                               SEQUENCE LISTING

<110> MODERNA THERAPEUTICS
 
<120> MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND 
      CYTOSKELETAL PROTEINS

<130> M306.20/2030.1306PCT

<140> PCT/US13/XXXXX
<141> 2013-03-09

<150> 61/737,213
<151> 2012-12-14

<150> 61/737,203
<151> 2012-12-14

<150> 61/737,191
<151> 2012-12-14

<150> 61/737,184
<151> 2012-12-14

<150> 61/737,174
<151> 2012-12-14

<150> 61/737,168
<151> 2012-12-14

<150> 61/737,160
<151> 2012-12-14

<150> 61/737,155
<151> 2012-12-14

<150> 61/737,152
<151> 2012-12-14

<150> 61/737,147
<151> 2012-12-14

<150> 61/737,139
<151> 2012-12-14

<150> 61/737,135
<151> 2012-12-14

<150> 61/737,134
<151> 2012-12-14

<150> 61/737,130
<151> 2012-12-14

<150> 61/712,490
<151> 2012-10-11

<150> 61/709,303
<151> 2012-10-03

<150> 61/696,381
<151> 2012-09-04

<150> 61/681,742
<151> 2012-08-10

<150> 61/681,720
<151> 2012-08-10

<150> 61/681,712
<151> 2012-08-10

<150> 61/681,704
<151> 2012-08-10

<150> 61/681,696
<151> 2012-08-10

<150> 61/681,687
<151> 2012-08-10

<150> 61/681,675
<151> 2012-08-10

<150> 61/681,667
<151> 2012-08-10

<150> 61/681,661
<151> 2012-08-10

<150> 61/681,658
<151> 2012-08-10

<150> 61/681,654
<151> 2012-08-10

<150> 61/681,650
<151> 2012-08-10

<150> 61/681,649
<151> 2012-08-10

<150> 61/681,648
<151> 2012-08-10

<150> 61/681,647
<151> 2012-08-10

<150> 61/681,645
<151> 2012-08-10

<150> 61/668,157
<151> 2012-07-05

<150> 61/648,286
<151> 2012-05-17

<150> 61/648,244
<151> 2012-05-17

<150> 61/618,961
<151> 2012-04-02

<150> 61/618,957
<151> 2012-04-02

<150> 61/618,953
<151> 2012-04-02

<150> 61/618,945
<151> 2012-04-02

<150> 61/618,935
<151> 2012-04-02

<150> 61/618,922
<151> 2012-04-02

<150> 61/618,911
<151> 2012-04-02

<150> 61/618,896
<151> 2012-04-02

<150> 61/618,885
<151> 2012-04-02

<150> 61/618,878
<151> 2012-04-02

<150> 61/618,873
<151> 2012-04-02

<150> 61/618,870
<151> 2012-04-02

<150> 61/618,868
<151> 2012-04-02

<150> 61/618,866
<151> 2012-04-02

<150> 61/618,862
<151> 2012-04-02

<160> 31925 

<170> PatentIn version 3.5

<210> 1
<211> 47
<212> DNA
<213> Homo sapiens

<400> 1
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210> 2
<211> 47
<212> DNA
<213> Homo sapiens

<400> 2
gggagatcag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210> 3
<211> 145
<212> DNA
<213> Homo sapiens

<400> 3
ggaataaaag tctcaacaca acatatacaa aacaaacgaa tctcaagcaa tcaagcattc       60

tacttctatt gcagcaattt aaatcatttc ttttaaagca aaagcaattt tctgaaaatt      120

ttcaccattt acgaacgata gcaac                                            145


<210> 4
<211> 42
<212> RNA
<213> Homo sapiens

<400> 4
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210> 5
<211> 371
<212> DNA
<213> Homo sapiens

<400> 5
gcgcctgccc acctgccacc gactgctgga acccagccag tgggagggcc tggcccacca       60

gagtcctgct ccctcactcc tcgccccgcc ccctgtccca gagtcccacc tgggggctct      120

ctccaccctt ctcagagttc cagtttcaac cagagttcca accaatgggc tccatcctct      180

ggattctggc caatgaaata tctccctggc agggtcctct tcttttccca gagctccacc      240

ccaaccagga gctctagtta atggagagct cccagcacac tcggagcttg tgctttgtct      300

ccacgcaaag cgataaataa aagcattggt ggcctttggt ctttgaataa agcctgagta      360

ggaagtctag a                                                           371


<210> 6
<211> 568
<212> DNA
<213> Homo sapiens

<400> 6
gcccctgccg ctcccacccc cacccatctg ggccccgggt tcaagagaga gcggggtctg       60

atctcgtgta gccatataga gtttgcttct gagtgtctgc tttgtttagt agaggtgggc      120

aggaggagct gaggggctgg ggctggggtg ttgaagttgg ctttgcatgc ccagcgatgc      180

gcctccctgt gggatgtcat caccctggga accgggagtg gcccttggct cactgtgttc      240

tgcatggttt ggatctgaat taattgtcct ttcttctaaa tcccaaccga acttcttcca      300

acctccaaac tggctgtaac cccaaatcca agccattaac tacacctgac agtagcaatt      360

gtctgattaa tcactggccc cttgaagaca gcagaatgtc cctttgcaat gaggaggaga      420

tctgggctgg gcgggccagc tggggaagca tttgactatc tggaacttgt gtgtgcctcc      480

tcaggtatgg cagtgactca cctggtttta ataaaacaac ctgcaacatc tcatggtctt      540

tgaataaagc ctgagtagga agtctaga                                         568


<210> 7
<211> 289
<212> DNA
<213> Homo sapiens

<400> 7
acacactcca cctccagcac gcgacttctc aggacgacga atcttctcaa tgggggggcg       60

gctgagctcc agccaccccg cagtcacttt ctttgtaaca acttccgttg ctgccatcgt      120

aaactgacac agtgtttata acgtgtacat acattaactt attacctcat tttgttattt      180

ttcgaaacaa agccctgtgg aagaaaatgg aaaacttgaa gaagcattaa agtcattctg      240

ttaagctgcg taaatggtct ttgaataaag cctgagtagg aagtctaga                  289


<210> 8
<211> 379
<212> DNA
<213> Homo sapiens

<400> 8
catcacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa tgaagatcaa       60

aagcttattc atctgttttt ctttttcgtt ggtgtaaagc caacaccctg tctaaaaaac      120

ataaatttct ttaatcattt tgcctctttt ctctgtgctt caattaataa aaaatggaaa      180

gaatctaata gagtggtaca gcactgttat ttttcaaaga tgtgttgcta tcctgaaaat      240

tctgtaggtt ctgtggaagt tccagtgttc tctcttattc cacttcggta gaggatttct      300

agtttcttgt gggctaatta aataaatcat taatactctt ctaatggtct ttgaataaag      360

cctgagtagg aagtctaga                                                   379


<210> 9
<211> 118
<212> DNA
<213> Mus sp.

<400> 9
gctgccttct gcggggcttg ccttctggcc atgcccttct tctctccctt gcacctgtac       60

ctcttggtct ttgaataaag cctgagtagg aaggcggccg ctcgagcatg catctaga        118


<210> 10
<211> 908
<212> DNA
<213> Homo sapiens

<400> 10
gccaagccct ccccatccca tgtatttatc tctatttaat atttatgtct atttaagcct       60

catatttaaa gacagggaag agcagaacgg agccccaggc ctctgtgtcc ttccctgcat      120

ttctgagttt cattctcctg cctgtagcag tgagaaaaag ctcctgtcct cccatcccct      180

ggactgggag gtagataggt aaataccaag tatttattac tatgactgct ccccagccct      240

ggctctgcaa tgggcactgg gatgagccgc tgtgagcccc tggtcctgag ggtccccacc      300

tgggaccctt gagagtatca ggtctcccac gtgggagaca agaaatccct gtttaatatt      360

taaacagcag tgttccccat ctgggtcctt gcacccctca ctctggcctc agccgactgc      420

acagcggccc ctgcatcccc ttggctgtga ggcccctgga caagcagagg tggccagagc      480

tgggaggcat ggccctgggg tcccacgaat ttgctgggga atctcgtttt tcttcttaag      540

acttttggga catggtttga ctcccgaaca tcaccgacgc gtctcctgtt tttctgggtg      600

gcctcgggac acctgccctg cccccacgag ggtcaggact gtgactcttt ttagggccag      660

gcaggtgcct ggacatttgc cttgctggac ggggactggg gatgtgggag ggagcagaca      720

ggaggaatca tgtcaggcct gtgtgtgaaa ggaagctcca ctgtcaccct ccacctcttc      780

accccccact caccagtgtc ccctccactg tcacattgta actgaacttc aggataataa      840

agtgtttgcc tccatggtct ttgaataaag cctgagtagg aaggcggccg ctcgagcatg      900

catctaga                                                               908


<210> 11
<211> 835
<212> DNA
<213> Homo sapiens

<400> 11
actcaatcta aattaaaaaa gaaagaaatt tgaaaaaact ttctctttgc catttcttct       60

tcttcttttt taactgaaag ctgaatcctt ccatttcttc tgcacatcta cttgcttaaa      120

ttgtgggcaa aagagaaaaa gaaggattga tcagagcatt gtgcaataca gtttcattaa      180

ctccttcccc cgctccccca aaaatttgaa tttttttttc aacactctta cacctgttat      240

ggaaaatgtc aacctttgta agaaaaccaa aataaaaatt gaaaaataaa aaccataaac      300

atttgcacca cttgtggctt ttgaatatct tccacagagg gaagtttaaa acccaaactt      360

ccaaaggttt aaactacctc aaaacacttt cccatgagtg tgatccacat tgttaggtgc      420

tgacctagac agagatgaac tgaggtcctt gttttgtttt gttcataata caaaggtgct      480

aattaatagt atttcagata cttgaagaat gttgatggtg ctagaagaat ttgagaagaa      540

atactcctgt attgagttgt atcgtgtggt gtatttttta aaaaatttga tttagcattc      600

atattttcca tcttattccc aattaaaagt atgcagatta tttgcccaaa tcttcttcag      660

attcagcatt tgttctttgc cagtctcatt ttcatcttct tccatggttc cacagaagct      720

ttgtttcttg ggcaagcaga aaaattaaat tgtacctatt ttgtatatgt gagatgttta      780

aataaattgt gaaaaaaatg aaataaagca tgtttggttt tccaaaagaa catat           835


<210> 12
<211> 297
<212> DNA
<213> Homo sapiens

<400> 12
cgccgccgcc cgggccccgc agtcgagggt cgtgagccca ccccgtccat ggtgctaagc       60

gggcccgggt cccacacggc cagcaccgct gctcactcgg acgacgccct gggcctgcac      120

ctctccagct cctcccacgg ggtccccgta gccccggccc ccgcccagcc ccaggtctcc      180

ccaggccctc cgcaggctgc ccggcctccc tccccctgca gccatcccaa ggctcctgac      240

ctacctggcc cctgagctct ggagcaagcc ctgacccaat aaaggctttg aacccat         297


<210> 13
<211> 602
<212> DNA
<213> Homo sapiens

<400> 13
ggggctagag ccctctccgc acagcgtgga gacggggcaa ggaggggggt tattaggatt       60

ggtggttttg ttttgctttg tttaaagccg tgggaaaatg gcacaacttt acctctgtgg      120

gagatgcaac actgagagcc aaggggtggg agttgggata atttttatat aaaagaagtt      180

tttccacttt gaattgctaa aagtggcatt tttcctatgt gcagtcactc ctctcatttc      240

taaaataggg acgtggccag gcacggtggc tcatgcctgt aatcccagca ctttgggagg      300

ccgaggcagg cggctcacga ggtcaggaga tcgagactat cctggctaac acggtaaaac      360

cctgtctcta ctaaaagtac aaaaaattag ctgggcgtgg tggtgggcac ctgtagtccc      420

agctactcgg gaggctgagg caggagaaag gcatgaatcc aagaggcaga gcttgcagtg      480

agctgagatc acgccattgc actccagcct gggcaacagt gttaagactc tgtctcaaat      540

ataaataaat aaataaataa ataaataaat aaataaaaat aaagcgagat gttgccctca      600

aa                                                                     602


<210> 14
<211> 785
<212> DNA
<213> Homo sapiens

<400> 14
ggccctgccc cgtcggactg cccccagaaa gcctcctgcc ccctgccagt gaagtccttc       60

agtgagcccc tccccagcca gcccttccct ggccccgccg gatgtataaa tgtaaaaatg      120

aaggaattac attttatatg tgagcgagca agccggcaag cgagcacagt attatttctc      180

catcccctcc ctgcctgctc cttggcaccc ccatgctgcc ttcagggaga caggcaggga      240

gggcttgggg ctgcacctcc taccctccca ccagaacgca ccccactggg agagctggtg      300

gtgcagcctt cccctccctg tataagacac tttgccaagg ctctcccctc tcgccccatc      360

cctgcttgcc cgctcccaca gcttcctgag ggctaattct gggaagggag agttctttgc      420

tgcccctgtc tggaagacgt ggctctgggt gaggtaggcg ggaaaggatg gagtgtttta      480

gttcttgggg gaggccaccc caaaccccag ccccaactcc aggggcacct atgagatggc      540

catgctcaac ccccctccca gacaggccct ccctgtctcc agggccccca ccgaggttcc      600

cagggctgga gacttcctct ggtaaacatt cctccagcct cccctcccct ggggacgcca      660

aggaggtggg ccacacccag gaagggaaag cgggcagccc cgttttgggg acgtgaacgt      720

tttaataatt tttgctgaat tcctttacaa ctaaataaca cagatattgt tataaataaa      780

attgt                                                                  785


<210> 15
<211> 3001
<212> DNA
<213> Homo sapiens

<400> 15
atattaagga tcaagctgtt agctaataat gccacctctg cagttttggg aacaggcaaa       60

taaagtatca gtatacatgg tgatgtacat ctgtagcaaa gctcttggag aaaatgaaga      120

ctgaagaaag caaagcaaaa actgtataga gagatttttc aaaagcagta atccctcaat      180

tttaaaaaag gattgaaaat tctaaatgtc tttctgtgca tattttttgt gttaggaatc      240

aaaagtattt tataaaagga gaaagaacag cctcatttta gatgtagtcc tgttggattt      300

tttatgcctc ctcagtaacc agaaatgttt taaaaaacta agtgtttagg atttcaagac      360

aacattatac atggctctga aatatctgac acaatgtaaa cattgcaggc acctgcattt      420

tatgtttttt ttttcaacaa atgtgactaa tttgaaactt ttatgaactt ctgagctgtc      480

cccttgcaat tcaaccgcag tttgaattaa tcatatcaaa tcagttttaa ttttttaaat      540

tgtacttcag agtctatatt tcaagggcac attttctcac tactatttta atacattaaa      600

ggactaaata atctttcaga gatgctggaa acaaatcatt tgctttatat gtttcattag      660

aataccaatg aaacatacaa cttgaaaatt agtaatagta tttttgaaga tcccatttct      720

aattggagat ctctttaatt tcgatcaact tataatgtgt agtactatat taagtgcact      780

tgagtggaat tcaacatttg actaataaaa tgagttcatc atgttggcaa gtgatgtggc      840

aattatctct ggtgacaaaa gagtaaaatc aaatatttct gcctgttaca aatatcaagg      900

aagacctgct actatgaaat agatgacatt aatctgtctt cactgtttat aatacggatg      960

gatttttttt caaatcagtg tgtgttttga ggtcttatgt aattgatgac atttgagaga     1020

aatggtggct ttttttagct acctctttgt tcatttaagc accagtaaag atcatgtctt     1080

tttatagaag tgtagatttt ctttgtgact ttgctatcgt gcctaaagct ctaaatatag     1140

gtgaatgtgt gatgaatact cagattattt gtctctctat ataattagtt tggtactaag     1200

tttctcaaaa aattattaac acatgaaaga caatctctaa accagaaaaa gaagtagtac     1260

aaattttgtt actgtaatgc tcgcgtttag tgagtttaaa acacacagta tcttttggtt     1320

ttataatcag tttctatttt gctgtgcctg agattaagat ctgtgtatgt gtgtgtgtgt     1380

gtgtgtgcgt ttgtgtgtta aagcagaaaa gactttttta aaagttttaa gtgataaatg     1440

caatttgtta attgatctta gatcactagt aaactcaggg ctgaattata ccatgtatat     1500

tctattagaa gaaagtaaac accatcttta ttcctgccct ttttcttctc tcaaagtagt     1560

tgtagttata tctagaaaga agcaattttg atttcttgaa aaggtagttc ctgcactcag     1620

tttaaactaa aaataatcat acttggattt tatttatttt tgtcatagta aaaattttaa     1680

tttatatata tttttattta gtattatctt attctttgct atttgccaat cctttgtcat     1740

caattgtgtt aaatgaattg aaaattcatg ccctgttcat tttattttac tttattggtt     1800

aggatattta aaggattttt gtatatataa tttcttaaat taatattcca aaaggttagt     1860

ggacttagat tataaattat ggcaaaaatc taaaaacaac aaaaatgatt tttatacatt     1920

ctatttcatt attcctcttt ttccaataag tcatacaatt ggtagatatg acttatttta     1980

tttttgtatt attcactata tctttatgat atttaagtat aaataattaa aaaaatttat     2040

tgtaccttat agtctgtcac caaaaaaaaa aaattatctg taggtagtga aatgctaatg     2100

ttgatttgtc tttaagggct tgttaactat cctttatttt ctcatttgtc ttaaattagg     2160

agtttgtgtt taaattactc atctaagcaa aaaatgtata taaatcccat tactgggtat     2220

atacccaaag gattataaat catgctgcta taaagacaca tgcacacgta tgtttattgc     2280

agcactattc acaatagcaa agacttggaa ccaacccaaa tgtccatcaa tgatagactt     2340

gattaagaaa atgtgcacat atacaccatg gaatactatg cagccataaa aaaggatgag     2400

ttcatgtcct ttgtagggac atggataaag ctggaaacca tcattctgag caaactattg     2460

caaggacaga aaaccaaaca ctgcatgttc tcactcatag gtgggaattg aacaatgaga     2520

acacttggac acaaggtggg gaacaccaca caccagggcc tgtcatgggg tggggggagt     2580

ggggagggat agcattagga gatataccta atgtaaatga tgagttaatg ggtgcagcac     2640

accaacatgg cacatgtata catatgtagc aaacctgcac gttgtgcaca tgtaccctag     2700

aacttaaagt ataattaaaa aaaaaaagaa aacagaagct atttataaag aagttatttg     2760

ctgaaataaa tgtgatcttt cccattaaaa aaataaagaa attttggggt aaaaaaacac     2820

aatatattgt attcttgaaa aattctaaga gagtggatgt gaagtgttct caccacaaaa     2880

gtgataacta attgaggtaa tgcacatatt aattagaaag attttgtcat tccacaatgt     2940

atatatactt aaaaatatgt tatacacaat aaatacatac attaaaaaat aagtaaatgt     3000

a                                                                     3001


<210> 16
<211> 1037
<212> DNA
<213> Homo sapiens

<400> 16
cccaccctgc acgccggcac caaaccctgt cctcccaccc ctccccactc atcactaaac       60

agagtaaaat gtgatgcgaa ttttcccgac caacctgatt cgctagattt tttttaagga      120

aaagcttgga aagccaggac acaacgctgc tgcctgcttt gtgcagggtc ctccggggct      180

cagccctgag ttggcatcac ctgcgcaggg ccctctgggg ctcagccctg agctagtgtc      240

acctgcacag ggccctctga ggctcagccc tgagctggcg tcacctgtgc agggccctct      300

ggggctcagc cctgagctgg cctcacctgg gttccccacc ccgggctctc ctgccctgcc      360

ctcctgcccg ccctccctcc tgcctgcgca gctccttccc taggcacctc tgtgctgcat      420

cccaccagcc tgagcaagac gccctctcgg ggcctgtgcc gcactagcct ccctctcctc      480

tgtccccata gctggttttt cccaccaatc ctcacctaac agttacttta caattaaact      540

caaagcaagc tcttctcctc agcttggggc agccattggc ctctgtctcg ttttgggaaa      600

ccaaggtcag gaggccgttg cagacataaa tctcggcgac tcggccccgt ctcctgaggg      660

tcctgctggt gaccggcctg gaccttggcc ctacagccct ggaggccgct gctgaccagc      720

actgaccccg acctcagaga gtactcgcag gggcgctggc tgcactcaag accctcgaga      780

ttaacggtgc taaccccgtc tgctcctccc tcccgcagag actggggcct ggactggaca      840

tgagagcccc ttggtgccac agagggctgt gtcttactag aaacaacgca aacctctcct      900

tcctcagaat agtgatgtgt tcgacgtttt atcaaaggcc ccctttctat gttcatgtta      960

gttttgctcc ttctgtgttt ttttctgaac catatccatg ttgctgactt ttccaaataa     1020

aggttttcac tcctctc                                                    1037


<210> 17
<211> 577
<212> DNA
<213> Homo sapiens

<400> 17
agaggcctgc ctccagggct ggactgaggc ctgagcgctc ctgccgcaga gctggccgcg       60

ccaaataatg tctctgtgag actcgagaac tttcattttt ttccaggctg gttcggattt      120

ggggtggatt ttggttttgt tcccctcctc cactctcccc caccccctcc ccgccctttt      180

tttttttttt ttttaaactg gtattttatc tttgattctc cttcagccct cacccctggt      240

tctcatcttt cttgatcaac atcttttctt gcctctgtcc ccttctctca tctcttagct      300

cccctccaac ctggggggca gtggtgtgga gaagccacag gcctgagatt tcatctgctc      360

tccttcctgg agcccagagg agggcagcag aagggggtgg tgtctccaac cccccagcac      420

tgaggaagaa cggggctctt ctcatttcac ccctcccttt ctcccctgcc cccaggactg      480

ggccacttct gggtggggca gtgggtccca gattggctca cactgagaat gtaagaacta      540

caaacaaaat ttctattaaa ttaaattttg tgtctcc                               577


<210> 18
<211> 2212
<212> DNA
<213> Homo sapiens

<400> 18
ctccctccat cccaacctgg ctccctccca cccaaccaac tttcccccca acccggaaac       60

agacaagcaa cccaaactga accccctcaa aagccaaaaa atgggagaca atttcacatg      120

gactttggaa aatatttttt tcctttgcat tcatctctca aacttagttt ttatctttga      180

ccaaccgaac atgaccaaaa accaaaagtg cattcaacct taccaaaaaa aaaaaaaaaa      240

aaagaataaa taaataactt tttaaaaaag gaagcttggt ccacttgctt gaagacccat      300

gcgggggtaa gtccctttct gcccgttggg cttatgaaac cccaatgctg ccctttctgc      360

tcctttctcc acacccccct tggggcctcc cctccactcc ttcccaaatc tgtctcccca      420

gaagacacag gaaacaatgt attgtctgcc cagcaatcaa aggcaatgct caaacaccca      480

agtggccccc accctcagcc cgctcctgcc cgcccagcac ccccaggccc tgggggacct      540

ggggttctca gactgccaaa gaagccttgc catctggcgc tcccatggct cttgcaacat      600

ctccccttcg tttttgaggg ggtcatgccg ggggagccac cagcccctca ctgggttcgg      660

aggagagtca ggaagggcca cgacaaagca gaaacatcgg atttggggaa cgcgtgtcaa      720

tcccttgtgc cgcagggctg ggcgggagag actgttctgt tccttgtgta actgtgttgc      780

tgaaagacta cctcgttctt gtcttgatgt gtcaccgggg caactgcctg ggggcgggga      840

tgggggcagg gtggaagcgg ctccccattt tataccaaag gtgctacatc tatgtgatgg      900

gtggggtggg gagggaatca ctggtgctat agaaattgag atgccccccc aggccagcaa      960

atgttccttt ttgttcaaag tctattttta ttccttgata tttttctttt tttttttttt     1020

tttttgtgga tggggacttg tgaatttttc taaaggtgct atttaacatg ggaggagagc     1080

gtgtgcggct ccagcccagc ccgctgctca ctttccaccc tctctccacc tgcctctggc     1140

ttctcaggcc tctgctctcc gacctctctc ctctgaaacc ctcctccaca gctgcagccc     1200

atcctcccgg ctccctccta gtctgtcctg cgtcctctgt ccccgggttt cagagacaac     1260

ttcccaaagc acaaagcagt ttttccccct aggggtggga ggaagcaaaa gactctgtac     1320

ctattttgta tgtgtataat aatttgagat gtttttaatt attttgattg ctggaataaa     1380

gcatgtggaa atgacccaaa cataatccgc agtggcctcc taatttcctt ctttggagtt     1440

gggggagggg tagacatggg gaaggggctt tggggtgatg ggcttgcctt ccattcctgc     1500

cctttccctc cccactattc tcttctagat ccctccataa ccccactccc ctttctctca     1560

cccttcttat accgcaaacc tttctacttc ctctttcatt ttctattctt gcaatttcct     1620

tgcacctttt ccaaatcctc ttctcccctg caataccata caggcaatcc acgtgcacaa     1680

cacacacaca cactcttcac atctggggtt gtccaaacct catacccact ccccttcaag     1740

cccatccact ctccaccccc tggatgccct gcacttggtg gcggtgggat gctcatggat     1800

actgggaggg tgaggggagt ggaacccgtg aggaggacct gggggcctct ccttgaactg     1860

acatgaaggg tcatctggcc tctgctccct tctcacccac gctgacctcc tgccgaagga     1920

gcaacgcaac aggagagggg tctgctgagc ctggcgaggg tctgggaggg accaggagga     1980

aggcgtgctc cctgctcgct gtcctggccc tgggggagtg agggagacag acacctggga     2040

gagctgtggg gaaggcactc gcaccgtgct cttgggaagg aaggagacct ggccctgctc     2100

accacggact gggtgcctcg acctcctgaa tccccagaac acaacccccc tgggctgggg     2160

tggtctgggg aaccatcgtg cccccgcctc ccgcctactc ctttttaagc tt             2212


<210> 19
<211> 729
<212> DNA
<213> Homo sapiens

<400> 19
ttggccaggc ctgaccctct tggacctttc ttctttgccg acaaccactg cccagcagcc       60

tctgggacct cggggtccca gggaacccag tccagcctcc tggctgttga cttcccattg      120

ctcttggagc caccaatcaa agagattcaa agagattcct gcaggccaga ggcggaacac      180

acctttatgg ctggggctct ccgtggtgtt ctggacccag cccctggaga caccattcac      240

ttttactgct ttgtagtgac tcgtgctctc caacctgtct tcctgaaaaa ccaaggcccc      300

cttcccccac ctcttccatg gggtgagact tgagcagaac aggggcttcc ccaagttgcc      360

cagaaagact gtctgggtga gaagccatgg ccagagcttc tcccaggcac aggtgttgca      420

ccagggactt ctgcttcaag ttttggggta aagacacctg gatcagactc caagggctgc      480

cctgagtctg ggacttctgc ctccatggct ggtcatgaga gcaaaccgta gtcccctgga      540

gacagcgact ccagagaacc tcttgggaga cagaagaggc atctgtgcac agctcgatct      600

tctacttgcc tgtggggagg ggagtgacag gtccacacac cacactgggt caccctgtcc      660

tggatgcctc tgaagagagg gacagaccgt cagaaactgg agagtttcta ttaaaggtca      720

tttaaacca                                                              729


<210> 20
<211> 847
<212> DNA
<213> Homo sapiens

<400> 20
tcctccggga ccccagccct caggattcct gatgctccaa ggcgactgat gggcgctgga       60

tgaagtggca cagtcagctt ccctgggggc tggtgtcatg ttgggctcct ggggcggggg      120

cacggcctgg catttcacgc attgctgcca ccccaggtcc acctgtctcc actttcacag      180

cctccaagtc tgtggctctt cccttctgtc ctccgagggg cttgccttct ctcgtgtcca      240

gtgaggtgct cagtgatcgg cttaacttag agaagcccgc cccctcccct tctccgtctg      300

tcccaagagg gtctgctctg agcctgcgtt cctaggtggc tcggcctcag ctgcctgggt      360

tgtggccgcc ctagcatcct gtatgcccac agctactgga atccccgctg ctgctccggg      420

ccaagcttct ggttgattaa tgagggcatg gggtggtccc tcaagacctt cccctacctt      480

ttgtggaacc agtgatgcct caaagacagt gtcccctcca cagctgggtg ccaggggcag      540

gggatcctca gtatagccgg tgaaccctga taccaggagc ctgggcctcc ctgaacccct      600

ggcttccagc catctcatcg ccagcctcct cctggacctc ttggccccca gccccttccc      660

cacacagccc cagaagggtc ccagagctga ccccactcca ggacctaggc ccagcccctc      720

agcctcatct ggagcccctg aagaccagtc ccacccacct ttctggcctc atctgacact      780

gctccgcatc ctgctgtgtg tcctgttcca tgttccggtt ccatccaaat acactttctg      840

gaacaaa                                                                847


<210> 21
<211> 110
<212> DNA
<213> Homo sapiens

<400> 21
gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc       60

ttcctgcacc cgtacccccg tggtctttga ataaagtctg agtgggcggc                 110


<210> 22
<211> 27
<212> DNA
<213> Homo sapiens

<400> 22
ttggaccctc gtacagaagc taatacg                                           27


<210> 23
<211> 189
<212> DNA
<213> Homo sapiens

<400> 23
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      120

tttttttttt tttttttttt tttttttttt tttttttttt cttcctactc aggctttatt      180

caaagacca                                                              189


<210> 24
<211> 20
<212> DNA
<213> Homo sapiens

<400> 24
ccttgacctt ctggaacttc                                                   20


<210> 25
<211> 20
<212> DNA
<213> Homo sapiens

<400> 25
ccaagcactg aaacggatat                                                   20


<210> 26
<211> 20
<212> DNA
<213> Homo sapiens

<400> 26
gatgaaaagt gctccaagga                                                   20


<210> 27
<211> 20
<212> DNA
<213> Homo sapiens

<400> 27
aaccgtgatg aaaaggtacc                                                   20


<210> 28
<211> 20
<212> DNA
<213> Homo sapiens

<400> 28
tcatgcagat tggaaaggtc                                                   20


<210> 29
<211> 20
<212> DNA
<213> Homo sapiens

<400> 29
cttcttggac tgtccagagg                                                   20


<210> 30
<211> 20
<212> DNA
<213> Homo sapiens

<400> 30
gcagtccctg atacaagaac                                                   20


<210> 31
<211> 20
<212> DNA
<213> Homo sapiens

<400> 31
gattgaaggt ggctcgctac                                                   20


<210> 32
<211> 75
<212> DNA
<213> Homo sapiens

<400> 32
atgatgccat cctcagtctc atggggtatt ttgctcttgg cgggtctgtg ctgtctcgtg       60

ccggtgtcgc tcgca                                                        75


<210> 33
<211> 90
<212> DNA
<213> Homo sapiens

<400> 33
atggccggac cggcgactca gtcgcccatg aaactcatgg ccctgcagtt gttgctttgg       60

cactcagccc tctggaccgt ccaagaggcg                                        90


<210> 34
<211> 137
<212> DNA
<213> Homo sapiens

<400> 34
atgcagagag tgaacatgat tatggccgag tccccatcgc tcatcacaat ctgcctgctt       60

ggtacctgct ttccgccgaa tgcactgtct ttctggatca cgagaatgcg aataagatct      120

tgaaccgacc caaacgg                                                     137


<210> 35
<211> 63
<212> DNA
<213> Homo sapiens

<400> 35
atgaaaggat cattgctgtt gctcctcgtg tcgaaccttc tgctttgcca gtccgtagcc       60

ccc                                                                     63


<210> 36
<211> 72
<212> DNA
<213> Homo sapiens

<400> 36
atgaaatggg tgacgttcat ctcactgttg tttttgttct cgtccgccta ctccagggga       60

gtattccgcc ga                                                           72


<210> 37
<211> 63
<212> DNA
<213> Homo sapiens

<400> 37
atgtggtggc ggctctggtg gctgctcctg ttgctcctct tgctgtggcc catggtgtgg       60

gca                                                                     63


<210> 38
<211> 95
<212> DNA
<213> Homo sapiens

<400> 38
tgctctttaa cctccgcatc ctgttgaata acgctgcgtt ccgaaatggg cataacttca       60

tggtacgcaa cttcagatgc ggccagccac tccag                                  95


<210> 39
<211> 87
<212> DNA
<213> Homo sapiens

<400> 39
atgtccgtct tgacacccct gctcttgaga gggctgacgg ggtccgctag acgcctgccg       60

gtaccgcgag cgaagatcca ctccctg                                           87


<210> 40
<211> 87
<212> DNA
<213> Homo sapiens

<400> 40
atgagcgtgc tcactccgtt gcttcttcga gggcttacgg gatcggctcg gaggttgccc       60

gtcccgagag cgaagatcca ttcgttg                                           87


<210> 41
<211> 175
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 41
tgacaaaaat aactttatct ccccagaatt ttagaatcca aaaacaggaa accacactac       60

taaaagaaaa atcaaccgag aaaaattctt tagcaaaaag tattctcgca gtaaaaatca      120

cttcatcgaa ttaaggtcaa aattatcgga acgttttatt tcgcataaga acact           175


<210> 42
<211> 69
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 42
atgctgagct ttgtggatac ccgcaccctg ctgctgctgg cggtgaccag ctgcctggcg       60

acctgccag                                                               69


<210> 43
<211> 96
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 43
atgggcagca gccaggcgcc gcgcatgggc agcgtgggcg gccatggcct gatggcgctg       60

ctgatggcgg gcctgattct gccgggcatt ctggcg                                 96


<210> 44
<211> 51
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 44
atggcgggca ttttttattt tctgtttagc tttctgtttg gcatttgcga t                51


<210> 45
<211> 66
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 45
atggaaaacc gcctgctgcg cgtgtttctg gtgtgggcgg cgctgaccat ggatggcgcg       60

agcgcg                                                                  66


<210> 46
<211> 81
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 46
atggcgcgcc agggctgctt tggcagctat caggtgatta gcctgtttac ctttgcgatt       60

ggcgtgaacc tgtgcctggg c                                                 81


<210> 47
<211> 57
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 47
atgagccgcc tgccggtgct gctgctgctg cagctgctgg tgcgcccggg cctgcag          57


<210> 48
<211> 87
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 48
atgaaacagc agaaacgcct gtatgcgcgc ctgctgaccc tgctgtttgc gctgattttt       60

ctgctgccgc atagcagcgc gagcgcg                                           87


<210> 49
<211> 78
<212> DNA
<213> Homo sapiens

<400> 49
atggcgacgc cgctgcctcc gccctccccg cggcacctgc ggctgctgcg gctgctgctc       60

tccgccctcg tcctcggc                                                     78


<210> 50
<211> 54
<212> DNA
<213> Homo sapiens

<400> 50
atgaaggctc cgggtcggct cgtgctcatc atcctgtgct ccgtggtctt ctct             54


<210> 51
<211> 45
<212> DNA
<213> Homo sapiens

<400> 51
atgcttcagc tttggaaact tgttctcctg tgcggcgtgc tcact                       45


<210> 52
<211> 39
<212> DNA
<213> Homo sapiens

<400> 52
atgctttatc tccagggttg gagcatgcct gctgtggca                              39


<210> 53
<211> 144
<212> DNA
<213> Homo sapiens

<400> 53
atggataacg tgcagccgaa aataaaacat cgccccttct gcttcagtgt gaaaggccac       60

gtgaagatgc tgcggctgga tattatcaac tcactggtaa caacagtatt catgctcatc      120

gtatctgtgt tggcactgat acca                                             144


<210> 54
<211> 96
<212> DNA
<213> Homo sapiens

<400> 54
atgccctgcc tagaccaaca gctcactgtt catgccctac cctgccctgc ccagccctcc       60

tctctggcct tctgccaagt ggggttctta acagca                                 96


<210> 55
<211> 138
<212> DNA
<213> Homo sapiens

<400> 55
atgaaaacct tgttcaatcc agcccctgcc attgctgacc tggatcccca gttctacacc       60

ctctcagatg tgttctgctg caatgaaagt gaggctgaga ttttaactgg cctcacggtg      120

ggcagcgctg cagatgct                                                    138


<210> 56
<211> 57
<212> DNA
<213> Homo sapiens

<400> 56
atgaagcctc tccttgttgt gtttgtcttt cttttccttt gggatccagt gctggca          57


<210> 57
<211> 63
<212> DNA
<213> Homo sapiens

<400> 57
atgtcctgtt ccctaaagtt tactttgatt gtaatttttt tttactgttg gctttcatcc       60

agc                                                                     63


<210> 58
<211> 210
<212> DNA
<213> Homo sapiens

<400> 58
atggttctta ctaaacctct tcaaagaaat ggcagcatga tgagctttga aaatgtgaaa       60

gaaaagagca gagaaggagg gccccatgca cacacacccg aagaagaatt gtgtttcgtg      120

gtaacacact accctcaggt tcagaccaca ctcaacctgt ttttccatat attcaaggtt      180

cttactcaac cactttccct tctgtggggt                                       210


<210> 59
<211> 96
<212> DNA
<213> Homo sapiens

<400> 59
atggccaccc cgccattccg gctgataagg aagatgtttt ccttcaaggt gagcagatgg       60

atggggcttg cctgcttccg gtccctggcg gcatcc                                 96


<210> 60
<211> 87
<212> DNA
<213> Homo sapiens

<400> 60
atgagctttt tccaactcct gatgaaaagg aaggaactca ttcccttggt ggtgttcatg       60

actgtggcgg cgggtggagc ctcatct                                           87


<210> 61
<211> 123
<212> DNA
<213> Homo sapiens

<400> 61
atggtctcag ctctgcgggg agcacccctg atcagggtgc actcaagccc tgtttcttct       60

ccttctgtga gtggaccacg gaggctggtg agctgcctgt catcccaaag ctcagctctg      120

agc                                                                    123


<210> 62
<211> 60
<212> DNA
<213> Homo sapiens

<400> 62
atgatggggt ccccagtgag tcatctgctg gccggcttct gtgtgtgggt cgtcttgggc       60


<210> 63
<211> 69
<212> DNA
<213> Homo sapiens

<400> 63
atggcaagca tggctgccgt gctcacctgg gctctggctc ttctttcagc gttttcggcc       60

acccaggca                                                               69


<210> 64
<211> 135
<212> DNA
<213> Homo sapiens

<400> 64
atggtgctca tgtggaccag tggtgacgcc ttcaagacgg cctacttcct gctgaagggt       60

gcccctctgc agttctccgt gtgcggcctg ctgcaggtgc tggtggacct ggccatcctg      120

gggcaggcct acgcc                                                       135


<210> 65
<211> 204
<212> DNA
<213> Homo sapiens

<400> 65
atggattttg tcgctggagc catcggaggc gtctgcggtg ttgctgtggg ctaccccctg       60

gacacggtga aggtcaggat ccagacggag ccaaagtaca caggcatctg gcactgcgtc      120

cgggatacgt atcaccgaga gcgcgtgtgg ggcttctacc ggggcctctc gctgcccgtg      180

tgcacggtgt ccctggtatc ttcc                                             204


<210> 66
<211> 147
<212> DNA
<213> Homo sapiens

<400> 66
atggagaagc ccctcttccc attagtgcct ttgcattggt ttggctttgg ctacacagca       60

ctggttgttt ctggtgggat cgttggctat gtaaaaacag gcagcgtgcc gtccctggct      120

gcagggctgc tcttcggcag tctagcc                                          147


<210> 67
<211> 45
<212> DNA
<213> Homo sapiens

<400> 67
atgggtctgc tccttcccct ggcactctgc atcctagtcc tgtgc                       45


<210> 68
<211> 78
<212> DNA
<213> Homo sapiens

<400> 68
atggggatcc agacgagccc cgtcctgctg gcctccctgg gggtggggct ggtcactctg       60

ctcggcctgg ctgtgggc                                                     78


<210> 69
<211> 75
<212> DNA
<213> Homo sapiens

<400> 69
atgtcggacc tgctactact gggcctgatt gggggcctga ctctcttact gctgctgacg       60

ctgctagcct ttgcc                                                        75


<210> 70
<211> 87
<212> DNA
<213> Homo sapiens

<400> 70
atggagactg tggtgattgt tgccataggt gtgctggcca ccatgtttct ggcttcgttt       60

gcagccttgg tgctggtttg caggcag                                           87


<210> 71
<211> 105
<212> DNA
<213> Homo sapiens

<400> 71
atgcgcggct ctgtggagtg cacctggggt tgggggcact gtgcccccag ccccctgctc       60

ctttggactc tacttctgtt tgcagcccca tttggcctgc tgggg                      105


<210> 72
<211> 171
<212> DNA
<213> Homo sapiens

<400> 72
atgatgccgt cccgtaccaa cctggctact ggaatcccca gtagtaaagt gaaatattca       60

aggctctcca gcacagacga tggctacatt gaccttcagt ttaagaaaac ccctcctaag      120

atcccttata aggccatcgc acttgccact gtgctgtttt tgattggcgc c               171


<210> 73
<211> 108
<212> DNA
<213> Homo sapiens

<400> 73
atggccctgc cccagatgtg tgacgggagc cacttggcct ccaccctccg ctattgcatg       60

acagtcagcg gcacagtggt tctggtggcc gggacgctct gcttcgct                   108


<210> 74
<211> 63
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 74
tgaaaaagtg gttcgttgct gccggcatcg gcgctgccgg actcatgctc tccagcgccg       60

cca                                                                     63


<210> 75
<211> 63
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 75
atgaaacaga gcaccattgc gctggcgctg ctgccgctgc tgtttacccc ggtgaccaaa       60

gcg                                                                     63


<210> 76
<211> 63
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 76
atgaaaaaaa ccgcgattgc gattgcggtg gcgctggcgg gctttgcgac cgtggcgcag       60

gcg                                                                     63


<210> 77
<211> 63
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 77
atgaaaaaac tgatgctggc gatttttttt agcgtgctga gctttccgag ctttagccag       60

agc                                                                     63


<210> 78
<211> 69
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 78
atgaaaaaaa acattgcgtt tctgctggcg agcatgtttg tgtttagcat tgcgaccaac       60

gcgtatgcg                                                               69


<210> 79
<211> 96
<212> DNA
<213> Homo sapiens

<400> 79
atgtttgcga aacgctttaa aaccagcctg ctgccgctgt ttgcgggctt tctgctgctg       60

tttcatctgg tgctggcggg cccggcggcg gcgagc                                 96


<210> 80
<211> 57
<212> DNA
<213> Homo sapiens

<400> 80
atgcgctttc cgagcatttt taccgcggtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 81
<211> 57
<212> DNA
<213> Homo sapiens

<400> 81
atgcgctttc cgagcatttt taccaccgtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 82
<211> 57
<212> DNA
<213> Homo sapiens

<400> 82
atgcgctttc cgagcatttt taccagcgtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 83
<211> 57
<212> DNA
<213> Homo sapiens

<400> 83
atgcgctttc cgagcatttt tacccatgtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 84
<211> 57
<212> DNA
<213> Homo sapiens

<400> 84
atgcgctttc cgagcatttt taccattgtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 85
<211> 57
<212> DNA
<213> Homo sapiens

<400> 85
atgcgctttc cgagcatttt tacctttgtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 86
<211> 57
<212> DNA
<213> Homo sapiens

<400> 86
atgcgctttc cgagcatttt taccgaagtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 87
<211> 57
<212> DNA
<213> Homo sapiens

<400> 87
atgcgctttc cgagcatttt taccggcgtg ctgtttgcgg cgagcagcgc gctggcg          57


<210> 88
<211> 63
<212> DNA
<213> Homo sapiens

<400> 88
atgcgttcct cccccctcct ccgctccgcc gttgtggccg ccctgccggt gttggccctt       60

gcc                                                                     63


<210> 89
<211> 66
<212> DNA
<213> Homo sapiens

<400> 89
atgggcgcgg cggccgtgcg ctggcacttg tgcgtgctgc tggccctggg cacacgcggg       60

cggctg                                                                  66


<210> 90
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 90
atgaggagct cccttgtgct gttctttgtc tctgcgtgga cggccttggc cag              53


<210> 91
<211> 96
<212> DNA
<213> Homo sapiens

<400> 91
atgctcaggg gtccgggacc cgggcggctg ctgctgctag cagtcctgtg cctggggaca       60

tcggtgcgct gcaccgaaac cgggaagagc aagagg                                 96


<210> 92
<211> 69
<212> DNA
<213> Homo sapiens

<400> 92
atgcttaggg gtccggggcc cgggctgctg ctgctggccg tccagctggg gacagcggtg       60

ccctccacg                                                               69


<210> 93
<211> 93
<212> DNA
<213> Homo sapiens

<400> 93
atgcgccggg gggccctgac cgggctgctc ctggtcctgt gcctgagtgt tgtgctacgt       60

gcagccccct ctgcaacaag caagaagcgc agg                                    93


<210> 94
<211> 24
<212> PRT
<213> Homo sapiens

<400> 94
Met Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210> 95
<211> 30
<212> PRT
<213> Homo sapiens

<400> 95
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala 
            20                  25                  30  


<210> 96
<211> 46
<212> PRT
<213> Homo sapiens

<400> 96
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Ser Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg 
        35                  40                  45      


<210> 97
<211> 21
<212> PRT
<213> Homo sapiens

<400> 97
Met Lys Gly Ser Leu Leu Leu Leu Leu Val Ser Asn Leu Leu Leu Cys 
1               5                   10                  15      


Gln Ser Val Ala Pro 
            20      


<210> 98
<211> 24
<212> PRT
<213> Homo sapiens

<400> 98
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg 
            20                  


<210> 99
<211> 19
<212> PRT
<213> Homo sapiens

<400> 99
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Trp Ala 
            


<210> 100
<211> 32
<212> PRT
<213> Homo sapiens

<400> 100
Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln 
            20                  25                  30          


<210> 101
<211> 29
<212> PRT
<213> Homo sapiens

<400> 101
Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu 
            20                  25                  


<210> 102
<211> 29
<212> PRT
<213> Homo sapiens

<400> 102
Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu 
            20                  25                  


<210> 103
<211> 59
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 103
Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr 
    50                  55                  


<210> 104
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 104
Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Ser Cys Leu Ala Thr Cys Gln 
            20              


<210> 105
<211> 32
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 105
Met Gly Ser Ser Gln Ala Pro Arg Met Gly Ser Val Gly Gly His Gly 
1               5                   10                  15      


Leu Met Ala Leu Leu Met Ala Gly Leu Ile Leu Pro Gly Ile Leu Ala 
            20                  25                  30          


<210> 106
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 106
Met Ala Gly Ile Phe Tyr Phe Leu Phe Ser Phe Leu Phe Gly Ile Cys 
1               5                   10                  15      


Asp 
    


<210> 107
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 107
Met Glu Asn Arg Leu Leu Arg Val Phe Leu Val Trp Ala Ala Leu Thr 
1               5                   10                  15      


Met Asp Gly Ala Ser Ala 
            20          


<210> 108
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Viral signal sequence

<400> 108
Met Ala Arg Gln Gly Cys Phe Gly Ser Tyr Gln Val Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Ile Gly Val Asn Leu Cys Leu Gly 
            20                  25          


<210> 109
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 109
Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln 
            


<210> 110
<211> 29
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 110
Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe 
1               5                   10                  15      


Ala Leu Ile Phe Leu Leu Pro His Ser Ser Ala Ser Ala 
            20                  25                  


<210> 111
<211> 22
<212> PRT
<213> Homo sapiens

<400> 111
Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg His Leu Arg Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Ser Gly 
            20          


<210> 112
<211> 18
<212> PRT
<213> Homo sapiens

<400> 112
Met Lys Ala Pro Gly Arg Leu Val Leu Ile Ile Leu Cys Ser Val Val 
1               5                   10                  15      


Phe Ser 
        


<210> 113
<211> 13
<212> PRT
<213> Homo sapiens

<400> 113
Met Leu Gln Leu Trp Lys Leu Leu Cys Gly Val Leu Thr 
1               5                   10              


<210> 114
<211> 13
<212> PRT
<213> Homo sapiens

<400> 114
Met Leu Tyr Leu Gln Gly Trp Ser Met Pro Ala Val Ala 
1               5                   10              


<210> 115
<211> 48
<212> PRT
<213> Homo sapiens

<400> 115
Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Asp Ile Ile Asn Ser Leu 
            20                  25                  30          


Val Thr Thr Val Phe Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro 
        35                  40                  45              


<210> 116
<211> 32
<212> PRT
<213> Homo sapiens

<400> 116
Met Pro Cys Leu Asp Gln Gln Leu Thr Val His Ala Leu Pro Cys Pro 
1               5                   10                  15      


Ala Gln Pro Ser Ser Leu Ala Phe Cys Gln Val Gly Phe Leu Thr Ala 
            20                  25                  30          


<210> 117
<211> 46
<212> PRT
<213> Homo sapiens

<400> 117
Met Lys Thr Leu Phe Asn Pro Ala Pro Ala Ile Ala Asp Leu Asp Pro 
1               5                   10                  15      


Gln Phe Tyr Thr Leu Ser Asp Val Phe Cys Cys Asn Glu Ser Glu Ala 
            20                  25                  30          


Glu Ile Leu Thr Gly Leu Thr Val Gly Ser Ala Ala Asp Ala 
        35                  40                  45      


<210> 118
<211> 19
<212> PRT
<213> Homo sapiens

<400> 118
Met Lys Pro Leu Leu Val Val Phe Val Phe Leu Phe Leu Trp Asp Pro 
1               5                   10                  15      


Val Leu Ala 
            


<210> 119
<211> 21
<212> PRT
<213> Homo sapiens

<400> 119
Met Ser Cys Ser Leu Lys Phe Thr Leu Ile Val Ile Phe Phe Thr Cys 
1               5                   10                  15      


Thr Leu Ser Ser Ser 
            20      


<210> 120
<211> 70
<212> PRT
<213> Homo sapiens

<400> 120
Met Val Leu Thr Lys Pro Leu Gln Arg Asn Gly Ser Met Met Ser Phe 
1               5                   10                  15      


Glu Asn Val Lys Glu Lys Ser Arg Glu Gly Gly Pro His Ala His Thr 
            20                  25                  30          


Pro Glu Glu Glu Leu Cys Phe Val Val Thr His Thr Pro Gln Val Gln 
        35                  40                  45              


Thr Thr Leu Asn Leu Phe Phe His Ile Phe Lys Val Leu Thr Gln Pro 
    50                  55                  60                  


Leu Ser Leu Leu Trp Gly 
65                  70  


<210> 121
<211> 32
<212> PRT
<213> Homo sapiens

<400> 121
Met Ala Thr Pro Pro Phe Arg Leu Ile Arg Lys Met Phe Ser Phe Lys 
1               5                   10                  15      


Val Ser Arg Trp Met Gly Leu Ala Cys Phe Arg Ser Leu Ala Ala Ser 
            20                  25                  30          


<210> 122
<211> 29
<212> PRT
<213> Homo sapiens

<400> 122
Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser 
            20                  25                  


<210> 123
<211> 41
<212> PRT
<213> Homo sapiens

<400> 123
Met Val Ser Ala Leu Arg Gly Ala Pro Leu Ile Arg Val His Ser Ser 
1               5                   10                  15      


Pro Val Ser Ser Pro Ser Val Ser Gly Pro Ala Ala Leu Val Ser Cys 
            20                  25                  30          


Leu Ser Ser Gln Ser Ser Ala Leu Ser 
        35                  40      


<210> 124
<211> 20
<212> PRT
<213> Homo sapiens

<400> 124
Met Met Gly Ser Pro Val Ser His Leu Leu Ala Gly Phe Cys Val Trp 
1               5                   10                  15      


Val Val Leu Gly 
            20  


<210> 125
<211> 23
<212> PRT
<213> Homo sapiens

<400> 125
Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Ala Phe Ser Ala Thr Gln Ala 
            20              


<210> 126
<211> 45
<212> PRT
<213> Homo sapiens

<400> 126
Met Val Leu Met Trp Thr Ser Gly Asp Ala Phe Lys Thr Ala Tyr Phe 
1               5                   10                  15      


Leu Leu Lys Gly Ala Pro Leu Gln Phe Ser Val Cys Gly Leu Leu Gln 
            20                  25                  30          


Val Leu Val Asp Leu Ala Ile Leu Gly Gln Ala Thr Ala 
        35                  40                  45  


<210> 127
<211> 68
<212> PRT
<213> Homo sapiens

<400> 127
Met Asp Phe Val Ala Gly Ala Ile Gly Gly Val Cys Gly Val Ala Val 
1               5                   10                  15      


Gly Tyr Pro Leu Asp Thr Val Lys Val Arg Ile Gln Thr Glu Pro Leu 
            20                  25                  30          


Tyr Thr Gly Ile Trp His Cys Val Arg Asp Thr Tyr His Arg Glu Arg 
        35                  40                  45              


Val Trp Gly Phe Tyr Arg Gly Leu Ser Leu Pro Val Cys Thr Val Ser 
    50                  55                  60                  


Leu Val Ser Ser 
65              


<210> 128
<211> 49
<212> PRT
<213> Homo sapiens

<400> 128
Met Glu Lys Pro Leu Phe Pro Leu Val Pro Leu His Trp Phe Gly Phe 
1               5                   10                  15      


Gly Tyr Thr Ala Leu Val Val Ser Gly Gly Ile Val Gly Tyr Val Lys 
            20                  25                  30          


Thr Gly Ser Val Pro Ser Leu Ala Ala Gly Leu Leu Phe Gly Ser Leu 
        35                  40                  45              


Ala 
    


<210> 129
<211> 15
<212> PRT
<213> Homo sapiens

<400> 129
Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys 
1               5                   10                  15  


<210> 130
<211> 26
<212> PRT
<213> Homo sapiens

<400> 130
Met Gly Ile Gln Thr Ser Pro Val Leu Leu Ala Ser Leu Gly Val Gly 
1               5                   10                  15      


Leu Val Thr Leu Leu Gly Leu Ala Val Gly 
            20                  25      


<210> 131
<211> 25
<212> PRT
<213> Homo sapiens

<400> 131
Met Ser Asp Leu Leu Leu Leu Gly Leu Ile Gly Gly Leu Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Leu Ala Phe Ala 
            20                  25  


<210> 132
<211> 29
<212> PRT
<213> Homo sapiens

<400> 132
Met Glu Thr Val Val Ile Val Ala Ile Gly Val Leu Ala Thr Ile Phe 
1               5                   10                  15      


Leu Ala Ser Phe Ala Ala Leu Val Leu Val Cys Arg Gln 
            20                  25                  


<210> 133
<211> 35
<212> PRT
<213> Homo sapiens

<400> 133
Met Ala Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly 
        35  


<210> 134
<211> 57
<212> PRT
<213> Homo sapiens

<400> 134
Met Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys 
1               5                   10                  15      


Val Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu 
            20                  25                  30          


Gln Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu 
        35                  40                  45              


Ala Thr Val Leu Phe Leu Ile Gly Ala 
    50                  55          


<210> 135
<211> 36
<212> PRT
<213> Homo sapiens

<400> 135
Met Ala Leu Pro Gln Met Cys Asp Gly Ser His Leu Ala Ser Thr Leu 
1               5                   10                  15      


Arg Tyr Cys Met Thr Val Ser Gly Thr Val Val Leu Val Ala Gly Thr 
            20                  25                  30          


Leu Cys Phe Ala 
        35      


<210> 136
<211> 21
<212> PRT
<213> Homo sapiens

<400> 136
Met Lys Lys Trp Phe Val Ala Ala Gly Ile Gly Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Ser Ser Ala Ala 
            20      


<210> 137
<211> 21
<212> PRT
<213> Homo sapiens

<400> 137
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala 
            20      


<210> 138
<211> 21
<212> PRT
<213> Homo sapiens

<400> 138
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala 
            20      


<210> 139
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 139
Met Lys Lys Leu Met Leu Ala Ile Phe Phe Ser Val Leu Ser Phe Pro 
1               5                   10                  15      


Ser Phe Ser Gln Ser 
            20      


<210> 140
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bacterial signal sequence

<400> 140
Met Lys Lys Asn Ile Ala Phe Leu Leu Ala Ser Met Phe Val Phe Ser 
1               5                   10                  15      


Ile Ala Thr Asn Ala Tyr Ala 
            20              


<210> 141
<211> 32
<212> PRT
<213> Homo sapiens

<400> 141
Met Phe Ala Lys Arg Phe Lys Thr Ser Leu Leu Pro Leu Phe Ala Gly 
1               5                   10                  15      


Phe Leu Leu Leu Phe His Leu Val Leu Ala Gly Pro Ala Ala Ala Ser 
            20                  25                  30          


<210> 142
<211> 19
<212> PRT
<213> Homo sapiens

<400> 142
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 143
<211> 19
<212> PRT
<213> Homo sapiens

<400> 143
Met Arg Phe Pro Ser Ile Phe Thr Thr Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 144
<211> 19
<212> PRT
<213> Homo sapiens

<400> 144
Met Arg Phe Pro Ser Ile Phe Thr Ser Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 145
<211> 19
<212> PRT
<213> Homo sapiens

<400> 145
Met Arg Phe Pro Ser Ile Phe Thr His Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 146
<211> 19
<212> PRT
<213> Homo sapiens

<400> 146
Met Arg Phe Pro Ser Ile Phe Thr Ile Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 147
<211> 19
<212> PRT
<213> Homo sapiens

<400> 147
Met Arg Phe Pro Ser Ile Phe Thr Phe Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 148
<211> 19
<212> PRT
<213> Homo sapiens

<400> 148
Met Arg Phe Pro Ser Ile Phe Thr Glu Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 149
<211> 19
<212> PRT
<213> Homo sapiens

<400> 149
Met Arg Phe Pro Ser Ile Phe Thr Gly Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 150
<211> 21
<212> PRT
<213> Homo sapiens

<400> 150
Met Arg Ser Ser Pro Leu Leu Arg Ser Ala Val Val Ala Ala Leu Pro 
1               5                   10                  15      


Val Leu Ala Leu Ala 
            20      


<210> 151
<211> 22
<212> PRT
<213> Homo sapiens

<400> 151
Met Gly Ala Ala Ala Val Arg Trp His Leu Cys Val Leu Leu Ala Leu 
1               5                   10                  15      


Gly Thr Arg Gly Arg Leu 
            20          


<210> 152
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 152
Met Arg Ser Ser Leu Val Leu Phe Phe Val Ser Ala Trp Thr Ala Leu 
1               5                   10                  15      


Ala 
    


<210> 153
<211> 32
<212> PRT
<213> Homo sapiens

<400> 153
Met Leu Arg Gly Pro Gly Pro Gly Arg Leu Leu Leu Leu Ala Val Leu 
1               5                   10                  15      


Cys Leu Gly Thr Ser Val Arg Cys Thr Glu Thr Gly Lys Ser Lys Arg 
            20                  25                  30          


<210> 154
<211> 26
<212> PRT
<213> Homo sapiens

<400> 154
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala 
            20                  25      


<210> 155
<211> 31
<212> PRT
<213> Homo sapiens

<400> 155
Met Arg Arg Gly Ala Leu Thr Gly Leu Leu Leu Val Leu Cys Leu Ser 
1               5                   10                  15      


Val Val Leu Arg Ala Ala Pro Ser Ala Thr Ser Lys Lys Arg Arg 
            20                  25                  30      


<210> 156
<211> 2267
<212> DNA
<213> Homo sapiens

<400> 156
gagccgctcc tgacccacct accccagctc tcgcgccgcg tgcagaggtg ctcaagcctc       60

ctcgcggtcc gcagtcagtg ccgccgcgcc cggcctcccg cacgccccgc aggtagcgcc      120

cccgcccgcg gcccagagtg cgctcgcgcc ggcaccagct cccggataaa cggcgcgccg      180

cgcggagatg acagccgagg agatgaaggc gaccgagagc ggggcgcagt cggcgccgct      240

gcccatggag ggagtggaca tcagccccaa acaggacgaa ggcgtgctga aggtcatcaa      300

gagagagggc acaggtacag agatgcccat gattggggac cgagtctttg tccactacac      360

tggctggcta ttagatggca caaagtttga ctccagtctg gatcgcaagg acaaattctc      420

ctttgacctg ggaaaagggg aggtcatcaa ggcttgggac attgccatag ccaccatgaa      480

ggtgggggag gtgtgccaca tcacctgcaa accagaatat gcctacggtt cagcaggcag      540

tcctccaaag attcccccca atgccacgct tgtatttgag gtggagttgt ttgagtttaa      600

gggagaagat ctgacggaag aggaagatgg cggaatcatt cgcagaatac agactcgcgg      660

tgaaggctat gctaagccca atgagggtgc tatcgtggag gttgcactgg aagggtacta      720

caaggacaag ctctttgacc agcgggagct ccgctttgag attggcgagg gggagaacct      780

ggatctgcct tatggtctgg agagggccat tcagcgcatg gagaaaggag aacattccat      840

cgtgtacctc aagcccagct atgcttttgg cagtgttggg aaggaaaagt tccaaatccc      900

accaaatgct gagctgaaat atgaattaca cctcaagagt tttgaaaagg ccaaggagtc      960

ttgggagatg aattcagaag agaagctgga acagagcacc atagtgaaag agcggggcac     1020

tgtgtacttc aaggaaggta aatacaagca agctttacta cagtataaga agatcgtgtc     1080

ttggctggaa tatgagtcta gtttttccaa tgaggaagca cagaaagcac aggcccttcg     1140

actggcctct cacctcaacc tggccatgtg tcatctgaaa ctacaggcct tctctgctgc     1200

cattgaaagc tgtaacaagg ccctagaact ggacagcaac aacgagaagg gcctcttccg     1260

ccggggagag gcccacctgg ccgtgaatga ctttgaactg gcacgggctg atttccagaa     1320

ggtcctgcag ctctacccca acaacaaagc cgccaagacc cagctggctg tgtgccagca     1380

gcggatccga aggcagcttg cccgggagaa gaagctctat gccaatatgt ttgagaggct     1440

ggctgaggag gagaacaagg ccaaggcaga ggcttcctca ggagaccatc ccactgacac     1500

agagatgaag gaggagcaga agagcaacac ggcagggagc cagtctcagg tggagacaga     1560

agcatagccc ctctccacca gccctactcc tgcggctgcc tgccccccag tctccccact     1620

ccaccctgtt agttttgtaa aaactgaaga attttgagtg aattagacct ttatttttct     1680

atctggttgg atggtggctt taggggaagg gggaaaggtg taggctgggg gattgaggtg     1740

gggaatcatt ttagctggtg tcagcccctc ttcccttcct ccattgcaca tgaacatatg     1800

tccatccata tatattcatc agaatgttaa tttattttgc tccctctgtt aggtccattt     1860

tctaagggta gaagaggcaa gtggtaggga tgaggtctga taagaaccca gggtggagag     1920

ggagactcct gggcagccgt tttcctcatc ctttccctct cccagtccat ttccaaatgt     1980

ggcctccatg tgggtgctag ggacatggga aaaaccactg ctatgccatt tcttctctct     2040

gttcccttcc tcacccccga cggtgtggct gatgatgtct tctggtgtca tggtgaccac     2100

cccctgttcc ctgttctggt atttcccctg tcagtttccc ctctcggcca ggttgtgtcc     2160

caaaatcccc tcagcctctt ctctgcacgt tgctgaaggt ccaggcttgc ctcaagttcc     2220

atgcttgagc aataaagtgg aaacaataaa acctgggtgt cagacaa                   2267


<210> 157
<211> 2079
<212> DNA
<213> Homo sapiens

<400> 157
gccgcggccc cccggttgct gccccgatgc gctgcgcccg gagccggggc cgagtcgctg       60

ccgcagctgt tggggcgccc gggccaggcg acgccgccgt cgcccgtgcc cctcccagac      120

cgcaccggcc gcatggagcc cccggagggc gccggcaccg gagagatcgt taaggaggct      180

gaggtgccgc aggctgcgct gggcgtccca gcccagggga caggggacaa tggccacacg      240

cctgtggagg aggaggtcgg gggcatccca gtaccagcac cggggctcct gcaggtcacg      300

gagaggaggc agcctctgag cagcgtctcc tctctggagg tccacttcga cctcctggac      360

ctcactgagc tcaccgacat gtcggaccag gagctggccg aggtctttgc tgactcggac      420

gacgagaacc tcaacaccga gtccccagca ggtctgcacc cgctgccccg ggccggctac      480

ctgcgctccc cttcctggac gaggacaagg gctgagcaga gccacgagaa gcagccccta      540

ggcgaccccg agcggcaggc cacagtcctg gacacgtttc tcactgtgga gaggccccag      600

gaggactaga ccatctccac ctgccccagc tcctgcaggg atggggtccg aacacgatgg      660

cagatctggg cagtgctgac ccagcagaca cacttcaccc gcccacgagg ctccagccgt      720

cacctcctga cacacaccct gggggcagct ctctgccagc cccgagaccg gccttgtctg      780

ctgggcacgg gtcttcgcct cacttggaga ccagccggct ttcctggggg acacacgggg      840

cccccggatg cctctgggag ccccagcaca agcacagccc agtggcctta cgtccagctc      900

gttcctgggc cccgagtcag gaagacagcg tcacggagtc actgccagga acgtgctgag      960

gaatggagtg gcccacggcg gccttggggt gaaggggacc caggcctgtg acagccactc     1020

caggaactcc tgggggtgct ccaacctccg cgttttcctg tgctgccaag ctcagaagcc     1080

agaggcgggt ttggtagtgg ctaatgggac aatgtgctgt ccagcaaagc acacatggag     1140

aagcggcccc aaaattccca ccttgatttc catcctgccc cttcttctac tccacggagg     1200

cgctgtctca ctagggtccc ctccccaagg ctcagctcta agacctgcac ctgcttctct     1260

tggcccctgc gtgacagaca agtccattcc ctccttagct cagaacacca aatatcacca     1320

gactgcctaa gagacttgat gacacctccc ggaatgctct cggggtgggg ttcacctctc     1380

cttgtcctgc acccactgct aggccacatt ctcgtttctg ctcacatccc attgcccggc     1440

tacaaggcct gcccacggcc cttaaacttg ctgggcaggt ttggagccca tgggaccccg     1500

tgggtctctg tccaggagca gcagaggagg ctgacaggcc ctgctccctc tgctctgggg     1560

gtgtctggga gccccagctc acaccctccc aatgcttata tgctgaagct cacagaatgg     1620

gcttcttgcc tgacagcaag tcaaagaatg agtttaatat caaagtgtaa gcttactttc     1680

catccccaag ccagcctgcc ccctgcccca tttcccatga gcacacttct ggggaaggaa     1740

aacaggctcc tggccttcac tctcagcaga gctttggaga tgccccaggc atgccctgag     1800

ctccttctgt gtacctgctc ccacttctga gccacccgct gcccctccgc actgctggca     1860

aacccagttc ctgcctcagc caggtctcct tccctggttt ccagtcacac agagcccagc     1920

agctttctct ttcagtccca taagggcagc cttgtgtccc tggccacact tccacccgcc     1980

agggtcttcc tccccatctt tccatccttc ctgctgagct tccacagagc tcgtttgcaa     2040

acagggggat taaagcatca ctgcgcattc gaaggcctg                            2079


<210> 158
<211> 2224
<212> DNA
<213> Homo sapiens

<400> 158
tatttgatag gaaaatttaa aatgctaaag gaaaaatttt cttagcaatt tcacaggaaa       60

acctaagttt taagagaggt tatcattctg actgggaact gaactattat gactaggtct      120

ataatttaat aacaagtcac aatatctctc tttcttgaca tcaatttaag gtgacttttc      180

acatagtaga gagaatggct tcagttatac ctgcctccaa taggtccatg agatctgaca      240

ggaatacata tgttggaaaa aggtttgttc acgttaaaaa tccttacttg gatttgatgg      300

atgaagacat tctctatcac ttggatttgg gaacaaaaac acacaaccta ccagcaatgt      360

ttggagatgt aaagtttgtc tgtgtcggtg ggagccccaa cagaatgaaa gcatttgcac      420

tgtttatgca caaggagctc gggtttgagg aagctgaaga agacataaaa gacatctgtg      480

ctgggacaga cagatactgt atgtacaaaa ccgggcctgt gctcgccatc agtcacggca      540

tgggcatccc ctccatttct attatgcttc atgaactcat caaattactc caccatgcac      600

ggtgctgcga tgtcaccatt attagaatcg gtacatcagg gggaataggg attgcaccag      660

ggactgttgt aataacggat atagctgtag actccttctt taagccccgg tttgaacagg      720

tcattttgga caacattgtc acccgaagta ctgaactgga caaagaactg tctgaagaac      780

tgttcaactg tagcaaagaa atccccaact tcccaaccct cgttggacat acaatgtgta      840

cctatgattt ttatgaaggc caaggccgac tagatggagc actgtgctcc ttttccagag      900

aaaaaaagtt agactacttg aagagagcat ttaaagctgg tgtcaggaat attgaaatgg      960

aatctacagt gtttgcagct atgtgtggac tctgtggtct aaaagctgct gtggtctgtg     1020

tgacacttct cgacagactc gactgtgatc agatcaactt gcctcatgat gtcctggtgg     1080

agtaccagca acggcctcag ctcctaatct ccaacttcat cagacggcgg cttggacttt     1140

gtgactagac gtcctaactg ggcagcccaa ccctcccctg caagtttgta gctcaagttg     1200

taatgtgaaa gtcatatttt atttgtggca tttttatata gttctcatcc acatgctaaa     1260

tggaaagact ttatgaaatc cttctctctt aaaaaggaat ttattgtaaa agaatactca     1320

cactaaatta aattcaaatt tcattttaga ataagttaac taaatcagtc taataattaa     1380

aattttaaaa ctcctggatt atgacatttg gagtttcata tgcagcatta attaagctca     1440

catcaaaata gaccagccat ttgcacatag ttaccagtca ctctgtttct gaaaccaatc     1500

cagaaattca tgttagaaca ttgtcaggca cttctaggta ttggacaagt gacagaaact     1560

gatcatccat attcaaaata tttacagaaa aaagtgtcag tgaaatgtag gtctatatgg     1620

aaaagttacc attaggaaaa tatggccata ctgctttttt acccctgcac tatttcagtg     1680

caccacagaa taggattcga gatttacata tgcctgtttg tgattttatc tcagaatata     1740

acaactctgg attacatttt cctctcaact gaaaaccctc agtaatgcaa agaaaggcct     1800

tcctttttct tcagaatcac aagtgactaa attgccttct agccattttt tcttgtaaaa     1860

aaagtgtttt gaggaggctg tattttttat tccatttcaa tattaaccaa ataggctgag     1920

aaattcatag caattgaatt aagacttgag ttcaagatgt taaaggaatc cttttgtatg     1980

acttgtccag accggcctat tgccctaccc gtttgattct ctgggaggca tggtgctcct     2040

cctggctgca catgctctct gtgaactgat cgcatcttgg gttcttctca atttgacata     2100

cttgggagtc ggaatgactg gatgggggat gggtagagga tgactggcac acttgtatag     2160

tatgtaatgt tgtgtacata ttatttatat ggttgtggct caaataaagt ttaattccaa     2220

caca                                                                  2224


<210> 159
<211> 1583
<212> DNA
<213> Homo sapiens

<400> 159
gagccggggg gaggggccgg ggcggtggcg gctgtggccg gtactggacc cggcgggatg       60

agcgaggtgg aggcggcagc gggggctaca gcggtccccg cggcgacggt gcccgcgacg      120

gcggcagggg tggtagcggt ggtggtaccg gtgcccgcag gggagccgca gaaaggcggc      180

ggggcgggcg gcgggggcgg agccgcctcg ggccccgctg ctgggacccc ctcggcgccg      240

ggctcccgca cccctggcaa tccggcgacg gcggtctcgg gaacccccgc ccccccggcc      300

cggagtcagg cggacaagcc ggtgctggca atccaagtcc tgggcactgt caaatggttc      360

aacgtccgga atggttacgg attcatcaac aggaatgaca ccaaggaaga tgtctttgtt      420

caccagacag ctattaaaag aaacaacccc aggaagtttc tgcgcagcgt tggagatggg      480

gagactgtgg aatttgatgt cgtggaagga gagaagggcg cagaagccac taatgtaact      540

gggcctgggg gagtacccgt gaagggcagc cgttatgccc ccaaccgacg taagtcccgc      600

cgattcatcc cccggcctcc ctcagttgcc ccaccaccca tggtggcaga gatcccctcg      660

gcggggacag gacctggcag taaaggggag cgggctgaag actctgggca acggccccga      720

cgatggtgcc ccccaccctt cttctaccga cggcggtttg tgcgaggccc ccggcctccc      780

aaccagcagc agcctataga gggcactgac agggtagaac ccaaagagac agccccattg      840

gaggggcacc aacagcaggg agatgagcga gtccccccgc ccagattccg gcccaggtac      900

cgaaggcctt tccgccccag gccacgccag cagcctacca cagaaggtgg ggatggtgag      960

accaagccca gccaaggtcc cgctgatggt tcccggcctg agccccagcg cccacgaaac     1020

cgcccctact tccagcggag acggcagcag gcccctggcc cccagcaggc ccctggcccc     1080

cggcagcccg cagcccctga gacctcagcc cctgtcaaca gtggggaccc caccaccacc     1140

atcctggagt gattccaact caactcagag gacacccaga gctgccatct ggtatctgcc     1200

agtttttcca aatgacctgt accctaccca gtaccctgct ccccctttcc cataattcat     1260

gacatcaaaa caccagcttt tcaccttttc cttgagactc aggaggacca aagcagcagc     1320

cttttgcttt ttcttttttc ttccctcccc ttatcaaggg ttgaaggaag ggagccatcc     1380

ttactgttca gagacagcaa ctccctcccg taactcaggc tgagaaggaa ccagccagct     1440

cttacctcct cctggttgct tttcttgccc ccaccccaag tttatttttg ttttcccccg     1500

gccccctacc tctgaagcca ttttatgatc tgtcatgtgc cacctgagcc tccagtaaaa     1560

acaaaaacag gctttcctgt ggt                                             1583


<210> 160
<211> 9913
<212> DNA
<213> Homo sapiens

<400> 160
gcttgcttgc ccggctcgct cacgggtcgt tgaggccggt gacatgtctg tgagctgcgg       60

aggctgcggc ccccagatct ttctctttga cactttgcaa taaaaaaggg cagtgagatt      120

gaataggtgt tttgtggatt aactcttcat tgattatata caacaaaaaa tagttatggc      180

gactttcaga aacaatcaca tgaagactaa agcatctgtc agaaaaagct tcagtgaaga      240

tgtgttccag tctgtaaagt ctttattgca gagtcagaag gaactatgca gtgtaacagc      300

agaggactgt ttacagcagg atgagcatgc caatttaact gaggtcacat ttctgggttt      360

taatgaagag acagatgctg ctcatataca ggatttagct gcagtttctt tggaacttcc      420

agatattctg aattcactcc acttctgcag tctaaatgaa aatgaaatta tttgtatgaa      480

gaatataaat aaaccattag atataagcag tgatcctcta aatcagagtc atccttctgg      540

aatgctttgt gtcatgagag tgtcacctac atcaccaaga cttaggattg attttatctt      600

tagtctccta agtaaatatg ctactggtat aaggtacacc ttggacacat tcttgcatca      660

gaagcaccaa cttgagacca ctgatgaaga tgatgatgat actaaccagt ctgtgtcatc      720

catagaggat gactttgtca ctgcttttga gcacttagaa gaggaagaga cttcaaagcc      780

atacaatgat ggaatgaaca ttactgtgct aaggagccag tgtgatgctg cttcccagac      840

ggttactggt catcatttag aaacccatga tttaaagatt ctcattagct ctggacagca      900

gaagtcattg gctaaaccct caacttcctc agtgaatgtc ctgggacata aagaactacc      960

ttctgtgaaa acttcagtca caacatcaat ttcagagcct tggacccaaa ggagtttcta     1020

taggtcatct aatgcttcag ataaagatag tgatttacag aaaacatttt tttcgtcttc     1080

tcctgcctac tcatctgaat cagaatgttc aagtccaagt cctgttattt tcttggatga     1140

agagggatat caaaaaagct taaaagcaaa acttgagctg cctaaaattc ctgtgatgaa     1200

agatgatata gaggattcag actcagaagt aagtgaattt tttgatagtt ttgatcagtt     1260

tgatgaacta gaacaaactt tagagacttg cctgtttaac aaagatcccg tcatagggaa     1320

gtcatcgcag aggaaagggc acaaacatgg aaagtcatgt atgaatcctc aaaaattcaa     1380

gtttgatcgt ccagctctcc cagctaatgt tagaaagcca actcctcgta aaccagaatc     1440

tccatatggt aacctgtgtg atgctccgga ttctcctcgc ccagtgaagg catcaaggga     1500

agatagtggt ttatttagtc ctattcgatc ctctgctttt agtcctcttg gaggctgtac     1560

tccagctgaa tgtttttgcc aaacagatat tggtggagat aggattcatg aaaatcatga     1620

ttctgtttat tacacctatg aagactatgc aaaaagcatt tcatgtgaag tactaggctc     1680

agttcttcgt acccaccata ctaataccct atcaaatatt aacagtatta aacatggaga     1740

aaataaaact gtaactttta agcatggaaa ccttgatcaa aaaaataaat ctaaaaataa     1800

atccttaatg attaaagata gcattcaaaa atttgcagca gatcttgtgg aaaaaagttt     1860

tggcagtgca tttaaagact tacagaaagg agtctcttca tgtaccaatg ctttgtacca     1920

cttagccatc aaattgacat catctgtttt gcagatggca tttgatgagc tgagaaggca     1980

gcgtgcattt tcactaaaag aacgtgccat tagtggcctg gctaactttt tggtgagtga     2040

agctttatca aatgccttaa aagatttaca gtatgtaaag aagcagatat tcacaaacac     2100

agttgctagg tttgctgcag atcttgctga agagcttgtt tttgaaggca tcatggaggt     2160

gtgtcagttt tcatatcctc aaacgcctgc atctccacag tgtgggtcgt ttgactttga     2220

agacaaagta gtgaagttgt atgcaaaaga tttgtctgaa tctgtaatac aggaagcatt     2280

cattgagcta tcacaagttg atgtgacctt tacaacaaag gcagcagtta gtgtctctac     2340

ggataatatc aagtatgtga gtgcagaaag tgtagtgcca tcgacacagg ctgtcacgtt     2400

ttccccttct tttcacaatc aagcaattat ggtgacaaaa ccagtgcagg aatataaaaa     2460

ggaatacaca gtgcagcagg ccttgttttg tacttctgga attgttactt ctataccggt     2520

gcccttggca ggaagtgccc ttctcccata tcatatttca tctactgcat gtcaggccaa     2580

ggctcatctg tcatctgatg atagtaattc aaatggtgat tctgcccaag tgcatattgc     2640

cacaaaaaac agagaagaaa aagcagcttg tctcagaaat atttgtttac cttcagaaca     2700

caatccaggt aatcagaatg attttaaacc aactaatgac gatattgaaa tgcagagttc     2760

ctcaaaatta ccaaatgatc ctgcaattat tagcaacttt tctgcagcag tggtgcatac     2820

gatagtaaat gaaactttag agtcaatgac atcattggaa gttacaaaaa tggttgatga     2880

acgtacagat tatttaacta aatctttaaa ggagaaaacc cctccatttt cccactgtga     2940

tcaggcagtg ctgcaatgca gtgaagctag tagcaataag gacatgtttg ctgaccggtt     3000

atctaaatct attattaaac attccataga taagagcaaa tcagtgatcc caaatataga     3060

taaaaatgca gtatacaagg aaagcttgcc tgtttctgga gaagaatcac agttgacacc     3120

agaaaagtct cccaaatttc ctgactctca gaatcagtta actcactgct cactttcagc     3180

tgcaaaggat tgtgttccag aatgtaaagt ttctatggtt catggatcct ccctagagac     3240

actgccatct tgtccagctg tgacaggtca gaaatctgac ttgaaggaat ctgctaagga     3300

tcaaccactg aaaaagcata acttgaatag tacatcactt gaggccttgt cttttggaca     3360

ggaaaacccc tttcctcatt cacatacttt ctcatctaca gcacttacct gtgtagatgg     3420

tttgcatgtg gaagataaac agaaagtcag agacagaaat gtaatacctg atactcctcc     3480

atcaactcct ctagtaccat cccgggctag ttctgaatgg gatatcaaga agttaactaa     3540

aaagctcaag ggagaattag ccaaagagtt tgcacctgct acaccacctt ctactccaca     3600

caactcatct gttggtagtt tgtctgagaa tgaacaaaat actatagaaa aagaagagtt     3660

catgttgaaa ctcatgcgat ctctttctga agaagttgag agtagtgaaa gtggagagct     3720

cccagaagtg gatgtgaagt cggagcactc agggaagaag gttcagtttg cagaagcatt     3780

agctacacac atcctttctc ttgcaactga aatggcagct tcccatttag ataacaaaat     3840

aattcaagaa cccaaggtta aaaacccttg cttaaatgtg caaagtcaaa gaagtgtgtc     3900

gcctactttt ttaaacccct cagacgaaaa tttgaaaaca ttatgcaatt ttgcgggtga     3960

tctggcagca gaagtcatta cagaagctga gaaaatagca aaagtccgaa attgtatgct     4020

tttcaagcaa aagaagaaca gttgttatgc tgatggtgac gaagattata aagtagaaga     4080

gaagttggat atagaggctg tagtgcaccc aagagaagtg gatccgttta ttctttcatt     4140

accaccaagt tcttgtatgt caggtctgat gtataagtat cccagctgtg aaagtgtgac     4200

agatgaatat gcaggtcacc ttattcagat actaaaacag gaaggtggta atagtgagtt     4260

gataatggat cagtatgcca ataggcttgc ctaccgatct gttaaatcag gattacagga     4320

agcagctaag acaaccaaag tgcagtgcaa ctcaagaatg ttccctgtgc caagttcaca     4380

agtgaaaaca aacaaggaac tgttaatgtt ttcaaacaaa gagcaccacc aagaagcaga     4440

caaaaagaga caaagtaaaa gaaatgaagg ttacttttgt aaaaatcaaa cttgtgaaag     4500

gaccctggat ccatatagaa atgaggtctc ccaactgtat agtttttcaa cctctctggt     4560

tcacagcata acaaaagatg ctaaggaaga gttgacagcc tctctagttg gcctaccaaa     4620

atccttaaca gattcttgct tgtttgaaaa atctggatat gaagaagata atgagtgtca     4680

cgttacacca gaattgccta agtctcttca gccttcctca caaaatcaca ggttttacca     4740

cagcactggc agtttaaatg gatatggttg tggagacaat gttgttcaag ctgtagaaca     4800

gtatgccaaa aaagtagtgg atgacactct agagctaact ctaggatcta cagtgttccg     4860

agtgtctgag accacaaaat cagcagacag ggtcacttat gcagaaaagt tgtcacctct     4920

tacaggtcaa gcttgcagat actgtgacct taaagaactc cacaattgca ctggaaattc     4980

atctcagcac tttttcagac agggttctct cgccagtagt aagccagctt ctaatccaaa     5040

atttagcagc cgctatcaga aatctaggat ttttcatctc agtgtccctc agattcatgt     5100

taatcttgat aagaaggcag tgcttgctga gaagatagtt gctgaagcca ttgaaaaagc     5160

tgagcgagag ctgagcagta ccagcctggc agccgacagt gggatcggac aggagggtgc     5220

cagctttgct gaaagccttg ccacagaaac catgacagca gctgtcacaa atgttgggca     5280

tgctgttagc agttcaaaag aaatagaaga ctttcagtca accgagtctg tcagtagcca     5340

gcagatgaac ctcagtattg gtgatgacag cactggtagc tggtccaatt taagttttga     5400

agatgaacac caagatgaaa gcagcagttt tcatcatcta agtgaaagta atggtaacag     5460

cagtagctgg agcagtcttg gtttagaagg agatttgtat gaggacaatt tatcctttcc     5520

aacatcagac agtgatggac cagatgataa agatgaagag catgaggacg aagtagaagg     5580

tttggggcaa gatggaaaga cactgctaat tacgaatatt gacatggagc catgcacggt     5640

agacccccag ctaaggatta ttcttcagtg gctcattgcc tctgaggctg aagttgcaga     5700

actttatttt catgactctg caaataagga gtttatgcta ctttcaaaac aattacaaga     5760

gaaaggatgg aaagtgggag acctcctgca ggctgtgctt caatactatg aagtgatgga     5820

aaaagcttcc agtgaggaga gatgcaagtc gctgtttgat tggctcttgg aaaatgcata     5880

gagcaaaccc caaaccagta tattttagta tttgtttggg gaggggaaca agccaataaa     5940

gatgtttagg ataaaatttg aatagtgaat attaacatcg taagtcagtt gggaggcaag     6000

taaatatagc tttctgagcg ctttgtgtta tcactcggtg tatatagttc atacttttgt     6060

aatctgtcaa aatactacct tcatttattc ttctatacac atgtgtagtg tgtcaagacc     6120

ctaagaacat gtatttgaag gaaggtctaa ccagggggtt ttcaggggca ttgtctgacc     6180

acattctttt tgtatccaaa tagtgctgct agaaactgca ctgaagtggc tgaggatagg     6240

ttccagtgat agagttataa ttttgctcct ttgcaaacaa atggtatcta attaataact     6300

agtctgacat cagaaaataa aattgaggct gatttttaaa aatttctagt agatttttgg     6360

cctttcctgt ttttaaaaat cagtttcatt ttcatatttc atagatcagc tattggtagc     6420

tttttgattt ccccaaacta tttaatttct tagcagaaac attagtattt taggtttcta     6480

taaacactat aagtgatagt ttcccccatc ctttcattga cattatttgc caatgctgcc     6540

agtcattctg gcatgaaagg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     6600

tgtaagggag tactttaacc ttgccagttt gttccctctt ttattttact gttttctttt     6660

tagaaaccca ctgttaaaat ttaaaaaggt gctttaaaat aaaacgccta taaagattgt     6720

gcagtaagaa tttttattga caataattaa aatttttttt gacaattttg ggttcccaac     6780

ttatcttaca agtgaaaact taaattgtaa aacatgttga aattttaaaa attaatgtta     6840

atatggaaat gcatttagag aagcccagta gtttttattg ttggattttt gaaaaaacct     6900

ctaccaagaa tgtggtgttt tttttgtttg tttgtttgtt tgttttagaa aaattgggat     6960

ttccccccac cccgccccac ccagataaac tatatctaca ctgtctcgtc aagttctctg     7020

acacgatctt tctgggctct acatttccta ctagtttgtg tccagaaact gcaagttgac     7080

atgaatagag gacaaaggtt gtgtcttgct tttgtctctc tcttccctcc ctgcaactct     7140

ctctcccctc ctcccactct cttccccctc ccccctcctc ccactgtctc tcacctcccc     7200

caccccccac tctctctcat ctctcgctgt gtcctgtgta tgtgtgggtg tgtgtgtatt     7260

tgggtgtgta aatgttggtt cttccactac tggattttgt aatctaggat aaatcacttt     7320

ttttggggac tttgattttg ctccattacg ttttcatttt ttctgagcac tgactgttct     7380

gaaagctgca caaaacgtag aaagaagaca tagcgcctgc cagggaatag gaaatgaggg     7440

cacttacaca ttaatgtgaa ttagtaattg tggtatagaa atgttttata gtgaaagatt     7500

caaatttgct tttcaagaaa aatgccaaaa gctatttaaa taattcgagg ttacatcgta     7560

ggttttgatt tttctcaatt taagatacag aaatacagca agccttaata taaagtttcc     7620

taaagtttct tcaagtattt tttaaggtgg agaaatgcag gaattgtata accagaattg     7680

ttcctgcctt tagcttttca gaacttgaga tgtggcagca ctggactggg tttttttaaa     7740

tgttaggact aggaatgttt gctcttgtta attatgaatt aattgattat taagtttaga     7800

atgcattttt acaagtatct aactatcaaa ttgtgtttag taacttgagt gtatgcacaa     7860

gtttgatcaa cagcaaaata gagttctgaa tttcttttaa agtgatgata tattattttg     7920

tgaaactttg tgtttgaaaa tgtttatttc tgtttatggt gtaatcattc tgaggtgagg     7980

cttttcttat ttcctttgca ttttgctaga gctgtgctga gttcagcatt tgcttattta     8040

accactacat aatgacagac cagttattag gtattagcat gtgtggtaat aataatagtg     8100

gaacttcaca cttacatcaa ttcagtgcag gggcatagaa taaaatatta aatattggca     8160

gatgtatgaa aagaagtgtg agttaaaaat attgaatatt ggcaggtgtg aaaacaagtg     8220

tcaaaattcc tcatatagag aaaataattt tgagtttaga gtattatctt ttaattaagt     8280

gtagtctaaa cttaactttc tgtaaaggca ctttgtggtt tttccaaaga tgttctagat     8340

ctatttggtt gctctatagt caaacagctc ttttgaagac aactgtctta ttttattaca     8400

aattggcttg acatatttat actgtaacat tgtaatattg ctgtgctgta cattttggcc     8460

cttacgaaat acgtcttttt cagaactgtt aaagttttga tgtacatcga gctgaattct     8520

gtttttacca gtttcaaaac cttcaagtga tatgtggaaa aaagtgaatg agacctctga     8580

tagggggttt tcagaacctt gttcacacca aaatgtgaca gttctttcat gttttcctaa     8640

accaagttaa aattacatgt atattttggt gttaaggttg atttttaaga tacttctgat     8700

ttgtacaaaa ggaatgtttc ctttataaat cacagaagaa aatgacaata tctgttggat     8760

atttgatata atttaatggt gttataaaac ctttaagagg attcatggtg aatatatgtg     8820

ataacatctt tatactttga aaaatgttcc acttaccctt cagatatttg ttgtaagtta     8880

attcaattct taatacttta attttgctcc aacaagggct ttatgttgct ggtaagagaa     8940

tttatttact aaatgcacta tgtataaagt gaaagatagt ttacttatct gactttgata     9000

ttagatggct gacattagtg cacataatgc agagtttaac cttgattctt caacagagtc     9060

cagatttaaa tgtctactta gttaattagt tagctgatat tcttccacaa ttaatatatt     9120

caatttccca tcagtatatc actttaaatt ttatgttttt ctaaggaaac tttccacaga     9180

attttaaaca actgatgcat ccatactcag ggtgtaggga gaatactttg catttaaaaa     9240

ccctgtccac ctgtcaccag cacaagagaa ttagagcttc agtgagaatt tagaaaaatt     9300

atactaaagt gagatgcatt ttttctcatt ttcagcaaga ctcctctaag catttactca     9360

tttactgtat tcctgctctg aagatgtgga tacagaatta gtcactcttg tcactttatt     9420

tatttattgg ttttttttta accatctgtg tacattcctt tcatagggta gagttctagt     9480

tctagaagtt cttattttgt ttttgttgta atgtttgaat actatttaat atccggtttt     9540

aatattgctg gatttgctac ctttggttac ttgtgcagtg ttaaaagtaa tccactttct     9600

tgtttaatat accagataca tagcaaaagc agcttggaat aattatagct gtttatttgg     9660

ctgtgctcag ttactatatt aagatcttgt actgtgtaac agtaactctt ttttgctttt     9720

cagtaattta atatgttcac ttaacaaaat acgaactttg agatgcacta aagttttgtt     9780

tcagcagtgg ctcaaaaaat ttcagaaatt acttttgtaa ttatttgcaa ttaattgttc     9840

ttttatctta caattgttta agcctgtgat ctttcttctc ccagctaaga gttcttcaat     9900

aaatttaaga aat                                                        9913


<210> 161
<211> 1810
<212> DNA
<213> Homo sapiens

<400> 161
gggcggtgag ggggcgggcc cgtacgccga ttccatatgg gcgccggcgc ggagcgccgc       60

ggggcagcgc ggggtcgcca tggctgagct gcagcagctc cgggtgcagg aggcggtgga      120

gtccatggtg aagagtctgg aaagagagaa catccggaag atgcagggtc tcatgttccg      180

gtgcagcgcc agctgttgtg aggacagcca ggcctccatg aagcaggtgc accagtgcat      240

cgagcgctgc catgtgcctc tggctcaagc ccaggctttg gtcaccagtg agctggagaa      300

gttccaggac cgcctggccc ggtgcaccat gcattgcaac gacaaagcca aagattcaat      360

agatgctggg agtaaggagc ttcaggtgaa gcagcagctg gacagttgtg tgaccaagtg      420

tgtggatgac cacatgcacc tcatcccaac tatgaccaag aagatgaagg aggctctctt      480

atcaattgga aaataaaagt atttgccagt ggccatcagg gctgagggca agaatatatt      540

ttttataagg aattgggaat tttagtcttt taagcaaagt ttacgaatga agaaatgaag      600

gatggccaca agcgtaaggc atatgtcact tgcctctgga cactggttat tttatgtttc      660

agtccctaaa aaatgaaatg gaaaaaagtg gtgctaaatc gagtcagaga tattacagga      720

gagttttaga gcttattatt tcctgtggcc agtgcttgtc ctggcagtaa ggctttcccc      780

tgtaacaagc cagagccctc caaggtacca gactcttctt actacacagg tactaacagg      840

ctggcaggtt agagttggtg gagtctgagg agagatattt tctctttgtt gccaacatcc      900

tgtttaccaa aagtgtcacc ccaccatctt ccataagctg tgaaacaaaa tcaatgaggt      960

cactaactta gaagggaaag aaagttttct gggtctttgt tttcttgatt tggggtaatt     1020

tatacaaggg catacaagtt gattttaaga tgtggaactg ggaggtagac tagtttggat     1080

aagaactttg aaatgttcct tgtggatccc catttctggt catcaagatg tggatgtaca     1140

tttcttaaaa ttattacatg ctgcatcttt cagcctggag actgtgcaga aacatgagag     1200

gtgatgacac actaattatg ggaagcagaa ttactggctg atggcccctg aggctgtgtg     1260

taacaaaatg acaggacaat cttgcagtaa cactttcccc ttgaagagaa gggggttttg     1320

attgtgatat atactagtat ctaggaatga acagtaaaag aggagcagtt ggctacttga     1380

ttacaacaga gtaaatgaag tactggattt gggaaaacct ggttttatta gaacatatgg     1440

aatgaaagcc tacacctagc attgcctact tagccccctg aattaacaga gcccaattga     1500

gacaaacccc tggcaacagg aaattcaagg gagaaaaagt aagcaacttg ggctaggatg     1560

agctgactcc cttagagcaa aggagagaca gcccccatta ccaaatacca tttttgcctg     1620

gggcttgtgc agctggcagt gttcctgccc cagcatggca ccttattgtt ttgatagcaa     1680

cttcgttgaa ttttcaccaa cttattactt gaaattataa tatagcctgt ccgtttgctg     1740

tttccaggct gtgatatatt ttcctagtgg tttgacttta aaaataaata aggtttaatt     1800

ttctccccac                                                            1810


<210> 162
<211> 3177
<212> DNA
<213> Homo sapiens

<400> 162
ccccgctccc aagtgcgcgc ggacccctag ctccctctga gttgcgctgg gcttggctgc       60

tgcaccatga ccctggaggc gatccgctac tcgcggggct ccctgcagat cctagaccag      120

ctgctgctgc ccaagcagag ccgctacgag gcggtgggct cggtgcacca ggcctgggag      180

gccatccgcg ccatgaaggt gcggggcgcc ccggccatag ccctggtggg ctgtctcagc      240

ctcgccgtgg agctgcaggc gggcgccggg ggaccgggac tcgccgcgct cgtggccttc      300

gtgcgcgaca agctgagctt cctcgtcacc gcccggccca ccgctgtcaa catggcccgc      360

gccgcccgcg acctggctga tgttgcagcc cgggaggccg aacgggaggg cgctacggaa      420

gaggcggtcc gggagagagt gatctgctgc accgaggaca tgctggagaa agacctcaga      480

gacaaccgaa gcattgggga cctaggagcc cgccacctcc tggagcgggt ggcccccagc      540

ggtggcaagg tgactgtgct gacccactgt aacactggtg ctctggccac cgctggctat      600

ggtacagccc taggtgtgat tcgctcactg cacagcctgg gccgcctgga gcatgccttc      660

tgcacagaga cccggcccta caaccaggga gcccggctga cggcctttga gctggtctat      720

gagcagatcc ccgccaccct tatcaccgac agcatggtgg ctgctgccat ggcccatagg      780

ggcgtgtcag ctgtggtcgt gggagctgac cgcgtggttg ccaacggcga cacagccaac      840

aaggtgggca cctaccagct ggccattgtc gccaagcacc atggcattcc cttctacgtg      900

gctgccccca gctcttcatg tgacctccgt ctggagaccg gcaaggagat cattattgaa      960

gagcgaccgg gccaggagct gaccgatgtt aatggggtcc ggattgcagc acctgggatt     1020

ggagtttgga atcctgcctt cgatgtcacc ccccacgacc tcatcactgg tggcatcatc     1080

acagaactgg gggtctttgc ccctgaggag ctccggacag ccctaaccac caccatctct     1140

tccagggatg gaaccctaga tggaccccag atgtaaccaa ctcagctctc cctagcctgc     1200

ctctctaggt ttttcaatac atttcttgaa tggctaccca aaagctgacc gtccagcccc     1260

tgaccacact tgttcctagt gcagggagct cagacagggc cttccatcta gagcccagca     1320

cctagagcca ggctgcccag attcaaatcc tgactccgcc acttttccca ctgtatgatc     1380

ttgggcaagt cacttcacct ctctgtgcct tggtttcctc atttataaaa tgtggataac     1440

aggccgggcg cagtggctca cacctgtaat cccagcactt tgggaggccg aggcaggtgg     1500

atcacaagat caggagattg agaccatcct ggctaacatg gtgaaacccc atctctacta     1560

aaaatacaaa aaattagccg ggtgtggtgg tgggcacctg cagtcccagc tacttgggag     1620

gctgaggcag gagaatggcg tgaaactggg aggcagagct tgcagtgagc cgagatagcg     1680

ccactgcact ccagcctggg caacagagcg agactccgtc tcaaaaataa atataattaa     1740

ttaattattt aattaaaaaa ataaaaaata aatgtggata atactagtac ctccctctta     1800

aggtcagggc tggagctagg gtgacatctc cagggcagaa ttttaagagg acaccaaaaa     1860

agctcagcaa ccaagataaa aaatatttta aagcaatatt ttgttttggg tttttttttt     1920

ttgagatcaa gtatcactcg ttacccaggc tggaatgtag aggcgagatc tcagctcact     1980

gaaacctgtg cctccccggt tcaagcgatt ctcctgccac agcctcctga gtagctggga     2040

ttacaggcat gcgccaccat gcccagctaa tttttctatt tttagtagag acatgatttc     2100

accatgttgg ccaggctggt ctcgaactcc tgactcaaat gatccccctg cctcagcctc     2160

ccaaagtgct gggactacag gcatgagcca ctgtgcctga ccttacagca gtatttttta     2220

aaaatcaaaa ttaatgcaaa aatccatgat gaggccaggc ttggtggctc atgcctgtaa     2280

ttccagcact ttgggaggat cccttgagcc caggtgtttg agaccagttt gggtaacata     2340

ggaagagctt gtctctacaa acaaaaattt aaaaacaatg agctgggcat ggaactcaca     2400

cctctagccc cagctactca ggctgaagtg ggaggatggc ttgagcccag gagttcaagg     2460

atgcagtgtg ctttgattgc actactgcac ttcaccctaa gcaacagagt gagaccccat     2520

ctctttaaaa aaaaaaaaaa atccatgatg aacaaaacaa gtatttgttt gagacggggt     2580

ctcgctctgt cgcccaggct ggagtacagt ggtgccatct cagctcactg caacctccgc     2640

cttctgggtt caagcgactc tcctgcctca gcctcccgag tagctgggat tacaggagcc     2700

tggcactatg cctggctaat ttttgtattt ttattggaga caccatgtta gtcgtggctg     2760

gtctccaact cctgacctcg ggtgatccgc gccccgcggc ctccgaaagt gctgggatta     2820

caagcgtgag ccaccgtgcc cggcctaaat aaaattttga agaggctaga accccgcact     2880

tgtgccttga gcttactgac ctcaacaccc tggttccact aaaactttat ttacaaaatt     2940

atgctgccgg tctgcaggat gtagtttaac aatttgatta ttttggatat taaaatattt     3000

tttaagtctt gaaaatattg tttactatta ccaaagtttt tgaaccttct taaattctgt     3060

accagaggtg agtgccacac cctaacctag tctgagtttt tatgtgtaaa gatcataaaa     3120

cgttgtaagt tttctaaaac acataagctc tcaataaacg ttagcttatc attgtca        3177


<210> 163
<211> 4051
<212> DNA
<213> Homo sapiens

<400> 163
cgagcgcaag gacagcgcga ggtccgcgca gcccagcgca gccatggagc cccgcgcgga       60

ctcactctat gatgtccctg tcggtgcggc cgcagcgccg tctgctcagc gcccgggtca      120

ataggagcca gtccttcgca ggcgtcctcg gcagccacga gcgggggccc aggagtttcc      180

cggtcttcag cccgccgggg cccccacgga agccccccgc gctctcccga gtgtccagga      240

tgttttccgt ggctcaccca gccgccaagg tgccgcagcc cgagcggctg gacctggtgt      300

acacggcgct gaagcggggc ctgacggcct acttggaagt gcaccagcag gagcaagaga      360

aactccaggg gcagataagg gagtccaaga ggaattcccg cttgggcttc ctgtatgatc      420

tggacaagca agtcaagtcc attgaacgct tcctgcgacg actggagttc catgccagca      480

agatcgatga gctgtatgag gcatactgtg tccagcggcg tctccgggat ggtgcctaca      540

acatggtccg tgcctacacc actgggtccc cgggaagccg agaggcccgg gacagcctgg      600

cagaggccac tcgggggcat cgcgagtaca cggagagcat gtgtctgctg gagagcgagc      660

tggaggcaca gctgggcgag tttcatctcc gaatgaaagg gctggctggc ttcgccaggc      720

tgtgtgtagg cgatcagtat gagatctgca tgaaatatgg gcgtcagcgc tggaaactac      780

ggggccgaat tgagggtagt ggaaagcagg tgtgggacag tgaagaaacc atctttctcc      840

ctctactcac ggaatttctg tctattaagg tgacagaact gaagggcctg gccaaccatg      900

tggttgtggg cagtgtctcc tgtgagacca aggacctgtt tgccgccctg ccccaggttg      960

tggctgtgga tatcaatgac cttggtacca tcaagctcag cctggaagtc acatggagcc     1020

ccttcgacaa ggatgaccag ccctcagctg cttcttctgt caacaaggcc tccacagtca     1080

ccaagcgctt ctccacctat agccagagcc caccggacac accctcactt cgggaacagg     1140

ctttctataa catgctgcga cggcaggagg agctggagaa tgggacagca tggtccctgt     1200

catctgaatc ttcagacgac tcatccagcc cacagctctc aggcactgcc cgccactcac     1260

cagcccctag gcccctggtg cagcagcccg agccccttcc catccaagtt gccttccgca     1320

ggcctgagac ccccagctct gggcccttgg atgaggaggg ggccgtggcc ccagtcctgg     1380

caaatgggca tgcaccctac agtcggactc tgagccacat cagtgaggct agtgtagatg     1440

ctgccttggc tgaggcttca gtggaggccg ttggcccaga aagcctagcc tggggaccta     1500

gcccacctac acacccagct cccacccatg gagagcaccc cagtcctgtt cctcctgccc     1560

tggaccctgg ccactctgcc acaagctcta ccctcggtac aacaggctct gtccccacat     1620

ctacagaccc tgccccatct gcacacctag actcagttca taagtccaca gactctggcc     1680

cttcagaact gccaggcccc actcacacca ctacaggctc tacctatagt gccattacca     1740

ctacccacag tgctccaagc cccctcactc acactactac aggctccacc cacaagccca     1800

taatctctac ccttactact acaggcccta ccctcaatat cataggccca gtccagacta     1860

ccacaagccc cacccacact atgccaagcc ctacccatac cacagcaagc cccactcata     1920

cttccacaag ccccacccat acccccacaa gtcccaccca caaaaccagt atgtcacctc     1980

ccaccactac aagtcctacc cccagtggta tgggcctagt ccagactgcc acaagtccca     2040

cccatcctac cacaagcccc acccatccca ccacaagccc catccttata aatgtaagcc     2100

cttccacttc tctagaactt gctaccctct ccagcccctc caaacactca gaccccaccc     2160

tcccaggcac tgactccctt ccctgtagtc ccccagtctc caattcctac actcaggcag     2220

accctatggc ccccagaact ccccacccaa gtcctgccca ttccagtagg aaacccctca     2280

caagccctgc cccagatccc tcagagtcta cggttcagag tctaagcccc actccctcac     2340

ccccaacccc tgcaccccag cattcagacc tttgcctggc catggctgtc cagaccccag     2400

tcccaacggc agccggaggg tctggggaca ggagcctgga ggaggcactg ggggccctaa     2460

tggctgccct ggatgactac cgtggccagt ttcctgagct gcagggcctg gagcaggagg     2520

tgacccgcct agaaagtctg ctcatgcaga gacaaggtct gactcgcagc cgggcctcca     2580

gtctcagcat cactgtggag catgccttgg agagcttcag cttcctcaat gaagacgaag     2640

atgaagacaa tgatgttcct ggggacaggc ctccaagcag cccggaggct ggggctgagg     2700

acagcataga ctcacccagt gcccgccccc tcagcacggg gtgtccagct ctggatgctg     2760

ccttggtccg gcacctgtac cactgcagtc gcctcctgct gaaactgggc acatttgggc     2820

ccctgcgctg ccaggaggca tgggccctgg agcggctgct gcgggaagcc cgagtactgg     2880

aggcagtatg cgagttcagc aggcggtggg agatcccggc cagctctgcc caggaagtgg     2940

tgcagttctc ggcctctcgg cctggcttcc tgaccttctg ggaccagtgc acagagagac     3000

tcagctgctt cctctgcccg gtggagcggg tgcttctcac cttctgcaac cagtatggtg     3060

cccgcctctc cctgcgccag ccaggcttgg ctgaggctgt gtgtgtgaag ttcctggagg     3120

atgccctggg gcagaagctg cccagaaggc cccagccagg gcctggagag cagctcacag     3180

tcttccagtt ctggagtttt gtggaaacct tggacagccc caccatggag gcctacgtga     3240

ctgagaccgc tgaggaggtg ctactggtgc ggaatctgaa ctcggatgat caggctgttg     3300

tgctgaaggc cctgagattg gcgcccgagg ggcgtctgcg aagggacggg ctgcgggccc     3360

tcagctccct gctcgtccat ggcaacaaca aggtcatggc tgctgtcagc acccagctcc     3420

ggagcctgtc actgggccct accttccggg agagggccct cctgtgcttc ctggaccagc     3480

tggaggatga ggacgtgcag actcgagtgg ctggctgcct ggccctaggc tgcatcaagg     3540

ctcccgaggg cattgagccc ctggtgtacc tctgccaaac tgacacagaa gctgtgaggg     3600

aagctgcccg gcaaagccta cagcagtgtg gagaagaggg acagtctgcc catcgacggc     3660

tggaggagtc cctggacgcc ctgccccgca tctttgggcc tggcagcatg gccagcacag     3720

cattctaaac tattcaccca tgggttcctg gtgccccttt ccccccactt tcagggctca     3780

ccaggcactg gcagggaggg taagggctgg ctccagatac ccctccccca cagattccta     3840

gcaatgaaaa tctaatatat tcttctgttg cccctggggt tggagagtca gtgcctgcag     3900

tcaagtgcct cccagcctcg gctcagcaca tcccttgcca caaatcagtg tctggggctt     3960

ggccaccctg ccgctgccca gccacatccc ttggttttgt attttattta cagagtttta     4020

cagaaaataa aaaagcaaaa tgtctttcct a                                    4051


<210> 164
<211> 2048
<212> DNA
<213> Homo sapiens

<400> 164
cagactgcca taagatggcg tccgtggcgg ctgcacgagc agttcccgtg ggcagtgggc       60

tcaggggcct gcaacggacc ctacctcttg tagtgattct cggggccacg ggcaccggca      120

aatccacgct ggcgttgcag ctaggccagc ggctcggcgg tgagatcgtc agcgctgact      180

ccatgcaggt ctatgaaggc ctagacatca tcaccaacaa ggtttctgcc caagagcaga      240

gaatctgccg gcaccacatg atcagctttg tggatcctct tgtgaccaat tacacagtgg      300

tggacttcag aaatagagca actgctctga ttgaagatat atttgcccga gacaaaattc      360

ctattgttgt gggaggaacc aattattaca ttgaatctct gctctggaaa gttcttgtca      420

ataccaagcc ccaggagatg ggcactgaga aagtgattga ccgaaaagtg gagcttgaaa      480

aggaggatgg tcttgtactt cacaaacgcc taagccaggt ggacccagaa atggctgcca      540

agctgcatcc acatgacaaa cgcaaagtgg ccaggagctt gcaagttttt gaagaaacag      600

gaatctctca tagtgaattt ctccatcgtc aacatacgga agaaggtggt ggtccccttg      660

gaggtcctct gaagttctct aacccttgca tcctttggct tcatgctgac caggcagttc      720

tagatgagcg cttggataag agggtggatg acatgcttgc tgctgggctc ttggaggaac      780

taagagattt tcacagacgc tataatcaga agaatgtttc ggaaaatagc caggactatc      840

aacatggtat cttccaatca attggcttca aggaatttca cgagtacctg atcactgagg      900

gaaaatgcac actggagact agtaaccagc ttctaaagaa aggacctggt cccattgtcc      960

cccctgtcta tggcttagag gtatctgatg tctcgaagtg ggaagagtct gttcttgaac     1020

ctgctcttga aatcgtgcaa agtttcatcc agggccacaa gcctacagcc actccaataa     1080

agatgccata caatgaagct gagaacaaga gaagttatca cctgtgtgac ctctgtgatc     1140

gaatcatcat tggggatcgc gaatgggcag cgcacataaa atccaaatcc cacttgaacc     1200

aactgaagaa aagaagaaga ttggactcag atgctgtcaa caccatagaa agtcagagtg     1260

tttccccaga ccataacaaa gaacctaaag agaagggatc cccagggcag aatgatcaag     1320

agctgaaatg cagcgtttaa gagacatgtc cagtggcctt tggaaaggtg gtggggatcc     1380

agttcaggag ggaggggtat gtttgtctcc cagtctgggc aaaggagtgc tatgcggaat     1440

tctctgcata gcagaaaagc tcccaccatt ttcttttgat gtggttttaa agtctcacgt     1500

tctctataat agaaacagca ggtcttgtca gctccttgtg tggctgatgt gtctggaaat     1560

gatgtagttc aggaaagcat tttttttttc tttgaacctt aaaggttcta ttattaaaag     1620

cagcacagat tccacatttt tatacatgag gatcttcttt gtggtgaata ccaggattga     1680

ctgcatccct ttaaagaagt tttatgtccc tgactctggc taaaattatc taatttccag     1740

atgcttttgt agatgactga agtatttgtg agccacatat tgggagttct agatttgagt     1800

gaatggcagg aaagggccat ctccattgag atgattaagt gaaccaaact agttctcaga     1860

attctacaga gaaggaggga atcagactga ggaagctgtg acataggact tgaagaccaa     1920

agactttgaa atttgcgagc tgctcatgtg tgagttatta tcactgctgt ctttctattg     1980

agttacaaat ctatattttt attgaagttt aaataaagaa aaaatttaca agagcctctt     2040

tgatcctt                                                              2048


<210> 165
<211> 990
<212> DNA
<213> Homo sapiens

<400> 165
ggctccctgt cgccgcggag gggcgggggc aggacgcgca actccggccg gagctgtccg       60

gggtcgtgag ccggccccgc cttggtggcg gcgccccctc gcggtccaga ggcagacgca      120

tcgggtgggc tcgggtctcc agcccggccg ggaggaggga ccgggtctgc ggagcgggga      180

ctcggggcct cggcggggcg cgcacacgca ggcggggcgg cccggggtgc ggggcctctg      240

cgcggctgac caggctccca gagcgtcagc gccgcccatg gccgagccgc tccagccaga      300

ccccggggcg gccgaggacg cggcggccca agctgtggag acgccgggct ggaaggcccc      360

ggaggacgcc ggcccccagc ccggaagtta tgagatccga cactatggac cagccaagtg      420

ggtcagcacg tccgtggagt ctatggactg ggattcagcc atccagacgg gctttacgaa      480

actgaacagc tacattcaag gcaaaaacga gaaagagatg aaaataaaga tgacagctcc      540

agtgacaagc tacgtggagc ctggttcagg tccttttagt gagtctacca ttaccatttc      600

cctgtatatt ccctctgaac agcaatttga tccacccagg cctttagagt cagatgtctt      660

cattgaagat agagccgaaa tgactgtgtt tgtacggtct ttcgatggat tttctagtgc      720

ccaaaagaat caagaacaac ttttgacatt agcaagcatt ttaagggaag atggaaaagt      780

tttcgatgag aaggtttact acactgcagg ctacaacagt cctgtcaaat tgcttaatag      840

aaataatgaa gtgtggttga ttcaaaaaaa tgaacccacc aaagaaaacg aatgagaaaa      900

atgaaaggaa gttctgctgt cagaggcaaa acatctgttt atcatagaca tcaacatgac      960

ctataagtaa agtgcgtgtc tagtgtcttc                                       990


<210> 166
<211> 2190
<212> DNA
<213> Homo sapiens

<400> 166
gacagactcc cagaagatct gagcgagtcg cgtagctgag cccggcaggg gctggggtgg       60

tgctgctgct atgagctgca ccatcgagaa gatcctgaca gacgccaaga cgctgctgga      120

gaggctacgg gagcacgatg cggccgccga gtcgctggtg gatcagtcgg cggcgctgca      180

ccggcgggta gcagctatgc gggaggcggg gacagcgctt ccggaccagt atcaagagga      240

tgcatccgat atgaaggaca tgtccaaata caaacctcac attctgctgt cccaagagaa      300

cacacagatt agagacttgc aacaggaaaa cagagagcta tggatttcct tggaggaaca      360

ccaggatgct ttggaactta tcatgagcaa atatcggaaa cagatgttac agttaatggt      420

tgctaaaaaa gcggtggatg ctgaaccagt cctgaaagct caccagtctc actctgcaga      480

aattgagagt cagattgaca gaatctgtga aatgggagaa gtgatgagga aagcagttca      540

ggtggatgat gaccagtttt gtaagattca ggaaaaatta gcccaattag agcttgaaaa      600

taaggaactt cgagaattat tgtccatcag cagtgagtct cttcaagcca gaaaggaaaa      660

ctcaatggac actgcttccc aagccatcaa ataactgaac tctgaatgat ggctggagat      720

tgtctatcaa ggaaggaagt tactgtcttc ccattcaagt actgtccatt aagtgtcttg      780

cctcagattt gatttaatct taattaaagg tatcaggtgg caatttagaa ttccagtcaa      840

tattggctgt ccacagttct cagatgtgtt aatgtgaata ctacatgctg aatttcacca      900

ttcctttctc aaagagacta cttttaattt tcatttctgg gaccttgatt tatataaact      960

atgttttcag ttctttgtta tttttcacat ctctgaaact ttgagcattt tttataagcc     1020

agcaatttat tttacatagc attgtaaaat acacttctag gaaattttag gaaagattta     1080

actgtttaaa tctatttggc ataaaccttg attttttttt tccatttgac aaaaataata     1140

caattccaca gaactagatc agcagattct ctgatttgta atgtcattca cctgtgacat     1200

tttaagtctc tctggtgcta agaattggca ctttatagcc tggtgccttt acttttaatt     1260

tgagagaacc tactgctagt cccaggaaac acacttggaa ataagtcagc tatttttttt     1320

gcccagtgat gctatagttg tcatattgtc caaagttcat attgttcaaa gctgaggagc     1380

ttgtcctgtg tatgtgaatg cacacatgtg cacttagttc aaatactaaa agtagctttt     1440

attaaatata atcagccaaa aacacacaca aaataaaaaa aacaaatata agtagtcagt     1500

ttttcaatgt tatcctacta gttctacatt ctattttaat ttttatacaa tttccatttt     1560

atagttaaga accatcactt acttggattg gatgtctttc attcctagca ctaatagttg     1620

gctttctttt tttttgttta catagaagca gggttttttt ttatcttttt tctttttttt     1680

tgtttaagct atataaaaag gtgaggaagc agttttgtta cctaatgaaa attattacac     1740

tcataatgct gtgtaggcaa cattgagatt caaatgccca gtggtcaact gggttcactc     1800

atcaactcat tcccgtccca gtttactcac atttcaaatt tataaatttc ttcatgttat     1860

actattctat ttagatttgc ccagaattag ttgaaataat gctaaacctg tcaatatttt     1920

ccagtaacat taagcaccat actgcatggg agagacacag tactaaaaag agttgttagt     1980

gctttatgtg agtgatattt ctttcgtaat gctataaaga actacagtta aaataacaaa     2040

atattttaaa gatgtcctaa aagcatctga tcccagtaat aactaatgga tgtcatctag     2100

agcagtgggt gttaatgaat aggtatatgt catttaagaa tttttcaaat ttctgtttga     2160

tatcctgcat agaatttgac aaaaaaaaca                                      2190


<210> 167
<211> 4391
<212> DNA
<213> Homo sapiens

<400> 167
ggggggggcg gaggctccgt ggaaatgtgt cggtgacatt gaatggggag accgagcgcg       60

agcgaggcgc gcgcgcgcac acgcgcactc acggccccgc tcgctccgag atccccggcc      120

acgtaagtaa ctattaatac cgcctcgccg ggggatgcgg gcgtgctgag cgcggggatt      180

ggcctcgggc accgtcggcc gtccccttta atttttaaat acacggtccc ctcttttctc      240

tggggggggc aagcaagaaa tcaaagaagg aggagacaag ccgtcaattt tctccaaaac      300

aaaccccacc gggcaatttg gtctcggggt agggggagac ggggtgattg caaattattc      360

caggacgaga tccagttctc cagcgggaaa ggggcaaagg aacgccgcgc gttggaaggg      420

ccagggacgc agctcccctt gcagcgcccg caggaccccc gcaagctcgt gccggcgaaa      480

tcggagaccg ccgatctgtc ctcgttctct cctgcacgtc tggctgcatt cggaggaaga      540

cctggggcgc gagcgagcgg cgacagcatg agcctgtgct gacctccgcg cggcgggccg      600

agcccagggc tttgtcgcgg tacctgcgcc cagcccgcgc cgcaactctg tgcccagctt      660

ttgcaatctt ttgttggcag cgctgaccgc accaagttaa atgctccctt gcaatttttc      720

ttttttttgt ttgtttgttt aatttttgga gagctcgcga tcttggaaaa gcctcagacg      780

ccatctacag ttaaaacgta ggtaactgcc ctctcccgca cccccccctt acacgccccc      840

caccctttcc accaaaaaaa gggggtgcag cgcggattct ggctgccgtg cgtcgccagc      900

cggtagaccc gtgcttgttt cctttctctt tttgtttggc ttctaacgcg ttgggactga      960

gtcgccgccg tgagctcccc gaagactgca caaactaccg cgggctcctc cgccccgtct     1020

gcgattcgga agccggcctg ggggtcgcgt cgggagccct ggcgctgcag ctccgcacct     1080

tagcagcccg ggtactcatc cagatccacg ccggggacac acacacagag taactaaaag     1140

tgcggcgatt ctgcacatcg ccgactgctt tggggtaaca aaaagacccg agttgcctgc     1200

cgaccgagga cccccgggag ccgggctcgg agcagacgag gtatccggcg gcgcccattt     1260

gggggcttct aactctttct ccacgcagcc cctcttctgt cccctcccct ctcgctccct     1320

tttaaaatca gtggcaccga ggcgcctgca gccgcactcg ccagcgactc atctctccag     1380

cgggtttttt tttgtttgtc gtgtgcgatc ctcacactca tgaacataca caggtctacc     1440

cccatcacaa tagcgagata tgggagatcg cggaacaaaa cccaggattt cgaagagttg     1500

tcgtctataa ggtccgcgga gcccagccag agtttcagcc cgaacctcgg ctccccgagc     1560

ccgcccgaga ctccgaactt gtcgcattgc gtttcttgta tcgggaaata cttattgttg     1620

gaacctctgg agggagacca cgtttttcgt gccgtgcatc tgcacagcgg agaggagctg     1680

gtgtgcaagg tgtttgatat cagctgctac caggaatccc tggcaccgtg cttttgcctg     1740

tctgctcata gtaacatcaa ccaaatcact gaaattatcc tgggtgagac caaagcctat     1800

gtgttctttg agcgaagcta tggggacatg cattccttcg tccgcacctg caagaagctg     1860

agagaggagg aggcagccag actgttctac cagattgcct cggcagtggc ccactgccat     1920

gacggggggc tggtgctgcg ggacctcaag ctgcggaaat tcatctttaa ggacgaagag     1980

aggactcggg tcaagctgga aagcctggaa gacgcctaca ttctgcgggg agatgatgat     2040

tccctctccg acaagcatgg ctgcccggct tacgtaagcc cagagatctt gaacaccagt     2100

ggcagctact cgggcaaagc agccgacgtg tggagcctgg gggtgatgct gtacaccatg     2160

ttggtggggc ggtacccttt ccatgacatt gaacccagct ccctcttcag caagatccgg     2220

cgtggccagt tcaacattcc agagactctg tcgcccaagg ccaagtgcct catccgaagc     2280

attctgcgtc gggagccctc agagcggctg acctcgcagg aaattctgga ccatccttgg     2340

ttttctacag attttagcgt ctcgaattca gcatatggtg ctaaggaagt gtctgaccag     2400

ctggtgccgg acgtcaacat ggaagagaac ttggaccctt tctttaactg agctcatgcc     2460

ccacggagac ttagcaggtt ccaggagtga gcgagggcag cggaaaggag ttcttccggg     2520

ggacacgaat tgcctggctg agtagcaaga aagacacact cttaagtttc ttggttcaga     2580

gcaggaaaac cttcaaggag ctgactgacc acgtagcatg ggggcaagag gcgtgggatg     2640

gggattgggg tgagatggat gggagcccgc tggagcttgt cttccctaac atagcctggg     2700

agaccacccc ttgccacttg ggccacttcc gcctacccca cttttcattt tgttccaaaa     2760

tagttgcaga tcctgacaga atcaaaactc tctgcctcaa acacacatcc tggcatcgca     2820

ctgttagcat ttaacttctt gttaggattc agggaaggaa cagttggcca agaatttttt     2880

ttcttttaaa caagccaacc acctagctgg taattaatga ggttcactta aaaaaaaaat     2940

tcggtgcaca cagactgaca tgaaacctgg gtgctacagt aaaagaaaac aaaagtccag     3000

tttgtgtctc ttaatcgctc acttcaactc atttcttcta aataaactat ttaatatcct     3060

ggtcaggaaa tgacatgtta atgctttgct ccctgaaggg ggaaaaaatc tgtcctttaa     3120

caagctattc tgttttgtgt caattggttc gtggcaggaa gctattagaa gtcaaacgtc     3180

cagatgcatt actgctatct tagtttaaag ggggaaagaa aagggaagaa gaaaggaaaa     3240

gagaaatcca actccttttt catgttttgc ttttgaacaa tgagggtttg tgtgacaggc     3300

attcctcttt gctgagatga tagcaatggc ctgagatttt agcaagctcc tggagtctga     3360

tgcttttgca gtactctgat cgcaactaaa catttgtctt tgttttatta gaaactagtg     3420

aaacaaagca ggttgtccca catgtataaa atacagggca gctatttagt tttctttaca     3480

gagaatgatc cttttaaggc ttgtaaggcc ctctggtttg gacaaaaacc ctcagtagag     3540

acaagcggga aggataatta gctgaaagct atgatgatat aaataaaaac agctctctat     3600

cccaatacgc acctttgtat tttcaagaac tcttctattt attaaggaaa atgtcacatt     3660

gtgatgtatt aagccagtac ttcaattacg ggttgacttg ggatgacata ttacatgctg     3720

tagttaacat ttataattct ttttccttgt ttgagtattt ctgtctctga aataaccttt     3780

tacttggctt ttctagatag ctttatttga tttcgagtgg caaaatgttt tttattacgg     3840

cttttctatt gctgtatgat acagaactct tttggcataa atatttgtgt tcccagtacc     3900

tcacttgttc ggatttgact gcctgtatat gttttgtgaa atggtcctgt ttttgggtag     3960

gtgacacgtg gactctagta tgtaaatgtt acttgaatct gtgcttcata atagtgtgtg     4020

gcatgtatgt gcagactctt ggatgcttta tgcctgcgca gcaggagccc tgtcctcacg     4080

ttcccaggag ggcggcttca cccttcgtaa ccaggagaca aggcggccat ggatttgccc     4140

ttgattctat tttgctaatg gaagatagaa aggagagaag gttttttttt tttttaacat     4200

tctgaagatg gtgctgtgtc aagaaggacc ttttttttcc cctctcccct attttttaag     4260

taccttggag gaggagaggt tggtgacatg catggtgggg atctatggcc tctggtgctt     4320

tgtcctgtat ttggtttaat gtttttgtcc taatctcttc aatcaataaa attgtgcgta     4380

tttaactaaa a                                                          4391


<210> 168
<211> 3504
<212> DNA
<213> Homo sapiens

<400> 168
ggaggtgagc aggaaggaga cggccgccca gcagcccgtg ggcaggcgcg gcggagcgag       60

cggggccggc ggcgggcgcc gagggacgcc gaggcctcgg gcgggggctg gcccggggtt      120

ccaggtctcc agtgggggct gcagactaag caaaatgagg cggttcctga ggccagggca      180

tgaccctgtg cgggagaggc tcaagcggga cctgttccag tttaacaaga cggtggagca      240

tggcttcccg caccagccca gcgccctcgg ctacagcccg tccctgcgca tcctggccat      300

cggcacccgt tctggagcca tcaagctcta cggagcccca ggcgtggagt tcatggggct      360

gcaccaggag aacaacgctg tgacgcagat ccacctcctg cccggccagt gccagctggt      420

caccctgctg gatgacaaca gcctgcacct ttggagcctg aaggtcaagg gcggggcatc      480

ggagctgcag gaggatgaga gcttcacact gcgtggaccc ccaggggctg cccccagtgc      540

cacacagatc accgtggtcc tgccacattc ctcctgcgag ctgctctacc tgggcaccga      600

gagtggcaac gtgtttgtgg tgcagctgcc agcttttcgt gcgctggagg accggaccat      660

cagctcggac gcggtgctgc agcggttgcc agaggaggcc cgccaccggc gtgtgttcga      720

gatggtggag gcactgcagg agcaccctcg agaccccaac cagatcctga tcggctacag      780

ccgaggcctc gttgtcatct gggacctaca gggcagccgc gtgctctacc acttcctcag      840

cagccagcaa ctggagaaca tctggtggca gcgggacggc cgcctgctcg tcagctgtca      900

ctctgacggc agctactgcc agtggcccgt gtccagcgaa gcccagcaac cagagcccct      960

ccgcagcctc gtgccttacg gtccctttcc ttgcaaagcg attaccagaa tcctctggct     1020

gaccactagg caggggttgc ccttcaccat cttccagggt ggcatgccac gggccagcta     1080

cggggaccgc cactgcatct cagtgatcca cgatggccag cagacggcct tcgacttcac     1140

ctcccgtgtc atcggcttca ctgtcctcac agaggcagac cctgcagcca cctttgacga     1200

cccctatgcc ctggtggtgc tggctgagga ggagctggtg gtgattgacc tgcagacagc     1260

aggctggcca ccggtccagc tgccctacct ggcttctctg cactgttccg ccatcacctg     1320

ctctcaccac gtctccaaca tcccgctgaa gctgtgggag cggatcattg ccgccggcag     1380

ccggcagaac gcacacttct ccaccatgga gtggccaatt gatggtggca ccagcctgac     1440

cccagcccca ccccagaggg acctgctgct cacagggcac gaggacggca cggtgcggtt     1500

ctgggatgcc tcgggtgtct gcctgcggct gctctacaaa ctcagcactg tgcgcgtgtt     1560

cctcaccgac acggacccca acgagaactt cagtgcccag ggcgaggacg agtggccccc     1620

actccgcaag gtgggctcct ttgaccccta cagtgatgac ccccggctgg gcatccagaa     1680

gatcttcctc tgcaagtaca gcggctacct ggctgtggca ggcacggcag ggcaggtgct     1740

ggtactggaa ctgaatgacg aggcagcgga gcaggctgtg gagcaggtgg aggccgacct     1800

gctgcaggac caagagggct accgctggaa ggggcacgag cgcctggcag cccgctcagg     1860

gcccgtgcgc tttgagcctg gctttcagcc cttcgtgttg gtgcagtgtc agcccccggc     1920

tgtggtcacc tccttggccc tgcactctga gtggcggctc gtggccttcg gcaccagcca     1980

tggctttggc ctctttgacc accagcagcg gcggcaggtc tttgttaagt gcacactgca     2040

ccccagtgac cagctggcct tggagggccc actctcccgc gtcaagtccc tcaagaagtc     2100

cttgcgtcag tcattccgcc ggatgcgtcg gagccgggtg tccagccgga agcggcaccc     2160

ggctggcccc ccaggagagg cacaggaggg gagtgccaag gctgagcggc caggcctcca     2220

gaacatggag ctggcgcctg tgcagcgcaa gatcgaggct cgctcggcag aggactcctt     2280

cacaggcttc gtccggaccc tgtactttgc tgacacctac ctgaaggaca gctcccggca     2340

ctgcccctcg ctgtgggctg gcaccaatgg gggcaccatc tatgccttct ccctgcgtgt     2400

gcctcccgcc gagcggagaa tggatgagcc tgtgcgggca gagcaggcca aggagatcca     2460

gctgatgcac cgggcgccgg tggtgggcat cctggtgctc gacggacaca gcgtacccct     2520

tcccgagccc ctcgaagtgg cccatgatct gtcgaagagc cctgacatgc agggaagcca     2580

ccagctgctc gtcgtatcag aggagcagtt caaggtgttc acgctgccca aggtgagtgc     2640

caagctgaag ttgaagctga cggccctgga gggctcaaga gtgcggcggg tcagcgtggc     2700

ccacttcggc agtcgtcgag ccgaggacta cggggagcac cacctggcag tccttaccaa     2760

cctgggcgac atccaggtgg tctcgctgcc cctgctcaag ccccaggtgc gctacagctg     2820

catccgccgg gaggacgtca gtggcatcgc ctcctgcgtc ttcaccaaat atggccaagg     2880

cttctacctg atctcaccct cggagtttga gcgcttctct ctctccacca agtggctggt     2940

ggagccccgg tgtctggtgg attcagcaga aaccaagaac caccgccctg gtaacggtgc     3000

gggccccaag aaggccccga gccgagccag gaactcaggg actcagagtg atggcgagga     3060

gaagcagccc ggcctggtga tggagcgcgc tctgctcagt gatgagagag cggcaactgg     3120

cgttcacatc gagccgccgt ggggtgcagc ctcagcaatg gcggagcaga gtgagtggct     3180

gagcgtccag gctgcgcgat gagcacacac tactactgat ggcctttcgg gggtccctgc     3240

cccaaccgga gaggccggtg cacagggccc cgccaggggc tgggggcatc ccggcttcca     3300

caatgcagct gctctgggcc tcgggagagg agagacccca gtcccctggg ctgcccttcc     3360

cgggcctcgt ctgtctgggt cctttggtca atgttgcaca gtttttattg ctcccatccc     3420

tttttgtagt gggctgggtt ttaagttata aatgttaact gcctctgggt gaaaaagttt     3480

ttaataaaca cctattacct cttg                                            3504


<210> 169
<211> 1940
<212> DNA
<213> Homo sapiens

<400> 169
agacgctcgg gggaacatgg cggctgcgga gccggcggtc cttgcgctcc ccaacagcgg       60

cgccgggggc gcgggggcgc cgtcgggcac agtcccggtg ctcttctgtt tctcagtctt      120

cgcgcgaccc tcgtcggtgc cacacggggc gggctacgag ctgctcatcc agaagttcct      180

cagcctgtac ggcgaccaga tcgacatgca ccgcaaattc gtggtgcagc tgttcgccga      240

ggagtggggc cagtacgtgg acttgcccaa gggcttcgcg gtgagcgagc gctgcaaggt      300

gcgcctcgtg ccgttgcaga tccagctcac taccctggga aatcttacac cttcaagcac      360

tgtgtttttc tgctgtgata tgcaggaaag gttcagacca gccatcaagt attttgggga      420

tattattagc gtgggacaga gattgttgca aggggcccgg attttaggaa ttcctgttat      480

tgtaacagaa caatacccta aaggtcttgg gagcacggtt caagaaattg atttaacagg      540

tgtaaaactg gtacttccaa agaccaagtt ttcaatggta ttaccagaag tagaagcggc      600

attagcagag attcccggag tcaggagtgt tgtattattt ggagtagaaa ctcatgtgtg      660

catccaacaa actgccctgg agctagttgg ccgaggagtc gaggttcaca ttgttgctga      720

tgccacctca tcaagaagca tgatggacag gatgtttgcc ctcgagcgtc tcgctcgaac      780

cgggatcata gtgaccacga gtgaggctgt tctgcttcag ctggtagctg ataaggacca      840

tccaaaattc aaggaaattc agaatctaat taaggcgagt gctccagagt cgggtctgct      900

ttccaaagta taggacattt gaagaactgg tatgctactc actggtgaag gacagtcagg      960

tgaaggactg taagcccaca caagctcttc ttatctctac tagaattaaa atgttaagtc     1020

aaaaacggct ccttttttgc gcctcctagt gaaacttaac cagctagacc atttgagtac     1080

cagcatttag ttacaaacgt caaaggcttc cggtgctgct taccttcctt ttttgttaat     1140

gtgcttttat ttattaaaaa aaattacaat gaagatgcct gttttgtctc tactgtgtac     1200

tctgatcgta tctttccaaa gtgcagactc ttgtgaagtt ttcttaaatt gttcacttta     1260

aagaaaatga cgtaccaaca atgatttggc ttttatatta ctgtaagatg ttataatgtt     1320

aatgtggatg tagtgctttt actttacaga ttgattggaa taagattatt gcatatgaat     1380

ttacccacag gactctgaat catgttaccc actcccctca caatgttgtc cacttagtga     1440

gttgcattga tctatccgta ccaaatgatg ttgaataatt acatatcttt cttgactata     1500

ctgatttctt attttggtca ctattactaa atctctgtta atattctctc ttttaactga     1560

aaagggatgg gatagaaggg tttgcaatgc catattattg gtggagggct gttttaacat     1620

ctttgaagta tggcttgctg aatatcttta ccaacatctt gaatatatat tctagtgtcc     1680

acaagattta gcaaaaagat aaagcttggg tggaatatca ttttaaaatg ttcatgttct     1740

gttctatatt ttcttcacct actctccaaa tattgtaatg caaaaagtct cagtaatgat     1800

ttggtagtat taattttgtg gtcattgttt ctcttcgata aatttatttt cattaaatac     1860

ttgttagagg gttttgaaat gtttttcaaa tatgtgaaat gtgaaactgc tgtcttttat     1920

attaaagtaa ttaaagaaaa                                                 1940


<210> 170
<211> 3433
<212> DNA
<213> Homo sapiens

<400> 170
gtgctattag atttgcaaat tgctgatctc ccagtgactt tccctcttag atcccagttg       60

agtatggtta ccttgagaac tgtggtatta gccatgttag agcatgctcc actggggagt      120

tctgtgcagt ctatttttaa tgctatttaa tgaaggagcg agcgcctcac tcagcaataa      180

aagaagcatg agggaagaca gagcagtgca tggttatgga tactggacaa ggatatttgg      240

aaaggttgac gatgtgtcac actgtgtaag ggaatcgcat ggagatgggc attccgaact      300

gttaatgggg acatgggact ccagttgtct ctgatcactt gtgtggattt tcctggcgta      360

gaacgacaga agccgctagt aagtcgccaa gacctacagc aggaattctg caccaaaggg      420

cataaaatct tgttatttta atttgcatct gggagaatgt ctgagcaagg agacctgaat      480

caggcaatag cagaggaagg agggactgag caggagacgg ccactccaga gaacggcatt      540

gttaaatcag aaagtctgga tgaagaggag aaactggaac tgcagaggcg gctggaggct      600

cagaatcaag aaagaagaaa atccaagtca ggagcaggaa aaggtaaact gactcgcagc      660

cttgctgtct gtgaggaatc ttctgccaga ccaggaggtg aaagtcttca ggatcaggaa      720

tcaattcatt tacagctttc cagtttttcc agcctgcaag aggaggataa atctaggaaa      780

gatgactctg aaagagaaaa agaaaaggat aaaaacaaag ataaaacctc tgaaaaaccc      840

aagatcagaa tgttatcaaa agattgcagc caagaataca cggattctac aggcatagac      900

ttacacgagt ttctgattaa cacattaaag aataattcca gggacaggat gatacttttg      960

aaaatggagc aggaaattat tgatttcatt gctgacaaca ataatcatta taaaaagttc     1020

cctcagatgt catcgtatca gaggatgctt gtccatcgag tggcagctta ttttggattg     1080

gatcacaatg tggatcaaac aggaaaatct gttatcatca acaagaccag cagcaccaga     1140

ataccagagc aaaggttttg tgaacattta aaagatgaaa aaggtgaaga atcccagaag     1200

cggtttatct tgaagcgaga taactctagt attgataaag aagacaatca gcaaaacaga     1260

atgcatccat ttagagatga cagacgaagt aaatcaattg aagagagaga agaggaatat     1320

cagagagtga gggagagaat atttgcacac gattcagttt gctcccagga aagccttttt     1380

gtggaaaaca gtaggctctt ggaagacagt aacatatgca atgagaccta taagaaaaga     1440

cagctctttc ggggcaacag agatggctca gggagaacat ctgggagtcg acagagcagc     1500

tcagaaaatg aactcaagtg gtctgaccac caaagggcct ggagcagcac agactccgac     1560

agttccaacc gcaatctaaa gcccgccatg accaagacgg cgagttttgg gggcatcacg     1620

gtgctgacca ggggtgacag cacttccagt actaggagta ccgggaagct gtccaaagca     1680

ggttccgagt cttccagcag tgcaggctcc tcaggatcgc tgtcccgcac ccatccacct     1740

ctccagagca cacccctagt ctcaggtgtg gcagctggct ctccaggctg tgtgccttat     1800

ccagagaatg gaataggggg ccaggttgct cccagcagca ccagctacat cctccttcca     1860

cttgaagctg caacaggcat cccgcctgga agcatccttc ttaatccaca cacaggccag     1920

ccctttgtga atcccgatgg aactcctgca atatacaacc cacccaccag tcagcagccc     1980

ctgcgaagcg ccatggtggg gcagtcccaa cagcagccac cacagcagca gccctccccg     2040

cagccccaac agcaggtcca gccaccgcag ccacagatgg caggccctct ggtcactcag     2100

agagatgatg tggcaacaca gtttggccag atgaccctga gccggcagtc ctcgggggag     2160

actcctgaac ccccatcagg tcctgtctac ccatcctccc ttatgccaca gccggcccag     2220

cagcccagct atgtaatcgc ctctacaggc cagcagcttc ctacaggagg attctcaggc     2280

tctggccctc ccatctccca gcaggtcctc cagccccctc cctcaccaca gggatttgtg     2340

caacagcctc cgcctgcaca gatgcctgta tattattacc catctggtca gtaccctacc     2400

tcaaccacgc aacagtaccg gcccatggcc ccggttcagt acaacgctca gaggagtcaa     2460

cagatgccac aggcagcaca gcaagcaggt taccagccag tcttgtctgg tcaacaggga     2520

ttccaaggcc taataggagt gcagcagcca cctcagagtc agaacgtgat aaataaccaa     2580

caaggaactc cggtgcaaag cgtgatggtt tcctacccaa caatgtcttc ttatcaggtg     2640

ccaatgaccc agggttctca aggactgccc cagcagtcat accaacagcc aatcatgcta     2700

cctaaccagg caggtcaagg gtcactccca gccactggaa tgcctgttta ctgtaatgtc     2760

acaccgccca cccctcagaa caaccttagg ctgattggcc cacactgccc ctccagcact     2820

gtcccagtga tgtcagctag ctgcagaaca aactgtgcaa gtatgagcaa tgctggttgg     2880

caggtcaaat tctgagagct ctggctgtgg tacatttctt cagatatttc tcatggcctt     2940

tgatggaaga ggaacaaggt gggaaaactg gctgaggact taagtattca ctcaacactc     3000

aaatgattgc tgctggtatt ctgtaaaaaa taaacaaaga ctaatataca cgttagctgg     3060

ttaatggtgc atatttctgt catgtctgct aggtatgcct ttatagctta gctagtgaca     3120

tgaattcatc aaggtaagat tttctcctac cactgaatac cactgtgtag attataatat     3180

ccctaatttg gattagtttt gtactttgtg ttgagtttgt gatgctaaaa gtatttaaaa     3240

attatatact aaatcacatt gtaccaaagc tgtaatggaa aagcaaagaa gaattgatga     3300

attgaaggaa taatttatat acattataga gttttctttt ttaatggata tatactgtat     3360

tgtagtgttt aatcaaaata aaactatttg accttatgga ggaaggtcat gtttttacca     3420

ccagtttggt tca                                                        3433


<210> 171
<211> 2464
<212> DNA
<213> Homo sapiens

<400> 171
ctcgctctgt cgcccaggct ggagtgtagt ggagccatct cggctcactg caacctccgc       60

ctccccggtt caagcaattc tcccgcctca gcctcccgag tacttgggat tacaggcgcc      120

cgccacctcg cccggctact ttttgtattt ttaatagaga cggggtttcg ccgtgttggt      180

caggctggtc tcaagctcct gacctcaagt gatctgcttg ccttggtctc ctaaagtgct      240

gggattacag gcgtgagcca ccgcgtccgg cccaaaagcc ttttttggat gagaaagact      300

cactcagctt cgtcctgaag agcaagtggg ctggggaaga ggagagtatg aatgtgagtc      360

caagagcaag ttttgcactt ttttcttcaa agaatgtcac cgtctgaaga atgcgattgg      420

aagacacaca cacacacaca cacacacaca cacacgcagc cggttctcta caggattaga      480

aaaaacttgc gcgaattaat ctgcgtagtt aaaaacaaat acgaaatgag cgagaaagca      540

catagtagtc aaatctcgcc accacataaa caggttaagt ttggaagcac agcccctaac      600

attcggtgct gcttagcatc tccgacttcc ggcgtcctcc gttgctaagg tgaccagagg      660

cgcgtcctaa cgctccgccc aacaaaccat agagtaccgg aaaaagctcg agcagagggg      720

tcggaaaggg aaaacaacta cggctgcggt gtggttggtg gtgagatgac gaccttagtg      780

ctggataatg gagcttacaa cgccaaaatc ggttacagcc atgaaaatgt gtcggttatt      840

cctaattgtc agttccggtc aaaaacagca cgtcttaaaa cttttactgc caaccagata      900

gatgaaataa aagacccttc tggactcttt tacatcctcc cttttcaaaa gggctacttg      960

gtgaattggg atgttcagag acaagtttgg gattaccttt ttggaaaaga aatgtatcag     1020

gttgattttt tagatactaa tattattatc actgaaccat actttaactt cacttcaatt     1080

caagaatcaa tgaatgaaat tctatttgaa gaataccagt ttcaagcagt attaagagta     1140

aatgctgggg ctctcagtgc acataggtat ttccgagata atccttccga attatgctgt     1200

atcattgttg atagtggata ttcctttaca catatagttc cttattgtag aagtaaaaag     1260

aaaaaagaag caattattcg gataaatgtg ggaggaaaac tcttaaccaa tcatctaaag     1320

gagatcatat cttacaggca gctacatgtt atggatgaaa cacatgtgat taatcaagtg     1380

aaagaagatg tatgctatgt gtctcaggat ttttatagag acatggatat tgcaaagttg     1440

aaaggagaag aaaatacagt aatgatagac tatgtcttgc ctgacttcag tacaattaaa     1500

aagggctttt gtaagccaag ggaagagatg gtgttgagtg gaaaatacaa atctggggaa     1560

caaattcttc gtttggccaa tgagagattt gctgttccgg aaatactctt taatccttct     1620

gatataggca ttcaagaaat gggaattcca gaagctattg tctattcaat tcaaaatcta     1680

cctgaagaaa tgcagccgca tttttttaag aacattgtct tgacaggagg aaattccctt     1740

ttcccaggat ttagggatcg ggtttactca gaagttcgat gtcttactcc aacagattat     1800

gatgtttctg ttgtgctgcc tgaaaaccct attacttatg cctgggaagg tggaaaattg     1860

atatcagaga atgatgattt tgaagatatg gtggtaacaa gagaagatta cgaagaaaat     1920

ggacatagcg tctgtgaaga gaaatttgat atttaagcaa catttttgaa tgaaagttgt     1980

gaccataagg tttaatttca aagttccttt taaaagaggt taaggaactg tgttaccttt     2040

tgtcctaaga aaaaggcttg aatttatgta aatactttga tcgattgcta attttcaaag     2100

gcttcttagg taggttacta cagtaaactg taactcagtc cacattttca tttaggagct     2160

agactaccat aacaatgctt atgctgtttc caagggtagg ttatttttca ttaaaagaag     2220

aatgaatgca ttttaagttt aattcttcat agctgaaagc acaaatttaa cggcttcact     2280

ggacagtttt ccttagaagg tagttttgtg tgactgtgac taaactattt tattttaaaa     2340

tgtcattctt atttatacat tctaaagttg gaaagactga tcttatatgt gtataatgtt     2400

tattttgtac ctagagtaca tttaaaaggg tggagactaa gctaataaag tttttttggc     2460

cact                                                                  2464


<210> 172
<211> 4467
<212> DNA
<213> Homo sapiens

<400> 172
gcggaaaccg gaagcggcgg ctgtccgcgg tgccggctgg gggcggagag gcggcggtgg       60

gctccctggg gtgtgtgagc ccggtgatgg agccgggccc gacagccgcg cagcggaggt      120

gttcgttgcc gccgtggctg ccgctggggc tgctgctgtg gtcggggctg gccctgggcg      180

cgctcccctt cggcagcagt ccgcacaggg tcttccacga cctcctgtcg gagcagcagt      240

tgctggaggt ggaggacttg tccctgtccc tcctgcaggg tggagggctg gggcctctgt      300

cgctgccccc ggacctgccg gatctggatc ctgagtgccg ggagctcctg ctggacttcg      360

ccaacagcag cgcagagctg acagggtgtc tggtgcgcag cgcccggccc gtgcgcctct      420

gtcagacctg ctaccccctc ttccaacagg tcgtcagcaa gatggacaac atcagccgag      480

ccgcggggaa tacttcagag agtcagagtt gtgccagaag tctcttaatg gcagatagaa      540

tgcaaatagt tgtgattctc tcagaatttt ttaataccac atggcaggag gcaaattgtg      600

caaattgttt aacaaacaac agtgaagaat tatcaaacag cacagtatat ttccttaatc      660

tatttaatca caccctgacc tgctttgaac ataaccttca ggggaatgca catagtcttt      720

tacagacaaa aaattattca gaagtatgca aaaactgccg tgaagcatac aaaactctga      780

gtagtctgta cagtgaaatg caaaaaatga atgaacttga gaataaggct gaacctggaa      840

cacatttatg cattgatgtg gaagatgcaa tgaacatcac tcgaaaacta tggagtcgaa      900

ctttcaactg ttcagtccct tgcagtgaca cagtgcctgt aattgctgtt tctgtgttca      960

ttctctttct acctgttgtc ttctacctta gtagctttct tcactcagag caaaagaaac     1020

gcaaactcat tctgcccaaa cgtctcaagt ccagtaccag ttttgcaaat attcaggaaa     1080

attcaaactg agacctacaa aatggagaat tgacatatca cgtgaatgaa tggtggaaga     1140

cacaacttgg tttcagaaag aagataaact gtgatttgac aagtcaagct cttaagaaat     1200

acaaggactt cagatccatt tttaaataag aattttcgat ttttctttcc ttttccactt     1260

ctttctaaca gatttggata tttttaattt ccaggcatag caatgttatc tattttaatg     1320

tgtatttgtc acaataacag aacatgcaag aacaatcatt attttatttt ataggcattt     1380

gattactatt ctagacttct ggtatcttct tactaacata aatatctcaa gtagaaaagt     1440

ttttgaaaac taacatttaa aaattaatca gttacagtaa agactttgaa aaagaaatgt     1500

acttgttagg aagtagctta attacccccc attgcagtat tattgttata tatatagtta     1560

atatgttgta catcacaata atatataatt cagtctctag tttccctaga gtcatttttg     1620

aaaccactga ttgcaaacct ccctgacaat ttttaaaagt agtaagccac attacattta     1680

tctttgtaaa aagatttatg gtaactggtt tcttacttga cttttataaa tagtatttta     1740

catcttattt ttgcctttat ttcataagta atttaaaaat cactggattg ctttattata     1800

ttcagggcaa tatggattat ttttatacca aggatttgca tcgtgaatta cattaagtta     1860

tttggcaatt tataatttat tactacttta aatcaaatgt agcattatca cactgtattt     1920

aaattgtcat tttttaaagg aatattttct tcttaagata tatagaggat tttggagaag     1980

agagacagga ggggtaaaac cagcttaagg ttcagcgagc agaaagggac ctgagaggat     2040

gctcactgta agactgttgg acagtggtgt gtattgaggg gatgaatcgg aacgatagtc     2100

tcatgcagaa aatagtgaga ttaagatcat ccttattgtt tctaaattat ttcaatcaga     2160

tgaaagtgat acgattgaaa tgaaatcaca tagttcgtgc tcagaaattc tattttggta     2220

tgtttgtatt agcctttaga aaaaacactc cgtttcagaa ttgttcacag ttttatttct     2280

taggttttta gagttcagga tttcatttat taatttcttc ttgctttttt ggtggaaata     2340

ggctttgttg taaacattaa gaatataaaa tctcctctat atagaaacaa gaattttgtt     2400

aaaaagagaa tttgaatccc ttcctatact ataaaatgct ctatagggag acaaagtgtt     2460

tcttttttct tttatgttta ctgtttatgt ggagtgaaat ataaggctct tggatgtata     2520

acatactcaa aagctgttac actttctctg atctgctgtg atccactgaa aatgtgctgg     2580

ggtttgttct gctgtcactg tttatgctgc tggaacttag cactgtcttg atttgaagca     2640

tatgattgag agccatttga agcaatcttc attaatgcag ataaaacaag tttacatgtg     2700

cagagttaga aaatgacatg ttcaattctg taagtggtga ctttttgagc acctttcagt     2760

attatgtatt tgtaaaaacc attgtttttg gatataaagc taataagcac tttaaaaagg     2820

aaaaggcagc ctttactatt ttttctggtt gagtcattgc tctttagacc tagcatcagc     2880

aatagatttc aaagataagt attaagcgct accctaaagt gtgtaagttt ttcattttgt     2940

catattgaaa aatgatttgc atagtactga atgttgacac acagcttata tgtatttaca     3000

agaatatctt taagtgtttt tttgacacat taaaataaag gaaataagga aattgtaagc     3060

tttatttgga tttttaaata catttttaaa atttcagatg taatttaaca tcacatttgt     3120

ttttcaggta ttgagtttag atgcctactt ttatgagtac catcagctgg acacagtgtc     3180

tcatacctgt atttgcagca ctttgggagg ctgaagcaga tcgctggagc ttatgagttc     3240

gagaccagcc tggacaacat agtgaaacac tgtctctgca aaaaatacaa aaattagctg     3300

ggtatggtgg taagtgcctg tagtcctagc tacttgggag gctgagatgg gaggatgtct     3360

tgagcccggg aggtggaggt tgcaatgagc caagattgta ccactgcatt ccaacctggg     3420

cgacagagcc agaccttgtc tcaaaaaaaa aaaaaaaaaa agaaaaaaga aagtactgtc     3480

tgtcttaaat tttgctgcaa ataaaaatgt actttggatt atttattgtt gaacttgaga     3540

gatagaaata acatcagata tattttttct ttttttttta taattaattt tttttttttt     3600

tttttttgta gagacagtgt ctcactatgt tgcccaagct ggtcttgaac tcctgagttc     3660

aagagatcct cctgccttag cctcccaaag tgctgggatt acaagcataa gcaccacacc     3720

tggctgaaca tcagatattt taaagtgtag cccagagtct agttggtaaa tgttacttat     3780

attgggacta gtattttcta atgtttctgg gatatgctcc ctataaaatg aaatgttttc     3840

ctggaacaat gctaattagg attgcattcc tggccaaaga catgacatca aataagtaat     3900

agacatcacc agcaatgaat tttgaaaagc aaaaaatact attaacctat ataaccattt     3960

aaaatttaaa aaattatgtt ccaagtacct ctattttctg agctagaaga aaccttagag     4020

gccatctgat gatagattcc cagagctgga tggatcccta gggactacct aatctgactt     4080

tctgtccact gcatggattc ttctaaaaag tatgtcactt atttccctac cttattaaga     4140

ctaaataagt ggaacatcat agagctcttt atttataaca gtcattcttt gatagtcaac     4200

tcttaaatgg agacttgaga tgcttaaata ttgtactact gtgcttatct tgtaaagatt     4260

tcataaaatg atagtattgg ttattttaaa aaggctttgg cttatgctga attatacatg     4320

tagcaccaaa atgttacaac tctactaaat ttccttgttc taaactatta tattagctat     4380

aataaatatt agtcatacat gtaacatgtt taatgacaaa taactttctt tatctccttg     4440

gaattaaaga gggcttttaa aagataa                                         4467


<210> 173
<211> 2584
<212> DNA
<213> Homo sapiens

<400> 173
aggaggaggg gccggcagcc tggaagggaa aggacagcgg agagcagggc agagcctgag       60

caggcagggc acctccaggt gggcaggagc taccactcag caccatgagc accgccacag      120

gcccagaagc tgccccaaag ccaagcgcca agtctatcta tgagcagagg aagcgttact      180

ccacagttgt tatggctgat gtatcccagt acccagtcaa tcacctggtg acgttctgcc      240

tgggtgagga cgatggcgtg cataccgtgg aggatgcctc caggaagttg gccgtcatgg      300

atagccaggg ccgagtctgg gcacaggaga tgctgctgcg agtgtctccc gaccatgtca      360

cgctgctcga cccggcctcc aaggaggagc tggagtcgta cccactgggc gccatcgtgc      420

gctgtgacgc ggtgatgcca cccggcagga gccgctcgtt gctgctgctc gtgtgccagg      480

aacccgagcg cgcgcagccc gacgtgcact tcttccaggg cctgcgcctc ggggcggagc      540

tgatccgaga ggacatccag ggggctctgc acaattaccg ctcgggccgc ggggagcgca      600

gggcggcggc gctcagggcc acgcaggagg agttgcagcg cgaccgctcg cccgccgctg      660

agaccccgcc cctgcagcgc cgcccgtcag tccgcgcagt gatcagcacc gtagagcggg      720

gcgcgggccg cggacgaccc caggcgaagc ccattcccga ggcagaggag gcgcagaggc      780

ctgagccggt ggggacctcg agcaacgctg actcggcctc cccggacctg ggtccccggg      840

gtcctgacct ggcggttctg caggcggagc gggaagtgga catcctgaac cacgtgttcg      900

acgacgtaga gagctttgta tcgaggctgc agaagtcggc ggaggcggcc agggtgctgg      960

agcaccggga acgcggccgc aggagccggc gccgggcggc tggggagggc ttgctgacgc     1020

tgcgggccaa gccgccctcg gaggccgagt acaccgacgt gctgcagaag atcaagtacg     1080

ccttcagcct gctggcccgg ctgcgcggca acatcgccga cccctcctct ccggagctgt     1140

tgcacttcct tttcgggcct ctgcagatga ttgtgaacac gtcggggggg ccggagttcg     1200

cgagcagtgt gcggcggccg catctgacat cggatgccgt ggcgctgctg cgggacaacg     1260

tcactccacg tgaaaacgag ctctggacct cgctggggga ctcgtggacc cgccccgggc     1320

tggagctgtc cccggaggag ggacccccat acagacccga gttcttcagc ggctgggagc     1380

cgccggtcac tgacccgcag agccgcgcct gggaggaccc agttgagaaa cagctacagc     1440

acgagcggag gcgccggcag caaagcgccc cccaggtcgc tgtcaatggt caccgagact     1500

tggagccaga atctgagcct cagctggagt cagagacagc aggaaaatgg gtcctgtgta     1560

attatgactt ccaggcccgc aacagcagtg agctgtcggt caagcagcgg gacgtactgg     1620

aggtcctgga tgacagtcgt aagtggtgga aggttcggga cccagcgggg caggagggat     1680

atgtgcccta caacatcctg acaccctacc ccggaccccg gctgcaccac agccaaagcc     1740

ctgcccgcag cctgaacagc actcctcctc caccaccagc cccagccccg gccccacctc     1800

cagctctggc tcggccccgc tgggacaggc cccgctggga cagctgcgat agcctcaacg     1860

gcttggaccc cagcgagaag gagaaattct cccagatgct catcgtcaac gaggaactgc     1920

aggcgcgcct ggcccagggc cgctcgggac cgagccgcgc agtcccaggg ccccgcgccc     1980

cggaaccgca gctcagcccg ggctcggacg cctccgaggt ccgcgcctgg ctgcaggcca     2040

agggctttag ctccgggacc gtggacgcgc tgggtgtgct gaccggggcg cagcttttct     2100

cgctgcagaa ggaggagctg cgggcggtga gccccgagga gggggcacgt gtgtacagcc     2160

aggtcaccgt gcagcgctcg ctgctggagg acaaagagaa agtgtcagag ctggaggcag     2220

tgatggagaa gcaaaagaag aaggtggaag gcgaggtgga aatggaggtc atttgacctg     2280

ccaggcgccc ttcgcaaaga gtgacgaggc cccgtgggag aacggactcc tcagactctc     2340

cccaatagcg gaagtcgatc ttctgaagga tggccaatct gctccggccc tggtcttccc     2400

ccatcccggt ggacagactt aacgatcctt gctgcagtcc ctccggagag gatctggact     2460

ggctgggagt ggggagggcg tggagacagt ctacggaaag cgctagcaga cccccgagag     2520

ggtgcagtgg agccctgagc attgtaatat gcggcccagc ctataaacag cctccgtgct     2580

tagc                                                                  2584


<210> 174
<211> 6287
<212> DNA
<213> Homo sapiens

<400> 174
gcggcggcgg cggcggcggc agcagcgggg ctgggggcgg cgagtggccc gcgcgacacg       60

cgccggcctc gaccctatgc tttgattcgc gtggcgcagg cgcctactgc cccgccggcg      120

gggcccgggc ttcctgccgc gggatgttct cccgaaggag ccacggggat gtgaagaagt      180

ccacccagaa ggtgctggac ccgaagaagg acgtgctgac ccgcctgaag cacctgcggg      240

cgctgctgga taatgtggat gcaaatgatc ttaagcagtt ttttgagacc aactattctc      300

agatatattt catcttctat gaaaatttta tagcactgga aaatagtttg aaattaaaag      360

ggaataataa gtcacaaagg gaggagctgg actccatcct cttccttttt gaaaaaatac      420

tgcagtttct acctgaacga attttctttc gatggcatta ccagagtata ggctcaactt      480

taaagaagct tctacacact ggaaattcta ttaagataag atgtgaagga atcaggctgt      540

ttcttctgtg gcttcaagca cttcagacaa actgtgcaga agagcaggtt ctgatttttg      600

cttgcctggt gcctggtttc ccagcagtca tgtcatccag gggcccttgc acactggaga      660

cactcatcaa tcccagccct agtgtagctg atgtaaagat atatccagaa gaaatcactc      720

cactcctacc agccatatca ggggagaaga ttgctgagga ccaaacctgc ttttttcttc      780

aaatactgtt gaagtatatg gttattcagg ctgcgagctt ggagtggaag aataaggaga      840

atcaagatac tggttttaaa tttcttttta cattgtttcg aaagtattat cttcctcatt      900

tatttccatc atttactaag ttaacaaaca tctacaaacc tgtacttgac atcccccatt      960

tgagaccaaa gcctgtgtac attactacca ctcgagacaa tgagaacatt tacagtacaa     1020

agattccata tatggcagct cgtgttgttt ttattaagtg gattgtaacc ttctttttgg     1080

aaaaaaagta tctaactgca acacaaaaca ctaaaaatgg agttgatgta ttgcctaaaa     1140

tcatccagac tgttggtggt ggtgctgtgc aggagagagc gcctgagctg gatggtggtg     1200

ggcccacgga gcaggacaaa agccattcta acagcagcac cttgtcggac cgaagactca     1260

gcaactccag cctctgtagc attgaagaag agcaccgaat ggtgtatgaa atggtacagc     1320

ggattctctt gtcaacacga ggttatgtca acttcgtgaa tgaagtattt caccaggcat     1380

ttttgttgcc ttcctgtgag atagctgtaa caagaaaagt agttcaagtg tacagaaagt     1440

ggattctcca ggacaaacct gtgttcatgg aggagccaga tagaaaagat gttgcccaag     1500

aagatgctga aaaattagga ttttccgaga ctgatagcaa ggaggcctca tctgaaagtt     1560

ctggtcataa acgatcttcc agttggggac gcacatactc cttcacaagt gcaatgagca     1620

gagggtgtgt gacagaggag gaaaatacaa atgtgaaagc cggcgtccag gctttgttgc     1680

aggtattttt gacgaactct gcaaacatct ttttgttgga accatgtgct gaagttcctg     1740

tgctcttgaa agaacaagtt gatgcttgta aagctgtttt gattattttt aggcgcatga     1800

taatggagct tacaatgaat aaaaagacat gggaacagat gttgcaaata ctactcagga     1860

taacagaagc tgtcatgcag aagccaaagg ataaacaaat aaaggacttg tttgcccaga     1920

gcttggcagg gttactattt aggacgctca tggtagcttg gatccgagca aacctctgtg     1980

tgtacatttc tcgagagctc tgggatgact ttcttggtgt gctgtcctcc ctcacggaat     2040

gggaggaact tataaacgag tgggccaaca ttatggactc cttgacagca gtgcttgcaa     2100

gaaccgttta tggagttgag atgacaaacc tacctctgga taaattaagt gaacaaaagg     2160

aaaagaagca acgaggcaaa ggctgtgttc tagatcctca gaaaggaacc accgtgggga     2220

ggtccttttc tctcagctgg cggagccacc cagatgtgac cgaaccgatg cgatttagga     2280

gtgccaccac gtctggagca ccgggagtgg aaaaggcaag aaatattgtt cgccaaaaag     2340

caactgaagt ggaggagtgt caacagtcag aaaatgcacc tgcagccgga tctggccatc     2400

tcacagtggg acagcagcag caggtccttc ggagcagcag cacctccgac atccccgagc     2460

cgctgtgctc agattcttct cagggtcaaa aggcagaaaa cacacagaat tcgagttctt     2520

cagagcctca gcctattcaa gagaataaag gacatgtgaa gagagaacat gaaggaataa     2580

caatcttagt tcgaagaagc agcagccctg ctgaattgga tttgaaagat gatttgcagc     2640

agacacaagg aaaatgtagg gaaagacaga agagtgaaag taccaacagt gacacaactc     2700

tgggctgtac caatgaggca gagctgtcca tgggcccatg gcagacctgt gaggaagacc     2760

cagaactgaa tactcccaca gatgttgtgg ctgatgctga tgcccgtcat tggttacaac     2820

tgagtcccac cgatgcttca aatttaacag atagcagcga gtgcctcaca gatgactgta     2880

gtataatcgc cggggggagc ctcactggtt ggcacccaga ctctgctgct gtgttatggc     2940

gaagggtctt ggggatcctc ggagatgtga ataacatcca gtcacccaag atccatgcca     3000

gagttttctg ctatctctat gaactctggt acaaactagc aaagatacgg gataatctag     3060

caataagcct ggataaccag tcttctccat ctcctccagt tttgatccca ccactcagaa     3120

tgtttgcatc atggctgttt aaggcggcga cactgccaaa tgaatataag gaaggcaaac     3180

tacaagccta caggctgatc tgtgccatga tgaccagacg ccaggacgtt ctgccaaact     3240

cagatttcct ggtgcatttt taccttgtga tgcacctggg attaaccagc gaggatcagg     3300

atatcttaaa tacgatcata aggcactgtc caccccgctt tttctccctg ggttttcctg     3360

gcttctcaat gctggtgggg gacttcatca cggccgctgc cagggtcctt agcacagaca     3420

ttttgacggc gcctcgttca gaggctgtca ctgtcctcgg ctctctggtc tgctttccaa     3480

atacctacca ggagattcct ttactgcagt cagtgccaga agtaaatgag gccattacag     3540

gaactgaaga tgtcaagcat tacctcataa atattttact gaagaatgcc acagaagaac     3600

caaatgaata tgcaagatgc attgctgttt gctcccttgg ggtctggata tgtgaagagc     3660

ttgcacagtg tacaagccac cctcaggtga aagaggccat caatgtgata ggagtaactc     3720

tgaagtttcc caacaaaatc gtggcccagg tagcttgcga tgtccttcag ttgctggttt     3780

cctactggga gaagcttcag atgtttgaaa cctctctgcc tcggaaaatg gcagaaatcc     3840

tcgtggccac agttgctttt cttttaccaa gtgcagagta ctcctcagtg gaaacagaca     3900

agaagtttat tgtgtccttg ctactctgcc tcttggactg gtgcatggca ttgcccgtga     3960

gtgtccttct ccaccccgtg tccacagcag tcctagagga gcagcattcg gccagagccc     4020

ccttgctgga ttatatctac agggttttgc actgctgtgt gtgtggctca agcacgtaca     4080

cccaacagag tcactacata ctgaccctgg ctgacttgtc atccacggat tatgacccct     4140

tcctgccact ggcaaatgtg aagagctctg agccagtcca gtatcattca tcagcagaat     4200

tgggtaacct gctgactgtt gaagaggaga agaagagaag aagtttggag ttgatccctt     4260

tgactgctcg aatggtgatg gcccacctgg tgaaccacct ggggcactac cccctcagtg     4320

ggggccctgc catactgcac agccttgtca gcgagaacca tgacaatgcc catgtggaag     4380

gctccgagct gtcctttgag gtgttcagaa gtccaaacct gcagctgttt gtatttaatg     4440

atagcaccct catctcctac cttcagacac ccacagaagg accggtaggg ggatcaccag     4500

tgggctctct ctctgatgtg agagtaattg tgagggatat ctcagggaag tactcttggg     4560

atggtaaggt tttatatgga cctttggaag gctgcttagc acccaatgga agaaatcctt     4620

catttctgat ttcgagctgg catcgtgaca catttggacc tcagaaagac tcttctcaag     4680

ttgaggaggg ggatgatgtt cttgacaaat tacttgaaaa cattggccat acaagtcctg     4740

aatgcctttt accgtcacag ctaaatctaa atgaaccttc cctaacccca tgtggcatga     4800

actatgacca agagaaggaa atcattgagg tcattttgcg ccaaaatgct caagaggatg     4860

agtatatcca gagtcataac ttcgattctg caatgaaagt caccagccaa gggcagccct     4920

ccccagtgga gccccgagga cccttttatt tctgcaggtt attgcttgat gacttgggaa     4980

tgaattcttg ggacagaagg aagaattttc atctattgaa gaaaaattca aaattattga     5040

gagagctgaa aaatttggac tcccgccagt gccgtgagac acacaaaatc gcagtgtttt     5100

acattgctga aggtcaagaa gacaagtgtt caatcctctc taatgaaaga ggaagccaag     5160

catatgaaga ctttgttgct ggacttggat gggaggtgga tctctccacc cactgtgggt     5220

tcatgggtgg ccttcagcgc aatggcagca ccgggcagac ggccccttac tatgctacct     5280

caactgtgga agtgattttc catgtttcca ctcgaatgcc gtcagactca gatgattccc     5340

tcaccaaaaa gcttcgtcac ttggggaatg acgaggtcca tatcgtctgg tctgaacact     5400

ccagagacta ccgcaggggt attatcccaa ctgcctttgg agatgtttca atcattattt     5460

acccaatgaa gaatcacatg ttcttcatcg cgataacgaa gaaacctgag gttccatttt     5520

ttgggcctct gtttgatgga gccatagtga gtgggaagct gctgccaagc cttgtatgtg     5580

ccacgtgcat caacgccagc agggctgtga agtgcctcat cccactctac cagagcttct     5640

atgaagagcg agctctgtat ctcgaagcaa taattcagaa ccaccgcgaa gtaatgacat     5700

tcgaggattt cgcagcccaa gtcttttctc cctctcccag ctactccctc agcggaacgg     5760

attaaaacac gtaaaggtct catttcaata tttgagcaag gggccctggc ctccagtctg     5820

agtgctgacc tcgaagagcc cctgagtgag gaggagacag aacaccctct cctgcctctg     5880

ccccgagcca ctaaacccag aatctccagg aaatttcgtt gctgtactag tgccctcagc     5940

aggtcttccc attagtggac ttctgaagcc catggtgaat cccactaccg tgtctcagat     6000

gggactcaaa ctaggctgta tcatcttgtc ctgaaacctc acaaaccttg gacttccaaa     6060

gaagaaaaga aaaagtcacc aaaaaccaga gatgaaccca ctgacacgtg ggcactggtg     6120

tggctgctct gggcagatga cagcaggaaa agattctgcg ctttcaggga gggggcagag     6180

ggcagcttgc ttctgcaccc caagttgttt cttctcattt atgaacccaa gcatgattca     6240

caaaggggct ggcaaaacaa ttgtctaatt gaggaatctg atctgca                   6287


<210> 175
<211> 1746
<212> DNA
<213> Homo sapiens

<400> 175
atgggaggat cttcccccgt gacctcaaaa gctattgtgg atgctgatgg aagaatttat       60

attcggaact ggcagggtgg catcctgtct gggggctttg agaagaaccc gaaaccaatt      120

ttcactgagg gcaagaacca gctggagatt cagaatctac aggaagactg ggatcacttt      180

gagcctctgt tgagttccct tctgaggagg atgccagaat tagagactct ggagatcatg      240

aagttggtga actgcccaga gaccttcaca ccagacatga ggtgcatcat gggcgagtct      300

cctgcagtgc agggctactt tgtcctggca ggaatgaact ctgctggcct ttcatttggt      360

ggaggagccg gaaagtacct tgccgaatgg atggtacatg gttatccctc agaaaacgtt      420

tgggaattgg acctgaaacg ttttggagcc ctccagagca gccgcacctt tctgcgccac      480

cgggtcatgg aagtcatgcc tttgatgtat gatctgaagg ttccccgctg ggacttccag      540

accggtaggc agttacgcac ctctcctctc tacgaccggc tggatgcaca gggagccagg      600

tggatggaga aacatggatt tgagaggcca aagtactttg ttccccccga caaggacctc      660

ctggcattgg agcagagcaa gactttctat aagccagatt ggtttgacat cgtggagtct      720

gaagtcaagt gctgtaagga agctgtgtgt gtcattgaca tgtcctcttt cacaaagttt      780

gagataacat ccactgggga tcaggcatta gaagttctac agtacctctt ctccaatgac      840

ctggatgtgc ctgtgggcca cattgtgcat actggcatgc tcaacgaggg tggagggtat      900

gaaaatgact gcagcatagc acgactgaac aagcgcagtt tcttcatgat ctctccaacc      960

gaccagcagg tccactgttg ggcctggctt aagaaacaca tgccgaaaga cagcaacctg     1020

ctcctggagg acgtcacctg gaagtacaca gccctcaatc tgattggccc tcgagctgtg     1080

gatgtgctgt ctgagttgtc ctatgcccct atgactccag accacttccc aagcctcttt     1140

tgcaaggaga tgagtgtggg ctatgcaaat gggatccggg tgatgagcat gacgcacaca     1200

ggagagccag gattcatgct ctacatcccc atagagggca tggatttcat tggtcgcgac     1260

gccctcctgc agcagaagca gaatggagtg tataaacgcc tcaccatgtt catcctggac     1320

gaccatgatt cagacctaga cctttggcct tggtggggag agcccattta ccggaatggg     1380

cagtatgttg gcaagaccac cagcagtgcc tacagctaca gcctggagcg ccacgtttgc     1440

ctgggctttg tgcacaattt ttctgaggac acgggggaag agcaagtggt gacagcagat     1500

ttcatcaacc ggggagagta tgagattgac atcgcgggat accgcttcca ggccaaggcc     1560

aagctctacc ctgtcgcctc cctcttcacc cagaagcgcc gaaaggatga catggagctg     1620

agtgccttcc ttgcccttcc acctcctcct cctaatattc actctgggct cttcttccct     1680

tcccacccct cactcagctt ctcgtggtgg caggaggtat gtctgacagg acagaagcaa     1740

gctcca                                                                1746


<210> 176
<211> 5804
<212> DNA
<213> Homo sapiens

<400> 176
gaccgctctt tccgggtttg cgagcggaag tggacgaatt tgaatcctgt gggccgttga       60

atgtggctgc tcgcggtcgg cgtgccccga cgtacagcgg gccgggaaaa gtggcactga      120

ggctctggaa cttctgccca gctctccttg taaaatgaat gaaagtaaac ctggtgactc      180

acagaacctt gcttgtgttt tctgtcgaaa acatgatgac tgtcctaata aatacggaga      240

aaagaaaact aaggagaaat ggaatctcac tgtacattac tactgtttgt tgatgtcaag      300

tggaatttgg cagagaggca aagaagaaga aggagtttat ggttttctaa tagaagatat      360

caggaaggaa gtgaatagag cttctaaact gaaatgctgt gtttgcaaga aaaatggtgc      420

ttcaattgga tgtgttgcac cccgatgtaa acgaagttat catttcccat gtggacttca      480

gagagaatgt attttccagt ttactggcaa ttttgcgtca ttttgttggg accatcgacc      540

tgttcaaata attacatcta ataattatag agagtcctta ccatgcacca tttgcttgga      600

atttattgag cctattccaa gttataacat attacgaagt ccttgttgta agaacgcttg      660

gtttcataga gactgtttac aggttcaagc aataaatgcg ggagtgtttt tctttaggtg      720

tacaatatgc aataatagtg acatctttca gaaagagatg ttgagaatgg gaattcatat      780

tcctgaaaaa gatgcttcct gggaattaga ggaaaacgct tatcaagagc ttctgcagca      840

ctatgagcgt tgtgatgttc gaagatgtcg ttgcaaagaa gggcgagact ataatgcacc      900

tgatagcaaa tgggaaataa agcgctgtca gtgttgtggt tccagtggca cacatttagc      960

ctgctcctca ttacggtcat gggagcaaaa ttgggagtgt ttggaatgta ggggtattat     1020

ctacaattca ggagagttcc aaaaagccaa aaaacatgta ttacccaatt ctaataatgt     1080

ggggattaca gattgtttgt tggaagagtc atcacctaaa ttacccagac agtcacctgg     1140

atcccagagt aaagatctac tgaggcaagg cagcaaattt agaagaaatg tatcaacact     1200

attaatagag ttaggattcc aaattaaaaa aaaaactaaa agattgtata tcaacaaagc     1260

caatatctgg aatagtgcct tagatgcatt cagaaatcga aactttaatc cttcatatgc     1320

aattgaagta gcatatgtta ttgaaaatga taattttgga agtgagcatc ctggatcaaa     1380

gcaagaattt ctgagtctct taatgcaaca tcttgagaac tcatcattgt ttgaagggtc     1440

cttgtcaaag aacttgtctc taaattctca agctctgaaa gagaatcttt actatgaagc     1500

tggcaaaatg cttgccattt ctttagttca cggtggtcct tcacctggtt tcttttctaa     1560

aaccttgttt aactgccttg tttatggacc agaaaatacc cagccaattt tagatgatgt     1620

ttcagacttt gatgtggcac agattataat caggataaat actgcaacaa ctgtagctga     1680

cttaaagtca ataataaatg aatgctataa ctaccttgag ttaattggat gtctcagact     1740

tataacgaca ttaagtgata aatatatgtt agtaaaagac atacttggct accatgtaat     1800

tcagagagtc cacacaccct ttgaaagttt taagcagggt ctgaaaaccc ttggtgtttt     1860

ggagaaaatt caggcttatc cagaagcatt ttgtagcatc ctgtgtcata aacctgagag     1920

tctttctgca aaaatcctta gtgagctttt tacagtacac acattacctg atgtgaaagc     1980

tttggggttt tggaacagtt acttacaggc tgttgaagat ggtaaatcta caacaacaat     2040

ggaagacatt cttatttttg caactggttg cagttccatt cctccagctg gatttaaacc     2100

cactccttca attgagtgtc tgcatgtgga ttttcctgtt ggaaacaagt gtaataactg     2160

tttagcaatt cccatcacca atacatataa agagtttcaa gaaaatatgg acttcaccat     2220

aagaaacact ctaagactag aaaaggaaga aagttctcat tacattggac attaaaatgt     2280

ttccttgaac aaagagaagc ttctttaaaa gctgctattg ataactctct tttatttcac     2340

taaccttttc atcatcactt tgaacaaact agttagcttc ttgacctaat aaaatttatg     2400

atatgaatat aaaggaatat tatagccact taggctaaaa aaaggttttt tttgttaaag     2460

catactagtc aaaattggtg ataatttctc attttcttga tatagatact tcataaacct     2520

caatataaat actctcaaaa tggttgtatg gattttattt aggtatggta gcatggttaa     2580

taaaagtaaa aactgtttta ctcacatttt ttgtaaatta ggattacata tagaatgcca     2640

caatttctct aggtttattc aattttcaaa ttattcctca ttttatttta aagcattaaa     2700

tagaaaagct aattggttaa attttgttat ataaatcaga gtcatatatt ctgggatttg     2760

tgttactatg catacttttc taggatgtca ccaaattagt tgtttaaaat gtttttagat     2820

tactgattta tattaagatg acccacactg caattagatt atgcctagtg ggaagtatta     2880

tataaaaagc agaattaagc tgggcacatg tgcttgtaat ctcagttata agggaggctg     2940

aggtgggaga atcgagatac tcagccagcc tggcaatgta gcaaagactc catctcaaaa     3000

aaaaaaacag aattgcacaa attttctgga atctatggac attccatgag cttaaacact     3060

tttgaggtgg ataacattta gttgaaaata cctaagaaag tgtgtcttct ttaaagcctt     3120

ggctttaatc atgggaaatt gttgttgttg ttgttgttgt ttgtatccta tgtttggtat     3180

tctgtatgtc tgatccataa tcattttaga tatttgaatg atctctgtgg attggtaggt     3240

ttggccattt gaccattatt tattatcaag ttggttgtat gctaaggtaa gttgacgcca     3300

tagcattata cagttatctt cattgctctt gaatgatatc tgttatataa gcaatgtata     3360

aataaagtaa aaaggataga atgaaaaacc cattctaatg tcaccactca gagataagta     3420

ccgtatttct gtgtatcctt ctataaactc tttacttctg tttcctttat tttttaactt     3480

taataatgct actaaaagac aatacctaaa agtaactgta ctaacaaagt gctaacaatg     3540

tgaaaatata tagtcccata gtcatgtccc catatttata ctcccacaga agaaaaaatt     3600

ggaaaacaaa gtctgatgtc cttaatctat taacatattt aaatgatata atggttcagt     3660

tttccatgaa agtaaatcat tatgggaagt aaaatgtttt aaccatattt ttcttaatac     3720

acaaagcagg tgtcagctgt tgtattctca cccttcttaa gaaaaatcat tacattattg     3780

atatttttta agtaacagaa tagatttgaa agagataata tatctcttaa taccaaagga     3840

aaactaaaac ataattctag tgtacttttc tttgttccct catgtctttt tcaatctgta     3900

cactaacata cctagcaaat ttgttttact ttaacttgaa atatttaaga acattaaaca     3960

agacatttct ttggctttgg ttgaattttt ttgtctcacc aatagtaatt gaaagatcaa     4020

ttatcaaaga gtttgaatag ctaatataaa ccccaaagtc accatacagt ttttattcca     4080

aatatgttga taaaaagata tttgtttctt tatccacctt atttttatta cagctaaaaa     4140

ccaatacaaa ccaataaaac ctagttaaag ctattttctg gtttttagtt gcaattaatt     4200

tcccctaggg tagaaattaa agctgattaa gtcacacaca catactttgt tggggtgggg     4260

gtggcaggtg gagaggcagt gtacttgggt tagctacaat taaaaacagt atttcaattc     4320

ctcatttgac ttattttata tatagacagg gccttagtga taagatggtg taaataattt     4380

aggatattca tgttttaaag tgaagcataa atatttattt tgcaaaatgt tttctagttt     4440

gaaggatgtt ccattattac catttttaga ttaatctgta tggtcaagga atatcagaga     4500

aacctgtagg ttatttattt tctgcagtgt cattttgtca aatggttggt attataattg     4560

ttcttttctt attaatttta taaccagtgc ataattctta cattagattt taaaaaagaa     4620

ttatgctata aatctttata aatgtgtaca tatatttctt aaatattgca attgcctaaa     4680

tgttgtatat tttaaggctg ttttctcttg ctcttaatgt tgaggaaaac tataaattga     4740

tctataatgc atctactgtt aatggttttg gttagtttga tattcattgt ttttaaacac     4800

tttccaatat ggaaacttta acacctttta tacaattctc tactattcaa gatattcttt     4860

aaaatatctc accagaaact tacaatttta tactttgtaa tttttagttt ctgtaatttg     4920

aggaagtgac tttttttgtt tgggttaagt aaaaagcctt tgattgatta ccagcatgag     4980

aattcacctt ggtttctatt ttatgcattt gtaaattttt cccctaatta tatggaagct     5040

attggaactt ttgtattcag tgctaaatac taagtcaagg ggagtatatt aggtaagttt     5100

tttcagtgac tgtgccttta gcattcagtc attataagaa aatgatcaga acaaaatcat     5160

tacattataa acatgtaatt cttttatata gtgattatca tgtactgcat tgttacttta     5220

aaataagcta ttaaactagt ttttatggtt caagtaatgc aatacaaagt ttcatgcttc     5280

aagtaatgca atacaaaaca taacccattt aatgatgaat tacttgaatg tatattatct     5340

gtggtttagg aaaatttgga ttgtcttgaa gagactcagt tttcaagttc tgattttgac     5400

cattatctct tctaattcat aaacatatcc cagtacctac actatgccag gtattatgct     5460

aggtgatcgt ttatatgtca gcctatttcc ccccctttta aagactgcca gattaaccaa     5520

aaagcgtgac atttataaca atgttttata aataaataaa tgtgtttatg ccactaaagg     5580

taaactgcct atttaaacta agtaattttt tgggatttaa taagattaag attctgacga     5640

aactgaaaga tacaagattc ctttactctc cacatttgag agatcctata agcaagcagt     5700

tagtgtctga cacccaggaa cctatagaaa tgagggaatc tgtgttaaaa ctatgtatcc     5760

tctaatgtaa aatagcttac cagaataaat tatttaagcc aaaa                      5804


<210> 177
<211> 1987
<212> DNA
<213> Homo sapiens

<400> 177
gggaaatcct gagcgcaggc cagggttgtt tggttttgag gtgtgctggg atgaaaggca       60

ccctggaagt ggaaggtaaa tgaacaatgg aaaaacttca cggcaagatt agaaagatac      120

ctgagcccaa tacccgcctg atgtcgtggg ccacacctcc gggttaccag gggaagggag      180

gaagcaaact gtcatattga tgtggctcta aacaacaaca gtgtgcgaag gcccaggggc      240

actttgggat tgaccaagag gaaacacaag ttgcacaatg atacaatctt gttggtacaa      300

ttgtcagaga agggaactcc cacagcaaag gccataaaac catccagggc agtctggggc      360

ggctcagttc tgcggtgcca gggagtggag cagagctcag ccccgtccca aacacagatg      420

ggaccatgaa ctccggacac agcttcagcc agaccccctc ggcctccttc catggcgccg      480

gaggtggctg gggccggccc aggagcttcc ccagggctcc caccgtccat ggcggtgcgg      540

ggggagcccg catctccctg tccttcacca cgcggagctg cccaccccct ggagggtctt      600

ggggttctgg aagaagcagc cccctactag gcggaaatgg gaaggccacc atgcagaatc      660

tcaacgaccg cctggcctcc tacctggaga aggttcgcgc cctggaggag gccaacatga      720

agctggaaag ccgcatcctg aaatggcacc agcagagaga tcctggcagt aagaaagatt      780

attcccagta tgaggaaaac atcacacacc tgcaggagca gatagtggat ggtaagatga      840

ccaatgctca gattattctt ctcattgaca atgccaggat ggcagtggat gacttcaacc      900

tcaagtatga aaatgaacac tcctttaaga aagacttgga aattgaagtc gagggcctcc      960

gaaggacctt agacaacctg accattgtca caacagacct agaacaggag gtggaaggaa     1020

tgaggaaaga gctcattctc atgaagaagc accatgagca ggaaatggag aagcatcatg     1080

tgccaagtga cttcaatgtc aatgtgaagg tggatacagg tcccagggaa gatctgatta     1140

aggtcctgga ggatatgaga caagaatatg agcttataat aaagaagaag catcgagact     1200

tggacacttg gtataaagaa cagtctgcag ccatgtccca ggaggcagcc agtccagcca     1260

ctgtgcagag cagacaaggt gacatccacg aactgaagcg cacattccag gccctggaga     1320

ttgacctgca gacacagtac agcacgaaat ctgctttgga aaacatgtta tccgagaccc     1380

agtctcggta ctcctgcaag ctccaggaca tgcaagagat catctcccac tatgaggagg     1440

aactgacgca gctacgccat gaactggagc ggcagaacaa tgaataccaa gtgctgctgg     1500

gcatcaaaac ccacctggag aaggaaatca ccacgtaccg acggctcctg gagggagaga     1560

gtgaagggac acgggaagaa tcaaagtcga gcatgaaagt gtctgcaact ccaaagatca     1620

aggccataac ccaggagacc atcaacggaa gattagttct ttgtcaagtg aatgaaatcc     1680

aaaagcacgc atgagaccaa tgaaagtttc cgcctgttgt aaaatctatt ttcccccaag     1740

gaaagtcctt gcacagacac cagtgagtga gttctaaaag atacccttgg aattatcaga     1800

ctcagaaact tttatttttt ttttctgtaa cagtctcacc agacttctca taatgctctt     1860

aatatattgc acttttctaa tcaaagtgcg agtttatgag ggtaaagctc tactttccta     1920

ctgcagcctt cagattctca tcattttgca tctattttgt agccaataaa actccgcact     1980

agctgca                                                               1987


<210> 178
<211> 11528
<212> DNA
<213> Homo sapiens

<400> 178
ttgcgcagaa ggcggcggcg gtggtggctt gtggtgcggc ctcaccatac aggaacaggg       60

cagacgttag cgtgagtgat cactctcaat cccggggacc tggtggcctt agtctttcag      120

gtggaacggt gtgcgacatg ggaaagaaaa ccaagcggac agctgacagt tcttcttcag      180

aggatgagga ggagtatgtt gtggagaagg tgctagacag gcgcgtggtt aagggacaag      240

tggaatatct actgaagtgg aaaggctttt ctgaggagca caatacttgg gaacctgaga      300

aaaacttgga ttgccctgag ctaatttctg aatttatgaa aaagtataag aagatgaagg      360

agggtgaaaa taataaaccc agggagaagt cagaaagtaa caagaggaaa tccaatttct      420

caaacagtgc cgatgacatc aaatctaaaa aaaagagaga gcagagcaat gatatcgctc      480

ggggctttga gagaggactg gaaccagaaa agatcattgg ggcaacagat tcctgtggtg      540

atttaatgtt cctaatgaaa tggaaagaca cagatgaagc tgacctggtt cttgcaaaag      600

aagctaatgt gaaatgtcca caaattgtga tagcatttta tgaagagaga ctgacatggc      660

atgcatatcc tgaggatgcg gaaaacaaag agaaagaaac agcaaagagc taaaggaggg      720

gatggtctct gtcatttctc tttgtacata atacattcac ctccctgcct cctctccttt      780

ctacccaccc ctttctatcc taaacacatc cataaaaaat gtgcttatca ctgtgctcca      840

caggagaaat gttggtattg gttctcttgt aacataactg atggtctgat taatgataag      900

tgtctctctg tgaagaccag gcatttacat actgagtgta atacccacaa tttttttttc      960

ctttgccctg atctcttcct tctgcttccc tgtgacctca agatgagttt caacttttta     1020

atcaccttag agtcttgatc ttttcagggt tggtcgcttt ttaggttggg ggattttgtt     1080

acaatgatgt tgaattttgg tttcttgctt tggttcttag aacatgttgc tgactagctg     1140

gcctttgttc tgacatgttg agatggaaag gatgttgccc atctgttaaa aagccaatag     1200

caactgccta cctgttgggg ctttcccaac cttgttcagc tctacccagg agaatacagg     1260

gtttctggtg tggtcttctg ggccaccctc tgttgttcat cctcactcat cctcccagaa     1320

ttactccatc ctttggaaga tttgaaattt tacactgaaa tctgtcaaga cactcttttt     1380

agccccagga ctttcggtat tgcttttagc actccccact tctgcttctg taaagtgata     1440

tcaatttgtg ataaaatgac aagattatta actgtgcaga tttgtagcta tagtacatga     1500

ggatgatggg gtagggtaca attgtcttta ttatcatata tggtatgtat gtatgatttc     1560

tttccattcc tcatatttag actgtatatt tatgtaggtg tgagtgattg cctggtgctt     1620

gcttgtgcca aggtgctagg caccctccaa ccctgccaac ttttgtggcc tcccaaagca     1680

ttcctgttac caaagaggct tcaaacctga ccctcacttc tcagtggacc cgagtttccc     1740

ttccatgcca ttattttcag tggggaagtt ttagaggtga gctgttggcc acaatatcaa     1800

ttttaagtgt tcatagcagt tatgtctcct gcattcttgg ctcctggatt taccaccaag     1860

agtccccaaa atattaatgc tcttcccttt ttctaccctc aaacttatag ttgtatctta     1920

ttttttaaaa tgaattttca tggccaggca cagtggctac cgcctgtaat cccagcactt     1980

tgggaggctg aggcaggaga attgcttgaa gccagaagtt tgagaccagc ctgggcaatg     2040

tagtgagacc ccctgtctct aaaaaatata aataaaaata aaggcatgtt cctgaaagac     2100

tgtcaccttg gaaagtgaca ggccctggca ttagcatgtt gacacaccct tttcttctta     2160

ctcagcaaaa tacttcgttt tggtttcttc ttgtgttgct attgagaaat ttgtctgatc     2220

atatccttct gcctttgtcc cccaagaaat gccctacttt atccttttct ttttgtagtt     2280

gaggagggct agagaatcac aattaaaagt aaggaaatag cagggttttg aggatccttg     2340

tcccagcccc aaagctgagg aaataagaat aaatgcttaa tatagcctta attctagagc     2400

gcaccagcca tgaggctgct tttcttgttg tttttgattt ttaaaacata cagctgtctg     2460

gccaggagca tctaccattt ctagattatt cagagtaatg aggggaatgg atggattgct     2520

ccagtccaca gatgagccac ataatatgca aatcatatac ccattcatag catttgttaa     2580

cattgcttcc ctgctcagct gctgattgaa ttctgtgtgc ttatataaat tatgtcaaaa     2640

attatactgc ataattgagg tgacagctgt tgctgcagtg acatgacaga ctggaacaat     2700

gaagcttttg gtttaagtca gccaggaaaa tccttctgaa tggtaatgtg attgggcaag     2760

agctcataaa ccatacctca agtgggtggg agttttatct ctatattcct tctctctctg     2820

aaggaattaa aggcctagat caagtgctgg ataattgaca attgcttgta cttaatctga     2880

tcggtatcta aaagaaggaa aggatggtca ggaaacattt atcataaatg tagccaagga     2940

tatcaattag ggtagacaag aataggacaa aaataggcca gagctcctga ggaggtgata     3000

tgggtctctt gatttgcaga aaatgacagc ctatccaagt ggcccagtgt atgcctccca     3060

gtagcagtgg gcatgtaaac tgcagcgacc ttatttttaa aaccaaaaac ctagtatgtg     3120

gacaaagaac atgacaatat ttggtactga gattggttct gagaaacctg gggcatgtgg     3180

ctgctgtggt tataggtaat atttaagaca ttcataaaaa tctgatattc ttttaccgaa     3240

ataaccccag tatcatctac tacttaccat ctgttaatag actttactct gtcttttttg     3300

tcttcggttt attgtactga gtgccgccaa aacaactttt gttctcttcc tgcctacctg     3360

cagctggttc tataggaatg tagggagcca gaggccagta ttgatttcag cccttagcac     3420

aaaggaaatc agatgcctgc ttccagcatt tgttagtgtt gagtagatgt tcttgcccta     3480

gaagaattac agcctcaaac agaaacctgt ttcatggagc tttctcccct cagaagagtt     3540

aatagttaag agctaagcac tcttaaacac ctaagtctca aatgctaaaa atttattttt     3600

cttgtgttta gtcctctttc aagacatctt tctaagcctt tcagtaatca acattaaaag     3660

atctcccttt cttcagagtt atagcacagc tttgcccagt agaggctacc aaggacagct     3720

tagcagccct ttgattgctg ggctgggcag atggccttca agttaagatc aaatgccggg     3780

aaaatcagcc tacatgggag cacccatttt aaacctggag agaaccatga tgttttcttc     3840

ttcaaataac aatctagttt tttttccccc agtactaaaa ttgtattgtc tttcagacaa     3900

tataattttt atttaaaatt ggaacatact atcttcatgc tttctaagct aaatcttcat     3960

ttagatttca ctcctcagta gatcccagag aagaagctat ataggatcca gattcaaatt     4020

taacagtgtc ttctactttt ttagttatgt tttctatcaa ctcctgctgc cttttcaaat     4080

acggatattt ttcaggagac tcttctactt gtccactgac tgtatttttt cctttttgat     4140

ccgtagccct ggttaaatgg ctgacatcct tccgtggatg attcttggag gtagtctcag     4200

aattccaaag tgattgtctg tcttcttctt gtcttgatcc taatgcagac attcacctct     4260

attatttatt tatttttttt agacagagtc tcgctctgtc accaggctgg agtgcagtgg     4320

cacaatcttg gcttactgta ccctccacct cctgggttca agcgattctc ctgcctcagc     4380

ctctcgagta gctgggacta caggtgtgtg ccaccatgcc cagctaattt ttgtattttt     4440

ggtagagatg gggttttacc atgtttgcca ggatggtctc gatttcctga ccttgtgatc     4500

tgcccacctt ggcctcccaa agtgctggaa ttacaggcat gagccaccgt gcctggccac     4560

ctctattaaa tttttgtgga caaaaataaa attgtcatta tttgtttgct ctcatggagc     4620

actttcagta atacaatttt ttttaaattc cagttgccct ctttgttgct ctgtcctctg     4680

taatacctga ctttgctaaa gacttgaggg gtggtttcag aggagggtca ggtgatggga     4740

aggcaggatg agaaaagccc tggacttgca tgtttgagaa ggcttccaac cacatcttca     4800

ctcagactct tggaattcct gtccccaaaa caagcttctg ttttttgctc acaatgctat     4860

atttctaaat ttttcctgaa ttactgagaa gcagtcatta gctttgttaa gtttggtttg     4920

gggacattgt tggtatcaaa aatcgaagtc ttattcattt gatgtaggcc atgaatcatc     4980

aataactggt tgctggaaag cttgactacc atccactggg gtgctatttt gagaaggatt     5040

tttgggtatc tttatagtct gcaattagtt gatgattgct ttctagttta tcaactgcat     5100

ttatatttgc ttttctgttc atggaaaatc ctttatttgc tggggttttt tgtttgtttg     5160

tttgtttttc ccacttacag caagtaaaag tggtctgagg ttatccttgt ttttcttcgc     5220

ggtttgccat gtgtgaaagt agatttcctg ctattgatat attctcatta tagacagaat     5280

agtggagaac agtgttgcca tggacaaaat ccagttttgg tccactctgg ggagcatttg     5340

gacctgtggt gcttctaaca attaaaagtc tagatggtcc ttgactgtcc cccagccata     5400

ctgcatacta ctttgtgcat tctactttgt gtcattaatg aaagattggt tctgtccctg     5460

taacttaggc atttattatt cttaactctt cattcctgtt ctgtagccac ccagcagtcc     5520

attttcccta tgttcaggcc aaaccacagg gcattgggga aggtttttgg gattttctta     5580

ttgagatttt gttgaatctg tagtttaccc cagctttcct aaggtacagt gaggggttgg     5640

agggatctgt gtttggcccg gggagcaatt gtctctacct taaggttcag ttttgagggc     5700

ataaaatact actttgcaat gtcatgagaa caccgttaga tctgaaatgt ggaaatggtt     5760

tctcacaatt taaaggaaaa acccactttg cacccatgat cccatcattt tggttgagat     5820

tttagaataa aaaatatagt gttgagatcc gtacttttgt aatcagacca ccaagcatgc     5880

ctgtggcaag gcagagagga aaggtctgga gccagtgtat tgcagtttca tgctaccttt     5940

acctgctaat cataaaaatt atgttttcaa aagtagatga tactagcctt acacccaaaa     6000

acatgttctg aattagatgc cccctcaccc aatttttatt aagctttcta aattccagcc     6060

acattgctgt acatcaacat tggtttcatt caacagacat ttttttggcc tgaagataca     6120

aggttcagaa agaggccatc cctgccctca aataactttc atactggtgt atgatgaact     6180

gaccattaat agtttaagtg cttacaagct atgtttctgt tcaaaaaaaa aatagtttgg     6240

tataataaat gctataaacc aatacacatt tctgacttgg gggcagagac agactggctg     6300

atgttgtata gtttgtagcc ctggagtaag aagttgacat taatttcggc ctatatgtgg     6360

aaaagaccta taacattggg tgaactgagc cagctggcca tagaacacaa gaacatattc     6420

caggaaataa atatagctgg agggttggaa atgctgttat tactgagaga gaaaacaggt     6480

gagttgggat tgagaactcc tgattttcat ccctggttta gattcttggc caaagtagtg     6540

gtagagttaa tctttgcttg tggaaagcat taactatgtt gcagattcag ttgtgttaca     6600

ttattgtggg ttctataaca acatattcct catggacact ttaccagagt tgctcacacc     6660

tttttcaatt tctcatccct tttggaggaa tgaacatgag acttaactgc ctttaagcct     6720

aaaacggaca tgctttccaa tgacaagaga ttttctaaag agaagtcttg gagcacatct     6780

gttaatacct gagcatctac tctgagcagt gcagttttat tcaatactgg agagagggtg     6840

atttcttttt ttttgagacg gagtcttgct ctgtctccca ggctggagtg cagtggcgca     6900

atctcggctc actgcaagct ccacctcccg ggttcacgcc attctcctgc ctcagcctcc     6960

cgaggagctg ggactacagg cgccggccac cacgcccggc taattttttg tatttttagt     7020

agagacgggg tttcaccttg ttagccagga tggtctcaat ctcctgacct catgatccac     7080

ccacctcggc ctcccagagt gctgggatta caggcgtgag ccaccgccgg gccgagaggg     7140

tgatttctaa gcagagaatt gtatcagtta tgtggaaacc tttgccagaa atacatatac     7200

cttgtatatt aaatctgagt ctcagattta atcatcgaag cgtagctggg ttaagaaaca     7260

gtctgatcgt aaggatgttg tcgattctga cccatggatg accacaagaa aaagatattt     7320

atttctgcct ggataattga gagttgacta actttggaag tcagaattcc caggaattag     7380

agtaactgct ctggaaagtt aaagtgtgaa gttttttaga tagtttcata aaaacaattc     7440

tggtttcttt ttgcttgtgc tgactttctt ggattttaat ctacctcatc ttgtcttttt     7500

agagttactt caacttgtca ctttaacatt gtgcttgact ttggttgttt tctaagatgg     7560

aatttttcct gttcattgac agcttgttct cttgcctttt cattctgatc ctcatttcat     7620

ctaacatcat ctcatattgc tcctctgtca agagaaatgt tttaaaatag tttaaagtct     7680

tgttttatgg gaagaaagtg atcctccaat gctatttgtt tctgaggtca gtaagagaag     7740

gagttaaaac aaggcagtgg ggaagggaat gaatcctgca ctggaggcaa aagctgacaa     7800

ggaaagagcc attaattaag acaatttcaa agtcaactga ttgtgatcat taatgtcaca     7860

atagatcaaa acctaattat cacagcctag gtaagagcca tcagtattaa tcggaaaatc     7920

taataggaaa ctattatcaa gaaattaggc caaattgaat gcagtgaact ttttatcttg     7980

gcattctcta tttttttgtg atgtcccctg gcattggcag gtgtgaccct aacagtcgat     8040

tcaaggccaa gtggtcagtt tgtcagcctt ttttaaggga tttcttttta tttttaggaa     8100

ttccaaacag agttaaccta aactgtcatt gccaaaagat cagtcttaaa ctttcttagc     8160

acctgtacct gtttaatgtg atcagctatc agtgaggaaa aaaaaaaaaa tctatttagg     8220

tcttggaatg gttcctgtac ctagagtatc catattgaac cttttttttt tttttttttt     8280

tttttttttg agatggaaac ttgctctttt gcccaggctg gagtgcagtg gcgtgatctt     8340

ggctcactgc aacctccgcc tcccgggttc aagcagttct ctgcctcagc ctcctgagca     8400

gctgggatta taggcgcctg ccaccatgcc cggctaattt ttgtattttt agtagagaca     8460

gggttcacca tcttggccgt gctggtcttg aactcctgac cttgtgatcc gcctgcctcg     8520

gccactcaaa gtgctgggat tgcaggcgtg agccagcacc cggccacagt atctttatta     8580

cagctcactg cagcctcaat ctcctgggct caaatgatcc tcctgcctca gcctcccaag     8640

cagctgggac tacaggcgca caccacggtg tctggctaat tttattattt aaaaaatgtt     8700

ttgtagagac agtctccctg tgttgcccag gctggtctcc aactcgtgag ctcaagtgat     8760

ccacgtgcct cagcctccca aagtgctggg attacaagca taagccaccg cacccggccc     8820

ctagtgaaca ttttactgta tgtgttgata aatcatcttt tgagtttctg ttgtatgtgg     8880

ggacttccta cactggctgc tgtgaagagg tatggaagaa aggagaggct ttctgcctag     8940

aaattctttg agaacacctg aaaagacagt ttaatcatgt cacaacactc ttaaggctca     9000

agtcagtgtt ctggtttccg gtagctttag gattggattc taaacgaggg ctggtggtga     9060

gtttggtgtt tgtctcgtgt caccctcacc cctcacctcc tcagtttagg ataagagaca     9120

taatgatttc taccagaatc caaagtaaat ccaaaggggg agaaaagaca taactgtttt     9180

ttcttctacc ttttttttgt taaagagtta catctctcac aggaggaaag aattcaagag     9240

tctatatgat tagttacaga gaatattttc atcccctctc cctgaataga aaagcagggg     9300

tcaccatttg tatccttacc cttgaggtgt ttttgaagat gctgtaactc ttgaagttga     9360

gctgaggcag aaaggttgga aaaatgcagc cctctgggta ttgtggggag ggatgtgatg     9420

tagtaagagg gtgttttgtg gtgctaggat tcccacgcca ccaacttgca gctttataag     9480

agcgctacca agaaccacca ctggggaaaa ggttcttatt cattgtttct gttggaatgt     9540

gatcttgctt tctggatttt aggaattcag gttactcagt ataaaactct gagaaatcag     9600

tgtgacttag tccttcacct cctaagataa agtgaatatt tctttacaaa ataattcatg     9660

tccttaatgt taaagatgta attttatttt caaaacatct ataacatgac tttcagaagc     9720

agttcatttt tccaagattc ctcacattat actagataaa taataggccc tcagttaata     9780

cccttcagtt attgaattaa tctagtttgt ggaatgaggt gtatcctgcc aacttccctc     9840

tgctcccaag tacactctga gaggtaaaat gctctgggaa atggaacaag aatcgagtgg     9900

atgctgactc tgtgtgccca cctcctcaac tgattgataa tggttgacct tgggcaagtc     9960

acttctttca atgcctcagt tccccatctg tcaaatgggg ttaataatac tgacctacct    10020

cacaggggtg ttgttgtgag gcattgtaaa tcaaagttaa tagaatactt cagggtcctc    10080

tgtggaggat gtcttgagcc agagtttaag cctgacacac aggctttggt cctcactgag    10140

ctgtctccaa gactggaact acttagtgac tcggcaaatt ttctgccccc cacccctcat    10200

caaagctgct agttcagatg ttgacagtgt tttcatgaat gttggaatct tactagtcca    10260

gacttactta ggatgttgtt ggggaaggca cttgggattt tctgtgtctt gcattcacag    10320

agggaggcca tttcagattc aagagcattg gattagggaa tcgtgaggca gggatgctac    10380

tgcgtatttc tctctgcagg ttggggatta aagttccttt ccccatgggt ttgaagcaga    10440

ctcagactgt ctcaggatca aagcaaccct caatggtttt gatttatgtc attgcttacc    10500

actccccaac caatcccagg acagctgggt cactgtaccc ctttgtggta tctgtacctg    10560

ggcctctcct tcctcatagg gaccagctga ttgaataaat gtgaccacct tatttccacc    10620

ccccaccccc aaaagctaca ttggaattat ttttcctaga aatgtgtata acactcagaa    10680

ttgggcattg atccttaaag cttcatccca ttcaccgtat tcaacatctg tcatctctta    10740

gtgtctgcag tctgaaccta accttgacct tttttccctc tggtttgaga aaactttgga    10800

cactatttct acttggccag gtgtgggctc aagagcctta ctctttccat ctcagtttag    10860

gggcgcagcc agctcctctt cccaataggg ctctttctgc tttccctctc cttggcccta    10920

gatttgtaat ccatgaaaaa gcacaaggtc ctggctcctt gcggtcacat tctggttctc    10980

tgtgttttgt ggactctgct ctcactgttc acccagcact agcagtacca gatggttctg    11040

tggagtcctg gggaatggag agagcacagt ctgactccct gccaagtagc caggagttga    11100

cttgcccatg gtccgctggc tttcccacca cttcctacag gatgggatct aagagactca    11160

agagctgggt ttctttcagc actctgtact gtcccaaata gcaaacaaat cactttgtag    11220

ccagatttct gaatggaaat gagaaattga attctccatg gacttttagg tttatggggg    11280

agttttagct gtgtttcttg gttttatttc agccaaacat gtctgctttt gatttttttt    11340

ttaaagtata agtggtctat atatatgttc accttttaaa tgtaaatgtt taaaaagtaa    11400

gcatttatgt gtttccataa ctgacatctg atgcagacct cattctctcc ccctcttcta    11460

ccctcctctt ttcccccttt tcatactctt gtattggttc taataaatgg ttgcttttca    11520

aatatgga                                                             11528


<210> 179
<211> 3421
<212> DNA
<213> Homo sapiens

<400> 179
ctgcctgcgt tagcggcggt ggaggaggag gcagagagga gtggagggcg gagtagacgg       60

aggaggctgc tgcagagaag aaagtgtcag agccggttcg gctttagagt gtggtgaagg      120

gtacttttca tggtgcatgg aaggaaagcc aatgcgcagg tgtaccaaca ttcgaccagg      180

agagactgga atggatgtaa caagccgctg cacccttgga gaccccaaca aactgccaga      240

aggggttccc caacctgccc gcatgcccta tatctcagac aagcaccctc gacaaacctt      300

ggaagtgatt aaccttctga gaaagcaccg ggagctatgt gatgtggtgc tagttgtggg      360

cgccaagaag atatatgccc atcgagtcat tttgtcagcc tgtagtccct acttccgagc      420

tatgtttaca ggagaattgg cagagagccg tcagacagaa gtagtgatcc gagacattga      480

cgagagggct atggaattac tgattgactt tgcgtatacc tcccagataa cagtagaaga      540

gggcaatgtt cagactcttc tgccagctgc ttgcctcctc cagctggcag aaatacagga      600

agcctgctgt gaattcttaa agagacaatt agatccttct aactgcctgg gcattcgggc      660

ttttgctgac acacattcat gtcgtgagtt gctaaggata gcagacaagt tcacccaaca      720

taactttcaa gaggtaatgg agagtgaaga gttcatgttg cttccagcca atcaactcat      780

tgatataata tccagtgatg agctaaacgt tcgcagtgaa gaacaagtgt tcaatgcagt      840

gatggcctgg gtcaaataca gtattcagga aagacgtcct caattacccc aggtgctgca      900

gcatgttcgt ttgcctttgc ttagtcccaa gttcctggtc ggcacagtag gctctgatcc      960

cctcatcaaa agtgatgaag aatgcagaga cttggtagat gaggctaaaa actacctcct     1020

attgccgcaa gaacgaccac taatgcaagg accaaggacg agaccacgga aacctatccg     1080

atgtggggaa gtactctttg cagttggtgg ttggtgcagt ggagatgcca tttccagtgt     1140

tgaacgatat gatccacaga ccaatgaatg gagaatggtg gcttcaatga gcaaaaggag     1200

atgcggagtt ggggtcagtg ttcttgatga tctgttatat gcagtaggag gccatgatgg     1260

atcctcttat ctcaatagtg ttgaaaggta tgaccccaaa acaaaccagt ggagcagtga     1320

tgtggcccct acaagcacct gcaggacaag tgttggtgta gcagtacttg gaggctttct     1380

ttatgctgtg ggtggccagg atggtgtgtc ttgcctcaac attgttgaga ggtatgatcc     1440

gaaggagaac aagtggactc gggtagcttc tatgagtacc agaagactag gtgtggctgt     1500

ggctgtgtta ggagggttct tatatgctgt aggtggctct gacgggacat ctcctctcaa     1560

cacagtggaa cgttacaatc ctcaggaaaa cagatggcac actatagccc ctatggggac     1620

ccggaggaaa cacctaggct gtgcagtata tcaggacatg atctatgctg taggaggtag     1680

agatgacact acagagctga gcagtgctga gagatacaac cccagaacca accagtggtc     1740

tccagtggtg gccatgacat cacgccgtag tggagttggc ctggcagtgg tcaatggaca     1800

gctcatggca gtaggaggtt ttgatggcac aacatacttg aagaccatag aagtttttga     1860

tcctgatgcc aatacatgga ggttatatgg cgggatgaat taccgtcggc tagggggtgg     1920

cgtaggagtt attaaaatga cacattgtga atcccatatt tggtgaacac agagaagaca     1980

gtcttgtata tattcctctg tattctgggg agctttgacc ttggagcttt gtacagcttg     2040

agaaaacatt agaacaaatt ttattatttg ccggtgcctc aacaaatgga aatacaatcc     2100

aatgaaagta cttcacctgc aagatgcaca ataattttca actctgtgca gaagaatatt     2160

tatttttggt tttaatttat catggttttt tgttgttttc gttttgaact tatccttcct     2220

cccacaaaaa aagaaaagaa gaaaaaattc caagcagcaa aacttacttt gtttgtaagg     2280

tattcattta ggtttgaaaa tactatttaa taagggcaga agggctatat atgatttggc     2340

tattatttct agacactcca tccacatgat tccactaaca aggattacca ggaataaagg     2400

taggtatgca aaatgtatta gctacccatt attctcgcac taaccaccag aagacttgaa     2460

aatcttaaaa aaaaaaaaca aaaaaacaag aaaaggcaac atctcatttt aaatagtaca     2520

attcagaagg gatactaaat caataaaaac caggactcag acactacagt tttcatcagt     2580

gtaattttat gtcttgtttc tttctatatg aacttgttta tttagtcttt ttttcataat     2640

attctcatag agtttctgct agatctagag ctctgctcag tgcctcttat aaaaacaata     2700

tataagtctc atatgctgtc ttgagaatcc aagagaatca catgcagctc tgcaacagtt     2760

tttgctcaaa aatgttactg actaaagcaa ctgtccttcc tgtttcctta ttgctaccaa     2820

ggaccagcag ggagaaatgt cttctcccag cagtgaattc tgttatgcaa tttattcttg     2880

atgctcaggc ctggttaagc tgaggcttac ctttaataac agcctccaag ggaatgaatt     2940

attcagttaa tgtaatagca cacattaaag agtgtaaaat caattgaggc attttattaa     3000

tatcttggtt cttttataca aacaatgtat cattatcttc attctataag gtcattgtta     3060

ctacttctct caaattgcac tttctggtaa aaagttaaaa atttttaagg aaaaaataat     3120

ttcaatggtt aaagtttttt ttcctcattg tattcataga caaatttttt tcaatatatt     3180

ttgcaagaaa aatctttgaa taagactaac tgcatttaaa aggaataacc tccttctccc     3240

tttccccaac tacaaaaatg tttggcaact ttgtgtttac atttaaagat catttgcacc     3300

tttttcaagg aaaaaaagta ttgagtaaac aattgtttac atatatcatt tatgcttttt     3360

tctagcatgt ataacttttt taaataaagg tagtatttac cattaaaaaa attttagcta     3420

a                                                                     3421


<210> 180
<211> 1553
<212> DNA
<213> Homo sapiens

<400> 180
agttagggca aaagccaact tccggtcacc atcttgagtg acgacagagg cggagctcca       60

actgacatgt tcattaaggg cagggctccg agggcgccac ctcgagagcg acggcgggct      120

acccggggcg ggctgaggca ggttgtagcc ccgccccggg ccttgggctc cacctctcgg      180

ccccacttcc gccgggcaag cgtttgtagg cggcgctgcc gtaaatcagg cggtctgctt      240

gccgcatcac gcaagatggc ggccgcggcg gtgaacgggg cggcaggctt ctcgagctcc      300

gggcccgcgg caacctcggg cgctgttctg caggccgcga ccggcatgta cgagcaactc      360

aagggcgagt ggaaccgtaa aagccccaat cttagcaagt gcggggaaga gctgggtcga      420

ctcaagctag ttcttctgga gctcaacttc ttgccaacca cagggaccaa gctgaccaaa      480

cagcagctaa ttctggcccg tgacatactg gagatcgggg cccaatggag catcctacgc      540

aaggacatcc cctccttcga gcgctacatg gcccagctca aatgctacta ctttgattac      600

aaggagcagc tccccgagtc agcctatatg caccagctct tgggcctcaa cctcctcttc      660

ctgctgtccc agaaccgggt ggctgagttc cacacggagt tggagcggct gcctgccaag      720

gacatacaga ccaatgtcta catcaagcac ccagtgtccc tggagcaata cctgatggag      780

ggcagctaca acaaagtgtt cctggccaag ggtaacatcc ccgccgagag ctacaccttc      840

ttcattgaca tcctgctcga cactatcagg gatgagatcg ctgggtgcat cgagaaggcc      900

tacgagaaaa tccttttcac tgaggccacc cggatcctct tcttcaacac acccaaaaag      960

atgacagact acgccaagaa gcgagggtgg gtcctgggcc ccaacaacta ctacagtttt     1020

gccagccagc agcagaagcc ggaagacacc accattccct ccacagaact ggccaaacag     1080

gtcatcgagt atgcccggca gctggagatg atcgtctgag ccccccgggc actgggtggg     1140

gcagggcacg agttatttaa aacagttaca ctgcagggtt tcgcccaata aaggtggact     1200

gacattccct cttccaggcc cttgtctccc cagttgggac ggcagagaga caagttctta     1260

tatctgaaga acttggaggt tttggggcat tcaggagttg gagatagcct ccaactgggt     1320

cagcctctgt ctggtgggca ttgctcaggg tctcaaacat ggacgcccac tgtggggccc     1380

cagcagcact gtggcctgca ggagggcatg gccccaggta gggggactgt tctagccagc     1440

tgtggacaca taggaatgct ggaccagggt accagatttt ttcaacaaag ggggtgaagt     1500

gtcctactaa aaagaataaa tgttggcagt gaattaaaca atttttcaaa tga            1553


<210> 181
<211> 1763
<212> DNA
<213> Homo sapiens

<400> 181
aagcaactct cctccaactg tctttaggga taaccctgag cgggcagccg ctctactcta       60

tacctaactt tatccgtacc agatacctag cctcactcag ggcccccctt acctggcggt      120

gccgggatca acaaatgaaa ttgtgacggg aagtcctggc ccttggccca acctcctgct      180

gtccccggtc tgagggccca agccccgcgt ctccgccttg ccgtccagcc tgtccttggt      240

gtggggtgct tggaagtgtg agcaccctct ctggctcttt gccggcccca agggtcgttg      300

cggcggcccc cgggcccagt catcagccct cttttccggt gccggaacta tcgtactggt      360

gccctagttt cccagccggc aggcggagtg aggaggaagc ggaggcgaga ccgcgctcaa      420

cactggggaa aggaaggagg cgggccctgc gcgcagcatt ttgggaaaga gtggaattct      480

gggtgttagg cccgccattc gcttgactca cgccttcgcc gtagcatctt tcgcagcgga      540

ccgaagagaa gaaaagtagg ccagagccga actctcttcc tgccaagatg tctattggtg      600

tgccgattaa agtactgcat gaggccgagg gccacattgt gacatgtgag acgaacaccg      660

gtgaggtata tcgggggaag ctcattgaag cagaggacaa catgaactgc cagatgtcca      720

acatcacagt cacatacaga gatggccgag tggcacagct ggagcaggta tacatccgtg      780

gcagcaaaat ccgctttctg attttgcctg acatgctgaa gaacgcaccc atgttaaaga      840

gcatgaaaaa taaaaaccaa ggctcagggg ctggccgagg aaaagctgct attctcaagg      900

cccaagtggc cgcaagagga agaggacgtg gaatgggacg tggaaacatc tttcaaaagc      960

gaagataatt ttctaagttg aacagaactt tgtccttttt tctttcaggt tatctgagtt     1020

cattggagtg ggtgcttgtg catatatgct aggtatcttt tgccatcttt ctctttagat     1080

caggggaaat gtttaagcta aataaatctg gggggttttt tgttctgttt tgttttgttt     1140

tctttgagaa aataaggact ttgtgttcat ttgaagtttg ctttggctaa attttgacac     1200

cctgggggat gtcctgggag aatgccagta ctttgaaata gcacagctat tgatgagatt     1260

ttaagctgct gttcctggcc agttgcaggt taagccccag aaaagttcac cttggagaag     1320

ctccgagaac acacagattg tgtctcattc atcttcagac acaggcacat agtgtggcac     1380

tttgttcagt taacatttgt ggagctgtca tcagctcagc tttaacaaca caggtgactc     1440

tttcccttga taaagtcata ggtaattcag gggctgggtg cggcggctca cgcatgtaat     1500

cccagcactt tgggaggcca aggcgggcgg atcacgaggt caggagttcg agaccagcct     1560

ggccaatatg gtgaaacctc gtgtgtacta aaaataaaaa aattagccgg gtgcggtggc     1620

atgtacctgt agtcccagct actcgggagg ctgaggcaga agattcgctt gaacccagga     1680

ggtggacatt gcagtgagca gagatcatgc cactgtactc cagcttgggt gacagagcga     1740

gactgcacct caaaaaaaaa aaa                                             1763


<210> 182
<211> 4469
<212> DNA
<213> Homo sapiens

<400> 182
cgagactcag attgtctgaa ttgagctatc gcaacttaat gctaaaagct ccttaaagct       60

acagatttat gacatagttc cttccaaaat attacatcat aaatcattga gaagattaaa      120

aaaaaacact tgaagaaatt gtagttttaa acatctctgc atatattttg gatagctact      180

aggttacttt aactgtcatt aaggagcaca gacttactga agctttactg gacagaatcc      240

tgggaaatcg atatcattat aaggttatat ttcccagtta gcgggtgaag ggctggagac      300

cttattgcag tcatggcttt cacaaattac agcagtctga atcgagctca gctaaccttt      360

gaatatctgc acacaaattc gtaagtatcc tctaggtgcc actgaggtaa ccagtaactc      420

gttccttgat attatatgga aatcgtttcc ccagaaaatt ttgctttttc actttttgag      480

atgtatccca ctggagtgaa atgtgtcact ggatatcttg agctctgtat tgaagaactg      540

agatcagtga aatacttgtt gctaatccag aagaatctga tttttgttta ttggatcaaa      600

attttctaaa tgcaaacttt agttatttga agtcaatatg ttgagttgtt tcattcaagt      660

gtttatagga atccaacaaa tactgctcta ttggatcgcc aaatgttgga ctattttagt      720

atcaaccgtt tcccctctgt agtgacaacg tcctaaacag ttaggtttat aacaagtgtt      780

tactttctaa caagaaaaca gaagacattt aaatgacaac tttcaagaag aaaattttta      840

ttttttcaga agttggcatt atcttcctgg cagattgctc acatccaata ttatttgtat      900

atgctaaaca ggaaacggca acttgtttat atctctattt agatagtctt tccccaaaat      960

ttccacagaa acatacagtg ttcatggttc ttgagttcat gaaggagtaa tctaatcact     1020

ccaacatggt ctggaatgtt tcaggtttaa tccatatgcc cactctcttg gaggctgtcc     1080

agtagcgtca aaactttagt gttttaatac attcacctgt tacttttgag atgaagttca     1140

cctttcttgg atcacatgca aaggatgttt aggtctgtga agaaaagaat ttctaggccg     1200

ggtgctgtgg ctcacgcctg taatcccagc actttgggag gccgagaacc actcacgaat     1260

tcttgtttgg tgcccttgct gaactggttg ataatgcaag agatgctgat gccaccagaa     1320

tagatattta tgcagaaaga cgagaggacc ttcgaggagg atttatgctt tgctttttgg     1380

atgatggagc aggaatggat ccaagtgatg ctgccagtgt gatccagttt gggaagtcgg     1440

ccaagcgaac acctgagtct actcagattg ggcagtacgg gaatgggtta aaatcgggct     1500

caatgcgcat tgggaaggat tttatcctgt tcaccaagaa ggaagacacc atgacctgcc     1560

tcttcctgtc tcgcacgttt catgaggaag aaggcattga tgaagtgata gtcccactgc     1620

ccacctggaa tgctcggacc cgggaacctg tcacagacaa tgtagagaaa tttgccattg     1680

agacagaact catctataag tactctccat tccgcactga ggaggaagtg atgacccagt     1740

ttatgaagat tcctggggac agcggaacat tggtgatcat cttcaatctc aaactcatgg     1800

ataatggaga gccagaacta gacataatct caaatccaag agatatccag atggcagaga     1860

cgtccccaga gggcacgaag ccagagcggc gctcgttccg tgcctatgcc gctgtgctct     1920

atattgatcc ccggatgagg atcttcatcc atgggcacaa ggtgcagacc aagaggctct     1980

cctgctgcct gtacaagccc aggatgtaca agtacacgtc aagccgtttc aagacccgtg     2040

cggagcagga ggtgaagaaa gcagagcacg tagcaaggat tgctgaagag aaggcgcggg     2100

aggcagagag caaagctcgg acattagaag tacgcctagg tggagacctc acgcgggact     2160

ccagggtgat gttgcgacag gtccagaaca gagccatcac tctgcgcaga gaagccgatg     2220

tcaagaagag gatcaaggag gccaagcagc gagcacttaa agaacctaag gaactgaatt     2280

ttgtttttgg tgtcaacatt gaacaccggg atctggatgg catgttcatc tacaactgta     2340

gccgactgat caaaatgtat gagaaagtgg gcccacagct ggaagggggc atggcatgtg     2400

gcggggttgt tggggttgtt gatgtgccct acctggtcct ggagcctaca cacaacaaac     2460

aggactttgc tgatgccaag gagtaccggc acctgctccg agcaatgggg gagcacctgg     2520

cgcagtattg gaaggatatt gccatcgccc agaggggaat catcaagttc tgggatgagt     2580

ttggctacct ctctgccaac tggaaccagc ccccatccag tgagctgcgt tacaaacgcc     2640

ggagagctat ggaaatcccc accaccatcc agtgcgattt gtgtctgaaa tggagaaccc     2700

tccccttcca gctgagttct gtggaaaaag attaccctga cacctgggtt tgctccatga     2760

accctgatcc tgaacaggac cggtgtgagg cttctgaaca aaagcagaag gttcccctgg     2820

gaacattcag aaaggacatg aagacgcagg aagagaagca gaaacaactg acagagaaaa     2880

ttcgccagca gcaggagaag ctggaggccc ttcagaaaac cacacccatc cgctcccaag     2940

cagacctgaa gaaattgccc ttggaagtga ccaccagacc ttccactgag gaacctgtgc     3000

gtagacctca gcgtcctcgg tcgccccctt tacctgctgt gatcaggaac gcccccagca     3060

gacccccttc tttgccaact cctagaccag ccagccagcc ccgaaaggct cctgtcatca     3120

gcagtacccc aaagctccct gctttggcag cccgggagga ggccagcaca tctaggctgc     3180

tccagccacc tgaggcaccc cgaaagcctg ccaacactct cgtcaagact gcatcccgac     3240

ctgcccctct ggtgcagcaa ctgtcaccat ctttactgcc caactccaag agccctcggg     3300

aggttccttc tcccaaagtc atcaagactc cagtggtgaa gaagacagag tcacccatca     3360

aactctcccc ggctacccct agtcggaagc ggagtgtcgc agtttctgat gaggaagaag     3420

ttgaggagga agctgagagg aggaaggaga ggtgcaagcg gggcagattt gttgtgaagg     3480

aggaaaagaa ggactcgaat gagctctcag acagtgctgg ggaagaggac tcggctgacc     3540

tcaagagagc tcagaaagat aaagggctgc acgtggaggt gcgtgtgaac agggagtggt     3600

acacgggccg tgtcacagcc gtggaggtgg gcaagcatgt ggtgcggtgg aaggtgaagt     3660

ttgactacgt gcccacagac acgacaccaa gagaccgctg ggtggagaaa ggcagtgagg     3720

atgtgcggct gatgaaaccc ccttctccgg aacatcagag ccttgataca caacaggagg     3780

gcggggagga ggaggtgggc cctgtggccc agcaggccat agctgtcgca gagccctcca     3840

cttccgaatg cctccgcatt gagcctgaca ccactgccct gagcaccaat cacgagacca     3900

tcgacctgct tgtccagatc ctccggaatt gtttacggta cttcctgcct ccaagtttcc     3960

ccatctccaa gaagcagctg agtgctatga attcagatga gctaatatct tttcctctga     4020

aggagtactt caagcaatat gaagtagggc tccaaaacct gtgcaattcc taccagagcc     4080

gtgctgactc ccgggccaag gcctccgagg aaagcctgcg cacctccgag aggaagctcc     4140

gcgagacgga ggagaagctg cagaagctga ggaccaacat cgtggcactc ctgcaaaagg     4200

tgcaggagga catagacatc aacacagatg atgagctgga cgcctacatt gaggacctca     4260

tcaccaaggg ggactgaagg caggagagag agcagctccc ctgcccacct gcccctcaac     4320

cctgtagctg cagggggagg ggacttcatt catgggttgg tggtcgcacc ttggtttgac     4380

ttacacggga catttgtgtt tttggaggaa aagataccct gattctttga atcttcctta     4440

agtttataaa tatttatttt ttaaaagaa                                       4469


<210> 183
<211> 4710
<212> DNA
<213> Homo sapiens

<400> 183
gcctgccggt cggcgcccga gctcggagcc gcagccgcag ccggaaaccg ggcccgcgcg       60

gcggccgccg tcccggccaa gccggggccc cgaagccaga gccggagccg ggcgggccgc      120

ggggtcatgg ctgggccgcg gggcgcgctg ctggcctggt gccgccgcca gtgcgagggc      180

taccgcggcg tggagatccg cgacctgagc agctccttcc gggacggcct ggccttctgc      240

gccatcctgc accggcaccg gcccgacctg ctagattttg attcgctttc caaggacaat      300

gtcttcgaga ataaccgttt ggcctttgaa gtggctgaga aggagctggg gatccccgct      360

ctcctggacc ccaatgacat ggtctccatg agcgtccctg actgcctcag catcatgacc      420

tatgtgtccc agtattacaa ccacttctgc agtcctggcc aagctggtgt ctcgccaccc      480

agaaagggcc ttgcaccctg ttccccgccg tctgtagcac ccactccagt ggaaccagaa      540

gatgtggctc agggcgagga gctctcctca ggcagcctgt cagagcaggg caccggccag      600

acccccagca gcacgtgcgc agcctgccag cagcatgtgc acttggtgca gcgctacctg      660

gctgacggca ggctgtacca tcgccactgc ttccggtgtc ggcggtgctc cagcaccctg      720

ctccctgggg cttatgagaa tgggcctgag gagggcacct ttgtgtgtgc agaacactgt      780

gccaggctgg gcccggggac acggtcgggg accaggcctg ggcccttctc acagccaaag      840

cagcagcacc agcagcaact cgcagaagat gccaaggatg ttccaggagg cggccccagc      900

tccagtgctc ctgcaggggc tgaggccgat ggacccaagg ccagccctga ggcccggccg      960

cagatcccta ccaagccccg ggttcctggc aaactacagg agctggccag cccccctgcg     1020

ggccgcccca cccctgcccc caggaaggcc tctgagagca ccaccccagc accccccacg     1080

ccccggcccc gctccagtct gcagcaggag aacctggtgg agcaggctgg cagcagcagc     1140

ctggtgaacg ggagactgca cgaactgcct gtccccaagc cgagggggac accgaagccg     1200

tccgagggga caccagcccc caggaaggac cccccatgga tcacgctggt gcaggcagaa     1260

ccaaagaaga agccagcccc acttccccca agcagcagcc cggggccacc aagccaggac     1320

agcaggcagg tggagaatgg aggcaccgag gaggtggccc agccgagccc aacggccagc     1380

ctggagtcca aaccctataa cccctttgag gaggaggagg aggacaagga ggaagaggct     1440

ccagctgcac ccagcctggc caccagccct gccctgggcc acccggagtc cacacccaag     1500

tccctgcacc cctggtacgg catcacccct accagcagcc ccaagacaaa gaagcgccct     1560

gccccgcgcg cacccagcgc gtccccactg gctctccacg cctcccgcct ctcgcactcg     1620

gagccgccct cggccacacc atcgccagcg ctcagcgtgg agagcctgtc gtctgagagc     1680

gccagccaga ctgcaggtgc agagcttctg gagccgccag ctgtgcccaa gagctcctca     1740

gagcctgctg tccatgcccc tggtacccct ggaaaccctg tcagcctctc taccaactcc     1800

tccctggcct cctctgggga actagtggag cctagagtgg aacaaatgcc tcaagccagc     1860

cctggccttg cccccaggac caggggcagc tcaggtcccc agccagccaa gccctgcagt     1920

ggcgccaccc caacgcctct cttgttggtt ggagacagga gcccggtgcc ttcccctgga     1980

agctcgtccc cacagctgca ggtaaagtcc tcctgcaagg agaatccttt taaccggaag     2040

ccatcacctg cagcgtcccc agccacaaag aaggccacca agggatccaa gccagtgagg     2100

ccacctgccc ctggacacgg ctttccactc atcaaacgca aggtccaggc tgaccagtac     2160

atccctgagg aggacatcca tggagagatg gataccattg agcgccggct ggatgccctg     2220

gagcaccgtg gggtgctgct ggaggagaag ctgcgtggcg gcctgaatga gggccgtgag     2280

gatgacatgc tggtggactg gttcaagctc atccacgaga agcacctact ggtgcggcga     2340

gagtccgagc tcatctatgt cttcaagcag cagaacctgg agcagcgcca ggctgatgtc     2400

gagtatgagc tccggtgcct cctcaataag ccagaaaagg actggacgga ggaggaccgg     2460

gcccgggaga aggtgctgat gcaggagctt gtgaccctca ttgagcagcg caacgctatc     2520

atcaactgcc tggatgagga ccggcagagg gaggaagagg aagacaagat gttggaagcc     2580

atgatcaaga agaaagagtt ccagagggag gctgaacctg agggcaagaa gaaggggaag     2640

ttcaagacca tgaagatgtt gaaactgcta ggaaacaaac gtgatgccaa gagcaagtcc     2700

cccagagaca agagctaaca gcacgagaag ccagttgggg actgccccct cctggagcag     2760

ctcctgggct gtgctctgtt tgaagggggc gccctgctcc cctcagatca gtcaggagga     2820

agatgactaa ggggagggat cctctgggtg atggcctctt cctcctcagg gacctctgac     2880

tgctctgggc caaagaatct cttgtttctt ctccgagccc caggcagcgg tgattcagcc     2940

ctgcccaacc tgattctgat gactgcggat gctgtgacgg acccaagggg caaatagggt     3000

cccagggtcc agggaggggc gcctgctgag cacttccgcc cctcaccctg cccagcccct     3060

gccatgagct ctgggctggg tctccgcctc cagggttctg ctcttccagg caggccagca     3120

agtggcgctg ggccacactg gcttcttcct gccccatccc tggctctgag tctctgtctt     3180

cctgtcctgt gcaggcgccc ttggatctca gtttccctca ctcaggaact ctgtttctga     3240

agtcttcagt taagtttgag tttatgactg agtggcctgt actgtcagac gtgaatgggc     3300

ctgacgggca aatccatccc tctctccctc acagttccag gagcggcttc cctcgtctcc     3360

ccttactcca cagggagcct cccttgccag gaccagggct gcgacggcca tgctggggca     3420

ggtgagtgct ctgttagctg ctcccagtgc tgtccccagg ctgcagttct ggtccctggt     3480

tgtcaggtag gaagggtgca cttgaagcag gtgctcatct cggttcctta acgtttatag     3540

tctgacccct cacttaggct ttcctctgcc accccggtcc agggaagagg ctcgctcccg     3600

cccatggtca tcactggtct gtctgctctg ttgtctgttc tttccctgac tccctcccac     3660

cgaaggcctg atggctactc acccctctgg gatggctatg ggagaggagg agtgatgggg     3720

accgccacct tttctgcagg aaatgtgccc agcagctctt ggtcaaagca ctgttgctat     3780

aagctatctc tgggatgcct ctaggccccc ttccctctac acacctctgg gaaaagatta     3840

cactgtatta actctcgagg agtttcctca ccaataaaca gacaacctca actgccagtg     3900

ccctgcagcc tcgggccaca gcggcagcct tgtttgcctt cccacctgcc tctgccacac     3960

ctggtggctg aacatctctg gtcgcccaga ggccatgttg gggccatcct ccaagaggga     4020

tctctgccct caccgcctgc cactgggcag gatccctttc ctctgcaggg agaggtggct     4080

cctcggccat gcagcccctg gcaggctcct tctaaacatg cctgttgacc tggagctggc     4140

gccaccaact ccagggcctt tccagggcca gacaggtaac acgcatgaac ccgagtgaca     4200

gctctgacgg gctgtttcgg tgtcaggaga caaagctggc aggggcaggg gtgaactgga     4260

ggcaagtcaa gtcacctgtg gcctgtgggg ctgaatgtgg gcccggtgtt gccagatcct     4320

ttgtcataag aagctagaaa tccagatttt atgtgtgtgt aatttgtaaa tgctgaaagc     4380

tagcctgaat tttttttttt tttttttgag acagagtctc gctctgtcgc ccaggctgga     4440

gtgcagtggc gcgatctcag ctcactgcaa gctccgcctc ctgggttcac gccatcctcc     4500

tgcctcggcc tcctgagcag ctgggactac aggcgcatgc tacgacgcct ggctaatttt     4560

ttgtattttt agtagagacg gggtttcacc gtgttaacca ggatggtctc gatctcctga     4620

ccttgtgatc cacccacctt ggcctcccaa agtgctggga ttacaggcgt gagccaccac     4680

gcccggccac tagcctgaat ttcaatcaag                                      4710


<210> 184
<211> 966
<212> DNA
<213> Homo sapiens

<400> 184
cccccaggcc gcgctctagg ggctggactc agggcggttt gaaagatcgg cgcgcaccgc       60

aggagcaacg gttggtcctg cggctgtgat gtcggtgttg aggcccctgg acaagctgcc      120

cggcctgaac acggccacca tcttgctggt gggcacggag gatgctcttc tgcagcagct      180

ggcggactcg atgctcaaag aggactgcgc ctccgagctg aaggtccact tggcaaagtc      240

cctccctttg ccctccagtg tgaatcggcc ccgaattgac ctgatcgtgt ttgtggttaa      300

tcttcacagc aaatacagtc tccagaacac agaggagtcc ctgcgccatg tggatgccag      360

cttcttcttg gggaaggtgt gtttcctcgc cacaggtgct gggcgggaga gccactgcag      420

cattcaccgg cacaccgtgg tgaagctggc ccacacctat caaagccccc tgctctactg      480

tgacctggag gtggaaggct ttagggccac catggcgcag cgcctggtgc gcgtgctgca      540

gatctgtgct ggccacgtgc ccggtgtctc agctctgaac ctgctgtccc tgctgagaag      600

ctctgagggc ccctccctgg aggacctgtg agggtggctg gcccctgggc tgccccttct      660

catggcttcg tgctgactcc ataaacattc tctgttgagg atgtccagtc agggcttgac      720

aggcccaggc tcagcccgcc gtggctggga aggttccctg cagtgccagt gctgcagcag      780

ggagagctgg gcagaagcag cgagggggcc cagctggcga gactgtagcc ccctcccact      840

cccacactca ctcttgcaga gcctgtgtct ttaagcagct ggcgtgttac atctccattt      900

aaggtttcct ttgaacaaaa ggtctgtggc taaaaaaagt ttaaaaatca ctggtctcat      960

tcacca                                                                 966


<210> 185
<211> 1133
<212> DNA
<213> Homo sapiens

<400> 185
gcggcaggag gcgggtgggt caaggtaact ctgggctaca gagtccttgc tgggggttcg       60

gggagcgctt ggaccccggc ttctgggacg cgtcaggaga agggagcact ggctttgctt      120

tcatcaggcc aaagatgcct ttctttggga atacgttcag tccgaagaag acacctcctc      180

ggaagtcggc atctctctcc aacctgcatt ctttggatcg atcaacccgg gaggtggagc      240

tgggcttgga atacggatcc ccgactatga acctggcagg gcaaagcctg aagtttgaaa      300

atggccagtg gatagcagag acaggggtta gtggcggtgt ggaccggagg gaggttcagc      360

gccttcgcag gcggaaccag cagttggagg aagagaacaa tctcttgcgg ctgaaagtgg      420

acatcttatt agacatgctt tcagagtcca ctgctgaatc ccacttaatg gagaaggaac      480

tggatgaact gaggatcagc cggaagagaa aatgaagacc ccagagacat ttattgggga      540

gtaggatgtg gctgagtgct ttttttttgg ccagactagc ggattcagtc ctggaagaga      600

gtatcatata atgagaccca caggcactgg cacccttggg ttggcaatag aaggtgacat      660

ggaatggaga aaaccaagat tccagatggg gatagtaact agaaggtgct tcagatgcac      720

tgcctgcggg tgccagtctg aaaaccagac cgcacagagg cctggggctg ctgatgagct      780

ttttggtgct ctccacacac aagctcgcaa acacacatgt cccagaatag ctctgttggg      840

ttgtgttggg agaagcggct ggagttcatt ctctcacccc cttatgttgg tgtttggcgt      900

gtgacagcag ttctacagag ctctgtgttg gggtcatgga tgagcggctc tcttggctct      960

taaaggcagg cctctctctt cttgccttta aagaatcctc cttcctcaca cctggcctcc     1020

tctggcttca gcttctcagc agcaagcacc agccttccac aacaacacta tatttttatg     1080

ctactttcct gtttgcacta ctactttttt attaaacgat gttaaataat ctc            1133


<210> 186
<211> 3415
<212> DNA
<213> Homo sapiens

<400> 186
atatactcca agaaaaaaac cacaaatgtt tttctgtttt gcctgaatac atgatttaaa       60

caagagattt ccacagaagg gcgctttcat ggaactatat gatcatatgg gcaacattct      120

gttgcagtct accttctgtc tgacggatat gccatcctga aaaaggaaag aagctgaact      180

tcaagttcct ttcatttagc cttgggcttc caccttctct gtggctagaa acaggaccgt      240

ccagaagtca cctgtaactg ccctatcttg caagttctga ttttggcaaa aaaaaaaaaa      300

aaaagccttg acaaggttgg attcacttct ttccctggat tgtgtgtcat ccaactctgc      360

ggccgtcacg atgttctgga agtttgactt gaacaccacg tcccatgttg acaagctgct      420

ggacaaggag catgtgacgc tgcaggagtt aatggatgaa gatgacatct tgcaggagtg      480

taaggctcag aaccagaagc tgctggactt cctgtgcagg cagcagtgca tggaggagct      540

ggtgagcctc atcacacagg atccgcccct ggacatggag gagaaggtcc gcttcaaata      600

tccaaacaca gcctgtgagc ttctgacttg tgatgtgccg cagatcagcg accgcctcgg      660

tggggacgag agcctgctga gcctcctgta cgacttcttg gaccatgagc cgcctctcaa      720

tcctctgctc gccagttttt tcagcaagac cattggcaat ctcattgcaa gaaaaaccga      780

acaggtgatt acgtttttga agaagaagga caagttcatc agcctggtgt tgaagcacat      840

cggcacctca gcgcttatgg acctgctgct gcgcctggtc agctgtgtgg agccagccgg      900

gctccggcag gacgtcctgc actggctgaa tgaagagaag gtcatccaga ggcttgtgga      960

gttgatccac ccgagccagg atgaagatag gcagtcaaat gcttctcaga ctctctgtga     1020

catagttagg ctgggcagag accagggcag tcagctgcaa gaggctctgg agccagaccc     1080

gctcctcaca gcgctggagt cgcaggactg tgtggagcag cttctgaaga acatgtttga     1140

tggagaccgg acggagagct gcctcgtcag tgggactcag gtgttactca ccttgctgga     1200

aaccaggcgg gttgggacag agggcttggt ggactccttt tctcagggac tggaaaggtc     1260

atacgctgtc agcagcagcg tactacacgg catcgagcct cggctgaagg acttccacca     1320

gctcctgctc aacccgccca agaagaaagc gatcctgacc accattggtg tgctggagga     1380

gcccctgggg aatgcccgtc tgcatggcgc ccgcctcatg gcagcactgc tgcacacaaa     1440

cacacccagc atcaaccagg agctctgccg gctcaacacg atggacttac tgctggactt     1500

gttctttaag tacacctgga ataacttttt gcacttccaa gtggaactat gcatagccgc     1560

tattctctcc cacgctgccc gtgaggagag gacagaagcc agcggatccg agagcagggt     1620

ggagcctccg catgagaacg ggaaccggag cctggagact ccccagccgg ccgccagcct     1680

ccctgacaac acaatggtga cccacctgtt ccagaagtgc tgcctggtgc agaggatcct     1740

ggaggcctgg gaagccaacg accacacgca ggcagcgggt ggcatgagac gtgggaacat     1800

gggccacctc acacggatcg ccaacgcggt ggtgcagaac ctggagcggg gccctgtgca     1860

gacgcacatc agcgaggtca tccgagggct ccctgcggac tgccgtggcc gctgggagag     1920

cttcgtggag gagacgctga cggagacgaa ccgcaggaac actgtggacc tggtgagcac     1980

tcaccacctt cactcctcaa gtgaggacga ggacattgag ggtgctttcc ctaacgagct     2040

gtcccttcag caggccttct ctgactacca gatccagcag atgacagcca acttcgtgga     2100

tcagtttggc ttcaatgatg aggagtttgc cgaccaggac gacaacatca atgccccgtt     2160

tgacaggatc gcagagatca acttcaacat cgacgctgac gaggacagtc ccagcgcagc     2220

tctgtttgag gcctgctgca gtgaccgcat ccagcccttt gatgatgatg aggacgagga     2280

catctgggag gacagtgaca ctcgctgtgc tgcccgggtg atggccagac ccaggtttgg     2340

agccccccat gcttcagaga gttgctcaaa gaatggccca gagcgtggag gccaggatgg     2400

gaaggcgagc ttggaagcac acagagatgc acctggggca ggtgccccac cggcccccgg     2460

gaagaaggaa gcgccccctg tggagggtga ctcagaaggc gccatgtgga cggcagtgtt     2520

tgatgagcca gcgaactcaa cgcccacagc cccaggagtg gtgagggacg tgggttccag     2580

tgtgtgggca gctggcacct cagctccaga ggagaaaggc tgggccaagt tcactgactt     2640

ccaacctttc tgctgctccg agtcagggcc caggtgcagc tctccggtgg acacagaatg     2700

cagccatgct gagggcagcc ggagccaagg ccctgagaaa gcctcacagg cctcctactt     2760

tgcagtcagc ccggcttctc catgtgcctg gaacgtgtgt gtcaccagga aggcccccct     2820

gctggcctct gacagtagct cctctggggg ctcccacagc gaggatggcg accagaaggc     2880

agcgagtgcc atggatgcgg tgagcagggg tcccggccgg gaggcccccc cgctgcccac     2940

agtggccagg acagaggagg ctgtcggcag ggtcgggtgt gctgacagcc ggctgttaag     3000

ccctgcctgc cccgcgccaa aggaagtgac tgctgcccca gccgtggctg tgccccccga     3060

ggctactgtg gccatcacca cagcactgag caaggctggc cccgccatac ccaccccagc     3120

agtctcttct gcactggccg tggcggtccc cctagggccc atcatggcag tcacagcagc     3180

cccagccatg gtggccaccc tggggacagt gacaaaggac gggaagacag atgccccgcc     3240

agaaggagct gccttaaatg gcccagtgtg atgctgctgc cgcccggcca cggcccaccc     3300

tggtcaggct gcctccttaa tcgagaaaac tacctggtga tgcaatcttt ttttttttta     3360

atttaattta attttaaaat aaatgctgca ttggtaaagc tggcagttga aacca          3415


<210> 187
<211> 1188
<212> DNA
<213> Homo sapiens

<400> 187
gcaggcgcgg tggtcggacg acagaccgtg tgtttccaaa atggcggcag cgatggatgt       60

ggataccccg agcggcacca acagcggcgc gggcaagaag cgctttgaag tgaaaaagtg      120

gaatgcagta gccctctggg cctgggatat tgtggttgat aactgtgcca tctgcaggaa      180

ccacattatg gatctttgca tagaatgtca agctaaccag gcgtccgcta cttcagaaga      240

gtgtactgtc gcatggggag tctgtaacca tgcttttcac ttccactgca tctctcgctg      300

gctcaaaaca cgacaggtgt gtccattgga caacagagag tgggaattcc aaaagtatgg      360

gcactaggaa aagacttctt ccatcaagct taattgtttt gttattcatt taatgacttt      420

ccctgctgtt acctaattac aaattggatg gaactgtgtt tttttctgct ttgttttttc      480

agtttgctgt ttctgtagcc atattgtatt ctgtgtcaaa taaagtccag ttggattctg      540

gaacggatgc tctctcttgt gtatgtgaac aaagtgaaca taaatgaaga gtctcccctt      600

ccaaggctga aaactcagct tttgaaagtg aaatgtttgt tcatcggggc cagagcaggg      660

ttgtcctctg agcgcatcac ttagtgacga ggaatccaac agctcaaggc agagtgtgga      720

tcaccggctc ccgaaaacag cagtcagccc ttctttctcc tgtgtgacag cagtgggcag      780

ctgaaagagg gaagaatgtg ggattcagtc atcaaaccca gttctgagtc ctggttccac      840

agcttgggta ctgatggcaa tcttggccaa gttgtctctc tactctgaac tttcctcctc      900

tgtactgtgg gcttctgagg actaagtggc atcatgtggg cacagagaga agctttgtaa      960

aatgtaaaac cgctatacaa atgtgacctt tggttgtgta tgacagcagt ccccaacctt     1020

tttgccacca gggattggtt tcatggaaga cgatttttcc atggaccggg ggtggggcgg     1080

gggtgtgctt ggggatggtt ttggaactgt tccacctgag atcatgaggc agtagatgga     1140

ccgcgcaacc tagatccctc acatgcacgg ttcgccaata gggttgaa                  1188


<210> 188
<211> 2687
<212> DNA
<213> Homo sapiens

<400> 188
ggctcggggc gccgaggctt ccgcgcccgc tggttcctcg ctccggggcg gagctcgcga       60

tagcgaccgg gagcagggcg cggggcggga cccaggtccg aggcgaggaa gccggaagcc      120

aggcgcgggg agcctccccc ttcgactgca gcctcgctcc gtgccttctg cgcgcctggg      180

atcccggagc ctgcctaggt tctgtgcgct cccgcccagg ccggtgcccg ccgcccgcct      240

gcgccccagg caggtcccag gcctccggct gctcccggcc gaaggtgggg acaggcagtg      300

gcaggcacca ctagcgaggg cgtttgggaa cccagggtga ccacggcgca gccatgggga      360

ccgcgcttgt gtaccatgag gacatgacgg ccacccggct gctctgggac gaccccgagt      420

gcgagatcga gcgtcctgag cgcctgaccg cagccctgga tcgcctgcgg cagcgcggcc      480

tggaacagag gtgtctgcgg ttgtcagccc gcgaggcctc ggaagaggag ctgggcctgg      540

tgcacagccc agagtatgta tccctggtca gggagaccca ggtcctaggc aaggaggagc      600

tgcaggcgct gtccggacag ttcgacgcca tctacttcca cccgagtacc tttcactgcg      660

cgcggctggc cgcaggggct ggactgcagc tggtggacgc tgtgctcact ggagctgtgc      720

aaaatgggct tgccctggtg aggcctcccg ggcaccatgg ccagagggcg gctgccaacg      780

ggttctgtgt gttcaacaac gtggccatag cagctgcaca tgccaagcag aaacacgggc      840

tacacaggat cctcgtcgtg gactgggatg tgcaccatgg ccaggggatc cagtatctct      900

ttgaggatga ccccagcgtc ctttacttct cctggcaccg ctatgagcat gggcgcttct      960

ggcctttcct gcgagagtca gatgcagacg cagtggggcg gggacagggc ctcggcttca     1020

ctgtcaacct gccctggaac caggttggga tgggaaacgc tgactacgtg gctgccttcc     1080

tgcacctgct gctcccactg gcctttgagt ttgaccctga gctggtgctg gtctcggcag     1140

gatttgactc agccatcggg gaccctgagg ggcaaatgca ggccacgcca gagtgcttcg     1200

cccacctcac acagctgctg caggtgctgg ccggcggccg ggtctgtgcc gtgctggagg     1260

gcggctacca cctggagtca ctggcggagt cagtgtgcat gacagtacag acgctgctgg     1320

gtgacccggc cccacccctg tcagggccaa tggcgccatg tcagagtgcc ctagagtcca     1380

tccagagtgc ccgtgctgcc caggccccgc actggaagag cctccagcag caagatgtga     1440

ccgctgtgcc gatgagcccc agcagccact ccccagaggg gaggcctcca cctctgctgc     1500

ctgggggtcc agtgtgtaag gcagctgcat ctgcaccgag ctccctcctg gaccagccgt     1560

gcctctgccc cgcaccctct gtccgcaccg ctgttgccct gacaacgccg gatatcacat     1620

tggttctgcc ccctgacgtc atccaacagg aagcgtcagc cctgagggag gagacagaag     1680

cctgggccag gccacacgag tccctggccc gggaggaggc cctcactgca cttgggaagc     1740

tcctgtacct cttagatggg atgctggatg ggcaggtgaa cagtggtata gcagccactc     1800

cagcctctgc tgcagcagcc accctggatg tggctgttcg gagaggcctg tcccacggag     1860

cccagaggct gctgtgcgtg gccctgggac agctggaccg gcctccagac ctcgcccatg     1920

acgggaggag tctgtggctg aacatcaggg gcaaggaggc ggctgcccta tccatgttcc     1980

atgtctccac gccactgcca gtgatgaccg gtggtttcct gagctgcatc ttgggcttgg     2040

tgctgcccct ggcctatggc ttccagcctg acctggtgct ggtggcgctg gggcctggcc     2100

atggcctgca gggcccccac gctgcactcc tggctgcaat gcttcggggg ctggcagggg     2160

gccgagtcct ggccctcctg gaggagaact ccacacccca gctagcaggg atcctggccc     2220

gggtgctgaa tggagaggca cctcctagcc taggcccttc ctctgtggcc tccccagagg     2280

acgtccaggc cctgatgtac ctgagagggc agctggagcc tcagtggaag atgttgcagt     2340

gccatcctca cctggtggct tgaaatcggc caaggtggga gcatttacac cgcagaaatg     2400

acaccgcacg ccagcgcccc gcggccgcga tccggacccc aagcccacgg ctccctcgac     2460

tctggggcac ggaaccccgc ccactcccaa tccccgcgcc ccgccctctc ccacccgtgc     2520

ttcccccgct ccacccctca cctcacctcg cccccgcccc acccatcgcg ccccggcccg     2580

tcccatcgag gcccatgcaa cccacgctcg gtcccgttcc ggcccctgcg ccccgctgcg     2640

cttcgctccc cgcccttgcg ccgttagtaa acatcgctca aacgaaa                   2687


<210> 189
<211> 2271
<212> DNA
<213> Homo sapiens

<400> 189
aatcccggcg tggacagcgc gaggagaaag atggcggcga tggcggtcgg gggtgctggt       60

gggagccgcg tgtccagcgg gagggacctg aattgcgtcc ccgaaatagc tgacacacta      120

ggggctgtgg ccaagcaggg gtgagggccg gacctccacg agcggaatgc ggggtccgaa      180

ctcggggacg gagaagggca gactagtcat cccggagaag caggggtttg atttcctctg      240

catgcctgtc ttccatccgc gtttcaagag ggagttcatt caggaacctg ctaagaatcg      300

gcccggtccc cagacacgat cagacctact gctgtcagga agggctttcc tgctgcccct      360

taatcaggaa gataacacca acctggccag agttttgacc aaccacatcc acactggcca      420

tcactcttcc atgttctgga tgcgggtacc cttggtggca ccagaggacc tgagagatga      480

tataattgag aatgcaccaa ctacacacac agaggagtac agtggggagg agaaaacgtg      540

gatgtggtgg cacaacttcc ggactttgtg tgactatagt aagaggattg cagtggctct      600

tgaaattggg gctgacctcc catctaatca tgtcattgat cgctggcttg gggagcccat      660

caaagcagcc attctcccca ctagcatttt cctgaccaat aagaagggat ttcctgttct      720

ttctaagatg caccagaggc tcatcttccg gctcctcaag ttggaggtgc agttcatcat      780

cacaggcacc aaccaccact cagagaagga gttctgctcc tacctccaat acctggaata      840

cttaagccag aaccgtcctc cacctaatgc ctatgaactc tttgccaagg gctatgaaga      900

ctatctgcag tccccgcttc agccactgat ggacaatctg gaatctcaga catatgaagt      960

gtttgaaaag gaccccatca aatactctca gtaccagcag gccatctata aatgtctgct     1020

agaccgagta ccagaagagg agaaggatac caatgtccag gtactgatgg tgctgggagc     1080

aggacgggga cccctggtga acgcttccct gcgggcagcc aagcaggccg accggcggat     1140

aaagctgtat gctgtggaga aaaacccaaa tgccgtggtg acgctagaga actggcagtt     1200

tgaagaatgg ggaagccaag tgaccgtagt ctcatcagac atgagggaat gggtggctcc     1260

agagaaagca gacatcattg tcagtgagct tctgggctca tttgctgaca atgaattgtc     1320

gcctgagtgc ctggatggag cccagcactt cctaaaagat gatggtgtga gcatccccgg     1380

ggagtacact tcctttctgg ctcccatctc ttcctccaag ctgtacaatg aggtccgagc     1440

ctgtagggag aaggaccgtg accctgaggc ccagtttgag atgccttatg tggtacggct     1500

gcacaacttc caccagctct ctgcacccca gccctgtttc accttcagcc atcccaacag     1560

agatcctatg attgacaaca accgctattg caccttggaa tttcctgtgg aggtgaacac     1620

agtactacat ggctttgccg gctactttga gactgtgctt tatcaggaca tcactctgag     1680

tatccgtcca gagactcact ctcctgggat gttctcatgg tttcccatcc tcttccctat     1740

taagcagccc ataacggtac gtgaaggcca aaccatctgt gtgcgtttct ggcgatgcag     1800

caattccaag aaggtgtggt atgagtgggc tgtgacagca ccagtctgtt ctgctattca     1860

taaccccaca ggccgctcat ataccattgg cctctagccc tgcgtgccaa gtgtccagag     1920

ccttggaagc agcttcaggt tctgctcctg tagtacagaa ggtgcagtac atctatgggc     1980

tgtgattccc cttgcccatc agagaggagc atttcaatct gctttcctgc cttacatcaa     2040

ggtgggcaag ggattataat taattgcagg gctcaagcca ccaatctatg aagacctcag     2100

gccagggggt gaggaattag tgctggattt gaagctacgc actcagcctc aagaactccc     2160

tggaatatcc ctgagaacat ggggtttgaa cggattttca gcctttttct gttcttgttt     2220

tgatggtttt gtgtaagagg aaatacaaat aaagttatag ccctttactg c              2271


<210> 190
<211> 1420
<212> DNA
<213> Homo sapiens

<400> 190
aagcgggtct ggagcgggcg agacggccag ggccggcgag cgcagtgcag cgccgcgcgg       60

tgcgggcggc cgagtggggg cgtcatggag gatgagcgga gcttttcgga tatctgcggc      120

ggccgcctgg cgctgcagcg ccgctactac tccccgtcct gccgggaatt ctgcctcagc      180

tgccctcggc tctcgctgcg ttcgctcacc gctgtcacct gcacggtgtg gctggcggcc      240

tacggactct tcaccctctg cgagaacagc atgatcctct ctgctgccat cttcatcacc      300

ctcttaggtc tgcttggtta tctccatttt gtgaagattg atcaggagac tctgttaatc      360

attgattccc ttggcattca gatgacttca tcttatgctt caggcaaaga aagcactacc      420

ttcatagaaa tgggcaaggt caaggatatt gtcatcaatg aggccattta catgcagaag      480

gtgatttact acctctgcat cttattgaaa gatccagtgg aaccacatgg gatatcccaa      540

gtagtacccg tcttccagag tgccaagccc cggctggact gcttgattga agtatacagg      600

agctgccagg agatcctggc acaccagaaa gccacatcaa caagcccatg agccccagcg      660

ttcagaaggc cagcattgtc ttccatggga gatgactctt aagccatagg ggctggtttt      720

ccgtactcca aaccatcagg tggacacagt cctaggaacc attatggatg tagtgcatct      780

tagagccata gagcaggtga ctggaaatct aactcagtat atttccgtgt attatagtgt      840

tttccttgta aggttttgcc tactttacca aaggagggga gaccttaaga attttgacac      900

agtatgtcaa aagtaatgtc agcaaagaac actttcggaa attgctaagc atgttcaggt      960

ttactttgtt gatgtttgtg aagcaaaaca atgggaaact gacatcagat gtcttgagaa     1020

agctatattt tccaatagta ccccttgtgt aaagttacga aaaaaacaag cccttcagta     1080

ctggttagca ggaagaaatg tcctacaaaa gacgagtctg tcaacctagt gcctgtgttc     1140

tgtacagggc ttatttattt actgttaata aacagatctt ccaaaacaca cagttacctg     1200

gttcacagat agctgctttt tattgacaaa caagatcata gtatttcagt catggtgtca     1260

agcacattaa tacttttctg ttactcagca ttttttttta tatcagttca aaagctactt     1320

ttgccaagaa ggatgagaca aaaggccaga cagaaattgg actttggttt tcagacatgg     1380

gactctcatg ttaacaaaga ataaataagc aaatattgaa                           1420


<210> 191
<211> 1402
<212> DNA
<213> Homo sapiens

<400> 191
ggaagttaag gaggggaggg ggtggaggga aaagcaagcc aggaggtgct tgcggccgct       60

tctagtagtt tccaggcgct gccgggcggc tggcactaag cggtcctgag gctgtggcta      120

cggctgctcc ggagctggtg gcgccgcgat aggagagccg atggccaagt ggggtgaggg      180

agacccacgc tggatcgtgg aggagcgggc ggacgccacc aacgtcaaca actggcactg      240

gacggagaga gatgcttcaa attggtccac ggataagctg aaaacactgt tcctggcagt      300

gcaggttcaa aatgaagaag gcaagtgtga ggtgacggaa gtgagtaagc ttgatggaga      360

ggcatccatt aacaatcgca aagggaaact tatcttcttt tatgaatgga gcgtcaaact      420

aaactggaca ggtacttcta agtcaggagt acaatacaaa ggacatgtgg agatccccaa      480

tttgtctgat gaaaacagcg tggatgaagt ggagattagt gtgagccttg ccaaagatga      540

gcctgacaca aatctcgtgg ccttaatgaa ggaagaaggg gtgaaacttc taagagaagc      600

aatgggaatt tacatcagca ccctcaaaac agagttcacc cagggcatga tcttacctac      660

aatgaatgga gagtcagtag acccagtggg gcagccagca ctgaaaactg aggagcgcaa      720

ggctaagcct gctccttcaa aaacccaggc cagacctgtt ggagtcaaaa tccccacttg      780

taagatcact cttaaggaaa ccttcctgac gtcaccagag gagctctata gagtgtttac      840

cacccaagag ctggtgcagg cctttaccca tgctcctgca acattagaag cagacagagg      900

tggaaagttc cacatggtag atggcaacgt ctctggggaa tttactgatc tggtccctga      960

gaaacatatt gtgatgaagt ggaggtttaa atcttggcca gagggacact ttgccaccat     1020

caccttgacc ttcatcgaca agaacggaga gactgagctg tgcatggaag gtcgaggcat     1080

ccctgctcct gaggaagagc ggacgcgaca gggctggcag cggtactact ttgagggcat     1140

taaacagacc tttggctatg gcgcacgctt attttagggc cagcggcagg ggactccagc     1200

ctgctggaca cttcagtcca gctctctcct gactggggct tgcgactcac aggattgcat     1260

cgtcccagct gctaacttgg ggccggggcc cctcccttcc acatatacct tgggtttgtg     1320

catgttttct gctgggtggg ttcagagggc aatttctctt ttatgtgtac atatgctaaa     1380

taaacataat ttaaaaaaca tg                                              1402


<210> 192
<211> 3859
<212> DNA
<213> Homo sapiens

<400> 192
aggaagtaga agggagcgag agccccagag cgcggcggca gcggcggcct ggcccttcca       60

gagggccaga gccagggaca tgcgggcgcc cgggactccg cgttccgcgc ggcccggcgc      120

ctgagcgcct ccgttccccg tcccggagct gccggcggca tgatccgaca cgccggggcg      180

cccgcgcgcg gggaccccac gggtccggtt ccagttgttg gcaaaggaga ggaagaggaa      240

gaggaagatg gcatgcggct ttgtctgcca gccaacccga aaaactgcct tcctcaccgc      300

cggggcatca gcatcctgga gaagctcatc aaaacatgcc cggtgtggct gcagctgagt      360

ctgggccagg cagaggtggc caggatcctg caccgggtgg tggctgggat gttcctggtt      420

cgccgggaca gcagctcgaa gcagctggtg ctctgtgtcc actttccttc tctgaacgaa      480

agctcggccg aggtgctcga atacaccatt aaggaagaaa agtcgatatt gtacctggaa      540

ggctcggctc ttgtgtttga ggacatcttc agattgattg cgttctactg tgtcagtaga      600

gacttactgc ccttcacact gcggctaccc caggccatcc ttgaggccag cagcttcacg      660

gaccttgaga ccatcgccaa cctgggtctg ggtttctggg actcctcgct gaatcctcca      720

caagaaagag ggaagccagc agagccccca agagaccggg cccccggatt ccccctagtc      780

tccagcctca ggcccacagc ccatgacgca aactgtgcct gtgaaatcga gctgtcggta      840

ggaaatgacc gcctgtggtt tgtgaatcct attttcatcg aggactgcag cagcgccctg      900

cccaccgacc agccacctct tggaaattgc cctgcacgcc ctttgccgcc cacctctgat      960

gccacctcac ccacctccag gtgggcccca cgccgcccac caccccctcc cccagtgctg     1020

cccctgcagc cctgcagccc agcccagccc cctgtgctcc ctgctcttgc ccccgcccct     1080

gcctgtcctt tgcccacctc tcccccagtg cctgcccccc acgtcacacc ccatgcccca     1140

ggtcccccag accatccgaa ccagccgccc atgatgacct gcgagagact cccatgcccc     1200

actgcaggcc tgggccccct cagggaggaa gcgatgaagc caggggcagc ctccagtccc     1260

ttgcagcagg tccccgcccc gccactgcct gcgaagaaga accttcccac tgcccctccc     1320

agacgccgcg tttccgagag ggtgtcctta gaagaccaaa gtccggggat ggcggcagag     1380

ggggaccagc tcagcctgcc tccccaaggg acctcagacg gccctgagga cacgccccgg     1440

gagagcacgg agcaaggcca ggacacagag gtgaaagcca gcgatcctca cagcatgcca     1500

gagctgccca ggacagccaa acaaccccca gtcccgcccc ccaggaaaaa acggatctct     1560

cgacaactgg cctcgaccct cccagctccc ttagagaacg ctgagctctg cacacaggcg     1620

atggccttgg agacacccac gccgggtcca cccagagagg gccaaagccc tgcttctcag     1680

gctgggactc agcaccctcc tgcccaggcc actgcccatt cccagagctc tccagagttc     1740

aagggctccc tggcctccct ctcagacagc ttgggggtgt ctgtcatggc caccgaccag     1800

gactcctact ccaccagcag cacggaggag gagctggagc agttcagcag ccccagcgtg     1860

aagaagaagc cctccatgat cctgggcaag gctcggcacc ggctgagctt tgccagtttc     1920

agcagcatgt tccacgcttt cctctccaac aaccgcaagc tgtacaagaa ggtggtggag     1980

ctggcgcagg acaagggctc gtactttggc agcctggtgc aggactacaa ggtgtacagc     2040

ctggagatga tggcgcgcca gacctccagc acggagatgc tgcaggagat tcgcaccatg     2100

atgacccagc tcaagagcta cctgctgcag agcaccgagc tcaaggccct ggtggacccc     2160

gccctgcact ccgaggagga gctcgaagca attgtagagt ctgccttgta caaatgtgtc     2220

ctgaagcccc tgaaggaagc catcaactca tgcctgcatc agatccacag caaggatggt     2280

tcgctgcagc agctcaagga gaaccagtta gtgatcctgg ccaccaccac cactgaccta     2340

ggtgtgacca ccagcgtgcc ggaggtgccc atgatggaga agatcctgca gaagttcacc     2400

agcatgcaca aggcctactc acctgagaag aagatctcca tcctgctcaa gacctgcaaa     2460

ctcatctacg actccatggc cctcggcaac ccagggaagc cctatggggc ggatgacttc     2520

ctgcctgtgc tcatgtatgt gctggcccgc agcaacctca cggagatgct tctcaatgtg     2580

gagtacatga tggagctcat ggaccccgcc ctgcagctgg gggagggttc ctactatctg     2640

accaccacct acggggccct ggagcacatc aagagctacg acaagatcac ggtgacccgg     2700

cagctgagtg tggaggtgca ggactccatc caccgctggg agcgccggcg tactctcaac     2760

aaggcccggg cctcccgctc ctccgtacag gacttcatct gcgtgtcgta cctggagccc     2820

gagcagcagg cgcggacgct ggcgtcgcgg gcggacaccc aggcccaggc gctgtgcgcg     2880

cagtgcgcgg agaagttcgc ggtggagcgg ccgcaggcgc accggctgtt cgtgctggtg     2940

gacgggcgct gcttccagct ggcggacgac gcgctgccgc actgcatcaa gggctacctg     3000

ctgcgcagcg agcccaagcg cgacttccac tttgtctacc ggcccctgga cggtggtggc     3060

ggcggcggcg gcgggagccc gccctgcctg gtggtgcggg agcccaactt cctgtgaggc     3120

cctcccgggg cgcctcccct cacccccagg cgcacgtctg gccccgcctc tggctgcgca     3180

ctcccgaccg cgacgtccac gcagcagagg gacatgggcc attccatgac gtgcccaggc     3240

caacgtcgca ggacagttgt gaaaataaca tgacgctcgt ccaaggccac ttcctgaggg     3300

caagtcctaa tagccctgag acaccgagac ggcatgttct tcattagacg gaaagggaaa     3360

ctgaggctca ggagagaggc gctccaggcc gctgcagcca acaaaccggc gccctcttca     3420

cacgtagctc ctcaggccat tccccatgag tcccccacac ccaccccatc ctcggtcttt     3480

gcaaagaagg gcccgagctt agtttcccca ggactggcct aggaaggagc accggccaca     3540

gctgctcccc gtgccactca gggtggaccc agcatctcag gagcacctca gggtgtcggt     3600

taagagacag gcctccaccc ctgcaccaga gcctgctctt agctcccggt gcccccagac     3660

cccgcagctc tgtgcccggc aagaagcagc tagacacacg ccagggcgcc aagcacggcc     3720

agctccgcgg acccatggac aagcccagcc ccgcctcagg gaaaacaggg cctttcccta     3780

caggacacgc cccagagctg tggcagattg caggagccat cgtgtgggga gaatttaata     3840

aaagcccttt tgaaaatga                                                  3859


<210> 193
<211> 1606
<212> DNA
<213> Homo sapiens

<400> 193
gctgcgtttg gtcagttgca ccttctgggt cactggtagc cgcgggagcc gggtggggcc       60

taggcgatga tccggcatta aggagctggg atcatcctcc gtctcaggtg gtttggggaa      120

agtgtagggg caaccaaaga tcatcggctt gactaggccc tttgccctga acctcatgaa      180

gaaatgatag gaggcagaca tatgtgccta aaaagagcgt tgagctcaga gaagagcaac      240

tcggagtttt gggggtgtgc tttgatttgt gtacatcaat ggcagaatca tccagcgaat      300

cagatcactt ccgctgtcgt gaccgattga gtccatgggc tgccagatca acgcacaggg      360

gaactcgaag tcttcctaca gtagaagtta ccgagaaggt caacactata acaagtactt      420

tacaggatac cagtcggaac ctgcgacaag tggaccagat gcttggacga taccgagaat      480

acagtaatgg acaggcgggt gcgatagaac atttaaaaga aagcttggaa caatcaatcg      540

accaactccg gagtcaacgt ttattgagaa actcaggagg gagaagtatt tctgttacaa      600

gtttgagtgc aagtgacctt gatggtggca ctgggtcaga gctccatcat tttccaccta      660

cctcacctct caaggactat ggggatccac agggtattaa acgaatgaga tcaagaactg      720

gtgtccggtt tgttcaagag actgatgata tgactcagct tcatggtttt catcagtctc      780

ttcgagacct cagcagtgaa caaattcgcc ttggagatga tttcaacagg gagctttcca      840

gaaggagccg gtcagatgcc gaaacaaaaa gggctttgga agaattgact gaaaaactta      900

atgaagccca gaaacaagaa gtggtttcag atcgggtgga gcggcggctt caggaactgg      960

agagagagat gcgcacagaa agggagctgg tggaaagacg ccaggatcaa ctgggactca     1020

tgtccctgca gctacaggag gcactaaaga aacaagaagc taaagcagat gagcatgagg     1080

gggcaataaa aaataagcta agacaaactg aaactgagaa gaatcaactt gaacaggaat     1140

tggagctatc tcgaaggtta ttgaatcaat cagaaggcag ccgagaaaca cttttgcatc     1200

aggtagaaga actgcgtaca caacttacga aagcagaagg tgatcgaaag ggtttacagc     1260

atcaagtatc tcagatttcc aagcaacagt caaactatca ggatgaacaa ggggaggact     1320

ggagatttag gagaggggtt gagcgggaaa aacaggacct ggagaagcaa atgtcagatt     1380

tgagagtgca gctgaacttc agcgcaatgg catctgagtt agaggaagtg aaacggtgca     1440

tggagagaaa agacaaggag aaagcacatt tggcatcaca agtagagcac atcaatagaa     1500

aatgtctttt aaatttggtt caagatttgg attgtaaaga taatgaaata ttgacatact     1560

ctttacaaag ccctctacat gtttaataaa gacttacttg aaattg                    1606


<210> 194
<211> 2495
<212> DNA
<213> Homo sapiens

<400> 194
cctggtcctg ccgctgcgcc cgcccgccat ggtgtcccgg gaccaggctc acctgggccc       60

caagtatgtg ggcctctggg acttcaagtc ccggacggac gaggagctga gcttccgcgc      120

gggggacgtc ttccacgtgg ccaggaagga ggagcagtgg tggtgggcca cgctgctgga      180

cgaggcgggt ggggccgtgg cccagggcta tgtgccccac aactacctgg ccgagaggga      240

gacggtggag tcggaaccgt ggttctttgg ctgcatctcc cgctcggaag ctgtgcgtcg      300

gctgcaggcc gagggcaacg ccacgggcgc cttcctgatc agggtcagcg agaagccgag      360

tgccgactac gtcctgtcgg tgcgggacac gcaggctgtg cggcactaca agatctggcg      420

gcgtgccggg ggccggctgc acctgaacga ggcggtgtcc ttcctcagcc tgcccgagct      480

tgtgaactac cacagggccc agagcctgtc ccacggcctg cggctggccg cgccctgccg      540

gaagcacgag cctgagcccc tgccccattg ggatgactgg gagaggccga gggaggagtt      600

cacgctctgc aggaagctgg ggtccggcta ctttggggag gtcttcgagg ggctctggaa      660

agaccgggtc caggtggcca ttaaggtgat ttctcgagac aacctcctgc accagcagat      720

gctgcagtcg gagatccagg ccatgaagaa gctgcggcac aaacacatcc tggcgctgta      780

cgccgtggtg tccgtggggg accccgtgta catcatcacg gagctcatgg ccaagggcag      840

cctgctggag ctgctccgcg actctgatga gaaagtcctg cccgtttcgg agctgctgga      900

catcgcctgg caggtggctg agggcatgtg ttacctggag tcgcagaatt acatccaccg      960

ggacctggcc gccaggaaca tcctcgtcgg ggaaaacacc ctctgcaaag ttggggactt     1020

cgggttagcc aggcttatca aggaggacgt ctacctctcc catgaccaca atatccccta     1080

caagtggacg gcccctgaag cgctctcccg aggccattac tccaccaaat ccgacgtctg     1140

gtcctttggg attctcctgc atgagatgtt cagcaggggt caggtgccct acccaggcat     1200

gtccaaccat gaggccttcc tgagggtgga cgccggctac cgcatgccct gccctctgga     1260

gtgcccgccc agcgtgcaca agctgatgct gacatgctgg tgcagggacc ccgagcagag     1320

accctgcttc aaggccctgc gggagaggct ctccagcttc accagctacg agaacccgac     1380

ctgagctgct gtggagcggg catggccggg ccctgctgag gaggggcctg ggcagagggc     1440

ctggacctgg gatcaaggcc cacgcgcttc cctggggttt actgaggtga tgggtgcagg     1500

aaaggttcac aaatgtggag tgtctgcgtc caatacacgc gtgtgctcct ctccttactc     1560

catcgtgtgt gccttgggtc tcagctgctg acacgcagcc tgctctggag cctgcagatg     1620

agatccggga gactgacacg aagccagcag aggtcagagg ggactctgac cacagcccgc     1680

tctctggctg tctgtctgca gtgcccggct gagggtggga ggcaaacacg ccttgttcct     1740

gctcttccca gttcagcttg gtgggagaaa gtcattcgcg tggctcggga cgctcatgta     1800

aatttggttt tggtgctcaa gggttctttc ctcccagggg caggtgtttc tttcctgttt     1860

gtcttgtgtc ttgagagctt ggccttatga ccagtgagaa ctctctccct ggtctctgcc     1920

agcccaagca tcactgcccg aggcgccagc tcagtttcac cgtccacgtc cacaaggggc     1980

ttttcccacc ttcacctttg tcgctgggtc agtgctggaa agcgcccctc actcctgcgc     2040

tgacaagggc ccttctctac tgtctgtggg gtggttccgg gctggggggg ctgcctcctt     2100

tgcacctgat tttgaaggtg tctctttcat ccatggttaa gtcataaaaa gcttattggt     2160

tttggttttg actcacctga aagttttttt ggtttaaaag aagaataggc ggggcacggt     2220

ggctcatgcc tgtaatccca gcactttggg aggctgaggc aggtggatca cgaggtcagg     2280

agatcgacac catcctggct aacacggtga aaccccgtct ctactaaaaa atacaaaaaa     2340

ttagctgggt gtggtggtgg gggtgggcgc ctgtagtccc agctacgtgg gaggctgagg     2400

cagcagactg gtgtgaaccc gggaggtgga gcttgcagtg agccgagatc gcgccactgc     2460

actccagcct gggcgacaga gcgagactcc atctc                                2495


<210> 195
<211> 1374
<212> DNA
<213> Homo sapiens

<400> 195
ctctgaggtg ccactgcccc cgggagcact ggccacgctg agttctagct gttctcttgg       60

agtggctttg cacagaagca gcccggcgtc cagagggcca ggtgaatctt cacttcctgc      120

cttctctggg gtggctctgt tgcccccagc ctgtaaggct ggcctcccct acaatctcag      180

ccgacaagag ggacatctga cgtgcctctc aatccctgac atcaagacgg ccttcagcga      240

ctgcaccagc aagatcggca ggcgagattg cctgacccag gcctgctcgg ccctcacagg      300

caaaggggtg cgcgagggca tcgagtggat ggtgaagtgt gtcgtgcgga atgtgcaccg      360

gccgccgcgg cagagggaca tcacgtaggc gcagccgcgc tgccgtcggg acggctggtc      420

ccctggtgct ggaggagtgg cctcctgttg gctcccatgc tgctgatctg gggggtgggt      480

ttgctttgct ttggggttct tctatttact ttgttttctc gaagacaaac tttcctctat      540

gtctggaaaa gcgtaggcat ccggaggctt tggaggggag tctggcagcc cggctggccc      600

aggccctgca gcggcagcct ttccacaggg cgcagcggcg gcctttcgag gccctttctg      660

gggggtctga gggagacctg gttgggaatt ggggctccag tgctcaggct ggcttgggct      720

gcatgaggac agccctgtgg gaccctcggg agaccccgtg gctgtctccg ccccatcgag      780

gaggaggccc gtcagccatg gctgccatct ggcttctgcc ctgtgacccc gtgaccccgt      840

gaccccgaag tggtctgggg ctgatcttgc cttgaggaag acccaggcca tgttcccaaa      900

ggccagcggg ggccctggat tgtgatgcag cctcgggaca gggctgaggc ctgcggggga      960

agacctatac cccacgcctg ggcctggctt cacctcaccc taatcccccg ggagggagct     1020

gactgatgca aaaagctgag ggggcctgct gggagtggct gtttttatgc cccagccccg     1080

caagttgggg agtgtttgtg ggggtccaga gccctccccc agccaggaga gaacctcccg     1140

gaggggttct ctgtggggcc ctgtgtcccc tgctcgggag taaggctggt cctggggtcc     1200

tccctgcacg gaccccactg ggcctgccga gtgctgtgtt cttcctcagt ctggctgtgg     1260

gcaggagcgg cctgcccagt gtcacccagg gtgagtgcaa aataaagacg gcgagtgtgg     1320

ctctgtccat cccttccctc ctggagggtg gaggctcctg gctgttggac acgg           1374


<210> 196
<211> 2429
<212> DNA
<213> Homo sapiens

<400> 196
aaagcagcca atgggagagc cgaggcgggg aggtgcggcc aatggcgcgg gcctgtttga       60

ttcaaaggtt gcctataaag cgggactgca cgccggtttt tgtccgaggg ctgtcgagtc      120

cgagcgccgc catggctctg ctgtccgagg gcctggacga ggtgcccgcc gcctgcctgt      180

cgccgtgcgg gccgcccaac ccgaccgagc tgttcagcga gtcacggcgc ctggctctgg      240

aggagctggt ggcgggcggc cccgaagcct tcgcggcctt cctgcgacgc gagcgcctgg      300

ctcgtttcct gaaccccgat gaggtgcacg ccattctgcg cgcggcggag aggccgggag      360

aggagggcgc ggcggcggcg gcggcggccg aggactcgtt cggctcctcg cacgactgct      420

cttcgggcac ctacttcccc gagcagtcgg acctggagcc accgctgttg gagcttggct      480

ggcccgcctt ctaccagggc gcctaccgcg gcgccacgcg tgtcgagacg cacttccagc      540

cccgcggcgc tggcgaaggt ggcccctacg gctgcaagga cgctctgcgc cagcagctcc      600

gctcggcgcg agaggtgatt gcagtggtca tggacgtgtt cacagacatc gacatcttca      660

gagacctgca agaaatatgc aggaaacagg gagttgctgt gtatatcctt ctggaccagg      720

ctctcctctc tcaatttctg gatatgtgca tggatctgaa agttcatcct gaacaggaaa      780

agttaatgac agttcggact atcacaggaa atatctacta tgcaaggtca ggaactaaga      840

ttattgggaa ggttcacgaa aagttcacgt tgattgatgg catccgcgtg gcaacaggct      900

cctacagttt tacatggacg gatggcaaat taaacagcag taacttggta attctgtctg      960

gccaagtggt tgaacacttt gatctggagt tccgaatcct gtatgcccag tccaagccca     1020

tcagccccaa actcctgtct cacttccaga gcagcaacaa gtttgatcac ctcaccaacc     1080

gaaaaccaca gtccaaggag ctcaccctgg gcaacctgct gcggatgcgg ctggctaggc     1140

tgtcaagtac tcccaggaag gcggacctgg acccagagat gcccgcagag ggcaaggcag     1200

agcgcaagcc ccatgactgt gagtcctcta ctgttagtga ggaagactac ttcagcagcc     1260

acagggacga gctccagagc agaaaggcca ttgacgctgc cactcaaaca gagccaggag     1320

aggagatgcc agggctgagt gtgagtgagg tgggaacaca aaccagcatc accacagcat     1380

gtgctggtac ccagactgca gtcatcacca ggatagcaag ctctcaaacc acgatttggt     1440

ccagatcgac cactactcag actgacatgg atgagaacat tctctttcct cgaggaactc     1500

aatctacaga agggtcacca gtctcaaaaa tgtctgtatc gagatcttcc agtttgaagt     1560

cttcctcctc tgtgtcttcc caaggctctg tggcaagctc cactggttct cccgcttcca     1620

tcagaaccac tgacttccac aatcctggct atcccaagta cctgggcacc ccccacctgg     1680

aactgtactt gagtgactca cttagaaact tgaacaaaga gcggcaattc cacttcgctg     1740

gtatcaggtc ccggctcaac cacatgctgg ctatgctgtc aaggagaaca ctctttactg     1800

aaaaccacct tggccttcat tctggcaatt tcagcagagt taatttgctt gctgttagag     1860

atgtagcact ttatccttcc tatcagtaac tgctccgtgt tcagactcct ggtttcttcc     1920

aggcttacag tggacatcat cagcttcctg ctttaaaaaa tatcttatgt ccctaattgc     1980

ctttctttta cctgactttg tcacctttgt tgtctttgaa ttctttaggc tgcatattat     2040

tttacatgct ttgttttgtc atgtatatac caggtattgg ttttatggtt taaacactat     2100

ggatacaggg gtttgttttg cacaatttta atagtcatgc actacataat gatgttttgg     2160

tcaatgacag accacgtata tgttggcagt ctcataagat tataatactg tatttttact     2220

ataccttttc tgtgtttaga tacaaatacc attatgttac agttgcctac agtattcagt     2280

gcagtaacat gatgtacagg tttgtagcct gttttgcatt tttcttaggt tgtatgctct     2340

tctgttttaa aggtttgaat caccagcatt tttgtgatca aaatcctatt tagaaaaaat     2400

aaaactactt tctgtttatc tctttagaa                                       2429


<210> 197
<211> 6938
<212> DNA
<213> Homo sapiens

<400> 197
tggctgctgg gtgccgcacg ccttcccatc ctcctcctct cccctccccc atccctcccc       60

gccccctcgg ccgctccgct ccctggcgtg actcggcact gagagtcccg ggagaagact      120

cggcggtcgc cacctcttct gtccaggcct cggccttcct gagcatctct ccttcctctc      180

ccagatcgtc ttctccttca gtttcaaagc cagtggcgtc gcggccaccc tgccgggctc      240

tctgtgagga tggtgggggt gaagcccgtc gggagcgacc cggatttcca gccagagctg      300

agcggcgcgg gctccagact cgccgtggtc aagttcacca tgagagggtg tgggccatgt      360

ttgaggattg ccccagcatt cagttctatg agtaataaat atccacaggc tgttttcttg      420

gaagtcgatg tacatcagtg tcagggaaca gctgccacca acaatatatc agcaacacct      480

acatttttgt tttttcgaaa caaagtgaga attgatcaat atcaaggagc agatgctgtg      540

ggattagaag aaaaaatcaa gcagcactta gaaaatgacc ctggaagcaa tgaggacaca      600

gatattccaa aaggctatat ggatttaatg ccttttatta acaaagctgg ttgtgaatgt      660

cttaatgaaa gtgatgagca tggatttgac aactgtttac gaaaagacac aaccttcttg      720

gaatctgact gtgatgaaca gctgcttatt actgtggcat tcaatcaacc tgttaagctt      780

tattccatga aatttcaagg gccagataat ggtcagggcc ctaaatatgt aaaaattttt      840

atcaacctac cccgatctat ggattttgaa gaggcagaaa gaagtgaacc aactcaagct      900

ctggaactga cagaggatga tattaaagaa gatggcattg ttccacttcg ttatgttaag      960

tttcagaatg ttaacagtgt aactatattt gttcagtcga atcaaggtga agaggaaaca     1020

acaagaattt catattttac ttttattggt actccagtcc aggcaacaaa tatgaatgac     1080

ttcaaacgag tagttggcaa aaaaggagaa agccactaag gtacaaaaga cactggacaa     1140

ccatattgca atcagatcta cagctcctgg ataattgctt gattctcgcc agagactgtc     1200

aatgtttcat tcattgccat taccaataaa tcattgcttt tgttcagatg gtatcactag     1260

tgtttccatt gtaatcttga cacatgcaat tgtaaataaa agtcaccact tttgccaagc     1320

ttaatttttg tctttctaaa tcagtatttt ctctttccat gtatttgaaa actggttaac     1380

ttctgatttt agtagagact taagtgtctg gtagtatatt gattgaaagc cagtttcttt     1440

agaaaaggag aaactgttct agggaattaa gaagtacatg tgtacacatt catggcaagt     1500

tattttgata agtgaacctg gaacagctaa ccatgttaaa ttattactgc atttttatta     1560

aaggacattt gtatatctga gctatggaaa ttactcaaat tataaattag aagaaataaa     1620

caggtttaat gagatttagc tactcttacc taaaacttag ctaatgggtc cacagattct     1680

ttcttggtat atatcaagat tttaatctct tctggtaaac tttaaaattt gagtcagcct     1740

tttttttttt tttttttttt ttaactaata gaagaatgtg gaaatcagac agttggggaa     1800

aaaatacagc atagtgaatt cagaaaacag gaattggcca ggtgtggtgg ctaatgtctg     1860

taatcccagt actttgggag gccaaggcgg gcgaatcacc agaggtcagg agttcgagtc     1920

cagcttggcc aacatggtga aacctcgtct ctactaaaaa tacaaaaatt agccaggcat     1980

ggtggcgggt gtctgtaatc ccagctactt gggaggctga gacagaagaa tcggctgaac     2040

ccgggaggca gaggttgcag tgagctgaga ttgcgccatt gcgccccagc ctgagcgaca     2100

agagcaaaac tccgtctcca aaaaaaaaag ggaattatta cccttaatca agtatttatt     2160

acctgaacta ccaaaacgtg cagtgtaaat atacagagaa catgatttaa ggttgaaaat     2220

gaggtgctca aatagaaatg tttaaaaggt ctttcacaaa aggctggtaa aatacctatt     2280

cgttaccttt tttatcttaa aattgtaatc taaaaagtat tggtagtttt aattttaaaa     2340

tttctgagta ttttgaaaac tatttttaaa gagtacataa gactgtaaaa ttgtgattca     2400

gttaaacatt tgagggcatt cttgtctagg aatatggtag agataccatt tgcctttgtg     2460

agagcagtgt gtttatactt gtttatgaaa aaattctaca gaagttttag tgttgaaaga     2520

gtccctttct gaaacccaag tgtcattaga tagtttagtt catttgtata tgggcacatt     2580

aactggtctg tgatgatctt aacactcctt aaatagacca tctcagatta atcacatctg     2640

aaattaagga taagattaat atgcagggtt ttggtttaca gttttgtaca cttaaccttt     2700

ctgagtaatt gttaaagtgc ctcatcctaa gtattgctga ccttttccta tttatacttg     2760

atagtttgaa aacccagtga aacaaatttc gtatttgtaa aggattggac atcagattta     2820

tattgtctat gtgactcttc tataacaatt agttgcagta tgcaagtatt acataattca     2880

aattgtaaat agtgaaaaat gaacgtttat aggtaactat aacgtttcac ttaatgggaa     2940

atcttactat tataaatgtg cataattggc atttaaaata tcaaactgaa atgctgtttt     3000

ctcctaaaac agtatatata tatacacaca tatgtatatg taacatttat atataacact     3060

gaattttcca gatgaataag agcatttgaa aaaatgtaac tctagttatt ttaactgaag     3120

ttatttatta gtgcatctag aaaactggta ttcagtttct tgttcatttt gtcggacata     3180

gcaaaaaaga atttcatgat ctctgtattt tgatacattg acatcaggtg cttttgatga     3240

gaaacaacag tgaaatatcg tgttcataat agaaacgaaa gtcaggtatt gcagtaggaa     3300

gtctttgtca gcttaatgct gaagccaaga gtagcacaag gtaccacatt cttgtgccca     3360

cgacaggctt ttataatcct tctgagttct ctttgacatc aagccccacg ttgttcccca     3420

gtctcaatat tctgttggag gcagccacgt aacaattaga gttgaaacct gccccacgtt     3480

gttccccagt ctcaatatac tgttggaggc agccacgtaa caattagagt tgaaacctgc     3540

cccacgttgt tccccagtct caatatactg ttggaggcag ccacataaca attagagttg     3600

aaacctgccc cacgttgttc cccagtctca atattctgtt ggaggcagcc acgtaacaat     3660

tagagttgaa acctgcccca cattgttccc cagtctcaat attctgttgg aggcagccac     3720

gtaacaatta gagttgaaac ctgccccact ttgttcccca gtctcaatat tctgttggag     3780

gcagccacgt aacaattaga gttgaaacct gccccacatt gttccccagt ctcaatattc     3840

tgttggaggc agccacttaa caattagagt tgaaacctgt ctgccatcct ttgtctcaat     3900

gtttgaggat gtatgcagtg tttttggcag cgattatagg aatgcagttg tttatttggc     3960

ctcagcagtt tatttatggc tgcaattaat atccctgatc atgggctttt aaacctaaaa     4020

tagttcagat cctcccttgt tcctcttaat gtctaaaagc tttgattctg taataagaat     4080

aaagtgttgg agttgaataa attagttaca ccctttgtaa gctttaaaaa catgaaattt     4140

aaggcttact catgttgctt gtattgatac tcatatagtt caatttagta ggttaatttt     4200

tgtgttaggt atatctcttc tggaactgat aatttgtaat cttagactat ttttttttta     4260

agataagtaa cttagagtaa gaaatccagc tgggaacagt ggctcatgcc tgtaatccca     4320

gcattttggg aggccgaggc ggctggatca cttgaggtca ggagtttgag accagcctgg     4380

ctaacatgga gaaaccctgt ctctactaaa aatacaaaaa attagccagg catggtggca     4440

ggtgccacac ccagctactt gggaggctga ggcagtagaa tcgcttgaac ccgggaggcg     4500

gaggttgcag tgagccaaga tcgcatgact gcacactagc ccgggcaaca gagtgagact     4560

gtctcaaaag aaaaaaaaaa aaaatccatt cacagaactg ctaaagaaaa actagaggaa     4620

tattttgctc atttagcttt aaaactcatt attagaggtg tgtattttac agttttgtaa     4680

atatagatta tgctttataa tacacataaa gcaagtatat ataacatgca tatagtaaat     4740

aaattttaaa atattgacta ttccccagtt aagcctatac ttcttaagga agactactga     4800

tgtcatttta agcatgtttc aaaattcaag ttttattttt gatcaataag gttttttttt     4860

ttttttaaca tgctcagcac tataggaata agaggacagt ggagatttgt aggctaataa     4920

gatcgctttt aaactttgtg gtccatgtaa aattattagt tggagaatgt gtaattagag     4980

aactataaga taaagagata acctttagaa tttgaatgta ctaaaattgt acacagcttg     5040

gaatattaaa atcttaagga tatgcaatgt taaaactgct agagtatttt tccttcgtgc     5100

ttgctatgct tctctatggg aagaggaatt ttattttgga attatttcta agttgaacag     5160

accagaatta attgtgaaaa catgatctgt tggtttataa ttggacacgc atttggagat     5220

actggctcat catactacct aggagcaaaa tctctgaagt ttgaatccct gctcttccac     5280

ttgttagctg tgtcatcttg agcaagtaac atccttcaga gctcaaattt cttcttgtgt     5340

aaaaatagga acatctatct cttagacttg ttctgaagat gcgccttact ttgtatctgg     5400

aacaaggata agtatcttct gtatcctgct ctcagctgtc actgcttttt aggccatcat     5460

tacttgcttg gcatactgca gtgcctccta attgtctctt tgtttctgct ctggcctctc     5520

tcatgtatcc cccacatggc cgctggttct cttttcttta tggggtcttt gtaatgtaat     5580

ctctcctcct ctagcctccc catgcccctc atttctccag tgtgctgtgc tgtattacca     5640

ggtagcagaa cgtaccctaa tatcgcatgc cttcctctga cctaactttt ccatctgacc     5700

aattcctact tatctacaag gctcagtcca aggaaaactg ataccgggaa taatcataac     5760

aattgtgcac gcctcctcag ctgctatgac accttgccat tatttcatcc ggatacttat     5820

caagctactt gtaatgatct gtagtcttat ttggactact agattgtgag ctgtaataca     5880

agtattttgt ctctagtatt aagccagttt atttggtttc tatcattaaa tacaatgttg     5940

aaaaaattct cagggtccaa ggggagatgc ttgggttgag tcagagataa agtaggaata     6000

tgcagttgag gaaggtaagg aagataattt agctgaagta aaggaaaagt gcatagtgtg     6060

ttcatagagt gggagttaag tgtaagagac attctaggga agtgaaggag aagctgaaag     6120

agcaagtaga gacggtaagg tgaagctcct cttgccatgt gaaagagatc aaactttctc     6180

cttaatttat gggaggagcg agcatagaga agtctgtgat gtctcacaag gttctcactt     6240

ttacaattga atatagaagt agctcttagg agaagcagaa cgttcagagg ggaagatgaa     6300

tatggttttg ggtacattgc cttaaattgc atttttggta tttgggtggc gatgtctagt     6360

aagtaaaaag ccaggaatgt gattttagag cttagagcta gaagcaagga actaggagtt     6420

gtttagatga tgaaaactga aatatgtata tgaatgggaa tttttagaat ataaagggag     6480

agaatgaaac taaggagcaa atgttaggga atcctaagaa atattaaaga attgggaaaa     6540

gaggaacctg gaaggtagag tagtaaacag gaaagggagg aaaaacagga ggtggtaata     6600

aagtagtgtt aatgaatcca agagggagca gtcaccatct tcaaatgtga tattgaaatt     6660

agctgggatg tccagttgtt taatccatta aattgtggaa acagtctttc tagtgcttaa     6720

ttataggaat cattgatcat attaataaac tttcagttga agcatcagca gataattatt     6780

ccaaaaccct ctggcaaaga aatgtagatg cttttatagt ctaccattga acacagtttt     6840

acatgacact tggcaaaact tggagatgga tggcactatt ttgtaagaga atatgaaaca     6900

ctgctttgaa gttgtcatta aaggatctta tcaggtgc                             6938


<210> 198
<211> 1229
<212> DNA
<213> Homo sapiens

<400> 198
ggacgcaacc atctgcggaa aggatagggg ggaggaagac ttaacactgc aacaacaggt       60

acaaaaaaga aggaaactca gtaacaggac ccagaggacc attatatatt gctctatatt      120

ctaggtcgcc cactttacac ttccttctca tgcacttggt caataccacg cccgctgacc      180

acactggcga cttccctctc tgtcgcccct ccgtgaagtc agacccactc tgcgggccaa      240

gaaaggtgac cgggcttcct tccggcttgc taagcagagg ccggaagcgg tggtttttag      300

cggctctctg ggtagcaggg tggtgtgata gcggcagcga ggggctcgga gaggtgctcg      360

gattctcgta gctgtgccgg gacttaacca ccaccatgtc gagcaaaaga acaaagacca      420

agaccaagaa gcgccctcag cgtgcaacat ccaatgtgtt tgctatgttt gaccagtcac      480

agattcagga gttcaaagag gccttcaaca tgattgatca gaacagagat ggtttcatcg      540

acaaggaaga tttgcatgat atgcttgctt cattggggaa gaatccaact gatgagtatc      600

tagatgccat gatgaatgag gctccaggcc ccatcaattt caccatgttc ctcaccatgt      660

ttggtgagaa gttaaatggc acagatcctg aagatgtcat cagaaatgcc tttgcttgct      720

ttgatgaaga agcaactggc accatacagg aagattactt gagagagctg ctgacaacca      780

tgggggatcg gtttacagat gaggaagtgg atgagctgta cagagaagca cctattgata      840

aaaaggggaa tttcaattac atcgagttca cacgcatcct gaaacatgga gccaaagaca      900

aagatgactg aaataacttc aaattccagc caaacgttcc ttgttgccac tttgggtatt      960

ctgagatttt ctcttgcatg cccttagctt tacagctttt gcatttcctg ttgtatttat     1020

tctcagccat tttgggcata tgtatcttta taatcagact ggaaacggga ctttctatta     1080

atatcatttt cagaataaaa aataggataa tttaacctac cagcccttct cccccaataa     1140

ctgtggtcta tacagagtca atatattttt tcagagaaag ttattcgctc gattttttct     1200

gaatcataat taaactttat gataaaata                                       1229


<210> 199
<211> 1546
<212> DNA
<213> Homo sapiens

<400> 199
attggtgaag ctctaacggc tgttttgact ggcgtagccg gagccggcga cgtgaggcgg       60

gcgttgctcg cgcgacaagt agttgctggg acagcgaaat ggaggggtgt gtgtctaacc      120

taatggtctg caacctggcc tacagcggga agctggaaga gttgaaggag agtattctgg      180

ccgataaatc cctggctact agaactgacc aggacagcag aactgcattg cactgggcat      240

gctcagctgg acatacagaa attgttgaat ttttgttgca acttggagtg ccagtgaatg      300

ataaagacga tgcaggttgg tctcctcttc atattgcggc ttctgctggc cgggatgaga      360

ttgtaaaagc ccttctggga aaaggtgctc aagtgaatgc tgtcaatcaa aatggctgta      420

ctcccttaca ttatgcagct tcgaaaaaca ggcatgagat cgctgtcatg ttactggaag      480

gcggggctaa tccagatgct aaggaccatt atgaggctac agcaatgcac cgggcagcag      540

ccaagggtaa cttgaagatg attcatatcc ttctgtacta caaagcatcc acaaacatcc      600

aagacactga gggtaacact cctctacact tagcctgtga tgaggagaga gtggaagaag      660

caaaactgct ggtgtcccaa ggagcaagta tttacattga gaataaagaa gaaaagacac      720

ccctgcaagt ggccaaaggt ggcctgggtt taatactcaa gagaatggtg gaaggttaaa      780

cagcttggat ttattcttac tttgtatgtt gtgttgttgt ccccagtgtc ctacaaacta      840

atgtatttgt gcacaagaca tcatctatga atgatgaagt tttctcacct tcaaagtctt      900

ataaacatgt tgactcttgt tcctgctgag ttacttgttc gaagcttaca gcttgttttc      960

caggcatcga ataactgttg agattgttct actgttgtcg tatattcttc tatattgaat     1020

tctggttaat ttggagtaac taattctgtg gctgttgtga gtcttcagca ccctcccatg     1080

taccttatat ccctctctga aacagaacag ctccaatagc aacaagctag ttgttctgcc     1140

agatgtttct atgtggattc tgtaatgttc ctccatacag ttaaaacatc ctaacttgtt     1200

tttcaagctc actcaggcct acgccaaacg tttctgtttt ttttaaccat gaggtttaat     1260

ttatttttgt gataggaggg atatttacat attttagtgg accacatttt aagttggatg     1320

gtgtgctcta aaatactgaa aaacaatagc ccatatacct atgtatttgt ttttgatggg     1380

ttgtttactc tgaaataaaa tgtatggttt tcttaaaagg aagttttaaa gtacctattt     1440

tgtgtcatcc tgtattgaaa agaatgtcaa gcttgttaaa atgacatgta acaaaaatgt     1500

attttgattt gtatttcaga aactaaaaaa taaaatgttg aaagaa                    1546


<210> 200
<211> 2867
<212> DNA
<213> Homo sapiens

<400> 200
aattccggag gcggcattcg gtggtcagag gcctgtgcgg ctgcaggtag agtgtcttag       60

gaacctagga aataactcgg aacctgtaac gtcccactgg tttggacata ttcctctcct      120

gatctggcct catctgttcc agggaggtgg gattgaaaca tatgcagtaa tgtcacctca      180

aaagagagtt aagaacgtcc aggcacaaaa caggacttca caaggtagta gtagttttca      240

gaccacgctt tcagcctgga aagtaaaaca ggatccaagc aactcgaaga acatctcaaa      300

acatggacaa aacaatccag tgggagatta tgaacatgct gatgatcaag ctgaagaaga      360

tgctttgcaa atggcagtgg gatattttga gaaaggtccc attaaagctt cacagaataa      420

agataaaacc ttggaaaaac acttgaaaac tgtggaaaat gtggcttgga agaatgggtt      480

agcttcagaa gaaattgata ttctattaaa tattgcactc agtggcaaat ttggaaatgc      540

tgtaaacaca cggatattga agtgcatgat cccagcaaca gtaatatcag aagattctgt      600

ggttaaggca gtctcctggc tttgtgttgg caagtgttct ggtagcacca aggtactttt      660

ttatcgttgg ctggttgcaa tgtttgactt cattgatcgt aaggagcaaa ttaacttgct      720

ctatggcttc ttttttgctt cattgcaaga tgatgcactg tgcccttatg tttgccattt      780

gttatattta cttaccaaaa aagagaatgt caaaccattt cgtgtgagaa aactgcttga      840

tcttcaggcc aaaatgggaa tgcagcctca tctccaggct ttgttgtcac tgtataagtt      900

ctttgctcct gctctgattt cagtatcttt gcctgtaagg aagaagatat attttaagaa      960

ttcagagaat ctatggaaga cggctctgct tgccgtgaag caaagaaacc ggggaccttc     1020

tccagaacct ctgaagttga tgttaggtcc agctaatgtt cgtcctctaa aaagaaagtg     1080

gaattctctc tcagttatac cagtgctcaa ttccagtagc tacactaaag aatgtggaaa     1140

aaaagagatg agtctttctg attgtctgaa tagaagtgga tcatttccac tagaacaact     1200

tcaaagcttc ccccaacttt tacagaacat ccattgctta gagctgcctt ctcagatggg     1260

ctcagtgcta aacaactctc tgctgcttca ctacattaac tgtgtcagag atgagccagt     1320

cttgctgagg ttttattact ggttgagtca aacattacaa gaagaatgta tttggtacaa     1380

ggtgaataat tatgaacatg gaaaagaatt taccaacttc ctggatacca tcatcagggc     1440

agagtgcttc ttacaagagg ggttttattc ctgtgaagca ttcctgtata agagccttcc     1500

tctctgggat ggcctttgtt gtcggtcaca gttccttcag cttgtgagct ggattccttt     1560

tagtagcttc tctgaggtga aaccacttct ttttgaccat ctagcgcagc tcttctttac     1620

atcaaccatt tatttcaagt gtagtgtgct tcagagtctg aaagagctat tgcagaattg     1680

gctgttgtgg ctttctatgg acattcacat gaaacctgtt acaaacagtc ctctagagac     1740

aactttgggt ggatccatga actctgtgtc taaactgatc cactatgtag ggtggctatc     1800

cactactgca atgcgcttgg agagcaacaa tactttcttg ctgcacttta ttttggattt     1860

ctatgagaag gtgtgtgaca tatatataaa ttataacctt ccattagtgg tattgtttcc     1920

tcctgggatc ttctattctg cactcctcag cctggatacc agcatcctga accagctgtg     1980

ttttattatg cacagatatc gtaaaaattt gactgccgca aagaaaaatg agttggtaca     2040

aaagacaaaa tcagagttca atttcagcag caagacttat caagaattta atcactattt     2100

gacatcaatg gttggttgcc tgtggacgtc caaacccttt gggaaaggaa tatatattga     2160

ccctgaaatc ctagaaaaaa ctggagtggc tgaatataaa aacagtttaa atgtagtcca     2220

tcatccttct ttcttgagtt acgctgtttc ctttttgcta cagggaaaga aatggagctg     2280

gtatttggac tatttatttt cacaggggtt acaaggcttg aaacttttta taagaagtag     2340

tgttcatcat tcttccattc ccagagcaga gggcataaac tgcaacaatc aatattaaat     2400

gaatgttgac ataaactgaa cacactggac taaactcact cctcattgct agagcaaagt     2460

ggctcatctt gagttcccat tttcatttca ctgacagact gccatcctca aggagtactc     2520

agactggcct tctgttcatg gcttaggaga gccttggtgt gcctaactga tttttcaaaa     2580

tttagatttt tttagcctac cagtgaaaaa tgaccccttc atcatcaggc tctgcgttct     2640

accaaattgt atgtaaaaag acacatctgt tttgtggtag gattttttca catttttggg     2700

tactatgagc tgcattgatg gaagacagca ggcaatatgt ggtgacagtt aactcacaga     2760

cataaacatg caaaatactt tgctgtctct ggggatattg ccatttttct tactgtgagc     2820

aacagcacca acaccaagtt aacaggatgc aacatgtgta tgactct                   2867


<210> 201
<211> 2321
<212> DNA
<213> Homo sapiens

<400> 201
gggcttgccc cggcagcctc cctccctggc ttagcctcac ctcccgcgct gcgggccgtg       60

tctgggcctc cgcgcatagc acgccgggaa ttgtagtttt ctctcggcgc gctcatgccg      120

gaaagggggg gcggtgggac tgcgtctccc agagtgcagc ggggcgggcg aaggaaggca      180

ggggggaagg gacagtcggc cgcagaccgc gctgggttgc cgctgccgct gccgccatcg      240

tgccagcccc tcgggtctcc gtgaggccgg gtgacgctcc agaatgggag acaagccaat      300

ttgggagcag attggatcca gcttcattca acattactac cagttatttg ataatgatag      360

aacccaacta ggcgcaattt acattgacgc gtcatgcctt acgtgggaag gacaacagtt      420

ccaggggaaa gctgccattg tggagaagtt gtctagcctt ccgttccaga aaattcagca      480

cagcatcacc gcgcaggacc atcagcccac tccagatagc tgcatcatca gcatggttgt      540

gggccagctt aaggcggatg aagaccccat catggggttc caccagatgt tcctattaaa      600

gaacatcaac gatgcttggg tttgcaccaa tgacatgttc aggctcgccc tgcacaactt      660

tggctgacct cctctcagct aggcactcac gctgtttcct cctccctcct cttcccaata      720

ctattcccac tcctccagat gctccaaata tcatgcacaa atgagcaggg ccgcggtggg      780

agtgggcgca gtgcgctgct gccactgagg tgttgtgcat gatgtttgga tgctagacta      840

gttgcatctg acgggagaag tttgtgttgt accagcgcat gccttggaaa gacttaagta      900

atgcaaaagg ttgtcctttt tttttttttt ttttttttaa tctactgaca agttgctcta      960

gtaacccaaa gaagtgaagg agaaagcagc tgcctcaccg cccagacatt gatttgttca     1020

gatgtttcaa tgcctcatga tacaataaaa ccacaaaaat tttcttaaca gtttaaattg     1080

ttttaattag tttactagtt ggctgggcat cagaagctac ccagacccgt tgtctctctc     1140

atgtttcacc ctcccacttc tgccccaact ctgaatacct gttgcaggga gaaactgctg     1200

aagcagcact cccagctagc ctctcagaag ccgtgtaggg cagttctctc ccactccaca     1260

gggcgactgg tctttggaaa gcaggcagga agagctcagg tctggcctga agcttctctc     1320

actgaagcct gtgcagtcag ttctgatacc tcctgtgact tctgctctgg gtaggttcag     1380

ggccctagta gcaggagaga tgatcctgaa tcctgttgaa gctggagagg ccttggcaaa     1440

atggctcatc acgttcaggc cctccgggct gagttgtcag cagtatcaag ggaggggcct     1500

gctctatccc cagaaggatc aggatcatat ccaggatgcc ccacatacac caagccaggc     1560

agagggcagc tcagctcctg tcccatctgc tttggatatc tttacccaaa ggcaggtaac     1620

ccgaagagcc agcctccact gcccacagag ccaggcccag ttgtgttgga gtataggtca     1680

ggagctgtgg aaggaggcag tctgtgaggg actcatgctt taggagtcct cacccctcag     1740

actgctgcag gacattgcca ggcctctctc cacttccttc ctcagcatac agacttcatg     1800

ctatcttcca attccgggga gtcttagcta ttagggcagt ttctgcttct ccattttggg     1860

gacaaaggcc ttgcccagta caaatctagc cccttgtccc acagacttct ggatggtata     1920

aacctagtgg caatgtagca accataggct agaaccaaac ccaagatttg ggtcagtgcc     1980

ctgttaaggg ttttaggatt ggtaaggaca ccacagctaa atctgacatg taaaaggata     2040

cccttcccct gtcccactac gggtggaggc taaggacctc ctcagatccc acagattgcc     2100

tggtgacatt gggcacaggg ctggatggtg tgctgtttga gaggacagca tgctcaggag     2160

atttcagtgg gaatgatctc taggctgatg tgtatttggg gaagtggggg tggggaagag     2220

gtaggtgcct gctgcctcaa accaccttgt gtaaaatctg caatacggct tcttccatgt     2280

acctgtgcct gaactgtctg caataaagaa gaatttgtaa a                         2321


<210> 202
<211> 2130
<212> DNA
<213> Homo sapiens

<400> 202
aggaggcggg gcgccgcgcc cctccggcag tcaccgaggc ccggacctgc ggcgtcggcg       60

gcgcgcgcag agggccaggc gggcgtagag gccggaccga cgcgtggcgg cagagggtat      120

ccaaggccgg acctggcgcg caggcgctga cccgacctgg cagtgagctg gccgcggcct      180

tggctgagag gccttaaccc cgccgggcgg ccgcgccctg catgcgagtt gggccgcggg      240

cggggttgga gcctactcgg ggcgactgcg atggacgcct tagaaggaga gagctttgcg      300

ctgtctttct cctccgcctc tgatgcagaa tttgatgctg tggttggata tttagaggac      360

attatcatgg atgacgagtt ccagttatta cagagaaatt tcatggacaa gtactacctg      420

gagtttgaag acacagaaga gaataaactc atctacacac ctatttttaa tgaatacatt      480

tctttggtag aaaaatacat tgaagaacag ctgctgcagc ggattcctga gttcaacatg      540

gcagccttca ccacaacatt acagcaccat aaggatgaag tggctggtga catattcgac      600

atgctgctca ccttcacaga ttttctggct tttaaagaaa tgtttttgga ctacagagca      660

gaaaaagaag gccgaggact ggacttaagc agtggcttag tggtgacttc attgtgcaaa      720

tcatcttctc tgccagcttc ccagaacaat ctgcggcact aggtcctacc tccagccaat      780

gaatgggatc attctggatg tcaccagccc aataggctca gctcatgatg acagaacaca      840

tcttggaaag actgactctg ttatgtaact cttcatttat gttaagtatt aataggtcaa      900

aaccaaaatg acctaaccct cctggaccta tttatcctga aacaccttct tgtattcatt      960

aaccatagta ctcctcccca cctcaagtag acacctctct caggagcttc tgagtcagac     1020

gcctctggag cgagccctat gtcaggcact ccacctgggg ggcccttccc cagcatacct     1080

gctggtgtgt aagtgtggac taacccgccg ccaccaccct ctgttccagc aggctctgca     1140

tgaatctttg tgcacttgca cctctttttc acatgggcca cagtttcagt acttcagcct     1200

cagtggggtt cctgatgttt atctagggtg ttactcaagc ccagtttgag attttggagt     1260

ctcctgtgat cacatcttgt ctcggctgta ggaatcaaca gaaggagacg tcctctacat     1320

aaaagctcca tgtgaaaagc tactcctagt cttaacattt gcagtccttg tgtcactgtc     1380

ttctggtcct gatgtagtcc cactgtttct agaagtctct tttaagcatt atttttgaaa     1440

aaaaaaatat ttttatagat gaatactcag gctaacctag tggatgtgat cttggaactt     1500

ccatgattat ccacttaaag atcaaagtat tatatgctgt gtgcttttta ggtgtttgtt     1560

agtactgtga aggcaaaaat gctttctaca ttgacattca ttcctatttt actgggcacc     1620

tatgaatgta tgctgtgtgc tagaaataga ctaaaacata ttcctatagc atgttagtgt     1680

gtttgcatgt ttgctgaaaa tcctttgtgt ataaaccagt ttgtaaggtt ctctgggtta     1740

ggtagggact ctgcagtttc ttcctgtcaa aatctctcct accaagatgg tgttccactg     1800

tccagcccag catgagtagc aggtagagca cagctttact ggctgtttgt atgctttggt     1860

ttagtgcaat gtgtggtaga ttacttatca gaaaacatat atgtcatctc tagaacgaag     1920

aaaaagcata gtagttcaat tcccagtgtg tccctttgat tttttttttt taatagtaaa     1980

aataagaatc tgtactgact tttcacttgg ccattctggt tttaaaggac aagctacaag     2040

ctctgtgttt ctgtactgat gtgtcactta ttaaatactt ttgtaccatg agtaaaactt     2100

caggtgtttc gcaagaacca ccattctcaa                                      2130


<210> 203
<211> 942
<212> DNA
<213> Homo sapiens

<400> 203
gagcgccgag cggggcggcg gcggggcggg cggcggctcc tcggcggctc cgcggcgccc       60

gggccgcgcg ccgccatgct gggcctggac gcgtgcgagc tgggggcgca gctgctggag      120

ctgctccggc tggcgctgtg cgcccgagtc ctcctggctg acaaggaggg tgggccgccg      180

gcagtggacg aggtgttgga tgaggctgtg cccgagtacc gggcgccggg gaggaagagc      240

ctcttggaga tccggcagct ggacccggac gacaggagcc tggccaagta caagcgggtg      300

ctgctggggc ccctgccacc ggccgtggac ccaagcctgc ccaatgtgca ggtgaccagg      360

ctgacactcc tgtcggaaca ggctccgggg cccgtcgtca tggatctcac aggggacctg      420

gctgttctga aggaccaggt gtttgtcctg aaggaaggtg ttgattacag agtgaagatc      480

tccttcaagg tccacaggga gattgtcagc ggcctcaagt gtctgcacca cacctaccgc      540

cggggcctgc gcgtggacaa gaccgtctac atggtgggca gctatggccc gagcgcccag      600

gagtatgagt ttgtgactcc ggtggaggaa gcgccgaggg gtgcgctggt gcggggcccc      660

tatctggtgg tgtccctctt caccgacgat gacaggacgc accacctgtc ctgggagtgg      720

ggtctctgca tctgccagga ctggaaggac tgaaccccca gtccgtgtct cccctacctc      780

cctcagttgt tgcacaggga cccccaagca tccccagcac cccccgtgag tgaccagacc      840

ctcccctgct gcccctgctg cccctgctgc ccctgctctg tcccgggacc ccctggcctg      900

gcgctgtccc ctgagctgtc ccattaaaca tggccctgtc tc                         942


<210> 204
<211> 988
<212> DNA
<213> Homo sapiens

<400> 204
cagccgcacg tgggctcggc gcgatggagg aggagacgca tactgacgcc aaaatccgtg       60

ctgaaaatgg aacagggtcc agccctcggg gtcctggctg cagcctccgg cactttgcct      120

gcgaacagaa cctgctgtcg cggccagatg gctctgcttc cttcctgcaa ggtgacacct      180

ctgtcctggc gggtgtgtac gggccggccg aggtgaaggt cagcaaagag attttcaaca      240

aggccacact cgaagtgatc ctgaggccga agattgggct gcctggtgtt gcagagaaga      300

gccgggagcg gctgatcagg aacacgtgcg aggcggtggt gctgggcacg ttgcaccccc      360

gcacctccat caccgtggtg ctgcaggttg tcagcgatgc cggctctctc ctggcctgtt      420

gtctgaatgc cgcctgcatg gcattggtgg atgcaggtgt gcccatgcgg gctctcttct      480

gtggggtcgc ctgcgccctg gactctgatg ggaccctcgt gctggatcct acatccaagc      540

aagaaaagga ggcccgggca gtcctgacct ttgccctgga cagcgtggaa cggaagctgc      600

tgatgtccag caccaagggg ctctactcag acactgagct ccagcagtgc ctggctgcgg      660

cccaggccgc ttcgcaacac gtcttccgtt tctaccggga atcgctgcag aggcgttact      720

ccaagagctg aggcaagctg gggcaagggg ccgctcccat tgcctccacc cactcacccc      780

ctacagcctg aagcaaacca gcagcccagc cttgcctctc tgacccatgg gctccttgag      840

cctgcagctc tgtaaccaca gggctcctgt ggggaggcct tggcctgtga cagcccccag      900

gcctgggggc acagatcccc ccagcaagga taacattcaa aggagctcac atttatggaa      960

tggatgaatc aataaattaa ttcacttt                                         988


<210> 205
<211> 1765
<212> DNA
<213> Homo sapiens

<400> 205
atgccctgga agttgtggag agggagtgtt gggtgtcctg gggacctgtc ctctgatggg       60

ctcttgttcc ggctaggacc ccccaaaccc cccaccgagc tggagcctga gccggagata      120

gaggggctgc tgacaccagt gctggaggct ggcgatgtgg atgaaggccc tgtagcaagg      180

cctctcagcc ccacgaggct gcagccagca ctgccaccgg aggcacagtc ggtgcccgag      240

ctggaggagg tggcacgggt gttggcggaa attccccggc ccctcaaacg caggggctcc      300

atggagcagg cccctgctgt ggccctgccc cctacccaca agaaacagta ccagcagatc      360

atcagccgcc tcttccatcg tcatgggggg ccagggcccg gggggccgga gccagagctg      420

tcccccatca ctgagggatc tgaggccagg gcagggcccc ctgctcctgc cccaccagct      480

cccattccac ccccggcccc gtcccagagc agcccaccag agcagccgca gagcatggag      540

atgcgctctg tgctgcggaa ggcgggctcc ccgcgcaagg cccgccgcgc gcgcctcaac      600

cctctggtgc tcctcctgga cgcggcgctg accggggagc tggaggtggt gcagcaggcg      660

gtgaaggaga tgaacgaccc gagccagccc aacgaggagg gcatcactgc cttgcacaac      720

gccatctgcg gcgccaacta ctctatcgtg gatttcctca tcaccgcggg tgccaatgtc      780

aactcccccg acagccacgg ctggacaccc ttgcactgcg cggcgtcgtg caacgacaca      840

gtcatctgca tggcgctggt gcagcacggc gctgcaatct tcgccaccac gctcagcgac      900

ggcgccaccg ccttcgagaa gtgcgaccct taccgcgagg gttatgctga ctgcgccacc      960

tacctggcag acgtcgagca gagtatgggg ctgatgaaca gcggggcagt gtacgctctc     1020

tgggactaca gcgccgagtt cggggacgag ctgtccttcc gcgagggcga gtcggtcacc     1080

gtgctgcgga gggacgggcc ggaggagacc gactggtggt gggccgcgct gcacggccag     1140

gagggctacg tgccgcggaa ctacttcggg ctgttcccca gggtgaagcc tcaaaggagt     1200

aaagtctagc aggatagaag gaggtttctg aggctgacag aaacaagcat tcctgccttc     1260

cctccagacc tctccctctg ttttttgctg cctttatctg cacccctcac cctgctggtg     1320

gtggtccttg ccaccggttc tctgttctcc tggaagtcca gggaagaagg agggccccag     1380

ccttaaattt agtaatctgc cttagccttg ggaggtctgg gaagggctgg aaatcactgg     1440

ggacaggaaa ccacttcctt ttgccaaatc agatcccgtc caaagtgcct cccatgccta     1500

ccaccatcat cacatccccc agcaagccag ccacctgccc agccgggcct gggatgggcc     1560

accacaccac tggatattcc tgggagtcac tgctgacacc atctctccca gcagtcttgg     1620

ggtctgggtg ggaaacattg gtctctacca ggatccctgc cccacctctc cccaattaag     1680

tgccttcaca cagcactggt ttaatgttta taaacaaaat agagaaactt tccttataaa     1740

taaaagtagt ttgcacagaa attga                                           1765


<210> 206
<211> 2659
<212> DNA
<213> Homo sapiens

<400> 206
gggtggaagt gacgctgccc ccgctgccca aaatgtcggc gcccagaggg aggtagagag       60

cccccacata ccactgtatt ccccgccacc atggatgacg tccccgcccc aacccctgca      120

ccagcaccgc ccgccgctgc cgcccccagg gtcccgtttc actgcagtga atgtggcaag      180

agcttccgct accgctcaga cctgcggcgc cactttgccc ggcacacagc gctcaagccc      240

cacgcatgtc cgcgctgcgg caagggtttc aagcacagct tcaacctagc caaccacctg      300

cgctcgcaca ccggggagcg gccctaccgc tgctctgcct gccccaaggg gttccgcgac      360

tccaccggcc tgctgcacca ccaggtcgtc cacactggtg agaaacccta ctgctgcctg      420

gtctgcgagc tccgcttctc ctcacgctcc agcctgggcc gccacctcaa gcgccagcac      480

cgtggggttc tcccctctcc cctgcagccc ggccctggcc tgcccgcctt gagtgcgccc      540

tgctccgtct gctgcaatgt ggggccctgc tcggtgtgcg ggggctcagg ggccggcggc      600

ggagagggcc ccgagggggc aggcgcgggt ctgggcagct gggggctggc agaggcggca      660

gctgcggccg cggcctcctt gcccccattt gcgtgcggcg cctgcgcgcg gcgcttcgac      720

cacggccgcg agctggcggc ccactgggcg gcgcacaccg acgtgaagcc cttcaagtgc      780

ccgcgctgcg agcgcgactt caacgcgccc gcgctgctgg agcggcacaa gctgacgcac      840

gacctgcagg gcccgggcgc gcccccagcg caggcctggg ccgcggggcc aggcgcaggg      900

cccgagacgg cgggcgaagg caccgctgcg gaggcgggcg acgctcctct ggcttcggac      960

cgcaggctgc tcctgggccc cgcggggggc ggcgtgccca agctcggggg gctgctcccc     1020

gagggcggtg gggaggcgcc tgcacctgcg gcggccgccg agccctcgga agacaccctg     1080

taccagtgcg actgcgggac cttctttgcg tcggccgcgg ccctggccag tcacctggag     1140

gcccactcgg gcccggccac ctacggctgc ggccactgcg gggctctgta cgcggcgctg     1200

gccgccttgg aggagcaccg gcgggtcagc cacggtgagg gcggcgggga ggaggcggcg     1260

accgccgccc gggaaaggga accggcgtcc ggggaacccc cgtctggctc cggccgcggc     1320

aagaagatct tcggctgctc cgagtgcgag aagctgttcc gctcaccgcg agacctggag     1380

cggcacgtgc tggtgcacac tggcgagaag ccgttcccgt gcctggagtg cggcaagttc     1440

ttccgccacg agtgctacct caagcgccac cggctgctgc acggcaccga gcggcccttc     1500

ccttgccaca tctgcggcaa gggcttcatc acgctcagca acctctccag gcacctgaag     1560

ctgcaccggg gcatggactg actgccaggc tgcgtgcgcc ctgccctcca cccagcctcc     1620

tggactcggc ctggaccagg ggacctcggg actgcgcgtg aggccccggc cctccaaatc     1680

caaatccaga cgcaggccct gaaatgaggg gaccctgact ggagaggtgg gggccaccaa     1740

aaacccacaa aggccccgga gctgggggac cacaaacaaa cagggtcctt agctggggca     1800

ggggagccca aatctaggga gagactcctg agcctgaggt ccctggaatg agtgtgggta     1860

gccgtaagtc cccaagacat ggggactttg cagtgagcaa tgggtctcca caagtacctc     1920

tcatcttgag agccctaata ctaaaagatg ggcacccacc cccaccaagg gaagactgcc     1980

ccattccctg agagccatca ttcctaacga ccttgatctg gagaatgtgg agggagcatg     2040

tccctgaatt ttcctagatc cctccaaatg ccacccacca gagtcactgg tgaccccaga     2100

aaatggatat agccgaaatc tgcctttccc ctttttcatt ccctgtgctg aaagagggac     2160

cagggtagat gccccctgcc ctcgaatccc ccctccccga ctgtggaatg gatcgaccct     2220

aacgatcttc cccgccccaa acactagaat agactggcct gaaatcccct tgcccagtag     2280

aatggactga tctatgtgca cacaccccca tcacatggaa tgggctggtc taggctgtgg     2340

cctgccacct tccttagagt gaatagggcg gacactcctc tcttttcctg tagcgtgtgg     2400

accggtccac gcaattcttt atcctgtgaa ctcatctgag tgggaggtgg tggacactgg     2460

ggtttccttc cctctctccg tagcatccgt tggtctttct ctccatctct gttggtttgt     2520

ctgtctctgt cttcctccca atccctaggg gaagggggca tttggctagg gggtgcccct     2580

gtgagcctcg accttgcccc ctcgtccctc tccccagtgt ttccaggacc cccaataaac     2640

cttgtcctgt cagtcgctg                                                  2659


<210> 207
<211> 3346
<212> DNA
<213> Homo sapiens

<400> 207
gttgcccagg gcaaccgctc cttcaggcgt gaatgtggcg gctgcctctg cgaatggacg       60

gcgtgggaag agaatggctt ctgcaaggaa agccagccgt cccatgcgtg atgtttttgg      120

tgacttcagt gatgtttcct tggaagattc aacaatggaa gaaatcagaa acttccagat      180

cagtagaaat cttaccaaaa tagcacctgg tcatagcaga tttctaaaaa gaaaccaaac      240

tctagatgag aaacacttac tcctgaaaga gaaccctgtg ctcgggagtg gacccaggct      300

tgcctcatgt agaccgccca ccactgcctc caggatccga gccaatgccg cactcatgaa      360

gctggcccag ctggaaaccc ggatcatgaa tcggaagctg cagaggaatt tgtctgacac      420

ggaatctgac tcaatgaccg ccgatgctgg tcttccaaag agagctgaca gaatcctctc      480

tgggggtgca ctcgaactcg cgtcccagaa cacagacaaa acttcccaga atcaagcccg      540

tgaacttcct gtcaccgaaa ataatgcaca gaacgcgaag gtcagtaggt ttctaaagaa      600

gaaacaagca cctgttgaaa acatatcccc tgaagcacct gctgggaaag agaggacttt      660

gcaaaccccc aaacagaaag aacctgctag aacatttgat tctccagaca gtgacgaaga      720

agaaatgaaa gtattgctag gaagcttgat ggactcttct agagaaaaaa acacgaatca      780

aggcttcagc agcgctaacg tcagcgagga agaagaaaga aaactatttt cggtcccatc      840

tcaactgaga gcatttactg tacccagcgt ggaactctcc agcgcaaagc cttctcagac      900

atcacacctg ccaacctccc tggcagcaga cagaaccctt cacagcactc gctcaagagc      960

agactaccca cagagtcacg tttccagtga caccgcctcc cacacgccgt cagtttccat     1020

cacaggcgcc ttttcaaact cagtgtcttt aaagatgggg catgtcaagc ttgtgtcctc     1080

cccgggaagg agtgaggctg agactgtgga cgagccagtc tcagaaggtg ctgatgacag     1140

cctcgacgag tttagaataa atattttatc gcttgacggt ctggctccag ctgtcagtga     1200

gaactccgat ttggaacagg aagaggaaag tgctcagaga caaaaaacag ctggcaaaat     1260

cttcagagcc gaggcgtcca ctgggcagga tgccccgagg caggcccagg cgaggagctg     1320

ggcatcacag ggaaaggccg cctctgcaga gggggatgag agcgaggtct cggagcatct     1380

cagtgccagc tcggcttctg ccatccagca ggacagcact tccagcatgc agccaccatc     1440

tgaagccccc atggtgaaca cagtcagctc agcttattcg gaggattttg aaaactctcc     1500

aagtctgaca gcatctgagc caaccgccca ttccaaggag tctcttgaca gaacactgga     1560

cgctttgtct gaatcctctt caagtgtgaa gacagacctt ccacaaacag ccgagtctag     1620

gaaaaagtcg ggcaggcacg tgacaagagt gcttgtgaag gacacagctg tgcagacgcc     1680

agatcctgcc ttcacctacg agtggaccaa ggtggccagc atggcagcca tggggcctgc     1740

cctgggaggc gcctacgtgg acccgacacc catcgccaat catgttatca gtgcagatgc     1800

aatagaagcc ctgaccgctt acagcccggc cgtgctggca ctccatgatg tgctgaagca     1860

gcagctgagc ctgacgcagc agttcatcca ggccagccgg cacctgcacg cctccctcct     1920

gcgctccctg gacgcggact ccttccacta ccacaccctg gaggaagcca aagagtacat     1980

taggtgccac agacctgccc cactgaccat ggaggatgcc ctggaggagg tgaacaagga     2040

gctgtgagcg ccagcaggtg gagcttgacg tgacgtctta acaaaagcaa agcaccgcag     2100

cttcccagag ttaccagcgc agcacttaag acaggatctt acggcggggt ggggctcctg     2160

gaccgtgacc ggcgtcttct tcctggggag tacgacttgg accgggaccg cgactgggac     2220

cgggagcggc ttctggagga gcgcgacctg ctccgacttc tgcagggaag ggtgcccaag     2280

ggtcagcagc agccaggcgt cgtggggagg ccacaggaag aggcctcagg cactgccctg     2340

aggcagcctc tgcctaccta gatctggagc gggagtagga acgggagcag gagcgcgacc     2400

ttgaccttga gtacgagcct gaagacttgg aggatcttga gttggagcgg gaggaagaac     2460

gccctcgact cttggatctg ctccgagacc tcgagggtcc gctgtgggga gaggcctgat     2520

gatcaggtgc cccagtggat gggctgcacc cagcccaccc tggccctcag gttcctagac     2580

caccccagat gcaggggctc tggctgtgga tgtggcgcca tagccacagc aacggtacca     2640

agttcctaaa tagtgtggcc gagcctgctg ctgtgtgaat tcaggccttg tggaaaacac     2700

cgccccatag gcacaggctg tgtgagggtg gacgtgatga gtgtatctgg ggtctgctcc     2760

cacccatcac aagctgtgga ccctggcccc ccggccactg cagacatctg cgcttttacc     2820

tgttcctctt ctcctggcct ttcctccgcc gggcccgcat ttttgctcgg aagaactcat     2880

agaggccgtt ctgctcccag ccttcactgt aagacacggc attccgtgtg tgaccacgtg     2940

acacccaccc acaaggaagt cgtgaaaaag tcatcaggag ttaatccaca gaaccttgga     3000

gagtacatgg ccctgtggct gtgggctccg agcatgggcg cagtagagct tggttcagtg     3060

ttcccacagg gctgtcctcc tgcagcccag tggctcctct ggtgcccacg cccttgccac     3120

cctgctgttc cgctgaggtg gtggggaccc atggtctgtg gaactgggaa acaggaacac     3180

tgactcatgg gtggacaggc ctgcagccca gcacaggaag gaggggtgac cactgggaag     3240

ggtgggctga gggccctgtg gcagccggct gcttgagacg tgccgccgtg ccacaccttc     3300

cctaacttct tctgatgtgt ctccattaaa acgcccttca ttgagg                    3346


<210> 208
<211> 558
<212> DNA
<213> Homo sapiens

<400> 208
aggccgcgct cgcgccgagg ggctgcgaga gtgaccgcgg ctgctccagc gctgacgccg       60

agccatggcg gacgaggagc ttgaggcgct gaggagacag aggctggccg agctgcaggc      120

caaacacggg gatcctggtg atgcggccca acaggaagca aagcacaggg aagcagaaat      180

gagaaacagt atcttagccc aagttctgga tcagtcggcc cgggccaggt taagtaactt      240

agcacttgta aagcctgaaa aaactaaagc agtagagaat taccttatac agatggcaag      300

atatggacaa ctaagtgaga aggtatcaga acaaggttta atagaaatcc ttaaaaaagt      360

aagccaacaa acagaaaaga caacaacagt gaaattcaac agaagaaaag taatggactc      420

tgatgaagat gacgattatt gaactacaag tgctcacaga ctagaactta acggaacaag      480

tctaggacag aagttaagat ctgattattt actttgttta ttgtctatat gccttttaaa      540

aaaataaact tgttatgc                                                    558


<210> 209
<211> 1473
<212> DNA
<213> Homo sapiens

<400> 209
gccgcctcgg gctcggctct ctccgcgcag aggtttcatg gcttgcttca atcttttgat       60

atcttagagt aattgcttcc aatttttggg catcgccgcc tcagtttaca gaatagtatg      120

gatctggtgc cagagccggg aaaacgatgc gcatcgtaaa ccgcaaaaca ctgagcatcc      180

aggacagaag ccaaggcgct tggcttggtt gaaggccagt gcgcatgcgc gagtttaccc      240

ttcgcggact gggcgagctc ttgccactcc tacctccggg cttcagtctt cgccgcctgt      300

tctggtcctt tcccgggccg ctattggaag aaccgtgaac tatggaaggc ccctctggat      360

tggctgggct ggcccaagag taaggagagc cctcttcctg gcggtgggga agggacggcg      420

gcgattggcg gacgctcctg gcaggagagc gcggattggt caggcacgga gcaggaggcg      480

gggctgatag cccagcagca gcagcggcgg cggcggctgc ggagcgggtg tgaggcggct      540

ggaccgcgct gcaggcatcc gcagggcgcg gcaagatgga ggtgacgggg gtgtcggcac      600

ccacggtgac cgttttcatc agcagctccc tcaacacctt ccgctccgag aagcgataca      660

gccgcagcct caccatcgct gagttcaagt gtaaactgga gttgctggtg ggcagccctg      720

cttcctgcat ggaactggag ctgtatggag ttgacgacaa gttctacagc aagctggatc      780

aagaggatgc gctcctgggc tcctaccctg tagatgacgg ctgccgcatc cacgtcattg      840

accacagtgg cgcccgcctt ggtgagtatg aggacgtgtc ccgggtggag aagtacacga      900

tctcacaaga agcctacgac cagaggcaag acacggtccg ctctttcctg aagcgcagca      960

agctcggccg gtacaacgag gaggagcggg ctcagcagga ggccgaggcc gcccagcgcc     1020

tggccgagga gaaggcccag gccagctcca tccccgtggg cagccgctgt gaggtgcggg     1080

cggcgggaca atcccctcgc cggggcaccg tcatgtatgt aggtctcaca gatttcaagc     1140

ctggctactg gattggtgtc cgctatgatg agccactggg gaaaaatgat ggcagtgtga     1200

atgggaaacg ctacttcgaa tgccaggcca agtatggcgc ctttgtcaag ccagcagtcg     1260

tgacggtggg ggacttcccg gaggaggact acgggttgga cgagatatga cacctaagga     1320

attcccctgc ttcagctcct agctcagcca ctgactgccc ctcctgtgtg tgcccatggc     1380

ccttttctcc tgaccccatt ttaattttat tcattttttc ctttgccatt gatttttgag     1440

actcatgcat taaattcact agaaacccag aaa                                  1473


<210> 210
<211> 1671
<212> DNA
<213> Homo sapiens

<400> 210
ggcggggttt cccgcgctcg gcggaagcgg aaggggcggg gctccgcgct cctagtctcc       60

actgctgccg ccgtcgccgc cacccgagcc ggagcgggct gggccgccaa ggcaagatgg      120

tggactacag cgtgtgggac cacattgagg tgtctgatga tgaagacgag acgcacccca      180

acatcgacac ggccagtctc ttccgctggc ggcatcaggc ccgggtggaa cgcatggagc      240

agttccagaa ggagaaggag gaactggaca ggggctgccg cgagtgcaag cgcaaggtgg      300

ccgagtgcca gaggaaactg aaggagctgg aggtggccga gggcggcaag gcagagctgg      360

agcgcctgca ggccgaggca cagcagctgc gcaaggagga gcggagctgg gagcagaagc      420

tggaggagat gcgcaagaag gagaagagca tgccctggaa cgtggacacg ctcagcaaag      480

acggcttcag caagagcatg gtaaatacca agcccgagaa gacggaggag gactcagagg      540

aggtgaggga gcagaaacac aagaccttcg tggaaaaata cgagaaacag atcaagcact      600

ttggcatgct tcgccgctgg gatgacagcc aaaagtacct gtcagacaac gtccacctgg      660

tgtgcgagga gacagccaat tacctggtca tttggtgcat tgacctagag gtggaggaga      720

aatgtgcact catggagcag gtggcccacc agacaatcgt catgcaattt atcctggagc      780

tggccaagag cctaaaggtg gacccccggg cctgcttccg gcagttcttc actaagatta      840

agacagccga tcgccagtac atggagggct tcaacgacga gctggaagcc ttcaaggagc      900

gtgtgcgggg ccgtgccaag ctgcgcatcg agaaggccat gaaggagtac gaggaggagg      960

agcgcaagaa gcggctcggc cccggcggcc tggaccccgt cgaggtctac gagtccctcc     1020

ctgaggaact ccagaagtgc ttcgatgtga aggacgtgca gatgctgcag gacgccatca     1080

gcaagatgga ccccaccgac gcaaagtacc acatgcagcg ctgcattgac tctggcctct     1140

gggtccccaa ctctaaggcc agcgaggcca aggagggaga ggaggcaggt cctggggacc     1200

cattactgga agctgttccc aagacgggcg atgagaagga tgtcagtgtg tgacctgccc     1260

cagctaccac cgccacctgc ttccaggccc ctatgtgccc cttttcagaa aacagataga     1320

tgccatctcg cccgctcctg acttcctcta cttgcgctgc tcggcccagc ctggggggcc     1380

cgcccagccc tccctggcct ctccactgtc tccactctcc agcgcccatt caagtctctg     1440

ctttgagtca aggggcttca ctgcctgcag ccccccatca gcattatgcc aaaggcccgg     1500

gggtccgggg aagggcagag gtcaccaggc tggtctacca ggtagttggg gagggtcccc     1560

agccaagggg ccggctctcg tcactgggct ctgttttcac tgttcgtctg ctgtctgtgt     1620

cttctatttg gcaaacagca atgatcttcc aataaaagat ttcagatgct c              1671


<210> 211
<211> 2188
<212> DNA
<213> Homo sapiens

<400> 211
gagccggagc ccaagccaga gcggcgcggc ctggaagagg ccagggcccg ggggaggcgg       60

cggcagcggc ggcggctggg gcagcccggg cagcccgagc cccgcagcct gggcctgtgc      120

tcggcgccat gagcggcggc gggccttcgg gaggcggccc tgggggctcg ggcagggcgc      180

ggactagctc gttcgcggag cccggcggcg gaggcggagg aggcggcggc ggccccggag      240

gctcggcctc cggcccaggc ggcaccggcg gcggaaaggc atctgtcggg gccatgggtg      300

ggggcgtcgg ggcctcgagc tccgggggtg gacccggcgg cagcggcgga ggaggcagcg      360

gaggccccgg cgcaggcact agcttcccgc cgcccggggt gaagctgggc cgtgacagcg      420

ggaaggtgac cacagtcgta gccactctag gccaaggccc agagcgctcc caagaagtgg      480

cttacacgga catcaaagtg attggcaatg gctcatttgg ggtcgtgtac caggcacggc      540

tggcagagac cagggaacta gtcgccatca agaaggttct ccaggacaag aggttcaaga      600

accgagagct gcagatcatg cgtaagctgg accactgcaa tattgtgagg ctgagatact      660

ttttctactc cagtggcgag aagaaagacg agctttacct aaatctggtg ctggaatatg      720

tgcccgagac agtgtaccgg gtggcccgcc acttcaccaa ggccaagttg accatcccta      780

tcctctatgt caaggtgtac atgtaccagc tcttccgcag cttggcctac atccactccc      840

agggcgtgtg tcaccgcgac atcaagcccc agaacctgct ggtggaccct gacactgctg      900

tcctcaagct ctgcgatttt ggcagtgcaa agcagttggt ccgaggggag cccaatgtct      960

cctacatctg ttctcgctac taccgggccc cagagctcat ctttggagcc actgattaca     1020

cctcatccat cgatgtttgg tcagctggct gtgtactggc agagctcctc ttgggccagc     1080

ccatcttccc tggggacagt ggggtggacc agctggtgga gatcatcaag gtgctgggaa     1140

caccaacccg ggaacaaatc cgagagatga accccaacta cacggagttc aagttccctc     1200

agattaaagc tcacccctgg acaaaggtgt tcaaatctcg aacgccgcca gaggccatcg     1260

cgctctgctc tagcctgctg gagtacaccc catcctcaag gctctcccca ctagaggcct     1320

gtgcgcacag cttctttgat gaactgcgat gtctgggaac ccagctgcct aacaaccgcc     1380

cacttccccc tctcttcaac ttcagtgctg gtgaactctc catccaaccg tctctcaacg     1440

ccattcttat ccctcctcac ttgaggtccc cagcgggcac taccaccctc accccgtcct     1500

cacaagcttt aactgagact ccgaccagct cagactggca gtcgaccgat gccacaccta     1560

ccctcactaa ctcctcctga gggccccacc aagcaccctt ccacttccat ctgggagccc     1620

caagaggggc tgggaagggg ggccatagcc catcaagctc ctgccctggc tgggccccta     1680

gactagaggg cagaggtaaa tgagtccctg tccccacctc cagtccctcc ctcaccagcc     1740

tcacccctgt ggtgggcttt ttaagaggat tttaactggt tgtggggagg gaagagaagg     1800

acagggtgtt ggggggatga ggacctccta cccccttggc cccctcccct cccccagacc     1860

tccacctcct ccagaccccc tcccctcctg tgtcccttgt aaatagaacc agcccagccc     1920

gtctcctctt cccttccctg gcccccgggt gtaaatagat tgttataatt tttttcttaa     1980

agaaaacgtc gattcgcacc gtccaacctg gccccgcccc tcctacagct gtaactcccc     2040

tcctgtcctc tgcccccaag gtctactccc tcctcacccc accctggagg gccaggggag     2100

tggagagagc tcctgatgtc ttagtttcca cagtaaggtt tgcctgtgta cagacctccg     2160

ttcaataaat tattggcatg aaaacctg                                        2188


<210> 212
<211> 1225
<212> DNA
<213> Homo sapiens

<400> 212
gttttcccga acgcccgcag cagggtcaga agggaggtgg ccggtctccg tcgtgacctc       60

tgacggtttc tgagcgttgg cctttggcac gcgctacccc cttttgcttt ggttctgcca      120

tgccgatgta ccaggtaaag ccctatcacg ggggcggcgc gcctctccgt gtggagcttc      180

ccacctgcat gtaccggctc cccaacgtgc acggcaggag ctacggccca gcgccgggcg      240

ctggccacgt gcaggaagag tctaacctgt ctctgcaagc tcttgagtcc cgccaagatg      300

atattttaaa acgtctgtat gagttgaaag ctgcagttga tggcctctcc aagatgattc      360

aaacaccaga tgcagacttg gatgtaacca acataatcca agcggatgag cccacgactt      420

taaccaccaa tgcgctggac ttgaattcag tgcttgggaa ggattacggg gcgctgaaag      480

acatcgtgat caacgcaaac ccggcctccc ctcccctctc cctgcttgtg ctgcacaggc      540

tgctctgtga gcacttcagg gtcctgtcca cggtgcacac gcactcctcg gtcaagagcg      600

tgcctgaaaa ccttctcaag tgctttggag aacagaataa aaaacagccc cgccaagact      660

atcagctggg attcacttta atttggaaga atgtgccgaa gacgcagatg aaattcagca      720

tccagacgat gtgccccatc gaaggcgaag ggaacattgc acgtttcttg ttctctctgt      780

ttggccagaa gcataatgct gtcaacgcaa cccttataga tagctgggta gatattgcga      840

tttttcagtt aaaagaggga agcagtaaag aaaaagccgc tgttttccgc tccatgaact      900

ctgctcttgg gaagagccct tggctcgctg ggaatgaact caccgtagca gacgtggtgc      960

tgtggtctgt actccagcag atcggaggct gcagtgtgac agtgccagcc aatgtgcaga     1020

ggtggatgag gtcttgtgaa aacctggctc cttttaacac ggccctcaag ctccttaagt     1080

gaattgccgt aactgatttt aaagggttta gattttaaga atggtgctct ttcatgccta     1140

ttatcagtaa ggggacttgt attagagtca gagtcttttt atttaggcca gttgtcaagt     1200

gtcaataaaa gcatcatgta attta                                           1225


<210> 213
<211> 640
<212> DNA
<213> Homo sapiens

<400> 213
gccggacgga cgctcgtctt cgcccgccat ggccgagagc gactgggaca cggtgacggt       60

gctgcgcaag aagggcccta cggccgccca ggccaaatcc aagcaggcta tcttagcggc      120

acagagacga ggagaagatg tggagacttc caagaaatgg gctgctggcc agaacaaaca      180

acattctatt accaagaaca cggccaagct ggaccgggag acagaggagc tgcaccatga      240

cagggtgacc ctggaggtgg gcaaggtgat ccagcaaggt cggcagagca aggggcttac      300

gcagaaggac ctggccacga aaatcaatga gaagccacag gtgatcgcgg actatgagag      360

cggacgggcc atacccaata accaggtgct tggcaaaatc gagcgggcca ttggcctcaa      420

gctccgggga aaggacattg gaaagcccat cgagaagggg cctagggcga aatgaacaca      480

aagcctcgaa atcagtgcgc tccagctgat ctcgttccgc cggttcccct tggccgccag      540

ttccgttctc ctcacgggcc gaacggaaca aggggtccag cttgcggggg accctcccca      600

gcccattcct gctgtcaaac aaacaaaacc ttgcaaagcg                            640


<210> 214
<211> 2212
<212> DNA
<213> Homo sapiens

<400> 214
gggcggcgcg ctgcattgtg gggtggcggc ggcggccgcg ctagcgacgc ggggccgggc       60

ggctgagcgt tcgcggggcc gaggccatgg ctttctgggc ggggggttcg cccagcgtcg      120

tggactattt ccctagcgag gacttctacc gctgcggcta ctgcaagaac gagtcgggca      180

gccgctccaa tggcatgtgg gcacattcca tgacagtaca ggattatcag gatctcatag      240

accgaggatg gcgaagaagt ggaaaatatg tgtacaaacc tgtcatgaat caaacatgtt      300

gtcctcagta cacaataagg tgccgacctt tacaatttca gccttcaaaa tctcacaaga      360

aggttttgaa aaaaatgttg aaatttctag ctaaagggga ggttcccaaa ggaagttgtg      420

aggatgagcc catggattcc acaatggatg atgctgttgc gggtgacttt gcattgataa      480

ataaactgga tatacagtgt gatcttaaaa cactcagtga tgacatcaaa gagagtttag      540

agagtgaagg aaaaaattca aagaaagaag aacctcagga attacttcag tcacaagatt      600

tcgtaggaga gaagttgggc tctggtgaac cgtcacattc agttaaagtt cacacagttc      660

ctaagccagg caaaggggct gatttgagta agcctccatg tcgaaaagca aaggaaatcc      720

ggaaagaaag gaaaaggtta aaactaatgc agcagaaccc agctggagaa cttgagggtt      780

tccaggctca aggtcaccca ccatctttgt ttccaccaaa ggctaaatcc aaccagccaa      840

aatcactcga agatttaatt tttgagtctt taccagagaa tgcatcacac aagttagagg      900

tgagggtggt gagatcatct ccaccaagtt cgcagttcaa agccacactt ctggagtctt      960

accaggtcta taaacgttac cagatggtta ttcacaagaa cccacctgat acgccaaccg     1020

aaagccagtt cacaagattc ctttgcagtt cacccttgga ggcagagact ccccctaatg     1080

ggccagattg tggctatggc tcctttcacc agcagtactg gcttgacgga aagatcattg     1140

ctgtgggggt gattgacatc ctcccaaact gtgtatcatc tgtgtatttg tactacgatc     1200

ctgattattc gtttttgtct ttgggcgtct actctgcact acgagaaatt gcttttacta     1260

ggcagcttca tgagaaaact tctcaactca gctattatta tatgggtttc tacattcatt     1320

catgtcccaa gatgaaatat aagggtcagt atagaccttc tgatttgctg tgccctgaga     1380

catatgtttg ggtacccatt gagcaatgcc tgccttcact tgaaaactcc aagtactgcc     1440

gtttcaacca ggacccagaa gcagtggatg aggatcgcag tacggaacct gaccgattgc     1500

aggtgtttca caagagagcc atcatgcctt acggtgttta taagaaacag cagaaagacc     1560

caagtgagga ggctgctgtt ctgcagtacg ccagcctggt ggggcagaag tgctccgagc     1620

ggatgctgct gttcagaaac tgacctgttc acctctgccg ggaagttcct gtgttgtgct     1680

gatgatttgt gccaggatac atattcagta cctgtgggga aataactgtc accacccaca     1740

aattagacat tttttatttt gactatctat ggcttttaaa aaatattttg tggcaatgta     1800

tctgtgagaa tctcatagtt aatataaaga ttttaaaact gcattatgac ctagccccca     1860

taattgggat ttatcatttt ggaggattct ttctagagca agatacgctc aaattctcct     1920

gtttgtattt tgtaaaatga agaagtgaat ctaagtaact taatcacagt tgtgcatttt     1980

ttttggttct gttagagaaa ttaaaacaga ctgtttcctc aggcccattt taaactgaac     2040

ttatgctagg aaaccttaag tatggggaag gtagaaagtt catttcatca cttagaaaat     2100

atgtcttctc aagaacaaaa ctgtgctgtt acaactcagt gttcaatgtg aaattgctgc     2160

caaatgttat gtagtttaat agagaacttg aaaaaataaa acattaaaat gg             2212


<210> 215
<211> 2362
<212> DNA
<213> Homo sapiens

<400> 215
tgtcctccca gctaccccct ccctaagcag gctgaggaag aagagatagc aagccctcac       60

ctaacttgac ccctttcttg tctctccccg ctgctagctt ctcccttctc gctgccttgc      120

ggggtgggga aacgtggaag gaattctggg aaaaccagat gtctgggttc tctattcccg      180

tctggcttga ttctggacaa ggggcttcct ctccagggcc tcggtttccc catctttaaa      240

atggactgat agcatagacc tgcccacctt tcagaggtgc ccgaagcctt gacgagataa      300

cagatgagaa gtggttttcg ttgtgatgag ccagctgaag cggttgcacc ggagcgccag      360

accgtcagcg gtgcagtggc tctcgcgtcc ttcacatccc cccacaccca tcccgtggat      420

gatgggggaa ggcactactc ctggggttcc ccgaagcgga tcctgggact gggacctggg      480

gacgcggtga gaggcagccc tgaagctgag tccagaggtc tggggcgtca ttgtcccagg      540

gcggacccag ccccagaccc tacaactaaa cccaaggcca gccgagaagc actaccactg      600

gcgggctgag ctgagctctc attcttctta ggactctgga cctttggagg aaatgaaagg      660

gacccagttg gaaatatagt ctttcttcgc gccccctaca tctctctccc ccggcggaaa      720

cgcggcccaa actgttacga agtggaagag gctggatagc tcttcataat taatcaggaa      780

tgggaggttt gagcaggttt acttgatgag ggaaacatta tagcctcgcc aattcattca      840

ttatttcaac aattacttat tgaacacctg ctacgtggca gacagtaaga gcctggatag      900

tttctccccg tttttcaaag tcgctaaacg cgaccagagg gcagaggaga ggccggtaac      960

ctaagagtcc tggctccgcc ccctccgcgt ttggccttgc ctgctcctcc caccaccact     1020

tcgctcagag gcggctactg gctcaagagg acgacagaag ccagtctctg atgcccaccg     1080

cattctccag cttcaggcct caagccctgt agccgagaag gcgaggccta atgttacacc     1140

accggtctgt tccgcctccg tttcggggtc cacccgaaaa gctttcagat cggatcctcg     1200

gtgagacggc actcgattaa ataggtctgt ctctacaggc caaggaggcg ggtttggtgc     1260

ggccactcca aggccaaagc gagaaaatct tactgcgcac gcgcaataga cagccgatgg     1320

agccaccgat ggagccgtcc ggaggggagc aagagcccgg agccgtcagg ttcctggacc     1380

tgccctggga agacgtgctg ctcccacacg tcctgaaccg ggtcccgctg cgccagctgc     1440

tccggctgca gcgcgttagc cgggccttcc ggtcgctggt gcagcttcac ctggccgggc     1500

tgcgtcgctt cgatgccgcg caggtgggtc cgcagatccc gcgggccgca ttggcccggc     1560

tgctgcggga tgccgagggg ctgcaggagc tggcactggc gccgtgtcac gaatggctgt     1620

cagacgagga cctggtgccg gtgctggcgc ggaatccgca gctgcggagt gtggcgttgg     1680

gcggctgcgg gcaactgagt cgccgggcgc ttggggcttt ggccgagggc tgcccacgcc     1740

tgcagcgcct gtcgctcgcg cactgtgact gggtggacgg gctggcgctg cgcggcctcg     1800

ctgatcgctg cccggccctg gaggagctgg atctcaccgc ctgccgccag ctcaaggacg     1860

aggccatcgt gtacctggcg cagaggcgcg gcgctggtct ccgcagcctc tctctggccg     1920

tcaacgccaa cgtgggggac gccgcggttc aagagttggc tcggaactgc ccagaactcc     1980

accaccttga cctcaccggc tgcctccgcg tcggaagcga cggtgtcagg acattggccg     2040

agtactgccc cgtgctgcgt tcgctgcggg tgcggcactg ccaccatgtg gcggagtcca     2100

gcctgagccg cttgcggaag cgcggcgtgg acatcgacgt ggagccgccg ctgcaccagg     2160

ccctggtgct gctgcaggat atggcgggct tcgcaccttt tgtcaacctg caggtctgac     2220

ccgcctgcca atcggagcac agctggactg tgtggctggg gcctgacact gagctgtagg     2280

gaaactgaac tgtgaggacc tctggtgaga ggccagtgcc ctgccccacc ctggagcttc     2340

aaataaagag ctttttaccc cc                                              2362


<210> 216
<211> 3501
<212> DNA
<213> Homo sapiens

<400> 216
gattggcagg cgactccccg cccctgcccc gcccccctgg gcgaagagcg cggacttgtg       60

gggccgctgg ctgcagactg gagctgcgcg ggtcagggag ataatggctg cgcggccgat      120

caccctcggc attgacctgg gcaccacatc tgtgaaggca gctctgctga gggccgcgcc      180

cgacgaccca tccgggttcg cagtgctggc gagctgtgcc cgtgctgcgc gggcagaggc      240

ggcggtcgag agcgcggtgg ccgggcccca ggggcgggag caggatgtga gtagaatcct      300

ccaagcccta cacgagtgcc ttgctgccct tccccgaccc cagctccgga gcgtcgtggg      360

catcggggtg tcgggccaga tgcatggagt cgtgttttgg aaaacaggcc aaggctgtga      420

atggacagag ggagggatta ccccggtgtt cgagccccga gctgttagcc acctggtcac      480

gtggcaggat ggccgatgta gcagcgaatt cctggcctct ctgccccagc cgaagtctca      540

tctcagtgtg gccacgggct tcggctgtgc aaccatcttc tggcttttga aatatcgccc      600

agagttcctg aagtcctacg acgcagccgg taccatccac gactatgtgg ttgccatgct      660

gtgtggcttg ccaagacctc tgatgtccga ccagaatgct gccagctggg gctatttcaa      720

cacgcagagc caaagctgga acgtagagac actgaggagc tcgggttttc ctgtccacct      780

gctcccagac atcgccgagc ctggcagtgt ggcgggcaga acttcccaca tgtggtttga      840

aatcccaaag gggacgcagg tgggagtggc cttgggtgat ttacaggcct ctgtctattc      900

ctgcatggcc cagaggacag atgcagttct caacatcagc acctcggttc agctggcagc      960

ctccatgcct tcaggattcc agcctgcaca gactccagac cctacggccc cagtcgccta     1020

cttcccatac ttcaacagga cctacctggg ggtggccgcg tcactcaacg ggggcaatgt     1080

gctggccacg ttcgtccaca tgctggttca gtggatggca gatctaggcc tggaggttga     1140

agaatccact gtgtattcac gcatgattca ggcagctgtg cagcagagag atacccacct     1200

gaccatcacc ccgacagtgc tgggggagag gcacctgccg gaccagctgg cctcagtgac     1260

cagaatctcc tcctccgacc tctccctggg gcacgtgacc cgggctctgt gccgaggcat     1320

tgttcagaac ctgcactcca tgcttccgat tcagcagctc caggactggg gcgtggagag     1380

ggtgatgggc agtgggagtg cgctgtccag gaatgacgtg ctgaagcagg aggtgcagag     1440

ggctttccct ttgcccatgt cctttgggca ggatgtggat gcagctgtcg gggcagctct     1500

ggtcatgctc cggagacacc tcaaccagaa ggaatcttag acagcaaact ctttcgccaa     1560

acgactgctg tgaattttac ctgattaaca ttcctgacac catctgtggg tcatcctttc     1620

cctggaccgt tcagtggaca gctttcaagc agtgcttgtt gtgaggtccc atctcggcca     1680

agaacttacc ttcagaacat actctaataa tgcagccagg agccgtcagc cagatcccaa     1740

atgagtgcct tccgaaattg acccacctgg gagctattta caaatgtcca tgtgggagag     1800

agagagcatg agagcacagt agcccagcct gctggtcagc aggctcatct gtggttcacc     1860

tgtagacaga gagcagatca atgtgtactt cagacaccag aaagtctggt ggctttggtc     1920

ccaagtggga aaagagaact gccccatgcc cagcttgtga ttatcgtttt tggagacctg     1980

aagcccacac tcgggtcgta tggacttctg gaaaagttct tgtctcctgg actgaaccat     2040

gtgaccggag gcccctttcc tagtctcatc ctcccctggc tgcagatgct tagctgggcc     2100

agggattgac ccaagcgcga tgcagcaggc aggctcagaa gacgatgcgg ggctgtgtgc     2160

cggccttctt gctgcatgta ctcagcctca ggagagcttg ctgcacccag gccgcccagg     2220

tcttcacagc acaactgcct ggaaggcagg ttgcgagaag gagaggcgga tggcatgagc     2280

agcaaggggg accgatgctg tgcagctcac accactccag aacctgacaa ggcaccagca     2340

ggaccccttg ccaggagcat gtctgtgcag cagtgttttt gcccctgcac attccagaag     2400

ccctcatggg aagggatgca gccaggcaga ctcctgccag atggggcagg tagtttattc     2460

aaagagaact ctgtatccca taggcccagg ctctcctttc gcttggcgtg ggctttgctg     2520

gcccagtgtg tgctcctggc tcagcagaaa catccatttg agttggcatc cctgtaggga     2580

tcccagagcg ttgtaagcct tcttgtgatt ggtagggatg gctgtggggt ggcttccagg     2640

agggggccac cattgccgca tctacttcta gactcccaaa ggagcccagg ctcaggcagg     2700

cctggcccag agtcacgctg gcaaccacga gtttgggaag cagtcgtatt ctctctctct     2760

ctctctctct ctctctcagt atccatgaca ggtatgaaac atattgtctc tttataaatg     2820

tcattttaca aattatgtga ttatctggaa gctctaagat gagagcaaat gcctgatcac     2880

tctggccaaa tgtcagatac taaagcccat tcttggccgg gcatgttggc tcccgcctgt     2940

aatcccagca ctttgggaag cccaagtggg tgaatcacct gaggtcagga gttcaagacc     3000

agcctgacca acatggggat accccgtctc tactaaaaat acaagccggg cgtggtggcg     3060

catgcctgta atcccagcta ctcaggaggc tgaggcagga aaatcacttg aactcgggag     3120

gcagaggttg cagtgagctg agatcgcgcc attgcactcc agcctgggtg acagagcaag     3180

actctgtctc ataaataaat acaaagccca ttcttccaga gtcttgtgcc ttaaataaaa     3240

cacacctctc tgctgtggga agactgtgca atggcacagc cgcagagctt ggtttgggag     3300

gttgaagtgc tctggggaga attcgtagat catcctcaga aaagccttgc cctggtgttc     3360

taccagaaaa acgtctccca atcacccagg aaagctgtcc acagtagtcc ccccttatcc     3420

acggtgtcac tttccatggg ttcagttatc tgcggtcaac cacggtctga caatattaaa     3480

tggaaaattc ttcaaacagt t                                               3501


<210> 217
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 217
agtggcgctc cggccagtga ttggctggag gtttgttaac tattcatgag ggggcgggcc       60

gagcggggcg gcctttgtta agcagcgagg gcgcgaccgc gggtactctg ctgccggctt      120

ctcggagcgg cgctgggcga ccagagcagg gtcgagatgt cctacatccc gggccagccg      180

gtcaccgccg tggtgcaaag agttgaaatt cacaagctgc gtcaaggtga gaacttaatc      240

ctgggtttca gcattggagg tggaatcgac caggatcctt cccagaatcc cttctctgaa      300

gacaagacgg acaagggtat ttatgtcaca cgggtgtctg aaggaggccc tgctgaaatc      360

gctgggctgc agattggaga caagatcatg caggtgaacg gctgggacat gaccatggtc      420

acacacgacc aggcccgcaa gcggctcacc aagcgctcgg aggaggtggt gcgtctgctg      480

gtgacgcggc agtcgctgca gaaggccgtg cagcagtcca tgctgtccta gcagccacca      540

ccatctgcga ctcctgcctg ccgcctctct gtacagtaac gccacttcca cactctgtcc      600

ccatctggct tctgctgacc gctgggcccc agctcagaag ggctatagct ggtcccagag      660

gcctggcctg gccttccttc ccttctccca tccctggcct ggggcctctg ggaccggctt      720

tctctcctgg acaccgagga ttggaaataa gggcctggag ctgagtagta gccagtctgc      780

tgtgaccaca ggctcaggtc cgaccctgct gcttggccac agcagtggct gggcaagtgg      840

gaaccactat ctcttgggag cccccaaaag ctgggaaatg ctggaggaac caggcctttc      900

ccgcttttgc ctggctgcag ggttcggctc tgcccctgcc ccccagccct cgtgtgtcca      960

caccgcagtg cctctgcccc tcgggggact ggacacacat cctgccagag gcgctacgaa     1020

gctttgccca gatgaagcca ggtgggctcc gcgttcactc ccactctccc gaggggtgct     1080

ggcctcccca gggtttgcct tcttacggat ttagacgagg ttcgaggctc acctatcagg     1140

gcagctctca ggattgtcat tttcctcttt gcctgtgggt ttaacttttg tattttttta     1200

atcacaagtt tgatacaaaa tgtttttatc gtactctttg gagatgccca ttctactttt     1260

gaatttagct tttactaatt cgcatctgga agctcagcaa gtgcacaagc cttactttgg     1320

ttaccgtgga aaccactgcc gcccctcccc gatgtggtgc gctcaataaa aatgctg        1377


<210> 218
<211> 2232
<212> DNA
<213> Homo sapiens

<400> 218
gaggcccatg gtgccgtgcg gcgggtcgtt gcgcctgcgc ggtgcgagcg gcgggcagcg       60

cagactgcga ggctcttttg ttcggctgag gggagggccg ttggccgggg cctgcggtac      120

gccgcttcag tgagggacgc cactgcggcc acccggcttg ctgccttcct gggcgccact      180

cccccaggcg acccgacgcg acgcgccagc agcgcagcac cgattcctct cgggctcttg      240

ggcgctgctc tgagcagcgt caccctttac accagaaagc tggcgggcac tatggggaaa      300

aaacaaaaca agaagaaagt ggaggaggtg ctagaagagg aggaagagga atatgtggtg      360

gaaaaagttc tcgaccgtcg agtggtaaag ggcaaagtgg agtacctcct aaagtggaag      420

ggattctcag atgaggacaa cacatgggag ccagaagaga acctggattg ccccgacctc      480

attgctgagt ttctgcagtc acagaaaaca gcacatgaga cagataaatc agagggaggc      540

aagcgcaaag ctgattctga ttctgaagat aagggagagg agagcaaacc aaagaagaag      600

aaagaagagt cagaaaagcc acgaggcttt gctcgaggtt tggagccgga gcggattatt      660

ggagctacag actccagtgg agagctcatg ttcctgatga aatggaaaaa ctctgatgag      720

gctgacctgg tccctgccaa ggaagccaat gtcaagtgcc cacaggttgt catatccttc      780

tatgaggaaa ggctgacgtg gcattcctac ccctcggagg atgatgacaa aaaagatgac      840

aagaactaac gctcctgagt accagcccct gtcacatctg actgtgggtt tcaagtggga      900

agggaaggag ttctacttgt cttgacacca tagaggtggc ttgagaagat gtcctttgaa      960

gagccagtat agtttctgtg ccctgcagca gcccaagtgc tttaaagccg tttcaagctg     1020

tatagtttgc acacccatcc cagtggaggg gaaaggggat aagtgtttca aggcaacctt     1080

ttctgcactt tgctgcgaaa agcaaagggc cttctatgaa ggacaaaact tgcagaattg     1140

ggtgtgtggg agagcaaaaa aatactgtag atcttcaaag agcatctcca caacccacag     1200

ccttcttccc aatagtgtta actctgcatt tttacagcgt agcatgtgtg tagtttttgg     1260

ctattactgg tgtattattt gggggaggga gggatgggga ggggagaaag ggagatgggt     1320

agcatcattt tgattaacat ttggggcctg ataggggaaa tggtgaagca atggaaaaga     1380

acagacaact aatgatttgc ttctatgtcc agaatatttt acctttaaaa aaatgtcatt     1440

ggcaccataa ataaggactg tgagagactg tttaaaagct gtgaaagtct gaaacctata     1500

agccaaggtg ttccctgcct aaacttattg ctgttcccac aaaggactaa gcctgttcat     1560

aagttaccaa agttgccatt ttggagatgg aaattgacga ggagggaagg tcttttattg     1620

gagagtatac agtacaagca gatcattctg ccttagaggt gctaattccc gaaattagaa     1680

gaccctttct tttccagtaa cgaagttata aatatcagct tgttcatcca agccactggc     1740

tgaggtgtta ggaagaggaa gagggtggta gaggaggtaa gacagtaggg aaagacaagg     1800

gcccatgctc ttagtgggga aaactcttgg agccgtttac tttgagcttt gaacactgaa     1860

accattgttg gcagggttca gtcactgaca gcacaagttt cactgaattg atccaagagt     1920

ttagtgattt caaaagcctt ggtctcagga gaagattaaa ctttcatatt gggcagtggt     1980

tcactttaaa acacacacat acacacacaa aacaattttt taagaaatcc taataagtaa     2040

catacccaaa atgctctgtc ttgagtcatg agaaccatca gttcttgata ttgtctagac     2100

ttgcatctag agctacgttg taaaattctt ttaggcatgt gttagatttc tgtgtaaact     2160

ttgtttaaat gtaaacttca tactacattg tcagtttttg tcttaataaa actatagatt     2220

tataatccct ga                                                         2232


<210> 219
<211> 2109
<212> DNA
<213> Homo sapiens

<400> 219
tcctatccac cctccactcc cctgtccctt ggtgactcat ccctgagctt cccaaggaag       60

cccccaccct ctgccctttc ctcccgcctt ccatgagtgg aaaatccacc tccgccccct      120

atagcaggcc agcccccttc ctccccagtc tccgacccca tcccccagcc gaccagtttc      180

ctctccagga ccagggagca atcacagctg ccccgacctt ggcttcctct gctgggtggg      240

attgggggct gggcccccaa atgggcccct ggcttccccc ttcctctggg caggggacag      300

agagacacag gctcggggag caggactgac ttcctcttgt cccggaatga gcatgcctgc      360

cctttgcaag caggtttggg tctcacgcag aggaaaccaa aagcaataag agggagggaa      420

ggcagagcaa ccaatcaagg gcagggtgag actcaaaacg agcgggctcc ctggggagcc      480

agacagaggc tgggggtgat ggcggagcta cagcagctgc aggagtttga gatccccact      540

ggccgggagg ctctgagggg caaccacagt gccctgctgc gggtcgctga ctactgcgag      600

gacaactatg tgcaggccac agacaagcgg aaggcgctgg aggagaccat ggccttcact      660

acccaggcac tggccagcgt ggcctaccag gtgggcaacc tggccgggca cactctgcgc      720

atgttggacc tgcagggggc cgccctgcgg caggtggaag cccgtgtaag cacgctgggc      780

cagatggtga acatgcatat ggagaaggtg gcccgaaggg agatcggcac cttagccact      840

gtccagcggc tgccccccgg ccagaaggtc atcgccccag agaacctacc ccctctcacg      900

ccctactgca ggagacccct caactttggc tgcctggacg acattggcca tgggatcaag      960

gacctcagca cgcagctgtc aagaacaggc accctgtctc gaaagagcat caaggcccct     1020

gccacacccg cctccgccac cttggggaga ccaccccgga ttcccgagcc agtgcacctg     1080

ccggtggtgc ccgacggcag actctccgcc gcctcctctg cgttttccct ggcctcggcc     1140

ggcagcgccg aaggtgtcgg tggggccccc acgcccaagg ggcaggcagc acctccagcc     1200

ccacctctcc ccagctcctt ggacccacct cctccaccag cagccgtcga ggtgttccag     1260

cggcctccca cgctggagga gttgtcccca cccccaccgg acgaagagct gcccctgcca     1320

ctggacctgc ctcctcctcc acccctggat ggagatgaat tggggctgcc tccaccccca     1380

ccaggatttg ggcctgatga gcccagctgg gtgcctgcct catacttgga gaaagtggtg     1440

acactgtacc catacaccag ccagaaggac aatgagctct ccttctctga gggcactgtc     1500

atctgtgtca ctcgccgcta ctccgatggc tggtgcgagg gcgtcagctc agaggggact     1560

ggattcttcc ctgggaacta tgtggagccc agctgctgac agcccagggc tctctgggca     1620

gctgatgtct gcactgagtg ggtttcatga gccccaagcc aaaaccagct ccagtcacag     1680

ctggactggg tctgcccacc tcttgggctg tgagctgtgt tctgtccttc ctcccatcgg     1740

agggagaagg ggtcctgggg agagagaatt tatccagagg cctgctgcag atggggaaga     1800

gctggaaacc aagaagtttg tcaacagagg acccctactc catgcaggac agggtctcct     1860

gctgcaagtc ccaactttga ataaaacaga tgatgtcctg tgactgcccc acagagataa     1920

ggggccagga gggattgaaa ggcatcccag ttctaaggct gctgctaatt acagccccca     1980

acctccaacc caccagctga cctagaagca gcatcttccc atttcctcag tacccacaaa     2040

gtgcagccca cattggaccc cagacacccc tctgcagcca ttgactgcaa cttgttcttt     2100

tgcccattg                                                             2109


<210> 220
<211> 854
<212> DNA
<213> Homo sapiens

<400> 220
gccaaatctt aaaggatccg ggagctaagc cagacccggg tggcggtggc agctgcgaaa       60

cccagggagc cgatgccacg tgacccaatg tggacttctt ttaaaccttt ctaatgccca      120

taacccagcc tcagacccat ggagcccacg agagactgcc cgctgttcgg gggcgccttt      180

tccgccatcc tccccatggg ggccattgac gtaagcgacc tccgaccggt cccggacaat      240

caagaagttt tctgccatcc cgtgacggac cagagcctga tagtggaact tctcgagctg      300

caggcccacg tacggggcga agcggctgcg cggtaccact ttgaggatgt tggtggcgtg      360

cagggggcta gggctgtcca tgtggagtct gttcagcctc tcagtttgga gaacctggcc      420

ctgaggggcc gctgtcaaga agcctgggtc ctctctggca agcagcagat agctaaggaa      480

aaccagcagg tagcaaagga cgtgacactt catcaggcct tgctgaggct gccccagtac      540

cagactgatc tcttgcttac cttcaatcag cccccccctg acaacaggtc atctcttggc      600

cccgaaaatc tgtcacctgc accctggagc ctgggtgact ttgaacagct ggtgaccagt      660

ctgacccttc acgatcctaa catctttggt ccccagtaaa ggcgctgaag cactgcatga      720

tgttgctgag aacttgggga ctcggttctg tgagggggaa aagaggttga aaagagggtt      780

tcctcttatt tcttccctgt gcgtaaacat aagacaatcc ctcttcagaa taaacttgct      840

ttataatcaa tata                                                        854


<210> 221
<211> 2213
<212> DNA
<213> Homo sapiens

<400> 221
gcgggcgcac acgaatgcgg gcgcacacga atgcgggcgc acacgaatgc gggcgcaccc       60

ttgagtcccc tccacaaccg cggtttgatc ccagcggtcc agtcggccgg tgctgcccat      120

ccgtcccgcc ccctagacgc acgtccgctc gcccggcgcc cgagccagtc cgcgcgcacg      180

ccgtctgcgc cccgaaagcc ccgccccaag gcgcgcccgc ccaccgctct ccacgtgctc      240

gctggagggc ggtgcgaggg gccgagccga caagatgttc ttgctgcctc ttccggctgc      300

ggggcgagta gtcgtccgac gtctggccgt gagacgtttc gggagccgga gtctctccac      360

cgcagacatg acgaagggcc ttgttttagg aatctattcc aaagaaaaag aagatgatgt      420

gccacagttc acaagtgcag gagagaattt tgataaattg ttagctggaa agctgagaga      480

gactttgaac atatctggac cacctctgaa ggcagggaag actcgaacct tttatggtct      540

gcatcaggac ttccccagcg tggtgctagt tggcctcggc aaaaaggcag ctggaatcga      600

cgaacaggaa aactggcatg aaggcaaaga aaacatcaga gctgctgttg cagcggggtg      660

caggcagatt caagacctgg agctctcgtc tgtggaggtg gatccctgtg gagacgctca      720

ggctgctgcg gagggagcgg tgcttggtct ctatgaatac gatgacctaa agcaaaaaaa      780

gaagatggct gtgtcggcaa agctctatgg aagtggggat caggaggcct ggcagaaagg      840

agtcctgttt gcttctgggc agaacttggc acgccaattg atggagacgc cagccaatga      900

gatgacgcca accagatttg ctgaaattat tgagaagaat ctcaaaagtg ctagtagtaa      960

aaccgaggtc catatcagac ccaagtcttg gattgaggaa caggcaatgg gatcattcct     1020

cagtgtggcc aaaggatctg acgagccccc agtcttcttg gaaattcact acaaaggcag     1080

ccccaatgca aacgaaccac ccctggtgtt tgttgggaaa ggaattacct ttgacagtgg     1140

tggtatctcc atcaaggctt ctgcaaatat ggacctcatg agggctgaca tgggaggagc     1200

tgcaactata tgctcagcca tcgtgtctgc tgcaaagctt aatttgccca ttaatattat     1260

aggtctggcc cctctttgtg aaaatatgcc cagcggcaag gccaacaagc cgggggatgt     1320

tgttagagcc aaaaacggga agaccatcca ggttgataac actgatgctg aggggaggct     1380

catactggct gatgcgctct gttacgcaca cacgtttaac ccgaaggtca tcctcaatgc     1440

cgccacctta acaggtgcca tggatgtagc tttgggatca ggtgccactg gggtctttac     1500

caattcatcc tggctctgga acaaactctt cgaggccagc attgaaacag gggaccgtgt     1560

ctggaggatg cctctcttcg aacattatac aagacaggtt gtagattgcc agcttgctga     1620

tgttaacaac attggaaaat acagatctgc aggagcatgt acagctgcag cattcctgaa     1680

agaattcgta actcatccta agtgggcaca tttagacata gcaggcgtga tgaccaacaa     1740

agatgaagtt ccctatctac ggaaaggcat gactgggagg cccacaagga ctctcattga     1800

gttcttactt cgtttcagtc aagacaatgc ttagttcaga tactcaaaaa tgtcttcact     1860

ctgtcttaaa ttggacagtt gaacttaaaa ggtttttgaa taaatggatg aaaatctttt     1920

aacggagaca aaggatggta tttaaaaatg tagaacacaa tgaaatttgt atgccttgat     1980

ttttttttca tttcacacaa agatttataa aggtaaagtt aatatcttac ttgataagga     2040

tttttaagat actctataaa tgattaaaat ttttagaact tcctaatcac ttttcagagt     2100

atatgttttt cattgagaag caaaattgta actcagattt gtgatgctag gaacatgagc     2160

aaactgaaaa ttactatgca cttgtcagaa acaataaatg caacttgttg tgc            2213


<210> 222
<211> 5771
<212> DNA
<213> Homo sapiens

<400> 222
gttttggcaa gggattaaag tgctcccccc tgtggcagca gtgacccaga aatgagtttg       60

attcacatag tccttcctcc ataacaagcc aaacgccaga ccgagagtgc ctccgtgcgc      120

gagtgcccgg tgtgtgcgcg ccggcgagag caggggcccg cccggctccc cgcccgccgc      180

ggcccgaact catgcagctc cgagcgagcg agcggcgccc agcccagcgc ctcggccgaa      240

cccctccgca gcaggctgcc tgctgtttcc cggggagatc atgaaacgag gtcgccttcc      300

cagcagcagt gaggattctg acgacaatgg cagcctgtca actacttggt cccagaattc      360

ccgatcccag cataggagaa gctcctgctc cagacatgaa gatcgaaagc cttcagaggt      420

gtttaggaca gacctgatca ctgccatgaa gttgcatgac tcctaccagc tgaatccgga      480

tgagtactat gtgttggcag atccctggag acaggaatgg gagaaagggg tccaggtgcc      540

tgtgagcccg gggaccatcc ctcagcctgt ggccagggtt gtgtctgaag agaaatccct      600

catgttcatc aggcccaaga agtacatcgt gtcatcaggc tctgagcctc ccgagttggg      660

ctatgtggac atccggacgc tggctgacag cgtgtgtcgc tatgacctca atgacatgga      720

tgctgcatgg ctggaactga ccaatgaaga atttaaggag atgggaatgc ctgaactaga      780

tgaatacacc atggagaggg tcctagagga atttgagcag cgatgctacg acaatatgaa      840

tcatgccata gagactgagg aaggcctggg gatcgaatat gatgaagatg ttgtctgtga      900

tgtctgccag tctcctgatg gtgaggacgg caatgagatg gtgttctgtg acaaatgcaa      960

catctgtgtg caccaggcct gttatggaat cctcaaggta ccagagggca gctggctgtg     1020

ccggacatgt gccctggggg ttcagccaaa atgtctgctg tgtccgaaga agggtggagc     1080

tatgaagccc acccgtagcg gaaccaagtg ggtccacgtt agctgtgctc tgtggatccc     1140

tgaggtgagc attggcagcc cagagaagat ggagcccatc accaaggtgt cacacattcc     1200

cagcagccgg tgggcgctag tgtgcagcct ctgcaatgag aagtttgggg cctctataca     1260

gtgctctgtg aagaactgcc gcacagcctt ccatgtgacc tgtgcttttg accggggcct     1320

ggagatgaag accatcttag cagagaatga tgaagtcaag ttcaagtcct attgcccaaa     1380

gcacagctca cataggaaac ccgaggagag tcttggcaag ggggctgcac aggagaatgg     1440

ggcccctgag tgttcccccc ggaatccgct ggagcccttt gccagccttg agcagaaccg     1500

ggaggaggcc caccgggtga gtgtccgtaa gcagaagctg cagcagttgg aggatgagtt     1560

ctacaccttc gtcaacctgc tggatgttgc cagggctctg cggctgcctg aggaagtagt     1620

ggatttcctg taccagtact ggaagttgaa gaggaaggtc aacttcaaca agcccctgat     1680

caccccaaag aaagatgaag aggacaatct agccaagcgg gagcaggatg tcttatttag     1740

gaggctgcag ctgttcacgc acctgcggca ggacctggag agggttcgga acctcactta     1800

catggtgacc cgcagggaaa agattaaacg gtctgtgtgc aaagtccagg aacagatatt     1860

caatctttac actaagcttt tggagcaaga aagagtttca ggtgtgcctt cttcctgctc     1920

ctcctcctca ctggaaaaca tgcttttgtt taacagtcct tctgttggcc ctgatgctcc     1980

caagatagag gacttgaagt ggcattctgc attcttcaga aaacaaatgg gtacttcctt     2040

ggttcattcg ctgaaaaagc cccataagcg agatcctttg cagaatagcc ctggaagtga     2100

aggcaaaacc ctgctgaagc agccagacct gtgtggtaga agggagggga tggtggtccc     2160

agagagcttt ttgggtttag aaaagacctt tgcagaagca cgtctcatat cagcacaaca     2220

gaaaaatggt gtggtgatgc cagaccatgg gaaaagaaga gacaatcgtt ttcattgtga     2280

tctcattaaa ggagacttaa aggacaaatc ttttaaacag agtcacaagc ctctcaggtc     2340

cacagatgtg tcccagaggc atctggacaa cacaagagct gccacctccc ctggagtggg     2400

gcagtcagca cctggcacaa ggaaggagat agtgcccaag tgcaatggct ccctaatcaa     2460

agtaaactat aatcagactg cagtcaaagt gcctacaaca cctgccagcc cagtgaaaaa     2520

ctggggagga ttccggattc caaagaaggg ggaacggcag cagcagggag aggcccacga     2580

tggggcctgc caccagcact cagactaccc atatttgggc ttaggccgag ttccagccaa     2640

ggaaagggca aaaagcaaat taaaatccga caatgagaat gacgggtatg tccccgatgt     2700

ggaaatgagt gactcagaga gtgaggcatc agaaaagaaa tgtatacaca ccagcagcac     2760

tatcagcaga aggacagaca ttatcaggag aagcatcttg gcttcttgat gcaacagaga     2820

tgatgcggaa gccctttggg ctcgtcattg ggtttgctag aggagagctc tgatgtgggg     2880

gagaagcaga aacccattaa tcctgagcta cacaaacaca tttacttgca attcagatta     2940

atttttttcc agagtcattt ttaaatcatt tttgtgagaa gtttgtgtta tttgcaactt     3000

gttgaggaaa cagaagagta gattgtaacc ataagacact gctaagacta gaacccgaac     3060

tgaacactaa aataaaaatg aaatgtttta aagaaggcaa ggcttaaata agcctcatga     3120

atttttatag ccctctgcat tcttcccaaa gcacaaactc atggttacct gaatataggg     3180

aaccagatat ggttcttgag aaaccctcat ggtaccattc acagcccata aagtttattt     3240

tctaggactg tggtagatct tgaaatcata tttatatttg gccctcaagg ctatttttgt     3300

tgcattatag catataggca gcagctctga agcttcagta acactaagaa atttatgtgt     3360

aaatatagca gtcagggaag agaattttaa aaaaggtcat tattgaagaa gctgagggga     3420

cagggtagag ctgctgcaat atggagattt agggtaatat ggcaaggtcc tgctgcttga     3480

agcctgtgag tgggttgtgg atatgggact ggtggagagt gagactgtta ggaaagttgt     3540

atctatgaat aagggcagtt gaagtagaat ttttaccagt ccacttgacc ttcttcttcc     3600

ctaaccactg gctcttgagc cagcttggga tttccctggc cattgccaat acctggccat     3660

ctggcttcca atagtacagt ggctactcaa gttcaagcga agaacttcca gactctggtg     3720

actgttactt cccagagcca accactagtg catatgttag ggaatctggg cttccaacat     3780

gaatggattc cttaagaaaa aggaaaaaaa aaaaaaaaag aaaaaaagaa aaaaaaaaga     3840

aaaaagaaaa aaagagaaaa aagcgaaata ggttatattt taaaaacaat agaaaggcaa     3900

taagttgcga taagctctta ctattgacca aggttataca ggaaagagac tgaagtgtac     3960

ccttgaatag gttttctgta gtcagagttc taaactctaa tttgtaactt ggactttcta     4020

attgcaaatg gcaataacta ttaagttatc agcaataata aatttagcat taaatttgag     4080

tacaatgttt tgtttttgca ctccccatag tgcgtatgta ttaagacagt ggatagtgtt     4140

taggtcctgt taattttctt tggaattcaa tgtggttgtg aatcaaactt aaggaaggaa     4200

cgtttaaata gcaatgagat acagaattat gggcctttgg aacaagcccg acttccccta     4260

aattctcctt agtttgttaa taccagtatt cagattcctg attcatttat acatctgttt     4320

ccatatggca gggacattat gatacttaat gaataatgct ttgaggagtt ctgcagttaa     4380

ctttcaagtc ttccagatga ttgtcaacaa caaaaaaggc ttattgaatc ccatcttgct     4440

atgcaagttt tatcagatga tcaaatagta gatctgatac atccccattg tatgtacgac     4500

attttcaaac caagtcttaa cttttcaagg acattttagt agctaattca ggggaggggg     4560

aagaatgatg caggttttta gattgactga ctatttttga gttatggggc tcattttgaa     4620

agactgctgt ccagatcagc ttgttgctgc agataataga aggttcttat gaatccaagt     4680

tgtatattca cttgtaggat aatttaaaaa ttagattttt tttgcatatg agcaaaaacc     4740

ttttgctgga tacaggagaa ggttggactt tatctacagt tatcttttga ttacagcaac     4800

agctctgggt gagagtagaa tttatagagg gataatttgt caagccatag aaagaaaatc     4860

taaattaatc tagtaagtgt atgacctctc accattttaa gaggtatcag attcatttgc     4920

actattagga atgctagttt tgtgcaaaaa taatgcctta cctgtttttt ccccacattt     4980

aggttgaaaa gctttcaaat gttccaagtt atgctgaacc aaaaaaaaca aaacaaaaac     5040

aaaacaaaaa atattaaaaa aaacccacac aaaaacaaaa cacacaaaaa taaaaagccc     5100

acacttttta ttcctgcttc gaaatgcaaa tggatagagc acggtttctc tgacagtata     5160

atgatagctt tgtgagttag tttcatgtca tgctgggaac tctctatgag gtggccataa     5220

gcagcaacca gcccaaacac ccacttgcgt tctattagta tggaaccatt tgcatttgtt     5280

ttttttaagc tttatctttc cttgtgcatc ctgaccaaga aatatctttg attatgatta     5340

atgtattatg tcaaaatgta ggctagttaa acttttgtaa agttgcctgg aatgtcattt     5400

gttaggttat aaacacaaga tctaaatgaa gggttttatg tgttgtgtac aaatcttatt     5460

ttgaaatgga caaacttgtc attacatttg taaccttgta cagaggattt ttcactatgt     5520

gcctagcttg gtgtccattc agctaaaatt gaaaaaaaaa aaaaggtgca tgaagagtta     5580

aaaatcaaat taaagtatat gtagagatga ctattttata ttacatgacc caatcctgta     5640

tttatttcta cccccttttt gaaagtattt ataaaactag ttgaggacag ctgtattttt     5700

ttgttgaact atttagtaga attgtgcctt tttgtctgta tgtgaataaa tgctgtacat     5760

tttgcaatac a                                                          5771


<210> 223
<211> 1780
<212> DNA
<213> Homo sapiens

<400> 223
caaatgcaga agtggttctc atcttttttt gcagcttaag atctgccttg gtatttgaag       60

agatataaac tagatcaatt tctttcacag gatcaactaa acagtgtacc acaatgaatt      120

ctgaacttga ctattatgaa aagtttgaag aagtccatgg gattctaatg tataaagatt      180

ttgtcaaata ttgggataat gtggaagcgt tccaggcaag accagatgat cttgtcattg      240

ccacctaccc taaatctggt acaacctggg ttagtgaaat tgtgtatatg atctataaag      300

agggtgatgt ggaaaagtgc aaagaagatg taatttttaa tcgaatacct ttcctggaat      360

gcagaaaaga aaacctcatg aatggagtaa aacaattaga tgagatgaat tctcctagaa      420

ttgtgaagac tcatttgcca cctgaacttc ttcctgcctc attttgggaa aaggattgta      480

agataatcta tctttgccgg aatgcaaagg atgtggctgt ttccttttat tatttctttc      540

taatggtggc tggtcatcca aatcctggat cctttccaga gtttgtggag aaattcatgc      600

aaggacaggt tccttatggt tcctggtata aacatgtaaa atcttggtgg gaaaagggaa      660

agagtccacg tgtactattt cttttctacg aagacctgaa agaggatatc agaaaagagg      720

tgataaaatt gatacatttc ctggaaagga agccatcaga ggagcttgtg gacaggatta      780

tacatcatac ttcgttccaa gagatgaaga acaatccatc cacaaattac acaacactgc      840

cagacgaaat tatgaaccag aaattgtcgc ccttcatgag aaagggaatt acaggagact      900

ggaaaaatca ctttacagta gccctgaatg aaaaatttga taaacattat gagcagcaaa      960

tgaaggaatc tacactgaag tttcgaactg agatctaaga aggtctttct ttacttaaca     1020

tatctgatat taaagatttc ttttcattat tctccacttt ttcttatttt agattgctag     1080

aaaagacata atcatggatt atgttgacat tttcttttta aatttttgtt taactttttt     1140

tttttttttt tgagacagag tctcactctg ttgcctaggc tggaggacag tggcacaatc     1200

atggctgatt gcagccttga cctccttgac tcaattgatc ctcccatctc agcctcccaa     1260

gtagctagga ctacagacat gtgcaaccat gtttggctaa tttttttaat gtttttttgt     1320

agagatgagg tcttattata ttgtccaggc tggtcttgaa ttcctgggct caagcttccc     1380

aagtagctgc aacaacaggc acacaccacc atgctcaact aattttattt ctattttttg     1440

tatagacagg ggcttgctat agtgtccagg ctggtctgaa acccttgagc tcaagtgatc     1500

ttcccacacc agcctcccaa aatactggga ttacaggctt gagcctccat gcctggccca     1560

ggtaacatgt ttattgagct gtacatgcat atgagaaata agaaactttt ttttcctact     1620

atcatctctt aaattttgtt ttctttttct tttgcttcct cttcttcttt tctatttttt     1680

ataaatatca tgcacaacta taacctatgg gaatgatgta gtaacacaga ttattcatct     1740

tgttagagtt gtattaaaaa taaacaagca tttcaaatta                           1780


<210> 224
<211> 853
<212> DNA
<213> Homo sapiens

<400> 224
ttttgcagtc ctcgcagcct cccgcgacct caggactggg ctgtactcgc cccttctcgg       60

ccgccgtagt tttttttttt ttttaaagaa aaaacggtta cccagcaact agaaaaacaa      120

ccggaaccgg cggcaccagc tcggagagaa aggaggttcc ataggcagtt cttaccaaga      180

agatgtcgat tccattctcc aacacccact accgaattcc acaaggattt gggaatcttc      240

ttgaagggct gacacgcgag attctgagag agcaaccgga caatatacca gcttttgcag      300

cagcctattt tgagagcctt ctagagaaaa gagagaaaac caactttgat ccagcagaat      360

gggggagtaa ggtagaagac cgcttctata acaatcatgc attcgaggag caagaaccac      420

ctgagaaaag tgatcctaaa caagaagagt ctcagatatc tgggaaggag gaagagacat      480

cagtcaccat cttagactct tctgaggaag ataaggaaaa agaagaggtt gctgctgtca      540

aaatccaagc tgccttccgg ggacacatag ccagagagga ggcaaagaaa atgaaaacaa      600

atagtcttca aaatgaggaa aaagaggaaa acaagtgagg acactggttt tacctccagg      660

aaacatgaaa aataatccaa atccatcaac cttcttatta atgtcatttc ttcctgagga      720

aggaagattt gatgttgtga aataacattc gttactgttg tgaaaatctg tcatgagcat      780

ttgtttaata agcataccat tgaaacatgc cacttgaaga tttctctgag atcatgagtt      840

tgtttacact tgt                                                         853


<210> 225
<211> 2645
<212> DNA
<213> Homo sapiens

<400> 225
gggtggggcc gcgagagcgg cggaagtagg aagccgaggt ctgaattgcg cgtggtggcc       60

atggcggcca gcggggctgt ggaaccaggg cccccggggg ctgccgtcgc cccgtcgccc      120

gccccggccc cgccgcctgc ccctgatcac ctgttccggc ccatcagcgc cgaggacgag      180

gagcagcagc ccaccgagat cgagtcgcta tgcatgaact gttactgcaa tggcatgacg      240

cgcctcctgc tcaccaagat tcccttcttc agagaaataa tagtgagctc cttttcctgc      300

gagcactgtg gctggaacaa cacggagatc cagtcggcag gcaggatcca ggaccaggga      360

gtgcgctaca ctttgtctgt cagggctctg gaggacatga acagagaagt ggtgaagact      420

gactctgctg ccacaaggat tcctgagcta gattttgaaa ttcctgcctt tagccagaaa      480

ggagctctga ccactgttga aggattgatc acccgtgcta tctctggcct ggagcaggac      540

cagcctgcac gaagggcaaa caaagatgct acagctgaaa gaattgatga gttcattgtc      600

aaactgaagg agctaaagca agtagcctcc cctttcactc tgatcattga tgatccctca      660

gggaacagtt ttgtggaaaa cccacatgct cctcagaaag atgatgccct ggtgatcaca      720

cactacaacc ggacccgaca gcaggaagag atgctggggc ttcaagaaga agcaccagca      780

gagaagccag aagaggaaga tctcagaaat gaagtgctcc agttcagcac aaactgccca      840

gaatgcaatg cccccgctca gaccaacatg aagctagtac aaatccctca ctttaaggag      900

gttatcatca tggctaccaa ctgcgagaac tgtgggcatc ggaccaatga ggtgaaatct      960

ggaggagcag tagaaccctt gggcaccagg atcaccctcc acatcacaga tgcctcagat     1020

atgaccagag acctcctcaa gtctgagact tgcagtgtgg aaatcccaga gctagaattt     1080

gaactgggaa tggcagtcct cgggggcaag ttcaccacac tggaagggct gctgaaagac     1140

atccgggaac tggtgaccaa aaatcctttc acactgggcg acagttccaa tcctggacag     1200

acggagagac tacaggagtt tagccagaag atggaccaga tcatcgaagg taacatgaag     1260

gcccacttta ttatggatga tccagcagga aacagttact tgcagaatgt gtatgcgcct     1320

gaagatgatc ctgagatgaa ggtggagcgt tacaagcgca cctttgacca aaatgaggag     1380

ctagggctca atgacatgaa gacagagggc tatgaggcag gcctggctcc gcaacggtag     1440

cagtgggtgg ctcaagggcc agcctccagc gctgctcttt ctgtaggtta tttattagta     1500

ttggatgaag gcgaaggctg ggagtgtctt tcccaccagc ccttgcccat ggtggggagg     1560

acatctggtc tgagtcagag atctgtgcac actttctaaa cagcttgtga tgcaagtgtg     1620

agcctattgt gttacttgac cttattttgg aagttttgaa ttggcctagg aggaaaccca     1680

gaaatgaacc aggggtatgt catcactttt ttcatatcaa gtcctcaccc tccttccaca     1740

taatgctcta tcctctaagg ttggaactct gaagttggag aaggtggaat aaagttacac     1800

ctggagtttg ttgttggttt tgagtatata aaatactgac tttgaacagg aaaggagtct     1860

cctgagggga gaccgagtcc agcacaagtg aaggagttac cattgaaatg atgactttca     1920

aacagcactg gcctctgtat tgaccctatc cttgtttgat atcatgctgt tagaattcag     1980

cctcctaaag aaaattttcc cgtgtatcta ctgtaatttg gggattgcag ctggcattta     2040

attcattcct tcagcagatg cttgcttatc tactttatgc caagcacacc acagaacaga     2100

ggacaaaata aatctctttc atggaacttg aagtctagtg gggaaaaatg acaataaaca     2160

gatcaggaaa acagtacatc agatggtgat tagtgtcatg gaggaatgta aagcagggaa     2220

tggggctggg ttgtgcaagg aaatggggag tagggaagat cttctgaaca agaaggtgat     2280

aatttgacat ttgggcaaag ctgaggagga ggtcagggag tgagctgtgt gggtatctgg     2340

gggaagagat ttcctggcag agggaactgc aaatgctaga gctgtgaggt tagagccagt     2400

gggggtacct gatcagttag ccctactctc agttagaaat gttgaaacac attcatccag     2460

agagaaagga ggctctctgc agttcttctg aaagttaagg accagtgaac actctgctgc     2520

ttgggccctg gacttcccag ccagtgttct ttgcactgta gtctcctgcc tctcataaac     2580

aaaaggtgac tcctgtggtg cagactgcag ggtatttgtt caataaagac cagttcattg     2640

attaa                                                                 2645


<210> 226
<211> 5642
<212> DNA
<213> Homo sapiens

<400> 226
ggcgcggtcg aggcccggag gcggcggcgc aggaggaagc ggaggaggtc gggcgctcgg       60

ggcccgggag gcgggccgcg cagcgccgca gccccgggct cgccatgctc ctggcctcgg      120

ccgtggtggt ctgggaatgg ctgaacgagc acggccgctg gcgtccctac agcccagcgg      180

tgagccacca catcgaggcg gtggtccgcg ccggcccccg cgcggggggc agcgtggtgc      240

tgggccaggt ggacagccgt ctcgcgccct acatcatcga cctgcagtcc atgaaccagt      300

tccgccaaga cacgggaact ctccgcccag ttcgccgcaa ctactacgac ccctcctcgg      360

cccctgggaa gggcgtggtg tgggagtggg agaacgacaa tggctcctgg acgccctacg      420

acatggaagt gggcatcacc atccagcatg cctatgagaa gcagcacccc tggatcgacc      480

tcacttccat tggctttagc tacgtaattg acttcaacac catgggccag atcaaccgtc      540

agacccagcg ccaacgccgc gtccgccggc gcctcgacct catctacccc atggtcacag      600

ggaccttgcc taaggctcag tcctggccag tcagccctgg gccagccacc tcgcccccca      660

tgtccccctg ctcctgtccc cagtgtgtct tggtgatgag tgttaaggca gccgtggtca      720

atggcagcac tgggccccta cagctgccag tgacccgcaa gaacatgccg cctcctggag      780

tggtcaagct acccccactg ccaggctctg gggccaagcc actggacagc acaggcacca      840

ttcgaggccc actgaagacc gccccatcgc aggtgatccg gagacaagcc tccagcatgc      900

ccactgggac aaccatgggc tctcctgcca gtcccccagg acccaacagc aagaccggaa      960

gggtggccct ggccaccttg aatcgtacca acctgcagcg actggccatt gcccagtccc     1020

gggtgctgat cgcctctggg gtccccacag tcccagtgaa gaacctaaat gggtccagtc     1080

ctgtcaaccc tgccttggca ggaatcactg ggatcctcat gagtgcagcg gggctgcctg     1140

tgtgtctcac caggccacca aagctggtcc tacacccacc ccccgtcagc aagagtgaaa     1200

taaaatccat cccaggggtt tccaacacaa gccgcaagac caccaaaaaa caagccaaga     1260

aaggtaaaac cccagaggaa gtgctaaaaa aatatctaca gaaagtccgg cacccaccag     1320

atgaggactg caccatctgt atggaacgcc tcacggcccc ctcaggctac aagggcccgc     1380

agcctacggt aaaacctgac ctggtaggga agctgtccag atgcggccac gtctaccaca     1440

tctactgctt ggttgccatg tacaacaatg ggaacaagga tggaagtttg cagtgtccaa     1500

cctgcaagac catttatggg gtgaagacag gcacccaacc tccagggaag atggagtacc     1560

acctcatccc ccactccttg cctggccacc cagactgcaa aaccatccgg atcatctaca     1620

gcatcccccc cggcattcag ggaccggaac acccgaatcc tgggaagagt ttcagcgccc     1680

gaggcttccc acgacactgt taccttccgg acagcgagaa agggagaaaa gttctgaagc     1740

tgctgctcgt ggcctgggat cgccgcctca tttttgccat tggcacctcc agcaccacag     1800

gcgagtcaga caccgtcatc tggaatgagg tccaccacaa gacagagttt ggctctaatc     1860

tcactggcca tggctaccca gatgccaatt acctggataa tgtgctggct gaactggctg     1920

cccagggcat ctctgaggac agcactgccc aggagaagga ctgaggccag aaaagctttg     1980

aggtgggagg ggccatggag actgcaggac aggaagtgag gagagtgagt caatgtagaa     2040

gaagttggtg tcctgccctc ccaactttct atcctcccct cctgccctgt gtccatccct     2100

catccctccc aaccacagtg ggagccagac tgaatatagc gacatcattc ataaatctca     2160

tccaacacaa agggagatgg gatgagggcc atcctgggtc tgttcccatg gagtttttgg     2220

tgctgggtag gcaggaatcc cctccctacc ccacctccca agtaggggca tggtcagcac     2280

acctagggta tgggcagtgc ttaggcactc catatcctgg ctttgggaag ccggggtttc     2340

ttgcctcagc cggcttcttg ctacttccac tctgctttga gactggagtt tctgctattc     2400

tccctctgct ggaggcaggg agctctcact gtgcaaggtt ggggggtggg caaaggggtg     2460

aatcactaaa ctgctgtgac atcagaaact gatgccttgg tgtagagcaa ggaagcactt     2520

cttcccaaga gggtcggaga aggaaaagcc tctgggagca cattctgctg tcatcacagt     2580

ccttggcttc tctgggccct cctctcctcc tcacagctct cacctgtcca aagaggcatc     2640

tggttctctc atgtggatgg atggactctg gggttcctct ttggagtggc atcccatgat     2700

gctgtttcta gaccctctct gatcaaacca gagcctgcat cccactgagc atctgaactg     2760

tcctcaggga gaggagccca cagccttctt cccaactcat tctagaccag ctcaaagatt     2820

ccatgagttt catcgagtca ctgtgagtgg agcccatgct gggctctgtg ccctctgtgt     2880

ctgtgcatgc gcgtgtgtgt gtgggcgtgt gtgcattgct gggccagctt gaagggaagg     2940

cccgtcatgt ccctgcactc tgttttgcaa gatgccaaac cccagttctg atggggctcc     3000

aacagccagg ctgtggtcct ttgacgttcc tcacctgttg ccaacctatc ccgtagtgaa     3060

ctgaaacccc aatgaagaca gaactgtgcc tggggagatg caatgaggtg agggctgaac     3120

tcatcctttt atatttcttt tcaagattgg atcagagctc atctccatcc agtcttgttt     3180

ctatgaaggc ttcaatctgt ttccatgcaa atttgctaat cagagcccag agctgctggg     3240

tccctcatct ccctcatcta ttatagattg acttacagca gggagagaat ctctttagct     3300

cattcctaat ggagttggga tcacaatatg gtctggtcca atctgcatct tgttgtgtcc     3360

caagacccta tctcctcccc aacattctta ttgcctttgg ctcccagtaa ggaacgaatt     3420

gggggccagg gaggagaaca ggggggatca agaagggaaa cccaattccc cctttgaaag     3480

tgggttcttt gaactatgtg tttgggggaa gttcctctgg atactaattt gaatttatat     3540

acctcatgtt ttgggggttt gacgtatata tatatatata tatatgcata tatatttcat     3600

aatatttgga aggtttttga tgctagaaaa atggaaacaa gagaaccttc aaaaatggta     3660

cttagatggg aactggaggc caatctttca taaagccagc cccatagctg cttgctgtta     3720

ggcctccagc cattttgaca ttggggtgga tagtcgattc acctgcctgt cagtcgattc     3780

acctgcctgt cacccagttc tgtggatgtg ctggtgctga gcctttgctc tctttccaaa     3840

tggttacagg gatgttgatc agctccacca gagggagctc tgatgggagg aattgctctg     3900

ccatccttgt ccctgtgtct cctgtcggca ggcagccatt gtatctcacc agcagaccag     3960

gagactggtc ccaaggttac tgcaccacag ggcaatttcc tgccatagtt aggaaggaaa     4020

cacctgaact aaatggaaga gacatccctg cggtgtttaa tatcacaccc atgccctttg     4080

tcaggttacc atgtacagag attacttgga gagcctcatg ccgtctctac cttcgcacac     4140

tggtcaagta tctgctgagc ttcttggccg caaggatgca gaaataggct gagggtccat     4200

gggaagaaag acacaatgag gcagtaggag gtggggaaga aaagaagaca gactttcaaa     4260

atggaattag gcactgggga gagatcagtt tccccacatc agggagaaga aggtataggt     4320

ggggaagggg gtggccagga gcagaaggaa gaagactcaa gatggaaagg gagccgctgt     4380

gcctgtggca ataccacttg gagaggtcga cttcatacct tcaagccttt tcccctgggc     4440

ttttgattgt gtctgtgccc cctttcttgt cctctctgca gatgcccagt aggggctacc     4500

tcatcctcgt gctgttcttg tgtggctttc tgggcagtag ggatcttgaa tttcctttct     4560

aacactgtgc ccggcaaggc ggggagcatt cctctgccct ttgtcttgtg ccaacctgga     4620

aaggtgcagt ctagatttca gtgagaaccc tgccagctga gccctgtgca tctactacct     4680

tgacacagag tgttttccca ctagaagctc tgctctgctc tcctggccca agtaggggat     4740

tccatgcctt ccctttcatg gtcttagcac cagcagccta gtttctccct tccagagtct     4800

ccagggatga caaattggat tggagacaaa cctcgtcaga tgctcatccc ctaaaaggtt     4860

aattgtgtat ttgtggctgc gtgtgccttt gtgttttcat tctcttccca tttttgtaca     4920

ttttggtctt ctctgtggtt ttatacttgg tcaaaagtac tcgtcttggt attgcactgt     4980

tgtgtgcatg agaaaactgg gggaaggctc actggtacaa gaaaggaccc ctgacccctt     5040

tccttctctg tggtccccgg cattagattg ggggttctgg gagaggcagg tgaatgtcct     5100

aagtgaattg ttctgtttgt aactggaatg tttttgaagt ctttggtgtt gctccgtgaa     5160

aggacatcgc cacctggtgc tcatgaggtg tctttgcaga acaataaatg gcaaatgaac     5220

aaccacaaaa ttgttactct tgttggcctt ctgctgtttg tagattagtg cacctatctg     5280

tgagggattt gggttacctc cctgagtctg taagcaacca caagccctgc cactgggtgg     5340

gggaagtccc tccccaacca cttaaaaaca aattttccac atattaccca cccacacatt     5400

tgacctggct agactttgtt tgcctaaagg aacagaccac attgctggga aaatgagtaa     5460

gtgaacgtgt gggagaaaaa cacttttaga atcacgaata ttcactttta aaggtctctt     5520

tgcctggctg caatatagtg tgtgtttaaa ttatttacag gctgttgttt ctcaaataaa     5580

tgtttaatat taatcattcc caaactgaca agaacacaaa aataaaatgc aaatacagag     5640

cc                                                                    5642


<210> 227
<211> 1014
<212> DNA
<213> Homo sapiens

<400> 227
agaagcggaa ctgcaaggcc ggaagctcca cgtccgcacc cgccccttcc gtttcgcttc       60

cgcctacctc gcccaggctg ccagaccgga agcgctccgc tgtacctgga tcctgctcct      120

ctgggttgaa acccgggcgc cgccaagatg ccggcttacc actcttctct catggatcct      180

gataccaaac tcatcggaaa catggcactg ttgcctatca gaagtcaatt caaaggacct      240

gcccccagag agacaaaaga tacagatatt gtggatgaag ccatctatta cttcaaggcc      300

aatgtcttct tcaaaaacta tgaaattaag aatgaagctg ataggacctt gatatatata      360

actctctaca tttctgaatg tctgaagaaa ctgcaaaagt gcaattccaa aagccaaggt      420

gagaaagaaa tgtatacgct gggaatcact aattttccca ttcctggaga gcctggtttt      480

ccacttaacg caatttatgc caaacctgca aacaaacagg aagatgaagt gatgagagcc      540

tatttacaac agctaaggca agagactgga ctgagacttt gtgagaaagt tttcgaccct      600

cagaatgata aacccagcaa gtggtggact tgctttgtga agagacagtt catgaacaag      660

agtctttcag gacctggaca gtgaagggag cccgggcagc caccgtctcc agagccctgg      720

gcagcatttt ccagcaagat gtacacaatc ttttgccttt atttcgtaaa gttttataca      780

gaagagagaa gagcatgtct ttacttgaaa aactcttgat caagaatttg ggtgggagaa      840

aagaaagtgg gttatcaagg gtgatttgaa attttctgca gcattaaagc tggcgcttaa      900

taagaataag taataataaa gaaatttcta acattccatg tcagaaaaac tttattgcca      960

gtctttgaca ttcacttaca atttgttttg agataaaatt cacattccat aatg           1014


<210> 228
<211> 3019
<212> DNA
<213> Homo sapiens

<400> 228
ggtacatgga aggccacagg aagaaacaag atcttgagct gagcaagaac atcccagcat       60

cttcattgac tttaaaagta tattctggag tcttccgtgg ttcactattc cagtactaca      120

gagattcctt atattacatg gcaggagggg ggtaaactga gggatagtga agacaacaat      180

aaattaatca agagctttcc tcatatctca gaacctatcc tctgtaagaa tgtcagaaaa      240

ggttgactgg ttacaaagcc aaaatggagt atgcaaagtt gatgtctatt ctcctggaga      300

caaccaagcc caggactgga aaatggacac ctccacggat cctgtcagag tgctcagctg      360

gctccgcaga gacctggaga agagtacagc agagttccaa gatgttcggt tcaaacccgg      420

agaatcattt ggtggggaaa cgtccaactc aggagaccca cacaaaggtt tctctgtaga      480

ctattacaac accaccacca agggcactcc agaaagattg cattttgaga tgactcacaa      540

agagattcct tgccagggcc ccagggccca acttggcaac gggagttcag tagatgaagt      600

ttccttctat gctaaccgcc tcacgaatct agtcatagcc atggcccgca aagagatcaa      660

tgagaagatc gatggctctg aaaacaaatg tgtctatcag tcattgtaca tggggaatga      720

acccacaccc accaaaagcc tcagtaagat agcatcagag cttgtgaatg agaccgtctc      780

tgcatgttcc aggaatgctg ccccagacaa ggctcctggc tctggagaca gagtctcggg      840

atcatcacaa agtcccccaa atttgaaata caagtccact ttgaagatca aggagagcac      900

caaagaaaga cagggtccag atgacaagcc tccttctaag aagtctttct tctataagga      960

agtgtttgaa tctcgtaatg gagattatgc cagagagggt ggaaggttct ttcctcggga     1020

gagaaagagg tttcgagggc aggaaaggcc tgatgacttt acggcttctg ttagtgaagg     1080

gatcatgacc tatgctaaca gtgtggtatc tgatatgatg gtctccatca tgaagacact     1140

gaagatccaa gtgaaagaca caaccattgc caccatccta ctgaagaagg ttctgctcaa     1200

gcatgcaaaa gaggtggtct cggatctcat cgactccttc ttgaggaatc tccacagcgt     1260

cacagggacc ctcatgactg acacacagtt tgtctcggct gtgaaaagaa ctgtcttctc     1320

tcatggaagc caaaaggcca cagatatcat ggatgccatg ctaaggaagc tgtacaatgt     1380

aatgtttgcc aagaaagtcc ctgagcatgt caggaaagcc caagacaagg ctgagagtta     1440

ttccctcatc tccatgaaag gaatgggtga tcctaaaaac cgaaatgtga actttgccat     1500

gaaatctgaa actaaattga gagaaaaaat gtattctgaa cccaaatcag aggaggagac     1560

ttgtgcgaaa actctgggtg agcacattat caaagagggg cttaccttgt ggcataaaac     1620

tcagcagaaa gaatgtaaat ctctaggttt ccagcatgca gcatttgaag ctcccaacac     1680

acagcgtaag cctgcatcag acatttcctt tgagtaccct gaagatattg gcaacctcag     1740

ccttcctcca tatcctccag agaaacctga gaattttatg tatgattcag actcctgggc     1800

cgaggacctg atcgtgtctg ccctgcttct gattcaatat cacctggccc agggaggaag     1860

aagggatgca cggagcttcg ttgaagctgc tggcaccacc aactttcctg ccaatgaacc     1920

tcctgtagct cccgatgaat cttgccttaa gtctgctccc attgtaggtg accaagaaca     1980

agcagaaaag aaggacctaa ggagtgtttt ctttaatttc atccggaact tacttagtga     2040

gaccattttc aagcgtgacc agagccctga acccaaggtg ccggaacagc cagttaagga     2100

agataggaag ttgtgtgaaa gaccgttggc gtcttctccc cccaggctat atgaggatga     2160

tgagacccct ggtgcccttt ctgggctgac caagatggct gtcagccaga tagatggcca     2220

catgagtggg cagatggtag aacatctgat gaactcagtg atgaagctgt gtgtcatcat     2280

tgctaagtcc tgtgatgctt cgttggcaga gctgggagat gacaagtctg gagatgccag     2340

taggctaact tcggccttcc cagatagttt atatgagtgc ttaccagcca agggcacagg     2400

gtcagcagaa gctgtcctgc agaatgccta tcaagctatc cataatgaaa tgagaggcac     2460

atcaggacag ccccctgaag ggtgtgcagc acccacggtg attgtcagca atcacaacct     2520

aacggacaca gttcagaaca agcaactcca agccgtcctt caatgggtag ctgcctctga     2580

gctcaatgtc cctattttgt attttgctgg tgatgatgaa gggatccagg agaagctact     2640

tcagctctca gctgctgctg tggacaaagg atgcagtgtg ggcgaggttc tgcagtcggt     2700

gctgcgctat gagaaggagc gccagctgaa tgaggcggtg gggaatgtca caccgctgca     2760

gctgctggac tggctgatgg tgaacctgta atcggcaacc ccactgcttt cccctcttct     2820

ggcagtgggg ccggccctta tccccgccct tctttctcac ttccacatct ccccctctat     2880

atcctcacag agccctaaca ttatcttcac accactctca tcaaagacat gtcatcttgt     2940

gctagccact ggattttgca gattttcctg tccatgcaag caaggacgta aaattaaaaa     3000

attacaatta aagggctcc                                                  3019


<210> 229
<211> 3568
<212> DNA
<213> Homo sapiens

<400> 229
ggaagagaaa gagtgaagaa aagttgcgag cgtctcctct cttcctaagc ctcccgcccc       60

aacccacccc tcagagaagg agaagataat atactgaaaa gaagaggagg aggagagcga      120

cgggacggga cgcgagcggg agcgcagccg ccctctcggc tccgcggcgg cgcctcgcaa      180

gtccgggagg cgaggggggc ccgaggggag acgccgtgac aactttcgtt tccctctgag      240

ggaattggga ggtcggcggc cccaaaagct ttcagtccag tgtaaagctg ttggagcgcg      300

ggagcaaagg taaagaatga tgtaatgcgc tggctgctcc aaagcatctt ttgttgtgga      360

atggttattc cagtcatctc tttatgaatc aaatgtgagg ggctgctttg tggacggagt      420

cctttgcaag agcacatcaa cgggaaagag aaagagacat tcacttggag ggctcttgct      480

gaaaatgggt ttaactctcc ttttgccagt caccaccagc ctgacctcat acacttttag      540

tacaatggag tggctgagcc tttgagcaca ccaccattac atcatcgtgg caaattaaag      600

aaggaggtgg gaaaagagga cttattgttg tcatggccca tgagatgatt ggaactcaaa      660

ttgttactga gaggttggtg gctctgctgg aaagtggaac ggaaaaagtg ctgctaattg      720

atagccggcc atttgtggaa tacaatacat cccacatttt ggaagccatt aatatcaact      780

gctccaagct tatgaagcga aggttgcaac aggacaaagt gttaattaca gagctcatcc      840

agcattcagc gaaacataag gttgacattg attgcagtca gaaggttgta gtttacgatc      900

aaagctccca agatgttgcc tctctctctt cagactgttt tctcactgta cttctgggta      960

aactggagaa gagcttcaac tctgttcacc tgcttgcagg tgggtttgct gagttctctc     1020

gttgtttccc tggcctctgt gaaggaaaat ccactctagt ccctacctgc atttctcagc     1080

cttgcttacc tgttgccaac attgggccaa cccgaattct tcccaatctt tatcttggct     1140

gccagcgaga tgtcctcaac aaggagctga tgcagcagaa tgggattggt tatgtgttaa     1200

atgccagcaa tacctgtcca aagcctgact ttatccccga gtctcatttc ctgcgtgtgc     1260

ctgtgaatga cagcttttgt gagaaaattt tgccgtggtt ggacaaatca gtagatttca     1320

ttgagaaagc aaaagcctcc aatggatgtg ttctagtgca ctgtttagct gggatctccc     1380

gctccgccac catcgctatc gcctacatca tgaagaggat ggacatgtct ttagatgaag     1440

cttacagatt tgtgaaagaa aaaagaccta ctatatctcc aaacttcaat tttctgggcc     1500

aactcctgga ctatgagaag aagattaaga accagactgg agcatcaggg ccaaagagca     1560

aactcaagct gctgcacctg gagaagccaa atgaacctgt ccctgctgtc tcagagggtg     1620

gacagaaaag cgagacgccc ctcagtccac cctgtgccga ctctgctacc tcagaggcag     1680

caggacaaag gcccgtgcat cccgccagcg tgcccagcgt gcccagcgtg cagccgtcgc     1740

tgttagagga cagcccgctg gtacaggcgc tcagtgggct gcacctgtcc gcagacaggc     1800

tggaagacag caataagctc aagcgttcct tctctctgga tatcaaatca gtttcatatt     1860

cagccagcat ggcagcatcc ttacatggct tctcctcatc agaagatgct ttggaatact     1920

acaaaccttc cactactctg gatgggacca acaagctatg ccagttctcc cctgttcagg     1980

aactatcgga gcagactccc gaaaccagtc ctgataagga ggaagccagc atccccaaga     2040

agctgcagac cgccaggcct tcagacagcc agagcaagcg attgcattcg gtcagaacca     2100

gcagcagtgg caccgcccag aggtcccttt tatctccact gcatcgaagt gggagcgtgg     2160

aggacaatta ccacaccagc ttccttttcg gcctttccac cagccagcag cacctcacga     2220

agtctgctgg cctgggcctt aagggctggc actcggatat cttggccccc cagacctcta     2280

ccccttccct gaccagcagc tggtattttg ccacagagtc ctcacacttc tactctgcct     2340

cagccatcta cggaggcagt gccagttact ctgcctacag ctgcagccag ctgcccactt     2400

gcggagacca agtctattct gtgcgcaggc ggcagaagcc aagtgacaga gctgactcgc     2460

ggcggagctg gcatgaagag agcccctttg aaaagcagtt taaacgcaga agctgccaaa     2520

tggaatttgg agagagcatc atgtcagaga acaggtcacg ggaagagctg gggaaagtgg     2580

gcagtcagtc tagcttttcg ggcagcatgg aaatcattga ggtctcctga gaagaaagac     2640

acttgtgact tctatagaca attttttttt cttgttcaca aaaaaattcc ctgtaaatct     2700

gaaatatata tatgtacata catatatatt tttggaaaat ggagctatgg tgtaaaagca     2760

acaggtggat caacccagtt gttactctct taacatctgc atttgagaga tcagctaata     2820

cttctctcaa caaaaatgga agggcagatg ctagaatccc ccctagacgg aggaaaacca     2880

ttttattcag tgaattacac atcctcttgt tcttaaaaaa gcaagtgtct ttggtgttgg     2940

aggacaaaat cccctaccat tttcacgttg tgctactaag agatctcaaa tattagtctt     3000

tgtccggacc cttccatagt acaccttagc gctgagactg agccagcttg ggggtcaggt     3060

aggtagaccc tgttagggac agagcctagt ggtaaatcca agagaaatga tcctatccaa     3120

agctgattca caaacccacg ctcacctgac agccgaggga cacgagcatc actctgctgg     3180

acggaccatt aggggccttg ccaaggtcta ccttagagca aacccagtac ctcagacagg     3240

aaagtcgggg ctttgaccac taccatatct ggtagcccat tttctaggca ttgtgaatag     3300

gtaggtagct agtcacactt ttcagaccaa ttcaaactgt ctatgcacaa aattcccgtg     3360

ggcctagatg gagataattt ttttttcttc tcagctttat gaagagaagg gaaactgtct     3420

aggattcagc tgaaccacca ggaacctggc aacatcacga tttaagctaa ggttgggagg     3480

ctaacgagtc tacctccctc tttgtaaatc aaagaattgt ttaaaatggg attgtcaatc     3540

ctttaaataa agatgaactt ggtttcaa                                        3568


<210> 230
<211> 1721
<212> DNA
<213> Homo sapiens

<400> 230
ggtggcagga aaggcttgga acagctgccg gaggtgacgg agcggcggcc ccgcccggtg       60

cgctggaggt cgaagcttcc agctctggac atcctgagcc caagtccccc acactcagtg      120

cagtgatgag tgcggaagtg aaggtgacag ggcagaacca ggagcaattt ctgctcctag      180

ccaagtcggc caagggggca gcgctggcca cactcatcca tcaggtgctg gaggcccctg      240

gtgtctacgt gtttggagaa ctgctggaca tgcccaatgt tagagagctg gctgagagtg      300

actttgcctc taccttccgg ctgctcacag tgtttgctta tgggacatac gctgactact      360

tagctgaagc ccggaatctt cctccactaa cagaggctca gaagaataag cttcgacacc      420

tctcagttgt caccctggct gctaaagtaa agtgtatccc atatgcagtg ttgctggagg      480

ctcttgccct gcgtaatgtg cggcagctgg aagaccttgt gattgaggct gtgtatgctg      540

acgtgcttcg tggctccctg gaccagcgca accagcggct cgaggttgac tacagcatcg      600

ggcgggacat ccagcgccag gacctcagtg ccattgcccg aaccctgcag gaatggtgtg      660

tgggctgtga ggtcgtgctg tcaggcattg aggagcaggt gagccgtgcc aaccaacaca      720

aggagcagca gctgggcctg aagcagcaga ttgagagtga ggttgccaac cttaaaaaaa      780

ccattaaagt tacgacggca gcagcagccg cagccacatc tcaggaccct gagcaacacc      840

tgactgagct gagggaacca gctcctggca ccaaccagcg ccagcccagc aagaaagcct      900

caaagggcaa ggggctccga gggagcgcca agatttggtc caagtcgaat tgaaaggact      960

gtcgtttcct ccctggggat gtggggtccc agctgcctgc ctgcctctta ggagtcctca     1020

gagagccttc tgtgcccctg gccagctgat aatcctaggt tcatgaccct tcacctcccc     1080

taaccccaaa catagatcac accttctcta gggaggaggc aaatgtaggt catgtttttg     1140

ttggtacttt ctgttttttg tgacttcatg tgttccattg ctccccgctg ccatgctctc     1200

tcccttgttt ccttaagagc tcagcatctg tccctgttca ttacatgtca ttgagtaggt     1260

gggtagccct gatgggggtc gctctgtctg gagcataacc cacaggcgtt ttttctgcca     1320

ccccatccct gcatgcctga tccccagttc ctatacccta cccctgacct attgagcagc     1380

ctctgaagag ccatagggcc cccaccttta ctcacaccct gagaattctg ggagccagtc     1440

tgccatgcca ggagtcactg gacatgttca tcctagaatc ctgtcacact acagtcattt     1500

cttttcctct ctctggccct tgggtcctgg gaatgctgct gcttcaaccc cagagcctaa     1560

gaatggcagc cgtttcttaa catgttgaga gatgattctt tcttggccct ggccatctcg     1620

ggaagcttga tggcaatcct ggaagggttt aatctccttt tgtgagtttg gtggggaagg     1680

gaagggtata tagattgtat taaaaaaaaa aaggtatata t                         1721


<210> 231
<211> 2924
<212> DNA
<213> Homo sapiens

<400> 231
agggccccgc cctgccttct ggggcaaagc ggagagtggt cggttctgcc ccacagtaac       60

gcgaggaaag aaatctcgcg aggctggagt tctccgggag cgccggtcgg aggcggtcgg      120

cggaggtgtc taccccgccg gtgatggcgt tgaacgccac tggcttcccg gccttccgtc      180

cgctgcctcc gtccgattct gcgtctgctt gctgaggagg cggattaggg gggcgcggag      240

tctcttccct tgagtgcata ggtcccggtt ggtagagggt ttgagtccgc atcgccacag      300

ctgaaggctg cgagggacta agagcagaat atatctttag aaatgagttg cacaattgag      360

aaggcacttg ccgacgctaa agctcttgtt gaaagattaa gagatcatga cgatgcagca      420

gaatctctga ttgagcaaac cacagctctc aacaagcgag tagaagccat gaaacagtat      480

caggaagaaa ttcaagaact taatgaagtc gcgagacatc ggccacggtc cacgttagtt      540

atgggaatcc agcaagaaaa cagacaaatc agagagttgc aacaagaaaa caaagaatta      600

cgtacatctc tggaagaaca tcagtcggcc ttggaactta taatgagcaa gtaccgagaa      660

caaatgttta gattgctaat ggctagcaaa aaagatgatc cgggtataat aatgaagtta      720

aaagagcagc actccaagat tgacatggta catcgtaaca agtccgaagg attcttcctt      780

gatgcatctc gacacatcct tgaagcacct caacatggac tggagagaag gcacttggaa      840

gcaaatcaga atgaactgca agcacatgtt gaccagataa ctgaaatggc agcagtaatg      900

aggaaagcca ttgaaattga cgagcaacag ggttgcaagg aacaagaacg aatatttcaa      960

cttgaacaag aaaacaaagg cttgagagag atccttcaaa taactcgaga atcatttttg     1020

aacctaagga aagatgatgc gtcggaaagt acttctttgt cagcattagt gaccaacagt     1080

gatttgagtc tgaggaagag ctgaagagtt tctgagtctg tgagcttctt acatggctcc     1140

aaatggtcaa ataagtgaat gaatgaatgg acagaaaatt caatccttta tttttttctc     1200

tgtaaatatg tacagtgcac gggctatgag atagcaacaa aaaatgcata gttaatggtc     1260

atagacttta ttccaaaaca taattggaaa atagaaactg agccattgcc aaatggtaaa     1320

gaaatgaaaa gttttcacag tgactactga atataccaag agcttttggc agtactgctg     1380

gctttctggg tgattaatta ggtaaacttg aatattccca gtaaatgttt gagaatgcat     1440

aaaattatac caatttaaaa atataaattt ttgccactgt tttgtgaacg gaggatttgt     1500

acgctaaatt tcatccttat ttggcgtcaa agttgatgca aagtttatgt accatgagac     1560

ttctagtgat tgcctacttt cacatttatt taaatttttg tgaaagaaaa tacagtttta     1620

aaggctatag gaatgtgtta tatgtacctt aaacagataa tttaatttta gcaatttatc     1680

ataactgata cttagctaac aattgtccat aacttgttta agtgtaagaa ataccatttc     1740

aggaatgaaa aagaaggaat actactttct aagaaagaag atcttataat agacatattt     1800

agtaggttaa actactcctt tgaaagaata agttttggtt caaagtcaat aatgaagacg     1860

agatttgttt ttctcttctc tggctgattt ttaaggatat tatgtagttc atttagttaa     1920

cagaattgaa atgtttgata tggcaagata ggtatggtaa tttcaaagtg aattgggaat     1980

tcctctggct catagaaccc tttttttttt cctttaagta ttcttgagat acaaaaaaaa     2040

aaagtaaata caatttcaaa aaaaaagttc cggatctgtt tttaagctcc atctggtcct     2100

cataacctgc aagatttttc ttaaaacctt tcagctgaaa gtgggggtaa aggtggagta     2160

atctgtggat ttgtttctgt tgtcttttaa aatgtcaaat atataatatg taattttttt     2220

aaaaaccacc agatacagaa atgtgcttta acatcagttg aaacctaaat tttcttatgt     2280

tgtggtgatt gtattaaaaa gggataaaag aagagtgtca aacatggtta aatatattgt     2340

actcatttat gttgaatacg tattaaaatt aagacaaatg gaaaattata ctttgagtat     2400

ataatttgtt aaatattact ttatatggta attttatgta taatttcata tattggtaaa     2460

attcaaaact acacttgaga atttttttat cttaagtttg gggtgaatgg ggtggatgag     2520

actgattgaa tagaaaaggg ctaatggccc aaacattata tagatttctt tttttcagtc     2580

agaggcctta tttgatattt tataaataaa tgacagtttt tatttttaaa ctttttattg     2640

tttttgggaa agtattcctt aatttaatga cacattcatt cagatacttc ttatccctgc     2700

taataaagga aatctatttc aagctacacc attgagatta agtctgaggc agttcattga     2760

ggcagctcta ctataaaagc ttacttgata aataattatt tttgtaaaca agttgggtta     2820

acttattctt cgtctttttg cttggatatg aatttaaggt cttcatgttt aaagacattt     2880

actttgttat ttagtgacac atttccatcc tatttttttt tttt                      2924


<210> 232
<211> 715
<212> DNA
<213> Homo sapiens

<400> 232
aaagtcagtg agcaaatcgc ggaccaccgg ggctgccagc tcgcctgact cccggcctct       60

tgcgctccta ggggcggaga agggtgcggg ctcttcgccc tttgtgtcct ccttctttca      120

ctaacttctg gactttccag ctcttccgaa gttcgttctt gcgcaaagcc caaaggctgg      180

aaaaccgtcc acgatgacca gcatgactca gtctctgcgg gaggtgataa aggccatgac      240

caaggctcgc aattttgaga gagttttggg aaagattact cttgtctctg ctgctcctgg      300

gaaagtgatt tgtgaaatga aagtagaaga agagcatacc aatgcaatag gcactctcca      360

cggcggtttg acagccacgt tagtagataa catatcaaca atggctctgc tatgcacgga      420

aaggggagca cccggagtca gtgtcgatat gaacataacg tacatgtcac ctgcaaaatt      480

aggagaagat atagtgatta cagcacatgt tctgaagcaa ggaaaaacac ttgcatttac      540

ctctgtggat ctgaccaaca aggccacagg aaaattaata gcacaaggaa gacacacaaa      600

acacctggga aactgagaga acagcagaat gacctaaaga aacccaacaa tgaatatcaa      660

gtatagattt gactcaaaca attgtaattt ttgaaataaa ctagcaaaac cagaa           715


<210> 233
<211> 1262
<212> DNA
<213> Homo sapiens

<400> 233
tcagttggtc acgtggttgt tcggagcggg cgagcggagt tagcagggct ttactgcaga       60

gcgcgccggg cactccagcg accgtgggga tcagcgtagg tgagctgtgg ccttttgcga      120

ggtgctgcag ccatagctac gtgcgttcgc tacgaggatt gagcgtctcc acccagtaag      180

tgggcaagag gcggcaggaa gtgggtacgc aggggcgcaa ggcgcacagc ctctagacga      240

ctcgctttcc ctccggccaa cctctgaagc cgcgtcctac tttgacagct gcagggccgc      300

ggcctggtct tctgtgcttc accatctaca taatgaatcc cagtatgaag cagaaacaag      360

aagaaatcaa agagaatata aagaatagtt ctgtcccaag aagaactctg aagatgattc      420

agccttctgc atctggatct cttgttggaa gagaaaatga gctgtccgca ggcttgtcca      480

aaaggaaaca tcggaatgac cacttaacat ctacaacttc cagccctggg gttattgtcc      540

cagaatctag tgaaaataaa aatcttggag gagtcaccca ggagtcattt gatcttatga      600

ttaaagaaaa tccatcctct cagtattgga aggaagtggc agaaaaacgg agaaaggcgc      660

tgtatgaagc acttaaggaa aatgagaaac ttcataaaga aattgaacaa aaggacaatg      720

aaattgcccg cctgaaaaag gagaataaag aactggcaga agtagcagaa catgtacagt      780

atatggcaga gctaatagag agactgaatg gtgaacctct ggataatttt gaatcactgg      840

ataatcagga atttgattct gaagaagaaa ctgttgagga ttctctagtg gaagactcag      900

aaattggcac gtgtgctgaa ggaactgtat cttcctctac ggatgcaaag ccatgtatat      960

gaaatgcatt aatatttgac tgttgagaat tttactgccg aagtttacct ccactagttc     1020

tttgtagcag agtacataac tacataatgc caactctgga atcaaatttc cttgtttgaa     1080

tcctgggacc ctattgcatt aaagtacaaa tactatgtat ttttaatcta tgatggttta     1140

tgtgaatagg attttctcag ttgtcagcca tgacttatgt ttattactaa ataaacttca     1200

aactcctgtt gaacattgtg tataacttag aataatgaaa tataaggagt atgtgtagaa     1260

aa                                                                    1262


<210> 234
<211> 657
<212> DNA
<213> Homo sapiens

<400> 234
ggcgccggag agcgcgggcg gctggggaat ggctgctgcc atggtgccgg ggcgcagcga       60

gagctgggag cgcggggagc ctggccgccc ggccctgtac ttctgcggga gcattcgcgg      120

cggacgcgag gacaggacgc tgtacgagcg gatcgtgtct cggctgcggc gattcgggac      180

agtgctcacc gagcacgtgg cggccgccga gctgggcgcg cgcggggaag aggctgctgg      240

gggtgacagg ctcatccatg agcaggacct ggagtggctg cagcaggcgg acgtggtcgt      300

ggcagaagtg acacagccat ccttgggtgt aggctatgag ctgggccggg ccgtggcctt      360

taacaagcgg atcctgtgcc tgttccgccc gcagtctggc cgcgtgcttt cggccatgat      420

ccggggagca gcagatggct ctcggttcca ggtgtgggac tatgaggagg gagaggtgga      480

ggccctgctg gatcgatact tcgaggctga tcctccaggg caggtggctg cctcccctga      540

cccaaccact tgacttaatc tcactttctt aaattcttct attctcagac actgctctag      600

taccattcct tcctcttagc cccaggagca aattaaaagg tacagttaaa atcctaa         657


<210> 235
<211> 3492
<212> DNA
<213> Homo sapiens

<400> 235
cgggaagact gcatccggct ccaggaaaag cgagtgggat atcccaatct ttggactgca       60

tcctggttgc ctctactgtg gtcacctttg ggaagaaatg tcttctgtaa aaagaagtct      120

gaagcaagaa atagttactc agtttcactg ttcagctgct gaaggagata ttgccaagtt      180

aacaggaata ctcagtcatt ctccatctct tctcaatgaa acttctgaaa atggctggac      240

tgctttaatg tatgcggcaa ggaatgggca cccagagata gtccaatttc tgcttgagaa      300

agggtgtgac agatcaattg tcaataaatc aaggcagact gcactggaca ttgctgtatt      360

ttggggttat aagcatatag ctaatttact agctactgct aaaggtggga agaagccttg      420

gttcctaacg aatgaagtgg aagaatgtga aaattatttt agcaaaacac tactggaccg      480

gaaaagtgaa aagagaaata attctgactg gctgctagct aaagaaagcc atccagccac      540

agtttttatt cttttctcag atttaaatcc cttggttact ctaggtggca ataaagaaag      600

tttccaacag ccagaagtta ggctttgtca gctgaactac acagatataa aggattattt      660

ggcccagcct gagaagatca ccttgatttt tcttggagta gaacttgaaa taaaagacaa      720

actacttaat tatgctggtg aagtcccgag agaggaggaa gatggattgg ttgcctggtt      780

tgctctaggt atagatccta ttgctgctga agaattcaag caaagacatg aaaattgtta      840

ctttcttcat cctcctatgc cagcccttct gcaattgaaa gaaaaagaag ctggggttgt      900

agctcaagca agatctgttc ttgcctggca cagtcgatac aagttttgcc caacctgtgg      960

aaatgcaact aaaattgaag aaggtggcta taagagatta tgtttaaaag aagactgtcc     1020

tagtctcaat ggcgtccata atacctcata cccaagagtt gatccagtag taatcatgca     1080

agttattcat ccagatggga ccaaatgcct tttaggcagg cagaaaagat ttcccccagg     1140

catgtttact tgccttgctg gatttattga gcctggagag acaatagaag atgctgttag     1200

gagagaagta gaagaggaaa gtggagtcaa agttggccat gttcagtatg ttgcttgtca     1260

accatggcca atgccttcct ccttaatgat tggttgctta gctctagcag tgtctacaga     1320

aattaaagtt gacaagaatg aaatagagga tgcccgctgg ttcactagag aacaggtcct     1380

ggatgttctg accaaaggga agcagcaggc attctttgtg ccaccaagcc gagctattgc     1440

acatcaatta atcaaacact ggattagaat aaatcctaat ctctaaatct aagaactaag     1500

ctttgagtat tatttaataa tttctaataa cactcattcc tcaagtgata ttagagatta     1560

ttcagtactc ttgagagtgt cacaacacaa aatacgatgt tgggttttcg aaatattttc     1620

aaagtgttct gtcttaatca caaattcata tttttacaca tttttacaat attgcctcag     1680

attatgttaa atttgggtca gtcttctctg aactttttct ctcttggttt cttttcttcc     1740

ttcacagttt tatctcacaa aaccattttt ctaataagag acatcatgtt ggaaagatgt     1800

tctagaaatg tgcataaatt tcagtgcctc ttgtaagcat taaactgatg atgaagaaag     1860

ttcctgattt gagaaatgaa tcaaagtaat tttaatgaat ttttagcttg tattagcttg     1920

agttagctgg cattgatttt ttagtccttt tgttaccttt aagttgtcaa tatatggttt     1980

ttgttcatct ccccattgta gtcccacttg ctctttcctg ggggttccat tgttctagca     2040

gtggaggtgt tatagtgtcg ccactcgtct aatttgacca gtgttaagaa ttttctaatt     2100

taataattta atagtgatct caataccaca ccctcatgga aggagaaaag catactatta     2160

tatctgggac ctctctttta gacctaaaat taattaacat atctacttat atgttactta     2220

tacctaaagc tgttattaag acaaaccaag attctctgct tttgcactga aattaaactt     2280

gaaaggaatt ctcctcaaag gtcggatatt aaataagtcc caggcagatt tacatattta     2340

atttaaaaca ttggctttat ttcattttgt gatgagtgat gtatctgtgt taacaaaaaa     2400

ttgtataatc attaccaata ctatttatta tgctcaaata tatcttggct ttgaccttat     2460

ttcaacacat tctaagaagc cttgacaaag taagtatatt ttagagctga atcagtaaga     2520

ttctagagaa agcaaaacat agtagttcac aattttgcaa catagaaagt cacattttga     2580

aaggctattt tgaaattgat ttaatagcta ttatagttta tgaatatcaa aatttgtata     2640

atttgcatct ttactaatgt atgctagagc tacaagagac cttaaggata atatatgaaa     2700

ttagctttcc ttattttata gataaggaaa aagaaattgt gaaaggtgaa tttacctaat     2760

tagtgaaagt tacataacta attacaacag tctgtactat ataatgcaga ggacgattct     2820

ccctgtaaaa ggaactagaa gctattacta aaaatatata tagacaaaat taaaagaagg     2880

aatgataaga ataaatttaa tttaccaaat attgttaatt aaaattttag atacttaaca     2940

tttatttaac ttaaataaaa gataactgtc agataaaact ttattttact aatgagcagt     3000

gattttctta ggaattgatg aaggcttatt ggtatcaaga atttaaacca aattaaaact     3060

gacagaggac atttagatac ataataaaat tcgagctaca taagtatatg gaaaataatg     3120

taccttgatt attatgaaat agagcatctt gaaattcagt tttactctaa atgtactttt     3180

aatacttgca gattctaaga ttacattgta aaattccagg ttttcataat gttaaaatag     3240

gaaagtagaa tataaagtat caacaagtgt agttatacat tttgttttgg atatttaatc     3300

cttacttggg aaaaaatcag catctaggta aattattatt ttaataacaa ctcttaaatt     3360

gccaacctct gagaggtgaa aagctatgta aatagaagga atggccagtt caaaagaata     3420

gtagatgtga tagtgccgtg aatgtattct actggaaatg aatgtaataa tacattaaat     3480

ttttaaaatc ta                                                         3492


<210> 236
<211> 1738
<212> DNA
<213> Homo sapiens

<400> 236
gcggtcttat ataagccaga tccgcagggg agtccgcaga agggttaaac aggtctttgg       60

gcttcggcga cctcgcccgc ggcagaaacc ggtaagaaga cagtgggctg cgcgtctcat      120

tttcagcctt gcccggactc tcccaaagcc ggcgcccagt agtggctcca gagcccacag      180

gtggcccccg gcagtctctg gggcgcatgg agcggcgtta atagggctgg cggcgcaggc      240

cagtagccgc tccaacatga acctcgtggg cagctacgca caccatcacc accatcacca      300

cccgcaccct gcgcacccca tgctccacga acccttcctc ttcggtccgg cctcgcgctg      360

tcatcaggaa aggccctact tccagagctg gctgctgagc ccggctgacg ctgccccgga      420

cttccctgcg ggcgggccgc cgcccgcggc cgctgcagcc gccaccgcct atggtcctga      480

cgccaggcct gggcagagcc ccgggcggct ggaggcgctt ggcggccgtc ttggccggcg      540

gaaaggctca ggacccaaga aggagcggag acgcactgag agcattaaca gcgcattcgc      600

ggagttgcgc gagtgcatcc ccaacgtgcc ggccgacacc aagctctcca agatcaagac      660

tctgcgccta gccaccagct acatcgccta cctgatggac gtgctggcca aggatgcaca      720

gtctggcgat cccgaggcct tcaaggctga actcaagaag gcggatggcg gccgtgagag      780

caagcggaaa agggagctgc agcagcacga aggttttcct cctgccctgg gcccagtcga      840

gaagaggatt aaaggacgca ccggctggcc gcagcaagtc tgggcgctgg agttaaacca      900

gtgagccgag gcccgcgccg aggacctggc caggccagcc actcctgaag ccccgggagg      960

agaggaaggc agcggcgaac gccaggctct gggctccggc gactggtgct acgcatcccg     1020

cggagcttct gctgagcgcc ggcaggtcgt cggctgcaac cacacacttg gatcgcacgt     1080

gcaatgtcct ttgatttttt ttaatacatt aagagaaaga gaaatatata tatatccacc     1140

cccagcccaa ccgagggcgg cccttggcgg caacatgcaa gaaggaggga ctgtcgaacc     1200

caagggctca aagacgcact cttccaccct tttggagcga atttagaacc tcagccctat     1260

ctccatttcc ctatctggct ctttctctct tgtccctcca tatgatccgc cccgacgccg     1320

tcttctctaa ttaaaatgca ataaggaatc aattcttttc tgcctgagaa agagaaccag     1380

acgcaggaag atgaaaggct gccctttgtt cttcgaatcg tggtggtttt attttatttt     1440

tctttttgtc gctgcacttc ctgtttagtt ccaagggaaa cactttctct ctttctctgt     1500

ctctctcttt tcttccttct tttccttcct ttttgtttct atctaaataa aagctttccc     1560

tgtgttggaa agtttttatg tatttaaact acctaccatg cctgttgtgc tcaggtgttt     1620

gttcatcctg ccatccccaa cccttttcta cctcaagtct gtgtgaccac tcacagcccc     1680

cctcccttcg ccaaagcagt gtctatgctc ttgattaata aaacattttc tgaaatca       1738


<210> 237
<211> 3107
<212> DNA
<213> Homo sapiens

<400> 237
aagaccagca gataaaaaat aatttttaaa aacctcgtga gactgatttg ccgcaggacg       60

ggaggaggaa gaagcaagcg tggaaggtgc taacggagga acctaaacct ccatcctctt      120

tgcctgggag gttaagaact acagggagag gcgagagaga ctatgactgc cctacggcta      180

gagtagccgc gaagagaaca cttccggggc ggggctatct ggccctttcc tttccgcgtg      240

tagaatgtgg ggcgcctgta aagttaaggt tcacgattcc ttggccacca tttccatcac      300

tctgagacgg tacctgagat tgggggcgac catggcaaaa agcaagttcg agtacgtgag      360

ggacttcgag gctgacgaca cctgcctggc acactgctgg gtggtagtgc ggctggacgg      420

ccggaatttc catcggtttg ctgagaagca caactttgca aaacccaatg acagccgtgc      480

tctccagctg atgaccaaat gtgcgcagac tgtgatggaa gaactagagg atattgtgat      540

cgcgtatgga cagagtgatg agtacagctt tgtgttcaag cggaaaacca attggtttaa      600

aagaagagcc agtaagttca tgactcacgt ggcctcccag tttgcctcca gctatgtgtt      660

ttattggcgg gattactttg aggaccagcc ccttctgtat cccccaggct ttgacggaag      720

agtcgtggtg tatcccagca accagacttt aaaggactac ctcagctggc gacaagcaga      780

ttgtcacatc aataatcttt ataatacagt tttctgggca cttatacaac aatctggact      840

aacaccagta caagcccaag ggagattaca gggaactctt gcagcagaca agaatgagat      900

tttgttttct gaattcaaca tcaactataa taatgagctg ccgatgtata ggaaagggac      960

tgtgttgata tggcagaagg tggatgaagt gatgacaaaa gaaattaagc tgccaacaga     1020

aatggaagga aaaaagatgg cagtgacccg gaccaggaca aagccagtgc ccttgcactg     1080

cgatatcatc ggggatgctt tctggaagga acatccagag attctagatg aagacagctg     1140

acccttttgc gcttcagttc tggtgtgctt aaccatgcaa gccctcccac ctcccagggc     1200

tccttgcctt aggtggctgt agcatcccta ccacccagga cactggtgcg aatgacacaa     1260

ctcaagttgg gaggggaaca gggaaggaag ggatggatgg gggtggtgta tcttactctg     1320

tttaagcaga acaccttgtt tgcggtgttg gaacatggtt cctttggcag aagtgctttt     1380

tttttaatcg cagtactatt tttataaagc aagaactatt ccatgccttg gagaatgaat     1440

catttttaga ttgtgacata aatcttgtaa aaacctgtca gttattttca tctatgagag     1500

aagaggagcc caaactctcg cccacctgtt cttaaccaga aaacccactg actttgaaaa     1560

tctcacctct gccacccatc tacttgcatt cgtctttggc agacctcaag ataaatatgg     1620

gttaatgcct gcatgatgcc tctgaattca ggaattgcag ggaaaactcg gggctttgtg     1680

ccagtctcta agttggcaac tttggctgaa caaatgagta gtggcttcag tgtccttgcg     1740

tacacattct gtggattgat ttaatggagt tgtcagcatg atcatcatct tctagccagg     1800

ggcatagttg ccaaggccat ttacctcttt ctaagaagaa acagaattat gtgtatatat     1860

gagagaaaga aacaagaatg cgtgaatgag gatgaagaaa catttacccc atgtactcaa     1920

gacatttcag ttttaaaagt cactttccta ttagacttct tgaaaaacat tctcacatag     1980

cctctatgta atcagacaaa tgacatttga tttcaagagc agaggggtaa acatcctctg     2040

ctaatcgaca ggtagcaggt gtcagaggag gcataatatt aatagcgcca ccttctgttg     2100

ggtcagtgga gatgggtgag gaacagcaca gagcagcagg gatcatcaca tgcagccaaa     2160

cttggcctct gaagggggaa ggtagtggga ataggtggtg agagaactca catttttctc     2220

ttgtcctggt tttatatttc ggagggaaag gattatttgg ccccattaag aattaagagg     2280

ctgggtgcgg tggctcacgt ctgtaatccc agcaccttgg gaggcccagg caggcagatc     2340

acctgaggtc gggagttcga gaccagcgtg accaacgtgg agaaaccccc gtctctacta     2400

aaaatacaaa aaattagctg ggcatggtgg tgcatgcctg tgattccagc tacttgggag     2460

gttgaggcag gagaatcatt tgaactcagg aggcggaagt tgcggtgagc caagattgtg     2520

ccattgcact ccagcctggg caacgagcga aactacatct caaaaaaaaa aaaaaaagac     2580

atggctgggc atggtggctc acacctgtaa tcccagcact ttggggggct gaggcaggta     2640

gatcacttca ggccaggagt ccaagaccag cacgtccaac atggcaaaac ccagtctgta     2700

ctaaaaatag aaaaattagc tgggcgtggt ggcgtgtgcc tgcaatacca gctactcaga     2760

aggctgaagc aggataattg cttgaacctg gtaggtggag gttgcagtga gctgaaatca     2820

tgccactgca ctccagcctg ggtgacagag caaaactgcc ttaaaaaaaa aaattaagag     2880

acagcccgtg tcccagtccc tcgtcttgca ctgcagaatt tacatctaag aagaaaatgt     2940

atttttgaaa gggtgatggc tggcctcatc cctcactaat tgacaaccca tctgtcgatg     3000

ccattttttc ccttcctgtt ctcactccac agaaagagga gatacggttc ttgtttggta     3060

attgctaaaa tctctttgag gaaagaaata aagatgtcaa ctccttt                   3107


<210> 238
<211> 4186
<212> DNA
<213> Homo sapiens

<400> 238
agatgcccgt accccctcac cgccctcagt tcacgccctg gctggtttgg attcgagagg       60

aaaaatcatt aaaggatctg gagttttcac cccaaaactt taatcgtttt gtcccttctt      120

tttttttctt gtctttcctc cagcagctgc agactacata atgaaaaata acaaaagtgc      180

ccatgcgcga ggctgtgcaa ctaaccaccc gacgattgcg gggaggagga gtaagagtcg      240

gctaagcggc gcccagtgtc ctactgcgcc tgtgcgccgg tggcgtgcgc agaggcctct      300

gggtaggtgg ctcaaccccg cctctcagtt gaggactctg aaggctgttt ctgtggcgct      360

tcccctgcga ggatggctac cctggttgta aacaagctcg gagcgggagt agacagtggc      420

cggcagggca gccgggggac agctgtagtg aaggtgctag agtgtggagt ttgtgaagat      480

gtcttttctt tgcaaggaga caaagttccc cgtcttttgc tttgtggcca taccgtctgt      540

catgactgtc tcactcgcct acctcttcat ggaagagcaa tccgttgccc atttgatcga      600

caagtaacag acctaggtga ttcaggtgtc tggggattga aaaaaaattt tgctttattg      660

gagcttttgg aacgactgca gaatgggcct attggtcagt atggagctgc agaagaatcc      720

attgggatat ctggagagag catcattcgt tgtgatgaag atgaagctca ccttgcctct      780

gtatattgca ctgtgtgtgc aactcatttg tgctctgagt gttctcaagt tactcattct      840

acaaagacat tagcaaagca caggcgagtt cctctagctg ataaacctca tgagaaaact      900

atgtgctctc agcaccaggt gcatgccatt gagtttgttt gcttggaaga aggttgtcaa      960

actagcccac tcatgtgctg tgtctgcaaa gaatatggaa aacaccaggg tcacaagcat     1020

tcagtattgg aaccagaagc taatcagatc cgagcatcaa ttttagatat ggctcactgc     1080

atacggacct tcacagagga aatctcagat tattccagaa aattagttgg aattgtgcag     1140

cacattgaag gaggagaaca aatcgtggaa gatggaattg gaatggctca cacagaacat     1200

gtaccaggga ctgcagagaa tgcccggtca tgtattcgag cttattttta tgatctacat     1260

gaaactctgt gtcgtcaaga agaaatggct ctaagtgttg ttgatgctca tgttcgtgaa     1320

aaattgattt ggctcaggca gcaacaagaa gatatgacta ttttgttgtc agaggtttct     1380

gcagcctgcc tccactgtga aaagactttg cagcaggatg attgtagagt tgtcttggca     1440

aaacaggaaa ttacaaggtt actggaaaca ttgcagaaac agcagcagca gtttacagaa     1500

gttgcagatc acattcagtt ggatgccagc atccctgtca cttttacaaa ggataatcga     1560

gttcacattg gaccaaaaat ggaaattcgg gtcgttacgt taggattgga tggtgctgga     1620

aaaactacta tcttgtttaa gttaaaacag gatgaattca tgcagcccat tccaacaatt     1680

ggttttaacg tggaaactgt agaatataaa aatctaaaat tcactatttg ggatgtaggt     1740

ggaaaacaca aattaagacc attgtggaaa cattattacc tcaatactca agctgttgtg     1800

tttgttgtag atagcagtca tagagacaga attagtgaag cacacagcga acttgcaaag     1860

ttgttaacgg aaaaagaact ccgagatgct ctgctcctga tttttgctaa caaacaggat     1920

gttgctggag cactgtcagt agaagaaatc actgaactac tcagtctcca taaattatgc     1980

tgtggccgta gctggtatat tcagggctgt gatgctcgaa gtggtatggg actgtatgaa     2040

gggttggact ggctctcacg gcaacttgta gctgctggag tattggatgt tgcttgattt     2100

taaaggcagc agttgtttga agttttgtgg ttaaaagtaa ctttgcacat agtatgtttt     2160

aagaaattat acatctcaaa agatggtaat ttaggatgca tatatatata tatatatata     2220

aaggaatctt ggattgggaa ttcagtactt tgctttaaaa aaattttgtg gcagaattaa     2280

atttctaatt gagcagatta gattgaatta aatagaaact tattgaatat acattctttt     2340

aaaaagtata tttgttattt aagtttttca gataatatgt gaccaatata ctgggaaaga     2400

ggtagtcaca gagaaagggt aagtgaaggt ttattctttc agtgaaaaaa gaatagccaa     2460

ttgagtgcct aatgagacct ctgtgtgaag caagtgaagt atagctgctt cttttaacct     2520

gccttttcac tgaatgttgg cagcatttag tagtagaaat gacagttgct taatgaaata     2580

gaatccaaac tacatatttg gataatagga ttactttatg tttatgttca gagttaacag     2640

aacaccttta atgctaagaa ctataaggta cagaaaatta atactttata tagtgtttta     2700

ttaactttct cctacagcat tttgtataaa acacaatgag ggagtgaaat gttacccaat     2760

taggcttgtc aggttagtaa taaactgaac agtaataaaa ctgtggaagt aattggatct     2820

gaatttatga aagacccatt tccaggactg aacctaggtc agagctctaa attggtcctt     2880

ctatttttca acaaatttaa agtaatattt ctttctaata taatattgca tcctttgtgg     2940

gaatgactat aggtaaaatg tagtaagtaa cgcagaacca gggttggctt tatttaaaag     3000

ctagtgacct aaatagaaag cgaacttcaa gagaagttgt aagtacagtg gcaaatgctt     3060

attacttact tcaaactgtt tcccaaaata agtgcattta ttttgacaat aaaacttaag     3120

gctgttcatg agaaggcctt gaaaagttac tctagaggaa aaatgtctaa agaaaaaaaa     3180

aattcaaaaa gtttacatta attattcagt gttgtgagta aataaaaatg tgtgctcttt     3240

actgtttttc atttttaaag aatattatta tggaagcacg atttatttaa ataggtacat     3300

tgagactttt ttttttttaa tgttctgata cattaggatg aagttaaatc ttaaatctta     3360

ttagttgaat tgttgtaagg acagtgatgt ctggtaacaa gatgtgactt tttggtagca     3420

ctgttgtggt tcattctttt caaatctatt tttgtttaaa aacaatacaa gttttagaaa     3480

acaaagcatt aaaaaaaaag cctatcagta ttatgggcaa tatgtaaata aataaatgta     3540

atatttcatc ctttattttt caggtaaaag gtcatgctgt tacaggtgta gtttgtgtgc     3600

ataaataata cttccgaatt aaattattta atatttgact gatttcaata actgtgaaaa     3660

ataaaaaagg tgttgtattg cttgtgagaa cttgaactgt ttactagtta attgaagaaa     3720

aagtgtaaca ctaaggtgaa cttgcttccc ttttcactaa ttttgctaaa ctttgtaatg     3780

cacattctta gcatataact gaacacagtt gaaaaattgt gcctgattat aatgtatgta     3840

taatggtagg tgtttgtgtg tgattcattt ttaaagaaat atttttctca agctcctatt     3900

actatttgtg gttgtattat ttcactaatc attagttaag actgtgctag tcttccctgg     3960

gaaactaaga agagagcttt tttatataca gtatattaga attttcctag tagctgaatt     4020

tctgtattag gtctaaatat tactgtatgt tatataaagc aggtatgtca agtgtatagc     4080

cgtagtctat aattcaggaa tgctttataa ccatcagaag ccattatttg cactacatat     4140

atgataagta tagacagcaa taaaatgtta agatcatttt taagaa                    4186


<210> 239
<211> 2896
<212> DNA
<213> Homo sapiens

<400> 239
aaaaagatgt gatcaagagt gagttgggtt ggaggcaggg actgctctgg attaaatggc       60

caagaaaggc catgctgagg tgtaaactga gccctgaagg aaaagtattc caggcaaagt      120

gcaaaactct gaggcaaaaa cctctttgga atgtatgagg gaggttcagg gaagcaagga      180

ggagaggaaa gaatccaagt cccgaggtac aggagaggac aagaagtaga tcttgcagag      240

ctgctagtaa gcggcatccc acctaacatt ttgagggcca gaagtagcca cagagcccct      300

ctcacgcaag ggagtaatgt ctatatgctt tttttttttt tttgagacgg tctccctttg      360

ttgtccaggc tggagtgcgg tggtgcaatc ttgcctcact gcaaactcca cctcctgtgc      420

tcaagcgatt ctcctgcctc agtctcccat gtagctggga ctacaggtgt gtgctaccac      480

acctgtctaa tttttgtact tttagtagag acagggtttc accatgttgc ccaggctggt      540

ctcaaactcc tgacctcaag tgatccgcct gcctcggcct cccaaagtgc tgagattaca      600

ggtgtcagcc accgcgcccg gcctgatata cacttttaag gctccgggct gtccatgagg      660

atcaagcgtg gaagtaggtc tacagaaaag gctgccgcag ttcacccatg acaggtgatg      720

acagtctgga catagggagg atggagagaa gtcgtgcgcc ctggcagtat ttcaggagcc      780

aactagtgga gccgggacgc gagaaataga ggaaccaaga agccataagg aggaggaaga      840

gcagcgggta ggtcaagatg ccacagccgc aggaggggct gttggggtcg gggttacccc      900

catccctgtg caggcggact tggcgtctga ggacagagtc cagaccacaa ggatctggag      960

ctcaggagag actcgtgggc cacagcccga gaaagcgctg ggaatccaaa tactatggcg     1020

attggcagtc gcgtaggcga ggcgggctag agacccgccc ggatttaggc gcgagccacc     1080

tccaggggcg gggcccaggc cgcactgcgc aggcgcggct aacccgtttc catggctgcg     1140

agaactgacg ctccccaacc gtcccgcaac tgtcctgtcc cagactttgg caccgtcggg     1200

gtccgtcgtc cccgaatgtg acagcatccc caccccggct gctgcccagg atccgccgga     1260

ccccggcctc gatatgggag acctggaact gctgctgccc ggggaagctg aagtgctggt     1320

gcggggtctg cgcagcttcc cgctacgcga gatgggctcc gaagggtgga accagcagca     1380

tgagaacctg gagaagctga acatgcaagc catcctcgat gccacagtca gccagggcga     1440

gcccattcag gagctgctgg tcacccatgg gaaggtccca acactggtgg aggagctgat     1500

cgcagtggag atgtggaagc agaaggtgtt ccctgtgttc tgcagggtgg aggacttcaa     1560

gccccagaac accttcccca tctacatggt ggtgcaccac gaggcctcca tcatcaacct     1620

cttggagaca gtgttcttcc acaaggaggt gtgtgagtca gcagaagaca ctgtcttgga     1680

cttggtagac tattgccacc gcaaactgac cctgctggtg gcccagagtg gctgtggtgg     1740

cccccctgag ggggagggat cccaggacag caaccccatg caggagctgc agaagcaggc     1800

agagctgatg gaatttgaga ttgcactgaa ggccctctca gtactacgct acatcacaga     1860

ctgtgtggac agcctctctc tcagcacctt gagccgtatg cttagcacac acaacctgcc     1920

ctgcctcctg gtggaactgc tggagcatag tccctggagc cggcgggaag gaggcaagct     1980

gcagcagttc gagggcagcc gttggcatac tgtggccccc tcagagcagc aaaagctgag     2040

caagttggac gggcaagtgt ggatcgccct gtacaacctg ctgctaagcc ctgaggctca     2100

ggcgcgctac tgcctcacaa gttttgccaa gggacggcta ctcaagcttc gggccttcct     2160

cacagacaca ctgctggacc agctgcccaa cctggcccac ttgcagagtt tcctggccca     2220

tctgacccta actgaaaccc agcctcctaa gaaggacctg gtgttggaac agatcccaga     2280

aatctgggag cggctggagc gagaaaacag aggcaagtgg caggcaattg ccaagcacca     2340

gctccagcat gtgttcagcc cctcagagca ggacctgcgg ctgcaggcgc gaaggtgggc     2400

tgagacctac aggctggatg tgctagaggc agtggctcca gagcggcccc gctgtgctta     2460

ctgcagtgca gaggcttcta agcgctgctc acgatgccag aatgagtggt attgctgcag     2520

ggagtgccaa gtcaagcact gggaaaagca tggaaagact tgtgtcctgg cagcccaggg     2580

tgacagagcc aaatgagggc tgcagttgct gagggccgac cacccatgcc aagggaatcc     2640

acccagaatg cacccctgaa cctcaagatc acggtccagc ctctgccgga gccccagtct     2700

ccgcagtgga gagcagagcg ggcggtaaag ctgctgaccg atctccctcc tcctcacccc     2760

aagtgaaggc tcgagacttc ctgccccacc cagtgggtag gccaagtgtg ttgcttcagc     2820

aaaccggacc aggagggcca gggccggatg tggggaccct cttcctctag cacagtaaag     2880

ctggcctcca gaaaca                                                     2896


<210> 240
<211> 6087
<212> DNA
<213> Homo sapiens

<400> 240
gttcctaaac gccagctcgg agcaatcccc ttgggctgga gccaaatccc tgctgtgatt       60

ttaaggaaga ccggcaggtc cgggccccca agggtcaacc ccacacacat ccccgcactt      120

tcctgtatgc aggcctgcga gcgtagaggg agtggaattc acagcctccc cacccatccg      180

caggggtctc ctgggaggaa cccaccagcg ataggaacac tgaagctggg ctacggcgtc      240

cgcccgagcc ttttcttaaa ggcgccgacc ccggaagcgg ggcgtccgag ggagcgcgcg      300

acgggccacg cacgtccggg cgtccagttc ggggcagctt ctccggctgg tgggtgggtg      360

gggcagcctt tcaggcaggg tggcaaccaa ctatatctga ggaccagagc cattttgggg      420

caccagagct tgtgacctct ccatctccac ccagctgggt ccaggggcca ctctcagcac      480

tcacctcagc agctgacatc ataaagcaga cttgggaacc tggaagcact ctggagaacc      540

tttccctgag acatggagct ttggggccga atgctgtggg ccctcctgtc tggcccaggg      600

aggaggggaa gtacccgggg ctgggccttc agctcatggc aaccccaacc acctctggct      660

gggttatcca gtgccataga actggtcagc cactggactg gggtctttga gaagaggggt      720

atccctgagg cccgggaatc cagtgagtac atcgtggctc atgtccttgg agccaaaaca      780

tttcagagcc tgaggccggc actttggacc cagcccttga cctctcagca actacagtgt      840

atccgggagc tgagtagccg tcgattgcag aggatgccgg tgcagtacat ccttggagag      900

tgggacttcc aggggctcag cctaaggatg gtgcccccag tgtttattcc tcggccagaa      960

acagaggaac tggttgagtg ggtgctggaa gaggtggccc agaggtccca tgctgtggga     1020

tccccaggca gccccctcat tctggaggtg ggctgcggat caggagccat ctccctcagc     1080

ctgctgagcc agctccccca gagccgagtc attgctgtgg ataagcggga agctgctatc     1140

tctctgaccc atgagaatgc tcagaggctt cggttgcagg acaggatttg gatcatccac     1200

ctcgacatga cctcagaaag gagctggaca cacctgccct ggggccccat ggacctgatt     1260

gtcagcaacc ctccctacgt cttccaccag gacatggagc agctggcccc tgagatccgc     1320

agctatgaag accccgcggc cctggatggt ggggaggagg gcatggacat cattacccac     1380

attctggcct tggcaccccg gctcctgaaa gactctggta gtatcttctt agaagtggac     1440

ccaaggcacc cggagcttgt cagcagctgg cttcagagcc ggcctgacct gtaccttaat     1500

cttgtggctg tgcgcaggga cttctgtggg aggccccggt tcctgcatat ccggaggtct     1560

gggccatagc atggctgccc tgtggatgcc ttgtcagtgc cgccagcctg accagagggg     1620

aggtggatgg cactttccag agcccaggtt cttatggcat ttcccagggt tctgtgattt     1680

ccccatgctc tgcatttcta ggatatttct aggacacctg gattggctcc atcacatcag     1740

agtggctgag ggcagttgct ctgtgttggt gaaattgctg tgggggtatc gggggatatg     1800

gccagtaaag tattgagaga ctaacaaatg gtgacctaat gttttgtcca tgacttgcag     1860

gtcccctgac ccccttactc ccaggtagca ctggggcaag ggtttccttc tgccccagca     1920

gggctggccg tcagtcccct gcttggtagt ggtgtggggg tgcagtgtgg aggaaggcac     1980

gtgagtcctc actcctggcc ttggatacca tgggtcctgg catagagcag ctcactccca     2040

gggattgatt agtcctccac tgccctgggt gcatgcgtac acaattccct ggccaagcct     2100

ggctcgagca caggaagctc atctgcgttt tggctcaagg atgactgcct gctttctgga     2160

ggggagggtc tggaggtctt tgctgcacag ttcctgggtc gcacatccac gttcatttaa     2220

ctgaaggctt gagccagtga ggggtgtttc ctttttatcc ccatagcttt tagctaaaac     2280

atccctcccg agttgacccc ctggggtttc aaataaccca tgtgtccctg gttggggctg     2340

gggagagtga gaagctgaga tactgggcac agggttgtgg cctccacccc agctctggtc     2400

tgtgcagact catggccacc aggaggcctg cagatccagc cttcctgtca acagcgacag     2460

gaaatctcta ggttggtgag tgctggtgat gtgagcctac atcagggtgg gtcctaagaa     2520

acatggcaaa ccaggctgtc tcattccact agactgcccc ctgccaccct ggcacttccc     2580

agggcctggc agtatggtct gatgggcagt atggtccaat aggcagcatc ctctgctgca     2640

gctgggagag ctgagttcca gggctgtgtc ctgcagtggg accttgggca actcctttcc     2700

ctatgagaag ctggctcttc tgagtccagg gccaacgcca actggcaacc tctttactct     2760

tagtcaagtg gaatgtgcat gctggcatct gaatgtccat tcgccaggca tggagagcaa     2820

gagaaggtat gtactgcctg aggtcacatg acagtgacca agtggagaca gtaagttaga     2880

tccctccctt tggggagcct atattgctgg agtcataccc agcctaagtg ttgccctgca     2940

ctatggctgg aggacacatt tggtagaggt cacactgcag ctcccagtgc cccagtgtcc     3000

tgccctgtgc ccagccccag ctgcatggac tctgagctgc ccctggcttc ctttaaggag     3060

gctgctccag aaggaacctg ggtggggagg gcgaaggggg tgcacaacca gggcaaggct     3120

ccccacttcc ttagtccccc atgctcacag acctttgcct gctaaggtcc tcaccagtat     3180

tgccctttct gtctttctcc ttgtgccctt tggctcttgc tgtcttcagc agcatctcag     3240

ggtagctgcc ctgacctcgg agcagtctgt cgccccccta cacctcagcc agtcctggct     3300

tccctgatgg tctctccctc ctggcctcag gcccattcct gaggaagggc cttggcgagc     3360

ttgtggatgt tgcaccagaa gagagtgcag tgttggagag tgacactgtc ggggcagctg     3420

gggccacaag caggagccgg cctcgggcac aactttctgc ccagaaaaat gtgcagcttg     3480

actctgctga ggaaaaggtc caagccaaga ggactggcag gcggggcctc aagcctgcag     3540

ccactggctt gattgggccc tggacgttga gcccagatgt tggagccaca ccagcctgga     3600

tttcaatccc agaatctgcc cctcacgagg atgtgacctt gggcagatga cttcacctca     3660

ctcagccttg gcttctaagg ctgagaaatg ggacttaatg ctttatttta taggatgcat     3720

gtgaggagcc catgggatgt gcctggcttg gcacattgtg gcatttttcc ttgccttcct     3780

cggagggcag acacagggag gaaggaccca gtgccctcag gcgtccatct gatgcatggg     3840

accaacataa ggcaggcagg gatacaaggc agtctggaaa gaagggaagg caggagtttc     3900

agtcttgggc tcttgactcc tcactgttgt ctagagatgg agccagcagg ctggtagcct     3960

ggcagcctac atctcccctc agcctctcct cactatggcc ccagtgcctt gaggcccagg     4020

ccagggcagc cagtggctct agctcaggga aagccaggcc cacctgccct atcccctccc     4080

ttgctcctga ggccaaagcc agagactcga acagcctccc caccaccacc agcatatgtc     4140

aaggagcact tgcaggcaga atgggaggag gacatggagc tgatggagtc caggctgtgc     4200

aagcccctga ggtcttgaga gatgtgccca ctgcccgtgc agcctccttc agccagagcc     4260

cagagcatag acaggagtgt aggagtccct gtttgatgta ctctgggaga gtaattctat     4320

ctcctcttct gatagttggg gaaactgagg ccttgtctca cagttggatg cttttcccag     4380

ttgtcagtgg gtttctccat gggtctcata cagctgcctt attgaaatag gccccgaacc     4440

ccctaaatgc aaaaaatact cttttttgct cctttacccc cacctggacc ctgggctatt     4500

ggctgctccc aatccttgcc ccaaacactt agctggctcc ccatgactta agtgtgttct     4560

cttgtgtcct atggaatcca gttctgaaga ggtgggggag gacaactgtg ggaaaagccc     4620

tgggggcccc tcccaaggcc ccatcagtgc tctgagtagg ctgtcatcag aacaaagggc     4680

tccactgctg acaaggtttg agaactgctg gcttgaggtg agaacccctt taacctctgc     4740

gggacagcat gtctttccct atccaccttc gattcttttc tctttttttt cttcattggc     4800

tccttcttag tggattctct tctctactgc cctgggcttc agcctttgtg cagtactctc     4860

gatgccctga acacacacct tccctttgcc caggcggtgc aaacaatcca cttcttcaag     4920

ctccaacaca aatgctgcct cctttaggat gcctgctctg tgctctccct gcctccccta     4980

gcccatacct ctgctggcac cttctgtacc atgccttcag aaaccttctt atccccctca     5040

tctctggggc cccctgtgga tctggcatac ccaagttcag taaatgtcta tcagtaagct     5100

gatggtacat gcattttcta gaatagagct gggacttccc atgtggccca catctgacct     5160

ggcagcccat gtattccggt cattagggat gggaagccat gaggacctgg ccttctgccc     5220

gacccaggca gccattcaag ttgagcaatg gccacttcga agactcaagt gcacctgatc     5280

cctgcgcaac agccacacca ggagaacagg ctgtccttgg cggcagtagg agcaggcgcc     5340

aggtttcctg gagctcttgg cttcagccag cccccagcca gagtcctggc taggacagtg     5400

acctgatctc ctcctcatga ccttctgccc tggacaagcc ccctgaactg gatttgggac     5460

tgtcaaagca actctacccc tgctctggta ggctgaacag tgacccccca aaatggcagt     5520

gtcttaatca cctaaacctt aacatgtgac tatattacct tcacatagca aaatggactt     5580

tgcagatgtg attaaggatc ttgagatgga aggagtatcc tggatttttc aggtaaactg     5640

agtataatca caagggcctc tgtaaaggag gcaggagtgt cagagtgacg gaagaaaatg     5700

tatgtaacaa tggaagcaga ggtcagagtg atgcaattgc tggaggaaga gccatgagcc     5760

gaggaatgca gacagcctct tctcctctgg ggcctcaaga agaatgcagt cctgccaata     5820

ccttgatttt aagccctgtg aaactgattt cagattgctg acctccagaa cagtaagatc     5880

ataaatttgt gttgttttca catgtgtgaa aacacatgtg tgataatttg ttacagcagc     5940

cacgggaaac gaatatagat tgtggtgccc aaattagagt gctgctgtaa cacacgccta     6000

ctgattgaag tggctttgga attgcaacgt ggaaatgggc agaggctgga agaattttga     6060

gagtcatgat aaattgcctt aaccacc                                         6087


<210> 241
<211> 4660
<212> DNA
<213> Homo sapiens

<400> 241
aagaggcccc agcagccgaa gggaaaccgg cgcgtccccc gcccgcccag gcgtcagctg       60

atgggctgcc tgccgaggag gccgcagcag tcgccgcgcg aacatggcgg ccgaaatcca      120

ctccaggccg cagagcagcc gcccggtgct gctgagcaag atcgaggggc accaggacgc      180

cgtcacggcc gcgctgctca tccccaagga ggacggcgtg atcacggcca gcgaggacag      240

aaccatccgg gtatggctga aaagagacag tggtcaatac tggcccagca tttaccacac      300

aatggcctct ccttgctctg ctatggctta ccatcatgac agcagacgga tatttgtggg      360

ccaggataat ggagctgtaa tggaatttca cgtttctgaa gattttaata aaatgaactt      420

tatcaagacc tacccagctc atcagaaccg ggtgtctgcg attatcttca gcttggccac      480

agagtgggtg atcagtaccg gccacgacaa gtgtgtgagc tggatgtgca cgcggagcgg      540

gaacatgctc gggaggcact tcttcacgtc ctgggcttcg tgtctgcaat atgactttga      600

cactcagtat gctttcgttg gtgattattc tgggcagatc accctgctga agcttgaaca      660

gaacacgtgt tcagtcatca caaccctcaa aggacatgaa ggtagtgtcg cctgcctctg      720

gtgggaccct attcagcggt tactcttctc aggagcatct gacaacagca tcatcatgtg      780

ggacatcgga ggaaggaaag gccggacgct gttacttcag ggccatcatg acaaggtgca      840

gtcgctgtgc taccttcagc tcaccaggca gctcgtctcc tgttcctcgg acggcggaat      900

tgcagtgtgg aacatggatg ttagcagaga agaggctcct cagtggttgg aaagtgattc      960

ttgtcagaaa tgtgagcagc catttttctg gaacataaag cagatgtggg acaccaagac     1020

gctggggcta agacaacatc actgcaggaa atgcgggcag gctgtctgcg ggaagtgcag     1080

cagcaagcgc tcaagttacc cagtcatggg cttcgagttc caagtccggg tttgtgattc     1140

ttgttacgac tccatcaaag atgaagatcg gacttctcta gcgacctttc atgaaggaaa     1200

acataacatt tcccacatgt ccatggacat tgccagggga ctgatggtga cctgtgggac     1260

cgaccgcatt gtaaagatct gggacatgac acctgtggtg ggctgcagtc tggcgactgg     1320

gttttctccg cactgatctg agagctgggc ggcgtccaca cctaagaaca gcagctccac     1380

caaatgaagt ccctctcacg cagctccaca gcgctgtctc gtgaatggac agtagccact     1440

tacaaacaaa tcaacatttt taaaaagaaa atgtaaaggt gtgttttggg gcatttgtgg     1500

aacttaccca tggggactaa tatggaaaag gtctgtccat agtggttccc tgaagactgg     1560

aattacttca gcaaaacttc cccatgaaca gctaatgtgt agtgaaagaa tgagctagca     1620

aatgagtttt agcggggaca aaaaatcaaa caaaaaagtg aatgcttaga accttctcaa     1680

agcagtcaca agtacagaca cttcacttag cctagggggc cttccagggt tcttgtggct     1740

gttgtcagag caggagctgg gggagggaag acttgttctc tctttcttga ggggtggcat     1800

taggaactta cgaaaccaga gacctttccc tatgacttgg cagtatgtga atatcctcta     1860

cacttagtta ttgataaact tcttaaagag atctgttatt ttcaggtagt gccataatct     1920

gcacttagca ttggcttgct tcagttgttt ctcttcccag ccagtatgcc acaggtgaac     1980

tttcggggtt gtcattaagt aagttgtgaa atttctgtaa taacaaaggc agtccgcatt     2040

cttccctttc ccccaaattc ctagggcaaa acttttttat ggtgctgtta acatgggagt     2100

cacacaagcc gcctgacttt ttctcattgc cattagtaat gactgatgga aaacccagcc     2160

accactgtga tgcgaaatga tcagtctgtt gcctgaaaca gcccagtcct cttaactgaa     2220

acagcattct acttcttgtt ccaagatgag cctctgcaat attctggcaa tttaatatac     2280

cccctacaaa agcactccac agcttttaca ctattttgac tttgagttat aactagtatt     2340

attcatgttt tcataaaaag aagttagtga cccagagcta taatcatcca tcaagtcttc     2400

cacaataatt cccaactcat aaattgcttt cctaacaact agcaaaagct attgttcata     2460

atggcatttc taaagctttt gggcactgtg taccaggatg aggaagagaa gaaatgagga     2520

gcctgtcttt taatattcca gtatttgtgt gtttgatttt ttttgacaac agtacatata     2580

tctatttctc tagggatatg gaagtaagtg gagaagggcc taccttttta aaggacaaat     2640

ataaaaatag caacagtatc tttgctaatc ttactaatag atattgatta aaaaaaaaaa     2700

acctcagtac tgcatcactg tgttgggatc ataccaggac aatagggtca ttccatatga     2760

taaaactaaa ggactaaatt tgttttataa tgatgtctta gagggactga aaggtttaag     2820

gaggcgatca aactaaaatg tcttaatggc tgtgtgacac acgtaaggaa aggaaagggg     2880

gtcacgcaca tcatgtactg gaatgatctg cattaaacat agacttgtct tcagaaataa     2940

gactgaaggg ttttgttgtt ccttagagtt ttcgtgttac atcacctaaa gagatttctt     3000

ttaaaaactt tctagactct ttgcaaaatg tatattacta acatagtttg gaagaaaaat     3060

tgagtagtgg taagttttgt tcaagcacaa tgttgaatgt taagcttcct gtattaattt     3120

tagttcagtt aatggttcag cccatacaaa ggtgctatcc tagggatttt atgaattcct     3180

gaaaggaaaa tagaatatga tcaattcctt gccctgtgga agagtgcaga actgtggttt     3240

tgttttcctt tgacttctgt aaaatgtgac cgtttgacat ctgtggtaga ttgaacggaa     3300

tatcacagct gctgagttta ctccatagct ttcaaacctt ttttatttta agaaattctt     3360

gaaaaaccct atgttccatg ggaacataaa gttattatag tgcctcctaa ggggttaata     3420

taaatcaagg aggaagttta tatttaagga agaattggag tgacgtatct tagaaaagga     3480

aaggctgatg tttccatata gcttgctctc caccaggcct atcatttttc tttttagaga     3540

caaacgtgac aggctagtct tgtctctctc atatgctagg tagcaaatgg ggtgatattt     3600

ttatagaagt gggcaaaaat tattttctca attttactga gtaggcacag aagaaaagta     3660

cagataggct gatggttatt gccttatttt gactgcattt ctcttaaatg gatcatttaa     3720

attagttctt caagtaacag tttactggtt gttccattcc tgaatatgca ggctaatttg     3780

tacagatagg gattaaggaa tacagactat tagagaagat ccttatattt acatctagta     3840

tatatgtggt aaggaaatgc cgattcttca ttataaacaa gttttaaaat tgttctttct     3900

tagttcaaat gatagcaata cccctatagc attaggtaga aacaaattat tcattacatc     3960

gtaaatctct ttactatgtc ctagctctgt cctgctacct aaaggatata aagaaatact     4020

attgctctag aatgtattac tttgttctcc catgaaagaa ttcagtttgt tagtacctat     4080

atttttaaac tggtgaaact gacccaaata tgtaataaat accatagtag ctcagaccca     4140

aggagatatt tttctaaaat cagttttcgt taaagtactt ctacttccgt tattggatat     4200

ggtatctcct aaagtgtaaa aaaaatctgt tactatatag tgataaacca tctgctcatc     4260

gtaagtgtaa ggcttaacaa ataagtaata catgctatat ttattcaagt gtctattgct     4320

taattgttaa ttgtgagcag atttattgaa tgcctattct attttctgca gtttacaata     4380

caataactct ttgagtaagt tgaagtttaa ttgtgcaaca aatttgtatt agagtacaat     4440

ttaaagtgtt tttctctata gccttttttg actggggaag caaggggtaa tgttaattag     4500

tacactttgt tcttgtacta gctatgtttc tataagatat ggtgccctgt gtatcccaga     4560

gatgctagaa aactgttctt tgctcctatt tgtgggttct gtttttgtgg gttttttttt     4620

ttgagaaaat gtacacaata aaacattcct tgcttgttac                           4660


<210> 242
<211> 2185
<212> DNA
<213> Homo sapiens

<400> 242
cgcgcggtga ccgttggcgc cgaggggagg aggcagccgc cgccgccgcc gccgccgccg       60

ccgccgccgc cgccgccgtt gcgcagatcc gggccgcggc tgtggggagg gcgacggagc      120

gggtgacctt ccggaggcgg gagcgagcga ggaggcccgg gagcgccgag cgtcgccgcc      180

gccgccgcca tgaacaactc gggcgccgac gagatcggga agctcttcgt gggcggtctt      240

gactggagca cgacccaaga gactctgcgc agctactttt cccaatatgg agaagtcgta      300

gattgtgtta tcatgaaaga taaaaccacc aaccagtctc gaggctttgg gtttgtcaaa      360

tttaaagacc caaactgtgt ggggacggtg ctggccagca gaccgcacac gctagatggc      420

cgaaacatcg accccaagcc atgcacaccc cgggggatgc agccggagag aacacggccg      480

aaggaaggat ggcagaaagg acccaggagc gataacagta aatcaaataa gatatttgtc      540

ggtggaattc ctcacaattg tggtgagaca gagctcaggg aatacttcaa gaagttcgga      600

gtggtcacgg aggtagtcat gatctatgac gccgagaagc agaggccccg aggttttgga      660

tttattactt tcgaggacga acaatcagtg gaccaggctg tcaacatgca ttttcacgac      720

atcatgggca aaaaagtgga agttaaacga gctgagcctc gggacagcaa gagccaagcg      780

ccgggacagc caggtgccag ccagtggggg agccgggttg tgcccaacgc tgccaatggc      840

tgggcaggcc agcccccgcc cacgtggcag caaggatatg gcccgcaagg aatgtgggtg      900

ccggcaggac aggcgattgg tggctatgga ccgccccctg caggaagagg agcccccccg      960

ccacccccac cgttcacctc ctacatcgtg tccacccctc ctggaggctt tccccctccc     1020

cagggcttcc ctcagggcta cggtgccccg ccacagttca gttttggcta cgggcctcca     1080

cctccaccgc cagatcagtt tgcccctccg ggggttcctc ctccaccagc cactcccggg     1140

gcagcacctc tggctttccc accgcctccg tctcaggctg ccccggacat gagcaagccc     1200

ccgacagctc agccagactt cccctatggt cagtatgcag gttacgggca ggacttgagt     1260

ggcttcggac agggcttctc agaccccagc cagcagcctc cttcctacgg gggtccctcc     1320

gtgccagggt cggggggccc ccccgccggc ggcagcggct ttggacgagg gcagaaccac     1380

aacgtgcaag ggttccaccc ctaccgacgc tagcccgcgg cgccgcgacg tctgcacggc     1440

ccagacccag gattccaaac ttgtgaactc gtgacaatca caaacttggc ggcaaagtgg     1500

cgactcaacc ttgggggggg gggcgggggg agggcgcgag gcttttggag cggctgtggg     1560

tgtcgtctgg actgaggttt ttaaatattt ctttctctaa cccatcagca caataaaaaa     1620

aagtcactgg ttcaacaaca gggtttaaaa aaaatgtctt cagctttaat tcaaaacttc     1680

aggtttcttt ttcttccttt tttttggaaa ttattttcct gagccttttg ttttacggta     1740

tattgtaaac ttttatgtta aagaaaaaat atacatttac aaattgtgag atttttaaga     1800

gaaattttct acgatgtata ctggcttatt ttttaattta aaacggggtt tccgtcggca     1860

ctggtggagg gggtgcgctg ttagtcccct cgctcctggc tttgggggtt gggacttggt     1920

ggtccagaaa ctctgggagc ttctagaaga aatctactga gtgtatttct gttttttgtt     1980

taattccttg cttttgtcga ctgacctgct tggtagtgtc tgaggtgaac tgtgggggtt     2040

gcgcacagcc agccgcgtgg atcccacgca gcgctgaacc gaaccgagta ggaagccttt     2100

ctccccaggc acgtggcttc agggcgtttc ccattgacca gtttgaccct ggtttgaata     2160

aagagaagtg cgtttggatt agaaa                                           2185


<210> 243
<211> 492
<212> DNA
<213> Homo sapiens

<400> 243
atataaggct aggggcgggc gccgctcttt tgtttcttgc tgcagcaacg cgagtgggag       60

caccaggatc tcgggctcgg aacgagactg cacggattgt tttaagaaaa tggcagacaa      120

accagacatg ggggaaatcg ccagcttcga taaggccaag ctgaagaaaa cggagacgca      180

ggagaagaac accctgccga ccaaagagac cattgagcag gagaagcgga gtgaaatttc      240

ctaagatcct ggaggatttc ctacccccgt cctcttcgag accccagtcg tgatgtggag      300

gaagagccac ctgcaagatg gacacgagcc acaagctgca ctgtgaacct gggcactccg      360

cgccgatgcc accggcctgt gggtctctga agggaccccc ccccaatcgg actgccaaat      420

tctccggttt gccccgggat attatagaaa attatttgta tgaataatga aaataaaaca      480

cacctcgtgg ca                                                          492


<210> 244
<211> 2887
<212> DNA
<213> Homo sapiens

<400> 244
atcatacacg tctaagggca gagtgaactt ccatcctgaa ggctccgcgc ttagttttcg       60

cagattaata gctcaccaag aatttatcat cttttctttc cactaactcg aaaccaatct      120

aaattctttc caaacatctt ctcaacgtag tctcctttga tgaaatttac tgtttcggat      180

tctagacttg gctcttacca acttaacttt cggttaatag cttaatacct ctgattcagg      240

tttttgcatt tgtcaactac cattgaatga taatttcaat gagttcgttc ttatgaggat      300

caaatgaaat aacatctgtg aaaacctctt acaaagttta agcaaatagt gctaagcaat      360

caccaagcgt taactactaa ttttcagtgt taggcattag aactgtcatg gcgccttcaa      420

gaagaggtag gaggccctct ctgcgtccag cagaaccatc tggggcacct ggaccgggcg      480

gtggggtgga cagagagacg agccccagct gggaccgaaa acatcgaccc ctccgagagg      540

tctcggccgg accggcgcaa ggggaggaga gcgggtggaa gcccacccca gcgaacgccc      600

gagggccggg ccccgcccac ccagaacgtc acccaatgga aacctgccgg cggtgcggca      660

ccgcccatcg ttggtccggg cgccgcgagg gcggggcccg cagttcggtt gcgctgcgga      720

gcgcagctgt gagggagtcg ctgtgatccg gggccccgga acccgagctg gagctgaagc      780

gcaggctgcg gggcgcggag tcgggagtgc aggcctgagt gttccttcca gcatgtcgga      840

gggggagtcc cagacagtac ttagcagtgg ctcagaccca aaggtagaat cctcatcttc      900

agctcctggc ctgacatcag tgtcacctcc tgtgacctcc acaacctcag ctgcttcccc      960

agaggaagaa gaagaaagtg aagatgagtc tgagattttg gaagagtcgc cctgtgggcg     1020

ctggcagaag aggcgagaag aggtgaatca acggaatgta ccaggtattg acagtgcata     1080

cctggccatg gatacagagg aaggtgtaga ggttgtgtgg aatgaggtac agttctctga     1140

acgcaagaac tacaagctgc aggaggaaaa ggttcgtgct gtgtttgata atctgattca     1200

attggagcat cttaacattg ttaagtttca caaatattgg gctgacatta aagagaacaa     1260

ggccagggtc atttttatca cagaatacat gtcatctggg agtctgaagc aatttctgaa     1320

gaagaccaaa aagaaccaca agacgatgaa tgaaaaggca tggaagcgtt ggtgcacaca     1380

aatcctctct gccctaagct acctgcactc ctgtgacccc cccatcatcc atgggaacct     1440

gacctgtgac accatcttca tccagcacaa cggactcatc aagattggct ctgtggctcc     1500

tgacactatc aacaatcatg tgaagacttg tcgagaagag cagaagaatc tacacttctt     1560

tgcaccagag tatggagaag tcactaatgt gacaacagca gtggacatct actcctttgg     1620

catgtgtgca ctggagatgg cagtgctgga gattcagggc aatggagagt cctcatatgt     1680

gccacaggaa gccatcagca gtgccatcca gcttctagaa gacccattac agagggagtt     1740

cattcaaaag tgcctgcagt ctgagcctgc tcgcagacca acagccagag aacttctgtt     1800

ccacccagca ttgtttgaag tgccctcgct caaactcctt gcggcccact gcattgtggg     1860

acaccaacac atgatcccag agaacgctct agaggagatc accaaaaaca tggatactag     1920

tgccgtactg gctgaaatcc ctgcaggacc aggaagagaa ccagttcaga ctttgtactc     1980

tcagtcacca gctctggaat tagataaatt ccttgaagat gtcaggaatg ggatctatcc     2040

tctgacagcc tttgggctgc ctcggcccca gcagccacag caggaggagg tgacatcacc     2100

tgtcgtgccc ccctctgtca agactccgac acctgaacca gctgaggtgg agactcgcaa     2160

ggtggtgctg atgcagtgca acattgagtc ggtggaggag ggagtcaaac accacctgac     2220

acttctgctg aagttggagg acaaactgaa ccggcacctg agctgtgacc tgatgccaaa     2280

tgagaatatc cccgagttgg cggctgagct ggtgcagctg ggcttcatta gtgaggctga     2340

ccagagccgg ttgacttctc tgctagaaga gaccttgaac aagttcaatt ttgccaggaa     2400

cagtaccctc aactcagccg ctgtcaccgt ctcctcttag agctcactcg ggccaggccc     2460

tgatctgcgc tgtggctgtc cctggacgtg ctgcagccct cctgtccctt ccccccagtc     2520

agtattaccc tgtgaagccc cttccctcct ttattattca ggagggctgg gggggctccc     2580

tggttctgag catcatcctt tcccctcccc tctcttcctc ccctctgcac tttgtttact     2640

tgttttgcac agacgtgggc ctgggccttc tcagcagccg ccttctagtt gggggctagt     2700

cgctgatctg ccggctcccg cccagcctgt gtggaaagga ggcccacggg cactagggga     2760

gccgaattct acaatcccgc tggggcggcc ggggcgggag agaaaggtgg tgctgcagtg     2820

gtggccctgg ggggccattc gattcgcctc agttgctgct gtaataaaag tctacttttt     2880

gctaaaa                                                               2887


<210> 245
<211> 3785
<212> DNA
<213> Homo sapiens

<400> 245
gtcgatttca cgcaggttct atagaatttg ccaagactgc tggcctgttt tctaccctga       60

ttccttaggt ggcttctggg acagaattac ggttctctaa gtatttgctt gcaggatttc      120

tataattggc ctgatgaatc ctttgatgaa atggacagta cactagctgt tcaacagtat      180

attcaacaga acataagagc agattgctcc aatattgaca aaattcttga accacctgaa      240

ggccaagatg aaggtgtgtg gaagtatgaa catttaaggc agttctgcct tgagctaaat      300

ggacttgctg tcaaacttca gagtgaatgc catccagata cttgcactca aatgacagca      360

actgaacaat ggatttttct ttgtgcagct cataaaactc caaaagagtg tcctgctata      420

gactatacta gacacacact tgatggtgct gcatgtcttc tgaatagcaa taaatatttt      480

cccagcaggg ttagcataaa ggaatcatct gtagcgaaac taggatcagt atgccgtagg      540

atttacagaa tattttcaca tgcttatttt catcatcggc agatatttga tgaatatgaa      600

aatgaaacat ttttgtgtca tcggtttact aagtttgtga tgaaatacaa tttgatgtcc      660

aaggataacc tgattgtacc aattttagaa gaggaagtac agaattcagt ttctggggaa      720

agtgaagcat gaagggaatc ataggaaaaa tgtactgatc atataattaa cattatgtac      780

tgtatatatc attttagaca catcaatcat gtatccatat tatagcttct ttgtttagta      840

taggtttttg tatgctgggt ttgcctttta aaatgggaaa tactttttaa gttattcata      900

agctgtatat tcaccagtgt ggcactcatg gtttttaaat aagattagta ttatctgttt      960

ataatgcctg ttaataaaag aatttacagt ttggtaaaat tgctgctaaa caatcattgg     1020

atcacaatcc tcatcagaca aacccatctg taaaaaaaat gagggagagc ttgaggtttc     1080

acacaagcca tttactaaag aggtagaaat gttttctatt ggttttacct tgagtttaga     1140

tatcctaaaa aattctgtag tacgtagttt tgtcttacct gttaactttc cccaattgag     1200

ataaaagtgt tttaaaattc tgtttatagt ttttgatatg catatataat tatgtgtata     1260

tctaaataca aatgcaaatg aagcattagt aatacttaaa taattttact gtgctacata     1320

aagtataaca tacttggaaa ggatttaccg ttctgcaaca acggactggt acatacagga     1380

tgatcacaat ggtaaggcac ataaattatt ttcccactgg aaacctgccc tgtccacccc     1440

ttctcatttc ccttaacctt atcttcaaac tactttagct gagaagcttt tcaccagact     1500

gagttagtgg tggcttatac ctatttatat ttgtattaat tgcttacaga ttatacctca     1560

tattagcaat tacattacac tacaagaaaa tgtatttgca taggctcttg cttatctttg     1620

ttttgcaaaa ttgttctact tagaaaacag tccttaaaat agtttgactc ttcctgttag     1680

taatatatta atctttcatt taaccagcta ggcagcatta aatagaattg aagaaatacc     1740

atagtattta ttttacaccc cctctcccac gaagtttatg tttggattac atgcacgtgt     1800

gagattattt gcaataattc ataggttcca agggtgttga tgaatagtca tacatttttt     1860

tggactttgt tataattcat tgtggtaaga atgattgaaa tgcagattta acaatcttat     1920

aatctattga atgccatttt tgataaagca ctggaggtct tattgccaaa ctgattgtaa     1980

tgaggcagta agggtgaaaa cattgtacat gttgtgaaga aagtatttaa atccaacttt     2040

tgaacagatt taacaaacat gaggaacttt tttatttaga aggataattt tgaagatgaa     2100

aatgtattca tcttaattgt tttttcaaat ttaagggaat aatttatacc atcttttcag     2160

acaagaatgt acagcaaaaa taaggggaac agtagtatac tgagagtgtg tgtatgtata     2220

gtgtatgcct ttccaagctt gccagtcttt ttggctttga acactgccca tcagctacag     2280

tcattactgt tccccaaccc acaactatct tttaagaagt cttagttcac agtgaaagga     2340

atgatgactt tgaaattatg gatttatatt aatggcacta taaaccaatg gtaatggtaa     2400

tttttaaact tgctaaatat tgagaaacta aactactaag ttaataaatt atatatagca     2460

gtgtagctgt tctctctaga tggtgtctca caatggattt ctgttgcttg actattttct     2520

tagtgaatat ttatactaag gtagtgactg agatttggtg atctggctga gtattttgaa     2580

acacattttg aataatatgg cttagtgtta acggggactt aaatatgatt tttttttctt     2640

actcatttca ccttccctgt actgtatgtt tggaattgat cataaaacat ctccaaaaga     2700

aaataatcag tttgtagtct tgcttttgta ttcatgttga taatcttact aattgtgaag     2760

ttgattcact actatactag gtaagaccta agtgaaacag ttcctgtttt tccttaatac     2820

tgttttcaga attttgaaaa tgtacttata tatacataaa tactactaaa aaattaatga     2880

gcctggcaaa ccattgattt ataaaagtaa gtgttctaag aggggaacaa gacagttctg     2940

tgtgataagg aagttaggct ccactttttg tttgaattac cctatgtata tccgaaggta     3000

aacttaggct tttctttcca aaagatcgta tagtcaattc attctttttc tcctatcaca     3060

tctgggaaag tagctaactt ttaactattt atgttcccat aagtaaccct tcttttgtgt     3120

gtatacattt ccttttctct gacttgagat gtcaaatttg gatttctaga acagtttctc     3180

agttaaattc ttgatgactt aacaactttt actatcagaa tacaattaga aatccttggt     3240

caggcacagg ggctcacgcc tgtaatccca gcactttggg aagccaaggc agacagatca     3300

cctgaggtca ggagttcgag accagcctga ccaacatgga gaaaccctgt ctctactaaa     3360

aatacaaaaa ttagccgggc gtggtgctac tcgtgaggct gaggcaggag aatcgcttga     3420

acccgggagg tggaggttgc ggtgagctga gatcgtgcca ttgcactcca gcctgggtaa     3480

cgagcaaaac tccgtctcaa aaactccgtc tcaaaaaaaa aaaatccttg attacattgt     3540

tagtaaggac tgtgttacga ttataaacac atttattggt tgatgtcaaa ttcactgtaa     3600

tagtagaact aagtttttta tgtgagtact ttgccctact gtctatatga tgacatcttt     3660

tttgagcagc taaattttaa attgtatata ctttattttg tgaatccttg ttgaatgtgc     3720

taaaggtttc tttgtgtagt tcttccatgc tatgcgaata ttttagtaaa agtagttgat     3780

tttta                                                                 3785


<210> 246
<211> 5900
<212> DNA
<213> Homo sapiens

<400> 246
aaagttcatc cccccagaat gaaaatgagg acatttgaga aggtgattta aggtgtggac       60

atttgagaag gtgtcctatc aaattagtaa accaaaggaa aagtactgaa tagattaatc      120

caaaacactt actgtttttt aaacgaagag gatttcacct tgacagaaaa acaactttta      180

ttcaatatgt atttcctgaa attaaagaga caagtacaga ctgaaaggaa aatagattcg      240

taaataagct acgtcaactc tatcctgctg aggatagctc agtgatgtta aatcctttac      300

aaatccctgg ttgtcttcct acagacaaga ctgctttttg atgggactga tattaagaga      360

aataggacct ttggggcatt caactccttg ataaaactta aaagtatcgg catgagtggc      420

ttaacagagg aaataaagaa gttttcaact aaatccaaaa gtgcggtcat tttctttact      480

gctgttattt taaaaacctc ttcataacca ttgaaaaaga atcgacaact attttaaaag      540

attaaagaaa ggcagatgtc tgcaaataat tcccctccat cagcccagaa gtctgtatta      600

cccacagcta ttcctgctgt gcttccagct gcttctccgt gttcaagtcc taagacggga      660

ctctctgccc gactctctaa tggaagcttc agtgcaccat cactcaccaa ctccagaggc      720

tcagtgcata cagtttcatt tctactgcaa attggcctca cacgggagag tgttaccatt      780

gaagcccagg aactgtcttt atctgctgtc aaggatcttg tgtgctccat agtttatcaa      840

aagtttccag agtgtggatt ctttggcatg tatgacaaaa ttcttctctt tcgccatgac      900

atgaactcag aaaacatttt gcagctgatt acctcagcag atgaaataca tgaaggagac      960

ctagtggaag tggttctttc agctttagcc acagtagaag acttccagat tcgtccacat     1020

actctctatg tacattctta caaagctcct actttctgtg attactgtgg tgagatgctc     1080

tggggattgg tacgtcaagg actgaaatgt gaaggctgtg gattaaatta ccataaacga     1140

tgtgccttca agattccaaa taactgtagt ggagtaagaa agagacgtct gtcaaatgta     1200

tctttaccag gacccggcct ctcagttcca agacccctac agcctgaata tgtagccctt     1260

cccagtgaag agtcacatgt ccaccaggaa ccaagtaaga gaattccttc ttggagtggt     1320

cgcccaatct ggatggaaaa gatggtaatg tgcagagtga aagttccaca cacatttgct     1380

gttcactctt acacccgtcc cacgatatgt cagtactgca agcggttact gaaaggcctc     1440

tttcgccaag gaatgcagtg taaagattgc aaattcaact gccataaacg ctgtgcatca     1500

aaagtaccaa gagactgcct tggagaggtt actttcaatg gagaaccttc cagtctggga     1560

acagatacag atataccaat ggatattgac aataatgaca taaatagtga tagtagtcgg     1620

ggtttggatg acacagaaga gccatcaccc ccagaagata agatgttctt cttggatcca     1680

tctgatctcg atgtggaaag agatgaagaa gccgttaaaa caatcagtcc atcaacaagc     1740

aataatattc cgctaatgag ggttgtacaa tccatcaagc acacaaagag gaagagcagc     1800

acaatggtga aggaagggtg gatggtccat tacaccagca gggataacct gagaaagagg     1860

cattattgga gacttgacag caaatgtcta acattatttc agaatgaatc tggatcaaag     1920

tattataagg aaattccact ttcagaaatt ctccgcatat cttcaccacg agatttcaca     1980

aacatttcac aaggcagcaa tccacactgt tttgaaatca ttactgatac tatggtatac     2040

ttcgttggtg agaacaatgg ggacagctct cataatcctg ttcttgctgc cactggagtt     2100

ggacttgatg tagcacagag ctgggaaaaa gcaattcgcc aagccctcat gcctgttact     2160

cctcaagcaa gtgtttgcac ttctccaggg caagggaaag atcacaaaga tttgtctaca     2220

agtatctctg tatctaattg tcagattcag gagaatgtgg atatcagtac tgtttaccag     2280

atctttgcag atgaggtgct tggttcaggc cagtttggca tcgtttatgg aggaaaacat     2340

agaaagactg ggagggatgt ggctattaaa gtaattgata agatgagatt ccccacaaaa     2400

caagaaagtc aactccgtaa tgaagtggct attttacaga atttgcacca tcctgggatt     2460

gtaaacctgg aatgtatgtt tgaaacccca gaacgagtct ttgtagtaat ggaaaagctg     2520

catggagata tgttggaaat gattctatcc agtgagaaaa gtcggcttcc agaacgaatt     2580

actaaattca tggtcacaca gatacttgtt gctttgagga atctgcattt taagaatatt     2640

gtgcactgtg atttaaagcc agaaaatgtg ctgcttgcat cagcagagcc atttcctcag     2700

gtgaagctgt gtgactttgg atttgcacgc atcattggtg aaaagtcatt caggagatct     2760

gtggtaggaa ctccagcata cttagcccct gaagttctcc ggagcaaagg ttacaaccgt     2820

tccctagata tgtggtcagt gggagttatc atctatgtga gcctcagtgg cacatttcct     2880

tttaatgagg atgaagatat aaatgaccaa atccaaaatg ctgcatttat gtacccacca     2940

aatccatgga gagaaatttc tggtgaagca attgatctga taaacaatct gcttcaagtg     3000

aagatgagaa aacgttacag tgttgacaaa tctcttagtc atccctggct acaggactat     3060

cagacttggc ttgaccttag agaatttgaa actcgcattg gagaacgtta cattacacat     3120

gaaagtgatg atgctcgctg ggaaatacat gcatacacac ataaccttgt atacccaaag     3180

cacttcatta tggctcctaa tccagatgat atggaagaag atccttaatc actgagctaa     3240

cctaaataag gaaggatttc attttatgga ctgatatttt gctgtgtaac ttgttctttg     3300

tagattgtca tctgcagtgc tgcaaagata tgaagaaata tgataacgaa taagtgacac     3360

cagtactgta gttcataatg agtaggtaca ggcgggaaac tgaataataa gaagtcataa     3420

tggaatcaag gtgaagcttt ttataaactt ttttagccta agcaataact ggttttgtat     3480

tttttcttaa tccttcactt taatacaata ggctcactta atttgtcttc ccatttctct     3540

ttatatatat atatataaat ataaatatat gtttgtttgt ttttttaatg aaaaacaagt     3600

caagctagca tccagttact atatagcttg gctaaattat acaagactta caagattgat     3660

tactcgacag gcttgtattt aagaggtaac tgtgaggtta ccattatgtg atgttactat     3720

aaggactttt aacattggtt taacaaacca tagaggcatt gaagggtttt tcttagatgc     3780

ctagaaaaag cgcactgggc tgttttacct ttctttttta ggtcaatcaa gactccaaaa     3840

tagtgattcc taaccttttt ggagttgctc tgctactctg aatatgttct atacagcata     3900

aggattgtca ccttctgtgt gttgcaacag cttctaagat aattagggac aaatgatgtt     3960

acaaaaggaa gagtactgct ggtctaagtg ctgagttgta tgtctttgca tagctccact     4020

ctgctgctaa atatgcatgt tctgactgac accatcttga tgccagtact ggattccagc     4080

attcagcagg tgcagatctc ggctttacac aatttatctt tacctagggt tcagtcagta     4140

atttctgctt tttagcaggg ccagtgcagg gtcagttaat gctacagtta ctgtatagca     4200

aacagtatcc ttttttctcc ttcccctagc ctattgggct ttgcagatat ctggagtgtt     4260

ttaaagtcaa ttattttaag cagtttgagg ggatgtgtag gagtggagca tgaaacagtt     4320

tataaggctg gggctgtatt atcagcacag caaattaaag aatgaaagaa gtacttcttt     4380

ttacatttca gctccagcag ccagctattt aaaaaatatt tttaaatatc ttccccaaag     4440

tttaagatgt gggaccatct acttgtaaga aacagtggct tatttcttca tttctcagta     4500

atcattgtaa accttttttt ttttcttctc cactctaaca aaagtaaaag aacaaaactt     4560

ttgctgaggt cttggactcc actacttgtt agttatgttg gcctggacag atggcaggtc     4620

tgtcggcagt tcctcagtct gtaaaatgaa gattatcatt cttgcctctc cctttgtcac     4680

agtgttgtcg tgaagatcag atatgtatga atgcagtcaa ataaactaaa aactaggaaa     4740

gtgttaacta tcgttgccca ccgaatttga ggtagcaaaa aaaaaaaaga atgttctggt     4800

acatgaacag actgagaagg cctttcgaca tccctgaagc tagtctcctg tctagactaa     4860

aaatatcctt gaaagaatag tagcaaacag tatgcagtac tcctgtgttc taagttcttt     4920

tatgttttag tttaccctca cagcagccat agtgttaagt cattatgagc ttcatcttaa     4980

agataagaaa actgaggcaa ggggagatta acttactgcc aaatttcaaa cagttagtag     5040

tatttgagac cagtagtatg gctctaatct tacccttagc cctcccaacc attatgctgt     5100

actatctacc cataaatacc tccaggaaac attcccctct tggtaatttg tccttctata     5160

gaagcttcaa agattaaatc aaattaattt tcaaaaaaaa ttttttttta gaaatgttat     5220

tttccctgtg atagaggatg acttcccagt ttcaccaaag tctgtttata tcaacacaca     5280

caaaatggaa taattctgag tcactaggca atcaatctac tgtggtttta ctatgtaagg     5340

tgaaaattaa ctggaacgat gtttgtttgc tatacttaca tagtcaaact ttacaagcca     5400

tgaaattaat tgcactcttt gtatttgttg ttaaatgcct aagaagtttt ctaaaaattt     5460

tgtaaaggca ctgtcagaga atctggagtt gaatgattat tccagatact gtataacctg     5520

cataactttt tgtctttaag tcgtgtttgt aaaagaagta attgctagaa acatttgata     5580

atgtacaaag tagtctataa tgactgttca gtacattttt aatatttttt tggttatatc     5640

caactttttg taaatatact ggaagcttga taataaaatg tatttcctat caccatactt     5700

ttccatgtga aaacctgagc ctatttctag tataagtatc caaagaaaag tttgacctgg     5760

ttgtgttatt ttaccagacc ttggtaaaag aactattttg gaaacagtat ttgtaaatgg     5820

aactaatgct atatttaaaa acactgattt ttttttaacc tgccaaaaat aaaaaaaagc     5880

tcattttata attttctact                                                 5900


<210> 247
<211> 1107
<212> DNA
<213> Homo sapiens

<400> 247
atggaacctg ggcagccccg ggagccccag gagccccgcg agcccgggcc aggagcggag       60

accgctgcgg ccccggtctg ggaggaagcc aagattttct acgacaacct cgcgcccaag      120

aagaaaccca aatcgcccaa gcctcagaat gcagtcacca tcgctgtgtc ctcccgagcc      180

ttgtttcgca tggacgagga gcagcagatc tacacggagc agggcgtgga ggagtacgtg      240

cgctaccagc tggaacatga gaacgaaccc ttcagtcccg ggccagcctt cccttttgtg      300

aaggctctgg aggccgtgaa caggcggctg cgggagctgt accctgatag tgaggacgtc      360

ttcgacatcg tcctcatgac taacaaccat gctcaagtgg gtgtccgcct catcaacagt      420

atcaaccact atgacctgtt catcgagagg ttctgcatga caggtgggaa cagcccgatc      480

tgctacctca aggcctatca caccaacctc tacttgtcag ccgatgcgga aaaagtgcga      540

gaagccattg atgaggggat cgcagctgcc accatcttca gccccagcag ggatgtggtt      600

gtgtcccaga gtcagctgcg cgtggccttc gatggggacg ccgtgctctt ctcggacgag      660

tcggagcgca tcgtcaaggc ccacgggctg gaccgattct tcgagcatga gaaggcccac      720

gagaacaaac ctctggctca gggcccctta aagggctttc tggaggcact gggtaggttg      780

cagaagaagt tctactccaa aggcctgcgg ctggagtgcc caattcgtac ctacttggtg      840

acagcacgca gtgcagccag ttccggggcc cgggctctca agaccctgcg cagctggggc      900

ctggagacag atgaagcctt gttccttgct ggagcgccca agggccctct ccttgagaag      960

atccgcccac acatcttctt tgatgaccag atgttccatg tggctggggc tcaggagatg     1020

ggcactgtgg ccgcccatgt gccttatggt gtggcacaga caccccggcg gactgcacct     1080

gcaaagcagg ccccatctgc acagtag                                         1107


<210> 248
<211> 1362
<212> DNA
<213> Homo sapiens

<400> 248
ccaacgcgca ggcgccgctg ctatgctgag tgccgcgtct cgcgtagtct cccgcgccgc       60

cgtccactgc gcgcttcgct ctccgccgcc cgaggcccgc gcgctcgcca tgtcccggcc      120

accgccaccg cgggtcgcct cggtgctggg caccatggag atggggcgcc gcatggacgc      180

gcccgccagc gccgcggccg tgcgcgcctt tctggagcgc ggccacaccg aactggacac      240

ggccttcatg tacagcgacg gccagtccga gaccatcctg ggcggcctgg ggctcgggct      300

gggcggtggc gactgcagag tgaaaattgc caccaaggcc aacccttggg atggaaaatc      360

actaaagcct gacagtgtcc ggtcccagct ggagacgtca ttgaagaggc tgcagtgtcc      420

ccaagtggac ctcttctacc tacacgcacc tgaccacggc accccggtgg aagagacgct      480

gcatgcctgc cagcggctgc accaggaggg caagttcgtg gagcttggcc tctccaacta      540

tgctagctgg gaagtggccg agatctgtac cctctgcaag agcaatggct ggatcctgcc      600

cactgtgtac cagggcatgt acaacgccac cacccggcag gtggaaacgg agctcttccc      660

ctgcctcagg cactttggac tgaggttcta tgcctacaac cctctggctg ggggcctgct      720

gactggcaag tacaagtatg aggacaagga cgggaaacag cctgtgggcc gcttctttgg      780

gaatagctgg gctgagacct acaggaatcg cttctggaag gagcaccact tcgaggccat      840

tgcgttggtg gagaaggccc tgcaggccgc atatggcgcc agcgccccca gtgtgacctc      900

ggctgccctc cggtggatgt accaccactc acagctgcag ggtgcccacg gggacgcggt      960

catcctgggc atgtccagcc tggagcagct ggagcagaac ttggcagcaa cagaggaagg     1020

gcccctggag ccggctgtcg tggatgcctt taatcaagcc tggcatttgg ttgctcacga     1080

atgtcccaac tacttccgct aggcccatca tggctcaggc tgcccaaggc ttttctgtca     1140

cctcttttgt tctctcacac tgaccagtct tggccttaag ctgacttaga agggtttttc     1200

tgaattgtct agatccatgc attatttttc tagcttcctg ccttgctccc tattcacttt     1260

acactgtgaa aggtgggggg tgagtcccac ttgagcgctt cctgttgaat aaagcaggca     1320

cttgacctgg ctgtagccta ggtcttgagt gaaccccaaa aa                        1362


<210> 249
<211> 1295
<212> DNA
<213> Homo sapiens

<400> 249
atttattgtc gcggggaagc tgcggccgcc tcgcacccgg aacaacaaag caaggaagac       60

ggagtccgag cctcgggggc tcctagcaac gggccggggc gggagttcca tggagactgg      120

ggagcgcgcc cgtctcatcc tcatccttgt cctccagctt ctccttcgca tccgacgcaa      180

ccggcagcag cgctgccgcc gcgtcctcag ccaccgctcc ctcttcccac ggatgtgatc      240

ttcgtggtgg aaagctaaat tttaaaacca ccccaatgga tgcagacagt gatgttgcat      300

tggacattct aattacaaat gtagtctgtg tttttagaac aagatgtcat ttaaacttaa      360

ggaagattgc tttggaagga gcaaatgtaa tttataaacg tgatgttgga aaagtattaa      420

tgaagcttag aaaacctaga attacagcta caatttggtc ctcaggaaaa attatttgca      480

ctggagcaac aagtgaagaa gaagctaaat ttggtgccag acgcttagcc cgtagtctgc      540

agaaactagg ttttcaggta atatttacag attttaaggt tgttaacgtt ctggcagtgt      600

gtaacatgcc atttgaaatc cgtttgccag aattcacaaa gaacaataga cctcatgcca      660

gttacgaacc tgaacttcat cctgctgtgt gctatcggat aaaatctcta agagctacat      720

tacagatttt ttcaacagga agtatcacag taacagggcc caatgtaaag gctgttgcta      780

ctgctgtgga acagatttac ccatttgtgt ttgaaagcag gaaagaaatt ttataattca      840

ccacttaatt ggttagaatc tctaactgag caccttttaa acctgctgca cattggactc      900

aaaaggaaaa ctggaccaac aataattgag gaaatagact cttttattca ttcacggcta      960

cagtgtaagc tccagtccct ttggatttta ttccaaacct tgctgtaata taaaaggaag     1020

tttacaagac atgatattgc tgcttttaca aaaggacatt ctatttattt tcgcagtaat     1080

tctcatgtcc ccataagcag agctgtcaca gtgtgcacta ccttagattg ttttattgtc     1140

gtcattgtta tttttttcca ttttgagcta atgtgtttta tttgtgaata gtcttttaca     1200

tttttgtatg ctgaatatgg gcaccaaaga acctgtaaaa gttatctttt tcaattgaat     1260

gtgcacaaat aaaagtttgg aaaagatctc tcttc                                1295


<210> 250
<211> 2394
<212> DNA
<213> Homo sapiens

<400> 250
gatctctctt gcgccattcc aaacatggcg gctccactag ggggtatgtt ttctgggcag       60

ccacccggtc cccctcaggc cccgccgggc cttccgggcc aagcttcgct tcttcaggca      120

gctccaggcg ctcctagacc ttccagcagt actttggtgg acgagttgga gtcatctttc      180

gaggcttgct ttgcatctct ggtgagtcag gactatgtca atggcaccga tcaggaagaa      240

attcgaaccg gtgttgatca gtgtatccag aagtttctgg atattgcaag acagacagaa      300

tgttttttct tacaaaaaag attgcagtta tctgtccaga aaccagagca agttatcaaa      360

gaggatgtgt cagaactaag gaatgaatta cagcggaaag atgcactagt ccagaagcac      420

ttgacaaagc tgaggcattg gcagcaggtg ctggaggaca tcaacgtgca gcacaaaaag      480

cccgccgaca tccctcaggg ctccttggcc tacctggagc aggcatctgc caacatccct      540

gcacctctga agccaacgtg agcaaagggc agaggcagtt ggcctatgag tgggctgatg      600

cgtgaggttg gccacacatt ccttcctgtg gacttgacat tttggaagaa ctctttgcca      660

gataatgagt tcattttagt tttatgctcc cattgaaaaa ttttccacta tttttataag      720

ctgttaattt cttgagtact ttataacatg tctgtagctt ggataaacca agtaagtatt      780

ttttttttgt ctttagcaaa gtttagactg tgaatatgat gacacagatt cttttttatg      840

gtggctttgc ttgttttaaa tttttgcatg acttttcatc tttttatgtg tgtttcctgt      900

agtttgatcc gaaggaaaag agtatagtag cctgagaatc aggagatggg agttttagtc      960

gtaggcctta tgataattac cccgcggtgg tgtgtagaaa agtatgtaaa tttgctctgt     1020

tttaagactt tgaactacct caagaagagg aatctaatac aatatttgta atgtttccag     1080

agctctcaga atgaggattt ttttgtaaat aggtcagaag acgatggaac tgtcctgggt     1140

tagtatagta atcttacagt aggatcctta ggttgatgct gacttctgtt tggggtatgt     1200

ttatatttta tgtggtgttt actttttttt tttgacatag aaggatatag tgggagcagt     1260

gatacgctaa cattcattac attctgcagt aatgaatctg tttaatgggt cagtcactgt     1320

tttcagtagc atgacagtgg ggtcataggt gagctgtgag gggctaaatc ttgctctgat     1380

tgtctctttc tgttttgagt tttgtttgcg tgtatcattt ttgttctaca ttttgggagg     1440

ggaaacattt tccgttaagg aaggttgttg ccagtggatt tgactccaag ggactagagt     1500

gtcgtggtgg gggtggggag gggctgcagg gtgatcattg gctactgagc ctccacagag     1560

agcatgtggt gccctgcctt tgggagggta ttttgctctc gttagttttg tgggcagcct     1620

cagattccct gttgagttgc tgttaagaaa tggagatttc tggctctcat tgggtaaggt     1680

tttctgagtt ttatatctta ttagatcaca tccctttacc cagaacaaat gcttcactgt     1740

cttctgattg gcagtactcc tgtggctttg tgccttgact cattttgttg tcttcagcct     1800

tgaaggcccc ttcccacatg gactgacatc cactcatgtg cctgatccct gaagcctccc     1860

agcacccatt cagttgcatc cccagggcac aggactttga tctcttctgt tgccctcgct     1920

aggttctccc tggtgggtta gtgctttgta tctgtctctc tgcccctcac taattctaca     1980

cccatgagaa ttagacatta ttctccttaa atatataagg accatataat ctgtatcttt     2040

ttggtgtgtg tatatggtat ctggcacatg gatctctgat taccagcctg acatcaacaa     2100

atcccctcag ttacaacgta taggttaaac aaagctttta aaagctcatg tggtatgacc     2160

tcaaggttgc taacctggtc actcatggta attagaaact ctgattggca gctttgtatt     2220

tcttgactaa aaacctaaat aaactgatta ggttttaggc gttctttcaa agaggttctt     2280

gagaagattg agaactatcc tatttggtgc ttagtgaaaa gattttgaat tactgtacgt     2340

accagttgtt gccatttctt tattaaattc agaagttttt ttgccaaata acaa           2394


<210> 251
<211> 2208
<212> DNA
<213> Homo sapiens

<400> 251
cgggagggtc ctcagctaaa gccaaaagca gatcaaagtg gtgggactcg cgtcgcggcc       60

gcggagacgt gaagctctcg aggctcctcc cgctgcgggt cggcgctcgc cctcgctctc      120

ctcgccctcc gccccggccc cggccccgcg cccgccatgg agaagactga gctgatccag      180

aaggccaagc tggccgagca ggccgagcgc tacgacgaca tggccacctg catgaaggca      240

gtgaccgagc agggcgccga gctgtccaac gaggagcgca acctgctctc cgtggcctac      300

aagaacgtgg tcgggggccg caggtccgcc tggagggtca tctctagcat cgagcagaag      360

accgacacct ccgacaagaa gttgcagctg attaaggact atcgggagaa agtggagtcc      420

gagctgagat ccatctgcac cacggtgctg gaattgttgg ataaatattt aatagccaat      480

gcaactaatc cagagagtaa ggtcttctat ctgaaaatga agggtgatta cttccggtac      540

cttgctgaag ttgcgtgtgg tgatgatcga aaacaaacga tagataattc ccaaggagct      600

taccaagagg catttgatat aagcaagaaa gagatgcaac ccacacaccc aatccgcctg      660

gggcttgctc ttaacttttc tgtattttac tatgagattc ttaataaccc agagcttgcc      720

tgcacgctgg ctaaaacggc ttttgatgag gccattgctg aacttgatac actgaatgaa      780

gactcataca aagacagcac cctcatcatg cagttgctta gagacaacct aacactttgg      840

acatcagaca gtgcaggaga agaatgtgat gcggcagaag gggctgaaaa ctaaatccat      900

acagggtgtc atccttcttt ccttcaagaa acctttttac acatctccat tccttattcc      960

acttggattt cctatagcaa agaaacccat tcatgtgtat ggaatcaact gtttatagtc     1020

ttttcacact gcagctttgg gaaaacttca ttccttgatt tgtgtttgtc ttggccttcc     1080

tggtgtgcag tactgctgta gaaaagtatt aatagcttca tttcatataa acataagtaa     1140

ctcccaaaca cttatgtaga ggactaaaaa tgtatctggt atttaagtaa tctgaaccag     1200

ttctgcaagt gactgtgttt tgtattactg tgaaaataag aaaatgtagt taattacaat     1260

ttaaagagta ttccacataa cttcttaatt tctacattcc ctcccttact cttcgggggt     1320

ttcctttcag taagcaactt ttccatgctc ttaatgtatt cctttttagt aggaatccgg     1380

aagtattaga ttgaatggaa aagcacttgc catctctgtc taggggtcac aaattgaaat     1440

ggctcctgta tcacatacgg aggtcttgtg tatctgtggc aacagggagt ttccttattc     1500

actctttatt tgctgctgtt taagttgcca acctcccctc ccaataaaaa ttcacttaca     1560

cctcctgcct ttgtagttct ggtattcact ttactatgtg atagaagtag catgttgctg     1620

ccagaataca agcattgctt ttggcaaatt aaagtgcatg tcatttctta atacactaga     1680

aaggggaaat aaattaaagt acacaagtcc aagtctaaaa ctttagtact tttccatgca     1740

gatttgtgca catgtgagag ggtgtccagt ttgtctagtg attgttattt agagagttgg     1800

accactattg tgtgttgcta atcattgact gtagtcccaa aaaagccttg tgaaaatgtt     1860

atgccctatg taacagcaga gtaacataaa ataaaagtac attttataaa ccatttacta     1920

tggctttgta acaattgcat acccatattt taagggacag gtgaatttac tactttctaa     1980

agtttattga tacttccctt ttatgtaaaa tgtagtagtg atacctatat ttccacattg     2040

tgcattgtga cacacttgtc tagggatgcc tggaagtgta taaaattgga ctgcatttct     2100

tagagtgttt tactatagat cagtctcatg ggccatctct tcctcagatg taaatgatat     2160

ctggttaagt gttatatgga ataaagtgga cattttaaaa ctagcaaa                  2208


<210> 252
<211> 1166
<212> DNA
<213> Homo sapiens

<400> 252
atgcacacat acgcgcgcgc acatgcacat aggcacacag agatacgcgc acacacacac       60

acaaacgcac tcagatttcc cggaccctgg ttttcctcct gtgacccttt cggggccggg      120

ctctcaccct aaagaagcag ccccgccctg gggtggcccc accctctctt gggacctgtc      180

ataagtcgga ccccgggcgc ccggctgcgc agtcccagcc gccttcccca ggcagtggaa      240

ccttcgggct cctgagcttc aggatggttc gtactaagac atggaccctg aagaagcact      300

ttgttggcta tcctactaat agtgactttg agttgaagac agctgagctc ccacccttaa      360

aaaatggaga ggtcctgctt gaagctttgt tcctcaccgt ggatccctac atgagagtgg      420

cagccaaaag attgaaggaa ggtgatacaa tgatggggca gcaagtggcc aaagttgtgg      480

aaagtaaaaa tgtagcccta ccaaaaggaa ctattgtact ggcttctcca ggctggacaa      540

cgcactccat ttctgatggg aaagatctgg aaaagctgct gacagagtgg ccagacacaa      600

taccactgtc tttggctctg gggacagttg gcatgccagg cctgactgcc tactttggcc      660

tacttgaaat ctgtggtgtg aagggtggag aaacagtgat ggttaatgca gcagctggag      720

ctgtgggctc agtcgtgggg cagattgcaa agctcaaggg ctgcaaagtt gttggagcag      780

tagggtctga tgaaaaggtt gcctaccttc aaaagcttgg atttgatgtc gtctttaact      840

acaagacggt agagtctttg gaagaaacct tgaagaaagc gtctcctgat ggttatgatt      900

gttattttga taatgtaggt ggagagtttt caaacactgt tatcggccag atgaagaaat      960

ttggaaggat tgccatatgt ggagccatct ctacatataa cagaaccggc ccacttcccc     1020

caggcccacc cccagagatt gttatctatc aggagcttcg catggaagct tttgtcgtct     1080

accgctggca aggagatgcc cgccaaaaag ctctgaagga cttgctgaaa tgggtcttag     1140

agcttcccta ctttgtaatt gactga                                          1166


<210> 253
<211> 4336
<212> DNA
<213> Homo sapiens

<400> 253
agttcgccct gccggaaagc agcacgccgc cgcggcattt tacgacgtcg gcggtgacag       60

gccctgggac tctgggaata cccagcttcc tccccgcaac ccggtgaaag ccaacgcaat      120

gttcggtgcg ggggacgagg acgacaccga tttcctctcg ccgagcggcg gtgccagatt      180

ggcctcactt tttggactgg atcaggcagc tgctggccat ggaaatgaat ttttccagta      240

cacagcccca aaacagccta agaaaggcca gggaacggca gcaacaggaa atcaggcaac      300

accaaaaaca gcaccagcca ccatgagcac tcccacaata ctggtcgcaa cagcagtcca      360

tgcatatcga tacacaaatg gtcaatatgt aaagcagggc aaatttggtg ctgcagttct      420

ggggaaccac acagccagag agtataggat tcttctttat atcagtcaac aacagccagt      480

tacggttgct aggattcatg tgaactttga gctaatggtt cggcccaata actatagcac      540

cttttatgat gaccagagac agaactggtc catcatgttt gagtcggaaa aggctgctgt      600

ggagttcaat aagcaggtgt gcattgctaa gtgcaacagt acctcttccc tggatgcagt      660

gctctcccag gacctcattg tggcagacgg ccctgctgta gaagttggag attctttgga      720

agtggcctat accggctggc tctttcagaa tcatgtgctg ggccaggttt tcgactccac      780

tgctaacaaa gataagttgc ttcgcttgaa gttaggatca ggaaaagtca tcaagggctg      840

ggaggatgga atgctgggca tgaaaaaagg aggaaagcga ttgcttattg tccctccagc      900

ctgtgctgtt ggctcagaag gggtaatagg ctggactcaa gcaacggact cgatcctggt      960

gttcgaggtg gaggttaggc gggtgaagtt tgccagagat tctggctctg atggtcacag     1020

tgttagttcc cgcgattctg cagctccgtc tcccatccct ggtgctgaca acctctctgc     1080

tgatcctgtt gtgtcaccac ccacatcaat acctttcaaa tcaggggagc cagctcttcg     1140

taccaaatct aactccctca gtgaacaact tgcaataaat acaagtcccg atgcagtcaa     1200

agccaagttg atctctcgga tggctaaaat gggccagccc atgctgccca tccttccacc     1260

acagctggat tccaatgatt cagaaatcga agatgtgaac actctgcaag gaggtgggca     1320

gcctgtggtg actccgtccg tccagccctc tcttcatccg gcccatccag cgttaccaca     1380

gatgacctca caggcacctc agccatctgt tactgggctc caggcacctt ctgctgcctt     1440

aatgcaagtg tcatctctcg attcccactc agctgtatct ggaaatgccc aatcctttca     1500

gccctatgca ggtatgcaag cctacgctta tccccaggca tctgccgtca cctcccagct     1560

gcagcccgtt cggcctttgt acccagcacc gctctctcag cctccccatt tccaaggatc     1620

aggtgatatg gcttcatttc tcatgactga agcccggcaa cataacactg aaattcgaat     1680

ggcagtcagc aaagtggctg ataaaatgga tcatctcatg actaaggttg aagagttaca     1740

gaaacatagt gctggcaatt ccatgcttat tcctagcatg tcagttacaa tggaaacaag     1800

catgattatg agcaacatcc agcgaatcat tcaggaaaat gaaagattga agcaagagat     1860

ccttgaaaag agcaatcgga tagaagaaca gaatgacaag attagtgaac taattgaacg     1920

aaatcagagg tatgttgagc agagtaacct gatgatggag aagaggaaca actcacttca     1980

gacagccaca gaaaacacac aggcaagagt attgcatgct gaacaagaga aggccaaggt     2040

gacagaggag ttagcagcgg ccactgcaca ggtctctcat ctgcagctga aaatgactgc     2100

tcaccaaaaa aaggaaacag agctgcagat gcagctgaca gaaagcctga aggagacaga     2160

tcttctcagg ggccagctca ccaaagtgca ggcaaagctc tcagagctcc aagaaacctc     2220

tgagcaagca cagtccaaat tcaaaagtga aaagcagaac cggaaacaac tggaactcaa     2280

ggtgacatcc ctggaggagg aactgactga ccttcgagtt gagaaggagt ccttggaaaa     2340

gaacctctca gaaaggaaaa agaagtcagc tcaagagcgt tctcaggccg aggaggagat     2400

agatgaaatt cgcaagtcat accaggagga attggacaaa cttcgacagc tcttgaaaaa     2460

gactcgagtg tccacagacc aagcagctgc agagcagctg tctttagtac aggctgagct     2520

acagacccag tgggaagcaa aatgtgaaca tttgttggcc tccgccaagg atgagcacct     2580

gcagcagtac caggaggtgt gcgcacagag agatgcctac cagcagaagc tggtacaact     2640

tcaggaaaag tgtttagccc tccaggccca aatcacagct ctcaccaagc aaaatgaaca     2700

gcacatcaag gaactagaga agaacaagtc ccagatgtct ggggttgaag ctgctgcatc     2760

tgacccctca gagaaggtca agaagatcat gaaccaggtg ttccagtcct tacggagaga     2820

gtttgagctg gaggaatctt acaatggcag gaccattctg ggaaccatca tgaatacgat     2880

caagatggtg actcttcagc tgttaaacca acaggagcaa gagaaggaag agagcagcag     2940

tgaagaagaa gaagaaaaag cagaagagcg gccacgaaga ccttcccagg agcagtcagc     3000

ctcagccagt tctgggcagc ctcaagcacc cctgaatagg gagaggccag agtcccccat     3060

ggtgccctca gagcaggtgg tcgaggaagc tgtcccgttg cctcctcagg ccctcaccac     3120

ttcccaggat ggacacagaa ggaaagggga ctcagaagct gaggcactct cagagataaa     3180

agatggttcc cttccacccg aactgtcttg catcccatcc cacagagttc tagggccccc     3240

gacttcaatt ccacctgagc ccctaggccc tgtatccatg gactctgagt gtgaggagtc     3300

acttgctgcc agcccaatgg cagctaagcc cgacaaccca tcaggaaagg tctgtgtcag     3360

ggaagtagca ccagatggcc cactacaaga aagctccaca agactgtccc tgacttcaga     3420

ccccgaggag ggggacccac tggccttagg gcctgaaagc ccaggagagc ctcagcctcc     3480

acagctcaag aaagatgatg tcactagctc caccggtccc cacaaggagc tgtcaagcac     3540

agaggcaggt tccacagttg caggagcagc cctcagaccc agccatcatt cccagcgttc     3600

cagtctctct ggggatgaag aggatgaact gtttaaaggg gcaactctga aagctctgag     3660

gcccaaagca cagcctgagg aggaggatga agacgaggtg agcatgaagg gacgcccgcc     3720

cccaacgccc ctttttggag atgatgatga tgacgatgac attgactggc tgggatgaag     3780

acccaggaaa ctggtgcaaa ggtttctctg caacccttcc ctaagcatga ttttgcacag     3840

ccaaccctgg gtctaggcga accacagggt gaggtcaagg tgagcattct gggaacaata     3900

tttgggctca gagggtgggt tggccacctt ctgagcccca cccccgccag acctggtgaa     3960

gaggatcata accctgtctt caagaacact gggatttcag cagcaagttg gaagaaggac     4020

tggtaggttc ccctccaagc cagtcacctg taagagtcct gtcctctgcc agacttttta     4080

atctcttcat taactctcag actgacctgg gagccctcct ctacctgaat ccagtgctca     4140

actgtgcccc ggcaacaaga cctgggctga ggtctccctg gtagaactaa gggagattac     4200

accatctaaa tcccagtgca gtcaacagcc tggcctatag tcctgggaca tgtatcttct     4260

tctttgcctt aaatctgata caagaggtca atgactttga aaataaaact aaaataaatg     4320

tctataatga aacttg                                                     4336


<210> 254
<211> 7431
<212> DNA
<213> Homo sapiens

<400> 254
gttttgatga acacctggct ttattcttgc aatgaagaaa ggttctcaac aaaaaatatt       60

ctccaaagca aagataccat catcatctca ctctcctatc ccatcatcta tgtccaatat      120

gagatctagg tcactttcac ctttgattgg atcagagact ctaccttttc attctggagg      180

acagtggtgt gagcaagttg agattgcaga tgaaaacaat atgcttttgg actatcaaga      240

ccataaagga gctgattcac atgcaggagt tagatatatt acagaggccc tcattaaaaa      300

acttactaaa caggataatt tggctttgat aaaatctctg aacctttcac tttctaaaga      360

cggtggcaag aaatttaagt atattgagaa tttggaaaaa tgtgttaaac ttgaagtact      420

gaatctcagc tataatctaa tagggaagat tgaaaagttg gacaagctgt taaaattacg      480

tgaactcaac ttatcatata acaaaatcag caaaattgaa ggcatagaaa atatgtgtaa      540

tctgcaaaag cttaaccttg caggaaatga aattgagcat attccagtat ggttagggaa      600

gaagttaaaa tctttgcgag tcctcaattt gaaaggcaac aagatatcat cgctccaaga      660

tataagcaag ttgaaaccgc ttcaagattt gatttctctg atcctagttg aaaatccagt      720

tgtgaccctt cctcattacc tccagtttac cattttccac ctccgttcat tggaaagttt      780

ggaaggtcag ccagtaacca ctcaggatag acaggaggct tttgagagat tcagtttaga      840

agaggtagaa agactggaaa gagacctaga aaaaaagatg atagaaactg aagagcttaa      900

gagcaaacaa acaaggttcc ttgaggaaat taaaaatcaa gataaattga ataaatcatt      960

aaaagaggag gccatgttac agaaacagag ctgtgaggaa ctcaagagtg acttaaacac     1020

aaaaaatgaa ttgctaaaac agaagaccat agaattaaca cgagcatgtc agaagcaata     1080

tgagctggaa caggaattgg ccttttataa aattgatgct aaatttgagc cactaaatta     1140

ttatccatca gagtatgctg aaattgataa agccccagat gaaagccctt acattggcaa     1200

atccagatac aagagaaata tgtttgccac agagagttat attattgaca gtgctcaggc     1260

agtacagatc aagaagatgg agccagatga acaacttaga aatgatcaca tgaacttgag     1320

aggccacaca ccactggaca cgcaactgga agacaaagaa aaaaaaataa gtgcagcaca     1380

aactcgacta tcagaactgc atgatgaaat agaaaaggca gaacaacaaa ttttgagagc     1440

tactgaagaa tttaaacaac tggaagaagc tatacaacta aaaaagattt cagaagcagg     1500

gaaagacctt ctttacaagc agttgagtgg tagactacaa cttgtaaata aattacgcca     1560

ggaagctctg gatctagaac tgcagatgga aaagcaaaag caggaaattg ccggaaagca     1620

gaaggagatt aaggacctgc aaatagccat agatagcctg gattccaaag acccaaaaca     1680

ttcccatatg aaggctcaaa agagcggtaa agaacaacag cttgacatta tgaacaagca     1740

gtaccaacaa cttgaaagtc gtttggatga gatactttct agaattgcta aggaaacgga     1800

agagattaag gaccttgaag aacagcttac tgaaggccag atagcagcaa atgaagccct     1860

gaagaaggat ttagaaggtg ttatcagtgg gttgcaagaa tacctgggga ccattaaagg     1920

ccaggcaact caggcccaga atgagtgcag gaagctgcgg gatgagaaag agacattgtt     1980

gcagagattg acagaagtcg agcaggagag agaccagctg gaaatagttg ccatggatgc     2040

agaaaatatg aggaaggagc ttgcagagct agaaagtgcc ctccaagagc agcatgaggt     2100

gaatgcatct ttgcagcaga cccagggaga tctcagtgcc tatgaagctg agctagaggc     2160

tcggctaaac ctaagggatg ctgaagccaa ccagctcaag gaagagttgg aaaaagtaac     2220

aagacttacc cagttagaac aatcagccct tcaagcagaa cttgagaagg aaaggcaagc     2280

cctcaagaat gcccttggaa aagcccagtt ctcagaagaa aaggagcaag agaacagtga     2340

gctccatgca aaacttaaac acttgcagga tgacaataat ctgttaaaac agcaacttaa     2400

agatttccag aatcacctta accatgtggt tgatggtttg gttcgtccag aagaagtggc     2460

agctcgtgtg gatgagctaa gaagaaaact gaaattagga actggggaaa tgaacatcca     2520

tagtccttca gatgtcttag ggaaaagtct tgctgattta cagaaacaat tcagtgaaat     2580

tcttgcacgc tccaagtggg aaagagatga agcacaagtt agagagagaa aactccaaga     2640

agaaatggct ctgcagcaag agaaactggc aactggacaa gaagagttca ggcaggcctg     2700

tgagagagcc ctggaagcaa gaatgaattt tgataagagg caacatgaag caagaatcca     2760

gcaaatggag aatgaaattc actatttgca agaaaatcta aaaagtatgg aggaaatcca     2820

aggccttaca gatctccaac ttcaggaagc tgatgaagag aaggagagaa ttctggccca     2880

actccgagag ttagagaaaa agaagaaact tgaagatgcc aaatctcagg agcaagtttt     2940

tggtttagat aaagaactga agaaactaaa gaaagccgtg gccacctctg ataagctagc     3000

cacagctgag ctcaccattg ccaaagacca gctgaagtcc cttcatggaa ctgttatgaa     3060

aattaaccag gagcgagcag aggagttgca ggaagcagag aggttcagca gaaaggcagc     3120

acaagcagcc agagatctca cccgagcaga agctgagatc gaactcctgc agaatctcct     3180

caggcagaag ggggagcagt ttcgacttga gatggagaaa acaggtgtag gtactggagc     3240

aaactcacag gtcctagaaa ttgagaaact gaatgagaca atggaacgac aaaggacaga     3300

gattgcaagg ctgcagaatg tactagacct cactggaagt gacaacaaag gaggctttga     3360

aaatgtttta gaagaaattg ctgaacttcg acgtgaagtt tcttatcaga atgattacat     3420

aagcagcatg gcagatcctt tcaaaagacg aggctattgg tactttatgc caccaccacc     3480

atcatcaaaa gtttccagcc atagttccca ggccaccaag gactctggtg ttggccttaa     3540

gtactcagcc tcaactcctg ttagaaaacc acgccctggg cagcaggatg ggaaggaagg     3600

cagtcaacct ccccctgcct caggatactg ggtttattct cccatcagga gtgggttaca     3660

taaactgttt ccaagtagag atgcagacag tggaggagat agtcaggaag agagtgagct     3720

ggatgaccaa gaagaacccc catttgtgcc tcctcctgga tacatgatgt atactgtgct     3780

tcctgatggt tctcctgtac cccagggcat ggccctgtat gcaccacctc ctcccttgcc     3840

aaacaatagc cgacctctca cccctggcac tgttgtttat ggcccacctc ctgctggggc     3900

ccccatggtg tatgggcctc caccccccaa cttctccatc cccttcatcc ctatgggtgt     3960

gctgcattgc aacgtccctg aacaccataa cttagagaat gaagtttcta gattagaaga     4020

cataatgcag catttaaaat caaagaagcg ggaagaaagg tggatgagag catccaagcg     4080

gcagtcggag aaagaaatgg aagaactgca tcataatatt gatgatcttt tgcaagagaa     4140

gaaaagctta gagtgtgaag tagaagaatt acatagaact gtccagaaac gtcaacagca     4200

aaaggacttc attgatggaa atgttgagag tcttatgact gaactagaaa tagaaaaatc     4260

actcaaacat catgaagata ttgtagatga aattgagtgc attgagaaga ctcttctgaa     4320

acgtcgctca gagctcaggg aagctgaccg actcctggca gaggctgaga gtgaactttc     4380

atgcactaaa gaaaagacaa aaaatgctgt tgaaaagttc actgatgcca agagaagttt     4440

attgcaaact gagtcagatg ctgaggaatt agaaaggaga gctcaggaaa ctgctgttaa     4500

cctcgtcaaa gctgatcagc agctaagatc gctccaggct gatgcaaagg atttggagca     4560

gcacaaaatc aagcaagaag aaatcttgaa agaaataaac aaaattgtag cagcaaaaga     4620

ctcagacttc caatgtttaa gcaagaagaa ggaaaaactg acagaagagc ttcagaaact     4680

acagaaagac atagagatgg cagaacgcaa tgaggatcac cacctgcagg tccttaaaga     4740

atctgaggtg cttcttcagg ccaaaagagc cgagctggaa aagctgaaaa gccaggtgac     4800

aagtcagcag caggagatgg ctgtcttgga caggcagtta gggcataaaa aggaggagct     4860

gcatctactc caaggaagca tggtccaggc aaaagctgac ctccaggaag ctctgagact     4920

gggagagact gaagtaactg agaagtgcaa tcacattagg gaagtaaaat ctcttctgga     4980

agaactgagt tttcagaaag gagaactaaa tgttcagatt agtgaaagaa aaactcaact     5040

tacacttata aagcaggaaa ttgaaaaaga ggaagaaaat cttcaggttg ttttaaggca     5100

gatgtctaaa cataaaaccg aactaaagaa tattctggac atgttgcaac ttgaaaacca     5160

tgagctacaa ggtttgaagc tacaacatga ccaaagggta tctgaattag agaagactca     5220

ggtggcagtg ctagaggaga aactggagtt agagaatttg cagcagatat cccagcagca     5280

gaaaggggaa atagagtggc agaagcagct ccttgagagg gataaacgag aaatagaacg     5340

aatgactgct gagtcccgag ctttacaatc gtgtgttgag tgtttgagca aagaaaagga     5400

agatctccaa gagaaatgtg acatttggga aaaaaagttg gcacaaacca aaagggtttt     5460

agcagcagca gaagaaaata gcaaaatgga gcaatcaaac ttagaaaagt tggaattgaa     5520

tgtcagaaaa ctgcagcagg aactagacca actaaacaga gacaagttgt cactgcataa     5580

cgacatttca gcaatgcaac agcagctcca agaaaaacga gaagcagtaa actcactgca     5640

ggaggaacta gctaatgtcc aagaccattt gaacctagca aaacaggacc tgcttcacac     5700

caccaagcat caggatgtgt tgctcagtga gcagacccga ctccagaagg acatcagtga     5760

atgggcaaat aggtttgaag actgtcagaa agaagaggag acaaaacaac aacaacttca     5820

agtgcttcag aatgagattg aagaaaacaa gctcaaacta gtccaacaag aaatgatgtt     5880

tcagagactc cagaaagaga gagaaagtga agaaagcaaa ttagaaacca gtaaagtgac     5940

actgaaggag caacagcacc agctggaaaa ggaattaaca gaccagaaaa gcaaactgga     6000

ccaagtgctc tcaaaggtgc tggcagctga agagcgtgtt aggactctgc aggaagagga     6060

gaggtggtgt gagagcctgg agaagacact ctcccaaact aaacggcagc tttcagaaag     6120

ggagcagcaa ttggtggaga aatcaggtga gctgttggcc ctccagaaag aggcagattc     6180

tatgagggca gacttcagcc ttctgcggaa ccagttcttg acagaaagaa agaaagctga     6240

gaagcaggtg gccagcctga aggaagcact taagatccag cggagccagc tggagaaaaa     6300

ccttcttgag caaaaacagg agaacagctg catacaaaag gaaatggcaa caattgaact     6360

ggtagcccag gacaaccatg agcgggccag gcgcctgatg aaggagctca accagatgca     6420

gtatgagtac acggagctca agaaacagat ggcaaaccaa aaagatttgg agagaagaca     6480

aatggaaatc agtgatgcaa tgaggacact taaatctgag gtgaaggatg aaatcagaac     6540

cagcttgaag aatcttaatc agtttcttcc agaactacca gcagatctag aagctatttt     6600

ggaaagaaac gaaaacctag aaggagaatt ggaaagcttg aaagagaacc ttccatttac     6660

catgaatgag ggaccttttg aagaaaaact gaacttttcc caagttcaca taatggatga     6720

acactggcgt ggagaagcac tccgggagaa actgcgtcac cgggaagacc gactcaaggc     6780

ccaactccga cactgtatgt ccaagcaagc agaagtatta attaaaggaa agcggcagac     6840

agagggcact ttacacagtt tgaggagaca agtagatgct ttaggggaat tggtcaccag     6900

cacctctgca gattcagcgt catcacccag tctgtctcag ctggagtctt ccctcacaga     6960

ggactctcaa cttggacaaa atcaggaaaa gaatgcctca gccagatgag gaatactgtc     7020

ttgtgtaaat atattcaagg aaaacacctc cactacctca ctgacttcat aattggaatg     7080

tcacatggtt tttttaatca agatgcagtg aactgagatt ctgaaactcc actgtagttt     7140

actttgcctg taccattaat gccaatgttt ttataaatca cttgtacata gtacatatgg     7200

gaatagttgc atatgggaat ttaaaccaac atgtggctga gccttttttt ttttaatctt     7260

cgtaacatgt ttaaaaaaaa acagtgattt taactgcata tttgaaccta caaactggta     7320

aatcttatta acaaaaagaa tgtacttaag gccctcttta tttatagtgt cgagttattt     7380

ttgaattttg cttaaaatct atttttcata tgaaaataaa agataacaat c              7431


<210> 255
<211> 4087
<212> DNA
<213> Homo sapiens

<400> 255
gcatgatggg agagtgtgtg gagtgggcgg ggggtctccg cggaggaggt ggaggaggcg       60

gcggcggcgg cggaagaggg cggagggtag tgggatgggg gtcccgcggc agcggtgaaa      120

ctccgggtgg gcgtccatgg tgctgctgcg ctgacagggc tgtgagcagc cggccttccg      180

ctctcaccag ttccgcgtcg gaatagacgg tccttccccg gggagtcagt tcctccccgg      240

gcccctgagc catgcccatc gcagccgccc cgaaggagcc aggtgtaaat taattatttg      300

aaagcaactg aacaatggag ccagacatca ttcgaatgta ctcttcatcc ccaccaccat      360

tagacaatgg agcagaggat gatgatgatg atgaatttgg ggaatttggt gggttttcag      420

aagttagccc ttctggtgta gggtttgttg atttcgatac accagattat actcgtccca      480

aggaagagtt tgtaccttca aaccatttta tgccaattca tgaattctca gaaaatgtag      540

atagccttac aagctttaag tccattaaaa atggtaatga taaggacatc actgctgaac      600

tttctgctcc tgtgaaagga cagtctgatg ttttactttc taccaccagc aaagaaataa      660

tttcatctga aatgttagct acttccattg atggcatgga aagaccagga aatttaaata      720

aagtagtgga gcagagacag aatgttggaa cacttgaaag tttctctcca ggagatttta      780

gaactaatat gaatgttgtt catcaaaaca agcagttaga gagctgcaat ggtgaaaagc      840

ctccttgtct ggagattcta acaaatgggt ttgcagtgtt ggaaactgta aatcctcagg      900

gaacagatga tctggacaat gtagctgatt caaagggacg gaagcctctt agcactcata      960

gcactgagta taatttagac tctgtaccta gtcctgctga ggaatttgca gattttgcca     1020

cattttccaa aaaggaaagg atacaattag aagaaataga atgtgcagtt ttaaatgata     1080

gagaagcact aaccattcgg gaaaacaata aaattaatag agtcaatgaa ctgaattctg     1140

taaaagaagt ggctttgggt agaagcttgg ataacaaagg agacactgat ggagaggatc     1200

aggtttgtgt ttcagaaata agcatagtga ctaacagagg tttcagtgtt gaaaaacaag     1260

gccttccaac actgcaacag gatgaatttt tacagtcagg tgttcagtca aaggcttgga     1320

gtttggtaga ctcagctgat aattcagaag ccattaggag agaacaatgt aaaactgaag     1380

aaaaacttga cttacttact tctaaatgtg ctcacctatg catggattct gttaaaactt     1440

ctgatgatga agttggttct cccaaagaag aaagtagaaa gtttactaat ttccaaagcc     1500

caaacattga ccccacagaa gaaaatgatt tggatgattc tttaagtgta aaaaatggtg     1560

atagtagtaa tgactttgtg acttgcaatg atatcaatga agatgatttt ggtgattttg     1620

gtgactttgg ctctgccagt ggctcaactc caccttttgt tactggtact caagattcaa     1680

tgagtgatgc cacttttgaa gagtcttcag agcactttcc acattttagt gaaccaggtg     1740

atgactttgg agaatttggg gatataaatg ctgtttcttg ccaagaggag acaatattaa     1800

caaagtcaga cctaaaacag acttctgata atttatcaga agaatgtcaa ttggcaagaa     1860

aatctagtgg aacaggcact gaacctgttg caaaacttaa aaatgggcaa gaaggtgaga     1920

ttggacattt tgattctgtg ccaaatattc aggatgactg caatggtttt caagactctg     1980

atgattttgc agacttcagt tcagctggtc ctagccaagt tgtagattgg aatgcttttg     2040

aggatgaaca aaaagatagt tgttcttggg ctgcttttgg agaccagcag gctactgaat     2100

ctcatcatcg aaaggaagcc tggcagtcac ataggacaga tgaaaatatt gatactccag     2160

gaacccccaa aacgcacagt gtaccttcag caacttccaa aggagcagtt gctagtggcc     2220

atttacagga atcagccact tcagttcaga cagctttatt aaaccgcctg gagcgaattt     2280

tcgaagcatg ttttccttcc atacttgtcc ctgatgctga agaggaagtt acttccctga     2340

agcacttgct ggaaacaagc actttgccaa taaaaacgag agaggcctta cctgaaagtg     2400

gggaattgct agatgtgtgg actgagctac aggatatcca tgatgcacat ggcttgagat     2460

accagtgggg cggctcccat agcaacaaga agcttttgtc ctccttggga atagacaccc     2520

gaaacattct cttcacgggc aataagaagc agcctgttat agtgcccatg tatgcagcag     2580

gattgggtat gttagagccc accaaggaac cactgaaacc actttctgct gcagaaaaaa     2640

tagcttccat cggtcagaca gccaccatgt caccagatat gaacacatgt acatctgatc     2700

agttccagga gtctctacca cccgtccagt ttgactggag tagcagtggc cttactaacc     2760

ctttagatgc tagtggaggt tccactcttc tgaaccttga tttctttggg cccgtggatg     2820

acagtagctc tagcagcagc accacaatcc caggtgtgga tccggagttg tatgagttaa     2880

caacttctaa gctggaaatc tccacctcaa gcctcaaagt gactgatgca tttgcaagac     2940

tcatgtctac agtagagaag acaagcacat ctaccaggaa accgaaaaga gaagagcacc     3000

taagtgaaga agctatcaag gtgatcgctg gccttcctga cttaacattc atgcatgcca     3060

aggtgttgat gttcccagcc acgttaacac cttccacaag ctctcaagaa aaagcagacg     3120

gataactgat gtgaattgga cagtttctat tgcttttcct tttttccatc ccttccctac     3180

catcaaaagc atacctgctc taattaaaaa aaaaaaaaaa aaaaattcaa gttcagctga     3240

tttgttggta agccgcacta gaaaggtata catagtaatg tatatttatt tacatactga     3300

agtcctaaat ttatattaga aaaatgtaaa taatcggggg taaacatttt tgaagattta     3360

ttctttttgt gttgctgggg tgtatacatt tatgtctttg tgaaatacac tggtggtgtc     3420

cttcttacaa aacttttgaa ataaaaaaaa aactcaaatc ttcactgtct gtgaaatccc     3480

cttcagtctt ttcagattgc attgactgtc ctcttgattt ttcatattac atgtcaaatt     3540

acttttgcta tcataaataa gctccaaagt cccccattta attttttttt aattttgtgt     3600

atgatgggtt tcagatctgg cttttgttaa cattttgggg cttttttaat cttttcaatc     3660

tggcgtattg ctgtttgacc ttttgcaagg tacttaattg ctcttttgtt atagggtatg     3720

gatcattgtc agaacttgat tggaggggtt taaagagatt gtgtctgttt aaaatcagta     3780

tgattcagag aaggaccaaa ttatatgaat gtcttacaat ggaatttact tgttactgat     3840

ttttttgttc tattgtacca ctattttttg aggattttgc acagtgtaaa atgacataat     3900

catagattgc tatggtttag gctgtatata cagtgaaaac tatgggtttt aaatgtttgg     3960

ggaaattcct atggaaaaaa gagagacatg tagaagaacc tctaacaagg ttaatgtgca     4020

tgcccaaggt cttttgaaat ttcagtgtgt aaatttcctt ttagcttata caaaaataaa     4080

ataattt                                                               4087


<210> 256
<211> 4014
<212> DNA
<213> Homo sapiens

<400> 256
gcatgatggg agagtgtgtg gagtgggcgg ggggtctccg cggaggaggt ggaggaggcg       60

gcggcggcgg cggaagaggg cggagggtag tgggatgggg gtcccgcggc agcggtgaaa      120

ctccgggtgg gcgtccatgg tgctgctgcg ctgacagggc tgtgagcagc cggccttccg      180

ctctcaccag ttccgcgtcg gaatagacgg tccttccccg gggagtcagt tcctccccgg      240

gcccctgagc catgcccatc gcagccgccc cgaaggagcc aggtgtaaat taattatttg      300

aaagcaactg aacaatggag ccagacatca ttcgaatgta ctcttcatcc ccaccaccat      360

tagacaatgg agcagaggat gatgatgatg atgaatttgg ggaatttggt gggttttcag      420

aagttagccc ttctggtgta gggtttgttg atttcgatac accagattat actcgtccca      480

aggaagagtt tgtaccttca aaccatttta tgccaattca tgaattctca gaaaatgtag      540

atagccttac aagctttaag tccattaaaa atggtaatga taaggacatc actgctgaac      600

tttctgctcc tgtgaaagga cagtctgatg ttttactttc taccaccagc aaagaaataa      660

tttcatctga aatgttagct acttccattg atggcatgga aagaccagga aatttaaata      720

aagtagtgga gcagagacag aatgttggaa cacttgaaag tttctctcca ggagatttta      780

gaactaatat gaatgttgtt catcaaaaca agcagttaga gagctgcaat ggtgaaaagc      840

ctccttgtct ggagattcta acaaatgggt ttgcagtgtt ggaaactgta aatcctcagg      900

gaacagatga tctggacaat gtagctgatt caaagggacg gaagcctctt agcactcata      960

gcactgagta taatttagac tctgtaccta gtcctgctga ggaatttgca gattttgcca     1020

cattttccaa aaaggaaagg atacaattag aagaaataga atgtgcagtt ttaaatgata     1080

gagaagcact aaccattcgg gaaaacaata aaattaatag agtcaatgaa ctgaattctg     1140

taaaagaagt ggctttgggt agaagcttgg ataacaaagg agacactgat ggagaggatc     1200

aggtttgtgt ttcagaaata agcatagtga ctaacagagg tttcagtgtt gaaaaacaag     1260

gccttccaac actgcaacag gatgaatttt tacagtcagg tgttcagtca aaggcttgga     1320

gtttggtaga ctcagctgat aattcagaag ccattaggag agaacaatgt aaaactgaag     1380

aaaaacttga cttacttact tctaaatgtg ctcacctatg catggattct gttaaaactt     1440

ctgatgatga agttggttct cccaaagaag aaagtagaaa gtttactaat ttccaaagcc     1500

caaacattga ccccacagaa gaaaatgatt tggatgattc tttaagtgta aaaaatggtg     1560

atagtagtaa tgactttgtg acttgcaatg atatcaatga agatgatttt ggtgattttg     1620

gtgactttgg ctctgccagt ggctcaactc caccttttgt tactggtact caagattcaa     1680

tgagtgatgc cacttttgaa gagtcttcag agcactttcc acattttagt gaaccaggtg     1740

atgactttgg agaatttggg gatataaatg ctgtttcttg ccaagaggag acaatattaa     1800

caaagtcaga cctaaaacag acttctgata atttatcaga agaatgtcaa ttggcaagaa     1860

aatctagtgg aacaggcact gaacctgttg caaaacttaa aaatgggcaa gaaggtgaga     1920

ttggacattt tgattctgtg ccaaatattc aggatgactg caatggtttt caagactctg     1980

atgattttgc agacttcagt tcagctggtc ctagccaagt tgtagattgg aatgcttttg     2040

aggatgaaca aaaagatagt tgttcttggg ctgcttttgg agaccagcag gctactgaat     2100

ctcatcatcg aaaggaagcc tggcagtcac ataggacaga tgaaaatatt gatactccag     2160

gaacccccaa aacgcacagt gtaccttcag caacttccaa aggagcagtt gctagtggcc     2220

atttacagga atcagccact tcagttcaga cagctttatt aaaccgcctg gagcgaattt     2280

tcgaagcatg ttttccttcc atacttgtcc ctgatgctga agaggaagtt acttccctga     2340

agcacttgct ggaaacaagc actttgccaa taaaaacgag agaggcctta cctgaaagtg     2400

gggaattgct agatgtgtgg actgagctac aggatatcca tgatgcacat ggcttgagat     2460

accagtgggg cggctcccat agcaacaaga agcttttgtc ctccttggga atagacaccc     2520

gaaacattct cttcacgggc aataagaagc agcctgttat agtgcccatg tatgcagcag     2580

gattgggtat gttagagccc accaaggaac cactgaaacc actttctgct gcagaaaaaa     2640

tagcttccat cggtcagaca gccaccatgt caccagatat gaacacatgt acatctgatc     2700

agttccagga gtctctacca cccgtccagt ttgactggag tagcagtggc cttactaacc     2760

ctttagatgg tgtggatccg gagttgtatg agttaacaac ttctaagctg gaaatctcca     2820

cctcaagcct caaagtgact gatgcatttg caagactcat gtctacagta gagaagacaa     2880

gcacatctac cagtaggaaa ccgaaaagag aagagcacct aagtgaagaa gctatcaagg     2940

tgatcgctgg ccttcctgac ttaacattca tgcatgccaa ggtgttgatg ttcccagcca     3000

cgttaacacc ttccacaagc tctcaagaaa aagcagacgg ataactgatg tgaattggac     3060

agtttctatt gcttttcctt ttttccatcc cttccctacc atcaaaagca tacctgctct     3120

aattaaaaaa aaaaaaaaaa aaaattcaag ttcagctgat ttgttggtaa gccgcactag     3180

aaaggtatac atagtaatgt atatttattt acatactgaa gtcctaaatt tatattagaa     3240

aaatgtaaat aatcgggggt aaacattttt gaagatttat tctttttgtg ttgctggggt     3300

gtatacattt atgtctttgt gaaatacact ggtggtgtcc ttcttacaaa acttttgaaa     3360

taaaaaaaaa actcaaatct tcactgtctg tgaaatcccc ttcagtcttt tcagattgca     3420

ttgactgtcc tcttgatttt tcatattaca tgtcaaatta cttttgctat cataaataag     3480

ctccaaagtc ccccatttaa ttttttttta attttgtgta tgatgggttt cagatctggc     3540

ttttgttaac attttggggc ttttttaatc ttttcaatct ggcgtattgc tgtttgacct     3600

tttgcaaggt acttaattgc tcttttgtta tagggtatgg atcattgtca gaacttgatt     3660

ggaggggttt aaagagattg tgtctgttta aaatcagtat gattcagaga aggaccaaat     3720

tatatgaatg tcttacaatg gaatttactt gttactgatt tttttgttct attgtaccac     3780

tattttttga ggattttgca cagtgtaaaa tgacataatc atagattgct atggtttagg     3840

ctgtatatac agtgaaaact atgggtttta aatgtttggg gaaattccta tggaaaaaag     3900

agagacatgt agaagaacct ctaacaaggt taatgtgcat gcccaaggtc ttttgaaatt     3960

tcagtgtgta aatttccttt tagcttatac aaaaataaaa taatttaaaa gaaa           4014


<210> 257
<211> 1953
<212> DNA
<213> Homo sapiens

<400> 257
gggagtatgg gcttagaagc cggaagtggg ttgacgtagc ccggaagggg aatacttcca       60

agttgtagtg ttgttgtttt cagcctgctg ctgctgctgc tgttgcggct aggggaaccg      120

tcgtggggaa ggatggtgtg cgaaaaatgt gaaaagaaac ttggtactgt tatcactcca      180

gatacatgga aagatggtgc taggaatacc acagaaagtg gtggaagaaa gctgaatgaa      240

aataaagctt tgacttcaaa aaaagcaaga tttgatccat atggaaagaa taagttctcc      300

acttgtagaa tttgtaaaag ttctgtgcac caaccaggtt ctcattactg ccagggctgt      360

gcctacaaaa aaggcatctg tgcgatgtgt ggaaaaaagg ttttggatac caaaaactac      420

aagcaaacat ctgtctagat gtattgatgg aatttctggc tttctaaatg attttacttt      480

ctgccttgaa ttttcaaggc atagatgtca acttacagaa taacatgttt taagataatt      540

aagtttaaac cagagaattt gattgttact cattttgctc tcatgttcta aacagcaaca      600

gtgtaactag tcttttgttg taaatggtta ttttccttat aagaatttta agaactaagt      660

ggcaaattcc atgaaaatat ttctcagttc tgtatgcact tttatttaac attattcata      720

taattctccc cccaccactt tatttataga tactgcaaaa gtgagaagga gataatagat      780

actttgctct gaatttggca tccagagtta acatttctcc cctcactccc ttgctggtgt      840

catagttatt agaatcagca gcctcttaac taattgcggt ttcataggat atataaatgt      900

ttcaagccat tattgctgaa tggttcttta gttattaacc tagacccaaa tcaaagacca      960

gttggattta tgatattttt tatttgttct tgcagccaaa gtgccagttt ctttaatatg     1020

tgaccaagaa cacaaggagc atccatatgg ccaaataaat acactgaatt ttagaaaaac     1080

atattacttt gaattcaaat tgtcatgaaa accagaacag tgtttgtcca tgttgcatgt     1140

aatgaaaata aatccctgct ctgagaaaag ctctttgaag caaaaaccaa actttttttt     1200

tttttttttt acctcctgtc ttgcccccta aaagaaataa atagagcaaa catcttgact     1260

ctcccttttt aaaatttgtt tgtttttttt tttttttttt ggatacaaga gctcactctg     1320

ttgcccaggg tggagtgcag aggtatcatc aggctctctg cagcctccat ctgctgggct     1380

caagcaattc ttccccctca gcctcctaag tagctgggga ctacaggcgt gtgccactgt     1440

gctcagctag tttttatttt tagtagagat gaggactcac tatgttgccc aagctgttct     1500

cgaacttctg atctcaagca atcctctggc ctcagccttc cgaagtgctg ggatacaggt     1560

gtgagccaca gaacttggcc tctctctttt tttttttttt tttttttttt ttttaacact     1620

acaggtttca aatgaatact tttcttatgt tgccttcaga ggttcaggac ttctgctttt     1680

aaaacctgca gcctaccgtg ggaaaccaaa aaagcattcc ctatttccaa ctgcagtatg     1740

tataaataca tatcactaca aaatgtatag aaagtgtgat gagatacatg aatggcattt     1800

ttattggtca taacattttg atgaaaagca tttaaagttt taactttata aggcttttca     1860

aaatgtgttt ttctgagata cattgttatt tattcatatc cagaaaaatt acaaggataa     1920

tacagaatat aataaataat ttatctgaga gca                                  1953


<210> 258
<211> 2371
<212> DNA
<213> Homo sapiens

<400> 258
aacttcttcg cgattgcacg gattcaggga cgctcagtgg cgccgcgccg ctccttggtt       60

tgacttttgt ttttcagttg cgttccctga ctcggagtct tagtgtgtcg ttatttggac      120

aagaggcaca ttgacccaat ttggagacgt attttggaag gaggtgtgaa aaagacagca      180

tgaactttac cccaacacac acccctgtct gcagaaagcg aacagttgtc tccaaacgtg      240

gtgttgccgt cagtggtccc accaagagga ggggaatggc agattcactg gagtcaaccc      300

ccttgccttc ccccgaagat cgtctggcca aactccatcc ttctaaggag ctcctggaat      360

attatcaaaa gaagatggct gagtgtgagg cagaaaatga ggacttgctg aagaaactgg      420

aactctacaa agaagcttgt gaaggacagc ataaacttga atgtgatttg cagcagaggg      480

aggaagagat tgctgaattg cagaaagctc taagtgatat gcaggtctgc ctcttccagg      540

aacgggaaca tgttttacgc ctctactcag aaaatgaccg actgagaatc agggagctag      600

aagacaagaa aaagattcag aatctcttgg ctcttgtggg aacagatgct ggagaagtga      660

cctatttttg taaggagcct cctcacaaag tcaccattct ccaaaagact atccaggctg      720

taggtgaatg tgagcagagt gaatcttcag ctttcaaagc agatcctaaa ataagcaaaa      780

gaagaccatc gagagagaga aaagaaagtt ctgagcatta ccaaagagac atacagacac      840

tcatcctaca ggtggaagca ctgcaggctc agctgggaga gcagaccaaa ctttctcgag      900

aacaaattga agggctcatc gaggacagac ggattcacct tgaggaaata caagttcagc      960

accagagaaa tcagaacaaa atcaaagagc taaccaaaaa tcttcaccac acccaagaac     1020

tgctctatga gagcaccaaa gattttctgc aactcagatc tgaaaaccaa aataaagaga     1080

agtcatggat gcttgaaaaa gataatttga tgtcaaagat taagcaatat agggtgcagt     1140

gtaagaagaa agaagataaa attggaaaag tgttgcccgt tatgcatgag agtcaccatg     1200

ctcaaagtga atatattaag tccctaaaag ataagttagt acaagagaaa aagctgtcca     1260

atatgtacca agagcagtgc atttccttag aagaagaact tgcccgaatt cgtgaggaag     1320

agggaatgag gagagagatc ttcaaggatc gcactaacaa gatggggaag cgtttacaga     1380

taatgacaaa acgctatgag gcattggagc gtcgacgtat cctggaagta gaaggcttta     1440

agacagatat taaagttctc cgacagaaac tgaaagactt ggagcaaatg ttgtataagg     1500

caacagttaa tgcccgggca aaccaggatc ttgcccttct gtgtgaggtc cgtgacagca     1560

atagacgggc acataagata caaggagaac tgaagaatct taagtcgaaa gtgtttggtc     1620

tggagaatga acttagactc tgttaatgtc tacttttgga aatggccccc atttagaaga     1680

ggtgtgcttc ttgaaacctg aggacaaggt catctgctgc cagaaaatgt aaacctgagt     1740

tgactagagt ggtggtattc attattgtaa agacagcttg aagaatcggg gaccactagg     1800

aaagcttttc ttgcatactc agcttgcttt atcatttttg ctgtcctttt aacacttgcg     1860

aggagtaggg gcctggtcct gaatgacttg gaggctttca ttatttatcc tgtctgtatt     1920

gaccggtttt tgttttttca gaaggcagtg atgatgaaaa cttaggaaga aggtattttg     1980

caataagctt ggctgagtgt ccatgggaag aatactttcc ctaaagagag agaagcactc     2040

acagaggctg cctttctcct gagctcgggg agaaggcagc acatcacaac ctgtcacatt     2100

gaaataggcg ctcattctgc tatttcacct tccgtcctga gcagagcctg aattacgttt     2160

ttgggcaatt tcatggtgtt tcaccagagg gcgctagaga ctcaaacgaa atgtccatct     2220

ggaaagattc gggagacact ttgccgaggg gatgaagctg agatgatgct tgtatggaaa     2280

gtttgatatt tttatcagtc acatggcttt tgaaaaatga tgtatatatt ttaaattaac     2340

tattttcaat aaaatatttc actcaaaaga t                                    2371


<210> 259
<211> 2522
<212> DNA
<213> Homo sapiens

<400> 259
cggagttgtc gtgtgttctg gattcattcc ggcaccacca tgtcgaaggt ttcctttaag       60

atcacgctga cgtcggaccc acggctgccg tacaaagtac tcagtgttcc tgaaagtaca      120

cctttcacag cagtcttaaa gtttgcagca gaagaattta aagttcctgc tgcaacaagt      180

gcaattatta ccaatgatgg aataggaata aatcctgcac agactgctgg aaatgttttt      240

ctaaaacatg gttcagaact gcggattatt cctagagatc gtgttggaag ttgttaatat      300

ctgctacttg gaacatacga ttgcctttca gaataaatat tggtattttt tgttgttgta      360

aaattgaaat caggcattta acatactatg aaaacaccag gagtcaatga ttaatgaaag      420

gtgactcatc tgtccctttt tgttgtccat actcttccta tgaagaggga atgcgtatga      480

attaaggcta ctactgtcac agaagatcat agtctttgat gctacctcac aacacaaaca      540

ggtagttcgt tgggggcaaa tgaattagcc aactgttaac tggaagcttt tgataatttt      600

tttttttaga acaatttgga acattaaaat ttactgaatc gtatatattc atctgagata      660

aaaatataaa aagaattatg gaccctggat ggcaatttgc ttgatagcat ctgatttgca      720

gactcataat ttgattttta attaaatata taggttgtga tgaagtgaat agacatatca      780

gtgaacagtt aactatatta aatttttatc atttactttt tttaagattc agacctcagt      840

tatataaatt tcagtttaat atcaaccaaa aaattaaaat tttaatctaa cccttatgtg      900

tataaattgg tgtcccatac cagcttttaa tggtggacct atagaatcca gtacttttaa      960

tggtgggaat ttacagtaga agcatccttt gctgagttat acattccttt atcaatctct     1020

tttgatacaa catttaaaac aagtagcttc aagaaaccac tggtgttttg aggatagtat     1080

ttctaaatag cattcaggaa cagagtatta ttgcacagat ctgaagatca aaaaaaagct     1140

caaggaaata cagatcggaa gtgctgatga gttatattta ttgaaaaccc aacttttaag     1200

gaagtgctaa gatcagtcac ccatgtgaat aagaagccag gaaaggaaag atggggaagc     1260

ccagatcacc aggcttctat taaggaggaa agcaacagag gaaacagtga aggggaacag     1320

aagggggtag caaagtgtta cagaaaagcg gactggatag acaaaactgc agaaggtgta     1380

tgttggggag aactgaaagg gaaaacaaaa tacttgacat agtcttaagt agaagaaggc     1440

agttagagaa aacaaagtat ctactggcct tgtcaacata cagacttcaa aatacccctt     1500

atgagaatcc aaagaatgat gtgtgtaagg gaagatttta tttgcccttc cggaagaaat     1560

cagtatctat gcaaatcttg aaagacgaaa tcaaagccca ttaatgattc agaatcagtg     1620

cttgacctcc tgtattctga atggtgaact ctggaagcag ggattgtgtc tggctctttt     1680

tagagctgga aatgtagtgg ctttcattaa atacttgctg taaagtcttt ctaagaccaa     1740

ttattatctt agcatgtttc agtatcttct ctatcatagg ccctaagttc attgggggaa     1800

aaaaaataag aagattcaac agaatcagca tttgaagtgt accattggta gttgtttatg     1860

aaattaccag atattcataa atgtgacaaa tgaacagcag gattatgaat tatcaaagga     1920

aaaagtattt gctgaggtga aaaaatctga tgtttgagga agtttttatt tttatttatt     1980

tgttttgttt tttttttttt gaggcagact ctctgtcgcc aggcttctcc tgcctcagcc     2040

tcacgagtag ctgggactac aggcatgcac caccacgccc agctaatttt tgtattttta     2100

gcagagacag ggaggaagtt tttattttta taaacaaaat ctgatgttca gaggccccgt     2160

ttcttacaat aaatgttgag tcttagttaa gcaggaattt atgaacaccc atttcctgac     2220

tttttgcttt aatttagatt tttctccatc ctgtttctag cacaaaaatt tgcctgctgt     2280

gttacaaaaa taaatttatg ttgtcctgtg ccataaagtg atatatttaa tatttttatt     2340

ctttggtttt gaacattgta agttcctaaa aacattttat taaacaagta gacattttgt     2400

tattaaaaaa atgtgatctg taatttcttt gtgcagaatg atttgaagta ttgtattcag     2460

tttacatgcg ttattggttt ataattaata tctaatgaaa atacatgttg ttatattgta     2520

aa                                                                    2522


<210> 260
<211> 916
<212> DNA
<213> Homo sapiens

<400> 260
ggaagccgcc gagtgattag tgagcggaga agctttcttc cggcgggaag ggccccggag       60

gcgggcactt ggggggaaag ttgagacgtg attaccgggt tgggcgggcc ccatctggga      120

ggggtttgtg ggtgaactcg gggtccaccg cccgctgagg agatggatga ggacgggctt      180

cctctcatgg ggtcaggcat agacctgacc aaggtgccag ctattcaaca gaaaagaacg      240

gtggcttttc taaaccaatt tgtggtgcac actgtacagt tcctcaaccg cttttctaca      300

gtttgtgagg agaaactggc agacctttca cttcgtatcc aacaaattga aacaactctc      360

aatattttag atgcaaagtt gtcatctatc ccaggcctag atgatgtcac agttgaagta      420

tctcctttaa atgtcaccag tgtcacaaat ggagcacatc ctgaagccac ttcagagcaa      480

ccacagcaga acagtacaca agactctgga ctacaggaaa gtgaagtatc agcagaaaat      540

atcttaactg tagccaagga tccaagatat gccagatatc tcaaaatggt tcaagtgggt      600

gtaccagtga tggcaataag aaacaaaatg atatcagaag gactagaccc agatcttctt      660

gagaggccag atgctccagt gcctgatggc gaaagtgaga aaactgtaga agaaagttca      720

gatagcgaat cttcttttag tgattaagct taattttgat aagaattaca tatgcatgca      780

taggggtaca tttacattct gtaagagatt gagcctgaac tctcttagtc ataaaaacat      840

caaatggcca catgtccact accaagcttc ttctatgtta aaaaaataat aataaagcag      900

ttttaacctg ccagta                                                      916


<210> 261
<211> 2763
<212> DNA
<213> Homo sapiens

<400> 261
gacgcgcgcg atttaaaacc agctcaggag acgccaagga aagatgggac ctcccggccc       60

agcactgcca gccacaatga ataactcttc ttcagagacg cgaggacacc cccacagtgc      120

ctcctctcct tcagagcgtg tgttcccgat gcccctgccc aggaaggcgc ctctcaatat      180

tcctggcacc ccagtcctcg aagactttcc tcagaatgac gatgagaagg agcggctgca      240

gcggaggcgc tcgagggtct ttgatctgca gttcagcact gactcacctc gcttattggc      300

ctccccctcc agcaggagta ttgacatttc agctactatc cccaagttta caaacacgca      360

gattacggaa cattactcca cctgtatcaa actgtccact gaaaataaaa tcactaccaa      420

gaatgctttt ggtttgcact tgattgattt tatgtcagag attcttaaac agaaagacac      480

cgaaccaacc aactttaaag tggctgcggg tactctggat gccagcacca agatctatgc      540

tgtgcgcgtg gatgccgtcc atgccgatgt atacagagtc cttggggggc tgggcaaaga      600

tgcaccgtct ttggaagaag tagaaggcca tgttgctgat ggaagtgcta ctgaaatggg      660

aacaaccaaa aaggctgtaa agccaaagaa gaagcactta cacagaacta ttgagcagaa      720

cataaacaac ctcaatgtct ccgaagcaga tcggaagtgt gagattgatc ccatgtttca      780

gaagacagca gcctcatttg atgagtgcag cacagcaggg gtgtttctgt ccactctcca      840

ctgccaggac tacagaagtg aactgctgtt tccctctgat gtccagactc tctccacggg      900

agaacctctc gagttgccag agttaggttg tgtagaaatg acagatttaa aagcgccctt      960

gcagcagtgt gcagaagatc gccagatctg cccttccctg gccgggttcc agtttacaca     1020

gtgggacagt gaaacacata atgagtctgt gtcggccctg gtagacaagt ttaagaagaa     1080

tgaccaggta tttgacatca atgctgaagt tgacgagagt gactgtggag acttccccga     1140

tgggtccctg ggggatgact ttgatgccaa cgatgaacct gaccacaccg cagttgggga     1200

tcatgaagag ttcaggagct ggaaggagcc ctgccaggtt cagagctgcc aggaagaaat     1260

gatttccctt ggggatggag acatcaggac catgtgcccc cttctgtcta tgaaacctgg     1320

agaatattct tatttcagtc ctcggaccat gtcgatgtgg gctggcccgg atcactggcg     1380

ctttaggcct cgacgcaaac aagatgctcc ttcccaatca gaaaacaaaa agaagagtac     1440

aaaaaaagat tttgaaattg actttgaaga tgatattgac tttgatgtat attttagaaa     1500

aacaaaggct gctactattc tgaccaagtc cactttggag aaccagaatt ggagagctac     1560

cacccttcct acagatttca actacaatgt tgacactctg gtccagcttc acctcaaacc     1620

aggcaccagg ttacttaaga tggcccaggg ccatagggta gagactgagc attatgaaga     1680

aattgaagac tatgattaca acaaccctaa cgacacctcc aacttttgcc ctggattaca     1740

ggctgctgac agtgatgatg aagatttgga tgacttattt gtgggacctg ttgggaactc     1800

tgacctctca ccttatcctt gccatccacc taagacagca caacagaatg gtgacactcc     1860

agaagcccaa ggattagaca tcacaacata tggggagtca aacttggtag ctgagcctca     1920

gaaggtaaat aaaattgaaa ttcactatgc caagactgcc aaaaagatgg acatgaagaa     1980

actgaagcag agcatgtgga gtctgctgac agcgctctcc ggaaaggagg cagatgcaga     2040

ggcaaaccac agggaagctg gaaaagaagc ggccctggca gaagtggctg acgagaagat     2100

gcttagcggg ctcacgaagg acctgcagag gagcctgccc cctgtcatgg ctcagaacct     2160

ctccatacct ctggcttttg cctgtctcct acatttagcc aatgaaaaga atctaaaact     2220

ggaaggaaca gaggacctct ctgatgttct tgtgaggcaa ggagattgag ttcactatgg     2280

agaagtcagc agcaggaggc ccatccctta ctcagttgcc gggacatccc cagtctcggg     2340

ggaagaagat gccatgggct tatacccagg ctgtagccaa ctaccaacgt gcctgtttgt     2400

ttgttgctct ttccttctct ccatcatagt ctgggtgcca gcgccctgaa gctccgtgct     2460

caactgatta aactttactg ccctatggtg accatctagg agaggggagg gcagaggggg     2520

tgagggtact attctggatt gagaaaacct atatccattc tttatatcaa tgtatagttt     2580

tagtctccta aattgatctg ttattttcca aactattctc ttgtagaaaa ttttccagtg     2640

ggcacttaat ggtgcccttg aagaacttcc taatccatgt acataaaata catcatatgt     2700

acacttataa atgtatatag aatgctcaaa aataaaattc ttaataatag aactggcaaa     2760

ata                                                                   2763


<210> 262
<211> 3601
<212> DNA
<213> Homo sapiens

<400> 262
cgcgccggcg cgcgaggggc ggggtgaaag gtcacagcgc ggcagcgggt ctggctggcg       60

gcagcggcgg gagggagccg agagacccga gtgcacgtgt ggagaagcgg cggcacaagc      120

gcggcggcgg gagacactcc cgcccccacc agactcaagc cctcactcga ctctcgcggc      180

cttcgttgct cgcacagctc cctgcccagg ctaggaggcc ggcttgcggg gttgagtggc      240

ccgagctaag ggtgcggaga cctaagggcg gcgactacga cggcgttgat atcggtggta      300

acgacggcct cagcaggcgg ggaagatgaa aggtagccgg atcgagctgg gagatgtgac      360

accacacaat attaaacagt tgaaaagatt gaatcaggtc atctttccag tcagctacaa      420

tgacaagttc tacaaggatg tgctggaggt tggcgagcta gcaaaacttg cctatttcaa      480

tgatattgct gtaggtgcag tatgctgtag ggtggatcat tcacagaatc agaagagact      540

ttacatcatg acactaggat gtctggcacc ttaccgaagg ctaggaatag gaactaaaat      600

gttaaatcat gtcttaaaca tctgtgaaaa agatggtact tttgacaaca tttatctgca      660

tgtccagatc agcaatgagt cggcaattga cttctacagg aagtttggct ttgagattat      720

tgagacaaag aagaactact ataagaggat agagcccgca gatgctcatg tgctgcagaa      780

aaacctcaaa gttccttctg gtcagaatgc agatgtgcaa aagacagaca actgaacaaa      840

ttacaaatga actttcttgc acttgcttgt cgccaaataa aagagaggcc cattgattcc      900

tcccccaccc caacactttt cttttaaagc ttttctccct ccttgttctt gtttttcttt      960

cttcctttcc ttttctctga gagttttaat actttcaagg actttaaaaa aataatcatg     1020

tttgaattgt tttctcttat ttttgtgagg tggtttgaag gaaggacaag gtagatctgt     1080

ttagttttgc agttgaagtt agatggtcct aaacatttaa ttgtcaaata atttcaaatt     1140

taatgtcctg ctttcacatt gaagggcaga gcctacaaaa cattgtatat ttcaaaagac     1200

aaaaagaagc agcagcagta tcttgttctc taattcatag acaagttgag tgtgtttgtg     1260

gtactttggg tttttaaaca ctttgggata ctaatcccta gacattgcct tcactccacc     1320

tttagtcctt ctgagcactc tctcgggagt tggaacattg ttatccttgt aagaaatact     1380

aagcttatgt tgatttttaa gtaattatat cttctcttct tgctggtggg tggggcagtt     1440

tggtttagtg ttatactttg gtctaagtat ttgagttaaa ctgctttttt gctaatgagt     1500

gggctggttg ttagcaggtt tgtttttcct gctgttgatt gttactagtg gcattaactt     1560

ttagaatttg ggctggtgag attaattttt tttaatatcc cagctagaga tatggccttt     1620

aactgaccta aagaggtgtg ttgtgattta attttttccc gttccttttt cttcagtaaa     1680

cccaacaata gtctaacctt aaaaattgag ttgatgtcct tataggtcac tacccctaaa     1740

taaacctgaa gcaggtgttt tctcttggac atactaaaaa atacctaaaa ggaagcttag     1800

atgggctgtg acacaaaaaa ttcaattact gtcatctaat gccagctgtt aaaagtgtgg     1860

ccactgagca tttgatttta taggaaaaaa tagtattttt gagaataaca tagctgtgct     1920

attgcacatc tgttggagga catcccagat ttgcttatac tcagtgcctg tgatattgag     1980

tttaaggatt tgaggcaggg gtaattatta aacatattgc ttctattctt ggaaaaatag     2040

aagtgtaaaa tgttaataat acaaatgtca ctgtgacctc ctccactgag aggactggtt     2100

tatgccagat cattttccgg cacacacgga gtggctttga cagattgata actttgtaag     2160

atgggagaca tctgaaatat tcatgttttc cttttgtagt cccatctcca ctatttagaa     2220

atgttctcag actttaaaat aatgcacagg gcttgagctt tctgtcattt gactttaaaa     2280

ggaagtttca ttcatattta tcctcttatg taaaattgcg gtataaagtc tcatttccaa     2340

atatgttaaa tgacaaaatt attttataaa atgtttatgc acactttata accttaagtt     2400

tttatttgag aatgtgaaag tacaaagtgc agtagacttc aacaatcttg agtgccaaga     2460

ataatacaga aaaagaagac agttgatgaa tgagtttata gggttctaat cttaagatgg     2520

taaaaatgta gaaagacctt gctggttttt tgggggtatt cgtttcttaa acaatccaaa     2580

tctaagctta gaagaaaagt ttagcgttaa gcacctttat cttcatgaat aagcttcagc     2640

ttgctcttgg caagagaaga gtgcttgagt tacagaaggc ataagtagtt tgaagaatgc     2700

agcagccttt ttgtaaactt cccagatatc aaaatagact ttgatatata aatggttttc     2760

tgagatgaca ctgcctctat ttctataacc atttcacctg gactatctaa tcagtcctat     2820

gaatgtatcc ctaaatgtgg ttattgaaaa cctaatagct gcctcatgac aagtacatgt     2880

tatttaagga ggaaaaaata ttaaattttg aattgagtgt gtaggctccc tatcattata     2940

tatagagttt ctttttccac ggtagtcagt gacttaacct gaattgtaaa tgtttgtaaa     3000

gggttaattg tcctacatca aacttagtta aataattcca tccacttatg gaggaggagg     3060

agaatgtgga agaggtaaaa agctgggcac aagttcatat gcctatgagt cagtaaagac     3120

tgaagtaatg tcctatgttg agctggttat tttgatatat gataataatt atctttgaag     3180

tagaacaatt ctgttaactg gaaaatcaca ggatatatcc atcatatttt tcaggacaga     3240

tagtttttac tgtggggcaa ataggttaaa attacactat gttagttgca tttaggtttt     3300

aaagcaaaga atctgtagag aaatctatgc aatatatagt ttgtccagat tagctttcat     3360

ttggggaatg aagttctgaa atatctaaag cagtttactc atcaattgaa aagtcctcca     3420

aaaagagaac tattgggaaa ccatggtgtg gtggtggaaa agaaaagctc cctcagtttt     3480

ttggagggaa taacttaaaa aaatacttaa atggctaagt ttacttggtg cagttaagaa     3540

ttaaacttgt caattttaac attgctgtta catctgaaat aaacttatgt gatgttctgg     3600

t                                                                     3601


<210> 263
<211> 5257
<212> DNA
<213> Homo sapiens

<400> 263
tctgggtagg gggaagcgcc cggcggccgc ctccgccact gcagctgcag cccccgaggt       60

cgccgcagta atccggaccc ggcagcaccc gcaccctcgg cggccgcagc ctcagcaccg      120

cagagcggag agcggagccc ggagcccgcc gccccaggat ggctgcagct cctccaagtt      180

actgttttgt tgccttccct ccacgtgcta aggatggtct ggtggtattt gggaaaaatt      240

cagcccggcc cagagatgaa gtgcaagagg ttgtgtattt ctcggctgct gatcacgaac      300

cggagagcaa ggttgagtgc acttacattt caatcgacca agttccaagg acctatgcca      360

taatgataag cagacccgcc tggctctggg gagcagaaat gggagccaat gaacatggag      420

tgtgcatagc caatgaagcc atcaacacca gagagccagc tgccgagata gaagccttgc      480

tggggatgga tctggtcagg cttggtttag aaagagggga aacagctaaa gaagccttag      540

atgtcattgt ctccttgttg gaagaacatg gacaaggtgg gaattacttt gaagatgcaa      600

actcctgcca cagcttccaa agtgcatatc tgattgtgga tcgtgatgaa gcctgggtgc      660

tcgagaccat agggaagtac tgggctgccg agaaagtcac agagggagtg aggtgcattt      720

gcagtcagct ttcgctcacc actaagatgg atgcagagca tccggaactc aggagttacg      780

ctcagagcca aggttggtgg acgggagagg gcgagttcaa tttttccgaa gtcttttctc      840

cagttgagga tcatctagac tgcggtgctg gcaaagacag cttagaaaaa caagaagaaa      900

gcatcacagt gcagactatg atgaacacct tacgggacaa agccagcgga gtgtgcatag      960

actctgagtt tttcctcacc acagccagtg gagtgtctgt cctgccgcag aatagaagct     1020

ctccgtgcat tcactacttc actggaaccc ctgatccttc caggtccata ttcaagcctt     1080

tcatctttgt tgatgacgta aaacttgtcc ccaaaacaca gtctccctgt tttggggatg     1140

acgaccctgc caaaaaggag cctcggttcc aggagaaacc agaccgccgg catgagctgt     1200

acaaagccca cgagtgggca cgtgccatca tcgaaagtga ccaggagcaa ggtcgcaagc     1260

tgaggagcac catgctggag ctggagaagc aaggcctgga agccatggaa gaaatcctga     1320

ccagctccga gccactggac cctgcggaag tgggggacct tttctatgac tgtgttgaca     1380

cggagattaa gttctttaag tgaagtaagc gttccctttc cccttcttat ttaagacttc     1440

ccaccttact aaattaccag caaaacaaac cactctcctg tttgagtaaa atgagaaagt     1500

taatatgtgg cctccttttc tgaagccaga tcaaactgtt accttgtgtt ccaccttgaa     1560

tctcacagcg tccccttctg caatgtaggt ctccttcctg tgcagtgtaa catgtatccc     1620

gttgcctgtt gttcggttgt gtgactaatt gtggatttta agctgctatt attgtatttc     1680

agtggcaatg gacacattag ccttttacaa gaggactaga gttcatcaag ccttgaaagg     1740

caggcttcac agtgccgagt tggcgggaaa agcaaattct tttgaagtct tagtctttcc     1800

ctcagtagcg gtttctttca ggttaacaag aggcatttgt gcacacacac agggctcttg     1860

tgtgtgttgt caaggggacc ctccgtggcc tcccgtgagt gcatgcctgt agtgcacagt     1920

gtctctacag gtgtcttctg gggggcagaa ccaattggaa ggaagaaagg gacccctctc     1980

cagtcctggc tccttcctac atcctgggct cctgaagaag ctgtcttccc attttccatg     2040

cgctgtgctt atgtgtggtg gactgcagag ctgcttccac ttacaggaga gctgataatt     2100

tgttagctgg aacctattca cttccgagat tcagacatag ccatgctggt ggccttctga     2160

atcactgcat ggatgtccca ggaggcagct ctccccacac agcagcacag ccatcacagg     2220

attccttgtg tagaaatgat tcccagtcta gttaccaaca gctagtctag gagtaattga     2280

atggccctat ggcacagttc cacccacaga gtagtgaatc tctcagccaa ggagggaaag     2340

aaaaggaaga actcttgact atttagattc tagttaaata tctggaatcc tagcagtcac     2400

tacattatct cagcagagag actttaatta aactgatttg tttccaatgt cgggttcact     2460

taaaggattt gacttaccac cagagcatag aaaagcatgc aaggaagacc agatgggctt     2520

agcattggga agacagaggg caaggaggtg atagatggat atagaagcat ttctctgcag     2580

gataccagtt caggccccac cattcctgcc aaggccatta catcccacaa acccaaatac     2640

aaagcagctg acttccctgg atcttccccc cactcctcac acctcacatg tcccaggagc     2700

tgccttcatt caggcgggta gctgcactgg gcatggggtg gtggtgggag cttaccgcca     2760

cctattcaag ctctcagcta ctcctgaaac gggcagagat gatgaacaga agtgtatgta     2820

aatacagcag ctagtgggag agcaccagtt gggcctaatc ctgcctcatc attcttggca     2880

ggaatctgca aatggaaaca ttgtgagtat cagcaatctg ggaagtgaca gggttaataa     2940

ctccttccca gaagctgtat catgagattt tgaggggacc gagccctgtt acatggatgt     3000

gaacagtgag gatcagaggt tttatcagaa cacattcttt ttttctacca actctccaga     3060

gcgtgagtat aggagtgcca tgagcttttt agtcagcagt tttgtaaact ctgtatataa     3120

aatcattaac cacacattgt gggtgatggg aagacgattt cagctgacag agttaatggc     3180

aaccaataat ggtggcctgt agctgctaag agcttcacgc aggtttggcc tgggctttca     3240

ctgttggtga atttagagtg tccttttagg tggggcggct attctaaaag tgtctttcta     3300

tcactgttaa ggggggggga aagtgaggtt cgaggatgac gtaggtaact ctcccctccc     3360

aagtccatgt tccaagtggc tatgtaaagc aagatgatac agaaagctgc tctaaaatct     3420

cactgagtga tttcaccttc gcctactatg aaatgtctca tcagacctga catgtctgag     3480

ataaccaagg tgattcagga tttgatcaaa agaagtctag taagaattaa ttacacagaa     3540

gcctcctttc atttctatgg gccaaacaaa ggccatggat aaccctaccc gctttatgtc     3600

attacccatt gggaaacaca atggctactt ctgttagggt acattgacct tggtcaagca     3660

tcttaaagaa ggcaacccta attgagagct gtcttggcta atactctgca ccacaattgt     3720

gatgtcctag tcctaccact agagggcatg gtacagcctg gcaaaagtta aaaggggtgt     3780

ggcagctccc atcaggtctg gaggtggtct ataagcacag ttgacagttg tgcattggga     3840

tgggtggaga aagacgacaa gagagcagag aatctgctga tgtggctgcg cttactttta     3900

gtgactttat gtacttatat taacagctgg aaataggttg ttgggttttg agcaggctgt     3960

tatagtgagg aatgttcatt tttaaatgtt cctaacagat tttgcttttg aaaaatgctt     4020

gttacatgaa taatttgtgg accagggatt gcttttctga aggcagtata gggaacatga     4080

atattcaaga tgaaatacaa aaattatgtt taagggtcat agtgtataag tagcttccta     4140

ggaaaccctt tgtgtatctt ttcagactgg ggtgggggct gagcatgctt gtgcagaaag     4200

aagccatagc cagaaaggac agaatctctc ccccactccc ttgccccata accaaacata     4260

agctagctag tcttgtctaa tagatgggat ttactatagg tgaagatagc cctcatattc     4320

aaggacagaa gctctggcag gagtaaatta gcaaagcaga aatagtaccc tttcattctt     4380

ggaggtgctt tgaaatttta ggtagaatat aatcgaaatt atggaggttc cttagtgctc     4440

aataatataa gacctggtgt tattagaacg agtctttctt ataaactaac agagcaggta     4500

tatgcctgtt agaccttagc tgtggggttc ctttactatt gggtgaatca ttaggtataa     4560

aaaataatca tcaaccaggc aaattacttt gcttcctagc tgatgtcatc ccacattggt     4620

acaggtgtta ttcagtactg ggtggttcag cagggaagcc gggtgggacc agtgtgtctg     4680

tcatgaaacc actaactgca ttcctgactg aagagccatc tgtcatttat tggggaaggt     4740

cttcagttga gctctcagcc ttaggaagga agcacgtgga ggagggacgg aggaggttcc     4800

cttgctgggc atgcttcgta gagggccagg agcagcaggt catgtgcaca tgccgttgca     4860

gcacaagctt atgcttcccg tagccgtggc ttttcattct gcacagtccc aggtcccagc     4920

tcccctctta tggtttctgt cataatgtgc tttatctgat tgactccaaa catcccgaaa     4980

tgtcacctgc agatttctcg tgggaaccaa tatgtacatg tttgcaatta tgctgtgaga     5040

atttaaatgt gttagatgga aaatgctatt ggcagggaat aataataaaa aaaaaagaaa     5100

atcattctgt ttcctgcagt gggaactggc catgtagtct taacagtctt ttgtacaaat     5160

atctacaaag cagataatat ccctatccag tgcttgccct tggaattgtc tctaaatgca     5220

tcaagcatac aataaaaaaa actgaaatta acatcca                              5257


<210> 264
<211> 3108
<212> DNA
<213> Homo sapiens

<400> 264
tgggagcggt ctagagcccg ggcgcctcct ggggggtggg gaaacggttt cgtgaggaga       60

atttgaggta acctcgccaa ctcgcggtcg gaagctcctc tgaaccccga aataggagag      120

agctcccgtc ctctctcggt cctgatgcag cacctcgcaa gtggaagggg tcgtcgcggt      180

taagcccccg gataggggaa tcgggcccct tctgggattc gagcggatcc aggccgctcc      240

ctggagggat gaactgtcga ggggcccagg gcagcccccg ctagaggccc ggtcgggtgt      300

ggggtcccct gtcccctgtc ccgagcccgg ggagggggac actatttctg gtactcccag      360

gaggctgcgg gtcgatgctc gtgccagcct gggacccagg cagcacggtt tctctcccaa      420

attgtgccag agaacacgca cgtcctggtt ttcattgttc cccgcctcct gcgactcgtt      480

tgtggttaaa attataagac ctaattatga gtgatcaaat taaattcatt atggacagtc      540

tcaataagga gccctttagg aagaactata atttaatcac gtttgattcc ttggagccaa      600

tgcaactatt acaagttctc agtgatgttc tggctgagat tgacccaaag caacttgtgg      660

atatcagaga ggagatgcca gagcagacag ccaaacgaat gttgagcctt cttggtattc      720

ttaagtacaa accttcagga aatgccacag atatgagtac ttttcgtcag ggtttggtga      780

ttggaagtaa acctgtaatt tacccagtgc tccactggct tcttcagagg actaatgaac      840

tgaagaaaag agcatattta gctcgttttt taataaaact tgaggtacca agtgagtttc      900

ttcaggatga aactgtggct gacaccaata aacagtatga agagttaatg gaagccttta      960

aaactttgca taaagaatat gagcagctca agatatctgg attttctaca gcagaaataa     1020

gaaaggatat cagtgcaatg gaagaagaaa aggatcagct cattaagaga gttgaacatt     1080

tgaagaaaag ggttgagaca gctcagaatc atcaatggat gcttaaaata gcaaggcaac     1140

ttcgagttga aaaagagaga gaagaatatc ttgcacaaca gaaacaggaa caaaagaatc     1200

agctatttca tgcagtgcaa agattgcaaa gagtacaaaa ccagctgaaa agcatgcgcc     1260

aagctgcagc agatgcaaag cctgaaagtt taatgaagag gctagaggag gagataaaat     1320

ttaatttata tatggtaact gaaaaatttc ctaaagaatt agaaaataag aaaaaggaat     1380

tacatttttt acaaaaagta gtttcagagc cagctatggg ccattctgat cttcttgaac     1440

ttgaatctaa aataaatgaa ataaacacag aaattaacca gttgattgaa aagaaaatga     1500

tgagaaatga gcccattgaa ggcaaactct cactgtatag gcaacaggca tctatcattt     1560

cccgtaaaaa agaagccaaa gctgaggaac ttcaggaggc caaggagaag ttagccagcc     1620

tagagagaga agcatcagta aagagaaatc agacccgtga atttgatggt actgaagttt     1680

taaagggaga tgagttcaaa cgatatgtca ataaacttcg aagcaagagt acagttttca     1740

aaaagaagca tcagataata gctgaactta aagctgaatt cggtcttttg cagaggactg     1800

aagaacttct taagcaacgt catgaaaata ttcaacaaca actgcaaact atggaggaga     1860

aaaagggtat atctggatat agttacaccc aagaagagct agaaagagta tctgcactga     1920

agagtgaagt tgatgaaatg aaaggacgaa cattggatga tatgtctgaa atggtgaaaa     1980

aactgtattc attggtatct gaaaagaagt cagctcttgc ctcagttata aaagagctac     2040

gacagttgcg tcaaaaatat caagaactga cccaggagtg tgatgaaaag aaatcccagt     2100

atgatagctg tgcagcaggc ctcgaaagca atcggtccaa attagaacag gaagttagaa     2160

gactccgtga agaatgtctt caagaagaaa gtagatacca ttatacaaat tgtatgatta     2220

agaacctaga agttcaactt cgtcgtgcta ctgatgagat gaaggcatat atctcttctg     2280

atcaacaaga aaaaagaaag gcaattaggg aacagtatac caaaaatact gctgaacaag     2340

aaaaccttgg aaagaaactt cgggaaaaac aaaaagttat acgagaaagt catggtccaa     2400

atatgaaaca agcaaaaatg tggcgtgatt tggaacaatt aatggaatgt aagaaacagt     2460

gctttctgaa acaacaaagc caaacttcca ttggtcaggt aattcaggag ggtggggagg     2520

accggctaat actgtgaatt cttgtgtcat cgtttggggt tttacttgat accactagct     2580

ataagcctaa tctcataatg tatttctttt ttgaaactga tttgtatagc attttgtttt     2640

cagaagagcc attctttatt aagttttcat agaaaataat gttaaggtag atttagtttg     2700

aatgtttttt catatgaaaa agaggctttt attcttttcc atagtttaga catcactggc     2760

gtcttctgag ttttatgaga caggaaacta agtttactat ctgtaaatgt aaacatatgt     2820

ccattaagaa acatgtagtt tttttttaga atgtaataac ccagtggctt actgtttttc     2880

ttaatctctt ttaaaaaaac tttagaagaa tcttttagga actaatatct cttgttctga     2940

agaaacattt atctgacgtt cagcagttcc tacagtttta cttcagttta tttttcttct     3000

gtaaaatgca agaaaattta atattttgac taacatgtct tttctgtttg tatcatttaa     3060

aggcaaataa acttggtacg tatttcatat ctatttaaaa aatgtata                  3108


<210> 265
<211> 1195
<212> DNA
<213> Homo sapiens

<400> 265
aataaggtta cacccaagcg tgggtttcta aggcgcggaa ttttccgtac agaccgattt       60

aaggctgcaa ggaaggagtc ctgggagcat ggctttccct gagccaaagc cgcggcctcc      120

agagctgccg cagaaacggt tgaagacgct ggactgcggg cagggggcag tgcgagccgt      180

acgatttaat gtggatggca attactgcct gacgtgcggc agtgacaaga cgctgaagct      240

gtggaacccg cttcggggga cgctgctgcg gacgtacagc ggccacggct acgaggtgct      300

ggatgcggcc ggctcctttg acaacagtag tctctgctcc ggcggcgggg acaaggcggt      360

ggttctgtgg gatgtggcat cagggcaggt cgtgcgcaaa ttccggggcc acgcagggaa      420

ggtgaacacg gtgcagttta atgaagaggc cacagttatc ctgtccggct ctattgattc      480

cagtatccgc tgttgggatt gccgctcacg gaggcctgag ccagtgcaga cgctggatga      540

ggccagagat ggcgtgtcca gtgtgaaggt gtcagaccac gagatcctgg caggctccgt      600

ggatggccgc gtgagacgct atgacctaag gatggggcag ctcttctcag actacgtggg      660

cagccccatc acctgcacct gcttcagccg ggatgggcag tgcaccctgg tgtccagcct      720

ggactccaca ttgcggctcc tggacaaaga cacaggggag ctgctgggcg agtacaaggg      780

ccataagaac caggaataca agctggactg ctgcctgagc gagcgtgaca cacatgtggt      840

cagctgttct gaggacggga aggtgttctt ctgggacctg gtggagggtg cgctggctct      900

ggccctgcct gtgggttccg gtgtggtgca gtcgctggcc taccacccaa cagagccctg      960

cctgctgacc gccatgggag gcagcgtcca gtgctggcga gaggaggcct atgaggcaga     1020

ggatggagca ggctgaagcc aggggaccca ccaacaggac caaggaccga gacacagaca     1080

tggaaggact tcagatacca tcttattcta gagacgtagc tgaccaaaaa gtaggggagg     1140

ggctgggtct gcaaattaat aaatagaaga gggggtaaga ccttcctggg accgc          1195


<210> 266
<211> 2345
<212> DNA
<213> Homo sapiens

<400> 266
ggccagggtt cgctgacgct cagtgttttg gcccggacgg tcacatgttt cctttgttgt       60

gagctgcggc agagactggt ggctggagga gacgccggcg ctggagagtg cgctgcgccg      120

cccgccgctg agggaccgcg gggttagcca ctgctggctg cttccagtgt tcgccgagag      180

gtaccggggg tgacagctcc gggaccggcc gaaaggcgag gaaccggtgt ggaaattaaa      240

agaacacaca tattttgact ggggctttga tcaaccaaat gctaaaaagc cacataaaga      300

agatccctaa tagtcatttc tcaacaatta tatagtcaac tgatgtaaca atggtactaa      360

tattgggacg cagactaaac agagaggatc ttggggtgcg tgattcccca gcaactaagc      420

gaaaagtttt tgaaatggac cccaaatctc tgacaggtca tgagtttttt gacttctctt      480

caggatcatc ccatgccgaa aacatactcc agatatttaa tgaatttcgt gatagccgct      540

tattcacaga tgttatcatt tgtgtggaag gaaaagaatt tccttgccat agagctgtgc      600

tctcagcctg tagcagctac ttcagagcta tgttttgtaa tgaccacagg gaaagccgag      660

aaatgttggt tgagatcaat ggtattttag ctgaagctat ggaatgtttt ttgcagtatg      720

tttatactgg aaaggtgaag atcactacag agaatgtaca gtatctcttt gagacatcaa      780

gcctctttca gattagtgtt ctccgtgatg catgtgccaa gttcttggag gagcaacttg      840

atccttgtaa ttgcttagga atccagcgct ttgctgatac ccattcactc aaaacactct      900

tcacaaaatg caaaaatttt gcgttacaga cttttgagga tgtatcccag cacgaagaat      960

ttcttgagct tgacaaagat gaacttattg attatatttg tagtgatgaa cttgttattg     1020

gtaaagagga gatggttttt gaagccgtca tgcgttgggt ctatcgtgcc gttgatctga     1080

gaagaccact gttacacgag ctcctgacac atgtgagact ccctctgttg catcccaact     1140

actttgttca aacagttgaa gtggaccaat tgatccagaa ttctcctgag tgttatcagt     1200

tgttgcatga agcaagacgg taccacatac ttgggaatga aatgatgtcc ccaaggacta     1260

ggccacgcag gtccactggc tattctgagg tgatagttgt cgttggagga tgtgagcgag     1320

ttggaggatt taatcttcca tacactgagt gctacgatcc tgtaacagga gaatggaagt     1380

ctttggctaa gcttccagaa tttaccaaat cagagtatgc agtctgtgct ctaaggaatg     1440

acattcttgt ttcaggtgga agaatcaaca gccgtgatgt ctggatttat aactcacagt     1500

taaatatttg gatcagagtt gcctctctca ataaaggcag atggcgtcac aaaatggctg     1560

tcctccttgg taaagtatat gttgtcggtg gctatgatgg gcaaaacaga cttagcagcg     1620

tagaatgtta tgattccttt tcaaatcgat ggactgaagt tgctcccctt aaggaagccg     1680

tgagttctcc tgcagtgact agctgtgtag gcaaactgtt tgtgattggt ggaggacctg     1740

atgataatac ttgttctgat aaggttcaat cttatgatcc agaaaccaat tcttggctac     1800

ttcgtgcagc tatcccaatt gccaaaaggt gtataacagc tgtatcccta aacaacctga     1860

tctatgttgc cggtggactg accaaggcaa tatactgtta cgatccagtt gaagattact     1920

ggatgcacgt acagaataca ttcagccgtc aggaaaactg tggtatgtct gtgtgtaatg     1980

gtaaaatata tatcctgggc ggaagacggg aaaatggaga agccacagac actattctct     2040

gttatgatcc tgcaacaagt atcatcacag gggtagctgc aatgcccagg ccagtgtcct     2100

atcatggctg tgtgactatt catagataca atgagaaatg ctttaaactc tgaagacagg     2160

atacctcacc gaagaagcca cactgatcca agatgggagg ttttaaaaac tctacagtgg     2220

gaacttcaca tatctccttt gtgccatatg caaaaaatag taaaaataat aatttggtgc     2280

ctttctcctc aaaatatcaa tctttcaaac tataataaag cctttcctat aattgaaaaa     2340

aaaaa                                                                 2345


<210> 267
<211> 1576
<212> DNA
<213> Homo sapiens

<400> 267
taaatatttt ttgctttagt ttttcttata aggctaaaaa ttcacaaagc atatatcaat       60

gaatcaggag gatctagatc cggatagtac tacagatgtg ggagatgtta caaatactga      120

agaagaactt attagagaat gtgaagaaat gtggaaagat atggaagaat gtcagaataa      180

attatcactt attggaactg aaacactcac cgattcaaat gctcagctat cattgttaat      240

tatgcaagta aaatgtttaa ccgctgaact cagtcaatgg cagaaaaaaa cacctgaaac      300

aattcccttg actgaagacg ttctcataac attaggaaaa gaagagttcc aaaagctgag      360

acaagatctt gaaatggtac tgtccactaa ggagtcaaag aatgaaaagt taaaggaaga      420

cttagaaagg gaacaacggt ggttggatga acagcaacag ataatggaat ctcttaatgt      480

actacacagt gaattgaaaa ataaggttga aacattttct gaatcaagaa tctttaatga      540

actgaaaact aaaatgctta atataaaaga atataaggag aaactcttga gtaccttggg      600

cgagtttcta gaagaccatt ttcctctgcc tgatagaagt gttaaaaaga aaaagaaaaa      660

cattcaagaa tcatctgtaa acctgataac actgcatgaa atgttagaga ttcttataaa      720

tagattattt gatgttccac atgatccata tgtcaaaatt agtgattcct tttggccacc      780

ttatgttgag ctgctgctgc gtaatggaat tgccttgaga catccagaag atccaacccg      840

aataagatta gaagctttcc atcagtaaaa ggatgttttc ttttttcaca cagtaaaaat      900

tcttatcatt caaggatatt ggaaccacag gactatttgg ataaaaaaca ttatttgcaa      960

attaatgcgc ataggccatc ttacttttat tgcaaaatgg catgtgctgc catctattat     1020

tcatttttaa atggtcattt cttattcagt gagtgcttta gtgttttaaa ctatatggat     1080

aagaatgcag gtagataata ttctaggcat aaaacattta atgtacctta cctcatgcaa     1140

tattctttgg attctttgtt gatttatgat attgctaata taatattttc ttaaaatata     1200

taacaatatc ttttatgcat tttgagttcc agctggtgct tctttatatt tagaaattat     1260

aatgggaagg tcatttaatt tacagatggt tttaaaattg aggtaatatc tgaggtggca     1320

taatttaaaa atatttagca aatttgtttc atatatactg tcttatttct agatttgttt     1380

aaaattggaa tatgaaaaac taatggataa agctagcata aaattgatat tttagtttgt     1440

attattaata tatcatgtta ccttatatat taatctactc ttgattctgc taattattac     1500

caacaaaatt gtattcatga cattttatta atcctctgtg aattttctgt aaataaaatt     1560

atttctgaaa atctct                                                     1576


<210> 268
<211> 1579
<212> DNA
<213> Homo sapiens

<400> 268
cggaagccac ggttgcccgg caacaacaag tcccgtcggg tggcagcggc tggcggcaaa       60

acctctcgag tgagcccctg cccgagtgcc gcgggggaga ggccgcgagc gggaccgaga      120

agtgggctgg gagcagaggt cgcggaggtg gcgagcgagg ccggggccca ggcggggacc      180

ggcaggggcc cgggagtggc gggcacgcca gggtcagggt gccgggcgag ggagggggcc      240

cggggttggg gaagggggcc cggggaggga ggtaaacagc cctgcaggcc tcggggcacc      300

gttgctgggc ggcgccggcg gcatgtgcga gggcccgtcc cgcatctcgg ggcccatccc      360

cccagacccg acgctctgtc ctgacaacta caggcggccg acctcggctc aagggcgcct      420

cgagggaaac gcgctgaagc tggacttgct gacttccgac cgggccctgg acaccaccgc      480

tccccgtggc ccctgcatcg gtcccggtgc cggagagatc ctggagcgcg gccagcgcgg      540

cgtcggggac gtgctgttgc aactcgaggg gatctcccta ggtcctgggg cctctctcaa      600

gaggaaggac cctaaggacc atgagaagga gaacctgagg cggatcaggg agattcagaa      660

gcgcttcaga gaacaggagc gcagccggga gcagggccag cccaggcccc tgaaagctct      720

gtggcgctca cccaagtacg acaaggtgga gtcccgggtc aaggcccagc tccaggagcc      780

tggccctgcc tctgggacag agtctgccca cttcctgcgg gcgcactccc gctgcggccc      840

tggcctccca ccaccccatg tatctagtcc ccagccaacc ccaccaggtc ccgaagctaa      900

ggagccaggc ctgggggtgg acttcattcg tcacaatgca cgagctgcca agagagcccc      960

ccggaggcat tcctgctcac tgcaggtcct ggcacaagtg ctagagcagc agcggcaggc     1020

ccaggagcac tacaatgcca cgcagaaggg ccatgtgcca cattacttgt tggagcgcag     1080

ggacctgtgg cggcgggagg ccgaggcccg caagcagagc cagccggacc ctgccatgcc     1140

cccaggccac acgcgcatgc ctgagaacca gcggctggaa acactgacca agctgctcca     1200

gagccagagc cagctgctgc gtgagctggt actgctgcct gctggggcag actcactgag     1260

agcccagagc caccgtgctg agctggaccg gaagctggtg caggtagagg aggccatcaa     1320

gatcttttct cggcccaaag tcttcgtgaa gatggacgac tgagcccctt tgggggacag     1380

tggcaaggag ctccatgctg aggatcgcca catggctgca aaggacaggg ttggacccaa     1440

tcccagagca gaggtctgaa gacaggagca ggggggtggc cagtgtccct agagcactct     1500

tcccagtcac cagtggctgc agaagggcca ccctagcctt ttaactgctt tgtcaaaatt     1560

aaacattttg tacacagga                                                  1579


<210> 269
<211> 2236
<212> DNA
<213> Homo sapiens

<400> 269
actgcgccga ggggcggggc tggacgcgcg ctccaagatg gcggcgaacg tgttcccgtt       60

ccgcgacgcc cgtgccgcac cggacccagt gctggaggcc ggcccggtgg cacacgggcc      120

actgccggta ccgctggtgc tggacaacgg gtcgttccaa gtccgcgctg gctgggcgtg      180

tcccgggcag gacccaggtc ccgagccgcg cctgcagttc cgcgcggtgt gcgcccgcgg      240

tcgtggcggg gcacggggcg cgtcgggccc gcaggtgggg aacgctctgg gcagcctgga      300

gccactgcgc tggatgctgc gctcgccctt cgaccgcaac gtgccggtca acctggagct      360

tcaggagttg ctgctggact acagcttcca gcacctgggt gtctcctcac agggctgtgt      420

tgatcatccc atagttttga cagaagctgt gtgcaaccca ctgtattcac ggcaaatgat      480

gtctgagctt ctttttgagt gctacgggat tcccaaggtt gcctatggaa tagacagcct      540

cttcagcttc taccacaata agccaaagaa ctcgatgtgc agtgggctaa tcatttcatc      600

tggataccag tgtacgcatg ttttacccat cttagaaggg agattagatg ctaaaaactg      660

caagcgcatc aatcttggag gaagccaagc agctggttac ctccagcgtc tcctccagct      720

gaagtaccct gggcacctgg cagccatcac cctcagccgc atggaggaga ttctgcatga      780

gcacagctac atcgctgagg attatgtgga agaattacac aaatggcggt gtcctgatta      840

ttatgagaat aatgtccaca agatgcagct cccattttcc agcaagctcc tgggcagcac      900

tctgacctct gaggagaaac aagaaaggcg gcagcagcaa ttgcggcggc tgcaggagct      960

caatgcccgg cggcgggagg agaagctgca gctggatcag gagcgtctgg accgactgct     1020

atatgtgcag gaacttctag aggatggcca gatggatcag tttcacaaag ctctgataga     1080

gctgaatatg gactccccag aagagctgca gtcctacatc cagaagctca gtatagcagt     1140

ggagcaggct aagcagaaaa tcctccaagc ggaagtcaac ctcgaggtgg atgtggtaga     1200

cagcaagcca gagacccctg acctggagca gctggagccg tctttggaag atgtggaaag     1260

catgaatgat tttgatccct tgttttcaga ggaaacacct ggagtggaga agccggtcac     1320

cactgttcag cccgtgttta acttggcagc atatcatcag ctatttgttg ggacagaaag     1380

aattcgagct ccagagatta ttttccagcc atctctcata ggagaagaac aggctgggat     1440

tgcagagact cttcagtaca ttctggacag gtacccaaag gacattcagg aaatgctggt     1500

tcagaacgtt ttcctcactg gcggcaacac gatgtatcct ggcatgaaag ccagaatgga     1560

gaaggaactg ttggagatga gacccttccg gtcttctttt caggttcaac ttgcctcgaa     1620

ccctgtgctg gatgcctggt acggtgctcg tgactgggcc ttgaaccacc tagatgataa     1680

tgaagtttgg atcaccagga aagagtatga agaaaaggga ggagagtacc tcaaggagca     1740

ctgtgcttcc aacatctatg tccccatccg cctgccgaag caggcctccc gctcctcaga     1800

tgcccaggca tccagcaagg gctccgctgc tggtggaggt ggtgctggtg agcaggcata     1860

gcagaggccc tccagagaga ctgccctgca cgccatgcct tgggccacgt tggcagtgtg     1920

acaggactgt gattgtgcta gatgtacctg cccaagtctg ctggtcacat ttggcagcaa     1980

aatggatttc tcctggggag aacaaagtta agggacactg agacctgccc ttcagaattc     2040

ggttcacttg ggggcttctg tggtagagac taactggcct tctgatgtct ttgttcaact     2100

gtggccagct gtggcatcag cttcctggag cagtaaatga agacagagtg gaggacacaa     2160

atgtacaaaa tgcacaagac tgatttctta ccacatttta gtctttcttg ttttaaaaaa     2220

aattctttaa aattta                                                     2236


<210> 270
<211> 2458
<212> DNA
<213> Homo sapiens

<400> 270
ttccggaaga ggtcgccatg gcttcccggg aggaggtact cgccttacaa gctgaagttg       60

cccaacgtga ggaggaattg aattcgctga agcagaagct ggcgtcggct cttttggctg      120

agcaggaacc gcagccagaa cggctggttc cggtgtcgcc gctgccgccg aaggccgctc      180

tgtcccgaga tgagattctg cgctatagcc ggcagctagt gctgcccgag ctgggcgtgc      240

acggacagct gcgcctgggg accgcgtgcg tgctaatcgt gggctgcggt gggctcggct      300

gtccactagc gcagtacttg gcagcggccg gcgtgggccg ccttggcctt gtggactatg      360

acgtggtaga gatgagcaac ctggcccgcc aagtgctgca tggcgaggca ctggctggcc      420

aggccaaggc cttttcggcc gccgcctcgc tgcgccgcct caattcggca gtggaatgcg      480

tgccgtacac tcaggccctt acgccagcca ctgccctaga cctggtccgc cgatatgatg      540

tggtggctga ctgctcggac aacgtgccca ctcgctacct ggttaatgac gcatgtgtgc      600

tggcgggtcg gcccctcgtg tctgccagtg ccttgcgctt cgagggccaa atcacagtct      660

accattatga cggtggccct tgctatcgct gcatattccc ccaaccaccc ccagcggaga      720

cagtgaccaa ctgcgcggac ggcggggtgc tcggtgtcgt taccggggtc ctgggctgcc      780

tgcaggcctt ggaagtgctg aaaatcgctg cgggtctggg cccctcttac agtggcagct      840

tgttgctctt tgatgccctg agagggcatt tccgctctat tcggctgcgg agccgcaggc      900

tcgactgtgc agcttgcggg gaacggccca ctgtgactga tctgctggac tatgaagcct      960

tctgtggctc ctcagccact gataaatgcc gctccctgca actactgagc ccagaggagc     1020

gtgtttctgt caccgactat aagcgactgc tggattctgg ggcattccac ctgttgctgg     1080

acgtcaggcc tcaggtggag gtggacattt gtcgtttgcc tcatgcccta cacatccctc     1140

tgaaacattt ggaacgcagg gatgcggaga gcctgaaact cttaaaagaa gcaatctggg     1200

aagagaagca gggcacacaa gaaggggctg ctgtccccat ttatgtgatt tgcaaactgg     1260

gaaatgactc acagaaagcc gtgaagatcc tccagtcctt atcagcagct caagagttag     1320

accctttaac agttcgggat gttgtggggg gcctcatggc ctgggctgcc aaaatcgatg     1380

gaacatttcc acagtactga ggtgactggt atagtctgat gagaaagatg tggattgcca     1440

taatacctca aagatacact tgtttgcatt tttcggtaat atacatagga gctggggatt     1500

ctacagtatc tgtgaatacg tggactcctt tttataagga gttttaaaaa ttgttatgta     1560

ttggatgaat gacttattaa tggattatac cgtttctgag aaccatcatt ttttttttca     1620

gcacacggag gatgtcttgg acatgtgaga tgtaacgtga caggattttg cattttaaac     1680

tgcagatcat ttacatgtcc ttattttcca cctcccccag tcaaaatgct ttctaaatca     1740

ttttcacaga ttatatactt cggatctgtt tactgttcag ttaagaaatt cttggatctt     1800

attaatattt cagatgatag aatacatcct acagaaatac atgtttaaaa tgtaaattgt     1860

tttaattatt cagaaagagg gtcattctat ttggcctttt gaattagtat caaaatgaga     1920

tttttttttt ttttttgaga tggaatctct ctctgttgcc caggctggag tgtagtggtg     1980

cgatctcagc tcactgcaac ctccgcctcc caggttcaag cgattctcct gcctcagcct     2040

cctgagtagc tgggattaca ggcgcacgcc accacgcctg gctaattttt gtatttttag     2100

tacagagggg gtttcaccat gtttgtcagg ctggtctcga actcctgacc tcgtgatccg     2160

cctgcctcga cttcccagag tgctgggatt acaggcgtga gccaccacac cctcccgaga     2220

tctttaaagt ttaccaaaat aaaggaaacc acctttgtag tctgtcagtg tctcttataa     2280

attgctactg ttttcttaaa gttaacttca gggtccacct tatgttgcac acatatcaca     2340

tcgtttaaat tgcatactat ggtttgactt gctttggaat tttcaagtca aagtcccaac     2400

cctttgcctc tcccccttta atttgccttt tctcttttga tttaatgttt ttttattc       2458


<210> 271
<211> 2137
<212> DNA
<213> Homo sapiens

<400> 271
ctctcccatc gcagtgcccc ttgccttctc ctgccctagt aactgcctgc ggggatccag       60

gagcccccag gccgcgccga actgcagtgg atagggggga ggggggcggt aaggatgagg      120

gctacgggga ggcagaaatg ggttggggga aggggtggtg gaagggaaaa gaaaaaaccg      180

gaggcatgca agcggctccc cagccagctg ttccagctgc tgcttcctcc ggcgcgggcc      240

aggcggtgca atattccccc ccgctccatc tttctcacca ctacctgtcc ccccaaccca      300

ccacacgcac tcatccctcc cacccacacc cctagtagcg gatctccggc ctgtaagggg      360

gtagtaggga ggagctgggg ggagggggag gcctgcgagt ttctaacctt gttcttataa      420

acaaacccac atgtgcagct gccgctgctg caactcaccc cacaatcccg gatataagtc      480

ctgccccttt aagaggaaaa aaaagattcc cccgcctgcc tcccacccca cccatccaca      540

agagagagga agcttgaagc caatatggag tccgtcagtt gctccgctgc tgctgtcagg      600

accggagaca tggagtccca gcgggacctg agcctggtgc ctgagcggct tcagagacgc      660

gaacaagaac ggcagctgga agttgaaagg cggaaacaaa agcggcagaa ccaggaggta      720

gagaaggaga acagccactt tttcgtcgcc acctttgttc gggagcgagc ggccgtggaa      780

gagcttctgg agcgcgcgga gtcggtcgag cggctggagg aggcggcctc tcggctccag      840

gggctgcaga aactaatcaa cgactcagtt tttttcctag ccgcttacga cctgcggcag      900

ggacaagagg cgctggcgcg gctgcaggcg gccttggccg agcggcgccg ggggctgcag      960

cccaagaagc gtttcgcttt caagacccgg ggaaaggatg ctgcttcgtc taccaaagta     1020

gacgcggctc ctggcatccc cccggcagtt gaaagcatac aggactcccc gctgcccaag     1080

aaggcggaag gagacctcgg ccccagctgg gtctgcggtt tctccaacct ggagtcccaa     1140

gtcttggaga agagagccag cgagttgcac cagcgcgacg ttcttttgac cgaactgagc     1200

aactgcacgg tcagactgta tggaaatccc aacaccctgc ggctaaccaa ggcccacagc     1260

tgcaagctgc tctgcggtcc ggtgtctacc tctgttttcc tggaggactg cagtgactgc     1320

gtgctggcag tggcctgcca acagctccgc atacacagta cgaaagacac ccgcatcttc     1380

ctgcaggtga ccagcagggc catcgtggag gactgcagtg ggatccagtt cgccccttac     1440

acctggagct acccggagat cgacaaggac ttcgagagct ctggtttaga taggagcaaa     1500

aataactgga acgatgttga cgattttaac tggctggccc gggatatggc ctccccaaac     1560

tggagtattc ttcctgaaga ggagcgaaat atccagtggg actaagcagt tgtcactctg     1620

ttcttcactc ctaccaaata ctttccacgt tggactttcc cccttattgg gtctcgaagt     1680

ttacttattg tcacactgtg tatgttttca gcattttaag gctagagatt gtaatgggct     1740

cctacttgta atttccatta aattcgtaac aggtataaca ctaaagcatt tttgctattt     1800

tcgtcatgcc tttgagactg agtcttactc cgtcccccag cgtggtggcg cgctgggatt     1860

acaggcgcgc gccaccacgc gaacttgtat ttttagtaga gacggggttt cgccatgttg     1920

tccgggctgc tctcgaactc ctgacctcag gtgatccacc cgcttcagct tcccaaagtg     1980

ctggcattac aggcgtgagc caccacgcca gggctttatt tatttatttt taccacaata     2040

gtttgaagca gtaaggggga aggagggtga ttatattgct ttgtaatggt ttgtgatact     2100

tgaaacatca cggtgcataa taaagtaggt ctgcagt                              2137


<210> 272
<211> 1749
<212> DNA
<213> Homo sapiens

<400> 272
gtttatctcg ttggggacta aggcgtcggt tggcgcgcaa cgggttctag gctgcaggca       60

gctcgaggac ccgcggcccc gccccggctc ggcctggcag atagcagagg cagcaggccg      120

tgccgggggg gcatgttgct gtaaccagtg gcccagggga tgttacggtg gacagtgcac      180

ctggagggcg ggccccgcag ggtgaaccat gctgcagtgg ctgtcgggca tcgggtatac      240

tccttcgggg gttactgctc tggtgaagac tatgagacac tgcgtcagat agatgtgcac      300

attttcaatg cagtgtcctt gcgttggaca aagctgcccc cggtgaagtc tgccatccgt      360

gggcaagctc ctgtggtacc ctacatgcgc tatggacact caaccgtcct catcgacgac      420

acagtcctcc tttggggcgg gcggaatgac accgaagggg cctgcaatgt gctctatgcc      480

tttgacgtca gcggactgtt tttccaatga cattcacaag ctagatacca gcaccatgac      540

atggactctt atctgtacaa agggcagccc tgcacgctgg agggacttcc actcagccac      600

aatgctggga agtcacatgt atgtctttgg gggccgtgcc gaccgctttg ggccattcca      660

ttccaacaat gagatttact gcaaccgcat tcgagtcttt gacaccagaa ctgaggcttg      720

gctggactgt cccccgactc cagtgctgcc tgaggggcgc cggagccact cggcctttgg      780

ctacaatggg gagctgtaca tctttggtgg ttataatgca aggctgaacc ggcacttcca      840

tgacctctgg aagtttaatc ctgtgtcctt tacctggaaa aagattgaac cgaaggggaa      900

ggggccatgt ccccgccggc gccagtgctg ctgtattgtt ggtgacaaga ttgtcctctt      960

tgggggtacc agtccatctc ctgaggaagg cctgggagat gaatttgacc ttatagatca     1020

ttctgactta cacattttgg actttagccc tagtctgaag actctgtgca aactggccgt     1080

gattcagtat aacctagacc agtcctgttt gcctcatgat atcaggtggg agctgaatgc     1140

catgaccacc aacagcaata tcagtcgccc catcgtctcc tcccatgggt aggaggaagt     1200

ttctgccacc tcccctcctg agcctgctgt catcttcact gcccctgccc atctgtcacc     1260

cacctgctcc tttgacccct ggacttggta tacctccatg tggagttgtt gggcgagagg     1320

tgttctctgt gctgtgaatt cagtggggag ctgtagcggg gtgggggcta ggttcctccc     1380

cccttgggcc gagggcccct tccccttggt gctctgtccc catccacctc ctttcagctg     1440

ctcctgggcc tcagctctgc ccagggccag ccaggttctg ctgggaaggg aagggaatgg     1500

ggagaaggga gaagcaagca gtgtctgagc ctcaggagct tccccctccc cctttgccta     1560

tcccctcccc tctgcttgag ccttgagcct tgactgggag ctgaaaggag ttgcagctgt     1620

tggcatgaga cctccttctc cccgtcttgg ggaggtgggg accagcagat aaatcccacc     1680

cttccttgag ctgtcgctgt actctgaagt tcagccagct cagattttat aaaaattaat     1740

taaaatctc                                                             1749


<210> 273
<211> 2832
<212> DNA
<213> Homo sapiens

<400> 273
agtaactgac tacttttctc ccttctctag ggtcctagca cagtgtctga tggagctttc       60

ctaccagacc ctgaaattca cgcatcaggc gcgggaagcg gtatatcgat acagcaaatg      120

ctttggagca agaaactaaa ctggggttac gacggtttga agtttgtgac aacattgatc      180

ttgaaactat tttgatggaa tatgagagtt attattttgt aaaatttcag aaatacccca      240

aaattgtcaa aaagtcatca gacacagcag aaaataattt accgcaaaga agtagaggga      300

agaccagaag gatgatgaac gacagttgtc aaaatcttcc caagatcaat cagcagaggc      360

cccggtccaa aaccacagcg gggaagacag gggacaccaa atcgctcaat aaggagcatc      420

ctaatcagga ggtagttgat aacactcgcc tggaaagtgc caacttcggc ctacatatat      480

caagaatccg taaagacagt ggagaggaaa atgcccaccc acgaagaggc caaatcattg      540

acttccaagg gctgctcaca gatgccatca agggagcaac cagtgaactt gccttgaaca      600

ccttcgacca taatccagac ccctcagaac gactgctgaa acctctgagt gcatttattg      660

gcatgaacag tgagatgcga gaattggcag ccgtggtgag ccgggacatt tatctccata      720

atccaaacat aaagtggaat gacattattg gacttgatgc agccaagcag ttagtcaaag      780

aagctgttgt gtatcctata aggtatccac agctatttac aggaattctt tctccctgga      840

aaggactact gctgtacggc cctccaggta caggaaagac tttactggcc aaagctgtgg      900

ccactgaatg taaaacaacc ttctttaaca tttctgcatc caccattgtc agcaaatgga      960

gaggggattc agaaaaactc gttcgggtgt tatttgagct tgcccgctac cacgccccat     1020

ccacgatctt cctggacgag ctggagtcgg tgatgagtca gagaggcaca gcttctgggg     1080

gagaacatga aggaagcctg cggatgaaga cagagttact ggtgcagatg gatgggctgg     1140

cacgctcaga agatctcgta tttgtcttag cagcttctaa cctgccgtgg gagctggact     1200

gtgccatgtt acgccgcctg gagaagagga ttctggtcga tctccccagc cgggaggcca     1260

ggcaggccat gatctaccac tggctgcctc ctgtgagcaa gagcagggcc ttggagctgc     1320

acacagagct ggagtacagt gtgctgagcc aggagactga gggctactca ggctcagata     1380

ttaagctcgt ctgcagggaa gcagccatgc ggcccgtgag gaagatcttt gatgcacttg     1440

aaaatcacca gtcagaaagc agcgacttac ccaggatcca gttggatata gtaaccactg     1500

ccgactttct ggatgtgcta actcacacca agccctccgc aaagaatctg gctcagagat     1560

actcagactg gcaaagagag ttcgagtctg tctgaaacca catttaccct gacctggcca     1620

caaaggcaac cacaaagacc tcctagttta ttaatgtccg tgggagaaca aaatgattgg     1680

aatggaaaag agaaaattat ttttgaagac tggattaact tgagccactg tattgttttg     1740

gatagctgag atatatttat taacttacca ttatcgatgt cagcaaaata ttgagagttt     1800

cagttacata catatatgtg ctattgggtc atacaatgga gatttttctg acaattagac     1860

tccataaaat tttaatgaac aattttctgt aatgttactc atttgtaaac tttttaagaa     1920

aaagatgtac ttagaaaagt tgtgttggcc acacacagga tgaccctgag ttggggcagc     1980

caagtagaag ctaagcttga caggcactgc ccagctgaca gtcccagggt gaaggaggac     2040

ggaagcaggg aaggcaatgc agtctgtttc tcattccgga caatattctg aatctcatca     2100

gctcccccta attctgactc catccagctt tgtcagcagc aaacccctcc caaactaagc     2160

cccactcaga aatgtcactg agcattctga tgctagagct aatagccagg gtgactagca     2220

caccatcacc atcagctgcc agtctgattg ttttgggttc tggcccccaa taacatcttt     2280

tcactcttca cacctcacat ccggtgtgct ctgcccttct ctttccattg ccgcagcttc     2340

tcatcagatc caaagcttag gatggggcac ctaagcttcg agaacattca tcccaagtct     2400

tccctgctct taggctcttc cccctctcct taaggggtta taaacaacta gacgcatctc     2460

tctcagaaac ccacaatccg aggcatctac tttcaaccct tgataaattt tgaaggcttc     2520

tactaagtaa tgccacttct tttcccccac tagaacttac ctatgggaaa tcaccttctt     2580

ttctcttcct tgccttgtct tcatcatccc tgcagacaga ctcttcaaga ggaaaaacct     2640

ccagaaagag acactttgga tagctaagta tcccaaagga ttttaccctt ttaaacaaaa     2700

ccaaagcatt tttttcggta tcgattattt tgagattatt ctcaaatgcc tctttaaaca     2760

tcatttcatg gaaaatgtca aattgaaaat ataccttatt taacaaattg aaaataaaaa     2820

agatttcatc tc                                                         2832


<210> 274
<211> 10293
<212> DNA
<213> Homo sapiens

<400> 274
ccgagccggg agccgagcgc gctgggcgcg gccgtcccgc tgccgccgcc aagcccggag       60

tgcgccagcg gccatggttc ccgcggcggc gccgggcgcc tgagccccgg gacgcaagcg      120

ctggaggcgg gctgccggct gtgcgggcgc tccggagaga ccgacagaag gtgagcactg      180

tgggctatgg gatggatgag gtggagcagg accagcatga ggcccgactc aaggagctgt      240

ttgacagttt tgacacgacg ggcacagggt ccctggggca ggaggaactc accgaccttt      300

gccacatgtt gagcttggag gaggtggccc cagtgctgca gcagacatta cttcaggaca      360

acctcttggg cagggtacat tttgaccaat ttaaagaagc attaatactc atcttgtcca      420

gaactctgtc aaatgaagaa cactttcaag aaccagactg ctcactagaa gctcagccca      480

aatatgttag aggtgggaag cgttacggac gaaggtcctt gcccgagttc caagagtccg      540

tggaggagtt tcctgaagtg acggtgattg agccactgga tgaagaagcg cggccttcac      600

acatcccagc cggtgactgc agtgagcact ggaagacgca acgcagtgag gagtatgaag      660

cggaaggcca gttaaggttt tggaacccag atgacttgaa tgcttcacag agtggatctt      720

cccctcccca agactggata gaagagaaac tgcaagaagt ttgtgaagat ttggggatca      780

cccgtgatgg tcacctgaac cggaagaagc tggtctccat ctgtgagcag tatggtttac      840

agaatgtgga tggagagatg ctcgaggaag tattccataa tcttgatcct gacggtacaa      900

tgagtgtaga agattttttc tatggtttgt ttaaaaatgg aaaatctctt acaccatcag      960

catctactcc atatagacaa ctaaaaaggc acctttccat gcagtctttc gatgagagtg     1020

gacgacgtac cacaacctca tcagcaatga caagtaccat tggctttcgg gtcttctcct     1080

gcctggatga tgggatgggc catgcatctg tggagagaat actggacacc tggcaggaag     1140

agggcattga gaacagccag gagatcctga aggccttgga tttcagcctc gatggaaaca     1200

tcaatttgac agaattaaca ctggcccttg aaaatgaact tttggttacc aagaacagca     1260

ttcaccaggc ggctctggcc agctttaagg ctgaaatccg gcatttgttg gaacgagttg     1320

atcaggtggt cagagaaaaa gagaagctac ggtcagatct ggacaaggcc gagaagctca     1380

agtctttaat ggcctcggag gtggatgatc accatgcggc catagagcgg cggaatgagt     1440

acaacctcag gaaactggat gaagagtaca aggagcgaat agcagcctta aaaaatgaac     1500

tccgaaaaga gagagagcag atcctgcagc aggcaggcaa gcagcgttta gaacttgaac     1560

aggaaattga aaaggcaaaa acagaagaga actatatccg ggaccgcctt gccctctctt     1620

taaaggaaaa cagtcgtctg gaaaatgagc ttctagaaaa tgcagagaag ttggcagaat     1680

atgagaatct gacaaacaaa cttcagagaa atttggaaaa tgtgttagca gaaaagtttg     1740

gtgacctcga tcctagcagt gctgagttct tcctgcaaga agagagactg acacagatga     1800

gaaatgaata tgagcggcag tgcagggtac tacaagacca agtagatgaa ctccagtctg     1860

agctggaaga atatcgtgca caaggcagag tgctcaggct tccgttgaag aactcaccgt     1920

cagaagaagt tgaggctaac agcggtggca ttgagcccga acacgggctc ggttctgaag     1980

aatgcaatcc attgaatatg agcattgagg cagagctggt cattgaacag atgaaagaac     2040

aacatcacag ggacatatgt tgcctcagac tggagctcga agataaagtg cgccattatg     2100

aaaagcagct ggacgaaacc gtggtcagct gcaagaaggc acaggagaac atgaagcaaa     2160

ggcatgagaa cgaaacgcac accttagaaa aacaaataag tgaccttaaa aatgaaattg     2220

ctgaacttca ggggcaagca gcagtgctca aggaggcaca tcatgaggcc acttgcaggc     2280

atgaggagga gaaaaaacaa ctgcaagtga agcttgagga ggaaaagact cacctgcagg     2340

agaagctgag gctgcaacat gagatggagc tcaaggctag actgacacag gctcaagcaa     2400

gctttgagcg ggagagggaa ggccttcaga gtagcgcctg gacagaagag aaggtgagag     2460

gcttgactca ggaactagag cagtttcacc aggagcagct gacaagcctg gtggagaaac     2520

acactcttga gaaagaggag ttaagaaaag agctcttgga aaagcaccaa agggagcttc     2580

aggagggaag ggaaaaaatg gaaacagagt gtaatagaag aacctctcaa atagaagccc     2640

agtttcagtc tgattgtcag aaagtcactg agaggtgtga aagcgctctg caaagcctgg     2700

aggggcgcta ccgccaagag ctgaaggacc tccaggaaca gcagcgtgag gagaaatccc     2760

agtgggaatt tgagaaggac gagctcaccc aggagtgtgc ggaagcccag gagctgctga     2820

aagagactct taagagagag aaaacaactt ctctggtcct gacccaggag agagagatgc     2880

tggagaaaac atacaaagaa catttgaaca gcatggtcgt cgagagacag cagctactcc     2940

aagacctgga agacctaaga aatgtatctg aaacccagca aagcctgctg tctgaccaga     3000

tacttgagct gaagagcagt cacaaaaggg aactgaggga gcgtgaggag gtcctgtgcc     3060

aggcaggggc ttcggagcag ctggccagcc agcggctgga aagactagaa atggaacatg     3120

accaggaaag gcaggaaatg atgtccaagc ttctagccat ggagaacatt cacaaagcga     3180

cctgtgagac agcagatcga gaaagagccg agatgagcac agaaatctcc agacttcaga     3240

gtaaaataaa ggaaatgcag caggcaacat ctcctctctc aatgcttcag agtggttgcc     3300

aggtgatagg agaggaggag gtggaaggag atggagccct gtccctgctt cagcaagggg     3360

agcagctgtt ggaagaaaat ggggacgtcc tcttaagcct gcagagagct catgaacagg     3420

cagtgaagga aaatgtgaaa atggctactg aaatttctag attgcaacag aggctacaaa     3480

agttagagcc agggttagta atgtcttctt gtttggatga gccagctact gagttttttg     3540

gaaatactgc ggaacaaaca gagcagtttt tacagcaaaa ccgaacgaag caagtagaag     3600

gtgtgaccag gcggcatgtc ctaagtgacc tggaagatga tgaggtccgg gacctgggaa     3660

gtacagggac gagctctgtt cagagacagg aagtcaaaat agaggagtct gaagcttcag     3720

tagagggttt ttctgagctt gaaaacagtg aagagaccag gactgaatcc tgggagctga     3780

agaatcagat tagtcagctt caggaacagc taatgatgtt atgtgcggac tgtgatcgag     3840

cttctgaaaa gaaacaggac ctactttttg atgtttctgt gctaaaaaag aaactgaaga     3900

tgcttgagag aatccctgag gcttctccca aatataagct gttgtatgaa gatgtgagcc     3960

gagaaaatga ctgccttcag gaagagctga gaatgatgga gacacgctac gatgaggcac     4020

tagaaaataa caaagaactc actgcagagg ttttcaggtt gcaggatgag ctgaagaaaa     4080

tggaggaagt cactgaaaca ttcctcagcc tggaaaagag ttacgatgag gtcaaaatag     4140

aaaatgaggg gctgaatgtt ctggttttga gacttcaagg caagattgag aagcttcagg     4200

aaagcgtggt ccagcggtgt gactgctgct tatgggaagc cagtttagag aacctggaaa     4260

tcgaacctga tggaaatata ctccagctca atcagacact ggaagagtgt gtgcccaggg     4320

ttaggagtgt acatcatgtc atagaggaat gtaagcaaga aaaccagtac cttgagggga     4380

acacacagct cttggaaaaa gtaaaagcac atgaaattgc ctggttacat ggaacaattc     4440

agacacatca agaaaggcca agagtacaga atcaagttat actggaggaa aacactactc     4500

tcctaggctt tcaagacaaa cattttcagc atcaggccac catagcagag ttagaactgg     4560

agaaaacaaa gttacaggag ctgactagga agttgaagga gagagtcact attttagtta     4620

agcaaaaaga tgtactttct cacggagaaa aggaggaaga gctgaaggca atgatgcatg     4680

acttgcagat cacgtgcagt gagatgcagc aaaaagttga acttctgaga tatgaatctg     4740

aaaagcttca acaggaaaat tctattttga gaaatgaaat tactacttta aatgaagaag     4800

atagcatttc taacctgaaa ttagggacat taaatggatc tcaggaagaa atgtggcaaa     4860

aaacggaaac tgtaaaacaa gaaaatgctg cagttcagaa gatggttgaa aatttaaaga     4920

aacagatttc agaattaaaa atcaaaaacc aacaattgga tttggaaaat acagaactta     4980

gccaaaagaa ctctcaaaac caggaaaaac tgcaagaact taatcaacgt ctaacagaaa     5040

tgctatgcca gaaggaaaaa gagccaggaa acagtgcatt ggaggaacgg gaacaagaga     5100

agtttaatct gaaagaagaa ctggaacgtt gtaaagtgca gtcctccact ttagtgtctt     5160

ctctggaggc ggagctctct gaagttaaaa tacagaccca tattgtgcaa caggaaaacc     5220

accttctcaa agatgaactg gagaaaatga aacagctgca cagatgtccc gatctctctg     5280

acttccagca aaaaatctct agtgttctaa gctacaacga aaaactgctg aaagaaaagg     5340

aagctctgag tgaggaatta aatagctgtg tcgataagtt ggcaaaatca agtcttttag     5400

agcatagaat tgcgacgatg aagcaggaac agaaatcctg ggaacatcag agtgcgagct     5460

taaagtcaca gctggtggct tctcaggaaa aggttcagaa tttagaagac accgtgcaga     5520

atgtaaacct gcaaatgtcc cggatgaaat ctgacctacg agtgactcag caggaaaagg     5580

aggctttaaa acaagaagtg atgtctttac ataagcaact tcagaatgct ggtggcaaga     5640

gctgggcccc agagatagct actcatccat cagggctcca taaccagcag aaaaggctgt     5700

cctgggacaa gttggatcat ctgatgaatg aggaacagca gctgctttgg caagagaatg     5760

agaggctcca gaccatggta cagaacacca aagccgaact cacgcactcc cgggagaagg     5820

tccgtcagtt ggaatccaat cttcttccca agcaccaaaa acatctaaac ccatcaggta     5880

ccatgaatcc cacagagcaa gaaaaattga gcttaaagag agagtgtgat cagtttcaga     5940

aagaacaatc tcctgctaac aggaaggtca gtcagatgaa ttcccttgaa caagaattag     6000

aaacaattca tttggaaaat gaaggcctga aaaagaaaca agtaaaactg gatgagcagc     6060

tcatggagat gcagcacctg aggtccactg cgacgcctag cccgtcccct catgcttggg     6120

atttgcagct gctccagcag caagcctgtc cgatggtgcc cagggagcag tttctgcagc     6180

ttcaacgcca gctgctgcag gcagaaagga taaaccagca cctgcaggag gaacttgaaa     6240

acaggacctc cgaaaccaac acaccacagg gaaaccagga acaactggta actgtcatgg     6300

aggaacgaat gatagaagtt gaacagaaac tgaaactagt gaaaaggctt cttcaagaga     6360

aagtgaatca gctcaaagaa caactctgca agaacactaa ggcagacgca atggtgaagg     6420

acttgtatgt tgaaaatgcc cagttgttga aagctctgga agtgactgaa cagcgacaga     6480

aaacagcaga gaagaaaaat tacctcctgg aggagaagat tgccagcctc agtaatatag     6540

ttaggaatct gacaccagcg ccattgactt ctacacctcc tttgaggtca tagccaaacc     6600

aaagggtaca ctcatatttg tgcactttac tgaaatagat gaacatttca gtaggttctc     6660

aacttaaaat taagcctaac ctaaaactgc cagcaacaca actggagttt ccatttatca     6720

taattagttt ttctaaatag acccttatgg gagtttgaaa ataaatactc acatatttca     6780

ctacttaaat tattcccaag atttgaattt attttaaaat tttaatagcc accaagaatg     6840

tggacatatg aaaattcaag aacctaaaaa ataccagttt tgaatgagtt tttgtggttt     6900

tggttttttt tttaattatt acaaatctat gtgtaaaatc tagatatttg aagtttgaga     6960

tctgatgaga atggttgtta taaactttat tttaaaacca aatttaggtg ttcttacata     7020

tttaaatact ggaaagtcat tataatagtt ttggttcttt gaattggtag acaattagta     7080

gagtataatt ggttaggagg cagggcttat taagtggtta ttaaccgctg acatcagaca     7140

aacccaaatc tgtagaattc taaccttcta acacctgtga cagtattacc actcttcttg     7200

tattatagat ttagaactga tttactcaat tgcactctta actaatgtta aaagcttact     7260

tgctttaaac agccttttct tctttctctt aaaagtttca tttggggagc tggtcttcta     7320

agaaacggat aaagccacat aattaaagca gttgaactat agggaaagca ctgaacaaac     7380

cactttggag taaatagcta ctcttagaaa agagggataa gcagaccatg taggttttct     7440

gtctctcaaa tcttagagtt cataaattta cttgaggttg cctcaagaac tcagggaaca     7500

atactgtaaa ctgtcttcct gaactactgt agggcctctc taagaatttg aaatgtataa     7560

accatgtgac ctcatttatt tgtcttatat atttacagcc atactagaat ttttatttct     7620

acgtttttag taaatttaat attctggggg aaaaaaggcc ttgattttag ggttaaaaac     7680

ctgacttata gaagagttta tttaatatag gtcaaaattt tctgtgtttc ttattccttc     7740

tatacctcaa atctgattct aagaatttct tactgtgata atcattggca tgccacctga     7800

ggtcaaggag tgccaaatag gactttccac tcatgctcaa gatcaaaact ttatagaaca     7860

gtcaacattt tagattcggt aacctttttt ttcttccaat tataatctct gctagccact     7920

tccgccagca gttggtggaa gacttactag gtgcagggca ctttccaagt tcatcacaac     7980

aacctgcttg ttttcatgag acaataatcc gaaaagttcg ctttgatata ttcctggagg     8040

gccaagccca tctatttaca aaaggtgaac agcaaaatca agcactgctt tatgggcagg     8100

aacacaagag aaagcaaact gcccaagaag tcatcatgtc agaaactcaa tctcaacaaa     8160

ataatttcca tcagggaact tcagggtttc ttgggggctt atgagtctca ccggtcaacc     8220

caggaggcct cactacaaga gccttgacaa ggcactgttt tttgtgggac tgggagttca     8280

cactgatgaa gcaaaccttt gaatttttgc acagctcttg tcagaaagcc ctgagttccc     8340

cctggataaa gagttaattt taatccttcc ctataattat acttcaaaat atttgacatc     8400

tgctattatg ccttctttag atctttcttc tgtggtgcag acatttctag taagtgtttg     8460

actacttgta tggcattagc tttcacagaa aattgtttca cttaaaactg tggattggcc     8520

taggctaagg acaaaaataa actaagtacc tgtagtgtat ttatgtgata tgtgtcaagt     8580

tactcaaagt tattgctgtt ggaactgaac aataatattt cccagatagc tggccttagc     8640

atgtgatcac ggttgttgta tttttaattt ttgtctttta cagtatgaga ggtgtaggtt     8700

aatttgttta tttcctataa atttgtattt atgtgtatat aaaatgtaca atgaatgtaa     8760

atatgacttt ctggaaagtt tagactacat ttagaatctc tattcaaaat caaaatgctg     8820

ctcaaatgaa tttaaccaac atctaggtgc ttaatttctc attttatccc acttatgaga     8880

ttgggaaaaa gatcaatatg agaaatacca tacagatacc ttaaatgtat gcatttgtgc     8940

aacaattttt gagaaggtga gtggcaattt ataatttagt tggcaattta taatagaact     9000

tatagctttt aaaagacctt ttaaagacat taaatgtaaa cttaaaaatg tttagatctt     9060

gtttcaaact ttacaatagc attcttcaaa atattaagtt atatatttta taggcattta     9120

gttgcttatt aaaagcactg attttcaaac tttttgattt aagaacaatt atttaagatc     9180

gtctcagaag atgggatctt cgtttcaaga aaagggaatc aagtttgcct ttgagataat     9240

acgttacact aagaaaagga aaatgtggat agtaaaaccc acctctctca tcctattgta     9300

ctctcttctg ctttttagaa gcctgcactt aagcttagat ttgtgaaggg agagtagaag     9360

gggagaagta gaaccacagt gttttattta tttttctaaa actcttacta aatccagatt     9420

ttttaaactg ttttaaatgt gaattcttcc cagaaatttc aatgcattgc atatttagcc     9480

ttcggcatat ttttcatgaa tagatcatga agtcataggc ttccaaggca taggaagaga     9540

tcttgcaggt ctagtatttt aataatgcac tattacccag ggcagatatt atgagaaact     9600

gtttcttctc taagggttta tggcagactt tgctttttta acatgtgaga aatgaatttt     9660

ttattttgtg atttatgtga tttcttttgc tgagtgaagg aaaggagaaa ttgttgctat     9720

tgtcagcatc ttaaaggtat ttccagtcaa ggcaaggcta agtgctttgt gatagtatta     9780

agcaagtcat gttttgaatg gattacctgt agtgactcat tggaatgata taattataca     9840

agtaatgcca aaaaccaagt caaagcctaa ttaaccaaag cactcattta aaaatcatca     9900

tgtttggacc tatctggacc tctcagcact gtaaaatagt tttggttttg tggcatatga     9960

atagctgttt aacaaatcaa agttagcttt ttgcttctca gcttttttgg gcaatacaag    10020

ttaagttctt aatggggaga cattatcatg gcatgactta agggaacatt ggtttgtgaa    10080

ggaaaaacag attatctaaa gccatctcta tgtttctgtt cagataaaga ttaatgagtt    10140

ctgtgtttat atcagctttg tatatttcat cttagccatt ctatcctaga aagattttaa    10200

tgtgagctta agatgtaaat aaataatttt gcaaacatgc cttttgtttt ctatataccc    10260

tgacctttta ataaagtttc agtgtattta tca                                 10293


<210> 275
<211> 2431
<212> DNA
<213> Homo sapiens

<400> 275
ggcggccccg tggagcagcg cagtatggcg ggcggggccc gggaggtgct cacactgcag       60

ttgggacatt ttgccggttt cgtgggcgcg cactggtgga accagcagga tgctgcgctg      120

ggccgagcga ccgattccaa ggagcccccg ggagagctgt gccccgacgt cctgtatcgt      180

acgggccgga cgctgcacgg ccaggagacc tacacgccgc gactcatcct catggatctg      240

aagggtagtt tgagctccct aaaagaggaa ggtggactct acagggacaa acagttggat      300

gctgcaatag catggcaggg gaagctcacc acacacaaag aggaactcta tcccaagaac      360

ccttatctcc aagactttct gagtgcagag ggagtgctga gtagtgatgg tgtctggagg      420

gtcaaatcca ttcccaatgg caaaggttcc tcaccactcc ccaccgctac aactccaaaa      480

ccacttatcc ctacagaggc cagcatcagg gtctggtcag acttcctcag agtccatctc      540

catccccgga gcatctgtat gattcagaag tacaaccacg atggggaagc aggtcggctg      600

gaggcttttg gccaagggga aagtgtccta aaggaaccca agtaccagga agagctggag      660

gacaggctgc atttctacgt ggaggaatgt gactacttgc agggcttcca gatcctgtgt      720

gacctgcacg atggcttctc tggggtaggc gcgaaggcgg cagagctgct acaagatgaa      780

tattcagggc ggggaataat aacctggggc ctgctacctg gtccctacca tcgtggggag      840

gcccagagaa acatctatcg tctattaaac acagcttttg gtctcgtgca cctgactgct      900

cacagctctc ttgtctgccc cttgtccttg ggtgggagcc tgggcctgcg acccgagcca      960

cctgtcagct tcccttacct gcattatgat gccactctgc ccttccactg cagtgccatc     1020

ctggctacag ccctggacac agtcactgtt ccttatcgcc tgtgttcctc tccagtttcc     1080

atggttcatc tggctgacat gctgagcttc tgtgggaaaa aggtggtgac agcaggagca     1140

atcatccctt tccccttggc tccaggccag tcccttcctg attccctgat gcagtttgga     1200

ggagccaccc catggacccc actgtctgca tgtggggagc cttctggaac acgttgcttt     1260

gcccagtcag tggtgctgag gggtatagac agagcatgcc acacaagcca gctcacccca     1320

gggacacctc caccctctgc ccttcatgca tgtaccactg gggaagaaat cttggctcag     1380

tatttacaac agcagcagcc tggagtcatg agttcttccc atctgctgct gactccctgc     1440

agggtggctc ctccttaccc ccacctcttc tcaagctgca gtccaccggg tatggttctg     1500

gatggttccc ccaagggagc agcagtggag agcatcccag tgtttggggc actgtgttcc     1560

tcttcgtccc tgcaccagac cctggaagcc ttggccagag acctcaccaa actcgacttg     1620

cggcgctggg ccagcttcat ggatgctgga gtggagcacg atgacgtagc agagctgctg     1680

caggagctac aaagcctggc ccagtgctac cagggtggtg acagcctcgt ggactaaagt     1740

tcccagtgtg ggagaaagga gctagtttgc aataaaaaca gctggatgca ggagcccagt     1800

gtcttcatgc agaggagctc aatgtcgcgg gactagctac accaacatat gcacttttta     1860

catttagaaa cactgtgatt agaccacaga acaataaata tgtgccatca gaccaaaaaa     1920

aagtagagaa aggagctgaa ctccactctc gatgctactt acagaggaca tctgtaaagt     1980

cttcataaaa gaccttgaat gatgcctagg atggcagagc ccctgggtcc tactccatcc     2040

tccagccttt gtccttgtcc tggcctcctg ctctccagat ctgtaaactg ggctcaagga     2100

ctgtacaagc agagtacaac tacccgcctc cccggtgcca gggcgcctgt tgggtttggt     2160

cctgtgtaga tgattcccag agtctcattc atccagctcc tcttcagaca gaaggtcccc     2220

atggtcagac agctggtctg cattgctggt actggttgca tcatcctcat cctcagagct     2280

ggcttcacag gcagtgtgga agagctgcat gagttctcga aaatggtggg aaacctaaga     2340

aaggaggagg gctgtattca ctgatcctta gtaacatgtt aacatttatg aagcactata     2400

tattgatttg caaaatcttt tgtttattcc a                                    2431


<210> 276
<211> 2201
<212> DNA
<213> Homo sapiens

<400> 276
agagcaagga agggcagggg acctgggaag gaagttctgg aaggcagtgg ggtttgagat       60

tggacccagg gtcaagatag aacatgaagg tgggatgagg acatgaacag aacatggcca      120

agaaggatct gggggagcag ccaggacgag gcggagctga tccgagagga catccagggg      180

gctctgcaca attaccgctc gggccgcggg gagcgcaggg cggcggcgct cagggccacg      240

caggaggagt tgcagcgcga ccgctcgccc gccgctgaga ccccgcccct gcagcgccgc      300

ccgtcagtcc gcgcagtgat cagcaccgta gagcggggcg cgggccgcgg acgaccccag      360

gcgaagccca ttcccgaggc agaggaggcg cagaggcctg agccggtggg gacctcgagc      420

aacgctgact cggcctcccc ggacctgggt ccccggggtc ctgacctggc ggttctgcag      480

gcggagcggg aagtggacat cctgaaccac gtgttcgacg acgtagagag ctttgtatcg      540

aggctgcaga agtcggcgga ggcggccagg gtgctggagc accgggaacg cggccgcagg      600

agccggcgcc gggcggctgg ggagggcttg ctgacgctgc gggccaagcc gccctcggag      660

gccgagtaca ccgacgtgct gcagaagatc aagtacgcct tcagcctgct ggcccggctg      720

cgcggcaaca tcgccgaccc ctcctctccg gagctgttgc acttcctttt cgggcctctg      780

cagatgattg tgaacacgtc gggggggccg gagttcgcga gcagtgtgcg gcggccgcat      840

ctgacatcgg atgccgtggc gctgctgcgg gacaacgtca ctccacgtga aaacgagctc      900

tggacctcgc tgggggactc gtggacccgc cccgggctgg agctgtcccc ggaggaggga      960

cccccataca gacccgagtt cttcagcggc tgggagccgc cggtcactga cccgcagagc     1020

cgcgcctggg aggacccagt tgagaaacag ctacagcacg agcggaggcg ccggcagcaa     1080

agcgcccccc aggtcgctgt caatggtcac cgagacttgg agccagaatc tgagcctcag     1140

ctggagtcag agacagcagg aaaatgggtc ctgtgtaatt atgacttcca ggcccgcaac     1200

agcagtgagc tgtcggtcaa gcagcgggac gtactggagg tcctggatga cagtcgtaag     1260

tggtggaagg ttcgggaccc agcggggcag gagggatatg tgccctacaa catcctgaca     1320

ccctaccccg gaccccggct gcaccacagc caaagccctg cccgcagcct gaacagcact     1380

cctcctccac caccagcccc agccccggcc ccacctccag ctctggctcg gccccgctgg     1440

gacaggcccc gctgggacag ctgcgatagc ctcaacggct tggaccccag cgagaaggag     1500

aaattctccc agatgctcat cgtcaacgag gaactgcagg cgcgcctggc ccagggccgc     1560

tcgggaccga gccgcgcagt cccagggccc cgcgccccgg aaccgcagct cagcccgggc     1620

tcggacgcct ccgaggtccg cgcctggctg caggccaagg gctttagctc cgggaccgtg     1680

gacgcgctgg gtgtgctgac cggggcgcag cttttctcgc tgcagaagga ggagctgcgg     1740

gcggtgagcc ccgaggaggg ggcacgtgtg tacagccagg tcaccgtgca gcgctcgctg     1800

ctggaggaca aagagaaagt gtcagagctg gaggcagtga tggagaagca aaagaagaag     1860

gtggaaggcg aggtggaaat ggaggtcatt tgacctgcca ggcgcccttc gcaaagagtg     1920

acgaggcccc gtgggagaac ggactcctca gactctcccc aatagcggaa gtcgatcttc     1980

tgaaggatgg ccaatctgct ccggccctgg tcttccccca tcccggtgga cagacttaac     2040

gatccttgct gcagtccctc cggagaggat ctggactggc tgggagtggg gagggcgtgg     2100

agacagtcta cggaaagcgc tagcagaccc ccgagagggt gcagtggagc cctgagcatt     2160

gtaatatgcg gcccagccta taaacagcct ccgtgcttag c                         2201


<210> 277
<211> 2246
<212> DNA
<213> Homo sapiens

<400> 277
ccacccccgg ccccgaagct ccgccacccg ccgccatgag tagctttgga gctggcaaaa       60

ccaaagaagt tatcttcagt gtggaggatg gctccgtgaa aatgttcctg aggggccgcc      120

ctgtgcccat gatgatccca gacgagctgg cacccaccta cagcctggac acacgctcgg      180

agctgccttc ttgccggctc aagctggagt gggtctatgg ctaccgtggc cgagactgcc      240

gggccaacct ttatttgctg cccaccgggg agatagtgta ctttgtggcc tccgtagccg      300

tgctatacag cgtggaggag cagaggcagc gacactacct gggacacaac gatgacatca      360

aatgcttggc catccaccca gatatggtca ccatcgccac gggacaggtg gcgggaacca      420

ctaaggaagg gaagccgctg ccgccccacg tgcgcatctg ggactcagtt tccctctcca      480

ccttacacgt gctgggcttg ggggtgtttg acagagccgt gtgctgtgtg ggcttctcca      540

aatctaatgg aggcaacctg ctgtgtgcag tggatgaatc caatgatcac atgctctcgg      600

tgtgggactg ggccaaggag accaaggtgg tggatgtcaa gtgctccaat gaggctgtat      660

tggtggccac cttccacccc acggacccca ctgtgcttat cacctgcggg aaatctcaca      720

tctacttctg gaccttggag gggggcagct tgagcaagcg gcaaggcctc tttgagaaac      780

atgagaaacc gaagtatgtg ctgtgtgtga cctttttgga aggtggcgac gtggtcacgg      840

gggactctgg ggggaacctc tatgtttggg gcaaaggtgg gaaccgtatc acacaggcgg      900

tgctgggcgc ccacgacggc ggcgtgtttg ggctctgcgc cctgcgggac gggacgctgg      960

tgtctggagg gggccgtgat cggcgggtgg tcctctgggg ttctgactac agcaagctgc     1020

aggaagtgga ggtccctgag gactttggcc ctgtgcgcac cgtggcagag ggccacggag     1080

acacactgta cgtggggacc acccgcaatt ccatcctgca gggctccgtg cacacaggct     1140

tctcactgct ggtccagggc catgtggaag agctgtgggg cctggccaca caccccagtc     1200

gggcccagtt tgtgacctgc gggcaggata agctggtgca tctatggagc tcagattccc     1260

accagcccct gtggagcagg atcatcgagg accctgcccg ctcagccggc ttccacccca     1320

gtggctctgt cctggctgtg ggtacagtga ctggcagatg gctgctgctg gacacggaga     1380

cccatgacct ggtggctatc cacacagacg gcaatgaaca gatctcagtg gtcagcttct     1440

ccccagacgg ggcgtacctg gccgtgggct cccacgacaa cttggtgtac gtgtacacgg     1500

tggaccaggg cggccgcaag gtcagccgcc tgggcaagtg ctcgggccat tccagtttta     1560

tcacccacct ggattgggcc caggacagca gctgctttgt caccaactcc ggggactatg     1620

agattctgta ctgggacccg gctacctgta agcagatcac cagtgcggat gctgtgagga     1680

acatggaatg ggccacagct acttgtgtcc tagggtttgg ggtgtttggg atctggtctg     1740

agggggcgga cggcactgat atcaacgctg tggcccgctc tcatgatggg aagttgctgg     1800

cttcagctga tgactttggc aaagttcacc tgtttagcta cccctgctgt cagcctcgag     1860

ccctcagcca caagtacggt ggacacagca gccatgtgac aaatgtggcc ttcttgtggg     1920

atgacagcat ggccctgacc acagggggca aggacaccag tgtgctacag tggcgggtgg     1980

tctgatgcgg ccagggaaga gtcaggtgtc agggcaggaa ttctattttc gggagatgtc     2040

tattgccgag tagagtaata tatacccaga gtatgtctat agcagagggg gttatggggg     2100

cgggagggta gactgacata cagaagtctc tatttatccg ggtgggaaga gggagtcaca     2160

tcgctttggg gatccattgg tgtttggttt ggggtgtttt ttaagttttt tcttttatat     2220

catccagaaa taaagacacg tacact                                          2246


<210> 278
<211> 2042
<212> DNA
<213> Homo sapiens

<400> 278
ttccggcttc cccgccccgc cccgtccccg ggcgtctcca ttttggtctc aggtgtggac       60

tcggcaagaa ccagcgcaag agggaagcag agttatagct accccggccg cggagccggc      120

tcactgcact acccccgccc ccttctttcc tccagacgcc gaagtcgcgg gcgctcatgg      180

cgggcctgga ggtactgttc gcatcggcag cgccggccat cacctgcagg caggacgcgc      240

tcgtctgctt cttgcattgg gaagtggtga cacacggtta cttcggcttg ggtgtcggtg      300

accagccggg tcccaatgat aagaagtcag aactgctgcc agctgggtgg aacaacaata      360

aagacctgta tgtcctccgg tatgagtata aggatgggtc cagaaagctc cttgtgaaag      420

ccatcaccgt ggagagcagc atgatcctca atgtgctgga atatggctca cagcaagtgg      480

cagacttgac cctgaacttg gatgattata tcgatgcaga acacctgggt gacttccaca      540

ggacctacaa gaacagtgag gagcttcggt ctcgtattgt gtctggaatc atcacaccta      600

tccatgagca gtgggaaaag gctaatgtaa gcagtcccca ccgggagttc ccccctgcta      660

ccgccagaga ggtggaccca ctccggattc ctccacacca cccacacacc agtcggcagc      720

ctccctggtg tgatcccctg ggcccgtttg ttgtcggggg agaagactta gacccttttg      780

ggcctcggag aggtggcatg attgtggatc ccctgagatc tggcttccca agagcactta      840

ttgacccttc ctcaggcctc ccgaaccgac ttcctccagg cgctgtgccc ccaggagctc      900

gctttgaccc ctttggaccc attgggacca gcccacccgg cccgaggcct gacagacgcg      960

ggcagtgatg agccctgttc tggagtggaa agagcacgat agagcaccag gctaagaggc     1020

acgagatcaa ggcggtagtc acttccgctc tgcagctagc atttcaacca tatgtggatc     1080

ctttcatttc tcagctccct ggattccttc ccctaaatta ggacctatta tttacctgta     1140

ggtaagcaag ctactgtagc tcttctgagg tatctgccag gctgttttct gtagcctcag     1200

attgcctatc tgcttagcct gagaacaggt agatgaaaac taaactgatg cctaggccca     1260

gggtcagtct cagatggaag ctgggcctgg gtggggaggc tagcatgcgt ggctccctgg     1320

gtatttctgt cagtccccat ggcaagcagt gatttagtaa aacaccccag agtcagggaa     1380

gccaaccacc ttgaaacctt tagaacatct ctgctttgga gaaagaccca gagatcaggc     1440

agaggtgcag attcaatcat tactcataac ctttgagaga tggcaaatgg gaggagtgtt     1500

agtctttgtt ttggaattgg accattcttg caaccaaaag gacttagagc agtttgctca     1560

taaagacatc ctttattata aaaggaagta tttaaaggat gatagagacc atcagataga     1620

agcagggaag gtagataact tttaggacct tgatgtgagg aaaagataaa atttaaacaa     1680

taaatttgcc acttagattt tctagcagca aagtccgaaa agatagttat atacaaaatt     1740

ctgttttctg aaaacaaaat tgtgattcac cttcagaatt ggccattttt tttgtgagtt     1800

tccttgcatc aaggacactg agaaacacag tcattgtctt aggtgttcta tgggaggaag     1860

tgaatagagc ctttaggaac ttcctggtca agcttatggt gcttattttg atctgggcca     1920

cttccctcct tccagtcatg agtaatcatc aaggagcaag ttggagtgtt tcaggtgtat     1980

attttgtaga acccaaaaga ttggagcctt aacaataaac atcagcacta agtgacctgt     2040

tc                                                                    2042


<210> 279
<211> 595
<212> DNA
<213> Homo sapiens

<400> 279
gggcctaaga cataagctga acctctggcc tgcagttcca gatccaaggt gactgagaca       60

aactgccagc tgccactggc ttatcaggag cacctgaatc tgctgacaca tcaaggccac      120

ttttcttagg agccccctga cttccaaaat cagtgccttt ggattcatct cttccgggag      180

agttcagtgt cttctgaaat gttacaaaac gtccttcaga gcaagaaggc gtacacgagg      240

agctcgactc tgtagaaagg agatggacaa catgtctccc aggctgagag ccttcctctc      300

cgaacccatt ggagaaaagg atgtctgctg ggtggatggc atcagccatg agctcgcgat      360

caatttggtc accaaaggta tcaataaggc ctacatcctg ctgggacaat tccttctgat      420

gcacaagaat gaagccgagt ttcagaggtg gctcatttgc tgttttggtg ccactgagtg      480

tgaggcccag cagacttctc actgcctcaa ggagtggtgt gcctgcttcc tgtagacaca      540

aacctcattg ctgcccccca ccaccctctg gggaaaatga cgccttctcc accta           595


<210> 280
<211> 1619
<212> DNA
<213> Homo sapiens

<400> 280
ctttacaagt atgaactcat ttaattccct caactctgtg atataagcag tggccggtgt       60

ccagctgcct actttctgcc cggatctctg gctcctcatc tctccggtct ccgcagacta      120

aagccctcgg gatatgcagc agccatgcct gtgcacacgc tgagccccgg agccccgtcc      180

gcccccgccc taccttgccg cctgcggacc agggtccctg gctacctgct acgggggccg      240

gcagatggtg gagcccggaa accgagcgct gtggagcgcc tggaggccga caaggccaag      300

tacgtcaaga gcctgcacgt ggccaacacc cgccaggagc ctgtgcagcc cctgctgtcc      360

aaacagccgc tctttagccc tgagactcgc cgcacagtgc tcacgcccag ccgccgagcc      420

ctgcctggcc cctgccgacg gccccagctg gacctggaca tcctcagcag cctcatcgac      480

ttgtgtgaca gccccgtgtc ccctgccgag gccagccgca ctcctggacg ggccgaggga      540

gccggccgtc ctcccccagc cacccctccg cgaccgccgc ccagtacctc tgcggtccgc      600

cgggtggacg tccgccccct gcccgcctcg cctgcccggc cctgcccatc acccggccct      660

gccgccgcct ccagcccagc ccggccgccg ggtttgcaac gctccaagtc ggacttgagc      720

gagcgctttt ctagggcagc cgctgatctc gagcgctttt ttaacttctg cggcctggac      780

ccggaggagg cgagagggtt gggtgtggcc cacctggcac gggccagctc ggatatcgtg      840

tccctggcag ggcccagtgc tgggccgggc agctctgaag ggggctgctc ccgccgcagc      900

tcggtgactg ttgaggagcg ggcccgggag cgcgttccct atggcgtgtc ggtggtggag      960

cgcaatgccc gcgtgatcaa gtggttgtat gggctaaggc aggctcggga gagcccagca     1020

gctgaaggct aggcgccact gggcctggaa ttcgccacag gacggatctt acagaggcaa     1080

gtggtccctg gacctctctt gcatccattc tctagacggc cgtgtcagag gctccaccct     1140

gttgtgaact tggtatggag gcaaaggctt agaggctgga ccagcattgt tgggcaagga     1200

ctgactctcc aagggttttg ttcttggctt tggacacctg agaaccccct cctcccctcc     1260

cccaatacaa ggtttttgac atgagtgtac tcctgcttag ttcctcttgt ggggctgcat     1320

ttgcggtgct ttgccctccc cactgtgagt gaggggccaa gggatctcct caatcctgtc     1380

tccccagcgg ctctgtttcc tccttccttc cttggcctct gtcctttgct gacttcctct     1440

tccttaccca gcagaactca ccctggggtc ggggcagtgg ggaggggcct atccactgct     1500

cttcctagtc cttggcagct ggcctaggtg ggcagactat aggagggact ggttaggagt     1560

ctgcattgct ttgacttccc tctccttggt taataaacac aaatgcttgt ttctcaagg      1619


<210> 281
<211> 1231
<212> DNA
<213> Homo sapiens

<400> 281
acgagccagg acatgtgcta ataatgccct aagccggtta taaagacgtg gaaattgagg       60

ggagaaaaaa aaagggaaaa aaagggtctg tccttcctgg gattcctagc cgaggccagt      120

ctgctgccgt gtgcgtgtgc gtcagggctc tccgggcggc aatgggggct tgagagccgg      180

gtccccagcg ccgggaaggg agcgcggtgg ccgccaccgc caccgccccg gagtccggcg      240

ccgaagctgc gggcgggcgg gcgggcacca gctcggtcag gggctgcttg gcgcggcact      300

gtgcggtgca gcggcggcgc ggcgcggtgc gggcttttcc caggcgcccc ggggtcgggt      360

ggccaacggc gcggccgcgg gcgctgagcg cgaccggttc gcggtagcgg tggcggcggc      420

gtgcgtgcca ggggctgggg gctccgccgc ctctcttgcg gctcaccgag ctccgcgctt      480

ccctctctcc agggcaggcg gcttctcaga gcacaacagc tccagctggc agcatcactt      540

cccgccaatt tatccaactt ctgccaaggc tctgaaatgc caacaacgtc gaggcctgca      600

cttgatgtca agggtggcac ctcacctgcg aaggaggatg ccaaccaaga gatgagctcc      660

gtggcctact ccaaccttgc ggtgaaagat cgcaaagcag tggccattct gcactaccct      720

ggggtagcct caaatggaac caaggccagt ggggctccca ctagttcctc gggatctcca      780

ataggctctc ctacaaccac ccctcccact aaacccccat ccttcaacct gcaccccgcc      840

cctcacttgc tggctagtat gcacctgcag aaacttaata gccagtatca ggggatggct      900

gctgccactc caggccaacc cggggaggca ggacccctgc aaaactggga ctttggggcc      960

caggcgggag gggcagaatc actctctcct tctgctggtg cccagagccc tgctatcatc     1020

gattcggacc cagtggatga ggaagtgctg atgtcgctgg tggtggaact ggggttggac     1080

cgagccaatg agcttccgga gctgtggctg gggcagaatg agtttgactt cactgcggac     1140

tttccatcta gctgctaatg ccaagtgtcc ctaaagatgg aggaataaag ccaccaattc     1200

tgttgtaaat aaaaataaag ttacttacaa a                                    1231


<210> 282
<211> 1155
<212> DNA
<213> Homo sapiens

<400> 282
tagtttgcgt tttcacctgg tcgcccggcg gccatggcgg ccgttctgaa gccggtgctg       60

ctgggccttc gagatgcgcc ggtgcacggc agccccacag ggccgggtgc ctggactgct      120

agcaagctgg gcggcattcc ggatgctctg cccaccgtgg ctgcgcccag gcccgtgtgt      180

cagcgctgcg ggcagccgct cgctctggtc gtgcaggtgt attgcccgct ggaaggctcc      240

ccgtttcacc gtctgctgca cgtgttcgcg tgcgcctgcc ccggctgtag caccggcggt      300

gcgcgcagct ggaaggtgtt ccgctcccag tgcctgcagg tgccagagag agaggcgcag      360

gacgctcaga aacagggaaa cagccttgca gctgaggact ggtgtgaagg tgctgatgac      420

tggggaagtg atactgagga ggggccttca ccacagttta ccttggattt tgggaatgat      480

gccagcagtg ccaaagacgt agactggact gctcggctcc aagacctccg cctgcaggat      540

gctgtcctgg gtgctgccca tcctgtgcct cctgggctgc cgctcttcct gccctactac      600

atctgtgttg cagatgagga tgattacagg gactttgtca acctggatca tgcccacagc      660

cttctgaggg actatcagca gagagaaggc attgccatgg atcagttgct ttcccaaagc      720

cttcctaatg atggtgatga aaaatatgag aagaccataa ttaaaagtgg agatcagacg      780

ttttacaaat tcatgaagcg aattgctgct tgtcaggagc agattttgag gtattcctgg      840

agtggagagc cactcttttt gacctgccct acatcagaag tcaccgagct cccagcctgc      900

agccagtgtg gaggccaaag gatatttgag tttcagctta tgccagcact ggtcagcatg      960

ctcaagagtg ctaatttagg tctttctgtg gaatttggaa caattctagt ttacacatgt     1020

gagaagagtt gctggccccc aaatcatcag actcccatgg aagaattttg tattatacaa     1080

gaagacccag atgaattatt gtttaagtag agcatttcct tttattaata taaattaaaa     1140

caaatgttta catcc                                                      1155


<210> 283
<211> 1833
<212> DNA
<213> Homo sapiens

<400> 283
gaggaaggag cccctccctg ggagccagac ccccacacca tggcgagcgt ggtggtgaag       60

acgatctggc agtccaaaga gatccatgag gccggggaca cccccacggg ggtggagagc      120

tgctcccagc tagtcccaga ggctccccgg agggtgacca gccgggccaa ggggatcccg      180

aagaaaaaga aggccgtgtc gttccacggg gtggagcccc agatgtccca tcagcccatg      240

cactggtgcc tgaacctcaa acggtcctcg gcctgcacca acgtgtcact gctcaacctg      300

gccgccatgg agcccactga ctccacgggg acagactcca cagtggaaga cctcagcggc      360

caactcacac tggctgggcc ccctgcctcc cctaccctac cctgggatcc ggatgacgca      420

gacatcacgg aaatcctgag tggggtcaac agtggattgg tccgcgccaa agactccatc      480

accagcttga aggaaaagac caaccgggtt aaccagcacg tgcagtctct gcagagcgag      540

tgttctgtgc tgagcgagaa tctggagaga aggcggcaag aggcagaaga gttggagggg      600

tactgcattc aactcaagga gaactgctgg aaggtgaccc ggtctgtgga agatgctgaa      660

atcaaaacca acgtcttgaa gcagaattct gccctgctgg aggagaagct gcgctacctc      720

cagcagcagc tgcaggatga gacgccgcga cggcaggagg ccgagctgca ggagccggag      780

gagaagcagg agccggagga gaagcaggag ccggaggaga agcagaagcc ggaggctggc      840

ctctcctgga acagcctggg ccccgccgcc acgtcccagg gctgccccgg cccgccaggg      900

agtcccgaca aaccctcgcg gccacacggc ctggtccccg caggctgggg aatggggcct      960

cgggctggcg agggccccta cgtgagcgag caggaattgc agaagctgtt caccggcatc     1020

gaagagctga ggagagaggt gtcctcactg accgcccggt ggcatcagga ggagggggcg     1080

gtgcaggaag ccctgcggct gctcgggggc ctgggcggca gggtcgacgg cttcctaggc     1140

cagtgggagc gggcacagcg cgaacaggca cagacggcgc gggacttgca ggagctgcga     1200

ggtcgggcgg atgagctgtg caccatggtg gagcggtcag cagtgtctgt ggcttcactg     1260

aggagcgaac tggaggggct gggcccactg aaacccattc tggaggagtt cgggcggcaa     1320

tttcagaact ctcgaagagg gcctgacctc tccatgaacc tggatcggtc ccaccaaggc     1380

aactgtgccc gctgtgccag ccaggggtcg cagttgtcta cggagtccct gcagcagctg     1440

ctggaccgag cactgacctc actagtggac gaggtgaagc agaggggcct gactcctgcc     1500

tgtcccagct gtcagaggct acacaagaag attctggagc tggagcgcca ggccttagcc     1560

aaacacgtca gggcagaggc cctgagctcc acccttcggc tggcccaaga cgaggccctg     1620

cgggccaaga acctactgct gacagacaag atgaagccag aggagaagat ggccactctg     1680

gaccatctac acttgaagat gtgctccctc cacgatcatc tcagcaacct gccacttgag     1740

gggtccacgg gaacaatggg gggaggcagc agtgcaggaa cccccccaaa acaggggggc     1800

tcagcccctg aacaataaat ggcctctcat gct                                  1833


<210> 284
<211> 2973
<212> DNA
<213> Homo sapiens

<400> 284
agcaaaccaa tcgcaagcct cgttgagtgg aaggggtggg atcttccccg gaagtgttgg       60

ttaaagcccc tccaatcagc ggctcggtgc ggcaagtttg aatttcgtgg aggctcgggt      120

tgtgagggtt cctgcttcgg agtcggcggt ggtcgtccag accgagtgtt ctttactttt      180

tgtttggttg aggtttcacg ctagaaggtg gctcaggatg tcttcatcac attttgccag      240

tcgacacagg aaggatataa gtactgaaat gattagaact aaaattgctc ataggaaatc      300

actgtctcag aaagaaaata gacataagga atacgaacga aatagacact ttggtttgaa      360

agatgtaaac attccaacct tggaaggtag aattcttgtt gaattagatg agacatctca      420

agggcttgtt ccagaaaaga ccaatgttaa gccaagggca atgaaaacta ttctaggtga      480

tcaacgaaaa cagatgctcc aaaaatacaa agaagaaaag caacttcaaa aattgaaaga      540

gcagagagag aaagctaaac gaggaatatt taaagtgggt cgttatagac ctgatatgcc      600

ttgttttctt ttatcaaacc agaatgctgt gaaagctgag ccaaaaaagg ctattccatc      660

ttctgtacgg attacaaggt caaaggccaa agaccaaatg gagcagacta agattgataa      720

cgagagtgat gttcgagcaa tccgacctgg tccaagacaa acttctgaaa agaaagtgtc      780

agacaaagag aaaaaagttg tgcagcctgt aatgcccacg tcgttgagaa tgactcgatc      840

agctactcaa gcagcaaagc aggttcccag aacagtctca tctaccacag caagaaagcc      900

agtcacaaga gctgctaatg aaaacgaacc agaaggaaag gtgccaagta aaggaagacc      960

tgccaaaaat gtagaaacaa aacccgacaa gggtatttct tgtaaagtcg atagtgaaga     1020

aaatactttg aattcacaaa ctaatgcaac aagtggaatg aatccagatg gagtcttatc     1080

aaaaatggaa aacttacctg agataaatac tgcaaaaata aaagggaaga attcctttgc     1140

acctaaggat tttatgtttc agccactgga tggtctgaag acctatcaag taacacctat     1200

gactcccaga agtgccaatg cttttttgac acccagttac acctggactc ctttaaaaac     1260

agaagttgat gagtctcaag caacaaaaga aattttggca caaaaatgta aaacttactc     1320

taccaagaca atacagcaag attcaaataa attgccatgt cctttgggtc ctctaactgt     1380

ttggcatgaa gaacatgttt taaataaaaa tgaagctact actaaaaatt taaatggcct     1440

tccaataaaa gaagtcccat cacttgaaag aaatgaaggt cgaattgctc agccccacca     1500

tggtgtgcca tatttcagaa atatcctcca gtcagaaact gagaaattaa cttcacattg     1560

cttcgagtgg gacaggaaac ttgaattgga cattccagat gatgctaaag atcttattcg     1620

cacagcagtt ggtcaaacaa gactccttat gaaggaaagg tttaaacagt ttgaaggact     1680

ggttgatgat tgtgaatata aacgaggtat aaaggagact acctgtacag atctggatgg     1740

attttgggat atggttagtt ttcagataga agatgtaatc cacaaattca acaatctgat     1800

caaacttgag gaatctgggt ggcaagtcaa taataatatg aatcataata tgaacaaaaa     1860

tgtctttagg aaaaaagttg tctcaggtat agcaagtaaa ccaaaacagg atgatgctgg     1920

aagaattgca gcgagaaatc gcctagctgc cataaaaaat gcaatgagag agagaattag     1980

gcaggaagaa tgtgctgaaa cagcagtttc tgtgatacca aaggaagttg ataaaatagt     2040

gttcgatgct ggatttttca gagttgaaag tcctgttaaa ttattctcag gactttctgt     2100

ctcttctgaa ggcccttctc aaagacttgg aacacctaag tctgtcaaca aagctgtatc     2160

tcagagtaga aatgagatgg gcattccaca acaaactaca tcaccagaaa atgccggtcc     2220

tcagaatacg aaaagtgaac atgtgaagaa gactttgttt ttgagtattc ctgaaagcag     2280

gagcagcata gaagatgctc agtgtcctgg attaccagat ttaattgaag aaaatcatgt     2340

tgtaaataag acagacttga aggtggattg tttatccagt gagagaatga gtttgcctct     2400

tcttgctggt ggagtagcag atgatattaa tactaacaaa aaagaaggaa tttcagatgt     2460

tgtggaagga atggaactga attcttcaat tacatcacag gatgttttga tgagtagccc     2520

tgaaaaaaat acagcttcac aaaatagcat cttagaagaa ggggaaacta aaatttctca     2580

gtcagaacta tttgataata aaagtctcac tactgaatgc caccttcttg attcaccagg     2640

tctaaactgc agtaatccat ttactcagct ggagaggaga catcaagaac atgccagaca     2700

catttctttt ggtggtaacc tgattacttt ttcacctcta caaccaggag aattttgaat     2760

ttaaaaataa atccaaacat tttccttcat attatcaatg cttatatatt ccttagacta     2820

ttgaaatttt ggagaaaatg tatttgtgtt cacttctata gcatataatg ttttaatatt     2880

ctgtgttcat caaagtgtat tttagatata ctctttctca agggaagtgg ggatattttg     2940

tacattttca acacagaata aaaaatgtac tgt                                  2973


<210> 285
<211> 2037
<212> DNA
<213> Homo sapiens

<400> 285
acgcttctct cgcgccctct gcaggaacct gggccgaggg ccgccccgcc tcgctgcccc       60

caggctcata aatggcctct gcgccctggc cggagcgggt tccgaggctg ctcgctccgc      120

gcttaccctc ttacccgccc ccacccccaa cagtgggatt acggtccatg gagcaggagg      180

agacctacct ggagctctac ctggaccagt gcgccgctca ggatggcctt gccccaccca      240

ggtctcccct gttcagccca gttgtacctt atgatatgta catactgaat gcatccaatc      300

cggatactgc atttaattcg aaccctgaag tcaaagaaac atctggtgat ttctcatctg      360

tggatcttag cttcctacca gatgaagtta cccaggaaaa taaagaccag cctgtcatta      420

gcaaacacga aactgaagaa aattctgaaa gccaaagtcc acaaagtagg ttgccatcac      480

ccagcgaaca ggacgttggg ctgggcttaa acagcagcag tttgtcaaat tcccattcac      540

agctgcaccc tggtgatact gactcagtcc agccctctcc tgagaaacca aactccgact      600

ccttgtctct ggcatccata actcccatga caccaatgac ccctatttca gaatgttgtg      660

gaattgtacc tcaactacag aatatagttt ccactgtaaa cctggcctgt aagttggatc      720

tgaagaaaat agctttgcat gcaaaaaatg cagaatataa cccaaagagg tttgctgctg      780

tcataatgag gatccgagag cccaggacaa cagcccttat atttagctct gggaagatgg      840

tctgcacggg agccaaaagt gaagagcagt ctcgacttgc agcaagaaaa tatgctcgtg      900

tggtgcagaa gcttgggttc cctgccagat tcctcgattt taaaattcag aacatggttg      960

gaagctgtga tgtgagattt cccatcaggc tggaaggttt ggtgctaacc catcagcagt     1020

tcagtagtta cgagcctgaa ctgtttcctg gtcttattta tagaatggta aaaccacgaa     1080

ttgtgttgct tatctttgta tctggaaaag ttgtgttgac aggtgccaaa gaacgttctg     1140

agatctatga agcatttgaa aacatctatc ctattctaaa aggttttaaa aaagcctgag     1200

catatcattc agcatctcac attattctgg tttgaatatg tccataagcc cagcacagaa     1260

acagctggat tcttctacgt ttaattgtag atgttacaag tacgttactt attaaagggc     1320

gactctgtgt aagtaaccta agaaacgaag aaaaattctt attcaaaatg actccttttg     1380

tgttatttta aaaactgaac aagtaaacat ttcaaaattt gagagattta gggtctcact     1440

agaatgatat tgtagcatca tgaagactca atgcgtttcc ttttagccgg aagggccatc     1500

ttccagtaat ttgccaaaat gacgaacaca aagggaaaga ggtgaggcac ctgatacatg     1560

ttctctaggc cttttagaaa agatggagtt gttcctttgg ccacatacat gcgaatctac     1620

gaaaaaggtg atattgtaga catcaaggga atggctgctt ttcaaaaagg agtgctccgc     1680

aaatgttacc acagcaaagc tggaagagtc tacagtgtta cccagcatgc tgttggcatt     1740

gtaaacaagg gcaagatttt tgccaagaga atgaatgtgc ttactgagcc aggctggtct     1800

tgaactcctg acctcagttg atccatctgc ctgggccttg gcactctaag agccaagtaa     1860

gtttcctgaa acgcgtgaag gtaaataatc agaaaaagac gtcaaaggga gaggtgtctg     1920

agttcaactg aagcgccagc ctgctccacc cagacaagca cttagaacca atggagggag     1980

cctgggctgc tggaacctat tccctatgag ttcatggcat aataggtgtc aaaaaaa        2037


<210> 286
<211> 993
<212> DNA
<213> Homo sapiens

<400> 286
tctgcctccg catcctcgtg ggccctgacc ttctctctga gagccgggca gaggctccgg       60

agccatgcag gccgaaggcc agggcacagg gggttcgacg ggcgatgctg atggcccagg      120

aggccctggc attcctgatg gcccaggggg caatgctggc ggcccaggag aggcgggtgc      180

cacgggcggc agaggtcccc ggggcgcagg ggcagcaagg gcctcggggc cgagaggagg      240

cgccccgcgg ggtccgcatg gcggtgccgc ttctgcgcag gatggaaggt gcccctgcgg      300

ggccaggagg ccggacagcc gcctgcttca gttgcacatc acgatgcctt tctcgtcgcc      360

catggaagcg gagctggtcc gcaggatcct gtcccgggat gccgcacctc tcccccgacc      420

aggggcggtt ctgaaggact tcaccgtgtc cggcaaccta ctgtttatgt cagttcggga      480

ccaggacagg gaaggcgctg ggcggatgag ggtggtgggt tgggggctgg gatccgcctc      540

cccggagggg cagaaagcta gagatctcag aacacccaaa cacaaggtct cagaacagag      600

acctggtaca ccaggcccgc cgccacccga gggagcccag ggagatgggt gcagaggtgt      660

cgcctttaat gtgatgttct ctgcccctca catttagccg actgactgct gcagaccacc      720

gccaactgca gctctccatc agctcctgtc tccagcagct ttccctgttg atgtggatca      780

cgcagtgctt tctgcccgtg tttttggctc aggctccctc agggcagagg cgctaagccc      840

agcctggcgc cccttcctag gtcatgcctc ctcccctagg gaatggtccc agcacgagtg      900

gccagttcat tgtgggggcc tgattgtttg tcgctggagg aggacggctt acatgtttgt      960

ttctgtagaa aataaagctg agctacgatt ccg                                   993


<210> 287
<211> 2475
<212> DNA
<213> Homo sapiens

<400> 287
gtggggccat ggtggtcttg cgggcgggga agaagacctt tctcccccct ctctgccgcg       60

ccttcgcctg ccgcggctgt caactcgctc cggagcgcgg cgccgagcgc agggatacgg      120

cgcccagcgg ggtctcaaga ttctgccctc caagaaagtc ttgccatgat tggataggac      180

ccccagataa atattcaaac cttcgacctg ttcactttta catacctgaa aatgaatctc      240

cattggaaca aaagcttaga aaattaagac aagaaacaca agaatggaat caacagttct      300

gggcaaacca gaatttgact tttagtaagg aaaaagaaga atttattcac tcaagactaa      360

aaactaaagg cctgggcctg agaactgaat caggtcagaa agcaacattg aatgcagaag      420

aaatggcgga cttctacaag gaatttttaa gtaaaaattt tcagaagcac atgtattata      480

acagagattg gtacaagcgc aattttgcca tcaccttctt catgggaaaa gtggccctgg      540

aaaggatttg gaacaagctt aaacagaaac aaaagaagag gagcaactag gagtccactc      600

tgacccagcc agagtccagg tttccacagg aagcagatgg agctcctttc acaggggctc      660

tgagaaaaac tggagctgat ctcaagaagc cccacatctt cctaaggggc cccatggcct      720

gtttgggggc agggtaggtc ctggggcact gtgggccgcc tgcctgctga tgtgggctct      780

aggccagctt gttgtcacgt acgtggtgtg aaataaagcc caagcactgg gtgcccgttt      840

cctgtgtttc gaattatacc aattcaaaac agaactattt aaaaatattg gccaggcacg      900

gtggctcaca cctgtaatcc cagcactttg ggaggccgag gcgggtggat cacttgagat      960

caggagttca agatcagtct ggacaacatg gcaaaaccct gtctctacaa aaaattagct     1020

gggtgtggtg gcacgcacct gtaatcccag ctgctctgga ggctgaggca tgcgacgctt     1080

gaacccagga ggcggaggtt gcagtgatcc aagatcgcac cactgcactc cagcctggaa     1140

gaccaaacga gactctgtat caaaaaataa taataattaa taaagtttta ctggaaaaaa     1200

gaagtctgct gacgggaatg atgtggaagc tgactgccaa gcgatcggtg tgctggccgt     1260

ggagtcagca ccaccctcac tgtgagtcgt cagctggtgg gtcctcacag gctgcgtcct     1320

gaatgcagtg cggtgtgagg acatgaaagc aaatgcaatt ttattgcatg ccaaaaagtt     1380

taacttgatt cttggtgtta actatgttag tagattcttc aatgctataa gcaaattaac     1440

aagaaacagc agcactattt tcctcttttc ttaaacacga aggttaaatg gccaggcatg     1500

gtgactcata cctgtaatcc caacaatttg ggaggccaag gcaagcaaat cacttgagct     1560

caggagttcg aaccagtttg ggcaacatgg cgaaaccctg cctctacaaa acatgcaaaa     1620

attagctggg catggtagca tgcgcctgta gtcccagcta ctcgggaggc tgagcttcga     1680

ggattgattg agccagtgag gtccaggctg cactaagcca agatcctacc actaggcaac     1740

agagccagac cctgtctcaa ataaaaattt aaaaaaataa taaaaaaggc cgggcgcact     1800

ggctcacgcc tgtaatctca gcactttggg tggccaaggt gggcggatca cctgaggtca     1860

gttcaagacc agcctggcca aacatggtga aaccctgtct acaaaaatta gccaggcatg     1920

atggagggtg cctttagtcc cagctctttg ggaagctgag gcgggagaat agcatgaacc     1980

agggaggtgg agggtgcctg taatcccagc tccttgggag gctaaggcag gagaatagca     2040

tgaacccggt aggtggaggt tgcagtgagc cgagatcgcg ccactgcact ccagcctggg     2100

cgacagagca atactcccgt ctcaaaaaaa aaaaaattaa atgattgtga tatgtgttac     2160

ttttggtcac aaataaattg taattaagat tattctggcc aggtgcggtg gctcacgcct     2220

ataatcccag cactttggga ggccgaggtg ggcagatcat gaggtcagga gatcgagacc     2280

atcctgccca acatggtgaa accccgtttc tactaaaaat gcaaaaatta gctgggtgtg     2340

gtggcgtgtg cctgtaatgc cagctactcg ggaggctgag gcacgagaat cacttgaacc     2400

cagcaggcag aggttgcagt gagccaagat tgcgccactg cactccagcc tgacgacaaa     2460

gcgagactcc gtctc                                                      2475


<210> 288
<211> 3690
<212> DNA
<213> Homo sapiens

<400> 288
gggccagggc cgtgacacct gcgacgagcc ccgcctggcg ccagggggcg cggaagcgcg       60

tccgccccca ggccccatgc cgggctcgcc ccgcccctgc cggccacacc cccctacccc      120

gccctccctc cgtgaggacc ggccgctccc ggctcccggc ccccggcccc gcttccggcg      180

caggcgcagt cccgcgttcc ctcggcggct gccggcgtag tgagcccgcc gccgtggagt      240

gtagcggaaa gggctcgccg tcctcctccg tttctcgctg cttcgggacg cgctctctgc      300

ggctctgtga gcgcccctga gcgccggcag cggccgcggt gggttcttca ggttatctta      360

tgatgaggct tttgctatgg ctaatgatcc cttggaaggc ttccatgaag taaaccttgc      420

ttcacctact tctccggacc ttcttggtgt gtatgaatca ggaactcaag agcagactac      480

ctcaccaagt gtcatctacc ggccacaccc ttcagcttta tcctctgtac ctatccaggc      540

aaatgcatta gatgtttctg aacttcctac acaacccgtg tattcatccc ccagacgttt      600

aaattgtgcg gaaatatcta gtatcagctt tcatgttaca gacccagccc cttgctctac      660

ctctggagtc acagctggat taactaaatt aactacaaga aaggacaact ataatgcaga      720

gagagagttt ttacagggtg ctactataac agaggcttgc gatggcagtg atgatatttt      780

tgggttgagt actgatagtc tgtctcgttt acgaagccca tctgttttgg aagttagaga      840

aaagggctat gaacgattaa aagaagaact cgcaaaagct cagagggaac tgaagttaaa      900

agatgaagaa tgtgagaggc tttcaaaagt gcgagatcaa cttggacagg aattggaaga      960

actcacagct agtctatttg aggaagctca taaaatggtg agagaagcaa atatcaagca     1020

ggcaacagca gaaaaacagc taaaagaagc acaaggaaaa attgatgtac ttcaagctga     1080

agtagctgca ttgaagacac ttgtattgtc cagttctcca acatcaccta cgcaggagcc     1140

tttgccaggt ggaaagacac cttttaaaaa ggggcataca agaaataaaa gcacaagcag     1200

tgctatgagt ggcagtcatc aggacctcag tgtgatacag ccaattgtaa aagactgcaa     1260

agaggctgac ttatccttgt ataatgaatt ccgattgtgg aaggatgagc ccacaatgga     1320

caggacgtgt cctttcttag acaaaatcta ccaggaagat atctttccat gtttaacatt     1380

ctcaaaaagt gagttggctt cagctgttct ggaggctgtg gaaaacaata ctctaagcat     1440

tgaaccagtg ggattacaac ctatccggtt tgtgaaagct tctgcagttg aatgcggagg     1500

accaaaaaaa tgtgctctca ctggccagag taagtcctgt aaacacagaa ttaaattagg     1560

ggactcaagc aactattatt atatttctcc tttttgcaga tacaggatca cttctgtatg     1620

taactttttt acatacattc gatacattca gcagggactc gtgaaacagc aggatgttga     1680

tcagatgttt tgggaggtta tgcagttgag aaaagagatg tcattggcaa agctgggtta     1740

tttcaaagag gaactctgat gctctgcgtg ggaccatgcc tgaactcccc gaataactga     1800

aaaatggctg aatattttta tggttacttg atatttattt ccaaggagtg agcctaagac     1860

ttttttcccc ttttgcaaat tgctctaaga agtaccatga tttcttttaa actgatctat     1920

gctgtgtttg cttattcttt agttgaacac actatgaaga attccaggtg tactagtgaa     1980

tgtaatttat agttgccaaa aaaaaaaaaa acctgaaata aataaatgtt agattgaatg     2040

tgtgtacatt ttctcttcta gctctgacat ggcatttagg gttagcagaa tgtattaaat     2100

agtaattttc aaactacaca gtagcttcct tccttgtgag aggcaagaaa gaagtctgag     2160

tggatagtac tcactttcca aggcccccac ctctagaatg gctttatttt tatctgtttt     2220

ctatattggg tttcaaaaaa gattttattt gaagaaatac ttctgctgct acaaagtttg     2280

aaagttacta ttttaattat tctgctctct gtaactgaaa gaatcccttt attttggtta     2340

ttcattaaaa tataatagaa ggcagtcaga ttttatccca gagatgtatt cctgagtgtc     2400

ttgatatagt gtattcatgt tttatatgtg ttgaccacta tattgtcatt ggagggacat     2460

agatgtaaat gagtttgacg tgtgtcaaag gggtttaaag gggtgtggat tgaatgaatg     2520

gtacgtgcga agtatatgct gattatagaa ccacttgatc tctgcattcc aaattgtaaa     2580

actgactcaa ctggagaaat tataacaaag aggtttgtgg tagacatgta ataagtatag     2640

aaaagcaaaa agaaaagaga aactgcttta gtttctgttt agagaaagct gctgttaata     2700

tttttggata gtagcctttc agctttcaga tattttctac ttacatatgc atatttttga     2760

aacaaaaagt aggctttttt tttgcttttt aaacctaaac attaaatata ttttcccttg     2820

ggtaaaccta cacatcctaa tccctgttta tagaatttta acataattta attgtgtttg     2880

gagatgaggt ggttttcagt ttatttttca tattataatg ctgtgacgag tatccttatc     2940

tgtacacttc tgaacattgt ggagttcttt catgtggatg cctggagata aaattgtgtc     3000

gagatatata tgtattttta aatgtttgat ctgcattgct agattgccat ccagaaaagt     3060

taatcaattt gtattcacag cagcagtgta caagagggct ggttttctga agataacatt     3120

tttttcagtc ctgttcagag gtttggtcaa tcttacctgt agatgacttc agccaccagg     3180

ctggatggga gcccacagac aaaaggacat tggtgtatgt tatggtgaaa accatcagta     3240

ccatgcctag ctcaagaatg tgaaattgaa cctgaaaaaa actttgaacc tacaatttta     3300

tgttctgaaa atagttattc taatgtgagg gcattaataa gaatatgtac catcaaagct     3360

tcagaagatt ttccgtacaa actaaaatca cttttggaga aagtacctaa ataaaaagag     3420

aaacaaatcc aggagatact gtacggtttg aaagaaaggt aatcaaatac tcagaaaaag     3480

tttgttgatg acttaaaaag gataaataaa aagtaagact aaagaaaatc agtataccca     3540

ttaataataa atctttagta atctataagg ggaagaatgc ttttcaacct tatacactag     3600

aagcatgctc tttaaaatta atgcaacagg atgacgactt gatgtagaaa ctatatgtgg     3660

aattatagat taaaatgtga ttgaaacata                                      3690


<210> 289
<211> 1848
<212> DNA
<213> Homo sapiens

<400> 289
aatcacgcct cagccacctc ccgcaagcct ctcactgcct cagccacgct ttccaggctg       60

gtttctggtc cccatccgcg gctggtccgg ccctgggacc gaatcacttc ccagcgagag      120

gaaggtcaaa tttctcgacc ggctacggga aggtcgcggc cgccgccctg tcagccgcct      180

cggcgccccc aggacccctc gggtctcttt aaccggaagc ggaagtgcgt gtcggcggga      240

tcatggcgac tttggtcgaa ctgccggact cggtcctgct cgagatcttc tcttacctcc      300

cggtacggga ccggatccgc atctccaggg tctgtcaccg ctggaagagg ctggtggacg      360

accggtggct gtggcgacat gtcgacctga cgctctacac gatgcgacct aaagtcatgt      420

ggcacctcct tcgaaggtac atggcatccc ggctccattc cctgcggatg ggtggctacc      480

tgttctctgg ctcccaggcc ccccagttgt cccctgctct gttgagagcc ctgggccaga      540

agtgccccaa cctgaagcgc ctctgcctgc acgtggccga cctgagcatg gtgcccatca      600

ccagcctgcc cagcaccttg aggaccctgg agctgcacag ctgcgagatc tccatggcct      660

ggctccacaa gcagcaggac cccaccgtgc tgcccctgct tgaatgcatc gtgctggacc      720

gcgtccccgc cttccgtgac gagcacctgc agggcctgac gcgcttccgg gccttgcgct      780

cgctggtgct gggtggtacc taccgtgtga ccgagacagg gctggatgct ggcctgcagg      840

agctcagcta tctgcagagg cttgaggtgc tgggctgcac cctgtctgcc gacagcaccc      900

tgctggccat cagccgccac ctccgagatg tgcgcaagat ccggctgacc gtgaggggcc      960

tctctgcccc tggcctggct gtgctggagg gaatgccggc cctggagagt ctgtgcctgc     1020

agggtcccct cgtcacccca gaaatgccct cccccactga aatcctctcc tcctgcctca     1080

ctatgcccaa gctcagagtc cttgagctgc aggggctggg gtgggagggt caggaggcgg     1140

agaagatcct gtgtaagggg ctgccccact gtatggtcat cgtcagggct tgccccaaag     1200

agtctatgga ctggtggatg taactactcc acctgccctt gggacccatc ccagttttca     1260

tcattgagcc ccagaccctc tgagcagcac cttgaagagg gcagataatc agacttgagg     1320

aaactgaaag ccccaggttg agagaacaga ggcctaggga cctccagacc attggaatca     1380

ctgtttgcca gctgtgtggc cttggtcata tcatcagcct ctgggaagcc tagttcccac     1440

atctggaaat aaggatgatc atagctacct cacggttaca ttgcaaagcc ttactctaaa     1500

agctcccagc ctccagaggc tctcaatgaa gagtcacctt catggtcgtc ttcaggaaca     1560

ggacggatga agaaggggtg gggttaagac tcaggggcac ctgagggtct gagccccctt     1620

atgagtaccc aagaaggact gtctatgcat gcacacccac aagcctatac accatttata     1680

tacctacacg cacgcaagag acgcggagag ataggcgatg cagactcgcg attcaatgat     1740

cgatatgctc ataaaagtgc tcaattatat tttctgtatt ttgtatgctg tattttccaa     1800

gacgtatatt attttactat taaagaaaaa aatcattttt ttttcccg                  1848


<210> 290
<211> 3969
<212> DNA
<213> Homo sapiens

<400> 290
gggcggctcc gggctcgggt tctgcggcgg cgcctgcagc gcggatcccc cacgtccccg       60

ctcgggccgg gcctcagaaa cgggcgagcc cgggcgcggg aggaagcggc ggccccggct      120

cgggtcctgc gacgcccagc tcccctccgg ggcgcccccc gaggggtccc cgccccccgc      180

cgcggccccg cccctgcctc aaggccccgc cccccgtggc cggcgctggc cccgcccctt      240

ggcccgggct gctgggagtc cccggcgggg cgggggtcag ctctggtccc gttggtcctg      300

ggcgcggcgc catggcctcc gaggcggtga aggttgtcgt gcgctgccgt cccatgaacc      360

agcgggagcg agagctgcgc tgccagcccg tggtgactgt ggactgcgcg cgcgcccagt      420

gctgcatcca gaacccgggc gccgccgacg agccgcccaa gcagttcacc ttcgacggcg      480

cctaccacgt ggaccacgtc accgagcaga tctacaacga gatcgcctat ccgctggtgg      540

agggcgtcac tgagggctac aatggcacca tctttgccta cggccagaca ggcagcggga      600

agtccttcac catgcagggc ctgccggatc cgccctccca gagaggcatc atccccaggg      660

ccttcgagca cgtgttcgag agcgtccagt gtgcagagaa cactaagttc ctggtccggg      720

cctcctacct ggagatctac aatgaagatg tccgggacct ccttggggct gacaccaagc      780

agaagctgga gctgaaggag cacccagaga agggcgtgta cgtgaagggg ctgtccatgc      840

acacggtgca cagcgtggcc cagtgtgagc acatcatgga gactggctgg aagaaccgtt      900

cggtcggcta cacgctgatg aacaaggatt cctcacgctc gcactccatc ttcaccatca      960

gcatcgagat gtctgccgtg gatgagcggg gcaaggacca cctccgggcg ggcaagctga     1020

acctggtgga cctggcgggc agcgagcggc agtccaagac cggggccacg ggcgagcggc     1080

tcaaggaggc caccaagatc aacctgtcgc tctcggcact gggcaatgtc atctcggcgc     1140

tggtggacgg gcgctgtaag cacgtcccct accgtgactc gaagctgacg cggctgctgc     1200

aggactcact gggcggcaac accaagacgc tcatggtggc ctgcctgtcg cctgcggaca     1260

acaactacga tgagacactc agcacgctgc gctacgccaa ccgggccaag aacatcagga     1320

acaagccgcg catcaatgag gaccccaagg atgcgctgct tcgcgagtac caggaggaga     1380

tcaagaagct caaggccatc ctgacacagc agatgagccc cagcagcctg tcagccctgc     1440

tgtccaggca ggtgccccca gaccctgtgc aggtggagga gaagctgttg ccccaacctg     1500

tgatccagca tgacgtggag gccgagaagc agctgatccg ggaggagtat gaagagcgcc     1560

tggcccggct gaaagccgac tataaggccg agcaggagtc tcgggccagg ctggaggaag     1620

acatcactgc catgcgcaac tcatatgacg tcaggctgtc cacgctggag gagaacctgc     1680

ggaaggagac agaggctgtc ctgcaggtgg gagtcctcta caaggctgag gtcatgtcca     1740

gggctgagtt tgccagcagc gctgagtacc cgcctgcttt tcagtatgag acagtggtga     1800

aacccaaggt cttctccacg actgacactc tgcccagtga cgatgtctcc aagactcagg     1860

tttcctccag gtttgcggag ctgcccaagg tggaaccctc caaatctgag atttctctgg     1920

gctccagtga gtcatcctcg ctcgaagaaa cctctgtgtc cgaggctttc cctgggcctg     1980

aggagccctc caacgtggag gtctccatgc ccactgagga gtccaggagc agatacttcc     2040

tggatgagtg cctcgggcag gaggccgctg ggcacctgct gggggaacag aactacctcc     2100

cgcaagagga gccgcaggag gtgcccctgc aggggttact aggcctgcag gacccgtttg     2160

ccgaggtgga agccaagctg gccagactct cctccaccgt ggccaggaca gatgcacccc     2220

aggcagacgt ccccaaggtc cctgtgcagg tccctgcgcc gacagacctg ctggagccca     2280

gtgatgccag gcccgaagcc gaggcggctg atgacttccc gcccaggcct gaggtagatc     2340

tggcctcgga agtggcctta gaggtggtgc ggacagcaga gcctggcgtg tggttggagg     2400

ctcaggcccc ggtggccctg gtggctcagc ctgagcccct gccggccaca gctggtgtga     2460

agagggagag cgtgggcatg gaggtggcag tgctgactga tgacccgctg cccgttgtgg     2520

accagcagca ggtgctggcc cgtctgcagc tgttggagca gcaggttgtg ggtggagagc     2580

aggccaagaa caaggacctg aaggagaagc acaagcggcg caagcgctac gcagacgagc     2640

gcaggaagca gctggtggct gccctgcaga actcggatga ggacagcggg gactgggtgc     2700

tgcttaacgt ctacgactcc atccaggagg aagtgcgggc caagagcaag ctgctggaga     2760

agatgcagag gaagcttcgg gcagcagagg tggagatcaa agatctgcag tccgagtttc     2820

agctggagaa gatcgattac ttggccacca tccgccggca ggagcgtgac tccatgctct     2880

tgcagcagct cctggagcag gtgcagcccc tgattcgcag ggactgtaac tacagcaacc     2940

tggagaagat tctgcgtgag tcctgctggg acgaagataa cggcttctgg aagatcccac     3000

atcccgtcat cacaaaaacc agcctcccag tagcagtttc aactgggcca cagaacaaac     3060

cagcccgcaa aacctctgca gcagacaatg gcgagccgaa catggaggac gaccgctaca     3120

ggctcatgct cagtcggagc aacagtgaaa acattgccag caactacttc cgatctaagc     3180

gggccagcca gatcctcagc acagacgcca ggaagagcct cacacatcac aactcgccac     3240

caggcctcag ctgcccactc agcaacaact ctgccatccc acccacccag gcccctgaaa     3300

tgccccagcc ccggcccttc cgcctcgagt ccctcgacat ccctttcacc aaggccaagc     3360

gtaagaaaag caaaagcaac tttggcagtg agcctctgtg agcacagctg cttgccattg     3420

cctgccttat aggcatgtag agactgccag gccctcccag ggcagcccca accaggtctc     3480

ctcccacctg ccacacagcg ctccggggcc tgagggctcc ctcagccctg ggaagacaca     3540

ttcccttccc tgttccccag agagcccacc tccgccctgg gcaggagccc ctcggaggct     3600

gtatagtcct ccttagagag gcctgctcca gctgttcata ccacatcagt gtttccgtct     3660

gctcacctgc cacagagccc acacccatgc ccaccagtgt tggtctttgc ctcaaagcct     3720

gagacctgct tcacggcctt caccagccct gatggagagg gcagcagctg ccacgtggag     3780

gaagctcaat atcagctggg aaggaactgt gcctctgtct gactggcccc acttcctaag     3840

cactgccctg ccccatgggg tggcacaggg gtcccacagc aggtcttcct gcactgccca     3900

cccctggctg gtctgtggcc caaggaaggc cactccacat taagctgccc aataaactgc     3960

ttttaagat                                                             3969


<210> 291
<211> 1000
<212> DNA
<213> Homo sapiens

<400> 291
aacctcacga ggccttacgt gcctagagcg gttcctctcc gtggcgccct accgccttcg       60

gcgcgaaggt ggctggtgcg taccgtcccg aaccctagga gccgaggtga gcgccgcgaa      120

gacccccgac attaagaagt ggtgtccacc gcagccccct taagccggat accctccccc      180

accccgagga gcaagcctgc cttccgccac gcgccgcccg tcttccgcgc ccgcgcagaa      240

cctcgcggct gtgcccgcct aaagccacgc ccatcctctc ttggccacgc cctcagagac      300

tcctcccctg tcgcccagat cccacccgca ggaccccaaa acccaatgat cctgcagcag      360

cccttgcagc gaggccccca gggaggggcc cagcgcctcc cgcgggccgc cttgggggtg      420

acttggggcc tggacgccag ctcccctctc cgaggagctg tgcccatgag caccaagcgg      480

cgcctggagg aggagcagga gcctctgcgc aagcagtttc tgtctgagga gaacatggcc      540

acccacttct ctcaactcag cctgcacaat gaccacccct actgcagccc ccccatgacc      600

ttctccccag ccctgccccc actcaggagc ccttgctctg agctgcttct ctggcgctat      660

cctggcagcc tcatccctga ggccctccgt ctgctgaggc tgggggacac ccccagtccc      720

ccctaccctg caaccccagc tggggacata atggagctct gagtgctggt ggacagtgcc      780

cctcccacct tccttcttcc ccacaacaga agagaccagc gactcccgca aagggacaag      840

gttcctccct ctcctgcaga gtaggcatct gggcaccaag accttccctc aacagaggac      900

actgagccca acggagttct gggatgggag gggtgggagc atgggaaggg aggcatccca      960

cccccaagaa gaactgaata aagattgctg agcaaaggaa                           1000


<210> 292
<211> 3718
<212> DNA
<213> Homo sapiens

<400> 292
acctgcgctg ggcgggcggg aacggcgcgc ggcgagctga gggtggcggc ggtcgacatg       60

ttccaggtcc cggatagcga gggcggccgc gccggctcca gggccatgaa gcccccagga      120

ggagaatcga gcaatctttt tggaagtcca gaagaagcta ctccttccag caggcctaat      180

aggatggcat ctaatatttt tggaccaaca gaagaacctc agaacatacc caagaggaca      240

aatcccccag ggggtaaagg aagtggtatc tttgacgaat caacccccgt gcagactcga      300

cagcacctga acccacctgg agggaagacc agcgacattt ttgggtctcc ggtcactgcc      360

acttcacgct tggcacaccc aaacaaaccc aaggatcatg ttttcttatg tgaaggagaa      420

gaaccaaaat cggatcttaa agctgcaagg agcatcccgg ctggagcaga gccaggtgag      480

aaaggcagcg ccagaaaagc aggccccgcc aaggagcagg agcccatgcc cacagtcgac      540

agccatgagc cccggctggg gccgcggcct cgctctcaca acaaggtcct gaacccaccg      600

ggaggcaaat ccagcatctc cttctactaa gagaagccac tgctccaccc ggagccagac      660

cagaaactca agagataggg tagccatgtt ttcatttcct tttgcccaaa tgagcggggt      720

gggaagaggg ttagtcttat gtgagcctgg ctgctcagcg tctcctggcc gtcatgacag      780

ctgcttggag acccgtgcct tccagatggc tgggagatgc ctctgtgggg atgaaatggg      840

gcacccctgg ccatcactca tgtgtagtcc aggtttgaga ggaactggaa ggggggtgag      900

ggtggggagg tggggcaggg catggtcctt ggatcaacag cccgccagct gattggatgt      960

ctaggaatga ctgaaagaaa ccaaaacagc ctgtccactg ctgctgtggg atggaggagg     1020

cgtaagcaga aacactaaca gtatattgac ctcttagcag aaccgcttcc attctggaga     1080

tcacggctgc taaatccagc atccccactt cattttaccc ccagcatatt gttctgtagt     1140

cttttcttga aacatcttga ttgcttttcc tcggcagctt tcaaaaaacc aaataataat     1200

agttatccgt cttctacttc atggaagatt gttttggtgc cctgaccctc tgaagtgccc     1260

agttcctgcc atctgaaacc tcggcctgat ctgatctcat gttggaatct gcctgtcttt     1320

cacacagggc tggtcttggt cctttacatg ccagttttgc ttgtgaattc ttgctttttt     1380

cctctcatca gccttaagtt taggcgtttg ttgttctcca gtgatgtaga cagttccctt     1440

cacaagtcac agttcttccc ataaatgagg cccgctgacc tctgcgggac tttaaaaatc     1500

tattcagata tttccgagta agtggcttgt ttaaattctt cctgtgtctt tctttattcc     1560

ttaattggtt ggtggaaaga agagatgctt gggaaccttg ggttcttagg tttggattct     1620

ttaataatat ctaaaaagct aaattttaaa taccagcttt acataaatga ttgttgactc     1680

tggtctgttt ctgacacctt tccagaaaaa agtcaattgt tcaggtacac caaagaggaa     1740

gaagagctgt ggaggccacc ctctacaaag ctttatagaa cttctggatc taactcacaa     1800

acaagcttcc agaagagact agagacctta ggccaggaga tgaaggagtt cagtagcaaa     1860

gtcacacctg tccaattccc tgagctttgc tcactcagct aatgggatgg caaaggtggt     1920

ggtgctttca tcttcaggca gaagcctctg cccatccccc tcaagggctg caggcccagt     1980

tctcatgctg cccttgggtg ggcatctgtt aacagaggag aacgtctggg tggcggcagc     2040

agctttgctc tgagtgccta caaagctaat gcttggtgct agaaacatca tcattattaa     2100

acttcagaaa agcagcagcc atgttcagtc aggctcatgc tgcctcactg cttaagtgcc     2160

tgcaggagcc gcctgccaag ctccccttcc tacacctggc acactggggt ctgcacaagg     2220

ctttgtcaac caaagacagc ttcccccttt tgattgcctg tagactttgg agccaagaaa     2280

cactctgtgt gactctacac acacttcagg tggtttgtgc ttcaaagtca ttgatgcaac     2340

ttgaaaggaa acagtttaat ggtggaaatg aactaccatt tataacttct gtttttttat     2400

tgagaaaatg attcacgaat tccaaatcag attgccagga agaaatagga cgtgacggta     2460

ctgggccctg tgattctccc agcccttgca gtccgctagg tgagaggaaa agctctttac     2520

ttccgcccct ggcagggact tctgggttat gggagaaacc agagatggga atgaggaaaa     2580

tatgaactac agcagaagcc cctgggcagc tgtgatggag cccctgacat tactcttctt     2640

gcatctgtcc tgccttcttt ccctctgcga ggcagtgggg tgggattcag agtgcttagt     2700

ctgctcactg ggagaagaag agttcctgcg catgcaagcc ctgctgtgtg gctgtcgttt     2760

acatttggga ggtgtcctgt atgtctgtac gttggggact gcctgtattt ggaagattta     2820

aaaacctagc atcctgttct caccctctaa gctgcattga gaaatgactc gtctctgtat     2880

ttgtattaag ccttaacact tttcttaagt gcattcggtg ccaacatttt ttagagctgt     2940

accaaaacaa aaagcctgta ctcacatcac aatgtcattt tgataggagc gttttgttat     3000

ttttacaagg cagaatgggg tgtaacagtt gaattaaact tagcaatcac gtgctcagag     3060

cttttgcctg tcagttgtgt gtgtccctta tagtcccttc ccccacagct cttgctgaaa     3120

gagtttgcct tgttttgttt tgttgttttg tatttagcca gaggatgcca aaattagtct     3180

tctcaaagct ttgagtagag taagtgtggg aataagccag tttttttttt tctgtttctg     3240

taacttaaat gaacgggttt ttttcccttg tatgccactt gtcctaacat gtccttaagg     3300

tgtttaacct gcctctgacc tggcttgcaa tgcataggtg aggagaagca gagagcttgt     3360

catatgcaag tcctgtcaag aaaacaggtg ggcatggtgg ctcaggtctg tagtctttgg     3420

gtctttggga ggccagggtg ggaggatcac ttgagctcag gagtttgaga ccagcctaga     3480

caacatacta cgaccctgtc tatacaaaaa aaaacttctc taaattagcc ggatgtggtg     3540

gtgcatgcct gtagtcccag ctactcggga ggctgagtga ggcaggagga tcacttgaga     3600

ccaggaggtt gtggctgtag tgagtgatga tcatgccact gcacttcagc ctggaccaca     3660

gagcaagacc ctgtgtaaaa aaataaaata aaaaacagat tggatgtctt tcttctga       3718


<210> 293
<211> 4282
<212> DNA
<213> Homo sapiens

<400> 293
gtgagtcagc attggcggcg gccccagcgc gtggcagccg tgcgccgcca aggtgcgggt       60

ctcgttactc ggcggtcagg agcgggccct cccttaggtg cgccccccgc caggttctgc      120

gttagacctg catcttagca atgtgaatat tgcatcccta gagaaggacc tggaagagca      180

agacggccac gacctgggag cagcaggtcc caggtcgctg gccggctctg cacctgtcgc      240

catccccggc tccctgccca gagcaccatc gctacactcg ccatcctctg cgtccacctc      300

gccgctcggt tcgctgtccc agcccctccc agggccggtg ggctcctcag ccatgacgcc      360

tccccagcag ccgccacccc tgcgttcaga gccgggcaca ctgggctctg cagcctcatc      420

ctacagcccc ctaggtgagt gccggctccc tccatgctgg cgttgccgtg aagcctccgt      480

ggggctccct cccagatgcc gtcctgactg aggggcctca cacggaacct tgtgccctat      540

ctgtggtggc aaaccacatg acctgctgct cacaggttcc cccacgccgc agaccgagtc      600

tcgctctgtc gcccaggttg gactgcaatg gtttgaacgg tgtccccggg agcatctggg      660

actttgtttc cggcagcttc tcccccagcc cctcccccat cctgagtgcc ggccccccat      720

cctcttcgag tgcaagtcca aacggagctg agctggcccg ggtcaggcgg cagctggacg      780

aggccaagag gaagatccgg cagtgggagg agtcctggca gcaggtgaag caggtctgcg      840

atgcctggca gcgagaggcg caggaggcca aggagcgtgc ccgtgtggcc gatagcgacc      900

ggcagctggc gctgcagaag aaggaggagg tggaggcaca ggtgaagcag ctgcaggagg      960

agctggaggg cctgggcgta gcctccacac tgccggggct gcggggctgt ggggacatcg     1020

gcaccattcc cctgccgaag ctgcactcgc tgcagagtca gctgcgcctg gacctggagg     1080

cggtggacgg cgtgatcttc cagctccgcg ccaagcagtg tgtggcctgc cgggagcggg     1140

cccacggtgc tgtcctgcgg ccctgtcagc accacatcct ctgtgagccg tgtgcggcca     1200

ccgcacctga gtgcccctac tgcaagggcc agcccctgca gtggtgacct cagcggggac     1260

agccacctcc tgctgggcac cctggctcca gcgctcctcc tgaccacgga catgtcgtca     1320

ctcgcttctg gtgccaccga cgtgaggacc gaggctggga gcccttcctg ttacacgtta     1380

tcatgaggct gggagccccg cctgcgcttg gcctgacagc ctttcctgtc acacgttgtc     1440

acctatctag tcctaccgac ggtttcaagg tattttcctc aaaaacctta aatgcaaacc     1500

cacagaaccc gcctgcctgt ccctgagggg cctggtgcct ccgggatcca cgcggcgctg     1560

tgatcacagc agtttgtggt cctgacacta ctgtgactag gccactggga gctggggtct     1620

ttcaaagcac tttgtaaacc gaggaattta gttagaggtt ataaattgct ctaagctgct     1680

ttctgttttt ttttaatatg cgataatatg aagctttata tgtgtactgt gaacttaaat     1740

atttcatatc agtttattgt caattcatag tatgctaaat atattagatt tcatattctg     1800

aaactagtac ttatgaaatg agtgtttatc tagtagtaag acctaggatt tttacatttt     1860

ccaattaagt gcaaatagta tttataagca gagtgattat ggattgagat gtttttaact     1920

tgatggaagg agctagtttt cctgagcctg tgtgtgcacc aggcactggg gctgatgttc     1980

cagcctcgtg gcgtgggagc aggagagctc cgtcctgcat ttctgtggtc cgtggccgct     2040

gtttctgtgc gcctgcgcct cggagagcaa gtgaaggagc atcatgggtt ttgttttctc     2100

ccttaaccct ctgaaagaca gtttgatact aacaaaaaac gcagcagagg ggatccgacg     2160

tcagagcttt tagaattact tttttaagca gctgtcttct ggctgggtgc ggtggctcat     2220

gcctgtgatc ccagcacttt gggaggcggg tggatcacct aaggtcagga gttcaagacc     2280

agcctggcca acatggtgca accccgtctt agtaaaaata caaaaattgg cctggcgtga     2340

gagcgggcac ctgtagtccc agctactcgg gaggctgagg caggagaatc gcttgaacct     2400

gggaggcaga ggttgcagtg agccgagatc gcgccaccgc actccagccc gggtgacaga     2460

gcgagactct ggctcaaaaa aaaaaaaaaa aagctgtttt ctgattactc agagctgtcc     2520

taggcaatgg tgctttgtag ctccttggag atgtcgctgg gcgtcctggc aggggtcagg     2580

cagtgaactg ggagagtggt tgcctcccca gcacccgtga ccaccctggt cctgctcgtg     2640

tgggagatgc tcgggccgtg tgtgcgccag ggtccggggt gccgggtgta tgtggcagtc     2700

acctgacccg cgctgccagt tatcatcgga gctcatccat gtggccagtg aggtcacagg     2760

agaggacccg gccacagcct ctcagtggcc tggagcacac gggggaagcg acccccccca     2820

ggtcccggct ctgctgtggt cccctgtccc gtctgcccct ggagcgacag tgtggtttcg     2880

gccgcagcag aaacgtgact gagaacgcat ccccgcgatg acctgaccct tctgctcagg     2940

gctgggactg tccctaggag ttgagcagga acaggcatct gtggtttacg gcgacctggc     3000

tctccgcggg ccacgtgggt ggtgagggca cacgagtggg aagcggcacc gacgtgtttc     3060

tccccgaccg tggctttgcc aaagactttt aatagcattt tttaagtgca aaacgtctag     3120

gtaaaaatct ttatcatcag tgaccaaatt agaatgtatt taatatagta ggtggtttaa     3180

gaactgtttt aacgtaagac aaactgatag caacattctg ttgttttaaa ggaagtgggt     3240

ccgtgacatt ctgcagctag tccactactc caaggtaact atcgacttgg tttcagtgaa     3300

tctattttgt ttttaactac agtgatttat tagctcagta tctagaaatt acgtatattt     3360

tgtgctactg tcatcgatgt gtaaactctg tttttatttg tatttatgca cttggttccc     3420

atttggagcc tctggtcttt tctgggataa gtggtgtctg ccgagacatc tcccggttgt     3480

cagtggtcag gagcagctga gctctagtct gccagctgct ctgctctttc tgggaaggag     3540

gtggcgcccg cccctcaggg tgtctccagg gctcagcttc cggggtggta gagctgggga     3600

gccccagggg tggggggaca gctgggagat ggaggtggca cctgctcccc tagatcagta     3660

ctggctctga ggacaggtga gcagtgggaa gaccaaagaa tggctggcag cgctgccagg     3720

gttggaaatg ggggcaagat cctggggctg tgtgccctgg ggcctccctc acctgtcttg     3780

gtggccatgg cctcagggat ggctcctagg tggctgaggc acagcagtgg ctggaaggtg     3840

ccccgtggag gctgaggtgg aggcgcgccc agcagctccc ccctgtggcc atggcgggca     3900

cggggcgtag gagctggctg gcggccggct ctgcatgttc ttgttgcctg tcgtctgtaa     3960

ctctagtgtt cgacattcgc cgtgatacag tggtgtcacg acgtgtgtaa ctgtggtcag     4020

cagaccttgt tccgcgtgga cgcctcaagt ggattaattt ctggaagcct caatctgtat     4080

gtttgagtat ttacatgaga atgttatttg aatggaattt tcttaaccca gaaggtagta     4140

tttataatca tttacttgta gcgaactgtt taaagttaac acttgtttaa atttttttac     4200

actatagcat ttatgcaatg gtttacagaa ttcatggagt tatttttatc agtatgggaa     4260

ttaattaaaa ccttgaatct tt                                              4282


<210> 294
<211> 5612
<212> DNA
<213> Homo sapiens

<400> 294
attcagcctc ttcggaccct ctctcactcc ctgtcttccg gagcgtgagt gaagcccggg       60

tgaggtgttt tcccacacgc cgggggcccg gagctgagaa ggggcatggc cagcatcacg      120

cagctgttcg acgacctgtg tgaggccctc ctgccggctg ccaagactca cctgggccag      180

cgcagtgtga accggaagag ggcaaagcgg agcctcaaga aggtggccta caatgctctt      240

ttcacaaatc tttttcaaga tgagactcaa cagctgcagc ctgacatgtc aaaactacca      300

gcgagaaaca agatcctcat gttgtccttt gacttgagag tgggtggcct gggccccaag      360

gccgaccgtt tggaggagct tgtggaggag ctggaagcag ccccttgctg tccgcttttg      420

gaggtggggt ctgttttgga cctcctggtt cagctggcag ggagtggtcc ccctcaagtt      480

ctgccgagaa aacgagacta cttccttaac aacaagcatg tggggagaaa cgttccgtac      540

agcggctatg attgcgacga cctgagtgtg tttgagatgg acgttcagtc tctgatctcc      600

agagaagagt gtttgtgtca cagcatgatc caggaaacac ttcaggttat ggaggctgct      660

ccaggcactg gcctgcccac cgtcgggctc ttctcatttg gtgacccttg tggtgacagg      720

ttcgagagag acacccgggt ctcgctcttc ggggcccttg tgcacagccg cacttatgac      780

atggacgtcc gactgggcct gccccccgtg ccagacaatg cggacctctc tgggctggct      840

attaaggtcc caccgagtgt ggatcagtgg gaagacgaag gattccagtc agcgtccaac      900

ttgactcctg attcccagtc tgagcccagc gtgaccccag acgtggacct gtgggaagcc      960

gcacttacct atgaggccag caagcggagg tgctgggagc gagttggctg cccccctggc     1020

cacagagagg agccttacct gacggaggcg ggaagggacg ctttcgacaa gttctgcagg     1080

ctccaccaag gggagctcca gctgcttgct gggggcgtcc tacaggcccc gcagcccgtg     1140

ctggtgaagg agtgcgagct ggtgaaagac gtgctgaacg tcttgattgg ggtcgtgtct     1200

gccacgtttt cgctctgcca gccggcccag gcctttgtgg tgaagcgggg cgtccacgtg     1260

tcaggagcgt ctcccgagag catcagcagc ctgctctcgg aagtggccga gtatgggacc     1320

tgctacacgc gcctgagtca tttctctctg cagcccgtcc tggactcttt gtacagcaag     1380

ggcctcgtgt tccaggcctt caccagtggc ctgaggaggt acctgcagta ttaccgggcc     1440

tgcgtccttt ccactccgcc caccctgagc ctcctcacca ttggttttct cttcaagaaa     1500

cttggccggc agctcaggta cctggccgag ctctgtggcg ttggcgctgt gctcccgggc     1560

acctgtggag gaggccccag ggccgcgttt cccaccggcg tgaagctgct gtcctacctc     1620

taccaggagg ctctgcacaa ctgcagcaac gagcactacc ctgtactgct gtccctgctg     1680

aagaccagct gcgagcccta cacccggttc atccacgact gggtgtacag cggggtgttc     1740

agagacgctt atggcgagtt catgattcag gtgaaccacg agtacctcag cttccgagat     1800

aagttgtact ggacacatgg ctacgtgctc atctccaaag aggtggagga ctgtgttccc     1860

gtgtttctga agcacattgc ccacgacata tacgtctgcg gaaagaccat taacctgctg     1920

aagctctgct gcccccggca ttacctctgt tggtccgacg tccctgtccc ccggatctcg     1980

gtgattttct cccttgagga gttgaaggag attgagaagg actgtgccgt ctacgttggg     2040

cgcatggaga gggtggcccg ccacagctct gtcagcaagg aggagaagga attacgtatg     2100

gaaattgcaa aacaagaatt aatcgctcat gcccgggaag cagcatccag ggtcctgagt     2160

gcactgagtg accggcagat gtcagaacgg atggccttgg atgcccggaa gcgtgagcag     2220

tttcagaggc tgaaagaaca atttgtgaag gaccaggagc gacgccaggc ggccaggcag     2280

gaggagctgg atgatgactt cagctacgcc cgtgaactcc gagacaggga gagaaggctg     2340

aagtccctgg aggaggagct ggagaggaag gcgaggcagg cactggtcga ccactacagc     2400

aagctctctg cagaggcagc tcgtcgggag cagaaggcac tgtggagaat ccagaggcac     2460

cgactggaga gtgcacggct tcgttttctc ttagaagatg agaaacacat tcaggagatg     2520

ctgaaagcag tgtctgaggc tcaccagccc caggagccgc cagacgtcct cttgagcgtg     2580

cacccccagg tcacgtctcc gggccctgag cacccagagg gaggccaagg ctgtgattct     2640

gggtctgcag agcaacactc gcctgcctgg gatggctgga acaggccagg cctgctgacc     2700

ccacagcccc ttaagcctct agcagtgggg gctggtggca gggggctgca gcaggcggag     2760

ggggccagac ccttctctga cagcctcagc attggagact tcctacctgt gggcccaggg     2820

gctgagccgt ccgtgcagac tggcatggtc cctctcctgg aggtggcgct gcagaccatt     2880

aacttggacc tgcccccctc agctcctggg gaggcacccg cagcagccag cactcagccc     2940

tccaggccac aggagtacga ctttagtact gtcctgaggc cagctgtggc cacctcacct     3000

gcaccagggc ccctgcaggc tgcagagtgc agcttgggca gctcagggct acagctgtgg     3060

gaggacagtt gtgggaagat ggatgcctgt ggctccgcct cgcgggagac tctgctcccc     3120

tcacacccac ccaggcgtgc tgctctggag gaggggagca gccagcccac agagcggctc     3180

tttgggcagg tgtcaggggg tggtcttccc acaggggact acgcttctga aatagctccc     3240

acccggccac ggtggaacac ccacgggcac gtgtctgacg ccagcatcag ggtcggggag     3300

aatgtgtcag atgtggctcc cacccagcca cggtggaaca cccacggaca cgtatccaat     3360

gccagcatca gcttagggga gtctgtgtca gatgtggctc ccactcggcc acggtggaac     3420

atccatggac atgtgtccaa cgccagcatc agggtcgggg agaatgtgtc agatgtggct     3480

cccaccaggc cacggtggaa tacccacggg cacgtgtcca acgccagcat cagggttggg     3540

gagaacgtgt cggacgtggc tcccacccgg ccacggtgga acacccatgg acacgtgtcc     3600

gatgccagca tcagcttggg ggagtctgtg tcagacatgg ctcccgcccg gccacggtgg     3660

aacacccatg gacacgtgtc tgatgccagc atcagcttgg gggagtctgt gtcagacatg     3720

gctcccaccc ggccacggtg gaacacccac ggacatgtgt ctgacaccag catcagggtt     3780

ggggagaacg tatcggacgt ggctcccatc cggtcacggt gcaacaccca tggacacgtg     3840

tccgacgcca gcatcagctt gggggagcct gtgtcggatg tggtttccac ccggccacgg     3900

tggaacaccc atgtacccat ccctccgccc cacatggtgc tgggggctct ctcaccagaa     3960

gctgagccca acacacccag gccccaacag agcccccctg gccacacgtc ccagtcagcg     4020

ctcagcctgg gagcacagag cactgtgctg gactgtgggc cacggctgcc tgtagaagtg     4080

gggccatctc tgtcctcccc cagctcgggc tgcggggagg ggagcatcag cgtgggggag     4140

aacgtgtcag acgtggctcc cacccaacca tggtggccca acaccccggg agacagtgtc     4200

tctgaagaac taggccctgg gaggagcggg gacactgagg acctctctcc aaattggcct     4260

ctcaactcac aggaagacac agctgcccag agcagcccag gccgtggtga ggaggcggag     4320

gcatcggcgg cggaggctca gggtggggag caggcctacc tggcaggcct ggcagggcag     4380

taccacttgg agcggtaccc ggacagttac gagtccatgt ccgagccgcc cattgctcat     4440

cttttgcgcc ccgtgcttcc ccgggccttc gccttccccg tggaccccca ggtccagtct     4500

gccgctgatg agactgctgt gcagctgagc gagttgctga cgctgcccgt gctcatgaag     4560

cgctccatca cggcaccgct ggccgcccac atctccttgg tgaacaaggc cgctgtcgac     4620

tacttcttcg tggagctgca cctggaggcg cactatgagg cactgcggca cttcctgctg     4680

atggaggacg gcgagttcgc ccagtccctc agcgacctgc tctttgagaa gcttggagct     4740

gggcaaacgc ccggagagct gctcaacccg ctggtgctga actctgtgct gagcaaggcc     4800

ctgcagtgca gcctgcatgg ggacaccccg cacgcctcca acctctccct cgctctcaag     4860

tacctgcccg aggtgtttgc ccccaacgcc ccggatgtgc tgagctgcct ggagctcagg     4920

tacaaggtgg actggcctct caacattgtc atcaccgagg gctgcgtgag caagtacagc     4980

ggcgtcttct ccttcctgct gcagctgaag ctcatgatgt gggcgctcaa ggacgtctgc     5040

ttccacctca agcgcacagc cctgctgagc cacatggccg gctctgtgca gttccgtcag     5100

ctgcagctgt tcaagcacga gatgcagcat ttcgtgaagg tcatccaggg ctacatcgcc     5160

aaccagatcc tgcacgtcac ctggtgcgag ttcagggcca ggttggccac cgtgggcgac     5220

ctggaggaga tccagcgtgc gcacgcagag tacctgcaca aggccgtctt caggggcctg     5280

ctcacggaga aggcggcgcc cgtcatgaac gtcatccaca gcatcttcag cctcgtgctc     5340

aagttccgca gccagctcat ctcccaggcc tgggggcccc ctgggggccc gcggggtgca     5400

gagcacccca actttgcact catgcagcag tcctacaaca ccttcaagta ctactcccac     5460

tttctcttca aagtggtgac caagctggtg aaccgcggct accagcccca cctggaggac     5520

tttctgctgc gcatcaactt caacaactac taccaggacg cctgaggctg ctctgcgggg     5580

gacgtgcaca ataaaggtgt tctcggaccc tg                                   5612


<210> 295
<211> 2788
<212> DNA
<213> Homo sapiens

<400> 295
ccgctgagcg ctgactgggt gcgagtgggg aagctgctaa cccgacccgg attggcgctg       60

aggtggcccg tggggcaggg cagatgattc tggaccagat gaagcctgag gagccttcca      120

gctctaagat agcaggatag gagacttcta agattggagc tgcagaagac ttgccagccc      180

accagcacaa tgtcaggaag ccatacacct gcctgtggcc ctttctcagc cctgactccg      240

agcatatggc cccaggagat cttggccaag tacacgcaga aggaagagtc agcagagcaa      300

ccagagttct actacgatga gtttggtttc cgtgtgtaca aggaagaagg tgatgagcct      360

ggctccagtc tgctggcgaa ctcccctctg atggaggatg ctccacagag gctgcggtgg      420

caggcccacc tggagttcac ccataaccac gatgtggggg atctcacctg ggacaagatt      480

gccgtctccc taccccgctc tgagaagctc cgctccctgg tgctggccgg catcccacat      540

ggcatgaggc cacagctgtg gatgcggctc tctggggccc tgcagaagaa gaggaactct      600

gagctgtcct accgcgagat tgtgaagaac agctccaacg atgagaccat cgctgccaag      660

cagatcgaga aggacctgct ccgcaccatg cccagcaacg cctgcttcgc cagcatgggt      720

agcatcgggg tgccccgcct gcgcagggtg ctccgggccc tggcctggct ctacccagag      780

atcggctact gccagggcac cggcatggtg gccgcctgcc tcctgctgtt cctggaggag      840

gaggacgcct tctggatgat gtctgccatc atcgaggacc tgctccccgc ctcctacttc      900

agcaccaccc tgctgggtgt ccagactgac cagcgggtcc tgcgccacct cattgtccag      960

tacctgcctc gcctggacaa gctgctccag gagcatgaca ttgagctgtc cctgatcaca     1020

ctgcactggt tcctcacggc cttcgccagc gtggtggaca tcaagctgct cctgcgcatc     1080

tgggacctgt ttttctacga gggctcccgg gtgctgttcc agctcacgct gggcatgctg     1140

cacctcaagg aggaagagct gatccagtca gagaactcgg cctccatctt caacacgcta     1200

tcggatatcc cgtcgcagat ggaggacgcg gagctgcttc tgggggtggc catgcggctg     1260

gccggctccc tcaccgatgt ggccgtggag actcagcgcc gcaagcacct ggcctatctc     1320

attgcagacc agggccagct cctgggggcc ggcaccctca ccaacctctc tcaggttgtt     1380

cgccgcagga cccagcggag gaagtccacc atcactgctc tgctcttcgg ggaggatgac     1440

ctggaggcac tcaaggccaa gaacatcaag cagacggaac tggtggctga cctccgggaa     1500

gccatcctgc gcgtggcacg ccacttccag tgcacagacc ccaaaaactg cagcgtggag     1560

ctgactccag actatagcat ggagagccac cagcgggacc acgagaacta cgtggcgtgc     1620

tcacgcagcc accggcgccg agccaaggcc ctgctggact ttgagcggca cgacgacgac     1680

gagctgggct tccgcaagaa cgacatcatc acaatcgtgt ctcagaagga cgagcactgc     1740

tgggtggggg agctcaacgg cctgcgaggc tggtttccag ccaagttcgt ggaagtcctg     1800

gatgagcgca gcaaagagta ctccatcgcg ggggatgact cggtgacgga gggggtcaca     1860

gacctcgtgc gagggaccct ctgcccggcc cttaaggccc tgttcgaaca tggactgaag     1920

aagccatccc tgcttggggg cgcctgccac ccctggctgt ttatcgagga ggctgcaggc     1980

cgggaggtcg agagagactt tgcctccgtg tattcccgtc tggtgctctg taagaccttc     2040

aggttggatg aagatggcaa agtcctgacc ccggaggagc tgctctaccg ggctgtgcag     2100

tctgtgaacg tgacccacga tgcagtgcat gcacaaatgg atgtgaagct ccgctcactg     2160

atctgcgtgg ggctcaatga gcaggtgctg cacctgtggc tggaggtgct ctgctccagc     2220

ctgcccaccg tggagaagtg gtaccagccc tggtccttcc tgcgcagccc gggctgggtc     2280

cagatcaagt gtgagctccg agtcctctgc tgctttgcct tcagcctctc ccaggactgg     2340

gagctccctg cgaagagaga ggcgcagcag cccctgaagg agggcgtccg ggacatgctg     2400

gtgaagcacc acctcttcag ctgggatgtg gacgggtgac cccctcctcc ccagcccaac     2460

ctcgggcctg cgtctgaggt ggcccaggac cccaagctgc agagcccagg gaagagcagc     2520

tccagagccc tggccggggc cgcgggatat caatatcagg ctgccccact ccacgttccc     2580

cagcacatcc caggtggtgg gagcagaggg taccctgccc caccagggtc cttagggatg     2640

ctctaggcca aaccacagtt tgtaccaaaa accttgtgag gaggtggggg agccatgtct     2700

gtgctcagga agagggaagg ggatgggggt ggctagtagg ctcctggcct ctttggttta     2760

taaataaact gtgtctgtct ttgagaaa                                        2788


<210> 296
<211> 2751
<212> DNA
<213> Homo sapiens

<400> 296
ggactgcccc gccctggtcc agtgattgat cagcagtgat tactgaggct ttaatggtcc       60

gcttggatgg gaattaattc tgggatggat aaataatgca tcgaggttta tgtagtccaa      120

ggcgagccgt ccgtccggag ccaggagagg tagccgaggg agcctgacgg gtgacgccag      180

cggccacggg gccccgaacg agcaggacat gaggggcgac taggcgcgag gacgagcaaa      240

agcaagtgga tgacagcatg aacggccctg cggggctggc cggacggctg caagaacatg      300

ctgagcccaa agatcaggca ggccaggagg gcccgctcca aaagcctagt gatgggggag      360

cagagccgga gccctgggcg gatgccgtgc cctcacaggc tgggccccgt gctgaaggcg      420

ggctggctga agaagcagag gagcatcatg aagaactggc agcagcgctg gtttgtgctg      480

cgtggggatc agcttttcta ctacaaggac aaagatgaga tcaagcccca gggatttatt      540

tctctacaag ggacacaggt gactgaactt cctcctggcc ccgaggaccc agggaagcac      600

ctctttgaga tcagcccagg tggtgccggg gagcgggaga aggtgccggc caaccccgag      660

gcgctcctgc tcatggccag ctcccagcgt gacatggagg actgggtgca ggccatccgc      720

cgagtcatct gggccccgct gggcggaggg atctttgggc agcgcctaga ggaaacagtc      780

caccacgagc ggaagtatgg cccccgcctg gcgcccctgc tggtggagca gtgtgtggac      840

ttcatccggg agcgcgggct cactgaggag gggctgttcc gcatgccagg ccaggccaac      900

ctggtgaggg acctgcagga ttccttcgac tgtggggaga agccactgtt tgacagcaca      960

acagacgtgc acacggtggc ctccctgctg aagctgtacc tgcgggagct ccccgagccc     1020

gtggtcccct tcgccaggta cgaggacttc ctcagctgcg cccagctgct caccaaggac     1080

gagggggagg gcactctgga gttggctaaa caagtgagca accttcctca ggcaaattac     1140

aacctgctca gatacatctg caagtttctg gatgaagttc aggcatactc aaatgtcaac     1200

aagatgagtg tccagaatct ggcaaccgtt tttggaccta acattctgcg gccacaggta     1260

gaggacccag taaccatcat ggaaggcact tccctcgtcc agcacctgat gaccgtcctc     1320

atccgcaaac acagccagct cttcacggca ccggtcccgg aagggcccac ctccccgcgc     1380

gggggcctgc aatgcgcagt ggggtggggc tccgaggagg tcaccaggga cagccaagga     1440

gagcccggcg gccccggcct gcccgcgcac aggacctctt ccctggacgg ggcggccgtg     1500

gcggtgctct ccagaacagc ccccacgggg ccggggagcc ggtgcagccc tgggaagaag     1560

gtgcagaccc tgcccagttg gaagtcctcc ttccggcagc cgaggtccct atcgggaagc     1620

ccgaaggggg gcggctcatc cctggaggtg cccatcatct cctccggcgg gaactggctt     1680

atgaacgggc tgtcctccct gcgcggacac cgccgggcct cgtcgggaga ccggctcaag     1740

gactcgggct ccgtgcagag actctccacc tacgacaatg tgcccgcgcc gggcctggtc     1800

cccggcatac ccagcgtggc cagtatggcg tggtccgggg cctcgtccag cgagtcgtcg     1860

gtggggggct cactcagcag ctgcacggcc tgccgcgcca gcgactcgtc tgcccgcagt     1920

tccctgcaca ccgactgggc cctggagccc tccccgctcc ccagcagcag cgaggacccc     1980

aagtccctgg acctggacca cagcatggac gaggcgggcg cgggtgccag caacagcgag     2040

cccagcgagc cggacagccc cacccgggaa cacgcgcgcc gctccgaggc cttacagggg     2100

ctggtcactg agctcagggc cgagctgtgc cgccagcgga ctgagtacga gaggagtgtg     2160

aaaagaatcg aagaagggag tgctgacctg agaaaacgaa tgtcccggtt agaagaagaa     2220

ctggaccagg aaaagaaaaa atacatcatg ctggaaataa agctgcggaa ctctgaacgg     2280

gcgcgggagg atgcggagag gaggaaccag ctgttgcaga gggaaatgga ggagtttttt     2340

tcgaccctag gaagcttgac tgttggggca aaaggtgcca gggccccaaa gtaaaaggaa     2400

tggcagagct cacttctgta ccacgtctgc tggtctccag ccttgtatgg agttagaagc     2460

gtctgtatct ctggagcagc caggcgctct ggagccagct ggagagagag agatcctgat     2520

acctctgtgg ggactgtggg gacttttggg accccacaca ctccaggtgg gatcagatgc     2580

tgctccaacc atgcagttcc tggtgagggt cagaagggga cggtaccaag agtagcgctt     2640

agcccttacc caggaaatat ccttcatggc cacagaaatg gagggcgccc aggatccagg     2700

cagccaccgg gaacagtcag ctttctttat taaatgtgct cacaaagcat g              2751


<210> 297
<211> 1537
<212> DNA
<213> Homo sapiens

<400> 297
agcgagctgt gaacaactcg tgtccaaata agtggctgag aggtggtcct aagtaagcac       60

aagtttagta gtagagtact cgtaacacag aactggctga aaccccgccc tcttgtctac      120

gggcgttctt tcagggcgac tttgtcagta ccccaaactg tccccgcatg aggtcactct      180

gcacggtcac gtgctcgagc ccgcgggagc gccacatcgc cagccgcacc cctccacccc      240

caacctgccc acgtgacccg gcctagtttc tccaggcccg tccctacgtc tcactcggga      300

agccccgccc cacgctgagc gctccgcctg cgaccctccg ccacttaccc accccggctc      360

aagcacgacc cgtggatcca cgtgcttttt cttgtccaat gggagccggc tcccgggcgc      420

gaaggggcgg ggaggaaagg aacgactgtg ctacgttgcc agaaggggcg ggacctgcaa      480

cgtccgacag aacgagggga cgtaacggag gcaggttgga gccgctgccg tcgccatgac      540

ccgcggtaac cagcgtgagc tcgcccgcca gaagaatatg aaaaagcaga gcgactcggt      600

taagggaaag cgccgagatg acgggctttc tgctgccgcc cgcaagcaga gggactcgga      660

gatcatgcag cagaagcaga aaaaggcaaa cgagaagaag gaggaaccca agtagctttg      720

tggcttcgtg tccaaccctc ttgcccttcg cctgtgtgcc tggagccagt cccaccacgc      780

tcgcgtttcc tcctgtagtg ctcacaggtc ccagcaccga tggcattccc tttgccctga      840

gtctgcagcg ggtccctttt gtgcttcctt cccctcaggt agcctctctc cccctgggcc      900

actcccgggg gtgagggggt taccccttcc cagtgttttt tattcctgtg gggctcaccc      960

caaagtatta aaagtagctt tgtaattcct tgagcgcctg gtttgactgg ggacttgggg     1020

ggatggggtt ggaagaatga ctgccctttc ccaccaaaaa agggagaact ctttagattc     1080

agattgtggg tatgtagact taataagtga aacatcacag aagaagcctt tattatacaa     1140

tgacaaccaa acaagtactc cggatatgca gtagaggaat cctctaagaa ccatagagac     1200

ttcttttctg tgatttttgt tccccaccct tgaacaccat ctctaggatg gagttggcct     1260

aagagtgaat gctgcaagat ctgtgtttat gcctcttttc ctcattcttc ctcagtttgt     1320

tcgtctgctt gaaagttggc caaaaaatcc tgctgctcac cgacttcccg tggtcagctg     1380

ctgtcaagcg ttcactttct cttctgtcat tcctcatgga atgagggtgg ttttgtcttc     1440

ccgcttccct tgacctcaaa atcaggatta aaacctgggg tagcctctgt gctcctttct     1500

tctatgccct ggtttgttct gtggttctgg gcttctt                              1537


<210> 298
<211> 2278
<212> DNA
<213> Homo sapiens

<400> 298
aggccctgaa ctatttaagg atccaggtgt tgcaaggcgg taagttttgc agccagtgtc       60

catgaggtcg gggctgggac tagattaggg tagatctaag cctgggcttg ggagtgcagc      120

tagcgcagaa agatctgagg aactagagca aaaagccatg cggatggatt gtggtcgtca      180

gaggctcccg tagtctttag cggcgctggc ttccgcaggc tccgccctct cttgcccacc      240

cggaaacagc ctcgccccgc ctacgcggga cccaaccgcg gcgaccggac gtgcactcct      300

ccagtagcgg ctgcacgtcg tgccaatggc ccgctatgag gaggtgagcg tgtccggctt      360

cgaggagttc caccgggccg tggaacagca caatggcaag accattttcg cctactttac      420

gggttctaag gacgccgggg ggaaaagctg gtgccccgac tgcgtgcagg ctgaaccagt      480

cgtacgagag gggctgaagc acattagtga aggatgtgtg ttcatctact gccaagtagg      540

agaaaagcct tattggaaag atccaaataa tgacttcaga aaaaacttga aagtaacagc      600

agtgcctaca ctacttaagt atggaacacc tcaaaaactg gtagaatctg agtgtcttca      660

ggccaacctg gtggaaatgt tgttctctga agattaagat tttaggatgg caatcatgtc      720

ttgatgtcct gatttgttct agtatcaata aactgtatac ttgctttgaa ttcatgttag      780

caataaatga tgttaaaaaa actggcatgt gtctaaacaa tagagtgcta ttaaaatgcc      840

catgaacctt tagtttgcct gtaatacatg gatattttta agatataaag aagtcttcag      900

aaatagcagt aaaggctcaa aggaacgtat tcttgaaggt gacggaaata cctaaaaact      960

cctaaaggtg cagagcacac cttccaaatc tctcaaaaga tcagtatctt ttattttaag     1020

ttatctccat ctgcaaagca actgatgata ttcctgaaac cccttctttg attttggaat     1080

gtagaaccta acctcaccac tgaaggaaag cacatgacct ctaatctagc ctctgcttaa     1140

ttcaggcagt tttgttttgt ttaataaaaa acagactcct gagcactaga agcagtttgt     1200

tttgcagctg tctcaatgtg ctttacttgg gatgaggcag gtggcggaga gcggccggaa     1260

agactctata acccagttct gggaagaact ccaagctggg agtcagtcac actgactcta     1320

ccacttacta gctgtgtaac cacaggcaag ttactcaccc cgtccaaacc tcagttttct     1380

cttctataaa caaggttctt agaataaaat gagaattcaa ggaagcactt aacatagcac     1440

ctggtttgtg gtacctccca aatcaatggt agctttccca aatgaacaca agtatttgag     1500

gctcctcatg tttgttctaa agtcaagagt ccagttagta actaaccact agttgtcctg     1560

ccatgactag gtcaagtgag gccacagtga ttcagtgatt cttaaagcca ccttgcaaag     1620

caggtaatac agttatttcc tgtcctgcag aattcaagaa cctttatgca gttcctgtcc     1680

tatgatttaa agaggtcagt gactccgcta ctctcactac atcttagagt agagtggtag     1740

agtagttgat ctgagacagt aaggttccag gagatggtct tgccctacta tatgtcagga     1800

acagctagcc ttagaattca gtatacttgg tggcccaccc ctaccccatg ccccagtgcc     1860

ttatttggtc taaagcacct aacttttcca ttcttaatca gctgattatg ctaaatgcgt     1920

aaaaaagaaa aacaccttac aaatccacag ggaaatcaaa gaacaattca ggtttaacag     1980

aaatagtcta ttaacaataa aaagttggat gaaaaagcac actaaaggtt ctaggggcta     2040

ccataataaa ggtagatagg aagagttttc attttttttg tcttcactgt acaaaagaaa     2100

tacattatat acatgtatta agtgcctcgt ttgtatccag tttttcattt tcccgatgtg     2160

ttattttgct gttgctgctc tgccaaggct tgctgaaggc gcatccgctt ccgggaatag     2220

tgctgccaat gtagaatctg ctgttcatca ataaatttcg cacactgagc attcacca       2278


<210> 299
<211> 1580
<212> DNA
<213> Homo sapiens

<400> 299
gcaggggtga agggtgaaaa gcgtcattcg aggtccgggt ccggcttgcg gggtcagcga       60

actggagagg cgccatgggc tggatcacag aagatcttat tagacggaat gctgaacaca      120

acgactgtgt cattttttcc ctggaggaac tctcgttgca tcagcaagaa atagaaagac      180

tagaacacat tgataaatgg tgccgggatt taaaaattct ctatcttcaa aataatctta      240

ttgggaaaat tgaaaatgtt agcaaactca agaaacttga atatttgaat ttagctttaa      300

acaacattga aaaaatagaa aacttggaag gatgtgaaga gctggcaaaa cttgacctga      360

ctgtgaattt cattggagag ctgagcagca ttaaaaactt gcagcacaat atccatctga      420

aggagctctt tctcatgggg aacccatgtg cttcctttga ccactatagg gagttcgtgg      480

tagcaactct tccacaatta aagtggttgg atggtaaaga aatagagcct tcagaaagga      540

ttaaggcatt gcaggactat tcagtaattg aaccacaaat cagagagcag gaaaaagatc      600

actgtcttaa acgagccaaa ctcaaggaag aggctcagag gaaacaccaa gaagaggata      660

aaaatgaaga caagagaagt aacgcaggct ttgatggacg ttggtacaca gacatcaatg      720

ctactctttc ctctttagag agcaaagacc acctacaggc accagacaca gaggaacaca      780

acacaaagaa attagacaac agtgaagatg acttggaatt ctggaataag ccctgtttgt      840

ttactcctga atcaagattg gaaactctta gacacatgga aaaacaacgg aagaaacagg      900

aaaaattaag tgaaaaaaag aagaaagtga aaccacccag gactttgatc actgaagatg      960

ggaaagccct aaatgtgaat gagcccaaaa ttgacttctc tttgaaagat aacgaaaagc     1020

agatcatcct ggaccttgct gtctataggt atatggatac ctctttaatc gatgttgatg     1080

tgcaaccaac ttacgtgcga gtaatgatca aaggaaagcc atttcagctt gtccttcctg     1140

cagaagtgaa acccgatagt agttctgcta aaagatctca gacaacgggt catttggtca     1200

tctgcatgcc caaggtagga gaagtaatca caggtggtca gcgagcattc aaatctatga     1260

aaactacctc ggacaggagc agagaacaaa caaatacaag aagcaagcac atggagaaac     1320

tagaagtaga ccctagcaag cactcattcc ctgatgtgac taacatagtt caagagaaaa     1380

aacacacacc cagaagacga cctgaaccca aaattatacc aagtgaggaa gacccaacct     1440

ttgaagacaa ccctgaagtg cctccgctga tttgaaacat ctggctgcgt tgccattggc     1500

tgagacccac caggtccagt tttggttggt gtagagacca tatgcatatt attcctggga     1560

taaacacaga gttatttgtc                                                 1580


<210> 300
<211> 4615
<212> DNA
<213> Homo sapiens

<400> 300
cctccctctt gttcgtcctc cctccccctg tggactgcgg cgctggcgtt ccgcgcacgc       60

cggctcactg cgcctgcccg gcgtgtggac gccacacgct cccggaagtg ggaggtggcc      120

gctggagttt gtgtggccgc cgccgcggga acgcgagccc ggtaattttt caacggagaa      180

aggcgaggct ttcgggctct gcagagtgag agttagcaag tgtccggctc cagcaactct      240

cctctggcgt gacagccggc atggaggatc cacagagtaa agagcctgcc ggcgaggccg      300

tggctctcgc gctgctggag tcgccgcggc cggagggcgg ggaggagccg ccgcgtccca      360

gtcccgagga aactcaacag tgtaaatttg atggccagga gacaaaagga tccaagttca      420

ttacctccag tgcgagtgac ttcagtgacc cggtttacaa agagattgcc attacgaatg      480

gctgtattaa tagaatgagt aaggaagaac tcagagctaa gctttcagaa ttcaagcttg      540

aaactagagg agtaaaggat gttctaaaga agagactgaa aaactattat aagaagcaga      600

agctgatgct gaaagagagc aattttgctg acagttatta tgactacatt tgtattattg      660

actttgaagc cacttgtgaa gaaggaaacc cacctgagtt tgtacatgaa ataattgaat      720

ttccggttgt tttactgaat acgcatactt tagaaataga agacacgttt cagcagtatg      780

taagaccaga gattaacaca cagctgtctg atttctgcat cagtctaact ggaattactc      840

aggatcaggt agacagagct gataccttcc ctcaggtact aaaaaaagta attgactgga      900

tgaaattgaa ggaattagga acaaagtata aatactcact tttaacagat ggttcttggg      960

atatgagtaa gttcttgaac attcagtgtc aactcagcag gctcaaatac cctccttttg     1020

cgaaaaagtg gatcaatatt cggaagtcat atggaaattt ttacaaggtt cctagaagcc     1080

aaaccaaact gacaataatg cttgaaaaat taggaatgga ttatgatggg cggcctcact     1140

gtggtcttga tgactctaag aatatcgccc gaatagcagt tcgaatgctt caggatgggt     1200

gtgaactccg aatcaacgag aaaatgcatg caggacagct aatgagtgtg tcctcttcct     1260

taccaataga gggcactcca ccaccacaaa tgccacattt tagaaagtaa caacagtttt     1320

gtgtgtggat cattccaatt gaagttgcta tgaagaggta gcagatgaat ctcattgaat     1380

tagtcctgta gtgcaaactt taagcacctt aaaacattta aaatcttatt acaggtgata     1440

gagatagata catgtatgtg aacagatttt gtaggaaggc atactgaatt ctttgtcacc     1500

agcacttttg atatgaacag tattcgttac atagtaacag ttcctgctta caactgaatt     1560

ttataattta aggtgttcaa gatatattct ttttggtttt aaaatgcaaa atcttattgg     1620

ctgttctgtt gaatgtcata tcttactggt gtttaaatat gtaatgtgtt tctttattaa     1680

catcactaga tgaaaccata tcttaaaatg cagaaatgat tggaaggtag atcttatcta     1740

gcctttggat ttcaagaata tcatagtcct tttgattttc aaagtttata tgtgaagttc     1800

accatgtatg tggtgaattt cgtaaggtac ttggtataca tatctgccta tgtttctttt     1860

caactcataa ttggaagaat tatgatggat tatagggttt ggttaaaaat ccagttactg     1920

aaggaattaa tgaaaacgta gaagaaagta ctaaaaggaa tatcataagg gctgtagctc     1980

aaacttcata atacataaat cactggggtc tttttggatt tggttgtttg attcgccttc     2040

cttttttgac atatgtatgc cttaattctt aaatctgagg gaccatgctt tgaaatagac     2100

tgaaaattaa gggtcaccac ctaattttac tttgtattca gtatcgtaag tgaggttaat     2160

aaagtcaata ctttctacca tatattacgt ttttgttatt aaaaaacttc attggccact     2220

agtgaagtta gtcaataaaa gacttgtttt tctgatttta catagtaaat ggctgctaag     2280

tattgagtaa ttcttaacta attctaaaaa ctaaaatgtg catttcgact tgataaggta     2340

aaactcttat ctagaggcta aacccatgta ttttcagaat tgaatttttc tccttgtagc     2400

tttcagggaa caatttcatt gacattgctt gcttcctgcc ttttaccttt taataaaaat     2460

tgtgatgcta ctttattcta aagatttata ttttataacc agatgaattt cctcaaaggt     2520

ttccaaacct atatcatata gggtgaaaag caggaaagta gacatttttc ttggcgtggg     2580

aattctctac atagggcagt agatttctta agccaatgaa tttctgcttt tcagcagtag     2640

tcatataatc agtatcataa agaataatgt gtaaataaca gaaggcatat gagagtgtgg     2700

tgttcctaga tgaactgtta cagattatag taaaataagg aaatctaagt gctttaagtt     2760

tatacagtta actcttagga taagagggat gtatgctgag atgtttgtgc atcccagata     2820

gcactgtaca ataacctgta aagtattact gaatactgaa tagctgaaac tgcaattgga     2880

aaatctgatg atgacgagga aatattacgt ttccagtttt tttagctcta tctgctaatt     2940

tctttgcctg ttttcacttt cgccaagtac caacaagctc atgttgtatt tctttttaag     3000

aacttcaaca ttataagctc tcagtaccct attttgttgt tgttgttgtt tgagacagag     3060

tttttgctcg tctgccagga tggagtgcag tggtgcgatc ttggctcact gcaacctccg     3120

cctcctgggc tcaggtgatc ctcttgcctc agcctcctga gtagctcaga ttacaggcgc     3180

gtgccaccac acccgcctaa tttttgtatt tttggtagag gcggggtttc accatgttgg     3240

tcaggctggt cttgaactcc tgacctcaag tgatttgccc accttgacct cctacagacg     3300

tgagccactg cgctcagcca tagattttac tgtcttaacc cattttaatt cctctgttga     3360

gtctctgtcc tcccctccaa tttgatttgg gattttgctg atgagatgat actaaacatt     3420

gagagtactg ctttttactc tgacttttat tgtgttgtct ttgaaagaca aatagtacaa     3480

ctttttacaa ggaaacacgt aagagatgga tgtccatgaa aacaatatta gtatattcta     3540

ttattgtttc ttattaatag ttacttagta tttacaaaca atttattatt agctgtgtta     3600

acttttattc tatgcttcat atgctctgac attgacatag tggatttctg ctgatttttt     3660

tcaaatccgc aatctttata accaactgaa gtatataata gagcattaca ttttatcttt     3720

atttgtgttc tgttggatca agtatttaac atttgctctg aaaaaaatgt ttttgtgatg     3780

tgtctttgtt gccttgagat agatccattt atcctgcctc ctagggagaa gtttctgcct     3840

ggattgaaac aaaaaaacac aggcgtcaca agcatgttac ctattaagag agagagggta     3900

tctctgaaga ctaattaaaa tggtaatttt taaaaagatg tgaccagttg acttttagta     3960

tatcatccca agtattatcc ccaaaatgat aatgcaaaac agaataattt ggagaccagg     4020

agaaaaactg gtatgattac tggggagggg aagaagcaca ggtggtcaag ataataatgc     4080

atgtttggcc tcagctgtag ttgccaaaga aactacctgc ctcacagatg agcacgcacg     4140

ggtgcattgt caaagtctga gaaggatgta ttgtactttg aaggaagact ttccatttct     4200

aagctaccat ggagaagtat atgctcctcg agaccagaga ctgtgacttc tgcatctttg     4260

attccagcga catatgataa aatgttttgc acatagttga atccagcgtt gatacatgaa     4320

ggacagcatt acatcttttt tctattatac ttagaaattt cctctttgtt ctgcaccacc     4380

aacctgtata tcaagcctcc ttgccccaca aagcttccaa agcccgtaaa tttgttaatc     4440

tagagcaggg gtcagcaaac taccacccat gggccaaatc tggctgctgc ctatttttgt     4500

atggcctaca aactatggtt tttatattcc cttttgttaa tggctcaaaa taatattttg     4560

tataatacga aaattacgaa attttagttt ctctaaataa agttttggaa agaac          4615


<210> 301
<211> 1705
<212> DNA
<213> Homo sapiens

<400> 301
aataaaagca ggctgcctga gccggcagca gcaacctgct ctggttccct tccacgctgt       60

ggaagctttg ttcttttggt cttcatgata aatcttgctg ctgctcactc gttgggtccg      120

tgccaccttt aagagctgta acactcaccg cgaaggtctg caacttcact cctggggcca      180

gcaagaccac gaatgcaccg agaggaatga acaactctgg acacaccatc tttaagaacc      240

gtaatactca ccgcaagggt ctgcaacttc attcttgaag tcagtgaggc caagaaccca      300

tcaattccgt acacattttg gtgactttga agagactgtc acctatcacc aagtggtgag      360

actattgcca agcagtgaga ctattgccaa gtggtgagac catcaccaag cggtgagact      420

atcacctatc gccaagtggc ctgattcagc aggaagcatc tcagacacca accactatgc      480

tgtcagcagt tgcccggggc taccagggct ggtttcatcc ctgtgctagg ctttctgtga      540

ggatgagcag caccgggata gacaggaagg gcgtcctggc taaccgggta gccgtggtca      600

cggggtccac cagtgggatc ggctttgcca tcgcccgacg tctggcccgg gacggggccc      660

acgtggtcat cagcagccgg aagcagcaga acgtggaccg ggccatggcc aagctgcagg      720

gggaggggct gagtgtggcg ggcattgtgt gccacgtggg gaaggctgag gaccgggagc      780

agctggtggc caaggccctg gagcactgtg ggggcgtcga cttcctggtg tgcagcgcag      840

gggtcaaccc tctggtaggg agcactctgg ggaccagtga gcagatctgg gacaagatcc      900

taagtgtgaa cgtgaagtcc ccagccctgc tgctgagcca gttgctgccc tacatggaga      960

acaggagggg tgctgtcatc ctggtctctt ccattgcagc ttataatcca gtagtggcgc     1020

tgggtgtcta caatgtcagc aagacagcgc tgctgggtct cactagaaca ctggcattgg     1080

agctggcccc caaggacatc cgggtaaact gcgtggttcc aggaattatc aaaactgact     1140

tcagcaaagt gtttcatggg aatgagtctc tctggaagaa cttcaaggaa catcatcagc     1200

tgcagaggat tggggagtca gaggactgtg caggaatcgt gtccttcctg tgctctccag     1260

atgccagcta cgtcaacggg gagaacattg cggtggcagg ctactccact cggctctgag     1320

aggagtgggg gcggctgcgt agctgtggtc ccaggcccag gagcctgagg gggtgtctag     1380

gtgatcattt ggatctggag gcagagtctg ccattctgcc agactagcaa tttgggggct     1440

tactcatgct aggcttgagg aagaagaaaa acgcttcggc attctcctta ggacttatct     1500

gcttgtagat ttggctgatc caattaacat gtggggttct tggtgtgggt ctggggagct     1560

gaaggatttt atggagctgg tgctttggag gaatcttaag ggaaaggagt agaagctcag     1620

gcctttgaag gatttcagct cctcctctct gtaatttgtg ctttaagcat tttttttcct     1680

aaaataaact caaatttatc ctcaa                                           1705


<210> 302
<211> 1742
<212> DNA
<213> Homo sapiens

<400> 302
ggtggtggca gaggcgcctg cggttactgg ccgggccgac gggtcctgag tctccagagc       60

tcggtgaggc gtcccggagg cggcgatcac ggttcttaca tccccgcgtc cccaggttta      120

gcctgagcag ggttgtggaa ggccgggacc cattgacagc acgatggtga cggagcagga      180

ggtggatgcc atcgggcaga cgctggtgga ccccaagcag cccctgcagg cccgcttccg      240

ggcgctgttc acgctgcgtg ggctcggcgg cccaggcgcc attgcatgga tcagccaggc      300

cttcgatgac gattccgccc tgctcaagca cgagctggcc tactgcctgg gccagatgca      360

ggatgcccgc gccatcccca tgctggtgga cgtgctgcaa gacacccgtc aggagcccat      420

ggtgcgccat gaggcagggg aggccctggg ggccatcggg gacccggaag ttctggagat      480

cctgaagcag tattcctcgg accccgtcat cgaggtggcc gagacctgcc agctggccgt      540

gcgcaggctg gagtggctgc agcagcacgg cggggagccg gcggcgggac cctacctctc      600

cgtggaccct gccccgccgg ctgaggagcg tgacgtgggg cgcctgcggg aggcgctgct      660

ggatgagtcc cggccgctct tcgagcgata ccgcgccatg ttcgccctgc gcaacgcggg      720

aggcgaggag gccgccctgg cgctggccga gggtctgcac tgtgggagcg ccctcttccg      780

ccacgaggtc ggctacgtcc tgggacagct gcagcacgag gcggcggtgc cccagctggc      840

ggccgccctg gcccgatgca ccgagaaccc catggtgcgg cacgagtgcg cggaggccct      900

gggcgccatt gcccggcccg cctgcctggc cgcgctgcag gctcacgcgg acgacccaga      960

gcgcgtggtg cgtgagagct gcgaggtggc tctggacatg tatgagcacg agaccgggcg     1020

ggccttccag tacgcggacg gcctggagca gctgcgcggg gccccctcct agggccccac     1080

cctcacccgg agctcccgga ggactcttga gggccgctcc tcccccgcag agctttggcg     1140

tctaaaccgg gtgtgtgtaa atcggtgtca tcgcttgtgt cttgctgggc gcatggttgc     1200

tgtccccctc ctccgtctgg gaccgaggag ctgccgttgt gctgtgactc cctgagtccc     1260

ctgactgctc ctcggggcct ggcgcagggc tgtagcgtgg aagtttccag gcttggggtg     1320

ggactctgcg ggaggctctg ggatgcccgg ctcaggacag gggaggattg cgagggaagc     1380

caggggagga tcgcgaggga agccagggga ggatcgcgag ggaagccagg ggaggatcgc     1440

gagggaagcc aggggaggat cgcgagggaa gccaagggag gatcgcgagg ggagccaggg     1500

gaggatcgcg agggaagcca ggggcagagc tggggctctg ggaagaggct gacgttatgg     1560

tggcttcagc ttcactagga atgggacaca gggtctgggg gcctctgact cccccacccc     1620

gaggcctggg tagggacagg gtggtggtcc ctgagtgggt caggtagggc acaggggcca     1680

gggagggaca agcagacctc agagcgctgc ccagatggaa tattaaatta tttttgccaa     1740

gc                                                                    1742


<210> 303
<211> 4483
<212> DNA
<213> Homo sapiens

<400> 303
gtcggtgcct gcagggctct ccgtggccgc tcgggagagg tgctcttcgc tcaggctccc       60

ccggagactt gagggggtgc gcgctggcgt gcatggggcc tgttctgtcc ttggtttggg      120

gatgctccta aggggggaga aagggatacc tcgggtgctt ggaggtcgag agacggatac      180

gtaagtgcgc aagggccact gattagggca cgggaagggc tcgctagaat gagctcttaa      240

actggttggg tgtaagcggt tttgggctag tctaaaccaa acaactgaga ataaacgcgg      300

ggttcctgca ggttgagaga gtacctgtct gcaaatgtcc agtagtgatg gattgccttg      360

taggccccag agcaatcggg gaagttagca ttcttgttca agaagctgct ggttcactta      420

gagctataaa agaatgttgt gagtttggat tttcttccaa acgttcagga ttgaggttag      480

ggctggtggt gagggatcat gtaaagaggt ttgagtggct cagccttagg tcccggtgtg      540

gaaagcttat tcttttggtg tcatcacgtg gccgtgggaa ttatttagaa tgtgatctgc      600

cctcatgaga agaaaggagc tctgaagccg ttgcagttct tcctccctat gtggaaaatc      660

gaatttctgg aaacatcctc cgtattggga gattttgcct atgtaaaggc tatccttatt      720

ggctagcggc actaattact ttaaaagtag gatggaagta caagtatctc aagcatcatt      780

gggtttcgag ctcacttctg tggaaaagag tttaagggag tggtctagac tttccaggga      840

agttattgcc tggctgtgtc cctctagtcc taattttata cttaactttc ccccacctcc      900

ttcagcctca tctgtttcaa tggtgcaact cttttcatcc ccttttggtt accagtcacc      960

ttcaggccat tcagaggagg aaagagaggg gaatatgaag tcagccaagc cccaagtgaa     1020

ccacagtcag catggggaaa gccagcgggc cttgagcccc ctgcagtcta ctctgagttc     1080

tgctgcatct ccttcccaag cgtatgagac ctatattgaa aatggactca tatgccttaa     1140

acacaaaatt agaaacatcg agaaaaagaa gctcaaactg gaggattata aggatcgcct     1200

gaaaagtgga gagcatctta atccagacca gttggaagct gtagagaaat atgaagaagt     1260

gctacataat ttggaatttg ccaaggagct tcaaaaaacc ttttctgggt tgagcctaga     1320

tctactaaaa gcgcaaaaga aggcccagag aagggagcac atgctaaaac ttgaggctga     1380

gaagaaaaag cttcgaacta tacttcaagt tcagtatgta ttgcagaact tgacacagga     1440

gcacgtacaa aaagacttca aagggggttt gaatggtgca gtgtatttgc cttcaaaaga     1500

acttgactac ctcattaagt tttcaaaact gacctgccct gaaagaaatg aaagtctgag     1560

tgttgaagac cagatggagc agtcatcctt gtacttttgg gaccttttgg aaggtagtga     1620

gaaagcagtg gtaggaacga catacaaaca cttgaaggat ctactgtcta aattgctgaa     1680

ctcaggctat tttgaaagta tcccagttcc caaaaatgcc aaggaaaagg aagtaccact     1740

ggaggaagaa atgctaatac aatcagagaa aaaaacacaa ttatcgaaga ctgaatctgt     1800

caaagagtca gagtctctaa tggaatttgc ccagccagag atacaaccac aagagtttct     1860

taacagacgc tatatgacag aagtagatta ttcaaacaaa caaggcgaag agcaaccttg     1920

ggaagcagat tatgctagaa aaccaaatct cccaaaacgt tgggatatgc ttactgaacc     1980

agatggtcaa gagaagaaac aggagtcctt taagtcctgg gaggcttctg gtaagcacca     2040

ggaggtatcc aagcctgcag tttccttaga acagaggaaa caagacacct caaaactcag     2100

gtctactctg ccggaagagc agaagaagca ggagatctcc aaatccaagc catctcctag     2160

ccagtggaag caagatacac ctaaatccaa agcagggtat gttcaagagg aacaaaagaa     2220

acaggagaca ccaaagctgt ggccagttca gctgcagaaa gaacaagatc caaagaagca     2280

aactccaaag tcttggacac cttccatgca gagcgaacag aacaccacca agtcatggac     2340

cactcccatg tgtgaagaac aggattcaaa acagccagag actccaaaat cctgggaaaa     2400

caatgttgag agtcaaaaac actctttaac atcacagtca cagatttctc caaagtcctg     2460

gggagtagct acagcaagcc tcataccaaa tgaccagctg ctgcccagga agttgaacac     2520

agaacccaaa gatgtgccta agcctgtgca tcagcctgta ggttcttcct ctacccttcc     2580

gaaggatcca gtattgagga aagaaaaact gcaggatctg atgactcaga ttcaaggaac     2640

ttgtaacttt atgcaagagt ctgttcttga ctttgacaaa ccttcaagtg caattccaac     2700

gtcacaaccg ccttcagcta ctccaggtag ccccgtagca tctaaagaac aaaatctgtc     2760

cagtcaaagt gattttcttc aagagccgtt acaggctact tcttctccag ttacttgtag     2820

ctcaaatgct tgcttggtta ctaccgatca ggcttcttct ggatctgaaa cagagtttat     2880

gacctcagag actcctgagg cagcaattcc cccaggcaag caaccgtctt cactagcttc     2940

tccaaatcct cccatggcaa agggctctga acagggcttc cagtcacctc cagcaagtag     3000

tagttcagta accattaaca cagcaccctt tcaagccatg cagacagtat ttaacgttaa     3060

tgcacctctg cctccacgaa aagaacaaga aataaaagaa tccccttatt cacctggcta     3120

caatcaaagt tttaccacag caagtacaca aacaccaccc cagtgccaac tgccatctat     3180

acatgtagaa caaactgtcc attctcaaga gactgcagca aattatcatc ctgatggaac     3240

tattcaagta agcaatggta gccttgcctt ttacccagca cagacgaatg tgtttcccag     3300

acctactcag ccatttgtca atagccgggg atctgttaga ggatgtactc gtggtgggag     3360

attaataacc aattcctatc ggtcccctgg tggttataaa ggttttgata cttatagagg     3420

actcccttca atttccaatg gaaattatag ccagctgcag ttccaagcta gagagtattc     3480

tggagcacct tattcccaaa gggataattt ccagcagtgt tataagcgag gagggacatc     3540

tggtggtcca cgagcaaatt cgagagcagg gtggagtgat tcttctcagg tgagcagccc     3600

agaaagagac aacgaaacct ttaacagtgg tgactctgga caaggagact cccgtagcat     3660

gacccctgtg gatgtgccag tgacaaatcc agcagccacc atactgccag tacacgtcta     3720

ccctctgcct cagcagatgc gagttgcctt ctcagcagcc agaacctcta atctggcccc     3780

tggaacttta gaccaaccta ttgtgtttga tcttcttctg aacaacttag gagaaacttt     3840

tgatcttcag cttggtagat ttaattgccc agtgaatggc acttacgttt tcatttttca     3900

catgctaaag ctggcagtga atgtgccact gtatgtcaac ctcatgaaga atgaagaggt     3960

cttggtatca gcctatgcca atgatggtgc tccagaccat gaaactgcta gcaatcatgc     4020

aattcttcag ctcttccagg gagaccagat atggttacgt ctgcacaggg gagcaattta     4080

tggaagtagc tggaaatatt ctacgttttc aggctatctt ctttatcaag attgaaagtc     4140

agtacagtat tgacaataaa aggatggtgt tctaattagt gggattgaag gaaaagtagt     4200

ctttgccctc atgactgatt ggtttaggaa aatgtttttg ttcctagagg gaggaggtcc     4260

ttactttttt gttttccttc ctgaggtgaa aaatcaagct gaatgacaat tagcactaat     4320

ctggcacttt ataaattgtg atgtagcctc gctagtcaag ctgtgaatgt atattgtttg     4380

cacttaatcc ttaactgtat taacgttcag cttactaaac tgactgcctc aagtccaggc     4440

aagttacaat gccttgttgt gcctcaataa aaaagttaca tgc                       4483


<210> 304
<211> 2899
<212> DNA
<213> Homo sapiens

<400> 304
ctcagttccc tccgccctcc tcgggctcca gcggtggcgg agcgaacggg accggcccgg       60

cttcagagcg cgaggtggag ggtggaacgc gggcgcctga aggagttgtt gtctcggcag      120

cgcccgcgga gacgtgaaga ggtggttgtg ggaagagaag tttgcagaac tgaaatggag      180

gtcagagctt cattacagaa ggttagtgga tcatctgatt ctgtggctac aatgaacagt      240

gaagaatttg ttttggttcc tcagtatgca gatgataatt ctacaaaaca tgaagaaaaa      300

cctcaactga agatagtttc taatggtgat gaacaattgg aaaaagccat ggaagagatt      360

ttgagagatt ccgagaaaag gccaagcagt cttcttgttg attgtcaaag ttccagtgag      420

atttcagacc attcgtttgg agatattcca gccagccaaa caaataagcc atctcttcag      480

ttaattttgg atccgtctaa cacagaaatt tctacaccca gaccatcttc tccaggtgga      540

ctacctgaag aagatagtgt tttatttaat aaactgacct acttaggatg tatgaaggtt      600

tcttccccac gtaatgaagt agaggcttta cgggcaatgg caaccatgaa atcttccagt      660

caatacccct ttcctgttac cctgtatgta ccaaatgttc cagaaggttc tgtgagaatt      720

atagaccaat ccagcaatgt ggagatagca tcttttccaa tctataaggt gttattctgt      780

gcacgtggac atgacggaac aacagagagc aattgctttg catttacaga gagttcccat      840

ggttcggaag aatttcagat acatgttttc tcctgtgaaa ttaaagaggc agtaagcaga      900

attttgtaca gtttctgtac agcattcaaa cgttcttcca gacaagtgtc tgatgttaaa      960

gactcagtta ttcctacccc cgacagtgat gtgtttacct tcagtgtctc cttggaggta     1020

aaagaagacg atggaaaagg aaactttagc cctgtgccta aggatagaga taaattttat     1080

ttcaaattaa agcaaggaat agagaagaag gttgtgatta cagtgcagca actttctaac     1140

aaagaattag ctattgaaag atgttttgga atgttattaa gcccaggtcg aaacgtgaag     1200

aacagtgaca tgcatttact ggatatggaa tccatgggaa agagctatga tgggagagct     1260

tatgtcatca ctggcatgtg gaaccccaat gcaccagtat ttctggcact taacgaggaa     1320

accccaaaag ataagcaagt atacatgact gtggcagtgg atatggtagt cacagaggtg     1380

gtggagcctg ttcgctttct cctggagaca gtagtccgtg tgtaccctgc aaatgagcga     1440

ttttggtatt tcagcagaaa gactttcaca gagactttct tcatgagatt gaaacagtct     1500

gagggaaaag gccataccaa tgctggagat gcaatatatg aggtggtgag tctacagcga     1560

gagtctgaca aggaggaacc agtcactcct actagtggag ggggtccaat gtcaccccag     1620

gatgatgaag cagaagagga gagtgataat gaactctcaa gtggaacagg tgatgtgtct     1680

aaggattgtc ctgagaagat cctgtattct tggggagagt tgctaggaaa atggcacagt     1740

aaccttggtg cacgaccgaa agggctgtct actctggtga agagtggtgt ccctgaagca     1800

ttgagggcag aggtatggca gttattggca ggctgccatg acaaccaggc aatgctggat     1860

agataccgaa ttcttatcac aaaggactca gcccaggaga gtgttattac tcgagatatt     1920

catcgtacat ttcccgcaca tgattacttt aaagatactg gaggagatgg tcaagaatcg     1980

ctctataaga tctgcaaggc ctactctgtg tatgatgaag acattgggta ctgtcaaggg     2040

cagtcttttc ttgctgctgt attactgctg catatgccag aggaacaagc attctgtgtt     2100

ttggtgaaaa tcatgtacga ctatggtttg agagacctct acagaaacaa cttcgaagat     2160

cttcattgca aattctacca gttggagaga ctaatgcagg aacagctacc ggacctgcat     2220

agccattttt ctgatctgaa cctggaagct catatgtatg catcccagtg gtttctcact     2280

ctttttactg ccaagttccc actctgcatg gtgttccaca tcattgactt actgctttgt     2340

gagggtttga acataatctt tcatgtagct ttggctctcc taaagacctc aaaggaagac     2400

cttctgcagg ctgattttga aggtgcttta aagttcttta gagttcagct tccaaagaga     2460

tacagggcag aggaaaatgc aagaagactg atggagcagg cttgcaatat taaagtacca     2520

accaagaagc tgaagaaata tgagaaagaa tatcagacaa tgcgagagag tcagctgcaa     2580

caggaagacc caatggatag atacaagttt gtatatttgt aggtaactcc agctgttgca     2640

tttatactgg gaatcttcat aagaagctga gagaaagaga ggggaaaaag aaagtggctt     2700

tctactttca aaaatgaaac aaaaaggaaa aatggcaaag tactgtttta gctgtgcatg     2760

tcatatccac aaagactttt agcaggtgaa ctgttccaag actgacacaa ggatgtttca     2820

aacttgcctc tgtctgtaga aaatgttaaa aataccaact cacttggaag gaaaaataaa     2880

aatcacaaag gtatattga                                                  2899


<210> 305
<211> 1026
<212> DNA
<213> Homo sapiens

<400> 305
tggcagcgga gcccgcgcag ggtttgccag gcgaaggcgg agcgctaacg tctaacgcta       60

acggcggtcg tgccccgccg ctgctgtcac ccccggccgc tgctgccctc cccgccgagg      120

ttctactgct ctccttctta agaagggtgg gaggcactcg gtctctcccc acacctctcg      180

cctgaggcca ggcgccaggt gtcgcctgaa gccagacagc cggtttggga gcgagcctga      240

ggtcaaccaa tcaatggctc agacagataa gccaacatgc atcccgccgg agctgccgaa      300

aatgctgaag gagtttgcca aagccgccat tcgggcgcag ccgcaggacc tcatccagtg      360

gggggccgat tattttgagg ccctgtcccg tggagagacg cctccggtga gagagcggtc      420

tgagcgagtc gctttgtgta actgggcaga gctaacacct gagctgttaa agatcctgca      480

ttctcaggtt gctggcagac tgatcatccg tgcagaggag ctggcccaga tgtggaaagt      540

ggtgaatctc ccaacagatc tgtttaatag tgtgatgaat gtgggtcgct tcacggagga      600

gatcgagtgg ctgaagtttt tagcccttgc ttgcagcgct ctgggagtta ctattaccaa      660

aactctcaag atagtgtgtg aggtcttatc atgtgaccac aatggtgggt tgccccgaat      720

cccattcagc accttccagt ttctctacac gtatattgcc gaagtggatg gggagatctg      780

tgcatcacat gtcagcagga tgctaaacta cattgaacag gaagtaattg gtcctgatgg      840

tttaatcacg gtgaatgact ttacccaaaa ccccagggtt tggctggagt aacagcacaa      900

ttttggcaat tttaaaggaa gatacagagg tgattgtact tcagaatgat aaacccatat      960

accacctaaa atcaattttc ttgtacaact ggtacacact aataaacaaa catgtgagat     1020

cagaaa                                                                1026


<210> 306
<211> 2176
<212> DNA
<213> Homo sapiens

<400> 306
agtcacagca gccagctgct gtagaagagg ggaggaaaca agccagtgca aggggagcaa       60

aagagaaaag gagccaggct gggcttcctg atcccacagc atcgcagagc tcgggaggca      120

cagctcacag acacaggaaa cacaggactg ctattctgct ctcctgccca cggtgatctg      180

gtgccagctg gtggaacagt gggtgatggc gtccctgctg caagaccagc tgaccactga      240

tcaggacttg ctgctgatgc aggaaggcat gccgatgcgc aaggtgaggt ccaaaagctg      300

gaagaagcta agatacttca gacttcagaa tgacggcatg acagtctggc atgcacggca      360

ggccaggggc agtgccaagc ccagcttctc aatctctgat gtggagacaa tacgtaatgg      420

ccatgattcc gagttgctgc gtagcctggc agaggagctc cccctggagc agggcttcac      480

cattgtcttc catggccgcc gctccaacct ggacctgatg gccaacagtg ttgaggaggc      540

ccagatatgg atgcgagggc tccagctgtt ggtggatctt gtcaccagca tggaccatca      600

ggagcgcctg gaccaatggc tgagcgattg gtttcaacgt ggagacaaaa atcaggatgg      660

taagatgagt ttccaagaag ttcagcggtt attgcaccta atgaatgtgg aaatggacca      720

agaatatgcc ttcagtcttt ttcaggcagc agacacgtcc cagtctggaa ccctggaagg      780

agaagaattc gtacagttct ataaggcatt gactaaacgt gctgaggtgc aggaactgtt      840

tgaaagtttt tcagctgatg ggcagaagct gactctgctg gaatttttgg atttcctcca      900

agaggagcag aaggagagag actgcacctc tgagcttgct ctggaactca ttgaccgcta      960

tgaaccttca gacagtggca aactgcggca tgtgctgagt atggatggct tcctcagcta     1020

cctctgctct aaggatggag acatcttcaa cccagcctgc ctccccatct atcaggatat     1080

gactcaaccc ctgaaccact acttcatctg ctcttctcat aacacctacc tagtggggga     1140

ccagctttgt ggccagagca gcgtcgaggg atatatacgg gccctgaagc gggggtgccg     1200

ctgcgtggag gtggatgtat gggatggacc tagcggggaa cctgtcgttt accacggaca     1260

caccctgacc tcccgcatcc tgttcaaaga tgtcgtggcc acagtagcac agtatgcctt     1320

ccagacatca gactacccag tcatcttgtc cctggagacc cactgcagct gggagcagca     1380

gcagaccatg gcccgtcatc tgactgagat cctgggggag cagctgctga gcaccacctt     1440

ggatggggtg ctgcccactc agctgccctc gcctgaggag cttcggagga agatcctggt     1500

gaaggggaag aagttaacac ttgaggaaga cctggaatat gaggaagagg aagcagaacc     1560

tgagttggaa gagtcagaat tggcgctgga gtcccagttt gagactgagc ctgagcccca     1620

ggagcagaac cttcagaata aggacaaaaa gaagaaatcc aagcccatct tgtgtccagc     1680

cctctcttcc ctggttatct acttgaagtc tgtctcattc cgcagcttca cacattcaaa     1740

ggagcactac cacttctacg agatatcatc tttctctgaa accaaggcca agcgcctcat     1800

caaggaggct ggcaatgagt ttgtgcagca caatacttgg cagttaagcc gtgtgtatcc     1860

cagcggcctg aggacagact cttccaacta caacccccag gaactctgga atgcaggctg     1920

ccagatggtg gccatgaata tgcagactgc agggcttgaa atggacatct gtgatgggca     1980

tttccgccag aatggcggct gtggctatgt gctgaagcca gacttcctgc gtgatatcca     2040

gagttctttc caccctgaga agcccatcag ccctttcaaa gcccagactc tctcaatccc     2100

ataccgacat ctacaactaa tctttcccat caactctgtg tgaaggcagg ttgcaactag     2160

aaattcagag gggctt                                                     2176


<210> 307
<211> 7780
<212> DNA
<213> Homo sapiens

<400> 307
agctctgagg aggcggggcc aggacggcgg gaccggccgc tgggtcccag cgagggctga       60

gccgggcggt gggaggaggt caggatggtg ggggaacggc atgctgggga cctcatggtg      120

cccttagggc ctcggctgca ggcatatcct gaagaactca ttcgacagag gcctgggcat      180

gacgggcatc ctgaatacct gatccgatgg agtgtcctga agtgtgggga agtgggcaaa      240

gtgggtgtgg aagaaggcaa agcagagcac atcctcatgt ggctgtcggc tcctgaggtc      300

tacgccaact gccctgggct gttaggtgag cgggcactat ctaagggact tcagcacgaa      360

ccagctgggg tttcaggaag ctttcctcga gatccaggag gcctggatga agtggcaatg      420

ggagagatgg aggctgatgt tcaggcgctg gtacgcaggg cggccaggca gctggcagaa      480

agtgggaccc caagcctcac ggccgctgtg cttcacacca tccacgtgct cagtgcctac      540

gccagcatcg ggcccctcac tggtgtcttc agggagacag gagccctgga cctgctcatg      600

cacatgttat gcaatcctga gcctcagatc cgccggagtg caggcaaaat gctgcaggct      660

ctggcagccc acgatgctgg gagtcgggct cacgtccttc tatcactgag ccagcaagat      720

ggcatcgagc agcacatgga ttttgacagt cgctatacat tgctggagct gtttgcagaa      780

accacatcct ctgaagaaca ctgcatggcc tttgagggca ttcatctgcc tcagatccca      840

ggaaagctgc ttttctcctt ggtgaagcgc tacctttgtg tcacgtccct cctggatcag      900

ctgaatagca gtccagagct gggagctgga gaccaaagct ccccatgtgc cacaagagag      960

aaaagccggg gacagcggga actggagttc agcatggctg tgggcaacct catctctgag     1020

cttgtgcgga gcatgggctg ggcccggaac ctcagcgaac agggcatgtc acctccccgg     1080

ccaacccggt ccatctttca gccctacatt tcaggcccca gccttttact ccccaccatt     1140

gtcaccaccc ccagaagaca agggtgggtc ttccgccagc gctctgaatt ctccagccgt     1200

agtggctatg gagaatatgt gcagcagaca ctccagccag ggatgcgagt gcggatgctg     1260

gatgattatg aggagatcag tgctggggac gagggcgagt tccggcagag caacaacggc     1320

attccccctg tgcaggtttt ctggcagtcg acaggccgca cttactgggt gcactggcac     1380

atgctggaga tcctgggccc tgaggaagcc actgaggata aggcttcagc agctgtggag     1440

aagggggcag gggctactgt gttgggcaca gcatttccct cctgggactg gaatcctatg     1500

gatgggctgt accctttgcc gtacctccag cccgaacctc agaagaatga gagagtggga     1560

tatctgaccc aggctgaatg gtgggagctg cttttcttta tcaaaaagtt ggacttgtgt     1620

gagcagcagc caattttcca gaatctttgg aagaacctgg atgagaccct gggtgaaaag     1680

gccctaggtg agatctctgt gtccgtggaa atggccgaga gtctgctgca ggttctcagt     1740

agtcgatttg agggcagcac tctcaatgac ctgctcaact cccagatcta caccaagtat     1800

gggctgctgt ctaatgaacc aagcagctcg tctacttcac gaaatcactc ctgtacccca     1860

gatccagaag aggagtccaa gtcggaggcc agcttctcag aggaagagac tgagtccctc     1920

aaagcaaagg ccgaggcccc taagacagag gccgagccca ccaagacaag gaccgagacc     1980

cccatggcac agagtgattc tcagctgttt aaccagcttc tggtgactga ggggatgacc     2040

ctgcccactg agatgaagga ggcagccagt gaaatggcca gagccttgcg gggtcccggt     2100

cctcgcagct ccctggatca gcatgtggca gcggtcgtgg ccactgtgca gatatccagc     2160

ttggacacaa acctgcagct ttcagggctc tctgccctct ctcaggctgt ggaggaggtc     2220

actgagcggg accaccctct ggtccgtcct gacagatcgc tgagagagaa gctagtgaag     2280

atgctggtgg agctgctgac caaccaggtg ggagagaaga tggtggtcgt gcaggccctg     2340

cgcctccttt acctgctcat gaccaagcac gagtggcggc cgctctttgc cagggagggt     2400

ggcatctatg ctgtgctggt ctgcatgcaa gaatataaga cttctgtctt ggtgcagcag     2460

gctgggctgg cggcactgaa gatgctggcc gtcgccagct cctcggagat ccccactttt     2520

gttactggcc gagattctat ccactctttg tttgatgctc agatgaccag agagatcttc     2580

gccagcatcg actcagccac acgcccgggc tctgagagcc tgctcctcac tgtccctgca     2640

gccgtgatcc tgatgctgaa tactgagggg tgctcttctg cagcgagaaa tggcttactc     2700

ctgctcaacc tacttttgtg caaccaccac actctgggag accagattat aacccaagag     2760

ctgagagaca cgttgtttag gcactcaggg atagcaccaa gaacagaacc tatgcctacc     2820

acacgcacca tcctcatgat gcttctcaat cgctactcag agccgccggg cagccctgag     2880

cgtgcagcac tagagacccc catcatccag ggtcaggatg ggtcccctga gctactgatt     2940

cgatccctgg ttgggggccc atctgcagaa ctactcctgg acttggagcg tgtgctgtgc     3000

cgtgagggca gccccggagg tgccgtgagg cccctcctca agcgcctcca gcaggagacc     3060

cagcctttcc tcctgttgct gcggactctg gatgctccgg ggcccaacaa gactctgctg     3120

ctgtctgtgc tgagggtcat aacccgactg ctggatttcc ctgaggcaat ggtcctcccc     3180

tggcacgagg tcttggagcc ctgcctcaac tgcctgagtg gccctagcag tgactccgag     3240

attgttcagg agctgacctg cttcctacat cgcctggcct cgatgcataa ggactatgct     3300

gtggtgctct gctgcctggg agcaaaagag atcctctcca aagtcctgga caagcactca     3360

gctcagctgc tgctgggctg tgagcttcgg gacctggtga cagagtgtga gaagtacgca     3420

cagctctata gcaacctcac ctccagcatc ctggccggct gcattcagat ggtgctgggc     3480

cagatcgaag accacagacg aacccaccaa cccatcaata tccccttctt tgatgtgttc     3540

ctcaggcatc tctgccaggg ctccagtgtg gaagtgaagg aggacaagtg ctgggagaag     3600

gtggaggtgt cctccaaccc gcaccgagcc agcaagctga cggaccacaa ccccaagacc     3660

tactgggagt ccaacggcag caccggctcc cactacatca ccctgcacat gcaccgtggt     3720

gttcttgtta ggcagctcac tttgctggtg gccagtgagg actcaagcta catgccagcc     3780

agggtggtgg tgtttggggg tgacagcacc agctgcatcg gcactgagct caacacggtg     3840

aatgtgatgc cctctgccag ccgggtgatc ctcttggaga acctgaaccg cttctggccc     3900

atcatccaga tccgcataaa gcgctgccag cagggcggca ttgacacccg ggttcggggt     3960

gtggaggtcc tgggccctaa gcccacattc tggccactgt tccgggagca gctgtgtcgc     4020

cgaacatgtc tcttctacac aattcgggca caagcctgga gccgggacat agcagaggac     4080

caccggcgcc tcctccagct ctgtcccaga ctgaacaggg ttttgcgcca cgagcagaat     4140

tttgctgacc gcttcctccc tgatgatgag gccgcccagg cactgggcaa gacctgctgg     4200

gaggccctgg tcagccccct ggtgcagaac atcacctctc ccgatgcgga aggcgtgagt     4260

gccctgggat ggctgctgga tcagtactta gaacagagag agacctctcg gaaccccttg     4320

agtcgagcag cgtcctttgc ttctcgagtt cgtcgccttt gccacttgct ggtgcatgtg     4380

gaacctcctc ctgggccttc tcctgagcca tccactcggc ccttcagcaa gaacagcaag     4440

ggtcgggacc ggagcccggc gccttcgcca gtgcttccaa gcagcagcct gaggaacata     4500

acccagtgct ggctgagcgt ggtgcaggag caggtcagca gattcctggc tgcagcttgg     4560

agggccccag actttgtgcc tcgttactgt aaactctatg agcacttgca gagagcaggc     4620

tccgagctgt ttgggcctcg ggcagccttc atgctggctc tgcgcagtgg cttctctggc     4680

gccttgctgc agcagtcctt cctcactgct gctcacatga gtgagcagtt tgccaggtac     4740

attgaccaac agatccaggg tggcctgatt ggtggagccc ctggagtgga aatgctgggg     4800

cagcttcagc ggcacctgga acccattatg gtcctttctg gtctggaact ggccacaact     4860

tttgagcact tctatcagca ttatatggcg gaccgtctcc tgagctttgg ttcgagctgg     4920

ctggaggggg ctgtgctaga gcagattggc ctctgttttc ccaaccgcct cccacagctg     4980

atgctgcaga gcctgagcac ctctgaggag ctgcagcgcc agttccacct cttccagctc     5040

cagcggctcg acaagttgtt cttggagcag gaagatgagg aggaaaagag actagaggaa     5100

gaggaggagg aagaggagga agaggaagct gagaaagaat tatttatcga agatccaagt     5160

ccagccattt ctatactggt cctgtcacca cgctgctggc ccgtctcccc actctgctac     5220

ctgtaccatc ccagaaagtg ccttcccaca gaattctgtg atgcccttga ccgtttctcc     5280

agtttctaca gccagagtca gaaccatcca gtcctggaca tgggaccaca tcggcgactg     5340

cagtggacgt ggctgggccg ggctgagctg cagtttggga agcagatact gcatgtgtcc     5400

accgtgcaga tgtggctgct gctgaaattc aatcagacag aggaggtgtc agtagagacc     5460

ttgctgaagg attctgacct ctccccagag ctgctgctcc aggcactcgt gcccctcacc     5520

tcagggaatg gccctttgac cctgcatgag ggccaggact ttccacacgg gggtgtgctg     5580

cggcttcatg agcctgggcc ccagcgcagt ggggaggccc tgtggctgat acctccccag     5640

gcatacctga acgtagagaa ggatgaaggc cgaaccctgg aacagaagag gaatctcttg     5700

agctgtcttc ttgttcgtat tctcaaagcc catggggaaa agggcctcca cattgatcag     5760

ctggtttgtc tggtgctgga ggcctggcag aagggtccaa atcctcctgg aaccctgggc     5820

cacactgttg ctgggggtgt ggcctgtacc agtacagatg tcctctcttg catcctgcac     5880

ctcttaggcc agggctacgt gaaacggcgt gatgaccggc cccagatcct gatgtatgcc     5940

gctccagagc ccatggggcc ctgccggggt caggcagatg tccctttctg tggcagccag     6000

agcgaaacct ccaagcccag cccagaagct gtggctaccc tggcatctct acagctgcct     6060

gcaggccgca ccatgagccc ccaggaagta gaagggttga tgaagcagac ggtgcgtcag     6120

gtgcaggaga cgctgaactt agagccagat gtcgctcagc accttttggc tcattcccac     6180

tggggcgctg aacagctgct gcagagctac agtgaggacc ctgagccact gctgctggca     6240

gctgggctgt gcgtacacca ggctcaggct gtacccgtac ggcctgacca ctgccccgtc     6300

tgtgtgagcc ccctggggtg tgacgacgac ctgccctctc tctgctgcat gcactattgc     6360

tgtaagtctt gctggaatga gtacctgaca actcggatcg agcagaacct tgttttgaat     6420

tgcacctgcc ccattgccga ctgccccgcc cagcccaccg gagccttcat tcgtgccatc     6480

gtctcctcgc cagaggtcat ctccaagtat gagaaggcgc tcctgcgtgg ctatgtggag     6540

agctgctcca acctgacctg gtgcaccaac ccccagggct gcgaccgcat cctgtgccgc     6600

cagggcctgg gctgtgggac cacctgctcc aagtgtggct gggcctcttg cttcaactgt     6660

agcttccctg aggcacacta ccctgctagc tgtggccata tgtctcagtg ggtcgacgac     6720

ggtggctact atgacggcat gagcgtggag gcgcagagca agcacctggc caagctcatc     6780

tccaagcgct gtcccagctg tcaggctccc atcgagaaga acgaggggtg cctgcacatg     6840

acctgtgcca aatgtaacca tggattctgc tggcgctgcc tcaagtcctg gaagccaaat     6900

cacaaagact attacaactg ctctgccatg gtaagcaagg cagctcgcca ggagaagcgg     6960

tttcaggact ataatgagag gtgcactttc catcaccagg cgcgggagtt tgctgtgaac     7020

ttgcggaacc gggtgtctgc catccatgaa gtgcccccgc ccagatcctt caccttcctc     7080

aatgatgcct gccagggact ggagcaggct cggaaggtgc tggcctacgc ctgcgtgtac     7140

agcttctaca gccaggacgc agagtacatg gatgtggtgg agcagcagac agagaacctg     7200

gagctgcaca ccaatgccct gcagatcctc ctggaggaaa ccctgctgcg gtgcagagac     7260

ctggcctcct ccctgcgcct cctgcgggcc gactgcctca gcacgggcat ggagctgctc     7320

cggcggatcc aggagaggct gcttgccatc ctgcagcatt ctgcccagga tttccgggtt     7380

ggtcttcaga gtccatcagt agaggcctgg gaggcaaaag gacccaacat gcctggcagt     7440

cagccccagg cctcctcagg gccagaggca gaagaggagg aggaagacga tgaggatgat     7500

gtgcccgagt ggcagcagga tgagtttgat gaggagctgg acaatgacag cttctcctac     7560

gatgagtctg agaacctgga ccaagagact ttcttctttg gtgatgagga agaggatgaa     7620

gatgaggcct atgactgagg gggcagatgc aggaaacacc tagagcagcc ccagagtcac     7680

ggggctgagg gggcgggagc tgcccctgtc atagggaggg ggattcccag cgtctgtagt     7740

gcttcctgtt tgctgaataa aggtctcttt ctcacacaca                           7780


<210> 308
<211> 2535
<212> DNA
<213> Homo sapiens

<400> 308
cctcatccgg ggctctcacc cacatccggg accctcatgc ctgggcggag gagggggggc       60

cctcattcgg gaccctgcac tccgtcgccg gaagtgccac cgagaagcgc cggcctcggg      120

gctgtctaca gcggcccggg agaggctgtg gtggccccga gcgcgagtgt gtaggtgaca      180

ggacagcggc caggcccgcc cctcccctcg tgatggtcat tgtcctccag agcagtgatg      240

gaggaaatac cagcccagga agcagcaggg tcaccaaggg tccagtttca gtctttggag      300

acccagtctg agtgtctgtc cccagagcct cagtttgtgc aggacaccga catggaacag      360

ggactcactg gggatggaga gaccagagaa gagaacaagc tgttgattcc taagcagaaa      420

atttcggaag aagtgcattc atacaaagtg agagtaggaa gactcaaaca cgatattacc      480

caagttcctg agactagaga agtgtataag tctgaggaca gattagaaag acttcaggaa      540

attctaagga aatttctgta cctggagaga gagtttaggc aaataacaat cagcaaggaa      600

accttcacca gtgagaagaa caatgaatgt catgaacccg aaaaaagctt cagtctggac      660

tctactattg atgcagatca gagagttctt agaatacaga ataccgatga caatgataag      720

tatgacatga gcttcaacca gaattcagcc tctggtaaac atgaacactt aaatctaaca      780

gaggattttc agagtagtga atgtaaggaa agcttaatgg atctctccca ccttaataaa      840

tgggagagca tccctaacac tgagaaatcc tataaatgtg atgtatgtgg gaaaattttc      900

catcagagct cagcccttac tagacatcag agaatccata ctagagagaa gccctacaaa      960

tgtaaagaat gtgaaaagtc tttcagtcag agctcaagtc ttagtcgaca taaaagaata     1020

cacactagag aaaaacctta caaatgtgaa gcatctgata aatcctgtga agcgtctgat     1080

aaatcctgta gtccaagctc aggcataatt cagcataaga aaattcacac cagagccaaa     1140

tcttacaaat gtagcagttg tgaaagagtc ttcagtcgta gtgtccacct tactcaacat     1200

cagaaaattc acaaagagat gccctgtaag tgtactgtat gtggcagtga cttctgccat     1260

acttcatacc tacttgaaca tcagagggtc catcatgaag agaaagccta tgagtatgat     1320

gaatatgggt tggcctatat taaacaacaa ggaattcatt tcagagaaaa gccctatacg     1380

tgtagtgaat gtggaaaaga cttcagattg aattcacatc ttattcagca tcaaagaatt     1440

cacacaggag agaaagcaca tgaatgtaat gaatgtggaa aagctttcag tcaaacctca     1500

tgccttattc agcatcacaa aatgcatagg aaagagaaat cgtatgaatg taatgagtat     1560

gagggcagtt tcagtcatag ctcagatctt atcctgcaac aagaagtcct caccagacag     1620

aaagcctttg attgtgatgt atgggaaaag aactccagtc agagagcaca tctagttcaa     1680

catcagagca ttcataccaa agagaactca tgaatgtaat gaagatggga agatatttat     1740

caaattcagg cttcattcag catctgagag ttcacaccag ggagaaatca tgtatgtact     1800

gcatgtggta aagccttcag tcatagctca gccattgctc agcatcagat aattcacacc     1860

agagagaaac cctctgaatg tgacgaatga agaaaaggta ttagtgttaa actcttaatc     1920

gactcctgca aatctatacc agtgagaaat cttacaaatg tattgaatgt ggcaaatttt     1980

tcatgctatt agtattttca taccttagtc acatttggag aattcacatg ggaataaaat     2040

tccattgctg caatgaatgt gaaaaagcca tcagtcaaag aaactacctt gtttagtatc     2100

aaattcacgc catgcaaaaa gattataaat gtaataagca tgtatgtgtg tgaggagatt     2160

cagtcataac ccaacgctca ttcaacatca aagaatttat acctaagaga acttatttgg     2220

gtgtagtaaa tggcagatct ttcaatagga gtttaactag tctttgtcat atcagaatat     2280

ccatagtaga caagaatttg atgtaacgca aatggaaaaa ctcgacacca catttcaggc     2340

tttacccaac atcgaaataa tggagagaaa attgttgatt atttgtttat gaaattgtta     2400

atacatagtc ccaatctttt tcattgcaca aaaatctagg gttgacttgg taaatgcagt     2460

gacattttct catggagttc ctttatttaa tatgtattct aagtaggtac gtttattttt     2520

acttttttat tataa                                                      2535


<210> 309
<211> 2884
<212> DNA
<213> Homo sapiens

<400> 309
ggagaacata ttgtgatgtt cgtgcctcag agctaaaact atgagtgaat ttcggattca       60

ccatgacgtc aatgaactgc ttagcctgct gcgtgtccac ggaggagatg gggctgaggt      120

ctacattgac ctgcttcaaa agaacaggac cccgtacgtc actaccactg tctctgctca      180

cagtgccaag gttaaaattg cagagttttc tcgtactcca gaagactttc taaagaaata      240

tgatgaactg aaatctaaaa atacaaggaa ccttgacccg ctggtgtacc tgttgtcaaa      300

gctcacggaa gacaaagaga ctctgcagta cttacaacag aatgcaaaag aaagagctga      360

gcttgcagcc gctgctgtgg gcagcagtac caccagcatc aacgtccctg ccgcggcctc      420

caagatctcc atgcaggagc ttgaggaact gaggaagcag cttggcagcg tggccacagg      480

ctccacgctg cagcagtctc tggaacttaa aagaaagatg cttcgagaca agcagaacaa      540

aaaaaattca ggccagcacc tccccatctt cccagcatgg gtgtatgaga gacctgccct      600

gatcggggat ttcctgattg gtgctggcat cagcacagac accgctttgc cgataggcac      660

gttgcccctg gcctcgcagg agtcggccgt ggtggaggac ctgctgtacg tgctggtggg      720

cgtggacggg aggtacgtca gtgctcagcc cctggctggg aggcagagcc ggaccttcct      780

cgtggacccc aacctggacc tgtccatcag ggagctggtg cacaggatcc tcccagtggc      840

cgccagctac tccgctgtga ccaggttcat tgaagagaag tcttccttcg agtacgggca      900

ggtgaaccac gccctggcgg ccgccatgcg caccctggtg aaggagcacc tgattctggt      960

gtcacagctg gagcagctgc acaggcaggg cctcctttcg ctgcagaagc tctggttcta     1020

catccagcca gccatgcgca ccatggacat cctggcctcc ctcgccacct cggtggacaa     1080

aggcgaatgt cttggggggt ccacgctgag cctgctccac gacaggagct tcagctacac     1140

aggggacagc caggcgcagg agctatgcct gtacctaacc aaggcggcca gtgctcccta     1200

cttcgaggtt ctggagaagt ggatctacag gggcatcatc cacgacccat acagtgagtt     1260

tatggtcgag gagcacgagc tgcggaagga gaggatccag gaggattaca acgacaagta     1320

ctgggaccag cggtacacca tcgtccagca gcagatcccg tccttcctgc agaaaatggc     1380

ggacaagatc ctcagcacag gaaaatatct aaatgtggtc agagagtgtg gccatgacgt     1440

cacctgcccg gtggctaaag agatcatcta cacgttaaaa gagcgggcgt atgtggagca     1500

gatcgagaag gcgtttaact acgccagcaa ggtgctgctg gacttcctga tggaggagaa     1560

ggagctggtg gctcacctca ggtccatcaa gcgctacttc ctcatggacc agggcgactt     1620

cttcgtgcac ttcatggacc tcgcggagga ggagctccgg aagccggtgg aggacatcac     1680

gccccctcgc ctggaagcgc tcctggagct ggcgctgcgc atgagcacgg ccaacactga     1740

ccccttcaag gacgacctca agatcgacct gatgccccat gacctcatca ctcagctctt     1800

gcgcgtcctg gccatcgaga ccaagcagga gaaggcgatg gcgcacgccg accccacgga     1860

gctggcgctg agcggcctgg aggccttctc tttcgactac atcgtcaagt ggcccctttc     1920

gctcatcatc aacaggaaag ccctcactcg ctaccagatg ctcttcaggc acatgttcta     1980

ctgcaagcac gtggagcggc agctctgcag cgtctggatc agcaacaaaa ccgccaagca     2040

gcactcgctg cactccgccc agtggtttgc tggggctttc actctgcggc agcgaatgct     2100

caacttcgtc cagaatattc aatactacat gatgtttgaa gtgatggaac cgacctggca     2160

catcctggag aaaaacctga aatccgcctc caacattgac gacgtccttg gccaccacac     2220

aggcttcctg gacacctgcc tgaaggactg catgctcacc aaccccgagc tgctgaaggt     2280

cttctccaag ctcatgtctg tgtgcgtcat gttcaccaac tgcatgcaga aatttacaca     2340

gagcatgaaa ttagatggcg agctgggcgg gcagacgctg gagcacagca ccgtcctggg     2400

gctgcccgca ggggccgagg agcgggcccg gaaggagctc gccaggaagc acctggctga     2460

gcacgcagac actgtgcagc tggtgtccgg cttcgaggcc accatcaaca agtttgacaa     2520

gaacttctca gcccacctgc tggacctcct ggcccggctg agcatctata gcaccagtga     2580

ctgtgagcac ggcatggcca gcgtcatctc caggcttgac ttcaatggtt tctacacgga     2640

gcgcctggag cgcctgtctg cagagaggag ccagaaggcc accccccaag tgcctgtcct     2700

gcgggggccc ccggctcctg cacccagggt cgcagtcacc gcacagtgag ccctggctgt     2760

gacaggaagg aagggtgtgg ggtcagcagg gactggtgca aatgggtcca gaattttcaa     2820

atcgaatgct ctgtgttctg tctttgcagt ttaaatataa agcaggaatg attgactcag     2880

ctca                                                                  2884


<210> 310
<211> 3935
<212> DNA
<213> Homo sapiens

<400> 310
gcaacggccg ttagaggagc tgagggaggg aaccaccgct caccgcagac gtggtggctg       60

cagtcagtct tcccgagtga gggatttcgc cgcccgcttt caggcccgtt tggcttaaat      120

aactgtgatt gatggccatg caggagaaat atccaactga ggggatctct cacgtcactt      180

caccgagttc cgatgtgatt cagaagggca gttccctggg gactgaatgg cagaccccag      240

ttatctcgga gccctttcgg agccgcttca gccgctgttc aagtgtagcc gacagtgggg      300

acacagccat tggtacatca tgctcagata ttgcggagga tttttgcagc tcaagtggca      360

gtcctccttt ccagcccatc aaaagccacg taaccattcc aacagcccat gtgatgcctt      420

ctactttagg gacctctcct gccaagccaa attctacacc tgttggaccc tcttcctcta      480

aactcccttt gtcagggttg gctgaaagtg tgggaatgac aagaaatgga gacctcggtg      540

caatgaaaca ttctccaggc ctatctagag atctcatgta tttctctggt gctactggag      600

aaaatggaat tgagcagtcc tggtttccag cagtgggcca tgaaagacaa gaagaggcga      660

ggaagtttga tattcctagc atggaatcta ccctcaatca gtcggcaatg atggagacac      720

tttattcaga tcctcaccac cgagtccgct tccacaaccc aagaaccagc acaagtaagg      780

agttgtacag agtgttgcct gaggccaaga aggcaccggg cagcggggca gtgtttgagc      840

ggaatggacc acattctaat agcagtgggg tcctcccttt gggactccag cctgctcccg      900

ggctctccaa gcctctgccc tctcaggtgt ggcagccgag tcctgacact tggcatcccc      960

gagagcaatc ttgtgaactc agcacttgtc ggcagcagct ggaattgatt cgtttacaga     1020

tggagcaaat gcagcttcag aatggagcca tctgccacca tcctgctgct tttggtcctt     1080

cactgcccat cttagagcca gcacagtgga tcagcatctt gaacagtaat gaacaccttc     1140

tgaaggaaaa agagcttctc attgacaagc agaggaaaca catctctcag ctggagcaga     1200

aagtgcgaga gagcgaactg caagtccaca gtgccctctt gggccgccct gccccctttg     1260

gtgatgtctg cttgctgagg ctacaggaat tgcagcgaga aaacactttc ttacgtgcac     1320

agtttgcaca gaagacagaa gccttgagca gagaaaagat tgaccttgaa aagaaactct     1380

ctgcttctga agttgaagtc cagctcatca gagagtcgct caaagtggcg ttgcagaagc     1440

attctgagga agtgaagaaa caggaagaaa gggtcaaagg tcgtgataaa catatcaata     1500

atttgaaaaa gaaatgccag aaggaatcag agcagaaccg ggagaagcag cagcgtattg     1560

agaccttgga gcgctacctg gctgacctgc ccacactgga agaccatcag aagcagagcc     1620

agcagcttaa ggattctgag ttgaagagca cagagctgca ggagaaagtg actgagctgg     1680

agagtttgct ggaggagacc caggcaatct gcagagagaa ggagattcaa ctggaaagcc     1740

tgaggcagag agaagcagaa ttctcctccg ctggacatag cctgcaagat aaacagtctg     1800

tggaggagac cagtggagaa ggtccagaag tggaaatgga gtcctggcag aagcgatacg     1860

attcgctcca aaagattgtg gagaagcagc agcagaagat ggatcagttg cgctcacaag     1920

tacagagcct agagcaggaa gtggctcaag aagaaggaac aagccaggcc ctgagagagg     1980

aggcccagcg aagggattca gccctgcagc agctgcgcac agccgtgaag gagctttcag     2040

tgcaaaacca ggacttgatt gagaagaatc tgacactcca ggaacacctg cgccaggccc     2100

aaccagggtc tccaccttca ccagacacgg cccagctggc acttgagctg caccaggagt     2160

tggccagttg ccttcaagat ctgcaggctg tctgtagcat tgtgacccag agggcccagg     2220

gccatgaccc caatctctcc ctgctcctgg gcattcactc agcacagcac ccagagactc     2280

agctagattt gcagaagcca gatgtgatca agaggaaact agaagaggtt caacagctgc     2340

gtcgtgacat tgaggactta aggaccacca tgtcagacag atatgcccag gacatgggag     2400

aaaactgtgt cacacagtga ggaattctgg gggattcccc cagggaggag ctgggctgct     2460

gagagcctag tccagcaggt ttctgccctg acattctctt gtctgctatt cccagagagg     2520

tctcagaggg gaggggagag cctgcatctg ggggccaagg gctgattagg gaactgtgtc     2580

ctacccacac tggcatgttg gattacgttt gtcctgttaa ttcactctag acggtgagtt     2640

actaattaac ttttggcagg tacaacagat aagtcctcac aaactgttcc cagccctagg     2700

ctgacatgag agacgaacag gctgtccacc tttcttctcc atccaatggg atggatccat     2760

gttcattccc acttcacacc ttggtcctgc tgattagaga gctcatcaga ggggcctgga     2820

aaggctgagc aagtaccagt gacaatggcc atttaagaat tctcaggccc catgtgccag     2880

ccttcttggg aactgagctg gctttctggg ttttctcatg cctggtctta ctgcttcttc     2940

ctcagggctc ttgttctccc agaagcctca gggtaatgtg ttggttagca cgtaactact     3000

aggattgggg ccctagggat tatagccagg actctaatct gcctaccatg ccatttaaca     3060

agagatccca ctctccagct gccttgtgtc cctagggtcc tggccatgtg tttagtgtgc     3120

taaactttct cctttgttct caggccttcc aggtagtccc cttcctggac ttaagagtgc     3180

aaactcttct ctgtggttct agccttgggc agaattatat cccagagacc acagagcaac     3240

tgtcaagctg cttaccccct cacccagggc tacagcctgt gcccagccct ctaatttgtg     3300

cctctcttgt gttgggggtg gtgggggtta ttcctttccc tttcctgctc tggcctcctt     3360

gaaagttcag agtacccagt acaagtcagc tttaaagtac agcttttagt gtttcctggg     3420

ttgtttctct ggggctttag tgagggacct ttgccctctg gtttttcttg cctcctggtt     3480

tagggagcat ctcacacttg ttagtatctg gttgttgggc cagccgtgcc tcctctagat     3540

ctggagccag gccaggcagg ggccacgtgt gggccagtca gccactacaa gatttttgct     3600

aagctttggg ctgttggcag catcttggac ctcatgcctg ggcctgaatg aggctctttc     3660

ttaagtgttt ttacaagttt gtgttttatt tatggagtga cttatccctt ccattcagag     3720

cagccccacc cagccagccc ttcagcctct gggctcctgc tgcttaaagg cagagccgcc     3780

tggttggtct ccaccctgtg cattgggagc ccagccacca tgctgacggg tatttttcct     3840

cataaagttt ataaccagtt atttatatga atctttgtta tgtccatttg tttgtattgc     3900

gtattttgat tataaaataa agtatcttaa cagac                                3935


<210> 311
<211> 3453
<212> DNA
<213> Homo sapiens

<400> 311
tccgcggcgg ggatgctgag gagcgctggg tccgggagca gccctggccc ctgcggactt       60

ccgaggccgt gaaaacccct gcgctgcggc ccttcccagg cccccgaggc cgttcgccgt      120

tcccgaagcc cgactggggg aagagtccag caccaaagcg gccgttctcg gattccggag      180

cgttctggag ccccgagaga cgccccgggg ttctagaagc tccccggcgg cgcccagtcc      240

cggcttcatt cgggcgtccc tccgaaaccc actcgggtgc acgggtcgtc ggcgagccgc      300

gaccgggtcc tggcgcgcac catgatcgtg gcggactccg agtgccgcgc agagctcaag      360

gactacctgc ggttcgcccc gggcggcgtc ggcgactcgg gccccggaga ggagcagagg      420

gagagccggg ctcggcgagg ccctcgaggg cccagcgcct tcatccccgt ggaggaggtc      480

cttcgggagg gggctgagag cctcgagcag cacctggggc tggaggcact gatgtcctct      540

gggcgagtag acaacctggc agtggtgatg ggcctgcacc ctgactactt taccagcttc      600

tggcgcctgc actacctgct gctgcacacg gatggtccct tggccagctc ctggcgccac      660

tacattgcca tcatggctgc cgcccgccat cagtgttctt acctggtagg ctcccacatg      720

gccgagtttc tgcagactgg tggtgaccct gagtggctgc tgggcctcca ccgggccccc      780

gagaagctgc gcaaactcag cgagatcaac aagttgctgg cgcatcggcc atggctcatc      840

accaaggaac acatccaggc cttgctgaag accggcgagc acacttggtc cctggccgag      900

ctcattcagg ctctggtcct gctcacccac tgccactcgc tctcctcctt cgtgtttggc      960

tgtggcatcc tccctgaggg ggatgcagat ggcagccctg ccccccaggc acctacaccc     1020

cctagtgaac agagcagccc cccaagcagg gacccgttga acaactctgg gggctttgag     1080

tctgcccgcg acgtggaggc gctgatggag cgcatgcagc agctgcagga gagcctgctg     1140

cgggatgagg ggacgtccca ggaggagatg gagagccgct ttgagctgga gaagtcagag     1200

agcctgctgg tgaccccctc agctgacatc ctggagccct ctccacaccc agacatgctg     1260

tgctttgtgg aagaccctac tttcggatat gaggacttca ctcggagagg ggctcaggca     1320

ccccctacct tccgggccca ggattatacc tgggaagacc atggctactc gctgatccag     1380

cggctttacc ctgagggtgg gcagctgctg gatgagaagt tccaggcagc ctatagcctc     1440

acctacaata ccatcgccat gcacagtggt gtggacacct ccgtgctccg cagggccatc     1500

tggaactata tccactgcgt ctttggcatc agatatgatg actatgatta tggggaggtg     1560

aaccagctcc tggagcggaa cctcaaggtc tatatcaaga cagtggcctg ctacccagag     1620

aagaccaccc gaagaatgta caacctcttc tggaggcact tccgccactc agagaaggtc     1680

cacgtgaact tgctgctcct ggaggcgcgc atgcaagccg ctctgctgta cgccctccgt     1740

gccatcaccc gctacatgac ctgactcctg agcaggacct gggcccggtt cagctcccca     1800

caaggacttc tctgtctgga gacagcccca gacccttttg tgtcccatgc ccaccctccc     1860

cacgctgcag tgggcttgtg tgtgatgtgc agtcccgaag ccacaccctc ccttttcctc     1920

actggaatgg acagttcatt gcactgactc tgggatctca gccctgctcc tgggagctgg     1980

aagagcactt ggagatccta agggaccaca cccttcctcc ttcccctgcc cacagaggca     2040

gagggcacag gaaagaagcc gggccaagct cggaattaat gtgccacaag tgttgtggcc     2100

ttcctgaact gggaagtccc tggctggccc ccgggggaga ggggcaaatg cctccgggac     2160

tgacactcca ggcagctttg ccttctctcc cctgtcattt ccagatttca ttacctccta     2220

cttgccattc acccatcaat gtgaaagtca gggtcacagc tggtctgtgt gtccagttcc     2280

ctaaaagcct gttctgttgg gcagcctgag gctgttgccc gaatcctagt tcagtttttt     2340

gacttccttt gccctttttc ccttttctcc atgcttaatg gtgtgaggcg tcaggagaga     2400

ggccaagtac ataaaaaaaa aaaaagcaga ttatctctag agagtttgag cctttgctgg     2460

tcacattgcc ttctgaagag gagggagtat tagattataa atcctcttta ttttggtcct     2520

ttatgcttga ggttccaacc tggagccaca gtgtgtgaga ggaggaggag agggagaatt     2580

ctgttctccc agagctgcac ctgcctcgca gaggccagca ccccactctc ctgcctccag     2640

tggccctgcc gcagatgtct cccaaaaagt tgagcctttc tagatggctt aggtggcacc     2700

atggctcagc aggaggggcg ggaggcacca gggttcttgt ttggaccctg cccctgggcc     2760

atggccaggt gaccatggct acattgccaa acctctgact gccacagctg cagactgaga     2820

gggtgggtct gagtccccac aatgtctgaa gctgcccctg ggattctcag gccaacctgc     2880

caacagcaag cggattttct tgcaagatca gggaccccat ttctgcagcc agtgtctcct     2940

gggtgccttc tgaggactcc cacccccatc ccagtatctc atctgtcccc tctcctgggg     3000

cttaagtggg ttgcttccag gcagaagcag ccaaggaccg attccaggca ctttctgtag     3060

caaatgactg tgaattacga cttctcttgc ccttcttcta gcagtctgtg cctcctctct     3120

gaccagtttg gagggcactg aagaaaggca agggccgtgc tgctgctggg cggggcagga     3180

gaggagcctg gccagtgtgc cacattaaat acccgtgcag gcgcggagaa gcaaccggca     3240

cccccttccg gcctgaaagc cctccctgca agaaggtgtg caggagagaa gaggccccgg     3300

catggggatc tgggttctag agggcatgtg atgactgtaa atgttcactg ggtgggtagg     3360

gagtggtatc cagtgttcaa gtgcagaaat ctttggcttt gctaccagtt ccatatgatg     3420

agaaataaac gttcgctgag gttttgtttc ata                                  3453


<210> 312
<211> 1962
<212> DNA
<213> Homo sapiens

<400> 312
tccggcggcg ccgggcgaga agcgcgactg gagtctgggg ctgcggcttc ccagaggcgc       60

gagtcgcttt tccaggagcc gaggcccaaa cggggccggg cctgaagggt cccccgccag      120

cccgcggccg cgccatcaat cgccgccgcc tcgtcccgct tctcggctga ggcgccgcgc      180

ggccaggcag cgggtccagg cctcagccgc gcgcccaggg gcctccgggg ccctcccggg      240

tcagcatgcc cggggtgaaa ctgaccaccc aggcctactg caagatggtg ctgcacggcg      300

ccaagtaccc gcactgcgcc gtcaacgggc tcctggtggc cgagaagcag aagccgcgta      360

aggagcacct ccccctgggc ggccccggcg cccaccacac cctcttcgtg gactgcatcc      420

ccctcttcca cggcaccctg gccctcgccc ccatgctgga ggtggctctc accctgattg      480

attcatggtg caaagatcat agctacgtga ttgctggtta ttatcaagct aatgagcgag      540

taaaggatgc cagtccaaac caggttgcag agaaggtggc ctccagaatc gccgagggct      600

tcagcgacac tgcgctcatc atggtagaca acaccaagtt tacgatggac tgcgtagcgc      660

ctacgatcca cgtgtacgag caccatgaga acagatggcg gtgcagagac ccacaccatg      720

actactgtga agactggcca gaggcacaga ggatctcagc ctcgctcctg gacagccggt      780

cctacgagac gctcgtggat ttcgataacc acctggatga cattcggaat gactggacaa      840

acccagagat caataaagct gtcctacact tgtgctaggc aggcaccgct gtgactgggc      900

tccgggcctt tccactacgt tgaagaagaa aacctatttt taaatgtaaa taaaatatct      960

tgtagcctgt gtggaaagct gaccgtttta agaagtggca tgtgccttga aagggggcag     1020

aatgttcagt cggtcgtgtt tttaacacag agtctctaga agaggtgcag acatcccgtc     1080

tgactgtccc tgtggactct ctcagttgta tgttgctata atcctccaaa tcaaagctct     1140

ttctgcttgt gcaagattgt tcctattaaa cagttttaac taacctttta taatctggag     1200

agaatacttt ttaaggcttt tgaactatct ttttttaaaa aaaaaaaaaa aagcccacat     1260

cttatactcc aatgagtgtg tttgtgagtt tttatcctgt ttgaattttg atgtcgtcca     1320

ggcgtcctgg gatcagggta gacacgtgga gtgctggtgc tgagctgttt gagaagctct     1380

gtgtgggtgt ttctgtggtc aggtaggctg ggctgtgaac agcactgctc cacatggtgt     1440

cggctcacag agccaccgca actctgccca gcgggagtga caccactgat gccacagaag     1500

cctttatcgt taggggcaaa agcagacatc tctggtagca ggagctcagt gtggtgctct     1560

tcagccacgc agaaagctca cgtgcctgca gggccaggaa agggaaatga tcgtttcttt     1620

tgtattagga aaaacaagac ttagacttcc cgagttgtgc agagtgacgt ctgtactttt     1680

tatacttaga acatttggtc aagttttgta accaaacctt agggaattga gagggaaact     1740

ttatggtacg tttacctttt ttccttttta tatgaattat tttgtacaaa gttcagagag     1800

cggtaccttt cctactgtct tttctttgac tccatggagg aatttgtaac gatcggtgtg     1860

acctgaaagg gtttgtgata cagcggtcac tattttctct taacacatag gaaaaaagtt     1920

cagacatcgc tacaataaat gtgctttatt tgatccacca aa                        1962


<210> 313
<211> 2329
<212> DNA
<213> Homo sapiens

<400> 313
gtccttccca agaccacacc caggtccagt cattccctag gacttggcag agagctgtac       60

tcacagccaa gatcacagca aaatcagcaa agggaaaagg catgcagagt gaagtccaga      120

ggcaaccaga cagaagcatc cagaatcctc tcacagtggg gtcacacacc ccatgcttaa      180

ctcccccaac aatgagttgt aacaacagtc aggtgtggtg gtgtgtgcct gtagtcccag      240

ctacttggga gcctgaggca ggaggatcac ttgagtccag cagttcaaga ctgcagtgag      300

ctatgatcat accactgcac tccagcctga gtgacagagt gaaactctgt ctctaaaata      360

gggctcacct gcttgaggaa acaggaactg cctcggggca gccagccccg ccccattgac      420

gtgcagacct tgaatcgaaa cccaggctcc tgcaggcact ggcacagcta cagcgagggc      480

ctcggccatc caagggtctc ccaggtgacc ttccctccac cccaggaagc tatgacagag      540

gccgggaagc tgcccctacc gctaccccca cggctggact ggtttgtgca cacccagatg      600

ggccagctgg cccaagacgg ggtccccgag tggttccatg gtgcaatctc aagagaggat      660

gctgagaact tgctggagtc acagccactg ggatcctttc tcatcagggt cagtcacagc      720

catgtgggct acacactctc ctacaaagcc caaagcagct gctgccattt catggtgaag      780

ctcttggatg atgggacttt catgatcccc ggggagaagg tggcccacac ctcgctggac      840

gccctggtca ccttccacca gcagaagcca attgagccgc gcagggagct gctgacacag      900

ccctgcaggc agaaggatcc cgcaaacgtg gattacgagg atctcttcct ctactccaac      960

gcagtggccg aggaagctgc ctgcccggtg tctgcccctg aggaggcctc cccaaagcca     1020

gtcctgtgtc accaatcaaa ggaaaggaag ccgtcagcag agatgaacag aataaccacc     1080

aaggaagcca cttcctcctg ccccccaaaa tcccctcttg gagagacccg ccagaaactc     1140

tggaggagcc tcaaaatgct ccccgagaga ggccagaggg tccggcagca gctaaaaagc     1200

cacctcgcca ctgtgaactt gtcgtcactc ttggatgtcc ggagatccac ggtgatctca     1260

ggccctggga ccggaaaagg cagccaagat cactcagggg atcccacctc gggggacaga     1320

ggctacacgg atccctgtgt ggccacatct ctcaaaagcc cctcacagcc ccaggcacca     1380

aaagacagaa aggtccccac caggaaggcc gagaggtcgg tcagctgcat tgaggtgacc     1440

ccaggggaca ggagttggca ccaaatggta gtgagagccc tatcctccca ggagtccaag     1500

ccagagcacc agggcttggc agagcctgag aacgaccagc tcccggagga gtaccaacaa     1560

ccgccaccct ttgcccctgg gtactgctag agaacaggtc caccctggct ctgggactcg     1620

ctgccagggg ctgccacact cctgaatgcc ttaacatttc ttccatggcc ccacaccatg     1680

gcatccgggg gtcttcggga acccgggaaa tggaataaag atgtttttgg ggtctgttcc     1740

tgcactcacc catggggtga gctggttatt ttagcaacaa tcatcagagt gacgctgatg     1800

gtttggggca ccagctatac atcagcccca gtgccagacc ttctattcat tattttacgc     1860

ctcagagcaa ggccctcagg gagggtcatc ctccatgttt tgaagaagag actgaggttc     1920

agagaggata agaggcgtga ccaaggccac agagctatgg gtgtcagcac caggatttga     1980

agccaggtga atccgagccc ttttcccata tcatctgttt gttctgttgt ctaaaagcac     2040

actgcaagcc gggctcagtg gctcatgcct gtagtcccag cactctgtgg ggccgaggca     2100

ggcagatcgc ttgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccgtc     2160

tatactaaaa aattcaaaaa ttacccggac gtggtggcgc atgcctgtaa tcccagctac     2220

ttgggagcct gaggcgggag aattgcttga acccgggagg cagaggttgc agtgagccga     2280

gatcgcatca ctgcagtcca gcctggatga cagagtgaga ctccatctc                 2329


<210> 314
<211> 960
<212> DNA
<213> Homo sapiens

<400> 314
tgacaccatg acccactgtt gttccccttg ctgtcagcct acgtgctgca ggaccacctg       60

ctggaagccc accactgtga ccacctgcag cagcacaccc tgctgccagc cctcctgctg      120

tgtgtccagc tgctgccagc cttgctgccg cccaacttgc tgtcaaaaca cctgctgcca      180

gcccatctgt gtgaccagct gctgccagcc ttcctgctgc agcacaccct gctgtcagcc      240

cacctgctgt ggccaaacca gctgtgggtc cagctgtggt cagagcagct cctgtgcacc      300

tgtgtactgc agaagaacct gctaccaccc cacgactgtc tgcctgcctg gttgcctaaa      360

ccagagctgt ggctccaact gctgccagcc ctgctgccgc ccagcctgct gtgagaccac      420

ctgctgcagg accacttgct tccagcccac ctgtgtgtcc agctgctgcc agccttcttg      480

ctgctgatca cgttccaaga gaaccaccat cctcacacaa caaatttctg ctcaactgac      540

tcatcttttg ggggactaat ttaatttgct gctgacagcc accatgctct cacccaaatt      600

tttatgaatt ctctacatgt ttaaaatctt ggaaatctgc ttgagggagg gcagaatact      660

tcatcctgat tctctttttc cttacacctt gtggatcatg tgccagcttc atctgttctc      720

aagtttgagt catggtctca gctttgactc taaagtcaag agcttcattc cctgcttcta      780

aggaatttag gtttctgcaa ctgatcgatg atctttgcaa tctttttttt gttttcaata      840

tcctcctcat cgttcttgta tccttctttc ttcttttcat gataaatttg tgttgtgtcc      900

ctggtagcag aaatccttac ctatatgttt ctgaataaat tctgaaccat cctcatctca      960


<210> 315
<211> 1843
<212> DNA
<213> Homo sapiens

<400> 315
agctgggacc ggagggtgag cccggcagag gcagagacac acgcggagag gaggagaggc       60

tgagggaggg aggtggagaa ggacgggaga ggcagagaga ggagacacgc agagacactc      120

aggaggggag agacaccgag acgcagagac actcaggagg ggagagacac cgagacgcag      180

agacacccag gccggggagc gcgagggagc gaggcacaga cctggctcag cgagcgcggg      240

gggcgagccc cgagtcccga gagcctgggg gcgcgcccag cccgggcgcc gaccctcctc      300

ccgctcccgc gccctcccct cggcgggcac ggtattttta tccgtgcgcg aacagccctc      360

ctcctcctct cgccgcacag cccgccgcct gcgcggggga gcccagcaca gaccgccgcc      420

gggaccccga gtcgcgcacc ccagccccac cgcccacccc gcgcgccatg gaccccaagg      480

accgcaagaa gatccagttc tcggtgcccg cgccccctag ccagctcgac ccccgccagg      540

tggagatgat ccggcgcagg agaccaacgc ctgccatgct gttccggctc tcagagcact      600

cctcaccaga ggaggaagcc tccccccacc agagagcctc aggagagggg caccatctca      660

agtcgaagag acccaacccc tgtgcctaca caccaccttc gctgaaagct gtgcagcgca      720

ttgctgagtc tcacctgcag tctatcagca atttgaatga gaaccaggcc tcagaggagg      780

aggatgagct gggggagctt cgggagctgg gttatccaag agaggaagat gaggaggaag      840

aggaggatga tgaagaagag gaagaagaag aggacagcca ggctgaagtc ctgaaggtca      900

tcaggcagtc tgctgggcaa aagacaacct gtggccaggg tctggaaggg ccctgggagc      960

gcccaccccc tctggatgag tccgagagag atggaggctc tgaggaccaa gtggaagacc     1020

cagcactaag tgagcctggg gaggaacctc agcgcccttc cccctctgag cctggcacat     1080

aggcacccag cctgcatctc ccaggaggaa gtggagggga catcgctgtt ccccagaaac     1140

ccactctatc ctcaccctgt tttgtgctct tcccctcgcc tgctagggct gcggcttctg     1200

acttctagaa gactaaggct ggtctgtgtt tgcttgtttg cccacctttg gctgataccc     1260

agagaacctg ggcacttgct gcctgatgcc cacccctgcc agtcattcct ccattcaccc     1320

agcgggaggt gggatgtgag acagcccaca ttggaaaatc cagaaaaccg ggaacaggga     1380

tttgcccttc acaattctac tccccagatc ctctcccctg gacacaggag acccacaggg     1440

caggacccta agatctgggg aaaggaggtc ctgagaacct tgaggtaccc ttagatcctt     1500

ttctacccac tttcctatgg aggattccaa gtcaccactt ctctcaccgg cttctaccag     1560

ggtccaggac taaggcgttt ttctccatag cctcaacatt ttgggaatct tcccttaatc     1620

acccttgctc ctcctgggtg cctggaagat ggactggcag agacctcttt gttgcgtttt     1680

gtgctttgat gccaggaatg ccgcctagtt tatgtccccg gtggggcaca cagcgggggg     1740

cgccaggttt tccttgtccc ccagctgctc tgcccctttc cccttcttcc ctgactccag     1800

gcctgaaccc ctcccgtgct gtaataaatc tttgtaaata act                       1843


<210> 316
<211> 3530
<212> DNA
<213> Homo sapiens

<400> 316
ctctcgggcc agcctcagcc gccgcgcctc agtccgccgt ccgccctccg cgcccgcgcc       60

gctagcatga ccgacgcgct gttgcccgcg gccccccagc cgctggagaa ggagaacgac      120

ggctactttc ggaagggctg taatcccctt gcacaaaccg gccggagtaa attgcagaat      180

caaagagctg ctttgaatca gcagatcctg aaagccgtgc ggatgaggac cggagcggaa      240

aaccttctga aagtggccac aaactcaaag gtgcgggagc aagtgcggct ggagctgagc      300

ttcgtcaact cagacctgca gatgctcaag gaagagctgg aggggctgaa catctcggtg      360

ggcgtctatc agaacacaga ggaggcattt acgattcccc tgattcctct tggcctgaag      420

gaaacgaaag acgtcgactt tgcagtcgtc ctcaaggatt ttatcctgga acattacagt      480

gaagatggct atttatatga agatgaaatt gcagatctta tggatctgag acaagcttgt      540

cggacgccta gccgggatga ggccggggtg gaactgctga tgacatactt catccagctg      600

ggctttgtcg agagtcgatt cttcccgccc acacggcaga tgggactcct gttcacctgg      660

tatgactctc tcaccggggt tccggtcagc cagcagaacc tgctgctgga gaaggccagt      720

gtcctgttca acactggggc cctctacacc cagattggga cccggtgtga tcggcagacg      780

caggctgggc tggagagtgc catagatgcc tttcagagag ccgcaggggt tttaaattac      840

ctgaaagaca catttaccca tactccaagt tacgacatga gccctgccat gctcagcgtg      900

ctcgtcaaaa tgatgcttgc acaagcccaa gaaagcgtgt ttgagaaaat cagccttcct      960

gggatccgga atgaattctt catgctggtg aaggtggctc aggaggctgc taaggtggga     1020

gaggtctacc aacagctaca cgcagccatg agccaggcgc cggtgaaaga gaacatcccc     1080

tactcctggg ccagcttagc ctgcgtgaag gcccaccact acgcggccct ggcccactac     1140

ttcactgcca tcctcctcat cgaccaccag gtgaagccag gcacggatct ggaccaccag     1200

gagaagtgcc tgtcccagct ctacgaccac atgccagagg ggctgacacc cttggccaca     1260

ctgaagaatg atcagcagcg ccgacagctg gggaagtccc acttgcgcag agccatggct     1320

catcacgagg agtcggtgcg ggaggccagc ctctgcaaga agctgcggag cattgaggtg     1380

ctacagaagg tgctgtgtgc cgcacaggaa cgctcccggc tcacgtacgc ccagcaccag     1440

gaggaggatg acctgctgaa cctgatcgac gcccccagtg ttgttgctaa aactgagcaa     1500

gaggttgaca ttatattgcc ccagttctcc aagctgacag tcacggactt cttccagaag     1560

ctgggcccct tatctgtgtt ttcggctaac aagcggtgga cgcctcctcg aagcatccgc     1620

ttcactgcag aagaagggga cttggggttc accttgagag ggaacgcccc cgttcaggtt     1680

cacttcctgg atccttactg ctctgcctcg gtggcaggag cccgggaagg agattatatt     1740

gtctccattc agcttgtgga ttgtaagtgg ctgacgctga gtgaggttat gaagctgctg     1800

aagagctttg gcgaggacga gatcgagatg aaagtcgtga gcctcctgga ctccacatca     1860

tccatgcata ataagagtgc cacatactcc gtgggaatgc agaaaacgta ctccatgatc     1920

tgcttagcca ttgatgatga cgacaaaact gataaaacca agaaaatctc caagaagctt     1980

tccttcctga gttggggcac caacaagaac agacagaagt cagccagcac cttgtgcctc     2040

ccatcggtcg gggctgcacg gcctcaggtc aagaagaagc tgccctcccc tttcagcctt     2100

ctcaactcag acagttcttg gtactaatgt gaggaaacaa acatgttcag gccctgaaca     2160

tttccggtgc tgactcggcc ttaaacgttt gtgccataat ggaaaatatc tatctatctg     2220

ttctcaaatc ctgtttttct catagtgtaa actcacattt gatgtgtttt tatgaaggaa     2280

agtaaccaag aaacctctag gaattagtga aaaaagaact tttttgaggt gtgttactat     2340

actgctgtaa gttatttatt atataaagta ttgtaaatag aatagtgttg aagatatgaa     2400

atatggctat ttttaatggt gacaattatg acttttagtc actattaaat tggggttacc     2460

tatatcagta caatttgtag ttgtttccag gtttggctaa taatcattcc ttaacctaga     2520

attcagatga tcctggaatt aaggcaggtc agaggactgt aatgatagaa ttaaattagt     2580

gtcactaaaa actgtcccaa agtgctgctt cctaatagga attcattaac ctaaaacaag     2640

atgttactat tatatcgata gactatgaat gctatttcta gaaaaagtct agtgccaaat     2700

ttgtcttatt aaataaaaac aatgtaggag cagcttttct tctagtttga tgtcatttaa     2760

gaattactaa cacagtggca gtgttagatg aagatgctgt ctacaaggta gataatatac     2820

tgtttgatac tcaaaacatt tttcattttg tttaaagtag aagttacata attctatatt     2880

ttaagtcttg ggtaaaaaag tagttttaca ttttataaag taaagatgta aatgattcag     2940

gtttaaagct ctatttgact tccttttttt gtttgagata gcgtcttgct gtgttgccca     3000

ggctggagtg cagtggtgtg atctcagctc agtgcaacct ccgccccctg ggatcaagcg     3060

attctcctac ctcagcctcc caaatagctg ggactacaag gtgccctcca gcatgcctgg     3120

ctgatttttg tatttttagt tgaggtgagg tttcaccatg ttggccaggc gggtttcgaa     3180

atcctgacct caaatgatcc acccacctca gcctcccaaa gtgctgggat tacaggcatg     3240

agccaccaca accgtcccac tattttactt tttaaaatga cattcctact gattgatttt     3300

tatcttgcta taagttcgat gacaccgtga atctaataag gttcactgtt gacacagtac     3360

aagttacata gctaaaatac atagcattga agactaattt taaggattga caagagttta     3420

ttttctattg tgcaatatct taaaggaagc aaccaccttt gggaaagtgt atctgctgct     3480

cctagggcca tgcttgtata catatttaaa taaacatatt catttacccg                3530


<210> 317
<211> 1815
<212> DNA
<213> Homo sapiens

<400> 317
gccccggccc cgccccgcga gcgccgagac ttgttggccg cggagactgc gaccctcttc       60

tctcagtctg ccttactacc atgccgctct acgagggcct ggggagcggc ggggagaaga      120

cggcggtcgt gatcgacctg ggagaggcct ttaccaagtg tggatttgct ggagaaactg      180

gtccaagatg tataattcct agtgtgataa aaagagctgg gatgcctaag cctgtcagag      240

ttgttcagta taatatcaat acagaagaat tatattccta cctaaaggaa ttcatccaca      300

tactatattt caggcatcta ttggtgaatc ccagagaccg ccgagttgtg attatcgaat      360

cggtattatg tccttctcac ttcagagaga cactcactcg tgttcttttc aaatattttg      420

aggttccatc tgtcttgctt gctccaagtc atctaatggc tcttctgacg cttggaatta      480

attctgccat ggtcctagat tgtggatata gggaaagcct ggtgttaccc atatatgaag      540

gaatcccagt tctaaattgt tggggagcac tacccctagg aggaaaagct cttcacaaag      600

agttggaaac tcaactattg gaacaatgta ctgttgacac aagtgttgct aaagaacaga      660

gccttccctc agtgatgggt tcagttccgg aaggtgtctt agaggacatt aaagcgcgta      720

cttgctttgt aagtgatctg aagcgaggac taaaaatcca agcagcaaaa tttaatattg      780

atgggaataa tgagcgtccc tccccacccc caaatgttga ctatccatta gatggagaga      840

agattttaca tatccttgga tcaatcagag attcagttgt ggaaattctt tttgaacaag      900

ataatgaaga gcaatcagtt gccactttaa tattggattc ccttatacag tgtccgatag      960

acaccaggaa gcaactagca gagaatttgg tagtcatagg tggcacttct atgttgccag     1020

gatttctcca cagattgctt gcagaaataa ggtatttggt agaaaaacca aaatataaaa     1080

aagcacttgg cactaagaca tttcgaattc atactccacc tgcaaaagct aattgtgtgg     1140

cctggttggg aggggctatt tttggagcat tacaagatat acttgggagc cgttctgttt     1200

caaaggaata ttataatcag acgggccgta tacctgattg gtgttctctc aataacccac     1260

ctttggaaat gatgtttgat gtcgggaaaa ctcaaccacc tctgatgaag agagcatttt     1320

ccactgagaa atagaagttt gattaaaaat caaccttgct tcatatcaaa tatttaacca     1380

attataagca aattgtacaa agtatgtagg atgttttgtt atagaggact atagtggaag     1440

tgaaagcatt ctgtgtttac tctttgcatt aatatataat tcttttgact ttgtttctct     1500

tgtgtagtgg taaaatggta gctggtgctt attgagattt gctgtattta tatcaataaa     1560

gtatagtaaa gcagtttgat tttggaagtt tgttatgtgg cttttttttt tttttttttt     1620

ttgagacgga gtctcgctct gtcacttagg ctggagtgca gtggcacaat ctctactcat     1680

tgcaagctcc gcctcccggg tttacgccat tctgtctcag cctcctgagt agctgggact     1740

ataggcatac gccaccccgc ccggctaatt ttttgtatat ttagtagaga cggggtttca     1800

ccatgttagc cagga                                                      1815


<210> 318
<211> 3014
<212> DNA
<213> Homo sapiens

<400> 318
ccacctcctg ccctgctggg gtccagccat gtcccagcct gcgggaggca ggaggaagcc       60

caggacccta gggccgcctg tgtgcagtat ccggcctttc aagtcgagtg agcagtacct      120

ggaggccatg aaggaagacc tggctgagtg gcttcgcgac ctctatgggc tggacatcga      180

cgcagccaac ttcctgcagg tgctggaaac gggcctggtg ctgtgccaac acgccaacgt      240

tgtcactgac gctgccctgg ccttcctggc tgaggcacct gcccaagccc agaagattcc      300

catgccccgg gtcggggtct cctgcaatgg ggccgcccag ccaggtacct tccaggccag      360

ggacaatgtc tctaacttca tccagtggtg tcgaaaggag atgggcatcc aagaggtgct      420

gatgttcgag acggaggact tggtgctgcg caagaacgtg aagaacgtgg tgctgtgttt      480

gctggagctg ggccgccggg cgtggcgctt tggtgttgcg gcgcccacac tcgtgcagct      540

ggaggaggag atcgaggagg aggtgcggcg ggagctggcc ctgcccccgc ccgacccctc      600

gccgccagcg ccccccaggc gccagccctg ccacttccgc aacctggacc agatggtgca      660

gagccttgtg agccactgca cgtgcccagt gcagttctcc atggtcaaag tgtctgaggg      720

gaagtaccgt gtgggtgact ccaacaccct catcttcatc cggatcctcc ggaaccatgt      780

gatggtacgt gtagggggcg gctgggacac actgggccat tacctggaca aacatgaccc      840

ctgccgctgc acatccctct cacacaagcc aggcagcttc ctgaagcccc cggccccacc      900

agtgcagcat gaagtaaggg tacaggatgg accctcacag acccagccta caatgaccat      960

cagccgctca cagagcccac caccccctgt ggactggaag acatatacct cttcagaccg     1020

aaggctgagg ccccccaccc catcctcccc cagaccccgc agggaacggg gagcagggac     1080

gggggcctcc agagagatgg caccattcct gaggtgccag gagaggtctc tcatcccatc     1140

ttggaggcag ccgacagctg gggacagccc acccagcccc cagtcctcat ctacccaaaa     1200

aggccgagac ccacagtgta cctcgtcagg aaagagggag gagagatacc cccctgaact     1260

ccccagggga aggattccca catcttgggt tcatgaagaa acagacagct ggggaaccga     1320

cgccgggaac cccaccccac aaagactccg agccattgag gccaccacca aagggatatc     1380

agcaagagga ccatctcccc tgcctcgttc ctttggccca gccgagtgcc tgggcctcag     1440

gctgccactc cgggatgagg ccaagggtgc gttcttccag ttcagggagc cagagtctgt     1500

ccgttctcca acccctgtcc aaggcctaac caagatcccc atccggctgc cccctgctcg     1560

ccccccaaca ccaggaagga gctttcctgg tgctacaagt ggaagtccca ggacagaact     1620

tgggagagac cccatcccac taagggccgt cactgtggac ctggctgggt ccacgcatgg     1680

ggactgctct gtggaagtga ggcaggagga ccagcagctg gacatccagg tcatggcaga     1740

ggccagagag tcctgggacc tgggcctaca ggagcaggag gggcggtaca cacctctgcc     1800

cttgggcggg aacaaggagc aagccatcta ctgtagcctt gaagaggaga ttttgggcaa     1860

catgaagctg ctagaagtca ggagtgcctg tccgcagggc acaaggtctg gggtcatccc     1920

tcgcagtggg gtctacatcc ccaggctggc tgggcagtgg cctgagcctg ggggtcctta     1980

tgacaaagcc atccaagaac tggctcaggg gtccccatcc ctccttaaag tggacctgga     2040

agcctggaag gcagccccga ctggctcccc taagccagct gttaccccag gaccgggaag     2100

cctcaaaggg aagttgggag ccagacagag tgggcccagg acaaaggcaa gcctgagtgc     2160

caagggcacc cacatgagga aggtcccacc tcagggaggg caggactgct cggcttctac     2220

tgtgtctgcc agcccggagg cccccacacc ttcgcccttg gaccccaact ctgacaaagc     2280

caaggcatgt ctgagcaagg gcaggagaac tctccggaag cccaagaggg tcccgtccat     2340

ctacaagctg aagctgagac ccaggattcg gccccggaga gaccacaggc ctgagaagca     2400

gccttcacga atccccaggc cactggccta tgtcttcctg ggtccagcca ggcagccccc     2460

caaggacagg ctgttgagag ctgtgctggg cagcaaggga ggggaggcat cccgggtgga     2520

tggagcttca gtaggtgagg aggaggagga aggaaaggag gagaaagagc cagccgctcc     2580

attggagagc agcccccaac ctccagaggg cctgcaacct cactggctta atcaagctcc     2640

acttccacct gaggaggagt cctgggtctg aggcacatga gcgtgttggg taggagggaa     2700

gcaaaaagga tggccatgta tacactggat tcacagctgc gggaacagaa gggatgttcc     2760

ctcacctcca cacagggcct tgggcaggag tgggtcagaa gacaaatata gactccatct     2820

gctcatctga gcaaaggggc aacccactgc tctcactcca actccagagg taggccaggg     2880

gcagtaggac catcctgtat ctcattactc tcccctagaa cggctcacca cactcctggc     2940

ctctggcccc tggccatgcc cacctgtttc cataactccc ataagttatt aaatgcatgt     3000

gattctgccc ttga                                                       3014


<210> 319
<211> 14862
<212> DNA
<213> Homo sapiens

<400> 319
aacggttcta acagctgggt gcgggtggag ctgcgggcga tcgccagctc gagtgcagat       60

tccttgctgt gaccgaggtt cagagtgagc tctgtcggtg tgtcagtttg cctcttcagg      120

cactcttcaa tgaaacctca tcagcagatc gggctctctt cccttgcctt gcctcctaac      180

ccccctaggc caggtgaggg ggacagggta ctgggaggta agaaggaact cttctgcaag      240

gagggctctc acgtctgtct taggcctgct ccttaccaga gtctttgggg aagcagtagg      300

gagggcctga gggtctcagg aaaggctctc tgctggtctg gctctgctct gtagctccat      360

ctatttccct gtcccaggtc ctttcttcct cctaacccca ttgactctga ccatcccctg      420

cccagagcct gaggtccctt ctctggcccc tctgctgggc tggcccatgc aggtgaggcc      480

ccgcatctgg catcctggaa ctggcagttg gagcctgagc tatgggcaag gtcacttcga      540

cagcagttga atgcccagct cctcatggtc ccggaggaga ggagggtagg tttgtcttct      600

gatgagacat catctgattc ccttaagtct tggcactcca tatgtgtctt ggacagcaaa      660

gaacagccct tggcctgcca gcagaaacag aggcagttcg tgaagccagt gactgagtca      720

gagcagccca cagtgctgga actcctgcta gctgagctcc gaactctgtt ctcagctgtg      780

ttgcaggaca gtagccctgc agcttggcgc tatcttcatg cagtactggg tctactgcct      840

ccatatcgtg agttgctagt tggccacctt gatttgctgc ccttcctgga gcagctgtac      900

tgctgggcac cctgggtcca aacccacctc catctggacc tgctaggtgc cattgtccag      960

gcctttcctc cagacagctc tttgttagac agtgcttccc atgctgactg ctgtccccag     1020

aagcggaggc tccatcacag gcccccatgc ccagcttgcc cttttgtgca ggcccagtgg     1080

agcaggcagc aagtaaagga ggagctggcc acctggctgc gaccattgac actgcctgag     1140

ctacagcgct gcctgggcat tgttggtgct caggtggccc tagaagaggc tgtgtggctg     1200

gatggactta gtctccttcc cttggcactg gcagcggaca tccctgtacg gtatgaaagc     1260

agtgacactg acaatgcaga ggtggagcct gttggaagaa aagagaccag gtctcagctt     1320

gactatgaag ttcccaggga aaaggccttc caaaagagca gcaccggctt ttcacctgag     1380

acttccttcc tggatagcca ggtgatgact gctctgaaga tggagagata cctgaagaag     1440

atccacttcc tctatctcaa tgtggctccc agccggtact ttaggcctta cagcctgatg     1500

gtggtgccac ccgacaaggt gaatcccgag cactacatct tctctccctt tgggatcttg     1560

catgtacatc ctgtggaagg tagcgagacg atgacactgg gtacctggca ccatcactgt     1620

gttctctggc agcagctcca gttcattcca ttctttaagt attgcctctt acgcaagtcc     1680

tttacctgtt ggaagaagaa tgtgagatta caggggctgc atcgactcca gaaattccta     1740

gagaatcatc tgctcttggc tgtgccccac tttggagctg ggctactcca tattagcagg     1800

cttctgcagg agctacactc tgtgtcctgg ctaccccagg aactggatcg gtgctatgag     1860

ctgctggacc tgcagacggc tctagccgag gagaagcata aggctctacg gctgctccat     1920

cgttgcctaa acctctgcac atccattctt cgactggttc acgaggacac ataccacatg     1980

caacagtgcc tacaggagcg agtacaaaac tgtgacagga tcaggacagg ccaaggctcc     2040

atataccttc agagggtaca gcacaagcaa ctggagcaga agctgaagca agcagaggcc     2100

tggtggctgc agctgggaaa gtttgcccgc ctggttgact acatgatttg tcagagcctc     2160

atttctgtct tggaagagca gataacctct tttgtggcca acatccttca agccccaagg     2220

cagaaaccct ttctctcatc acagctggtc tttgatgatc atggtcaact gtctcatgtg     2280

ccctgtgttg aaaatatgat ccagactcta actggaggcc tacagtctgt caagacctct     2340

gccttgcagg tagtgcagtc tgcagacctg aagacctcct cggattccct gtattctgaa     2400

gaagaagatg aagaggagga ctcaaaagac gaatttctga tgcccaagtt ccagggccag     2460

cccagcgatg ctgtgagcat cttctgtggc ccgaatgtgg gattggtgtg gccctggaag     2520

tctcacccaa ttgctggtat cttggaggtc cgtggatgtc ggctgcgggg ccaatacttc     2580

ccccacaatt ataagcagct ggaggaagac ctggacaaca accctaagat ccagcaggca     2640

ctgaatatac aacaggtgct gctggagggc gtgctgtgca aggtgcagga attctgcagg     2700

gaacatcatt ggataacagg catttatgaa ttcctgcaat cctgggggcc tcagaagctg     2760

gaagacatga gaggtggtcc catcaagaac tacgtgacgc tggtgagccg cctgaatgtt     2820

tggcaggccc gtgtctccag tatgcctatc gagttgctca caaaaggcgg gttgctgcta     2880

cttagctgcc atgatgtaca ggcagagatg gaatccaagc tgaacagcat aaggaaggac     2940

attcttgcac acgtgcaaaa tgagtgctgg aacctcagtc aacaactcat gacagagctc     3000

acagatttca tgcatatctt ccgaaccatc aactcagata ttcatgccat tgcacagtgc     3060

acccagaagt tgaatgaagc caatgaacag tacgtcgagc tggaggagcg aatggaatac     3120

gtacgggcac tccacgaact catccgcaac cactttagcc tctttagtgc tgagaatgaa     3180

gcactggaca tctcggtgag aaggcaattc ggggagtcac ccatccctcc ctgccctcct     3240

cccccacaac cacatctact ccactgccct ctgcttgccc cacagcttct ggatatgtgg     3300

gaggcatttc agtttgagaa aagccaggct tcagagttcc tgctcagcaa gcgacatgcc     3360

attatgccca agctgcagca gctgatggca gcagcattgg cagagctgga aggcctgctt     3420

gcgaaggccc tctccggtcc ctttatggac cccacacaag atcagaggag tactgagcac     3480

cagctcgtct ccctagagcg tcagttccag aacacagtca gcgacctcag tgaactgcac     3540

cacgcctatg ccatcttcac tgaggatgag actcctgtgc ccttgccaat ctgtgggaca     3600

cgtcctattg tgcagcagca gcgcatatgg cacctgtacc gagtcatctc cgaaaacatc     3660

agcgagtgga agtgcatggc ttttgccaag ttcagcccag ctatggccca ggagaagaca     3720

gagggctggc tgacagaggc agcacggatg agcacaaccc tggagctgca cagccccgtg     3780

ctgcagcact gcatgcgcat cctgggggag tttcgcagct acctgcccct gctcactaag     3840

ctgggcagcc tccacccaca gagcctcaac tgccagtgtc tcctgcgtgc ccttgggctg     3900

ggcagtctcc aaactataga actcctaacg ctgggccagc tgcttactta tccactgctg     3960

gagtttgcag atcgaatcaa ccaggtctgg cagaatgaaa atgaacgaat tcatgcccaa     4020

gagactatac ggcggttgca gcggtactgg gaagcgcgcc agctgcgcct gctcaacttc     4080

atcctgcatg taccctacga gcccccagcc tcagagcgct ccaagaggca ggtgctccgc     4140

agcccccaat gggaggtagt ggacaaagat agtggcacct tcatcctctc agattacagc     4200

aacctgcagg attccatcca ggaaagtctt caggtgttgt ccaagatctt ggccatcgaa     4260

aagtcaggag atttaaacaa aatagctttg gagtgggtgg ccatcatgca tggcctgggt     4320

gccctgctgg aggtgtggct gactttccag cagaagtgga tttttctgaa taaagttctg     4380

catgagatga agatccagtt tcctaatgct gacctgaact ctcgtttcaa ggtcatggat     4440

gaccagtatc gaaccctgat gcgcatctct gtagctgacc ccatggttct gtcacttgta     4500

gtgcccagtg ccgagaggag cccttacttc caaggccagc agctgcaaca actgctgcaa     4560

gcaggatcgg tggagctgga gggcatcatc atgagtctgg agagcgtgct ctatggggtg     4620

tgtgctcact tcccccgcct cttcttcctt agtgacagtg agctggtagc cctgctggct     4680

gctcgactgg aatcatgcga agcccagcta tgggtacgac gctgctttcc tcatgtgcat     4740

gctgtgagct tcaggtcttg cccaactggt gagaaaaaca cagatgactg ggagtcaagc     4800

ccaaacacac agactcaggt ggaggcactt gcagtgctag gggcaggtgg ggaggaggtg     4860

aagctgcagg gtccccttcc tctgcatcca gatctcccta agtggctggc ctctctggag     4920

aagtgtctgc gcttggcact ggtgcacatg ctgcagggct gtgtggctgc tcgccttgct     4980

cgaggcccat ctctaggtga ggccctcaag caactgccca agcaaaacaa gttgtacctg     5040

caactgtatg tccagcactg gatcgactta gtccaggcct tcccatggca gtgtgtgctg     5100

gtggcagagg aggtggtatg gcgggccgag atggaggagg ctctgcttga gtggggtacc     5160

ctggccatgg tctccatgca tatgcgcaag cttgaggtac tggtgaattt tatgcgggcc     5220

cagagggctt cccaaggtgg gcagtccctg ccttctgtcc gccagaccag ccttctcagt     5280

gccctgctgg tcatggcagt gactcaccgg gatatagcac agctgctgga acagcaccag     5340

gtcagtgatc tcacagactt tcactgggtc cgccaactca agtatcactt gggttcacct     5400

cacataatcc ccaaaagccc cctacagagt cttaagacta ttgcatcttc tgaaccctct     5460

ctgtcaccag cggcatgctg gatagatgtg ctaggcaggt ccttcctgta caattacgag     5520

tatctgggac ctagactagg gcctctaccc agcctactgc ctgaacggcc agccctggta     5580

ctattattgg ccctagagga ggtggcctgt gggaccgtac tgggtcctaa tggtgtgggc     5640

aagagagcta tagtgaacag cctggcacag gccctgggcc gccagctggt gatgctaccc     5700

tgctcacctc agatagaggc tcaatgcctg agcaactatc tgaatggtgc cctgcagggt     5760

ggtgcctggc tgctgttgga gaaagttcat cagctgcccc ctggcttgct ctctgccctg     5820

ggccagcgcc tgggtgaact gcaccacttg tatgccccac tgtaccagga ggcttcccga     5880

aacacaagca ccatagaccc cacccagccc cagctccttg gcagtagctt ctttgaaaaa     5940

catcacgtgt ctgtgcgcct tggctatggc tgtctcctgg tactgcgtgc cctgagctct     6000

gctgtgcctg ccaacctgca cctgctgctg cggcctgtgg cattggcatt gcctgatctg     6060

cggcaagtgg cagagctgac tctgctgggt gcagggatga gggatgcctt ccagatggct     6120

acccgcctat ccaaattctt ctctctagag cgtgagctgg tgtctgggcc cctgccctgc     6180

cgcctgccac tgctcaagca gatactggaa gacacaatac ggacactaaa tgtgaccaag     6240

gaggaaccga agtgccagaa gcctcgcagc ctagctgcca ttgaggaggc tgccctactg     6300

cgctcaccac tgtttagcat tctcaatggg ctccacctgc acaacctccg agggctgttg     6360

tgtgcgcttt tccctagcgc cagccaagtg ctggcagaac ctatgactta caagctgatg     6420

aagccattgg tggtggagga actgcaacag gtaggtctgg atcccagccc tgacattttg     6480

gggtccttgg aacagttgag ccaggccctg agccgggcct caggcattct gctcctgggc     6540

cctgcgggca gcggcaagac cacttgttgg cacagcttat ttaagatcca gaatcggctg     6600

gcagccatgg aggacacctc aacccaaggc tgccagcctg tggaaattac ccacctgtac     6660

cccagtggcc tcagccccca ggagttcctg ggatggctag agggctcctg ctggcatcat     6720

ggcatctttc ccaaggtact tcgtgcagcc ggtcagtgta acaacatggg ccaaaagagg     6780

cagacagagg aatcaatcgg gatccagcac tggataatat gtgatggagc ctccaatggt     6840

gcttggctgg actccatcac ttgcctcctg agtgagcttc cccagcttag tctccccagt     6900

ggacagcaga tagcacgacc cccaggcacc tttctcttga tggaggtggc tgacacaaca     6960

ggcatatccc ccacagtggt aggctgttgt gccctagtct ggtgtggtgg agagcagact     7020

tggcagtgta tacttagtgc cctgatggca tcccttcctt atgagtaccg cctgcagcac     7080

cggacagtcg ctgagctcaa ccacatggct gaggttctgg tgcctgcaac attgcgattc     7140

ctcacctgcc aaggtgtcag ctctctgctg caggtacacg ggcagcaggc tgtttgtgca     7200

ggtgtggcag aagttaccag catggcacgc atcttgcata gtctgcttga cctccacctt     7260

cgcctaaagg aggagaaggc ccctggccca gaggacctca gctatagtga tcctgtggcc     7320

caaagcttca ggtcttcaaa aagcagcttt ctaaaccggt cccaggttga cagtgacgat     7380

gtgccagata agtgcaggga acacttgctg gctgtcagca gttttctttt tgccttgatc     7440

tggggctttg gagcccacct tccctccagg ttctggccca tctttgatac cttcataagg     7500

gattctatta gtcgcctctc caactaccct gagccaccac cctcagcctt ggtgtttgat     7560

ctacatgtaa gccctgaaga tggaacactg gtccccttca ctggccaata cctgagcagc     7620

cacatcaaag gaactttggg cacctttcac ccttctatcc agactgaacg gctcttgtat     7680

gtggtggacc tgcttctgtc agggggacag ccagtgttgc tggctggaga ggcagcaaca     7740

gggaagtcag cctttgtgga ggtgctggta gagccacatc acccttacat atacagcccc     7800

atccaccctg ccttcagttc ctcccacctc cgtctcctgc tgagcagagg aatccagggc     7860

caaacacaag ccagcccaca gcctgggcat caccaggatt ctaaaccctc cctcctcttc     7920

ttgctggagg acctgcacct agccacttct gacccagaga agagctgcca gccagtgttg     7980

gagactctgc gccaggccat ggatggcact gtgtatgccc acagcacctt ggaactgcag     8040

acgctgcagc ctacagtcaa cttccttgcc actgtcacag tgccaggata ctgtgagcgc     8100

ccactgtgtc cacgcctctt tcgactcttc acagtcctgg ccctggaaag catgacccag     8160

gccaccctgc tggaaagaca tgtgcctatc attcaggctt ggcttgagcg tttcccttct     8220

gtggaacggg agcgtgctct ggcacgaggt ctggttaggg cctcagtaga ggcctgggag     8280

gctgtgtgca attgcttcat gccttcaccc ctccacccac actaccactt ctccctacac     8340

tctgtgagcc acctactgag cagcctgcag ctgctgccca acagaacagg ctcccgaggt     8400

tttgtggact atcccaacca ccaggagcac ttgcgccggg tgtcaggcct gcgaggcact     8460

tgtctgaccg ttatgatggc cacacgcaat gtggtgcgtc tttggttgca tgaggcacag     8520

agaacctttt gcgaccggct ggacagcccc agggaacgct cctactgtgc caagctgctc     8580

ctagtagtag ctcaaagtgt cttctgctgt gggccagggc cccagcacct gggcaaggac     8640

catcaggaga gtgaggagga ggaggaggag gagagggtgc ccgaagtaga atctgaaggg     8700

gagttggccc agtgggagga cttcagcaac agcaatagtg aaacagagga ggaagaggaa     8760

ccttatggcc ttcaggtcgc cagagtctca aactccagag atccaagtct aacaccatcc     8820

ataggaccag taagcagggg gatgaaggaa agcataagtc acaagataag gcaagagaaa     8880

ggcacaaggg catccaacta taggctccag gtaaggagat cattcaagac ttggtggcag     8940

aagaaacccc agatggacct gatctcaccc ttgttgttac cagtgttact actacatccc     9000

caggaaaagc cctcagacct ggtcttcagt caggagctga tactggggcc taactctgag     9060

acccccaact tgtacctgga acgacagtgg gagaagctag aggagcagtt ggccacctca     9120

gctgctcaac tgaagttgag cccccacctg gcccggtgtc attccatggc ccagcacgtg     9180

gcccgcctgg tccgggtgct ggccaggccc cggcagcatg gcctgctgct ctcgggggct     9240

ctgggtactg ggcgccacac tgccatcact ctggcttcta gcatttgtca ggcccatttc     9300

tttcatctac catctgggtc agaggaggcc attctccaat gtctacgaga tgccagctgg     9360

catgctggca tgttaagcca gccagtggct ctgttggtac ccagtggtgt ggatctcact     9420

acacttcatc gcctcctggc cctggcaacc tcaggcagtt tccctggcca gtacacagaa     9480

gcagatttgg accgcattgg agaacacctc cccagggaga accttggtgt caaacagaac     9540

atcaagaagg aaatggtgtt gcagaggttc caccagcaag tgtgcagcca ccttcacctg     9600

ttcttcctga ttggagataa acaggcccac aagcagctgc cctccaccct tttcctgagg     9660

ctccttcaac tggccactgc cagcattgac cgctatgaac cctgggacca agctgccctg     9720

gccaaggtgg cccagcatca cctggagggt gctcagagtg tgccccttga tgacggctcc     9780

tggaagtacc cagacctcca ggcctcaatt cccagtgtgg ccaaagccat ggctcttatc     9840

cacctttcgg ccacccacta ccatgagcac ctgtgccctg cattgccact cgtcaccccc     9900

aagaccttcc tagacttcct ggacactttc ctgatgctgc agcaacagac aatcctgaag     9960

attaagaaca aggcccagcg ggtccagaat gccttggaga atctgagaat gctgattaag    10020

gagcacggta cccatgccaa tctgatcttt gacttggaac agcagctgaa agactccggc    10080

aagagtctca gcatgtttca gcagcagcta gagcaaagca agctcctata caagcagcag    10140

ctggaagagt gtcggcatca agagaacctc attgagaacc tggccaggca acgggatgcc    10200

ctgcaagctc agcgagaggc tttcctggag cagatgagca aggcatttct ggagcctctg    10260

agccagctgc aggtggctga ctttgaggag atacggagct atcgagcacc accagaatct    10320

gtggtccggg taactgatgc aatgtgtgac ttgttccacc atgaaacagg ctgggccagt    10380

gccaaacagc tgttatgcac tgaggatttt tatcaggagc tggtgttctt ccccaaggag    10440

aagataacag actcagagct gataaagtta catctaattc tgaaggctcc aggtatggac    10500

gatgcagccc tgcgggcagt gagccgacct gcagccagcc tggcagcctg gctctgggct    10560

gttctgcact atgggctggc gcattgccgg ggactgccca cggacctgct gctgcagcaa    10620

gtggaggcaa cactcactcg ggagcaggcc cgcctgggct actaccagtt tcaggcccag    10680

gagaccctgg agcataattt ggccctggct aagatggtgg aggatgccca agcttcccac    10740

aactgcgtgg caaagaccct cagtcaagca cagtgtgggc agtatcacaa atggcccatg    10800

aaggctgcac tgctcacgcc tatgcgtgcc tggactacac agctccagaa gctgaaggga    10860

cgctgcatga ctgtgtttgg agataccctc ctatgttcag ctgccatcat ctacctgggt    10920

cccttcccac cattgcggcg ccaagagcta ctggacgagt ggttagctct gtgtaggggc    10980

tttcaggagg ctctgggccc agatgatgtg gcacaggcac tgaagcggaa gcaaaaatct    11040

gtcagcatac caccaaagaa ccccctgctg gctacacact ctcccttcag tattctgtcc    11100

ttgctgagct ctgaatcgga gcagtaccag tgggatggaa acctgaagcc acaggcaaag    11160

tcggcccacc tggcaggctt gcttctgcga agccccacac actacagtag ttgccgttgg    11220

cctctgctgc ttgaccccag caacgaggcc ctcatctggt tggacccgct gcctctggaa    11280

gagaatcgat cttttgcgcc agccctcact gagggtagag ggaaaggcct catgagaaat    11340

caaaagagag agagtaaaac ggacatgaaa gaggaagatg atgagagtga agagagtaat    11400

gaggctgagg accagacaaa agagcagaag gcagaggaaa gaaaaaatga gcaggagaaa    11460

gagcaagagg aaaatgaaga gaaagaggag gagaagacag agagccaggg gtcaaagcca    11520

gcctatgaga ctcagcttcc atcccttccc taccttagtg ttctttcagg tgctgaccca    11580

gagctgggtt ctcagctcca ggaggcagct gcttgtggcc tgcctgtgtt actgaccaat    11640

gtggagctgg gtctagggtg cgaagaactg caatggctgc tgcaacggga gcagctgagt    11700

ccaccccagg tgcagcctgg cttctgtctg tatctcagca ccaccctctc cctctgtgcc    11760

atggaaaaag tgctaggttg tgaactgcta aaggggctga atgtgttgga tctgggcctg    11820

aacatggaaa tactggaaga acagatgctg catgaaatct tgtgcagaga gtatcctgaa    11880

ctcgagaccc gctggcagga cctaaagatc agagccctag atacctgcaa ggctgtggag    11940

gctgctgagg agcggctgct gacgatgctg ctgttccaga atccgaagcg tcagaagcca    12000

gccaagtttc tgcggaacat agtgagggcc caaggaaagc tatgccagct gcgtgctcat    12060

tgtgaagagt tagaagggca gaaactacag gagatggtat tgtgggcacc ctatcgacct    12120

gtggtttggc atggaatggc catggtaaag gccctaagcc aactgcagaa cctgctgcca    12180

cttttctgta tgagcccaga gaactggctg gcagtcacta agcaggctct ggacagcatg    12240

aagccacgtg agattaatca cggggaggac ctggccagcc atctactgca attgagagca    12300

cacctgaccc gccagctgct gggcagcacc gtgactgcac tgggccttac ccaagtaccc    12360

ttggtgggtg cattgggcgc tttggctctg ctgcaagcaa cagggaaagc atcagagctg    12420

gaaagactgg cactctggcc tggactagca gcctctccca gcacagtcca cagcaagcca    12480

gtctcagatg tggctcgacc ggcctggctt gggccaaaag cctggcatga atgtgagatg    12540

ttagagctgc tgcccccatt tgttggcctg tgtgcctccc tggcaggcca ctccagtgct    12600

tggcaggctt acctgtcact gtcatccaca gtgctgggtc ctgcacctgg gccagggcct    12660

gagccactca gcctcctcca gaagctgatc ctgtggcgcg ttctgcgacc tgagtgcctg    12720

gcaggtgccc tggcagactt caccactagc ctcctgggtc ggcccctgga tgaaaacacg    12780

tatgctccca ccatgccctt taaacatagt caggctactc agcccatgct gatcttgttg    12840

ccaccgcctg gccacccctc agccactctg catcctctga ctgtcatcca gaaactggct    12900

gccaagtatc agcaggggca gaagcaactg caggtgatag ccctgggctc tgaagcctgg    12960

gacccagtct cagttgtggt cagcactcta tcccaggcta tgtatgaggg gcactggctg    13020

gtgctggaca actgtcatct gatgccccat tggccgaaag agctgctaca gctcttgctg    13080

gaactgttag gcagagccaa ggtggttgca gacctggaat cagaacagct tttagaccaa    13140

cctgaaagca ggaatgtaag cactgttcac agagattttc gtctttggct tattgtgcct    13200

gcagagtcta gtgcttcttt gccagctgtg ctgactcagc actccatgcc tgttttctgg    13260

aaccagtccc tggagctggg ccatgttttg attgacagtg tggagctagc ccagcaagta    13320

ctctacatgc aaccccccac ccaggcacta cctctgctcc tcctccatgg cctcctgcta    13380

caccggcagc tctatggaac aaggctgcag gcacacaggg ggcgctggag tcaagtgact    13440

ctaacccagg ttcttcagac ccaagaccag ctgtgggcaa gtcttagcaa tccccgtgct    13500

gccatgcaag agctggctgc ttcagttttc tacgggggtc ctctggggga cactgaggac    13560

agggaggccc tgattagcct cacacaagcc tgcctgagcc ccagtagtgg gagctgggtc    13620

cagccacaca cacctcagtc tttgctggcc acgctcatgc ccctcccaga gctaagggag    13680

ctggatgcaa tggcagagtg caaggcccag atgcacctac tgccctcacc acctgaaccc    13740

cggctctgcg gactgagtga gggcccccaa gcctggctgt tgcgacgcca gagtcgcgct    13800

ctcttgagtg cgctgcagcg gagttcaccc gtgtgggttc ctgagtctcg aagaggcgcc    13860

cagcttgcgg aaaggcgact gcggcaacgc ctagtgcaag tcaaccggag gctggagtca    13920

ctgcaggatc tgctgaccca cgtgattcgc caagacgagt ccgacgcccc gtggtcagtg    13980

ctggggccaa atgcacggcg gcctctggag ggcgtcttag agaccgaggc tctagaactg    14040

agccagttgg tgggcacgct acaacgcgac cttgattgcc tgttgcagca gctgaagggc    14100

gcacccccgt gcccctcccg ccgctgtgct gcggtggccc acgctctctg gactggccgc    14160

ctacccttgc cttggcgacc tcatgcgccg gccggtccgc agccgccctg gcactggctg    14220

cgacagttgt cgcgccgtgg gcaactgttg gttcgttact tgggcgtggg cgcggacgcg    14280

agcagtgatg taccagagcg cgtcttccac ctgtcagcct ttcgccaccc gcgccgcctg    14340

ctgctggcat tgcgtgggga agctgccctg gaccagaatg tgcccagctc gaatttccct    14400

ggtagccgag gctcggtctc cagtcagctc cagtataaac gtctggagat gaacagcaac    14460

cctctgcact tcagggtgga gaatggtcca aatcccacgg ttccagagag agggctgctg    14520

ctgatcgggc tacaggtcct acatgcggag tgggacccaa tagctggagc cttgcaggac    14580

agtccttcca gccaacccag ccctctgcct cccgtcagca tcagcacaca ggccccgggc    14640

accagtgacc tgccagcccc agccgacctg actgtgtact cgtgtcctgt gtacatggga    14700

gggccccttg gcaccgctaa gctgcagagc aggaacatcg tgatgcatct gcctttaccc    14760

accaagctca cccccaacac ctgtgtccaa aggagggtcc atgtgtgcag cccacccctg    14820

tcttgagccc gtctaccaaa ataaagttgt agtgattcca tg                       14862


<210> 320
<211> 1490
<212> DNA
<213> Homo sapiens

<400> 320
gggccacgcc gcgcgccgat tggtggcgtc cgggactctc cctgcaggtg actgacggcg       60

ccggccgccc ctgcccgtcg cccgcccgct gctgccgccc gcccggggtg tggagcccgg      120

ccgctgctcg cgggctgagt gtctgtcgct gctgccgcct ccacccagcc tccgccatgg      180

acctcttcgg ggacctgccg gagcccgagc gctcgccgcg cccggctgcc gggaaagaag      240

ctcagaaagg acccctgctc tttgatgacc tccctccggc cagcagtact gactcaggat      300

cagggggacc tttgcttttt gatgatctcc cacccgctag cagtggcgat tcaggttctc      360

ttgccacatc aatatcccag atggtaaaga ctgaagggaa aggagcaaag agaaaaacct      420

ccgaggaaga gaagaatggc agtgaagagc ttgtggaaaa gaaagtttgt aaagcctctt      480

cggtgatctt tggtctgaag ggctatgtgg ctgagcggaa gggtgagagg gaggagatgc      540

aggatgccca cgtcatcctg aacgacatca ccgaggagtg taggccccca tcgtccctca      600

ttactcgggt ttcatatttt gctgtttttg atggacatgg aggaattcga gcctcaaaat      660

ttgctgcaca gaatttgcat caaaacttaa tcagaaaatt tcctaaagga gatgtaatca      720

gtgtagagaa aaccgtgaag agatgccttt tggacacttt caagcatact gatgaagagt      780

tccttaaaca agcttccagc cagaagcctg cctggaaaga tgggtccact gccacgtgtg      840

ttctggctgt agacaacatt ctttatattg ccaacctcgg agatagtcgg gcaatcttgt      900

gtcgttataa tgaggagagt caaaaacatg cagccttaag cctcagcaaa gagcataatc      960

caactcagta tgaagagcgg atgaggatac agaaggctgg aggaaacgtc agggatgggc     1020

gtgttttggg cgtgctagag gtgtcacgct ccattgggga cgggcagtac aagcgctgcg     1080

gtgtcacctc tgtgcccgac atcagacgct gccagctgac ccccaatgac aggttcattt     1140

tgttggcctg tgatgggctc ttcaaggtct ttaccccaga agaagccgtg aacttcatct     1200

tgtcctgtct cgaggatgaa aagatccaga cccgggaagg gaagtccgca gccgacgccc     1260

gctacgaagc agcctgcaac aggctggcca acaaggcggt gcagcggggc tcggccgaca     1320

acgtcactgt gatggtggtg cggatagggc actgaggggt ggcgcgcggc caggagcacg     1380

catggtattg acttaaaagg ttcattttgt gtgtgtgcac attgtgtgtt ttgtgtactc     1440

ctgtgggact cccatggttg taaataaagg tttctctttt tttttcctag                1490


<210> 321
<211> 6662
<212> DNA
<213> Homo sapiens

<400> 321
actgaccccg ctgtaccacg gccctcttgc ggacagcccc ggggacgtcg ttgggacatc       60

gctgggaccc cgggctctgc agccacaacc atgtttggcc ggaagcgcag tgtctccttt      120

gggggcttcg gatggatcga caagaccatg ctggcaagtc tgaaggtcaa gaagcaggag      180

ctggccaaca gctcggatgc gaccctccca gaccggccgc tctcccctcc tctcacggca      240

cctcccacca tgaagtcgtc ggagttcttt gagatgctgg agaaaatgca ggggatcaag      300

cttgaagagc agaagccggg accccagaag aacaaggacg actatatccc ataccccagc      360

atcgacgagg ttgtggagaa gggaggcccg taccctcagg tcatcctgcc acagtttggg      420

ggctattgga tcgaggaccc ggagaacgtg ggcaccccaa catcgctggg gagcagcatc      480

tgtgaggagg aggaagagga caacctcagc cccaacacat ttggctacaa gctcgagtgc      540

aagggtgaag ccagggccta ccggaggcac ttcctgggga aggatcatct aaacttttac      600

tgtaccggca gcagcctggg gaacttgatc ctgtccgtca agtgcgagga agcagagggg      660

atcgagtacc tccgggtcat ccttaggtcc aaactgaaga cggtacatga gcggatcccc      720

ttggctggac tgagcaagct tcccagtgtc cctcagattg caaaggcttt ctgtgatgat      780

gcagtgggac tgagattcaa tcctgtcctg taccccaagg cctcccaaat gattgtgtcc      840

tatgatgagc atgaagtcaa caacacattc aaattcggag tcatttatca aaaagccagg      900

cagaccctgg aggaggagct atttgggaac aatgaggaga gcccagcttt taaggagttc      960

ttggacctgc tgggggacac gatcacactg caggatttca aaggtttccg aggaggcctg     1020

gacgtgaccc acggacagac aggggtggaa tcagtgtaca caacattccg ggacagggag     1080

atcatgtttc acgtttccac aaagctgcca tttaccgacg gagacgccca gcagctccag     1140

agaaagagac acattggaaa tgacatcgtg gccatcatct tccaagagga aaacacgccg     1200

tttgtcccag acatgatagc ctccaatttc ttacatgcct acatcgtcgt gcaggtcgag     1260

accccaggca cagagacccc atcctacaag gtctctgtca ctgcgcggga agatgtgccc     1320

acctttggtc cacctctgcc cagtcccccc gttttccaga agggcccgga attcagggag     1380

tttctgctca ccaagctcac caatgccgag aacgcctgct gcaagtcgga caagtttgca     1440

aagctggagg accggaccag ggctgccctc ctggacaacc ttcacgatga gctccacgcc     1500

cacacacagg ccatgctggg actgggccca gaggaggaca agtttgagaa tggaggccac     1560

ggggggttcc tggagtcttt taagagggcc atccgcgtac gcagccactc catggagacc     1620

atggtgggcg gccagaagaa gtcgcacagt gggggcatcc ctggcagcct cagcgggggc     1680

atctcccaca acagcatgga ggtcaccaag accaccttct cgcctccagt ggtggcggca     1740

acggtgaaga accagtcacg gagtcccatc aagcgacgct cggggctctt cccccgcctg     1800

cacacgggct cagaaggcca gggcgacagc cgggcacgat gtgacagcac atccagcaca     1860

cccaagaccc cagatggtgg acactcctct caggagataa agtctgagac ctcatccaat     1920

cccagctctc cggaaatctg ccccaacaag gagaagccct tcatgaagtt gaaggaaaac     1980

ggccgtgcca tctcccgctc ctcctccagc accagcagcg tcagcagcac tgcaggggag     2040

ggcgaggcca tggaggaggg cgacagtggg ggcagccagc cgtccacgac ctcacccttc     2100

aagcaggagg tgtttgtcta cagcccgtcc ccgagcagcg agagccccag cctgggggca     2160

gctgccaccc cgatcatcat gagccggagt cccacagatg ccaaaagcag aaactccccg     2220

agatcgaacc tgaaattccg ctttgacaag ctcagccatg ccagctctgg tgcgggtcac     2280

taatgtgaaa gtggagtcct tcgcctgtcc aagggaatcc cctcttctgt cctggaaaag     2340

gctcctgtac cagcagtttg ggagtgccgt ccacgaccct gacagtccca gccctgctgc     2400

cccatggcca cgtgcccaca gatgtgctgt tggtccaggt gtcccagtct ggccacagcc     2460

ctgcctccgc cctcacctac atgccctccc agcccctccc atctctggac gaggcctcct     2520

tcctcaggtt cctcctgctc ctgacctccc agtgtgatgt ccgggtcctt tatcatccta     2580

ttcatcctgg agaggaaaag tgtcgggcaa agggggatct ggggggagct cagcagtgac     2640

tggggagctg gtctgcctca gagacagagt agggggtggg agcagagcct cggtgagggt     2700

cttggccaca gggcagtgcc ttcctgaacg tggcaggctt tactaccagg aacgcactcg     2760

gtggtggagg ccccatgttc ccaggagcca agattcgtag catccttgag gccatcctga     2820

taaaattcgg cgctattgcc cccgtagctc tggagctcta aaccgtctat ctgcttctgt     2880

gctgaacgcc tttcccatct gctgacgtag gcccagggct gccctgcccc tgctgccagt     2940

gtaccgtgag cggggctcca gccagttcaa gctcagagcc agagctggac gggccagaac     3000

tgcgctgcac acttcctgga ctgaggcggg gactttgggt cccacccggt ttctcctgat     3060

tatggctgct gtggggtgag gggagggagg ggcagccccg aggcagtctc ttccctttga     3120

gaagatattt tcccacaaag gggtgggaag ccaggagtga gaaggaattc agggagagca     3180

aaggagccag tgctgagatg ctgctgtgtt ggttgaggaa aacctcgggc ctgagggcca     3240

ggccggagcc caggtctctg ctgacaatgg gggttcaagg aagacgtcgt tatctcccct     3300

ccccacttac tcgaggagag aggtgagggg gggatgactt gcgggttctg atcaggcccc     3360

tgggtgggga aggggcacag tgtccctcag cagcttacgc ccctggagtc ttggggggcc     3420

cagcctggcc ctggggcctt ttccagctac tgtgcccttg ggcagctgcg tctggggctc     3480

aaccccccaa tcctgttccc ctctccagct gcgggtctgt aggcagctgt cacatctgaa     3540

gggtttctgc aacctggacc ccatctgggt gtgggtcaga ccctgtgacc cacatgccac     3600

ccccaccctc cacagagccc ccttgctggg acagccagct cacctccaag gacatcccct     3660

cctggcttct cccccttccg agtctgcagc gccgtgggct tctctgccga tgggcccggg     3720

ttggggttaa ggtgggcatc ctccaggtac aacgagcctg aagagcccct ttcagtgcag     3780

acggggctgc agagtgacac tggctgggca cctgccccac gaccaatgac aaggatttcc     3840

agctgaatgc tttattccca tagggatctg gacctgtgcc caagatataa atactacact     3900

tttttttttt ttttttaact gacattgtga aattctccct atagcttttg ccattcaagc     3960

aacattgtga tctttcttcc ccgccacgtg tgtgggaatg attgagtcct gtttgcaagc     4020

tggagaggag ctctcccttt gctagtactt tctctaaagt actagtctag taaaatttat     4080

tcttgttaga aggtcaacaa aatatctgtt tagcttttat gaagagtcac cgtagcagcc     4140

cccacggctg gaaagaggcc tgtacgttct ggacgcgttt tgttggctgg gcttctggag     4200

gcactggcaa ggtcaaactg catttcttta agaacagttg caggatctgg ctcgcctctg     4260

tgggaagccg gcattacagg tgcttggtgg atgggccgtg tcacattgcc atctggggtc     4320

ctttggggtt tccaggttgt caccatgctg tcccatttgg gaatcccata cctgcctgtc     4380

cccactgcgc tggctgaccc ttgctgcctg ctgcctcttg ggagggcttt gtccctgcct     4440

ctgagctggt gggcaggatg gctgggtggc ccccagagaa gcacagacct gagatggggt     4500

ctccatgccc ggtttgctgt tggaatgatc tgaacaggac cccaaatgcc tcttccctct     4560

ggtcatgcct cactatctct aggagctcca tcctgtggct tccagagtgt gcacttccag     4620

cccacccggg cagtgctgag agggaggagg agaacaagga tggcccagcc tcccctccct     4680

cccctagacc acggggcggg cagctcgggt tcctggaggg ctgtttcccc cacgctgtcc     4740

ctacatctgc tctgatctaa aatgtctttc cttttatgct gcgcccagtc ttggggctca     4800

aagatttgcc caaacctcat tggccctcgt gactaggctc atctagatgg tgctcacgct     4860

ggtgtttgag gcatttccac tgtgatctcc acgaggggat gttttccggg acacatctct     4920

ggctctggga actgcctgac tcactgaaga aactactttt caggcactgt agggtcaccc     4980

atatgcctcc agctcagttg acgcttaaaa acaggtgcag aaaagctcgc gatggaaggt     5040

cttaatgaga gtgtctgtct atgccaatca tgtaaaatga cgtttcttga aaaagattca     5100

gtggttcagc tttgtcagca tcatctcaac acaagcctgc tggctctttt tagcatctca     5160

tccaaccatg tcatcgtcca gatgagaaat cttagcccag gtgaggggag taacttgctt     5220

gaggtcacac agctggctgt tggcaaagct gggattagaa ccctcaaccc agggtccctt     5280

cctctgcagc gcctacatgg ttggttgaat aagtggctgc gtttcctggg gccctgggtt     5340

ttggggaagc cagttagctg ctgctttggc actggcatgg aggtgagcag tcaaggatgc     5400

tggtgaggct gcagtttctg ctctttttca tcagggggga tagtctctag gatttttcag     5460

tgaggaccct tgggctttgg atgcagcttg aaccaagaaa acgaggaggg aaagggattc     5520

agtgaactat tcctcagtgg gatcggttct tcagctcctg atgggggctg tgtaatgggg     5580

gcagaggcca gggaaaaaga tgctgttcac ccaccctcag cttccctttt cctaaattaa     5640

gaggaaaagt ggtcaaagaa aaactcttca tttctccctg attcttaaac gaaggtggtt     5700

aatagaaact caggctcccg tgacaaggca ggacaagagc ctgtttcgct ttcctccctg     5760

accctgccag gtgccaactc aaacactacc tttctcattg gtttctaagt cagtagagac     5820

agatctgttt taagcagttg ggggttcgag tagatctcat gggtacagga ggccagcagg     5880

gaccaggcca gtcagccatg ctcaggaccc ctcggctcct cccccagcct ctagctaccc     5940

tgtatcgagg caaggggagg ccagtaaagt ttgccaagcc tgatcctgca gcctggtggg     6000

gctggctggg gtattctttt accaaactct gttttaccgc cagccccttg tacaccccaa     6060

tcccatgtct ccctcccttc agctggaccg tgtgcccctt tgggaggaag aagacaagcc     6120

ccactagggc caagggcagc agagccctgc cgagtgagag gctgtggggc agcggctctg     6180

tcctgtgcct taccagccct ggggaggggg gcatttggct ggaagactgg aatttaattg     6240

ccatcgtctt tgattttgtg acatttctgc ttggaagtgt gaactacccc cccccccccg     6300

cttcctgctc cttagcatgc gtgcagctct ctcctgtttt gggtgttccc cttggacact     6360

ccagctcggg gactgctggc gtgtgaatgt gcagattccc ctgtgtggtc gaacctaaga     6420

actgtggctt ggaagtgatg ctccatgtga cgacgacttt gctttctttc ctcttagtga     6480

ggaggtgatt cgtagatccc aactgcctat gtaatgtaaa taatgtacat ttaatttatt     6540

gctatggtag cacattgtat ttgttaatgt acaaaacaaa ttctaaaagg ttgacaaatg     6600

tatattttgt tgcttaaatg tgtctttgca gaaattgaca ataaataaca tattttgtgt     6660

cc                                                                    6662


<210> 322
<211> 1335
<212> DNA
<213> Homo sapiens

<400> 322
aaaagaggtg ggatcgtttg tcgcgatgtg gagtggccgt aagctgggct cctccggggg       60

ttggttttta agagtgctgg ggcctggagg ctgtaataca aaagctgcgc gtcccttaat      120

ttcctcggcg gtttatgtga agaaccagct cagtgggact ctacagatta aaccaggggt      180

tttcaatgaa tacagaacca tatggttcaa atcctacagg acgatctttt cctgtttgaa      240

cagaataaag agtttcaggt acccttgggc gagactgtac agtacttccc aaaccactgt      300

cgacagcggt gaggtaaaaa ccttcttggc cctggctcac aaatggtggg atgaacaagg      360

agtatatgca cctcttcatt ccatgaatga cctgagggtg ccatttatta gggacaatct      420

tctgaaaaca attcctaatc accagccagg aaaacctttg ttggggatga agattcttga      480

cgttggctgt ggtggtgggc tgttaactga acctctaggg cggcttgggg cttcagttat      540

tggaatcgac cctgtggatg agaacattaa aacagcacaa tgccataaat catttgatcc      600

agtcctggat aagagaatag agtacagagt gtgttccctg gaagagattg tggaagagac      660

tgcagaaaca tttgatgctg ttgtagcttc tgaagttgta gaacatgtga ttgatctaga      720

aacattttta cagtgctgct gtcaagtgtt aaaacccggt ggttctttat tcattactac      780

aatcaacaaa acacaacttt cctatgcctt gggaattgtt ttttcagagc aaattgcaag      840

tattgtacca aaaggtactc atacatggga gaagtttgtt tcacctgaaa cactagagag      900

cattctggaa tcaaatggtc tgtcagttca aacagtggta ggaatgctct ataacccctt      960

ctcaggttac tggcattgga gtgaaaatac cagccttaac tatgcagctt atgctgtgaa     1020

atccagggtc caggaacacc cagcctctgc tgagtttgtt ttaaagggag aaacagaaga     1080

gctccaagct aatgcctgca ccaatccagc tgtgcatgaa aagctgaaga aatgaattgt     1140

ttctgagaac tatagtaata tggcttggat atctgatgtt ttcaaataca aaaatgtaca     1200

atttatcctt tgagagagaa tcatgaagaa aagaaggtca ataaaaaggg ctaaaacctt     1260

ggacaaaagt ttttgttatt tcgtctaata gctactttca agggattctg tgaataaaaa     1320

gttttgtcaa gatat                                                      1335


<210> 323
<211> 1912
<212> DNA
<213> Homo sapiens

<400> 323
gctactccca ccccgccccg ccccgtcatt gtccccgtcg gtctcttttc tcttccgtcc       60

taaaagctct gcgagccgct cccttctccc ggtgccccgc gtctgtccat cctcagtggg      120

tcagacgagc aggatggagg gctgcatggg ggaggagtcg tttcagatgt gggagctcaa      180

tcggcgcctg gaggcctacc tggcccgggt caaggcgctg gaggagcaga atgagctgct      240

cagcgcggag ctcggggggc tccgggcaca atccgcggac acctcctggc gggcgcatgc      300

cgacgacgag ctggcggccc tgcgggccct cgttgaccaa cgctggcggg agaagcacgc      360

ggccgaggtg gcgcgcgaca acctggctga agagctggag ggcgtggcag gccgatgcca      420

gcagctgcgg ctggcccggg agcggacgac ggaggaggta gcccgcaacc ggcgcgccgt      480

cgaggcagag aaatgcgccc gggcctggct gagtagccag gtggcagagc tggagcgcga      540

gctagaggct ctacgcgtgg cgcacgagga ggagcgcgtc ggcctgaacg cgcaggctgc      600

ctgtgccccc cgctgccccg cgccgccccg cgggcctccc gcgccggccc cggaggtaga      660

ggagctggca aggcgactgg gcgaggcgtg gcgcggggca gtgcgcggct accaggagcg      720

cgtggcacac atggagacgt cgctgggcca ggcccgcgag cggctgggcc gggcggtgca      780

gggtgcccgc gagggccgcc tggagctgca gcagctccag gctgagcgcg gaggcctcct      840

ggagcgcagg gcagcgttgg aacagaggtt ggagggccgc tggcaggagc ggctgcgggc      900

tactgaaaag ttccagctgg ctgtggaggc cctggagcag gagaaacagg gcctacagag      960

ccagatcgct caggtcctgg aaggtcggca gcagctggcg cacctcaaga tgtccctcag     1020

cctggaggtg gccacgtaca ggaccctcct ggaggctgag aactcccggc tgcaaacacc     1080

tggcggtggc tccaagactt ccctcagctt tcaggacccc aagctggagc tgcaattccc     1140

taggacccca gagggccggc gtcttggatc tttgctccca gtcctgagcc caacttccct     1200

cccctcaccc ttgcctgcta cccttgagac acctgtgcca gcctttctta agaaccaaga     1260

attcctccag gcccgtaccc ctaccttggc cagcaccccc atccccccca cacctcaggc     1320

accctctcct gctgtagatg cagagatcag agcccaggat gctcctctct ctctgctcca     1380

gacacagggt gggaggaaac aggctccaga gcccctgcgg gctgaagcca gggtggccat     1440

tcctgccagc gtcctgcctg gaccagagga gcctgggggc cagcggcaag aggccagtac     1500

aggccagtcc ccagaggacc atgcctcctt ggcaccaccc ctcagccctg accactccag     1560

tttagaggct aaggatggag aatccggtgg gtctagagtg ttcagcatat gccgagggga     1620

aggtgaaggg caaatctggg ggttggtaga gaaagaaaca gccatagagg gcaaagtggt     1680

aagcagcttg cagcaggaaa tatgggaaga agaggatcta aacaggaagg aaatccagga     1740

ctcccaggtt cctttggaaa aagaaaccct gaagtctctg ggagaggaga ttcaagagtc     1800

actgaagact ctggaaaacc agagccatga gacactagaa agggagaatc aagaatgtcc     1860

gaggtcttta gaagaagact tagaaacact aaaaagtcta gaaaagaaaa ag             1912


<210> 324
<211> 8375
<212> DNA
<213> Homo sapiens

<400> 324
cgcggcggcg attggccggc cgcggcgccc gctcccagaa tgcagcgcat ggcgcgtcat       60

tgaagagaga ccatgatggc ggcggcgctg gggcccccag aagtgatcgc tcagctggag      120

aacgcggcta aagttctgat ggcaccacct tccatggtca ataatgaaca acgccagcat      180

gcagagcaca tattcttatc atttaggaaa tcaaaatcac catttgcagt ttgcaagcat      240

attttggaaa ctagtaaagt ggactatgtc ctctttcaag ctgccacagc cataatggaa      300

gcagttgtcc gagagtggat tctcttggaa aaaggtagca tcgagtctct gcgaacattc      360

cttttaacct atgtcttaca aaggcccaac cttcaaaagt atgttcggga acagattcta      420

ctagcagtag cagtaattgt aaaaagagga tcattagata aatcaattga ctgcaaaagc      480

atttttcatg aagtcagcca gttgattagt agtggcaatc ccactgtgca aactctggcc      540

tgttctattc tgactgcgct attgagtgaa ttttcaagtt caagtaaaac tagcaacatt      600

ggattgagca tggaattcca tggtaactgc aaaagagttt ttcaggaaga agaccttcgt      660

cagatcttca tgttaactgt tgaagttctg caggagttca gcaggcggga aaacctcaat      720

gctcagatgt cttcagtatt tcagcgttac cttgcactcg ccaatcaagt cttgagctgg      780

aactttcttc ctccaaattt gggcagacat tatatagcta tgtttgaatc ctcgcaaaat      840

gtgctgttga agccaacaga gtcctggcgg gagactcttc tggacagcag agttatggag      900

cttttcttca cagtacatcg aaaaatcaga gaagattcag atatggcaca agattctctg      960

cagtgccttg cccagttagc ttctcttcat ggacccatct tcccagatga aggatcacaa     1020

gttgattatc tagcacactt cattgaggga ttactgaata ctatcaatgg aattgaaata     1080

gaagattctg aagctgtggg gatctccagc attatcagca acctgataac cgtgttccca     1140

cgaaatgttt taactgccat tccaagtgaa cttttctcct cctttgttaa ctgcctcaca     1200

cacctcactt gttcttttgg gcgaagtgct gcattggaag aagtgcttga taaagatgac     1260

atggtataca tggaagcata tgataaattg ttggagtcct ggttaacttt ggttcaagat     1320

gacaaacatt tccataaagg cttttttacc caacatgcag ttcaagtttt caattcctat     1380

attcagtgcc acctagctgc tccagatggc acaagaaatt tgactgccaa tggtgtggcc     1440

tctcgtgagg aggaagaaat aagtgaactt caagaggatg atcgagacca gttttctgat     1500

caactggcca gtgtaggaat gctaggaaga attgctgcag aacactgtat acctcttctg     1560

acaagtttat tagaagaaag agtaacaaga ctccatggtc agttacaacg acatcagcaa     1620

cagttacttg cttcaccggg ttcaagcact gttgacaaca aaatgcttga tgatctctat     1680

gaagatattc actggcttat tttagttaca ggctacctct tagctgatga tactcaggga     1740

gagactccgc taatacctcc agaaataatg gaatattcca ttaagcattc atctgaagtt     1800

gacattaata caacacttca aattttggga tctccaggag aaaaggcttc ttccatccca     1860

gggtacaaca gaacagattc tgtgattagg ctgttgtctg ccattctcag agtttcagaa     1920

gttgaatctc gagcaataag agcagatctc actcatctac taagtcccca gatgggcaaa     1980

gatattgttt ggtttttaaa acgctgggca aagacttatc tcctggtgga tgaaaaactg     2040

tatgatcaga taagtctgcc attcagtaca gcgttcggag cagatacaga gggttctcag     2100

tggataattg gctacctctt acaaaaagtc atcagtaacc tctcagtctg gagtagtgag     2160

caggaccttg caaatgacac tgtgcagctc cttgtcactt tggtggaaag aagagaaagg     2220

gcaaacttag taattcaatg tgagaactgg tggaatttag ctaagcagtt tgcaagccga     2280

agcccacctc ttaatttctt gtcaagtcct gtgcagagga cattgatgaa ggctctagtc     2340

ttaggaggtt ttgcacatat ggacacagaa accaaacagc agtattggac agaggttctt     2400

cagccacttc agcagcgatt cttaagagtg ataaaccaag aaaacttcca gcagatgtgt     2460

cagcaagagg aagtcaagca ggaaatcact gccacactag aggccctgtg tggcattgct     2520

gaggctaccc agattgacaa cgtagcaatc ctgtttaatt ttttaatgga cttccttacc     2580

aattgcattg gattgatgga agtttacaag aataccccag agactgtcaa tctcattata     2640

gaagtttttg ttgaagttgc acataaacag atatgctatc ttggagagtc caaagctatg     2700

aacttatatg aagcctgcct tactttgttg caagtgtatt ctaagaataa tttagggcgg     2760

caaagaatag atgttacagc agaagaagag caataccaag acctgcttct cattatggaa     2820

cttcttacta acctgctgtc aaaagaattc atagatttca gtgatacaga tgaagtgttt     2880

agaggacatg agccaggtca agcagcaaac agatctgtgt cagcagcgga tgttgtgttg     2940

tatggagtaa acctaattct gcccttgatg tcacaggatc tcttgaagtt tccaaccctt     3000

tgtaatcagt actacaaatt aatcacattt atctgtgaga tttttcctga aaaaatacca     3060

cagcttcctg aggatctgtt taaaagtctg atgtactccc tagaattagg aatgacatca     3120

atgagttcgg aggtttgcca gctttgcctg gaggccttga caccgttagc tgaacagtgt     3180

gcaaaagcac aagaaacaga ctcaccactt tttctagcaa cacggcactt tcttaagctg     3240

gtttttgata tgctggtttt gcaaaagcac aacacagaga tgaccactgc ggctggcgaa     3300

gctttctaca cgttggtgtg tttgcaccag gctgaatatt ctgaactggt cgaaacatta     3360

ctatcaagtc agcaagaccc agttatttac cagagattag cagatgcctt caacaagctc     3420

actgcaagca gcactcctcc tacgctggat cggaagcaga agatggcctt cttaaagagt     3480

ttagaagaat ttatggcaaa tgttggtggt ctcctttgtg taaaataaac aacagaactt     3540

tatgcttaat ttagatcctt tctgcaaagt gcactgaatt gctgaaagtt gacttgagtc     3600

ttgtcctatt cctcagttca tttggccatt ttggattttg gagagcctga aactttgata     3660

tgtatgtaat acagtgaaac aggagaggtc aacttggcat cagcttctgc tgttaagtgt     3720

tagccacaat ctgtcatata tatgtctttt agattctgaa tggtgattta aaattttcaa     3780

aatgaaattc catatatgtg caaacagata tgggcaccac gaaatacata tgcagtgcct     3840

tttttccttt taacataggt ggctagccaa agtttagaat ttttgtcatt aaatatgaaa     3900

tggatatatg ctaggcagtg tttctcaaaa tctccataga tcgcctgcat cacttgagga     3960

gctggtgaaa aggcagattc ttaggcccaa ctgtagacct tcagagtcag aatgtctggt     4020

tgttgggccc aggagtcttc atgttaataa gcttctccct ttcgtcaccc caaaagtttt     4080

gaatcaatga aagagacatt gaaaactctt aagaggtttt gtgctttcta gcttttcctc     4140

cctttgatga ttgggtttta taattcagca ggaaggggaa acatcaccag gggtttgttg     4200

gctttttctt agcttgcttt cttgcttgct tgctttcttg cttttcttgc tttctgtctc     4260

tctctttctt ttctctctct ctctcacatc aacccagtgc tgcaggtttt gtgtaataca     4320

agtcactaat catactctga tgcctgaact tgaggaggaa aatacatgta tatttttgtt     4380

ccgtaaaaat aaccttagga actgtagcca tttcattgcc ttaattttaa gaggaaaata     4440

caaaaacagc tgatttgttt tagtaagaaa ccacgtcttg atgcttcaga gttggtttag     4500

ggtgttagct gctatgaacc tgttgcccct ttcgatcgtg tatttatgta ggtttatcag     4560

tgaaatgaaa ggcttgtttc cgtctagtct aactttttga gtgtgtttct atccagccac     4620

atagcccata tctactctaa atggcttgct taagcaataa ttattttaaa ggatgtgaat     4680

cactgattca cacagactat tgcacgttgg ggcattaggg gcaataattc ttatccagac     4740

atgggagcca gtgaatttaa tttcagagat taaaaattca ctttagatcc tctagtttga     4800

tctcttaatc aggattttta tacagctgcc aggctcccct aattcagtgt gccagcttac     4860

aatgtggaaa tgaaagctaa tttatacaca gcaggcatat gaaactccac tcattgcagt     4920

actttcacag cacagtgaca ggtagaggac tctggcacag gtgcactcat gaaactctgc     4980

ttccaccatg ttcctgacac ctatctatta aaccattctg caaatacggt ttttctacct     5040

gattgcatat agcatatgtg tcattacatg tgatgctgtg caaaactttg tataattctg     5100

tgttattaac agttaacaaa actggagcat ctgaattaca tccaacctgt gcatgtgatg     5160

ttaggtagat gtgaatgcag ggccttgggc cataacttac atttctctca atttgattag     5220

ctttgagtca caattaaggg gaagcaaaaa catcttgaaa agactgctag gaaggaaatt     5280

aatatcagtc atccagaagt acacgtttct gtattttaaa aaatactttg atgcatttat     5340

ttttaggtgt tttttttttc cccttaaaaa acttgaagtg atatgcagca gtaatctatt     5400

tgttttgcat tgttcttggt gttttgtgtt tcccagatcc ctcaagcttt ctcagctgtt     5460

gtgaattatg tgtatctgtg tgtgtgctaa gtacagtctc tttaccaaag ggcactgaaa     5520

cacacaattg actggacagg tccacgcgcc atgacaaaac tataatcaag ttattaaaac     5580

taaagaggag tgggaaagga atgccttggt aagtaaaaag gcatctatat ttaataactt     5640

ttatccagat ggcaacatat ttgcaaaatt tgcccagatc ctattacaat actaaaaata     5700

gaaaatttca cctccatatt cctgaggtgt aatttcatta gactagtttt agtttaaaaa     5760

gaccttcttc agattggacc aaataatact tataagatca gcagaatgtt gaatattagc     5820

tcactggggt ggggagaagc cactaccatt ttttaggtga tggggatgcc actgagttgc     5880

aacggctaga ccttttcagg gtggttgtgt ccatgtttgc ctgattggat gcttattcac     5940

tttgtgtttt cttttgtttt attttgtcca attttgtctt tagctgtgtt tattaacttc     6000

tccggtcttg ttttgtttta atgctcttgg cccagtgggt gtcaagaaca ctggcttaat     6060

tcaagtcagt tgattttttt tctattaaaa ctgttgttaa aatatttttt aaaacaaaaa     6120

cattatttgt gccctctttt atatatgtca aagggacact gtcaagtatt tcatttttag     6180

atttttgttt tataaaattt ctgttgttca tatagtatcc tttaacctct agttttccat     6240

acatcctttg tttgtttctc attttatttt ccttgaccca tttatttccc aaggcacaat     6300

cactaaagac tttgtacttt cacagtctgt taatgtggta gcacctgtaa ctgtgttctt     6360

gttctgttaa aaggattgat ttgcttttat agtccttgtg ctggatgagt ggctgcctca     6420

gtagcaaaac tacctgacag tatttgacag tgtcctttcc agcaccatta tttgggtctt     6480

tcagggtggc catctctgtt agaagacagt agcatgttaa catcactgca ttgagttttt     6540

gtctggtgta aagtatgact tttaatgtaa acaaactgca ggtttttttc aaactaattt     6600

taagaattta gtcttatttc gttgtaaact gtgtatctaa ttatattaca ttactctgtt     6660

cagatgggat ggttactacc acttgtccat gattttcatt tgaaaagcaa gtatctatat     6720

catttccccc cagtcagcat tatttaacac tccccttaac tgtctttgaa ctttctcttt     6780

taacaaaaat gtcaagtctt tatagttgta atatcaccat gtttcccatt tctgttaata     6840

cttctatgaa cccctaaagt attgaaggga actagctgtc agtttcaagg attacaagtt     6900

tgagtctcct agtattcaac atcattctga accctgaaat aatatttttc tctgttaaac     6960

aatttttatc tgtttgccac ctctgttgtt agaggtggtt gtcaattgac cttactaagt     7020

tagctgtctt tgatgaggaa ttattgttat tggttcctga ataaaacatt aaccttttaa     7080

gtcagaagga acctcggtac ttcttaaggt ttgtttgtgt tttctaaaac cagagaataa     7140

ggaactgatt tggctatgag gtttaacatt ataattttct gtaagctttc ccacaaaaaa     7200

acattgttga tttgaggata taataatgtt ttaatctttt taaaatataa gtggttattc     7260

tctgacttgg taactatgtt ctgaaaacac tgcatttaag aatttttaaa aattggtttt     7320

ctaaaattaa aatgtccaaa ttaggcatat tgctgagctc aaattgatgt gaaatgccat     7380

ggttccagtt gaattttaag catattttca tttagatata aaatatatga agtatgcttt     7440

gttgattata gtgagaaccc atgacatagt taaccaaaga atatgtttgg ttcaaataaa     7500

aatagaagct taatactggg cattcatact ttttaaagag aatgaatgaa gaaatcggtt     7560

tcctgctgta gttctctatg ggtaagtctt agtaaagacg agaatgctga agtcggccgt     7620

ggcgattccc tcctaggaac tgggaggtgt ggcttgccca ttacccgctt gaagctcaca     7680

tctttaccct cctctcccac tgtggtttga tcttcaccta ttcccaggcc ctcccagcaa     7740

ttggagaggt gtcttttttt ttggttttgg ttttttttct ccccgtctgc attcttaggc     7800

ctcttagcta ttaggaactg tcagatacat actagtagct aattttccta gcctgaaatt     7860

atatactgca tctgcactat gtacctacta gggatctgac ctcaagtgtt ttctgagccc     7920

aggcttcctg gtgtggtgtc ttttaccaca taaaattatt acaaattgca aatgttggta     7980

ttgtgatttg attatctgta caaagaaaga agctctatgc agtgagtttg tggtttaatg     8040

gtcacaaaaa tgttagcact gctaccactc agcacgtgta aaatttttta aatttataaa     8100

tattaaaatt ttaaacttac actaagactt ttcagtttta tttaaagacc cagggatgag     8160

tgtactgttt aaatatttac ctctattaac ataactaatg aaggtataaa attgcattta     8220

gtttttcaga agatgctgca atatgatttt aggaaataag gctatgtatt gagccagtta     8280

taggctgaat atcaggttga taaaatttta tttgtatttt taaaattcat aaatgggagt     8340

taaaatgtgt cttttcacta aatattttta ttaca                                8375


<210> 325
<211> 2618
<212> DNA
<213> Homo sapiens

<400> 325
atggcggcgg gtgggagcgg cgggcgtgcg tcgtgcccgc cgggggtcgg ggtcggcccg       60

ggcacggggg gcagtcccgg gcccagcgcc aacgccgccg ccaccccggc ccccggcaac      120

gcggccgccg ccgccgccgc cgccgccgcc gccgccgccg cccctgggcc gacgccgccc      180

gccccgccgg gccccgggac agacgcgcag gccgcgggcg cggagcgggc ggaggaggcg      240

gcgggcccgg gggcggcggc gctgcagcgc gaggccgcgt acaactggca ggccagcaag      300

cccaccgtgc aggagcgctt cgccttcctc ttcaacaacg aggtgctgtg cgacgtgcac      360

ttcctggtgg gcaaggggct cagctcgcag cgcatccccg cgcacaggtt cgtgctggcc      420

gtgggcagcg ccgtctttga tgccatgttc aacgggggaa tggccacaac atccacggag      480

attgagctgc ccgacgtgga acccgctgcc ttcctcgcac tgctcaagtt tctctactcg      540

gacgaggtgc agattggccc ggagacggtg atgaccacgc tatacaccgc caagaagtac      600

gcggtgccag cgctcgaggc ccattgcgtg gagttcctga agaagaacct gcgagccgac      660

aacgccttca tgctgctcac gcaggcgcga ctcttcgatg aaccgcagct ggccagcctg      720

tgcctggaga acatcgacaa aaacactgca gacgccatca ccgcggaggg cttcaccgac      780

attgacctgg acacgctggt ggctgtcctg gagcgcgaca cactgggcat ccgtgaggtg      840

cggctgttca atgccgttgt ccgctggtcc gaggccgagt gtcagcggca gcagctgcag      900

gtgacgccag agaacaggcg gaaggttctg ggcaaggccc tgggcctcat tcgcttcccg      960

ctcatgacca tcgaggagtt cgctgcaggt cccgcacagt cgggcatcct ggtggaccgc     1020

gaggtggtca gcctcttcct gcacttcacc gtcaacccca agccacgagt ggagttcatt     1080

gaccggcccc gctgctgcct gcgtgggaag gagtgcagca tcaaccgctt ccagcaggtg     1140

gagagtcgct ggggctacag cgggaccagt gaccgcatca ggttctcagt caacaagcgc     1200

atcttcgtgg tgggatttgg gctgtatgga tccatccacg ggcccaccga ctaccaagtg     1260

aacatccaga ttattcacac cgatagcaac accgtcttgg gccagaacga cacgggcttc     1320

agctgcgacg gctcagccag caccttccgc gtcatgttca aggagccggt ggaggtgctg     1380

cccaacgtca actacacggc ctgtgccacg ctcaagggcc cagactccca ctacggcacc     1440

aaaggcctgc gcaaggtgac acacgagtcg cccaccacgg gcgccaagac ctgcttcacc     1500

ttttgctacg cggccgggaa caacaatggc acatccgtgg aggacggcca gatccccgag     1560

gtcatcttct acacctaggc tgcccgacac cgacaccgcc ctccctccgt ggggatagcc     1620

gcagccccag gccatcatct gctgctgggg cccccccacc acgcggtgcc aggcccagtg     1680

tcccccaggc cgtctgtcca ctccatgcca cctttctcag catcaggacg gggttgccct     1740

gtgttcacca cgagtgtggc tgctggatca gggcagccgg ggaggtggcc aggccagtgg     1800

ccaggccctg tggagacaat ccctcaggac tagggacagg gctgtgccgg cctgggccag     1860

ggcccacgga cccgcagctc agggcgcctg cccacgtcgt ctgccggcgg tgcgccgcgg     1920

gcgtccctcg cgtctcttca ctgcacattg caatgcattt gcgattccca tttctctgct     1980

aggagccagc ctgggtggcg ctgctcccag agccgtgggt cccagacctt gcgttccttt     2040

tgttcctgtc cgtttatcag gacacgggcc ccacctgtca cgtgcccgag gccacccaag     2100

cccagcctgc ggggcgttcc cactgcctgg atgccggctt gagttctgcg cacgcaggat     2160

tcagtgtggg gacggcccct gccggatagg cctagccctg gcccaggtgg tgagcggttt     2220

gcagtgtccg ttctcatcca cctgatgggc ccagataaag gcccccgctg tccagcctcc     2280

ctggacggcc ctcgcggtcc ctgcagccca agatgggact cagaccctgt gccccagagc     2340

tcccctgccg cagaatgggg ccccagccgg ccccgaccgg gtccaggagc actgctcgcc     2400

tgtacatact gttgccctag cccacctggt gccgtgggag ccacccccag gtgctggggg     2460

cacagcccct ccccactccg gccacgcccc cacccacccc gcgtgtttct gccctgtgac     2520

tcctggaacc tgcgtcctcc ccaaagccat gggaggggtg tcctcctcag accatgcccc     2580

cagatgattt ttttaaataa agaaacaaat gcacctgc                             2618


<210> 326
<211> 2276
<212> DNA
<213> Homo sapiens

<400> 326
ccgcggtgcg gccctggcgg ccgttgaaaa atggcgactg tggcagagtt gaaggctgtt       60

ttaaaggaca ccttggaaaa aaagggggta ttagggcatt taaaagcaag gatccgagct      120

gaagttttca atgccctaga tgatgaccgt gaaccccgac catcattgtc tcatgaaaac      180

cttctaatta atgaattaat tcgagagtat ttagaattca acaaatataa gtatacagca      240

tctgtcctca tagcagaatc tggtcaacct gtagttccgt tggacagaca gtttctcatc      300

catgaactaa atgcatttga agaatcaaag gataatacaa tacctctttt atatgggatt      360

ttagcccatt tcttgcgtgg aactaaggat ggcatccaga atgcatttct gaaagggcct      420

tcacttcagc cttcagaccc aagtcttggc agacaaccta gtagaagaaa gccaatggat      480

gaccacctaa gaaaggagga acagaaaagt actaacattg aagatcttca tgtttctcag      540

gcagtcaaca gataatgctt tgtttggggt atcttttgtc ttaaaattgt attattaatt      600

aaataactta tttattgtcc caatgttacc aaaatgcacc actaatgttt gtagaaattg      660

gagtttctac aaaacacccc tcatgtttaa ctacatttgt gaataaaagc taactcttgt      720

catctagctt attggatttg acttgaaaaa aaaagtattg tttttacgaa gtattttttg      780

tttttttgag atggagtctc gctctgtcac ccagactgga gtgcagtggc acgatctcgg      840

ctcactgcaa tctctgcctc ccggattcaa gtgattctcc tgcctcagcc tcccaagtag      900

ctgggaaaac aggcctgtgc caccacaccg gagtagtttt tgtattttta gtagagatgg      960

ggtttcacca tgctggccag gctggtcttg aactcctgac ctcaggtgat ctgtgtgccc     1020

cagcctccca aagcgctggg attacaggtg tgagccactg agcccagcca tttaggaagt     1080

attataaagg cccttaaagt ttgtaaggaa atgaaagggc tttgtattac cttttcaata     1140

ggcaacaatg tactttttct ttccttagac tttggcttac tggaagattt aattaaaagg     1200

tagaggagaa gtaaatttgc tgtaataatt ttgctgtaaa taaaacaaag agtttatttt     1260

attagataaa gaatgtgaag taagcatgaa gagacaggct ttgggagaaa taccagaaag     1320

ggatttttca aagatggcat tgtttaatct ccgtgtggcc ctcggttgtg caatcacaga     1380

tgagccagaa gagggccagc cccctacttg tttgggctcc gaaactctta ccaaacatca     1440

atttttattc ttgggataga aaaatagtat gtgctatctc taatacgcta cttcgatatt     1500

tattaaagaa gtatttttaa tgtagtgtcc acaggctcat ttcattgaaa acaactgact     1560

atgatgatag acagctcctg attggcaaaa gttcgatggt atattcagaa ttaaattttg     1620

cctgcacacc taaacactga caacatttag cttaaaggtt ttccatggag aagagtggta     1680

agagctgtag ttagcaaaat tggcatcctc tttagggtgt caattctgtg ctgctttgca     1740

aattgttgaa acttttgatt ttctgtttgg caatgctagt cagtgttcac ttcttacaga     1800

ttagccaaga atttttatct aaatgcagaa acttattaat gaaatccatt taaactatac     1860

ttacacaaca ttttgggagg ccctgctggt aaaattatat atggatgcag aagtattgca     1920

agagtccatt ttccattttt aaatctgcaa tatctgatta cattgatgaa ttccgttgta     1980

ttgtatgtgt gaatataaat atctgaattc tcccggggga cttggttttc gtccaaggat     2040

gttggcagtg gacacttagt ttacctcagg aattgcaatc atgtaagact atattcggaa     2100

aaaatgctgg agtatataat tttggatact gatataaaat catcaagatg gaagttaagc     2160

agaattgtca cgtgtagtcc atagcgcttt tatatgcatt attctgtaat ttgtttgtac     2220

tgcggcaact ttttatactt tcaatgtatc atttaataaa aaaaataagc aagtca         2276


<210> 327
<211> 2216
<212> DNA
<213> Homo sapiens

<400> 327
agcatccggg ctcccggcag cggcgctgcg gcggctcgcg ggagacgctg cgcgcggggc       60

tagcgggcgg cggagcggac ggcgacgggg cgctctcggg ctgccggcgg ggccgagcgc      120

cgcgcgtccc gagcatggca ggctccctgc ctccctgcgt ggtggactgt ggcaccgggt      180

ataccaagct tggctacgca ggcaacactg agccccagtt cattattcct tcatgtattg      240

ccatcagaga gtcagcaaag gtagttgacc aagctcaaag gagagtgttg aggggagttg      300

atgaccttga ctttttcata ggagatgaag ccatcgataa acctacatat gctacaaagt      360

ggccgatacg acatggaatc attgaagact gggatcttat ggaaaggttc atggagcaag      420

tggtttttaa atatcttcga gctgaacctg aggaccatta ttttttaatg acagaacctc      480

cactcaatac accagaaaac agagagtatc ttgcagaaat tatgtttgaa tcatttaacg      540

taccaggact ctacattgca gttcaggcag tgctggcctt ggcggcatct tggacatctc      600

gacaagtggg tgaacgtacg ttaacgggga tagtcattga cagcggagat ggagtcaccc      660

atgttatccc agtggcagaa ggttatgtaa ttggaagctg catcaaacac atcccgattg      720

caggtagaga tattacgtat ttcattcaac agctgctaag ggagagggag gtgggaatcc      780

ctcctgagca gtcactggag accgcaaaag ccattaagga gaaatactgt tacatttgcc      840

ccgatatagt caaggaattt gccaagtatg atgtggatcc ccggaagtgg atcaaacagt      900

acacgggtat caatgcgatc aaccagaaga agtttgttat agacgttggt tacgaaagat      960

tcctgggacc tgaaatattc tttcacccgg agtttgccaa cccagacttt atggagtcca     1020

tctcagatgt tgttgatgaa gtaatacaga actgccccat cgatgtgcgg cgcccgctgt     1080

ataagaatgt cgtactctca ggaggctcca ccatgttcag ggatttcgga cgccgactgc     1140

agagggattt gaagagagtg gtggatgcta ggctgaggct cagcgaggag ctcagcggcg     1200

ggaggatcaa gccgaagcct gtggaggtcc aggtggtcac gcatcacatg cagcgctacg     1260

ccgtgtggtt cggaggctcc atgctggcct cgactcccga gttctttcag gtctgccaca     1320

ccaagaagga ctatgaagag tacgggccca gcatctgccg ccacaacccc gtctttggag     1380

tcatgtccta gtgtctgcct gaacgcgtcg ttcgatggtg tcacgttggg gaacaagtgt     1440

ccttcagaac ccagagaagg ccgccgttct gtaaatagcg acgtcggtgt tgctgcccag     1500

cagcgtgctt gcattgccgg tgcatgaggc gcggcgcggg cccttcagta aaagccattt     1560

atccgtgtgc cgaccgctgt ctgccagcct cctccttctc ccgccctcct caccctcgct     1620

ctccctcctc ctcctcctcc gagctgctag ctgacaaata caattctgaa ggaatccaaa     1680

tgtgactttg aaaattgtta gagaaaacaa cattagaaaa tggcgcaaaa tcgttaggtc     1740

ccaggagaga atgtgggggc gcaaaccctt ttcctcccag cctatttttg taaataaaat     1800

gtttaaactt gaaatacaaa tcgatgttta tatttcctat cattttgtat tttatggtat     1860

ttggtacaac tggctgatac taagcacgaa tagatattga tgttatggag tgctgtaatc     1920

caaagttttt aattgtgagg catgttctga tatgtttata ggcaaacaaa taaaacagca     1980

aacttttttg ccacatgttt gctagaaaat gattatactt tattggagtg acatgaagtt     2040

tgaacactaa acagtaatgt atgagaatta ctacagatac atgtatcttt tagttttttt     2100

tgtttgaact ttctggagct gttttataga agatgatggt ttgttgtcgg tgagtgttgg     2160

atgaaatact tccttgcacc attgtaataa aagctgttag aatatttgta aatatc         2216


<210> 328
<211> 1735
<212> DNA
<213> Homo sapiens

<400> 328
gtgcgcgggg gcccgaccac cgcggggccg ggacgcgatg gcggcggcag agcccgcgag       60

ctcgggccag caggcgccgg cagggcaggg gcagggccag cggccgccgc cgcagcctcc      120

gcaggcgcaa gccccgcagc cgcccccgcc gccgcagctc gggggcgccg ggggcggcag      180

cagcaggcac gagaagagcc tggggctgct cactaccaag ttcgtgtcgc tgctgcagga      240

ggccaaggac ggcgttctgg atctcaaagc ggctgctgat actttggctg tgaggcaaaa      300

aaggagaatt tatgatatca ccaatgtctt agagggaatt gacttgattg aaaaaaagtc      360

aaaaaacagt atccagtgga aaggtgtagg tgctggctgt aatactaaag aagtcataga      420

tagattaaga tatcttaaag ctgaaattga agatctagaa ctgaaggaaa gagaacttga      480

tcagcagaag ttgtggctac agcaaagcat caaaaatgtg atggacgatt ccattaataa      540

tagaacattt tcctatgtaa ctcatgaaga catctgtaat tgctttaatg gtgatacact      600

tttggccatt caggcacctt ctggtacaca actggaggta cccattccag aaatgggtca      660

gaatggacaa aagaaatacc agatcaatct aaagagtcat tcaggaccta tccatgtgct      720

gcttataaat aaagagtcga gttcatctaa gcccgtggtt tttcctgttc ccccacctga      780

tgacctcaca cagccttcct cccagtcctt gactccagtg actccacaga aatccagcat      840

ggcaactcaa aatctgcctg agcaacatgt ctctgaaaga agccaggctc tgcagcagac      900

atcagctaca gatatatctt cagcaggatc tattagtgga gatatcattg atgagttaat      960

gtcttctgac gtgtttcctc tcttaaggct ttctcctacc ccggcagatg actacaactt     1020

taatttagat gataacgaag gagtttgtga tctgtttgat gtccagatac taaattatta     1080

gattccatgg aaacttggga ctgttatcta cctctaactg tgtaacattt tagacttctt     1140

aataacctaa atatttaaaa taatgaatgt aacacctttt ttagttcact gattctgaag     1200

tgttcttccc taatactttc tttacttcac aaaacttcaa ccataaaaac aaagggctct     1260

gattgcttta ggggataagt gatttaatat ccacaaacgt ccccactccc aaaagtaact     1320

atattctgga tttcaacttt tcttctaatt gtgaatcctt ctgttttttc ttcttaagga     1380

ggaaagttaa aggacactac aggtcatcaa aaacaagttg gccaaggact cattacttgt     1440

cttatatttt tactgccact aaactgcctg tatttctgta tgtccttcta tccaaacaga     1500

cgttcactgc cacttgtaaa gtgaaggatg taaacgagga tatataactg tttcagtgaa     1560

cagattttgt gaagtgcctt ctgttttagc actttaagtt tatcacattt tgttgacttc     1620

tgacattcca ctttcctagg ttataggaaa gatctgttta tgtagtttgt ttttaaaatg     1680

tgccaatgcc tgtacattaa caagattttt aaaaataaaa ttgtataaaa cattc          1735


<210> 329
<211> 1829
<212> DNA
<213> Homo sapiens

<400> 329
agttaattct gtctgggagg agtgtgtgtg tttaagacag tgcctgggat gacttataat       60

gtaatcttta ggcaaaacgc tttgtaattg gtgcagctct gagaacacac gcatgcattc      120

caggcggtgc tgctggggct cggcggggcc gtgtctggtc tgcaaggcgc gcgggctcgt      180

ggggggttgg ctggggagcc cacgctgcct ggcgactcgg gccaccgaat gtgagaccga      240

gtccctttat gtcaccagcg cacacgctga tttgaaccct gcttcgacgt gtgtgtcatg      300

gcttaaaaat agctgctaat ctgtcaacct gtcttgggca gaaacagcgg cggcgacagc      360

agcaggagcg tcatggccgt ggcgctgtct gcgccggcga tccgcctttc ggactgaggc      420

ccagcgcagc gcttgcaaag agcagcagct acctggcaac tgaacccatc atcaccacag      480

ccactcctgc agctgccacg gtttctgcca cctctaagat gtgccctggt aactggcttt      540

gggcttctat gacttttatg gcccgcttct cccggagtag ctcaaggtct cctgttcgaa      600

ctcgagggac cctggaggag atgccaaccg ttcaacatcc tttcctcaat gtcttcgagt      660

tggagcggct cctctacaca ggcaagacag cctgtaacca tgccgacgag gtctggccag      720

gcctctatct cggagaccag gacatggcta acaaccgccg ggagcttcgc cgcctgggca      780

tcacgcacgt cctcaatgcc tcacacagcc ggtggcgagg cacgcccgag gcctatgagg      840

ggctgggcat ccgctacctg ggtgttgagg cccacgactc gccagccttt gacatgagca      900

tccacttcca gacggctgcc gacttcatcc accgggcgct gagccagcca ggagggaaga      960

tcctggtgca ttgtgctgtg ggcgtgagcc gatccgccac cctggtactg gcctacctca     1020

tgctgtacca ccaccttacc ctcgtggagg ccatcaagaa agtcaaagac caccgaggca     1080

tcatccccaa ccggggcttc ctgaggcagc tcctggccct ggaccgcagg ctgcggcagg     1140

gtctggaagc atgaggggag ggggagagag gtcaggccag gcccgtgggt aggtccctgg     1200

ctcccagctg gagataggag gcccaggtgg caggtagcag gaggcccaga tcacccatcc     1260

tcccctgggg tcaggagagg ccgagcccca ggccactgtc actctttgtg ggaggggacg     1320

gggagtgagg ttgggcagtg tggtggatgg gcacccagga agggttgacc agggaaggag     1380

gcagctaggc tgtagatgga agatggtcct gggattcgaa caccgctggg atctggccag     1440

ggtgctccct gggattcaca gtcccttccc ctctttgtgc ccaagtgttt ccctctctcc     1500

ctcaccaaaa caaaagggcc atctctgccc tgcacttgtg cagaaagtca gggatacggc     1560

aagcatgaat gcaatggtgt agagttgtgt gaaaccccta gcatagagac agacagcgaa     1620

gagatggtgt gaaaagcttg cagaaccaga cagagaaccc cacagacttt ccactccaag     1680

cacaggagga ggtagctagc gtgtgagggt tggcactagg cccacggctg ctgcttgggc     1740

caaaaacata cagaggtgca tggctggcag tcttgaaatt gtcactcgct tactggatcc     1800

aagcgtctcg aggataaata aagatcatg                                       1829


<210> 330
<211> 4485
<212> DNA
<213> Homo sapiens

<400> 330
gcgcaatacg cggcacgcgc caggccaaag actaggagcg aagcgtgcac gccttgtctt       60

tctccacctt tcgtctttgg tcacagcgcc atctcatggt tagctgaaac tttgaaagag      120

gattcattct tcagaggcaa ggaatcggag tcctatgtct ttctcgcgcc ttgaaggtta      180

cttagctaaa gctaagatag cgagaaacag tacttttcag gtccttccat gatctacatt      240

cgtccttgtt ctcggaggac ccagactcta tggttaatga tgaagagggg cctctattcg      300

ttcagcgctt gcgcatgcga ggaggttccg catgcgcggt ggagtgagcg aagcgcacgc      360

tgaggaggat cggcggccgg tgagggggaa gcaagtctgg tctctgtgat tgaagaagtc      420

ggctctgggc tccagtgcgg gaatcacaca catacctcag aatgccgggt ctaagttgta      480

gattttatca acacaaattt cctgaggtgg aagatgtagt gatggtgaat gtcagatcca      540

ttgctgaaat gggggcttat gtcagcttgc tggaatacaa caacattgaa ggcatgattc      600

ttcttagtga attatccaga aggcgtatcc gttctatcaa caaactcatc cgaattggca      660

ggaatgagtg tgtggttgtc attagggtgg acaaagaaaa aggatatatt gatttgtcaa      720

aaagaagagt ttctccagag gaagcaatca aatgtgaaga caaattcaca aaatccaaaa      780

ctgtttatag cattcttcgt catgttgctg aggtgttaga atacaccaag gatgagcagc      840

tggaaagcct attccagagg actgcctggg tctttgatga caagtacaag agacctggat      900

atggtgccta tgatgcattt aagcatgcag tctcagaccc atctattttg gatagtttag      960

atttgaatga agatgaacgg gaagtactca ttaataatat taataggcgc ttgaccccac     1020

aggctgtcaa aattcgagca gatattgaag tggcttgtta tggttatgaa ggcattgatg     1080

ctgtaaaaga agccctaaga gcaggtttga attgttctac agaaaacatg cccattaaga     1140

ttaatctaat agctcctcct cggtatgtaa tgactacgac aaccctggag agaacagaag     1200

gcctttctgt cctcagtcaa gctatggctg ttatcaaaga gaagattgag gaaaagaggg     1260

gtgtgttcaa tgttcaaatg gagcccaaag tggtcacaga tacagatgag actgaacttg     1320

cgaggcagat ggagaggctt gaaagagaaa atgccgaagt ggatggagat gatgatgcag     1380

aagaaatgga agccaaagct gaagattaac tttgtgggaa acagagtcca atttaaggaa     1440

cacagagcag cgcttcctgg ctgtaaatcc tagacttgaa agttttccag tattgaaaac     1500

ttcaaagctg aatatttttt atttctaagt atttaaatgt tctaacagat cagaacatga     1560

aatgccctcc taaatgtcag ctgttgtcac acagtagctc caacactttg agcattttta     1620

agggagtggc ctcatttcac tagagacaaa tctttaagaa tagttctaaa attgggcttg     1680

tgatttccat ttctgatgtc tccagattgg cacccctttc tagttcaatg cctcacgaga     1740

tttgccaggg gcatccaagg caaacaatcc caatctttct atataaaatg tattcaagca     1800

aacatcaaat aaatttctgg gatatttaac tataggcttc ttccttcttg tcaccagtta     1860

aaagcatttt aatactaaga ccctaattct tttatcttta ttttagtctt gatgtggaac     1920

tgtaggagca ggtgaataaa ggatctctat aacagatcct ttcaaaagaa gagttttaga     1980

gaaaataaat ttaactttaa ccacagtgaa agttgaccct tagcgggaca aagccttaaa     2040

atgcattgaa agaattagat cggttctgtg ccttttatct atttgagatt gatgacaacc     2100

tgtgtgagag aatttatcac accacgtcct tattggaata ataagctact tgccttgagt     2160

ttataattca gggtggtaaa gtatgttttt aaattttaaa aagcagctgc attttttatt     2220

tagttggaat atcacccaat tttttatttt tattgctatt aaaatatcca ctagatgcca     2280

cctagagctc cagttcttta taacaaaaca gggatctgtt tgaacactta ctgttgtttt     2340

ttttttttta catgtttcca tcatttctgt ctttaagaac taattcgtac ataataagtt     2400

tcataggtaa cacattattt gaagttacag ctacagtagt caggtgtaga aaatcttgag     2460

ttgctttggt ctgcttgtct tcataaattt attctcttat gatacttgag gtaccagttg     2520

tatttaattt tattcattat ccctagatag ctattaagat acttagatta gacctaaccc     2580

accatagtca atccaagact agactactca atattaaagg gtctggaaaa tagaagagtg     2640

tgttgggcag gtagtttgta ccatttatga aggtttgttc ctttgttaaa tttagcagcc     2700

tgtactagct tttgaaatcc agaagtttta acttccagtg gctggtttct gagagagtgc     2760

catgattgct agccagcatt ccatattggg aatatgtaga ggagaacctg gatgtactta     2820

agagtggcat ataattttca cttctgtctg ttgaggcatc aaaaaaacaa gtttagaaag     2880

ctggcaacat gaagaatgca ttcaaaatat aacaggtgct tctttgttgt acgcagagga     2940

attttttctt ttgattttgt ttactgaaat ttgttatact tcaaaagcca taacttgaaa     3000

aatactggtg gcgtcgatgg tgagtgattt ttatcccacg tgggcctttt gctcagttcc     3060

atggcaattt tgtaaattga ccctagccag agaatagatc agtatttcac tgataccacg     3120

aggaaaagaa caaacaaaac ttaaaagtat tcatacacct tgctaaccta aaagacagca     3180

gggacaagat acatatgagg acaaggtata cacccagttc tgaataactt gaagaacagg     3240

cttggcaaag aagtaagttt atccaaatct tgaatttctg ccaggcatgg tagctcatgc     3300

ctgtaaccct ggcacttaag gggccaaggc aggaggatca cttgaggcca gtgagctgtg     3360

atcactccag tgcactcgag cctgggtgac agggcaagac cctgtctcaa aaaaaaaaaa     3420

aaaaaccaaa aatcttgaat ctcccatcaa agccttttca ttaaaaatac aatttcatct     3480

actccctact gtacctttca ctgatgtcaa gtggctatca attcatatag ctgaaaatta     3540

gtgatagttt gggtctcatt tatgcataaa ttaattgaaa atcagtaatg gccaggaaga     3600

aatatgaata ttcaaaccac ttttttcttt tttttttttt ttttttggca aatggtgtta     3660

tattgcctgg gcaggtctcg aaatcctggg ctcaagctat cctcctgcct ctgcctctgt     3720

aagagtgtga gccaccatgc cccacccaaa ccatttttca tatcagttat agcaaaacaa     3780

gacaaaccag ttcttaataa tgttcaaagt tggacccata gagacatgct aagcactaca     3840

tcatgctaag aagaacagtt attactcagc tgccatactt cagccattct acttttacac     3900

caagaacaaa atggctagag atttttttaa aaatacaaat gccagtacct tgccgagact     3960

tgttcactga tttgccccaa ccccaaggta atggtcatct actttgcaac ctatggagat     4020

cctgatagct cccatacaaa gtgaggtaca ctgttgccaa tttggaggca ggaagccatc     4080

aaactaaacg tagtttaatt cagatgaaca cctatcgata ttcaaaaggc aaaacaaaaa     4140

aactaattcc agggacatta gaccttggtg aaatgccaaa tggaaaatgg tgctttaaaa     4200

ggtagtctct taccatataa ggaataagta aaacattagc ttgtgatttc tcattattca     4260

ggtcaatgtt ttagacacga ctaacaaggg acagttcaaa ctattaaaga gaacaaattt     4320

ttacttaagc actttgaggt atccactccc cttaaatgta agttatgtat tttatctgtt     4380

gattaagggg aggtccaagc atttgtactt ggcaggaatg ctggcaatag cttgtgccag     4440

attactgtat aaacttgaaa gtaataaaaa tgttctttaa aagta                     4485


<210> 331
<211> 856
<212> DNA
<213> Homo sapiens

<400> 331
ggcggcggcc atggcgggac aggaggatcc ggtgcagcgg gagattcacc aggactgggc       60

taaccgggag tacattgaga taatcaccag cagcatcaag aaaatcgcag actttctcaa      120

ctcgttcgat atgtcttgtc gttcaagact tgcaacacta aacgagaaat tgacagccct      180

tgaacggaga atagagtaca ttgaagctcg ggtgacaaaa ggtgagacac tcagaacagt      240

gccgtgctgc tgctgggaag ttgctttaca caacacaggc cacatgggaa aggccccagc      300

agccttcagc tccttccttt ctccttaaag agcaacaggg cttattcttg tttttctttt      360

ttcaaaagtg tggcctttgg gctctgccat ctggggtgtg gtgtggtatg tgggaagaag      420

ttcagaggaa ccgttggaaa cgacgttagg cattttacct tttcagtaac attttataca      480

tctacttgtc aatgtatttg agacattcac agccaaaagc ctgggactct ttgtgaaggt      540

cctcctcacc tctatctttc tttctctctc tctcaaactt tccttaaagt tctcattgcc      600

tttgcactgc ttctgtgaac agtctttgtc tcctccccac ctttggtggg aagtgcgggg      660

cagtcctggt caagacactc atgccctggc aatgtggctg ccagagaatg ttgttgctaa      720

cccaccagtt tcttgttgat ttggagaggt caaggccagg cccccacttg gcttgaaggg      780

acattttcag acttttcttt ctgtcacttg gagtgtctat gcctctcata tttccctaat      840

aaactcctca actttt                                                      856


<210> 332
<211> 5005
<212> DNA
<213> Homo sapiens

<400> 332
atggcggcgg cggcggcggc cgccaccacg gccgcctgca gcagcggcag cgccggcacc       60

gacgccgcgg gcgccagcgg attgcagcag ccgccgccgc agccccagcc tcagcccgcg      120

gccgccgcgc cggcccagcc gccgcccgaa cccccccgga agccgcgcat ggacccgcgg      180

cgccgccagg ctgccctctc cttcctcacc aacatctcgc tggacggccg gctgccgccg      240

caggacgcgg agtggggcgg tggcgaggag ggcggcgcgg ccaagccggg cgccggcggc      300

gcctgcggcg cgaggactcg gttcagcttg ctcgccgctg ccgagcgggg cggctgcatc      360

gcgctcgccg cgccgggcac gccggctgcg gggttagccg ctgggtccgg cccctgcctc      420

ccacagccct cgtcgctgcc gcccttgatt cctggcggcc atgcgaccgt gtccggcccc      480

ggggtggcgc gggggttcgc gagtcccctg ggcgccggcc gggcgtcggg ggagcagtgg      540

cagccgcccc ggccggcgcc tctcgccgcc tgtgcccaac tgcagctgct cgacgggtcc      600

ggggccgccg ggcaggagga gttggaggag gacgatgcct ttatcagcgt gcaggtgccg      660

gcggccgcct ttttgggctc cgggaccccc gggagtggga gcggcagtcg gggacgcctc      720

aactcgttca ctcagggaat cctgcccatc gccttctcca ggccgacttc gcagaactac      780

tgctccctgg agcagccagg ccagggcggc agcaccagcg ccttcgagca gctgcagagg      840

tcccgacggc gcctcatctc ccagagatct tccttggaga ccctggaaga tattgaggag      900

aacgcccctc tccggagatg tcgaactctc tcaggttcac ccagaccaaa gaattttaag      960

aagattcatt ttatcaagaa catgcggcaa cacgatacca ggaatggcag aatagtcctt     1020

atcagtggca gaagatcctt ctgtagtata ttttcagtgc tgccgtatcg cgacagtacc     1080

caagtcgggg acttgaagtt ggacggagga agacaatcaa ctggtgcagt gagtttgaaa     1140

gagatcattg gtctggaagg tgtggagctg ggtgctgatg ggaagactgt ttcctatacc     1200

caatttctgt tacccacaaa tgcctttgga gcccggagaa ataccataga ctccacctcc     1260

tctttctccc agttccgtaa cctgagccac cgcagcctct ccataggccg ggcaagcggc     1320

acccagggga gcctcgacac aggtagtgac ctgggagact ttatggacta tgacccaaat     1380

ctcttggatg acccccagtg gccttgtggc aaacacaaac gcgttctgat cttcccttcc     1440

tacatgacaa cagtgattga ctacgtgaag ccctcggatc tcaagaagga catgaacgag     1500

accttcaagg agaagtttcc tcacattaag ctgacactca gcaaaattag gagtctgaaa     1560

cgagagatgc ggaagcttgc gcaggaggac tgtggccttg aggagcccac ggtggccatg     1620

gccttcgtct actttgaaaa gctcgccctc aaggggaaac tcaacaaaca gaaccggaag     1680

ctgtgtgctg gggcatgtgt gctgttagca gccaaaattg gaagtgacct caaaaaacac     1740

gaagtcaagc atttaattga caaactggaa gagaagttcc ggctgaacag gcgagaactg     1800

attgcctttg aattcccggt gttagtggcc ttggaattcg ccctccactt gcccgagcac     1860

gaagtcatgc cccactacag acggctggtc cagagttcct agcactggcc ccgaggacag     1920

ccaagggcca tttcttctca gcttggtgga gcagcactta cttactactg gaaatgaaaa     1980

aaagtagaac tcagaatacc agacttttct tcctctcgac atagtttggg gagaagcagt     2040

actagaaact ttccaaggag tcttgggtgt gtagccaaga ggagccatga gctatggact     2100

cctcaagcac gggaagagga ggtgtgtgct gagaacagag aggccctgcc ctctgtccac     2160

tagcgagaat ccctagctgc cccagcccag tctttctccc cggcattcac aaactttgca     2220

agcgtggtcc agggccttct ccagatctgt tccaacttgg agtgtgaagg gcttgagcat     2280

acgggggaag agagtctgca gaagttgggg gaaaactttt aaaagatacc ctcattgtgt     2340

caaagagtgt gccaatctat ttttgtatca gcattggaag tgcactttcc cctggggcgt     2400

gtgggtgtgt gaatgtgcaa gtgtctgaga gatactgcat cagccctaga cccccagagc     2460

cagtcccgcc ctttacagag cagcccttag cctggggcca tgggtcaggc tgaccttcaa     2520

caattatttc tagatgattt ctggataaga attgctctct cggtaccaga cagtttgaca     2580

tcctccaccc ttagaaaatg actgacattg ttttgttact gctcctaccc accaagggga     2640

taaagaaggc gagttctgag tgttggatga gtcagtcgcg tggaaggacg tggagcgtgg     2700

cgctctgtaa cttcctgccg tctgccaccc cgccacgtgt atttaaccct cgcactttct     2760

ccactgtgga gatggctggg gcggcgcccc acagtgtgta ttcctgtcct ctatgttaga     2820

gtgcatcaga agcacattta ctgtgctatc tatatcgcta tataaaagtg ttttataaaa     2880

acccagaata ggagcacgac gcatgattgg tgtttgaggc gtttgccagc tgggacaaac     2940

tgcgtttgga gctgtggtta agctgactaa ggaggcggtg gctctttctt aacattccca     3000

cgtgcccagg gctgttcatg caagatttta atggtgactt gtcctggctt actgggacag     3060

tctgtatgag gcatgtcacc acactgtcgc ctcatagctg caagagagag gcaccagctg     3120

aagttcccct gactgaagag agcctgtggc catgtaaaaa gagaattaaa ctcttgttgc     3180

tttttgtata cctgtatgcg tttgtgtaga cgtgtgtctc accagtcacc tttgccctgc     3240

attgctgatc cccttgcgca cactgattct agtgaggtca cagattcgga gcttcacaca     3300

ccagcccaga gaaagggcga tggaaccgaa ccgagggtct gcagctttcg ttagcagagc     3360

tgtcagattc ttgacagtct tggaggatgg agaaattcaa gcagcagctg gtgagggcca     3420

aaacagaata cttggcttct tcagaatctt agattgcact gagtttagtc ctaaatattt     3480

tgctaacaaa tttccttggc cagaatcagt tgtaagacag tgatttgggt ggtgggggga     3540

gggaggaggg agaggatatg attaatgtgg tctctttggc tgatcgaaag ctagatcaac     3600

tggtacttag ggcacttgct gtttataaag caaaattgag aaaatattca aggtgcctcc     3660

atcgcctgaa ctacaaaatg cccttggcct tcctcacatg gggtctgtca ccttgcatct     3720

ctgataagcc atccaccttc ctggtcagtg cctacagggg gagagccttt ctgagaagca     3780

ggtcctgtgg tatctgagaa tggtctagag agctccccac tgcccatctg cccccgaatt     3840

tcctgccaag ctctggggag tggggtgggg ggagggacgt ccgatggatg acaggccgcc     3900

agcccagacg tggggagaga agcctgagtc ctttcctgtg tgataaaatc aggctaattt     3960

acttggattt ggggtgattt gtttggtttt tagcatttat gaggtgagcc catgaagtta     4020

gtggtccatt actttttaaa gatgcatttt cattttaaac tgtctcctgg cctgtggatt     4080

tgtggaatgg acagttttgt gggttttaat ttatttgtga ggagtcgggg ctgagaaggc     4140

attttatcag gaggtctcct tttgcacgtc catgacatga gcttttcgga ggcaaaggaa     4200

gtggaggagg gtgagagatg caggtcactg ccagaggcac ctctgtgaca cggaacattc     4260

cagacacgtc gcagccttgg gcttcggcga ggaggaagtc tgagcctgtg aagcgagaag     4320

gccaggcagt agactggctc tgaggttttg ccctttgacc tcctccacag agggcagctt     4380

cagccccttg taagccctgc cccctctcag gactgccctg aggcctctcc agtcctcccc     4440

acactcagag atctgtgggg aagctccgcc cagccacact ccttgggata atactagccg     4500

gttctgcctg attccttttc ccccggagcc agcctagggg gcccgggact cctctagtga     4560

gccttgactg ttaggtaaga gacaggaagc agacaagcca agaggttgct gcagctgccc     4620

ccaggaggaa acgggcagca gggagtgtgg cccagccccc actgtacccc tccaggggcc     4680

cgagcccttg ccagcccaat gacaccttga agtcaccact tttcctttct tgcccgctaa     4740

taaaacctat ttaaacagga aattcatacc aaatgcaaat gggttttgtt ttccttggca     4800

ttttgttgtt ccgatcacag atttccctgc cagggtgtct gtggttatca gctgcaggct     4860

cagcttgggg cggccgcttc acacaagcca ctctgtacca cgtgccctac cttagtgacg     4920

ggagtaagga gcttccttcc cctccatgtc attccttcct gttcccttca ttccccaaca     4980

gcaaataaaa ctgttgaatg ctctg                                           5005


<210> 333
<211> 4570
<212> DNA
<213> Homo sapiens

<400> 333
gacggaagga gctagtgggg gactcgaggc ctgagggcaa tgcggctgga ggcggaggca       60

acggcggctg gagctgccgg actttaattt ttggaagtga ataaaacttg ttttagaaga      120

cgagatgact acagctgtag agagaaagta tattaatatt aggaaaaggc tggatcagct      180

gggataccgc cagactctga cagtggagtg tttacctttg gtagaaaaac ttttcagcga      240

cttagttcat acaactgaga gccttcggca atcaaaatta tctgctgtga aagctgaaaa      300

agaaagtgcc aattttgatt ttgttttgga accctataaa cttgaaaatg caagattgag      360

tagagaaaat aatgaattat acctagagtt aatgaaactg agagaacatt cagaccaaca      420

cgttaaagag ttgaaaactt cattgaagaa atgtgcacgt gaaacagctg atctgaaatt      480

tctgaataac caatatgctc ataaactcaa actgttggag aaagagagca aagctaagaa      540

tgaaagaatt caacaacttc aagaaaagaa tttgcatgct gtagtacaaa ctccaggtgg      600

caagaaaaga agtattgctt tcaggcgcca gcgtatgcaa attgatgaac cggttcctcc      660

ctctgaagtc agttcatatc cagttcctca accagatgac ccttacattg cagacctcct      720

tcaagtggct gataacagga ttcaagaact tcaacaggaa gtccaccagc tacaagaaaa      780

gttagcaatg atggaaagtg gggtgagaga ctatagcaag cagattgagc taagagaacg      840

agagatagaa cgactgtcag ttgctttgga tggtggtcgg tcccctgatg tcctttctct      900

ggagtctaga aataaaacca atgaaaagct tattgctcat ttaaatattc aggttgactt      960

tcttcagcaa gctaataaag acctggagaa gcgtatacga gagcttatgg aaaccaagga     1020

aacagtgaca tctgaagtcg ttaatttaag taacaaaaat gaaaaactct gccaagaatt     1080

aactgaaata gatcagttag cacagcagtt ggaaagacat aaagaagaag tgcttgagac     1140

tgctgataaa gagcttgggg aagcaaagaa agagattaaa agaaagctct ctgaaatgca     1200

ggatcttgaa gaaacaatgg caaaacttca gctggaattg aacttatgcc agaaagaaaa     1260

ggagagactg agtgatgaac tccttgtaaa atcagaccta gaaactgttg ttcatcagct     1320

tgaacaagaa aagcaaagac ttagcaaaaa agttgaaagt tttgcagtta cagaacgaca     1380

acttactctg gaggttgaga ggatgagact agaacatgga ataaaacgtc gagacaggtc     1440

accttctcgt ttagatacat ttctgaaagg tatagaagaa gaacgagatt attataagaa     1500

agagctagag agactccaac atataataca gcgaagatct tgctctacaa gttatagcgc     1560

acgtgaaaaa agttcaatat ttagaacacc agaaaagggt gattacaatt cagaaattca     1620

tcagatcaca agagaaagag atgaacttca gcgtatgcta gaaagatttg aaaaatatat     1680

ggaagatata cagtccaatg ttaaattatt gacagcagaa agagataaac taagtgtctt     1740

atataatgaa gctcaggaag aattatctgc cctaagaaag gaatccaccc aaaccacagc     1800

accccataat attgttagtc ttatggaaaa ggaaaaagaa cttgcgttat ctgacttaag     1860

aagaattatg gcagaaaagg aagctttaag agaaaaatta gagcatattg aagaagtgag     1920

tctttttgga aaatcagaat tagagaaaac tattgaacat ttgacatgtg ttaatcatca     1980

gcttgaaagc gaaaaatatg aattaaagtc taaagtgtta ataatgaaag aaacaataga     2040

gtcgttagag aacaaattaa aagtccaagc tcaaaaattt agccatgtgg ctggtgactc     2100

atctcatcag aaaacagagg tgaactcact taggatagtg aatgagcagc tacagcggtc     2160

agttgatgac tatcagcacc gactttccat aaaaagaggt gaacttgaat cagcccaagc     2220

acaaattaaa atactggagg aaaagataga tgaactaaac cttaagatga cttcacagga     2280

tgaggaggct catgtaatga aaaagaccat tggtgttatt gataaagaaa aagactttct     2340

ccaggagact gtagatgaga agacagaaaa gattgcaaat ttgcaagaaa acctagctaa     2400

taaagaaaaa gctgttgctc aaatgaagat aatgatctca gagtgtgaat catctgtgaa     2460

ccagctgaaa gaaacattgg ttaatcgaga tcgtgagata aacagcctcc ggcgccagct     2520

tgatgcagct cacaaagaac tcgatgaagt aggaagatct agagaaatcg cttttaagga     2580

aaacagaaga ctgcaagatg acctggctac aatggcaaga gaaaatcaag aaatctcatt     2640

ggaattggaa gcagcagtgc aagaaaaaga agaaatgaag agcagagttc ataaatacat     2700

aacagaggtg tcacgatggg agagcttaat ggctgccaag gaaaaagaaa atcaagattt     2760

gttagataga tttcagatgc ttcataaccg tgctgaagac tgggaggtca aagcccatca     2820

agctgaggga gaaagcagct cagttcgact ggaacttctt tctattgaca ctgagaggag     2880

acatcttcga gaaagagtgg agctattaga aaaagaaatt caagagcaca taaatgccca     2940

tcatgcttat gaatctcaga tctcatcaat ggcaaaagcc atgtctcgat tagaagaaga     3000

gctgagacat caagaagatg agaaagcaac agtattaaat gacttgtcat ctcttagaga     3060

actttgcatt aaacttgatt caggcaaaga tattatgacc cagcaattga attcgaaaaa     3120

ccttgagttt gagagggttg tggtggaatt agaaaatgta aagtcagagt cagacctact     3180

gaaaaaacaa ctttcaaatg agagacatac agttaaaaac ctcgaatcat tgttggctac     3240

aaacagagat aaagaatttc attctcactt aacctcccac gagaaggata cagaaatcca     3300

gctacttaag gagaagttaa ccctttctga aagcaaatta actagtcaaa gccgggaaaa     3360

caccatgctt cgagctaaag tggcacagtt acaaacagat tatgatgctc tgaaaaggca     3420

gatctcaact gaaagatacg aacgagaacg agcaatccaa gagatgcgtc gacatggtct     3480

tgctacacca ccccttagtt ccactctgag gtctccttca cattctcctg aacatagaaa     3540

tgtgtaatta tcagaaagaa taatggcttt caatgagttc ctatgtggat ttttaaaaga     3600

acagaacagt aatgaaatat ttgaagtact tgttgctgaa aatcatgaac atggacacaa     3660

attctacctc tgtcaacttt tatttaaatc agtgaatatg ttaaaaagtt tggtttaaaa     3720

gaactatatc tatatgtata ttttcatata tatgacagaa caagaatatg tattaatagt     3780

gcctaatgta tctatatttt tattattcat gaattaaatt actaaaagta tgtttatact     3840

gtgaattaat ataatgtatt cacattattc tttaataatc tgtttattaa taagccatga     3900

tatgtgtatg taaatattct tacagtactt gtttttagtt gtcatgccta tgtttagacc     3960

atatcttaat gtattcacaa agaattatca actttgatgc tatgctgtca tgcttaactt     4020

tttcttctta aaattattca tagatctact gtctgttgtc aaggggaata tattcaggtc     4080

tagtcttctt ataatagcag aggtcttggt aaaataacta ccatatataa cgtgttattg     4140

ccatctagaa gaactatgat gagaaagata catttatata ttatgtaaaa tgttaactat     4200

catcatatgg actctatgta acacaaattc aaaagcaaac taaaagctat atgcagagtt     4260

ttgtataaaa caatagaaca gaaatttggg acatttttct aggaaataaa attcctcggt     4320

gtattaatct aaggtttcaa agtataaaag tatatggggt aggccgggtg cagtggctca     4380

cgcctgtaat cccagcactt tgggaggccg aggcgagtgg atttcctaag gtcaggagtt     4440

tgagaccagc ctgagcaatg tggtgaaacc ccatctctac taaaaataca aaaattatct     4500

gggcttggtg gcgggcacct gtaatcccag ccacttggga ggctgaggca ggagaattgc     4560

ttgaacccgg                                                            4570


<210> 334
<211> 3857
<212> DNA
<213> Homo sapiens

<400> 334
agtaacgcct tctccaagtg gatggcgggg tggacacgcg tcccggcgcc ccgggctccc       60

tgggatatgt agttcgcgac aggacgagcg gaaatactgc caggatttta ccacctctcg      120

cccatttatt tacttctcgg tcaccgcttt cgggggacag ataaacacca cagatgccca      180

tcaaaggggc gcacgggtct ggaggcgcag ctcaggtttt tgcgttggtc accctgccct      240

ccgcacgtgg agagggcagg cataaagcac cttgaaagga aggtgctgtc aatgctatcc      300

gacgacctgt cgccgggcac cgcagcatcc tcgctcgctc cgatgggacg agggacgccg      360

gccccagggt aacaggaggc gcctcgccgg ccgcgcgctg gatgctgtga tccaggtccg      420

gagccgggtt ccgccgcggc cgcagcgacc cgaccccacc cgacaggcca gaggaatcag      480

tttagacttg aaattcagtt tttcctgaaa ctgatcagaa gttagtgaca ccttgattgg      540

atccgttttt ctgtcaggag ctcattttgc agctctcaag cttttatagc atgctgtaaa      600

caattgtcaa agttgtttat caagaaacag atagagttgc aacttgtttc tagtaataga      660

aacttttaca ctgcattcaa tgcctaacgt tgcagaaaca gaaaggtcaa atgattctgg      720

aaatggtgag cacaaatctg agagaaagtc acctgaagag aatctacaag gtgctgtaaa      780

atctttctgc acaagtgcct caggagcacc cttgggtccc aaaggagatg gtcattatcc      840

atggagttgt ccagtgactc atacacggga aaaaatttat gccatctgtt cggactatgc      900

ctttctcaac caggcgacct caatctataa aactccaaat ccatcccgct ctccttgcct      960

ccctgatagt acctctttat ctgctggaaa taattcatca agatacattg gtatcccgac     1020

tagtacatcg gaaattatct acaatgaaga aaatagcttg gaaaacttat ccaacagcct     1080

gggcaagcta cctctcgcat gggaaattga taaatctgaa tttgatgggg tgaccacaaa     1140

ttcgaaacac aaatcaggca atgcaaagaa acaagtttcc aagagaaaaa cttcagataa     1200

aaagggaaga tatcagaagg aatgtcctca gcattctcct cttgaagata ttaaacagcg     1260

gaaagtatta gacctcagac gatggtactg cataagccga ccacagtata agacttcttg     1320

tggcatctct tcattaattt cttgttggaa tttcttatac agcacaatgg gagctggaaa     1380

ccttccacct attacccaag aagaagcttt acatattctg ggctttcaac ctccatttga     1440

agatattagg tttggtcctt tcacggggaa tacaacactt atgaggtggt ttagacaaat     1500

taatgaccac ttccatgtaa aaggatgctc ttatgttcta tataagcctc atgggaagaa     1560

taaaacagca ggagaaactg cttcaggggc cctgtcaaag ttaacccgtg gattgaaaga     1620

tgaatcgctg gcttatatct atcattgcca aaatcattat ttttgtccaa ttggcttcga     1680

agcaacccct gttaaagcta ataaagcatt cagcagggga cctctctcac cacaggaagt     1740

tgaatattgg atcttaattg gagaatcaag tagaaaacat cctgccattc actgtaaaaa     1800

atgggcagat attgttactg atctaaacac tcaaaatcca gaatacctgg atatccggca     1860

cttagagagg ggactgcagt atagaaaaac aaagaaggtt gggggaaatt tgcattgcat     1920

catagcattc cagagactta actggcaaag atttggcctt tggaactttc catttggaac     1980

cattagacaa gaatcacaac ctccaacaca tgcccaggga attgccaaat ctgagagtga     2040

agacaatatt tccaagaagc agcatgggcg tctgggccgg tctttcagtg ctagtttcca     2100

tcaggactcg gcatggaaaa agatgtctag tatccatgag agaaggaaca gtggttacca     2160

gggttacagt gattacgatg ggaatgattg actatgcttg ctactgaaca gctggcatta     2220

tatatgaaac tgctatatac aggactgtat aaagacagta gaagatttta gtaagcctac     2280

attaaatagg agcagatctt gtggtataaa aaataacctt gtagttctcc agatactaag     2340

cttgtatatg attatggtgg gtgatttcag atatataagc agataagcac agattattgt     2400

cctttcaagt taagagtata taatctggac agaaaatttc acaaaattca ataaaattac     2460

aactgttgtc taaataagtg aaacacaaat tcacttaata gcatcaagat ttgaaatact     2520

taagcatgaa gtgactttta taatgactcg atccctagac atttgttaca gatagtttta     2580

tgcctaagac caagatgtaa agtaccatct gcccttaaaa aaaattgggg ctgtcaattt     2640

ctagttttca ctcatggtta acacgcattt aaaattattt catgagtcta gtagttcttt     2700

gatttatagc aggatcttgc ttgcctcatt tgtttcctgg ttatgttctt aggattctga     2760

ctaagaggca aaagagaaaa gactcaagaa actgatcctg gagatcgaga ccatcctggc     2820

taacatggtg aaaccccgtc tctactaaac atacaaaaaa ttagccgggt gtagtggtgg     2880

gcacctgtag tcctagctac tcgagaggct gaggcaggag aatggcgtga acccgggagg     2940

tggagcttgc agtgagcgga gatcgcgcca ctgcactcca gcctgggcga cagggcaaga     3000

ctctgtctca aaaaaaaaaa aaaaaaaaaa gacggatcct tttttttggt gcaaatgggt     3060

gacttagtgc attgattcag atttttaaaa tttcttgatg tggtttgtaa taatcaaata     3120

ttgacaagaa ccttaggtct cgaaagactt ttataagtct agatgacgtt tgccttaggg     3180

gtaaagtaaa agaacaattg gcaccttaag tttctatacc caaggttatc tgtgaaatga     3240

gatctcctga tatttgattg ctttctcagt atggagtcat atgttgataa cagtactgaa     3300

gatgcataag aaatgcccaa gtcactcaga ggacaactac ccatattcca gactctgagc     3360

tgtttccttt ttaaaaatca tatagacaat tagctgtttg aagtgagtat taaatatttc     3420

agaagtgtga atttcatgta tttgagctcc tctagttgct gttggttttt cttctgctgc     3480

caacctgtga ctcacaaatg actaggatct cttgttcttt aattttaggg tcttgttcca     3540

ggactcaaat cagtaacttg gtgattacaa ggtgctgaat gtgttggtaa ccatatcgca     3600

atacacctca aggaaaaggt tcagattttt atttttaaaa tattttcatt tttttcttga     3660

attttatatc cgtttgttca ctcgtacatg cctagcctac agaaggggat atatattatg     3720

aaatggtcat ttttctgaag agaatatttt gcttgaaatg caaaggactg aaagagattt     3780

gtaggttgtt gattttgtta cttcatactg gaacttttaa aaagatttca tcaaataaag     3840

ttttgttttc tactttt                                                    3857


<210> 335
<211> 1209
<212> DNA
<213> Homo sapiens

<400> 335
gagaggagtc tgcagagctc tgccgccacc agcacatccc tcctgtcaga gatcgagcag       60

agcatggagg ctgaggagct ggagcaggag cgagagcagc tgagactgca gctctgggaa      120

gcctactgcc aggttcgcta tctgtgctca caccttcgag gcaatgacag tgctgactca      180

gccgtctcca cggactcctc catggacgag tcttcagaaa cctcgtccgc caaggatgtg      240

ccagccggca gcttgcgcac tgccctcaat gagctcaaga gactgataca gagcattgtg      300

gatggcatgg agcccacggg ctcccggaga cttgatgatg actccttaga agaacagata      360

aggcagacca gtgaggactc gagagcccta agggagctca tggagggaga gaggggtaaa      420

ctgaggcaaa gcctagaaga gctgcagcga ctccacagtc aggtgacact gctgagtgtg      480

gagatgactg ccctaaaaga ggagagagac cgactcagag tcacttctga ggacaaggag      540

ccaaaggagc agcttcagaa ggccatcagg gaccgcgacg aggccattgc aaagaagaat      600

gctgtggagc tggaacttgc caagtgcagg atggatatga tgtctctgaa cagccagttg      660

ctggatgcca ttcagcagaa actgaacctc tcgcagcagc tggaagcttg gcaggatgac      720

atgcacaggg tcattgaccg gcagctgatg gacacgcacc tgaaagaacg gagccagccg      780

gctgctgccc tctgcagggg ccacagcgct gggcgggggg atgagcccag catcgctgaa      840

ggcaaacgac tcttctcatt cttcaggaaa atttaagttg ggaggagtca ggccaccaaa      900

gatgggtgga ctggaggcag ctggaaaggc ggtgcaggca aggcctcccc tgcagcttgc      960

acctcagcag ctgccctgcc cctcatgcta gggccccatg ggtccgggag ggcctgctcc     1020

ctttcgtcgg tggggatgga gacctagagg tgggggcctg ccttggccac tgaaggcttc     1080

ccttggccca ccgcctggcc aagcccacgc ctgggcttct ccaggaccac gtgcttgagc     1140

agggttaggc cacctcccag aggggcccct tggtgttggg ctttgcagct cacacccaac     1200

agatcgcag                                                             1209


<210> 336
<211> 2976
<212> DNA
<213> Homo sapiens

<400> 336
ggccgttccg acctccggtc aggaggggga ggaacagagc acggccggcg gctgcacggg       60

cagggcctct ctgggctgag aggaagaaac cagtgagaca tcgagaggaa gtcgctgtgg      120

cactcagtcc tacggcctcc gaggctgggt agtgagtgtg tcgctggcct tagccagact      180

ccacaggcca cgctggctgc gaatggagcc gaggactcgc gcggaggcga gatgctacca      240

gccggcgaga tcggcgcctc tcctgcagcc ccgtgctgct ctgaaagtgg tgacgaaagg      300

aagaacctcg aggagaaaag tgacataaat gttacagttc ttattggaag taaacaagtc      360

agtgaaggta cagataatgg tgatctccct tcttatgtgt ctgcattcat agaaaaggaa      420

gttggaaatg accttaaatc tttaaagaaa cttgataaac tcatagaaca gaggacagta      480

agtaaaatgc agttagaaga acaggtactt acaatttcat cagaaattcc taaaagaatt      540

cgaagtgcct taaaaaatgc agaagaatca aagcaatttc ttaatcagtt tctggagcag      600

gaaactcatc tcttcagcgc cattaacagc catttgctga ctgcgcaacc ttggatggac      660

gatcttggaa ccatgattag ccagattgaa gagatcgaac gtcatcttgc ttaccttaaa      720

tggatttcac aaattgaaga actaagtgat aacattcagc aatatctgat gaccaataat      780

gtaccggagg cagcctccac tctagtgtct atggcagaac ttgacattaa acttcaggaa      840

tcatcttgta ctcatcttct tggtttcatg agagccacag ttaaattctg gcataaaatt      900

ctcaaggaca agcttacaag tgattttgag gaaattttag cacagcttca ttggccattc      960

atcgcacccc ctcaatcaca aactgttggc ttaagtcgac ctgccagtgc cccggagata     1020

tacagttacc tggagacact gttttgtcag cttttgaaac tacaaacctc agatgaatta     1080

cttactgagc caaagcaact cccagaaaaa tactctcttc ctgcctcccc ttctgtcatc     1140

ctgcccatcc aggttatgct gactcctctt cagaagaggt tcaggtatca cttcagaggg     1200

aaccggcaga ctaatgtgtt aagcaagcca gaatggtact tggctcaagt acttatgtgg     1260

attggaaacc atactgaatt tctggatgag aagattcagc caatattaga caaagtaggc     1320

tctttggtaa acgcaaggct tgaattttct cggggcctta tgatgctggt tcttgagaag     1380

ttagccactg atattccttg tctgctatat gatgacaatc tcttctgtca tttggtggat     1440

gaagtactct tgtttgaaag ggagctacac agtgttcatg gctatcctgg cacttttgct     1500

agttgtatgc atattctatc agaggaaacc tgttttcaga gatggttgac ggtggagaga     1560

aaatttgctc ttcaaaaaat ggactcaatg ctttcctcag aagctgcctg ggtatcgcaa     1620

tataaggata tcactgacgt ggatgaaatg aaagttccag attgtgcaga aacttttatg     1680

actctactct tggttataac tgacaggtat aaaaatcttc ccacagcttc ccgaaagctt     1740

cagttcctgg agttacagaa ggacttagta gatgatttta ggatacgatt aacacaagtg     1800

atgaaagaag agactagagc ttcccttggc tttcgatact gtgcaattct taatgctgtg     1860

aactacatct caacagtact agcagattgg gctgacaatg ttttctttct acaacttcaa     1920

caggctgcac tggaggtgtt tgcagagaat aatactctga gtaaattgca gctaggacag     1980

ctagcctcta tggagagctc tgtctttgat gacatgatta acctcttaga acgtttaaag     2040

catgatatgt tgacccgtca agtagaccac gtttttagag aagttaaaga tgctgcaaaa     2100

ttgtataaaa aagaaagatg gttgtccttg ccatctcagt cagagcaggc agtgatgtcc     2160

ctgtccagtt cggcttgccc gttgctgctg acgttacgag accatttact tcagttggag     2220

cagcagcttt gtttctcctt atttaaaatt ttctggcaaa tgcttgtaga gaagctggat     2280

gtatacatct accaagaaat aattcttgct aatcacttca atgaaggagg agcagcccag     2340

ctgcagtttg atatgactcg gaatcttttc cctttgtttt ctcactattg caagagacca     2400

gaaaattatt ttaaacatat aaaagaagcc tgtattgttt tgaatttgaa cgtcggttct     2460

gcactactgc tgaaagatgt actgcagtca gcttcagggc agcttcctgc cacagcagca     2520

ttaaatgaag ttggaattta caaactggct caacaagatg ttgagattct acttaatttg     2580

aggacaaatt ggcctaatac tggaaaataa tgtctttcag aaaaaggttt ctttggtttt     2640

tgtttctaag aaagaggaag ccaattggat ttcaagttat atgatgaaat tctgaattaa     2700

tgaaactgga aaactttata gaattactta ttatcttgga tttatggtgt tattaaaatg     2760

ctgaccatat ttccttcatc ctcttgttcc taaggaaaca aaaacagaaa acgaaacaat     2820

gaaaactcaa ttctatttac aagtataaat gctgagtatg tctgttgaag acgagcagag     2880

atattaaatt ataaccaact ttcaatttcc tgtgctaatt aagggaaatt ctgttgtgga     2940

taatcaaaca tagccaataa atttttttaa aactcc                               2976


<210> 337
<211> 4598
<212> DNA
<213> Homo sapiens

<400> 337
cccaggccgg ctctggcctc ctgacccaga cagcgcaggg cgcgagggat cgcgcggccg       60

agcccgggtc gcgccgctcc cagcatcggg gccgctagcc aagagttcga ggccttcccg      120

atccggatgt gatgaaaaag agcaacagag ggagaagtgt ttcaggattg taggagtgga      180

agaggggaaa gagaggcaga gagggggaag gccccctcgc aggggagccg gctggagtga      240

gctggctgga aagagggggc ggagtgcgcg gagtcagagc cgccaccgct gccgcagttg      300

ccgccactgc ggcgtctggg ctgagccgga gggaggcggg aggacgcgca ggggcggccg      360

ccgccgtcgt caggccaccg gggcgaaaat gcggccgctg ccggaggctc gctaactttc      420

cggggcggaa gaggaggagg aggaggagga aggggcttgg agcgactacg gggggatgcg      480

gagaagcagt cagttccctg cacccagcac ctcacagccc ttcctccgtg cgccctgccg      540

ggcggcgagc taggcggcag cggcgcggcg cgggctcggc ggagcggccc atgtccggcg      600

cgggcgaagc cctcgctccc gggcccgtgg ggccgcagcg cgtggccgag gcgggcggcg      660

gccagctggg ctccacagcc cagggaaaat gtgataaaga caatactgag aaagatataa      720

ctcaagctac caatagccac ttcacacatg gagagatgca agaccagtcc atttggggaa      780

atccttcgga tggtgaactc attagaaccc aacctcagcg cttgcctcag cttcagactt      840

cagcccaggt gccaagtggt gaggaaatag gcaagataaa gaacggccac acaggtctga      900

gcaatggaaa tggaattcac cacggggcca aacacggatc cgcagataat cgcaaacttt      960

cagcacctgt ttctcaaaaa atgcatagaa aaattcagtc cagcttgtct gtaaacagcg     1020

atatcagtaa gaagagcaaa gtaaatgctg tcttttccca aaagacaggc tcttcacctg     1080

aagattgttg tgtccactgt atcctggctt gcttgttctg cgaattcctg accctttgca     1140

acattgtcct gggacaagcg tcatgtggca tctgcacctc agaagcctgc tgctgttgct     1200

gtggtgacga gatgggggat gattgtaact gcccttgtga tatggactgt ggcatcatgg     1260

atgcctgttg tgaatcatca gactgcttgg aaatctgtat ggaatgctgt ggaatttgtt     1320

ttccttcata aatatttatc ttttgtttgt gttaaaactg gagagtgttt aaaaatttcc     1380

ttttgggggg aagaaaagca cattgtaaga ttctcatgaa acaacatgga atttgcactg     1440

ttaactcatt attgtaagta atctctgaaa gcctttttac tttaaccaaa tctacatggt     1500

ttaatatgtg aaattttaac tactttaact agttttataa atttcttaat atgttacaat     1560

aacttaggga cattttgaca ccccccttcc caaatgttaa atgccttctc ctttttaccg     1620

atatttctgt ttcttttaac cgttctcagg agcactttgc tccaaatata ttatttttca     1680

gtgtgtattt aaacgaggca gtttattttg atatgtatct attcatgatt gaaaggaagc     1740

agtcttggcc aggcacggtg gcttacacct gtaaccctgg cattttggga ggccaaggtg     1800

ggcagattgc ctgagctcag gagttcgaga ccagccaggg caacatggtg aaaccccatc     1860

tctactaaaa tacaaaaagt tagctgggct tggcggtgtg cgcctgtagt cccagctact     1920

caggaggctg aggcaggaga attgcttgaa cccgagaggc ggaagttgca gtgagccgag     1980

attgtgccac tgaactccaa cctgcactcc agcctgggca acagagcgag actccatctc     2040

taaataaata aataaataaa taaataaata aataaataaa taaacaaacc agtctttatt     2100

ttaaaagaaa ctttaggaaa caaacccaca taatagttgg gaaccagtgt tgatctctct     2160

cccttacctt ctccacttgt tcaacagact ctgaatgccg actgtgtgga ctctcttcct     2220

cagactgtgg ggacagatac aattccactc ctgtccacag gaacatgaga tttagcagac     2280

taaggagatc tgtaaagaat gaaccatacc acaaggcata ctgaagtgag gattataaga     2340

gaaataaact caaaatgctg ttggaatatg cagagaattg ctaccagaat attcagtaag     2400

gtttcaggga gaatgtggca tttgaggact ctcttagaat gagtgattca cctgctattt     2460

aaatgaatta tttagatttt tgacaaagat ttaggtggac accctaaact gtgtgtgcct     2520

ttaaccagtt aaaagaacag tgccttcagc atactttttt attagttgta ggaatacagc     2580

tttttgaaaa agctataaag tttaaattaa ctaaaaatat gcattttctt acacataatt     2640

taaatgttat catacttttt tgatgaaaac ataatgcctt agtaaaatag ctctatttaa     2700

taaagaagat tgagtactct gacacatttc atttaaatta ggaaattttt aatattaaaa     2760

tcccagtgtt ctgagttatt gaaaggcttt cttttatttt gagagcttta ggtctttttg     2820

ggatgagaac attttagttg tttagtttgt ttcttaagca gtgctatttt ttgtaaacac     2880

agataaatgg aaaccattct tttcaatgca gaagaaatct agatatcccc tactgtgacc     2940

aaatttctgt attacgattt tatgttaaat taaactaata tggcaggtta taatgatcct     3000

taagtgtaaa gaaatcagtc aattacaaga gtaattgtat agttattgag acctatagtg     3060

tgtggcttag atgaaaggga gagtaaattt tcataccatg ctctctccta ctcagtttga     3120

tctctctaaa attgtagttt ggtttgattt aatataattc ttagtagaaa ttttgaaagt     3180

atgctttggg attaataatt atttttaatt tttctggctg aatatcaaat tgatagtaac     3240

aacagaagca taattttagg aaggctttcg caaacctagc cttttaagag aggtttttaa     3300

cctgaagcat gagaatatat cacctgtggt ttttcctttg agatgaaacg tagtttctag     3360

ttatatcatt acttaaaggg cttaaaaaga aaaaacttag caaacttttg aatctttctt     3420

ttattgctat ttacacatac atacacacat acaaaacctt taaattttgg gatctgaata     3480

taattctggt aaacagctgt cttcattttt ctcctctaaa gaacttaatt catttgttac     3540

ataaaatata aggaaatctt tatactattt tacagtaacc acaatctaaa tatttacata     3600

tacccaaaat taacttatgc tcatatatta ggatgtgaga atatcatctg tttatggaca     3660

catgaaacct cctaatgacc tggaattgtt agaatatttg actttttata tgcaaagttt     3720

ttcaaccaag tggtttgtct aatatttaaa catgtactgg cacaatttgt gatgaaaata     3780

ttagcacatt tgcaataatg tttctccata acagagaatg ttaatggata ccagaatttt     3840

atttttgtat ttatgttcat agtacttttc ctcttgtcta ctccagacag ttattccata     3900

aagcatttgt ataattaaaa ggaaaacaga aaaaggaaaa gtaggcaaat gtgaaaatag     3960

tttcaatata tcttatgatt tcttaatgta aaatgttttg ttgaagtata tggctatcat     4020

gactaagtgc tagaatttat agttacaggc ggtgtccttt taaatgtgga aaggctttta     4080

aaatatttta aaactggacc tgtattatcc tgaatacact attttgaaaa tttttaaaaa     4140

tgacttcttt attttgcttt accgtatgtt tatatctaat tgacatattg actaatgttt     4200

gaaagaattc aaccataagt taaaatctga aggttatctt tatcatgttt catccctgtc     4260

tgaagatttc ctagtcttct tatgtaaatc acatgactca tgtccgtaaa tgaactatga     4320

aagatatcga tcagtttatg atcattgaca tgtgatttca aaacacagtg ttcttttaaa     4380

aatctataat atgtcaaaat acaagttttt tttttttaca tcgttttagt aagttaattt     4440

catttattta ctttggagct atatttccac ttagaaaaac taaggtaatt ttacaatata     4500

tgctgagatt aaaaaccaag gtaaaaatga tcaaacatat atgaaattga gtcttagatt     4560

taatgaattt cactcgaaaa taaatgatca gaagaatt                             4598


<210> 338
<211> 572
<212> DNA
<213> Homo sapiens

<400> 338
acagcggtca cgtgacatgg ccccggggag ccgaggtgag cgttccagct tccggagccg       60

gagggggccc ggcgtaccca gcccccagcc cgacgtgacc atgctgtccc gcctcctaaa      120

agaacaccag gccaagcaga atgaacgcaa ggagctgcag gaaaagagga ggcgagaggc      180

tatcactgca gcgacctgcc tgacagaagc tttggtggat cacctcaatg tgggtgtggc      240

ccaggcctac atgaaccaga gaaagctgga ccatgaggtg aagaccctac aggtccaggc      300

tgcccaattt gccaagcaga caggccagtg gatcggaatg gtggagaact tcaaccaggc      360

actcaaggaa attggggatg tggagaactg ggctcggagc atcgagctgg acatgcgcac      420

cattgccact gcactggaat atgtctacaa agggcagctg cagtctgccc cttcctagcc      480

cctgttccct cccccaaccc tatccctcct acctcacccg cagggggaag gagggaggct      540

gacaagcctt gaataaaaca caagcctccg tt                                    572


<210> 339
<211> 2527
<212> DNA
<213> Homo sapiens

<400> 339
ctccagcagc acccgagagg gtcaggagaa aagcggagga agctgggtag gccctgaggg       60

gcctcggtaa gccatcatga ccacccggca agccacgaag gatcccctcc tccggggtgt      120

atctcctacc cctagcaaga ttccggtacg ctctcagaaa cgcacgcctt tccccactgt      180

tacatcgtgc gccgtggacc aggagaacca agatccaagg agatgggtgc agaaaccacc      240

gctcaatatt caacgccccc tcgttgattc agcaggcccc aggccgaaag ccaggcacca      300

ggcagagaca tcacaaagat tggtggggat cagtcagcct cggaacccct tggaagagct      360

caggcctagc cctaggggtc aaaatgtggg gcctgggccc cctgcccaga cagaggctcc      420

agggaccata gagtttgtgg ctgaccctgc agccctggcc accatcctgt caggtgaggg      480

tgtgaagagc tgtcacctgg ggcgccagcc tagtctggct aaaagagtac tggttcgagg      540

aagtcaggga ggcaccaccc agagggtcca gggtgttcgg gcctctgcat atttggcccc      600

cagaaccccc acccaccgac tggaccctgc cagggcttcc tgcttctcta ggctggaggg      660

accaggacct cgaggccgga cattgtgccc ccagaggcta caggctctga tttcaccttc      720

aggaccttcc tttcaccctt ccactcgccc cagtttccag gagctaagaa gggagacagc      780

tggcagcagc cggacttcag tgagccaggc ctcaggattg ctcctggaga ccccagtcca      840

gcctgctttc tctcttccta aaggagaacg cgaggttgtc actcactcag atgaaggagg      900

tgtggcctct cttggtctgg cccagcgagt accattaaga gaaaaccgag aaatgtcaca      960

taccagggac agccatgact cccacctgat gccctcccct gcccctgtgg cccagccctt     1020

gcctggccat gtggtgccat gtccatcacc ctttggacgg gctcagcgtg taccctcccc     1080

aggccctcca actctgacct catattcagt gttgcggcgt ctcaccgttc aacctaaaac     1140

ccggttcaca cccatgccat caacccccag agttcagcag gcccagtggc tgcgtggtgt     1200

ctcccctcag tcctgctctg aagatcctgc cctgccctgg gagcaggttg ccgtccggtt     1260

gtttgaccag gagagttgta taaggtcact ggagggttct gggaaaccac cggtggccac     1320

tccttctgga ccccactcta acagaacccc cagcctccag gaggtgaaga ttcaacgcat     1380

cggtatcctg caacagctgt tgagacagga agtagagggg ctggtagggg gccagtgtgt     1440

ccctcttaat ggaggctctt ctctggatat ggttgaactt cagcccctgc tgactgagat     1500

ttctagaact ctgaatgcca cagagcataa ctctgggact tcccaccttc ctggactgtt     1560

aaaacactca gggctgccaa agccctgtct tccagaggag tgcggggaac cacagccctg     1620

ccctccggca gagcctgggc ccccagaggc cttctgtagg agtgagcctg agataccaga     1680

gccctccctc caggaacagc ttgaagtacc agagccctac cctccagcag aacccaggcc     1740

cctagagtcc tgctgtagga gtgagcctga gataccggag tcctctcgcc aggaacagct     1800

tgaggtacct gagccctgcc ctccagcaga acccaggccc ctagagtcct actgtaggat     1860

tgagcctgag ataccggagt cctctcgcca ggaacagctt gaggtacctg agccctgccc     1920

tccagcagaa cccgggcccc ttcagcccag cacccagggg cagtctggac ccccagggcc     1980

ctgccctagg gtagagctgg gggcatcaga gccctgcacc ctggaacata gaagtctaga     2040

gtccagtcta ccaccctgct gcagtcagtg ggctccagca accaccagcc tgatcttctc     2100

ttcccaacac ccgctttgtg ccagcccccc tatctgctca ctccagtctt tgagaccccc     2160

agcaggccag gcaggcctca gcaatctggc ccctcgaacc ctagccctga gggagcgcct     2220

caaatcgtgt ttaaccgcca tccactgctt ccacgaggct cgtctggacg atgagtgtgc     2280

cttttacacc agccgagccc ctccctcagg ccccacccgg gtctgcacca accctgtggc     2340

tacattactc gaatggcagg atgccctgtg tttcattcca gttggttctg ctgcccccca     2400

gggctctcca tgatgagaca accactcctg ccctgccgta cttcttcctt ttagccctta     2460

tttattgtcg gtctgcccat gggactggga gccgcccact tttgtcctca ataaagtttc     2520

taaagta                                                               2527


<210> 340
<211> 2092
<212> DNA
<213> Homo sapiens

<400> 340
agagggactc ccagctccag ctcacccatt ctacacttgc tcttttgctc ccaaccagga       60

agccatcatg tcttgccgct cctaccgagt cagctctggt caccgggtgg gcaacttcag      120

ctcttgttca gcaatgacac cacagaacct gaatcgcttc cgggccaact ctgtctcctg      180

ttggagtggg cctggattcc ggggccttgg cagctttggt agtcggagtg tcatcacctt      240

tggatcgtac tcaccccgga tagcagctgt aggctctcgg cccatccact gtggagtccg      300

ctttggtgct ggctgtggga tgggttttgg tgatgggaga ggtgttggtc tggggcctag      360

ggctgacagc tgtgttggtc tgggctttgg agctggcagt ggcattggct atggctttgg      420

tggccctggc tttggttaca gagttggagg ggttggagtc ccagcagccc catctatcac      480

agctgtgact gtgaacaaga gcctactgac ccccctcaac ctggagattg accccaatgc      540

ccagagggtg aagaaggatg agaaggagca aatcaagacc ctcaacaaca agtttgcctc      600

cttcattgac aaggttcggt tcctagagca gcagaataag ctcctagaga ccaagtggag      660

cttcctccaa gagcagaaat gtatcaggag caatctggag ccactcttcg agagctacat      720

caccaacctg cggaggcagt tggaggtgct ggtcagtgat caggcccggc tccaggctga      780

gaggaaccac ctgcaggatg tcctagaggg cttcaagaag aagtatgaag aggaagtggt      840

atgtcgggcc aatgctgaga atgagtttgt ggctctgaag aaggatgtgg atgcagcttt      900

catgaacaag tctgatctcg aggccaacgt ggatacccta actcaggaaa ttgactttct      960

aaaaacgctt tacatggagg aaatccagtt gctgcagtcg cacatctcag agacgtcggt     1020

cattgtgaag atggacaaca gccgtgacct gaaccttgat gggatcattg ctgaggtcaa     1080

ggcccagtat gaggaggtgg ccaggcgcag ccgggctgat gctgaggcct ggtaccagac     1140

caagtatgaa gagatgcagg tgacagctgg ccaacactgt gacaacctgc gcaacatacg     1200

gaacgagatc aacgaactga cccgcctgat ccagaggctt aaggcagaga ttgagcacgc     1260

caaggctcag cgtgccaagt tggaggctgc agtggccgag gccgagcagc agggcgaggc     1320

gaccctcagt gatgccaaat gcaagctggc agatctggag tgtgccctgc agcaggccaa     1380

gcaggacatg gcgcggcagc tgtgcgagta ccaggagctg atgaatgcca agctgggcct     1440

ggacatcgag atcgccacct acaggcgcct gctggagggc gaggagagcc ggctctgtga     1500

aggtgttgga ccagtaaaca tatccgtcag cagctcccgg ggcggcctgg tgtgcgggcc     1560

tgagcctttg gttgccggct ccaccctctc ccgcggcggg gtcaccttct caggtagcag     1620

cagcgtctgt gccaccagtg gggtcctggc ttcctgtggc cccagcctgg gtggagcccg     1680

ggtcgccccg gccactgggg acctgctgag cactggcaca aggagtggct ccatgctcat     1740

cagcgaggcc tgtgtcccca gcgtcccctg ccccctgccc acccaggggg gcttcagcag     1800

ctgcagcggc ggccgcagct ccagcgtccg ctttgtgtcc accaccacct cctgccggac     1860

caagtactga gagcccagcc ccagacagct gctgcccaga gaagaaccag ctccacggct     1920

cctgcttctg cccccagggt tcgtgggctc tgggcttgac ggtctccagc tcccctttct     1980

gccaggaagc caccccttag cactcccccg attattctgc ctggccccat gtcctcttgg     2040

aggatttttc tgccatgtag atgctccatt agcagttcca gctaagctgg ct             2092


<210> 341
<211> 2664
<212> DNA
<213> Homo sapiens

<400> 341
gggaagctga gcctgacttg atcatcctgc cccggttctt tcctccaggg ccgcatttct       60

ctgcctctct ctcctgccat gtcgtaccac tctttccagc caggctccag gtgtggcagt      120

cagagtttca gctcatactc ggctgtcatg ccccggatgg tcacccacta tgcagtgagc      180

aaggggccat gccggcccgg gggtggtagg ggcctccgag ctctgggctg ccttggctca      240

cggagcctgt gcaacgtggg ctttgggagg ccccgggtag cctccaggtg tggaggtacc      300

ctgcctggct tcgggtaccg actgggagcc acctgtgggc cttctgcctg catcacccct      360

gtcaccatca atgagagcct gctggtccca ctggcactgg agatagaccc gactgtgcag      420

agggtaaaga gggatgagaa ggagcagatc aagtgcctca acaaccgttt cgcatctttc      480

atcaacaagg tccgtttcct ggagcagaag aacaagctgc tggagaccaa gtggaacttc      540

atgcagcagc agaggtgctg ccagaccaac atcgagccca tcttcgaggg ctatatcagc      600

gcccttcggc ggcagctgga ctgtgtgtcc ggggaccgcg tgaggctaga gtcagagctc      660

tgcagcctcc aggctgcact ggagggctac aagaaaaaat acgaagagga gctctccctg      720

cgtccctgtg ttgagaatga gtttgttgcc ttgaagaagg acgtggacac agccttcctg      780

atgaaggctg acctggagac caacgcagag gcactcgtgc aggagatcga cttcctgaaa      840

agcctgtatg aggaggagat ctgcctgctc cagtctcaga tctctgagac ctcggtcatt      900

gtgaagatgg acaacagccg ggagctggac gtggacggca tcatcgctga gatcaaggcg      960

cagtatgacg acatcgccag ccgcagcaaa gccgaagcag aggcctggta ccagtgccgg     1020

tatgaggagc tgagagtcac agctgggaac cactgtgaca acctccgcaa ccgtaagaac     1080

gagatcctgg aaatgaataa actgatccag cggctgcagc aagaaaccga gaatgtcaaa     1140

gcccagcgct gcaaacttga gggtgccata gctgaggcag agcagcaggg cgaggcggct     1200

ctcaatgatg ccaagtgcaa gctggcaggg ctggaggagg ctctgcagaa ggccaagcag     1260

gacatggcct gcctgctcaa ggaatatcag gaggtgatga actccaagct gggcctggac     1320

atcgagatcg ccacctacag gcgcctgctg gagggtgaag agcacaggct gtgcgaaggc     1380

atcgggcccg tgaatatctc agtgagcagc tccaaaggcg ccttcctgta cgagccatgt     1440

ggggtcagca cgcctgtcct cagcactggc gtcctcagga gcaatggggg ctgcagcatc     1500

gtgggcactg gtgaactcta tgtcccctgc gagccccagg ggctactgag ctgtgggagc     1560

gggcggaaat ccagcatgac gctaggagct gggggcagct cccccagcca caagcattag     1620

catgatccga gacatccagg agacagagcc cctgccccat ggccctggat gtcacactcc     1680

caccagggct gaagacaagg atgttccaaa accccacctc cctttattga ctccacattc     1740

ccctccagtg ttccctcctt gagagctgag ctgcccctag gacccctcct ttgcctcatg     1800

agtcaccttc cactcacctg tgtgcagacc ctcagctagg cccagatggt ggggacagac     1860

ggcagagaaa gagcatgcat tgctcttaac cgcagaatgg caataacccc caaaaggtca     1920

aatgggcaca ccacagttct gctctgtgga tcatcccatg gaagtttcct cacaaagtca     1980

gctcctctcc caccacaggc tcacactgcc cttactttag gctctcatgc ccctaagaaa     2040

agtgaatttc ctttaacacc gcctgaaaca tgcacactgc aaatatcaaa aggagacacc     2100

cccaaatccc actctaaatt ccaaagccaa gtgccacgat ttcaggatca gtcaggacct     2160

gccaatgtcc tctcagcaca gagaatcaag aggtggcctt tgggcagtag atttactttc     2220

tcaggtatgt tgaacccaaa ctgtgagaat aaatctttct cctgagctca cattggcagg     2280

tgatgtcagg ccaatgccta gaacaaaggg caaagggata tggaatgttt actggacagt     2340

tggaaaacca aaaacagata ccattttctc aatggaatca gttccccctc cacccatccc     2400

cttctgtaca tagccgcccc ttcctgttcc ccaacccttt agctcctttt gctttgagtc     2460

tgatatgaca gtgatgtggg gctgccccag ctgacttgga ggccctggct caggagctca     2520

tagatggagg aggtgtgggc tgactacctc ccagaagccc ctcatgccaa gcctgtccca     2580

ctggggctcc agggcctctg ccctgaacat ctgggcttct gttcaaaata aacctactct     2640

gttcatggat tatagcaatc agga                                            2664


<210> 342
<211> 1916
<212> DNA
<213> Homo sapiens

<400> 342
agagtagcgg aagtggtccg ttctcttcct ctcccggccc aagcttctgg gtatttctat       60

tgcgcgaggc attgtgggtt gctgggcggc ccggtctcgg agaagagggg agagtggcgg      120

gccgctgaat aagcttccaa aatgatgccc acaccagtta tcctattgaa agaggggact      180

gatagctccc aaggcatccc ccagcttgtg agtaacatca gtgcctgcca ggtgattgct      240

gaggctgtaa gaactaccct gggtccccgt ggcatggaca agcttattgt agatggcaga      300

ggcaaagcaa caatttctaa tgatggggcc acaattctga aacttcttga tgttgtccat      360

cctgcagcaa agactttggt agacattgcc aaatcccaag atgctgaggt gggtgatggc      420

accacctcag tgaccttgct ggctgcagag tttctgaagc aggtgaaacc ctatgtggag      480

gaaggtttac acccccagat catcattcga gctttccgca cagccaccca gctggcagtt      540

aacaagatca aagagattgc tgtgaccgtg aagaaggcag ataaagtgga gcagaggaag      600

ctgctggaaa agtgtgccat gaccgctctg agctccaagc tgatctccca gcagaaagct      660

ttctttgcta agatggtggt ggatgcagtg atgatgctcg atgatttgct gcagcttaaa      720

atgattggaa tcaagaaggt acagggtgga gccctcgagg attctcagct ggtagctggt      780

gttgcattca agaagacttt ctcttacgct gggtttgaaa tgcaacccaa aaagtaccac      840

aatcccaaga ttgccctttt gaatgtcgag ctcgagttga aagctgagaa agacaatgct      900

gagataagag tccacacagt tgaggattat caggcaattg ttgatgctga gtggaacatt      960

ctctatgaca agttagagaa gatccatcat tctggagcca aagttgtctt gtccaaactc     1020

cccattgggg atgtggccac ccagtacttt gctgacaggg acatgttctg tgctggccga     1080

gtacctgagg aggatctgaa gaggacaatg atggcctgtg gaggctcaat ccagaccagt     1140

gtgaatgctc tgtcagcaga tgtgctgggt cgatgccagg tgtttgaaga gacccagatt     1200

ggaggcgaga ggtacaattt ttttactggc tgccccaagg ccaagacatg caccttcatt     1260

ctccgtggcg gcgccgagca gtttatggag gagacagagc ggtccctgca tgatgccatc     1320

atgatcgtca ggagggccat caagaatgat tcagtggtgg ctggtggcgg ggccattgag     1380

atggaactct ccaagtacct gcgggattac tcaaggacta ttccaggaaa acagcagctg     1440

ttgattgggg catatgccaa ggccttggag attatcccac gccagctgtg tgacaatgct     1500

ggctttgatg ccacaaacat tctcaacaag ctgcgggctc ggcatgccca ggggggtaca     1560

tggtatggag tagacatcaa caacgaggac attgctgaca actttgaagc tttcgtgtgg     1620

gagccagcta tggtgcggat caatgcgctg acagcagcct ctgaggctgc gtgcctgatc     1680

gtgtctgtag atgaaaccat caagaacccc cgctcgactg tggatgctcc cacagcagca     1740

ggccggggcc gtggtcgtgg ccgcccccac tgagaggcac cccacccatc acatggctgg     1800

ctggctgctg ggtgcactta ccctccttgg cttggttact tcattttaca aggaaggggt     1860

agtaattggc ccactctctt cttactggag gctatttaaa taaaatgtaa gacttc         1916


<210> 343
<211> 4515
<212> DNA
<213> Homo sapiens

<400> 343
gccgcccgcc acctcggcgg cctcgcaacc cgtgggagcc cgtggccatc gcagacctag       60

aggacacgtt gggcggcgca gtcgccgcgg caaggtcggc gggcggcgcg gcgcgaggga      120

cggcgagcgg ggggcggccc ggcccgggtc ctcgcgggtc ctcggcgggc ccgggggagg      180

gccctctttg tggctgcagt tggcaagatg gcgccggtgg gggtggagaa gaagctgctg      240

ctaggtccca acgggcccgc ggtggcggcc gccggcgacc tgaccagtga ggaggaggaa      300

ggccagagcc tatggtcctc cattctgagc gaagtgtcca cccgcgccag gtccaagctg      360

ccgtccggca agaacatcct ggtcttcggt gaagatggtt ctggtaaaac aaccctcatg      420

actaaactac aaggagctga gcatggcaaa aaaggaagag gcctagaata tctctacctc      480

agtgtccatg atgaggaccg agatgatcac acgcgctgca acgtgtggat tctggatgga      540

gacttgtacc acaaaggcct gctgaaattt gcagtttctg ctgaatcctt gccagagacc      600

ctcgtcattt ttgttgcaga catgtctaga ccttggactg tgatggaatc tctgcagaaa      660

tgggctagtg ttttacgtga gcacattgat aaaatgaaaa ttccaccaga aaaaatgagg      720

gagctggaac ggaagtttgt gaaagatttt caagactata tggaacctga agaaggttgt      780

caaggttccc cacagagaag aggccctctg acctcaggct ccgatgaaga aaatgttgcc      840

ctgcctctgg gtgacaatgt gctgactcat aacctgggga tcccggtgtt ggtggtgtgc      900

acaaagtgtg atgcggtgag tgtcctggag aaggagcacg attacaggga tgagcatttg      960

gactttatcc agtcacacct gcggaggttc tgccttcagt atggagctgc cttgatttac     1020

acatcagtga aagaagagaa aaacctcgac ttgttgtata agtatattgt tcataaaaca     1080

tacggtttcc acttcaccac acctgcctta gttgtggaaa aggatgccgt ttttatacct     1140

gcaggctggg acaatgaaaa gaaaatagct attttacatg aaaattttac aaccgtgaag     1200

ccggaagatg catatgaaga ctttattgtg aaacctcccg tgagaaagct ggtccacgac     1260

aaagagttgg cagcagaaga tgagcaggtg ttcctaatga agcaacagtc actccttgcc     1320

aagcaaccag ccactcccac gagagcttct gaatctcctg caagaggacc ctctggctct     1380

ccaaggaccc agggtcgggg agggccagcc agtgtgccta gctcctcccc aggcacgtca     1440

gtaaaaaagc cggacccaaa catcaaaaat aatgcagcaa gtgaaggggt gttggccagc     1500

ttcttcaaca gtctgttgag taaaaagaca ggctctcctg gaagtcctgg tgctggtggg     1560

gtgcagagca cagccaagaa gtcaggacaa aagactgtgt tgtcaaatgt tcaggaagaa     1620

ctggatagaa tgactcgaaa gccagactct atggtaacaa actcttcaac agaaaatgaa     1680

gcctgaacct ccttaaaaag tgcatatgtc gaatgaccaa ataactatgt atattgatct     1740

gctaagacca ggatttttct gatatggcac atgctatcag ttttttgggg caggggagat     1800

gaactttaaa aaaaaaaaaa aaacttcatt ggcttgtccg agtgtgaaat gcacatttag     1860

gaaggttaca tgtcagaccc tttgttaagg ataacccttg gactctgggg catgtggctc     1920

ttttgtggga ggcaagcaca tctgggcttc ttgtggaggg gaaggtagag tgaaagaaag     1980

agggcccact ttctaacagg gtggagcaaa tgagaccaag aaatcattgg taagatgatg     2040

gttagtctga ccagtttcat gttagtaaat tcacttgttc ttgggaagca gattaagtag     2100

cagaaagtcc aggaaagaaa gaccagaagg agtaatgaga caagtgatgg tggggaagct     2160

gaatgttgag ggaggtggag gaaggaggag atgagcagtg tcagtaaata ctgtgcattc     2220

agtagaagtt gaagaatcat tgttagaagc atttccaaac aaaacactaa gcaaaatggg     2280

aattaggctt attttgaatg catctttaac ttacgaaaga tgtactaatt gtgggggtgc     2340

ctgagtcagg cggagctgac ccaggggtgg gaacgatggc agctgcccag gacccatgtg     2400

cttggcccag gctatgtcct cgtgagaggt actggggtcc acggatatgt gttgtggggc     2460

agacagtcac tgtgggatgt cttcaaagtc agcagttaca gaattagttt actttgaatt     2520

ttgttgtcta aatagctcct gctttatttt ttaaattaaa ttttttgttt ttactatcac     2580

aggctggcct aactaataca aaataggtga tgaacctctg gttttaccat aatgcaatgt     2640

gccacggaaa gtttggggga ggtttttaat gtaattgcac tctggttaat tggctcgtac     2700

caagccctgc cttatgactt gtggaaagct tcaaggagtt ccactgatgc aaaagggtct     2760

tttcctagct tcctggtctg atcagtgcta tgagatggac agataagtgt gaatgtttta     2820

tacagaaaat ggaaatgata catttctctt gttaggtgtt ttcataaaat gtagcatttt     2880

ttttcttatg gaaataagag tttcaggtgt ctccccacct agggcaaatt catgcacatt     2940

gtcatgttat accaccattc tggaaatgat ttctgtggat ttgaaattgc acttttaatt     3000

ttatatatga cagcatttaa atgcaaacac taccatgaat ttaatgtata aaatgttgtc     3060

aaaccaaggg aaaaaaccac agttcaccat gtggagttta ctttttttat atgaatgttt     3120

gttgtactgt gtctaagcat aacttcccta atgtcattac ttttacatac cagatttgac     3180

tgaccactaa tgtagtactg gggataactt aatatcctat gttgtgtcaa gactctttga     3240

agactttctt gaattgcttt cgtaaaggtc tgaacactgt taaggagaaa gctgagtatc     3300

aacttgcctt tctgatagaa atgtttcttg tgccagtttt attgttgaga tatactattt     3360

ttttcctttt ttaattcagt tttttaaaaa aacaaatgta ttgtggcttc cagttaccag     3420

gttgtctagg taatgacagt aaactgactg tagaatgata attgtggtat agtgaccaat     3480

agatgccaaa cagcttgtgg cctcactaaa ggtggggtcg cttagtcccc gggagtaaaa     3540

tgagtgacct cagaaacaag aattcctgga aaggcacatg ccgaagagga atatggtata     3600

attttaaatt ttaatgcaaa attttaattt gtctttattt tttatcattt gaactgataa     3660

gcactttttg tgtcaatata aaatatacta aaactgatga aatgctaaga catgtcttgt     3720

gaaggaaggt ttcttggaga ccacttttat ttactcatga gaagtggaag ctcctagtat     3780

cagaagaagc tgatacatag tgtcatgtgc tcagtggttg ccaaagtcta ccaactttgg     3840

ggagctgcag ggttcttttt gggaggtggg aggaagggag atgagttttg ttattttggg     3900

gttttcaagc attggaacca aaggccaaat aataaacagc ctttagtttt taaagtaaaa     3960

ttcattttat ttgcagagta cacttgtatg gtagactgtt aaagacaatt ttatgactat     4020

ttatgcacat tataatggtt acatctgctt tttgtcttta aaataaaaaa aaaaatcaga     4080

gaaaagccca cctttgaata cgtggctgaa gataacagcc aagaattggt ctttcctaaa     4140

aatgcaacag ataatgctgc tagattgtta ttttgtttgc actttttttt gattggcatt     4200

ttaaaatcgg tatttaaact gaagacattg tcatgtttta ttaatttaac aaagttgaaa     4260

gtgactgctc tgtacatcat gaccttaaca atgttaatgc tgtaagtgaa agttcactgt     4320

cgtctgtata ctaaatttat tggtgtttct aacttaaaag taagactgca gattatcccc     4380

caccagcctt agtccagggg tgtggctctg tccgggtgca gtatgcagtc atgtggaacc     4440

ttgctttcta gtcctgggaa aaaaagatgt ctctaattac tggcttcaat aaacacgaat     4500

ccagactgct tacaa                                                      4515


<210> 344
<211> 880
<212> DNA
<213> Homo sapiens

<400> 344
acacaaaggg gtggtcaccc tgccctcacc ttgacctgta agttgcctag gacagtggcc       60

tggtcccagg ggctgttgtg gggagttgaa gaacaccctg gcctcctcca tcatgtcggc      120

caagagggca gaattgaaga aaacacatct gagcaagaac tacaaggcag tttgcctgga      180

attgaagcca gagccgacca aaacatttga ttacaaagca gttaaacaag aagggcggtt      240

taccaaagca ggagtgacac aggacctaaa gaatgaactc agggaagtga gagaagagct      300

caaggagaaa atggaggaga taaaacagat aaaggatcta atggacaagg attttgataa      360

acttcacgaa tttgtggaaa ttatgaagga aatgcagaaa gatatggatg agaagatgga      420

cattttaata aatacacaga agaactataa gcttcccctt agaagagcac caaaggagca      480

gcaggaactc aggctgatgg gaaagactca cagagaacca cagctcaggc ccaagaaaat      540

ggatggagcc agtggagtca atggagcacc ctgtgctctt cacaagaaga cgatggcacc      600

acaaaaaaca aaacagggct cactggatcc ccttcatcac tgtgggacct gctgcgagaa      660

atgtttgttg tgtgctctaa agaacaacta caatcgggct gctcccctaa aggaagctcg      720

tcacctcctg acagccaatt ctattgaccc ttctgcagct cttgttcttc tgattgagtt      780

cctgcttttg accctggtaa caggtgcggc agccccaggc cttgacgcat gtggtcatca      840

gagaaacatg agggatgaaa taaactcaga gagaaggtaa                            880


<210> 345
<211> 4730
<212> DNA
<213> Homo sapiens

<400> 345
ttcagactga cagacttcaa ggatgcagct gctactaccg gaggtgtgtg gcaccttacc       60

tcagcaaggc catgagaccg tgtggccatg atgtgggccc ctcatggcct cagcaggaac      120

acagcactat agtattggcc tccgccagaa aaacagcttc aagcagagtg gtccctcagg      180

cacagtacct gccacgccac ctgagaaacc ctcggagggc agagtctggc ctcaggccca      240

tcagcaagtg aagccaatct ggaagctgga aaagaagcaa gtggagacac tgtcagcagg      300

gttgggccca ggcctcttgg gcgtcccacc ccagccagca tatttctttt gccccagcac      360

tttatgtagc tctgggacca cggctgtcat tgcaggccac agcagttcct gttacctaca      420

ctctctcccg gacttgttca acagcaccct gctataccgc cgctccagct ataggcaaaa      480

accgtaccag caactggagt ctttctgctt gcgttcgagc ccgtcagaaa aaagcccttt      540

ttctctccct caaaagagcc tccctgtcag tctcactgcc aacaaggcca cttcttccat      600

ggtcttctcc atggcccagc ccatggcctc ctcatccaca gaaccatacc tctgcttggc      660

agcggctggg gaaaaccctt cagggaagag cctggcctct gccatctcag ggaagatccc      720

atctccactc tcttcctcct ataagcccat gctgaataat aattccttca tgtggccaaa      780

tagcacgcca gtgcctttat tgcagaccac acagggcctg aagccagtat cgccacccaa      840

gatccagcct gtctcctggc atcattcagg gggtactgga gactgtgcac cgcagcctgt      900

tgaccataag gtgcccaaaa gcattggcac tgtcccagct gatgccagtg cccatatcgc      960

cttgtctacc gctagctccc acgacacatc caccaccagt gttgcctctt cctggtataa     1020

ccggaataac ttagccatga gggcagagcc actttcctgt gctctggatg acagctctga     1080

ttcccaggat ccaactaagg agattcggtt cactgaggcc gtgaggaaat tgaccgcaag     1140

aggctttgag aagatgccga ggcaaggctg ccagcttgaa cagtctagtt tcctgaaccc     1200

cagcttccag tggaatgtcc tcaacaggag caggcggtgg aaacctcctg cggtaaatca     1260

gcagtttcct caggaggatg ctggatcggt caggcgggtc ctccctggtg cctcagatac     1320

cttggggttg gacaatacag tcttctgtac caagcgtatc agcattcacc tccttgcctc     1380

acatgccagt gggctcaatc acaaccctgc ctgtgaatct gtaattgact cctcagcatt     1440

tggagaaggc aaagctccag gtcccccttt tcctcaaact cttggcatag ccaacgtggc     1500

cacccgcctc tcttccatcc agctgggcca gtctgagaag gagagacctg aggaggccag     1560

ggagctggac tcatctgata gggatattag ttcagctact gacctccagc cagatcaggc     1620

tgagactgaa gatacagaag aagaactagt agatggtttg gaagactgtt gtagccgtga     1680

tgagaatgaa gaggaggagg gagactcaga gtgctcctca ttaagtgctg tctcccccag     1740

cgaatcggtg gccatgatct ctagaagctg tatggaaatt ctgaccaaac ccctttccaa     1800

tcatgagaaa gttgtccgac cagccctcat ctacagtctc tttcccaacg ttccccctac     1860

catctatttt ggcactcggg atgagagagt ggagaaactt ccctgggaac agaggaagtt     1920

gctccgatgg aagatgagca cagtgacccc caacattgtc aagcagacca ttggacggtc     1980

ccacttcaaa atcagcaaaa gaaacgatga ctggctgggc tgctggggtc accacatgaa     2040

gtctcctagt ttccgatcca ttcgagagca tcagaagcta aaccatttcc caggctcatt     2100

ccagattggg aggaaggacc ggctatggcg gaacctgtca cgtatgcaga gccgctttgg     2160

caagaaggag ttcagtttct tcccccagtc ctttatcctg ccccaggacg ccaagctcct     2220

gcgcaaagcg tgggagagca gcagccgcca aaagtggatt gtgaagccac cagcatcagc     2280

tcgaggcatt ggcatccagg ttattcacaa gtggagtcag ctccccaagc gaaggcccct     2340

cctggtacag aggtatctac acaaacccta cctcatcagc ggcagcaagt ttgacctgcg     2400

gatctatgtt tatgtcactt cctacgatcc tctgcggatt tacctctttt cagatggact     2460

ggtccgcttt gccagttgca agtattcgcc ttccatgaag agccttggca ataagttcat     2520

gcacctgacc aactacagtg tcaataaaaa gaatgccgag taccaggcca atgcagatga     2580

aatggcttgc cagggccaca aatgggcact gaaggctttg tggaactacc tgagccagaa     2640

gggagtcaat agcgacgcca tctgggagaa gataaaggat gttgttgtca aaactatcat     2700

ctcgtcagag ccctatgtga ccagcctgct caagatgtat gtgcgacggc cctatagctg     2760

ccatgaactc tttggttttg acatcatgct agacgaaaac ctcaagccct gggtcctgga     2820

agtcaacatt tccccaagcc tccactccag ctctccactg gatatcagca tcaaaggcca     2880

gatgattcgt gaccttctga atctggcagg ttttgtcctg cccaatgcag aggatatcat     2940

ttccagcccc agcagctgca gcagctccac caccagcctg cccacctccc ctggggacaa     3000

atgtcgaatg gctccagagc atgtcactgc acagaagatg aagaaagcct attatctgac     3060

ccagaaaatt cctgatcagg acttctatgc atctgtgctg gatgtcctga caccagatga     3120

tgttcggatt ctggttgaga tggaagatga gttttctcgc cgtggtcagt ttgaacgaat     3180

ttttccttct catatctcct ctcgctatct ccgctttttt gagcagccac gatatttcaa     3240

cattctcacc acccaatggg aacagaaata ccatggcaac aagcttaaag gagtagatct     3300

gctccggagt tggtgctaca aagggttcca catgggagtt gtctctgatt ctgctccagt     3360

gtggtctctc ccgacatcac ttctgactat ctcaaaggat gacgtgatac tcaatgcctt     3420

cagcaaatca gagactagca agctgggaaa acaaagctcc tgtgaggtta gcctactact     3480

ctctgaagac gggaccacgc ccaaatccaa gaagactcaa gctggccttt ccccttatcc     3540

ccagaaaccc agttcctcaa aggacagtga ggacaccagc aaagagccca gcctttctac     3600

ccagacgtta cctgtgatca agtgctctgg gcagacttca agactttctg cttcctccac     3660

tttccagtca atcagtgact ccctcctggc tgtgagccca taactggcct ctctccaaaa     3720

gcctctgccc aggagcatgg gcatcagcta cctcacggga accagcctgc tgttcagacc     3780

agtctgaccc cctacccctt tcaccctgtc cctcctcaga gtattttttg aagtggttgc     3840

attatagaga tgggtatttg tagggccgga gggatggtag tgatggggag aaggtgagga     3900

agggtcaccc tctgtcacct gtctgcctgg ctggcacctc atatctcagc agagaagcca     3960

gtggtggcca cgcagcctta taaagcaggt tttggtttct accttaagtg agccatgtgt     4020

ggtttgtctg ggggccctgg tgtggttgct gagttgtagc tcaagaggag aaaacataca     4080

gaacatattt ggaccggaaa tcctttgttc tgaatttgag ggggtcttct gaggtcctta     4140

cttccttagg tctttcctca cccctctccc accgctgtcc tgaggagaaa cccttgaact     4200

tcctcagtag acaggcggag aggccacaac atgccgaacc catttcctgt catcctagtc     4260

ttgggtcttc accgcctcct tccaaatacc caccctgcca gcagccctag gtcttcctgt     4320

tctgaccccc catcactgct cgttcagcct tctagatgtc tctctcgtgg acatctgttc     4380

tttagctgtt ggctttctct gaggtgtgag agggtctatg aactttgtga atttcccatg     4440

gccccagtga aggagcccag ataatcccag tagctgttac ctgtctccat gtatcaaagg     4500

acacagtcca gggggagggt ggaaggagat gtggtttctc tatagtgcaa caaacatggt     4560

ttctcaatgt tctgctgtgc agcaagcagg gtctggcggc ttggtaggtg ggtttcagga     4620

gcagtcacta ttgtaggatg ggcttccaat caaacctcag actaaactct tgtactgaac     4680

tgattctacc tccctcctct agactcagta aacagtgact attcaataaa                4730


<210> 346
<211> 7547
<212> DNA
<213> Homo sapiens

<400> 346
agcagaggcc gagagcggcg agccgcgagc caggcagtcc ggggcatcca gactgcaggc       60

cgcgcccagg ccgcgcccag gctgcgccgc ccgcctgcct cccgcgctgc cgcgtcgcca      120

gtgctagcgc tcctctccag catgctgcgg cggggcagcc aggcgctccg gcgcttctcc      180

actggccggg tttatttcaa aaacaagctg aagttggcac taattggcca gagcctcttt      240

ggacaagaag tctatagcca cctccgcaaa gagggccacc gagtagtagg ggtgttcaca      300

gttccagaca aggatggaaa agctgaccct ctggctttgg ctgcagagaa agatgggacc      360

cctgtgttca agcttcctaa atggagggtc aagggcaaga ccatcaaaga agtggcagaa      420

gcctacagat ccgtgggtgc agagctaaat gtgctccctt tctgcactca gttcattccc      480

atggatataa ttgatagtcc aaagcacggc tctatcattt atcacccatc catcctgccc      540

aggcacagag gagcctctgc tatcaattgg actctaatta tgggagataa gaaagctggg      600

ttttctgttt tctgggctga tgatggcttg gatacaggac ccatccttct tcagagatca      660

tgtgatgttg aacccaatga tacagtggat gcactttata atcggtttct ttttcctgaa      720

ggaatcaagg ccatggtaga agctgtccaa ctcatagctg atggaaaagc tcctcgtata      780

ccccagccag aagaaggggc aacatatgaa ggtatccaga aaaaggaaaa tgctgagatt      840

tcttgggacc agtctgccga agttttacat aactggattc gaggtcatga taaagtccct      900

ggagcttgga cagagataaa tggacagatg gtcactttct atggctcgac attactgaat      960

agctctgtgc ctcctggaga accactggaa attaaaggtg ccaagaagcc tggtctcgtt     1020

accaaaaatg gacttgttct ttttggtaac gatggaaaag cactgacggt gagaaatctg     1080

cagtttgaag atggaaaaat gatccctgcc tctcagtact tttcaacggg tgagacgtca     1140

gtggtagaac tgacagctga agaggtgaaa gtggcagaga ccatcaaggt catctgggct     1200

ggaattttaa gcaatgtccc cattattgaa gactcaacag acttctttaa atctggagca     1260

agctcaatgg atgttgccag gctggttgaa gagatcagac agaaatgtgg tgggcttcag     1320

ttgcagaatg aagatgtcta tatggccacc aagtttgaag gctttatcca aaaggtcgtg     1380

aggaaactga gaggagaaga tcaagaggtg gagctggttg tagattatat ttcaaaggag     1440

gtcaatgaaa tcatggtaaa aatgccatac cagtgtttca taaatggaca gttcacagat     1500

gcagacgatg gaaagactta cgacactatc aacccaacag atggatctac aatatgcaaa     1560

gtatcctacg cttctttggc ggatgttgat aaagcagtag cagcagcaaa agatgctttt     1620

gaaaacggtg aatggggaag aatgaatgca agagaaagag gaagattgat gtatagactt     1680

gcagacctac tggaagagaa ccaagaagag ctggcaacta ttgaagccct tgattcaggg     1740

gctgtctata ccttggccct gaagacacac attggaatgt ctgtgcaaac attcagatat     1800

tttgctggct ggtgcgacaa aattcagggt tctactattc caatcaacca ggcccgtcca     1860

aatcgcaatc tgaccttcac caagaaagag ccactcggtg tctgtgccat tattattccc     1920

tggaactacc cgctgatgat gctggcatgg aagagtgctg cgtgtttggc agcaggcaat     1980

accttagtgc tcaagccagc acaggtcacg cccttgactg ctttgaagtt tgcagaactg     2040

tctgtgaaag caggctttcc aaagggggtc atcaacatca ttccaggctc aggtggcata     2100

gcaggacaac gtctgtctga acatcctgac atccgcaaac ttggtttcac tggatccact     2160

cctattggca aacagatcat gaagagctgt gctgttagca acttgaagaa agtttccctt     2220

gagcttggtg gcaagtctcc acttataata tttaatgact gtgaacttga caaggctgtg     2280

cgaatgggca tgggagcagt atttttcaac aaaggagaga actgtattgc tgctgggcgg     2340

ttgttcgtgg aagaatccat ccacgacgaa tttgtgacaa gagtggtaga agaaattaaa     2400

aagatgaaaa ttggtgatcc acttgacaga tccactgatc atgggcccca aaatcataag     2460

gctcatctgg aaaagctgct gcaatactgt gaaactggag tgaaagaagg ggccactttg     2520

gtgtacgggg gaagacaagt ccaaaggcca ggctttttca tggagccgac cgtgttcaca     2580

gatgtggaag actacatgta cctcgccaaa gaggaatcct ttgggcctat tatggtcatt     2640

tctaaattcc aaaatgggga catcgatgga gtgttgcagc gagcaaatag tacagagtat     2700

ggtttggcct caggggtttt tacaagagac ataaacaaag ctatgtatgt gagtgaaaaa     2760

ctggaagcag gaactgtttt tattaacaca tacaacaaga cagatgtggc ggccccattt     2820

ggcggagtta aacaatctgg ctttggaaaa gacttaggtg aggaagctct aaatgaatat     2880

ctcaaaacca agacggtgac actggaatat tagagcaaca ccatcatcag gaaagccttg     2940

acagacagcc ctttacaact ctggacacac ttaagaagat tgggtgtgtt gaggcaggag     3000

gtgtcagcca caaaccaaaa aatacacaga tggaccatga agagggccag gccatgttaa     3060

agcatttaca catgtgcctg agtattttct aatacacctt ccagtgattt ggagttgttg     3120

cattttgact atgttgtata tcatacgtat ttctaaaata ccaagctgtt tctcccctac     3180

ctagacaaat ctattcatgg ttcccatctt gaagatgtca gtaccatgca gttataatac     3240

acaaggtgca tttattggaa actttgtata atatgtacag gtttttaacc tctgaactat     3300

acataggggg ttattaaaaa gattttctat aagtcttcta aggaacagta taacctgtaa     3360

ggaatgtgaa ggtagttctt ttttagtatt tggaaataag atacatcttt gtgcctttga     3420

tattccattt tttaacccac tgtgatgggt gatcaaccta gaaacattat cttgagtacc     3480

tactaggtac caggtactat attatgttct gaggagtata gagaatttaa tgatatgatg     3540

gctggccccc acatagttta aattttagta aatagctttt gaagcaaatt ttacatatga     3600

tatagtagaa ggctgatcct ggtcgtatca taccatcttc ctatctatgt aactttggga     3660

aactctcgca actcctctga gcctctgctt ccctatgtgt aaaacaggga tagtaaatgc     3720

cttcctcagg acccttaata ggagaattca ttgcagtaat gtaagtaaag cacctcacat     3780

taatgctttg ctcatggtaa gtactcaaat ttaactctga tttcctccgt caccattctt     3840

aaaagatatt gagatagttt aattaactag atgaattcat ttcccacaac ccttttcaat     3900

catcaattcc tagatatttt tctcatccat tgttctgaca caatgcctga tacagcagca     3960

ctgaaaaatg ccacacaatg aaaaatggca atagtacaag gaaaaggggt gcttttcttt     4020

gggcagctcg ctcgtccttc atgggacatc ttactttcca tttttctacc tattggttct     4080

gctgttcact ggctgtgtga tcttgggcaa gatagtaatc taatatctca gagcctaggt     4140

tgagtatcta taaaatgaaa atcaaatctc tatctcagta ggtgttgcaa ggattcagtg     4200

agataatata cataatgcac ttaacaaggc gtttggacca tagcattgaa gaaatggaaa     4260

ctattaacag cccatttccc attggcagac agaagtagtc aggtgagtaa attttcacca     4320

tctatgtgtg actagaaggc ggcaaatttc tgaatcacat gagtctccaa aagatagcca     4380

gaaagttaaa ttctattaat cctcctttaa aaataaaatt tcagtaaaca ttcctttttc     4440

tttggctttg aagaagcctt agggaatatt tgtcattttg gagacttggc agaataacat     4500

gaggggattg tagggaatca ataaaaacta aacaacaaaa tcagagtcag agaacatttt     4560

caaaaggaag aataggaggt ttgatcccag catgataaac agagcgaatt tggcctggaa     4620

gcacttttga ttatactata gctcatttac catcccagag tttggcacag ctgaaatttt     4680

aagttggaat gaatattcac tgggcccaaa atgacagttc atatttgaat aaaagtgaca     4740

aaagcctttt tataagtaat cacttttaag tgaaatgttt taactgattt catgtgattt     4800

agaatatgat ttaatcaaat tattttaatg atagatggaa tggcagacaa aaacatgcct     4860

gtccttctag actgatttta ctttaccctc taatattcat ctcagtagca gtgttttaaa     4920

tattctctgg gctgcaaaac tctttgggaa tctgataaaa gctatgaaca ctccctgtgt     4980

cccgcttcta cccccaaaat tcatgtgcac acacacaatt ctgcaagtat cttcaaaggg     5040

ttcacagacc tcccaaaggc catgcttggg ccccagatta agaactcctt tctccatagc     5100

aagttttaaa catttcttac cagcttacat ttttagatct ggctgatcag aatcaaaggc     5160

tctgtgtaat acataaagtt accaagtgaa ctggaattgg aacatcaccc tccccagcct     5220

gctaggtgat ttacttaaca catagagtaa taaaatcatc gctgttgctt tagatcacgg     5280

attattttgc taataatgct aaggatgaag ctgtgatctt attatcacct gaatcgggag     5340

gtgtggacac tttaagcagt tccactttcc ttctaattcc ccatccccat gcctttgcta     5400

aagctgtccc ttttgctcta acacccttcc tggaccttcc taccctagct gggctaagtg     5460

tttctcctca gcgttcccac ttgtttcaaa catagcactt accacttgta ctaaaattac     5520

ttgccttctt aattagatat gaacaaccct ccccaactcc agtatgggcc ttctgtcaat     5580

aataatacga tatgacagct accatttatt aagggcctcc tgtatgaaag accttaggct     5640

aagcatgttt taaatgttat ttaatcttca caatctctga aaaaaatgaa gaaatcaacg     5700

tgcttttctt actacctcta cccctaagcc attattactt tttttttttt ttgagacaga     5760

gttttgctct tgttgcccag gctgcagtgc agtggtgcaa tcttggctca ctgcaacctc     5820

tgcctcttgg gttcaagcga ttgtcatgcc ttagccttcc aagtagctgg gattacaggt     5880

gtgtgccact acacctggct aagtagagat ggggtttcgc catgttggcc aggctggtct     5940

tgaactcctg acctcaagtg atccacctgc ctccgcctcc caaagtgctg ggattacagg     6000

catgaaccac tgcacctggc ctgttacctc tttcctacaa ttttgctcaa gtctcccaac     6060

tggtcttctg gattcctctc ttctgcggtc ctgttcaaag cttaagtcag acagtgtcac     6120

ttcactcgtc tgtttaaaac ctttcaatgg cccccatttc acgtagacca aagtccaacg     6180

tatttacctg gcctactgat cttgctccta gctacctctg acctcatctc ctgtcaattt     6240

ccctctcatt ctgttccacc atcctgactg ccttgacttc ctcaacagaa caagcctgct     6300

cctgcctcag ggcctctgtc cttattcttc ctcttcccag gggtgtgctg gtaaaatatt     6360

taacaaatag ttctccggga cgggggagaa aaccctcatt tgtagcattt gcaggtatct     6420

atgtgtaaat actctcatca aggctatttt tgagccacta atttgccttc actgaataca     6480

gagtttggga agagatgcat gccatcagaa caaatgcaag ccagcaccag cacaccactg     6540

cctcttcctg caactcttgt ccatacacaa cctcatggct ggctggctca cttcctgcag     6600

gtctctcctc aaatatcatc tgatgagaga cacattccct gactatgctt tctaaaatag     6660

gccatatgcc cccacattca taccccatct gctgtcattc tttattcttt ttataagtgc     6720

attattttca tagcacttat cactacctgt tgtatattaa tcaatgatct tttcccatta     6780

gaatgtaagt ttcatgaaca ggtacttgtt ttaatactgt atctccagtc ctaatgtgta     6840

acaggagccc aataaatgtt tgctttcaaa tggagaggtt aagtaacctg ctcaaatcac     6900

acagctatta agtggcagaa caggttttca agcaatgcat ctggtggttt taactaagtc     6960

gagatagttt ttattcctaa tgcctaaatc agggcctagg tagtgagctg tgggcacata     7020

ttaagtattg gttaaactaa aaataataag caaaatggac attatctata aaagcttttg     7080

tggaaatggc tagagctagg gtaaggaaac aaatttggtt ccccatacct gccctccaag     7140

aaaataaagc tgtcaaggaa aatctgggct aagagtagga tatgagggat gatggataag     7200

gcatgagaca tgagaaataa gggggattaa attattatta ctattataca aatgatgcct     7260

gagtagattt ttaaaatgat taaataccca atgatgtaaa aaacatttat aaaataggaa     7320

agtaagactg actcaaccat aatttgttga gtcaacccaa aaatctattt ggttattttc     7380

aaacagaaat agcctacaga tgatatctga gattgttcca aactttttct atgaatatgt     7440

atactttttt tacataatta acataatact gtatattaat ttgttacctg ctttttcaat     7500

taacaatata tcataagcat ctatgccaat aaacacaatt ctgcata                   7547


<210> 347
<211> 2293
<212> DNA
<213> Homo sapiens

<400> 347
cctgggcatg cgcgagcgcg tcccgggccc ggcgagtcga gggttcaggt ggtgcgccgt       60

ggcgccgcct gcgaccggca gctcgttcgc cgcactttgg aggcttcggc tgcccctccg      120

acccacgtag ggcccggacc cgggcctcct tgtgaacagc gtgccggctt cgccccacgg      180

gttcaccggc tggctgggct tcaagcgccg aggccgccgc agtgaccccg cccccgggcc      240

gaggatgtga ggcgggccgg gcgtccccac accgggcccg ggcgccggga gtgggcgtct      300

gggcagcgcc aggcgatggc cctgctgctg gtgctcctcg cctcttgggg cctggggcag      360

tgagggggcc ggcgggcgtg ggccgagtgg ccgcgggcgc catggagggg gtgctgtaca      420

agtggaccaa ctatctgagc ggttggcagc ctcgatggtt ccttctctgt gggggaatat      480

tgtcctatta tgattctcct gaagatgcct ggaaaggttg caaagggagc atacaaatgg      540

cagtctgtga aattcaagtt cattctgtag ataatacacg catggacctg ataatccctg      600

gggaacagta tttctacctg aaggccagaa gtgtggctga aagacagcgg tggctggtgg      660

ccctgggatc agccaaggct tgcctgactg acagtaggac ccagaaggag aaagagtttg      720

ctgaaaacac tgaaaacttg aaaaccaaaa tgtcagaact aagactctac tgtgacctcc      780

ttgttcagca agtagataaa acaaaagaag tgaccacaac tggtgtgtcc aattctgagg      840

agggaattga tgtgggaact ttgctgaaat caacctgtaa tacttttctg aagaccttgg      900

aagaatgcat gcagatcgca aatgcagcct tcacctctga gctgctctac cgcactccac      960

caggatcacc tcagctggcc atgctcaagt ccagcaagat gaaacatcct attataccaa     1020

ttcataattc attggaaagg caaatggagt tgagcacttg tgaaaatgga tctttaaata     1080

tggaaataaa tggtgaggaa gaaatcctaa tgaaaaataa gaattcctta tatttgaaat     1140

ctgcagagat agactgcagc atatcaagtg aggaaaatac agatgataat ataacagtcc     1200

aaggtgaaat aaggaaggaa gatggaatgg aaaacctgaa aaatcatgac aataacttga     1260

ctcagtctgg atcagactca agttgctctc cggaatgcct ctgggaggaa ggcaaagaag     1320

ttatcccaac tttctttagt accatgaaca caagctttag tgacattgaa cttctggaag     1380

acagtggcat tcccacagaa gcattcttgg catcatgtta tgctgtggtt ccagtattag     1440

acaaacttgg ccctacagtg tttgctcctg ttaagatgga tcttgttgga aatattaaga     1500

aagtaaatca gaagtatata accaacaaag aagagtttac cactctccag aagatagtgc     1560

tgcacgaagt ggaggcggat gtagcccagg ttaggaactc agcgactgaa gccctcttgt     1620

ggctgaagag aggtctcaaa tttttgaagg gatttttgac agaagtgaaa aatggggaga     1680

aggatatcca gacagcccta agaaatccaa cagaaaacac ttgacaccaa aacataccct     1740

gatgaagatc ctgaacttca agaatgaaga aagaattcct caccattcag gcagaaaaag     1800

caagtcacca agggacctca aacttccttt ccacaagatt ctgtgacggg aaacaatggg     1860

ggagtatttc cgaagttctg agtaggaaaa aagaatgact caaatgtatt attgccaacc     1920

aagtcgtcaa atctaatgtc aagttctctt aagcaggtaa gaactcagaa cataatacct     1980

gagtgccttc ttaaggaaac catttgatag gaaagatgaa ccaaataact caatgatgga     2040

tgagctggta gaaaaaaagc tggtggtgaa ccaaggtcaa actggaaatt atagtcacag     2100

tatagatata gattataaat attacaaacc ctaagatagc taataaattg ggaatgggag     2160

aagggaggat ataagagcac taatgccctc ttattttcat agcagagact tgatactgtc     2220

tcaacttttt tcaaaaacac aatttcttaa attttttggt aatcttttaa ataaacagat     2280

ttctaaaaag aaa                                                        2293


<210> 348
<211> 1795
<212> DNA
<213> Homo sapiens

<400> 348
acgtaaccgt tcaagcatcc ctccttccca ggacacactc aaagcgtcag agcggtccgc       60

tcttctcaag tcctattggc tcaagtccat gcgtctcatg gcactgccgg gtgagaggcg      120

gaaaaaggcc ttcccaggcg cgagaagatg acgtcacagt agcccggccg ggcgccgagg      180

ttgccttagg gctctctgcc cagtaacagg catcgaacgg tgcagactga agacgccctc      240

cgtcagcgac gccgtcgcaa tggccatttg tcaattcttc cttcaaggcc ggtgccgctt      300

tggagatcgg tgctggaacg aacatcccgg tgctaggggt gcaggaggag gacggcagca      360

accgcagcag cagccttcag gtaataatag acgtggatgg aatacaacta gccagagata      420

ttccaatgtc atccagccat ccagtttctc caaatccaca ccatgggggg gcagcagaga      480

tcaagaaaag ccatatttca gttcttttga ttctggagct tcaactaaca ggaaggaagg      540

ctttggattg tctgagaacc catttgcttc acttagtcct gatgagcaga aagatgaaaa      600

gaaacttctg gaaggaattg taaaagatat ggaggtttgg gaatcatcag ggcagtggat      660

gttttctgtt tattcaccag tgaaaaagaa acctaatatt tcaggtttta cagacatttc      720

accagaggaa ttgaggcttg aataccataa cttcttaacc agcaataact tacagagtta      780

tctaaattct gtccaacgtt taataaatca atggaggaac agggtaaatg aactgaaaag      840

tctaaatata tcaactaaag tagctttgct ctctgatgta aaggatggag taaatcaagc      900

agcacctgca tttggatttg gcagcagtca agcagcaaca tttatgtcgc caggctttcc      960

agtcaataac agcagcagtg ataatgctca gaactttagt tttaaaacaa actctggatt     1020

tgctgctgcc tcttctggaa gccctgctgg ttttgggagt tccccagcat ttggagctgc     1080

agcctctacc agttcaggta tctctacttc tgctccagct tttggatttg ggaagcctga     1140

agtcacatcg gctgcatcat tttcattcaa aagccctgca gcttccagtt ttggatcacc     1200

tggattttca ggacttccag cttccttggc aacaggtcct gtcagagctc cagtggcccc     1260

agcctttgga ggtggcagtt ctgtggctgg ttttggtagt ccgggctcac attctcacac     1320

tgctttttct aagccatcca gtgacacttt tggaaatagc agcatatcca cttctctgtc     1380

agcctcaagc agcatcattg caacagataa tgtgttattc acacccagag ataaactaac     1440

agtagaagaa ctggaacaat ttcaatccaa gaaatttact ctgggaaaaa ttccattaaa     1500

gcctccacct ctggaacttc taaatgttta aaagggcaat tttaaataca aaaaagaatg     1560

atgtttaaaa ttgctttgag tgattcatac agagatgtat atatgcatac atgtatatat     1620

tcataaggaa tataagcttc catcaatagt gattttaaat ttgatttttt tcttaactct     1680

aaatatttaa gtaaaaagta acaaaaactc tgcaagcaag ggaatttttt tgtactgtaa     1740

ttttgaatgg aactgaaaaa ttatgcacga ataaagtact tttctcatgc catac          1795


<210> 349
<211> 4779
<212> DNA
<213> Homo sapiens

<400> 349
ggtgagagag ggcgtgcgtc tctgtggtta taaagttggg ggtggagtgg ccgggagatg       60

atggctgatg aagaggaaga agtcaagccg atcttgcaga aattgcagga actcgtggat      120

cagctctact catttcgaga ctgctatttc gagacacata gtgttgagga tgctgggagg      180

aagcaacagg atgtgcagaa ggagatggag aaaaccctac agcagatgga agaagtagtg      240

ggttctgtcc agggcaaggc acaagttcta atgctaactg ggaaagcact aaatgtgact      300

cctgactata gccctaaggc tgaggagctt ctgtcaaagg ctgtgaagct ggagcccgag      360

ctggtggaag cctggaacca gctgggtgag gtgtactgga aaaaagggga tgttgcagct      420

gcccacacct gcttctcagg agccctcacc cattgcagga acaaagtctc cttgcaaaac      480

ctgtcaatgg tgcttcgtca gctgcggact gacactgaag atgaacattc tcaccatgtc      540

atggacagtg tccgacaggc taagttggct gttcagatgg atgtccatga tggccgctcc      600

tggtatattc ttgggaattc atatctttcc ctttacttct ctactggcca gaaccctaag      660

atctcccagc aagccctcag tgcctatgcc caagcagaga aagttgacag aaaagcttct      720

agcaatcctg accttcatct gaacagggcg acgttgcata aatatgaaga gagttatggg      780

gaggccctgg agggcttctc tcgggctgca gccctggacc ctgcctggcc agagccccgg      840

caacgagagc aacaacttct ggaattcctg gatagattaa ccagcctcct tgagagtaag      900

ggaaaggtga agaccaaaaa gctgcagagc atgctgggaa gcttgcgccc agcccatcta      960

ggcccttgca gtgatgggca ctatcagtca gcctctgggc agaaagtgac cctggagctc     1020

aagccactga gtacgcttca gcctggggtg aacagcggtg ccgtcatcct gggaaaggtg     1080

gtatttagcc tcaccacaga ggagaaagtc ccctttacat ttggcctggt agattcagat     1140

ggaccttgct atgcagtgat ggtgtacaat atagtgcaga gctggggagt gctcattgga     1200

gactctgtag ccattcctga gcccaacctg cggcttcacc gaattcagca caaaggaaag     1260

gactattcct tttccagtgt tcgagtggag acgcccctcc tgctagtggt gaatgggaag     1320

cctcagggat ccagcagcca ggctgttgcc acagtggcat cgcgaccaca gtgtgaatga     1380

cctttgactt gcatgctcaa cagggagtgg aggagaggag acaaggctct ggacagccgg     1440

tccagccaca tccagtgatt cagcagggat gggaggaatg ttttaaatga agactttctc     1500

tttccctgcc tgtattacac ttcgtatctc ttctctctcc tctgtcctca tcatgttcca     1560

gctctctaca gggccacata ctcttctggc atatctctcc tgtctcttcc actgctctct     1620

atgttttaag caaagagcat ggaattggta gaagtcttgg gatcttgcca tgggacagag     1680

tccccaaggt tcctgttgtt gcctccttcc taagcctcat atgtatatat cagttcagta     1740

tttattgcta aaggaggggg cttaattttg taatggcttt tatttttagc aatttttatt     1800

tttatttttg aactttaggt ccttcctctt ctttggggct ggaacagaat taaatttgtt     1860

tggaaaaaaa aaaaaacacc acgtagtttg gcctgcttta ttctccctag gcctgtattc     1920

tttgttttag gatcacttca atttattgga gtaatacccc catttttttc tttatacaaa     1980

gcagtttatt tctctcccag ttaaaagaat tccgacaata gacagcccca ggcaggaatg     2040

gcaactccac aaagttgcta gagaccagct ttcttccatt ttcccattct gtcattccct     2100

aggggtggtc ttcactatgg tccaagatga cagagcaata ctgttctaat agtgttacta     2160

ggctgaagga ccagagagag ttagataaat cctcagtttc tttagagtct agtgacatgt     2220

tttataacag tttatcttaa tatccttgtg gtaaaatgga gaaatgtgag tgaggattaa     2280

taaccaattg aattggcctg gcacggtggc tcagcctgta atcccaccac tttgggagtc     2340

caaggcgggt ggatcacgag gtcaggagtt caagatcagc ctggccaaga tggtgaaact     2400

ccgtctctac taaaaataca aaaattagct gggcgtggtg gcaggcacct gtaatcacag     2460

ctactgggga ggctgaggca gagaattgct tgaacctggg aagtggaggt tgcagtgagc     2520

cgatatcatg ccactgcact ccagcatggg cgacagagcg agactccgtc tcaaacagca     2580

acaacaactg aatggctgta atacattaat gtatacagat gaattgagaa gtcttctagt     2640

gaaatggctc agatctttgt tcttggtcca gtcctgttca gtttttgatc agtgccttga     2700

atatcattga tgactcatta aatttataaa gagtgcagag gcctcctcag agaatggatg     2760

gtagaaatgc attgatgaga gaagttttat ctatctatct gtctatctat ctatctatct     2820

atctgtctct atctaagaag tcataaaggc tgagtctaat aagataaaat tttcagtcca     2880

ttcttttggt ccaaaaaggc ttacattctc aggtatagct tcaacatcat atatgaatat     2940

tactaagaat cttagtagat aagctaaagt cagtatgagt aaccagtctg atatagtttg     3000

caagaacact cttcatggac tgcaccaaaa aaacctatgg tagcaagaga cagtttttat     3060

tagaagtact gtctgttata ccacatatgg agtcttaaat tagttttggg tgtcattttg     3120

aggcctagag tcatagaaga gtgattagga gcttgtgggg tataaaaata acttgagaat     3180

tggctgaaag caactaggga agatgggggt agtagtatgt gtaaacattt gaggcagtag     3240

agatgtggga cccaaatact gttccccttt tactcaaatt ctgagatgag ttgacatgtt     3300

ctgtgtaggg ctagagagta gaaaaatggc cagtaggtgg tagccacaga gaagcagtgc     3360

gtacaaacaa gtaagtatgc aaaatttgta catacggttt caggaataac tagaataccc     3420

ataaaatatc cacctgcctt aaaaactaga acatcattga taacttggaa gcccttgcat     3480

acctctccat gatctcattt gtcttcacag ctatataaat ctcattgtat gattatacca     3540

taatttattc atcctgttgt taaaggatat ttgggtttcc agtttttctt tttttactac     3600

caaagcacta cattattaat attcttgtat atgtcctgat atgtaagtgc aaaagtttct     3660

tttacagcaa tggctcttga agagtggttc ccagaccagc agcatcagca tcccttggaa     3720

cttctttgaa atgcaaattc tcaagccccc tacccagact tactgaattc aaaactatgt     3780

gggaggagcc cagcaatctg tgtttcgcaa accctccagg tgactctgat gcacagtaaa     3840

atttgagaac cactgtttaa gagtattgac atagaatgga attgctggat catagagtat     3900

atacatgttc aacttttttg agaagcacta aacatttcca aagtgcttat attagtttat     3960

gtctctacta tcaatagatg agtcacccca atgctcccca tcctcttctg tgcttggtat     4020

tatcttttag gtattgcaaa tacaggagat ttgagtatta tttccttgtg gccttaattt     4080

gcatttctga ttattaatga gcttgagcat cttttcatat atttagaagc cactaatatt     4140

ttctctcggt aaaatgccta ttcgagtctt tgcacactgc tgtattggat gtcaaattga     4200

tttatatatt ccctgtacta atcgtttgtc tacatacagt tttatcctgt tttttttttt     4260

attctattgg gtcttttgct gaacagaagt tcttaatttc aatgtcattg aatttatcca     4320

tcttttatga taatgctttt tgtgttttaa gaggttctta gctctcctaa agtcataagg     4380

acattttccc tctactgctt tatgaagtta ttttgtcctt ttcttacagt atgactttat     4440

tttatgttat gtacggatat aatttttttc ataatgagta aatagcccag caccttttat     4500

taaagaatca atcctttccc tactgatctt taaagcccag tctgtctttt tctttttttg     4560

aaattgtcta gctttttaat ttttaccaac cagatgatta taaaatatca catagtaggc     4620

ataaattaca tttctttgtc cattcctgtt tctttttcta tgaaatctct gttttctttt     4680

gtccaatttt tattgggttg tcttcttatt gattccttac atgttctgga tactaatcca     4740

ttataaatta tgtttttcaa atatatttat ccaaatcgc                            4779


<210> 350
<211> 3682
<212> DNA
<213> Homo sapiens

<400> 350
caggcgggac gggctctccc ttgggtgctt agccccgccc ccgtcccact ctgccctgtt       60

gctgtcgcgc cgctgctggt tgctgtccct ggacccctac catggaggag accatcaaag      120

atccccccac atcagctgtc ttgctggatc actgtcattt ctctcaggtc atctttaaca      180

gtgtggagaa gttctacatc cctggagggg acgtcacatg tcattatacc ttcacccagc      240

atttcatccc tcgtcgaaag gattggattg gcatctttag agtggggtgg aagacaaccc      300

gtgagtatta caccttcatg tgggttactt tgcccattga cctaaacaac aaatcagcta      360

aacagcagga agtccaattc aaagcttact acctgcccaa ggatgatgag tattaccagt      420

tctgctatgt ggatgaggat ggtgtggtcc ggggagcaag tattcctttc caattccgtc      480

cagaaaatga ggaagacatc ctggttgtta ccactcaggg agaggtggaa gagattgagc      540

agcacaacaa ggagctttgc aaagaaaacc aggagctgaa ggacagctgt atcagcctcc      600

agaagcagaa ctcagacatg caggctgagc tccaaaagaa gcaggaggag ctagaaaccc      660

tacagagcat caataagaag ttggaactga aagtgaaaga acagaaggac tattgggaga      720

cagagctgct tcaactgaaa gaacaaaacc agaagatgtc ctcagaaaat gagaagatgg      780

gaatcagagt ggatcagctt caggcccagc tgtcaactca agagaaagaa atggagaagc      840

ttgttcaggg agatcaagat aagacagagc agttagagca gctgaaaaag gaaaatgacc      900

acctctttct cagtttaact gaacagagga aggaccagaa gaagctcgag cagacagtgg      960

agcaaatgaa gcagaatgaa actactgcaa tgaagaaaca acaggaatta atggatgaaa     1020

actttgacct gtcaaaaaga ctgagtgaga acgaaattat atgtaatgct ctgcagagac     1080

agaaagagag attggaagga gaaaatgatc ttttgaagag ggagaacagc agattgctca     1140

gttacatggg tctggatttt aattctttgc cgtatcaagt acctacttca gatgaaggag     1200

gcgcaagaca aaatccagga cttgcctatg gaaacccata ttctggtatc caagaaagtt     1260

cttcccccag cccgctctcc atcaagaaat gccctatctg caaagcagat gatatttgtg     1320

atcacacctt ggagcaacag cagatgcagc ccctttgttt caattgtcca atttgtgaca     1380

agatcttccc agctacagag aagcagatct ttgaagacca cgtgttctgc cactctctct     1440

gagtatccca acctcttgga tgtatacaga gattttatag aatagaacct atagcttcta     1500

ccatgagtta tatgagtcaa gatcctgcct aacctgaaat tattagggat ttactcagcc     1560

ctgctgccgc taacagtgga gttatgtcac tgatctgaag gtcactgtta agggcttctg     1620

ctgccatcct tgtgggttgc tacctttaag tcgcataact ctagctgtat catcctctca     1680

cctgtcattc ttctgagggt ctcagtacaa gggccctggg atggagccaa cctgggtatt     1740

cacaacaggc ctgacttgat actaagtgat tagttttcca agttgtccca ctgccattca     1800

aagtcagccc ttgagtgtat ttgttctcag tcctaaccct ggggccagag attggtccga     1860

ggttgagaat tccttcctcc tcatccttgg tgttgctttc tccaaatgat tgttttagac     1920

tagccaaaaa tgccgtggca aagagctcag aaatccaatt tggataccaa aggtttctca     1980

tgttaatttc tcagccccca aagaagcatc ttactcctga accttagaca ggaagtattg     2040

tttcagtcac agaaagcttt tctgggtacc tctggttagc actttctact ctctgatatt     2100

tcctatgtac atagctttta ttgttgtaaa tcctttctta atggttaaat aggattgtta     2160

gcaactatgg gtttgcagtt ttctgagtag gtgagttttg aatatgggta aatcagaata     2220

atgagacaac ttgttaatct ctttaatact aaaaataaat tactcttcta tttcagggac     2280

ttaggtaatt taaaataaac cttcaattta tggtcttctg ttttgaagct catgggaaaa     2340

ttgtgatcaa aagggctatg ggaagggcag accccgccaa tgatttctct tcacctgtct     2400

taagattaaa taaaaaagag tgtcctggca gttatcttga ggtggggaag gaggtgatga     2460

aacattagtt tgtgaaatcc aaggccctgg cttgctttct ttcttttttt tttttttttt     2520

ttgaaacagt ctctctctgt cacccaggct ggcgtgcaat ggcgcagttg actcactaca     2580

gcctctgcct cccaggttca agcgattctc atgccttagc ctcccaagta gctgggatta     2640

caggtgtgtg ccgcaatgcc cagctaattt ttgtgttttt agtagagaca gggtttcact     2700

atgttggcca ggctggtctc gaactcctgg cctcacgtga tctgtccact tcagccgtcc     2760

aaagtgctgg gattacaagc gtgagccact gtgctgggcc cgaggccctg acttcttgct     2820

gtaactttcc atgcattttt tttaaaagga gcagtgtgga ttttcgcacc ctttgtgaac     2880

taagttcaat gcgctctatc caaatttgcc taattgaact ataagaaagt aataattcca     2940

ttttctatcc cctcagggac tgaacaaatg gaaataactc ccaggcagta tcaggtggtc     3000

actacagaga cttccacaaa aacttttgaa tgatgtgaaa cacgatgtca tgaataaggg     3060

ttgagccaac tatagctctg tgttcctact gggctttccc taatgtggtt gggagttatg     3120

ccctagacta actgtattgt cctagtcaca gctccttgct ttgatttcat ccttgataaa     3180

atgaagatga aacttacact acttctccaa gccttttgct gtcttaagaa taagacctga     3240

gattaacact aaccctagaa tagaaatgta atagggagat ggtaataaag gagtttttct     3300

ggcacatacc ctccctacag aatttctgtt gctccccaga tccagtgaag aattgcagtt     3360

tcatttattt tgtaccagtc agctcttaat taagtacatg aatggagagg aacagtggtg     3420

cacataatcc aaatcagtga ataccatttt ctggtgaatt acccacccct ttgcccctgc     3480

taccccgagg gttaccatga ttgtcaacag cagcaggagc ccttccacag ggcttggtaa     3540

aaaaaccagt tgaggtgtta atgacccttt ttgctgggtg taaaacaaag catctttaac     3600

cactgttcat tatccccagc tgctcttacc aaggctttga agggggaaat tatgctctag     3660

gcagccacta gtagtaaaca at                                              3682


<210> 351
<211> 2528
<212> DNA
<213> Homo sapiens

<400> 351
ctcttccttc cgccggctgc gcactcacag tgatccctgc gcgcgtctcc tgctcgggtc       60

agtgcgccgc gctgcgctgg gcgccatggc gctccccgga gcccgggctc gcggctgggc      120

ggcagcagcc agagcggccc agaggcgccg ccgcgtggag aacgcaggag ggtccccgag      180

tcctgagcct gcgggccggc gcgcggcgct ttacgtacac tggccttact gcgagaagcg      240

ctgcagttac tgcaacttca acaagtacat ccctcgccgc ctggaggagg ctgccatgca      300

gaagtgtctg gtgaccgaag ctcagacgct gctgcggctc agcggggtgc aacgggtgga      360

gtctgtgttc tttggtgggg ggacccccag tctagccagt ccccacacgg tggctgctgt      420

cctggaggct gtggcacagg cagcccacct gcctgcagac ttggaagtca cattggaggc      480

taatcctact tcagctccgg gctccagact ggcagagttc ggggcagcag gggttaacag      540

gttgtctata ggcctccagt ccctagatga cactgagctc cggctgttgg gacggacgca      600

ctcggcctgc gatgctctgc ggacgctggc agaggcccgg cgcctctttc ccgggcgcgt      660

gtctgtagac ttgatgctgg ggctgccggc acagcaggtg gggccgtggc ttgggcagct      720

gcaggaactg ctgcaccact gtgatgacca cctctccctc taccagctgt ccctggagcg      780

gggcaccgca ctcttcgccc aggtgcagcg gggtgccctt ccagcccctg acccggagct      840

cgcagctgag atgtaccaga ggggccgggc tgtccttcgg gaggctggct tccaccagta      900

tgaggtctcc aactttgccc ggaatggggc gctcagtacc cacaattgga cttactggca      960

gtgtggtcag taccttggcg ttgggcctgg ggcccatgga cgatttatgc cccagggggc     1020

tggaggccac acccgggagg ctcggatcca gacactggag cctgacaact ggatgaagga     1080

ggtgatgctg tttggccatg gcacccggaa gcgtgtcccc ctgggcaggc tggagctgct     1140

ggaggaagtt ttggccctgg ggctacgcac cgatgtgggg atcactcacc agcactggca     1200

gcagtttgag ccccagctga ccctgtggga tgtgtttgga gcgaacaagg aggtgcagga     1260

gctgctggag cggggcctac tgcagctgga tcacaggggt cttcggtgtt cctgggaggg     1320

tctggctgtg ctggactctc tcttgctgac cctcctgcct cagctccaag aagcctggca     1380

gcagagaacc ccctcccctg tgccaggagg atgacaaaaa tgttcctgtg ttccagggta     1440

atgccaggtg ggttttgaga gctgggtcgg tactgcagac atctcttctc cgttgtcggg     1500

tgccgtctct gctccttgtg gttattgctc agccctggca tccccagggg aatggcagca     1560

gtgaggtaga tgggaggaca tttctggtca gggaactggc atcccattca gcatctcagg     1620

actcacaggc caacatgtgt tccatggctg ggaattgcct accacccaca tcagcttctg     1680

tttacctttt tggcatcaaa taatgaacag tgtttggaaa tctttctaca ggcaattacc     1740

tccccaagag aagccttcct tattttggag taaggtccta agatagctgg atgaatcagg     1800

aaaaccatgt cccctctagg tattattaat ataagcagga agggatctac tataggaatg     1860

aagtatttat aaaccactga aagggataga gaagtgaaca ttggagaaag ccagtagcaa     1920

ctgtgagaaa tcagcaactt gcaggaggca cagaaaactc ctgctgatgg tctcagcttc     1980

cagcagcaca aaagcagatg atgtactgga aaatgctcag aagatgctac aaaacctcat     2040

gcctactgtc tgccactgct ggagaaggaa tcatggtttc tagaagtgcc tctcattagt     2100

ggactttaaa gcaaatcctg gctggcagga aattctgagg aatatagctc ttaggcttcc     2160

agcctctacc atgcaggaga gaacacagaa ggactgatgt atgttggtgg atccatgtat     2220

gtgtccagca cagcggcctg ctggactctg agaactggga aagatcagag caagccttgc     2280

ctcttatctt cgggaaacca gaatatgttt ggggtggtag gagccacaca gactcttctg     2340

agccccctca ctcacttcct tccccctgtg cctttccttt gagagtgaag gtgggtggag     2400

ttgaccagag aaaggggaga gaattcggga aagacccaaa gtgtttgtaa ttcttctttg     2460

tccttttacc tacagaaatg gtcacatggt tctatttaaa tagcctaata aacacatctg     2520

gagcctgt                                                              2528


<210> 352
<211> 2152
<212> DNA
<213> Homo sapiens

<400> 352
tttctcagtg gaagttccca cttcaacata agggagagct ctggacagtt tgagcagcat       60

tgttagagcc tgtggaaaac actttacaac tgtgtaactg tcttcatctt tacagaggaa      120

tagtctacaa aggaagactt gtaacctgga gaagagacct gtcatttact ccatccttta      180

tagtgatgct acaggacgaa gaggaatgga taaaaacatt ggcgagcaac tcaataaagc      240

gtatgaagcc ttccggcagg catgcatgga tagagattct gcagtaaaag aattacagca      300

aaagactgag aactatgagc agagaatacg tgaacaacag gaacagctgt cacttcaaca      360

gactattatt gacaagctaa aatctcagtt acttcttgtg aattccactc aagataacaa      420

ttatggctgt gttcctctgc ttgaagacag tgaaacaaga aagaataatt tgactcttga      480

tcagccacaa gataaagtga tttcaggaat agcaagagaa aaactaccaa aggtaagaag      540

acaagaggtt tcttctccta gaaaagaaac ttcagcaagg agtcttggca gtcctttgct      600

ccatgaaagg ggtaatatag agaagacttt ctgggatctg aaagaagaat ttcataaaat      660

atgcatgcta gcaaaagcac agaaagacca cttaagcaaa cttaatatac cagacactgc      720

aactgaaaca cagtgctctg tgcctataca gtgtacggat aaaacagata aacaagaagc      780

gctgtttaag cctcaggcta aagatgatat aaatagaggt gcaccatcca tcacatctgt      840

cacaccaaga ggactgtgca gagatgagga agacacctct tttgaatcac tttctaaatt      900

caatgtcaag tttccaccta tggacaatga ctcaactttc ttacatagca ctccagagag      960

acccggcatc cttagtcctg ccacgtctga ggcagtgtgc caagagaaat ttaatatgga     1020

gttcagagac aacccaggga actttgttaa aacagaagaa actttatttg aaattcaggg     1080

aattgacccc atagcttcag ctatacaaaa ccttaaaaca actgacaaaa caaagccctc     1140

aaatctcgta aacacttgta tcaggacaac tctggataga gctgcgtgtt tgccacctgg     1200

agaccataat gcattatatg taaatagctt cccacttctg gacccatctg atgcaccttt     1260

tccctcactc gattccccgg gaaaagcaat ccgaggacca cagcagccca tttggaagcc     1320

ctttcctaat caagacagtg actcggtggt actaagtggc acagactcag aactgcatat     1380

acctcgagta tgtgaattct gtcaagcagt tttcccacca tccattacat ccagggggga     1440

tttccttcgg catcttaatt cacacttcaa tggagagact taagacacat ttgaaaacag     1500

acatatcaag ttctatgtga tgattttggg tttttaatac tataaatact tgattgtaaa     1560

ctaaattcaa gatcatttat aggaaaatct agtttcacag ctatttgaat ttttttctgg     1620

atttactata taactcttat tttttaaaag atcattctgt tctttcaagg agaaataagc     1680

ctaaaagaag aaaaacaaaa aaaattctgt ataaaactgt aatcctttgt attcatgttt     1740

acagtgctat tactataatt caaaattatg tatgtgactt agagttatat aatcataatt     1800

tatgtttatt tcaaatatct aagtttattg cttggatttc tagtgagagc tgttgaattt     1860

ggtgatgtca aatgtttcta gggttttttt agtttgtttt tattgaaaaa tttaattatt     1920

tatgctatag gtgatattct ctttgaataa acctataata gaaaatagca gacaacataa     1980

acatctttgt aaatatcaaa cctaatacat ttcttgtcca gtgataaaac aactggtaga     2040

attatttaaa cactttagat ttttaaataa tatacatggc tttaattttt actgtgtgta     2100

tagctacatg atgaaattaa ttaaatatta agaggtactt atgttgtgat ca             2152


<210> 353
<211> 3057
<212> DNA
<213> Homo sapiens

<400> 353
gagcgggcga gcggcgacgg cggcggcggc gggcacagat taattaaaag aagaatgaac       60

tataatcctt gaagataact gggcaatttt ttaagtcgga ggctgttctt actggtgtga      120

ggatttacac acgtcttcag tttttcagca cagaccagca gaccatcatt tttagaggaa      180

atactccctc tgccctcctt tttggtttcc ttggtggtaa agattaaatt tggttgcatc      240

attttgactt gtgtttgagt ctagatttta tggcacaagg aatggcataa acttttcatg      300

tgttttggtt aaaacaaacc agaccattgc attgaccctg gacatcttta attgagaaat      360

tggtaacttt attttaatat gtatatctga agaattcaag aaaacaaagg catcctcaga      420

ggtgtgcctc ttttctttat tattagaggc aaaacgaaca attttatagg atttgtagtg      480

aaattatacc agattataag gagaaccaaa actaagtcgc aaaatttatt aatttaaggg      540

gctctcgctt tgaaagtttg agagtaagtt acgataggca tttgtatcca ttcattactt      600

tcctcttttc aaataagcaa ctaaatagaa atgctaatct cagacttaat tatttaacag      660

aagagtgtac catggaaaac ctccagacaa atttctcctt ggttcagggc tcaactaaaa      720

aactgaatgg gatgggagat gatggcagcc ccccagcgaa aaaaatgata acggacattc      780

atgcaaatgg aaaaacgata aacaaggtgc caacagttaa gaaggaacac ttggatgact      840

atggagaagc accagtggaa actgatggag agcatgttaa gcgaacctgt acttctgttc      900

ctgaaacttt gcatttaaat cccagtttga aacacacatt ggcacaattc catttaagta      960

gtcagagctc gctgggtgga ccagcagcat tttctgctcg gcattcccaa gaaagcatgt     1020

cgcctactgt atttctgcct cttccatcac ctcaggttct tcctggccca ttgctcatcc     1080

cttcagatag ctccacagaa ctcactcaga ctgtgttgga aggggaatct atttcttgtt     1140

ttcaagttgg aggagaaaag agactctgtt tgccccaagt cttaaattct gttctccgag     1200

aatttacact ccagcaaata aatacagtgt gtgatgaact gtacatatat tgttcaaggt     1260

gtacttcaga ccagcttcat atcttaaagg tactgggcat acttccattc aatgccccat     1320

cctgtgggct gattacatta actgatgcac aaagattatg taatgcttta ttgcggccac     1380

gaacttttcc tcaaaatggt agcgtacttc ctgctaaaag ctcattggcc cagttaaagg     1440

aaactggcag tgcctttgaa gtggagcatg aatgcctagg caaatgtcag ggtttatttg     1500

caccccagtt ttatgttcag cctgatgctc cgtgtattca atgtctggag tgttgtggaa     1560

tgtttgcacc ccagacgttt gtgatgcatt ctcacagatc acctgacaaa agaacttgcc     1620

actggggctt tgaatcagct aaatggcatt gctatcttca tgtgaaccaa aaatacttag     1680

gaacacctga agaaaagaaa ctgaagataa ttttagaaga aatgaaggag aagtttagca     1740

tgagaagtgg aaagagaaat caatccaaga cagatgcacc atcaggaatg gaattacagt     1800

catggtatcc tgttataaag caggaaggtg accatgtttc tcagacacat tcatttttac     1860

accccagcta ctacttatac atgtgtgata aagtggttgc cccaaatgtg tcacttactt     1920

ctgctgtatc ccagtctaaa gagctcacaa agacagaggc aagtaagtcc atatcaagac     1980

agtcagagaa ggctcacagt agtggtaaac ttcaaaaaac agtgtcttat ccagatgtct     2040

cacttgagga acaggagaaa atggatttaa aaacaagtag agaattatgt agccgtttag     2100

atgcatcaat ctcaaataat tctacaagta aaaggaaatc tgagtctgcc acttgcaact     2160

tagtcagaga cataaacaaa gtgggaattg gccttgttgc tgccgcttca tctccgcttc     2220

ttgtgaaaga tgtcatttgt gaggatgata agggaaaaat catggaagaa gtaatgagaa     2280

cttatttaaa acaacaggaa aaactaaact tgattttgca aaagaagcaa caacttcaga     2340

tggaagtaaa aatgttgagt agttcaaaat ctatgaagga actcactgaa gaacagcaga     2400

atttacagaa agagcttgaa tctttgcaga atgaacatgc tcaaagaatg gaagaatttt     2460

atgttgaaca gaaagactta gagaaaaaat tggagcagat aatgaagcaa aaatgtacct     2520

gtgactcaaa tttagaaaaa gacaaagagg ctgaatatgc aggacagttg gcagaactga     2580

ggcagagatt ggaccatgct gaggccgata ggcaagaact ccaagatgaa ctcagacagg     2640

aacgggaagc aagacagaag ttagagatga tgataaaaga gctaaagctg caaattctga     2700

aatcatcaaa gactgctaaa gaatagaaac tgttaaagag attcatctgt gtattactga     2760

caaggttttt tttgtttgtt gcttgctttg gtaattgaat tctgaagaat ttatctgcat     2820

gacgataact aggcattcta tccatttgta gatcagagaa agtgaagaga ttatatatta     2880

gtacttaaat ttttacattt tccaaatgaa tgaaaatgta tgtttctttg tactttttta     2940

aaaaaatcag cttagtaaca atactatatg gtttcaacta gtaggtaatc tgcttatatt     3000

tctaatgcaa acttaacaat tgtgtacttt ttaaaagctg caatatgtgt tggaaaa        3057


<210> 354
<211> 2849
<212> DNA
<213> Homo sapiens

<400> 354
agctcccgcc cgcccgcggc cgcccgggag ctcgtccagc cccgcgctgc gctcgcccgc       60

ccgctgcccg ccggagcacc gcggcctccg cccgcgtcca tctgcccgcc gcccgcgcct      120

gttccgcagc ccgcgtccgc gccggcccca cagctctgcg tccgggtatt actcagcaca      180

gaaattcagg agacacagac aagttcttcc acgatgtcgt acagacgaga actagagaaa      240

taccgtgacc tggatgaaga tgaaatcctt ggagccctaa cagaggaaga gctgaggacc      300

ctggaaaatg agctggatga gctggaccct gataatgcac tgctgcctgc aggcctgagg      360

cagaaggatc agaccaccaa ggcgcccacg ggccccttta aaagagagga gctcttggat      420

cacttggaaa agcaagcaaa ggagtttaag gaccgagaag atctggtccc ctacacaggg      480

gaaaaacgag gaaaggtctg ggttcctaag cagaagccac tggatcctgt gctggaaagt      540

gtgacgctgg aaccggagct ggaggaagcc ttggcaaatg cttcagatgc agaactctgt      600

gacattgcag cgatcctggg catgcacacg ctcatgagta accagcagta ctaccaggcc      660

ctgagcagca gctccatcat gaacaaggag gggctcaaca gcgtgattaa acccacacaa      720

tacaagcctg tgcccgacga agaaccaaat tcaacagacg tagaggaaac gctggaacgg      780

ataaagaaca acgacccaaa acttgaagaa gttaacctca ataatatccg gaatatcccc      840

atccccaccc tcaaggcata tgcagaagcc ctgaaagaaa actcatatgt gaagaagttc      900

agcatcgtgg ggacacggag taatgacccc gtggcgtatg cccttgctga gatgctcaag      960

gagaacaagg tgttgaagac actgaatgtg gaatccaact tcatttctgg agctgggatt     1020

ctgcgcctgg tagaagccct cccatacaac acttctctgg tggaaatgaa aattgacaac     1080

cagagccagc ccctgggcaa caaagtggaa atggagattg tgagcatgtt ggaaaaaaac     1140

gcaacacttc tcaaattcgg ctaccacttt acccagcaag gaccccggct tcgggcatcc     1200

aacgcaatga tgaacaacaa tgaccttgtg aggaagagga ggcttgcgga cctgactggg     1260

cccatcattc ccaagtgccg gagtggtgtc tagtgtgtgg cggtggagtc catgcctttg     1320

aactggatgt gttctattga tgacctgtgc tctgcagggg aaaccagaag gcaaaatgct     1380

ggcagcatga aacccttttg tggttcagtt ctttatgcac taaggtttta ggttgactag     1440

tggttgtagt tgaaaatttt ataaaatacc gttaatgtga agtttttctt tagtcacaga     1500

agttgaatct ggttattatt taaaaactag aagcccccaa accagcagat cttactgaag     1560

atgatgttcc agcagcagcg acttagcccc aggagcccag tttcaatggc cttgctgtgt     1620

ggtgtttcaa gtgcatttaa aatgtgtgac acagaaacgg cacactcttc cacatgcttt     1680

tgaagtatta taaaacactt tattacaaat ttgtcttagc tattagcaaa taaaactgat     1740

tatcattctt tattaaccct ccttggaatt ttgaaaacct cgattaaagt tgccaaattg     1800

attactggat ccagaacaca attttcccct cagaacagat agacagactg aagccactga     1860

actctgccag gagtcaacat gagattcctt ttgctggata tgcagaaatg ataggaaaaa     1920

aaccaatggt gaaatttcaa gtttcaaaaa ccaacctttc attaccaatc ccaggcaaca     1980

aacatgtccc tgagtgttct ttaagaacat ttgggattta tgtacaattt aatactggag     2040

ttagaacttt ttccttattg aatgccaacc ttatgatgga tgtgaaaatc tacggccaaa     2100

tacttttgaa aacacctttc tatattgcac agtgggcaaa tggcttatgt gaggtaagac     2160

actagaggga taaatttcca gatcaacatg gctatggtat ttagtaatgg cccagcttag     2220

agacttcagc tactgatctc atcacttatt agacaaattg ctgctgacct tacgcctgta     2280

tattaagcct ccgcaggatg ccggacaatg gtgaagaaac tccagatatc aaggaattgg     2340

gaaatcctgg ccaaaccacc ccaagatgat tacactgaaa tgtagtatta gtactgctgc     2400

cagatctctt tttaacatca tgtgcgtctc ttgggatcca gcaaaagtgt taagccacaa     2460

tgcccttgtg ccttttaata taccacagtg ccagttaaac taatattttt gtttgttgct     2520

tttgggagtt attttcatta gtgatttcag caaatctcat gataaaggac aaggtcaaga     2580

actccagagc actgagcaga gaggctggtg atgaaaaggt gaaggcctgc gcactgaact     2640

gtaaggcagt gggcagtaca gggtaactgg aggcggggcc agggcctcag cgctatggaa     2700

gagtgtccac tgaggctgca catggcccag gagtggcacc atgttgcagg gacaaccatc     2760

cccatttggc ttctccttaa aacacaattg cagctgcatt ctgcatcgct gaaaactgca     2820

atataatatt aaatctgttg gtctatgca                                       2849


<210> 355
<211> 2179
<212> DNA
<213> Homo sapiens

<400> 355
tgtgcagagc aggacatgga agaacgcggg tcacccgacg gggatctcgc gcggagcctg       60

gagcaagggc cagaggggcc ggaaacgccc atccaggtgg tgctcagggt acgtcccatg      120

agcgcggccg agctgcgtcg agggcagcag agcgtgctgc actgctcagg gacccggact      180

ctgcaggggg gtccagaagt ggcgttccgc ttcggtgcgg tgctagacgc ggcgcgcacg      240

caggaggacg tgttccgggc gtgcggcgtg cggcgcctgg gggagctggc gctgcgcggt      300

ttctcctgca ctgttttcac ctttggccag acgggctctg ggaagaccta caccctgact      360

ggaccccctc cccaggggga gggggtgcct gtacccccca gcctggctgg catcatgcag      420

aggaccttcg cctggctgtt ggaccgcgtg cagcacctgg gtgcccctgt cacccttcgc      480

gcctcttatc tggagatcta caatgagcag gttcgggact tgctgagcct ggggtctccc      540

cggcccctcc ctgttcgctg gaacaagact cggggcttct atgtggagca gctgcgggtg      600

gtggaatttg ggagtctgga ggccctgatg gaacttttgc aaacgggtct cagccgtcga      660

aggaactcag cccacaccct gaaccaggcc tccagccgaa gccatgccct gctcaccctt      720

tacatcagcc gtcaaactgc ccagcagatg ccttctgtgg accctgggga gccccctgtt      780

ggtgggaagc tgtgctttgt ggacctggca ggcagtgaga aggtagcagc cacgggatcc      840

cgtggggagc tgatgcttga ggctaacagc atcaaccgaa gcctgctggc cctgggtcac      900

tgcatctccc tgctgctgga cccacagcgg aagcagagcc acatcccttt ccgggacagc      960

aagctcacca agttgctggc agactcactg ggagggcgcg gggtcaccct catggtggcc     1020

tgcgtgtccc cctcagccca gtgccttcct gagactctca gcaccctgcg atatgcaagc     1080

cgagctcagc gggtcaccac ccgaccacag gcccccaagt ctcctgtggc aaagcagccc     1140

cagcgtttgg agacagagat gctgcagctc caggaggaga accgtcgcct gcagttccag     1200

ctggaccaaa tggactgcaa ggcctcaggg ctcagtggag cccgggtggc ctgggcccag     1260

cggaacctgt acgggatgct acaggagttc atgctagaga atgagaggct caggaaagaa     1320

aagagccagc tgcagaatag ccgagacctg gcccagaatg agcagcgcat cctggcccag     1380

caggtccatg cactagagag gcgtctcctc tctgcctgct accatcacca gcagggtcct     1440

ggcctgaccc caccgtgtcc ctgcttgatg gccccagctc ccccttgcca tgcactgcca     1500

cccctctact cctgcccctg ctgccacatc tgcccactgt gtcgagtgcc cctggcccac     1560

tgggcctgcc tgccagggga gcaccacctg ccccaggtgt tggaccctga ggcctcaggt     1620

ggcaggcccc catctgcccg gcccccaccc tgggcacccc catgcagccc tggctctgcc     1680

aagtgcccaa gagagaggag tcacagtgac tggactcaga cccgagtcct ggcagagatg     1740

ttgacggagg aggaggtggt accttctgca cctcccctgc ctgtgaggcc cccgaagaca     1800

tcaccagggc tcagaggtgg ggccggggtt ccaaacctgg cccagagact ggaggccctc     1860

agagaccaga ttggcagctc cctgcgacgt ggccgcagcc agccaccctg cagtgagggc     1920

gcacggagcc caggccaagt cctccctccc cattgaaggc caagtgggaa cccaggagac     1980

tgctgtgtga cctcagactg ggctccacac tcttgggctt cagtctgccc atctgctgaa     2040

tggagacagc agctgctact ccacctgcag ctgggctagg ggcggggact gggggtgcta     2100

tttaggggaa caaggggatt caggagaaac caggcagcag gggatgaaat acatgaataa     2160

agagaggcat cagctccaa                                                  2179


<210> 356
<211> 1325
<212> DNA
<213> Homo sapiens

<400> 356
gcccccgagc aggagccggt gcgagcggag cagagccgag gtcgggccgc gagcggagcc       60

ggctgagcgg gcgccgagct cccgccatgg cccggaacac gctgtcctcg cgcttccgcc      120

gggtggacat cgacgaattt gacgagaaca aatttgtgga cgagcaggag gaggcggcgg      180

cggcggcggc ggagccaggc ccggacccga gcgaggtgga cgggctcctg cggcaagggg      240

acatgcttcg ggcattccat gcagccttgc ggaactctcc cgtcaacacc aagaatcaag      300

ctgtgaagga gcgagcccag ggcgtggtgc tgaaagtgct cacaaacttc aagagcagtg      360

agattgagca ggctgtgcag tcactggaca gaaacggcgt tgacttgtta atgaagtaca      420

tttataaagg ctttgagaag cccacagaaa atagcagcgc agtgttactc cagtggcacg      480

aaaaggcctt agcagtagga ggactaggct ccattataag agttcttaca gcaagaaaga      540

ctgtttaaaa aaaataaaaa gactcatgtt accttgagaa gaattctgga tgcccaggct      600

ggtgaagaag ggattgacaa tggaccatct tcctaggaac tcccaagtaa actatttcag      660

gacatgtatc tgctgaaatg tattttattt tcaaggtgga ggggaaaatc gtctgtttcc      720

taaatcctgt ttaggatctg atagtctatg cctttgtctc cgagtactgc agaactgaca      780

ttttgacggt ctaccagcgt ggcggctggt gttggtcaga tgcacctgtg tgcactgggg      840

gagggatggt ttgggcaggt gcagatccaa gggctgtggt aaacgggaga gcttgtgttt      900

ttgaagtgga aaaaaaccca agagtttgta cagacatcct gtcttcccag agaaggtgga      960

cactcttggg ctcattgtaa agtgcctgct gcatcaataa agctcttggc ttattagtct     1020

atacattgcg gtgtgtttcg tgtatgtaaa aaaaaatggt aatgaatggg atggtaatga     1080

atgagagttc agttgttgtt ccggaaaccc gatgtggaag gagtagacct gtgtccctgt     1140

tgagccaccc ctgggagcga gcatggcaat ccacaggccc tctgccacag gacgccagcc     1200

tcggcctcag agctgccggc tgctgcagag aggtgtttgc tgaataaact atttattgtt     1260

tcttattcct ttgatttgta tgtaattaat tttggagctt atttaattaa tttaataaag     1320

tgcca                                                                 1325


<210> 357
<211> 4576
<212> DNA
<213> Homo sapiens

<400> 357
gacagagcgc aatggcggca accgcgtctg caggggtgcc ggcgaccgtg tcagaaaagc       60

aagagtttta ccagcttctg aagaacctga tcaatccaag ctgtatggtg cggaggcaag      120

cagaggaaat ctatgaaaat atcccaggtc tgtgtaagac taccttcctc ttagatgccg      180

tcagaaatag aagagcaggt tatgaggtga gacaaatggc tgccgcactg ctacgacggc      240

ttttgtcctc tgggtttgag gaggtttatc caaatctgcc tgctgatgtt cagagagatg      300

tcaagattga actgattctg gctgttaagt tagaaacaca tgctagcatg aggaaaaaac      360

tttgtgatat ttttgcagtg ctggccagga atttgataga tgaggatggc actaaccact      420

ggccggaagg tctgaagttt cttattgatt caatctactc caaaaatgtg gttctatggg      480

aagttgcact tcacgttttc tggcactttc ctgggatttt tgggacccaa gagcggcatg      540

atttggatat catcaaacgg ttgttggacc agtgtattca agatcaagaa catccagcaa      600

tcaggacatt atccgctaga gctgcagctg catttgtact tgctaatgag aataatattg      660

ctcttttcaa agactttgca gacttgcttc ctggaatctt acaggctgtg aatgactcat      720

gctaccagga tgatgattca gtgctagaat cccttgttga gattgcagat accgtaccta      780

agtacttggg tccttattta gaagatactc tacagttgag tttgaagtta tgtggagact      840

ctaggcttag taatctgcag cgccagctgg ccctcgaagt tatagtgacc ttgtctgaaa      900

ctgccactcc gatgttgaaa aaacatacaa atattattgc acaggcagtt cctcatatat      960

tagcaatgat ggttgatcta caagatgatg aggactgggt aaatgctgat gaaatggaag     1020

aagatgattt tgacagcaat gcagttgctg cggagagtgc actagacaga ctggcttgtg     1080

ggcttggtgg aaaagttgtt ttaccaatga ccaaggagca tatcatgcag atgcttcaga     1140

gccctgactg gaagtatcga catgctggat taatggcctt atctgccatt ggagaaggat     1200

gccatcaaca aatggaatca attctagatg aaacagttaa ctccgttttg ctttttcttc     1260

aggatcctca tccaagggtg agggctgcag cctgtactac acttggacag atggctacag     1320

attttgcacc taatttccaa aagaaatttc atgaaacagt gattgcagct ctgttacgta     1380

ccatggaaaa tcaaggtaat cagcgtgtgc aatcacatgc agcttctgct cttattattt     1440

ttattgaaga ctgccctaaa tcattgctag ttctatatgt ggatagtatg gtgaaaaatc     1500

tacattccgt cttggtgatt aaacttcaag agttgattcg gaatggaact aagttggctt     1560

tggaacaact tgtgacaacc attgcatcag ttgcagatac aatagaagaa aaatttgtcc     1620

catattatga tatattcatg ccctcactaa agcacattgt tgagcttgct gttcagaagg     1680

aactcaagct tctgagagga aaaactatcg agtgcattag ccatattggt cttgctgttg     1740

ggaaggaaaa atttatgcaa gatgcatcaa atgtgatgca gctgttgttg aagacacaat     1800

cagacttaaa taatatggaa gatgatgacc ctcagacctc ttacatggtt tcagcatggg     1860

ctagaatgtg taaaattctt ggaaaagatt ttcaacagta ccttccactg gttatcgagc     1920

ctcttattaa gactgcttca gctaaacctg atgttgctct cttagacaca caggatgtgg     1980

aaaatatgag tgacgatgat ggctggcaat ttgtaaatct tggagaccag cagagttttg     2040

gaattaaaac ttcaggactt gaagcaaaag caactgcttg ccaaatgttg gtttactatg     2100

ctaaggagtt aagggaaggg tttgtggaat atacagaaca agttgtgaag ctgatggttc     2160

ctttactgaa attttatttc catgacaatg ttcgagtggc agcagcagag tccatgcctt     2220

ttctcctgga atgtgcaaga attcgtggcc cagagtatct tgcacagatg tggcaattca     2280

tatgtgaccc cttaatcaag gctattggta ctgaaccaga tacagatgtg ctctcagaaa     2340

taatgaattc ttttgcaaag tccattgaag ttatgggaga tggttgcctt aatgatgaac     2400

acttggaaga actgggagga atactgaaag caaaacttga agggcacttt aaaaaccaag     2460

aattgagaca ggtgaaaaga caggaagaaa actatgatca acaggttgag atgtctctgc     2520

aagatgagga tgaatgtgat gtttatattc tgaccaaagt atcagatatt ttgcactcat     2580

tatttagtac ttataaggaa aagattttac catggtttga acaactactt ccattaattg     2640

taaatctaat ttgttcaagt aggccatggc cagacagaca gtggggattg tgcatatttg     2700

atgacatcat agagcactgc agtccaactt catttaaata tgtagaatat tttcggtggc     2760

caatgctact aaatatgcga gataacaacc ctgaagtcag gcaagctgct gcttatggcc     2820

tgggtgtcat ggcacagttt ggtggagatg attatcgttc tttatgttca gaagctgttc     2880

cacttctggt aaaagttatt aagtgtgcaa attccaaaac caaaaaaaat gtcattgcta     2940

cagagaactg tatctcagca atagggaaga ttttgaagtt taagcctaac tgtgtaaatg     3000

tagatgaagt tcttccacac tggttatcat ggcttccact gcatgaagat aaagaggaag     3060

ctattcagac tttgagtttt ctctgtgacc taattgaaag taaccaccca gttgtaattg     3120

gtccaaataa ttccaatctt cccaaaataa tcagtataat tgcagaagga aaaattaatg     3180

agactattaa ctatgaggat ccttgtgcca aacgcctagc taatgtcgtg cgtcaggtac     3240

agacttctga agatttatgg ttggaatgtg tatcacaact tgatgatgaa cagcaggaag     3300

ccttacagga gttgctaaat tttgcttgaa gcactttaat ataacttgaa tattatctat     3360

tataaaagta actacaaata agtgttgtga atagatttta ttataaatca gagaactgtt     3420

ttctccctgc taagcagttt atagttcttc tccatgtttc tccagaatta atcagtgtta     3480

gtcctctgtt tatctcgcat gttttatctt ccaaacacag accttggtga taacctgtgc     3540

ttcaaactgt cttaaacaat gtttgtcacc tttcccctag ttgatgtaaa gtatataaat     3600

tgttgctatt tgtttgaact attattgatg ctagccaagc agtatacttg atgtgaagat     3660

gtcatgctat cacaatatgc taagagctca caaaaataag atagaatttc caggacaaac     3720

atctttggaa ttgtgagtga aggatatagt ggcaggcttg tccctcttta attaatactc     3780

ttggtatttg tggtgatggg aggatgctgt tactaggaga gttttgagat actgcagtgg     3840

atgtgggatg tatatgaact tcttcataat gtactcctgg gaactgggta ggacatatcc     3900

atattgtagt tcccaaggtg tctggttgag agttagagaa cttttaaatt tctttagcca     3960

gacaggtctc tattttttta agttatccag gactccaaga accatagtta ctgaaaaggg     4020

agtcctgata catctaatat tggtagcatg taacagtgtt tgacaaagag taagtaagca     4080

gtattcttgg gagtcagtgt tatgtgtttc agcagagtat tattttgtat atgtatgcca     4140

ttttctccct gcaaagcagc tcaacaagag aaaaagctct agttataggg cttaaattga     4200

tttctatttc aaataatttc ctaagagatt ctagagtaga actgaagagt attctattgg     4260

aaaagtgaaa ggaaagaaat gtaattttct ttgaacatga aaaagaaaac aactttgaga     4320

gtagtcattt agcagtagat gtgcattatt atgagaaaac agttctataa gtccagggtt     4380

aattatatta attggaatgt cagtctttaa tgtcgagctt attgtagggt agaaaagagc     4440

tttctactca gctaacgatt actcattgat ccaaaactta aatacatcta taatttcctg     4500

gggctattgt gagtactgtg tatgtattta gcaaatattt aagacctagt aagtgctcaa     4560

taaattgtag ctgtta                                                     4576


<210> 358
<211> 2688
<212> DNA
<213> Homo sapiens

<400> 358
agacgacctg ccccgccccc tgcgccaccg actgactcag tgacctcggg gtcgttaggc       60

ctccacgtcc tcgctggagc tgcggacctc agtcgtccat ccacacctcc cccctgccgc      120

ccccgcccat ctcactctcc caaccctggg caccagggca ggtcgacagc ccgaggcact      180

cctctactgc gtttccaggc ccaggagacc cactccagcg ccgcggttcc ttgcgacccg      240

gcagccgttc agcagacctc ccattctttc ctgcatcatc gggcattgtg gaggcaccct      300

acggtgattc ctctcagagc ctgtttgtag gtgaccgtga cagagacaaa accatggaag      360

tgactgggtt tggagtgacc agaccgggca aggtccccca ggccaggatg tcaggcctgg      420

tgttggggca gcgggatgag cctgcaggcc accggctcag ccaagaggag atcctgggga      480

gcacacggct ggtcagccaa gggctagagg ccctacgcag tgaacaccag gccgtgctgc      540

aaagcctgtc ccagaccatt gagtgtctgc agcagggagg ccatgaggaa gggctggtgc      600

atgagaaggc ccggcagctt cgccgttcta tggaaaacat tgagctcggg ctgagtgagg      660

cccaggtgat gctggctcta gccagccacc tgagcacagt ggagtcggag aaacagaagc      720

tgcgggctca ggtgcggcgg ctatgccagg agaaccagtg gctgcgggat gagctggctg      780

gcacccagca gcggctacag cgcagtgaac aggctgtggc tcagctggag gaggaaaaga      840

agcacctgga gttcctgggg cagctgcggc agtatgatga ggatggacat acctcggagg      900

agaaagaagg cgatgccacc aaggattccc tggatgacct ctttcctaat gaggaggaag      960

aggaccccag caatggcttg tcccgtggtc aaggtgctac agcagctcag cagggtggat     1020

atgagatccc agcaaggttg cggacgttgc acaacctggt gatccagtac gcagcccaag     1080

gtcgctatga ggtggccgtg ccactctgta agcaggcact agaggacctg gagcgcacat     1140

caggccgtgg ccaccctgat gtcgccacca tgctcaacat ccttgctttg gtgtatcgtg     1200

accagaataa gtataaggaa gctgcccacc tgctgaatga tgcccttagc atccgggaga     1260

gcaccttggg acctgaccat cctgctgtgg ctgccacact caacaatttg gctgtgctct     1320

atggcaaaag gggcaagtac aaggaggcag agcctctgtg ccagcgggca ctggagattc     1380

gagaaaaggt cctgggcacg aatcatccag atgtggcaaa acagctgaac aacctggccc     1440

tcttgtgcca aaaccagggc aagtatgagg ccgtggaacg ctactaccag cgagcactgg     1500

ccatctacga ggggcagctg gggccggaca accctaatgt agcccggacc aagaacaacc     1560

tggcttcctg ttacctgaaa cagggcaaat atgctgaggc tgagacacta tacaaagaga     1620

tcctgacccg tgcccatgta caggagtttg ggtctgtgga tgatgaccac aagcccatct     1680

ggatgcatgc agaggagcgg gaggaaatga gcaaaagccg gcaccatgag ggtgggacac     1740

cctatgctga gtatggaggc tggtacaagg cctgcaaagt gagcagcccc acagtgaaca     1800

ctactctgag aaacctggga gctctgtata ggcgccaggg aaagctggag gctgctgaga     1860

ccctggagga atgtgccctg cggtcccgga gacagggcac tgaccctatc agccagacga     1920

aggtggcaga gctgcttggg gagagtgatg gtagaaggac ctcccaggag ggccctggag     1980

acagtgtgaa attcgaggga ggtgaagatg cttctgtggc tgtggagtgg tccggggatg     2040

gcagtgggac cctgcagagg agtggctctc ttggcaagat ccgggatgtg ctccgcagaa     2100

gcagtgaact cttggtgagg aagctccagg ggactgagcc tcggccctcc agcagcaaca     2160

tgaagcgagc agcctccttg aactatctga accaacctag tgcagcaccc ctccaggtct     2220

cccggggcct cagtgccagc accatggacc tctcttcaag cagctgacat tcaacccggc     2280

ccccaggtct gctgggtccc cccaccccca cagccctcac agcattcccc attgctcctg     2340

gctcttcccc acccctaggt gggacagtga aggggagcag tttaaccaga agattgctgc     2400

tgcccttagg gtctcagctc cctcctcagg aatccctctt aggaaggacc ctcaggacac     2460

cctctctgca ccctgtggtc ctctagagta gctagctctg aggccccaag gtgggtacaa     2520

agcaggtatg gccctcagag atgcagcctg ctgctggctt ttcagtcaga gggttggggg     2580

ctggccagcc aagctgcctt gccctggccg ctcttactcc ctccctctgc tgtctcactt     2640

caggtccatg tatttcactt ttcttaaata aaagaatcag gtaacctt                  2688


<210> 359
<211> 6932
<212> DNA
<213> Homo sapiens

<400> 359
cagccgcagc cgcagcgggc acagagcagg tagatggccc cctcagggca ggcccggcgg       60

acacccctcc ctctggctgg cggatgcagt gcctagcggc cgcccttaag gacgaaacca      120

acatgagtgg gggaggggag caggccgaca tcctgccggc caactacgtg gtcaaggatc      180

gctggaaggt gctgaaaaag atcgggggcg ggggctttgg tgagatctac gaggccatgg      240

acctgctgac cagggagaat gtggccctca aggtggagtc agcccagcag cccaagcagg      300

tcctcaagat ggaggtggcc gtgctcaaga agttgcaagg gaaggaccat gtgtgcaggt      360

tcattggctg tggcaggaac gagaagttta actatgtagt gatgcagctc cagggccgga      420

acctggccga cctgcgccgt agccagccgc gaggcacctt cacgctgagc accacattgc      480

ggctgggcaa gcagatcttg gagtccatcg aggccatcca ctctgtgggc ttcctgcacc      540

gtgacatcaa gccttcaaac tttgccatgg gcaggctgcc ctccacctac aggaagtgct      600

atatgctgga cttcgggctg gcccggcagt acaccaacac cacgggggat gtgcggcccc      660

ctcggaatgt ggccgggttt cgaggaacgg ttcgctatgc ctcagtcaat gcccacaaga      720

accgggagat gggccgccac gacgacctgt ggtccctctt ctacatgctg gtggagtttg      780

cagtgggcca gctgccctgg aggaagatca aggacaagga acaggtaggg atgatcaagg      840

agaagtatga gcaccggatg ctgctgaagc acatgccgtc agagttccac ctcttcctgg      900

accacattgc cagcctcgac tacttcacca agcccgacta ccagttgatc atgtcagtgt      960

ttgagaacag catgaaggag aggggcattg ccgagaatga ggcctttgac tgggagaagg     1020

caggcaccga tgccctcctg tccacgagca cctctacccc gccccagcag aacacccggc     1080

agacggcagc catgtttggg gtggtcaatg tgacgccagt gcctggggac ctgctccggg     1140

agaacaccga ggatgtgcta cagggagagc acctgagtga ccaggagaat gcacccccaa     1200

ttctgcccgg gaggccctct gaggggctgg gccccagtcc ccaccttgtc ccccaccccg     1260

ggggtcctga ggctgaagtc tgggaggaga cagatgtcaa ccggaacaaa ctccggatca     1320

acatcggcaa aagcccctgt gtggaggagg aacagagccg aggcatgggg gtccccagct     1380

ccccagtgcg tgccccccca gactccccca caaccccagt ccgttctctg cgctaccgga     1440

gggtgaacag ccctgagtca gaaaggctgt ccacggcgga cgggcgagtg gagctacctg     1500

agaggaggtc acggatggat ctgcctggct cgccctcgcg ccaggcctgc tcctctcagc     1560

cagcccagat gctgtcagtg gacacaggcc acgctgaccg acaggccagt ggccgcatgg     1620

acgtgtcagc ctctgtggag caggaggccc tgagcaacgc cttccgctcg gtgccgctgg     1680

ctgaggagga ggatttcgac agcaaagagt gggtcatcat cgacaaggag acggagctca     1740

aggacttccc tccaggggct gagcccagca catcgggcac cacggatgag gagcccgagg     1800

agctgcggcc actgcccgag gagggcgaag agcggcggcg gctgggggca gagcccaccg     1860

tccggccccg gggacgcagc atgcaggcgc tggcggagga ggacctgcag catttgccgc     1920

cccagcccct gccaccccag ctgagccagg gcgatggccg ttccgagacg tcacagcccc     1980

ccacgcctgg cagcccttcc cactcacccc tgcactcggg accccgccct cgacggagag     2040

agtcggaccc cacaggccca cagagacagg tgttctccgt ggcgccccca tttgaggtga     2100

atggcctccc acgagctgtg cctctgagtc tgccctacca ggacttcaaa agagacctct     2160

ccgattaccg agaacgggcg cggttgctca acagggtccg gagggtgggc ttctcgcaca     2220

tgctgctcac caccccccag gtcccactgg ctcctgttca gcctcaggct aatgggaagg     2280

aggaagagga ggaggaggag gaagatgagg aagaggaaga agaggatgag gaagaagaag     2340

aggaggaaga ggaagaggag gaggaagaag aggaggagga ggaagaggag gaggaggctg     2400

cagcggcagt tgccttgggg gaggtgctgg ggcctcgtag tggctccagc agtgagggga     2460

gtgagaggag cactgaccgg agccaggagg gtgccccgtc cacgctgctg gcagacgatc     2520

agaaggagtc caggggccgg gcctccatgg ccgatgggga cctggagcct gaggagggct     2580

ccaaaacgct ggtgcttgtc tctcctggcg acatgaagaa gtcgcccgtc actgccgaac     2640

tggcccccga ccccgacctg ggcaccctgg ctgccctcac tcctcagcat gagcggcccc     2700

agcccacggg cagccagctg gacgtatctg agccaggcac cctgtcctct gtcctcaagt     2760

ctgagcccaa gcccccgggg cctggggcag ggctgggggc cgggacagtg accacagggg     2820

tcgggggcgt ggcagtcacc tcctcaccct tcaccaaagt tgagaggacc tttgtgcaca     2880

ttgcggagaa aacccacctc aacgtcatgt cttccggtgg acaagccttg cggtctgagg     2940

agttcagcgc tgggggcgag ctgggtctgg agctggcctc tgatgggggc gctgtggagg     3000

agggggcccg agcgcccctg gagaacggcc tcgccctgtc agggctgaat ggggctgaga     3060

tagagggctc tgccctgtct ggggcccccc gggaaacccc ctcagagatg gccacaaact     3120

cactgcccaa tggcccggcc cttgcagacg ggccagcccc ggtgtccccg ctggagccaa     3180

gccctgagaa agtggccacc atctccccca gacgccatgc tatgccaggc tctcgcccca     3240

ggagccgtat ccctgtcctg ctctctgagg aggacacggg ctcggagccc tcaggctcac     3300

tgtcggccaa agagcggtgg agcaagcggg ctcggccgca gcaggacctg gcgcggctgg     3360

tgatggagaa gaggcagggc cgcctgctgt tgcggctggc ctcaggggcc tcgtcctcct     3420

ccagtgagga gcagcgccgt gcctctgaga ccctctcagg cacgggctct gaggaggaca     3480

cgcccgcctc tgagccggca gcggccttgc ccaggaagag cgggagggca gccgccacca     3540

ggagccggat tccccgcccc attggcctcc gcatgcccat gcctgttgca gcccagcagc     3600

ccgccagcag atcccatggc gcggccccag cattggacac agccatcacc agcaggctcc     3660

agctgcagac gcccccaggg tcggccactg ctgctgacct ccgccccaaa caacctcctg     3720

gccgcggcct gggcccaggg cgagcccaag ccggagccag gcccccagcg ccgcgcagcc     3780

cgcgcctccc cgcgtccaca tccgccgcgc gcaatgccag cgcgtccccc cggagccagt     3840

ccctgtcccg cagagagagc ccctccccct cgcaccaggc ccggcccggg gtccccccgc     3900

cccggggcgt cccgccggcc cgggcccagc ctgatggcac cccctccccc gggggctcca     3960

agaaaggacc cagagggaaa ctccaggctc agcgcgcaac aaccaaaggc cgggcaggag     4020

gcgcggaggg ccgggctggg gccagataat gacgcccgct gctctccgcg gtcccccacc     4080

ctcaccccgg ccccccaccc gcagccggcc acactggagc agctcccagc acagccttac     4140

gcgcccgacg cgcgccaccc gcggccccag ctttccgcct gcacccgcga ggacgcgcgc     4200

gagcacacgc ggcgccccgc caggccttag ggcccgtggg ggacgcggcc ccgcgccgcg     4260

gggagggtct gcctcccctt cctcgccctg tgtcctctca tcctcccgcc gcccgtcagg     4320

ccggccagcc tcacatcagt ctctccgccc cggggaaggc tcagccactt ttcatcgagg     4380

actccacttc tggggacgcc tggttcgttc gcccaccagg cctaggctac gctccatgct     4440

cccccagcaa tctctgccta cacctcctgc ggcgccttgc cctcctccga cccctttcca     4500

gccaaagtcc ccccacccct tcagagaagc agcctcaaat tccagaagtg gaggctccag     4560

cctccccgcg agggtccagc cccacagtct tctgggagcc attgtggcca gggacggcct     4620

ctggactgcc aggctgggtt ggggacccag ggaacatcgg tctactcagg tgtgaggggg     4680

caggtctgac ctgccccaaa gttggctcca tcctggacaa ctcggtgaga ggcagtgggc     4740

aagtgatctt ggagatgggt gggcaggtga ttctgtgggc aggggatgtg ctcccctgca     4800

cctctggggt gcagaaacct cttgcctcca gatttgggtg gagcctctgt gggaaccata     4860

ggaagtgtgt gggctgcctt cctgggcaag tatttcccag tgggaagttg gagggggctt     4920

taacaaagtt ttactccctc ccctgttccc ctgatctagt gctcaggacc cttcaccatc     4980

aggaattcct tcctgtcatc taacctcagt cctgcctact gcagttccag ccaacctgct     5040

ctttcctgag ttcaaagcag gtggagactg gctggttacc atctttgcac tggcccttcg     5100

gagattcggg gactcagttc tggtggggtc accctccctg tcctcccgcc tgtgggaggg     5160

agggagggct ggctcaggca tcgtctcccg caatgggcag agagagcaga gacaggtgga     5220

ccaacagaca gctggcccct ggaggcagaa aggcccttct aacttccaga ttgtatgctt     5280

gagtgatggg tccccagccc aagcccactc ttccctcagc tcacccttca gcctgttcct     5340

tcttgccctg accccagccc gtgcagctgc tctactccag gaatggatgt ggggactctt     5400

cctgggttct ggctcctgca tagctcaccc cacctcatca tgagcctcaa ctgcctacat     5460

ctggggcaag cagcacaccg gctgcagatg ggacagccag ccctgcctat ctggacaggc     5520

ccctgcagcc tctgtcccct ggcctagcct ctctgtcctt ccctgagtca cagagagcaa     5580

gccaagacat ccagggaaag aggaagaaag gccttagtgt gccccagcag tctggctgcg     5640

tccagccacc atcacccgga aggatgccca caaggcagct gaccctgaaa gcagcctccc     5700

cctcatggag agtcagcagc ttgggcagcc acttccaggc cagggtggtg gcttctctgc     5760

agaccagctg aggggaggac tcctgggtgg acagcctttg acgtccaccc cacgctgatg     5820

cagaagctcc cagaacactc aggaaacttc tccggacaga gccctccttg tcaacttgag     5880

gccctcccaa ggccctctac tgccctctgg gtccagcaga gggagtggag gaagggccac     5940

tgcctcccac ctagagcttc tccgaatgac aatcagctcg tgccaggtgg ggaccaggat     6000

atgactcctg gtgcccaggc cctgggcctg ctccttgcca ccaaccgaac cgtgaatgta     6060

gggcccccag cctcacctct gccccaggac caacaacacc ctggtttgga gctgggagga     6120

agaagggggc ctgagagagc cccaggtcca ttctaccccc agcttcactc agcactggag     6180

ctggcagaga cgcaaaaccc agtctgccct tgggattcca aacctcccta gggctcccaa     6240

ctgacctcag gcctctgagt cactgaatgt caccaggaga ggtgggggag ggaaagtggg     6300

ccagtgggga gggggtcacc taggggactg cctctgtgcc tctccccagg aagcatccag     6360

ggcagaggaa gccacatctc ccggtgcccc caaccccagc tgcagcctcc tccccctgag     6420

cattcattct ctccaccagg cctccaggtc ctgagccctt cctctgtaaa agtgtcacac     6480

cacctccctc agcacttccc catcacaaca acctatgtca ctgactcaga tgcagggtct     6540

gctcacccca acacatgcct tccctcccca gccacaccgt gcacgaaggg ggcacaggag     6600

aggagagggg ctgtgcccca ggctccccat ttcccagctc ctcacagagg cctggtttgc     6660

tcagtcttct gaactccagg gaccagccct ggtgggcatg gggtggggag cagggagttg     6720

cccttcccct ccctcgggaa gccacctaag aatgtttaca tgccaaacag aatgtaacac     6780

ccctccccaa gcccttccca gtcactgcat ggcctctgcc catcctgcac ctgtccaccc     6840

caccccaaca ccctggaagc cactgtcaat gattagatcg ggtctcggaa gggaagtagc     6900

catcacacca ttaaaaagcc tgtggacctt tt                                   6932


<210> 360
<211> 3732
<212> DNA
<213> Homo sapiens

<400> 360
agtgacgcga gacgcggggt gtggctctgc cggcccaggc gcgatgaggc ggctgcccgc       60

tgggtggcgc cgatttcccg gggaggtccc ttctgggccc ccggcggagg tgggagagag      120

tcaggcagga gccgaggccg gggagccctc ttcgtcagct ggtgctcact gcgccgcgcc      180

agcgccagcc gggactcacc cgcagctcca tgcttgtgcc cggttcgact cgtccatact      240

ccaagaagag gcagcccatg aggctcccag tccccactga gtgccaccct gaaggatgtc      300

ccagctctcc tccaccctga agcgctacac agaatcggcc cgctacacag atgcccacta      360

tgccaagtcg ggctatggtg cctacacccc gtcctcctat ggggccaatc tggctgcctc      420

cttactggag aaggagaaac ttggtttcaa gccggtcccc accagcagct tcctcacccg      480

tccccgtacc tatggcccct cctccctcct ggactatgac cggggccgcc ccctgctgag      540

acccgacatc actgggggtg gtaagcgggc agagagccag acccggggta ctgagcggcc      600

tttaggcagt ggcctcagcg ggggcagcgg attcccttat ggagtgacca acaactgcct      660

cagctacctg cccatcaatg cctatgacca gggggtgacc ctaacccaga agctggacag      720

ccaatcagac ctggcccggg atttctccag cctccggacc tcagatagct accggataga      780

ccccaggaac ctgggccgca gccccatgct ggcccggacg cgcaaggagc tctgcaccct      840

gcaggggctc taccagacag ccagctgccc tgaatacctg gtcgactacc tggagaacta      900

tggtcgcaag ggcagtgcat ctcaggtgcc ctcccaggcc cctccctcac gagtccctga      960

aatcatcagc ccaacctacc gacccattgg ccgctacacg ctgtgggaga cgggaaaggg     1020

tcaggcccct gggcccagcc gctccagctc cccgggaaga gacggcatga attctaagag     1080

tgcccagggt ctggctggtc ttcgaaacct tgggaacacg tgcttcatga actcaattct     1140

gcagtgcctg agcaacactc gggagttgag agattactgc ctccagaggc tctacatgcg     1200

ggacctgcac cacggcagca atgcacacac agccctcgtg gaagagtttg caaaactaat     1260

tcagaccata tggacttcat cccccaatga tgtggtgagc ccatctgagt tcaagaccca     1320

gatccagaga tacgcaccgc gctttgttgg ctataatcag caggatgctc aggagttcct     1380

tcgctttctt ctggatgggc tccataacga ggtgaaccga gtgacactga gacctaagtc     1440

caaccctgag aacctcgatc atcttcctga tgacgagaaa ggccgacaga tgtggagaaa     1500

atatctagaa cgggaagaca gtaggatcgg ggatctcttt gttgggcagc taaagagctc     1560

gctgacgtgt acagattgtg gttactgttc tacggtcttc gaccccttct gggacctctc     1620

actgcccatt gctaagcgag gttatcctga ggtgacatta atggactgca tgaggctctt     1680

caccaaagag gatgtgcttg atggagatga aaagccaaca tgctgtcgct gccgaggcag     1740

aaaacggtgt ataaagaagt tctccatcca gaggttccca aagatcttgg tgctccatct     1800

gaagcggttc tcagaatcca ggatccgaac cagcaagctc acaacatttg tgaacttccc     1860

cctaagagac ctggacttaa gagaatttgc ctcagaaaac accaaccatg ctgtttacaa     1920

cctgtacgct gtgtccaatc actccggaac caccatgggt ggccactata cagcctactg     1980

tcgcagtcca gggacaggag aatggcacac tttcaacgac tccagcgtca ctcccatgtc     2040

ctccagccaa gtgcgcacca gcgacgccta cctgctcttc tacgaactgg ccagcccgcc     2100

ctcccgaatg tagcgccagg agccacgtcc cttctccctt ccccgtggtg gccccgctcc     2160

ctaaattttt taaaaagaca aaaacaaaac aacaacaaca acacacaaac ctgacaagag     2220

aaaaacaaac ctgaagctgc cgagcaggag tggatgcagc ctgatcaggg tctggagcaa     2280

ggagccgggc tttcctgagc tgtggcccgg cagggaagat cgcctggacg tggagccagc     2340

atcgccccgt gccctcggcg tttgcatttg taaacttgtg gtcttcctat gtgtcagaaa     2400

caactgtgtc ttggggggga agaccctcgc tgcgccgctt cccgccgcag cgcccgcgcc     2460

tccgagggga cagcgccctc tggagctcgc tgggagcatc accgcctgga cgcccgcgcc     2520

gcggaggagc cggcgcccat ctccacccgc acggctcgcc ggtccagagc catgagccaa     2580

gagccctctt cacgctgcta actccagggg acagacgaag ggacatcttt ggaaaacgct     2640

ggttttggtt tttaaaaagc ccaacttttt ttttttaatt tccataacta aagtgttcag     2700

actggagtgc tctccttcag gcctcttcat agctgggacg ttgcactggt ccttttattg     2760

cttttccaag tacaactttc taatgctagc cctccgtggt gctaggtggg cgttggccag     2820

gccccaagca cagccacagt agacctggga tctaaaacaa gtttctgttt tgggggtttg     2880

ggtttttttt tttttttttt aatgttttga atggaattta gttgcctcca agaattgtgc     2940

cttatagcat ttggggacca gggggtaact gcccctcctg aaatatccct cagcctcttc     3000

ccttttcccc agtgctctgt tcaaacccgc ctgggaaagg gatcctgccc ttagccctgg     3060

ctcgttgtgc attgcagtga ggcaaagaag aaagcaggta gattccttcc gacagggcat     3120

caagttcttc ccgcccacgt cctctagccc acccctggtc tgctccccag ctgtttgaag     3180

gatagcacaa gcccctcgtc cctagagctt ctctcccttt tatttattct cttaacatcc     3240

ctttccccct ggccttcctg cccccgcccc cttctcagag cctcctagac aataggccct     3300

ttggaccgag tttctcaggg atgcccaggc cacccctcag ctcttcttag cgctggtctc     3360

cagtcctgcc ctgggagctg gagcctgggt atttggggac atcttgcctc agttgtatgg     3420

ttctttcctg tgggctcaat tttgccctac atagttggat aaaactctgt gctgtcctgg     3480

agagtaaagc tgttcaccca cacagctggg cccggcttgt gccccgtgga gcctggcaca     3540

ttccaggctc ctaggaggag gcatcagaga aagacaccct gagttttact ggcctgacac     3600

ccttctccag agaagacctg tgaacctgag cccaagggca agtgtacact tgtttactgt     3660

gtaagcaaga gtagaagaat gtctaatgta cagtggaacc ttgtacagaa taaataatag     3720

ctttgagaaa tc                                                         3732


<210> 361
<211> 1940
<212> DNA
<213> Homo sapiens

<400> 361
cgcgcaaggg gcgagtctgt ccagccggca gcaccccagg ccggatggac gcttgttcct       60

ggttctgtgc cccgtgagcg ctcaacgccc tggtgtgttc actgaccatg gtgcctgggc      120

tgcggcgccg ggcggggcac ggcgggactt ttcgggacct ttcctggggg gagcctcgct      180

ttccccgcct ccagcctccg cccggatggc aggcgggcgg ggccccagtc caggccttga      240

gacccagaag ggagcgaagg tttttgctgc gccaacgcag tgaccgaagg ctccgctcac      300

gcccggcctg atcctgcctg aagatggtgc cactggtggc tgtggtatca gggccccgtg      360

cccagctctt tgcctgcctg ctcaggctgg gcactcagca ggtcggcccc cttcagctgc      420

acaccggggc cagccatgcg gccaggaacc attatgaggt gctggtgctg ggtgggggca      480

gtggcggaat caccatggct gcccgcatga agaggaaagt gggtgcagag aatgtggcca      540

ttgttgagcc cagtgagaga catttctacc agccaatctg gacactggtg ggtgctggtg      600

ccaaacaatt gtcctcatct ggtcgtccca cggcaagtgt gattccatct ggtgtagaat      660

ggatcaaagc tagagtgact gagttgaacc cagacaagaa ctgcattcac acagatgacg      720

acgagaagat ctcctaccga tatcttatta ttgctctcgg aatccagctg gactatgaga      780

agattaaagg cctacctgaa ggtttcgctc atcccaaaat agggtcgaat tattcagtta      840

agactgtaga gaagacatgg aaagctctgc aggacttcaa agagggcaat gccatcttca      900

ccttcccaaa tactccagtg aagtgtgctg gagcccctca gaagatcatg tacttatcag      960

aagcctactt caggaagaca gggaagcgat ccaaggccaa tatcattttc aacacttctc     1020

ttggagccat tttcggggtt aagaagtatg cagatgccct gcaggagatc atccaggagc     1080

ggaacctcac tgttaactac aagaaaaacc tcattgaagt ccgagccgat aaacaagagg     1140

ctgtatttga gaacctggac aaaccaggag agacccaagt gatttcatat gaaatgcttc     1200

atgtcacacc tccaatgagc ccaccagatg tcctcaagac cagtcctgtg gctgatgctg     1260

ctggttgggt ggatgtggat aaagaaactc tgcaacacag gaggtaccca aatgtgtttg     1320

ggattgggga ctgcaccaac cttcctacgt caaagaccgc tgctgcagta gctgcccagt     1380

caggaatact tgataggaca atttctgtaa ttatgaagaa tcaaacacca acaaagaagt     1440

atgatggcta cacatcatgt ccactggtga ccggctacaa ccgtgtgatt cttgctgagt     1500

ttgactacaa agcagagccg ctagaaacct tcccctttga tcaaagcaaa gagcgccttt     1560

ccatgtatct catgaaagct gacctgatgc ctttcctgta ttggaatatg atgctaaggg     1620

gttactgggg aggaccagcg tttctgcgca agttgtttca tctaggtatg agttaaggat     1680

ggctcagcac ttgctcatct tggatggctt ctgggccaaa actgcagtca ctgaatgacc     1740

aagagcagca cgaaggactt ggaacctatc cttgtaaaga gttccttgat gggtaatggt     1800

gaccaaatgc ctcccttttc agtacctttg aacagcaacc atgtgggcta ctcatgatgg     1860

gcttgattct ttgggaataa taaaatgaaa taatactttt attttctgaa taaaagtttg     1920

tcactgattg tgttctatga                                                 1940


<210> 362
<211> 5634
<212> DNA
<213> Homo sapiens

<400> 362
aagcaatcga aagaagatgg ccgctcccac gattgtgggg gaggtctcca ctggggaggg       60

gcagaggaaa ttcggtcgaa aaagagataa agctgaagga aataaaattg gcacggagtc      120

tgggaaagta gtttccctaa aggagtctta gaaatagggt tggtctggaa cctaaggggc      180

ggagccgacg cgtagagccg ctttgcgcgt gcgcatcacc taggcggtta gatttgaata      240

cttcactgag gcgagccggg cgttgtgagc ggactgctag aggcggctgt ctgtttccgc      300

tctaaggaaa ctcagagcgt gtggacccca aacaagtctg cgcaaaattt gtcgaggagg      360

tttgccgcgg cagaaaagtt ttcttcaaaa atggatgggg tgtcttcaga ggctaatgaa      420

gaaaatgaca atatagagag acctgttaga agacggcatt cttcaatatt gaaaccccca      480

aggagtcctc ttcaggacct cagaggtggg aatgaaagag ttcaggaatc caatgctttg      540

agaaataaga aaaactctcg tcgagtcagc tttgcagata ctataaaggt attccagacg      600

gagtctcata tgaaaatagt gagaaagtca gaaatggaag aaacagaaac aggagaaaat      660

cttcttttga tacagaataa gaaattagaa gataattact gtgaaattac tgggatgaac      720

acattgcttt ctgctcccat tcatacccag atgcaacaga aggagttttc aattatagaa      780

catacccgtg aaaggaaaca tgcaaatgac cagacagtca ttttttcaga tgaaaaccag      840

atggacctga catcaagtca cactgtaatg attaccaaag gccttttaga taatcccata      900

agtgaaaagt ccaccaagat agataccaca tcatttctag ctaatttaaa gcttcacacc      960

gaggactcaa gaatgaaaaa agaagtaaat ttttccgtgg atcaaaacac ttcttcagaa     1020

aataaaatag atttcaatga cttcataaaa agattgaaaa caggaaaatg tagtgctttt     1080

cctgatgtgc ctgataaaga aaattttgag atacctattt attccaagga accgaacagt     1140

gcctcttcta cacatcaaat gcatgtatct cttaaggaag atgaaaataa cagtaatatt     1200

actaggctct ttagagaaaa agatgatggg atgaatttca cccagtgtca tacagccaat     1260

attcagacat tgattcccac atccagtgag accaactcac gggaatctaa aggtaatgat     1320

attacaattt atggcaatga ctttatggac ttgacattta accacacttt gcagatctta     1380

cctgcaacag gtaatttttc tgaaatagaa aatcaaactc agaatgccat ggatgtaaca     1440

acaggttatg gaactaaagc ttcaggaaat aaaacagttt ttaagagtaa acaaaatact     1500

gcttttcaag acctttccat aaactctgca gacaaaatac atattaccag aagtcatatt     1560

atgggggcag aaactcacat agtctcacag acttgtaatc aggatgccag aatattagcc     1620

atgaccccag aatctatata ttctaatcca tctattcaag gttgtaagac tgttttctat     1680

tctagttgta atgatgccat ggaaatgacc aaatgtctct caaatatgag agaggagaaa     1740

aatttgctaa agcatgacag taattatgct aaaatgtatt gcaatccaga tgctatgtct     1800

tctctcacag agaaaactat ttattccgga gaggagaaca tggacattac caagagtcat     1860

acagttgcaa tagataatca aatttttaaa caagatcaat caaatgtgca aatagcagct     1920

gcaccaacac ccgaaaaaga aatgatgctc caaaatctta tgaccacatc agaagatggg     1980

aaaatgaatg taaattgtaa ctcagttcct catgtatcta aggaaagaat acagcagagc     2040

ctgtcaaatc ctttgtctat ttcattgact gatagaaaga ctgaactctt atcaggtgaa     2100

aatatggatt tgactgaaag tcacacaagt aacttaggaa gtcaggttcc tcttgcagct     2160

tataatctag caccggagag taccagtgaa tctcactctc agagcaaaag ctcttcagat     2220

gaatgtgaag aaattaccaa aagtcgtaat gaaccatttc agcgatcaga cataatagcc     2280

aaaaacagct taaccgacac ctggaacaaa gacaaagatt gggttttgaa gattttgccc     2340

taccttgata aagattctcc tcagtcagct gattgtaatc aggagatagc aacaagccat     2400

aatatagtct actgtggtgg agttcttgat aaacaaataa ctaatagaaa tacagtatca     2460

tgggaacaat ctttgttttc taccacaaag ccattatttt catcaggaca gttctctatg     2520

aaaaatcatg atactgctat aagtagtcat acagtgaaat ctgtactagg ccagaattct     2580

aaactggctg agccactgag gaaaagttta agcaatccca cacctgacta ttgccatgac     2640

aagatgatta tatgttcaga ggaagagcaa aatatggatc taacaaagag ccacactgtc     2700

gtcattggat ttggtccttc tgaactacaa gaacttggta aaactaattt agaacacact     2760

actggccagc taacaacaat gaacagacag atagctgtaa aagttgaaaa atgtggtaaa     2820

agtcccatag aaaaaagtgg agtgcttaaa tctaactgta ttatggatgt gttagaggac     2880

gaaagtgtac agaaacctaa atttccaaag gaaaagcaaa atgtcaaaat ttggggaagg     2940

aaaagtgttg gtggaccaaa aattgataag actattgtat tttcagaaga cgataagaat     3000

gatatggata tcactaagag ttatacaata gaaataaacc atagaccttt attagagaaa     3060

cgtgattgtc atttggtgcc attggcagga acttctgaaa ctattttata tacatgtagg     3120

caggatgaca tggagatcac tagaagtcac acaactgcct tagaatgtaa aactgtctca     3180

ccagatgaaa taactactag gcctatggac aaaactgtag tgtttgtaga taatcatgtt     3240

gaactagaaa tgacagagtc ccatactgtt ttcattgact accaagaaaa ggaaagaaca     3300

gacagaccta actttgaact atcccaaagg aaaagcctag gaacaccaac agtgatatgt     3360

actcctactg aggagagtgt tttctttcca ggaaatggtg aaagtgaccg tctagtagca     3420

aatgacagcc agctaacccc tctggaggaa tggtctaata ataggggccc tgtagaggta     3480

gctgataaca tggaattgtc taaatcagcc acttgcaaaa acatcaaaga tgtacaaagt     3540

cctggatttc tgaatgaacc tctatcaagc aaaagtcaga gaagaaaaag ccttaagcta     3600

aaaaatgaca agaccattgt attttcagag aatcataaaa atgatatgga tattacccag     3660

agttgtatgg tggaaataga taacgaaagt gccctggagg ataaagagga cttccatttg     3720

gcaggggctt ctaaaactat tttgtattca tgtgggcagg atgacatgga gatcactagg     3780

agtcacacaa ctgccttaga atgtaaaact ctcctgccaa atgaaatagc tattaggccc     3840

atggacaaaa ccgtattgtt cacagataat tacagtgatc tggaagtcac cgattcccat     3900

actgttttca ttgactgtca agccacagag aaaatacttg aagaaaaccc taaatttgga     3960

ataggaaaag gaaaaaactt gggtgtttcc tttcctaagg ataatagctg tgttcaagaa     4020

atcgctgaaa aacaagcact ggctgtagga aacaaaatag ttcttcacac cgagcaaaag     4080

caacaactct ttgctgctac taatagaact actaatgaaa tcatcaaatt tcatagtgct     4140

gctatggatg aaaaggtcat agggaaagtt gtagaccagg cctgtacatt ggaaaaagcg     4200

caagttgaaa gctgtcagtt aaataataga gatagaagaa atgtggactt tacaagtagt     4260

catgcaactg ctgtttgtgg atccagtgat aattattcct gtttaccaaa tgttatttcc     4320

tgtactgata atttggaggg tagtgccatg ctcttatgtg ataaagatga ggaaaaagcc     4380

aattattgcc cagtgcaaaa tgatcttgct tatgcaaatg attttgccag tgaatattac     4440

ttggaatctg agggacagcc tctctctgct ccttgtcctt tgttagagaa ggaagaagtt     4500

attcaaacca gtaccaaagg acagttagac tgtgttataa cactgcacaa agatcaagat     4560

ctgattaagg atccacgaaa tctattggct aatcaaactt tagtatatag tcaagatctg     4620

ggggagatga ctaaacttaa ttcaaagcga gtatctttta agcttccaaa ggatcaaatg     4680

aaagtctatg ttgatgacat ttatgttatt cctcagcctc atttctcaac cgaccaacct     4740

ccattaccta aaaaaggaca gagtagtatc aataaagaag aagtaatact gtctaaagct     4800

ggaaataaga gtttaaatat tatagaaaat tcctctgcac ccatatgtga aaacaagccc     4860

aaaatactca atagtgagga atggtttgct gcagcctgta aaaaagaact gaaggaaaat     4920

attcaaacaa ctaactataa tacagctcta gatttccaca gtaactcaga cgtaactaag     4980

caagtcattc aaactcatgt caatgctgga gaagcaccag atcctgtaat tacatctaat     5040

gttccatgtt ttcatagtat caaaccaaat ctgaataatt tgaatggaaa aactggagag     5100

tttttagcct ttcaaactgt tcatctacca ccccttccag agcaattact tgaattagga     5160

aataaggcac acaatgatat gcatatagtg caagctacag aaatacataa tattaacata     5220

atctccagca atgctaaaga tagtagagat gaggaaaata aaaagtctca taatggagct     5280

gaaaccacct ctctaccgcc aaagacagtt tttaaagata aagtaaggag atgttctttg     5340

ggaatctttt tgcctagatt gcccaacaag agaaattgta gtgtcactgg tattgatgac     5400

ctggaacaga ttccagcaga cacaactgat ataaatcact tagaaactca gccggtctct     5460

agcaaagatt caggcattgg atctgttgca ggtaaactga acctaagtcc ttctcaatat     5520

ataaatgagg aaaatcttcc tgtatatcct gatgagatca attcttcaga ctctattaac     5580

atagaaactg agccaaaaaa gaacgtgggt acaagaagaa gaagatattc ataa           5634


<210> 363
<211> 2788
<212> DNA
<213> Homo sapiens

<400> 363
aatactcccg ctctgttttt atgaggctgg gaaaatagaa cgaggaagtg gtgacgcact       60

gggctctcac gaatacaact agaagctgca acgactgtgt ggctctatcg attcgggaga      120

ggtccagacc ggaaatggtc gtttccatgg taaccctgag caggttgcct gggagatgac      180

ctctttcggg tctctttgaa tctccgctgt agcgtcacct ggaaggcaga tctaacagag      240

aacctggact gtctcctatc atgattcccg ggaaatatcg ctctgtttct ggccgggctg      300

cgaacaacgt gaactgcggg cttcatctgg ttattcaaac atcatcgctt cctgaaaaaa      360

acaaagttga attcaagcta aataaagaca catcgtcatt ccccggtaga cttttacaac      420

atgaccttga aagaaactac tcaagtaggc aaggtgatca tattaatttg gtgagctcat      480

cattgtcatc atttcctatt cttcaacgtt cttctgaaga gaaaattctt tactcagaca      540

ggttgagcct agaaagacaa aagctgaccg tatgtcctat catcaatggg gaagaccacc      600

ttcgtttgtt gaactttcaa cacaatttta taactcggat acaaaatatt tctaatctac      660

agaagttaat atcgttggat ttatatgata accagattga agaaattagt gggctttcga      720

ctctgagatg tcttcgtgtc cttctgttgg ggaaaaacag aatcaagaaa atctcaaatc      780

tggagaatct aaaaagctta gatgtcttgg atcttcatgg aaatcagatt accaaaattg      840

aaaatattaa tcatttgtgt gagttgagag ttttaaatct tgccaggaac tttttaagtc      900

atgttgataa tcttaatggg ctggattcac taactgaact taacttgcga cacaatcaaa      960

tcactttcgt gagagatgtg gataatttgc cctgcctcca acatctcttt ctcagcttta     1020

acaatatatc tagttttgac agtgtttcct gccttgctga ctcttcttcc ctctcggaca     1080

tcacctttga tggcaatccc atagctcaag agtcatggta caaacacact gtccttcaga     1140

atatgatgca gctgcgccag ctagatatga agagaatcac ggaagaagaa aggcgtatgg     1200

catctgtttt agccaaaaaa gaggaagaga agaagcggga aagtcataaa caatctttgc     1260

ttaaggagaa gaaaaggtta acaattaaca acgtagctcg acagtgggac ttgcaacaac     1320

aacgagtagc caatattgct acaaatgaag atagaaaaga ttctgactct cctcaggacc     1380

cctgtcagat tgatggaagc accctctctg cattcccaga ggaaacaggg cctctagact     1440

caggactcaa caatgcttta caaggtttat ctgtcataga cacatacctt gttgaagtgg     1500

acggggatac actttcccta tatggctcag gagcactgga atctctggat aggaattgga     1560

gtgttcaaac agcaggaatg atcacaacag tctccttcac tttcatagaa tttgatgaaa     1620

tcgtccaagt gcttcctaaa ctgaagatta agtttcctaa ttctctgcac cttaaattca     1680

aggaaacaaa tcttgtaatg ctgcagcaat ttaacgcact agcccaactc cgtcgtattg     1740

accagttgac aattgatcct caaggaaatc cagttgtcaa ttttacactc tggaaatact     1800

atgtactgtt taggctaagc catttcagta tgcagaaaat aaatggaaca gaggtgacac     1860

agaatgatat gataatggct gaaaggctct ttggaatcct agcacatgta gcatcttctg     1920

agttacccca gtatcgtctg atttccattc tgggtgatgc caggaaaaag caatttcggt     1980

atctactaga atccaaagga aaaaaacctg gtattatcaa cgaagaaaat aatgacagca     2040

aaagacttgt aggagaaaac acaaatcgtg ctacattaaa ttatactaca agagactttt     2100

ataatgaaaa gctagaggaa ataaaggaaa agaagaaatt ctgtaaaaca tatatagaag     2160

accttgtgaa ggaagccaca gaaatcaaca tgaaaaatga ggctttgcag aagctttggc     2220

cacagatgtt cattgagctt gttagggatg cagtcataga aattcgcaat aaaaattcct     2280

atatgaagct ctgcctacag cagataacag accaaaaata aaaatggcct ttagttacag     2340

ttgattttgg cagttttatt ttttgaaggt tgaaaatatg caggttatac atgttaaaac     2400

aacaacaaca ctatcctata aactagaaag actagtataa aagcattatt gcccactgtt     2460

ctcatagcta aaagttaaga aggaaggaag gaaagcagga gaaaggaagg attaattgcc     2520

tgtatgtgag gaccaaacaa cctttgggaa ctaaacagtt ttcagagatg gcgtggcact     2580

gcatccttgg ttcttgcttt gattggtgcc ctgctatagc ccaaagcacg tagtatttgc     2640

tgatgattca gcatgagctg catctaccta cttttagctg ataattttca gttatttccc     2700

tttttatttt atgtcatgat ttcaaagcca aaaatatgtt ctttttatga gtgaagaata     2760

aacttactaa caaattagtc aaaataaa                                        2788


<210> 364
<211> 775
<212> DNA
<213> Homo sapiens

<400> 364
cacggcggtc acgggcaagg tgccccggga ttgacgccgc ctgtggccag agccggagta       60

acgggactcc cagctgcgcg tcgcagtccc gacgcgagaa gggctggagt cggcgtccag      120

cctagagccc ccggtgggag ccaggccggg acgcgtgcac catgccctac ctgctcatca      180

gcacccagat ccgcatggag gtgggcccca ctatggtggg cgatgaacag tcggatccag      240

agctgatgca gcatctgggg gcttcaaaga gaagagcctt gggaaacaac ttttatgaat      300

actacgtcga tgaccctccc cgcatagtcc tggacaagct ggaacgcagg ggcttccgtg      360

tgctgagcat gacgggggtg ggccagacgc tggtgtggtg tctgcacaag gagtgacctt      420

ctcatgctga tttgcagacg gggcacccct gtggaggggc tgctgtgggc cctgacctcc      480

aagctcctgc ctcaccgtct gccttgctcc tctcttccca aatcatcacc gccatgggcc      540

cagccccaaa gggcagtgaa tggccttctc tgaaaccctg cgtcaagcag tgggagaggg      600

cagtgcccgg tgccctggtg ctcccagctg ccctcctgct tcgggcctgg gccgagggcc      660

ttgtgtaggc catgttcctc gggcagctgc cccgggccgg agctgggcac tccagcggcc      720

ctggcgcgtg gctcctgcat agctagccca agccaataaa gggctgtgat gagtg           775


<210> 365
<211> 7976
<212> DNA
<213> Homo sapiens

<400> 365
gttccaggca ctccgcgtcg agcaccggag tcccgagccg tggctgccac gggcggtggg       60

cgggcggagg agagcaccgg accaccagtg caggctgccg agtcggggcg gccgcccacg      120

gggaagctgc gaggcgcggg agcacctggg ggaccgcttg cagcggggac gcgaggaccc      180

gggctgggct ttcctcaccc gggtaccttg ttatcccata actttggtat cctgaaatct      240

gaggattcca ccaagataat atgataagaa ctttcagtga tttggggcca tatcctactt      300

agactaatgt ggaatttcca gatttcctga gagcttggta cagcagcaca cactgcttgc      360

taatcagcac aggcaataat gccatctctg cctcaagaag gagttattca gggaccctct      420

cccctggatt tgaatacaga attaccttat caaagcacaa tgaaaaggaa agtcagaaag      480

aagaaaaaga agggaaccat tacagcaaat gttgccggga caaagtttga aattgttcgt      540

ttagtaatag atgaaatggg atttatgaaa actccagatg aggatgaaac aagtaatctt      600

atatggtgtg attctgctgt tcagcaggag aaaatttcag agctgcaaaa ttatcagagg      660

atcaaccatt ttccaggaat gggggagatc tgtaggaagg atttcttagc aagaaatatg      720

accaaaatga tcaagtctcg gcctctggat tatacctttg ttcctcgaac ttggatcttt      780

cctgctgaat atactcaatt ccaaaattat gtgaaagaat tgaagaaaaa acggaagcag      840

aaaactttta tagtgaaacc agctaatggt gcaatgggtc atgggatttc tttgataaga      900

aatggtgaca aacttccatc tcaggatcat ttgattgttc aagaatacat tgaaaagcct      960

ttcctaatgg aaggttacaa gtttgactta cgaatttata ttctggttac atcgtgtgat     1020

ccactaaaaa tatttctcta ccatgatggg cttgtgcgaa tgggtacaga gaagtacatt     1080

ccacctaatg agtccaattt gacccagtta tacatgcatc tgacaaacta ctccgtgaac     1140

aagcataatg agcattttga acgggatgaa actgagaaca aaggcagcaa acgttccatc     1200

aaatggttta cagaattcct tcaagcaaat caacatgatg ttgctaagtt ttggagtgat     1260

atttcagaat tggtggtaaa gaccctgatt gtagcagaac ctcatgtcct gcatgcctat     1320

cgaatgtgta gacctggtca acctccagga agcgaaagtg tctgctttga agtcctggga     1380

tttgatattt tgttggatag aaaactaaag ccatggcttc tggagattaa ccgagcccca     1440

agctttggaa ctgatcagaa aatagactat gatgtaaaaa ggggagtgct gctaaatgcg     1500

ttgaagctac taaacataag gaccagtgac aaaagaagaa acttggccaa acaaaaagct     1560

gaggctcaaa ggaggctcta tggtcaaaat tcaattaaaa ggctcttacc aggctcctca     1620

gactgggaac agcagagaca ccagttggag aggcggaaag aagagttgaa agagagactc     1680

gctcaagtac gaaagcagat ctcacgagaa gaacatgaaa atcgacatat ggggaattat     1740

agacgaattt atcctcctga agataaagca ttacttgaaa agtatgaaaa tttgttagct     1800

gttgcctttc agaccttcct ttcaggaaga gcagcttcat tccagcgaga gttgaataat     1860

cctttgaaaa ggatgaagga agaagatatt ttggatcttc tggagcaatg tgaaattgat     1920

gatgaaaagt tgatgggaaa aactaccaag actcgaggac caaagcctct gtgttctatg     1980

cctgagagta ctgagataat gaaaagacca aagtactgca gcagtgacag cagttatgat     2040

agtagcagca gctcttcaga atctgacgaa aatgaaaaag aagagtacca aaataagaaa     2100

agagaaaagc aagttacata taatcttaaa ccctccaacc actacaaatt aattcaacaa     2160

cccagctcca taagacgttc agtcagctgc cctcggtcca tctctgctca atcaccttcc     2220

agtggggaca cccgcccatt ttctgctcaa caaatgatat ctgtgtcacg gccaacttct     2280

gcatctcggt cacattcctt aaaccgtgct tcctcctaca tgaggcatct gcctcacagt     2340

aatgatgcct gctctaccaa ctctcaagtg agtgagtctt tgcggcaact gaaaacaaaa     2400

gaacaagaag atgatctaac aagtcagacc ttatttgttc tcaaagacat gaagatccgg     2460

tttccaggaa agtcagatgc agaatcagaa cttctgatag aagatatcat tgataactgg     2520

aagtatcata aaaccaaagt ggcttcatat tggctcataa aattggactc tgtaaaacaa     2580

cgaaaagttt tggacatagt gaaaacaagt attcgtacag ttcttccacg catctggaag     2640

gtgcctgatg ttgaagaagt aaatttatat cggattttca accgggtttt taatcgctta     2700

ctctggagtc gtggccaagg gctgtggaac tgtttctgtg attcaggatc ctcttgggag     2760

agtatattca ataaaagccc ggaggtggtg actcctttgc agctccagtg ttgccagcgc     2820

ctagtggagc tttgtaaaca gtgcctgcta gtggtttaca aatatgcaac tgacaaaaga     2880

ggatcacttt caggcattgg tcctgactgg ggtaattcca ggtatttact accagggagc     2940

acccaattct tcttgagaac accaacctac aacttgaagt acaattcacc tggaatgact     3000

cgctccaatg ttttgtttac atccagatat ggccatctgt gaaacagaag ggaagatcgc     3060

cattggttat acataacagc aattcatttt tttcctctga agttgaacat gcaaagaaca     3120

tgaccattaa gtgctgtttt atgtatataa gacatatata tgtgtgaaaa tatatgcaca     3180

tatgcaccct aataacatat atttattata ttaaatgata tatgaaagaa gaattagcag     3240

aaaatggaat ataagactta acctttctgg aaacgtaata aaccatgtta aaattgttta     3300

cacaaatatg tgaatgtcta gaatctgcta ggtttataat taattccttc ctactagaaa     3360

tgttattttt gctgcagagt atataaaaca aattgatctt gaagatccaa ttacagtgtt     3420

aaattatttt ctagataaca tgccttttga cctgaaaaag ggtttagtat aataccttaa     3480

aaattctcat atatagtagc cattttaaat gaaacaaaaa gatttagaag cctggtgttg     3540

cttgatgata agattaagaa gtttaaaacg ggtttatcat tactatagca cactgtaaag     3600

tgctagaaaa gtcataacct gattctccaa tctttttatt cctctatgtg gaaatttagc     3660

tacttgtaat aaggtacatt ttcagtaagg atctggtgag atcatattat gatctaacat     3720

gaaagacagg ctgggcgcgg tggctcacgc ctgtaattcc agcactttgg gaggccgagg     3780

tgagtggatc accgctggtc aggagtttga gactagcctg gccaacatgg tgaaacccca     3840

tctctactaa aaatacaaaa attagctggg cgtgatggta agtgcttgta atcccagcta     3900

cttgggcggc tgagacagga gaatcacttg aacctgggag gcggaggttg cagtgagccg     3960

agattgtgcc attgcattct agcctgggtg acaagagtga aactctgtct caaaaaaaaa     4020

aaataataat aaaataaaat aaataaataa ataaaaagaa gataaaaata aataaataaa     4080

atggaagaca atccaatggg ttaaaaataa aatgtaaact agctttcatt tttacttttc     4140

ataatcacat aaaggaacag aaaatgatgg taacaaaatc tttctatatg gcttttatgt     4200

cttataccac tcatttttat ttggaaagta tatctttgat gggtttaaca tgtggttaaa     4260

tacaatttct cctgtttcgc agaagtagaa gagttgacac atttcactca ttttagtgtt     4320

acaggataat gagacaaact tatttttata aatctctcaa ggttgaaatc aacttatatt     4380

gcaaattcta atacagtagt ttctcattgc accacagaaa cagttaaagg attgtgaata     4440

gaagatttca attatcacat attacaagtc atcagtgtac ccttgagggt ttttaaaaaa     4500

tcaaaacaga gaacgaagtg ttcttgtcca aagttgttat gcataagttt catagcagtt     4560

tacttccttt tcttgaatac agtttttaaa accaagagtg agctttcagt tttccataaa     4620

aatataagcc gtactacttt gacattgaaa tcatcagtgc agccatcact tcttagaatt     4680

tatttaaact tcttctccca acagttttat tttcttttag ctgctaatta ttttcgaaat     4740

tcatgaatgt tttacctcct tttactattc tgaaagttat ttcaagaagt ggccccaaag     4800

caggagaact gagaggggca aattggcctg gtttaattca cagcctgaag aattggcaac     4860

ctaaagttat aagttagatg tattttgctt ttcaagccat cttctgagcc ttttttaggc     4920

tgaaatgatt tgtttatttc ccaaattatt gctagctact tgatttttta tggctaccta     4980

acatccacat ttggtagata cttttcctct ctgcatgcat cccaaagaag aatttgctat     5040

ttgtggaaga agagaataag ggtatcagaa tgaaggaaat tacagtgact acactgttta     5100

tgactccatt ttgtgaattc ttaaatatgc tatggatttt tttttagaaa aaataatgca     5160

aaaattggga tattacagaa tcaccataaa gatgatcaac aagtaataag tcttttcatg     5220

gagttcattt ttcttttaaa ttcatgattt ggccacaaaa atatatatat aagtgtctga     5280

tatatgataa cagcccagtt tctcggccac tcatttgcat tatcttaaat cacaaataat     5340

tacttaattt gctggagtgt gtgctttgca acttttgtac cagagcaaaa tttgtattta     5400

aaacaaaaaa taagaatgcc catcactagg agaaacactc ctcacagaaa acacacacac     5460

acacacacac acaatttaaa aactgagtaa atttaaatgt atgaaagtac cccacaaatt     5520

gatttcaaca aataaatttc atttctctag ctacttatgt ctggccttat tttgagcgtt     5580

acaattttat tgccttcatt tgcctattta gactgatgta gtttgatatg atgaagttgt     5640

gaataaaagc cttgtgttca ttatttatat atactacctg gtatgctatg gactgtgtct     5700

gctgtagtgc tattccctaa tgagcaacta agagaagaca caacaataaa ccatggaagt     5760

gttgggaggc catggaaatg atttagaggt ataaaatatt cccaagtttt tattataaat     5820

ttttattcat aggttaaaac atataagcat aagtgattgt acaggtgtga ctcccttttc     5880

taggagagaa aatagcttta tttgaaaact ccaaaagcta cttaatctta ccagaggttt     5940

ttaatagggg aactgggttt acttacaatg aaagcatatt ttcattctgc tatagaaaaa     6000

catatccctg ctcattcagt aaatctaaga ttggaatgct ttctagaact atgcaatatt     6060

tgaataattt ctagaaatgt ctaagaaaca acctttttta ttttaaatca tcacttacaa     6120

acgtagtctg agactgcaaa ctagttttca cttgactaat ccatcattat agattagtta     6180

ccatttgctc tatataatct attgaagaaa ctattgttat tcatattttg attaatttta     6240

ctagcaacaa atttttattt tagtagcatt gcatttacct taaatatgta aaaatgaagt     6300

tgtaacagga tcaaatatgg aaatggcaat ggtaactctg cctagaacat agttgaatgt     6360

ccttggttgt cggtaagatg caaagatcta tacaaatttt atcataggtc aaaattattt     6420

ctaaatatac aaacagtttc aactatttct ttctccctaa aactaaaacc aaaccaaacc     6480

caaatgaaga aacctaaact tcttttcatc taatagttat acccaactag ataatagtag     6540

cttctagaca tcaataaaaa gatttcattt taactgtctt tttaatttgt aaaatatatg     6600

agtatggaat tttgtatcta acttgaaatt tcagatgttt taataatcca aatacgttct     6660

tctttagcat gtcaaagtac taatagttaa aaaatttctt tagatttaag catatacatt     6720

acttgacttt ttcaaaagta tcaaaaaatt gatagctgca gaaatgccat tatttgattt     6780

tctaaaaaac attgattcat tcttaaatgt gtattcttta aaaaatagta aatacctcaa     6840

gagtgacaga aaactttcct tttctgttct gtaatgctaa tttaaacttt gagtcttagt     6900

ttacatggtc ataggggtta aataaaatgt ataactgtac aattaattgt gttcttgtga     6960

cctgatgatt ttttgaaaat ttgcttttct ctttaagaaa tttaagtttt caagggccgt     7020

attagttatc taaatatttt gggctaatgt tgacttataa ataaataaaa atttagaaat     7080

atattcatga tgacaatttt gttacttaca ctgcctattc tttatttctt ttttagttca     7140

aaggtgaaat tttgaccttt gtattaacaa agcctcaaga aaagagaaat tctgcctttt     7200

aaacattggt tttccttgca ttttatggtg gtgtgatttt gcctcagcaa taataaaaca     7260

taaaatatgt tgttgcatca agttcagttt gtctgctgag attattttta agaaccaggt     7320

tgaagcctct atgcctaaaa aagcgtttat tgtctggata catataaagc aagatatatg     7380

gctacaaata agtcttgcaa ccaaaattgg tatattaaaa tttactgcac actttgagat     7440

tgctgccatt ttttggtgct ttttggacct cgtcataaag ggatgtatcg tatattaggg     7500

aaaattactc aagttacaca ttctacatta actgcgctgt attatctaca ggtacaatca     7560

atggaccaat agttcctaaa ttagtaataa ggcttacctt acaaaagtaa tgaaataaca     7620

ctgatatttc tctttcaaag gctaacagca attcttggtc ctgagctatt cagttcatac     7680

aataactact gtacatgcta caacatctga atattaatgg ttttgctgca gattctgggt     7740

atgaggatta gcttgaaagc aatacatttg ctaacatgaa tcatgactca cattatcccc     7800

gtgtgcttta ctacctgtat atgaatgcaa atgttgttac agaaaatatg cttgaaatgt     7860

caatacagtg tgcaattagc gttgcattgt catgctccag catgtgatat ctgtatggtg     7920

aagttatttc aattactctg atacattact ataataaaaa agtttaacct aagaaa         7976


<210> 366
<211> 1534
<212> DNA
<213> Homo sapiens

<400> 366
tcgtcaggct cctgcgcccc aggcatgaac caaggtttct gaactactgg gcgggagcca       60

acgtctcttc tttctcccgc tctggcggag gctttgtcgc tgcgggctgg gccccagggt      120

gtcccccatg gcggggccgc gggtggaggt cgatggcagc atcatggaag ggggcggcca      180

gatcctgaga gtctctacgg ccttgagctg tctcctaggc ctccccttgc gggtgcagaa      240

gatccgagcc ggccggagca cgccaggcct gagttctgga ggctggaagt ccaagatcaa      300

ggtcctgaca aggcctcaac atttatctgg actggaaatg attcgagatt tgtgtgatgg      360

gcaactggag ggggcagaaa ttggctcaac agaaataacc tttacaccag agaagatcaa      420

aggtggaatc cacacagcag ataccaagac agcagggagt gtgtgcctct tgatgcaggt      480

ctcaatgccg tgtgttctct ttgctgcttc tccatcagaa cttcatttga aaggtggaac      540

taatgctgaa atggcaccac agatcgatta tacagtgatg gtcttcaagc caattgttga      600

aaaatttggt ttcatattta attgtgacat taaaacaagg ggatattacc caaaaggggg      660

tggtgaagtg attgttcgaa tgtcaccagt taaacaattg aaccctataa atttaactga      720

gcgtggctgt gtgactaaga tatatggaag agctttcgtt gctggtgttt tgccatttaa      780

agtagcaaaa gatatggcag cggcagcagt tagatgcatc agaaaggaga tccgggattt      840

gtatgttaac atccagcctg ttcaagaacc taaagaccaa gcatttggca atggaaatgg      900

aataataatt attgctgaga cctccactgg ctgtttgttt gctggatcat cgcttggtaa      960

acgaggtgta aatgcagaca aagttggaat tgaagctgcc gaaatgctat tagcaaatct     1020

tagacatggt ggtactgtgg atgagtatct gcaagaccag ctgattgttt tcatggcatt     1080

agccaatgga gtttccagaa taaaaacagg accagttaca ctccatacgc aaaccgcgat     1140

acattttgct gaacaaatag caaaggctaa atttattgtg aagaaatcag aagatgaaga     1200

agacgccgct aaagatactt atattattga atgccaagga attgggatga caaatccaaa     1260

tctatagagt atttgcctct taaatgatac ctcattgata tattgcacta tttcataaat     1320

actataaaat aatgactagg aagtaactta ttaaaggcta tgacttaaat ttgaagatga     1380

agtacagtgt tctaggtttg ctgagaaggc ttcattaaat taatctcact ttgaatatct     1440

cctgagagat ggacaatgaa atatcagttg gtggatatgt gtgatagctg atttcaatat     1500

tgaagtattg aaataaaata ttctttacac ctga                                 1534


<210> 367
<211> 1399
<212> DNA
<213> Homo sapiens

<400> 367
agaaggcctc actcccagac tccttgcgga gctcgccgcc tgattctagg ctggtcacta       60

ctccgagcct gtgacgtttg cggcagccag gccgtcgacg atgcccagtg aaactctctg      120

ggaaattgca aaagctgaag tggaaaaaag gggaattaat ggaagtgaag gtgatggagc      180

tgaaattgca gaaaaatttg ttttcttcat tggcagtaaa aatgggggaa agactactat      240

tattctaagg tgtcttgaca gagatgaacc accaaaacca accttagctt tggaatatac      300

atatggaaga agagcaaaag ggcacaacac accaaaagat atcgctcact tttgggaact      360

cggtggagga acctctttat tggacttaat cagcataccc atcacaggtg acaccttacg      420

gacgttttct cttgttctcg ttctggatct ttcaaaacct aatgatctct ggcccaccat      480

ggaaaatctc ttgcaagcca caaaaagcca tgtagacaaa gtgataatga aactgggaaa      540

gacaaatgct aaagcagttt ctgaaatgag acagaagatc tggaataata tgccgaagga      600

tcatcctgat catgaattaa ttgacccatt tccggtacct ctggtcataa ttggaagtaa      660

atatgatgtt tttcaggatt ttgagtctga gaagagaaag gtaatatgca agacacttcg      720

atttgttgca cattattatg gagcatcatt aatgtttacc agtaaatcag aagctctatt      780

actaaaaata cgtggagtta tcaaccagtt ggcatttggc attgacaaaa gcaaatcaat      840

atgtgtggat cagaataaac cgctgtttat cacagcagga ttggattctt tcggtcaaat      900

aggatctcct cctgttcctg aaaatgacat tggaaagctt catgcccact cacctatgga      960

gttgtggaaa aaagtgtatg aaaagctctt tccaccaaag agtattaaca cgctgaaaga     1020

tatcaaggac cctgcgagag atcctcagta tgctgaaaat gaagtcgatg agatgagaat     1080

tcagaaggat ctggaactgg aacagtacaa aagaagttct tccaagtctt ggaaacaaat     1140

cgagcttgat tcttgaacct atttcaatta ttgtatattt atttcttctt ttccaaatac     1200

aaataagatt atactgtgaa ttaactattg tggcaatatg tgaagaaagt taaactgtat     1260

aatttgttaa aggacaagct ggatttcttg gactagtgca tctccctgta tatcttgaag     1320

ctttttaaaa ggaaaaatta ttgtagaacc acgtgtaatt ttttttaaaa taaaagaatc     1380

ttctactacc tacctctaa                                                  1399


<210> 368
<211> 934
<212> DNA
<213> Homo sapiens

<400> 368
gggattcctt accccatcac catgtgcacc tcagaaactt tccaagcgct ggacaccttc       60

gaagccagac atgatgacat cgtgctagca tcttatccaa agtgcggttc aaactggatt      120

ctccacattg tcagtgaatt aatatatgct gtttctaaaa aaaagtataa atatccagaa      180

ttcccagttc ttgaatgtgg ggattcagaa aaatatcaga gaatgaaagg ctttccatca      240

ccaaggattt tggcaactca cctccactat gacaaattac ctgggtctat cttcgagaat      300

aaagccaaga tattggtgat atttcgaaac cctaaagata cagcagtatc ttttttgcat      360

ttccacaacg atgtccccga tattccaagc tatggctctt gggatgaatt cttcagacag      420

ttcatgaaag gacaagtttc ttggggaagg tattttgatt ttgcaatcaa ttggaacaaa      480

catcttgatg gcgacaatgt taagttcata ttatatgaag acctgaaaga gaatctggct      540

gctggaataa aacagattgc tgagttcttg ggattctttc taactgggga gcaaattcaa      600

actatctcag tccagagcac cttccaagcc atgcgtgcga agtctcagga cacacacggt      660

gctgtcggcc cattcctttt ccgcaaaggt gaagttggtg attggaaaaa tttgttcagt      720

gaaattcaga accaggaaat ggatgaaaaa ttcaaagagt gcttagcagg cacctccctc      780

ggagcaaagt tgaagtatga atcatattgc cagggttgat tccagtcaat tcagcaggcc      840

tagatttatt ttccttaata ataattaagt gtaaataatt aaatgataat tcaatcaaat      900

aatcaaataa taattaaaca atattgaaat ctaa                                  934


<210> 369
<211> 6306
<212> DNA
<213> Homo sapiens

<400> 369
attgtttgaa tttgaaaacg gtaacatcgc agtgctgctc gcgggtctgg ctagtcaggc       60

gaagtttgca gaatggaatc taattttaat caagagggag tacctcgacc atcttatgtt      120

tttagtgctg acccaattgc aaggccttca gaaataaatt tcgatggcat taagcttgat      180

ctgtctcatg aattttcctt agttgctcca aatactgagg caaacagttt cgaatctaaa      240

gattatctcc aggtttgtct tcgaataaga ccatttacac agtcagaaaa agaacttgag      300

tctgagggct gtgtgcatat tctggattca cagactgttg tgctgaaaga gcctcaatgc      360

atccttggtc ggttaagtga aaaaagctca gggcagatgg cacagaaatt cagtttttcc      420

aaggtttttg gcccagcaac tacacagaag gaattctttc agggttgcat tatgcaacca      480

gtaaaagacc tcttgaaagg acagagtcgt ctgattttta cttacgggct aaccaattca      540

ggaaaaacat atacatttca agggacagaa gaaaatattg gcattctgcc tcgaactttg      600

aatgtattat ttgatagtct tcaagaaaga ctgtatacaa agatgaacct taaaccacat      660

agatccagag aatacttaag gttatcatca gaacaagaga aagaagaaat tgctagcaaa      720

agtgcattgc ttcggcaaat taaagaggtt actgtgcata atgatagtga tgatactctt      780

tatggaagtt taactaactc tttgaatatc tcagagtttg aagaatccat aaaagattat      840

gaacaagcca acttgaatat ggctaatagt ataaaatttt ctgtgtgggt ttctttcttt      900

gaaatttaca atgaatatat ttatgactta tttgttcctg tatcatctaa attccaaaag      960

agaaagatgc tgcgcctttc ccaagacgta aagggctatt cttttataaa agatctacaa     1020

tggattcaag tatctgattc caaagaagcc tatagacttt taaaactagg aataaagcac     1080

cagagtgttg ccttcacaaa attgaataat gcttccagta gaagtcacag catattcact     1140

gttaaaatat tacagattga agattctgaa atgtctcgtg taattcgagt cagtgaatta     1200

tctttatgtg atcttgctgg ttcagaacga actatgaaga cacagaatga aggtgaaagg     1260

ttaagagaga ctgggaatat caacacttct ttattgactc tgggaaagtg tattaacgtc     1320

ttgaagaata gtgaaaagtc aaagtttcaa cagcatgtgc ctttccggga aagtaaactg     1380

actcactatt ttcaaagttt ttttaatggt aaagggaaaa tttgtatgat tgtcaatatc     1440

agccaatgtt atttagccta tgatgaaaca ctcaatgtat tgaagttctc cgccattgca     1500

caaaaagttt gtgtcccaga cactttaaat tcctctcaag agaaattatt tggacctgtc     1560

aaatcttctc aagatgtatc actagacagt aattcaaaca gtaaaatatt aaatgtaaaa     1620

agagccacca tttcatggga aaatagtcta gaagatttga tggaagacga ggatttggtt     1680

gaggagctag aaaacgctga agaaactcaa aatgtggaaa ctaaacttct tgatgaagat     1740

ctagataaaa cattagagga aaataaggct ttcattagcc acgaggagaa aagaaaactg     1800

ttggacttaa tagaagactt gaaaaaaaaa ctgataaatg aaaaaaagga aaaattaacc     1860

ttggaattta aaattcgaga agaagttaca caggagttta ctcagtattg ggctcaacgg     1920

gaagctgact ttaaggagac tctgcttcaa gaacgagaga tattagaaga aaatgctgaa     1980

cgtcgtttgg ctatcttcaa ggatttggtt ggtaaatgtg acactcgaga agaagcagcg     2040

aaagacattt gtgccacaaa agttgaaact gaagaagcta ctgcttgttt agaactaaag     2100

tttaatcaaa ttaaagctga attagctaaa accaaaggag aattaatcaa aaccaaagaa     2160

gagttaaaaa agagagaaaa tgaatcagat tcattgattc aagagcttga gacatctaat     2220

aagaaaataa ttacacagaa tcaaagaatt aaagaattga taaatataat tgatcaaaaa     2280

gaagatacta tcaacgaatt tcagaaccta aagtctcata tggaaaacac atttaaatgc     2340

aatgacaagg ctgatacatc ttctttaata ataaacaata aattgatttg taatgaaaca     2400

gttgaagtac ctaaggacag caaatctaaa atctgttcag aaagaaaaag agtaaatgaa     2460

aatgaacttc agcaagatga accaccagca aagaaagggt ctatccatgt tagttcagct     2520

atcactgaag accaaaagaa aagtgaagaa gtgcgaccga acattgcaga aattgaagac     2580

atcagagttt tacaagaaaa taatgaagga ctgagagcat ttttactcac tattgagaat     2640

gaacttaaaa atgaaaagga agaaaaagca gaattaaata aacagattgt tcattttcag     2700

caggaacttt ctctttctga aaaaaagaat ttaactttaa gtaaagaggt ccaacaaatt     2760

cagtcaaatt atgatattgc aattgctgaa ttacatgtgc agaaaagtaa aaatcaagaa     2820

caggaggaaa agatcatgaa attgtcaaat gagatagaaa ctgctacaag aagcattaca     2880

aataatgttt cacaaataaa attaatgcac acgaaaatag acgaactacg tactcttgat     2940

tcagtttctc agatttcaaa catagatttg ctcaatctca gggatctgtc aaatggttct     3000

gaggaggata atttgccaaa tacacagtta gaccttttag gtaatgatta tttggtaagt     3060

aagcaagtta aagaatatcg aattcaagaa cccaataggg aaaattcttt ccactctagt     3120

attgaagcta tttgggaaga atgtaaagag attgtgaagg cctcttccaa aaaaagtcat     3180

cagattgagg aactggaaca acaaattgaa aaattgcagg cagaagtaaa aggctataag     3240

gatgaaaaca atagactaaa ggagaaggag cataaaaacc aagatgacct actaaaagaa     3300

aaagaaactc ttatacagca gctgaaagaa gaattgcaag aaaaaaatgt tactcttgat     3360

gttcaaatac agcatgtagt tgaaggaaag agagcgcttt cagaacttac acaaggtgtt     3420

acttgctata aggcaaaaat aaaggaactt gaaacaattt tagagactca gaaagttgaa     3480

tgtagtcatt cagccaagtt agaacaagac attttggaaa aggaatctat catcttaaag     3540

ctagaaagaa atttgaagga atttcaagaa catcttcagg attctgtcaa aaacaccaaa     3600

gatttaaatg taaaggaact caagctgaaa gaagaaatca cacagttaac aaataatttg     3660

caagatatga aacatttact tcaattaaaa gaagaagaag aagaaaccaa caggcaagaa     3720

acagaaaaat tgaaagagga actctctgca agctctgctc gtacccagaa tctgaaagca     3780

gatcttcaga ggaaggaaga agattatgct gacctgaaag agaaactgac tgatgccaaa     3840

aagcagatta agcaagtaca gaaagaggta tctgtaatgc gtgatgagga taaattactg     3900

aggattaaaa ttaatgaact ggagaaaaag aaaaaccagt gttctcagga attagatatg     3960

aaacagcgaa ccattcagca actcaaggag cagttaaata atcagaaagt ggaagaagct     4020

atacaacagt atgagagagc atgcaaagat ctaaatgtta aagagaaaat aattgaagac     4080

atgcgaatga cactagaaga acaggaacaa actcaggtag aacaggatca agtgcttgag     4140

gctaaattag aggaagttga aaggctggcc acagaattgg aaaaatggaa ggaaaaatgc     4200

aatgatttgg aaaccaaaaa caatcaaagg tcaaataaag aacatgagaa caacacagat     4260

gtgcttggaa agctcactaa tcttcaagat gagttacagg agtctgaaca gaaatataat     4320

gctgatagaa agaaatggtt agaagaaaaa atgatgctta tcactcaagc gaaagaagca     4380

gagaatatac gaaataaaga gatgaaaaaa tatgctgagg acagggagcg tttttttaag     4440

caacagaatg aaatggaaat actgacagcc cagctgacag agaaagatag tgaccttcaa     4500

aagtggcgag aagaacgaga tcaactggtt gcagctttag aaatacagct aaaagcactg     4560

atatccagta atgtacagaa agataatgaa attgaacaac taaaaaggat catatcagag     4620

acttctaaaa tagaaacaca aatcatggat atcaagccca aacgtattag ttcagcagat     4680

cctgacaaac ttcaaactga acctctatcg acaagttttg aaatttccag aaataaaata     4740

gaggatggat ctgtagtcct tgactcttgt gaagtgtcaa cagaaaatga tcaaagcact     4800

cgatttccaa aacctgagtt agagattcaa tttacacctt tacagccaaa caaaatggca     4860

gtgaaacacc ctggttgtac cacaccagtg acagttaaga ttcccaaggc tcggaagagg     4920

aagagtaatg aaatggagga ggacttggtg aaatgtgaaa ataagaagaa tgctacaccc     4980

agaactaatt tgaaatttcc tatttcagat gatagaaatt cttctgtcaa aaaggaacaa     5040

aaggttgcca tacgtccatc atctaagaaa acatattctt tacggagtca ggcatccata     5100

attggtgtaa acctggccac taagaaaaaa gaaggaacac tacagaaatt tggagacttc     5160

ttacaacatt ctccctcaat tcttcaatca aaagcaaaga agataattga aacaatgagc     5220

tcttcaaagc tctcaaatgt agaagcaagt aaagaaaatg tgtctcaacc aaaacgagcc     5280

aaacggaaat tatacacaag tgaaatttca tctcctattg atatatcagg ccaagtgatt     5340

ttaatggacc agaaaatgaa ggagagtgat caccagatta tcaaacgacg acttcgaaca     5400

aaaacagcca aataaatcac ttatggaaat gtttaatata aattttatag tcatagtcat     5460

tggaacttgc atcctgtatt gtaaatataa atgtatatat tatgcattaa atcactctgc     5520

atatagattg ctgttttata catagtataa ttttaattca ataaatgagt caaaatttgt     5580

atatttttat aaggcttttt tataatagct tctttcaaac tgtatttccc tattatctca     5640

gacattggat cagtgaagat cctaggaaag aggctgttat tctcatttat tttgctatac     5700

aggatgtaat aggtcaggta tttggtttac ttatatttaa caatgtctta tgaatttttt     5760

ttactttatc tgttatacaa ctgattttac atatctgttt ggattatagc taggatttgg     5820

agaataagtg tgtacagatc acaaaacatg tatatacatt atttagaaaa gatctcaagt     5880

ctttaattag aatgtctcac ttattttgta aacattttgt gggtacatag tacatgtata     5940

tatttacggg gtatgtgaga tgttttgaca caggcatgca atgtgaaata cgtgtatcat     6000

ggagaatgag gtatccatcc cctcaagcat ttttcctttg aattacagat aatccaatta     6060

cattctttag atcatttaaa aatatacaag taagttatta ttgattatag tcactctatt     6120

gtgctatcag atagtagatc attcttttta tcttatttgt ttttgtaccc attaaccatc     6180

cccacctccc cctgcaaccg tcagtaccct taccagccac tggtaaccat tcttctactc     6240

tgtatgccca tgaggtcaat tgattttatt tttagatccc ataaataaat gagaacatgc     6300

agtctt                                                                6306


<210> 370
<211> 3415
<212> DNA
<213> Homo sapiens

<400> 370
aggctggcat agcggctgcc gacccgccct cgttcctcca ccccctgaac gggactgctg       60

ggcccgcccc gccccgcctg caggtgaagc ggccgcagcc gccgagtagg tgcgtgggga      120

tgatctcact cgcgcgctcc gcgccaggag gaggaggagc gggagcggat ccaacttccg      180

ggtagtggag ccgcaagcca ccggcatctt gctttttctt ccccctcctc ctgtgtgccc      240

cgcgccgctc cctctttccc ttttattccc ggccccaccc gccaaaatga acagctcgga      300

cgaagagaag cagctgcagc tcattaccag tctgaaggag caagcaatag gcgaatatga      360

agaccttaga gcagagaacc agaaaacaaa ggagaagtgt gacaaaatta ggcaagaacg      420

agatgaagcc gttaaaaaac tggaagaatt tcagaaaatt tctcacatgg tcatagagga      480

agttaatttc atgcagaacc atcttgaaat agagaagact tgtcgagaaa gtgctgaagc      540

tttggcaaca aagctaaata aagaaaataa aacgttgaaa agaatcagca tgttgtacat      600

ggccaagctg ggaccagatg taataactga agagataaac attgatgatg aagattcgac      660

tacagacaca gacggtgccg ccgagacttg tgtctcagta cagtgtcaga agcaaattaa      720

agaacttcga gatcaaattg tatctgttca ggaggaaaag aagattttag ccattgagct      780

ggaaaatctc aagagcaaac tcgtagaagt aattgaagaa gtaaataaag ttaaacaaga      840

aaagactgtt ttaaattcag aagttcttga acagagaaaa gtcttagaaa aatgcaatag      900

agtgtccatg ttagctgtag aagagtatga ggagatgcaa gtaaacctgg agctggagaa      960

ggaccttcga aagaaagcag agtcatttgc acaagagatg ttcattgagc aaaacaagct     1020

aaagagacaa agccaccttc tgctgcagag ctccatccct gatcagcagc ttttgaaagc     1080

tttagacgaa aatgcaaaac tcacccagca acttgaagaa gagagaattc agcatcaaca     1140

aaaggtcaaa gaattagaag agcaactaga aaatgaaaca ctccacaaag aaatacacaa     1200

cctcaaacag caactggagc ttctagagga agataaaaag gaattggaat tgaaatatca     1260

gaattctgaa gagaaagcca gaaatttaaa gcactctgtt gatgaactcc agaaacgagt     1320

gaaccagtct gagaattcag tacctccacc acctcctcct ccaccaccac ttccccctcc     1380

acctcccaat cctatccgat ccctcatgtc catgatccgg aaacgatccc accccagtgg     1440

cagtggtgct aagaaagaaa aggcaactca accagaaaca actgaagaag tcacagatct     1500

aaagaggcaa gcagttgaag agatgatgga tagaattaaa aagggagttc atcttagacc     1560

cgttaatcag acagccagac cgaagacaaa gccagaatct tcgaaaggct gcgaaagtgc     1620

agtggatgaa ctaaaaggaa tactggcctc ccagtagcat tggatgcagg aaaaaataca     1680

ttgacggtga aaaacaagcc gaaccagttg tagttttaga tcctgtttct acacatgaac     1740

cccaaaccaa agaccaggtt gctgaaaaag atccaactca acacaaggag gatgaaggcg     1800

aaattcaacc agaaaacaaa gaagacagca ttgaaaacgt gagagagaca gacagctcca     1860

actgctgatc cataaaccag aagcctgaca tgtttggaag tccttttcaa taagcacatg     1920

attagtgttg ttatattggc aagggctgta gacattctgc tctggtcact gtattcagaa     1980

tacaggttct tttctggtgt cacttttgta agtagcaact ataaacataa gtaagctgtt     2040

tagcaaaaca cacattccta gtaggttttg gttttttgat ctttataaag atgaggtttt     2100

tttcctagtt actgtattaa gtatgacttc ttttagaagg ttacaaaaaa attcagatgt     2160

tgataccttt ttaggaaatg tgcataccac tcatcaaatg gaatgctgaa agtttgaggt     2220

gcttgtatat aatcggataa acaaaactga tcaacccaat gtgattttaa aagcccccaa     2280

agaagcttct gttttgggtc tgatcctctt gatggagaaa ctgcagcagc atggaaattg     2340

ttgggtactg tggcatacaa gttattttct acagtagact gagataaact gaaaactcag     2400

gagctggcat caaactcgta gtcccatagt cagtgttaat tacacacatt gttaactatt     2460

ggatgaaaaa tacatgctat tgattgtgtc caaagcctcc cgaggacctc cgtggggatg     2520

ctctggtagc ctgaatacag aactgaggtg aaagtccaaa ccttgaattt tacagtagta     2580

agttggtaaa ccatgtgctc tgtgctatga gttaattatg ttttcccaaa tactaatgtg     2640

gcacaagtac catattttat cagagttctt atgtacagta tggtgaagat aagtgacaag     2700

cacacatttt tcttgcttca ctgctgttct atattacaca ggtttgttgt tgtttttttt     2760

aaaaaagaaa ttaagcagta gttagtctct aaaaatacaa tgtttcaggc taccacagtg     2820

aataaataga aatgtaatca gggattaaaa aaaaaactta tgcagctttt caaagttgat     2880

tgtttcaaaa ttggtgttta tttaaaataa gtggtaatgt acttgaatgc actttttatg     2940

acaatgattc agtaatggta attttactat taaagaaagt gaaaggttta gttttgttag     3000

catggctcag catgtagctg tcaggtgttt ttcacctaag ggcaaaagaa aatgatagta     3060

ataattgcag tagttgtatt gtattgtatt tttgcacgtg tggtaagcat aggcttgaag     3120

aggtgggtag gcaggtacat gtacttccta aatttggaga taattatctt tctgtaagtt     3180

cgttatgctt gactgtttcc atgttctccc aataatgatt ttatagttac ttatcacttt     3240

actcatggag aattaaaacg taatgttttt caactgtatc tttctttaac tggataatac     3300

tgctatatga tatgcttact acagactgca ttaattcacg aaacgaattc tgttatgctg     3360

taatttgaac tctcctcacc acaacttatt aaaaaggcac caatagtttc ccatt          3415


<210> 371
<211> 1010
<212> DNA
<213> Homo sapiens

<400> 371
cggcctggcg cttccggcac cggccgaggt gcgggtcgcc tccagaggtg cgtggtcgtg       60

gcgcgaggga tcctgaggct gctccagcag tgcgccgccg ccgtctcctg gggcggcttg      120

ggttagccgg gaggtgggtc agaggctcgc cccgtgccct gcgtccgggc gtctccttag      180

ggcgcgtctt cgggtccggc cagcggtgct gaaaaaggga gaaggttggg ggtagggagg      240

aaacaagatc ccagttcaat agatttctcc gcagatcctg tgccttcaaa ccctacgagt      300

ccatacttta aaacaaaatg aagaaagtaa ggcttaagga actagagagt cgcctgcaac      360

aagtggatgg atttgaaaag cccaagctac ttctggaaca gtatcctacc aggccgcaca      420

ttgcagcatg tatgctctat acaatccata acacttatga tgacattgaa aataaagtcg      480

ttgcagatct aggatgtggt tgtggagtac ttagcatcgg aactgcaatg ttaggagcag      540

ggttgtgtgt tggatttgac atagatgaag acgcattgga aatatttaat aggaatgcag      600

aagagtttga gttaacaaat attgacatgg ttcaatgtga tgtgtgctta ttatctaaca      660

gaatgtccaa gtcattcgat acagtaatta tgaatcctcc ctttgggacc aaaaataata      720

aagggacaga tatggctttt ctaaagactg ctttggaaat ggcaagaaca gcagtatatt      780

ccttacacaa atcctcaact agagaacatg ttcaaaagaa agctgcagaa tggaaaatca      840

agatagatat tatagcagaa cttcgatatg acctgccagc atcatacaag tttcacaaaa      900

agaaatcagt ggacattgaa gtggacctaa ttcggttttc cttttaaaag ccccgcaaac      960

aaaagtcgtt taaaacctat ttaaaatgaa taaaaaattg gtttactaaa                1010


<210> 372
<211> 6926
<212> DNA
<213> Homo sapiens

<400> 372
atttgagcat cagttgaggg agaggacgct tcatttcctt tttggttggg aatgtgccgt       60

gaacatcctc tgctggagct tggggcctgg agcaaactgg ggctgcagat ttagacgtag      120

acgtttccga ggacgcgaga ctgcagagct ttgtaggcag ccaatcccag agaagcagac      180

gggatggcta gttcagcccg ggagcacctg ctttttgtga ggcgtcgaaa tccccagatg      240

cggtacacat tgagcccaga gaacctccag agccttgccg cccagagctc catgccagag      300

aacatgaccc tgcagcgggc caacagcgac accgacctgg tgacttctga gagccgctcc      360

agcttaactg ccagcatgta cgagtacacg ctggggcaag cccagaacct cattatcttc      420

tgggacatta aagaggaggt ggaccccagt gattggattg gactttatca tatagatgag      480

aattctccag ccaacttctg ggattctaag aacaggggtg tgactggaac acaaaaaggg      540

caaattgtat ggagaattga gcctgggccc tatttcatgg aaccggagat aaaaatctgt      600

tttaaatatt accacggcat tagtggagcc ctgcgagcca cgaccccctg catcaccgtg      660

aagaacccag ctgtgatgat gggggcagaa ggcatggagg gaggtgcttc aggaaacctg      720

cattctcgaa aacttgttag ctttacattg tcagatctta gggcagttgg gctaaagaaa      780

gggatgttct tcaatcctga cccttatctt aagatgtcaa ttcagccagg aaagaagagc      840

agtttcccca cctgtgccca ccacgggcag gagagacggt ctactatcat cagtaacacc      900

accaatccaa tttggcaccg agagaaatat tccttttttg cacttcttac tgatgtctta      960

gaaattgaaa ttaaagacaa atttgccaag agccgtccca tcatcaagcg ttttctgggg     1020

aaactaacca ttccagtcca gaggctgctg gagcgacaag ccatcggtga tcaaatgctc     1080

agctacaacc ttggcagaag gctcccagct gaccacgtga gtgggtacct ccagtttaaa     1140

gtggaggtta cgtcttctgt tcatgaagat gcctctccag aagctgttgg cacaatactt     1200

ggagtcaatt ctgtgaatgg agacttaggt agcccttccg atgacgagga catgccaggg     1260

agccatcacg acagccaggt gtgctctaat gggccagttt ctgaggacag tgctgccgat     1320

ggaaccccca agcattcatt caggactagc tccactctgg aaatagacac agaggaatta     1380

acctctacgt cttcaaggac ctcacctccc agaggacgtc aggattcact caatgattac     1440

ttagatgcta tcgaacacaa tggccactcc aggccgggga cagcgacctg ctctgagagg     1500

tccatgggtg cctctccgaa actgaggagt agttttccca ctgacacaag actcaatgcc     1560

atgcttcata ttgattcaga tgaagaagat cacgagttcc agcaagacct gggttaccca     1620

tcttccttgg aggaggaggg aggcctgatc atgtttagca gggcatccag agctgatgat     1680

ggaagcctga catctcagac aaagctggag gacaaccctg ttgagaatga ggaagcctcc     1740

acacacgaag ctgcttcctt tgaggataag ccagaaaatc ttccagagct tgcagagagc     1800

tccttacctg caggcccagc cccagaggaa ggtgaaggcg gcccagagcc tcaacccagt     1860

gctgaccagg gcagtgctga actgtgtggc tctcaagagg tagatcagcc cacaagtggc     1920

gcagacacag ggacttccga tgcatcagga ggaagccgaa gagccgtcag tgagaccgag     1980

tctctcgatc agggctctga gccttcccag gtgtcctctg aaacagaacc cagtgatcct     2040

gccaggacag agagtgtgag cgaagccagc accaggcctg agggagagag tgacctggaa     2100

tgcgctgaca gctcctgcaa tgagagtgtg accacgcagc tgtcctctgt ggacacacgg     2160

tgctcctctc ttgagagcgc acggtttcct gaaaccccag ccttttcttc tcaggaggag     2220

gaagacggag cctgtgcagc agagcccacc agcagtggcc ctgccgaagg gtcgcaggaa     2280

tccgtgtgca ctgctggttc tttacctgtg gtacaggtgc ccagtgggga ggatgaaggg     2340

ccaggggcag aatcggccac tgtacctgac caggaggagc tgggggaggt ctggcagcgg     2400

agggggagcc tggagggagc tgcagctgct gccgagagcc caccgcaaga agaaggcagt     2460

gctggggagg cccaaggcac ctgtgaaggg gcaactgccc aggaggaggg cgctactgga     2520

ggttctcaag ccaacggcca ccagccactg cgatcactac cttcagtgcg ccaggatgtt     2580

agccggtacc agagggtgga cgaggctctc ccaccaaact gggaggcacg cattgacagc     2640

cacggcagga tcttctacgt ggatcacgta aacagaacca cgacgtggca gcgaccgaca     2700

gctcccccag ccccgcaggt gctgcagaga tctaactcca tacagcaaat ggagcagctg     2760

aaccggcgat atcagagtat ccgcagaacc atgaccaatg agaggcctga ggaaaatacc     2820

aatgctattg atggggcagg ggaggaagct gactttcacc aagccagtgc agatttccga     2880

cgggagaaca tcctgcctca ctctacctcc agatccagga tcacgttgct gttacagtct     2940

ccccccgtga agttcctcat cagcccagag ttcttcaccg tgctgcattc taaccctagt     3000

gcctaccgca tgtttacaaa caacacgtgt ttgaagcaca tgatcaccaa agtccggagg     3060

gacacccacc actttgaacg ctaccagcat aaccgcgacc ttgtgggatt cctcaacatg     3120

ttcgcgaaca aacagctaga gctgccgcgg ggatgggaaa tgaaacatga tcaccagggc     3180

aaggcattct ttgtggacca caactcccgc accaccactt tcattgatcc ccggctccca     3240

cttcagagca gtagacccac aagtgcgctg gttcatcggc aacacctgac aaggcaacgc     3300

agccacagtg cgggtgaggt aggagaagat tctcgacatg caggaccacc agttcttccc     3360

aggccatcca gtacattcaa tacagtcagt aggccacagt accaggacat ggttccagtg     3420

gcttacaatg acaagattgt tgcatttcta cgtcaaccca atatctttga aattctacag     3480

gagcgtcaac ctgatcttac caggaatcac tcactcaggg agaagatcca atttatccga     3540

actgaaggga ctccaggatt ggtgcgcctt tcaagcgatg cagaccttgt tatgttgctg     3600

agcttatttg aagaagagat aatgtcgtat gtgcctccac atgccttact ccaccccagc     3660

tactgtcagt ccccacgtgg ctctcccgtg tcatctcctc agaactcgcc aggtacccag     3720

cgtgccaatg cccgggctcc agccccttac aagcgggatt tcgaagccaa actgaggaac     3780

ttttacagga agttagagac taaaggatat ggacaaggcc cagggaagtt aaagttaatt     3840

atccgaagag atcacttact agaagatgct tttaatcaga ttatgggcta ctccagaaaa     3900

gacctgcaga gaaataagct atatgtcacc ttcgttgggg aggaagggct ggattacagt     3960

gggccttcta gagagttttt cttcctggta tccagagaac tctttaaccc atattatggc     4020

ttatttgaat attcagccaa tgacacatac acagtacaaa taagtcctat gtctgctttt     4080

gtagacaatc accatgaatg gttccgattc agtggtagga tccttggtct tgcactaata     4140

caccagtatt tgttggatgc cttcttcaca cggccctttt ataaggctct tctcagaatt     4200

ctatgtgacc tgagtgacct agaatacctt gatgaagagt tccatcagag cctgcagtgg     4260

atgaaagaca atgatatcca tgacatccta gacctcacgt tcactgtgaa cgaagaagta     4320

tttgggcaga taactgaacg agaattaaag ccagggggtg ccaatatccc agttacagag     4380

aagaacaaga aggagtacat cgagaggatg gtgaagtgga ggattgagag gggtgttgta     4440

cagcaaacag agagcttagt gcgtggcttc tatgaggtgg tggatgccag gctggtatct     4500

gtttttgatg caagagaact ggaattggtc atcgcaggca cagctgaaat agacctaagt     4560

gattggagaa acaacacaga atatagagga ggataccatg acaatcatat tgtaattcgg     4620

tggttctggg ctgcagtgga aagattcaac aatgaacaac gactaaggtt gttacagttt     4680

gttacaggca catccagcat tccctatgaa ggatttgctt cactccgagg gagtaacggc     4740

ccaagaagat tctgtgtgga gaaatggggg aaaatcactg ctcttcccag agcgcataca     4800

tgttttaacc gtctggatct gcctccctac ccatcctttt ccatgcttta tgaaaaactg     4860

ttgacagcag ttgaagaaac cagtactttt ggacttgagt gacctggaag ctgaatgccc     4920

atctctgtgg acaggcaggt tcagaagctg ccttctagaa gaatgattga acattggaag     4980

tttcaagagg atgcttcctt taggataaag ctatgtgctg ttgttttcca ggaacaagtg     5040

ctctgtcaca tttggggact ggagatgagt cctcttggaa ggatttgggt gagcttgatg     5100

cccagggaac aacccaaccg tctttcaatc aacagttctt gactgccaaa ctttttccat     5160

ttgttatgtt ccaagacaaa gatgaaccca tacatgatca gctccacggt aatttttagg     5220

gactcaggag aatcttgaaa cttacccttg aacgtggttc aagccaaact ggcagcattt     5280

ggcccaatct ccaaattaga gcaagttaaa taatataata aaagtaaata tatttcctga     5340

aagtacattc atttaagccc taagttataa cagaatattc atttcttgct tatgagtgcc     5400

tgcatggtgt gcaccatagg tttccgcttt catgggacat gagtgaaaat gaaaccaagt     5460

caatatgagg tacctttaca gatttgcaat aagatggtct gtgacaatgt atatgcaagt     5520

ggtatgtgtg taattatggc taaagacaaa ccattattca gtgaattact aatgacagat     5580

tttatgcttt ataatgcatg aaaacaattt taaaataact agcaattaat cacagcatat     5640

caggaaaaag tacacagtga gttctgttta ttttttgtag gttcattatg tttatgttct     5700

ttaagatgta tataagaacc tacctatcat gctgtatgta tcactcattc cattttcatg     5760

ttccatgcat actcgggcat catgctaata tgtatccttt taagcactct caaggaaaca     5820

aaagggcctt ttatttttat aaaggtaaaa aaaattcccc aaatattttg cactgaatgt     5880

accaaaggtg aagggacatt acaatatgac taacagcaac tccatcactt gagaagtata     5940

atagaaaata gcttctaaat caaacttcct tcacagtgcc gtgtctacca ctacaaggac     6000

tgtgcatcta agtaataatt ttttaagatt cactatatgt gatagtatga tatgcattta     6060

tttaaaatgc attagactct cttccatcca tcaaatactt tacaggatgg catttaatac     6120

agatatttcg tatttccccc actgcttttt atttgtacag catcattaaa cactaagctc     6180

agttaaggag ccatcagcaa cactgaagag atcagtagta agaattccat tttccctcat     6240

cagtgaagac accacaaatt gaaactcaga actatatttc taagcctgca ttttcactga     6300

tgcataattt tcttattaat attaagagac agtttttcta tggcatctcc aaaactgcat     6360

gacatcacta gtcttacttc tgcttaattt tatgagaagg tattcttcat tttaattgct     6420

tttgggatta ctccacatct ttgtttattt cttgactaat cagattttca atagagtgaa     6480

gttaaattgg gggtcataaa agcattggat tgacatatgg tttgccagcc tatgggttta     6540

caggcattgc ccaaacattt ctttgagatc tatatttata agcagccatg gaattcctat     6600

tatgggatgt tggcaatctt acattttata gaggtcatat gcatagtttt cataggtgtt     6660

ttgtaagaac tgattgctct cctgtgagtt aagctatgtt tactactggg accctcaaga     6720

ggaataccac ttatgttaca ctcctgcact aaaggcacgt actgcagtgt gaagaaatgt     6780

tctgaaaaag ggttatagaa atctggaaat aagaaaggaa gagctctctg tattctataa     6840

ttggaagaga aaaaaagaaa aacttttaac tggaaatgtt agtttgtact tattgatcat     6900

gaatacaagt atatatttaa ttttgc                                          6926


<210> 373
<211> 2133
<212> DNA
<213> Homo sapiens

<400> 373
cttccgagtt accgccgccg tcgccgccgc tcctcctctc ccggtcctgg gtttccttgg       60

cgctgcggcc gccgctccct ctgcgacctg tatgaggagg aggaggagga ggatgtgaag      120

atggcggagc tgcagatgct gctggaagag gaaatcccgg ggggccgccg ggccctcttc      180

gacagctaca caaatctgga acgggtggcc gattactgcg agaacaacta catacagtca      240

gcagataagc agagagccct agaagaaacc aaagcctaca ccacccaatc cttagcaagt      300

gttgcctatc tgataaacac cttggccaac aatgtcctgc agatgctgga tatccaggca      360

tcccagctac gaaggatgga atcttcaatc aatcatattt cacaagcaaa ttagaggcgt      420

tgatcttgag tcgacttttg tgaccaaatt tggaaacaat tgcagtttga gattgaatga      480

gacagttgat attcataaag agaaagttgc aagaagagaa attggtattt tgactaccaa      540

taaaaacact tcaaggacac ataagattat tgctccagcc aaccttgaac gaccagttcg      600

ttatattaga aaacctattg actatacaat tctagatgat attggacatg gagtaaaggt      660

gagtacccag aacatgaaga tgggtgggct gccgcgtaca acacctccaa ctcagaagcc      720

ccctagtccc cctatgtcag ggaaagggac acttgggcgg cactccccct atcgcacact      780

ggagccagtg cgtcctccag tggtaccaaa tgattacgta cctagcccaa cccgtaatat      840

ggctccctcg cagcagagcc ctgtgaggac agcttctgtg aatcaaagaa atcgaactta      900

cagcagcagt gggagtagtg gagggagcca cccaagtagt cggagcagca gtcgagagaa      960

cagtggaagt ggtagtgtgg gggttcctat tgctgttcct actccatctc ctcccagtgt     1020

ctttccaggt catcctgtac agttctacag catgaatagg cctgcctctc gccatactcc     1080

cccaacaata gggggctcgt tgccctatag acgccctcct tccattactt cacaaacaag     1140

ccttcagaat cagatgaatg gaggaccttt ttatagccag aatccagttt cagatacacc     1200

acctccaccg ccacctgtgg aagaaccagt ctttgatgag tctcccccac ctcctcctcc     1260

tccagaagat tacgaagagg aggaagctgc tgtggttgag tatagtgatc cttatgctga     1320

agaggaccca ccgtgggctc cacgttctta cttggaaaag gttgtggcaa tttatgacta     1380

tacaaaagac aaggaagatg agctgtcctt tcaggaagga gccattattt atgtcatcaa     1440

gaagaatgac gatggttggt atgagggagt tatgaatgga gtgactgggc tttttcctgg     1500

gaattacgtt gagtctatca tgcattattc tgagtaaagc tcagcagggc tgtgcttgcc     1560

tcacaggaat agtcaggtct tcccagatta tctgaaggcc ctggggattc cactccagta     1620

aagtagaatg aaggatacaa atgataaaaa ttacactttt ttttttggtt tattccccag     1680

tattaaaaac aaagcaagct gagtctgaac aaatggatct ttctgccatc atttgtacaa     1740

tgctgagctg tctggattga aataaaatga ccatttttat gtatgtcaaa ggtataacag     1800

cataactgtg tagccaaaac aaaatcagat taagactgat tcagaaaaat ctgggatctt     1860

tctcaggaat actgtatacc cttgggattt ctcctcctgc agaatctgtg gcattggatg     1920

ttcttcattg cctgtgctaa ggggttaacc tcatggccca gtgggtaccc tagccccttc     1980

ttttcttcca cttgtatgaa gaggagggaa ccaacattta aataccacac ttaaccattt     2040

ttacaattat ttcagatggc ttttttcctc tgtgacactg taaattctgc attctctcag     2100

cacttgagtg caccaaacga gtgaatgctg aac                                  2133


<210> 374
<211> 6484
<212> DNA
<213> Homo sapiens

<400> 374
gcgcgtgcgc gcgcccggcc ggccgtcgcc gcggtgaccg tcctcggagt ccgtcggctc       60

gcgccccgcc cccgtcgccc cctcccctgt cgcgcgctgg ggctgtttct cgctccttcc      120

gagttaccgc cgccgtcgcc gccgctcctc ctctcccggt cctgggtttc cttggcgctg      180

cggccgccgc tccctctgcg acctgtatga ggaggaggag gaggaggatg tgaagatggc      240

ggagctgcag atgctgctgg aagaggaaat cccggggggc cgccgggccc tcttcgacag      300

ctacacaaat ctggaacggg tggccgatta ctgcgagaac aactacatac agtcagcaga      360

taagcagaga gccctagaag aaaccaaagc ctacaccacc caatccttag caagtgttgc      420

ctatctgata aacaccttgg ccaacaatgt cctgcagatg ctggatatcc aggcatccca      480

gctacgaagg atggaatctt caatcaatca tatttcacaa acagttgata ttcataaaga      540

gaaagttgca agaagagaaa ttggtatttt gactaccaat aaaaacactt caaggacaca      600

taagattatt gctccagcca accttgaacg accagttcgt tatattagaa aacctattga      660

ctatacaatt ctagatgata ttggacatgg agtaaaggtg agtacccaga acatgaagat      720

gggtgggctg ccgcgtacaa cacctccaac tcagaagccc cctagtcccc ctatgtcagg      780

gaaagggaca cttgggcggc actcccccta tcgcacactg gagccagtgc gtcctccagt      840

ggtaccaaat gattacgtac ctagcccaac ccgtaatatg gctccctcgc agcagagccc      900

tgtgaggaca gcttctgtga atcaaagaaa tcgaacttac agcagcagtg ggagtagtgg      960

agggagccac ccaagtagtc ggagcagcag tcgagagaac agtggaagtg gtagtgtggg     1020

ggttcctatt gctgttccta ctccatctcc tcccagtgtc tttccaggtc atcctgtaca     1080

gttctacagc atgaataggc ctgcctctcg ccatactccc ccaacaatag ggggctcgtt     1140

gccctataga cgccctcctt ccattacttc acaaacaagc cttcagaatc agatgaatgg     1200

aggacctttt tatagccaga atccagtatc tcttgctcct cctcctccct ccatcctaca     1260

ggtaactcct cagttacctt taatgggatt tgtggccaga gtccaagaaa atatttcaga     1320

tacaccacct ccaccgccac ctgtggaaga accagtcttt gatgagtctc ccccacctcc     1380

tcctcctcca gaagattacg aagaggagga agctgctgtg gttgagtata gtgatcctta     1440

tgctgaagag gacccaccgt gggctccacg ttcttacttg gaaaaggttg tggcaattta     1500

tgactataca aaagacaagg aagatgagct gtcctttcag gaaggagcca ttatttatgt     1560

catcaagaag aatgacgatg gttggtatga gggagttatg aatggagtga ctgggctttt     1620

tcctgggaat tacgttgagt ctatcatgca ttattctgag taaagctcag cagggctgtg     1680

cttgcctcac aggaatagtc aggtcttccc agattatctg aaggccctgg ggattccact     1740

ccagtaaagt agaatgaagg atacaaatga taaaaattac actttttttt ttggtttatt     1800

ccccagtatt aaaaacaaag caagctgagt ctgaacaaat ggatctttct gccatcattt     1860

gtacaatgct gagctgtctg gattgaaata aaatgaccat ttttatgtat gtcaaaggta     1920

taacagcata actgtgtagc caaaacaaaa tcagattaag actgattcag aaaaatctgg     1980

gatctttctc aggaatactg tatacccttg ggatttctcc tcctgcagaa tctgtggcat     2040

tggatgttct tcattgcctg tgctaagggg ttaacctcat ggcccagtgg gtaccctagc     2100

cccttctttt cttccacttg tatgaagagg agggaaccaa catttaaata ccacacttaa     2160

ccatttttac aattatttca gatggctttt ttcctctgtg acactgtaaa ttctgcattc     2220

tctcagcact tgagtgcacc aaacgagtga atgctgaact cacttgcatc ccttcatgtt     2280

tctgtttgtg gattataagg atgatgaaat gtgaaagtct cccaacactc tgagggtggt     2340

gaacgattgc cacccgtttg attttaatgt gctgctgcat gagactgcat tgttgctaat     2400

ggccagtgta cccagatgtg aagtgtggta ggctggttca tatgtggagg tgggtgtgtg     2460

aagctagaca cgaaggtccc taaggttctg aagagacttg aactgtggaa atgctcttag     2520

caggcatccc gaacccctgc ttcggtgctg ttttgaggag taggatcttg gagttcagac     2580

caactatgac tatcatttcc ttcactatct agaaaaacgc tattctactt tggaagagaa     2640

tagtagttat tttcaagtct cctgacagtc actgggagta caaggtttgc taatgtgctc     2700

tctggacgtt attaatggcc agtattagtt gctgctgtat tactgactcg cttagctgta     2760

gaaagggtaa tactctcctg attttgtatg attggactct taagtagctg ctgttagtca     2820

gaattaaaac ccatctcaga ctaagaatat aatgaataag attaataggc caaaatatgt     2880

atctaatcac attgataaaa attaatataa ctgacacaat aaaacacatt tcccccatct     2940

gtacaataaa tacagcttca aattcagtgg agtctgtagg gcagataact ttaatcatca     3000

ctactgtagt cagtataaga aatgctgaaa aaaatccagg agggcttgtc tctttgtggg     3060

tggtcactgt gatgttgggc cagctcctgt tcaggtccag agctgctaac gtgggttcta     3120

ctcagtccca gtgacttggc cagaatagag ctttgccagg taactgccct gtgctaggtg     3180

aaaggggaaa agcagtagct ggatatattt caaatgaggt tttgaacaag ttcagaaagt     3240

ggaacttgat tgaaaagtga acaagtgtag tagtgtgtga gaaaattcag atggtgtcgg     3300

atgcagaagt taatattcca cttaatgtta tctgagcatt aaaaatcatc agcatttaac     3360

tgagacccca ctatagagtt tccttatcaa gactttttgg ttttaaagtt gtttttaatg     3420

cattgcaagt tacaatagct attttgcttt tagatttttc ccagcacttt gtatttatta     3480

gctttcatta acttgcctcc agtatacatt ccacttcgtg cttttcttag gtcatttcta     3540

catcccttat tccttgtttt cctgcagtgt aatggccctg aatgtcctct gagccttcag     3600

ctccattatg gacccaaact agactatact tggataagtt aagctcttct tcgtgtactg     3660

gtctataatt agaaaaactg ttttaaatta gatgttccca ttatttattt aaacagcttt     3720

ttgctgagaa agcttagtgg attaatgagg cagagggtgt tttgaaatcc aataaatagt     3780

tcccacaggc tgggtgtggt ggcttatgcc tgtaatccca gcactttcgg aggccgaggt     3840

gggtggatca tgaggtcaat aaattgagac catcctggcc aacatggtga aaccccatct     3900

ctactaaaaa cacaaaaatt agctgggcgt ggtggcgcac acctgtagtc ccagctactt     3960

gggaggctga ggcaggagaa tcactggaac ctgggaggca gaggttgcag tgagccgaga     4020

ttgtgccact gcactccagc ctggtgacag agcgagactc catcaaaaaa aaaaaaaaaa     4080

agttcccaca gctcaccact acagaagcag ggaagacaac tatgcagaaa acagagttag     4140

tggcggtcag caggaatgca gctggtcttt tggaccccta cgggatgggg gcagtgcaga     4200

agacactggt gaagtccttt atactgaaga cctgtggttg ggagcagggg tagtccatgg     4260

gtctgctgat tttttttccc tatttagtac taatgtgtgt gtgatctttg ttttacaaac     4320

agtacctttt gggttttctg catattttat aatttttgta cagttttgaa ttctatagat     4380

tgtcttggaa ggatactgtg tgatgggtca ggcacacagt aattggagac ttttaatgta     4440

tgtaatattt catagattgc atgctattaa tcatctgtga gggtagtatt ttttgtttta     4500

ttgtaagttt ccctcttttt ttataaatta aaagatggtt ggtattagga atttcaaatg     4560

aatgcagaaa atcttacatg ctgtgtacta ttaatattat aacagacgat ccaagtccaa     4620

aatctgacca ataaagcaac cattttatca agatagaggg attctaatgg gagaggggat     4680

tcttccctcc tgaagtttgt gtgtccagtc cccttaaaaa aaatgaatag ttgtcttttc     4740

ttgtcatatt aatactcgaa agtccatggt ggtattaatg aaagtacact ttattgttgc     4800

ctttgaactt acggccaagg caataaatca gaaacaaaaa tagtgccaat gtgtcaaaat     4860

cgacatctga gagattcagc ctcccatttg gaataaatat gaatcttcta agctatcttg     4920

tttaatattt tccatcattt agctacttcc tatctccctc agaggcgcct gctgttccca     4980

ttttagagtt gacagtggcc tgctaatttt gctatgttcc taaaagttac tgggtgtgag     5040

acattttcat cccctccttt ttcctactgc tggtgtttat tatccagcta gacaatattt     5100

tatgcatatt taccgtgatg tctggaccgt acctgtgctc cttggcagtt tatgttgaag     5160

ataactaaag atttttctct ttgggaggca tcaaaatgat ggtagtttgc ttttatcttt     5220

ttatgttcat tttcttttag taggtgacct ttctgcatta agaactgttt ttatctttta     5280

ctaccttttc ttttctcctt tgtggagaca gcatgacatg tcctgaaggt cacctttgcc     5340

tttgaaaaag gtttgatgga ggaattcaca ggtgactgac aagtctttga aaagaatggg     5400

atctgctcac ttctggtctt tttggccggg aactcctgat tggtgttaag gtggtaattt     5460

cccccatata agatttagaa tcactgagtt tgagctagat gaaattttta aaatttctgg     5520

ttgtctcatt agactgatga ggtgagtttt cttcttcata tgaacagcta gttaataaca     5580

gcagagttct cactcagtgc tcagtactta attttccact gcaccacaac tgtcttaact     5640

aaatgtgctg tatttttctt taaaagttaa gagttctatt tggtgttttc aggaatatac     5700

gtgaaaagac atgccatgtt ttggtaaata ccatcagagt tgtgtaaagg cgtgtactaa     5760

gtgcaatctt aatttgtgga aataatcttc atttacccct cctaaaacta cactcagtat     5820

aaacactttc ccataaggtg tgtgcagtaa aaatgttata ttactccaac actggcagga     5880

gcacagcaca gcagccttat tggagagagc cttataaaag tgattaaatg gaggcattga     5940

gctcattacc tttaagttta ctttgtgctg acctttgttc ctgttttgag aatctcatat     6000

aattattaaa aaaaaaaaac aattaaaacg aaacggcggg gcctagctgt gtataaatga     6060

tccttgctga atatcttaag gttttttgta agaaaaaaga aaaaccaaca aaaaaagctt     6120

attttcacat taaaatgaaa cctcttttgc aacttaagaa ttctatggaa aagcagtttt     6180

tatcatattt tgtgtccatg caccattttt cttaaaatgg cttacaaaaa agaatgtaaa     6240

caatttgtga tctggccagt tgtactttta gctcccagag ggagagttgg tggtattatg     6300

agttgagtaa aaaccatcca ggggaacttg agggagcagt ctgttgccag taatgttcct     6360

tgtgtgccat taaaccacct ccagatgagt ggaggaacat cactttttaa ttttttaatt     6420

gtatttggaa ttgttgccgt gtactaagaa cttgacctaa ataaaatccc acaaagtata     6480

ttca                                                                  6484


<210> 375
<211> 2237
<212> DNA
<213> Homo sapiens

<400> 375
atttatgcat taagtggttg cttagattta aggtgagtac ccagaacatg aagatgggtg       60

ggctgccgcg tacaacacct ccaactcaga agccccctag tccccctatg tcagggaaag      120

ggacacttgg cagcagtggg agtagtggag ggagccaccc aagtagtcgg agcagcagtc      180

gagagaacag tggaagtggt agtgtggggg ttcctattgc tgttcctact ccatctcctc      240

ccagtgtctt tccagcccct gctggctctg ctggcactcc tccccttcct gctacttctg      300

catctgcccc tgctcctctt gttcctgcta ctgtcccttc ctccactgcc ccagacgctg      360

ctgctggggg tgcccagacc cttgctgatg gcttcacttc tccaactccc cctgttgttt      420

cttccactcc ccctacaggt catcctgtac agttctacag catgaatagg cctgcctctc      480

gccatactcc cccaacaata gggggctcgt tgccctatag acgccctcct tccattactt      540

cacaaacaag ccttcagaat cagatgaatg gaggaccttt ttatagccag aatccagttt      600

cagatacacc acctccaccg ccacctgtgg aagaaccagt ctttgatgag tctcccccac      660

ctcctcctcc tccagaagat tacgaagagg aggaagctgc tgtggttgag tatagtgatc      720

cttatgctga agaggaccca ccgtgggctc cacgttctta cttggaaaag gttgtggcaa      780

tttatgacta tacaaaagac aaggaagatg agctgtcctt tcaggaagga gccattattt      840

atgtcatcaa gaagaatgac gatggttggt atgagggagt tatgaatgga gtgactgggc      900

tttttcctgg gaattacgtt gagtctatca tgcattattc tgagtaaagc tcagcagggc      960

tgtgcttgcc tcacaggaat agtcaggtct tcccagatta tctgaaggcc ctggggattc     1020

cactccagta aagtagaatg aaggatacaa atgataaaaa ttacactttt ttttttggtt     1080

tattccccag tattaaaaac aaagcaagct gagtctgaac aaatggatct ttctgccatc     1140

atttgtacaa tgctgagctg tctggattga aataaaatga ccatttttat gtatgtcaaa     1200

ggtataacag cataactgtg tagccaaaac aaaatcagat taagactgat tcagaaaaat     1260

ctgggatctt tctcaggaat actgtatacc cttgggattt ctcctcctgc agaatctgtg     1320

gcattggatg ttcttcattg cctgtgctaa ggggttaacc tcatggccca gtgggtaccc     1380

tagccccttc ttttcttcca cttgtatgaa gaggagggaa ccaacattta aataccacac     1440

ttaaccattt ttacaattat ttcagatggc ttttttcctc tgtgacactg taaattctgc     1500

attctctcag cacttgagtg caccaaacga gtgaatgctg aactcacttg catcccttca     1560

tgtttctgtt tgtggattat aaggatgatg aaatgtgaaa gtctcccaac actctgaggg     1620

tggtgaacga ttgccacccg tttgatttta atgtgctgct gcatgagact gcattgttgc     1680

taatggccag tgtacccaga tgtgaagtgt ggtaggctgg ttcatatgtg gaggtgggtg     1740

tgtgaagcta gacacgaagg tccctaaggt tctgaagaga cttgaactgt ggaaatgctc     1800

ttagcaggca tcccgaaccc ctgcttcggt gctgttttga ggagtaggat cttggagttc     1860

agaccaacta tgactatcat ttccttcact atctagaaaa acgctattct actttggaag     1920

agaatagtag ttattttcaa gtctcctgac agtcactggg agtacaaggt ttgctaatgt     1980

gctctctgga cgttattaat ggccagtatt agttgctgct gtattactga ctcgcttagc     2040

tgtagaaagg gtaatactct cctgattttg tatgattgga ctcttaagta gctgctgtta     2100

gtcagaatta aaacccatct cagactaaga atataatgaa taagattaat aggccaaaat     2160

atgtatctaa tcacattgat aaaaattaat ataactgaca caataaaaca catttccccc     2220

atctgtacaa taaatac                                                    2237


<210> 376
<211> 2749
<212> DNA
<213> Homo sapiens

<400> 376
aagcggcgct aagagaaggc gggacagagg aatgggaaat gacgtgagga gtgcggaggg       60

gcgcgaggtt tcaagatggc ggtagctgag gggttgaccg agagacccag ttgaaggcct      120

ttacgaagtg aaagaggccg ggagtcgccc cctacccgct tctcgtagtc ctgggagcac      180

agcagaagtg tttttctttt tttaatgaac aagtaaacca tacaaattgt caacatggga      240

cggagatcta catcatccac caagagtgga aaatttatga accccacaga ccaagcccga      300

aaggaagccc ggaagagaga attaaagaag aacaaaaaac agcgcatgat ggttcgagct      360

gcagttttaa agatgaagga tccaaaacag ataatccgag acatggagaa attggatgaa      420

atggagttta acccagtgca acagccacaa ttaaatgaga aagtactgaa agacaagcgt      480

aaaaagctgc gtgaaacctt tgaacgtatt ctacgactct atgaaaaaga gaatccagat      540

atttacaaag aattgagaaa gctagaagta gaatatgaac agaagagggc tcaacttagc      600

caatattttg atgctgtcaa gaatgctcag catgtggaag tggagagtat tcctttgcca      660

gatatgccac atgctccttc caacattttg atccaggaca ttccacttcc tggtgcccag      720

ccaccctcta tcctaaagaa aacctcagcc tatggacctc caactcgggc agtttctatc      780

cttcctcttc ttggacatgg tgttccacgt ttgccccctg gcagaaaacc tcctggccct      840

ccccctggtc cacctcctcc tcaagtcgtg cagatgtatg gccgtaaagt gggttttgcc      900

ctagatcttc cccctcgtag gcgagatgaa gacatgttat atagtcctga acttgcccag      960

cgaggtcatg atgatgatgt ttctagcacc agtgaagatg atggctatcc tgaggacatg     1020

gatcaagata agcatgatga cagtactgat gacagtgaca ccgacaaatc agatggagaa     1080

agtgacgggg atgaatttgt gcaccgtgat aatggtgaga gagacaacaa tgaagaaaag     1140

aagtcaggtc tgagtgtacg gtttgcagat atgcctggaa aatcaaggaa gaaaaagaag     1200

aacatgaagg aactgactcc tcttcaagcc atgatgcttc gtatggcagg tcaagaaatc     1260

cctgaggagg gacgggaagt agaggaattt tcagaggacg atgatgaaga tgattctgat     1320

gactctgaag cagaaaagca atcacaaaag cagcataaag aggaatccca ttctgatggc     1380

acatccactg cttcttcaca gcagcaggct ccgccgcagt ctgttcctcc ttctcagata     1440

caagcacctc ccatgccagg accaccacct cttggaccac cacctgctcc accattacgg     1500

cctcctgggc cacctacagg ccttcctcct ggtccacctc caggagctcc tccattcctg     1560

agaccacctg gaatgccagg actccgaggg cccttacccc gacttttacc tccaggacca     1620

ccaccaggcc gaccccctgg ccctccccca ggtccacctc caggtctgcc tcctggtccc     1680

cctcctcgtg gacccccacc aaggctacct ccccctgcac ctccaggtat tcctccacct     1740

cgtcctggca tgatgcgccc acctttggtg cctccccttg gacctgcccc ccctgggctg     1800

ttcccaccag ctcccttgcc aaaccctggg gttttaagtg ccccacccaa cttgattcag     1860

cgacccaagg cggatgatac aagtgcagcc accattgaga agaaagccac agcaaccatc     1920

agtgccaagc cacagatcac taatcccaag gcagagatta ctcgatttgt gcccactgca     1980

ctgagagtac gtcgggagaa taaaggggct actgctgctc cccaaagaaa gtcagaggat     2040

gattctgctg tgcctcttgc caaagcagca cccaaatctg gtccttctgt tcctgtctca     2100

gtacaaacta aggatgatgt ctatgaggct ttcatgaaag agatggaagg gctactgtga     2160

cagcttttga tgccagaaaa ggcttctgtt cacaacagtg gcccatggag aaagaggctc     2220

ttattaaact tagatgaaag agctgcttcc attgtcaggg tattttctaa tttcagttca     2280

aggaatatcc taaaatttag ccttgttcag aatttactgc acataaaaaa gggtatttca     2340

tccagaatag atcagttatt gaagcagtgc tgctaacatc cattcccttt cataccacca     2400

ttttcaccct gtttcttccc ctcctccagt tctttggaaa tttgtgatcg ggggatctta     2460

gttgcttatt tgttttgact cttgtgtgct gtgggcactg gagtagagat ttctggagaa     2520

aaaaaaacag tttatttcat cttgcctttt gtgtttgagt tatttttaat attttcctgt     2580

aaatattttg taatatttta cttgtaatga aatggatcac aatgtcattt cctaatacaa     2640

ggcaggatat gtgggaagaa tatgtacaat tatttgatta aaattatttc ccactgacct     2700

aaactttcag tgatttgtgg gaaaaataaa taaatgttct acaccaaga                 2749


<210> 377
<211> 4807
<212> DNA
<213> Homo sapiens

<400> 377
ggttattgtt gctcctgtgg ccattctctt gtcatcccca ctttcacatt ttggcgtggt       60

gtattaatag actgagtggg attaatgggt aaatatgact ttatagtcag ctctaatcct      120

ggattcaata tcagaattta gattttcagc tttgtggatg ttcgacattt taaaaacagt      180

tattgcaaag aggtgaaaat tttgttctga agtcttaagg aaacagagaa agtttttccg      240

tccttaagtg tgggacttgt tttgtgacca acaatatgaa aggctctgag gtcagcttgg      300

agaagaaaaa aaagattaag atgccagtga agagacttcg tgaggtagtt tctcaaaatc      360

atggagatca tttggttttg ctgaaagatg agttgccctg tgttcctccg gcattgtctg      420

caaataaacg tcttcctgtt ggaacgggga ctagtttgaa tggaacatca cgtggttcat      480

cagacttaac ttctgctaga aattgttacc agcctctatt agaaaatccc atggtgtcag      540

aaagtgattt ttctaaagac gttgcagtgc aagtgttgcc tttggataaa atagaagaga      600

acaacaagca aaaagcaaat gacatcttca tttctcagta tacaatggga cagaaagatg      660

ctctaagaac agttttaaag caaaaagctc aaagcatgcc tgtttttaag gaagtaaagg      720

tacatctgtt agaagatgca ggcatagaga aggatgctgt tactcaggag actagaattt      780

cacccagtgg aattgattca gctacaaccg tggctgcagc aactgctgct gccattgcaa      840

ccgcagctcc gttgataaag gtgcagagtg atttggaagc aaaagtcaat tctgttacag      900

aattacttag taaattacag gagactgata aacacctgca acgtgttaca gagcagcaaa      960

caagcattca gaggaaacaa gagaaattac attgtcatga tcacgaaaag caaatgaatg     1020

tgtttatgga gcagcacata aggcatcttg aaaagttaca acaacaacaa atagatattc     1080

agactcattt tattagtgct gcactcaaga ctagtagttt tcagcctgtt agtatgccct     1140

cctccagagc agtggaaaag tattccgtaa aaccagaaca ccctaatctt ggtagctgta     1200

atccatcttt atataacaca tttgcttcca aacaagcacc tttaaaagaa gttgaagata     1260

cgagttttga taaacagaaa tctcctttgg agacaccagc acctcgcaga tttgctcctg     1320

tacctgtttc aagggatgat gaactatcaa agagggaaaa tcttttggaa gaaaaagaaa     1380

atatggaagt gtcgtgtcac agaggaaatg taagactatt ggaacaaatt ttgaataata     1440

atgattcttt gacaagaaaa agtgaatcat caaacaccac ctcactaact aggtcaaaaa     1500

taggatggac tcctgagaaa acaaacagat ttccttcctg tgaagagcta gaaacaacta     1560

aagtgactat gcagaagtct gatgatgttc ttcatgacct tggccaaaaa gagaaagaaa     1620

caaatagcat ggtccagcca aaagaatctc tgagtatgtt gaagcttcca gatcttccac     1680

agaattctgt taagcttcaa acaaccaata caacaagatc tgtattgaaa gatgctgaga     1740

agattttgag aggagtacaa aacaataaaa aagtacttga agaaaacctg gaagctatta     1800

ttcgtgcaaa agatggagct gccatgtatt cgcttatcaa tgctttatct accaacagag     1860

agatgtcaga gaaaattagg atcagaaaga cagtggatga atggattaaa actatttctg     1920

cagaaattca ggggcttttg aaagcaacca cagtaataca agatgaagat tatatgttac     1980

aagtctatgg aaagccagtt tatcagggcc atcgaagcac tcttaaaaaa ggaccatatc     2040

tcagatttaa ttctccatct cctaagtcca gaccacagag accaaaagta atagaacgag     2100

ttaaaggcac taaggtaaag tcaataagaa cacagactga cttctatgca acaaaaccta     2160

agaagatgga ttctaaaatg aaacattctg ttcctgtgtt acctcatggc gatcagcaat     2220

atttgttcag cccaagtaga gaaatgccta ctttttcagg tacattggaa ggtcatctga     2280

ttcctatggc aattctttta ggacaaaccc aaagtaatag tgataccatg ccacctgctg     2340

gagtgattgt cagcaagcca caccctgtaa ctgtgactac ttctattcct ccatcatctc     2400

gaaaagtaga aactggagta aagaaaccta acatagccat tgtagaaatg aagtcagaaa     2460

aaaaggatcc tcctcagctt actgtgcagg tattacccag tgtagatatt gacagcattt     2520

caaatagtag tgctgatgtc ctttcacctc tgtctagccc caaagaagca tctcttcctc     2580

ctgtgcaaac ttggataaag actccagaaa ttatgaaggt agatgaagaa gaggtgaagt     2640

ttccaggaac taactttgat gaaataatcg atgtcataca ggaagaagaa aaatgtgatg     2700

aaattccaga ctctgaacca attctggagt ttaacagaag tgttaaagct gattctacaa     2760

aatataatgg tcctccattt ccgccagttg cttctacttt tcagcccact gctgatattc     2820

tggataaagt aattgagaga aaagaaacac tggaaaatag cttaattcaa tgggtagagc     2880

aagaaataat gtcaagaatt atctctgggc tctttccagt ccagcaacag attgcaccta     2940

gtatcagtgt ttcagtcagt gagacaagtg aaccactgac ttctgacatt gtggaaggaa     3000

caagcagtgg cgccctccag ctttttgttg atgctggtgt tcctgtgaac tcaaatgtga     3060

ttaaacattt tgttaacgaa gctcttgctg agaccattgc tgtcatgctg ggtgacagag     3120

aagcaaagaa gcaaggtcct gttgctacag gtgtttctgg ggatgcttca acaaatgaaa     3180

catatttgcc ggcaagagtg tgcaccccac tgcctacccc acagcctacg cctccttgct     3240

caccttcatc acctgctaag gagtgtgttt tggtaaagac tccagattct tctccctgtg     3300

attcggatca tgatatggct tttcctgtga aagaaatatg tgctgaaaaa ggagatgata     3360

tgcctgccat catgcttgtt aatactccaa cagttacccc tactactaca cctcctccag     3420

cggcggcagt ttttacccca actttgtcag atatttccat tgataaattg aaggtatcaa     3480

gcccagagct tcccaagcca tggggtgatg gagacctgcc actggaagaa gagaacccta     3540

actcacctca agaagaactt catccaagag ctattgtaat gtctgtggct aaggatgaag     3600

aaccagagag tatggatttc cctgctcagc ctccacctcc agagccagtt ccctttatgc     3660

catttcctgc cggcaccaag gccccttccc cctcacagat gccaggttct gattcatcaa     3720

cactggagag cacattgagt gttactgtca ctgaaactga aactttagat aaacccatct     3780

ctgaaggaga gattttattt agctgtggtc aaaaattggc ccccaagatt ttagaagata     3840

taggactgta cctgacaaac cttaatgata gcttatccag cactctgcat gatgccgttg     3900

aaatggagga tgatcctcct agtgaagggc aagtgattag gatgtcccat aaaaaatttc     3960

atgcagatgc aattctttct tttgctaaac aaaaccagga gtcagcagtt tcccagcaag     4020

cagtctatca ttcagaggac ttggaaaaca gtgtgggtga acttagtgaa ggacaaagac     4080

cccagctaac agcggcagca gagaacatct taatgggaca ttctctctat atgcagccac     4140

ctgtcactaa tacacagtct ttggatcaac aatgtgatcc taaaccatta tctcggcaat     4200

ttgacacagt ttcaggtagt atttatgaag attcatgtgc tagtcatggt ccaatgagtt     4260

tgggagaatt ggagttggag ccaaattcta agctggttct tcccacaaca cttctgacag     4320

cacaagaaaa tgatgttaat ttaccagtag ccgctgaaga tttttcccag taccaactaa     4380

agcaaaatca ggatgttaag caagttgaac acaaaccatc acaaagttac ctacgtgtta     4440

gaaataaatc tgatattgca ccttcacagc aacaagtttc accaggtgat atggatcgga     4500

cacaaattga gcttaatccg tacctcacat gtgtattttc aggtgggaaa gcagtgccac     4560

tctccgcttc acagatgccc cctgccaaga tgtcagtgat gctgccgtca gtgaacctcg     4620

aggactgctc tcagtctctg agtctcagca caatgcagga ggacatggag tcttcggggg     4680

cagatacctt ctgaacggga agagacagcc agcacagtgt ttatgccact ggttttaaag     4740

tcattttacc ttggcttaaa accctctctc agactgtttg gtttttgagc atattctgaa     4800

aaaaaaa                                                               4807


<210> 378
<211> 6828
<212> DNA
<213> Homo sapiens

<400> 378
aatctcccaa ggcctaagga ggcaagaggc ctgcaaatcg cctcctgctc agcaaacggg       60

ttgctcagca ggcccggggt cctggtccac cccaggtccc tggtttgccc acctccgatg      120

gcggccttcg ctggcagggt gggcgcctct ggggagccag ctccgtcccg gcgcctttag      180

agccccatct cttccacgtc cctggccttc ctccccttcc aggcggctgt ccccgccggg      240

gtccagatgg tgtcggaggg ccggcggttc gacggcgggc ccggggttca gcctcccggc      300

ctccctccgt ccctgactct cctttcttcg gagagggcgc gggggccggg gccaaagcgc      360

cgctcttggg gttctcctgg actcggagtt gccccaggcg ggcgcagctc tgccccgcgg      420

ggtgccagcc tcgggcgggc aaggtccgtg agtcaccgcc tgtaaccgaa caccaggcct      480

ccctgccccc tcccccagct ccggccgcca ggctgcggcg acacctacaa gaaaatgaag      540

gggcgcccag gcccgcggcg gccccggccg tatcgcgagc aggtcccggc ggcccccggc      600

tcgcggcgct ctttcttccc cggccccggg gctcggccag ccgcaaccgc cgccccggcg      660

ccagcaggaa tccaggccga gcgaccggcc ccggagcccg aggcggcgga gggcccgcgg      720

tagctgcgac tggcgagccc gagagcgccc ggggaggggg cgcccggctt ggaatttccc      780

ggtcccttcc ggcccagcga ggacaaagca ctcctggccg ccgccgccgc cgccgccgtg      840

gcctacgccg cgccgcacaa agggcgagtc gcgacacgct cccatccccc tcccagctca      900

cggcggcccc ggccccgggt ggctgcaggg aggtggggga agccctggct gcaccgcccc      960

tcgctccccc tcccctgggg ccgcgcgagc gccgcccccg ccccgtctgc gcgtcctccc     1020

ggggaggggt tggggggcgc ggcgccccac ataacactcc ccctcctgcg ctgcgagcca     1080

ccctctcccc tccctcctgc aaacaccacc gcctcccctg ccaccgccgc cacctcgccc     1140

gacgctccac agctcgccgc ggccgggggg cggtgcgcgg accgtgcgcg ccgcgggcgc     1200

cagatgtgca gtccccgccg ccgccagtga ccgagccgca gtccgagcgg tatcgggccg     1260

cctccctgat gctgcggggg cgaccttgag cgtacagcgg cttccctcgg tggggacccc     1320

gacatcccag cgctgtgccc ggtcttgccc tctgtagccc ggctcgcccc gcgcttggac     1380

atggaagggg ccgccgcgcc tgtggcgggg gaccgccccg acttggggct gggggcgccg     1440

ggctctcccc gagaggcggt ggcgggggcg actgcagccc tggagcccag gaagccgcac     1500

ggggtgaagc ggcatcacca caagcacaac ttgaagcacc gctacgagct gcaggagacc     1560

ctgggcaaag gcacctacgg caaagtcaag cgggccaccg agaggttttc tggccgagtg     1620

gttgctataa aatccattcg taaggacaaa attaaggatg aacaagacat ggttcacatc     1680

agacgagaga ttgagatcat gtcatctctc aaccatcctc atatcatcag tatttatgaa     1740

gtgtttgaga acaaagataa gattgtgatc atcatggaat atgccagcaa aggggagctg     1800

tacgattaca tcagtgagcg gcgacgcctc agtgagaggg agacccggca cttcttccgg     1860

cagatcgtct ctgctgtgca ctattgtcac aagaacggtg tggtccaccg ggacttgaag     1920

ctggaaaata tactgctcga tgacaactgc aatattaaga ttgctgactt tgggctttcc     1980

aacctgtacc agaaggataa gttcttacaa acgttttgtg ggagtccact ctatgcatct     2040

cctgagattg tcaatgggag accttaccga gggccagagg tggacagctg ggccctgggt     2100

gtgttgcttt acactcttgt ttatggaaca atgcccttcg atggtttcga tcacaaaaac     2160

ctcattcggc aaatcagcag cggagagtac cgggagccaa cacagccctc agatgctcga     2220

ggactcatac ggtggatgct gatggtgaac cccgatcgcc gggccactat tgaggacatt     2280

gccaaccact ggtgggtgaa ctggggctat aagagcagcg tgtgtgactg tgatgccctc     2340

catgactctg agtccccact cctggctcgg atcattgact ggcaccaccg ttccacaggg     2400

ctgcaggctg acaccgaagc caaaatgaag ggcctggcca aacccacgac ctctgaggtc     2460

atgctagagc ggcagcggtc gctgaagaaa tccaagaaag agaatgactt tgctcagtct     2520

ggtcaggatg cagtgcctga aagcccatcc aagttgagtt ctaagaggcc caaggggatc     2580

ctgaagaagc gaagcaacag cgagcatcgc tctcacagca ctggcttcat tgaaggtgta     2640

gttggtcctg ccttaccctc tactttcaag atggagcagg acttgtgcag gactggcgtg     2700

ctcctcccaa gctcaccaga ggcagaggtg ccgggaaaac tcagccccaa gcagtcggcc     2760

acgatgccca agaaaggcat cttgaaaaag acccagcaga gagaatcagg ttactactct     2820

tccccagagc gcagtgagtc ttcggagctg ttggacagta atgatgtgat gggcagcagc     2880

atcccctccc ccagcccccc ggacccagcc agggtaacct cccacagcct ctcctgccgg     2940

aggaagggca tcttgaaaca cagcagcaaa tactcagcgg gcaccatgga cccagccctg     3000

gtcagccctg aaatgcccac actggaatcc ctgtcagagc ctggtgtccc tgccgagggc     3060

ctctcccgga gctacagccg cccttccagt gtcatcagcg atgacagcgt gctgtccagc     3120

gactcttttg acttgctgga tttgcaggag aatcgccctg cccgccagcg catccgcagc     3180

tgcgtctctg cagaaaactt cctccagatc caggactttg aggggctcca gaaccggccc     3240

cggccccagt acctgaagcg gtaccggaac cggctggcag acagcagctt ctccctcctc     3300

acagacatgg atgatgtgac tcaggtctac aagcaagcgc tggagatctg cagcaagctc     3360

aactagcatt ccagggcgcc caggggcggg cgggggtacg agggaggaag gggagcaaga     3420

cttgggctca caggctggtt acctctttgc tggctgtgac aacagactga aaaaggattg     3480

gcactgtctc acttggccaa gtttgcagcc ttgagccaac acctaaaagg gagaggtggg     3540

ctcttctgcc agttctgtca attgtcagtc agaatttggg ccctgtttgg catttgcttt     3600

atggcacctc ctagaggacc agctgtccag gggaggtggt attgaccggc actcagtggg     3660

tggagaggaa gcatatgtgg aaggagcatt tccttagaag tcatccagat gcttctggag     3720

gaggggcagg agacacttgg gctgtttgcc ttgggtgagc ccaaagaact tgcccctttt     3780

ctccttgtat tagcaagcta ggtctggctg cgtggagctg gcaagtagat ttcagcaact     3840

tgagcttgag ttgacgatca attaatagtg gctgccagtt gtgctggcgt aagtggccca     3900

catcatgggg aaggagtgct gtgattgact agtaatggct accacgggaa agggaagggg     3960

aagcagtagc actaatgcta tgtagttgtc atctttgatc tggctaggcc ctgggaatcg     4020

ggtttagtca tcctgtggga tctatgttaa ctctttcatg ccactggtga ggcatttgtt     4080

aatttgctac tcaactttga ggaaagacag ggccttggtc agagagagaa tgctctgaac     4140

tctgctaagg acatagagtc agcccatggt gatttagctc cttgctgttc acctcctctt     4200

tcctgatgtc tgccttgctc tacagcacaa cctcttgagg gtggacaggg agaaagatga     4260

tggtgtcaga ggtcaaaact attatatatg acagggcaca agatggtctg tgatctttgc     4320

acagatgaat ggaagttgat gcacaccaac aagaggcaac ttgtcacttt ctttctcaat     4380

attaactgga atgctgcctc ttgggttctc acctgcatgg atgctttgag ttggacgtga     4440

tactgtccat attctccaga ggattacctg gctgaaccat tggctctgtt caccagtgac     4500

agatggtttc cccatccact gagtgtagca tcctcagagg taggcaagtt tgcttctagg     4560

gagttagcat gtagatggga tattgggatg aggaaaggaa aatcaggtag atggtgcttt     4620

ttttccccca aatctaagta ttctatgtca tggttttaaa ctttgccatg aactcctggg     4680

ctttggggga agagaaagtt ccattcattt aaatgaataa ggtgttgaaa gagtgcaggg     4740

ggttgggagg aagcatgtaa gagagggaac atttccttag atgttaccca gatggttctg     4800

ggggagacag aaaagaggtg cggcaggact cttatcttaa aaagtaaaca aaacaaaaca     4860

aaacaaaaca aaaaactaga tatgtaattt ctaaacaccc agatcacaat gacaagatgc     4920

cactccaacc atgggacacc ttcatgatac taggtttgta cttcctggtc tctgggatga     4980

cttcagattc tgctggccaa ggcaaattga actcagttca agatggccac cactggtaga     5040

cgtgtagata gaaaagagga ctggtcttgg gaacatcttt ggaaaaacca acaaacaata     5100

gttctaggga gatgagaaaa aaattcacct tacagtgcta agaaagtgca ttagaatgga     5160

attgcccttt ccttaaggag acagtttggg ctctcccctt gccaccggct ctggtgtttt     5220

ggcttatgcg ttccttcagg ttgagctgag cagtgtgtta tgggaagctg ctcaatttcc     5280

tttcattcaa ttccacctcc ttcctgaact ctaatagagg ttaaaaggga aaaaaaaaat     5340

tctgtagata gcaaattgtg tgtgtggggg ggggtggggg tgtgggtgca tggaggacaa     5400

cctgcaactc tgagctccct acttcctgcc tcatttcatg cagtcttttc tgaacagcct     5460

atgctgctgc cctgctggcc ccttgtgcac ggcagctggc cgtgtccgta gctgtcagta     5520

tgacttagat ctagctccta cctactggtt gatgtgtttt ttccttttgc caagtgattg     5580

agtctgttta gtagtttcca tcattctagt ctttaagtaa aaatgacact attgaggaaa     5640

gtcagtctac tcccttcttc ctccccccaa acacgtgttc tcttttgtca ggaaactcag     5700

ccagtggact gtggcagaga aagtcctcca ctcagaggca gagactgagt taagtcatag     5760

gtggccttag gcatctgcat tgtttgcagg ggttaagttt tccttccagt gagggctgga     5820

gggatgaatt agctggtacc tgaagccccg cttagctctg acactctgcc aacatcctct     5880

gattctaggt gtggtgttga ctgtcctttc aaggaaaaac ttgcaataga gggaaaagcc     5940

attaaagcag ctccctgctt catcattaag tcctgtcatc cctaccagcc aatcccagtc     6000

aaagaagtta tgctttattc acttctgtgg aattacaagt gagagacact tttaggacct     6060

gatggacaaa gcaggagatt cactgtcagc tttcctggtc ctctccttac ttctgtgggc     6120

cttgcaccgt cttagtttac acatctgcca aaggggtaga attacacttc tttttacagg     6180

taaatgtcaa ggcacaatca gttttcagga agtgcttcaa gaccccaggt gaaatgaaaa     6240

tgctaagtac cctctgaatg gccatgcctg ttaccaggtg ctgcttcttc agatgatggg     6300

gagcactttt cagggtgaaa ttcaggcgag ttttgcccag gcctgctgtc ttgagtacaa     6360

atgtgaatga tcgactgact gcttgttgcc aaactggaaa tgttctgtag ggatttactg     6420

gcatggtatc attcctagaa gaaaaaaaga gagaaacttg actgcacatt aaaaaaaaaa     6480

aaaaatccac attgtgactt ttatttaatt tctatttttt ttggtaataa aaagttgact     6540

tttttatttg aatttgtctt ttttatttat tggtctgaaa ggcatttcaa aggtattata     6600

ataatatatt ggtgtaattt aattggtgca acatgcttta tggctcctgt caaaattggt     6660

tttcactcat ttgattggtt tgagcccaga acagcctaca ggggaaaaac aagctggata     6720

accacccaaa gtgtttgtat tttcgttgga aactgatttt tgtttcattt tggtttttgt     6780

ttctgttttt atttttaaat taaataaatt gcaatgaact gaaccaga                  6828


<210> 379
<211> 5245
<212> DNA
<213> Homo sapiens

<400> 379
acgcgagctc gtggctcggg cgtatggggg ctccaacggg agcggctgcg ccgcccggcc       60

gggtcaacgt cgtgcgcatg cgccgacccg gcgccatttt ggtggccggg cgcggaggtg      120

attccacact gaggcgagcg cggcggccgg ggtggtagtg gcagtgttcg tgtgctcagg      180

tctgaatcgc cgagggagga ggcggtggag gaagaggtgg cggcggtggc ggtggtcgta      240

gcggtggcgg aggaggcggg tacgaatcag ctgcgggcgg agacatggcc aacatcgcgg      300

tgcagcgaat caagcgggag ttcaaggagg tgctgaagag cgaggagacg agcaaaaatc      360

aaattaaagt agatcttgta gatgagaatt ttacagaatt aagaggagaa atagcaggac      420

ctccagacac accatatgaa ggaggaagat accaactaga gataaaaata ccagaaacat      480

acccatttaa tccccctaag gtccggttta tcactaaaat atggcatcct aatattagtt      540

ccgtcacagg ggctatttgt ttggatatcc tgaaagatca atgggcagct gcaatgactc      600

tccgcacggt attattgtca ttgcaagcac tattggcagc tgcagagcca gatgatccac      660

aggatgctgt agtagcaaat cagtacaaac aaaatcccga aatgttcaaa cagacagctc      720

gactttgggc acatgtgtat gctggagcac cagtttctag tccagaatac accaaaaaaa      780

tagaaaacct atgtgctatg ggctttgata ggaatgcagt aatagtggcc ttgtcttcaa      840

aatcatggga tgtagagact gcaacagaat tgcttctgag taactgaggc atagagagct      900

gctgatatag tcaagcttgc ctcttcttga ggagcaccaa catctgttat ttttaggatt      960

ctgcatagat ttcttttaaa ctggcattct tgcctaatga tgttatctag gcaccattgg     1020

agactgaaaa aaaaaaatcc ctgctctgta aataaagcta attaaacgtc tgtgtaaatt     1080

taaaaagggg aaatacttta attttttttc ttaatagtgt aaaaattccc tgagctaagc     1140

taaaaccatg gaagaaacat gctactttag tgtttagcag tgtaccaaga ctagcaagag     1200

tttgcttcag gattttgttg aataattaag ataatatttt gagtgtgtca gggccattca     1260

aattgttggt gttgcatcac agctacctta actgttttta acatggatcc tctgtgcctg     1320

tgaatttact tgcatgcttg tacttgactt cttaggatgg gtagctgaaa agaccaccat     1380

tttaagcatt tgagaattct taaatatgaa atttattcag aattgaagat ggtgacctat     1440

tcagagcctt tttgtccttg tcaacagact gggacagtgt ctgattcccc cttcaccccc     1500

cccacccccg ccttgccaca cacagctaat attctaatgg taaatttctc tgtatcaggt     1560

ggggaaatgt gctgaaggac agtatgtatc ccttgcttca tttttaggtc gtaggtttgg     1620

aatgtcttgt cccagttctt caaacactct taaatttttc ttaagtaatg taaaaatgga     1680

actgccaatt ttatttctct tgcaaaaata gtaaatactt gatgttacat tattcccagg     1740

tttaatgaaa gaacccaact tagtttttca gtgaatttga cacctatttt ttagtgatga     1800

aatttttctt tgagaactgg caaggatgca gtcagctgtt tgcagttttt agcctgattt     1860

tggggtctat agagattgct ttattggata cttcaagtca ttcttgcttg cacttcccct     1920

attgacacat gaaagctgtg ttggtgtttt attgtacata cttcagatgc acataggaat     1980

agaagtgtgt tataaatcta gctttcttta tgatgtttct gataatacga gaattgaaaa     2040

ctttaccttc tcttgtacat agtcagacta tttgtattaa atttacattt cattctaagt     2100

tcaaaagttt gaaaattatt agttttgcaa gatcacacac taatgtaacc attttatgaa     2160

ggttgaagtg gatttatgca ggcagttcta tatatagaaa tacaattctt tttaaatttt     2220

taggaccaat acaaaataac aaaaatgtaa tggaatcaga ctgaattaaa gtaaggctgt     2280

atattgaaag tcatattata aaaggtttgc tttctttaag tgttatttat cttaaattat     2340

aatcgttaaa tgtttggaag ataatttttg aatcataacg tcagcataac ttcatttgac     2400

ttctcaataa tcttgatact agaagcaata aaagaaccat tattaaatat attgtaatgt     2460

taaagatgtg aaggttcttc caaaaatttg taaggctttc ctaattaaca gtaaactctt     2520

atagctgata ttattacata ctaaacacaa gttgctgttt tttccccata tgtttgctta     2580

cgcatgtctt tatacaatca cctcttttta ttgctgtagt ttattttcta aagatgccaa     2640

aggaaacaag atttttcttt atttatttta aatacctgaa acctcgtact ttatattttg     2700

aagtaaggtg ggattgtgtg aaaatgtgga tggtttttct ccagtgttgg ttagaactac     2760

tttttttaag tggagggcaa cttggtagta ttagtagaat ttgggtttaa aaatatcaga     2820

cacatctacc cagtttattt tttgcctgta ttatcagggt atatttaatt gtcctgtggt     2880

taaacaaagg tgagagagct cagaggtttc taaaggtcaa gcattttaca tatatacata     2940

catacatgct cttggaggca gctatatcct gctttgattt ttatgcacat gagccctata     3000

gggttatata ctcatctaac tacacttcag catccccagt gcccaagaaa ttggaaagta     3060

caatatttgg tttgagacat tcttcataaa agattcttta ttataaaaat ttacctcatt     3120

tacatttaat gtgatgatct tttttttcct ttctggtata tttcccactg tactgtttgg     3180

tttttgttat tctcttgtct gtgggtagat ttagttaccc aaacatagaa actaaagcaa     3240

ttgctttttt cctctggtct taaatatgtt tggacaaaaa gacactaaaa ggtcaggcct     3300

aggggaaaag taccctggtg gaaattattt ttgtaattct taatattttt gagttggctc     3360

cgtttgtcag ttttaaaagc ctcaaaaatt atgttaaaaa aaaaatccag tgaaatccca     3420

tttagggcag gccgatttgt tagaagtcac tgatgctcca gtaggctttt gttataatca     3480

ggcctgtttc ctgagtatgt gcctctttta aaagaagaaa taattagctg tatagtattt     3540

cagtactgat gaatgaatga atgaatgaat ggcagttagt ggacccaaat aagtattcag     3600

tggtatataa atatttgagg aactaggtac tgaattaggt gctctgagtt ggcaccccga     3660

aatgtttgga atcacgacta tgatttactt aaacacgtaa cacattcaag gatatataaa     3720

tggagtctaa gtattttgct tttgaagaga ataatctatg aaatggaaga cttgattttt     3780

tttttcattt tttagaagta atacacattt atgattgttg gcacataaaa ctatgcaaaa     3840

taattctttt taagtatctg taagaaagaa ttggcagttt aaacggattt tgcttattta     3900

tgcactacag aatgcagcat actgtattac tgttgaggct gcttaataag tttaccaatg     3960

tgaaaagcag atcttgggta taagtgtatg cctgatttga gcttttaaaa ctgtgcagta     4020

ggtgtatggt aatgttttac aatcctatgt agcaaaatag gaaattatga atttttgttg     4080

ttattgtttt aaagatttaa gatggattgg ggtagggaac agctggagcc aggtatacct     4140

tctagtatgt agagggaaac aatgtttaga taggaaaaag gaagccgtct gtttacagtt     4200

aactttattt catggacttc tacaaaatgt tgtattaatc actttttcta gttcaaggaa     4260

tttcaattcc agggtacaaa ccattgattt aaaaattacg tttccattct ttttagtatc     4320

agtttaaagt aaatgcttac catcagccag ttgctgtcac tgggaagaag gcaacttgaa     4380

gtatttactg ataaaatagc ctttattccc aagtgtgact tttcttcagt gtctacatat     4440

tatgtcacac gttctatttg cactgctgca atatagatca aagatcttgt ggcatagggg     4500

taggggagtg ttagtatctc ccttgtccca tttgttctgt tactgcttca ttggactgat     4560

acaccctcat gaacttgcaa tcacctaaat ggaagtcttg aatgtgtcac cttttgcttg     4620

gttatttcaa ccatgctgct atatataatc aggtgtggca cagtttgtca gtttgattat     4680

aggtgtgagt ggatagaaat cattacactg tgctgttaac gatccttgtc tgcttgctgt     4740

tacctacttt ttacaggcat cataataaaa gctagactat ttctttgggg ggaaagagac     4800

ttatttaatg taatttaaaa aacttttcca atagaaaatg aaatattatt gaaaataata     4860

tctatttttt agctttcagc aattgatggt gctttgttgt ggtgtctgct ggaagtctac     4920

tgccattata gggaaccttg cttgttagct tctctagatc tctattctaa acaatctgtt     4980

agtgatgata aattctgtag gagggtctat tctgagccgt taacttcctg taaggggaaa     5040

atgggtgggt taccagaaat accattgaag cagggtgggc tgtggggtgg aaggttgggg     5100

tatttgtctt gagaattaaa aactacgaaa cacttttgta cacaactgat tttttaaaaa     5160

ataaacacat ttttaaagat gttgaatttt tcccccctta ttgggaattc ttaaaaataa     5220

atgcatgcat gttttcccct gaaaa                                           5245


<210> 380
<211> 9744
<212> DNA
<213> Homo sapiens

<400> 380
ttccccggcc ggacggagag cggcagtgtc tccccgccgg gcgcgctcgc cgtgtctccc       60

ccgcggccgc agctgcttgc tagccttgcg cggcgcggga gagcgcagtg gcgccggcgg      120

gaaagggctg cggacctgcg gcgccgcgtt gtgcgttcga cgacgcggca ccggcttcga      180

cgccctctgc ccgctccaga agcagtaaga agacatgttg gataacaaga agaggtgtag      240

agtttgcata tatcaactgt ggccttaatg agcatgttga cagcatcgat gctagacaga      300

cagtcttttt actgctggat tgtgcaagat atttaaccct attttgtttg aattatgact      360

taaatgtcaa acatcttaac taagaaaagg gaaacatttt agttttggaa gtcagaatgc      420

caaggagaag gaaaaatctt gggggaaatc cttttcggaa gactgcaaac cctaaggaag      480

ttgtcgtatc cagtgttgct agtcgtgagg agccaaccac tactctacct tccatgggtg      540

agacaaaagt tgatcaggaa gaactcttca ccagtatctc agagatattt tctgatctgg      600

atcctgatgt agtgtatttg atgctttctg aatgtgattt caaagttgaa aatgctatgg      660

attgtctatt agaattatct gccactgata ccaagataga agaatcatct tcacaaagtt      720

tcgttgcttc tgagaaccaa gtaggtgcag cagaaagtaa aataatggaa aaacgtcctg      780

aagaagagag tgaagattca aaaatggatt catttttgga catgcagcta actgaagacc      840

tggattcctt aatacagaat gcttttgaga aattgaactc ttctcctgat gaccaagtat      900

actcattttt gccttcacaa gatgttaata gttttaatga ctcaagtgag tttataaatc      960

ctgattcaag taatatgact cccatttttt ctacacaaaa tatgaatttg aacggtgaaa     1020

atttagagaa ttctggttct actttaagtt taaacccatt accttcacat tcagttttga     1080

acgagtccaa gtgttttata aaggataaca cattggcttt ggaaagtaac tacccggaag     1140

attctcttct cagtagttct ttaaatgtag caagtgactc catcgcaggt tgtagcagtc     1200

tcaatcaaaa acagaaagaa cttttagaat ctgagtgcgt tgaggctcaa ttctctgaag     1260

ctcctgtaga tttggatgcc agtgaacctc aggcttgttt aaaccttcca gggcttgatt     1320

taccaggtac aggtggggat cagaaatcta ctcgggtctc tgatgtgttt ctaccttccg     1380

aagggttcaa cttcaagcca cacaaacatc ctgaactgcc aactaagggg aaggatgtga     1440

gttactgccc ggtacttgct cctctcccat tgctgttgcc tcctccgcca cctccaccga     1500

tgtggaatcc aatgattcct gcttttgacc tcttccaagg aaaccatggc tttgtagctc     1560

ctgttgtaac cacagctgca cactggagat ctgtcaacta cacatttcca ccctcagtta     1620

tttctcacac ttccccaaca aaagtatgga gaaataaaga tggaacaagt gcttatcaag     1680

tacaagaaac cccagtttct caggttgtaa gaaagaagac atcttacgtt ggactagttc     1740

ttgttcttct cagaggtctt ccgggatctg gaaaatcttt tttggcaagg actttgcaag     1800

aggataatcc aagtggagtc attcttagta ctgatgatta tttttatata aatggacagt     1860

accagtttga tgtaaagtac ttaggagaag cacatgaatg gaaccagaat cgtgcaaaag     1920

aagcatttga gaagaagata tctcctataa ttatagataa tacaaaccta caggcatggg     1980

aaatgaaacc atatgttgct ttgtctcaga aacacaaata taaagtcctt tttcgggaac     2040

cagacacatg gtggaagttt aaaccaaagg aacttgcaag gcgtaacatt catggggtaa     2100

gcaaagaaaa aataacaaga atgttggaac attatcaacg ttttgtttca gtgccaataa     2160

ttatgagttc ttcggttcca gagaaaattg aacgtattga gttgtgtgca tattcttgtg     2220

aggatagaag cactagccca agagacgatg aagatattat ctctgaaaaa gaagaaaata     2280

ttttatcttt atctttgaag catctagagt tcactgaaga gaagaatctt gatgtaacca     2340

aagaaacaat gttacctgag aatgttgcat atctctctaa tgcagattta aacaaaagaa     2400

gaaaagaaat aagtgatatg aatcctagca ttcaaagtgc tttaattctg gaaactccac     2460

acatgtattt ttctgactct gaaagcaaac tacaggcaac agacaaaagt gaaaacgagc     2520

aaatagaaat ggtggctgta aaagggtata gtaaaactga cacagatagt tctatggaga     2580

gagtatcacc tagtacttgc tgtagtgaaa ataatcaaga agactgtgat cttgcaaata     2640

gtggaccact tcaaaatgaa aaatcctcac ctggtgaaat agtggaagaa agagcaacag     2700

taacgaaaaa agcctttggg aaacaaaaaa gcaaatcgac tttggaaaag ttcccaagac     2760

atgagctatc aaattttgtt ggtgactggc cagttgataa gactattggt cagaggacaa     2820

aaaggaacag aaaaactgaa aaaacttcat ccgtacaaag cgacaaaaag tataattacc     2880

ctcagtcaca caaattagtt aacagtgtat ctgtgaatac agattgtgtc cagcaacgag     2940

gatctccaca tgaaagtgta gaggatggca gaaagtcaca gtgtgatgat gcttcagagc     3000

cactcaatag ctataaatat gatgcttata aaaatattga caaaaactca ttcaacatta     3060

tgggtgactg gccttcatct gattctttag ctcagaggga acacagatca agaatgccaa     3120

agactggttt aagtgagccc aacctagaaa ttggaacaaa tgacaaaatg aatgaaatat     3180

ccttatctac agcacatgag gcctgttggg gcacaagctc tcaaaaacta aagacattgg     3240

gtagctccaa tctaggaagt tctgaaatgc tgctcagtga aatgacctgt gagagtcaga     3300

cttgtctaag taaaaagagt catgggcaac acacatcgtt gcctcttact tttaccaata     3360

gtgcaccaac tgtttctgga gtagtagaac cacaaacgtt agctgaatgt caagagcaaa     3420

tgcctaagag agaccctgga aaagaagtag gcatgtgcac ccagactgaa ccacaggatt     3480

ttgctctttt atggaaaata gaaaagaata aaattagcat ttcagattct atcaaagtat     3540

taacaggaag attagatgga tttaagccga aagttttcaa tattaacaca aaatcagacg     3600

ttcaagaagc aattccatat agagtaatgt atgataaaag cacgtttgtt gaagaaagtg     3660

agcttaccag tgcagatgaa tctgaaaatc ttaacattct ttgtaaactg tttggatcct     3720

tttcattaga agccctgaaa gacttatatg agaggtgcaa taaagatatt atttgggcca     3780

caagcctttt gttggattct gaaactaagt tatgtgagga tacagagttt gagaatttcc     3840

aaaaatcgtg tgatggatca caaattgggc ctttttctct ggggttgaat ttgaaagaaa     3900

ttattagcca aagaggaact ttagagaatt ctaattctcc tgtgccagag tttagccatg     3960

ggattggtat tagtaacgct gactcacagt ctacttgtga tgcagaaaga ggaaactcag     4020

agcaggcgga aatgagagct gtcactcctg aaaaccatga atcgatgaca agtatatttc     4080

ccagtgctgc tgtgggtcta aagaataata atgacatact tcctaacagc caggaagaac     4140

ttttatatag cagtaagcag tcctttccag gtattctaaa agctactact cctaaagata     4200

tgagtgaaac agaaaaaaac ctagtagtca cagagactgg agacaacata cattctcctt     4260

cacatttctc tgatattttt aactttgtat ctagtacttc aaatcttgaa ttaaatgaag     4320

aaatttattt tactgattct cttgaaataa agagaaatga aaattttcca aaggattatg     4380

tgaaattttc agatgaagaa gaatttatga atgaagatga gaaggaaatg aaggaaattc     4440

taatggcagg aagtagttta tcagctggag ttagtgggga agataaaacc gagatattga     4500

atcccactcc agcgatggcc aaatctctga ccatagactg tctggaattg gcattacccc     4560

ctgaactggc ttttcaactt aatgaattat ttggtcctgt tggtattgat tcagggtctc     4620

taacagttga agattgtgtg gttcatatag atctgaatct ggcgaaagtg attcatgaga     4680

aatggaaaga atctgtaatg gagcgacaaa gacaagaaga ggtgtcttgt ggcaagttta     4740

tgcaagatcc ttccttggtt ggacatactg ggcttgataa tcctgaacaa aaatcatctc     4800

agagaacagg caaaaaatta ctgaagactt taacagcatc tgaaatgcta cctttattgg     4860

atcattggaa tactcaaact aaaaaagtat cactcagaga aataatgtca gaagaaattg     4920

ccttacagga aaaacataat ttgaaaaggg agacccttat gtttgaaaaa gattgtgcca     4980

ctaaactaaa ggagaagcag ctctttaaga tatttccagc cattaaccaa aattttctgg     5040

tggacatttt caaggaccac aactattcat tagaacacac agtgcaattt cttaactgtg     5100

ttcttgaagg ggaccctgta aaaacagttg tagcccaaga gtttgttcac caaaatgaga     5160

atgtcacatc tcatactggc cagaagtcta aagagaaaaa gccaaagaaa ttaaaagaga     5220

ctgaagaaac accaagtgaa ctgtctttcc aggactttga gtacccagac tatgatgact     5280

acagagcaga ggctttcctt caccaacaga agaggatgga gtgctacagc aaggccaaag     5340

aagcttatcg gatagggaaa aaaaatgtcg ccacctttta tgcccagcag ggtactcttc     5400

atgagcagaa gatgaaagaa gccaatcacc ttgctgccat agagatcttt gagaaagtca     5460

atgcttcgct gctgccacag aatgttttag acctccatgg gctgcatgtg gatgaagctc     5520

tagaacattt gatgagagtt ttagagaaga agactgaaga atttaagcag aacggtggga     5580

agccctattt gtctgtgatt acggggagag gaaaccacag ccagggagga gttgctcgca     5640

tcaaaccagc tgtcattaag tacctcataa gccatagctt caggttctct gaaattaaac     5700

cagggtgctt gaaagtcatg ctaaagtaaa ataaacatcc ttgaattaga agtatgaagg     5760

tttgtaggtt aaaattactt ttatttgcag taattcagtc aattctaccc taaagatgtg     5820

ttttattata aataatattc aattatgaaa caaaaaaatt atgatgtttt tcaaaatgca     5880

agtgaggttt gattttttac tgaatcaaat gcaaatgtta cctgttaaag atattacaga     5940

gaaattttat tgattacaaa atatgtaaga aaattatcag ctacagtttt aaagtttaaa     6000

atgctctgat tgtttctcag aaaaggttac ctttgtatta attgttgtat gacatttagt     6060

aatgtcctaa aagtcttttg tgagaggtat ttaaagtgct ttgagacctg attcatgccc     6120

cccaaagggt ggtattaaaa gaggaaaaag gacatagtag tggtagtaaa gaaaaaaagg     6180

agatctaaca aaaacacttg aatatttttt attttcaaaa ctaaacacat aaaatgcttt     6240

tattttgcca tatcctacag gaaggaagac atgcttttgc cctttcttct gctttgtata     6300

tgaccttgat cttttacctt ttgttctgtt cttctgtgtg cattttatgg aaagaaagtt     6360

gggtctgaga ttatattgta attttatact ttctatagac agaaaggttt tcagagaaaa     6420

agaaatggtt aaatatcttc cagatgttgc tgccttatcg aaatgcttct agaactgtct     6480

gtataagtcg tatttcagac agtactaaat acttatattt tatttttgag gcatgtaatt     6540

ttaaaactgc agtaggttaa aattctatta aacaaatata gaaaatattt tgtttataat     6600

tggcctggtg tggtggccca cgcctgtaat cccagcactt tgggaggccg aggtaggtgg     6660

atcgcctgag gtcagaagtt caagaccagc ctggccaaca tggtgaatcc ccgtctctat     6720

taaaaataca aaaattagct gggtgtggtg gcgtgtgcct gtaatcccag ctacttggga     6780

ggctgaggca ggagaaccgc ttaaacctgg gaggtggagg ttgcagtgac ccgagatcga     6840

gatcacacca ctgcactcag cctgggtgac agagcaagac tccgtctcca aaaaaaaaaa     6900

agaaaaaaaa gagaaaatat tttggttata atcataagaa gaatccttac aatttaaaat     6960

attttcactt ttattttgaa aaagagccaa ctttctcaaa ggaagctgtc attaacttct     7020

gttgtttggt tagctaataa attctgttag tatgcaagtt aaacctgtgt aaaggaggtt     7080

ataatgtggt aaggtataat tttccaatat gagacaatgg cttaaatttg cctttggaga     7140

tggagaatat tttcaacata cataatttta acaaatagtt ttgttgcttt ttgttaagct     7200

taaaaaaaaa tttggatcag aaattatagg attgagctgg taccaaaaga atcctaaagt     7260

acagaatggt tttccaaaag agcagacatt tcaatgaaaa taaaacccca aaacattttt     7320

tttatatatc atgattgcat gcttttaaaa taaggaggct tatcattgaa ttttagttcc     7380

ataaaaatga aaatacatgt ttattattta gaaatggtta gtgactggta ttgaagtatt     7440

attcacactt atgtttgtaa taatttattt aaagaatgcc aacagtttag cacacttttg     7500

taatctctag aacagttcta tacattaaaa ataaacatta aaaataaagc agttccttta     7560

aacaacttac tatgaaacta taattgttaa tgaaataaga tattcctatg tatacattag     7620

tatgatttaa gggtatgaaa aacagtgcta aaatgtggag ttaattggaa tgtgtgcagc     7680

tgcatactca ctttctgtgt ttttatattt ccttacctag ttttaaaaat catcactttt     7740

cggcacttca gctagactta tttcaatatt ataattatga ttaatgaagg agcagtcaga     7800

agtagaggtg tggtattccg tgggcagaag tcaaatgaaa aaagctatat tgtttacttg     7860

tttactatat caatgttaat attatgcctt attttgataa atcaaatagt atatcttaat     7920

cattgttgat aaatatacag gcaaagtttg agcatcatat gtatttttat gaagctgctt     7980

aattccaaat tgcctcccac cccactatct agcatagttt aagcaacaca taattttgaa     8040

agaaaagttt gtaatccctc ctttcttttt tttgcccatt tctaaatcct gtatgcccgc     8100

agtaaagata gtttggggat tttaaaagtt ttctctatta cccatttcta aatcctgtat     8160

gtcaaagata gtttggagat tataaaaatt ttcatgtatt ggtgtaggtt gagtatccct     8220

aatgagaaaa ttcaaaatct gaaatgcttc aaaatctgaa atttttcgag cacagacatg     8280

atgctcaaag gaaatactca cagagcattt tacatttgta ggttagcgat actcaacaag     8340

taaatataat gcacatgttc taaaatatcc ccccaaaccc cagcaatcca aaacacttct     8400

ggtcctaagc attttgagta ggggatactc actcaacctg tatatttgtg ctaatacatg     8460

actcattaga atgattcttt gtaaacttaa tattttaaaa gtacagcact tctgtagtat     8520

ggaaggtttc agtaataatt atattcattc agtagtctct taccattatc tcccagatgg     8580

aaaaagagga ctaatgtgga aaccccagag ggtgtccagt tggaccaggg agatattaga     8640

cacttaacag tattttcagt ctgtccatct ctttattcca atgtgagaaa tggaagtgtt     8700

ttttttttta cgtttattgg ctcttcatat ttctctacat tatttttaat gtgcagtttc     8760

ttcaattggt tagtatttcc atactatttg caactttatg gcctttaaat ataggacata     8820

ttatatagca gaaattttga ctttaaatcc tcttgagtag tatattttga gaagaaaagc     8880

tatactgctc ttctggatgg tttccatcct ttatttaggt cttttctttt tgaattcaag     8940

tgttttgtat gcttagaaag tagacatgta taatattgag atcggttatt tctgagctgg     9000

aaattggaaa ctttggaaac tcaggaaatt gctctgacaa tgttttaact gctctcaatt     9060

taagaaaatg acgaaatgta taaaaaagac aaaaataacg tgtgctgttt tttccaagtg     9120

ctttttctaa gtgcttttcc attgtgcaat gaggtgaagt ttggtaattt ttcggtgtag     9180

tagttaaata ttgctcaatt tttatttaca tgtaaagaaa acagatttaa atgtttatgt     9240

ggccaaaagg tgtcatttaa aaggtaaaat aagtttatgt agaatgtatg ttcatggtgc     9300

ttatttttaa aatgtaattc aagtttacag tattacttaa tgcttcttta cagaatttaa     9360

tagagaaaca aggctagaac acatctacat cctgaagagc cgtttataac ttcatattat     9420

atgatgacaa agttcattat tttccttaaa gttgagcaat tgacttttat ggtccaatga     9480

tgaacttatt attaataaat gattgagtta actgtgaggc ttctcattaa aatacaatat     9540

tgcagctatc agttggagaa tatattataa aattttcaga cagtatatca gaaaaatgtt     9600

tttatttgta ctgtatagaa aatgtaattt tgctgttaac tctgtacttt ttaaattgaa     9660

aatgttttat aaatttgctt ttaaattttc ttatgaagcc atttgcaaat tacatactta     9720

atttaataaa atactttagc caca                                            9744


<210> 381
<211> 1839
<212> DNA
<213> Homo sapiens

<400> 381
ctaatgaact cctgggtcac gtggtgcgca cgcgccaaag gcacacgata aaggaaaacg       60

cgggcttatc gtggccttta aaatccggct tggtgagctt gggtcgcctc tgaaggagaa      120

ccattttcca tctctttcat agttttttcc cccagtcagc gtggtagcgg tattctccgc      180

ggcagtgaca gtaattgttt ttgcctcttt agccaagact tccgccctcg atcaagatgg      240

tggttggacg gccttcctaa cctttacggg gcctggcggt gctgacgcct gagctggtag      300

gggtggagca ggtaggaaac agcaaatgca gaagctgctg cgcggaagtc ggccatggac      360

tggaaagaag ttcttcgtcg gcgcctagcg acgcccaaca cctgtccaaa caaaaaaaaa      420

agtgaacaag aattaaaaga tgaagaaatg gatttattta caaaatatta ctccgaatgg      480

aaaggaggta gaaaaaacac aaatgaattc tataagacca ttccccggtt ttattatagg      540

ctgcctgctg aagatgaagt cttactacag aaattaagag aggaatcaag agctgtcttt      600

ctacaaagaa aaagcagaga actgttagat aatgaagaat tacagaactt atggtttttg      660

ctggacaaac accagacacc acctatgatt ggagaggaag cgatgatcaa ttacgaaaac      720

tttttgaagg ttggtgaaaa ggctggagca aagtgcaagc aatttttcac agcaaaagtc      780

tttgctaaac tccttcatac agattcatat ggaagaattt ccatcatgca gttctttaat      840

tatgtcatga gaaaagtttg gcttcatcaa acaagaatag gactcagttt atatgatgtc      900

gctgggcagg ggtaccttcg ggaatctgat ttagaaaact acatattgga acttatccct      960

acgttgccac aattagatgg tctggaaaaa tctttctact ccttttatgt ttgtacagca     1020

gttaggaagt tcttcttctt tttagatcct ttaagaacag gaaagataaa aattcaagat     1080

attttagcat gcagcttcct agatgattta ttggagctaa gggatgagga actgtccaag     1140

gagagtcaag aaacaaattg gttttctgct ccttctgccc taagagttta tggccagtac     1200

ttgaatcttg ataaagatca caatggcatg ctcagtaaag aagaactctc acgctatgga     1260

acagctacca tgaccaatgt cttcttagac cgtgttttcc aggagtgtct cacttatgat     1320

ggagaaatgg actataagac ctacttggac tttgtccttg cattagaaaa cagaaaggaa     1380

cctgcagctc tacaatatat tttcaaactg cttgatattg agaacaaagg atacctgaat     1440

gtcttttcac ttaattattt ctttagggcc atacaggaac taatgaaaat ccatggacaa     1500

gatcctgttt catttcaaga tgtcaaggat gaaatctttg acatggtaaa accaaaggat     1560

cctttgaaaa tctctcttca ggatttaatc aacagtaatc aaggagacac agtaaccacc     1620

attctaatcg atttgaatgg cttctggact tacgagaaca gagaggctct tgttgcaaat     1680

gacagtgaaa actctgcaga ccttgatgat acatgatctc tgaaagacta gactgtctta     1740

tattatgaga tacttgaatg ctgcatgtaa agcctttaaa gcaaaatcct cagaaatggt     1800

ctaaataaaa cacttgatat gcctagagaa cacagcaaa                            1839


<210> 382
<211> 6003
<212> DNA
<213> Homo sapiens

<400> 382
gacctcccac aactggagca gccgggaaca gctctgacca cagtggttcc ggggagaagc       60

ctttccagga cccatgtgta ggcacaactg ttttccctga tcaggatact tgcggcactc      120

aacagaggaa agaaattcct aagggaacac tgctcagaaa gtactgcagc atgtcttcaa      180

atgcctgagg atcaagttgg aaaactagaa gcaacagaaa acacaataag cgcaatggcg      240

gcggccgcgg cggagcagca acagttctac ctgctcctgg gaaacctgct cagccccgac      300

aatgtggtcc ggaaacaggc agaggaaacc tatgagaata tcccaggcca gtcaaagatc      360

acattcctct tacaagccat cagaaataca acagctgctg aagaggctag acaaatggcc      420

gccgttctcc taagacgtct cttgtcctct gcatttgatg aagtctatcc agcacttccc      480

tctgatgttc agactgccat caagagtgag ctactcatga ttattcagat ggaaacacaa      540

tctagcatga ggaaaaaagt ttgtgatatt gcggcagaac tggccaggaa tttaatagat      600

gaggatggca ataaccagtg gcccgaaggt ttgaagttcc tttttgattc agtcagctct      660

caaaatgtgg gactgcggga agctgccctt cacattttct ggaactttcc tggaattttt      720

gggaaccagc aacaacacta tttagatgtc atcaaacgaa tgttagttca gtgtatgcaa      780

gatcaggaac acccgtcgat caggacgtta tctgctagag ctacagctgc atttatactt      840

gcaaatgagc ataatgttgc tctgttcaaa cattttgcag acttgctacc gggattccta      900

caggcggtaa atgactcgtg ctaccagaat gatgattctg tcctaaaatc cctcgttgag      960

attgcagata ctgttccaaa gtatttgcgt cctcacttgg aagcaactct acagctaagt     1020

ctaaagttgt gtggagacac tagcctcaac aatatgcaac gccagcttgc ccttgaagtg     1080

atcgtcaccc tctctgagac tgcagctgct atgttaagaa aacataccaa tattgttgca     1140

cagactattc ctcagatgtt agcaatgatg gttgatttgg aagaagatga ggactgggca     1200

aatgcagatg aactagaaga tgatgatttt gacagcaatg cagttgcagg cgagagtgct     1260

ctagatcgaa tggcttgcgg acttggtgga aagctcgttc tgccgatgat caaggaacac     1320

attatgcaaa tgcttcaaaa tcctgactgg aaataccggc atgcaggatt gatggcctta     1380

tctgccattg gtgaagggtg ccaccagcaa atggaaggaa ttctaaatga gatcgtaaat     1440

tttgttttac tttttctcca ggatcctcat ccaagagtaa ggtatgcagc ctgtaatgcc     1500

gtgggacaga tggctacaga ttttgcacct ggtttccaaa agaaatttca tgagaaggtg     1560

attgcagctc tgctgcagac catggaagac caaggcaatc aacgtgtgca ggcccatgca     1620

gctgctgccc tcattaactt tactgaagac tgtcccaagt cactacttat tccatacttg     1680

gataatttgg tgaaacatct gcattccatt atggtactga agcttcaaga gctgattcag     1740

aaaggcacca agttagtttt ggaacaagtt gtgacatcca ttgcatcagt tgccgatact     1800

gcagaagaaa aatttgtccc ctactatgat ttatttatgc catcactgaa gcacatcgtt     1860

gagaatgcgg ttcaaaaaga actgagactt ctgagaggaa aaactattga atgcattagc     1920

ctcattggtc tggctgttgg gaaggaaaaa ttcatgcagg atgcatcaga tgtgatgcag     1980

cttttgttaa agacccagac agacttcaat gatatggaag atgatgatcc tcagatctct     2040

tacatgatct cagcatgggc cagaatgtgc aaaatccttg gaaaagaatt tcagcaatac     2100

cttccagtgg ttatggggcc tttaatgaag acggcttcaa ttaagcccga agtagccctt     2160

ttagataccc aagacatgga gaatatgagt gatgatgatg gttgggaatt tgtgaacctt     2220

ggagatcagc aaagctttgg tattaaaact gcaggactag aagaaaaatc aactgcttgc     2280

cagatgttgg tttgctatgc taaggagtta aaggaaggct ttgtggagta caccgaacag     2340

gttgtcaaac tgatggtccc tttactgaaa ttttatttcc acgatggtgt tcgagtggca     2400

gcagcggaat ccatgcctct tctcctggag tgtgcaagag tccgtggtcc tgagtatctc     2460

acacagatgt ggcattttat gtgtgatgct ctaattaagg ccattggtac agaaccagat     2520

tcagacgtcc tctcagaaat aatgcattct tttgcaaagt gcattgaagt aatgggagat     2580

ggatgcctta ataatgaaca ctttgaagaa ctgggaggta tattgaaagc aaagcttgaa     2640

gaacatttta aaaatcaaga attacgacaa gttaaaagac aagatgaaga ctatgatgaa     2700

caggtcgaag agtcactaca agatgaggat gataatgatg tttatattct gaccaaagtg     2760

tcagatattt tacactcaat attcagtagc tacaaagaaa aggtgttacc atggtttgaa     2820

cagctgcttc cattaattgt caacctcatt tgtccacata gaccatggcc agacagacaa     2880

tggggattat gcatctttga tgatgtcata gaacactgta gtccagcctc atttaaatac     2940

gcagaatatt tcttaagacc aatgctccaa tatgtatgtg acaacagccc agaagtcagg     3000

caagcagctg catatggcct gggagtcatg gcacagtacg gtggagataa ttatcgccct     3060

ttttgtacag aagcacttcc cctgctggta agagttattc agtctgcgga ttctaagacc     3120

aaagaaaatg tcaatgctac agagaactgc atctcagcag tagggaaaat catgaagttc     3180

aagcctgact gtgtaaacgt tgaagaggtc cttccacact ggttgtcttg gcttccacta     3240

catgaagata aagaagaagc tgttcagact ttcaattatc tgtgtgacct gattgaaagt     3300

aatcatccaa ttgttcttgg cccaaacaat accaatctgc ccaaaatatt tagtataatt     3360

gcggaaggag aaatgcacga ggcaattaaa catgaagatc cttgtgccaa acgtctggcc     3420

aatgtcgttc gccaagtaca gacttctgga ggactgtgga ctgagtgcat agcacagctc     3480

agtcctgagc agcaggccgc cattcaggag ctcctgaact ctgcgtgaag ggccttaatg     3540

tcacccacca gaaaactaac tccaaataaa cgcttaccct ttcctttagg tttctttgtt     3600

ttgtttttga gcaaaagaga tcggtagtgt tgtgtgtagg ccattcttct ggagagccac     3660

aagcaggaag agcagcgctg tgttgcagaa tggagtttcc atggatttct accagaccac     3720

tgaaggagtt cctggaagcc ctgcggtagc tagcactgaa gactattttt ctattggtat     3780

aacccgccca cctgaagggg aaagggaaat caaattaatt tttctcgtta gacataagga     3840

aatttaagga aaaacagctt taagaacagt tactcagcgt agatgtgtgt tcacacaaat     3900

tgctctgcat tcagtgttca ttgtgaattg ggagtgtgag tctttctgta gggtagaaag     3960

aagcctccta cccagcaaac cagtagaccc aaaagttgaa aaaaactgat gacagacaac     4020

aagcatgaag atggcatatt tgatgtcact ttggttcttt ttcccagaag gcttatacag     4080

tgactcagtc gggaagcttt ccagcttcca gcccttgaat gtgaagtgtc attggcatgt     4140

ctggcagtag tctctcattc actcctcaat aaacaacatt gaatacaaaa gaggcttgtg     4200

taaaaactca gtactgtctg gcttggattc atttcatgtt tttaatataa gaatgatcta     4260

atattttttt aaagtaatag ctatcagtaa tagctgagtg ttttttcccc taatattttc     4320

cttgtgcaat tcagacttaa gcatcgagtt tttaccatct tccactttaa gctaagttat     4380

gatacctatt ccattcacaa ttggtgttct ttttaaggtt tgcaaatttc agccaatttt     4440

gtagctaaga ttgttctgat cagctcaaaa agatttggct tagtgttttc attgcaaatt     4500

ataattgctg tagagccaca cacaactttt gaacttttaa ttataagtgt tatggctaaa     4560

gttatttact gaaaatttca gtaaaatgtg tgaatgtttc tttatgtatt aacctcatag     4620

cagtaaatga cttgctgttg tttaattttt ctaaggcatc ttaatagact tctgttgaaa     4680

acttcagtgt taacattttt atagtttgta ctaaatttaa ccgtgatata aaaatgaatt     4740

ttatgcatag atcagaattt taaattaaag gttttttctt taaatgattt gtattacttt     4800

attaaaacta aatctgaaat ggaatagaaa atagaatgga ttacatacag atggtttcct     4860

tgttagcaga tgcccttcaa atatatttta cgtttgcagc acaacaccat tgcccggagg     4920

cttccgaatc tagcaaagca gcatattaaa tgactccacc tgcgcagtcc ttgtgttcag     4980

tggatgaata cctgtgggct cttgtaatgt gtggtaatat ttggagcttt atagcctgta     5040

ttccttggga gaaaaaaatg ggaattggag taaaaagtgt gtcaagacaa cccctttctg     5100

ctttcttatg tagcatctgc aaagccgatt catgtactga tgccaatcag ctagagcaat     5160

gtaggctttt tttaatttaa attattacta cactttatta ctacacttgc agaaaagaaa     5220

catgttaaaa tcatggcaca cctgcagaat ttcagatgac agtgtggtca gaagatgttt     5280

tttgggagaa cctagtgttt gctgggcact atgctaagca ctttgggagc aagaacctcc     5340

taccttccag tttaaacact agtggtattg tcagatgccg ttagtatctg agatgtactt     5400

acagcagggt tctaagagct ctgaaagaag cgctctgtta gatgcagact ggcagcatcc     5460

tccttgataa aagcagaaaa gcaaagaggt aattggagtt gaatcaagtt aatagggaag     5520

gttggtagta aatgctgtta gtgtgacatg attctgaaac ccagagctca gaactaactg     5580

tgagatgtac catgaactaa caattctttg aaaggacctg cagaagcatt tttaatacct     5640

cattctgtct atgcaagatg aaaatccatg gagttttttc ttggcttttg taccaaattt     5700

aggggtcttg catgtcagca agtgatatat attgtttata aatgcaagct atttctggag     5760

gggaaaaatg tgtgtggctc ttacgttttc tgggaatttt gtaacaagtt acacgcacaa     5820

gtgttagaaa ctttggcata actcaatttg gagtattttt taaatgctgt atctttaaag     5880

aaaagtaaaa ttgtcttaaa tctaattgac acttctgtaa tgagaggcaa ccttataact     5940

ctggagttgt agtttgacag aaccatcagt aaagacataa gcaaataaat ggtcttggtg     6000

cac                                                                   6003


<210> 383
<211> 2172
<212> DNA
<213> Homo sapiens

<400> 383
actgcgcgcg tcgtgcgtaa tgacgtcagc gccggcggag aatttcaaat tcgaacggct       60

ttggcgggcc gaggaaggac ctggtgtttt gatgaccgct gtcctgtcta gcagatactt      120

gcacggttta cagaaattcg gtccctgggt cgtgtcagga aactggaaaa aaggtcataa      180

gcatgaagcg cagttcagtt tccagcggtg gtgctggccg cctctccatg caggagttaa      240

gatcccagga tgtaaataaa caaggcctct atacccctca aaccaaagag aaaccaacct      300

ttggaaagtt gagtataaac aaaccgacat ctgaaagaaa agtctcgcta tttggcaaaa      360

gaactagtgg acatggatcc cggaatagtc aacttggtat attttccagt tctgagaaaa      420

tcaaggaccc gagaccactt aatgacaaag cattcattca gcagtgtatt cgacaactct      480

gtgagtttct tacagaaaat ggttatgcac ataatgtgtc catgaaatct ctacaagctc      540

cctctgttaa agacttcctg aagatcttca catttcttta tggcttcctg tgcccctcat      600

acgaacttcc tgacacaaag tttgaagaag aggttccaag aatctttaaa gaccttgggt      660

atccttttgc actatccaaa agctccatgt acacagtggg ggctcctcat acatggcctc      720

acattgtggc agccttagtt tggctaatag actgcatcaa gatacatact gccatgaaag      780

aaagctcacc tttatttgat gatgggcagc cttggggaga agaaactgaa gatggaatta      840

tgcataataa gttgtttttg gactacacca taaaatgcta tgagagtttt atgagtggtg      900

ccgacagctt tgatgagatg aatgcagagc tgcagtcaaa actgaaggat ttatttaatg      960

tggatgcttt taagctggaa tcattagaag caaaaaacag agcattgaat gaacagattg     1020

caagattgga acaagaaaga gaaaaagaac cgaatcgtct agagtcgttg agaaaactga     1080

aggcttcctt acaaggagat gttcaaaagt atcaggcata catgagcaat ttggagtctc     1140

attcagccat tcttgaccag aaattaaatg gtctcaatga ggaaattgct agagtagaac     1200

tagaatgtga aacaataaaa caggagaaca ctcgactaca gaatatcatt gacaaccaga     1260

agtactcagt tgcagacatt gagcgaataa atcatgaaag aaatgaattg cagcagacta     1320

ttaataaatt aaccaaggac ctggaagctg aacaacagaa gttgtggaat gaggagttaa     1380

aatatgccag aggcaaagaa gcgattgaaa cacaattagc agagtatcac aaattggcta     1440

gaaaattaaa acttattcct aaaggtgctg agaattccaa aggttatgac tttgaaatta     1500

agtttaatcc cgaggctggt gccaactgcc ttgtcaaata cagggctcaa gtttatgtac     1560

ctcttaagga actcctgaat gaaactgaag aagaaattaa taaagcccta aataaaaaaa     1620

tgggtttgga ggatacttta gaacaattga atgcaatgat aacagaaagc aagagaagtg     1680

tgagaactct gaaagaagaa gttcaaaagc tggatgatct ttaccaacaa aaaattaagg     1740

aagcagagga agaggatgaa aaatgtgcca gtgagcttga gtccttggag aaacacaagc     1800

acctgctaga aagtactgtt aaccaggggc tcagtgaagc tatgaatgaa ttagatgctg     1860

ttcagcggga ataccaacta gttgtgcaaa ccacgactga agaaagacga aaagtgggaa     1920

ataacttgca acgtctgtta gagatggttg ctacacatgt tgggtctgta gagaaacatc     1980

ttgaggagca gattgctaaa gttgatagag aatatgaaga atgcatgtca gaagatctct     2040

cggaaaatat taaagagatt agagataagt atgagaagaa agctactcta attaagtctt     2100

ctgaagaatg aagataaaat gttgatcatg tatatatatc catagtgaat aaaattgtct     2160

cagtaaagtg ta                                                         2172


<210> 384
<211> 5559
<212> DNA
<213> Homo sapiens

<400> 384
ggcattatgc aattatatta ctaaggctgc tacctgccca tgcccctctc ctcctcctgg       60

tttggaacta ccctccccat ctgctgctat atttatctgc cttcttggcc ataaaaggct      120

ggttgtgtgg cctgacattc gactgcctga ccacatgcat tatttttgaa ctggccccca      180

gggtcctgtc tttagccctg cctcttaaca ttgtcttgga ttcaacctag gtggagtctt      240

cattctctca tccagctcct cggcctcatc ggaacatttc caccaccatt actcctttgg      300

aaactggtgg cccggttcct tcaaggggca caggatgtct ttgccttttt atcagaggtg      360

ccaccagcac tatgatctca gctaccgcaa caaggacgtg cgcagcaccg tgagtcacta      420

ccagcgggag aagaaacgct ccgccgtcta cacccagggc tccacggcct acagcagccg      480

ctcctccgcc gcgcaccgcc gggagtccga ggccttccgt cgggcgtccg cctcctcctc      540

ccagcagcag gcctcgcagc acgccctgag ctctgaagtc agtcggaagg cagcctcagc      600

ctacgattat ggctcctccc atggacttac agattccagt ctgctgttag atgattattc      660

atccaagttg agccccaaac caaagagagc caagcacagc ctactgtctg gagaagagaa      720

agaaaatttg cccagtgact acatggtacc cattttctca ggacgtcaaa agcatgtcag      780

tggaattact gatacggaag aagaaagaat taaagaagct gctgcttata tagcccagag      840

gaatcttctt gctagtgagg aaggaatcac aacatctaaa cagtccacgg catccaagca      900

gaccacggca tctaagcagt ccacggcatc caagcagtcc acagcatcca agcagtccac      960

ggcatccagg cagtccacgg catccaggca gtctgtggtt tccaaacagg ccacatccgc     1020

tcttcaacag gaagaaactt ctgaaaagaa gtcaaggaaa gttgtgattc gagaaaaggc     1080

agaacgcctg tccctgagga aaacattaga agaaaccgag acatatcatg ccaagctgaa     1140

tgaagaccat cttctccatg ctcctgagtt tatcattaaa cctcgctccc acacggtttg     1200

ggagaaggag aatgtaaaat tgcattgctc catagcaggc tggccagaac ctcgtgtcac     1260

gtggtataaa aaccaggtgc caataaatgt ccatgcaaac cctggaaagt atattattga     1320

gagtcgatat gggatgcaca ctctggagat taatggatgt gattttgaag atacagctca     1380

gtaccgggcc tcggcgatga atgttaaagg agagctttcg gcatatgctt cagttgtggt     1440

aaaaaggtat aagggagagt ttgatgagac tcgcttccac gctggggctt ccaccatgcc     1500

cctcagcttt ggtgtgaccc catatggtta tgcatcccgg tttgagatcc actttgatga     1560

caaatttgat gtgtcttttg ggagagaggg agagacaatg agtctaggct gtcgtgttgt     1620

catcactcct gaaattaaac atttccagcc agagatccag tggtacagaa acggagtacc     1680

tctttctcca tcaaaatggg tgcaaacact ttggagtgga gagcgggcaa cgctgacatt     1740

ttcccatctc aacaaagaag atgaaggcct ctatacaatc cgtgtacgga tgggagaata     1800

ttatgaacaa tatagtgctt atgtctttgt tcgagatgct gatgcagaga ttgaaggagc     1860

cccagctgct cccttggatg tgaagtgctt ggaggccaac aaagattata tcatcatctc     1920

ctggaaacag ccagctgtcg atggagggag tcctattctc ggatatttta ttgataagtg     1980

tgaggtgggc acagatagct ggtcgcagtg caatgacaca cctgtgaagt ttgctcgttt     2040

tcctgtcact ggattgatcg aaggtcgttc ctatatcttc cgagttcgag ctgtgaataa     2100

aatgggaata ggtttcccat ctcgagtttc cgagcccgtg gctgctctgg atccggctga     2160

gaaagctaga cttaaaagtc gcccctcagc accctggact ggacagatca ttgttactga     2220

agaggaacct tcagagggta ttgtgcctgg ccccccgaca gacctctctg tcactgaggc     2280

cacccggagc tatgtggtgc tcagctggaa gccccctggc cagcgtggtc atgagggcat     2340

tatgtacttt gtggaaaagt gtgaggcagg aacagaaaac tggcagcgag tgaacacgga     2400

gctccctgtg aagtctcccc gctttgctct gtttgacttg gccgagggga aatcctactg     2460

tttccgtgtc cgctgttcta attctgcagg agttggtgag ccctcagagg caacggaggt     2520

gactgtggta ggggacaaac ttgatatccc caaggctcct ggcaaaatca tcccaagcag     2580

aaacacagac acctcagtgg tagtttcgtg ggaggagtcc aaagatgcca aagagctggt     2640

cgggtactac atagaggcga gcgttgctgg ctctggcaag tgggagccct gtaacaacaa     2700

ccccgtgaag ggctcacgat tcacttgtca tggattagtg actggtcaga gttatatttt     2760

ccgggtcaga gcagtcaatg cagctggact tagtgaatat tcccaggatt cagaagctat     2820

tgaagtcaaa gctgctattg caccaccatc tccaccctgt gatatcacct gtcttgaaag     2880

ttttcgtgac tcaatggttc ttggatggaa gcaaccagat aagattggag gggcagaaat     2940

tactggctat tatgtgaact atcgcgaggt cattgatggg gtaccaggaa aatggagaga     3000

agccaatgtc aaggctgtca gtgaggaggc atacaagatt agcaacttga aggaaaacat     3060

ggtgtatcag ttccaagtgg cagccatgaa catggctggg ctgggcgcgc cctccgcagt     3120

aagcgaatgc ttcaaatgtg aagagtggac catcgccgtc ccaggaccac cgcacagtct     3180

caagtgtagt gaagtcagga aagactcact ggttctccag tggaagccgc cagtccactc     3240

cgggcggact ccggtcactg gttacttcgt ggacttgaag gaggccaagg ccaaagaaga     3300

ccagtggcga gggctcaatg aggcggctat taaaaacgta tacctgaagg ttcgaggcct     3360

caaggagggc gtcagctacg tgttccgtgt tcgagccata aaccaggcgg gagttgggaa     3420

gccatctgac cttgctggcc ctgttgtggc agagacccgt ccaggaacca aagaggttgt     3480

tgtaaatgtg gatgatgatg gagtcatttc attgaacttc gagtgtgata agatgactcc     3540

aaagtccgag ttctcctggt ccaaagatta tgtatccact gaggactctc cacgattgga     3600

agtcgaaagc aagggcaaca agacgaaaat gaccttcaaa gaccttggga tggatgactt     3660

gggtatttac tcttgcgatg taacagacac tgatggaata gcatcaagct acttaataga     3720

tgaggaagaa ttgaaacgtt tacttgctct cagccatgaa cacaagttcc caactgtccc     3780

agttaaatca gagttggcag ttgaaatttt ggagaaaggc caggtccggt tttggatgca     3840

ggctgagaaa ctgtctggca atgccaaagt caactacata tttaacgaga aggaaatttt     3900

tgaaggcccg aaatataaaa tgcatattga ccgaaacact ggcatcatcg aaatgttcat     3960

ggaaaagcta caggatgagg atgagggaac gtacactttc cagcttcaag atggaaaagc     4020

aactaaccat tctactgttg ttctcgttgg agatgttttc aaaaagctcc agaaagaagc     4080

tgaattccag cggcaagaat ggatcaggaa acaaggtcct cactttgttg agtatttgag     4140

ctgggaagtg actggtgaat gtaatgtact attgaaatgc aaggtggcaa atattaagaa     4200

ggagactcat attgtgtggt acaaagatga gagggagata tcagtggatg aaaagcatga     4260

ctttaaggat ggtatatgta ccctgcttat aacagagttt tccaagaaag atgctgggat     4320

ttatgaagtt atcctgaaag atgaccgagg aaaagataag agcagactga agcttgtgga     4380

tgaagccttt aaggaactga tgatggaagt atgcaaaaaa atagctttgt ctgctacaga     4440

cctgaaaatc cagagcacag ccgagggcat ccaactgtac tcttttgtaa cttactatgt     4500

ggaggatttg aaagttaact ggtcccacaa tgggtccgcc attaggtact cagacagagt     4560

taagaccggg gtcactggag agcagatctg gctacaaatc aacgagccca ccccgaatga     4620

caaagggaag tatgtcatgg agctctttga tggcaaaact ggacatcaga agacagtgga     4680

tctctctgga caagcatacg atgaggccta tgctgaattc cagaggttga aacaagctgc     4740

cattgccgag aaaaatcgtg cccgggtgtt gggaggtctc ccagacgtgg tcaccatcca     4800

ggaggggaag gcccttaatc tcacttgcaa cgtgtgggga gacccgcctc cggaggtgtc     4860

gtggttgaag aacgagaagg ccctggcctc agacgaccac tgcaacctca agttcgaggc     4920

tgggaggacc gcgtacttca ccatcaacgg cgtgagcacc gctgactcgg gcaaatacgg     4980

gctggttgtg aagaacaagt atggctcgga gaccagcgac ttcaccgtca gcgtgttcat     5040

cccagaggag gaggcgagga tggccgcctt ggagtccctg aaaggtggca agaaggccaa     5100

gtgaccggag gtgcgaggag agccagccgg cctgtgtgac ttgggtgtga atggtttggg     5160

ttaaggatga gacgtcttca tgctttctcc tccctattat tttctggctt gaggggaaaa     5220

taatgtcagg tctttcactc atataaaaaa gcaccaacta atgacacttt aattgttttt     5280

ctttatctac aaaattatgt gttaagaaaa taccattcat agcatgaaga ttaggaaaca     5340

gttttaagga gaagacttga atgaagttgg agggacattg aatgatggtc agagggcaga     5400

cgaatgtgtc gtggggcgaa ttgggatttg ctgcagctgt gaagccatgg ccgtgtctcg     5460

tgtgttgtta cagaggtgat gtgcttttcg acgggcgcct cgtggcttgg aacctcctct     5520

gtatgaataa acagttttca cgtctgtcct cttccccga                            5559


<210> 385
<211> 3241
<212> DNA
<213> Homo sapiens

<400> 385
gatgctcagg ccaccgttcc cggcgcgcag tcgcagctga ccctcgctcc cgcccccgcc       60

tggagtccga cgtggaagtt gctggctgac tgggcttgcg aggaaaccgc ctcggagctg      120

cagccgaagg ccaaggaatc actgaagatc ggcgagggag gacagggggt tcatcatggg      180

tggctttttc tcaagtatat tttccagtct gtttggaact cgggaaatga gaattttaat      240

tttgggatta gatggagcag gaaaaaccac aattttgtac agattacaag tgggagaagt      300

tgttactact atacctacca ttggatttaa tgtagagacg gtgacgtaca aaaaccttaa      360

attccaagtc tgggatttag gaggacagac aagtatcagg ccatactgga gatgttacta      420

ttcaaacaca gatgcagtca tttatgtagt agacagttgt gaccgagacc gaattggcat      480

ttccaaatca gagttagttg ccatgttgga ggaagaagag ctgagaaaag ccattttagt      540

ggtgtttgca aataaacagg acatggaaca ggccatgact tcctcagaga tggcaaattc      600

acttgggtta cctgccttga aggaccgaaa atggcagata ttcaaaacgt cagcaaccaa      660

aggcaccggc cttgatgagg caatggaatg gttagttgaa acattaaaaa gcagacagta      720

attcagtcca ttcttctccc ctgaaatgaa gactacatca cctctctccc tttggaaaca      780

gtcaagtgta cttcacacta ctagatgtta aaactatatg attattggca tatactgact      840

gactgcaata tttgtagtaa atagggaaaa taagtattta gttggaggga taatttgatc      900

gaatcacctg aatgttctat gtaatgtaaa atattctttt cttgctttct tgtgttaagg      960

tatatattct atttgtatgg aattcttatt caaatacagt tctattaaag agtatactcc     1020

tattggatga aaaaaaccta tttttgaata gtagttgcag cttgtttgta taaatactaa     1080

aaaatatctt aacagatttt tttcccctta aaatgaatta tctttccaaa gattagactc     1140

agtatgagag taggtgagga acatagtttg tgtaatataa tctttatttg cttacctgac     1200

cactttttat taagctgttt tgtttaaaag cttttggtta taggcatgaa tattgttttg     1260

atggttaact tcactgactt atctgtaagt gtcattttat agtactttac agttgtcaaa     1320

aaaaatctta catatattga tctagttgat cggtagagga agcttgtgaa gtaggtagga     1380

caggttatga tgtcttcact gtatggacgt gaacccaggg ttctaatagg ttggcttgcc     1440

caaggtcacc tgctagcttg taaggtagga atagggctca aagtaaaact tttggttcag     1500

aagcttgact cataaactat actatatatt cccaaaaatg tcagtattga caacacagtc     1560

taactcttaa ataaaattat gctaattagt tacattcaaa ataatgttta taaatttatt     1620

tgtctatact agtagaagtg atcagtgaca tactataaat aatcctaaat ggttatattt     1680

gatagaattc ataacacatt aaagagaaaa tttcacatta aaggaaggtt taaaaatcta     1740

ttttcagatt ataaaaggtg tctttactgg ttttcattcc ttttatctac atgtaattgg     1800

acatgtaaac ttgttaaaaa tcaaaatctt actgattgta cagggagaaa ttaagcattc     1860

tgttttaaaa attaggctta ttgctagact gtaagtttaa aaacaattca tgttcaaagg     1920

agcttttcaa attacccagt ccaccacaga atcagctaat gtgacagaag taaatatagt     1980

gcgtcataat tgctaaaaac agggtgaatt tctttcactt aagttggaaa accagcctct     2040

aaaaaattag gtgctggtaa tgagagctta ataccatggt tccctgcagg tctcagaaac     2100

attagtagtt cctttcttgg ccctcactgt ccttccagtg ttggcctctg gcctcttccc     2160

ctcacattta tgttcattct ccgggcttat attcattctc tgctgctttc tcccttcacc     2220

cgtgggactc tcacccttct tgctcattct ccagcaccca ttcctacttt agtctctttg     2280

aaatcttttt tggagatttt ccttcagcta caaatgttcc agtacaacca atattactcc     2340

tgaggggcaa agactttttc atatttatgt ccctagtatc tggtatggcg cctggcatat     2400

ggcatttcag aatatgttca tagttgaaac agtaggatag atatttgtca tcttgacaag     2460

tagccctttg caatttatac ttgagttcac tcctggtcaa tggcacatgg ctggaaaatg     2520

cagaaagcaa gttcacttac agcctgaggc ttataaagct tgtacagctg cctcccggca     2580

gtccaggaaa actgcaaaaa atgggaagta aggtcctggc aggcagaccc ggcatgtagc     2640

cgctggccat cttgaatcct agggcatgaa gttgccccaa agttcagcac ttggttaagc     2700

ctgatccctc tggtttatca caaagaatag gatgggataa agaaagtgga cacttaaata     2760

agctataaat tatatggtcc ttgtctagca ggagacaact gcacaggtat actaccagcg     2820

tttggatatt gatatataca tggcaaatct gaatattgtt ttatgagagg cctggcaatg     2880

ggtaaaacac caaacttgaa atcagaacat aggtgcaaat ggccactcct gtagtttctt     2940

ttctgtaaaa tgggatctgg acgaatgata ccaaacgttt ctttctaaca ttgtatttta     3000

taactctggc ctatgattgt gttgtgtctt gcattaaaaa aaaaaatttg agagtggtag     3060

aattacttct gttatctgaa atacctgaga tgcactttaa actgttgaaa tgtaagctct     3120

gagggcaggg accgtatctt atttactgtt agtatccgtt gcatctagtg tggtgcacct     3180

ggcacacagt aggcactcaa taaatatgta ttgattaaaa acaaagacgt cttcaatatg     3240

c                                                                     3241


<210> 386
<211> 2937
<212> DNA
<213> Homo sapiens

<400> 386
cgtcggcggc cgcggccggg gacggtgtga gagcggtaag atggcggcgg cggcggtggt       60

ggagttccag agagcccagt ctctactcag caccgaccgg gaggcctcca tcgacatcct      120

ccactccatc gtgaagcgtg acattcagga aaacgatgaa gaggcagtgc aagtcaaaga      180

gcagagcatc ctggaactgg gatctctcct ggcaaagact ggacaagctg cagagcttgg      240

aggactcctg aagtatgtac gacccttctt gaattccatc agcaaggcta aagcagctcg      300

cctggtccga tctcttcttg atctgtttct tgatatggaa gcagctacag ggcaggaggt      360

cgagctgtgt ttagagtgca tcgaatgggc caagtcagag aaaagaactt tcttacgcca      420

agctttggag gcaagactgg tgtctttgta ctttgatacc aagaggtacc aggaagcatt      480

gcatttgggt tctcagctgc tgcgggagtt gaaaaagatg gacgacaaag ctcttttggt      540

ggaagtacag cttttagaaa gcaaaacata ccatgccctg agcaacctgc cgaaagcccg      600

agctgcctta acttctgctc gaaccacagc aaatgccatc tactgccccc ctaaattgca      660

ggccaccttg gacatgcagt cgggtattat ccatgcagca gaagagaagg actggaaaac      720

tgcgtactca tacttctatg aggcatttga gggttatgac tccatcgaca gccccaaggc      780

catcacatct ctgaagtaca tgttgctgtg caaaatcatg ctcaacaccc cagaagatgt      840

ccaggctttg gtgagcggga agcttgcact tcggtatgca gggaggcaga cagaagcatt      900

aaaatgcgtg gctcaggcta gcaagaacag atcactggca gattttgaaa aggctctgac      960

agattaccgg gcagagctcc gggatgaccc aatcatcagc acacacttgg ccaagttgta     1020

tgataactta ctagaacaga atctgatccg agtcattgag cctttttcca gagtacagat     1080

tgaacacata tctagtctca tcaaactctc caaggccgac gtggaaagga aattatcaca     1140

gatgattctt gacaagaaat ttcatgggat tttggaccag ggggagggtg tcctgattat     1200

tttcgatgaa cccccagtag ataaaactta cgaagctgct ctggaaacaa ttcagaacat     1260

gagcaaagta gtggattccc tctacaacaa agccaagaaa ctgacataga gttggatctg     1320

tagcggtcct ttggagagtg tgtgtggcgg gagagtgaaa ccttggggga aaatgctagg     1380

agattctttt ttctttttgt tctacttttc gctcggaaag tttttaaatc ctcatttggt     1440

gcatctgtat tccagccaat aggtgtgcca gttttcatgt aatctttact ggcccaactt     1500

gggagtgggg aaattgctta aaaaaaaaga aaaagaaaaa aaaaaagatt attctaaata     1560

aaaggaaaaa ggcttacact acctaaagct gtgctctctg cctcctggga gagggccgca     1620

aagccaggca ccccgccaac cactgggggt cctaatccac ctgctgggca tcacctctcc     1680

tcctcctcag aattgggtgt ttgctgacca tcaaaagcaa tgacttttta ttctgtttgt     1740

actgaaccaa aacaaacaac tgtgtataga ctgctgtttt cttttttatt tgaaatgagg     1800

cattttggtg ttctttcccc taccatacgg cctgtctgcc cttccctccc cacattggct     1860

ccagcagagt agccgaaggt cctgccgccg ccgccaccac caccaccact gcagcaacaa     1920

cagcagcagc agcagcagcg cctgcatagc tccactctga cctgtgaagg aatggggatg     1980

aggccaggag ctagtgtcta ccacggccac acagggagca gtgtgggccc ttagccccca     2040

aggggcctgc tatgcatgtg gctttttttt tttttttaaa cacagtaaac tagattagtc     2100

gtcagtgttt taattgcccc tcttctcctc tcctgcattc ctctcctctc ttctttcctc     2160

tctgtccctt ctctttcccc tctcaaccag gagaccatca tgtctctctg ccttcctcct     2220

ctcccctcca ggggagtcag gctgtctgtg aaagccatga gcttctctcc ctctcccact     2280

cctcctctcc tactttcaga tggatttatt ccttttttaa acaatgaaca tcggaaatga     2340

gactgtgggg tgtggtttct ctctctcttt tttttttaat tttctttgtt gggtttttga     2400

gcaacctcat gtccccttcc cagggagctt tttaatttac ctcttagaac tcaagtggat     2460

gggaagtaga gcactatgtg tcagtatgct ttgttttctg acacgattac acagcgaggc     2520

tttaatgcca tttgggtagg tgagcttctg cacttctgtt gtgctgaact gtattttctt     2580

ctctcatctc ctctttgtct ttttctcttt tcctctcctt cctgccttct tctgctggcc     2640

tccttttctc tttctttacc ttccttggat tatccttcca ggttttcata ataaatttat     2700

attttgtaaa aggattttgt tgtaccaggt tttgcatcct cactgaatct gactggcttt     2760

tattttcctc tccaaaatca ggtttttgtt ctcaacatct ttccccatca tgtctagtca     2820

ctgttttggt tttggcacca tcagtatcaa atgtacaaac ggttcttgct aaccaacacc     2880

aggtatatct gatgttcaga tgagttccaa taaaaataat tttttttttt ttcaaaa        2937


<210> 387
<211> 3297
<212> DNA
<213> Homo sapiens

<400> 387
agtcctgtta cacctcccgc ggccgcgcac agcggcaacc cgggcgtgcg ggggcgcgcg       60

cggtcaggga ggggcctgcg gaggcgcgag gcccccggaa gcgcctttcc cggaaggcag      120

ggaggcagcg ccggcctccg gaggcggcct gggcgatggc ggcggagttt tgtccataac      180

gtgggcaacc gcgcagctgg aggatggcct cactcgggcc tgccgcagct ggggagcagg      240

cgtcgggggc tgaggcggag ccgggccccg cggggccgcc gccgccgccc tcaccgtcct      300

ctctggggcc cctgctcccc ctgcagcggg aacctctcta caactggcag gcgaccaagg      360

cgtcgctgaa ggagcgcttc gccttcctct tcaactcgga gctgctgagc gatgtgcgct      420

tcgtactggg caagggtcgc ggcgccgccg ccgctggggg cccgcagcgc atccccgccc      480

accgcttcgt gctggcggcc ggcagcgccg tctttgacgc catgttcaac ggcggcatgg      540

ccaccacgtc ggccgagatc gagctgccgg acgtggagcc cgcagccttc ctggcgctgc      600

tgagatttct atattcagat gaagttcaaa ttggtccaga aacagttatg accactcttt      660

atactgccaa gaaatacgca gtcccagcct tggaagcaca ctgtgtagaa tttctcacca      720

aacatcttag ggcagataat gcctttatgt tacttactca ggctcgatta tttgatgaac      780

ctcagcttgc tagtctttgt ctagatacaa tagacaaaag cacaatggat gcaataagtg      840

cagaagggtt tactgatatt gatatagata cactctgtgc agttttagag agagacacac      900

tcagtattcg agaaagtcga ctttttggag ctgttgtacg ctgggcagaa gcagaatgtc      960

agagacaaca attacctgtg acttttggga ataaacaaaa agttctagga aaagcacttt     1020

ccttaatccg gttcccactg atgacaattg aggaatttgc agcaggtcct gctcaatctg     1080

gaattttgtc agatcgtgaa gtggtaaacc tctttcttca ttttactgtc aaccctaaac     1140

cccgagttga atacattgac cgaccaagat gctgtctcag gggaaaggaa tgctgcatca     1200

atagattcca gcaagtagaa agccgctggg gttacagtgg gacgagtgat cgaatcagat     1260

tcacagttaa tagaaggatc tctatagttg gatttggctt gtatggatct attcatggcc     1320

ctacagatta tcaagtgaat atacagatca ttgaatatga gaaaaagcaa accctgggac     1380

agaatgatac cggctttagt tgtgatggga cagctaacac attcagggtc atgttcaagg     1440

aacccataga gatcctgccc aatgtgtgct acacagcatg tgcaacactc aaaggtccag     1500

attcccacta tggcacaaaa ggattgaaga aagtagtgca tgagacacct gctgcaagca     1560

agactgtttt tttctttttt agttcccctg gcaataataa tggcacttca atagaagatg     1620

gacaaattcc agaaatcata ttttatacat aatttagcat tataatacat cttggctaaa     1680

taataccata caatctagtg tcaaaaacat aaatggccac aaaaaagtag tttgagtgtt     1740

atgaatattt aaaattgtaa gataagaaac agtttcttag agcagataga aaaatgctta     1800

tttaaatctt tgcatgattt aaaaacagat tttccatttt cttacaactt taagagaaaa     1860

gaactgggtt taatggttta aaaaaaagca cagctttttc accttcatct tgtataattt     1920

catagattgg ctgacttagg gtctttcaat agtttgggaa ttgaaagatt cttgttatat     1980

atagctagtt tgggtttgtt tttgttttaa ctattttgaa ggttaggtga gatgggcaaa     2040

taggcttaac tattttgaag gttggatgaa aagagatggg tcagtattcc tacagaattc     2100

ttattaactc aaataactaa atttcagaaa attaagaagc tgactttata tttggtggtt     2160

tgaagtatct tgttgttagc atttgtaata atgctaaaaa aggcctaata aaatgcccaa     2220

gaaaatattc agtgcattta tagagaagga tattttgtag tagtatagta atgtgttatg     2280

tagtacagtt ttaaagctat aaatggaatt ttgtgtaaat tcacaaaaat gtgatataaa     2340

caggatctaa gactggattc cctgtcacta aactgcacca ctatacctgt ctctctgtgt     2400

gggggacact gctgatgatt cccaagattg agatgatgac ggtgatgacg actgggtgaa     2460

cagccatcac ttcaacattg tgataatcct tcacagcaag aaaccgaata aaatactaac     2520

atttctaaca actgctctga cattgtaaag agatccaaca gaatcactcc tgctgaaaaa     2580

tacgctttct gccacctaca catttctatt taggaagtaa aatttgcttc atggtcatga     2640

ccccattagt cagtgttaca gctgtgttgg ggataggaag tatatctggc agattgatat     2700

ttatacactt ttttataaag cagattttaa aatatagtaa catccatttt tttcccttga     2760

aagtgattct cttataaaaa atgaaagtgg agtttaaggt atatcaaatc gttgtggaag     2820

gtgattaaaa atcaaaattc ttttaaatat caacttaatt ttttctaagt aagatacaaa     2880

aaattttcat ctaaagtaat atttcacttt atattgtaaa gaaggtaggt atattggtgg     2940

ctgaggtctc ttgaaattgc taaagggaaa tttttctatg gtaatgctct tacggatata     3000

aacctcagtt aaatggaatt atctatggga tgtgtggttc tggttaacta aaaattaacc     3060

agtaaacact ctgtagtaac cattacagaa aatacttctg ccttaaaaaa tatgatatgc     3120

cagagatgag ttagtgtttc ttgacgttgg agacctttta aatgcctcat ctgttgtact     3180

gaacaattga aactgcatgc agccataaaa gggacaagaa acagaactgt ttactaactt     3240

tgggacatcc cctggagttt ttaaaaataa ataaatatat atatatataa aaaaaac        3297


<210> 388
<211> 4194
<212> DNA
<213> Homo sapiens

<400> 388
cttccggaca ggtcaggcca aggtctcagc cacgtgactg tgttccggct cggtaaagat       60

ggcggcgccc agggcggtag cgtgaaactt ggtggaagac gctgaccagt cgtgttggaa      120

tcaaaacagc ggggaccctg cgccatgtcg cgactgatcg tgaagaatct cccgaatggg      180

atgaaggagg agcgtttcag gcagctgttt gccgccttcg gcacgctgac agactgcagc      240

ctgaagttca ccaaagatgg caagttccgc aagtttggtt ttattggctt caagtccgag      300

gaagaggccc agaaggcaca gaagcatttc aacaagagct tcatcgacac atcccggatc      360

acagtggagt tctgcaagtc attcggggac ccggccaaac ccagagcctg gagcaaacat      420

gcccagaaac caagccagcc caagcagcct ccaaaagact ctactactcc agaaattaag      480

aaagatgaga agaagaaaaa ggtggcaggt caactggaga agctgaagga ggatacagag      540

ttccaggagt ttctgtcagt tcatcagagg cgggcgcagg cagccacttg ggcgaatgat      600

ggcctggatg ctgagccctc gaaagggaag agcaagccgg ccagtgacta cctgaacttc      660

gactccgatt ctgggcagga gagtgaggag gagggagccg gggaggacct ggaagaagag      720

gcaagcctcg aaccaaaggc agctgtgcag aaggagctgt cggacatgga ttacctgaaa      780

tccaagatgg tgaaggctgg gtcgtcctct tcctcggagg aagaggaaag tgaagatgaa      840

gccgtgcact gtgatgaagg gagtgaggcc gaggaagagg attcctccgc caccccagtc      900

ctgcaggaaa gagacagcaa gggtgcaggc caagagcaag ggatgccagc tgggaaaaag      960

agaccaccgg aggccagagc cgagacagag aaaccagcaa accagaagga acccaccacc     1020

tgccacaccg tgaagctgcg gggagccccg ttcaatgtca cagagaaaaa tgttatggaa     1080

ttcctggcac ccctgaaacc agtggccatt cgaattgtga gaaacgctca tgggaataaa     1140

acaggataca tctttgtgga tttcagcaat gaagaggaag tgaagcaagc tctgaaatgc     1200

aaccgggagt acatgggtgg gcgctacatc gaggtgttca gggaaaagaa cgtccccacc     1260

accaagggtg caccaaagaa taccaccaaa tcctggcaag gccggatact cggggagaac     1320

gaagaggagg aggacctggc cgaatccgga aggctctttg tacggaacct gccctacacc     1380

agcaccgagg aggatctgga gaagctcttc tccaaatatg gtcccctgtc tgagctccac     1440

taccccatcg acagcctgac caagaaaccc aagggttttg cattcatcac cttcatgttc     1500

cctgagcacg ctgtgaaggc ctactcggag gtggacgggc aggtattcca gggcaggatg     1560

ctccacgtgt taccatctac catcaagaag gaagccagcg aggatgccag tgccctggga     1620

tcgtcgtcct acaagaagaa gaaggaggcc caggacaaag ccaacagtgc cagctctcac     1680

aactggaaca cactattcat ggggccgaat gccgtggccg atgccatcgc acagaagtac     1740

aacgccacca agagtcaagt gtttgaccac gagaccaagg gcagcgtggc cgtgcgcgtg     1800

gctctggggg aaacccagct cgtccaggaa gtgcggcgtt ttctcataga caacggggtc     1860

agcctggatt ccttcagcca ggctgcagca gagcgaagca agactgtgat tctggtcaag     1920

aacctcccgg caggcaccct ggcggcccag ctgcaggaga ccttcggcca ttttggcagc     1980

ctgggccgcg tgctgctgcc agagggcgga atcactgcca tcgtggagtt cctggagccc     2040

ctggaggccc gcaaggcctt caggcatctg gcctattcca agttccatca tgtccccctc     2100

tatctggagt gggctccagt tggcgtcttc tccagcacag ccccacagaa gaaaaagctc     2160

caagacacac cttcagaacc catggaaaag gacccagcag agccagaaac agtgcctgat     2220

ggcgaaaccc cagaagatga aaatccaaca gaggaaggag cagacaactc ttcagcaaag     2280

atggaagagg aggaggagga agaggaagaa gaagaagaga gcctcccagg atgtactctg     2340

tttattaaga atctcaattt tgacacaaca gaagagaagc tgaaggaagt gttttcaaaa     2400

gtggggacag tgaagagctg ctccatctcc aagaagaaga acaaagcagg agtgctcctt     2460

tccatggggt ttggatttgt ggaatacagg aagccggagc aagcccagaa agctctcaag     2520

cagctccagg gtcacgtcgt ggacggccac aagctggaag tgaggatctc ggaacgagcc     2580

actaagccag ccgtgacatt ggctcggaag aaacaagttc ccagaaagca gaccacctcc     2640

aagatcctgg tgcggaacat ccccttccag gcccacagcc gggagatccg agagctcttc     2700

agcacctttg gggagttgaa gacggtccgc ctgccaaaga agatgactgg gacaggcaca     2760

cacagaggct tcggctttgt ggacttcctc accaagcagg atgcgaagag agccttcaac     2820

gccctgtgtc acagcaccca cttgtacggg cggaggctgg tgctggagtg ggccgactcc     2880

gaggtgaccc tgcaggccct gcggcggaag acggccgctc actttcacga gcccccgaag     2940

aaaaagcggt ctgtggtgtt ggacgagatc ctggagcagc tggaaggcag tgacagcgac     3000

agcgaggagc agacccttca gctgtgagct ggcaccgaga gggtgtgtgg ctccggggcc     3060

ctggggaccg ggacagccgc tccagcttct gcactcacca ccatgtgggc tggggggcgg     3120

ggcggggagc ggcaggcggc cccaccctgc actggtccaa ggtcggagga gacaggggat     3180

gaggaaggcc tcaggccact gcccagcggc ccaggcatcc tgggtttcac cagtgacgcg     3240

ttctagcaga cactgactgc gcacctgctc tgtagcagac acggaagagt ccaagggagc     3300

agccacgtta ggaagagaga cttgggaaca gctacacagg gagctagaac ccctgctccc     3360

cctgtcccca ccccaggaga gtaaggggac gagggccagc tctctggcat caggctgctt     3420

ggacatgaaa ccccgtctcc aagctcaagc tgggagaccc tggcccagtt tccttatctc     3480

cttgggccca gccttcccct tgctagctag ttcttacttc ataaggtttt agagagaaat     3540

aaacgcagta atgcatgaag agtgccgggc atggtgctga gccctgttcc tgctctccct     3600

ccagggctgc tgagctagaa ttcccaccta tgtctttcca agggactgtt cacggcttgg     3660

gacttggtct ctgtcctgcc ccatcctcgt cacttgggac cacgagccct ggttcagtca     3720

cccagggaag cctcccagcg gctcatgaag catcgagctc caagcccaga tgccaagctc     3780

cctggctgag ctgaatgatg tcactcatgg tggacgcgtt ctgctcacgg gcccagagcc     3840

ctgtgaaatg catcaaggtc ctctccgctg gccagcagca tccccaggct tctctcaggc     3900

gcccgtgttc acattttctc cagcctgaga cgcagcctcc cgcctggaag ggcctgtgcc     3960

agcaccaggc agagggcaag acggagaggg cagagcaaga actgcactgc atctcactgc     4020

agtctgaatc tagacatcgc cattccccga ggtgcgacct cagactaatg acatcctggc     4080

tgagcctctg tttttctctc taggaaatgg gggtgataat tgtgcctacc tcagatagac     4140

agtgccagaa ttaagtgagt caagccaagt aaagcccaga gaagattctc atca           4194


<210> 389
<211> 6003
<212> DNA
<213> Homo sapiens

<400> 389
agtgactcgg aagactttaa cagcaacagc tgcctcctct tgccagcttg atcccacctg       60

ctaagtgaag gaacagcgtt taaagaggtg gcaatcggca agggtggatg cttccctttc      120

cgcgcaggcg cgttcagtcg cagcaccgcg actatcgtga tagacaagcg agatcgacgc      180

tggcccttta atagcccttt cccggggtcc tgccccgcgc gtgcgcactg tggttctgcg      240

cttgtcatca tggcgacgcg gggccatgtg caggacccta acgacaggcg cctccggccc      300

atttacgatt atcttgacaa tggtaataat aaaatggcaa ttcagcaagc agataaactg      360

ttgaagaaac ataaggatct tcattgtgct aaggttttaa aggcaattgg tttacagaga      420

actggaaagc aagaggaagc ctttactctt gcacaggagg tggcagccct tgaacccaca      480

gatgacaact cactgcaggc actgactatc ctttaccggg agatgcaccg accggagtta      540

gttacaaaac tttatgaggc agctgtgaag aaagttccca atagtgagga gtatcactct      600

cacctcttca tggcctatgc cagagtgggt gaatacaaga aaatgcaaca ggctggcatg      660

gctctatata agattgtccc caaaaatccc tactactttt ggtctgtgat gagcttaatt      720

atgcaatcta tatcggcaca ggatgaaaac ctctcaaaaa caatgtttct gccccttgct      780

gagagaatgg tcgaaaaaat ggtgaaagag gacaagatag aagctgaggc tgaagttgaa      840

ctttattata tgatcctgga acgtttggga aagtaccagg aggccttgga tgtcatcaga      900

gggaaattag gagagaagtt gacaagtgag attcagagtc gggaaaataa atgcatggct      960

atgtacaaga agctgagcag gtggccagag tgcaatgccc tttcccggcg cctcttacta     1020

aaaaactcag atgactggca gttctatctg acttatttcg attctgtctt tcgactgatt     1080

gaagaggcct ggagtcctcc tgctgaaggt gaacactctt tagaaggaga agtacattat     1140

tctgcagaaa aagctgtgaa gtttatagaa gatcggataa cggaagaatc taaaagttct     1200

cgccatctcc gaggaccaca tctagctaaa ttggagctga ttaggcgttt acgaagtcaa     1260

ggttgtaacg atgagtacaa actgggtgat ccagaagaat taatgttcca gtattttaaa     1320

aagtttggcg ataaaccttg ttgttttaca gaccttaagg tgtttgttga cctcttacct     1380

gctacacagt gtacaaaatt tattaatcag ttacttggag ttgttccttt gtcgacacca     1440

acagaggata agctggcact gcctgctgac atcagagctc tgcagcaaca tttgtgtgtg     1500

gtgcagctga cgaggttact tggcttgtac cacaccatgg ataaaaatca gaaattgagt     1560

gtggtcagag aattgatgtt aaggtaccag catggactgg aatttgggaa aacctgtttg     1620

aaaacagaat tgcaattttc tgactattac tgtctccttg ctgtccatgc gcttattgat     1680

gtatggaggg aaacaggtga tgagaccact gtgtggcagg ccctgacttt gctggaagag     1740

ggattaaccc atagcccttc caatgctcag ttcaaattgc tgcttgttcg aatctactgt     1800

atgctgggtg catttgaacc agtggtggat ctttactcca gcctcgatgc taagcatatc     1860

cagcatgata ccattggtta tcttttgacc cgatatgctg aatctctagg tcagtatgct     1920

gctgcgtccc aatcctgtaa cttcgcactc aggttttttc actccaacca gaaagatacc     1980

tcagaatata ttattcaagc ttacaaatat ggtgcatttg agaagatccc agagtttatc     2040

gcttttagga acaggctgaa taattctctt cattttgcac aagtccgtac tgaacggatg     2100

ctgttagacc ttctacttga agcaaatata tcaaccagtt tagcagaaag tataaagtca     2160

atgaacctta ggccagaaga agatgacatt ccatgggaag atttgcgaga caacagagac     2220

ttaaatgttt ttttcagctg ggatccaaaa gacagggacg tttctgaaga acataagaaa     2280

ctttccttag aggaggagac cttgtggtta agaatccgat ccttaacatt gaggctgata     2340

agtggacttc caagtctcaa ccaccctgtg gagccaaaga actcggagaa gactgccgag     2400

aatggggtat cctcccggat tgatattctt cgtttgctcc ttcaacagct ggaggcaacc     2460

ctggagacag gaaagcgatt tattgagaag gatattcagt atcctttcct tggtcctgta     2520

cctaccagaa tgggtggatt ctttaattct ggctgttctc agtgccagat aagctctttt     2580

tatcttgtca atgatattta tgagctggat accagtggtt tagaggatac aatggagatt     2640

caggaacgaa tagaaaatag ttttaagtct ttactagacc agttaaaaga tgtcttcagt     2700

aaatgtaaag gtgacctctt agaagttaaa gatggtaact tgaaaacaca tcctactctt     2760

ttagaaaatc tagttttctt tgttgagact atttctgtta tcctttgggt atccagttac     2820

tgtgagagtg tcctacgacc atacaaacta aatttacaga aaaagaaaaa gaagaaaaaa     2880

gaaaccagca tcatcatgcc acctgtcttt accagtttcc aagactatgt tactgggctt     2940

cagactttaa tttccaatgt tgtggatcat attaaagggc ttgaaacaca tctaattgca     3000

cttaaacttg aagaacttat tttagaagac acttctctct caccggaaga gagaaaattt     3060

tcaaagactg tgcaagggaa ggtgcagagc agttatctgc actcacttct ggaaatgggg     3120

gagctgctga aaaaaagact tgagaccaca aagaaactaa aaatttaagg aagtatctat     3180

catgggcact gatgactctg caacagaata tgacaccatc ttcccaggca aaagcaacat     3240

ctggttgacc atgattttaa tccagaactt cctcataaaa tgcatgaagg actttgatcg     3300

tgaatttttt taggtgttaa atatatacaa ctgattaaat tattgtatat aaaccagaag     3360

cgggaccctc atctgggttt gaccactttt tatacatgtt catatgcata tggcagcaac     3420

aagagaaccc tacttttctt cttcccatca ccagaaacat cttttcaggg gagcgggggg     3480

tctataaaaa cagcaataga aattaagcat aaagcatcaa cctcatagca actgaatagc     3540

ccttccatta taaataacat tgagagtttt tggtctggtc cttgagccac aagaagtgga     3600

ggggagacca tgcctgggaa cagaccccct tttcacagca gtaagtttgt tttgaggctt     3660

tctcagctac ttggctccca cagaacccaa ggcaggtaca caaaggacct tagatgagat     3720

ctggcatatg cacccgcaat agaagggcac cacttggatg accacaggca cttagttttt     3780

ggctagtttt tgtctgatag ttaagacatc cccatcctag cttctgtgag agttaaaaat     3840

ctcaggtaag aaggcaagga aggctctgtt aatttatagc tgtttagagg ggaaagcagt     3900

gcagaccact tattaagccc gctgaggact agctttctgt ctttcataca tttgggaaag     3960

ataggaatga ctgtttcaaa gaagagaggt gcacataatt tatgcaggca agtatgatac     4020

ttatttcatt ggttttgtga gtcatatata tacatatata tatatacaca tatatatatg     4080

acttgaaaat taagatttaa tactttaatg ttttaagtgt ggggggtttg ggaaggaagg     4140

aatgtaatat tatggattta gccttaggct ttaagtttta ggctggcaaa agaaatgtta     4200

ttcagtgggt ttgaggtttg gactactttc ttcaaactta gagaattata acaggatggt     4260

gtttactttg ttcacctgga tgtccccaag actctagctt cttctatcag tggttggtct     4320

gatagaagag gtaaaaattg ctcttgaaaa tgtcctacaa tttatgcagt ttctttgata     4380

atatttttct gtttaaatcc ctgcttctgt ttttggtctg ttacctaaat atagttcaag     4440

tttaattctg taagagcaaa gaaatgaatt tgatgaggaa attaagcatc caatggagga     4500

ttggtcttga agaccttaaa ggtgctttcc aacctgcact gctccagtga aatgtggtac     4560

ttttttcttt taaaagcaac caagagagct gggaatatct gtgtacgcaa agtaattgca     4620

ttttgtccct tcattttgac tttcttagat tcataatttg atacagtgct taaacttcca     4680

aggaaatttt aaacaattac tacattacct gttcaaaata aggcttgttg gaaatcctag     4740

tccatcaact aatttcaaaa atttattttt gatatgagta gcaacagctg gtcatatacc     4800

ctatcccaaa aggaagaact gtcttgaaca agatgaatgg aaaattgtgg ttaattctga     4860

atttcatgta atgacaacat attctttcat aaaactatgg cctgtttaag atggaacttt     4920

gtgtgtgtct gctggggagg gtggggtaca tgtgtatggc gtgtgttctt gaaatgatgt     4980

ctctctgaat atccaaaaaa gtactgtact gtagaaatgc tctttgaaaa agtctatcga     5040

ctgaccatga tcaatctagc atatgtatgt tcagtgggct agccttggtc ctcagggaca     5100

gtgtgtgact ctagtggtct tcctaaccag tctcttgcct aaagatatct gggacctcta     5160

ctggctttaa tgacaaataa tgttatgttg aggttatgct tcctttgtta tttgctgatt     5220

ttcctactaa atgtagcatt tcaattagat ccagctttca cattttgaga taattgtaaa     5280

aagaatgaaa ttatgcagaa atggccaata tctcttatca atctgttctt ttggaaaccc     5340

tcatgtacta taaattgtgt acagttaaaa aaatatatat atatatatat tcttacatga     5400

gtaaaaagca ccctctccca gcaatcgtat gccattggta tttgaagaga attcccaaat     5460

aacccattgc tgctgctgct gtttttgatt tgtatgggtt tttttgtttt gtttgttttt     5520

gtgtggtaaa ctgatattta aaaaaggaaa ggagaaaaat cacgactact gtttacagac     5580

tgaaaaatta ttgcttttta tactactgag atcctaagtt aagactctcc aaagcaaaca     5640

tttggtttaa atcatttatc tgatgtagat aaaaggtaga gaaacttgta gtgttctcca     5700

cataatggaa aatgtacaaa tgcctagttg tgttgcccat caattttgta tattttcata     5760

attttaattg ttgaaaattg cattatattt tgcaatcact atgttcaatc tggatttgtc     5820

tttcatttta acttttaata taaaaagggg tttcaatgta tctacaggct tgttattgaa     5880

acttcctact tatttgatgt gatttattaa tataggaagt atatattctt ccttaagtaa     5940

gtgaagcata gcaaatctac tttaaactgg atgggttaat ttatataaac attttcattt     6000

taa                                                                   6003


<210> 390
<211> 4238
<212> DNA
<213> Homo sapiens

<400> 390
cgcgaagccc cgccccctct tcctcgccct ctctcgcggg tcggggttac atggcggcga       60

ctgcggcaaa gcgagagcct cggagacgcc gctgccgcca gcacagccgg agacctgagc      120

cgacactggg ggcagtccgc gagccccgca ctctctcgat gagtcggaga agtcccgttg      180

tatcagagta agatggacgg tagctttgat tgtgattgtg gtgagctgga gccacctgat      240

cactaacaaa agacatcttc tgttaaccaa cagccgccag ggcttcctgt tgaaataaat      300

atatagcaac aaaggaaaaa aagaagcaaa acggaaatag tgcttaccag caccttagaa      360

tgatgctgct caggaccagt ccaacactga atgtatctgc actgtgagga gaatgttcat      420

agaagcctgt tgtgtgcata tttattcaca tttttgttaa atgttaaatc gtttagcacg      480

gtaatctgag tgcacagtat gtcatttcat tccgtttgag tttcttgttt tcgttaaatg      540

tctgcagagt tgctgcccct ttcttgaact atgagtactg caatcttttt aattctcaat      600

atgaatagag ctttttgagc tttaaatcta aggggaactc gacaggcctg tttggcatat      660

gcaatgaaca tcaagaaacc atcttgctgt ggaagcataa ttatttttct tctccctttt      720

tgaaagatct ttccttttga tgccagtttt cttccttgtt tacacaagtt caatttgaaa      780

ggaaaaggca atagtaaggg tttcaaaatg gcagagaaat ttgaaagtct catgaacatt      840

catggttttg atctgggttc taggtatatg gacttaaaac cattgggttg tggaggcaat      900

ggcttggttt tttctgctgt agacaatgac tgtgacaaaa gagtagccat caagaaaatt      960

gtccttactg atccccagag tgtcaaacat gctctacgtg aaatcaaaat tattagaaga     1020

cttgaccatg ataacattgt gaaagtgttt gagattcttg gtcccagtgg aagccaatta     1080

acagacgatg tgggctctct tacggaactg aacagtgttt acattgttca ggagtacatg     1140

gagacagact tggctaatgt gctggagcag ggccctttac tggaagagca tgccaggctt     1200

ttcatgtatc agctgctacg ggggctcaag tatattcact ctgcaaatgt actgcacaga     1260

gatctcaaac cagctaatct tttcattaat acggaagact tggtgctgaa gataggtgac     1320

tttggtcttg cacggatcat ggatcctcat tattcccata agggtcatct ttctgaagga     1380

ttggttacta aatggtacag atctccacgt cttttacttt ctcctaataa ttatactaaa     1440

gccattgaca tgtgggctgc aggctgcatc tttgctgaaa tgctgactgg taaaaccctt     1500

tttgcaggtg cacatgaact tgaacagatg cagctgattt tagaatctat tcctgttgta     1560

catgaggaag atcgtcagga gcttctcagc gtaattccag tttacattag aaatgacatg     1620

actgagccac acaaaccttt aactcagctg cttccaggaa ttagtcgaga agcactggat     1680

ttcctggaac aaattttgac atttagcccc atggatcggt taacagcaga agaagcactc     1740

tcccatcctt acatgagcat atattctttt ccaatggatg agccaatttc aagccatcct     1800

tttcatattg aagatgaagt tgatgatatt ttgcttatgg atgaaactca cagtcacatt     1860

tataactggg aaaggtatca tgattgtcag ttttcagagc atgattggcc tgtacataac     1920

aactttgata ttgatgaagt tcagcttgat ccaagagctc tgtccgatgt cactgatgaa     1980

gaagaagtac aagttgatcc ccgaaaatat ttggatggag atcgggaaaa gtatctggag     2040

gatcctgctt ttgataccaa ttactctact gagccttgtt ggcaatactc agatcatcat     2100

gaaaacaaat attgtgatct ggagtgtagc catacttgta actacaaaac gaggtcatca     2160

tcatatttag ataacttagt ttggagagag agtgaagtta accattacta tgaacccaag     2220

cttattatag atctttccaa ttggaaagaa caaagcaaag aaaaatctga taagaaaggc     2280

aaatcaaaat gtgaaaggaa tggattggtt aaagcccaga tagcgctaga ggaagcatca     2340

cagcaactgg ctggaaaaga aagggaaaag aatcagggat ttgattttga ttcctttatt     2400

gcaggaacta ttcagcttag ttcccagcat gagcctactg atgttgttga taaattaaat     2460

gacttgaata gctcagtgtc ccaactagaa ttgaaaagtt tgatatcaaa gtcagtaagc     2520

caagaaaaac aggaaaaagg aatggcaaat ctggctcaat tagaagcctt gtaccagtct     2580

tcttgggaca gccagtttgt gagtggtggg gaggactgtt ttttcataaa tcagttttgt     2640

gaggtaagga aggatgaaca agttgagaag gaaaacactt acactagtta cttggacaag     2700

ttctttagca ggaaagaaga tactgaaatg ctagaaactg agccagtaga ggatgggaag     2760

cttggggaga gaggacatga ggaaggattt ctgaacaaca gtggggagtt cctctttaac     2820

aagcagctcg agtccatagg catcccacag tttcacagtc cagttgggtc accacttaag     2880

tcaatacagg ccacattaac accttctgct atgaaatctt cccctcaaat tcctcatcaa     2940

acatacagca gcattctgaa acatctgaac taaaacactc agcagacatt tatctttgta     3000

ttcttcatga aatgtgtttt gtcttttttt attactagtg tttaagtcat tttttacttg     3060

aatcagatgg tgtcatttag taaggatttt atgagttctt gttttttaaa atccagactt     3120

tctttttcta catgtgagat agttttcatt ttaactggca tgtcatttgc acacaaaaat     3180

aaagactaga gcaaaataat gcaacgcagg aggagaaaag aaatgcacta agacaagaac     3240

attctctcat agaacattga tctgttttac aggaaacaaa ccttgccttg aaatttacac     3300

agtgagactg tacataattg catgaaaata gctatttttt tcctaagaca tttttcattc     3360

atgaatattt tcaagttttt catactgtac acatttctta aaacacatga taccagcagc     3420

aactgaaaat gaatgccgaa tttggtacac atgtgttatc tacctcaagg taacaagagt     3480

atgtggcaaa acatatacca cccatagtgc ttcacaaaat gcacttctat ttagccagcg     3540

tttattgtag taaactattc ttaataaaac tcactcactg tttataaatg ttctggtatg     3600

cattctttat agtgaagtgt taatacatca catcttattt attttagcaa atcagtatat     3660

tttctgtatt taattataaa aaattaactt agtttttaaa atttatttgc aaatatactt     3720

tactttttcc atttggcact atggtttgtt gcctacctag ctgcatctat aatgtcagct     3780

tatcctaagg ctgtccacgt acttaattta cttaagtgtt cattttaagt aacgtgctca     3840

ctgtgtatag gaatttgtat tttggaggtg cttgatctat ctacaaagaa aaattaatta     3900

ggaattactt tattataaaa tgctcctaga agtcttaatt gtgtttattt tttaaaaaaa     3960

caaatgttag acttgtgtgc atggaagtaa ttaaggtaca tcattattgt agtttgaaag     4020

ttgtacatga taagacattt tgtttttact gtatgttttt actgaatgat ctattcccca     4080

tcccaaggca agcatgaata aaattaggtt aaacgtagca tgtggcatcg cagtctctta     4140

gaatttgttt catctatttt attttattga atactgtctg tatctttggt tatcctgttt     4200

gaagaaaaag gacaaataaa acatggccag caaataca                             4238


<210> 391
<211> 2841
<212> DNA
<213> Homo sapiens

<400> 391
attccgagaa cgccctctcc ggcctgtctc cccctcgcgc cggcggccgt ggtgcagccc       60

aaggcggaag cggctgcctg acggaaccgg ctcgcgagcg cagctatggc tgctggcgta      120

ccctgtgcgt tagtcaccag ctgctcctcc gtcttctcag gagaccagct ggtccaacat      180

atccttggaa cagaagatct tattgtggaa gtgacttcca atgatgctgt gagattttat      240

ccctggacca ttgataataa atactattca gcagacatca atctatgtgt ggtgccaaac      300

aaatttcttg ttactgcaga gattgcagaa tctgtccaag catttgtggt ttactttgac      360

agcacacaaa aatcgggcct tgatagtgtc tcctcatggc ttccactggc aaaagcatgg      420

ttacctgagg tgatgatctt ggtctgcgat agagtgtctg aagatggtat aaaccgacaa      480

aaagctcaag aatggtgcat caaacatggc tttgaattgg tagaacttag tccagaggag      540

ttgcctgagg aggatgatga cttcccagaa tctacaggag taaagcgaat tgtccaagcc      600

ctgaatgcca atgtgtggtc caatgtagtg atgaagaatg ataggaacca aggctttagc      660

cttctcaact cattgactgg aacaaaccat agcattgggt cagcagatcc ctgtcaccca      720

gagcaacccc atttgccagc agcagatagt actgaatccc tctctgatca tcggggtggt      780

gcatctaaca caacagatgc ccaggttgat agcattgtgg atcccatgtt agatctggat      840

attcaagaat tagccagtct taccactgga ggaggagatg tggagaattt tgaaagactc      900

ttttcaaagt taaaggaaat gaaagacaag gctgcgacgc ttcctcatga gcaaagaaaa      960

gtgcatgcag aaaaggtggc caaagcattc tggatggcaa tcgggggaga cagagatgaa     1020

attgaaggcc tttcatctga tgaagagcac tgaattattc atactagggt ttgaccaaca     1080

aagatgctag ctgtctctga gatacctctc tactcagccc agtcatattt tgccaaaatt     1140

gcccttatca tgttggctgc ctgacttgtt tatagggtcc ccttaatttt agtttttagt     1200

aggaggttaa ggagaaatct tttttttcct cagtatattg taagagagtg aggaatacag     1260

tgatagtaat gagtgaggat ttcttaaata tacttttttt ttgttctagg aatgagggta     1320

ggataaatct cagaggtctg tgtgatttac tcaagttgaa gacaacctcc aggccattcc     1380

tggtcaacct tttaagtagc atttccagca ttcacacttg atactgcaca tcaggagttg     1440

tgtcaccttt cctgggtgat ttgggttttc tccattcaag gagcttgtag ctctgagcta     1500

tgatgctttt attgggagga aaggaggcag ctgcagaatt gatgtgagct atgtggggcc     1560

gaagtctcag cccgcagcta agtctctacc taagaaaatg cctctgggca ttcttttgaa     1620

gtatagtgtc tgagctcatg ctagaaagaa tcaaaaagcc agtgtggatt tttagactgt     1680

aataaatgag gcaaaggatt tctattccag tgggaagaaa acctctctac tgagttgtgg     1740

gggatatgtt gtatgttaga gagaacctta aggagtcctt gtatgggcca tggagacagt     1800

atgtgataac ataccgtgat tttcatgaag aaattcttct gtcttagagt tctcccctgc     1860

tgcttgagat gccagagctg tgttgttgca cacctgcaaa acaaggcaca tttccccctt     1920

tctctttaaa gccaaagaga gatcactgcc aaagtgggag cactaagggg tgggtgggga     1980

agtgaaatgt taggcgatga attcctgagc accttgtttt tcttccaagg ttcgtagctc     2040

ctctctgccc ttccaagcct gtaacctcgg aggactatct tttgttcttt atcctttgtc     2100

ttgtttgagt gggtcagccc cagaggaact gataagcaaa tggcaagttt ttaaaggaag     2160

agtggaaagt actgcaaata aaaatcctta tttgtttttg tagactttgt aatgcatatc     2220

attagccctc actgtgatca ttactgctgt ggctctgaac tggcacatag tacagtggat     2280

ggaaggtgcc cgcacaccag ctgagaactg gttctggcct aggtgggctc tagaaccatt     2340

tacacagcat gaaagaaaca ggttgggtta ggagcagaaa gaaataaggc tcacacccct     2400

ccagacacta ccttataagc actgcagaac ctgaaacaga tggcagaagg aatggaatgc     2460

tacaggggcc agcaggagtg accacaggga ggggacagct cagtgactgg agcattcagg     2520

aagaggcttt ccagggaaca ctggacattg cttagtgacc ttttgttcct tttttttttt     2580

ttttctttta ctgttctgaa agactttgag tctgtggttc accaccagcc catcagtgtt     2640

tctttgaggt gattgcatta gggaagttgg ctctgggatt gcaaaaaaaa aaaaaaggtg     2700

gaacatgttt tccttaaaag atggaaggtt ttagaaaata tactaggcca tctggttaga     2760

aaaaacagac cagactagaa aaagctgtga atttgatttt gtagattaaa caaagccaga     2820

tgattaaaat gtgatttatt t                                               2841


<210> 392
<211> 4515
<212> DNA
<213> Homo sapiens

<400> 392
agttccggcg ggtgacggtg cggacgggtc aggagcgtag aggcggcggc aaaatggcgg       60

cgcctgagga gcgggatcta acccaggagc agacagagaa gctgctgcag tttcaggatc      120

tcactggcat cgaatctatg gatcagtgtc gccatacctt ggaacagcat aactggaaca      180

tagaggctgc tgtacaggac agattgaatg agcaagaggg cgtacctagt gttttcaacc      240

cacctccatc acgacccctg caggttaata cagctgacca caggatctac agctatgttg      300

tctcaagacc tcaaccaagg gggctgcttg gatggggtta ttacttgata atgcttccat      360

tccggtttac ctattacacg atacttgata tatttaggtt tgctcttcgt tttatacggc      420

ctgaccctcg cagccgggtc actgaccccg ttggggacat tgtttcattt atgcactctt      480

ttgaagagaa atatgggagg gcacaccctg tcttctacca gggaacgtac agccaggcac      540

ttaacgatgc caaaagggag cttcgctttc ttttggttta tcttcatgga gatgatcacc      600

aggactctga tgagttttgt cgcaacacac tctgtgcacc tgaagttatt tcactaataa      660

acactaggat gctcttctgg gcatgctcta caaacaaacc tgagggatac agggtctcac      720

aggctttacg agagaacacc tatccattcc tggccatgat tatgctgaag gatcgaagga      780

tgactgtggt gggacggcta gaaggcctca ttcaacctga tgacctcatt aaccaactga      840

catttatcat ggatgctaac cagacttacc tggtgtcaga acgcctagaa agggaagaaa      900

gaaaccagac ccaagtgctg agacaacagc aggatgaggc ctacctggcc tctctcagag      960

ctgaccagga gaaagaaaga aagaaacggg aggagcggga gcgtaagcgg cggaaggagg     1020

aggaggtgca acagcaaaag ttggcagagg agagacggcg gcagaattta caggaggaaa     1080

aggaaaggaa gttggaatgc ctgccccctg aaccttcccc tgatgaccct gaaagtgtca     1140

agatcatctt caaattacct aatgattctc gagtagagag acgattccac ttttcacagt     1200

ctctaacagt aatccacgac ttcttattct ccttgaagga aagcccagaa aagtttcaga     1260

ttgaagccaa ttttcccagg cgagtgctgc cctgcatccc ttcagaggag tggcccaatc     1320

cccctacgct acaggaggcc ggactcagcc acacagaagt tctttttgtt caggacctaa     1380

ctgacgaatg acattttttt cttcctgtcc cctcctaccc cagtccctaa aagaaatggg     1440

gaaaaaagaa aacaacagca agtcagaaaa aaaaaacaag agagagaaat tcatattatt     1500

attattatta taatacaata ttttttttaa aagactgctg catccttagg aaggatcaga     1560

aaccatgctg cccgtaagag tcacaacctg tgtgtgcgcg caaggttagc aacaaacgta     1620

cccgcttggc aagcccaccc ttcctgtggc ctctgtgcac gcaccttcca gtgaacagag     1680

actcttcacc ttcgacccat ccattgtccc agctgggaag gggacattcc cactagttct     1740

cattcattct tgcttttatg aaaaataaaa gtgaaaaacc tccatcaacc agctacttgc     1800

agcatctcct gaggacttgc ttctcctgcc tctggggaag agagggaaga gaaagcacag     1860

agcagagaag cagagatgtt ccttgaactg cccacaagtt ttcaataact tttatttctg     1920

ttttgtaatg accaaaggaa tgaggctgac ataggtatat atatatattt ttttccttta     1980

tttgataaag agccaattct ttaaacccat gagtttatgc cctgggctcc ttagcccaca     2040

atagtgtaat aaaagtgccc cgggctggtt tgtgcttatt tctgccattg tccctctcac     2100

gttcccagag aggtcattct ttttggtcca actcttgctg tcctttctta ccacctgtgc     2160

accccacttg gagcagtggg aggaaatctg ggtttgtggc cccacaaagg ctgtatatgt     2220

aaagatacac ctatgtatgt ggtggaactc acctttacac acaactgcag cttttccttg     2280

gagtctgtac caggtggtgg ttatggggtc tgaaccaaag gatagcagct cttcattcct     2340

cttctgacat gtgcatgctg ctccccccag ccctgggctt tcctgaattg ccaagcctgg     2400

tgcctttcca aaggactagc agggcctgtg gtggagccag cagaaccaca ggagagtgcc     2460

ctgcctgtct cagtggaagt gtattattgt tttaaggata gaaccagagg ccttgaaggg     2520

agccaagaca gaactcccag cctgtgtaat ctattggaag gcacattttc atttctgatg     2580

cagccacctt ctggaggcag cttttatcct ttctctctat tgctatgttg aagtaatagg     2640

gtttttttta acctctggat gtctcgtctg tggttgagtt tatggtaatg ggtacatggg     2700

tcaggccatg tattaacaga tgccagtgcg ctctgacaag tattccaaag tgttctgtag     2760

ctagactggt gcaggctcgt tgtaccactg caaccgactg acgttactgt agttcctaga     2820

atgctgtgag ggcggggggt tcagatcaac ataaagccta acttgctgga gttgtagtct     2880

caaggctttc tctcttgctt aactaaaacc taaggaccac tgtttttggt agcaattata     2940

tggttactat ccactgcagt cctcagttgt tggggtaaat cccacatggc agagtaaggc     3000

accccacaga aattaacttg gagagcctga gaaattccca gtggccttgg catagctgtc     3060

tagaacacca tctctaggaa aatttaattc tgtccctggc cagctattgt tcttccactt     3120

cgttttctgc tgtcccaagg ccagatgagt ggaatcacca tctgactgct gtcaataaaa     3180

tgtatctggc gtgaacagca ggataaccca tgttctccac ataaggataa ccttacgtga     3240

aaccttcctg ctgacaacca tgcagaggaa tttttccact taagtcagag ccttcctccc     3300

catctggaat tcacagctgt tccctggcag cacacaggag ggtattaagg acctttgtga     3360

ggctaggtac actgtccaca cctctttggg gaagttacga tttttttttt ccatcataat     3420

tcagtctctt cttattctac agtgtgcact ttatgcctct cgccttttga taatagttgt     3480

tcagtgaagg aagtcagctg ccagaatatt aagaagggtc tccctttatg tcagtacaac     3540

tgttagggcg gccttcccat ttactttagg tttcaagagg attcaccgga agcacatgcc     3600

ccggtctagt cccatttgaa acagttctgc tttactgaga ccctaggccg gtctccttgc     3660

tgaccctagc gctgctgcct aggtgccatt tcctttcctc ctcagtcaaa tacaggctgc     3720

acattttgtc acttaatgcc agtacaatct gtgttactcc taaggacttt tgggattttg     3780

atgagacctg cgagggagaa gacactgaga agccagtgat ctgcaagcat ttgctcttgt     3840

ttccacatca cctctgggat atttcagctg ttgtttccaa atggcaaatc atcaactaaa     3900

agcacttgtt tcaagttttg ttctgcactc ccacgactga agttgtagat tgagctgaat     3960

aaccatggga agtgaccaag caaagacact cgattggagt cagttgaata tttgtaccct     4020

cagtggagcc cttctggtct tttcttccac ttctgcagaa tttcctctag caaatacttc     4080

tttctccttg cttgcctcca ccatgatatt tgaataagag atggccagag gataacactt     4140

gtctcttaaa aactaagcta aaaagaacct agaaccttca attgagcagt tgtgaaaatt     4200

gctaatggtg ccaaggccaa gcaaagagtt tcagaaaatg actgagaagg agcgataacc     4260

cccagaatgc aaaatcaggg gcatcattat ccggtgcttg aacaaggagc tccgctctac     4320

aactggtttt tttaggactt gtgaggaaca cagcaacgga aatccatcca caaaggatgc     4380

agtgccccaa cttgtactgc gcctgaatag tcatgtgata atttactgaa gaaatctagt     4440

gtactttaaa tttttttcat aaaagtttac attgtattgt aggttaacat taaatgtttt     4500

atagcaaaaa cttca                                                      4515


<210> 393
<211> 3893
<212> DNA
<213> Homo sapiens

<400> 393
tgtgggaagc gcccgcgctt tcggcgggtt ccgttaaaat ggcgccctgg tggccggcgg       60

cgcccgcgcc ttagcctgtc aggagcaggg agcttgcggg gcgcaggaag ggcgcgggcc      120

gcggtccctg cgcgtgcggc ggcagtggcg gctctgcccg gaccaccgtg cacggctccg      180

ggcgaggatg gcgaccccgg accagaagtc gccgaacgtt ctgctgcaga acctgtgctg      240

caggatcctg ggcaggagcg aagctgatgt agcccagcag ttccagtatg ctgtgcgggt      300

gattggcagc aacttcgccc caactgttga aagagatgaa tttttagtag ctgaaaaaat      360

caagaaagag cttattcgac aacgaagaga agcagatgct gcattatttt cagaactcca      420

cagaaaactt cattcacagg gagttttgaa aaataaatgg tcaatactct acctcttgct      480

gagcctcagt gaggacccac gcaggcagcc aagcaaggtt tctagctatg ctacgttatt      540

tgctcaggcc ttaccaagag atgcccactc aaccccttac tactatgcca ggcctcagac      600

ccttcccctg agctaccaag atcggagtgc ccagtcagcc cagagctccg gcagcgtggg      660

cagcagtggc atcagcagca ttggcctgtg tgccctcagt ggccccgcgc ctgcgccaca      720

atctctcctc ccaggacagt ctaatcaagc tccaggagta ggagattgcc ttcgacagca      780

gttggggtca cgactcgcat ggactttaac tgcaaatcag ccttcttcac aagccactac      840

ctcaaaaggt gtccccagtg ctgtgtctcg caacatgaca aggtccagga gagaagggga      900

tacgggtggt actatggaaa ttacagaagc agctctggta agggacattt tgtacgtctt      960

tcagggcata gatggcaaaa acatcaaaat gaacaacact gaaaattgtt acaaagtaga     1020

aggaaaggca aatctaagta ggtctttgag agacacagca gtcaggcttt ctgagttggg     1080

atggttgcat aataaaatca gaagatacac ggaccagagg agcctggacc gctcattcgg     1140

actcgtcggg cagagctttt gtgctgcctt gcaccaggaa ctcagagaat actatcgatt     1200

gctctctgtt ttacattctc agctacaact agaggatgac cagggtgtga atttgggact     1260

tgagagtagt ttaacacttc ggcgcctcct ggtttggacc tatgatccca aaatacgact     1320

gaagaccctt gcggccctag tggaccactg ccaaggaagg aaaggaggtg agctggcctc     1380

agctgtccac gcctacacaa aaacaggaga cccgtacatg cggtctctgg tgcagcacat     1440

cctcagcctc gtgtctcatc ctgttttgag cttcctgtac cgctggatat atgatgggga     1500

gcttgaggac acttaccacg aattttttgt agcatcagat ccaacagtta aaacagatcg     1560

actgtggcac gacaagtata ctttgaggaa atcgatgatt ccttcgttta tgacgatgga     1620

tcagtctagg aaggtccttt tgataggaaa atcaataaat ttcttgcacc aagtttgtca     1680

tgatcagact cccactacaa agatgatagc tgtgaccaag tctgcagagt caccccagga     1740

cgctgcagac ctattcacag acttggaaaa tgcatttcag gggaagattg atgctgctta     1800

ttttgagacc agcaaatacc tgttggatgt tctcaataaa aagtacagct tgctggacca     1860

catgcaggca atgaggcggt acctgcttct tggtcaagga gactttataa ggcacttaat     1920

ggacttgcta aaaccagaac ttgtccgtcc agctacgact ttgtatcagc ataacttgac     1980

tggaattcta gaaaccgctg tcagagccac caacgcacag tttgacagtc ctgagatcct     2040

gcgaaggctg gacgtgcggc tgctggaggt ctctccaggt gacactggat gggatgtctt     2100

cagcctcgat tatcatgttg acggaccaat tgcaactgtg tttactcgag aatgtatgag     2160

ccactaccta agagtattta acttcctctg gagggcgaag cggatggaat acatcctcac     2220

tgacatacgg aagggacaca tgtgcaatgc aaagctcctg agaaacatgc cagagttctc     2280

cggggtgctg caccagtgtc acattttggc ctctgagatg gtccatttca ttcatcagat     2340

gcagtattac atcacatttg aggtgcttga atgttcttgg gatgagcttt ggaacaaagt     2400

ccagcaggcc caggatttgg atcacatcat tgctgcacac gaggtgttct tagacaccat     2460

catctcccgc tgcctgctgg acagtgactc cagggcactt ttaaatcaac ttagagctgt     2520

gtttgatcaa attattgaac ttcagaatgc tcaagatgca atatacagag ctgctctgga     2580

agaattgcag agacgattac agtttgaaga gaaaaagaaa cagcgtgaaa ttgagggcca     2640

gtggggagtg acggcagcag aggaagagga ggaaaataag aggattggag aatttaaaga     2700

atctatacca aaaatgtgct cacagttgcg aatattgacc catttctacc agggtatcgt     2760

gcagcagttt ttggtgttac tgacgaccag ctctgacgag agtcttcggt ttcttagctt     2820

caggctggac ttcaacgagc attacaaagc cagggagccc aggctccgtg tgtctctggg     2880

taccaggggg cggcgcagct cccacacgtg aagctcgcgg tcctcccagg gagctgcggg     2940

tgatgttcgt tgcactgcta gacacgaaat tcccattgac gtcctgcagg aactgcatgc     3000

tgcaggtgtc ctgcccttcc gcccacgagt gcgccatgtt tcagcggagc ggcgtgtggg     3060

agaagccacg tcgtgtttca catgtcggag tcgaatgcat ttgtaaatcc ctaagtcaag     3120

taggctggct gcactgttca catttgtctc taaaagtctt catcgctaaa agataccata     3180

atttgctgag gcttcttaag ctttctatgt tataatttat atttgtcact ttaaaaaatc     3240

catttctttt agaaaaaatt agggtgatag gatattcatt agttaagatg gtaacgtcat     3300

tgctattttt ttaacatcct ctttagaggt aatttttgtt aacataacca aaaattaaat     3360

tgaaacaaaa tgtcccaact aagaaaatat atagagcatt ttattttttt ttagtgttgt     3420

aaaatattaa cctctgtgag atcctttgta tcttaatgca ttacctttac acatatttat     3480

tcttattttc tctcctttca gagtttacat ttttatattt aatttactat ttcagatttt     3540

taaaatagta tagaaaaaag taggagtgat agagaacaaa aatactctta tacagtgcaa     3600

cccaaatacc gcgaatgcat cagctaaagc agcgtgtaaa taggagtgac gagaaagtta     3660

atggagtatt ttattttcaa agttcctgat aagcattgga aagaaatcga catggataat     3720

gaagatttcc tttttccttg cctatttttt cattgtaaat atttatatac tactgaccaa     3780

gatgttgggg tgggggggat tgttttttgt aaaaatgtca ttatcaggtc acataaatct     3840

gcctttatgt tgcataagtg aaaatttaga aaattaaaag caattatctt tca            3893


<210> 394
<211> 2995
<212> DNA
<213> Homo sapiens

<400> 394
cctgggacca acttcgcgaa gcgggaagcc cggcgggggg gtggggggag ctaaagacct       60

gcggcctcag cccctccaaa gaacagggag atgacgggga aagcagggga agcgctgagc      120

aagcccaaat ccgagacagt ggccaagagt acctcggggg gcgccccggc caggtgcact      180

gggttcggca tccaggagat cctgggcttg aacaaggagc ccccgagctc ccacccgcgg      240

gcagcgctcg acggcctggc ccccgggcac ttgctggcgg cgcgctcagt gctcagcccc      300

gcgggggtgg gcggcatggg gcttctgggg cccggggggc tccctggctt ctacacgcag      360

cccaccttcc tggaagtgct gtccgacccg cagagcgtcc acttgcagcc attgggcaga      420

gcatcggggc cgctggacac cagccagacg gccagctcgg attctgaaga tgtttcctcc      480

agcgatcgaa aaatgtccaa atctgcttta aaccagacca agaaacggaa gaagcggcga      540

cacaggacaa tctttacctc ctaccagcta gaggagctgg agaaggcatt caacgaagcc      600

cactacccag acgtctatgc ccgggagatg ctggccatga aaacggagct gccggaagac      660

aggatacagg tctggttcca gaaccgtcga gccaagtgga ggaagcggga gaagtgctgg      720

ggccggagca gtgtcatggc ggagtatggg ctctacgggg ccatggtgcg gcactccatc      780

cccctgcccg agtccatcct caagtcagcc aaggatggca tcatggactc ctgtgccccg      840

tggctactgg ggatgcacaa aaagtcgctg gaggcagcag ccgagtcggg gaggaagccc      900

gagggggaac gccaggccct gcccaagctc gacaagatgg agcaggacga gcggggcccc      960

gacgctcagg cggccatctc ccaggaggaa ctgagggaga acagcattgc ggtgctccgg     1020

gccaaagctc aggagcacag caccaaagtg ctggggactg tgtctgggcc ggacagcctg     1080

gcccggagta ccgagaagcc agaggaggag gaggccatgg atgaagacag gccggcggag     1140

aggctcagtc caccgcagct ggaggacatg gcttaggtca aggcgcgctc agatgccgga     1200

gccccaagac tctgctctcc tcgggccctg tggtgctggg agatgctctc tgaggcaagg     1260

cccagacctg gcctctgcca tcctccctgt tccccacagg tcctccatca cccctggtgg     1320

ctgcaggcac cgctgggttc tgactctgga ccatgctgag acatccctca tctagtcttg     1380

acctctccag catcccagcc tcagaagcct tcttgctgcc cacaacgtcc cctcaagccc     1440

cttctctcaa tccctttgca acgctcactg gttttggcca ccccttgctc tctgttctct     1500

tgctttaaag agtcctcctt cccagctcta cattctgctc tgcccatgcc taaagcccat     1560

tgctgcaaat gcattgtgaa ttgcctgcca tggctgtgac acagacggag gactggaact     1620

gcaactccag cgtcctcagc accccactcc tcagtaaaag tcttctccca actcagcctg     1680

ttccttcctg cagacctggc tgggcctggg cttccacagt gtgaagacac tgtgcaggcc     1740

caggcaggcc cagcctctgc cccacccatc agtggagtcc agatggcagg ctacagttgg     1800

gaagtctcag cctgggcccc tcagccaccc ttggtctcat gccccgccat ggtcaccctc     1860

aggaacccac cctctccaca cccagcctgt cccactggct cctcccagca caggcaccta     1920

tgtggcatgt ggtgatgtac gctgcgtgcc atgagtccat gtcctatgcc tcacaaatgc     1980

tgtggttcac tgcactgttc aggagtccaa accttctacc ctgggtcctc gggcccctga     2040

gcctgtgtcc tgaagaatct cgactctcgt gatatgctgc ttgtgacctt gacttgccat     2100

gaaggcacct gcccccacag ctccttgcaa actatgagtt cacatgtgcc ctgccttgaa     2160

caacccaatc tggctggtaa atgacatcta cgaagccaca ggcctggcct caactgagaa     2220

gccaagcctg gagtaggcct ggggctatgc atacgcatta agggcctgct ggagaaacct     2280

tcactccaga cagacagggg gctaaggggc tagggctgag cacctctcag agcaagcctt     2340

tgacctgttc agaaggatgg gaaaaaggct ggaaggaaag caaggcagaa ggccaggagt     2400

aagcccaagc taagctgcag gcacacacgc cttcatgcca gtgcatgcca ggaagcacgt     2460

tcactagact aaaacacggt aaccatgatg gaataaggag ctggggcttc tttctgctgg     2520

ctgatgggtg gacctgtgta tggtgacctc tccggcctgg ccttttccat tcgcatgaac     2580

aatgggagca catagccctg ttgacctgcc cgatccagat tcccaggcca ggctcccgac     2640

cccatccacc tatccaccac cccacccacc tttgcaggga atacctcgtt agagaatggc     2700

ctgagacagt gcgttgcaac tttttaattc catatcaaaa gttgatttct tcttcattcc     2760

atttatggaa cttccctccc cctagtccgg ttcttcttgt ctttgtccct gttggtttga     2820

agtgttagac tatagcccct ggtgtgtaaa taatgtacat agagtgagaa gaaagaaact     2880

tgatattgag gtgtttgaaa tatggaactg taataacttc taggtattcg aaacctgtga     2940

tttctgtgcc attttctgta aagatacaag taagaataaa attgacttaa aaata          2995


<210> 395
<211> 3264
<212> DNA
<213> Homo sapiens

<400> 395
aaaccagcag ccacccctaa tgcagccggc cccctcctaa gggatcatgg gccttgaagt       60

cctttgctgg ccacaccctc gttttctgtc ataggagtga gaactacgcc tcccaggatg      120

ccgcggtgag gccgccgtca cggacgccct cttccccgcc ctccttgcgc gcagccttct      180

gggatgtata gtcctagatc cgagcacgca gcggcaaaag ggcgcagaag aaccacaaac      240

cccagaagcc ctcgcgccca ctcttctccc tcccctccag aagtcggagt gctgtttttg      300

ttgttggtga aaggtgaggg gaacagctga tccgtctgtt gggaggacag atatctcaag      360

gccaggatgg aagaatcacc actaagccgg gcaccatccc gtggtggagt caactttctc      420

aatgtagccc ggacctacat ccccaacacc aaggtggaat gtcactacac ccttccccca      480

ggcaccatgc ccagtgccag tgactggatt ggcatcttca aggtggaggc tgcctgtgtt      540

cgggattacc acacatttgt gtggtcttcc gtgcctgaaa gtacaactga tggttccccc      600

attcacacca gtgtccagtt ccaagccagc tacctgccca aaccaggagc tcagctctac      660

cagttccgat atgtgaaccg ccagggccag gtgtgtgggc agagcccccc tttccagttc      720

cgagagccaa ggcccatgga tgaactggtg accctggagg aggctgatgg gggctctgac      780

atcctgctgg ttgtccccaa ggcaactgtg ttacagaacc agctcgatga gagccagcaa      840

gaacggaatg acctgatgca gctgaagcta cagctggagg gacaggtgac agagctgagg      900

agccgagtgc aggagctcga gagggctctg gcaactgcca ggcaggagca cacggagctg      960

atggaacagt acaaggggat ttcccggtcc catggggaga tcacagaaga gagggacatc     1020

ctgagccggc aacagggaga ccatgtggca cgcatcctgg agctagagga tgacatccag     1080

accatcagtg agaaagtgct gacgaaggaa gtggagctgg acaggcttag agacacagtg     1140

aaggccctga ctcgggaaca agagaagctc cttgggcaac tgaaagaagt acaagcagac     1200

aaggagcaaa gtgaggctga gctccaagtg gcacaacagg agaaccatca cttaaatttg     1260

gacctgaagg aggcgaagag ctggcaagag gagcagagtg ctcaggctca gcgactgaaa     1320

gacaaggtgg cccagatgaa ggacacccta ggccaggccc agcagcgggt ggccgagctg     1380

gagcccttga aggagcagct tcgaggggcc caggagcttg cagcctcaag ccagcagaaa     1440

gccacccttc ttggggagga gttggccagt gcagcagcag ccagggaccg caccatagcc     1500

gaactacacc gcagccgcct ggaagtggct gaagttaacg gcaggctggc tgagctcggt     1560

ttgcacttga aggaagaaaa atgccaatgg agcaaggagc gggcagggct gctgcagagt     1620

gtggaggcag agaaggacaa gatcctgaag ctgagtgcag agatacttcg attggagaag     1680

gcagttcagg aggagaggac ccaaaaccaa gtgttcaaga ctgagctggc ccgggagaag     1740

gattctagcc tggtacagtt gtcagaaagt aagcgggagc tgacagagct gcggtcagcc     1800

ctgcgtgtgc tccagaagga aaaggagcag ttacaggagg agaaacagga attgctagag     1860

tacatgagaa agctagaggc ccgcctggag aaggtggcag atgagaagtg gaatgaggat     1920

gccaccacag aggatgagga ggccgctgtg gggctgagct gcccggcagc tctgacagac     1980

tcagaggacg agtccccaga agacatgagg ctcccaccct atggcctttg tgagcgtgga     2040

gacccaggct cctctcctgc tgggcctcga gaggcttctc cccttgttgt catcagccag     2100

ccggctccca tttctcctca cctctctggg ccagctgagg acagtagctc tgactcggct     2160

gaagatgaga agtcagtcct gatggcagct gtgcagagtg ggggtgagga ggccaactta     2220

ctgcttcctg aactgggcag tgccttctat gacatggcca gtggctttac agtgggtacc     2280

ctgtcagaaa ccagcactgg gggccctgcc acccccacat ggaaggagtg tcctatctgt     2340

aaggagcgct ttcctgctga gagtgacaag gatgccctgg aggaccacat ggatggacac     2400

ttctttttca gcacccagga ccccttcacc tttgagtgat cttactccct cgtacatgca     2460

caaatacaca ctcatgcaca cacacactca cacacatgca tacacttagg tttcatgccc     2520

attttctatc acactgggct ccatgatatt ctgttcccta agaactgctt ctgtgtgccc     2580

tgttttcatc ccaagatttc tcacttcatc ctctcctacc tggctctttt gtcccaggga     2640

ggggtcctgt tcggaagcag tggctgaatt tatcccctga aagtggtttt ggaggaaccg     2700

ggatggagga ggccttcccc tgtgggaata gaatcgtcca ctcctagccc tggttgcttc     2760

tgatacacag ccactgcaca cacacactca cactcacact cccttgtctg atgccccaaa     2820

gccaattcct ggggcaccct accctctctt atttggagtt tccgttggtt tacctgagtt     2880

ttctctgggg tctgcacaga ggcagcagca tggacatcat ggcctctcag gtcccttttg     2940

gttctcagtt tcattggttc ctctttctgt tcccccattg acttctgtgc cccaccctag     3000

ccttttccat aaccttaggt attcagtttg gaggggtttt ttgtattttt gaggattcct     3060

gtattctgta tcctctcctc gcatctcctc acatggaaag aaataatgta tttgtgcctt     3120

ctgtgaggaa tggggggaac aagtggtccc aggtatcccc atttccaagg cccccctccc     3180

tctccaggtc cccccacagc aataaaagct tccccctgat atccatccct ttgtagtttg     3240

aacaaatata tttatatgat atgt                                            3264


<210> 396
<211> 2939
<212> DNA
<213> Homo sapiens

<400> 396
gtttgtccgc cactgtttga aaacagttgg cgccgccgcc gccggggcct catttccagg       60

tcagcccccg gcctgacgcg gcgttgcgtc ccccgggagc tgcgctaggc gaacggctgc      120

ggcgctttgt gctccagtcg ctcctaacgc tccctggccc ggccggggcc gcgcagttag      180

ggcatctgag gcggggagaa gcggcgggga gacgccggct gccagcatgt cgctgcctcc      240

ggagaaagcc tccgagctga agcagctcat ccaccagcag ctgagcaaga tggatgtcca      300

tggtagaata agagaaatcc ttgctgagac tatacgggaa gaattggcac ctgatcaaca      360

gcatttatca acagaagatt tgatcaaagc ccttagacgt cgaggaatca ttgacgatgt      420

gatgaaagaa cttaattttg ttactgacag tgttgagcaa gaactccctt cctctccaaa      480

acaacctatt tgttttgata gacaatcgac attaaaaaaa actaatattg atccaacacg      540

gaggtatctt taccttcagg ttttgggtgg aaaagctttc ttggaacatc tgcaagaacc      600

tgagccttta cctggacaag tttgttcaac gtttacttta tgtttacatt atcgaaacca      660

acgttttcgt tctaaacctg ttccatgtgc ctgtgaacca gattttcatg atggcttttt      720

acttgaagta cacagagaaa gcttgggtga tggaactaga atggctgatt caacaacaat      780

gttatcaata agtgatccaa ttcatatggt gctaatcaaa acagacatat ttggtgagac      840

gactttagta gcatcatatt ttctggaatg gcgatcggtt ttgggctcag aaaatggagt      900

gaccagtctg actgtggaac ttatgggtgt aggcacagaa tcaaaagttt ctgtgggaat      960

tttaaatata aaacttgaaa tgtatccacc actcaatcaa acgttatctc aagaagtagt     1020

gaacacacag cttgctttgg aacgtcagaa aactgcagag aaagagcgat tatttcttgt     1080

atatgctaag cagtggtgga gagaatattt gcaaattcga ccctcacaca actcacgact     1140

ggttaagatt tttgcacagg atgaaaatgg gataaataga ccagtctgtt cctatgttaa     1200

accacttcga gctggacggc ttcttgatac tccaaggcaa gcagcaagat ttgttaatgt     1260

ccttggttat gaacgagccc ctgttattgg aggaggaggt aaacaggagc agtggtgcac     1320

tctgctggcc tttctctgta gaaacaaggg tgactgtgaa gatcacgcta accttctgtg     1380

cagccttctt cttggatatg gattagaagc ctttgtttgt gttgggacca aggcaaaagg     1440

agtacctcat gcatgggtta tgacttgtgg aactgatggg gccatcactt tttgggagag     1500

tttaacagga cacaggtaca tccataaacc taccaatcct gatgaacctc cagttgctga     1560

acagcccaaa ccactgtacc catatcgaac aattggttgt gttttcaacc atcagatgtt     1620

cctgggaaat tgtcaaccct ctgatgcagt agaaacctgt gtatttgatt tgaacgatga     1680

atccaaatgg aaacccatga gtgaggaagc aattaaatct gtgtgtgctc ctggagctac     1740

aacatccctt cctccctttc cacctctgtg tgcatccaca attgacgcgt cagtaacaag     1800

taatgaaatt gaaatgcagc tgaggctcct ggtgtcagaa cacaggaagg atcttggcct     1860

cactactgtt tgggaagacc agctctccta ccttttatca ccagctttgg cttcttatga     1920

atttgagcgt acaacaagta tatcagcagg caatgaagaa tttcaagatg ccataagaag     1980

ggctgtacct gatggtcaca catttaaagg gttcccaata cattttgtgt atagaaatgc     2040

aagacgtgca tttgccacat gtcttcgatc tcctttctgt gaagaaataa tctgttgccg     2100

tggagaccaa gtgcgactgg cagttcgtgt ccgagtattt acttaccctg aatctgcatg     2160

tgctgtttgg atcatgtttg cttgtaaata tcgctcggta ttatagggcc aatatttata     2220

taagatttat acctgtgttt aattggaatt ttacacattg tacattactt agctatttag     2280

aggtttgtta ttttaaaatc acaatctggc ttgaatggca tacttcaatt ttgtatatac     2340

ttgactggta atgtttaaaa aaaatcatgc attcctttaa aaattaaggc tgaaaaactt     2400

gtataaatct ccctggaatt tagtataaat taagtgtata ttctatttta ataaatgcta     2460

ctttgtttac agttatcagt agtttaaata ttaatataaa atgcattcag ttttctttac     2520

acaaacaggt aatcaaagag atgtttgtct aagggtttga gccctagaca aatcagtatg     2580

atcattactt ttcacaggtt aatggaatta ttttatacag attaggagaa attaacctca     2640

tgacagattt atttattgca ttggtgaaaa taaatgttaa tgaattacca cttttgtggt     2700

ttattcgtgg tccttgggat atttgagact gtccagaaat ttatggttgg accttgaagc     2760

aagagtagga aaaaactaat accagaaaag cataaatatt aataacctca tatgaaagta     2820

catgaatcat ttagaaatat ttatcactgt gatttgttgt aaaaatgaat tgggtatttt     2880

agaaaaactt tattatacct ctttgttatg atactgataa attgtgatct tgcagtcga      2939


<210> 397
<211> 2136
<212> DNA
<213> Homo sapiens

<400> 397
ctggggaggg ggaggagcct cgaggccggt ttggaatttt tggcgcgagc agctccgcgc       60

gcgttcacgg gccgttcccc ctcacgggag tcctccgccc gggcgtccgg aacagtcgac      120

ggcagactcc ggcccgctga gccacccgag gggtcccgtg gcctccgcgg acccggaatc      180

tgggccctcg cggacccgcg ccccgcccag tcgccccagg gcttccccac acccacggag      240

tgaagtcagc cgcggccctg cctgggagga acttaccgtc taccgggaaa ggtggccagc      300

agatgtgtcg ggcctggtga gagggtgagg cgagacggcc cgatcgccca gggccccgga      360

agctgcggag gtcacccccg cctggcctta gctcagggac accctggatt cacgtgggag      420

cccctgctcc tgcctccccc gtcccaccac tgaggctgtt gggccaggcc agtcatgcta      480

gaacggcctc ctgcactggc catgcccatg cccacggagg gcaccccgcc acctctgagt      540

ggcaccccca tcccagtccc agcctacttc cgccacgcag aacctggatt ctccctcaag      600

aggcccaggg ggctcagccg gagcctccca cctccgcccc ctgccaaggg cagcattccc      660

atcagccgcc tcttccctcc tcggacccca ggctggcacc agctgcagcc ccggcgggtg      720

tcattccggg gcgaggcctc agagactctg cagagccctg ggtatgaccc aagccggcca      780

gagtccttct tccagcagag cttccagagg ctcagccgcc tgggccatgg ctcctacgga      840

gaggtcttca aggtgcgctc caaggaggac ggccggctct atgcggtaaa gcgttccatg      900

tcaccattcc ggggccccaa ggaccgggcc cgcaagttgg ccgaggtggg cagccacgag      960

aaggtggggc agcacccatg ctgcgtgcgg ctggagcagg cctgggagga gggcggcatc     1020

ctgtacctgc agacggagct gtgcgggccc agcctgcagc aacactgtga ggcctggggt     1080

gccagcctgc ctgaggccca ggtctggggc tacctgcggg acacgctgct tgccctggcc     1140

catctgcaca gccagggcct ggtgcacctt gatgtcaagc ctgccaacat cttcctgggg     1200

ccccggggcc gctgcaagct gggtgacttc ggactgctgg tggagctggg tacagcagga     1260

gctggtgagg tccaggaggg agacccccgc tacatggccc ccgagctgct gcagggctcc     1320

tatgggacag cagcggatgt gttcagtctg ggcctcacca tcctggaagt ggcatgcaac     1380

atggagctgc cccacggtgg ggagggctgg cagcagctgc gccagggcta cctgccccct     1440

gagttcactg ccggtctgtc ttccgagctg cgttctgtcc ttgtcatgat gctggagcca     1500

gaccccaagc tgcgggccac ggccgaggcc ctgctggcac tgcctgtgtt gaggcagccg     1560

cgggcctggg gtgtgctgtg gtgcatggca gcggaggccc tgagccgagg gtgggccctg     1620

tggcaggccc tgcttgccct gctctgctgg ctctggcatg ggctggctca ccctgccagc     1680

tggctacagc ccctgggccc gccagccacc ccgcctggct caccaccctg cagtttgctc     1740

ctggacagca gcctctccag caactgggat gacgacagcc tagggccttc actctcccct     1800

gaggctgtcc tggcccggac tgtggggagc acctccaccc cccggagcag gtgcacaccc     1860

agggatgccc tggacctaag tgacatcaac tcagagcctc ctcggggctc cttcccctcc     1920

tttgagcctc ggaacctcct cagcctgttt gaggacaccc tagacccaac ctgagcccca     1980

gactctgcct ctgcactttt aaccttttat cctgtgtctc tcccgtcgcc cttgaaagct     2040

ggggcccctc gggaactccc atggtcttct ctgcctggcc gtgtctaata aaaagtattt     2100

gaaccttggg agcacccaag cttgctcatg tggcaa                               2136


<210> 398
<211> 582
<212> DNA
<213> Homo sapiens

<400> 398
gctgcgccgg cgcgtcgagg ggagaggcag cagccgcgat ggacgtgttc ctcatgatcc       60

ggcgccacaa gaccaccatc ttcacggacg ccaaggagtc cagcacggtg ttcgaactga      120

agcgcatcgt cgagggcatc ctcaagcggc ctcctgacga gcagcggctg tacaaggatg      180

accaactctt ggatgatggc aagacactgg gcgagtgtgg cttcaccagt caaacagcac      240

ggccacaggc cccagccaca gtggggctgg ccttccgggc agatgacacc tttgaggccc      300

tgtgcatcga gccgttttcc agcccgccag agctgcccga tgtgatgaag ccccaggact      360

cgggaagcag tgccaatgaa caagccgtgc acctgcatgt ccactcccag acgatggcca      420

agagcagaaa cacaagctgg agccagtgtc ctggtttgac agcatgttca acgagggaac      480

cccaagacgg acccacacag gtccacccac gctgggggct gtaatcacgg agggaagtgg      540

ctgccccctt aacacacctt taataaacag tctacagacc ca                         582


<210> 399
<211> 3327
<212> DNA
<213> Homo sapiens

<400> 399
ctctcgcgag aggagcaaga ggaagatggc cgtgccctgt ttttcggtgt aaggcagcga       60

cggcggctgc gacggcgaga ctgagatcct ggtgtcgtgg gcacctgagt tctagcttcc      120

cccagcgagc gcgcgtccct tcgtgcctag gcgagagccg gctcttcccc gggagatgcg      180

tttgtcccag gctcgggggc tcagtgggag ttcatgctgc gctggaggct cttggccacc      240

gctctaatcg ccttgtgccg ccgcagcgcc agctccgtcg ccagcggtga gcctcccgat      300

tccccccctt gcccctggcg gcggcgatga ccggggagaa gatccgctca ctgcggaggg      360

accacaagcc cagcaaagaa gaaggggacc tgctggagcc cggggatgag gaagcggcgg      420

ctgccctcgg cggtaccttt accagaagca ggattggcaa gggcggcaaa gcttgtcata      480

agatcttcag taaccatcac caccggctac agctgaaggc agctccggcc tcctccaatc      540

cccccggcgc cccggctctg ccgctgcaca attcctccgt gactgccaac tcccagtccc      600

cggcccttct ggccggcacc aaccccgttg ctgtcgtcgc ggatggaggc agttgccccg      660

cacactaccc ggtgcacgag tgcgtcttca agggggatgt gaggagactc tcctctctca      720

tccgcacgca caatatcggg cagaaagata atcacggaaa tactccttta caccttgctg      780

tgatgttagg aaataaagtt acagctcttt tgaggaagct taagcagcaa tccagggaaa      840

gtgttgaaga aaaacgacct cgattattaa aagccctgaa agagctaggt gacttttatc      900

tagaacttca ctgggatttt caaagctggg tgcctttact ttcccgaatt ctgccttccg      960

atgcatgtaa aatatacaaa caaggtatca atatcaggct tgacacaact ctcatagact     1020

ttactgacat gaagtgccaa cgaggggatc taagcttcat tttcaatggg gatgcggcgc     1080

cctctgaatc ttttgtagta ttagacaatg aacaaaaagt ttatcagcga atacatcatg     1140

aggaatcaga gatggaaaca gaagaagagg tggatatttt aatgagcagt gatatttact     1200

ctgcaacttt atcaacaaaa tcaatttctt tcacgcgtgc ccagacagga tggctttttc     1260

gggaagataa aacagaaaga gtaggaaact ttttggcaga cttttacctg gtgaatggac     1320

ttgttttaga atcaaggaaa agaagagaac atctcagtga agaggatatt cttcgaaata     1380

aggccatcat ggagagtttg agtaaaggtg gaaacataat ggaacagaat tttgagccga     1440

ttcgaagaca gtctcttaca cctcctcctc agaacactat tacatgggaa gaatatatat     1500

ctgctgaaaa tggaaaagct cctcatctgg gtagagaatt ggtgtgcaaa gagagtaaga     1560

aaacgtttaa agctacgata gccatgagcc aggaatttcc cttagggata gagttattat     1620

tgaatgtttt agaagtagta gctcccttca agcactttaa caagcttaga gaatttgttc     1680

agatgaagct tcctccaggc tttcctgtaa aattagatat acctgtgttt cccacaatca     1740

cagccactgt gacttttcag gagtttcgat acgatgaatt tgatggctcc atctttacta     1800

tacctgatga ctacaaggaa gacccaagcc gttttcctga tctttaactg acgtggaaaa     1860

ggatgccgtc taaccaagga aagaaaatac agagacccta gaagtggatc caaatagaag     1920

ggacaaatgc tttcagtgaa gaaaagggaa ttacacattg aatcgacaca tcagtaatac     1980

gatacagtga aatgggcctc taataagaat ttcagcgagt tttctgatgt gccatttttt     2040

gtctttttaa aaatatacat attataaatg taatagtttg acacattaat gaccctaaga     2100

cctgcgtatg tgaagcagct atgagtgctg tgatttgttt ttaaaaattt ttacacttct     2160

tgttgaaata tatatgcata taaatatatc tatatctata tctatatcta aaacactcct     2220

ggaccattaa cgtaaattaa atgtcttaag agatatggag cccttttaaa cttgtcatct     2280

ttatgcaagg tgacatttat aaatattcct tcgagctttg ttttcataaa atgtaaacta     2340

tgtaacatta tgtatagttc agtaatttga atgtttgttc aatataatga actagaagga     2400

atgcaatttt ctgtagatga atgaaccaaa tggtaaccat taaacaattg catttatatg     2460

ttgcaataca tttcagaagg agcgttcact ctgcagggaa taaggtacct cctttagcac     2520

cttagtgcaa ttcattgtgg tgctatttgt ttttacctga atgtttgtta ctaatcttcc     2580

tttcatagaa cctctatttt ttttttttct aaacttgagt ttgagtcctt gttatggtca     2640

tcataaggta atggttagca tgtttaaaga tattcctctt ccaaatctca gcactttaaa     2700

aaaaaatcca aatttttaaa cttgcttcct aataagtaca catcggtctg attattttgt     2760

ttgtttttag tagaatatgg atgcattggt gtcagtttta aaaaacaata cacatatttt     2820

ggacaaccct acatatttaa tcctttcaaa ataagataaa aacattttat atgctaacag     2880

aatatatttg ttacaagtta aagtccagaa gtatacacaa gattgattac tcctattatt     2940

ttttttaaat cacaggaaaa tattgatttc attgtctcca aagtgataaa atcatgtatt     3000

actcattttt gcacttaaaa tttttcttat ttattccaag gtggtttgaa ggtccaagta     3060

tgaaaataaa ttagggggat taatgtataa cagttataaa gtatcatgtt gtattaaaga     3120

gcttacttag attgatgttt ttaaaatgta tcctgatgaa tgtctcaaga atgcatctgt     3180

caagtttttt agactgacca gtagcttaaa cttttttcag gattttaggt aatttgaaag     3240

gagtttagag acccttattg aaaatatgat ttaaaaatcc aaagcataaa ccgtaagaaa     3300

aattttaaat aaacatcttt aaagctg                                         3327


<210> 400
<211> 3001
<212> DNA
<213> Homo sapiens

<400> 400
gagccatgta accctgcggc gggctccggg ctgctccgtc cttccccagc tcccgggcta       60

gcgcggcagc ggggccacga tgaagaagca gttcaatcgc atgcgccagc tggccaacca      120

gacggtgggc agggctgaaa agacagaagt tttgagtgaa gaccttcttc aggtggagaa      180

gcgtctggag ctggtgaaac aggtgtccca cagcacgcac aagaagctca ccgcatgtct      240

gcagggccag caaggggcag aggctgacaa gcgctccaaa aagttgcctt tgacaacact      300

ggctcagtgt ctgatggagg ggtcagctat cctgggagat gacacacttc ttgggaagat      360

gctgaaactc tgtggagaga cggaggacaa gctggctcag gagctgatac attttgagtt      420

gcaagtagag agagacgtga ttgagcccct gtttttgctg gcggaggtgg aaatcccaaa      480

tattcaaaag cagaggaaac acttagccaa gttggtgctg gacatggatt cctcacgaac      540

caggtggcag cagacttcca agtcttcagg tttgtccagc agcttacagc ctgcgggtgc      600

caaggctgat gccctcaggg aagaaatgga agaggctgcc aacagagtgg agatttgcag      660

ggaccagctc tcagctgata tgtacagttt tgtggccaaa gaaattgact atgcaaacta      720

ctttcaaacg ctaatagaag tgcaagctga ataccacagg aagtccctga cactattgca      780

ggctgtattg cctcagatca aagcacaaca ggaggcctgg gtagagaagc cttccttcgg      840

gaagccgctg gaggagcacc tcaccatcag cggccgggag atcgccttcc ccatcgaggc      900

gtgtgtgacc atgctgcttg agtgtgggat gcaggaggag ggactcttcc gagtagcccc      960

ctctgcctcc aaactgaaga agctgaaagc ggccctggac tgctgcgtgg tggatgtgca     1020

ggagtactcg gcagaccccc acgcaattgc aggagctttg aaatcttacc tccgagagtt     1080

gccagaacct cttatgacct ttgaactcta tgatgagtgg atccaggctt ccaatgtcca     1140

ggagcaagac aagaagcttc aggctctatg gaatgcttgt gaaaagttgc ccaaggccaa     1200

tcacaacaac atccgatact tgataaaatt tttatccaag ctgtcagaat atcaagatgt     1260

aaacaagatg actcccagta atatggcaat tgttttagga cccaacctcc tatggccaca     1320

agcagaaggg aacattacag agatgatgac cacagtgtcg ctgcaaattg ttgggatcat     1380

tgaacctatc atccagcatg cagactggtt cttccctggg gagatagagt tcaacattac     1440

tggcaattat gggagtccag tacacgtgaa ccataatgcc aactacagct caatgccctc     1500

cccagacatg gaccctgctg accggcgcca gcccgagcag gcccgccggc ccctcagcgt     1560

cgccacggat aatatgatgc tggagtttta caaaaaggat ggccttagga aaatccaaag     1620

catgggtgtg agggtcatgg acacaaactg ggtggctcga agaggctcct cggccggtcg     1680

gaaagtgtcc tgcgccccgc cctccatgca gcctcccgcc ccgcccgccg agctggctgc     1740

gcccctgcct tcgccgctgc cggagcagcc cctggacagc cccgcggccc ccgcgctctc     1800

tccatccggc ctgggcctcc agcctgggcc cgagcgcacc agcacaacaa aaagcaagga     1860

actttctcca ggctctgcac agaaaggaag tccaggctcc agccagggca cagcctgtgc     1920

agggactcaa ccaggggctc aacctggagc tcagccgggc gccagcccca gccccagcca     1980

gccgcctgca gaccagagtc ctcacaccct ccggaaagtt tcaaagaagc tggcaccgat     2040

tccacccaag gtcccctttg gccagccggg ggctatggca gaccagtccg ctggccagcc     2100

gtccccagtc agcctgtccc ccaccccgcc cagcaccccg tcaccctatg gactgagcta     2160

ccctcagggg tactccttgg cctcgggcca gctctcccca gctgcagctc ctcccctggc     2220

ctctccttct gtctttacaa gcactttgag caaatcgcgg cccactccta agccgcgaca     2280

gagacctact ctgccgcctc ctcagcctcc cacagtaaac ctctcggcct ctagtccaca     2340

gtccacggag gcccccatgc tagatggcat gtcccctggg gaaagcatgt ctacagctgt     2400

gtgacatgag tggcgcagtt ttggatacgt gtgaggggga ttttcaggat cttgtccact     2460

ttgatattcc ctcgatccac atagagctcg ggtcgacgct ccgcctgagt cccctggagc     2520

acatgcggcg acactcagta actgacaaga gggactcgga ggaggagtct gagagcaccg     2580

ccctctgaca tgacaccgcc catcctgcct cgcgtgtaca tacatcacgg gccctaggaa     2640

cgccgccagg agcagcgtcc atgagcttgc caagtgttct ctgctggctc tttcctgcca     2700

ctgccaacac gaggttggaa tttggcagaa aattgtgatc tccagtccgt gtggtgatgc     2760

tggtggtgca ggttttgttt gttcctttcg ggtggtgact tcggcctttt gtttgacctt     2820

tgccttttga ctttgtgcct cttttgatcc actttcagcc tccatgccag aaaacaccca     2880

cctctccatc caaggctggt caggaacgtc ctttgcaggg tcggggtggt gcgggagagg     2940

ctcactttgc ctggttagac ccaagggctg ctaccttttc cttggacggc tcatgtcagg     3000

t                                                                     3001


<210> 401
<211> 4854
<212> DNA
<213> Homo sapiens

<400> 401
gaagtgaggg tgtgagaggc ctctctggaa gttgtcccgg gtgttcgccg ctggagcccg       60

ggtcgagagg acgaggtgcc gctgcctgga gaatcctccg ctgccgtcgg ctcccggagc      120

ccagcccttt cctaacccaa cccaacctag cccagtccca gccgccagcg cctgtccctg      180

tcacggaccc cagcgttacc atgcatcctg ccgtcttcct atccttaccc gacctcagat      240

gctcccttct gctcctggta acttgggttt ttactcctgt aacaactgaa ataacaagtc      300

ttgatacaga gaatatagat gaaattttaa acaatgctga tgttgcttta gtaaattttt      360

atgctgactg gtgtcgtttc agtcagatgt tgcatccaat ttttgaggaa gcttccgatg      420

tcattaagga agaatttcca aatgaaaatc aagtagtgtt tgccagagtt gattgtgatc      480

agcactctga catagcccag agatacagga taagcaaata cccaaccctc aaattgtttc      540

gtaatgggat gatgatgaag agagaataca ggggtcagcg atcagtgaaa gcattggcag      600

attacatcag gcaacaaaaa agtgacccca ttcaagaaat tcgggactta gcagaaatca      660

ccactcttga tcgcagcaaa agaaatatca ttggatattt tgagcaaaag gactcggaca      720

actatagagt ttttgaacga gtagcgaata ttttgcatga tgactgtgcc tttctttctg      780

catttgggga tgtttcaaaa ccggaaagat atagtggcga caacataatc tacaaaccac      840

cagggcattc tgctccggat atggtgtact tgggagctat gacaaatttt gatgtgactt      900

acaattggat tcaagataaa tgtgttcctc ttgtccgaga aataacattt gaaaatggag      960

aggaattgac agaagaagga ctgccttttc tcatactctt tcacatgaaa gaagatacag     1020

aaagtttaga aatattccag aatgaagtag ctcggcaatt aataagtgaa aaaggtacaa     1080

taaacttttt acatgccgat tgtgacaaat ttagacatcc tcttctgcac atacagaaaa     1140

ctccagcaga ttgtcctgta atcgctattg acagctttag gcatatgtat gtgtttggag     1200

acttcaaaga tgtattaatt cctggaaaac tcaagcaatt cgtatttgac ttacattctg     1260

gaaaactgca cagagaattc catcatggac ctgacccaac tgatacagcc ccaggagagc     1320

aagcccaaga tgtagcaagc agtccacctg agagctcctt ccagaaacta gcacccagtg     1380

aatataggta tactctattg agggatcgag atgagcttta aaaacttgaa aaacagtttg     1440

taagcctttc aacagcagca tcaacctacg tggtggaaat agtaaaccta tattttcata     1500

attctatgtg tatttttatt ttgaataaac agaaagaaat tttgggtttt taattttttt     1560

ctccccgact caaaatgcat tgtcatttaa tatagtagcc tcttaaaaaa aaaaaacctg     1620

ctaggattta aaaataaaaa tcagaggcct atctccactt taaatctgtc ctgtaaaagt     1680

tttataaatc aaatgaaagg tgacattgcc agaaacttac cattaacttg cactactagg     1740

gtagggagga cttagggatg tttcctgtgt cgtatgtgct tttctttctt tcatatgatc     1800

aattctgttg gtattttcag tatctcattt ctcaaagcta aagagatata cattctggat     1860

acttgggagg ggaataaatt aaagttttca cactgtgtac tgtgttttac tgattggttg     1920

gatattgctt atgaaaattc catagtggta tttttttgga ttcttaatgt gtaacttaaa     1980

catactttga agtggaggag agtcataaga cagaacattt ggcaggaatt gtccttatga     2040

aacaagaaaa agaaaatgaa aagtattatt aagcttctgt gtttgtctaa aaatgtggca     2100

tatggatggc atttaaaact ttgaatgaat tatacctaaa tctgggacag ggaggtgaca     2160

gtggaacagg ctaccaatca gaactagatg acttttaagg ctcctcctat tatgagactt     2220

caatttccaa agagaagaac tagcagagaa attgtatttc agtaatttta agctccttct     2280

gtcttgtaga gtcttgttat agttgtataa atcaaaaaca cagaataagg aacatattta     2340

actttttttc attataaaat ggttagagga ccctaccccc tctagattcc ctgatttccc     2400

caggcctgca gcatacagta agatgggtcc ctgtgccagg cctcaatact gccagggaat     2460

aaaaccagag ggagaggacc ctcagtgtca tatcaggaag cccagtgcca gaggacagac     2520

aggttcaaaa ctggcttttc ctctgggcct gggttggtgc tataggccaa gggtcatttt     2580

atacttgggt ataaatcaat cccagtttgg gaaaagatta tttttaagct taaaaggctg     2640

acatgtgcca ttatatgtag tatgtaatat atgtaacatc ttccaattct tttaaaataa     2700

aattaatatt tataatggat atttaatgat tgttattttt aaaaaccagc ttataattcc     2760

tcgttatgca tgatttatcc aaagtttcca tagttttatt caaaataata aatgttaata     2820

aggtgataag gggtatattt aatgtattgt atcaaattgt gaataagaaa gtaggatgga     2880

gctttctaga ggttgggcct tagttctgtt atcctcattg cttttaacca ataagttaaa     2940

tgaagttaga gttatggtct tcaggttaga ttatggacca gatctgtgag ggtcagcatg     3000

gaaattcaca ttcaacaagg tagcacacag gaccaagagc agcacatgca atcaactgga     3060

ataatatagt aatcctgtaa ctgggtttga aaaaataatc aacaaaagat acaattcaag     3120

ggttaggttg cagagagctg gcttgagagt agttattatg aaaaaggcct caaggagtac     3180

gtgttcagta tgctctaaga tgataaagtg gctgttaaaa agggagttga tttgaggaag     3240

tattacttag cattcatgca tattgggctt aggctctagc cctgccacta tcattgtctt     3300

ctctggactg tgaagtcact gaggacaagg aaactaaatt taatgtctgt atcactagtg     3360

cctagaattt ctggacactt agtagtcacc atcaggcgtt tatttaatga atgagaagca     3420

aagtgacctt ggttactttt ttaccctgag gggctcagca ctcattagga cttggtgcct     3480

aattttataa aaagtcacta agctcaagtg cttggatgaa aggacagcgt ggataaaaag     3540

gtttttaaaa catggatgtt aaggctgttt tgcttggaga agacttggga ctgggacagt     3600

ctttagatat tatttgaaat gctggcactg tctatctgga tcccagggct tgaactagga     3660

tttgaggaag tcacagggaa gcagatttca gtctgacatt tattcagtgc aagttttttg     3720

gtgctgtagt atatgatgaa agatgtaaag ctgaataaag cattatttct gccctagagt     3780

tgttcacagc ctagtcaggc atatggatat gtaaacaatg actgtaacgt gttatagatg     3840

taaagacaaa ataaaggtta aagagggcat aaaggagcac tcaattgcag agatttgagg     3900

acattatttt tattttgagc tttaaaaaga tgaataggtg ttctcaggag gtagggatct     3960

ggctgagagg gaataatctg agcaaaggta tgaaacagcc taatgcatta gagaaaaaag     4020

ttcttttagt aaggcatttg gggttgggga agctagaaaa agaaatggga gctggtcaca     4080

cagggccttg tgtgccagac taaggggttt gtagtatata ttgtaggcag aagagatcca     4140

tcaacagatt gcaagcaagg aagtatgttc actttaaagt ttgagaaaga atagtgtgga     4200

agcacgtctc aaatttagac ttgttccccc tctgaaccgt gaatcagacc atttcaggta     4260

gaagtcttcc ccggtttatc tgatctactc ggggcctcag gcttctcagc tgggaagaga     4320

ggatgcaaga ccagactgaa gaacacggtt gagtccccag aaccaaaagg gggcctttct     4380

gcttcttagc cagctacctc ttcgagtttt tcaaattgtg agggggacca taaaaggatg     4440

gaaactttta gatgacattc tacaaattat ttttttcttt aaattaaaag aacctagcca     4500

ataagataga gaatgggcat ctaaggcatc tcagagctct ctgatgaagc caggttgtca     4560

aagatcattt gcaaaagaag ggaaaactgg catgacaaaa gctacagaga ggagagtgaa     4620

atatagaagt gtttgaaatg ttcaagctca caataagctt aaatttatag aaaatgctaa     4680

ggttgtcaag aaggcttttt tttttttctt ttttaaacct gagggcaaaa aggaatggat     4740

aaagtagtgt aatggattga caatcaggaa gaacagaata actcagtttt ttttctccta     4800

caaggagata tggctggacc aaaataaaat gacatgaaac tgcaaaaatg aaaa           4854


<210> 402
<211> 6822
<212> DNA
<213> Homo sapiens

<400> 402
gcagcagccg ccagttccat gcactggcgg agcagctcta ggcggcggct tctactttca       60

gtttcgtgca gagcgcggag gagccgcgag cgctgaggga gtctgcacta tggaaacaac      120

ctgtcaatcc agctcaaggc acacatagcc cagacaccca tgagaccctc tccgtgggga      180

ccctagagca cctatcatga acgaggagac caaggctggc tcctcatgga ccccgttggc      240

ctccagctcg gcaacaagaa cctgtggagc tgtcttgtga ggctgctcac caaagaccca      300

gaatggctga acgccaagat gaagttcttc ctccccaaca cggacctgga ttccaggaac      360

gagaccttgg accctgaaca gagagtcatc ctgcaactca acaagctgca tgtccagggt      420

tcggacacct ggcagtcttt cattcattgt gtgtgcatgc agctggaggt gcctctggac      480

ctggaggtgc tgctgctgag tacttttggc tatgatgatg ggttcaccag ccagctggga      540

gctgagggga aaagccaacc tgaatctcag ctccaccatg gcctgaagcg cccacatcag      600

agctgtgggt cctcaccccg ccggaagcag tgcaagaagc agcagctaga gttggccaag      660

aagtacctgc agctcctgcg gacctctgcc cagcagcgct acaggagcca aatccctggg      720

tcagggcagc cccacgcctt ccaccaggtc tatgtccctc caatcctgcg ccgggccaca      780

gcatccttag acactccgga gggggccatt atgggggacg tcaaggtgga agatggtgct      840

gacgtgagca tctcggacct cttcaacacc agggttaaca agggcccgag ggtgaccgtg      900

cttttgggga aggctggcat gggcaagacc acgctggccc accggctctg ccagaagtgg      960

gcagagggcc atctgaactg tttccaggcc ctgttccttt ttgaattccg ccagctcaac     1020

ttgatcacga ggttcctgac accgtccgag ctcctttttg atctgtacct gagccctgaa     1080

tcggaccacg acactgtctt ccagtacctg gagaagaacg ctgaccaagt cctgctgatc     1140

tttgatgggc tagatgaggc cctccagcct atgggtcctg atggcccagg cccagtcctc     1200

acccttttct cccatctctg caatgggacc ctcctgcctg gctgccgggt gatggctacc     1260

tcccgtccag ggaagctgcc tgcctgcctg cctgcagagg cagccatggt ccacatgttg     1320

ggctttgatg ggccacgggt ggaagaatat gtgaatcact tcttcagcgc ccagccatcg     1380

cgggaggggg ccctggtgga gttacagaca aatggacgtc tccgaagcct gtgtgcggtg     1440

cccgcactgt gccaagtcgc ctgtctctgc ctccaccatc tgcttcctga ccacgcccca     1500

ggccagtctg tggccctcct gcccaacatg actcagctct atatgcagat ggtgctcgcc     1560

ctcagccccc ctgggcactt gcccacctcg tccctactgg acctggggga ggtggccctg     1620

aggggcctgg agacagggaa ggttatcttc tatgcaaaag atattgctcc acccttgata     1680

gcttttgggg ccactcacag cctgctgact tccttctgcg tctgcacagg ccctgggcac     1740

cagcagacag gctatgcttt cacccacctc agcctgcagg agtttcttgc tgccctgcac     1800

ctgatggcca gccccaaggt gaacaaagac acacttaccc agtatgttac cctccattcc     1860

cgctgggtac agcggaccaa agctagactg ggcctctcag accacctccc caccttcctg     1920

gcgggcctgg catcctgcac ctgccgcccc ttccttagcc acctggcgca gggcaatgag     1980

gactgtgtgg gtgccaagca ggctgctgta gtgcaggtgt tgaagaagtt ggccacccgc     2040

aagctcacag ggccaaaggt tgtagagctg tgtcactgtg tggatgagac acaggagcct     2100

gagctggcca gtctcaccgc acaaagcctc ccctatcaac tgcccttcca caatttccca     2160

ctgacctgca ccgacctggc caccctgacc aacatcctag agcacaggga ggcccccatc     2220

cacctggatt ttgatggctg tcccctggag ccccactgcc ctgaggctct ggtaggctgt     2280

gggcagatag agaatctcag ctttaagagc aggaagtgtg gggatgcctt tgcagaagcc     2340

ctctccagga gcttgccgac aatggggagg ctgcagatgc tggggttagc aggaagtaaa     2400

atcactgccc gaggcatcag ccacctggtg aaagctttgc ctctctgtcc acagctgaaa     2460

gaagtcagtt ttcgggacaa ccagctcagt gaccaggtgg tgctgaacat tgtggaggtt     2520

ctccctcacc taccacggct ccggaagctt gacctgagca gcaacagcat ctgcgtgtca     2580

accctactct gcttggcaag ggtggcagtc acgtgtccta ccgtcaggat gcttcaggcc     2640

agggaggcgg acctcatctt ccttctttcc ccgcccacag agacaactgc agagctacaa     2700

agagctccag acctgcagga aagtgacggc cagaggaaag gggctcagag cagaagcttg     2760

acgctcaggc tgcagaagtg tcagctccag gtccacgatg cggaggccct catagccctg     2820

ctccaggaag gccctcacct ggaggaagtg gacctctcag ggaaccagct ggaagatgaa     2880

ggctgtcggc tgatggcaga ggctgcatcc cagctgcaca tcgccaggaa gctggacctc     2940

agtaacaacg ggctttctgt ggccggggtg cattgtgtgc tgagggccgt gagtgcgtgc     3000

tggaccctgg cagagctgca catcagcctg cagcacaaaa ctgtgatctt catgtttgcc     3060

caggagccag aggagcagaa ggggccccag gagagggctg catttcttga cagcctcatg     3120

ctccagatgc cctctgagct gcctctgagc tcccgaagga tgaggctgac acattgtggc     3180

ctccaagaaa agcacctaga gcagctctgc aaggctctgg gaggaagctg ccacctcggt     3240

cacctccacc tcgacttctc aggcaatgct ctgggggatg aaggtgcagc ccggctggct     3300

cagctgctcc cagggctggg agctctgcag tccttgaacc tcagtgagaa cggtttgtcc     3360

ctggatgccg tgttgggttt ggttcggtgc ttctccactc tgcagtggct cttccgcttg     3420

gacatcagct ttgaaagcca acacatcctc ctgagagggg acaagacaag cagggatatg     3480

tgggccactg gatctttgcc agacttccca gctgcagcca agttcttagg gttccgtcag     3540

cgctgcatcc ccaggagcct ctgcctcagt gagtgtcctc tggagccccc aagcctcacc     3600

cgcctctgtg ccactctgaa ggactgcccg ggacccctgg aactgcaatt gtcctgtgag     3660

ttcctgagtg accagagcct ggagactcta ctggactgct tacctcaact ccctcagctg     3720

agcctgctgc agctgagcca gacgggactg tccccgaaaa gccccttcct gctggccaac     3780

accttaagcc tgtgtccacg ggttaaaaag gtggatctca ggtccctgca ccatgcaact     3840

ttgcacttca gatccaacga ggaggaggaa ggcgtgtgct gtggcaggtt cacaggctgc     3900

agcctcagcc aggagcacgt agagtcactc tgctggttgc tgagcaagtg taaagacctc     3960

agccaggtgg atctctcagc aaacctgctg ggcgacagcg gactcagatg ccttctggaa     4020

tgtctgccgc aggtgcccat ctccggtttg cttgatctga gtcacaacag catttctcag     4080

gaaagtgccc tgtacctgct ggagacactg ccctcctgcc cacgtgtccg ggaggcctca     4140

gtgaacctgg gctctgagca gagcttccgg attcacttct ccagagagga ccaggctggg     4200

aagacactca ggctaagtga gtgcagcttc cggccagagc acgtgtccag gctggccacc     4260

ggcttgagca agtccctgca gctgacggag ctcacgctga cccagtgctg cctgggccag     4320

aagcagctgg ccatcctcct gagcttggtg gggcgacccg cagggctgtt cagcctcagg     4380

gtgcaggagc cgtgggcgga cagagccagg gttctctccc tgttagaagt ctgcgcccag     4440

gcctcaggca gtgtcactga aatcagcatc tccgagaccc agcagcagct ctgtgtccag     4500

ctggaatttc ctcgccagga agagaatcca gaagctgtgg cactcaggtt ggctcactgt     4560

gaccttggag cccaccacag ccttcttgtc gggcagctga tggagacatg tgccaggctg     4620

cagcagctca gcttgtctca ggttaacctc tgtgaggacg atgatgccag ttccctgctg     4680

ctgcagagcc tcctgctgtc cctctctgag ctgaagacat ttcggctgac ctccagctgt     4740

gtgagcaccg agggcctcgc ccacctggca tctggtctgg gccactgcca ccacttggag     4800

gagctggact tgtctaacaa tcaatttgat gaggagggca ccaaggcgct gatgagggcc     4860

cttgagggga aatggatgct aaagaggctg gacctcagtc accttctgct gaacagctcc     4920

accttggcct tgcttactca cagactaagc cagatgacct gcctgcagag cctcagactg     4980

aacaggaaca gtatcggtga tgtcggttgc tgccaccttt ctgaggctct cagggctgcc     5040

accagcctag aggagctgga cttgagccac aaccagattg gagacgctgg tgtccagcac     5100

ttagctacca tcctgcctgg gctgccagag ctcaggaaga tagacctctc agggaatagc     5160

atcagctcag ccgggggagt gcagttggca gagtctctcg ttctttgcag gcgcctggag     5220

gagttgatgc ttggctgcaa tgccctgggg gatcccacag ccctggggct ggctcaggag     5280

ctgccccagc acctgagggt cctacaccta ccattcagcc atctgggccc aggtggggcc     5340

ctgagcctgg cccaggccct ggatggatcc ccccatttgg aagagatcag cttggcggaa     5400

aacaacctgg ctggaggggt cctgcgtttc tgtatggagc tcccgctgct cagacagata     5460

gacctggttt cctgtaagat tgacaaccag actgccaagc tcctcacctc cagcttcacg     5520

agctgccctg ccctggaagt aatcttgctg tcctggaatc tcctcgggga tgaggcagct     5580

gccgagctgg cccaggtgct gccgcagatg ggccggctga agagagtgga cctggagaag     5640

aatcagatca cagctttggg ggcctggctc ctggctgaag gactggccca ggggtctagc     5700

atccaagtca tccgcctctg gaataacccc attccctgcg acatggccca gcacctgaag     5760

agccaggagc ccaggctgga ctttgccttc tttgacaacc agccccaggc cccttggggt     5820

acttgatggc cccctcaaga cctttggaat ccagccaagt gatgcaccca aatgatccac     5880

ctttcgccca ctgggataat tgactcagga aagaagagcc tcggcagggc gctctgcact     5940

ccacccagga ggaaggatac gtgtgtcctg ctgcagtcct cagggagaac ttttttggga     6000

accaggagct gggtctggac aaaggagtac cctgcattac gtgggatatg tgtgatcaat     6060

tggggacatg cgacacacaa tgagggtgtc atgacaatgc atgacacgta cggttatatg     6120

tggcagtgtg accccttgac atgtggcgtt acatgaaagt cagtgtggca cgtgttctgt     6180

ggcatgggtg ctggcatccc aagtagcagg atacatgatt gttggtctat atatgacaca     6240

tgacaaatgt ccatgtcaca ggactcatgg ctggccagat gacctcaggc tggcccaaga     6300

tctaatttat taatttttaa agcaaataca tatttataga ttgtgtgtat ggagcagcta     6360

agtcaggaaa agtcttccgc ccgagctggg aggggagagt gtccatgcac tgaccagtcc     6420

aggggctcaa gggccagggc tctggaacaa gccagggact cagccattaa gtcccctcct     6480

gcctcaatcc tcagcctacc catctataaa cttgatgact cctcccttac ttacatacta     6540

gcttccaagg acaggtggag gtagggccag cctggcggga gtggagaagc ccagtctgtc     6600

ctatgtaagg gacaaagcca ggtctaatgg tactgggtag ggggcactgc caagacaata     6660

agctaggcta ctgggtccag ctactacttt ggtgggattc aggtgagtct ccatgcactt     6720

cacatgttac ccagtgttct tgttacttcc aaggagaacc aagaatggct ctgtcacact     6780

cgaagccagg cttgatcaat aaacacaatg gtattccacg tc                        6822


<210> 403
<211> 1260
<212> DNA
<213> Homo sapiens

<400> 403
agctctctgc tcgccgccgc cgctgtcgcc gccacctcct ctgatctacg aaagtcatgt       60

tacccaacac cggttgaagc agttggagga aaggccttgc catgtattgt tgatgtgaga      120

gatgaacagc agatcagtgc tgcagtggag aaagccatca agaaatttgg aggaattgat      180

attctggtaa ataatgccag tgccattagt ttgaccaata cattggacac acctaccaag      240

agattggatc tgatgatgaa cgtgaacacc agaggcacct accttgcatc taaagcatgt      300

attccttatt tgaaaaagag caaagttgct catatcctca atatcagtcc accactgaac      360

ctaaatccag tttggttcaa acagcactgt gcttatacca ttgctaagta tggtatgtct      420

atgtatgtgc ttggaatggc agaagaattt aaaggtgaaa ttgcagtcaa tgcattatgg      480

cctaaaacag ccatacacac tgctgctatg gatatgctgg gaggacctgg tatcgaaagc      540

cagtgtagaa aagttgatat cattgcagat gcagcatatt ccattttcca aaagccaaaa      600

agttttactg gcaactttgt cattgatgaa aatatcttaa aagaagaagg aatagaaaat      660

tttgacgttt atgcaattaa accaggtcat cctttgcaac cagatttctt cttagatgaa      720

tacccagaag cagttagcaa gaaagtggaa tcaactggtg ctgttccaga attcaaagaa      780

gagaaactgc agctgcaacc aaaaccacgt tctggagctg tggaagaaac atttagaatt      840

gttaaggact ctctcagtga tgatgttgtt aaagccactc aagcaatcta tctgtttgaa      900

ctctccggtg aagatggtgg cacgtggttt cttgatctga aaagcaaggg tgggaatgtc      960

ggatatggag agccttctga tcaggcagat gtggtgatga gtatgactac tgatgacttt     1020

gtaaaaatgt tttcagggaa actaaaacca acaatggcat tcatgtcagg gaaattgaag     1080

attaaaggta acatggccct agcaatcaaa ttggagaagc taatgaatca gatgaatgcc     1140

agactgtgaa ggaaaatata aaaaaaaagt cgactgctat gctcaaaaag taaaaaaagc     1200

tcaacagtta aaatctaatg tttgttttct ttcctgttat attataagga tatgcacgtt     1260


<210> 404
<211> 4935
<212> DNA
<213> Homo sapiens

<400> 404
cttttctctc gaagggcacc cgaagattgt cacgagtcct tagactccaa ctactgcggc       60

agcttccaaa tttcctgaaa accctaagct gggccagccc ggcagcccac gcacttccgg      120

cctcggaccc gccccaaaca cccaagcgcc ccagcgcctc atctctaggt ccggaaataa      180

acgaacatct ccgattatgg ttataccagg gtcgagggtt tccgaatata ttcgattcaa      240

agcttcggca agacgaagaa aaccgagcct gaaagcaggg cgagaaaagg ggcgctgcag      300

ggcggatgga aagaattgat tggtaacgat gtggagacgg aaacatccga ggacatccgg      360

aggaacccgg ggagttctga gtggtaatcg aggggtagag tatggcagtg ggcggggtca      420

tctcggtacg ttcgaagggc gttggcggaa attaccgaag atgcccgaag ccgtcgggac      480

ggacccgagt acctcacgca agatggcgga gctggaggag gtgactctgg acgggaagcc      540

tcttcaggcg ctgcgggtga ccgacctgaa ggccgcactg gagcagcgag gcctagccaa      600

gagcgggcag aagagtgccc tggtcaagcg gctcaaaggg gctctaatgc tagaaaattt      660

acagaaacac tcaacacccc atgctgcatt ccagccaaat tcccagattg gtgaggaaat      720

gagccagaac agtttcataa aacagtatct ggaaaagcag caggagctac ttaggcagcg      780

tctggaacgt gaagctcgag aagctgcaga acttgaagaa gcttcagctg agtcggagga      840

cgagatgatc catcctgagg gagtggcttc cctgctgcct cctgactttc agagcagcct      900

ggagagacca gagctggagc tcagcagaca ttcgcccaga aaaagctcct caatttctga      960

agagaaaggt gactctgatg atgagaaacc aaggaaagga gaaagacgat catctagggt     1020

cagacaggca agagcagcta aactgtctga gggcagccaa cctgctgagg aggaagagga     1080

tcaagaaaca ccttccagaa acctaagggt cagagcagat cgaaatttga aaacagagga     1140

ggaagaagag gaggaggagg aggaggaaga agatgatgaa gaagaggaag gtgatgatga     1200

gggacaaaaa tctagggagg caccaatcct gaaagagttt aaggaagaag gggaagagat     1260

acctagagta aaaccagagg agatgatgga tgagagaccc aaaacaagat cccaggaaca     1320

ggaggtgtta gagagaggag ggagatttac aagatcccag gaagaggcta gaaaaagtca     1380

tctggccaga cagcagcagg agaaggaaat gaaaacaaca tctccccttg aggaggaaga     1440

aagagaaata aaatcttcac aaggcttaaa ggaaaaatcg aagtctcctt cccctcctcg     1500

actgactgaa gatcgaaaga aggcctcact tgtagcgctg ccagagcaaa ctgccagcga     1560

ggaggagact cctccacctt tactaacaaa ggaagcatct tctccaccac ctcatccaca     1620

gctccatagc gaagaagaaa tagagcccat ggaaggccca gcccccgctg tcctcattca     1680

gttatctcct cctaatacag atgctgacac cagggagcta ttagtatctc agcatactgt     1740

ccagttggta ggaggcctgt ctcctttgtc aagtccttca gacaccaaag cagaatctcc     1800

agcagagaaa gtgccagagg agagtgtcct gcctctggtt cagaaaagca cactggctga     1860

ctactcagcc cagaaggatc ttgaacctga gtcagacaga tctgctcagc ccctccctct     1920

aaaaattgag gaattagcac tggccaaagg aatcactgaa gaatgtctga aacagccatc     1980

tttggaacag aaggaaggca gaagagcttc tcataccctt ctcccaagcc acagattgaa     2040

acagtcagct gattcatcct ctagccggtc ctcctcatct tcctcctcca gttctagatc     2100

aagatctcgc tctcctgaca gttcaggttc tcggtctcat tcaccgctca gatccaagca     2160

gagagatgta gcccaggcac gtactcatgc caaccctcgt ggtagaccca agatgggctc     2220

cagatcaaca tcagagtcca gatcaaggtc acgttcacgt tctcgttcag catcaagcaa     2280

cagcagaaaa tctctgagcc ctggagtctc cagggacagc agcaccagct atactgaaac     2340

caaagatccc tcttctggtc aggaggttgc aactccacca gtgccacaac tgcaggtctg     2400

tgagccaaag gagaggactt ccacctcctc atcctctgtc caagcaaggc gtctgagtca     2460

gcctgaatca gctgaaaagc atgtgaccca gaggttacag cctgagcggg ggagcccaaa     2520

gaagtgtgaa gctgaagagg cagagccacc agctgccaca cagccccaaa cctcagagac     2580

tcagacctct catctgccag aatcagaaag aattcatcac actgttgagg agaaggagga     2640

agtgaccatg gacacaagtg aaaacagacc tgaaaatgat gttccagaac ctcccatgcc     2700

tattgcagac caagtcagca atgatgaccg cccggagggc agtgttgaag atgaggagaa     2760

gaaagagagc tcgctgccca aatcattcaa gaggaagatc tccgttgtct cagctaccaa     2820

gggggtgcca gctggaaaca gtgacacaga ggggggccag cctggtcgga aacgacgctg     2880

gggagccagc acagccacca cacagaagaa accttccatc agtatcacca ctgaatcact     2940

aaagagcctc atccccgaca tcaaacccct ggcggggcag gaggctgttg tggatcttca     3000

tgctgatgac tctcgcatct ctgaggatga gacagagcgt aatggcgatg atgggaccca     3060

tgacaagggg ctgaaaatat gccggacagt cactcaggta gtacctgcag agggccagga     3120

gaatgggcag agggaagaag aggaagaaga gaaggaacct gaagcagaac ctcctgtacc     3180

tccccaggtg tcagtagagg tggccttgcc cccacctgca gagcatgaag taaagaaagt     3240

gactttagga gataccttaa ctcgacgttc cattagccag cagaagtccg gagtttccat     3300

taccattgat gacccagtcc gaactgccca ggtgccctcc ccaccccggg gcaagattag     3360

caacattgtc catatctcca atttggtccg tcctttcact ttaggccagc taaaggagtt     3420

gttggggcgc acaggaacct tggtggaaga ggccttctgg attgacaaga tcaaatctca     3480

ttgctttgta acgtactcaa cagtagagga agctgttgcc acccgcacag ctctgcacgg     3540

ggtcaaatgg ccccagtcca atcccaaatt cctttgtgct gactatgccg agcaagatga     3600

gctggattat caccgaggcc tcttggtgga ccgtccctct gaaactaaga cagaggagca     3660

gggaatacca cggcccctgc accccccacc cccacccccg gtccagccac cacagcaccc     3720

ccgggcagag cagcgggagc aggaacgggc agtgcgggaa cagtgggcag aacgggaacg     3780

ggaaatggag cggcgggagc ggactcgatc agagcgtgaa tgggatcggg acaaagttcg     3840

agaagggccc cgttcccgat caaggtcccg tgaccgccgc cgcaaggaac gtgcgaagtc     3900

taaagaaaag aagagtgaga agaaagagaa agcccaggag gaaccacctg ccaagctgct     3960

ggatgacctt ttccgaaaga ccaaggcagc tccctgcatc tattggctcc cactgactga     4020

cagccagatc gttcagaaag aggcagagcg ggccgaacgg gccaaggagc gggagaagcg     4080

gcgaaaggag caagaagaag aagagcaaaa ggagcgggag aaggaagccg agcgggaacg     4140

gaaccgacag ctggagcgag agaaacgtcg ggagcacagt cgggagaggg acagggagag     4200

agagagagaa agggagcggg acagggggga ccgagatcgg gatagggaaa gggaccgaga     4260

acgaggcagg gaaagggatc gcagggacac caagcgccac agcagaagcc ggagtcggag     4320

cacacctgtg cgggaccggg gtgggcgccg ctagctggga aaacactaga gctgcaggta     4380

ccagccactc ggccccaggg ggttatggcc acagagggat aggcacagtc tccaccaccc     4440

tggagccaag ggtctttcac atcacctatc cctacataca taccaaatgg aaaagtggcc     4500

atccttttcc ccccaaacac acccccttaa cctatctctt gggacttagc ccgaccctcc     4560

ctctcatttc ccattaagtc tgagaggcaa gagctaggtt aggcaaggag gtggttggcc     4620

agagatgggg aacagccagg tgccccagtc ctctgatttt tcctccatcc tgcttaccac     4680

ctccctgggt acttacagcc ttctcttggg aacagccggg gccaggactg ggtcacctat     4740

gagctgaatc agcatctcct cctgagtccc agggcccctg cagttcccag tctcttctgt     4800

cctgcagccc ttgcctcttt cccacaggtt ccactttata tccacctttt ccttttgttc     4860

aatttttatt tttatttttt ttattattaa atgatgtggt ctatggaaaa aaaaataaaa     4920

atctgactta gtttt                                                      4935


<210> 405
<211> 1233
<212> DNA
<213> Homo sapiens

<400> 405
actctcgcga gatccctact ggctataaag gcagcgcccc ggagagctct tgcgcgtctt       60

gttcttgcct ggtgtcggtg gttagtttct gcgacttgtg ttgggactgg tgagtgtggg      120

cagtgcggcc cctgcggagt gaggcgcggc gcgcccttct tgcctgttgc ctcttcctcc      180

tcctgtccgg ggcccgcccg cgctcgggtg ggggtgctgt gatgcgtgag gcagccgggg      240

gaggcccgga gtccgagact gcttgagcgc tgcgcacacc cctctcgtgg gccccccacg      300

taggtgcggg aacctggttg aaccccaagc tgataggaag atgtcttcag gaaatgctaa      360

aattgggcac cctgccccca acttcaaagc cacagctgtt atgccagatg gtcagtttaa      420

agatatcagc ctgtctgact acaaaggaaa atatgttgtg ttcttctttt accctcttga      480

cttcaccttt gtgtgcccca cggagatcat tgctttcagt gatagggcag aagaatttaa      540

gaaactcaac tgccaagtga ttggtgcttc tgtggattct cacttctgtc atctagcatg      600

ggtcaataca cctaagaaac aaggaggact gggacccatg aacattcctt tggtatcaga      660

cccgaagcgc accattgctc aggattatgg ggtcttaaag gctgatgaag gcatctcgtt      720

caggggcctt tttatcattg atgataaggg tattcttcgg cagatcactg taaatgacct      780

ccctgttggc cgctctgtgg atgagacttt gagactagtt caggccttcc agttcactga      840

caaacatggg gaagtgtgcc cagctggctg gaaacctggc agtgatacca tcaagcctga      900

tgtccaaaag agcaaagaat atttctccaa gcagaagtga gcgctgggct gttttagtgc      960

caggctgcgg tgggcagcca tgagaacaaa acctcttctg tatttttttt ttccattagt     1020

aaaacacaag acttcagatt cagccgaatt gtggtgtctt acaaggcagg cctttcctac     1080

agggggtgga gagaccagcc tttcttcctt tggtaggaat ggcctgagtt ggcgttgtgg     1140

gcaggctact ggtttgtatg atgtattagt agagcaaccc attaatcttt tgtagtttgt     1200

attaaacttg aactgagacc ttgatgagtc ttt                                  1233


<210> 406
<211> 1538
<212> DNA
<213> Homo sapiens

<400> 406
ctgccagaga ggaagagaaa agaaaggaag aaacattaga aagaaaaagg aaggaaaacg       60

gtataaagag agatcaatta cccaccctta aatagctaga ttgggggggg aggggggtgg      120

aaaagaaagc tgtggaggtg tgccccagca cggctgcttt gaaaggttta tcatctatcc      180

gtttggttta tggagaaaaa gaaaatggta actcagggta accaggagcc gacaacaact      240

cctgacgcaa tggttcagcc ttttactacc atcccatttc caccacctcc gcagaatgga      300

attcccacag agtatggggt gccacacact caagactatg ccggccagac cggtgagcat      360

aacctgacac tctacggaag tacgcaagcc cacggggagc agagcagcaa ctcacccagc      420

acacaaaatg gatctcttac gacagaaggt ggagcacaga cagacggcca gcagtcacag      480

acacaaagta gtgaaaattc agagagtaaa tctaccccga aacggctgca tgtctctaat      540

attcctttcc gcttccggga ccctgacctc cggcagatgt ttgggggatt cgggttcgta      600

actttcgaga atagtgctga tgcagacagg gccagggaga aattacacgg caccgtggta      660

gagggccgta aaatcgaggt gaataatgct acagcacgtg taatgaccaa taagaagatg      720

gtcacaccat atgcaaatgg ttggaaatta agcccagtag ttggagctgt atatggtccg      780

gagttatatg cagcatccag ctttcaagca gatgtgtccc taggcaatga tgcagcagtg      840

cccctatcag gaagaggggg tatcaacact tacattcctt taatcattcc tggcttccct      900

taccctactg cagccaccac ggcagccgct ttcagaggag cccatttgag gggcagaggg      960

cggacagtat atggtgcagt ccgagcggta cctccaacag ccatccccgc ctatccaggt     1020

gtggtttacc aggacggatt ttacggtgct gacctctatg gtggatatgc agcctacaga     1080

tatgcacagc ctgctactgc aaccgcagcc accgctgctg cagccgctgc agccgcttac     1140

agtgacggtt atggcagggt gtacacagcc gacccctacc atgcccttgc ccctgccgct     1200

agctatggag ttggcgctgt ggcgagttta taccgaggtg gctacagccg atttgccccc     1260

tactgaagtg acgtgagacc cctgcaaatg ggacagcccc ccagttcatg aggcctggct     1320

attgcaatat ttactagtag aggaactcta tagcaagatg aagaggaaaa acaaacaaac     1380

aaacaaaaaa aaacacaaaa aaagaaagaa tactttttta tacctcacta tgttctttga     1440

atatgtattt ttcctttaaa tttctgcctt taattctttt gttccaaaga ttgtgcattt     1500

ttttcttttt ttttttaaac tgtggtaaaa aaaaaaaa                             1538


<210> 407
<211> 1771
<212> DNA
<213> Homo sapiens

<400> 407
gaggcagcca tgtcttatcc cgctgatgat tatgagtctg aggcggctta tgacccctac       60

gcttatccca gcgactatga tatgcacaca ggagatccaa agcaggacct tgcttatgaa      120

cgtcagtatg aacagcaaac ctatcaggtg atccctgagg tgatcaaaaa cttcatccag      180

tatttccaca aaactgtctc agatttgatt gaccagaaag tgtatgagct acaggccagt      240

cgtgtctcca gtgatgtcat tgaccagaag gtgtatgaga tccaggacat ctatgagaac      300

agctggacca agctgactga aagattcttc aagaatacac cttggcccga ggctgaagcc      360

attgctccac aggttggcaa tgatgctgtc ttcctgattt tatacaaaat actacaggca      420

catggtcctg ctccccttga actacccaac cagtggctct gggatattat cgatgagttc      480

atctaccagt ttcagtcatt cagtcagtac cgctgtaaga ctgccaagaa gtcagaggag      540

gagattgact ttcttcgttc caatcccaaa atctggaatg ttcatagtgt cctcaatgtc      600

cttcattccc tggtagacaa atccaacatc aaccgacagt tggaggtata cacaagcgga      660

ggtgaccctg agagtgtggc tggggagtat gggcggcact ccctctacaa aatgcttggt      720

tacttcagcc tggtcgggct tctccgcctg cactccctgt taggagatta ctaccaggcc      780

atcaaggtgc tggagaacat cgaactgaac aagaagagta tgtattcccg tgtgccagag      840

tgccaggtca ccacatacta ttatgttggg tttgcatatt tgatgatgcg tcgttaccag      900

gatgccatcc gggtcttcgc caacatcctc ctctacatcc agaggaccaa gagcatgttc      960

cagaggacca cgtacaagta tgagatgatt aacaagcaga atgagcagat gcatgcgctg     1020

ctggccattg ccctcacgat gtaccccatg cgtattgatg agagcattca cctccagctg     1080

cgggagaaat atggggacaa gatgttgcgc atgcagaaag gtgacccaca agtctatgaa     1140

gaacttttca gttactcctg ccccaagttc ctgtcgcctg tagtgcccaa ctatgataat     1200

gtgcacccca actaccacaa agagcccttc ctgcagcagc tgaaggtgtt ttctgatgaa     1260

gtacagcagc aggcccagct ttcaaccatc cgcagcttcc tgaagctcta caccaccatg     1320

cctgtggcca agctggctgg cttcctggac ctcacagagc aggagttccg gatccagctt     1380

cttgtcttca aacacaagat gaagaacctc gtgtggacca gcggtatctc agccctggat     1440

ggtgaatttc agtcagcctc agaggttgac ttctacattg ataaggacat gatccacatc     1500

gcggacacca aggtcgccag gcgttatggg gatttcttca tccgtcagat ccacaaattt     1560

gaggagctta atcgaaccct gaagaagatg ggacagagac cttgatgata ttcacacaca     1620

ttcaggaacc tgttttgatg tattataggc aggaagtgtt tttgctaccg tgaaaccttt     1680

acctagatca gccatcagcc tgtcaactca gttaacaagt taaggaccga agtgtttcaa     1740

gtggatctca gtaaaggatc tttggagcca g                                    1771


<210> 408
<211> 6293
<212> DNA
<213> Homo sapiens

<400> 408
tggggttttg atgtgttgcc caggctggtc ttgaactcct gagcttaagt gatgtgtccg       60

cctgggcctc ccaaagtgct ggaattacag acatgagtgg caataaaagg ggtagcagag      120

cttcctgccc tcaccgtggt gccgagtgcc tgctgccttg ggccgccttg aacctccagg      180

gtttccagct cctcctcctt caccccagtg ccactgccat gatggatgtg agtgaacttg      240

gggagtctgc ccgctacctc cgccagggct accaggagat gacgaaggtg cacactatcc      300

catgggacgg gaagaagcga gtctgggtgc ctgatgaaca ggacgcctac gtggaggccg      360

aggtcaagtc ggaggctacc gggggcagag tcaccgtgga gaccaaagac cagaaggtgc      420

tgatggtgcg tgaagccgag ctgcagccca tgaacccgcc tcgcttcgac ttactggagg      480

acatggccat gatgacgcac ctgaacgagg cctctgtgct gcacaacctg cgccagcgct      540

atgcccgctg gatgatctat acctactcag gcctcttctg tgtcaccatc aacccctaca      600

aatggctccc agtctatacg gcctccgtag tggctgctta caagggaaag cgccgctcag      660

attccccgcc ccatatatat gcggtggcgg acaacgccta caacgacatg ctgcgcaacc      720

gagacaacca gtccatgctg atcaccggag agtcgggggc cggtaagacg gttaacacca      780

agcgggtcat tcagtacttt gccatcgtcg ctgccctggg agacgggccg ggcaagaagg      840

cccaatttct ggcaacaaag acggggggca cccttgagga tcaaatcatc gaggccaacc      900

ctgccatgga ggcctttggc aacgccaaga ccctgaggaa tgataactcc tcccgctttg      960

gcaagttcat ccgcattcac tttggtccct ctgggaagct ggcatccgcg gatattgaca     1020

gctatctcct ggagaagtcg cgggtgatct tccagttgcc tggtgagcgc agctaccatg     1080

tctactacca gatcctctca gggaggaagc cagagctgca ggacatgctg cttctgtcta     1140

tgaaccccta tgactaccac ttctgcagcc agggcgtcat caccgtggac aacatgaatg     1200

atggggagga gctcatcgcc accgaccatg ccatggacat cctaggcttc agcgtggatg     1260

agaaatgtgc ctgctataag atcgtgggcg ccctcctgca ctttggcaac atgaagttca     1320

agcagaagca gcgggaggag caggcggagg ccgatggcac tgagagtgct gacaaggctg     1380

cctacctgat gggggtcagc agtggggacc tcctcaaagg ccttttgcac ccccgggtgc     1440

gtgtagggaa cgagtacgtg accaagggcc agagtgtgga gcaggtggtg tttgctgtgg     1500

gggctctggc caaggccacc tatgaccggc tgttcaggtg gctggtgtct cggatcaacc     1560

agaccctgga cacaaagctg ccccggcagt tcttcatcgg ggttctggac atcgctgggt     1620

ttgagatctt tgagttcaac agcttcgaac agctgtgcat caacttcacc aatgagaaat     1680

tgcagcagtt cttcaaccag cacatgtttg tgctggagca ggaggagtac aagcgggagg     1740

gcatcgactg ggtcttcatc gacttcggcc ttgacctgca gccttgcatc gacctcatcg     1800

agaagccact gggcatcctg tccatcctgg aggaggaatg catgttcccc aaggcctcag     1860

acgccagctt ccgggccaag ctctacgaca accacgcggg gaagtcaccc aatttccagc     1920

agcctcggcc tgacaagaag cgcaagtacc aggcccactt cgaggtggtc cactacgcag     1980

gcgtggtgcc ttacagcatt gtgggctggc tggagaaaaa caaggatccc ctgaatgaga     2040

ccgtggtccc catcttccag aagtcacaga ataggctcct ggcgactctc tatgagaatt     2100

atgcgggctc ctgctccact gagcccccca agtctggggt gaaagagaag cgtaagaagg     2160

cagcatcgtt ccagacggtg tcccagctgc acaaggagaa cctcaacaag ctgatgacca     2220

acctgcgggc cacacagccc cacttcgtcc gctgcattgt ccccaacgag aacaaaaccc     2280

caggggtcat ggatgccttc ttggtgctac accagctgcg ctgcaatggg gtcctggagg     2340

ggatccggat ctgccgccaa gggttcccca acaggttgct ctacaccgac ttccggcagc     2400

ggtaccgtat cctgaacccc agtgccatcc cggatgacac cttcatggac agcaggaagg     2460

ccacagagaa actgctgggc tcgctggact tggatcacac ccagtaccag tttggccaca     2520

ccaaggtgtt cttcaaggct gggcttctag gcgtcctgga agagctccgt gaccagcgcc     2580

tggccaaggt gctgacgctg ctgcaggcgc ggagccgtgg ccgcctcatg cgccttgagt     2640

accagcgcct gctgggaggc agggatgcgc tgttcaccat ccagtggaac atccgtgcct     2700

tcaatgccgt caagaactgg tcatggatga agctcttttt caagatgaag ccgctgctgc     2760

gctcggcgca ggctgaggag gagctggcgg ccctgcgggc agagctgcgg gggttgcgag     2820

gggcgctggc tgcggccgag gccaagcgcc aggaactgga ggagacgcac gtcagcatca     2880

cccaggagaa gaatgacctg gccctgcagc tgcaggctga gcaggacaac ctggcagatg     2940

ccgaggagcg ctgccacttg ctgatcaagt ccaaggtgca gctggagggg aaggtgaagg     3000

agctgagtga gcggctggag gatgaggagg aggtgaacgc tgacctggcc gcccgccggc     3060

gcaagctgga ggacgagtgc acggagctca agaaggacat tgatgacctg aagctgacac     3120

tggccaaagc tgagaaggag aagcaagcca ctgagaacaa ggtgaagaac ctgacggaag     3180

agatggctgc gctggacgag tcagtggccc ggctgaccaa ggagaagaag gcgttgcagg     3240

aggcccacca acaggccctg ggtgacctgc aggccgagga ggaccgtgtg agcgcgctga     3300

ccaaggccaa gctccggctg gagcaacagg tggaggacct ggaatgctcc ctggagcagg     3360

agaagaagct gcgcatggac acggagcggg ccaagcgcaa gctggagggt gacctgaagc     3420

tgacgcagga gtcggtggct gatgctgctc aagacaagca gcagctggag gagaagctca     3480

agaagaagga ctccgagctg agccagctga gcctgcgggt ggaagacgag cagctcttgg     3540

gggcccagat gcagaagaag atcaaggagc tgcaggctcg ggcggaggag ctggaagagg     3600

agctggaggc agagcgggca gcccgggccc gcgtggagaa gcagcgtgca gaggcggcgc     3660

gggagctgga ggagctgagc gagcggctgg aggaggcagg cggcgcatcc gcggggcagc     3720

gcgagggctg ccgcaagcgg gaggcggagc tggggaggct gcggcgggag ctggaggagg     3780

cggcgctgcg gcacgaggcc acagtggcgg cactgcggcg caagcaggcg gagggcgcgg     3840

cggagctggg ggagcaggtg gacagcctgc agcgggtgcg gcagaagctg gagaaggaga     3900

agagtgagct gcgcatggag gtggacgacc tggctgccaa cgtggagact ctgacccgcg     3960

ccaaggccag tgcagagaag ctgtgccgga cctatgagga tcagctaagc gaggccaaga     4020

tcaaggtgga ggagctgcag cggcagctgg cggacgcaag cacgcagcgt gggcgactac     4080

agacggaaag cggggagctg agtcgcctgc tagaggagaa ggagtgtctg atcagtcagc     4140

tgagccgtgg aaaggccctg gccgcccaaa gcctggaaga gttgcggcgc cagctagagg     4200

aggaaagcaa ggccaagagt gccctggccc acgccgtgca ggctctgcgg cacgactgtg     4260

acctcctgcg ggagcaacac gaggaggagg ctgaggccca ggctgagctg cagcggctgc     4320

tgtccaaggc caatgccgag gtggcccagt ggaggagcaa gtacgaagca gatgccatcc     4380

agaggaccga ggagctggag gaggccaaaa aaaagctggc actgcggctg caggaggcag     4440

aggagggcgt ggaggctgcc aacgccaagt gctcatcgtt ggagaaggcc aagctgcggc     4500

tacagacaga gtcagaggat gtaaccctgg agctggagcg ggcgacctca gcagctgctg     4560

cgctggacaa gaagcagcgg cacttggaac gggcactgga ggaacggcgg cggcaggagg     4620

aggagatgca gcgggagctg gaggcggcac agagggagtc ccgtggcctg ggcaccgagc     4680

tcttccggct gcggcacggc cacgaggagg cacttgaagc cctggagacg ctcaagcggg     4740

agaacaagaa cctgcaggag gagatcagcg acctcacaga ccaggtgagt ctcagtggga     4800

agagcatcca ggaactggag aaaaccaaga aggcgctgga aggcgagaag agtgagatcc     4860

aggctgcact ggaggaggca gagggggccc tggagctgga ggagaccaag acgctgcgga     4920

tccagctgga gctctcccag gtcaaagcag aagtggaccg gaagctggca gagaaagacg     4980

aggagtgcgc taacctgagg cgcaaccacc agcgagctgt ggagtccctg caggcctccc     5040

tggatgcaga gacacgggcc cgcaatgagg cgctgcggct caagaagaag atggagggtg     5100

acctcaacga cctggagctg cagctgggcc atgccacccg tcaggccaca gaggcccagg     5160

ctgccacgcg gctgatgcag gcacagctca aggaggagca ggcagggcgg gacgaggagc     5220

agcggctggc agctgagctc cacgagcagg cgcaggctct ggagcgccgg gcctcgctgc     5280

tggctgcgga gctggaggag ctgcgggctg ccctggagca gggcgagcgc agccggcgac     5340

tggcagagca ggagcttttg gaggccaccg agcgcctcaa ccttctgcat tcgcagaaca     5400

caggcctcct aaaccagaag aagaagctgg aggcggactt ggcccagctg agcggggagg     5460

tggaggaggc tgcacaggag aggcgggagg ctgaggagaa ggccaaaaag gccatcactg     5520

atgcggccat gatggccgag gagctgaaga aggagcagga cacaagtgca cacctggaac     5580

ggatgaagaa gacgctggag cagacggtgc gcgagctcca ggcccgcctt gaggaggcag     5640

aacaggccgc cctccgtggc gggaagaagc aggtgcagaa gctggaggcc aaggtacggg     5700

agctggaggc tgagcttgat gcagagcaga agaagcacgc cgaggccctt aagggcgtgc     5760

gcaagcatga gcgccgtgtc aaggagctcg cataccaggc cgaggaggac aggaagaacc     5820

tggctcgcat gcaggacctg gtggacaagc tgcagagcaa ggtcaagagc tacaagcgcc     5880

agtttgagga ggcggagcag caggccaaca ccaacctggc caagtatcgc aaggcccagc     5940

acgagctgga tgatgcggag gagcgggcag acatggcgga aacccaggcc aacaagctgc     6000

gggcacggac ccgggacgcc ctgggcccca agcacaagga gtgacggcct gaccccctgg     6060

gctctaaaga ggaatgtctg ctgttgcaca tctggctgag gccacctgcc ccgatcctgc     6120

catctctgca tcgccccctg ctgccttcag ccttccctgg gccctgaata aacaccacag     6180

ccagtttcct tctcattctt ttctttgggg ttcaggagga aaaacacagt cctagggaca     6240

aaagccaggt ccacagcagt catttttaaa ataaagttat ttaatagtct cca            6293


<210> 409
<211> 4576
<212> DNA
<213> Homo sapiens

<400> 409
agaaggccac gcgagcccgg gagggacgcg gcggcggggg ctgcaggaaa ggcgcgagca       60

gaggcggcgg cgggtgtact gtaggtggtc ggtccggcag cagcccggcc cccggacgca      120

ggacgtggcc ccaggcagcc ctcgcagctc agtgctctag ccggggcaag cccgcgtctc      180

cgcctgctgg acgggcccag gcgagatgta gggctctggg cgcggaggcc gccggtgggg      240

cggctgatcg cggaggatcg cggagggcgc gccgaggatg gagagagcga tggagcaact      300

caaccgcctg acgcgctcgc tgcgccgcgc gcgcaccgtg gagttgcccg aggataatga      360

aactgctgtt tatacattaa tgccaatggt tatggctgat caacacaggt ctgtttctga      420

actactatca aattcaaaat ttgatgtcaa ttatgcattc ggacgtgtga aaagaagctt      480

gcttcacatt gcagcaaatt gtggatcggt ggaatgcttg gttttgctgt taaagaaagg      540

agcaaatcct aactatcaag atatttcagg ctgtacaccc cttcatttgg cagcaagaaa      600

tgggcagaag aaatgtatga gtaaattatt agaatatagc gctgatgtca acatttgtaa      660

taatgaaggc cttacagcaa tacattggct ggctgtgaat gggcggacag aactactcca      720

tgaccttgtg cagcatgtca gtgatgttga tgttgaggat gccatggggc agacagcact      780

gcatgttgcc tgccagaacg gtcacaagac gacagtgcag tgcttgctag acagtggtgc      840

tgatattaac aggccaaatg tatcaggagc aactccattg tactttgctt gcagtcatgg      900

tcagagagat acagcacaga tcctactatt acgaggagcc aaatatctgc cagataaaaa      960

tggagtaact cctctggatt tatgtgtaca gggtggatat ggagagactt gtgaagtatt     1020

aattcaatat cacccgaggc tttttcagac tattattcaa atgacacaga atgaagacct     1080

ccgagaaaac atgttacggc aagttctgga gcatttgtct cagcaaagtg aaagccagta     1140

cctaaagatt ctaacaagcc ttgctgaagt tgctacaaca aatggtcata aactgcttag     1200

cctctctagc aattatgatg ctcaaatgaa gagcctttta aggattgtga gaatgttttg     1260

tcacgtcttt cgaattggtc catcctcccc cagtaatgga attgatatgg gctacaatgg     1320

gaataaaact ccaagaagcc aggtgttcaa gcctctggaa ttgctttggc actcgttaga     1380

tgaatggcta gttttaatag ccacagaatt gatgaaaaac aaaagagact caacagagat     1440

cacttctatt ttactgaaac aaaaaggcca agatcaagat gctgcttcca ttcctccatt     1500

tgaacctcca ggacctggga gctatgaaaa tctgtccact ggcacaaggg aatctaaacc     1560

agatgctctt gcagggagac aggaagccag tgcagattgt caggatgtta tttctatgac     1620

agctaaccgg ctaagtgctg tcattcaagc tttttacatg tgctgttctt gtcagatgcc     1680

tccgggaatg acttcacctc gtttcattga atttgtctgc aaacatgatg aagttttaaa     1740

atgctttgtt aatagaaatc ccaaaattat atttgaccac tttcactttc tccttgaatg     1800

tcctgagttg atgtcaagat tcatgcatat cataaaagca cagcctttta aagatcgctg     1860

tgaatggttc tatgaacatt tgcattcagg acagccagat tcagatatgg tgcacaggcc     1920

agtgaatgaa aatgatatcc tgctggttca cagagattct atttttagga gtagctgtga     1980

agttgtgtca aaagcaaatt gtgcaaagct aaagcaaggg attgctgtac ggttccatgg     2040

agaagaaggc atgggtcaag gtgttgtgcg tgagtggttt gatattctgt ccaatgagat     2100

agtcaatcct gattatgcat tgtttaccca gtcagctgat ggaacaactt ttcagcctaa     2160

tagcaactct tatgtaaatc ctgatcactt gaactatttt cggtttgctg ggcagatctt     2220

gggattagcg ttgaaccaca ggcagctggt caatatttac ttcacacgat ccttctacaa     2280

gcacattctt ggtattcctg taaattacca agatgtggca tccattgatc cagaatatgc     2340

gaaaaatttg caatggattt tagataatga tataagtgat ctgggtctag aactaacttt     2400

ttctgttgag actgatgtgt ttggagcaat ggaagaggtg cctttgaaac ctgggggtgg     2460

gagtattctt gtgacacaaa ataataaagc ggagtacgtc cagcttgtta ctgaacttcg     2520

aatgacaaga gccattcagc ctcagatcaa tgctttttta cagggctttc atatgttcat     2580

tccaccctcc ctcatacagc tttttgatga atatgaattg gagctactgc tttctggcat     2640

gccagaaatt gatgtgagtg attggataaa aaatacagaa tacacaagtg gctatgaaag     2700

agaagatcca gttattcagt ggttctggga agttgtagaa gacattactc aagaggagag     2760

agttcttctc ttacagtttg ttacgggcag ttccagggtc ccacatggtg ggtttgctaa     2820

tatcatgggt ggaagtggat tgcaaaactt tacaatcgct gctgtgccat atactccaaa     2880

tcttttacca acttcaagca catgcatcaa catgctcaag ttacctgaat acccaagtaa     2940

agaaatactc aaggacagac ttcttgtggc actacattgt ggcagctatg gttacacaat     3000

ggcataatga agtctggaaa actcctctga ctactgatgc acaattcaga atggcagaag     3060

taatttggga aaatgtcaac aaaaaagcag cctaaatgca acccataggc agggctgatg     3120

cttccaattt ataaaggatc atcaggtttt ctgtttctct cttttccctt ttatgttttc     3180

tctgtttgtg atacaattag aaaatataaa atcacagtag attttatttt ttaaaatgct     3240

aactgaaagt aatagagact gtcctttttc ataattaatt ttatccaaga ttgtattaag     3300

gcaaaatctg attctacatt ccacctctgc tatgtaactg tcttgttaaa agggtgtttt     3360

ctcctaattt ctgatatatt atatgaggtc atccagctgg tgtgttcttt tgcatgtaaa     3420

ctgccattta tattttagaa aactattgta tagaatggat ttagattgtc tataaagcca     3480

caaatacgta ttttgccaca gtgtattcta tattgcaatg atttttttag cattttaata     3540

ttttaatata tattgtaaaa tttagactga tgatactaac agttgatgaa atgacatata     3600

atttatatat gaaagcttac gctatattgt atgaattatt tgcatctttc agtggccagt     3660

tttccatatg tatatattat ggtctcaatg tttttcttac gcctcatttt aatttataat     3720

gaaggtaaaa ttaaaatgta ttttaccacg tttcttttca ttacttttat ctgtgagctc     3780

tgacacatct gaaaaagtaa tctgatgtgc aaattataat ttaaatatgt taattttttt     3840

gcttcttaaa tttgcttttc atcattaaaa tgtcaagttc aagtgatatg tgcctaatat     3900

cacttggatg ttggtgggtt tttgaatttt tgggtggtta atcagtttta ttttgaaaag     3960

acgtacttga atagttacag catatgtttg aacaggaagt aggaacatgc atacacgaag     4020

aaatgctaac ggaaggattt gttatgttta ggatcttccc ttggaaacta aaaatagaat     4080

attaatgaca ttactgtttg tagaatgaca tatgcagatt ttctcataag cagtcattgt     4140

gtttgccagt aatgtttgag agacatgtaa gttgaaagtt ttgctaaatt ataaagctcc     4200

tttaattcgt tggttttgat tctcttattc tcttgtcttt tctaaatgtt aacaaaatat     4260

atcttaacag attacatgaa atttaggaat tatttaaaag ttaccattag ctctaaaatt     4320

aagattcgga tgctttattt atagtaactg aagctaataa tgttttatgt tttgattttt     4380

tgaaatttaa ttgtagaagt cactgccttc tgagttttca aatagataac cacctttaat     4440

attacactgc ttataatact aatgtttaca gatatgtttc tgtttataac catataatac     4500

attggctttg tcatattagt tttttttgca agtagttatg taaaagagat agataataaa     4560

atattaaata actgag                                                     4576


<210> 410
<211> 4267
<212> DNA
<213> Homo sapiens

<400> 410
caacttccgg gtcaaaggtg cctgagccgg cgggtcccct gtgtccgccg cggctgtcgt       60

cccccgctcc cgccacttcc ggggtcgcag tcccgggcat ggagccgcga ccgtgaggcg      120

ccgctggacc cgggacgacc tgcccagtcc ggccgccgcc ccacgtcccg gtctgtgtcc      180

cacgcctgca gctggaatgg aggctctctg gaccctttag aaggcacccc tgccctcctg      240

aggtcagctg agcggttaat gcggaaggtt aagaaactgc gcctggacaa ggagaacacc      300

ggaagttgga gaagcttctc gctgaattcc gagggggctg agaggatggc caccaccggg      360

accccaacgg ccgaccgagg cgacgcagcc gccacagatg acccggccgc ccgcttccag      420

gtgcagaagc actcgtggga cgggctccgg agcatcatcc acggcagccg caagtactcg      480

ggcctcattg tcaacaaggc gccccacgac ttccagtttg tgcagaagac ggatgagtct      540

gggccccact cccaccgcct ctactacctg ggaatgccat atggcagccg agagaactcc      600

ctcctctact ctgagattcc caagaaggtc cggaaagagg ctctgctgct cctgtcctgg      660

aagcagatgc tggatcattt ccaggccacg ccccaccatg gggtctactc tcgggaggag      720

gagctgctga gggagcggaa acgcctgggg gtcttcggca tcacctccta cgacttccac      780

agcgagagtg gcctcttcct cttccaggcc agcaacagcc tcttccactg ccgcgacggc      840

ggcaagaacg gcttcatggt gtcccctatg aaaccgctgg aaatcaagac ccagtgctca      900

gggccccgga tggaccccaa aatctgccct gccgaccctg ccttcttctc cttcatcaat      960

aacagcgacc tgtgggtggc caacatcgag acaggcgagg agcggcggct gaccttctgc     1020

caccaaggtt tatccaatgt cctggatgac cccaagtctg cgggtgtggc caccttcgtc     1080

atacaggaag agttcgaccg cttcactggg tactggtggt gccccacagc ctcctgggaa     1140

ggttcagagg gcctcaagac gctgcgaatc ctgtatgagg aagtcgatga gtccgaggtg     1200

gaggtcattc acgtcccctc tcctgcgcta gaagaaagga agacggactc gtatcggtac     1260

cccaggacag gcagcaagaa tcccaagatt gccttgaaac tggctgagtt ccagactgac     1320

agccagggca agatcgtctc gacccaggag aaggagctgg tgcagccctt cagctcgctg     1380

ttcccgaagg tggagtacat cgccagggcc gggtggaccc gggatggcaa atacgcctgg     1440

gccatgttcc tggaccggcc ccagcagtgg ctccagctcg tcctcctccc cccggccctg     1500

ttcatcccga gcacagagaa tgaggagcag cggctagcct ctgccagagc tgtccccagg     1560

aatgtccagc cgtatgtggt gtacgaggag gtcaccaacg tctggatcaa tgttcatgac     1620

atcttctatc ccttccccca atcagaggga gaggacgagc tctgctttct ccgcgccaat     1680

gaatgcaaga ccggcttctg ccatttgtac aaagtcaccg ccgttttaaa atcccagggc     1740

tacgattgga gtgagccctt cagccccggg gaagatgaat ttaagtgccc cattaaggaa     1800

gagattgctc tgaccagcgg tgaatgggag gttttggcga ggcacggctc caagatctgg     1860

gtcaatgagg agaccaagct ggtgtacttc cagggcacca aggacacgcc gctggagcac     1920

cacctctacg tggtcagcta tgaggcggcc ggcgagatcg tacgcctcac cacgcccggc     1980

ttctcccata gctgctccat gagccagaac ttcgacatgt tcgtcagcca ctacagcagc     2040

gtgagcacgc cgccctgcgt gcacgtctac aagctgagcg gccccgacga cgaccccctg     2100

cacaagcagc cccgcttctg ggctagcatg atggaggcag ccagctgccc cccggattat     2160

gttcctccag agatcttcca tttccacacg cgctcggatg tgcggctcta cggcatgatc     2220

tacaagcccc acgccttgca gccagggaag aagcacccca ccgtcctctt tgtatatgga     2280

ggcccccagg tgcagctggt gaataactcc ttcaaaggca tcaagtactt gcggctcaac     2340

acactggcct ccctgggcta cgccgtggtt gtgattgacg gcaggggctc ctgtcagcga     2400

gggcttcggt tcgaaggggc cctgaaaaac caaatgggcc aggtggagat cgaggaccag     2460

gtggagggcc tgcagttcgt ggccgagaag tatggcttca tcgacctgag ccgagttgcc     2520

atccatggct ggtcctacgg gggcttcctc tcgctcatgg ggctaatcca caagccccag     2580

gtgttcaagg tggccatcgc gggtgccccg gtcaccgtct ggatggccta cgacacaggg     2640

tacactgagc gctacatgga cgtccctgag aacaaccagc acggctatga ggcgggttcc     2700

gtggccctgc acgtggagaa gctgcccaat gagcccaacc gcttgcttat cctccacggc     2760

ttcctggacg aaaacgtgca ctttttccac acaaacttcc tcgtctccca actgatccga     2820

gcagggaaac cttaccagct ccagatctac cccaacgaga gacacagtat tcgctgcccc     2880

gagtcgggcg agcactatga agtcacgttg ctgcactttc tacaggaata cctctgagcc     2940

tgcccaccgg gagccgccac atcacagcac aagtggctgc agcctccgcg gggaaccagg     3000

cgggagggac tgagtggccc gcgggcccca gtgaggcact ttgtcccgcc cagcgctggc     3060

cagccccgag gagccgctgc cttcaccgcc ccgacgcctt ttatcctttt ttaaacgctc     3120

ttgggtttta tgtccgctgc ttcttggttg ccgagacaga gagatggtgg tctcgggcca     3180

gcccctcctc tccccgcctt ctgggaggag gaggtcacac gctgatgggc actggagagg     3240

ccagaagaga ctcagaggag cgggctgcct tccgcctggg gctccctgtg acctctcagt     3300

cccctggccc ggccagccac cgtccccagc acccaagcat gcaattgcct gtcccccccg     3360

gccagcctcc ccaacttgat gtttgtgttt tgtttggggg gatatttttc ataattattt     3420

aaaagacagg ccgggcgcgg tggctcacgt ctgtaatccc agcactttgg gaggctgagg     3480

cgggcggatc acctgaggtt gggagttcaa gaccagcctg gccaacatgg ggaaaccccg     3540

tctctactaa aaatacaaaa aattagccgg gtgtggtggc gcgtgcctat aatcccagct     3600

actcgggagg ctgaggcagg agaatcgctt gaacccggga ggtggaggtt gcggtgagcc     3660

aagatcgcac cattgcactc cagcctgggc aacaagagcg aaactctgtc tcaaaataaa     3720

taaaaaataa aagacagaaa gcaaggggtg cctaaatcta gacttggggt ccacaccggg     3780

cagcggggtt gcaacccagc acctggtagg ctccatttct tcccaagccc gagcagaggg     3840

tcatgcgggc cccacaggag aagcggccag ggcccgcggg gggcaccacc tgtggacagc     3900

cctcctgtcc ccaagctttc aggcaggcac tgaaacgcac cgaacttcca cgctctgctg     3960

gtcagtggcg gctgtcccct ccccagccca gccgcccagc cacatgtgtc tgcctgaccc     4020

gtacacacca ggggttccgg ggttgggagc tgaaccatcc ccacctcagg gttatatttc     4080

cctctcccct tccctccccg ccaagagctc tgccaggggc gggcaaaaaa aaaagtaaaa     4140

agaaaagaaa aaaaaaaaaa agaaacaaac cacctctaca tattatggaa agaaaatatt     4200

tttgtcgatt cttattcttt tataattatg cgtggaagaa gtagacacat taaacgattc     4260

cagttgg                                                               4267


<210> 411
<211> 3054
<212> DNA
<213> Homo sapiens

<400> 411
tggtgaccaa gatggcggcg gagctggtgg aggccaaaaa catggtgatg agttttcgag       60

tctccgacct tcagatgctc ctgggtttcg tgggccggag taagagtgga ctgaagcacg      120

agctcgtcac cagggccctc cagctggtgc agtttgactg tagccctgag ctgttcaaga      180

agatcaagga gctgtacgag acccgctacg ccaagaagaa ctcggagcct gccccacagc      240

cgcaccggcc cctggacccc ctgaccatgc actccaccta cgaccgggcc ggcgctgtgc      300

ccaggactcc gctggcaggc cccaatattg actaccccgt gctctacgga aagtacttaa      360

acggactggg acggttgccc gccaagaccc tcaagccaga agtccgcctg gtgaagctgc      420

cgttctttaa tatgctggat gagctgctga agcccaccga attagtccca cagaacaacg      480

agaagcttca ggagagcccg tgcatcttcg cattgacgcc aagacaggtg gagttgatcc      540

ggaactccag ggaactgcag cccggagtta aagccgtgca ggtcgtcctg agaatctgtt      600

actcagacac cagctgccct caggaggacc agtacccgcc caacatcgct gtgaaggtca      660

accacagcta ctgctccgtc ccgggctact acccctccaa taagcccggg gtggagccca      720

agaggccgtg ccgccccatc aacctcaccc acctcatgta cctgtcctcg gccaccaacc      780

gcatcactgt cacctggggg aactacggca agagctactc ggtggccctg tacctggtgc      840

ggcagctgac ctcatcggag ctgctgcaga ggctgaagac cattggggta aagcacccgg      900

agctgtgcaa ggcactggtc aaggagaagc tgcgccttga tcctgacagc gagatcgcca      960

ccaccggtgt gcgggtgtcc ctcatctgtc cgctggtgaa gatgcggctc tccgtgccct     1020

gccgggcaga gacctgtgcc cacctgcagt gcttcgacgc cgtcttctac ctgcagatga     1080

acgagaagaa gcccacctgg atgtgccccg tgtgcgacaa gccagccccc tacgaccagc     1140

tcatcatcga cgggctcctc tcgaagatcc tgagcgagtg tgaggacgcc gacgagatcg     1200

agtacctggt ggacggctcg tggtgcccga tccgcgccga aaaggagcgc agctgcagcc     1260

cgcagggcgc catcctcgtg ctgggcccct cggacgccaa tgggctcctg cccgccccca     1320

gcgtcaacgg gagcggtgcc ctgggcagca cgggtggcgg cggcccggtg ggcagcatgg     1380

agaatgggaa gccgggcgcc gatgtggtgg acctcacgct ggacagctca tcgtcctcgg     1440

aggatgagga ggaggaggaa gaggaggagg aagacgagga cgaagagggg ccccggccca     1500

agcgccgctg ccccttccag aagggcctgg tgccggcctg ctgaccccgg ccgcacactc     1560

gactttcctg gtgctcacca cgcagagggg cacgggccag cctcgggcgc agagggagga     1620

gtgacctttc tttttctttt tattgtcgtt cgttttgttt ttccaccctt ttgcctggct     1680

cctggcacct gtacctctgg actctcctat cgggggatta aaaaaaaaag taaaatgaca     1740

aaaaaagata caaaaaagaa aaatgaaaca aaaaagtcaa actcttaaaa acaaggccgg     1800

ccacccacac agccgcctcc ccggctggag tccgagccgg gaaggggtag tgggcgggag     1860

ggaccaggac gccgccccgc gccctcccct ccggatgccc cgccgcccgc cgccctctgc     1920

ccacgaccat tccagccagt gcgcggggac ccgggcggcg ggcggtgggg cgcagcccct     1980

ctctggcgac cactttgacg tttgtctctt cctttgcttt ttctctgcaa atgcatcctc     2040

gcccagagac cctcacgcgc cgagcagcga gcgttttagc cgagaagcca tggagtgggt     2100

tggggcgggg aggggcagta gggtgggggg atgggtgggc aggatggggg tacagtgggc     2160

ggctggggag ggtttagcca cagatgtgtt gtattttttg aaagtgcaat aatttggtat     2220

tttgaagacc cggcgtgtgg tcaggaaccc ccggggaagg cgggggccca gggtgcggca     2280

ccgtgtggcg tgggggggtc tcagttttct agccagctac ctcggtaatt ccaattcagg     2340

ttaacttccc tacggaacag cacagatgtc cacagatgtc cacagctgcc gccgccgccg     2400

ccgccaccat accccggtcc ttggggcatg ggttgcggtc gcttcccaag gggcagcagg     2460

gaccccggcc accccggctc tcggtttggg ttgattcctc tcctttttgc tcttggtttt     2520

ccgacgggta cgaggctggc ccggcaccct gtcccccggg agcctcactc ttccagcagg     2580

accagaccag gggcctcctt cctgtcccca ggcgttcccg gcccctcgca ggccccaccc     2640

atgcccttgg cctcagggtc caacaactgg gggagctacc agggctctgc cttcaggagc     2700

ccacagctgg gcacccccct tgccccgcag gagaccgggg cgcaggcggg gcaccggcct     2760

cacctggttc tccaacaccg ctgcctgcgg tctgttttgc ttttgtcctc cccagcccag     2820

aattttcctt tgtataaaca gaactcctag tcaggaagca atatcatttc aggtctaaag     2880

aaagggacgt gcatctggcc gagggcagtt cagtctcact gcagagcccg cagcccgctg     2940

cgcagctcgg cccctcccgc ccgcacgggc agctgaaggc cgctgttttc taatatttgt     3000

attctaattt aattgttttt aaaaaatgca aataaaaaag gtcgaggtga agcc           3054


<210> 412
<211> 830
<212> DNA
<213> Homo sapiens

<400> 412
gtgcattgtg cttccgctcg gggaaagacc gcttccggtg cttccgtcgc tccttgccgg       60

gcataatggc cgcgcagcga cccctgcggg tcctgtgcct ggcgggcttc cggcagagcg      120

agcggggctt ccgtgagaag accggggcgc tgaggaaggc gctgcggggt cgcgccgagc      180

tcgtgtgcct cagcggcccg cacccggtcc ccgacccccc gggccccgag ggcgccagat      240

cagacttcgg gtcctgccct ccggaggagc agcctcgagg ctggtggttt tcagagcagg      300

aggccgacgt tttctccgca ttggaagagc ccgccgtctg caggggcctg gaggaatcac      360

tggggatggt ggcacaggca ctgaacaggc tggggccttt tgacggcctt cttggtttca      420

gccaaggggc tgcgctagca gcccttgtgt gtgccctggg ccaggcaggc gatccccgct      480

tccccttgcc acggtttatc ctcttggtgt ctggtttctg tccccggggc attgggttca      540

aggaatccat cctgcaaagg cccttgtcat tgccttcgct ccatgttttt ggggacactg      600

acaaagtcat cccctctcag gagagtgtgc aactggccag ccaatttccc ggagccatca      660

ccctcaccca ctctggtggc cacttcattc cagcagctgc accccagcgt caggcctacc      720

tcaagttctt ggaccagttt gcagagtgaa agatcaagaa atgtctctgc tcctacatcc      780

agctcctcta ggggcagcct ccgtcatcca tgccctccca ggaccctcca                 830


<210> 413
<211> 2510
<212> DNA
<213> Homo sapiens

<400> 413
ataatgaatt gggtaaggaa cagttaataa gaaaatgtgc cttgctaact gtgcacatta       60

caacaaagag ctggcagctc ctgaaggaaa agggcttgtg ccgctgccgt tcaaacttgt      120

cagtcaactc atgccagcag cctcagcgtc tgcctcccca gcacaccctc attacatgtg      180

tctgtctggc ctgatctgtg catctgctcg gagacgctcc tgacaagtcg ggaatttctc      240

tatttctcca ctggtgcaaa gagcggattt ctccctgctt ctcttctgtc acccccgctc      300

ctctccccca ggaggctcct tgatttatgg tagctttgga cttgcttccc cgtctgactg      360

tccttgactt ctagaatgga agaagctgag ctggtgaagg gaagactcca ggccatcaca      420

gataaaagaa aaatacagga agaaatctca cagaagcgtc tgaaaataga ggaagacaaa      480

ctaaagcacc agcatttgaa gaaaaaggcc ttgagggaga aatggcttct agatggaatc      540

agcagcggaa aagaacagga agagatgaag aagcaaaatc aacaagacca gcaccagatc      600

caggttctag aacaaagtat cctcaggctt gagaaagaga tccaagatct tgaaaaagct      660

gaactgcaaa tctcaacgaa ggaagaggcc attttaaaga aactaaagtc aattgagcgg      720

acaacagaag acattataag atctgtgaaa gtggaaagag aagaaagagc agaagagtca      780

attgaggaca tctatgctaa tatccctgac cttccaaagt cctacatacc ttctaggtta      840

aggaaggaga taaatgaaga aaaagaagat gatgaacaaa ataggaaagc tttatatgcc      900

atggaaatta aagttgaaaa agacttgaag actggagaaa gtacagttct gtcttcaata      960

cctctgccat cagatgactt taaaggtaca ggaataaaag tttatgatga tgggcaaaag     1020

tcagtgtatg cagtaagttc taatcacagt gcagcataca atggcaccga tggcctggca     1080

ccagttgaag tagaggaact tctaagacaa gcctcagaga gaaactctaa atccccaaca     1140

gagtatcatg agcctgtata tgccaatccc ttttacaggc ctacaacccc acagagagaa     1200

acggtgaccc ctggaccaaa ctttcaagaa aggataaaga ttaaaactaa tggactgggt     1260

attggtgtaa atgaatccat acacaatatg ggcaatggtc tttcagagga aaggggaaac     1320

aacttcaatc acatcagtcc cattccgcca gtgcctcatc cccgatcagt gattcaacaa     1380

gcagaagaga agcttcacac cccgcaaaaa aggctaatga ctccttggga agaatcgaat     1440

gtcatgcagg acaaagatgc accctctcca aagccaaggc tgagccccag agagacaata     1500

tttgggaaat ctgaacacca gaattcttca cccacttgtc aggaggacga ggaagatgtc     1560

agatataata tcgttcattc cctgcctcca gacataaatg atacagaacc ggtgacaatg     1620

attttcatgg ggtatcagca ggcagaagac agtgaagaag ataagaagtt tctgacagga     1680

tatgatggga tcatccatgc tgagctggtt gtgattgatg atgaggagga ggaggatgaa     1740

ggagaagcag agaaaccgtc ctaccacccc atagctcccc atagtcaggt gtaccagcca     1800

gccaaaccaa caccacttcc tagaaaaaga tcagaagcta gtcctcatga aaacacaaat     1860

cataaatccc cccacaaaaa ttccatatct ctgaaagagc aagaagaaag cttaggcagc     1920

cctgtccacc attccccatt tgatgctcag acaactggag atgggactga ggatccatcc     1980

ttaacagctt taaggatgag aatggcaaag ctgggaaaaa aggtgatcta agagttgtac     2040

cacctatata aacatccttt gaagaagaaa ctaagaagca tttgcaaatt tctcttctgg     2100

atattttgtt tattttttct gaagtccaaa aaattatcat tacagtgtac catattaagc     2160

catgtgaata agtagtagtc attatttgtg aaaaattccc aaaaagctgg ggaaaacaaa     2220

tgtgtaactt ttccagttac ttgacacgat tcagtggggg aaaaccagca ttttttattc     2280

tattgatacc aaagcatttc taataagagc ttgttaaatt taagaataaa gttatttaaa     2340

atattctgag tatagtatat taactggcat tgtaattttg atgatacaaa gattgaaaga     2400

tcataggaaa gcattgccct tcatcacaga agtattcaac tctgacaaat aaatatgtca     2460

tcctgaatta ataatgcctt aataaaagta catcctcctg ctaactatca                2510


<210> 414
<211> 1909
<212> DNA
<213> Homo sapiens

<400> 414
gatttggcgg gagtcttgac cgccgccggg ctcttggtac ctcagcgcga gcgccaggcg       60

tccggccgcc gtggctatgt tcgtgtccga tttccgcaaa gagttctacg aggtggtcca      120

gagccagagg gtccttctct tcgtggcctc ggacgtggat gctctgtgtg cgtgcaagat      180

ccttcaggcc ttgttccagt gtgaccacgt gcaatatacg ctggttccag tttctgggtg      240

gcaagaactt gaaactgcat ttcttgagca taaagaacag tttcattatt ttattctcat      300

aaactgtgga gctaatgtag acctattgga tattcttcaa cctgatgaag acactatatt      360

ctttgtgtgt gacacccata ggccagtcaa tgtcgtcaat gtatacaacg atacccagat      420

caaattactc attaaacaag atgatgacct tgaagttccc gcctatgaag acatcttcag      480

ggatgaagag gaggatgaag agcattcagg aaatgacagt gatgggtcag agccttctga      540

gaagcgcaca cggttagaag aggagatagt ggagcaaacc atgcggagga ggcagcggcg      600

agagtgggag gcccggagaa gagacatcct ctttgactac gagcagtatg aatatcatgg      660

gacatcgtca gccatggtga tgtttgagct ggcttggatg ctgtccaagg acctgaatga      720

catgctgtgg tgggccatcg ttggactaac agaccagtgg gtgcaagaca agatcactca      780

aatgaaatac gtgactgatg ttggtgtcct gcagcgccac gtttcccgcc acaaccaccg      840

gaacgaggat gaggagaaca cactctccgt ggactgcaca cggatctcct ttgagtatga      900

cctccgcctg gtgctctacc agcactggtc cctccatgac agcctgtgca acaccagcta      960

taccgcagcc aggttcaagc tgtggtctgt gcatggacag aagcggctcc aggagttcct     1020

tgcagacatg ggtcttcccc tgaagcaggt gaagcagaag ttccaggcca tggacatctc     1080

cttgaaggag aatttgcggg aaatgattga agagtctgca aataaatttg ggatgaagga     1140

catgcgcgtg cagactttca gcattcattt tgggttcaag cacaagtttc tggccagcga     1200

cgtggtcttt gccaccatgt ctttgatgga gagccccgag aaggatggct cagggacaga     1260

tcacttcatc caggctctgg acagcctctc caggagtaac ctggacaagc tgtaccatgg     1320

cctggaactc gccaagaagc agctgcgagc cacccagcag accattgcca gctgcctttg     1380

caccaacctc gtcatctccc aggggccttt cctgtactgc tctctcatgg agggcactcc     1440

agatgtcatg ctgttctcta ggccggcatc cctaagcctg ctcagcaaac acctgctcaa     1500

gtcctttgtg tgttcgacaa agaaccggcg ctgcaaactg ctgcccctgg tgatggctgc     1560

ccccctgagc atggagcatg gcacagtgac cgtggtgggc atccccccag agaccgacag     1620

ctcggacagg aagaactttt ttgggagggc gtttgagaag gcagcggaaa gcaccagctc     1680

ccggatgctg cacaaccatt ttgacctctc agtaattgag ctgaaagctg aggatcggag     1740

caagtttctg gacgcactta tttccctcct gtcctaggaa tttgattctt ccagaatgac     1800

cttcttattt atgtaactgg ctttcattta gattgtaagt tatggacatg atttgagatg     1860

tagaagccat tttttattaa ataaaatgct tattttaggc tccgtcccc                 1909


<210> 415
<211> 3249
<212> DNA
<213> Homo sapiens

<400> 415
gcggccgcag gggtctgggc agggctgggc agtgctgccg gagcaaaagc ggtagcggga       60

gcccggccgg agctgggtct ggagacgccg tggcagcctg aacggagtgt gcgacggatt      120

gggaggtttg tctacagatt ttgagcgttc gaagttgacc cctgactaag tatactttgc      180

tgctccctca gcctttgaaa aaatgtctgt cacatatgat gattccgttg gagtagaagt      240

gtccagcgac agcttctggg aggtcgggaa ctacaagcgg actgtgaagc ggatcgacga      300

tggccaccgc ctgtgcagcg acctcatgaa ctgcctgcat gagcgggcgc gcatcgagaa      360

ggcgtatgcg cagcagctca ctgagtgggc ccggcgctgg aggcagctcg tggagaaagg      420

gccccagtac gggaccgtgg agaaggcctg gatggccttc atgtccgagg cagagagggt      480

gagcgagctg cacctcgagg tgaaggcctc actgatgaac gatgacttcg agaagatcaa      540

gaactggcag aaggaagcct ttcacaagca gatgatgggc ggcttcaagg agaccaagga      600

agctgaggac ggctttcgga aggcacagaa gccctgggcc aagaagctga aagaggtaga      660

agcagcaaag aaagcccacc atgcagcgtg caaagaggag aagctggcta tctcacgaga      720

agccaacagc aaggcagacc catccctcaa ccctgaacag ctcaagaaat tgcaagacaa      780

aatagaaaag tgcaagcaag atgttcttaa gaccaaagag aagtatgaga agtccctgaa      840

ggaactcgac cagggcacac cccagtacat ggagaacatg gagcaggtgt ttgagcagtg      900

ccagcagttc gaggagaaac gccttcgctt cttccgggag gttctgctgg aggttcagaa      960

gcacctagac ctgtccaatg tggctggcta caaagccatt taccatgacc tggagcagag     1020

catcagagca gctgatgcag tggaggacct gaggtggttc cgagccaatc acgggccggg     1080

catggccatg aactggccgc agtttgagga gtggtccgca gacctgaatc gaaccctcag     1140

ccggagagag aagaagaagg ccactgacgg cgtcaccctg acgggcatca accagacagg     1200

cgaccagtct ctgccgagta agcccagcag cacccttaat gtcccgagca accccgccca     1260

gtctgcgcag tcacagtcca gctacaaccc cttcgaggat gaggacgaca cgggcagcac     1320

cgtcagtgag aaggacgaca ctaaggccaa aaatgtgagc agctacgaga agacccagag     1380

ctatcccacc gactggtcag acgatgagtc taacaacccc ttctcctcca cggatgccaa     1440

tggggactcg aatccattcg acgacgacgc cacctcgggg acggaagtgc gagtccgggc     1500

cctgtatgac tatgaggggc aggagcatga tgagctgagc ttcaaggctg gggatgagct     1560

gaccaagatg gaggacgagg atgagcaggg ctggtgcaag ggacgcttgg acaacgggca     1620

agttggccta tacccggcaa attatgtgga ggcgatccag tgatgagtcg gggacaggcc     1680

agcgggggga cggaggcggc gggcccagga gcctcagcca gccacgtggg catccactcc     1740

ttttcctgca agagatgatg gttccattgc tcttggcttc atggtgttcc tggaaggcag     1800

atgagctggt catttcgcct gggactcggc acctttccga gtgcagctgg agggatctga     1860

gcgcaggaag acgcagaaca acagaaatag ccgcccctcc ccgcccactg tgcctgttgg     1920

cctatcatag atctctatgt tcttgacttt gtctctcctt tccgagtcaa tggtgggtta     1980

cactgatctt gttccactga ttactctctc tgacgagtcc atcacctgca acttaaatga     2040

acaagcttac atcccatttt gagtgaagat tttgaggttt ttaatttaaa ggctgtgtac     2100

agttatactt ttttatacac ctgttcattt ctacttaaat tatggcacag attgatgcgc     2160

accagtcttg aggaaacgat ctccctattc ccttaccctg ttactcagcc acgccgtgtg     2220

taggcttagc ctcaggtggc agatgtttga ggaaaggaat tatgccagga aggtgggacc     2280

gggttatggt cgggtttcta ttgggaatgc tctttgtgct tttgggcatc tgaatggaag     2340

ctttacatag aaccttaggt agaactcccc caaatcgcca tatttaaaaa ttattttcac     2400

tctattcttg cttaaaactg tactcttttg caaattaaca attttatcac tgattcagag     2460

ttaaaaagaa gactaacttt tcaagcaaat gcatctgtaa agatgcttta gattagactg     2520

tcatgtctca gtgtctatct gtatatatta tttgatattc agagaatcta aagcactcgt     2580

ctactgtttt aatgagattt aacagctttt aacagtgagt ttcgtttgta aactgcttga     2640

agtctgtggc attcaggcac acgtctggct ggccggctgg gtctcctccc gggctcagtg     2700

ggcctggggc ctctctgacg tggtgcctgc tggagggagg ctcgtcgtca ccagctgact     2760

gctggtccgg cttctgaccg gcctttgtcc tggctccgta gcagaacact gtaaaagtgc     2820

ccgcgtcttt gcagtagttg cagatttcag tcgtcgtgtt acttgtgcac aaacagaagc     2880

tgggtcttac ccgcagcacg agtgtctcgg gctgcccgga gtcgcccggg agcaggtgct     2940

gcagccagag ttacgcgggg gccacgcggg ccggcggggg tggggggaac gtgggggaac     3000

ctgtgtttca cgtgactcag cagtgcccgc cgccgtcacc agctatgcat tcactccgtt     3060

tccagtgagc agatgtcttg cttggaaagt ggacctgtgt ctgtgtctgt cctgagaact     3120

taccagcaga aatcctcatt tctgtgctac ggatttacca aaaattgtca agtctttttc     3180

agtttaacag ttcctttaca tgtgtagtat ttgaggaaaa aaatcaataa acagttgatc     3240

tcgtgcata                                                             3249


<210> 416
<211> 3187
<212> DNA
<213> Homo sapiens

<400> 416
acagcgggcg cgcaggccgg ccccggggcc tccatgatgg aggagcgagc ggccgccgcg       60

gtcgccgccg ccgcctcctc ctgccgtccg ctcggctcag gcgcgggccc tggccccact      120

ggggcggccc cggtctccgc ccctgccccc gggccgggcc cggcaggtaa gggaggcggc      180

ggcggaggca gccccgggcc cacggcgggc ccggagcccc tgagcctgcc ggggatcctg      240

cactttatcc agcacgagtg ggcgcgcttc gaagccgaga aagcccgctg ggaggccgag      300

cgcgccgagt tacaggctca ggtggccttc cttcagggag agaggaaagg gcaggagaat      360

ctaaagacgg acctggtgcg gcggatcaag atgctagagt atgcgctgaa gcaggaaagg      420

gccaaatatc ataaactgaa gtttgggaca gacctgaacc agggggagaa gaaagcagat      480

gtgtcagaac aagtctccaa tggccccgtg gaatcggtca ccctggagaa cagcccgttg      540

gtgtggaagg aggggcggca gcttctccga cagtacctgg aagaggtggg ctacacagac      600

accatcctcg acatgcggtc caagcgcgtc cgttccctgc tgggccgctc gctggagctc      660

aacggggcag tggagccgag tgaaggggcc cccagggctc caccaggccc tgcagggctc      720

agtggtgggg agtcgctgct ggtgaaacag atcgaggagc agataaagag gaacgcggca      780

ggcaaagatg gcaaagagcg cttgggcggc tcagtgctgg ggcagatccc cttcctgcag      840

aactgcgagg acgaagacag cgacgaggac gatgagctgg acagcgtgca gcacaagaag      900

cagcgtgtga agctcccatc caaggctctg gtgcccgaaa tggaagacga ggatgaggaa      960

gacgactctg aggatgctat caatgagttt gatttcctgg gctcaggaga ggatggggaa     1020

ggggctccag accctcggcg gtgcactgtg gatgggagcc cccatgagct ggaaagccgt     1080

cgggtcaaac tccaaggcat tctggctgac ctgcgggatg tggatgggct gcccccaaaa     1140

gtgactggcc cgcctcctgg cacaccccag ccccggccac atgaagacgt cttcatcatg     1200

gacactatcg ggggcgggga ggtgagcctg ggggacttgg cagatctcac cgtcaccaac     1260

gacaacgacc tcagctgcga tctgtctgac agcaaagatg cttttaagaa gacgtggaac     1320

cccaagttca ccctgcgctc gcactacgac ggcattcgtt ccctggcctt ccaccacagc     1380

cagtcggctc tgctcaccgc ctccgaggac ggcacgctca agctctggaa cctgcagaag     1440

gcggtcacgg ccaagaagaa tgcggcgcta gatgtggaac ctatacatgc tttccgggct     1500

cacaggggcc cagtgttggc tgtggctatg ggcagcaaca gtgaatactg ctacagtggc     1560

ggggcagatg cctgcatcca tagttggaag attccagacc tcagcatgga tccctatgat     1620

ggctacgacc caagcgtgct gagccacgtc ctggagggcc acggggacgc cgtgtggggc     1680

ctggccttca gtcccacctc ccagcgcctg gcctcctgtt ctgctgatgg caccgtccgc     1740

atctgggacc ccagcagcag cagcccggcc tgcctctgca ccttccccac agccagcgag     1800

cacggggtcc ccacctcagt ggccttcacc agcaccgagc ctgcccacat cgtggcctcc     1860

ttccgctctg gcgacaccgt cttgtatgac atggaggttg gcagtgccct cctcacgctg     1920

gagtcccggg gcagcagcgg tccaacccag atcaaccaag tggtgagtca tccaaaccag     1980

cctctcacca tcaccgccca cgacgacagg ggcatccgct tcctggacaa tcggacaggt     2040

aagccggtgc actccatggt tgcacacctg gacgcagtca cctgcctagc cgtggacccc     2100

aacggcgcat tcctgatgtc aggaagccat gactgctccc tgcgtctctg gagcctggac     2160

aacaaaacgt gcgtgcagga gatcacggcc caccgcaaga agcacgagga ggccatccac     2220

gctgttgcct gccaccccag caaggccctc attgccagtg ctggcgctga tgccctggcc     2280

aaggtcttcg tatgatgccc acctggccct gccctggccg ccacgctggc tggggtgtag     2340

ggccgggcag gtggggctga ggggactccc agcctcgctg gaggtgcaga ggcctggcct     2400

ctgtctgttt gccatggagc ctggtggtgc taacggccct ttccccagga atccctcccc     2460

aacggctgcc ttccccaagc atccagcctg gggatgggcc cctttcagga atcacccccg     2520

aggatggcct cggggtttcc ccctgtgccc tgacagccgc tcctggtatc agagctgctt     2580

tccagagggc agcacagcca gggccgggtg tctttaggga tcagtttttc caagactcca     2640

gaaggtgcca ggttctcccc ttgagctcct gctcccccat cccccatcct cccagacctg     2700

ggcaggagct gtgctgggag aaagggtggc agccgggagc ctcagagctg agccccggcc     2760

tggctgcccc tcccctccgg ccctctccac tgctttccag acactaacca aggcttccag     2820

gccagggatt gcccaacact cctagggcag ccctcccagc gccccatggg gtcgcccatg     2880

ggtagagacg gctttcttgt gcccctccct ggggcatgga gggtggagtg ggcctcgggt     2940

ccccctgaac tccctgtata tctgtataaa taacgggatt ttcatggcgc cgccccaccc     3000

gcattatcac tgtgtgatgg tctcagtcag tctcctccct gtctccactc tttccctcta     3060

tttatttcac tctcttgttt ggttctaccc tgcaccctcg gtccccttcc aggttcctgt     3120

ttataagccc caacccctct gtccccatct tgtatgtgaa aacttgtctc aataaaccct     3180

ttggagt                                                               3187


<210> 417
<211> 1825
<212> DNA
<213> Homo sapiens

<400> 417
atgcgcatgc acacccggct ctcccttcca ggccctcccc accacgtggg cgcggcctac       60

cctcccgcag ggggtaatag aagcgagaac gccggatcct ggggcggggc tggagcttcg      120

tcagttgaac cgctcgcgag gagggttgct agtggagaag caaccttggc catggaccag      180

ccggctggcc tgcaggtgga ctacgtcttc cggggtgtgg agcatgccgt gcgggtgatg      240

gtttctgggc aggtgctgga gctggaggtg gaggaccgga tgacggctga ccagtggcgg      300

ggcgagttcg atgctggctt cattgaagat ttgactcaca agacagggaa cttcaaacag      360

ttcaacatct tctgtcatat gctggagtca gccctcactc agagtagtga gtcagtcacc      420

ctggacctgc tgacctacac agacctggag tccctgcgga accgcaagat ggggggccgc      480

ccaggctcct tggcccccag gtcggcccag ctcaactcca agcgctacct gatcctcatc      540

tactccgtgg agtttgacag gattcactac ccgctgcccc tcccgtacca gggcaagcca      600

gaccccgtgg ttctgcaggg catcatccgg tcactgaagg aggaactggg ccgcctgcaa      660

gggctggatg gccagaacac tcgggacacc cgggagaatg agatctggca tctgcgggag      720

caggtgtcgc gcctggcgtc cgagaagcgg gagctggagg cgcagctggg ccgatcgcgc      780

gaggaggcgc tggccgggcg cgcggcacgc caggaggccg aggcgctgcg cgggctggtg      840

cgcgggctgg agctggagct gcggcaggag cgcggcctcg ggcacagggt ggccggccgt      900

cgcggccagg actgccgccg tctggccaag gagctcgagg aggcgaaggc atcggagcgg      960

agcctgcgcg cccggctgaa gacgctgacc agcgagctgg cattgtacaa gaggggcggc     1020

cgcgggagcc ggggtcgggg ccgccctgcg cgcccctcgc cctcgcccac aggtggtcgc     1080

gcgctccgct tcgaccccac ggcctttgtg aaagccaagg aaaggaagca gagagagatc     1140

cagatgaagc agcagcagcg gaaccgctta ggcagtgggg gaagcgggga cggtccgtcc     1200

gtctcctggt ctcgccagac ccagccccct gctgccttga ctggccgagg ggacgcccct     1260

aaccgctccc gaaaccgcag ctcctcagtg gacagtttcc gcagccgctg ctcgtctgcc     1320

agctcctgca gcgatttgga ggatttctct gagtcgctct ccagaggggg tcaccgccgc     1380

cgtgggaagc ctcccagccc aacgccctgg agtgggtcca atatgaagtc tccccccgtg     1440

gaacgcagcc accatcagaa atctctggcc aactccgggg gctgggtccc catcaaagag     1500

tacagctcgg agcaccaggc ggctgacatg gccgaaatag acgcacgcct gaaggccttg     1560

caggagtaca tgaaccgact ggacatgcgg tcataacgtg gagaaggggt actacccctc     1620

catcccccac ccacttgctg ggtatggtgt ggggggtggg gccagggtgg cctccagccc     1680

tgcccagtcc ctgccctggc cccgtccctc ctgctgcccc tggggtctca ggtgtgtgag     1740

gccctgaccc tgccctctcc ccaggcagtg catgctggga gggaggatgt gtgcattttg     1800

taaataaaca tatttgccct gggga                                           1825


<210> 418
<211> 1836
<212> DNA
<213> Homo sapiens

<400> 418
agccttccag cgcctgcgcg ccgcaccgcg gtggtcgcgg gcgcggacgc ggacgcctgc       60

cccctaagga agcccattgg ccagcggatg gggccagcac cgcctcgcgc cggtggtgga      120

agcacgtgct gggggcggga gcagcaatcg cagccatggc gtcgttactg tggggaggcg      180

acgcaggggc ggcggagagc gagcggctga acagccactt ttcaaacctc agccaacccc      240

ggaagaacct ttggggtatt aagagtactg cagtccgaaa catagatggt tctattaata      300

acatcaatga agatgatgaa gaagatgtag tggatttggc agctaattca ctcttaaaca      360

agttaatcca tcaatcctta gtagaatcca gtcaccgtgt ggaagtttta cagaaggatc      420

ccagctctcc actttactca gtaaagacat ttgaagagct gcggctaaag gaagagttac      480

taaaaggaat ctatgcaatg ggatttaata ggccatctaa aatccaagag atggctctcc      540

ctatgatgct ggcacatcca ccccagaacc tcatagcaca gagccagtct ggaacaggaa      600

agacagcggc atttgtgttg gcaatgttaa gcagagttaa tgccttggaa ttgttcccac      660

agtgcctctg cctagctcct acttatgaat tggctctgca aactggccgt gtggttgagc      720

agatgggaaa attctgtgtg gatgttcaag tgatgtatgc cattcgaggg aatcgaattc      780

ccagaggcac cgacatcact aaacagatta taattggcac tcctgggact gtcctagatt      840

ggtgttttaa actaaaattg attgatttga ctaagattcg tgtgtttgtc ctggatgaag      900

cagatgtgat gattgacact caaggattct cagatcatag tattcgtatt caaagagctc      960

taccctccga atgccaaatg ctcctctttt cagcaacctt tgaggactct gtgtggcact     1020

ttgctgagcg aatcatccct gaccctaatg ttatcaagtt acgcaaagag gagctcacac     1080

tgaacaacat ccggcaatat tacgtgctgt gtgagcacag gaaagacaaa taccaagctc     1140

tgtgcaacat ttatggcagc atcaccattg gtcaggccat catcttctgc cagactcgtc     1200

gaaacgctaa gtggttgacc gtggagatga tacaggatgg ccaccaggtg tctttgttaa     1260

gcggggagct gaccgtggag cagcgagctt ccatcattca gaggtttcgg gatgggaaag     1320

agaaggttct cataacaact aatgtttgtg cccgagggat tgatgtgaag caggtcacaa     1380

ttgttgtgaa ctttgatctc cctgtaaaac aaggagagga gccggactat gagacctacc     1440

tccaccgcat agggcggacg gggcgctttg ggaaaaaagg ccttgccttc aacatgattg     1500

aagtagatga gctgccctcg ctcatgaaaa tccaggacca ctttaacagc agtattaagc     1560

aactcaacgc tgaagacatg gatgaaattg aaaagattga ctattgaaga aagaacttta     1620

ttgtttgtgc agtatcctag tttatgtgag aatgtctcag tgggttttga aggtaatttt     1680

tttatgttga ggctttttcg acgtgaaact gtcacagatg gcaaaataaa tgtcacggta     1740

cttagtttta agacatgagg tctttttgaa gccaaattga tgtgaagctt gtgatccttt     1800

tgaataaaaa aaaggcaaga ttatttctta ttctaa                               1836


<210> 419
<211> 1479
<212> DNA
<213> Homo sapiens

<400> 419
gggcgtcttc ggctcccacc ccggggcgtg ggcctggggg tccctcttca ctgcgcagcc       60

acctctagcc cgccgctttc gggactctca gccttctttt cccttccctg agggccggcc      120

ggcaccacaa cggggccaaa ggcagtaact cggttgaaag gcgcgccctg ggacaggtca      180

gcgggctccg ccatgcgcgg cacgcatccc gcaggagcgg gtgccagagc agggtaggcc      240

gggagttagc agcccagcca ggccgctgga ctcgggctag gggcggggcc agcgcagggg      300

gcgcaggcgc acaccgcctc cgcggcagca tggcggacgc agctcctcaa ctaggcaaga      360

ggaagcgcga attggacgtg gaggaggccc acgccgccag cacagaggaa aaggaggcag      420

gagttggaaa tggtacctgt gctcctgtcc gcttaccgtt ctccggcttc agactgcaga      480

aggtgctgag ggagtctgcg cgggacaaaa tcattttcct acacgggaag gtgaatgagg      540

cctctgggga tggggatgga gaggatgccg ttgtgatcct ggagaagacg ccatttcagg      600

tggaacaggt ggctcagctc ctgacgggca gccctgagct ccagttgcag ttctccaatg      660

atatctacag cacctatcac ttgttccctc caagacaact gaatgatgta aagacgaccg      720

tggtttaccc tgccacagag aaacacctgc agaagtacct gcgccaggac ctccgcctga      780

tccgagagac gggagatgac tacaggaata ttactttacc ccacctggag tcccagagcc      840

tcagcatcca gtgggtgtat aacattctcg acaagaaggc tgaagcggac cggattgttt      900

tcgagaaccc agatccctct gatggttttg tcctcatccc tgacctcaag tggaaccaac      960

agcagctcga tgacttgtac ttgatcgcca tctgccatcg ccggggcatc agatccctac     1020

gcgaccttac tccggagcac ttgccgctgc tcaggaacat cctccaccag gggcaggagg     1080

ccatcctgca gcgctaccgg atgaagggag accatctgcg agtatacctg cactacctgc     1140

cctcctacta ccacctgcat gtgcacttca ccgccctggg cttcgaggcc cccggctcag     1200

gcgtggagcg ggcccacctg ctggctgagg tgatcgagaa cttggagtgt gaccctaggc     1260

actaccagca gcgcacgctc accttcgccc tcagggctga cgaccccctg ctcaagctct     1320

tgcaggaggc tcagcaaagc tgaattaact caggcagaag agcacagatg tgtgggattg     1380

ggggaggagt ggggacaaga ttttttatct ccaagtgaat tttctaaaaa tgtattttat     1440

accggcttat tcctagtatt gaataaacta gcgggctca                            1479


<210> 420
<211> 2788
<212> DNA
<213> Homo sapiens

<400> 420
acgcggacgc ggctggcggc tcggtttctg caaatgcgtg aatgagccgg atgccagcct       60

ctgtcccctg gagcccagcg tgaggaagag gcatgcccca tcagccttca gcttgagccc      120

ggcggccccc gcccccgccc cctgccaccc tgcactgccc cggctccccc gcggccccca      180

cgctgcagtg cggccgggcc ccctccccgc aggggccgcc cccgccgccc acccctagcg      240

cccgtggtgg tggtggtggt ggtggtggtg gtggcccggg ccgcagggcc atgaaactac      300

aggccgtgat ggagacgctg ttgcagcggc agcagcgggc gcgccaggag ctggaggccc      360

ggcagcagct gccccccgat ccccctgctg caccccccgg ccgggcccgg gctgcccccg      420

acgaggacag agagcccgag agtgcccgga tgcagcgggc tcagatggcc gcactggcag      480

ccatgcgggc tgcagctgcg ggcctgggac acccagccag ccccggcggc tctgaggatg      540

ggcccccagg ctcggaggag gaggacgcgg cccgggaggg gacaccgggc tcacccgggc      600

gaggcagaga agggccagga gaggagcact ttgaggacat ggcctccgac gaggacatga      660

agcccaaatg ggaggaggag gagatggagg aagacctcgg ggaggatgag gaggaggagg      720

aggaggatta cgaggatgag gaggaggagg aggacgagga ggggctgggc cccccaggcc      780

ctgccagctt gggcaccacg gcactgttcc cccgaaaggc ccagccaccc caggccttcc      840

gcggcgatgg cgttcccagg gtgctggggg gccaggagcg gccggggcct ggccctgccc      900

accccggagg ggccgcccac gtagccccgc agctgcagcc gcctgaccac ggcgactgga      960

cttacgagga gcagtttaag cagctctacg aactcgacgg ggaccccaag aggaaggaat     1020

tcctggatga cttgttcagc ttcatgcaga agcgagggac acctgtgaac cgcatcccca     1080

tcatggccaa acaggtcctt gacctgttca tgctgtacgt gctggtgacg gagaagggcg     1140

gcctcgtgga ggtcatcaac aagaagctgt ggcgtgagat caccaagggc ctcaacctgc     1200

ccacgtccat caccagtgca gccttcaccc tgcggaccca atacatgaag tacctgtacc     1260

cctacgagtg tgagaagcgg ggcctcagta accccaatga gctccaggca gccatagaca     1320

gcaaccgacg ggagggccgg cgccagagct ttggtggctc cctctttgcc tactcgccag     1380

gcggggcaca cggcatgctc tcctcaccca agctacccgt gtcctccctg ggcctggccg     1440

caagcaccaa tggcagctcc atcacccccg cccctaagat caagaaagag gaggactcag     1500

ccatccccat cacagtccct ggccgcctgc ctgtgtccct ggcgggccac cctgtggtgg     1560

cagcccaggc agcagctgtg caagcagcag ccgcccaagc agctgtggcc gcacaggcag     1620

ctgccctgga acagctgcgg gagaagctgg agtctgcaga gcctccggag aagaagatgg     1680

ccctggtggc cgatgagcag caacggctga tgcaacgtgc actccagcag aacttcctgg     1740

ccatggcggc ccagctgccc atgagcattc ggatcaacag ccaagcctcc gaaagccgcc     1800

aggactctgc tgtgaacctg acgggcacca acggcagcaa cagcatcagc atgtcggtgg     1860

agatcaacgg catcatgtac acaggagttc tgtttgctca gccgccggcc cccacgccaa     1920

cctctgctcc caacaaagga ggcggcggcg gcggcggcag cagcagcaac gcaggcggcc     1980

ggggaggaaa caccggaacc agcggcggcc aggctgggcc agcggggctg tccacaccct     2040

ccacatctac ctcaaataac tcgttgcctt aaccgcatca ctccccaccc gccacccacc     2100

ctggagcccg ccggcctggg cagggggtcc aggtgggcca cacaggggcc aggatggcgg     2160

aagatacggg tggggaggga agatatccag aaaggagcca cagctgacgc caaaaagaaa     2220

agaaaaaaga tatatatata tatatatata tatacacgta tatatataaa gagaatttaa     2280

taaaacaggg gaaaaccaag gaacacttga atttctcagg ttttggacat tcagagagat     2340

gaattgtgag aacagcaaag aaatccatca gaaaaacaga aagaggcaga cgtttcccag     2400

ggcgttcagg cagccctgat ggaccgaagg ctctggtgtc tggtttggcc ccacagcagt     2460

gtgggccgat cctgtttacc tcatacatcc ctgcactgtg tgttttcatt tttgtctgct     2520

ttagttctct tttattttct attcaccaca cactcaccac tcccagcttc tcgtgtccag     2580

tgaaacccct gaaccaagat cactgaattt ttgttttttt cttgttgctt tgggaaattt     2640

ttttttctct gtagggtttt taagaggttt cgggggtttt gttgtgtaaa tattctattt     2700

tattcttggg gggatcaaac cttaggaaaa ggatatctat atatctatat agctatatat     2760

ttgtgttcct tcagggaaac tggtcttg                                        2788


<210> 421
<211> 7853
<212> DNA
<213> Homo sapiens

<400> 421
gagcgagcag ccaagggcgt tgggcaggcg gacgcagagt cgaggaacca agcgctggga       60

tcccgcccag gcggtgccgc ggtgcccctg gtcgctccag ccgcggcggg ggctgggcct      120

gggggtcggc gctgaggcgg gaggggccgc ccgggatgga gacgttgcgg ccggtggcca      180

cagaaacttg agccgcggca gagaaacctc tgctccggtc tctgcgtcct cttcccacac      240

tcccgtgcgc tgctttcggc gtgggccgct gcgctcctag ggagtggggg cgcagggggg      300

gttggccgcg gctgcccgag gccagccccc ccggagtgag ttacgccact atggcggacg      360

gggcaccccg gccccagctt taccgcagcg tctcgttcaa gctgctggag cgctggagcg      420

gcggccccgg gctgagggag gaggacacgg acacccccgg cttgaggcga cgcgcctcgt      480

gccggccgac cacggctgcc cggggccagc cctctcggcg cgtgtccaag ctggcgtctg      540

ggcccctggc cgcccccgcg cagccgcgcc cgctccgcag cctctcgccg tcggttcgcc      600

agctctcccg gcgcttcgac gcgccgcgtc tggacgacgg ctccgctggg acccgagacg      660

gaggcgtctt acccgcggcc gcggaagaag cggccgaggg cccagcgcga ggagcctggc      720

ccagcgtcac cgagatgcgc aagctcttcg gcggtcctgg ctccaggagg cccagcgccg      780

actctgaatc cccaggaacg cccagccccg acggtgccgc gtgggagcct ccggctcggg      840

agtcgcggca gccaccgacg ccaccccctc ggacatgctt ccccctggcg ggtctgcgtt      900

cggcgcggcc cctgaccggg ccggagaccg aagggaggct gcgccggccg cagcagcaac      960

aggagcgggc gcagcgtcca gcggatggtt tacattcttg gcatatcttc tcccaaccgc     1020

aggccggggc ccgggcctcc tgctcctcct cctccatcgc cgcctcctat cctgtcagcc     1080

gcagtcgtgc tgccagctcc agcgaggagg aagaggaggg cccgccgcag ctgcctggag     1140

cccagagtcc ggcctaccac ggcggccact cctcgggcag tgacgacgac cgagacggtg     1200

agggcggcca ccgctgggga gggaggcccg ggctcaggcc tggaagctcc ctattggatc     1260

aggactgcag gcctgacagt gatgggttaa atctaagcag catgaactca gcaggggttt     1320

ctgggagccc tgagccccca acatctccaa gagcccctag agaagaagga ctccgggagt     1380

ggggtagtgg ctctccgccc tgcgtcccag gtccccagga gggacttcgg cctatgtctg     1440

actctgtggg aggagctttc cgtgtggcca aggtgagctt tccctcgtac ctggccagcc     1500

ccgcaggctc ccgcggtagc agccgttatt ccagcacgga gaccctcaag gacgacgacc     1560

tatggtctag taggggttct gggggctggg gcgtgtaccg ctcccctagc tttggagctg     1620

gggaagggct cctgcggtcc caggctcgaa cccgtgccaa aggacctgga ggcacctcta     1680

gggcattgag ggatggagga tttgagcctg aaaagagtcg acagcggaag tccctgtcaa     1740

atccagatat cgcctcagag accctgacgc ttctcagttt cctgcgctca gacctttcag     1800

agctgagggt ccgaaaacct ggtgggagct ccggggaccg tggaagcaac cccctagatg     1860

gcagagactc accatccgca ggtggccctg tggggcaact tgaacccata cccatcccag     1920

ccccagcatc acctggcacg cgccccacac tcaaggactt gacagccact ctgcggagag     1980

caaagtcatt cacctgctct gagaagccca tggcccgccg cctgccccgc accagtgctc     2040

tgaagtccag ctcctccgag ctcctgctca caggccctgg tgccgaggag gatccgctgc     2100

ccctcatcgt ccaggaccaa tatgtgcagg aggcccgcca ggtttttgag aagatccagc     2160

gcatgggtgc ccaacaagat gatggaagcg atgccccccc tggaagccct gactgggcag     2220

gggatgtgac ccgagggcag cggtcccagg aggagctctc aggccctgag tccagtctga     2280

cagatgaagg cattggggca gaccctgagc ctcctgttgc agcattttgc ggcctgggta     2340

ccacagggat gtggcgacct ctttcctcat cctcggccca gacgaaccac catggccctg     2400

ggactgagga cagtctgggc gggtgggccc tggtgtcgcc tgagacccct cccacaccag     2460

gtgccctccg ccgacgacgc aaagtcccac cttcaggttc tggtgggagc gaattgagca     2520

atggggaggc aggggaggcc tacaggtccc tgagtgaccc aattcctcag cgccaccggg     2580

ctgccacctc tgaagagcct actgggttct ctgtggacag caacctcctg ggctcactga     2640

gccccaagac agggctccct gccacctcag ccatggatga gggcttgacc agtggtcaca     2700

gtgactggtc tgtgggcagt gaagagagca agggatatca ggaggttatt cagagcatag     2760

ttcaggggcc tggcaccctg gggcgtgtgg tggacgacag gattgctggc aaagccccca     2820

agaagaaatc cctgagtgac cccagccgcc gtggggagct ggctgggcct ggattcgagg     2880

gccctggagg ggagcccatc cgagaagttg agcccatgct gcctccatcc agcagcgagc     2940

ccatccttgt agagcagcgg gcagagccag aagaacctgg tgccaccagg agccgggcac     3000

agtctgaaag ggccctacct gaggctctgc ctccccctgc cactgcccac cgaaactttc     3060

accttgaccc caagctggct gacattctgt ccccgaggct aatccgccga ggctccaaga     3120

agcgcccagc tcggagtagt caccaggagc ttcggagaga cgagggcagt caggaccaga     3180

ctggcagcct gtctcgggcc cggccctcct ccagacacgt tcgccatgcc agtgtgcccg     3240

ccacatttat gcctattgtg gtgcctgagc caccaacttc tgttggtccc cctgtggctg     3300

tgccagaacc cataggcttc cctacccgag cccatcccac gttgcaggca ccatcgctcg     3360

aggacgtcac caagcagtac atgctgaacc tgcactccgg tgaggtccct gccccagtgc     3420

cagtggacat gccctgcttg cctctggctg caccgccctc tgctgaggcc aagccccctg     3480

aggcagctcg gcctgcagat gagcctaccc ctgccagcaa gtgctgcagc aagccacagg     3540

tggacatgcg gaagcacgtg gccatgaccc tgctggacac agagcagtcg tatgtggagt     3600

cgctgcgcac cctgatgcag ggctacatgc agccgctgaa gcagccagag aactccgtgc     3660

tctgtgaccc ttcactggtg gacgagatct tcgaccagat ccccgagctc ctggagcacc     3720

acgagcaatt cctggagcag gttcggcact gcatgcagac ctggcatgcc cagcagaagg     3780

tgggagccct gctcgtccag tcgttctcca aggatgtcct agtaaacatc tattctgcct     3840

atatcgataa cttcctcaat gcaaaggatg ctgtgcgtgt ggccaaggag gcgaggcctg     3900

cctttctcaa gttcctagag caaagcatgc gtgagaacaa ggagaagcag gcgctgtctg     3960

acctcatgat caagcctgtg cagcggatcc cacgctacga gcttctggtg aaggacctcc     4020

tgaagcatac acctgaggac cacccggacc atccactcct gctggaggcg cagcggaaca     4080

tcaagcaggt ggctgagcgc atcaacaagg gtgtgcggag tgccgaggag gcggagcgcc     4140

atgcccgtgt gctgcaggag atagaggctc acatcgaggg catggaggat ctccaggccc     4200

ctctgcggcg gttcctgaga caggagatgg tcattgaagt gaaggcgatc ggtggcaaga     4260

aggaccggtc tctcttcctg ttcacggacc tcatcgtctg caccactctg aagcgaaagt     4320

caggctccct gcggcgcagc tccatgagcc tgtacacggc agccagtgtc attgacacag     4380

ccagcaagta caagatgctg tggaagctgc cgctggaaga cgcagacatc atcaaagggg     4440

catcccaagc caccaatcgg gagaacatcc agaaggccat cagccgcctt gatgaggacc     4500

tcaccaccct gggccaaatg agcaagctct ctgagagcct tggtttcccc caccagagcc     4560

tggacgatgc actgcgggac ctctcagctg ccatgcaccg ggacctgtcg gagaagcagg     4620

cgctgtgcta cgcgctttcc ttcccgccaa ccaagctgga gctgtgcgcc actcggcccg     4680

agggcaccga ctcctacatt tttgagttcc ctcaccctga cgcccgcctt ggttttgaac     4740

aggccttcga tgaggccaag aggaagctgg catccagcaa aagctgtcta gaccctgagt     4800

tcctgaaggc catccccatc atgaaaaccc gcagtggcat gcagttctcc tgtgcggctc     4860

ccaccctgaa cagctgcccg gagccctcgc ctgaggtatg ggtctgcaac agcgacggct     4920

acgtgggcca ggtgtgcctg ctgagcctgc gcgccgagcc ggacgtggag gcctgcatcg     4980

ccgtctgttc cgcccgcatc ctctgcatcg gggcggtgcc cgggctgcag cctcgctgcc     5040

accgggagcc tcctccgtcg ctgaggagtc ctccagagac ggcaccggag cccgccgggc     5100

cggagctgga cgtcgaggcc gctgcagacg aggaagccgc gacgctcgcg gagccggggc     5160

cgcagccctg ccttcacatc tccattgcag gctcgggctt ggagatgacg ccgggcctcg     5220

gcgagggtga cccccgccca gagctggtgc cctttgacag tgactctgac gatgagtctt     5280

cgcccagccc ctcggggacg ctgcagagcc aggccagccg gtccaccatc tcctccagct     5340

ttggcaatga ggagaccccg agttccaagg aggccacggc agagaccacc agctcagagg     5400

aggagcagga gccaggcttc ctgccactgt ctggctcctt tgggcctggt ggtccctgcg     5460

gcaccagccc aatggatggg agagcccttc gccgctccag ccacggctcc ttcacccggg     5520

gcagccttga ggacctgctg agtgtcgacc ctgaggccta ccagagctcc gtgtggctgg     5580

gcactgagga tggctgtgtc cacgtgtacc agtcctccga cagcatccgt gaccgcagga     5640

acagcatgaa gctccagcat gcggcctctg tgacctgcat cttgtatctg aataaccagg     5700

tgtttgtgtc tctggccaat ggagagcttg tggtctacca aagggaagca ggccatttct     5760

gggaccccca gaacttcaaa tcagtgacct tgggcaccca ggggagcccc atcaccaaga     5820

tggtatctgt gggtgggcgg ctgtggtgtg gctgccagaa ccgagtcctt gtcctgagcc     5880

ctgacacgct gcagctggag cacatgtttt acgtgggtca ggattcaagc cgctgcgtgg     5940

cttgcatggt ggactccagc ctgggtgtgt gggtgacatt gaaaggtagt gcccacgtgt     6000

gtctctacca tccagacacc tttgagcagc tggcagaagt agacgtcact cctcccgtgc     6060

acaggatgct ggcaggctcg gatgccatca tccggcagca caaggctgcc tgtctgcgaa     6120

tcacagcgct gctggtgtgt gaggagctgc tgtgggtggg caccagtgct ggtgtcgtcc     6180

tcaccatgcc cacttcgccc ggtactgtca gctgcccacg ggcaccactc agtcccacag     6240

gcctcggcca gggacacacc ggccacgtcc gcttcttggc tgcagtccag ctgccagatg     6300

gcttcaacct gctctgccca accccaccac ctcccccaga cacaggcccc gagaagctgc     6360

catcactgga gcaccgggac tccccttggc accgaggccc cgcccctgcc aggcctaaaa     6420

tgctggttat cagtggaggt gatggctatg aggacttccg actcagcagt gggggcggca     6480

gcagcagtga gactgtgggt cgagacgaca gcacaaacca cctcctcctg tggagggtgt     6540

gaccctgtct gccgtggccc aggactcgcc cgcccacctg ccttcagcct gcttgcctct     6600

ccctagccca cacgcagact ttgaccagga gtatccagcc aggggcacac atgtgcctgc     6660

gtgggctctg ccttgtcttc gcggaagcat tcctgatgga acacccactg gccagccagg     6720

ccatggcttc tcccgaccct ctggctgccc cggtgcttcc agtcatgatc gggtggggga     6780

catgtgggct gaccaggacc tctgaccctg gagcttctac caaagacaca gctgggtctg     6840

gaccccacgg ggctggggag ggccatgtgc aatatttgga gggttttctg gagggcagca     6900

ggaaggctgg ggaattcccc atgtacagta tttatgtttc tttttagatg tgtaccttcc     6960

caagcactta tttatgcagt gacctggtca cctggggtgg gggtgatttg aggaaatgac     7020

atgaggaaaa gaaacctatt cctgccctgg ggaccaccct gggactctaa ccaagccttc     7080

ctggagggac ccatgcgccc ctgagcccca ttccattcat acagacacac acgtacgcac     7140

actgcatgtc caaggcccta aacattgccc gttgacataa actttccagg gccccagcct     7200

gatggggctg ccctcagtcc tctagatcaa gatgctgact attagggggc agtgattgcc     7260

atctggggac ctgtcaggct ttgtcatttc ccagtttgtt ggtggtgcct ttagtggttc     7320

cctaatttgg gaacactgat ggggccttgg acagggcttt ctctcaggta ggagaaatgg     7380

gcccatgatc tcctcacagt cgcccccagt ccttggccct gcttccctgt gtctcatgca     7440

ctggcacata tggtcacctt ggagggcaga cctaggagcc cctctgacca ctgaatccgt     7500

ctccacaccc cttctgccaa gggaagcccc ttcaggaagg accccccaaa gctgaggggc     7560

tgaatgtagc cttttcaaca gagaaggctc ccacttgaga gcagcctcta cctgaccccc     7620

tggaccacag agagccactc tgaccctcag ccccctcgct tcttcagcta aaactccaaa     7680

ggtttggttt cagatggggt ttgttttgtt ctgtttggtt ttggttttgt ttggggtggg     7740

tgggtcattg cggtcttaga ttatgtttct cttgctacca aacagtcatg tattaactct     7800

ctttggatga tgaagtttaa agagtcaata aatagaaaca ccagatgact gca            7853


<210> 422
<211> 4833
<212> DNA
<213> Homo sapiens

<400> 422
ccgcgggcag cggaaaagag gccgtggggg gcctcccagc gctggcagac accgtgaggc       60

tggcagccgc cggcacgcac acctagtccg cagtcccgag gaacatgtcc gcagccaggg      120

cgcggagcag agtcccgggc aggagaacca agggagggcg tgtgctgtgg cggcggcggc      180

agcggcagcg gagccgctag tcccctccct cctgggggag cagctgccgc cgctgccgcc      240

gccgccacca ccatcagcgc gcggggcccg gccagagcga gccgggcgag cggcgcgcta      300

gggggagggc gggggcgggg aggggggtgg gcgaaggggg cgggagggcg tggggggagg      360

gtctcgctct cccgactacc agagcccgag agggagaccc tggcggcggc ggcggcgcct      420

gacactcggc gcctcctgcc gtgctccggg gcggcatgtc cgaggctggc ggggccgggc      480

cgggcggctg cggggcagga gccggggcag gggccgggcc cggggcgctg cccccgcagc      540

ctgcggcgct tccgcccgcg cccccgcagg gctccccctg cgccgctgcc gccgggggct      600

cgggcgcctg cggtccggcg acggcagtgg ctgcagcggg cacggccgaa ggaccgggag      660

gcggtggctc ggcccgaatc gccgtgaaga aagcgcaact acgctccgct ccgcgggcca      720

agaaactgga gaaactcgga gtgtactccg cctgcaaggc cgaggagtct tgtaaatgta      780

atggctggaa aaaccctaac ccctcaccca ctccccccag agccgacctg cagcaaataa      840

ttgtcagtct aacagaatcc tgtcggagtt gtagccatgc cctagctgct catgtttccc      900

acctggagaa tgtgtcagag gaagaaatga acagactcct gggaatagta ttggatgtgg      960

aatatctctt tacctgtgtc cacaaggaag aagatgcaga taccaaacaa gtttatttct     1020

atctatttaa gctcttgaga aagtctattt tacaaagagg aaaacctgtg gttgaaggct     1080

ctttggaaaa gaaaccccca tttgaaaaac ctagcattga acagggtgtg aataactttg     1140

tgcagtacaa atttagtcac ctgccagcaa aagaaaggca aacaatagtt gagttggcaa     1200

aaatgttcct aaaccgcatc aactattggc atctggaggc accatctcaa cgaagactgc     1260

gatctcccaa tgatgatatt tctggataca aagagaacta cacaaggtgg ctgtgttact     1320

gcaacgtgcc acagttctgc gacagtctac ctcggtacga aaccacacag gtgtttggga     1380

gaacattgct tcgctcggtc ttcactgtta tgaggcgaca actcctggaa caagcaagac     1440

aggaaaaaga taaactgcct cttgaaaaac gaactctaat cctcactcat ttcccaaaat     1500

ttctgtccat gctagaagaa gaagtatata gtcaaaactc tcccatctgg gatcaggatt     1560

ttctctcagc ctcttccaga accagccagc taggcatcca aacagttatc aatccacctc     1620

ctgtggctgg gacaatttca tacaattcaa cctcatcttc ccttgagcag ccaaacgcag     1680

ggagcagcag tcctgcctgc aaagcctctt ctggacttga ggcaaaccca ggagaaaaga     1740

ggaaaatgac tgattctcat gttctggagg aggccaagaa accccgagtt atgggggata     1800

ttccgatgga attaatcaac gaggttatgt ctaccatcac ggaccctgca gcaatgcttg     1860

gaccagagac caattttctg tcagcacact cggccaggga tgaggcggca aggttggaag     1920

agcgcagggg tgtaattgaa tttcacgtgg ttggcaattc cctcaaccag aaaccaaaca     1980

agaagatcct gatgtggctg gttggcctac agaacgtttt ctcccaccag ctgccccgaa     2040

tgccaaaaga atacatcaca cggctcgtct ttgacccgaa acacaaaacc cttgctttaa     2100

ttaaagatgg ccgtgttatt ggtggtatct gtttccgtat gttcccatct caaggattca     2160

cagagattgt cttctgtgct gtaacctcaa atgagcaagt caagggctat ggaacacacc     2220

tgatgaatca tttgaaagaa tatcacataa agcatgacat cctgaacttc ctcacatatg     2280

cagatgaata tgcaattgga tactttaaga aacagggttt ctccaaagaa attaaaatac     2340

ctaaaaccaa atatgttggc tatatcaagg attatgaagg agccacttta atgggatgtg     2400

agctaaatcc acggatcccg tacacagaat tttctgtcat cattaaaaag cagaaggaga     2460

taattaaaaa actgattgaa agaaaacagg cacaaattcg aaaagtttac cctggacttt     2520

catgttttaa agatggagtt cgacagattc ctatagaaag cattcctgga attagagaga     2580

caggctggaa accgagtgga aaagagaaaa gtaaagagcc cagagaccct gaccagcttt     2640

acagcacgct caagagcatc ctccagcagg tgaagagcca tcaaagcgct tggcccttca     2700

tggaacctgt gaagagaaca gaagctccag gatattatga agttataagg ttccccatgg     2760

atctgaaaac catgagtgaa cgcctcaaga ataggtacta cgtgtctaag aaattattca     2820

tggcagactt acagcgagtc tttaccaatt gcaaagagta caacccccct gagagtgaat     2880

actacaaatg tgccaatatc ctggagaaat tcttcttcag taaaattaag gaagctggat     2940

taattgacaa gtgatttttt ttcccctctg cttcttagaa actcaccaag cagtgtgcct     3000

aaagcaaggt ggtttagttt tttacaaaga attggacatg atgtattgaa gagacttgta     3060

aatgtaataa ttagcacttt tgaaaaaaca aaaaacctcc ttttagcttt tcagatatgt     3120

atttaaattg aagtcatagg acatttttat tttatggaat agattttaat ctatttacta     3180

ctattaaggt aaattttcta tggcatgtcc attagctatt tcatgataga tgattagggg     3240

tttcctcaaa acctgtgtgt gaggaaattg cacacagtag caaaatttgg ggaaatccat     3300

aacattttca gaccatgaat gaatgtttcc atttttttct aatggaatgt gagagtttac     3360

ttttatttta ttctgaagga ctttaaggaa gggatacatg attttaaaaa agcctgtaag     3420

aggtgaaata tgtgatgttt gaagtctctt tatagacttt ttatatatat tttttaaaac     3480

actcatctag atgaggtgct ttgagcagtt ctgaaaaatg cagttccagg aaagcaactg     3540

ctttggttcc taaggaagaa attctaaata atgcaaactt ttaaaataag catctaggtt     3600

tttgataatt ctgtctactt acaacaaact tgttagtaca taaccactat tttaataatt     3660

attttctcta cacaaatgtg taatatcata tttgactttg cttatgcagg ccataagttc     3720

caaaagataa tttccctgcc cacaaaggca taaacttgaa aacacatgag attgaatcaa     3780

catgctttaa taggaaaaga tgtatggtct atatatgtat caatctggtg aatcctcgtt     3840

ctaataaagg ttctttttct tttctatgat acacacagcc acgctgataa tatgcaaatg     3900

aacattttcc tttatgtctc tccagataat gtttattgtc tgaggtaaat taaattccca     3960

ccagggtttg ctgtcagtat tttaacaccc acattagtat atgcgtccag ggtcataacc     4020

ccctaaaatc catcatgcaa ccttattaat ctgtcttggg attccagttt agtgcttgga     4080

tttatttcct gattacacta catagaaaag tgagacatct gccattccca actctgggaa     4140

aaccaactaa tatacaacca tataaatgaa ggccatcttg atggtctcaa cactaatttt     4200

tatgatgcaa atttatacac tgatttttgt aaaggacaaa gttttaaaag cgtatttaac     4260

ttgatgtttt ctatcagcat aaataaaatg gtcatgaata gtcattaaaa acagttgcca     4320

gtgataatct gcatgaagga aaaagaaccc tgcaaatggc tattgagttg gaagtattgt     4380

ttttgatatg taagagatat tcagaatgct cacactgaaa atgcctcaac tttttaaagt     4440

gtaagaaacc accatgagtg gtgtctagat ttctaatgaa gaatcatgat acagtttgga     4500

ttaagtatct tggactggtt ttaaacagtg ctttgtaccg gatctgctga agcatctgtc     4560

cagctggtat cctgtgaaag tttgttattt tctgagtaga cattcttata gagtattgtc     4620

tttaaaatca gattgtctct tctatattga aagcattttt atgttttcta atttaaaaat     4680

taatattttc ttatagatat tgtgcaataa agctgaagta gaatgtgtgg tttttgcaaa     4740

tgctttaaca gctgataaaa attttacatt tgtaaaatta atatattgta ctggtacaaa     4800

atagttttaa attatatttt aaaaagcttc caa                                  4833


<210> 423
<211> 5499
<212> DNA
<213> Homo sapiens

<400> 423
cgccgcccag gcaaggccgc cctgccttgg gcgcagcgct gccatggctg ggggccgtgg       60

ggcccccggg cgcggccggg acgagcctcc ggagagctac ccgcaacgac aggaccacga      120

gctacaggcc ctggaggcca tttacggcgc ggacttccaa gacctgcggc cggacgcttg      180

cggaccggtc aaagagcccc ctgaaatcaa tttagttttg taccctcaag gcctaactgg      240

tgaagaagta tatgtaaaag tggatttgag ggttaaatgc ccacctacct atccagatgt      300

agttcctgaa atagagttaa aaaatgccaa aggtctatca aatgaaagtg tcaatttgtt      360

aaaatctcgc ctagaagaac tggccaagaa acactgtggg gaggtgatga tctttgaact      420

ggcttaccac gtgcagtcat ttctcagcga gcataacaag ccccctccca agtcttttca      480

tgaagaaatg ctggaaaggc gggctcagga ggagcagcag aggctgttgg aggccaagcg      540

gaaagaagag caggagcaac gtgaaatcct gcatgagatt cagagaagga aagaagagat      600

aaaagaagag aaaaaaagga aagaaatggc taagcaggaa cgtttggaaa ttgctagttt      660

gtcaaaccaa gatcatacct ctaagaagga cccaggagga cacagaacgg ctgccattct      720

acatggaggc tctcctgact ttgtaggaaa tggtaaacat cgggcaaact cctcaggaag      780

gtctaggcga gaacgtcagt attctgtatg taatagtgaa gattctcctg gctcttgtga      840

aattctgtat ttcaatatgg ggagtcctga tcagctcatg gtgcacaaag ggaaatgtat      900

tggcagtgat gaacaacttg gaaaattagt ctacaatgct ttggaaacag ccactggtgg      960

ctttgtcttg ttgtatgagt gggtccttca gtggcagaaa aaaatgggtc cattccttac     1020

cagtcaagaa aaagagaaga ttgataagtg caaaaagcag attcaaggaa cagaaacaga     1080

attcaactca ctggtaaaat tgagccatcc aaatgtagta cgctaccttg caatgaatct     1140

caaagagcaa gacgactcca tcgtggtgga cattttagtg gagcacatta gtggggtctc     1200

tcttgctgca cacctgagcc actcaggccc catccctgtg catcagcttc gcaggtacac     1260

agctcagctc ctgtcaggcc ttgattatct gcacagcaat tctgtggtgc ataaggtcct     1320

gagtgcatct aatgtcttgg tggatgcaga aggcaccgtc aagattacgg actatagcat     1380

ttctaagcgc ctcgcagaca tttgcaagga ggatgtgttt gagcaaaccc gagttcgttt     1440

tagtgacaat gctctgcctt ataaaacggg gaagaaagga gatgtttggc gtcttggcct     1500

tctgctgctg tccctcagcc aaggacagga atgtggagag taccctgtga ccatccctag     1560

tgacttacca gctgactttc aagattttct aaagaaatgt gtgtgcttgg atgacaagga     1620

aagatggagt ccccagcagt tgttgaaaca cagctttata aatccccagc caaaaatgcc     1680

tctagtggaa caaagtcctg aagattctga aggacaagat tatgttgaga ctgttattcc     1740

tagcaaccgg ctacccagtg ctgccttctt tagtgagaca cagagacagt tttcccgata     1800

cttcattgag tttgaagaat tacaacttct tggtaaagga gcttttggag ctgtcatcaa     1860

ggtgcagaac aagttggacg gctgctgcta cgcagtgaag cgcatcccca tcaacccggc     1920

cagccggcag ttccgcagga tcaagggcga agtgacactg ctgtcacggc tgcaccatga     1980

gaacattgtg cgctactaca acgcctggat cgagcggcac gagcggccgg cgggaccggg     2040

gacgccgccc ccggactccg ggcccctggc caaggatgac cgagctgcac gcgggcagcc     2100

ggcgagcgac acagacggcc tggacagcgt agaggccgcc gcgccgccac ccatcctcag     2160

cagctcggtg gagtggagca cttcgggcga gcgctcggcc agtgcccgtt tccccgccac     2220

cggcccgggc tccagcgatg acgaggacga cgacgaggac gagcacggtg gcgtcttctc     2280

ccagtccttc ctgcctgctt cagattctga aagtgatatt atctttgaca atgaagatga     2340

gaacagtaaa agtcagaatc aggatgaaga ttgcaatgaa aagaatggct gccatgaaag     2400

tgagccatca gtgacgactg aggctgtgca ctacctatac atccagatgg agtactgtga     2460

gaagagcact ttacgagaca ccattgacca gggactgtat cgagacaccg tcagactctg     2520

gaggcttttt cgagagattc tggatggatt agcttatatc catgagaaag gaatgattca     2580

ccgggatttg aagcctgtca acattttttt ggattctgat gaccatgtga aaataggtga     2640

ttttggtttg gcgacagacc atctagcctt ttctgctgac agcaaacaag acgatcagac     2700

aggagacttg attaagtcag acccttcagg tcacttaact gggatggttg gcactgctct     2760

ctatgtaagc ccagaggtcc aaggaagcac caaatctgca tacaaccaga aagtggatct     2820

cttcagcctg ggaattatct tctttgagat gtcctatcac cccatggtca cggcttcaga     2880

aaggatcttt gttctcaacc aactcagaga tcccacttcg cctaagtttc cagaagactt     2940

tgacgatgga gagcatgcaa agcagaaatc agtcatctcc tggctgttga accacgatcc     3000

agcaaaacgg cccacagcca cagaactgct caagagtgag ctgctgcccc caccccagat     3060

ggaggagtca gagctgcatg aagtgctgca ccacacgctg accaacgtgg atgggaaggc     3120

ctaccgcacc atgatggccc agatcttctc gcagcgcatc tcccctgcca tcgattacac     3180

ctatgacagc gacatactga agggcaactt ctcaatccgt acagccaaga tgcagcagca     3240

tgtgtgtgaa accatcatcc gcatctttaa aagacatgga gctgttcagt tgtgtactcc     3300

actactgctt ccccgaaaca gacaaatata tgagcacaac gaagctgccc tattcatgga     3360

ccacagcggg atgctggtga tgcttccttt tgacctgcgg atcccttttg caagatatgt     3420

ggcaagaaat aatatattga atttaaaacg atactgcata gaacgtgtgt tcaggccgcg     3480

caagttagat cgatttcatc ccaaagaact tctggagtgt gcatttgata ttgtcacttc     3540

taccaccaac agctttctgc ccactgctga aattatctac actatctatg aaatcatcca     3600

agagtttcca gcacttcagg aaagaaatta cagtatttat ttgaaccata ccatgttatt     3660

gaaagcaata ctcttacact gtgggatccc agaagataaa ctcagtcaag tctacattat     3720

tctgtatgat gctgtgacag agaagctgac gaggagagaa gtggaagcta aattttgtaa     3780

tctgtctttg tcttctaata gtctgtgtcg actctacaag tttattgaac agaagggaga     3840

tttgcaagat cttatgccaa caataaattc attaataaaa cagaaaacag gtattgcaca     3900

gttggtgaag tatggcttaa aagacctaga ggaggttgtt ggactgttga agaaactcgg     3960

catcaagtta caggtcttga tcaatttggg cttggtttac aaggtgcagc agcacaatgg     4020

aatcatcttc cagtttgtgg ctttcatcaa acgaaggcaa agggctgtac ctgaaatcct     4080

cgcagctgga ggcagatatg acctgctgat tccccagttt agagggccac aagctctggg     4140

gccagttccc actgccattg gggtcagcat agctatagac aagatatctg ctgctgtcct     4200

caacatggag gaatctgtta caataagctc ttgtgacctc ctggttgtaa gtgttggcca     4260

gatgtctatg tccagggcca tcaacctaac ccagaaactc tggacagcag gcatcacagc     4320

agaaatcatg tacgactggt cacagtccca agaggaatta caagagtact gcagacatca     4380

tgaaatcacc tatgtggccc ttgtctcgga taaagaagga agccatgtca aggttaagtc     4440

tttcgagaag gaaaggcaga cagagaagcg tgtgctggag actgaacttg tggaccatgt     4500

actgcagaaa ctgaggacta aagtcactga tgaaaggaat ggcagagaag cttccgataa     4560

tcttgcagtg caaaatctga aggggtcatt ttctaatgct tcaggtttgt ttgaaatcca     4620

tggagcaaca gtggttccca ttgtgagtgt gctagccccg gagaagctgt cagccagcac     4680

taggaggcgc tatgaaactc aggtacaaac tcgacttcag acctcccttg ccaacttaca     4740

tcagaaaagc agtgaaattg aaattctggc tgtggatcta cccaaagaaa caatattaca     4800

gtttttatca ttagagtggg atgctgatga acaggcattt aacacaactg tgaagcagct     4860

gctgtcacgc ctgccaaagc aaagatacct caaattagtc tgtgatgaaa tttataacat     4920

caaagtagaa aaaaaggtgt ctgtgctatt tctgtacagc tatagagatg actactacag     4980

aatcttattt taaccctaaa gaactgtcgt taacctcatt caaacagaca gaggcttata     5040

ctggaataat ggaatgttgt acattcatca taatttaaaa ttaaattcta agaagaggct     5100

gggtgcagtg gctcacacct ttaatcccag cactttggga agccaaggca ggaagactgc     5160

ttgaaaccag gagtttgaga ccagcctgag caacaaagca agaccccatc tctataaaaa     5220

ctaaaaaaat tagttgggca tggtggcaca tgcctgtagt cccagctact ccagaggctg     5280

agatggatca tctgagcctc aggaggttga ggctgcagtg agctgtgact gcgccactgc     5340

actccagtct gggacaacag agcaagaccc tgtcttaaaa aaaaaaagaa aaaaaaaatt     5400

tttttctaag aagctgtcct acaaagttga gctttgttag tttttcatgt gtaatatatt     5460

ataaatttat cttttgggat ataataaatg ctttcatat                            5499


<210> 424
<211> 10459
<212> DNA
<213> Homo sapiens

<400> 424
gagtgcagct ggcaccatgg gtgtgctcca gagcaacttc tgcttgctct gagccccctg       60

ccctgcctcc cctttcacca tgtttcctct gacaagattt taagtacagc aattcaagaa      120

gatttctcct cctaaacgac atttatctga agtctattgc ctcttgattg ctggaaaaga      180

atcttaaaat catttcaaaa gtaacttata aacaaactta ttaaaagtga tgaaaggagc      240

attgaaatta attagcacta atttttcact gtgccaaagt gtgcagtgtc cttcagagga      300

aacaataaca gatctggtga gtgtgccatg ccagtgggga gaattgaatg tccctcatct      360

ccctctttcc ctagggacat tagtcatgag tgccgagtgt gcggggtcac agaagtgggt      420

ctttctgcat atgcaaagca catttctggc cagttgcaca aagataacgt tgatgcccag      480

gaaagagaag atgatggaaa aggagaggaa gaggaagaag attattttga caaggaactc      540

attcagttaa taaaacaaag gaaagaacaa agtcgacaag atgaaccttc caatagcaac      600

caagaaataa actctgatga cagacgaccc caatggagac gagaagaccg aattccttac      660

caagacagag agagttacag tcagcctgca tggcatcatc gtggacctcc acagcgggat      720

tggaaatggg aaaaagatgg ctttaataat actaggaaaa acagctttcc acattctttg      780

aggaatggtg gtggaccaag aggacgttcc gggtggcata agggtgttgc aggaggctcc      840

tcgacttggt ttcacaacca tagtaattct ggaggtggtt ggctttcaaa tagtggagca      900

gtagattgga atcataatgg tacaggaagg aattccagtt ggctttctga aggaacaggt      960

ggcttttcca gttggcatat gaacaacagt aacggaaact ggaaatccag tgtacgtagt     1020

acaaataatt ggaattacag tggccctgga gacaaatttc aaccaggcag aaacagaaat     1080

tctaactgtc aaatggaaga catgactatg ctatggaaca agaaatctaa taagtcaaac     1140

aaatacagtc acgacagata taattggcag cggcaagaaa atgacaaact tggtacagtt     1200

gccacatata gaggtccttc tgaaggattt acaagtgata aatttccttc agaaggctta     1260

ctcgacttca attttgagca gctggaaagc caaaccacta aacaagcaga cactgctact     1320

tccaaagtta gtggaaagaa tggcagtgcg gcaagggaaa agcctcgtcg ctggacgcct     1380

tacccttctc agaagactct ggatttacag tcgggattga aagacatcac tggtaacaag     1440

tcagaaatga tagagaaacc tctctttgat tttagcttga taactacagg aatacaggag     1500

ccccaaactg atgaaacacg taattcccca acacagaaaa cacaaaaaga aatacatact     1560

ggatctctta atcacaaggc ctcttctgat tccgctgctt ccttcgaggt ggtgagacag     1620

tgccccactg cagaaaaacc tgaacaagag catacaccaa ataaaatgcc atcattgaaa     1680

tccccactcc ttccatgtcc agccactaaa tcattgtctc aaaagcaaga tccaaagaat     1740

atctcaaaaa acaccaaaac aaattttttt tcccctggag aacactcaaa tccctcgaac     1800

aagcccactg tggaagataa ccatggtcct tacatatcca aactgcgtag ttcatgtcct     1860

catgttttaa aagggaataa aagtacattt ggctctcaaa agcaatctgg tgataattta     1920

aatgatactt tacgaaaggc caaagaggtg ctacagtgtc atgagtcatt gcaaaatcca     1980

cttcttagca cttctaaaag taccaggaac tatgcaaaag caagtagaaa tgtagaagaa     2040

tctgaaaaag ggtctttgaa aattgagttt caagtgcacg cactagaaga tgaaagtgat     2100

ggagagacat ctgacacgga aaagcatgga acaaaaattg gaaccctagg ttctgcaact     2160

acagaattgt tatctggcag cactcgaact gctgatgaga aagaggagga tgaccgcatc     2220

ctgaagactt ctagagagct atccacttcc ccatgtaatc ccatagttcg ccagaaagaa     2280

tctgaattac aaatgacatc tgcagccagt ccacaccctg gcttattgct agacttgaaa     2340

acctctctag aagatgcaca ggttgatgac tctattaaat ctcatgtatc ttatgaaaca     2400

gaaggctttg agagtgctag cttggatgca gagcttcaaa aaagtgacat cagtcagccc     2460

tcgggccctc tcctgcctga actaagtaag cttggctttc ctgcctcact tcagagggat     2520

ctaacccggc acattagttt gaagagcaaa actggagtac accttcctga gccaaacctc     2580

aatagtgccc gccgcattcg caatattagc ggtcaccgaa agagtgagac agagaaggag     2640

tctgggctca agccaaccct acggcagatt ctaaatgcat ctcggagaaa tgtcaactgg     2700

gaacaggtca ttcagcaagt aaccaagaaa aagcaagagc tgggcaaagg cttacccagg     2760

tttggcatag aaatggtacc ccttgttcaa aatgaacaag aagccttaga tttggatggg     2820

gaacctgatc tgtccagtct agaaggattc cagtgggaag gtgtttccat ttcctcgtcc     2880

cctggcttgg caagaaagcg aagcctttct gagagcagcg tgatcatgga cagagctcct     2940

tctgtgtata gcttcttcag tgaggaaggt acaggcaaag aaaatgagcc ccagcagatg     3000

gtttcaccta gtaactcatt gagggctgga cagagccaga aagcaaccat gcacctcaaa     3060

caagaagtga cacctcgggc tgcctccctc cgaacaggtg aaagggctga aaatgttgct     3120

acccaaaggc gacatagtgc acaattatcc tctgaccata taataccttt gatgcatttg     3180

gcaaaagact tgaacagcca ggagaggtct ataccaccgt cagagaatca gaattcccag     3240

gagagtaatg gagagggaaa ctgtctgtca tcaagcgcat cctcagccct tgcgatctcc     3300

agtttagcgg atgcagccac agatagtagc tgtacctctg gtgctgaaca aaatgatggc     3360

caaagtatta gaaagaaacg aagagccact ggagatggat cttctcctga actcccaagt     3420

cttgagagaa aaaataaaag aaggaaaatt aaaggaaaaa aagaacgttc tcaggttgac     3480

cagctgctga atatttcttt aagggaggaa gaacttagta agtcattgca gtgcatggat     3540

aacaatcttc tgcaagcccg tgcagccctt cagacagctt atgtggaagt tcagaggcta     3600

cttatgctca agcagcagat aactatggag atgagtgcac tgaggaccca tagaatacag     3660

attctacagg gattacaaga aacatatgaa ccttctgagc acccagacca ggttccctgt     3720

agcctcacac gagaacgaag gaacagtaga tctcaaacat ccattgatgc cgcactgctg     3780

cccactccct ttttcccact ttttctggag cctccatctt cccatgtgtc tccatcaccc     3840

accggagcct ctcttcaaat aaccacgtct cctactttcc aaacccatgg cagtgtccct     3900

gctccagact catcagttca gattaaacaa gagcccatgt ctcctgaaca agatgagaat     3960

gtgaatgctg tgccaccaag ctctgcctgc aatgtgtcca aggaattact ggaagctaat     4020

agagagatca gtgacagttg tccagtttat ccagtcatca ctgctagatt gtccttacca     4080

gagtcaacag aaagtttcca tgagcctagc caagaactga agttttctgt ggagcaaaga     4140

aataccagaa acagagaaaa ctctccctct tcccaatcag ctggtctttc tagcataaat     4200

aaagaagggg aagagccaac caaaggcaat agtgggtctg aagcctgtac cagttctttt     4260

ctaagattgt cttttgcttc agaaacccct ttggagaagg aaccccactc tccagctgac     4320

cagcctgaac aacaggcaga atccactttg acatcagctg agactagggg aagcaagaaa     4380

aagaagaaac tccggaagaa gaaaagtcta cgggctgccc atgttcctga gaatagtgac     4440

actgaacagg atgttttgac tgttaaacct gtaaggaaag taaaagctgg aaagttaatt     4500

aaagggggga aagtaacaac ctccacttgg gaagacagca ggactggtcg ggagcaggag     4560

agtgtcagag atgagccaga tagtgactcg tctctggaag tcctagaaat tcctaatcct     4620

cagttagaag tagtagccat tgattcttca gaatcaggag aagagaaacc agacagccca     4680

tctaaaaagg atatttggaa ctctacagag caaaacccac tagaaacgtc tcgttctggg     4740

tgtgatgaag ttagctctac cagtgaaatt ggcactcgct ataaagatgg catccctgta     4800

agtgtggcag aaactcagac tgtgatctcc tccataaaag gatcaaagaa ttcttcagaa     4860

atatcttcag agccaggaga tgatgatgaa cccacagaag gaagctttga gggacaccaa     4920

gctgccgtaa atgcaattca gatatttggg aacttgctat atacctgttc agcagataaa     4980

actgttcggg tttataatct ggtgagtcgg aaatgtattg gtgtctttga gggtcatacc     5040

tccaaagtta actgcctcct ggttactcag acctccggga agaatgctgc cctttacacc     5100

gggtccagtg accataccat ccgctgctat aatgttaaga gccgagagtg tgtggagcag     5160

ttacagctgg aagaccgggt cctctgcctc cacagtagat ggcgaatcct ctatgcggga     5220

ctggcaaatg gcactgtggt caccttcaac ataaagaaca acaaacgact tgagatcttt     5280

gaatgccatg gccctcgggc agtcagctgt cttgctacag ctcaggaagg tgcccgaaaa     5340

ctgctggtcg tggggtctta tgactgcaca attagtgtac gcgatgcccg gaatggactg     5400

ctcctcagaa ctctggaggg ccatagcaaa accattcttt gcatgaaggt ggtgaatgat     5460

ctcgtgttca gtggctccag tgatcagtca gtccatgctc acaacattca cactggtgag     5520

ctcgtgcgga tctataaagg tcacaatcat gcagtgactg tggtgaatat cctaggaaaa     5580

gtgatggtga ctgcttgcct ggataaattt gttcgtgtct atgaattaca gtctcatgat     5640

cgattacaag tttatggagg acacaaagac atgattatgt gtatgaccat ccataaaagc     5700

atgatttaca ctggctgtta tgatggcagt attcaggccg tgaggcttaa tctgatgcag     5760

aattaccgct gttggtggca tggttgctct ctgatatttg gcgttgtaga tcatttaaaa     5820

caacacttgc tgaccgacca cactaatccc aacttccaga ctctgaaatg tcgctggaag     5880

aactgcgatg cttttttcac tgctaggaaa ggatccaaac aggatgctgc aggacatatt     5940

gaacgacatg ctgaagatga cagcaaaatt gattcatgaa gttttttgcc tcccacgttg     6000

ggaagtcatt agttgaacta ttttcacatt ggccccccac acaggccact ctcttccctt     6060

tcttggtgaa gtaaggaagg agaaagtggt tactagccag gcatacccct agcataagtc     6120

tgggcagctc tatgggatga taaattacac ttttaagttc ttgctggagg ttttaaatag     6180

atttagacaa atgttaagga accatacttc tctgggacag catggcatat agtgatatat     6240

gctatttgcg ttctccagat gtttattgaa gatacagatc ctaattggtt acccagtttg     6300

accctaatca tatgtatatt ttattgattt cagtttgcaa tttttaattt atgttcttat     6360

gatggtttaa acctatagtc aggcttttaa gtacaagttt gtttaagtgc cagactttga     6420

ggatcagttt taatttctcc atttgtaata gctgggtatt taaactggaa gcaaatagtt     6480

ttctttctta acaattatgt gcagtgtgtg tcactgtttt cttgctttat agatagagct     6540

ggctttaagt gctaaaggac acagtagatt tttgacaaac agtggctgct ctgctgacta     6600

tcttttagga attcaggaag caaatcacat agtgacaagt ccttacagac accacttcta     6660

gtaaatctct gtaaatgtgg atagaaagct cagtgtgagg cagtgcgtag acctaacgtc     6720

tacctttaca tctgctgttg aacctgggca ctacctgtta cagatcctgt caggctgttg     6780

aactggaggt gtacctttat cttcctttct agtgtctgac cctgcaagcc taatgttggt     6840

ttgaaccctt ttggtttgtt cagttgccag cctccatctc tcccactgta tggccgtgcc     6900

tagaccgatg gcagccatcg aatattcctc tgggctcacg gggtgttttc cacccccctg     6960

cagcaactaa gatggtgggg gagagggggt tagaataaag catctgaata cagttttcag     7020

gacctcaagc agacttccta gagacttgtt tctgagacag ttctttgcct tcacttccct     7080

gctagctggg aaagaagagt ggagcagaga ctctgcctgg ccactgagaa cagccaaatt     7140

cacaaaccct cagtggggct ttgtttttgg attttctccg gactcatcag taaacctgta     7200

gaagtgtcgc tttccagcct tttgtttctg gatcctcaaa actcagaacg tggccgggcg     7260

tggtggctca cgcctgtaat cccagcactt tgggaggctg aggcaggcag atcacctgag     7320

gctaggagtt gcagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaataca     7380

aaaagccggg cgtggtgggc gcctgtaatc ccagctgctc aggaggctga ggcaggagaa     7440

tcgcttgaac ccgggaggca gagattgcag taagctgaga tcgtgccact gcactccagc     7500

ctggtgacag agtgagactc cgtctcaaaa aaaaaaaaaa aaactcagct tcttcagaga     7560

gataaaattg ggggaggagc ccagggccac ataccaagct ttgggacatg gtgcctcatg     7620

ctctctggga ttgcagacca tccaggtctg tcttcgcccc tgttagtgca catatatcca     7680

ctcacatgtc ttccctcagg ctatcgggca gggggacttc accagggggt ttatggatag     7740

gcttcaagag ggtctgtgag cccccagaaa ttgtgtgtga gactgagtat gtgttctttt     7800

ttccaggaaa ggctccagtg gttcttactt gatccaaaaa atgtcaagaa ttaatctagg     7860

aggccgggcc tggtggctca cacctgtaat cccagctctt tgggaggccg aggcgggtgg     7920

atcactcaag gtcaggcatt tgagaccagc ctggccaaca tagtgaaacc ccgtctctat     7980

taaaaataca aaaattagct gggtgtggtg gtatgtgcct gtagtctcag ctactcagga     8040

ggctgagaca ggagaatcac ttgaaccctg gaggtagaag ttgcagtgag ccaagatcat     8100

actactgcac tccagcctgg gcgacaagag tgaaactcca cctcaaaaaa aaaaaaaaaa     8160

gagttaatct aggagataat gaatggccta gtactagata atatatggcc ccacaagctc     8220

ttgacttctg tccttgggga aagccatttt gttaaccaca ctagtgagat ttacatgatg     8280

cttaatggag aacagagaag atcttgttgc aaaaggtgta ttaaatattt gtgctgtttc     8340

tgtatgagat tgagaagctt ttcccacctc tcacccctat ttcctataag gatatccaga     8400

gaagccaaac tgttctgtgg gtttgggaat ggtcatttcc cgggaaaatg catctggatc     8460

gatgactaaa cctggccctt ttctctgggc tgtagtgaag ccgcattttc acgctggctg     8520

gcagtgtgct gagagcctcg aatgctctgc ggcgtagtgc ccttctgccc tgcctgacga     8580

tgtatcgaaa agatgagagt gaaggagact ttgtgcagca ggaaacgggt aggtgaggtg     8640

ttgggcagtt gtgggaactt ctgagagtat tacagagtgg tagaatcggt aagaactctg     8700

atttggactt cgctttggtg gaactgtgtg cctatacctg cctgtgtgtg tgcaagtgtg     8760

caggttcctt tgtatgtatg tgtacgtgtg ggaacctgtg tttgtcatat ttttcttcat     8820

ttcacaaagg ctttttttga agcagtggca gtatgccttt gtttcaagaa cacatgaaat     8880

tcttttaaca ccagattagt gtgttacccc aaatgaacgg ttctagccct ctattaagaa     8940

ataaagggac cataagcatt ttggctgctt atggctgtgt gttactactt acaagagtct     9000

tgaaaattat acagaacttt gccttctttt tttaatgtct tccacaatgt tgtgactgat     9060

tataaccctg tttcccctca gagaagagct atggctcagg gatctgtgtt gactctggca     9120

tttagtggct ttgtgaagga aagaaaccat taaatgacct gacaaaaact gactcatgtc     9180

tttaaagtag ttgaagccac ttttagaatg ttactctcgg ttgcttttgt ctaattctaa     9240

tggcttaaag ccaagaaaac catagtataa atctttttgt gtacctatgc tagtgtttaa     9300

atggcagttc gttgtgataa agtatcagtc acttcaagtt ttctgtgaaa gtttttaatt     9360

aggttaaaaa taattttggc atacgtctct actcagttta taaagcagtt ccacaccatg     9420

caaacaaaac tctaacagca aaggttatct tgacctgatg ttacttgaat ctgagagaaa     9480

gtcattactt actactgcac tcctgctttt gtgggaaaaa ttttcttctt ccccagaaga     9540

gttaacagtt gagtgttcag ctcctgactt acctttaatt tagaggcaat attattactg     9600

tttaagtgat tatttgctta acacaggttt tattttgtct ttttgctggt agattataca     9660

agggacaact ttagtgatga ggcatgtgga tgatttggtg ggagtaggta tatacttagt     9720

ggaatggttt attttatgga agagaattca ttggaggtga gattgaagta tattgtgaag     9780

tgggatttga acagcacata tgctctggtt tgctcaaata actgcagttt atgcttacat     9840

ctaaattttg tttctgttac ctaaacggga gcttctagaa ttacgaaggc catacctgcc     9900

acatttataa aataatggtt ttatccctgc ccccaaatca tcaggttcct cgggtttaag     9960

agaagtggtc taatagacag gaatagaagt tgtggtggag gtgatttggg atagactagg    10020

tttccttatg caagtggata tgagctcctc atagaaacca gacctactgt attagacagt    10080

aacctctaac ctcacctcca agcccaagta tatggccctg ctgggttacc tggtgactac    10140

atttcccaga ttcactctaa attcaaggta gtgacccaaa taaattggga aaggaggggg    10200

tcaaggagga aaagctgttg aaaatctttc tcctatttaa gagaaatata tgccctagag    10260

ctgctccagc acccttggtt tctgattttt ttaatattga atatggatta gaagaatgaa    10320

atcagatgac acctgactgc aaaaatgttt ataagcaaat agccttctta cattttggta    10380

taaagctgtg aacttcgtaa ctttgtaaag caagatataa agcaaataca agaggaaaat    10440

aaagtacttt tactaattg                                                 10459


<210> 425
<211> 1078
<212> DNA
<213> Homo sapiens

<400> 425
aggcggtggg gcccacagcc atggcggagc ctgtgcagga ggagctctcg gtcctggccg       60

cgattttctg caggccccac gagtgggagg tgctgagccg ctcagagaca gatgggaccg      120

tgttcagaat tcacacaaaa gctgaaggat ttatggatgt ggatatacct ctggaattgg      180

tgttccattt gccagtcaat tatccttcat gtctacctgg tatctcgatt aactctgaac      240

agttgaccag ggcccagtgt gtgactgtga aagagaattt acttgagcaa gcagagagcc      300

ttttgtcgga gcctatggtt catgagctgg ttctctggat tcagcagaat ctcaggcata      360

tcctcagcca accagaaact ggcagtggca gtgaaaagtg tactttttca acaagcacga      420

ccatggatga tggattgtgg ataactcttt tgcatttaga tcacatgaga gcaaagacta      480

aatatgtcaa aattgtggag aagtgggctt cagatttaag gctgacagga agactgatgt      540

tcatgggtaa aataatactg attttactac agggagacag aaacaacctc aaggtgccaa      600

aaagttaaat gtttctggca tttgaagtca aagagtattc agcgttggat gaattacaaa      660

aggaatttga aactgcagga cttaagaagc ttttctccga atttgtactt gctctggtaa      720

aatgaaatgg aagacaggaa tcttttagta aaatagcagt gttttttgtt gtttttgcat      780

tggatttggg gagtggttaa ttgaaatagt caattttaaa gtttctctga agcaaaatga      840

taggcatcat tctaacttca ggaacaaaag ccagttctgt tttatgaaat attaaacatg      900

aagaaaactt gtatattcta atgtttgcca ggaaaggcta ggttcagtag atgagacatt      960

atttaaaaga taaatttaaa aagatggtaa atgaacactt gtttttatag acaatatttg     1020

tttgaaacta tgtaattttc tggctaattt tcttgtaatt aaatgatttt ttaaaaaa       1078


<210> 426
<211> 5287
<212> DNA
<213> Homo sapiens

<400> 426
ccgcgactgc aagcttcggt agtcctctcc gctgctgtcg ccaggagtca cttcacgaga       60

agccaggtca caaccgtcgg cccttgtctg gaaaagtaaa agtggatcct gccacgttcg      120

gagctccctg gcgcctcgcc cggctggagc tagagaactc gtcctgtggc ggcccccggc      180

gtggggcggg acagcggccc cctggagggg gcagtcccgg gagaacctgc ggcggccgga      240

gcggtaaaaa taagtgacta aagaagcaga cctgggaatc acctaacatg tcgaggagga      300

gatttgattg ccgaagtatt tcaggcctac taactacaac tcctcaaatt ccaataaaaa      360

tggaaaactt taataatttc tatatactta catctaaaga gctagggaga ggaaaatttg      420

ctgtggttag acaatgtata tcaaaatcta ctggccaaga atatgctgca aaatttctaa      480

aaaagagaag aagaggacag gattgtcgag cagaaatttt acacgagatt gctgtgcttg      540

aattggcaaa gtcttgtccc cgtgttatta atcttcatga ggtctatgaa aatacaagtg      600

aaatcatttt gatattggaa tatgctgcag gtggagaaat tttcagcctg tgtttacctg      660

agttggctga aatggtttct gaaaatgatg ttatcagact cattaaacaa atacttgaag      720

gagtttatta tctacatcag aataacattg tacaccttga tttaaagcca cagaatatat      780

tactgagcag catataccct ctcggggaca ttaaaatagt agattttgga atgtctcgaa      840

aaatagggca tgcgtgtgaa cttcgggaaa tcatgggaac accagaatat ttagctccag      900

aaatcctgaa ctatgatccc attaccacag caacagatat gtggaatatt ggtataatag      960

catatatgtt gttaactcac acatcaccat ttgtgggaga agataatcaa gaaacatacc     1020

tcaatatttc tcaagttaat gtagattatt cggaagaaac tttttcatca gtttcacagc     1080

tggccacaga ctttattcag agccttttag taaaaaatcc agagaaaaga ccaacagcag     1140

agatatgcct ttctcattct tggctacagc agtgggactt tgaaaacttg tttcaccctg     1200

aagaaacttc cagttcctct caaactcagg atcattctgt aaggtcctct gaagacaaga     1260

cttctaaatc ctcctgtaat ggaacctgtg gtgatagaga agacaaagag aatatcccag     1320

aggatagcag catggtttcc aaaagatttc gtttcgatga ctcattaccc aatccccatg     1380

aacttgtttc agatttgctc tgttagcact tttttctttg actcatttgg actgaatttg     1440

aaattttata tccactccag tgagattatg atttgtagct tcatatatga catgtttata     1500

ttgtaaatgc acttttccat ggaataattt agggaagtgt tttaatgtta aattactagt     1560

tgctagcatg ttatgatttc atatcctgag atagctctgc agataagaaa atatttaaat     1620

atatgacaaa aagtaaaatt gtacatgtga gtttacatgt taatgaaata attcaacttc     1680

aaatgaactt accagaatgt tttgcatatc aacaaaaaaa gtggcttgag ttttattata     1740

gttggtgtaa actgaacaca gtgaagacat tggaatttaa taggttctct ctctaaggtg     1800

actcttatac catgcctcta tcaacataat ttgtttagga aagcagtatg aagtttaagc     1860

caaaataatt tctactttat agatgctcaa gagacatttt acaattgaaa atgtctttca     1920

attacaaata ttttgaaact tcgtaagatt ttcattctct gtggtctgtt atatgagaga     1980

gatcctttaa ctagagcaaa gagggagtta gaaacctgat cagggatatt ctttacaagt     2040

tggagcagag gaaagagtag catgccttcg tattttaacg caaatgtctt tttcctcctc     2100

ccaacctact tgagatctga taaggtctgg aagatggaga tatttggtat gcaagtgtag     2160

agttttttaa tcctccagaa tttctagagt agaagatact taggtatagt taaatattct     2220

gtatttttag tcaaacatat ttattaattg aatatagaag aaaatgttga cacactcaga     2280

cagcttactg aattttagat gtcttctgca tcttagaata caagccagtc attcagagtt     2340

ctaaaagtat gcataaaaaa ttacagcacc ggtaggtcta ttaacacagt gcccgagtca     2400

gcggtagcaa gactgatgtg atcataaaac atgacatcag gctcgtctga agttcttgtg     2460

tgaaattcct agtgagtgag gaggctcagc ttaaagccat ctgcagagtg gcccctcatt     2520

gtggtctttt gctgggacca atgcaagaga ctagggagag caaaatgttt gcttatggct     2580

agagactata tccagcccta atgatgggga aagttagtcc ttttcgggta atcttttatg     2640

aattttcacc tgatgaccgt tatattggtc tgttatcatg ttacgataac tgtgatctca     2700

tgaccatgtt gctgtatcag aagaaatagt ttgacaaatg gtaacaacaa cctgatgttc     2760

cccctttaga cctttaactt ctcaaaattt tggtaagttt ccaaattctt taataataac     2820

ttaaaacttt ttgaataact atcaggtcac tttatttgac cacatggtga attcctttaa     2880

tgtcttcagc atttgttaag gaaaagtttt ctctacttgt gtgtgtatgt gtgcacatgt     2940

gtgtatgtac aggtgtatgt atatatctat agatagatac aatacattct ttagacactt     3000

ttcaagattc tttgctgtgg tatattgtgc tcaactcagg tgccaaagga gctttttttt     3060

tttttttttt tttttgagat ggagttttgc tctgtctctc aggctggagt gcagtggcat     3120

gatctcagct cacggcaacc tctgcctccc gggttcaagc aattctcctg tctcagcctc     3180

ctgagtagtt gggattacag gcgcatgcca ccgtgcccag ctaatttttg tatttttagt     3240

agagacgggg tttcaccatg ttggccaggc tggtcacaaa ctcctgactt caagtgatcc     3300

acccgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccactgcg cccccgccca     3360

ggagctcttt tcttatgaca tataaattat gacatttata ttctttatat gactttatgt     3420

tctcttctta tgacatttaa attctttaag tagtttgttg gtccaataaa ctagacgttg     3480

tataatctaa attgagccct tgtatatcta aaactgatga gttgtttcta aattgttgat     3540

tgtccattta cttgcctttg gtattaagat aatgcaagta aagtttagta agtcattgga     3600

taatgaaatg attatgtttc tgaagaccat attatatttt taatttttag aggaatcatg     3660

ccatccccca aaaaatcaag aaatatttga attttaaatt ataagttcat ttgttaaaag     3720

acatttttac aaatgtctga aaatcttaaa atactttaca tctaccttta agtagtagaa     3780

tacagagctg taaatttcca tgcctttttt cctgatatta agttttatag taaaaaagca     3840

actagtgatt gcacaaagaa tataaaaatc cactcttttt acaaaggtgt gaatttaaat     3900

aacgttattg attggaatat gaaaatagac caatcattta agagcttttt agcaaatgat     3960

tcaattctta ctctttttct cccaagattg aaaagcataa tgtatttctc taaagtagga     4020

atctagagag cccctgtgag tggacaaatg tcagtaacac ttgaacacat gagaagataa     4080

gtgttatgtt gtgataattt aaagttaaat ttgctttttg ggtaggatcc ctaaatagat     4140

gggattttta aatagatgat atatagatga caattgcaat tgtcatttta attattttcc     4200

ctacagtaaa gaacctagct ctgagcagtg aaattgtaat ggcactttaa aggaagtaag     4260

ccgttaactg ttctctagtg gagcgatctc caactgtttt ggcactaggg acgggttttg     4320

tggaagaaaa tttttccaca ggactggggg tttaggggga tggtttcagg atgattcaag     4380

tacattacat ttatcattag attctcataa ggagcatgca acctagatct cttgcacgtg     4440

tggttcacag caggattcga gctcctttga gaatctaatg ccatggctga tctaacagga     4500

aactgagctc aggcagtaat gcttggcacc gccccccacc ttctatgcag cccggtcgtg     4560

gcctggggac tggggacccc tgctctagtc agtaataagg tacttgtgcc agaatataaa     4620

tcaacacatt gcttccttta tcaaagaagt cttgttattt aaaaaaagtc aactgagcca     4680

gtatgattag tgatgtaatt gattttcatt ctggcacaag cctctttcat tctggacagc     4740

tcacaaatag ttaatggacc atgctttgaa tagccttcct ctaagcaaca tttataaata     4800

ctgatatttt agaactgttt acatttcttc tgtttatttt tgaattttca gtttgatatc     4860

ttgtccttat tcattgttgt ataaacaact gtactttaat ttcaagtagt attaaaagta     4920

tttcacttca gtttgggggg attattatca atttataatt ttataaaagt attttaaaga     4980

ataattgtaa attttccata aattacaact tcctgccata ttttattaaa taataatctt     5040

gcttaaggca tatagacaga cattattatg agtattccag taaaaaaaat ctacatcaac     5100

ttgaccattc tggctaaaaa ttaaaaagca cttttttata tctgtggttg tcatttgttt     5160

caaagcattt ctaaatttat tgttcttaaa agtatgtctg catgttctag cctttgacct     5220

aggtcatcta tgaaccctct ttgtgtctaa taaacatatc tgtaaaggca tataaatctg     5280

aaaacaa                                                               5287


<210> 427
<211> 4064
<212> DNA
<213> Homo sapiens

<400> 427
gtgctcagcg gcagccacta tggaggccgc caggaccgct gtactccggg tgaagcggaa       60

gcgcagtgcg gagccggcgg aggctcttgt gctcgcttgt aaacgcctcc ggagcgacgc      120

ggtcgagtca gcggcacaga agacgtcgga gggtttggag agagcggcgg agaataatgt      180

cttccacttg gtggccactg tgtgctccca ggaggaacca gtccagcctc tcctgcggga      240

agttctgcgc ccgtcacggg acagccagca gcgtgtccgc cgtaatctcc gcgcctcggc      300

tcgggaggtc cggcaggagg gccgctaccg ggtgctttcc agccgccgat ccttggggac      360

cacctcgagc ggccaggagt ccgagtacac gccggggaac ccagaagccg ccgggaactc      420

gggctttcag ttgttagacc ttgtccacga ggagggagaa cctgaagccg cctctgcagg      480

ctcctgcaaa acatctgacc cagatgtgat cctctgcaat tctgtagagt tgatccgtga      540

gcgattgact gtgtctgagg atggaccagg agtcaggcgc caggaagaac aaaaacacga      600

tgactatgtg tatgacattt actacttgga gacggccact ccaggctgga ttgagaacat      660

cctctccgtg cagccctaca gccaagaatg ggagctggtg aatgatgatc aagaaccaga      720

ggacatttac gacgatgaag atgacgagaa cagtgagaat aactggcgca atgagtaccc      780

agaggaggag agcagtgatg gagatgagga ttccagaggc tctgctgact acaacagcct      840

gagtgaggag gaaagaggca gcagcagaca gcggatgtgg agcaagtacc ctctggatgt      900

gcagaaggag ttcggctatg acagccccca cgacctggat tcagactgat ggtcttgtga      960

tgtccatgag gttctgccac atgcccttga gggctctgag tccagagtta actgccctgc     1020

tgacatcctg ttaggtttcc tagcttaaca tgtggaagga aaagcatatc aagcatatcg     1080

ggcggcacca tcccaccaca gtgaaaactt atgttagggg agtgagtctt ttccacttac     1140

agtaggaccc ctttgcctca atcaaaagtg accctacagt ttgaaagaaa aaaaaacgtt     1200

gaaaaaagga aggtttcttt agctttagct tcttggccca ggaatttttc ctggcattca     1260

ggttctgtgc tgaaaccaca agggaggggg aggttcccat ttcattagca gtaagcttct     1320

gctgtgccat accaccaggc tgcctgcctc taggaaaacc ctgttccttt tgatagaatc     1380

taaaaggggt accagtgggt cccttgtagc aatacagact ggatagtaat ggccattagg     1440

gcagaaagta gtctgagcag tgggagattt tagttaacag ctatttctgc ttccaaactc     1500

tgataacggt tgtgaaatta ctgactgact tcctttggca gtggggccaa gaaacaatat     1560

atatgaatgt gatacatgtg tttagtaaaa tctagctttg aacatggaag aaagtaattc     1620

tttgaaaacc ttttaaatct gaatatctaa aacagggagc ggtagtgaaa tagaaggttc     1680

agcattgatt ataaatacca aggacttaag gcaagggagg aaaaacaaag taccttctga     1740

acttagcttt ccactgagta atgtttactc ttcacagcac ccaccacaaa aacaaactac     1800

tatcaacagg atcaatttta ttaacaactt gtatctcttc taagcagact ctgtccgtat     1860

gcctttccaa accatagctg ccttaactga ctgccttggt gtttattcta gcgtaacatt     1920

gtccagtaga actatctgca gtgatgatat gttctgtgtc tgcactgtgt agtagtagac     1980

acgggtggct gctgagcact tgaaatgtga ttagcgcaac tgagaaactg agcttttaat     2040

tttatttcat tttaatgtaa ttagctacac gtggctagta gctgttgcag cggacaccac     2100

aggtctaagg aaacaacaca gaacattcag ctaggggtgt accctcatag cctgtgagtg     2160

tctcttactc actgtcatgg gggaaggtga gttacacagg gaggtacctt cttgccgcct     2220

cttttaggat ttcctaagta tctctccttc atcctacctg ccatcattct ttgactttat     2280

gtccattttc taaacctttg cctacacttg ctcttatcta catggagttg ttcaacctgc     2340

cgaagtgatt aaattctgtg tacacaggcc gtatatattg cagctaatta aaacaacaaa     2400

catcctaggc atgcacaaag gtataattca ccgttataac aggcagcaac ttgtatgtct     2460

aatattagac atcttgcttt ctgtctgtag gcatagaaac aaaggattga aagccattct     2520

catacagcaa ccgggtgaaa aaaacaaaac actgtgctgt tacaatgtgc tccctgctat     2580

ttatactcat taagtttccc caatattaaa gggctgacaa cttaataaac tgtactcact     2640

gcaaaaggga taataagcac accaggaaaa ggatttaagg agacagacaa caaagagctg     2700

gcagaaatta attccaccat gaagcttgag tgctgtaggg atcctctggc ttcgctccca     2760

aagagaggat cctgggagaa gtctgtatcc agcacagagg ggaaaaatgc tgtcaccatc     2820

caaaaatgaa aggaggatga catggctcac taagcaagta ctagggcacc tggcatgtga     2880

ggtccttgct ttccctagaa gccactggtg gggggcagca aattcctggg attagctggt     2940

tatctggtgg agaaagctaa agctggggtc agggatcttt aaaaggcaag cacattttgc     3000

ttaaaggatt agctccagag gagccctggg atgggtgcca gcttagctca gacagaagtc     3060

atgttcttag cgttcaggca agtcagcctt tgcataagac accctgtcgt cgggcaggaa     3120

tttgccgtta caaatcccaa acccatgaca gtaggaatgt caccccatgc ttcacatatg     3180

cattatgctc tgaacccagg gcaactatga ccatgcttcc ttcaatcttt attgagcaaa     3240

tatatggcca aggttattcc cttatctgtg actgggtgga gaagaatggt caggaaggga     3300

gactgcctca ctgttgacca attccaaaac ctaaggataa gcccatgggg tatgtcaagc     3360

tagcaggttc ttctcggccc aggatgacag tgtctggggg catcacaaaa cagttgtaca     3420

atccaatgca gccgtcctgc tcatacagta agatccatta ggccagagca ggcctaactt     3480

gggtggagag cccagcctga gcaccagaat tagttgcttc cacttgtgca gcctgctgaa     3540

gagccggact caggttgaag cagctttcct cccagtcttc actgatctcc acagggagaa     3600

aacagaagtc cccacaagta ccaagctctt cctgagactg cagccaccac acctcgggga     3660

aggggaggct ggcaggagag gagtacactg tcccggtgac ccacaccaag gtggctccaa     3720

gtgtaaacaa agcctggtgc cagggacaga agaggatgca gcctgatgtg aggttttcag     3780

aaaagtgaaa tgacctagca ccaggttggg attgcttggg tctgcacagc agtccctcac     3840

actgccctta cagagaggaa caggttattt gatgacttgg gcccatgaga tgttctccaa     3900

gccattgaca gctgagagaa ttcaggtgat ccacctgaat atcagaagtt tcagccctct     3960

tagagttcgt aacagaaacc cagagattta ctgtcagcta gaacaaagat gtaaggtctc     4020

aagtaaaata aaggattgtc cttcaaaaca gcaatattaa caga                      4064


<210> 428
<211> 1819
<212> DNA
<213> Homo sapiens

<400> 428
gtgactcctt gatcttcttc ctgcgtggag agccttcgcg ggtgaggctt aacgcgcagg       60

aggtctcacg agagtggaag caactctcgc gaattttaaa atttatcttt ttgcctagcg      120

actgacaaca ggctggttgc ttggcgtgga atcctaaagt ggcctggctt tgagactgga      180

gtgagacccc agccctaggc tggggttctt tccattatag aggagacgga ttcagaaggg      240

ctacagacca aggttgttga aaaccagaca tatgatgagc gtctagagat taacgactcc      300

gaagaggttg caagtattta tactccaacc ccaagacacc aaggacttcc tcgttctgcc      360

catcttccta acaaggctat ggctgataac agcagtgatg agtgtgaaga ggaaaataac      420

aaggtcctaa gggagggcat gccacaggct ccaggccaca gaggcaaaga catggaccct      480

gttccacctg cccctgcaag tctcaagtgc caccagaccc cttctcatgt acttgagagg      540

gtgggatggt acagagagag ccagaagcac agaaaggaga agaagaagac ctcacagttg      600

acacctcaac ggggctttag tgaaaatgag gatgacgatg atgatgatga tgattcatct      660

gaaactgatt ctgattctga tgatgatgat gaagagcatg gagcccctct ggaaggggcc      720

tatgaccctg cagactatga gcatttgcca gtttctgctg aaattaagga actcttccag      780

tacatcagta ggtacacacc tcagttgatt gacctggacc acaaactgaa gcctttcatt      840

cctgatttta tcccagctgt cggggatatt gatgcattct taaaggtccc acgtcctgat      900

ggaaagcctg acaaccttgg cctattggta ttggatgaac cttctacaaa gcagtcagac      960

cctacggtgc tctcactctg gttaacagag aattctaagc agcacaacat cacacaacat     1020

atgaaagtaa aaagcctaga agatgcagaa aagaatccca aagccattga cacgtggatt     1080

gagagcatct ctgaattaca ccgttctaag ccccctgcga ctgtgcacta caccaggccc     1140

atgcccgaca ttgacacgct gatgcaggaa tggtccccgg agtttgaaga gcttttgggc     1200

aaggtaagcc tgcccacggc agagattgat tgcagcctgg cagagtacat tgacatgatc     1260

tgtgccattc tagacatccc tgtctacaag agtcggatcc agtccctcca tctgctcttt     1320

tccctctact cagaattcaa gaactcacag cattttaaag ctctcgctga aggcaagaaa     1380

gcattcactc cttcatccaa ttccacctcc caagctggag acatggagac attaaccttc     1440

agctgagaca cttcccaagc tgctgtttca aggctgagct ggcccctctg ccccagctga     1500

gatggacaga tcgttgtcag ctacttgatg tccttgccca tgccacagct tggctcaggg     1560

gcagtgcatg tcctgctgcc ctctctgcca gagggcacag aacatgtttg tttaatgaac     1620

ctgcctgcct cagattgctg tccccgggga gttaatgcat ctacaccact gtggggattt     1680

gagttataag aattggaatt tctgagatcc catggaggtt agattgggag gaaagcttaa     1740

aagatgtcct ttttgtgaga gggatggaat tgttttcttt cattcgtaaa gttagtgagt     1800

aaagatttta taaatcaaa                                                  1819


<210> 429
<211> 1722
<212> DNA
<213> Homo sapiens

<400> 429
tagacaaaca ggcgacttgg ccgcccagag aggctttatc cgtgactcct tgatcttctt       60

cctgcgtgga gagccttcgc gggtgaggct taacgcgcag gaggtctcac gagagtggaa      120

gcaactctcg cgaattttaa aatttatctt tttgcctagc gactgacaac aggctggttg      180

cttggcgtgg aatcctaaag tggcctggct ttgagactgg agtgagaccc cagccctagg      240

ctggggttct ttccattata gaggagacgg attcagaagg gctacagacc aaggttgttg      300

aaaaccagac atatgatgag cgtctagaga ttaacgactc cgaagaggtt gcaagtattt      360

atactccaac cccaagacac caaggacttc ctcgttctgc ccatcttcct aacaaggcta      420

tggctgataa cagcagtgat gagtgtgaag aggaaaataa caaggagaag aagaagacct      480

cacagttgac acctcaacgg ggctttagtg aaaatgagga tgacgatgat gatgatgatg      540

attcatctga aactgattct gattctgatg atgatgatga agagcatgga gcccctctgg      600

aaggggccta tgaccctgca gactatgagc atttgccagt ttctgctgaa attaaggaac      660

tcttccagta catcagtagg tacacacctc agttgattga cctggaccac aaactgaagc      720

ctttcattcc tgattttatc ccagctgtcg gggatattga tgcattctta aaggtcccac      780

gtcctgatgg aaagcctgac aaccttggcc tattggtatt ggatgaacct tctacaaagc      840

agtcagaccc tacggtgctc tcactctggt taacagagaa ttctaagcag cacaacatca      900

cacaacatat gaaagtaaaa agcctagaag atgcagaaaa gaatcccaaa gccattgaca      960

cgtggattga gagcatctct gaattacacc gttctaagcc ccctgcgact gtgcactaca     1020

ccaggcccat gcccgacatt gacacgctga tgcaggaatg gtccccggag tttgaagagc     1080

ttttgggcaa ggtaagcctg cccacggcag agattgattg cagcctggca gagtacattg     1140

acatgatctg tgccattcta gacatccctg tctacaagag tcggatccag tccctccatc     1200

tgctcttttc cctctactca gaattcaaga actcacagca ttttaaagct ctcgctgaag     1260

gcaagaaagc attcactcct tcatccaatt ccacctccca agctggagac atggagacat     1320

taaccttcag ctgagacact tcccaagctg ctgtttcaag gctgagctgg cccctctgcc     1380

ccagctgaga tggacagatc gttgtcagct acttgatgtc cttgcccatg ccacagcttg     1440

gctcaggggc agtgcatgtc ctgctgccct ctctgccaga gggcacagaa catgtttgtt     1500

taatgaacct gcctgcctca gattgctgtc cccggggagt taatgcatct acaccactgt     1560

ggggatttga gttataagaa ttggaatttc tgagatccca tggaggttag attgggagga     1620

aagcttaaaa gatgtccttt ttgtgagagg gatggaattg ttttctttca ttcgtaaagt     1680

tagtgagtaa agattttata aatcaaatgc tctattatat tg                        1722


<210> 430
<211> 2286
<212> DNA
<213> Homo sapiens

<400> 430
cgcagggacc gtgctccgcc gtctccgccg catcttccac cctcgccgcc gccgcagctc       60

cccgcgctcg tgccaccgcc gccgcgtcca ccctcagcgc caccgccatg cgggagatcg      120

tgcacctgca ggccggccag tgcggcaacc agatcggggc caagttttgg gaggttatca      180

gtgacgaaca tggcatcgac cccacaggca cataccatgg ggacagtgac ctgcaactgg      240

agaggatcaa cgtgtactac aacgaggcca caggaggaaa ttatgtcccc agagcggtgc      300

tggtggacct ggaacccggc accatggact ctgtccgttc tggccccttc ggtcagatct      360

ttcggccgga caacttcgtg tttggccaat ccggagccgg caacaactgg gcaaaggggc      420

actacacgga gggcgcagag ctggtggacg ctgtcctgga cgtagtccgg aaggaggccg      480

agagctgcga ctgccttcag ggcttccagc tgacccactc gctggggggt ggcacggggt      540

ccggaatggg cacgctgctc atcagtaaga tccgcgagga gttcccagac cgcatcatga      600

acaccttcag cgtggtgccc tcgcccaaag tgtcagacac ggtggtggag ccctacaacg      660

ccacgctgtc tgtgcaccag ctggtggaga atacggatga gacctactgc atcgacaacg      720

aggcactcta cgacatctgt ttccgcaccc tcaagctgac cacccccacc tacggggacc      780

tcaaccacct ggtgtcggcc accatgagcg gggtcaccac ctgcctgcgc ttcccgggcc      840

agctgaacgc cgacctgcgc aagctggccg tcaacatggt tccctttcct cgcctgcact      900

tcttcatgcc cggcttcgca cccctgacca gccggggcag ccagcagtac cgggccctga      960

cggtgcccga gctcacccag cagatgttcg atgccaagaa catgatggcg gcgtgcgacc     1020

cgcgccacgg ccgctacctg accgtggccg ccgtgttccg gggccgcatg tccatgaagg     1080

aggtggacga gcagatgctg agcgtgcaga gcaagaacag cagctacttc gtggagtgga     1140

tccccaacaa cgtgaagacg gccgtgtgcg acatcccgcc ccgcggcctg aagatggccg     1200

cgaccttcat cggcaacagc acggccatcc aggagctgtt caagcgcatc tccgagcagt     1260

tcacggccat gttccggcgc aaggccttct tgcactggta cacgggcgag ggcatggacg     1320

agatggagtt caccgaggcc gagagcaaca tgaatgacct ggtatctgag taccagcagt     1380

accaggacgc cacggccgag gagggcgagt tcgaggagga ggcggaggag gaggtggcct     1440

aggctgctcc catcgcttcc cacctgtccc ctcgaggctt ctgacctttg atccgctagg     1500

ccccccatct ctgaacccta gagccccgct ttccctccaa ggctgactcc ccgctgaccc     1560

taacaatacc tttggagctc gctttacctc tggctacttc atctccgacc ctggctcccc     1620

tttgagccct aatttatctt taaccccctt gagctcttcc aaccttgaca ttcccaggag     1680

gagccccgct tcaccccttc tgactctgga aaccgcacct ttaactttgc agaccttcct     1740

tcacccctga cttctgcttc acctttgacc tctgcccccc atgaatccca ttttacctct     1800

agacctataa gttctggttt atgtttgacc cctccctctg agctgcactt caccgctgac     1860

cttgcctcac ctttaacccc ccacctgagc cccagctcct acctctgacc ccaacttctc     1920

tttgatctct gaatcccctc tgactccaac ttctctttca ccctctatga gtcccatttt     1980

acttctacac ctgcaagtcc tggtttatat tggacccctc cctccgagct gcagttcacc     2040

tttgaccttg cctcaccttt caccccccac cccccacagc gtcagctcct acctctgacc     2100

ccagcttctc tctgattccc acaggcccca tgcatcctcc ctgcctcact cccctcagcc     2160

cctgccgacc ttagcttatc tgggagagaa acaaggcctg gtgcctgtga ggaagagagg     2220

tcacccctac cctccctccc cgcttccctg cctcaccctc aataaataaa ttaattgttg     2280

tcatgg                                                                2286


<210> 431
<211> 1805
<212> DNA
<213> Homo sapiens

<400> 431
tggcatttga aatggtgggc aggagcacat gttgcttaaa tttctgacag tggctggaga       60

ttaccgattg gttaggggag aggaagtaaa gtaaaatatt tataaattct ccactgggtg      120

gagtctgagc agttctttga atttctcacc ctaagatctg gcctgtacat tttcaaggaa      180

ttcttgagag gttcttggag agattctggg agccaaacac tccattggga tcctagctgt      240

tttagagaac aacttgtaat ggagccttca tctcttgagc tgccggctga cacagtgcag      300

cgcattgcgg ctgaactcaa atgccaccca acggatgaga gggtggctct ccacctagat      360

gaggaagata agctgaggca cttcagggag tgcttttata ttcccaaaat acaggatctg      420

cctccagttg atttatcatt agtgaataaa gatgaaaatg ccatctattt cttgggaaat      480

tctcttggcc ttcaaccaaa aatggttaaa acatatcttg aagaagaact agataagtgg      540

gccaaaatag cagcctatgg tcatgaagtg gggaagcgtc cttggattac aggagatgag      600

agtattgtag gccttatgaa ggacattgta ggagccaatg agaaagaaat agccctaatg      660

aatgctttga ctgtaaattt acatcttcta atgttatcat tttttaagcc tacgccaaaa      720

cgatataaaa ttcttctaga agccaaagcc ttcccttctg atcattatgc tattgagtca      780

caactacaac ttcacggact taacattgaa gaaagtatgc ggatgataaa gccaagagag      840

ggggaagaaa ccttaagaat agaggatatc cttgaagtaa ttgagaagga aggagactca      900

attgcagtga tcctgttcag tggggtgcat ttttacactg gacagcactt taatattcct      960

gccatcacaa aagctggaca agcgaagggt tgttatgttg gctttgatct agcacatgca     1020

gttggaaatg ttgaactcta cttacatgac tggggagttg attttgcctg ctggtgttcc     1080

tacaagtatt taaatgcagg agcaggagga attgctggtg ccttcattca tgaaaagcat     1140

gcccatacga ttaaacctgc attagtggga tggtttggcc atgaactcag caccagattt     1200

aagatggata acaaactgca gttaatccct ggggtctgtg gattccgaat ttcaaatcct     1260

cccattttgt tggtctgttc cttgcatgct agtttagaga tctttaagca agcgacaatg     1320

aaggcattgc ggaaaaaatc tgttttgcta actggctatc tggaatacct gatcaagcat     1380

aactatggca aagataaagc agcaaccaag aaaccagttg tgaacataat tactccgtct     1440

catgtagagg agcgggggtg ccagctaaca ataacatttt ctgttccaaa caaagatgtt     1500

ttccaagaac tagaaaaaag aggagtggtt tgtgacaagc ggaatccaaa tggcattcga     1560

gtggctccag ttcctctcta taattctttc catgatgttt ataaatttac caatctgctc     1620

acttctatac ttgactctgc agaaacaaaa aattagcagt gttttctaga acaacttaag     1680

caaattatac tgaaagctgc tgtggttatt tcagtattat tcgattttta attattgaaa     1740

gtatgtcacc attgaccaca tgtaactaac aataaataat ataccttaca gaaaatctga     1800

tataa                                                                 1805


<210> 432
<211> 5793
<212> DNA
<213> Homo sapiens

<400> 432
gtaacacaag tggcaagaca gccgggaacc cctaccccat ccccttattc agcacatgaa       60

ataaacaagg ggcatccaaa tcttgcggca acgcccccgg gacatgcatc gtcccctgga      120

ctctctcaaa ccccttatcc ctctggacag aatgcaggtc caaccacgct ggtataccct      180

caaacccctc agacaatgaa ttcacaacct caaacccgtt ctccgttttt ccagaggcct      240

caaatacagc ctcctagagc taccatcccg aacagcagtc cttccattcg tcctggtgca      300

cagacaccca ctgcagtgta ccaggctaat cagcacatca tgatggttaa ccatctgccc      360

atgccgtacc cagtgcccca ggggcctcag tactgtatac cacagtaccg tcatagtggc      420

cctccttatg ttgggccccc ccaacaatat ccagttcaac caccggggcc aggtcctttt      480

tatcctggac caggacctgg ggacttcccc aatgcttatg gaacgccttt ttacccaagt      540

cagccggtgt atcagtcagc acctatcata gtgcctacgc agcaacagcc gcctccagcc      600

aagagagaga aaaaaactat aagaattcgg gatccaaacc agggaggtaa agacataaca      660

gaggagatta tgtctggagg tggcagcaga aatcctactc cacccatagg aagacccacg      720

tccacaccta ctcctcctca gcagctgccc agccaggtcc ccgagcacag ccctgtggtt      780

tatgggactg tggagagcgc tcatcttgct gccagcaccc ctgtcactgc agctagcgac      840

cagaagcaag aggagaagcc aaaaccagat ccagtgttaa agtctccttc cccagtcctt      900

aggctagtcc tcagtggaga gaagaaagaa caagaaggcc agacatctga aactactgca      960

atagtatcca tagcagagct tcctctgcct ccatcaccta ccactgtttc ttctgttgct     1020

cgaagtacaa ttgcagcccc cacctcttct gctcttagta gccaaccaat attcaccact     1080

gctatagatg acagatgtga actctcatcc ccaagagaag acacaattcc tatacccagc     1140

ctcacatctt gcacagaaac atcagaccct ttaccaacaa atgaaaatga tgatgatata     1200

tgcaagaaac cctgtagtgt agcacctaat gatattccac tggtttctag tactaaccta     1260

attaatgaaa taaatggagt tagcgaaaaa ttatcagcca cggagagcat tgtggaaata     1320

gtaaaacagg aagtattgcc attgactctt gaattggaga ttctcgaaaa tcccccagaa     1380

gaaatgaaac tggagtgtat cccagctccc atcacccctt ccacagttcc ttcctttcct     1440

ccaactcctc caactcctcc agcttctcct cctcacactc cagtcattgt tcctgctgct     1500

gccactactg ttagttctcc gagtgctgcc atcacagtcc agagagtcct agaggaggac     1560

gagagcataa gaacttgcct tagtgaagat gcaaaagaga ttcagaacaa aatagaggta     1620

gaagcagatg ggcaaacaga agagattttg gattctcaaa acttaaattc aagaaggagc     1680

cctgtcccag ctcaaatagc tataactgta ccaaagacat ggaagaaacc aaaagatcgg     1740

acccgaacca ctgaagagat gttagaggca gaattggagc ttaaagctga agaggagctt     1800

tccattgaca aagtacttga atctgaacaa gataaaatga gccaggggtt tcatcctgaa     1860

agagacccct ctgacctaaa aaaagtgaaa gctgtggaag aaaatggaga agaagctgag     1920

ccagtacgta atggtgctga gagtgtttct gagggtgaag gaatagatgc taattcaggc     1980

tccacagata gttctggtga tggggttaca tttccattta aaccagaatc ctggaagcct     2040

actgatactg aaggtaagaa gcagtatgac agggagtttc tgctggactt ccagttcatg     2100

cctgcctgta tacaaaaacc agagggcctg cctcctatca gtgatgtggt tcttgacaag     2160

atcaaccaac ccaaattgcc aatgcgaact ctggatcctc gaattttgcc tcgaggacca     2220

gactttacac cagcctttgc tgattttgga aggcagacac ctggtggaag aggcgtacct     2280

ttgttgaatg ttgggtcacg aagatctcaa cctggccaaa gaagagaacc cagaaagatc     2340

atcacagttt ctgtaaaaga agatgtacac ctgaaaaagg cagaaaatgc ctggaagcca     2400

agccaaaaac gagacagcca agccgatgat cccgaaaaca ttaaaaccca ggagcttttt     2460

agaaaagttc gaagtatctt aaataaattg acaccacaga tgttcaatca actgatgaag     2520

caagtgtcag gacttactgt tgacacagag gagcggctga aaggagttat tgacctggtc     2580

tttgagaagg ctattgatga acccagtttc tctgtggctt acgcaaacat gtgtcgatgt     2640

ctagtaacgc tgaaagtacc catggcagac aagcctggta acacagtgaa tttccggaag     2700

ctgctactga accgttgcca gaaggagttt gaaaaagata aagcagatga tgatgtcttt     2760

gagaagaagc agaaagaact tgaggctgcc agtgctccag aggagaggac aaggcttcat     2820

gatgaactgg aagaagccaa ggacaaagcc cggcggagat ccattggcaa catcaagttt     2880

attggagaac tctttaaact caaaatgctg actgaagcca tcatgcatga ctgtgtggtg     2940

aagctgctaa agaaccatga tgaagaatcc ctggagtgcc tgtgtcgcct gctcaccacc     3000

attggcaaag acttggactt tgaaaaagca aagccacgta tggaccagta ctttaatcag     3060

atggagaaaa ttgtgaaaga aagaaaaacc tcatctagga ttcggttcat gcttcaagat     3120

gttatagacc taaggctgtg caattgggta tctcgaagag cagatcaagg gcctaaaact     3180

atcgaacaga ttcacaaaga ggctaaaata gaagaacaag aagagcaaag gaaggtccag     3240

caactcatga ccaaagagaa gagaagacca ggtgtccaga gagtggacga aggtgggtgg     3300

aacactgtac aaggggccaa gaacagtcgg gtactggacc cctcaaaatt cctaaaaatc     3360

actaagccta caattgatga aaaaattcag ctggtaccta aagcacagct aggcagctgg     3420

ggaaaaggca gcagtggtgg agcaaaggca agtgagactg atgccttacg gtcaagtgct     3480

tccagtttaa acagattctc tgccctgcaa cctccagcac cctcagggtc cacgccatcc     3540

acgcctgtag agtttgattc ccgaaggacc ttaactagtc gtggaagtat gggcagggag     3600

aagaatgaca agccccttcc atctgcaaca gctcggccaa atactttcat gaggggtggc     3660

agcagtaaag acctgctaga caatcagtct caagaagagc agcggagaga gatgctggag     3720

accgtgaagc agctcacagg aggtgtggat gtggagagga acagcactga ggctgagcga     3780

aataaaacaa gggagtcagc aaaaccagaa atttcagcaa tgtcagctca tgacaaggct     3840

gcattatcag aagaggaact ggagaggaag tcgaaatcta tcattgatga atttctacac     3900

attaatgatt ttaaggaagc catgcagtgt gtggaagagc tgaatgccca gggcctacta     3960

catgtttttg tgagagtggg agtggagtcc accctggaaa ggagccagat caccagggat     4020

cacatgggcc aattactcta tcagctggta cagtcagaaa aactcagcaa acaggacttt     4080

ttcaaaggtt tttcagaaac tttggaattg gcagatgaca tggccattga tattccccat     4140

atttggttgt accttgctga actggtgacc cccatgttaa aagaaggtgg aatctccatg     4200

agagaactta ccatagaatt tagcaaacct ttacttcctg ttggaagagc tggggtcttg     4260

ctatctgaaa tattgcacct actatgcaaa caaatgagcc ataagaaagt gggagcctta     4320

tggagggagg ctgacctcag ctggaaggac tttttaccag aaggagaaga tgtacataat     4380

tttcttttgg agcagaagtt ggacttcata gagtctgaca gtccctgttc ctctgaagca     4440

ctttcaaaga aagaactgtc tgccgaagag ctgtataagc gactcgagaa actcattatt     4500

gaggacaaag cgaatgatga acagatcttt gactgggtag aggctaatct agacgaaatc     4560

cagatgagtt cacctacatt ccttagagct ttaatgactg ctgtttgtaa agcagctatt     4620

atagccgact cttctacctt cagagtggac actgctgtta tcaagcagag agtgccgatc     4680

ttactcaagt acctagactc agatacagag aaggaactgc aagcacttta tgcactacaa     4740

gcatcgatag taaaacttga tcaacctgcc aatttgctgc ggatgttttt tgattgtcta     4800

tatgacgagg aggtgatctc cgaggatgcc ttctacaaat gggagagcag caaggaccct     4860

gcagagcaga atgggaaggg cgtggctctg aaatctgtca cggcattctt cacgtggctg     4920

cgggaagcag aagaggagtc tgaggataac taaaacttca aatacacaaa atgaaacaaa     4980

agaaacaatt taagtatttt tttaaaaagt ttcacgtctt cgccaatcac agtgcagcaa     5040

ggccaattct cgcagaaacc cccacgtgtg cacgagtggg agaggggaaa gagaaaaaaa     5100

ggtgatcatg gaggaaaaag gtactggata aaagtaaact tcaaacctta gggcgggagc     5160

actaaaacca aaatacatgt attatttata gaaaatattt tctgttttaa tcttttcttt     5220

ttaaacaagg actcatactt aaaaaaatgt ttagcaaaaa aaaaaaaagt tgagaacttt     5280

taatttattt taaggactgc aaatgccagt gtaatttttt aatttgcagt ttctgtaaac     5340

aacttgtata atagaaaagc agagaaataa atttccctcc ccttcaagat gcacctcatg     5400

tttgttttaa ggtatagcat ttagtccaga tttgagaaag tttggggtga acaaggtaag     5460

aaagattttt ttttttttgg catcaaatct ttctgcctgc ctctcagctt gcttcagaaa     5520

atttaaaaaa tcacaatagt aatcaaaaca tacataacat tgaaacagaa ggaaatgctg     5580

tggaccacag aactccaaga attgtttaaa aaaaaaaaag tgctaccctg agaaaagtac     5640

tcttaatact cttgaaatct ttagagcaac tttaaggctt gtaaatacat agaacaaata     5700

tttaaaaaaa caaaaagaaa ttgactcagt actatttctt ttcactttga aaatataaag     5760

aacaaaataa agacaaacat tgcaagttta aaa                                  5793


<210> 433
<211> 1865
<212> DNA
<213> Homo sapiens

<400> 433
ctcagatctc cctgtcgtgt catctcacat ctgtcatctc tcaggtcata tccaacacac       60

tgggccaccc acgcacaggg acgacgcgac agccctgtgg ctccaccgca caggacagcc      120

acgactggca atcctgtgcc ggccctgctc gacgcaagca cctccagcgc cgggttgcgt      180

cttagtgacc ctgggaccgc cagccaggca ccgcgcccga cgcaggctca gtcagtgttg      240

gtcggatgca tgaatgaatg ggaaaaacga agtctctctc tccctggccc tgctcccata      300

catctgtagg cctaggtctt ggttttatcc gaagacttag agaagggacg caagttcctt      360

cgcggagcca gaaggaatcc gtcgagaagc gggacctcaa gctcgcggcc caaaagcgcg      420

gccccgccac gacgcctgct agctggcccc acttcggcgc gcgccgctta catcatagct      480

cgcctctccc cttccctagc cacaccccct tgcctggcga cccggaagtt gtacttgcaa      540

ctgcggcttt ccttctccca caatccttcg cgctcttcct ttccaacttg gacgctgcag      600

aatggctccc gcaaagaagg gtggcgagaa gaaaaagggc cgttctgcca tcaacgaagt      660

ggtaacccga gaatacacca tcaacattca caagcgcatc catggagtgg gcttcaagaa      720

gcgtgcacct cgggcactca aagagattcg gaaatttgcc atgaaggaga tgggaactcc      780

agatgtgcgc attgacacca ggctcaacaa agctgtctgg gccaaaggaa taaggaatgt      840

gccataccga atccgtgtgc ggctgtccag aaaacgtaat gaggatgaag attcaccaaa      900

taagctatat actttggtta cctatgtacc tgttaccact ttcaaaaatc tacagacagt      960

caatgtggat gagaactaat cgctgatcgt cagatcaaat aaagttataa aattgccttc     1020

atgtttttgt tctttttagt tgcaacataa tgtacttgta taccctatcc taattatggg     1080

atcatttgaa gagcttttcc caaattgatg gcctgtgctg ccttctcccc atcccctggg     1140

gttttaaagt gatttcaaac tgcaacctag ttttagaacc actgttctgg gtagttggga     1200

tactgaaggc atattgttaa ttattctact tgtatgtttt gctaattcta agataagcat     1260

ttttccagaa accaggatgt agaatccagt tgccattgac atcttaacat tttaggaaac     1320

aactttaaaa tgatatacta tctatctatc tatctgtagc atcttaaagg taatgaaatt     1380

aatgtggcag taggtctttt aagcttctgc ctacatccat attgagtata gttgttgtct     1440

tctaaaataa ttaattgatt tttggtgaga taaccagatt catattttaa gccttttgta     1500

atggccccgt ggtacctgga gtcaaggttc agaagtaaaa agttccttaa ggtatcaata     1560

acaaaaattt gtattaatag ttcagtccta aagcagtgtt gctgagatta tgtttcacca     1620

gcatttacaa gctgtatgtt aaatgctgcc ataaagaggt ctctgaagcc gtagggcaca     1680

cccaaggcag ggctgagaag tacctagtag tgttgcacca cccaaaaacc atggatgggc     1740

agcagcaaca tctccagctt acccattcac tgccacagtc tacagcttaa gacacttaac     1800

tacaaggtaa aagaaaagga ccaagtaaat acaaaaagtt tcttattaaa aaacttggaa     1860

gccaa                                                                 1865


<210> 434
<211> 2046
<212> DNA
<213> Homo sapiens

<400> 434
gttgctatcc cagaatcctc agagaaggag tagcgcgttc gtgcgtccta gttccagtac       60

agcgtggagg gtttaggcag cgtgttctga ttctttgcgg gacggcgagc gcatttgtgc      120

tttgcccgcc gcggcctagg aggccttttg aggccgcgta gtcggtgttt ttgaactgac      180

tctacagctt ctggcaggcc gtgcggcgcc ctgacccggc ctcaccatgt tggtgctgtt      240

tgaaacgtct gtgggttacg ccatctttaa ggttctaaat gagaagaaac ttcaagaggt      300

tgatagttta tggaaagaat ttgaaactcc agagaaagca aacaaaatag taaagctaaa      360

acattttgag aaatttcagg atacagcaga agcattagca gcattcacag ctctgatgga      420

gggcaaaatc aataagcagc tgaaaaaagt tctgaagaaa atagtaaaag aagcccatga      480

accgctggca gtagctgatg ctaaactagg aggggtcata aaggaaaagc tgaatctcag      540

ttgtatccat agtcctgttg ttaatgaact tatgagagga attcgttcac aaatggatgg      600

attaatccct ggggtagaac cacgtgaaat ggcagctatg tgtcttggat tggctcacag      660

cctgtctcga tatagattga agtttagcgc tgataaagta gacacaatga ttgttcaggc      720

aatttccttg ttagatgact tggataaaga actaaacaac tacattatgc gatgtagaga      780

atggtatggc tggcatttcc ctgaattagg aaaaattatt tcagataatt taacatactg      840

caagtgttta cagaaagttg gcgataggaa gaactatgcc tctgccaagc tttctgagtt      900

gctgccagaa gaagttgaag cagaagtgaa agcagctgca gagatatcaa tgggaacaga      960

ggtttcagaa gaagatattt gcaatattct gcatctttgc acccaggtga ttgaaatctc     1020

tgaatatcga acccagctct atgaatatct acaaaatcga atgatggcca ttgcacccaa     1080

tgttacagtc atggttgggg aattagttgg agcacggctt attgctcatg caggttctct     1140

tttaaatttg gccaagcatg cagcttctac cgttcagatt cttggagctg aaaaggcact     1200

tttcagagcc ctcaaatcta gacgggatac ccctaagtat ggtctcattt atcatgcttc     1260

actcgtgggc cagacaagtc ccaaacacaa aggaaagatt tctcgaatgc tggcagccaa     1320

aaccgttttg gctatccgtt atgatgcttt tggtgaggat tcaagttctg caatgggagt     1380

tgagaacaga gccaaattag aggccaggtt gagaactttg gaagacagag ggataagaaa     1440

aataagtgga acaggaaaag cattagcaaa aacagaaaaa tatgaacaca aaagtgaagt     1500

gaagacttac gatccttctg gtgactccac acttccaacc tgttctaaaa aacgcaaaat     1560

agaacaggta gataaagagg atgaaattac tgaaaagaaa gccaaaaaag ccaagattaa     1620

agttaaagtt gaagaagagg aagaagaaaa agtggcagaa gaagaagaaa catctgtgaa     1680

gaagaagaag aaaaggggta aaaagaaaca cattaaggaa gaaccacttt ctgaggaaga     1740

accatgtacc agcacagcaa ttgctagtcc agagaaaaag aagaaaaaga aaaaaaagag     1800

agagaacgag gattaacaga aaggaattac gattatatca cccggacaca catcatgctt     1860

aagattcaac tgggagcata ccagggatgc tctctaacgt aatcaaggga aggttcagta     1920

agacaaagtg atttatcatc tataacttca aacctatttg tcttgacatc aactctgtta     1980

accttatgtc atcatttctt agagtctttg atatacaaat aaaattttct ttgtatttta     2040

agacaa                                                                2046


<210> 435
<211> 1414
<212> DNA
<213> Homo sapiens

<400> 435
tgcctccggg tcgcggtcat tttgagcccc tgtctggatg acttcttgcg gctgttctac       60

ccctccccct ccccgcggta ccttgcactt ttctccctcc ctgccccctc tcgagtccac      120

cctccgggcc ttctgcccct gatcgcttgg ttttccttgc agtcgcctgc tgctgtcgtc      180

gggaggaaag atgaatggga gggctgattt tcgagagccg aatgcagagg ttccaagacc      240

aattccccac atagggcctg attacattcc aacagaggaa gaaaggagag tcttcgcaga      300

atgcaatgat gaaagcttct ggttcagatc tgtgcctttg gctgcaacaa gtatgttgat      360

tactcaagga ttaattagta aaggaatact ttcaagtcat cccaaatatg gttccatccc      420

taaacttata cttgcttgta tcatgggata ctttgctgga aaactttctt atgtgaaaac      480

ttgccaagag aaattcaaga aacttgaaaa ttcccccctt ggagaagctt tacgatcagg      540

acaagcacga cgatcttcac cacctgggca ctattatcaa aagtcaaaat atgactcaag      600

tgtgagtggt caatcatctt ttgtgacatc cccagcagca gacaacatag aaatgcttcc      660

tcattatgag ccaattccat tcagttcttc tatgaatgaa tctgctccca ctggtattac      720

tgatcatatt gtccaaggac ctgatcccaa ccttgaagaa agtcctaaaa gaaaaaatat      780

tacatatgag gaattaagga ataagaacag agagtcatat gaagtatctt taacacaaaa      840

gactgacccc tcagtcaggc ctatgcatga aagagtgcca aaaaaagaag tcaaagtaaa      900

caagtatgga gatacttggg atgagtgaaa aattacatca ttggacatga aggagtttca      960

acatccagct tcatctaggt ggtcatgatt acctgcatgc tttgagctca gcagcagtct     1020

tcataaacac atttaaaaca agatcctggg tttttgtggt ttgacttcta tggtgtttta     1080

aaaaaacaca gatttttagt gttaatattg tgtaaatgta ctcaccttag ggattcattt     1140

gaatgatggt attataccat gattgtatac agtttgtgaa attgttgcaa gggcaaagat     1200

aactcttaaa aaaccgtcga gattacaatg ctctagaatc agcatataag aaaataaatg     1260

atatctgcat gttgaattgg ggtggatggg gggagcaagc ataattttta agtgtgaagc     1320

tttgcatcaa gaaattatta aaaagctttt tttctccagt attttctgta ttatcttaat     1380

gtttatggca aataaaatgt aaaggaacat gcaa                                 1414


<210> 436
<211> 6146
<212> DNA
<213> Homo sapiens

<400> 436
aatccccgcc cctcaagcac cggccccgcc ccataggccc cgtccgtggc cccgccccgc       60

cgcgagctgg cgccgggtcc tctcagcgcc cgccggcggc cgcgtccacc cccgacgctc      120

tgaggtcacc gactgggccg gcccgcgggg ggcggaggga cggagggaag atggcggcag      180

gggccggata ttggcgccgc ctcccccaat cccggagccg gcgcagatga ggcagttcgg      240

ctggggccag cggcgctttg gaacccgagg tggggggacc ctggcggtgg ggcctggtcc      300

tgctatatgc cggcgcctcg gctagagtga gcggcggcga cgcctctttc ctccgtctct      360

ttccctgtcg ctgcgagagc gagcgggcgg cggaggcggc ggcggcggcg gggccgggat      420

ggaggacgtt aactccaacg tgaacgcgga ccaggaggtg cggaagctgc aggagctggt      480

gaagaagctg gagaagcaga acgaacagct gaggagccgc tcgggggccg tgcagggcgc      540

cggctccctt gggcccggca gcccggttcg ggccggcgcg tccattccct cctccggcgc      600

ggcgtctcct cggggcttcc ccttgggcct cagcgccaag tcgggcggcg ggcccgggtc      660

gggcccgagg cggacgagta gcgaagagct gcgggacgcc acctccttgc tagcggcggg      720

cgagggcggc ttgctggacg aggtggagcc gctgcggccc gacgagctgg agcgcctgtc      780

aggctgggag gaggaggagg agagctggct gtattcatca ccaaagaaaa aacttacacc      840

aatgcagaaa tcggttagtc cattagtttg gtgcaggcaa gttttggatt acccaagtcc      900

tgatgttgag tgtgctaaaa aatctcttat ccacaaactt gatcaaacta tgtcagctct      960

caagaggcag aatttatata ataatccttt caactctatg agttacacca gtccttacag     1020

tccaaatgcc agtagcccat acagcagtgg cttcaattct ccatcctcaa ccccagtgcg     1080

acctcctata gtcaaacagc ttatacttcc tggaaattca ggtaacttga aaagctcaga     1140

cagaaatcct ccactcagtc ctcagtcctc tatagatagt gagttaagtg cttcagaatt     1200

agatgaagat tcaattggat ccaattataa gctaaatgat gtaactgatg tacagattct     1260

agcccggatg caggaagaaa gtctccggca agaatatgca gccaccacgt ctcggcgcag     1320

ttctggttca tcttgcaatt ctacaagacg gggtactttt agtgatcagg aacttgatgc     1380

acaaagttta gatgatgaag atgacaatat gcatcatgca gtataccctg ctgttaacag     1440

gttttcacca tcaccacgca attcacctcg accgtcacct aagcagtcac ccagaaattc     1500

acctcgttca cgatctcctg ctcggggaat agaatatagt agagtgtccc cacagcctat     1560

gattagccgc ttacagcaac ctcgcctttc acttcaaggc catcccacag atttacagac     1620

aagcaatgtt aaaaatgaag aaaaactaag acgcagtctt ccaaacctgt cccgaacatc     1680

taatacacaa gttgactcag tgaaaagcag cagaagtgac tcaaattttc aagtgccaaa     1740

cggaggaata cctcgtatgc aacctcaggc ttcagccata ccttctccag gcaaattccg     1800

ttcccctgca gcaccatctc ctttggctct tcggcaacca gtgaaagcat ttagtaacca     1860

tggctctggt tctcctggta gccaagaaat aacacagctc acacaaacca cctcctcacc     1920

tgggcctcct atggttcaga gcacagtctc agcaaatcct cccagcaata tcaacagcgc     1980

tactctaacc agacctgcag ggacaactgc aatgagaagt ggcttgccca gacccagtgc     2040

cccttctgct gggggcatac cagtgcctcg cagcaaactt gcacagcctg ttcgcagatc     2100

cttgccagct cctaaaacct atggtagcat gaaagatgac agttggaaag atggctgtta     2160

ctgaccagca aagacaagaa tgcagaagtc cacggcttca tggataccct tcaccaggct     2220

aaaaaacaac ttttatatgc agactgttca gataagactc ttgggattta taaaatccca     2280

gccctctctg tcttaattag cacaaaccga cagagatcat caaacagcac tttaatgaca     2340

tttaacatca gatgtgtttg gtaatcatac aatcactctc catagaatca cttttagttt     2400

tgtttaatag aaactaggtt gatttttaaa aaatatttga cagaggccaa tatctgggca     2460

aatacctaat ggatgccaaa gagaaatgcc catttgtaaa tgagaaaaat gcccatttgt     2520

gcacaagaaa atggtgaatt caggctatcc aaaacttcac attcaaccta atttactgta     2580

taaatagtat caataaatat ttgtgttaat gagaactaat attctgacta attatctaaa     2640

gtgtttcact agtacaccag gaaactacag attgagatta gggggtggga ggaaagaaac     2700

ctgggctaga gattaaaaca ttcctaaatt tagcagaatt tcagaaatga tttttgcaga     2760

ttcattagaa aagaaaaatt gtcatttaat cttaagtttt ggatgtagct cacatgtcac     2820

caccaccaga tagtgttaca gcatgtatcc atcatgttgc attgacacat caaacttgtg     2880

tgtgtttgtt ttgattgcca aaagggctta atatcagttg tacaatcttt ctgaacttta     2940

tagttcctgg ctcaggaaag atggcctttg ctattgaagc caacttcttc acatgctgtt     3000

atctttacag aactaagaga tcttgtttct attagcaggt tttcatgata ggaaagaaca     3060

agtagtgtgt gtctttattc ttgatacaac accacctcgg tgcttgcaac ctggaacaaa     3120

accataccat gagagagagg gggaaaaaaa tctatgcact taacctacaa aatctctggt     3180

gatgacagtt gtattgttgc tattacatgg cataacggtc tattatgtgg taggaaaata     3240

tagcctgcta aatcctactt aagttgatcc actttaaact gagtaactgt ataaaacatc     3300

tattgaaaat tcttttcctt ttgacttaga ttctgcctta catcaatttt tgcatttttg     3360

gtaaaaaaaa aaccctacta cgtatgactc taacctgata cttgctctct aatggctctt     3420

aatatatcct tgaaatcggc tatttcaatt ttatcagact tttaccagag taaaacttgc     3480

ttctgtagca ggcctctcat tttttattat gaggtctgtt tttaaatact taatttgaac     3540

agctctaaga tattgtcact taggtcatct aaaagctttt agagatttga acataagttc     3600

atttcctgtt aatcaaagac attccgtaag ttggcaaaag aaattgggag agagaaatag     3660

aaggcttgat attctggaca gcattaaggt tgataggttg atgataaaaa cttaaaacca     3720

ggacctccat tctgtcatga ctgacaccat ggtagtctgt cagcttgacc agtggagagt     3780

cattcattta gcacaagcag ctggagattt aaactgccag tactatgtat ttggtgtata     3840

atgcaaggaa gaaactttat ccttgaattt gagggtgatg gggtgggtca ggaaaggatg     3900

gcgccagaat tctacatgat aatgaactaa aaaatgttgc ttttcagagg aagataaagc     3960

atcttctttt gggagggggg tatctcatgt ctaagtaagt aaaagaaaga agtagctact     4020

gtctctttta aaaaccacgt acaaaacaga acaagtctca gttttcagtg caacatttca     4080

aaaaatatat atgctgcaat ctaataatta aaaggaattt tacctattat gaaacatatt     4140

acatttttta agttagataa tcagtttcaa aaggagtatt caggttattt aactttgttt     4200

ttaaatggct gcatcagaaa aaaatgtcta ttttttttta ttaaaatatt tcatcacttg     4260

ttaaaacata tttttgatct gagtttggta aagtattatt ttacctgctg ttgtactacc     4320

acagactgtt gacttttagt ttcttaaaga gaaaaattgc ctttttacta gaaagccttt     4380

gtatattgca atttttctgt ttgggaaaat ctaaggattt actgtggtta gtcttacaga     4440

agaaatgtgg atttgataaa ctagtgccta tgattttaac ttatgtttga tatatagtag     4500

taagggtttt atgaatgttg attattttgt gccaacagcc cagaattgtc acttatatgt     4560

aagcagaaaa caatgagctc tgcttccaaa gttatttaat tttctcagtg tttgaatgtt     4620

attttttgta agtgtgttaa taaaagtgta aagaattgga aaaaatataa atattcttaa     4680

ctcaagcatt tgctggatca tttttctaca aaacttgttt gtacaatata aaacactctc     4740

tgaagagttg actttttttc agtttcgtat cctggaaatc acattttgta aaactgggga     4800

ccattcataa ttgtcagata ctttttaaaa ttatctcaat acatcacttt tataaaaaaa     4860

aaaagttttt ttgaaagaaa attagataca tatgtggccc cagatgtttg tataactcta     4920

gaatgatcta gactatgtat gtttaaatta actttttatt gaatgtacag gtgtccattt     4980

ttgacgttaa gcatggtcct ttaaggtcac atgacgtttg atttgcaaac atttctatag     5040

ccgaacttgt atatgtggtt gcctccttaa taaacagcct gaccataatg tttattatta     5100

aatttatatt ctttaagtgt ttaattaatc tctggatatg gtaagattcc ttttttcctc     5160

tcagttgcct acacttggtt ttaataaatt actcagttga gtttttcttt aaccacagaa     5220

acccaaatca tattgccctt tcagatttag tcttcatggg gttggattat gtcttatatt     5280

ttctctgtca gagttatttc atatatggat tttacttgaa ggaaatttac agtttactct     5340

aaattgattt gttcttggaa cttttttacc tgctgtgaat tgatacctag ttataaaaag     5400

ctagcatttg cctagatcat aactatgtat ggtatctagt tagaaaaaaa caagcaaaaa     5460

gctattatga gtttccaaga gggacaatta atgcattttc ataccaaatg cgaatattta     5520

ggtgatcacg tgcatctttt cttgtatgga tggaaaaatc aagaattgta cactgtttaa     5580

tgagttctcc atattccttt aggagatatt tgctttgcaa ttacatgtta caattagaat     5640

aattacaatt aaaataatat tacatgttac aattagatta atagtgatga gagggaaaaa     5700

agacaccctt ctgttttttt ctctcaagcc agtctaaaaa cttgaagagc catttaaaat     5760

taaatgtcac tatacttgta ttataaatca atacataagt ttaaacctgt tatatactca     5820

gtgcaacaga aaaacccata tggaggttca accactgatg tattttgaat gatcctaaat     5880

ataagtcttg ggtggctaaa tggccctctg cttaccagtc tgaaaatgaa accgattata     5940

ctcatcggcc ttatttactg taatacaaac tggttaaaac tatgttaact gaatgctagt     6000

ttgaaacaaa ttatctacat taagtcatct taatgttttc tctttaaaag aaataaaaaa     6060

atctgtttct tctgatttcg aaagtaatag aaactctgct gtagaacata aactaaaaat     6120

attaaaaagt ataaaggtaa aaaatg                                          6146


<210> 437
<211> 4758
<212> DNA
<213> Homo sapiens

<400> 437
ggctacatga ttccctgaaa gataagaaca atgttatgtt ggggatattg gtctctgggc       60

caacctggta tcagcaccaa cctgcaggga attgtggctg agccccaggt gtgtgggttc      120

atatctgaca gaagtgtcaa ggaagtggcc tgtgggggaa accactctgt gttcctgctg      180

gaagatgggg aagtttacac atgtggtttg aacaccaagg ggcaactggg ccatgagagg      240

gaaggaaaca agccagaaca aattggagct ctggcagatc agcatatcat tcatgtggca      300

tgtggcgagt cccacagtct ggccctcagt gaccgaggcc agctgttttc ttggggtgca      360

gggagtgatg gtcagctagg actcatgact actgaggatt ctgtggcagt gcccaggtta      420

atacaaaagc tgaaccagca aacaatatta caagtttcct gtggcaactg gcattgcttg      480

gctcttgcgg ctgatggcca gttcttcacc tggggaaaga acagccatgg gcagcttggc      540

ttagggaagg agttcccctc ccaagccagc ccacagaggg tgaggtccct ggaggggatc      600

ccactggctc aggtggctgc cggaggggct cacagctttg ccctgtctct ctcaggagct      660

gtttttggct gggggatgaa taatgccggg cagctagggc tcagtgatga aaaagatcga      720

gaatctccat gccatgtaaa actcttacgc acgcaaaaag ttgtctatat tagttgtgga      780

gaagaacaca cagcagttct cacaaagagt ggaggtgtgt ttacctttgg cgctggttcc      840

tgtgggcaac ttggacacga ctccatgaat gatgaggtta accctagaag agttctagag      900

ctgatgggta gtgaagtaac tcaaattgct tgtggcagac aacataccct agccttcgtg      960

ccttcttctg gactcatcta tgcatttggt tgtggagcaa gaggtcaatt aggaactggg     1020

cacacttgta atgttaagtg cccatctcct gtcaagggtt actgggctgc ccacagtggc     1080

cagctttcag cccgagctga tcgctttaaa tatcatatcg ttaagcagat cttctctgga     1140

ggagaccaga cttttgtact ttgctccaaa tacgagaatt attctcctgc tgttgacttc     1200

aggactatga accaagcaca ttataccagt ttaataaatg atgaaaccat agcagtttgg     1260

agacaaaaac tctcagaaca caacaatgca aatacaatca atggtgttgt tcagatatta     1320

tcttctgcag cctgttggaa tggaagtttt cttgaaaaaa aaattgatga acattttaaa     1380

acgagtccca aaatccctgg gattgacctg aactcaacta gggtgttatt tgagaagtta     1440

atgaactctc agcactccat gattctagaa cagattttga acagttttga aagttgtctg     1500

attccccagt tgtcaagctc accaccagat gttgaagcca tgagaatcta tttaatacta     1560

cctgagtttc ccctactcca ggattccaag tattatataa cattgactat tcccttggct     1620

atggccattc ttcggctgga tacaaacccc agcaaagtac tagataactg gtggtctcag     1680

gtatgcccga aatatttcat gaagctggta aacctctata aaggtgcagt cctttatcta     1740

ctgaggggaa gaaagacatt cttaattccc gtactgttta acaattatat cacagcagct     1800

ctcaaactct tggagaagtt atataaggta aatcttaaag tgaagcatgt ggaatatgat     1860

acattttaca ttcctgagat ttccaatctc gtggacattc aggaagacta cctcatgtgg     1920

ttcttgcatc aagcagggat gaaggctaga ccatcaataa tacaggatac tgtaacactt     1980

tgttcctacc ctttcatctt tgatgcccaa gccaagacca aaatgttaca gacagatgct     2040

gaactacaga tgcaggtggc agtcaatgga gccaacctgc agaatgtctt catgcttctc     2100

accctggagc ctctgctggc cagaagcccc ttcctggtcc ttcacgttcg caggaacaac     2160

cttgttggag atgccctaag agagctgagc attcattctg atattgattt gaaaaagcct     2220

ctcaaagtaa tctttgatgg tgaagaagca gtggatgccg gtggtgttac aaaggaattt     2280

tttcttttgc tgttaaaaga acttttgaat cccatctatg gaatgtttac ctactatcaa     2340

gattcaaatc tcttgtggtt ttcagacacg tgttttgtag agcacaactg gtttcacttg     2400

attggtataa cctgtggact agctatctac aactccactg tggtcgatct ccacttccca     2460

ttggctctct acaagaagtt actcaatgta aagcctggct tggaagactt aaaggagttg     2520

tcacccactg aaggaaggag tctccaagag cttttagatt accccgggga ggatgtggag     2580

gagactttct gcctcaactt cacgatctgc cgagaaagct atggagtgat tgaacagaag     2640

aagctgatac ctgggggaga taatgtaact gtgtgcaagg ataacaggca ggaatttgtg     2700

gatgcttatg tgaattatgt cttccaaatc tcagttcatg aatggtacac agccttctct     2760

agtggcttcc taaaggtgtg tggtggcaaa gtacttgagc tcttccagcc ttcagaactg     2820

agggctatga tggtggggaa cagcaactac aactgggaag aactggaaga gactgccatc     2880

tacaagggag attactcggc cacacatccc actgtaaaac tattttggga aacatttcat     2940

gagtttccat tggaaaagaa gaagaagttt ctcttgttcc tgacaggcag cgatcggatt     3000

cccatctacg gcatggccag tctgcagatt gtcatccagt ccacagccag cggggaggag     3060

tacttgccgg tggcccacac ttgctacaac cttcttgacc tccccaagta cagcagcaaa     3120

gagattctga gtgcccggct gacccaggcc cttgacaact atgaagggtt tagtttggcc     3180

tgaggcttct cagcttgtcc agtatttccc ttcgttcctc agtgtccaca ttgaggccta     3240

tacagaaaat catggggagt gatttctatt tttttattgt ctaagtgggt tgggactttt     3300

aaatactgag cctggttgat gtgtttctgg gattgtatag cagtaaacaa cctttttgaa     3360

aaattagagg ttggggatgg ggtgaaaaat tggcccttgt atgggaggtg tttttgtttt     3420

tgttttaaac caaactaccc agtattcctt gcacttgtga atgtgttgca ctctgctgga     3480

tgaaatggca gtggattttt aaactttaat ttcccaaatg tctctctcag ccctgatgtt     3540

ttctcacagt gcttccttgt ccttctctta acttctcatt cctctataag aatgatttag     3600

actgacctgt ccttttttat ctgcgcatgc gagaacatca ccttcctctg tacacttgga     3660

aatgcctctg gcttgttgca gccctccttt aacccaaagg aggaaaggac tgcttcagaa     3720

actcccaatt ccaaaaagct gagtctgggt ccattatttt ggcagaactc ctaagaattt     3780

atgggagcct atataaacat atcttgcttt taaaaagttc ttgagggaat agcaactttc     3840

ccatggctgt gcctatttcc tagacctttt aaaagatgtg cagagcagct tagcattcgt     3900

tgcagctgag cctaattttt tcttgctcat ccttgtccct ttgacaataa ggttaattga     3960

tagacccacc acctcttgca ctctcgcttt tggagcaagt tgcattaact attttgagtc     4020

tctatattgt ccaagaaaag tagaaataat aaatttactt tccctttttc tatcacctta     4080

tgtcctctac cattttctcc ttcctccctt cccttatttt ctccttttcg taccctgtgt     4140

cctccctgat tttcctttcg tttcttcttt attttatccc attctctgtt acttgactca     4200

gtgctccctt cctctcctct ccttctagtg gatgcatgca gccttttttt caatttttat     4260

ttaaattgca aaatttttac tcagattttt tttcctcttc cctaattgct aagatttaag     4320

gacgttcttt attatgaaac tttatcacat tcgaaatgtt tgtttacagt gggattttag     4380

gggggattgt gtttaaatca aatatatgta ttttaaaaat aatgacatgc tcaaccttcc     4440

tcatcatgga gtaagaaaat tctacatgat taaagaatcc atgtaagtct aattttaaat     4500

tcctagtaac tagagaaaag acttatttat ataaaatgaa gtatttatga actgtgataa     4560

agcatcaaat cttgatgaag gattgtagat ttttgctttt tctttttgtt tttaaaactt     4620

attccaattg ctaaattggt agtttttcag tctttataaa tacaggatta aaaatatata     4680

tacagttata tgaaatgttt attttctatg tgtgtgcata tagttcaata ttatgcaata     4740

aatttggtgt tttaactt                                                   4758


<210> 438
<211> 3779
<212> DNA
<213> Homo sapiens

<400> 438
ggagcctgtc gcagcgggac cgacggaatc cggagcaggc gacagggcgc agaagcggga       60

tgtacttctg ttggggcgcc gactccaggg agctgcagcg ccggaggacg gcgggcagcc      120

ccggggctga gctactgcag gcggccagcg gggagcgcca ctctctgctg ctgctgacca      180

accacagggt cctctcgtgc ggagacaaca gcaggggtca gctgggccgc aggggcgcgc      240

agcgcgggga gctgccagaa ccaattcagg cattggaaac cctaattgtt gatctcgtga      300

gctgcgggaa ggagcactcc ctggctgtgt gccacaaagg aagggtcttc gcatggggag      360

ctggttctga agggcagctg gggattggag aattcaagga aataagtttc acacctaaga      420

aaataatgac tctgaatgat ataaaaataa tacaagtttc ctgtggacac taccactccc      480

tggcattatc aaaagatagc caagtgtttt cgtggggaaa gaacagccat gggcagctgg      540

gcttggggaa ggagttcccc tcccaagcca gcccgcagag ggtgaggtcc ctggagggga      600

tcccactggc tcaggtggct gccggagggg ctcacagctt tgccctgtct ctctgtggga      660

cttcgtttgg ctggggaagt aacagtgccg ggcagctggc cctcagtggg cgtaatgtcc      720

cagtgcaaag caacaagcct ctctcagtcg gtgcactgaa gaatctaggt gtggtttata      780

tcagctgtgg tgatgcacac actgcggtgc ttacccagga cgggaaagtg ttcacatttg      840

gagacaatcg ctctggacag ctgggataca gccccactcc tgagaagaga ggtccacaac      900

ttgtggaaag aattgatggc ctagtttcgc agatagattg tggaagttat cacaccctgg      960

catatgtgca caccactggt caggtggtat cttttggtca tggaccaagt gacacaagca     1020

agccaactca tccggaggcc ctgacagaga actttgacat tagctgcctg atttctgctg     1080

aagacttcgt ggatgttcaa gtcaaacaca tttttgctgg aacatatgcc aactttgtga     1140

caactcatca ggatactagt tccacacgtg ctcccgggaa aaccctgcca gaaataagcc     1200

gaattagcca gtccatggca gaaaaatgga tagcagtgaa aagaagaagt actgaacatg     1260

aaatggctaa aagtgaaatt agaatgatat tttcatctcc tgcttgtctg actgcaagtt     1320

ttttaaagaa aagaggaact ggagaaacga cttccattga tgtggactta gaaatggcaa     1380

gagatacctt caagaagtta acaaaaaagg aatggatttc ttccatgata actacgtgtc     1440

tcgaggatga tctgctcaga gctcttccat gccattctcc acaccaagaa gctttatcag     1500

ttttcctcct gctcccagaa tgtcctgtga tgcatgattc taagaactgg aagaacctgg     1560

tggttccatt tgcaaaggct gtgtgtgaaa tgagtaaaca atctttgcaa gtcctaaaga     1620

agtgttgggc atttttgcaa gaatcttctc tgaatccgct gatccagatg cttaaagcag     1680

ccatcatctc tcagctgctt catcagacta aaaccgaaca ggatcactgt aatgttaaag     1740

ctcttttagg aatgatgaaa gaactgcata aggtaaacaa agctaactgt cgactaccag     1800

aaaatacttt caacataaat gaactctcca acttattaaa cttttatata gatagaggaa     1860

gacagctctt tcgggataac cacctgatac ctgcagaaac ccccagtcct gttattttca     1920

gtgattttcc atttatcttt aattcgctat ccaaaattaa attattgcaa gctgattcac     1980

atataaagat gcagatgtca gaaaagaaag catacatgct tatgcatgaa acaattctgc     2040

aaaaaaagga tgaatttcct ccatcaccca gatttatact tagagtcaga cgaagtcgcc     2100

tggttaaaga tgctctgcgt caattaagtc aagctgaagc tactgacttc tgcaaagtat     2160

tagtggttga atttattaat gaaatttgtc ctgagtctgg aggggttagt tcagagttct     2220

tccactgtat gtttgaagag atgaccaagc cagaatatgg aatgttcatg tatcctgaaa     2280

tgggttcctg catgtggttt cctgccaagc ctaaacctga gaagaaaaga tatttcctct     2340

ttggaatgct gtgtggactc tccttattca atttaaatgt tgctaacctt cctttcccac     2400

tggctctgta taaaaaactt ctggaccaaa agccatcatt ggaagattta aaagaactca     2460

gtcctcggtt ggggaagagt ttgcaagaag ttctagatga tgctgctgat gacattggag     2520

atgcgctctg catacgcttt tctatacact gggaccaaaa tgatgttgac ttaattccaa     2580

atgggatctc catacctgtg gaccaaacca acaagagaga ctatgtttct aagtatattg     2640

attacatttt caacgtctct gtaaaagcag tttatgagga atttcagaga ggattttata     2700

gagtctgtga gaaggagata cttagacatt tctaccctga agaactaatg acagcaatca     2760

ttggaaatac tgattatgac tggaaacagt ttgaacagaa ttcaaagtat gagcaaggat     2820

accaaaaatc acatcctact atacagttgt tttggaaggc tttccacaaa ctaaccttgg     2880

atgaaaagaa aaaattcctc tttttcctta caggacgtga taggctgcat gcaagaggca     2940

tacagaaaat ggaaatagta tttcgctgtc ctgaaacttt cagtgaaaga gatcacccaa     3000

catcaataac ttgtcataat attctctccc tccctaagta ttctacaatg gaaagaatgg     3060

aggaagcact tcaagtagcc atcaacaaca acagaggatt tgtctcaccc atgctcacac     3120

agtcataatc acctctgaga gactcagggt gggctttctc acacttggat ccttctgttc     3180

ttccttacac ctaaataata caagagatta atgaatagtg gttagaagta gttgagggag     3240

agattggggg aatggggaga tgatgatgat ggtcaaaggg tgcaaaatct cacacaagac     3300

tgaggcagga gaatagggta cagagatagg gatctaagga tgacttggac acactccctg     3360

gcactgaaga gtctgaacac tggcctgtga ttggtccatt ccaggacctt catttgcata     3420

aggtatcaaa ccacatcagc ctctgattgg ccatgggcca gacctgcact ctggccaatg     3480

attggttcat tccaggacat tcatttgcat aaggagtcaa accacaccag tcttggattg     3540

gctgtgagcc aattcacctc agtctctaat tggctgtgag tcagtctttc atttacatag     3600

ggtgtaacca tcaagaaacc tctacagggt acttaagccc cagaagattt tgctaccagg     3660

gctcttgagc cacttgctct agcccactcc caccctgtgg aatgtacttt cacttttgct     3720

gcttcactgc cttgtgctcc aataaatcca ctccttcacc acccattcat gcatgtcgc      3779


<210> 439
<211> 1744
<212> DNA
<213> Homo sapiens

<400> 439
acacccgacg ctctggccca cacagacgct actctgtagc atctcaggtt ccctctggct       60

gcactctgga ggaccacact cgttttcttt ttggctgcca gaggcccccg catccaccgc      120

tgagctggga gaaagatggc ggcagccgtg cgacaggatt tggcccagct catgaattcg      180

agcggctctc ataaagatct ggctggcaag tatcgtcaga tcctggaaaa agccattcag      240

ttatctggag cagaacaact agaagctttg aaagcttttg tggaagcaat ggtaaatgag      300

aatgtcagtc tcgtgatctc gcggcagttg ctgactgatt tttgcacaca tcttcctaac      360

ttgcctgata gcacagccaa agaaatctat cacttcacct tggaaaagat ccagcctaga      420

gtcatttcat ttgaggagca ggttgcttcc ataagacagc atcttgcatc tatatatgag      480

aaagaagaag attggagaaa tgcagcccaa gtgttggtgg gaattccttt ggaaacagga      540

caaaaacagt acaatgtaga ttataaactg gagacttact tgaagattgc taggctatat      600

ctggaggatg atgatccagt ccaggcagag gcttacataa atcgagcatc gttgcttcag      660

aatgaatcaa ccaatgaaca attacagata cattataagg tatgctatgc acgtgttctt      720

gattatagaa gaaaattcat tgaagctgca caaaggtaca atgagctctc ttacaagaca      780

atagtccacg aaagtgaaag actagaggcc ttaaaacatg ctttgcactg tacgatctta      840

gcatcagcag ggcagcagcg ttctcggatg ctagctactc tttttaagga tgaaaggtgc      900

cagcaacttg ctgcctatgg gatcctagag aaaatgtatc tagataggat catcagagga      960

aatcaacttc aagaatttgc tgccatgctg atgcctcacc aaaaagcaac tacagctgat     1020

ggttccagca tcttggacag agctgttatt gaacacaatt tgttgtctgc aagcaaatta     1080

tataataata ttaccttcga agaacttgga gctcttttag agatccctgc agctaaggcg     1140

gaaaagatag catctcaaat gataaccgaa ggacgtatga atggatttat tgaccagatt     1200

gatggaatag ttcattttga aacacgagaa gccctgccaa cgtgggataa gcagatccaa     1260

tcactttgtt tccaagtgaa taaccttttg gagaaaatta gtcaaacagc accagaatgg     1320

acagcacaag ccatggaagc ccagatggct cagtgaatcc ttgcagaact tctgtgcaca     1380

tgacatcttt ttccatgttg tgcagatcag tttcactatc tccaaagcat ttgcatcatg     1440

accttataca tttcaatccc ttttatgctg gattccgttt aaagaagaca ttattagagc     1500

aggaagtaca agcatttaaa atatgtagtt cccatatatt tcagggtctc tgtgtattaa     1560

gctaactcag atgttttgaa agctttttct ttaaacagag gtgaaatatc tgtggctaaa     1620

aagtttgaga tttgtgataa ctttgtagtc atgtaaaact taagtgcttc atgcctctcc     1680

aaatgtggtt attctaataa atggagaaat gagccaaata aaagtagtac tttgttttta     1740

gtta                                                                  1744


<210> 440
<211> 2145
<212> DNA
<213> Homo sapiens

<400> 440
atttctccag tgctgctaca gaatgggact ttttgcttga ccttgtggaa actcatgggt       60

tctccaagtt gtaaagagtt aagaaaaggg atggaatgtc tggggaatgt tgcagggaag      120

gctgcagctc tctgctctta gctttctcac cctggagggg atcccaacac tcggtggtgc      180

ttctgggtct gaggtcttcc ctaagttctg tttgatctgc caaagagcca gcctcagtcc      240

actgagaaac agggatgtgc cgttatctgc acactgaggt ttatttttac cttgtccctg      300

gtgagtcccc agagacaagg agaaaacact ttgggaggga gttaagagcc ttttgcttat      360

ccttgaagga aagcagtctc tgaggattag tgagggtggt ggtgagggta ggtaggggga      420

ggagagtcag aggaatcaga gttatttgga ctgcattttt tccttgcctg attaaatctt      480

actgacattg gcactttgtg tcactaaaag aacacagccc tggatgtggg gccagggacc      540

agagggttgg cggcagagtc tggggctggc atggctgctg ggctgcttgg ctctgaggac      600

ccaccgtgga gttggaacct gacttgtcgg gcgctgagga cctgccaagt gaggaacatt      660

cgagttctgc agctgctgct aaaaccatgg tgcatctcca gggccgtcta tcagatgacg      720

gagggccgcc gatgtcaagt acatcttctt gatgacagga agctggaact cctagtacag      780

cccaagctgt tggccaagga gcttcttgac cttgtggctt ctcacttcaa tctgaaggaa      840

aaggagtact ttggaatagc attcacagat gaaacgggac acttaaactg gcttcagcta      900

gatcgaagag tattggaaca tgacttccct aaaaagtcag gacccgtggt tttatacttt      960

tgtgtcaggt tctatataga aagcatttca tacctgaagg ataatgctac cattgagctt     1020

ttctttctga acgcgaagtc ctgcatctac aaggagctta ttgacgttga cagcgaagtg     1080

gtgtttgaat tagcttccta tattttacag gaggcaaagg gagatttttc tagcaatgaa     1140

gttgtgagga gtgacttgaa gaagctgcca gcccttccca cccaagccct gaaggagcac     1200

ccttccctgg cctactgtga agacagagtc attgagcact acaagaaact gaacggtcag     1260

acaagaggtc aagcaatcgt aaactacatg agcatcgtgg agtctctccc aacctacggg     1320

gttcactatt atgcagtgaa ggacaagcag ggcataccat ggtggctggg cctgagctac     1380

aaagggatct tccagtatga ctaccatgat aaagtgaagc caagaaagat attccaatgg     1440

agacagttgg aaaacctgta cttcagagaa aagaagtttt ccgtggaagt tcatgaccca     1500

cgcagggctt cagtgacaag gaggacgttt gggcacagcg gcattgcagt gcacacgtgg     1560

tatgcatgtc cggcattgat caagtccatc tgggctatgg ccataagcca acaccagttc     1620

tatctggaca gaaagcagag taagtccaaa atccatgcag cacgcagcct gagtgagatc     1680

gccatcgacc tgaccgagac ggggacgctg aagacctcga agctggccaa catgggtagc     1740

aaggggaaga tcatcagcgg cagcagcggc agcctgctgt cttcaggttc tcaggaatca     1800

gatagctcgc agtcggccaa gaaggacatg ctggctgcct tgaagtccag gcaggaagct     1860

ctggaggaaa ccctgcgtca gaggctggag gaactgaaga agctgtgtct ccgagaagct     1920

gagctcacgg gcaagctgcc agtagaatat cccctggatc caggggagga accacccatt     1980

gttcggagaa gaataggaac agccttcaaa ctggatgaac agaaaatcct gcccaaagga     2040

gaggaagctg agctggaacg cctggaacga gagtttgcca ttcagtccca gattacggag     2100

gccgcccgcc gcctagccag tgaccccaac gtcagcaaaa aactg                     2145


<210> 441
<211> 2158
<212> DNA
<213> Homo sapiens

<400> 441
ggcgtttccc agaaggccca gcgccgggaa ggggtttgca gctgctccgt catcgtgcgg       60

cccgacgcta tctcgcgctc gtgtgcaggc ccggctcggc tcctggtccc cggtgcgagg      120

gttaacgcga ggccccggcc tcggtccccg gactaggccg tgaccccggg tgccatgaag      180

caggagggct cggcgcggcg ccgcggcgcg gacaaggcga aaccgccgcc cggcggagga      240

gaacaagaac ccccaccgcc gccggccccc caggatgtgg agatgaaaga ggaggcagcg      300

acgggtggcg ggtcgacggg ggaggcagac ggcaagacgg cggcggcagc ggctgagcac      360

tcccagcgag agctggacac agtcaccttg gaggacatca aggagcacgt gaaacagcta      420

gagaaagcgg tttcaggcaa ggagccgaga ttcgtgctgc gggccctgcg gatgctgcct      480

tccacatcac gccgcctcaa ccactatgtt ctgtataagg ctgtgcaggg cttcttcact      540

tcaaataatg ccactcgaga ctttttgctc cccttcctgg aagagcccat ggacacagag      600

gctgatttac agttccgtcc ccgcacggga aaagctgcgt cgacacccct cctgcctgaa      660

gtggaagcct atctccaact cctcgtggtc atcttcatga tgaacagcaa gcgctacaaa      720

gaggcacaga agatctctga tgatctgatg cagaagatca gtactcagaa ccgccgggcc      780

ctagaccttg tagccgcaaa gtgttactat tatcacgccc gggtctatga gttcctggac      840

aagctggatg tggtgcgcag cttcttgcat gctcggctcc ggacagctac gcttcggcat      900

gacgcagacg ggcaggccac cctgttgaac ctcctgctgc ggaattacct acactacagc      960

ttgtacgacc aggctgagaa gctggtgtcc aagtctgtgt tcccagagca ggccaacaac     1020

aatgagtggg ccaggtacct ctactacaca gggcgaatca aagccatcca gctggagtac     1080

tcagaggccc ggagaacgat gaccaacgcc cttcgcaagg cccctcagca cacagctgtc     1140

ggcttcaaac agacggtgca caagcttctc atcgtggtgg agctgttgct gggggagatc     1200

cctgaccggc tgcagttccg ccagccctcc ctcaagcgct cactcatgcc ctatttcctt     1260

ctgactcaag ctgtcaggac aggaaaccta gccaagttca accaggtcct ggatcagttt     1320

ggggagaagt ttcaagcaga tgggacctac accctaatta tccggctgcg gcacaacgtg     1380

attaagacag gtgtacgcat gatcagcctc tcctattccc gaatctcctt ggctgacatc     1440

gcccagaagc tgcagttgga tagccccgaa gatgcagagt tcattgttgc caaggccatc     1500

cgggatggtg tcattgaggc cagcatcaac cacgagaagg gctatgtcca atccaaggag     1560

atgattgaca tctattccac ccgagagccc cagctagcct tccaccagcg catctccttc     1620

tgcctagata tccacaacat gtctgtcaag gccatgaggt ttcctcccaa atcgtacaac     1680

aaggacttgg agtctgcaga ggaacggcgt gagcgagaac agcaggactt ggagtttgcc     1740

aaggagatgg cagaagatga tgatgacagc ttcccttgag ctggggggct ggggaggggt     1800

agggggaatg gggacaggct ctttccccct tgggggtccc ctgcccaggg cactgtcccc     1860

attttcccac acacagctca tatgctgcat tcgtgcaggg ggtgggggtg ctgggagcca     1920

gccaccctga cctcccccag ggctcctccc cagccggtga cttactgtac agcaggcagg     1980

agggtgggca ggcaacctcc ccgggcaggg tcctggccag cagtgtggga gcaggagggg     2040

aaggatagtt ctgtgtactc ctttagggag tgggggacta gaactgggat gtcttggctt     2100

gtatgttttt tgaagcttcg attatgattt ttaaacaata aaaagttctc cacagtgc       2158


<210> 442
<211> 10370
<212> DNA
<213> Homo sapiens

<400> 442
gggttgaagt tgaggctgag gagagagccg agctagcgac gagcagtcgt tgcggccgcc       60

ggcgccgcgg gaggtggtgg aggcctagcc ggagccgaga ggtctcttgt tcccgtccca      120

cggtcccggc gtcacccctc cggcgcccag tccccgtccc ggaactcccg ggcctgtcct      180

gggcccccgg tctgtgcact ccgctcgccg cagcgcccgg cccgggccgc acccgccggc      240

cccatgagga gggacgtgaa cggagtgacc aagagcaggt ttgagatgtt ctcaaatagt      300

gatgaagctg taatcaataa aaaacttccc aaagaactcc tgttacggat attttctttt      360

ctagatgttg ttaccctgtg ccgctgtgct caggtctcca gggcctggaa tgttctggct      420

ctggatggca gtaactggca gcgaattgac ctatttgatt tccagaggga tattgagggc      480

cgagtagtgg agaatatttc aaaacgatgt gggggctttt tacgaaagtt aagtcttcgt      540

ggatgtcttg gagtgggaga caatgcatta agaacctttg cacaaaactg caggaacatt      600

gaagtactga atctaaatgg gtgtacaaag acaacagacg ctacatgtac tagccttagc      660

aagttctgtt ccaaactcag gcaccttgac ttggcttcct gtacatcaat aacaaacatg      720

tctctaaaag ctctgagtga gggatgtcca ctgttggagc agttgaacat ttcctggtgt      780

gaccaagtaa ccaaggatgg cattcaagca ctagtgaggg gctgtggggg tctcaaggcc      840

ttattcttaa aaggctgcac gcagctagaa gatgaagctc tcaagtacat aggtgcacac      900

tgccctgaac tggtgacttt gaacttgcag acttgcttgc aaatcacaga tgaaggtctc      960

attactatat gcagagggtg ccataagtta caatcccttt gtgcctctgg ctgctccaac     1020

atcacagatg ccatcctgaa tgctctaggt cagaactgcc cacggcttag aatattggaa     1080

gtggcaagat gttctcaatt aacagatgtg ggctttacca ctctagccag gaattgccat     1140

gaacttgaaa agatggacct ggaagagtgt gttcagataa cagatagcac attaatccaa     1200

ctttctatac actgtcctcg acttcaagta ttgagtctgt ctcactgtga gctgatcaca     1260

gatgatggaa ttcgtcacct ggggaatggg gcctgcgccc atgaccagct ggaggtgatt     1320

gagctggaca actgcccact aatcacagat gcatccctgg agcacttgaa gagctgtcat     1380

agccttgagc ggatagaact ctatgactgc cagcaaatca cacgggctgg aatcaagaga     1440

ctcaggaccc atttacccaa tattaaagtc cacgcctact tcgcacctgt cactccaccc     1500

ccatcagtag ggggcagcag acagcgcttc tgcagatgct gcatcatcct atgacaatgg     1560

aggtggtcaa ccttggcgaa ctgagtattt aatgacactt ctagagctac cgtggagtct     1620

ctccagtgga agcaacccca gtgttctgag caagggttac aaagtgaggg agggcagtgt     1680

ccagatcccc agagccacac atacatacac atacacaccc ttacccccat ccactctagc     1740

tttgtgacca tgggactgaa gtttgtgatg gcttttttat caagtagatt ggtaaaattt     1800

aaccattcct gttgaggtgc ccataagaaa atcataggcc aagataggga ggggcattcc     1860

agcaaacccc gtgttaatgc tactgtggtt tttaaatttt tgtctagggg tttctttggg     1920

gattttagaa cagcatctgc tgtcctccgg ggtcaagaaa agcatggaaa gacaatatat     1980

gatgtaccca gggaccagaa agaaaatttc tttgcatctt agaaatggta gacattcatt     2040

gtgactaaag agcttctatg cttccttgtt tccatgccaa catgctgagc atgctcacaa     2100

agaaggctcg tccattcctc ctgtgtttta gtatttggcc cagaggtttc ctaaatggtt     2160

gccttgaaat cactgtggtc caaatgtaat tcttacacac tcaaattatc actgtctgta     2220

gcacacttgt gcacctgtct tacattctct gttgctcccc cccacactct tgctcagtct     2280

gtcacctgtt cagtctgctt actcactcaa ttgttaccct tttgctgttg tcgtgtttac     2340

agtttgcatt ttgaatgatt agttgggatt accaaacatt ttttaaaaag atattatcaa     2400

taaatatttt tttaattcta aattttacca ttaggggacc ctgcctgaat ctttgccaac     2460

ctgcaaggaa actctaatga aagcaagaaa agttatgaga agaaactgtt ttgatgaaaa     2520

cagatgctac cttttggttt ctattttatc ttctgatatg tgataattcg catggtatcc     2580

ccaatattcc ccctacatat tcttccttct gtcagactcc accaactgta tcataaggaa     2640

agagagagat gtattattag gaaagagtga aaatgataaa tcacaaaaca gagcctgaaa     2700

gtccccaaca cccaagttca gacattaatg attaatgtta ttatatattt actgaaatct     2760

aggagtgatc agtggcatct ctgacctatg aggttgtttt aacaggaatg ccactagagg     2820

agctgtgtat tctagccagt ctgtttctct cttttccccc atttcagcct ttcagggata     2880

caagaatggc tctataacag ctggtcaatt gtatgtcagt gttaatggat tcatatctag     2940

tgttggcacc ccaaagggcc agaaccttcc cataacctgt cagtcatctc tcttttctgc     3000

cccagtcttt tttttttttt tttttttttt ttaagacggg ttctcactct tgcccagact     3060

ggagtgcagt ggtgcgatct cggctcaccg caacctccac ttcccaggct caagcgattc     3120

tcttgcctca gcctaccgag tagctgggat tacaggcatg caccactact gcctggctaa     3180

tttttgtatt tttagtagag atggggtttc acatgttggc cagcctggtc ttgaactcct     3240

gacctcaaat gatccacctg cctcagcctc ccaaagtgct gggactacag gcatgagcca     3300

ccatgcccgg ccctgttcag acttctgaat gaagtatgaa tgtagccagg tgaagcattg     3360

aggcagctga aagagaacac tgagaggaag taaggggttt agtgtctctg cttagcctgg     3420

gcactagaac tgagggagga atttagtgtc caggactcaa gagtccaaga agaagcaccc     3480

tctgtcttcc caaaaaatca gaggataaag gaagtaaaat gagtttttaa agcataagaa     3540

gaaaatttct aaaccccaag attagaaacc cagtgtgatt tttagtaggg tgattttggc     3600

ggggggtgtc ctttgagaca ttaatgtgca atccatcata atattaatct tctatatgat     3660

ccagactatt aaaaggcttg ttttatttat ttattttatt ttattttatt tttttagaga     3720

tggggtctcg ctatcttgcc cagcctggac tcaaactcct gggctcaagc cttcctccca     3780

cctcagcctc ccaagtagct gggactacag gtgtgtgcca ctgtacccag cttaagaggt     3840

ttgttttaat gctgcagttg ctgattatac cagcatatat aagaataaag tctgatttat     3900

ttatccattg atttagaagg caattggatg aaagggtctt agaagtctat actatccatt     3960

aatatttatc atattaaatt tattttaaat cctgttttat tgtgccgctt taaaaacgca     4020

gattacttgt ttattcattc ccctttcccc ttattctctt tcagattacc ttataaggaa     4080

tatagttttt aacatgaaac tcagtttctt gtctgtaccc ctacacataa aaatacatac     4140

gtgcatacac acatacttcc agatgtggtt aataatattc agatccctag gttactcaaa     4200

caaaactaaa ggagagaact atttaggggc catctgcttt aaagtttaag gtgttttgtt     4260

gttgttttag tgcctgtaca aattgaccat aaaacccaga ttgattagtg agtgtggatt     4320

tgagttgcct aagttgaggc tattaaggta cttctttact taaaagataa gtttaaaaga     4380

ctctattcat cagttcatga tgatcttgga aatgctgttt ctctgctcaa aggatatacc     4440

cacaggcagg tccatgggga cttgctctgg tgatctctgc tattaaggca aattccagcc     4500

tgtttgtgcc aagaacagag tcaagtgaga gagaatgaag actcagagat gtgcagcact     4560

ggcttgtatg ttgtcaggca gaagccttgt tcctttctca agaaaacttc aggcctatca     4620

agcttggaag gaaatacatt tttttatgct gatttgcagc ctacaccagc tgatgaatat     4680

gctaggactt tgagagaaca caaagcatgg taagttttgg tcaggtggaa aggagcctga     4740

catctgaaca taatgcttcc tctctcaaca tctgggatac ttttgaaaat tcagtaaggc     4800

ttaatgtagg aaaaattctt tacaggaaaa gctaattgat ctgtttgtct aacctcatag     4860

ccactccaaa atatgccttt tataatggaa aaaaacagtg aacagagaga agagatttgg     4920

ggataagtta gaaggtaccc tcaaaactac tgccgtaaac ctacaggtgg gcaaggagga     4980

attactgtag tgtctctgga gaaagttctt gaacatccaa atcatctctt ttctaagcag     5040

tttttcccct aatctcatac cttacatctt ccagcatcat ttgctacatc aatgtctttt     5100

catcctcttc atcagcccca ttgagctgac tccagcttat ttttgcactg atttccacca     5160

tttccttccc acacccatcc tttccctcta tttaaagcct ccatctcacc ctcagtaatg     5220

ctgctgattt actctcagat gtctcaagtc tagcttcctt tttgaatcct tctcctactc     5280

caggggctgt caaaggcagc cttaaagttc agtgactgtt aggtggctca ggccattttt     5340

cattgggtgg tctttggtgt ttgcatactg aatttgaatt cagtttaaaa gcaaactgtt     5400

ggatatgagg aagaaaggga tatggcctta gccctttttc caatatttgg aatatgaaag     5460

catattgtgc tttgtgtaaa aaatgttttc ttctcctatt ctgctcttgt ctttactgaa     5520

ggtaaaagta ttccttaagt agcttttgca aatttctagt ctgatttcca cattcattaa     5580

gttgatttag cagacatgta agtcagaagt ttcacatatc ccttgtatca aacattttat     5640

agggaaacct agtaaattta tgatgcttca ttttgggctt tccagactat ttgagttatt     5700

caagatagcc ataatgtttt agtagcgaca ttcttttatt acttctaatt gccttgtaaa     5760

atgcattgtt atggcccggc acggtgggtg gatcacaagg tcaggagttc aagaacagcc     5820

tggccaagat ggtgaaatgc tgtctctact gaaaatacaa aaattagcca ggtgtggtgg     5880

caggtgcctg taatcccagc tactcgggag gctgaggcag agaattgctt gaacccggga     5940

ggtggaggtt gcagtgagct gagatcgcac cactgcactc caccctgggc gacagagtga     6000

gactatctca aaaaaaaaga aagaaagaaa gaaaaaaatg catcgttact agtttgatag     6060

cccactaatg ccatggggga ctaaacaaaa tatgtgatga aacctgtctt ggtttgaagt     6120

tgttagaaag tgtgagagtg tcactggaaa gaagagagtg gcttcctgcc tgcttgttta     6180

gtcagcatgt ccttaggtga ctgtgttgtt gggagaagag cactcatggg tcatgggtga     6240

cccttggcca ttttatgttt attgtgctga aagtcacagg cggctcatgc cagttgctac     6300

cagtgagagg aggggtttaa aggaaattgc tctattttgc cttattcctc cttatgtgta     6360

tgatttaagg gtaggctttt atcctggttg tatctcctgg ctgacagact ttctcaatca     6420

tatgtttgag ctctgaagca ttttacaaaa agattgcctc tctatctgcc tgccaatcct     6480

agaatcttta gccacctcaa acccaggcac tgtgaattag ccaagtcctg tttgagaaga     6540

aatgtaggat gtttggttgg aattcttgag acagaacctc tctccccatt aatgatgttg     6600

taccaaagaa ttctaaagca gtaaaaggat aatggggaaa aatggagtca cagcctttcc     6660

tcgcctatat ttcttttttt tttttttttt tttgacatgg agtctcgctc tgtcacccag     6720

gttggagtgc catggcacaa tctcagttca ctgcaacctc tgcctcctgg gttcaagtga     6780

ttcttctgtt tcagcctccc aagaggccag gattacaggt gcccaccacc acgcccagct     6840

aatgtttgta tttttcatag agatggggtt ttgccatgtt ggccaggcta gtctcgaact     6900

tctgacctca agtggtccac ctgccttggc ctcccaaagt gctgggatta caggtgtaag     6960

ccaccgcacc tggccagttt ctatcataaa ttttaaatgt aagattggaa gatacagaga     7020

gctgtataaa atcataccag tagggtataa ttagcccagg tagtttagga ataaaattgg     7080

gttgtatccg agtgccctaa cttgacattt tgattctcca gcaaagaaca taggttacta     7140

ggttactaac cttgccttct cacttgggat aaactttttt tttttttctt gttgcccagg     7200

ctggagtgca atagtgagat ctcggctcac cgcaacctcc gcctcttggg ttcaagcgat     7260

tctcctccct tagcctcccg agtagctgga attacagcct gtgccaccac gcccggcaaa     7320

atttgtattt ttagtagaga cggggtttca ccatgttggt caggctggtt tcaaactccc     7380

aacctcaggt gatctgccca cctcagcctc ccaacatgct aggattacag gcgtgagcca     7440

ctgcgcccag cccaggataa acattctacc tgcctgaaag taccataaga ggcaagtgag     7500

tttcttgcat gatgggcttc tgcagcttcc ccctcaagtc acatctacct gttgtattta     7560

tttatttatt tatttttgag acagagtctc gctctgtttc ccaggctgga gtgcagtggc     7620

gtgatctcgg ctcactgcaa gctccacctc ccaggttcac gccattctcc tgcctcagcc     7680

tcccaagtag ctgggactac aggctcccgc caccacgccc ggctaatttt ttgtattttt     7740

agtagagacg gggtttcacc ctgttagcca ggatggtctc gatctcctga cctcatgatc     7800

cacccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccgc gcccggcccg     7860

ttgtatctat tttttttaga cgcatcaatt cagtgtctct gaagcctttg atcgttagga     7920

aggtcagtac ataacctctt aggtgaagct gagttgatct ttggagccca agagagttaa     7980

ttttcaggag aaaaagaatt agggcaagct cccctgtggg atgttaagag aaagtccata     8040

tgcgcttctt ccatctctgc ctcttgtttt taaataagtg cttgtgaagt tcagtttata     8100

gaggttgagt ctcagtgctt cctcagccag ggtggtttat tgctgtttta caaagaacca     8160

tgaacaagca aaatcctatc aatagtcctt tctgttttat gttttatagt cttattttga     8220

agaatcggca tggtaaaatg atagacaagt ttcaaataaa gcagataatt agctctagaa     8280

ttggggtact ttgcctcagg tacagcatct gtcttgaata catagtgatg gctgtgtcac     8340

acatgggtac atttactttc ctctctgatc aactgcaccc ctttttactg gcaaagaggg     8400

ctcctacttt ctacacactt aaccagtcaa acagataggt tttggcacca ccgaaagaac     8460

cacaagtgca ccccagctgc atctgggcat ggttttggta ctaggactag agaagtgagc     8520

agtaaatgac agtccttacc ctaggaagag atgggagaag agaggtgtcc agacatattt     8580

accttttctc ttctgtcatg ccccaagaac caaggatcat ctttgaagtg acgtcttttt     8640

tgttaaattg gaagaagaaa actttgcagc caggcgtggt ggctcacgcc tgtaatccca     8700

gcactttggg aggccgaggc gggcggatca caaagtgtca ggagtttgag aacagcctgg     8760

ccaacatggt gaaaccccat ctctactgaa aatacaaaat cccagctact tgggaggctg     8820

aggcaagaga atcacttgaa cctgggaggc ggatgttgca gtgagccgag atcacgccac     8880

tgcactccag cctgggcaac ggagtgagac tccatctcac aaaaaagaga aaagaaaaga     8940

aaactttgct tcactaagtt tctcttgcca ttatctcatt aattcagatc tgtacctcat     9000

tgctgctcac acatatatgt ttcttacctt agcctgaacc ttctcaggcc ttgaagtcat     9060

tattctactc tttttttttc ttttcctttt ttatggcact agagaatgaa aacctaaggt     9120

cttagaaaat cttaacttga aaaagtctct aactggcatg atttgattac ttttttcccc     9180

tgtggacaaa taattttctt tcctatataa tagattttta gtaagtgaaa cctttgctgc     9240

tgctttcctg ggtttacatt agttttttcc tgcccttaag aataatttat ctgtgcttct     9300

ctgatgactg ttaatttcta atagtgcagg aagggatgag cttttgattt cttctcactc     9360

ccctcctcac cctacttcca aattacacac taacttctaa cccttacagc ctgttggcac     9420

atacacaaga tccacgagac catgctcctc agaagctacc catgtccttt ctcaccatgg     9480

tgtggctctt ggagccctga gtatctgtga ctacccactc caaaggttga ctgtaagagg     9540

agagcggcct tcttaatttt gcatttctta attttgtttt tctccattcc tgttttatga     9600

cttggccttc agatgcttcc tactctggcc tcctcctttt ttctcctagg aattgtttcc     9660

aggtaaccta ccatgtgcac ttctcagctg ctctgctcac ctttgcccac cttcccgtga     9720

ccctgagagt acagatccga ataatgtggc ctgtgcagag ctcagagaac tgtgaggact     9780

acccatgcct gtcagactct gctcagggac agagatggat gggtaaatgg tgctgttgga     9840

gacattttta tcttcatacc aggctctgtt tcatccctgc accccgcacc cccactcact     9900

cccctgaggg ggtaaaatgc agaggtggtt gacctgaagg gtctgattcc ctccttccca     9960

agccttaggg cctaccctgg agtgctgcag tgtgtgagag ctgctgcttg cttgtttctc    10020

cactaggcct gctccaaatg cttagccaat ctctggagcc gacacagttg cctacggggt    10080

gacttagcac caggttccat tagctctcca agtgactgtt tccacccagt acttttggcg    10140

cttgaggatg gggggagggg gattatttaa aataaataaa atccgaggtg gcagtagagg    10200

attccttttg ctttaaaaat ctttggacta aaaaaaaaaa aaaaaagttt tttatatata    10260

aatatataaa gtaaattgtt atgtaactat tattgtttct tgtatgttct aattttgttt    10320

tatgatgtaa ttaaagaaag taagctgtga agacttttca ttttcctgtg               10370


<210> 443
<211> 2496
<212> DNA
<213> Homo sapiens

<400> 443
attgcggaag tttctctacc catgcggtgt ctctatggtc gggtgggtgg ggccaggagg       60

aagatggcgg cgtccgcagc tgccgctgag ctccaggctt ctgggggtcc gcggcaccca      120

gtgtgtctgt tggtgttggg aatggcggga tccgggaaaa ccacttttgt acagaggctc      180

acaggacacc tgcatgccca aggcactcca ccgtatgtga tcaacctgga tccagcagta      240

catgaagttc cctttcctgc caatattgat attcgtgata ctgtaaagta taaagaagta      300

atgaaacaat atggacttgg acccaatggc ggcatagtga cctcactcaa tctctttgct      360

accagatttg atcaggtgat gaaatttatt gagaaggccc agaacatgtc caaatatgtg      420

ttgattgaca cacctggaca gattgaggta ttcacctggt cagcttctgg gacaattatc      480

actgaagccc ttgcatcctc atttccaaca gttgtcatct atgtaatgga cacatcgaga      540

agtaccaacc cagtgacctt catgtccaac atgctctatg cctgcagcat cttatacaaa      600

accaagctgc ctttcattgt ggtcatgaat aaaactgaca tcattgacca cagctttgca      660

gtggaatgga tgcaggattt tgaggctttc caagatgcct tgaatcaaga gactacatac      720

gtcagtaacc tgactcgttc aatgagcctg gtgttagatg agttttacag ctcactcagg      780

gtggtgggtg tctctgctgt tctgggtact ggattagatg aactctttgt gcaagttacc      840

agtgctgccg aagaatatga aagggagtat cgtcctgaat atgaacgtct gaaaaaatca      900

ctggccaacg cagagagcca acagcagaga gaacaactgg aacgccttcg aaaagatatg      960

ggttctgtag ccttggatgc agggactgcc aaagacagct tatctcctgt gctgcaccct     1020

tctgatttga tcctgactcg aggaaccttg gatgaagagg atgaggaagc agacagcgat     1080

actgatgaca ttgaccacag agttacagag gaaagccatg aagagccagc attccagaat     1140

tttatgcaag aatcgatggc acaatactgg aagagaaaca ataaatagga gactttagca     1200

cacttcactt gtttctagaa gtccagaatt ttggacctcc acgtgaaaga actgttctta     1260

cctctgaact gggggctccc ataagggata attttcctca gagtagcaaa gtttctctta     1320

ttagagaaat cttgtgactc agatgaagtc agggatagaa gacccttgga cctggcaggt     1380

taatgctgat tattccttgg cctttccctt gtatttatgc aaggaaggat atactgagct     1440

gatactcttc caagcctaca acttcaagtt ttatcatttg aactcaagta cttttgctgc     1500

tgaggaatgg aatcaaaaga acgtagtctc ctggtgacca cctcagatct ctattattag     1560

gctagatgta tagcctctac tcccccagct tcttgctctt gaccctgcac tgtaagttgc     1620

ccttctatta gcagccaagg aaaagggaaa catgagctta tccagaacgg tggcagagtc     1680

tccttggcaa tcaaccaacg ttgctatgaa atatgcctca cactgtatag ctcattatag     1740

gacgtcaggt ttgttgaaaa aagtgggcaa gacatgatta atgaatcaga atcctgtttc     1800

attggtgact tggataaaga ctttttaatt ttaactttgt tctaagactg cttgtcatga     1860

tttcaaatta gaaaattata taattgcaaa cagcttcact tctcctgttc aacagaggct     1920

taaggccaga tgtccaaact tgtctcaata aggaggtgat attttactaa agtttcccac     1980

gtgcacatac tgactaaata cagagctagg cccagtttgt attgtactct gaacttaatg     2040

caaagtctcc ttggtgattt tcgcaaagtc cgtggatttg ggtcagaggc acatttcata     2100

cataacagcc cttataaacg tttgccctgc ctccacattt tacagtatct taaaacagta     2160

catttctttc aaagaatttt atctctatga gtcagtactc caacttagtg gttctcacat     2220

tgtggaccag gagcatcagc atcatctggg gaattgttca acttacctct tataacctat     2280

gaactcagaa accctggggg tgggctgagc agtctgtttt agaaagccct ccatgtgatt     2340

ctgatgcata gtagcctatg acataattcc agaccaggtg aatctcaaga tactaatcct     2400

cacatcattt gccttctcat atttccctcg tcttgaccat ctggtgcctg ttatgcagtt     2460

taacattctg cagcaataaa agtgttttat tataaa                               2496


<210> 444
<211> 8794
<212> DNA
<213> Homo sapiens

<400> 444
gcgcgcgcgc gcgcgtgttt gtgtgtgtgt ttcccctgcc gcggggaaat ggctgctgtt       60

gcttctgggc cagaggaaga gaatgagact aatagggatg ccaaaggaaa aatatgatcc      120

tccagatcct cgcagaattt ataccatcat gtcagcagag gaggtagcca atgggaaaaa      180

atctcactgg gcagaattag aaatctcggg tagagtgcgg agcctaagta catcactttg      240

gtcattgaca cacttgacag cgctgcacct aaatgacaat taccttagtc gcattccacc      300

tgatattgcc aagcttcata atctggttta cctggatctg tcatccaata aactcagaag      360

tttaccagca gaactaggaa acatggtgtc tctcagggaa ttgcttttaa ataacaatct      420

gttacgggtt ttgccttatg aacttggtcg gctcttccag ctacaaactc taggtttgaa      480

aggcaatcct ttatcacagg atattctcaa cttataccag gacccagatg gaacccgaaa      540

gctactgaac ttcatgcttg acaatctcgc agttcatcca gagcagcttc ctccgaggcc      600

atggattaca ttaaaagaac gagaccaaat tctgccgtca gcatcattca cggttatgtg      660

ttacaatgtg ttatgtgata aatacgctac ccggcagcta tatggctatt gcccatcctg      720

ggcattaaac tgggaataca ggaaaaaggg aattatggaa gaaattgtta actgtgacgc      780

agatatcatt agtcttcagg aagtggaaac agagcaatac ttcactctct ttctgccagc      840

attgaaggag cgtggatatg atggattttt ttctccaaag tcacgtgcca aaatcatgtc      900

tgagcaggag agaaagcatg tagatggttg tgcaatattc ttcaaaacag aaaaatttac      960

attggtgcag aagcatacag tggaatttaa ccaagtggcg atggctaatt cagatggatc     1020

cgaagctatg ctgaacagag tgatgacaaa agataacatt ggtgtcgctg tggtattaga     1080

ggtccacaaa gaactatttg gagcaggtat gaagcctatt catgctgcag acaaacagct     1140

gcttatagtg gcaaatgccc acatgcattg ggacccagag tattctgatg tgaagctcat     1200

ccagaccatg atgtttgtct cagaggttaa aaacattctg gagaaagcct ctagtaggcc     1260

tggaagccca actgcagatc ctaattccat cccgctggtg ctatgtgcag atcttaactc     1320

attgccagat tcaggtgttg tggaatactt aagcaatgga ggagtagctg acaaccataa     1380

agacttcaag gaactaaggt acaatgagtg tcttatgaac ttcagctgca atggaaagaa     1440

tggaagctca gaagggagaa tcacacatgg cttccaactt aagagcgcct atgaaaataa     1500

cttgatgcct tacaccaatt acacctttga tttcaaaggc gtgattgact acattttcta     1560

ttccaagact catatgaacg tgcttggtgt cctggggcct ttagatcctc aatggctggt     1620

tgagaacaac atcactgggt gtccacaccc tcacatccct tcagaccact tctcactgtt     1680

aacacaactt gaactccacc ctccactcct gcctcttgtc aatggtgttc acttgcctaa     1740

tcggaggtag tggagtactg ccccgccaag acggggatct gttgctatgg acctgtacag     1800

ttgtaaatca aagtatgtag gagtgaagta tggccatcct taagctgctt cttcaggttt     1860

ctttcattat gtgtttgctg taagactttg tacatttttg tgcatattgg tatcatttgg     1920

cagtagggct ggaaccaaag tattactctc tttacaaaat tttaatttaa catgttttta     1980

aattggacct tctttatatt gtattaacag ccagcattca aaattgataa attaccaatt     2040

tgaggcccaa taacagtgta tttgtttttc caaaacaaat actttctttt gaatggtttc     2100

agtgagccaa ccattttata aaaggcaatt tttaaaaact ataaatacag tattttaaac     2160

tgaatgatga tatgccttcc agggaaaacc ttgaattttt cctttataac tgacttttgg     2220

attccaaagt catttgcaca ttaacagagt acttaaattt acttgttcag tccataaact     2280

atgatatagc ctctatacat ggtaagaaaa tttgaaaaat taaagatggt tgcacagtat     2340

acttttataa tccagcatgt aacaccacat gacaatttgt tggccaaatg ctggtttgga     2400

gtttttttga ggaatcactt tggttttttt gtcctttata tataacctta ttggaagtat     2460

taattctaag cctgtctctc aagtttattt atagagaaaa agtaagtaat ctgtattgcc     2520

acataccttg aaaatagaat gtggtatgtt taggatgccc acggaatgaa tttttcctta     2580

ttccaattca accttctgtc tggttgtgcc aggaaaacag atgttatatg acctatgtca     2640

tttttgccat tatagtcaaa tgttaaaaga agaaaaaagt ctgctgaata aaaaggcctt     2700

gatcaaagtt tcagatgggg aaaatcatac agatatttta tgtgtttcca acatagatta     2760

tgtggctgtt ggtttcttga gatgacagtg caaaggattt gggagagaga acaaatttgg     2820

ggcagtagtt gaaaacgttg ggtcattttc ctgactctag ctgccaaatg gccatcatat     2880

gcttttaatc tttgtttcag ttgtctgtca gggttgaatt aagaagctac tggtttattc     2940

ccaattgttg atgcctttag gtatgttgga atcttttttt tgcctaggag gggccagttg     3000

aaaatctgtg actcaagagg cagtgaacag aatactgttt tctggggaaa aattggttgg     3060

ctacttgatg ttaattatgg cacagtaaca ggaaaaggtt gtgtctgtgt ttttaagttt     3120

ttctttattc tgcttttttg ctgctataag agttttctga aatttatatt ttaaactttt     3180

catgcacttt actgtttcta gtctcaaaat gtgatatttt taataaacaa gaaattttcc     3240

attatgtgaa tgaaatttta aaagacaata gcctatattt gtgtctcact aatatataaa     3300

gtataggtca aatttaaatt atttaattag ttttaaatat acacaatttg tctcctcttt     3360

caaacctgac atcttcggct gttttattag tcttaaatga tgcatttact ttggtcattt     3420

tatgctaatt tcttccatag taaattaatc aggctatata aggtaatatt tccccagagg     3480

gtaattttag tgggacgagg gtggtgggat gatgtcatat catacatggg attgcatcag     3540

aagggttctg taaagcctga actccctttt aaaagtgcct agtgatagag gcgttgtttg     3600

tcatctatta taattggaat gtcattgtag ttcagtgaat tttgatgtaa ataaaatatc     3660

ttttaaaaat gttaaagtac caggataaac aaacaaaaag aaacaaccct taagatgaca     3720

gattttcctc aacatgcagg tttcccttct tatatacctc aagtatccaa catctagcca     3780

tgcaaattga ttacctgaag catagtactg gaaagtagaa tagcatgaaa aacttaattt     3840

tgtggacatt accttttttt gtaatcagct actgtatgtt ttattttaga tcttttgttt     3900

tgggtgggtt ttctgctctg gaggtatatg cactaacaaa acattttcct cctttcatat     3960

acgcatgtta attagcaatg tgagcaatat ttcctaccat acttcactcc caatattttt     4020

tgagatgttt gtataaaatg gaatttaaag ttcacttatg attgtatatg aaccacagag     4080

gagcccattt attaataaaa aactttttta atagttaaat gtagagggaa aaaataaaaa     4140

aaaatgggaa acattgtaaa cagcttaagt ttattttgtg tatgatcgag gcactctgtt     4200

gcaggaaggt gtgtaattgg gttctctctg cttcaaatgc gctctttcaa accattcatt     4260

atcctgtgta tttttaatgt ggttttagta aatgttggta gtagctctgt tgaagtaggt     4320

aattgtgtta tgttttgggt ggtacacact tggggcatgg taacccaaat ttcatgtgca     4380

cggtttccct ttagcccact gcccaaattt cacataccct tcaccctttg ttccctttgt     4440

aaaaggagtg gtatctgttt tgagctgcca attcagatga tcagaaatgc tgctttcctc     4500

agcattgtct tgttaaaccg catgccattt ggaactttgg cagtgagaag ccaaaaggaa     4560

gaggtgaatg acatatatat atatatattc aatgaaagta aaatatatat gctcatatac     4620

tttctagtta tcagaatgag ttaagcttta tgccattggg ctgctgcata ttttaatcag     4680

aagataaaag aaaatctggg catttttaga atgtgataca tgttttttta aaactgttaa     4740

atattatttc gatatttgtc taagaaccgg aatgttctta aaatttacta aaacagtatt     4800

gtttgaggaa gagaaaactg tactgtttgc cattattaca gtcatacaag tgcatgtcaa     4860

gtcacccact ctctcaggca tcagtatcca cctcatagct ttacacattt tgatggggaa     4920

tattgcagca tcctcaggcc tgacatctgg gaaaggctca gatccaccta ctgctccttg     4980

ctcgttgatt ttgttttaaa atattgtgcc tggtgtcaac ttttaagcaa cagcactgcc     5040

taaaagcaag cagagaacag aatcccagca ccattctata ggcaactttt tagaattcag     5100

atatagtaaa tctgttccag atttatgatg ttttatgtaa aaaaaatttt gtataataac     5160

atagctgaat atttttgttt catttctttg atgtaaggcg tgtgaacatt cgtttgaata     5220

tcacatgttg aagtcaggta tggcacaatg ggttctgaga ccagcttttc ctcccctccc     5280

atttgccttg ttccaagctc tttcttttca aattactttt ctgatattca taggcaggta     5340

tttaatttta ctaattagca tcctgtgtga atgtattaaa gaagccactg tgttttagtg     5400

tagttggcaa aaatataaaa gctgtttctt atttgcccct atttttttgg tgtcttaaag     5460

ttatatatta aatcacagag aagcaaggga gaaagttgaa agatatctaa ggctcatatc     5520

acttgattct atggtagatt atattagaat tgaggatgtg gcacattaaa actggaacat     5580

gggcaaatat agtgttccat tttaaaattc taagtttata ttgttaaatg ggtgaaaatt     5640

taagtttata tttgcatttc caagcgtttc taaaaatcac taatgccatc tatactttta     5700

gtatgaaaca gcagactata gaaagcacag ggaagaatag gctaaataca ttctttgaag     5760

aaccagaggc atataaccac atcattatgt cattcctaat acatggctag attttctaat     5820

gataaaattg actgtgtccc aatgcttatt tgattctaag cttttttatt ctgtttctga     5880

gatattttaa tagctttgca aaatatgctg accagttttt ggaaaataat ggtttttata     5940

gcaagcaaag actttatggc acattttcaa aatagcactc atacatactt acattttgac     6000

agaaatgtga attctcacat tgatgagata ttctttttcc cacctgccct accctttaaa     6060

aaaggtcact tttctaatgt gtagtagatt catttacgcc tttccctttg agtcatacca     6120

tgtttggaga actgtgtgaa ttgtaggtag agaaattaac tagggaagcc agaagcttga     6180

actaaagttt taaatttgta ggcagatgag aacttttata ctatggttgc tttgggcgat     6240

tctaattttg taatagcatc atgatcacca aaattaattc aaacatttta gtacatcttt     6300

aatctgtctt atttaccaaa gttctaatct gtttaagaac aggatgccaa gagcatcttt     6360

cattttatag aatgatatgc tcacctttat aagtgtcacc taaaagcttg agggtaaaaa     6420

agaagcagcc catatatcta aactacagga tgtcttgaac aagattcaca gaaagaaaga     6480

aaaaaaagca gttctttcca ggaaggtggt aaggaagagc atgcatattt cttgttttaa     6540

ccaaatacct tttttatgta aatgtctcta ttaaacccca ggtcctacac caggaaatag     6600

ggtgataacc aggaaaatac caagctttaa cccagttggc agttccttgt ggcatacatt     6660

tggttagact tgggtttttc ctggaaccaa aggaaaataa gcatgttgag ttcttcgttc     6720

aacagacatg acattgaagt aatagaatat tttttaagta aaatagtttt cactttcaaa     6780

gcctatgaca taaggacatt tgtgcttatt aattgttaat ttttttttat ggtacattgt     6840

ataaactgag tagcattgaa ctgcatttta gaagtatgtc atcagaaaca aatcacatta     6900

tggaaaggat atacaaatgc caagtgatat gactcttttg gcatggtggt agcatggtcc     6960

attcagcttt cagaatcttt cggaggctct agtttggtgc ctagtactag ttatttttgt     7020

tagaacaatc tctcaaaatt tagataattt tccagttgta tgtctgtcac ttttaactct     7080

aaagcgtaag aatcatggta accctctcag aagtggtcct ttcttgctca tttcagtttc     7140

gtattaactt caaatcactg atgtattgtc tttcaagcta tcaattgtta tatgtaccaa     7200

tttaatttag tttgtagtta tctgaagtca caaaattggt tcagcattga tgtcaaacaa     7260

tggctttgct tcttaccaaa cagacttagt atcctgctgc ttgtttcaat cttgatgcag     7320

taagtgatgc agtatctggg tctgtattta cttagaaact gtactgtcct ttctctgtgc     7380

ttaacttgct aaaaatatat tcccttacct gtgaaattcc tgagcggtgc tctgccaact     7440

tttcaagggg agggatttgg atggctgtgt tactgcacac tggatctgga attgttcagg     7500

gttatgagtg acaaatttct taaacaccag cagcactgag atgtgcacta tgggcattcg     7560

tacagttgtt gtccaaatgc aaacaacttt ttcatcttgg agaagctgag atacagagtt     7620

caatagaact acttggaata ttttgagaag gttgaatgtt tcatctttgg ctttgttgtc     7680

tctggagtgg ggaagtatgg agggcttttt tttttttttt tttttttttt tttttttttt     7740

ttaaagagag tgtgtatgta ctttttctct ctataagggc cagggtgttg gtcaaattca     7800

ccatcgatta atttatatct tctgttgtga tttttttcaa ctatataaca agtgccaact     7860

aattgtccat gggacaatct acttttccac tcaatttatc gttttgagta gggaaaggtt     7920

catttatttt cattacctgg cattaagtta aagaattcat tattttgcat acatttgagt     7980

cattctgtga cctataaagt gtttttgtaa ctatctaatt ctaatggttg caaagcaaag     8040

cacatgactg taaaaccaag caaggtgttt tagtaacttt ttccctgaat acttggtagt     8100

ttccattgat actattccaa aacaaattct gctgttttag gttgtatatt tactttgctt     8160

ttgttctaag aaaaagccaa ggactaaatc aacttgtttt tgtgtttcag taatcagttt     8220

aaaatctaag attttttttt aaattagact atttaatgaa gtgccatgta attgtagctt     8280

gctagtgttt aatgtttaat agactggttc tgtaggtgtt ttaaccattt aacactctct     8340

gccatccctg gagaaagtgg ttctactctt actgaacaca ttctctctga caaaatcacc     8400

agctgcttta tttttctatt tattacagtt aaacagttga tgaggtctga atcttgacca     8460

aaactgctca gctgagatgt ttttcacaat agacactgta caaagtgtgc gtgcaaaagg     8520

acacggttgg tagtattttt tcattaatgt gaacattgac taaaaaaaag cagtcctgcc     8580

ttttaaatct tgtggcagct cagaagggag gtgcttaaga accttaacta ctatgtcaga     8640

taacaaaata tttttttcca ttttggagat tggttactgc tcacacatga tgtatagggc     8700

taaatatatg cttgtttcct tgcacctgtg tacttcccct ctctccctcc ctttccttcc     8760

cctgtaggca ataaatggcc attttgcaac tgca                                 8794


<210> 445
<211> 3589
<212> DNA
<213> Homo sapiens

<400> 445
agttcagatt ctgaaataat aggttatgct ttggacacac tatataatat aatatctaat       60

gaagaagaag aagaagtaga agaaaattcc acaagacaga gtgaagattt gggaagccaa      120

tttacagaaa ttttcattaa gcagcaggaa aatgtcactc ttctgttatc tttattggag      180

gagtttgatt tccatgtccg ctggcctggt gtgaagcttc ttacttctct tttaaaacaa      240

ctagggcctc aggtgcaaca aattatttta gtcagtccta tgggtgtttc aagattgatg      300

gacttactag cggattccag ggaagttata cgtaatgatg gcgtcttact actgcaggca      360

ctaacaagaa gcaatggtgc aatccagaaa attgttgctt ttgaaaatgc tttcgagaga      420

ctactggaca ttatttcaga ggaggggaac agtgatggag gtatagtagt tgaagattgt      480

ttgattttgc tccaaaactt attaaaaaac aacaactcca atcaaaattt ttttaaagaa      540

ggctcatata ttcaacgtat gaaaccttgg tttgaagttg gagatgaaaa ttctggctgg      600

tctgcacaga aagtgaccaa tctacatcta atgctacagc ttgttcgtgt attggtatct      660

cccaccaacc ctcctggtgc taccagtagc tgccagaagg ctatgttcca gtgtgggtta      720

ttgcagcagc tttgtactat cctaatggct actggggttc ctgctgatat cctgactgag      780

accataaata ctgtatcaga agttattcga ggctgccaag taaaccaaga ctactttgca      840

tctgtaaatg caccttcaaa cccaccaaga ccggcaattg tagtacttct catgtccatg      900

gttaatgaaa ggcagccatt tgttttgcgc tgtgctgttc tctattgttt ccagtgtttc      960

ttgtataaaa accaaaaagg acaaggagaa atcgtgtcaa cacttttacc ttctaccatt     1020

gatgcaacag gtaattcagt ttcagctggc cagttattat gtggaggttt gttttctact     1080

gattcacttt caaactggtg tgctgctgtg gcccttgccc atgcgttgca agaaaatgcc     1140

acccagaaag aacagttgct cagggttcaa cttgctacaa gtattggcaa ccctccagtt     1200

tctttacttc aacagtgcac caatattctt tcacagggaa gcaaaataca aacaagagtt     1260

ggattattaa tgttgctttg tacctggcta agcaattgtc ccattgcagt aacgcatttt     1320

cttcacaatt cagccaatgt tccatttctt acaggacaaa ttgcagaaaa tcttggagaa     1380

gaagagcagt tggtccaagg cttatgtgcc cttttgttgg gcatttcgat ttatttcaat     1440

gataactcac ttgagagcta catgaaagag aagctaaaac aactgattga gaagaggatt     1500

ggcaaagaga atttcataga gaaactagga tttattagca aacatgagtt gtattccaga     1560

gcatctcaga aaccccagcc aaactttccc agtccagaat acatgatatt tgatcatgag     1620

tttacgaagc tggtaaaaga acttgaaggt gttataacta aggctattta taagtccagt     1680

gaagaagata aaaaagaaga agaggtgaaa aaaacattag aacagcatga caatattgtg     1740

actcactaca aaaatatgat tcgagagcag gatctccaac ttgaggaatt aaggcagcag     1800

gtttctacat taaaatgtca aaatgaacag ctccagacgg cagtcacaca gcaagtatca     1860

cagatccagc agcacaaaga ccagtataat cttcttaaaa tacagctagg aaaagacaat     1920

cagcatcaag gttcttacag tgagggggct cagatgaatg gcattcagcc agaagaaatt     1980

ggtagattgc gagaagagat agaagaatta aaacgtaatc aggaactttt acaaagccag     2040

ctgactgaaa aggactctat gattgaaaat atgaaatctt cccaaacatc tggcacaaat     2100

gaacagtctt cagcaatagt ttcagctaga gattctgaac aagttgcaga attaaaacag     2160

gaactggcaa ctttaaagtc tcagttaaac tcacaatctg tggagatcac caaactacag     2220

acagaaaagc aggaactgtt acagaaaaca gaagcgtttg caaaatcagt tgaggtacaa     2280

ggagagaccg agactataat agccaccaaa actactgatg tagaaggaag actgtcagca     2340

ttattacaag agaccaaaga gttaaagaat gaaattaaag ctctgtctga ggaaagaact     2400

gccattaaag agcagctgga ttcatctaat agtaccattg ccattttaca aactgagaaa     2460

gacaaactag agttggaaat tacagattct aaaaaagaac aagatgatct cttggtgctc     2520

ttggccgatc aagatcagaa aatactgtca ttgaagaata aactcaagga tcttggtcat     2580

ccagttgaag aagaggatga acttgaatct ggagaccaag aggatgagga tgatgaaagt     2640

gaagatcctg gcaaggatct agatcatatc tagttttcaa atctctagga acaatagaga     2700

ttatatcata actctgaaga tggactctaa actttggttt acctccatgg aaaataaaga     2760

tttagaaacc aggtggaaaa cattcactat taagactatt gatatatttt tgtaatgttg     2820

ccacccatgt tgaaaacctt aaaactgaat ttatgtagaa cacacatctt ttatttaaat     2880

ccatctgaac tgtcccaaaa tgtaatttgc aaagagcttc aaacaccaaa aatataccat     2940

tttaaggcat gtggtgacaa tgctatttgc cttagttcat tcgttgttta ctttgcaaaa     3000

tttgtgactt ttaagtacta acacatttga ttgaatgtgt attgaattgg aattattatt     3060

tctaaattca gcatttgagt ccttagttga tgattttctt ttaaagaaat tagtttattt     3120

aaaagcaaga tagcctgggt tgggagttag tgcatatcat cagccctcca tctaatgtga     3180

ttgctaagat gtgcaggata ggacagctta gaatgagtgc cttgacacct acatatggct     3240

gcattccata cctcagtgaa gaagccgaag gatgctgaca cacagtgatg tggagggcat     3300

tccggagaaa cttttgcaac agtgtattaa tgtgattggt tttctttttg ttttaagcta     3360

aacatctaaa acaaatttca agttaacagt tcatacaact cagatttagt agtattgttt     3420

atcataaaac atattatgtt cctagtttta aaaagaccca aagtatgatt aatataattt     3480

attggcattt ttgctgaata ggtttaagtc agataataga ttttaaaaaa gcaaatgagg     3540

caatgtgtca aaatttaatg tttcataata aaaatagata cgttgactt                 3589


<210> 446
<211> 2434
<212> DNA
<213> Homo sapiens

<400> 446
ggctctcggt tctgccgacg caggtcccgc ccctctcgta gcctcgcccc gcccgccgcg       60

caggcgccgt ccgagggctc cgtttgaaac atggcgcggg ctggccctcg gctggtgctg      120

agcgaggagg cggttcgggc gaagagcggc ttagggcctc accgcgacct ggctgagctt      180

cagtcattgt ctattcctgg aacttaccaa gagaagatca cccacctggg acattctctg      240

atgagtttaa caggtctgaa atctttggat ctctcgcgca actccttggt tagtctggag      300

ggcattcagt acctgactgc attggagagt ctcaatctct actacaactg catctcctcg      360

ttggcagaag tgtttcggct ccacgcctta accgagctcg tggatgtgga cttccggctg      420

aaccccgtgg tgaaggttga gcctgactac cgcctttttg ttgtgcacct gctccccaag      480

ctccagcagc tggacgatcg ccccgtgaga gcaagcgagc ggaaggcttc ccgactgcat      540

tttgcatcag aggactcact cgactccaaa gagagcgtcc cagcttcttt gaaagagggc      600

agaccacacc accccagagc caagtgcacc gaggccttgg ccaagcagag cctggtcatg      660

gatgcggatg acgaggcagt cctgaacctc attgcagagt gcgagtggga cctcggcagg      720

cctcccggga gcacgagctt cagccagaag gggcgtgagg ccgactctcg tggttcccaa      780

gaatccagac atctgttgag cccgcagttg gtacagtacc agtgtgggga ctctgggaag      840

cagggccgtg agacgaggag gagcagctgc agagggtgct gtctggagaa gatgccttgg      900

agccagctct gtggagagct tccgccactg tacggagcgg agccagaggc ctcccgtgcc      960

cccaggccac acacgtactt caccccacac ccagactcca tggataccga ggactcggcc     1020

tcttctcaga agttggattt gtcaggagaa atggtgcctg gtcccctgcc agcccccgga     1080

aagtgcagga agcgaagaat gcctgttgga agattccaga cgttttcgga ccaggagggt     1140

ttgggctgcc cggagagaac tcatgggtcc tccgtgccca aggagagcct gagcagacag     1200

gacagctcag aaagcaggaa cgggaggacc ttgtctcagc ctgaggcctc ggagactgag     1260

gagcagaggt ctcggggtgt gaccgacacc agagagccgt ctcccgggtc acactcggct     1320

ctacccggga agaagacggc cctgcaggcg gcgctcctgg agacgctctt ggacctggtg     1380

gacaggagct ggggcggctg caggtccctg cacagcaacg aggcattcct tgctcaggca     1440

agacacatct tgtcatctgt tgaagaattc acagcagctc aggacagctc tgcgatggtg     1500

ggtgaagatg tcggctccct ggctctggag agtaagtccc tgcaaagccg ccttgctgag     1560

cagcagcagc agcacgcccg ggagatgagc gaggtgacgg cggagctgca ccacacacac     1620

aaggagctgg atgatttgag acaacattta gataaatctt tggaagagaa cagtaggtta     1680

aaatcgcttt tgttgagtat gaaaaaggaa gtgaagagtg cagacactgc agccacgtta     1740

aatttgcaga tcgctggact tcaaacaagt gtgaagaggc tgtgtggcga gattgtggaa     1800

ctgaagcagc acctggagca ctacgacaag atccaggagc tcacgcagat gctgcaggag     1860

agccacagct ccctggtcag caccaatgaa cacctgctgc aggagctgag ccaggtgcgg     1920

gcgcagcaca gagccgaggt ggagcagatg cactggagct accaggagct caagaagacc     1980

atggccctgt ttccacacag cagcgccagc catggaggct gccaggcctg ctgactcctg     2040

ccgagaagct gggccacccc ttaagcttcc tggtaaagtt acattgtctg cacctttgta     2100

cttctttatt gagtgtactg gctggcaaga gttctctctt ctgttggtaa ttatttagga     2160

tttttggaat gtattcagga cctgtagctt ggttttctaa agcacctcgt aaaatgatat     2220

gattactcca agccctctgc atgttttcag acagaacaca ttgacatatt ttgagacaaa     2280

ctgactatta atcttgtatc cagtatcctg agatgaagta aatgcagtgt tctactgcct     2340

gatgtgaaag agagctatgt atgataatta aagaaaataa ttttctgtgt aacaagcaat     2400

ctttatttaa taaacaaata cattgttctg aaaa                                 2434


<210> 447
<211> 3307
<212> DNA
<213> Homo sapiens

<400> 447
ctggctcgcg cgtgcctttt cccctcaggt tgtggggaga gcggaatcct gctccgccgt       60

cgcagcagca gcggcagccc cggcagcctc gggcgacagc ggcggcgcgc gagcccccgg      120

gcggaccgta ccaccgctcg ccagcacgca gggggagccg cccgtctcgc cgcgcacgcc      180

tcggcgaccc cgcggggctg aggcgtcgcc gcgcccggca gcgtgagcgc agagccggcc      240

tcgaccccga gctcggagcc ccgcgggccg cgcccgccgc cggccccacc catccgggtc      300

gaggaggccg aggccatggc tgagacggag gagcggagcc tggacaactt ctttgccaag      360

agggacaaga agaagaagaa ggagcggagc aaccgggcgg cgagtgccgc gggcgcagcg      420

ggcagcgccg gcggaagcag tggagccgcg ggtgcggcgg gcggcggggc gggcgcgggg      480

acccggccgg gtgacggcgg gaccgccagc gcgggggctg cgggcccagg ggccgccacc      540

aaggctgtga cgaaggacga agatgaatgg aaagaattgg agcaaaaaga ggttgattac      600

agcggcctca gggttcaggc aatgcaaata agcagtgaaa aggaagaaga cgataatgaa      660

aagagacaag atccaggtga taactgggaa gaaggtggag gtggtggtgg aggtatggaa      720

aaatcttcag gtccctggaa taaaacagct ccagtacaag cacctcctgc tccagtaatt      780

gttacagaaa ccccagaacc agcgatgact agtggtgtgt ataggcctcc tggggccagg      840

ttaaccacaa caaggaaaac accacaagga ccaccagaaa tctacagtga tacacagttc      900

ccatccctgc agtcaactgc caagcatgta gaaagccgga aggataaaga aatggagaag      960

agctttgaag tagtaagaca caaaaataga ggtagggatg aggtttcaaa aaaccaggcc     1020

cttaaacttc agctagacaa ccaatatgct gtgcttgaaa atcagaaaag cagccactca     1080

caatacaatt aaggaatggg ctttgctaac ccttctgagg taactagact gcagctaacc     1140

accaccaaca gccattcatc atctgatctc tgctggatct acagacaccg atgcagacca     1200

ctcgatttca tgaccggccc tattgcacta tggaagttaa agtgtcacga ctgctctatg     1260

catattggat ttaggggaat tttcattgtt acataaatgt gtgaactagt ttcaacagtg     1320

ttctttcata tttactctgc aaatacaaaa aaccaaaacc tgcagccagt ggtcatttca     1380

aaatcttttt atgttcagat actgagcctt cataagggtt gactacctca gatttgctgc     1440

actcattgtg gacttcatgt ggatcacaac ttctggataa gaagattaca actattaagt     1500

gtcgatgtga accttgcaac cagctctact ggattcttat cagaaatcct gcataaaaag     1560

tcagccatct gggttctgat ctgctgtaaa agatgaagat ttaagtgacc ttaattaacc     1620

tgtcctgtgc cctaccctta aggaatactc tctgtagtag gctgttgtta tattagactt     1680

cctggaacac actgctgaaa agaactgatg tgttcagatc atctgtgtag ggctgtgatt     1740

tgtaatttaa actaattgta ttctgaggta accacaaaat aaattcaacc aaactggggt     1800

ccaccaagtg ggggaagggg aagggagaga ataatcttgg gggttttttt tttttggtaa     1860

tttttttatt tggatagtgc ttttttgttt tgtttttgtt ctgcattaag gccttttttg     1920

ctttgacttg aaataagttc tttgacagag catattgctt ggttaattaa gtaacctaaa     1980

gtatgcatta ggattgtgaa atgtctcgtg agtatgccaa tcctgagggt ggaaccaaat     2040

agcctttgat gaaaagggca gtggattctg gaggctctac ttcaggtgct gctataatgc     2100

ctcatctaat caggactaaa ttgtgtagga aactgcagtg ggaagaatat gctttctgct     2160

caggctaaga gggtcactga tctgtcctta gaaattcaga gtaacatgag caaaacctca     2220

gctaaaaccc atttaagtgg catggattgt gcatgatctt tgataagaat tcctcatgta     2280

cttgtgccta gtttttcaag gtattggctg ttctatagat gcagtgattg tcccagctag     2340

ctctgttacc agccttttgg tgtgtcttta tgttcatttg gagagtcagg gcgaaagaca     2400

ggtgatgtag cacttctgtt tttaataatt attgcttaaa atacctatta atagttttgg     2460

gtcatttaaa gggacttgag gaagctaccc aggattacag aagagtgtcc acctaacaag     2520

atggtctggc agtttcctag ttttgtatct ggttcaatag aaatatgtga aagtggtaat     2580

gtcatcattt gatgcagagt ccgggtttct ctataataaa tccctttgcc aaatgcatga     2640

gttgcagact tgctactggc aagagtgaag caagtgggtg agtaaaacta ttttgacgtg     2700

ggagcgtttt cagataggag tttagtcttg acgaaagtgt ccgtgcagga attggactcc     2760

gaggagggtt acagtatctc ctgacgggac ctgccactcg catctgggca atgttgacat     2820

ttgaggtggc aggcaggatg cctgccttct aatatatttg ggtgagtaac tgagccagcc     2880

aagggaaggt tgaatgatta aatcagaaat gggattcttg gtaaactgaa gacttttatt     2940

tgggaatgaa aaaccttaaa aaaatctctt catcgttgaa ctgtgcattt tccctgcatt     3000

ttttcccaac aaaattttgt tgggggttat gttactgaag aatgaacaga tgagtaagtg     3060

gaggtgttat gtaaaggcat attgtactcg aaatctgaag acctgcagca gatttaaatt     3120

acaactcttg ttataacttt ttaaaagatt gtgaaaatat caaaatataa atgaatcaag     3180

ttttaatata ctgtatgatg ggtggatgag gctgtccatt gtaccatttg tttgaattct     3240

caggcatggt ttggcagtgc aagaattctg taacattaac aaattcaata aaaagtaaat     3300

atatgga                                                               3307


<210> 448
<211> 1688
<212> DNA
<213> Homo sapiens

<400> 448
ttggctctcg cctaccgggg gcttctctca ccgggactcg ggactcccgg gaagtggacc       60

ggcagaagag ggggctagct agctgtctct gcggaccaag gagacccccg cgcccccccg      120

gtgtgaggcg gcctcacagg gccgggtggg ctggcgagcc gacgcggcgg cggaggaggc      180

tgtgaggagt gtgtggaaca ggacccggga cagaggaacc atggctccgc agaacctgag      240

caccttttgc ctgttgctgc tatacctcat cggggcggtg attgccggac gagatttcta      300

taagatcttg ggggtgcctc gaagtgcctc tataaaggat attaaaaagg cctataggaa      360

actagccctg cagcttcatc ccgaccggaa ccctgatgat ccacaagccc aggagaaatt      420

ccaggatctg ggtgctgctt atgaggttct gtcagatagt gagaaacgga aacagtacga      480

tacttatggt gaagaaggat taaaagatgg tcatcagagc tcccatggag acattttttc      540

acacttcttt ggggattttg gtttcatgtt tggaggaacc cctcgtcagc aagacagaaa      600

tattccaaga ggaagtgata ttattgtaga tctagaagtc actttggaag aagtatatgc      660

aggaaatttt gtggaagtag ttagaaacaa acctgtggca aggcaggctc ctggcaaacg      720

gaagtgcaat tgtcggcaag agatgcggac cacccagctg ggccctgggc gcttccaaat      780

gacccaggag gtggtctgcg acgaatgccc taatgtcaaa ctagtgaatg aagaacgaac      840

gctggaagta gaaatagagc ctggggtgag agacggcatg gagtacccct ttattggaga      900

aggtgagcct cacgtggatg gggagcctgg agatttacgg ttccgaatca aagttgtcaa      960

gcacccaata tttgaaagga gaggagatga tttgtacaca aatgtgacaa tctcattagt     1020

tgagtcactg gttggctttg agatggatat tactcacttg gatggtcaca aggtacatat     1080

ttcccgggat aagatcacca ggccaggagc gaagctatgg aagaaagggg aagggctccc     1140

caactttgac aacaacaata tcaagggctc tttgataatc acttttgatg tggattttcc     1200

aaaagaacag ttaacagagg aagcgagaga aggtatcaaa cagctactga aacaagggtc     1260

agtgcagaag gtatacaatg gactgcaagg atattgagag tgaataaaat tggactttgt     1320

ttaaaataag tgaataagcg atatttatta tctgcaaggt ttttttgtgt gtgtttttgt     1380

ttttattttc aatatgcaag ttaggcttaa tttttttatc taatgatcat catgaaatga     1440

ataagagggc ttaagaattt gtccatttgc attcggaaaa gaatgaccag caaaaggttt     1500

actaatacct ctccctttgg ggatttaatg tctggtgctg ccgcctgagt ttcaagaatt     1560

aaagctgcaa gaggactcca ggagcaaaag aaacacaata tagagggttg gagttgttag     1620

caatttcatt caaaatgcca actggagaag tctgttttta aatacatttt gttgttattt     1680

ttttcatg                                                              1688


<210> 449
<211> 2244
<212> DNA
<213> Homo sapiens

<400> 449
gtctcgtgac aggtacttcc gctcggggcg gcggcggtgg cggaagtggg agcgggcctg       60

gagtcttggc cataaagcct gaggcggcgg cagcggcgga gttggcggct tggagagctc      120

gggagagttc cctggaacca gaacttggac cttctcgctt ctgtcctccg tttagtctcc      180

tcctcggcgg gagccctcgc gacgcgcccg gcccggagcc cccagcgcag cggccgcgtt      240

tgaaggatga cctctaggaa gaaagtgttg ctgaaggtta tcatcctggg agattctgga      300

gtcgggaaga catcactcat gaaccagtat gtgaataaga aattcagcaa tcagtacaaa      360

gccacaatag gagctgactt tctgaccaag gaggtgatgg tggatgacag gctagtcaca      420

atgcagatat gggacacagc aggacaggaa cggttccagt ctctcggtgt ggccttctac      480

agaggtgcag actgctgcgt tctggtattt gatgtgactg cccccaacac attcaaaacc      540

ctagatagct ggagagatga gtttctcatc caggccagtc cccgagatcc tgaaaacttc      600

ccatttgttg tgttgggaaa caagattgac ctcgaaaaca gacaagtggc cacaaagcgg      660

gcacaggcct ggtgctacag caaaaacaac attccctact ttgagaccag tgccaaggag      720

gccatcaacg tggagcaggc gttccagacg attgcacgga atgcacttaa gcaggaaacg      780

gaggtggagc tgtacaacga atttcctgaa cctatcaaac tggacaagaa tgaccgggcc      840

aaggcctcgg cagaaagctg cagttgctga gggggcagtg agagttgagc acagagtcct      900

tcacaaacca agaacacacg taggccttca acacaattcc cctctcctct tccaaacaaa      960

acatacattg atctctcaca tccagctgcc aaaagaaaac cccatcaaac acagttacac     1020

cccacatatc tctcacacac acacacacac gcacacacac acacacagat ctgacgtaat     1080

caaactccag cccttgcccg tgatggctcc ttggggtctg cctgcccacc cacatgagcc     1140

cgcgagtatg gcagcaggac aagccagcgg tggaagtcat tctgatatgg agttggcatt     1200

ggaagcttat tctttttgtt cactggagag agagagaact gtttacagtt aatctgtgtc     1260

taattatctg atttttttta ttggtcttgt ggtcttttta cccccccttt cccctccctc     1320

cttgaaggct accccttggg aaggctggtg ccccatgccc cattacaggc tcacacccag     1380

tctgatcagg ctgagttttg tatgtatcta tctgttaatg cttgttactt ttaactaatc     1440

agatcttttt acagtatcca tttattatgt aatgcttctt agaaaagaat cttatagtac     1500

atgttaatat atgcaaccaa ttaaaatgta taaattagtg taagaaattc ttggattatg     1560

tgtttaagtc ctgtaatgca ggcctgtaag gtggagggtt gaaccctgtt tggattgcag     1620

agtgttactc agaattggga aatccagcta gcggcagtat tctgtacagt agacacaaga     1680

attatgtacg ccttttatca aagacttaag agccaaaaag cttttcatct ctccaggggg     1740

aaaactgtct agttcccttc tgtgtctaaa ttttccaaaa cgttgatttg cataatacag     1800

tggtatgtgc aatggataaa ttgccgttat ttcaaaaatt aaaattctca ttttctttct     1860

tttttttccc ccctgctcca cacttcaaaa ctcccgttag atcagcattc tactacaaga     1920

gtgaaaggaa aaccctaaca gatctgtcct agtgatttta cctttgttct agaaggcgct     1980

cctttcaggg ttgtggtatt cttaggttag cggagctttt tcctcttttc cccacccatc     2040

tccccaatat tgcccattat taattaacct ctttctttgg ttggaaccct ggcagttctg     2100

ctcccttcct aggatctgcc cctgcattgt agcttgctta acggagcact tctccttttt     2160

ccaaaggtct acattctagg gtgtgggctg agttcttctg taaagagatg aacgcaatgc     2220

caataaaatt gaacaagaac aatg                                            2244


<210> 450
<211> 4738
<212> DNA
<213> Homo sapiens

<400> 450
agtgcggtcg gaggcggcgg tctgttctcc gctgaggagg agcggggcag aggagggagg       60

cagcgggtga gagttcagag ttcagcagca gcagcccgag cccatgattc ccatatgccc      120

tgtagtttct ttcacctatg tgcccagccg gctgggggaa gatgccaaaa tggcgaccgg      180

caactacttt ggattcaccc acagcggggc ggcggcggcg gcggctgcgg cccaatatag      240

ccagcagcca gcttcgggtg tagcctattc tcatccaact acagttgcta gctacactgt      300

ccatcaggct ccagtagctg ctcacacagt tactgctgcc tatgcaccag cagccgccac      360

agttgcagtt gccaggcctg ctccagtagc tgttgcagct gctgcaacag ctgctgctta      420

tggaggctac cccactgcac acacagcaac tgactatggt tatactcaga ggcaacaaga      480

agcaccacca ccaccacccc cagctactac acaaaactac caggattcat actcatatgt      540

aaggtccaca gctcctgctg tagcttatga tagtaagcaa tactaccaac aaccaacagc      600

aactgctgct gctgtagctg ccgctgccca acctcagcct tctgttgctg aaacttacta      660

tcagacagcc cccaaagcag gttacagcca aggtgcaact cagtatactc aagcccagca      720

aactcgacaa gtgacagcca taaaaccagc cacaccaagt ccagctacca ctactttctc      780

catctatcct gtatcctcca ccgtacagcc agtagcagct gcggctactg tggtgccatc      840

ctatactcag agtgctactt acagtaccac agcagttaca tattctggta cgtcttattc      900

aggttatgaa gcagcagtgt attcagctgc atcttcctac tatcaacagc agcagcagca      960

acagaagcag gcagcagcag cagctgctgc tgctgctgca acagctgcct ggacagggac     1020

cacctttact aaaaaagcac cattccaaaa taaacaactg aaaccaaaac agcctcccaa     1080

accaccacag attcactatt gtgatgtttg taagatcagc tgtgctggac cacagactta     1140

taaagaacat ttagaaggac agaaacataa aaaaaaagaa gctgcattga aagcctcaca     1200

aaataccagc agcagcaaca gttctactcg tgggactcaa aatcagctac gttgtgagct     1260

ctgcgatgtg tcttgtacag gagcagatgc gtatgctgcc cacattcgtg gtgctaagca     1320

tcagaaagtg gttaagttac acacaaaact tggtaaaccc attccatcaa cagaaccaaa     1380

tgttgttagc caagctactt cttcaacagc tgtatctgct tcaaagccga ctgcctctcc     1440

ttcaagcatt gcagcaaaca attgtactgt gaatacgtca tcagttgcaa cgtcttcaat     1500

gaagggtctt acgactacag gaaactcgtc tcttaatagc acatctaaca ctaaagtatc     1560

agcagtgcct acaaatatgg ctgccaagaa aacatctacc cccaaaataa attttgttgg     1620

tggtaataag ctgcagtcaa caggaaataa agcagaagac ataaaaggaa ccgaatgtgt     1680

taaaagtact cctgtcactt ctgctgtgca gattcctgaa gtaaagcaag acacagtgtc     1740

agaaccagtc acacctgcat ctcttgctgc tttacagagt gatgtgcagc cagtgggcca     1800

tgattatgtg gaagaggtac gaaatgatga aggaaaagta attcggttcc attgtaaatt     1860

atgcgagtgc agctttaatg atcccaatgc taaggagatg cacttaaaag ggcgaagaca     1920

cagacttcaa tataaaaaaa aagtaaatcc agatttgcaa gtagaagtaa agcctagtat     1980

tcgagcaaga aagattcaag aagagaaaat gaggaagcaa atgcagaagg aggagtactg     2040

gcgaagacga gaagaagagg agcgttggag aatggaaatg agacgttatg aagaggacat     2100

gtactggagg agaatggagg aagaacaaca tcattgggat gatcgccgcc gaatgccaga     2160

tggaggttat cctcatggtc ctccaggccc attaggcctt ctgggagtcc gaccaggcat     2220

gcctcctcag cctcaggggc ctgcaccctt acgtcgtcct gactcatctg atgaccgtta     2280

tgtaatgaca aaacatgcca ccatttatcc aactgaagag gagttacagg cagttcagaa     2340

aattgtttct attactgaac gtgctttaaa actcgtttca gacagtttgt ctgaacatga     2400

gaagaacaag aacaaagagg gagatgataa gaaagaggga ggtaaagaca gagctttgaa     2460

aggagttttg cgagtgggag tattggcaaa aggattactt ctccgaggag atagaaatgt     2520

caaccttgtt ttgctgtgct cagagaaacc ttcaaagaca ttattaagcc gtattgcaga     2580

aaacctaccc aaacagcttg ctgttataag ccctgagaag tatgacataa aatgtgctgt     2640

atctgaagcg gcaataattt tgaattcatg tgtggaaccc aaaatgcaag tcactatcac     2700

actgacatct ccaattattc gagaagagaa catgagggaa ggagatgtaa cctcgggtat     2760

ggtgaaagac ccaccggacg tcttggacag gcaaaaatgc cttgacgctc tggctgctct     2820

acgccacgct aagtggttcc aggctagagc taatggtctg cagtcctgtg tgattatcat     2880

acgcattctt cgagacctct gtcagcgagt tccaacttgg tctgattttc caagctgggc     2940

tatggagtta ctagtagaga aagcaatcag cagtgcttct agccctcaga gccctgggga     3000

tgcactgaga agagtttttg aatgcatttc ttcagggatt attcttaaag gtagtcctgg     3060

acttctggat ccttgtgaaa aggatccctt tgataccttg gcaacaatga ctgaccagca     3120

gcgtgaagac atcacatcca gtgcacagtt tgcattgaga ctccttgcat tccgccagat     3180

acacaaagtt ctaggcatgg atccattacc gcaaatgagc caacgtttta acatccacaa     3240

caacaggaaa cgaagaagag atagtgatgg agttgatgga tttgaagctg aggggaaaaa     3300

agacaaaaaa gattatgata acttttaaaa agtgtctgta aatcttcagt gttaaaaaaa     3360

cagatgccca tttgttggct gtttttcatt cataataatg tctacattga aaaatttatc     3420

aagaatttaa aggatttcat ggaagaacca agtttttcta tgatattaaa aaatgtacag     3480

tgttaggtat tatttgaatg gaaagacacc caaaaaaaaa aatgtgctcc gactaggggg     3540

aaaacagtag ttccgatttt ttcccattat ttttatttta ttttctggtt gccctagctt     3600

ccccccctat ttttgtgtct tttattaact agtgcattgt cttattaaat cttcactgta     3660

tttaatgcag gatgtgtgct tcagttgctc tgtgtatttt gatattttaa tttagaggtt     3720

ttgtttgctt tttgacacta gttgtaagtt actttgttat agatggtatc ctttacccct     3780

tcttaatatt ttacagcagt acgttttttt gtaacgtgag actgcagagt ttgtttttct     3840

atatgtgaag gattacaaca caaaaagtta tcctgccatt cgagtgctca gaactgaatg     3900

tttctgcaga tcttgtggca tttgtctcta gtgtgatata taaaggtgta attaagacag     3960

agttctgtta atctaatcaa gtttgctgtt agttgtgcat tagcagtata aaagctaata     4020

tatactatat ggtcttgcaa cagttttaaa gcctctgcat aattgataat aaaaatgcat     4080

gacattcttg tttttaatag acttttaaaa tcataatttt aggtttaaca cgtagatctt     4140

tgtacagttg actttttgac atagcaaggc caaaaataac tttctgaata tttttttctt     4200

gtgtataagt ggaaagggca tttttcacat ataagtgggc taaccaatat tttcaaaaga     4260

acttcatcat tgtacaacta acaacagtaa ctagccctta attatggtga cagttcctta     4320

ttggtgtgtg tgagattact ctagcaacta ttacagtata acacagatga tcttctccac     4380

acaccccatc acccagataa tttacagttc tgttaacagt gaggttgata aagtattact     4440

gataaaaaat tatctaagga aaaaaacaga aaattatttg gtgtggccat cttacctgct     4500

tatgtctcct acacaaagct aaatattcta gcagtgatgt aatgaaaaat tacatcttac     4560

tgttgatata tgtatgctct ggtacacaga tgtcattttg ttgtcacagc actacagtga     4620

aatacacaaa aaatgaaatt catataatga cttaaatgta ttatatgtta gaattgacaa     4680

cataaactac ttttgctttg aaatgatgta tgcttcagta aaatcatatt caaattta       4738


<210> 451
<211> 722
<212> DNA
<213> Homo sapiens

<400> 451
acttccggcc ctgcgcactc agggtctgag gcagctagta gccggagggt caccatgaag       60

ttcaatccct tcgttacctc ggaccgcagt aaaaaccgca aacgtcactt caatgccccc      120

tcacacgtgc gcaggaagat catgtcatcc ccgctctcca aggagctgcg gcagaagtac      180

aatgtccgct ccatgcccat ccgcaaggac gacgaggtcc aggtagttcg aggacactac      240

aaaggtcagc aaattggcaa ggtagtccag gtgtacagaa agaaatatgt catctacatc      300

gagcgggtgc agcgtgagaa ggccaacggc acaactgtcc acgtgggcat tcacccaagc      360

aaggtggtta tcaccaggct aaaactggac aaggatcgga aaaaaattct tgaacgcaaa      420

gccaagtctc gacaagttgg aaaagagaaa ggcaaatata aagaagaact tattgagaaa      480

atgcaggaat aaatagaacc tgttgtgcaa ccacggttta accggagatt ttgaggctag      540

ggtgtgtttc tttcgaactt ttcggaatgt ctggaacatt tcatttcctg ttttgttacc      600

tgtgcctctg taaatctact tttgcaattt taagtaataa ttttatgaat aaaaatggga      660

aatgcttcct aattccacat agtatttgca ttgttttata aataaattcc acttactatc      720

aa                                                                     722


<210> 452
<211> 5905
<212> DNA
<213> Homo sapiens

<400> 452
gctgcactgg gtgtcaagcg ccacggggtt tgatggggac tccttctggt tccaccctcg       60

cccactcact tctcgggctg gccataatgc tgcacagagc cccggccagc cattaatatc      120

aggcgcagga gaaaacccag taaaatcact taccagtctt ccacctccgg tgctgatcta      180

gcaagagcct gacccgctgg ccagactcaa gctctgcacc aggtattacc accctggcga      240

cggctccgga gcgtcactga caaccacccg gaaatggtac tatcgcttcc ggggctgcct      300

agcgcgcggc gggaaattgt ttcccagagc ccggattcgt gaagcagttg agtgctgcag      360

cggcagtcgt cgcccctgcc gccgctgcca ccgaaggaag catcccagac accgggaaga      420

tggaagatgg taccccaaag catatcatcc agatgacagg atttaagatg gaagaaaaag      480

aagcgctagt caaattactt ttaaaactag attgcacttt tattaagagt gagaaataca      540

aaaattgtac acatcttata gctgaacgcc tatgtaagag tgaaaaattt ttagcagctt      600

gtgcggcagg aaagtggata ctaaccaagg actatataat tcatagtgcc aaaagtggca      660

gatggcttga tgaaacaact tatgaatggg gatataaaat tgaaaaagat tcccgttatt      720

cacctcaaat gcaatctgca cctaaaagat ggcgtgaaga actgaaacgc actggtgctc      780

caggagcctt ccacagatgg aaagttgtcc tccttgttag aactgataag cgaagtgatt      840

ctcttataag agttttggag gctggaaagg caaatgttat tttaccaaaa agttcaccaa      900

gtggaataac tcatgtgatt gccagtaatg caagaattaa agctgagaaa gaaaaagata      960

actttaaggc tccattttat ccaattcagt atctagggga ttttctttta gagaaagaaa     1020

ttcagaatga tgaagattcc caaaccaatt ctgtttggac tgaacatagc aatgaagaaa     1080

caaacaaaga tttcaggaaa gatgcaggat ttcttgaaat gaaaggtgcc ttaagagaga     1140

ccatgtatag aacccagaaa gaaatgcaaa atcatgaaga tgttaatgtt ggttctattt     1200

tgattcaaca tcacaaaaaa gaaaaattca gtggttccag taaagatttg aaatttgtta     1260

aaatgagaaa tacctttgga agccatacat atgaaaatca gaaggaaatt aagaaaaaag     1320

atgaagatat tcagaggagt tatactttga ggagaaaacg caagaaagga aaagaaagca     1380

attgcaagaa aggcgttgaa catgaaaaaa taaaaagtac cttaagaagg cacatatata     1440

atagagatca gaaagaaatg aagaattcta tttttgctga atatgccaaa gaatcaaaag     1500

ccatggctat taagacagat gtggatgttg ttgaaataaa aaatacctta aggaagcaca     1560

tatatagagc tcaggctgtc agatacaact gcattagaat agataaacaa ccagtgtaca     1620

acgtagaggt taaaaatgct gaatttccca gaggtgtatt aaatttaatt gaaagcctca     1680

tagaaggaca tttttttaaa gaagcaattg aggaactttc cactttgcag gcacattata     1740

tccctcctgt atgcgttctt catgcccttc tagagaacgt tctacaggat aacatagata     1800

cattttctgg tcgatacttt catatattgt cagctcttct tcacctgcat cctccttgga     1860

agtctccagc catgtcgaga tattatttag agttgtttca gtgtccaact tgtatgaaag     1920

gagcatggtc tttagtagaa gtccttatca ggtcttgcct tttcaatgaa agcttttgtc     1980

atcaaatttc agaaaatatt ggctccaagg tgctccacct gacgctactc aaatttttct     2040

ttaatttaat tgaaagtgaa gtacaacatc tgagtcaaaa gttgtatgac tggtcagatt     2100

ctcagaatct gaaaataaca ggaaaggcaa tgcttcttga aattttttgg tcaggaagtg     2160

aaacctctgg gcttttgacc aaaccagtaa atatgctttt ggaatggact atatattctc     2220

acaaggaaaa attcaagtct aatgatgtct tcaaacatga actagcttac ttattggctg     2280

gaattcttgg agcagcaata gattattgga ttttccttgg tcttaagatg ggtagaaatg     2340

tgatgcgaca catgtctgat gacttaggaa gttatgtttc tctttcgtgt gatgactttt     2400

cttcacagga attagagatt ttcatttgct ccttttcctc ctcctggctt caaatgtttg     2460

ttgcagaggc agtctttaaa aagttgtgtc tacagagctc tggcagtgtt tcttctgagc     2520

cactctctct tcagaaaatg gtatattcct atttaccagc cttggggaaa actggtgtgc     2580

ttgggtctgg aaagattcag gtgtcaaaga aaataggaca gcggccttgt tttgactctc     2640

agagaacctt actaatgctg aatggtacta aacaaaaaca agtcgaaggg ctgccagagt     2700

tactagacct gaaccttgct aaatgttcct catcattaaa aaaattgaaa aagaagtcag     2760

aaggagaatt gtcatgttcc aaggagaatt gcccctctgt agttaaaaag atgaattttc     2820

acaagactaa tctaaaagga gaaacagccc tgcatagagc ttgcataaat aaccaagtgg     2880

agaaattgat tcttcttctc tctttgccag gaatagacat caatgttaaa gacaatgctg     2940

gctggacgcc tttgcatgaa gcctgtaact atggcaacac agtgtgtgtc caggaaattt     3000

tgcaacgttg tccagaggta gatctgctca ctcaagtgga cggggtgact cctttgcatg     3060

atgcactgtc aaacggacat gtagaaattg gcaagctgct actacagcat gggggcccag     3120

tgcttttaca acagaggaat gctaagggag aattgccctt ggattatgtg gtttcacctc     3180

aaatcaaaga agaactgttt gctattacaa aaatagaaga tacagtggag aactttcatg     3240

cacaagcaga gaaacatttt cattaccagc aacttgaatt tggctccttt ttacttagta     3300

ggatgttgct aaatttttgt tcaatttttg atttatcttc agagttcatt ttagcttcca     3360

aagggttaac tcatctaaat gaactgctta tggcttgtaa aagtcataaa gaaaccacca     3420

gtgttcatac tgactggtta ctggatcttt atgctggaaa tataaagaca ttgcagaaac     3480

tcccacacat tcttaaggaa ctgcctgaga atttgaaagt gtgtcctggg gtacacactg     3540

aggccttgat gataacattg gaaatgatgt gtcggtcagt catggagttt tcatgatgat     3600

gctagaaagt atggattgac tttctaaatc tgttcagttt gcattggtac ttactgtgga     3660

cttcatagct tactgacaga tagtaatttg atttatttat tgacagactt tgcagccttg     3720

ctaaatttta aaagcatttt taaaaaaact tctacaaaac tctagtatgg gcttctgact     3780

ttttccaggg tgtagaattt gactcaaaag taaaaataat tttgttttag tatattctac     3840

tttcattaat gtttttttgt tctgaaagtg atattatatt gtacatgtaa aattaattta     3900

aatatttttt caaataaaaa tgtaatgtcc tgtattctag atgttctagg tcttagaatc     3960

atggcaagca tattcataca aatgcgtacc tataaacttg tagctcctga ctcttaggga     4020

tggattttga ggaaaaaaca agactaaaca aaaacatgta gctccctatt tcttctctct     4080

aggttgttgg actgaaatat gcattttagc tttgtgtgtt tctaaaataa acatttctaa     4140

aatttacagt aataattaat attcttttgg tttttaaatg cagcaaatat gcagagtctg     4200

acagttcaat tccttgatct gttttatttt agcaattcat atacaaaatg tatctgtcgc     4260

tgccctatgt aacccagtat tctgtacctg aaaacattct gctgcatagg tttatgagtt     4320

taatattaag atattgagtg gcatctaagt aatagatttg agattattta agatcttaat     4380

atatagtatg aatttactga gtagtaatgt tttaatttgc agtttttcct tatagcagtt     4440

tgtagtaaaa ctaaaagaaa gggtgtggat aataaccact tttgagattg gagtttcttc     4500

actactggga gtaagttaca ttatgataca ggtggaaaat aaacacttcc atttagcttt     4560

tatgtaattc aagtgatgac cttagcagtt aatctgctaa agcaatacac ttcagtttta     4620

ttttggaaat agatatttta acaagataca aatgctcagt atcatattac tgggtttgta     4680

atctaaattg aaaactgcta tatcagtatg aaaaaatatt ttaaataagt actttttcca     4740

cacatactca ggaaatacta gtttctattt agccttcaaa tttggcatca tacaaatctc     4800

tttattatta atctgccaaa gtatcagaca aaaaatgata tagtgaagac tatctaagaa     4860

gagtttaaat gcttatagag agtaaagtgc ttctccagat gatgaataag aacgtttttt     4920

attccaatga gtacctcttt acttcacttg taaaggtgtc tgggatagtg tttgcttggt     4980

aaactaatat aaacttgtaa acataggctt tgacatcata cacattttca aatccttgtc     5040

tagtttctta ataactaaat tgcaaggcaa attcttttct gagctttggc tttcctacat     5100

gtcaaataga aatcacacca ggtatctttg tcatgataga attgttagca tatcacatca     5160

tatgacactt aataaatatt atttcctttc taattcttac ctcctctttt gattataatg     5220

aatcatttag acaaaaggca atatagtaat tgtttaagtt ggtagtaatt ctaaggtaat     5280

taaggaatca acatcatgag ttagggtttt atactgttag tacaaagtag ttttccaaat     5340

tagatgttca taacgtatat ttgtttaatt gcaattagca ttaatatttc ataattgact     5400

gctctgtctg ccaacttcta caagcagtga tgacatgaag tgtgaaacag atgtcactga     5460

ggtctctgcc tttaagaagt tttacacttc ttcgaaagtc caacgtggca aacataggtt     5520

actgtgttct gtgccctggc taacaatacc agtatatgag tatgaatcta aatgttcagg     5580

aaaaggcttc attcccaaaa ttacttctta tactttattt tagaaaacat aataataatt     5640

gccttgaata attgcccaaa tctatcttgg aggtatagga agaagaaatt ctcaataagt     5700

aaagtataat tcatagtctt agtcctagat tttcaatggc agacttttca aagttgcatc     5760

tgaagacaag gttgagaaat gctattcttc actgtatttt gccagatgtg atatcatagt     5820

tctatggaat catatttttt aaatttctgt aagagacctt attacaatgt aaataaagct     5880

ggagaggaga tttctgagca gttaa                                           5905


<210> 453
<211> 1437
<212> DNA
<213> Homo sapiens

<400> 453
agtcacagcc aggtaaccct ggagtgaagc ggtttagtta gaagggagca gataaactcg       60

tcactctagt agctttaacc ctcaccctga ggcaccttag caatcagcca ttgcctgcaa      120

gcctccaaag cttgtctttg cctaatatgg agcccaaaga agccactggg aaagaaaaca      180

tggtcaccaa gaaaaagaat ctggccttct tgaggtctag actctatatg ctggagagaa      240

ggaagactga cactgtggtt gagagcagtg tttctgggga ccactctggc accttgagga      300

ggagccaatc tgacaggact gaatacaacc agaaattaca agaaaagatg actccacagg      360

gtgagtgttc tgtagctgag accttaaccc cagaggaaga gcatcatatg aagaggatga      420

tggcaaagcg ggaaaagatc attaaggagc tgatacagac agaaaaggat tatctcaatg      480

atctagagct gtgtgttagg gaagtggttc agcccctgag aaataaaaag actgataggc      540

tggatgtgga tagcttgttt agcaacattg agtccgtgca tcagatatca gccaagctgc      600

tgtcattgtt ggaagaggcc acaacagacg tggaaccggc catgcaagta attggagaag      660

tattcttgca gattaaaggg ccactggaag atatttataa aatctactgc tatcaccatg      720

atgaagcaca tagtatactg gagtcctatg aaaaggaaga agagctgaag gaacatttga      780

gccactgtat ccagtcctta aagtaaggcc ttttcaaatg atgattccca tctcctctca      840

gttgcctagc agggaacatt ttaaatggat gtagatgaaa ggtctcacat aaatcctatg      900

ttttatgaga cttgctggga gctctgcttt gcattccctt tataaaaagc tgacatgcca      960

gaagccctga ttgacttttt ttccccctgc gagaatgact aaaaataaca tggaagaaga     1020

tttagagctc tgcagcgatt gaaaaatgca atatcaaaat ataaaatgtg gaagaaaagc     1080

ctcttcttaa agctattgta acttgcctgg ccccacgtag ttcaaggatt atgtgagata     1140

acacgtggcc ccatgaccac tggagcacat gggttaatgg agttagggga atggcctaca     1200

actctgcatg gccgtcttct ttccccaaac tcactgtggg gagatgggtg aagacaagtc     1260

aggccttgtt aaagttagtt tcagaacaat tactcatgcc ttcctttctc atccctaaaa     1320

cattggtggg ggagctacac aatgtacttt ttcttttcta gaggaagtat ctattcactg     1380

tgaaaatctg aaaaatataa caaagtatgt gtaagataaa aaccccttgc tatttca        1437


<210> 454
<211> 6451
<212> DNA
<213> Homo sapiens

<400> 454
gggttagttc ctgttaggcc ccggccgggg gagtaggttg aagtctccta agatgcccgg       60

tgggctgggg caccgggagc tgtgaaggga acgtgagggg gcggcgtagt ggagacccac      120

ggcaggcctg aagaagagcg gcggccgagc ccgccttccc tgcaccatgc tcatagagga      180

tgtggatgcc ctcaagtcct ggctggccaa gttactggag ccgatatgtg atgctgatcc      240

ttcagcctta gccaactatg ttgtagcact ggtcaagaag gacaaacctg agaaagaatt      300

aaaagccttt tgtgctgatc aacttgatgt ctttttacaa aaagaaactt caggttttgt      360

ggacaaacta tttgaaagtc tctatactaa gaactacctt ccacttttgg aaccagtaaa      420

gcctgagcca aaaccactag tccaagaaaa agaagaaatt aaagaagagg tatttcagga      480

gccagcagag gaagaacgag atggcagaaa aaagaaatat cctagtcccc agaagactcg      540

ttcagaatct agtgaacgaa ggacacgtga gaaaaaaaga gaagacggga aatggagaga      600

ctatgaccgg tactatgagc ggaatgaatt gtaccgtgag aagtatgact ggagaagagg      660

caggagtaag agtcggagta agagtcgagg cctgagtcgc agtagaagcc gaagtagggg      720

gcgcagcaaa gaccgggatc caaataggaa tgttgagcac agggaaagat cgaagtttaa      780

gagtgaaagg aatgacctgg agagttccta tgtgcctgtg tctgcaccac ctccaaactc      840

ttctgagcag tattcctctg gggcacagtc tattcccagc actgttactg tgatcgcacc      900

tgctcaccac tctgaaaaca caactgagag ttggtctaat tactataaca atcatagctc      960

ttccaattct tttggtcgaa acctaccacc aaagaggcga tgcagagatt atgatgaaag     1020

aggattttgt gtacttggtg acctttgtca gtttgatcat ggaaatgatc ccctagttgt     1080

tgatgaagtt gctctgccaa gtatgattcc tttcccaccc cctcctcctg ggcttcctcc     1140

tccaccacct cctggaatgt taatgcctcc aatgccaggt ccaggcccag gcccgggccc     1200

aggtccaggc ccaggcccgg gcccaggtcc aggtcctggc catagtatga gacttcctgt     1260

tccccaagga catggtcagc ctccaccatc cgttgtgctt cccataccaa gaccacctat     1320

aacacaatca agcttgataa acagccgtga ccagcctggg acaagtgcag tgcccaatct     1380

tgcatcagtg ggaacaagac tacctcctcc tttaccccag aacctccttt acacagtatc     1440

agaacgacag cccatgtact ctcgtgaaca tggtgctgct gcatctgagc gacttcagtt     1500

ggggacaccg cctcctctgt tggcagctcg tttggtgcca cctcgaaacc tcatgggatc     1560

ctccattgga taccatacct cagtctccag ccctacccct ctggttccag atacatatga     1620

accagatggt tacaacccag aagctcctag tattactagt tctggtagat ctcagtacag     1680

acagttcttt tcaagaactc agacacagcg tcccaatctg attggcctaa catctggaga     1740

tatggatgta aatccaagag ctgctaacat tgtgatccag actgaaccac cagttcctgt     1800

ttcgattaat agcaacataa ccagagtagt tcttgaacca gatagtcgaa aaagagctat     1860

gagtggtttg gaagggccac tcacaaagaa accttggctg ggaaagcaag gaaataacaa     1920

tcaaaataaa ccagggttct tacgaaagaa tcagtataca aacaccaaat tagaagtcaa     1980

gaaaatccct caggaattga acaacattac caagctcaat gaacacttca gcaaatttgg     2040

aactattgtt aatatccagg ttgcttttaa gggtgaccca gaagcagccc taatccaata     2100

tcttaccaat gaggaggcca ggaaagccat ttctagcaca gaagcagttc taaacaaccg     2160

attcattcga gtcttgtggc atagggaaaa taatgagcaa ccgacactac agtcctcagc     2220

acagctgctc ctgcaacaac agcaaacact tagtcacctc tcacagcagc accatcacct     2280

gccacagcat ctacatcagc agcaggtgct agtggcccag tctgctcctt caacagtgca     2340

cggaggtatc cagaagatga tgagcaaacc acagacatca ggtgcatatg ttcttaacaa     2400

agttcctgtt aaacatcgtc ttggacatgc aggtggtaac cagagtgatg catcacattt     2460

gttgaatcag tctggtggtg ctggagaaga ttgccagata ttttcaactc caggccatcc     2520

aaaaatgatt tacagctcct caaacttaaa gacaccttca aagctctgtt cagggtctaa     2580

atctcatgat gttcaagaag tgcttaaaaa aaaacaggaa gcaatgaagt tacaacaaga     2640

tatgaggaaa aaaagacagg aagtgttaga aaagcaaata gaatgccaaa agatgttaat     2700

atccaagtta gaaaaaaaca aaaacatgaa accagaagaa agagcaaata taatgaagac     2760

tttgaaagag cttggagaga agatctcaca attaaaagat gaattaaaaa catcttctgc     2820

agtctccaca ccatctaaag tgaagacaaa aacggaggcc cagaaggagt tattagatac     2880

tgaactggac ctccacaaga ggctgtcctc aggagaagac accacagaat tacggaaaaa     2940

actcagtcag ttacaggttg aggctgcacg gttaggtatt ttacctgtgg gtcgaggaaa     3000

gaccatgtcc tctcaaggtc gaggaagagg ccgagggcgt ggaggaagag gaaggggctc     3060

actaaatcac atggtggtgg accatcgtcc caaagcacta acagttggag gattcattga     3120

ggaagaaaaa gaagacttgc ttcagcattt ctcaaccgca aaccaagggc caaaatttaa     3180

agaccgtcgg ctacagatat catggcacaa gcccaaggta ccatctatat ccactgagac     3240

tgaagaagaa gaagtcaagg aggaggaaac agaaacctca gatttgtttt tgcctgatga     3300

tgacgatgaa gatgaagatg aatatgagtc tcgctcatgg cgaagatgaa atctgatgct     3360

agctgtataa tttttaggaa tattgtttag aagaacaact tttaaaaatt atttaaaaga     3420

agtcaatgag ccaaaaaaaa tttttttatt tttcttttca acacagtagg ttcaagaaca     3480

gcaagtttgc tatttaaaca catctcataa ctgtacatga tattaaagca ccaaaggcct     3540

agtgactttt acacagttgt gaagatccac agcaatgaca tggataatct ctagagcctt     3600

attttccaca ccaccttttt tttgttgctg ttggtgttgg attatgatgt aaatgacagg     3660

gtgttcagaa attttatttt ggattataat ctactgataa aatttaatta aatgtcaaaa     3720

tcacctgtaa tcttttaact ctcagttgtt atggatgggt catcagacag taggaaatat     3780

ttgtaattaa aatacccttt tgctttcaag agtggtcttg gaagaaaaat atgtttattt     3840

taattttaat tttttttttt ttttactttg gaggagccca atttgtattc agtctaaatt     3900

tgtttttcat ggtttttatg tgtggtagta ctagttcagt gaaaatcaca acaaactgtg     3960

tgttcttaaa tgctacagca atggtagcta gctctatagt atttccattc tcttgtcata     4020

tgaactcctg gacttttcct gctactgatt cttagtttgc tttgatattt agtgagcgct     4080

ggttcggctg gtctttttaa aaatttttat aactcagaat gtaaaaggct ttcacctatt     4140

gcccctttct cgtccccctt ttcttcctct tgcctttcta ttaataggcc tgacttagtc     4200

atcattgata taagtggttc atttgggcaa ccgcaggcag tctccaataa aaggttcaaa     4260

ccagcacctg gataaataag tgatgttttg atgagaatga tggaaggatt ttggggagaa     4320

gagaatcacc agctttattt tttccctctt ttgaagcttc agttcagtat agttacacag     4380

aagggtttaa aaatgtctga aattcttttc ctaaatttaa accatgatgg tgaggtgact     4440

ggggggtggg gggtggaggt gggagggggt tgagggctga gtatgctagt aataaatggg     4500

agtcatatat gactttgttc agatgacctt attttttcat aattttgtag cttgttgcta     4560

tccatgaaca tacgcatccc tcagtagaca gtttccttta ctgtgtgcat ttttactgta     4620

cactgtatag agtagagtat ctgttaagta aaatatatat gtaaatttat gtcttcgtgt     4680

tctgaatgtt agatggaaaa gcagaggagc aacactacac tgtactgacc cctgggaaaa     4740

taaaatgatt aatgtaccta ggctgtcact ttttcaagga tatacacatc tgtgttttta     4800

tatatgtgtg gtatgaaaat ttgaaacctc ctgttgtctc caaaagggtc ttggtgacca     4860

ctatatcaag gattttgttt gctgaggtaa agacaatttc tcaatataga aactattcac     4920

taagaactta aaaccatcag gattctagat ttacttagct ataagaagtt aaatcccacg     4980

ttctgataat ctttattctt ctacatgttt tcctggaatg atgtgtcaaa ccagggtcat     5040

ttttaagttc atataatttt ctttcataat aatgaggact tcctttttct aggttattgt     5100

tatatttcta gtaacactga aggtaaaata agcttataaa agaaggaaaa catcagaatg     5160

gtgtatctag aatacacaat cttgctcctt actcctccat catctctaat gaaatttttc     5220

ttgatgtctg tggctcagtc agtatatatt ttgaaagatt cattgtggtg aatattttga     5280

gtcctgacag tttaaacgtg atagagggaa caaaggattt atatattttt tgtacaaagt     5340

tttttcttaa actgtataat tttgtaaata atttgtttgg gttttttttt tgtgtactaa     5400

aactaccagc gtatagattt caataagaat tgttgtattt ttgtatttgg aaactgaaaa     5460

ttacagtaaa taaatggaac tctaagaaaa atttcagtag acagttcaac agaatgagat     5520

tccttttcat atgatttttt tgacctcaaa atggacatct tatttcactc tcagtaaaaa     5580

gttgaaaatt tgacttttta gtattggggg cagaagatag aagtgtgtta aagtgaaaaa     5640

cagttttttc agtaaggttt gaggcccttt ctataagttt tcagtacacc ttaaacagga     5700

ctaaaaatac tttaaaagtg tgctttcaaa gaattttaaa acatgtttga ctcaaagatg     5760

aatttgaagt gagttaatta taatactgga aaacttcagg ttagcataaa atagtttata     5820

tatatcccct gccccctttg ggatttactt ccaccatcaa atcttcaact gttagaattt     5880

cacttaaaag tgaataactg ccatacatgt tttcttggca tcttcattta cagaaataac     5940

atacagcatc taaagcaagt tctgtccctc ttaatgtgta tgacatcttt ttaagtagct     6000

gatcagcaat aatagccacc agttgactag gtcagcctga tatactagtg gatcactgtc     6060

caagataaaa aggtaacccc aagtattgca aaatttccct caatttcttt atgtaacatt     6120

gaagaaatgt tgttaccagc taagatgata aattggaaaa cagtcttgtt aaggtgaaag     6180

gggtccttgg tgatggatca ttatttcaaa aaagaaaaaa atcatgtgaa aaggaatagt     6240

ggttcctctt gatgtatagt atgcctgtat tatagttttt acaaaattgt gaacttgtgt     6300

aatagtataa taggagatat tgttgaattt ctaactgttt atacatttaa attcatatat     6360

gtaatgtttg ttttatcaat tacaatctga atttctaaga agcatgttga cttttgcaat     6420

aaagatgcaa tatggaatgg ttcacaattg g                                    6451


<210> 455
<211> 2668
<212> DNA
<213> Homo sapiens

<400> 455
acatgcgcag tagctgtagg agggggtggg cgctccattg ggcgtttctc ttggtttttc       60

ctttccgcgc ggcttgggcg gacgtctcgt gagacgtggg acttctcgcg ggaactgcat      120

tcaaatatcc caggcgctta ctcgagagct agctgagcga atgggccggc gactgtggag      180

ttagcgtcct caatgtggac gccctgagct cccattagga gccgctggct gcggcagcag      240

gggactagcg tgagagttgg ctaaaaaaaa gaaaagaaca tggaggcaga tataatcaca      300

aatcttcgat gcaggctcaa agaggctgaa gaagagcgac taaaagctgc acagtatggt      360

ttacaactag tagagagtca aaatgaatta cagaatcaat tggataaatg tcgtaatgaa      420

atgatgacca tgactgagag ttatgaacaa gaaaaatata cccttcaaag agaagttgaa      480

ctcaagagtc gaatgttaga aagtttgagc tgcgaatgtg aagctattaa acaacaacaa      540

aaaatgcacc tggagaaatt ggaagaacaa ctaagcagaa gccatggaca ggaagtgaat      600

gaactaaaaa ctaagataga aaaactgaaa gtggaattag atgaagccag gcttagtgaa      660

aagcagctga agcaccaagt agatcatcag aaggaactcc tctcttgtaa atcagaggaa      720

ctgcgcgtaa tgtctgaacg tgtgcaggaa agcatgtctt cagagatgct ggctcttcaa      780

attgagctga cagaaatgga gagtatgaag accaccctca aagaagaagt gaatgaacta      840

caatacagac aagaacagct agaacttctt attactaacc taatgcgcca ggtagaccgg      900

cttaaagagg aaaaagagga gcgagagaaa gaagcagttt cttactataa tgccctagag      960

aaagctcgtg tagcaaatca agatcttcag gtacagttgg accaggcact ccagcaagcc     1020

ttggatccca atagtaaagg caactctttg tttgcagagg tggaagatcg aagggcagca     1080

atggaacgtc agctcatcag tatgaaagtc aagtatcagt cactaaagaa gcaaaatgta     1140

tttaacagag aacagatgca gagaatgaag ttacaaattg ccacgttgct acagatgaaa     1200

gggtctcaaa ctgaatttga gcagcaggaa cggttgcttg ccatgttgga gcagaagaat     1260

ggtgaaataa aacatctttt aggtgaaatt agaaatctgg agaaatttaa gaatttatat     1320

gacagtatgg aatctaagcc ttcagtcgac tctggtactc tggaagataa cacctattat     1380

acagatttac ttcagatgaa gctggataac ttaaacaaag aaattgaaag cactaaaggt     1440

gaattgtcca tacagcgaat gaaagcatta tttgagagcc agcgggctct agatattgag     1500

cgaaaacttt ttgcaaatga aagatgcctc cagctttcag aaagtgaaaa tatgaaactg     1560

agagctaaac tagatgaatt gaaactaaaa tatgaacctg aagagacagt tgaagtgcct     1620

gtactgaaaa agaggcgtga ggtgctccct gtggatataa ccaccgctaa agatgcatgt     1680

gtcaacaaca gtgctctcgg gggagaagtt tatcgattac cgcctcagaa agaggagaca     1740

cagtcctgcc ctaacagttt agaagataac aacttgcaat tagaaaaatc agtttctata     1800

tacacaccag tagtcagtct ctctcctcac aaaaatctgc ccgtggatat gcagctgaag     1860

aaggaaaaga aatgtgtgaa actcatagga gttcccgctg acgctgaggc cttaagtgaa     1920

agaagtggaa acacccctaa ctctcccagg ttagctgctg aatcaaagct tcaaacagaa     1980

gttaaagaag gaaaagaaac ttcaagcaaa ttggaaaaag aaacttgtaa gaaattacac     2040

cctattctat atgtgtcttc taaatctact ccagagaccc agtgccctca acagtaaaga     2100

cttgtcttta ataagagtac ggtgccactt gcctcaaaag ttactatggt gcttaagatt     2160

gtcttgatct gacatatatc accttctggg ttatttactc attgtgccag gacctggcat     2220

tttcatgtgc ctttgaccaa gtgttcagaa tttgcttgac tctaacctgg agagcttctt     2280

aagtgatgcc ccttcatgga gcttctatga cagtgaataa actattaatt gaaggaaaat     2340

gttataatta atgtatctat ttgctgcatt gtatatggat taaatgataa aaaacaagta     2400

atctaccctc agagccatgt atttgagaat gcttcaatca tattttccta tgtacttttt     2460

tttataaact tagttttaga ctatgttgta aaaatgggaa ggttgtaaac tatgttgtaa     2520

aaataggaaa tgtggcttaa aatatataca ttatattgtt tcaggatttt gtcagtgttt     2580

aaagaaccaa tgttcatctt tgtatttata tacatgattt aaattttgtc taaaatttta     2640

aataaaactg cagtgattta tccttaaa                                        2668


<210> 456
<211> 1511
<212> DNA
<213> Homo sapiens

<400> 456
aacagttgcc ttttcctctc acagaaggaa gatttcattt tgtttgagac gagaaaccaa       60

accacacacc aaagagaggg gtatgatggc taagaagccc ccaaaaccag cccctcgcag      120

gatcttccag gaaaggttaa agattactgc tctacctttg tactttgaag gttttttatt      180

aatcaagcgg tcaggatacc gggagtatga gcattactgg acagagttga gaggaactac      240

tcttttcttt tataccgaca aaaagagtat aatatatgtt gacaaattag acatagtaga      300

cctcacatgc cttactgagc agaattcaac tgaaaagaac tgtgcgaaat tcacccttgt      360

tttgccgaaa gaggaagtac aactgaagac agagaacaca gaaagtgggg aagaatggag      420

aggcttcatt cttacagtaa cagagctgtc agttccccaa aacgtgtcac tcctacctgg      480

gcaagtaatt aaactgcatg aagtcctaga gagagaaaag aaaaggagga ttgagacaga      540

gcagagtacg tccgtggaaa aagagaagga accaactgaa gattatgtgg atgtactgaa      600

ccctatgcca gcatgttttt atacagtgtc ccggaaagag gcaactgaga tgctccagaa      660

gaacccttct ttgggaaata tgatcctgag gcctggtagt gacagtagaa actactccat      720

cactattcgg caggagatag acattccaag aatcaagcac tacaaagtga tgagcgtagg      780

acaaaactac actattgaac tggaaaaacc tgtaacactc ccaaaccttt tcagtgtcat      840

tgattatttt gtgaaggaga ctcgaggaaa tttaagacca tttatatgtt caactgatga      900

aaacactggt caagaaccca gtatggaagg gagaagtgaa aagttgaaga aaaatccaca      960

cattgcatga aatacaatgt gaaagctcct ttgtatatct tggtaattta tattttcaaa     1020

acgaagttct tacttttaaa gagaattacc tatattctcc tgatactgat taccaagtca     1080

ttcacctgaa caccagaatt agaattaaac attgtaccat acaatttcat tatcttatca     1140

gaatgaaacc aattcacagg gaaactagag actacggctg tggtggtaac ctgcagatat     1200

acacattccc atgcactgac ataagttgaa aacacatagt actttctaga tggaattttt     1260

ttctttaggc ctcaatgaaa tacatttccc ctatataatt ccaacagcag tttctctagt     1320

tctaaatttt accaattccc aaaaaaccta agttttgctg aaatctgatt tgaccaattt     1380

atcaaatatg tcattttaat tacctagctg gaagttagag acatgaaatg tactagagga     1440

gcccttttcc aatggaaata ttatatacca cattttttgt taatggaaat aaatgtcttc     1500

attcccatgt t                                                          1511


<210> 457
<211> 6234
<212> DNA
<213> Homo sapiens

<400> 457
atgtttcata tctgcccagc agagaatctg taccagaaca ggtttttagg cctggccgcc       60

atggcgtctc cttctagaaa ctcccagagc cgacgccggt gcaaggagcc gctccgatac      120

agctacaacc ccgaccagtt ccacaacatg gacctcaggg gcggccccca cgatggcgtc      180

accattcccc gctccaccag cgacactgac ctggtcacct cggacagccg ctccacgctc      240

atggtcagca gctcctacta ttccatcggg cactctcagg acctggtcat ccactgggac      300

ataaaggagg aagtggacgc tggggactgg attggcatgt acctcattga tgaggtcttg      360

tccgaaaact ttctggacta taaaaaccgt ggagtcaatg gttctcatcg gggccagatc      420

atctggaaga tcgatgccag ctcgtacttt gtggaacctg aaactaagat ctgcttcaaa      480

tactaccatg gagtgagtgg ggccctgcga gcaaccaccc ccagtgtcac ggtcaaaaac      540

tcggcagctc ctatttttaa aagcattggt gctgatgaga ccgtccaagg acaaggaagt      600

cggaggctga tcagcttctc tctctcagat ttccaagcca tggggttgaa gaaagggatg      660

tttttcaacc cagaccctta tctgaagatt tccattcagc ctgggaaaca cagcatcttc      720

cccgccctcc ctcaccatgg acaggagagg agatccaaga tcataggcaa caccgtgaac      780

cccatctggc aggccgagca attcagtttt gtgtccttgc ccactgacgt gctggaaatt      840

gaggtgaagg acaagtttgc caagagccgc cccatcatca agcgcttctt gggaaagctg      900

tcgatgcccg ttcaaagact cctggagaga cacgccatag gggatagggt ggtcagctac      960

acacttggcc gcaggcttcc aacagatcat gtgagtggac agctgcaatt ccgatttgag     1020

atcacttcct ccatccaccc agcagatgat gaggagattt ccctgagtac cgagcctgag     1080

tcagcccaaa ttcaggacag ccccatgaac aacctgatgg aaagcggcag tggggaacct     1140

cggtctgagg caccagagtc ctctgagagc tggaagccag agcagctggg tgagggcagt     1200

gtccccgatg gtccagggaa ccaaagcata gagctttcca gaccagctga ggaagcagca     1260

gtcatcacgg aggcaggaga ccagggcatg gtctctgtgg gacctgaagg ggctggggag     1320

ctcctggccc aggtgcaaaa ggacatccag cctgccccca gtgcagaaga gctggccgag     1380

cagctggacc tgggtgagga ggcatcagca ctgctgctgg aagacggtga agccccagcc     1440

agcaccaagg aggagccctt ggaggaggaa gcaacgaccc agagccgggc tggaagggaa     1500

gaagaggaga aggagcagga ggaggaggga gatgtgtcta ccctggagca gggagagggc     1560

aggctgcagc tgcgggcctc ggtgaagaga aaaagcaggc cctgctcctt gcctgtgtcc     1620

gagctggaga cggtgatcgc gtcagcctgc ggggaccccg agaccccgcg gacacactac     1680

atccgcatcc acaccctgct gcacagcatg ccctccgccc agggcggcag cgcggcagag     1740

gaggaggacg gcgcggagga ggagtccacc ctcaaggact cctcggagaa ggatgggctc     1800

agcgaggtgg acacggtggc cgctgacccg tctgccctgg aagaggacag agaagagccc     1860

gagggggcta ctccaggcac ggcgcaccct ggccactccg ggggccactt ccccagcctg     1920

gccaatggcg cggcccagga tggcgacacg caccccagca ccgggagcga gagcgactcc     1980

agccccaggc aaggcgggga ccacagttgc gagggctgtg acgcgtcctg ctgcagcccc     2040

tcgtgctaca gctcctcgtg ctacagcacg tcctgctaca gcagctcgtg ctacagcgcc     2100

tcgtgctaca gcccctcctg ctacaacggc aacaggttcg ccagccacac gcgcttctcc     2160

tccgtggaca gcgccaagat ctccgagagc acggtcttct cctcgcaaga cgacgaggag     2220

gaggagaaca gcgcgttcga gtcggtaccc gactccatgc agagccctga gctggacccg     2280

gagtccacga acggcgctgg gccgtggcaa gacgagctgg ccgcccctag cgggcacgtg     2340

gaaagaagcc cggaaggtct ggaatccccc gtggcaggtc caagcaatcg gagagaaggt     2400

gaatgtccta tactccataa ttcccagcca gtaagccagc ttccttccct gaggcctgaa     2460

catcatcact acccaacaat cgatgagcct cttccaccaa actgggaagc tcgaattgac     2520

agccacgggc gggtctttta tgtggaccac gtgaaccgca caaccacctg gcagcgtccg     2580

acggcagcag ccaccccgga tggcatgcgg agatcggggt ccatccagca gatggagcaa     2640

ctcaacaggc ggtatcaaaa cattcagcga accattgcaa cagagaggtc cgaagaagat     2700

tctggcagcc aaagctgcga gcaagcccca gcaggaggag gcggaggtgg agggagtgac     2760

tcagaagccg aatcttccca gtccagctta gatctaagga gagaagggtc actttctcca     2820

gtgaactcac aaaaaatcac cttgctgctg cagtccccag cggtcaagtt catcaccaac     2880

cccgagttct tcactgtgct acatgccaat tatagtgcct accgagtctt caccagtagc     2940

acctgcttaa agcacatgat tctgaaagtc cgacgggatg ctcgcaattt tgaacgctac     3000

cagcacaacc gggacttggt gaatttcatc aacatgttcg cagacactcg gctggaactg     3060

ccccggggct gggagatcaa aacggaccag cagggaaagt cttttttcgt ggaccacaac     3120

agtcgagcta ccactttcat tgacccccga atccctcttc agaacggtcg tcttcccaat     3180

catctaactc accgacagca cctccagagg ctccgaagtt acagcgctgg agaggcctca     3240

gaagtttcta gaaacagagg agcctcttta ctggccaggc caggacacag cttagtagct     3300

gctattcgaa gccaacatca acatgagtca ttgccactgg catataatga caagattgtg     3360

gcatttcttc gccagccaaa catttttgaa atgctgcaag agcgtcagcc aagcttagca     3420

agaaaccaca cactcaggga gaaaatccat tacattcgga ctgagggtaa tcacgggctt     3480

gagaagttgt cctgtgatgc ggatctggtc attttgctga gtctctttga agaagagatt     3540

atgtcctacg tccccctgca ggctgccttc caccctgggt atagcttctc tccccgatgt     3600

tcaccctgtt cttcacctca gaactcccca ggtttacaga gagccagtgc aagagcccct     3660

tccccctacc gaagagactt tgaggccaag ctccgcaatt tctacagaaa actggaagcc     3720

aaaggatttg gtcagggtcc ggggaaaatt aagctcatta ttcgccggga tcatttgttg     3780

gagggaacct tcaatcaggt gatggcctat tcgcggaaag agctccagcg aaacaagctc     3840

tacgtcacct ttgttggaga ggagggcctg gactacagtg gcccctcgcg ggagttcttc     3900

ttccttctgt ctcaggagct cttcaaccct tactatggac tctttgagta ctcggcaaat     3960

gatacttaca cggtgcagat cagccccatg tccgcatttg tagaaaacca tcttgagtgg     4020

ttcaggttta gcggtcgcat cctgggtctg gctctgatcc atcagtacct tcttgacgct     4080

ttcttcacga ggcccttcta caaggcactc ctgagactgc cctgtgattt gagtgacctg     4140

gaatatttgg atgaggaatt ccaccagagt ttgcagtgga tgaaggacaa caacatcaca     4200

gacatcttag acctcacttt cactgttaat gaagaggttt ttggacaggt cacggaaagg     4260

gagttgaagt ctggaggagc caacacacag gtgacggaga aaaacaagaa ggagtacatc     4320

gagcgcatgg tgaagtggcg ggtggagcgc ggcgtggtac agcagaccga ggcgctggtg     4380

cgcggcttct acgaggttgt agactcgagg ctggtgtccg tgtttgatgc cagggagctg     4440

gagctggtga tagctggcac cgcggaaatc gacctaaatg actggcggaa taacactgag     4500

taccggggag gttaccacga tgggcatctt gtgatccgct ggttctgggc tgcggtggag     4560

cgcttcaata atgagcagag gctgagatta ctgcagtttg tcacgggaac atccagcgtg     4620

ccctacgaag gcttcgcagc cctccgtggg agcaatgggc ttcggcgctt ctgcatagag     4680

aaatggggga aaattacttc tctccccagg gcacacacat gcttcaaccg actggatctt     4740

ccaccgtatc cctcgtactc catgttgtat gaaaagctgt taacagcagt agaggaaacc     4800

agcacctttg gacttgagtg aggacatgga acctcgcctg acattttcct ggccagtgac     4860

atcacccttc ctgggatgat ccccttttcc ctttccctta atcaactctc ctttgatttt     4920

ggtattccat gatttttatt ttcaaaccaa atcaggattg acaaaagctg tgcatgaaga     4980

actgccttct tctaagatct aaccttcagg cttctctcct ctgttttcaa tgaactgcta     5040

gcctgtatgc aatattaaaa aacagctgtc tcaaggtctg tgtatatctc cacatacctc     5100

cattactaac aatgaaatat gaatgcaagt taagctacac ttgaccaaat ggtaataaat     5160

gtttacttcc atttctatca ttgaagggaa aatgtgagca ttaagcactc caggctttca     5220

tatgcccatg tcttctgagc agagccacca ttttttataa tttctaataa ccaactccag     5280

aactaggagc tgatcaactc tttgttttcc tctccatcta cttttccctg tgcataatat     5340

ccatccaaag gacaacagtg gcaaagctga aatttttata cattcaactc atgattcaca     5400

tgtggcatca gtcccatcag ccggaactag cctagacata cggtgcaaat atgacacttc     5460

taacgattaa caacagcaag aaaacacctg ctgctgatgc aatgcaatgc atcccaatgg     5520

ttgtggggat tgtgggctca actcaagaga agtttaggag ggggagcatc cctagtgaat     5580

actcacacca caagaaggac aaacttgtgc acatgtccaa gaaagaaagc ttcttgattg     5640

aggtagcatg aaggatgagg cttcagcccc cattgtctta tgtagaatgt ggcaatgcca     5700

actggagaaa gggaagaagg acatattacc ttggtttgaa tccctgagtt ctgtactgtt     5760

ctgttttgtt tagtctagcc acagttcttc acaaaggaaa aaaaaatgtg tagatgatac     5820

catgactttt gttaaagcca tgacttttgt ttgcttggca gacaaaccct ttttttaaaa     5880

ctttgatatt tttttttcac attttttttt ccttttcctt tcttaatcat ggagttcaag     5940

ttcctttgca ttcgattgtc catcgggacc acactaggaa gctgcagaga gtgatggtgc     6000

ttgttaggga tcaagggcaa catagtactt ctccttcacc catagtaatc ctcctggggc     6060

agaaacataa caccccaaag gcacgttgat ttgtatcaaa ataaatatcc agtttctttt     6120

agcattcagt gaaaacatat ctcagaaaac ttcatgttgt cagaaaaaca gctgcaggct     6180

ccaaagacag cctaacctct caactacatt tgaaataaac ccaaccataa tggt           6234


<210> 458
<211> 3311
<212> DNA
<213> Homo sapiens

<400> 458
gtggtgccca tcagcatgtg gagccggcca ccgcccctgc ctccatagaa gcccgctgcc       60

gcccagtccg cggtaccttg agggtcacgt cgcacagctt gccctgccgc cggatctcct      120

ccatgacgcc gtagccgcga ctaggcaact cagacacgga gaagtgcacc agatcctcca      180

gctcctccgc gccgtcctcc accatcttcc ccggccgctg caactgcgca ggcctcgccg      240

gccggctaga cactaaccag ggcggggcga tagcgcacgc cgacagccgc tcggagcgcg      300

gagcagcaat cggacgggcc tccgcggccg ccgtagttga atctcctcgg cgccggaagc      360

cccgccactc cgcttcctgg ttcatgtgcg gccttcgttc cctcgctatc tcgaccttga      420

cttcgcatgt gcatccgccg aagtctttct agatcaatcg gccccatctc tcgtcttccc      480

gattcggcca tgacctcacc cgtatcctcg acgtaggacc tcggacttca tttccgccac      540

cccgacactt ccggaatccc cggaagcgac ccgttgccat ggcgactatg tacacagcca      600

ggcagccccg cgtggggagt gcaggtggtt tcggttgcgg cagtcgcgtc ccgggagcgt      660

cgctgcctgg tgaacgctag aatgggtact aggaaaaaag ttcatgcatt tgtccgtgtc      720

aaacccaccg atgactttgc tcatgaaatg atcagatacg gagatgacaa aagaagcatt      780

gatattcact taaaaaaaga cattcggaga ggagttgtca ataaccaaca gacagactgg      840

tcgtttaagt tggatggagt tcttcacgat gcctcccagg acttggttta tgagacagtt      900

gcaaaggatg tggtttctca ggccctcgat ggctataatg gcaccatcat gtgttatggg      960

cagacgggag ctggcaagac atacaccatg atgggggcaa ctgagaatta caagcaccgg     1020

gggatcctcc ctcgtgccct gcagcaggtt tttaggatga tcgaagaacg ccccacacat     1080

gccatcactg tgcgtgtttc ctacttggaa atctataatg agagcctgtt tgatctcctg     1140

tccactctgc cctatgttgg accctcagtc acaccaatga ccatcgtgga aaaccctcaa     1200

ggagtcttca ttaagggctt gtcagttcac ctcacaagtc aggaggagga tgcattcagc     1260

ctcctttttg agggtgagac caacaggatt atagcctccc acactatgaa caaaaactct     1320

tccagatcac actgcatttt caccatctac ttagaggccc attcccggac cttatcagag     1380

gaaaagtaca tcacttccaa aattaacttg gtggatctgg caggctcaga gaggctgggg     1440

aagtctgggt ctgagggcca agtcctgaag gaagccacct acatcaacaa atcgctctca     1500

ttcctggagc aggccatcat tgcccttggg gaccagaagc gggaccacat cccctttcgg     1560

cagtgcaagc tcacccacgc tctgaaggac tcgttagggg gaaactgcaa tatggtcctc     1620

gtgacaaaca tctatggaga agctgcccag ttagaagaaa cgctatcttc actgagattt     1680

gccagcagga tgaagctagt caccactgag cctgccatca atgaaaagta tgatgctgag     1740

agaatggtca agaacctgga gaaggaacta gcactactca agcaggagct ggctatccat     1800

gacagcctga ccaaccgcac ctttgtgacc tatgacccca tggatgaaat ccagattgct     1860

gagatcaact cccaggtgcg gaggtacctg gaggggacac tggacgagat cgacataatc     1920

agccttagac agatcaagga ggtgttcaac cagttccggg tggttctgag ccaacaggaa     1980

caggaagtgg agtccacttt gcgcaggaag tacaccctca ttgacaggaa tgactttgca     2040

gccatttctg ctatccagaa ggcggggctt gtggatgttg atggccacct agtgggtgag     2100

cctgaaggac aaaactttgg actcggagtc gcccctttct ctaccaaacc tgggaagaaa     2160

gccaagtcca agaagacatt caaagagcca ctcagctcct tggcaagaaa ggaaggtgcc     2220

agcagccctg tgaatgggaa ggacttggat tacgtttcca cctccaagac ccagctggtc     2280

ccatcctcca aagatgggga tgtcaaagac atgctttcgc gggaccggga aacttccagc     2340

attgagcccc ttccctcaga ctccccgaag gaggaattac gcccaattag gcccgacacc     2400

ccaccctcca aaccagtggc ctttgaggag tttaagaatg agcaaggtag tgagatcaac     2460

cgaattttca aagaaaacaa atccatcttg aatgaacgga ggaaaagggc cagcgagacc     2520

acacagcaca tcaatgccat caagcgggag attgatgtga ccaaggaggc cctgaatttc     2580

cagaagtcac tacgggagaa gcaaggcaag tacgaaaaca aggggctgat gatcatcgat     2640

gaggaagaat tcctgctgat cctcaagctc aaagacctca agaagcagta ccgcagcgag     2700

taccaggacc tgcgtgacct cagggctgag atccagtatt gccagcacct agtggatcag     2760

tgtcgccacc gcctgctcat ggaatttgac atctggtaca atgagtcctt tgtcatccct     2820

gaggacatgc agatggcact gaagccaggc ggcagcatcc ggccaggcat ggtccctgtg     2880

aacaggattg tgtctctggg agaagatgac caggacaaat tcagccagct gcagcagagg     2940

gtgcttcctg agggccctga ttccatctcc ttctacaatg ccaaagtcaa gatagagcag     3000

aagcataatt acttgaaaac catgatgggc ctccagcagg cacatagaaa atagaacctc     3060

atcgccagta ccttaaagga caagaccagc aactcccacc tactgtagtg gagctgctca     3120

accacctgcc cagagctgca gccccctcta ctccaatgct gggacccagc acagagaaca     3180

catttggcct gcatgttggg aggagcatcc tccaaggaca accttgctca tctccacaga     3240

gcactttggg ttttaattca ctgtcttata tgcagggaca ggataaaata actttctagt     3300

ttggactttc a                                                          3311


<210> 459
<211> 1055
<212> DNA
<213> Homo sapiens

<400> 459
gaggggacgc gcgcagatga cgtgcggctc gtggggcagc tcggcagcat ggcgtccgtg       60

acgctgagcg aggcggagaa ggtgtacatc gtgcatggcg tccaggaaga cctccgtgtg      120

gatggccgtg gctgtgagga ctaccgatgt gtcgaagtgg aaactgatgt ggtgtccaac      180

actagtgggt ccgccagggt caagctgggt cacacagaca tcttggtggg agtgaaagca      240

gaaatgggga cgccgaagct ggagaaacca aatgaaggct acttggagtt ctttgttgac      300

tgttcagcca gtgctacccc tgaatttgaa ggtagaggag gtgatgacct tggcaccgag      360

atcgctaaca ccctctatcg gatatttaac aataaaagca gtgtcgactt aaagaccctc      420

tgcattagtc ctcgggagca ctgctgggtt ctctatgtgg atgtgctgct tctggaatgt      480

ggtggaaatt tgtttgatgc catttccatt gctgtaaagg ctgctctctt caatacaagg      540

ataccaaggg ttcgagtttt ggaggatgaa gaggggtcga aggacattga attgtcagat      600

gacccttatg actgcatacg actaagtgtg gagaatgtcc cctgcattgt cactctgtgc      660

aagattggct atcggcatgt ggtggatgct actcttcagg aggaggcctg ctcgctggcc      720

agcttgctgg tgtcggtgac cagcaaggga gttgtgacgt gcatgaggaa agtggggaag      780

ggcagcctgg acccagagag catcttcgag atgatggaga ctggcaagcg tgtgggcaag      840

gtactgcatg cctccttgca gagtgttgtg cacaaggaag aaagcctggg gcccaagaga      900

cagaaagttg gattcctggg atgatttgca catcaactgc tcaactgtgg attgtttttt      960

acttttcctt ttaaaccggt tcgtatatat ttttcttcgc tgttacgaat ttacagcagc     1020

atttgtacat gtaaaattaa aggctatttt ctggt                                1055


<210> 460
<211> 4794
<212> DNA
<213> Homo sapiens

<400> 460
cgtgggcacc tccagataag aaaacaagct cagagagatg tggtgacttg ctcaaatagt       60

gacagaactt cctcggccat atggaggggt catataatac ccttgtgtct tcagtttgag      120

gagagcttgt ttcatatcca tatcccactg tattcctgct aatctgctaa tgcagtaaat      180

tggaggaaaa ctgttaccag gataacctgt aatgggcaag gagccacaaa gaagaaaaca      240

tttcttttaa tttttaaact tggtttgaaa gaccagcatg ttttggaaat ttgatcttca      300

ctcatcatcc cacatagaca cacttctaga aagagaagat gtaacactga aggagttaat      360

ggatgaggaa gatgttttac aggaatgtaa agctcagaac cgcaaactta tagagtttct      420

gttaaaagca gaatgtctcg aagatttagt ctcattcatt atagaagaac cacctcaaga      480

catggatgaa aagatcagat acaagtatcc aaatatatct tgtgagttgc tcacttctga      540

tgtctcccag atgaatgata gactgggaga agatgaatcc ttgctaatga aattatatag      600

cttcctccta aacgattccc ctttgaatcc actacttgcc agtttcttca gcaaggtgct      660

aagtattctt atcagcagaa aaccagaaca gattgtggat ttcttaaaga agaagcatga      720

ttttgtagac cttattataa agcacatagg aacttctgct atcatggatt tgttgctcag      780

gctcctgacg tgtatcgaac ctccacagcc caggcaagat gtgctgaatt ggttaaatga      840

ggagaaaatt atccagaggc ttgtggaaat agttcatcca tcgcaagaag aagatcgaca      900

ttcaaatgca tcacaatcac tttgtgaaat tgttcgcctg agcagagacc agatgttaca      960

aattcagaac agtacagagc ccgaccccct gcttgccact ctagaaaagc aagaaattat     1020

agagcagctt ctatcaaata ttttccacaa ggagaaaaat gagtcagcca tagtcagtgc     1080

aatccagata ttgctgactt tacttgagac acgacgacca acatttgaag gccatataga     1140

gatctgccca ccaggcatga gccattcagc ttgttcagta aacaagagtg ttctagaagc     1200

catcagagga agacttggat cttttcatga actcctgctg gagccaccca agaacatgtt     1260

cttcaagtat acatggaata actttttgca tacacaagtg gaaatttgta ttgcactgat     1320

tcttgcaagt ccttttgaaa acacagaaaa tgccacaatt accgatcaag actccactgg     1380

tgataatttg ttattaaaac atcttttcca aaaatgtcaa ttaatagaac gaatacttga     1440

agcctgggaa atgaatgaga agaaacaggc tgagggagga agacggcatg gttacatggg     1500

acacctaacg aggatagcta actgtatcgt gcacagcact gacaagggcc ccaacagtgc     1560

attagtgcag cagcttatca aagatcttcc cgacgaagtc agggaacgat gggagacgtt     1620

ctgcacaagc tccttaggag aaactaacaa gaggaacacg gtagatctag ccttttctga     1680

ttatcagatg caacaaatga cgtccaattt tattgaccag tttggcttca acgatgagaa     1740

gtttgcagat caagatgaca ttggcaatgt ttcttttgat cgagtatcag acatcaactt     1800

tactctcaat acaaatgaaa gtggaaatat tgccttgttt gaagcatgtt gtaaggaaag     1860

aatacaacag tttgatgatg gtggctctga tgaggaagat atatgggagg aaaagcacat     1920

cgcattcaca ccagaatccc aaagacgatc cagctcgggg agtacagaca gtgaggaaag     1980

tacagactct gaagaagaag atggagcaaa gcaagacttg tttgaaccca gcagtgccaa     2040

cacggaggat aaaatggagg tggacctgag tgaaccaccc aactggtcag ctaactttga     2100

tgtcccaatg gaaacaaccc acggtgctcc attggattct gtgggatctg atgtctggag     2160

cacagaggag ccgatgccaa ctaaagagac gggctgggct tctttttcag agttcacgtc     2220

ttccctgagc acaaaagatt ctttaaggag taattctcca gtggaaatgg aaaccagcac     2280

tgaacccatg gaccctctga ctcccagtgc ggctgccctg gcagtgcagc cagaagcggc     2340

aggcagtgtg gccatggaag ccagctctga cggagaggag gatgcagaaa gtacagacaa     2400

ggtaactgag acagtgatga atggcggcat gaaggaaacg ctcagcctca ctgtagatgc     2460

caagacagag actgcggtct tcaaaagtga ggaagggaaa ctgtctacct ctcaagatgc     2520

tgcttgtaaa gacgcagagg agtgtcccga gactgcagag gcgaagtgcg cggcgcccag     2580

gcctcccagc agcagtcccg agcagaggac tggccaacca agcgcaccag gtgacacttc     2640

agtgaatggc cctgtatgac gggtgacgtc tgctgctgct gactgaggac tgcagaccgc     2700

caccactcag gggctctgga ggggtcagct ggagcccacc aagctgtcac tgctgcactc     2760

actctgcaag ggatcaggac cagcaacctt tatattctag attctaagac attgtacaga     2820

gaaattcaga agtgtaaaaa tattgcacat tgacaaatac caagaatttt tgcgtatgtt     2880

tatattgtat tgttctaaat aatgggtagc ctgtgaaata agatcttgcc acccatgtaa     2940

taatagtagt aatactatag ttaaaatggc tgtaagaata gttttataaa agtgaataca     3000

cagatctatt gtatttgaaa cataactttg acaattatta gtgtgaccaa agtattaggc     3060

ggttttcata catttttcac cttgtacaaa attatgaatt catttttcct ccaggccgac     3120

aaggagttgt agaatgaaaa tgccctctaa gtgttatttt ggttgttcta acttacaaaa     3180

gtgattttga ataagaaata tttggtgttc tttttataac cagtttttga ttggtaattg     3240

ttttctgtat tgtttaaaac ggatcaaaaa tgtaagtcta ttggtagaga ttaagtaaag     3300

tatttattgc tacatcatag ttgataaatt gatgttatcg taaagccata tgttctgttc     3360

aagtcttgtt tgcttgaaat gattattcct acaagtgaaa cactagacta tttggagtgt     3420

atatggcttg tgttttggga tttttttttt ttttttttgg cttttgtttt tgtttgtttt     3480

tttgtttcat ttggtagttc atctgccttt taacccattc accaaaattt accttgttaa     3540

caagcatcac caatgaacat ttcagagcaa tctgcatatt taacagacct aaaataaatc     3600

ctattaggca agtcagttga aaatgctcgt gctgctaatg gaattagagt gcgttcattt     3660

tacaggctag tattttaaaa gtagaaatca aaatctggca ccgaagcatg ctaattgttt     3720

actgtacctt gtgaggtttt cactcataaa tttaaaccag tgtatttttt tagaactggt     3780

ttgtgtatat atatagtgat tatggatact aattcaatgt aatttataat tttctatgtc     3840

aatacaaaaa tacatcacag ccttctcaaa cagctcaagc aatatattgt atattgccat     3900

atcgtctggt gaaagggtta aattacttca cctcttgcac ttttagatgc aaatcagttt     3960

ttcatttctg taatagaaaa ttattcacgt atttttacat catttgtttt tcctgaccag     4020

tatttaaaac caaaaggata ttctgaaaaa tggccaacaa tttttttaga agtagcatcc     4080

caagcagcgt gcctaaacat tacattgcat atggaaataa aagaatcaaa cgtctaatgc     4140

cttattattt ctgatttcct ttttcatttt aagtggtgtg gagattccag cactcccagg     4200

acagtggagt cagcagtaag ccctgggaca ggtggcaagg gtgggtccct tgacctttgc     4260

acgcctcctc aggaaccccc tttcccgggt gagcccctct ctgaagagac tgtccttggg     4320

cctcctctgg aagcagcacc cccagaggac agggctcctc ctgcttgcct cagggctgcc     4380

tgacttgaat ggcgttggac ctcggggatt actggtagat aatatgctct ggtctcgcct     4440

ggtggtgagt tttgccagcc atggccaggg tttggctcca ctggtggcac acgtggcctc     4500

cgtggtatgg acctggtggc ttctccatcc cactgtggcc tctgtggtat ggacctggtg     4560

gcttctccat cctacccaag gtaacagtgt cttgcttcat cccactgact gctgggagag     4620

agcctctggg acttttcttt ggggcatcat tttgttttgt ctttcgtagc agggaaagga     4680

tatgacaatg gggaggacag ttcttttgga ggttggaggg gccaagccaa ggacaggagc     4740

aagtgtgccc tcattttgtt tctactttta atttctgtgt gttggccata ctga           4794


<210> 461
<211> 4787
<212> DNA
<213> Homo sapiens

<400> 461
agcgcgcatg ctcgcggctc ggcgctgaaa ttcaaatttg aacggctgca gaggccgagt       60

ccgtcactgg aagccgagag gagaggacag ctggttgtgg gagagttccc ccgcctcaga      120

ctcctggttt tttccaggag acacactgag ctgagactca cttttctctt cctgaatttg      180

aaccaccgtt tccatcgtct cgtagtccga cgcctggggc gatggatccg tttacggaga      240

aactgctgga gcgaacccgt gccaggcgag agaatcttca gagaaaaatg gctgagaggc      300

ccacagcagc tccaaggtct atgactcatg ctaagcgagc tagacagcca ctttcagaag      360

caagtaacca gcagcccctc tctggtggtg aagagaaatc ttgtacaaaa ccatcgccat      420

caaaaaaacg ctgttctgac aacactgaag tagaagtttc taacttggaa aataaacaac      480

cagttgagtc gacatctgca aaatcttgtt ctccaagtcc tgtgtctcct caggtgcagc      540

cacaagcagc agataccatc agtgattctg ttgctgtccc ggcatcactg ctgggcatga      600

ggagagggct gaactcaaga ttggaagcaa ctgcagcctc ctcagttaaa acacgtatgc      660

aaaaacttgc agagcaacgg cgccgttggg ataatgatga tatgacagat gacattcctg      720

aaagctcact cttctcacca atgccatcag aggaaaaggc tgcttcccct cccagacctc      780

tgctttcaaa tgcctcggca actccagttg gcagaagggg ccgtctggcc aatcttgctg      840

caactatttg ctcctgggaa gatgatgtaa atcactcatt tgcaaaacaa aacagtgtac      900

aagaacagcc tggtaccgct tgtttatcca aattttcctc tgcaagtgga gcatctgcta      960

ggatcaatag cagcagtgtt aagcaggaag ctacattctg ttcccaaagg gatggcgatg     1020

cctctttgaa taaagcccta tcctcaagtg ctgatgatgc gtctttggtt aatgcctcaa     1080

tttccagctc tgtgaaagct acttctccag tgaaatctac tacatctatc actgatgcta     1140

aaagttgtga gggacaaaat cctgagctac ttccaaaaac tcctattagt cctctgaaaa     1200

cgggggtatc gaaaccaatt gtgaagtcaa ctttatccca gacagttcca tccaagggag     1260

aattaagtag agaaatttgt ctgcaatctc aatctaaaga caaatctacg acaccaggag     1320

gaacaggaat taagcctttc ctggaacgct ttggagagcg ttgtcaagaa catagcaaag     1380

aaagtccagc tcgtagcaca ccccacagaa cccccattat tactccaaat acaaaggcca     1440

tccaagaaag attattcaag caagacacat cttcatctac tacccattta gcacaacagc     1500

tcaagcagga acgtcaaaaa gaactagcat gtcttcgtgg ccgatttgac aagggcaata     1560

tatggagtgc agaaaaaggc ggaaactcaa aaagcaaaca actagaaacc aaacaggaaa     1620

ctcactgtca gagcactccc ctcaaaaaac accaaggtgt ttcaaaaact cagtcacttc     1680

cagtaacaga aaaggtgacc gaaaaccaga taccagccaa aaattctagt acagaaccta     1740

aaggtttcac tgaatgcgaa atgacgaaat ctagcccttt gaaaataaca ttgtttttag     1800

aagaggacaa atccttaaaa gtaacatcag acccaaaggt tgagcagaaa attgaagtga     1860

tacgtgaaat tgagatgagt gtggatgatg atgatatcaa tagttcgaaa gtaattaatg     1920

acctcttcag tgatgtccta gaggaaggtg aactagatat ggagaagagc caagaggaga     1980

tggatcaagc attagcagaa agcagcgaag aacaggaaga tgcactgaat atctcctcaa     2040

tgtctttact tgcaccattg gcacaaacag ttggtgtggt aagtccagag agtttagtgt     2100

ccacacctag actggaattg aaagacacca gcagaagtga tgaaagtcca aaaccaggaa     2160

aattccaaag aactcgtgtc cctcgagctg aatctggtga tagccttggt tctgaagatc     2220

gtgatcttct ttacagcatt gatgcatata gatctcaaag attcaaagaa acagaacgtc     2280

catcaataaa gcaggtgatt gttcggaagg aagatgttac ttcaaaactg gatgaaaaaa     2340

ataatgcctt tccttgtcaa gttaatatca aacagaaaat gcaggaactc aataacgaaa     2400

taaatatgca acagacagtg atctatcaag ctagccaggc tcttaactgc tgtgttgatg     2460

aagaacatgg aaaagggtcc ctagaagaag ctgaagcaga aagacttctt ctaattgcaa     2520

ctgggaagag aacacttttg attgatgaat tgaataaatt gaagaacgaa ggacctcaga     2580

ggaagaataa ggctagtccc caaagtgaat ttatgccatc caaaggatca gttactttgt     2640

cagaaatccg cttgcctcta aaagcagatt ttgtctgcag tacggttcag aaaccagatg     2700

cagcaaatta ctattactta attatactaa aagcaggagc tgaaaatatg gtagccacac     2760

cattagcaag tacttcaaac tctcttaacg gtgatgctct gacattcact actacattta     2820

ctctgcaaga tgtatccaat gactttgaaa taaatattga agtttacagc ttggtgcaaa     2880

agaaagatcc ctcaggcctt gataagaaga aaaaaacatc caagtccaag gctattactc     2940

caaagcgact cctcacatct ataaccacaa aaagcaacat tcattcttca gtcatggcca     3000

gtccaggagg tcttagtgct gtgcgaacca gcaacttcgc ccttgttgga tcttacacat     3060

tatcattgtc ttcagtagga aatactaagt ttgttctgga caaggtcccc tttttatctt     3120

ctttggaagg tcatatttat ttaaaaataa aatgtcaagt gaattccagt gttgaagaaa     3180

gaggttttct aaccatattt gaagatgtta gtggttttgg tgcctggcat cgaagatggt     3240

gtgttctttc tggaaactgt atatcttatt ggacttatcc agatgatgag aaacgcaaga     3300

atcccatagg aaggataaat ctggctaatt gtaccagtcg tcagatagaa ccagccaaca     3360

gagaattttg tgcaagacgc aacacttttg aattaattac tgtccgacca caaagagaag     3420

atgaccgaga gactcttgtc agccaatgca gggacacact ctgtgttacc aagaactggc     3480

tgtctgcaga tactaaagaa gagcgggatc tctggatgca aaaactcaat caagttcttg     3540

ttgatattcg cctctggcaa cctgatgctt gctacaaacc tattggaaag ccttaaaccg     3600

ggaaatttcc atgctatcta gaggtttttg atgtcatctt aagaaacaca cttaagagca     3660

tcagatttac tgattgcatt ttatgcttta agtacgaaag ggtttgtgcc aatattcact     3720

acgtattatg cagtatttat atcttttgta tgtaaaactt taactgattt ctgtcattca     3780

tcaatgagta gaagtaaata cattatagtt gattttgcta aatcttaatt taaaagcctc     3840

attttcctag aaatctaatt attcagttat tcatgacaat atttttttaa aagtaagaaa     3900

ttctgagttg tcttcttgga gctgtaggtc ttgaagcagc aacgtctttc aggggttgga     3960

gacagaaacc cattctccaa tctcagtagt tttttcgaaa ggctgtgatc atttattgat     4020

cgtgatatga cttgttacta gggtactgaa aaaaatgtct aaggccttta cagaaacatt     4080

tttagtaatg aggatgagaa ctttttcaaa tagcaaatat atattggctt aaagcatgag     4140

gctgtcttca gaaaagtgat gtggacatag gaggcaatgt gtgagacttg ggggttcaat     4200

attttatata gaagagttaa taagcacatg gtttacattt actcagctac tatatatgca     4260

gtgtggtgca cattttcaca gaattctggc ttcattaaga tcattatttt tgctgcgtag     4320

cttacagact tagcatatta gttttttcta ctcctacaag tgtaaattga aaaatcttta     4380

tattaaaaaa gtaaactgtt atgaagctgc tatgtactaa taatactttg cttgccaaag     4440

tgtttgggtt ttgttgttgt ttgtttgttt gtttgttttt ggttcatgaa caacagtgtc     4500

tagaaaccca ttttgaaagt ggaaaattat taagtcacct atcaccttta aacgcctttt     4560

tttaaaatta taaaatattg taaagcaggg tctcaacttt taaatacact ttgaacttct     4620

tctctgaatt attaaagttc tttatgacct catttataaa cactaaattc tgtcacctcc     4680

tgtcatttta ttttttattc attcaaatgt attttttctt gtgcatatta taaaaatata     4740

ttttatgagc tcttactcaa ataaatacct gtaaatgtct aaaggaa                   4787


<210> 462
<211> 3352
<212> DNA
<213> Homo sapiens

<400> 462
agtcaccccg gcatgtgggc gcggcggggc ggcgcgggcg ggacggctac aagagctgtt       60

ttgcgtccgg gccggagtat ttgctcagcc cgcctgcgcc gcttgggacg cctctgcctt      120

tccctccctc ccttccccga cggcttctgg cggccaagtg gatgtggcgg gtgatcgagc      180

caccctgccc aggggcgccc agcactggtt cagtgaacag cattttggac aggacatttg      240

gtgccaggtc tgagtagcca gtttgctgaa ttattgtccc agtcagccag gattgtgagc      300

tgtttgggaa gtttcgtgga aacgcccaag tgccagcaca ggtggaggga cacctggagg      360

ccagtttcag gaacttttgc cacaagtata aaagacttca gaagtgcaaa gatgctgaaa      420

cagatactgt cggagatgta catagatcct gatctactgg cagagctcag cgaagaacag      480

aaacagatcc tgttcttcaa gatgagagag gaacagatcc gacgatggaa agaaagagaa      540

gcagctatgg aaagaaagga gtccctgcca gtgaaaccca gaccaaagaa agagaatggc      600

aaatcggttc attggaaact tggagctgat aaggaagtct gggtatgggt gatgggcgaa      660

caccatctag ataaacccta tgatgtgctc tgtaatgaaa ttattgctga gagggcccgg      720

ctgaaagcag aacaggaggc agaagagccc agaaaaactc actctgaaga attcaccaat      780

agcttgaaaa caaaatcaca gtaccatgat ctgcaggctc cggataacca gcagactaaa      840

gacatctgga agaaagtggc agaaaaggag gaactggagc aaggatcgag gccagcacca      900

accctggaag aagagaaaat ccgatcactc tccagttctt caagaaatat tcaacaaatg      960

ttggcagatt caatcaatcg tatgaaggca tatgcatttc accagaagaa agaatctatg     1020

aagaaaaaac aagatgaaga aataaatcaa atagaagaag agagaacgaa gcagatttgt     1080

aagagctgga aagaagactc ggaatggcag gcatctctgc gaaaatccaa agcagctgat     1140

gagaagagac gctccttggc taaacaagca cgagaagact acaagaggtt atccctcggg     1200

gcccagaaag gaagaggcgg tgagaggctg caaagcccct tgcgtgttcc gcagaaacca     1260

gaaagacctc cccttccacc caagcctcag ttcctaaact caggggcata tcctcaaaaa     1320

cctcttagaa atcagggagt ggtgaggaca ctgtccagct ctgcccaaga ggacatcatc     1380

cggtggttta aagaggagca gctaccactt cgagcgggct accagaaaac ctcagacacc     1440

atagccccct ggttccatgg aattctcaca ctcaagaaag caaatgaact tcttctgagc     1500

acaggcatgc ccggcagttt tctcatccga gtcagtgaaa ggatcaaagg ctatgccctg     1560

tcctatctgt cggaggacgg ctgtaaacat ttcctcatcg atgcctctgc agacgcctac     1620

agcttcctgg gcgtggacca gctacagcat gccaccttgg cggatttggt ggaatatcac     1680

aaggaggaac ccatcacttc cctggggaag gagctccttc tctatccctg tggtcagcag     1740

gaccagctgc ctgactacct ggagctgttt gagtgacagc ctccatcagg gtcatcctac     1800

agcctccaag cgggctttcc cctggacaaa tgccactgca acatttatgt gtgaagccaa     1860

aatcaccctg cagcagagcc aatactgatc aactgaaagt aaagtatcca tggagtcctc     1920

attgacacct cttttctgca caaatactgg aattcaatgt caagagaaaa tgacctctgc     1980

tcaaaaggga gaagagtctc aatttcagca agtacctgtc atgaagggta tgaccttaat     2040

gatgtacata aaataaaaca aatgaagaaa tggaaaactt ttagaaatta aggtgtactt     2100

gaaaacgaat atctatcata tgacccctgc actccctctg tatcatctca ggaggtttca     2160

ggggcctgtt gacatgaagt ttcgaagttt catgttggct ttggaatggt agcaaaagcc     2220

tttcctggct gagatgatgc ttaaaacaca cctcacttat tgtacatgtt ggaaccagga     2280

catgagagac atagaaaaac agaagtcatg aatgtaaatt gaatgagagg cttaacatgc     2340

atgaaaatac agatggacct gcaggaaagt gagcaaacat cgctgagttt gttttcttgt     2400

tcgggagaat ggggccgggg ctggcctggc ctcccctgga tatactctat agtgcaccaa     2460

aaggataaag catctgtaca tgtatttttt tattttttat cagaagtgct tagacaagaa     2520

cagaataagc aggctgtttg gatgctactt gtggttgaat tgtgttcccc caaaatatat     2580

ggtgaagtct taacccccat ccccgtgaat gggaccttgt ttggaaatag ggtctttgca     2640

gatatagtca agatgaggtc acattggatt agggtgggcc ccaaatccaa tgactggcat     2700

ccttaggaga agagagagtt ttggtaatag acacaaatgc agtgggaaga agaccagggg     2760

acaagaggca agttggagtg atgcagccgg aagggaaggg acaccaagga tctccggcca     2820

ccagcagaag ccagcagaga ggcatgggac aggttcccca caagccttag aaggaagcat     2880

ggccctgact tcagaattcc agactccaga actggaagaa taaatgtctg ttgttttaag     2940

ctgcttagtt catgctgagt tcatgctgac ttgttactat agccccagaa agctaataca     3000

gtcgtttatg taattacata acctgacaca caagatcgac ccattcactg ctgcccagtc     3060

caccattttc ataatgaagt agaaatggga ggtaagaaaa acattccagc cagttctgtt     3120

tagccctggc acacatattt gtcccgtcag gaatcttatg ccctcctgga acccccgccc     3180

acctcagtcc agtcccagtc aggcgaacgg cctctggaca gggactgagg tggctctgag     3240

ccactggaga tcatttttct tggaggatgg agattggcta gtacctctgg cctaactgtg     3300

taggtcaata ctcttttaca ttgccttcta ataaaagcag aatgatacag ca             3352


<210> 463
<211> 2238
<212> DNA
<213> Homo sapiens

<400> 463
ccctttcccc actgtggtgt gataagaggc tgccctcaca gtcacaatgc tcccgggtca       60

cagaggtgct gggccccagg ccagcctctg cctgggaagt tctctctggg aacatctggt      120

gggtactaca ggccctattc caggccctat ggcctgtgga acctcaccac gggggggagg      180

gctgggccag acggagacat cacctgtggt gtcagcccca tggatgagac agagtggata      240

cacagacatc ccaaggctga ggacctaagg gttgggctca tcagctgggc aggaacctac      300

ctcacctttg aggcatgcaa gaatacagtc actgcaactg cgaagagttt gggcaggaga      360

cagacctggg agatcttggt gagcaatgag catgagacac aggccgtggt gcgactaaag      420

agcgtgcagg gcctctacct gctgtgtgag tgtgatggca ccgtgtgtta tggccgccca      480

aggaccagcc accatgggtg ctttctactg cgtttccacc ggaacagcaa gtggaccctc      540

cagtgcctaa tctctggtcg ttatttggag tccaatggca aggacgtgtt ttgcacttcc      600

cacgtcctct cagcttacca catgtggacc ccccgaccag ccctccatgt ccacgtgatc      660

ctctacagcc ccatccaccg ctgctatgcc cgggctgacc ccactatggg ccgcatctgg      720

gtggacgcag cagttccctg cctggaggag tgtggcttcc tgttgcattt ccgagatgga      780

tgctaccacc tggagacctc tacacaccac ttcttgtccc atgtagaccg gctgttctcc      840

caaccctcat cacagacagc ttttcacatg caagtgcggc ctggagggct tgtggcactg      900

tgtgatggag aaggaggcat gttatatcca cagggcacgc atctgctctt gggcatgggc      960

tgcaacccca tgaggggtga ggagtggttc atcctacagc actgcccaac ctgggtcagc     1020

ctcaggtcaa agactgggcg gttcatctca gtcatctacg atggtgaggt gcgtgctgct     1080

tctgagcgct taaaccgaat gtccttgttc cagtttgaat gtgacagtga gagccccact     1140

gtgcagcttc gttcagccaa tggctactac ctatcccaga ggcgccacag ggcagtaatg     1200

gctgatgggc accccctgga gtctgacacg ttcttccgaa tgcactggaa ctgtggcagg     1260

atcatcctgc agtcctgcag ggggcgcttc ctgggcattg cacccaacag cctgctgatg     1320

gccaatgtca tccttccagg cccaaatgag gaatttggga ttttatttgc caatcgctcc     1380

ttccttgtat tgcgaggtcg ttatggctat gtgggctcct catcgggcca tgacctcata     1440

cagtgcaacc aggatcagcc cgaccgcatt catctactac cctgccgacc gggtatctac     1500

cacttccagg cacagggggg atccttctgg tcaataacat cctttggcac ctttcgccct     1560

tggggcaagt ttgccctcaa cttctgtatc gagcttcagg ggagcaactt actcactgta     1620

ctggccccca atggcttcta catgcgagcc gaccaaagtg gcaccctgtt ggcagacagt     1680

gaagacatta ccagagagtg tatctgggaa ttttaggtca atgggatgtc acctaccaaa     1740

atccaaatcc tccaggaaaa actactacac taaatggacc aggaacctca gagtcaagat     1800

ccaagagaag aacatctgtt acaacttttc ctacccagtt tagcaaaaca cctgttttat     1860

gcaacaatac atcacaacag gccaccccca agatccttgt gtgcatctga ctcaatatag     1920

aataggggtc tggatgaggg ttgaaacaga caccccaggc tgctctaagt tctatacagg     1980

agagaccaaa tggcaagcag ttcttccact gatcttcccc gtccccatcc agaactgcta     2040

gactttttcc agtgaaccca tgagcagcca gcattgccct gaagggttta gaatccagtt     2100

atgactttaa atatcttttt ggtttagaaa aaaggaaaga ttgttaatct cgtgagcaca     2160

ggataatggt aataacacct tatgcctgta taggccactt tacctcctcc taccacgatt     2220

tatttaactt ccccaccc                                                   2238


<210> 464
<211> 1566
<212> DNA
<213> Homo sapiens

<400> 464
ctctctcccg gcctgcgggc cgcttcccac cacagacccc gccccgcgcc ctacccatca       60

cgcgtccccg gtccggctcc ggcgctcacc tacccccggc aggcgccgcc cccgtgccgt      120

ccctcccgga agcgccggcg gagcgtcctc gcatggagcg cgagcccagc gcctcggagg      180

ccgcccccgc ggcggccgcg ctcttcgcct ggggtgcaaa tagctatggg caacttggcc      240

tcggccataa ggaagatgtg ctgttgcccc agcaactgaa tgacttctgt aaacccagga      300

gtgtcaggag gatcacagga ggagggggcc actctgcagt tgtcacagat ggaggagacc      360

tctttgtttg tggcctgaac aaagatgggc aactggggct tggtcacaca gaggatatcc      420

catattttac cccctgcaaa tccctctttg gctgtcccat ccaacaggtg gcctgtggct      480

gggattttac gattatgctc acagaaaatg gtcaagttct atcatgtgga tccaactcct      540

ttggccagtt aggagttcct catggacctc gaagatgtgt ggttccccag gccattgagc      600

tccataaaga gaaggttgtt tgtattgctg ctggactgag gcatgcagta gctgctacag      660

cgagtggcat cgtgttccag tgggggactg gtttggcatc atgtggacga cggttgtgcc      720

ctgggcagac tcttccattg tttttcacag caaaggaacc aagcagagtg acaggtctag      780

agaattctaa agcaatgtgt gttcttgctg gctcagacca ctcagcttca ttaacagatg      840

caggagaggt gtatgtttgg ggaagcaaca agcatgggca actggctaat gaggctgctt      900

tccttcctgt gccccagaaa atagaagcac attgtttcca gaatgaaaag gtcactgcca      960

tctggagtgg atggacacac ctggttgctc agacagaaac tggcaagatg tttacctggg     1020

gccgagcaga ctatggtcag ctagggagga agttggagac ttatgaaggc tggaaactag     1080

aaaagcaaga ttcatttctc ccctgttcaa gaccaccgaa cagcatgcct tcgtctccgc     1140

attgcttaac tggagcaact gaggtctctt gtggctcaga gcataatttg gcaataattg     1200

gtggagtgtg ttactcttgg ggctggaatg agcatggcat gtgcggagat ggcactgaag     1260

ccaacgtctg ggccccaaag ccggtgcagg ctctgctgtc atcgtcagga ctccttgtgg     1320

gctgtggggc tggccactcc ttggccctct gccagctgcc agctcaccct gcattggtcc     1380

aggaccccaa ggtcacctac ctttccccag atgccatcga ggacactgaa tctcagaaag     1440

ccatggacaa agagagaaac tggaaggaaa gacaatcaga aacttcaacc caaagccaat     1500

ctgactggtc cagaaatggg ggactgtgat agagaatctt taataaagtg gcttttccca     1560

ccaaaa                                                                1566


<210> 465
<211> 3481
<212> DNA
<213> Homo sapiens

<400> 465
agtcgtgcga cgccgggcgg ttgcgtgtgg tgcgcggggg cgcgggctgc gtgtggcgcg       60

gggcggggcg cggctggtgc gcttgagaag cgatggcggc ggcctgaact cacctaacac      120

cgcagcagca accgggcccg gccaggttcg gcgttccgtg agtgaacgat ttagaaatct      180

ggactggcca gtgacctctg ggcttgccat tccagcctgg tataacctct ggctccatgg      240

gcagctactg gctcctacag accggatgaa gcagactgga gacacaagtg gagaaaacct      300

ccagctggca aatcctcaga gtgtaggcct ctggctgcca gtcctgccca gcctgcctca      360

tggagaggat gaattggctg agcagactgg cctcccgggg ccctgggcac cgtatacctc      420

aaggggccaa tctccaaacc ccagtcatgg ctgatcccga gacctgcctc atggtcttca      480

agaatcactg gtcccaggtg gtgcgaatcc tggagcggca aggccctcgg gcagctcctg      540

ggggtgcaga cgatctcagt gctgtgcgca accacactta ccagatgttg acactgctgg      600

cagaggaccg tgcagttccc tcggccccca caggccctgg gcccctgctg gagtttgctc      660

tgcacgagga tctgctgacc cgtgtgttga catggcagct gcaatgggat gagcttgggg      720

atggggtcga ggaacggcgg gctgagcaac tgaaactatt tgaaatgcta gtgagcgaag      780

ctcgccagcc actgttgcgg catggtccag ttcgtgaggc tctgctcacc ctgctggatg      840

cctgtggccg ccctgtgccc agtagcccag cactggatga aggcttggtg ctacttctca      900

gccagctgtg tgtttgtgtg gcccaggagc cttcattgct cgagttcttc ctgcagccac      960

ctcctgagcc tggagccgct ccccgtcttc ttctcttttc tcgccttgtc ccttttgtgc     1020

atcgagaggg caccctgggc cagcaggccc gtgatgccct acttcttctc atggctttgt     1080

cagctgggag ccccactgtg ggccgctaca tcgcggatca ctcttacttc tgcccggtgc     1140

tggccacagg gctcagtgcc ctgtactcat cactgcctcg aaagattgag gttccagggg     1200

atgattggca ctgtctgcga cgggaagact ggctgggagt gccagccctt gcactcttca     1260

tgagttccct ggagttctgc aatgcagtaa ttcaggtggc tcaccccctg gtgcagaagc     1320

agttggttga ttatatccat aatgggttcc tggtgcctgt catgggtcct gccttgcaca     1380

agacctctgt ggaggagatg atcgccagta ccgcctatct ggaacttttc ctacggagta     1440

tctcagagcc tgctttgctc cgtaccttcc tgcgattcct gttgttgcac cggcatgaca     1500

cccacaccat cctcgacacc ctcgttgctc gtattggcag taactcccgg ctctgcatgg     1560

tctctctgag tctcttcagg accctcctga acctcagctg tgaggatgtc ctgctgcagc     1620

tggttctcag gtatcttgtt ccatgtaacc acgttatgct gagccagaag ccggctgttc     1680

gtgatgtgga cctatatgga cgagcagctg acaagtttct ctccctaatc ccacgctgtt     1740

gtcggcacca cgcccccagc ccacctcgtc cagagcatgc ctcatgggca cgaggtgggc     1800

ctagcagaga gacagggaga agggaggaca tcacgggtcc tggaagccca agtgtggact     1860

cctcttctgt gacgacagta ccccggccct ccacaccatc tcgtctggct ctcttcctgc     1920

ggcagcagag cctgggtggc tctgagtctc caggcccagc cccttgctca ccagggcttt     1980

ctgcatcccc cgcctccagc cctggccgac ggcctacccc tgcagaggag cctggagagc     2040

tggaagacaa ttacctggag tatctgcgtg aggcacgtcg tggtgtggac cgctgtgtcc     2100

gagcctgccg tacctggtct gccccctatg atggcgagcg gccctctcct gagcccagtc     2160

cttttggctc ccggactaag aaacgcagcc tactgcctga ggaggacagg aacaacgtgg     2220

gggaagggga ggaggaagag ctggggagga gggggcgggc tgggggtgca ggggagggcc     2280

ctggtcacct gccccctccc cagctcaatg gagtgccagg atcatggcct gagggggcca     2340

agaaggttcg tctggtgcca aaggagggag ctggggaact gctagagggc atctccgagg     2400

gcatggcagg actagagggc tttgggcagg agctccggga gctagaggtg gcattgagca     2460

atgggggaac tggctcagag tcccccttag aacctccact gccccttgag gaggaggagg     2520

cctacgagag cttcacctgt ccccctgagc cccctggccc cttcctcagc agccctttgc     2580

ggactctcaa ccagctgcca agccagccct tcactggccc cttcatggct gtgctctttg     2640

ccaaactcga gaacatgctg cagaactccg tctatgtcaa cttcctgctg acggggctgg     2700

tggcccagct ggcctgtcac ccccagcccc tgctccgctc tttcctgctc aacaccaaca     2760

tggtcttcca gcccagtgtc aagtccctgc tgcaggtgct gggctctgtg aagaataaga     2820

ttgagaactt tgcggcttcc caggaggact tcccagcact gctgtccaaa gccaagaagt     2880

acctcattgc ccgtggcaag ttggactggg ctgagggccc tgcagcagga cctgccccac     2940

gccgttctga tcccctagtg aagagccgga ggccatcctt gggggagtta ctcctgcggc     3000

atgcacacag tccaaccagg gcccggcagg cggcacaatt ggtccttcag cctgggcgag     3060

acggagcagg acttggccta agtgggggct cccctggggc ttcaactcca gttctactca     3120

cccggggcgg ggcccctgaa cgccaaggtg aggctcttcg agtcaagaat gctgtctact     3180

gtgcagtcat tttccctgaa tttctcaagg agttggctgc catctcccag gctcatgccg     3240

tcacctcgcc tttcttgttg gagacttcag aggaaggatc tggccctctc atctcaggct     3300

gtgggcccct caatccttaa ctttcttcca tggacaatca gggccatggg tggcccgggc     3360

tggggctagg gcacaggctc ctttttatgt ttggaggcag tggcaaaagg actttttaat     3420

ttatttcaga tgaatgtttt atggagaact tgttgcaata tgtataaaag ggaaatctct     3480

a                                                                     3481


<210> 466
<211> 8544
<212> DNA
<213> Homo sapiens

<400> 466
cacgcactac gggttggcgc cagagtcaaa aggcgtcggc cctctggcaa gatggctgct       60

gcggaggcgt tggagcgcgg aaatctggaa ccgggatggc gacgtctaca ctgagtcgga      120

ggcgaaggag cttactccac gggaacagcc tctagataat ctgagttgtt gaaaatacga      180

agcctgttac tcgtgaacag tggctgacaa cagtgttgtt gtgagcctgg ctgtctgctt      240

ggacccagag gtttcgtctg ccagggtttt tggttgtatt taggatttca gggaaaagtg      300

tccaagcttt cagtgttgga gcaggtatgg acgacaaagg cgacccgagc aatgaggagg      360

cacctaaggc catcaaaccc accagcaaag agttcaggaa aacatggggt tttcgaagga      420

ccactatcgc caagcgagag ggcgcagggg acgcggaggc tgacccactg gagccgccac      480

ccccacagca gcagctgggc ctgtccctgc ggcgcagtgg gaggcagccc aagcgcactg      540

agcgcgtgga gcagttcctg accattgcgc ggcgccgcgg caggaggagc atgcctgtct      600

ccctggagga ttctggtgag cccacgtcct gccccgccac agacgccgag acagcctccg      660

agggcagcgt ggaaagcgct tctgagacca gaagcggccc ccagtctgct tccacagctg      720

tgaaggaacg accagcctct tctgaaaagg tgaaaggagg ggatgaccac gatgacacct      780

ccgatagtga cagcgatggc ctgaccttga aagagcttca gaatcgcctt cgcaggaagc      840

gggaacagga gcccactgag aggcccctga aagggatcca gagtcgcctg cggaagaagc      900

gccgggagga gggtcccgcc gagactgtgg gctccgaggc cagtgacact gtggagggcg      960

tcctgcccag taagcaggag cccgagaacg atcagggggt tgtgtcccag gctgggaaag     1020

atgacagaga gagtaagttg gagggaaagg cggctcagga catcaaagat gaggagcctg     1080

gagacttggg ccgaccgaag cctgaatgtg agggttacga ccccaacgcc ctgtattgca     1140

tttgccgcca gcctcacaac aacaggttta tgatttgctg tgaccgctgt gaagaatggt     1200

ttcatggcga ttgtgtgggc atttctgagg ctcgagggag gcttttggaa aggaatgggg     1260

aagactatat ctgcccaaac tgcaccattc tgcaagtgca ggatgagact cattcagaaa     1320

cggcagatca gcaggaagct aaatggagac ctggagatgc tgatggcacc gattgtacaa     1380

gtataggaac aatagagcag aagtctagcg aagaccaagg gataaagggt agaattgaga     1440

aagctgcaaa tccaagtggc aagaagaaac tcaagatctt ccagcctgtg atagaggcgc     1500

ctggtgcctc aaaatgtatt ggccccgggt gctgtcacgt ggcgcagccc gactcggtgt     1560

actgcagtaa tgactgtatc ctcaaacacg ccgcagcgac aatgaagttt ctaagctcag     1620

gtaaagaaca gaagccaaag cctaaagaaa agatgaagat gaagccagag aagcccagtc     1680

ttccgaaatg cggtgctcag gcaggtatta aaatctcttc tgtgcacaag agaccagctc     1740

cagaaaaaaa agagaccaca gtgaagaagg cagtggtggt ccctgcgcgg agtgaagcac     1800

tcgggaagga agcagcttgt gagagcagca cgccgtcgtg ggcgagcgat cacaattaca     1860

atgcagtaaa gccagaaaag actgctgctc cctcgccgtc actgttgtat aaatccacga     1920

aggaagacag gaggtccgag gagaaagcgg cagccatggc agcctcaaag aaaacagccc     1980

ctccaggctc cgcggtgggc aagcagcctg cacctagaaa cctcgtgcca aagaagtctt     2040

cttttgctaa tgtggcagca gccacaccag ccattaaaaa gccaccctca ggtttcaagg     2100

gcaccatccc caagaggcca tggctctccg ctaccccatc gagtggtgct tcagctgcca     2160

ggcaggccgg accggcacct gcagcggcaa cggctgcctc caagaagttc cctggctccg     2220

ctgctttggt gggagccgta aggaagccag tggtaccttc tgttccaatg gcctcgccag     2280

ccccaggacg ccttggggct atgagtgctg caccatcgca gccaaattca caaattcggc     2340

aaaatatcag acgctcctta aaagagattt tgtggaaaag agtcaatgac agcgatgact     2400

taatcatgac agaaaacgaa gtaggaaaaa ttgccctcca tattgagaag gagatgttta     2460

acttgtttca agttacagat aatcgctaca agagtaaata tcgcagcatc atgttcaacc     2520

tgaaggaccc taaaaatcag ggactcttcc atcgtgttct gcgtgaggaa atctctttgg     2580

cgaaacttgt gagactgaag ccagaagaac ttgtatctaa agagctttcc acgtggaaag     2640

agaggccagc gagatctgtg atggagtcca gaactaaact gcacaatgaa agcaagaaga     2700

cggcccccag gcaggaggcc atccccgatc tggaggactc tccgccagtg tcggattcag     2760

aggaacagca agagtcagca cgtgctgtcc ctgagaagag cacagcgccg cttctcgacg     2820

tcttcagcag catgttgaaa gacaccacca gtcagcaccg cgcacacctc ttcgatctca     2880

actgtaaaat ttgcacaggc caggttccct ccgcagaaga tgagccagct ccgaaaaaac     2940

aaaaattgtc agcttctgtt aagaaagaag acttaaaatc aaagcatgac agctctgcac     3000

ctgacccagc tccggattca gctgatgagg tgatgccgga ggctgtgcct gaagttgcct     3060

ctgagccagg cctagaaagt gcttctcatc caaatgtgga cagaacgtat ttccctgggc     3120

ctccaggaga tggccatccc gagccctccc cgctggaaga cctgtccccc tgcccagcct     3180

cctgtgggag cggggtggtc accaccgtca cagtgtccgg ccgggacccc aggaccgctc     3240

caagcagttc atgcacagcc gtggcctccg cagcatcccg cccagacagc acccacatgg     3300

tggaagccag acaggatgtg ccgaagcctg tcttgacttc tgtgatggtg cccaagtcca     3360

tactagctaa gccatcctca tctcctgacc caagatacct gtcagttcct ccgtcaccaa     3420

atatcagcac ttcagaatca cgttcccctc cagagggaga cacgaccctc tttttgtctc     3480

gactcagcac catttggaaa ggatttatta acatgcagag tgtggcaaaa tttgtcacta     3540

aggcgtatcc tgtctctggg tgttttgatt acctcagtga ggatttgcct gacacaattc     3600

acattggtgg gaggatcgca ccgaagacag tttgggatta tgttggcaaa ctcaagtctt     3660

ctgtgtctaa ggagctctgt ctgatccgct tccaccccgc cacagaggaa gaggaggtcg     3720

cctatatctc tctctactcc tatttcagca gccgtggccg ctttggtgtt gtagctaata     3780

acaacaggca cgtcaaggac ctctacctga tcccgctgag cgcccaggac cctgttccat     3840

ccaaactctt gccctttgag ggaccaggtc ttgagtcacc acgtccgaat ataattcttg     3900

ggttagtaat ctgccaaaaa atcaaacgtc ccgcaaacag tggagagtta gacaagatgg     3960

acgaaaagcg gacccgactt caaccggaag aagcggacgt tccggcctat ccaaaagtag     4020

ccacagtccc gcagtcggaa aagaagccct ccaagtatcc actctgctct gcagacgcgg     4080

ctgtcagcac cacacctcct gggtcgccgc cgcctccgcc ccctcttcca gaaccaccgg     4140

tgctaaaagt gctgtcatcc ctcaaacctg cagcccccag cccagccaca gcagccacaa     4200

cagcagcggc agcctccacg gcagcttcct ccaccgcttc gtctgcttcc aaaacagcat     4260

caccgctgga gcacatcctg cagactctct ttggaaagaa gaaatcattc gacccgtccg     4320

ccagagagcc tcccgggtcc accgcaggtc tcccccagga gcccaaaacc acagcagagg     4380

acggggtgcc ggcacctccg ttgttagatc cgatcgtcca gcagttcggt cagttctcaa     4440

aagataaggc tctagaggaa gaggaggacg acaggccata cgaccctgag gaggagtacg     4500

acccggagag ggccttcgac actcagcttg tggagcgagg gcggcgccac gaggtggaaa     4560

gggctcctga agcagctgca gccgagcggg aagaggtggc ctatgacccc gaggatgaga     4620

ccatcttaga agaagcgaaa gtgactgttg atgacctgcc caacaggatg tgtgccgacg     4680

tgagaaggaa ctccgtggag aggcctgccg agccggtggc cggggctgcg acgccctccc     4740

tggtggagca acagaagatg ctagaagagc tgaacaaaca gatcgaggag cagaagagac     4800

agctggagga gcaagaagaa gctctcaggc agcagagggc cgccgtcggg gtctccatgg     4860

cccacttctc ggtgtcggac gccttgatgt ctccaccacc aaagtcgtcc ttgcccaagg     4920

cagagctgtt ccagcaagag cagcagtctg cagacaagcc cgcctcactg ccccccgcca     4980

gccaggcgtc aaaccacagg gacccccggc aggcgaggcg cctggccact gagaccggtg     5040

agggggaggg ggagcctctc tccaggctct cggcacgtgg tgcccagggt gccctgcccg     5100

agagagatgc ttccaggggt ggcctcgtgg gccaggcgcc catgccagtc ccggaggaaa     5160

aagagccagc ctcttccccc tgggcttcgg gcgaaaagcc cccagcgggg tccgagcagg     5220

acggctggaa ggcagagcct ggggagggca cccgccccgc cacggttgga gacagctcgg     5280

ccaggcctgc ccggagggtg ctgctgccca caccgccttg cggcgccctg cagcccggct     5340

tcccgctgca gcacgacggt gagagggacc ctttcacctg cccggggttc gcgtcgcagg     5400

acaaggctct cggctcagcc cagtatgagg acccaagaaa tcttcattct gctggaagga     5460

gcagcagccc tgcaggtgaa acagaggggg acagagagcc acaggccaga cccggcgagg     5520

gcaccgcccc gctcccccca ccaggacaga aagtgggggg ctctcagccc ccgtttcagg     5580

gtcagcggga acctggacct catgctttgg ggatgtcagg gcttcacggc cccaatttcc     5640

cgggaccaag ggggccagcc cctccgtttc cagaagagaa tatcgcttct aacgatgggc     5700

cacgagggcc tccgccagcc agattcggag cccagaaggg gcccatccct tccttattct     5760

cggggcaaca tgggccacct ccttatgggg acagcagagg cccctcaccc tcttaccttg     5820

gtggaccacg aggagtggca ccatcccaat ttgaagaacg caaggatccc catggggaga     5880

agagggagtt ccaggacgcc ccgtataacg aggtgacggg cgcccccgcc cagtttgaag     5940

ggacagagca agccccattt ctgggaagca gaggcggcgc gcctttccag ttcggaggcc     6000

agagaaggcc actgctgtct cagctgaaag gcccccgagg cggcccccct ccctctcagt     6060

ttggaggtca gagaggacca ccccctggtc atttcgtggg cccaagaggg ccccatccta     6120

gtcagtttga aactgcccgg ggccctcatc ccaaccagtt tgaaggaccc agaggccaag     6180

cgcctaactt tatgccaggt cccaggggca ttcagcctca gcagttcgaa gaccagaggg     6240

tccattcacc accaagattc acaaaccaaa gggcgcctgc acccctgcag tttggtggac     6300

tacgggggtc cgcacccttt tctgaaaaaa atgagcagac cccttcgcga tttcacttcc     6360

agggccaggc cccgcaggtg atgaagccgg gccccaggcc cctgctggag cttcccagcc     6420

accccccgca gcaccggaag gaccgctggg aggaggccgg gccgccctcc gcgctctcct     6480

ccagtgcgcc cggacagggc cccgaggccg acggacagtg ggcatcggcc gacttccgag     6540

aggggaaagg ccacgaatac agaaaccaga ctttcgaagg gaggcagaga gagcggtttg     6600

acgtggggcc caaagagaag ccgctggagg agcccgacgc ccagggccgg gcgtccgagg     6660

acaggaggag agagcgcgag cgcggccgaa actggagccg agagcgggac tgggaccggc     6720

cccgggagtg ggaccgacac cgggacaagg actccagccg ggactgggac agaaaccggg     6780

agaggagcgc caaccgcgac cgagagcgcg aggccgaccg gggcaaggag tgggaccgca     6840

gccgggagcg gagcaggaac cgagagcgcg agcgagaccg gaggcgcgac cgggaccggt     6900

cccggagcag agagcgggac cgagacaagg ccagggacag ggagcggggc cgcgaccgca     6960

aggaccggag caagagcaaa gagagcgctc gggacccgaa gcccgaggcc tcgagggcct     7020

ccgacgctgg caccgcctcg caggcctaga cgccccggcc gggcagagac cctttttaaa     7080

gccacgttcg taagatgcgt tgaacaaata gcttttgaaa tagccacgat cttagattca     7140

ggatagaata ttctggactt aaacattact gtaattttgt gtaaatggtt tcttacaaga     7200

tttcacatct ttacaattct gatgcttttt taaaaaaact aaactttaat atttccattt     7260

aaaattaaaa gaaatgggaa attgcctacg gagcatattg cttttcagat catagttatc     7320

ttttccaata actttattgt aaattttaag ggagtttcgt tggaccctag agccatacct     7380

tcactgacat ctcatccgtt tgtgtttcca aaagctgctt ttacaggtct tagccgccgc     7440

cccggaggcc ggtgtgggcg tgacctgcag gcgtccaccc tgcggctacg ggagaagtct     7500

tagtagcttg tatctggagt cttgagaaac acaaacctta caaatgcatc tttcttttgt     7560

cataaaattg gaattacaat tttcaactgg gaaacagaaa cacatttctt agcgtgctca     7620

gattttatat atcaccttat caattttttc caaaacatga tttaaagcaa catctgtcct     7680

agtataattg ttgcatttta aataacaatt tattgaaaaa tgttaagttt taccagccta     7740

aaaaaagtaa caaaccaatt aagtgtactt tgggggcagg gaggagtcct tgatttgaat     7800

aatcaggagt tttgttggtc cagtttcgcc ttctgagcag ttcttctgta tcccgggaaa     7860

agtacgctcg gccccaaact ggtatttgtc agacgataca tgtaaaagtt tgtccttgaa     7920

cgtggaacaa gacttgtgta aagtctgaga cgggaactag tgatcactag ctcaagaact     7980

gcaaatgaga caggaagctg ttcactgtga aacagtctct tgcttgtcgt gtatttttcg     8040

agtacttctg aagtgtgaag taaaaaaatc tggctaattt atttgtacaa atacactttg     8100

ataatttttt atattttcat aaacttttac agatgtaaaa ttaaagaact tcacttgttc     8160

tttggagtct gttattccat tgtacgtcac tacagatttt tcactttata gcacagattt     8220

tttaagttaa gaaaacattg agaatgtatc agtttgagat gtttggtgtt gaaagccaag     8280

tgtccatagg ttaaattaca ttaaagtagg tgtcacgttc caacatctag tacgatgaga     8340

aggttttgtt tgtttaacat ataaagcaaa tttttctaat ttaaatacac aaatgtaaaa     8400

atcaagtgtg tttctttagt ttacttgata gagattcctg tacattgtat tttatattgc     8460

ggaggcttat atcactgtac atgagaacat ggaacgacct aggttttgtt actcgcagta     8520

gaataaacag ctacaggaag tttc                                            8544


<210> 467
<211> 1961
<212> DNA
<213> Homo sapiens

<400> 467
cacgcactac gggttggcgc cagagtcaaa aggcgtcggc cctctggcaa gatggctgct       60

gcggaggcgt tggagcgcgg aaatctggaa ccgggatggc gacgtctaca ctgagtcgga      120

ggcgaaggag cttactccac gggaacagcc tctagataat ctgagttgtt gaaaatacga      180

agcctgttac tcgtgaacag tggctgacaa cagtgttgtt gtgagcctgg ctgtctgctt      240

ggacccagag gtttcgtctg ccagggtttt tggttgtatt taggatttca gggaaaagtg      300

tccaagcttt cagtgttgga gcaggtatgg acgacaaagg cgacccgagc aatgaggagg      360

cacctaaggc catcaaaccc accagcaaag agttcaggaa aacatggggt tttcgaagga      420

ccactatcgc caagcgagag ggcgcagggg acgcggaggc tgacccactg gagccgccac      480

ccccacagca gcagctgggc ctgtccctgc ggcgcagtgg gaggcagccc aagcgcactg      540

agcgcgtgga gcagttcctg accattgcgc ggcgccgcgg caggaggagc atgcctgtct      600

ccctggagga ttctggtgag cccacgtcct gccccgccac agacgccgag acagcctccg      660

agggcagcgt ggaaagcgct tctgagacca gaagcggccc ccagtctgct tccacagctg      720

tgaaggaacg accagcctct tctgaaaagg tgaaaggagg ggatgaccac gatgacacct      780

ccgatagtga cagcgatggc ctgaccttga aagagcttca gaatcgcctt cgcaggaagc      840

gggaacagga gcccactgag aggcccctga aagggatcca gagtcgcctg cggaagaagc      900

gccgggagga gggtcccgcc gagactgtgg gctccgaggc cagtgacact gtggagggcg      960

tcctgcccag taagcaggag cccgagaacg atcagggggt tgtgtcccag gctgggaaag     1020

atgacagaga gagtaagttg gagggaaagg cggctcagga catcaaagat gaggagcctg     1080

gagacttggg ccgaccgaag cctgaatgtg agggttacga ccccaacgcc ctgtattgca     1140

tttgccgcca gcctcacaac aacaggttta tgatttgctg tgaccgctgt gaagaatggt     1200

ttcatggcga ttgtgtgggc atttctgagg ctcgagggag gcttttggaa aggaatgggg     1260

aagactatat ctgcccaaac tgcaccattc tgcaagtgca ggatgagact cattcagaaa     1320

cggcagatca gcaggaagct aaatggagac ctggagatgc tgatggcacc gattgtacaa     1380

gtataggaac aatagagcag aagtctagcg aagaccaagg gataaagggt agaattgaga     1440

aagctgcaaa tccaagtggc aagaagaaac tcaagatctt ccagcctgtg atagaggcgc     1500

ctggtgcctc aaaatgtatt ggccccgggt gctgtcacgt ggcgcagccc gactcggtgt     1560

actgcagtaa tgactgtatc ctcaaacacg ccgcagcgac aatgaagttt ctaagctcag     1620

gtaaagaaca gaagccaaag cctaaagaaa agatgaagat gaagccagag aagcccagtc     1680

ttccgaaatg cggtgctcag gcaggtatta aaatctcttc tgtgcacaag agaccagctc     1740

cagaaaaaaa agagaccaca gtgaagaagg cagtggtggt ccctgcgcgg agtgaagcac     1800

tcgggaagga agcagcttgt gagagcagca cgccgtcgtg ggcgagcgat cacaattaca     1860

atgcagtaaa gccagaaaag actgctgctc cctcgccgtc actgttgtat aaatgctctg     1920

gtaagtattc gtattctctt catcccagtc tgattgcata g                         1961


<210> 468
<211> 1731
<212> DNA
<213> Homo sapiens

<400> 468
gtcctgagag tcagccctcg ccgctgcagc ctcggcgccc ggccggccgg ccatggagcg       60

ccccccgccc cgcgccgccg gccgggaccc cagtgcgctg cgggccgagg cgccgtggct      120

gcgcgcggag ggtccggggc cgcgcgccgc gcccgtgacg gtgcccacgc cgccgcaggg      180

ctcttccgtg ggcggcggct tcgcgggctt ggagttcgcg cggccgcagg agtcggagcc      240

gcgggcctcg gacctggggg ccccccggac gtggacgggg gcggcggcgg ggccccggac      300

tccgtcggcg cacatccccg tcccagcgca gagagccacc ccaggaaaag cccggctgga      360

cgaggtcatg gctgccgctg cccttacaag cctgtccacc agccctctcc ttctgggggc      420

cccggttgca gccttcagcc cagagcctgg cctggagccc tggaaggagg ccctggtgcg      480

gcccccaggc agctacagca gcagcagcaa cagtggagac tggggatggg acctggccag      540

tgaccagtcc tctccgtcca ccccgtcacc cccactgccc cccgaggcag cccactttct      600

gtttggggag cccaccctga gaaaaaggaa gagcccggcc caggtcatgt tccagtgtct      660

gtggaagagc tgcgggaagg tgctgagcac ggcgtcggcg atgcagagac acatccgcct      720

ggtgcacctg gggaggcagg cagagcctga gcagagtgat ggtgaggagg acttctacta      780

cacagagctg gatgttggtg tggacacgct gaccgacggg ctgtccagcc tgactccagt      840

gtcccccacg gcctccatgc cgcctgcctt cccccgcctg gagctgccag agctgctgga      900

gcccccagcc ctgcctagtc ccctgcggcc gcctgccccg cccctgcccc cgccccctgt      960

cctgagcacc gttgctaacc cccagtcctg tcacagtgac cgtgtctacc agggctgcct     1020

gacgcccgcc cgcctggagc cgcagcccac ggaggtcgga gcctgcccac ccgccttgtc     1080

ctccaggatc ggagtcaccc tgaggaagcc ccgcggcgac gcgaagaagt gccggaaggt     1140

gtatggcatg gagcgccggg acctctggtg cacagcctgc cgctggaaga aagcctgcca     1200

gcggttcctg gactaagtcc ggctcgttca agaacataag ctaccacctt ctccctcccc     1260

accccctcca ggcccggggc tgaaacagcc cgaggacagc cccaggggct ggctttcacc     1320

agctgcaggg tctgctttta cttggggtgg gggggcgggg ctgaccctga accctccccc     1380

ccgccaggtc ggggaggggt cccaccactc aaagtgcctc taaagaaacc agctttttgc     1440

actaaagcca aaccacaccg ctgtcccctt agccccaagg gccctggggg cagccaccct     1500

cccgcctgtc ggcccgtaga tttatcaagg gtgttatggg cccagctttg gggggccagt     1560

cccgatgcac tttgaggggt gttggagagg ggactccccc actcgcactt aactcaacgg     1620

ctctcgggcc ctggggctgt ttttaccatg tttgtttttg aagctcaggt gtctcacgtc     1680

tgggctgcac caggcgaaga gagaaattaa agatttgagg tttttccaga a              1731


<210> 469
<211> 3039
<212> DNA
<213> Homo sapiens

<400> 469
atgctgagat tctgtgcagg cctttctgac tttgcaccag tggcagttcg cagcctccag       60

gacttggctc gcatcgccat ccggggcacc attaaaaaga ttattcatca ggaaactgtg      120

agcaaaaacg gaaacggact aaagaacacc cccaggttta aacgaaggag agttcgccgc      180

cgtcgaatgg aaacgattgt ctttttggac aaagaagtct ttgccagtcg gatttccaac      240

ccctcagatg acaacagctg tgaagacttg gaagaggaac ggagggaaga agaagagaag      300

accccgccgg aaacaaagcc agacccccca gtgaacttcc tacgccagaa ggtcctgagc      360

ctccctctgc cagatcccct gaaatactac ttgctttatt acagagaaaa ataagtctcc      420

tgtttgaaag ggggaaatag gaagagcaga ttgctgagtg tgaagttcgt gctgcctgtg      480

tgctgttgaa gggtcacctg gaggcagacg ttgtggggaa gggaactgct gggctcatcc      540

acaccatggt tttcttctag ttcctgattg acctctaaaa ttctattcag ttgtatgatt      600

tgtttacata gttccacaag accttcattg catagaagat tgttttccca aagtggagag      660

aatcttcata gagaaaaaga gaaggctgtt tctttttcgg ctctgacgaa acactgaagt      720

ctgcgtaaga gagactgttt gatgaccgtc cctcatgcaa catgcacggt actcactaaa      780

aatgaaaact gaagtggaaa ctaacctgtg ttgcttataa agtgtgaaag cacaagctta      840

taaatgtata aaatcttttc tgggtgtgac gcacctgcgt ccaagtttga atttttatga      900

tatgtaccac ttaattactg gcactgagta tcactgaatt tcttagtttt ctagtgggga      960

aacattattg agaagccctc ccttatttta agtaagttga ttaaatctta tgtgagttgc     1020

cagttgtaat ttttcaaagg aaaaattttg atggggtgga ggaatgaatt gccagataat     1080

ctttctggaa ttccgagaga attccaaaga gggttttttt tttttttttt aggacatctt     1140

ttgatacctt taaaagaacc actgtcaagt aatccttaaa agaatatctt ggaaaaggaa     1200

acagattttt tcctgtgtgt aagcaataag tgaagttaca tttgccctaa ccctagggat     1260

gattctttac ccagttttaa agcccatcat ggtattctaa ggtgttgaca ccctccatcc     1320

tcagagcagg tcgaaaatat taaatagact ggggactcta tgatgggcag cctgtgcttt     1380

ttgacttcag tttgctattt ttctgtgatc acattagtac tgattcatag attctatctt     1440

ttataattct ggagaaaaag atttgttagt tttgtaattt ttttgtaaga ccaaatgtat     1500

gtattttagt agctccattg catgagaaga gtgtaactca cactgacttg tgatatcagc     1560

cttctctggg ccttgtgtgt ggagagcttt ctatcttacc aagtggtagg gctaaaagaa     1620

caacagcctt tttggtagtc acatagcaga atgatcagag ttacattgct tattccaaaa     1680

cattggttct ttttaaaaca ttttttttta cccaaagaaa agaataatag aaattactaa     1740

caataaatat aaattcagag tgttgatata ggattcagta tccagagttt atttttaatc     1800

ttaatcctca gcttcttggg agttgctggg cttcagtgtc tctgtggttt caccagctta     1860

gcttgagctc tggttatttt ggatcttttc tgcttttttt aagtaactga gtcattttta     1920

ccacacagtc cagtttgcat gtatagctag gaaacatgta ttgctctaga ttgggcagtt     1980

taagtcattt taaagaaagt tagttcatag ttgttgcctt ttaactcata gtcaagcttc     2040

agtctttcaa agagaaatgt gtgattttca tttacttgct gatattttgt agtttggaga     2100

tccttgtggg cattattcta actgatacgt agacacttac ttggaaattt ttggacatta     2160

tattaaatga gtgctatctg tgaaattggt tatattaggt ggcttgacta atgttttttc     2220

tataattgta tatggactgc atttttaaaa aaaccgcatt tgcctttatg ctagattgta     2280

aaaaattata ttagaatgca taagacatgt ttttccttca tatgctagac ttttcctagc     2340

atttcgtatt tctgtgttgt cagtgtgtga tttttaaacc ggaatttggt ttaaaaaaaa     2400

tctggtggta atatatgtga gaaatacttt ggtgtttacc ttatgaaaat aaaggattgt     2460

aagtaaagtt tcctgcgcac cttataccag aattcagtat aatacactac tttctgtttt     2520

caaacagata aatcataata tagtctgtat tatctgtaag atctgtcttg taaaccacat     2580

tcttgacaac tatttgcttt tgagtagttt gtattttaat atgtgacttt tgtcttgaaa     2640

agtagtaaag ccatagactt gtgcaaaaca agtttcaagt ttatagatat taagtttgta     2700

atgtgagcat caaatgtgta tgtaaaaata ctttttacca gtctggaact tgggaaaatc     2760

cagggaattt gaaacataga ttttaatgag ctggtaaaca caaatcatgt caataaaggt     2820

agtcaggata ttttatcctt agcattgctt ctgcatcctg tgtaggattc caattcttga     2880

atatgttctt ttcaaaatct taagaaaaga accttttttc tttattaaca tcatgtgttt     2940

actttcagca aatatttgta ttactgcttg attctgtgac agtcacaata gatgtagaga     3000

aggcattatt tttcattaat aaatgtgaaa ttggaatgg                            3039


<210> 470
<211> 2505
<212> DNA
<213> Homo sapiens

<400> 470
atgaggctcc tggatgggaa acagacttcc aggtactcag agaatgcctg cgagaagaag       60

attttctcta tctacggaca ctacccggtg gtccgggccg ctctgcgaag gaagggctgg      120

gtagagaaga agttccactt tttgcccaag gtcattccgg atgtcgagga tgaaggcgcc      180

cgggtcaatg atgatacatg tgccaaagtc aaagaaaatc aagaaatggc tttggagaaa      240

acagacaaca tccacgacgt gatgtctagg ttggtaaaaa atgagatgcc gtacctcctc      300

tggaccatca agagggacat cattgactat cacagcctga cctacgacca gatgctgaac      360

cactacgcaa agacagcctc cttcaccacc aagatcgggc tgtgcgtgaa catgcggagc      420

ctgccctggt acgtcccggc caaccccgac tccttcttcc cacgctgcta cagcctctgc      480

accgagagtg agcagcagga gttcctggaa gacttccggc gcaccatggc atccagcatc      540

ctcaagtggg tggtcagcca ccagagctgc agcaggagca gcagaagcaa gcccagggac      600

cagagggagg aggccgggag cagcgacctg agcagcaggc aagatgctga aaatgctgag      660

gcaaagctca ggggcctccc ggggcagctt gtggacatcg cgtgcaaggt gtgccaggcc      720

tacctggggc agctggagca tgaggacatc gacacgtcag cagatgccgt ggaggacctc      780

actgaggccg agtgggagga cctgacccag cagtactact ccctcgttca ggtgcctttg      840

gggagtagca ttgtcttgtg catcttcaaa atccagaagg ttatgatgtc atttgagccc      900

cccacagccc gagacaggca gtgccaggct ctgctgaata gaatcacgtc tgtgaaccct      960

cagacggaca ttgacgggct ccggaacatc tggattataa agcccgcggc caagtcccgg     1020

ggccgaggtg agtcccctga catagtgtgc atggaccgtg tggaggagat cctggagctg     1080

gcagctgcag accaccctct ttccagggac aacaagtggg tggtccagaa gtacatcgag     1140

acgccgctgc tcatctgtga caccaagttc gacatcagac agtggttcct cgtcacggac     1200

tggaaccccc tgaccatctg gttctacaag gagagttact tgcggttctc aactcagcgc     1260

ttctccctgg acaagctgga cagcgccatc cacctgtgca acaacgccgt ccagaagtac     1320

ctgaagaatg atgtgggccg cagccccctg ctgcccgcac acaacatgtg gaccagcacc     1380

aggttccagg agtacctgca gcgccagggc cgtggcgccg tgtggggcag cgtcatctac     1440

ccgtccatga agaaggccat cgcccacgcc atgaaggtgg cccaggacca cgtggagcct     1500

cgcaagaaca gctttgagct ctacggggct gacttcgtcc ttgggaggga cttcaggccc     1560

tggctgatcg agatcaattc cagccccacc atgcacccgt ccacgccggt cacggcccag     1620

ctgtgtgcac aggtgcagga ggacaccatc aaggtggccg tggaccgcag ctgtgacatc     1680

ggcaacttcg agctcctgtg gaggcagccg gtggttgagc cgcccccatt cagcgggtcc     1740

gacctctgcg tggcgggcgt cagtgtgagg agagccagga ggcaggtgct gcccgtctgc     1800

aacctcaagg cctcggcctc gctgttggac gcgcagccgc tgaaggcacg gggcccctcg     1860

gccatgccag accctgccca gggaccccca tcaccagctc tccagcggga cttgggactg     1920

aaggaagaga aggggctccc cctggccttg ctggcaccct taaggggggc agccgagagc     1980

ggtggagccg cacagcccac ccgcaccaaa gctgctggga aggtggagct cccggcctgc     2040

ccctgtcgcc acgtggacag tcaggcccca aacaccggtg tccccgtagc ccagcccgcc     2100

aaaagctggg atccaaacca gctaaatgcg cacccgctgg agcctgtgct gcggggcctg     2160

aagacagcag agggcgcgct gcgtccgccg cccggaggaa aaggagaggg cacggtctgc     2220

agccgcctgc cacaccacgg gcaccacgtg gccgcctgcc agaccacggg caccacgtgg     2280

gatggtgggc ctggggtgtg cttcctccgg cagctcctgg catcagaact gcccatgggc     2340

cctgggctgc cgagggaccc ccgagcgccg ccctgcctcg tgtgccgcgg gctgctgcca     2400

cccgccgggc cctgcaagcg ctgccgctcg ttctgcgccg cggtcctgca gggcgcgtcc     2460

ttcgtgcggc tcggcgggcg gagctgcagc ccgcggaccc cgtga                     2505


<210> 471
<211> 2039
<212> DNA
<213> Homo sapiens

<400> 471
aatgacatga cagccattcc gtggccaggg acaccactgc ccaagctgga gaccacgagg       60

attcagggac tgaagccagc atgggaattc ctggtttgag atcagagtcc tgagtacctc      120

gtgggaactt gggcactcat ccgcaggagg tctagacccc cagagaattc cttgagtcta      180

aggcacaggc ccaacatgtg tagcaccagt gggtgtgacc tggaagaaat ccccctagat      240

gatgatgacc taaacaccat agaattcaaa atcctcgcct actacaccag acatcatgtc      300

ttcaagagca cccctgctct cttctcacca aagctgctga gaacaagaag tttgtcccag      360

aggggcctgg ggaattgttc agcaaatgag tcatggacag aggtgtcatg gccttgcaga      420

aattcccaat ccagtgagaa ggccataaac cttggcaaga aaaagtcttc ttggaaagca      480

ttctttggag tagtggagaa ggaagattcg cagagcacgc ctgccaaggt ctctgctcag      540

ggtcaaagga cgttggaata ccaagattcg cacagccagc agtggtccag gtgtctttct      600

aacgtggagc agtgcttgga gcatgaagct gtggacccca aagtcatttc cattgccaac      660

cgagtagctg aaattgttta ctcctggcca ccaccacaag cgacccaggc aggaggcttc      720

aagtccaaag agatttttgt aactgagggt ctctccttcc agctccaagg ccacgtgcct      780

gtagcttcaa gttctaagaa agatgaagaa gaacaaatac tagccaaaat tgttgagctg      840

ctgaaatatt caggagatca gttggaaaga aaggacactg ccttcatccc cattcccttg      900

gttgacacca gcatccaggg ttttccacag gatggtttga tggcctgcat ttgagctaaa      960

gaatgaactt ctgtctgcct cgtggagcca agctactgta ctgagtgctt attcttttgt     1020

acacagctga agaaagataa ggctttgatg ggccacttcc aggatgggct gtcctactct     1080

gttttcaaga ccatcacaga ccaggtccta atgggtgtgg accccagggg agaatcagag     1140

gtcaaagctc agggctttaa ggctgccctt gtaatagacg tcacggccaa gctcacagct     1200

attgacaacc acccgatgaa cagggtcctg ggctttggca ccaagtacct gaaagagaac     1260

ttctcgccat ggatccagca gcacggtgga tgggaaaaaa tacttgggat atcacatgaa     1320

gaagtagact gaaatatcag atttgtcatc aggaatactc tttgtctact gtggtcctgt     1380

gcacgttggc ctcagatgga ctacaggaga ttacaacgta caaggcagat ggagcattga     1440

cgttttcaaa accattattc ctgtgactgg agaggcatca ggagaggtct cgttcgtctc     1500

cagctcataa aatgtagcag catcatcctt gacagtgatg tttttcaggc cctccattga     1560

gaacctgagg aaatctgtaa agataagtgg tgatgttgtt tcaaacgttc agaacagata     1620

ccatcatcct gcctttgtta gctgctgtag ggaaagtgcg ttacagatgt ctgctgacct     1680

cacaagagtg aaaagataaa ctgtgcatgt gtttccactt ccgtttctag tactatttat     1740

ttttaaacta cacttggggt ggcctaatac ctaggaagat gttgctattc acgttagtaa     1800

acagcctaaa gaaactctta ggtttactgc tacatccatt tgtttggaga ggtaactgtt     1860

gtctgtgcct ttttgaaaaa cttccatttg gtacaaaatt tttactccaa caccccctca     1920

acccttttct cagggaccac acctcttctt cccaaggtcc ctgggacttc ctcattcttt     1980

gtggtagtac aatgattggt agcaggtaaa ataaatacat agaaagacta ctgtcaaaa      2039


<210> 472
<211> 1389
<212> DNA
<213> Homo sapiens

<400> 472
ggtgggaggt gaaaggtcat agtcctgttt ggcggccatt tctcttgaaa ctgcggctcg       60

ggacctgcgg tacctgctgt agtcacgagg gacgggcggc ggcctggtcg gcagagagta      120

gcctgcaaca ttcggccgtg gttacgatga gtttacccct caatcccaaa cctttcctca      180

atggactaac aggaaagcca gtgatggtga aacttaagtg gggaatggag tacaagggct      240

atctggtatc tgtagatggc tacatgaaca tgcagcttgc aaatacagaa gaatacatag      300

atggagcttt gtctggacat ctgggtgaag ttttaataag gtgtaataat gtcctttata      360

tcagaggtgt ggaagaagag gaagaagatg gggaaatgag agaatagcat cttttgtggg      420

ggattttttt tatatatatt tctagacaat aaagatttgt ttgtttttca acttgacttg      480

tgaactattt gtattcagat atttacaagc aaagctgaaa tgatgaacca attgggaaag      540

attactcact gaactaatgc tttaaaagcc actgaatttc atttaagttg cttttctttt      600

gtaagcccaa tattcttttt tttcccataa aggataatta tttatatgct ttagatattt      660

ttatgaaggt gaatttcaga ccttttcttg taaaattatc tattagctga gaccttttaa      720

atgcaacttt ttcttttaaa gttatttttg agctactttt aacgtataaa attaaacatt      780

ttcttggtat taataatata ctgtcttatt ttacttagta gtcaataaat tacatgttaa      840

ttctgtgtca atataagcta aatgcacata ttgcagctaa aattgaagca tcttctaaaa      900

attaaaatga ttgtacagac agggcacaac agaaattggg aactgacatt caggctgaag      960

gcatacggtt tgttcactga agagaaaaaa gttctctgaa caaaatgtaa tgtcaaataa     1020

aaaccagtct ccccattatg ttctgagaca taacctcgag gttgagtttt aagcccctca     1080

aaacccttca ggtattttag ggttgtacat tgttaaaatg tatagtccat agtaataaca     1140

gtatgctatg aacttcccta cagatgggtt gagaaaatac atcatttaca ttctcatgtt     1200

gtaagagaat ggccattatt acacttcagt gttcatttac catagtttta tcagtaaact     1260

atctttgtgt atccccaagt gggacaactc aaagtataga agaaagtgtt tagctatatg     1320

gaataatact tatgatatga atacttaaag acttaaaatt tacaaaatac acctaagaca     1380

ttctggtaa                                                             1389


<210> 473
<211> 2136
<212> DNA
<213> Homo sapiens

<400> 473
accctcccag ccccggacag cgcaggctgc ggcttttcgt cctccactga gtcctgccgg       60

tggcccgagc ccggtggcct cccggcgacc ctcggcgcga ggcgacatgg caagcggcca      120

cagcctcctg ctggagaacg cgcagcaagt ggtgctggtg tgcgcccgcg gcgagcgctt      180

cctggcgcgg gatgcgctgc gcagcctggc ggtgctggaa ggcgccagcc tggtggtggg      240

caaagatgga tttataaaag ctattggtcc tgctgatgtt attcaaagac agttttctgg      300

agaaactttt gaagaaataa ttgactgctc tgggaaatgt attctaccag gtttggtgga      360

tgcacacaca catccagtat gggctggtga aagagttcac gaatttgcaa tgaagttggc      420

aggagccacc tacatggaaa ttcaccaggc cggaggaggg atccacttta ccgtggagcg      480

cacgcgccaa gccacagagg aggagctgtt ccgctccttg cagcaacggc tccagtgcat      540

gatgagggct ggcaccacgc tggtggagtg caagagtgga tatggcctcg acctggagac      600

cgagctcaag atgctgcgcg tgattgagcg cgcccggcgg gagctggaca tcggcatctc      660

ggctacctac tgcggggctc attcagtgcc taaaggaaaa actgctactg aagctgctga      720

tgacatcatc aataaccacc tcccaaagct gaaggaactt ggcagaaatg gggaaataca      780

cgtggacaat atagacgtat tttgtgagaa aggtgtcttt gatctcgatt ccaccagaag      840

gattcttcaa cgtggaaaag atatagggtt acagattaac ttccatgggg atgaactcca      900

cccgatgaag gctgctgagc ttggggctga actgggagcg caggcaatca gccacctgga      960

agaagtgagt gatgaaggca tcgttgccat ggcaacggcc aggtgctctg ccatccttct     1020

gcccaccaca gcctacatgc tgagactgaa acaacctcga gccaggaaga tgttagatga     1080

aggagtaata gttgctctgg gaagtgattt caaccccaat gcatattgct tttcaatgcc     1140

aatggtcatg catctggcct gtgtaaacat gagaatgtcc atgcctgagg ccttggccgc     1200

tgccaccatc aatgcagctt atgcactggg aaagtctcac acacacggat cgttggaagt     1260

tggcaaacag ggagatctca ttatcatcaa ttcatcccga tgggagcatt tgatttacca     1320

gttcggaggc catcatgaat taattgaata tgttatagct aaaggaaaac tcatctataa     1380

aacatgatag atttgaaaag agaagacttt ttgactatat gaaataagtc aatatagtta     1440

tattaaaagt taaaacacct taatatttac aagaattata tcacttaaac ctaaatgtac     1500

ttcaatgtct ttttaagtca ctcaaaaaac ccaagggata gatttatttt catttaacac     1560

atgcatttga catataaaca ggtaaaccta ttgtgattaa aatcacaaaa catccaatta     1620

gttcacaaat attggttaca aatattctgt agattaatat ggtggggtat cacaaaaatg     1680

cctttgtggg gaaaagtagg cttggcttaa aatttccatt ttgtgtctgt atttcacatc     1740

tcagttttta aactatattt agtgaacatt gagggatcga aagaaatcta agtgatacgc     1800

cccaatgaag ctaaaatata gccttctgtt aagcaaatag tatttccttt ccccaagtag     1860

ttcattttct agatgcttgt caaatgaatt aatgtcctct gatgaagagt gtccttccgt     1920

ttctaaggtc ttctcaatct cagcaataga gcttcccagc agcgttcaag acacatcatt     1980

tatacacagg cacaggggcc ttcctgaaat gggtgcattt ttaccaacta caatcatgta     2040

atttttttgg aaatttttta aaattttcga ttctttacat tacaattggg tgaaacacat     2100

tttacagctc tcaataaatg tttgctgtcg ctctta                               2136


<210> 474
<211> 5909
<212> DNA
<213> Homo sapiens

<400> 474
ggcgctcagc gcaggcaggt ccccctgctg ccgggtccca tttgttgccg gctctgactc       60

ggggcggccg cggcgcgcgg agctccgggg agtcaggcgg agcagccgcg cagccacgac      120

ggagcagcag cgggactggc cgccccgcgc ccccttcgcc gccgtgccct tccccggcgc      180

gctcaccccg ttctcgggat gggattgtag cggcggcgcg gactcggcgg ggatcgcggc      240

ggaggcggcg gcgtcggcgg cggcgtcggc ggccgagcgg ggctccatgt tttcccctgg      300

ccaggaggaa cactgcgccc ccaataagga gccagtgaaa tacggggagc tggtggtgct      360

cgggtacaat ggtgctttac ccaatggaga tagaggacgg aggaaaagta gatttgccct      420

ctacaagcgg cccaaggcaa atggtgtcaa acccagcacc gtccatgtga tatccacgcc      480

ccaggcatcc aaggctatca gctgcaaagg tcaacacagt atatcctaca ctttgtcaag      540

gaatcagact gtggtggtgg agtacacaca tgataaggat acggatatgt ttcaggtggg      600

cagatcaaca gaaagcccta tcgacttcgt tgtcacagac acgatttctg gcagccagaa      660

cacggacgaa gcccagatca cacagagcac catatccagg ttcgcctgca ggatcgtgtg      720

cgacaggaat gaaccttaca cagcacggat attcgccgcc ggatttgact cttccaaaaa      780

catatttctt ggagaaaagg cagcaaagtg gaaaaacccc gacggccaca tggatgggct      840

cactactaat ggcgtcctgg tgatgcatcc acgagggggc ttcaccgagg agtcccagcc      900

cggggtctgg cgcgagatct ctgtctgtgg agatgtgtac accttgcgag aaaccaggtc      960

ggcccagcaa cgaggaaagc tggtggaaag tgagaccaac gtcctgcagg acggctccct     1020

cattgacctg tgtggggcca ctctcctctg gagaacagca gatgggcttt ttcatactcc     1080

aactcagaag cacatagaag ccctccggca ggagattaac gccgcccggc ctcagtgtcc     1140

tgtggggctc aacaccctgg ccttccccag catcaacagg aaagaggtgg tggaggagaa     1200

gcagccctgg gcatatctca gttgtggcca cgtgcacggg taccacaact ggggccatcg     1260

gagtgacacg gaggccaacg agagggagtg tcccatgtgc aggactgtgg gcccctatgt     1320

gcctctctgg cttggctgtg aggcaggatt ttatgtagac gcaggaccgc caactcatgc     1380

tttcactccc tgtggacacg tgtgctcgga gaagtctgca aaatactggt ctcagatccc     1440

gttgcctcat ggaactcatg catttcacgc tgcttgccct ttctgtgcta cacagctggt     1500

tggggagcaa aactgcatca aattaatttt ccaaggtcca attgactgac gcccttgaca     1560

gccatctacg actttattaa caggttactg tgaagatttt gccactaact ctagatttta     1620

cctttttgta atgctgttta tcagaggagg gtgacagggg ctggaaataa agagagggga     1680

catggtgatg aaacatggca ggagtgtaac agataccagt ggtgtgttgc atgctcaaaa     1740

cagcagcgtc gtcattgaag tctgcttgat taaaccataa tatctttgta ataattggat     1800

ttaaaatgct atgcttctat ttttaacctt gggtttttaa ccaagttttt ttttttttgt     1860

aatcttggac aagactttaa atcatatttt acagatgtag aagaaattta ttcaaaagtg     1920

tgggctcatg aagttcactt cagtgcagtg tggtgtaggt gttacgcgaa gggcgcacag     1980

tgtctagaaa tacttgatcg tggctcaaac ctgaccagac agcagagggg cggctctgta     2040

cagtgtgact ggtggacaga tggccttagg cacaggtggt tttgaaatct ggggcttttt     2100

ctgatttatt tttctgactt gttgggggag agaatattca taacttgtgg gctttttttt     2160

tttttaactt cagtggaatt tactttagat attcattcat caaatacatg ggacttcaca     2220

aacaattttc cataactttt tagcctgtct tttgttattt ctgcctaata tgatttgccc     2280

cgatactcat cttgcacggc cagaactgtt tggttgatta aaatacatca gctcttaaaa     2340

actcattaac tgagggtaat tacagtagta gacatggtct gggtactata ctaccatgtt     2400

tatttgctga ctgaattaag atttaagaat gattaaaaat aagcttttac tttttaaaac     2460

cacttgaggt ttcataaagc ttggggtttt tttttttcct ttgttaagaa agccaaccaa     2520

tcacaatgat atagtcattg ttgtgcactc ccttttcacc atctgtcacc ttcccttgca     2580

gcttaaggag cccagtaagt tttgaaaatg tttgcgaatc aaactaaatt taagtgggat     2640

gattagatat acacaacacc aagtggtaca tctgcagaga taattcaaaa ttcctgcttt     2700

tgagagagca aatgagtgtt gctgaggaat aattaaatga gaatttcata ggagctccac     2760

cattcctgtt actttcattt cattttgatt aataattctt ggatgcttgg catcgatcgt     2820

atcactgctc ctagaaggta aagatccttt aggacatgag actggtagaa gctggctgag     2880

ataaaataag tatttattta aactaatgtt ctcttaattt gaccattgca gatttgggtg     2940

actttttttt aacctttgta catatacgta atttatatga ttctaatgta ctatatccat     3000

acttgaattg gttttttcgt attttgccta ctggcaaata ttttgcctat tttcagtcgt     3060

tctaacctat ttgaatacgc ttttccttaa agtgatacga taatattact cttgattgct     3120

gctgcttaat ttgatgtaat atgtttaaag ttcagcctct cagttttaat atagctttat     3180

ttttcagtgg agatcattgt ttaggatgag acatttttgg ttttggtttt gtttgggtaa     3240

attttaaatg gtgtgaaaat cgatgacaac agtcctctta cagatagctt gctgtattct     3300

gtatagctta ctctacctgc agacagaaaa tgaaagaaaa aaatggactt gcctagaata     3360

atatattgaa tgccttttga tttagccaga gtctctgatg attagctttc actgatagag     3420

tatgtctttt cagcctgtaa ttctttgggc cccaaagaat gacaaaggag gcactcgttc     3480

tcttttcttg ctgtatgcct agaaagtggt tgaaggattc ttgatgccct aaaaccatct     3540

tgtaagctaa atggtcttgc atccagaaag gccagatttt acctaccaag aaaaaaagat     3600

atttttccag agagttaggt atatcataat tttccatttc aagtcctgtt tataagtcta     3660

gtcattctgc aacgtgacat atcccccaaa atgaagttac cttccaagtt ggacacgtcc     3720

cgtagttggg catatgtcta actaaaagtt tctgactttt agtaaattca gcttaaatat     3780

aagttgaaat ttgggaaata atttccaagc tcttggaagg ggtaacagtg aaccgccctc     3840

catgggctcc acatcttttc ctttggcttc caaagtcagg tcccgcccac cctgcctaag     3900

gaactgcaga gaggtggcaa atcagcaaaa aggacaccag gctcttcttg gccacttgta     3960

ggaagatccc tttacaattt tgactaagga gatttttttt ttcacagttg agttagtttg     4020

tgaaaataaa gaactctgta gctcaccaag gtggagaaac gcaattcaga aaagtaattt     4080

ctccaaggtc acttcttttt ttatgtcttg ccatcacttt aaaggactag ccccactccc     4140

ccatgtgtat acacaaggaa attgcagacc aattagttgt cttggcctga ctctaatgcc     4200

ttttgcaagt agctttccag aagtaaaagt cccagtgatg tattcccata gaaatatttt     4260

tcagttgttt atgtcgttta ctacaaaaaa aaagattcag agtggatgga gtacaactct     4320

gagtattttt ctagtccgga attttttatt aataatcggt gctgccgggt catgcatgct     4380

gcaactctca acatttccct tatttggttc agcttttagc aaaaagggct acagttcacc     4440

ctgcagagta ttaaggtttc tggatttttt tctcccaact gtggcccaaa agaattaaaa     4500

tctgttaata taaatagaga acatatttat cattcctcga tagttaatta tagactttgg     4560

tacctttgtg cctcagggaa gccacgtgat ataactggtt atagaatttc agggttaggg     4620

tttaaagaaa ggagaaagcc attggaaaaa tgatgggctc cattaaggag actaatgaat     4680

ctggatgcag aaatatgtca gaaactggca taaacatgat tgtagtagaa tttattttcc     4740

agtaccaata gggaaattat tttaagttat tacatttact gtattgggaa acttgaggag     4800

aactctttag ttcataaagc ttcaatgtct tttttttttt tttcatggaa aaactcaaac     4860

ctctgttatt tgggagctca gtattgtgtg gacacttacg agagttttct gcttaattga     4920

agtgtaatat aggttgtaga attgttacct gcagttctat ggttttgttt cacttctttt     4980

cttttttaaa gccattctgt tctttggatg tgcttgaaag ggtgtgtgat tacaccattg     5040

ttaatgctgg gtaaaaacta tcttcttgca gccttgcctc ataacagtgg aatttctgat     5100

agacaaacca caggactttg attttaagcc aaatccatct ccatcccttt actgtcaatc     5160

ttctgtccca gtagtttagc ctttgtggct taggttatga tgcgcctcct tctgtgcgac     5220

caatgagacg acttcagcat ctttttaaaa taatctaagc atcattgaag cagtaacaca     5280

aaaaaaaggt tcagtatttt ctttttagta taacttacat cctttcaaat aagtctttgc     5340

cctcatgaag aatccctaga ggaagataag gaaaataagt attttccagt tttgcttgac     5400

agtttctaaa caaacaaaaa taaactcaat gaaaggaaag atgtttcttt ttagctgaga     5460

tgacagattg cttctctgta ttaaatagtc tagaagttaa ggggatggtc acatttacca     5520

tgtattgtgt tattagcagt taaattttat gaatatgttt gtaaaattgt tgttttatat     5580

ttcatgtcaa attgaaaagt ttatttcttc actattgtac ctgtggaaat acaagccatt     5640

ttacaggaaa aaatcttcaa aaactattaa atggatatca gcctgtttgt gagccattgt     5700

cttcagattc tgtggttgtc actgagttca ttaggacatt tagtaggttg atacgagtag     5760

aactgatttt tttcacttct ctaacttcca agttaatctc cagctgttga gtttattaat     5820

tgttttatat tctgcacaat acatatttaa accttgattc tgaaaatccc ctacattttt     5880

taattaaaga aatttccttg gtgcctata                                       5909


<210> 475
<211> 2559
<212> DNA
<213> Homo sapiens

<400> 475
agtgacgcgc gagcggctcc cgcgactgtg gctcccgaag ctgcttcggg ccccagcggt       60

gaggaagaag actctcaacc agggtgactt ctaggcgtcc tcccggagct accggggaca      120

ctggcgttat tgcccgcaac actgagatag ggaatgctcg agaaacagaa gcaggagtat      180

tttatacaga aatcttgtga aaccactgcc caaccagagc aatgattgtt caaagagtgg      240

tattgaattc tcgacctgga aaaaatggta atccagtggc agagaatttc cgaatggaag      300

aagtctattt accagataat attaatgaag gacaagtaca agttagaact ctttatcttt      360

ctgtggatcc ttacatgcgt tgtagaatga atgaagacac tggcactgat tatataacac      420

cttggcagct atctcaagtc gttgatggag gaggtattgg aattatagaa gaaagcaaac      480

acacaaattt gactaaaggc gattttgtga cttctttcta ttggccctgg caaaccaagg      540

ttattctgga tggaaatagc cttgaaaagg tagacccaca acttgtggat ggacaccttt      600

catattttct tggagctata ggtatgcctg gtttgacttc cttgattggg atacaggaaa      660

aaggtcatat aactgctgga tctaataaga caatggttgt cagtggggcc gcaggtgcct      720

gtggatctgt ggctgggcag attggccatt tcttaggttg ttccagagtg gtgggaattt      780

gtggaacaca tgagaaatgc atcctcttga cctcagaact gggctttgat gctgcaatta      840

attataaaaa agacaatgtg gcagaacagc tccgtgaatc atgcccagct ggagtggatg      900

tttattttga caatgttggt ggtaacatca gtgatacagt gataagtcag atgaatgaga      960

acagccacat catcctgtgt ggtcaaattt ctcagtacaa caaagatgtg ccttatcctc     1020

ccccgctatc ccctgctata gaggcaatcc agaaagaaag aaacatcaca agggaaagat     1080

ttctggtatt aaattataaa gacaaatttg agcctggcat tctacagctg agtcagtggt     1140

ttaaagaagg aaagctaaag attaaagaga cggtaataaa tgggttggaa aacatgggag     1200

ctgcattcca gtccatgatg acaggaggta acattggaaa gcagatagtt tgcatttcag     1260

aagaaatctc tttgtaattg ctgtaaatgt catcaaggca atcatagatt tcttttccat     1320

tttgcatatt ttcaaagata tgttaaaaaa tccttagact atacatagct cttgatttaa     1380

atgtgatcat aggtgttatt tttagttgca tagggtattt gatacaatca ttaatggatc     1440

atacacaata ggtttttaaa aattaataac ttttagtaat tacttttatt aatttaaaat     1500

agaacgcttg agaggcactt tgtaaagatt tgttaaactg gaaacgtttt acatgatctg     1560

atacaaccat taatgaatca tacacaatag gttttttaaa attaatatta ataactttta     1620

ttaatttaaa atagaatgct taaaataaaa tagaatgctt gagaggcact gagtaaagat     1680

ttgttgaact ggaaatgttt tacatgattc ttaaactgaa acttggtgta aaaatagaat     1740

tgagatggcc tttttttcac attgtagact gaaaagagac ttaatggtat gatgtgtaca     1800

tagggactgg gggcaggatt gggggtttcg gagcttgtgt aacagttttt gggataggag     1860

accagcggtt ttgggttggg attagtatgg gaagataaat aacttaggtt ggttaagttg     1920

acaagattta ctccagagga tcatctcttt gtatttgcca aataatttac tgtatagcct     1980

aaaaactcca tatatattga gaaaagcata tgtttatttt aggttagcag gcacatactg     2040

tcaagttgta aagattgaga gggcaaacag atgtaaacat cacttgtagg tgattaaaaa     2100

gattgacagc cgggcctgat gtctcaagcc tgtaatccta gcactttggg aggcagaggc     2160

gggcagatca cttgaggtca ggagttcaag accagcctgg ccaacacggt gaaaccccat     2220

ctctctaaaa atacaaaaat tagctgggcg tggtggcaca cgcctgtaat cccagctact     2280

caggaggctg aggctggaga atcatttgaa cctgggaggg ggaggttgcc gtgagctgag     2340

cttgcaccat tgcactccag cctgggcgac aagagtgaaa ttccatctca aaaaacaaaa     2400

acagattgac aacaaagaca gtttcagaaa atgacaggac tgggcaaatt aacaaatgtt     2460

tgtaaacatg aatgttcagg aactactgat gtacctcaaa agtttgtttt attaattgta     2520

ctcaaccctc gcagaacagt aaaactgaag attattgtt                            2559


<210> 476
<211> 3300
<212> DNA
<213> Homo sapiens

<400> 476
aagcgagtgg cgctttcacc ttagcaacca gcgcggctcc caccatggct gaagaagagg       60

aaactgctgc tctcacggag aaggttatcc ggacccagag ggtgtttata aacctgttgg      120

attcctacag cagcggaaac atcgggaagt ttctatctaa ctgtgtagtt ggggcttcgc      180

ttgaagaaat tacagaggaa gaggaagagg aagatgaaaa taagtcagct atgctggaag      240

cttcctcaac caaagtgaag gaaggcacat tccagattgt gggcacgctg tccaagcctg      300

acagcccgcg gcctgacttt gcggtggaga cgtactctgc catctctcga gaagaccttc      360

tcatgcgcct gctggagtgt gatgttatta tttataacat cactgagagc tcacagcaaa      420

tggaggaagc catctgggca gtctctgcac tcagtgaaga agtcagccac tttgaaaagc      480

gaaagctatt tattttactg tcgacggtga tgacttgggc gcgctccaaa gccctggacc      540

ccgaggattc tgaggttcca ttcactgaag aagattatcg aagaagaaag tctcatccta      600

attttctgga ccacataaat gctgaaaaaa tggttctcaa atttggaaaa aaggccagaa      660

aatttgcagc atacgtagtt gctgctggac tccagtatgg agcggaagga ggcatgttac      720

acacattttt taagatggct tggttgggcg agattcctgc attaccagtt tttggcgatg      780

gaacaaatgt aattccaaca atccatgttc ttgatctagc aggagtgata caaaacgtca      840

tagatcacgt gccaaagcct cactacctgg ttgctgtgga tgagtctgtt cataccctgg      900

aagacatagt caagtgtatc agtaaaaata ctggccctgg gaaaatccag aaaataccca      960

gagaaaatgc atacctaacc aaggacttaa cgcaagattg tcttgaccat ttactggtca     1020

acttaagaat ggaagcgctc tttgtgaagg agaattttaa tattcgatgg gctgcccaaa     1080

caggatttgt ggaaaatatc aacactatcc tcaaggagta caagcaaagc agaggattga     1140

tgccaatcaa gatctgcatt cttggtcccc ctgctgtggg aaaatccagt attgctaaag     1200

aattggccaa ctactacaaa ctgcatcaca tccaactgaa ggatgtcatt tctgaagcca     1260

tagcaaaact ggaggcgatt gttgccccta acgatgtagg ggaaggagaa gaagaagtcg     1320

aagaggaaga ggaggaggag aatgtggaag atgcacagga gctcctagat ggcatcaagg     1380

agagcatgga gcagaatgca ggtcaactag acgatcaata tataattaga tttatgaaag     1440

aaaagctaaa atcaatgcct tgcaggaatc aaggttatat tttggatgga ttcccaaaga     1500

cctatgatca agcaaaagac ctgttcaatc aggaagatga ggaggaggaa gatgatgtca     1560

gaggcagaat gtttcccttt gataaattaa ttatacctga attcgtttgt gcactggatg     1620

cttcggatga gtttctgaag gagcgtgtga taaaccttcc tgagagcatc gtggcgggga     1680

cccactacag ccaagaccga ttcctccggg ctctgagcaa ctaccgggac atcaatatcg     1740

acgatgagac tgtcttcaac tattttgatg aacttgaaat tcacccgata catattgatg     1800

taggaaaact tgaagatgct cagaatagac ttgctatcaa acagctcatc aaagagattg     1860

gggagcctcg aaattatggt ttaacagacg aagaaaaggc agaagaggag cggaaggctg     1920

cggaggagcg gctggccagg gaggctgctg aggaagcaga acgcgagcac caggaggccg     1980

tggagatggc agagaagata gctcgctggg aggagtggaa taaacgactg gaggaagtga     2040

aaagagaaga aagagaatta ctggaggctc agtcaattcc cctgagaaac tatttaatga     2100

cctatgtgat gccaactctt attcagggcc tgaatgaatg ttgcaacgtc cgacccgaag     2160

accctgttga ttttctggca gaatatctct tcaagaacaa tcctgaagca cagtgaaact     2220

tgaaagatct ggtattatct acctttacag aaccacagat cacttattat actttgaaaa     2280

attgctttga aaaatgcttt tccagttctt agaaaattct ttttttgtag acaaatattc     2340

tataaactag aatctctatt aaaagctata tgacatgact atgtcattaa aactatattt     2400

gaaatgtaaa ttgataaaga catttgtgca tagctcatga gacaaatact gatttaatat     2460

tttattcttt agtcagatct aaatataccg cttctgtaca ctaatgttta taggtattta     2520

tagcatgaag aaaatcagac tatatattgt agactatgta ttattctaac atgtaggcta     2580

atttacatga cttgttatcg ccccaataac aatgttatta gaaatggaaa taaattgaag     2640

tgatttatgc ctgttgactc acagtaaatc agacaagatt ggtgcctgta aggtggcttt     2700

tttttttttt ttttttaaat gaagcaatgg ttagggaaag gttgctttga gttcagggtc     2760

aggatcccag acaatgaatc ggagagaact gtaaaccttt aggcggagaa atctgcataa     2820

caggataatt ccaatctttg tgataagtga gaagttgcta aatattttca acacacttta     2880

taacataggc ataagttatc aatcctatag tcttttccag ttctaaaaat cccataagat     2940

tcctagaatt accctaaatg agaaattagt ttaggtttaa tggcatatgt attttatctc     3000

tttaaataat gtaacctaat ataactgccc gactttttat ttgtgctaaa atacatgtaa     3060

cataaaattg accactgtaa ccattttaaa gtgtataatt cagtggcact aagttcattc     3120

acaatgatct gcagccacca ctatctagtc cagaactttc tcatcacccc aaatggaaac     3180

ccagcaccta ttaggcagtc acgctccatt attccctccc cccagttcca ggcaaccacg     3240

aatctgcttt ctgtctctat ggatttacct attataaata aaaccatata atgggtggtc     3300


<210> 477
<211> 3118
<212> DNA
<213> Homo sapiens

<400> 477
ggccgaggag gaagtggcgg cggcggcggc gggactgcgc gccccagctc cgatccccgt       60

tccgcgtccc cgccgccggg aggaggtgcc cactcgctcg cggcgcgcgc cggccgccag      120

actcggcctg tgggcgattt cctccggacc caggctcccc gcccgaggag gaagatgcag      180

acctttctga aagggaagag agttggctac tggctgagcg agaagaaaat caagaagctg      240

aatttccagg ccttcgccga gctgtgcagg aagcgaggga tggaggttgt gcagctgaac      300

cttagccggc cgatcgagga gcagggcccc ctggacgtca tcatccacaa gctgactgac      360

gtcatccttg aagccgacca gaatgatagc cagtccctgg agctggtgca caggttccag      420

gagtacatcg atgcccaccc tgagaccatc gtcctggacc cgctccctgc catcagaacc      480

ctgcttgacc gctccaagtc ctatgagctc atccggaaga ttgaggccta catggaagac      540

gacaggatct gctcgccacc cttcatggag ctcacgagcc tgtgcgggga tgacaccatg      600

cggctgctgg agaagaacgg cttgactttc ccattcattt gcaaaaccag agtggctcat      660

ggcaccaact ctcacgagat ggctatcgtg ttcaaccagg agggcctgaa cgccatccag      720

ccaccctgcg tggtccagaa tttcatcaac cacaacgccg tcctgtacaa ggtgttcgtg      780

gttggcgagt cctacaccgt ggtccagagg ccctcactca agaacttctc cgcaggcaca      840

tcagaccgtg agtccatctt cttcaacagc cacaacgtgt caaagccgga gtcgtcatcg      900

gtcctgacgg agctggacaa gatcgagggc gtgttcgagc ggccgagcga cgaggtcatc      960

cgggagctct cccgggccct gcggcaggca ctgggcgtgt cactcttcgg catcgacatc     1020

atcatcaaca accagacagg gcagcacgcc gtcattgaca tcaatgcctt cccaggctac     1080

gagggcgtga gcgagttctt cacagacctc ctgaaccaca tcgccactgt cctgcagggc     1140

cagagcacag ccatggcagc cacaggggac gtggccctgc tgaggcacag caagcttctg     1200

gccgagccgg cgggcggcct ggtgggcgag cggacatgca gcgccagccc cggctgctgc     1260

ggcagcatga tgggccagga cgcgccctgg aaggctgagg ccgacgcggg cggcaccgcc     1320

aagctgccgc accagagact cggctgcaac gccggcgtgt cgcccagctt ccagcagcat     1380

tgtgtggcct ccctggccac caaggcctcc tcccagtagc cacggagccg ggacccagag     1440

gggcagcgca gggcgcagag cacacccgct gggccagcag ctcccaacgg cgatgctact     1500

actaagaatc cccagtgatc tgattcttct gttttttaat ttttaacctg attctctgat     1560

gtcatgatct aaatgagggg tagtggggga tggaagagag taccaggtgg tccaccgttg     1620

gggagtgggg ccgtccgcct gctctctact gtgcagacct cctaactgag tttacacacg     1680

cttgtgtttg caacactagg tctggatggg aggtgagggg tgtgcgtatg gctgccatgc     1740

cagtgtctgt gcacatccct gtctgttggt ctccatggcc actgtggacc gggacccttg     1800

ggggaagcct gcccatgtcg ggctgtggga ggctgatcgg tgcatgtgag agtggcttcc     1860

cttctgcctg actccccact ccctgacctg ccccttcctt gtttttcctc ctactggtct     1920

ccaccaaggc tttgttagcc cccaccctgc ctggtgtgca gctaacccct ccctccccac     1980

agccagagga ggccacagac ccctcagggg agttccgcgc tggggtctgg gctgtgctcc     2040

ctcactaaag ggaaggaaag gaagctgggc gtcctctggg ccccccaaca cacgtcccat     2100

ttagccctgc acagcggtct ccttccccta agccagcact gctgctccct ggagcccggg     2160

aaggaggctg cctggctgga ggcccgagcc gatggcgcct gtgctgagga tttgtgctgt     2220

gatttgggca aatcattcca ggtctttggg cctccacccc cttgtctcta gtggacattt     2280

gagatcagag agcaccacag ggctggcttt gtgccctaac ccctgggatg cagcctgcct     2340

ttccataaag tcacctaggt gaggataggc gcgggagcct cggcatgaca ccatggagat     2400

cggggccctc ttcccagtgg gttcactcct tttcacacct gctgggtccc tcctcaccca     2460

gcaggcctgg tccacctctc attgcaagcc ccaagcactg agccagcagg tgccagggag     2520

ccacccgccc cccatcgctt ctgcacacct cagactcacc ccatcacctt ggcagcaaag     2580

cactggctct gccgtctgac ccctgatcca ggcagccccc tctgcagaga aaagggttgg     2640

ggagaagcct ctgcagtcct ggaagatgtg gggtgctggg tgagaggcat cagcccccac     2700

aagtatgttt ttgtgtctta agatagcagt ttactttgaa aaagtgaaaa aggcttccgg     2760

gctgtcctct gcccagtgag atggaggacg ctagagaaag tgctgagtgt cccgagagag     2820

gcccccgagc cagtgcatgg aggtccttcg gcctggctca gctgggctgc aggatgccca     2880

ctttgaggag ggaggcacag ggcttgggcg aggggcagag gccatcagaa ctgcccggct     2940

tttttggaaa ctgaggaccc aacaactaac cacgtttaca cgacttgagt tttgaacccc     3000

gattaatgtc tgtacgtcac ctttcctagt tctgaccctg agccctgggg aacaggaaag     3060

cgtggctggc ctcttgcact gctttgtctc caaaataaac tactgaaatc aaaccgca       3118


<210> 478
<211> 1067
<212> DNA
<213> Homo sapiens

<400> 478
agggaaggat tctgggagac ggaggaggag acgccagcat ttcgccccct gcacctccag       60

cgggctgcgg tccgctcccg gcctcactcg agcaggcccc gccctcccag aggcagttag      120

tccaagtcac gtgatcgtcg actcagctga ccctgcggga ccggaaaaag aaattcccgg      180

gccctggctt cttggcgcga tgaggttccg gttctgtggt gatctggact gtcccgactg      240

ggtcctggca gaaatcagca cgctggccaa gatgtcctct gtgaagttgc ggctgctctg      300

cagccaggta ctaaaggagc tgctgggaca ggggattgat tatgagaaga tcctgaagct      360

cacggctgac gccaagtttg agtcaggcga tgtgaaggcc acagtggcag tgctgagttt      420

catcctctcc agtgcggcca agcacagtgt cgatggcgaa tccttgtcca gtgaactgca      480

gcagctgggg ctgcccaaag agcacgcggc cagcctgtgc cgctgttatg aggagaagca      540

aagccccttg cagaagcact tgcgggtctg cagcctacgc atgaataggt tggcaggtgt      600

gggctggcgg gtggactaca ccctgagctc cagcctgctg caatccgtgg aagagcccat      660

ggtgcacctg cggctggagg tggcagctgc cccagggacc ccagcccagc ctgttgccat      720

gtccctctca gcagacaagt tccaggtcct cctggcagaa ctgaagcagg cccagaccct      780

gatgagctcc ctgggctgag gagaagggtg ttccaggcct gtgtggagcc gccctgcccg      840

tatggagtca cgccctctga actgctcttc gggaggcagc cctggttcta ggatgctgag      900

gccctggccc ggactctggc ctcccagatc cccagctgcc tcacttctct cttgagaact      960

tggctcaggg ctcctgagga cctttcccag cattaccttc ccttcccttg aaaggcaatt     1020

gttggctgtt ttcataagca ggaaaaataa acagaagtat aaaggaa                   1067


<210> 479
<211> 2134
<212> DNA
<213> Homo sapiens

<400> 479
ggcggctagc ggcgaggccc cttcctgacc ttcagggatc ggccaccatg tcccaccgga       60

agttttccgc ccctcggcac ggacacctgg gcttcctgcc ccataagagg agccaccggc      120

accggggcaa ggtgaagacg tggccgcggg atgaccccag ccagcccgtg cacctcacgg      180

ccttcctggg ctacaaggcg ggcatgaccc acaccctgcg ggaggtgcac cggccggggc      240

tcaaaatttc caaacgggag gaggtggagg cggtgacaat tgtagaaacg ccgcccctag      300

tggtggtggg cgtggtgggc tacgtggcca cccctcgagg tctccggagc ttcaagacca      360

tctttgcaga acacctcagt gatgagtgcc ggcgccgatt ctacaaggac tggcacaaga      420

gcaagaagaa agccttcacc aaggcctgca agaggtggcg ggacacagac gggaaaaagc      480

agctacagaa ggacttcgcc gccatgaaga agtactgcaa ggtcattcgg gtcattgtcc      540

acactcagat gaaactgctg cccttccggc agaagaaggc ccacatcatg gagatccagc      600

tgaacggtgg cacggtggcc gagaaggtgg cctgggccca ggcccggctg gagaagcagg      660

tgcccgtgca cagcgtgttc agccagagtg aggtcattga tgtcattgct gtcaccaagg      720

gtcgaggcgt caaaggggtc acaagccgct ggcataccaa gaagctgccg cggaagaccc      780

ataagggcct gcgcaaggtg gcctgcattg gcgcctggca ccccgcccgc gtgggctgct      840

ccattgctcg ggccgggcag aagggctatc accaccgcac ggagctcaac aagaagatct      900

tccgcatcgg caggggcccg cacatggagg acgggaagct ggtgaagaac aatgcatcca      960

ccagctacga cgtgactgcc aagtccatca caccgctggg tggcttcccc cactacgggg     1020

aagtgaacaa cgacttcgtc atgctgaagg gttgtattgc tggtaccaag aagcgggtca     1080

ttacgctgag aaagtccctc ctggtgcatc acagtcgcca agccgtggag aatattgagc     1140

tcaagttcat tgacaccacc tccaagttcg gccatggccg cttccagaca gcccaagaga     1200

agagggcctt catgggcccc caaaagaagc atctggagaa ggaaacgccg gagacctcgg     1260

gagacttgta ggctgtgtgg ggtggatgaa ccctgaagcg caccgcactg tctgccccaa     1320

tgtctaacaa aggccggagg cgactcttcc tgcgaggtct cagagcgctg tgtaaccgcc     1380

caaggggttc accttgcctg ctgcctagac aaagccgatt cattaagaca ggggaattgc     1440

aatagagaaa gagtaattca cacagagctg gctgtgcggg agaccggagt tttatgtttt     1500

attattactc aaatcgatct ctttgagcat ttgcggagca gaggtttttt tttttttttt     1560

ttttgagaga gtcttgatct tgtcgcccag gctgctggag tgccggggag cagagttttt     1620

aaggataact tggcgggtgg ggagagccag tgagccagga gagccgattg gtcagggagg     1680

aaatcacagg gagtcagctg tcttcttgcg ctgagtcagc tcctgggtgg tggccacaag     1740

atcagatgag ccagtttatc aatctggttg gtgccagcag atccatcaag ttgcagggtc     1800

ggcaaaatat ctcaagcact gatcttaggg gcagcttagg gagggtcaga atcttgtagc     1860

ctccagatgc acgactccta aaccataatt cccaatattg tggctaatgt tagtcctaaa     1920

aatgcaatct agtccccagg caaggaggtg gtctgctttg ggaaagggct gttactgtct     1980

ttgttttaaa ctataaactg gctgggcgcg gtggctcacg cctgtaatcc cagcactttg     2040

ggaggccaag atgggcggat cacctgaggt cgggagttca agaccagcct ggccaacatc     2100

gagaaacctc gtctctatta aaaatacaaa atta                                 2134


<210> 480
<211> 8473
<212> DNA
<213> Homo sapiens

<400> 480
ggagggagag gggttgagtc aagatggcgg ccaaggtggc gaagcagcag ccgcggcggc       60

ggcggcggct ggagtgagcg tccgactcgc cgcgccgaac gaggtcccgg tgtagggccg      120

cgcgccgtgg ccgcgtccca ctcctcaggc cggggcgcac gtcggctccc acgcttagcc      180

agctcccggt ggtttcctag aaacatgatt gtttattggc attgatctca cagtctggtg      240

aggacttctt tactgataat gtcaagttca ggttatcctc ccaaccaagg agcattcagc      300

acagaacaaa gtcgttatcc tcctcactct gtccagtata catttcccaa cacccgccac      360

cagcaggagt tcgcagtccc tgattatcgt tcctctcatc ttgaagtgag tcaggcatca      420

cagcttttgc agcaacagca gcagcaacag cttcgaaggc gaccttcctt gctttcagaa      480

tttcacccag gttctgacag gcctcaagaa aggagaacta gttatgaacc gtttcatcca      540

ggcccatccc cagtggatca tgattcactg gaatcgaagc gaccacgtct ggaacaggtt      600

tctgattctc attttcagcg tgtcagtgct gcggttttgc ctttagtgca cccgctgcca      660

gaagggctga gggcttctgc agatgctaag aaggatccag cattcggagg caaacatgaa      720

gctccatcct ctccaatttc ggggcaacca tgtggagatg atcaaaatgc ttcaccttca      780

aaactctcaa aggaagagtt aatacagagt atggatcgtg tagatcgaga aattgcaaaa      840

gtagaacagc agatccttaa actgaaaaag aaacaacaac agcttgaaga agaggcagct      900

aaacctcctg agcctgagaa gcccgtgtcc cctcctcctg tggagcagaa acaccgcagt      960

attgtccaaa ttatttatga tgagaatcgg aaaaaagcag aagaagctca taaaattttt     1020

gaaggtcttg gcccaaaagt tgaactgcca ctgtataacc agccatcaga taccaaggtg     1080

taccatgaga acatcaagac aaaccaggtg atgaggaaaa aactcatttt attttttaaa     1140

agaagaaatc atgcaagaaa acaaagggaa caaaaaatct gccagcgtta tgatcagctc     1200

atggaggcat gggagaaaaa agtggacaga atagaaaata atcctcggag gaaagctaaa     1260

gaaagcaaaa caagggaata ctatgaaaag cagtttccag aaattcgaaa acaaagagaa     1320

cagcaagaaa gatttcagcg agttgggcag aggggagctg gtctttcagc caccattgct     1380

aggagtgagc atgagatttc tgaaattatt gatgggctct ctgagcagga gaataatgag     1440

aaacaaatgc ggcagctctc tgtgattcca cctatgatgt ttgatgcaga acaaagacga     1500

gtcaagttca ttaacatgaa tgggcttatg gaggacccta tgaaagtgta taaagatagg     1560

cagtttatga atgtttggac tgaccatgaa aaggagatct ttaaggacaa gtttatccag     1620

catccaaaaa actttggact aattgcatca tacttggaga ggaagagtgt tcctgattgt     1680

gttttgtatt actatttaac caagaaaaat gagaattata aagccctcgt cagaaggaat     1740

tatgggaaac gcagaggcag aaaccagcaa attgctcgac cctcgcaaga agaaaaagta     1800

gaagaaaaag aagaggataa agcagaaaaa acagaaaaaa aagaagaaga aaagaaagat     1860

gaagaggaaa aagatgaaaa agaagactcc aaagaaaata ccaaggaaaa ggacaagata     1920

gatggtacag cagaagaaac tgaggaaaga gagcaagcca caccccgggg gcgaaagact     1980

gccaacagtc agggccgccg taagggccgg atcaccaggt ccatgacaaa cgaagctgca     2040

gctgccagtg ctgcagccgc agcggctact gaagagcccc caccacctct gccaccgcca     2100

ccagaaccca tttctacaga gcctgtggag acctctcgat ggacagaaga agaaatggaa     2160

gttgctaaaa aaggtctagt agaacatggt cgtaactggg cagcaattgc taaaatggtg     2220

ggaacgaaaa gtgaagctca atgtaaaaac ttctatttta actataaaag gcgacacaat     2280

cttgacaacc tcttacagca gcataaacag aaaacttcac gaaaacctcg tgaagagcga     2340

gatgtgtctc aatgtgaaag tgtcgcttcc actgtttctg ctcaggagga tgaagatatt     2400

gaagcctcca atgaagaaga aaatccagaa gacagcgaag ttgaagctgt caagcccagc     2460

gaggacagtc ctgaaaatgc tacttctcga ggaaacacag aacctgcggt tgagcttgag     2520

cccaccacgg aaactgcacc cagtacatct ccctccttag cagttccaag tacaaaacca     2580

gctgaagatg aaagtgtgga gacccaggtg aatgacagca tcagtgctga gacagcagag     2640

cagatggatg tagatcagca ggagcacagt gctgaagagg gttctgtttg tgatccccca     2700

cccgctacca aagctgactc tgtggacgtt gaagtgaggg tgccagaaaa ccatgcatct     2760

aaagttgaag gtgataatac caaagaaaga gacttggata gagccagtga gaaggtggaa     2820

cctagagatg aagatttggt ggtagctcag caaataaatg cccaaaggcc cgagccccag     2880

tcagacaatg attccagtgc cacgtgcagc gctgatgagg atgtggatgg agagccagag     2940

aggcagagaa tgtttcctat ggactcaaag ccttcactgt taaaccccac tggatctata     3000

ctcgtctcat ctccgttaaa accaaatcca ctggatctgc cacagcttca gcatcgagct     3060

gctgttatcc caccaatggt atcctgcacc ccatgtaaca taccaattgg aaccccagtg     3120

agcggctatg ctctctacca gcgacacatt aaagcaatgc atgagtcagc actcctggag     3180

gagcagcggc agagacaaga acagatagat ttggaatgta gaagttctac aagtccatgt     3240

ggcacatcca agagtccaaa cagagagtgg gaagtccttc agcctgctcc acatcaagtg     3300

ataactaatc tccctgaagg cgttcggctt ccgacaactc gaccaaccag gccaccgccc     3360

cctctcatcc cgtcatccaa aaccacagtg gcttcagaaa aaccatcttt tataatggga     3420

ggctccatct cacagggaac accaggcact tatttgactt ctcataatca ggcttcctac     3480

actcaagaaa cacccaagcc gtcagtggga tctatctctc ttggactgcc acggcaacag     3540

gaatctgcca aatcagctac tttgccctac atcaagcagg aagaattttc tccccgaagc     3600

caaaactcac aacctgaggg tctgttggtc agggcccaac atgaaggtgt agtcagaggt     3660

accgcaggag ccatacaaga aggaagtata actcggggaa ctccaaccag caaaatttca     3720

gtggagagca ttccatccct acggggctct atcactcagg gcaccccggc tctgccccag     3780

actggcatac caacagaggc tttggtgaag gggtccattt cgagaatgcc cattgaagac     3840

agcagtcctg agaaaggcag agaggaagct gcatccaaag gccatgttat ttatgaaggc     3900

aaaagtggac atatcttgtc atatgataat attaagaatg cccgagaagg gactaggagt     3960

ccaagaacag ctcatgaaat cagtttaaag agaagctatg aatcagtgga aggaaatata     4020

aagcaaggga tgtcaatgag ggagtctcct gtatcagcac cgttagaggg gctgatatgc     4080

cgagcattac ccagggggag tcctcattct gacctcaaag aaaggactgt attgtctggc     4140

tccataatgc aggggacacc aagagcaaca actgaaagct ttgaagatgg ccttaaatat     4200

cccaaacaaa ttaaaaggga aagtcctccc atacgagcat ttgaaggtgc cattaccaaa     4260

ggaaaaccat atgatggcat caccaccatc aaagaaatgg ggcgttccat tcatgagatt     4320

ccaaggcaag atattttaac tcaggaaagt cggaaaactc cagaagtggt ccagagcaca     4380

cggccgataa ttgagggttc catttcccag ggcacaccaa taaagtttga caacaactca     4440

ggtcaatctg ccatcaaaca caatgtcaaa tccttaatca cggggcctag caaactatcc     4500

cgtggaatgc ctccgctgga aattgtgcca gagaacataa aagtggtaga acggggaaaa     4560

tatgaggatg tgaaagcagg cgagaccgtg cgttcccggc acacgtcagt ggtaagctct     4620

ggcccctccg ttcttaggtc cacactgcat gaagctccca aagcacaact gagccctggg     4680

atttatgatg acaccagtgc acggaggacc cctgtgagtt atcaaaacac catgtccaga     4740

ggctcaccca tgatgaacag aacttctgat gttacaattt cttctaacaa gtctaccaat     4800

catgaaagga aatcgacact gacccctacc cagagggaaa gtatcccagc gaagtctcca     4860

gtgcctgggg tggaccctgt cgtgagccac agtccgtttg atccccatca cagaggcagc     4920

actgcaggcg aggtttatcg gagccacctg cccacgcact tggatccagc catgcctttt     4980

cacagggctt tggatcctgc agcggctgct tacctgtttc agagacagct ttcaccaact     5040

ccaggttacc caagtcagta tcagctttac gcaatggaga acacaagaca gacaatctta     5100

aatgattaca ttacctcaca acagatgcaa gtgaacttgc gtccagatgt ggccagagga     5160

ctctccccaa gagagcagcc actgggtctc ccatacccag caacgagagg aatcattgac     5220

ctgaccaata tgcctccaac aattttagtg cctcatccag ggggaacaag cactcctccc     5280

atggacagaa tcacttatat tcctggtaca cagattactt tccctcccag gccgtacaac     5340

tctgcttcca tgtctccagg acacccaaca caccttgcag ctgctgcaag tgctgagagg     5400

gaacgggaac gggagcggga gaaggagcgg gagcgggaac ggattgctgc agcttcctcc     5460

gacctctacc tgcggccagg ctcagaacag cctggccgac ctggcagtca tggatatgtt     5520

cgctcccctt ccccttcagt aagaactcag gagaccatgt tgcaacagag acccagtgtt     5580

ttccaaggaa ccaatggaac cagtgtaatc acacctttgg atccaactgc tcagctacga     5640

atcatgccac tgcctgctgg gggcccttca ataagccaag gcctgccagc ctcccgttac     5700

aacactgctg cggatgccct ggctgctctt gtggatgctg cagcttctgc accccagatg     5760

gatgtgtcca aaacaaaaga gagtaagcat gaagctgcca ggttagaaga aaatttgaga     5820

agcaggtcag cagcagttag tgaacagcag cagctagagc agaaaaccct ggaggtggag     5880

aagagatctg ttcagtgttt atacacttct tcagcctttc caagtggcaa gccccagcct     5940

cattcttcag tagtttattc tgaggctggg aaagataaag ggcctcctcc aaaatccaga     6000

tatgaggaag agctaaggac cagagggaag actaccatta ctgcagctaa cttcatagac     6060

gtgatcatca cccggcaaat tgcctcggac aaggatgcga gggaacgtgg ctctcaaagt     6120

tcagactctt ctagtagctt atcttctcac aggtatgaaa cacctagcga tgctattgag     6180

gtgataagtc ctgccagctc acctgcgcca ccccaggaga aactgcagac ctatcagcca     6240

gaggttgtta aggcaaatca agcggaaaat gatcctacca gacaatatga aggaccatta     6300

catcactatc gaccacagca ggaatcacca tctccccaac aacagctgcc cccttcttca     6360

caggcagagg gaatggggca agtgcccagg acccatcggc tgatcacact tgctgatcac     6420

atctgtcaaa ttatcacaca agattttgct agaaatcaag tttcctcgca gactccccag     6480

cagcctccta cttctacatt ccagaactca ccttctgctt tggtatctac acctgtgagg     6540

actaaaacat caaaccgtta cagcccagaa tcccaggctc agtctgtcca tcatcaaaga     6600

ccaggttcaa gggtctctcc agaaaatctt gtggacaaat ccaggggaag taggcctgga     6660

aaatccccag agaggagtca cgtctcttcg gagccctacg agcccatctc cccaccccag     6720

gttccggttg tgcatgagaa acaggacagc ttgctgctct tgtctcagag gggcgcagag     6780

cctgcagagc agaggaatga tgcccgctca ccagggagta taagctactt gccttcattc     6840

ttcaccaagc ttgaaaatac atcacccatg gttaaatcaa agaagcagga gatttttcgt     6900

aagttgaact cctctggtgg aggtgactct gatatggcag ctgctcagcc aggaactgag     6960

atctttaatc tgccagcagt tactacgtca ggctcagtta gctctagagg ccattctttt     7020

gctgatcctg ccagtaatct tgggctggaa gacattatca ggaaggctct catgggaagc     7080

tttgatgaca aagttgagga tcatggagtt gtcatgtccc agcctatggg agtagtgcct     7140

ggtactgcca acacctcagt tgtgaccagt ggtgagacac gaagagagga aggggaccca     7200

tcacctcatt caggaggagt ttgcaaacca aagctgatca gcaagtcaaa cagcaggaaa     7260

tctaagtctc ctatacctgg gcaaggctac ttaggaacgg aacggccctc ttcagtctcc     7320

tctgtacatt cagaagggga ttaccatagg cagacgccag ggtgggcctg ggaagacagg     7380

ccctcttcaa caggctcaac tcagtttcct tataaccctc tgactatgcg gatgctcagc     7440

agtactccac caacaccgat tgcatgtgct ccctctgcgg tgaaccaagc agctcctcac     7500

caacagaaca ggatctggga gcgagagcct gccccactgc tctcagcaca gtacgagacc     7560

ctgtcggata gtgatgactg aactgcacaa agtgagggga acagggtgca ggagagggat     7620

ctctagtttt tgtggtttaa tttttagtag caggtcaaaa acctgccctc ctgtgactta     7680

ttccctgaga cttttcagga gagccagccc acagatgatg aagaaatgat ggaagttcat     7740

ttggagagtc aaatgggaaa aaaacaaaca aaaaactgcc tttgatacag gcaattcagt     7800

ggactataat aatagtggag ggttgagatg tagagttttt aaaaagtgaa cagttgctgt     7860

tcttacatct gtaaagaaaa ccataatgtc tttaaatcac tcttctgtaa atagatgacc     7920

tttttgcagt gtatatcccc ttgctgtagt atctggtgta cttatgttca aatcagcgca     7980

tcaactttgg gggtgatttt taaaaatctt tttgtctatc tatcttttta accctagcct     8040

tctaaacaac ctcatacagc ccagttacat aatgttggct gtcacgggca ttgtactttt     8100

atctgatatt gtttcctcta aattcagctt tccagtgatg tttaaaatct tgtgaaaatg     8160

tttagatttt taacacagac cctgtcataa aatctgtaca ttagggtcaa aaggtaaaag     8220

taacaaattc tgccatattg taaatttcca gtgcaggctt taattttttt ttttcattag     8280

tagcactgaa aaaatattac tgcatgggta tgttctagtt cagtttataa agttttaaag     8340

gcttatttga ggcatacctc actgttacgc acactggtaa tttaaccatg cccctaagta     8400

ttccttttct cctgcatttg atgcagccca acaaagcttt tgttttgaaa taaatttgac     8460

taccctgtcc ata                                                        8473


<210> 481
<211> 3326
<212> DNA
<213> Homo sapiens

<400> 481
gcacttccgg gccggccgat tccgcgcgtc tccgcccatc atggcgctcg tgccagtgtc       60

ccgtgggcta cccactcctg tcatgtcctt tgggctggtg caggccagat cttctagggc      120

cgtagccctg agaggagcgc ctggagagga aacggcgcgc catgcacctc acacggcccc      180

tcagacctca cggcgaggcc ctatcagggt aatggtgtcc gccggactcg cacaacactc      240

cgccggactc gcacaacact ccgccgcact cgcacaagac tccgccgcgg cgacctctac      300

tgaaagaccc ccagtcctgg tgtcgcccga aggcccagga aaccgtgctt ccgcgcttct      360

cccccagaac gtgggaagct gccgctttac cctcatttta ccccagggtc gcaaaacatc      420

tcaccgtagt tgaagccagc aagccggacc aggcgtcccg gccaagccac gtgcgcgccc      480

cgcgccgcga gtgctcgccc cgcccctagg gaggagccgg ccgacccccg gccacttagc      540

agtgccgcag ccgacggggt gcggttcggc gctcccaggt tcctttcctc actgcacgct      600

cttgcccctc ctcttttctc tcctgcccgt gttcttcccg ccgcctgacc tggcccgccc      660

gcctttccag tctggccggg cgggggcctg aagcacggcg gctcgggccg tgggaccgtg      720

ttcacaccct ttccagaaat tcttggctgg taaccgcgaa accgactgga gcaggagctg      780

ggagaactgg agaaaactgc tctaatctca cttgactcca gctaggagct gatgctgcat      840

cgtaataaca tttgcagagc gctttcacag gcgctggagt gacttgtctg agattcctcc      900

agaactgagc cctttgttgg aaccataccc cagcccatgg tcccatgact aggtggatag      960

tactccttgt acctcctgca acccagaacc ctggctgacc actttgaagg aggatgctcc     1020

agcaggtcaa tggccacaat ccggggtctg atggccaagc cagggagtac ctcagagaag     1080

acctgcagga gttcctgggt ggggaggtcc tgctgtacaa actggatgac ctcaccaggg     1140

tgaatcctgt gacactagag acagtcctga ggtgcctgca ggcccggtac atggcagaca     1200

cattctacac caatgctggc tgcaccctgg tagccttgaa ccccttcaag cctgttcctc     1260

agctctactc gcccgagcta atgagagagt accatgctgc gcctcagccc cagaaactga     1320

agccccatgt gttcactgtg ggtgaacaga cctacaggaa tgtcaagagc ctgattgaac     1380

cagtcaacca gtctattgtt gtcagtggag agagtggtgc tggaaagaca tggacgtctc     1440

gctgcctaat gaagttctat gctgtggtgg ccacctcacc tgcatcttgg gagagccaca     1500

agattgcaga gaggatagaa cagaggatcc tgaactccaa ccctgtcatg gaagcttttg     1560

ggaatgcgtg tacactgagg aataacaaca gcagtcgctt tgggaagttc atccagctcc     1620

agctgaacag ggctcagcaa atgactggag ccgcagtcca gacctacctc ctagagaaaa     1680

ctcgagtggc ctgccaggct tccagtgaga ggaacttcca catcttctat cagatttgca     1740

aaggagccag tgaggacgag aggctccagt ggcaccttcc tgagggagct gccttctcct     1800

ggctgcccaa cccagagagg agcttagaag aggattgttt tgaggtgacc agagaggcca     1860

tgctccattt gggcattgac acccctaccc agaacaacat ctttaaggtc ctagctggac     1920

tgctgcacct tggcaatatc cagtttgctg cctccgagga tgaagcccag ccctgccagc     1980

cgatggatga tgccaagtac tctgtcagga cggcagcctc gctgctgggg ctcccagagg     2040

acgtgctgct ggagatggtg cagattagaa ccatcagggc aggcagacag cagcaggtgt     2100

tccggaagcc ctgcgcccga gccgagtgtg acacccgtag agactgcctg gccaaactga     2160

tctatgcgcg gttgtttgac tggctggtat cagtgatcaa cagcagcatc tgtgcagaca     2220

ccgactcgtg gaccactttc ataggcctgc tggatgtgta tggatttgaa tcatttcctg     2280

acaacagtct ggaacagttg tgcatcaact acgccaatga gaagctccag ctggaggcct     2340

gtggcctcgt ggagaccatc catatcagtg ctgctggctt ccccatccgg gtctctcacc     2400

gaaactttgt agaacgatac aagttactaa gaaggcttca tccttgcaca tcctctggcc     2460

ccgacagccc atatcctgcc aaagggctcc ctgaatggtg tccacacagc gaggaagcca     2520

cgcttgaacc tctcatccag gacattctcc acactctgcc ggtcctaact caggcagcag     2580

ccataactgg tgactcggct gaggccatgc cagcccccat gcactgtggc aggaccaagg     2640

tgttcatgac tgactctatg ctggagcttc tggaatgtgg gcgtgcccgg gtgctggagc     2700

agtgtgcccg ctgcatccag ggtggctgga ggcgacaccg gcaccgagag caggagcggc     2760

agtggcgggc cgtcatgctc atccaggcag ccattcgttc ctggttaact cggaaacaca     2820

tccagaggct gcatgcagct gccacagtca tcaagcgtgc atggcagaag tggagaatca     2880

gaatggcctg ccttgctgct aaagagctgg atggtgtgga agaaaaacac ttctctcaag     2940

ctccctgttc cctgagcacc tcgccgctgc agaccaggct cctggaggca ataatccgcc     3000

tctggcccct gggactggtc ctggccaata cggctatggg tgtaggcagc tttcagagga     3060

aattagtggt ctgggcttgc ctccagctcc ccaggggcag ccccagtagc tacactgtcc     3120

agacagcaca agaccaggct ggtgtcacgt ccatccgagc gctgcctcag ggatcgataa     3180

agtttcactg cagaaagtct ccactgcggt atgctgacat ctgccctgaa ccttcaccct     3240

acagcattac aggctttaat cagattctgc tggaaagaca caggctgatc cacgtgacct     3300

cttctgcctt cactgggctg gggtga                                          3326


<210> 482
<211> 5675
<212> DNA
<213> Homo sapiens

<400> 482
agactgaggc tggctggctg gaggttgaca caggagtgct caggggagca gcatcacaag       60

agggcagatc gaaagcatcg tccttgctga aaaacagatg gcagaggtgg aagcggtaca      120

gctgaaggag gaaggaaacc ggcatttcca gctccaggac tacaaggccg ccacaaatag      180

ctacagccag gccctgaagc tgaccaagga caaggccctg ctggccacgc tttatcggaa      240

ccgggcagcc tgtggcctga aaacggagag ctacgtccag gcagcttcag atgcctccag      300

agccatcgac atcaactcct cggacatcaa ggctctgtat cggcgatgcc aggcactgga      360

gcacctgggg aagctggacc aggccttcaa agacgtgcag cgttgtgcca ccctcgagcc      420

acggaaccag aacttccagg agatgctgag gagactcaac accagcattc aggagaagct      480

ccgagtgcag ttctccacag actcgagggt acagaagatg tttgagatcc tcttggatga      540

aaacagtgag gctgataagc gggaaaaggc tgccaacaat ctcattgtcc taggccgtga      600

ggaagcaggg gctgagaaga tcttccagaa caatggagta gccttgctac tgcagcttct      660

ggacactaag aagcctgagc tggtgctggc tgcagtgcgg accctgtcgg gcatgtgcag      720

cggccaccaa gccagagcca cagtgattct gcatgcagtg cggatagacc gaatctgtag      780

cctcatggcc gtggagaatg aggagatgtc tctggctgtc tgcaacctgc tccaagccat      840

cattgactcc ttgtctgggg aggacaagcg ggagcatcga gggaaggagg aggccctggt      900

tctagacacc aagaaggacc tgaagcagat caccagccac ctgctggaca tgctagtcag      960

caagaaggtg tctggccagg gcagggatca ggcgctgaac ctgctcaata agaatgttcc     1020

caggaaggac cttgccattc atgacaactc acgtaccatc tatgtggtgg ataatggtct     1080

gaggaagatc ctgaaggttg tggggcaggt tccagatctg ccatcctgcc tgcccctgac     1140

tgacaacacc cgcatgctgg cctctatcct catcaacaag ctctatgatg acctgcgctg     1200

tgacccggag cgcgatcact tccgcaagat ctgtgaggaa tatatcacgg gcaagtttga     1260

cccccaggac atggacaaga acttgaatgc catccagaca gtgtcaggga tcctgcaggg     1320

cccctttgac ctgggcaacc agctgctggg actgaaaggt gtgatggaga tgatggtggc     1380

actatgtggc tcagagcgcg agacggacca gctggtggcc gtggaggccc tcatccatgc     1440

ctccacgaag ctcagccgcg ccaccttcat catcaccaat ggagtgtcac tgctcaaaca     1500

gatctacaag accaccaaaa atgagaagat caagatccgc acactggtgg gactctgtaa     1560

gctcggctct gcaggtggca cagactacgg tctcaggcag tttgcggaag ggtcgacaga     1620

aaaactggcc aaacagtgtc gcaagtggct gtgcaatatg tccatagaca ctcggacccg     1680

acgctgggca gtggagggcc tggcctacct cacgctggac gctgatgtga aggacgactt     1740

tgtccaggac gtccctgccc tgcaggccat gtttgagctg gccaaggcag gtaccagtga     1800

caagaccatc ctgtactcgg tggccaccac cctggtgaac tgcaccaaca gctacgatgt     1860

caaggaggtc atcccagagc ttgtccagct cgccaagttc tccaagcagc atgtgcccga     1920

ggaacacccc aaggacaaga aggactttat agacatgcgg gtgaagcggc ttctgaaggc     1980

gggtgtcatc tctgccctgg cttgcatggt gaaagcagat agtgccatcc tcactgacca     2040

gaccaaggag ctgctggcca gggtattcct ggcactgtgt gacaacccaa aggaccgagg     2100

caccattgtg gctcaaggtg gtggcaaggc cctgattccc ctggctttgg agggcacaga     2160

tgtgggcaag gtgaaggcag cccacgctct agcaaagatc gctgctgtct ccaatccgga     2220

cattgctttt cctggggagc gggtgtatga ggtggtgcgg ccccttgtaa gactcttgga     2280

cacacagagg gatgggcttc agaactatga ggctctccta ggcctcacca acctgtctgg     2340

gcggagtgac aaactccggc agaagatctt taaggagagg gccttgccag acatcgagaa     2400

ctacatgttt gagaatcatg atcagctgcg gcaggcggcc accgagtgca tgtgcaacat     2460

ggtgctccac aaggaggtac aggaaaggtt cttggctgac gggaatgacc ggctgaagct     2520

ggtggtgctg ctctgcgggg aggatgatga taaggtgcag aatgcggctg caggggctct     2580

ggccatgctg acagcagcac acaagaaact gtgcctcaag atgactcaag tgacaaccca     2640

gtggttggag atcctccagc ggctttgcct gcacgaccag ctgtctgtcc aacaccgggg     2700

cctggtcatt gcctacaacc tactggcagc cgatgctgag ctggccaaga agctggtgga     2760

gagtgagctg ctggagatcc tgactgtggt gggcaaacag gagccagatg agaagaaggc     2820

agaagtggtt cagacagccc gagaatgtct catcaagtgc atggattatg gtttcattaa     2880

accagtgtct tagacagcga ccctcaggga tgctgggagt ggtcctgtac tgtgcagagt     2940

cctgggttgg ttgggttctc ctgaagagtc aggtcatcta gggatcatag cagtgacaat     3000

gaagtctcaa tataaaggaa agacttgatt gttctctgag ttgtgagtct tctcctttgt     3060

cctgacagag tttggatgtt tcactctctc tcttgcttcc tgtctcctta tatttgtcat     3120

gtttcagaaa ttcccagaat aattttcacc catgattaga aataggttgg atcattcttt     3180

ctgtacccat tctgaaggcc aggataatag gttgaagttc tttatatttt ggaaaatgga     3240

ttttgtggta aggtaggaac taacgggtgt gtgcatataa aggttaatgc tgttgtattt     3300

ggatgctgat ctgtgctgtt ttcatgacct ctctcccaca ctatttgaat cagtctgttc     3360

agaactgtgt gtttcacctg cagtgctctg tcccagtccc atgcccattc ccatcacttc     3420

actgtgatgg aaatagagtt tatgttcaac agtggggcat gacctctgca atttgcttgg     3480

gaaagtcttc caagcaagat ggacatgatg aatacaaata agatctactc aaagtacttc     3540

aaacaaaaaa taaataattc attggctcat gtatcttggc cacccaggga aggtctgaca     3600

ttgttagtta gatccagagt ttcaaatgtc atcaccatgg atgtgtcttt ttctctctct     3660

catttcccct ccccatatct tgtcttttat ttattatagg tttgtctcat tccctggcag     3720

gctctctccc tgtgatagga aagagagtcc ccagcagccc cagggtgaca tagttgttat     3780

agttcattat ggaatagaag agagaagagc attctcaata acccggcaaa gttcccaggg     3840

atgactctga tatgtctatg tctcaggtca catttccatc tatgaaccaa tcatattcag     3900

aggtggaatg ctaattggcc aggcctgggt catatataca agtctaggga agaaatgagc     3960

ttcatccctg tccaattgac atggactgat taggggtatt aatggaagag gtgtgccacc     4020

acaaaagaat gtaccctggg cagatcaaag aacatattct gtatgtcagg cttggccaca     4080

aaagaatgac acaagtaata tgctgtagat cagaacctct ctgctaatat tgccttttta     4140

gcatggttaa gatagctaag atctagtact gtcactccag tatgtcccaa ttctacctac     4200

gtttattgaa gggtcaacag ttctgatctc agcattgggt aaagggtggg acattcagat     4260

ttacggtcct tgataaaaac aatttacaac gttccgttgt gtaataaatg taagtgtaca     4320

tatgcctggg acatcagctg gaaaagggac agactatcag agagttgcac tgttgcggta     4380

tgggccaaat ccaacataat acccgctgta cctctagaga actaaaacct taatttctca     4440

gatcttttct gcactaatgg tctttacata cagcctacat tttaactaac tcttgcatgg     4500

gcttgtttca cagcaggaaa ctatattcat catatcctta ttatgataga gaatgacaac     4560

attcaaaagg gtgtggtgct tctgaaaata tacacaataa atggcatgat ttgacctctg     4620

tcaaattctt ctttcctgct ttcctcatat gtgggcttga gtgggtgtat ttagctcctt     4680

taaaggaaac tctttcacag gcagggccac actcttactc gttttgatct catgaggtta     4740

catctgccag tggcgttcag ggccagttag ataaagttca tcttgtttgg attggagaga     4800

cttttttttt tttttttttt gagacagggt cttgctctgt aacctaggct caagtgcagt     4860

gcagtggtgc agtcatggct caccgcagcc ttggtctcct gggctcaagt gatctttcta     4920

cttcagcctc ctcaatagct gggactacag gcacacacca ccacccccag gtaattaaaa     4980

aatttttttt tgtagagaca gggtctcact atgttgccca gtctgggaga ccacattctt     5040

taacatgaat attttgtaaa tagtccaaga agatctagag gaaagctgaa ttccttcatc     5100

tgatttttgc cactgggctg cctcccattg tctggctaag tcttcatggg aggcctttaa     5160

gaaaagctgt gacaaatacc tttgtttccc actgcctagg ttacataagt agttggcttt     5220

tccagcctag actcttatat tgttgcttgt aagagggccc ttctttgcag atttcttttt     5280

tttttcatct atgctttcaa ataggcagat gctagcctga gatcatctct ttattgaggt     5340

agtttgccca aaaacagcaa ggaacagcca atacctgcca actttctagg tttttccaac     5400

caattctctt acagaaaatc tataaatatc ttagaggtat gtttcttagt ttcccaacat     5460

ataatgggaa aattcatcat ttatattatt acttttaact gaagtatgtt gttatcagag     5520

aacttggtct gtgtcatatt aatcctttgc catttgagaa gcatacagtt ttaaagttta     5580

tatctccaaa aggatatttt gtaaaaattt aacccctttg actcttagtc ttctcatttg     5640

tgaaaggtaa ataataaaga atttctgttc ctagt                                5675


<210> 483
<211> 2335
<212> DNA
<213> Homo sapiens

<400> 483
gtagtggccc cagtccgggc cccggcgcgc taggctcaca aaggcaggca cagactgcaa       60

ccctgctcag tgctccgggc gcttcaggct ggcttgggtc ctgctgctcc aaccccaagg      120

gccctggagc gctccctgat acctccatca ctcaccatgg ccagccagtt ctgcctccct      180

gaatccccat gtctctcgcc cctgaaaccc ttgaagccac atttcggaga catccaagag      240

ggcatctacg tggcgatcca gcgcagtgac aagcggatcc acctcgctgt ggtcacggag      300

atcaacagag aaaactattg ggtcacggta gagtgggtgg agaaagcagt caaaaaaggc      360

aagaagattg acctggagac catactcctg ctgaatccag ctctggactc tgctgaacac      420

cccatgccgc ccccgccctt atcccccttg gctctggcgc cctcttcggc catcagggac      480

cagcgtaccg ccacgaaatg ggttgcgatg atcccccaga aaaaccaaac agcctcaggg      540

gacagcctgg atgtgagggt ccccagcaaa ccttgtctga tgaagcagaa aaagtctccc      600

tgcctctggg aaatccagaa actgcaggag cagcgggaaa agcgcaggcg gctgcagcag      660

gagatccgag ctagacgcgc cctcgatgtc aataccagaa accccaacta cgaaatcatg      720

cacatgatcg aagagtatcg caggcacctg gacagcagca agatctcagt cctggagccc      780

ccgcaagaac atcgcatctg cgtctgcgtg aggaagcggc ctctcaacca gcgagagaca      840

accttaaagg acctggatat catcaccgtc ccctcggaca atgtggttat ggtgcatgag      900

tccaagcaaa aggtggacct cactcgctac ctgcagaacc agaccttctg cttcgaccat      960

gccttcgatg acaaagcctc caacgagttg gtgtaccagt tcaccgccca gccactggtg     1020

gagtccatct tccgcaaggg catggccacc tgctttgcct atgggcagac gggaagtggg     1080

aagacgtaca ccatgggtgg agacttttca ggaacggccc aagattgttc taagggcatt     1140

tatgctctgg tggcacagga tgtctttctc ctgctcagaa actccacata tgagaagctg     1200

gacctcaaag tctatgggac attttttgag atttatgggg gcaaggtgta tgatttgttg     1260

aactggaaga agaagctgca agtccttgag gatggcaatc agcaaatcca agtggtcggg     1320

ctgcaggaga aagaggtgtg ttgtgtggag gaagtgctga acctggtgga aatagggaat     1380

agctgtcgga cttccaggca aacacctgtc aacgctcact catccaggag ccatgcagtg     1440

ttccagatca tcctgaagtc aggacggata atgcatggca agttttccct cgttgattta     1500

gctgggaatg aaagaggagc agatacaacc aaggccagcc ggaaaaggca gctggaaggg     1560

gcagagatta acaagagtct tctagccctc aaagaatgta ttctggcttt gggtcagaac     1620

aagcctcaca ccccattcag agccagcaaa ctcacactgg tgctccggga ctcctttata     1680

ggccagaact cctccacttg catgattgct accatctctc cggggatgac ctcttgtgaa     1740

aacactctca acactttaag atatgcaaac agagtaaaaa aattaaatgt agatgtaagg     1800

ccctaccatc gtggccacta tccgattgga catgaggcac caaggatgtt aaaaagtcac     1860

atcggaaatt cagaaatgtc ccttcagagg gatgaattta ttaaaatacc ttatgtacag     1920

agtgaggagc agaaagagat tgaagaggtt gaaacattac ccactctgtt agggaaggat     1980

accacaattt cagggaaggg atctagccaa tggctggaaa acatccagga gagagctggt     2040

ggagtacacc atgatattga tttttgcatt gcccggtctt tgtccatttt ggagcagaaa     2100

attgatgctc tgaccgagat ccaaaagaaa ctgaaattat tactagctga cctccacgtg     2160

aagagcaagg tagagtgaag ccaatggcga gagatcaggt ccgaaatgct gcattgctgc     2220

agtttccacc actcttatac aggaaaactg tccaaattat ctaaagatcc tcctgagaag     2280

cttaaaacat cttaaaatac actgatggga aacatgctct ttcttctgcc tctgt          2335


<210> 484
<211> 1734
<212> DNA
<213> Homo sapiens

<400> 484
acgcacgcac gtctctcgct ttcgcatact taaggcgtct gttctcggca gcggcacagc       60

gaggtcggca gcggcacagc gaggtcggca gcggcacagc gaggtcggca gcggcacagc      120

gaggtcggca gcggcagcga ggtcggcagc ggcacagcga ggtcggcagc ggcagcgagg      180

tcggcagcgg cgcgcgctgt gctcttccgc ggactctgaa tcatggcgac cacggccacg      240

atggcgacct cgggctcggc gcgaaagcgg ctgctcaaag aggaagacat gactaaagtg      300

gaattcgaga ccagcgagga ggtggatgtg acccccacgt tcgacaccat gggcctgcgg      360

gaggacctgc tgcggggcat ctacgcttac ggttttgaaa aaccatcagc aatccagcaa      420

cgagcaatca agcagatcat caaagggaga gatgtcatcg cacagtctca gtccggcaca      480

ggaaaaacag ccaccttcag tatctcagtc ctccagtgtt tggatattca ggttcgtgaa      540

actcaagctt tgatcttggc tcccacaaga gagttggctg tgcagatcca gaaggggctg      600

cttgctctcg gtgactacat gaatgtccag tgccatgcct gcattggagg caccaatgtt      660

ggcgaggaca tcaggaagct ggattacgga cagcatgttg tcgcgggcac tccagggcgt      720

gtttttgata tgattcgtcg cagaagccta aggacacgtg ctatcaaaat gttggttttg      780

gatgaagctg atgaaatgtt gaataaaggt ttcaaagagc agatttacga tgtatacagg      840

tacctgcctc cagccacaca ggtggttctc atcagtgcca cgctgccaca cgagattctg      900

gagatgacca acaagttcat gaccgaccca atccgcatct tggtgaaacg tgatgaattg      960

actctggaag gcatcaagca atttttcgtg gcagtggaga gggaagagtg gaaatttgac     1020

actctgtgtg acctctacga cacactgacc atcactcagg cggtcatctt ctgcaacacc     1080

aaaagaaagg tggactggct gacggagaaa atgagggaag ccaacttcac tgtatcctca     1140

atgcatggag acatgcccca gaaagagcgg gagtccatca tgaaggagtt ccggtcgggc     1200

gccagccgag tgcttatttc tacagatgtc tgggccaggg ggttggatgt ccctcaggtg     1260

tccctcatca ttaactatga tctccctaat aacagagaat tgtacataca cagaattggg     1320

agatcaggtc gatacggccg gaagggtgtg gccattaact ttgtaaagaa tgacgacatc     1380

cgcatcctca gagatatcga gcagtactat tccactcaga ttgatgagat gccgatgaac     1440

gttgctgatc ttatctgaag cagcagatca gtgggatgag ggagactgtt cacctgctgt     1500

gtactcctgt ttggaagtat ttagatccag attctactta atggggttta tatggacttt     1560

cttctcataa atggcctgcc gtctcccttc ctttgaagag gatatgggga ttctgctctc     1620

ttttcttatt tacatgtaaa taatacattg ttctaagtct ttttcattaa aaatttaaaa     1680

cttttcccat aaactctata cttctaaggt gccaccacct tctctagtaa ctta           1734


<210> 485
<211> 2664
<212> DNA
<213> Homo sapiens

<400> 485
cgagcgcgag ccgggagccg gggcgggcgc gggcagcggc gggccggccg ggctgtgcgg       60

ggcgagcggc ggcggcggcg ggggcgcttc ggccggggcg gcagctgggc gccggcggga      120

gctagcagcg tctgcagccg cgccggccgc cagcgccccg gcgcgctccg gctcggccat      180

ggagctgcca gctgttggcg agcacgtctt cgcggtggag agcatcgaga agaagcggat      240

ccgcaagggc agagtggagt atctggtgaa atggagaggc tggtcgccca aatataacac      300

gtgggaaccg gaggagaaca tcctggaccc caggctgctg atcgccttcc agaacaggga      360

acggcaggag cagctgatgg gatatcggaa gagagggccg aagcccaaac cgctagtggt      420

gcaggtgcct acctttgccc gtcgttccaa tgtcctgacc ggcctccagg actcctccac      480

tgacaaccgt gccaagctgg atttgggcgc gcaggggaag ggccaggggc atcagtacga      540

gctcaacagc aagaagcacc accagtacca gccgcacagc aaggagcggg cgggcaagcc      600

cccgccgccg ggcaagagcg gcaagtacta ctaccagctc aacagcaaga agcaccaccc      660

ctaccagccc gaccccaaaa tgtacgacct gcagtaccag ggcggccaca aggaggcgcc      720

cagccccacc tgcccggacc tgggggccaa gagccacccg cccgacaagt gggcgcaagg      780

tgcgggggcc aaaggctacc tgggggcggt gaagcccctg gccggtgcgg cgggtgctcc      840

aggcaaaggc tccgagaagg gcccccccaa cggaatgatg ccggccccca aagaggctgt      900

gacgggcaac gggattgggg gcaagatgaa gatagtcaag aacaagaaca agaacggacg      960

catcgtgatc gtgatgagca aatacatgga gaacggcatg caggcggtga agatcaagtc     1020

cggcgaggtg gcagaggggg aggctcgctc ccccagccac aagaagcggg cagccgacga     1080

gcgccaccct cctgccgaca ggacttttaa aaaggcggcg ggcgcagagg agaagaaggt     1140

ggaggcgccg cccaagagga gggaggagga ggtgtccggg gttagcgatc cgcagcccca     1200

ggatgccggc tcccgcaagc tgtccccgac caaggaggcc tttggagagc agcccctgca     1260

gctcaccacc aagcccgacc tgcttgcctg ggacccggcc cggaacacgc acccgccctc     1320

acaccacccg cacccgcacc cccatcacca ccaccaccac caccaccacc accaccacgc     1380

cgtcggcctg aatctctccc acgtgcgcaa gcgctgcctc tccgagaccc acggcgagcg     1440

cgagccctgc aagaagcggc tgactgcgcg cagcatcagc acccccacct gcctgggggg     1500

cagcccagcc gctgagcgcc cggccgacct gccaccagcc gccgccctcc cgcagcccga     1560

ggtcatcctg ctagactcag acctggatga acccatagac ttgcgctgcg tcaagacgcg     1620

cagcgaggcc ggggagccgc ccagctccct ccaggtgaag cccgagacac cggcgtcggc     1680

ggcggtggcg gtggcggcgg cagcggcacc caccacgacg gcggagaagc ctccagccga     1740

ggcccaggac gaacctgcag agtcgctgag cgagttcaag cccttctttg ggaatataat     1800

tatcaccgac gtcaccgcga actgcctcac cgttactttc aaggagtacg tgacggtgta     1860

gccggagggc gtcggaaggg gaagcgccat tcccgcgggg gggcggggag ctgagcacct     1920

ggggcctcgg ggcgggctcc cctctcgcca acccgccaac cgcgagagac ccaggctggc     1980

ccccagggtg aggacgcccg gagcggaggt aaccatgttc cccctgcggc ggctgtcaga     2040

cctgggcgga ggccccttcc acgcggtgcc ggcggggctc gccctctcct gcccttcccc     2100

gctggagatg gacccccgga acggacaggg cagctctgcg cccggcctca gagttctagt     2160

attatatttt aaccgtgcta acttgtcaag tgctgactct actcccgttt gtacgtggtg     2220

ttattattga aatgtattgt ttgagctcaa aaggcccgac cacccccctt cgggctgcta     2280

tatatatatt tatttgtagg tatttatata ttgaaatata aaaacctaga tttatggagt     2340

ttcctctaga tcatgttata ttctatatca gacaaactat tttcttttga cctttcttcc     2400

cctccatcca gtatttcggt tgatttcatt ttctcccctc tcttcccctt ccacgaactg     2460

caataccagt aaccttggta tatatttttt gatactgtac acatggatgt cttgtttcta     2520

tgtgcaaaaa aaaaaaaaaa aaaaagtttg ttaaaaggct acacgagctc tctagaaact     2580

gctgctacta gaaatgtcta aactataagc ttccaactat tacctgcttg aatgtaaata     2640

ttaaatggag atgttgaagg tgca                                            2664


<210> 486
<211> 1218
<212> DNA
<213> Homo sapiens

<400> 486
atggactctc ttgttacagc aaacaccaaa ttttgctttg atctttttca agagataggc       60

aaagatgatc gtcataaaaa catatttttc tctcccctga gcctctcagc tgcccttggt      120

atggtacgct tgggtgctag aagtgacagt gcacatcaga ttgatgaggt actacacttc      180

aacgaatttt cccagaatga aagcaaagaa cctgaccctt gtctgaaaag caacaaacaa      240

aaagctgggt ccttaaacaa tgagagcgga ctggtcagct gctactttgg gcagcttctc      300

tccaaattag acaggatcaa gactgattac acactgagta ttgccaacag gctttatgga      360

gagcaggaat tcccaatctg tcaggaatac ttagatggtg tgattcaatt ttaccacacg      420

acgattgaaa gtgttgattt ccaaaaaaac cctgaaaaat ccagacaaga gattaacttc      480

tgggttgaat gtcaatccca aggtaaaatc aaggaactct tcagcaagga cgctattaat      540

gctgagactg tgctggtact ggtgaatgct gtttacttca aggccaaatg ggaaacatac      600

tttgaccatg aaaacacggt ggatgcacct ttctgtctaa atgcgaatga aaacaagagt      660

gtgaagatga tgacgcaaaa aggcctctac agaattggct tcatagagga ggtgaaggca      720

cagatcctgg aaatgaggta caccaagggg aagctcagca tgttcgtgct gctgccatct      780

cactctaaag ataacctgaa gggtctggaa gagcttgaaa ggaaaatcac ctatgaaaaa      840

atggtggcct ggagcagctc agaaaacatg tcagaagaat cggtggtcct gtccttcccc      900

cggttcaccc tggaagacag ctatgatctc aattccattt tacaagacat gggcattacg      960

gatatctttg atgaaacgag ggctgatctt actggaatct ctccaagtcc caatttgtac     1020

ttgtcaaaaa ttatccacaa aacctttgtg gaggtggatg aaaacggtac ccaggcagct     1080

gcagccactg gggctgttgt ctcggaaagg tcactacgat cttgggtgga gtttaatgcc     1140

aaccaccctt ttctcttttt cattagacac aacaaaaccc aaaccattct cttttatggc     1200

agggtctgct ctccttaa                                                   1218


<210> 487
<211> 5518
<212> DNA
<213> Homo sapiens

<400> 487
atgctgagga tgaagctgcc gctgaagcca acgcaccccg cggagccgcc gcccgaggcg       60

gaggagcccg aggcggacgc gcggccgggc gcgaaggcgc cttcgcgccg ccgccgcgac      120

tgccgccccc cgccgccgcc gccgccgccc gcgggcccgt cgcggggccc tctgccgccg      180

ccgccgccgc cccggggact cgggccgcct gttgctggtg gagcggcggc gggggcgggt      240

atgccgggcg gcggcggggg gccctcggcg gcgctgcgcg agcaggagcg ggtatacgag      300

tggttcgggc tggtgctggg ctcggcgcag cgcctggagt tcatgtgcgg gctgctggac      360

ctgtgcaacc cgctggagct gcgcttcctt ggctcgtgcc tggaggacct ggcgcgcaag      420

gactaccact acctgcgcga ctcggaggcc aaggccaacg gcctctcgga cccggggccg      480

ctggccgact tccgagagcc cgcggtgcgc tcgcgcctca tcgtctacct ggcgctgctg      540

ggctcggaga accgggaggc cgctggccgt ctgcaccgcc tgctacccca ggtggactcg      600

gtgctcaaaa gcctgcgcgc ggcccggggc gagggctcgc ggggcggcgc ggaggacgag      660

cgcggcgagg acggcgacgg cgagcaggac gccgagaagg acggctcagg cccggaaggc      720

ggcattgtgg agccccgggt cggcggcggg cttggctcca gggcccagga ggaactgctg      780

ctgctcttca ccatggcctc gctgcacccg gctttctcct tccaccagcg ggtcaccctg      840

agggaacact tggagaggct ccgcgccgcg ctccgcgggg gccccgagga cgcggaggtg      900

gaggtagagc cgtgcaagtt tgccggcccc agggcccaga acaactctgc tcatggtgat      960

tacatgcaaa ataacgagag cagcttaata gagcaagctc caatacctca ggacggactt     1020

accgtggcac ctcacagagc tcagcgagaa gctgtacaca ttgagaagat aatgttgaaa     1080

ggagtccaga gaaaaagagc tgacaaatac tgggagtaca ctttcaaagt aaattggtct     1140

gatctttcag tcacaacagt aacaaaaacc caccaagaac tacaggaatt tctactgaag     1200

cttccaaagg aactgtcttc agagactttt gacaagacca tcttaagagc cctgaatcag     1260

ggttccttga aaagggagga acggcgacat cctgacctag agcccatcct aaggcagcta     1320

ttttcaagtt catcacaagc ttttctacaa agtcagaaag tacacagctt ctttcagtcc     1380

atatcatcag actccctaca cagtatcaat aacttacaat cctctctgaa gacttctaag     1440

atattagaac acttaaaaga agacagctct gaagcttcaa gtcaagaaga agatgtgttg     1500

cagcatgcca taatccacaa gaagcatact gggaaaagtc ccattgtgaa caatattggt     1560

acaagttgtt ctccattgga tgggcttacc atgcaatatt ctgaacagaa tggaattgtg     1620

gattggagga agcaaagctg taccaccatt caacacccag agcactgtgt gacctcggct     1680

gaccagcatt ctgctgaaaa acggagttta tcttcaataa ataagaagaa aggaaagcca     1740

caaacagaaa aggagaaaat taagaaaact gacaacagat tgaatagtag aataaatggt     1800

attagactct ccactcctca gcatgcccat ggtggtactg tgaaagatgt gaatttggac     1860

attggctctg gacatgacac atgtggagaa acatcttcag agagttacag ttctccatct     1920

agtccccgac atgatggaag agaaagtttt gaaagtgaag aagagaaaga cagagacaca     1980

gacagcaatt ctgaggattc tgggaatcca tcaacaacta ggtttacagg ttacggttct     2040

gtcaaccaga ctgtcactgt caagccacct gttcaaattg cttcactagg aaatgagaat     2100

ggaaaccttt tagaagatcc cttaaactca cccaagtatc agcatatttc ttttatgcca     2160

acgttacact gtgtcatgca caatggtgcc cagaagtctg aagttgtcgt tcctgcaccc     2220

aaacccgctg atggcaaaac catagggatg cttgttccta gtcctgttgc tatttctgca     2280

ataagggagt ctgcaaattc aacccctgtt ggaatactag ggccaacagc ttgcactgga     2340

gaatcggaaa agcaccttga gttactggct tcccctttac ctattccatc aaccttcctt     2400

ccacacagta gtactcccgc tttgcatctt acagttcaga ggctaaagtt gccaccacca     2460

cagggatctt ctgagagctg cacagttaac atcccacaac aaccacccgg aagcctgagc     2520

atcgcatcac caaacactgc ctttattcct atccataacc caggtagttt cccaggctct     2580

cctgttgcta ccacggaccc catcacaaaa tctgcatccc aagtggtagg actcaatcaa     2640

atggtgcctc aaattgaggg aaacacaggg acagtccctc agcctaccaa tgtgaaggta     2700

gttcttccag cagctggcct ctcagctgct cagccaccag cttcctaccc cttaccaggc     2760

tctccccttg ctgccggcgt gttacccagc cagaactcca gtgtgctcag cacagcagca     2820

acttctcccc agccagcgag cgcaggtatc agccaggccc aggcaactgt tcctcctgca     2880

gttcctaccc acaccccagg ccctgccccg agcccaagcc ctgccttgac acacagtacc     2940

gcgcagagtg acagcacctc ttacatcagt gctgtgggga acacgaacgc taatgggaca     3000

gtagtgccac cgcagcagat gggctcaggt ccttgtggtt cttgtgggcg aaggtgcagc     3060

tgtgggacca atggaaacct tcagctaaat agttactatt atcctaatcc aatgcctgga     3120

ccaatgtacc gagtcccttc attctttact ctgccatcca tttgcaatgg cagctacctc     3180

aaccaagcac atcagagcaa tggaaaccaa cttccttttt ttctgcctca gactccatat     3240

gcaaatggac tggtacatga cccagtcatg gggagccaag ccaactatgg catgcagcag     3300

atggcaggat ttgggagatt ctatcctgta tatccagcac ctaacgtagt tgccaacacc     3360

agtggttcgg ggcccaagaa gaatgggaat gtctcatgtt acaattgtgg tgtaagcgga     3420

cactatgcac aggactgtaa gcagtcgtcc atggaggcca atcaacaagg cacttacaga     3480

ctgagatacg cacctcccct ccccccttct aatgatacgt tggattctgc agactgaaac     3540

gagtaaagct tgcctactta atacactcaa gtgtggggag tcatggggtg tggaggggag     3600

gaaaggaaag gtattttgtt tctttgtcta tacatttcct agatttctat gcagttggga     3660

tttttcattt ctcttgtacc aatgtccaaa acaagaaaga atgcaatgct tttgagcctc     3720

tggtctcctg gttcaacaac aggcttatat gtatgataca tgtaatttaa accttcagac     3780

aaacttaaat gttggtgcgt gctttttttt ttttttttac actgaatact tgctgtgtgc     3840

aatgtttact gaatctttaa aactgtgtat ttgacctttt ttttacaaca ctggtgacag     3900

tcatatggtt ttgaaaaaaa aaagaaattt tgcttcttcc cagcttttct cactttcacc     3960

ctaaacgaca cttcctcccc agccagcctc actctgtctc cggcccgcag caggagcagc     4020

cagcagtgca ttcaccccac ttttgtaaac tgctctgcat ataaaccaag ggcagaatgt     4080

ttcaccctga tcttatggga ggaatcaaac tcccaaaata gtgtgtatat atgtaataaa     4140

cagcgtcacg taaatacata tatgcagtgc ttgttgtcca aatagaaatg aaaataagtg     4200

gaagagagag gaagaagtca aaccatatga aactgaaaaa atatgacgta cgaaatggac     4260

aaaaagcttt ttctgaaacc aactttttac ttccatcatc cttttttagc ctgttgcttc     4320

agagagacac aaagtgaaca cactggtgtg aatgtcgctc tctgtgtgct tgtgtttgta     4380

atgaaagtct acagccaatt ttacttgtct accaccgtgt tgtgctcaaa gagacactac     4440

ttgagtgaag atttcttctt tccctgtacc agctgttaca gtgttacgtt gtgtttaaaa     4500

tgtgtatggt ttattgcaat ctgaacagag ctatgggttt ctaccataag tcaggttgtt     4560

tgttccctaa cctgtctctc atagcaaagt cacttttata acagtttacc actatgcttg     4620

attataatgt gaaaggcgga attctgagtg tgttaagatg gtattaatca tgtcggtgtc     4680

atgtcactaa gtttaatgct gctgttttta aaaaaaaaaa aaagtttttt taaaaagcca     4740

atctatgtac taaattgctt ccaggtaatt tttgatttcc taaagtgcac tgaggttatc     4800

tggaagattg ggtgtatttt ttggtgactg ctgcattcat cagcaatgaa cagtttccac     4860

tgtatagtcc taggggtcag ggggtggggg tttcattttc cattcctcag cacagagcag     4920

aaatgataga tttttattgt ttggagtaac gttggtatgc agcagaggaa cgtaaacatt     4980

tggtcttggt tcagaagcct aacagattgc tagacaagag aaaaaacttg aagaaaaaag     5040

aagcttaatt tcatgcttca taagtagcat ttatatttat agcaccaatg tacattttga     5100

aactttcttt caggggtggg agttatgggg aaggggtggg tgtgaagggg tagatgaaag     5160

ctttaattta gaaagaaagt tcaagtaaag gaaattattt tgattaaata tattttattt     5220

gatctgggta tttttggacc acattattaa attaattgtt aagctgcagt tgagttgttc     5280

aagtgagagt tttgataagc cacttatggg ccgcgttgtg aatcacttgc cagttgtact     5340

ttatggagct tattttatga tttaaaatac tgtactgtac ataggaggta tgttaccttc     5400

tccttatttg tatgtttacc atatactttg atatttgaaa tgttatgtac tggaaaggcc     5460

acttatattt ctagaacaga ttggatttta tgcaaccttt tttccttgaa ttaacagc       5518


<210> 488
<211> 1262
<212> DNA
<213> Homo sapiens

<400> 488
cgtgtgtagt tggcatctcc gcgcgtccgg acacccgatc ccagcatccc tgcctgcagg       60

actgttcgtg ttcagctcgc gtcctgcagc tgtccgaggt gctccagttg gaggctgagg      120

ttcccgggct ctgtagctga gtgggcggcg gcaccggcgg agatgcctgg gaagaaggcg      180

cgcaagaacg ctcaaccgag ccccgcgcgg gctccagcag gaccggcggg tacggcgggt      240

acggcgaggg accaagccgg atttgcgatt gggatgcagc tgcgtttcac caggggcaaa      300

aagctccttt cctcctctct ttcctcctcg ccacttgccc ttccccgggg ccacgaggaa      360

caagtgcaag tagctggaag tcgagtgtgc tactcaactc aggagatttg gagacaaact      420

gaacttccgg cagaaacttc tgaatctgat atccaaactc ttctgctcag gaacctgact      480

gcatcaaaaa cttgcatgag gggactcctt caaaagagtt ttctcaggag gtgcacgttt      540

catcaatttg aagaaagact gcattgtaat tgagaggaat gtgaaggtgc attcatgggt      600

gcccttggaa acggaagatg gaatacatca aagtgaattt ctgttcaagt tttcccagat      660

tatcattctt tgggatgaga gaacattata aaaccacttt gtttatttta aagcaagaat      720

ggaagaccct tgaaaataaa gaagtaatta ttgacacatt tcttttttac ttagagaatc      780

gttctagtgt ttttgccgaa gattaccgct ggcctactgt gaagggagat gacctgtgat      840

tagactgggc ggctggggag aaacagttca gtgcattgtt gttgttgctg tttttggtgt      900

tttgcttttc agtgccaact cagcacattg tatatgattc ggtttataca tattaccttg      960

ttataatgaa aaaactcatt ctgagaacac tgaaatgtta tactcagtgt tgatttcttc     1020

ggtcactaca caacgtaaaa tcatttgttt cttttgactc aaattgtatt gcttctgttc     1080

agatgatctt tcattcaatg tgttcctgtt gggcgttact agaaactatg gaaaactgga     1140

aaataacttt gaaaaaattg gataaagtat aggagggtta cttggggcca gtaaatcagt     1200

agactgaaca ttcaatataa taaaagaaca tggggatttt gtataaccag ggataataaa     1260

aa                                                                    1262


<210> 489
<211> 1421
<212> DNA
<213> Homo sapiens

<400> 489
aggcgggagg cgacgcctgc gcagtgcggt cgcggggctg tcgttgtccc gcgagccgcc       60

gaccaggcct cgaacgggat ggcagaggag gtgagcaccc tgatgaaggc cacggtcctg      120

atgcggcagc ctgggcgggt gcaggagatc gtgggcgccc tccgcaaggg cggcggagac      180

cggttacagg tgatttctga ttttgacatg accttgagca ggtttgcata taatggaaag      240

cgatgccctt cttcttacaa tattctggat aatagcaaga tcatcagtga ggagtgtcgg      300

aaagagctca cagcgctcct tcaccactat tacccaattg agatcgaccc acaccggacc      360

gtcaaggaga agctacctca tatggtggaa tggtggacca aagcacacaa tctcctatgt      420

cagcagaaga ttcagaagtt tcagatagcc caggtggtta gagagtccaa tgcaatgctc      480

agggagggat ataagacctt cttcaacaca ctctaccata acaacattcc ccttttcatc      540

ttttctgcgg gcattggtga tatcctggaa gaaattatcc gacagatgaa agtgttccac      600

cccaacatcc acatcgtgtc taactacatg gattttaatg aagatggttt tctccaggga      660

tttaagggcc agctcataca cacatacaac aagaacagct ctgcgtgtga gaactctggt      720

tacttccagc aacttgaggg caaaaccaat gtcatcctgc tgggagactc tatcggggac      780

ctcaccatgg ccgatggggt tcctggtgtg cagaacattc tcaaaattgg cttcctgaat      840

gacaaggtgg aggagcggcg ggagcgctac atggactcct atgacatcgt gctggagaag      900

gacgagactc tggatgtggt caacgggcta ctgcagcaca tcctgtgcca gggggtccag      960

ctggagatgc aaggcccctg aaggcgcagg ctccagcccg gcctgcaggc cgtggtgagg     1020

aggggcgcct ccccagagtc tgctcccccg tgaacacaga gcagaggcca gggtggccag     1080

cagtggctgg gtccttccgc gcccctccgt cctcctttcc ctgagcacct tcatcaccag     1140

aggcttgaag gaaccccgcc atgtggcagg gcacaggcac tgttcctggt gaaccttgga     1200

ccacagcatg tcagtgctct agggattgtc tactccaggg attttcttca aaatttttaa     1260

acatgggaag ttcaaacaaa tataatgtgt gaaacagatc aaaattttta aaatgaaaaa     1320

aaagctgctc tgattcaggg gatgtgggtg ggggtagaac ctggacctct tggccctggg     1380

ggcacatggg atgcttctag gaacacagtt tgagaaccac c                         1421


<210> 490
<211> 3844
<212> DNA
<213> Homo sapiens

<400> 490
agccattttg ttccgcccga ggagacccta agatggcggc gagggggacg gtgaaggttg       60

cctcccgccc gtccgggctc tgatcctccg tctccccgtc ccccggcggc cggcccatgg      120

cctggcggag gcccgaacca tggacctccg caccgccgtg tacaacgccg cccgtgatgg      180

caagctgcag ctgctccaga agctgctcag cggccggagc cgggaggaac tggacgagct      240

gacgggcgag gtggccggcg ggggaacgcc gctactcatc gccgcccgct acggccacct      300

ggacgtggtg gagtacctgg tggaccggtg cggcgcgagc gtggaggccg gtggctcggt      360

gcacttcgat ggcgagacca tcgagggcgc gccgccgctg tgggccgcct ccgcagccgg      420

ccacctggac gtggtgcgga gcctgctgcg ccgcggggcc tcggtgaacc gcaccacgcg      480

caccaactcc acgcctctcc gcgccgcctg cttcgacggc cacctggagg tggtgcgcta      540

cctggtcggc gagcaccagg ccgacctgga ggtggccaac cggcacggcc acacgtgcct      600

catgatctcg tgctacaagg gccaccgtga gatcgcccgc tacctgctgg agcagggcgc      660

ccaggtgaac cggcgcagcg ccaagggcaa cacggccctg catgactgcg ccgagtccgg      720

cagcctggag atcctgcagc tgctgctggg gtgcaaggcc cgcatggaac gtgacggcta      780

cggcatgacc ccgctgctcg cggccagcgt gacgggccac accaacatcg tggagtacct      840

catccaggag cagcccggcc aggagcaggt cgcaggggga gaggctcagc ctgggctgcc      900

ccaagaagac ccctccacca gccaggggtg tgcgcagcct cagggggctc cgtgctgcag      960

ctcctcccca gaggaaccac tgaacgggga atcttacgaa agctgctgtc ccaccagccg     1020

ggaagctgcc gtggaagcct tggaattgct gggagctacg tatgtggata agaaacgaga     1080

tctgcttggg gcccttaaac actggaggcg ggccatggag ctgcgtcacc aggggggcga     1140

gtacctgccc aaaccggagc ccccacagct ggtcctggcc tatgactatt ccagggaggt     1200

caacaccacc gaggagctgg aggcgctgat caccgacccg gatgagatgc gcatgcaggc     1260

cctgttgatc cgggagcgca tcctcggtcc ctcgcacccg gacacttcct attacatccg     1320

ttacaggggt gccgtgtacg ccgactcggg caatttcgag cgctgcatcc gcttgtggaa     1380

gtacgccctg gacatgcaac agagcaacct ggagcctctg agccccatga ccgccagcag     1440

cttcctctcc ttcgcggaac tcttctccta cgtgcttcag gaccgggccg ccaaaggcag     1500

cctgggcacc cagatcggct ttgcagacct catgggggtt ctcaccaaag gggtccggga     1560

agtggaacgg gccctgcagc tgcccaggga gcccggagac tcagcccagt tcaccaaggc     1620

gctggccatc atcctccacc tgctctacct gctggagaaa gtggagtgca cccccagcca     1680

ggagcacctg aagcaccaga ccgtctaccg cctgctcaag tgcgcgccca ggggcaagaa     1740

cggcttcacc cctctgcaca tggctgtgga caaggacacc acaaacgtgg gccgctatcc     1800

cgtgggcaga ttcccctccc tgcacgtggt caaagtgctg ctcgactgcg gggccgaccc     1860

ggacagcagg gattttgaca acaacacccc gctacacata gcagcccaga acaactgccc     1920

ggccatcatg aatgccctga tcgaagcagg ggcccacatg gacgccacca atgccttcaa     1980

gaagacggcc tacgagctgc tggacgagaa gctgctggcc aggggtacca tgcagccctt     2040

caactacgtg accctgcagt gccttgcggc ccgggccctg gataagaaca agatccctta     2100

caagggcttc atcccggaag atctggaggc gttcatcgaa ctgcactgac ctgcccagaa     2160

cgcctgcacc ctcacctctc ccctctcctg ctgagatggg ggaaatccgg ctgcggcata     2220

gcagatgctc gttcttgcct ccttcaggca ccaatcagga gaagggttct gcctcccatc     2280

ccctctacct gcagacaggg tcggaggtgt tagcgagcct ttggtgctag aagcctgcgg     2340

ggtcatgtgc taagaggaca gtctttctcc gggagcccgc tcactcattc tgagttagga     2400

aaagacacaa gaccttcccc acatcctgtc tgcctgggtt agggaggcct ttgccttgtt     2460

acctagaggc ggagggactg aagccattgc gttccttccc tgctagaaac acaggaagaa     2520

gttgaggact gtctgccttc cctcgtccct ttacctggcc agataactcc agccgctgaa     2580

tacagtgtta ggactggggg ctcctgagat gagagtttga gattcaggga atgagaccac     2640

ctctcatttc ttccagcatg atcgcgccct gctcccgtgc caccgtagtc cctggcagac     2700

aggcagggct ctgcccaggg cagcctgcca cttgcatagc tttcggttgg tttggtgttc     2760

tgtttattta ataagtgggc aggttgcaag cgttgcacag aaattctgag attttactgc     2820

cttttttttt ttttttaaga aagttgtttg ttggactcca taagtgaatt tcaagcagtg     2880

aggattttgt ggtgcctgag atggccgagg gcacagggag tgagctgtat gtgtgaggaa     2940

tttggtgagc gagataaaag tccacggtgt caacccctaa aacatgggtg accgtacatt     3000

tttatacatc tccactctac ggccttttac aggctttccg attttacagg cctttccaag     3060

tttccattct ccttagagag agaactgtgc ttccaaacag aaatcaggag tgaccacaaa     3120

gcctgaaaac actttgccac ccagcaaaga actggcacaa ttggtttggg tctgcattgc     3180

catagtgccc gagttaaaac tgcaggccac tctgccttgc agtggcctct gatttcattg     3240

tgggtgcatc cacaggtggc ccgagctgtt ctttcagctg ctccaaggat tgagacccaa     3300

gtcatcatga aaaaggccca agtacagtct taatgcgata aatccactag ctaagacgtc     3360

gagtgccaag accagccttc cagccgaggt ttggacaaag tctcaggttc ccgtgactca     3420

gggtaaggtg ctggggctgc cagaggacct gccccagcaa gatttttgtc aagagcgaga     3480

ctccatcagc ccaggcagac gggagcaggt tcttggccag cgtagacagc agcaaacagc     3540

agcagggaag ccattctcac tgcatcctcc ctgcagtagc cacggccagg cccttaggag     3600

gagcagtgac cgggggtgtc cagaaatatc ctgtccctgg atggaaacta ggtctcgttt     3660

ggattttttt ttttttttgc cgtgttagga aattatttat taatttacaa gacaggtttt     3720

aactcagccg aggtgggaaa tggtgtccct gtccctccca aagcacagag cacagaaatg     3780

aggccgttta catggcgagt ctccgtgctg gtgtttaagt cattaaaaag atactcaaag     3840

agaa                                                                  3844


<210> 491
<211> 852
<212> DNA
<213> Homo sapiens

<400> 491
gtgacagagc gctttacgac agttgctttg aggcagtacc ggaggagaaa gatggcggct       60

accttactag ctgctcgggg agccgggcca gcaccggctt gggggccgga ggcgttcact      120

ccagactggg aaagccgaga agtttccact gggaccacta tcatggccgt gcagtttgac      180

gggggcgtgg ttctgggggc ggactccaga acaaccactg ggtcctacat cgccaatcga      240

gtgactgaca agctgacacc tattcacgac cgcattttct gctgtcgctc aggctcagct      300

gctgataccc aggcagtagc tgatgctgtc acctaccagc tcggtttcca cagcattgaa      360

ctgaatgagc ctccactggt ccacacagca gccagcctct ttaaggagat gtgttaccga      420

taccgggaag acctgatggc gggaatcatc atcgcaggct gggaccctca agaaggaggg      480

caggtgtact cagtgcctat ggggggtatg atggtaaggc agtcctttgc cattggaggc      540

tccgggagct cctacatcta tggctatgtt gatgctacct accgggaagg catgaccaag      600

gaagagtgtc tgcaattcac tgccaatgct ctcgctttgg ccatggagcg ggatggctcc      660

agtggaggag tgatccgcct ggcagccatt gcagagtcag gggtagagcg gcaagtactt      720

ttgggagacc agatacccaa attcgccgtt gccactttac cacccgcctg aatcctggga      780

ttctagtatg caataagaga tgccctgtac tgatgcaaaa tttaataaag tttgtcacag      840

agaatctttg ta                                                          852


<210> 492
<211> 1665
<212> DNA
<213> Homo sapiens

<400> 492
gttgcagcct gctgcgcgcc caggggtccc gcgggttttc gggcgcaggg tggcgcccgc       60

ggcaggcggc ggccatgaac ttctccgagg tattcaagct ctccagctta ctctgcaagt      120

tctccccgga cggcaagtac ctggcttcct gtgtccagta ccggttagtg gtccgggatg      180

tgaacaccct tcagatcctt cagctgtaca cgtgcctaga ccagatccag cacatcgagt      240

ggtcggcaga ctcgctcttc atcctgtgcg ccatgtacaa gcgagggctg gtgcaggtct      300

ggtctttaga gcagcccgaa tggcactgca aaatagacga gggctcagcc gggctggtgg      360

cctcgtgctg gagcccggac gggcgccaca ttctcaacac cacggaattc catctgcgga      420

taaccgtctg gtccttgtgc acaaaatccg tgtcttacat caaatacccg aaagcttgtc      480

tgcagggaat caccttcacc agggacggcc gctacatggc gctggcagaa cggcgcgact      540

gcaaagatta cgtgagcatc ttcgtctgca gtgattggca gctcctgcgg cattttgata      600

cggacaccca ggatctcaca gggattgagt gggccccaaa cggctgtgtg ctggcagtgt      660

gggacacctg cttggagtac aagattctgc tgtactcatt ggatggccgg ttgttgtcca      720

cgtacagcgc ttacgagtgg tccctgggca tcaagtctgt ggcctggagc cccagcagtc      780

agttcctggc agttgggagc tatgatggaa aggtgcgcat ccttaatcac gtgacttgga      840

aaatgatcac ggagtttggg catcctgcag ccattaatga tcccaagata gtggtgtata      900

aggaggccga gaagagccca cagctgggac tgggctgcct ctccttcccg ccgccccggg      960

ccggggccgg ccctctcccg agctcagaga gtaaatatga gatcgcctct gtcccagtct     1020

ccttacagac actgaaacct gttaccgaca gagcaaaccc gaaaatcggc ataggaatgc     1080

tggcatttag tcctgacagc tacttcctgg cgacaaggaa cgacaacatt cccaatgccg     1140

tctgggtctg ggacattcag aagctgaggc tgttcgcggt gctcgagcag ctgtccccag     1200

tgcgcgcatt tcagtgggac ccgcagcagc cgcggctggc catctgcacg ggaggcagca     1260

ggctctacct gtggtcccca gcgggctgca tgtcggtgca ggtgcctggg gaaggcgact     1320

ttgcagtgct ctctctgtgc tggcatttaa gcggagactc gatggccctc ctcagcaagg     1380

atcacttctg cctctgcttc ctggagacag aggcagtggt cggcacagcc tgcagacagc     1440

tgggcggcca cacgtagcag cggtgcacta acgtgtgcag aaacagggct actctgtgtt     1500

tccagtgtgg gaaaaaacac agcttcacca ggaggttctc cactgtggtg gtctggattc     1560

agtgattgat tctatttttc tatagcaaag catttttgta aatatgtatg gtataaaact     1620

gtagttttat tatttaaaat aaatacttgc tgatttatac aacta                     1665


<210> 493
<211> 1655
<212> DNA
<213> Homo sapiens

<400> 493
cctggaccag ggggacatct gagaagcatg atgttgagtg ccagacagct aggtctccaa       60

agttgggctc gttgctggag tctgccccct caaccgctga attcttgctg ggagtagtag      120

cagtttggga atgccatctg cagcatggag ctggggttga gcttggacca ccccaagacc      180

tggggtggat cttaagggtc agcttgagcc taggctctcg agtcctgaca tcatcctcta      240

ccgccacgct ttccagctgt cagccttggt ctccatctgg ttccttgagg gtgtggcctc      300

tgcgtcctgc tatcaccctt ccttgtctaa accttcccac ctgagtggag aggaacttgg      360

gggaaaatct ctaagcatgg gctcttcctg ctgtcctatg cttcctatcc cctagggtta      420

gtggtgcgtg ttgggtggtg gagcgaggga tcccttggag caaggttctt agagaacttt      480

gggtctgaaa gcagctcaaa ccttccaaag ccccaagctt ccctgtgcta ttagagcacc      540

tcctcctgga gagagcggct ctcgtggctg gggagttgga tgcaccaaac ctgtgtgcgg      600

ctggagaggg aggcttctgc cagaccctct cccgggcctg tcctgccacc caggcccctc      660

cccagtctca cactgagctc cagatcaggg aagggccgaa aaggacgatc agggcagccg      720

cagaaggggc gccctgcgtg ggacgggtcc gttgcgcgcc tggtaaccga gggggaaggg      780

aaggggcctc tggcgtgcgg ggcggtgtcg cgcaggtccc accccgcctg cccgcgccgc      840

ccattggtcc cgagcgcgat gacttggcgg gcggagcagg aaggaaaccg ctcccgagca      900

cggcggcggc gtcgtctccc ggcagtgcag ctgccgctac cgccgccctc tgcccgccgg      960

cccgtctgtc tacccccagc atgagcggcc tgcgcgtcta cagcacgtcg gtcaccggct     1020

cccgcgaaat caagtcccag cagagcgagg tgacccgaat cctggatggg aagcgcatcc     1080

aataccagct agtggacatc tcccaggaca acgccctgag ggatgagatg cgagccttgg     1140

caggcaaccc caaggccacc ccaccccaga ttgtcaacgg ggaccagtac tgtggggact     1200

atgagctctt cgtggaggct gtggaacaaa acacgctgca ggagttcctg aagctggctt     1260

gagtcaagcc tgtccagagt tcccctgctg gactccatca ccacactccc cccagccttc     1320

acctggccat gaaggacctt ttgaccaact ccctgtcatt cctaacctaa ccttagagtc     1380

cctcccccaa tgcaggccac ttctcctccc tcctctctaa atgtagtccc ctctcctcca     1440

tctaaaggca acattcctta cccattagtc tcagaaattg tcttaagcaa cagccccaaa     1500

tgctggctgc ccccagccaa gcattggggc cgccatcctg cctggcactg gctgatgggc     1560

acctctgttg gttccatcag ccagagctct gccaaaggcc ccgcagtccc tctcccagga     1620

ggaccctaga ggcaattaaa tgatgtcctg ttcca                                1655


<210> 494
<211> 5897
<212> DNA
<213> Homo sapiens

<400> 494
gcccccgccg ggcggctgag ggggcggagc ctcagccgct gtggatgggg agtggaggcg       60

gaggggagcg gagcccggag cgtcgtggaa agcattggac acatttccac catgctaatg      120

gcattttaaa tatatttggc aattttccca attttttact gaagaaaact gtaagtttat      180

acttgaggac tgaagtgtga ctctgccgat tatcaggctt tcaagatgaa tctggaaaaa      240

ctcagcaagc ctgaactcct gacactattt agtattcttg aaggagagct tgaagcaagg      300

gaccttgtta tagaagcctt aaaggcccaa cacagagata ctttcattga agaacgctat      360

ggaaaatata acatcagtga tcctttaatg gctctacaga gagattttga aacactgaag      420

gagaaaaatg atggcgaaaa gcagccagtc tgcacaaatc cactctctat tcttaaggtt      480

gtgatgaagc agtgcaagaa catgcaggag cgcatgctgt cccagctggc tgctgctgag      540

agcaggcacc gaaaggtgat cctagacctt gaggaagaaa ggcagcggca tgcacaggat      600

acggctgaag gagatgatgt cacctacatg ctagagaagg aaagagagag gctgactcaa      660

cagttggaat ttgaaaaatc ccaagtgaaa aagtttgaaa aagaacagaa gaagctctct      720

agtcagctgg aagaggagcg ctcccgccac aagcagctct catccatgct agtgcttgag      780

tgcaagaaag ccaccaacaa ggcagccgag gaaggacaga aggcaggaga gctgagcctg      840

aaattggaga aggagaagag ccgggtgagt aaactggaag aagagttggc agctgagaga      900

aagagaggct tgcagactga ggcccaggta gagaagcagt tatcagagtt tgacatcgaa      960

agggaacaac tgagagcaaa actgaaccga gaagagaacc ggaccaaaac cctgaaagaa     1020

gaaatggaaa gtttaaagaa gatagtgaag gacctagagg cttcccacca gcacagtagc     1080

cctaatgagc aattgaagaa accagtaacc gtgtccaaag gcacagcaac tgagcctctc     1140

atgctaatgt ctgtgttttg ccaaacagag agttttccag cagaaagaac ccatgggagc     1200

aacatagcca agatgacaaa cactgggctg cctggtcctg ccactcctgc ttactcatat     1260

gcaaaaacca atggccattg tgacccagag atacaaacta ccagggagct gactgcaggc     1320

aacaatgtag aaaaccaggt gcctccacgg gaaaaatctg tggcattggc ccaagagaaa     1380

ccagtggaga atggtgggtg tcctgtgggg attgagactc cagtcccaat gcccagtccc     1440

ctctcttcca gtgggagctc actgtctccc agcagcactg cctcctcctc tctaacatcc     1500

tctccttgct cttcgccggt actcactaag cgtttattgg ggtcatcagc tagcagccct     1560

ggctaccagt catcgtacca agtagggatc aaccaacggt tccatgcagc tcgccacaaa     1620

tttcagtccc aagcagatca ggaccaacaa gccagtggcc tacagagccc tccatccagg     1680

gatttatccc ccaccctcat agacaactct gccgccaagc agctggcccg aaacacagtc     1740

actcaggtgc tctccagatt cactagccaa caagggccaa tcaagccagt ctctcccaac     1800

agctctccct ttggcacaga ctatcgaaat ctagccaaca ctgccaatcc aagaggtgac     1860

acaagccatt cacctactcc agggaaagtg tccagtcccc tgagccccct gtctccagga     1920

atcaagtccc caaccatccc cagagctgag agaggaaacc ctccacccat cccacccaag     1980

aaacctggcc tcaccccttc tccatctgct accactccat tgaccaaaac tcattcccag     2040

gcagcctctt tgaccactgc agaagacctt gccagcagct gctcttccaa tactgttgta     2100

gcaaatggta aggatgttga gttacttttg cctaccagca gctagtccct aggagggagt     2160

ctccacgttt gacattccat cagatttcgt ccaaaagctc agtcagactt ctgagtcaga     2220

ttatgttatt tattttgata gtagctgaaa ccatctgtat aatacattta gtatatttca     2280

ccattttgta tttttttaag tagaaactga gtagtttgga tttttatggc tcacatcttt     2340

ttactgaagc cagaaaggca cctcaaagat gtctcaagct cagcagtcac cgtcatgttg     2400

tgatgaagaa agcgaatcac caggtggtga tttgctatct atttgagaac tagaatcact     2460

caacactcat tttgaattat gcagaagtgg ttcatgcaga tttttattcc agatgaacat     2520

gttttaaaag tgcctgaaat atgactgcca tatgaatgtg attctgcagc aaaaaacaca     2580

aaatagatca tttaattaca gaaaatgaga tcctctgtga attctgaatg ttaaaaacca     2640

acactgcttt taatcctctt ttaatgtttt aatacaagct ttgtgttctg aaacaaggct     2700

gcataagtag aatgggaatc cttctaaagg tgggtgtgaa ctcaccacaa gctgagcttt     2760

atagagccct tgagaaaccc tcctgagcac taagcagttg gggtgctgat tttcttgtac     2820

ttttgaaaaa ttaagtcact cccagtttcc tgcataagtt cttgaacaga atgaaatcac     2880

atctccattc aaaaaatgtc tcaagcatct actgttgtgt aaggaacttc tgattctgat     2940

tgctgttact tgaataggaa atggttactc attctgtata aaagttttgc aagagaatga     3000

attttttatt ctgtaatcaa aaagcaataa cttgaaattc actctgtaat attataggtc     3060

agtcagaatt atacaagttt taccaaattg ttacacttat tctccaagct gccagaacct     3120

ggtatctgta tctgtaaaac caaattaact tttgcttaaa tgggaagtat acatatatct     3180

gtatagatac attacccctt tacatgttta acatacacac acttaaacac ataaatacta     3240

gtgtgattat atctttggag tttgcaatat agcataaagg acaagtagaa ctgcacatta     3300

agattaccta ccgaagcaac tagatgtggc tgggacacaa tcaaaggagg aattttgtcc     3360

acaggaaggt gaggaaattc caaatgaagc ctagatcttc agtatcataa aaaggcagag     3420

ctggccaggc acagtggctc atgcctgtaa tcttatcact ttgggaggct gagatgggag     3480

gatctcttga gaccaggtgt tcaagaccag cctcatcaac atagtgagac cccatctcta     3540

ttaaaaaaat aaataggcag agctaaacta accccagtgt cacaaaactc aactggtcat     3600

ataaatgagt gaaacaggcc tctcacacaa gcgatgtaaa acagctggga gcagtgggag     3660

ctgtggcaaa ctaaagtgcc caagccgcat ttaaaaaggg catctgttca gctccatctg     3720

cttgctgcgg tgcaagaatg ctaaaccagg attaccagtt cttcacattt tttgaaatcc     3780

aaattttcat gagaaacatt ctcattttta aatatcaaga agtgatttta aaatgtttaa     3840

atggtgctgg ttaaacaaac acgtctgcag ctggatttag cttgcaagct gccaagttgc     3900

aacctctttc attctagaaa cttctgtcat tttcatcata gcaagtctat gcggacaaaa     3960

gcctccaaac tttccaactg tgtaggccag tacagctggc aaggttcata gaatataatg     4020

gctatccccc tctgccaaat aagactatcc acaacccagc tcagacacag tggttatatg     4080

attttgtgtc catacaggag aggccttggt gtcttcacat acattctctg agccaacatc     4140

tatccagcag ccctgacctc ctgctataat ttaagtctat ttccttttaa tctaataaga     4200

gttgatagta aaaaggcagg tgatggaaat cagtgtataa atcacaatgg agtatattgg     4260

caactccaca gcttatagtt tgataaaggc aaatacatga aaaataaaaa tgctactaat     4320

gccccaaggt gtctatcaaa atgatgtagg gggtatctta aactgtccaa ggcaatcatg     4380

cattgaactt tattcctatg cagagccaaa acgaatagtg ttgataaaat agctaaactt     4440

tctaaactgg agaggaggct acagtgccag agagttattg tctcttttgc tttaaatggt     4500

aatcttaaaa gttgcattgt gctcttcctt tgttttggga tagatatata tagagagaga     4560

tactataagg aagtttattt cttaggaagt gcactgaata atgtatttct tttacagtgt     4620

aatatggggg tggggatatg cgaaagaaat gtgtattttt gctagttgcc taccttctga     4680

gataaataag cacaatcttg caatggatcc aataacccag ttaggtatta tagattagta     4740

tttaagtttg ctgtagattg tgtgtgtgtg tgctaagtaa aagttccatg attcacaatt     4800

ttagtattaa cccatgttgc aaaagctgtt actggccaac agattgtaat gatgtgtacc     4860

atataacaca agcattaact aggcattaac gtttgtaaag ccaaatatac catgcagaag     4920

tcttcatttt tatagcagac tgcattaaaa caagttaaat cttgctgttt ggggggaaat     4980

agtcttgttt gtacaaagtg aaaaatggca caatttgggc atattttgtt gggaagaggg     5040

ggtggtgtag agggagcact tgactgtggc tttgacaaaa caaatgaagt caatgaccca     5100

tccaggttag actccataag gaactaagac attgattttc tttagagtct tagagctgga     5160

aaaagccttt acaataatcc agtctgtgat tttttaaacc ttttggtggt tctggacctt     5220

tttgagaatc ttagaaaagc catggagttt atccctagaa aaatgaatat gcctatatgc     5280

aaaatttgtt tgatggcttc ataggatcca aagaccctga agccatccat ggctcatgta     5340

tttctgctta agaaagcata atcttgttct gctctctcat tttacaaatg attaatgcat     5400

cccttttcaa ctactccagc gctgttgctg ctgcaatgtt agcaaatgca agccagagag     5460

aagcacttga aaatcctttg atgtctaaaa aatgttcaaa tagtgtggat gtttacatat     5520

ctgaagtttt cagcatttaa gcaaattaat gatcatttca acaaatacta gcatatccgg     5580

tttcccttaa tagcctgtca gcagtgctgc cttgtcaatt tgtgtgtgtg tgtgtgtatg     5640

tgtgtgtgtg tgtgaattca taaggagtgc ttctgatgct tagtccttga aatggaactt     5700

caactgtctt tcaaaacact ggcttcaaaa taggatgtgt tttcctaatg aatcagaagt     5760

gggcaatgag cattgttcca caggaataat ttttaattta atttctataa aactagttga     5820

gaaatgagag cctgtccacc caccatttgt gtatcagtgg ccaattcatt agtaaaaata     5880

aaggagggga aaggaga                                                    5897


<210> 495
<211> 3471
<212> DNA
<213> Homo sapiens

<400> 495
cagattacac ttggttgact actccggagc agccactaag agggatgaac aggcctgcgt       60

ggaaattgaa tgagattctt ggaagctcga agtctggctg tggccatggg agatacagta      120

gtggagcctg cccccttgaa gccaacttct gagcccactt ctggcccacc agggaataat      180

ggggggtccc tgctaagtgt catcacggag ggggtcgggg aactatcagt gattgaccct      240

gaggtggccc agaaggcctg ccaggaggtg ttggagaaag tcaagctttt gcatggaggc      300

gtggcagtct ctagcagagg caccccactg gagttggtca atggggatgg tgtggacagt      360

gagatccgtt gcctagatga tccacctgcc cagatcaggg aggaggaaga tgagatgggg      420

gccgctgtgg cctcaggcac agccaaagga gcaagaagac ggcggcagaa caactcagct      480

aaacagtctt ggctgctgag gctgtttgag tcaaaactgt ttgacatctc catggccatt      540

tcatacctgt ataactccaa ggagcctgga gtacaagcct acattggcaa ccggctcttc      600

tgctttcgca acgaggacgt ggacttctat ctgccccagt tgcttaacat gtacatccac      660

atggatgagg atgtgggtga tgccattaag ccctacatag tccaccgttg ccgccagagc      720

attaactttt ccctccagtg tgccctgttg cttggggcct attcttcaga catgcacatt      780

tccactcaac gacactcccg tgggaccaag ctacggaagc tgatcctctc agatgagcta      840

aagccagctc acaggaagag ggagctgccc tccttgagcc cggcccctga cacagggctg      900

tctccctcca aaaggactca ccagcgctct aagtcagatg ccactgccag cataagtctc      960

agcagcaacc tgaaacgaac agccagcaac cctaaagtgg agaatgagga tgaggagctc     1020

tcctccagca ccgagagtat tgataattca ttcagttccc ctgttcgact ggctcctgag     1080

agagaattca tcaagtccct gatggcgatc ggcaagcggc tggccacgct ccccaccaaa     1140

gagcagaaaa cacagaggct gatctcagag ctctccctgc tcaaccataa gctccctgcc     1200

cgagtctggc tgcccactgc tggctttgac caccacgtgg tccgtgtacc ccacacacag     1260

gctgttgtcc tcaactccaa ggacaaggct ccctacctga tttatgtgga agtccttgaa     1320

tgtgaaaact ttgacaccac cagtgtccct gcccggatcc ccgagaaccg aattcggagt     1380

acgaggtccg tagaaaactt gcccgaatgt ggtattaccc atgagcagcg agctggcagc     1440

ttcagcactg tgcccaacta tgacaacgat gatgaggcct ggtcggtgga tgacataggc     1500

gagctgcaag tggagctccc cgaagtgcat accaacagct gtgacaacat ctcccagttc     1560

tctgtggaca gcatcaccag ccaggagagc aaggagcctg tgttcattgc agcaggggac     1620

atccgccggc gcctttcgga acagctggct cataccccga cagccttcaa acgagaccca     1680

gaagatcctt ctgcagttgc tctcaaagag ccctggcagg agaaagtacg gcggatcaga     1740

gagggctccc cctacggcca tctccccaat tggcggctcc tgtcagtcat tgtcaagtgt     1800

ggggatgacc ttcggcaaga gcttctggcc tttcaggtgt tgaagcaact gcagtccatt     1860

tgggaacagg agcgagtgcc cctttggatc aagccataca agattcttgt gatttcggct     1920

gatagtggca tgattgaacc agtggtcaat gctgtgtcca tccatcaggt gaagaaacag     1980

tcacagctct ccttgctcga ttacttccta caggagcacg gcagttacac cactgaggca     2040

ttcctcagtg cacagcgcaa ttttgtgcaa agttgtgctg ggtactgctt ggtctgctac     2100

ctgctgcaag tcaaggacag acacaatggg aatatccttt tggacgcaga aggccacatc     2160

atccacatcg actttggctt catcctctcc agctcacccc gaaatctggg ctttgagacg     2220

tcagccttta agctgaccac agagtttgtg gatgtgatgg gcggcctgga tggcgacatg     2280

ttcaactact ataagatgct gatgctgcaa gggctgattg ccgctcggaa acacatggac     2340

aaggtggtgc agatcgtgga gatcatgcag caaggttctc agcttccttg cttccatggc     2400

tccagcacca ttcgaaacct caaagagagg ttccacatga gcatgactga ggagcagctg     2460

cagctgctgg tggagcagat ggtggatggc agtatgcggt ctatcaccac caaactctat     2520

gacggcttcc agtacctcac caacggcatc atgtgacacg ctcctcagcc caggagtggt     2580

ggggggtcca gggcaccctc cctagagggc ccttgtctga gaaaccccaa accaggaaac     2640

cccacctacc caaccatcca cccaagggaa atggaaggca agaaacacga aggatcatgt     2700

ggtaactgcg agagcttgct gaggggtggg agagccagct gtggggtcca gacttgttgg     2760

ggcttccctg cccctcctgg tctgtgtcag tattaccacc agactgactc caggactcac     2820

tgccctccag aaaacagagg tgacaaatgt gagggacact ggggcctttc ttctccttgt     2880

aggggtctct cagaggttct ttccacaggc catcctctta ttccgttctg gggcccagga     2940

agtggggaag agtaggttct cggtacttag gacttgatcc tgtggttggc cactggccat     3000

gctgctgccc agctctaccc ctcccaggga cctacccctc ccagggaccg acccctggcc     3060

caagctcccc ttgctggcgg gcgctgcgtg ggccctgcac ttgctgaggt tccccatcat     3120

gggcaaggaa gggaattccc acagccctcc agtgtactga gggtactggc ctagccatgt     3180

ggaattccct accctgactc cttccccaaa cccagggaaa agagctctca attttttatt     3240

tttaattttt gtttgaaata aagtccttag ttagccactt gtgtcatttc caggttttct     3300

gggggagtgc agggggagat gggtgatgag gtatgaacgg atgcctcagt gtccaagata     3360

caaaaggcac tacatagaag tttgcttttt ccctgcctgt cttggtcact accacctctt     3420

ccctgagaag ggcgggcctt ccatgttctc tcacccgctt caactccaca t              3471


<210> 496
<211> 6626
<212> DNA
<213> Homo sapiens

<400> 496
ggggggagtc ggcgtctctc tcccccgcgc cagctcccgt acacggagcc gcattccttg       60

gcccccccac ccccctccct cggggccccc ccgcccccct cgggaaaaaa atccaccccg      120

aatcactcga acccgaggga ggcttccttt cacccttggg gagacgagct ttcaacggtt      180

acctcttctt cgtctccccc caagcccccg tcccctcccc ctgctcccac ccccttctgg      240

cgccgggtgt aaggtccctt taaggcgacg gcgccttcct cgggtcagac taccggcggc      300

gacgaccaca ggagcatggc ggacaccgac ctgttcatgg aatgtgagga ggaggagttg      360

gagccatggc agaaaatcag tgatgtcatt gaggactctg tagttgaaga ttataattca      420

gtggataaaa ctaccacagt ttctgtgagc cagcagccag tctcggctcc agtgcccatc      480

gctgcccatg cttctgttgc tgggcacctc tctacatcca ccaccgttag tagcagcggg      540

gcacagaaca gcgacagtac aaagaagact cttgtcacac taattgccaa caacaatgct      600

ggcaatcctt tggtccagca aggtggacag ccactcatcc tgacccagaa tccagcccca      660

ggtctgggca caatggttac tcaaccagta ttgaggcctg ttcaggtcat gcagaatgcc      720

aatcatgtga ctagttcccc tgtggcctca caaccaatat ttatcactac gcagggattt      780

cctgtaagga atgtccggcc tgtacaaaat gcaatgaatc aggttgggat tgtgctgaac      840

gtacagcaag gccaaacggt tagaccaatt acactagttc cagccccagg tacccagttt      900

gttaagccga cagttggagt tccacaagtg ttctcccaga tgacccctgt gaggccaggc      960

tccacaatgc ctgtgaggcc caccaccaac accttcacca ccgtcatccc ggccactctt     1020

accattcgaa gcaccgtccc acagtcccag tcccagcaga ccaagtccac tcccagcact     1080

tctaccactc ccactgccac acagccaacc tcactggggc aactagctgt tcagtctcca     1140

ggccagtcaa accagaccac gaatcccaag ctagctccct ccttcccctc tccacctgca     1200

gtgagcattg ccagctttgt cactgtgaag cgacctggtg ttacaggcga aaatagcaat     1260

gaagtggcca aattggtgaa tacccttaac accatccctt ccctgggcca gagtcctggg     1320

ccagtggtgg tgtccaacaa cagctctgct catggctctc aaagaaccag cggacctgag     1380

tcttcaatga aagtgacctc ttccatccca gtatttgacc tccaggatgg tggacggaaa     1440

atatgtccac gatgtaatgc tcaatttcgt gttactgaag ctttgagagg tcacatgtgt     1500

tactgttgcc cagaaatggt tgaataccag aagaaaggaa agtccctgga ttcagaaccc     1560

agtgtcccat cagcagcaaa gcccccatcc cctgagaaaa cagctcctgt tgcttccaca     1620

ccctcttcta cacctattcc tgctctgtca ccgcctacca aagtaccaga accaaatgag     1680

aacgtgggcg atgccgtcca gaccaaactc attatgcttg tagatgactt ctactatgga     1740

cgggatggtg gcaaagtagc ccagctcaca aatttcccta aggtcgccac atctttccga     1800

tgcccacatt gtaccaaaag gctaaaaaac aatattcgat tcatgaacca tatgaaacac     1860

cacgtagaac tcgatcagca gaacggtgag gtagatggtc acactatctg ccagcactgt     1920

taccgccagt tttccactcc cttccagctt cagtgccact tggaaaatgt tcatagtccc     1980

tatgaatcta ctaccaagtg caagatctgt gaatgggcgt ttgaaagtga gccactattt     2040

ctccagcata tgaaggatac tcataagcct ggagagatgc cttatgtttg ccaggtgtgt     2100

caatatcgct cctcactcta ctctgaggta gatgtccatt ttcggatgat ccatgaggat     2160

acccggcatc tgctctgccc ttattgcctg aaggtcttca aaaatggcaa tgcattccaa     2220

cagcattaca tgaggcacca gaagagaaat gtttatcact gcaacaaatg ccggctgcag     2280

tttctctttg ccaaggacaa aattgaacac aagcttcaac accataaaac cttccgtaaa     2340

cccaagcagc tggagggctt gaaaccaggc accaaggtga caatccgggc ttcccgaggg     2400

cagccacgaa ctgttcctgt atcctctaat gatacacctc ccagcgcctt gcaggaggca     2460

gcaccgctga cctcctcaat ggaccctctg cctgtcttcc tttatccccc tgtccagcgc     2520

agcatccaga agagagctgt taggaaaatg agtgtcatgg gccggcagac atgcctggag     2580

tgcagcttcg agatcccaga cttccctaat catttcccta cttacgtaca ctgctctctg     2640

tgtcgctata gcacctgctg ttctcgagct tatgccaacc acatgatcaa caatcatgtt     2700

ccacggaaga gccccaagta tttggctttg tttaaaaatt ctgtgagtgg aatcaagctg     2760

gcctgcactt catgtacctt tgttacctct gtgggcgatg ctatggccaa gcatttggta     2820

ttcaacccct ctcacagatc cagcagcatc ctgccacggg gactcacttg gatagctcac     2880

tcaaggcatg gccagactcg tgaccgagtg catgaccgga acgtgaagaa tatgtaccct     2940

cctccttcct tccccactaa caaagctgcc actgtgaaat ctgcgggggc caccccagct     3000

gagcctgaag agctactaac tcccttagcc ccagcactcc catcaccagc ctcaactgca     3060

accccaccac caacccccac tcacccgcag gctttagccc ttccaccgct ggctacagag     3120

ggagccgaat gtctgaatgt tgatgatcag gatgaaggga gcccagtcac ccaagaacct     3180

gagctagcat caggtggtgg tggtagtggt ggagttggca aaaaggagca gctgtctgtg     3240

aagaagcttc gagtagtact gtttgctcta tgctgcaata cagaacaggc agctgaacac     3300

ttccgaaatc cccagcgacg tattcgccgt tggcttcgac gtttccaggc ctcccagggg     3360

gagaatctag agggcaaata tctgagcttt gaggcagaag agaaactggc tgagtgggtg     3420

ctaacccagc gcgaacaaca gctacctgta aatgaggaga ccttgttcca gaaggccacc     3480

aaaataggac gttctttgga aggggggttt aagatctcct atgagtgggc tgtgcgtttc     3540

atgctgcggc accacctgac tccccatgcc cggcgagctg tggcccacac cctacctaag     3600

gatgtagcag agaatgcagg actcttcatt gattttgtac aacggcagat tcacaaccag     3660

gacttaccct tgtctatgat tgtggctatt gatgagatct ctttgttcct ggatacagag     3720

gtgctgagca gtgatgatcg aaaggagaat gccctgcaga cagtgggcac aggggaacct     3780

tggtgtgatg tagtcctagc cattctggca gatggcactg tccttcccac cctggttttc     3840

tacagagggc agatggatca gcctgctaac atgccagact ccatattgct agaggcaaag     3900

gagagtggct acagtgatga cgagatcatg gagctgtggt caactcgagt gtggcagaag     3960

cacacagctt gccagcgcag caaaggcatg cttgtgatgg actgtcatcg cactcacttg     4020

tcagaagagg tactggctat gcttagtgcc tctagcactt tgcctgcagt ggtcccagca     4080

ggctgtagct ccaaaattca gccattagat gtatgcatca aaagaactgt caagaacttc     4140

ctgcataaaa aatggaagga acaggctcgg gaaatggcag atactgcatg tgattctgat     4200

gtcctgcttc agctggtgct tgtctggctg ggtgaagtgc taggtgtcat tggggactgt     4260

ccagagctag ttcagcgctc cttcctggtg gctagtgttc tgcctggccc cgatggcaac     4320

attaactcac ctacaagaaa tgctgacatg caggaggagc taattgcctc cctagaggag     4380

caactgaagc tgagtgggga acattctgag tcttccactc cacgacccag atcatctcct     4440

gaagagacaa ttgagcctga aagtcttcac cagctctttg agggtgaaag tgagaccgag     4500

tctttctatg gctttgaaga agctgaccta gatctgatgg agatttgagt gttggggtca     4560

tgagggggtg tggagtgagg gtgggaacat gtgagggagg gtaaaggggc ttagggaaaa     4620

gggggcatac caggtggggt atttggtttc tattttttaa ttttatacca ccactccccc     4680

ctgaagttga cttacacttc cctgtggatt tgtggattaa ttaggaaaac caatagtaat     4740

cacgtctgag ccaaggagct ggcccattgg tcattcactt ctgctaaaaa caggtttttg     4800

tgactttttt tttttttaaa tttaaatcac tgtgtttggt atttttctga caaaattaag     4860

aaaaagaaaa aaaattattt gtgggcaaat gttaaatttt tttgtttccc cttttacctc     4920

aattgtatca tagtactggg tttttttgtt tgttttattg tgtggccaat gtctttgggc     4980

atgatgctat ctaatcattg ttaatgtgag aacatttctg aagatgggaa agacaaatta     5040

tgtagctcac aaactggttt attatatata tggataaaaa acttttttca ttgtggtctt     5100

aacactttta tataaaaatg aaaatggaaa aaaagtccca ctgaactctc tcttccttct     5160

ccttttcttt ccttccctct ccagagatgt tggtttctac agcaacccta gatataaaat     5220

tgtggcttta aaaatgcatg aaaccacctt taattatcca gaatgaatag atttgtcttt     5280

tcctcaccac cttccctcca aaacatgaca taaacaatat tttttgcact tgtgatcctt     5340

ggcccctttc cccattctca acaccatcca tccctctgga caaaggatca tacaggtgtt     5400

attagcaagc aagagatact gaagcgatca aacagtttta gggtggaagc cattcccagt     5460

ttgagtcttc atcctgtaag cccccagggg cagtccctgc tttactgaac ttcatcctgt     5520

tagatggaga gcatgcctgt ttaagggatt actggtccta cagccaggag ctaattgttc     5580

aagaagtgtt gaactttaaa aagacaagac cacttgttga aatccagcgt gctctgtggc     5640

tttcccctat ttctcttaat acttagggaa gaatctgaca ggaagaagcg cacaggggtg     5700

tgcacaaaga aaatgacatg aatctttatt tttcactgcc agcttcaagg aaagaaaatt     5760

ttttctacaa tttgcatgag ggattttttt aattgtatgt actcatggtt gtaaaccaaa     5820

acgtactgta ccgtacagag aaaaggagca aaaaaccaag tcttctgttt atcctgaggc     5880

tttccacaat gttcccctcc tgtgagccaa ggaggcaaac tgcacaagct tgtaaatggt     5940

tcgtctttaa aatgtacata agtggaacat ttaataaaat gaggggaaat ggatttataa     6000

acttgttttt tttctaggtg accctgttta ataggctttc acagactggg gaatgctcaa     6060

gatgtgatgg gcctggtggt acaggtgtga catttgttac cacccatttc tcccacccca     6120

ccctgctttt ttgtttgttt gttttttcat cccccagcac actataatat agtgaactgg     6180

aaaagtccct tccagaaaca gcttggccag ctttgtgaac ctttgacatc tgaaaacaac     6240

caaggatcca tctgggcttc tcttccccag ctttttgcct gatgccattt tattgacaga     6300

caatggactt tgaagtcagc ctttgccttt gagaaagttc aagaactatg gttggtcacg     6360

tctatctaca acctaatcct actctttggt agtctctgca gcagccacag ccttagcaga     6420

gctggggttc ctgtcttctg cacacgattg actttcttga tgggtaattt tttttaagat     6480

tataccaaca gtggatcagc tgggttttgg ccaggaagtt gtctttgtgg actctgcctg     6540

catggcttag tagtagaagg aaattttttt ttggttttgt tttttataat tcagtttaat     6600

caataaacat gtatttattg actgtt                                          6626


<210> 497
<211> 1902
<212> DNA
<213> Homo sapiens

<400> 497
actcctcaca ccacttaaca gccacttgtt tcatcccacc tgggcattag gttgacttca       60

aagatgcctc agttactgca aaacattaat gggatcatcg aggccttcag gcgctatgca      120

aggacggagg gcaactgcac agcgctcacc cgaggggagc tgaaaagact cttggagcaa      180

gagtttgccg atgtgattgt gaaaccccac gatccagcaa ctgtggatga ggtcctgcgt      240

ctgctggatg aagaccacac agggactgtg gaattcaagg aattcctggt cttagtgttt      300

aaagttgccc aggcctgttt caagacactg agcgagagtg ctgagggagc ctgcggctct      360

caagagtctg gaagcctcca ctctggggcc tcgcaggagc tgggcgaagg acagagaagt      420

ggcactgaag tgggaagggc ggggaaaggg cagcattatg aggggagcag ccacagacag      480

agccagcagg gttccagagg gcagaacagg cctggggttc agacccaggg tcaggccact      540

ggctctgcgt gggtcagcag ctatgacagg caagctgagt cccagagcca ggaaagaata      600

agcccgcaga tacaactctc tgggcagaca gagcagaccc agaaagctgg agaaggcaag      660

aggaatcaga caacagagat gaggccagag agacagccac agaccaggga acaggacaga      720

gcccaccaga caggtgagac tgtgactgga tctggaactc agacccaggc aggtgccacc      780

cagactgtgg agcaggacag cagccaccag acaggaagaa ccagcaagca gacacaggag      840

gccaccaatg accagaacag agggactgag acccacggtc aaggcaggag ccagaccagc      900

caggctgtga caggaggaca tgctcagata caggcaggga cacacaccca gacacccacc      960

cagaccgtgg agcaggacag cagccaccag acaggaagca ccagcaccca gacacaggag     1020

tccaccaatg gccagaacag agggactgag atccacggtc aaggcaggag ccagaccagc     1080

caggctgtga caggaggaca cactcagata caggcagggt cacacaccga gactgtggag     1140

caggacagaa gccaaactgt aagccacgga ggggctagag aacagggaca gacccagacg     1200

cagccaggca gtggtcaaag atggatgcaa gtgagcaacc ctgaggcagg agagacagta     1260

ccgggaggac aggcccagac tggggcaagc actgagtcag gaaggcagga gtggagcagc     1320

actcacccaa ggcgctgtgt gacagaaggg cagggagaca gacagcccac agtggttggt     1380

gaggaatggg ttgatgacca ctcaagggag acagtgatcc tcaggctgga ccagggcaac     1440

ttgcatacca gtgtttcctc agcacagggc caggatgcag cccagtcaga agagaagcga     1500

ggcatcacag ctagagagct gtattcctac ttgagaagca ccaagccatg acttccccga     1560

ctccaatgtc cagtactgga agaagacagc tggagagagt ttggcttgtc ctgcatggcc     1620

aatccagtgg gtgcatccct ggacatcagc tcttcattat gcagcttccc ttttaggtct     1680

ttctcaatga gataatttct gcaaggagct ttctatcctg aactcttctt tcttacctgc     1740

tttgcggtgc agaccctctc aggagcagga agactcagag caagtcaccc ctttgtactg     1800

aattgtcctc atcttgtggg gggtttcagg actattttta tctctgacat ctctctattg     1860

ccccatctac cctaatgcat caataaaacc ttaagccact gg                        1902


<210> 498
<211> 2123
<212> DNA
<213> Homo sapiens

<400> 498
cctatccagg tgagaactgg ccactctaat ttacccggaa gcctttctgc aggagattca       60

aatatttgct aatgcttact gacaccttca ctggttagat cgaggcattc cccaccccat      120

ctgaaaaatg tttaccagaa gaaataactc ctcagtttgg gtaatccaaa agcctgcaaa      180

gtgacaatgg cccatctttc acagcaggcg tatcccaaaa cctgtcctca gctttaagaa      240

tccaatatga ccttcactct gctggagacc acagtcctct ggaaaggtga aagggctaac      300

cctactctaa agaagactcc agctaaatca gaggcctgac tgtctctaac acccatagct      360

tattgtgggt tagaactgct ccaaagtaaa acgtataatt gagtcctgtt gagttcacat      420

gtggaaggcc tttcctaacc acagatctcc taatagatga aaagactcat caattacaaa      480

aatatgtcat caatctagga caggtgcaaa ggcactccgt gcatatggaa acaagagtct      540

tcccctccca catgggagga aaattcagtt tcagctcagc tagggattta gtcttactaa      600

agacgcggga ggaagttctc cagcgagcag ctttccccaa cgtggaaagg accacgcaag      660

gacacctgag ctttccaaca gatgttcagc gccaggggat ccacagttct gggaggtgat      720

ctctgatgaa catgccatcg actccgctgg cacctaccac ggggacagcc acctgcagct      780

ggagcgcatc aacgtgtact acaacgaggc cagcggtgag acccccgtcc ttcccccacc      840

gccctcctgg gaacgcggcc ctcccctcgc tcatgccctc ccgccccacg caggtggcag      900

gtcagtgtgg ggccggaaac aactgggcca agggacacta caccgaaggc gcggagctga      960

tggagtcagt gatggacgtt gtcagaaagg aggctgagag ctgtgactgc ctgcagggtt     1020

tccagctgac ccactccctg ggtgggggga ctgggtctgg gatgggtacc cttctgctca     1080

gtaagatccg ggaggagtac ccagacagga tcataaacac attcagcatc ctgccctcgc     1140

ccaaggtgtc ggacaccgtg gtggagccct acaacgccac cctctcagtc caccagctca     1200

tagaaaacgc agatgagacc ttttgcatag ataacgaagc tctgtatgac atatgttcca     1260

agaccctaaa actgcccaca cccacctatg gtgacctgaa ccacctggtg tctgctacca     1320

tgagtggggt caccacgtgc ctgcgcttcc cgggccagct gaatgctgac ctgcggaagc     1380

tggccgtgaa catggtcccg tttccccggc tgcatttctt catgcccggc tttgccccac     1440

tgaccagccg gggcagccag cagtaccggg ccttgactgt ggctgagctt acccagcaga     1500

tgtttgatgc taagaacatg atggctgcct gtgacccccg tcacggccgc tacctaacgg     1560

cggctgccat tttcaggggt cgcatgccca tgagggaggt ggatgaacaa atgttcaaca     1620

ttcaagataa gaacagcagt tactttgctg actggctccc caacaacgta aaaacagccg     1680

tctgtgacat cccaccccgg gggctaaaaa tgtcagccac cttcattggg aataatacgg     1740

ccatccagga actcttcaag cgtgtctcag agcagtttac agcaatgttc aggcgcaagg     1800

ccttcctcca ctggtacacg ggcgagggca tggatgagat ggaattcacc gaggccgaga     1860

gcaacatgaa cgacctggtg tctgaatatc agcaatatca ggatgccacg gccgaggagg     1920

aggaggatga ggagtatgcc gaggaggagg tggcctagaa ctctcctttt ctaggtaaag     1980

gggggaagca gtgtggattc tttactgtgt tctgacagcc atgtgtcact atacgcttgt     2040

taatttgtgt cttcacatct cctgctgcgt tttaaagcat ttttatagta tgcggttttg     2100

actaataaag tattctcaca gca                                             2123


<210> 499
<211> 5045
<212> DNA
<213> Homo sapiens

<400> 499
attttctctg gcttgtgttt ctgacagtgt tagggcctcc taaagcttcc taggcatagg       60

ggtatgcctg gcttgaattt taaccaggga ctcagtccag attatgggga gacccgagga      120

aaagtgctgg gtagaagacc aaaaaacaaa gaccctcaga gtgaaaaggg cctctagaca      180

tcatcccttc caacatctcc cagtgcctgg agccctcctg cgccacgtgt gtcagatggc      240

cggagagcct ctgctcgaat acctctttga tggggagctc aactttttaa aagccaccag      300

ttgcatcgta agccaactct tgccattaga agatccttct tatgccagac ggaaaaccgc      360

tctctggaac tttctcccct ggctcattct gacccctgga gcaccagggc atacgtctgc      420

tctcttgctt acacggcagc ccttcagaca tttgtgacag ctctgtgtcc tgctaagatg      480

tctcttctct gagctgaaga tcccttgact ctttgggccc actgggtgtg agctgggggt      540

ctcagtcctc agggcctgtc ttttctctcc cccatcaccg ctcaaggtcg cacatgggca      600

gtgcagcaga cgtgcggttc tccctgggca caaccacaca cgcaccccca ggcgtgcatc      660

gccgctactc ggcattgagg gaagagtctg ccaaggactg ggagacttct ccactgcctg      720

ggatgctggc cccggcagct ggccctgcct ttgacagtga ccctgagatc tccgacgtgg      780

atgaggatga gccagggggt ctggtgggct ctgcggatgt tgtctccccc agcggccact      840

cagatgccca gaccctggcc atgatgctgc aggagcagct ggatgccatc aatgaggaaa      900

tcaggatgat tcaggaagag aaggagtcca cggagctccg cgcggaggag attgagacgc      960

gtgtaaccag tggcagcatg gaagccctaa acctgaagca gctgcgcaag cgtggttcca     1020

tccccacctc tctgacggcc ctgtccctgg ccagcgcgtc cccaccactc agcggccgct     1080

ccacacctaa gctcacctcc cgcagtgctg cccaggacct ggaccgaatg ggggtcatga     1140

ccctgcccag tgacttaaga aagcatagga ggaagctgct gtcgccagtg tctcgggaag     1200

agaaccgaga ggataaagcc accataaaat gtgagacttc tcctccttcc tcacccagga     1260

cgctgcggct agagaagctt ggccacccag ccctgagcca ggaagaaggc aagagtgcct     1320

tggaggatca gggcagcaac cccagcagca gcaacagcag ccaggactcc ctgcacaagg     1380

gcgccaagcg caagggcatc aagtcgtcca ttggccgcct gtttgggaag aaggagaagg     1440

gcaggctgat ccagctgagt cgggatggag ccacaggcca tgttctgcta acagactccg     1500

aattcagtat gcaggagcct atggtgcctg ccaagctggg gacccaggca gagaaggacc     1560

ggcggctaaa gaagaaacac cagctgcttg aagatgcccg caggaaagga atgccctttg     1620

cccagtggga tggtcctact gtggtctcct ggttggagct ctgggtgggg atgcctgcct     1680

ggtatgtggc agcctgccgg gccaacgtca agagtggtgc catcatgtcc gctctgtcgg     1740

acacagagat ccagcgggag atcggcatca gcaatgccct gcaccggctc aagctccgcc     1800

tggccattca ggagatggtg tcattgacca gcccctctgc cccacccacc tccaggactt     1860

cttctgggaa tgtctgggtc acccatgaag agatggaaac tctggaaaca tctactaaaa     1920

cagacagtga ggagggcagc tgggctcaga ccctggccta tggggacatg aaccatgagt     1980

ggattgggaa tgaatggcta cccagcctgg ggctcccgca gtaccgcagc tacttcatgg     2040

agtgcctggt ggacgcccgc atgctggacc acctcaccaa gaaggacctg cgggtccacc     2100

tgaagatggt ggacagcttc catcgaacca gtcttcagta tggcatcatg tgtctgaaga     2160

ggctgaatta tgaccggaag gagctggaga agaggcgaga ggagagccag catgagatca     2220

aggatgtgtt agtctggacc aacgaccagg tggttcattg ggtccagtct attgggctcc     2280

gggactacgc aggaaacctg catgagagtg gtgtgcatgg agccttgctg gccctggacg     2340

agaacttcga ccacaacaca ctggccctga tcctccagat ccccacacag aacacccagg     2400

cacgccaagt gatggaaaga gagttcaata acctgttggc cttgggcaca gaccggaagc     2460

tggatgacgg ggatgacaag gtgtttcgcc gcgcgccctc ctggaggaag cgcttccggc     2520

cgcgggagca ccacggtcgc ggcggcatgc tcagcgcttc cgcggagacc ctcccggcgg     2580

gcttccgtgt gtccaccctg gggaccctgc agcccccacc ggccccgcca aagaagatca     2640

tgcctgaagc tcactcccac tatctctacg gacacatgct ctccgccttc cgggactagc     2700

catggccccc agggctggct tcctccttct gggtttcaca ggctcctctg gccctgaccc     2760

ctcttgctcg ttccccttcc ttccgcagct cctagtctcg tccgtgactt tccggttgcc     2820

ctggatctca gaatatattc gtccaccccc tcggcacccc attaccccga gtcccaccgt     2880

gtgtccgttg taagtccggt ggatgtggct ggggtttcct ggtattgtgg aggcacccag     2940

gttgtccatg cttgggattc tgggggaagg agagaagggc agctcagggt ggatgtgaag     3000

ccacccttcc tcttctggac ccagcctggt ctgcactgca acctccacca ggaccaggat     3060

cctgggccac aggctgggat ggtccttcca agaaagggtc atttcagacg cagccctgct     3120

tgggctattc aatcttaggg tgtctatcca cgtctggctg tgccaaatgg tctggcagct     3180

ggttttggca tccccagcat caccactctc ccaacccatc accgtgactg cagttcctgc     3240

ccccattctc ttggggtcag ggaggggctg ggaagggcta ctgaaggccc cattctccca     3300

caggatggtg aggctgggag gaggaagact gaggtagaga ttccaggccc tggcataagc     3360

tgaatcccaa atttgagttt gggaagaacc agagagaaat ggatccctga gctctgagcc     3420

aagggtgagg atggggaaac tctaagctcc cacctaataa gaagcatagg cagaccagcc     3480

agagggagag ccaatggcct ctggtagcct taagcccaaa gggcagtggg aatgtcccct     3540

gccccaacca tcgggtggag ctcctgctgg gctatgggga agggaggttg tgcggatctt     3600

gactctaggg cagaacagat ctaaccatgc attgctagct ctgctcccag catcccttcc     3660

ccttctctcc tcctctgcct cacttcttta gtaatcccaa ccctataaaa atgaacctaa     3720

tgggtggatt gaatatacat tgagcccaaa gtcaagtttg gggaaaaggc agactaaggc     3780

ctcctttctc tgacctccca ggaagaaaat agcttctcct acagtgattc atgtcccagg     3840

tccaggaaat ccaatgttgg tgaaggcagc cactctcttg cttgtcccca aatcacctaa     3900

ccctcatcca gggctatttt ggtgggcagg gactgcctcc tcccggaatt cctaagatcc     3960

gcccagctgc caccattttc attgctttcc ccagcagcat gatgggaacc caagctgagg     4020

gatacaggtc ctgatttggt aggaatatta ttcccaagaa atacccgctc ctcacctact     4080

ccctcatcct accaaggtgc ctgaaaatgt tcaagactta tgttcagggt gggatgatgg     4140

aaccgagggc ttcatcaaag tgagaggaaa ggaaaagcat ctggcatgtg tttcttggat     4200

aggggccagt gcagtgccat cctacaggtg gctggagcag ctgctttgca acctgatcac     4260

cttgagttct gagcagggac taggcttgca ggtgagataa tgggccaggg cacccagtcc     4320

agaaggagca atggcacctg ggcagtgcca gggcttaaag cccgctgctc cttttcggta     4380

gaggagaggc ccatcactgg tgtggtgggg tgggctctcc cttaggcttg ggcaaggcag     4440

ccacctgccc ttgctctccc ttagtgttcc ctggcctccc tgccatcagg ttgctgggag     4500

tggagatgga gggattattg agcagaaaat gagttggatg gagataaaca gctcccatcc     4560

ctgggtaatg gatggtaaga tgatggagat tcctaagatt ggtggagttg ggcaatgcat     4620

agccatctga ctccttcagg gtgctcttga tgggctggct gtaagggaga ctcagtccca     4680

gcctctcccc tctacaactc ctgccactgt tggccatgtc gtaaggcagc agctgtgcca     4740

ggatagctgg gtccattcag agcaccttga gaagtgttgc agggaggtgt taagaagaga     4800

actctgtgca aacagtgatg gaaggctgtt gtcttggtgt atcccttgcc tcatagtcaa     4860

tatatttttt ttttggcgag tcaccagtga cccgagccct ccacaccagc ctcctgtatc     4920

tcatcaggtc ccttctcagt actgtatttg ctcagtgcat caggaatggg tgtatgggtg     4980

tgtgtgggtg ggtgtgagtg tgggtgtgta cgtaccaata aacaacctgg ttttaagaca     5040

atgta                                                                 5045


<210> 500
<211> 2484
<212> DNA
<213> Homo sapiens

<400> 500
gacgagccaa ggaaaaaaag tacaagtgtg gctgcaaagt ttgcccctct tgttaccctc       60

aggcaaatga ttgatttaga aaggccccag gggctatttt ttgcaggaac ggtcactccc      120

taaatccagg cagggaaagg gaggagtctg agccgagtca cgccccttct cctgtaaact      180

tgggtcgcct ctagcttagc gagcgctgga gtttgaagag cgggcagtgg ctgcacacgc      240

caaactttcc ctatggcttc ggtgaccagg gccgtgtttg gagagctgcc ctcgggagga      300

gggacagtgg agaagttcca gctgcagtca gacctcttga gagtggacat catctcctgg      360

ggctgcacga tcacagccct agaggtcaaa gacaggcagg ggagagcctc ggacgtggtg      420

cttggcttcg ccgagttgga aggatacctc caaaagcagc catactttgg agcagttatt      480

gggagggtgg ccaaccgaat cgccaaagga accttcaagg tggatgggaa ggagtatcac      540

ctggccatta acaaggaacc caacagtctg catggaggag tcagagggtt tgataaagtg      600

ctctggaccc ctcgggtgct gtcaaatggc gtccagttct cgcgcatcag tccagatggt      660

gaagaaggct accccggaga gttaaaagtc tgggtgacat acaccctgga tggcggagag      720

ctcatagtca actacagagc acaagccagt caggccacac cagtcaacct gaccaaccat      780

tcttacttca acctggcagg ccaggcttcc ccaaatataa atgaccatga agtcaccata      840

gaagcggata cttatttgcc tgtggatgaa accctgattc ctacaggaga agttgcccca      900

gtgcaaggca ctgcattcga cctgagaaag ccagtggagc ttggaaaaca cctgcaggac      960

ttccatctca atggttttga ccacaatttc tgtctgaagg gatctaaaga aaagcatttt     1020

tgtgcaaggg tgcatcatgc tgcaagcggg cgggtactag aagtatacac cacccagccc     1080

ggggtccagt tttacacggg caacttcctg gatggcacat taaagggcaa gaatggagct     1140

gtctatccca agcactccgg tttctgcctg gagactcaga actggcctga tgcagtcaat     1200

cagccccgct tccctcctgt gctgctgagg cctggtgagg agtatgacca caccacctgg     1260

ttcaagtttt ctgtggctta aggaagtgtg aagatatgat ccagtccagg gctaggctca     1320

gccacctgtc tcctgtccag aaaaaaggtg aagattaaga agctttcaga atgattctat     1380

ggattaaaat catacaaatg gtggctgttc tgagaatcag tctgggtatt gatttccttt     1440

tccagtgact ggctccaggc catgtctaat gaccagctcg attccctgtg cagttcagag     1500

ggcaagtgaa cccaaccaac aatgtcgtca tctaagccct gaccctagcc agggactccc     1560

atgctgctgt tggctccatc tctccacact gcctctttct tttcaacttt ttgcccttcc     1620

tttctttaaa gctattctca cattgctttt atttcctcct ccttcacctc caaccactgt     1680

cagcagcact ctggagtttt caaatgtcac attagcctca ccctgcatgc taggagatgg     1740

acctgtctct atacagcagt agatgattga taagtgagga aactgaggct tacagaggtt     1800

gaagaccaac aagctaataa ataaaaagtt gaggccgggc acggtggctc acgcctgtaa     1860

tcccagcact ttggaaggcc gaggcaggcg gatcacgagg tcaggagatc gagaccatcc     1920

tggctaacac ggtgaaaccc cgtctctaca taaaaaatta gctgggtgtg gtagcacgca     1980

cctgtagtcc cagctacttg ggaggctgaa gcaggagaat cgcttgaacc tgggaggtgg     2040

aggttgcagt gagccgagat catgccactg cactgggcaa cagagcaaaa ctcgatctca     2100

aaaaaaaaaa aaaaaaaaag gaaaaaaaag cagctctctc tctcgggaga gggaggggac     2160

ttccgagagg aaaaggcctg caagagcctt tgggttaact gagaaagcac agcccggcca     2220

acgcttggga agaaagacag gcaagcactg gaaacaggag ctattagggt gaggagagag     2280

ccttgccttt cacagcacag tgaggatgac attgcaccag ggacagagat tgtatgtgac     2340

aaggctgggg ctccttcttt cctagacaat caaagtatca gtgatgggtt ttggttggtg     2400

attttgaaaa aaaaaaaaaa aagtatgtta tactagtgta tgctgtactg aattgaaata     2460

aaaccaaaat ctgcatcttc agaa                                            2484


<210> 501
<211> 5242
<212> DNA
<213> Homo sapiens

<400> 501
aggcagagag agtcgggtta caagatggcg gatctgtagt agttaccgcg gcggcgggag       60

agcaagcgag ccctgggggg caaagagacg ggagagtggg tgtatgcgcg ggtgaagtga      120

gaggtaacgg ggctccgggc ggagaggcct cagtggctct tgtcacccct tctcgcggct      180

gaacctttgg agccatggtg aattcgggcc tctccgaagc cgccgccgcc gccaccgcca      240

ctactgcctt taccgtctcc taagagtgag gagcgcggac gaggtaagcg aggaggcggc      300

ggctagagcg gtggagacag cagccaccat gtcggatacg cggcggcgag tgaaggtcta      360

taccctgaac gaagaccggc aatgggacga ccgaggcacc gggcacgtct cctccactta      420

cgtggaggag ctcaagggga tgtcgctgct ggttcgggca gagtccgacg gatcactact      480

cttggaatca aagataaatc caaatactgc atatcagaaa caacaggata cattaattgt      540

ttggtcagaa gcagagaact atgatttggc tctgagtttt caggagaaag ctggctgtga      600

tgagatctgg gaaaaaattt gtcaggttca aggtaaagac ccatcagtgg aagtcacaca      660

ggacctcatt gatgaatctg aagaagaacg atttgaagaa atgcctgaaa ctagtcatct      720

gattgacctg cccacatgtg aactcaataa acttgaagag attgctgact tagttacctc      780

agtgctctcc tcacctatcc gtagggaaaa gctggctctc gccttggaaa atgaaggcta      840

tattaaaaaa ctattgcagc tgttccaagc ttgcgagaac ctagaaaaca ctgaaggctt      900

acaccatttg tatgaaatta ttagaggaat cttattccta aataaggcaa ctctttttga      960

ggtaatgttt tctgatgagt gtatcatgga tgtcgtggga tgccttgaat atgaccctgc     1020

tttggctcag ccaaaaagac atagagaatt cttgaccaaa actgcaaagt tcaaggaagt     1080

tataccaata acagactctg aactaaggca aaaaatacat cagacttaca gggtacagta     1140

cattcaggac atcattttgc ccacaccatc tgtttttgaa gagaattttc tttctactct     1200

tacgtctttt attttcttca acaaagttga gatagtcagc atgttgcagg aagatgagaa     1260

gtttttgtct gaagtttttg cacaattaac agatgaggct acagatgatg ataaacggcg     1320

tgaattggtt aattttttca aggagttttg tgcattttct cagacattac aacctcaaaa     1380

cagggatgca tttttcaaaa cattggcaaa attgggaatt cttcctgctc ttgaaattgt     1440

aatgggcatg gatgatttgc aagtcagatc agctgctaca gatatatttt cttatctagt     1500

agaatttagt ccatctatgg tccgagagtt tgtaatgcaa gaagctcagc agagtgatga     1560

cgatattctt cttattaatg tggtaattga acaaatgatc tgtgatactg atcctgagct     1620

aggaggcgct gttcagttaa tgggacttct tcgtactcta attgatccag agaacatgct     1680

ggctacaact aataaaaccg aaaaaagtga atttctaaat tttttctaca accattgtat     1740

gcatgttctc acagcaccac ttttgaccaa tacttcagaa gacaaatgtg aaaaggataa     1800

tatagttgga tcaaacaaaa acaacacaat ttgtcccggt gcccttcgct ttatgaggcg     1860

gataattgga cttaaagatg aattttataa tcgttacatc accaagggaa atctttttga     1920

gccagttata aatgcacttc tggataatgg aactcggtat aatctgttga attcagctgt     1980

tattgagttg tttgaattta taagagtgga agatatcaag tctcttactg cccatatagt     2040

tgaaaacttt tataaagcac ttgaatcgat tgaatatgtt cagacattca aaggattgaa     2100

gactaaatat gagcaagaaa aagacagaca aaatcagaaa ctgaacagtg taccatctat     2160

attgcgtagt aacagatttc gcagagatgc aaaagccttg gaagaggatg aagaaatgtg     2220

gtttaatgaa gatgaagaag aggaaggaaa agcagttgtg gcaccagtgg aaaaacctaa     2280

gccagaagat gattttccag ataattatga aaagtttatg gagactaaaa aagcaaaaga     2340

aagtgaagac aaggaaaacc ttcccaaaag gacatctcct ggtggcttca aatttacttt     2400

ctcccactct gccagtgctg ctaatggaac aaacagtaaa tctgtagtgg ctcagatacc     2460

accagcaact tctaatggat cctcttccaa aaccacaaac ttgcctacgt cagtaacagc     2520

caccaaggga agtttggttg gcttagtgga ttatccagat gatgaagagg aagatgaaga     2580

agaagaatcg tcccccagga aaagacctcg tcttggctca taaaatattt attaggggac     2640

cctcaacatg tggtcttaca atgctgcaac tgttcagtga gctgaaaatc tgaatcagaa     2700

agctttctca attgaactta taaaatatac aaggagtagc aaaagacagt atatcagcta     2760

agagagttta gttctaataa aaatcaggct tcccaggaac ttgattgctt gctagtaatt     2820

aaggggtttg ccttttaggc tgtcaaaaca aacattagta accagaacct gggagacagc     2880

ttctcagcaa ggaaaagtca caggtttggg gacggtttag gggaggggaa aaggttgata     2940

taataatgca gggttgctcc tcggggtgtc gatctagaaa caattttaca gaacttcagt     3000

tgtaaactca ataacattac ttgtataatg gtgctggcca tgttgttgtt ttaatcagtt     3060

gcctcttttt aaaagaaatt tttatggaaa acacattcaa ctatcattaa aaaaatgaag     3120

ttaagctgtt gggaccattt ctttaagatt taacaaaagt tcagcctttt aggtagttga     3180

agggaagtac accccgtatt cagcacatgt tgagttttct acaccaggaa ttttcaatat     3240

gtatattgat gaaaacaagc tcaattcaaa ctggacagtt ttaagataat gttaaaatca     3300

gcacttttag agacaacgaa ggccaagaat cagtacagta gtattccaaa atgattttct     3360

ctagaaattt gaaagtagat cgaacagaat gttgtcaacc gcctaccagt acaatctttt     3420

gtggaagata ctttgaaatc actttctact ttgttagtaa agttctgtct ttccagagct     3480

gcaagtttta aagtgttact tatacagacc aaccaagaat agtgctgaat taagtggcat     3540

ttagtatcta gaagccattt tgatccaaga agctacttaa gtgtcaaagt cagcatgcag     3600

cacatgtagc ttttctgtaa acaagggtgt gatatgaaag ctgctttttt aagaagagta     3660

aaagcacatt ccatatacgt aagtgaattt taaaaataaa ttgaggcaaa cagttaagtt     3720

ttatttttag agcaacaagt taactgtaaa tattttaatg ttagtttgct catctatgat     3780

ctgagatcat gccgaagtga gaaaaatctc cccaaaatac aatttaatgc attgggaaaa     3840

aaaaacttta acagtaattc cagccacaat ctttagatca cccttgtaat gtgttacggg     3900

tccatttttc ctggaatcgt ttaatctaaa gcagtttccc ctgttttgga gattttgtag     3960

ttaattttaa ttttggctat tgtttggaaa agatgagctg tctgtgtaga tatgaagtat     4020

agttttttcc ataaaacaga tgtttatttt gtattaaaaa ataccactgt acttgtttta     4080

caccatttgt atacatgtgg tgatattaat gctaaactgt aaaattcagg aattaaaatg     4140

tgaccctgta attccataat tgatgtttgt gtttggtttg ttgtaaatat aaattaactc     4200

cattttgaga tatgtcaatt ttacagtatc ttttaaaagc caataaaatt atccataaat     4260

atttattata aactgctaga tcatacccca attttaatga aataattcta aacaaatgcg     4320

ggtcaatggc actttatcag tgactactta tagaaggtaa gccttgggga aatcatagca     4380

tcacagtatg gagcttttct caccttttca attaaaggtg tacatatagt aagaaagaaa     4440

gaccttccac ctcataaggc aggtgactca ggatatttta aactaagatc agtaaagttc     4500

ccatccactt tctttgaatc atcaaatttt atcgagaccc atctctcagc ttttagtaaa     4560

tttcttctta aaataagccc acatgtaaaa cactttccta gttacttttt gtttgtttgt     4620

ttgagtctcg ctctgttgcc caggctggag tgtagttgca cgatttcggc ttattgcaac     4680

atccgccacc tgggttcaag caattctctg cctcagcctg agtagctggg attacaggtg     4740

cccgtcacca tgccaggcta atttttgtat tttcagtaga gacggggttt caccatcttg     4800

gccaggctgg tcttaaactc ctgacctcac aatccacccg cctcagcctc cctatctctg     4860

tatcttatga agacttcctt tttctttctg aagagctgcc ataagtctta aacatttaaa     4920

tcatcagaac cttttcttgt agcagaaatg tgaatgtttt cttgaagtac aggttacggt     4980

tttcatggta caagtgctta cctacgacga taagagaaca aggcttaaaa tatccctcaa     5040

aagaacaatt gtgagaattc catgttagcg gctgtcttta aacgactacc ctcaggcaga     5100

tctgggtttt tatatcttta tcttcattca gtgaagcaag ccaaaagccc acatttgtat     5160

gccttaggtc ttcttaaaat ggtatctgta aacatgtgtc caatataaaa actattttta     5220

ataaaaagtt acatgaaaca ga                                              5242


<210> 502
<211> 625
<212> DNA
<213> Homo sapiens

<400> 502
caacaatcca ttggctaacg aggtcgatga cgccagacgc aagacgccgg gcctacagcg       60

ggagcgtgag gaaagccgtg cgttgcgttc caaggcatct gtgagcccgc ggagtataca      120

ccatgagcaa agctcaccct cccgagttga aaaaatttat ggacaagaag ttatcattga      180

aattaaatgg tggcagacat gtccaaggaa tattgcgggg atttgatccc tttatgaacc      240

ttgtgataga tgaatgtgtg gagatggcga ctagtggaca acagaacaat attggaatgg      300

tggtaatacg aggaaatagt atcatcatgt tagaagcctt ggaacgagta taaataatgg      360

ctgttcagca gagaaaccca tgtcctctct ccatagggcc tgttttacta tgatgtaaaa      420

attaggtcat gtacattttc atattagact ttttgttaaa taaacttttg taatagtcaa      480

aaatgctttc tcagatgttc tgaatataga atatcagctc tcattccagt tttttctaac      540

atgaattttc ctggttgaca ttgatttcaa agggttttat gcattaaagt gaaagaatct      600

tattaaatgt gaaacatggc aagga                                            625


<210> 503
<211> 748
<212> DNA
<213> Homo sapiens

<400> 503
aagacgggga ttggccatcg cttccggaag ttgtgagctt tgtttcggag cgggagctct       60

tccgagacgc actgggggcc ggatgtagaa tcctgcttat ctgtgaaatg cagttaacac      120

atcagctgga cctatttccc gaatgcaggg taacccttct gttatttaaa gatgtaaaaa      180

atgcgggaga cttgagaaga aaggccatgg aaggcaccat cgatggatca ctgataaatc      240

ctacagtgat tgttgatcca tttcagatac ttgtggcagc aaacaaagca gttcacctct      300

acaaactggg aaaaatgaag acaagaactc tatctactga aattattttc aacctttccc      360

caaataacaa tatttcagag gctttgaaaa aatttggtat ctcagcaaat gacacttcaa      420

ttctaattgt ttacattgaa gagggagaaa aacaaataaa tcaagaatac ctaatatctc      480

aagtagaagg tcatcaggtt tctctgaaaa atcttcctga aataatgaat attacagaag      540

tcaaaaagat atataaactc tcttcacaag aagaaagtat tgggacatta ttggatgcta      600

tcatttgtag aatgtcaaca aaagatgttt tatgaaatgt cagaaatatt aacaaaaatt      660

ctcagcatta aagaaaacat tgattttcct ttcctgacta taaaactaat tgtgcattat      720

agaaaagttt aaatcacaga atggtatt                                         748


<210> 504
<211> 1860
<212> DNA
<213> Homo sapiens

<400> 504
ctgcagctca ctttctccct gtttgctggc cagcagggtt tgtggccgcc tctgctgtga       60

cgccacagcc tggtgaggag ggggctgcag ttcctcagga aactgccagt ggacaaagtc      120

ataaacaaga gttccagttc cctggaacct gagtcgggag gcctgcaact cactttctcc      180

ctgtttgctg gcccagacag gcctgtgcta gagggctgga tagtgtggta gtgtggtgga      240

tagagtgctg cctctatcca caacgcagcc atatgctgac tgaagataac tttgtgtctg      300

gaagagccct ctgatttctt acactaatgg ccttacacga catggaggat tttacatttg      360

atggaacaaa gcgcttaagt gtcaactacg tgaagggaat tcttcaaccg acagacacct      420

gtgacatctg ggataagatc tggaacttcc aagccaagcc tgatgacctg cttatttcta      480

cctatcctaa agcaggaaca acatggactc aggagatagt ggaattaata caaaatgaag      540

gtgatgtgga gaaaagtaaa cgggcaccga ctcatcaacg atttcctttc ctcgaaatga      600

aaatcccatc cttaggatct ggtttggaac aagctcatgc aatgccctca ccacggatcc      660

tgaaaacaca tcttcccttt cacttgctgc caccatcctt gctagagaaa aactgtaaga      720

taatctatgt agcaagaaat cccaaggaca acatggtgtc ctattaccat ttccaaagaa      780

tgaataaagc tcttcctgct ccaggaacat gggaagagta ttttgagact tttctggctg      840

ggaaagtgtg ctggggctcc tggcatgaac atgtgaaagg atggtgggaa gccaaagaca      900

aacaccgtat tctctatctc ttctatgagg acatgaagaa gaacccaaag catgaaattc      960

agaagctggc agaatttatt gggaagaaat tagatgacaa agttctagat aaaattgtcc     1020

attacacttc gtttgatgtc atgaaacaga atccaatggc aaactattca tcgattcctg     1080

ctgaaatcat ggaccactcc atttctccat tcatgagaaa aggggcagtg ggagactgga     1140

agaaacactt caccgtggct cagaatgaga gatttgatga agattacaag aagaaaatga     1200

ctgataccag actaactttc cacttccagt tctagtaagg aagaaaaact gaaaatgttt     1260

tagtttatta cccagtatat ttgggtaata atgaaagttt aattctcata acaaatgata     1320

tcagattcca gttatcagaa tagtttactg tgtttgctct tattcactct actaaaaaat     1380

tattttaaaa ggctggaggc aaggtggtga caggcagcag ggtggcgaca tggagagagg     1440

gaagctcaat aaatcactag gtacaatcct ggtatcattg ccaattatca tcatatttac     1500

attttctaca atcatgtgct tattaacata ttggaaatgc ttcagtcctc acatgataat     1560

acactaacat tttcagatta agttttggtt caagttaatt tttttttttt tttttttgag     1620

acggagtctc gctctgtcgc ccaggctgga gtgcagtggc acgatctcgg ctcactgcaa     1680

gctctgcttc ctgggttcac gctattcccc tgcctcagcc tcccgagtag ctgggactat     1740

gggcgcccac caccactccc ggctaatttt tttttttgta ttcttagtag agacgaggtt     1800

tcaccgtgtt agccaggatg ttctcgatct cctgacccca tgatccaccc gcttcggcct     1860


<210> 505
<211> 5279
<212> DNA
<213> Homo sapiens

<400> 505
gcgggcttgg ctggcctggg gctcggactt ggggccggag ccgcgggagc cggcggacgc       60

tggaccagga gccccgacgt gatcgcgtgg cgggtggtcg ggtctccggg tggccgggtg      120

tcggccccgg gatccggcgg ctcgctggcg ggagtcggcg gcctctgctg ggcctgggtc      180

ccggctcccg gcccggcccg ctcccactgc ggccgccatg tggtgcctgc actgcaactc      240

ggagaggacc cagtcccttc tggagctaga gcttgacagc ggcgtcgagg gcgaggcccc      300

cagcagtgag actggcacat ccctggacag cccctcagcc tacccccagg gccccttggt      360

gcccggttcc agcctgagcc cggatcacta cgagcacacg tcagtgggag cctatgggct      420

gtactcgggg ccgccggggc aacagcagcg cacgcggagg cccaagctgc agcactcgac      480

ctccatcctg cgcaagcagg ctgaggagga ggccatcaag cgctcacgct cactctccga      540

gagctatgag ctctcctcgg acctgcagga caagcaggtg gagatgctag aacgaaagta      600

tggggggcgc ctggtaaccc gccatgcggc ccgcaccatc cagacggcgt ttcgccagta      660

ccagatgaac aagaacttcg agcgcttgcg cagctccatg tcagagaacc gcatgtcacg      720

ccggattgtg ctgtccaaca tgaggatgca gttctccttt gaggggcctg agaaagtgca      780

cagctcctac ttcgagggga agcaggtctc agtgactaac gacggctccc agctgggagc      840

cctggtgtcc cctgagtgtg gtgacctcag cgagcccacc accctcaagt ctccggcccc      900

ctccagtgac tttgcggacg ccatcaccga gctggaggac gccttctcta ggcaagtgaa      960

atcactggcc gagtccatcg acgatgccct caactgccgc agcctgcaca ctgaggaggc     1020

accggccctg gatgcggcgc gggcccggga caccgaaccc cagacagccc tgcacggcat     1080

ggaccaccgc aaactggacg agatgacggc ctcgtacagt gatgtcaccc tgtacatcga     1140

tgaggaggag ctgtcgcccc ctctgcccct ctcgcaggca ggggaccggc cgtccagcac     1200

cgagtcggac ctgcggctac gggctggggg cgcagcccca gactactggg ccctggccca     1260

caaagaggac aaggctgaca cggacacgag ctgccggagc acgccgtcgc tggagcggca     1320

ggagcagcgg ctgcgggtgg agcatctgcc gctgctcacc atcgagccac ccagcgacag     1380

ctctgtggac cttagtgacc gctcggagcg ggggtcactc aagaggcaga gtgcttacga     1440

gcgcagcctt ggcgggcagc agggcagtcc caagcatggt ccccacagcg gcgcccccaa     1500

gagcctcccc cgggaggagc ctgagttgcg gccccggccc cccaggcccc tggacagcca     1560

cttggccatc aatggctcag ccaaccggca gagcaagtct gagtcggact actcagacgg     1620

tgacaatgac agcatcaaca gcacgtccaa ctccaacgat accatcaact gcagctccga     1680

gtcatcgtcc cgtgacagcc tgcgggagca gacgctcagc aagcagacct accacaagga     1740

ggcccgcaac agctgggact cgcctgcctt tagcaacgat gtcatccgca agaggcacta     1800

ccgcatcggc ctgaacctct tcaacaagaa gcctgagaag ggagtccagt acctcatcga     1860

gcgtggcttt gtgcccgaca cgcccgtcgg ggtggcccac ttcctgctgc agcgcaaggg     1920

cctcagccgg cagatgatcg gcgagttcct gggcaaccgg cagaagcagt tcaaccgtga     1980

cgtgctcgac tgcgtcgtgg acgagatgga cttctctacc atggagctgg atgaggccct     2040

caggaaattc caggcgcaca tccgtgtcca aggggaggct cagaaagtgg agcggctcat     2100

agaggcgttc agccagcgct actgcatctg caaccctggg gtggtgcggc aattccggaa     2160

cccagacacc attttcatcc tggccttcgc catcatcctg ctgaacaccg acatgtacag     2220

ccccaatgtc aagcccgagc ggaaaatgaa gctagaggac ttcatcaaga acctccgagg     2280

tgtggacgat ggtgaggaca ttccccgtga gatgctgatg gggatctatg aacggatccg     2340

taagcgagag ctaaagacca atgaggacca tgtgtcccag gtgcagaagg tggagaagct     2400

cattgtgggg aaaaagccga tcggatccct gcatcccggg ctcggctgtg tgctctctct     2460

gccccaccgt cggttggtct gctactgccg gctctttgag gttccagacc caaacaagcc     2520

ccagaaactc ggactacacc agcgagaaat cttcctgttc aacgacctcc tggtggtcac     2580

caagatcttc cagaagaaga agaactcggt gacgtacagc ttccgacagt ccttctcctt     2640

gtacggcatg caggtcctgc tcttcgagaa ccagtactac cccaatggca tccggctcac     2700

ctcgtctgtc cccggagcag atatcaaagt gttaataaac ttcaacgccc ccaaccctca     2760

agaccggaag aaattcaccg atgacctgcg ggagtccatt gcggaagtcc aagagatgga     2820

gaagcacagg atagagtcgg agctcgagaa gcagaaaggc gtcgtgcggc ccagcatgtc     2880

ccagtgctct agcctcaaaa aggagtcggg caacggaaca ctgagccggg cctgcctgga     2940

cgacagctat gccagcggtg agggcctcaa gcgcagcgcc ctcagcagct ccctgcggga     3000

cctctcggaa gccgggaagc gagggcgtcg cagcagtgcg ggatcgctag agagcaatgt     3060

ggaatttcag cctttcgagc cactgcagcc gtcagtgctg tgctcctaag ccatgggacc     3120

cgaggactgc cccccggcgc ctgcccaggc ggaggccctt tcagaaaggg cgaagctcac     3180

gcctgactct gcgggccgcg gggccgcgtt cccagtggac agcgtggtga gccgtggccg     3240

gacggcagga ggagagggga gccccctctg gctgtgtgtc accttggctg gctggctggc     3300

cagggttttg ccgatttccc tcctcacatc cctcccaccc tcggtcatat cattgagatc     3360

accgtaccag caaatctgca aaccaagcac tttgttaatc tccagagaga gcaaatacag     3420

caatctagag tttagccttt ttaaaaatgt gactttaacc cgcccacctg tgtcctccca     3480

ttggcgtggc atttctttgg tgtctgctca gaaagaaaca gcatgggacc gtgtgattgg     3540

gtccaggctg ggctgtcagg gaagcgccct ggtgtctccg actcatcaat tctcgggtct     3600

tttttaaaag ccaggctccc caaagcactc tgtctcgcaa ttttgaggag gctgttccga     3660

cctggaagcg ttaaactgct gcatgtcatc tggcgtcagc tgtgaggctg cgctctgcgt     3720

gttgtgcgtt tgcaaaatgt attggcgtga ctgtaaacac atcgttgaag taaagcgatt     3780

acatattgag tatgtcagct tttctcaccc tcttctgtgc tgggaggaga gtctaactgt     3840

aacctttagg ttgttccaga aaagattcag gccgtttggc acagaattgc tctttctgaa     3900

gggtagcagt aatgaatagg aacagacaga aaaccccagg aggggctttc aggaaactct     3960

ccctctccat cgccatcctg caagctccac agcctcgggc tgccagcctg tggcactgtc     4020

ctcggtgtgt cctggagctg tgctgggcag cagggcctcg cgtaaggaac tgctggaacc     4080

cactgagccc ttcccggggt ttcccgccgc actcagtgtg ttccttcagg ctagtgaggt     4140

ttcattctgt tttatttgca agcttatcaa aagtttgtgg aagatacatt gttgggttcc     4200

agaggctgga gtcatgctgc ccacatcttg tttgggaaag caaaagctcc cagtgagctg     4260

gtgtccccgt gtgtctttca tgggactgtc ccctttagag atcccacctg tcagagccac     4320

agcttcgggg tcctgtcatc acatcccctg ggaggggagg caggaggagg ccgagggccc     4380

caggatgtct gcctggtccc ttctcactgt gaggacgccc ttggcacacc tttctcaagt     4440

cacacaaatt actgcagtta catacagaat tgctgacagg agcaggagac gctgagggaa     4500

acagctggca atgtgacaaa agtcttttct gggacaacaa tcaaatcatg tatttgtatt     4560

tttttaagtt taccaatgaa ttgtacaaca atgtaaaaat aaagttcatc ctaatatgct     4620

gtgcacatct tgcttaaaaa tgtcttcagc acccagtgca gtgatctttc cctcacacac     4680

tgcatgcagc aggagcctct tgtttttctt aatgagctga aaagacagca gatgttcaca     4740

gctgatgctg ggtgttgact cagcgccacg ggaagctctg tgcccgcagg taagcacgca     4800

cagtcttaca gttctccttg taaaatatca tcacccttcc tgcctgagaa acgagtacat     4860

ttgtatttta tgtaacaaca atagtcaagg cagcattgca acactgagca gggtgaggtg     4920

ggggtgctga gcacaggaca agagggagga ggcctgccct ccattcagat gcatctgcat     4980

cgcccttctg tgtgcagtca catcgagact gcacacagca tgcatctcct cttggaaaat     5040

atcttttgcc tccgagttgt tttaagcaat tagaatcagg tcctgaatcc ccagactgtt     5100

cagagacttc aagggacacc tccctcacaa gaagcctggc acccccactg tgtacctttg     5160

agaggaaagg agtgcgtttg ttttcatctg cattctgttt gtcagtggca acagactcta     5220

tcaatgtaaa accatggttg tgatcatgtg gggaaatcaa ataaatcctt tgaaactct      5279


<210> 506
<211> 3883
<212> DNA
<213> Homo sapiens

<400> 506
aggcgttaac ccagggaagg cagtggcaag atggcgtccc tggatcgggt gaaggtactg       60

gtgttgggag actcaggtgt tgggaaatct tcgttagtcc atctcctatg ccaaaatcaa      120

gtgctgggaa atccatcatg gactgtgggc tgctcagtgg atgtcagagt tcatgattac      180

aaagaaggaa ccccagaaga gaagacctac tacatagaat tatgggatgt tggaggctct      240

gtgggcagtg ccagcagcgt gaaaagcaca agagcagtat tctacaactc cgtaaatggt      300

attattttcg tacacgactt aacaaataag aagtcctccc aaaacttgcg tcgttggtca      360

ttggaagctc tcaacaggga tttggtgcca actggagtct tggtgacaaa tggggattat      420

gatcaagaac agtttgctga taaccaaata ccactgttgg taatagggac taaactggac      480

cagattcatg aaacaaagcg ccatgaagtt ttaactagga ctgctttcct ggctgaggat      540

ttcaatccag aagaaattaa tttggactgc acaaatccac ggtacttagc tgcaggttct      600

tccaatgctg tcaagctcag taggtttttt gataaggtca tagagaagag atacttttta      660

agagaaggta atcagattcc aggctttcct gatcggaaaa gatttggggc aggaacatta      720

aagagccttc attatgactg aattacactc atcctttgga agagtgagca agcagtggca      780

gtttttcaca gctcatcttg ctgtgttcaa ttattaccat cacagccttt taacaaaatc      840

atcttaaaat gctacccttc agccttaccc tttaatggaa aaatgaaagg aagtgacaat      900

acgggaggtc caaactttgt ccctgttctc tgtgttcctt acctttctgt ccctgtgtat      960

agattatgta aaagccttgt gtaaatatga gatgttgtca aaatgatgca gtaaatgagc     1020

aatgacagtg tactgcagag aaaatttact cttgcctaga actggagggt ttttatgggt     1080

ctgtaatttt cccacactca ttgctgaaag cttaattaag tacttcaaaa acgtatctcc     1140

attgttttac cttcttgagg ggaacggtct tgttaaccag ccctgagttg tctaccccaa     1200

acaatctctg tcattttcaa agatgcaaaa tggtgttatt taattgtctc caccattgtc     1260

acacacagga atgcctaata atagcaaccc ttgtctccct cttctctcct ttgcaaatgg     1320

ctcagtgact ggaagaggcg gactaatagc cagagttaaa tataaataca aattaataat     1380

acatagagaa cagcaatacc agaaaaaaag aattctggta aaatgatgtg aaaaattgac     1440

agctccctca ctcttaaggt tgctgctata tacagtctag gttttctgtt tggaaatagg     1500

tagggtaaaa tctaagacct gcacaagggc agtgagagac atttacagcc tcctctctat     1560

ttgttttttt aaggaaaagt caactcctga aatgtccctt agctataatc agaaaactaa     1620

gaatattatt ctgtgtcaac aatgtattta tggagagaag taaaaataag ttccacagca     1680

acacatttac atgaattatg aactaggatt cttggatttc ataatcactc caaagctttt     1740

tggggatggt gtgtgtgtgt gtgtgtgtcc gtaattgttc atcattactt tttttaacct     1800

atctttttgc ttgcttaatc ttctctgccc cagttcttcc tgagtatatg aatttgattt     1860

ctaaaaacaa tttattcaac actctatcac ccgtattctc tctctggctc tgctgcaggt     1920

ctctgcactc ctgattttgc tccatacttt taaataacaa taataaatat acagttttca     1980

tttctcattt aaaaaatagg tggaaaacac caaattcact ttctgttcca ttttaattag     2040

gtttcagaag tatcttggaa atcaaggtat gctgcaagag gatattaaaa taagaatgtt     2100

agagagtcct tttagaaagg cagtcttggg aatttggaaa aggattttta aagcagcttt     2160

catcagctag actgttctcc agcctttctt tacttcctct ttgaaaggac atagccctgg     2220

tttctttttg acacaaagga aagctatgca aatcatgatc tgtatgtaga attggtcaca     2280

agtatgttgt tgcataggct gtacagttgg gaagtagaaa ccaaatgcta cccagagacc     2340

taacccaatt aagctctttg tatttctcct tcaagaaata aatcttcctt ccttctttct     2400

tcctctttct tttaatttta aaaaaattca tcctgatttt tttattttct atcttattta     2460

aaaaataaaa ataggccagg cgcggtggct cacaccttta atcccaacac tttgggaggc     2520

gggtcgatca cttgatatca ggagtttgag accagcctgg ccaacatagg gaaaccctgt     2580

ctctactaaa aatacaaaaa ttagccaggc ctggtggcac gcgcctgtaa tcccagctac     2640

ttgggaggct gaggcaggag aatcacttga acctgggagg tggaggttgc agtgagtcaa     2700

gatcgtgtca ctgcactcca gcctaggtga cagagtgaga ctccaactaa aagaaaataa     2760

ataaataaat atataaatat ataaataaat aataaaagta aactattgct gatgactcca     2820

gggtcaatct ggaaaaatta acagtattcc tcaactccat tactttctgc agccaagctt     2880

gattccttga attatagttt tctaagaaaa aatagttttt aataatctaa ggtaaatttg     2940

ttgcaattat tagcagcagc ataataaggc tttttgcgca aatgaatgtt attagctaga     3000

gttattcaaa aaagaatgaa gcacaatttt tgctaggact tcttgagaac tattcataaa     3060

aatgctttta gataataaac aagtataaat gtcaaaatat ttttttaaaa gtataattgg     3120

ccaggtgctg gctcacgcct ataatcccag cactctagga gactgaggca ggaggatcac     3180

ttgagctcgg gagtttgagg ctgcagtgat tcatgattgc accactgcct tccagcagcc     3240

tgatgacaga gtgggactcc atctctttac atatgtatat cttactctct tgatgggaca     3300

agttggtaga aataaagatt ttttttttct gttgtgattt cggtgtctga ccaattttct     3360

gactcattgt gaaggtgacc agatatgaag gcatatatat gactactcct ctgtccctta     3420

ggtgtataag acttagctgg aatccaacta aagatttggg ctggtctctc catcttaacg     3480

ttgatgggat tcaggacaca taaccccaaa atattgcacc ctgttatttg agaaaactgc     3540

agaagcaagg tttctcatac cttcccctta ccccttctcc cctgaagcag gccataaacc     3600

ctaagtgact gttccctgaa gtagatcata aaaccttcat tccataggta ccctttatcc     3660

tcacagatac agagacacca agaagaatct ggacaaatag gacttgctaa gttctccaca     3720

gtttattacc attagattat gtccttttgt cctctgatta tacttctgca taagactgta     3780

cataaaaata cacaagtttt cctatttctt ttttgtcttc atttctgaag attcctgtca     3840

tgtaaaactt acagtaaata aatgtgtgtg cttttctcaa taa                       3883


<210> 507
<211> 6955
<212> DNA
<213> Homo sapiens

<400> 507
gagcagttcg actttccgcc caaactgggg gatgctagac cgcgggcacc tctgaatctt       60

atgccttcag tgatataatc ctccgtgtcc ttcgagtccc tcctgctgca gacaggtccc      120

ctatacttcg gtacacacga gcctttcgcg cccaccgcaa cgcagcctcg ggaggcagga      180

cagacccctg cgagtgtaga ttgcagctgc atcccagctc ccccctccct ggcacgctcc      240

tccacctaca gctgcgctga gctgccgcat ctgaacgcaa agcaaacgct gcagtgacgg      300

ttcctgcgtc accttaactc caaagtaaat gctaacgttt cccgtgtctg taccttctct      360

caatcggcac tctcaaaaca tctggcacgg tgttcactac cctaataaga cctcagcttc      420

cctcgggagg ggagggagca ctggcagttg ctgggtaatt tgaagacgac ggtggagggt      480

ttggtatcaa ccaacagccc caacgtctgg tctaagtatg gtggcttgga gcggctttgc      540

agggacatgc agagcatcct ctatcacggg cttatccgtg accaggcgtg ccgccgccag      600

acggattact ggcagttcgt gaaagacatc cggtggctca gtccccactc agcccttcac      660

gtggagaagt tcatcagcgt gcacgagaac gaccagagca gtgctgatgg tgccagtgaa      720

cgtgctgttg ccgagctgtg gctgcagcac agcctgcagt accactgcct ctcagcccag      780

ctccggcccc tgctcgggga tagacagtat atcagaaaat tctacacaga tgctgccttc      840

ctgctaagtg acgctcatgt cacggccatg ctgcagtgcc tggaagcagt ggaacagaac      900

aacccccgcc tcctggctca gatcgatgcg tccatgtttg ccagaaagca cgagagcccg      960

ctcctggtga caaagagcca gagcctgaca gccctgccca gttccacata cacccctcca     1020

aacagctatg ctcagcattc ctactttggg tccttctcta gcctccacca atccgtgccc     1080

aacaatggct cagagagaag atctacttcc tttccactct ctggccctcc ccggaaacct     1140

caagaaagca gagggcacgt ctcaccagca gaggatcaaa ccatccaagc ccccccagtt     1200

tcagtctctg cactagccag ggattcccct ttgaccccaa atgaaatgag ctccagtact     1260

ctgaccagcc ccatagaggc atcctgggtc agcagccaga atgattcccc aggtgatgcc     1320

agtgaggggc ctgagtacct ggccattggc aacttggacc cccgaggccg gactgccagc     1380

tgtcagagtc acagcagcaa tgccgagagc agcagttcca atttgttctc ctccagcagc     1440

tcccagaagc cagattctgc tgcctcttcc ttaggggacc aggaaggagg tggggagagc     1500

cagctgtcca gtgtcctccg caggtccagc ttctcagagg ggcagacact cactgtcacc     1560

agtggggcaa agaaaagcca cattcgctcc cattcggata ccagcattgc ctccagggga     1620

gctccaggag gccccaggaa tatcaccatt atagttgaag atcccattgc agaatcctgc     1680

aatgataagg cgaagttgag aggccctttg ccctactctg gtcaaagcag tgaagtcagc     1740

acacccagct ctctgtacat ggaatatgaa ggtggtcggt acctgtgctc aggggaaggc     1800

atgttccgaa gaccatcaga aggacagtcc ctcatcagct acctctctga gcaagacttc     1860

ggcagctgtg ccgacctgga aaaggagaat gcccacttca gcatctcaga gtccttaatt     1920

gctgccatcg agctaatgaa gtgcaacatg atgagccagt gcctagagga ggaggaagtg     1980

gaagaggaag acagtgatag agagatccag gagctgaagc agaagatccg ccttcggcgc     2040

cagcaaatcc gcaccaagaa cctgctcccc atgtaccagg aggctgagca cggaagcttt     2100

cgggtcacct ccagcagctc ccagttcagc tcacgtgatt cggcacagct ctctgactct     2160

ggctctgctg atgaggttga tgaatttgaa atccaagatg ctgacatcag aaggaacaca     2220

gcctcaagca gcaaatcctt cgtttcctcc cagtccttct cccactgctt cctgcactcc     2280

acgtctgctg aggcggtggc catggggctc ctgaagcagt ttgaggggat gcagcttcca     2340

gccgcctcgg agctggagtg gcttgtcccg gagcatgatg cccctcagaa gctcctgccc     2400

attcctgact cactgcccat ctcaccggat gacgggcagc acgctgacat ctacaagctg     2460

cggattcgtg ttcgtggcaa cttggagtgg gccccgcccc ggcctcagat aatttttaat     2520

gttcatccag ccccaacgag gaaaattgcc gtggccaagc agaattaccg ctgtgcagga     2580

tgtggcatcc ggactgaccc tgattacatc aagcgactgc ggtactgtga gtacctgggc     2640

aagtacttct gccagtgctg ccacgagaat gcccagatgg ccatccccag ccgggttctg     2700

cgcaagtggg acttcagcaa gtactacgtc agcaacttct ccaaggacct gctcattaag     2760

atctggaatg atcctctctt caacgtgcag gacataaaca gtgccctcta taggaaggtc     2820

aagctgctca atcaagtccg gctgctgcgg gtccagctgt gtcacatgaa gaacatgttc     2880

aagacttgcc gactggccaa ggagcttctg gattcctttg acacagtccc aggccacctg     2940

acagaggacc tccacctgta ctcactgaat gacctgactg cgaccaggaa gggggagctg     3000

gggccccggc ttgctgagct caccagggca ggggctaccc atgtggagag atgcatgctc     3060

tgccaagcca aaggcttcat ctgtgagttc tgtcagaatg aggatgacat catctttccc     3120

tttgagctcc ataagtgccg gacctgtgaa gagtgtaaag cgtgttacca taaagcctgc     3180

ttcaagtctg gaagctgtcc gcgctgcgag cggctgcagg cccggcggga ggcactggcc     3240

aggcagagcc tggagtctta cctgtcagac tacgaggagg agcccgcgga agcgctggcc     3300

ctggaagccg ccgtcctgga ggccacctga agaaagcacg tgcagccctc cctccgggcc     3360

gggtcacacc tgttgcagaa ctgagccact ctttgaagga ctcgccccac ctggggcttc     3420

tttttttttt ttttttttta attatcatca tctttttttt tttttttact gacttgtctg     3480

acgtctgtgt gcagtcagcc gtcggcaggt tgatgggtcc agagtctgtg gtgacagata     3540

atttgtaaac accaggtgtt tccatcagaa ctgacatgcg ggtccttcag tgaagcttct     3600

agtgcctctg tcagtggaag agacagcaag accaagttct tccagcgtct gtggccttct     3660

cctctaggtt tcacctgcat gtcaggtatc atttccaatt ttcctttgtt tcagttctgg     3720

agcttctgag ccaggccttt ctcaaccacc tctcctgctg ctgaaacggg gatggcgttt     3780

tccctctccc tgtcctggac tggggtcaga ctgtgccccg aggagaagca gcagagaata     3840

ggactacgtc atgggcattt cgtccactta tttgggtatt ttgggggcca cagaacaatc     3900

ctgactatcc tagactcctc agagacctca gaggcagctg tgaatgtccc tatgttgccg     3960

ggagttcctg tttgaaatat ttgaagcata gaggatgcca caagctgact ttcttcatct     4020

accttggtga tcttgaagca aagaacagaa ctgatgctca ggccaggctc acctgtagcc     4080

ttacgccgca agcatacgtg aggcgccagc tctgtcgctg aaggagcgct tactcagagg     4140

agcggtcggc cccctcttgg tgttaaggtc tcttagttaa cctggctttt tggtgcaggt     4200

gtgatctttg aagctcaggc aggtccctga tgccatccta aggtgaggac aggaacctca     4260

cccaccatct tcttagcgtg tccctgatga ctctgtcctc tgttagatgg tcgttgtgct     4320

tctgagtaaa agtacaaccc gactccgttc tctccccttc ctgcagcaga gctgggtcct     4380

tccctggtgg ccgagtctct cttgccttag cttctttggt caaagttgga gaaaagcttc     4440

ctgctattag tgctgttaca gaacttgacg gtttgtggat gtgagtgtga atgtccctgt     4500

gttcttggga taacaagagc ctttatgcca attatgcact taactctgtg tagcctggta     4560

atgtttatct gttcatttga taatgctgat tttagtgtgc tgcccccctc cccccgttaa     4620

tgtgtgttga tggtgaagtc cttttgataa tgctgatttt ggtgtgctgc ctcccccttc     4680

ccccccgtta atgtgtgtgt tgacagtgaa gtccttgggt ggggccatgt gtgtgtttgt     4740

gatgttcctt aagttgatgc agcttctaac ctctgtgaaa acactggtca gagtggcttc     4800

tccaagagct ggcagctctg tgaactaaag cctgcatcat ttttgttctg ggattgaatt     4860

ctgcccatgg gcatgtcttc tcatagttgc ttgctggtag gaaagaaatg ggcgtgggtg     4920

ctgccctgga agctgagcgg aaagttgcct gtggttggtg gaagctgatg agagcttgag     4980

ctggcggtaa gaaggagtct cccagggaag tgggagaggc attaaggtga tggccagggc     5040

tgaggctcca ccagcgtgag agggaacatg tgggaactgg cccctgccct tgattcctct     5100

gcctcaaagt tgggatctga aagccatgta gggctagaag accctgaggc tgttctccct     5160

tctgttcata gtgagactca aaaagccaag tcccagaagt tctgaagggc tgtgactaga     5220

agtgcccagg tccttcaggg agctttaaga atgaccccac agaactcaag tttaactagg     5280

ggttaggtcc cagattcaga cccaggagtt tataaaaatg agctctactt ccagttttgg     5340

tttaaattac acatccaggc caggcacagt ggctcacacc tgtaatccca gcactttggg     5400

aggccagtgc gggcggatca tgaggtcagg agtttgagac cagcctggcc aatgtggtga     5460

aaccctgtct cttccaaaaa tacaaaaatt agctgggcgt ggtggcacac gcctgtaatc     5520

ccagctactt gggaggctga ggcaggagaa tcgcttgaac ctgggaggca gaggttgcag     5580

tgagccgaga ttgcgccacc gcactccagc ctgggtgaca gagtgagact ccgtctcaaa     5640

aaacaaaaag gtgacacatc cagctctttc tccaggtcac tgcgctggag gacagatgtg     5700

ccgtcttgtc ctgcctgttt cacatcagca taggatcaaa ggatgacaat gctgacagct     5760

tctgaagccg aactcaacag tctcataggc tcctcacttg tcacttattt ttccctagct     5820

ccctcaaccg caccccatcc ctttagatcg tgcgtctgtt ttagtgactc tgacacgatg     5880

ccgtcctcac cttccaaata cccagttatt tattcaagag gggggaagtg ggtagaggat     5940

gggatgtttt ggaagcactt tgcaagttac cactatctga aaatcccctg ctgttgcggg     6000

gagaagcttt gaatgcactg aagagaattc cttctaaatg aaggcaggtg atagtgttct     6060

ttctgtaagt aaagggaaag aaaaaaaaca tagtttgctt accaggtgga gacaagattc     6120

aagacatagc agaagagtgg aagacaaata ttttccactt aaatgaggct gtttttgacg     6180

ttctctgcca aggatttaga gctttcgttg aactaacata aaaggagtgc gagtcttagt     6240

agagatgttc cgtgtgtgcc gcccgtgctc tgaactgcgt ttccacctgc tgtggtgctt     6300

gtgcagcctg gcagttcatt gtcatcttta ataaactaag gaaataaaat tctgtctttc     6360

gtcagcctgc cttgactgtc aagaaatggc atgtgtccac tgtaaagcag gtatatctga     6420

acattgagaa ggtttctgtg ttataatgta aagcaaactg gaccacacac atcaaggaaa     6480

gtgaggtgga gtggctgtgt ctctaacttg ccatgagacc tcgagcgaac cacttcactt     6540

ctctgggttt ctggtgcatg gtgtaactgt cacttaaaat gaggtgtctt cctctccgca     6600

acatctgact tgccttagat gcttcagttc ccacttctgt gagcagctag catctttctc     6660

ttctgctcct ggcccactgg agctccagct ctacgctgca actctctcaa catttcccct     6720

taaatgtccc cttgtcatct ccaaccagtg tgtctaaaac cagcataaat tccgtatttc     6780

caaaaaccta accattagtc acccaggttt gaaaattaat tgtcttcaac ttcctctgta     6840

agtggcacac tgagctcatc acgcatcgtc tcattcctac tccctgtcat caagttctgt     6900

ggatgttttc ctctaaaata aatctctcat tacttttctg ccactagcac acaaa          6955


<210> 508
<211> 636
<212> DNA
<213> Homo sapiens

<400> 508
ggaaggaagc cggggagaca ggtggggtac tcgggaagct ggagcgggcc ggcggtgcag       60

tcacggggga gcgaggcctg ctgggcttgg caacgaggga ctcggcctcg gaggcgaccc      120

agaccacaca gacactgggt caaggagtaa gcagaggata aacaactgga aggagagcaa      180

gcacaaagtc atcatggctt cagcgtctgc tcgtggaaac caagataaag atgcccattt      240

tccaccacca agcaagcaga gcctgttgtt ttgtccaaaa tcaaaactgc acatccacag      300

agcagagatc tcaaagatta tgcgagaatg tcaggaagaa agtttctgga agagagctct      360

gcctttttct cttgtaagca tgcttgtcac ccagggacta gtctaccaag gttatttggc      420

agctaattct agatttggat cattgcccaa agttgcacgc actgcctcct tacctgtgag      480

gaatgcaaaa taaagcatgg attaagtgag aagggagact ctcagccttc agcttcctaa      540

attctgtgtc tgtgactttc gaagtttttt aaacctctga atttgtacac atttaaaatt      600

tcaagtgtac tttaaaataa aatacttcta atggaa                                636


<210> 509
<211> 2025
<212> DNA
<213> Homo sapiens

<400> 509
aagggccgcc ccttttcctg cccacgtggt ctcgggctcc tgccccgtcc tgctcacgag       60

ttcagggctc ctgggcggcc gccttttcca gttccaggtg tgcagaagtg tcctctcccc      120

acgcgcggcg ggctgcactt ggtcgctggc tccgagatcg cgcggggccg ccggaagccc      180

aagacggtac cgggggccgc agccgcagcc ggcgccgccc tccgccctcc ccaacagcag      240

gccgagtccc gtagcatccg gtagggaaat ggtcgtgctt tcggtccccg ccgaagtcac      300

cgtgatcctg ttagatatcg aaggtaccac aaccccgatt gctttcgtga aggacatttt      360

atttccttac atcgaagaaa atgttaaaga gtatctgcag acacattggg aagaagagga      420

gtgccagcag gatgtcagtc ttttgaggaa acaggctgaa gaggacgccc acctggatgg      480

ggctgttcct atccctgcag catctgggaa tggagtggat gatctgcaac agatgatcca      540

ggccgtggta gataatgtgt gctggcagat gtccctggat cgaaagacca ctgcactcaa      600

acagctgcag ggccacatgt ggagggcggc attcacagct gggcgcatga aagcagagtt      660

ctttgcagat gtagttccag cagtcaggaa gtggagagag gccggaatga aggtgtacat      720

ctattcctca gggagtgtgg aggcacagaa actgttattc gggcattcta cggagggaga      780

tattcttgag cttgttgatg gtcactttga taccaagatt ggacacaaag tagagagtga      840

aagttaccga aagattgcag acagcattgg gtgctcaacc aacaacattt tgtttctgac      900

agatgttact cgagaggcca gtgctgctga ggaagcagat gtgcacgtag ctgtggtggt      960

gagaccaggc aacgcaggat taacagatga tgagaagact tactacagcc tcatcacatc     1020

cttcagtgaa ctatacctgc cttcctcaac ctagagaagg gttgttaagg cagaccgccc     1080

tgttccccag agttgtccct gtagtgtcta ggtttattct aatggtaaaa gtaacttact     1140

taaaaaacat atgtacacat atgtatgcaa gtatgtatat atgtgtatgc tcagattaac     1200

ttccataggt acataagtga aagaagtctc agttcagtga acacaaaact tatttaaaga     1260

tgctttatat gtagaaattg tttcaaatca tactctaacc cttagtgagg gcaaagtgta     1320

gttggtagaa gaaattgcta aatacctatc taatgtgcta tgtttatcaa atcgtgtact     1380

aaaatggaaa gctagttttg agaaattatt cagaagcctt gttattttaa aaatgaaata     1440

tttcaaagac tgaatatttt caaagaaaat gaataattca ttgcccttgt gatttagaag     1500

attataacag ctgtatttca tatttgcctc cttatatata tcaaagacca aggtatttcc     1560

ttctgcttca aaagaacaaa attgggaaag aaaactcact tgagtcttga tcaaacaagt     1620

gtcttttact taagaagaaa cttggtaatc attgtggcac ccacagcaag cagttgcctt     1680

accagtgaaa aaggtgcact gaggtaacat ctaaaacaga gatgtggttc ttaatgttta     1740

acagaacagt tctaatcctg ccacgtgtta tcattataga ttttatagtt gcctttctaa     1800

ctacttagca cagtttgaga atacgttaat tgctatttac tatttaaaaa gttttactga     1860

aatcagtcca taacattaag atgagcccta atatgtaaga ttttcctctg gaatggatgt     1920

gagaaatgta aattttataa cagcagtatt tatcctggtt taattctaat acgatgtcat     1980

gttaatttca tgttgtgatt aataaaagca ttttttcttc actca                     2025


<210> 510
<211> 1517
<212> DNA
<213> Homo sapiens

<400> 510
agagatacca ctgagtccag aagcaagacc tgtgagagtg cacagtgcca cttcgcccca       60

tggctgaaga tggtttgccc aaaatttatt ctcatcctcc aacagaaagc agtaaaacac      120

caactgcagc aaccattttc tttggggctg acaatgctat tcccaaatca gaaacaacta      180

ttacttcaga aggagaccac gtcacttcag taaatgaata tatgctagaa agcgattttt      240

caacaactac agacaacaaa ctgacagcta aaaaggaaaa actcaaatca gaagatgata      300

tggggaccga ctttattaag tcaacaactc acctacagaa agaaattacc tctctgactg      360

gcactacaaa ctccataaca agagactcta ttaccgaaca tttcatgcca gtgaaaattg      420

ggaatatttc atcaccagtt actactgttt ctttaataga tttttccact gacatagcaa      480

aagaagatat cctcttagct accattgaca caggagatgc agagatctca ataacctctg      540

aagtctctgg cacactaaag gacagcagtg ctggtgttgc tgacgctcct gcctttccac      600

gtaaaaagga tgaagctgat atgagcaatt ataattcctc catcaaatcc aatgtccctg      660

ctgatgaggc tgtccaggtc actgattcca ctattcctga ggctgaaatc cctcctgctc      720

ctgaagaaag cttcactact attccagaca taactgccct tgaagaagag aaaataaccg      780

aaattgacct aagtgtttta gaagatgaca ccagtgctgt ggctacatta actgactctg      840

atgagaagtt tatcactgtg tttgaactca ctacctctgc tgaaaaagac aaagataaac      900

gggaagatac tctgctaact gatgaagaaa ctaccgaggg agccagtatt tggatggaga      960

gagatactgc aaatgaagca gagacccatt ctgttttgct tactgctgtt gaatccagat     1020

atgacttcgt tgtccctgca tcaatagcta caaacctagt ggaagaatca tctacagaag     1080

aagatttgtc tgaaactgat aatacagaga ctgtacctaa gatcactgag ccattttctg     1140

gaactacctc tgtattagat accccagact ataaggaaga cacctccaca actgaaacgg     1200

atatctttga actactgaaa gaagaacccg atgagttcat gatttaaaag caacaaaagg     1260

gataccatgt agaattgtgc aatagtctag ccagctagcc ttaacatcta agaaattttt     1320

ccaacaagca aaaaccttta gaaatgaaag aatgtgggca tttaaggtct taaacactga     1380

atatcacact cttcttatga ctcttgttag cgattcaagg acataaatct tcattctttt     1440

ctggcacaga ctacttaaat gggtctgttt tcactttgct catttttctt caataaatct     1500

ttttggcaag caactga                                                    1517


<210> 511
<211> 1104
<212> DNA
<213> Homo sapiens

<400> 511
agcacttgaa gttcaggcag cgagagttga catggggcca gggctgcgcc cctggggcgg       60

gttgaagaca gggtgagtct cttgatattc aggaaatcat cgcgcaccca gtcaccagcg      120

ttcgggagcc tgtcgcagcg ggaccgacgg aatccggagc aggcgacagg gcgcagaagc      180

gggatgtact tctgttgggg cgccgactcc agggagctgc agcgccggag gacggcgggc      240

agccccgggg ctgagctact gcaggcggcc agcggggagc gccactctct gctgctgctg      300

accaaccaca gggtcctctc gtgcggagac aacagcaggg gtcagctggg ccgcaggggc      360

gcgcagcgcg gggagctgcc agaaccaatt caggcattgg aaaccctaat tgttgatctc      420

gtgagctgcg ggaaggagca ctccctggct gtgtgccaca aaggaagggt cttcgcatgg      480

ggagctggtt ctgaagggca gctggggatt ggagaattca aggaaataag tttcacacct      540

aagaaaataa tgactctgaa tgatataaaa ataatacaag tttcctgtgg acactaccac      600

tccctggcat tatcaaaaga tagccaagtg ttttcgtggg gaaagaacag ccatgggcag      660

ctgggcttgg ggaaggagtt cccctcccaa gccagcccgc agagggtgag gtccctggag      720

gggatcccac tggctcaggt ggctgccgga ggggctcaca gctttgccct gtctctctgt      780

gggacttcgt ttggctgggg aagtaacagt gccgggcagc tggccctcag tgggcgtaat      840

gtcccagtgc aaagcaacaa gcctctctca gtcggtgcac tgaagaatct aggtgtggtt      900

tatatcagct gtggtgatgc acacactgcg gtgcttaccc aggacgggaa agtgttcaca      960

tttggagaca atcgctctgg acagctggga tacagcccca ctcctgagaa gagaggtcca     1020

caacttgtgg aaagaattga tggcctagtt tcgcagatag attgtggaag aaactctaag     1080

catggattta tgactttctt ttag                                            1104


<210> 512
<211> 2902
<212> DNA
<213> Homo sapiens

<400> 512
agggtgctcg gctcgcgggg actggcctcc ttcggcagct ggaggcggtc actcacgctg       60

ggctaggagc tgaggcgaga agggccatgc ggacggcgag ggagtccaga gccttgagcc      120

cggtgctcct ccctcgcgca gcggtggctc tgcggccgct ggagtaaaca ctgcctttgt      180

tccctagcgc ctcgtctttc gtcgccccgt gccctcacgc cgccgggctc tggccggccc      240

gccctcggtc cttgaacccc atttcggctc gtgccgtgcg gatgcagctg ccgggcctgg      300

gtttgggcat tgagcgggag gaggaggagg agcggcggcg cctgggcggc atgcgatggg      360

gaactgctgc tggacgcagt gcttcggact gcttcgcaag gaagcggggc ggctgcagcg      420

agtaggcggc ggcggaggat ccaagtattt tagaacatgc tcaagaggtg agcacttaac      480

aatagagttt gagaatctag tagaaagtga tgaaggggag agcccaggaa gcagtcatag      540

gcctcttact gaggaagaaa ttgttgacct aagagaaagg cattatgatt ccattgccga      600

aaaacaaaaa gatcttgata agaaaattca aaaagagtta gccttacaag aagagaagtt      660

aagactagaa gaagaagctt tatacgctgc acagcgtgaa gcagccaggg cagcaaagca      720

gcgaaagctc ttggagcaag aaaggcagag aattgtgcag caatatcatc cttccaacaa      780

tggagaatat caaagttcag gaccagaaga tgacttcgaa tcttgtttga gaaatatgaa      840

gtcacagtat gaagtttttc gaagtagtag actctcatca gatgctacag ttttgacacc      900

aaatacagaa agcagttgtg atttaatgac caaaactaaa tcaactagtg gaaatgacga      960

cagcacatcc ttagatctag agtgggaaga tgaagaagga atgaatagaa tgcttccaat     1020

gagagaacgt tccaaaacag aggaagacat tctacgggca gcacttaagt atagcaacaa     1080

gaagactgga agtaatccta catcagcctc tgatgattcc aatgggctgg agtgggaaaa     1140

tgattttgtt agtgccgaaa tggatgataa tggaaattcc gagtattctg gatttgtaaa     1200

tcctgtatta gaactgtctg attctggcat aaggcattct gacacagatc aacagactcg     1260

atagggtaaa attgtgtgac cttgtttatc agttatgacc aaatgttaaa aaccaactag     1320

aatgtataag tgattgtgct tagccttttt gtaagggaga tgtgtaagaa accatgttgt     1380

aaatgcttat tttattacaa aggagtaggg atgataggat ctgaattgat acagaattaa     1440

gtgcaatttc atcatctgcc ttctgctttt caagaccaat ttaatggtcc tgtcatgtta     1500

ctgattaaat ttactttgtc ttgtctttat agcatttctg tttactatgg tagatttcca     1560

ctttcaattt ttaaaattaa ttttactttg aatgatttat gaagcctatt tcattgtcta     1620

actatgaaaa tattaagact tttttgttaa ttctcagccg atgtgaagga agcatgagga     1680

gggatcgtca gattcagatt tagaatagtg ttcccgtttc cagcattatt tatttctatg     1740

acttctttgg attttattat ctaatagtaa gtacagttga tgtgggtaga tgactctaag     1800

aaatgctgaa gtatcggcat tacatgtgtt tatttacatg tcctagtatg ataatgttga     1860

ttcaatctga acaaaagata atataaaaat aacccttcag agtttggaca tttcaagttg     1920

gtaataataa aaaataatat ttaagaagat atatatatat atatatttag ttttttccac     1980

ttcattttac atgccactat attgacttta attgatatac agtattaagt ttttaggtgc     2040

cattattttt aaaaaattct atatttccaa tgaacgatgt tagattttac acagaacata     2100

ttctctgcat gatttcagaa aagaaaatct aaaaaggtaa tacgggtatt tcaaataaaa     2160

tcctttctgg tatgaaaggc tccattgatt ttattaagcc ttcctttacc ttgtagtaca     2220

aggtgcttta atgggataga actaagcata tcaatatcta taactgcatt ttgtgctaga     2280

caattactgt tcttttctct aaaatgtata tgtcaattta caaggccagg gatagaaaac     2340

actccataat tgctttcctt gattttgctg aggatttggt atgattttag taagcaaact     2400

gttttttggt ttttccttaa tgtttttaat tttttttcct cttgcaacaa tgacggtgca     2460

tgttcttata aatataggaa ggtccagata taaatagtaa cctaaagttc ttgctgtgct     2520

taaaaaaaaa aatcatgtgg ccctttcaat atttgaactg ctaagcaatg acatctgtag     2580

ttttatctcc ttttttatgt catagaaatt aatatgatac tttaaatatg taaatataat     2640

acattaggta atgctattat ttatatctgt cttaacataa tttaagttgt agctgtgtct     2700

tggaaatatt tttaaggtaa tctatattca cattgcctgt gttaatgctt tttaaagttt     2760

gtatacatca gatgtatatt tttggtttgg cataagctac gattgtaatt tttcttggct     2820

ttttgttcat aaagaatttt ttgaaggaat ggtaacaaat ggtaatttac aaatggttgt     2880

gaataaacac atttttacac tt                                              2902


<210> 513
<211> 1829
<212> DNA
<213> Homo sapiens

<400> 513
tttctgtggc gcttcccctg cgaggatggc taccctggtt gtaaacaagc tcggagcggg       60

agtagacagt ggccggcagg gcagccgggg gacagctgta gtgaaggtgc tagagtgtgg      120

agtttgtgaa gatgtctttt ctttgcaagg agacaaagtt ccccgtcttt tgctttgtgg      180

ccataccgtc tgtcatgact gtctcactcg cctacctctt catggaagag caatccgttg      240

cccatttgat cgacaagtaa cagacctagg tgattcaggt gtctggggat tgaaaaaaaa      300

ttttgcttta ttggagcttt tggaacgact gcagaatggg cctattggtc agtatggagc      360

tgcagaagaa tccattggga tatctggaga gagcatcatt cgttgtgatg aagatgaagc      420

tcaccttgcc tctgtatatt gcactgtgtg tgcaactcat ttgtgctctg agtgttctca      480

agttactcat tctacaaaga cattagcaaa gcacaggcga gttcctctag ctgataaacc      540

tcatgagaaa actatgtgct ctcagcacca ggtgcatgcc attgagtttg tttgcttgga      600

agaaggttgt caaactagcc cactcatgtg ctgtgtctgc aaagaatatg gaaaacacca      660

gggtcacaag cattcagtat tggaaccaga agctaatcag atccgagcat caattttaga      720

tatggctcac tgcatacgga ccttcacaga ggaaatctca gattattcca gaaaattagt      780

tggaattgtg cagcacattg aaggaggaga acaaatcgtg gaagatggaa ttggaatggc      840

tcacacagaa catgtaccag ggactgcaga gaatgcccgg tcatgtattc gagcttattt      900

ttatgatcta catgaaactc tgtgtcgtca agaagaaatg gctctaagtg ttgttgatgc      960

tcatgttcgt gaaaaattga tttggctcag gcagcaacaa gaagatatga ctattttgtt     1020

gtcagaggtt tctgcagcct gcctccactg tgaaaagact ttgcagcagg atgattgtag     1080

agttgtcttg gcaaaacagg aaattacaag gttactggaa acattgcaga aacagcagca     1140

gcagtttaca gaagttgcag atcacattca gttggatgcc agcatccctg tcacttttac     1200

aaaggataat cgagttcaca ttggaccaaa aatggaaatt cgggtcgtta cgttaggatt     1260

ggatggtgct ggaaaaacta ctatcttgtt taagttaaaa caggatgaat tcatgcagcc     1320

cattccaaca attggtttta acgtggaaac tgtagaatat aaaaatctaa aattcactat     1380

ttgggatgta ggtggaaaac acaaattaag accattgtgg aaacattatt acctcaatac     1440

tcaagctgtt gtgtttgttg tagatagcag tcatagagac agaattagtg aagcacacag     1500

cgaacttgca aagttgttaa cggaaaaaga actccgagat gctctgctcc tgatttttgc     1560

taacaaacag gatgttgctg gagcactgtc agtagaagaa atcactgaac tactcagtct     1620

ccataaatta tgctgtggcc gtagctgttt ttcagataat atgtgaccaa tatactggga     1680

aagaggtagt cacagagaaa gggtaaaagg tcatgctgtt acaggtgtag tttgtgtgca     1740

taaataatac ttccgaatta aattatttaa tatttgactg atttcaataa ctgtgaaaaa     1800

taaaaaaggt gttgtattgc ttgtgagaa                                       1829


<210> 514
<211> 1469
<212> DNA
<213> Homo sapiens

<400> 514
gcggccgcca ttggctgggt tcggcgcagc taacagacgg cggcagtgcg agaaagccga       60

agatggcggt ccccgcggcg ctgatcctac gggagagccc cagcatgaag aaagcagtgt      120

cactgataaa tgcaatagat acaggaagat ttccacggtt gctcactcgg attcttcaaa      180

aacttcacct gaaggctgag agcagtttca gtgaagaaga ggaagaaaaa cttcaagcgg      240

cattttctct agagaaacaa gatcttcacc tagttcttga aacaatatca tttattttag      300

aacaggcagt gtatcacaat gtgaagccag cagctttgca gcagcaatta gagaacattc      360

atcttagaca agacaaagct gaagcatttg tcaatacgtg gtcttctatg ggtcaagaaa      420

cagttgaaaa gttccggcag agaattctgg ctccctgtaa gctagagacc gttggatggc      480

agcttaacct tcagatggct cactctgctc aagcaaaact aaaatctcct caagctgtgt      540

tacaactcgg agtgaacaat gaagattcaa agagcctgga gaaagttctt gtggaattca      600

gtcacaagga gttgtttgat ttctataaca agctagagac tatacaagca cagctggatt      660

cccttacatg atgttttcga agactgtttt tttcatcacg ctcctgccac ctcattattt      720

tgcattgaag atacattgcc aggttgtgtt ttctgaagga ttcagtgact tgctttctgt      780

aaattatatg gcttatcact tcttagacaa ataacaacca atagagatca ttgttaagaa      840

tactgaggtt ctaatatact ttctttagtt ctgtgagcca acagtaatta ttaagaacac      900

tttcccttta aaggaaacaa aagtgaatac catattgttt ttactgtcat agtgttgctt      960

tcttgcctgt cctgcttagt ttttacttgc tggatgatac cataatgtat caaggagcgt     1020

ccatggatac aagataagat gtgtacctta gtagaataca gagctttggt aattacatga     1080

ataaaattaa gaaaatagcc atatacaatc aaatacacta tggcattttt atttgaatat     1140

gatgagtata ttttgcttcg gaaataatat aggaaggaaa tgtaaaatag tgagtagtat     1200

ggtatcagtt aattccagtc tgagcttctc tgtcaacttc agtttctctc tcagtttaat     1260

gatttaataa tagtccaggt ttttgtgtgt ttttctttat actgcaaatt aataatgatt     1320

cactttatag tttgggagac agaatcaggt cttgaataaa ataattgtaa tgagtgctaa     1380

atgggcacca ttattcgaat cagatacctt ttatattctc tttccataaa tacgttgatt     1440

tctgtcaata aaatttttgt gtcttagga                                       1469


<210> 515
<211> 2368
<212> DNA
<213> Homo sapiens

<400> 515
acatgcgcag tagctgtagg agggggtggg cgctccattg ggcgtttctc ttggtttttc       60

ctttccgcgc ggcttgggcg gacgtctcgt gagacgtggg acttctcgcg ggaactgcat      120

tcaaatatcc caggcgctta ctcgagagct agctgagcga atgggccggc gactgtggag      180

ttagcgtcct caatgtggac gccctgagct cccattagga gccgctggct gcggcagcag      240

gggactagcg tgagagttgg ctaaaaaaaa gaaaagaaca tggaggcaga tataatcaca      300

aatcttcgat gcaggctcaa agaggctgaa gaagagcgac taaaagctgc acagtatggt      360

ttacaactag tagagagtca aaatgaatta cagaatcaat tggataaatg tcgtaatgaa      420

atgatgacca tgactgagag ttatgaacaa gaaaaatata cccttcaaag agaagttgaa      480

ctcaagagtc gaatgttaga aagtttgagc tgcgaatgtg aagctattaa acaacaacaa      540

aaaatgcacc tggagaaatt ggaagaacaa ctaagcagaa gccatggaca ggaagtgaat      600

gaactaaaaa ctaagataga aaaactgaaa gtggaattag atgaagccag gcttagtgaa      660

aagcagctga agcaccaagt agatcatcag aaggaactcc tctcttgtaa atcagaggaa      720

ctgcgcgtaa tgtctgaacg tgtgcaggaa agcatgtctt cagagatgct ggctcttcaa      780

attgagctga cagaaatgga gagtatgaag gtcaagtatc agtcactaaa gaagcaaaat      840

gtatttaaca gagaacagat gcagagaatg aagttacaaa ttgccacgtt gctacagatg      900

aaagggtctc aaactgaatt tgagcagcag gaacggttgc ttgccatgtt ggagcagaag      960

aatggtgaaa taaaacatct tttaggtgaa attagaaatc tggagaaatt taagaattta     1020

tatgacagta tggaatctaa gccttcagtc gactctggta ctctggaaga taacacctat     1080

tatacagatt tacttcagat gaagctggat aacttaaaca aagaaattga aagcactaaa     1140

ggtgaattgt ccatacagcg aatgaaagca ttatttgaga gccagcgggc tctagatatt     1200

gagcgaaaac tttttgcaaa tgaaagatgc ctccagcttt cagaaagtga aaatatgaaa     1260

ctgagagcta aactagatga attgaaacta aaatatgaac ctgaagagac agttgaagtg     1320

cctgtactga aaaagaggcg tgaggtgctc cctgtggata taaccaccgc taaagatgca     1380

tgtgtcaaca acagtgctct cgggggagaa gtttatcgat taccgcctca gaaagaggag     1440

acacagtcct gccctaacag tttagaagat aacaacttgc aattagaaaa atcagtttct     1500

atatacacac cagtagtcag tctctctcct cacaaaaatc tgcccgtgga tatgcagctg     1560

aagaaggaaa agaaatgtgt gaaactcata ggagttcccg ctgacgctga ggccttaagt     1620

gaaagaagtg gaaacacccc taactctccc aggttagctg ctgaatcaaa gcttcaaaca     1680

gaagttaaag aaggaaaaga aacttcaagc aaattggaaa aagaaacttg taagaaatta     1740

caccctattc tatatgtgtc ttctaaatct actccagaga cccagtgccc tcaacagtaa     1800

agacttgtct ttaataagag tacggtgcca cttgcctcaa aagttactat ggtgcttaag     1860

attgtcttga tctgacatat atcaccttct gggttattta ctcattgtgc caggacctgg     1920

cattttcatg tgcctttgac caagtgttca gaatttgctt gactctaacc tggagagctt     1980

cttaagtgat gccccttcat ggagcttcta tgacagtgaa taaactatta attgaaggaa     2040

aatgttataa ttaatgtatc tatttgctgc attgtatatg gattaaatga taaaaaacaa     2100

gtaatctacc ctcagagcca tgtatttgag aatgcttcaa tcatattttc ctatgtactt     2160

ttttttataa acttagtttt agactatgtt gtaaaaatgg gaaggttgta aactatgttg     2220

taaaaatagg aaatgtggct taaaatatat acattatatt gtttcaggat tttgtcagtg     2280

tttaaagaac caatgttcat ctttgtattt atatacatga tttaaatttt gtctaaaatt     2340

ttaaataaaa ctgcagtgat ttatcctt                                        2368


<210> 516
<211> 4599
<212> DNA
<213> Homo sapiens

<400> 516
actttgccag agcggccggg tccccattcc cattccttca aatccccttt ttcccggcag       60

ccgacctgta gacccaaggg agacaggttg aagctagaaa gagtcggggc agcagctctg      120

gtaggggagg gagcatccaa aacctctggc ttctgagcgc ctctcctgcc gcccatccac      180

aaagcccccc acagcctggc ggctgccctc gaccccgcaa aacaaaggac ttcagaggct      240

ggacctacag acccagatga gaaggcaaaa gcgtagggag gagcggcagg agatgggaag      300

ggcgggcccc gctcggagca gctgccgctt cctcccaaag tcccacgagg ggcctgagtc      360

acgggccacc gccctgggtc ggcgagctgg gggaagggat ctggacacct ggcgtgtccg      420

ggcgggaagc tggtgagggc ccctggggac agagcggagg accagtggtt ggggcgagaa      480

gagggcagtc ccgcagcgag tcccacgcgg ggtgggaggg atctaggccc cgccctctcc      540

tcggctccgc cctgcgcccc cttccctctc ctcattgtcc ttagacaaag cggtcgccgc      600

ccccgcccgg ccccctggtc tctgtctccg tccctcctcc tttgctgcct ctttccctcc      660

tcctctccct ccctcctccc ctccctccag tctccggatc tccctcggtc cctctctcct      720

cctcttcctc tctctggacg cccggctcct ccgcaccccc tcccccgggg gtcccgcggc      780

ctgtgagttg actgaggggc tcagacttgg ggagtgggtg tctcctcgcc cctgtccttg      840

ctcccgtccc tggcccggac cttggctgtc tcctctttgt gccgagattg tcagtctgtg      900

cggctacagc ggggtggaga cggccggctc tgtcacggct tcatgagagc ggggacgggg      960

cgcaggactt gcaggcgccg gggagaagag acatggagcc ggcccttggc actctggggt     1020

cgcgtggggc agtcggtggg ggaggcaggc ggtggtgaca ggacagggtg ggggtggacg     1080

ccagggttct gggaacgcgc tggcagccct gacgcccggg ttccgaaagt ctcgggggtg     1140

gctatttccc ccgacccgcc tcgggggcgg agtgcggggc agaggggtgg gggctgggga     1200

gaggcgtggc ccgagcggtg ctggaagcgg agccgggacc tttggggccc gcgctgagac     1260

gcgcccggct gctgccgccg ccctcctttc ccctcttccc tggtttccct tctcctctag     1320

acctgttcgc tctccgcccc tccttgcctc cccaacaccc cctcaggtcc cgttgcctcc     1380

tggtcctttc agggattcct ggtccttcct tcccacacta gcctccctgg ggtatcgctg     1440

aggcagcctg gcctgcaccc aggttcccct cacccctgcc acatttctct cttctccctc     1500

acgccaactt tccttttcgc ccttctctct ctttctcaca tcctagagac ggtctttaat     1560

acgcattaac cctgtgctgc cacatctggc tcctgccctc attgcctcca atccggactc     1620

ttcctctcac atcaccccca ccacccccaa cttgggctca caacttctct tcactttttc     1680

catttcccca gttctctgcc ttccgtcttt ccctctgtcc tcatccttag cccctctgcc     1740

ctgctttgtg tcccacctct ccccctccac ttcctctcct cccaccctca gtctcacccc     1800

cgggctgtct cactctctgg agcctctcct tcctgttctc tgtccccagt gctccctacc     1860

ctcacctcaa gacgaccatg gccaccatcc cagactggaa gctacagctg ctagcccggc     1920

gccggcagga ggaggcgtcc gttcgaggcc gagagaaagc agaacgggag cgcctgtccc     1980

agatgccagc ctggaaacga gggctcctgg agcgccgccg ggccaagctt gggctgtccc     2040

ctggggagcc tagccctgtg ctagggactg tagaggctgg acctccagac ccggatgagt     2100

ctgcggtcct tctggaggcc atcgggccag tgcaccagaa ccgattcatc cggcaggagc     2160

ggcagcagca gcagcagcaa caacaacgga gtgaagagct gctagcagag agaaagcctg     2220

ggcctctgga ggcccgggag cggagaccca gccctgggga gatgcgggat cagagcccca     2280

agggaagaga gtcaagagaa gagagactaa gtccgaggga gaccagagag aggaggctgg     2340

ggataggggg agcccaagag ttgagcctga ggcctctgga ggctcgggac tggaggcaaa     2400

gcccaggaga ggtgggagac aggagctccc gactgtcaga ggcatggaaa tggaggctga     2460

gtcctggaga aactccagag cggagtctga gactagcaga gtctcgagag caaagcccca     2520

ggagaaaaga ggtggaaagt agactgagcc caggggaatc tgcctaccag aagttgggcc     2580

tgacagaggc ccataaatgg agacctgact ccagagagtc tcaggaacag agtttggtac     2640

aactggaggc aacagagtgg aggctgaggt caggagaaga aagacaagac tactcggaag     2700

aatgtgggag aaaagaagag tggccagttc caggggtagc tccaaaagag actgcagagc     2760

tgtccgagac cctgacaagg gaggcccaag gcaacagttc cgcaggagtg gaggcagcag     2820

agcagaggcc tgtggaagat ggcgagaggg gcatgaagcc aacagaaggg tggaaatgga     2880

ccctgaactc cgggaaggct cgagaatgga cacccaggga catagaggct caaactcaga     2940

aaccagaacc tccagagtca gcagagaagc ttctggaatc tcccggtgtg gaggctggag     3000

aaggggaggc tgagaaggag gaggcggggg ctcagggcag gcctctgaga gccctgcaga     3060

actgctgctc tgtgccctcc cccctcccac cagaggacgc tgggactgga ggcctgagac     3120

agcaggaaga ggaagcagtg gagctccagc ccccaccacc agcccctctg tctcccccac     3180

ccccagcccc aactgccccc caacctcctg gggatcccct catgagccgc ctgttctatg     3240

gggtgaaggc agggccaggg gtgggggccc cccgccgcag tggacacacc ttcaccgtca     3300

acccccggcg gtctgtgccc cctgcgaccc cagccacccc aacctctcca gccacagttg     3360

atgctgcagt cccgggggct gggaagaagc ggtacccaac tgccgaggag atcttggttc     3420

tggggggcta cctccgtctc agccgcagct gccttgccaa ggggtccccc gaaagacacc     3480

acaaacagct taagatctcc ttcagcgaga cagccctgga gaccacgtac caatacccct     3540

ccgagagttc ggtactggag gagctgggcc cggagcctga ggtccccagt gcccccaacc     3600

ctccagcagc ccaacccgac gacgaagagg atgaggaaga gctgctgctg ctgcagccag     3660

agctccaggg cgggctgcgc accaaggccc tgattgtgga tgagtcctgc cggcggtgac     3720

catcttccaa catagggata tacctccctc cttcttataa ctgaagatcc tggagcccgg     3780

aagattcagg gcagacagac cctgataatg agcctggcag ggaagggcaa ccaacatctt     3840

gtaacttgct ttccccaccc tgtttctggg ggcagagcca attgcccaat ttctacccta     3900

atccaaagtc cctggtgtgg gtggggttaa acgtgctggt gcatcctagg tcatccaaga     3960

gtgagcgcca agtcctgaga aggggcacag aactccctgg agggtggaga tggagcacct     4020

gccccccatg gcagggtaca ctctccccac agccttcctc cccaccatcc cgtggggact     4080

ctcgggattt aagcactcgt ctctctggga ggcccagacc ccactccatt tataggcaca     4140

tctccttcat ttcctaggtc actgcccctt tgtttacagc tcctgcctcc tcccttgacc     4200

acagcctggt ttacaaattc catcagctcc cagccccacc tgccaaagtc ccaggtttac     4260

aagccacgct tacttgctgt gtctgcgtgg aattctctcc tctgtcccct ccagtctcct     4320

cattggagtg acctgaaggt gtggcttcct ccactttttc tcagtattac tttgccttag     4380

ttttccccaa gagggaaggc tggaactctt aactctgtac cccttgatag ttatttaatt     4440

ctgtttctcc tagtggttca caattgaact gaattgagat ggtgtcgggt ggctaaggag     4500

acacctcacc tctccttccc cattgtgccg cctttatcaa ttgcctgttt tgttttgttt     4560

gttttttaac tttccataat aaaatggagt tctcttcaa                            4599


<210> 517
<211> 800
<212> DNA
<213> Homo sapiens

<400> 517
gagctatgag ctggacctgt ccgcgttgcc agcaacctgt tttcttcgct gagaaggtga       60

gctccctggg caagaactgg caccgcttct gcctgaaatg tgagcgctgc cacagcatcc      120

tgtcccctgg cgggcatgca gagcacaatg ggaggccata ctgccacaag ccatgctatg      180

gggctctctt tggacccagg ggggtgaaca ttggtggtgt aggctcctac ttgtacaatc      240

cccccactcc cagccctggc tgcaccactc ctctcagccc cagcagcttc agccctccca      300

ggccaaggac tggcctcccc caaggcaaga aaagccctcc ccatatgaag acattcactg      360

gggagacctc gctgtgccct ggctgtgggg agcccgtcta ttttgctgag aaggtgatgt      420

cattaggcag aaattggcac cgaccgtgtc tgaggtgcca gcgttgccac aagaccctga      480

ctgctgggag tcatgctgag catgatggag tcccctactg ccacgtcccc tgctacggct      540

acctgtttgg ccccaaaggt gggcagcccc atcccagaca ctgggatggc atgtacatgc      600

ctgaagtatg gcatgtacat ggtctgtggg tatgtgtgga caacttcccc tgtggttaag      660

cataccctgg cccccccacc aagttccctc taggcctgaa ccctgcacca cagacccagg      720

gcctttggtg atagggctct ctctctcagg tgtgaacatt ggcgatgtgg gctgctacat      780

ctatgaccca gtgaagataa                                                  800


<210> 518
<211> 2540
<212> DNA
<213> Homo sapiens

<400> 518
atgaatcaac gaaggagtga gtcaaggccc gggaaccaca gactccaagc ctacgcagag       60

cccgggaagg gggattccgg aggggcgggg cctctttccg gaagcgcccg ccgggggcgg      120

ggagggggcg gggccatccg cgtgaggcga ccctgttggt ccggaggggc ggggcgagga      180

ggaggacccg cttgggcggt tcggctgccc acagtaaccg ctgggtggac ctggccagcg      240

ctccgaacct tgtcctcgct gcgcgccggc ccctcggagc cccacagccc gggaaggagg      300

ccgccgcggg ccgggcgccc gctctgccaa gcggacccgc aacccggaaa ggcggcgcgg      360

cggagcctgg agccggatcc tgctcagacc gggccccggc cggccagagc cgcgggcatg      420

tcggaggcgc ggaaggggcc ggacgaggcg gaggagagcc agtacgactc tggcattgag      480

tctctgcgct ctctgcgctc cctacccgag tccacctcgg ctccagcctc cgggccctcg      540

gacggcagcc cccagccctg cacccatcct ccgggacccg tcaaggaacc acaggagaag      600

gaagacgcgg atggggagcg ggctgattcc acctatggct cctcctcgct cacctacacc      660

ctgtccttgc tggggggccc cgaggctgag gacccggccc cacgcctgcc actcccccac      720

gtgggggcgc tgagccctca gcagctggaa gcactcactt acatctccga ggacggagac      780

acgctggtcc acctggcagt gattcatgag gccccagcgg tgctgctctg ttgcctggct      840

ttgctgcccc aggaggtcct ggacattcaa aataaccttt accagacagc actccatctg      900

gctgtacatc tggaccaacc gggcgcagtt cgggcactgg tgctgaaggg ggccagccgg      960

gcactacagg accggcatgg tgacacagcc cttcatgtgg cctgccagcg ccagcacttg     1020

gcctgtgccc gctgcctgct ggaagggcgg ccagagccag gcagaggaac atctcactct     1080

ctggacctcc agctgcaaaa ctggcaaggt ctggcttgtc tccacattgc cacccttcag     1140

aagaaccaac cactcatgga attgctgctt cggaatggag ctgacattga tgtgcaggag     1200

ggcaccagtg gtaagacagc gctgcacctg gctgtggaaa cccaagagcg gggcctggta     1260

cagttcctgc tccaggctgg tgcccaggta gatgcccgca tgctgaacgg gtgcacaccc     1320

ctgcacctgg cagctggccg gggtctcatg ggcatctcat ccactctgtg caaggcgggt     1380

gctgactccc tgctgcggaa tgtggaggat gagacgcccc aggacctgac tgaggaatcc     1440

cttgtccttt tgccctttga tgacctgaag atctcaggga aactgctgct gtgtaccgac     1500

tgaagccagg cagggtctgg gatcctcagg gctccacctc tccatctgga agccggagcc     1560

ataactgctg cagtttgggc ccaggctatg tgctcttctg gtgccctagg gactgctgtg     1620

gccagagcct ggggccagcc agtacagtcc tgagccgagg aggagggact gcaagtggaa     1680

gagagccagt ctggaaggaa gagctttcca ggtggacagg gcttcttgga agacccccaa     1740

agccccaggt atcctgggtg aagcctgttt gcctctcttg aaaatggcag gtgctcttgt     1800

tttacccatg ttgggtcagc ctgaaactgc caaccagtag gaagcatgga ctctcctgag     1860

tgagaagaga ctgaaatagg agcaagcaga accctgagag gtgtcccatc ttattgctgt     1920

tgaggaccct gaaacaccgt tgtttaaaga cttcacacag aaggctctga actgagccac     1980

tggggaaggg aagtttcagt aacatgacac taaaatggca gagacgttaa aaaaagtttt     2040

tcccttctag agctgttttg cgcgcatgca tgtctgtgtg cattggggct ttttagacag     2100

gcctgccctg tgactttgtg gtagaggcag agagaaggaa attgtcccct gagcacggta     2160

gggccttgct gggtggggtc agaggccagt agttccaggc ctttctctgt gtccagcaca     2220

gacccttgtc cttgctgtgg aaatgatgag ggatggaggg acaagaggaa gaatgagagg     2280

acacacgccc tggagccctc accactgccc tgggggttgc catctggagg agcctgggga     2340

taagggtaac ccagggaggc tgggcacgag ggagctgact ccacgttttt ccccccgttc     2400

ctcaccttcg agggccctgc taggtcaccc ctatgctggc atgaagagca tggggcaata     2460

aaccagcaca gtctctgacc acttggagcg tctcatccag tgagagagac agccgttaaa     2520

agcataaaca tccaaataaa                                                 2540


<210> 519
<211> 2491
<212> DNA
<213> Homo sapiens

<400> 519
acaatgtccc tttgggtgag gaggttgaaa gagtttttgg tttgttctgg gaacttaagg       60

tatattaagc agtccccaca gacatgctgc ctgcactcca cctgctgagc tggctctgag      120

gctcaggaga cgtggccctc tgtggtccca ttgtctccac gtctgtggta acccggtgcc      180

tttctagagc aggcaggctc ccggcatggg tggaaacaga gcagggggcc agcttccccc      240

aatcaccggt gctgctgtgg aggaagagct tggtggcgct aggacgtcct tgtgaatgtg      300

acttggaaga gcagtttggg atttttttca ttgcctgggg atgagaggga gagacaacgt      360

gtgtcttaca catctcccaa cagccgactt agatgtgatc cgttctccca gagggagcag      420

gtttctttga acttttcctt tttatgtaca gcatagtgct gagcagatca ctgcactgtg      480

caggagtttt aacgacagtc aggccaacgg catggaagga ccgcgggaga atcaggatcc      540

tcctccgagg tctctggccc gccacctgtc tgatgcagac cgcctccgca aagtcatcca      600

ggagcttgtg gacacagaga agtcctacgt gaaggatttg agctgcctct ttgaattata      660

cttggagcca cttcagaatg agacctttct tacccaagat gagatggagt cactttttgg      720

aagtttgcca gagatgcttg agtttcagaa ggtgtttctg gagaccctgg aggatgggat      780

ttcagcatca tctgacttta acaccctaga aaccccctca cagtttagaa aattactgtt      840

ttcccttgga ggctctttcc tttattacgc ggaccacttt aaactgtaca gtggattctg      900

tgctaaccat atcaaagtac agaaggttct ggagcgagct aaaactgaca aagccttcaa      960

ggcttttctg gacgcccgga accccaccaa gcagcattcc tccacgctgg agtcctacct     1020

catcaagccg gttcagagag tgctcaagta cccgctgctg ctcaaggagc tggtgtccct     1080

gacggaccag gagagcgagg agcactacca cctgacggaa gcactaaagg caatggagaa     1140

agtagcgagc cacatcaatg agatgcagaa gatctatgag gattatggga ccgtgtttga     1200

ccagctagta gctgagcaga gcggaacaga gaaggaggta acagaacttt cgatgggaga     1260

gcttctgatg cactctacgg tttcctggtt gaatccattt ctgtctctag gaaaagctag     1320

aaaggacctt gagctcacag tatttgtttt taagagagcc gtcatactgg tttataaaga     1380

aaactgcaaa ctgaaaaaga aattgccctc gaattcccgg cctgcacaca actctactga     1440

cttggaccca tttaaattcc gctggttgat ccccatctcc gcgcttcaag tcagactggg     1500

gaatccagca gggacagaaa ataattccat atgggaactg atccatacga agtcagaaat     1560

agaaggacgg ccagaaacca tctttcagtt gtgttgcagt gacagtgaaa gcaaaaccaa     1620

cattgttaag gtgattcgtt ctattctgag ggagaacttc aggcgtcaca taaagtgtga     1680

attaccactg gagaaaacgt gtaaggatcg cctggtacct cttaagaacc gagttcctgt     1740

ttcggccaaa ttagcttcat ccaggtcttt aaaagtcctg aagaattcct ccagcaacga     1800

gtggaccggt gagactggca agggaacctt gctggactct gacgagggca gcttgagcag     1860

cggcacccag agcagcggct gccccacggc tgagggcagg caggactcca agagcacttc     1920

tcccgggaaa tacccacacc ccggcttggc agattttgcc gacaatctca tcaaagagag     1980

tgacatcctg agcgatgaag atgatgacca ccgtcagact gtgaagcagg gcagccctac     2040

taaagacatc gaaattcagt tccagagact gaggatttcc gaggacccag acgttcaccc     2100

cgaggctgag cagcagcctg gcccggagtc gggtgagggt cagaaaggag gagagcagcc     2160

caaactggtc cgggggcact tctgccccat taaacgaaaa gccaacagca ccaagaggga     2220

cagaggaact ttgctcaagg cgcagatccg tcaccagtcc cttgacagtc agtctgaaaa     2280

tgccaccatc gacctaaatt ctgttctaga gcgagaattc agtgtccaga gtttaacatc     2340

tgttgtcagt gaggagtgtt tttatgaaac agagagccac ggaaaatcat agtatgattc     2400

aatccagata tgggttaaat tcctcatttt acttttaaac tggtggtaaa gtggaaattg     2460

caaaaaaaaa aaaaaaaaaa aactgttcat t                                    2491


<210> 520
<211> 2719
<212> DNA
<213> Homo sapiens

<400> 520
caaggccgag gcgcgaaggg tgggaccgca ggagccgtgc agccgcggac caatgagcgg       60

gcgccggacg acctgtggcc caatggcggc ggcgcgcggg cacgctgggg gccggccaga      120

cgggccgact tttccagaag acccggatag ttcctcccgg ccacgccgcg ccggctctgg      180

gcactcagca tcgtttcctt ttcctccgct ggagcagcta tggcggcggt gaagaccctg      240

aaccccaagg ccgaggtggc ccgagcgcag gcggcgctgg cggtcaacat cagcgcagcg      300

cggggtctgc aggacgtgct aaggaccaac ctggggccca agggcaccat gaagatgctc      360

gtttctggcg ctggagacat caaacttact aaagacggca atgtgctgct tcacgaaatg      420

caaattcaac acccaacagc ttccttaata gcaaaggtag caacagccca ggatgatata      480

actggtgatg gtacgacttc taatgtccta atcattggag agctgctgaa acaggcggat      540

ctctacattt ctgaaggcct tcatcctaga ataatcactg aaggatttga agctgcaaag      600

gaaaaggccc ttcagttttt ggaagaagtc aaagtaagca gagagatgga cagggaaaca      660

cttatagatg tggccagaac atctcttcgt actaaagttc atgctgaact tgcagatgtc      720

ttaacagagg ctgtagtgga ctccattttg gccattaaaa agcaagatga acctattgat      780

ctcttcatga ttgagatcat ggagatgaaa cataaatctg aaactgatac aagcttaatc      840

agagggcttg ttttggacca cggagcacgg catcctgata tgaagaaaag ggtggaggat      900

gcatacatcc tcacttgtaa cgtgtcatta gagtatgaga aaacagaagt gaattctggc      960

tttttttaca agagtgcaga agagagagaa aaactcgtga aagctgaaag aaaattcatt     1020

gaagataggg ttaaaaaaat aatagaactg aaaaggaaag tctgtggcga ttcagataaa     1080

ggatttgttg ttattaatca aaagggaatt gacccctttt ccttagatgc tctttcaaaa     1140

gaaggcatag ttgctctgcg cagagctaaa aggagaaata tggagaggct gactcttgct     1200

tgtggtgggg tagccctgaa ttcttttgac gacctaagtc ctgactgctt gggacatgca     1260

ggacttgtat atgagtatac attgggagaa gagaagttta cctttattga gaaatgtaac     1320

aaccctcgtt ctgtcacatt attgatcaaa ggaccaaata agcacacact cactcagatc     1380

aaagatgcag tgagggacgg cttgagggct gtcaaaaatg ctattgatga tggctgtgtg     1440

gttccaggtg ctggtgccgt ggaagtggca atggcagaag ccctgattaa acataagccc     1500

agtgtaaagg gcagggcaca gcttggagtc caagcatttg ctgatgcatt gctcattatt     1560

cccaaggttc ttgctcagaa ctctggtttt gaccttcagg aaacattagt taaaattcaa     1620

gcagaacatt cagaatcagg tcagcttgtg ggtgtggacc tgaacacagg tgagccaatg     1680

gtggcagcag aagtaggcgt atgggataac tattgtgtaa agaaacagct tcttcactcc     1740

tgcactgtga ttgccaccaa cattctcttg gttgatgaga tcatgcgagc tggaatgtct     1800

tctctgaaag gttgaattga agcttcctct gtatctgaat cttgaagact gcaaagtgat     1860

cctgaggatt acagctgtgg aatttttgtc caagcttcaa ataattttga aagaaatttt     1920

cccatatgaa aaaaggagag aacactggca tctgttgaaa tttggaagtt ctgaaattat     1980

agtattttta aaaattgcac tgaagtgtat acacataaag caggtctttt atccagtgaa     2040

caggatgttt tgctttagca gcagtgacat aaaattccat gttagataag catatgttac     2100

ttaccttgtt attaaatatt tcttgaaaag caaattttaa tggtttaatt ttatgtggac     2160

gtatgttaaa ttatccaact accctattgt taagcatttg gttttaaaat ttttatgcta     2220

atataaatgc tcaagtaatt taaaatattg aaagcatccc tgttggtata aatttctgag     2280

taaatgcatt ggatcagttg gactttgaac gcctttgaaa tggctttgct aaaatgctcc     2340

cgccacaaag ttgtaggaaa tgggaagagg agtcaactag aggcaaggga gttgagagag     2400

ctgcaactgt aaagggcaag aacaggcaga ggtaaaaaga tgatggaagg tgtggtgact     2460

aagggccacg gttattgggt gaaatttgag attgtaggcc aactgtattt tcaagcttct     2520

gaacttaggc aaaatattca tcgcaaagtc tctagcgtca tatttttctc acccaaatta     2580

cgtttccacg agattattta tatatagttg gtctatctct gcagtccttg aaggtgaagt     2640

tgtgtgttac taggctgtgt tttgggatgt cagcagtggc ctgaagtgag ttgtgcaata     2700

aatgttaagt tgaaacctc                                                  2719


<210> 521
<211> 1071
<212> DNA
<213> Homo sapiens

<400> 521
caggctgagc gttggaagcc attttggctg caacctacct gaagcgatgt ctgcctttgg       60

tcacgacgag gcctggatgg aggccggagg ctttggtctg gaggctgccg aaagaacgga      120

ataccagtct ctgtgcaaat ctaaactctt attcctggga gagcagagcg ggaagacatc      180

catcatcagc cgcttcatgt acaacagctt cggctgcgcc tgccaggcaa ctgttggaat      240

tgacttcttg tctaagacca tgtacttgga ggaccaaata gttcagctgc agctatggga      300

cacagctggc caggagcgct ttcacagcct aattcctagc tacattcgtg attcaactat      360

tgcagtggtt gtctatgaca ttacaaacat caattctttt aaggagacag ataagtgggt      420

agaacacgtg cgagcagaaa gaggtgacga tgttgtcatc atgttgttgg gtaacaagat      480

tgatttggat aacaaaagac aagtcactgc agaacagggt gaagaaaaat ccagaaacct      540

caatgtgatg tttattgaga ccagtgccaa aaccggttac aacgtgaaaa agctgttccg      600

gcgtgtggct tctgcccttc tttccacaag gacttcacct ccaccaaaag aggggacggt      660

tgaaatcgaa ctggaatcct tcgaggagtc aggcaacaga agctattgtt gacagcttag      720

gctttctctg cctcatttga tggatttctt acatttgggc ttgccatacc agttctcctc      780

cccacctcgt tttatgatac atggccactt actctcttcc aattcctagg cttggggtaa      840

aaacagaacc cctgaaagtg ctatcatttt ttcctgaccg catctcacag ctactgggtg      900

gaagcttctt gcagcacctg ggaattctac cttaccttct ccgacagcta aaagacatct      960

gtagagaata cagttctaca gcagctgaca tacttcaaag gccaatacaa ttcattctcc     1020

actgtttgtt gttgtttacc tacaccctca ataaatggtt ctttaaccta a              1071


<210> 522
<211> 6625
<212> DNA
<213> Homo sapiens

<400> 522
gcagtgagtc cacccgcccg ccgaggtccg cccgcccgcc gagacccgcc cgccgccgct       60

gccatggccg aagtgcgcaa attcaccaaa cggctcagca agcctggcac ggcggctgag      120

ctccggcaga gcgtgtctga ggccgtgcgg ggctccgtgg tgctggaaaa ggccaaagtt      180

gttgagcccc tggactatga gaatgttatt gcccaaagaa aaacccagat ttacagcgac      240

cccctccgag atctgcttat gttcccaatg gaagatatat ctatctcggt gataggtcgt      300

caacgcagaa cggtgcagtc tactgtacca gaagatgctg aaaagagggc ccagagttta      360

tttgttaaag agtgtattaa aacctatagc acagattggc acgtggtaaa ctacaagtat      420

gaggacttct ctggggactt tcgaatgttg ccatgtaaat ctttgagacc agaaaagatt      480

cctaatcatg tatttgagat agatgaagac tgtgagaaag atgaggactc atcttcttta      540

tgttctcaga agggtggtgt gataaaacaa ggctggttgc ataaagcaaa tgtaaatagt      600

accatcacag taaccatgaa ggtattcaag agacgatatt tttacttgac ccaacttcct      660

gacggttcat atattctcaa ttcctataaa gatgagaaaa attcaaaaga atcgaaaggt      720

tgcatctact tggacgcctg cattgatgtt gttcagtgcc ccaaaatgcg ccgtcatgct      780

tttgaactca agatgttaga taaatatagc cattatctgg ctgctgaaac tgagcaggaa      840

atggaggaat ggttgataac tttgaaaaag attattcaga tcaacaccga cagtttagtt      900

caagaaaaaa aggagacggt agaaacagca caagatgatg aaactagcag ccaaggaaaa      960

gccgagaaca tcatggcaag tttggaaagg agcatgcatc cggaactgat gaagtatgga     1020

agagaaactg aacaactaaa caaactcagt agaggagatg gaagacagaa tctcttttct     1080

tttgattcag aagttcagag gttggacttt tcaggaattg aacctgatat aaagccattt     1140

gaagaaaaat gcaataaacg tttcctggtg aattgccatg atttaacttt caatatcttg     1200

ggccaaattg gagacaatgc aaaaggacca cccacaaatg ttgagccctt ttttatcaat     1260

cttgccttat ttgatgtaaa gaacaattgt aagatttcag cagactttca tgtagacctg     1320

aatcccccat ctgtccgtga aatgctgtgg ggctcttcaa cccaactggc cagtgacggt     1380

agcccaaagg gctcttcacc cgaatcttac attcatggaa ttgccgaatc tcagttacgc     1440

tacatacaac agggaatttt ctcagtgacg aatccacatc ctgaaatttt tctagttgcc     1500

agaattgaaa aggtactaca gggaaacatt acacactgtg cagaacccta tatcaaaaat     1560

tctgatccag taaagacggc ccagaaggtg cacaggacag ctaaacaagt gtgtagccgc     1620

cttggacaat acagaatgcc cttcgcttgg gctgccagac ccattttcaa agatactcaa     1680

ggctctcttg atctggatgg gagattttct cctctgtata aacaagacag tagcaagctt     1740

tcaagtgaag acattctcaa gttgctctca gaatataaga agccagaaaa gaccaaactg     1800

cagattattc ctgggcagct aaacatcaca gtagaatgtg ttcctgtgga tttatcaaat     1860

tgtattactt cttcatatgt gcccttgaag ccttttgaaa agaattgcca aaatattact     1920

gtggaggttg aagagtttgt tccagaaatg acaaaatatt gttatccatt tactatttac     1980

aaaaaccatc tgtatgtata tcccctgcaa ttaaaatacg atagccagaa aacatttgcc     2040

aaggcaagga acattgcagt ctgtgtggaa ttccgggatt cagatgaaag tgacgctagt     2100

gccctaaagt gtatttatgg aaaacctgca gggtctgttt ttaccacaaa tgcttatgct     2160

gttgtctcgc atcacaacca aaatccagag ttctatgatg agattaaaat tgagcttccc     2220

attcacctac atcaaaaaca tcatttgctt ttcacttttt atcatgtaag ttgtgaaatt     2280

aacacaaagg gaacaaccaa aaagcaagac acagttgaaa ctccagttgg gtttgcctgg     2340

gtacctttgc tgaaagatgg tagaatcatc acatttgagc agcagctgcc agtttccgcc     2400

aatcttcccc caggctactt gaatctgaat gatgcagaat caagaaggca atgtaacgtg     2460

gatattaaat gggtagatgg tgcaaagcct ttgttgaaga ttaaaagcca cttagaatct     2520

accatttaca ctcaagatct gcatgtgcac aaattcttcc atcattgcca gctgattcag     2580

tcaggctcga aagaagttcc aggggagctc attaaatatt taaagtgttt gcatgccatg     2640

gagatccaag tcatgataca gtttctacct gtaattctta tgcaactctt ccgagttctc     2700

acaaatatga cccatgaaga tgacgttcct atcaactgca ccatggttct cttacatatt     2760

gtatcaaagt gccatgaaga aggcttggat agttatctaa gatcattcat aaagtatagc     2820

ttccgacctg aaaaaccgag tgctcctcag gcccagctga tacatgaaac cctggctact     2880

acgatgatag caatattgaa acagtctgca gattttttat caataaacaa attgctaaag     2940

tactcatggt ttttctttga aataattgca aagtcaatgg ccacatactt gttggaagag     3000

aataagatta agcttccccg aggccagaga tttcccgaga catatcatca tgtcttacat     3060

tcactgcttc ttgcaataat tccccatgtg actattcggt atgcggagat tcccgatgag     3120

tccagaaatg tgaactatag tttggctagc ttcctgaagc gctgtttgac actaatggat     3180

agaggattta ttttcaattt aataaatgac tatatatctg gattcagccc caaagatcct     3240

aaggttctgg ctgaatacaa gtttgaattt ctgcaaacaa tttgcaatca cgaacattac     3300

attcctctga acttgccaat ggcatttgca aaacctaaac tgcagcgggt tcaagattca     3360

aatcttgaat acagtttatc agatgagtat tgcaagcatc acttcttggt tggtctactt     3420

ctgagggaaa cttccattgc tcttcaggac aattatgaga tcagatatac agctatctct     3480

gttataaaga atcttttgat aaaacatgca tttgacacaa gataccagca caagaaccaa     3540

caagccaaaa tagcacaatt gtacctcccc tttgttggac tacttttgga aaatatacag     3600

cgattagcag gtcgagatac cttgtattct tgtgcagcca tgcctaattc tgcatccaga     3660

gatgagtttc catgtggctt tacttcacct gccaatagag ggagtctgag cactgacaaa     3720

gacaccgctt atgggtcttt tcaaaatgga catggaatta agagagaaga ttcaagaggt     3780

tccctcatcc cagaaggagc aacaggattt ccagatcagg gcaacactgg tgaaaatacc     3840

cgacagagtt ctacaaggag tagtgtatcc cagtataacc gcctggatca gtatgaaatc     3900

agaagcctcc tgatgtgcta cctgtatata gtaaaaatga tttcagaaga tactctctta     3960

acttactgga ataaagtatc acctcaggag ctcataaaca ttcttatact tttagaagta     4020

tgcttgtttc actttagata tatggggaaa agaaacatag caagggtgca tgatgcctgg     4080

ctgtcaaaac acttcggaat agaccgaaaa tcgcaaacca tgcctgctct tcgaaacaga     4140

tcaggagtaa tgcaggcccg gcttcagcat cttagtagcc tagaaagttc atttacactt     4200

aatcacagtt ctacaacaac tgaagcagac attttccacc aggcacttct tgaaggcaat     4260

acagctactg aagtttccct aacagtacta gacaccatat catttttcac tcagtgcttc     4320

aagacccaac ttttaaataa tgatggccat aacccattaa tgaaaaaagt gtttgatata     4380

catcttgctt ttcttaaaaa tggacaatct gaagtgtcgc tgaaacatgt atttgcctca     4440

ctgagagctt tcatcagtaa gtttccttca gcatttttca aaggaagagt aaacatgtgt     4500

gctgcatttt gctatgaggt tttaaagtgc tgcacatcga agattagctc aaccaggaat     4560

gaagcatctg cacttttgta tcttttgatg agaaacaact ttgagtatac caaaaggaaa     4620

acctttttga ggacacatct acagataata attgctgtaa gccaactgat agctgatgta     4680

gcactaagcg gaggatcaag atttcaggag tctttattca ttatcaataa ttttgcaaat     4740

agtgacagac ctatgaaggc aactgccttt cccgcagaag tcaaagactt gaccaagaga     4800

atccgcactg ttcttatggc cactgcccaa atgaaggagc atgagaaaga ccctgaaatg     4860

ctaattgatc tccagtatag cttagccaag tcctatgcaa gcaccccaga gctcaggaaa     4920

acctggcttg atagcatggc caagattcat gtaaaaaatg gagatttttc agaggctgcg     4980

atgtgttatg tccatgtagc agctctagtt gcagagtttc ttcatcgaaa aaaattattt     5040

cctaacggat gttcagcgtt caagaaaatt actcccaata tagatgaaga aggagcaatg     5100

aaagaagatg ctgggatgat ggatgtccat tatagtgaag aggtcttgct ggagttgcta     5160

gaacaatgtg tggatggctt atggaaggca gaacgttatg aaataatttc tgagatttcc     5220

aagttgatcg ttccaattta tgagaaacgt cgtgagtttg agaaacttac tcaagtttat     5280

agaactcttc atggagctta cacaaaaatt ctggaagtta tgcatacaaa aaagagactt     5340

ttaggcactt tcttcagagt tgccttttat ggccaatctt tttttgaaga agaagatgga     5400

aaggagtaca tctataaaga accaaagctc actggcctct cagaaatttc cttgagactt     5460

gttaaacttt atggtgaaaa gtttggtacg gagaatgtca aaataattca ggattcagac     5520

aaggtaaatg ccaaagagct tgatccaaaa tatgctcata tacaagttac ttatgtgaag     5580

ccttactttg atgacaaaga actcacagaa aggaagaccg agtttgaaag aaatcataat     5640

atcagcagat ttgtttttga ggccccttac actttatcag gcaaaaaaca gggctgtata     5700

gaagaacagt gcaaacgccg tacaatcttg acaacttcaa actcgtttcc ttacgtgaag     5760

aagaggattc ctattaactg tgaacagcag attaatttaa aaccaattga tgttgccact     5820

gatgaaataa aagataaaac tgcagagctg caaaagcttt gctcctctac tgacgtggac     5880

atgattcagc tccaacttaa attgcagggc tgtgtttctg tgcaggtcaa tgctggtcca     5940

ttagcatatg caagagcttt cttaaatgac agccaagcta gcaagtatcc acctaagaaa     6000

gtgagtgagt tgaaagacat gtttaggaaa tttatacaag catgcagcat tgcacttgaa     6060

ctaaatgagc ggctaattaa agaagatcaa gttgagtacc atgaagggct aaagtcaaat     6120

ttcagagaca tggtaaaaga attatctgac attatccatg agcagatatt acaagaagac     6180

acaatgcatt ctccctggat gagcaacaca ttacatgtat tttgtgcaat tagtggtaca     6240

tcaagtgacc gaggttatgg ttccccaaga tacgctgaag tgtgaggaaa tgcagatgta     6300

cgtgacaatg agactgacct ttctcaggaa tatttggagc tgtgcaaatg ttaaaattta     6360

aagatttgat atacatggag tgtttcttct cgacaccaaa attttcatgt gttccaacag     6420

ggtgcttaca tatttgtaaa taagcaactt gaaagtgcct ggaaaattgc accactgtgc     6480

ttggtttgta cttttttagg taaatctata tgctgaaaag tagagctcaa aaacagtagt     6540

tcaatttgct taattattgc ttaaaataat ggtactatgt aaaattgtat aatggaatac     6600

aataaaaggt aaaacttatt tgtaa                                           6625


<210> 523
<211> 3083
<212> DNA
<213> Homo sapiens

<400> 523
atgctcgagg tgtccggtga ccgaaacact cttagctggg tgcagggtgc ggctcagggc       60

gtggtcaccg ggggctactt agggccgccg gtgcggggga cgacgcaaag gttaactgcg      120

agctgccggg cactcagcgc gggtcatggc gtggatactg gactgccttt tcgcctcggc      180

ctttgagccc cgcccccgcc gtgcaaaaac aaccagaggc tgctctgctt gagggtgaag      240

ccgcctccca gttttccctc cccctctacc cccaccccca tagttctctc caccaggtcc      300

agtgacaatt ggatgatgca gccttgataa tcatccgatt ccagaatggg tggctgcatt      360

ccttttctga aggcagcaag ggcactgtgc cccagaatca tgcccccttt gctgttgttg      420

tccgccttca tttttttagt gagtgtcttg ggaggagccc caggacacaa ccccgaccgc      480

aggacgaaga tggtatcgat acacagcctc tctgagctgg agcgtctgaa gctgcaagag      540

actgcttacc acgaactcgt ggccagacat ttcctctccg aattcaaacc tgacagagct      600

ctgcctattg accgtccgaa caccttggat aagtggtttc tgattttgag aggacagcag      660

agggctgtat cacacaagac atttggcatt agcctggaag aggtcctggt gaacgagttt      720

acccgccgca agcatcttga actgacagcc acgatgcagg ttgaagaagc caccggtcag      780

gctgcgggcc gtcgtcgggg aaacgtggtg cgaagggtgt ttggccgcat ccggcgcttt      840

ttcagtcgca ggcggaatga gcccaccttg ccccgggagt tcactcgccg tgggcgtcga      900

ggtgcagtgt ctgtggatag tctggctgag ctggaagacg gagccctgct gctgcagacc      960

ctgcagcttt caaaaatttc ctttccaatt ggccaacgac ttctgggatc caaaaggaag     1020

atgagtctca atccgattgc gaaacaaatc ccccaggttg ttgaggcttg ctgccaattc     1080

attgaaaaac atggcttaag cgcagtgggg atttttaccc ttgaatactc cgtgcagcga     1140

gtgcgtcagc tccgtgaaga atttgatcaa ggtctggatg tagtgctgga tgacaatcag     1200

aatgtgcatg atgtggctgc actcctcaag gagtttttcc gtgacatgaa ggattctctg     1260

ctgccagatg atctgtacat gtcattcctc ctgacagcaa ctttaaagcc ccaggatcag     1320

ctttctgccc tgcagttgct ggtctacctg atgccaccct gccacagtga taccctggag     1380

cgtctgctga aggccctgca taaaatcact gagaactgcg aggactcaat tggcattgat     1440

ggacagttgg tcccaggcaa ccgtatgact tccactaact tggccttggt gtttggatct     1500

gctctcctga aaaaaggaaa gtttggcaag agagagtcca ggaaaacaaa gctggggatt     1560

gatcactatg ttgcttctgt caatgtggtc cgtgccatga ttgataactg ggatgtcctc     1620

ttccaggtgc ctccccatat tcagaggcag gttgctaagc gcgtgtggaa gtccagcccg     1680

gaagcacttg attttatcag acgcaggaac ttgaggaaga tccagagtgc acgcataaag     1740

atggaagagg atgcactact ttctgatcca gtggaaacct ctgctgaagc ccgggctgct     1800

gtccttgctc aaagcaagcc ttctgatgaa ggttcctctg aggagccagc tgtgccttcc     1860

ggcactgccc gttcccatga cgatgaggaa ggagcgggta accctcccat tccggagcaa     1920

gaccgcccat tgctccgtgt gccccgggag aaggaggcca aaactggcgt cagctacttc     1980

tttccttaga tgtttttcct tctataaggt gccagacagg ggaaaagggt gggggtacat     2040

ctgggatgtc acaggaaaca ttaaggagag agttgaaggt aaagatctga aggtaagaag     2100

gagttccacc tgatgctcgg gtcaggatga gaattccaaa cacactgcca gccccttcac     2160

tggggatgct tggtctcttc tgctggtaaa agcagagatg tttctgtgtc atgcccaagc     2220

tccccggtgc taccttgcct ttctctttta cccctgatct tggctttctc tctctctctg     2280

cagactttcc tttaattgat gtgacatttg tggtaaacac ctttcccagg gaacctcaca     2340

aatcttgaga tgctttccct tccccagatg ggattgcatg atttccctga ctttcctacc     2400

ctcctccaga gagctcagtt ggaaaggccc tcaagaggca tgctagaacg ttaggtcagc     2460

ctactgacag ctgacaaaca attaatgcga aatcatgtca caccaaccca tagccgtgtc     2520

cacgcagcaa ctccaccacc ttaggatttc cccctccaaa ttattcagac caatggcttg     2580

ccaaatggcc tctcccaaaa ttctgtacag ttttgctcag gtcacgccaa cagggaaacc     2640

tcaagtgtag gtctaattag tgtttctggg atccaaagtt agaggaaaat ttagatttta     2700

ttgcctggat ctgctttaaa gacaattggt gtttacaccc tcttgtcagc aaaacagcta     2760

gttaggtaag gacatatagt tccaagtagg taaagtcact tgattacaaa tgttcttaac     2820

tatcgtctct gtaattcctt tatacaggac agtacaaaat tgtgggacat gctctggtaa     2880

cacacagata tgggttgcat atgatccaga attacagctg atattatgga tgacaactgc     2940

taaggtccat aaaatgaaga ctgtattgta ttgagggata gaaattgatc atttaatggg     3000

taacaactgc tgagctcaaa gatttgtgat tgttaaaact tctctggcat ttaatcatta     3060

ataaacatct gtattgtgac agc                                             3083


<210> 524
<211> 10075
<212> DNA
<213> Homo sapiens

<400> 524
tgtagcagcc ttagtcgccg ccgccgcggg gcgaggtcgc cgccatggcc cgctggatcc       60

cgaccaagag gcagaagtac ggggttgcga tctataacta caatgcttct caagatgtgg      120

agctctcctt gcagatcggt gacacagttc acatcctgga gatgtacgag ggttggtaca      180

gaggatatac cctccaaaat aaatctaaaa agggcatttt ccctgaaaca tatatccatt      240

tgaaagaggc aactgtggaa gacctggggc agcatgaaac cgtgattcct ggcgagctcc      300

ccctggtgca ggagctcacg tccactctgc gagaatgggc tgtcatctgg cgaaagctct      360

acgtgaacaa caagctcacc ctcttccgcc agctgcagca gatgacgtac agcctgatcg      420

agtggcggtc ccagatcctg tctgggacgc tccccaagga tgaactggca gagctcaaga      480

agaaagtcac agccaaaatt gatcatggga acagaatgct ggggttagat ctggtggtgc      540

gagatgacaa tgggaacatc ctagaccctg acgaaaccag caccattgcc ctcttcaagg      600

cccatgaggt ggcctccaaa aggattgagg aaaagatcca agaagagaag tcaatcctgc      660

agaacctcga tttgcggggc cagtccatct tcagtaccat ccacacctat ggcctctatg      720

tgaacttcaa gaactttgtc tgcaacatcg gggaagatgc agagttgttt atggccctct      780

acgacccaga ccagtccact tttatcagtg agaactatct aattcgttgg ggcagtaacg      840

ggatgcccaa ggaaatagag aagctcaata acctccaagc agtgtttaca gaccttagca      900

gcatggacct catccggccc cgcgtcagcc ttgtgtgcca gattgtccgc gtgggccata      960

tggagctgaa ggaaggcaag aagcacacct gtggactccg aagacctttt ggagtggcag     1020

tgatggatat tactgatatc atacatggga aggtggatga tgaagaaaag cagcatttta     1080

ttccctttca gcaaattgcg atggaaacct acatccgcca gaggcagctc atcatgtcgc     1140

ctttgataac atcacacgtg attggggaga atgagccact cacttcagtc ttgaataaag     1200

tgattgcagc aaaggaagtg aatcacaaag ggcaaggcct ttgggtatcc ttgaagctct     1260

tgcccggtga cctcacccag gttcagaaga atttttcaca cttggttgat agatcaacag     1320

caatagcccg gaagatgggc tttcctgaaa tcatactgcc aggagatgtt cggaatgaca     1380

tttatgtcac cctgatccac ggtgagtttg acaaagggaa gaagaagacg ccaaagaatg     1440

tggaggtgac gatgtctgtg cacgatgagg agggcaagct cttggagaaa gcaattcacc     1500

ctggtgctgg atatgaaggc atttcagaat acaaatcagt agtctattac caagtcaagc     1560

agccctgttg gtatgagact gtcaaggtat ccattgctat agaagaagtc acacgctgtc     1620

atataagatt taccttccga cacaggtcat ctcaggaaac cagagataaa tcggagcgag     1680

catttggggt ggccttcgtg aagctgatga acccggatgg caccactctg caggatggga     1740

ggcacgatct ggtggtttat aagggtgaca acaaaaaaat ggaagatgct aaattctacc     1800

tgaccctgcc tggaaccaag atggagatgg aagaaaaaga gcttcaagca tccaaaaacc     1860

tggtcacctt caccccaagc aaggatagca ctaaagacag ctttcagatt gccaccctca     1920

tctgctccac aaagctcacc cagaatgttg acctgttagg cttgttaaat tggcgttcca     1980

actcccagaa cattaaacac aacctaaaga agttaatgga agtggatgga ggagagattg     2040

ttaagttttt gcaagataca ctagatgcac tctttaacat aatgatggaa atgtcagaca     2100

gtgaaaccta tgacttcctt gtgtttgacg cactggtatt tattatttca ctgataggag     2160

acatcaagtt ccagcatttt aatcctgtac ttgaaaccta catttacaag cacttcagcg     2220

ccactttggc atatgtgaaa ctctccaagg tactgaactt ctatgtggct aatgcagatg     2280

actccagcaa gactgaactg ctttttgctg cgttgaaagc cttgaagtac ttgtttagat     2340

tcatcatcca atcccgagtg ctctacttga gattttatgg gcagagcaaa gatggagatg     2400

agtttaataa ttcaattcgc cagttatttc ttgctttcaa tatgctgatg gacaggcctc     2460

tggaggaagc cgtcaagatc aagggggcag ctttgaagta ccttcctagc ataattaatg     2520

atgtcaaact tgtatttgat cctgttgagc tcagcgtgct cttctgcaaa ttcattcaaa     2580

gcattcctga caaccagctg gttcggcaga aacttaactg catgaccaag atagtagaga     2640

gcactctttt tcgacagtca gagtgcagag aagtgctgct gccactgctg acagaccagc     2700

tcagcggcca gttagatgac aactccaaca agcctgacca cgaggcaagc tcgcagcttc     2760

tgagcaacat cctggaggtg ctggacagga aggatgtggg tgccactgcg gtgcacattc     2820

agcttataat ggaacggctg ctgagaagga tcaaccggac agtgattggg atgaaccggc     2880

agtctcccca catcgggagt tttgtggctt gcatgattgc cctgctgcag caaatggacg     2940

acagccacta tagccactac atcagcactt tcaaaaccag acaagacatc atcgacttcc     3000

tcatggaaac ttttatcatg ttcaaggacc tgattggaaa gaatgtctat gccaaagatt     3060

ggatggtgat gaatatgact caaaacaggg tttttctccg tgctataaat cagtttgctg     3120

aagttctcac aagattcttc atggatcagg caagctttga acttcagctc tggaacaatt     3180

acttccattt ggcagttgca tttctcaccc atgagtccct tcagcttgaa accttctcac     3240

aagccaagcg caacaaaatt gttaaaaaat atggggacat gagaaaggaa atcggcttta     3300

gaatccggga catgtggtat aacctgggtc cccacaaaat caaattcatc ccatccatgg     3360

tgggtcccat tctggaggtc actctgaccc ctgaagtaga gctccggaaa gccacaatcc     3420

ccattttctt tgatatgatg cagtgtgagt tcaatttcag tggaaatggc aatttccata     3480

tgtttgagaa tgagctgatc acaaagctgg accaggaggt agaagggggc agaggagacg     3540

aacaatacaa ggttcttctg gaaaaactgc tcctagaaca ttgccggaaa cacaaatacc     3600

tctccagctc tggggaggtc ttcgccctcc tggtcagcag cctcttagag aacctgctgg     3660

actatagaac catcatcatg caagatgaga gcaaggagaa ccgtatgagc tgcactgtga     3720

acgtgctgaa cttttataaa gaaaagaaga gagaggacat atacataaga tatctgtaca     3780

agcttcgaga tttgcaccga gactgtgaga actacacaga agctgcctac acgcttctct     3840

tgcacgctga gcttctgcag tggtctgaca agccctgtgt gcctcatttg cttcagaagg     3900

acagttacta tgtttatacc cagcaagagc ttaaagagaa gctgtatcaa gaaatcatat     3960

catatttcga caaaggcaaa atgtgggaga aggccatcaa gctgagcaaa gagttggctg     4020

agacttacga aagcaaagta tttgactacg agggccttgg caacctcctg aaaaaaaggg     4080

cctcatttta tgagaacatc attaaggcaa tgaggcctca gcctgaatac tttgctgttg     4140

gatactatgg acagggcttt ccttctttcc tacggaataa aatcttcatc tatcggggaa     4200

aggagtatga gaggcgagag gacttcagcc tgaggttgtt aacccagttc cccaatgcgg     4260

agaagatgac cagtaccacg cctcctgggg aagacatcaa gtcgtccccc aagcagtaca     4320

tgcagtgctt cactgtaaag ccagtgatga gcttgccgcc cagctacaag gataaacctg     4380

ttccagagca gatcttaaac tactacagag ccaatgaagt gcagcagttc agatactccc     4440

ggccgttccg gaaaggagaa aaggatccag acaatgaatt tgctacgatg tggattgaac     4500

ggaccacgta tacgactgca tatacctttc ctgggattct caagtggttt gaagtcaaac     4560

agatttcaac agaagagatc agtcctctgg agaatgccat cgaaaccatg gagctgacca     4620

acgagaggat cagcaactgt gttcagcagc atgcctggga ccggtccctc tctgtgcacc     4680

ctctctccat gctgctcagt ggcatcgtgg acccggccgt catggggggc ttctccaact     4740

atgaaaaggc tttttttaca gaaaagtact tgcaggagca tcctgaagac caggagaagg     4800

ttgagctgct aaagcgacta atagcattac agatgcccct gctaacagaa gggatccgca     4860

tccatgggga gaaactcaca gagcagctga agccgctgca tgagcggttg tcttcttgct     4920

tccgggaact caaggagaaa gtagaaaagc actatggggt tataacactg ccacccaact     4980

tgacggagag gaagcaaagc cgcacggggt ctattgtgct cccctacatc atgtcttcca     5040

ctctgcggag gttgtccatc acctcagtca cttcctctgt ggtttccacc tcttcaaact     5100

cgtctgacaa tgctccttcc agaccgggat ctgatggctc aatcttggag ccacttttgg     5160

agcgcagggc ctcgtcaggt gccagagttg aagatctgtc ccttagagag gagaacagcg     5220

agaaccggat cagcaagttt aagagaaaag actggagtct gagcaagtcc caggtcattg     5280

cagagaaagc accagaaccc gatttgatga gcccaaccag aaaagcacaa aggccaaaga     5340

gtctccagtt gatggataat cggctatcac catttcacgg ttcttcacct cctcagtcaa     5400

cacccttgag cccacctcca ctcactccca aagccaccag gaccctaagc tccccatcgt     5460

tgcagacaga tggaatcgcg gccactcctg tcccacctcc acctcccccc aaaagcaagc     5520

cctatgaagg cagccagagg aactccactg agctcgctcc cccactgcct gtccgaagag     5580

aagccaaagc accaccccct ccacctccaa aggctcggaa gtctggcatc cctacttccg     5640

agcctggatc ccagtaagga tcttgccctc cctgcaacac cgagtgcctt agacagctgc     5700

tgcctgagaa ctggcctcca gccggtgtcc tcattccatg gggctccctg ctgactgcat     5760

ttcctgatct gggatgatgt ttaccagccc aaaaccagtc atgttcttcc aaaagcttct     5820

ctttgataga attttgaggc catgccacct cccttccagt ccacatggaa ttccagaatc     5880

agtcacagcc tctgattttt tccaagaaga gattgccttc accattgtta aatgtcagcc     5940

tgtacggcag agacatggtg gtctgcacaa gcctggacaa gttcttccat attgatggtg     6000

gagcaacccc tgtaatctac tccttggaag gattttttgc tttgcttatg aaaagctgtg     6060

cttgagactt aggtactttt ctcacgtgga cacactgatc ccatcccata ttgcatcttg     6120

gaagagatgg atatcaagta cactttggta gctgaaataa tcatatcttt ctgatgtcta     6180

ttgtatctcc tttgaggaaa agaacacaca tttttaatgg agattggctg ctttcaggta     6240

tgtgtgtcta tcattgaaag agcatggact caaacatcag ccctgagttc ttgagtccac     6300

ccaactccca tcttcttgtg gcacaggaaa gctgccctct ccctctccca ccacactcct     6360

gactaatggc cttcactgcg tcgcagtcac tccttcccta cggacttctt tgaagctctt     6420

ccttttgcac atacggcttt tttttttttt tttttttttt gtcctattac ctcctctgag     6480

cgcaaatcac tggctacaag ggacttacca gtctggattc agcagtttct tttctaaaac     6540

ccatttgggt gactcagcag ccgcatctgc tacctgattt tatcctggag aatacagtgc     6600

aatatttctc tttgattatt tattcctctt gattgtggaa ttaatttgat tgcttgctaa     6660

tggtactagt agtactcctt tcagaagaaa aaatggagcg atttaggtga ccaaatatta     6720

catacataaa tagccacatg aagttttaga cgtttggact tgaagcctca aagatcaacc     6780

aaccagtccc cttatttagt aaataaggaa attgaggcta cacacagaaa attgtgctac     6840

agattattac taataaccca gcttgctaaa ttaggctata cctaggtaat ctctagaaga     6900

caactctgac agactcttta atatttaccc ctggttggaa caatatttga aatgtcccag     6960

atatttctat gctacttaga tatttgtggc aaagcagaaa gctttttgac tgtgaaggca     7020

gaggtcagca ctgggggaaa cttgctggtg gtctctccca caaccttgcc cagagtcctt     7080

tccactaagg aggtgaagag aacagagaaa gagatttcca tttctgctgc cagagctggt     7140

atttgcctgc ctgattctct gtgtttcctg tttcaccgcc accctttcag gagagaacta     7200

caccagttca tcatgagggt cagggaagca aaagctctca gatgtgtcca gggcgttact     7260

taagaaatga gtatgcagat tctggaaggg gtgtggaaaa ggtgatcctt tacccccacc     7320

caggaaaacc tgcattgtgc tagcatggaa gaatcatggg ctttggaatt aaacccattt     7380

ggtggaatta aacccatttg gtttcaaatc ccagttatga catctgttaa ctttgcaaac     7440

tcacaaaaat tatttgaaat tatctgagtt ttcattttct caccttccag aatggggata     7500

atgcctcctg catcggttgt tgtgaggttt caatgagatg aaatatggga aagaagaggt     7560

actcacctga tggtccctgc tttcctctgc taggcctgag taggaactgg aactctctaa     7620

gagcattact catacttttt ttttcttcca aggtagtttg gaatgtgagt gcaagttagt     7680

tctgcacata cagcccttct ccaaatggtg gtttcctttg aggtctttta catgattatt     7740

tatgactaga gacaaactta ataagaactc aagaggattt taaatggaga gaactcaagc     7800

tgtagagaaa ggaggaggca acagacagga tatgtagggg cttacctaga gcctggcacg     7860

acttctgaga agtcacccag cagaccggct agaggggatt tgtgtgccac actctacttg     7920

ccgggctgcc attaaaatag aaagatataa aactgggtca ccaaaaaaac caaacctcaa     7980

ggctatcctt ccagagcagt agaaatgagt cccacagcct ggtctttgag cagaggctgg     8040

gaagatagga tacatcactg tctggatacc ttctcttttt aatagaatat attccgtatg     8100

attccctttc caccttaatg gaaataatag ctctctcctg cctgaacaaa agggattcca     8160

ggtagtattg tggctaagag attacagcgg acgatggaag gttcattttt tagggaaggt     8220

gttgggtagg aagagtcaca tttgacagaa ttcataaata atgtgtcctg aagtcagagg     8280

atgactgcaa agaaacacct catgattcca ttaaatataa agagataagg agcaaggagg     8340

aaaaaagaga aagaattggt ctttattttt cttgctaaga actctctgga gtattgaaag     8400

acattgaaat tatccctaaa attgtcacaa cttttgtgaa tactggtata cggttggagg     8460

tgtttttaaa tctttatttc ctctctttct ttgttctagt gacttgtctt gctttaagat     8520

tttttttaaa ggattgtttt attcaacata tatcaagttc ttatggaatg ccagtcatgg     8580

tactagcccc ttgggatgta gtggttgagt gtgttcaatg gaaacagccc cagtatacaa     8640

agacagttca ctctggtgtg ctgtaggatt ggaaagggag tggtaccaga tgaaaatgaa     8700

accctaaaga agactgctgg gccatgagtt gcttcctcct cctccacctt aaccctctga     8760

ttccagaatt gcagtcattt tcttctgcca aggaaatcca ttaaaaactg cagccacact     8820

gcaatttcct aatgtagaac aagatataaa gcaggctttg agacaacaac ctacctttgt     8880

ttactctttc caagctggaa gagtccttct cctctagttg cccctaggtc actggctaat     8940

ttattttaaa atttagatgg aactcatgta tagttaagtg cacaaatctt agccgtgcag     9000

atgggtaatt ttcacatagc tatttgccca catccgtgcc tctaagatag agacatacac     9060

tgttttcagc accccagaaa gttcccacat gcccatggtg ccattttgtg aaaggtattt     9120

ataaggccct tcaaatttgt ggcttccttt ctcatacttc tcaggtataa tgaaaggggg     9180

agaaaaaccc caccatcaac acaaaacaag gctataaaga ctgtgcacct tttaacaagt     9240

caatttgtag tcagtccctg ggcctgtctt tttttttttt taattttgaa gctacctgag     9300

gtttagaatt ccttcagccc tagctgcttt tattctgctt tttatttaaa caaaaagagg     9360

gggaggatct gaaggaaact agttttctgt acaaaggctt tgaggtccat ggactatact     9420

tgtcccattt atcatcccag gtggtgcttt gaccctgcca taccctggct attaagataa     9480

aaagatttgt ggacattaaa attatgaata tgtcagtaat aatccagcac acattgaaat     9540

attgacacag attaccataa tttgtgcaac atcttataaa caatgtcatt tccatagtag     9600

tctaaggctt caccagcctg gcccactgta tctagacttt aggttcattt taataattat     9660

gctttccttc tctgtatcat ttgggaagtt gataaatatc acttccttag ataccttcat     9720

tcagtgatat atctggcttt tacaattaaa ttggaaaagg taagtttctc tttggtgggt     9780

tgagagttgg accatcaatt ctaatctaca aaaggaaatt catgatttca ctctgacgcc     9840

taggatctag ccaaggctgg tctgcagtat cagatgtcca aactcatcta ctattagcca     9900

tattttgtga gtcgtttgtc taaactttgt caaaaatgcc tttgccatga ttttgttgct     9960

atctggattt caaacatgga cagttaggaa gatgtgcatt gaagtaggaa aattttgttc    10020

agatttgctg ttatttattt tttaaattaa aaatggaaat gtattttaaa gttta         10075


<210> 525
<211> 1960
<212> DNA
<213> Homo sapiens

<400> 525
tcctgtcact ggcttatatg gacacgtcag cccaccgtca cgtgaccgca ggctgctaaa       60

aacagctcca gcacccactc caaaccaggg cctgaaacaa tgtcctccac cgagagaaac      120

gtaaaggaca cttgatcaca caatccctgg aataatatcc aggaaacact tgctggagcc      180

actcgcagca cccttccctg gcagcacact tggggacagc gaggagatga gcgcatctct      240

gaattacaaa tctttttcca aagagcagca gaccatggat aacttagaga agcaactcat      300

ctgtcccatc tgcttagaga tgttcacgaa acctgtggtg attctccctt gtcagcacaa      360

cctgtgtagg aaatgtgcca gtgatatttt ccaggcctct aacccgtatt tgcccacaag      420

aggaggtacc accatggcat cagggggccg attccgctgc ccatcctgta gacatgaagt      480

ggttttggat agacatgggg tatatggact tcagaggaac ctgctggtgg aaaatatcat      540

tgacatctac aagcaggagt ccaccaggcc agaaaagaaa tccgaccagc ccatgtgcga      600

ggaacatgaa gaggagcgca tcaacatcta ctgtctgaac tgcgaagtac ccacctgctc      660

tctgtgcaag gtgtttggtg cacacaaaga ctgccaggtg gctcccctca ctcatgtgtt      720

ccagagacag aagtctgagc tcagtgatgg catcgccatc ctcgtgggca gcaacgatcg      780

agtccaggga gtgatcagcc agctggaaga cacctgcaaa actatcgagg aatgttgcag      840

aaaacagaaa caagagcttt gtgagaagtt tgattacctg tatggcattt tggaggagag      900

gaagaatgaa atgacccaag tcattacccg aacccaagag gagaaactgg aacatgtccg      960

tgctctgatc aaaaagtatt ctgatcattt ggagaacgtc tcaaagttgg ttgagtcagg     1020

aattcagttt atggatgagc cagaaatggc agtgtttctg cagaatgcca aaaccctgct     1080

aaaaaaaatc tcggaagcat caaaggcatt tcagatggag aaaatagaac atggctatga     1140

gaacatgaac cacttcacag tcaacctcaa tagagaagaa aagataatac gtgaaattga     1200

cttttacaga gaagatgaag atgaagaaga agaagaaggc ggagaaggag aaaaagaagg     1260

agaaggagaa gtgggaggag aagcagtaga agtggaagag gtagaaaatg ttcaaacaga     1320

gtttccagga gaagatgaaa acccagaaaa agcttcagag ctctctcagg tggagctgca     1380

ggctgcccct ggggcacttc cagtttcctc tccagagcca cctccagccc tgccacctgc     1440

tgcggatgcc cctgtgacac agggggaggt tgtacccact ggctctgagc agaccacaga     1500

gtctgaaact ccagtccctg cagcagcaga aactgcggat cccttgtttt accctagttg     1560

gtataaaggc caaacccgga aagccaccac caacccacct tgcaccccag ggagcgaagg     1620

tctggggcaa atagggcctc caggttctga ggattcgaat gtacggaagg cagaagtggc     1680

agcagccgca gcgagtgaga gggcagctgt gagtggtaag gaaactagtg cacctgcagc     1740

tacttctcag gagttagtaa tctgcctagc gcttttggct tttcttattc ttcactacat     1800

ctggagtcag attcagtgct tgatttttac tttaatggat tggatttgag gctcctcccc     1860

tccagggaca ggctgcagct ccagcgagtg gcagtggagc tgattctgag ccagctcgcc     1920

atatcttctc cttttcctgg ttgaactccc taaatgaatg                           1960


<210> 526
<211> 4697
<212> DNA
<213> Homo sapiens

<400> 526
cacgggtgcc gtggagtcca tcgtcatcct gcccagccag tctgcggcgg tgggctgggc       60

cgggtgattg gtgtggtgag gcgtcttcca tatcagcact gttgcttctc ccctcttgca      120

gtgcggcacc ttcccgtctg atgctggcgt tgtgcgtatg gtgccctgac gtctgtccac      180

gtgggcgcgg aagcaaacag cgatgtccca gacgcaggac tacgagtgca ggagccataa      240

tgtcgacctg ccggagtcga ggattccagg gtcgaacact cggttggagt gggtggagat      300

catcgaaccg cgcacccgcg agcgcatgta cgccaacctg gtcaccggtg agtgcgtgtg      360

ggacccgccg gccggcgtcc gcatcaagcg caccagcgag aaccagtggt gggagctgtt      420

cgaccccaac acgtcccgct tctactacta caatgccagc acgcagcgca cggtgtggca      480

ccggccgcag ggctgcgaca tcatcccgct ggccaagctg cagacgctga agcagaacac      540

ggagtccccg cgcgcctcgg cggagagcag ccccgggcgc ggcagcagcg tcagccgtga      600

gggcagcacc agctcctccc tggagcccga gcccgacact gagaaagcgc aggagttgcc      660

agcgagggcc gggcggcccg cggcgtttgg gacagtgaag gaggacagcg gcagctcttc      720

accaccagga gtgttccttg agaaggacta tgagatttac cgggattaca gtgcggacgg      780

ccagcttctt cactacagga cctcctcgct gcggtggaac tcgggcgcca aagagcgcat      840

gctcatcaag gtcgctgatc gggagcccag cttcctcgcc gcccagggca atggctacgc      900

cccagacggc ccacctgggg tccgctcccg cagaccctcc ggcagccagc actcacccag      960

cctgcagacc ttcgccccgg aggctgacgg caccatcttc ttcccagaga ggaggccgtc     1020

acccttcctg aagagggccg agctcccagg gagcagctcc ccgctgctgg cccagccccg     1080

aaagccctcc ggggactcgc agccctcctc cccgcgctat ggctatgaac ccccgctcta     1140

cgaggagccc ccagtggagt accaggcccc catctacgat gagcccccca tggacgtgca     1200

attcgaggct ggcgggggct accaggccgg ctctccccag cggtcgccgg gccgtaagcc     1260

ccggccgttc ctccagccca acaagcaggg ccccccctcg ccctgccagc agctggtgct     1320

caccaagcag aagtgtcccg agcgcttcct gagcctggag tacagtcccg ccggcaagga     1380

gtacgtgcgg cagctggtct acgtggagca ggcgggctcc agccccaagc tgcgcgccgg     1440

cccgcggcac aagtacgcgc ccaaccccgg cggtggttcg tactccttgc agcccagccc     1500

ctgcctgctg agggaccagc gcctgggcgt caagtccgga gactacagca ccatggaggg     1560

acctgagctg cggcacagcc agccgcccac gccgctgcca caggcccagg aggatgccat     1620

gtcctggtcc agccagcagg acaccctgtc ctccacaggc tactccccgg gcacgcgcaa     1680

gcggaagagc agaaagccct ctttgtgcca agccaccagc gccaccccca ctgagggccc     1740

cggggacctg cttgtggagc agcccctggc cgaggaacag cccccgtgcg ggaccagcct     1800

cgcccccgtg aagcgagcgg aaggtgaggc cgaaggggcg cggggcgcgg ccgagccctt     1860

cctggcgcag gctcggctgg cctgggaggc gcagcaggcc cacttccaca tgaagcagag     1920

gagcagctgg gactcccagc aggacggctc tggctacgag agcgacggcg ccctgccact     1980

gcccatgccc gggccggtgg tgcgggcctt cagcgaggac gaggcgctgg cccagcagga     2040

gaacaggcac tggaggaggg gcaccttcga gaagctaggc ttcccccaga tcctgctgga     2100

gaagagcgtc tccgtgcaga ccaacctggc ctcaccagag ccctacctcc acccctcaca     2160

gtctgaggac ctcgctgcct gtgcccagtt cgagagcagc cggcagagcc gcagcggcgt     2220

tcccagctcc agctgcgtct tccccacttt cacgctgcgc aagccctcct cggagacgga     2280

catcgagaac tgggcctcca agcacttcaa caagcacacg cagggcctct tccggcggaa     2340

ggtgtccatc gccaacatgc tggcctggag cagcgagtcc atcaagaagc ccatgatcgt     2400

gacaagcgac cggcacgtga agaaggaggc ctgcgagctc ttcaagctga tccagatgta     2460

catgggtgac cggcgggcca aggccgaccc actgcacgtg gccctggagg tggccaccaa     2520

gggctggagc gtgcagggcc tgcgggacga gctctacatc cagctgtgcc ggcagaccac     2580

cgagaacttc cgcctggaga gcctggcccg cggctgggag ctcatggcca tctgcctggc     2640

ctttttcccg cccaccccca agttccactc ctacctggaa ggctacatct accggcacat     2700

ggaccccgtc aatgacacta aaggggtggc gataagcacg tatgccaagt actgttacca     2760

caagctacag aaggcagccc tgaccggggc caagaagggg ctgaagaagc ccaacgtgga     2820

ggagatccgg catgccaaga acgccgtgtt cagcccgtcc atgttcggca gcgcactgca     2880

ggaggtcatg ggcatgcaga gagagcgcta ccccgagcgc cagctgccct gggtgcagac     2940

acggctctct gaggaggtgc tggcgctcaa cggtgaccag acagagggca tcttcagggt     3000

ccctggggac attgacgagg tgaatgccct gaagctgcag gtggaccagt ggaaggtgcc     3060

cacaggcctg gaagaccccc acgtccctgc gtccctgctg aagctgtggt accgggagct     3120

ggaggagccc ctgatcccgc acgagttcta cgagcagtgc atcgcgcact acgacagccc     3180

cgaggcggcg gtggccgtgg tgcacgcgct gccccgcatc aaccgcatgg tgctgtgcta     3240

cctcatccgc ttcctgcagg tcttcgtgca gccggccaac gtcgcggtca ccaagatgga     3300

tgtcagcaac ctggccatgg tgatggcgcc caactgcttg cgctgccagt ccgacgaccc     3360

gcgcgtcatc ttcgagaaca cccgcaagga gatgtccttc ctgcgggtgc tcatccagca     3420

cctggacacc agcttcatgg agggtgtgct gtagcggggg cgcccgggga caggagggat     3480

gtcctgccgc ccccagccag gccgaactcc gcactcgctc tcccggcaga ggggccagaa     3540

tcgcccggcc cagccctgga gccccctcca ctcccccagg cccctggccc cggcgctccc     3600

cacgtcttct gcctggtctg agggtgcagc cagggcacag cagcggcggg gagggcgcct     3660

ctggcccccc acctcacggc cagttcccgc gggcaccgcc tcgccctccg ctggccgcgg     3720

gtcagctccg agaaagtgcc ttctgtgtcc tggagccgag cgacgctgcc tccttggggc     3780

cgggctgcct ccctgtggct cctgcgcgcc ctggcctggg ccttgcccag ccgccccggt     3840

ctctccttcc ctttctcctg tcctcgtcct ggcctgcagc tcttcccagc cccgagagag     3900

cttcccgacc tgtccccgcc tcctctccct ccctcggccc gtggtcccca gctggtgact     3960

gctcaggagt ttgggggctc caggacagtg ggcccggggc ctggcaggct ctcggtgggt     4020

ggggtggggg cccccaaacc aaagtcctct ggggtaggga gcagggctgg gcaggcattc     4080

tgggggcagg gtgggggagg ggcgagagta tttttttctt cgtgtaactg taaatccaga     4140

atctatcctg catcgcagcc caccgtgtat agagatataa atagagggaa agatataaga     4200

actaaatttg ctaatgacat agttttaacc taaatgctat ttatctctga gccgtccccg     4260

tcctccgtgc agagcaagtt gaggtcattc cttcttttct tctccgatct tttttcttgg     4320

cttctgacca aaaaccaagc tctaccccat ccccatccca gacctgcagg agacgagcga     4380

gcgggaaggc gccgggcccg ggactgtccg ttctcggggc cagagctgct gggggaccga     4440

gtttgtacat tttccatttt ggaattttga gttccaattg ttgtaaaact taatttctcc     4500

ccagttttta tatatatatt ttttagagtt ccgtttttat ttattaaaaa caaaagcccc     4560

agccctgccg aggcctgggc ggcgtcctca gtcgggtggt cccggggcct ttgcggtccc     4620

gcccggctga gacgctcgcc ccgacgcatg gacccgagag gcgacgacac gagtgaataa     4680

agtgcacatg gaccctg                                                    4697


<210> 527
<211> 1614
<212> DNA
<213> Homo sapiens

<400> 527
gcgcagaggg gcacggccct cactgccccg gccggggcga gagcggctcc gcccctcgag       60

cgccgggtag gccggggccg gcggggcccg gaaggcgacg ggaaggagcc gagcttgggt      120

tatggcggcg ccgggcgcgc tgctggtgat gggcactctc actctgtcgc ccaggctgga      180

gtacagtggc gtgatctcgg ctcactgcaa cctctgcctc ctgagttcaa gcgattgtca      240

tgcctcagcc tccggagtaa ctggggttac aggcgtgcac caccacaccc agctaagttt      300

tgtattttta gttgagacgg ggttttgcca tgttggccga gctagtcccg aactcctggc      360

ctcaagtgat ccgcctgcct cagcctccca aagtgctggg attataggcg tgagccaagg      420

gctcaaccta acttggtctt aagtgtgatt tctgctatgc acacttctgg cttcaccagc      480

catggagttt ggccgggatg gtctactcat ccgtaggctg catgtctccc tgcgcagcct      540

tcaatagaat gaactaatgg gaaaggtttc actgctctcg caacctttgg ttacatccag      600

gagcagatct cagtttggta caactgtgtc taacacctct ctgatagctt tttagtgaaa      660

gaaagaggac ctttgttagg caacagtatc cagctagaat ttaatcacat tgttctgttt      720

tcattatata cagcttttca ggtaccttct attcaagatc caccgtgggc gccctgctgg      780

catctgagct gggatggaaa ttctatgatg ctgatgatta tcacccggag gaaaatcgaa      840

ggaagatggg aaaaggcata ccgctcaatg accaggaccg gattccatgg ctctgtaact      900

tgcatgacat tttactaaga gatgtagcct cgggacagcg tgtggttcta gcctgttcag      960

ccctgaagaa aacgtacaga gacatattaa cacaaggaaa agatggtgta gctctgaagt     1020

gtgaggagtc gggaaaggaa gcaaagcagg ctgagatgca gctcctggtg gtccatctga     1080

gcgggtcgtt tgaggtcatc tctggacgct tactcaaaag agagggacat tttatgcccc     1140

ctgaattatt gcagtcccag tttgagactc tggagccccc agcagctcca gaaaacttta     1200

tccaaataag tgtggacaaa aatgtttcag agataattgc tacaattatg gaaaccctaa     1260

aaatgaaatg acaatgattt tgtatcagtg gtccaaacag aactaagcat aaatcattgt     1320

gccatcccaa acctcgttcc agccgccttg cccatactag attctaaatg tttctaaagg     1380

caaaccccaa tgtgtcaaga cagacttgtt taggtgtaat tttaggaatt atgctggttc     1440

atcaggaagc agagggggag ttttaaaagt caagcttaaa ttgaagttta aattcatcta     1500

taaccaaatc aaatgatcag aggaaattct gtaatcaatg ctggaaatcg ttacattgtt     1560

tagaacattc ttgctcatgc ctgtatttgc acaaataaat gaaacttcgc tgtc           1614


<210> 528
<211> 1966
<212> DNA
<213> Homo sapiens

<400> 528
agtaaccccg agtctgcgga agtggtgacc cgtgggacgc ggctgagaca ggagactgaa       60

aggaaccata atttgtgaca tcagttgttt tctttgataa gcagctattt atgattctgg      120

aagattaagg cagataggaa accccatctg agattttaat aaatccctca aacaataaac      180

cacatcatgg acatacagct ggaccctgcc agagatgacc tgcctctcat ggccaacacc      240

agccacatac ttgtgaagca ctatgtactg gatttggatg tggattttga aagtcaagtc      300

attgagggga ccatagtgct tttcctcgag gatggaaaca gattcaagaa acagaatagc      360

tctattgagg aagcctgcca atcagaatca aacaaagcct gcaaatttgg gatgcctgaa      420

ccctgccata ttcccgtgac aaatgcaagg accttctcat ctgaaatgga atataatgat      480

tttgcaatct gtagtaaagg tgaaaaagat acttctgata aagatggtaa ccatgacaac      540

caggaacatg cttctgggat ttctagctca aagtactgct gtgacacagg gaatcatggg      600

agtgaggatt ttttgctagt gttggactgc tgtgatttat ctgtgttaaa agtcgaggag      660

gtggatgttg ctgctgtgcc aggtctggaa aaatttacaa ggtctcctga gctcacggtt      720

gtttctgagg agttcaggaa tcagattgta cgtgaacttg tgactttgcc tgcaaatcgt      780

tggagggagc agttagacta ttacgctcgc tgcagccagg ctcctggctg tggggaactc      840

ctctttgaca ctgacacttg gagcttgcag ataaggaaga caggggctca gacagctact      900

gactttcctc atgctatcag gatatggtac aaaactaaac ctgaagggcg atcggttaca      960

tggacctcag accagagtgg caggccatgt gtttatactg tgggatctcc cataaacaac     1020

agggcccttt ttccatgcca ggagccaccc gttgccatgt caacatggca ggctacagtt     1080

cgagcagctg catcttttgt tgttttaatg agtggggaaa attctgccaa accaacgcag     1140

ctttgggaag agtgctcaag ctggtattac tatgtaacta tgccaatgcc agcctccacc     1200

ttcacaattg cagtgggatg ctggacagaa atgaagatgg agacatggtc atcaaatgat     1260

ttggcaacag agagaccctt ctcaccttct gaggccaact tcaggcatgt tggtgtttgc     1320

agtcacatgg aatacccctg ccgcttccag aatgcttctg ccaccaccca ggagatcatt     1380

cctcatcggg tctttgcccc tgtgtgcctc acgggtgcct gccaagagac ccttctgcgg     1440

ctgatccctc cttgcctctc agcagcacat tctgttctgg gagcacaccc gttctctcgg     1500

ctggatgttc tcatcgtccc tgccaacttt ccaagtctgg ggatggccag cccacacatc     1560

atgttcctct ctcagagcat cttgacagga gggaaccatc tctgtgggac ccgcctctgc     1620

catgaaattg cccatgcctg gtttggccta gccatcgggg cccgagactg gacggaggag     1680

tggctgagtg aaggcttcgc cactcacttg gaggatgtgt tttgggccac agcacagcag     1740

ctggccccct atgaggcccg ggagcagcag gagctgaggg cttgtctgcg ctggcgtcgc     1800

ctccaggacg agatgcaatg ctcccccgag gagatgcagg tgttaaggtt tccacatgtt     1860

ggcggatgca gtggaagctt ctcttgagat ctttgccaca ctgttcaaca tgtttgacca     1920

ctctgtccta aaaacgcttt cttcttaaag cactttctcc tcctgg                    1966


<210> 529
<211> 2330
<212> DNA
<213> Homo sapiens

<400> 529
cttccggcgg gggcgcggct tggactgagg agcggacccg gccgggcgca ggggctggac       60

tggcggagca ggtggggtcc gcggccgccg gagcgttccg gtcggcgtct gggcatctcg      120

gcctcggcag aaagcgcgac ggccctgctg cgcggggccc gcggcgatgc cgttcctgca      180

cggcttccgg aggatcatct tcgagtacca gccgctggtg gatgcgattc tgggctccct      240

ggggatccag gaccccgagc ggcaggagtc tctggaccgg cccagttatg tcgccagcga      300

ggagagccga atccttgttc tcactgagct gctggagagg aaagcccact ctccctttta      360

ccaggaaggc gtgagcaacg ccctgctcaa gatggctgag ctggggctga cgcgggcggc      420

cgacgttctc ttgcggcatg gggccaatct caactttgaa gacccagtca cctactacac      480

ggccttgcac atcgccgtcc tgcggaacca gccggacatg gtggagctgc tggtgcatca      540

cggggccgac gttaatcgga gggaccggat ccacgagagt agccccttgg acctggccag      600

cgaggagcct gagcgcctgc cctgcctgca gcgcctcctg gaccttggag ctgatgtcaa      660

tgccgctgac aagcatggaa aaactgctct gctccatgct ctggccagca gcgacggggt      720

gcagatccac aatactgaga acattcgtct cttactggaa ggaggggcag acgtcaaggc      780

caccaccaaa gatggggaca cagtgttcac ctgcatcatc ttcctgcttg gtgagaccgt      840

gggaggggac aaagaggagg cccagatgat caaccgcttc tgcttccaag tcacacggct      900

gctgctggca cacggggccg accccagcga gtgcccagcc cacgagtccc tcacccacat      960

ctgcctgaag agctttaaac tgcacttccc tctcctgcgc ttcctcctgg agtccggagc     1020

cgcctacaac tgctccctgc acggtgcgtc ctgctggtct ggctttcaca tcatctttga     1080

gaggctctgt tcccacccag gctgcacgga agacgagagc catgcggacc tcctgcgcaa     1140

agctgagact gtcctggatc tcatggtgac caactctcag aaactccagc tgcccgaaaa     1200

cttcgatatc caccctgtgg gcagcctggc ggaaaagatc caggccctcc acttctcctt     1260

gaggcagctg gagagctatc ccccgcccct caagcacctg tgccgtgtgg ccatccggct     1320

ctaccttcag ccgtggcctg tggatgtgaa ggtcaaagcc ctgcctctgc ccgacaggct     1380

gaagtggtac ctccttagcg agcacagtgg ctccgtggaa gatgacatct gataggtctc     1440

aggctacagg aacgggggac acgggcagct caggtcagcc tgttggtaga tgctgggaca     1500

gcattagaag agggtctttt tgatctggga gatgagacgg gatccttcat gagaaaagcc     1560

agccaggtag agcctgaagc tgtgatcact ccagtggtga agggtgcagc tctggttctt     1620

ccagagagac tgcccccttc cctccagcgg cactccaagt cccccccatg ttggaaagag     1680

gaacagggct tggattgatg tttataccct ctgaattgga gggcagtgcc agggcatttg     1740

cagaagctgg gaaggaccaa gcctcagcac cccagggctg cggggctctt gttggccgca     1800

cgtggcagtg cagctggaga ggaagcctgg ggcacgtcct gtgcggtgcc accaaggccc     1860

cacccctgcc ccttttcctt ccaggttctg ttactcacag aagtgtttct ggtgggctct     1920

gcgggagaag acactaaggg ccccacaggc ttgtttcatg gtgttgcaag ccaagctggc     1980

ccctgcctgt tcctgtagct ctggggccag gtcagccgtg gccccaccta ccagaactgt     2040

gctctgctgg cagctgtgct tttgccaaac ccagggcctc agcgaccatg acttctgcta     2100

aaaagcaatc atgagtgcgt ggctggggac agacctctct gaagtgtctc ctgttgtgag     2160

gggctcactt tggagccact gaagagccga ctgtgccacc cacttgcgag cctcagtccc     2220

ttccaagctg cactggtcat tgggaattgt gtaaacacct ctggggataa gctgaggtga     2280

ctaaatgata tatttatatt ataagattaa actgactttc ttggccttaa                2330


<210> 530
<211> 2180
<212> DNA
<213> Homo sapiens

<400> 530
ccgggcgcag gggctggact ggcggagcag gtggggtccg cggccgccgg agcgttccgg       60

tcggcgtctg ggcatctcgg cctcggcaga aagcgcgacg gccctgctgc gcggggcccg      120

cggcgatgcc gttcctgcac ggcttccgga ggatcatctt cgagtaccag ccgctggtgg      180

atgcgattct gggctccctg gggatccagg accccgagcg gcaggagtct ctggaccggc      240

ccagttatgt cgccagcgag gagagccgaa tccttgttct cactgagctg ctggagagga      300

aagcccactc tcccttttac caggaaggcg tgagcaacgc cctgctcaag atggctgagc      360

tggggctgac gcgggcggcc gacgttctct tgcggcatgg ggccaatctc aactttgaag      420

acccagtcac ctactacacg gccttgcaca tcgccgtcct gcggaaccag ccggacatgg      480

tggagctgct ggtgcatcac ggggccgacg ttaatcggag ggaccgggaa aaactgctct      540

gctccatgct ctggccagca gcgacggggt gcagatccac aatactgaga acattcgtct      600

cttactggaa ggaggggcag acgtcaaggc caccaccaaa gatggggaca cagtgttcac      660

ctgcatcatc ttcctgcttg gtgagaccgt gggaggggac aaagaggagg cccagatgat      720

caaccgcttc tgcttccaag tcacacggct gctgctggca cacggggccg accccagcga      780

gtgcccagcc cacgagtccc tcacccacat ctgcctgaag agctttaaac tgcacttccc      840

tctcctgcgc ttcctcctgg agtccggagc cgcctacaac tgctccctgc acggtgcgtc      900

ctgctggtct ggctttcaca tcatctttga gaggctctgt tcccacccag gctgcacgga      960

agacgagagc catgcggacc tcctgcgcaa agctgagact gtcctggatc tcatggtgac     1020

caactctcag aaactccagc tgcccgaaaa cttcgatatc caccctgtgg gcagcctggc     1080

ggaaaagatc caggccctcc acttctcctt gaggcagctg gagagctatc ccccgcccct     1140

caagcacctg tgccgtgtgg ccatccggct ctaccttcag ccgtggcctg tggatgtgaa     1200

ggtcaaagcc ctgcctctgc ccgacaggct gaagtggtac ctccttagcg agcacagtgg     1260

ctccgtggaa gatgacatct gataggtctc aggctacagg aacgggggac acgggcagct     1320

caggtcagcc tgttggtaga tgctgggaca gcattagaag agggtctttt tgatctggga     1380

gatgagacgg gatccttcat gagaaaagcc agccaggtag agcctgaagc tgtgatcact     1440

ccagtggtga agggtgcagc tctggttctt ccagagagac tgcccccttc cctccagcgg     1500

cactccaagt cccccccatg ttggaaagag gaacagggct tggattgatg tttataccct     1560

ctgaattgga gggcagtgcc agggcatttg cagaagctgg gaaggaccaa gcctcagcac     1620

cccagggctg cggggctctt gttggccgca cgtggcagtg cagctggaga ggaagcctgg     1680

ggcacgtcct gtgcggtgcc accaaggccc cacccctgcc ccttttcctt ccaggttctg     1740

ttactcacag aagtgtttct ggtgggctct gcgggagaag acactaaggg ccccacaggc     1800

ttgtttcatg gtgttgcaag ccaagctggc ccctgcctgt tcctgtagct ctggggccag     1860

gtcagccgtg gccccaccta ccagaactgt gctctgctgg cagctgtgct tttgccaaac     1920

ccagggcctc agcgaccatg acttctgcta aaaagcaatc atgagtgcgt ggctggggac     1980

agacctctct gaagtgtctc ctgttgtgag gggctcactt tggagccact gaagagccga     2040

ctgtgccacc cacttgcgag cctcagtccc ttccaagctg cactggtcat tgggaattgt     2100

gtaaacacct ctggggataa gctgaggtga ctaaatgata tatttatatt ataagattaa     2160

actgactttc ttggccttaa                                                 2180


<210> 531
<211> 1359
<212> DNA
<213> Homo sapiens

<400> 531
gagttccaca tctgataccc aggagtctcc agcttccaag agaggtcggg tcacagccag       60

cagctatgtc tgacataaat cttgactggg ttgacaggcg tcagttgcag cgcttggagg      120

aaatgctgat tgttgtggat gagaatgata aggttattgg tgccgacacc aagaggaatt      180

gccatctgaa cgaaaacatt gagaaagggc tgctgcaccg agccttcagc gttgtcttgt      240

ttaacaccaa gaatcgaatc ctgatacagc agaggtcgga cacgaaagtc acgtttcctg      300

ggtattttac cgactcctgt agtagccacc cattatacaa cccagcagaa ctggaagaaa      360

aggatgccat cggagtgagg agggcagccc agaggcgtct gcaagcagag ctgggaattc      420

ctggggagca gatttctcca gaggacattg tgttcatgac aatctatcac cacaaggcaa      480

aatcagacag aatttgggga gagcatgaaa tttgttacct tctgcttgtg aggaaaaacg      540

tcactctgaa cccggatccc agtgaaacga aaagcatcct ctacctgtcc caggaggagc      600

tgtgggagct gctggagagg gaggcgaggg gtgaagtcaa agtcaccccc tggctaagaa      660

ccattgccga gaggtttctg taccggtggt ggcctcacct ggatgacgtg accccgtttg      720

tggagcttca caaaatacac agagtgtgag aggcagggag gtcgagtcag ccatgtgtaa      780

tgccctcagt gcaggcagac gcaccattga ggcaatgata caccctctcc aaaaaacagg      840

gcaaaagggg cacttgattg cccatcatgt ataaatcact atttcaacct tttcatcaac      900

tttgtcatat cttcattttc ccttttcctt atttccatat ttctcatctg cctggttgca      960

gggaggaaat ttaacatttc ctttgtccca atttccattt tataagcact tgtttgatta     1020

acagcagctg atcctgaaag tcttggggag atcttgagag tcctgaagca ggcggactag     1080

cctggctgga ccatgaggct gtctccccac agctttatcc aagcctccaa ggtcaggatg     1140

ggatctctgt atcatgtttt tctttttaaa tcacttattt cagagtgcaa cacaaggctg     1200

catttttaaa aaaaagacac attcaatctt gcatcctaat acaagcagta cggaagatgc     1260

gtatggtctc agccaagtga ctcgacgttt atccacttct gttcatttga tcgtttcagt     1320

aatatgctta caaataaaga catacttgct ttaaaacat                            1359


<210> 532
<211> 1850
<212> DNA
<213> Homo sapiens

<400> 532
cgcggcgcgg cgccggagga ggaagtggtg aggttgttgc tccttcagcg cctatcgctg       60

gctcttgggg cgcagagagg ggccgcagtc tccgcggctg cgtcgagctc ccttgcagtc      120

ccctccatgt tccccggcgc cactactccc cttcctaagg ccgccgctta ccccggggtc      180

tatggaagta atggaaggac ccctcaacct ggctcatcaa cagagcagac gagcagaccg      240

tttattagct gcaggcaaat acgaagaggc tatttcttgt cacaaaaagg ctgcagcata      300

tctttctgaa gccatgaagc tgacacagtc agagcaggct catctttcac tggaattgca      360

aagggatagc catatgaaac agctcctcct catccaagag agatggaaaa gggcccagcg      420

tgaagaaaga ttgaaagccc agcagaacac agacaaggat gcagctgccc atcttcagac      480

atctcacaaa ccctctgcag aggatgcaga gggccagagt cccctttctc agaagtacag      540

cccttccaca gagaaatgcc tgcctgagat tcaggggatc tttgacaggg atccagacac      600

actactttat ttacttcagc aaaagagtga gccagcagag ccatgtattg gaagcaaagc      660

cccaaaagat gataaaacaa ttatagagga gcaggcaacc aaaattgcag atttgaagag      720

gcatgtggaa ttccttgtgg ctgagaatga aagattaagg aaagaaaata aacaactaaa      780

ggctgaaaag gccagacttc taaaaggtcc aatagaaaag gagctggatg tagatgctga      840

ttttgtagaa acgtcagagt tatggagctt gccaccacat gcagaaactg ctacagcctc      900

ctcaacctgg cagaagttcg cagcaaatac tgggaaagcc aaggacattc caatccccaa      960

tcttcctccc ttggattttc catctccaga acttcctctt atggagctct ctgaggatat     1020

tctgaaagga tttatgaata attaaaatgg aaggccacag aaaaggggaa aagaggaaat     1080

aatacagtaa tcgttaatcc agcaaaaaga aatgaaaagg gaaaaccaca tagaagggta     1140

atcccggaaa tgcttcatct ggtggactgt gggagcagag gcattgccag gacttgggaa     1200

acagtcactg tgaaatgcgc tgcgtatctc attcactcac ttcagctaat gattccgact     1260

tggcagacgc taaactcatg gaggttcggt ttctcctgat acaaaccaaa tggctacctg     1320

gaagaatttc tttcaagcaa cagttatttt tcttatcttc agggttaaaa tgtataaaag     1380

ttatgtgtaa ttaatctata atgccataaa tgataatgca aaacctaaat aatatggtgg     1440

ccggaggggc tgccttatat ttgaaacatg ctttctatca tgcattgact gtatgcattt     1500

tgttaatgca cattctgttt gtttaaggtg tgtaagatac acacccttct agatgaaact     1560

atatgtgcca cactttgcac tactcataat gataacctca agactatcag aagaaatatt     1620

taaatttcca ttttatgaag aaaggaacca aattattatg ctttttaaaa caaattacca     1680

gtttacataa ttaatcaggg tgcattttaa gttctaactt cgtttattgt ataatgcatc     1740

atttgaaaat accaaggagg aaataccctt tgtttttaat gatgcaagag tggacgtaat     1800

gctagttggc agtattttat tgtaagaaat caataaagta attgtgtttt                1850


<210> 533
<211> 4362
<212> DNA
<213> Homo sapiens

<400> 533
gtggttagta gcgataaatg ctctgaagga aaaaacatac agtactgtga gaatgtagta       60

ttttgaaatg tttcatttgc aaaattgtac ttgatactca gaatagtgtt tttttttcct      120

aaaatactta atatgctgaa caggtcaatg tatcatctgc ctagtatgca taaacaataa      180

cagtaaatgt ttagtaattt gagcacagtt gggtatgttc atgtattttt tattccttac      240

tctgtttgca ttgccagtgt ttgattttgc tatttcaaag aaatggcatt ttgttgagtt      300

tgaaaatttg aaggtgcatt ggatcctgct aatttgttgg attctgctaa attgtagcag      360

tacagctctc aggttttgta gttaagagca taacttcact aaataaaaat atttttaata      420

caataatatg gaatcagagt aactctcctt tttcctgctc aaactttgat ttgctgaagc      480

tgcttcccga aaatcatgtg tgtcgactct ctggtcagaa tttgctccgg actctcttat      540

ggcagaatca gaaatattaa aagtttgtca gatatccaga ttgtacaggt tgcttgtggt      600

tactatcatt cacttgcact ttctaaagca agtgaagtct tctgttgggg acagaataaa      660

tatggccaat tgggtttagg tactgactgt aaaaagcaaa cttcaccgca gctgcttaag      720

tctttgcttg gaatcccttt catgcaagtt gcagcaggag gagcccatag ttttgtactc      780

accctttctg gagctatctt tggatgggga cgcaacaagt ttggtcagct aggtcttaat      840

gatgaaaatg ataggtatgt tcctaattta ctaaagtcac taagatctca gaaaatagtt      900

tatatttgtt gtggagaaga tcatactgct gctctaacca aggaaggtgg agtgtttact      960

tttggagctg gagggtatgg tcagttgggc cataattcta ccagtcatga aataaaccca     1020

aggaaagttt ttgaacttat gggaagcatt gtcactgaga ttgcttgtgg acggcagcac     1080

acttctgctt ttgttccttc atcaggacga atttactctt ttgggcttgg tggtaatggg     1140

cagctgggaa ccggttcaac aagcaacagg aaaagcccct ttactgtaaa aggaaattgg     1200

tacccctata atgggcagtg tctaccagat attgattctg aagaatattt ctgtgtaaaa     1260

agaattttct cagggggaga tcaaagcttt tcacattact ctagtcccca gaactgtggg     1320

ccaccagatg acttcagatg tcccaatccg acaaagcaga tctggacagt gaatgaagct     1380

ctaattcaga aatggctgag ctatccttct ggaaggtttc ctgtggagat agccaatgag     1440

atagatggaa cgttttcttc ctctggttgc ctaaatggaa gttttttagc tgttagcaat     1500

gatgatcact atagaacagg taccagattt tcaggggttg atatgaatgc tgctaggctt     1560

ttattccaca aacttataca acctgatcat ccgcagatat ctcagcaggt ggcagctagt     1620

ttggaaaaga atcttattcc taaactgact agctccttac ctgatgttga agcattgagg     1680

ttttatctta ctctaccaga atgtcccctg atgagtgatt ccaacaattt cacaacaata     1740

gcaattccct ttggtacagc tcttgtgaac ctagaaaagg caccactgaa agtacttgaa     1800

aactggtggt cagtacttga acctccacta ttcctcaaga tagtagaact ttttaaggaa     1860

gttgtggtac atcttttgaa actctacaag atcggtattc ccccttctga aagaagaatt     1920

ttcaacagtt ttcttcatac tgcattaaag gttttagaaa tactacatag ggtaaatgag     1980

aaaatgggac agattataca gtatgataaa ttttatatac atgaagtaca agaattgata     2040

gacataagaa atgattatat caactgggtc caacagcagg cctatggaat ggatgtcaac     2100

catggattaa ctgagttggc agatatccct gttacaatct gtacatatcc atttgtattt     2160

gatgcccaag caaaaactac tctgttacag accgatgcag tcttacagat gcagatggct     2220

attgatcagg cccacaggca gaatgtctcc tctctttttc tcccagtgat tgaatctgtg     2280

aatccctgct taattctagt ggtgcgtaga gaaaatattg taggagatgc aatggaagtc     2340

cttaggaaaa caaagaacat agattacaag aagccactca aggttatatt tgttggagaa     2400

gatgctgtgg atgcaggagg ggtgcgcaaa gaatttttct tgctcatcat gagggaatta     2460

ttggatccta aatacggcat gtttaggtat tatgaagatt ccaggctcat ttggttttct     2520

gataagacat ttgaagacag tgatttgttc catttgattg gtgttatctg tggcttagca     2580

atttataatt gtaccattgt ggacctccat tttcctttgg ctttatataa gaaactactg     2640

aaaaagaagc catccttgga tgatttgaaa gaactaatgc ctgatgttgg gagaagcatg     2700

caacagttac tggattatcc agaagatgac atagaggaaa cattttgtct taattttacg     2760

atcacagttg aaaactttgg tgcaacagaa gtgaaagagc tggttctaaa tggtgcagac     2820

acagctgtta acaaacaaaa tcggcaagag tttgtcgatg cttatgtgga ttacatattc     2880

aataaatcag tggcttcctt atttgatgct tttcatgcgg gctttcataa ggtctgtgga     2940

ggaaaagtcc ttctgctctt tcagcctaat gaactacaag caatggtcat tggaaataca     3000

aattatgatt ggaaggaact ggaaaagaat acagaataca aaggggaata ttgggcagaa     3060

catcctacga taaaaatttt ttgggaagta tttcacgaat taccattgga aaagaagaaa     3120

cagtttctgt tatttttgac aggtagtgat cgcattccta ttcttggtat gaagagtctg     3180

aaactagtca tccagtccac aggaggtggt gaggagtatc tcccagtttc ccatacttgt     3240

tttaatcttc tggatcttcc aaaatataca gaaaaagaaa ctctacgctc taaactgatc     3300

caagctattg atcacaatga aggcttcagt ttaatataac tttggagtta taactattca     3360

gtttagtgca aaagcattaa actatttgtg tttttcttgt ggtgatgaat tcagcaaggt     3420

gacagaggta ctattataat tcttacttgc agaatgttca atctacgagt gttcatggaa     3480

gccaaaaaat attaaaggaa aatgaacaaa ctgttaatat tattgtacag aaccatggat     3540

tttttttgac catcttctaa taaacatagc aagtattatg aatacattaa agttttacta     3600

acatgaattt taagagtttg catatttcag aaatgatctg gtgtgagtgc atggaaatat     3660

tgcttaattt ttcttcaatc attgagtgaa aaacctttaa ctttggcctg caatagtcat     3720

ttgattattt tttcattttg taaataatgt taagttttgt aataaaatag ttatgttctg     3780

ataccagtac agtttctatg gttgtaattg aacttgaaca gacttttaaa ggttaaaaat     3840

tatgatttaa atcttactct gagactctat aaaaagaaaa aaaaggtagc atggtggaaa     3900

cactatcttt tcttttttgc tagaataagt gtctttgtgc aaacctaaat cacagatagg     3960

gaatatacta cataacctgc agttcttttc tttgtgaatc ctgacacact gatagatggg     4020

ggattgtcga tcagagaact tattaatatt tagtactgga agaactctgt ctccacagtt     4080

gccagtaata aaaagaaaca ttggctacta tgagcaccaa tcactgggtt atagctttca     4140

aaattattga tgctgcagtg ctttagagct atttccttga atttaagaaa caaatcttaa     4200

cagttttatg gtgctgatgc ttagttgtct catgccatta aattgtaaaa gtgagttgat     4260

gcaatacatg tgactttctg ctataatgca aatatttatt ttttaaattt attttaaaat     4320

gccgtgaaaa ctgtttaata aagatttatt gttttaatat tt                        4362


<210> 534
<211> 2623
<212> DNA
<213> Homo sapiens

<400> 534
atgccaagat gcctgccttc cttggtctaa agtgtctggg gaaattgtgc agctctgaga       60

aaagcaaagt cacctcatct gagagaacca gtgccagggg ctcgaacaga aagagactga      120

ttgttgagga ccggagggtc tctgggacct ccttcaccgc tcataggcgt gccactatca      180

ctcatttgct gtatctctgt cccaaggact actgcccacg tgggcgtgta tgtaacagcg      240

ttgatccttt tgtggcccac cctcaggacc ctcaccaccc atcagagaag cctgtcattc      300

actgccataa atgtggggag ccttgcaagg gtgaagtgct tcgggtccag accaaacatt      360

tccacatcaa gtgtttcacc tgcaaagtgt gtggctgtga cctggcacaa gggggcttct      420

tcataaagaa cggagagtat ctctgcaccc tggactacca gcggatgtac gggacacgct      480

gccatggctg tggggagttc gtggagggcg aagtggtgac tgctctgggc aagacctacc      540

atcccaattg ctttgcttgt actatctgca agcgcccgtt tccacccgga gaccgagtca      600

cattcaatgg gagagactgc ctttgtcaac tctgtgcaca gccgatgtcg tccagtccga      660

aagaaaccac cttctccagc aattgtgccg gctgcggaag agatatcaag aatgggcagg      720

cgctgctggc gctggataag cagtggcact tggggtgctt taaatgcaag tcctgcggga      780

aggtcctcac cggggagtac atcagcaagg atggtgctcc gtactgtgaa aaggactacc      840

agggactctt tggggtgaaa tgtgaggcgt gtcaccagtt tatcacaggg aaagtcctgg      900

aggcaggtga caaacattac caccccagct gtgcacgatg cagcagatgc aaccagatgt      960

tcacagaagg agaggaaatg tatcttcaag gctccaccgt ttggcatccc gactgtaagc     1020

aatctacgaa gaccgaggaa aagctgcggc tgccaaacat tcggcgttct tcatccgatt     1080

tcttttattc caaaagtctg attcgacgca caggacggtc tccgtctctg cagcctacca     1140

ggacatcctc ggaaagtatt tattctaggc caggctccag tattcctggc tcaccaggtc     1200

atactatcta tgcaaaagta gacaatgaga tcctggatta caaggattta gcagccattc     1260

cgaaggtcaa ggcaatttat gacattgaac gtccagatct tattacctat gagcctttct     1320

acacttcggg ctatgatgac aaacaggaga gacagagcct tggagagtct ccgaggactt     1380

tgtctcctac tccatcagca gaagggtacc aggatgttcg ggatcggatg atccatcggt     1440

ccacgagcca gggctccatc aactcccctg tgtacagccg ccacagctac actccaacca     1500

cgtcccgctc tccccagcat ttccacagac ctgagctttt gtctcctggt gtgcagaggt     1560

tgtcgtacct gcgcaccagc agcctcagcc ccacccacag cgactcccgc cccaaccccc     1620

ctttccgaca ccacttcatt ccccatatca aaggcaatga gccgtccagc ggccggaact     1680

cccctctccc ttaccggcca gacagccgcc ctctaactcc aacttacgct caggccccta     1740

aacatttcca tgttccagat caaggaatca acatttaccg aaagccaccc atctacaaac     1800

agcatgctgc cttggcagcc cagagcaagt cctcagaaga tatcatcaag ttttccaagt     1860

tcccagcagc ccaggcacca gaccccagcg agacaccaaa gattgagacg gaccactggc     1920

ctggtccccc ctcatttgct gtcgtaggac ctgacatgaa acgcagatct agtggcagag     1980

aggaagatga tgaggaactt ctgagacgtc ggcagcttca agaagagcaa ttaatgaagc     2040

ttaactcagg cctgggacag ttgatcttga aagaagagat ggagaaagag agccgggaaa     2100

ggtcatctct gttagccagt cgctacgatt ctcccatcaa ctcagcttca catattccat     2160

catctaaaac tgcatctctc cctggctatg gaagaaatgg gcttcaccgg cctgtttcta     2220

ccgacttcgc tcagtataac agctatgggg atgtcagcgg gggagtgcga gattaccaga     2280

cactcccaga tggccacatg cctgcaatga gaatggaccg aggagtgtct atgcccaaca     2340

tgttggaacc aaagatattt ccatatgaaa tgctcatggt gaccaacaga gggcgaaaca     2400

aaatcctcag agaggtggac agaaccaggc tggagcgcca cttagcccct gaagtgtttc     2460

gggaaatctt tggaatgtcc atacaggagt ttgacaggtt acctctttgg agacgcaacg     2520

acatgaagaa aaaagcaaaa ctcttctaag tcccactcgt gaatggcaat tagagaaagg     2580

actgacagtg gcggtgcccc ataggatgtc atattgaggc cca                       2623


<210> 535
<211> 1109
<212> DNA
<213> Homo sapiens

<400> 535
aagccccgga agtacttgtt gcctgagcag tgggctgctt aggaagagaa ggtcagagtt       60

cgcgggggca gaggcattct tgccgctggc ccagtcacta tgtagtggag gggcagacac      120

cctcccgcaa attctggaag gttcttagtc tcgactaggg cagtagcccc aggactccta      180

gtcgccggct tcaggtcact gccggctgaa cggagctgcc gtcgccatgt ttggctgctt      240

ggtggcgggg aggctggtgc aaacagctgc acagcaagtg gcagaggata aatttgtttt      300

tgacttacct gattatgaaa gtatcaacca tgttgtggtt tttatgctgg gaacaatccc      360

atttcctgag ggaatgggag gatctgtcta cttttcttat cctgattcaa atggaatgcc      420

agtatggcaa ctcctaggat ttgtcacgaa tgggaagcca agtgccatct tcaaaatttc      480

aggtcttaaa tctggagaag gaagccaaca tccttttgga gccatgaata ttgtccgaac      540

tccatctgtt gctcagattg gaatttcagt ggaattatta gacagtatgg ctcagcagac      600

tcctgtaggt aatgctgctg tatcctcagt tgactcattc actcagttca cacaaaagat      660

gttggacaat ttctacaatt ttgcttcatc atttgctgtc tctcaggccc agatgacacc      720

aagcccatct gaaatgttca ttccggcaaa tgtggttctg aaatggtatg aaaactttca      780

aagacgacta gcacagaacc ctctcttttg gaaaacataa tttgaataaa ataattttta      840

atggattctg aaatttgtca tgttttgaag ataactgact ccatctaaaa gtatgaggtc      900

aaaggatcac gaaacctaag tttaaaaact gcttagagac tgaagcttaa ttaaaaatct      960

ttattaaaaa ttaaaaacat tgaaaaatga aaatatgttc atcattaaag acttttttcc     1020

ccttaagctt aaaataccat tcaaaggcaa gacattttgt tttggctatg attcattttt     1080

tttacttaaa aataaaacct ataccaaac                                       1109


<210> 536
<211> 2955
<212> DNA
<213> Homo sapiens

<400> 536
atacaatgcc gcaaagcgca gggctgatct ccgtctccgc ccccagctgc tttctccgag       60

aggaggtggc tgagtcgggg gcgggctggg agggctgtcg gtgggccagt ctgcgtagcg      120

acggcccgtc ccctgcgcac ggacgccggg aagaaggggg tggggccacg tttgcgtccg      180

cgccatcagg cccgagatag cggcgaggtc cgctttcagt gtatggtttt ccctgccaaa      240

cggttctgct tggtgccatc catggagggc gtgcgctggg ccttttcctg cggcacttgg      300

ctgccgagcc gagccgaatg gctgctggca gtgcgatcga ttcagcccga ggagaaggag      360

cgcattggcc agttcgtctt tgcccgggac gctaaggcag ccatggctgg tcgtctgatg      420

ataaggaaat tagttgcaga gaaattgaat atcccttgga atcatattcg tttgcaaaga      480

actgcaaaag gaaaaccagt tcttgcaaag gactcatcga atccttaccc gaatttcaac      540

tttaacatct ctcatcaagg agactatgca gtgcttgctg ctgaacctga gctgcaagtt      600

ggaattgata taatgaagac tagttttcca ggtcgtggtt caattccaga attctttcat      660

attatgaaaa gaaagtttac caacaaagaa tgggaaacaa tcagaagctt taaggatgag      720

tggactcagc tggatatgtt ttataggaat tgggcactta aggaaagctt cataaaagcc      780

attggtgttg gactaggatt tgaattgcag cggcttgaat ttgatctatc tccattaaac      840

ttggatatag gccaagttta taaagaaaca cgtttattcc tggatggaga ggaagaaaaa      900

gaatgggcat ttgaggaaag caaaatagat gagcaccatt ttgttgcagt tgctcttagg      960

aaacccgatg gatctagaca tcaggatgtt ccatctcagg atgattccaa accaacccag     1020

aggcaattta ctattctcaa ctttaatgat ttaatgtcat ctgccgttcc catgacacct     1080

gaagatcctt cattttggga ctgtttttgc ttcacagaag aaattccaat acgaaatggt     1140

acaaagtcat gatgattccc tgagtaacaa agggaaatga aaactgtttg tgatcttccg     1200

tattcactga aaaataaatg cttgtttagt atcaaatttt atttcacgaa agttttttta     1260

aagaacagaa acttttccaa ttaaaaaaaa aaagcagact tctggttcaa gatagctcac     1320

tggaatacat gtttacctct ttctttccta aattgcattg aattgatagg aaggatggcg     1380

gaatcttaaa gtgatacatg ctaactgtag aaaaaaatag aaaatgcaca taagcaaaag     1440

gaaacattta aatgctatct ttcaaagata actactctta aaaccttgag tatcttttca     1500

gacctttttc ttggcaaatg aatccatatt gacatatttg atttttttaa aaacatggaa     1560

acgtactgtt ttgtaaattc tttttaactg cacatctact gttcataaat atacctctgt     1620

aacataactt tttgtggttc taatgtactc tgttgtatag ctaatacaag ttaggatgct     1680

tttggccaga ggtaacagtg tccaaatata attggcctaa gtaacctagg aaattgtttg     1740

acataacaca gggttcaggg gtgtcattaa agacacactt tttttgcctt gacctcagtt     1800

ggtttgtttt gccttaggct attccacctc tcgatcacaa gagctgctgc tataacttcc     1860

agttttacat ctttgtaaaa ttgtatctca aaggcagaaa aggccatttc gtctctcatt     1920

tgttttatcc atgaggaaga tttttaacaa aagcctccag aagatttccc ctcagtttcc     1980

attgacttag atcaggttac agagaaaggc aatgtctgac atttttggtc tctgttagaa     2040

gtagactctg ttgaaaagaa agaagctaag ctaggtgtga agaatggaat tggaagccca     2100

ctgccttccc ataagaaagg tttaccataa tttactcact tttttctgtg ttagacattt     2160

tgattatctg cagtttatta ctacaagcag tggcagagtg aatgtccttg tacattttga     2220

gttacatgct taattatgtc cttgagaaag tttctaaaag tggaatgatt ggtttgactg     2280

gttcataggg ctttaattat acaatttacc cctctaatta gtactatatg tatgtgactt     2340

ccctccccct gccagaatac tccttggtca attgtaggta ttctttttgg tttaattttt     2400

gccaatgtaa ttaaaaaatg gtatgtcatt tttaaaattt gtatttcttt cattacaaat     2460

aagattgtta tgtcagtatt gttattggct tttcgtattc ctcttaacgt gaaccgtctg     2520

ttcattgttt ttacctgttt tcgttttagc aagtagtact taatttaaag tgtgaactta     2580

atatataaga tgccaggacc atcatattga tgacaaaaat ctattatgtg gttgtagtgc     2640

atgtcttgga gttaaactct taagtatcaa gaagtaaaat aatttcattg tttctgttac     2700

taacattaaa agtgtgcaaa ttgtataaaa ttaggtactt cgattagtaa aagaaaaaaa     2760

tttgaatgtt tttttttttt attttattaa gcatgcccag ttatgccaag catagtaaat     2820

aaaggtcaag tagcatttat aatagaggaa gtattgttat ccctagcatg agtgtaatgg     2880

tgatatgaaa aactttgtct tgtcattata ataataaaaa aatgaacatt tattatggaa     2940

tttctatgag cctga                                                      2955


<210> 537
<211> 2164
<212> DNA
<213> Homo sapiens

<400> 537
gccgggccgg agcggggtgg gtaggggacg cgaggcggag cggggcccca cacaggccgc       60

ggcggctggc tcgggcccct acggtcccgg cggcggctgg aggaggaagc caggcggctg      120

gcggaggagg agagacggag gaggccgaga ccggagcgcc gctcgccgca gacttacttc      180

cccggctcag cagggaaagg ttcctagaag gtgagcgcgg acggtatgca aagttgtgaa      240

tccagtggtg acagtgcgga tgaccctctc agtcgcggcc tacggagaag gggacagcct      300

cgtgtggtgg tgatcggcgc cggcttggct ggcctggctg cagccaaagc acttcttgag      360

cagggtttca cggatgtcac tgtgcttgag gcttccagcc acatcggagg ccgtgtgcag      420

agtgtgaaac ttggacacgc cacctttgag ctgggagcca cctggatcca tggctcccat      480

gggaacccta tctatcatct agcagaagcc aacggcctcc tggaagagac aaccgatggg      540

gaacgcagcg tgggccgcat cagcctctat tccaagaatg gcgtggcctg ctaccttacc      600

aaccacggcc gcaggatccc caaggacgtg gttgaggaat tcagcgattt atacaacgag      660

gtctataact tgacccagga gttcttccgg cacgataaac cagtcaatgc tgaaagtcaa      720

aatagcgtgg gggtgttcac ccgagaggag gtgcgtaacc gcatcaggaa tgaccctgac      780

gacccagagg ctaccaagcg cctgaagctc gccatgatcc agcagtacct gaaggtggag      840

agctgtgaga gcagctcaca cagcatggac gaggtgtccc tgagcgcctt cggggagtgg      900

accgagatcc ccggcgctca ccacatcatc ccctcgggct tcatgcgggt tgtggagctg      960

ctggcggagg gcatccctgc ccacgtcatc cagctaggga aacctgtccg ctgcattcac     1020

tgggaccagg cctcagcccg ccccagaggc cctgagattg agccccgggg tgtgctaaag     1080

aggcagtaca ccagtttctt ccggccaggc ctgcccacag agaaggtggc tgccatccac     1140

cgcctgggca ttggcaccac cgacaagatc tttctggaat tcgaggagcc cttctggggc     1200

cctgagtgca acagcctaca gtttgtgtgg gaggacgaag cagagagcca caccctcacc     1260

tacccacctg agctctggta ccgcaagatc tgcggctttg atgtcctcta cccgcctgag     1320

cgctacggcc atgtgctgag cggctggatc tgcggggagg aggccctcgt catggagaag     1380

tgtgatgacg aggcagtggc cgagatctgc acggagatgc tgcgtcagtt cacagggaac     1440

cccaacattc caaaacctcg gcgaatcttg cgctcggcct ggggcagcaa cccttacttc     1500

cgcggctcct attcatacac gcaggtgggc tccagcgggg cggatgtgga gaagctggcc     1560

aagcccctgc cgtacacaga gagctcaaag acagcgcatg gaagctccac aaagcagcag     1620

cctggtcacc ttttctcttc caagtgccca gaacagcccc tggatgctaa caggggcgcc     1680

gtaaagccca tgcaggtgct gttttccggt gaggccaccc accgcaagta ctattccacc     1740

acccacggtg ctctgctgtc cggccagcgt gaggctgccc gcctcattga gatgtaccga     1800

gacctcttcc agcaggggac ctgagggctg tcctcgctgc tgagaagagc cactaactcg     1860

tgacctccag cctgcccctt gctgccgtgt gctcctgcct tcctgatcct ctgtagaaag     1920

gatttttatc ttctgtagag ctagccgccc tgactgcctt cagacctggc cctgtagctt     1980

ttctttttct ccaggctggg ccgtgagcag gtgggccgtt gagttacctc tgtgctggat     2040

cccgtgcccc cacttgccta ccctctgtcc tgccttgtta ttgtaagtgc cttcaatact     2100

ttgcattttg ggataataaa aaaggctccc tcccctgccc ctcagcttct ctctggtttt     2160

ctca                                                                  2164


<210> 538
<211> 3927
<212> DNA
<213> Homo sapiens

<400> 538
gaggggtcga gcctgggcag tacaggcggc ggtgcgcact ctgcggcggc ctctgcgcct       60

cgggcgggcg ggagagagag gccgcggccg ccagcgtggg gatgtctagg agctcgaagg      120

tggtgctggg cctctcggtg ctgctgacgg cggccacagt ggccggcgta catgtgaagc      180

agcagtggga ccagcagagg cttcgtgacg gagttatcag agacattgag aggcaaattc      240

ggaaaaaaga aaacattcgt cttttgggag aacagattat tttgactgag caacttgaag      300

cagaaagaga gaagatgtta ttggcaaaag gatctcaaaa atcatgactt gaatgtgaaa      360

tatctgttgg acagacaaca cgagtttgtg tgtgtgtgtt gatggagagt agcttagtag      420

tatcttcatc tttttttttg gtcactgtcc ttttaaactt gatcaaataa aggacagtgg      480

gtcatataag ttactgcttt cagggtccct tatatctgaa taaaggagtg tgggcagaca      540

ctttttggaa gagtctgtct gggtgatcct ggtagaagcc ccattagggt cactgtccag      600

tgcttagggt tgttactgag aagcactgcc gagcttgtga gaaggaaggg atggatagta      660

gcatccacct gagtagtctg atcagtcggc atgatgacga agccacgaga acatcgacct      720

cagaaggact ggaggaaggt gaagtggagg gagagacgct cctgatcgtc gaatccgagg      780

atcaggcatc agtggactta tcgcacgacc agagtgggga ttccctcaac agtgatgaag      840

gagacgtgtc ttggatggag gagcagctgt cctacttctg tgacaagtgc caaaaatgga      900

taccagccag tcagctgagg gaacagctca gttaccttaa gggtgataat ttttttaggt      960

ttacttgttc ggattgctca gcagatggca aggagcagta tgaaaggctg aagctgacat     1020

ggcagcaagt cgtcatgttg gcaatgtaca acttgtctct ggaaggaagt ggacgtcaag     1080

gttatttcag gtggaaagaa gatatctgtg cttttattga gaaacattgg acttttttac     1140

tagggaatag gaaaaagacg tctacctggt ggagcaccgt ggcaggttgc ctcagcgtgg     1200

gaagtcccat gtacttccgt tcaggtgctc aggaatttgg agagccagga tggtggaaac     1260

ttgttcataa caagccccca acgatgaaac ctgaaggaga gaagttgtct gcctctactt     1320

tgaaaataaa agcagcctca aaaccaactt tagatcccat cattactgtt gagggactta     1380

gaaaacgagc aagtcggaat cctgtggaat ctgccatgga attaaaagag aaaaggtctc     1440

gaactcagga agcaaaagac attagaagag cccagaagga ggccgctggc tttcttgaca     1500

ggagcacatc ttctacccct gtaaaattca taagccgagg ccgcaggcca gatgtgattc     1560

tggaaaaagg cgaagtgatt gacttttcct ccttgagctc ctctgaccgc accccgctga     1620

caagcccatc tccttctcct tctctggatt tctctgcccc tggtacacct gcctctcatt     1680

ctgccacacc tagcttgctt tcagaagcag atctgattcc agatgtgatg cccccacaag     1740

ccttgtttca tgatgacgat gagatggaag gcgatggagt catagaccca gggatggagt     1800

acgtcccacc ccctgctggg tcagtagctt ctgggccagt ggttggggtc agaaagaagg     1860

tcagaggccc tgaacagata aagcaggagg tagagagtga ggaggaaaaa cccgacagga     1920

tggatattga cagtgaagac acagattcaa acacatcttt gcaaacaagg gctagagaaa     1980

agaggaagcc tcagctggag aaggacacaa agccgaaaga gcccaggtat actcccgtga     2040

gcatctacga ggaaaagctg ctgctcaaga ggctggaagc ttgtcccggt gctgttgcca     2100

tgactccgga agctcggaga ctgaaacgca aactgattgt cagacaagcg aaaagggata     2160

ggggattacc actttttgac ttggatcaag ttgttaatgc tgctcttttg ttagttgacg     2220

ggatttatgg agccaaagaa ggaggaattt ccagacttcc agctggacaa gccacgtaca     2280

gaaccacctg tcaggacttc agaatccttg accgatacca gacttccttg ccgtccagga     2340

agggatttcg acaccagacc accaagtttt tgtatcgctt ggtaggatca gaagatatgg     2400

ctgtggacca gagtattgtc agcccttata cctctcggat cttgaaacct tatatcaggc     2460

gtgattatga aacaaagcca cccaaactgc agctcctgtc acagattcgt tcccacctgc     2520

acaggagcga ccctcactgg acgccggagc ccgacgcacc tctcgattac tgttatgtgc     2580

ggccaaatca catcccaacg atcaactcca tgtgtcagga gtttttttgg cctggcattg     2640

acctgtctga gtgtctgcag tacccagact tcagtgttgt tgttctttat aaaaaagtca     2700

tcattgcctt tggcttcatg gttcctgatg tgaaatacaa tgaagcttac atttcatttc     2760

tgttcgtcca ccctgaatgg agaagagcag ggattgcaac tttcatgatc tatcatctga     2820

ttcagacctg catgggcaag gacgtaaccc ttcacgtctc agcaagcaac cctgctatgc     2880

tactgtacca gaagtttgga ttcaagactg aagaatatgt attagatttc tatgataaat     2940

attacccatt ggagagtaca gagtgtaaac acgcattctt tctgaggctc cggcgctgat     3000

gcgaatacag ctcacagaga aacgcatgtg ctattggaga acaggtcttt gtggagatct     3060

aaaggcagtg attgatttca cagggagctc taatctctgt gattacatgg tccttcaaac     3120

tcccaaccaa agtgagaaaa gcggcatgca gtgaaatgag cagtgagcag ccctttagca     3180

aaatcgccct ccagtccttc ctggagatgc cttcagccag catcccagac tccacagtta     3240

tttatgaatg atgtcgtgat tctccctcca cctgacagtt tgtaagagtg aaagagcatc     3300

taacctgatg ctcttggaga gagataacct gtctgtcata acttaaagga tgagaaaatg     3360

tggtgtagct attaaagatt catgcagtcc caaaaggcac tgtcctggga tgatgagaga     3420

ttataaggtg atttcataaa aggaatccaa ccctgtgccc ggccattgat gtgttgtcat     3480

tgaatccagg aggatttcta gggcactgaa gttttgttgt ttcttttgct gactttggtt     3540

acagtcagaa aaaataaact agatgtttgt gtctacatgt tctacctgtt gtacctatta     3600

gcatcttcct gcagggactt gggcccatgg cctgggaggt tggtttggga ttggggttgt     3660

tgggcagcct gccattcacc tggcctatcc tggcccttct catgcccaag acagttgttt     3720

cacaggagtg gaagtgtggg tgatgcaagt agaaccctct agatgtaccc tgtgtggtct     3780

gcaggactgg actgtttgct gtgtttgtgg atgttggcga tagactgtca attaggttgt     3840

ttgtgatcca acaagaacat ttccaaaagt atctaggtgt tctcaaataa aaagctttct     3900

ttgcacaacc catggccaga gcgtcaa                                         3927


<210> 539
<211> 3698
<212> DNA
<213> Homo sapiens

<400> 539
agttttgaaa atcatagttt tcgcccgcgc tgcgccgcct ggttgctcct cccgtgcggt       60

gagtcccgaa ggcccggagc caagtgggtc tgggcaagcg gggccttacc tagggatacc      120

accggacttg gatcggagca gccttcaggg gacgtggcgc agtcgaacag agccaccatg      180

gggacgacgg ccccagggcc cattcacctg ctggagctat gtgaccagaa gctcatggag      240

tttctctgca acatggataa taaggacttg gtgtggcttg aggaaatcca agaggaggcc      300

gagcgcatgt tcaccagaga attcagcaaa gagccagagc tgatgcccaa aacaccttct      360

cagaagaacc gacggaagaa gagacggatt tcttatgttc aggatgaaaa cagagatccc      420

atcaggagaa ggttatcccg cagaaagtct cggagcagcc agctgagctc ccgacgcctc      480

cgcagcaagg acagtgtaga gaagctggct acagtggtcg gggagaacgg ctccgtcctg      540

cggcgtgtga cccgtgctgc ggctgcagct gccgcggcta ccatggcatt ggctgcacct      600

tcttcaccca cccctgagtc tcccacgatg ctgactaaga agcccgagga taaccacacc      660

cagtgccagc tggtgcctgt ggtggagatc ggcatcagtg agcgccagaa tgctgagcag      720

catgtcaccc agctcatgtc caccgagcct ctgccccgca ctctgtcccc gactccagct      780

tcagccacag ctccaacctc ccagggcatc ccgacatcag atgaggaatc aacacctaag      840

aagtcgaagg ccaggatact ggagtccatc acagtgagct ccctgatggc tacaccccag      900

gaccccaagg gtcaaggggt cgggacgggg cggtctgcgt ctaagctcag gattgcgcag      960

gtctcccctg gcccacggga ctcgccagcc tttccagatt ctccatggcg ggagcgggtg     1020

ctggctccca tcctgccgga taacttctcc acgcccacgg gctctcgcac ggactctcaa     1080

tcggtgcggc acagcccgat cgccccgtct tccccgagtc cccaagtctt agcccagaag     1140

tactctctgg tggccaaaca ggaaagtgtt gtccgcaggg cgagcagaag gcttgccaag     1200

aagactgccg aagagccagc tgcctctggc cgcatcatct gtcacagtta cctggagagg     1260

ctcctgaatg ttgaggtgcc ccagaaagtt ggttctgagc agaaggaacc ccccgaggag     1320

gctgagcctg tggcggcagc tgagccagag gtccctgaga acaatggaaa taactcgtgg     1380

ccccacaatg acacggagat tgccaacagc acacccaacc cgaagcctgc agccagcagc     1440

ccggaaacac cctctgcagg gcagcaagag gccaagacgg accaagcaga tggacccaga     1500

gagccaccgc agagtgccag gaggaagcgc agctacaagc aggccgtgag tgagctggac     1560

gaggagcagc acctggagga tgaggagctg cagcccccca ggagcaagac cccttcctca     1620

ccctgcccag ccagcaaggt ggtacggccc ctccggacct ttctgcacac agtgcagagg     1680

aaccagatgc tcatgacccc gacctcagcc ccacgcagcg tcatgaagtc ctttattaag     1740

cgcaacactc ccctgcgcat ggaccccaag gagaaggagc ggcagcgcct ggagaatctg     1800

cggcggaagg aggaggccga gcagctgcgc aggcagaagg tggaggagga caagcggcgg     1860

cggctggagg aggtgaagct gaagcgtgag gaacgcctcc gcaaggtgct gcaggcccgc     1920

gagcgggtgg agcagatgaa ggaggagaag aagaagcaga ttgagcagaa gtttgctcag     1980

atcgacgaga agactgagaa ggccaaggag gagcggctgg cagaggagaa ggccaagaaa     2040

aaggcggcgg ccaagaagat ggaggaggtg gaagcacgca ggaagcagga agaggaggca     2100

cgtaggctca ggtggctgca gcaggaggag gaagagcggc ggcaccaaga gctgctgcag     2160

aagaagaagg aagaggagca ggagcggctg cggaaggcgg ccgaggctaa gcggctggca     2220

gagcagcggg agcaggagcg gcgggagcag gagcggcgcg agcaggagcg gcgcgagcag     2280

gagcggcggg agcaggagcg gcgcgagcag gagcgacagc tggcagagca ggagcgtcgg     2340

cgggagcagg agcggctcca ggccgagagg gagctgcagg agcgggagaa ggccctgcgg     2400

ctgcagaagg agcagctgca gagggaactg gaggagaaga agaagaagga agagcagcag     2460

cgtctggctg agcggcagct gcaggaggag caagagaaga aagccaagga ggcagcaggg     2520

gccagcaagg ccctgaatgt gactgtggac gtgcagtctc cagcttgtac ctcatatcag     2580

atgactccgc aagggcacag ggcccctccc aagatcaacc cagataacta cgggatggat     2640

ctgaatagcg acgactccac cgatgatgag gcccatcccc ggaagcccat ccccacctgg     2700

gcccgaggca ccccgctcag ccaggctatc attcaccagt actaccaccc accgaacctt     2760

ctggagctct ttggaaccat tctcccactg gacttggagg atatcttcaa gaagagcaag     2820

ccccgctatc acaagcgcac cagctctgct gtctggaact caccgcccct gcagggcgcc     2880

agggtcccca gcagcctggc ctacagcctg aagaagcact gaggctggcc tgcggccttc     2940

ttggcagcct cgcctcctgt ccatgtctat ctgtctgtct gtcggtctct gtcttggtct     3000

gttgccctcc ttcttggcat gccattgtgg agggcttggc caggtgtata taaacgtcct     3060

ctgtgctggg tgtttctgct gcaggtggca ggtggcccca ggcctgtttg gaggatgggc     3120

tgggtgggtg ggtggggaag aaatgggccc agccccacat ggcctgcaga cagtgctctg     3180

taaatagttg ttttaattta gctgaatgtt agcattttag tctttggcat tttagcgttt     3240

gggaggtaga ttaataaagt atattccttc aagcctgctg ttgataccat gaagactggg     3300

cgcctcagtc ccagccctgt agctgtgtgt cttgggccac cagtggcctg caggacgaag     3360

gtactgttcc atcacctgcg gtgtgcctca ggatcaccag gtgcaggccc ccaccctcgg     3420

agatgctgct gcagtgagtg gttccactgc ctggataacc cttgaggaac acgtcagtta     3480

ctgtcacgat ggggcaggtg gagctccttc ctattttttg gggtgctccc tgtttgtaaa     3540

ggggagtttg ttcattggga aagacctggg tcttgacacg gccctgccac ttagtcccct     3600

accctctcca ttccccaggc tccacccgtg ctgctcaggt gcaaatggac ttgagagcat     3660

ctatgtgctg gtgaagcatg aggtctgagt agaaaagg                             3698


<210> 540
<211> 4969
<212> DNA
<213> Homo sapiens

<400> 540
gcggtacggg ggtggtgccg cgctcctggc cccgcgcggg cggacggcgg aggcgcctcc       60

cagcctgcta tgggatggat gaagaagaga accactatgt ctcgcagctc agggaagtct      120

acagcagctg cgacaccacg gggactggct ttctggaccg ccaggagctg acccagctct      180

gccttaagct tcacctggag cagcagctgc ccgtcctcct gcagacgctt ctcggaaacg      240

accatttcgc cagggttaac tttgaggaat ttaaggaagg ttttgtggct gtgttgtctt      300

caaatgctgg tgttcgcccc tcagatgaag acagtagttc tttggaatca gctgcctcca      360

gtgccatccc tccaaagtat gtgaatggtt ctaagtggta tggccgtcgg agccggcctg      420

agctatgtga cgctgccaca gaagccagac gcgtgccgga gcagcaaacc caggccagcc      480

tgaaaagtca cctctggcgc tcagcgtctc tggagagcgt ggagagtccc aagtcagatg      540

aagaggccga gagcactaaa gaagctcaga atgaattatt tgaagcacaa ggacagctgc      600

agacctggga ttctgaggac tttgggagcc cccagaagtc ctgcagcccc tcctttgaca      660

ccccagagag ccagatccgg ggcgtgtggg aagagctggg ggtgggcagc agcggacacc      720

tgagcgagca ggagctggct gtggtctgcc agagcgtcgg gctccaggga ctcgagaaag      780

aggaactcga agacctgttt aacaaactgg atcaagacgg agacggcaaa gtgagtcttg      840

aggaattcca gcttggcctc ttcagtcatg agcccgcgct acttctagag tcttccactc      900

gggttaaacc gagcaaggct tggtctcatt accaggtccc agaggagagc ggctgccaca      960

ccaccacaac ctcatccctc gtgtccctgt gctccagcct gcgcctcttc tccagcattg     1020

acgatggttc tggcttcgct tttcctgatc aggtcctggc catgtggacc caggagggga     1080

ttcagaatgg cagggagatc ttgcagagcc tggacttcag cgtggacgag aaggtgaacc     1140

ttctggagct gacctgggcc cttgacaacg agctcatgac agtggacagt gccgtccagc     1200

aggcagccct ggcctgctac caccaggagc tgagctacca gcaagggcag gtggagcagc     1260

tggcaaggga gcgtgacaag gcaaggcagg acctggagag ggccgagaag aggaacctgg     1320

agtttgtgaa agagatggac gactgccact ccaccctgga gcagctcacg gagaagaaaa     1380

tcaagcatct ggagcagggg taccgggaaa ggctgagcct cctgcggtct gaggtggagg     1440

cggagcgaga gctgttctgg gagcaggccc acaggcagag ggccgcgctg gagtgggacg     1500

tggggcgcct gcaggctgag gaggctggcc tccgcgagaa gctgaccctg gccctgaagg     1560

aaaacagtcg cctacagaag gagattgtgg aagtggtgga aaagctttcg gattcggaga     1620

ggctggccct gaagctgcag aaggacctgg agtttgtgct gaaggacaag ctggagccac     1680

agagtgcaga gctcctggcc caggaggagc ggttcgcagc agtcctgaag gaatacgagc     1740

tcaagtgccg ggacctgcag gaccgcaacg atgagctgca agctgagctg gaaggcctgt     1800

gggcgcggct gcccaagaac cggcacagcc cctcatggag cccggatggg cgcagacggc     1860

agctccctgg actcggccca gcaggcattt cattcctggg taattctgct ccagtgagta     1920

tagaaacgga gctgatgatg gagcaggtaa aggagcatta ccaagacctc aggacccagc     1980

tggagaccaa ggtaaattac tacgaaaggg aaattgcggc actgaaaagg aactttgaga     2040

aggagaggaa ggacatggag caggctcgca ggcgcgaggt cagcgtgctg gagggtcaga     2100

aggccgacct ggaggagctc cacgagaagt ctcaggaggt catctggggc ctgcaggagc     2160

agctgcagga cacagcccgc ggccccgagc ctgagcagat gggcctggca ccctgctgca     2220

cccaggcact gtgtggcctg gccctgcggc atcacagcca cctgcagcag atcaggagag     2280

aggctgaggc ggagctgagt ggagagctgt cggggctggg agccctgccc gctcgcagag     2340

acctgacctt ggagctggag gagccgccgc agggacccct gccacgcggg agccagaggt     2400

cggagcagct ggagctggag agggcactga agctgcagcc ctgtgcgagc gagaagcgcg     2460

cccagatgtg cgtatcgttg gccctcgagg aggaggagtt ggagcttgcc cgcgggaagc     2520

gagtggacgg gccctccctg gaagcagaga tgcaggccct gccgaaagat gggctggtgg     2580

caggaagtgg ccaggagggc acacgtggcc tcctaccact gcgtccgggc tgtggggagc     2640

ggccactggc ctggctggcc ccaggtgatg gcagagagtc tgaggaggcg gcaggagccg     2700

ggcctcgccg caggcaagcc caggacacag aagctacgca gagcccggcc cccgcccctg     2760

ccccggcatc ccacggcccc tcagagaggt ggtcacgcat gcagccctgt ggagtggatg     2820

gggatattgt cccaaaggag ccagagcctt tcggcgcgag cgcagcgggg ctggagcagc     2880

ctggagcccg ggagctgcct ctgctgggaa cagagagaga cgcctcgcaa acccagccac     2940

ggatgtggga gccacccctg aggccggccg cttcgtgcag gggacaggct gagaggctac     3000

aggccattca ggaagagcga gcacgaagct ggagcagggg cacccaggag caggcctcgg     3060

agcagcaggc ccgggccgag ggcgccctgg agcctgggtg tcacaagcac agtgtggagg     3120

ttgccaggag agggtccttg ccatcccacc tccagctcgc agacccgcag ggttcctggc     3180

aggagcagct tgctgcccca gaagaggggg agaccaaaat agcgctggag agagagaagg     3240

atgacatgga aaccaaactt ctacatctgg aagacgtcgt ccgggctctg gagaaacatg     3300

tagatttgag agagaacgac agactggagt tccatagact ttctgaagaa aacactttgt     3360

tgaaaaacga tctgggaagg gttcggcaag agcttgaagc tgcagaaagt actcacgatg     3420

cacagaggaa ggaaattgag gttttaaaga aagacaagga aaaggcctgc tctgagatgg     3480

aggtgctcaa cagacagaat cagaactaca aggatcaatt atcccagctc aatgtcaggg     3540

ttcttcaact gggacaggag gcttctaccc accaggccca aaacgaggag catcgtgtga     3600

ccattcagat gttaacacag agcctggagg aggtggttcg cagtgggcag cagcagagtg     3660

accaaatcca aaaacttaga gttgaacttg aatgcctgaa tcaggaacat cagagcctgc     3720

agctgccatg gtcagagctg acccagaccc ttgaggaaag tcaagaccag gtgcagggag     3780

ctcacctgag gctgaggcag gcccaggccc agcacttgca ggaggtccgg ctggtgcccc     3840

aggaccgtgt ggccgagctg catcgcctgc tcagccttca gggagagcag gccaggaggc     3900

gcctggatgc acagcgggaa gaacatgaga aacagctgaa agccacagaa gagcgggtgg     3960

aagaggcgga gatgattctg aagaatatgg aaatgctcct ccaagagaaa gtggataagc     4020

tgaaggagca gtttgaaaag aacacgaagt ccgacctgct gctgaaggag ctgtacgtgg     4080

agaacgccca cctggtgaga gcacttcagg ccaccgagga gaagcagcga ggcgccgaga     4140

aacaaagccg cctcttggaa gaaaaagttc gcgctctcaa caaactcgtc agtaggattg     4200

cccccgcagc cctctctgtg taaagacaga ttattttcta ggattcattc gaaagcacat     4260

cttttaaatt aagccactgt gctgccttag attccgtggg tcatgagcca tgagtcctgg     4320

gacatctgag gattgggatt ctttgttcac cccgcagata gttaatgaat ggtctgccct     4380

gggcaagatg gaggtggggg ctgggggaat atgcatgttg cagaagccgg cgtttttatt     4440

agcggtcctg agtaatttcc cttggcaaaa ttcccagttt tgccactctc tggagccaga     4500

tcctgggagc tgtcagcaag gagcaggtaa gtgagcagtt atggacagca ctttccatgt     4560

ggtgcttccg accctggctg tcagagtgaa atgtaaagtc agggctctgt acagttttgc     4620

catttcactg ttctgcttta agcttagctt attagaactc ttggtggagg gtgcgtacac     4680

acattccaga aaaggcttca ctcgctggga acgtcaaccc agcgagaaag gaggggaagc     4740

cccttctccg gggaccttat ctgtggactc aggaatgatg gtgtttattg caaatgcaca     4800

atctttttcc cattgaaatg tcatcacact ggaaattgta ctatatgtaa aaaaaaaaaa     4860

aagtatagtt ttatatttga aatgtatgca aattatggcc atatggctga ttggaatgta     4920

ctactgtaat ataaaaagtc actgtatttg caataaattc ttttctatt                 4969


<210> 541
<211> 5630
<212> DNA
<213> Homo sapiens

<400> 541
ttgcgcgctg cagggcaaca ccccggcgtc cctggaagct gggggagcgg gagaaataac       60

tttatttgga ctgagagctg gagaatgaga ataggacctg agagtatatt gggctaagga      120

ggagaggtgt ttgagcccag atgagtcatg gctggacgac ccctccgcat aggagatcag      180

ctggttctgg aagaagatta tgatgagacc tacattccta gtgagcaaga aattcttgaa      240

tttgcccggg agattggtat tgatcccatc aaggaaccag aactgatgtg gctggcgcga      300

gagggcatcg tggccccact gcctggagag tggaaaccat gccaggacat cacaggtgac      360

atttactatt tcaacttcgc caacgggcag tctatgtggg accatccatg tgacgaacac      420

tatcggagct tggtgatcca agagcgggca aagctgtcaa cttctggggc cattaagaag      480

aagaaaaaaa aaaaggaaaa gaaagacaag aaggacagag acccccccaa aagttcgctg      540

gccttgggtt cctcattagc cccagttcat gttcctcttg ggggcctggc tcctttacga      600

ggtcttgtgg ataccccacc ctctgctctt cgtggatctc aaagcgtgag cctggggagc      660

tcagtggagt ctggacgtca gcttggagaa ctcatgctgc cttcacaggg tctcaagacc      720

tctgcttata caaagggtct cttgggctcc atatatgagg acaagactgc tctcagcctc      780

ttgggtttag gagaagaaac caatgaggag gatgaggagg aaagtgacaa ccagagtgtc      840

cacagctcaa gtgagcctct taggaaccta cacctggaca ttggggcact ggggggtgac      900

tttgagtatg aggagtctct gagaacaagc cagccagagg agaagaagga tgtttctctg      960

gattcagatg ctgccggtcc ccctactccc tgcaagccct ccagcccagg tgcagacagc     1020

agtctgagca gtgctgttgg caaagggcga cagggaagtg gagcaagacc tggtcttcca     1080

gaaaaagagg aaaatgagaa gagtgaacct aagatttgca ggaatctggt gacccccaag     1140

gcagacccta caggcagtga gcctgccaaa gcctctgaaa aggaagcacc agaggacaca     1200

gtagatgcag gagaggaggg ttccaggagg gaagaggcag ccaaggagcc aaagaagaag     1260

gcttctgctc tggaagaggg cagttcagac gccagccaag aactggaaat tagtgaacac     1320

atgaaggaac cacagctctc agactccata gcttctgacc ccaagtcctt ccatggcctg     1380

gacttcggtt ttcgcagccg gatctcggag cacctgctgg atgttgatgt gctttcccca     1440

gtcctgggtg gagcttgtcg gcaggcccag caaccactgg gaatagaaga caaggatgac     1500

agccagtcca gccaagatga gctgcagagc aagcagtcca aaggcctgga ggagaggtta     1560

tctcctccac ttccacacga ggagcgggcc cagagtcccc ctcgcagcct ggccactgaa     1620

gaagagcctc cccagggccc cgaggggcag cccgagtgga aggaggcaga ggagcttggg     1680

gaggactctg cagccagcct cagcctgcag ctgtccctcc agagggagca ggccccaagc     1740

ccacctgctg cctgtgagaa gggcaaggag cagcattccc aggccgagga gctgggccct     1800

gggcaggaag aggcagagga tcctgaggag aaggtggcgg tcagccccac cccgccagtc     1860

tctccagagg tgcgatccac agagcctgtg gctcccccag agcagctctc agaggctgca     1920

ctaaaggcca tggaagaggc agtggcccaa gtactcgagc aagaccagag gcacctgctg     1980

gaatccaagc aagagaagat gcagcaactg cgggagaagc tgtgccaaga ggaggaagag     2040

gagatcctcc ggcttcacca gcagaaagag caatctctca gttccttgag ggagcggctg     2100

cagaaagcca ttgaggagga ggaggcccgg atgagagagg aggaaagcca gaggctatcc     2160

tggctccgag ctcaggtcca gtccagcaca caagcagatg aggaccaaat cagggctgag     2220

caagaggctt ccctgcagaa actgagagaa gagttggagt ctcaacagaa ggctgagagg     2280

gccagcttgg aacagaaaaa taggcaaatg ctggagcagc tcaaggaaga gatagaggct     2340

tcggagaaga gcgagcaggc tgccctgaat gctgcaaagg agaaggctct gcagcagctg     2400

agggagcagc tggaagggga gaggaaagaa gctgtggcaa cgctggagaa ggagcacagt     2460

gctgagctgg agcggctctg ctcctcattg gaggccaagc accgggaggt ggtctccagc     2520

ctccagaaga agatacagga agctcaacag aaagaggagg cccagctgca gaagtgcctt     2580

gggcaagtgg agcacagagt tcaccagaag tcttatcacg tggctgggta tgagcacgag     2640

ctcagcagtc tcctgcgaga gaagcgccag gaagtggaag gggagcatga gaggaggttg     2700

gacaagatga aggaggagca ccagcaagtg atggctaagg ccagagagca gtatgaagct     2760

gaggagagga agcagcgggc tgagcttctg gggcacctga ccggagagct ggagcgcctg     2820

cagagggccc atgaacgaga actggagact gtgaggcagg agcaacacaa gcgtcttgag     2880

gacttgcggc gccggcacag ggagcaggaa aggaagctcc aggatttaga gttggacctt     2940

gaaaccagag ctaaagatgt caaggccaga ttggctctgc tggaggtcca ggaggagacc     3000

gcccggaggg agaagcagca gctgcttgat gtgcagaggc aggttgctct gaagagtgag     3060

gaagccacag ccacccatca gcagctggag gaggcacaga aggagcacac ccacctgttg     3120

cagtcaaacc agcagctccg agaaattctt gatgagctgc aggcccgcaa gctgaagctg     3180

gagtcccaag tggatctgct gcaggctcag agccagcaac tgcagaaaca cttcagcagc     3240

ctggaggctg aagctcaaaa gaagcagcac ctgttgagag aagtgacagt tgaggaaaat     3300

aatgcttccc cacattttga gccagatctc catattgagg acctgaggaa atcccttgga     3360

acaaaccaga ccaaagaggt gtcttcttct ctctcccaga gcaaggagga cttatacttg     3420

gacagcctgt cctcccacaa tgtctggcac ctcctctctg ctgagggggt agccctccgt     3480

agtgccaagg agttccttgt gcagcagaca cgctccatgc ggaggcggca gacagctctg     3540

aaagctgccc agcagcattg gcgccatgag ctggccagtg cgcaggaggt ggccaaagac     3600

ccaccaggca tcaaggccct ggaagatatg cgcaagaacc tggagaagga gaccaggcac     3660

ctggatgaga tgaagtcggc catgcggaaa ggccacaacc tgctgaagaa gaaagaggag     3720

aagctgaatc agttggagtc ctctctttgg gaagaggcct cagatgaggg cactctggga     3780

ggatccccca ccaagaaggc agtaaccttc gacctcagtg acatggacag cctgagcagt     3840

gaaagttctg aatctttttc cccgcctcac cgtgagtggt ggcggcagca gaggatcgac     3900

tcaaccccga gtctcacctc ccgcaagatc cacgggctta gccactccct ccggcagatc     3960

agcagccagc tgagcagtgt cctcagcatc ctggacagcc tcaaccctca gtcgccgccg     4020

ccgctcctcg cctccatgcc agcccagctc cctccccggg accctaagag cacccccacc     4080

cccacctact atggctccct ggccaggttc tcagccttat catctgctac acccacgtcc     4140

acccaatggg cctgggattc agggcagggg cccaggctcc cctcctctgt ggctcaaacg     4200

gtggacgact tcctgttgga gaagtggcgc aagtattttc catctggcat cccgctgctc     4260

agcaacagcc ccaccccgct ggagagcagg ctgggttaca tgtctgccag tgagcagctc     4320

cggctcctac agcactccca ttcgcaagtc cctgaggcgg gcagcaccac ctttcagggc     4380

ataattgagg ccaaccggag gtggctggaa cgtgtcaaga atgaccccag gttacctctc     4440

ttctcgtcaa cacccaagcc aaaagctact ttgagcctcc tgcagctggg ccttgatgag     4500

cacaacagag tgaaggtgta tcgcttctga ggccctgagc aggggcttgg ggcagcccag     4560

cctctcctcc acccagacca agtgcctgag gagctgcctg ccttcttcca tctgagaaag     4620

caccctcctt ccccctttga cttgcaggag ccaccaggga ccagggggtt gagtggaaca     4680

gtaaagccac acattctgtg actatataac ctatctcagg ctaaaatgtg tggactcgta     4740

cgagctcttg tcattgacat ggcaagctga tggcgtgcgg tggctgcggg gtatcagggc     4800

cgggagccct ttgggaggaa gggaggcgtt agaggagctg ccttcggagg ctcagggagt     4860

ccctttggag ctggttgttt ccttggccct gcagcgcact gctcggggct cccaaggagg     4920

ttgtgtgtat ggttcttaat tcatcaggac aaagaccccc agcatgtgtg taccctggga     4980

cccgatttct ctgggcccac atctatctcc aatacctcag cctcagatca gaccctttct     5040

tttttgtctt tcttctctta atttttaaat gcctcttttc ttgagcattc catctctctt     5100

tttgaccctc tcaggactgg gcttagctgt ccagagccct gccggagggt gctgggggct     5160

gtccctctgc aggcactgtg ttttcctcag gggctgtcct cagaacaccc ctcctgctcc     5220

ctggggctcc tcagggagcc atttcagctg gagtctcagg tctcaaaaac aacttctcca     5280

ggaggccaaa aaaagactgg gttggcttct ggtcctcatg atggctttta tcctcctggg     5340

acactttggg tatattcatg ggcattgttt ccatctgtct tttctacctg tgccacccct     5400

gccctgattc cacggctgcc tcaggcaggc aggcaaggag ctaggccggt gcccggccct     5460

ggcagcaagg ggtctttgtg cagttggaga tgctgccgtt gtggcagagc gtcctgcagc     5520

cccgcttcca tcagcaggct ctggggtggg ggctttgcag gggatgctct ctgatgtttg     5580

ttccgttgtt taaataaaat gcacttattt ttgttttttt ttttgcaagc                5630


<210> 542
<211> 2791
<212> DNA
<213> Homo sapiens

<400> 542
agtctcgcgg gaagctccgt tgtgggcgcc ccggctggtg gctgagctca ggccttcagg       60

cagaggggag gcgagggcgg ggcggtcacg tgagagcact gccgcggtgg gttgtggggg      120

tgctgcggcg ccgtttgctt tgccaaaccg acaaaagaga gatgatggcc aacgacgcca      180

agcccgacgt gaagaccgtg caggtgctgc gggacacagc caaccgcctg cggatccatt      240

ccatcagggc cacgtgtgcc tctggttctg gccagctcac gtcgtgctgc agtgcagcgg      300

aggtcgtgtc tgtcctcttc ttccacacga tgaagtataa acagacagac ccagaacacc      360

cggacaacga ccggttcatc ctctccaggg gacatgctgc tcctatcctc tatgctgctt      420

gggtggaggt gggtgacatc agtgaatctg acttgctgaa cctgaggaaa cttcacagcg      480

acttggagag acaccctacc ccccgattgc cgtttgttga cgtggcaaca gggtccctag      540

gtcagggatt aggtactgca tgtggaatgg cttatactgg caagtacctt gacaaggcca      600

gctaccgggt gttctgcctt atgggagatg gcgaatcctc agaaggctct gtgtgggagg      660

cttttgcttt tgcctcccac tacaacttgg acaatctcgt ggcggtcttc gacgtgaacc      720

gcttgggaca aagtggccct gcaccccttg agcatggcgc agacatctac cagaattgct      780

gtgaagcctt tggatggaat acttacttag tggatggcca tgatgtggag gccttgtgcc      840

aagcattttg gcaagcaagt caagtgaaga acaagcctac tgctatagtt gccaagacct      900

tcaaaggtcg gggtattcca aatattgagg atgcagaaaa ttggcatgga aagccagtgc      960

caaaagaaag agcagatgca attgtcaaat taattgagag tcagatacag accaatgaga     1020

atctcatacc aaaatcgcct gtggaagact cacctcaaat aagcatcaca gatataaaaa     1080

tgacctcccc acctgcttac aaagttggtg acaagatagc tactcagaaa acatatggtt     1140

tggctctggc taaactgggc cgtgcaaatg aaagagttat tgttctgagt ggtgacacga     1200

tgaactccac cttttctgag atattcagga aagaacaccc tgagcgtttc atagagtgta     1260

ttattgctga acaaaacatg gtaagtgtgg cactaggctg tgctacacgt ggtcgaacca     1320

ttgcttttgc tggtgctttt gctgcctttt ttactagagc attcgatcag ctccgaatgg     1380

gagccatttc tcaagccaat atcaacctta ttggttccca ctgtggggta tccactggag     1440

aagatggagt ctcccagatg gccctggagg atctagccat gttccgaagc attcccaatt     1500

gtactgtttt ctatccaagt gatgccatct cgacagagca tgctatttat ctagccgcca     1560

ataccaaggg aatgtgcttc attcgaacca gccaaccaga aactgcagtt atttataccc     1620

cacaagaaaa ttttgagatt ggccaggcca aggtggtccg ccacggtgtc aatgataaag     1680

tcacagtaat tggagctgga gttactctcc atgaagcctt agaagctgct gaccatcttt     1740

ctcaacaagg tatttctgtc cgtgtcatcg acccatttac cattaaaccc ctggatgccg     1800

ccaccatcat ctccagtgca aaagccacag gcggccgagt tatcacagtg gaggatcact     1860

acagggaagg tggcattgga gaagctgttt gtgcagctgt ctccagggag cctgatatcc     1920

ttgttcatca actggcagtg tcaggagtgc ctcaacgtgg gaaaactagt gaattgctgg     1980

atatgtttgg aatcagtacc agacacatta tagcagccgt aacacttact ttaatgaagt     2040

aaactaggct tatttctaaa aagtcaagtc tattggcttt ggcccaaaag cactggtatc     2100

tttgtattaa attcatgttt attgtcacaa aaccattatt tatacctata cagttgtact     2160

gtttctttta aagcaaagcc atttaacatc tttcttcatt cctaatttgg aaattaaagt     2220

ttacctttct gttaatctat gtataaatgt tactctgagt tattaatgtg gattttaaaa     2280

ttgtaagcaa tagaatagga aataaaacaa ctacctaata caaatatttc tgataagact     2340

acaaatatct gactgagctg gggattaaag tagaggtaac tgtatcttaa atgagtatga     2400

tttccttgta agttaaaaaa attgaaattt aattgtagac ttcaatagtc caagttttga     2460

aggatgtttg agcttttgta taatgccatt tatacctgca gttttacaga taatgtttga     2520

ctgcagttgc cttggaaatt cctccaaagt ttgccttcat ctctcctcta cagtttggag     2580

gtgatggtgc agcagtggaa catctcttga tgcaccacac tacttgtgtt ctgtgaagtg     2640

atgaaagtat aactggttct agtttgcaca ctacacacat agttttgtga agcttcagaa     2700

atgttttttc ttttccttgt ggccaaacca gtttgttaat ctgattatat tcatctgcta     2760

atgatactaa agttaatgta ataaagcatt t                                    2791


<210> 543
<211> 2526
<212> DNA
<213> Homo sapiens

<400> 543
acacctgcca agcatcacac ctgccaagca tcacacctgc caagcatcac acctgcgatg       60

cctgcacgag ctgggtgcgg tccgcgcagc tgcagtaagg gggcgacccg gcgtctgtta      120

gtcggcggtt catctccttc gtgcctcgat gagctttaac gccattttcc tccattctct      180

ttcttcacct cttgagtgag tggccatgag ctgggctgca agagtcctgg ggagcagcca      240

gagagcgggc gccgcgggag cgaattgttt ttgcccaagg atggttctgt gtctccgcca      300

ggcggcatgt gacctgctcg ggcgcgggtg gcccttcacc cctgtgagtg tggccagaag      360

tacctctcac ctggacctgc ggaccccggg cgcagtcctg gagctgagaa ctggaggttg      420

ggggaacagc agggtaaagg ggagagaaaa gggggtcagc tgcgggacgg agtgccgtcc      480

cagctgtagt ttcatgtttg gtggagcaac ccctgttcct ttcctctctc tctctcttaa      540

ttcctcttaa ctgtactcac gcttccttct ccttcccctg gtccgcttca tggatgctga      600

gctgcctggc cagaacctac ccagcttctt tgctggtcag atttgtcggt cttttgtgtg      660

tctgcagcac ctccttccac acgggcccag gagttctcta tacgcgctct caccgcaggt      720

cttggaattc caagccattt ccaattccag gtcttggaaa tggctgtgca atttgtcttc      780

actgttaggt ttccaagatg gcaactatca agagtgaact tattaagaat ttcgcggaag      840

aggaggccat tcatcacaat aagatctcca ttgtaggaac tggatcggtt ggtgtggctt      900

gtgctatcag catcttatta aaaggtttga gtgatgaact tgtccttgtg gatgttgatg      960

aaggcaaact gaagggtgag acaatggatc ttcaacatgg cagccctttt atgaaaatgc     1020

caaatattgt ctccagcaaa gattacctgg tcactgcaaa ctccaatcta gtgattatca     1080

cagcaggtgc acgccagaaa aaaggagaaa cacgccttga tttagtccag cgaaatgtat     1140

ccatctttaa attaatgatt cccaatatta cccagtacag tcctcactgc aaactgctta     1200

ttgttactaa tccagtggat atcttaactt atgtagcctg gaagttgagt ggatttccca     1260

aaaaccgtgt tattggaagt ggttgtaatc tggactctgc tcgttttcgt tactttattg     1320

ggcaaaggct tggcatccac tctgaaagct gtcatgggct gatccttgga gagcatggcg     1380

actcaagtgt tcctgtgtgg agtggtgtga acattgctgg cgtccctctg aaggatctga     1440

acccagatat aggaactgat aaagatcctg agcagtggga aaatgtccac aaaaaagtga     1500

tttccagtgg ctatgagatg gtcaaaatga aaggttatac ttcttggggc attagcctat     1560

ctgtagctga tttaacagaa agtattttga agaatcttag gagagtgcat ccagtttcta     1620

ccctaagtaa gggcctctat ggaataaatg aagacatatt ccttagtgtc ccatgtatcc     1680

tgggagagaa tggtatcaca gacctcataa aagtaaaact gactcttgaa gaggaggcct     1740

gcttgcaaaa gagtgcagaa acactttggg aaattcagaa ggagctcaag ctttaaagtt     1800

gcttaaagct aattctgtag attgaagatg aaatagtagt tatggaattg tatatgtcaa     1860

acttttgaat aaatttgaat ttctaaaagt tggaaaaata gaggaaagag tgacctattt     1920

agtatagcct tccagctttt ttttttttct tttttgggag ggtctcattc tgtcacccag     1980

gctggagtgc agtggcacaa tcatggctca ctgcaacctt gacctcccga gctcaggtga     2040

gcctcccact tcagcctcca gagtaggtgg gaccacatgc gtgtgcctcc atgcctgcct     2100

aatttttgta tctttttgta gagatggggt tttgccatgt catccaagct ggttttgaac     2160

tcccaaagtg ctgagattac aggggtgagc cactgtgcct ggccttagct ttgatttagt     2220

atccagatga tagatgacac tttttttttt ttttttttaa agtgacggca tcaaagatgt     2280

ttttggtact tctcagtact tgccttgtat gtatacgtaa ttgccatctg gtccacaaga     2340

atgtgtttac tgtgttacac aaatcctgat tcttttcatc aggtgcatag taattcttct     2400

ctatggctta atacctatgt tcatttacat gctatctcta caatgtaaaa ataaaagtgt     2460

atatatatac acacacacac agagagtaat ctaaatgttc ctaacactag ataaaacatt     2520

gatttg                                                                2526


<210> 544
<211> 2226
<212> DNA
<213> Homo sapiens

<400> 544
gcaaatagac ccaggcttga ctggcaatta aacatgaaac ttctcattgg gtattttcga       60

gactactacg gggaatcagc taccagctta ctgccatgtg gagaactgca cgagattccg      120

ggattggaat caaaatgcta atttaaaagg tcaagtgaag ctgctcctca cgttttggcg      180

tgcctgcgct ctctgcaggc agaagcgaac aaagacccag caagagaagg cagaggctaa      240

gacccatccc gtatctgctc tcctgaaata attctggagt catgcctgaa atgccagagg      300

acatggagca ggaggaagtt aacatcccta ataggagggt tctggttact ggtgccactg      360

ggcttcttgg cagagctgta cacaaagaat ttcagcagaa taattggcat gcagttggct      420

gtggtttcag aagagcaaga ccaaaatttg aacaggttaa tctgttggat tctaatgcag      480

ttcatcacat cattcatgat tttcagcccc atgttatagt acattgtgca gcagagagaa      540

gaccagatgt tgtagaaaat cagccagatg ctgcctctca acttaatgtg gatgcttctg      600

ggaatttagc aaaggaagca gctgctgttg gagcatttct catctacatt agctcagatt      660

atgtatttga tggaacaaat ccaccttaca gagaggaaga cataccagct cccctaaatt      720

tgtatggcaa aacaaaatta gatggagaaa aggctgtcct ggagaacaat ctaggagctg      780

ctgttttgag gattcctatt ctgtatgggg aagttgaaaa gctcgaagaa agtgctgtga      840

ctgttatgtt tgataaagtg cagttcagca acaagtcagc aaacatggat cactggcagc      900

agaggttccc cacacatgtc aaagatgtgg ccactgtgtg ccggcagcta gcagagaaga      960

gaatgctgga tccatcaatt aagggaacct ttcactggtc tggcaatgaa cagatgacta     1020

agtatgaaat ggcatgtgca attgcagatg ccttcaacct ccccagcagt cacttaagac     1080

ctattactga cagccctgtc ctaggagcac aacgtccgag aaatgctcag cttgactgct     1140

ccaaattgga gaccttgggc attggccaac gaacaccatt tcgaattgga atcaaagaat     1200

cactttggcc tttcctcatt gacaagagat ggagacaaac ggtctttcat tagtttattt     1260

gtgttgggtt cttttttttt tttaaatgaa aagtatagta tgtggcactt tttaaagaac     1320

aaaggaaata gttttgtatg agtactttaa ttgtgactct taggatcttt caggtaaatg     1380

atgctcttgc actagtgaaa ttgtctaaag aaactaaagg gcagtcatgc cctgtttgca     1440

gtaatttttc tttttatcat tttgtttgtc ctggctaaac ttggagtttg agtatagtaa     1500

attatgatcc ttaaatattt gagagtcagg atgaagcaga tctgctgtag acttttcaga     1560

tgaaattgtt cattctcgta acctccatat tttcaggatt tttgaagctg ttgacctttt     1620

catgttgatt attttaaatt gtgtgaaata gtataaaaat cattggtgtt cattatttgc     1680

tttgcctgag ctcagatcaa aatgtttgaa gaaaggaact ttatttttgc aagttacgta     1740

cagtttttat gcttgagata tttcaacatg ttatgtatat tggaacttct acagcttgat     1800

gcctcctgct tttatagcag tttatgggga gcacttgaaa gagcgtgtgt acatgtattt     1860

tttttctagg caaacattga atgcaaacgt gtattttttt aatataaata tataactgtc     1920

cttttcatcc catgttgccg ctaagtgata tttcatatgt gtggttatac tcataataat     1980

gggccttgta agtcttttca ccattcatga ataataataa atatgtactg ctggcatgta     2040

atgcttagtt ttcttgtatt tacttctttt tttaaatgta aggaccaaac ttctaaacta     2100

attgttcttt tgttgcttta atttttaaaa attacattct tctgatgtaa catgtgatac     2160

atacaaaaga atatagttta atatgtattg aaataaaaca caataaaatt aacacttgat     2220

ccagaa                                                                2226


<210> 545
<211> 4461
<212> DNA
<213> Homo sapiens

<400> 545
gtggtttggg gaaagtgtag gggcaaccaa agatcatcgg cttgactagg ccctttgccc       60

tgaacctcat gaagaaatga taggaggcag acatatgtgc ctaaaaagag cgttgagctc      120

agagaagagc aactcggagt tttgggggtg tgctttgatt tgtgtacatc aatggcagaa      180

tcatccagcg aatcagatca cttccgctgt cgtgaccgat tgagtccatg ggctgccaga      240

tcaacgcaca ggggaactcg aagtcttcct acagtagaag ttaccgagaa ggtcaacact      300

ataacaagta ctttacagga taccagtcgg aacctgcgac aagtggacca gatgcttgga      360

cgataccgag aatacagtaa tggacaggcg ggtgcgatag aacatttaaa agaaagcttg      420

gaacaatcaa tcgaccaact ccggagtcaa cgtttattga gaaactcagg agggagaagt      480

atttctgtta caagtttgag tgcaagtgac cttgatggtg gcactgggtc agagctccat      540

cattttccac ctacctcacc tctcaaggac tatggggatc cacagggtat taaacgaatg      600

agatcaagaa ctggtgtccg gtttgttcaa gagactgatg atatgactca gcttcatggt      660

tttcatcagt ctcttcgaga cctcagcagt gaacaaattc gccttggaga tgatttcaac      720

agggagcttt ccagaaggag ccggtcagat gccgaaacaa aaagggcttt ggaagaattg      780

actgaaaaac ttaatgaagc ccagaaacaa gaagtggttt cagatcgggt ggagcggcgg      840

cttcaggaac tggagagaga gatgcgcaca gaaagggagc tggtggaaag acgccaggat      900

caactgggac tcatgtccct gcagctacag gaggcactaa agaaacaaga agctaaagca      960

gatgagcatg agggggcaat aaaaaataag ctaagacaaa ctgaaactga gaagaatcaa     1020

cttgaacagg aattggagct atctcgaagg ttattgaatc aatcagaagg cagccgagaa     1080

acacttttgc atcaggtaga agaactgcgt acacaactta cgaaagcaga aggtgatcga     1140

aagggtttac agcatcaagt atctcagatt tccaagcaac agtcaaacta tcaggatgaa     1200

caaggggagg actggagatt taggagaggg gttgagcggg aaaaacagga cctggagaag     1260

caaatgtcag atttgagagt gcagctgaac ttcagcgcaa tggcatctga gttagaggaa     1320

gtgaaacggt gcatggagag aaaagacaag gagaaagcac atttggcatc acaagtagag     1380

aatttaacac gtgaactgga gaatggggaa aaacagcaac tgcagatgtt ggatcgactt     1440

aaggagatcc agaatcactt tgacacatgt gaggccgagc gtaagcatgc tgaccttcag     1500

atctcagagc tgactcgcca tgcggaggat gcaaccaagc aggctgagcg gtacctcagt     1560

gagctccagc agtcagaggc tctgaaagag gaggcggaga agaggaggga agacctgaaa     1620

ctgaaagctc aagaatccat taggcagtgg aagcttaagc ataagaagtt agaacgagcg     1680

ttggagaaac aatctgaaac tgttgatgaa ctgacaggca agaataatca gattttaaaa     1740

gaaaaggatg aattgaaaac ccagctgtat gcagcattac aacaaataga gaatcttcga     1800

aaggaattga atgatgtcct aacaaagcgt gcccttcagg aggaggagct tcactccaag     1860

gaggagaaat tacgtgatat taagtctcat caagctgacc ttgaattgga agttaagaat     1920

tccctggata ccatccatag actggagagc gaattgaaaa agcagagtaa gatccaaagc     1980

cagatgaaag ttgagaaagc tcacttggag gaagaaattg cagagctcaa gaagagccag     2040

gcccaggaca aagctaaact tcttgagatg caagagtcca tcaaggacct gagtgccatc     2100

cgagcagatc ttgctaataa attggctgag gaagagagag ccaagaaagc agtgcttaag     2160

gacctttctg acctcactgc acaggcaaaa tccagggatg aagaaacagc tacaatcatc     2220

acacagttaa agctggaacg agatgtgcac cagagggagc tgaaagatct cacatcatca     2280

ttgcagagtg tgaaaacaaa acacgaacag aatatccagg agcttatgaa gcactttaag     2340

aaagaaaaga gtgaggctga gaatcatatc aggactctga aggctgaaag tttagaagag     2400

aagaatatgg ctaaaattca tcgtggtcag ctggagaagt tgaaatcaca gtgtgacaga     2460

ctgacagagg aattaaccca gaatgaaaat gagaacaaaa aactgaagct aaaatatcaa     2520

tgtttgaagg atcaactaga agaaagggaa aaacatataa gcattgaaga ggagcactta     2580

aggaggatgg aagaggccag attgcagctc aaggatcaac ttctttgctt ggagactgaa     2640

caggaatcca ttcttggtgt gataggaaag gaaattgatg cagcttgtaa aacattctcc     2700

aaggactcag tggagaaatt aaaagttttt tcatctggtc ctgatataca ttatgaccca     2760

catcgctggt tagcagaaag caagactaaa cttcagtggc tctgtgagga actgaaagag     2820

agagaaaaca gagagaaaaa tctgcgacac cagctgatgc tctgcagaca acaactcagg     2880

aatttgactg aaaacaagga atctgagttg cagtgtctct ttcaacagat agaaaggcag     2940

gagcagcttc tggatgaaat acatcgtgag aagagagatc tactggaaga gacccaaaga     3000

aaagatgaag aaatgggatc tctgcaggac cgtgtaattg cattagaaac gagtacccaa     3060

gtggccttgg accatctgga gtctgtgcct gagaaactga gcctactaga agatttcaaa     3120

gacttcagag attcctgcag ttcatctgag agaactgatg gaagatattc caaatacagg     3180

gttcgcagaa attctcttca gcatcaccaa gatgacacca agtacagaac caaaagtttc     3240

aaaggtgaca gaacctttct ggaaggttcc cacactcgtg ggttagatca ctcatcctct     3300

tggcaggatc acagtcgctt cctgtctagt ccaagatttt catacgtgaa ctcatttacc     3360

aaaagaactg ttgctccaga ttcagcttca aacaaggaag atgccacaat gaatggaaca     3420

agttcacaac ccaaaaaaga ggaatatggg agctaaaaaa gcaaatgtaa tttgttattt     3480

tacatgagta tgttacaaat aataacatct ctattcttac agcaatttgg cccagattat     3540

ctaacagaca tacctgcagc tttggctctt tggtattgcc aaacattgac aaaagtgaca     3600

atactgttgg tccttgtgaa tggtaaacca atccaaataa tatcagatca tgaatgatgt     3660

gcagctaatt tatttgcaac ttatactagc acagaaagaa tgatattttt tcactttgta     3720

ttttcctttt tcaagtgtgg tcagtcacat tttcccaacc aaaatttgga tttctaattg     3780

aggcctttta aaaattactg gctaaaaaga aggaaaatga gtttcccttg aggcaaaagt     3840

tgccagcact ttagattcag ggagcattta tatacaactg attttttgaa aaattttctc     3900

cctaataaat tatcatgtgt tataacatgt ggagatgtgc atatataaca ttagacagtc     3960

cactttataa atgctcagga cttttatatc tatcatctta acagtccaca actgcatacc     4020

gtagctgaaa attatttcca atcatccatt tttaatagca ataaagaatt cataaatgat     4080

atctgaactg tagagcactg taaagaattc atagcacaat ttatttattt gtctttttgt     4140

ggccaaatat cctactgtga tcacttcagt catatcctgg accgtctttg gtttactgtg     4200

actaaaatca tagcaccaaa ctcctttgtc catgagattt atatataatc ttgtataatt     4260

tggtcctatc tgcttctacc atcccaactt ttttcatcaa agtgtctaag aacgtattcc     4320

ctttacacgc tgatctccta gtggagaagg atttatatta aatgctaagt aatagtaaac     4380

tttcaggaac tgaatcctat tgggtcatgg attctgcata gacaagggca ataaagcaat     4440

acctttgtaa tatgcattac a                                               4461


<210> 546
<211> 1542
<212> DNA
<213> Homo sapiens

<400> 546
tgcgtttagg gcgaagacgg agttgtaaac ttcttaaaat tcctctctcg acacttcggt       60

aattcctctt tcgagactaa agctcttttt gtatgcgtgt gtgtcaagcg tatgccccgg      120

gattctcctc cgcttccttt tctcggtctt ccttcttgct ttagggaccg gaagagtcct      180

tgaaccaaaa tagctcggcg ggcacttccg gggccggcgc ccagagttcc gggagggtgc      240

aggcaggaga gggaaaggca gcagcggcgg cagctggagg atgaagaagg agcatgtgct      300

tcactgccag ttctccgcgt ggtacccgtt cttccgaggc gttaccatca agagtgtcat      360

tcttccactt cctcagaatg tgaaggatta tttactcgat gatggaactc tggtggtttc      420

aggaagggat gatccaccaa cacattctca gccagacagt gatgatgaag cagaagaaat      480

acagtggtct gatgatgaga acacagccac gcttacggca ccagaatttc ctgagtttgc      540

cactaaagtc caggaagcta tcaattccct cgggggcagt gtctttccta agcttaattg      600

gagtgcccca agggatgcgt attggatagc aatgaatagt tctctgaaat gtaaaaccct      660

cagcgacatc tttctgcttt tcaagagttc cgatttcatc actcgtgact tcactcagcc      720

gtttattcat tgtactgatg attctccaga tccatgtata gaatatgagc tcgttctccg      780

aaaatggtgt gaattgattc ctggggctga gtttcgatgt tttgtcaagg aaaacaagct      840

tattggtatt tctcaaagag actacacaca atactatgat catatttcta aacaaaagga      900

agaaattcgc agatgcatac aagacttttt caagaaacac atacagtaca aattcttaga      960

tgaagacttt gtgttcgata tatacagaga cagtaggggg aaggtgtggc tcattgactt     1020

taatccattt ggtgaagtca cagattcact gctgttcacc tgggaagaac tgatatctga     1080

gaacaactta aacggcgatt ttagtgaagt tgacgctcaa gagcaggatt ccccagcttt     1140

ccgttgcaca aacagtgaag tgacagtcca gcccagcccc tatttgagtt accggctacc     1200

caaggacttt gtagacctct ctactgggga ggacgctcac aagctaatag acttccttaa     1260

gctgaagaga aatcagcagg aggacgactg atgagcgtac tggaactgga gaagaggagg     1320

ccccgcccca ccgctccggg agctgctcat cagccgcaac ttcctgccga ccctgatgcg     1380

ggtgggccga gcagtgtgga catcagccac tttttatatt catgtacatt cacctgggga     1440

aaaaaacgga gggactttgc tacttgtaaa aataacataa taaatagatc ttaaacatag     1500

gaaaaccata ctgttctgat aataaaatgc tttctatgaa at                        1542


<210> 547
<211> 4023
<212> DNA
<213> Homo sapiens

<400> 547
agtactccct gattggctct gcactggagg cagtgatttt ggggcagaga attttgcaac       60

acgtggtagt gaactgtgag gagtttgagg ggtctgaaga ctgaaagagt cgaatggttt      120

gttggcaggg tgtcctggtg gattggtttc tgtaagttca gattctcata aatcgtgtga      180

gcgtcgccga cacctctgag ataaaagggc ccctttcgac tagcctctgc tgaaaggacc      240

tagaagaatc ccttaggatg aagctgagtc ttaccaaggt agttaatggc tgtcgcctag      300

gaaaaataaa aaacctgggc aaaacagggg accacaccat ggatattcca ggctgccttc      360

tgtataccaa gactggctcc gccccacacc tcacccatca cacgctgcat aatatccacg      420

gggttcctgc catggctcag cttacgctgt catccctagc agaacatcat gaagtcttga      480

cagaatataa agaaggagtt ggaaagttta taggcatgcc agaatcactc ttgtactgct      540

ccctgcacga tccagtcagc ccctgcccgg ctggttatgt aacaaacaag tctgtgtctg      600

tgtggagtgt tgcaggacga gtggaaatga ctgtttccaa gttcatggca attcagaagg      660

cccttcagcc agactggttc cagtgcctct ccgatggaga agtatcttgt aaggaagcaa      720

cttccataaa aagggtcaga aagtctgttg accgatcact tcttttcttg gataactgtc      780

tgcggctgca ggaagagtca gaggttcttc agaagagtgt gatcattgga gtgattgaag      840

gtggagatgt gatggaagag aggctgaggt cagcacgaga gacagccaag cggcctgtgg      900

gtggcttcct tctggatggt tttcaaggaa atccaacaac cctggaggct agactacgct      960

tgctgtcatc agtcactgca gagctgccgg aggacaagcc aaggctcata tctggtgtta     1020

gtcggccaga tgaggtgctc gagtgtattg aaagaggagt ggacttattt gagagttttt     1080

tcccttatca agtaacagag cggggatgtg ccctgacttt cagttttgat taccagccga     1140

atcctgaaga gacactacta caacaaaatg gaacacaaga agaaataaaa tgtatggatc     1200

aaataaagaa aattgaaaca actggttgca accaagaaat aacatcattt gaaattaatc     1260

tgaaggaaaa aaagtaccag gaggacttta acccgctggt gagaggatgt tcctgttact     1320

gctgtaagaa tcacactcgg gcatacatcc accatctgct ggtgaccaat gagctgctgg     1380

ccggagtcct gcttatgatg cacaactttg aacactactt tgggtttttc cattacatcc     1440

gggaagcact aaaaagtgac aaactggcac agttgaaaga gctcatccac aggcaagcat     1500

cttgagatct tgcaaataca agtctcactc ttcacactga gcctgtacca ctgttgtaac     1560

atgggaagac gtgaagaaga aataatctga gctttaatta tttatatttg gatataaggt     1620

ctgcttaaat aaagaatctt tgtaccaaac tgcccacatg agggtgaaga gatttcctca     1680

aaagacttaa atgacctgga ttgatcagag agaattgaac tgtgaccttt aagacttcta     1740

gactaattct tttagttgat agagattcat ttagtcaaag acaaaagctt taactgtgag     1800

ggcacagcct tgaagtggga gtgatgagat tctgagggac ccatgaattg gattgaggct     1860

tgaggggaaa tggtgtgaga cgaatgggct ctggacatat gcctgttgat ttgagaagaa     1920

atctggctgg tttgagggtt tcctttagtt caccctcata ctctcaggag actcttctgg     1980

atacttttgt cttccaccct gccctggcag tgcagccaat cagaaatggc tcttgtgact     2040

taactgggct tggatatccc tggaatgtgg ggcttgaaca ttgctcctgt gatgatcatc     2100

tgtcccaggt cacactcctt catttgacca catggcctat ttgcaacttc tttttagagc     2160

caatgtaatt gcctgttagg agccagaagt ttgcccagct gctttcttct ggttgtacag     2220

atccattgtg gtctgccttc caggctcatt aatagtctaa ctacgtaata actgaagacc     2280

tatctcttgt gaagattcat tctcaatgtg ttcacttgga cagagccctg cctggcctaa     2340

cgattagagg gttagtctcc atcctgctca gatatgactc ctgggcaatt cacttaactt     2400

ctccatggct gcttcctgct gaataaatag ggacaggcat aatggatagg aatgaatgaa     2460

cttttaagat actgtctagc tctaaaattg gaagaacaaa aagttttaga ttagagtcat     2520

agccttaata gccctagttg tcatcctggg agacaggcaa cagtagagat atttgagagc     2580

ctaaagagag gtttggcctg tgggttttta agtggttatt gaattggtat caggagatcc     2640

tgaggctggt aggggaaggt aattctttct aagttacctc tgtatttttc aagttttcta     2700

taaggaatac acatacaccc acatgcacac accatagttt ttatacaaac agcaataaca     2760

aaaccaaaaa gatgcccctt tttttgtagg gataagaaat acatttgttt tatacttcta     2820

tgctatattt tgctattcaa aatttagtgg gcattactta acattgtttc taattatttt     2880

gtggctgctg tatgttttat gtgttgggag cccattgtat taggccgttc ttggattgct     2940

ataaagaaat acctgagact gggtaatttg gttttttggt tttttggggt tttttttgag     3000

acggagcctt gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctctatgcaa     3060

cctccacctc ctgggttcat gccattctcc tgcctcagcc tcccgagtag ctgggactac     3120

aggcgcccgc caccatgcct ggctaatttt ttatattttt agtagagatg gggtttcacc     3180

gtatgagcca ggatggtctc gatctcctga cctcatgatc cacaagactg ggtaatctgt     3240

aaagaaaaga ggtttaattg gctcatggct ctgcaggctt tacaggaagc atggtactgg     3300

catctgcttg gtttctgggg aggcctccgg aagcttatag tcatgacaga aggtgaaggg     3360

ggagcaggca catcacatga caaaagcagg aacaagactc agagcaagaa gtcacttatc     3420

accaagggga tggcccaggc cattcatgag ggatccacct ttgtgctcca aacacctccc     3480

accaggcccc acctccagta ttggggatta catttcaact tgaggtttgg gcgggaacaa     3540

atagtcaaat tatattaccc atctacatgg ttttcttttt cttagtatgg gagtgtccat     3600

gaataaattc atgggcatcc tcataactct tccatgaatg gcaaggggta cttatggaaa     3660

acagttttcc aaagatctga ttgttttgaa atgtgttaga ttggacttgt tcaaatgttc     3720

atatttttgt tctatgctaa atgcatcgtt aggggagtag tggtaaatat tccagaatcc     3780

atatgaaatt catgagttta tttatgtcta aaacactgaa aactgtgtcc aatatcgttc     3840

agtttcctgg gtctttttct tattagcaca tttgagaaaa atattccttt cctttattgt     3900

agtaaatcta ttaaaggcaa tagccaataa aacattttta attttaaaaa tttactgtgt     3960

ttggctttct gtaaatgtag taggtctgtt aaacaaaata ttaaatttcc atagtaccag     4020

aaa                                                                   4023


<210> 548
<211> 3369
<212> DNA
<213> Homo sapiens

<400> 548
acattacaat gcctgacaaa tcctagccag ttctatcaaa ttatatcttt cttacaggct       60

tttaagctat tagtctcata aagatacatt taatcagcga ggtaatggca tgatgagtgt      120

ttttaggtta aaaagagaac aggaactgtt gccagcagaa tggcgatatt caagacaaca      180

cgcacaagaa gaggcgggtc ctacgcgctt cgctagggaa gcccgggtca gctcgctgcg      240

caggcgcagt gagttcgaca caccatgccg actgtcagcg tgaagcgtga tctgctcttc      300

caagccctgg gccgcaccta cactgacgaa gaatttgatg aactatgttt tgaatttggt      360

ctggagcttg atgaaattac atctgagaag gaaataataa gtaaagaaca aggtaatgta      420

aaggcagcag gagcctctga tgttgttctt tacaaaattg acgtccctgc caatagatat      480

gatctcctgt gtctggaagg attggttcga ggacttcagg tcttcaaaga aaggataaag      540

gctccagtgt ataaacgggt aatgcctgat ggaaaaatcc agaaattgat tatcacagaa      600

gagacagcta agatacgtcc ttttgcggta gcagcagttc tccgtaatat aaagtttact      660

aaagatcgat atgacagctt cattgaactt caggagaaat tacatcagaa tatttgcagg      720

aaaagagcac tggttgccat tggtacccat gatttggaca ctttgtcggg cccatttact      780

tatactgcaa agcgtccttc agatatcaaa ttcaagcctc taaataagac caaggagtat      840

acagcctgtg aactgatgaa catatacaag actgacaatc acctgaaaca ttatttacat      900

atcattgaaa acaaacccct gtatccagtt atctatgata gcaatggtgt cgtcctttca      960

atgcctccca tcatcaatgg ggatcattcc agaataacag taaatactag aaatattttt     1020

attgaatgca cgggaactga ctttactaag gcaaaaatag ttcttgatat tattgtcacc     1080

atgttcagtg aatattgtga gaatcaattt acggtcgaag ctgctgaagt ggtttttcct     1140

aatggaaaat cacatacctt tccagaatta gcttaccgaa aggagatggt gagagctgac     1200

ctaattaaca aaaaagttgg aatcagagaa actccagaaa atcttgccaa acttctgacc     1260

aggatgtatt taaaatcaga agtcataggt gatgggaatc agattgagat tgaaatccct     1320

ccaaccagag ctgacattat ccatgcatgt gatattgtag aagatgcagc tattgcttat     1380

ggatataaca acattcagat gactctcccg aaaacttaca ccatagctaa tcaatttcct     1440

cttaataagc tcactgaact tctccgacat gacatggcag ccgctggctt cactgaagca     1500

cttacctttg ccctgtgctc ccaagaagat attgctgata aactaggtgt ggatatctct     1560

gcaacaaagg cagtccacat aagtaatcct aaaacagctg aatttcaggt ggcacgcact     1620

acccttcttc ctggcctcct gaagaccata gcagcaaatc gtaagatgcc ccttccactg     1680

aaactgtttg aaatctctga cattgtaata aaagattcta atacagatgt aggtgcaaaa     1740

aactacagac atctctgtgc tgtttattac aacaagaatc ctgggtttga gatcattcat     1800

gggctgctgg acagaattat gcagttgctc gatgtgcctc ctggtgaaga caagggggga     1860

tatgtgatca aagcatcaga agggcctgct ttcttccccg ggcgatgtgc agagatcttt     1920

gccaggggtc aaagcgtcgg gaagcttggg gtccttcatc ctgacgttat caccaaattt     1980

gagctgacca tgccctgctc ctccctagaa atcaatgttg gacccttttt gtgaagattg     2040

gtctctgtgg tgtgattctc ttcccaggtg tccctttctc ctcccctagt gtccttaagt     2100

cctcctccac agggaacatc tatttgggct ttgatgttta ataaagtaga aagcactgtc     2160

tggctgtgtg ggtagagacc atcctttccc tgcatattag gccagcttgt gccatatacc     2220

agtgtggtgt ctgtgtgtga agctgcattg ttgggtaaaa gccccgtgga gtgctggaga     2280

aatgcactag cagagtgcag gatctgttct gaaaggcaga cgtgctcctc agacatcaga     2340

acatcacatt ggaacggatt actcctgcat aacaagatcc catttctttc cttattgata     2400

aaacaagata atcgatgaga attcatgttg catgagttcg agataactga ggggtttagc     2460

tttgattttc tacatttgac atgtattcat cattgagaaa cactaaaata acaatatttt     2520

tagaaaacgt ttaagaatca attatggtcc aacaattata gcttctgagg tcagtttaaa     2580

gtgaaagaaa aatctgtaat acaaggattc aaaatatgtg agggtgcata ggtatttttt     2640

actctatctg tgatactcta agatagagta catgcaacaa agatctgttc tgctgtaaga     2700

gttaaaatgg acaagtattg atatcaatgc agtatgaaca ttaggaaaca atgagaagct     2760

tatttttgcc ataggccata catgttactg taatcagtca gttataaaat catggtttta     2820

aatacttaat tgagctacta gtttctctat tgtcccaggg agatattaga cctctctttt     2880

tctgaagcta agcttcagcc aatcctcctt gttttatatc ctaatttcct ttcttacttc     2940

aatctagaat tctccagtag gtaccatctc tggaaaaaag ctgggtctca tgtttgagac     3000

aagttcccag gtactattga agtaataaga aatatgataa aatataatac tttaaagtcc     3060

cagtagaaat agctaacaaa ggctgggtgc gctgtggctc atgcctgtaa tcctagcact     3120

ttgggaggct gaggtgggca gatcacttga ggccaatagt tcgagatcag cctgaccaac     3180

atggtgaaat gccatctcca ctaaaaatat aaaaattagc caggcatggt ggtgtgggcc     3240

tgcagtccca gctacctggg aggctgagtc aggaaaatct cttgaaccag gaggtggacg     3300

ttgcagtgat cccagattgt gccactgccc tccagcctgg gtgacagagt gagattctgt     3360

ctacaaaaa                                                             3369


<210> 549
<211> 933
<212> DNA
<213> Homo sapiens

<400> 549
tttcttgaaa gaggcattta ccgagcgccc aatgtatgcc tggcactggg ctgggtgctg       60

ccacctaagc gagcacgacc aatgcagtct atcagggagg cccagatcgc caagcagcgg      120

acccctgcgg tccgccatgc cactcccggc tcctagagcg ccgctcagca caccgtgagc      180

gcccaataac tgttgggctt caatgacgcc gcggaggcgg ccccgtcccc gcgctcccgc      240

ccctcccgcc agggcagccc gggaggccag acgttgacgc tgcagggaga gggtggtggg      300

cgcagccgct agggggcgcg gcggggcgga gcgcaccttt ccgcgggccg cggggatggc      360

ggcgcagggc gtagggcctg ggccggggtc ggcggcgccc ccggggctgg aggcggcccg      420

gcagaagctg gcgctgcggc ggaagaaggt gctgagcacc gaggagatgg agctgtacga      480

gctggcgcag gcggcgggcg gcgctatcga ccccgacgtg ttcaagatcc tggtggacct      540

gctgaagctg aacgtggccc ccctcgccgt cttccagatg ctcaagtcca tgtgtgccgg      600

gcagaggcta gcgagcgagc cccaggaccc tgcggccgtg tctctgccca cgtcgagcgt      660

gcccgagacc cgagggagaa acaaaggcag cgctgccctc gggggagcat tggccctggc      720

ggaacgcagc agccgcgaag gatccagcca gaggatgcca cgccagccca gcgctaccag      780

gctgcccaag gggggcgggc ctgggaagag ccctacacgg ggcagcacct aggatggggc      840

agagacttgt tgcatctttg tccccagcaa aggctacatg ttacctcctt caattgataa      900

taaacctttc tgagatgcag agggtccagg tca                                   933


<210> 550
<211> 1354
<212> DNA
<213> Homo sapiens

<400> 550
aagtgcacta ggtttgaaat cggaaagttg gcggggctgc gggagctgag cctagagtcc       60

ggctgttggc tagagtgggc gcggatctgg tgtggggaag gcggcgggac tcaggcctgc      120

ctgcgaagca ttgtcctaca taatggtaga ggacgaactg gcacttttcg ataaaagcat      180

aaatgaattt tggaataaat tcaaaagtac ggacacctcc tgtcagatgg cgggactaag      240

agatacctac aaggattcca tcaaagcatt tgcagaaaag ctgtctgtga aattaaagga      300

agaagaacga atggttgaga tgtttctgga atatcaaaat cagatcagca ggcaaaataa      360

gctcattcaa gaaaaaaagg ataacttgtt aaaattgatt gctgaagtaa aaggcaaaaa      420

gcaggaattg gaagtactga ctgcaaatat ccaggatctt aaggaagaat attctaggaa      480

gaaggaaact atttctactg ctaataaagc gaatgcagag aggttgaaaa ggctgcagaa      540

atctgcagac ttgtataaag atcgacttgg actagaaatt cgaaaaattt atggtgagaa      600

attgcagttt attttcacta atattgaccc taagaatcct gagagcccat ttatgttttc      660

cttacatctc aatgaagcaa gggactatga agtgtcagat agtgcccctc atcttgaggg      720

cctagcagaa tttcaagaga atgtaaggaa gaccaacaat ttttcagctt ttcttgccaa      780

tgttcggaaa gcttttactg ccacggttta taattaacat acaaatagtg tatataaaaa      840

cggtttattt ttcttctcta ttacatatct ctttttttct tgtttttatt attattatac      900

tttaagtttt agggtacatg tgcacaatgt gcaggtttgt tacatatgta tacatgtgcc      960

atattggtgt gctgcaccca ttaactcgtc atttcattag gtatatctcc taatgctatc     1020

cctcccccct cccccaaccc acaacagtcc ccgttgtgtg atgttcccct tcctgtgtcc     1080

atgtgttctc attgttcaat tcccacctag gagtgagaat atgtggtgtt tggttttttg     1140

tcctttcgat agtttgctga gaatgatggt ttccagcttc atccatgttc ctacaaagga     1200

catgaactca tcctttttta tggctgcata gtattccatg gtgtatatgt gccacatttt     1260

cttaatccag tctatcattg ttggacattt gggttggttc caagtctttg ctattgtgaa     1320

tagtgccgaa ataaacatac gtgtgcatgt gtct                                 1354


<210> 551
<211> 4544
<212> DNA
<213> Homo sapiens

<400> 551
atgaaactga ctgattcgac taaaggatgg atagtttggg cagcgttgga cagctctatg       60

aggggaatgt cgttgtctgc tgggtcttcc cctcttcatt cccccaagat tactccacat      120

acttctcctg ctcccagaag aagaagtcac actccaaatc cagcaagtta catggtgcct      180

tctagtgcct ctacatctgt taataatcct gtttctcaga ctccgtcttc tggtcaggtg      240

atccaaaagg aaactgttgg tgggacgact tacttctata cagacacaac tccagcacct      300

ttgactggaa tggtgtttcc aaactatcat atttatcctc caactgcacc tcacgttgct      360

tatatgcaac cgaaagcaaa cgcaccttcc ttcttcatgg ctgatgaact ccgacaggag      420

ctgatcaaca gacatttaat aacaatggct caaattgatc aagcagatat gccagcagtt      480

cctacagagg ttgacagcta ccatagccta ttccctctag aaccactgcc acctcccaac      540

cggatacaga aatcaagtaa ttttggatat attacatctt gctacaaagc tgtaaacagc      600

aaagatgatc tgccatattg ccttcggagg atacatggtt ttcgtcttgt taacacaaag      660

tgcatggtgt tggtcgacat gtggaagaaa attcaacact caaatatcgt aactttgcgt      720

gaagtattta ccactaaagc atttgctgag ccctctcttg tgtttgcata tgatttccat      780

gctggaggag aaactatgat gagcagacac tttaatgacc ctaatgctga tgcctacttc      840

accaagagaa agtggggtca gcacgaggga ccattgccca ggcagcatgc tggattattg      900

ccagaatctc ttatttgggc atatattgtc caactaagtt ctgcattgcg taccattcat      960

acagcaggtt tggcatgtcg agttatggat ccaacaaaga ttctgataac tggcaaaaca     1020

aggttgcgag taaattgtgt tggagttttt gatgttttaa catttgataa cagtcaaaat     1080

aataatccat tggcattaat ggcccagtac cagcaagcag atctgatatc attaggaaaa     1140

gttgtgttgg ctttggcttg caactctttg gcaggaattc agcgagagaa tttacagaaa     1200

gccatggaac tggtgacaat caactattcc tctgacctga agaatctgat tttgtatttg     1260

ttgactgacc aaaacaggat gcgaagtgta aatgacatca tgcccatgat tggtgctcga     1320

ttttatactc aattggatgc tgctcaaatg agaaatgatg tcatagagga agaccttgca     1380

aaggaggttc aaaatggaag actgtttagg ctcctagcaa aattgggaac aatcaatgag     1440

aggccggagt ttcagaagga tcccacttgg tcagagactg gagaccgtta tctgttgaaa     1500

ctctttaggg atcatctttt tcatcaggtg acagaagcag gtgctccctg gattgacctc     1560

agtcatataa tttcttgtct taacaagcta gatgctggtg tgccagaaaa aataagcctg     1620

atttccagag atgagaagag tgtacttgtg gtgacctaca gtgacttaaa gcgctgcttt     1680

gaaaatactt ttcaagaact gattgcagct gcaaatggtc agttgtagta tttgctaaaa     1740

aagcacgcag gacatggcta aagaccttaa ccaatagcaa attgcactac agctgaactt     1800

ttcatcatct cattcacatt tgggaaacga acaggagatg agcaaagctg cttgcacttc     1860

agtcaggtac actgttactt gaaaggaaga atgtttcact tacccaagag ctatggctgc     1920

cattggaggc tgttatctgt gaagaattta ttttagattt aggagcacca tcaggtgaat     1980

gatgttcctg cttttgtttt ttccacttgt atatgcacta attttaattt tttaaagact     2040

ttttctgatc tttgaacttt tgccacattg tatacttata atgggaaact ttgcaaggac     2100

atttttggga agcaatgctg ggcagcgttt ttgccattga gggttgcaga atttgctctt     2160

tttgggatgg gttgccctga ataacattac ggaccaggta aataatttca tagaagttca     2220

gtatagtacg taattcttgt aagagtatcg tatgcaagct ctctgtatgc cacccactgt     2280

tagttcaaat tgagattttt gttttgtttt gttcttaaga acataccaag aaaataccag     2340

tgaattgttg gatatgaatt ccctgttagt tgatttaaat cctttctgaa taaagatcag     2400

ataaacagta actgaaggag catgtatagc tctttccttc aaattcaact agagcctttt     2460

taaaaagaca tttgcctgct agtcagatac atttacattt atgcaaattt tttaaatagg     2520

agaaaattaa gaaattgtgt taaaggccta aagttcagga gtgtattact ttaggttctt     2580

tccagtttgc tggttttttt tttttttttt tttttttttt ttgggcgggg gggaggttta     2640

tgaagttttg ctctttgaac cacagcttta ttatggtcct ttacactgga gacagacaca     2700

gagacactgt tcagaagatg aactaaactc agcagtggtc tggtatcaag agctttctga     2760

tgttttacag cctgaatttg gagggataac gatctgctgt gcctttgcag tcactgctta     2820

gcccaaagta atagtacttt tgataataac tcactctgtg cgatattcct gaataagtcc     2880

atctcaaaag tttgggattt tcctcctctt aactttctta atatttggac atgcagttgt     2940

cgccaaactt gggtattcat ggaatttcta gtaaatgaaa tacctatact ttgatactga     3000

agactgccaa atacatagga attttctttc ttaaaaaaca gtaatgaaga ctatatctcc     3060

tttcccagca ctgaatgttt tactagcact gggtgctcac catgcaactg aagaaaatgt     3120

ggaaactcaa aaggtcagga cagacttcca agcacttgca actgatgtta ctgtcttcaa     3180

ttttaataat tacacatatt tgtatatttc agagaagttt ttaatatttc tctgtccact     3240

ttttataagc tttaaaatga ttttctctgc cttgagattt gcatcaagaa aaagcacctc     3300

tcttcacctg aaagctttga agactagaga cacgctttac acgttttaac aagtatattg     3360

agtccacgtt tggtagcatc agttgttgag ttaaaaagaa aattattgca tttgatctgg     3420

atggatttta aaagaatata atgttcaata ttaaaaggat aattcacatt tgccaccata     3480

atgttctttt ttatgtaaaa agaagaactt ggagacatta acatgaaaaa gtcttttatc     3540

attagctcat gtatttgagg aagagcagct gtctttttat atgttttttg acaaatcata     3600

ttgtattctt ttgtacaaaa aagaactact tgtattctag aagaaatatg aaatgcttaa     3660

tttataagcg ggctggagat tttttccaat attgttttct ttgaaaatga aaggggatca     3720

tctattttag ttttggggtc tgggaacttt ttgaaaattt aatttgtgga ccaatgtttt     3780

gtgaaagcta aagagggcag gggttaaaat agggcttgaa tttctcattc tgtatagacc     3840

agcaaacttc cctgtgcaag gcaagtttac atcacaaatc caagaatgtt tgcatcctaa     3900

atgctagttt gcttcagccc ctagttaacc tcaggacttg gtttgcatat aaaaggtaga     3960

cagctgatat gttttcatga ataaatattg tcagccagaa aaggttggtg tcaggtaatg     4020

catatttttt taagctttgt tttatattta tttttcattt agtttttatt gggaatggtt     4080

ttcaaagaac tctcagttct gcctaggtgt ttttggggga gccctgtttt ccatagtgta     4140

attccattta agaggttgtc taaaagtctt tttaattaat agaaagattt taatatccaa     4200

gagtagtcaa attaaggata taaactttcc acaccttcct gtcgtgacag ataaaagcac     4260

agaaaggaca acccttgaaa tcatgtaacg ttggtcattt caatattttg tacctgtttt     4320

aaattctgtt agtgtattta cttcattgta aatatttttg agggtacctt tgtattttgc     4380

ttttgacctt ggttctgtga tttggatgtc aacaacttcc ctaaaaagca ccagtgtgtt     4440

aggttctaat gtcatgaccc aatttgtgtt attcatcttt aatcctgttt tcagtctcta     4500

tgtgtacagc agtattttta ataaagaatt acagagataa attt                      4544


<210> 552
<211> 2135
<212> DNA
<213> Homo sapiens

<400> 552
tttgatatga cgattagagc ataacccgag tgacacgttg aattcgccat aatcaaggaa       60

accttttccg ggtggggatc tctgaaatta ctcagataac agtgctgtgc caaaaacctg      120

tggattttct ctacaaaaat tattgagcaa ccctaattaa cctgattttt tgctgataat      180

cactctcaat ggaatcaaat cacaaatccg gggatggatt gagcggcact cagaaggaag      240

cagccctccg cgcactggtc cagcgcacag gatatagctt ggtccaggaa aatggacaaa      300

gaaaatatgg tggccctcca cctggttggg atgctgcacc ccctgaaagg ggctgtgaaa      360

tttttattgg aaaacttccc cgagaccttt ttgaggatga gcttatacca ttatgtgaaa      420

aaatcggtaa aatttatgaa atgagaatga tgatggattt taatggcaac aatagaggat      480

atgcatttgt aacattttca aataaagtgg aagccaagaa tgcaatcaag caacttaata      540

attatgaaat tagaaatggg cgcctcttag gggtttgtgc cagtgtggac aactgccgat      600

tatttgttgg gggcatccca aaaaccaaaa agagagaaga aatcttatcg gagatgaaaa      660

aggttactga aggtgttgtc gatgtcatcg tctacccaag cgctgcagat aaaaccaaaa      720

accgaggctt tgccttcgtg gagtatgaga gtcatcgagc agctgccatg gcgaggagga      780

aactgctacc aggaagaatt cagttatggg gacatggtat tgcagtagac tgggcagagc      840

cagaagtaga agttgatgaa gatacaatgt cttcagtgaa aatcctatat gtaagaaatc      900

ttatgctgtc tacctctgaa gagatgattg aaaaggaatt caacaatatc aaaccaggtg      960

ctgtggagag ggtgaagaaa attcgagact atgcttttgt gcacttcagt aaccgagaag     1020

atgcagttga ggctatgaaa gctttaaatg gcaaggtgct ggatggttcc cccattgaag     1080

tcaccctagc aaaaccagtg gacaaggaca gttatgttag gtatacccga ggcacaggtg     1140

gaaggggcac catgctgcaa ggagagtata cctactcttt gggccaagtt tatgatccca     1200

ccacaaccta ccttggagct cctgtcttct atgcccccca gacctatgca gcaattccca     1260

gtcttcattt cccagccacc aaaggacatc tcagcaacag agccattatc cgagcccctt     1320

ctgttagaga aatttacatg aatgtacctg taggggctgc gggagtgaga ggactgggcg     1380

gccgtggcta tttggcatac acaggcctgg gtcgaggata ccaggtcaaa ggagacaaaa     1440

gagaagacaa actctatgac attttacctg ggatggagct caccccaatg aatcctgtca     1500

cattaaaacc ccaaggaatt aaactcgctc cccagatatt agaagagatt tgtcagaaaa     1560

ataactgggg acagccagtg taccagctgc actctgctat tggacaagac caaagacagc     1620

tattcttgta caaaataact attcctgctc tagccagcca gaatcctgca atccaccctt     1680

tcacacctcc aaagctgagt gcctttgtgg atgaagcaaa gacgtatgca gccgaataca     1740

ccctgcagac cctgggcatc cccactgatg gaggcgatgg caccatggct actgctgctg     1800

ctgctgctac tgctttccca ggatatgctg tccctaatgc aactgcaccc gtgtctgcag     1860

cccagctcaa gcaagcggta acccttggac aagacttagc agcatataca acctatgagg     1920

tctacccaac ttttgcagtg actgcccgag gggatggata tggcaccttc tgaagatgct     1980

tttttaaatt taagaataag acacacaaaa ctctattaaa aaaaaaaaag aaataaacct     2040

ctaactcggt ccccaatgat cataaataat atgtttccta aagaaatgcc tttccagaga     2100

ctgtatagct tataccaatt atagaatcat gaagt                                2135


<210> 553
<211> 1718
<212> DNA
<213> Homo sapiens

<400> 553
aagctgcttc cagtgaatgc tacacacctg caccatggtt tgtccgacat ccttagccaa       60

gatcaggatt ggctatgttg gtacttacat atcctcatga gaattgtggt tctggtacta      120

gtttggtaaa gaaattatta aacctagctg atgcttgaag gtagttggat taacagaaga      180

gaagacaaac ttggagtata ttctttagta catttttccc caaagatgtt gggttcagtt      240

gccacaacac tgccattgtc atcttcaaat tccagtggaa tgcctcttgg ttactatctg      300

tctagtcctc agattagtag agtaactata tcaacaactg gacaattgac ttctaaagct      360

actgtaggta gctgttccag agtggaaaac agcttggatg ccagcccctt ctcagttccg      420

aagaaacagg atgaatcacc catgattggg gatggagaag attatttcct ttctttgttt      480

ggtgattcaa agaaacttac agcacactca aactacactc agaaaacttt aaaatacttt      540

tctatgattc ttgaagaagt tggccaattt acctccagtt ctcttggaga tgttgaaata      600

gctgaagtga atgtcaaggg tttgttcgtg aagctcatta actcttccct tgacaaagaa      660

atggcaattg gagatcatat tctccagcaa aatgtgaatg gacaaaccat ttctttgtac      720

cgattccttc caaacatcgt aatgcaggca aattccacag taacagtgtg ggcagcagca      780

tctgaagcaa agcatcaacc tccatcagat tttctttgga aggaacaaga caagtttaga      840

gcaagtcctg attgtataac aatcctgtgc aaaccgaacg gtcaagccat tgcgtggtac      900

acccctatcc actggaagca agcgtgggaa aaattagatg ctgacgttga atttaacaga      960

tgttcagtag tatctccaac attccgaaag cgtgtgtttc agtggacagc atctacagct     1020

acaataacta aagaaaaaca agatcaacct aagaaagata tctcaaatta tcaggtggaa     1080

caagctcaag ttcttcttaa gagagagaag gaaatcccac caaccgtttt ccctaatcgc     1140

agcccttggt gccagaatcc ctatgtctct gcacatcctt actgtcctct gattgaacca     1200

cacaatacat ccaccgctgg aggcagattg gatagacagc ccaggactcg gtcaaccaga     1260

cctaatcgag cctcagggtc taagaaaaag aagacatctg agtcacaaaa gcaataagca     1320

gtcaactcaa cctttaaagt aatctagtcc accctcaacc agctactaga aaagcaaaag     1380

agaactcaaa tccctgaggc ctgctctgca acctccctgc tattccatga gagggtgaag     1440

acatcacatt tctatatgga aaaaggatcc aaaatttgta ttgctgtaga attggtgaat     1500

tatagatgct tgatgaaatc acaagtccta ccactcctgc cttccaaatc cctgcagaaa     1560

acaagcagat ggttagtatt attcaatgga taaaattgct atttgcctta gatttctctt     1620

tttgtaaaca aagttatttt gggtacagaa ctcacaaaag aagagcacgt gcaattgttt     1680

aaccatttta cattgactga taaatctctt ttttccat                             1718


<210> 554
<211> 1389
<212> DNA
<213> Homo sapiens

<400> 554
tttcccggcg tccatttagt ggcgggaaaa gcgacctttt ctgagcgcgt ttgcctgttg       60

agtggtagcc tttcccctca accagcaatg gaggagcagc cccagatgca agacgccgac      120

gagcccgcgg actccggagg ggaaggccgg gcaggcgggc caccgcaggt cgccggcgcc      180

caggcggcgt gcagcgagga ccgcatgacc ctgctcctca ggctgagagc acagacaaaa      240

caacaactct tagaatataa atcaatggtt gatgcaagtg aagaaaaaac tccagaacaa      300

attatgcaag aaaagcaaat cgaagctaaa attgaagacc tggaaaatga aattgaagag      360

gtaaaagttg cttttgagat aaaaaagctt gcattagaca ggatgagact ttcaactgca      420

cttaaaaaaa acctggagaa aattagcaga cagtctagtg tgctcatgga taacatgaaa      480

cacctattag agctaaataa attaataatg aaatcacagc aggaatcttg ggatttagag      540

gaaaaactgc ttgatattag aaagaagaga ttgcaattaa aacaagcttc agaaagtaag      600

cttttagaaa tacagactga aaagaacaaa cagaagattg atttggacag tatggaaaac      660

tcagagagga taaagatcat acgacaaaac ctacagatgg agataaaaat tactactgtt      720

attcaacatg tgttccagaa ccttattttg gggagtaaag tcaattgggc agaggatcct      780

gcccttaagg aaattgttct gcagcttgag aagaatgttg acatgatgta ataagaattc      840

atttctgaca tattttacat ttctggcaat ctcaactctt atttggaata cttctgtgca      900

tttgtctgtc caccgtaatt ttagaaaagc atatccataa cgtttacagt tgtagtacag      960

ttgtggttag ttatttgtag tgggattgaa agtaattttt ttctttttat atttctatat     1020

ttagtttgtt tttttgttgt tgttgttttt tgagatggag tctcgctttg ttgcccagac     1080

tggagggcag tggcgcgatc tcggctcact gcaacctctg cctcccgggt tcaagcagtt     1140

ctgcctcagc ctcccaagta gctgtgacta aaggtgcacg ccgccatgcc cagctaattt     1200

tttgtatttt agtagagacg gggtttcacc gtgttgccca ggctgctctc agaactcctg     1260

agctcaggca gtccaccgcc tcggcctacc gaagtgctag gattacagac gtaagccacc     1320

gagcctggtc tagtttgcat tttttttcta tcagttttat aagttaagaa ataaaaggaa     1380

ttaatgtta                                                             1389


<210> 555
<211> 1612
<212> DNA
<213> Homo sapiens

<400> 555
actttcacct ttcctggtga tgcctttggc tccttgagct gagttttgcc cgagtggggc       60

tcatgaggga ggatggagtt tcttgggact actcagaccg ccagttactg tggtcccaag      120

aaatgctgtg gcttgacctc actgccagct gtacaggcgc cagtgatcca ggaatgctat      180

cagccctact acctgcccgg gtaccgctac ctcaattcat ggaggcctag cctcttctac      240

aagatagcca acgtccagac ctgcccggac gagagcacca gtaccctgcg gccgcccacc      300

atcctgccca cactgcgctc cgcactcttc tctcgctata gcccccacga ctgggaccag      360

tccaaccagc tgcaggtgcg tggggccgag gcctcccggc tgtgggccag ccggctgacg      420

gatgactcca tgaggctctt gcaggacaag gaccagctga cgcaccagat gcaggagggc      480

acctgccgga acctgggcca gaggctgtcg gacattggct tctggaagtc agagctgagc      540

tatgagctgg acaggcttct gactgagaac cagaacttgg agacggtcaa gaggcggctg      600

gagtgcgcgg ccaatgaggt gaactgccca ttgcaggtgg ccttggagtg tctgtaccat      660

cgagagaaga ggattgggat tgatttggtc catgacaacg tggagaaaaa ccttatccgg      720

gaagtggatt tgctaaaatg ttgccaagaa cagatgagaa aattagctca aagaattgat      780

atccagatgc gggataaccg ggatgctcag cacgtgctgg agagggacct cgaagacaaa      840

agctcggccc agtgtatcga tgagaagtgc tttaacctga gaaatacgtc agactgcatc      900

agcttcttcc acggcatgga gaaaattgac ggcacgatct ccgtacctga gacctgggcc      960

aagttcagta acgacaacat caaacactct cagaacatgc gggccaactc catccagctg     1020

cgggaggagg cggagcacct ctttgagacc ttgtcggatc agatgtggag gcagttcaca     1080

gacaccaacc tggccttcaa cgcccgcatc tctgaggtga cggatgtgaa gaataagctg     1140

cagacgcagc tggcgaagac gctgcaggag atcttccagg ccgagaacac catcatgctg     1200

ctggaaaggt ccatcatggc caaggagggc ccgctgaagg tggcccagac aaggctggag     1260

tgccggaccc ggcgccccaa catggagctg tgcagggaca tcccgcagtt gaagctggtg     1320

aacgaggtgt tcaccatcga cgacaccctg cagaccctca agctgcggct gcgggagaca     1380

caggacacgc tgcagctgct ggtcatgacc aagtgccggc tggagcacga gctcgccatc     1440

aaggccaaca ccctctgcat cgacaaggag aagtgcatgg gcatgcgtaa gaccttcccc     1500

tgcaccccgc gcctggtggg ccacacctga gcaccgccct ggcgcctcat tccgcgctgg     1560

cgtaaaattg gaaaaggctg agaaacaaag taaaacagta ttttgtttga aa             1612


<210> 556
<211> 1198
<212> DNA
<213> Homo sapiens

<400> 556
acagttttca caaaggtctc ttgatatcaa aacttctttc cttgcatgct tctctgatcc       60

tgtggagatg aaaattgaca tccatagtca tattctacca aaagaatggc cagatctaaa      120

aaagaggttt ggctacggag gctgggtgca gctccaacac cacagcaagg gagaagcaaa      180

gttgttgaaa gatgggaaag tcttcagagt ggtgcgagag aattgctggg atccagaagt      240

tcgtattaga gaaatggacc aaaaaggcca aacctgagga cactttaaac ctgtgccagc      300

ttttaaacaa cgaccttgcc agcaccgttg tgagctaccc caggaggttc gtgggtctgg      360

ggacgttgcc catgcaggcc cctgagctgg cggtcaagga gatggagcgc tgtgtgaaag      420

agctgggctt tcccggggtc caaattggca cccacgtcaa cgagtgggac ctgaacgcgc      480

aggagctctt tcctgtctat gcggcagccg aaaggctgaa gtgttccctg ttcgtgcatc      540

cctgggacat gcagatggat ggacgaatgg ccaaatactg gctcccttgg cttgtaggaa      600

tgccagcaga gaccaccata gccatttgct ccatgatcat gggtggagta tttgagaagt      660

ttcccaaact gaaagtgtgt ttcgcacatg gtggtggtgc cttccccttc acagtgggaa      720

gaatctccca tggattcagc atgcgcccag atctgtgtgc ccaggacaac cccatgaacc      780

cgaagaaata ccttggttcc ttttacacag atgctttggt tcatgatcct ctgtccctca      840

agctgttaac agatgtcata ggaaaggata aagtcatttt gggaaccgat tacccctttc      900

cactaggtga gctggaacct gggaaactaa tagagtccat ggaagaattt gatgaagaaa      960

caaagaataa actcaaagcc ggcaatgccc tggcattttt gggtcttgag agaaaacaat     1020

ttgaatgact gaatttacta caaaggcaaa ctttcaaaag gatatctcat ttttgtttct     1080

aaatatgtat caacaggtat caacaaaatc ctattttgaa ctattttact cagaaatgaa     1140

tgtcccaaat atcctaaatt attcataata aaaatgattt gtaagtgttt tcattctg       1198


<210> 557
<211> 3704
<212> DNA
<213> Homo sapiens

<400> 557
cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag ccgcagccgc       60

agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg agtgagcgga      120

gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt tcctcgcctg      180

ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag cgacgccttt      240

ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg gacgacgagg      300

aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg ggcggggatt      360

ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc gatgaagagg      420

aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac cagatggagc      480

taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag gaggaggagg      540

ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa gatgagctcg      600

gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag cctcaaccgc      660

cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag gccgcgggga      720

agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg gcgaggcagg      780

gccagcagca ggcgggaggt aagaagaagg cggaaggcgg cggaggcggc ggtcgccccg      840

gggctccggc ggcgggggac ggcaaaacag aacagaaagg cggagataaa aagaggggtg      900

ttaaaagacc acgagaagat catggccgtg gatattttga gtacattgaa gagaacaagt      960

atagcagagc caaatctcct cagccacctg ttgaagaaga agatgaacac ttcgatgaca     1020

cagtggtttg tcttgatact tataattgtg atctacattt taaaatatca agagatcgtc     1080

tcagtgcttc ttcccttaca atggagagtt ttgcttttct ttgggctgga ggaagagcat     1140

cctatggtgt gtcaaaaggc aaagtgtgtt ttgagatgaa ggttacagag aagatcccag     1200

taaggcattt atatacaaaa gatattgaca tacatgaagt tcgtattggc tggtcactaa     1260

ctacaagtgg aatgttactt ggtgaagaag aattttctta tgggtattct ctaaaaggaa     1320

taaaaacatg caactgtgag actgaagatt atggagaaaa gtttgatgaa aatgatgtga     1380

ttacatgttt tgctaacttt gaaagtgatg aagtagaact ctcgtatgct aagaatggac     1440

aagatcttgg cgttgccttc aaaatcagta aggaagttct tgctggacgg ccactgttcc     1500

cgcatgttct ctgccacaac tgtgcagttg aatttaattt tggtcagaag gaaaagccat     1560

attttccaat acctgaagag tatactttca tccagaacgt ccccttagag gatcgagtta     1620

gaggaccaaa ggggcctgaa gagaagaaag attgtgaagt tgtgatgatg attggcttgc     1680

caggagctgg aaaaactacc tgggttacta aacatgcagc agaaaatcca gggaaatata     1740

acattcttgg cacaaatact attatggata agatgatggt ggcaggtttt aagaagcaaa     1800

tggcagatac tggaaaactg aacacactgt tgcagagagc cccccagtgt cttgggaaat     1860

ttattgagat tgctgcccga aagaagcgaa attttattct ggatcagaca aatgtgtctg     1920

ctgctgccca gaggagaaaa atgtgcctgt ttgcaggctt ccagcgaaaa gctgttgtag     1980

tttgcccaaa agatgaagac tataagcaaa gaacacagaa gaaagcagaa gtagagggga     2040

aagacctacc agaacatgcg gtcctcaaaa tgaaaggaaa ctttaccctc ccagaggtag     2100

ctgagtgctt tgatgaaata acctatgttg aacttcagaa ggaagaagcc caaaaactct     2160

tggagcaata taaggaagaa agcaaaaagg ctcttccacc agaaaagaaa cagaacactg     2220

gctcaaagaa aagcaataaa aataagagtg gcaagaacca gtttaacaga ggtggtggcc     2280

atagaggacg tggaggattc aatatgcgtg gtggaaattt cagaggagga gcccctggga     2340

atcgtggcgg atataatagg aggggcaaca tgccacagag aggtggtggc ggtggaggaa     2400

gtggtggaat cggctatcca taccctcgtg cccctgtttt tcctggccgt ggtagttact     2460

caaacagagg gaactacaac agaggtggaa tgcccaacag agggaactac aaccagaact     2520

tcagaggacg aggaaacaat cgtggctaca aaaatcaatc tcagggctac aaccagtggc     2580

agcagggtca attctggggt cagaagccat ggagtcagca ttatcaccaa ggatattatt     2640

gaatacccaa ataaaacgaa ctgatacata tttctccaaa accttcacaa gaagtcgact     2700

gttttcttta gtaggctaac tttttaaaca ttccacaaga ggaagtgcct gcgggttcct     2760

tttttagaag ctttgtgggt tgattttttt tcttttcttt tttgtacatt tttaattgca     2820

gtttaaaagt gaatcgtaag agaacctcag cattgtgcac gataagagaa tgtgtcagta     2880

tttcagggtt ctacatttta tctgtaaaat gtgacttttt ttttttttta tcacaacaga     2940

agtaaaatgt tgctttgtac ctggtgtctt ttattaagaa tttactcccc ccatttctca     3000

cagagaataa cagtcgggag tcattgtcac aatataatag aaatgttagc aaccagattc     3060

atgtaaggac taagtggtcc tcatgaattg cattaagact ctgtactgct catattacac     3120

tccatcctct ctgtagtttg ctgggtagtg gagggggtaa gctaaatcat agtttctgac     3180

aataactggg aaggtttttt cttaaaataa caatggaatt ggtataattg ggattgaaaa     3240

ctaaaacttg gaactaagat agagaagatg gagtgtatgt agaagggctg ttaaaaatgt     3300

aaaacttggt tgcattattt gtggaggctc aaacttgtga aggttaatac cataattttt     3360

ccatttgttc tgcattttga ttctgaaaag aaagctggct ttgcccattt cttattaaaa     3420

aaacttgttg taaatccagt tgtctaatgg gatctatatg aagttagcca tgtctgtatg     3480

cccttctccc acaaaatact gtataactag tgtgcttgta gtagttaact ccaccatctt     3540

tgtaagctaa tgaaattgtg agtcacccat ttatatctta atttttaatc atgtcagttc     3600

ttgaatgggt atctccttag cctgctgatt tctttttctt tctaaagaaa gtgggtggag     3660

aaattaattt agacgtttgt ttgcaataaa aagaattcat ttta                      3704


<210> 558
<211> 1570
<212> DNA
<213> Homo sapiens

<400> 558
tagtgtcacg tgaggccccg gtggcggcgc agctacggca agagagtgag aaggaaggga       60

agccggaagg ggcgcgagtg aagcaaagcg aggacagaca gctcgcagag ggcgaggggt      120

gcgtgtgcgt ccgcttctca cctcaggtct cccttcggcc ccgctgccct ccctcgcggc      180

tgggtgacag ctgggtccgg tccgtcgcgg gctgcctggg gtgcgaggat cgcgcacccc      240

gtcttcgcgc gctgtgcctg ccgccccgcc ccctcgtccc gcccgtcccg tcgcgtcgcg      300

tcccgtcccc tcgggtgctg ccagccgggt gctgatgcga gtcggtggca gcgaggacat      360

tttctgactc cctggcccct gacacggctg cactttccat cccgtcgcgg ggccggccgc      420

tactccggcc ccaggatgca gaatgtgatt aatactgtga agggaaaggc actggaagtg      480

gctgagtacc tgaccccggt cctcaaggaa tcaaagttta aggaaacagg tgtaattacc      540

ccagaagagt ttgtggcagc tggagatcac ctagtccacc actgtccaac atggcaatgg      600

gctacagggg aagaattgaa agtgaaggca tacctaccaa caggcaaaca atttttggta      660

accaaaaatg tgccgtgcta taagcggtgc aaacagatgg aatattcaga tgaattggaa      720

gctatcattg aagaagatga tggtgatggc ggatgggtag atacatatca caacacaggt      780

attacaggaa taacggaagc cgttaaagag atcacactgg aaaataagga caatataagg      840

cttcaagatt gctcagcact atgtgaagag gaagaagatg aagatgaagg agaagctgca      900

gatatggaag aatatgaaga gagtggattg ttggaaacag atgaggctac cctagataca      960

aggaaaatag tagaagcttg taaagccaaa actgatgctg gcggtgaaga tgctattttg     1020

caaaccagaa cttatgacct ttacatcact tatgataaat attaccagac tccacgatta     1080

tggttgtttg gctatgatga gcaacggcag cctttaacag ttgagcacat gtatgaagac     1140

atcagtcagg atcatgtgaa gaaaacagtg accattgaaa atcaccctca tctgccacca     1200

cctcccatgt gttcagttca cccatgcagg catgctgagg tgatgaagaa aatcattgag     1260

actgttgcag aaggaggggg agaacttgga gttcatatgt atcttcttat tttcttgaaa     1320

tttgtacaag ctgtcattcc aacaatagaa tatgactaca caagacactt cacaatgtaa     1380

tgaagagagc ataaaatcta tcctaattat tggttctgat ttttaaagaa ttaacccata     1440

gatgtgacca ttgaccatat tcatcaatat atacagtttc tctaataagg gacttatatg     1500

tttatgcatt aaataaaaat atgttccact accagcctta cttgtttaat aaaaatcagt     1560

gcaaagagag                                                            1570


<210> 559
<211> 1362
<212> DNA
<213> Homo sapiens

<400> 559
taagactcat ggacatagct ttaattatct ttgcctgacg cccaatacct gaaaattaag       60

atgttcatgc aagataaaga ggtaattttt ctcctcctcc cagtcatcac ccgtagcatc      120

cggttaagag gctctccacc tcgctcattt tggtctaact ggatttacac aaactcactg      180

tgcacgtgcc tggggcgggc aaacccggaa acgacgccga gtcccgcggg atccaggagg      240

agccaactgc gccggaggag gggtttcggc cgacacgtcg ggattggcgg ctgcagccag      300

gggtcctccg acgctgggct tccgtgagcg gcgctctgcc agatctctgg accggattcg      360

tcccattctc gtcctcatgg tggacaagaa actggtggtg gttttcggag gcacaggtgc      420

ccagggtggc tccgtggccc gcacactcct ggaagatggg acattcaagg ttcgagtggt      480

gacccgaaac cctaggaaga aggcagcaaa ggagctgagg ctgcaaggtg cagaagtagt      540

gcagggagac caagatgacc aggtcatcat ggagctggcc ctgaatgggg cttacgccac      600

cttcatcgtg accaattact gggagagctg cagccaggag caggaggtca agcaggggaa      660

gctgctcgct gatctggcca ggcgcctggg cctccactat gtggtctaca gcggcctgga      720

gaacatcaag aagctgacgg cagggagatt ggccgccgcg cactttgacg gcaaagggga      780

ggtggaggaa tatttccggg acattggcgt tcccatgacc agtgtgcggc tgccctgcta      840

ttttgagaac ctcctctccc acttcttgcc ccagaaagcc ccagacggaa agagctactt      900

gctgagcttg cccacaggtg acgttcccat ggatggcatg tccgtgtctg acctgggtcc      960

tgtggtgctc agccttttga agatgccaga aaaatacgtc ggccagaaca tcgggctgag     1020

cacttgcagg cacacggccg aggagtacgc tgccctgctc accaagcaca cccgcaaggt     1080

cgtgcacgat gccaagatga ctcctgagga ctacgaaaag cttggctttc ccggtgcccg     1140

ggacctggcc aacatgttcc gtttctatgc cctgagaccc gaccgtgaca tcgagctgac     1200

cctgagactc aaccccaagg ccctgacgct ggaccagtgg ctggaacagc acaaagggga     1260

cttcaacctg ctgtgacctg cccgcctcgc ggccccttgt ggggatcggg ggcaccagag     1320

gggcagaggc accaacatct gaataaagcc attgttctcc ca                        1362


<210> 560
<211> 2970
<212> DNA
<213> Homo sapiens

<400> 560
gagggcggga agggccctct gtggggctgc cattttggct gggacctaaa tgcagtaaag       60

gagcagctac gggaatatag agagtggggc ttccaggcag agaagcctgc agtgcaaagg      120

tctgcagaca acgacctggg cgtcttcaag ggacacaagg aatcatattg ccagaacaca      180

ttgtacaggt agccaggtgt cggtctccag cctgagaact ctggctgttg ttccttgtgt      240

cgtcccatat tcctgcctgg cctgcgatgg acatcagcaa gggcctccca ggcatgcagg      300

gaggcctcca catatggatc tctgagaacc ggaagatggt gccggtaccc gagggggctt      360

acgggaactt ttttgaggaa cactgctatg tcatcctcca cgtcccccag agcccgaagg      420

ccacgcaggg ggcgtccagc gacctgcact actgggtcgg gaagcaggcg ggtgcggaag      480

cgcagggcgc tgcggaggcc ttccagcagc gcctacagga cgagctgggg ggccagaccg      540

tgctgcaccg cgaggcgcag ggccacgagt ccgactgctt ctgcagctac ttccgcccgg      600

gaatcatcta caggaaggga ggcctagcat ctgacctcaa gcatgtggag accaacttgt      660

tcaacatcca gcgactgctg cacatcaaag ggaggaagca cgtgtctgcc actgaggtgg      720

agctctcctg gaacagcttt aataagggtg acatcttcct gctggaccta ggcaagatga      780

tgattcagtg gaatgggccc aagaccagca tttctgagaa ggctcggggg ctggctttga      840

cctacagcct ccgggacagg gaacgtggtg gtggtcgtgc acagattggt gtggtggatg      900

atgaggccaa agccccggac ctcatgcaga tcatggaggc tgtgctgggc cgcagggtgg      960

gcagcctgcg tgccgccacg cccagcaagg atatcaacca gctgcagaag gccaatgttc     1020

gcctgtacca tgtctatgag aagggcaaag acctggtggt cctggagttg gcgacccccc     1080

cactgaccca ggacctgctg caggaggagg acttctacat cctggaccag ggtggcttca     1140

agatctatgt gtggcaggga cgcatgtcta gcctccagga gagaaaggct gccttcagcc     1200

gggctgtggg cttcatccag gccaagggct acccgaccta caccaacgtg gaggtggtga     1260

acgacggcgc cgagtcggcc gcgttcaagc agctcttccg gacttggtct gagaagcggc     1320

gcaggaacca gaagctcggc gggagggata aatcgattca tgtaaagctg gacgtgggca     1380

agctgcacac ccagcctaag ttagcggccc agctcaggat ggtggacgac ggctctggga     1440

aggtggaggt gtggtgcatc caggacttac acaggcagcc cgtggacccc aagcgtcatg     1500

gacagctgtg tgcaggcaac tgctaccttg tgctctacac ataccagagg ctgggccgtg     1560

tccagtacat cctgtaccta tggcagggcc accaggccac tgcggatgag attgaggccc     1620

tgaacagcaa cgctgaggaa ctagatgtca tgtatggtgg cgtcctagta caggagcatg     1680

tgaccatggg cagcgagccc ccccacttcc tcgccatctt ccagggccag ctggtgatct     1740

tccaggagag agctgggcac catggaaagg ggcagtcagc atccaccaca aggcttttcc     1800

aagtgcaagg cactgacagc cacaacacca ggaccatgga ggtgccagcc cgtgcctcat     1860

ccctcaactc cagtgacatc ttcttgctgg tcacagccag cgtctgctac ctctggtttg     1920

ggaagggctg taatggtgat cagcgtgaga tggcacgggt ggtggtcact gtcatttcca     1980

ggaagaatga ggaaacggtg ctggagggtc aggagcctcc ccacttctgg gaggccctgg     2040

gaggccgggc cccctacccc agcaacaaga ggctccctga ggaggtcccc agcttccagc     2100

cacgactgtt tgagtgctcc agccacatgg gctgcctggt cctcgcagaa gtggggttct     2160

tcagccagga ggacctggac aagtatgaca tcatgttact ggacacctgg caggagatct     2220

tcctgtggct tggggaagct gcaagtgagt ggaaggaggc ggtggcctgg ggccaggagt     2280

acctgaagac tcacccagca gggaggagcc cggccacacc catcgtgctg gtcaagcagg     2340

gccatgagcc tcccaccttc attggatggt tcttcacttg ggacccctac aagtggacta     2400

gccacccgtc ccacaaggaa gtggtggatg gcagcccggc agcagcatca accatctctg     2460

agataacagc agaagtcaac aacttgcggc tatccagatg gccgggcaat ggcagggcag     2520

gtgccgtggc cctgcaggcc ctcaagggct cccaggacag ctcagagaat gatctggtgc     2580

gaagccccaa gtcggctggc agcagaacca gcagctccgt cagcagcacc agcgccacga     2640

tcaacggggg cctgcgccgg gaacaactga tgcaccaggc tgttgaggac ctgccagagg     2700

gcgtggaccc tgcccgcagg gagttctatc tctcagactc tgacttccaa gatatctttg     2760

ggaaatccaa ggaggaattc tacagcatgg ccacgtggag gcagcggcag gagaaaaagc     2820

agctgggctt cttctgaacc caagccctct cgactgcccc tatcccctgg accccaacat     2880

acctacaatg ctggggaggc cctgcttcca ctcccctcag aggcttttgg tcatcctctg     2940

cgtgtcagta aaagcaggca gcccatacga                                      2970


<210> 561
<211> 1581
<212> DNA
<213> Homo sapiens

<400> 561
ctcgccgctg ccccggctcc gccgctcgca gagagattcg gaggagcccg ggcggggggg       60

aggaggaggg ggaggaggga gcggagatct cggggctcgg agccggccgc cgctccgctc      120

cgatcgctgt ggggcttggt tttttggggg tgggggggcg ggggggctca gatatggagg      180

caaatgggag ccaaggcacc tcgggcagcg ccaacgactc ccagcacgac cccggtaaaa      240

tgtttatcgg tggactgagc tggcagacct caccagatag ccttagagac tattttagca      300

aatttggaga aattagagaa tgtatggtca tgagagatcc cactacgaaa cgctccagag      360

gcttcggttt cgtcacgttc gcagacccag caagtgtaga taaagtatta ggtcagcccc      420

accatgagtt agattccaag acgattgacc ccaaagttgc atttcctcgt cgagcgcaac      480

ccaagatggt cacaagaaca aagaaaatat ttgtaggcgg gttatctgcg aacacagtag      540

tggaagatgt aaagcaatat ttcgagcagt ttggcaaggt ggaagatgca atgctgatgt      600

ttgataaaac taccaacagg cacagagggt ttggctttgt cacttttgag aatgaagatg      660

ttgtggagaa agtctgtgag attcatttcc atgaaatcaa taataaaatg gtagaatgta      720

agaaagctca gccgaaagaa gtcatgttcc cacctgggac aagaggccgg gcccggggac      780

tgccttacac catggacgcg ttcatgcttg gcatggggat gctgggatat cccaacttcg      840

tggcgaccta tggccgtggc taccccggat ttgctccaag ctatggctat cagttcccag      900

gcttcccagc agcggcttat ggaccagtgg cagcagcggc ggtggcggca gcaagaggat      960

caggctccaa cccggcgcgg cccggaggct tcccgggggc caacagccca ggacctgtcg     1020

ccgatctcta cggccctgcc agccaggact ccggagtggg gaattacata agtgcggcca     1080

gcccacagcc gggctcgggc ttcggccacg gcatagctgg acctttgatt gcaacggcct     1140

ttacaaatgg ataccattga gcaggtgctt tcgttgccat ctcactctga gagcatacct     1200

ggatgtccag gcaagactgg gcgaagtttc tgagtggccc tttgtttagg tgatgtcctc     1260

agacctggac ccccaccagc ctcactcccc atcccaacca gagatggctc acttcggatc     1320

gagggttgac tacatctcat catctcacga atctgctgta atataagaca acagctttta     1380

aatgtgtata taacccatga tttcggtttt gttttgtttt gtttttcttg atggtttccc     1440

tctccctccc tctcttccca ttctcctttt aaatctcttt gaatcacatt tggtagtgat     1500

tttgacttag tccagtagtc acatagcttt aatatctagt tcaaagctaa ccatagtata     1560

attgttatat taaggagtta t                                               1581


<210> 562
<211> 2129
<212> DNA
<213> Homo sapiens

<400> 562
gggacagagc tggctcacaa gccctccctg ctctgtgaca tgtctgtttc ctgtttctcc       60

cccatcagga gcagtttcag tctcaacttc aaaagaacaa acgcgcactc aaaacaaagg      120

aagaccgtcc tcgactgcag aggaagcagg aagctgtcgg cccagctctg agcccagctg      180

ctggagcccc gagcagcggc atggagtccg tggccctgta cagctttcag gctacagaga      240

gcgacgagct ggccttcaac aagggagaca cactcaagat cctgaacatg gaggatgacc      300

agaactggta caaggccgag ctccggggtg tcgagggatt tattcccaag aactacatcc      360

gcgtcaagcc ccatccgtgg tactcgggca ggatttcccg gcagctggcc gaagagattc      420

tgatgaagcg gaaccatctg ggagccttcc tgatccggga gagtgagagc tccccagggg      480

agttctctgt gtctgtgaac tatggagacc aggtgcagca cttcaaggtg ctgcgtgagg      540

cctcggggaa gtacttcctg tgggaggaga agttcaactc cctcaacgag ctggtcgact      600

tctaccgcac caccaccatc gccaagaagc ggcagatctt cctgcgcgac gaggagccct      660

tgctcaagtc acctggggcc tgctttgccc aggcccagtt tgacttctca gcccaggacc      720

cctcgcagct cagcttccgc cgtggcgaca tcattgaggt cctggagcgc ccagaccccc      780

actggtggcg gggccggtcc tgcgggcgcg ttggcttctt cccacggagt tacgtgcagc      840

ccgtgcacct gtgagcagcc cggcggccga tctggccaac gggccttttt acaggaactg      900

aggtccagag aggacatgga cacccccagc tctgtcagag tcacacgggg ctcagtggac      960

ggccttggac tgaacgtggg ctcctaactg cctccggccg ctctgcacaa actgggatgg     1020

cccaggtccc ccagcaaggg tacccagcaa gggtagctcc ggggcttcct ggctggttgc     1080

tttccattgg ctgccagctg tgtgacacca cagggcggag tctgtggagg ccccgcccac     1140

ctcctcttgt caatggcccc atctgccagg aaggttgagg actcccaggt ttcacccact     1200

ggaggctcaa cctaaggaac cctggccatg gtgggtgggt tcaccttggg ctgaccaccc     1260

actgggcctg cctgcccctc cctcaaaagg cccctggagt tgttcaggct gttgggaggt     1320

ggctcagcct cgaaggacag actgcacacc tgttgaccta aactcactgg acagactcca     1380

ggtggacacc aactcctcaa cagccccatg acttcagctc cacctggggc acccagcacc     1440

ccaccacagg gctagaggcc ctaagaccct gaaaaagggg cgggcagtag ggaaggtgga     1500

ggcacactcc tcttctgttg gacaggtgag ctctgagggc aagccctggg cccagccacg     1560

cagagaccct ggctgccctg gctcttgttt gtttaggccc aggttctgcc cagaccgggg     1620

cccagcagag ctctcaggag gctgagaaac ctccagggca gacagaaagt tggggccaga     1680

gctaggtttt agagatccta caggatccca catgggacgg ctacctaggt ggggcacggc     1740

ccctacccga gaacaggagg gtcctccaga gaatgtgcca tgatcaggga tatgagcagg     1800

gcctgcccag agcctgggca cctttgggag agggaaaagt gaggtgggac ttggaaaggc     1860

tttgaacgcc aggctgatgg ttgagggatg gtgggcaggg agggagggcg aagaggctcc     1920

ctctggcatt tgggagccgg tgggtggagg gaggagccct tggaggtggc tgcagtccct     1980

taatgggggg ccttgctctg ggcatgtggg gctcttcctc catccagagc tggcccaaga     2040

cccttagaac cctgagtgct ggcaaatctc actgctcctg acccagcctg tgtattcaaa     2100

acgaaaacag taaaaccaac atcaggatg                                       2129


<210> 563
<211> 898
<212> DNA
<213> Homo sapiens

<400> 563
cccgagcgcc ggccgggcca tgacccccgc tgctctgtct tgcaggctcg tcgccgcggc       60

cccccgagcc cgaccgccgc cgccaccacc accagcgccc gggcgggcct cgcgcgcctc      120

gggcgcggct ccgcagtgag cccaccaaga aggaagcggc ctgcagaggt gccgacatgg      180

ggcttaagat gtcctgcctg aaaggctttc aaatgtgtgt cagcagcagc agcagcagcc      240

acgacgaggc ccccgtcctg aacgacaagc acctggacgt gcccgacatc atcatcacgc      300

cccccacccc cacgggcatg atgctgccga gggacttggg gagcacagtc tggctggatg      360

agacagggtc gtgcccagat gatggagaaa tcgacccaga agcctgagga ggtgtcctgg      420

gtttggctgg ctggctcctg ctccagcggc ccggcttcag gtgtccgggg gcgtggctgc      480

ctggagcagg tgtgctgaat accctggatg ggaactgagc gaacccgggc ctccgctcag      540

agagacgtgg caggaccagc gaggaatcca gcctgtccac ttccagaaca gtgtttccca      600

ggccccgctg agtggaccgg acctctgaca cctccaggtt cttgctgact ccggcctggt      660

gaaagggagc gccatggtcc tggctgttgg ggtcccaggg agaggctctc ttctggacaa      720

acacaccctc ccagccccca gggctgtgca aacacatgcc cctgccataa gcaccaacaa      780

gaacttcttg caggtggagt ggctgttttt tataagttgt tttacagata cggaaacagt      840

ccaaaatggg atttataatt tcttttttgc attataaata aagatcctct gtaacaaa        898


<210> 564
<211> 20432
<212> DNA
<213> Homo sapiens

<400> 564
tgcctcccag cctgtgcccc cagcctgcgt gctgcccaga gcccccatag agagaggtcc       60

ccgccgccac cctcatggat cagccacagt tcagcggggc gccccgcttt ctcacccggc      120

ccaaggcctt cgtggtgtcg gtgggcaagg acgccaccct cagctgccag atcgtgggta      180

atcccacgcc acaggtgagc tgggagaagg accagcagcc ggtggcggcc ggcgcgcgct      240

tccgtctggc ccaggacggc gacctctacc gcctcactat cctggacctg gcgctgggcg      300

acagtgggca atacgtgtgc cgcgcgcgca atgccatagg cgaggccttc gctgctgtgg      360

gcctgcaggt ggacgcggag gccgcgtgcg ccgagcaggc gccgcacttc ctgctgcggc      420

ccacgtccat ccgcgtgcgc gagggctcag aggccacctt ccgctgccgc gtgggtggct      480

ccccgaggcc ggcagtgagc tggtccaagg acgggcggcg cctgggtgag cccgacggcc      540

cccgcgtgcg cgtggaggag ctcggcgagg caagtgcgct gcgcattcgg gcggcgcggc      600

cgcgcgacgg cggcacttac gaggtccgcg ccgagaaccc gctgggcgct gccagcgccg      660

ccgcggcgct agtggtggac tcggacgccg cggacacggc cagccggccc gggacctcca      720

cggccgcgct cctggcgcac ctgcagcggc ggcgcgaggc tatgcgcgcc gagggcgccc      780

ccgcctcacc gcccagcacc ggcacgcgca cctgcacggt gactgaaggc aagcacgcgc      840

gcctcagctg ctacgtgacc ggcgagccca agcccgagac ggtgtggaag aaggacggcc      900

agctggtgac cgagggccgg cgccacgtgg tgtacgagga cgcgcaggag aacttcgtgc      960

tcaagatcct cttctgcaag cagtcggacc gcggcctcta cacctgcacg gcgtccaacc     1020

tcgtgggcca gacctacagc tctgtgctgg tcgtagtgcg cgagcccgcg gttcccttca     1080

aaaagcggct gcaagatctg gaggtgcggg agaaggagtc ggccacgttc ctatgtgagg     1140

tgccccagcc gtccactgag gccgcgtggt tcaaggagga gacgcggttg tgggcgagcg     1200

ccaagtacgg catcgaggag gagggcaccg agcgccgcct gaccgtgcgc aatgtctcgg     1260

ccgacgacga cgcggtgtac atctgcgaga cgccagaggg cagccgcacg gtggcggagc     1320

tcgcagtcca aggaaacctc ctccgaaagc tccctcggaa gacggcggtg cgcgtgggcg     1380

acacggctat gttttgcgtg gagctggcgg tcccggtggg ccccgtccac tggctgcgga     1440

accaggagga agtggtggcg gggggccgcg tggccatctc cgcggagggc acgcgccaca     1500

cactaaccat ctcccagtgc tgcctggagg atgtgggcca ggtggccttt atggctggcg     1560

actgccagac gtccacccag ttctgcgtgt cggcccccag gaagcctccc ctgcaacccc     1620

ctgtggatcc tgtggtaaag gccaggatgg agagttccgt gattctcagc tggtccccac     1680

caccccatgg ggaacgccct gtcactatcg acggctacct ggtagagaag aagaagcttg     1740

gcacctacac ctggatcagg tgccacgagg ctgaatgggt ggctacacct gagctgaccg     1800

tggctgatgt ggcggaggag gggaacttcc agttccgagt gtccgctctc aacagctttg     1860

gtcagagtcc ctacctcgag ttcccgggga ctgtccacct ggcccccaag ctggccgtga     1920

ggacaccgct gaaggcggtg caggcggtag agggtggcga ggtcactttc tccgtggacc     1980

tcacggtggc ctcagcgggt gagtggttcc tggatgggca ggccctgaag gccagcagtg     2040

tgtatgagat ccactgtgat cgcacccggc acacgctcac catccgggag gtgcccgcca     2100

gcctgcacgg ggcgcagctg aagttcgtgg ccaacggcat tgagagcagc atccggatgg     2160

aggtccgggc ggccccaggg ctgactgcca acaagccgcc agccgcagct gcccgggagg     2220

tgctggctcg gctgcacgag gaggcgcagc tgctggctga gctgtcagat caggctgcgg     2280

ctgtgacgtg gctgaaggat ggtcgcacac tgtccccagg ccccaagtat gaggtgcagg     2340

catcggccgg gcggcgggtg ctccttgtgc gagatgtggc ccgggacgat gcaggcctct     2400

acgagtgcgt cagccgcggg ggccgcatcg cctaccagct ctccgtgcaa ggcctcgcgc     2460

gctttctgca caaggacatg gcgggcagct gtgtggatgc cgtggctggg ggcccggcgc     2520

agtttgagtg tgagacctcc gaagcccacg tccacgtgca ctggtacaag gatggcatgg     2580

agctgggcca ctccggtgag cgcttcttgc aggaggatgt ggggacgcgg caccggctgg     2640

tggcagccac agtcaccagg caggatgaag gcacctactc ctgccgcgtg ggcgaggact     2700

ctgtggactt ccggctccgc gtctctgagc ccaaggtggt gtttgctaag gagcagctgg     2760

cacgcaggaa gctgcaggca gaggcaggag ccagtgccac actgagctgc gaggtggccc     2820

aggcccagac ggaggtgacg tggtacaagg atgggaagaa gctgagctcc agctcgaaag     2880

tgtgcatgga ggccacaggc tgcacgcgca ggctggttgt gcagcaggca ggccaggcgg     2940

atgccgggga gtatagctgc gaggctgggg gccagcggct ctccttccat ctggatgtca     3000

aagagcccaa ggtggtgttt gccaaggacc aggtggcaca cagtgaggtg caggctgagg     3060

caggggccag tgccacgctg agctgcgagg tggcccaggc ccagacggag gtgatgtggt     3120

acaaagatgg gaagaagctg agctccagct tgaaagtgca tgtagaggcc aagggctgca     3180

gacggaggct ggtggtgcag caggcaggca agacagatgc cggggactac agctgcgagg     3240

ccaggggcca gagggtctcc ttccgcctgc acatcacaga gcccaagatg atgtttgcaa     3300

aggagcagtc agtgcataat gaggtgcagg ctgaggcggg ggccagtgcc atgctgagct     3360

gtgaggtggc ccaggcccag acggaggtga cgtggtacaa ggatgggaag aagctgagct     3420

ccagctcaaa agtgggcatg gaggtcaaag ggtgcacacg gaggctggtg ctgccacagg     3480

cgggcaaagc agatgctggg gagtacagct gtgaggctgg gggccagaga gtctccttcc     3540

acctgcacat cacagagccc aagggggtgt ttgcgaagga gcagtcagtg cataatgagg     3600

tgcaggctga ggcggggacc actgccatgc tgagctgtga ggtggcccag ccccagacag     3660

aggtgacgtg gtacaaggac gggaagaagc tgagctccag ctcaaaagta cgcatggagg     3720

tcaagggctg cacacgaagg ctggtagtgc agcaggtggg caaagcagat gctggggagt     3780

acagctgcga ggctgggggc cagagagtct cctttcaact gcacatcaca gagcccaagg     3840

cagtgtttgc caaggagcag ttggtgcata atgaggtgcg gactgaggca ggggccagtg     3900

ccacactgag ctgtgaggtg gcccaggccc agacagaggt gacgtggtac aaggatggga     3960

agaagctgag ctccagttcg aaagtgcgca tagaggctgc gggctgcatg cggcagctgg     4020

tggtgcagca ggcaggccag gcagatgctg gggagtacac ctgtgaggct gggggccagc     4080

ggctctcctt ccacctggat gtttcagagc ccaaggcggt gtttgcaaag gagcagctgg     4140

cacacaggaa ggtgcaggcc gaggcggggg ccattgccac gctgagctgc gaggtggccc     4200

aggcccagac agaggtgacg tggtacaagg acgggaagaa gctgagctcc agctcgaaag     4260

ttcgaatgga ggctgtgggc tgcacacgga ggctggtggt gcagcaggca tgccaggcgg     4320

acaccgggga gtatagctgc gaggccgggg gccagcggct ctccttcagc ctggacgtgg     4380

cagagcccaa ggtggtgttt gccaaggagc agccagtgca cagggaggtg caggcccagg     4440

cgggggccag caccacactc agctgcgagg tggctcaggc ccagacggag gtgatgtggt     4500

acaaggacgg gaagaagctg agcttcagct cgaaagtgcg catggaggct gtgggctgca     4560

cacggaggct ggtggtgcag caggcgggcc aggcggtcgc cggggagtac agctgcgagg     4620

cggggagcca gcggctctcc ttccacctgc acgtggcaga gcccaaggcg gtgtttgcca     4680

aggagcagcc agcgagcagg gaggtgcagg ctgaggcggg gaccagtgcc acgctgagct     4740

gcgaggtggc ccaggcccag acagaggtga cgtggtacaa ggacgggaag aaactgagct     4800

ccagctcgaa agtgcgaatg gaggccgtgg gctgcacacg gaggctggtg gtgcaggagg     4860

caggccaggc ggacgccggg gagtacagct gcaaggccgg ggatcagcgg ctgtccttcc     4920

acctgcacgt ggcagagccc aaggtggtgt ttgccaagga gcagccagca cacagggagg     4980

tgcaggctga ggcgggggcc agtgccacgc tgagctgcga ggtggcccag gcccagacag     5040

aggtgacgtg gtacaaggat gggaagaagc tgagttccag ctcgaaagtg cgcgtggagg     5100

ccgtgggctg cacacggagg ctggtggtgc agcaggcggg ccaggcagag gccggggagt     5160

acagctgcga ggcagggggt cagcagctct ccttccgcct gcaggtggca gagctggagc     5220

cccaaatttc agagagaccc tgccgcaggg agcctctggt ggtcaaggag catgaagaca     5280

tcatcctgac cgccacactg gccacaccct ctgcggccac ggtgacctgg ctcaaggatg     5340

gtgtggagat tcgccgcagc aagcggcatg agacagccag ccagggggac acccacaccc     5400

tgaccgtgca tggcgcccag gttctggaca gcgccatcta cagctgccgt gtgggcgcag     5460

aggggcagga cttcccagtg caggtggaag aggtggccgc caagttctgc cggctgctgg     5520

agcctgtgtg cggcgagctg ggtggcacgg tgacactggc ctgcgagcta agcccagcgt     5580

gtgcagaggt ggtgtggcgc tgcggcaaca cgcagcttcg ggtgggcaag cgcttccaga     5640

tggtggccga ggggcccgtg cgctcactca ctgtgttggg gctgcgcgca gaggacgcag     5700

gggagtacgt gtgtgagagc cgtgatgacc acaccagtgc gcagctcacc gtcagtgtgc     5760

cccgagtggt gaagtttatg tctgggctga gcaccgtggt cgcagaggag ggcggcgagg     5820

ccaccttcca gtgcgtggtg tcccccagtg atgtggcagt cgtgtggttc cgggacggtg     5880

ccctgcttca gcccagcgag aagtttgcca tatcacagag tggcgccagc cacagcctga     5940

ccatctcaga cctggtgctg gaggacgcgg gccagatcac cgtggaggct gagggcgcct     6000

catcctctgc tgccctgagg gtccgagagg cgcctgtgct gttcaaaaag aagctggagc     6060

cgcagacggt ggaggagcgg agctcggtga ccctggaggt ggagctgacg cggccgtggc     6120

cggagctgag gtggacacgg aacgcgacgg ccctggcgcc gggaaagaac gtggagatcc     6180

acgccgaggg cgcccgccac cgcctggttc tgcacaacgt aggttttgcc gaccgtggct     6240

tctttggctg cgagacgccg gatgacaaga cacaggccaa actcaccgtg gagatgcgcc     6300

aggtacggct cgtacggggc ctgcaggcag tggaggcacg ggagcagggc acggctacca     6360

tggaggtgca gctgtcgcat gcggacgtgg atggcagctg gactcgtgac ggtctgcggt     6420

tccagcaggg gcccacgtgc cacctggctg tgcggggccc catgcacacc ctcacactct     6480

cggggctgcg gccagaggat agtggcctta tggtcttcaa ggccgaagga gtgcacacgt     6540

cggcgcggct cgtggtcacc gagcttcccg tgagcttcag ccgcccgctg caggacgtgg     6600

tgaccactga gaaggagaag gttaccctgg agtgcgagct gtcgcgtcct aatgtggatg     6660

tgcgctggct gaaggacggt gtggagctgc gggcaggcaa gacgatggcc atcgcagccc     6720

agggcgcctg caggagcctc accatttacc ggtgcgagtt cgcggatcag ggagtgtatg     6780

tgtgtgatgc ccatgatgcc cagagctctg cctccgtgaa ggtacaagga aggacataca     6840

ctctcatcta ccggagagtc ctggcggaag atgcaggaga gatccaattt gtagccgaaa     6900

atgcagaatc gcgagcccag ctccgagtga aggagctgcc agtgaccctc gtgcgcccgc     6960

tgcgggacaa gattgccatg gagaagcacc gcggtgtgct ggagtgtcag gtgtcccggg     7020

ccagcgccca ggtgcggtgg ttcaagggca gtcaggagct gcagcccggg cccaagtacg     7080

agctggtcag tgatggcctc taccgcaagc tgatcatcag tgatgtccac gcagaggacg     7140

aggacaccta cacctgtgac gccggtgatg tcaagaccag tgcacagttc ttcgtggaag     7200

agcaatccat caccattgtg cggggtctgc aggacgtgac agtgatggag cccgctcctg     7260

cctggtttga gtgtgagacc tccatcccct cagtgcggcc acctaagtgg ctcctgggga     7320

agacggtgtt gcaggctggg gggaacgtgg gcctggagca ggagggcacg gtgcaccggc     7380

tgatgctgcg gcggacctgc tccaccatga ccgggcccgt gcacttcacc gttggcaagt     7440

cgcgctcctc tgcccgcctg gtggtctcag acatccccgt agtcctcaca cggccgttgg     7500

agcccaagac agggcgtgag ctgcagtcag tggtcctgtc ctgcgacttc cggccagccc     7560

ccaaggctgt gcagtggtac aaggatgaca cgcccctgtc tccctctgag aagtttaaga     7620

tgagcctgga gggtcagatg gctgagctgc gcatcctccg gctcatgcct gctgatgctg     7680

gtgtctaccg gtgccaggcg ggcagtgccc acagcagcac tgaggtcact gtggaagcgc     7740

gggaggtgac agtgacaggg ccgctacagg atgcagaggc cacggaggag ggctgggcca     7800

gcttctcctg tgagctgtcc cacgaggatg aggaggtcga gtggtcgctc aacgggatgc     7860

ccctgtacaa cgacagcttc catgagatct cacacaaggg ccggcgccac acgctggtac     7920

tgaagagcat ccagcgggct gatgcgggca tagtacgcgc ctcctccctg aaggtgtcga     7980

cctctgcccg cctggaggtc cgagtgaagc cggtggtgtt cctgaaggcg ctggatgacc     8040

tgtccgcaga ggagcgcggc accctggccc tgcagtgtga agtctctgac cccgaggccc     8100

atgtggtgtg gcgcaaagat ggcgtgcagc tgggccccag tgacaagtat gacttcctgc     8160

acacggcggg cacgcggggg ctcgtggtgc atgacgtgag ccctgaagac gccggcctgt     8220

acacctgcca cgtgggctcc gaggagaccc gggcccgggt ccgcgtgcac gatctgcacg     8280

tgggcatcac caagaggctg aagacaatgg aggtgctgga aggggaaagc tgcagctttg     8340

agtgcgtcct gtcccacgag agtgccagcg acccggccat gtggacagtc ggtgggaaga     8400

cagtgggcag ctccagccgc ttccaggcca cacgtcaggg ccgaaaatac atcctggtgg     8460

tccgggaggc tgcaccaagt gatgccgggg aggtggtctt ctctgtgcgg ggcctcacct     8520

ccaaggcctc actcattgtc agagagaggc cggccgccat catcaagccc ctggaagacc     8580

agtgggtggc gccaggggag gacgtggagc tgcgctgtga gctgtcacgg gcgggaacgc     8640

ccgtgcactg gctgaaggac aggaaggcca tccgcaagag ccagaagtat gatgtggtct     8700

gcgagggcac gatggccatg ctggtcatcc gcggggcctc gctcaaggac gcgggcgagt     8760

acacgtgtga ggtggaggct tccaagagca cagccagcct ccatgtggaa gaaaaagcaa     8820

actgcttcac agaggagctg accaatctgc aggtggagga gaaaggcaca gctgtgttca     8880

cgtgcaagac ggagcacccc gcggccacag tgacctggcg caagggcctc ttggagctac     8940

gggcctcagg gaagcaccag cccagccagg agggcctgac cctgcggctc accatcagtg     9000

ccctggagaa ggcagacagc gacacctata cctgcgacat tggccaggcc cagtcccggg     9060

cccagctcct agtgcaaggc cggagagtgc acatcatcga ggacctggag gatgtggatg     9120

tgcaggaggg ctcctcggcc accttccgtt gccggatctc cccggccaac tacgagcctg     9180

tgcactggtt cctggacaag acacccctgc atgccaacga gctcaatgag atcgatgccc     9240

agcccggggg ctaccacgtg ctgaccctgc ggcagctggc gctcaaggac tcgggcacca     9300

tctactttga ggcgggtgac cagcgggcct cggccgccct gcgggtcact gagaagccaa     9360

gcgtcttctc ccgggagctc acagatgcca ccatcacaga gggtgaggac ttgaccctgg     9420

tgtgcgagac cagcacctgc gacattcctg tgtgctggac caaggatggg aagaccctgc     9480

gggggtctgc ccggtgccag ctgagccatg agggccaccg ggcccagctg ctcatcactg     9540

gggccaccct gcaggacagt ggacgctaca agtgtgaggc tgggggcgcc tgcagcagct     9600

ccattgtcag ggtgcatgcg cggccagtgc ggttccagga ggccctgaag gacctggagg     9660

tgctggaggg tggtgctgcc acactgcgct gtgtgctgtc atctgtggct gcgcccgtga     9720

agtggtgcta tggaaacaac gtcctgaggc caggtgacaa atacagccta cgccaggagg     9780

gtgccatgct ggagctggtg gtccggaacc tccggccgca ggacagcggg cggtactcat     9840

gctccttcgg ggaccagact acttctgcca ccctcacagt gactgccctg cctgcccagt     9900

tcatcgggaa actgagaaac aaggaggcca cagaaggggc cacggccacg ctgcggtgtg     9960

agctgagcaa ggcagcccct gtggagtgga gaaaggggtc cgagaccctc agagatgggg    10020

acagatactg tctgaggcag gacggggcca tgtgtgagct gcagatccgt ggcctggcca    10080

tggtggatgc cgcggagtac tcgtgtgtgt gtggagagga gaggacctca gcctcactca    10140

ccatcaggcc catgcctgcc cacttcatag gaagactgag acaccaagag agcatagaag    10200

gggccacagc cacgctgcgg tgtgagctga gcaaggcggc ccccgtggag tggaggaagg    10260

ggcgtgagag cctcagagat ggggacagac atagcctgag gcaggacggg gctgtgtgcg    10320

agctgcagat ctgtggcctg gctgtggcag atgctgggga gtactcctgt gtgtgtgggg    10380

aggagaggac ctctgccact ctcaccgtga aggccctgcc agccaagttc acagagggtc    10440

tgaggaatga agaggccgtg gaaggggcca cagccatgtt gtggtgtgaa ctgagcaagg    10500

tggcccctgt ggagtggagg aaggggcccg agaacctcag agatggggac agatacatcc    10560

tgaggcagga ggggaccagg tgtgagctgc agatctgtgg cctggccatg gcggacgccg    10620

gggagtactt gtgtgtgtgc gggcaggaga ggacctcagc cacgctcacc atcagggctc    10680

tgcctgccag gttcatagaa gatgtgaaaa accaggaggc cagagaaggg gccacagctg    10740

tgctgcagtg tgagctgaac agtgcagccc ctgtggagtg gagaaagggg tctgagaccc    10800

ttagagatgg ggacagatac agcctgaggc aggacgggac taaatgtgag ctgcagattc    10860

gtggcctggc catggcagac actggggagt actcgtgcgt gtgcgggcag gagaggacct    10920

cggctatgct caccgtcagg gctctaccca tcaagttcac agagggtctg aggaacgaag    10980

aggccacaga aggggcaaca gccgtgctgc ggtgtgagct gagcaagatg gcccccgtgg    11040

agtggtggaa ggggcatgag accctcagag atggagacag acacagcctg aggcaggacg    11100

gggccaggtg tgagctgcag atccgcggcc tcgtggcaga ggacgctggg gagtacctgt    11160

gcatgtgcgg gaaggagagg acctcagcca tgctcaccgt cagggccatg ccttccaagt    11220

tcatagaggg tctgaggaat gaagaggcca cagaagggga cacggccacg ctgtggtgtg    11280

agctgagcaa ggcggcaccg gtggagtgga ggaaggggca tgagaccctc agagatgggg    11340

acagacacag cctgaggcag gacgggtcca ggtgtgagct gcagatccgt ggcctggctg    11400

tggtggatgc cggggagtac tcgtgtgtgt gcgggcagga gaggacctca gccacactca    11460

ctgtcagggc cctgcctgcc agattcatag aagatgtgaa aaaccaggag gccagagaag    11520

gggccacggc cgtgctgcaa tgtgagctga gcaaggcggc ccccgtggag tggaggaagg    11580

ggtctgagac cctcagaggt ggggacagat acagcctgag gcaggatggg accagatgtg    11640

agctgcagat tcatggcctg tctgtggcag acactgggga gtactcgtgt gtgtgcgggc    11700

aggagaggac ctcggccaca ctcaccgtca gggccccaca gccagtgttc cgggagccgc    11760

tgcagagtct gcaggcggag gagggctcca cggccaccct gcagtgtgag ctgtctgagc    11820

ccactgctac agtggtctgg agcaagggtg gcctgcagct gcaggccaat gggcgccggg    11880

agccacggct tcagggctgc accgcggagc tggtgttaca ggacctacaa cgtgaagaca    11940

ctggcgaata cacttgcacc tgtggctccc aggccaccag tgccaccctc actgtcacag    12000

ctgcgcctgt gcggttcctc cgagagctgc agcaccagga ggtggatgag ggaggcaccg    12060

cacacttatg ctgcgagctg agccgggcgg gtgcgagcgt ggagtggcgc aagggctccc    12120

tacagctctt cccttgtgcc aagtaccaga tggtgcagga tggtgcagct gcagagctgc    12180

tggtacgcgg agtggagcag gaggatgcgg gtgactacac gtgtgacacg ggccacacgc    12240

agagcatggc cagcctctct gtccgtgtcc ccaggcccaa gttcaagacc cggcttcaga    12300

gtctggagca ggagacaggt gacatagccc ggctgtgctg tcagctgagt gatgcagagt    12360

cgggggccgt ggtgcaatgg ctcaaggagg gcgtggagct gcatgcgggc cccaagtacg    12420

agatgcggag ccagggggcc acgcgggagc tgctgatcca ccaactggag gccaaggaca    12480

cgggcgagta tgcctgtgtg acaggcggcc agaaaaccgc tgcctccctc agggtcacag    12540

agcctgaggt gaccattgta cgggggctgg ttgatgcgga ggtgacggcc gatgaggatg    12600

ttgagttcag ctgtgaggtg tccagggctg gagccacagg cgtgcagtgg tgcctacagg    12660

gcctgccact gcaaagcaat gaggtgacag aggtggctgt gcgggatggc cgcatccaca    12720

ccctgcggct gaagggcgtg acgcccgagg acgctggcac tgtctccttc catttgggaa    12780

accatgcttc ctctgcccag ctcaccgtca gagctcctga ggtgaccatc ctggagcccc    12840

tgcaggacgt gcagctcagt gagggccagg atgccagctt ccagtgccgg ctatccagag    12900

cttcaggcca ggaggcccgc tgggctttag gaggggtgcc cctgcaggcc aacgagatga    12960

atgacatcac tgtggagcag ggcacactcc acctgctcac cctgcacaag gtgacccttg    13020

aggatgctgg aactgtcagt ttccacgtgg gcacgtgtag ctctgaggcc cagctgaaag    13080

tcacagccaa gaacacggtg gtgcgggggc tggagaatgt ggaggcgctg gagggcggcg    13140

aggcgctgtt cgagtgccag ctgtcccagc ccgaggtggc cgcccacacc tggctgctgg    13200

acgacgaacc cgtgcacacc tcggagaacg ccgaggtggt cttcttcgag aacggcctgc    13260

gccacctgct gctgctcaaa aacttgcggc cacaagacag ctgccgggtg accttcctgg    13320

ctggggatat ggtgacgtcc gcattcctca cggtccgagg ctggcgcctg gagatcctgg    13380

agcctctgaa aaacgcggcg gtccgggccg gcgcacaggc atgcttcacc tgcacgctca    13440

gcgaggcggt gcccgtggga gaggcgtcct ggtacatcaa tggcgcggca gtgcagccgg    13500

atgacagcga ctggactgtc accgccgacg gcagtcacca cgccctactg ctgcgcagcg    13560

cccagcccca ccacgccggg gaggtcacct tcgcttgccg cgacgccgtg gcctctgcgc    13620

ggctcaccgt gctgggcctc cctgatcccc cagaggatgc tgaggtggtg gctcgcagca    13680

gccacactgt gacactgtct tgggcagctc ccatgagtga tggaggcggt ggtctctgtg    13740

gctaccgcgt ggaggtgaag gagggggcca caggccagtg gcggctgtgc cacgagctgg    13800

tgcctggacc cgagtgtgtg gtggatggcc tggcccccgg ggagacctac cgcttccgtg    13860

tggcagctgt gggccctgtg ggtgctgggg aaccggttca cctgccccag acagtgcggc    13920

ttgcagagcc accgaagcct gtgcctcccc agccctcagc ccctgagagc cggcaggtgg    13980

cagctggtga agatgtctct ctggagcttg aggtggtggc tgaggctggt gaggtcatct    14040

ggcacaaggg aatggagcgc atccagcccg gtgggcggtt cgaggtggtc tcccagggtc    14100

ggcaacagat gctggtgatc aagggcttca cggcagaaga ccagggcgag taccactgtg    14160

gcctggctca gggctccatc tgccctgcgg ctgccacctt ccaggtggca ctgagcccag    14220

cctctgtgga tgaggcccct cagcccagct tgccccccga ggcagcccag gagggtgacc    14280

tgcacctact gtgggaggcc ctggctcgga aacgtcgcat gagccgtgag cccacgctgg    14340

actccattag cgagctgcca gaggaggacg gccgctcgca gcgcctgcca caggaggcag    14400

aggaggtggc acctgatctc tctgaaggct actccacggc cgatgagctg gcccgcactg    14460

gagatgctga cctctcacac accagctctg atgatgagtc ccgggcaggc accccttccc    14520

tggtcaccta cctcaagaag gctgggaggc caggcacctc accactggcc agcaaggttg    14580

gggccccagc agccccctct gtgaagccac agcagcagca ggagccactg gctgctgtgc    14640

gcccaccact gggagacctg agcaccaaag acctgggtga tccctcaatg gacaaggcag    14700

ctgtgaagat ccaggctgcc tttaagggct acaaggtccg gaaggagatg aagcagcagg    14760

aagggcccat gttctcccac acatttgggg acaccgaggc acaggtgggg gatgccctgc    14820

ggctggagtg tgtcgtggcc agcaaggcag atgtgcgagc ccgctggctg aaggatggtg    14880

tggagctgac cgatgggcgg caccatcaca tcgaccagct tggggatggc acctgctctc    14940

tgctgatcac tggcctggac cgtgctgatg ctggctgcta cacctgtcag gtgagcaaca    15000

agtttggcca ggtgacccac agtgcctgtg tggtggtcag tgggtcagag agtgaagccg    15060

agagctcctc tgggggtgag ctggacgatg ccttccgccg ggctgcccgt cggctgcacc    15120

ggctcttccg caccaaaagt ccggctgaag tttcagatga ggagctcttc ctgagtgcag    15180

acgagggccc tgcagagcca gaggagcccg cggactggca gacataccgc gaagatgagc    15240

atttcatctg catccgtttt gaggcgctca ctgaggcccg ccaggcggta actcgcttcc    15300

aggagatgtt tgccacactg ggcattgggg tggagatcaa gctggtggaa caggggcctc    15360

ggagggtaga gatgtgcatc agcaaagaga ctcctgcccc tgtggtgcct ccagagccat    15420

tgcccagcct actgacttct gacgctgccc cagtgttcct gactgagttg cagaaccaag    15480

aagtgcagga tgggtatcct gtgagctttg actgcgtggt gacaggtcag cccatgccca    15540

gtgtgcgctg gttcaaggat gggaagttgt tggaggagga tgatcactac atgattaatg    15600

aagaccaaca gggtggccat cagctcatca tcacagccgt ggtgccagca gacatgggcg    15660

tctaccgctg cctggccgag aacagcatgg gtgtctcctc caccaaggct gagctccgtg    15720

tggacttgac aagcacagac tatgacactg cagcagatgc cacggagtcc tcatcctact    15780

tcagtgccca aggctacctg tccagccggg agcaggaggg aacagagtcc accactgatg    15840

agggccagct gccccaggtg gtggaggagc tgagagacct ccaggtggcc cctggcacac    15900

gcctggccaa gttccagctc aaggtgaaag gctaccctgc tcccagatta tactggttca    15960

aagatggcca gcccctgacc gcatctgccc acatccgcat gactgacaag aagatcctgc    16020

acaccctgga gatcatctcc gtcacccggg aggactctgg ccagtatgca gcctatatca    16080

gcaatgccat gggtgctgcc tactcgtctg cccggctgct ggttcgaggc cctgatgagc    16140

cagaagagaa gcctgcatca gatgtgcatg agcagctggt gccgccccga atgctggaga    16200

ggttcacccc caagaaagtg aagaaaggct ccagcatcac cttctctgtg aaggtagaag    16260

gacgcccggt gcccaccgtg cactggctca gggaggaggc tgagagaggc gtgctgtgga    16320

ttggccctga cacaccgggc tacaccgtgg ccagctctgc gcagcagcac agcctggtcc    16380

tgctggacgt gggccggcag caccagggca cctacacatg cattgccagc aacgctgccg    16440

gccaggccct ctgctccgcc agcctgcacg tctcgggcct gcctaaggtg gaggagcagg    16500

agaaagtgaa ggaagcgctg atttccactt tcctgcaggg gaccacacaa gccatctcag    16560

cacaggggtt ggaaactgcg agttttgctg accttggtgg gcagaggaaa gaagagcctc    16620

tggctgccaa ggaggccctc ggccacctgt ccctcgctga ggtgggcaca gaggagttcc    16680

tgcagaaact gacctcccag atcactgaga tggtatcggc caagatcacg caggccaagc    16740

tgcaggtgcc cggaggtgac agtgatgagg actccaagac accatctgca tccccccgcc    16800

atggccgatc acggccatcc tccagcatcc aggagtcttc ctcagagtca gaggacggcg    16860

atgcccgagg cgagatcttt gacatctacg tggtcaccgc tgactacctg cccctagggg    16920

ctgagcagga tgccatcacg ctgcgggaag gccagtatgt ggaggtcctg gatgcagccc    16980

acccactgcg ctggcttgtc cgcaccaagc ccaccaagtc cagcccctca cggcagggct    17040

gggtgtcacc agcctacctg gacaggaggc tcaagctgtc acctgagtgg ggggccgctg    17100

aggcccctga gttccctggg gaggctgtgt ctgaagacga atacaaggca aggctgagct    17160

ctgtgatcca ggagctgctg agttctgagc aggccttcgt ggaggagctg cagttcctgc    17220

agagccacca cctgcagcac ctggagcgct gcccccacgt gcccatagct gtggccggcc    17280

agaaggcagt catcttccgc aatgtgcggg acatcggccg cttccacagc agcttcctgc    17340

aggagttgca gcagtgcgac acggacgacg acgtggccat gtgcttcatc aagaaccagg    17400

cggcctttga gcagtacctg gagttcctgg tggggcgtgt gcaggctgag tcggtggtcg    17460

tcagcacggc catccaggag ttctacaaga aatacgcgga ggaggccctg ttggcagggg    17520

acccctctca gcccccgcca ccacctctgc agcactacct ggagcagcca gtggagcggg    17580

tgcagcgcta ccaggccttg ctgaaggagc tgatccgcaa caaggcgcgg aacagacaga    17640

actgcgcgct gctggagcag gcctatgccg tggtgtctgc cctgccacag cgcgctgaga    17700

acaagctgca cgtgtccctc atggagaact acccaggcac cctgcaggcc ctgggcgagc    17760

ccatccgcca gggccacttc atcgtgtggg agggtgcacc gggggcccgc atgccctgga    17820

agggccacaa ccgtcacgtg ttcctcttcc gcaaccacct ggtaatctgc aagccccggc    17880

gagactcccg caccgatacc gtcagctacg tgttccggaa catgatgaag ctgagcagca    17940

tcgacctgaa cgaccaggtg gagggggatg accgcgcctt cgaggtgtgg caggagcggg    18000

aggactcggt gcgcaagtac ctgctgcagg cacggacagc cattatcaag agctcgtggg    18060

tgaaggagat ctgtggcatc cagcagcgtc tggccctgcc tgtgtggcgg cccccggact    18120

ttgaagagga gctggccgac tgcacagccg agctgggtga gacagtcaag ctggcctgcc    18180

gcgtgacggg cacacccaag cctgtcatca gctggtacaa agatgggaaa gcagtgcagg    18240

tggaccccca ccacatcctc attgaagacc ctgatggctc gtgtgcactc atcctggaca    18300

gcctgaccgg tgtggactct ggccagtaca tgtgcttcgc ggccagcgcc gctggcaact    18360

gcagtaccct gggcaagatc ctggtgcaag tcccaccacg gttcgtgaac aaggtccggg    18420

cctcaccctt tgtggaggga gaggacgccc agttcacctg caccatcgaa ggcgccccgt    18480

acccgcagat caggtggtac aaggacgggg ccctgctgac cactggcaac aagttccaga    18540

cactgagtga gcctcgcagc ggcctgctag tgctggtgat ccgggcggcc agcaaggagg    18600

acctggggct ctacgagtgt gagctggtga accggctggg ctccgcgcgg gctagtgcgg    18660

agctgcgcat tcagagcccc atgctgcagg cccaggagca gtgtcacagg gagcagctcg    18720

tggctgcagt ggaagtcact gagcaagaga ctaaagtccc caagaaaacc gtcatcatag    18780

aagagaccat caccactgtg gtgaagagcc cacgtggcca acgacggtcc cccagcaagt    18840

ccccctcccg ctcaccttcc cgctgctctg ccagcccgct gaggccaggc ctactggccc    18900

ccgacctgct gtacctgcca ggtgctggcc agccccgcag gccggaggca gaaccaggcc    18960

agaagcccgt ggtgcccaca ctgtatgtga cggaggccga ggcccactct ccagctctgc    19020

ccggactctc ggggccccag cccaagtggg tggaggtgga ggagaccatt gaagtccggg    19080

tgaagaagat gggcccgcag ggtgtgtctc ccaccacaga ggtgcccagg agctcatcgg    19140

ggcatctctt cacactgccc ggtgcgaccc ccggagggga ccccaattcc aacaactcca    19200

acaacaagct gctggcccag gaggcctggg cccagggcac agccatggtc ggcgtcagag    19260

agccccttgt cttccgcgtg gatgccagag gcagtgtgga ctgggctgct tctggcatgg    19320

gcagcctgga ggaggagggc accatggagg aggcgggaga ggaagagggg gaagacggag    19380

acgcctttgt gacggaggag tcccaggaca cacacagcct tggggatcgt gaccccaaga    19440

tcctcacgca caacggccgc atgctgacac tggctgacct ggaagattac gtgcctgggg    19500

aaggggagac cttccactgt ggtggccctg ggcctggcgc ccctgatgac cctccctgcg    19560

aggtctcggt gatccagaga gagatcgggg agcccacggt ggggcagcct gtgctgctca    19620

gcgtggggca tgcactgggt ccccgaggcc ctctcggcct ctttaggcct gagccccgtg    19680

gggcgtcacc accgggaccc caggtccgta gccttgaggg cacctccttc ctcttgcggg    19740

aggccccggc tcggcctgtg ggcagtgctc cctggacgca gtctttctgc acccgcatcc    19800

ggcgttctgc ggacagtggc cagagcagct tcaccacaga gctttccacc cagaccgtca    19860

acttcgggac agtgggggag acggtcaccc ttcacatctg cccagacagg gatggggatg    19920

aggcggcaca gccctgatgc tgctgccatg gtggcttggg gcagcgggga gaaaggagtg    19980

tccttgaggc ctaggacgct gcccggcctc agcagcagcc ctgggagcct cctgagggcc    20040

ctccctgtcc ctggccacgg gcccttctta cctcactcaa cttcagccag gaggactggg    20100

tggtgcttgc aatgttggaa tgaccggctc aaagacctca gctctgggct gtttcctgtc    20160

agcctggcag gagcctcagg actgtggacg aaggatgtgg ccttgggcat ttgtcctgtt    20220

cccacatggg cctggtccct ccctcctggc cccagccaca gctgccaggc ctgacatggc    20280

cttgcctctc ctgcagtctt ggtgactgag acccttgggt ggcgcttccc agctctgcag    20340

gccctcctgg ccttttctgc agggtggaca cagggtctgt gtgtgggcag cagcccctgt    20400

ctctcagcaa gaataaagca gcttcctgtg ca                                  20432


<210> 565
<211> 2715
<212> DNA
<213> Homo sapiens

<400> 565
cttccgcctc ggctcctctt cctgccggca tccgggatcc ctacgtcccg cgtcccccga       60

gcgctcggag cctacgcgcc cagcgctacc gaaacccaga gtcctgcgcc ctggagtccc      120

cgcgccccgg agcccgagca cccgggagtc ccgagcctcg cgccccggag tgcccgagcc      180

tgcgccgccg cacccggata ccccgcgtcc ccgcgagctg ccgaggccgc ccgccgccgc      240

cccgcggaca gtaccgcctt cctcccctct gtccgcgcca tggccgcccc cgacctgtcc      300

accaacctcc aggaggaggc cacctgcgcc atctgcctcg actacttcac ggatccggtg      360

atgaccgact gcggccacaa cttctgccgc gagtgcatcc ggcgctgctg gggccagccc      420

gagggcccgt acgcgtgccc cgagtgccgc gagctgtccc cgcagaggaa cctgcggccc      480

aaccgcccgc ttgctaagat ggccgagatg gcgcggcgcc tgcacccgcc gtcgccggtc      540

ccgcagggcg tgtgccccgc gcaccgcgag ccactggccg ccttctgtgg cgacgagctg      600

cgcctcctgt gtgcggcctg cgagcgctct ggggagcact gggcgcaccg cgtgcggccg      660

ctgcaggacg cggccgaaga cctcaaggcg aagctggaga agtcactgga gcatctccgg      720

aagcagatgc aggatgcgtt gctgttccaa gcccaggcgg atgagacctg cgtcttgtgg      780

cagaagatgg tggagagcca gcggcagaac gtgctgggtg agttcgagcg tcttcgccgt      840

ttgctggcag aggaggagca gcagctgctg cagaggctgg aggaggagga gctggaggtg      900

ctgccccggc tgcgggaggg cgcagcccac ctaggccagc agagcgccca cctagctgag      960

ctcatcgccg agctcgaggg ccgctgccag ctgcctgctc tggggctgct gcaggacatc     1020

aaggacgccc tgcgcagggt ccaggatgtg aagctgcagc ccccagaagt tgtgcctatg     1080

gagctgagga ccgtgtgcag ggtcccggga ctggtagaga cactgcggag gtttcgaggg     1140

gacgtgacct tggacccgga caccgccaac cctgagctga tcctgtctga agacaggcgg     1200

agcgtgcagc ggggggacct acggcaggcc ctgccggaca gcccagagcg ctttgacccc     1260

ggcccctgcg tgctgggcca ggagcgcttc acctcaggcc gccactactg ggaggtggag     1320

gttggggacc gcaccagctg ggccctgggg gtgtgcaggg agaacgtgaa caggaaggag     1380

aagggcgagc tgtccgcggg caacggcttc tggatcctgg tcttcctggg gagctattac     1440

aattcctcgg aacgggcctt ggctccactc cgggacccac ccaggcgcgt ggggatcttt     1500

ctggactacg aggctggaca tctctctttc tacagtgcca ccgatgggtc actgctattc     1560

atctttcccg agatcccctt ctcggggacg ctgcggcccc tcttctcacc cctgtccagc     1620

agcccgaccc cgatgactat ctgccggccg aaaggtgggt ccggggacac cctggctccc     1680

cagtgactcg ggccctcctg gaggagtcct gttgcctctc ctgcccctcc aggccactga     1740

gtgttttggc cacttggagg acctgggagg agggagtgtg tcctttgagc aagaggagga     1800

actcctggtg cctttctgag cctgcgtggg agaaccccaa ttctagcact ccaggaaact     1860

gtgggagagt gtggggcagg ctccgtcctc cctgggagac ccctccagcc accgggtgcc     1920

acttaatgcc aacagccctt accaaagctg ggagccccat tgccccggca gctctggcct     1980

gtggttccag aagctgagaa aactccactg gggcttgcag aatccagggt tcacctaagc     2040

tgcacagttc ctgcagcttt gccagccccc tgaaagtctt gtgtacccca cctctgaaga     2100

tgctggggga ggcagctggg atgggagcca gccccatgcc tgtctgtgac cccacagtgg     2160

gtgagagccc gtcacagtcc tgggtgtggc tgctctggaa gaattaggag gcagccataa     2220

taagagtctt cagagagatg atgggagggg ccagtgagga caggaacaga gagtagatgt     2280

cctataataa aggggcttct gggaggtgcc tgggcacaga tgtctgttca gcaggtgtgt     2340

gggcctagag gagagagcag agcccagaaa tgtcttttgc aggcccacgt tctgacttga     2400

agctttcgtg ggcatgttgc cattgggttt tgcccttgca aaggcttcct aggtctccag     2460

tggcccctca ggacccaggg tcccagctgc tgcttgggga tgtgcactgc tggccgccgg     2520

ccttgcagtc tctctaccct ggggaggaac agtggcttct cagagcctgg ggcatacaga     2580

agaaggcagg agttgatttt tgtgttgggt ttggggtttc tttgtcctca aggtactgtt     2640

ctgtttctct ttacccctct gctttattta ttgtaagcat tcccacgtta aataaacttt     2700

ggctgttgtc tacaa                                                      2715


<210> 566
<211> 5157
<212> DNA
<213> Homo sapiens

<400> 566
gagctgcgct ttagctgctg cgccacgcgc gcctcgggcc tgggcgcaga ggatcggccg       60

ggcgcggcgg gaaggaggct gcgggcagcg aggagcggct ggcgctcgag gcggcggacg      120

gcaccatgtc cccggggagc ggggtgaaga gcgagtacat gaagcgctac caggagccgc      180

gctgggagga gtacgggccg tgctaccgcg agctgctgca ctaccgccta ggccgccggc      240

tgctggagca ggcgcacgcg ccctggctct gggacgactg gggcccggcc ggctcctcgg      300

aggactcggc gtcgtcagag tcgtcgggcg ccgggggccc cgcaccccgg tgcgccccgc      360

cctcgccccc gccgcccgta gagccggcga cccaggagga ggcggaacgg cgggcgcgcg      420

gggccccgga ggagcaggac gcggaggccg gggacgcgga ggccgaggac gcggaggacg      480

cggctctgcc agcactgcca gtgaaagatg tagaagataa acctgaacaa caaaccagaa      540

caagagagac tgacaaatca cccaccagta ctgagcctcg acagcaacca agtgccttat      600

ttgctagagg aaacaggaaa gcggtcaaaa gtccccaaag atcatcgagt aaaataaaag      660

aaaacaagca tccatttgct ctttatggct ggggagaaaa acagaccgat acaggaagcc      720

agaagactca caacgtctgt gcgtccgctc ctgtgcacga gattcatgaa tcagcattac      780

gagccaagaa cagaagacag gtggaaaaaa ggaaactggt tgctcaaagg cagcgagctc      840

actctgtgga tgtggagaag aacagaaaga tgaaggcttc ctcctcagag aacccgtgga      900

tgacagaata catgaggtgc tattcggcaa gagcttaaag aaacacttgc gtggacagcc      960

tcttttaaaa agtgtaaatg actgaaagga aaaacaaaac aaaaaccatc aaaagaaacg     1020

gacacaggtt taagaaacca actgattatg caaggttttt tttagggaat ttgtaaaaga     1080

ttgttttatt ttgatgaata ttggtcacct acctcggcag tagggcagac agttgaagcc     1140

atagacattt ggttatttat gaagataatt ccctaaatct ttgatattct tataaggttt     1200

ttgttttaaa gcatcttaat cttttaagat actgacacca aatgccttta aatggcaaca     1260

gatgcttaca gttcagtatt cttttcataa gcttaggtag agcctattat catcttgttc     1320

taaataactt tccagattcc atagctataa gatcattcca tcctacagca taagactcgt     1380

tttccttata tgccgttttg tttgtgaaag aatatcaagt caaaaatgag tgtcagcact     1440

actactgatt ccatgtataa tgaaagtaga actttgctag ttcctgaaaa tttttaactt     1500

atttgtattt cagttcagca gcatctttat gtagattgtg atatttaaga attatctggg     1560

ctgggcgagg gtctcttttt ctctttcagt gatcatctag gcagttatta tttaatagtt     1620

taatagctca agtacattcc aatagacgaa gtgcacacaa cacaatatgt gtgtacagta     1680

gtagtaaagt ttcttttgag tagtcaaaga ctcacttttt ttattgcctt tttttttttt     1740

tttaaagaat acatactgtg gattcagtcc cttgtcacac ttgacctttt ggcatacacc     1800

cactgtggac ttttgcctct tctgtaatgg ctggcaatga catttcaaac ttacaatctg     1860

gaattgcact tggtacattg gcattgcttg ttccactggg atggggacca gtgtgaagat     1920

gcctgttaga tagactgccc acccctactt tctctttttc tttatagcac ttaacaataa     1980

caaagtcttg atgatgtaca gtattcaaac tttaggttga aatacgttac tctttgattc     2040

ctagccagta gatcttatct acactttaat gggagagaat ggtggtgtgt gggtaggcac     2100

aaatttatgt aaatagtgct ccttctcttt agtatgtttg ctttgggggt agaaaaatgg     2160

ttttaacaaa cactggtttc catcaaatga atgatgtctt ctccatcctg tggagacaag     2220

aatctgctag aaggatatgt gctaagttcc ttataagaga taatggtgct ctgcctatgc     2280

cagcttggca cccgaagatg tgtgagtgga cgtgaggctg agtattacct tagtattttt     2340

ctctgggtct ttggaaaacc atagtcaatt tttagaacat attgctttca ttccccataa     2400

actcttcaca catgataact gtttaagctt tgaaaacaca tactgaagta ttgtgagctt     2460

aaaaaaactt tttaaatatt tgcatagttt tgaggtgaat ttgtttcctt acagatctct     2520

cctaatcatt gagatgtata tttcaaaaga ggaaatttta catgttgtcc aaaacagcct     2580

tgctagtaac tggtgaattt tggtattaac tattattaaa gtctttaaac gacacaggta     2640

cctaaagatc accttaatgt ggcaatttgt gatggtgtag ctagctgatt gtgaaaactg     2700

ttcctttaaa gtcgcttctt gcatgttcgg tgttagtcat ccagctcagg cttgtgttgc     2760

agctgacaat ctaggaaaga cggccttaga gagtggtgca ggccccacac tgacggactg     2820

ccttagaaac ccgacttcct ctagactttg aaccgccaga cttttctctt gtttagaaaa     2880

caaacttata tttaatgtac ttactactta aaactccaga cagagatata atgtagaagg     2940

caaatattgg ccaatttttt cctcttttta agtggaagac aaatgaacgg gatttttaaa     3000

gtgcttttaa agtgcatgaa tggttaataa atcagtatga attgtaagcc ttcatcttac     3060

atccaagtcc ttagttggtt agggtttctt ttctttcttt tttaaagagt gtcaattacc     3120

ttttgaacct gtgaaaattt gatagttgtt aacagtctga tggtcctaat tctttctttt     3180

cattctagaa atgaatgtgg ttgtaatcat gttcctaatt cttgggacaa cctgcaagac     3240

agtgagacag tttaaaaatt acctttcatg ttgaaaaagt ctgaaacaga gaacccaatg     3300

atatttaaaa taaatgctac ataaaactct ttttaaaatt ttgattttaa cttaattaaa     3360

acaatgtcat aaatatgctt tttgattttg ttactgcttt taatattaaa gtaatagaat     3420

attgaagcaa tattgtctag cactctgctg gacattaagt ccgcgggagg agaagtgaac     3480

aggaatcgat tctttgtctt ttaactgccc ttagttagga gatgttaaaa tacttggcac     3540

ctctggttat atgtatgtta tgtgtgttct cccccctaaa atttctaagc acatttattc     3600

acttttaaaa tgaatcttta aaagattata gttagtagtt atagttaata ttctatttac     3660

ttggaaaaat gtgaataaat ggatcttcaa aagattcatt ttaaaaatga ataaatgtat     3720

aataggctat aggtgatctt acttgcgtat taggtaggag gcacatattt ataccatttc     3780

atatgtaata tctttgtcat tgtgtttcat cgaagatcaa ttgctagcaa cttgaagggt     3840

atttatactt gggtcacttg aactcagctg actaaattgt aagaacgaga gcaagcaaga     3900

tggctgttat tggaagccat aacttccaga agataattct gcacaattcg taagttaaaa     3960

aaaatctgta gggtcttcca ctatcctttt tcaggttgat aatgctgttc tgggcacaca     4020

ctttgtaaat ggaatgttat ggtacagtcg cctctcagta tccatggggc attggttcca     4080

ggcctccctt aggatgccaa actccatgga tactcaaacc ccttctataa aatggtgtag     4140

tatttgcata tatcctagac acatcctcct gtatgcttta aatcatctct agattactta     4200

aaatacctaa tacaatgtaa atgctctgta aatagttgtt atactatatt gtttagggaa     4260

taatgacaag gaaaaaaaag cctgtacatg ttcagcacaa gtgaaaccat cctttttgcc     4320

cccaaatatt ttcaatttgt atttggttga atccatggat gcagaactca cggatacaga     4380

gggccgactg tactttcttt aaagtgttca aaagtattac tagcaaagag gaggaggagc     4440

aaagcatata tcagaagtaa aacaattttt cttgttgact gctttggtaa aaaacagttt     4500

gatggatagt tttacatttc actggactag ataaaaaatg gtgctaatat ttatgtagct     4560

tgatgctata gttgctttgg tatcaaactt aatacctaac ccatataaga tccttattat     4620

ataattttgt gatcagtaaa atgatatttt aaagagtgat cttaaaaata tgacctggtc     4680

attgcacaac gtttgcattt gaaatgaatt tgtgtactat agggtggata tggagttatt     4740

cagtgcaagt gtgtgcttaa tatcaaaccc tatgcaagga gctatgtcta gatttttggt     4800

ccaaatttgc ctccttcaag cctactagtg tgagatggaa aaaaatcgat tgctctttta     4860

atattatttc cattttgaaa ttctcgacac ttgaatgaag gcagtagagg cctctttttg     4920

gatttctctt ctaataacaa aactttattt agggaaggtt tccctgtgct atcgtaagtt     4980

tgttttgagc actgcattca ctttaaaatt ctggaggaac aaaggctggg cacataatca     5040

caaagcccag gccacacaat aattcggggt tgtattttct aagaactatg tattgttttt     5100

agcttatagt taatattgta tttacttgga aaaatgtgaa taaagttaat taacatt        5157


<210> 567
<211> 5272
<212> DNA
<213> Homo sapiens

<400> 567
cgccccgggc gccggctgcg tcccggcctc ctcctcctct tcctccgccc tccttggctg       60

ggaaagtggg aggcggcggc ggcggcgtgg tgtgtgtgcg cgcgtgaggg gggcagcaga      120

gaggagtctc ccggtgccgc cgcggcgtca gagacactgc gagcggcgag cgcggtgggg      180

ccgcatctgc atcagccgcc gcagccgctg cggggccgcg aacaaagagg aggagccgag      240

gcgcgagagc aaagtctgaa atggatgtta catgagtcat tttaagggat gcacacaact      300

atgaacattt ctgaagattt tttctcagta aagtagataa agatggatga atcagccttg      360

ttggatcttt tggagtgtcc ggtgtgtcta gagcgccttg atgcttctgc gaaggtcttg      420

ccttgccagc atacgttttg caagcgatgt ttgctgggga tcgtaggttc tcgaaatgaa      480

ctcagatgtc ccgagtgcag gactcttgtt ggctcgggtg tcgaggagct tcccagtaac      540

atcttgctgg tcagacttct ggatggcatc aaacagaggc cttggaaacc tggtcctggt      600

gggggaagtg ggaccaactg cacaaatgca ttaaggtctc agagcagcac tgtggctaat      660

tgtagctcaa aagatctgca gagctcccag ggcggacagc agcctcgggt gcaatcctgg      720

agccccccag tgaggggtat acctcagtta ccatgtgcca aagcattata caactatgaa      780

ggaaaagagc ctggagacct taaattcagc aaaggtgaca tcatcatttt gcgaagacaa      840

gtggatgaaa attggtacca tggggaagtc aatggaatcc atggcttttt ccccaccaac      900

tttgtgcaga ttattaaacc gttacctcag cccccacctc agtgcaaagc actttatgac      960

tttgaagtga aagacaagga agcagacaaa gattgccttc catttgcaaa ggatgatgtt     1020

ctgactgtga tccgaagagt ggatgaaaac tgggctgaag gaatgctggc agacaaaata     1080

ggaatatttc caatttcata tgttgagttt aactcggctg ctaagcagct gatagaatgg     1140

gataagcctc ctgtgccagg agttgatgct ggagaatgtt cctcggcagc agcccagagc     1200

agcactgccc caaagcactc cgacaccaag aagaacacca aaaagcggca ctccttcact     1260

tccctcacta tggccaacaa gtcctcccag gcatcccaga accgccactc catggagatc     1320

agcccccctg tcctcatcag ctccagcaac cccactgctg ctgcacggat cagcgagctg     1380

tctgggctct cctgcagtgc cccttctcag gttcatataa gtaccaccgg gttaattgtg     1440

accccgcccc caagcagccc agtgacaact ggcccctcgt ttactttccc atcagatgtt     1500

ccctaccaag ctgcccttgg aactttgaat cctcctcttc caccaccccc tctcctggct     1560

gccactgtcc ttgcctccac accaccaggc gccaccgccg ctgctgctgc tgctggaatg     1620

ggaccgaggc ccatggcagg atccactgac cagattgcac atttacggcc gcagactcgc     1680

cccagtgtgt atgttgctat atatccatac actcctcgga aagaggatga actagagctg     1740

agaaaagggg agatgttttt agtgtttgag cgctgccagg atggctggtt caaagggaca     1800

tccatgcata ccagcaagat aggggttttc cctggcaatt atgtggcacc agtcacaagg     1860

gcggtgacaa atgcttccca agctaaagtc cctatgtcta cagctggcca gacaagtcgg     1920

ggagtgacca tggtcagtcc ttccacggca ggagggcctg cccagaagct ccagggaaat     1980

ggcgtggctg ggagtcccag tgttgtcccc gcagctgtgg tatcagcagc tcacatccag     2040

acaagtcctc aggctaaggt cttgttgcac atgacggggc aaatgacagt caaccaggcc     2100

cgcaatgctg tgaggacagt tgcagcgcac aaccaggaac gccccacggc agcagtgaca     2160

cccatccagg tacagaatgc cgccggcctc agccctgcat ctgtgggcct gtcccatcac     2220

tcgctggcct ccccacaacc tgcgcctctg atgccaggct cagccacgca cactgctgcc     2280

atcagtatca gtcgagccag tgcccctctg gcctgtgcag cagctgctcc actgacttcc     2340

ccaagcatca ccagtgcttc tctggaggct gagcccagtg gccggatagt gaccgttctc     2400

cctggactcc ccacatctcc tgacagtgct tcatcagctt gtgggaacag ttcagcaacc     2460

aaaccagaca aggatagcaa aaaagaaaaa aagggtttgt tgaagttgct ttctggcgcc     2520

tccactaaac ggaagccccg cgtgtctcct ccagcatcgc ccaccctaga agtggagctg     2580

ggcagtgcag agcttcctct ccagggagcg gtggggcccg aactgccacc aggaggtggc     2640

catggcaggg caggctcctg ccctgtggac ggggacggac cggtcacgac tgcagtggca     2700

ggagcagccc tggcccagga tgcttttcat aggaaggcaa gttccctgga ctccgcagtt     2760

cccatcgctc cacctcctcg ccaggcctgt tcctccctgg gtcctgtctt gaatgagtct     2820

agacctgtcg tttgtgaaag gcacagggtg gtggtttcct atcctcctca gagtgaggca     2880

gaacttgaac ttaaagaagg agatattgtg tttgttcata aaaaacgaga ggatggctgg     2940

ttcaaaggca cattacaacg taatgggaaa actggccttt tcccaggaag ctttgtggaa     3000

aacatatgag gagactgaca ctgaagaagc ttaaaatcac ttcacacaac aaagtagcac     3060

aaagcagttt aacagaaaga gcacatttgt ggacttccag atggtcagga gatgagcaaa     3120

ggattggtat gtgactctga tgccccagca cagttacccc agcgagcaga atgaagaaga     3180

tgtttgtgtg ggttttgtta gtctggattc ggatgtataa ggtgtgcctt gtactgtctg     3240

atttactaca cagagaaact tttttttttt tttaagatat atgactaaaa tggacaattg     3300

tttacaaggc ttaactaatt tatttgcttt tttaaacttg aacttttcgt ataatagata     3360

cgttctttgg attatgattt taagaaatta ttaatttatg aaatgatagg taaggagaag     3420

ctggattatc tcctgttgag agcaagagat tcgttttgac atagagtgaa tgcattttcc     3480

cctctcctcc tccctgctac cattatattt tggggttatg ttttgcttct ttaagataga     3540

aatcccagtt ctctaatttg gttttcttct ttgggaaacc aaacatacaa atgaatcagt     3600

atcaattagg gcctggggta gagagacaga aacttgagag aagagaagtt agtgattccc     3660

tctctttcta gtttggtagg aatcaccctg aagacctagt cctcaattta attgtgtggg     3720

tttttaattt tcctagaatg aagtgactga aacaatgaga aagaatacag cacaaccctt     3780

gaacaaaatg tatttagaaa tatatttagt tttatagcag aagcagctca attgtttggt     3840

tggaaagtag gggaaattga agttgtagtc actgtctgag aatggctatg aagcgtcatt     3900

tcacatttta ccccaactga cctgcatgcc caggacacaa gtaaaacatt tgtgagatag     3960

tggtggtaag tgatgcactc gtgttaagtc aaaggctata agaaacactg tgaaaagttc     4020

atattcatcc attgtgattc tttccccacg tcttgcatgt attactggat tcccacagta     4080

atatagactg tgcatggtgt gtatatttca ttgcgatttc ctgttaagat gagtttgtac     4140

tcagaattga ccaattcagg aggtgtaaaa ataaacagtg ttctcttctc taccccaaag     4200

ccactactga ccaaggtctc ttcagtgcac tcgctccctc tctggctaag gcatgcatta     4260

gccactacac aagtcattag tgaaagtggt cttttatgtc ctcccagcag acagacatca     4320

aggatgagtt aaccaggaga ctactcctgt gactgtggag ctctggaagg cttggtggga     4380

gtgaatttgc ccacacctta caattgtggc aggatccaga agagcctgtc tttttatatc     4440

cattccttga tgtcattggc ctctcccacc gatttcatta cggtgccacg cagtcatgga     4500

tctgggtagt ccggaaaaca aaaggaggga agacagcctg gtaatgaata agatccttac     4560

cacagttttc tcatgggaaa tacataataa accctttcat cttttttttt ttcctttaag     4620

aattaaaact gggaaataga aacatgaact gaaaagtctt gcaatgacaa gaggtttcat     4680

ggtcttaaaa agatacttta tgtggttgaa gatgaaatca ttcctaaatt aacctttttt     4740

ttaaaaaaaa acaatgtata ttatgttcct gtgtgttgaa tttaaaaaaa aaatacttta     4800

cttggatatt catgtaatat ataaaggttt ggtgaaatga actttagtta ggaaaaagct     4860

ggcatcagct ttcatctgtg taagttgaca ccaatgtgtc ataatattct ttattttggg     4920

aaattagtgt attttataaa aattttaaaa agaaaaaaga ctactacagg ttaagataat     4980

ttttttacct gtcttttctc catattttaa gctatgtgat tgaagtacct ctgttcatag     5040

tttcctggta taaagttggt taaaatttca tctgttaata gatcattagg taatataatg     5100

tatgggtttt ctattggttt tttgcagaca gtagagggag attttgtaac aagggcttgt     5160

tacacagtga tatggtaatg ataaaattgc gatttatcac tccttttcat gttaataatt     5220

tgaggactgg ataaaaggtt tcaagattaa aatttgatgt tcaaaccttt gt             5272


<210> 568
<211> 1888
<212> DNA
<213> Homo sapiens

<400> 568
gccgcccggc gcggagtggc tgccctgcgc ggggacactt agagcccggt gggcgggagg       60

aaggcggcat gccccagacg gtgatcctcc cgggccctgc gccctggggc ttcaggctct      120

cagggggcat agacttcaac cagcctttgg tcatcaccag gattacacca ggaagcaagg      180

cggcagctgc caacctgtgt cctggagatg tcatcctggc tattgacggc tttgggacag      240

agtccatgac tcatgctgat gcgcaggaca ggattaaagc agcagctcac cagctgtgtc      300

tcaaaattga caggggagaa actcacttat ggtctccaca agtatctgaa gatgggaaag      360

cccatccttt caaaatcaac ttagaatcag aaccacagga attcaaaccc attggtaccg      420

cgcacaacag aagggcccag ccttttgttg cagctgcaaa cattgatgac aaaagacagg      480

tagtgagcgc ttcctataac tcgccaattg ggctctattc aactagcaat atacaagatg      540

cgcttcacgg acagctgcgg ggtctcattc ctagctcacc tcaaaagacg ggaactactt      600

tgaacacaag cataatattc ggcccaaacc tttcgtgatc ccgggccgaa gcagtggatg      660

cagcactccc tccgggattg actgtggcag tggacgcagc accccttctt ctgtcagtac      720

tgttagtacc atttgcccag gtgacttgaa agttgcggct aagctggccc ctaacattcc      780

tttggaaatg gaacttcctg gtgtgaagat tgtacatgct cagtttaata cacctatgca      840

gttgtactca gatgacaata ttatggaaac actccagggt caggtttcaa cagccctagg      900

ggaaacacct ttgatgagcg agcccacagc ctcggtgccc cccgagtcgg acgtgtaccg      960

gatgctccac gacaatcgga atgagcccac acagcctcgc cagtcgggct ccttcagagt     1020

gctccaggga atggtggacg atggctctga tgaccgtccg gctggaacgc ggagtgtgag     1080

agctccggtg acgaaagtcc atggcggttc aggcggggca cagaggatgc cgctctgtga     1140

caaatgtggg agtggcatag tcggtgctgt ggtgaaggcg cgggataagt accggcaccc     1200

tgagtgcttc gtgtgtgccg actgcaacct caacctcaag caaaagggct acttcttcat     1260

agaaggggag ctgtactgcg aaacccacgc aagagcccgc acaaagcccc cagagggcta     1320

tgacacggtc actctgtatc ccaaagctta agtctctgca ggcgtggcac gcacgcacgc     1380

acccacccac gcgcacttac acgagaagac attcatggct ttgggcagaa ggattgtgca     1440

gattgtcaac tccaaatcta aagtcaaggc tttagacctt tatcctattg tttattgagg     1500

aaaaggaatg ggaggcaaat gcctgctatg tgaaaaaaac atacacttag ctatgttttg     1560

caactctttt tggggctagc aataatgata tttaaagcaa taattttttg tatgtcatac     1620

tccacaattt acatgtatat tacagccatc aaacacataa acatcaagat atttgaagga     1680

ctctaattgt ctttccttga caagttgatt ttgcaattgt ggtaaatagc aaataacaat     1740

cttgtattct aacataatct gcagttgtct gtatgtgttt taactattac agtgcatgtt     1800

agggagaaat tccctgaatt tctttagttt tgtattcaaa caattatgcc actcgatgca     1860

acaaacataa taaatacata aaagattt                                        1888


<210> 569
<211> 1714
<212> DNA
<213> Homo sapiens

<400> 569
caggacgccg cccggcgcgg agtggctgcc ctgcgcgggg acacttagag cccggtgggc       60

gggaggaagg cggcatgccc cagacggtga tcctcccggg ccctgcgccc tggggcttca      120

ggctctcagg gggcatagac ttcaaccagc ctttggtcat caccaggatt acaccaggaa      180

gcaaggcggc agctgccaac ctgtgtcctg gagatgtcat cctggctatt gacggctttg      240

ggacagagtc catgactcat gctgatgcgc aggacaggat taaagcagca gctcaccagc      300

tgtgtctcaa aattgacagg ggagaaactc acttatggtc tccacaagta tctgaagatg      360

ggaaagccca tcctttcaaa atcaacttag aatcagaacc acaggacggg aactactttg      420

aacacaagca taatattcgg cccaaacctt tcgtgatccc gggccgaagc agtggatgca      480

gcactccctc cgggattgac tgtggcagtg gacgcagcac cccttcttct gtcagtactg      540

ttagtaccat ttgcccaggt gacttgaaag ttgcggctaa gctggcccct aacattcctt      600

tggaaatgga acttcctggt gtgaagattg tacatgctca gtttaataca cctatgcagt      660

tgtactcaga tgacaatatt atggaaacac tccagggtca ggtttcaaca gccctagggg      720

aaacaccttt gatgagcgag cccacagcct cggtgccccc cgagtcggac gtgtaccgga      780

tgctccacga caatcggaat gagcccacac agcctcgcca gtcgggctcc ttcagagtgc      840

tccagggaat ggtggacgat ggctctgatg accgtccggc tggaacgcgg agtgtgagag      900

ctccggtgac gaaagtccat ggcggttcag gcggggcaca gaggatgccg ctctgtgaca      960

aatgtgggag tggcatagtc ggtgctgtgg tgaaggcgcg ggataagtac cggcaccctg     1020

agtgcttcgt gtgtgccgac tgcaacctca acctcaagca aaagggctac ttcttcatag     1080

aaggggagct gtactgcgaa acccacgcaa gagcccgcac aaagccccca gagggctatg     1140

acacggtcac tctgtatccc aaagcttaag tctctgcagg cgtggcacgc acgcacgcac     1200

ccacccacgc gcacttacac gagaagacat tcatggcttt gggcagaagg attgtgcaga     1260

ttgtcaactc caaatctaaa gtcaaggctt tagaccttta tcctattgtt tattgaggaa     1320

aaggaatggg aggcaaatgc ctgctatgtg aaaaaaacat acacttagct atgttttgca     1380

actctttttg gggctagcaa taatgatatt taaagcaata attttttgta tgtcatactc     1440

cacaatttac atgtatatta cagccatcaa acacataaac atcaagatat ttgaaggact     1500

ctaattgtct ttccttgaca agttgatttt gcaattgtgg taaatagcaa ataacaatct     1560

tgtattctaa cataatctgc agttgtctgt atgtgtttta actattacag tgcatgttag     1620

ggagaaattc cctgaatttc tttagttttg tattcaaaca attatgccac tcgatgcaac     1680

aaacataata aatacataaa agatttaaaa aata                                 1714


<210> 570
<211> 1672
<212> DNA
<213> Homo sapiens

<400> 570
cgcttccaaa gttggagctc tccggggtgg gagggggcgg ggaggacggc ggggcggtga       60

cgtcaccccc agcggggata aagcgccccc gcccgggtcg gggccaggac gccgcccggc      120

gcggagtggc tgccctgcgc ggggacactt agagcccggt gggcgggagg aaggcggcat      180

gccccagacg gtgatcctcc cgggccctgc gccctggggc ttcaggctct cagggggcat      240

agacttcaac cagcctttgg tcatcaccag gattacacca ggaagcaagg cggcagctgc      300

caacctgtgt cctggagatg tcatcctggc tattgacggc tttgggacag agtccatgac      360

tcatgctgat gcgcaggaca ggattaaagc agcagctcac cagctgtgtc tcaaaattga      420

caggggagaa actcacttat ggtctccaca agtatctgaa gatgggaaag cccatccttt      480

caaaatcaac ttagaatcag aaccacagga attcaaaccc attggtaccg cgcacaacag      540

aagggcccag ccttttgttg cagctgcaaa cattgatgac aaaagacagg tagtgagcgc      600

ttcctataac tcgccaattg ggctctattc aactagcaat atacaagatg cgcttcacgg      660

acagctgcgg ggtctcattc ctagctcacc tcaaaacgag cccacagcct cggtgccccc      720

cgagtcggac gtgtaccgga tgctccacga caatcggaat gagcccacac agcctcgcca      780

gtcgggctcc ttcagagtgc tccagggaat ggtggacgat ggctctgatg accgtccggc      840

tggaacgcgg agtgtgagag ctccggtgac gaaagtccat ggcggttcag gcggggcaca      900

gaggatgccg ctctgtgaca aatgtgggag tggcatagtc ggtgctgtgg tgaaggcgcg      960

ggataagtac cggcaccctg agtgcttcgt gtgtgccgac tgcaacctca acctcaagca     1020

aaagggctac ttcttcatag aaggggagct gtactgcgaa acccacgcaa gagcccgcac     1080

aaagccccca gagggctatg acacggtcac tctgtatccc aaagcttaag tctctgcagg     1140

cgtggcacgc acgcacgcac ccacccacgc gcacttacac gagaagacat tcatggcttt     1200

gggcagaagg attgtgcaga ttgtcaactc caaatctaaa gtcaaggctt tagaccttta     1260

tcctattgtt tattgaggaa aaggaatggg aggcaaatgc ctgctatgtg aaaaaaacat     1320

acacttagct atgttttgca actctttttg gggctagcaa taatgatatt taaagcaata     1380

attttttgta tgtcatactc cacaatttac atgtatatta cagccatcaa acacataaac     1440

atcaagatat ttgaaggact ctaattgtct ttccttgaca agttgatttt gcaattgtgg     1500

taaatagcaa ataacaatct tgtattctaa cataatctgc agttgtctgt atgtgtttta     1560

actattacag tgcatgttag ggagaaattc cctgaatttc tttagttttg tattcaaaca     1620

attatgccac tcgatgcaac aaacataata aatacataaa agatttaaaa aa             1672


<210> 571
<211> 5996
<212> DNA
<213> Homo sapiens

<400> 571
tccttttatt gtggatgaac accacgtaca tgccgtaaat gctccctagg ctggctgcgg       60

ctacaaggca gacccgggag ctgagaatag aggaatacct gcccaagcaa ctcattctgc      120

acagcagccg acaagacagc gattttcctg tgctggaatg tgcccatcca aagacacttg      180

gattggactt aatcttaaac ctctggagtt caagaccttt taaaaagggc taaataaaca      240

atctctacat gtaaaaggcc actgactcct acttcctctg tatagagcaa ctgttgaact      300

cagctgcctg tagggcgtga ttctcagtca ccagactcag cttggagatc ttacaatgat      360

ggcaatcagg agacactgaa cggagatgct acatattcct ctcttgcagc aaaaggtttt      420

agaagcgttc gaccaaacct acaagataaa agatcaccaa ctcagagcca gataacagtg      480

aatggaaact caggaggtgc cgtgagtccc atgagttact atcagaggcc gttttccccc      540

tcggcatatt ctctcccagc ctcactcaac tccagcattg tcatgcagca cggcacatcc      600

ctcgattcca cagacacata tccccagcat gcgcagtctc tggatggcac caccagcagc      660

tctatccccc tgtaccgatc ctcagaggaa gagaagagag tgacagtcat caaagccccg      720

cattacccag ggatcgggcc cgtggatgaa tccggaatcc ccacagcaat tagaacgaca      780

gtcgaccggc ccaaggactg gtacaagacg atgtttaagc aaattcacat ggtgcacaag      840

ccggatgatg acacagacat gtataatact ccttatacat acaatgcagg tctgtacaac      900

ccaccctaca gtgctcagtc acaccctgct gcaaagaccc aaacctacag acctctttcc      960

aaaagccact ccgacaacag ccccaatgcc tttaaggatg cgtcctcccc agtgcctccc     1020

ccacatgttc cacctccagt cccgccgctt cgaccaagag atcggtcttc aacagaaaag     1080

catgactggg atcctccaga cagaaaagtg gacacaagaa aatttcggtc tgagccaagg     1140

agtatttttg aatatgaacc tggcaagtca tcaattcttc agcatgaaag accagcctcc     1200

ttgtatcagt cctctataga cagaagcctg gaaagaccca tgagttctgc aagcatggcc     1260

agtgacttca ggaagcggag gaagagcgag cctgcagtgg gtccaccacg gggcttggga     1320

gatcaaagtg cgagcaggac tagcccaggc cgagtggacc tcccaggatc aagcaccact     1380

cttacaaagt ctttcactag ctcttctcct tcttccccat caagagcaaa aggtggggat     1440

gatagcaaaa tatgtccatc cctttgcagt tactcagggc tcaacggcaa cccctccagt     1500

gagttagatt actgtagcac ttacagacag cacttggatg tccctcggga ctcaccaaga     1560

gccattagtt tcaagaacgg ctggcaaatg gcccggcaaa acgcagaaat ctggagcagc     1620

acggaagaaa ccgtctctcc caaaatcaaa tcccggagct gtgacgatct cctaaacgac     1680

gactgcgata gcttcccgga cccgaaagtc aagtcggaaa gcatgggctc cctgttatgt     1740

gaggaggact ccaaggagag ctgccccatg gcgtgggggt ccccctacgt cccggaggtt     1800

cgcagtaacg gcagatcaag gatcagacac aggtcagccc gcaacgcccc ggggttcctg     1860

aagatgtaca agaaaatgca ccgcatcaac cgcaaggacc tgatgaactc cgaggtgatc     1920

tgctccgtga agtccaggat tctgcagtac gagagcgagc agcagcacaa ggacctgctg     1980

cgcgcctgga gccagtgctc cacggaggag gtgccccggg acatggtgcc cacacgcatc     2040

tccgaattcg aaaagctgat ccagaagtcc aaatccatgc caaatttagg ggatgacatg     2100

ctgtctcccg taaccctaga accaccgcaa aatggcctat gtcccaagag gcggttttcc     2160

attgagtatt tgctggagga agaaaatcaa agcggccccc ccgctcgggg ccggcgaggc     2220

tgccagtcta acgccctggt gcccattcac attgaagtca ccagcgatga gcagccccga     2280

gcacacgtgg agttttccga cagcgaccag gacggggttg tgtccgacca cagtgactac     2340

attcacctag aggggtcatc cttctgcagt gaaagtgact ttgatcactt ttccttcaca     2400

tcctccgaaa gcttttacgg atccagccac caccaccacc atcaccacca ccaccaccac     2460

cgccacctca tcagctcctg caaaggcagg tgcccggcct cctacactcg atttaccaca     2520

atgttaaaac acgaaagagc cagacacgaa aacaccgagg agcccagaag gcaagaaatg     2580

gaccctggcc tttctaaact tgcttttcta gtcagtcctg tgcctttccg gaggaaaaaa     2640

aattcggctc ctaagaaaca gactgaaaag gcaaaatgta aagcatctgt gtttgaggct     2700

ctggactctg cccttaaaga catctgtgac caaattaaag ctgaaaagaa aagggggagc     2760

ttgccggaca acagcatcct gcaccgcctc atcagtgagc tgctgccaga tgttcccgag     2820

aggaactcat ccctgagagc gctgaggagg agccccctgc accagcctct ccacccactg     2880

cctcccgatg gtgctattca ttgtccaccc taccagaatg actgcgggag aatgccccgc     2940

agtgcctctt tccaagacgt ggacacagcc aacagcagct gccaccacca agaccgtggc     3000

ggtgcactcc aagaccgtga gtcccctaga agttactcat ccactttgac tgacatgggg     3060

agaagtgcac caagggaaag aagaggaact ccagaaaaag agaaattgcc tgcaaaagct     3120

gtttatgatt ttaaggctca gacatctaag gagttgtcat ttaagaaagg agatactgtc     3180

tacatcctca ggaaaattga tcaaaattgg tatgagggag aacaccacgg gagagtgggc     3240

atcttcccga tctcatacgt agagaaactc acacctcctg agaaagcaca gcctgcaaga     3300

ccacctccgc cagcccagcc cggagaaatc ggagaagcta tagccaaata caacttcaac     3360

gcagacacaa atgtggagct gtcactgaga aagggagata gagttattct tcttaaaaga     3420

gttgatcaaa actggtatga aggtaaaatc ccaggaacca acagacaagg catcttccct     3480

gtttcctatg tggaggtcgt caagaagaac acaaaaggtg ctgaggacta ccctgaccct     3540

ccaatacccc acagctattc tagtgatagg attcacagct tgagctcaaa taagccacag     3600

cgtcctgtgt ttactcatga aaatattcaa ggtggggggg aaccgtttca ggctctgtat     3660

aactatactc ccaggaatga agatgagctg gagctcagag aaagtgatgt cattgatgtc     3720

atggaaaagt gtgatgacgg ctggtttgtg gggacctcaa gaagaaccaa attctttggt     3780

actttccccg gaaactacgt caagaggctg tgaattgcgc tccctccttc tgtagaggcc     3840

gcctgccagc catgcacctg cgtcaacgcg cctgaaacac cccgcgggcc tcccgttgtc     3900

atgccttacg gtttccaatg cgccgtcacc atctccacct gccaccaaac caccagcaga     3960

gtagccgccg ctgctgtgag cctggggacg acatggcagg ctggtccccc tccgtgaaag     4020

tgtggattcc tacttcctgc tctaagcttt gacacgtcaa aatgtgggat cagaaagaaa     4080

aaaatcatga tatttaaaaa tggtcaaata tttgaggcaa aaaaaaaaaa aaaaagtgtc     4140

tccaggaggc tgtccagcct cgtggctcca tttcaacatc tccccccagg cgatgttctc     4200

ccccaagacg accagaaaat tgtttattgg ggaatgctgt ggtttgcatt ttcatattct     4260

tcgcttggca gtgtgtattc ttttcacaag tttgcctagt gtcttggttt acacaatatg     4320

acaactgtaa ctgtacttta gctattgttt gcctgcacat acatgttgta atatgcacag     4380

tgattacaac ctttaaagca agaggaggcg agttaatttg gatgagtgtg attttgctga     4440

ttgaatgtga gttttcaaat aggagtcttt ttctgcaatt tgtttgcatt ttttagaagt     4500

gcaaacagta agtaaataaa agccttcggt aataatcatg acaatacaag aggctgagct     4560

aggctacagg ggaaaactat tgtgttgtaa agttgcatcg ctattttata ttaaaatgta     4620

atgatcagca tcatgaacaa tgagctctta gtgttttatt tatctgaaaa aatgtaagta     4680

aaagcagtgt tagtgagagg tgcaaagaat tattctaaca gacacctgaa agtatctgta     4740

agcaatacta gtaggtaaga tttcactgtg tgtacacata cacatttgag attgtatgag     4800

aacatataat ccatatgata tgttgtacat tttatggaaa tgtaatagaa tctcacacat     4860

tattttatag aaatagagta cagaagcatc acaagtatta aagttggttt tagcaaggat     4920

taggattact acaattattt ttactataat aattattttt cttctatgga actcagaatc     4980

ctggctacat ttgaggacag gaatatgttg agcctgattt tcctggtgtg tgtaaaatat     5040

ttcctaggaa taaattaggc actttttaga agcaatgtta aatcattcag gttttatttt     5100

ctgccctgaa gcagaaattt aaaaaatgat attgggacct ggaaggttta atatggttca     5160

cagtgcctga attacacctg ctccgaaaac tagctttgta tttcttatga ctttgcataa     5220

gaactgttca tctttggatc ttgagcacct tacagataaa actttttatg gcatctcttt     5280

catggacagt gatattgatc ttttcacaat gtacgtagcc tctagaattt tgtacatatg     5340

tttgctcttt ttttgtacag actagttgtt gagaaaacag gggcgtttcc taatttggtc     5400

tttatcctgc gacaacactt tcagcagact agcctctcct tatctcacag atcacaagca     5460

cccctagata gtgtgattct gtcagatagc atttatgcaa aaatctatga agttaaaaga     5520

tcgtagaagc caaatgaaat gtacatatct actgactgat gacaagggaa tttcattagg     5580

aagaaggtaa agaaacatcg ttgagtagcc taccttgatt tctgtcaagt tcataaccag     5640

cttcatattt taaaggcttc aggtttgaaa ttaagtcaac tgcatgcagc tttgctgata     5700

aatgaataat tctctttgat gccatttatg agaaaagact tcaatatctg ttgcctgtca     5760

tatttaagaa aaattactgt ttctactctc tgtatctgat tttaaaagaa aaaactattc     5820

atacctggct tccaggtaat tgactttgaa ttcttacaag caaaggtcat tgtgtttttc     5880

ttgaatagac atctaataaa ttttgcttgg aagtatactt cagtttttct tcttgacatt     5940

tatctttata aaaattgtgt attttattcc aacttgttaa actaagagaa aatgca         5996


<210> 572
<211> 5720
<212> DNA
<213> Homo sapiens

<400> 572
caaaaccacc tgtcgctccc aagccaaaga ctaccagtcc actgacgcca gtgaccgcgc       60

ccaaattccc ttcctcagcc aggcccgaga gtcttcacag tccaaactcc atgttcaggg      120

gtccgaagcc ccccattgcc cccaagccca ggctgactgc cccaaacgag tggagagcca      180

gtgtgtacct gaatgacagc ttgaacaaat gcagcaacgg gcggctgccc tgtgtagaca      240

gggggcttga tgaggggccc cggtccatcc caaagtgctc tgagtcggag accgacgagg      300

attacatcgt ggtccccagg gttccgctga gggaggatga acccaaggac gagggcagtg      360

tggggaacaa agccctggtg tctcccgagt cctctgcgga agaggaagag gagcgtgaag      420

agggaggcga ggcatgtggc ctggagggta caggagctgg tgaggattca gtggcccctg      480

ctgctccggg tgcaggagcg ctgagcaggg agggtgagga aggcacagac cttgctcttg      540

aggatgaagg ggagggctgc gctgatgagc cagggacact ggagcaggtg tccagaagtg      600

aggaggaaga gaagctagtg cagccacaca gggagtgcag cctggaggac agtgggcctt      660

gggctggaga gggggtcttc cagagcgacc tcctcctgcc tcacatccat ggagaggacc      720

aggagccccc cgacaccccc ggggaggcag aggaggatga tgaggaaggc tgtgccagca      780

cagacccagc aggggcagat gagggttcgg gtcctgacag gcccacggag gacatgggac      840

aggatgctga ggacaccagt gaggagcccc ctgagaagga ggagctggcc ggggtccagg      900

aggcagagac agccacagac tgccctgaag ttcttgagga gggatgtgaa gaggccacgg      960

gtgtcacagg tggggaacag gttgacctca gtgaaccacc tgaccacgag aagaaaacca     1020

accaagaagt ggcagccgcc accctggagg accatgcaca ggatgagtcc gccgaggaga     1080

gctgccagat tgtccctttt gagaatgact gcatggagga cttcgtgact tccctcacag     1140

gaagccccta tgagttcttc ccaactgaga gcacctcttt ttgcagcgag agctgttctc     1200

ctctttctga atcagcgaaa ggtttagaat cagagcaggc accaaagctg gggctgcgtg     1260

cggaggagaa ccccatggtg ggggctttgt gtggccagtg tggctcccta cagggtggag     1320

cggccgaggg tcccgcagcc cctgatgtgg tggtcgtgct ggaggaggag gccttggatg     1380

atgcactggc caacccctat gtgatgggag tgggcctgcc cggtcaggcg gcccctggag     1440

aaggagggca ggctgcatcg gacgccctgg gtggttatgg ctcgaaagaa gaattgaact     1500

gtgaggcaga gggtggcctg gttcccgcgg acaggaagaa caccagcacg agggtccggc     1560

cccactctgg gaaggtggcc ggctatgtcc cagaaaccgt ccctgaagaa accggacctg     1620

aggcgggctc gtcagcccct ggcattggag gtgccgcaga ggaggtggga aagacgcttt     1680

tgtcattgga ggggaagccc ttggaagcca gcagggcctt gccagcaaag cccagggcct     1740

ttactttata ccctcggtcg ttctccgtgg aaggccgaga gattccagtg tccgtgtacc     1800

aggagcctga ggggtcaggg ttggatgacc acaggataaa gaggaaagag gacaatctct     1860

ctctgtcgtg tgtaattggc tcctctggga gtttctccca gagaaaccac cttccgtcca     1920

gcggcacctc cacgccttct tccatggtcg acatcccacc tcctttcgac ctggcctgca     1980

tcaccaagaa gcccatcaca aagagctctc cctcactcct gatcgagagc gactccccgg     2040

acaagtacaa gaagaagaag tcatccttta agcgcttcct ggcactgacg tttaagaaga     2100

agacggagaa caaattgcat gtggatgtga acgtgtcttc ctctaggtcc tcttcagagt     2160

ccagctacca cgggccttcc aggattctgg aagttgaccg gagaagcctc agcaactccc     2220

ctcagcttaa gtctcggact gggaagctcc gggcttctga atccccctcc tccctcatct     2280

tttatagaga tggcaagagg aaaggtgtcc ccttcagcag gacggtgtcc agagtggagt     2340

cctttgaaga ccgctcccgg ccgcccttcc tgcccttgcc actgaccaag ccacggtcca     2400

tctccttccc cagcgctgac acttcagact atgagaacat tccagccatg aactcggact     2460

atgagaatat ccagattcca ccccggagac ctgccagggc tggcgcgttc acgaagctgt     2520

ttgaagatca gagcagagcc ctgtccacag caaacgaaaa tgatggctac gtggacatga     2580

gcagcttcaa cgcctttgag agcaaacagc agagtgcaga ccaggacgca gaaagcgcct     2640

acacagagcc ctacaaagtc tgtcccatct cgtcggcagc ccccaaagag gaccttacgt     2700

cggatgaaga gcagagaagc tcggaggagg aggacagtgc ttcaagagac cccagtgtca     2760

cccacaaggt ggaaggacag tccagagccc ttgtcatcgc acaggaactg ctatcttcag     2820

agaaagcata cgtggagatg ctccagcact taaatctgga tttccatgga gctgtcatga     2880

gggccttgga tgacatggac catgaaggca gagacacatt ggcccgggag gagctgaggc     2940

agggcctgag tgaactccca gccatccacg accttcatca aggcatcctg gaggagctgg     3000

aggaaaggct gtcaaattgg gagagccagc agaaggtagc tgacgtcttc ctggcccggg     3060

agcaggggtt tgatcaccac gccactcaca tcctgcagtt cgacaggtac ctaggtctgc     3120

tcagtgagaa ttgcctccac tctccccggc tggcagctgc tgtccgtgaa tttgagcaga     3180

gtgtacaagg aggcagccag actgcgaagc atcggctgct gcgggtggtt caacgcctct     3240

tccagtacca agtgctcctc acagactatt taaacaacct ttgtccggac tccgccgagt     3300

acgacaacac acagggtgca ctgagcctca tctccaaagt cacagaccgt gccaacgaca     3360

gcatggagca aggggaaaac ctgcagaagc tggtccacat tgagcacagc gtccggggcc     3420

aaggggatct cctccagcca ggaagggagt ttctgaagga agggacgctg atgaaagtaa     3480

cagggaaaaa cagacggccc cggcacctat ttctgatgaa cgatgtgctc ctgtacacct     3540

atccccagaa ggatgggaag taccggctga agaacacatt ggctgtggcc aacatgaagg     3600

tcagccgccc tgtgatggag aaagtgccct acgctctaaa gattgagact tccgagtcct     3660

gcctgatgct gtctgcgagc tcctgtgcag agagggacga gtggtatggc tgtctgagca     3720

gagccctccc tgaggactac aaggcccagg cgctggctgc attccaccat agcgtggaga     3780

tacgagagag gctgggggtt agccttgggg agaggccccc caccctggtg cctgtcacac     3840

acgtcatgat gtgcatgaac tgcggctgcg acttctccct caccctgcgg cgtcatcact     3900

gtcacgcctg tggcaagatc gtgtgccgga actgttcgcg gaacaagtac ccgctgaagt     3960

acctgaagga caggatggcc aaggtctgcg acggctgctt cggggagctg aagaagcggg     4020

gcagggctgt cccgggcctg atgagagagc ggcctgtgag catgagcttc ccgctgtctt     4080

caccccgctt ctcgggcagt gccttttcat ccgtcttcca gagcattaac ccctcgacct     4140

tcaagaagca gaagaaagtc ccttcagccc tgacagaggt ggctgcctct ggagagggct     4200

ctgccatcag tggctatctc agccggtgta agaggggcaa gcggcactgg aagaagctct     4260

ggtttgtcat caaaggcaaa gttctctaca cctacatggc cagtgaggac aaagtggcct     4320

tggagagtat gcctctgcta ggcttcacca ttgctccaga aaaggaagag ggcagcagtg     4380

aagtaggacc tatttttcac ctttaccaca agaaaaccct attttatagc ttcaaagcag     4440

aagataccaa ttcagctcag aggtggatcg aggccatgga agatgcgagt gtgttatagc     4500

agttatcaag catgtggact tgtaacaaat tcttaggtca atatgtgaat gcttttagaa     4560

gctaagctgt ggctcaactc atccggacac acacctggat tcagcaatga ggcctgacct     4620

tttttgctat aaccgcccca ccactcccct gcccttgcca acatcttcat gaatggaatc     4680

cttaagggat atttatggac ctctcctttt ctgtgttttc cacccctacc cccacccgcc     4740

acccagtaat aaactatttc cttaccccgc agtgagttaa aatttagtaa gatgaagatg     4800

tggaaaccaa tgaaaagtac atttagaaat gcaggctttt tagtagaaag aagctcttac     4860

agtttttact catgataaat cttatcacct ttcaaaaatt gattgtggtg cctcaggtga     4920

aatgagaagc tatcagtaac agctactctc atcgaaagca ctttattatt ttacggagct     4980

gcaacctcca attttgtgtt ttctaagtga tttacttaag tcaataacag atggaatcct     5040

gtggactaat gtgccaccag ttttctaaca agggtgtaca taaaatggat ttgtgcagac     5100

ctggctgtgg cttgctggtg tgcaagcaca catcacttta gaggggctgc gccccaccag     5160

ataggaaggg gaggattttc tcctccagtc gaccttgtga cctgtatact aacataactt     5220

attaaaggag gggtccctcc tcccccagag cagtcctcaa cactatgtca gtgctggaaa     5280

tgcagccact ggcagatctg gccccccaga cgtcaccgca gggcctctga agagtcaagg     5340

tctgctttaa tttattgtgt gcctttctgt gtttacctca ctcaagctga caacattgtt     5400

tatgggaatc tatccttctt ttagacacac ggtaatcctt gggctgtatt actgaaggct     5460

ttttattttt tgagaggtga aaaaaagaga aaacaagtta gactccaaag gtgaattcct     5520

ggtcttggca gatggctctg ggaacagcga gggagcacag aagtcgtggc ctgaggctgt     5580

tctatgggca cttggggcta aatcgcctcc tgagggtgac tgttgcttat tctgctggac     5640

aggtttttac ataaagcaaa gggcatgtga ggggtgggat tccttgttac tcttactgca     5700

ataaaaatca attgtttgat                                                 5720


<210> 573
<211> 2905
<212> DNA
<213> Homo sapiens

<400> 573
gatgacgcaa accgggaaca gcggctgagc ctgcgcttcg gaagcatgga tgtgcgcctg       60

cgctgcgcta gggcgcggcg ggcggtttga attttgctta cagagtcccg tctcaccatc      120

ctgggcttcc aacggagact gcggtatccg cagctggaga cccagcggcg agtagccttt      180

tgctcccgga cggacttgag aggcttaaag gatggcctcg tcagatctgg aacaattatg      240

ctctcatgtt aatgaaaaga ttggcaatat taagaaaacc ttatcattaa gaaactgtgg      300

ccaggaacct accttgaaaa ctgtattaaa taaaatagga gatgagatca ttgtaataaa      360

tgaacttcta aataaattgg aattggaaat tcagtatcaa gaacaaacca acaattcact      420

caaggaactc tgtgaatctc ttgaagaaga ttacaaagac atagaacatc ttaaagaaaa      480

cgttccttcc catttgcctc aagtaacagt aacccagagc tgtgttaagg gatcagatct      540

tgatcctgaa gaaccaatca aagttgaaga acctgaaccc gtaaagaagc ctcccaaaga      600

gcaaagaagt attaaggaaa tgccatttat aacttgtgat gagttcaatg gtgttccttc      660

gtacatgaaa tcccgcttaa cctataatca aattaatgat gttattaaag aaatcaacaa      720

ggcagtaatt agtaaatata aaatcctaca tcagccaaaa aagtctatga attctgtgac      780

cagaaatctc tatcacagat ttattgatga agaaacgaag gataccaaag gtcgttattt      840

tatagtggaa gctgacataa aggagttcac aactttgaaa gctgacaaga agtttcacgt      900

gttactgaat attttacgac actgccggag gctatcagag gtccgagggg gaggacttac      960

tcgttatgtt ataacctgag tcccttgtga acttttgaac ataccaacag ggtatagagt     1020

atagaggcta tttctataat tttcttatat ataatttttt taacttttaa tcttttttgt     1080

ttcctttttt ttttttttga gacaggatct tgctttgtca cccaggggct tgctttgtca     1140

cgcaggctag agtgcagtgg cgcaaacatg gctcactgca gcctcaacct cccaggctca     1200

agtgatcctc ccacctcagc cccctgaatg gctgggacta caagcgtgcg ccaccatgcc     1260

tggctaattt ttgtattttt tggagagatg gggtttcacc atgttgccta ggctggtctt     1320

gagctcctga gctcaaacaa tccaccctcc tcagcctccc aaagtgctgg gattacaggc     1380

ttgagccacc acacctgacc tattcttgtt tcttataaaa ataaaacttt tttggataaa     1440

gcttatttct tgtttttttc tttttctttt tttttttttt tgagacagtc tcgctctttc     1500

acccaggccg gactgcagcg gcgctatctc ggctcactgc aaactctgcc tcccaggttc     1560

acgccatcct cctgcctcag cctcctgagt agctgggact acaggcacct gccaccacgc     1620

ccagctaatt ttttgtattt ttagtagaga tggggtttca ccgtgttagc caggatggtc     1680

tcgatctcct gacctcatga tccgcccacc tcggcctccc aaagtgctgg gattacaggc     1740

gtgagccacc gcgcccggcc aacttatata ttttcaagat tcacctcctc tcaccaaata     1800

tttaactacc tgctgaatac gcctctgtac taggcacata atggaactaa aaaatgctca     1860

tgtccagttt ttgtgttgag tgaacaatgc tgcagaccct aataagattg ggtacagatc     1920

ggcatgcgcc tgtagtccca gctactcagg agaattgctt gaacctagga ggtggaggtt     1980

gcagtgagcc gagatcgtgc cactgcactc cagtctgggc aacagagcga gactccatct     2040

cagaaaaaaa gaaaaaaaga ctgggtacag atgtgatatt ggaagaaaaa gatcaagctg     2100

atgaggttag gatacccagg ccctttggac ttaaagatca ctagtgtcta aattccatcg     2160

atggcatttc agtctatagg taaacttcct ggaagctgga tttggagaca gtttatcatc     2220

tgattattgg gctttcgtat aggtccttag ggagcagctt acctgaaatg catttagtgt     2280

acaccagtct gtaaacttca acctgtaatg aaagtgtaat aaatgtacat tgagttgatg     2340

tgataatgtg atataataag aaatatatat ttgatcttcc tatctagttc cttgttcaga     2400

gctcctaaaa cccttgtaat ttccaaagtg atggagtaca tcttttgttc tagtatttgg     2460

tctttgaccc cagttcctga cacaaagctc ctaaattcct ttaaatttcc cagtgatagg     2520

agaatttttt gttctaatga ggtcactctt gatgggcacc tggataactc aggatggggg     2580

ctgctcacaa agaccacatc atgattggaa gtttcaaact ttcagtctcc cacctccaga     2640

gaggggagag gggctggaga tttgtgtcaa taatccatca ggcctatgtc aacaagacat     2700

aatccgttaa ctatggagtt cagggagctt cagggttggc aaacattttg atgtgccagg     2760

aaggtgacgc actccagctt tatgaagtca gcaagtcctg tgctcaggat gcttctggac     2820

cttgccccag gtaccccttc atgtggctgt tgttcatctg tatcctttgt agtagcctta     2880

aaataaactg ttaaacacaa gtaaa                                           2905


<210> 574
<211> 5526
<212> DNA
<213> Homo sapiens

<400> 574
ctcctccgcc ccgcgcgccg tccctgcgcc ccgctccgcc cgcgcctctc tcccagcgcc       60

gcgcctcggg cgtaaagagc gcgcccctcg caccgcagcc agtgccgacc gcagcagccc      120

agccccagcc ttcctccgcc tccgcctctc tctcctcctc ctcctccgcc gccggacacg      180

cagccgcagg ccgggaccgg gacgcagctg gggagtcagg gacgcgcgca gccagccctt      240

ccccctccgg ctcccgcacc gccggccgcc tcccctcgcc ctcctactct cccctccctg      300

ctccttcgct ttttcctcct cctcctctcc cggccccggc tgccagcacc atgtccgcag      360

ggggagattt tgggaatcca ctgagaaaat tcaagttggt gttcttgggg gagcagagcg      420

tcgggaagac gtctctgatt acgaggttca tgtacgacag cttcgacaac acataccagg      480

caaccattgg gattgacttc ttgtcaaaaa ccatgtactt ggaggaccgc acggtgcgac      540

tgcagctctg ggacacagct ggtcaggaga ggttccgcag cctgatcccc agctacatcc      600

gggactccac ggtggctgtg gtggtgtacg acatcacaaa tctcaactcc ttccaacaga      660

cctctaagtg gatcgacgac gtcaggacag agaggggcag tgatgttatc atcatgctgg      720

tgggcaacaa gacggacctg gctgataaga ggcagataac catcgaggag ggggagcagc      780

gcgccaaaga actgagcgtc atgttcattg agaccagtgc gaagactggc tacaacgtga      840

agcagctttt tcgacgtgtg gcgtcggctc tacccggaat ggagaatgtc caggagaaaa      900

gcaaagaagg gatgatcgac atcaagctgg acaaacccca ggagcccccg gccagcgagg      960

gcggctgctc ctgctaatgc agagccgacc tgtggcttcc catgacactc cttgcttgtt     1020

gtgttgcttc ctattggcta gcttcctaag gggggaggga accgagttat caagatggga     1080

ggatttttct tttctctctg tctttaggag tagggtggga tggggaggga ggctgggcat     1140

cagggatcac atcactctta acggctgtta cttaaacaac tattttttgg tttggttgta     1200

atatattgta ctttattaag attgccaaaa actgttaaaa tttaaaaaaa atttaaatca     1260

tgtgtataca attttttgcc agataaaaat gtagtcattt ttatttgaaa gatgtgcttt     1320

ttgtttttgt atatttgtaa acttatagag aaccttttcc acacacctcc tccttcctgt     1380

tctctttgaa ccattcatca cctctgcctt cctcctatcc ccagcccaat aaattaaaac     1440

aattaactga gcaaattaat taggcttcag tctggggcca tctggcccca ctctctaggc     1500

cctactccag ttaaatcaaa cattggttga acacatcagc ctctgaaaag gtagctctga     1560

ctcttgtctt tccatggcca gagtgggtcg tcaacctcgt gtggagctga gaccaaggtc     1620

tgtgggctct aggcagcccg gcagcagccc ccagaggaac tgctcccacc tctccttctc     1680

tttccctgaa aagccttgaa gggggttgag ggtacaggca accttgtgtt ctctgtgccc     1740

tcagggactg gcagagcaag aggccatcag aaggacgagg tgctgttggc aattgcagct     1800

gcgtggtgcg tggtttatag actggggtgc catgtgtact tctgaaaata ttttaaccag     1860

cccacccagc agtcagtaca catgcctggg ccaagtctaa gaaactcagt gtgtgatgtt     1920

gggcagtgtg ccatcctgaa gccttcctcc tggatgtcag ggaagctgga ccacctggag     1980

ttgatcctct gtgatgggga ggcggggggg ggggggggtg ttgtctgcag aaccaccacc     2040

ttgaaagatc catgttctta gagcctcagc tgctaatatt gttgagtgct ttctggaaaa     2100

gctgatttgt tgctatgttt tcaccccagt ggcatggcgc agttgaagtc tttgtggaca     2160

tatctttgtg gctactgtgg ctgcgctgtg gtcacctgag gatgtggttc aggtggggtc     2220

tccagaaggc tgcttgcccc cagagagcca tctcttccat ttttgattca ttcctgagaa     2280

tggcttagtc ctgagaatct gcaaagtctc tgaagagaac tctctcttcc cactaagtga     2340

tataacctac ttggccagca ttccaaatag actcagactc actgccctga gcctgcacag     2400

agccaggtgc aatgggcagt gagtctggcc aaaatgtaaa ccccaccctc cctgctgtca     2460

ttggctctcc ctccaggctg ctgctgggca tgtcatagat gggatgaatg accatctggg     2520

gtatggtggg ctgaactcca caaggtcgtt ggaatgaatt ttgaaacttc tcagaaatta     2580

atctgaaatg gcaggcagta agtgcagcag aatctggcag gactgatatt tgtgcagtgg     2640

gcctgccaca caccctctgc ctaggaggct gtatgccaga gctcatctct agcaaggaat     2700

ttatcttcag gtgaagaaga gaggaagcag gatcccactg agcacctctt gcagaaggca     2760

aggaccaatg tttgaacgtg tttcagatgt catgtgttta gtttttatat gtgtgtacat     2820

aattatatat agagatagac ttgtgtatac accttccaca aacacatcct cacggagata     2880

catgtgctca atgtatattc ttgtttctcc tgctctcaag ttggaacttg cattgtgata     2940

agttttggaa attcaaaagt actgcaacgt gttgaaataa gaaatactta atattgtcaa     3000

ataacttgtg attgtcttgc catcaataaa ataatgcata gttgtgttaa actacaggca     3060

aacatagccc acgggaatat ctccaccatt tctctatgta ctttatatgc acgggtgtgc     3120

atgcctgtgt gggccagtgt ccccccacca tgggcacacc cccaagtggt gcttgttgga     3180

agagtgctta cttacctcga gagaatttac aggagtccac atgacagtgt cctgcctggt     3240

tggcagcggg ggccatcacc tgtggcctct gagaccgccc catttacagg aatctgcact     3300

gggtctcagt gaatgaacgt atggtagatt tttattttct tggcactaaa gattagcttt     3360

tttaaaaaaa catcccataa aacagtagaa actcagttcc cttctcaggg gcacacacat     3420

ccaaggcacc gtggactgtg tttccatcct ggcctagagg agcagtaaaa gatagcattt     3480

ggtttgacat ggccttagtg agtcctgcct ttcctagcat gcacacaaca tcctctcttt     3540

gagtttgggt tctccccagc cccttggcct ctgaggctga gggtggcttc ctcccatcct     3600

cccatctcag tggttccatg gcgctccctt cggcacgtgc ggtttccgcc cctcccttcc     3660

tggggtgtgg aaaggcagcc agacctcttt ttcagaagtt gttggttccc tgatttttgt     3720

cttgagcagg caccatccct gtccccttgc ttgcaggtag aattggcaca gagttaaggt     3780

tccataataa actgttaggt gctcttgaag aagatgtcat ggcattgcct cagcacccca     3840

gcaagagcat tgcatctttg ctgaatccag atgggttagc agagggcaaa ttggaggatt     3900

cctttgagga aatgttctca attgagcaat tcagtccctc tccccaaaga ctagacgtga     3960

cctggcagat tagcaggatc ctcttggcct tcttttttgg ggatggtggg agtgaagggg     4020

gtgaatctta aaagcttatc aacaaagctc ctgttctgca ggcatcagga aagttgagtg     4080

taagatggaa aaagcaaaca gcctatttac aagtggaaac acattggttc tgatcactcc     4140

taacttgctg ggtgatcata catacatcaa catgaaggtg tgacatcaga atcatgagca     4200

ccatggctgc agttgtgtga tccaaggcta gttggcttgg tagctgttgg cagcagtttc     4260

ccttggtcag aggcctcctt gctatctatc gctgctctct tcttgtcatc cttaaacatt     4320

cagtcatgtt cccaggtctg aggggagcaa tggccagacc agtttcagta tctctggcaa     4380

cagaaacaag gattgaaatg gtggtagtta agagtgcaga cacatctggg gtgcaacgtc     4440

tgcatcatcc tggtggctag ccagtgcggg gaggccctgc cctgggatac cagttgtgac     4500

aataaaggga tggccctcct ggcttcagca tcctgcaggt agagcagcct cattccttca     4560

caagatggaa ggcaggtgag gatgtcagga tgagatggga ccaggtagcc gaggacagtg     4620

aggcatgtct gagccacttg aggggcagct gaacagaagg atgtctgtgt gcatcaaccg     4680

agcagattgt gcgcacactc gtttccgaac tgcctctccc caaagaatgt gaggcattgt     4740

caccttgtta cagctatgtg aagcagagct gtcacaactt ttcctgtcta caggcaggaa     4800

aaccaggatg gagaagggca acttgcttat taagatcacc cagcaagtta ggagtgatca     4860

gaaccagtga agtttccatt tttcatccat tgctgccctg tgtgtgaaca aatgtgactc     4920

catatttatt acacagcaag gactgctgtg tgtgggtgtg ttcctcagac catctctact     4980

ctttttggtt aggacactag gttcttccca gcatatgagt gagaatattg gtggtatttt     5040

gggctcctct actgcacaag ggccagtccc caagtctact ctgattgatt gtcatgggca     5100

cccacacaga tcaggacacc ctttgaattt ttgtttgaca tgaactattt aggtgttcca     5160

aaaccttggg atctcaatgt gcaaactcct tggactccag acccctgtct ggttggcact     5220

cccagcagtg tgtggtttca tcaggaaatc cttgcagcag gggtttagat ggttccttca     5280

ggaggtggga agcctccata gcattgaagg ccagcctgca tctcgcggtg tgtgtccact     5340

tctcccctca ctttcccctc acccatccct ttaaagtgat tggctgtgag gagcacagag     5400

ggtggcaatt ccatctgtta tgggctcaga agacatagcc gccatgttga tttcacatta     5460

aactgtgtaa aatgtggaaa agactcagca tgttggtcaa acaataaact gtcctaattc     5520

tcaaaa                                                                5526


<210> 575
<211> 3973
<212> DNA
<213> Homo sapiens

<400> 575
aagcagcccg cggaccggca gcaaaggaac gtgcgaacgc gtgacgccgc ccgactggct       60

cgcgctctcc cgtgccccgg cgtcctccgc ccgctcatgg cccgggccgc cgcggacgag      120

cggcgctgag gcgggccgcg tggagacgtg aggcggccgc cgtggccctc acagtcggcg      180

tttcgccgcc tgcccgcggt gcccgcgcac gccggccgcc atcgccttcg cgcctggctg      240

gcgggggcgc tgtcctccca ggccgtccgc gccgctccct ggagctcggc ggagcgcggc      300

agccagggcc ggcggaggcg cgaggagccg ggcgccaccg ccgccgccgc cgccgccgcc      360

gcgggggcca tgaccgtgga gcagaacgtg ctgcagcaga gcgcggcgca gaagcaccag      420

cagacgtttt tgaatcaact gagagaaatt acggggatta atgacaccca gatactacag      480

caagccttga aggatagtaa tggaaacttg gaattagcag tggctttcct tactgcgaag      540

aatgctaaga cccctcagca ggaggagaca acttactacc aaacagcact tcctggcaat      600

gatagataca tcagtgtggg aagccaagca gatacaaatg tgattgatct cactggagat      660

gataaagatg atcttcagag agcaattgcc ttgagtttgg ccgaatcaaa cagggcattc      720

agggagactg gaataactga tgaggaacaa gccattagca gagttcttga agccagcata      780

gcagagaata aagcatgttt gaagaggaca cctacagaag tttggaggga ttctcgaaac      840

ccttatgata gaaaaagaca ggacaaagct cccgttgggc taaagaatgt tggcaatact      900

tgttggttta gtgctgttat tcagtcatta tttaatcttt tggaatttag aagattagtt      960

ctgaattaca agcctccatc aaatgctcaa gatttacccc gaaaccaaaa ggaacatcgg     1020

aatttgcctt ttatgcgtga gctgaggtat ctatttgcac ttcttgttgg taccaaaagg     1080

aagtatgttg atccatcaag agcagttgaa attcttaagg atgctttcaa atcaaatgac     1140

tcacagcagc aagatgtgag tgagtttaca cacaaattat tagattggtt agaagatgcc     1200

ttccaaatga aagctgaaga ggagacggat gaagagaagc caaagaaccc catggtagag     1260

ttgttctatg gcagattcct ggctgtggga gtacttgaag gtaaaaaatt tgaaaacact     1320

gaaatgtttg gtcagtaccc acttcaggtc aatgggttca aagatctgca tgagtgccta     1380

gaagctgcaa tgattgaagg agaaattgag tctttacatt cagagaattc aggaaaatca     1440

ggccaagagc attggtttac tgaattacca cctgtgttaa catttgaatt gtcaagattt     1500

gaatttaatc aggcattggg aagaccagaa aaaattcaca acaaattaga atttccccaa     1560

gttttatatt tggacagata catgcacaga aacagagaaa taacaagaat taagagggaa     1620

gagatcaaga gactgaaaga ttacctcacg gtattacaac aaaggctaga aagatattta     1680

agctatggtt ccggtcccaa acgattcccc ttggtagatg ttcttcagta tgcattggaa     1740

tttgcctcaa gtaaacctgt ttgcacttct cctgttgacg atattgacgc tagttcccca     1800

cctagtggtt ccataccatc acagacatta ccaagcacaa cagaacaaca gggagcccta     1860

tcttcagaac tgccaagcac atcaccttca tcagttgctg ccatttcatc gagatcagta     1920

atacacaaac catttactca gtcccggata cctccagatt tgcccatgca tccggcacca     1980

aggcacataa cggaggaaga actttctgtg ctggaaagtt gtttacatcg ctggaggaca     2040

gaaatagaaa atgacaccag agatttgcag gaaagcatat ccagaatcca tcgaacaatt     2100

gaattaatgt actctgacaa atctatgata caagttcctt atcgattaca tgccgtttta     2160

gttcacgaag gccaagctaa tgctgggcac tactgggcat atatttttga tcatcgtgaa     2220

agcagatgga tgaagtacaa tgatattgct gtgacaaaat catcatggga agagctagtg     2280

agggactctt ttggtggtta tagaaatgcc agtgcatact gtttaatgta cataaatgat     2340

aaggcacagt tcctaataca agaggagttt aataaagaaa ctgggcagcc ccttgttggt     2400

atagaaacat taccaccgga tttgagagat tttgttgagg aagacaacca acgatttgaa     2460

aaagaactag aagaatggga tgcacaactt gcccagaaag ctttgcagga aaagctttta     2520

gcgtctcaga aattgagaga gtcagagact tctgtgacaa cagcacaagc agcaggagac     2580

ccagaatatc tagagcagcc atcaagaagt gatttctcaa agcacttgaa agaagaaact     2640

attcaaataa ttaccaaggc atcacatgag catgaagata aaagtcctga aacagttttg     2700

cagtcggcaa ttaagttgga atatgcaagg ttggttaagt tggcccaaga agacacccca     2760

ccagaaaccg attatcgttt acatcatgta gtggtctact ttatccagaa ccaggcacca     2820

aagaaaatta ttgagaaaac attactagaa caatttggag atagaaattt gagttttgat     2880

gaaaggtgtc acaacataat gaaagttgct caagccaaac tggaaatgat aaaacctgaa     2940

gaagtaaact tggaggaata tgaggagtgg catcaggatt ataggaaatt cagggaaaca     3000

actatgtatc tcataattgg gctagaaaat tttcaaagag aaagttatat agattccttg     3060

ctgttcctca tctgtgctta tcagaataac aaagaactct tgtctaaagg cttatacaga     3120

ggacatgatg aagaattgat atcacattat agaagagaat gtttgctaaa attaaatgag     3180

caagccgcag aactcttcga atctggagag gatcgagaag taaacaatgg tttgattatc     3240

atgaatgagt ttattgtccc atttttgcca ttattactgg tggatgaaat ggaagaaaag     3300

gatatactag ctgtagaaga tatgagaaat cgatggtgtt cctaccttgg tcaagaaatg     3360

gaaccacacc tccaagaaaa gctgacagat tttttgccaa aactgcttga ttgttctatg     3420

gagattaaaa gtttccatga gccaccgaag ttaccttcat attccacgca tgaactctgt     3480

gagcgatttg cccgaatcat gttgtccctc agtcgaactc ctgctgatgg aagataaact     3540

gcacactttc cctgaacaca ctgtataaac tctttttagt tcttaaccct tgccttcctg     3600

tcacagggtt tgcttgttgc tgctatagtt tttaactttt ttttatttta ataactgcaa     3660

aagacaaaat gactatacag actttagtca gactgcagac aataaagctg aaaatcgcat     3720

ggcgctcaga cattttaacc ggaactgatg tataatcaca aatctaattg attttattat     3780

ggcaaaacta tgcttttgcc accttcctgt tgcagtatta ctttgctttt atcttttctt     3840

tctcaacagc tttccattca gtctggatcc ttccatgact acagccattt aagtgttcag     3900

cactgtgtac gatacataat atttggtagc ttgtaaatga aataaagaat aaagttttat     3960

ttatggctac cta                                                        3973


<210> 576
<211> 5216
<212> DNA
<213> Homo sapiens

<400> 576
aagcagcccg cggaccggca gcaaaggaac gtgcgaacgc gtgacgccgc ccgactggct       60

cgcgctctcc cgtgccccgg cgtcctccgc ccgctcatgg cccgggccgc cgcggacgag      120

cggcgctgag gcgggccgcg tggagacgtg aggcggccgc cgtggccctc acagtcggcg      180

tttcgccgcc tgcccgcggt gcccgcgcac gccggccgcc atcgccttcg cgcctggctg      240

gcgggggcgc tgtcctccca ggccgtccgc gccgctccct ggagctcggc ggagcgcggc      300

agccagggcc ggcggaggcg cgaggagccg ggcgccaccg ccgccgccgc cgccgccgcc      360

gcgggggcca tgaccgtgga gcagaacgtg ctgcagcaga gcgcggcgca gaagcaccag      420

cagacgtttt tgaatcaact gagagaaatt acggggatta atgacaccca gatactacag      480

caagccttga aggatagtaa tggaaacttg gaattagcag tggctttcct tactgcgaag      540

aatgctaaga cccctcagca ggaggagaca acttactacc aaacagcact tcctggcaat      600

gatagataca tcagtgtggg aagccaagca gatacaaatg tgattgatct cactggagat      660

gataaagatg atcttcagag agcaattgcc ttgagtttgg ccgaatcaaa cagggcattc      720

agggagactg gaataactga tgaggaacaa gccattagca gagttcttga agccagcata      780

gcagagaata aagcatgttt gaagaggaca cctacagaag tttggaggga ttctcgaaac      840

ccttatgata gaaaaagaca ggacaaagct cccgttgggc taaagaatgt tggcaatact      900

tgttggttta gtgctgttat tcagtcatta tttaatcttt tggaatttag aagattagtt      960

ctgaattaca agcctccatc aaatgctcaa gatttacccc gaaaccaaaa ggaacatcgg     1020

aatttgcctt ttatgcgtga gctgaggtat ctatttgcac ttcttgttgg taccaaaagg     1080

aagtatgttg atccatcaag agcagttgaa attcttaagg atgctttcaa atcaaatgac     1140

tcacagcagc aagatgtgag tgagtttaca cacaaattat tagattggtt agaagatgcc     1200

ttccaaatga aagctgaaga ggagacggat gaagagaagc caaagaaccc catggtagag     1260

ttgttctatg gcagattcct ggctgtggga gtacttgaag gtaaaaaatt tgaaaacact     1320

gaaatgtttg gtcagtaccc acttcaggtc aatgggttca aagatctgca tgagtgccta     1380

gaagctgcaa tgattgaagg agaaattgag tctttacatt cagagaattc aggaaaatca     1440

ggccaagagc attggtttac tgaattacca cctgtgttaa catttgaatt gtcaagattt     1500

gaatttaatc aggcattggg aagaccagaa aaaattcaca acaaattaga atttccccaa     1560

gttttatatt tggacagata catgcacaga aacagagaaa taacaagaat taagagggaa     1620

gagatcaaga gactgaaaga ttacctcacg gtattacaac aaaggctaga aagatattta     1680

agctatggtt ccggtcccaa acgattcccc ttggtagatg ttcttcagta tgcattggaa     1740

tttgcctcaa gtaaacctgt ttgcacttct cctgttgacg atattgacgc tagttcccca     1800

cctagtggtt ccataccatc acagacatta ccaagcacaa cagaacaaca gggagcccta     1860

tcttcagaac tgccaagcac atcaccttca tcagttgctg ccatttcatc gagatcagta     1920

atacacaaac catttactca gtcccggata cctccagatt tgcccatgca tccggcacca     1980

aggcacataa cggaggaaga actttctgtg ctggaaagtt gtttacatcg ctggaggaca     2040

gaaatagaaa atgacaccag agatttgcag gaaagcatat ccagaatcca tcgaacaatt     2100

gaattaatgt actctgacaa atctatgata caagttcctt atcgattaca tgccgtttta     2160

gttcacgaag gccaagctaa tgctgggcac tactgggcat atatttttga tcatcgtgaa     2220

agcagatgga tgaagtacaa tgatattgct gtgacaaaat catcatggga agagctagtg     2280

agggactctt ttggtggtta tagaaatgcc agtgcatact gtttaatgta cataaatgat     2340

aaggcacagt tcctaataca agaggagttt aataaagaaa ctgggcagcc ccttgttggt     2400

atagaaacat taccaccgga tttgagagat tttgttgagg aagacaacca acgatttgaa     2460

aaagaactag aagaatggga tgcacaactt gcccagaaag ctttgcagga aaagctttta     2520

gcgtctcaga aattgagaga gtcagagact tctgtgacaa cagcacaagc agcaggagac     2580

ccagaatatc tagagcagcc atcaagaagt gatttctcaa agcacttgaa agaagaaact     2640

attcaaataa ttaccaaggc atcacatgag catgaagata aaagtcctga aacagttttg     2700

cagtcgatca tgatgacacc gaacatgcaa ggtattatca tggcgatagg taaatccagg     2760

agtgtatatg acaggtgtgg ccctgaagca gggttcttta aggcaattaa gttggaatat     2820

gcaaggttgg ttaagttggc ccaagaagac accccaccag aaaccgatta tcgtttacat     2880

catgtagtgg tctactttat ccagaaccag gcaccaaaga aaattattga gaaaacatta     2940

ctagaacaat ttggagatag aaatttgagt tttgatgaaa ggtgtcacaa cataatgaaa     3000

gttgctcaag ccaaactgga aatgataaaa cctgaagaag taaacttgga ggaatatgag     3060

gagtggcatc aggattatag gaaattcagg gaaacaacta tgtatctcat aattgggcta     3120

gaaaattttc aaagagaaag ttatatagat tccttgctgt tcctcatctg tgcttatcag     3180

aataacaaag aactcttgtc taaaggctta tacagaggac atgatgaaga attgatatca     3240

cattatagaa gagaatgttt gctaaaatta aatgagcaag ccgcagaact cttcgaatct     3300

ggagaggatc gagaagtaaa caatggtttg attatcatga atgagtttat tgtcccattt     3360

ttgccattat tactggtgga tgaaatggaa gaaaaggata tactagctgt agaagatatg     3420

agaaatcgat ggtgttccta ccttggtcaa gaaatggaac cacacctcca agaaaagctg     3480

acagattttt tgccaaaact gcttgattgt tctatggaga ttaaaagttt ccatgagcca     3540

ccgaagttac cttcatattc cacgcatgaa ctctgtgagc gatttgcccg aatcatgttg     3600

tccctcagtc gaactcctgc tgatggaaga taaactgcac actttccctg aacacactgt     3660

ataaactctt tttagttctt aacccttgcc ttcctgtcac agggtttgct tgttgctgct     3720

atagttttta actttttttt attttaataa ctgcaaaaga caaaatgact atacagactt     3780

tagtcagact gcagacaata aagctgaaaa tcgcatggcg ctcagacatt ttaaccggaa     3840

ctgatgtata atcacaaatc taattgattt tattatggca aaactatgct tttgccacct     3900

tcctgttgca gtattacttt gcttttatct tttctttctc aacagctttc cattcagtct     3960

ggatccttcc atgactacag ccatttaagt gttcagcact gtgtacgata cataatattt     4020

ggtagcttgt aaatgaaata aagaataaag ttttatttat ggctacctat gtgtttgtaa     4080

gcaggtatat tgtatattag tgtattagta atactagata aatgaatttt gtctggggat     4140

taagattgga tagttaatag attaatacaa tcttttaatt ctgctctaat gctagcaaat     4200

tggaaaatgt ttaagtcttt gacacttaaa tttatctata tttttaacaa agttcttgaa     4260

cttagtatgg caccggaacc tgttttgaat tcagtcaggt ttttactcaa gtaagtggtt     4320

gatttttttt aagtcaaact acactgaaac ttttatcctt ttcttagatt aatcttactt     4380

tttaaatgta tttacaatat acagcaaggt gattatttca agagaatccc aaagtacttg     4440

aataagggct attgtaaaat ttaaaagaaa tatttatata tacacatata tacacataca     4500

cacatgtata tatatattct tcataatgga ggacaatgtt ttgcaatata taaatcattc     4560

tatttttgta aattgtatat cactttaatt gaaaatgttc tctactaatt aatactgtga     4620

aacaaaattg atgttgttta actagaagtt atgagtatct taactgcctt tattcctttt     4680

caaaaaggaa aaagctgtag aacattttgt agatgaaact actgtttaag attaatgaat     4740

taatattgtg aatgaaaatc aaaatccata ctttaaaggt aatcatgtta ctaacaacct     4800

atttttgaat tcataaaaat ttctttataa atgatgtttt gtgaacatag taaaatagac     4860

cattatacta tgtgtatgtt tgatacagcg tcgccaaaac tagtgttctt tattagtgcc     4920

tctcacaaaa gatcctggat ggaggagtaa gatgaaatat tatgctatta tatgatgctg     4980

tttgtaaagg tattaatgta ctagtaaggt gttaatgaca aggaattagt actattcctg     5040

ttgtaaagtt agattttgca tattgtatct atcaaaatat gtttgggttt agattttaag     5100

ttgtctactg agcagatttc tgcattggtt ttccagtcct gttaaaagtt tagaaacttc     5160

atatgtgtca tcacagcttt tgtaaagaaa gtatccttaa tattttatga cattct         5216


<210> 577
<211> 6354
<212> DNA
<213> Homo sapiens

<400> 577
aggcgggtct gaggtttggt gactgcgggg caggccgggg gcagctgtct gtctggctct       60

ttttgacagc ccccagtgcg aaaggctgcc agcatgtcat cagtgagccc catccagatc      120

cccagtcgcc tcccgctgct gctcacccac gagggcgtcc tgctgcccgg ctccaccatg      180

cgcaccagcg tggactcggc ccgcaacctg cagctggtgc ggagccgcct tctgaagggc      240

acgtcgctgc aaagcaccat cctgggcgtc atccccaaca cgcctgaccc cgccagcgac      300

gcgcaggacc tgccgccgct gcacaggatt ggcacagctg cactggccgt tcaggttgtg      360

ggcagtaact ggcccaagcc ccactacact ctgttgatta caggcctatg ccgtttccag      420

attgtacagg tcttaaaaga gaagccatat cccattgctg aagtggagca gttggaccga      480

cttgaggagt ttcccaacac ctgtaaaatg agggaggagc taggagaact atcagagcag      540

ttttacaaat atgcagtaca attggttgaa atgttggata tgtctgtccc tgcagttgct      600

aaattgagac gtcttttaga tagtcttcca agggaagctt taccagacat cttgacatca      660

attatccgaa caagcaacaa agagaaactc cagattttag atgctgtgag cctagaggag      720

cggttcaaga tgactatacc actgcttgtc agacaaattg aaggcctgaa attgcttcaa      780

aaaaccagaa aacccaagca agatgatgat aagagggtta tagcaatacg ccctattagg      840

agaattacac atatctcagg tactttagaa gatgaagatg aagatgaaga taatgatgac      900

attgtcatgc tagagaaaaa aatacgaaca tctagtatgc cagagcaggc ccataaagtc      960

tgtgtcaaag agataaagag actcaaaaaa atgcctcagt caatgccaga atatgctctg     1020

actagaaatt atttggaact tatggtagaa cttccttgga acaaaagtac aactgaccgc     1080

ctggacatta gggcagcccg gattcttctg gataatgacc attacgccat ggaaaaattg     1140

aagaaaagag tactggaata cttggctgtc agacagctca aaaataacct gaagggccca     1200

atcctatgct ttgttggccc tcctggagtt ggtaaaacaa gtgtgggaag atcagtggcc     1260

aagactctag gtcgagagtt ccacaggatt gcacttggag gagtatgtga tcagtctgac     1320

attcgaggac acaggcgcac ctatgttggc agcatgcctg gtcgcatcat caacggcttg     1380

aagactgtgg gagtgaacaa cccagtgttc ctattagatg aggttgacaa actgggaaaa     1440

agtctacagg gtgatccagc agcagctctg cttgaggtgt tggatcctga acaaaaccat     1500

aacttcacag atcattatct aaatgtggcc tttgaccttt ctcaagttct ttttatagct     1560

actgccaaca ccactgctac cattccagct gccttgttgg acagaatgga gatcattcag     1620

gttccaggtt atacacagga ggagaagata gagattgccc ataggcactt gatccccaag     1680

cagctggaac aacatgggct gactccacag cagattcaga taccccaggt caccactctt     1740

gacatcatca ccaggtatac cagagaggca ggggttcgtt ctctggatag aaaacttggg     1800

gccatttgcc gagctgtggc cgtgaaggtg gcagaaggac agcataagga agccaagttg     1860

gaccgttctg atgtgactga gagagaaggt tgcagagaac acatcttaga agatgaaaaa     1920

cctgaatcta tcagtgacac tactgacttg gctctaccac ctgaaatgcc gattttgatt     1980

gatttccatg ctctgaaaga catccttggg cccccgatgt atgaaatgga ggtatctcag     2040

cgtttgagtc agccaggagt agcaataggt ttggcttgga ctcccttagg tggagaaatc     2100

atgttcgtgg aggcgagtcg aatggatggc gagggccagt taactctgac cggccagctc     2160

ggggacgtga tgaaggagtc cgcccacctc gctatcagct ggctccgcag caacgcaaag     2220

aagtaccagc tgaccaatgc ttttggaagt tttgatcttc ttgacaacac agacatccat     2280

ctgcacttcc cagctggagc tgtcacaaaa gatggaccat ctgctggagt taccatagta     2340

acctgtctcg cctcactttt tagtgggcgg ctggtacgtt cagatgtagc catgactgga     2400

gaaattacac tgagaggtct tgttcttcca gtgggtggaa ttaaagacaa agtgctggcg     2460

gcacacagag cgggactgaa gcaagtcatt attcctcgga gaaatgaaaa agaccttgag     2520

ggaatcccag gcaacgtacg acaggattta agttttgtca cagcaagctg cctggatgag     2580

gttcttaatg cagcttttga tggtggcttt actgtcaaga ccagacctgg tctgttaaat     2640

agcaaactgt aggtccaaat ctcaattttt tagaatttta agttatgaag tgctcaaagg     2700

tactgacaca gttgatttta ttcacaccat taggggtatg caagatgtcc ctgttttata     2760

aacataatca caacagtaat aaacctcaag tagtggctag tgtttagtat agaaatataa     2820

gatgttgatt tagtaaactg ataaaaatcg aattcttgtc tttttagtgg gatccttact     2880

gtccctggaa agatatagca tagtggttct cagcacagtc tccagaacag aagcatctgt     2940

agtacctggt aacttgttag aaatgtacat tctcaggctc cacagcaggc cgcctgaatc     3000

aaatcctggg aggtggggac agaaatctgt gttttaagaa gccttccagg taattctgct     3060

gcacactcaa gttcaggaac caccggtata gaccattacc ttagtggatt tacctgtaga     3120

gtttattgga tcctgaaacc aatcaattac ttagaactag gcaaagatga aagtatagcc     3180

aactattctt ggctatatat atatattcaa gtgggccggg cgtgatggct cacacctgta     3240

attccagcac tttgggaggt cgaggtaggc agatcaccga gcccaagagt tcaagacaat     3300

cctggccaac ggcgaaactc tgtctctaca aaaaatatac aggcgtgtta gcatgtgcct     3360

gtaatcccag cttcttggga agctgaggca caagaattgc ctgaacccag gaggtggagg     3420

ttgcagtgag ctgggatcgc gccattgcac tccagcctgg ctgacagagc gagactgtct     3480

ctaaaaaaaa aagactcaag tggaccctac aatgaagcct acacatccca atagaagccc     3540

cttcttatgc tgagggaagc agccctcaga acatgatagc ttgtatccag cagagtggca     3600

cgtgctggca cacctcacag aagcaccctg gccctggatg cctgcaacct cagaagagtg     3660

cagctcccag agggaggcag ccatccatct gggatggtcc taagcatgga atcctaactc     3720

ctgattccgt ctcctatttc ttgcttggct acgccagttc ccaaatctgg tagatgtcca     3780

tgcccatgtg ctcctgctgg gactcaattc aggctatgta tgactatgaa gtcaggctca     3840

tctgcttact ggctgtgtga actttttgta tcttggtttt cttcatccat gaaatccaag     3900

taatactacc taattgttac tgtggagatt aagttcaaat gcaatgtata gtaatattaa     3960

gcaatttcta gttattattc tagccagtaa tggacttcag aatcttttat tacacaatat     4020

aagaatatgt atgtaaagac attttggaat ttcctggatg agaaggaagt ctgggctggg     4080

catggtggct cacgcctgta accctagcac tttaggaaat cgaggcgagt ggatcactta     4140

agctcaggag ttcaaggcca gcctgggcaa catggcaaaa ccccatttct acaaaaaata     4200

caaaaattag ctgggcatgg tggcacccgc ctgtagtcca gctacttgag gctgagatgg     4260

gaggatgagg gaggtcgggg ctgcagtgag ccaagatcac gccactgcac tccagcaccc     4320

tgggcgacag agtgagaccc tgtctcaaaa aaaaaaaaaa aaaaaaagat tgggccaaaa     4380

tactgtgata aaatagcagg cctgctgata aaagtttatc tgaatgcatt gagaggaaaa     4440

gtccagacct aggactagtt atggcagttg gagagaaaga acatcgggat gtttgaaaat     4500

atgccattga ctatcttaac tactgtaatt ttatcatttc caacgtcatc taactgggga     4560

ctagaacaaa ctgtgaattc actttcagca accagagggc gctaatccac acccacatcg     4620

ctctgccctg ttccacccag caggggcaac aaggatataa cttggggttc tcggtattct     4680

tcctttagtc ctgacacagg cagccttgca ctttgtagca gcaggagggc acttgcttta     4740

agcatatctt tcgaaaggca tccattgaga gaataatgca ttctcccctt gctgtgtatg     4800

acatggaaca gtatgaccat tgcactagct ttgtttttgg tttgttttgt ttttttttta     4860

attccagggg tgggaggttg gttggttgaa gtctaagctc ttcctttttc acctgggttt     4920

tttttttttg gggggggtgg ggggttaggg gtggggcggg tggggaagag ccaaaatttt     4980

aaccattttt aagcatataa tttgggggta tcagttactg gatctaagca tgtccactct     5040

acacgctttt tttttttttt tttttttttt tttttgagat ggagtcttgc tctgttaccc     5100

aggctgcact gcagtggcat gatctcggct cactgcaacc tctgcctccc cagttcaagc     5160

aattctcatg cctcagcctc ccaagtagct gggaccacag gtgtgtgcca ccacgcccag     5220

ctaatttttg tattttttag tagagacagg gtttcaccat gttggccagg ctggtctcaa     5280

actcccaacc tcaaatgatc cggccacctt ggcctcccaa aatgctggca ttacaggcgt     5340

gagccaccac acccggctta catgcatttt ttatcaccac aaactgaaac tctgtaccca     5400

ctgaaaaaga gctccaaatt ccaccctcac cccagaccct ggtaaccact atttcacttt     5460

ctttctgaat ttcccttcat atgagtggga tcaaacaaga gttgtccttt tgtgtttagc     5520

attcttactt agcaagccat caactgctcg aacagtcact ggggcaacta cttttcgccc     5580

agtgtcctcc agaaaagaaa gatctggagg gtcaggccac tctttttctt caaaataatg     5640

gggtgcagaa gggtagggat gaacctcttc ctcctttgcc actttagctt tagctcaaag     5700

gaactccaac tttttattat ttgcaacagt tagctttctt tgtttcacat ctctgccttg     5760

cagaaccatg acctatcaag gtgttttgtc aaacaaaaac taatactttc cctgggaaaa     5820

agccatgtgg tagcaagtac cagaaatttt tatggccaaa taatacacca ctatatccat     5880

agaccgcatt tggtttatcc actcatctgc tgattgtttc cccctcttgg gtattatgag     5940

taatgctatg aacatgggtg tacacatctc tcttgaagtc ccttcttagg tcctttaggg     6000

atacatatcc aggagcagaa ctactagatc acatatgcta aggtctgaat gtccccccac     6060

caaattcgta tgttgaagca accaccaacg tgataggtga ggctttagga ggtgattatg     6120

tcatgagagc tccatcctca ttaatggatt tagtgccttt ataaaggggc tcaagggaac     6180

caattacctc ctttttgccc ttcgattccc ttccaccata tgaggacaca gcaacaggcc     6240

ccgtcctaga agctgagact gggccctcaa tagatgatac cagtctgcca gcacgctgat     6300

cgtgggcttc tcagtcttca caactatgag aaataaattc gtacttttaa atta           6354


<210> 578
<211> 1286
<212> DNA
<213> Homo sapiens

<400> 578
caccaccgcc cctgccgcca tcgccacctc cgccgctgcc gccttggggc cctcctcctt       60

caccgccccc ttcaccacct ctacacgttc taggccttct gtcctggaga agaagctata      120

gtcgttctcc cttgtgggcc cggggcgcag ccatggcgga cggcggcggc ggcgggggaa      180

ctggcgcggt gggcggcggc ggaactagcc aggcctctgc cggggcagcg actggcgcta      240

ctggggccag cgggggcggt ggccccatca acccggcctc gctgcctccc ggcgacccgc      300

agctcatcgc tctcatcgtg gagcagctca agagccgggg cctttttgac agcttccgcc      360

gggactgcct ggccgacgtg gacaccaagc cagcttacca aaacctgagg cagaaagtgg      420

ataattttgt gtcaacacat ctggacaagc aggaatggaa tcctacgatg aacaaaaacc      480

agttgcgaaa tggtctgagg cagagtgtgg ttcaaatacg ccagacacct tttgaaagct      540

aatttttggt gaagaaatgg attcggttac ataagagtgc aacttcagac tgaagatagg      600

ccaaggtcgt cactgatctc aagatttcaa ccttgaccat gggcagtgac cagattgaaa      660

ggggagcaag ttcggcagtg ggagagttga ccgtgtcacc ccctgcattg tgctgccatt      720

tggccagcct gtccaagggc atgacaccaa gtagacacta cagagagaga aacactacag      780

caacccaggg ttgtcctgaa acagactttt atacttgaac atggagactg cacatggact      840

ttagggtttg tgctgtggga taaacggaag ctacagtgag aacatagcca gtcccaaaga      900

caatttcaaa gaaaaatgac agtaaagatt agctgggagt agtctttgac agtgcttatt      960

tgatactgtc tctcagagtt tgcaaaccag attgtacaag tcattagcgt cagatagctt     1020

taaagttgtg accttcttgt acatgaatct tctagccagt ttcctttcct ttgtaacgaa     1080

acatgaaatc ctagaatgta tgagaagttc agacattagg cataaggaaa ctcgtttgca     1140

ggctctctgt ccagggctgc ttcctgtcct ggaggggcca gtgagtctta ggtatgttta     1200

ttttattctc acatttgtgt ttttttagaa aagtgaatgg tcaataaatg gcttatcttt     1260

cataataaaa ttatttgata ctttta                                          1286


<210> 579
<211> 1785
<212> DNA
<213> Homo sapiens

<400> 579
cgagccggca aaggcttggg tgtgagacag cagcggtggc agacaccgca gaagcaaaga       60

gcagtgaggc tcctgcattc gggtggagca ccatggacga agctggcagc tctgcgagcg      120

gcgggggctt ccgcccgggc gtggacagcc tggacgaacc gcccaacagc cgcatcttcc      180

ttgtgatcag caagtacaca cctgagtcgg tgctgaggga gcgcttctcg ccttttggcg      240

acatccagga catctgggtg gtgcgggaca agcacaccaa ggagtccaag ggcattgctt      300

tcgtcaagtt cgcccgcagc tcacaggcct gcagggccat ggaggagatg catggccagt      360

gcctcggccc caacgacacc aagcccatca aggttttcat tgctcagtcc cgatcatctg      420

gaagtcaccg agatgttgaa gatgaagaac ttacaagaat ctttgttatg ataccaaagt      480

cctacacaga agaagatctg cgggaaaaat ttaaggtgta tggagatatc gagtattgca      540

gcattattaa gaataaagtg actggagaaa gtaaaggttt gggctacgta cgatacttaa      600

aaccatcaca agctgcccaa gcaatagaaa actgtgatcg aagttttaga gcaatcttgg      660

ctgaacctaa aaataaagca tctgaatcct ctgaacaaga ttattatagt aatatgaggc      720

aagaagcttt gggacatgaa cctagagtaa atatgtttcc atttgaacaa caatctgaat      780

tttcaagttt tgacaagaat gatagccgag gccaggaagc aatctccaaa cgcttgtcag      840

ttgtatcaag agttcctttc actgaagaac agcttttcag catttttgat atagtaccag      900

gattggaata ttgtgaagtt caacgagatc cttattcaaa ttatggtcat ggagtggttc      960

agtattttaa tgtagcatca gctatttatg caaaatacaa attacatgga tttcagtacc     1020

ctcctgggaa ccgaataggt gtttccttca ttgatgatgg aagtaatgca acagatctcc     1080

ttagaaaaat ggcaacacag atggtagctg cacagcttgc atcaatggtg tggaataacc     1140

caagtcagca acaatttatg caatttggag gaagctctgg atcacagttg cctcaaatcc     1200

agacagatgt tgtacttcca tcatgcaaaa aaaaagctcc tgctgaaact cctgtgaaag     1260

aaagactttt tattgtgttt aatcctcatc ctttaccttt agacgtatta gaagatatat     1320

tctgtcgttt tggtaacctg atcgaagttt accttgtgtc aggaaaaaat gtggggtatg     1380

ccaagtatgc cgatagaata agtgctaatg atgccattgc cactctacat ggaaagattc     1440

tgaatggggt gagacttaaa gttatgctgg cagattcgcc aagagaagaa tctaacaaac     1500

ggcaaagaac ttactgattc ttgagaacaa agactaaata atgacataat cctcagctga     1560

ctgactgaaa atgtgactgg acgcattccc tgtggacagt tgacagcttt ttttttttcc     1620

atatacctga tagtctgtgt acagcattgt tttgtctggg aagcagggat tgctgacatg     1680

tatttttgaa tccatacatt aatgctaaaa cgaatatagt agttgttcct tagagcaata     1740

tgttgttacg tgtagcagaa ataaagtttt ctttgcttaa ctaaa                     1785


<210> 580
<211> 2903
<212> DNA
<213> Homo sapiens

<400> 580
ggcggcggag ccgactcgtc gcggccgagg cgcgcgcggt ccgtgccggc gtcagtctgg       60

gattggccgg cccgcgactt cctccgcccc ctgccaatcg ccggggacga cttccgtggg      120

tttttccggc tcccccgcgt cgctaaggag cgacgggctg tcggccagac cccgagttct      180

cggtgcgctc agcggccgcc gacgctagga ggccgcgctc cgcccccgct accatgaggc      240

cccggaaagc cttcctgctc ctgctgctct tggggctggt gcagctgctg gccgtggcgg      300

gtgccgaggg cccggacgag gattcttcta acagagaaaa tgccattgag gatgaagagg      360

aggaggagga ggaagatgat gatgaggaag aagacgactt ggaagttaag gaagaaaatg      420

gagtcttggt cctaaatgat gcaaactttg ataattttgt ggctgacaaa gacacagtgc      480

tgctggagtt ttatgctcca tggtgtggac attgcaagca gtttgctccg gaatatgaaa      540

aaattgccaa catattaaag gataaagatc ctcccattcc tgttgccaag atcgatgcaa      600

cctcagcgtc tgtgctggcc agcaggtttg atgtgagtgg ctaccccacc atcaagatcc      660

ttaagaaggg gcaggctgta gactacgagg gctccagaac ccaggaagaa attgttgcca      720

aggtcagaga agtctcccag cccgactgga cgcctccacc agaagtcacg cttgtgttga      780

ccaaagagaa ctttgatgaa gttgtgaatg atgcagatat cattctggtg gagttttatg      840

ccccatggtg tggacactgc aagaaacttg cccccgagta tgagaaggcc gccaaggagc      900

tcagcaagcg ttctcctcca attcccctgg caaaggtcga cgccaccgca gaaacagacc      960

tggccaagag gtttgatgtc tctggctatc ccaccctgaa aattttccgc aaaggaaggc     1020

cttatgacta caacggccca cgagaaaaat atggaatcgt tgattacatg atcgagcagt     1080

ccgggcctcc ctccaaggag attctgaccc tgaagcaggt ccaggagttc ctgaaggatg     1140

gagacgatgt catcatcatc ggggtcttta agggggagag tgacccagcc taccagcaat     1200

accaggatgc cgctaacaac ctgagagaag attacaaatt tcaccacact ttcagcacag     1260

aaatagcaaa gttcttgaaa gtctcccagg ggcagttggt tgtaatgcag cctgagaaat     1320

tccagtccaa gtatgagccc cggagccaca tgatggacgt ccagggctcc acccaggact     1380

cggccatcaa ggacttcgtg ctgaagtacg ccctgcccct ggttggccac cgcaaggtgt     1440

caaacgatgc taagcgctac accaggcgcc ccctggtggt cgtctactac agtgtggact     1500

tcagctttga ttacagagct gcaactcagt tttggcggag caaagtccta gaggtggcca     1560

aggacttccc tgagtacacc tttgccattg cggacgaaga ggactatgct ggggaggtga     1620

aggacctggg gctcagcgag agtggggagg atgtcaatgc cgccatcctg gacgagagtg     1680

ggaagaagtt cgccatggag ccagaggagt ttgactctga caccctccgc gagtttgtca     1740

ctgctttcaa aaaaggaaaa ctgaagccag tcatcaaatc ccagccagtg cccaagaaca     1800

acaagggacc cgtcaaggtc gtggtgggaa agacctttga ctccattgtg atggacccca     1860

agaaggacgt cctcatcgag ttctacgcgc catggtgcgg gcactgcaag cagctagagc     1920

ccgtgtacaa cagcctggcc aagaagtaca agggccaaaa gggcctggtc atcgccaaga     1980

tggacgccac tgccaacgac gtccccagcg accgctataa ggtggagggc ttccccacca     2040

tctacttcgc ccccagtggg gacaaaaaga acccagttaa atttgagggt ggagacagag     2100

atctggagca tttgagcaag tttatagaag aacatgccac aaaactgagc aggaccaagg     2160

aagagctttg aaggcctgag gtctgcggaa ggtgggagga ggcagacgcc ctgcgtggcc     2220

catggtcggg gcgtccacgc cgaggccggc aacaaacgac agtatctcgg attccttttt     2280

tttttttttt aattttttat actttggtgt ttcacttcat gctctgaata ctgaataacc     2340

atgaatgact gaatagttta gtccagattt ttacagagga tacatctatt tttatcatta     2400

tttggggttt gaaaaatttt tttttacacc ttctaatttc tttatttctc aaagcagata     2460

attcttctgt gtgaaaatgt tttctttttt taatttaagg tttaaaattc cttttccaaa     2520

tcatgttgat tttgctcttt gctttttcgt tgtctgagaa attgttggcg tagatttggc     2580

ttctggtatg tgtttctgat tgcttcctgt tgagcacaaa gtgagagctg ccactgagca     2640

gccctgccag gggtgctgtt tcaggctggg catcgccagg cggcctccct gcaaaccaag     2700

ggctgggggc aaaggggcat gatccagggt cccccagggt gggctcagct ccagggagag     2760

gccacccacg tggcagcccc acctcttgag agcccccagt gccggagcag aaaggaccct     2820

ggacccagag gcagatactg cggggtggta gaaaaggtag agtaggctgt ggcaatggaa     2880

taaaacacga ttaaaaacgt taa                                             2903


<210> 581
<211> 1769
<212> DNA
<213> Homo sapiens

<400> 581
caagagcctc ctgatctagc agccaagact ccccctgacc tttggccatg taccccaacc       60

ctctcatcta ctgcacctgc tgggacccct ggaacttggg accacggaag ctaatcaaga      120

cccctcaact accacgcaag aactccacag ggagttccaa gctaactcct cttgtaccag      180

ctccaaaaaa tcacaattac ctccaaccaa caaaacctgt tgtttcccca aaaatgaaaa      240

tccattcagc aaggcaagaa gagactaata aatcatttta tgaagtgatc aacgtgtcac      300

ctggctatca acttgttcgg aatcgggaac agatttctgt caccttaggg gatgagatgt      360

ttgataggaa aaagcggtgg gaatcggaga tcccggacaa aggcagattt tccaggacca      420

acatcatttc tgacctagaa gagcaaatct cagagctgac agcaataatt gaacaaatga      480

acagagacca ccagtctgcc cagaaattgc tctccagtga aatggatctc cgctgtgctg      540

agatgaaaca gaactttgaa aacaagaaca gggagctcaa agaggcccat gaagcagaac      600

tcagtgagtt ggagaacaac tacaaagcag ccttgaaggc agagaagttg gctgcccaag      660

agaagctaga ggagatggga aaagaataca agtatttgaa gaatatgttt cgtacgtatc      720

aggacagtat ttatgatgaa atggaagaga agtggtcaaa acagaaggcg aaatggaaga      780

aggatgagaa gttcgagcga gaaaatatcc tgctacagca aaaaaaaaag atgaccaaaa      840

aattcgaaat ggagtcagga gaagaagata agaaaataaa tgaatcctgc agtgctgtct      900

ttgagaactt cattcaagag aaggaggagc tcttgaaaca acatcaaagt gacaccttgc      960

aattagaaga gctgagaaaa accaaagagg tgccctggag aagagaccaa ataaatagac     1020

attggcatga tgtcctgcaa cagcttcttc ttatgcaggt catgcaggaa gaattgcatg     1080

cacaagccct tatcctagag tcactgaaca caaacctcta ctatacccag ttggaactcc     1140

agaaagagaa agctatagtg ggaaatctgg agaaaatgct tcaaaccaag tttgctgaaa     1200

ctgaagaaaa gtataagcac accatacaga tcctgacgga agagaacatt catctgaagc     1260

aaaagataat ttctaagaat gaagaaattt gtgaaggatg ttctgggaga ttggcctcta     1320

ttactgtttc taaggatgat tctgacactg tgcaagatgg tagcaagaaa ggacaagaat     1380

cataaacaaa aagttgctct gcattgttga agatggttgg cacaccattt ctgtaggccc     1440

aggaaactcc tgggagggtt ttcttgagaa aatgcatata atgagtttag ttcttgggtt     1500

gctctgactc tctgaatgtc tgaaaatgtt tgaattcgca tctgaatttc acagcttatc     1560

acggactctt cactgaaaaa tgatgctctc catactggga gctgagcttt ctctgagttt     1620

tgtactattt ttcttctacc ttgacgtatt tcgttagaaa gaaactgatt tgaaggcctt     1680

cttcatattg aacttttact atatttggga ggtgtacctt tgtcccctgg ggcatttagg     1740

tagcaaaaaa agatgatgtg ttgatttta                                       1769


<210> 582
<211> 2104
<212> DNA
<213> Homo sapiens

<400> 582
agcgggccgt cggttgggcg cagacaggcc gcagaagatg gagagatgga gccaccccaa       60

gagacaaata ggcctttcag cacacttgat aaccgcagcg ggcaggtcca agtcctgtcc      120

gccaccccgc tattgcagag gaatccctac agcagcccgg atatcatgca cattaaaggg      180

tcggaggctt cttcggtccc ttacgccctg aaccagggca cgacggccct gcctaagaac      240

aagaaccagg agggcaccgg gcaccggctg ctgaacatgc tgagaaaaac tcttaaagag      300

tctgatagtg aagaactgga aataacacag gagacgccaa atttggtgcc atttggggat      360

gtggttggct gcctgggcat tcatataaag aactgcagac attttatgcc taagatcagt      420

ttacaacatt atgctaattt attcattcgc atctctataa acaaagctgt gaaatgtaca      480

aaaatgtgta gcttgctatc caaaaacgat gagaagaaca ctgtaattaa gttcgatgaa      540

gtgaagtatt tttctgtaca ggttcccaga cgttatgatg ataagcggaa taatatttta      600

ttggaactca tacaatatga caatagagaa aaacgtgctt tcttgttagg gagtgttcag      660

atacatcttt atgaggtaat tcagaaaggg tgcttcattg aagaggtcca agtgttgcat      720

ggaaacatat ttgtctgcag gctggaggtg gaatttatgt tctcctatgg aaactttggt      780

tatggatttt cacatcagtt aaaacctctt cagaaaatta ctgagccatc catgtttatg      840

aatcttgcac cacctccaga aagaacagat cccgtgacaa aagttattac accacagaca      900

gtagaatatc cagcattctt atccccagac ctgaatgtta ctgttgggac tccagctgtg      960

caatcctcca accagccatc tgtagtgcga cttgaaaaac ttcagcaaca accccgggaa     1020

aggctggaaa agatgaaaaa agaatataga aatctgaata catggataga taaagctaac     1080

tatttagaaa gcattctaat gccaaaattg gaacataagg attctgagga aactaatata     1140

gatgaggcat ctgaaaacac gaaaagtaat catcctgaag aggagcttga aaatattgta     1200

ggagtagata tccctcttgt aaatgaggaa gctgaaacta ctgcaaatga gttactggat     1260

aatgattctg agaaaggcct gactatacca actttgaacc aatcggacca agataattca     1320

actgctgatg cttctaaaaa tgatgaatca acaccttcac ccacagaagt gcactcattg     1380

tgcactattt ctaaccagga aacaataaaa gcaggcagaa taccaccttt aggtgaacgt     1440

caatcagaaa gcatgccaga cagaaaaatg aaaaatgtat tttttccatt agaagtaaaa     1500

ttaaaagata actatccaag cattttaaaa gcagactcat ctctatcaga ggtggctttt     1560

tcaccaaaag aatataattc accatctttc agaccagaat atatagaatt caaaccaaaa     1620

tttcaggatt gttcagataa atttgaggat ttacatgaca tgacctcatt tacacacctt     1680

aaaaaagtaa aatcaagatc aaggctttta ggaaaaagct cagatgatat ccataaccat     1740

gccagacact ctgcaagacc atatactgct ccggaggtta acaagcaacg agaaagctac     1800

agtggaaagt ttacaagtcg tcgaatggtt tcatcaggct tagttcatat aaatgataaa     1860

acatcagatt atgaaatgca taaaatgcgg ccaaaaaaaa ttaaaagagg atattgaaaa     1920

atgttcgctc atttgtgata ttataaaaca tgtttaactc agaatgatat gtgaggccag     1980

cagtcagaat atcacttctc cattaacaaa atggtttgga gatctcttct tttgtgtgac     2040

agaagtcagc aaccaaattt catcttgtta gaaccatttt gttttgatta aaatgaaaaa     2100

caaa                                                                  2104


<210> 583
<211> 5976
<212> DNA
<213> Homo sapiens

<400> 583
cacaggaaat aagcaatgga ggtggggtcc tttgctcgcg ccgaaattca aaggaataaa       60

tagttccggc gcgggtgttg agagcggtgt ggcaggtgtt gtagccgcta tggtgaagtt      120

cgctttgtag cggccccggc tagagagttg ttctgttccc tgcctttgtg acccggagga      180

gcttttgggg tgcgtcaagc ccctggcctg aggcagcggt gaggcgtaac tggtttgtgg      240

cctgtttgat tcctgtcaga ggtttgctga cccaagacag tatcgaaaat gcatattaag      300

tcaattattc tagagggatt caagtcctat gctcagagga ccgaagtcaa tggttttgac      360

cccctcttca atgctatcac tggcttaaat ggtagtggga aatccaacat attggactcc      420

atctgctttt tgctgggcat ctccaacctg tctcaggttc gggcttctaa tttacaagat      480

ttagtttaca aaaatgggca ggctggtatt accaaagcct ctgtgtcaat cacttttgat      540

aattctgaca aaaagcaaag tcctttagga tttgaggttc atgatgaaat cacagtaaca      600

aggcaggtgg ttattggtgg tagaaataaa tatttaatca atggagtcaa tgccaacaac      660

accagagtac aggatctctt ctgttctgtt ggccttaatg ttaacaaccc tcactttctc      720

atcatgcagg gccgaattac aaaagtattg aatatgaaac ctccagagat tttatccatg      780

atagaagaag cagctggaac caggatgtat gaatacaaaa aaatagctgc acagaaaact      840

atagaaaaaa aggaggctaa gctgaaagaa attaagacga tacttgaaga agagattact      900

ccaaccattc aaaaattaaa agaggaaaga tcgtcctact tggagtacca aaaagtaatg      960

agagaaatag aacatttgag tcgtttatat attgcttatc agtttttgct ggctgaagat     1020

accaaagtac gctcagctga ggaattaaaa gaaatgcaag ataaagttat aaagcttcag     1080

gaagaattgt ctgagaatga taaaaaaata aaagcactta atcatgaaat agaagaattg     1140

gaaaaaagaa aagataagga aactggaggt atacttcgat ctttagaaga tgctcttgca     1200

gaggctcagc gagttaatac taaatctcaa agcgcatttg atctcaagaa gaaaaatctg     1260

gcatgtgagg aaagcaaacg caaagagctg gaaaaaaata tggttgagga ctcaaaaact     1320

ttagcagcaa aggaaaaaga ggttaaaaag ataacagatg gactgcatgc ccttcaagaa     1380

gcaagtaata aagatgctga agctctggca gctgcacagc agcacttcaa tgctgtttcc     1440

gctggcctgt ccagtaatga agatggagca gaagcaactc ttgctggtca aatgatggcc     1500

tgtaaaaatg atataagtaa agctcagaca gaagccaaac aggctcagat gaagttgaag     1560

catgctcaac aggaattaaa gaataaacaa gctgaagtta agaagatgga tagtggctac     1620

aggaaggatc aagaagctct agaagctgta aaaagactta aagaaaaact tgaagctgaa     1680

atgaaaaagc taaattatga agaaaataaa gaggaaagcc ttttggaaaa gcgcaggcag     1740

ctgtctcgtg atattggtag attgaaagaa acatatgaag ctctattagc cagatttccc     1800

aatcttcgat ttgcatacaa ggatccagag aagaactgga atagaaattg tgtgaaagga     1860

cttgtggctt ctctgattag tgtgaaagac acttctgcaa ccacagcttt agaattagtg     1920

gctggagaac gactctacaa tgttgtagta gacacagaag ttactggtaa aaagctacta     1980

gaaagggggg aactgaaacg tcgatacact ataattccac tcaataaaat ttcagccaga     2040

tgtattgcac cagaaactct gagagttgct cagaatcttg ttggccctga caacgttcat     2100

gtggctcttt ccttggttga atataaacca gaacttcaga aagcaatgga gtttgtcttt     2160

ggaacaacat ttgtttgtga caatatggat aatgccaaaa aagtggcctt tgataagagg     2220

ataatgacta gaactgtaac tctcggaggt gatgtgtttg atcctcatgg gacattgagt     2280

ggaggtgctc gatcccaggc agcttccatt ttaaccaagt ttcaagaact caaagatgtt     2340

caggatgaac tgagaatcaa agagaatgag ctgcgggctc tagaagagga attagcaggt     2400

cttaaaaaca ctgctgaaaa gtatcgccaa ctaaaacagc agtgggagat gaaaactgaa     2460

gaggcagatt tattacaaac caagctccag caaagctcat atcacaagca acaagaagaa     2520

ttagatgccc ttaaaaaaac cattgaggaa agtgaggaga ctttgaaaaa cactaaagaa     2580

atccaaagaa aagcagaaga aaaatatgaa gtattggaaa ataaaatgaa aaatgcagaa     2640

gctgaaagag agcgagaact gaaagatgct cagaaaaaac tggattgtgc caaaacaaag     2700

gcagatgcat ctagcaagaa gatgaaagaa aaacaacagg aagttgaagc tatcactctg     2760

gaactggaag agctcaagag agagcataca tcttacaaac aacagcttga agctgtaaat     2820

gaagctatca aatcctatga aagtcagatt gaagtaatgg cagctgaggt ggctaaaaat     2880

aaggagtcag taaataaagc tcaagaagag gtgaccaagc aaaaagaggt gataacagcc     2940

caagacactg taattaaagc taaatatgca gaagtggcaa aacacaagga gcaaaacaat     3000

gattctcagc ttaaaattaa ggaattagac cacaacatca gcaaacataa acgggaggct     3060

gaagatggtg ctgcaaaggt atccaaaatg ttgaaagatt atgactggat taatgcagag     3120

agacacctct ttggccaacc caatagtgcc tatgatttca aaactaacaa ccctaaagaa     3180

gctggtcaga gacttcagaa gttgcaagaa atgaaggaga aactaggaag aaatgtcaat     3240

atgagagcta tgaatgtatt gacagaagct gaagagcgat acaatgactt gatgaagaag     3300

aagagaattg tagaaaatga caaatccaaa attcttacaa ctatagaaga ccttgaccag     3360

aagaaaaacc aagccctaaa tattgcatgg caaaaggtga acaaggactt tgggtctatt     3420

ttttctactc ttttgcctgg tgctaatgct atgcttgcac caccagaggg tcaaactgtt     3480

ttggatggtc tggagttcaa ggttgccttg ggaaatacct ggaaagaaaa cctaactgaa     3540

cttagtggtg gtcagaggtc tttagtggcc ttgtcattaa tactgtccat gcttctcttc     3600

aaacctgctc caatttatat ccttgatgag gtagatgcag ccttggatct ttctcatacc     3660

caaaacattg gacagatgct gcgtactcat ttcacacatt ctcagttcat tgtggtgtca     3720

ctaaaagaag gtatgttcaa caatgcaaac gttcttttca aaaccaagtt tgtggatggt     3780

gtttctacag tagccagatt tactcaatgt caaaatggaa agatttcaaa ggaagcaaaa     3840

tccaaggcaa aaccacccaa aggagcacat gtggaagttt aaactacaaa gttatttctt     3900

catcttgacc tgttttttta aatgtaaact tttaaggact tgagataact aatttgttta     3960

tatacaaaaa ttaatgttac tgtgttactt aacccatgtt ttctctttat ataatcactt     4020

atcgcttaca aatgagcata tattcctcat ctcttaacta gtctaattat ggtccaatta     4080

ttgtggttgt gattttatgc atatcatcaa atgttttttt cttatgcggg tcttttatat     4140

attagggatc ctgagatacc cgattctata tgtaaaagct aatatacaaa aaagcagatt     4200

aaattacatg ataaatgtag ctgatcatca gtgtttaatt gatttaattc ctaaggcaat     4260

attaatgtgt tttctaaagt cattcaggta aggaagaatt ataaatcagg taactggacc     4320

aacaaaggga acacatataa agctattatg catgcatgga gccgtttgag gctagttttt     4380

taaggccaca actccagacc cctgatttag actgagatag gaaacagatc ttgaaagaat     4440

ccttatttta atgatacatg aatatcatgt tcctatacgc ttaataattg gtctctacgt     4500

tttaatgata catgaatatc atgttcctat acgcttaata attggtctct acgactttaa     4560

tgtttttgtt tttttaagct gtgtaagtat ttttaaatca aagcttagga ggtgtgttgc     4620

gtggtactat ctgctgcaaa tttatctgaa gtttgttaat attttccaag atttttgtca     4680

gccttttcat aatccagtca ttaacaacct attggtaaac aagaatgtag gtgccagtag     4740

actaaaccaa atttattttt ccctgagtct gatatatata tgtataaata taaataactc     4800

aatccatctg ttccaccaaa ataactcaaa agttggatga ttatttgtct tccgctttcc     4860

agttcaaagg gatgaaattc ctttagaact tgaaagatga cactagcgaa caccatgaga     4920

atactgtcta cagtttttgg tacgtcatca ctagaacagt gaccccaaac tgaatcatga     4980

aaggtctgac atgatgtaat ctgatcttcc atgtgttatt ttggccccac atctcttctt     5040

gattttttag tcttatttcc ttagtgttat tatcatactt cccctgatat atggccgtac     5100

ttcctggccc tgggcttgac atttcccacc cttcattctc catacatatg agatgtcaga     5160

aaacatgcag taattgatat tatgggacac attggaaagg attgaatctg gaattagttc     5220

tgtccactgt ggaggggaga ggaaataatg ctgtaaatgt tgagttacag aaagtccaat     5280

gtcaaatata gtttttttgt ttcctttcaa atgtattaca gactgtgcca aaacagttac     5340

caattcacac tgtcaatatt aaagtatacc atagtataca aattagtcag tacttgctgt     5400

taattttaat atttctgatt taacagttag ttattaagtg gtacttcatt gctgttttag     5460

ccaacgtttt aaaaataatt tgggagtttg actattttgg cttacgtact catttccttt     5520

tctctgctaa aaatgttttg cttgtgtgcg ttcctgattt ttgtcttgta taatcttgat     5580

ctttgaaaac cctcaaacat gtattaaatt gttgtaactt tttttcatta gagggaagac     5640

attaagggga ttggggacat ttgtttcaca catctgcagt aatatgagtt aactaatatt     5700

taacaagctc tttctttaca ttagctgctg ttctcatttg tatgtattgt catatttaat     5760

cctcagagta acctagtgag gtaaatactg ttgttgtcag catggtgtaa tcgaggaatt     5820

gagtgagttg agcagaaaag ttaggaaact tgctcagggt gataatacag ttaggagtgt     5880

cagggcccat ggacaaatct tgtcagtctc cagaacctaa gatatactac gtcactgaca     5940

gcttgaacat ttgtatttat tgtacagaat aaattt                               5976


<210> 584
<211> 1897
<212> DNA
<213> Homo sapiens

<400> 584
tccagcgatc gcagcccagc cccagctcct cctcctccac ggcttacccg ggctccgaca       60

gcggctgcag gtctccaagt tgcggccgct ggagcccgag ccatgcggac cgcggaccgg      120

gaggcgcgcc cggggcttcc gtccctgctg ctgctgctgc tggccggggc cgggctgtca      180

gccgcctcgc ccccagcagc gccgcgcttc aacgtgagcc tggactcggt ccccgagctg      240

cgctggctgc ccgtgctgcg gcactacgac ttggacttgg tgcgcgccgc gatggcgcaa      300

gtcatcgggg acagagtccc caagtgggtg cacgtgttaa tcggaaaagt ggtcctggag      360

ctggagcgct tcctgcccca gcccttcacc ggcgagatcc gcggcatgtg tgacttcatg      420

aacctcagcc tggcggactg ccttctggtc aacctggcct acgagtcctc cgtgttctgc      480

accagtattg tggctcaaga ctccagaggc cacatttacc atggtcggaa tttggattat      540

ccttttggga atgtcttacg caagctgaca gtggatgtgc aattcttaaa gaatgggcag      600

attgcattca caggaactac ttttattggc tatgtaggat tatggactgg ccagagccca      660

cacaagttta cagtttctgg tgatgaacga gataaaggct ggtggtggga gaatgctatc      720

gctgccctgt ttcggagaca cattcccgtc agctggctga tccgcgctac cctgagtgag      780

tcggaaaact tcgaagcagc tgttggcaag ttggccaaga ctccccttat tgctgatgtt      840

tattacattg ttggtggcac gtccccccgg gagggggtgg tcatcacgag gaacagagat      900

ggcccagcag acatttggcc tctagatcct ttgaatggag cgtggttccg agttgagaca      960

aattacgacc actggaagcc agcacccaag gaagatgacc ggagaacatc tgccatcaag     1020

gcccttaatg ctacaggaca agcaaacctc agcctggagg cacttttcca gattttgtcg     1080

gtggttccag tttataacaa cttcacaatt tatactacgg taatgagcgc cggtagccca     1140

gacaagtaca tgactaggat cagaaacccg agtagaaagt aagtcagcag aagagcgagt     1200

tcgcccgtgc tgtgaaagat gattttttaa aaaatgaaat tcttgaagag ctgcacctta     1260

aaaaataaga caaagtgaaa gtattgtatt atgttacaaa caatgcaggc tccttcctca     1320

tttaacttta caaccttgcg aagtgggtcc aggagatttg gagtttgtgg taaagccagt     1380

aatgggcatt gtcctgcatt cccttccctt catggtttgc ctcgatcctc tctaagcttc     1440

tatcctggcc tgaataactc aaagataatt ggtctcagag atcaagccat atcctcaggc     1500

cttatttcca tcttctcatg attctgccat catacctttg cttctccgct aatgaaatga     1560

gctggcaaga cctctgttca ttgtgaagtg cttctgaaag agcctaagaa aaaaggctca     1620

tctgaaagaa atggagaact ctatttcgaa ccaagcctgt ttgaatgtgt gttagtctga     1680

tctttgatca tgtgtttcca tgtaatggga gtctcgtttt ttataatgtt tctaacgttt     1740

tattgaaaaa cctatggccc tccttctttc tcaatagcta ctttcttact gctttttgaa     1800

aataatatgc aaccaaatta tttcttaatg tcacataatt aagtaataaa atgtcaaaag     1860

aaatgttggc aaggagaata aaaaaatttc caagaaa                              1897


<210> 585
<211> 2005
<212> DNA
<213> Homo sapiens

<400> 585
gatcggggat cgtcagcttg gttctggcca cagaggttgc tcttctcgcg atgcttcaga       60

cctggcggca gggaaagggt gggctaattg gagagccagg aagagcgtga ggcggcccca      120

cgctgctttc ccagaaggct gtgcgtgctc ctcgcttcct ccgcggtctt ccgagcggtc      180

gcgtgaactg cttcctgcag gctggccatg gcgcttcacg ttcccaaggc tccgggcttt      240

gcccagatgc tcaaggaggg agcgaaacac ttttcaggat tagaagaggc tgtgtataga      300

aacatacaag cttgcaagga gcttgcccaa accactcgta cagcatatgg accaaatgga      360

atgaacaaaa tggttatcaa ccacttggag aagttgtttg tgacaaacga tgcagcaact      420

attttaagag aactagaagt acagcatcct gctgcaaaaa tgattgtaat ggcttctcat      480

atgcaagagc aagaagttgg agatggcaca aactttgttc tggtatttgc tggagctctc      540

ctggaattag ctgaagaact tctgaggatt ggcctgtcag tttcagaggt catagaaggt      600

tatgaaatag cctgcagaaa agctcatgag attcttccta atttggtatg ttgttctgca      660

aaaaaccttc gagatattga tgaagtctca tctctacttc gtacctccat aatgagtaaa      720

caatatggta atgaagtatt tctggccaag cttattgctc aggcatgcgt atctattttt      780

cctgattccg gccatttcaa tgttgataac atcagagttt gtaaaattct gggctctggt      840

atcagttcct cttcagtatt gcatggcatg gtttttaaga aggaaaccga aggtgatgta      900

acatctgtca aagatgcaaa aatagcagtg tactcttgtc cttttgatgg catgataaca      960

gaaactaagg gaacagtgtt gataaagact gctgaagaat tgatgaattt tagtaaggga     1020

gaagaaaacc tcatggatgc acaagtcaaa gctattgctg atactggtgc aaatgtcgta     1080

gtaacaggtg gcaaagtggc agacatggct cttcattatg caaataaata taatatcatg     1140

ttagtgaggc taaactcaaa atgggatctc cgaagacttt gtaaaactgt tggtgctaca     1200

gctcttccta gattgacacc tcctgtcctt gaagaaatgg gacactgtga cagtgtttac     1260

ctctcagaag ttggagatac tcaggtggtg gtttttaagc atgaaaagga agatggcgcc     1320

atttctacca tagtacttcg aggctctaca gacaatctga tggatgacat agaaagggca     1380

gtagacgatg gtgttaatac tttcaaagtt cttacaaggg ataaacgtct tgtacccgga     1440

ggtggagcaa cagaaattga attagccaaa cagatcacat catatggaga gacatgtcct     1500

ggacttgaac agtatgctat taagaagttt gctgaggcat ttgaagctat tccccgcgca     1560

ctggcagaaa actctggagt taaggccaat gaagtaatct ctaaacttta tgcagtacat     1620

caagaaggaa ataaaaacgt tggattagat attgaggctg aagtccctgc tgtaaaggac     1680

atgctggaag ctggtattct agatacttac ctgggaaaat attgggctat caaactcgct     1740

actaatgctg cagtcactgt acttagagtg gatcagatca tcatggcaaa accagctggt     1800

gggcccaagc ctccaagtgg gaagaaagac tgggatgatg accaaaatga ttgaaattgg     1860

cttaattttt actgtaggtg aaggctgtat ttgtagtagt actcaagaat cacctgatgt     1920

tttcttattc tccttaaatt aagagttatt ttgtgtttgt attcttggct ggatgttata     1980

ataaacatat tgttactgtc aaagc                                           2005


<210> 586
<211> 2014
<212> DNA
<213> Homo sapiens

<400> 586
atcttttcca tctcctgctc cttccgcctt cccgccatcc gccctccaca cgattcagcc       60

cggtggtgtt agccccctgg actcgattcc tgaggcaaac agtgcccctt aaggtcggcg      120

acagcctctt ctgggttcac tgcagtccaa ccggttccct accctctgcc attatgaaca      180

tccgcaacgc tcagccagac gacctgatga atatgcaaca ctgcaacctc ctttgccttc      240

ctgagaacta ccagatgaaa tactatttat atcatggcct ttcctggccc cagctttctt      300

acatcgctga ggatgaggac gggaagattg tgggctatgt tctggccaaa atggaggagg      360

aaccagatga tgtcccgcat ggccatatca cctcactggc cgtgaagcgt tcacaccggc      420

gcctcggcct ggcccagaag ctgatggacc aggcctccag ggccatgata gagaacttta      480

acgccaaata cgtgtctctg cacgtcagga agagtaaccg gccagccttg cacctttatt      540

ctaacaccct caactttcag attagtgagg tggaacctaa atactatgca gatggggaag      600

atgcttatgc tatgaagcgg gatctctcgc agatggcaga tgagctgaga cgacaaatgg      660

acctgaagaa gggcgggtat gtggtcctgg gctccaggga gaaccaggag acccagggca      720

gcacactttc tgattctgaa gaggcctgtc agcaaaagaa cccggctacc gaagaaagtg      780

gcagtgacag caaagaacct aaggagtctg tggagagcac caacgtccag gacagctcag      840

aaagctcgga ttccacctcc tagagcatgc ttaagcattt caggtcctca tgtctcaacc      900

acatctactc tgtgaaccct ggcttagtct gtctgctctg cagcatctgc tgtggggatc      960

atctcacagt gaccagaatg gcttctcact cttaactcta taaacaacca cctttcacat     1020

atcctgctgg gatcatgaag gaatacctgg acacaagagc cactgcacaa cagccaagga     1080

actttgagac ctgccattac agaacctttc ttggcctact cacactacgc tgccatttta     1140

ttctgtttgt agtagtcctc tgttgggtgt ggttatcctg caagtttttc tccttttaga     1200

atgatgaaca ggaagcaggg caaactcttg aagatttcca gctttcagtt tttgtttttg     1260

ttttttaacc attatttacc tgagttttca tccttgagga ggtgaagtag tcaggaccat     1320

gaagtcagac ctcatgccct cttcctcctc tttcctggaa gaagtattca gtttcctttt     1380

cctttctctg gtaactcctc ctttatacta ttcccccctc cctttttttt gaggaggagg     1440

gcatcacctt cccagtggga aaaggtgtta agttaggagc ttctactgta caatcagaac     1500

ttggagattt taagaaaagg acaaacggta attaaattgg aatctctaat gtgcttgttt     1560

gtgttagttt ttttgtgatt atgtcacttg gcatttattg agtacctgca gtgttcacac     1620

acaatgctgg agccttcatt agttacatat ttaaccctct cagcaaccct gtaaagtagg     1680

tagtattatc cctgttttac agatgaggaa actgaagctc agagaagtga attaaatatc     1740

ctggatctga acccaattct gtttgaattc aaagccaaag ttccttctac ttttctgttc     1800

ctactctttg cattttattt ataaatgtgt taaaatttta gcaaaaatgg agaatctgct     1860

gtttaaaaat gtgtttgctt aatacatggc tactgtatgt caattgtaaa tatttatata     1920

acctacaatt ataatctatt tttattattt ttctctagta aaaataagtg aagacaaagt     1980

accttgacct ctgcagtaaa agttaccaga taaa                                 2014


<210> 587
<211> 4453
<212> DNA
<213> Homo sapiens

<400> 587
aactccattg gataaatggc gaggaaacgt atactccctc ttaaggaaca cggtgtcttc       60

cttcgtctcc gggttcccga gaccccagag tcactgacct ccgtccctca gctttcgggg      120

ttcggcagca gaaggggcgg gcccgggcct gggattggct ggcgtcgtcc gacccccttc      180

gctgctctcc attcgcaatc gcccgcgggc gcctgcgcga tgggtcggcc gtggggagcg      240

gggcgggaag cgcttcaggg cagcggatcc catgtcggcc ctgaggcgct cgggctacgg      300

ccccagtgac ggtccgtcct acggccgcta ctacgggcct gggggtggag atgtgccggt      360

acacccacct ccacccttat atcctcttcg ccctgaacct ccccagcctc ccatttcctg      420

gcgggtgcgc gggggcggcc cggcggagac cacctggctg ggagaaggcg gaggaggcga      480

tggctactat ccctcgggag gcgcctggcc agagcctggt cgagccggag gaagccacca      540

ggagcagcca ccatatccta gctacaattc taactattgg aattctactg cgagatctag      600

ggctccttac ccaagtacat atcctgtaag accagaattg caaggccaga gtttgaattc      660

ttatacaaat ggagcgtatg gtccaacata ccccccaggc cctggggcaa atactgcctc      720

atactcaggg gcttattatg cacctggtta tactcagacc agttactcca cagaagttcc      780

aagtacttac cgttcatctg gcaacagccc aactccagtc tctcgttgga tctatcccca      840

gcaggactgt cagactgaag caccccctct tagggggcag gttccaggat atccgccttc      900

acagaaccct ggaatgaccc tgccccatta tccttatgga gatggtaatc gtagtgttcc      960

acaatcagga ccgactgtac gaccacaaga agatgcgtgg gcttctcctg gtgcttatgg     1020

aatgggtggc cgttatccct ggccttcatc agcgccctca gcaccacccg gcaatctcta     1080

catgactgaa agtacttcac catggcctag cagtggctct ccccagtcac ccccttcacc     1140

cccagtccag cagcccaagg attcttcata cccctatagc caatcagatc aaagcatgaa     1200

ccggcacaac tttccttgca gtgtccatca gtacgaatcc tcggggacag tgaacaatga     1260

tgattcagat cttttggatt cccaagtcca gtatagtgct gagcctcagc tgtatggtaa     1320

tgccaccagt gaccatccca acaatcaaga tcaaagtagc agtcttcctg aagaatgtgt     1380

accttcagat gaaagtactc ctccgagtat taaaaaaatc atacatgtgc tggagaaggt     1440

ccagtatctt gaacaagaag tagaagaatt tgtaggaaaa aagacagaca aagcatactg     1500

gcttctggaa gaaatgctaa ccaaggaact tttggaactg gattcagttg aaactggggg     1560

ccaggactct gtacggcagg ccagaaaaga ggctgtttgt aagattcagg ccatactgga     1620

aaaattagaa aaaaaaggat tatgaaagga tttagaacaa agtggaagcc tgttactaac     1680

ttgaccaaag aacacttgat ttggttaatt accctctttt tgaaatgcct gttgatgaca     1740

agaagcaata cattccagct ttcctttgat tttatacttg aaaaactggc aaaggaatgg     1800

aagaatattt tagtcatgag ttgttttcag ttttcagacg aatgaatgta ataggaaact     1860

atggagttac caatattgcc aagtagactc actccttaaa aaatttatgg atatctacaa     1920

gctgcttctt accagcagga gggaaacaca cttcacacaa caggcttatc agaaacctac     1980

cagatgaaac tggatataat ctgagacaaa caggatgtgt ttttttaaac atctggatat     2040

cttgtcacat ttttgtacat tgtgactgct ttcaacatat acttcatgtg taattatagc     2100

ttagacttta gccttcttgg acttctgttt tgttttgtta tttgcagttt acaaatatag     2160

tattattctc tacttcttgg tacattttgt agtaatatgt ttaatataat tattcaagag     2220

actatattga cagccagata gtatggcagt tctgaaaaaa tttatatctt ttcaccactt     2280

gaatatactg caatgtgtag tgagtaaatt gtctcccttt ttctatagat cattaggtta     2340

gagttttttt cttctttttt tttttttttt ttttttacca cttctgctgt tcatggtagt     2400

agtggaaggt aaatttggaa atggcattga cataaaatga aaatgtttac ggacactttt     2460

cttttttgct tttttattgt atttggataa agatccactt aaaagttatc tgttttttcc     2520

tgtttttttt ttttttcccc aaagtgtagt tatgttttca ctattgctgc ttctatagag     2580

ggcattgtga tagagagtta cagatgaaac attaaatgcc acagtgagta gaaataatta     2640

ctacaaaaag taataaatat gattacttgg taatatcatt ctccatctaa aatactagtt     2700

tcacctgtga gcagatttca gctcagttta tagttaaaaa caatgagggt aaaatgggat     2760

tcatgctcag ggaatgaatc agccatagtt agagtgggaa attattattt tcttcattta     2820

aaggtagatt ttatgtttat ttccctaaat tgcataagat aaaattgtct gtttaataaa     2880

aagacattta ttaccattat taacagtcat tttagagcca aatttaagaa aaggatattg     2940

aaagggtctt tattggcctt gtttgggtaa ctctatgctg ttagatagaa gagacttagg     3000

taaataactt tttatgtctg aggtgagtac acaatattgg ttcttggaaa aatagctgtt     3060

tcttcataag atacccaagt gataattttt tttcccctag actgtcaggc ctatgagtaa     3120

atactaaatc tattagctgt ccccactcat aaaccaaacc aaaccaatac aaacagatga     3180

ggagaggaaa tgtagtaaaa atactggctg ggtcttatga ttgggatgag tgattttata     3240

agataatatg gtgataattt tattctagga ttttattttt ggcctaatat aggaatgttt     3300

aaaaaaggct tttctatgaa aattagaaat ttatacttga aattaaaagt ctagaagggg     3360

gaggacctta aagctaagct accagtaaga caatgaataa ttcagaagag aacactattc     3420

ttttactgac tgagtgccca agatgccaat ttccatgaag tcttgattta tatatatgta     3480

cacatgttat gcacatacat gtttgttttc taacagttat tttttaagct tttgagataa     3540

ttttagactt acagaagagt tgtaaaagta gtagagttct tgtatactct gcacccacct     3600

tgcccttatg ttaacatctt acgtaacaat agaacatttg tcaaaattaa gaaattaacc     3660

ttgatataat actaactaaa gtagaaagtt taaaaagtag agattttagt cttttcacta     3720

atgtcctttt actgttccaa gacccagcct tgcatttagc tatcatgcct acgtcctgtc     3780

ttccagtctg tgacagtgta tcataacagg ggatacctga tgttgtaatg tatttctggt     3840

gttgttaacc ttgatcacta tgctaaggtg gtgtctgcta ggattcgcta ctgtaaactt     3900

actgtgtttt ccttgtaatt attgaatatt tgctggagat acccggagac tatgcaaatg     3960

tcccgtttct gcttaaactt ttgctcattt tactatccat tggcagatct tgcttgtggc     4020

agttactact gtggtgttct aatggtgatt ttctatttct ctcaatcctt ctacatttat     4080

tattggaatt cttctgtaag gaagagttgt cagttctgga tttatatttt taactataat     4140

aagatattca ggataagtat agatttagaa cttaaagatg ttaaatcatg ttaaaattat     4200

tccaaatacc aatatcaaag aaaactaagt tggtaatcta tctcagaaaa tatatgaact     4260

taagaaggaa aatagtattt atgatttgta gaattggttc aacttttgac ttaatactga     4320

ctttggactg aattcaaagt tttcttgaaa tttcacatct ggacttttta aagtgtctac     4380

atttatatta ctttggggat cattttgtca aagtcttgaa taaagttacc cagtcctggc     4440

atgataaaca caa                                                        4453


<210> 588
<211> 3502
<212> DNA
<213> Homo sapiens

<400> 588
aaatttcccg ggccgggagc gctgggcctg ccgggaaggc gctgggacgg ttacccagcg       60

ggccgccggc ggtcgtgggc aagcttcgcc atgcagagca ctgacctagg caacaaggag      120

agcggcaaga tatggcaccg caagccgtcc ccggccacgc gggacggaat tatagtgaac      180

attattcaca acacttccga ttaccatcca aaagttttgc gatttttgaa tgtggctttt      240

gatggcacag gcgactgctt aattgctggg gaccaccaag gaaatattta tgtttttgac      300

ttacatggaa acaggttcaa tcttgttcag cgaacagcac aagcttgcac agctctggcc      360

tttaatcttc gtaggaaatc tgaattcctt gtggcattag ctgattattc tattaaatgt      420

tttgatacag tcaccaagga gctagttagc tggatgagag gacatgaatc atcagtattt      480

tcgatctctg tgcatgcatc agggaaatat gccatcacaa cttcttctga tacagcacaa      540

ttatgggact tggatacctt tcagagaaaa agaaagctga atattcgcca gtctgtgggt      600

atacagaagg ttttctttct accattaagt aataccatcc tcagctgttt taaagataat      660

tccatttttg cctgggaatg tgacacactt ttttgcaaat atcaattgcc agctccacct      720

gaaagctcta gtatattata caaagtgttt gctgtaacca gagatggccg aatcctggct      780

gctggaggca agtcaaatca tcttcatttg tggtgcttgg aagctaggca gctctttaga      840

attatccaga tgcccactaa agttcgagcc attcgccatc tggaatttct tcctgatagt      900

tttgatgctg gttctaatca ggttcttgga gtactaagtc aagatggtat tatgagattt      960

atcaatatgc agacttgtaa acttctcttt gagattggga gcctcgatga aggaattagc     1020

tcatcagcaa ttagcccaca tggacggtac attgcatcta ttatggaaaa tggaagtcta     1080

aacatatatt cagttcaggc tttaacacaa gaaataaata agccacctcc gcctttagtg     1140

aaagttattg aagatttgcc caagaataaa ctgagttcca gtgatcttaa gatgaaagta     1200

acatcaggga gagtacagca gccagcaaaa tctagggaaa gcaaaatgca aactagaata     1260

ttaaaacaag acctgactgg tgattttgaa agtaaaaaga atgaattacc agatggatta     1320

aacaaaaagc gtttacaaat cttattaaaa ggctatggtg aatatccaac aaaatacaga     1380

atgttcattt ggcgctctct gctacaactg cctgaaaatc atactgcgtt tagtaccctc     1440

atagataagg ggactcatgt ggcatttctc aaccttcaga agaaataccc catcaaaagt     1500

aggaagctac tcagagtatt acagagaacc ttatctgcat tagctcactg gtctgtcatt     1560

tttagtgaca caccatatct tccactcttg gcatttccat ttgtaaaatt attccagaac     1620

aaccaactca tctgttttga agttattgct actctcataa tcaattggtg tcaacactgg     1680

tttgaatatt ttcctaatcc tcctatcaat attcttagca tgatagaaaa tgttttggca     1740

tttcatgaca aggaactgct gcaacacttc atagatcatg atataacctc ccagctatat     1800

gcatggcctc ttcttgaaac tgtgttctca gaagtgctga caagagagga gtggctgaaa     1860

ttgttcgata atatcttttc caaccatcct tccttccttc tgatgactgt tgtagcctac     1920

aacatatgtt ctagaacgcc tctgctcagc tgtaatctta aagatgactt tgagtttttt     1980

tttcaccatc ggaataacct ggatataaat gttgtgatta gacaagttta tcatctcatg     2040

gagaccacgc ctactgacat tcatccagac agcatgctta atgtttttgt tgcactgaca     2100

aaagggcagt atccagtatt taatcaatat ccaaagttta ttgtggacta tcaaacacag     2160

gaacgagaaa gaataaggaa tgatgaattg gattacttaa gagagaggca gacagttgaa     2220

gatatgcaag ctaaagtcga ccagcaaaga gttgaagatg aagcttggta ccagaaacag     2280

gagctgcttc gtaaagctga agaaacaaga agagaaatgc tcttacaaga ggaggagaaa     2340

atgatacaac aaagacagag gctagctgct gtgaaaagag agctgaaagt aaaggaaatg     2400

cacttacaag atgctgcaag aaggcgtttt ctgaagcttc agcaagatca acaggaaatg     2460

gaactaagaa gactggatga tgaaattggg agaaaggtat atatgagaga tcgagaaatt     2520

gctgccacag ccagagacct agaaatgaga cagctggaac tcgaatcaca aaagagactt     2580

tatgagaaga atcttactga aaatcaagaa gctcttgcaa aagaaatgcg agcagatgca     2640

gatgcctata gacgaaaagt ggatcttgaa gaacacatgt ttcataagct gatagaagca     2700

ggtgaaaccc agagccagaa aactcagaag gtgattaaag aaaatttggc aaaggctgaa     2760

caagcatgcc taaataccga ctggcagatt cagtctttac ataaacaaaa atgtgatgat     2820

ctacaacgaa acaaatgtta ccaggaagta gccaaactcc ttagggaaaa cagaaggaaa     2880

gaaatagaga taataaatgc aatggtggag gaggaagcca agaagtggaa ggaagctgaa     2940

ggaaaagagt tccgtttgag atcagcaaag aaagcttctg ctctttcaga tgcgtctaga     3000

aagtggtttt taaagcaaga gataaatgcg gctgtagaac atgctgaaaa tccatgtcat     3060

aaagaagaac ccaggttcca aaatgaacag gactcaagct gtttgcctag aacctcacaa     3120

ttaaatgact cttctgaaat ggatccctca acacagattt ctttaaatag aagagcagta     3180

gaatgggaca ccacgggaca gaatcttatt aagaaagtga gaaatcttcg ccagagactc     3240

actgcccggg ctcgtcacag atgtcaaacc cctcatcttt tggctgcata gaatgcatgt     3300

caccttgaga cggtcgagag agagacctat tttgcaatca gtgacattga tttttagatt     3360

atttatttaa aattcctata aagatcagcc ctttgtacag aaaaatgtgt ctataaaaat     3420

tatgtgttat ttaattctga tactttttgg cttgtaaatg gcttcttgaa ctttttacaa     3480

taaaaatgtt ttagaaactg tt                                              3502


<210> 589
<211> 1349
<212> DNA
<213> Homo sapiens

<400> 589
cctctccccc cgggctccgc ccaccccacg ccgggaaccc acgcgggcca ctacaagccc       60

gccctttcct acgtctggtc cagtcggtct tcctccggcc cgggccctgg cccagctagc      120

cggccatgga aggtaatggc cccgctgctg tccactacca gccggccagc cccccgcggg      180

acgcctgcgt ctacagcagc tgctactgtg aagaaaatat ttggaagctc tgtgaataca      240

tcaaaaacca tgaccagtat cctttagaag aatgttatgc tgtcttcata tctaatgaga      300

ggaagatgat acctatctgg aaacaacagg cgagacctgg agatggacct gtgatctggg      360

attaccatgt tgttttgctt catgtttcaa gtggaggaca gaacttcatt tatgatctcg      420

atactgtctt gccatttccc tgcctctttg acacttatgt agaagatgcc tttaagtctg      480

atgatgacat tcacccacag tttaggagga aatttagagt gatccgtgca gattcatatt      540

tgaagaactt tgcttctgac cgatctcaca tgaaagactc cagtgggaat tggagagagc      600

ctccgccgcc atatccctgc attgagactg gagattccaa aatgaacctg aacgatttca      660

tcagtatgga tcccaaggta ggatggggcg ccgtctacac actatccgaa tttacacatc      720

ggtttggcag taaaaactgc tgaacttggt ctcaagatgt ggaactgtgg agaaattcta      780

ggacatgaac aagctatcct ttcatcgagg acagcaaaca ttatggtaca gttggcttgg      840

aattatgtct ttctctttta atttgattga gtggaaatct gagtgaatac aaatataaat      900

gaacaacata aaaacttttg ttttgacatg tcaaattgaa acttgataaa gtgcgtactt      960

gctaagatat tcctgtggct catgcgttac aacacgagga cttaagccag taatcgtttt     1020

tgttcagata gaggtgtgga ggtagagcca gcccctcatg tctgttttgg atgttttgtg     1080

tctctccagc tacattgtaa gttccttgag ggcagggcca tggcccattg ctctgtgaat     1140

ctcaaatgcc cataaaaggt gcccataaaa tgttttcttg aacatttgaa tgtgctgttg     1200

tctggaaagg ggtaatattg tgagctgaat cagcaataag tattagtctt tttggactat     1260

ggtattgtta aaaagactgc agccctctca gacttgagcg ttaattggct tatttattta     1320

tggctttaaa taaaatcgat ttaacgtta                                       1349


<210> 590
<211> 3880
<212> DNA
<213> Homo sapiens

<400> 590
cccctcgttt ctccctcccc gcctcctccg cagaagccga gcgccaaact caaactttat       60

caggacccgg acctctcagg ctaatcccga gggccgggcc tgttgggctt ttctgcacac      120

cagccgaggc agcgagccaa catgagccaa gtgctgttcc accaactagt cccgttgcag      180

gtgaaatgca aagactgtga ggagaggaga gtaagtataa gaatgagcat tgaactacaa      240

tcagtttcta atccagttca cagaaaggac ttagttattc gtctgactga tgacacggat      300

ccattttttt tatataacct tgttatatct gaggaagatt ttcaaagttt aaaattccag      360

caaggtcttc tggtagactt cttagctttc ccacaaaaat ttatagatct ccttcagcaa      420

tgtactcaag aacatgccaa agaaattcca aggtttttgc tacagttagt ttctccagca      480

gctattttgg ataactcacc tgcattttta aatgtggtag agacaaatcc ttttaagcat      540

cttacacacc tctcactaaa acttttacct ggaaatgatg tggagataaa gaaatttctc      600

gcaggctgtt tgaaatgtag caaggaagaa aaattatcat tgatgcaatc actagatgat      660

gctactaagc aactggactt tacacgaaag acattagcag aaaaaaaaca agaattagat      720

aagttacgga atgaatgggc gtcacataca gcagccttga caaacaagca ttctcaggaa      780

ctgacaaatg aaaaggaaaa agccttgcag gcacaggttc aatatcaaca gcagcatgaa      840

caacagaaaa aagatttaga aatcctccat caacaaaaca tccaccagct acaaaacaga      900

ctgtctgagt tagaagcggc taataaagac ttaaccgaaa gaaaatataa aggagactcc      960

actattagag aacttaaagc aaaactttct ggtgttgaag aggagctaca gcggactaag     1020

caagaagtcc tctctttgcg aagagagaat tctacactag atgttgaatg ccacgagaaa     1080

gaaaagcacg ttaatcagct acaaacaaaa gtggcagttt tagaacagga aatcaaggat     1140

aaggaccagc ttgttttaag aacaaaagag gcatttgata caatccagga acaaaaggtg     1200

gttttagaag aaaatggtga gaaaaatcaa gtacaactag gaaagcttga agctacaata     1260

aaatcattat ctgcagaact tctgaaggca aatgaaatta tcaagaagtt acaaggggat     1320

ctgaaaactt taatgggtaa gttgaaattg aagaatacag ttactattca gcaagaaaaa     1380

ctcttggctg agaaggagga aaaattacaa aaggaacaaa aggaattaca agatgttgga     1440

cagtctcttc gaattaaaga gcaagaggta tgcaaattac aagaacaatt agaagctaca     1500

gttaaaaaac ttgaagaaag caaacaactt ctaaaaaata atgaaaagtt aatcacgtgg     1560

ttaaataaag aactaaatga aaatcagcta gtgagaaagc aagatgtatt gggaccttct     1620

actactccgc ctgcacattc cagcagcaac acaatcagaa gtggaatttc tcctaacctg     1680

aatgtggttg atggtagact gacttaccca acctgtggga ttggttatcc tgtctcctct     1740

gcatttgcat tccagaatac cttccctcat tcgatatctg ccaaaaatac cagccaccct     1800

ggttcaggaa caaaggttca gtttaatttg cagtttacaa aaccaaatgc atcactagga     1860

gatgttcagt caggagcaac tattagtatg ccttgctcaa ctgataagga aaatggtgaa     1920

aatgtagggt tggaatccaa atacctgaag aaaagggaag atagcattcc tttacgcgga     1980

ctcagccaga acctatttag taattcagac catcagagag atggcacttt aggagcatta     2040

catacatctt ccaaacccac agcgctcccc tctgcgtctt cagcctattt ccctgggcag     2100

ttaccaaaca gttaattcta gtgtcatgtt ttacttttta ttggtatttt agaaactcag     2160

gtgcttaaaa aatatgtcaa cacaaaccag atcctcaaat agcaagtttc aaattttact     2220

tgagctgtta aagactggat actttaagta ctgcttttat ggcagtttat aatataggaa     2280

caaatttgta cttggggatt ggtaaagatt gtgagtaaat gacatttttt ggtttgtgaa     2340

catggcgttt tatagaataa tatgaatttt attaagctat tctttagaaa ttcagttcta     2400

aggaaagagt tgatccttat gagggagatt ctgatcatat taaaaatctg ggtaaactaa     2460

aacctgctca taacctcata gtatgcaacc aaagaatact aattcatttt atcactttca     2520

ttggtaaaac ttttaaattc aacacctgaa aatcatgagg gaaaatgatt acctcttgag     2580

atatattatt gatgacattt aaagggaaaa gtcctaaatt taccttaaat aactgaaatg     2640

aattaagcct tcatagcgta ttttccttga agcatttaaa tttgctagtg atgaatcaaa     2700

taaatttgat atacttaaaa taatttggac agtttttatg tgaccagatt aagtgctttt     2760

gtcatttgag ctgacaagtt tttaaaactt cagtgcttcc taaatgttta tactcatcta     2820

gtttttctca atttgtagtt ttattatgca gttaaatctg tatcagtgga cttttaaaac     2880

ttggtactac tactaaatct actatatcat gaatattcat ttatttttat agtatcagaa     2940

cttgggttga tttcaatgtt aataaactag gcaaaacaaa taactgttag aaggtacaat     3000

tttcttctct tccctgtaac tgaaagtttt aagaattgtt ccttggggaa aaattttttt     3060

aaaattcacc tagaatcata gggcctcatt ttgttttctt attgacaaac aatacctggt     3120

agcattctct aaagagtctt ctagatcaat ttttataaag tactaatgct catgtgataa     3180

tttaaaatta ttttcaacta ctttattaca cagatgaaga aacatttcaa gatattgatg     3240

taataacatt actgagtccc atggtaagaa agaatctttg ctaatttttt tttttttttt     3300

acgaagccag tatcttgaaa ctattggcaa ttgcaagtgt ctttaaacta gggatctaat     3360

ctgaaaattc agtaactaat attaggcagt tgatactccc ccacctcccc catttagata     3420

cactactgta ttagtgagaa tacttggtac agtaacttga aagcacttgc tattctggaa     3480

agaagcctct tggtgatttt ggaaggagct ttattgtaaa tactatggaa ggggctttgt     3540

tgtaaatact atgtaatata tataaaatat tgtgacatgt tttggatggg atgcatgaca     3600

tacaggtagc tctctttttt aaaatatagg tatctctttg catatatata cacaaggaaa     3660

gttgaatttt caggagagat cattctgata tcttgcaaat ttgtattaaa tgtatacaga     3720

cttccaagtg tgctaattct ttacctccta aacttttagt tgcaattgtt ttgcagtgta     3780

aaattgtaca tgtgttaata atcaaaaagt gttgcattta atgttatttc tgtaaacttt     3840

gagctttgtt aataaactat tatgcagcat ctacactttg                           3880


<210> 591
<211> 1412
<212> DNA
<213> Homo sapiens

<400> 591
gccgggggtg ggaagaagac tgccactctc cgcccctacc tgagtgccgt gcgggccaca       60

ttgcaggctg ccctctgcct ggagaacttc tcctcccagg ttgtggaacg acacaacaag      120

ccggaagtgg aagtcaggag tagcaaagag ctcctgttac aacctgtgac catcagcagg      180

aatgagaagg aaaaggttct gattgagggc tccatcaact ctgtccgggt cagcattgct      240

gtgaaacagg ctgatgagat cgagaagatt ttgtgccaca agttcatgcg cttcatgatg      300

atgcgagcag agaacttctt tatccttcga aggaagcctg tggaggggta tgatatcagc      360

tttctgatca ccaacttcca cacagagcag atgtacaaac acaagttggt ggactttgtg      420

atccacttca tggaggagat tgacaaggag atcagtgaga tgaagctgtc agtcaatgcc      480

cgtgcccgca ttgtggctga agagttcctt aagaattttt aaaccatctg gctggatctc      540

gtggccttcc ccctcagact acccatgtct ccacgaaggc gtcctggagt cactccccga      600

gcagcgcggc ggcggcaggg agttgggttg gggtgggcat ttgatgcggg aggtgggtgg      660

tgtgcttgct agctgggcaa gaaagcagca gtggacctgc cccaaggcca cacgtgcctg      720

gtcaggctgg cttctgatgt tcagtcccct gggccgggac agattttttt taacgtcttg      780

aaacttaaac tctgtgcttg taggatactg taaccttttt gtcttttttt tttttttttt      840

ttttaaacct ccacctccag tggctgtgac tggtcccagt gattatacgt tattggttgc      900

tgtgggtctg ggcgggcctg gagccagaag gcgacttatt ttttctctcc tatgccaccc      960

caggtgggga gggagggagg tttcagactc cagtttctcc cttgcccttt tattcccaag     1020

cctccttggc cccagtataa gtgttgggaa ctctctgcca gcttcctgag ttctgcctaa     1080

agatggcccc ccagcactgg ttggggacaa gggccaaatt ggtgaccacc agtcatgcct     1140

aggacctggg gcccaaaagc cgggcaacct ctggctacag gggccattgg gtgccctccc     1200

agttgagagg ggccgctgtt tcgccttgtc cgtcagtgcc agtgcctgtg ccagaggtgg     1260

cgaggtgagt cctccagagc ttcctggccg ggccctcctc ctgcctgttc tggctcctct     1320

gctcccacgc tagctgtccc ttttctgatt ctggtggatc ctccctcccc taattaaagt     1380

ctctttttgc ccctttgggg ctgcatgagg tc                                   1412


<210> 592
<211> 1204
<212> DNA
<213> Homo sapiens

<400> 592
gcgcggcccg aggggcgggg gcggcgggcg gcccggggct gcaaagcggg gggccgccgc       60

ctccctgggc ctgcctgggc ggccgcctcc gcgatgccgc tgctcgtcga ggggcggcga      120

gtgcggctgc cgcagtcagc cggggacctc gtccgagccc acccgccttt ggaggaaaga      180

gccagacttc tcagaggtca gtctgttcaa caagtgggac cccagggcct tctgtatgtt      240

cagcaaagag agcttgcagt gacctcccca aaggatggct ccatctccat tctgggttct      300

gatgatgcca ctacttgtca cattgtggtc ctgaggcaca caggtaatgg ggccacctgc      360

ttgacacatt gtgacggaac cgacaccaaa gctgaggtcc ccttgatcat gaactccata      420

aaatcctttt ctgaccacgc tcaatgtgga aggctggaag tacaccttgt tggaggcttc      480

agtgacgaca ggcagttgtc acaaaaactc actcatcaac ttcttagtga atttgacagg      540

caagaagatg acattcactt agtgacatta tgtgtgacag aattaaatga ccgggaagaa      600

aacgaaaacc actttccagt aatatatggc attgctgtca acattaagac tgcagagatt      660

tacagagcat cctttcaaga tcggggtccg gaggagcagc ttcgtgctgc gcgaacttta      720

gcaggaggac caatgattag catttatgat gcagagacag aacaacttcg tataggaccg      780

tactcctgga caccatttcc acatgtggat ttctggttgc accaagatga caagcaaata      840

ctagagaatc tttccacttc gcctctggct gagccacccc actttgttga acatattaga      900

tctaccttga tgtttttaaa aaaacaccca tctccagctc acacactgtt ttctggaaat      960

aaagccctac tctacaaaaa aaatgaagat ggcttgtggg aaaagatctc ttctccagga     1020

agttaaaaaa catgaattac caaagaaagc accttcttgg cctgacagac cattggtggg     1080

gctggcacga atccagatct ggatcctaca tctgttgggt cttaggcctc cttccctcct     1140

cagtgtcttt caaatgactt tcatcaaatg actttcaaaa taaaacctta ttttggcaaa     1200

ggca                                                                  1204


<210> 593
<211> 5663
<212> DNA
<213> Homo sapiens

<400> 593
ataaactcta aggaagacag tgatggagtg aagtgggctg ggggcgatag agaggatggg       60

gtggggcacc aggcgagaga tgcgaaggaa gccagaacga aaagagagcg accgaggaga      120

gaagagagca gagcaataca aaagcagcct cggatctagc cggagctgca agcgttaagg      180

ggaggcggag agtgacgcgg tttgcgtctg gagcggctcc ttggagtcca cagcatccac      240

cgccggagcc tcgccttcct ttctccctct gcagacacaa cgagacacaa aaagagaggc      300

aacccctaga ccaccgcgaa ggacccatct gcaccatgac cgagaccacc aagacccacg      360

ttatcttgct cgcctgcggc agcttcaatc ccatcaccaa agggcacatt cagatgtttg      420

aaagagccag ggattatctg cacaaaactg gaaggtttat tgtgattggc gggattgtct      480

cccctgtcca cgactcctat ggaaaacagg gcctcgtgtc aagccggcac cgtctcatca      540

tgtgtcagct ggccgtccag aattctgatt ggatcagggt ggacccttgg gagtgctacc      600

aggacacctg gcagacgacc tgcagcgtgt tggaacacca ccgggacctc atgaagaggg      660

tgactggctg catcctctcc aatgtcaaca caccttccat gacacctgtg atcggacagc      720

cacaaaacga gaccccccag cccatttacc agaacagcaa cgtggccacc aagcccactg      780

cagccaagat cttggggaag gtgggagaaa gcctcagccg gatctgctgt gtccgcccgc      840

cggtggagcg tttcaccttt gtagatgaga atgccaatct gggcacggtg atgcggtatg      900

aagagattga gctacggatc ctgctgctgt gtggtagtga cctgctggag tccttctgca      960

tcccagggct ctggaacgag gcagatatgg aggtgattgt tggtgacttt gggattgtgg     1020

tggtgccccg ggatgcagcc gacacagacc gaatcatgaa tcactcctca atactccgca     1080

aatacaaaaa caacatcatg gtggtgaagg atgacatcaa ccatcccatg tctgttgtca     1140

gctcaaccaa gagcaggctg gccctgcagc atggggacgg ccatgttgtg gattacctgt     1200

cccagccggt catcgactac atcctcaaaa gccagctgta catcaatgcc tccggctagc     1260

agcccctcgt cctccggcaa cacaatggcc cctccatctt tgtcagcccc ctgtttctct     1320

cctgcctctc tgtttctcca tctcctcgtc ttgactgttt tccctacttg ctgacttaac     1380

cccccatagt gtgggggacc tgcagagaac catggcattc cctattccac agtcatcttt     1440

ggacagactt tcctctagtc tccgggttgg gggtgggtga gggaatgggg tgggagtcgg     1500

gggaagtgca gtccttggag atgtactggt gtccgtctcc cagcatgctc tagagaggcg     1560

gctctggtgc ccatcctccc agcacgctct ggggaggcgg ctctggtgcc catcctccca     1620

gcatgctcta gagaggcggc tctggtgccc ctcctcccag catgctctgg ggaggcggct     1680

ctggctcttg ccttcccagc atgcccttta ctacaaaggg ctatttttct tttctttctt     1740

ttgtttattt atttttcttt gttcactccc tgtagaactt ggatgaaatc agtgtccatg     1800

gttctttatg tttgtagtct tgatgtgctc ctgtggtatt acttcccctc tgataggaca     1860

ttgtagccag cctcagcact cagtgagttc atcagggcca cacccagtag agaaggccaa     1920

gcaacctcca cttcttcagc accacacaca cgcacacaca cacacacgca cacatgcgtg     1980

tgcacccgcg cacgcacata cacacacaca tatagcagta gcagcagcag cagcagcagc     2040

agcaaccttt gatcaggagt gagattttcg ggttctgaaa cctgggacac gagtctgtga     2100

atagtcggtt ttctcagaat aatttgaatc tgttttctta gtttcaaatg accatttccc     2160

tgatgctctg agcttatgat cacacagagc cagtccatcc tcatttcctg gtggcatctg     2220

ttcatttacc tttgtggact gtagctgatg gcacagtgcg ggttccctac cagccagggg     2280

tttccaaggg acctttggag gccatgctta gacacattcc tgtacctgag aacaaccaca     2340

taggcaggac cagatccaca tcgtgcagtc gtgtcataaa aaaacaaaac aaaacaaaaa     2400

aacactagga gtccactcaa ccctggaggt ctttgctaat tggaattatg tattgtctgt     2460

tgggctggga aatgtctctt tcatattgta agtccaggat gaactaggag aaagcaattt     2520

gttgccctga tgataactga tgattttcac cctctctagc tgaggtaact cagacagtgc     2580

atgaggtcag tttcttcttg agaagcagtg ccttggtctt gtttctgtgg ttggttctag     2640

cccctgcaga gcctgggagc tgcaggaact gtctgagaaa atctccctaa taggggagtg     2700

ggttcccaga agggagatct gggaggggtc aggagccact aagttgcttc actccttttt     2760

tctctaattt tctaccttcc tctctgttcc tgcagacagt tttgccagct ttgcttctgg     2820

ttactagggt ctcatgcgtg tcctgcttgg agagccataa ggaaattgct gtcttgtgct     2880

ttgtgtctct catccagtct ctggctcttg ggattctggt ctttgagaaa tagtccctga     2940

gtattaggat acttttatca aaatctagta ccagctacgg ccagaaaggg ccaggtggga     3000

cctgaaagca aagacaatgt tctttaccac acgtttcaca tctgcaacat ccttcaattg     3060

cgggaaaagg aacttgattt aacagaagaa catggtagag cagcatccag aaagtctgtt     3120

attcctcttg gattttttga aataatcttc agaggaagga aggaaaatcc tattttgggg     3180

tatcagtgtt tgactaggga tcatgaaata ataaactgaa aaaaacttta gagttcagtt     3240

gatccaacac tttcctttaa aagttgaggg agcagaggcc catgggatta aatggctggt     3300

ccaggtcagc cagcaggtgt agggcctgac aagaacatat tgtttccctg acccctaggc     3360

cgtcacacca caccctccat ttcctcatgt tgctgaccag gtgcccatat gatttctaca     3420

cttcccaagc cttaccctgg catctttctt ttaaattata tctgtcccag gtgctctcca     3480

cacataggat ggtaatgcca gtcccagggg agggtgtgat agtaaggaag gccactgtta     3540

ggtttccttt agaaataaag agatctcagc agcttggaag aaatcccaga agcggactcc     3600

atcaatccaa gaaagagttg ctttgtggaa ggtgaaggaa gacccacaga gtgctcagga     3660

tgatgctatt gctggagagc gaaagatgga acagccttgt ccaggcagaa cagtcataag     3720

ccaggaaatg aaacaaagga aaacaggtgc ctgaatttcc tggggaaaca tggcttgttt     3780

aaggacttgg agttatggat ggaatttatg ggacccacgt gagcagacct gaggaaggct     3840

cgatttcttt tgtttcttgg tccactctgt cactctgctc tggtcaagcc ccatttggtc     3900

tacagcccat gagaaggaat gaggctggtt ctgcactctc agcatgcagt ccgaaagcat     3960

gtgggagtgg ggagggaaag tgagatgaat taagacaaag aacaggtgcc atagaagtag     4020

atttctagga atgaagtggg gcagatctta tctttgtgga ttacaggcac tgtactaaaa     4080

acaggtttcc tatttaatat aaaaagaaag tgaatcttct tttggataga atcatccatt     4140

cccatcgccg caccccctac cccccaaaca cacacacaca cacacacaca cacacacaca     4200

cacacacaca cacacacgcc ctactcttca tttgctaggg gaaggtcaca gcacaactaa     4260

atccaggaca ggacattgtg accatgaccc agccacagtc aataccagaa agatgattca     4320

gagtctgaag tggtgcccca ggtgccaaca ggataacctc taccccccga ctttgtctct     4380

ggggtcctgt tccttcctgc aaagcccaat ccaagactgg catggctcag aggttgtgag     4440

aaaggcatgg actggaacaa tcatgtccag aggggtctgg agctttgttt cctgttcacc     4500

agcaaaaaat gtctctccca tttttctgaa agtggctgat gtaagaacag gcagaaggaa     4560

aacccttttt gtcaataact ctgtccttaa ggaatggtcc tctgggaggg ctgtgctgct     4620

agtgggtacc tcagtcacac acccccaacc ccaggcagcc tctagagcct tcttgctttc     4680

attttccttg aatgtacata ggaacaaggg ggaaagtctc ttactgaagt gcctgaaacc     4740

caaagctaga gcttctagag acgccgttct tcctgtctca gcttggccag cctttcaaca     4800

atgttctcta gtttcaagct ccagcttctc agaaagaatt aaagaacttg ctgttcaaat     4860

taagtagaaa gtgagactca ataataactg aactacagca aaaggcagag aattacaggg     4920

agaaaaaact tgtacttacc agcccaattc tactctcctc aaactgacac acacacacac     4980

acacacacac acacacacac acacacactc ttttagggga ctaagagaga gaagcatgtt     5040

attacatttt actcatccaa acagtaatgc aaaaataaaa cggtagaata tgaaaagctc     5100

aggatctctc ccaaggctac ctactgcagg agggccaaca ggtgagatgg gaagaatgga     5160

aacagggacc gattttgtag ctcatacaat taggacacct taggaatagc attgtagtaa     5220

tggtgatgaa tatgctctgc caaattcatc cagtctgcac catcttatag ctgcccagca     5280

cactcgactg ttcatgtggt ctctttgtag tgtgagtttg gagtgtccta ttagcctgtt     5340

ctggttagga atgagttaac ggctctttcc ctcaacctta gtctagtccc agggctgagg     5400

attcagctgg atccacatgg tcttgagggt tggcatgagg agggggaagc ttttttgaat     5460

cgctttttga tcacataatc tgccatttta agagtaagat ttgctttatg gaaatcaatt     5520

cattaataaa aaatgatatt caagttgcaa taccatttca cagtgaaata ttttgagtac     5580

aattttgttg ctagaatagt catgggcaag agttttatgc aaaatgtttc aattatgtta     5640

ataaataaga caatgctaca aga                                             5663


<210> 594
<211> 4401
<212> DNA
<213> Homo sapiens

<400> 594
tctaccagta cctaagatgg ccgccggccc atccaccgtc gcgatcggtg tgaggaaagt       60

gtcacgaacc cggaattgcc cgactccgtc atggcaggcg ccgggggcgt ggcttccggc      120

ggccacagct tgctagtcgc cgcggcgggg tcgagcgggg gcggcagctg acaggcgctc      180

ctcccccgac cgcagcggct ggttcccagc gaggcgggcg gcccccagct cgcgtccccg      240

agtcctagcc cgcgaggcgc cagggctgcg cctgggcatg gaagagggga agatggacga      300

gaatgaatgg gggtaccacg gagagggcaa taagagcctg gtggtggccc acgcgcagcg      360

ctgcgtcgtg ctgcggtttc tgaagtttcc tccaaatagg aagaagacct cggaagagat      420

atttcaacac ctgcagaaca tagtggactt tgggaaaaat gtcatgaagg agtttttggg      480

ggagaactat gttcattatg gggaggtcgt tcagctacct ttagagtttg tgaaacagct      540

ttgtttaaag atacaatctg aaagaccaga gtctcgctgt gacaaggacc tggatactct      600

cagtggttac gctatgtgcc ttcctaattt aaccagactc caaacctacc gctttgcaga      660

gcaccggccg attctgtgtg tagagattaa gccaaaatgt gggtttattc ctttctcgag      720

tgatgtcacg catgagatga agcataaggt ctgtcgatac tgcatgcacc agcacctcaa      780

ggtagcaact gggaagtgga agcagatcag caaatactgt ccccttgatc tctactcagg      840

aaacaaacag agaatgcact ttgccttgaa gagtttgctg caggaggcac agaacaactt      900

gaagatattt aagaatggtg agctgattta cggctgcaaa gatgcccgga gccccgtggc      960

tgactggagc gagcttgcac accacctgaa gccgttcttc ttcccttcca acggcctggc     1020

cagtgggccc cactgcacaa gggctgtgat cagggagctg gtgcacgtga tcacacgggt     1080

gctgctgagt ggctcggaca agggccgggc aggcaccctg agtccggggc tcgggcctca     1140

gggcccgcga gtctgcgaag ccagcccttt cagtaggagc cttcgctgcc aaggaaaaaa     1200

caccccagag cgctcggggt taccgaaggg ctgtcttctg tacaaaaccc tccaggtgca     1260

gatgttggac ctgctggaca tcgaaggcct ctaccctctg tacaaccggg ttgagcgata     1320

cctggaagag tttcccgagg agagaaaaac cttacaaata gatgggcctt atgatgaagc     1380

attttaccag aagctgcttg acctttccac tgaggatgac gggacagtgg ccttcgcgct     1440

aacgaaggtg cagcagtacc gcgtcgccat gactgccaag gactgctcca tcatgattgc     1500

actgtctccc tgtctgcagg atgccagctc tgatcaaagg cctgtcgtcc cttcatcgag     1560

gtccaggttt gccttttccg tgtctgtgct ggaccttgac ctcaagccct acgagagcat     1620

tccccatcag tataaactgg acggcaagat cgtcaactat tattcaaaga ctgtacgtgc     1680

caaagacaac gccgtgatgt cgactcggtt caaggaaagc gaagattgca cattagttct     1740

ccacaaggtc taactctttc cctgcagtgt ctttgaaact tgaacataat gtgaaggctg     1800

aatgatagag atattttctg ttgtgttggg tgacctttgg ttgtgaatgt ttttgctttt     1860

aacccctttt gaggtgggat tgcctcttgg agacatggaa ttgaagagca ctagaaacaa     1920

cttcctggac aaggaatgta ggaagtgagt gctgtgtccc aggaagctgc tcacactctt     1980

aaaatggaag tgtccgttaa gccctgggaa gacgttctgg atagttcttc tttcccaacc     2040

agggctcatg tctgattctc taatgcgaaa agccttattc taagacccaa ggtttggatc     2100

tgctaccacc agactcctaa catagaaaac ttgaattgtc acatacattt tacagtttgg     2160

acttttaaga aaacatggat actactggaa cttcccccag ctgagttaca tggtcacttt     2220

ttcagtgcaa gccacatatc aacacaggtt tttaggtggt tccctgctgc acagcgtgac     2280

ctcgtggtcg cgcagatgcc gattctgagc agtgtagact cagggtccct gtggaggtgc     2340

tgaagcccac agttccacac agggcagcag ggagcgcaag gctcaggtca ggatggacac     2400

cactcatgcg agcattgacc tttttttttt tgctttacaa tttaatcttt cacatgaggg     2460

ggagatgagc tgttctttcc cactaaaaat tgctgctgta gaagttggag gtggagctgt     2520

gactggctga gctgctgtgg ccgggctggg cagtgtgccc caacagctca gtgctttcct     2580

gacactccag tgtctggggt ggttgaggag cgagttctct cttcctccca gaccaagttc     2640

ctccctcggg tttgccttga gacgtgttgc gtttttgggc cccgtggcct ctccctgtta     2700

ggctgccaca ggccctgctt ctggaaggtg aacagctcct ggctgctgcc gagagggttc     2760

tcgttggggt caccaaagtg tgcccggctg ctatgaaaaa cgttgggaat cttggtttca     2820

gttttttatt ctatgctagg ttgtacagac ttatttatat catcgttttg agggactaat     2880

ggaggcttat tgtaacatat aatattagtg aaaccatgga attatatgaa aatgatacat     2940

gagaaataag gaaactattt tgctgattgt aaatttttgt gggaaatttt gtgataactt     3000

gagaattata cttgtttgaa tcaaggcaac tcttctagaa tttattgttc aattctgtca     3060

tatttacttc taattctact ctcagaggtg caaaaagata cttatctaac tggacacttt     3120

tactgttttc ttctcacttc caatgacacc gtctcataca cacgggtcct gtgtgctggg     3180

atgggggctt tggtgaagtg cacggagctc acggacaagc cgcaggctct gggaagcgtg     3240

gaggtagtgg ccgttgagta ctgtcttgac ccaagggagt tcactgttgc tgggctgggg     3300

ctggggcagc ctggtttggg atgattttgc ccattgtcac ggtgtgtgga ggatgctggg     3360

tcctgggttc aagtgcacat gtgagggaac cccagtccgt gggaaggtgg gctgggctcc     3420

ctaggtcctt cagggctgca agagttattg cctagcacag ggcccagaca gggctggact     3480

agacacgatg aaaacagcct gtatttgagg gagaagagaa aacagatgga gacccccact     3540

ctgtctggtc ttggctccca ccagcccggg ctgtgaggag cccctgagcc gcgggtgcca     3600

ctgctgtgga tgcgtttctg gcccgtcttg gaaactgctg ctgctgcgta gtcatgacgg     3660

ccctgactgg tttgagacaa cacgcgttca cagatcttaa caatgctaaa tgggcgactg     3720

atgaggtcac ggttcttaag gcacatccgg gacgatcgat atagcactta ggctatgcag     3780

gggggtcttt ctttcataaa ggacctcatt ccttgcgtcc cagcccagga acagtgctgt     3840

ctttgctgtc ttaggccatt cttgttatta agctgacagc ttcactttct tgtggaagac     3900

caagaacagc atgaggactt gctgagactg cctcacggtg ccaccatgcg gaccgggggg     3960

aggcagggag tgagggtgtg gctcccctgg gctactaagg acagtttaaa gatgaggcgc     4020

cataggcatc cgtctccaga gcccccagga ggcaggaacc aggataaggg tggcttctcc     4080

cagctgagta atgtggccac catgtccaag gtggactcgg tgtgaggctg cagtgggtgg     4140

gggatggatc ctccccacac atctgaggac acacaaccac ttggtacatt ttctcagatg     4200

ttaagcttat ttttataaac cacattgtac gtgtcacttt tatttggcat tttatactta     4260

actagttgta tttatttttc atgtcatgag agtttccata taatgtgcca taactgcata     4320

gacagcacgt cttcagggtg tggtttctaa gcagaaaata gcaaatgttt atattgaata     4380

aaattgcatg ttcctccacg c                                               4401


<210> 595
<211> 8020
<212> DNA
<213> Homo sapiens

<400> 595
cagtgatgag ttctagaagg aaagaaaagg ctgatgtgac agtgaggaag ggatgagtgg       60

agacttctct gagacttcag tgattcctct tcctctgagc tgagccaagc tgagaagctg      120

agaagagtaa gatagggccg ggaactcagg tccgttagtc cgtcctccga ggtggggcgg      180

gccagcagaa tggatttccg atctactctg tgagagcctc gcccaagaaa gcccagagcc      240

acttccaaga tccgcgctcc cacggcgatg agaagcgttt tcccccggga ctgcttggct      300

taggactggg gacccactgg ctttggagta agccctggca cgggcctcga gggaagaaag      360

aactcccgcg ctccccacac tccacagggc ctgcgatcat ctcagatgtt ccggttccac      420

gtgcagaaac cccgccggtc cgaggccccg gttctaaaac ggccctaaga gtcaaggctt      480

ccacagctcg cctctgaggg tggcaaagag gccgcggggg cggtgcctcg cgagacccaa      540

acaagcccac gtggcagggg cggggctccg cgaaggcgtc acggcgcgct cgtgcgctgc      600

tgaggtcacg cgccggcagt acccttgccc gggggccgta aagcgcggaa ggtcgcggtc      660

tcggcttccc cggaactttt tgctcgcttc gccccgcccc cttcccatcc ccgaaccccg      720

ctttccggcc cgcggcgacc ccaggcaact gttgtggctg ccgcattgct cccgccgggc      780

tgtagctgag cgcggagccc gtggggaccg gtgagatgga actgttttcc cgcgttgaga      840

cgtgcggtcc gcttgtgctt ttagaactaa agactgctgc agagtccgga ggaagaagtc      900

acctagaaaa atctgggaca gggcatttga gttcctgaga tctagttggt gagagacatg      960

atgttctacc ggttgctgtc gattgttgga agacaaagag ccagcccagg atggcagaac     1020

tggtcctctg caagaaacag cacgtcagct gccgaggcgc gttccatggc cctgcccacc     1080

caggcacagg tggtcatctg tggaggtgga atcacgggca cttctgtggc ctatcacctc     1140

tccaaaatgg ggtggaagga tattgtcctt ttggagcagg gcaggctggc tgctggctct     1200

accaggttct gtgctggcat cctgagcact gccaggcact tgaccattga gcagaagatg     1260

gcagactact caaacaaact ctactatcag ttagagcaag aaacagggat ccaaacaggt     1320

tacacaagga caggctcaat ctttctggcc caaactcagg accgactgat ctccctgaag     1380

cgcatcaacg cagggctgaa tgttataggt atcccttctg agatcatctc ccccaagaaa     1440

gtggccgagc ttcaccatct cctcaacgtg cacgacctgg tgggggccat gcatgttccc     1500

gaggatgcag tggtgtcttc cgctgacgtg gctcttgccc tggcaagtgc tgcctcccaa     1560

aatggtgttc agatctatga ccggacatct gttcttcatg taatggtcaa aaaaggtcaa     1620

gttactggag tggagaccga taaaggacag attgaatgcc agtattttgt caactgtgct     1680

ggccagtggg catacgagct gggtctgtcc aacgaggagc cggttagtat cccgctacat     1740

gcctgcgaac acttctacct cctgactcgc cccttggaga cccctctgca gagcagcaca     1800

ccaactattg tggatgctga tggaagaatt tatattcgga actggcaggg tggcatcctg     1860

tctgggggct ttgagaagaa cccgaaacca attttcactg agggcaagaa ccagctggag     1920

attcagaatc tacaggaaga ctgggatcac tttgagcctc tgttgagttc ccttctgagg     1980

aggatgccag aattagagac tctggagatc atgaagttgg tgaactgccc agagaccttc     2040

acaccagaca tgaggtgcat catgggcgag tctcctgcag tgcagggcta ctttgtcctg     2100

gcaggaatga actctgctgg cctttcattt ggtggaggag ccggaaagta ccttgccgaa     2160

tggatggtac atggttatcc ctcagaaaac gtttgggaat tggacctgaa acgttttgga     2220

gccctccaga gcagccgcac ctttctgcgc caccgggtca tggaagtcat gcctttgatg     2280

tatgatctga aggttccccg ctgggacttc cagaccggta ggcagttacg cacctctcct     2340

ctctacgacc ggctggatgc acagggagcc aggtggatgg agaaacatgg atttgagagg     2400

ccaaagtact ttgttccccc cgacaaggac ctcctggcat tggagcagag caagactttc     2460

tataagccag attggtttga catcgtggag tctgaagtca agtgctgtaa ggaagctgtg     2520

tgtgtcattg acatgtcctc tttcacaaag tttgagataa catccactgg ggatcaggca     2580

ttagaagttc tacagtacct cttctccaat gacctggatg tgcctgtggg ccacattgtg     2640

catactggca tgctcaacga gggtggaggg tatgaaaatg actgcagcat agcacgactg     2700

aacaagcgca gtttcttcat gatctctcca accgaccagc aggtccactg ttgggcctgg     2760

cttaagaaac acatgccgaa agacagcaac ctgctcctgg aggacgtcac ctggaagtac     2820

acagccctca atctgattgg ccctcgagct gtggatgtgc tgtctgagtt gtcctatgcc     2880

cctatgactc cagaccactt cccaagcctc ttttgcaagg agatgagtgt gggctatgca     2940

aatgggatcc gggtgatgag catgacgcac acaggagagc caggattcat gctctacatc     3000

cccatagagt acgccctgca tgtatacaat gaagtgatga gtgttggcca gaaatacgga     3060

atccggaatg ctgggtatta cgctcttcgc agtctccgaa ttgagaagtt ttttgccttc     3120

tggggtcagg atataaataa cctcaccacg cccctggaat gtggacgaga gtctcgggtg     3180

aaattagaga agggcatgga tttcattggt cgcgacgccc tcctgcagca gaagcagaat     3240

ggagtgtata aacgcctcac catgttcatc ctggacgacc atgattcaga cctagacctt     3300

tggccttggt ggggagagcc catttaccgg aatgggcagt atgttggcaa gaccaccagc     3360

agtgcctaca gctacagcct ggagcgccac gtttgcctgg gctttgtgca caatttttct     3420

gaggacacgg gggaagagca agtggtgaca gcagatttca tcaaccgggg agagtatgag     3480

attgacatcg cgggataccg cttccaggcc aaggccaagc tctaccctgt cgcctccctc     3540

ttcacccaga agcgccgaaa ggatgacatg gagctgagtg acttacatgg gaagtgatgc     3600

caccagggca gcctcacctc ctccccatca tcttgtccta gagtgggcgt caccttggag     3660

cttctcttcc ttccgcctct gttcctcttc tggagccttt gcctcccatc tcttatctcc     3720

ttgatataat tttgaacttg acctacttta aacttttttg ctctgcagcc ttccttgccc     3780

ttccacctcc tcctcctaat attcactctg ggctcttctt cccttcccac ccctcactca     3840

gcttctcgtg gtggcaggag gtatgtctga caggacagaa gcaagctcca ctgtggacat     3900

gagtgatggt gacagctgct ttcaaattct gcatctcaag gcagggcaag ccggggtggt     3960

gcaggtctca gggcacgagt ccctctccct tgggttccat tttcttggag cagcctatta     4020

gttctggtgg ggttgccgtg tgtcggatgc agccctgagg ggcagctcgt gcctgcagcc     4080

cggcagctcg ttctcctgtt ctgctgtgct gtgggctggc actcgatacc tctggcaaga     4140

ggatgattat ctacctcact gataagaggc atcgcatgga cgttctctgg tctgtagtgg     4200

agacaagcag ttaacctagc accatcctca tcctccctgc agaagccatt agcagacctt     4260

tgggccaggg cagcctccct ataattttct tcatctcttg ctaatctcta taataaggtt     4320

gctttttctt tcttagttga gtaaacaagt aagccacagt gtttgaaagg gaaaaaccat     4380

attgccttgt gtgttgcttt tcccagtcaa aagggtctga ccttagaaag tccccaccag     4440

tgatgctgag tgttctgcta tggaaacaat gctgcttttc tctcagctgt ccaaagttca     4500

gccgttcctc cttccccttc tcccagtgcg tttgactttg tcaggtcagc ctcacttgtc     4560

cctttcacag ttggcccata aagtcatgtt tctctccctt tagaataggg aggggaaggg     4620

atcaggtgtg ttgtcctggg cctttcaacc ttgcgggctg tgctgagttc cagagagctg     4680

ccggaattcc aggtttgact ctccagcaca gagcagagct acacagaggt gacccacgtt     4740

agtccactga gagttctgag tccaaagggt gtacgttgca taaggctaga gaccgctttt     4800

cctcctttcc ccccaggctc tttgtttccc tccacccacc cttccatatc ctctggagca     4860

ggagacaatg tgggtgccca gaagtgccct gcgctttcag gcagtgtctc tgttttccca     4920

aggtgaaact tagatatcat ggactgttgt ccagcctcaa tgcttcattt tccccttgca     4980

tatcaactgc cctaatctga ctttttttaa gtgcaaataa actgctataa gacattttgg     5040

ttagtaaaac tctagccttt ggcgtgttgg tatcttggaa gcattagctc tgataggtct     5100

ataagtgtat taagggacat ccttccattt cattagagca gcttaaaatg ctcaggtgtc     5160

tgccttctct ggtgtttctt tgggatctct gtttacccac ttacgctggc tccttctaga     5220

catttcttgc cacttcccca actagaccac tcctagtgat tactgacttt agtgcctaaa     5280

cctttttgga aggttctggt tggcttgtta gaggagcata tgattagaat tctgtttggg     5340

ggtctagttg tcttggagca agtatgtact taactagccg agagatgctg cctctaggca     5400

gagaggagga gaggtgttgc cggctggagg gccaaccagt gaacaccagc tgtgaaggcc     5460

ttgggagagg aggaacaggc ccttgggcag atgcaggcat taccagcagg gagcagactt     5520

acctccgaag atggagacag gtgactgaga gctgcaggcc tcctctgctc ttccaaacac     5580

gtagcatttg cacccctcca aagccatctt tgtaaaggaa aacgtatttg taattgaatc     5640

cagaagaatt tagttacaca tagacataac tcttcaacct taactatggc aatacatttg     5700

tgctttaact gttacatagc agtatcacca cttaccagga tccaaatcga aataataaaa     5760

gctgtctcca tagtttaaaa tcgaatagtg ccatcatcac agtatattag tcaaatagaa     5820

gcttcatcag aaatgtatcc cacatagagt tttaagactt ggattctctt ctgcccttgt     5880

taatctccaa ctaattacta cagattgaca cgtttttaat tagctgtcct ttgtaagaag     5940

tcaggaaatc tgatgctgtg tccaaaatta tgcactgttt gttgaagtag aaccagaaat     6000

cctgacctcc tgttaaatga catcagtttc cccctctgag caacagactg cttgtcttgc     6060

taggagagga ggatgggggg ctgagcactc aggctgtcca ttgaaacccc ttgtccatga     6120

atagggtcat actcctaaga ctgatggggt gttgatcttc taggacatca cttgtttatt     6180

cagtgcccca aacacagatt tctcttctag cactttagag ttgatccttg aagtctctcc     6240

tggttcattc aaatacaagc tgtgtgagtc tggtggtttt ctgtgattgg tctaatgtga     6300

gctctttgaa cagacagatc tgacagtgaa tgactctccc ctgcttctgg cataactgct     6360

ttgcctctgt ctagtgtcca agcatcttag ctgttcaaga ggagagggca gcataacttc     6420

ctgaccaccg gtgtcagata tcagagcatt ctggactcct gagaggcagt ggcctcttga     6480

gtgaacaggg gaggccagta gatgccccag atccagagcc gtggctgcaa atccagcagg     6540

aataaggagg gacaaccaca gcctcctcat ccatgtgtca tttccaaggg tttgccttgt     6600

gtctcagctc attctgggca gcacgtttgt cttctgtccc tagagatttg aaggattttg     6660

gactcttgtg aatgggtgac tggacttggc tttacagagt tgggtgcttt tttctctctg     6720

caattacctg tcatagcatt ttgtgctcac cacgaaggat ggtctctgcc ttctcttgtc     6780

ggtgtatgcc atctgaacct aggaacacaa agtatattgg cctcaaacgg agacccaggg     6840

ttgccagttt tccgtgggcc ttcccctccc ttgaaatgtc tttaattacc tccccttcat     6900

cgtcaggcca cgtgtgactt ctgttcttag cactgccagg gtcattgact tccatctaag     6960

cttgcatcag gaagatgttc cttctgtgat cattggtact gaagccagaa aagctctcat     7020

tcaggaactc tgaagagcaa aaagggacaa acactaactg ctgagctggg ccatttgatc     7080

tcctttcacc ttgcattgct gtcacagcac cttgtatgat ggcaggacag gctccagcag     7140

agagaactgc acagtgacca ctgtattttt cacgctcttc cagggatccc tgtcccccga     7200

cattgaagag atctcattca ggccagagac acagagacca catagcccag tgattaaacc     7260

ccggtttcac tctggcccca ggagtggagc ctggccactc ctgtttggtt ctcactggga     7320

ggcccactgg ccttggatca tctcctcatg cacacccgga gttttacctg cttgcttgct     7380

ttcctggact gctgtttgca agaaagtaac taaaacatga aaagtaaacc tccagcttcc     7440

acagtatatt acctgccgtt gcatgcattt gaaagttagc ctcctccctt gccaccgtct     7500

tggtggcagt agcgatgcaa gaatgatggg agctttccga gagcgttcag tgtttcactg     7560

aagacaggac ccatagcctt catttctggc tctgtgtctc ctctggcata tggacacatt     7620

tcctggcatt tgcctgagtc tacaccactt tttgagaacc tgaaatagaa gggaatcttc     7680

tgtggcccac agtctccata ttggcactag aagactggcc tggcggagga atttgcgttg     7740

gcttgctttc aggggttagc tacaagattc agctttatat ctctgttgct tcttggccag     7800

tgtagtcaat aagggtcttc tttaacatct aagatagagg tttggttggc cgggcgtggt     7860

cgcttactcc tgtaatccca gcactttggg aggcccagtg aggtgggaga attgcttgaa     7920

cccaggaggc agaggttgca gtgagctgag attgcaccac tgcactccag cctgggtaac     7980

agagtgagac tcttgtctca aaaaaaaaaa aaaaaaaatc                           8020


<210> 596
<211> 3260
<212> DNA
<213> Homo sapiens

<400> 596
ccggtctgca gccttgtagt ggggctggag cagagcctgc cgcgaacccc cggagcccac       60

gatccctcgt gccatccctc gaatccacca gcacgagcgt cccacccgcg cctgggacca      120

tggccactga ctcatgggcc ctggcggtgg acgagcagga agctgcggct gagtcgttga      180

gcaacttgca tcttaaggaa gagaaaatca aaccagatac caatggtgct gttgtcaaga      240

ccaatgccaa tgcagagaag acagatgaag aagagaaaga ggacagagct gcccagtcct      300

tactcaacaa gctgatcaga agcaaccttg ttgataacac aaaccaagtg gaagtcctgc      360

agcgggatcc aaactcccct ctgtactcgg tgaagtcttt tgaagagctt cggctgaaac      420

cacagcttct ccaaggagtc tatgccatgg gtttcaatcg tccatccaag atacaagaga      480

acgcattgcc actgatgctt gctgagcccc cacagaactt aattgcccaa tctcagtctg      540

gtactggtaa aacagctgcc ttcgtgctgg ccatgcttag ccaagtagaa cctgcaaaca      600

aataccccca gtgtctatgt ctctccccaa cgtatgagct cgccctccaa acaggaaaag      660

tgattgaaca aatgggcaaa ttttaccctg aactgaagct agcttatgct gttcgaggca      720

ataaattgga aagaggccag aagatcagtg agcagattgt cattggcacc cctgggactg      780

tgctggactg gtgctccaag ctcaagttca ttgatcccaa gaaaatcaag gtgtttgttc      840

tggatgaggc tgatgtcatg atagccactc agggccacca agatcagagc atccgcatcc      900

agaggatgct gcccaggaac tgccagatgc tgcttttctc cgccaccttt gaagactctg      960

tgtggaagtt tgcccagaaa gtggtcccag acccaaacgt tatcaaactg aagcgtgagg     1020

aagagaccct ggacaccatc aagcagtact atgtcctgtg cagcagcaga gacgagaagt     1080

tccaggcctt gtgtaacctc tacggggcca tcaccattgc tcaagccatg atcttctgcc     1140

atactcgcaa aacagctagt tggctggcag cagagctctc aaaagaaggc caccaggtgg     1200

ctctgctgag tggggagatg atggtggaac agagggctgc agtgattgag cgcttccgag     1260

agggcaaaga gaaggttttg gtgaccacca acgtgtgtgc ccgcggcatt gatgttgaac     1320

aagtgtctgt cgtcatcaac tttgatcttc ccgtggacaa ggacgggaat cctgacaatg     1380

agacctacct gcaccggatc gggcgcacgg gccgctttgg caagaggggc ctggcagtga     1440

acatggtgga cagcaagcac agcatgaaca tcctgaacag aatccaggag cattttaata     1500

agaagataga aagattggac acagatgatt tggacgagat tgagaaaata gccaactgag     1560

aagctccacc agccactgat gccagccctg gcactgcccc tgcacaggag acaagtgcgt     1620

tcagggcaca ggccccgaca tcaccccaag gacaacggca caagtagaga gaaactacct     1680

acctcacttc aaattatgtt tggacttgac aaaaatgtat gcaaatgatg ggggatggta     1740

gaaaaaaatt atttacacaa ccttggaaga ttaggcatga atacacagag atttaccttt     1800

tggaagtttc atcttttaat ttggccagtg tttccttcat gctaatctag atgctgtggc     1860

tgattacttg cccaggatct cctgtggcag cctctgcttg ttctctggct tggagtggat     1920

ggggcagcct ccagctcctg tggaagtaat ggaatagtgg tggaaaggga acacagagag     1980

ggaggcttcc agtaagatag gtgtgtaagc ccagccatca tgtttggaat ggcatgaggc     2040

agcagaggag gcctgagagc tgctgctttg gacttggggg tgggacagct catctgagta     2100

ttgccagccc cctgtcctag tgcccacagc agaagggaat ttgttaaata agcatggacc     2160

aaaatgccaa cctctcggtt gtgtatatgg gtttgtgtca caggactgtg acctgttctc     2220

ggtgggtgca gtctgtgtag agtgcacatc tgattattgg tgggtcctgt gcctgtgctt     2280

aagcaagtcc tgtggagaag tcatcatgga gaattagtgg tggccctagc gtgccacaaa     2340

acctggtctc atgagcattt gcaacatccc ttttacatcc ttaatatccc cttaccccac     2400

agtagcccca aacaaatgtg atctgaggtt tagatcctca gtgaaaattg tggtttcaag     2460

tcttcatggc cagcctcaag gcagttctag atgtgatcag cagtagtcac aaattcttgt     2520

tttgtctcca cacccagaag gcaagttttg tcagagctgg ggaataattt cagatatttg     2580

acatcttgat tataaagggc ttctgaacat ctgtgtttac tgcctttgga atacaaacag     2640

gtgcaactga gggactagct acactaccac catttatctg tccaaggcaa gagtatcacc     2700

aaggcctttg ctccagcctt acttggcatc tttgcgcaag atagtcagag caaacaatag     2760

taatggacac ttctcacacc tggccaaggc tgttggtacc cacgaaatga cagcaaagat     2820

gagaggaaac tgaattgcaa gagcaatatg aaaccccaac caagaggagt actctgcagt     2880

tctttggctt tggtatagag tggccacttt ctctaggacc tggaagaaga gtttgatggc     2940

taagaacgat tgtgatccta ggtcttcttt gtacgcatct ccgtatttag gccagatctg     3000

cctcctggga agggaagggg ccaatgtcag cctccaggtg atttctttaa tctgacatta     3060

caaagagacc aacagactgc caattctacc acattcccct ggtgggtact cgactatgta     3120

gttttctcta tgcttctggt caactctgac acatcttgga attcttgtaa taagaaaaga     3180

aatttttata cttttttctc cttccctgag tcctgtggac caaccctgaa atactaaaaa     3240

caagggcaat aattaaagaa                                                 3260


<210> 597
<211> 3907
<212> DNA
<213> Homo sapiens

<400> 597
aaagagcccg ctccgccgag cgccgggcga cggcaggaag cccctccgct tggccagaat       60

ggagcagccg aagggagttg attggacagt catcatcctg acctgccagt acaaggacag      120

tgtccaggtc tttcagagag aactggaagt gcggcagaag cgggagcaga tccctgctgg      180

gacgctgtta ctggccgtgg aggacccaga gaagcgtgtg ggcagcggag gagccaccct      240

caacgccctg ctggtggctg ctgaacacct gagtgcccgg gcaggcttca ctgtggtcac      300

atccgatgtc ctgcactcgg cctggatcct cattctgcac atgggtcgag acttcccctt      360

tgatgactgt ggcagggctt tcacctgcct ccccgtggag aaccccgagg cccccgtgga      420

agccttggtc tgcaacctgg actgcctgct ggacatcatg acctatcggc tgggcccggg      480

ctccccgcca ggcgtgtggg tctgcagcac cgacatgctg ctgtctgttc ctgcaaatcc      540

tggtatcagc tgggacagct tccggggagc cagagtgatc gccctcccag ggagcccggc      600

ctacgctcag aatcatggcg tctacctaac tgacccccag ggccttgttt tggacattta      660

ctaccagggc actgaggcag agattcagcg gtgtgtcagg cctgatgggc gggtgccact      720

ggtctctggg gttgtcttct tctctgtgga gactgccgag cgcctcctag ccacccacgt      780

gagcccgccc ctggatgcct gcacctacct aggcttggac tccggagccc ggcctgtcca      840

gctgtctctg ttttttgaca ttctccactg catggctgag aacgtgacca gggaggactt      900

cctggtgggg aggcccccag agttggggca aggcgatgca gatgtagcgg gttatctgca      960

gagcgcccgg gcccagctgt ggagggagct tcgcgatcag ccccttacca tggcctatgt     1020

ctccagcggc agctacagct acatgacctc ctcagccagt gagttcctgc tcagcctcac     1080

actccccggg gctcctgggg cccagattgt gcactcccag gtggaggagc agcagcttct     1140

ggcggccggg agctctgtgg tcagctgcct gctggagggc cctgtccagc tgggtcctgg     1200

gagcgtcctg cagcactgcc acctgcaggg ccccattcac ataggcgctg gctgcttggt     1260

gactggcctg gatacagccc actccaaggc cctgcatggc cgggagctgc gtgaccttgt     1320

cctgcaggga caccacacgc ggctacacgg ctccccgggc cacgccttca ccctcgttgg     1380

ccgtctggac agctgggaga gacagggggc aggcacatat ctcaacgtgc cctggagtga     1440

attcttcaag aggacaggtg ttcgagcctg ggacctgtgg gaccctgaga cgctgcccgc     1500

agagtactgc cttcccagcg cccgcctctt tcctgtgctc cacccctcga gggagctggg     1560

accccaggac ctgctgtgga tgctggacca ccaggaggat gggggcgagg ccctgcgagc     1620

ctggcgggcc tcctggcgcc tgtcctggga gcagctgcag ccgtgcctgg atcgggctgc     1680

cacgctggcc tctcgccggg acctgttctt ccgccaggcc ctgcataagg cgcggcacgt     1740

gctggaggcc cggcaggacc tcagcctgcg cccgctgatc tgggctgctg tccgcgaggg     1800

ctgccccggg cccctgctgg ccacgctgga ccaggttgca gctggggcag gagaccctgg     1860

tgtggcggca cgggcactgg cctgtgtggc ggacgtcctg ggctgcatgg cagagggccg     1920

tgggggcttg cggagcgggc cagctgccaa ccctgagtgg atgcggccct tctcatacct     1980

ggagtgtgga gacctggcag cgggcgtgga ggcgcttgcc caggagaggg acaagtggct     2040

aagcaggcca gccttgctgg tgcgagcggc ccgccactat gagggggctg gtcagatcct     2100

gatccgccag gctgtgatgt cagcccagca ctttgtctcc acagagcagg tggaactgcc     2160

gggacctggg cagtgggtgg tggctgagtg cccggcccgt gtggatttct ctgggggctg     2220

gagtgacacg ccaccccttg cctatgagct tggcggggct gtgctgggcc tggctgtgcg     2280

agtggacggc cgccggccca tcggagccag ggcacgccgc atcccggagc ctgagctgtg     2340

gctggcggtg gggcctcggc aggatgagat gactgtgaag atagtgtgcc ggtgcctggc     2400

tgacctgcgg gactactgcc agcctcatgc cccaggggcc ctgctgaagg cggccttcat     2460

ctgtgcaggg atcgtgcatg tccactcgga actccagctg agtgagcagc tgctccgcac     2520

cttcgggggc ggctttgagc tgcacacctg gtctgagctg ccccacggct ctggcctggg     2580

caccagcagc atcctggcag gcactgccct ggctgccttg cagcgagccg caggccgggt     2640

ggtgggcacg gaagccctga tccacgcagt gctgcacctg gagcaggtgc tcaccactgg     2700

aggtggctgg caggaccaag taggtggcct aatgcctggc atcaaggtgg ggcgctcccg     2760

ggctcagctg ccactgaagg tggaggtaga agaggtcacg gtgcctgagg gctttgtcca     2820

gaagctcaat gaccacctgc tcttggtgta cactggcaag acccgcctgg ctcggaacct     2880

gctgcaggat gtgctgagga gctggtatgc ccgacttcct gctgtggtgc agaatgccca     2940

cagcctggta cggcaaactg aggagtgtgc tgaaggcttc cgccaaggaa gcctgcctct     3000

gctgggccag tgcctgacct cgtactggga gcagaagaag ctcatggctc caggctgtga     3060

gcccctgact gtgcggcgta tgatggatgt cctggccccc cacgtgcatg gccagagcct     3120

ggctggggca ggcggtggag gctttctcta tctgttgacc aaggagccac agcaaaagga     3180

ggccttggag gcggtgctgg ccaagaccga gggccttggg aattacagca tccacctggt     3240

tgaagtggac actcagggcc tgagcctgaa gctgctgggg accgaggcct caacctgttg     3300

ccctttccca tgaagctggc ttctctctgc aacaggagaa aacctggagc tacagtgtcc     3360

cccaccttcc ttgccccatg ggaacctcca cctcctactc cccacccacc tctgcgaatc     3420

tgctcccaaa ggaagctgac cagagcaaga tctgggcaag cagagagtgc ctgggacagg     3480

actgtgacct ggtggacagg ggcctagatg tagcctctgt tcctcctgga cataggaagg     3540

tcccaagctt agtatcccac gtggccttta caaatcctat ggctggcctt ctcattccac     3600

aagggccctg gaaagggttg acagccagcc ttggcatatg gctgggagtc ccttagcaag     3660

gccaaccctg aagaggccct ttgaggcatt ccctatggct tagagttgta gacttacact     3720

caaccctcat gtgagcgtgg gagtgagggt ggcggtccct tgccaagttg gtagcagtga     3780

cccagtgatt cactgccatc ccaggcctta actagcaaaa ctacggagcg tgccaagtga     3840

cctggtgcct gtgggaagtg ggttctcagg actggcattc ttggaataaa ttcactctgt     3900

ccttgca                                                               3907


<210> 598
<211> 4564
<212> DNA
<213> Homo sapiens

<400> 598
aagatttggg ggtcgccttg ccggcctcct gtcctcctcc ggcggcggcg gagcccgaga       60

gaactaggtg aacaccgctt tgccagcctc acacagcgtc ccctggctct gccgccgctc      120

cggacgtcgc cctcccgttc tgcttgggtc cccttagtcg ctacctttgc tgggatcccc      180

ctcctccatc ctgtggcttc gggttgccga agagcgatgc tcggagggcg gccggaagtg      240

gcgttggccg ccattggcct gccggccagc caccttgctg tcctccgccg ccttccgggt      300

gttacatgca gccgggctcg gcccctcccc ctggccggat ggatccgtcg gcgccacagc      360

cccgcgcgga aacctcaggc aaagacatat ggcatccagg agaaagatgt cttgcccctt      420

ctccagataa tggaaaactt tgtgaagcaa gcataaaatc tatcacagtg gatgaaaatg      480

gcaagtcatt tgcagtcgtc ttatatgcag attttcaaga aaggaaaata cctcttaaac      540

agcttcaaga agtgaaattt gttaaagatt gccctaggaa tcttatattt gatgatgaag      600

atttagaaaa accttatttc ccaaaccgaa aatttccatc atcttctgtt gcttttaaat      660

tatctgacaa tggagactct attccttata ccatcaatag gtatttgaga gactaccaaa      720

gagaaggaac ccggtttctt tatggacact acatccatgg aggagggtgc attctgggtg      780

atgacatggg acttggaaaa acagtacagg ttatttcatt tctggctgca gttttgcata      840

aaaagggaac tcgtgaggat attgaaaata acatgccaga gtttttacta agaagtatga      900

aaaaggaacc cctttcttct acagcaaaaa agatgttctt aatagttgct cctctttctg      960

tcctctacaa ctggaaggat gaattggaca cctggggata tttcagagtc actgttttac     1020

atggaaacag aaaagataat gaattaattc gtgtaaagca gaggaaatgt gaaattgctc     1080

taacaactta tgaaacacta cgcttatgcc tggatgaact taacagtttg gaatggtcag     1140

ctgtcattgt ggatgaagct catagaatca agaatccaaa agctagagta acagaagtta     1200

tgaaagcttt gaaatgtaat gtccgcattg gcctcactgg aaccatcctt cagaacaaca     1260

tgaaggaact gtggtgtgtt atggactggg ctgtgccagg ccttttaggg agtgggacct     1320

acttcaagaa gcagttttct gacccagtag aacatggtca gagacacacg gcaacaaaga     1380

gagaactagc cactggccga aaggccatgc aaagacttgc caaaaagatg tctggctggt     1440

ttctcaggcg caccaagact cttatcaagg atcagttgcc taagaaggaa gaccggatgg     1500

tgtattgttc tttgacagat ttccagaaag ctgtctatca aacagtgtta gaaacagagg     1560

acgtgacttt gatacttcaa tcttctgagc cttgtacctg taggagtggc caaaaaagga     1620

gaaattgttg ttataagacc aattctcatg gtgaaacagt gaaaaccttg tatctcagtt     1680

accttacagt ccttcagaag gtagctaacc atgtcgcgct actgcaagct gctagtactt     1740

ccaaacaaca ggaaacactt atcaaaagga tatgtgatca ggtattttcc agattcccag     1800

attttgtgca gaaaagcaaa gatgcagcct ttgaaacact ttctgaccct aaatacagtg     1860

gaaaaatgaa ggtccttcag cagcttttaa atcattgcag gaaaaacaga gataaagttc     1920

ttctcttttc tttttccacc aagttgcttg acgtgctaca gcagtactgt atggcgtctg     1980

ggcttgatta ccgacgactt gatggaagta caaaatcaga ggaaagactc aagattgtaa     2040

aagagttcaa cagtacacaa gatgttaaca tttgccttgt ctctacaatg gctggtggac     2100

taggcctcaa ttttgtcggt gccaatgttg ttgtattatt tgatcctact tggaatccag     2160

ccaatgatct tcaagccatt gacagagcat ataggattgg acaatgtaga gatgtcaaag     2220

tgcttaggct gatatccttg ggaactgtgg aggaaatcat gtatttacga cagatataca     2280

agcagcaact tcactgtgtg gtggttggaa gtgaaaatgc caaacgatat tttgaagcag     2340

ttcaaggatc taaagagcat caaggagagc tttttgggat ccataacctc ttcaaattta     2400

ggtcccaagg gtcttgtctt acgaaggaca tcctggaggt gtgaacttct tctctgacct     2460

tttcaataat attttaaata cagtttttct tcctcaggaa atctgaaata caattgctgt     2520

tgccttttca gagaaacttt tggttttctt tatcaaaaat gccttggaat ttttactttt     2580

agagaataag aaatgaatta ttgtacctct aaactaagat tttcccatgc ataattacaa     2640

ataatgcaca cacacaaatg tatatgctgg gtagtatgaa ctccaaggca attttaaata     2700

ggcagagaga agtttatagt tttgaaaaca gctgctgaag tcaggaacta aaaaaagagg     2760

ttttcctaaa taaacaaaaa tataaaatgt gttttaatta aaagttacca aatactccct     2820

gagatgtact ctcatgtctc atggagattt ttgttttctg ttcccaataa aaattccaca     2880

ccagtatttt aaactctccc tgttgtgttc atcctcagca tacagatgtt tcttattcct     2940

caaacaaaat attttatatc cttttttaaa aaaatcttta agttctttta tataccggaa     3000

tactaaggat attaacctat tttctaattg atattcatat aggtatcata aaatcctgga     3060

gtatcatctt tttcaacctc ctcatggtat agatgaggaa actgagtctt agagaacttc     3120

aggatatttc tcttgacttc caggactttg tagtaaaatc ttaatgtact tcatttattc     3180

agtaagtacc ataaaggcag ttcaaggagc aattggttcc tgtccttgag gaacttaaac     3240

catcttgacc ggaggtggaa gagaacgttt acataataac catgcaatgt caggaatcgt     3300

atgctgaaca agttaaacag tagaccatgg atggctgggg gagaggaagg tatatattat     3360

ttgaatccta taaatgttgt tactattata cagtttctga tatatactgc tgagtttcta     3420

ttttatagta actatatttg attctgaatt cagtggccca tttggagtcc tactttttgg     3480

ggttttttcc ccttgctttt taaatacgct gtttctttca tgaatttgtt ctttccagtt     3540

tcccttttca tatcaataac tttgtttgcc ctccagctcc caaacccagc tgctacctcc     3600

atctcagagt actacttgac atgcctatat tgatgttaaa gtcaattgtc tataaaaata     3660

ttagcatttt attatttatc ctgttttctg tcatatatga catagttacc tgtttttatc     3720

agaataacca cctatttctt tgttaaacaa gtgttatata agacatatca ggatgacagg     3780

ttattaagta gaaaaagttc ccttgtttat cgtgccactg cactccagcc tggggaacaa     3840

agcaagagac ttgtctcaaa aacaaaaaac aaaaacaaaa aaaagttctc ttgttcactg     3900

gttattctaa gaatatcttg tttcaccttc agaagtgttt attaatgaca ggaccatcca     3960

tgtcttacat tttctttttt aaaaatatct tttaagttct ttaatatacc agaacactaa     4020

gaatattaac ctattttcta attgatatta ataaggggtg acaaggccat ccatgcccta     4080

catttgtctt gctaggcata tcattggcac ttgattatta agttaaattt tgaattaaaa     4140

ttactcattt gtcatcaatc agaatgtaaa tttattcagg attggttaga ttcatgctgc     4200

tttgggccaa aaggtgcttc taaatattat tattagcccc atataatggg agtacctatc     4260

ataaagtaaa aggagtattt cacttcatgt gagacatttt taatttttaa aggttgtata     4320

aaatctcttt taaaatgttt taagatgtaa aaatttgaat atttacactt ataatcttat     4380

gatttctggg caatttcatt ctgttttgca ttgactttcc attatctata ttatggtttc     4440

tcttcaaaga tagatattga gagttcattt tacaagtatt tgttgagcat ctgctaaatg     4500

tcaggtactg ttcatagagc tttgcataca taaaagaaca aaataaacaa aacgatcctg     4560

tcta                                                                  4564


<210> 599
<211> 2586
<212> DNA
<213> Homo sapiens

<400> 599
gttttccgga gactgttaga ggaagagtcg ctttttcctg cctcccaggc tgcccagcgg       60

cgccggttgc cggggaacgc aggcgccgtg gggagggatg gcgggaggat actgcttagg      120

tgctggagac ggagttgagc tggtgaagaa gagctcgggc tcatcatgaa acaacgaaaa      180

ggccaagggt ctgggggcag ccgtgggcgc aaaaaaagag gtttaagtga catttctcca      240

tctacaagcc tgccacctct ggttgaaggc cagctacgct gttttctaaa acttactgtt      300

aatagagtca tatggaagat tgcaaagcct cccacttgtg tacttgtccg agtgagatgg      360

tggggagaaa catcagatgg aaccctcttt tgtcccaggg atgcattgca gactgaacca      420

aaagctgtga gaacaactac acgttacgct attcgttgtg gtccaaaaca gtttacctct      480

tatctaacag atatggctgt gctggtgctg gaagtaatca ccaaacttga tggtcttcca      540

attggtagag ttcagatcaa tggactagct caactttctc caacccatca aatcaatgga      600

ttttttacca ttgtttcatc aacgtctaag aaacttggag aactccaggt ctcacttgcc      660

ctggaacctc tgtcagaaac ttacgacagc taccatccac ttcctaccac tgacatgaca      720

gaaaatgtgc ttttatctaa gcagggattc agagagaata ctgaacccag cagtacccag      780

tttcaggttc catcaaggcc tcgcgacata cataccatca aaattgatgg aaaagagtta      840

gcagccaaca gcagtagatc aaccactccg aggggaaaag accatgtatg ctttgcagag      900

aaccctgata caataaagga ttcttccttt ggactacagc acagtcttaa ttcaggacag      960

agtttagagt ctgtaactct gaaaggcaga gctccacgga agcagatgtc ccttctgaac     1020

agttctgaat tccagcctca aattagaaca gttgccaaga gtcacagtga ctcatgcatt     1080

ctttcttcaa acaacctccc taccaaggat cttctttcag ctctgttaga acaaggcaat     1140

aaactgcgta atgccatggt gatttctgca atgaaatcaa gcccagagac cagcatgttg     1200

ttggaccaag ttcatcctct attaatgaag attctcttag agcatcaaca cagatcagag     1260

ccttttctag gaatcggttt aaagaccaca ttgaagatca cctcctccct tcaactgaga     1320

atacattttg gagacatgac acaaaagctg ataccagagc tatacagctg ctattaggca     1380

gtgctgaatt atcccaaggc aatttctggg atgggctagg ctctcctcca gattccccat     1440

ctcctgggag tgatgtgtat tgcatcagtg agctgaatga ccctcagtat gaccagagtc     1500

ttctggagaa tttattttat acagcaccta aatctgatac cagcatcagt gatttcctca     1560

gtgaagagga tgatatcgtc ccttctaaaa aaataagcca gtcaacagct cttgccagat     1620

catctaaggt tctggagtca agtgatcata agctgaagaa gaggtcagca ggcaagagaa     1680

atagaaattt ggttgaacaa cagatgctct cagaaactcc agaagatgcc caaacgatga     1740

cactaagtgt ggatagactg gcccttttgg gtagaacaca ttcagtcaga atcatcatcg     1800

aaaccatggg agttcctcca gatagtcctc agatgacccc tggcaaaaaa agctatgctg     1860

gtccaccacc taaggtgact acagcaaaaa agcgcacttt ctttgtagaa tatcactttc     1920

ctgtgggctt ttcggaaagc ggattgggaa agacagcttt gatcactgag gttgttcgac     1980

tcgcctccag taaaattaca gatggaagta agagacacac tggttttctg caccttagac     2040

attctgactt tggaagaatt tttgaattcc taattactca tttgactttt tttttttttt     2100

tttttttgac atggagtctc actctttcgc ccaggctgga gtgtggtggc gcaatctctg     2160

ctcactgcag cctccacctc ccgggttcaa gtgattctcc catctcagcc tcctgagtag     2220

ctgggattac aggcgtatgc caccacaccc agctaatttt tgtatttttt agtagagaca     2280

gggtttcacc atgttggcca gggtggtctc aaacccctga ccttaagtga tccgcctgcc     2340

tcggcctccc aaagtgctgg gattacaggc ataagccatc acgcccagcc aatattttca     2400

aggctgtgca accatcacca caatctaatt ttagaacatt ttcatccccc ctaaaagaaa     2460

ccccatactt actagcattc gcttcgcatt tccctcttcc cccagcccta agcaactgct     2520

aatctttctt tccctatcaa tttgtccatt ctggatgtct catataaatg gaatcatgca     2580

acttgt                                                                2586


<210> 600
<211> 4716
<212> DNA
<213> Homo sapiens

<400> 600
aggcggctgg gcgatgcgct tgcgcactga gaactcacac catatgtgtc ctgttccagt       60

gcgcgggtct gtggagagcc gggtgcgagc ggcggcagca cgaggggaaa agagctgagc      120

ggagaccaaa gtcagccggg agacagtggg tctgtgagag accgaataga ggggctgggg      180

ccacgagcgc cattgacaag caatggggaa gaaacagaaa aacaagagcg aagacagcac      240

caaggatgac attgatcttg atgccttggc tgcagaaata gaaggagctg gtgctgccaa      300

agaacaggag cctcaaaagt caaaagggaa aaagaaaaaa gagaaaaaaa agcaggactt      360

tgatgaagat gatatcctga aagaactgga agaattgtct ttggaagctc aaggcatcaa      420

agctgacaga gaaactgttg cagtgaagcc aacagaaaac aatgaagagg aattcacctc      480

aaaagataaa aaaaagaaag gacagaaggg caaaaaacag agttttgatg ataatgatag      540

cgaagaattg gaagataaag attcaaaatc aaaaaagact gcaaaaccga aagtggaaat      600

gtactctggg agtgatgatg atgatgattt taacaaactt cctaaaaaag ctaaagggaa      660

agctcaaaaa tcaaataaga agtgggatgg gtcagaggag gatgaggata acagtaaaaa      720

aattaaagag cgttcaagaa taaattcttc tggtgaaagt ggtgatgaat cagatgaatt      780

tttgcaatct agaaaaggac agaaaaaaaa tcagaaaaac aagccaggtc ctaacataga      840

aagtgggaat gaagatgatg acgcctcctt caaaattaag acagtggccc aaaagaaggc      900

agaaaagaag gagcgcgaga gaaaaaagcg agatgaagaa aaagcgaaac tgcggaagct      960

gaaagaaaaa gaagagttag aaacaggtaa aaaggatcag agtaaacaaa aggaatctca     1020

aaggaaattt gaagaagaaa ctgtaaaatc caaagtgact gttgatactg gagtaattcc     1080

tgcctctgaa gagaaagcag agactcccac agctgcagaa gatgacaatg aaggagacaa     1140

aaagaagaaa gataagaaga aaaagaaagg agaaaaggaa gaaaaagaga aagagaagaa     1200

aaaaggacct agcaaagcca ctgttaaagc tatgcaagaa gctctggcta agcttaaaga     1260

ggaagaagaa agacagaaga gagaagagga agaacgtata aaacggcttg aagaattaga     1320

agccaagcgt aaagaagagg aacgattgga acaagaaaaa agagaaagga aaaagcaaaa     1380

agaaaaagaa agaaaagaac gcttgaaaaa agaagggaaa cttttaacta aatcccagag     1440

agaagccaga gccagagccg aagctactct taaactgcta caagctcagg gtgttgaagt     1500

gccatcaaaa gactctttgc caaagaagag gccaatttat gaagataaaa agaggaaaaa     1560

aataccacag cagctagaaa gtaaagaagt gtctgaatca atggaattat gtgctgctgt     1620

agaagttatg gaacaaggag taccagaaaa ggaagagaca ccacctcctg ttgaaccaga     1680

agaagaagaa gatactgagg atgctggatt ggatgattgg gaagctatgg ccagtgatga     1740

ggagacagaa aaagtagaag gaaacaaagt tcatatagaa gtaaaagaaa accctgaaga     1800

ggaggaggag gaggaagaag aggaagaaga agatgaagaa agtgaagaag aggaggaaga     1860

ggagggagaa agtgaaggca gtgaaggtga tgaggaagat gaaaaggtgt cagatgagaa     1920

ggattcaggg aagacattag ataaaaagcc aagtaaagaa atgagctcag attctgaata     1980

tgactctgat gatgatcgga ctaaagaaga aagggcttat gacaaagcaa aacggaggat     2040

tgagaaacgg cgacttgaac atagtaaaaa tgtaaacacc gaaaagctaa gagcccctat     2100

tatctgcgta cttgggcatg tggacacagg gaagacaaaa attctagata agctccgtca     2160

cacacatgta caagatggtg aagcaggtgg tatcacacaa caaattgggg ccaccaatgt     2220

tcctcttgaa gctattaatg aacagactaa gatgattaaa aattttgata gagagaatgt     2280

acggattcca ggaatgctaa ttattgatac tcctgggcat gaatctttca gtaatctgag     2340

aaatagagga agctctcttt gtgacattgc cattttagtt gttgatatta tgcatggttt     2400

ggagccccag acaattgagt ctatcaacct tctcaaatct aaaaaatgtc ccttcattgt     2460

tgcactcaat aagattgata ggttatatga ttggaaaaag agtcctgact ctgatgtggc     2520

tgctacttta aagaagcaga aaaagaatac aaaagatgaa tttgaggagc gagcaaaggc     2580

tattattgta gaatttgcac agcagggttt gaatgctgct ttgttttatg agaataaaga     2640

tccccgcact tttgtgtctt tggtacctac ctctgcacat actggtgatg gcatgggaag     2700

tctgatctac cttcttgtag agttaactca gaccatgttg agcaagagac ttgcacactg     2760

tgaagagctg agagcacagg tgatggaggt taaagctctc ccggggatgg gcaccactat     2820

agatgtcatc ttgatcaatg ggcgtttgaa ggaaggagat acaatcattg ttcctggagt     2880

agaagggccc attgtaactc agattcgagg cctcctgtta cctcctccta tgaaggaatt     2940

acgagtgaag aaccagtatg aaaagcataa agaagtagaa gcagctcagg gggtaaagat     3000

tcttggaaaa gacctggaga aaacattggc tggtttaccc ctccttgtgg cttataaaga     3060

agatgaaatc cctgttctta aagatgaatt gatccatgag ttaaagcaga cactaaatgc     3120

tatcaaatta gaagaaaaag gagtctatgt ccaggcatct acactgggtt ctttggaagc     3180

tctactggaa tttctgaaaa catcagaagt gccctatgca ggaattaaca ttggcccagt     3240

gcataaaaaa gatgttatga aggcttcagt gatgttggaa catgaccctc agtatgcagt     3300

aattttggcc ttcgatgtga gaattgaacg agatgcacaa gaaatggctg atagtttagg     3360

agttagaatt tttagtgcag aaattattta tcatttattt gatgccttta caaaatatag     3420

acaagactac aagaaacaga aacaagaaga atttaagcac atagcagtat ttccctgcaa     3480

gataaaaatc ctccctcagt acatttttaa ttctcgagat ccgatagtga tgggggtgac     3540

ggtggaagca ggtcaggtga aacaggggac acccatgtgt gtcccaagca aaaattttgt     3600

tgacatcgga atagtaacaa gtattgaaat aaaccataaa caagtggatg ttgcaaaaaa     3660

aggacaagaa gtttgtgtaa aaatagaacc tatccctggt gagtcaccca aaatgtttgg     3720

aagacatttt gaagctacag atattcttgt tagtaagatc agccggcagt ccattgatgc     3780

actcaaagac tggttcagag atgaaatgca gaagagtgac tggcagctta ttgtggagct     3840

gaagaaagta tttgaaatca tctaattttt tcacatggag caggaactgg agtaaatgca     3900

atactgtgtt gtaatatccc aacaaaaatc agacaaaaaa tggaacagac gtatttggac     3960

actgatggac ttaagtatgg aaggaagaaa aataggtgta taaaatgttt tccatgagaa     4020

accaagaaac ttacactggt ttgacagtgg tcagttacat gtccccacag ttccaatgtg     4080

cctgttcact cacctctccc ttccccaacc cttctctact tggctgctgt tttaaagttt     4140

gcccttcccc aaatttggat ttttattaca gatctaaagc tctttcgatt ttatactgat     4200

taaatcagta ctgcagtatt tgattaacca agcttctgca gattttgtga ttcttgggac     4260

ttttttgacg taagaaatac ttctttattt atgcatattc ttcccacagt gatttttcca     4320

gcattcttct gccatatgcc tttagggctt ttataaaata gaaaattagg cattctgata     4380

tttctttagc tgctttgtgt gaaaccatgg tgtaaaagca cagctggctg ctttttactg     4440

cttgtgtagt cacgagtcca ttgtaatcat cacaattcta aaccaaacta ccaataaaga     4500

aaacagacat ccaccagtaa gcaagctctg ttaggcttcc atgttagtgt agcttctctc     4560

ccacaagttg tcctcctagg acaagaatta tcttacaaac taaactatca tcacactacc     4620

ttgtatgcca gcacctggta acagtagaga tttttataca ttaatcttga tctgttttaa     4680

tcttgatctg ttttagtaga gatttttata cattaa                               4716


<210> 601
<211> 685
<212> DNA
<213> Homo sapiens

<400> 601
ggcggggcct gctgggtggc ttagcactgc agggctctgc gcgggaacgc taacctggtc       60

cggagcgagt ctgggtctca gccccgcgaa cagcctttca cgagtcttca agctttcagg      120

ctatcttcta gtcaagatga gtgataagcc agacttgtcg gaagtggaga agtttgacag      180

gtcaaaactg aagaaaacta atactgaaga aaaaaatact cttccctcaa aggaaactat      240

ccagcaagag aaagagtgtg ttcaaacatc ataaaatggg gatcgcctcc caacagcaga      300

tttcgacatt acctgagagt cttgatttta ggcttgtttt ttgtaaaccc atgtgtttgt      360

agagatttta ggcgtcttcg gatatcttct cacctatgtt ccctggctaa gaagtcagag      420

gtagccaatg tttccttaaa ttcattttta aacttaccat tggtgcatat gttccagatg      480

gcagatgctg tcaataatct caccattgat gacctttgtg tatgtagttc ttgcatccta      540

tactggataa gcctgtttta acctgctatg atgggtgctt ccattgcttc ataatcttca      600

tgaagttgca tgcttttgca gcttttcaca gtttatttgc atttctaatg tagtaataaa      660

gtaaccaata taatcattat cttga                                            685


<210> 602
<211> 2599
<212> DNA
<213> Homo sapiens

<400> 602
cctcgctttc gctgggcgct gtccctctcc gcggcggtct ggtttccccg acgtgttttg       60

tttgcgacgc tgtcgtgtaa cagcgcgctt tacggccgcg gggacggagc gagccggcgc      120

cagggcccct cgggccggga agaggggaag gggagcgagg ttgatgcccg gcggaggggc      180

gagcgcggcg tctggccggc ttctcaccgc cgcggagcaa agagggtccc gggaagcggc      240

agggtcggcg tccaggagcg gcttcggggg ctccggcggc ggcagaggcg gagcaagcgg      300

ccccgggtcc gggagcggag gcccgggggg ccccgcgggc aggatgagct tgaccccgaa      360

ggagctctcg agcctgctga gcatcatatc ggaggaggcg ggcggcggca gcaccttcga      420

gggcctgtcc accgccttcc accactactt cagcaaggcc gaccacttcc gcctgggctc      480

ggtgctcgtc atgctgctcc agcagcccga cctgctgcct agcgcggcgc agcgcctcac      540

ggcgctctac ctgctctggg agatgtaccg caccgagccg ctggccgcca accccttcgc      600

cgccagcttc gcgcacctgc tcaaccccgc gccgcccgcc cgcggcggcc aggaacccga      660

ccgccctccg ctctcaggat ttttacctcc tataactcca ccagaaaagt tttttctttc      720

ccagctgatg ctggcacccc cacgggaact cttcaaaaag acgcctcgcc agattgcact      780

gatggacgtt ggaaacatgg gccagtctgt ggacattagt gggcttcagt tagccttggc      840

cgaacgccaa tctgaattgc caacgcaaag caaagcgagc ttccccagta ttctcagtga      900

cccagacccg gattcttcta attctggatt tgacagctca gttgcctctc agatcacaga      960

agctttagtc agcggaccaa agccacctat tgaaagccat tttcgaccag agtttattcg     1020

tccaccgcct ccactccaca tttgtgagga tgaacttgct tggctaaacc ccacggagcc     1080

tgaccacgcg atccagtggg ataaatcgat gtgtgttaag aatagcactg gtgtggagat     1140

caaacgaata atggccaaag ccttcaaaag ccccttatcc tctccccaac aaacacagct     1200

acttggtgag ttggaaaaag accccaaact tgtctaccat attggcctca ccccagccaa     1260

acttcctgac cttgtggaaa acaacccttt agtcgctata gaaatgttgc tgaaattaat     1320

gcagtcaagc cagatcactg agtatttctc tgtcctggtc aatatggaca tgtctttaca     1380

ttcaatggaa gttgtaaatc gactaactac agctgttgat ctacctcctg aatttattca     1440

cctttatata tcaaattgca tctctacttg tgaacagatt aaggataaat atatgcagaa     1500

tcggttggtg cgtcttgtgt gtgtgtttct ccaatccttg atccgtaaca aaattattaa     1560

tgtacaggat ttgtttatag aagtgcaggc attctgtatt gaattcagta ggatacgaga     1620

agctgctggt cttttccggt tgttgaagac attggatact ggggaaacac cttctgagac     1680

caaaatgtca aaataatacc tcatcagaac catcccatcc attcactgtt cagctgtact     1740

gtgatttagt ttttacaccg ttaaaaccct gagtggattg cttggtttaa tgcatataaa     1800

cagtacttta tctacttaaa gcaaagtttt gctttcttga atgacttttt ctgtgagatg     1860

aatttttgat aagaactagg gaaaacatgt cttttaggtg tcttgctgat gactatccat     1920

aggaggaatg gctatcccaa aaaaagttcc gcaaaaaagt agatgagttt cttttttttt     1980

taagcactaa agaacaaaat gcatttttca ttaatacagg cttctgatga accaggaatc     2040

ctgttttcgt aaagttccaa tgttgatgag agtaaattct taagcatttg tcctagaggt     2100

gaaagcagct gaatgtttct gaaccatcaa gaggcaaaca aacaggagtt tgtttcttga     2160

acctgcttat gcacacagct cttaactcct catgaggcac acagctctta actcctgatg     2220

aaccaaggat ttactcataa ctttctcctt gtcatggagg cttaatagac aacagaataa     2280

atgcatttct tgggcctctt ataaacttgg gaattcttag aaagctgctt ctattaccag     2340

gctgtaatag ctggtatagt tttttttttt tctcttaaga tgttctgtta ttagtctgag     2400

acagccattt ttttgtttta aggaaaaata tcagtcagtg ctccgggagg taatttcctg     2460

tggggtctgc accctcctgt ctgggtggtg gatgtgggtt tgagaagtag gagagcaggg     2520

tggtaccgtg tgggctctta ccctttatgt gattttggac aacagtgcct tccattaaag     2580

ttctttttat caactgtta                                                  2599


<210> 603
<211> 3301
<212> DNA
<213> Homo sapiens

<400> 603
gcgcgggccg ggccgggcgg cggcggcggc accatgagcg gccggaagcg cagcttcacc       60

ttcggggcct acggcggggt ggacaagtcc ttcacttctc gccggagtgt gtggaggagc      120

gatgggcaga accagcactt ccctcaggca ctagacctgt cacgagtgaa cttagttccc      180

tcctatactc cttcactcta ccctaagaac acagatctat ttgagatgat tgagaagatg      240

cagggaagca ggatggatga acaacgctgc tccttcccgc cgcccctcaa aacagaggag      300

gactacattc catacccgag cgtgcacgag gtcttggggc gagaaggacc cttccccctc      360

atcctgctgc cccagtttgg gggctactgg attgagggca ccaaccacga aatcaccagc      420

atccccgaga cagagccact gcagtcgccc acaaccaagg tgaagctcga gtgcaacccc      480

acagcccgca tctaccggaa gcactttctc ggcaaggagc atttcaatta ctactcactg      540

gacgctgccc tcggccacct tgtcttctca ctcaagtacg atgtcatcgg ggaccaagag      600

cacctgcggc tgctgctcag gaccaagtgc cggacatacc atgatgtcat ccccatctcc      660

tgcctcaccg agttccctaa tgttgtccag atggcaaagt tggtgtgtga agacgtcaat      720

gtggatcggt tctatcctgt gctctacccc aaggcttccc ggctcatcgt cacctttgac      780

gagcatgtca tcagcaataa cttcaagttt ggcgtcattt atcagaagct tgggcagacc      840

tccgaggaag aactcttcag caccaatgag gaaagtcccg ctttcgtgga gttccttgaa      900

tttcttggcc agaaggtcaa actgcaggac tttaaggggt tccgaggagg cctggacgtg      960

acccacgggc agacggggac cgaatctgtg tactgcaact tccgcaacaa ggagatcatg     1020

tttcacgtgt ccaccaagct gccatacacg gaaggggacg cccagcagtt gcagcggaag     1080

cggcacatcg ggaacgacat cgtggctgtg gtcttccagg atgagaacac tcctttcgtg     1140

cccgacatga tcgcgtccaa cttcctgcat gcctacgtcg tggtgcaggc tgagggcggg     1200

ggccctgatg gccccctcta caaggtctct gtcactgcaa gagatgatgt gcccttcttt     1260

ggaccccccc tcccggaccc cgctgtgttc aggaaggggc ctgagttcca ggaatttttg     1320

ctgacaaagc tgatcaatgc tgaatatgcc tgctacaagg cagagaagtt tgccaaactg     1380

gaggagcgga cgcgggccgc cctcctggag acgctctatg aggaactaca catccacagc     1440

cagtccatga tgggcttggg cggcgacgag gacaagatgg agaatggcag tgggggcggc     1500

ggcttctttg agtctttcaa gcgggtcatc cggagccgca gccagtccat ggatgccatg     1560

gggctgagca acaagaagcc caacaccgtg tccaccagcc acagcgggag cttcgcgccc     1620

aacaaccccg acctggccaa ggcggctgga atatcactga ttgtccctgg gaagagcccc     1680

acgaggaaga agtcgggccc gttcggctcc cgccgcagca gcgccattgg catcgagaac     1740

atacaggagg tgcaggagaa gagggagagc cctccggctg gtcagaagac cccagacagc     1800

gggcacgtct cacaggagcc caagtcggag aactcatcca ctcagagctc cccagagatg     1860

cccacgacca agaacagagc ggagaccgca gcgcagagag cagaggcgct caaggacttc     1920

tcccgctcct cgtccagtgc cagcagcttc gccagcgtgg tggaggagac ggagggtgtg     1980

gacggagagg acacaggcct ggagagcgtg tcatcctcag gaacacccca caagcgggac     2040

tccttcatct atagcacgtg gctggaggac agtgtcagca ccactagtgg gggcagctcc     2100

ccaggcccct ctcgatcacc ccacccagac gccggcaagt tgggggaccc tgcgtgtccc     2160

gagatcaaga tccagctgga agcatctgag cagcacatgc cccagctggg ctgttagccg     2220

ggccaccccc tctgaaggtg aaactgagca gatgaggcca cagaagcaca aggggaaggt     2280

gccgtgtcaa gcccaggcag acgagacctc tgccctgaag accaacacca gcccgtgggc     2340

tgccccctgc ctccccaccc tccccatggc ccacccatct gggctgtctc tgcagggcag     2400

agccgtccag acctgggatc agggaagctg ctggcatcgt ccccaccccc agcctggggg     2460

tctgggctgg ggcagggatt gctcagtgga agcaggactg ggggtctggc ttgccccctc     2520

cctgggcctc catcacccct gagcatccct ctggactcag agggaacaag gtgggagaga     2580

gagtttgaga cagctccgtg tggagagctt agcccctgga ggcagcacaa ggaggatgtg     2640

atatgtgggg gagtgagcac tgggttggga gccgggtcct ggtttccaat ttgggttctg     2700

ctgtgtgact ctgggcaagt cactctccct ctctgggcat gtctgctaca aatggacaag     2760

attatttcag aggtcactga agactgtgat tacatgcacc tgccttagaa ggtaggattt     2820

tcttcccagg gacctcctat caccctaccc tgcttcttga ggtccctgga gccccaggtg     2880

ggctgagggg cagggagccg gctgtgccca gtatgcctcc tggaccctcc agttctgcca     2940

caggtctgcc gatgccctgt ccactgccta cacatgacag acaagtaacc ccctcatggg     3000

ggatggggac ctacctggct cctcagccag cacccagctt aacccctgcc atcccatgct     3060

gggccctcca ggccaagagt ctcagctggc cgagagtcca ggccttgcct cccccgaccg     3120

ccatggaggg ggcagcccgg cacagctgct gggagccctt gtgtgtctgg tcacactttt     3180

taggcgtcac gccaaaggcc agcctcctgg ccccaatacc cattttggaa gcccctgtgg     3240

ccgtgtggat gtcggtaaca gttgtataaa ataaattcta tttatcgcta ttgtacccag     3300

a                                                                     3301


<210> 604
<211> 1692
<212> DNA
<213> Homo sapiens

<400> 604
tggagactga aagcggcgga agggacgctg gaatgtggag cggttgtggg gcggcagctg       60

cggaactgcg cgattgtggt tcccgccgta tttcccgttc cccatctagt aactcccatc      120

tcagcccacg tatctccctg agtggaaatc tcgggcccca gaccagtcga ttgggaggtc      180

cgccctcccc ttcagcgact tggtctgtgt tttggcagtt gccgcgacaa cagtcacttc      240

cgggaagggg ctctgcgaat ctccttccgt cggtccgctc agaatcagct gtcctctcag      300

actgtgtggg tggtttcccc ggccgcagct ccgtacgggc ttggattgct gggcctcggt      360

gcaccccagc ctcccccact cgggttctga gcttgagctg gcggctcttt aactctgctt      420

cactgttgct cttggcaaca tccacttccg ggagcgagtg ccgtttcccc cgctcaccgc      480

gggctaggga gcgtgggatt ccggactgtg agcggctgtt agtgcgtcgc agctgctggc      540

gatccggcga ccctcggccg gcaggacccg cgggccacgc agccggggcc ttctcaacgc      600

ctcagtacct cggcgggacc gccatggttc tgctgcacgt gaagcggggc gacgagagcc      660

agttcctgct gcaggcgcct gggagtaccg agctggagga gctcacggtg caggtggccc      720

gggtctataa tgggcggctc aaggtgcagc gcctctgctc agaaatggaa gaattagccg      780

aacatggcat atttctccct cctaatatgc aaggactgac cgatgatcag attgaagaat      840

tgaaattgaa ggatgaatgg ggtgaaaaat gcgtacccag cggaggtgca gtgtttaaaa      900

aggatgatat tggacgaagg aatgggcaag ctccaaatga gaagatgaag caagtgttaa      960

agaagactat agaagaagcc aaagcaataa tatctaagaa acaagtggaa gccggtgtct     1020

gtgttaccat ggagatggtg aaagatgcct tggaccagct tcgaggcgcg gtgatgattg     1080

tttaccccat ggggttgcca ccgtatgatc ccatccgcat ggagtttgaa aataaggaag     1140

acttgtcggg aacacaggca gggctcaacg tcattaaaga ggcagaggcg cagctgtggt     1200

gggcagccaa ggagctgaga agaacgaaga agctttcaga ctacgtgggg aagaatgaaa     1260

aaaccaaaat tatcgccaag attcagcaaa ggggacaggg agctccagcc cgagagccta     1320

ttattagcag tgaggagcag aagcagctga tgctgtacta tcacagaaga caagaggagc     1380

tcaagagatt ggaagaaaat gatgatgatg cctatttaaa ctcaccatgg gcggataaca     1440

ctgctttgaa aagacatttt catggagtga aagacataaa gtggagacca agatgaagtt     1500

caccagctga tgacacttcc aaagagatta gctcaccttt ctcctaggca attataattt     1560

aaaaaaaaaa aaaaggccac ttactgccct ctgtaaaaga tgttaacatt tctagttttc     1620

ttttagtgtg aatttttaaa atagcagtta ttcaaggttt tagaacttaa taaataccta     1680

gtcagaagaa aa                                                         1692


<210> 605
<211> 1161
<212> DNA
<213> Homo sapiens

<400> 605
gagaggccca agatggagac ggcggcggct gtagcggcgt gacaggagcc ccatggcacc       60

tgcccagccc cacctcagcc catcttgaca aaatctaagg ctccatggag ccaccacggg      120

gcccccctgc caatggggcc gagccatccc gggcagtggg caccgtcaaa gtatacctgc      180

ccaacaagca acgcacggtg gtgactgtcc gggatggcat gagtgtctac gactctctag      240

acaaggccct gaaggtgcgg ggtctaaatc aggactgctg tgtggtctac cgactcatca      300

agggacgaaa gacggtcact gcctgggaca cagccattgc tcccctggat ggcgaggagc      360

tcattgtcga ggtccttgaa gatgtcccgc tgaccatgca caattttgta cggaagacct      420

tcttcagcct ggcgttctgt gacttctgcc ttaagtttct gttccatggc ttccgttgcc      480

aaacctgtgg ctacaagttc caccagcatt gttcctccaa ggtccccaca gtctgtgttg      540

acatgagtac caaccgccaa cagttctacc acagtgtcca ggatttgtcc ggaggctcca      600

gacagcatga ggctccctcg aaccgccccc tgaatgagtt gctaaccccc cagggtccca      660

gctgccggta gtagaggagg tagtgatgga accccccggg ggagccccag cccagccagc      720

gtgtcctcgg ggaggaagtc cccacattcc aagtcaccag cagagcagcg cgagcggaag      780

tccttggccg atgacaagaa gaaagtgaag aacctggggt accgggactc aggctattac      840

tgggaggtac cacccagtga ggtgcagctg ctgaagagga tcgggacggg ctcgtttggc      900

accgtgtttc gagggcggtg gcatggcgat gtggccgtga aggtgctcaa ggtgtcccag      960

cccacagctg agcaggccca ggctttcaag aatgagatgc aggtgctcag gaagacgcga     1020

catgtcaaca tcttgctgtt tatgggcttc atgacccggc cgggatttgc catcatcaca     1080

cagtggtgtg agggctccag cctctaccat cacctgcatg tggccgacac acgcttcgac     1140

atggtccagc tcatcgacgt g                                               1161


<210> 606
<211> 2410
<212> DNA
<213> Homo sapiens

<400> 606
agcgcgagcc ccgccgccgc cgagcatgga cgaccccgac tgcgactcca cctgggagga       60

ggacgaggag gatgcggagg acgcggagga cgaggactgc gaggacggcg aggccgccgg      120

cgcgagggac gcggacgcag gggacgagga cgaggagtcg gaggagccgc gggcggcgcg      180

gcccagctcg ttccagtcca gaatgacagg gtccagaaac tggcgagcca cgagggacat      240

gtgtaggtat cggcacaact atccggatct ggtggaacga gactgcaatg gggacacgcc      300

aaacctgagt ttctacagaa atgagatccg cttcctgccc aacggctgtt tcattgagga      360

cattcttcag aactggacgg acaactatga cctccttgag gacaatcact cctacatcca      420

gtggctgttt cctctgcgag aaccaggagt gaactggcat gccaagcccc tcacgctcag      480

ggaggtcgag gtgtttaaaa gctcccagga gatccaggag cggcttgtcc gggcctacga      540

gctcatgctg ggcttctacg ggatccggct ggaggaccga ggcacgggca cggtgggccg      600

agcacagaac taccagaagc gcttccagaa cctgaactgg cgcagccaca acaacctccg      660

catcacacgc atcctcaagt cgctgggtga gctgggcctc gagcacttcc aggcgccgct      720

ggtccgcttc ttcctggagg agacgctggt gcggcgggag ctgccggggg tgcggcagag      780

tgccctggac tacttcatgt tcgccgtgcg ctgccgacac cagcgccgcc agctggtgca      840

cttcgcctgg gagcacttcc ggccccgctg caagttcgtc tgggggcccc aagacaagct      900

gcggaggttc aagcccagct ctctgcccca tccgctcgag ggctccagga aggtggagga      960

ggaaggaagc cccggggacc ccgaccacga ggccagcacc cagggtcgga cctgtgggcc     1020

agagcatagc aagggtgggg gcagggtgga cgaggggccc cagccacgga gcgtggagcc     1080

ccaggatgcg ggacccctgg agaggagcca gggggatgag gcagggggcc acggggaaga     1140

taggccggag cccttaagcc ccaaagagag caagaagagg aagctggagc tgagccggcg     1200

ggagcagccg cccacagagc caggccctca gagtgcctca gaggtggaga agatcgctct     1260

gaatttggag gggtgtgccc tcagccaggg cagcctcagg acggggaccc aggaagtggg     1320

cggtcaggac cctggggagg cagtgcagcc ctgccgccaa cccctgggag ccagggtggc     1380

cgacaaggtg aggaagcgga ggaaggtgga tgagggtgct ggggacagtg ctgcggtggc     1440

cagtggtggt gcccagacct tggcccttgc cgggtcccct gccccatcgg ggcaccccaa     1500

ggctggacac agtgagaacg gggttgagga ggacacagaa ggtcgaacgg ggcccaaaga     1560

aggtacccct gggagcccat cggagacccc aggccccagc ccagcaggac ctgcagggga     1620

cgagccagcc gagagcccat cggagacccc aggcccccgc ccagcaggac ctgcagggga     1680

cgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga     1740

cgagccagcc gagagcccat cggagacccc aggccccagc ccggcaggac ctacaaggga     1800

tgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga     1860

cgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga     1920

cgagccagcc gagagcccat cggagacccc aggccccagc ccggcaggac ctacaaggga     1980

tgagccagcc aaggcggggg aggcagcaga gttgcaggac gcagaggtgg agtcttctgc     2040

caagtctggg aagccttaag gaaaggagtg cccgtcggcg tcttggtcct cctgtccctg     2100

ctgcaggggc tggggcctcc ggagctgctg cgggctcccc tcaggctctg cttcgtgacc     2160

cgtgacccat gacccacagt gctggcctcc tgtggggcca ctatagcagc caccagaagc     2220

cgcgaggccc tcagggaagc ccaaggcctg cagaagcctc ctggcctggc tgtgtcttcc     2280

ccacccagct ctcccctgcg cccctgtctt tgtaaattga cccttctgga gtggggggcg     2340

gcgggcaggg ctgcttttct tagtctgata ccaagcaagg ccttttctga ataaattcat     2400

ttgactttga                                                            2410


<210> 607
<211> 1099
<212> DNA
<213> Homo sapiens

<400> 607
ccacaccgcg ctcagcgcct tcactgccat ccccgctgtc cttgccgccc ccgccatggg       60

cctagagctg tttcttgacc tggtgtccca gcccagccgc gccgtctaca tcttcgccaa      120

gaagaatggc atccccttag agctgcgcac cgtggatttg gtcaaagggc agcacaagag      180

caaggagttc ttgcagatca acagcctggg gaaactgccg acgctcaagg atggtgattt      240

catcttgact gaaagctcgg ccatcctgat ttacctgagc tgtaagtacc agacgccgga      300

ccactggtat ccatctgacc tgcaggctcg tgcccgtgtt catgagtacc tgggctggca      360

tgccgactgc atccgtggca cctttggtat acccctgtgg gtccaggtgt tggggcccct      420

cattggggtc caggtgcccg aggagaaggt ggaacgcaac aggactgcca tggaccaggc      480

cctgcaatgg ctggaggaca agttcctggg ggacaggccc ttcctcgctg gccagcaggt      540

gacactggct gatctcatgg ccctggagga gctgatgcag ccggtggctc tcggctatga      600

actgtttgag ggacggccac gactggcagc atggcgtgga cgagtggagg ctttcctggg      660

tgctgagcta tgccaggagg cccacagcat catcttgagc atcctggaac aggcggccaa      720

gaaaaccctc ccaacaccct caccagaggc ctatcaggct atgctgcttc gaatcgccag      780

gatcccctga agggtctggg atgggggcca ggagattagc aacaaggatt cattctgtta      840

cttacttgcc cctttttatc tttccctctt gccccagtcc cttctctcca gcttcatgtg      900

aagctctgca cagacaagac actcagtgtc cttggcagtg ctgctactcc tcaggtgcag      960

catacataac cagtaagaga ctaaatctgc aatatataaa gagctcctac aaatcagtaa     1020

catgaagaac actcaaaaat tggcaaatgt catcagtgtt ttaaacagaa taaagattcc     1080

aaacactttg aatagagaa                                                  1099


<210> 608
<211> 1089
<212> DNA
<213> Homo sapiens

<400> 608
cccgggagcc ggcagggagc ggagctgcgg agccgcctgg tctcccgcgt ccatcggtcc       60

attcctgcgt cgttctgtcc ttccgaacgc acacttcagg agcagccgcg aggagtgagc      120

actgcacgca ggatccgccc agtgcttggg ccaagcaccc tgtggcatcc aagctcccct      180

ggacgttacc cttggtgaac caaggtggca tggcagcgag cacagacatg gctgggctgg      240

aggagagctt ccgcaagttt gccatccatg gtgaccccaa ggccagtggg caagagatga      300

atggcaagaa ctgggccaag ctgtgcaagg actgcaaggt ggctgacgga aagtccgtga      360

cagggaccga tgtggacatc gtcttctcca aagtcaaggg gaagtctgct cgggtcatca      420

actatgagga gttcaagaag gccctggaag agctggcgac caagagattc aaggggaaga      480

gcaaggagga ggccttcgat gccatctgcc agctggtggc aggcaaagag ccagccaatg      540

tgggcgtcac taaagcaaaa acagggggtg ctgtagaccg gctgacggac accagcagat      600

acacgggctc ccacaaggag cgcttcgatg agagcggcaa gggcaagggc attgcgggac      660

ggcaggacat cctggacgac agtggctacg tgagcgccta caagaatgca ggcacctacg      720

atgccaaggt gaagaagtga ggcttgggaa gaccgccctg ccaagtgcgg ctgcccctgc      780

cagaggctca ggcctgggtc taaggggcac gtggagcaag agatcctggt cccctccctg      840

ctggacctgc cacccagagc ttcctgccta gtcccactgg gctggcccac caggcctctg      900

acccaggctg ctctgcggcc ccttcctcct cctcttcctg ctccaacttc tgtccacctg      960

gggacagtct gtgcctgtag cctcatgacc ccaacccagc cccaggcatg gctaacccct     1020

gactgcttgc ctcatattta agctgctgct ctggccaagt gcctaatttt aacccagacc     1080

tcaataaag                                                             1089


<210> 609
<211> 1430
<212> DNA
<213> Homo sapiens

<400> 609
tggctcctcc cgcttcgtcc gcgtcgcctg tccccgctcc ccatcttccg ggctgggagg       60

gaggcgggac cggccgcgtc tccatggcga cgcgggacgc ggcggtggag gcggttgcta      120

cccacctgct agaggcgctg cggctgtgat ccaggctggg gcgagaccat gtcggacctg      180

ggctcggagg agttggagga ggagggagag aatgatattg gggaatatga ggggggtcgg      240

aatgaggcag gcgaaaggca cggacgtggg agggcacggc tacccaacgg ggacacctac      300

gaagggagct acgaattcgg taaaagacat ggccagggga tctacaaatt taaaaatggt      360

gctcgatata tcggagaata tgttagaaat aaaaagcacg gtcaaggcac ttttatatat      420

ccagatggat ccagatatga aggagagtgg gcaaatgacc tgcggcacgg ccatggcgta      480

tactactaca tcaataatga cacctacact ggagagtggt ttgctcatca aaggcatggg      540

caaggcacct atttatacgc ggagacgggc agtaagtatg ttggcacctg ggtgaacgga      600

cagcaggagg gcacggccga gctcattcac ctgaaccaca ggtaccaggg caagttcttg      660

aacaaaaatc ctgttggccc tggaaagtat gtatttgatg ttgggtgtga acaacatggt      720

gaatatcgtt taacagatat ggaaagagga gaagaggaag aggaggaaga attagtaact      780

gttgttccaa aatggaaagc tacccaaatc actgaattgg ccctgtggac accaactctc      840

cccaaaaagc cgacctctac ggatggacct ggccaagacg ctccaggagc tgagagtgca      900

ggagaacccg gggaggaggc ccaggctctg ctggagggct tcgagggtga gatggacatg      960

aggcctggag atgaagatgc agacgtcctc cgggaagaga gccgggagta tgaccaggag     1020

gagttccgct atgacatgga tgagggaaac attaattctg aagaagaaga aactagacag     1080

tcagacctcc aggactaaga tgaagtgagc cgagaggaga tcgtatcata agaatgcttc     1140

tgtcgttagc cgggtgcagt gctgtgtgta tctagttcca gctacttgag aggctgaggc     1200

aggaggattg cttgagtcca gaaagtggca gttgcagtga gtggagatcg cgccactgct     1260

ctccagcctg ggtggcagag cgagaccctg tctcaaaaaa taaacaaaaa caaaatgctt     1320

ctgtcagtta acaatcttta ttagagggtt tttagtcttt ctttctcagc tgtatgttaa     1380

gttgattgac aaatgcaaat aaacgtcttt attatccttt ctttctgaaa                1430


<210> 610
<211> 6113
<212> DNA
<213> Homo sapiens

<400> 610
taatacttaa ttaccttcta ataattggag cagaagatga acccaactaa tcctttcagt       60

gggcagcagc ctagtgcttt ttcggcgtct tctagtaatg taggaacact tccatctaag      120

ccgccatttc gatttggtca accttctctt tttggacaaa acagtacctt atctgggaag      180

agctcgggat tttcacaggt atccagcttt ccagcgtctt ctggagtaag tcattcctct      240

tcagtgcaaa cattagggtt cacccaaacc tcaagtgttg gacccttttc tggacttgag      300

cacacttcca cctttgtggc tacctctggg ccttcaagtt catctgtgct gggaaacaca      360

ggatttagtt ttaaatcacc caccagtgtt ggggctttcc caagcacttc tgcttttgga      420

caagaagctg gagaaatagt gaactctggt tttgggaaaa cagaattcag ctttaaacct      480

ctggaaaatg cagtgttcaa accaatactg ggggctgaat ctgagccaga gaaaacccag      540

agccaaattg cttctgggtt ttttacattt tcccacccaa ttagtagtgc acctggaggc      600

ctggcccctt tctcttttcc tcaagtaaca agtagttcag ctaccacttc aaattttacc      660

ttttcaaaac ctgttagtag taataattca ttatctgcct ttacccctgc tttgtcaaac      720

caaaatgtag aggaagagaa gagaggacct aagtcaatat ttggaagttc taataatagc      780

ttcagtagct tccctgtatc atctgcggtt ttgggcgaac ctttccaggc tagcaaagca      840

ggtgtcaggc aggggtgtga agaagctgtt tcccaggtgg aaccacttcc cagcctaatg      900

aaaggactga aaaggaagga ggaccaggat cgctccccaa ggagacatgg ccacgagcca      960

gcagaagatt cggatcctct gtcccggggc gatcatcctc cagacaaacg acctgtccgc     1020

ctgaatcgac cccggggagg tactttattt ggtcggacga tacaggatgt tttcaaaagc     1080

aataaggaag taggtcgtct gggcaacaag gaggccaaaa aggaaactgg ctttgttgag     1140

tctgcagaaa gtgaccacat ggctatccca ggagggaatc agtctgtcct ggcaccttcc     1200

cggattccag gtgtgaataa agaggaagaa actgaaagta gagagaagaa agaagattct     1260

ctaagaggaa ctccggcgcg tcagagtaac agaagcgaga gcacagacag tcttgggggc     1320

ttgtctccct ctgaagtcac agccatccag tgcaagaaca tccctgacta cctcaacgac     1380

aggaccattc tggagaacca ttttggcaaa attgctaaag tgcagcgcat ctttaccagg     1440

cgcagcaaaa agcttgcagt ggtacatttc tttgatcatg catctgcagc cctggctaga     1500

aagaagggga aaagtttgca taaagacatg gctatctttt ggcacaggaa gaaaataagc     1560

cccaataaga aacccttttc cctgaaggag aagaaaccag gtgacggtga agtcagcccg     1620

agcacagagg atgcaccctt tcagcactct cctcttggca aggccgcagg gaggactggt     1680

gctagcagcc tcctgaataa aagctctcca gtgaagaagc caagtcttct aaaggcccac     1740

caattcgagg gagactcttt tgactcagcc tccgagggct ccgagggcct cgggccatgt     1800

gtgctctccc tcagtaccct gataggcact gtggctgaga catccaagga gaagtaccgc     1860

ctgcttgacc agagagacag gatcatgcgg caagctcggg tgaagagaac cgatctggac     1920

aaagcgagga cttttgttgg cacctgcctg gatatgtgtc ctgagaagga gaggtacatg     1980

cgggagaccc gtagccagct gagcgtgttc gaagtggtcc cagggactga ccaggtggac     2040

cacgcagcag ctgtgaaaga gtacagtcgg tcctcggcgg atcaggagga gcccctgccc     2100

cacgagctgc ggcccttgcc agtgctcagc aggaccatgg actacctggt gacccagatc     2160

atggaccaga aggagggcag cctgcgggat tggtatgact tcgtgtggaa ccgcacgcgt     2220

ggcatacgga aggatatcac gcagcagcac ctctgtgacc ccctgacggt gtccctgatt     2280

gagaagtgca cccggtttca catccactgt gcccacttca tgtgtgagga gcccatgtcc     2340

tcctttgatg ccaagatcaa taatgagaac atgaccaagt gcctgcagag cctgaaggag     2400

atgtaccagg acctgagaaa caagggtgtc ttctgtgcca gcgaagcgga gttccagggc     2460

tacaatgttc tgctcagtct caacaaggga gacatcctaa gagaagtaca acagttccat     2520

cctgctgtta gaaactcatc tgaggtgaaa tttgctgttc aggcttttgc tgcattgaac     2580

agtaataatt ttgtgagatt tttcaaactg gtccagtcag cttcttacct gaacgcttgt     2640

cttttacact gttacttcag tcagatccgc aaggatgctc tccgggcgct caactttgcg     2700

tacacggtga gcacacagcg atctaccatc tttcccctgg atggtgtggt gcgcatgctg     2760

ctgttcagag actgtgaaga ggccaccgac ttcctcacct gccacggcct caccgtttcc     2820

gacggctgtg tggagctgaa ccggtctgca ttcctggaac cagagggatt atccaagacc     2880

aggaagtcgg tgtttattac taggaagctg acggtgtcag tcggggaaat tgtgaacgga     2940

gggccattgc cccccgtccc tcgtcatacc cctgtgtgca gcttcaactc ccagaacaag     3000

tacatcgggg agagcctggc cgcggagctg cccgtcagca cccagagacc cggctccgac     3060

acagtgggcg gagggagagg agaggagtgt ggtgtagagc cggatgcacc cctgtccagt     3120

ctcccacagt ctctaccagc ccctgcgccc tcaccagtgc ctctgcctcc tgtcctggca     3180

ctgaccccgt ctgtggcgcc cagcctcttc cagctgtctg tgcagcctga accaccgcct     3240

ccagagcccg tgcccatgta ctctgacgag gacctggcgc aggtggtgga cgagctcatc     3300

caggaggccc tgcagaggga ctgtgaggaa gttggctctg cgggtgctgc ctacgcagct     3360

gccgccctgg gtgtttctaa tgctgctatg gaggatttgt taacagctgc aaccacgggc     3420

attttgaggc acattgcagc tgaagaagtg tctaaggaaa gagagcgaag ggagcaggag     3480

aggcagcggg ctgaagagga aaggttgaaa caagagagag agctggtgtt aagtgagctg     3540

agccagggcc tggccgtgga gctgatggaa cgcgtgatga tggagtttgt gagggaaacc     3600

tgctcccagg agttgaagaa tgcagtagag acagaccaga gggtccgtgt ggcccgttgc     3660

tgtgaggatg tctgtgccca cttagtggac ttgtttctcg tggaggaaat cttccagact     3720

gcaaaggaga ccctccagga gcttcagtgc ttctgcaagt atctacagcg gtggagggaa     3780

gctgtcacag cccgcaagaa actgaggcgc caaatgcggg ctttccctgc tgcgccctgc     3840

tgcgtggacg tgagcgaccg gctgagggcg ctggcgccca gcgcagagtg ccccattgct     3900

gaagagaacc tggccagggg cctcctggac ctgggccatg cagggagatt gggcatctcc     3960

tgcaccaggt taaggcggct cagaaacaag acagctcacc agatgaaggt tcagcacttc     4020

taccagcagc tgctgagtga tgtggcatgg gcgtctctgg acctgccatc cctcgtggct     4080

gagcacctcc ctgggaggca ggagcatgtg ttttggaagc tggtgctggt gttgccggat     4140

gtagaggagc agtccccaga gagttgtggc agaattctag caaattggtt aaaagtcaag     4200

ttcatgggag atgaaggctc agtggatgac acatccagcg atgctggtgg gattcagacg     4260

ctttcgcttt tcaactcact tagcagcaaa ggggatcaga tgatttctgt taacgtgtgt     4320

ataaaggtgg cccatggcgc cctcagtgat ggtgccattg atgctgtgga gacacagaag     4380

gacctcctgg gagccagtgg gctcatgctg ctgcttcccc ccaaaatgaa gagtgaggac     4440

atggcagagg aggacgtgta ctggctgtcg gccttgctgc agctcaagca gctcctgcag     4500

gctaagccct tccagcctgc gcttcctctg gtggttcttg tgcctagccc aggaggggac     4560

gccgttgaga aggaagtaga agatggtctg atgctacagg acttggtttc agctaagctg     4620

atttcagatt acactgttac cgagatccct gataccatta atgatctaca aggttcaact     4680

aaggttttgc aagcagtgca gtggctggtt tcccactgcc cccattccct tgacctctgc     4740

tgccagactc tcattcagta cgtcgaagac gggattggcc atgagtttag tggccgcttt     4800

ttccatgaca gaagagagag gcgtctgggc ggtcttgctt ctcaggagcc tggcgccatc     4860

attgagctgt ttaacagtgt gctgcagttc ctggcttctg tggtgtcctc tgaacagctg     4920

tgtgacctgt cctggcctgt cactgagttt gctgaggcag ggggcagccg gctgcttcct     4980

cacctgcact ggaatgcccc agagcacctg gcctggctga agcaggctgt gctcgggttc     5040

cagcttccgc agatggacct tccacccctg ggggccccct ggctccccgt gtgctccatg     5100

gttgtccagt acgcctccca gatccccagc tcacgccaga cacagcctgt cctccagtcc     5160

caggtggaga acctgctcca cagaacctac tgtaggtgga agagcaagag tccctcccca     5220

gtccatgggg caggcccctc ggtcatggag atcccatggg atgatcttat cgccttgtgt     5280

atcaaccaca agctgagaga ctggacgccc ccccggcttc ctgttacatc agaggcgctg     5340

agtgaagatg gtcagatatg tgtgtatttt tttaaaaacg atttgaaaaa atatgatgtt     5400

cctttgtcgt gggaacaagc caggttgcag acgcagaagg agctacagct gagagaggga     5460

cgtttggcaa taaagccttt tcatccttct gcaaacaatt ttcccatacc attgcttcac     5520

atgcaccgta actggaagag gagcacagag tgtgctcaag aggggaggat tcccagcaca     5580

gaggatctga tgcgaggagc ttctgctgag gagctcttgg cgcagtgttt gtcgagcagt     5640

ctgctgctgg agaaagaaga gaacaagagg tttgaagatc agcttcagca atggttgtct     5700

gaagactcag gagcatttac ggatttaact tcccttcccc tctatcttcc tcagactcta     5760

gtgtctcttt ctcacactat tgaacctgtg atgaaaacat ctgtaactac tagcccacag     5820

agtgacatga tgagggagca actgcagctg tcagaggcga caggaacgtg tctaggcgaa     5880

cgactaaagc acctggaaag gctgatccgg agttcaaggg aagaggaagt tgcctctgag     5940

ctccatctct ctgcgctgct agacatggtg gacatttgag cagcctgacc tgtggggagg     6000

gggtctctcc cgaagagttt ctgtttttac tcaaaataat gttattctca gatgcttgat     6060

gcactgttgg aaatgtgatt aatttaatca tgcagataaa ccatttaaat gtc            6113


<210> 611
<211> 3934
<212> DNA
<213> Homo sapiens

<400> 611
gtctcgtgtt tctctcttcc aatcggttgt ctttatcgtg gacactgagg tgttctctgc       60

cttgactaaa gatgagtgac gtgaatccac cctctgacac ccccattccc ttttcatcct      120

cctccactca cagttctcat attccgccct ggacattctc ttgctacccc ggctccccat      180

gtgaaaatgg ggtcatgctg tacatgagaa acgtgagcca tgaggagcta caacggttca      240

agcagctctt actgactgag ctcagtactg gcaccatgcc catcacctgg gaccaggtcg      300

agacagccag ctgggcagag gtggttcatc tcttgataga gcgtttccct ggacgacgcg      360

cttgggatgt gacttcgaac atctttgcca ttatgaactg tgataaaatg tgtgttgtag      420

tccgcagaga gataaatgcc attctgccta ccttggaacc agaggacttg aatgtgggag      480

aaacacaggt gaatctggag gaaggagaat ctggtaaaat acggcggtat aaatcgaatg      540

tgatggaaaa gtttttcccc atatgggaca ttacgacttg gcctggaaac cagagggact      600

tcttctacca aggtgtacac aggcacgagg agtacttacc atgtctgctt ctgcccaaaa      660

gaccccaggg tagacagccc aagaccgtgg ccatacaggg agctcctggg atcggaaaaa      720

caatcctggc caaaaaggtg atgtttgagt gggccagaaa caagttctac gcccacaagc      780

gctggtgtgc tttctacttc cattgccaag aggtgaacca gacgacagac cagagcttct      840

ccgagctgat tgagcaaaag tggcctggat ctcaggacct cgtgtcaaag attatgtcca      900

aacccgacca acttctgctg ctcttggatg gctttgagga gctcacatct accctcattg      960

acagactgga ggacctgagt gaagactgga ggcagaaatt gcctgggtct gtcctactga     1020

gcagtttgct gagcaaaacg atgcttccag aggccacgct actgatcatg ataagattta     1080

cctcttggca gacatgcaag cccttgctga aatgtccctc tctcgtaacc cttccggggt     1140

ttaatacgat ggaaaaaatc aagtatttcc agatgtattt tggacacaca gaggagggag     1200

accaagtctt gagtttcgcc atggaaaaca ccattctctt ctccatgtgc cgggtccctg     1260

tggtttgctg gatggtctgc tctggtctga aacagcaaat ggagagagga aacaatctca     1320

cacagtcatg tccaaatgcc acctctgtgt tcgtccggta tatttctagc ttgtttccca     1380

ccagagctga gaacttttcc agaaagatcc accaagcaca actggaaggt ctgtgtcact     1440

tggccgcaga cagcatgtgg cacaggaaat gggtgttagg taaagaagat cttgaggaag     1500

ccaagctgga tcagacggga gtcaccgcct tccttggcat gagtattctt cggagaattg     1560

caggtgagga agaccactat gtctttaccc tcgtgacttt tcaggaattt tttgcggcct     1620

tgttttatgt tctctgtttc ccacaaagac tcaaaaattt tcatgtgttg agccacgtga     1680

atatccagcg cctgatagcg agtcccagag gaagcaaaag ctatctctct cacatgggac     1740

ttttcttatt cggttttctg aacgaggcct gcgcttcggc cgtggaacag tcattccaat     1800

gcaaggtgtc tttcggtaat aagaggaaac tgctgaaagt catacctctg ttgcataaat     1860

gtgacccacc ttctccgggc agtggggtcc cgcagttatt ctactgtctg catgaaatcc     1920

gggaggaagc ctttgtaagc caagccctaa atgattatca taaagttgtc ttgagaattg     1980

gcaacaacaa agaagttcaa gtgtctgctt tttgcctgaa gcggtgtcaa tatttgcatg     2040

aggtggaact gaccgtcacc ctgaacttca tgaacgtgtg gaagctcagc tccagctccc     2100

atcctggctc tgaagcgcca gagagcaatg ggctgcatcg ttggtggcaa gacttatgct     2160

ctgtgtttgc aacgaatgat aagctggaag tcctgactat gaccaacagt gttttggggc     2220

ctcctttttt gaaggctctc gcggccgcac tgaggcaccc tcagtgcaaa ctgcaaaagc     2280

tactcctaag gcgtgtgaat agcaccatgt tgaaccagga cttaatcggt gttttgacgg     2340

ggaaccagca tctgagatac ttggaaatac aacatgtgga agtggagtcc aaagctgtga     2400

agcttctatg cagggtgctg agatcccccc ggtgccgtct gcagtgtctc aggttggaag     2460

actgcttggc cacccctaga atttggactg atcttggcaa taatcttcaa ggtaacgggc     2520

atctaaagac tctcatacta agaaaaaact ccctggagaa ctgtggggcg tattacctgt     2580

ctgtggccca gctggagagg ctgtcgatag agaactgcaa ccttacacag cttacttgtg     2640

aaagccttgc ctcctgtctc aggcagagta agatgctgac ccacctgagc ttggcagaaa     2700

acgccttgaa agatgaaggg gccaagcata tttggaatgc cctgccacac ctgagatgtc     2760

ctctgcagag gctggtactg agaaagtgtg acttgacctt taattgctgt caggatatga     2820

tctctgcgct ctgtaaaaat aaaaccctga aaagtcttga cctaagtttt aatagcctga     2880

aggatgatgg ggtgatcctg ctgtgtgagg ccctgaagaa ccctgactgt acattacaga     2940

tcctggagct ggaaaactgc ctgttcacct ccatctgctg ccaggccatg gcttccatgc     3000

tccgcaaaaa ccaacatctg agacatctgg acttgagcaa gaatgcgatt ggagtctatg     3060

gtattctgac cttgtgcgag gccttctcaa gccaaaagaa gagagaagag gtcattttct     3120

gtattcctgc ctggactcga ataactagct tctccccaac tcctcaccca cccgacttca     3180

cgggaaaaag tgactgccta tcccagatta atccttaggc cgtccagtca tctttctctg     3240

gggcttgatt gatcagttcc cactctgaca actggcaaat accaggcgtt atcatcctgt     3300

atgcattaac gtactttccc ctgaaacaga gcaacccagt caacaccaca gaacctcagc     3360

tttgaaccct ggagtgagga cggtgatgcc ctgtgtgtat taatatgcta tgtaaggctg     3420

ggcgtggtgg ctcacgcctg taacccagca ctatgggagg tcgaggtggg cagattacct     3480

gaggtcagga gttccagacc agcctggcca acatggtgaa accccgcctc tactaaaaaa     3540

aaaaatacaa aaaattaggc gtggtggtgg gctcctgtaa tcccagctgc tcgggaggct     3600

gaggcaggag aatcacttga atctaggagg cagagtttgc agtgagctga gatcacgcca     3660

ttgcactcca gcctgggcga cagagcaaga ctctgtctca agaagaaaaa aaaaatacat     3720

atacacataa atatatatat gtgtgtgtgt atatatatat atatatatat atatgctata     3780

taaagtttaa atgaaatgct ttgagtcacc taagacagga tatagacaaa gtcttcatcg     3840

tcttcttgct tcttctacct ttatttattc tcagctctga atgtatgaac ctgctcaatc     3900

acctcatctt aaaaataaaa tcactgtccc taga                                 3934


<210> 612
<211> 6067
<212> DNA
<213> Homo sapiens

<400> 612
cagccgcgtc ccccagcccc ggcctcccgc ggacccatgc ccgcccgtat cggctactac       60

gagatcgacc gcaccatcgg caagggcaac ttcgcggtgg tcaagcgggc cacgcacctc      120

gtcaccaagg ccaaggttgc tatcaagatc atagataaga cccagctgga tgaagaaaac      180

ttgaagaaga ttttccggga agttcaaatt atgaagatgc tttgccaccc ccatatcatc      240

aggctctacc aggttatgga gacagaacgg atgatttatc tggtgacaga atatgctagt      300

ggaggggaaa tatttgacca cctggtggcc catggtagaa tggcagaaaa ggaggcacgt      360

cggaagttca aacagatcgt cacagctgtc tatttttgtc actgtcggaa cattgttcat      420

cgtgatttaa aagctgaaaa tttacttctg gatgccaatc tgaatatcaa aatagcagat      480

tttggtttca gtaacctctt cactcctggg cagctgctga agacctggtg tggcagccct      540

ccctatgctg cacctgaact ctttgaagga aaagaatatg atgggcccaa agtggacatc      600

tggagccttg gagttgtcct ctacgtgctt gtgtgcggtg ccctgccatt tgatggaagc      660

acactgcaga atctgcgggc ccgcgtgctg agtggaaagt tccgcatccc attttttatg      720

tccacagaat gtgagcattt gatccgccat atgttggtgt tagatcccaa taagcgcctc      780

tccatggagc agatctgcaa gcacaagtgg atgaagctag gggacgccga tcccaacttt      840

gacaggttaa tagctgaatg ccaacaacta aaggaagaaa gacaggtgga ccccctgaat      900

gaggatgtcc tcttggccat ggaggacatg ggactggaca aagaacagac actgcagtca      960

ttaagatcag atgcctatga tcactatagt gcaatctaca gcctgctgtg tgatcgacat     1020

aagagacata aaaccctgcg tctcggagca cttcctagca tgccccgagc cctggccttt     1080

caagcaccag tcaatatcca ggcggagcag gcaggtactg ctatgaacat cagcgttccc     1140

caggtgcagc tgatcaaccc agagaaccaa attgtggagc cggatgggac actgaatttg     1200

gacagtgatg agggtgaaga gccttcccct gaagcattgg tgcgctattt gtcaatgagg     1260

aggcacacag tgggtgtggc tgacccacgc acggaagtta tggaagatct gcagaagctc     1320

ctacctggct ttcctggagt caacccccag gctccattcc tgcaggtggc ccctaatgtg     1380

aacttcatgc acaacctgtt gcctatgcaa aacttgcaac caaccgggca acttgagtac     1440

aaggagcagt ctctcctaca gccgcccacg ctacagctgt tgaatggaat gggccccctt     1500

ggccggaggg catcagatgg aggagccaac atccaactgc atgcccagca gctgctgaag     1560

cgcccacggg gaccctctcc gcttgtcacc atgacaccag cagtgccagc agttacccct     1620

gtggacgagg agagctcaga cggggagcca gaccaggaag ctgtgcagag ctctacctac     1680

aaggactcca acactctgca cctccctacg gagcgtttct cccctgtgcg ccggttctca     1740

gatggggctg cgagcatcca ggccttcaaa gctcacctgg aaaaaatggg caacaacagc     1800

agcatcaaac agctgcagca ggagtgtgag cagctgcaga agatgtacgg ggggcagatt     1860

gatgaaagaa ccctggagaa gacccagcag cagcatatgt tataccagca ggagcagcac     1920

catcaaattc tccagcaaca aattcaagac tctatctgtc ctcctcagcc atctccacct     1980

cttcaggctg catgtgaaaa tcagccagcc ctccttaccc atcagctcca gaggttaagg     2040

attcagcctt caagcccacc ccccaaccac cccaacaacc atctcttcag gcagcccagt     2100

aatagtcctc cccccatgag cagtgccatg atccagcctc acggggctgc atcttcttcc     2160

cagtttcaag gcttaccttc ccgcagtgca atctttcagc agcaacctga gaactgttcc     2220

tctcctccca acgtggcact aacctgcttg ggtatgcagc agcctgctca gtcacagcag     2280

gtcaccatcc aagtccaaga gcctgttgac atgctcagca acatgccagg cacagctgca     2340

ggctccagtg ggcgcggcat ctccatcagc cccagtgctg gtcagatgca gatgcagcac     2400

cgtaccaacc tgatggccac cctcagctat gggcaccgtc ccttgtccaa gcagctgagt     2460

gctgacagtg cagaggctca cagcttgaac gtgaatcggt tctcccctgc taactacgac     2520

caggcgcatt tacaccccca tctgttttcg gaccagtccc ggggttcccc cagcagctac     2580

agcccttcaa caggagtggg gttctctcca acccaagccc tgaaagtccc tccacttgac     2640

caattcccca ccttccctcc cagtgcacat cagcagccgc cacactatac cacgtcggca     2700

ctacagcagg ccctgctgtc tcccacgccg ccagactata caagacacca gcaggtaccc     2760

cacatccttc aaggactgct ttctccccgg cattcgctca ccggccactc ggacatccgg     2820

ctgcccccaa cagagtttgc acagctcatt aaaaggcagc agcaacaacg gcagcagcag     2880

cagcaacagc agcaacagca agaataccag gaactgttca ggcacatgaa ccaaggggat     2940

gcggggagtc tggctcccag ccttggggga cagagcatga cagagcgcca ggctttatct     3000

tatcaaaatg ctgactctta tcaccatcac accagccccc agcatctgct acaaatcagg     3060

gcacaagaat gtgtctcaca ggcttcctca cccaccccgc cccacgggta tgctcaccag     3120

ccggcactga tgcattcaga gagcatggag gaggactgct cgtgtgaggg ggccaaggat     3180

ggcttccaag acagtaagag ttcaagtaca ttgaccaaag gttgccatga cagccctctg     3240

ctcttgagta ccggtggacc tggggaccct gaatctttgc taggaactgt gagtcatgcc     3300

caagaattgg ggatacatcc ctatggtcat cagccaactg ctgcattcag taaaaataag     3360

gtgcccagca gagagcctgt catagggaac tgcatggata gaagttctcc aggacaagca     3420

gtggagctgc cggatcacaa tgggctcggg tacccagcac gcccctccgt ccatgagcac     3480

cacaggcccc gggccctcca gagacaccac acgatccaga acagcgacga tgcttatgta     3540

cagctggata acttgccagg aatgagtctc gtggctggga aagcacttag ctctgcccgg     3600

atgtcggatg cagttctcag tcagtcttcg ctcatgggca gccagcagtt tcaggatggg     3660

gaaaatgagg aatgtggggc aagcctggga ggtcatgagc acccagacct gagtgatggc     3720

agccagcatt taaactcctc ttgctatcca tctacgtgta ttacagacat tctgctcagc     3780

tacaagcacc ccgaagtctc cttcagcatg gagcaggcag gcgtgtaaca agaaacagag     3840

agttttgtgt acagcttggg aatgaaaagg ttgattgtaa acccacagta tctagcagcg     3900

ttgtgccaaa ttgcccttgt gtttctctcc acccaaaata tcacagctgc tttcctcaca     3960

tttggttcat ccgtgtgctg ttcttttggg ttctgagagg gttttgccat gtttgcttgt     4020

atgaccaagt caccaaggaa ataaacagga aggaaatcca tgttctccat cttttgtgaa     4080

agtatatttg agttggtggt tttttgtttt gtttgggggt ttgtgttttg ttttgttttt     4140

ggtatgtttt cttccagagg tgatatactt tctttttttt cttcctttct tttttttctt     4200

tcgttccttt tttgaaacag gagagcaaag cagttagagt tcagaggcca gcggcctcag     4260

ggccactccc tccctagcct tcatcagcag agcaccctcc atccccctgc attgctcttc     4320

tgtgaaagca aatactaaag gatgccatcc tctggaatcc taatggcagg caaagggaga     4380

gaggaagggt gacggcttct ggcacttaga aaacaaaaag aacaaaaaaa gagaaacccc     4440

caagcctgga acgcagagag gtctttactg ctgggatcca cggaaaacat gtctgtccta     4500

gccaagatca tatgaagagt ttggcacgga ggctgagaat gacctggcat agatggtttg     4560

ccagttagga tgtctcaatt tgagcctttg cttttggtgg ataactcagc tcccctcttg     4620

taacctggaa agttggttgc ctttatcatc ctgctggttt tatccatgga ctgaacaccc     4680

aacagcagtg cactatgctt tctatggcat ctttcattct cattttatat tgtgctataa     4740

aaaggattgt ttctccatat atatattata tatgtgtgta tatatataat ataatatatg     4800

tgtatatata tattatatat ataatatata atataatata ttatatatat attatatata     4860

taatatatat ataaaatata tatatatatg ctctcctctt tcagcctctt tgtcacaggg     4920

aagaagtgta ggaggttgcc ttgggccctg cctctctcct aacctcctct tccccactgg     4980

gtaccctcag cccctatatt ttaattcttg atcatgtaga aattgttttt ggtaaatgtt     5040

gatattattg ttattatcat tattaataaa taaagagaaa aggaattttt gtttaaatga     5100

gaaatgttta accagattct gttctatttg aattgtgact tgcacctttt gttcaaagta     5160

tttcctttag gcattgtaat tgtgaacagc tcttacttgt gccagtgaca gatgcagtgg     5220

tctcctttcc ccagttgaag cagtgcatac gcagtagcta ttatttgtgt tatctttatt     5280

tctcttcatt gttagaaacc aaagtcttct ctgctggctg gggctgagag agggtctggg     5340

ttatctcctt ctgatcttca aaacaagaga gagaccttga atacactgac tcttccaccc     5400

tttttttttc tgggaaagga gagcaagagg tcccgagtcc cctcctagtc tttcatcctg     5460

aatttgcaca gaggaaagcg ggtgcccggc atggccatcc tgatgttgct ggcgggatcc     5520

ccatgcacct tgtccttctc cactgatact ggcagctcgg ctcctggacc caagatccct     5580

tgagtggaat tctgcagtgc aagagccctt cgtgggagct gtcccatgtt tccatggtcc     5640

ccagtctccc ctccacttgg tggggtcacc aactactcac cagaaggggg cttaccaaga     5700

aagccctaaa aagctgttga cttatctgcg cttgttccaa ctcttatgcc cccaacctgc     5760

cctaccacca ccacgcgctc agcctgatgt gtttacatgg tactgtatgt atgggagagc     5820

agactgcacc ctccagcaac aacagatgaa agccagtgag cctactaacc gtgccatctt     5880

gcaaactaca ctttaaaaaa aactcattgc tttgtattgt agtaaccaat atgtgcagta     5940

tacgttgaat gtatatgaac atactttcct atttctgttc tttgaaaatg tcagaaatat     6000

ttttttcttt ctcattttat gttgaactaa aaaggattaa aaaaaaaatc tccagactca     6060

agttgct                                                               6067


<210> 613
<211> 5304
<212> DNA
<213> Homo sapiens

<400> 613
gcagaagtct gggcagctgc gggaggagag gtttgggagg cgcgggagat gtccaccctg       60

ggctggtggc gccgccgggc gccgggcgcc atgagggtgc gctaggcggc tgttcgtgcc      120

cgaggctgcg cagcactgag gtgagctttg ccttcttgat cttccgtcct tcttggagac      180

gactggcgag aggaagaggg actaggtcca aacgctaggt ggctgggtcc agccggagac      240

ccgcaccaag gaggagatca tcgagctctt ggtccttgag cagtacctga ccatcatccc      300

tgaaaagctc aagccttggg tgcgagcaaa aaagccggag aactgtgaga agctcgtcac      360

tctgctggag aattacaagg agatgtacca accagaagac gacaacaaca gtgacgtgac      420

cagcgacgac gacatgaccc ggaacagaag agagtcctca ccacctcact cagtccattc      480

tttcagtggt gaccgggact gggaccggag gggcagaagc agagacatgg agccacgaga      540

ccgctggtcc cacaccagga acccaagaag caggatgcct ccgcgggatc tttcccttcc      600

tgtggtggcg aaaacaagct ttgaaatgga cagagaggac gacagggact ccagggctta      660

tgagtcccga tctcaggatg ctgaatcata ccaaaatgtg gtggacctcg ctgaggacag      720

gaaacctcac aacacaatcc aggacaacat ggaaaactac aggaagctgc tctccctcgg      780

agtgcagctt gctgaagacg atggccactc ccacatgacg cagggccact catcaagatc      840

caagagaagt gcctacccaa gcaccagtcg aggtctaaaa actatgcctg aagccaaaaa      900

atcaacccac cggcggggga tttgtgaaga tgaatcttcc cacggagtga taatggaaaa      960

attcatcaag gatgtgtcac gcagttccaa atcgggaaga gcaagggagt caagcgaccg     1020

gtcacagaga ttccccagaa tgtcagatga taactggaag gacatttcat tgaacaagag     1080

ggagtcagtg atccagcagc gggtttatga agggaatgca tttaggggag gctttaggtt     1140

taattcaacc cttgtttcca gaaagagagt tcttgaaaga aagaggcgct atcattttga     1200

cacagatggg aagggctcga ttcacgatca aaaaggctgt cccaggaaga agccctttga     1260

atgtggtagt gagatgagaa aagccatgag cgtgagcagc ctgagcagcc tcagctcccc     1320

ctcctttacc gagtcacagc caattgattt tggggcaatg ccatatgtat gtgatgagtg     1380

tgggaggtcg ttcagtgtca tctcagaatt tgttgagcac cagatcatgc atactagaga     1440

gaacctctat gagtatggtg agtcctttat ccacagtgtg gctgtcagtg aagttcagaa     1500

aagtcaggtt ggagggaaac gttttgaatg taaggactgt ggagagacct tcaataagag     1560

tgccgccttg gctgaacatc ggaagattca tgctagaggt tatcttgtgg aatgtaagaa     1620

tcaggaatgt gaggaagcct tcatgcctag ccccaccttt agtgagcttc agaaaatata     1680

tggcaaagac aaattctacg agtgcagggt gtgtaaggaa accttccttc atagttctgc     1740

cctgattgag caccagaaaa tccactttgg ggatgacaaa gataatgagc gtgaacatga     1800

acgtgaacgt gaacgtgagc gcggggaaac ctttaggccc agcccagccc ttaatgagtt     1860

tcagaaaatg tatggtaaag agaaaatgta cgaatgtaag gtgtgtgggg agactttcct     1920

tcatagctca tccctgaaag aacatcagaa aatccatact agagggaacc catttgaaaa     1980

caagggtaaa gtgtgtgagg aaacctttat tcctggtcag tcccttaaaa ggcgtcagaa     2040

aacttacaat aaggagaagc tctgtgactt tacagatggc cgggatgcct tcatgcaaag     2100

ctcagagctc agtgagcatc agaaaattca ttctcgaaag aacctctttg aaggcagagg     2160

gtatgagaaa tctgtcattc atagtgggcc attcactgaa tctcagaaga gtcatactat     2220

aacaagacct cttgaaagtg atgaggacga aaaggcgttc accattagct ctaaccccta     2280

tgaaaaccag aagattccca ctaaggaaaa tgtctatgag gcaaaatcat atgagaggtc     2340

tgttattcat agcttagcct ctgtggaagc tcagaaaagt cacagtgtag cagggcccag     2400

taaaccaaaa gtaatggcag agtctaccat tcagagcttc gatgctatca accatcagag     2460

agttcgtgct ggagggaaca cctctgaagg aagggaatac agtaggtctg ttatccatag     2520

cttagtggct tccaaacctc caagaagtca caatggaaat gaattggtgg aatctaatga     2580

gaagggagaa tcctccattt atatctcaga ccttaatgat aagcgacaga agattcctgc     2640

cagagagaac ccttgtgaag ggggcagtaa gaatcgcaac tatgaagact ctgtcataca     2700

gagtgtattc cgtgccaaac ctcagaaaag tgttcctgga gagggatctg gtgagtttaa     2760

gaaggatggc gaattctctg ttcccagctc aaatgtccgt gaataccaga aggctcgtgc     2820

taaaaagaaa tacattgagc ataggagcaa tgagacctct gtaattcact ctctgccttt     2880

tggtgaacaa acatttcgcc ctcgagggat gctctatgaa tgtcaggagt gtggggagtg     2940

ctttgctcat agctctgacc tcactgagca ccagaagatt catgataggg agaagccctc     3000

tggaagcaga aactatgaat ggtctgtcat tcgcagcttg gcccctactg accctcaaac     3060

aagttacgcc caagagcagt atgctaaaga gcaagcgcgg aacaaatgta aggacttcag     3120

acaatttttt gctaccagcg aagacctcaa cacaaaccag aaaatctatg accaagagaa     3180

gtctcatggc gaggagtctc aaggcgagaa tactgatggg gaggagaccc acagcgagga     3240

gacccatggt caggagacaa ttgaagaccc tgtcattcaa ggctcagaca tggaagaccc     3300

tcagaaggat gaccctgatg acaaaatcta tgaatgtgag gactgtggcc tgggctttgt     3360

ggatctcaca gacctcacag accatcagaa agtccacagc aggaagtgcc tggttgacag     3420

tcgggagtac acacattctg taattcacac ccattccatc agcgagtatc agagagatta     3480

cactggagag cagctgtatg aatgtccaaa gtgtggggaa tcttttattc atagctcatt     3540

ccttttcgag catcagagaa tccatgaaca agaccagttg tattccatga aggggtgtga     3600

tgatggtttt attgccctct tgcccatgaa gccacggagg aatcgtgctg cagagaggaa     3660

tcctgctctt gctgggtcgg ccattcgatg ccttttgtgt ggacaaggct tcattcatag     3720

ctctgccctt aatgagcata tgagacttca tagggaagat gatttactgg agcagagcca     3780

gatggctgag gaagctatca ttccaggctt agccctcact gagtttcaga gaagtcagac     3840

cgaagagaga ctctttgaat gtgcagtctg tggagaatct ttcgtcaacc cagcagaact     3900

tgcagatcac gtaactgttc ataagaatga gccctatgag tacgggtcct cctatactca     3960

cacctcattt cttactgagc ccctcaaagg agctatacca ttctatgaat gcaaggattg     4020

tggtaagtcc tttattcata gcacagtcct cactaaacat aaggagcttc atctggaaga     4080

agaagaagaa gatgaagcag cagcagctgc agcagcagca gcccaggaag ttgaagccaa     4140

tgtccatgtt ccacaagtag ttctgaggat tcagggctta aacgtagagg ctgctgagcc     4200

agaagtggag gctgccgagc cagaagtgga ggctgctgag ccagaagtgg aggctgctga     4260

gccaaacgga gaggctgaag ggccagatgg agaggctgca gagcccattg gagaggctgg     4320

acagccaaat ggagaggccg agcagccaaa tggggatgct gatgagccag atggtgcagg     4380

tattgaagac ccagaagaaa gagctgaaga gccagaggga aaagctgaag agccagaggg     4440

agatgccgac gagcctgacg gtgtgggaat tgaagaccca gaagaaggtg aagatcaaga     4500

gattcaggta gaagaaccat actatgactg ccatgaatgc acagaaacct tcacttccag     4560

cacagcattc agtgaacacc tgaaaactca tgccagcatg atcatatttg agcctgcaaa     4620

tgcctttggg gagtgctcag gctacatcga acgtgccagc accagcacag gtggtgccaa     4680

tcaagctgat gagaagtact tcaaatgtga cgtctgtggg cagctcttca atgaccgcct     4740

gtccctcgcc agacaccaga atacccacac tggctgaggg catggggtaa aggttagaaa     4800

accttcacct aggacttgac ccttaccaaa ccacagagaa tccaaaccaa tccatgataa     4860

tgtcagtagg agacttaacc ttagtgtgtt acacacctga cttaacatct ctaaactcag     4920

attgaaaaga gaccgaatgt gcagattcca cagtcttaag ctttcccctt cagatgtcag     4980

tgtctgcatg tgggaaagcc atagcacaca tcttaccttt ccaagtaatc agattgagaa     5040

aaccctatga gtattccaga ctacagagtt tgcccaaatc aactgtaaat gacacttgtg     5100

taacgtatat atagtgtttc atgaggtgta tataaaatag caaattatga cagaacagtg     5160

atcacatata tttggattta tatgatatac agttacagtt tactctgcag aggtacctta     5220

cctggtattc tttgaatttt tttttttttt ggaggaggaa gagagcaaca aatttgatta     5280

tatttttaag tgtcttagat cctg                                            5304


<210> 614
<211> 2163
<212> DNA
<213> Homo sapiens

<400> 614
ggatcctgga ggtgggggct gtgccctgag ggagggcaca gggaaccggg atggggctgg       60

gggacagcga gtgctgggaa gtgtgcgaga tttcactccg gggctcgggt cgagctaccc      120

cgtgcttcag gcggtcctgc gcctcctctc cccaagaccc ttcggggaca cagcactgca      180

gacccgccgg agacaacttg tgcgggagcc cggagtcctc ggaataacac ttggtaagtg      240

ttaccgcgcc cttcttccct tacgccagtc cgtagttcgt ggtccttcgc cggtgtcccc      300

ggagcccagc ggctgtggat ggcagaagcc cagagtggga ctggtcagct gcaggagcag      360

aagaaaggtc ttctgatagc cgtcagcgtc tccgttgata aaatcatctc gcatttcggg      420

gccgcccgga acttggtgca gaaggcccag ttgggtgata gccggctgag cccggatgtg      480

gggcacctgg tgctgaccac cctctgcccg gccctccacg ccctggtggc ggacgggctg      540

aagcctttcc ggaaggacct catcaccggg cagcgcagga gcagcccctg gagcgtggtg      600

gaggcgtcgg tgaagccagg ctccagcacc cgctcccttg gaaccctgta tagccaggtc      660

agccgtctag ccccgctgag cagcagccgt agccgcttcc atgcctttat cctgggcctc      720

ctcaacacca agcagttgga gctgtggttt tccagtctcc aggaagatgc aggcctgctc      780

tccctcctgt acctgccaac aggatttttc tccctggccc gcggtggttg tccctccctg      840

tccacagagc tgctgctcct gctgcagcca ttgtcggtgc tcactttcca cctggacctg      900

ctctttgagc accaccacca cctgcccctg ggcccacctc aggcccctgc ccctccaggc      960

ccacctccag ctctgcagca gactatgcaa gccatgctgc actttggggg ccggctggcc     1020

cagagccttc gggggacttc caaggaagct gcttcagacc cctctgactc tccaaacctt     1080

cccacaccag ggagctggtg ggagcagttg acccaggcct cccgggtcta tgcctctggg     1140

ggcactgagg gctttcctct ttcccgatgg gcaccggggc gtcatgggac tgcagctgaa     1200

gaaggtgcac aggagagacc cctgcccaca gatgagatgg caccaggcag gggcctctgg     1260

ttgggaagac tatttggagt gcctgggggc cccgcagaaa atgagaatgg agccctaaag     1320

tccaggagac catctagctg gctgcccccg acagtgagtg tgttggctct tgtgaagcgg     1380

ggggcacctc ccgagatgcc ttctcctcag gagcttgagg cctcagcacc caggatggtg     1440

caaacccata gggcagtgcg ggctctctgt gatcacactg ctgcaagacc tgaccagttg     1500

agcttccggc gtggggaagt gctgcgtgtc atcaccacag tggatgagga ctggctccgc     1560

tgtgggcggg atggcatgga gggtctggtg cctgtggggt atacctccct tgttctgtag     1620

ccctgggacc ctttcctgcg tatgtgtctc cttcctgtca cctgggaatg gaatggccag     1680

tgaacaccat cccagaagca ttttccctct gcaaaatgac gtttcttccc acgtctgttt     1740

ctgctaatat ttaaaataaa ctttccttct tccctcctat acccacctgt aaggtgaaat     1800

ctgctcttct tccaaatata taaaaaagga attgccctcc aggtaatccc tttccttttt     1860

cccgtctata taagggaatg tcttccttcc tatctatctg caaaatggaa atctagacct     1920

ccttcttcat ccataagtgg actgtgccag tacaatacat gcctcagccc ccaagcctag     1980

aaggacctct agtctccttc ctgtgtggaa tcttccccac tccatccctc ccaagttgcc     2040

tgtattgata atgtactcac tcatgctgta ctaggtgctg aagcctggac acccttggtg     2100

ggtgggcctg tggtgatggt ttgcatcctt cctcctttgt cccaataaag tatgggagtt     2160

gaa                                                                   2163


<210> 615
<211> 4487
<212> DNA
<213> Homo sapiens

<400> 615
tggccgccgc ggctgccgct gctgctgagg cggaggccgc ggaggccgcg gaggcggagg       60

ccgaggcccc ggcgcagcgg ggcgcgcccc gggcccaggc ccggccccag ccgccgctgc      120

ggagcccgcc gggacccccc ggagcgcggc cacggcgcag ccgctgccat ggcccagaca      180

ctgcagatgg agatcccgaa cttcggcaac agcatcctgg agtgcctcaa tgaacagcgg      240

ctgcagggcc tgtactgtga cgtgtcagtg gtggtcaagg gccatgcctt caaggcccac      300

cgggccgtgc ttgctgccag cagctcctac ttccgggacc tgttcaacaa cagccgcagc      360

gccgtggtgg agctgccggc ggctgtgcag ccccagtctt tccagcagat cctcagcttc      420

tgctacacgg gccggctgag catgaacgtg ggcgaccagt tcctgctcat gtacacggct      480

ggcttcctgc agatccagga gatcatggag aagggcaccg agttcttcct caaggtgagc      540

tccccgagct gcgactccca gggcctgcat gcggaggagg ccccatcgtc ggagccccag      600

agccccgtgg cgcagacatc gggctggcca gcctgtagca ccccgctgcc cctcgtgtcg      660

cgggtgaaga cggagcagca ggagtcggac tccgtgcagt gcatgcccgt ggccaagcgg      720

ctgtgggaca gtggccagaa ggaggctggg ggcggcggca atggcagccg caagatggcc      780

aagttctcca cgccggacct ggctgccaac cggcctcacc agcccccgcc accccaacag      840

gctccggtgg tggcagcagc ccagcccgcc gtggctgcgg gagcagggca gccagccggt      900

ggggtggcag cagcaggggg tgtggtgagt gggcccagca cgtcggagcg gaccagccca      960

ggcacctcaa gcgcctacac cagcgacagc cctggctcct accacaatga ggaggacgag     1020

gaggaggatg gtggcgagga gggcatggat gagcagtacc ggcagatctg caacatgtac     1080

accatgtaca gcatgatgaa cgtcggccag acagccgaga aggtggaggc cctcccggag     1140

caggtagccc ccgagtcccg aaatcgcatc cgggttcggc aagacctggc gtctctcccg     1200

gctgaactta tcaaccagat tgggaaccgc tgccacccca agctctacga cgagggcgac     1260

ccctctgaga agctggagct ggtgacaggc accaacgtgt acatcacaag ggcgcagctg     1320

atgaactgcc acgtcagcgc aggcacgcgg cacaaggtcc tactgcggcg gctcctggcc     1380

tccttctttg accggaacac gctggccaac agctgcggca ccggcatccg ctcttctacc     1440

aacgatcccc gtcggaagcc cctggacagc cgcgtgctcc acgctgtcaa gtactactgc     1500

cagaacttcg cccccaactt caaggagagc gagatgaatg ccatcgcggc cgacatgtgc     1560

accaacgccc gccgcgtcgt gcgcaagagc tggatgccca aggtcaaggt gctcaaggct     1620

gaggatgacg cctacaccac cttcatcagt gaaacgggca agatcgagcc ggacatgatg     1680

ggtgtggagc atggcttcga gaccgccagc cacgagggcg aggcgggtcc ctcggctgaa     1740

gccctgcagt aacccgccca gcctcccgcg gggccacaca cttcccctcc caacacacac     1800

acacacctgc catcttggtc atgagctact gtctgtccct ccccaggacc cgcggtgggt     1860

gctgcatgtt cccggccctc tgcccctcct gtcctacccc ctttccccac cgagagctgg     1920

gccgggagag gaccgcaggg caggtggcgt gaggtccgtg ttgccttctt taacacacac     1980

tcgtgcagtg ggggagttct ggctccccaa cctaacccct agccgtcatc tccacactca     2040

ccaggcccac caggggaggg ggctggcctg ggggtcttgg gaaggcccct ccccaggccc     2100

taggccacct cgcggaagcc ttcagcctcc gcccctcact gcagcccctt gggacttgag     2160

gggggcccca ggggttctca ggacccctcc caccacctcc cagtgcttcc acgtctccaa     2220

aagcgccttc ctgtcaccct cgtctatccc tgcgcctggg ggctggggta ggcgaggccg     2280

tggggactac ccattttata gctggggaaa caggctccga gaaattgcac aaccgacctc     2340

aggtggccgg cagtggcgtg cctggtgccc tttctcctct tccgcctctg ttgctccctt     2400

tggtcctctg gggcctcaga gaggcaggtc ctaaaggagg gggggtctcc tgggggcaga     2460

ccgagggtct cggaggatag aatgagaggt ttccagggct ggcagagtgt gtgcgtgtgt     2520

gtgtgcagaa gttttgcttt caaacaaatg aagatacaag aggcagtagg acctgggttg     2580

gaacccaggg gagcagactg gggggctgtt gcccctccct ccatctcccc acacccaccc     2640

caccccacag cagggctcct ggcccccacc cccctgtaca taatttttaa aacctttttt     2700

tagcgaatga aatattgaag tataagattc cttttatttt tcaaaccaat ggggctgtgt     2760

ctattgtccc cctcggtccc caggggtggg gggccttgga aggcagggcg gtgttggggg     2820

gctggggggc aggctgaatg tgtgtgtgtg ggtgtgtatg tgtggagtgt gtgtgtgtgt     2880

ttccatggta ggactccagt cccagctgct gcctaggctc ctgtgggtcc tgtgggtccc     2940

cctcccctgt tcaccttccc caacagggct atagtttaag ggtgtcccag gccttggctg     3000

gttggctggg cccagctcct gggggctggg cagggcaggg cagggccggg tccacttcca     3060

ttgttagcag ttgtttgcag aattttctct tttaccattc ctctcttttt gttctcgccc     3120

agagtgggtg gttttttgtt gttgttttag attttcatgt gaaggcagtt ttttttcttt     3180

tttaactccc catcccccta tgcagggtgt catttcacca tccacatcca catccttgtt     3240

tgtgtttctg gccctcgtcc tccctgcctc tcatctgcct ccccaacccc cacctaccca     3300

ctgctcccag gggtctctcc aggggcaggg ggattttagg agatggggtg ggggccagcc     3360

cctactggac ccttgtaatc tgatttggag accatccccc cgatgggacc agcagccccg     3420

ccggcccact gggggtccct cttaacatct gcttgttgcg ggggtcagtc atgagtgcca     3480

gggtctggct ggggtcttgg cactgtcttc ctggccgggg cctgaaacct tagcccccag     3540

ccggcctgag tgggggatat tgacaccccc agctaaagca caagcacctt agtcacccct     3600

cctctccccc cgcctcctgg cctgccaccc caccccagcg tttaccccaa agcacaatgc     3660

cctggtcact tggcaagcgg ctgggcctga cggaggccga ggggcagacc ggggctccag     3720

ccagacccct gaaaggaagg tgctccccca cttccaggcc ttagttgggg tgggggggcc     3780

agctcctggg cctggggtct tctcaccccc acccccttgt cctgggtagg cccctgcctg     3840

cccctctctg ccttttcctc gggtgtccct cctcgagccc ctgtggcatt ggcttgggtg     3900

gcagagccca cttgtttcag ggaccccagg aggtgccccc tggctcccag gactgtgtgt     3960

gggtccgggg ggtggggggg tggggagaag ggtcgggcag ggggtgcagg ggaggaaact     4020

cctcaccagg agagccaaag acagggttgt gccttacccc aggagccacc cctgtacccc     4080

ccttgccctg ccattcaccc tccaccccta cccctgggcg gcctgctgct ttttccttct     4140

cttcctcccc tgccctgagc tgcatggttc ccccaccctg ggcagccagg aaggaatctg     4200

aatggagaat caccaaccac cagagaaaaa agactgtggg gccctcccct gccaactccc     4260

cttccctggc cgcccactca acccacacct ctttcacgca ggacaggctg cccaccctgt     4320

ccacgtgaag tgccaacgcc ctccccaccc tgggccgagc ccccacccct ccctgggccc     4380

ccaagtgaga ttgcacattt aactactgta aggagaggag cggcgttggc aaatgtgaac     4440

catgagaata tcagtgatac tgatgagaat aaactaaacg cctttgt                   4487


<210> 616
<211> 2044
<212> DNA
<213> Homo sapiens

<400> 616
ggtccgagtt cggaatttcg gttcaaggcc cagttcctcg gattgttcct gcgcaacttc       60

agtttccctt ccaggcacgg gcaatgagtg tttggccgcg acgagttgga aagcccggat      120

gcgtccttcg gttgggcggg gtgtctcagt gacgtcactg ggggtataaa agggcctggg      180

tggcgggcgc ctgggcagag cgtcctagca gtgtcactgc gtgggttggt ttgtgtagag      240

aggcgtgagc gagcccgttg tccggagtgc acctgctgcc tgttctgtcc ctcccgggag      300

cccccgccgc tgtcgccgtc gagtcgccat ggaagtgcag aaagaggcac agcgcatcat      360

gaccctgtcg gtgtggaaga tgtatcactc ccgcatgcag cgcggtggcc tgcggctgca      420

ccggagtctg cagctgtcgc tggtcatgcg cagcgcccgg gagctctacc tctcggccaa      480

ggtggaggcc ctcgagcccg aggtgtcgtt gccggccgcc ctcccctctg accctcgcct      540

gcacccgccc cgagaagccg agtccacggc cgagacagcg acccccgacg gtgagcaccc      600

gtttccggag ccaatggaca cgcaggaggc gccgacagcc gaggagacct ccgcctgctg      660

tgccccgcgc cccgccaaag tcagccgcaa acgacgcagc agcagcctga gcgacggcgg      720

ggacgctgga ctggtcccga gcaagaaagc ccgtctggaa gaaaaggaag aagaggaggg      780

agcgtcatcc gaagtcgccg atcgcctgca gccccctccg gcgcaagcgg agggcgcctt      840

tcccaacctg gcccgcgtcc tgcagaggcg cttctccggc ctcctgaact gcagccccgc      900

ggcccctccg acggcgccgc ccgcgtgcga ggcaaagccc gcttgccgcc cggcggacag      960

catgctcaac gtgctcgtgc gggccgtggt ggccttctga ggaccccgag cggcgctgcc     1020

ggagcccaga gcgcgcgtcg aaccgtcggc ccgagggcgc agacctgagg cgaggccacc     1080

cccctccatc ctgggggaag cgcccgcgaa aaccgtggag agaagccgcc gcccgggctg     1140

ctgagaggcc cggagaggga ctctgtcccc ggggagccat cgccttcagt gtgcagggac     1200

ggcaccgagg agtctgagcc gggggcgcgg gcgccttccg cagagacctg cgcccacagg     1260

tgctgtctta gtggactggg acgtgaacct ttcgctctcc ttctggactg ggagaaggga     1320

ggcttgggtg ttgtgttttt tgttttgttt gtttgtttgt ttttaaagat ctcctcaggg     1380

tcggacttca ttttgtactg tgggctgtgc tggccctttc aaggtttttc aagagttggt     1440

tttgcgtttc caacctcgga gaattccagg cactcccctt ccccctccgc tgacatactt     1500

gtataagcgg tcatcgttgc gtcatggggc aggcgtgggg agcttcctgt cgccttgcgt     1560

gggtgtgggg cctgggagga ggtcctgggg cgtgcacccg ccctgggcag tggggaggag     1620

agtggcctga gttacttcac ccccgcgtgc tgctggttaa tgtcccgcgt ctctgcacct     1680

tcgggtggga gcggggactg atctactttc acattctcaa gtttttctca tctgcattag     1740

aggtgcccag taggttccca ggttccagcg tgcccctccc tcagacacac ggacacaatc     1800

agccgagaag ttcctggtct gaatcacgag aatgtggagg ggtggggggt gtcagtggaa     1860

aggcataagg ctgagctgag accagttgct ggtgaaactg ggccaatctg gggaggggaa     1920

catccttgcc agggagtttc tgagggtctg ctttgtttac ctttcgtgcg gtggattctt     1980

tttaactccg tctacctggc gttttgttag aaatgtcaga taggaaaata aaaaccattt     2040

gagt                                                                  2044


<210> 617
<211> 1751
<212> DNA
<213> Homo sapiens

<400> 617
gtacactgtc tctacaggcc aggaaagagt tgtgtgtctt tggggtccct tccgctccgc       60

ctagggttcc cggccaggcc gagagaccaa gcagggacca tgcgcgtgtt ggtacccccg      120

gctgagcgca gccaggacac acgcgttggg gccccagcat ggcgcgaggc agctcaggcc      180

atggcgagga ccgcgcacat tctgaccgat cgctgcgggc aggaggcggt gaccatgtgg      240

cagcccaagg acagcgtgct ggacccgaac gtggcccacc acctcggccg cgccgcctac      300

atccagccct ggcgcttccg cgtggagatg atcaaaggcg gcggcacctt ggagaagccg      360

ccgccaggcg agggcgtcac gctgtggaag ggcaagatga agccgcccgc ctggtacgcc      420

cgcctgccgc tacccttgca ccgcaaagcg cgcgccctgc agaccaccga ggtggtgcac      480

gcgcacgcgc gtggagcgcg cctcaccgcc gcccgcctcg gccgcgcgca gcaccagatt      540

aacgggcggg tgcgacagct gctgcgccag cgcgaggtca ccgaccacag gctcagcgaa      600

gtgcgcaagg gtctgcttat taaccagcag agcgtcaagc tgcggggcta caggcccaag      660

tctgagaagg tccctgacaa agctgacagt atgcttacat gggagaaaga ggagctgaaa      720

agcatgaaga ggaaaatgga gagagatatg gaaaaatcag aggtcctact caagaccctg      780

gcctcctgcc gagacactct gaacttctgc ttcaaggagc ggctccaagc cgtggacctc      840

atgaaccagc ctctggacaa ggttctggag caggccagac gccactcatg ggtgaacctc      900

tcccgagccc ccactccacg cacacagggt cagaaaacgc ctcctccaga ccctgtgggc      960

acctataacc cagcgtgcgc cttggcgcta aacgaagcca agcggttgtt ggtcgagtcc     1020

aaggacacct tggtagaaat ggcaaagaac gaggtggacg tccgggagca acagctgcag     1080

ataagcgacc gtgtgtgtgc ctcgctggcg cagaaggcga gcgagacctt ggagctgaag     1140

gaaagattaa atatgacgtt aggactgatg aggggaacta tcctccggtg tacgaaatat     1200

aaccaagagt tgtacaccac ccacggtctc atcaagggtc ctctgtcgaa agttcacctg     1260

gagaccgcag aaaagctgga cagacccctg gttcgcatgt accagagaca cgtgggcacc     1320

caactcccgg aggctgcgcg cctcgcacag ggcaccgaca agctgcagtg ccacatcacg     1380

tacctggaaa agaacctgga cgagctgctc gccacgcaca agaacctcag ctggggcctc     1440

aactgcaaga acatcgggca tgaggtggac ggcaacgtgg tgcgcctgcg cctgcgccag     1500

cggcaaccgc acgtgtgcta cgagcaggcg cagcgcctgg ttaaggactg ggacccgcgc     1560

acgccgccgc cgcgcagcaa gagcagcgcg gacccctagt gaccccagcg tcccccgccc     1620

cagccagctg attggatgct ggctgggacc tcggagagca gacacagccc catggccctc     1680

cctctcccct gacgcaccct ccctccaagc accctctagg agaattataa ttaaaaataa     1740

caataattat c                                                          1751


<210> 618
<211> 2057
<212> DNA
<213> Homo sapiens

<400> 618
actgcagggc caggattctg gaacttgggt tgcctgatag accctataca aaagatgtag       60

tagggaaaag gagcgacagc tggctaaagg ggccccccac aaccctcccc gacaccctag      120

gaaagcagcc tctctccgct gtcccagggt gccatggaga tggagagcgc ggcggcctcc      180

acacgtttcc accagcctca catggagagg aagatgagtg cgatggcctg tgagatcttc      240

aacgagctta gactagaggg caagctctgc gacgtggtca tcaaggtcaa tggctttgag      300

ttcagtgccc ataagaacat cctctgtagc tgcagttcct actttagagc tttgtttaca      360

agtggctgga acaacactga aaagaaggta tacaacatcc ctggcatttc tcccgacatg      420

atgaagctaa tcattgagta tgcatacacc cggaccgtgc ctatcacacc ggacaatgtg      480

gagaaactgc ttgctgctgc agaccagttt aacatcatgg gtatcgtcag gggttgctgc      540

gagttcctca agtcagagct gtgcttggat aattgtatcg gcatctgtaa gttcacggac      600

tactactact gtcctgagct gaggcagaag gcctacatgt tcatactgca caactttgag      660

gagatggtga aagtctcggc agaattttta gagctctcgg tcactgaact taaggatatc      720

attgagaaag atgagctcaa tgtcaaacag gaagatgctg tatttgaggc cattttaaag      780

tggatttctc atgaccccca aaatagaaag cagcacattt caattttgct tcctaaggtt      840

cgcctggccc taatgcatgc tgagtacttc atgaacaatg ttaagatgaa tgactatgtc      900

aaagacagtg aggaatgcaa accagtcatc attaatgccc taaaggccat gtatgacctc      960

aacatgaatg gaccctctaa ttctgatttc accaacccac tcaccagacc acgcttgccc     1020

tatgccatcc tctttgcaat tggtggctgg agtggtggga gccccaccaa tgccattgag     1080

gcatatgacg ctcgggcaga cagatgggtg aatgttactt gtgaggaaga gagtccccgt     1140

gcctaccatg gggcagccta tttgaaaggc tatgtgtata tcattggggg gtttgatagt     1200

gtagactatt tcaatagtgt taagcgtttt gacccagtca agaaaacttg gcatcaggtg     1260

gccccgatgc actccagacg ttgctatgtc agtgtgacag tcctcggcaa ttttatttat     1320

gccatgggag gatttgatgg ctacgtgcgt ctaaacactg ctgaacgtta tgagccagag     1380

accaatcaat ggacactcat cgcccccatg cacgaacaga ggagtgatgc aagcgccaca     1440

acactttatg ggaaggtcta catatgtggt gggtttaatg gaaacgagtg cctgttcaca     1500

gcagaagtgt ataacactga aagtaatcag tggacagtca tagcacccat gagaagcagg     1560

aggagtggaa taggcgtgat tgcttatgga gaacatgtat atgcggtagg tggctttgat     1620

ggagctaatc gacttaggag tgccgaagcc tacagccctg tggctaacac ttggcgcaca     1680

atccccacta tgtttaatcc tcgtagcaat tttggcatcg aggtggtgga tgacctcttg     1740

tttgtggtgg gtggctttaa tggttttacc accaccttta atgttgagtg ctatgatgaa     1800

aagaccgatg agtggtatga tgctcatgac atgagtatat accgcagtgc tctgagctgc     1860

tgtgtagtac cagggctggc caatgttgag gaatatgcag ctagacggga caacttccca     1920

ggattagcac tgcgagatga agtaaaatat tctgcttcga caagtaccct acctgtatga     1980

gcctcttcat ttagctaata aaaagtctaa gcaataagaa ttaattcttt ttttaaaaaa     2040

atgcagtgtt taaactt                                                    2057


<210> 619
<211> 1765
<212> DNA
<213> Homo sapiens

<400> 619
agatttgttg caagctgtgg gaggaaggag agttcttctt ccaggtggtt tcctgcagac       60

tgcctgctag ggctcagagg accagcttct tccctgctgt ctcctgagcc cagtccctct      120

tggccatcac attccccttg ccctatggcg gccctcacag acctctcatt tatgtatcgc      180

tggttcaaga actgcaatct ggttggcaac ctctcagaga agtacgtctt catcacaggc      240

tgtgactctg gcttcgggaa cctgctggcc aaacagctgg ttgatcgggg catgcaggtg      300

ctggctgctt gcttcactga ggagggatcc cagaaacttc agcgggatac ctcctatcgg      360

ctgcagacca ccctactgga tgtcaccaag agcgaaagca tcaaggcggc ggcccagtgg      420

gtgagggaca aagtgggcga acaaggcctc tgggccctgg tgaacaatgc tggtgtgggc      480

ctgcccagtg gtcccaacga atggctgacc aaggatgact ttgtgaaggt gattaatgtg      540

aacctggtgg gactgatcga agtgaccctt cacatgctgc ccatggtcaa gagagcccgg      600

ggcagggttg tcaacatgtc cagctctggt ggtcgtgtgg ctgtcattgg tggtggctac      660

tgcgtctcca agtttggcgt tgaggccttc tctgacagca taaggcgtga gctctactac      720

tttggggtga aagtctgcat cattgagcca gggaactatc ggacagccat tctcggcaag      780

gagaacctgg agtcacgcat gcgaaagctt tgggagaggc tgcctcagga gacccgggac      840

agctacggag aggattattt ccgcatctat actgacaagt taaaaaacat aatgcaggtg      900

gcagagccca gagtcagaga tgtcatcaac agcatggagc atgctattgt ttcccggagc      960

cctcgcatcc gctacaaccc tggcctggat gccaaactcc tctacatccc tctggctaag     1020

ttgcccaccc ctgtgacaga tttcatccta agccggtacc ttccaaggcc agcggacagt     1080

gtctaaactg gggaggatca atgggtcagt ggagcctaga agtgggggag gaaggaagga     1140

ccgtggggtc acaaaaggtg gtatcggtta tcctgggggc attggctgca aaggaagctt     1200

ggctcagctg acacccactg ctgtcgaatt taccagtaac ttctaacaga aggtgaatgc     1260

ctcttcccac cctctgggac cccacagaaa cctgaggtgg tctttgcagg ttcagcgatc     1320

tgcagcaata gctccaagga cgtctgtcac ccaatcagga tacagctttt tctggtcctg     1380

gaaaagtcat ggagaagaaa accagctcct gtggaatcat gagccccttt cagttatcac     1440

tgccactgag aaatactgtg ggataatctt gcctccagga gaatctaacc accttcctaa     1500

tgggtccctc aatatgcata acttcattca cataacccat tactgaagta tgcggtaggg     1560

cagataggga gtgcaagatt aaatcagaca aaagtttaaa atattttctt tctttttaga     1620

ttcttctatc tataggttat tgggatccac atgaaataac attcatttat ttaatcacca     1680

ttaatttttc aaatatttat tgagtgccta ctacctaccg ggcactttgt aggtgctggg     1740

ggaatataaa gatgattaaa tcatg                                           1765


<210> 620
<211> 2091
<212> DNA
<213> Homo sapiens

<400> 620
tccattcgga cgtctccatc ctcagaacct cctctcttcc ccaaaaagca ccatgacttg       60

tggatcttac tgtggtggcc gcgccttcag ctgcatctcg gcctgcgggc cccggcccgg      120

ccgctgctgc atcaccgccg ccccctaccg tggcatctcc tgctaccgcg gcctcaccgg      180

gggcttcggc agccacagcg tgtgcggagg ctttcgggcc ggctcctgcg gacgcagctt      240

cggctaccgc tccgggggcg tgtgcgggcc cagtccccca tgcatcacca ccgtgtcggt      300

caacgagagc ctcctcacgc ccctcaacct ggagatcgac cccaacgcgc agtgcgtgaa      360

gcaggaggag aaggagcaga tcaagtccct caacagcagg ttcgcggcct tcatcgacaa      420

ggtgcgcttc ctggagcagc agaacaaact gctggagaca aagctgcagt tctaccagaa      480

ccgcgagtgt tgccagagca acctggagcc cctgtttgag ggctacatcg agactctgcg      540

gcgggaggcc gagtgcgtgg aggccgacag cgggaggctg gcctcagagc ttaaccacgt      600

gcaggaggtg ctggagggct acaagaagaa gtatgaggag gaggtttctc tgagagcaac      660

agctgagaac gagtttgtgg ctctgaagaa ggatgtggac tgcgcctacc tccgcaaatc      720

agacctggag gccaatgtgg aggccctgat ccaggagatc gacttcctga ggcggctgta      780

tgaggaggag atccgcgttc tccagtccca catctcagac acctccgtgg ttgtcaagct      840

ggacaacagc cgggacctga acatggactg catcattgcc gagatcaagg cacagtacga      900

tgacattgtc acccgtagcc gggctgaggc cgagtcctgg taccgcagca agtgtgagga      960

gatgaaggcc acggtgatca ggcacgggga gaccctgcgc cgcaccaagg aggagatcaa     1020

cgagctgaac cgcatgatcc agaggctgac ggctgaggtg gagaatgcca agtgccagaa     1080

ttccaagctg gaggctgcgg tggctcagtc tgagcagcag ggtgaggcgg ccctcagcga     1140

tgcccgctgc aagttggccg agctggaggg tgccctgcag aaggccaagc aggacatggc     1200

ctgcctgatc agggagtacc aggaggtgat gaactccaag ctgggcctgg acatcgagat     1260

cgccacctac aggcgcctgc tggagggcga ggagcagagg ctgtgcgagg gcgtcggctc     1320

ggtgaatgtc tgcgtcagca gctcccgcgg tggcgttgtc tgtggcgatc tctgcgcctc     1380

cactactgcc cctgttgtct ccaccagagt cagtagcgtc cccagcaaca gcaacgtggt     1440

ggtgggcact actaacgcct gcgccccctc cgcccgggtt ggcgtctgcg gcggcagctg     1500

taagaggtgc taggaggctg ccgcctccgc cagcgcctgt cgccgtcact ctccacccag     1560

ccagtacctc gcgccaccag aacgcgccgc ccgcgccggc ctcccaatag ccgccgcccg     1620

ctgcctgcac tctaagcgcc ctccccaccg ctccgctccg ggagccatcc ccggtcgcag     1680

gagtccgggg agggccggga ggcgccatgg tctctctctg tagcctttcc tggtagtcaa     1740

tttgttgtcc cgaggattca tctttttctt ccgcctgcct tctgtttttt ttgctgtata     1800

cattggtctt gcctgagctc ttccccaaag cttggaggaa cgggggaggc ccgggaatgt     1860

ccctgtctgc acgacctggg actctgccca tgtgcttttg cctgtggaat ggagacgcgg     1920

accctggata gtggttctat gactctgcga gggacaggcc cacgcgtgtg gggagaacat     1980

ctcccttccg gggctgccct caagagcttc tgaaaaacta atgactctgc tgccttctcc     2040

tttgtctttg tttcactctg tgtttccaat aaactcattg tagcgaatca a              2091


<210> 621
<211> 1291
<212> DNA
<213> Homo sapiens

<400> 621
ggctgctata gagccgggtg agagagcgag cgcccgtcgg cgggtgtcga gggcgggttg       60

cctcgcgctg acccttcccg ccctccttct cgtcacacac caggtccccg cggaagccgc      120

ggtgtcggcg ccatggcgga gctgacggct cttgagagtc tcatcgagat gggcttcccc      180

aggggacgcg cggagaaggc tctggccctc acagggaacc agggcatcga ggctgcgatg      240

gactggctga tggagcacga agacgacccc gatgtggacg agcctttaga gactcccctt      300

ggacatatcc tgggacggga gcccacttcc tcagagcaag gcggccttga aggatctggt      360

tctgctgccg gagaaggcaa acccgctttg agtgaagagg aaagacagga acaaactaag      420

aggatgttgg agctggtggc ccagaagcag cgggagcgtg aagaaagaga ggaacgggag      480

gcattggaac gggaacggca gcgcaggaga caagggcaag agttgtcagc agcacgacag      540

cggctacagg aagatgagat gcgccgggct gctgaggaga ggcggaggga aaaggccgag      600

gagttagcag ccagacaaag agttagagaa aagatcgaga gggacaaagc agagagagcc      660

aagaagtatg gtggcagtgt gggctctcag ccacccccag tggcaccaga gccaggtcct      720

gttccctctt ctcccagcca ggagcctccc accaagcggg agtatgacca gtgtcgcata      780

caggtcaggc tgccagatgg gacctcactg acccagacgt tccgggcccg ggaacagctg      840

gcagctgtga ggctctatgt ggagctccac cgtggggagg aactaggtgg gggccaggac      900

cctgtgcaat tgctcagtgg cttccccaga cgggccttct cagaagctga catggagcgg      960

cctctgcagg agctgggtat ggctgcaaga ctagaaacca ggactagaaa ctgggggagt     1020

agggaggcat gcctaggaaa aggagggatg caaagagaag gggctttgtg aacatggtgc     1080

aaggccagga attttgggag caaaaaccaa gtatccttgt ggttcaagcc tgttttcttc     1140

catcttcagg actcgtgcct tctgctgttc tcattgtggc caagaaatgt cccagctgag     1200

ggcctttgtc ccattgtccc tctgtgaccc cttcatcttt gataaagcac tgacatctcc     1260

ttcctaataa atagaccctg agttctgtac a                                    1291


<210> 622
<211> 636
<212> DNA
<213> Homo sapiens

<400> 622
gagcctccgg ccgcccgccg ggtttgtccc gcgatccccg accatgcccg ccgacctcag       60

cggtacttgg accctgctca gcagcgacaa cttcgagggc tacatgctgg ccctaggtat      120

tgactttgcc actcgtaaaa tagccaagtt gctgaagcca cagaaagtga ttgagcagaa      180

tggggattct tttaccatcc acacgaacag cagcctaagg aactactttg tgaaatttaa      240

agttggagaa gaatttgatg aagataacag aggcctggac aacagaaaat gcaagagttt      300

ggttatctgg gacaatgaca ggctcacctg tatccagaag ggagaaaaga agaacagagg      360

ctggacccat tggatcgaag gagacaaact ccacctggaa atgttctgtg aaggtcaagt      420

gtgcaaacag acattccaga gagcctgatc cacatccagc agcagagccc acttgtggct      480

gcagctttat gccaaattat attgcagact gaacagacgt ttatctatcc catttggcga      540

cgaggactcg tggctggaga gagccacaca gcgtgtaacc tgaagtcatc tagattatgg      600

ggaaactgct cagcttcaat aaacctgtcc aaatga                                636


<210> 623
<211> 2182
<212> DNA
<213> Homo sapiens

<400> 623
tgggcggggt tatataagcc agcggcgggc ggaaggcggg gcgtgggggt ctgtggctgc       60

tgggctggcg gggcgcaggc cgcgggaccc gagcccgggg aagcgagaga gcggaggcgc      120

cgaggatccg attcactccc tggggagacc tatgggccga agccgtgtaa atgcgtttta      180

agcagaggcc tcggctccgc aactgccact cctcctcggg gtgttgcaca agtttcgagg      240

tcaccggcga ccccccctag cagcgcgcct ggctctggcc cccgcgaagg aggacggagt      300

ttggagcttg cggcccccac ccaccgcgtg gcgtccccag gcacgcctag aattctagca      360

cctcaggatc agtccagccc ccatttacaa ttggggaaac tgcggctccg aaagggtcag      420

agggtacccg aggtcaagca gtagagagcg gactcgaact taagctcttg ctcttaggct      480

gagacgcctt gatgtggcca ccggctaccc tctagtgtgt tgcatacttt ctaaggcggc      540

ggctgcagca gcggctccat ccagcccgtc agctcctcct gcaaggcatg gctggctacc      600

tgagtgaatc ggactttgtg atggtggagg agggcttcag tacccgagac ctgctgaagg      660

aactcactct gggggcctca caggccacca cggacgaggt agctgccttc ttcgtggctg      720

acctgggtgc catagtgagg aagcactttt gctttctgaa gtgcctgcca cgagtccggc      780

ccttttatgc tgtcaagtgc aacagcagcc caggtgtgct gaaggttctg gcccagctgg      840

ggctgggctt tagctgtgcc aacaaggcag agatggagtt ggtccagcat attggaatcc      900

ctgccagtaa gatcatctgc gccaacccct gtaagcaaat tgcacagatc aaatatgctg      960

ccaagcatgg gatccagctg ctgagctttg acaatgagat ggagctggca aaggtggtaa     1020

agagccaccc cagtgccaag atggttctgt gcattgctac cgatgactcc cactccctga     1080

gctgcctgag cctaaagttt ggagtgtcac tgaaatcctg cagacacctg cttgaaaatg     1140

cgaagaagca ccatgtggag gtggtgggtg tgagttttca cattggcagt ggctgtcctg     1200

accctcaggc ctatgctcag tccatcgcag acgcccggct cgtgtttgaa atgggcaccg     1260

agctgggtca caagatgcac gttctggacc ttggtggtgg cttccctggc acagaagggg     1320

ccaaagtgag atttgaagag attgcttccg tgatcaactc agccttggac ctgtacttcc     1380

cagagggctg tggcgtggac atctttgctg agctggggcg ctactacgtg acctcggcct     1440

tcactgtggc agtcagcatc attgccaaga aggaggttct gctagaccag cctggcaggg     1500

aggaggaaaa tggttccacc tccaagacca tcgtgtacca ccttgatgag ggcgtgtatg     1560

ggatcttcaa ctcagtcctg tttgacaaca tctgccctac ccccatcctg cagaagaaac     1620

catccacgga gcagcccctg tacagcagca gcctgtgggg cccggcggtt gatggctgtg     1680

attgcgtggc tgagggcctg tggctgccgc aactacacgt aggggactgg ctggtctttg     1740

acaacatggg cgcctacact gtgggcatgg gttccccctt ttgggggacc caggcctgcc     1800

acatcaccta tgccatgtcc cgggtggcct gggaagcgct gcgaaggcag ctgatggctg     1860

cagaacagga ggatgacgtg gagggtgtgt gcaagcctct gtcctgcggc tgggagatca     1920

cagacaccct gtgcgtgggc cctgtcttca ccccagcgag catcatgtga gtgggcctcg     1980

ttccccccgg agaatcccag cggggcctca gagatgcatc tgggagaggt ggggaagatg     2040

gcaggcaagg gtacccttgg ccaggactct ggtgcccacc ctgccacccc cgcgctccac     2100

ctgcagtgtt tctgccctgt aaataggacc agtcttacac tcgctgtagt tcaagtatgc     2160

aacataaatc ctgttccttc ca                                              2182


<210> 624
<211> 1472
<212> DNA
<213> Homo sapiens

<400> 624
ccgcaggcgg gcctcgcggg tccgggagcg cggcggagac gatgcctgag atcagagtca       60

cgcccttggg ggccggccag gacgtgggcc gaagctgcat cctggtctcc attgcgggca      120

agaatgtcat gctggactgt ggaatgcaca tgggcttcaa tgacgaccga cgcttccctg      180

acttctccta catcacccag aacggccgcc taacagactt cctggactgt gtgatcatta      240

gccacttcca cctggaccac tgcggggcac tcccctactt cagcgagatg gtgggctacg      300

acgggcccat ctacatgact caccccaccc aggccatctg ccccatcttg ctggaggact      360

accgcaagat cgccgtagac aagaagggcg aggccaactt cttcacctcc cagatgatca      420

aagactgcat gaacctcctg gagaccttct gggagcgcat gaacctgaag gtgcccatct      480

acttctccac ggggctgacc gagaaggcca accactacta caagctgttc atcccctgga      540

ccaaccagaa gatccgcaag actttcgtgc agaggaacat gtttgagttc aagcacatca      600

aggccttcga ccgggctttt gctgacaacc caggaccgat ggttgtgttt gccacgccag      660

gaatgctgca cgctgggcag tccctgcaga tcttccggaa atgggccgga aacgaaaaga      720

acatggtcat catgcccggc tactgcgtgc agggcaccgt cggccacaag atcctcagcg      780

ggcagcggaa gctcgagatg gaggggcggc aggtgctgga ggtcaagatg caggtggagt      840

acatgtcatt cagcgcacac gcggacgcca agggcatcat gcagctggtg tcctcagagc      900

aagccctcaa agagctgggt ctggctgagc accagctgcg cttcacctgc cgcgtgcacc      960

tgcatgacac acgcaaggag caggagacgg cattgcgcgt ctacagccac ctcaagagcg     1020

tcctgaagga ccactgtgtg cagcacctcc cagacggctc tgtgactgtg gagtccgtcc     1080

tcctccaggc cgccgcccct tctgaggacc caggcaccaa ggtgctgctg gtctcctgga     1140

cctaccagga cgaggagctg gggagcttcc tcacatctct gctgaagaag ggcctccccc     1200

aggcccccag ctgaggccgg caactcaccc agccgccacc tctgccctct cccagctgga     1260

cagaccctgg gcctgcactt caggactgtg ggtgccctgg gtgaacagac cctgcaggtc     1320

ccatccctgg ggacagaggc cttgtgtcac ctgcctgccc aggcagctgt ttgcagctga     1380

agaaacaaac tggtctccag gctgtcttgc ctttattcct ggttagggca ggtggtccta     1440

gacagcagtt tccagtaaaa gctgaacaaa ag                                   1472


<210> 625
<211> 4267
<212> DNA
<213> Homo sapiens

<400> 625
tgagcgggca ctcttctgcg gcaagcaggt ctaggaattc gcctggttcc cacctcgcgt       60

cccttgcctt ccttcctagt ctacccactg tagtgccccc tgcgtcccgc tccctcctag      120

ccgactcaga gcacaagaag gattgccacg gtttccattg cagcagccgt ggcgcctctg      180

accctttttt tatatcgcgg cgacggcggg ctgtcgtcac gacgacgtgc ggacgcagcg      240

gcgggggcct ttcagcttat gtggagaagt cgctgtgaag ccacctataa atccatttac      300

tgaatttatg gagaaggctg taaatgatgg aagtcattca gaagaactct tttgccatct      360

taaaactata tcagagaaag aagatttacc acggtgtacc agtgaaagtc atctcagctg      420

cctgaagcag gacattctaa atgaaaagac tgaattggaa gcaacactta aggaagcgga      480

gttggtaact cattctgtag aattgctttt gccactattt aaggacacca ttgaaaagat      540

taattttgaa aatgcgaatc tttctgcatt gaatttgaag atttctgaac agaaggaaat      600

attaataaaa gaattagaca ccttcaaaag tgtaaaacta gctttagaac atcttcttag      660

aaagagagac tacaaacaaa caggagacaa tttatccagc atgttgctag aaaatctaac      720

tgataatgaa agtgaaaata ctaatcttaa gaagaaggta tttgaaaagg aggcccatat      780

ccaagaactt tcttgtttgt ttcagagtga aaaggcaaat actttgaaag caaaccgttt      840

ttcccaatca gtaaaagtag tacatgaacg actacagatc caaattcata aaagggaagc      900

cgagaacgat aagttgaaag aatatgtaaa gagcttagaa accaagatag ccaagtggaa      960

cctgcaatca agaatgaata agaatgaggc tatagtgatg aaagaagcaa gtaggcaaaa     1020

aactgtagct ttaaaaaagg catctaaagt ttacaaacaa aggcttgacc attttacagg     1080

agctattgaa aagcttactt cccaaattag agatcaggaa gccaagttgt ctgaaacaat     1140

ttcagcttcc aatgcctgga aaagtcatta tgagaaaatt gtgatagaaa aaaccgaatt     1200

ggaagtacag attgaaacaa tgaaaaagca aatcattaat cttttggaag atctgaagaa     1260

aatggaagac catggaaaaa attcatgtga agaaattctt agaaaagttc actcaattga     1320

atatgaaaat gaaactctga atcttgagaa tacaaaatta aagactacac ttgctgcttt     1380

gaaggatgaa gttgtatctg ttgaaaatga actctcagaa ttgcaagaag tagaaaaaaa     1440

acagaaaacc cttattgaaa tgtataaaac tcaggtacaa aagttgcaag aagcagctga     1500

aatagtaaaa agcagatgtg aaaatttgct acataaaaat aaccaaataa caaaaaccaa     1560

aaataaaaat gtagagaaga tgagaggcca gatggagtct catctgaagg agttagagcg     1620

tgtctgcgat tccttgacgg cggcggaacg gaggcttcac gagtgtcagg agagtctgca     1680

gtgctgcaag gggaagtgtg cagaccagga acacaccatt agggagcttc agggccagat     1740

tttgaagcag tgggaagaat attctgtctt ggcatgggtt gatggaaatc acaatcttct     1800

gacaaagctt tctctggaag aggaaaactg tcttattcag ctgaagtgtg aaaaccttca     1860

acaaaaatta gaacagatgg acgcagaaaa taaagagctt gagaagaagc tggcaaacca     1920

agaagaatgt cttaagcaca gcaatcttaa gtttaaagag aaatctgcag agtatacagc     1980

attggccaga caactggaag ctgctttaga agaaggaaga caaaaggttg ctgaagaaat     2040

agagaaaatg tcatctagag agagtgcttt acaaattaaa atattagatc tggaaactga     2100

gcttagaaag aaaaatgaag aacaaaatca acttgtttgc aaaatgaaca gtgatccaga     2160

gactccatga aatctatttt tttaattccc aagtgtctaa aaagttgaaa acctaaaaga     2220

ttcaagagtt aaatgatttt tggcatgcac aatttgattt tattgccatc aaaagtttca     2280

tgacaactta gtcagaacaa aacgtcgatc acctttaatt tagcacaggc cttccattta     2340

tttctaaact tttttttaac tcaccatttg actttctgat attgtaaaat gtgtgtgctg     2400

tttttttgtg taattgaagc ctctgaaaaa ataaatgagg tgggttttgc tgtaatgtcc     2460

ctagtacttg gctaaagcta gtaaaataaa tagatcccat tcacaattgc cacaaagaga     2520

ataaaatacc taggaatcca aattacaagg aatgtgaagg acctcttcaa ggagaactac     2580

aaaccactgc ttaaggaaat aagagaggac acaaacaaat ggaaaacatt ccatgcttat     2640

gaataagatg aaacaagatc atgaaaatgg ctatactccc caaagtaatt tatagattca     2700

gtgctatccc catcaagcta ccattgactt tcttcacaga attagaaaaa actacttcaa     2760

atttcatatg gaaccaaaaa agagctcaca taaccaagac aatcctaagc aaaaagaaca     2820

aagctgtagg catcacgcta cctgacttca aactatacta caaggctaca gtaaccaaaa     2880

tagcatggta ctggtgccaa aacagatata tagaccaatg gaacagaaca gaggcctcag     2940

aaataactcc acacatctac aaccatctgc tgtttgacat acctgagaaa aacaagaaat     3000

ggggaaagga ttccctattt aataaatggt gttgggaaaa ctggctagcc atatgcagaa     3060

aactgaaact ggatcccttc cttacacctt atacaaaaat taactcaaga tggattaaag     3120

acttaagtgt aagacctaaa accataaaaa ccctagagga aaacctaggc aataccattc     3180

aggacatagg catggacgaa tacttcatga ctaaaacacc aaaagtaatg gcaataaaag     3240

ccaagattga caaatgggat ctaattaaac taaagagctt ctgcacagca aaagaaacta     3300

tcatcagagt gaacaggaac cgacagaatg ggagaaaatt tttgcaatct atccatctga     3360

caaagggcca atatccagaa tctacaaaga acttaaacaa atttacaaga aaaaaaaccc     3420

catcaaaaag tgtgcaaaga atatgaacag acacttctca agagaagaca tttagtcagc     3480

caaaaaacat atgaaaaaaa gctcatcact ggtcattcag agaaatgcaa atcaaaacta     3540

cagtgagata ccatgtcaca ccaattagaa tggtgatcat taaaaagaca ggaaacaaca     3600

gatgctggag aggatgtgga gaaataggat gcttttacac tgttggtggg agtgtaaatt     3660

agttcaacca ctgcggaaga cagtgtggcg attcctcaag gatctagaac cagaaatacc     3720

atttgaccca gcaatcccat tactgggtat atacccaaag gactataaat catgctgcta     3780

tagagacaca tgcacacgta tatttattgt ggcactattc acaatagcaa agacttggag     3840

ccaacccaaa tgcccatcaa tgatagactg aataaagaaa atgtggcaca tacaccatgg     3900

aatactatgc agccataaaa aaggatgagt tcatgtcctt tgcagggaca tggatgaagc     3960

tggaaaccat cattctcagc aaactaacac aagaacagaa aaccaaacac cgcatgttct     4020

cactcataag tgggagttga acaatgagaa tacatggata cagggcaggg aacatcacac     4080

accagggcct gtcagggcgt ggggggctag gggagggata acattagaaa ttcctaatgt     4140

agatgacggg ttgatgagtg cagcaaacca ccatggcacg tgtataccta tgtaaccaac     4200

ctgtacgttc tgtacatgta tcccagaact taaagtataa taaaaattaa aaaaaataaa     4260

gatctga                                                               4267


<210> 626
<211> 1637
<212> DNA
<213> Homo sapiens

<400> 626
gggaagtgaa tcaggcgccg ggtagtgggt tgctgggctg ggcttgctga ggtagaggca       60

gcgccaagaa gaggcctttg ccgctggtcg ggattgggat gtcgaagaac acagtgtcgt      120

cggcccgctt ccggaaggtg gacgtggatg aatatgacga gaacaagttc gtggacgaag      180

aagatggggg cgacggccag gccgggcccg acgagggcga ggtggactcc tgcctgcggc      240

attccatcac aggaaacatg acagctgccc tacaggcagc tctgaagaac ccccctatca      300

acaccaagag tcaggcagtg aaggaccggg caggcagcat tgtcttgaag gtgctcatct      360

cttttaaagc taatgatata gaaaaggcag ttcaatctct ggacaagaat ggtgtggatc      420

tcctaatgaa gtatatttat aaaggatttg agagcccgtc tgacaatagc agtgctatgt      480

tactgcaatg gcatgaaaag gcacttgctg ctggaggagt agggtccatt gttcgtgtct      540

tgactgcaag aaaaactgtg tagtctggca ggaagtggat tatctgcctc gggagtggga      600

attgctggta caaagaccaa aacaaccaaa tgccaccgct gccctgtggg tagcatctgt      660

ttctctcagc tttgccttct tgctttttca tatctgtaaa gaaaaaaatt acatatcagt      720

tgtcctttaa tgaaaattgg gataatatag aagaaattgt gttaaaatag aagtgtttca      780

tcctttcaaa accatttcag tgatgtttat accaatctgt atatagtata atttacattc      840

aagtttaatt gtgcaacttt taacccctgt tggctggttt tttgttctgt tttgttttgt      900

attattttta actaatactg agagatttgg tcagaatttg aggccagttt cctagctcat      960

tgctagtcag gaaatgatat ttataaaaaa tatgagagac tggcagctat taacattgca     1020

aaactggacc atatttccct tatttaataa gcaaaatatg tttttggaat aagtggtggg     1080

tgaataccac tgctaagtta tagctttgtt tttgcttgcc tcctgattat ctgtactgtg     1140

ggtttaagta tgctactttc tctcagcatc caataatcat ggcccctcaa tttatttgtg     1200

gtcacccagg gttcagagca agaagtcttg ctttatacaa atgtatccat aaaatatcag     1260

agcttgttgg gcatgaacat caaacttttg ttccactaat atggctctgt ttggaaaaaa     1320

ctgcaaatca gaaagaatga tttgcagaaa gaaagaaaaa ctatggtgta atttaaactc     1380

tgggcagcct ctgaatgaaa tgctactttc tttagaaata taatagctgc cttagacatt     1440

atgaggtata caactagtat ttaagatacc atttaatatg ccccgtaaat gtcttcagtg     1500

ttcttcaggg tagttgggat ctcaaaagat ttggttcaga tccaaacaaa tacacattct     1560

gtgttttagc tcagtgtttt ctaaaaaaag aaactgccac acagcaaaaa attgtttact     1620

ttgttggaca aaccaaa                                                    1637


<210> 627
<211> 3525
<212> DNA
<213> Homo sapiens

<400> 627
aatctctact cggcccgcac cagcagcgct ggcgtcaggg cgcggtgggg gcaagacggg       60

tgactggcag cagggcggtg ccgggccgag aagggcgcct cacctggcgc ctcctgcctt      120

cctttccacc tcaggttgca gagagccgcc agggcaggtg gaagggccac gccccgctcc      180

cgtgagggtc accgagagac gttgggggtg gggcagggac cccaacccta gaccagtcct      240

gtagggcaca atgtctgaac aagagcgtat acaggaatgt ctgcggaagg aaataaggtc      300

acttctcatt tccaccaaag atggtttgag cccacaggag ttggagaagg agtacctttt      360

gatggttggc aaccatctac cactccgaat ccttgggtat cggtccacta tggagctggt      420

attggacatg cctgatgttg ttcgtgtctg ccccggtgca ggtggtactg taatactgaa      480

agccattcca gatgaatcta ccaaaggaat agcaagctta gttgcaaaac agaggagcag      540

ccataagctt cgaaactcaa tgcataaggg aagacctagt atttattctg gaccgagatc      600

tcatcggcga gtaccttacc gaggaagggt tgcccctatt cttccagctg ttgtgaagag      660

tgagttgaag gacctgttgg cgttatctcc tgttcttctt tctgattttg aaaaggcatt      720

tgccaaaaga tttggacgat cattccaata catgcaatat ggatttctct ctatgtttga      780

agtgcttaat gcggcttcag atgtcatttc tgtagagcag accagagcag gttctttgtt      840

gatgctaaag aagagtgtaa cagaggaaaa gccgagagga tgtccagcag gtaaaatttt      900

tacccagcca tttagaatga aacaagggtc atactccaca ggctttccgg tagcaaagcc      960

atgcttttca caacccactt caaacatgga accaccgaag caaataatga gcatggaaaa     1020

gacttccaag ttaaatgtag tggagacttc aagactgaat cacactgaaa aattaaacca     1080

gctggagaac acattcaaat cagttattgc acagattgga cctggaggaa ctatcagttc     1140

agaactaaaa cataagataa aatttgttgt atctaagttc ccagagggtt tgtttatttc     1200

taaactgctt ggagagtatg aggtaatttt taaagagcaa ctatcaccaa aaaaattagg     1260

cttcttaaat gtgacagaac ttgttggagc tcttagtgac attctccatg ttgagttcag     1320

gaaaggacac caagacttac tagtgtttga tgcggataag aagcctctac cacctgttca     1380

gtcagataag aaaatagaag ccaaagcttg tgtctccagt ccacctagaa attcattgtc     1440

tactgctgct gtcaaagaga ctgtatggaa ttgcccttca aaaaaacaaa aagagccaca     1500

acagaagatt tgcaagaagc ctaatctggt ggtaaagcct ttacagctgc aagtagaaac     1560

aaacaaatca gagctcaact tggcaatggc aaatcatgac atcccgccag acgctgtgcc     1620

gaacaagaaa ttatgcagac tcccaccatt agacaccagt tccctcatag gggtctttgt     1680

ggagtatatc atctctccta gtcaattcta catccggatc tatagcaggg attcgtcaga     1740

gttactcgaa gacatgatga ttgaaatgcg gcgctgttat tctaatcagc tggtttctga     1800

tcgatatgtc atgccagaat gttttattca gccgggacat ctctgttgtg taaggatttc     1860

tgaggataag tggtggtatc gggtcattat ccatcgagtc cttgagaaac aggaagttga     1920

agtgttctac ccagactttg gaaatattgg aattgttcag aagtcctccc tgaggttcct     1980

caagtgctgc tacacaaagc ttccagctca ggctatccct tgttctttgg cttgggtgag     2040

accagtagag gaacactgga catcgaaagc tattttgcag ttccagaagt tgtgcggttt     2100

gaagccatta gtgggggtag tggatgaata tgtagatgga atccttaaca tttttttgtg     2160

tgacacatcc tcaaacgaag atgtctattt ccatcatgtc ttgagaacag agggccatgc     2220

tattgtatgc cgagaaaata tctcttctaa gggtttcagt gagctcaacc ctttagcttt     2280

atacacgaca tccagtggag ggccagagga cattgtcttg acagaactgg gttatccttc     2340

ccagcagcac tattttaatg aagaccgaaa gataagtcca cagtcaaaag agagtgagtt     2400

acgtatcttg gatgagatcc ccactggaat gccatgcctg gagtcagtga ccataggtga     2460

tgatatttgg gatgagaact ggttacctct acaggctaag atgggaaaag gaggtgatgc     2520

tgcctcccat ctatttactg caagccttgg tggaaagaat cagtattcat catgtaaaga     2580

aatgccacag aaggactggt gtttttctac ccctaaagat acatgggatg attcttggca     2640

gccttcaggc cttgtaaatg gaacgaaagt agaagttcat aagccagaag tactgggtgc     2700

tcaggaaaaa aatactggca caaacaggac tcaaaagcaa ctagacataa atggttcttc     2760

agattcttcc acactgccca aattggaaga attctgtacc tctcttaccc agtcagagca     2820

gtcagcagac gggagccagt ctgaacccaa caacagtcag actcagccaa agcaaattca     2880

gctttccaca gcagcaccct gttcaacaac tgcagtggat gattccgcag aaaagccctc     2940

tggttctgtg gaaagctcac cagagatcct aaagaatgaa gatttttcta gcagccgtgc     3000

tattacattg tacaaagaca agcgtcaaga atctgtagac cagctgtctt tgattttgtc     3060

ttatgagtgc cagatttctc agaagctcta cattcctcga agtacagcca ctgctgcctt     3120

aggtgctgcc gcacggttag ctacatccag gagcctccta cactggtacc ccagtgtgaa     3180

aaggatggaa gcatgaggga gggagggagg agggagaaaa acagaatcca gccgcttagg     3240

ctttgatgaa ctcccaggcc aaaatgagga gttattgaag caaaatagta tcttgatcat     3300

tgatactttt gtctttctgt gactatatgt tagctttatt atgctaacag tctactttga     3360

tgtgtaagta agtattgata tttactgtta atcttgattt ttcttgattt tattctgtgt     3420

cattttgttc acctttgttt ttaatgtagt ttaaaggaat ttgttttttt gtgtttgttt     3480

ttcttgtaca ttatcatgac tgataaatga aaattgaaaa actaa                     3525


<210> 628
<211> 5448
<212> DNA
<213> Homo sapiens

<400> 628
ttcaaattct cccaagctgg aggtagtgga gcaaacaaga tcagcaacaa tgagggagca       60

gctgcaccac tttgtgttac tctctgatgg ccagcacagg gctgcaagta gtggctgcaa      120

aaaccagaca aatagatgga aatccaggaa ctagaggaaa ttcaggcctg ccaggggctc      180

tgggaagtgt ttgttactct ctcagaaaga gccagggatt atctgcacaa aactggaagg      240

tttattgtga ttggcgggat tgtctcccct gtccacgact cctatggaaa acagggcctc      300

gtgtcaagcc ggcaccgtct catcatgtgt cagctggccg tccagaattc tgattggatc      360

agggtggacc cttgggagtg ctaccaggac acctggcaga cgacctgcag cgtgttggaa      420

caccaccggg acctcatgaa gagggtgact ggctgcatcc tctccaatgt caacacacct      480

tccatgacac ctgtgatcgg acagccacaa aacgagaccc cccagcccat ttaccagaac      540

agcaacgtgg ccaccaagcc cactgcagcc aagatcttgg ggaaggtggg agaaagcctc      600

agccggatct gctgtgtccg cccgccggtg gagcgtttca cctttgtaga tgagaatgcc      660

aatctgggca cggtgatgcg gtatgaagag attgagctac ggatcctgct gctgtgtggt      720

agtgacctgc tggagtcctt ctgcatccca gggctctgga acgaggcaga tatggaggtg      780

attgttggtg actttgggat tgtggtggtg ccccgggatg cagccgacac agaccgaatc      840

atgaatcact cctcaatact ccgcaaatac aaaaacaaca tcatggtggt gaaggatgac      900

atcaaccatc ccatgtctgt tgtcagctca accaagagca ggctggccct gcagcatggg      960

gacggccatg ttgtggatta cctgtcccag ccggtcatcg actacatcct caaaagccag     1020

ctgtacatca atgcctccgg ctagcagccc ctcgtcctcc ggcaacacaa tggcccctcc     1080

atctttgtca gccccctgtt tctctcctgc ctctctgttt ctccatctcc tcgtcttgac     1140

tgttttccct acttgctgac ttaacccccc atagtgtggg ggacctgcag agaaccatgg     1200

cattccctat tccacagtca tctttggaca gactttcctc tagtctccgg gttgggggtg     1260

ggtgagggaa tggggtggga gtcgggggaa gtgcagtcct tggagatgta ctggtgtccg     1320

tctcccagca tgctctagag aggcggctct ggtgcccatc ctcccagcac gctctgggga     1380

ggcggctctg gtgcccatcc tcccagcatg ctctagagag gcggctctgg tgcccctcct     1440

cccagcatgc tctggggagg cggctctggc tcttgccttc ccagcatgcc ctttactaca     1500

aagggctatt tttcttttct ttcttttgtt tatttatttt tctttgttca ctccctgtag     1560

aacttggatg aaatcagtgt ccatggttct ttatgtttgt agtcttgatg tgctcctgtg     1620

gtattacttc ccctctgata ggacattgta gccagcctca gcactcagtg agttcatcag     1680

ggccacaccc agtagagaag gccaagcaac ctccacttct tcagcaccac acacacgcac     1740

acacacacac acgcacacat gcgtgtgcac ccgcgcacgc acatacacac acacatatag     1800

cagtagcagc agcagcagca gcagcagcaa cctttgatca ggagtgagat tttcgggttc     1860

tgaaacctgg gacacgagtc tgtgaatagt cggttttctc agaataattt gaatctgttt     1920

tcttagtttc aaatgaccat ttccctgatg ctctgagctt atgatcacac agagccagtc     1980

catcctcatt tcctggtggc atctgttcat ttacctttgt ggactgtagc tgatggcaca     2040

gtgcgggttc cctaccagcc aggggtttcc aagggacctt tggaggccat gcttagacac     2100

attcctgtac ctgagaacaa ccacataggc aggaccagat ccacatcgtg cagtcgtgtc     2160

ataaaaaaac aaaacaaaac aaaaaaacac taggagtcca ctcaaccctg gaggtctttg     2220

ctaattggaa ttatgtattg tctgttgggc tgggaaatgt ctctttcata ttgtaagtcc     2280

aggatgaact aggagaaagc aatttgttgc cctgatgata actgatgatt ttcaccctct     2340

ctagctgagg taactcagac agtgcatgag gtcagtttct tcttgagaag cagtgccttg     2400

gtcttgtttc tgtggttggt tctagcccct gcagagcctg ggagctgcag gaactgtctg     2460

agaaaatctc cctaataggg gagtgggttc ccagaaggga gatctgggag gggtcaggag     2520

ccactaagtt gcttcactcc ttttttctct aattttctac cttcctctct gttcctgcag     2580

acagttttgc cagctttgct tctggttact agggtctcat gcgtgtcctg cttggagagc     2640

cataaggaaa ttgctgtctt gtgctttgtg tctctcatcc agtctctggc tcttgggatt     2700

ctggtctttg agaaatagtc cctgagtatt aggatacttt tatcaaaatc tagtaccagc     2760

tacggccaga aagggccagg tgggacctga aagcaaagac aatgttcttt accacacgtt     2820

tcacatctgc aacatccttc aattgcggga aaaggaactt gatttaacag aagaacatgg     2880

tagagcagca tccagaaagt ctgttattcc tcttggattt tttgaaataa tcttcagagg     2940

aaggaaggaa aatcctattt tggggtatca gtgtttgact agggatcatg aaataataaa     3000

ctgaaaaaaa ctttagagtt cagttgatcc aacactttcc tttaaaagtt gagggagcag     3060

aggcccatgg gattaaatgg ctggtccagg tcagccagca ggtgtagggc ctgacaagaa     3120

catattgttt ccctgacccc taggccgtca caccacaccc tccatttcct catgttgctg     3180

accaggtgcc catatgattt ctacacttcc caagccttac cctggcatct ttcttttaaa     3240

ttatatctgt cccaggtgct ctccacacat aggatggtaa tgccagtccc aggggagggt     3300

gtgatagtaa ggaaggccac tgttaggttt cctttagaaa taaagagatc tcagcagctt     3360

ggaagaaatc ccagaagcgg actccatcaa tccaagaaag agttgctttg tggaaggtga     3420

aggaagaccc acagagtgct caggatgatg ctattgctgg agagcgaaag atggaacagc     3480

cttgtccagg cagaacagtc ataagccagg aaatgaaaca aaggaaaaca ggtgcctgaa     3540

tttcctgggg aaacatggct tgtttaagga cttggagtta tggatggaat ttatgggacc     3600

cacgtgagca gacctgagga aggctcgatt tcttttgttt cttggtccac tctgtcactc     3660

tgctctggtc aagccccatt tggtctacag cccatgagaa ggaatgaggc tggttctgca     3720

ctctcagcat gcagtccgaa agcatgtggg agtggggagg gaaagtgaga tgaattaaga     3780

caaagaacag gtgccataga agtagatttc taggaatgaa gtggggcaga tcttatcttt     3840

gtggattaca ggcactgtac taaaaacagg tttcctattt aatataaaaa gaaagtgaat     3900

cttcttttgg atagaatcat ccattcccat cgccgcaccc cctacccccc aaacacacac     3960

acacacacac acacacacac acacacacac acacacacac acgccctact cttcatttgc     4020

taggggaagg tcacagcaca actaaatcca ggacaggaca ttgtgaccat gacccagcca     4080

cagtcaatac cagaaagatg attcagagtc tgaagtggtg ccccaggtgc caacaggata     4140

acctctaccc cccgactttg tctctggggt cctgttcctt cctgcaaagc ccaatccaag     4200

actggcatgg ctcagaggtt gtgagaaagg catggactgg aacaatcatg tccagagggg     4260

tctggagctt tgtttcctgt tcaccagcaa aaaatgtctc tcccattttt ctgaaagtgg     4320

ctgatgtaag aacaggcaga aggaaaaccc tttttgtcaa taactctgtc cttaaggaat     4380

ggtcctctgg gagggctgtg ctgctagtgg gtacctcagt cacacacccc caaccccagg     4440

cagcctctag agccttcttg ctttcatttt ccttgaatgt acataggaac aagggggaaa     4500

gtctcttact gaagtgcctg aaacccaaag ctagagcttc tagagacgcc gttcttcctg     4560

tctcagcttg gccagccttt caacaatgtt ctctagtttc aagctccagc ttctcagaaa     4620

gaattaaaga acttgctgtt caaattaagt agaaagtgag actcaataat aactgaacta     4680

cagcaaaagg cagagaatta cagggagaaa aaacttgtac ttaccagccc aattctactc     4740

tcctcaaact gacacacaca cacacacaca cacacacaca cacacacaca cactctttta     4800

ggggactaag agagagaagc atgttattac attttactca tccaaacagt aatgcaaaaa     4860

taaaacggta gaatatgaaa agctcaggat ctctcccaag gctacctact gcaggagggc     4920

caacaggtga gatgggaaga atggaaacag ggaccgattt tgtagctcat acaattagga     4980

caccttagga atagcattgt agtaatggtg atgaatatgc tctgccaaat tcatccagtc     5040

tgcaccatct tatagctgcc cagcacactc gactgttcat gtggtctctt tgtagtgtga     5100

gtttggagtg tcctattagc ctgttctggt taggaatgag ttaacggctc tttccctcaa     5160

ccttagtcta gtcccagggc tgaggattca gctggatcca catggtcttg agggttggca     5220

tgaggagggg gaagcttttt tgaatcgctt tttgatcaca taatctgcca ttttaagagt     5280

aagatttgct ttatggaaat caattcatta ataaaaaatg atattcaagt tgcaatacca     5340

tttcacagtg aaatattttg agtacaattt tgttgctaga atagtcatgg gcaagagttt     5400

tatgcaaaat gtttcaatta tgttaataaa taagacaatg ctacaaga                  5448


<210> 629
<211> 1265
<212> DNA
<213> Homo sapiens

<400> 629
gctgcgggcc tccgacggcg ggaggacagc gctgcgagga ggcgcccggg acagtcatgg       60

agcgccgcct gggagtgagg gcctgggtga aggagaaccg gggctccttc cagcccccgg      120

tctgcaacaa gctcatgcac caggagcagc tcaaagtcat gttcatcgga ggccccaaca      180

ccaggaagga ctatcacatc gaagagggtg aagaggtatt ttaccagctg gagggagaca      240

tggttctccg agtcctggag caagggaaac accgggatgt ggtcattcgg cagggagaga      300

tattcctcct gcctgccagg gtgccccact caccacagag gtttgccaac accgtggggc      360

tggtggttga gcgaaggcgg ctggagaccg agctagatgg gctcaggtac tatgtgggcg      420

acaccatgga cgttctgttt gagaagtggt tctactgcaa ggacctcggc acgcagttgg      480

cccccatcat ccaggagttc ttcagctctg agcagtacag aacaggaaag cccatccctg      540

accagctgct caaggagcca ccattccctc tgagcacacg atccatcatg gagcccatgt      600

ccctggatgc ctggctggac agccaccaca gggagctgca ggcaggcaca ccactcagcc      660

tgtttgggga cacctatgag acccaggtga tcgcctatgg gcaaggcagc agcgaaggcc      720

tgagacagaa tgtggacgtg tggctgtggc agctggaggg ctcctcggtg gtgacaatgg      780

ggggacggcg cctgagcctg gcccctgatg acagcctcct ggtgctagct gggacctcgt      840

atgcctggga gcgaacacaa ggctctgtgg ccctgtctgt gacccaggac cctgcctgca      900

agaagcccct ggggtgaccc tcttgccatg gcctgaagca gccacaggtg tgccaagcac      960

cctcgagtgc catccctgcc aaacaactct cccagccccc actacctctc tgtgtactgc     1020

cgctgtgtcc cccacagacc tgcacattgt tgtcacccac cctcctgccc ttctcagccc     1080

agatgccatg cccctgggcg ggcagcagct ccccatcttc tctggcagac tcagcccact     1140

gccttgccag tcttgccagg tggtctaccc ccggccccgc tcctgcccat tcctctgtcc     1200

ctgcagactc agtgcagcac ttccacacca agaaggccct caataaaggc ttcctgagga     1260

acgca                                                                 1265


<210> 630
<211> 6866
<212> DNA
<213> Homo sapiens

<400> 630
cggagggagt aggagagccc ggggcttcgg caggcagagc aggcctctcc cctccgtcct       60

cgtcgtcctc gtcctcctcc tcctcctcct cctccgtggt ggtagtggtg ggacttcccc      120

cggctgctgc ccctcccgcc gccgctgctg tcccccaccg aagtagcggc cacagcctgg      180

tcagcggcag catcatgcag gccaatgggg caggaggagg aggaggaggt ggcggcggcg      240

gcggtggagg aggagggggc ggcgggggcc agggacagac cccggaactc gcctgcttgt      300

cggcccagaa cggggagtcg tccccctcgt cgtcgtcgtc cgcgggggac ctggcccacg      360

ccaatgggct cctgccttcc gccccctccg ccgccagcaa caatagcaac agcctgaatg      420

tcaataacgg ggttcccggc ggggcggccg ccgcatcctc agccaccgtc gcagctgcct      480

ccgccaccac cgccgcctcc tcttccttgg ccaccccaga actgggcagc agcctcaaga      540

agaagaagcg gctctcccag tcagatgagg atgtcattag gctaatagga cagcacttga      600

atggcttagg gctcaaccag actgttgatc tcctcatgca agagtcagga tgtcgtttag      660

aacatccttc tgctaccaaa ttccgaaatc atgtcatgga aggagactgg gataaggcag      720

aaaatgacct gaatgaacta aagcctttag tgcattctcc tcatgctatt gtggtaagag      780

gcgcacttga aatctctcaa acgttgttgg gaataattgt gaggatgaag tttttgctgc      840

tgcagcagaa gtacctagaa tacctggagg atggcaaggt cctggaggca cttcaagttc      900

tacgctgtga attgacgccg ctgaaataca atacagagcg cattcatgtt cttagtgggt      960

atctgatgtg tagccatgca gaagacctac gtgcaaaagc agaatgggaa ggcaaaggga     1020

cagcttcccg atctaaacta ttggataaac ttcagaccta tttaccacca tcagtgatgc     1080

ttcccccacg gcgtttacag actctcctgc ggcaggcggt ggaactacaa agggatcggt     1140

gcctatatca caataccaaa cttgataata atctagattc tgtgtctctg cttatagacc     1200

atgtttgtag taggaggcag ttcccatgtt atacgcagca gatacttacg gagcattgta     1260

atgaagtgtg gttctgtaaa ttctctaatg atggcactaa actagcaaca ggatcaaaag     1320

atacaacagt tatcatatgg caagttgatc cggatacaca cctgctaaaa ctgcttaaaa     1380

cattagaagg acatgcttat ggcgtttctt atattgcatg gagtccagat gacaactatc     1440

ttgttgcttg tggcccagat gactgctctg agctttggct ttggaatgta caaacaggag     1500

aactaaggac aaaaatgagc cagtctcatg aagacagttt gacaagtgtg gcttggaatc     1560

cagatgggaa gcgctttgtg actggaggtc agcgtgggca gttctatcag tgtgacttag     1620

atggtaatct ccttgactcc tgggaagggg taagagtgca atgcctttgg tgcttgagtg     1680

atggaaagac tgttctggca tcagatacac accagcgaat tcggggctat aacttcgagg     1740

accttacaga taggaacata gtacaagaag atcatcctat tatgtctttt actatttcaa     1800

aaaatggccg attagctttg ttaaatgtag caactcaggg agttcattta tgggacttgc     1860

aagacagagt tttagtaaga aagtatcaag gtgttacaca agggttttat acaattcatt     1920

catgttttgg aggccataat gaagacttca tcgctagtgg cagtgaagat cacaaggttt     1980

acatctggca caaacgtagt gaactgccaa ttgcggagct gacagggcac acacgtacag     2040

taaactgtgt gagctggaac ccacagattc catccatgat ggccagcgcc tcagatgatg     2100

gcactgttag aatatgggga ccagcacctt ttatagacca ccagaatatt gaagaggaat     2160

gcagtagcat ggatagttga tggtgaattt ggagcagacg acttctgttt aacttaaaat     2220

tagtcgtatt ttaatggctt gggatttggt gcaaacaaac atgattgata gctggacaga     2280

catgctcgtc atgaaaaaag aaccatttct gaagcccgat tggggccaaa catttacacc     2340

ttgcttcata gtaaccagtt gagatgaagc acgtcgttag aacgttgttg gacaccatgt     2400

tgaattattc ccccatcggt tgtgaagaac tgtgctacat tcaggcttac ccattgaact     2460

cagtatatat atttttttcc ttcctgtctt ttgtctggca ggataccatt cttgttgctc     2520

ttctgtgtaa tgaagtttaa atgcttgttt ggaaaacttt atttaacagt ttagaaggct     2580

tgatagaaag agtgcattag tctgaagagt atacattgga taggaaagaa tttccttctt     2640

ttgtttctcc aaatctttcc gccttattta gcttgagatc tttgcagctt ggttcatgga     2700

ttctagcctt gcccgttgcg cagtatatac tgatccagat gataaaccag tgaactatgt     2760

caaaagcact ctcaatatta catttgacaa aaagttttgt acttttcaca tagcttgttg     2820

ccccgtaaaa gggttaacag cacaattttt taaaaataaa ttaagaagta tttataggat     2880

taaagtgact tcatttgtat acatttggaa tctaaaccag cttaaaaaca gtttcctcaa     2940

tgacttagat acacagtata actgatgctc ttctggaata ccacatgaga catggtcaga     3000

aacagtgctt ggaaggacat tacacaagaa attcagagta atgctttgaa gatttccccc     3060

cttttgtttt attcctgaag gaacatcagt acccgatctt gaagaaattc aagattcaaa     3120

aagaatttta aatacaccaa catgagacat cagtagtcag ttggttttca gtaaagcttg     3180

ttccaagttg ttctcaactt aggaagtaat tttggtgtga tctagcaaaa gagtaggaat     3240

cagcgataca accactttgg aagtttatag tataattgaa attattagaa gaattcagca     3300

ggttacagac atacttaaac tgggattaaa acctcatagt catttttctt aattgccctt     3360

aatattttga catataggga tacataaatt taaagaatat tttttctcag ttttttcaga     3420

tattgccata ctgaacctca ttctaaactg gtgctgtgga tagtctttcc ctctcccctc     3480

ctgttttagt ttaaggaaag gtttccttca tggaaaagca cttttaattt tgagaatttc     3540

acatttaaaa taagccaaaa gcctgatgtt cacattgtgc ttttaaactc cgtaacagct     3600

gaatacaaca taacatagtc tcccttgaaa ttccctccct ttttcagtag aggataaata     3660

gggtgactcc agctgttgga atgagaatgg ggataccccc aaaataagat tctggtgaag     3720

aaaaagtctt gtactaagtt cccctttagg tgtagccaag tctataatat aattatgatc     3780

atgaatagac tccagaatcc acaaagagaa gagggcttgg atgtcaaaaa ttcttccatt     3840

gtggggtagg tggtcgggga tgggagaaag ggaaaagtca gggaagggga gaagaaagaa     3900

aaacacattt ggccttaaaa tagcatgcat tctcccagaa gcccatagta aagaaaatga     3960

cagatcgtgg tcagcagact cttatcaaat tggtatgtaa aagatttctt caagctccat     4020

tttgcagaga ccaccactta gagaatcaaa aaattcctgt tttgatactt ctaagttaaa     4080

atatatgtta cagtttatct ggtacttcat ttttcttaac taaaattact ttttacttta     4140

agcttgaata aaaatcttca ttggtaactg tatgtaatta agtggcaact tctctttacc     4200

tcagtatagt taaaaaccat tcatatttta agtgattcat gtataccctg aagccgttaa     4260

tacaccccag tctctatggt aacatcacta aatgtgggca tagaaactcc acagctgttt     4320

acaaatttgg ttacagtgtg ctacggtgca tttgtaacac tcagatttgt gcccattcag     4380

gggcaatttg gcactcagat tctactctac ttcacctaac cacccctaga tctgagtttt     4440

cagagtgctt ctgaagtaca gtttaaaaac actttttaaa aagtggagta aaagtgaggc     4500

acattttaca agaacataac tcctattaaa acggagtaac aactatgcaa aggtttctat     4560

agcagctagg tgagtttgtt ttccgggtct gtcttaactg gcagcttcct gtacatactg     4620

gtacttattt gctgtaaacg tctgtttcat acatttgcca tgcagtgact gtgctcgaaa     4680

ggtgaaatca atggtaaaga agcctaggat tttatggtat gagaaactga tcgcaggatt     4740

ttctgatcca tagctattaa ttgaaaactt ctgatagtgc tgtaggctct atagtaggct     4800

taagagtgag tcttatacta tgaagccagc cacaagatac taacaaatgt ataaattgaa     4860

aagtaccaat actttttgca catagatcaa aatagagtgg agaatttggg ctccaaaaat     4920

caggttagta ggctcatttc catgtgctta aaaatgtttt tgttgttatg cattgattaa     4980

gggctagagc aaatataaaa ttaaatgtct ttttcctcca aataattggt tattaatggt     5040

aaaatgttgg acttggggat tactgagatt agtatgtggg tagtaaagaa ttggagtggg     5100

agttagtggg gagggatgac aaagcttcag ctttggtttt tgtatttttt tagtcttcat     5160

aacagctaca tttctgttgc tcttattggc cagataaatg tgttatatta aaccaggtaa     5220

gtattttaaa cagagaacat tttatttgca tatatcccta caaattggcc cattttattg     5280

ggtgggggga taaaaaaggg attccctaac tttaaataat cagaatatcc tgcaattgaa     5340

aggagaaaaa aatccaattt tgtcagtatt ttcttagtct gaaaaaaaca gcagtagtaa     5400

tctggtgaat gttattatta ggagtgttct gcctctacag tggcatattc catgacatta     5460

atagaaaacc cttctttccc acccctcccc atcttgacat tttctttttt aggatgttgg     5520

ttcctgcaaa caagaactga ccctatcacc tctgcctcac agtgggtaaa tatatcatac     5580

atctcttgaa agggaaaata tccatgtcag tttctttcac agtagaagaa tggctgcttt     5640

tgaatgggga ggaaagaaga catttttctt aatatccttt ttgtcccatc tctaaaatgt     5700

ataaatattt tgatttggtt ttactttaat ttctcattca taatttcgca actgtccttt     5760

tgggttgccc tccaacacat tacttccatt tcagaaacca tatctgattt aatataaact     5820

gctaacttaa gaagaggtga atttgcattt acacttagac actttctaaa aacagggtga     5880

acttaattga aatttttcag tgttgttaag ctattgttat agtagctgcc ctatagttac     5940

aaaaataaaa actataaaaa cccatcccct atctacttaa tccagatagc ctggatttaa     6000

caaaaccaat agtataaaaa tgtgtgtgtg tgttctgtgt gtgtgtgaga gagagagtac     6060

ttgattcatt aaaaagtcct ggaaacagct gttctaggat cttgtcattt ttactgaaag     6120

tctcgtgcac atgtgaagtg ccctctgagt ttaaggtttg gttaatactg gtatattttt     6180

ataagattga aattgtgtcc ccatctttaa cttaaacatt ttcattatca gggtcaatgt     6240

gctagaactg aattgtaaca tttttaggca cagatggaaa aaaatgttat tggctccttg     6300

aaaatgtgtg tgtgtggcga ggggaataga tccacaaaag catgtatgta cttacaaacc     6360

aagctgtaga gatcaagaaa agaacttaag tgttgatctc aagatttcta aattgtcaag     6420

atttacatgg cattgtggtg gaactagtta acacttagag cttttggtat gtaataacta     6480

tttgctatgg actgattaaa tgtttcaaaa gattgtgttc ttcaattttg gtgggttttg     6540

atttttgttt ttttaactgc ctctcagatt atatttactt agtttaaatt tctttgcttt     6600

attcattaaa gtataaaaac ttcaggtctc tgatatttat tttcacttgt ttactaatta     6660

tttacaaaac accctttgtt gacttttatt ttataaatgt gtaatgtatt aaacgtcttt     6720

aaatttttgt tcaactgaaa ctacattaac tttgatttgc tttactggga ttttttttta     6780

aagacacttt ttccatgtca gtgcgcagca cttaaccagt cgtttgtatt ccctttcttt     6840

caatccaata aacagaatga atacct                                          6866


<210> 631
<211> 5326
<212> DNA
<213> Homo sapiens

<400> 631
gcgtggtcgt cgccaccgca gccgcccgag aggagctggg ggaggacggt ggcccgcgag       60

gctcgtcgca gacaacgcgg cggcgatgtc cgcgagccag gcgagtgccg cggcggcagc      120

ggcggggcct tgcgcgcggc agggcggcct gggcttcggc ctccctccgg ttccctggaa      180

gcgggcccgc gaccagcgcg ggagcagcag cagaggcgga ggctccagcg cgtctctctc      240

ctccccctca gcctgagccg ggggaagcca ggcggcccgg gtgtctggag ggggggggtc      300

cgctgcccga gaatgggaat tctcttcact agaatatgga gactgttcaa tcaccaggag      360

cacaaagtta tcattgttgg gctggataat gcagggaaaa ctaccattct ttaccaattt      420

tctatgaatg aagttgtaca tacatctcct acaataggaa gtaatgtaga agagatagtg      480

attaataata cacgtttcct aatgtgggat attggtggcc aagaatctct tcgttcttcc      540

tggaacactt actatactaa cacagagttt gtaatagttg ttgtggacag tacagacaga      600

gagaggattt ctgtaactag agaagaactc tataaaatgt tagcgcatga ggacctaaga      660

aaagctggat tgctgatttt tgctaataaa caagatgtta aagaatgcat gactgtagca      720

gaaatctccc agtttttgaa gctaacttct attaaagatc accagtggca tatccaggca      780

tgctgtgctc taactggcga gggattgtgc caaggacttg aatggatgat gtcacgactt      840

aagattagat gatctctact gacctcttct catagatttt gtataaatga agtgctggac      900

tttacctgaa agctgcaaaa attaatggtt tagatatatt tataataaac tgatttaaac      960

tttttctata agaagaaaaa ttaagaccac ttatttgaaa acaaagatga agtctcacct     1020

tccagtttgc tttctcatta gttttttcca aagtaagtta ttgaagctgt gattgacatt     1080

tttctcataa tgaatcctct caggacattg tgtagcctat ggtaagtaca aagggagagg     1140

aagacatttt gaattttaag agctttatta tcagtttaac cctccctagt tgaatgttat     1200

tttcttcttg ttccattaag tcagaataca aatcagcaca gatattcgaa tgtttccaat     1260

attttaaaat gtaatgttac ttatgaaaag tattttgctt aaggttgtgt gtgtattgtg     1320

tatatacctc aagttcaagt taatggcatt gatttatgtt ccagacaaaa ataacacaaa     1380

taataatatc cttcgttata accacaatga gataagtatt ggcattagtg ttcagtgcca     1440

ttttatactt tctctctgtg ttctctgtat tgtactaacc aacctcccaa atcgctgagc     1500

tgcttgttta aaaaaaaaaa aaaggaaaag gaaaaagcat gacattgtgt atcgattttt     1560

tgttgttgac caaaatcaca cacatggaaa catgtaattc aacagagtgg gaaagctagc     1620

agattcttgg cttagtatta ctaataggca ggattgtaca atgagcaact atcagattat     1680

tcctttcagt ggttcttatg gcatctaaat tactgaataa attattaatc cattaatcag     1740

tgaatcaaat tatgattaca attatcaaat gaatgctcag cattaattga aaactgtttt     1800

gtgaaacatg tctacccaga aaagtagcat tctataaata ctattaaaca acttagctat     1860

attattttta agtattaaat tatatgtcaa gcagttaaag tgaatttcag agtaaaagta     1920

aggcatgttt ctgagcaaca ttgataattt cttaatttgc aaatttcttc ttattttggt     1980

acttggaata tagtgtgaga ttttttattt ctaaattttg ttgtatcttc tattacataa     2040

atgcattgac aattataaaa tgcaagtgtt ttttgaatga ttttaagaat ttggcttaaa     2100

aattgattga tacaacgtat tatttgtact aagaagtaac ttgacccaaa acacctttta     2160

tgtttgctta gggtatattt tttcagtgtc tgaaagtcaa aggtattcct gtcacaactg     2220

taaacaaact tatcctaaat gtgttaaaac atattcttgg gtactctatt tatgtatctt     2280

tcatgccttg aaaatctgaa ggttaatcca aactcacatg ttttagcata tttgagaaaa     2340

aaaaactacc ttcaatatca gccttttaaa tttcatgaag attttggtga ggaataatag     2400

tatatagttt aagtattgac aaaactttga aagtttcttt ctttaaaatg ggaaatactc     2460

aatatctaaa tccaggtcag gcatgggata tcagtattta acattggatg ttttatgttt     2520

tatatttata atgttcaaaa tgcaagcata acatttaata tttgtccaca tggttttaca     2580

aaagtaaatc ttaaattact aagcttttcc catatgttct cgtactttct caaatcccta     2640

taaagaatta cttgttatct attaaaaatc tcctttaccc aaatctgtat tatggtttcg     2700

ccagacaaat attatgtgat gtagcccaga aaatccacac cttttgtcct ttttatgttt     2760

taatttgaat aatcatgtgc ttagtccctt ggattactgc cacatcagtt taacacgata     2820

tcagcacatt cccttgtcat catcaaggtg ttggctcaga tttattctta attggatgtt     2880

taaagcatgt actaccttgt tacagttggt ttagtgtagt ggattattga catgacatca     2940

tgagaagatg tgtaatttta taccacattt ataaaacatg attttgtttt ctacccttca     3000

aggtaaacat taaaaataag gtggtacttg tgtacttgta cataaaacca aaattatagt     3060

tgggaaaaaa ataaatttat atatgaaaat gtcaaaatca ttttaaaagt attattttca     3120

aataaaatgg agaagctggt gaaaagtcat attggcaatt tttatgtagt ttaagtggaa     3180

ttaagcagag ggagatgctt ttgggttttt aatatgccac ttctgagtga aaacatctcg     3240

tggagtcatt gtgttcagct ctgagaagaa caaagattca tagttctgta catgtggctg     3300

gatttaaata tcctgttttt gatactaatt ttgaaagtca tgtaacttct tttgatatct     3360

gggcaaaagt aaccatatgc tataagcatt tgaatatgtt taattttatc ataatagcat     3420

ctgtaaaagt acatcttaca cattatatag agggttcttg tttgaaattt tcagttctct     3480

ttatcttccc agtacctctt ggtcctcata atgggcaaag gatacaacga aggcaggttg     3540

tataggggtt atagtgggga agtggatagg ggattcattt tcttatgtga cattttgcct     3600

taagaatata aaagtgcttt agcactgatg gctggcattt ttaatatagg cagtgaaagt     3660

gactttagaa gcatgggatg aaatagaggg aagaagagtt tttattttct ggcctttaaa     3720

aagtgcctag taggtcattt gagacccaga gaaatgcaca gagcttgagc aaaggcatga     3780

agtccctgac attgttttcc tttttgtctc agcatatagt attaagatgc ctagaaatag     3840

gactctattg ttccctcttg tataggcact ttacatttct tgtcactaca gcaaccacat     3900

acagtacaga caacctccaa acctgtttat attagtgtaa atagaaaatc tatagacaac     3960

tttctagttt tctctggagg catttttggg aatgtacgtg taataggctc tgctttgtat     4020

acaggagata ataccacatc atcggttatc tccaaactcc agtcttctct caactgccca     4080

gttgtatgtt gtcatcaatc actttttcaa ggctgggtag agacaagttt ctcctcgtaa     4140

ctttgacctc tcccactctc caaatgtaat ctggacctca ttgctttcaa ggtcagcttc     4200

cccatagctc aggtatcctt tgctctcctg tatcttcatt tactattagt gaagagatct     4260

ctgtcctgga ggttattcta aactttcttt gtaactattg ttatagacaa tggtttccaa     4320

accagtggtt tctatgtagc ttttctagtt ccttgctatc ttctcaccac tggcttgagg     4380

tagtgatttg gactttgctc attagagagc attatcagag atgtggagtc catcagaaga     4440

ccagcttgca gtgtgtatag catatagatg ccaatattag aattctttaa attatattta     4500

acattttcat gcttcttaat ttaacttcac atgttgggaa gtagattcag aaagatagga     4560

gaaataccca gactctacca cttccgtgag ctactagtta ggcatgggca ggattaagtt     4620

ttatgtgtat tatcttccca ctaccaagaa tggttatgtt tcacagaata ccagttcagt     4680

ttgatttgga aaaagatgcc aaaccaaatt tatatgtagt ctataatcta agggcattct     4740

tgaaactatt gcccacatcc catttttttt ttcatgttta cttacaaaac agagataaac     4800

attagatgtc taaaggagtt agtaatgaaa agcctatcct taaaaaataa acctgttgaa     4860

atgggcttta aagacatcga aataatcact tgtcatgcat tgactgtaaa tgcagataga     4920

gaaatatgtc tttgaagctc cacttacaca aaaataaaac ttgtatatca tgctccctca     4980

aagaatgtgc gatagattat tttaagacca tgataataga gtaaaaagga aagaaagcca     5040

gaaattacaa ttttggatgc taaaaagtaa ctttctagtt aaccctaaag tcctgtcaga     5100

ttgtgaagaa atgttccagg atacacttgg attagttatg cagtatttct tatcaatgtc     5160

tagcccttgt gtattgttct gaaaactaaa gtttaaatct ttatgctgtt gcttgctaga     5220

tatcctgttc tttggtagaa aattcccata gtctgtactc aagaagtgcc taaaaatgga     5280

tttgtgttga ttttaagccc atctaataaa ttatatgtat tttcta                    5326


<210> 632
<211> 1775
<212> DNA
<213> Homo sapiens

<400> 632
gcctttttct tcccccagta ctgaaattaa gcagcatcca acacaggcct actcttacga       60

catgtgactt tactgttttc cgtttttgtt gaaagagtca ttaacagtta ggagttgatg      120

gcagtttcaa taacaggtca ttgccgagaa aaggatagca ctataatatg cagaaatcta      180

caaattctga tacttccgtg gaaacactga attctacccg ccaaggcaca ggagctgtgc      240

aaatgagaat caaaaatgcc aacagccacc atgacaggct cagccaaagt aaatccatga      300

tcctcaccga tgtcgggaag gtcactgaac ctatatccag acacagaagg aatcattcac      360

agcatatctt gaaagatgtc attcctccat tggaacaact gatggttgaa aaagaaggtt      420

atctgcaaaa agctaaaatt gcagatggag gaaagaaact aaggaaaaac tggtctactt      480

cctggattgt tctttctagt cgaagaattg aattttacaa agaatccaag caacaggctc      540

tgtccaatat gaaaactggg cacaaaccag aaagtgtgga tttgtgtgga gcacacattg      600

aatgggccaa ggaaaaatcg agcagaaaga atgtctttca gatcacaaca gtatcaggaa      660

atgagttcct tctacagtca gatattgact tcatcatatt ggattggttc cacgctatca      720

aaaatgcaat tgacagattg ccaaaggatt caagttgtcc atcaagaaac ctggaattat      780

tcaaaatcca aagatcctct agcactgaat tgctaagtca ctacgacagt gatataaaag      840

aacagaaacc agagcacaga aaatctttaa tgttcagact gcatcacagt gcttccgata      900

caagcgacaa aaatcgagtt aaaagcagat taaagaagtt tattacccga agaccttccc      960

tgaaaactct gcaagaaaaa ggacttatta aagatcaaat ttttggctct catctgcaca     1020

aagtgtgtga acgtgaaaat tccacagttc cgtggtttgt aaagcaatgc attgaagctg     1080

ttgagaaaag aggtctagat gttgatggaa tatatcgagt tagtggcaat ctggcaacaa     1140

tacagaagtt aagatttatt gtcaaccaag aagagaagct gaatttggac gacagccagt     1200

gggaggacat ccacgttgtc accggagcac tgaagatgtt tttccgggag ctgcctgagc     1260

cgctcttccc ttacagtttc tttgagcagt ttgtggaagc gatcaaaaag caagacaaca     1320

acacaagaat tgaagctgta aaatctcttg tacaaaaact ccctccgcca aatcgtgaca     1380

ccatgaaagt cctctttgga catctaacta agatagtggc caaagcctcc aagaacctca     1440

tgtccacgca aagcttgggg attgtatttg gacctaccct tctgcgagct gaaaatgaaa     1500

caggaaacat ggcgatccac atggtctacc agaaccagat agctgagctc atgctgagtg     1560

agtacagtaa gatcttcggc tcagaggaag actgacagac aagacaagct actgaatacg     1620

ttcacatctg tcttgatgcc taatattttt acatttctgt aaacatattt ctgaaatatt     1680

ttttgccttt caagcgacag atgcctcatt ttgtgaaaac ttaatgatga ttttgtgttt     1740

aagttccaaa catttgaata aaataattga caata                                1775


<210> 633
<211> 1505
<212> DNA
<213> Homo sapiens

<400> 633
tcacccaagc gactgggagc cgcgtcctgc tctgggactg agccgttgga gctgccccgc       60

tgaccgcact aggctgaccg caaccggctg accacacaca gtcctcactc ccctggccct      120

ggtgggcggc aggcaccatg gcgcagacag tgccgccctg cgagctgccc tgcaaagagt      180

acgacgtggc ccgtaacacg ggcgcctaca cgtcctccgg cctggccacc gccagcttcc      240

gcacctccaa gtacctgctg gaggagtggt tccagaactg ctatgctcgc taccaccagg      300

ccttcgccga ccgcgaccag tcggagcggc agcggcacga gagccagcag ctggccacag      360

agacccaggc gctggcgcag cgcacgcagc aagactccac gcgcacagtg ggcgagcgac      420

tgcaggacac gcacagctgg aagtcggagc tgcagcgtga gatggaggcg ctggctgcgg      480

agaccaactt gctcctggcc cagaagcaac ggctggagcg cgccctggac gccacagagg      540

tgcccttctc catcaccact gacaacctgc agtgccgtga gcgccgcgag caccccaacc      600

tcgtgcgcga ccatgtggaa acggagctgc tgaaggaagc cgagctcatc cggaacattc      660

aggagctgct gaagagaacc atcatgcaag cagtgagcca gatccgactg aaccgggagc      720

acaaggagac ctgcgagatg gactggtcag acaagatgga ggcctacaac atcgacgaga      780

cctgcgggcg ccaccacagc cagagcaccg aggtgcaggc tcatccgtac tccaccacct      840

tccaagagag cgcctccacc ccggagaccc gggccaagtt cacgcaggac aatctgtgcc      900

gtgcccagcg cgagcgcctg gcctcggcca acctgcgggt gctggtggac tgcatccttc      960

gcgacacctc cgaggacctg cggctccagt gcgacgccgt gaacctggcc ttcgggcgcc     1020

gctgtgagga gctggaggac gcgcggtaca agctgcatca ccacctgcac aagacactgc     1080

gggaaatcac agatcaggaa cacaacgtgg cggcactgaa gcaggccatc aaggacaaag     1140

aggcacctct gcacgtagcc cagacccggc tgtacctgcg ctcgcaccgg cccaacatgg     1200

agctgtgccg tgacgcagcc cagttcaggc tgttgagtga ggtggaggag ctgaacatgt     1260

ccctcacagc actgcgagag aagcttctag aagcggagca gtccctgcgc aacctcgagg     1320

acatccacat gagcctggag aaggacattg ccgccatgac caacagtctc ttcatcgacc     1380

gccagaagtg catggcccat cgtactcgct accccaccat cctgcagctg gctggctacc     1440

agtgagcagc ggcacggtgc ttccccccag tcccccaaat aaacagcgcg ttagctttct     1500

gcaca                                                                 1505


<210> 634
<211> 2336
<212> DNA
<213> Homo sapiens

<400> 634
gagctacaac agctgagaca gaaaagaggt aaggaagtgt tgggggctgg gacaaccagc       60

tccccaacaa ctcctaggtg tttaaagaag gaggcaggaa gacttgtgaa gatgggaact      120

atacaagagg caggaaaaaa gacagatgtt gggtggagca actgctacag aggtaaatat      180

gattaacttt acattccatc tttcgtctgc tcccaaactt aacagcaggt aatctgcttc      240

tagcaagtgg tgaaggtaag agaagcatct gtataggagg caagagatct gagtcctttt      300

gaaggcctat cctctgctct gtatctcaat tactgttctt catttcaatt attcttacct      360

actattcagt tcccttgatc ttttcttctt gggggctgtc ttagggtcag ggagattgca      420

gaagcaccag aactaggagc agccctgaga catggggagt tggagctgaa ggaggaatgg      480

caggatgaag aattccctag attgcttcct gaggaggctg gcacttctga agatcctgaa      540

gaccctaaag gagattcaca ggcagctgca ggtaccccca gcactttagc cctgtgtggc      600

cagcgcccca tgcgcaagcg tctttctgcc ccagagttgc ggctgagtct gactaagggg      660

cctggaaatg atggagcttc acccacccag tctgcacctt cctctcctga tggcagttct      720

gacctggaga tagacgaatt ggagacacct tcagactcgg agcagctgga cagtggacat      780

gaatttgaat gggaagatga actaccccgg gcagagggtc tgggcaccag tgagacagct      840

gaaaggctgg gccgaggttg tatgtgggat gtgactggag aagatggaca tcactggagg      900

gtgttccgaa tgggaccacg ggagcagcgc gtagacatga ctgtcattga gccctataag      960

aaagtcctgt ctcatggagg ttaccacggt gatggcctca atgctgtcat cctttttgct     1020

tcctgttatc tacccagaag cagcatcccc aactacacct atgtcatgga acacttgttt     1080

aggtatatgg tgggaactct ggagctgcta gtagctgaaa attacctgct tgttcatttg     1140

agtggaggca caagcagggc ccaagttcca cctctaagct ggatacgtca gtgttaccgt     1200

accctggatc ggcggctacg gaaaaacctg cgagccctgg tggttgtcca tgctacatgg     1260

tatgtgaaag catttctggc actgcttcgg cccttcatca gttccaaatt cacacgaaaa     1320

atccgttttc tggacagcct gggggagctg gcccaactca tatccctgga tcaagtccac     1380

atccctgaag ctgtcagaca gctggaccgg gatctccatg gctcaggagg gacatagcac     1440

aggactggat aaaaggcctt agaaccagtt agtgatctgc ctacacctga atccctgaaa     1500

catctgaact gttttgtaaa tcatcttatc cccaacctca gtaccaccgg atcttcactt     1560

ctcagtggga ttttgtcctt tgcatgaccc tactttcagc agggctttga ggctgggaaa     1620

ctgatctgct gggtgacttt cattccagtt gctgggacgg aaggctgaat gtagggtcat     1680

tttgtatggg atatgcagag ctctgggttt ttttgttttt tgttttttga gacggagtct     1740

cgctctgtcg ccaggctgga gtgcagtggt gcgatctcgg ctcactgcaa cctccgcctc     1800

ccggttcaag ccattcttct gcctcagcct cagcgagtag ctgagactac cggcgcacgc     1860

caccacgccc agctaattgt tttgtatttt tagtagagac ggggtttcac catgttggcc     1920

aggatggtct cgatctcttg acctcgtgat ctgcccgcct cggcctccca aagtgccgag     1980

attacaggtg tgagccaccg cgctcggcca gagctctggg ttttaatcct actttagctg     2040

tagaaccttg ggcaaataac ttcatctttt tgggtcctaa ttttcctcct gtctaactgg     2100

agggactgtg atccttccac cttggatgga agaggcttac ctgacagcca gcctgcctgc     2160

tgggagccag gagagtcagc tcattaaatc ttgaagaacc gctgtatgcc ctttttcctt     2220

ctaagtcatg tctgctgcct gtgagcctgg gaaggagtgc tttcaaaacc tgtatttttg     2280

ccctctttag taaatttaga actgtagagg ctaataaact gcgatgagac atttaa         2336


<210> 635
<211> 2626
<212> DNA
<213> Homo sapiens

<400> 635
cctcgatccc ctcgccgcgg tcccatggag gaggaggcga gccgcagcgc cgcggcgacg       60

aacccaggga gtcggcttac ccgctggccg cctcctgaca agcgggaggg atccgcggtg      120

gacccaggga agcggaggag cctggcggcc accccctctt cctcacttcc ctgtactctc      180

atcgctctcg gcctccgaca cgaaaaggaa gcaaatgagc tgatggaaga tctgtttgaa      240

actttccaag atgagatggg attctccaac atggaagatg atggcccaga agaggaggag      300

cgtgtggctg agcctcaagc taactttaac acccctcaag ctctacggtt tgaggaacta      360

ctggccaacc tactaaatga acaacatcag atagcgaagg aactatttga acagctgaag      420

atgaagaaac cttcagccaa acagcagaag gaggtagaga aggttaaacc ccagtgtaag      480

gaagttcatc agaccctgat tctggaccca gcacaaagga agagactcca gcagcagatg      540

cagcagcatg ttcagctctt gacacaaatc caccttcttg ccacctgcaa ccccaatctc      600

aatccggagg ccagtagcac caggatatgt cttaaagagc tgggaacctt tgctcaaagc      660

tccatcgccc ttcaccatca gtacaacccc aagtttcaga ccctgttcca accctgtaac      720

ttgatgggag ctatgcagct gattgaagac ttcagcacac atgtcagcat tgactgcagc      780

cctcataaaa ctgtcaagaa gactgccaat gaatttccct gtttgccaaa gcaagtggct      840

tggatcctgg ccacaagcaa ggttttcatg tatccagagt tacttccagt gtgttccctg      900

aaggcaaaga atccccagga taagatcctc ttcaccaagg ctgaggacaa caagtacctt      960

ctaacctgca agactgcccg ccaactgaca gtgagaatca agaacctcaa catgaacaga     1020

gctcctgaca acatcattaa attttataag aagaccaaac agctgccagt cctaggaaaa     1080

tgctgtgaag agatccagcc acatcagtgg aagccaccta tagagagaga agaacaccgg     1140

ctcccattct ggttaaaggc cagtctgcca tccatccagg aagaactgcg gcacatggct     1200

gatggtgcta gagaggtagg aaatatgact ggaaccactg agatcaactc agatcaaggc     1260

ctagaaaaag acaactcaga gttggggagt gaaactcggt acccactgct attgcctaag     1320

ggtgtagtcc tgaaactgaa gccagttgcc gaccgtttcc ccaagaaggc ttggagacag     1380

aagcgttcat cagtcctgaa acccctcctt atccaaccca gcccctctct ccagcccagc     1440

ttcaaccctg ggaaaacacc agcccaatca actcattcag aagcccctcc gagcaaaatg     1500

gtgctccgga ttcctcaccc aatacagcca gccactgttt tacagacagt tccaggtgtc     1560

cctccactgg gggtcagtgg aggtgagagt tttgagtctc ctgcagcact gcctgctatg     1620

ccccctgagg ccaggacaag cttccctctg tctgagtccc agactttgct ctcttctgcc     1680

cctgtgccca aggtaatgat gccctcccct gcctcttcca tgtttcgaaa gccatatgtg     1740

agacggagac cctcaaaaag aaggggagcc agggcctttc gctgtatcaa acctgcccct     1800

gttatccacc ctgcatctgt tatcttcact gttcctgcta ccactgtgaa gattgtgagc     1860

cttggcggtg gctgtaacat gatccagcct gtcaatgcgg ctgtggccca gagtccccag     1920

actattccca tcgccaccct cttggttaac cctacttcct tcccctgtcc attgaaccag     1980

ccccttgtgg cctcctctgt ctcaccctta attgtttctg gcaattctgt gaatcttcct     2040

ataccatcca cccctgaaga taaggcccac atgaatgtgg acattgcttg tgctgtggct     2100

gatggggaaa atgcctttca gggcctagaa cccaaattag agccccagga actatctcct     2160

ctctctgcta ctgttttccc caaagtggaa catagcccag ggcctccacc agtcgataaa     2220

cagtgccaag aaggattgtc agagaacagt gcctatcgct ggaccgttgt gaaaacagag     2280

gagggaaggc aagctctgga gccgctccct cagggcatcc aggagtctct aaacaactct     2340

tcccctgggg atttagagga agttgtcaag atggaacctg aagatgctac agaggaaatc     2400

agtggatttc tttgagctag gagaataaga gtctggagac tgggagcctt cacttcggcc     2460

tccgattggt ggcgcatagg gtgtaaccaa taggaaaccc ctaaagggta cttaaacccc     2520

agattttgca actggggctc ttgagcagct tgctttagcc tgctcccact ctgtggaata     2580

tacttttgct tcaataaatc tgtgctttta ttgcttcatt gtttca                    2626


<210> 636
<211> 1914
<212> DNA
<213> Homo sapiens

<400> 636
agaccccctg gcccgtgcgc ttcgcaggcc agagcccctc tctcaccccc agcctaggag       60

ctccaagctc ctcaggccaa gggacggatt ccctggcgtt tagccccatc tcttctggct      120

gcctgcatac gttgcctgac ttataattct tctccacccg cctctccctc cggtctcttt      180

cggctccctt tcttacaatt ttactcgcta gaactggtga gaagttcaga ggacaaaggc      240

gctcagaggt gtggaatgga cggcggacca cacatgggca cttcctggga cacatccgaa      300

ctgcctcagg gccatcaggc ccggctaagg acccggagtc tgcggttgcc tagaaacgac      360

gctagctgcc cacccctctt agttttccgc ctccgacttc cctaagggca tttccggttc      420

cggctgcggg ccggtgaaga tatggcggcg tctgcgtctg cagctgcagg ggaggaggac      480

tgggtccttc cctctgaagt tgaagtattg gagtccatct atctagatga actacaggtg      540

attaaaggaa atggcagaac ttcaccatgg gagatctaca tcactttgca tcctgccact      600

gcagaggacc aggattcaca gtatgtctgc ttcactctgg tgcttcaggt cccagcagag      660

tatccccatg aggtgccaca gatctctatc cgaaatcccc gaggactttc agatgaacag      720

atccacacga tcttacaggt gctgggccac gtggccaagg ctgggctggg cactgccatg      780

ctgtatgaac tcattgagaa agggaaggaa attctcacag ataacaacat ccctcatggc      840

cagtgtgtca tctgcctcta tggtttccag gagaaggagg cctttaccaa aacaccctgt      900

taccactact tccactgcca ctgccttgct cggtacatcc agcacatgga gcaagagctg      960

aaggcacaag gacaggagca ggaacaggaa cggcagcatg ctacaaccaa acagaaggca     1020

gtcggtgtgc agtgtccagt gtgcagagag cccctcgtgt atgatcttgc ctcactgaaa     1080

gcagcccctg aaccccaaca gcccatggag ctgtaccagc ccagtgcaga gagcttgcgc     1140

cagcaagaag aacgcaagcg gctctaccag aggcagcagg agcggggggg aatcattgac     1200

cttgaggctg agcgaaaccg atacttcatc agccttcagc agcctcctgc ccctgcggaa     1260

cctgagtcag ctgtagatgt ctccaaagga tcccaaccac ccagcaccct tgcagcagaa     1320

ctatccacct caccagccgt ccaatccact ttgccacctc ctctgcctgt ggcgacccag     1380

cacatatgtg agaagattcc agggaccagg tcaaatcagc aaaggttggg cgaaacccag     1440

aaagctatgc tagatccccc caagcccagt cgaggtccct ggcgacagcc cgaacggagg     1500

cacccaaagg gaggggagtg ccacgcccct aaaggtaccc gtgacaccca ggaactgcca     1560

cctcctgagg ggcccctcaa ggagcccatg gacctaaagc cagaacccca tagccaagga     1620

gttgaaggtc ctccacaaga gaaggggcct ggcagctggc aggggccccc accccgcagg     1680

actcgggact gtgttcgctg ggagcgctct aaaggccgga cacccggttc ttcctaccct     1740

cgcctgcctc ggggccaggg agcataccgg cctggtactc ggagggagtc cctgggcctg     1800

gaatctaagg atggttccta gcaggacttg gtggggggaa cagggaattg gggatgggag     1860

ggaggcaata aagatatttg gccttctttg gctttctttg cttagcagcg ccta           1914


<210> 637
<211> 6395
<212> DNA
<213> Homo sapiens

<400> 637
atgtctgaga gccccaagga cgagggctcc gaagagtgtc tgtttctgca gcgcctatgg       60

gagtgggggg cagtgggggg aactcaggga agctgcctac aacttgaggc cttccccagg      120

ctggaggagg aggacaggga aggccgaggg gagctgtcct ccggctgcca tcaccctgat      180

gaggcggccc tgccccgggc tgtggtctcc gcaggggctg gcaaccttgc ctttgtccag      240

ctctctccgt ggccaggcct gccatctgcc tgcccacact cctccccggc aaagcccctt      300

gcaaatgctt gctttgggga ctggcagctt tcgcctctga atcaggacct agcatcagta      360

ctctggggag ggggtccagg tgccaaccct gtgagtccct ccctgtcccc tgacgctgag      420

aaggccctgc caacccccac catgtgtgag gtgatgccca caatcaatga gggggaccgc      480

ctgggtcccc ctcatggcgc cgatgctgac gccaacttcg agcagctgat ggtgaacatg      540

ctggacgagc gggagaagtt gctggagtct cttcgggaga gtcaggagac cttggcggcc      600

acacagagcc ggctccagga tgccatacac gagcgggacc agctccagcg ccaccttaac      660

tccgccctcc cccaggaatt tgccacctta acccgggagc tgagcatgtg tcgggagcag      720

cttctagagc gggaggaaga gatatcagaa ctgaaagcag aacggaataa cacacggctg      780

cttctggaac atctggagtg cctggtgtcc cgccatgaac ggtcactgcg gatgactgtg      840

gtgaagcgcc aggcccagtc accttcgggg gtctccagtg aggtggaggt gctgaaggcc      900

ctcaagtcac tgtttgagca ccacaaggcc ctggatgaga aggtgcgaga gcggctccgg      960

gcagcgctgg agcgagtcac caccttggag gagcagctgg caggtgccca ccagcaggtg     1020

tctgccctgc agcagggggc aggggtgcgg gatggagcgg cagaagagga ggggactgtg     1080

gagctggggc cgaaacgcct gtggaaggag gatacgggcc gggtagagga gctgcaggag     1140

ctcctggaga agcagaactt tgagttgagc caggcccggg agcgactggt caccctaaca     1200

acaaccgtga ctgaactcga ggaggacctg ggcacggccc gccgggacct catcaagtcg     1260

gaggagctga gcagcaagca tcagcgggac ctccgggagg ctctggccca gaaggaggac     1320

atggaagagc ggattactac actggagaag cgctacctgg ctgctcagcg tgaggcaaca     1380

tccatccatg acctcaatga caagctggag aatgagctgg ccaacaagga gtccctgcac     1440

cgccagtgtg aggagaaggc ccgacacctg caggagctgc tggaggtggc agagcagaag     1500

ctgcagcaga cgatgcgcaa ggcagagacg ctgccagagg tggaggctga gctggcccag     1560

agaattgcag ccctcaccaa ggctgaagaa cggcatggca acattgagga gcacctgcgg     1620

cagctggagg gacagctgga ggagaagaac caggagctgg cacggacggc tgtgcaggtg     1680

cgccagcggg aaaagatgaa tgaggaccac aacaagcggc tgtcggacac agtggaccgg     1740

ctgctcagcg agtccaacga gcgtctgcag ctccacctga aggagcgcat ggctgccctg     1800

gaggagaaga acacgttgat ccaggagttg gagagctccc agcggcagat tgaggagcag     1860

caccaccaca agggccgcct gtctgaagag attgagaagc tgcgccaaga ggtggaccag     1920

ctgaagggcc gaggggggcc gtttgtggat ggcgtccact ccaggtcgca catgggcagt     1980

gcagcagacg tgcggttctc cctgggcaca accacacacg cacccccagg cgtgcatcgc     2040

cgctactcgg cattgaggga agagtctgcc aaggactggg agacttctcc actgcctggg     2100

atgctggccc cggcagctgg ccctgccttt gacagtgacc ctgagatctc cgacgtggat     2160

gaggatgagc cagggggtct ggtgggctct gcggatgttg tctcccccag cggccactca     2220

gatgcccaga ccctggccat gatgctgcag gagcagctgg atgccatcaa tgaggaaatc     2280

aggatgattc aggaagagaa ggagtccacg gagctccgcg cggaggagat tgagacgcgt     2340

gtaaccagtg gcagcatgga agccctaaac ctgaagcagc tgcgcaagcg tggttccatc     2400

cccacctctc tgacggccct gtccctggcc agcgcgtccc caccactcag cggccgctcc     2460

acacctaagc tcacctcccg cagtgctgcc caggacctgg accgaatggg ggtcatgacc     2520

ctgcccagtg acttaagaaa gcataggagg aagctgctgt cgccagtgtc tcgggaagag     2580

aaccgagagg ataaagccac cataaaatgt gagacttctc ctccttcctc acccaggacg     2640

ctgcggctag agaagcttgg ccacccagcc ctgagccagg aagaaggcaa gagtgccttg     2700

gaggatcagg gcagcaaccc cagcagcagc aacagcagcc aggactccct gcacaagggc     2760

gccaagcgca agggcatcaa gtcgtccatt ggccgcctgt ttgggaagaa ggagaagggc     2820

aggctgatcc agctgagtcg ggatggagcc acaggccatg ttctgctaac agactccgaa     2880

ttcagtatgc aggagcctat ggtgcctgcc aagctgggga cccaggcaga gaaggaccgg     2940

cggctaaaga agaaacacca gctgcttgaa gatgcccgca ggaaaggaat gccctttgcc     3000

cagtgggatg gtcctactgt ggtctcctgg ttggagctct gggtggggat gcctgcctgg     3060

tatgtggcag cctgccgggc caacgtcaag agtggtgcca tcatgtccgc tctgtcggac     3120

acagagatcc agcgggagat cggcatcagc aatgccctgc accggctcaa gctccgcctg     3180

gccattcagg agatggtgtc attgaccagc ccctctgccc cacccacctc caggacttct     3240

tctgggaatg tctgggtcac ccatgaagag atggaaactc tggaaacatc tactaaaaca     3300

accctggcct atggggacat gaaccatgag tggattggga atgaatggct acccagcctg     3360

gggctcccgc agtaccgcag ctacttcatg gagtgcctgg tggacgcccg catgctggac     3420

cacctcacca agaaggacct gcgggtccac ctgaagatgg tggacagctt ccatcgaacc     3480

agtcttcagt atggcatcat gtgtctgaag aggctgaatt atgaccggaa ggagctggag     3540

aagaggcgag aggagagcca gcatgagatc aaggatgtgt tagtctggac caacgaccag     3600

gtggttcatt gggtccagtc tattgggctc cgggactacg caggaaacct gcatgagagt     3660

ggtgtgcatg gagccttgct ggccctggac gagaacttcg accacaacac actggccctg     3720

atcctccaga tccccacaca gaacacccag gcacgccaag tgatggaaag agagttcaat     3780

aacctgttgg ccttgggcac agaccggaag ctggatgacg gggatgacaa ggtgtttcgc     3840

cgcgcgccct cctggaggaa gcgcttccgg ccgcgggagc accacggtcg cggcggcatg     3900

ctcagcgctt ccgcggagac cctcccggcg ggcttccgtg tgtccaccct ggggaccctg     3960

cagcccccac cggccccgcc aaagaagatc atgcctgaag ctcactccca ctatctctac     4020

ggacacatgc tctccgcctt ccgggactag ccatggcccc cagggctggc ttcctccttc     4080

tgggtttcac aggctcctct ggccctgacc cctcttgctc gttccccttc cttccgcagc     4140

tcctagtctc gtccgtgact ttccggttgc cctggatctc agaatatatt cgtccacccc     4200

ctcggcaccc cattaccccg agtcccaccg tgtgtccgtt gtaagtccgg tggatgtggc     4260

tggggtttcc tggtattgtg gaggcaccca ggttgtccat gcttgggatt ctgggggaag     4320

gagagaaggg cagctcaggg tggatgtgaa gccacccttc ctcttctgga cccagcctgg     4380

tctgcactgc aacctccacc aggaccagga tcctgggcca caggctggga tggtccttcc     4440

aagaaagggt catttcagac gcagccctgc ttgggctatt caatcttagg gtgtctatcc     4500

acgtctggct gtgccaaatg gtctggcagc tggttttggc atccccagca tcaccactct     4560

cccaacccat caccgtgact gcagttcctg cccccattct cttggggtca gggaggggct     4620

gggaagggct actgaaggcc ccattctccc acaggatggt gaggctggga ggaggaagac     4680

tgaggtagag attccaggcc ctggcataag ctgaatccca aatttgagtt tgggaagaac     4740

cagagagaaa tggatccctg agctctgagc caagggtgag gatggggaaa ctctaagctc     4800

ccacctaata agaagcatag gcagaccagc cagagggaga gccaatggcc tctggtagcc     4860

ttaagcccaa agggcagtgg gaatgtcccc tgccccaacc atcgggtgga gctcctgctg     4920

ggctatgggg aagggaggtt gtgcggatct tgactctagg gcagaacaga tctaaccatg     4980

cattgctagc tctgctccca gcatcccttc cccttctctc ctcctctgcc tcacttcttt     5040

agtaatccca accctataaa aatgaaccta atgggtggat tgaatataca ttgagcccaa     5100

agtcaagttt ggggaaaagg cagactaagg cctcctttct ctgacctccc aggaagaaaa     5160

tagcttctcc tacagtgatt catgtcccag gtccaggaaa tccaatgttg gtgaaggcag     5220

ccactctctt gcttgtcccc aaatcaccta accctcatcc agggctattt tggtgggcag     5280

ggactgcctc ctcccggaat tcctaagatc cgcccagctg ccaccatttt cattgctttc     5340

cccagcagca tgatgggaac ccaagctgag ggatacaggt cctgatttgg taggaatatt     5400

attcccaaga aatacccgct cctcacctac tccctcatcc taccaaggtg cctgaaaatg     5460

ttcaagactt atgttcaggg tgggatgatg gaaccgaggg cttcatcaaa gtgagaggaa     5520

aggaaaagca tctggcatgt gtttcttgga taggggccag tgcagtgcca tcctacaggt     5580

ggctggagca gctgctttgc aacctgatca ccttgagttc tgagcaggga ctaggcttgc     5640

aggtgagata atgggccagg gcacccagtc cagaaggagc aatggcacct gggcagtgcc     5700

agggcttaaa gcccgctgct ccttttcggt agaggagagg cccatcactg gtgtggtggg     5760

gtgggctctc ccttaggctt gggcaaggca gccacctgcc cttgctctcc cttagtgttc     5820

cctggcctcc ctgccatcag gttgctggga gtggagatgg agggattatt gagcagaaaa     5880

tgagttggat ggagataaac agctcccatc cctgggtaat ggatggtaag atgatggaga     5940

ttcctaagat tggtggagtt gggcaatgca tagccatctg actccttcag ggtgctcttg     6000

atgggctggc tgtaagggag actcagtccc agcctctccc ctctacaact cctgccactg     6060

ttggccatgt cgtaaggcag cagctgtgcc aggatagctg ggtccattca gagcaccttg     6120

agaagtgttg cagggaggtg ttaagaagag aactctgtgc aaacagtgat ggaaggctgt     6180

tgtcttggtg tatcccttgc ctcatagtca atatattttt tttttggcga gtcaccagtg     6240

acccgagccc tccacaccag cctcctgtat ctcatcaggt cccttctcag tactgtattt     6300

gctcagtgca tcaggaatgg gtgtatgggt gtgtgtgggt gggtgtgagt gtgggtgtgt     6360

acgtaccaat aaacaacctg gttttaagac aatgt                                6395


<210> 638
<211> 2190
<212> DNA
<213> Homo sapiens

<400> 638
ctcgcgtgcg tccgtatccg ggagcagcca ctaggtaact gtagaggcca ctgcaattaa       60

tcggcttgaa cagccaggag cggaaacccg agagtcagtt caaccacagc cacccgcgtg      120

tgcccgcgga aagccgatgg cctactctcg tccggcagcg cactggtttc ctgggttacc      180

ggcctcagcg ctcctcccgc tttcttttcc gggaggcgac aatctgacgc tctcagcgcg      240

tgacgcagca cgctttgata taaatgcaga ccgcgcggcc gtagcttcct ctctgctctc      300

gcggccgact cgcaagatgg cgccgcagaa agacaggaag cccaagaggt caacctggag      360

gtttaatttg gaccttactc atccagtaga agatggaatt tttgattctg gaaattttga      420

gcaatttcta cgggagaagg ttaaagtcaa tggcaaaact ggaaatctcg ggaatgttgt      480

tcacattgaa cgcttcaaga ataaaatcac agttgtttct gagaaacagt tctctaaaag      540

gtatttgaaa taccttacca agaaatacct taagaagaac aatcttcgtg attggcttcg      600

agtggttgca tctgacaagg agacctacga acttcgttac ttccagatta gtcaagatga      660

agatgaatca gagtcggagg actaggcaaa ggctcccctt acagggcttt gcttattaat      720

aaaataaatg aagtatacat gagaaatacc aagaaattgg cttttagttt atcagtgaat      780

aaaaaatatt atactcttga acttttgtct catttttttg agtatgctgt ttatatgatt      840

ttgatttccc tctgataact atcaacagta tttaaatagc ttatagctgg tataattttt      900

tcccacgatt tccaaaatct tttatgtact caggtaaaag tagcgttata taggaaatct      960

tttttttaga cactctcgtt ctgtcaccca ggctggagtg cagtgactca gcttcctaaa     1020

tagctggaat tacaggtgtg agccaccatg cccggctaat tttttgtact tttagtagag     1080

tagggtttgg ccatgttggc caggctggtt tcaaactcct gacctcaagt gatctaccca     1140

cctcggcttc ccaaagtgct gattatagct gtgaaccacc atgcccggcc aggaaatctt     1200

actgtagaac aattttttat atagctgtat aaaatgtata tgattgtctt gacagtctca     1260

aatactgttt ttaatagctt gtaaatgtaa tctcaagtgc ttagaacagt tcttacatat     1320

aagttgctct gtagtttgct cttatagtta gcccaaagac tctgggtgtg aggcctgctg     1380

taaaccaatg ttaaactgct tattagaaag ccctaaccac ctgctttgta ggcaccagaa     1440

actcaaaacc aaatctcaac tcagctacag aatctactgt ggtccttgtc tgaaaaaatt     1500

agttcactcg gttggaatct tgtctcagag catcctcatc tctttctcaa aagcccctac     1560

cccaacaccg gcgtgttggt tgtctattga aacttacaag tggatggacc ctttctcccg     1620

aataaactgg cctttgaaag ctctaatcga aatggtttgg caaaatccat actgcaggag     1680

attagggagg acaagaatga tgtgcctttt tgtactgctg agcctgatgg tggtgccact     1740

acttcaggta cttagatgag tcttgatgct aatagaattg tgtcgccaaa catatctgga     1800

cagttacaac ctaatctatg cattaattgg tttgggaatt gcttgaaatt attgtttaat     1860

tcaatgtttt aattcgtttt cctaaaaatt taagtgcccc catcatcgtg caatacctca     1920

gtgcagcaac tccttgattc ttggatgact gaacttccta acttggctct gccccattgt     1980

tcccattttt catgtttttc acaaatagtt aaccaggtac ctactactgt gcaccgctgc     2040

agagcattga ggatgtatgt gatgagtaaa aacacccagc ctgctctgct gtgttagtat     2100

tatgacggaa actgatcaaa tcacatgtga acaaatttac tgctacaaaa gggagggctt     2160

aataaaagga atttcatctg ggaaggcaaa                                      2190


<210> 639
<211> 4306
<212> DNA
<213> Homo sapiens

<400> 639
gagatgacaa tagggagaat ggagaacgtg gaggtcttca ccgctgaggg caaaggaagg       60

ggtctgaagg ccaccaagga gttctgggct gcagatatca tctttgctga gcgggcttat      120

tccgcagtgg tttttgacag ccttgttaat tttgtgtgcc acacctgctt caagaggcag      180

gagaagctcc atcgctgtgg gcagtgcaag tttgcccatt actgcgaccg cacctgccag      240

aaggatgctt ggctgaacca caagaatgaa tgttcggcca tcaagagata tgggaaggtg      300

cccaatgaga acatcaggct ggcggcgcgc atcatgtggc gggtggagag agaaggcacc      360

gggctcacgg agggctgcct ggtgtccgtg gacgacttgc agaaccacgt ggagcacttt      420

ggggaggagg agcagaagga cctgcgggtg gacgtggaca cattcttgca gtactggccg      480

ccgcagagcc agcagttcag catgcagtac atctcgcaca tcttcggagt gattaactgc      540

aacggtttta ctctcagtga tcagagaggc ctgcaggccg tgggcgtagg catcttcccc      600

aacctgggcc tggtgaacca tgactgttgg cccaactgta ctgtcatatt taacaatggc      660

aaaattgagc tccgggccct aggcaagatc tcagaaggag aggagctgac tgtgtcctat      720

attgacttcc tcaacgttag tgaagaacgc aagaggcagc tgaagaagca gtactacttt      780

gactgcacat gtgaacactg ccagaaaaaa ctgaaggatg acctcttcct gggggtgaaa      840

gacaacccca agccctctca ggaagtggtg aaggagatga tacaattctc caaggataca      900

ttggaaaaga tagacaaggc tcgttccgag ggtttgtatc atgaggttgt gaaattatgc      960

cgggagtgcc tggagaagca ggagccagtg tttgctgaca ccaacatcta catgctgcgg     1020

atgctgagca ttgtttcgga ggtcctttcc tacctccagg cctttgagga ggcctcgttc     1080

tatgccagga ggatggtgga cggctatatg aagctctacc accccaacaa tgcccaactg     1140

ggcatggccg tgatgcgggc agggctgacc aactggcatg ctggtaacat tgaggtgggg     1200

cacgggatga tctgcaaagc ctatgccatt ctcctggtga cacacggacc ctcccacccc     1260

atcactaagg acttagaggc catgcgggtg cagacggaga tggagctacg catgttccgc     1320

cagaacgaat tcatgtacta caagatgcgc gaggctgccc tgaacaacca gcccatgcag     1380

gtcatggccg agcccagcaa tgagccatcc ccagctctgt tccacaagaa gcaatgagga     1440

ctgcccagtg gaggaggggc gatgtggctg gggagctagg gagagactct ggaggtggtg     1500

ggtctctcgg gagaccccta atgaggaagt tgaggtaatg cttaacattg ttgctgtgag     1560

aatttactgc cctatgtttc ccagagccat tttggctcaa ttcaagtcta ttcaattcaa     1620

gttaactcta gcccagccca gatcaactcc tcctacaaat attattggat gataggccct     1680

agaacccaat aaaggagctc caaatgtcgt tgggtgggga agcaaaatgt agagaaacat     1740

ttaaagcaca ctgtaataat aaatgcaatt ataaactata tggaggaggg tgcagaggag     1800

ggaatgtgtc tggtgtgtga tgtgtgtgtg tgcagtgggg gtatcacaga gagtatgaca     1860

tctgagttga gggtagcagg tgcctggagt ctcaggtggc tgctcaccca tctgtgcagg     1920

tgtctctggg gctgctggtc tcacctgtgg tctgcagtag acacaattgg ctgagcagga     1980

tatgtgatac tgtgtggttg gtgtggagtt ttgaagaagg ggctgtgttt gggccacgta     2040

ggctctactc agagacctga aaccacttca gaatggtgca tatgtcgaaa gagctggctg     2100

ggggccttgc ccaaaccaac tgaggtctta aagtccaggg aaaaaaagtc tgggttccaa     2160

ctagaattct agaaatattt ctagaacaca cagagaggga ataagtccct ctatcaccct     2220

tattaccaag ccttgtggtt ccctgtgatt ttagataatg tctgatattt ttctggctat     2280

ttgcctagta ggatttaaaa aatattttca aagtgaagct gagagagaat cttggaaaca     2340

cacatacctg ttgatcatgg gccctgcaga attggccctt gggggcttta tttggttaca     2400

tgtgcctggg tggtctttac cagcttagac tctatcatgg gcccccatga agctccattc     2460

tcaatactga ataattatta cttcccttgt tgagtttctt tttctgtcat gccctggggg     2520

cttctgctct tctcaccaga aagaacattt gaatctggat tcttgtacac ctgggttaga     2580

ccctgttcag aggtgtggcc aatttatccc gatctcctgg aaggctgttg tgatttccat     2640

ctaagaaatg agggtcttga gaatcaacca gtcccaagat tagcctgtta tcctgttatc     2700

tactgagacc ccaaatttct caccaatgtt ttgggagatc ctggaaaaga tcccttcagt     2760

ttggggtgtc accaagactt ctacacaacc caggactacc attgacctca gagctgtacc     2820

ccacatcttg aagtaaattg atcccaccag gtcccacgtt tgttatctct gcctaaatgt     2880

tagcttctcc atcctcacca catgatgacc tgctgtgtcc ctctgagcac tacccagtgg     2940

ctgaaaactc tgcaaatggg ccacactttt gcaaaatact tgtatctgac acttaggtct     3000

tgtttgaaga atttcctttc tggaaggttt tacaagaaga ctgatagtct ttcaagcccc     3060

cacatcacag gcttagggac ggcactaact ttctcccagg gatctaactg gctagttcaa     3120

attatcactc ttttaccttc atataaaatg tctcccccaa acctttttcc cttctttgtc     3180

attgttatct gctaagcccc tggtcatttc cccatattcg tagtcttttt ttccatccta     3240

tctttctaat atttgttgtc tttaacaaac tgtgttctgt gtctgtgctc ctccttccct     3300

ctcagaccac tggaatgcaa gtccttcttc cctttggaat gtactctgga tcccttcccc     3360

tgctttgacc cccagacttt gctccatcta ttattgcttc tccatcctgg atccttgaca     3420

tttgtcaccc cactggcctt ctcaggtgca atcagtaaaa atgctgagaa ctcttggatc     3480

ttaatcttca tgactgagtt ttttttagtt gtatagttat catctgcctt tcttcacttt     3540

gcatttcttc ttgaatccat tgcagattga cttccactcc cactccttca ctaaaagggc     3600

tcttaccaag atcaaatcta atgggtacat tttagttcct atgtgatttg gcctttcgat     3660

gtcaatcatc actcccagcc attgattttg gtgacccact tccctgtgat gatcttctga     3720

tctagtttct caggttcctt cgctggtcct ttttctttcc ctgcccctga catattgaca     3780

tttcctggag ttggttttgt ccttgattca ttctcatgtc attctgcaca cagtctctgc     3840

atgaactcag gcagaccctt catttaatga ccaccttagg gctgatgatt ctcaaatctg     3900

tattccccga tcttgcattt gagctccagc cccactcatc ctctcggatg ttctgcaggc     3960

ccagcaaact catcatgtcc aaagtgaaac tttttctctt tcctgtctcc tctcctctga     4020

tctgttcttt cttggaacac cacccaagaa cgtcacctcc tccatcagat tgtgagctcc     4080

tggagggcag gagctgtgtc cttctattca tcttcctatc cccagaacct tgcacagatc     4140

ctggaatgtg gtaggtgctc agtaaatgtg tgttgaataa atgaatgaat gaatgaacaa     4200

atgaatgaat ttgcttactt caaggcaaaa gaaccatgaa actgtatttt gagtttctat     4260

gttatagcag tcagcaaatc ctattaaata ctttgtgttt ccaagc                    4306


<210> 640
<211> 6659
<212> DNA
<213> Homo sapiens

<400> 640
ccggcggcgc gggcgagggt gggaatcttt ttcgggctcc cgggggcgga gggaagggag       60

cgcgcgtgcg cgcgcccggc cggccgtcgc cgcggtgacc gtcctcggag tccgtcggct      120

cgcgccccgc ccccgtcgcc ccctcccctg tcgcgcgctg gggctgtttc tcgctccttc      180

cgagttaccg ccgccgtcgc cgccgctcct cctctcccgg tcctgggttt ccttggcgct      240

gcggccgccg ctccctctgc gacctgtatg aggaggagga ggaggaggat gtgaagatgg      300

cggagctgca gatgctgctg gaagaggaaa tcccgggggg ccgccgggcc ctcttcgaca      360

gctacacaaa tctggaacgg gtggccgatt actgcgagaa caactacata cagtcagcag      420

ataagcagag agccctagaa gaaaccaaag cctacaccac ccaatcctta gcaagtgttg      480

cctatctgat aaacaccttg gccaacaatg tcctgcagat gctggatatc caggcatccc      540

agctacgaag gatggaatct tcaatcaatc atatttcaca aacagttgat attcataaag      600

agaaagttgc aagaagagaa attggtattt tgactaccaa taaaaacact tcaaggacac      660

ataagattat tgctccagcc aaccttgaac gaccagttcg ttatattaga aaacctattg      720

actatacaat tctagatgat attggacatg gagtaaagtg gttgcttaga tttaaggtga      780

gtacccagaa catgaagatg ggtgggctgc cgcgtacaac acctccaact cagaagcccc      840

ctagtccccc tatgtcaggg aaagggacac ttgggcggca ctccccctat cgcacactgg      900

agccagtgcg tcctccagtg gtaccaaatg attacgtacc tagcccaacc cgtaatatgg      960

ctccctcgca gcagagccct gtgaggacag cttctgtgaa tcaaagaaat cgaacttaca     1020

gcagcagtgg gagtagtgga gggagccacc caagtagtcg gagcagcagt cgagagaaca     1080

gtggaagtgg tagtgtgggg gttcctattg ctgttcctac tccatctcct cccagtgtct     1140

ttccagcccc tgctggctct gctggcactc ctccccttcc tgctacttct gcatctgccc     1200

ctgctcctct tgttcctgct actgtccctt cctccactgc cccagacgct gctgctgggg     1260

gtgcccagac ccttgctgat ggcttcactt ctccaactcc ccctgttgtt tcttccactc     1320

cccctacagg tcatcctgta cagttctaca gcatgaatag gcctgcctct cgccatactc     1380

ccccaacaat agggggctcg ttgccctata gacgccctcc ttccattact tcacaaacaa     1440

gccttcagaa tcagatgaat ggaggacctt tttatagcca gaatccagtt tcagatacac     1500

cacctccacc gccacctgtg gaagaaccag tctttgatga gtctccccca cctcctcctc     1560

ctccagaaga ttacgaagag gaggaagctg ctgtggttga gtatagtgat ccttatgctg     1620

aagaggaccc accgtgggct ccacgttctt acttggaaaa ggttgtggca atttatgact     1680

atacaaaaga caaggaagat gagctgtcct ttcaggaagg agccattatt tatgtcatca     1740

agaagaatga cgatggttgg tatgagggag ttatgaatgg agtgactggg ctttttcctg     1800

ggaattacgt tgagtctatc atgcattatt ctgagtaaag ctcagcaggg ctgtgcttgc     1860

ctcacaggaa tagtcaggtc ttcccagatt atctgaaggc cctggggatt ccactccagt     1920

aaagtagaat gaaggataca aatgataaaa attacacttt tttttttggt ttattcccca     1980

gtattaaaaa caaagcaagc tgagtctgaa caaatggatc tttctgccat catttgtaca     2040

atgctgagct gtctggattg aaataaaatg accattttta tgtatgtcaa aggtataaca     2100

gcataactgt gtagccaaaa caaaatcaga ttaagactga ttcagaaaaa tctgggatct     2160

ttctcaggaa tactgtatac ccttgggatt tctcctcctg cagaatctgt ggcattggat     2220

gttcttcatt gcctgtgcta aggggttaac ctcatggccc agtgggtacc ctagcccctt     2280

cttttcttcc acttgtatga agaggaggga accaacattt aaataccaca cttaaccatt     2340

tttacaatta tttcagatgg cttttttcct ctgtgacact gtaaattctg cattctctca     2400

gcacttgagt gcaccaaacg agtgaatgct gaactcactt gcatcccttc atgtttctgt     2460

ttgtggatta taaggatgat gaaatgtgaa agtctcccaa cactctgagg gtggtgaacg     2520

attgccaccc gtttgatttt aatgtgctgc tgcatgagac tgcattgttg ctaatggcca     2580

gtgtacccag atgtgaagtg tggtaggctg gttcatatgt ggaggtgggt gtgtgaagct     2640

agacacgaag gtccctaagg ttctgaagag acttgaactg tggaaatgct cttagcaggc     2700

atcccgaacc cctgcttcgg tgctgttttg aggagtagga tcttggagtt cagaccaact     2760

atgactatca tttccttcac tatctagaaa aacgctattc tactttggaa gagaatagta     2820

gttattttca agtctcctga cagtcactgg gagtacaagg tttgctaatg tgctctctgg     2880

acgttattaa tggccagtat tagttgctgc tgtattactg actcgcttag ctgtagaaag     2940

ggtaatactc tcctgatttt gtatgattgg actcttaagt agctgctgtt agtcagaatt     3000

aaaacccatc tcagactaag aatataatga ataagattaa taggccaaaa tatgtatcta     3060

atcacattga taaaaattaa tataactgac acaataaaac acatttcccc catctgtaca     3120

ataaatacag cttcaaattc agtggagtct gtagggcaga taactttaat catcactact     3180

gtagtcagta taagaaatgc tgaaaaaaat ccaggagggc ttgtctcttt gtgggtggtc     3240

actgtgatgt tgggccagct cctgttcagg tccagagctg ctaacgtggg ttctactcag     3300

tcccagtgac ttggccagaa tagagctttg ccaggtaact gccctgtgct aggtgaaagg     3360

ggaaaagcag tagctggata tatttcaaat gaggttttga acaagttcag aaagtggaac     3420

ttgattgaaa agtgaacaag tgtagtagtg tgtgagaaaa ttcagatggt gtcggatgca     3480

gaagttaata ttccacttaa tgttatctga gcattaaaaa tcatcagcat ttaactgaga     3540

ccccactata gagtttcctt atcaagactt tttggtttta aagttgtttt taatgcattg     3600

caagttacaa tagctatttt gcttttagat ttttcccagc actttgtatt tattagcttt     3660

cattaacttg cctccagtat acattccact tcgtgctttt cttaggtcat ttctacatcc     3720

cttattcctt gttttcctgc agtgtaatgg ccctgaatgt cctctgagcc ttcagctcca     3780

ttatggaccc aaactagact atacttggat aagttaagct cttcttcgtg tactggtcta     3840

taattagaaa aactgtttta aattagatgt tcccattatt tatttaaaca gctttttgct     3900

gagaaagctt agtggattaa tgaggcagag ggtgttttga aatccaataa atagttccca     3960

caggctgggt gtggtggctt atgcctgtaa tcccagcact ttcggaggcc gaggtgggtg     4020

gatcatgagg tcaataaatt gagaccatcc tggccaacat ggtgaaaccc catctctact     4080

aaaaacacaa aaattagctg ggcgtggtgg cgcacacctg tagtcccagc tacttgggag     4140

gctgaggcag gagaatcact ggaacctggg aggcagaggt tgcagtgagc cgagattgtg     4200

ccactgcact ccagcctggt gacagagcga gactccatca aaaaaaaaaa aaaaaagttc     4260

ccacagctca ccactacaga agcagggaag acaactatgc agaaaacaga gttagtggcg     4320

gtcagcagga atgcagctgg tcttttggac ccctacggga tgggggcagt gcagaagaca     4380

ctggtgaagt cctttatact gaagacctgt ggttgggagc aggggtagtc catgggtctg     4440

ctgatttttt ttccctattt agtactaatg tgtgtgtgat ctttgtttta caaacagtac     4500

cttttgggtt ttctgcatat tttataattt ttgtacagtt ttgaattcta tagattgtct     4560

tggaaggata ctgtgtgatg ggtcaggcac acagtaattg gagactttta atgtatgtaa     4620

tatttcatag attgcatgct attaatcatc tgtgagggta gtattttttg ttttattgta     4680

agtttccctc tttttttata aattaaaaga tggttggtat taggaatttc aaatgaatgc     4740

agaaaatctt acatgctgtg tactattaat attataacag acgatccaag tccaaaatct     4800

gaccaataaa gcaaccattt tatcaagata gagggattct aatgggagag gggattcttc     4860

cctcctgaag tttgtgtgtc cagtcccctt aaaaaaaatg aatagttgtc ttttcttgtc     4920

atattaatac tcgaaagtcc atggtggtat taatgaaagt acactttatt gttgcctttg     4980

aacttacggc caaggcaata aatcagaaac aaaaatagtg ccaatgtgtc aaaatcgaca     5040

tctgagagat tcagcctccc atttggaata aatatgaatc ttctaagcta tcttgtttaa     5100

tattttccat catttagcta cttcctatct ccctcagagg cgcctgctgt tcccatttta     5160

gagttgacag tggcctgcta attttgctat gttcctaaaa gttactgggt gtgagacatt     5220

ttcatcccct cctttttcct actgctggtg tttattatcc agctagacaa tattttatgc     5280

atatttaccg tgatgtctgg accgtacctg tgctccttgg cagtttatgt tgaagataac     5340

taaagatttt tctctttggg aggcatcaaa atgatggtag tttgctttta tctttttatg     5400

ttcattttct tttagtaggt gacctttctg cattaagaac tgtttttatc ttttactacc     5460

ttttcttttc tcctttgtgg agacagcatg acatgtcctg aaggtcacct ttgcctttga     5520

aaaaggtttg atggaggaat tcacaggtga ctgacaagtc tttgaaaaga atgggatctg     5580

ctcacttctg gtctttttgg ccgggaactc ctgattggtg ttaaggtggt aatttccccc     5640

atataagatt tagaatcact gagtttgagc tagatgaaat ttttaaaatt tctggttgtc     5700

tcattagact gatgaggtga gttttcttct tcatatgaac agctagttaa taacagcaga     5760

gttctcactc agtgctcagt acttaatttt ccactgcacc acaactgtct taactaaatg     5820

tgctgtattt ttctttaaaa gttaagagtt ctatttggtg ttttcaggaa tatacgtgaa     5880

aagacatgcc atgttttggt aaataccatc agagttgtgt aaaggcgtgt actaagtgca     5940

atcttaattt gtggaaataa tcttcattta cccctcctaa aactacactc agtataaaca     6000

ctttcccata aggtgtgtgc agtaaaaatg ttatattact ccaacactgg caggagcaca     6060

gcacagcagc cttattggag agagccttat aaaagtgatt aaatggaggc attgagctca     6120

ttacctttaa gtttactttg tgctgacctt tgttcctgtt ttgagaatct catataatta     6180

ttaaaaaaaa aaaacaatta aaacgaaacg gcggggccta gctgtgtata aatgatcctt     6240

gctgaatatc ttaaggtttt ttgtaagaaa aaagaaaaac caacaaaaaa agcttatttt     6300

cacattaaaa tgaaacctct tttgcaactt aagaattcta tggaaaagca gtttttatca     6360

tattttgtgt ccatgcacca tttttcttaa aatggcttac aaaaaagaat gtaaacaatt     6420

tgtgatctgg ccagttgtac ttttagctcc cagagggaga gttggtggta ttatgagttg     6480

agtaaaaacc atccagggga acttgaggga gcagtctgtt gccagtaatg ttccttgtgt     6540

gccattaaac cacctccaga tgagtggagg aacatcactt tttaattttt taattgtatt     6600

tggaattgtt gccgtgtact aagaacttga cctaaataaa atcccacaaa gtatattca      6659


<210> 641
<211> 1430
<212> DNA
<213> Homo sapiens

<400> 641
agcagaggac gctgccggcg gagacgggac cggaagccgg gccgcaggcg gccgggcgta       60

ttcgccgact cctcccgctt ccgctgccgc agccggtcgt aaccaagttg tgtcctgtca      120

gccgctgtcc ccttcgccgc gatgccgctg gagaacctgg aggaggaggg tctgcccaag      180

aaccccgact tgcgtatcgc gcagctgcgc ttcctgctca gcctgcccga gcaccgcgga      240

gacgctgccg tgcgcgacga gctgatggcg gccgtccgcg ataacaacat ggctccttac      300

tatgaagcct tgtgcaaatc cctcgactgg cagatagacg tggacctact caataaaatg      360

aagaaggcaa atgaagatga gttgaagcgt ttggatgagg agctggaaga tgcagagaag      420

aatctaggag agagcgaaat tcgcgatgca atgatggcaa aggccgagta cctctgccgg      480

ataggtgaca aagagggagc tctgacagcc tttcgcaaga catatgacaa aactgtggcc      540

ctgggtcacc gattggatat tgtattctat ctccttagga ttggcttatt ttatatggat      600

aatgatctca tcacacgaaa cacagaaaag gccaaaagct taatagaaga aggaggagac      660

tgggacagga gaaaccgcct aaaagtgtat cagggtcttt attgtgtggc tattcgtgat      720

ttcaaacagg cagctgaact cttccttgac actgtttcaa catttacatc ctatgaactc      780

atggattata aaacatttgt gacttatact gtctatgtca gtatgattgc cttagaaaga      840

ccagatctca gggaaaaggt cattaaagga gcagagattc ttgaagtgtt gcacagtctt      900

ccagcagttc ggcagtatct gttttcactc tatgaatgcc gttactctgt tttcttccaa      960

tcattagcgg ttgtggaaca ggaaatgaaa aaggactggc tttttgcccc tcattatcga     1020

tactatgtaa gagaaatgag aattcatgca tacagtcagc tgctggaatc atataggtca     1080

ttaacccttg gctatatggc agaagcgttt ggtgttggtg tggaattcat tgatcaggaa     1140

ctgtccaggt ttattgctgc cgggagacta cactgcaaaa tagataaagt gaatgaaata     1200

gtagaaacca acagacctga tagcaagaac tggcagtacc aagaaactat caagaaagga     1260

gatctgctac taaacagagt tcaaaaactt tccagagtaa ttaatatgta aagccatgta     1320

actaacaaag gatttgcttt agagataatt atttggaatt tttatagctt acttcacaat     1380

gtgcccaggt cagctgtata aaataaatac tgcattgttg tttctttcca                1430


<210> 642
<211> 1223
<212> DNA
<213> Homo sapiens

<400> 642
aacgtcgtgc gcatgcgccg acccggcgcc attttggtgg ccgggcgcgg aggtgattcc       60

acactgaggc gagcgcggcg gccggggtgg tagtggcagt gttcgtgtgc tcaggtctga      120

atcgccgagg gaggaggcgg tggaggaaga ggtggcggcg gtggcggtgg tcgtagcggt      180

ggcggaggag gcgggtacga atcagctgcg ggcggagaca tggccaacat cgcggtgcag      240

cgaatcaagc gggagttcaa ggaggtgctg aagagcgagg agacgagcaa aaatcaaatt      300

aaagtagatc ttgtagatga gaattttaca gaattaagag gagaaatagc aggacctcca      360

gacacaccat atgaaggagg aagataccaa ctagagataa aaataccaga aacataccca      420

tttaatcccc ctaagtacaa acaaaatccc gaaatgttca aacagacagc tcgactttgg      480

gcacatgtgt atgctggagc accagtttct agtccagaat acaccaaaaa aatagaaaac      540

ctatgtgcta tgggctttga taggaatgca gtaatagtgg ccttgtcttc aaaatcatgg      600

gatgtagaga ctgcaacaga attgcttctg agtaactgag gcatagagag ctgctgatat      660

agtcaagctt gcctcttctt gaggagcacc aacatctgtt atttttagga ttctgcatag      720

atttctttta aactggcatt cttgcctaat gatgttatct aggcaccatt ggagactgaa      780

aaaaaaaaat ccctgctctg taaataaagc taattaaacg tctgtgtaaa tttaaaaagg      840

ggaaatactt taattttttt tcttaatagt gtaaaaattc cctgagctaa gctaaaacca      900

tggaagaaac atgctacttt agtgtttagc agtgtaccaa gactagcaag agtttgcttc      960

aggattttgt tgaataatta agataatatt ttgagtgtgt cagggccatt caaattgttg     1020

gtgttgcatc acagctacct taactgtttt taacatggat cctctgtgcc tgtgaattta     1080

cttgcatgct tgtacttgac ttcttaggat gggtagctga aaagaccacc attttaagca     1140

tttgagaatt cttaaatatg aaatttattc agaattgaag atggtgacct attcagagcc     1200

tttttgtcct tgtcaacaga ctg                                             1223


<210> 643
<211> 2027
<212> DNA
<213> Homo sapiens

<400> 643
gtcatttggg aaacaaaagg agaattttac agagagagag ggatagctaa aactacgtga       60

gcctggcgag ggtgcagagc agaaagtaga gactgtccga agactgctat ctgggacgag      120

acaagttgtt aaagggacag gagagaaagc agagctattt caagagtgag ccacagaagg      180

gaatccagag gccatctaag cgaggaaggg tctacaggca gtgagtgaag gccaggagca      240

gggcccaggc caggcacgac caccgagggg atgaacttca cagtgggttt caagccgctg      300

ctaggggatg cacacagcat ggacaacctg gagaagcagc tcatctgccc catctgcctg      360

gagatgttct ccaaaccagt ggtgatcctg ccctgccaac acaacctgtg ccgcaaatgt      420

gccaacgacg tcttccaggc ctcgaatcct ctatggcagt cccggggctc caccactgtg      480

tcttcaggag gccgtttccg ctgcccatcg tgcaggcatg aggttgtcct ggacagacac      540

ggtgtctacg gcctgcagcg aaacctgcta gtggagaaca ttatcgacat ttacaagcag      600

gagtcatcca ggccgctgca ctccaaggct gagcagcacc tcatgtgcga ggagcatgaa      660

gaagagaaga tcaatattta ctgcctgagc tgtgaggtgc ccacctgctc tctctgcaag      720

gtcttcggtg cccacaagga ctgtgaggtg gccccactgc ccaccattta caaacgccag      780

aagaaacagg atctcactct gttgcccagg ctggagtgca gtggcacaaa cacaacttac      840

tgcagccttg atctcccgag ctcaagtgat cctcccatct tagcctcgca gaacactaag      900

attatagata gtgagctcag cgatggcatc gcgatgctgg tggcaggcaa tgaccgcgtg      960

caagcagtga tcacacagat ggaggaggtg tgccagacta tcgaggacaa tagccggagg     1020

cagaagcagt tgttaaacca gaggtttgag agcctgtgcg cagtgctgga ggagcgcaag     1080

ggtgagctgc tgcaggcgct ggcccgggag caagaggaga agctgcagcg cgtccgcggc     1140

ctcatccgtc agtatggcga ccacctggag gcctcctcta agctggtgga gtctgccatc     1200

cagtccatgg aagagccaca aatggcgctg tatctccagc aggccaagga gctgatcaat     1260

aaggtcgggg ccatgtcgaa ggtggagctg gcagggcggc cggagccagg ctatgagagc     1320

atggagcaat tcaccgtaag ggtggagcac gtggccgaaa tgctgcggac catcgacttc     1380

cagccaggcg cttccgggga ggaagaggag gtggccccag acggagagga gggcagcgcg     1440

gggccggagg aagagcggcc ggatgggcct taaggcctgc gccgacccga ccctgctcga     1500

gagcccgcgc tagagtcggg gaggatctgc gcagagaccg cagcatcacc caaatcggcg     1560

ccggccccgg gaggatctca ataaagaact cgagcgtccc agacccgtat ctcctttcgc     1620

tgcccaaccc cgcagcctgg gcttcgaagg cgacccgccc accatcctgc ccttcccaga     1680

acctgagacc gtctgggggg cggaagccaa atgaacccct attgggcacc tctgtgatgc     1740

caggagcgaa ctggtgagcc cagcgccctg ggaagagggc cgagggcggg gcggtggtgc     1800

cgggacctct gaggtcctgg ggatttgggg acccttgggg tccacatgca cctggctgac     1860

ctggctgaaa gccgctgtct cggagccccc cacagcattt tgttcccctc ccgctggccc     1920

gggggcccca ccttcccacg ggttcccacg ctgctgtgac tgccctgcct ctacgacaaa     1980

agccaacggg tcttcagtac ttttattaaa aaatagtcac gcagaca                   2027


<210> 644
<211> 518
<212> DNA
<213> Homo sapiens

<400> 644
gcagttgttg ttggttgggg gccttttggc cggtgacgga gactgcccag gtgtggtcac       60

catgttcctc tccgcggtct tctttgccaa gagcaagtca aaaaacattc tggtgagaat      120

ggtgagcgaa gctgggacag gtttctgctt caacaccaag agaaaccgac tgcgggaaaa      180

actgactctt ttgcattatg atccagttgt gaaacaaaga gtcctcttcg tggaaaagaa      240

aaaaatacgc tccctttaaa cggtggattg aaaatgactt tgatttataa agagaagact      300

gagggcgggg atactgattc agaaatcctg tagcgtgtaa taaaagaaga ggaaatggca      360

tggaatcact gcctcctgtg atttgaaggc cattgtgaag gaaaacaatg cagtgaaaga      420

aagttcttca tattaggaca gatatcattg catcacattt atttatcttt ctgggtattt      480

ttatagccct taataaaaaa tattaaaata gcctgtgc                              518


<210> 645
<211> 2919
<212> DNA
<213> Homo sapiens

<400> 645
atgcggccgg agggcgcggg aatggagctc ggaggcggcg aggagcgcct gcctgaggag       60

agcaggaggg agcactggca gttgctgggt aatttgaaga cgacggtgga gggtttggta      120

tcaaccaaca gccccaacgt ctggtctaag tatggtggct tggagcggct ttgcagggac      180

atgcagagca tcctctatca cgggcttatc cgtgaccagg cgtgccgccg ccagacggat      240

tactggcagt tcgtgaaaga catccggtgg ctcagtcccc actcagccct tcacgtggag      300

aagttcatca gcgtgcacga gaacgaccag agcagtgctg atggtgccag tgaacgtgct      360

gttgccgagc tgtggctgca gcacagcctg cagtaccact gcctctcagc ccagctccgg      420

cccctgctcg gggatagaca gtatatcaga aaattctaca cagatgctgc cttcctgcta      480

agtgacgctc atgtcacggc catgctgcag tgcctggaag cagtggaaca gaacaacccc      540

cgcctcctgg ctcagatcga tgcgtccatg tttgccagaa agcacgagag cccgctcctg      600

gtgacaaaga gccagagcct gacagccctg cccagttcca catacacccc tccaaacagc      660

tatgctcagc attcctactt tgggtccttc tctagcctcc accaatccgt gcccaacaat      720

ggctcagaga gaagatctac ttcctttcca ctctctggcc ctccccggaa acctcaagaa      780

agcagagggc acgtctcacc agcagaggat caaaccatcc aagccccccc agtttcagtc      840

tctgcactag ccagggattc ccctttgacc ccaaatgaaa tgagctccag tactctgacc      900

agccccatag aggcatcctg ggtcagcagc cagaatgatt ccccaggtga tgccagtgag      960

gggcctgagt acctggccat tggcaacttg gacccccgag gccggactgc cagctgtcag     1020

agtcacagca gcaatgccga gagcagcagt tccaatttgt tctcctccag cagctcccag     1080

aagccagatt ctgctgcctc ttccttaggg gaccaggaag gaggtgggga gagccagctg     1140

tccagtgtcc tccgcaggtc cagcttctca gaggggcaga cactcactgt caccagtggg     1200

gcaaagaaaa gccacattcg ctcccattcg gataccagca ttgcctccag gggagctcca     1260

gaatcctgca atgataaggc gaagttgaga ggccctttgc cctactctgg tcaaagcagt     1320

gaagtcagca cacccagctc tctgtacatg gaatatgaag gtggtcggta cctgtgctca     1380

ggggaaggca tgttccgaag accatcagaa ggacagtccc tcatcagcta cctctctgag     1440

caagacttcg gcagctgtgc cgacctggaa aaggagaatg cccacttcag catctcagag     1500

tccttaattg ctgccatcga gctaatgaag tgcaacatga tgagccagtg cctagaggag     1560

gaggaagtgg aagaggaaga cagtgataga gagatccagg agctgaagca gaagatccgc     1620

cttcggcgcc agcaaatccg caccaagaac ctgctcccca tgtaccagga ggctgagcac     1680

ggaagctttc gggtcacctc cagcagctcc cagttcagct cacgtgattc ggcacagctc     1740

tctgactctg gctctgctga tgaggttgat gaatttgaaa tccaagatgc tgacatcaga     1800

aggaacacag cctcaagcag caaatccttc gtttcctccc agtccttctc ccactgcttc     1860

ctgcactcca cgtctgctga ggcggtggcc atggggctcc tgaagcagtt tgaggggatg     1920

cagcttccag ccgcctcgga gctggagtgg cttgtcccgg agcatgatgc ccctcagaag     1980

ctcctgccca ttcctgactc actgcccatc tcaccggatg acgggcagca cgctgacatc     2040

tacaagctgc ggattcgtgt tcgtggcaac ttggagtggg ccccgccccg gcctcagata     2100

atttttaatg ttcatccagc cccaacgagg aaaattgccg tggccaagca gaattaccgc     2160

tgtgcaggat gtggcatccg gactgaccct gattacatca agcgactgcg gtactgtgag     2220

tacctgggca agtacttctg ccagtgctgc cacgagaatg cccagatggc catccccagc     2280

cgggttctgc gcaagtggga cttcagcaag tactacgtca gcaacttctc caaggacctg     2340

ctcattaaga tctggaatga tcctctcttc aacgtgcagg acataaacag tgccctctat     2400

aggaaggtca agctgctcaa tcaagtccgg ctgctgcggg tccagctgtg tcacatgaag     2460

aacatgttca agacttgccg actggccaag gagcttctgg attcctttga cacagtccca     2520

ggccacctga cagaggacct ccacctgtac tcactgaatg acctgactgc gaccaggaag     2580

ggggagctgg ggccccggct tgctgagctc accagggcag gggctaccca tgtggagaga     2640

tgcatgctct gccaagccaa aggcttcatc tgtgagttct gtcagaatga ggatgacatc     2700

atctttccct ttgagctcca taagtgccgg acctgtgaag agtgtaaagc gtgttaccat     2760

aaagcctgct tcaagtctgg aagctgtccg cgctgcgagc ggctgcaggc ccggcgggag     2820

gcactggcca ggcagagcct ggagtcttac ctgtcagact acgaggagga gcccgcggaa     2880

gcgctggccc tggaagccgc cgtcctggag gccacctga                            2919


<210> 646
<211> 2791
<212> DNA
<213> Homo sapiens

<400> 646
ctcccgcgcc caggccagcg gcgggcccag ctcctccccc gactcggtct ctctcccctc       60

ccctccgccc ggcagttcct ccctcccgcc gccgcctctt cctcggtgag gcgctcttcc      120

agcgggcagg cagcatggcg gccgtggaga cgcgggtgtg cgagacagac ggctgcagca      180

gtgaggccaa gctccagtgt cccacttgca tcaagctggg catccagggc tcgtacttct      240

gctcgcagga atgttttaaa ggaagttggg ctactcacaa gttactacat aagaaagcaa      300

aagatgaaaa ggcgaagcga gaagtgtctt cctggactgt ggaaggtgat attaatactg      360

acccatgggc aggttatcga tatactggta aactcagacc acattatcca ctgatgccaa      420

caaggccagt gccaagttat attcaaagac cagattatgc tgatcatccc ttaggaatgt      480

ctgaatctga acaggctctt aaaggtactt ctcagattaa attactctca tctgaagata      540

tagaagggat gcgacttgta tgtaggcttg ctagagaagt tttggatgtt gctgccggca      600

tgattaaacc aggtgtaact actgaagaaa tagatcacgc tgtacactta gcatgtattg      660

caagaaattg ctacccttct cccctgaatt attataattt cccaaagtct tgttgtacct      720

cagtgaatga agtcatttgc catggaatac cagacagaag gcccttacaa gaaggtgaca      780

ttgttaatgt ggatatcact ctttatcgca atggttatca tggggacctg aatgagacat      840

tttttgttgg agaagtggat gatggagcac ggaaacttgt tcagaccaca tatgagtgcc      900

tgatgcaagc cattgatgca gtgaagcctg gtgttcggta cagagaattg ggaaacatta      960

tccagaagca tgcccaagca aatgggtttt cagttgttcg aagctattgt gggcatggaa     1020

tccacaagct ttttcataca gctcccaatg taccccacta tgctaaaaat aaagcagttg     1080

gagtgatgaa gtcgggccat gtatttacaa ttgagccaat gatttgtgaa ggcggatggc     1140

aggatgaaac ctggccagat ggttggactg cggtgacaag agacggaaag cggtctgctc     1200

agtttgagca caccctcctg gtcacagaca ctggctgtga aatcctaacc cggcgacttg     1260

acagtgcacg gcctcacttc atgtctcaat tttaatttct cccaagatgg cacatctcag     1320

taccttctta ctgtgctatg cattttattg agagtacaga aaggaagagg aacctttttt     1380

taatcacttg ttttgttttg actatagata agaaaggact acagcatttg atgtgtgtcc     1440

tcaagaactt gtcttgggtc tgaaaaagct gagaagaata aaggaaacat tgctcaactc     1500

ttcagccccc tccccctgca cacctgtttt ctcatttgcc ctttgagcac ttttacttaa     1560

acttgcttgt agttgctttt atcactgccg caaaacagcc atcaagagcc atctgctttc     1620

caggtgaaca ttggaaatga gaatctttga aacttagcaa tatgtgttgc accagatttt     1680

ttaaattata tatatggaaa tatatatgta tacattttaa gttctgtata cataattacc     1740

aaacactatg tgacctggag tttgtgttgt ttctgctctg acaggtttat atgttcttac     1800

aaatggatcc atagtttgca gtgatttaat tcctggttgg gatttggcct cccctctccc     1860

ccatgctaat tatttaccct tgtaattgtg catagggaag cactcaccca atgagacttt     1920

ctccaatgtg gactctgtgt gtcagtgaat gaatgtagta aaattcactt tggaaggtta     1980

tcaggctttt aaaaatctag tttatggcaa aaatagccat tttccaagtg gtggctgact     2040

gttgcaggga atgagaattt cataatacac tgctatttca gacctctgtt tggtcagaaa     2100

tggaaaagaa aaagccccct ttcttccctt ttctgtttta cttcaagggc ataccttgga     2160

ggtgctcaga gaagcgtgaa gtttgcacta tggtggagga tggggaaaga gttctaaagt     2220

gtctccagct gtgaacccag gaggtcaagt gggctattaa aatctaacgt tgagtaaatg     2280

tgatagtgat gagaaaggaa ttttgtgtac tgtaaccttg cagtagagat gcagctgtcc     2340

ttcgtgtgtg gaaacacacc tctcctttac atagttggga acctcattag aaatgacctc     2400

agctgcccca tatctacgtt cctttcagca gttgtccaag taggagtgta tccagtgaag     2460

acatatcaaa tcacaaagtc attgtcatta gagtgtactt gattactggg catccttgta     2520

atataatttc ataccactga cacattatac ttgtaagaga acatctttcc cagagtgcct     2580

cagaccttat tgctttaaaa tataataatg ttttcattac ttttattatt tgaatgattt     2640

agtaaagttg actgaatctg gtatagactt tgggagtatg tgtgtgaagt ttttatcaaa     2700

ctgtaatatt tgtgaatgga atgccttgca atatgaatgt taatataatg tgtaaaggga     2760

gattaaaaag tttgaatgat tatcctacca t                                    2791


<210> 647
<211> 1126
<212> DNA
<213> Homo sapiens

<400> 647
agcatgcatt attaagcgct tgacttgctt ccagacaaag gttgtctcaa gtttgttgct       60

caaaccgagt tctggagaac gccatcagct cgctgcttaa aattaaacca caggttccat      120

tatgggtcga cttgatggga aagtcatcat cctgacggcc gctgctcagg ggattggcca      180

agcagctgcc ttagcttttg caagagaagg tgccaaagtc atagccacag acattaatga      240

gtccaaactt caggaactgg aaaagtaccc gggtattcaa actcgtgtcc ttgatgtcac      300

aaagaagaaa caaattgatc agtttgccaa tgaagttgag agacttgatg ttctctttaa      360

tgttgctggt tttgtccatc atggaactgt cctggattgt gaggagaaag actgggactt      420

ctcgatgaat ctcaatgtgc gcagcatgta cctgatgatc aaggcattcc ttcctaaaat      480

gcttgctcag aaatctggca atattatcaa catgtcttct gtggcttcca gcgtcaaagg      540

agttgtgaac agatgtgtgt acagcacaac caaggcagcc gtgattggcc tcacaaaatc      600

tgtggctgca gatttcatcc agcagggcat caggtgcaac tgtgtgtgcc caggaacagt      660

tgatacgcca tctctacaag aaagaataca agccagagga aatcctgaag aggcacggaa      720

tgatttcctg aagagacaaa agacgggaag attcgcaact gcagaagaaa tagccatgct      780

ctgcgtgtat ttggcttctg atgaatctgc ttatgtaact ggtaaccctg tcatcattga      840

tggaggctgg agcttgtgat tttaggatct ccatggtggg aaggaaggca ggcccttcct      900

atccacagtg aacctggtta cgaagaaaac tcaccaatca tctccttcct gttaatcaca      960

tgttaatgaa aataagctct ttttaatgat gtcactgttt gcaagagtct gattctttaa     1020

gtatattaat ctctttgtaa tctcttctga aatcattgta aagaaataaa aatattgaac     1080

tcatagcagg agaatagttt ttaaaataaa tctcgatttg ttagca                    1126


<210> 648
<211> 4128
<212> DNA
<213> Homo sapiens

<400> 648
ttttccagat ctttctcgaa cccgcagctt cttgggcagc cgttgcccga gtgctgacgg       60

aagcggccga agtccgggcc cggagctggc tcgggcgcgg agcggaggct cgcgcgcctc      120

ccgggcagcc gagcgcgcag gcgcaggtcc cagtaaccgc cggttggagg cggccgaacc      180

gcagtaggga aagacccagg ctgcgggacg cggtgcaggc tgcggcgctg acggcctctg      240

ctccttccgc gggtttccga ctccctgccc tagattttct gcttagcgac ttggggtccc      300

ctctcgtttg cttctggtag gagtcgcaat cccagcagca atagcccaga agaggacacg      360

gttcccgtac cgaagggttc agtaccagca gcccgaccat cacgcggcgg gatgtctgtg      420

gttggcattg acctcggctt tctcaactgc tacattgctg tcgcgagaag tggcggcatc      480

gagaccatcg ccaatgagta cagcgacagg tgtaccccgg cctgtatatc attgggatca      540

agaactcgag ccattggaaa tgcagcaaag agccagatag tcacgaacgt aagaaataca      600

attcatggct tcaaaaagct tcatgggcga tcatttgatg atcccattgt gcaaactgaa      660

aggatcaggc ttccctatga actgcagaaa atgcctaatg gaagtgcagg agttaaggtg      720

cggtacttag aggaagagag accttttgca attgagcaag ttactggaat gctgttagcc      780

aagcttaaag agacttcaga aaatgctttg aagaaaccag tggctgactg tgtgatttca      840

attcctagct tttttactga tgccgagaga agatctgtga tggctgcagc ccaggttgca      900

ggcttaaatt gtttaaggtt gatgaatgaa actactgcag ttgcactggc gtatggaatt      960

tataaacagg atcttccccc attagatgag aaaccaagaa atgtagtatt tattgatatg     1020

ggacattctg cctatcaggt cttggtttgt gcttttaaca aaggaaaact taaagtcttg     1080

gctactacct ttgatccata tttgggtggc aggaactttg atgaggcttt agtagactac     1140

ttctgtgatg agttcaagac caaatataag ataaatgtga aagaaaactc tcgggccttg     1200

ttgcgtttat atcaggaatg tgaaaaacta aagaagctaa tgagtgcaaa tgcatcagat     1260

cttccattga acattgagtg tttcatgaat gaccttgatg tttctagtaa aatgaacagg     1320

gctcaatttg aacaactgtg tgcttccctt ttggccaggg ttgaaccacc tttaaaagca     1380

gtaatggaac aagctaactt acaacgtgaa gacattagta gtatagaaat tgtaggagga     1440

gcaacacgaa ttcctgcagt gaaagaacaa atcactaaat tctttcttaa agacataagt     1500

accacattaa atgctgatga agctgttgca agaggatgtg cgttacagtg tgcgattctc     1560

tcaccagcat ttaaagtgcg tgaattttcc ataacagacc ttgttcccta ttcaatcaca     1620

ttaaggtgga agacctcttt tgaagatgga agtggggaat gtgaagtttt ctgtaagaac     1680

catcctgccc cattctcaaa agtcattact ttccacaaga aggaaccatt tgaactagaa     1740

gcattttata ctaatttaca tgaagtgcct tatcctgatg caagaattgg gagcttcact     1800

attcagaatg tttttccaca gtctgatggt gatagttcca aagtgaaggt taaagttcgt     1860

gttaacatcc atggaatctt cagtgtggct agcgcatcag taattgagaa gcaaaatttg     1920

gaaggcgatc acagtgatgc tccaatggag acagaaactt catttaaaaa tgaaaacaaa     1980

gataatatgg ataaaatgca ggttgatcaa gaagaagggc atcaaaaatg tcatgctgaa     2040

cacactccag aagaggaaat tgatcataca ggagccaaaa caaagtcagc tgtctcagac     2100

aaacaagacc gattaaatca gacacttaaa aaaggaaaag tcaaaagtat tgatctaccg     2160

atccagagta gcctatgtag acaactaggc caagatcttc tcaacagcta cattgaaaat     2220

gaggggaaga tgatcatgca agataagtta gagaaagaaa gaaatgatgc taagaatgcc     2280

gttgaagaat atgtatatga ttttagagac aggctgggca ctgtctatga aaaattcatc     2340

actccagaag acttgagtaa actgtctgca gtattggaag acacagaaaa ttggctttat     2400

gaagacggag aggaccaacc taaacaagtt tatgtggata agcttcaaga actaaagaaa     2460

tacggccagc ctattcaaat gaagtacatg gagcatgaag agagaccaaa agccttaaat     2520

gacttgggaa aaaagatcca acttgtcatg aaagtgatag aagcttatag aaacaaggat     2580

gaaagatatg atcatctgga tcctactgaa atggaaaagg ttgaaaaatg tatcagtgat     2640

gccatgagtt ggctgaatag taagatgaat gcacagaaca aactaagtct cactcaagat     2700

cctgtggtaa aagtttcaga aatagtagca aagtcaaagg aactggataa tttctgtaac     2760

cccatcattt acaagcccaa accaaaagca gaagttcctg aagacaaacc aaaagctaat     2820

agtgaacaca atggcccaat ggatggacag agtggaactg aaactaaatc agattcaaca     2880

aaagacagct cacagcatac taaatcctct ggagagatgg aagtggacta agtcttaatt     2940

ttaccttcac attaattcaa accgtgcaag taaccacggg gtccatcttt tacatctggt     3000

acacacaaca gacgctcagt tgttcttaac cacttttgtc atttgttttt tggagtagtt     3060

ttgaaaagtg ttttatattg agtgcacttc tgttcatttc cattgctgct tatatgcagt     3120

gttagccgaa ttagatttac aagacaatct aagctttccg gataatttta tatatcaaac     3180

atacaggatg gatacatagt tggcaacagt ctaccttatt taaagcttct actgggataa     3240

acctcaattc ctttattcag gaaaggatac tttattgcat tattgttgca gaagcataga     3300

tttaattgca tctttatttt gaaaaacaaa tgaaaattga tggggtttaa agctacagag     3360

gcactgacct ttttctagtt attgtattgc tacaatttaa atattaaaac aaataagagc     3420

tttctcaaca aattagtcca tctcattgat gtaccacaga aatccaaagc tttgctgtca     3480

tcacataaat gaattaaatc acatgtgaaa gggaacacac ccaattttat gttaaggtga     3540

aaccagcagt ttgcttcttt tattagtaat gtggattgat gttttctcag agtaactcgt     3600

tgtcttttcg cttgaaattt ttgatcttgt cctgaagact agctgctgct aaaacaatgc     3660

tagcctaaag atacaggagt ctctgacaaa atgactttca tgttaagggg aaatgctgtt     3720

tatctactca gacatgcatc tgtgatgttc atagccttgt ttcagttata atagttgtct     3780

tgtttttttc ttaattgatt ttgttaataa taccttaaca cagggtagga agaagtggca     3840

cagtgtattg cattatatac atttatcatt gatttaccta atgttacctt gtagattaaa     3900

cactattaag tggtaatact tgaaaaggag cacttatacc ataagtctta ggaaataatg     3960

tttgtaataa acttaactat gttacatatc aacaggcaaa aatatagaat gttacatagt     4020

gttgtgtgat taaattatag ttcctgctgt taacattacc ttttgaaacc ttggctccag     4080

ttttggtgct tcttatacaa attaaatgcg aaaagggact gtaaactt                  4128


<210> 649
<211> 1898
<212> DNA
<213> Homo sapiens

<400> 649
aacggccacc gcagctgcct tcggcgccgc cagccccgcc atggctgcgc cctgcgcgga       60

ggacccctcg ctggaaaggc attttaaggg ccaccgagat gcagttacct gtgtggactt      120

cagtatcaac acaaagcagc tggccagtgg ctccatggac tcatgcctca tggtctggca      180

catgaagccg cagtcacgcg cctaccgctt cactggccac aaggatgccg tcacctgtgt      240

gaacttctct ccttcgggac acctgcttgc ttccggctcc cgagacaaga ctgtccgcat      300

ctgggtaccc aatgtcaaag gtgagtccac tgtgtttcgt gcacacacag ccacagtgag      360

gagtgtccac ttctgcagtg atggccagtc cttcgtgaca gcctctgacg acaagacagt      420

caaagtgtgg gcaactcatc gccagaaatt cctgttctcc ctgagccagc atatcaactg      480

ggtccgctgt gccaagttct cccccgacgg gcggctcatc gtgtctgcca gtgatgacaa      540

gactgttaag ctgtgggaca agagcagccg ggaatgtgtc cactcgtatt gtgagcatgg      600

cggctttgtc acctatgtgg acttccaccc cagtgggacg tgcattgccg ctgccggcat      660

ggacaacaca gtgaaggtgt gggacgtgcg gactcaccgg ctgctgcagc attatcagtt      720

gcacagtgca gcagtgaacg ggctctcttt ccacccgtcg ggaaactacc tgatcacagc      780

ctccagtgac tcaaccctga agatcctgga cctgatggag ggccggctgc tctacacact      840

ccacgggcat cagggaccag ccaccactgt tgccttttca agaacggggg agtattttgc      900

ttctggaggc tctgatgaac aagtgatggt ttggaagagt aactttgata ttgttgatca      960

tggagaagtc acgaaagtgc cgaggccccc agccacactg gccagctcca tggggaatct     1020

gccagaagtg gacttccctg tccccccagg cagaggcagg agtgtggagt ctgtgcagag     1080

ccagccccag gagcccgtga gtgtgcccca gacactgact agcacgctgg agcacattgt     1140

gggccagctg gatgtcctca ctcagacagt ctccattctg gagcagcggt tgacactgac     1200

agaagacaag ctgaagcagt gtctggagaa ccagcagcta atcatgcaga gagcaacacc     1260

atgatcaggg gagcaggaat caggagctcg gtggatttgc aggtggcagg ccagggattt     1320

gtaccatggg acttgggtaa ataaagggga ctgaactctg tgggaatcac atccatactg     1380

gagccctgga tttttgcagt tctgccctcc accttgctat ctgcaccagg aggctctcca     1440

cctggcagcc agaggtcccc agtgggccgg gctcacacac aaatgatgct tcagacccga     1500

atgagaggac cacattttgc ttaatgtaaa ggagccactt gaaaatgtct gctccttcgg     1560

ggtcctgaga ttgtggctcc ccctctggag gaggtggctc cacgatgcct tgattttcac     1620

tcatcatttg gacatgtgac tggcttttcc tacctctgcc atggtgtaga aattgattgc     1680

acattgattg gatgagccgg gggttttctc taaatctgac taaaggccca aagtgggccc     1740

atctgagtca ggtttgttga gaacaagccc tctcaagtgg gtggtggctt ttcagtggcc     1800

ctgatttctg ttccacacgt gttcactgga gccaggtgac ttcctccttg cgtgagtgag     1860

ggcacaggaa tctcaaaatt aaacctgact tcattgca                             1898


<210> 650
<211> 4173
<212> DNA
<213> Homo sapiens

<400> 650
aggtgaaaaa ttagacgatt tcaagaattg gagctgaatc tgatgttaag taatggcaac       60

aggtgactta aaaagaagct tacggaacct agaacaggtg ctccgcttgc taaattatcc      120

tgaagaggtg gactgtgtag gtttgataaa gggagaccca gcagcatctt tgcccatcat      180

cagctattct tttacctcat actcacctta tgtaacagaa cttataatgg aatccaatgt      240

agagctcata gcaaaaaatg acttgcgctt tatagatgct gtctataagc ttcttcgtga      300

tcaatttaat tataaaccaa ttttgacaaa aaagcagttt atccaatgtg ggtttgcaga      360

atggaaaatc caaattgttt gtgatatttt gaattgtgtg atgaaaaagc acaaggaatt      420

aagcagtctt cagaagattc catcacaaca aagaaagaaa atcagttctg gtaagtcaga      480

acctcctttg ggcaatgaga aaatatctgc agaggctgtt ggcgttgata tcagtggcag      540

gtttatgacc tcaggaaaga agaaagctgt ggtgattcgt cacttgtata atgaagataa      600

tgttgacatt tctgaggata cattaagtcc aataacagat gttaatgaag cagttgatgt      660

gtctgactta aatgctactg aaataaagat gcctgaagta aaggttcctg aaatcaaggc      720

tgagcaacag gatgtaaatg ttaatcctga gattactgca ctacaaacta tgcttgctga      780

atgccaagaa aatcttaaga aactgacttc gatagagaaa aggttagact gtttggaaca      840

aaaaatgaaa ggaaaagtga tggtagatga aaacacctgg actaatcttc ttagtcgtgt      900

cactcttctt gaaacagaaa tgcttttgtc taaaaagaat gatgaattta tagagtttaa      960

tgaagttagt gaagactacg cttcttgtag tgacatggac cttctgaatc ctcacagaaa     1020

aagcgaagta gagaggccag caagtattcc tctgtcctct ggctatagta cagcatcatc     1080

agattcaact cccagagcct ctactgttaa ttactgtggt ttgaatgaga tttcagagga     1140

aacaacaatc cagaaaatgg aaaggatgaa aaaaatgttt gaagaaactg cagagttact     1200

gaaatgtcca aatcactact tgtaggattt tctacatgaa cttttttcta ggactttggt     1260

tactatacat attgtatatt ttaagaattc tttatacaat tttaatatac tgcaatactg     1320

cagtttttga caatttggat tccatttggt atatgaattt ttgcattcat tattgaataa     1380

ctcttttaat atttttgagc aatgattata ctgctttacc ttgtgtcact tttttttttt     1440

ttaggaaaaa ctcatgttcc agtatatttc tcttacagag tgaagtcatt acagcactgt     1500

atttctgtgt tgacatttgt tggcagtgtg ctaagtaatg ttttttaaag cacaggcttg     1560

aggactatgg tttacatcct gttggaaaca ttccaaatgg gacttgtgta ttatacccag     1620

gaggctctca tatataccat cttggcatct gtactgatga ataagttata atgaacagtt     1680

aaaaatgctc attgaaaatt aaataaaaca aaaaggcagt tatttcatgc ttggtcaaaa     1740

acatcaatac ctttccaatt aacactgaga aattaaggtt aagattctcc ttttgtactg     1800

ggaaacaggc tggaggacta tggtcctcaa gtttagacca agaggactat ggtctcaagg     1860

ttcaccatga gaaatgtgtt gaacatttta gtatgctcta ttgtataatt tttttggagg     1920

gggggatgga gtttcgctgt tgttgcccag gctggagtgc aatagcacga tcttggctca     1980

ccgcaacctc tgcctaccgg gttcaagtga ttcttgtgcc tcagcctcct gagtagctgg     2040

gattataggc atgcaccacc atgcccagct aattttgtat ttttattaga gacagggttt     2100

ctccgtgttg gtcaggctgg tctcaaactc ctgacctcag gtgatctgcc tgtcttggcc     2160

tccggcgtaa cactttttaa gaccagtgta acagaaagag aatgtagcca ttctagccac     2220

cgttaaaaga tacacagtga ggtgttgtgt tttgtttttt taatgatgaa aagttacaca     2280

ttttttggag agaaaagtct tagctgaagg taaatcaatg gaaaaatgaa atttattttt     2340

aatattacta ctatatgaat tatctttttt taaacttgta gataaaagtg ttccagtaat     2400

cagaaaatcc tcaagaaaat tgacttcatt atttggaagg aaaattagta ttttttttaa     2460

tattatatgg accatctgat tatattttat ttattcatct atttatggta tgtatgtata     2520

attctatatt acactgtcaa atataaaata ttgttatatg agtagaaatc acttaaattt     2580

tttttgtgtt tgtgaatttg aaacagtgta agaaatcact tttaagaaaa catttttaga     2640

attcctttgt tttttttttt tttctttttg aaacagggtc tcactctatt gcccaggctg     2700

gagtgcactg gcgtgatctc ggctcactgc accttctgcc taccgagttc aagcgattct     2760

tgtgcttcag cctcctgagt agctgggact ataggcctgt accgtcatgc ctggctaatt     2820

tttgtatttt tgtagagaca gggtttcacc atgttgccca gtctgttctc aaactcgtga     2880

gctaaagcta ctcgcccacc tggatgtccc aaagtgctag attccatggg tgagtcacca     2940

tgcttggcca catttttagt attctaataa acagttggtc atcagaactt taaaatggta     3000

gcctacagaa acatacaatt ttgaatttaa cagagtttca gtaaatattt ccagaattaa     3060

tgaagcatgt tagctttaat tttttcaatt gtgagagaag tacatttata aaaattaaga     3120

ggttaagagg ttatagttat aagggaaaaa acttctgtat cgattaactc ctaaaatatc     3180

agtaccagca tggaattata gcaccacctt gtggttaaca tgccagtatt ttaccttttg     3240

ttaaaacaag tgatttccca tcaaacagga taatattttt tcccttttga aaaattcaat     3300

tttaaaaaga aacatttttg aagttttctt atggaagata gaaaaaaagt taagtctctt     3360

tctacccttt ctttttttct ttatatagtg cagatataca cacagagaag ggacttaaaa     3420

catttctaat ctcctagttt atatacagtg tgcaaaatat aagtaagtat atattgaaaa     3480

tataaaatat ttcatatatg ttatcaggtg gaaatttaga atccaaattt tcttaaactt     3540

taataacttg tctaacaact ctctaatagg gactaaaaat caactcaata tatcatacat     3600

ttacacttac aaagagtctt tatctagaca acataatttt tggaaaaata aagcaaattc     3660

aactttattg gagttattgg acagatcagc aaattgttat tttaaaaagt tttcttgttt     3720

aggcaatttg gtaagtggtt tctagttata aactagccac tgttgattaa cttgagaagg     3780

tgaagcaggg gagttctgaa gagattacct agagctacat aaccctaagt taagtaaaat     3840

tttcactttc attcttttca ttctctcata aactggttga aaaaacactg tactaccaac     3900

aaaggtgtca gttgcttgtg ctgccctgtc tatgttatgc tctgaatagg tctcggtaaa     3960

gattatatgg aaatactata aagaatacat aaggtaaaat actagtcaga aagggttcag     4020

aagaagttag catcaactgt atgaaaattc taggtaaagc taagtactat tgagttggaa     4080

aaaagtaatt ctatcatgtt tgcttgtttt cctctactgt ttttaatgtg atgttgtaat     4140

atattttaaa aataaaactt gaaaacgttg gga                                  4173


<210> 651
<211> 6208
<212> DNA
<213> Homo sapiens

<400> 651
gtgttaggaa gcgtgacccg ggtgggaaaa ccctccgcgt ccgccatttt ggctgcctct       60

gtcggtctgt tcagttacca cgtgaaccgc cgacggagac ccgtagtggg ggaggcggcg      120

gcagcgttaa gtgagaaagg aaaaaagaca acgaggaaaa aggaggtgtc cgggtagggc      180

aacgcggcga cacccgaggc ctggtggtgg cggcggatcg agatattcaa ggctgaagca      240

gctacggaac ggcagcggcg gcggtcggac aaactgactg accgagccgg gtggtggcgg      300

gagcagcggg agcagccgga acgatgccgg ccgtgagcct cccgcccaag gagaatgcgc      360

tcttcaagcg gatcttgagg tgttatgaac ataaacagta tagaaatgga ttgaaattct      420

gtaaacaaat actttctaat cccaaatttg cagagcatgg agaaaccttg gctatgaaag      480

gattaacatt gaactgtttg gggaaaaagg aagaagctta tgaattggtt cgtagaggtt      540

tgagaaatga cttgaagagt catgtgtgtt ggcacgttta tggccttctt cagaggtcag      600

acaagaagta tgatgaagcc attaagtgtt acagaaatgc actaaaatgg gataaagaca      660

atcttcaaat cttaagggac ctttccttac tacagattca aatgcgagat cttgagggtt      720

acagggaaac gaggtatcag ttacttcagc ttcgacctgc gcagagagca tcatggattg      780

gttatgctat tgcttaccat ttattagaag attatgaaat ggcagcaaag attttagaag      840

aatttaggaa aacacaacag acatcccctg acaaggtgga ttatgaatat agtgaactac      900

tcttatatca gaatcaagtt cttcgggaag caggtctcta tagagaagct ttggaacatc      960

tttgtaccta tgaaaagcag atttgtgata aacttgctgt agaagaaacc aaaggggaac     1020

ttctgttgca actatgtcgt ttggaagatg ctgcagatgt ttatagagga ttgcaagaga     1080

gaaatcctga aaactgggcc tattacaaag gcttggaaaa agcactcaag ccagctaata     1140

tgttagaacg gctaaaaatt tatgaggaag cctggactaa atatcccagg ggactggtgc     1200

caagaaggct gccgttaaac tttttatctg gtgagaagtt taaagaatgt ttggataagt     1260

tcctaaggat gaatttcagc aagggttgcc caccagtctt caatacttta agatcattat     1320

acaaagacaa agaaaaggtg gcaatcatag aagagttagt agtaggttat gaaacctctc     1380

taaaaagctg ccggttattt aaccccaatg atgatggaaa ggaggaacca ccaaccacat     1440

tactttgggt ccagtactac ttggcacaac attatgacaa aattggtcag ccatctattg     1500

ctttggagta cataaatact gctattgaaa gtacacctac attaatagaa ctctttctcg     1560

tgaaagctaa aatctataag catgctggaa atattaaaga agctgcaagg tggatggatg     1620

aggcccaggc cttggacaca gcagacagat ttatcaactc caaatgtgca aaatacatgc     1680

taaaagccaa cctgattaaa gaagctgaag aaatgtgctc aaagtttaca agggaaggaa     1740

catcagcggt agagaatttg aatgaaatgc agtgcatgtg gttccaaaca gaatgtgccc     1800

aggcttataa agcaatgaat aaatttggtg aagcacttaa gaaatgtcat gagattgaga     1860

gacattttat agaaatcact gatgaccagt ttgactttca tacatactgt atgaggaaga     1920

ttacccttag atcatatgtg gacttattaa aactagaaga tgtacttcga cagcatccat     1980

tttacttcaa ggcagcaaga attgctatag agatctattt gaagcttcat gacaaccccc     2040

ttacagatga gaataaagaa cacgaagctg atacagcaaa catgtctgac aaagagctaa     2100

agaagctacg taataaacaa agaagagctc aaaagaaagc ccagatagaa gaagagaaaa     2160

aaaatgcaga aaaagaaaag cagcagagaa atcagaaaaa gaagaaggat gatgatgatg     2220

aggagatagg aggtccaaaa gaagaactta ttccagagaa actggccaag gttgaaactc     2280

cattggaaga agctattaaa tttttaacac cgttgaagaa cttggtgaag aacaagatag     2340

agactcatct ttttgccttt gagatttact ttaggaaaga aaagtttctt ttgatgctac     2400

aatcagtaaa gagggcattt gctattgatt ctagtcatcc ctggcttcat gagtgtatga     2460

ttcgtctctt taatactgca gtgtgtgaaa gtaaagattt atctgataca gttagaacag     2520

tattaaaaca agaaatgaat cgtctttttg gagcaacgaa tccaaagaat tttaatgaaa     2580

cttttctgaa aaggaattct gattcattgc cacacagatt atcagctgcc aaaatggtat     2640

attacttaga tccttctagt cagaagcgag ctatagagtt ggcaacaaca cttgatgaat     2700

ctctcactaa cagaaacctc cagacatgta tggaggtatt ggaagccttg tatgatggta     2760

gcctaggaga ctgtaaagaa gctgctgaaa tttatagagc aaattgtcat aagcttttcc     2820

cttatgcttt ggctttcatg cctcctggat atgaagagga tatgaagatc acagttaatg     2880

gagatagttc tgcagaagct gaagaactgg ccaatgaaat ttgaacatca ctaaacaagc     2940

aaatggaatg actttggacc atatctagta tataatattt ttgtcacgca cctgctgcat     3000

tgctctaact tacacagaat gagaggagta aatgttcttg ccttcaaata gtgttttacg     3060

ttttttatcc tgctgaaaaa gtatatataa aatatctaac attacaggat agaggttcag     3120

tttcttaaaa aattaaagct gctaaaattg agtggttaaa aaagatacct tatcctattc     3180

ctccccaccc acccatgttt ttaaactaat ttatataaaa tctggaggct gttacagcta     3240

acaaagcagg tgtgtggcag aaatattact ttaaatttgt cttgtgagat tttactatat     3300

ctcagacagc ataaatgctg ttttagcact ggattctttc actgagcaca aagagttgtt     3360

ggggctttag catctgactg attttgttac ggggttgatt ctgaccatag gaagtatgca     3420

atgtgaatca ctatttacag agaaacctac aacagatgct tgatgttgta gaaactggga     3480

catatagata ccaagcaaaa ttataagaaa cctataaggt gttcaatacg cttgtgtttc     3540

caaaattcac tgtacatgat cagtttggtg ttcttgtacc acagttttta actgaaggaa     3600

ccagttgtaa cagtctcaat tttaactaaa acttgaagaa ctaaaacaac aatgcaaacc     3660

tttcagcatt gtttggccaa acttgttaaa actgtaatgc aagaaccaaa tgcactgtga     3720

tgtggcacca actaattagc aagcatgaat ttttcaccca agagtgaaaa aaggaaaatc     3780

taccatggct tgaagttaaa gagcagaact cctgactacc attctatgac tgatcaaaag     3840

actaatagtt aaaaacctca gcaggccttg ttcacgatat gcagaaaaaa aagtgctgca     3900

gtttagatac ctctggaatt tttccacagt gtcacaggtt tgtaatactt gaagccctac     3960

atttctaaga atatatttct tgctcagttg tttcaggcaa gcccaagact ttgtaatttt     4020

taaagggccc aagatttttt tttttttttt ttttttcaaa taacagacca gcttcttttt     4080

cttgcagtta cagatgtaat ttcctttttg ttgtcaaaca taaggtacca aatatgatgc     4140

aataaattgt tttgaaaaac agttgtgtga atatttcaac taatctgtgt tgggcttctg     4200

tgaaatacac aggtggaaac agaggtgcaa gccagaggca atgtaatatg ctgtaaggct     4260

agtgcagatg ggagcttttt agaaggggct aagtgctggt gtcagggaaa ttccataatg     4320

aagtagaatg ctgctcctgc attaagattt cattgagggc aaggctggtg gcaggtacta     4380

tgaatgtaat tcataattta aaaggaaaac taaaaactat tttgatttgg gaaaatgagc     4440

cttaatttgt taaacctata cactgagaac tagcctcagg cttaatattc tcattgcatt     4500

tgcaagatct gagcaaataa gattaagtaa aacaaatcaa ttgtatatat aattgacctt     4560

tttgtggaac atgtagttta tagaaagtat actctaaagg gaatttgccg aagacctttt     4620

actgattgaa cagttgtgct acaatcaact tttcatagta catgacctgc attccacatc     4680

tcagtctaac agtttagtag tgatgtaaag agaagtacaa accgaactcc agtgctttgt     4740

tatgttttat taactggccc tgtctcagga acatcttaac agatggcaaa aaaacaaaaa     4800

ctttttttca actcctatga gtggcaactg aagttcttat tgttgggaaa gaacactagt     4860

cctacctctg ccactaatga ggtgtttgga ggaggtacca gccatataat agggggtgta     4920

tgtgtgaatt ttgtttaaac tctactgtat attgaaatga aattcattta tttgtcttga     4980

caatgttcaa atgatgtaga ttgtcttaga atgaatattc ataagtactc agaactctta     5040

agatgcagat gccacccgtg aggagctaaa ttcctaatgt gtattgtatt ccaacccaat     5100

tttactggaa ctattgaata aatcttttat tttctttcag gtttacttga tagtggatac     5160

attggtgtca gaggaccttg actgggttca ttttatgtcc agacatcacc cctgaaacac     5220

tgtactgtac tatcttgctc tgagtagtat caactggatc gtctcatatt tgcctcattc     5280

atcctattaa tttcaaatga tactgtgggg gaaaaacagg gttagaaaaa caagtggaaa     5340

aaatggagtg atgttgtaat ctaaacaagt gccttatgtt tattgctaag aactggtgtt     5400

accaaccctt ttgagaagaa agggtctctt gacctgtatt aacataggaa agtaaagttc     5460

tttttgtttt tctttatatt cagctactct tgtcatttct cgttgaaaaa ctaaaatctg     5520

actaggttag tttactcagc tttaattaga tagttgagtc atatattttc aacatttttc     5580

tgtatcgtat ttattatgca caaaaataaa gtgtgatctc taatagcatg gctaaaggta     5640

atgccaatat tagtgaatag ctttgctgtg ggctttatca ggcccttgtt tttcacagtg     5700

ttgtttgtac tccatggtgt attgctatta gagctgtgaa atgaaagctg tgactttatg     5760

aagagatcaa aaaaagtgtg gtccagattc aggtaggttg tggtaagttc agggaagtct     5820

tgtatgattt ctaagaatat ttcagttacc atgtatagta tttgggaaaa gctgtaatgt     5880

aaaatattgg actttgttgc aagataggta tatacttgtg tcagataatt aaagccttaa     5940

attttgaaat gaatctttga gatttcaaag aaagactgac ctttcaaata gaaggcggtc     6000

tttctattct agctaatgcc ccacttcttt aagttataaa caaagtttca tgataccatt     6060

ctgctatcat ctaaactttg ctgaactcta ctgccaacct acattaaaaa caaagtccca     6120

cgaaatggct gtgttacacc atagtgagca gaaacttaaa ttttgttcta attttgatgg     6180

ttgaaaaatt tcaacctgta gcaataaa                                        6208


<210> 652
<211> 1872
<212> DNA
<213> Homo sapiens

<400> 652
gaataaacac cgggtgccta gaggagaaga gatggagccc cagccttggt cccctttccc       60

acccttcctc cccacaaggc tgtctgagat gccaccttcc acctaaacat catctcccaa      120

attttaatcc ttaactttgg tctctgactt ctgcttgatt ccacagtctc cacccacatt      180

tgcacaaagg accatcacct gtccttcctg gaatctctaa agttttctgc tttccttctg      240

tcctgatggc cagctctgct aagtcagctg agatgcccac catctccaaa accgttaacc      300

ctactcctga tcctcatcaa gaatatctgg accctaggat taccattgcc ttattcgaaa      360

ttggatcaca ttccccttcc tcctggggct ctctcccttt cctaaagaat agcagccatc      420

aagttacaga acaacagact gcacagaagt ttaacaatct cttaaaagaa attaaagata      480

ttcttaaaaa tatggcaggt tttgaagaga agatcacaga agcaaaagaa ctttttgagg      540

aaaccaatat tactgaggat gtgtcagccc acaaagaaaa tatcagagga cttgacaaaa      600

tcaatgaaat gttatcaaca aacctgcctg ttagtttagc cccagagaaa gaagacaatg      660

aaaagaaaca ggagatgata ttggaaacca atattactga ggatgtgtca gcccacaaag      720

aaaatatcag aggacttgac aaaatcaatg aaatgttatc aacaaacctg cctgttagtt      780

tagccccaga gaaagaagac aatgaaaaga aacagcagat gataatggaa aaccagaact      840

ctgagaacac cgcacaagtt tttgcaagag atttggtaaa tcgtttagaa gaaaaaaaag      900

tccttaacga aactcaacaa agtcaggaaa aagcaaaaaa cagacttaat gttcaagaag      960

aaactatgaa aattaggaac aacatggagc agttactaca ggaagcagaa cactggagta     1020

aacaacatac tgagctcagt aaactgataa aatcctatca gaaatctcag aaagacataa     1080

gtgaaactct tggaaataat ggagtcggtt tccaaaccca gccaaataat gaagtgtcgg     1140

ctaagcatga gctggaggaa caggtgaaga aactgagcca tgacacctat tcattgcagt     1200

tgatggcagc tttgctagag aatgaatgcc aaatcttaca gcagagagta gagattctca     1260

aggaactcca tcatcagaaa cagggaactc tgcaagagaa gccaattcag ataaactata     1320

aacaggacaa gaaaaatcag aagccatcag aagcaaagaa agtagaaatg tataagcaga     1380

acaagcaagc aatgaagggt acattttgga aaaaagacag atcctgtaga agcctggatg     1440

tttgtcttaa taagaaagct tgcaataccc agttcaatat tcatgttgca agaaaagctc     1500

ttaggggaaa aatgaggtca gctagcagcc taagatagaa aataccaaaa gcagatgaaa     1560

aggtgaatcc ttaaaaaact acatctgtta cctccaactt gtcagtcatg atcaatcatc     1620

aaaccttggg cagatctgct ggttcaacca agaaagagct atagaataag gagattgaca     1680

cttatattac tcattacttc agcagttatg taagtctggt ctttaatgac cattgtgtct     1740

acatcaagtt cataactttt cacctttaca atctgcttgt tttttttgta attattagat     1800

agacagccta gagtgagaag ttaaaggtcc aattaagtaa agatctaaat aaaaaccaga     1860

atacaaggga aa                                                         1872


<210> 653
<211> 7505
<212> DNA
<213> Homo sapiens

<400> 653
gttgtgactg aaacccgtca atatggcggc gatcggccgc ggccgctctc tgaagaacct       60

ccgagtacga gggcggaatg acagcggcga ggagaacgtc ccgctggatc tgacccgaga      120

accttctgat aacttaagag agattctcca aaatgtggcc agattgcagg gagtatcaaa      180

tatgagaaag ctaggccatc tgaataactt tactaagctt ctttgtgata ttggccacag      240

tgaagaaaaa ctgggctttc actatgagga tatcataatt tgtttgcggt tagctttatt      300

aaatgaagca aaagaagtgc gagcagcagg gctacgagcg cttcgatatc tcatccaaga      360

ctccagtatt ctccagaagg tgctaaaatt gaaagtggac tatttaatag ctaggtgcat      420

tgacatacaa cagagcaacg aggtagagag gacacaagca cttcgattag tcagaaagat      480

gattactgtg aatgcttcct tgtttcctag ttctgtgacc aactcattaa ttgcagttgg      540

aaatgatgga cttcaagaaa gagacagaat ggtccgagca tgcattgcca ttatctgtga      600

actagcactt cagaatccag aggtggtggc ccttcgaggt ggactaaaca ccatcttgaa      660

aaatgtgatc gattgccaat taagtcgaat aaatgaggcc ctaattacta caattttgca      720

ccttcttaat catccaaaga ctcgacagta tgtgcgagct gatgtagaat tagagagaat      780

tttagcaccc tatactgatt ttcactacag acatagtcca gatacagctg aaggacagct      840

caaagaagac agagaagcac gatttctagc cagtaaaatg ggaatcatag caacattccg      900

atcatgggca ggtattatta atttatgtaa acctggaaat tctgggatcc agtctctaat      960

aggagtactt tgcataccaa atatggaaat aaggcgaggt ctacttgaag tgctttatga     1020

tatatttcgt cttcctctac ctgttgtgac tgaggagttc atagaagcac tactcagtgt     1080

agatccaggg aggttccaag acagttggag gctttcagat ggctttgtgg cagctgaggc     1140

aaaaactatt cttcctcatc gtgccagatc caggccagac ctcatggata attatttggc     1200

actgatactc tctgcattta ttcgtaatgg acttttagag ggtctagttg aagtgataac     1260

aaacagtgat gatcatatct cagttagagc taccatcctt ttaggagagc ttttacatat     1320

ggcaaacaca attcttcctc attcacatag ccatcattta cactgcttgc caaccctaat     1380

gaatatggct gcatcctttg atatccccaa ggaaaagaga ctgcgagcca gtgcagcctt     1440

gaactgttta aaacgcttcc atgaaatgaa gaaacgagga cctaagcctt atagtcttca     1500

tttagaccac attattcaga aagcaattgc aacacaccag aaacgggatc agtatctccg     1560

agttcagaaa gatatattta tccttaagga tacagaggaa gctcttttaa ttaaccttag     1620

agatagccaa gtccttcaac ataaagagaa tcttgaatgg aattggaatc ttatagggac     1680

cattcttaag tggccaaatg taaatctaag aaactataaa gatgaacagt tacacaggtt     1740

tgtacgaaga ctactttatt tttacaagcc cagcagtaaa ttatatgcca acctggatct     1800

ggattttgcc aaggccaaac agctcacggt tgtaggttgc cagtttacag aatttcttct     1860

tgaatctgaa gaggatgggc aaggctactt agaagatcta gtaaaggata ttgttcagtg     1920

gctcaatgct tcatctggaa tgaaacccga aagaagtctt caaaataatg gtttattgac     1980

cacccttagt caacactact ttttatttat tggaacactt tcttgccacc ctcatggagt     2040

taaaatgctg gaaaaatgca gtgtatttca gtgtctcctt aatctttgct ccttgaaaaa     2100

ccaagatcac ttgctaaaac ttactgtttc tagcttggac tatagcagag atggattggc     2160

tagagtcatc ctttccaaaa ttttaactgc agctactgat gcctgcagac tctatgcaac     2220

aaaacattta agggtattat tgagagctaa tgttgaattc tttaataatt ggggaattga     2280

gttgttagtg acccagctac atgataaaaa caaaacgatt tcctctgaag ctcttgatat     2340

cctcgatgaa gcatgtgaag acaaggccaa tcttcatgct ctcattcaga tgaaaccagc     2400

gttatcccac cttggagaca agggtttgct tctcctgctg agatttctct ccattccaaa     2460

aggattttcc tatctgaatg aaagaggtta tgtagcaaaa caattggaaa agtggcacag     2520

ggaatacaac tccaaatatg ttgacttgat tgaggaacaa ctcaatgaag cacttactac     2580

ttaccggaag cctgttgatg gtgataacta tgttcgtcgg agtaaccaaa gattacagcg     2640

tcctcacgtc tacctgccta tacaccttta tggacaacta gtacaccata aaacaggctg     2700

ccatttgttg gaagtacaga atattattac agaactctgt cgtaatgttc gtacaccaga     2760

tttggataag tgggaagaaa ttaaaaaact gaaagcatct ctttgggcct tgggaaatat     2820

cggctcatca aattggggtc tcaatttgct acaggaagaa aacgtgattc cagatatact     2880

aaaacttgca aaacagtgtg aagttctttc catcagaggg acctgtgtat atgtacttgg     2940

gctcatagct aaaaccaaac aaggctgtga tattctaaaa tgtcacaact gggatgctgt     3000

gaggcatagt cgcaaacatc tgtggccagt ggttccagat gatgtggaac aactctgtaa     3060

tgaactttca tctatcccaa gcactctaag tttgaactcg gagtcaacca gctctagaca     3120

taatagtgaa agtgaatctg tgccatcgag tatgttcata ttggaggatg accggtttgg     3180

cagcagctct actagcacat ttttccttga tatcaatgaa gatacagagc caacatttta     3240

tgaccgatct ggacccataa aggataaaaa ttcattccct ttctttgctt ctagtaaact     3300

tgtgaagaat cgtatcttaa attcgcttac tttgcctaac aaaaaacatc gtagtagcag     3360

tgatccaaaa ggagggaaat tatcatctga aagtaagaca agcaacaggc gaatcagaac     3420

acttacggag cccagtgttg attttaatca tagtgatgat tttacaccca tatccactgt     3480

acagaaaaca ttacaattag agacttcatt tatggggaat aagcacattg aagacactgg     3540

tagtacacca agcattggag aaaatgactt aaaattcacc aagaattttg gtacagagaa     3600

tcacagagaa aatacaagcc gagagaggtt agtagtagaa agttcaacga gctcacatat     3660

gaagatacgt agccaaagtt tcaatacaga cactacaaca agtggcataa gttcaatgag     3720

ctcaagtcct tcacgagaga cagtaggtgt agatgctaca actatggaca cagactgtgg     3780

aagcatgagt actgtggtaa gtactaaaac tattaagaca agccactatt tgacgccaca     3840

gtctaaccat ctgtctctct ccaaatcaaa ttcggtgtcc ctggtgcctc caggttcttc     3900

tcatacgctt cctagaagag cacagtccct taaagcaccc tctattgcta caattaaaag     3960

tctagcagat tgtaacttta gttacacaag ttctagagat gcttttggct atgctacact     4020

gaaaagacta cagcaacaaa gaatgcatcc atccttatct cactctgaag ctttggcatc     4080

tccagcaaaa gatgtgctat ttactgatac catcaccatg aaggccaaca gttttgagtc     4140

cagattaaca ccaagcagga tcgattttaa aaagaagcat gtcgggggaa tcaggagctt     4200

aagacctaca ataacaaaca accttttcag gttcatgaaa gccttaagtt atgcatcatt     4260

agataaagaa gatttattga gtcctattaa tcaaaatacc ctgcaacgat cttcctcagt     4320

gcggtccatg gtgtccagtg ccacatatgg gggttcagat gattacattg gtcttgctct     4380

cccggtggat ataaatgata tattccaggt aaaggatatt ccctattttc agacaaaaaa     4440

cataccacca catgatgatc gaggtgcaag agcatttgcc catgatgcag gaggtcttcc     4500

atctggaact ggaggtcttg taaaaaattc ttttcacttg ctacgacagc agatgagtct     4560

tacggaaata atgaattcaa tccattcaga tgcctctctg tttttagaaa gtacagaaga     4620

cactggacta caggaacata cagatgataa ctgcctttat tgtgtctgta ttgaaattct     4680

gggtttccag cccagcaacc aactgagtgc aatatgtagt cattcagact ttcaagatat     4740

tccatattct gattggtgtg agcagactat ccataatcct ttagaagtgg ttccctctaa     4800

gttttcgggg atttctggat gcagtgatgg ggtgtctcaa gaaggctcag ctagcagcac     4860

caaaagcaca gaattgttac taggtgttaa aacaattcca gatgatacac caatgtgccg     4920

tatactcctt cgcaaagaag ttctaagatt agtcattaat ttgagtagtt cagtttcaac     4980

taaatgtcat gagactgggc ttttaacaat taaggagaag tatcctcaaa catttgatga     5040

catatgcctt tactctgagg tttcccattt gctgtcacac tgcacattca gacttccgtg     5100

tcggaggttc atacaagaat tatttcaaga tgtacagttt ctacaaatgc atgaagaagc     5160

agaggctgtg ttggcaacac caccaaagca acctatagtt gatacatctg ctgaatcctg     5220

acctcatatt tatgatggat atagatacat actatatata ttcatatttg tggatttcct     5280

aaaagcctca gaaaatacga ctgactaggc agcaaagaca ggagtatctt ctgtacactg     5340

ttccgcagtt actggtacat gaacagttgg aactgctgac tttcctaacc aaaacaactt     5400

ccttctctcc tttgttgagc cttttgaggg gttcatgatt cattaccaca gttttaagag     5460

tttcagttac cattgtatgc aagagccaag cactgaatac ctacataggt tttctatttt     5520

ctttcatttt aaaagcataa tgacagtgga acaataatgg gatatgcaga agcacccttc     5580

acaagttatt tctgaatgat ttttagggta aataatacag atgccttgtt tgttaactaa     5640

cttgtggaaa gcaggaatca gtgtctctaa ggctgcatcc tattaccaca atggggtgtg     5700

ctataactgc tggtattaga gagggaactt tggccctttc acgtttttct taatgtttgt     5760

aacactactt cagaggttta taacctcaaa gcagaagaag agcctcaaca acccgggact     5820

tataagttat ttttatgtta ctagacttgc ataaagattc ttgttttcca actcttcatt     5880

ttgttgcaat gtgttattac aggatatatg aaccaattaa ggtttttcac tacagttctt     5940

gaataaaatt taaaaatcat tttttatttt aattaaaaat atttcccatt tatagaatgc     6000

atatatttgc aatggacttc cactttcatc aactttccat ctcatcgctt taaacaggaa     6060

cttgaacaag cactgttagt ttagacctaa aggataggaa agcattaaat aatactttgg     6120

atctcctgag gaaaagataa gtttgcttgc aatttacaca ttccatgggg aaagaagagc     6180

catatttcct taaaaaaaac attaataaag cttgttattg agaaaaattg tagtgaaaag     6240

ccttaagtac caaattttaa agcagcagta acttaatttt tatatcagtg tttttgtttt     6300

gcacaaacta aatgcagtgg taggtgggtt tatgagtata ttaattgcct ttatccattt     6360

gtgaagttaa gttgatgagg gcaaggtttt tgtttgttta atttgtatat gtctaaaggt     6420

atttggaact ttttacagga attaaacata tatgcaaatt tgtatataaa aatagcatgg     6480

ccatcatttg aatgcttgta aatgaaagga ttatcttttt tgagatctat atataaatag     6540

aaatagaaaa tccagctgga ctgattagga ttctttttta attcatttgt gtataacatt     6600

tttattacaa ttacacatca gttttgacac agtcatagca acattaatat tttcccatga     6660

tgcagatcct ttttgtaatg ggcttgttct ttgagatctc tgtaaagaac cctgtgaact     6720

agaaaacata actcacagag atactttttt aaaaaattta tttactggaa ctgaaagttc     6780

cagttgggat gaagcatttc atctcacttc ataacacctc tttgactgca cttcagtgaa     6840

ttgttcttat gtgcactgtg tagcaactta cattataaca aagcagataa gggctgtaag     6900

ctgctgctta tgttgaaaag tggttcttca gattttctct cataaaatcc agttgaagat     6960

aaataatttt tttatacttt atcactgaac ccaagtgttt atttaaatgt caacagtact     7020

tctaagaacg ttgcctgtca tcgtggtctt tggtcttgga taactaaact gcctttccag     7080

agaaccaaat gtcagagtta ctagaccaaa tagtggttaa aacctccaaa ggaagtaatg     7140

taatcttatt cataatggga ttaacatatt ttagacattc attttaaaca ctacctcagt     7200

taatatagag tataaaaatc tgtggtttaa tccctcaaaa gttaacagta attttttttt     7260

tgtcttacac acacacacac cccctccccc accatcacta tccctgtacc ctcaccttgg     7320

tcatctatcc tgaaataagg cttagttagt attggcctga atgttttgtg tttttttttt     7380

tgtttttttt ttttactgtt actttgaaaa atatgtatgt ataccttatc atatctgcct     7440

atatcactta ctttggggag atactcagag ctttgtggtt atcagtatac taaaaaaaaa     7500

aaaaa                                                                 7505


<210> 654
<211> 3793
<212> DNA
<213> Homo sapiens

<400> 654
tagtcccctg gtgaggctta agctcttgtc tgttctggtc tttttttttt ttttttaact       60

tcctaaaatt ctccgattct aaaagaaagc tcctaaatag aagccaaaaa gtagccgccc      120

aacttgaaac tccccacaag ccgggtaaat agcgcgatac gcagcagcta gagttctcgc      180

gtttcccacg gcgcaggagc actggagggc ccccctccgc ccccggcccc gccaggaaat      240

tagtgcgcat gtgccggtca tccggaagtt accgcagtgg ccgccggaat taggcgaaaa      300

gccggaagta aacattacga gattggcttg gattctgtcg gatggacttg gggctagctg      360

cggcggggct ggaggaggcc agataaccat gtcagccaca gttgtagatg cagttaatgc      420

tgcaccccta tcggggtcca aagaaatgag tttggaagaa ccaaagaaga tgaccagaga      480

ggactggaga aagaagaagg agctagaaga acagcgaaaa ttgggcaatg ctcctgcaga      540

agttgatgaa gaaggaaaag acatcaaccc ccatattcct cagtatattt cttcagtgcc      600

atggtatatt gatccttcaa aaagacctac tttaaaacac cagagaccac aaccagaaaa      660

acaaaagcag ttcagctcat ctggagaatg gtacaagagg ggtgtaaaag agaattccat      720

aattactaag taccgcaaag gagcatgtga aaattgtggg gccatgacac acaaaaagaa      780

agactgcttt gagagaccta ggcgagttgg agccaaattt acaggtacta atatagctcc      840

agatgaacat gtccagcctc aactgatgtt tgactatgat gggaagaggg atcggtggaa      900

tggctacaat ccagaagaac acatgaaaat tgttgaagag tatgccaaag ttgatttggc      960

aaaacgaaca ttgaaagccc agaaactcca agaggaatta gcctcaggaa aattagtgga     1020

acaggctaat tctccaaaac accagtgggg agaagaggaa ccaaattctc agatggaaaa     1080

agatcataat agtgaagatg aggatgaaga taaatatgca gatgatattg acatgcctgg     1140

acagaatttt gactccaaga gacgaattac tgtccggaat ctcaggattc gagaagatat     1200

tgcaaaatat ttgaggaatt tagatccaaa ttctgcctac tatgatccaa aaactagagc     1260

aatgagagag aatccttatg ccaatgcagg aaagaatcca gatgaagtga gttatgctgg     1320

agataacttt gttaggtaca caggagatac catttcaatg gctcagacac agttgtttgc     1380

atgggaagcc tatgacaagg gatctgaagt gcatctacag gcagatccta caaagctaga     1440

gctgttgtat aagtccttca aagtcaaaaa agaagatttc aaagaacagc agaaagaaag     1500

catcctggaa aagtatggtg gccaagaaca tttggatgcc cctccagctg aattgctttt     1560

agcccagact gaagactatg tggagtactc aagacatggg acagtcatca aaggacagga     1620

gcgggctgtt gcctgctcta agtatgagga ggatgtgaag atccacaatc acacacatat     1680

ctggggatcg tactggaaag aaggccgatg gggatacaaa tgctgtcact cttttttcaa     1740

gtattcctat tgtactggag aagctgggaa ggagattgtt aactctgagg agtgtattat     1800

aaatgagata actggggaag aatctgtgaa aaaacctcaa accctcatgg agctgcatca     1860

agaaaaactg aaagaggaaa agaagaagaa gaaaaagaaa aagaagaagc atcgaaagag     1920

cagttcagat agtgatgatg aagaaaagaa gcatgaaaaa ttgaaaaagg cactgaacgc     1980

agaggaggcc cgccttcttc atgtcaagga gaccatgcag attgatgaga ggaagcggcc     2040

ttacaatagc atgtatgaaa ctcgagaacc tactgaagag gaaatggagg catatagaat     2100

gaaacgtcag aggccagatg accccatggc ctctttcctt ggacagtagc aactagtcag     2160

aagaccatcc aagatagatg cagctgatac attcttttca gcttcttatt gatgattgta     2220

gatagaaaaa tccttgttta ttcttcttgc tgcctggctt taataaatat ttcagatgcc     2280

tcacagtaag ttcactcctt tccatactga ggaaacaaga aaagaagaag aggcacatga     2340

agtgtgcttt tgggaataga atttaaaatt ggattaagat tttatttcca gtttttttta     2400

tttatttatt tttttttttg agacggagtc ttgctctgtc gcccaggctg aagtgcggtg     2460

gcgcgatctc ggctcactgc aagctccacc tcccaggttc acgccattct cctgcctcag     2520

cctccctagt agttgggact acaggcgccc gccaccatgc tcagctaatt ttttgtattt     2580

ttagtagaga cggtttcatc gtgttagcca ggatggtctc gatctcctga ccttgtgatc     2640

cacccgcctc agcctcccaa agtgctgaga ttacaggcgt gagccaccgc gcctggccta     2700

tttccagttt tatgtgagtc atgtaaaaaa gccttggctc tctacctatt aagaatgtct     2760

ctttctctgt atttattaag cttcaaactt tattgcttcg atttttgtgg ccctatattt     2820

agtattagca caccttggtt ttgagaaaaa aacagggctt tgttttttta aataattact     2880

agcaactctg tgactacatt tatttttatt ttttttagag acaggatctt gctatgttgc     2940

ccaggctaga gagcagtggc ttttcacaga caaagtcata atgccctgca gtcttgggct     3000

caagcgattc tctcttcctt ggcctctgga gtagactaaa tgtgttagtc tttgaatgga     3060

aaacaactat tttctcatca ttgggtcaat attgactgat cagtagtagg tcttttacca     3120

ttctggacat aagtctaggt gtagaaatcc tttcctttat catagaggat atggtttaca     3180

ttaccgtttg ttttcattgt gattgcccct atgtaacaat catgaatatt agatttttta     3240

aattgtagaa tatcctaata tttatagcca gcagctgtta ctttgtttgt aaaatttgca     3300

aaaaaacaaa acctgaagtt ggtttattga aagaattata aggatagctt ctagggatat     3360

tagtaataga ttgccatgat cctgaagcct cttctcagaa cactgtgaag ataatactga     3420

cagtagaatc agtgaaaaca gcctaacaaa acctctgaca tcagtatatc aacttttaac     3480

agcccactca ctggcttttc taaactacca aaaaccacct gtaggatact gcattaagtc     3540

agcatctcag aaacagtggt gtgagtaact gagtcaaatt gtcaagtact ttggatatac     3600

atagtgtcga gctttagatt ggtatgaaat taaacagcaa tgcaaataga tttaattcct     3660

atttacttta agaatgaaaa acaatgttca ttttcctacc taaacagggt ggttcaacat     3720

aaaggctgat gttgtgtccg ttttgtattt tatcttttgt taaagataca taaatgacaa     3780

tacttaactg tga                                                        3793


<210> 655
<211> 4288
<212> DNA
<213> Homo sapiens

<400> 655
gctggcgagt gtaccctttc tgcagaaagt aaaaatggcc ttattcagta agttaaattt       60

atgttgctat ttctttacga caccggaaaa caaacatttc aaacaccatg ctgagaactc      120

agtccttgtt ttggggaggg atgcacttgg aagattcgag ctaaggtaca atcctcccta      180

ggtatccgcg ggtcattgtt ttcaggaccc ccacagatac caacatccgc catgctcaag      240

ccccttacat tatgtggggg tgcacggtgg gtccttccca tccgcaggtt cggcatccgt      300

ggatggggag tggatacaga gggcggacta tacagcttga aaggcttccc tggaagcaat      360

atgtagagtg gattgtggag gagcaagaac agaagcgggg aggcttgtcc agagcataca      420

ggggaaggat gtacggccaa gggaggaatc ccagacgacc gcgatacgtg acatatttat      480

gtttgcacga aaataaagtt tggaagaaaa gtgttggggg aacaagggat tcattttccc      540

ggggtagttg gaatgcaatg ggacgcctca ggccgctggg acaggctggc ctccgcgcgg      600

gggcgcccga gcagccgagc cgccgggcct tccggctgcc ccgccggaag tgctctcctg      660

acccgccgct gtgcagcgca gcgcaccgcg ggaagatggc gttggaggtc ggcgatatgg      720

aagatgggca gctttccgac tcggattccg acatgacggt cgcacccagc gacaggccgc      780

tgcaattgcc aaaagtgcta ggtggcgaca gtgctatgag ggccttccag aacacggcaa      840

ctgcatgtgc accagtatca cattatcgag ctgttgaaag tgtggattca agtgaagaaa      900

gtttttctga ttcagatgat gatagctgtc tttggaaacg caaacgacag aaatgtttta      960

accctcctcc caaaccagag ccttttcagt ttggccagag cagtcagaaa ccacctgttg     1020

ctggaggaaa gaagattaac aacatatggg gtgctgtgct gcaggaacag aatcaagatg     1080

cagtggccac tgaacttggt atcttgggaa tggagggcac tattgacaga agcagacaat     1140

ccgagaccta caattatttg cttgccaaga aacttaggaa ggaatctcaa gagcatacaa     1200

aagatctaga caaggaacta gatgaatata tgcatggtgg caaaaaaatg ggatcaaagg     1260

aagaggaaaa tgggcaaggt catctcaaaa ggaaacgacc tgtcaaagac aggctaggga     1320

acagaccaga aatgaactat aaaggtcgat acgagatcac agcggaagat tctcaagaga     1380

aagtggctga tgaaatttca ttcaggttac aggaaccaaa gaaagacctg atagcccgag     1440

tagtgaggat tattggtaac aaaaaggcaa ttgaacttct gatggaaacc gctgaagttg     1500

aacaaaatgg tggtctcttt ataatgaatg gtagtcgaag aagaacacca ggtggagttt     1560

ttctgaatct cttgaaaaac actcctagta tcagcgagga acaaattaag gacattttct     1620

acattgaaaa ccaaaaggaa tatgaaaata aaaaagctgc taggaagagg agaacacaag     1680

tgttggggaa aaagatgaaa caagctatta aaagtctaaa ttttcaagaa gatgatgata     1740

catcacgaga aacttttgca agtgacacga atgaggcctt ggcctctctt gatgagtcac     1800

aggaaggaca tgcagaagcc aagttggagg cagaggaagc cattgaagtt gatcattctc     1860

atgatttgga catcttttaa gtacattttc aacagtttga ggactaagcc tttctaaaat     1920

aacattgtaa taaaccattt ttactgagat tgcaacgttt tgcactgata aacatgagaa     1980

tctggaggaa agacaattgt tttcttgttt aaaatatgtg tggaaaggaa tgcaattgat     2040

agaacattta aagatatatc tgacaaaata cttaagagta tatagcacag gatttaattt     2100

ctcaatctgt tgcatgtgct aattatgagt attactagtt gataatcagt tttgtctagg     2160

tcataacata ccatttgtaa gtttgtttgc tttttcaggt ttatctttgc agtgaattat     2220

gctttgcttt aaaacattcc gctaaaatca taatgggaca tataaattat taagctgtta     2280

gaaatgcatt caaatttgtt ttttctgtgt tctaagaact caggcaattt taaggataaa     2340

aactaacatt ggccaggcac ggtggctcac gcctgtaatc ccaacacttt aggagaccaa     2400

ggcgggcaga tcacttgagg tcagaagttt gagaccagcc aggccaacat ggtgaaactt     2460

catctctact aaaaatacaa aaactagcca ggtgtggttc tccatgccta taatcccggc     2520

tactcgggag gctgaggcag gagaatcacc tgaacccggg aggcaaaggt tgcagtgagc     2580

tgagatcgta ccactgtact ccagcctggg cgacagagca agactctgtc tcaaaaaaaa     2640

aaaaaaatac aattaagagg tgtatactga tgattcttcc cactcatttg tttgtccaga     2700

agtaaataaa tgtcggaagt tttccaagta actatttgtt ttttgggggg ttttttagtt     2760

agagtcttga tctgtcaccc aggctggagt acagtggcag gatctcagct tactgcagct     2820

tccatctccc aggttcaagc gatcatgtgc ctaagcctcc tgagtagctg ggatcacagg     2880

tgtgtaccac cacgcccagc tgatttttgt atttttagta aagactttcg ccatgttgtc     2940

caggctggtc tcgaactcct ggcctaatga tctgcccacc tctgcctccc aaagtgctgg     3000

gatcacaggc atgagccacc gaacccagcc ttattctgct taaatttaac gtgttttttg     3060

acttcttaat taacttggtc atatactaaa tgtgatctcc tgtggattac cacatgcatt     3120

aaaaaatttt tcaagctggg cctagtggcg cacacctgca atcccaacac tttgggaggc     3180

caagagagga agattgcttg agcccaggag tttgagacca atctaggcaa tgtagtgaga     3240

ccctgtctct aatttaaaaa agaaaaagaa aaaaacattc ccagtggcag cctgcctaag     3300

actgtcttac cttatgttaa ggaagtcagg tatttaaaat gttacatatg ccggcgcagt     3360

ggctcatgtg tgtaatccca gcactctggg aggctgagac aggtagatca tttgaggtca     3420

ggagttcaaa accaacctgg tctacatggt gaaaccccat ctcaactaaa aatacaaaaa     3480

atacaaaaaa ttagccgggc gcggtggctc acacctgtaa tcccagcact ttgggaggtg     3540

gaggcgggtg gatcacaagg tcaagagatc gagaccatcc tggccaacat ggtgaaaccc     3600

tgtctctatt aaaaatacaa aaattagctg ggcgtggtgg cgcatgcctg tagtcccaac     3660

tactagggag gctgaggcag gagaatcact tgaacccagg aggtggaggt tgcagtgagc     3720

cgagatcacg ccactgcact ccagcctggc gacagagcga gactccctct caaaaaaaaa     3780

aaaaaaaata caaaaaatta gccgggcatt gtggtgcatg cctgtaatct cagctatttg     3840

ggaggccgag gcaggagaat cacttgaacc caggaggcag aggttgcagt gagtcgagat     3900

cgtgccactg cactccagcc tgggtgacag agcaagactt tgtctcaaaa ataataatag     3960

taaaatgtta catgtgcatg aagttttaaa ttactcattt ttattaatga agaaaataag     4020

gtagtttaga cattccaaga gttaactata gtttacaaaa atatattaag caaaaatatg     4080

cttgatatat taagcagaaa tgttgtatat taagcaaaaa tgtaaaattc agcaattata     4140

aactgttcct tacagacagt gtacttgaag tcttttggta gttctgagaa tgtggtcatt     4200

gaagttggat ctaagaggaa agtggttatc ggttgctttt tatttataaa ggatgcaaaa     4260

ataaaattag atttttggca gtccttaa                                        4288


<210> 656
<211> 1151
<212> DNA
<213> Homo sapiens

<400> 656
ggagggggca tcagtgtggg gtgggagcag gaaggctgtt ggggaaggaa gctgagagat       60

cctctgcagg aggggattat agcagctaag ggcacctgcc aggctggagg tgtggcctgt      120

ctaggggaag ggtggtcact gatgtccagc aggagccctt gacaggtaga gcccaccacg      180

gcatctccaa gaccacacca tgttcctgtt ctcccgtaag accaggaccc ctatcagtac      240

ctacagtgac tcctacaggg ctcccacctc catcaaggag gtctataagg acccacccct      300

gtgtgcctgg gaagccaaca agtttctgac tccgggtctg actcatacca tggagcgaca      360

tgtggatccc gaagccctgc agaagatggc caaatgtgct gtacaggact acacttatag      420

ggggtccata tcaggccacc cctacttgcc tgagaagtac tggctttctc aagaggaagc      480

agacaaatgc agcccaaact acctgggcag tgactggtac aacacatgga ggatggaacc      540

ttacaacagc agctgctgca acaagtatac cacctacctt cctcggctgc ctaaggaggc      600

caggatggag acagcagttc gaggaatgcc cttggaatgc cctcctaggc cggagcggct      660

caatgcctac gagcgcgaag tgatggtgaa catgctgaac tcactgtcgc ggaaccagca      720

gctgccgcgg atcacgcccc gatgcgggtg cgtggacccg ctgcccggcc gcctgccctt      780

ccatggttac gaaagtgctt gctcgggccg ccactactgt ctgcgcggga tggactacta      840

cgccagcggg gcgccctgca ccgaccgccg cctgcggcct tggtgccggg agcaaccgac      900

tatgtgtacc tccctacgag caccggcccg gaatgcagtg tgctgttaca actcccccgc      960

cgtcatacta cccatatccg aaccttagat gggacacaag tcacttcaag aagtctggtg     1020

gtccccagag aaacaactat gttatccatc ctgagtttgt gtctgagacc tatcccgact     1080

atcgttgctg gtagagcctg ggcttgctgt gccaaggggg cagagcaata aataaactct     1140

tcaaccccaa a                                                          1151


<210> 657
<211> 4653
<212> DNA
<213> Homo sapiens

<400> 657
agagcgaagc tgaggagtcc agcgctcgcc gacaggggcc tgggctgtcc cgagccggaa       60

tccagatctt acataagatg gaagtctctc acactagata ctgaacatta aatagaaaat      120

ctatttagta aaatctaagt tgccatggaa gaaataccag taaaagttgc tgtaagaatt      180

agacctctgc tttgcaaaga agctcttcat aatcatcaag tttgtgtgag agttattcca      240

aacagccagc aagttatcat tgggagagat agagtcttca cttttgattt tgtttttggc      300

aaaaattcca ctcaagatga agtttataac acatgtataa agcccctagt gttgtcactc      360

attgagggct ataatgcaac tgtttttgcc tatggacaaa ctggatctgg gaagacatac      420

accattggag ggggccatat tgcttcagtt gtggagggcc aaaagggtat cattcctcga      480

gctattcaag aaatatttca aagcatctct gaacatccta gcattgactt taatgtaaaa      540

gtatcttata tagaagtgta caaggaagac ctaagagatc ttctagaatt ggagacatcc      600

atgaaggatc ttcacatccg agaagatgaa aaaggaaaca cagtgattgt tggggccaag      660

gaatgccatg tggagagtgc aggtgaagtg atgagtcttt tggagatggg gaatgcagcc      720

agacatacag gtaccactca aatgaatgag cactccagca gatcacatgc aatttttaca      780

atcagcattt gtcaagttca taaaaatatg gaggcagctg aagatggatc atggtattcc      840

cctcggcata ttgtctcaaa gttccacttt gtggatttgg caggatcaga aagagtaacc      900

aaaacgggga atactggtga acggttcaaa gaatccattc aaatcaatag tggattgctg      960

gctttaggaa atgtaataag cgctcttggg gacccacgca ggaagagttc acatattcca     1020

tatagggatg ctaaaattac ccggcttctg aaagattctc tgggaggcag tgctaagact     1080

gtcatgatca catgtgtcag cccctcctcc tcgaattttg atgagtcctt aaattctctc     1140

aaatatgcca acagagcacg gaacattaga aacaaaccca ctgtaaactt cagccccgag     1200

tcagaccgta tagatgaaat ggaatttgag attaaattgc ttcgagaagc tttgcaaagc     1260

cagcaggctg gtgtcagcca aactacccag atcaatcgag aagggagtcc tgatacaaat     1320

aggattcatt ctcttgagga gcaagtagct cagcttcaag gagaatgtct gggttaccag     1380

tgttgtgtag aagaagcctt taccttcctg gttgacctaa aagatactgt cagactaaac     1440

gaaaagcagc aacacaaact gcaggagtgg tttaacatga tccaagaggt caggaaggct     1500

gtcctcacct catttcgagg aatcggaggc actgcaagtc tggaagaagg accacagcat     1560

gttacagttc tccagctgaa gagagagctt aagaaatgcc agtgtgtgct tgctgctgat     1620

gaagtagtat ttaatcagaa ggaactggag gtgaaggaac tgaagaatca agtgcagatg     1680

atggtacagg aaaacaaagg gcatgctgta tctttgaaag aagcgcaaaa agtgaataga     1740

ctgcagaatg aaaaaataat agaacaacaa cttcttgtgg atcaactgag tgaagaacta     1800

acaaaactta acctgtcagt gacttcttca gctaaagaaa attgtggaga tgggccagat     1860

gccaggatcc ctgaaaggag accatatact gtaccatttg atactcattt ggggcattat     1920

atttatatcc catcaagaca agattccagg aaggtccaca caagtccgcc tatgtactct     1980

ctggatcgaa tatttgctgg atttcgaaca cgaagtcaga tgctgttggg tcacatagaa     2040

gaacaagata aggtcctcca ctgccaattt tctgataaca gtgatgatga agaatcagaa     2100

ggccaagaga aatctggaac tagatgtaga agtcgttcat ggattcagaa gccagactct     2160

gtttgttccc ttgttgaatt gagtgatact caggatgaaa cacaaaagtc agatttggag     2220

aatgaagatt taaagattga ttgtctccag gagagtcaag aattgaattt gcaaaaatta     2280

aagaattcag aacgcatact tactgaagct aaacaaaaaa tgagagaact tacaattaac     2340

atcaagatga aggaagatct gattaaagaa ttaataaaaa caggtaatga tgccaagtct     2400

gtaagcaagc agtattcttt gaaagtaaca aagctagagc atgatgcaga acaggcaaaa     2460

gtcgaactga ttgaaacaca aaagcagcta caggagctgg aaaacaaaga tctttctgat     2520

gttgcaatga aggtaaaatt acagaaagag tttcgtaaaa agatggatgc tgcaaagctg     2580

agagttcagg tcttgcagaa gaagcaacaa gatagtaaga aactggcatc actgtcaatc     2640

caaaatgaga aacgtgctaa tgagctagag cagagtgtag atcacatgaa atatcaaaag     2700

atacagctac aaagaaaact acgagaagaa aatgaaaaaa ggaagcaact ggatgcagta     2760

attaagcggg accagcaaaa aatcaaagaa atacaattaa aaacaggaca ggaagaaggt     2820

ctaaaaccga aagctgagga ccttgatgca tgtaacttga aaaggagaaa aggttcgttt     2880

ggaagtatag accatctcca gaaattggat gagcaaaaga aatggttaga tgaagaagta     2940

gagaaagttc tgaaccaacg ccaagaatta gaggagctgg aagcagactt aaagaaacgg     3000

gaggccatag tttctaagaa ggaggctctg ttacaggaga agagtcacct ggaaaataag     3060

aaattgagat ctagtcaggc cttaaacaca gatagtttga aaatatcaac tcgcctgaac     3120

ttactggaac aagagttgtc tgaaaagaat gtgcagctcc agaccagtac agctgaggag     3180

aaaacaaaga tttcagaaca agttgaagtc ctccagaaag aaaaggatca gctccagaaa     3240

cgcagacaca atgtggatga aaaacttaaa aatggtagag tgttatcacc tgaagaagaa     3300

catgttcttt tccaacttga agaagggatt gaagctttgg aagctgcaat tgaatacagg     3360

aatgaaagta tccagaatcg ccagaagtca cttagagcat cattccataa cctctctcgt     3420

ggtgaagcaa atgtcttgga aaagctagct tgcctgagtc ctgttgagat tagaactatt     3480

cttttcagat atttcaataa ggtggtgaat ttgcgagaag ctgaacggaa acaacagtta     3540

tataatgaag aaatgaaaat gaaagttctg gaacgggata atatggttcg tgaattagaa     3600

tctgcactgg accatctaaa attgcagtgt gaccggagac tgaccctcca gcaaaaggaa     3660

cacgaacaaa agatgcagtt gctattacat catttcaaag aacaagatgg agaaggcatt     3720

atggaaactt tcaaaacata tgaagataaa atccagcagt tggaaaaaga tctttatttc     3780

tataagaaaa ccagccggga tcataagaag aaacttaagg aactggtagg ggaagcaatt     3840

cggcggcaac tagcaccatc agagtatcaa gaggctggag atggagtcct gaagccagaa     3900

ggaggaggca tgctttcaga agaattaaaa tgggcatcca gacctgaaag tatgaaatta     3960

agtggaagag aaagagaaat ggacagttca gcaagcagct taagaacaca gccaaatcct     4020

caaaagctct gggaagatat cccagaatta cctccaattc atagttcttt agcacccccc     4080

agtgggcata tgttaggtaa tgagaataaa acagaaacag atgataatca gtttacaaaa     4140

tctcacagtc gactgtcatc ccaaattcag gttgtgggaa atgtgggacg acttcatggt     4200

gtcacacctg taaaactgtg tcgaaaagaa ttacgtcaaa tttccgcctt ggaactatca     4260

ttgcgacgtt ccagtcttgg agttggcatt ggatcaatgg ctgctgattc catcgaagta     4320

tctaggaaac caagggactt aaaaacttag acattgaata atagaacttt tagtagatat     4380

gtaaaaagat tcctttttct aacctgttaa aaactaaagc tcaagttcac tacctctttc     4440

ctcagaataa aggaagaagg ggaggaagga atccctaatt cttttatatg ctatagatgt     4500

gtacatcttc tatatatatt tggggagttt tagtttatat tcccatagta atcaaacatg     4560

ttttccaata cttgataaca tttaaatatt tataaatacg cttaaatgtt tttccaggca     4620

tatttgaaga ttaaaactag taatagacta aaa                                  4653


<210> 658
<211> 1008
<212> DNA
<213> Homo sapiens

<400> 658
ggagaagctg ggactagcag gcagtttttc atgatttttc ctcacactga tcactatcca       60

atcagaacaa taaacttcta acactccctt actaaaagaa catggttaag ggtgagaaag      120

gccccaaggg caagaagatc accctcaagg tggccaggaa ttgcatcaaa atcacttttg      180

atgggaaaaa gcgccttgac ttgagcaaga tgggaattac caccttcccc aagtgtattc      240

tgcgccttag tgacatggac gagctggacc ttagccggaa tcttatcagg aagatccctg      300

actccatctc caagttccag aacctccggt ggctggacct gcacagcaac tacatagaca      360

agctgcctga gtccattggc cagatgacca gcctgctcta cctcaacgtc agcaacaacc      420

ggctgaccag caacgggctg cccgtggagc tgaagcaact caagaacatc cgcgctgtga      480

acctaggctt gaaccacctg gacagcgtgc ccaccacact gggggccctg aaggagctcc      540

acgaggtagg gctccatgac aacctactga acaacatccc cgtgagcatc tccaagctcc      600

ccaagctgaa aaagctcaac ataaagcgga acccctttcc aaagccaggt gagtcggaaa      660

tattcataga ctccatcagg aggctggaga acttgtatgt tgtggaggag aaggatctgt      720

gtgcggcttg cctgagaaaa tgccaaaacg cccgggacaa cctgaataga atcaagaaca      780

tggccacgac gacaccgaga aagaccatct ttcccaatct gatctcaccc aattccatgg      840

ccaaggactc ctgggaagac tggaggtgac ttggaacctg accctgaggc agaagggaaa      900

gagagaggga gggaagaggg cagtgggcta cctccacagg aaaccaaggg ctcccctgtg      960

gctgcagcag ctctttcagc caagcccata aaactccttt ccttactt                  1008


<210> 659
<211> 807
<212> DNA
<213> Homo sapiens

<400> 659
ggacgagggg caacgtatat aaatgcgcgc aggcgtagtt aagagagcgc attttgactt       60

cgaggcaccg ccgacgttac tgtgtcgcca tggggcgccg tccagctcgc tgttaccggt      120

attgtaagaa caagccgtac ccaaaatctc gtttctgccg aggggttcct gatgccaaga      180

tccgcatctt tgacctgggt agaaagaagg caaaagtgga tgagttccca ctcggtggcc      240

acatggtgtc tgatgaatat gagcagctgt cttctgaagc cctggaggcc gcccgtattt      300

gtgccaacaa atacatggtg aaaagttgtg gcagagatgg ctttcacatg cgagtgcggc      360

tccatccctt ccatgtcatc cgcatcaaca agatgttgtc ctgtgctggg gctgacaggc      420

tccagacagg tatgcgaggt gcctttggaa aaccccaggg tactgtagcc cgggtccaca      480

ttggtcaagt catcatgtcc atccgcacca agcttcagaa cgaggagcat gtgattgaag      540

ccttgcgcag ggccaagttc aagttccctg gacgccagaa gattcatatc tccaagaagt      600

ggggcttcac gaagtttaat gctgacgaat ttgaagacat ggtggccaag aagtgcctca      660

tccctgatgg ttgtggagtc aagtacgttc ccagtcatgg ccccttggac aagtggcggg      720

ttctgcactc atgaaggttt tggcagtact gtctccttgg gccatgctgg tctgacttat      780

gcttactaat aaattctgtt tactggc                                          807


<210> 660
<211> 5038
<212> DNA
<213> Homo sapiens

<400> 660
atttcaaaat cttatgtcaa agtaagcgcg cagaaagggg tccttgctct tctacactga       60

gccctacggc ccccctgtgg ggaaatactc ctgataatca tctcgaaaat tgtttcgacc      120

agcaggggtc actatgaagg ctgacttgag cccaagacac aatggggcac ggtaaccaga      180

ctggtccgta agggttccag gaaggaatgc agtttcaaga gaacagtttg aatctttatt      240

cgaatttgaa ttttggtaca atgaagagag tcagctgcaa cttgacaatc gaaatcttca      300

gaaaagcgac acaaatacgt tcgcctcgag gaatattggg tcttctgcgc ggccgtagag      360

ctccgccaag tgcgcctgcg cggaggagaa gtggcgtcga gtccggccgg gcagtagagg      420

aacttgcggt agtgaccctc gggcctcgcc atgaagagcc gctttagcac cattgacctc      480

cgcgccgtac tcgcggagct gaatgctagc ttgctaggaa tgagagtaaa caatgtttat      540

gatgtggata ataagacata ccttattcgt cttcaaaaac cggactttaa agctacactt      600

ttacttgaat ctggcatacg aattcataca acagaatttg agtggcctaa gaatatgatg      660

ccgtctagtt ttgccatgaa gtgccgaaaa catttgaaga gtcggagatt agtcagtgca      720

aaacagcttg gtgtggatag aattgtagat tttcaatttg gaagtgatga agctgcttac      780

catttaatca ttgagctcta tgataggggg aacattgttc ttacagatta tgagtacgta      840

attttaaata ttctaaggtt tcgaactgat gaggcagatg atgttaaatt tgctgttcgt      900

gaacgctatc cacttgatca tgctagagct gctgaacctt tgcttacttt ggaaaggttg      960

actgaaatag tagccagcgc acctaagggt gaactactga agagggtgct taacccatta     1020

cttccctatg gaccagctct cattgaacac tgtcttttag aaaatggatt ctcgggtaat     1080

gtcaaagtgg atgaaaaact tgaaactaaa gatattgaaa aagtacttgt ttctctgcag     1140

aaagcagaag actatatgaa aacaacatcc aacttcagtg ggaagggata tatcattcag     1200

aaaagagaaa taaaaccaag cttggaagca gataaaccag ttgaagacat actgacgtat     1260

gaggaatttc atcctttctt gttttctcaa cattcacaat gtccatatat agaatttgaa     1320

tcatttgaca aggcggtgga tgaattttat tccaagatag aaggccagaa aattgactta     1380

aaagctttac aacaggaaaa gcaagcattg aagaaattag ataatgttcg aaaggatcac     1440

gaaaacagat tggaagctct tcagcaggct caggaaatag acaaactgaa aggagagctc     1500

atagaaatga acctacaaat agttgacaga gccattcagg tagttcgaag tgctttagct     1560

aaccagatag attggacaga aattgggtta attgtgaaag aagcccaggc tcaaggagac     1620

cctgttgcaa gtgcaatcaa agaattaaaa ctacaaacaa accatgttac aatgctgcta     1680

agaaatccat acttgttatc agaggaggaa gatgatgatg ttgatggtga cgtcaatgtt     1740

gagaaaaatg aaactgaacc accaaaagga aaaaagaaaa aacaaaagaa taaacagctg     1800

cagaagcctc agaaaaataa gcccttactt gtagatgttg atctcagctt gtcagcatat     1860

gccaatgcca aaaagtatta tgatcacaag agatatgctg ctaagaaaac acaaaagact     1920

gttgaagctg ctgagaaggc attcaagtca gcagaaaaga aaacaaagca aacattaaaa     1980

gaagttcaga ctgttacctc tattcaaaaa gcaagaaaag tatattggtt tgagaaattt     2040

ctgtggttca ttagctcaga gaactatcta attataggtg gacgagatca gcaacagaat     2100

gaaataattg tgaaaagata cttgacacca ggagacattt atgtacatgc tgatcttcat     2160

ggagctacta gctgtgtaat taagaatcca acaggagaac ccatcccccc acggaccttg     2220

actgaagctg gcacaatggc actttgctac agtgctgctt gggatgcacg agttatcact     2280

agtgcttggt gggtgtacca tcatcaggta tctaaaacag caccaactgg agaatatttg     2340

acaacaggaa gcttcatgat aagaggaaaa aagaattttc ttcctccctc atatctaatg     2400

atggggttta gcttcctttt taaggtagat gagtcttgtg tttggagaca tcagggtgaa     2460

cgaaaagtca gagtacagga tgaagacatg gagacactgg caagttgtac aagtgaactc     2520

atatcagaag aaatggaaca attagatgga ggtgacacga gcagtgatga ggataaagaa     2580

gaacatgaaa ctcctgtgga agtagaactc atgactcagg ttgaccaaga ggatatcact     2640

cttcagagtg gcagagatga actaaatgag gagctcattc aggaagaaag ctctgaagac     2700

gaaggagaat atgaagaggt tagaaaagat caggattctg ttggtgaaat gaaggatgaa     2760

ggggaagaga cattaaatta tcctgatact accattgact tgtctcacct tcaaccccaa     2820

aggtccatcc agaaattggc ttcaaaagag gaatcttcta attctagtga cagtaaatca     2880

cagagccgga gacatttgtc agccaaggaa agaagggaaa tgaaaaagaa aaaacttcca     2940

agtgactcag gagatttaga agcgttagag ggaaaggata aagaaaaaga aagtactgta     3000

cacattgaaa ctcatcagaa cacaagcaaa aatgttgcgg ctgtgcagcc aatgaaacga     3060

ggacaaaaga gtaaaatgaa aaaaatgaaa gaaaaataca aagaccagga tgaagaagac     3120

cgtgaactta tcatgaagtt gctggggtct gcaggttcaa acaaagaaga aaaagggaag     3180

aaggggaaga aaggaaaaac aaaggacgaa cctgtgaaga aacagcccca gaaacctaga     3240

ggtggacaga gggtctctga caacattaag aaagaaactc cgttccttga ggttataact     3300

catgagttac aagactttgc tgtagatgat ccacatgatg acaaggaaga gcaagatctg     3360

gatcaacagg gaaatgagga aaacctattt gattctttga caggccagcc acatcctgaa     3420

gatgtactac tgtttgccat tccaatatgt gccccttaca ccaccatgac aaactacaaa     3480

tataaagtga aacttactcc tggagtgcag aaaaagggaa aagctgcaaa aacagccttg     3540

aatagtttca tgcattccaa agaagcaaca gcaagagaaa aagacttatt ccgcagcgta     3600

aaggacacag atttatcaag aaacattcct ggcaaagtga aagtgtctgc acccaatctt     3660

ctgaatgtaa aaaggaaata gctgaaatga aattctaaaa tatttgagaa gagccaattt     3720

tatagccttt tggaagttca aagatgaaag caccatgtat caggatttcc gcattataaa     3780

aatgaactaa acattgcctt gctatattca ccaaaaggac ttacttcttg ttttttccca     3840

gttttatata gaggaaacac tgtctatgat aggatttcca aaagtatttg tggacagtta     3900

aatgctaatt aatatacatc tgtagttatt ctacattttc ttgaaatttg ggaggttaat     3960

accaagtatt catttcatga tgtaaagaaa ctgaacagtg aagtggcttg attgcttaaa     4020

ctattgactt ggtaagtcta ctgtatataa catctaatat atatattaca ggccaaatga     4080

actaaacatt gccttgctat attcaccaaa aggacttaat tcttgttttt ttcccagttt     4140

tatatagagg aaacactatg ataggatttc ctaaagtatt tgtggacagt taaatgctaa     4200

ttatatacat ctgtagttat tctacatttt cttgaaattt gggaggttaa taccaagtat     4260

tcatttcatg atgtaaagaa actgaacagt gaagtggctt gattgcttaa actattgact     4320

tggtaagtct actgtatata acatctaata tatatatatt ataggccagc tacaaggggt     4380

ttaaatattt aggattgtgt cttgaaaact aagtattgga gtggattttc ttctgctttc     4440

attgatactt gtcagaaaaa aatattagac caaaatgtaa aatataagta ataattctca     4500

tgactcagct taatcatttc tattcatttg tagaccttca ggtttgatct taattttttc     4560

cttgtaatct gattcagttc tgtaccattt taatttccac ctttagtaat taattaccaa     4620

tatagcacgt tagagtatct taacctataa taccagaagc gcattttagg cttaccacta     4680

aagactctaa cccacttttc ctctgtctct taacagaatg gaaaatgatg tcatcattat     4740

ttccattcct tcatgagcta taaaacctat taattaaaaa aaaacttttt aattgactgg     4800

acagcacctg cctgtattca gcatgaccac ttgctccagc ccctacactg aagcattaag     4860

gtcaaagtac tgaacagttg ttggtccctc cacactttgt ttttccagct tcgtcataat     4920

gtgaatatta atgtttaaaa aaaaaaacct ttattatatt gtatttacaa cactaggtta     4980

cataactata gactactctt gccattaaaa aaaaaaaaat ctataatgtt ttcaaaaa       5038


<210> 661
<211> 1566
<212> DNA
<213> Homo sapiens

<400> 661
cagtagctcg cgcggtgcct gtcggtagtc gcgtgcgggg cggcggggcg gcggggcggc       60

cggcggcggc catgggagat atcccagccg tgggcctcag ctcctggaag gcttctccag      120

ggaaagtgac cgaggcagtg aaagaggcca ttgacgcagg gtaccggcac ttcgactgtg      180

cttactttta ccacaatgag agggaggttg gagcagggat ccgttgcaag atcaaggaag      240

gcgctgtaag acgggaggat ctgttcattg ccactaagct gtggtgcacc tgccataaga      300

agtccttggt ggaaacagca tgcagaaaga gtctcaaggc cttgaagctg aactatttgg      360

acctctacct catacactgg cccatgggtt tcaagcctcc tcatccagaa tggatcatga      420

gctgcagtga actttccttc tgcctctcac atcctcgagt gcaggacttg cctctggacg      480

agagcaacat ggttattccc agtgacacgg acttcctgga cacgtgggag gccatggagg      540

acctggtgat caccgggctg gtgaagaaca tcggggtgtc aaacttcaac catgaacagc      600

ttgagaggct tttgaataag cctgggttga ggttcaagcc actaaccaac cagattgagt      660

gccacccata tcttactcag aagaatctga tcagtttttg ccaatccaga gatgtgtccg      720

tgactgctta ccgtcctctt ggtggctcgt gtgagggggt tgacctgata gacaaccctg      780

tgatcaagag gattgcaaag gagcacggca agtctcctgc tcagattttg atccgatttc      840

aaatccagag gaatgtgata gtgatccccg gatctatcac cccaagtcac attaaagaga      900

atatccaggt gtttgatttt gaattaacac agcacgatat ggataacatc ctcagcctaa      960

acaggaatct ccgactggcc atgttcccca taactaaaaa tcacaaagac tatcctttcc     1020

acatagaata ctgaggacgc ttccccttcc ttgtttctgc tcagcccaga tgcacagaca     1080

ctattggcaa tgttgaccct cctctgtcat cacagcgcca gggcagctgt gcctgggaca     1140

ggagccacac agtcagaggg ggatgtaaga gccaccttct ctgacaaatc tggagaattg     1200

agtgtgttct aagtgaaggc aatggggttt ctccaagaca gcctgtgtgg cctctactct     1260

gaacaaatac actgatgagt catcagtgaa atttgccttc acattttaag aaaactttat     1320

cttatggagt tatttaagcc atctacagag ctgaggaaac agtgtaatgt gtctctgccc     1380

cattgcgcag ctccacccat tgtgccccag gccagcccgc gtcacctaca cttccttctg     1440

tgccctgcca gtgaccccca ggttattcta aagcagagtc cttcccttcc cccagtgaga     1500

aggaaaatgg gataagtctg ggacactgtt tcagttcaat aaagaggctt ttttcttcct     1560

taaaaa                                                                1566


<210> 662
<211> 2314
<212> DNA
<213> Homo sapiens

<400> 662
cctcgccgac ggcccaaggc gttcaggcac gcgctttcgg tgctcggagc ggaagcagcg       60

gcgagaggct cggaggcgcg ggggcggccg agcggcgggc gacgggggcg ggcgacgggg      120

gcgggcgacg cgggccgcgg cacgggcgga gccggggcca tggagccgcc gctgccgggc      180

taggcaggtc gtgccccgcc gggccggcgg cgatgtcggg ctaccagcgc cgcccgggcg      240

ccaccccgct gtcccgagcc cggagcctcg ccattcccga cgctccagcg ttctatgagc      300

gccggtcttg tctcccccag ctaaattgtg agcgccccca tggcagggac ctggactccc      360

ccttcttcgg cattcggccg gcctttatgt gctatgtgcc cagcccggtg ctggcttccg      420

tgggagacac agatgacaga tttgaagatc tggaagaggc aaatccattc tcttttagag      480

agtttctgaa gaccaagaac ctcggcctct cgaaagagga tccggccagc agaatttatg      540

caaaggaagc ctcgaggcat tccctgggac ttgaccacaa ctccccaccc tcccaaaccg      600

gcgggtatgg cctggagtat cagcagccat ttttcgagga tccgacaggg gctggtgacc      660

tcctggatga ggaggaggat gaggacaccg gatggagtgg ggcctacctg ccgtccgcca      720

tcgagcagac tcaccccgag agggtccctg ccggcacgtc gccctgcagc acataccttt      780

cctttttctc caccccgtcg gagctggcag ggcctgagtc tctgccctcg tgggcgttga      840

gtgacactga ttctcgcgtg tctccggcct ctccggcagg gagtcctagc gcagactttg      900

cggttcatgg agagtctctg ggagacaggc acctgcggac gctgcagata agttacgacg      960

cactgaaaga tgaaaattct aagctgagaa gaaagctgaa tgaggttcag agcttctctg     1020

aagctcaaac agaaatggtg aggacgcttg agcggaagtt agaagcaaaa atgatcaagg     1080

aggaaagcga ctaccacgac ctggagtcgg tggttcagca ggtggagcag aacctggagc     1140

tgatgaccaa acgggctgta aaggcagaaa accacgtcgt gaaactaaaa caggaaatca     1200

gtttgctcca ggcgcaggtc tccaacttcc agcgagagaa tgaagccctg cggtgcggcc     1260

agggtgccag cctgaccgtg gtgaagcaga acgccgacgt ggccctgcag aacctccggg     1320

tggtcatgaa cagtgcacag gcttccatca agcaactggt ttccggagct gagacactga     1380

atcttgttgc cgaaatcctt aaatctatag acagaatttc tgaagttaaa gacgaggagg     1440

aagactcttg aggacccctg ggtgttctca gcatgaagct ccgtgtatac cctgaggtca     1500

ccaccgctcg atctaaatgt gcagttgtgt ccttaaatat gcagtcttca cccagagtaa     1560

agtgttgatc gcaagagtcc agtgtcgtgc cctcagccag ttcttggcca ccacaatggg     1620

agcagccctg gccgagttgt ctctgtggtt tctatgcagc ccttcttggc gaaattcctg     1680

cgatcttata gattctaatg agctcttgga agacattgtc ataaaagcca gtgattttaa     1740

gaaaaagagt ggttctggaa tcaatgtttt ccagtcccat cccagaacat cagttgtaag     1800

ataagtacaa ttggttgtcc ttgatttcat aagtagaaca aacactaaat gtgcctctga     1860

gatggccacc ccgggcaggg acctgtgcct tccgccgatg ctcagggctc cctctggctc     1920

ccgggtcact cttgtggccc cagtgggtgg tccctgcagt catggcctga gtgcgcaggg     1980

gccaccgcgt ggctgctgct gtcctcctcc gggacccacg gggaccaagg tcacacgttc     2040

cgtgctgtga agctgtccag atgtgcctct ttggctgggg gttctggtgg acgtttcaag     2100

tggcattttg tacaatgcag gttagaattc aggaatttca agtatgtgcc cgggtctgtc     2160

aggtcccagt tgcctttctg acggcccccc tcagagggac ggcgatgagc actaaatgct     2220

tttttgacta ttttcctata gatttttttt aaaacttttt tttcctcctg ttccaattga     2280

tagctttctt atttaataaa ttctgtagtt cacc                                 2314


<210> 663
<211> 2072
<212> DNA
<213> Homo sapiens

<400> 663
cggggctcga ctctaggagt tgggctgagg atttccaccc gatcctcgaa cctccggccc       60

atctcatgga cgcccctccc ccttcaaaca ccctccccca catttattcc cgcgtctgtt      120

ttaaagatgg gtaaactgag gcacagggag ccgggccggg gagcactgac agaaccagaa      180

gcaggttctg cctcccgtcc cctcggaggg ccgacttgcc ccttctgggt ttcgtcgggg      240

gtctcagata cgaggaggcc cagctggaag ccacctgagg gtgtcccccg ctaagatgcg      300

caaatgggaa aagcgaggcc ggggttgggg aaagaacttg cccgagccgc agagcgcgtc      360

agccggggag gtcggggcgg gggcgacccg cgcgaccgag gatcgggtat ctgggcccgg      420

cgcggagcct gcagggcggg gccgcggcgc gtgctgatga cgcagtcggc gcggcggccc      480

tagcgacgcg gttactaggg agcggcgagc cgagacggct acatggacgc cactatcgcc      540

ccgcaccgta tcccccccga gatgccccag tacggggagg agaaccacat cttcgagttg      600

atgcagaaca tgctggagca actcctgatc caccagcccg aagatcccat ccccttcatg      660

atccagcact tgcatagaga caacgacaat gtgcccagga ttgtaatatt aggtccaccc      720

gcctcaggga aaacaacaat agcaatgtgg ctctgcaaac atctgaacag cagtctcctc      780

accctggaga acctgatctt aaatgagttt tcctatacgg ccaccgaagc cagaaggctt      840

tatctgcaaa ggaagacagt tcccagcgcg ctgctcgtcc agctgattca ggaacgcctg      900

gctgaagagg attgcatcaa gcagggctgg attctggatg gcatccctga gacgcgtgag      960

caggctctga ggatccagac cctggggatc acacccagac acgtcattgt gctgagtgct     1020

ccagacacgg tcctgatcga gagaaacttg gggaagagaa tcgaccctca aactggagag     1080

atttatcaca ccacctttga ctggccaccc gaatctgaaa tccagaaccg tctcatggtg     1140

ccagaggaca tctcagagct ggagacggct cagaaactgc tggagtatca taggaacatc     1200

gtcagggtca ttccctccta ccccaaaatc ctcaaagtca tcagtgctga ccagccatgt     1260

gtggacgtct tctaccaggc tctgacctat gtccaaagca accatcgtac taatgccccg     1320

ttcaccccga gggtgctgct gctcgggcct gtgggcagtg ggaaaagtct gcaggccgcc     1380

ctcctggccc agaaatacag gcttgtcaat gtctgctgtg ggcaactgct gaaagaggct     1440

gtggcagata ggaccacgtt tggcgagctc atccagccct tctttgaaaa ggagatggca     1500

gttcctgaca gcctcctcat gaaggtgctg agccagcgcc tggaccagca ggactgcatc     1560

cagaaaggct gggtgctaca cggcgtcccg cgggacctcg accaggcaca cctgctgaac     1620

cgcctgggct acaatcccaa cagggtgttt ttcctgaatg tgccatttga ttccatcatg     1680

gagcggctga ctctgagaag aattgatcca gtcactgggg aaaggtacca cctcatgtac     1740

aagccacctc ccaccatgga gatccaggct cgcctcctgc agaacccaaa ggatgctgaa     1800

gagcaggtca agctgaaaat ggacctgttc tacaggaact cagctgactt ggagcagttg     1860

tatgggtcgg ccatcaccct caatggggac caggacccat acacagtctt cgaatacatc     1920

gagagtggga tcattaatcc cctgcccaag aaaatcccct gatgggttca gagccaggag     1980

cgctgcccca gggaaagagt taatcccctg cccccagccc cccagcctcg gcacagctcc     2040

cctaaaaagc caataaagcc tgctggatac ag                                   2072


<210> 664
<211> 1935
<212> DNA
<213> Homo sapiens

<400> 664
ggtgggaaaa gaggacttat tgttgtcatg gcccatgaga tgattggaac tcaaattgtt       60

actgagaggt tggtggctct gctggaaagt ggaacggaaa aagtgctgct aattgatagc      120

cggccatttg tggaatacaa tacatcccac attttggaag ccattaatat caactgctcc      180

aagcttatga agcgaaggtt gcaacaggac aaagtgttaa ttacagagct catccagcat      240

tcagcgaaac ataaggttga cattgattgc agtcagaagg ttgtagttta cgatcaaagc      300

tcccaagatg ttgcctctct ctcttcagac tgttttctca ctgtacttct gggtaaactg      360

gagaagagct tcaactctgt tcacctgctt gcaggagctg atgcagcaga atgggattgg      420

ttatgtgtta aatgccagca atacctgtcc aaagcctgac tttatccccg agtctcattt      480

cctgcgtgtg cctgtgaatg acagcttttg tgagaaaatt ttgccgtggt tggacaaatc      540

agtagatttc attgagaaag caaaagcctc caatggatgt gttctagtgc actgtttagc      600

tgggatctcc cgctccgcca ccatcgctat cgcctacatc atgaagagga tggacatgtc      660

tttagatgaa gcttacagat ttgtgaaaga aaaaagacct actatatctc caaacttcaa      720

ttttctgggc caactcctgg actatgagaa gaagattaag aaccagactg gagcatcagg      780

gccaaagagc aaactcaagc tgctgcacct ggagaagcca aatgaacctg tccctgctgt      840

ctcagagggt ggacagaaaa gcgagacgcc cctcagtcca ccctgtgccg actctgctac      900

ctcagaggca gcaggacaaa ggcccgtgca tcccgccagc gtgcccagcg tgcccagcgt      960

gcagccgtcg ctgttagagg acagcccgct ggtacaggcg ctcagtgggc tgcacctgtc     1020

cgcagacagg ctggaagaca gcaataagct caagcgttcc ttctctctgg atatcaaatc     1080

agtttcatat tcagccagca tggcagcatc cttacatggc ttctcctcat cagaagatgc     1140

tttggaatac tacaaacctt ccactactct ggatgggacc aacaagctat gccagttctc     1200

ccctgttcag gaactatcgg agcagactcc cgaaaccagt cctgataagg aggaagccag     1260

catccccaag aagctgcaga ccgccaggcc ttcagacagc cagagcaagc gattgcattc     1320

ggtcagaacc agcagcagtg gcaccgccca gaggtccctt ttatctccac tgcatcgaag     1380

tgggagcgtg gaggacaatt accacaccag cttccttttc ggcctttcca ccagccagca     1440

gcacctcacg aagtctgctg gcctgggcct taagggctgg cactcggata tcttggcccc     1500

ccagacctct accccttccc tgaccagcag ctggtatttt gccacagagt cctcacactt     1560

ctactctgcc tcagccatct acggaggcag tgccagttac tctgcctaca gctgcagcca     1620

gctgcccact tgcggagacc aagtctattc tgtgcgcagg cggcagaagc caagtgacag     1680

agctgactcg cggcggagct ggcatgaaga gagccccttt gaaaagcagt ttaaacgcag     1740

aagctgccaa atggaatttg gagagagcat catgtcagag aacaggtcac gggaagagct     1800

ggggaaagtg ggcagtcagt ctagcttttc gggcagcatg gaaatcattg aggtctcctg     1860

agaagaaaga cacttgtgac ttctatagac aatttttttt tcttgttcac aaaaaaattc     1920

cctgtaaatc tgaaa                                                      1935


<210> 665
<211> 1724
<212> DNA
<213> Homo sapiens

<400> 665
gagaagtgtg ggctacccgg ccactgccct ggagctgtgg tgactgctgc gtttttctcc       60

catgcacttg cacgtccagg actcctggga gaacttgggc cacactcctt ccttgccctc      120

ttgagctcat tcgtcaccct gttgggtgag cacagcccta gctcaggcca ctgggcaagc      180

cacaccatcc aaagaggagg tcctctgccc caggaccccc acaccacccc agctccctgt      240

ttcgctgagg cctggagccc ccatggcctc actgagccga gccctacgtg tggctgctgc      300

ccaccctcgc cagagcccta cccggggcat ggggccatgc aacctgtcca gcgcagctgg      360

ccccacagcc gagaagagtg tgccatatca gcggaccctg aaggagggac agggcacctc      420

ggtggtggcc caaggcccaa gccggcccct gcccagcacg gccaacgtgg tggtcattgg      480

tggaggcagc ttgggctgcc agaccctgta ccacctggcc aagctgggca tgagtggggc      540

ggtgctgctg gagcgggagc ggctgacctc cgggaccacc tggcacacgg caggcctgct      600

gtggcagctg cggcccagtg acgtggaggt ggagcttctg gcccacactc ggcgggtggt      660

gagccgggag ctggaggagg agacgggact acacacgggc tggatccaga atgggggcct      720

cttcatcgcg tccaaccggc agcgcctgga cgagtacaag aggctcatgt cgctgggcaa      780

ggcgtatggt gtggaatccc atgtgctgag cccggcagag accaagactc tgtacccgct      840

gatgaatgtg gacgacctct acgggaccct gtatgtgccg cacgacggta ccatggaccc      900

cgctggcacc tgtaccaccc tcgccagggc agcttctgcc cgaggagcac aggtcattga      960

gaactgccca gtgaccggca ttcgtgtgtg gacggatgat tttggggtgc ggcgggtcgc     1020

gggtgtggag actcagcatg gttccatcca gacaccctgc gtggtcaact gtgcaggagt     1080

gtgggcaagt gctgtgggcc ggatggctgg agtcaaggtc ccgctggtgg ccatgcacca     1140

tgcctatgtc gtcaccgagc gcatcgaggg gattcagagt ttcactttgt tgcccacact     1200

ggagtacagt ggcacagtgt cagctcactg caacctccgc ctcccgggtt caagcaattc     1260

tcgtgcctca gcctcccatg tagctgggat taaatgtgcc cgtcaccaca cccggctgat     1320

ttttttttgt attttagtag agacggagtt tcaccatgtt gccaaggctg gtctcgaact     1380

cctgagctca ggcaatccac ccatctcgga cttccaaagt gctaggatta caggcgtgag     1440

ccaccatgct tagctgatta tgtaaacatt gttaatacct gagcaagtag tgtccaactt     1500

tttgtgtttc ttggagttat taacagtttt tgtcccagct gctcagtttc ttttgtaact     1560

gttatgtgtg tgtgtgtaac attatcttca tgccccaaaa cccatacccg ttatcaatca     1620

ctccccattt cccaccctgt ccccagactt aggcaatccc aaatctgatt tctgcctcga     1680

tggagtttcc tattctggac gtttagtata aatggaatca catg                      1724


<210> 666
<211> 5314
<212> DNA
<213> Homo sapiens

<400> 666
aagcgtcgga cgcggcccgg cgccgagcca tggagcctga gccagtggag gactgtgtgc       60

agagcactct cgccgccctg tatccaccct ttgaggcaac agcccccacc ctgttgggcc      120

aggtgttcca ggtggtggag aggacttatc gggaggacgc actgaggtac acgctggact      180

tcctggtacc agccaagcac ctgcttgcca aggtccagca ggaagcctgt gcccaataca      240

gtggattcct cttcttccat gaggggtggc cgctctgcct gcatgaacag gtggtggtgc      300

agctagcagc cctaccctgg caactgctgc gcccaggaga cttctatctg caggtggtgc      360

cctcagctgc ccaagcaccc cgactagcac tcaagtgtct ggcccctggg ggtgggcggg      420

tgcaggaggt tcctgtgccc aatgaggctt gtgcctacct attcacacct gagtggctac      480

aaggcatcaa caaggaccgg ccaacaggtc gcctcagtac ctgcctactg tctgcgccct      540

ctgggattca gcggctgccc tgggctgagc tcatctgtcc acgatttgtg cacaaagagg      600

gcctcatggt tggacatcag ccaagtacac tgcccccaga actgccctct ggacctccag      660

ggcttcccag ccctccactt cctgaggagg cgctgggtac ccggagtcct ggggatgggc      720

acaatgcccc tgtggaagga cctgagggcg agtatgtgga gctgttagag gtgacgctgc      780

ccgtgagggg gagcccaaca gatgctgaag gctccccagg cctctccaga gtccggacgg      840

tacccacccg caagggcgct ggagggaagg gccgccaccg gagacaccgg gcgtggatgc      900

accagaaggg cctggggcct cggggccagg atggagcacg cccacccggc gaggggagca      960

gcaccggagc ctcccctgag tctcccccag gagctgaggc tgtcccagag gcagcagtct     1020

tggaggtgtc tgagccccca gcagaggctg tgggagaagc ctccggatct tgccccctga     1080

ggccagggga gcttagagga ggaggaggag gaggccaggg ggctgaagga ccacctggta     1140

cccctcggag aacaggcaaa ggaaacagaa gaaagaagcg agctgcaggt cgaggggctc     1200

ttagccgagg aggggacagt gccccactga gccctgggga caaggaagat gccagccacc     1260

aagaagccct tggcaatctg ccctcaccaa gtgagcacaa gcttccagaa tgccacctgg     1320

ttaaggagga atatgaaggc tcagggaagc cagaatctga gccaaaagag ctcaaaacag     1380

caggcgagaa agagcctcag ctctctgaag cctgtgggcc tacagaagag ggggccggag     1440

agagagagct ggaggggcca ggcctgctgt gtatggcagg acacacaggc ccagaaggcc     1500

ccctgtctga cactccaaca cctccgctgg agactgtgca ggaaggaaaa ggggacaaca     1560

ttccagaaga ggcccttgca gtctccgtct ctgatcaccc tgatgtagct tgggacttga     1620

tggcatctgg attcctcatc ctgacgggag gggtggacca gagtgggcga gctctgctga     1680

ccattacccc accgtgccct cctgaggagc ccccaccctc ccgagacacg ctgaacacaa     1740

ctcttcatta cctccactca ctgctcaggc ctgatctaca gacactgggg ctgtccgtcc     1800

tgctggacct tcgtcaggca cctccactgc ctccagcact cattcctgcc ttgagccaac     1860

ttcaggactc aggagatcct ccccttgttc agcggctgct gattctcatt catgatgacc     1920

ttccaactga actctgtgga tttcagggtg ctgaggtgct gtcagagaat gatctgaaaa     1980

gagtggccaa gccagaggag ctgcagtggg agttaggagg tcacagggac ccctctccca     2040

gtcactgggt agagatacac caggaagtgg taaggctatg tcgcctgtgc caaggtgtgc     2100

tgggctcggt acggcaggcc attgaggagc tggagggagc agcagagcca gaggaagagg     2160

aggcagtggg aatgcccaag ccactgcaga aggtgctggc agatccccgg ctgacggcac     2220

tgcagaggga tgggggggcc atcctgatga ggctgcgctc cactcccagc agcaagctgg     2280

agggccaagg cccagctaca ctgtatcagg aagtggacga ggccattcac cagcttgtgc     2340

gcctctccaa cctgcacgtg cagcagcaag agcagcggca gtgcctgcgg cgactccagc     2400

aggtgttgca gtggctctcg ggcccagggg aggagcagct ggcaagcttt gctatgcctg     2460

gggacacctt gtctgccctg caggagacag agctgcgatt ccgtgctttc agcgctgagg     2520

tccaggagcg cctggcccag gcacgggagg ccctggctct ggaggagaat gccacctccc     2580

agaaggtgct ggatatcttt gaacagcggc tggagcaggt tgagagtggc ctccatcggg     2640

ccctgcggct acagcgcttc ttccagcagg cacatgaatg ggtggatgag ggctttgctc     2700

ggctggcagg agctgggccg ggtcgggagg ctgtgctggc tgcactggcc ctgcggcggg     2760

ccccagagcc cagtgccggc accttccagg agatgcgggc cctggccctg gacctgggca     2820

gcccagcagc cctgcgagaa tggggccgct gccaggcccg ctgccaagag ctagagagga     2880

ggatccagca acacgtggga gaggaggcga gcccacgggg ctaccgacga cggcgggcag     2940

acggtgccag cagtggaggg gcccagtggg ggccccgcag cccctcgccc agcctcagct     3000

ccttgctgct ccccagcagc cctgggccac ggccagcccc atcccattgc tccctggccc     3060

catgtggaga ggactatgag gaagagggcc ctgagctggc tccagaagca gagggcaggc     3120

ccccaagagc tgtgctgatc cgaggcctgg aggtcaccag cactgaggtg gtagacagga     3180

cgtgctcacc acgggaacac gtgctgctgg gccgggctag ggggccagac ggaccctggg     3240

gagtaggcac cccccggatg gagcgcaagc gaagcatcag tgcccagcag cggctggtgt     3300

ctgagctgat tgcctgtgaa caagattacg tggccacctt gagtgagcca gtgccacccc     3360

ctgggcctga gctgacgcct gaacttcggg gcacctgggc tgctgccctg agtgcccggg     3420

aaaggcttcg cagcttccac cggacacact ttctgcggga gcttcagggc tgcgccaccc     3480

accccctacg cattggggcc tgcttccttc gccacgggga ccagttcagc ctttatgcac     3540

agtacgtgaa gcaccgacac aaactggaga atggtctggc tgcgctcagt cccttaagca     3600

agggctccat ggaggctggc ccttacctgc cccgagccct gcagcagcct ctggaacagc     3660

tgactcggta tgggcggctc ctggaggagc tcctgaggga agctgggcct gagctcagtt     3720

ctgagtgccg ggcccttggg gctgctgtac agctgctccg ggaacaagag gcccgtggca     3780

gagacctgct ggccgtggag gcggtgcgtg gctgtgagat agatctgaag gagcagggac     3840

agctcttgca tcgagacccc ttcactgtca tctgtggccg aaagaagtgc cttcgccatg     3900

tctttctctt cgagcatctc ctcctgttca gcaagctcaa gggccctgaa ggggggtcag     3960

agatgtttgt ttacaagcag gcctttaaga ctgctgatat ggggctgaca gaaaacatcg     4020

gggacagcgg actctgcttt gagttgtggt ttcggcggcg gcgtgcacga gaggcataca     4080

ctctgcaggc aacctcacca gagatcaaac tcaagtggac aagttctatt gcccagctgc     4140

tgtggagaca ggcagcccac aacaaggagc tccgagtgca gcagatggtg tccatgggca     4200

ttgggaataa acccttcctg gacatcaaag cccttgggga gcggacgctg agtgccctgc     4260

tcactggaag agccccagaa acacttgact cttctggaga tgtgtcccca ggaccaagaa     4320

acagccccag cctgcaaccc ccccaccctg ggagcagcac tcccaccctg gccagtcgag     4380

ggatcttagg gctatcccga cagagtcatg ctcgagccct gagtgacccc accacgcctc     4440

tgtgacctgg agaagatcca gaacttgcgt gcagcttctc ctctcagcac actttgggct     4500

gggatggcag tggggcataa tggagccctg ggcgatcgct gaatttcttc cctctgcttc     4560

ctggacacag aggaggtcta acgaccagag tattgccctg ccaccactat ctctagtctc     4620

cctagcttgg tgccttctcc tgcaggagtc agagcagcca cattgcttgc cttcataccc     4680

tggaggtggg gaagttatcc ctcttccggt gctttcccat cctgggccac tgtatccagg     4740

acatcactcc catgccagcc ctccctggca gcccatgttc tcctcttttc tcaccccctg     4800

actttccctg agaagaatca tctctgccag gtcaactgga gtccctggtg actccattct     4860

gaggtgtcac aagcaatgaa gctatgcaaa caataggagg gtgtgacagg ggaaccgtag     4920

actttatata tgtaattact gttattataa tactattgtt atattaaatg tatttactca     4980

cactttgcct ctaaggagct agagtagtcc tctggattaa ggtgataaat aacttgagca     5040

ctttccctca accagccctt aactagaaca cagaaaataa aaccaagact ggaaggtccc     5100

ctctacccct cccaggccca gagctagctg actgtgtatg agcctgggag aatgtgtctc     5160

ctccacagtg gctcccagag gttccacaca ctctctgaag ctccttctcc cacactgcac     5220

ctactccttg aggctgaact ggtcacagac aaactgggat ccagcacagt ccagcagttc     5280

tcaaaatgag gtcctcaggc cacagtgcgt gaga                                 5314


<210> 667
<211> 5919
<212> DNA
<213> Homo sapiens

<400> 667
gagccgccac cgcggccgga gctgtccctt agccagaccc ggcgagacac gagcggcggg       60

agggaggcgg tggcgcgccc ggccccgccc gcccgaccaa gcgtcggacg cggcccggcg      120

ccgagccatg gagcctgagc cagtggagga ctgtgtgcag agcactctcg ccgccctgta      180

tccacccttt gaggcaacag cccccaccct gttgggccag gtgttccagg tggtggagag      240

gacttatcgg gaggacgcac tgaggtacac gctggacttc ctggtaccag ccaagcacct      300

gcttgccaag gtccagcagg aagcctgtgc ccaatacagt ggattcctct tcttccatga      360

ggggtggccg ctctgcctgc atgaacaggt ggtggtgcag ctagcagccc taccctggca      420

actgctgcgc ccaggagact tctatctgca ggtggtgccc tcagctgccc aagcaccccg      480

actagcactc aagtgtctgg cccctggggg tgggcgggtg caggaggttc ctgtgcccaa      540

tgaggcttgt gcctacctat tcacacctga gtggctacaa ggcatcaaca aggaccggcc      600

aacaggtcgc ctcagtacct gcctactgtc tgcgccctct gggattcagc ggctgccctg      660

ggctgagctc atctgtccac gatttgtgca caaagagggc ctcatggttg gacatcagcc      720

aagtacactg cccccagaac tgccctctgg acctccaggg cttcccagcc ctccacttcc      780

tgaggaggcg ctgggtaccc ggagtcctgg ggatgggcac aatgcccctg tggaaggacc      840

tgagggcgag tatgtggagc tgttagaggt gacgctgccc gtgaggggga gcccaacaga      900

tgctgaaggc tccccaggcc tctccagagt ccggacggta cccacccgca agggcgctgg      960

agggaagggc cgccaccgga gacaccgggc gtggatgcac cagaagggcc tggggcctcg     1020

gggccaggat ggagcacgcc cacccggcga ggggagcagc accggagcct cccctgagtc     1080

tcccccagga gctgaggctg tcccagaggc agcagtcttg gaggtgtctg agcccccagc     1140

agaggctgtg ggagaagcct ccggatcttg ccccctgagg ccaggggagc ttagaggagg     1200

aggaggagga ggccaggggg ctgaaggacc acctggtacc cctcggagaa caggcaaagg     1260

aaacagaaga aagaagcgag ctgcaggtcg aggggctctt agccgaggag gggacagtgc     1320

cccactgagc cctggggaca aggaagatgc cagccaccaa gaagcccttg gcaatctgcc     1380

ctcaccaagt gagcacaagc ttccagaatg ccacctggtt aaggaggaat atgaaggctc     1440

agggaagcca gaatctgagc caaaagagct caaaacagca ggcgagaaag agcctcagct     1500

ctctgaagcc tgtgggccta cagaagaggg ggccggagag agagagctgg aggggccagg     1560

cctgctgtgt atggcaggac acacaggccc agaaggcccc ctgtctgaca ctccaacacc     1620

tccgctggag actgtgcagg aaggaaaagg ggacaacatt ccagaagagg cccttgcagt     1680

ctccgtctct gatcaccctg atgtagcttg ggacttgatg gcatctggat tcctcatcct     1740

gacgggaggg gtggaccaga gtgggcgagc tctgctgacc attaccccac cgtgccctcc     1800

tgaggagccc ccaccctccc gagacacgct gaacacaact cttcattacc tccactcact     1860

gctcaggcct gatctacaga cactggggct gtccgtcctg ctggaccttc gtcaggcacc     1920

tccactgcct ccagcactca ttcctgcctt gagccaactt caggactcag gagatcctcc     1980

ccttgttcag cggctgctga ttctcattca tgatgacctt ccaactgaac tctgtggatt     2040

tcagggtgct gaggtgctgt cagagaatga tctgaaaaga gtggccaagc cagaggagct     2100

gcagtgggag ttaggaggtc acagggaccc ctctcccagt cactgggtag agatacacca     2160

ggaagtggta aggctatgtc gcctgtgcca aggtgtgctg ggctcggtac ggcaggccat     2220

tgaggagctg gagggagcag cagagccaga ggaagaggag gcagtgggaa tgcccaagcc     2280

actgcagaag gtgctggcag atccccggct gacggcactg cagagggatg ggggggccat     2340

cctgatgagg ctgcgctcca ctcccagcag caagctggag ggccaaggcc cagctacact     2400

gtatcaggaa gtggacgagg ccattcacca gcttgtgcgc ctctccaacc tgcacgtgca     2460

gcagcaagag cagcggcagt gcctgcggcg actccagcag gtgttgcagt ggctctcggg     2520

cccaggggag gagcagctgg caagctttgc tatgcctggg gacaccttgt ctgccctgca     2580

ggagacagag ctgcgattcc gtgctttcag cgctgaggtc caggagcgcc tggcccaggc     2640

acgggaggcc ctggctctgg aggagaatgc cacctcccag aaggtgctgg atatctttga     2700

acagcggctg gagcaggttg agagtggcct ccatcgggcc ctgcggctac agcgcttctt     2760

ccagcaggca catgaatggg tggatgaggg ctttgctcgg ctggcaggag ctgggccggg     2820

tcgggaggct gtgctggctg cactggccct gcggcgggcc ccagagccca gtgccggcac     2880

cttccaggag atgcgggccc tggccctgga cctgggcagc ccagcagccc tgcgagaatg     2940

gggccgctgc caggcccgct gccaagagct agagaggagg atccagcaac acgtgggaga     3000

ggaggcgagc ccacggggct accgacgacg gcgggcagac ggtgccagca gtggaggggc     3060

ccagtggggg ccccgcagcc cctcgcccag cctcagctcc ttgctgctcc ccagcagccc     3120

tgggccacgg ccagccccat cccattgctc cctggcccca tgtggagagg actatgagga     3180

agagggccct gagctggctc cagaagcaga gggcaggccc ccaagagctg tgctgatccg     3240

aggcctggag gtcaccagca ctgaggtggt agacaggacg tgctcaccac gggaacacgt     3300

gctgctgggc cgggctaggg ggccagacgg accctgggga gtaggcaccc cccggatgga     3360

gcgcaagcga agcatcagtg cccagcagcg gctggtgtct gagctgattg cctgtgaaca     3420

agattacgtg gccaccttga gtgagccagt gccaccccct gggcctgagc tgacgcctga     3480

acttcggggc acctgggctg ctgccctgag tgcccgggaa aggcttcgca gcttccaccg     3540

gacacacttt ctgcgggagc ttcagggctg cgccacccac cccctacgca ttggggcctg     3600

cttccttcgc cacggggacc agttcagcct ttatgcacag tacgtgaagc accgacacaa     3660

actggagaat ggtctggctg cgctcagtcc cttaagcaag ggctccatgg aggctggccc     3720

ttacctgccc cgagccctgc agcagcctct ggaacagctg actcggtatg ggcggctcct     3780

ggaggagctc ctgagggaag ctgggcctga gctcagttct gagtgccggg cccttggggc     3840

tgctgtacag ctgctccggg aacaagaggc ccgtggcaga gacctgctgg ccgtggaggc     3900

ggtgcgtggc tgtgagatag atctgaagga gcagggacag ctcttgcatc gagacccctt     3960

cactgtcatc tgtggccgaa agaagtgcct tcgccatgtc tttctcttcg agcatctcct     4020

cctgttcagc aagctcaagg gccctgaagg ggggtcagag atgtttgttt acaagcaggc     4080

ctttaagact gctgatatgg ggctgacaga aaacatcggg gacagcggac tctgctttga     4140

gttgtggttt cggcggcggc gtgcacgaga ggcatacact ctgcaggcaa cctcaccaga     4200

gatcaaactc aagtggacaa gttctattgc ccagctgctg tggagacagg cagcccacaa     4260

caaggagctc cgagtgcagc agatggtgtc catgggcatt gggaataaac ccttcctgga     4320

catcaaagcc cttggggagc ggacgctgag tgccctgctc actggaagag ccgcccgcac     4380

ccgggcctcc gtggccgtgt catcctttga gcatgccggc ccctcccttc ccggcctttc     4440

gccgggagcc tgctccctgc ctgcccgcgt cgaggaggag gcctgggatc tggacgtcaa     4500

gcaaatttcc ctggccccag aaacacttga ctcttctgga gatgtgtccc caggaccaag     4560

aaacagcccc agcctgcaac ccccccaccc tgggagcagc actcccaccc tggccagtcg     4620

agggatctta gggctatccc gacagagtca tgctcgagcc ctgagtgacc ccaccacgcc     4680

tctgtgacct ggagaagatc cagaacttgc gtgcagcttc tcctctcagc acactttggg     4740

ctgggatggc agtggggcat aatggagccc tgggcgatcg ctgaatttct tccctctgct     4800

tcctggacac agaggaggtc taacgaccag agtattgccc tgccaccact atctctagtc     4860

tccctagctt ggtgccttct cctgcaggag tcagagcagc cacattgctt gccttcatac     4920

cctggaggtg gggaagttat ccctcttccg gtgctttccc atcctgggcc actgtatcca     4980

ggacatcact cccatgccag ccctccctgg cagcccatgt tctcctcttt tctcaccccc     5040

tgactttccc tgagaagaat catctctgcc aggtcaactg gagtccctgg tgactccatt     5100

ctgaggtgtc acaagcaatg aagctatgca aacaatagga gggtgtgaca ggggaaccgt     5160

agactttata tatgtaatta ctgttattat aatactattg ttatattaaa tgtatttact     5220

cacactttgc ctctaaggag ctagagtagt cctctggatt aaggtgataa ataacttgag     5280

cactttccct caaccagccc ttaactagaa cacagaaaat aaaaccaaga ctggaaggtc     5340

ccctctaccc ctcccaggcc cagagctagc tgactgtgta tgagcctggg agaatgtgtc     5400

tcctccacag tggctcccag aggttccaca cactctctga agctccttct cccacactgc     5460

acctactcct tgaggctgaa ctggtcacag acaaactggg atccagcaca gtccagcagt     5520

tctcaaaatg aggtcctcag gccacagtgc gtgagaactt gcttggctgt ttgttaaatg     5580

ctaattcttg ggccccatca gagctactgc atcgaaacct gggggtaaaa cccaatattc     5640

tgcatttctt atcaaactct ttgggtgata actaagtgtc tgaagaggtg actatttcct     5700

gacagaagga cccaaagagg gaagcaggac ataggtaggc agacagacac agggccctgt     5760

gcctcaagac acctgtttat tggggacacg actctgcaat agggatgaca ggaatcgtac     5820

caaaaatagc gacgtctaca gggcccctga tggggctaga agggtacagt gccccccacc     5880

ctcacccctt gtacaaaaat aaactctcac gcctatgga                            5919


<210> 668
<211> 3389
<212> DNA
<213> Homo sapiens

<400> 668
cttctcttgt gtaatcagct gcctatttgg aaattgggca gggtttgcga ctggatgcta       60

atgtcactga ctagttttca gcctaccatc cagaagtaac atgttcccag ctttggaaac      120

gcacctaaag cagactattc ctgatcctta tgaagacttt atgtaccgtc acctccaata      180

ttatggctac tttaaagctc agagaggcag tttaccaaac tctgctacgc atcagcatgt      240

tcggaagaat aaccctcaat gcctgttgaa tggctctctt ggggaaaaag atgatttgat      300

accagacacc ctgcaaaagg agaagcttct atggcctatc agtttatctt cagctgtgca      360

cagacagata gaagccatca acagagactt tcactcttgc ctgggctgga tgcagtggcg      420

cggcctcagc tcactgcaac ctccacctcc cagattcaag gattctcctg cctcagcttt      480

ccgagtagct gggattacag attcacatat gctgagttta ccacatctta ggagcagaca      540

gcttctttat gatgagttgg atgaagtaaa cccacgtctt cgagaacccc aagagctctt      600

ttccattttg tctaccaaga ggccactgca ggctccaaga tggccaattg aatgtgaggt      660

catcaaggaa aacatccatc atattgagtg ggctccacct caaccagaat atttctatca      720

gcctaaagga aatgaaaagg taccagagat tgtaggagag aaaaaaggaa cagttgtcta      780

tcaattagat tcagtgccta tagaaggttc ctattttacc agttccagag tgggaggcaa      840

acgaggaatt gtcaaggaac ttgctgtcac gttgcaagga ccagaagata atactctact      900

gtttgaatca aggtttgaga gtgggaatct gcaaaaagct gtcagagtag acacctatga      960

gtatgaactc accttgcgaa ctgacctcta cactaacaaa cacactcagt ggttttattt     1020

tcgtgttcag aacaccagaa aagatgctac ctatcgcttc accattgtca acttgctaaa     1080

acccaagagt ctttatactg tagggatgaa gccactcttg tactcccaat tggatgccaa     1140

cacccgcaat attggctgga ggagagaagg aaatgaaatc aagtactaca agaacaacac     1200

ggatgatggg cagcagccct tctactgtct cacgtggacc attcagtttc catatgacca     1260

ggacacttgc ttctttgcac acttctaccc atatacatac actgatttgc aatgctacct     1320

cctgtcagtg gcaaacaacc ctatccagtc tcagttctgc aagctccaaa ctttatgcag     1380

gagcctagca ggaaataccg tttacttgct caccatcacc aacccatccc agacccctca     1440

agaggcagct gcaaagaaag ctgtggtctt gagtgccaga gttcaccctg gagaaagtaa     1500

tggctcctgg gttatgaaag gctttttgga cttcatcctt agcaactccc cagatgccca     1560

gctcctcaga gatatttttg tcttcaaggt gcttcccatg ttaaatccag atggtgtgat     1620

tgtggggaat tatcggtgtt ccttggccgg aagggatttg aacaggcatt ataaaaccat     1680

tctgaaggag tctttccctt gtatttggta caccaggaac atgatcaaaa gacttcttga     1740

agaaagagag gttctgttgt attgtgattt ccatggccac agtcgtaaga ataatatctt     1800

cctgtatggc tgtaataaca acaatcgcaa atactggctt catgaacgag tctttccttt     1860

aatgttatgc aaaaatgcac cagataagtt ctcttttcac agttgtaatt ttaaggtcca     1920

aaaatgcaaa gaaggaacag gacgagttgt tatgtggcgg atgggaatcc taaacagcta     1980

caccatggag tctacctttg gcgggtccac cctgggtaat aaaagagaca cccactttac     2040

catcgaagat ctgaagtcct taggttatca tgtctgtgac acccttctgg acttttgtga     2100

tcctgaccaa atgaagttca ctcagtgtct agcagagctt aaggagcttt tacgacagga     2160

aatccacaag aaattccatg aacttggaca agatgtagat ttagaaggaa gttggagtga     2220

catctctttg tctgacattg aatccagcac cagtggctct gacagttctc tctcagatgg     2280

tcttcctgtt cacctagcaa acatagcaga tgagctgact cagaaaaaga agatgtttaa     2340

gaagaaaaaa aagaagtcac ttcagactag gaaacagcga aatgagcagt atcagaaaaa     2400

aaatttgatg cagaagttaa agttaacaga agatacctca gaaaaggcag gatttgcttc     2460

tactctgcaa aagcagccaa cctttttcaa aaactcagag aattccagtt ttttaccaat     2520

gaaaaatgaa aacccaaggt taaatgagac aaatttaaat agaagagaca aagacacccc     2580

cctggaccca tcaatggcca ccctgattct gcctaagaat aaagggagaa tgcagaataa     2640

gaagccaggc tttacagtat catgctctcc aaagagaacc ataaactcca gccaagagcc     2700

agctccaggt atgaagccaa actggcctag gagcagatat cctgccacaa agagaggctg     2760

tgctgccatg gcggcatacc catccttgca catatacaca tacccgtagg tgagcctggg     2820

ctgtgccaca caagcacttc atcgggggtt ttgagattag acacatttta taatggggga     2880

gatgtatgac tgggaactgc atttacttgt ggtatactgt gttgtgcact catgcactga     2940

ccttacactt tgtacttaca ctgtgggcat gtggtcaaga tgcatacctc atgaattcaa     3000

ctattttttc ataaaatgaa attttattat gatgtgtaaa aatgctttat cagaaactga     3060

agtgtgttct catggcacac ttcatggcag cacagatata cctcatttta accaatagat     3120

attctctcta aaattatgtg caaatcaatt tttaaaaatc aaaatctatg ttaaacacat     3180

tttggcagtg tgctataata aaaaaaagtg ttgtgtcaaa gctttctagt gacggtcagt     3240

cctactgctg tatgtcaggt ttgctcacaa tgaggtattc ccacatagaa ataacaatgc     3300

atgtattacc cagaatttaa tgttgcgtac cttatgttca atgaggtttt gtaatttttt     3360

taggctgatg attaaaattc tttctctct                                       3389


<210> 669
<211> 4334
<212> DNA
<213> Homo sapiens

<400> 669
gtcggtgcct gcagggctct ccgtggccgc tcgggagagg tgctcttcgc tcaggctccc       60

ccggagactt gagggggtgc gcgctggcgt gcatggggcc tgttctgtcc ttggtttggg      120

gatgctccta aggggggaga aagggatacc tcgggtgctt ggaggtcgag agacggatac      180

gtaagtgcgc aagggccact gattagggca cgggaagggc tcgctagaat gagctcttaa      240

actggttggg tgtaagcggt tttgggctag tctaaaccaa acaactgaga ataaacgcgg      300

ggttcctgca ggttgagaga gtacctgtct gcaaatgtcc agtagtgatg gattgccttg      360

taggccccag agcaatcggg gaagttagca ttcttgttca agaagctgct ggttcactta      420

gagctataaa agaatgttgt gagtttggat tttcttccaa acgttcagga ttgaggttag      480

ggctggtggt gagggatcat gtaaagaggt ttgagtggct cagccttagg tcccggtgtg      540

gaaagcttat tcttttggtg tcatcacgtg gccgtgggaa ttatttagaa tgtgatctgc      600

cctcatgaga agaaaggagc tctgaagccg ttgcagttct tcctccctat gtggaaaatc      660

gaatttctgg aaacatcctc cgtattggga gattttgcct atgtaaaggc tatccttatt      720

ggctagcggc actaattact ttaaaagtag gatggaagta caagtatctc aagcatcatt      780

gggtttcgag ctcacttctg tggaaaagag tttaagggag tggtctagac tttccaggga      840

agttattgcc tggctgtgtc cctctagtcc taattttata cttaactttc ccccacctcc      900

ttcagcctca tctgtttcaa tggtgcaact cttttcatcc ccttttggtt accagtcacc      960

ttcaggccat tcagaggagg aaagagaggg gaatatgaag tcagccaagc cccaagtgaa     1020

ccacagtcag catggggaaa gccagcgggc cttgagcccc ctgcagtcta ctctgagttc     1080

tgctgcatct ccttcccaag cgtatgagac ctatattgaa aatggactca tatgccttaa     1140

acacaaaatt agaaacatcg agaaaaagaa gctcaaactg gaggattata aggatcgcct     1200

gaaaagtgga gagcatctta atccagacca gttggaagct gtagagaaat atgaagaagt     1260

gctacataat ttggaatttg ccaaggagct tcaaaaaacc ttttctgggt tgagcctaga     1320

tctactaaaa gcgcaaaaga aggcccagag aagggagcac atgctaaaac ttgaggctga     1380

gaagaaaaag cttcgaacta tacttcaagt tcagtatgta ttgcagaact tgacacagga     1440

gcacgtacaa aaagacttca aagggggttt gaatggtgca gtgtatttgc cttcaaaaga     1500

acttgactac ctcattaagt tttcaaaact gacctgccct gaaagaaatg aaagtctgag     1560

tgttgaagac cagatggagc agtcatcctt gtacttttgg gaccttttgg aaggtagtga     1620

gaaagcagtg gtaggaacga catacaaaca cttgaaggat ctactgtcta aattgctgaa     1680

ctcaggctat tttgaaagta tcccagttcc caaaaatgcc aaggaaaagg aagtaccact     1740

ggaggaagaa atgctaatac aatcagagaa aaaaacacaa ttatcgaaga ctgaatctgt     1800

caaagagtca gagtctctaa tggaatttgc ccagccagag atacaaccac aagagtttct     1860

taacagacgc tatatgacag aagtagatta ttcaaacaaa caaggcgaag agcaaccttg     1920

ggaagcagat tatgctagaa aaccaaatct cccaaaacgt tgggatatgc ttactgaacc     1980

agatggtcaa gagaagaaac aggagtcctt taagtcctgg gaggcttctg gtaagcacca     2040

ggaggtatcc aagcctgcag tttccttaga acagaggaaa caagacacct caaaactcag     2100

gtctactctg ccggaagagc agaagaagca ggagatctcc aaatccaagc catctcctag     2160

ccagtggaag caagatacac ctaaatccaa agcagggtat gttcaagagg aacaaaagaa     2220

acaggagaca ccaaagctgt ggccagttca gctgcagaaa gaacaagatc caaagaagca     2280

aactccaaag tcttggacac cttccatgca gagcgaacag aacaccacca agtcatggac     2340

cactcccatg tgtgaagaac aggattcaaa acagccagag actccaaaat cctgggaaaa     2400

caatgttgag agtcaaaaac actctttaac atcacagtca cagatttctc caaagtcctg     2460

gggagtagct acagcaagcc tcataccaaa tgaccagctg ctgcccagga agttgaacac     2520

agaacccaaa gatgtgccta agcctgtgca tcagcctgta ggttcttcct ctacccttcc     2580

gaaggatcca gtattgagga aagaaaaact gcaggatctg atgactcaga ttcaaggaac     2640

ttgtaacttt atgcaagagt ctgttcttga ctttgacaaa ccttcaagtg caattccaac     2700

gtcacaaccg ccttcagcta ctccaggtag ccccgtagca tctaaagaac aaaatctgtc     2760

cagtcaaagt gattttcttc aagagccgtt acaggctact tcttctccag ttacttgtag     2820

ctcaaatgct tgcttggtta ctaccgatca ggcttcttct ggatctgaaa cagagtttat     2880

gacctcagag actcctgagg tatttaacgt taatgcacct ctgcctccac gaaaagaaca     2940

agaaataaaa gaatcccctt attcacctgg ctacaatcaa agttttacca cagcaagtac     3000

acaaacacca ccccagtgcc aactgccatc tatacatgta gaacaaactg tccattctca     3060

agagactgca aattatcatc ctgatggaac tattcaagta agcaatggta gccttgcctt     3120

ttacccagca cagacgaatg tgtttcccag acctactcag ccatttgtca atagccgggg     3180

atctgttaga ggatgtactc gtggtgggag attaataacc aattcctatc ggtcccctgg     3240

tggttataaa ggttttgata cttatagagg actcccttca atttccaatg gaaattatag     3300

ccagctgcag ttccaagcta gagagtattc tggagcacct tattcccaaa gggataattt     3360

ccagcagtgt tataagcgag gagggacatc tggtggtcca cgagcaaatt cgagagcagg     3420

gtggagtgat tcttctcagg tgagcagccc agaaagagac aacgaaacct ttaacagtgg     3480

tgactctgga caaggagact cccgtagcat gacccctgtg gatgtgccag tgacaaatcc     3540

agcagccacc atactgccag tacacgtcta ccctctgcct cagcagatgc gagttgcctt     3600

ctcagcagcc agaacctcta atctggcccc tggaacttta gaccaaccta ttgtgtttga     3660

tcttcttctg aacaacttag gagaaacttt tgatcttcag cttggtagat ttaattgccc     3720

agtgaatggc acttacgttt tcatttttca catgctaaag ctggcagtga atgtgccact     3780

gtatgtcaac ctcatgaaga atgaagaggt cttggtatca gcctatgcca atgatggtgc     3840

tccagaccat gaaactgcta gcaatcatgc aattcttcag ctcttccagg gagaccagat     3900

atggttacgt ctgcacaggg gagcaattta tggaagtagc tggaaatatt ctacgttttc     3960

aggctatctt ctttatcaag attgaaagtc agtacagtat tgacaataaa aggatggtgt     4020

tctaattagt gggattgaag gaaaagtagt ctttgccctc atgactgatt ggtttaggaa     4080

aatgtttttg ttcctagagg gaggaggtcc ttactttttt gttttccttc ctgaggtgaa     4140

aaatcaagct gaatgacaat tagcactaat ctggcacttt ataaattgtg atgtagcctc     4200

gctagtcaag ctgtgaatgt atattgtttg cacttaatcc ttaactgtat taacgttcag     4260

cttactaaac tgactgcctc aagtccaggc aagttacaat gccttgttgt gcctcaataa     4320

aaaagttaca tgca                                                       4334


<210> 670
<211> 2441
<212> DNA
<213> Homo sapiens

<400> 670
ccctcatgac gtcagatcgc ccccgcccgc cgcgcagctt ccccgagcga gaccaaaaca       60

ggtggaatcc gggctggagc cggagctccg gcggcgcggg tggcggcacg tccctccaga      120

cagtaccaca ggcacctgga gtaccggcat cggtcgctgt ggcccccgag tgtccgtcag      180

agcctagggg agcctgccct cccgcgcctc gtcggggccc ggccaggcac cttggccgcc      240

ggcgcacgga cgcgggcacg agcactagat cacggctgct ggacctcggc acgttgacaa      300

gatttctctg gggtaccgcg gaggattact ttgaatttcg gtggtcgcct gtggtctggc      360

atatttagaa cttaagtcta ttatttcggg caccatgact ttgaggcttt tagaagactg      420

gtgcaggggg atggacatga accctcggaa agcgctattg attgccggca tctcccagag      480

ctgcagtgtg gcagaaatcg aggaggctct gcaggctggt ttagctccct tgggggagta      540

cagactgctt ggaaggatgt tcaggaggga tgagaacagg aaagtagcct tagtagggct      600

tactgcggag actagtcacg ccctggtccc taaggagata ccgggaaaag ggggtatctg      660

gagagtgatc tttaagcccc ctgacccaga taatacattt ttaagcagat taaatgaatt      720

tttagcggga gagggcatga cagtgggtga gttgagcaga gctcttggac atgaaaatgg      780

ctccttagac ccagagcagg gcatgatccc ggaaatgtgg gcccctatgt tggcacaggc      840

attagaggct cttcagcctg ccctgcaatg cttgaagtat aaaaagctga gagtgttctc      900

gggcagggag tctccagaac caggagaaga agaatttgga cgctggatgt ttcatactac      960

tcagatgata aaggcgtggc aggtgccaga tgtagagaag agaaggcgat tgctagagag     1020

ccttcgaggc ccagcacttg atgttattcg tgtcctcaag ataaacaatc ctttaattac     1080

tgtcgatgaa tgtctgcagg ctcttgagga ggtatttggg gttacagata atcctaggga     1140

gttgcaggtc aaatatctaa ccacttacca gaaggatgag gaaaagttgt cggcttatgt     1200

actaaggctg gagcctttgt tacagaagct ggtacagaga ggagcaattg agagagatgc     1260

tgtgaatcag gcccgcctag accaagtcat tgctggggca gtccacaaaa caattcgcag     1320

agagcttaat ctgccagagg atggcccagc ccctggtttc ttgcagttat tggtactaat     1380

aaaggattat gaggcagctg aggaggagga ggcccttctc caggcaatat tggaaggtaa     1440

tttcacctga gtctcaggga accacgaagg gatatggcaa tgagtagagc atgaaggtag     1500

aacagtctat atactcttgt gacacataca atccctacct tgtgctgcca agtaactcat     1560

ttttgtgcaa ttctcagtat aagccctttg tcgtttctgt gcctatttaa agtctcctaa     1620

aggtgtaatt gactaggaag gatgtagttc tacactgcca tttacctatt taaattcatc     1680

cttgtgaata tctttgttgt tgttgttgag acagagtctc gctctgtcac ccaggctgga     1740

gtgcagtggc gtgatcttgg ctcactgcat cctccgcctt ccaggtttaa gctattctcc     1800

tgcctcagtt gcccgagtag ctgggactac aggcatgtgc caccacgccc agctaagttt     1860

tgcattatca gtagagacgg ggtttcacca tgttggccag gctagtttcg aactcctgac     1920

ctcaagtgat ccacctgctt cggcctctga aagtgctggg attacaggcg tgagacactg     1980

cgcccagcct catccctgtg aatttcttat tgtacacaag ttctttcact atctgtgtgc     2040

agtgctctga ggggacagac aaggcttggg tgtatatgcc aaccagatct cattgaagta     2100

tcagcttgtt tggtactagg tgcaagtgta gcatgtcaca tgtgaccatg ttggatcatt     2160

gacaattttt aggtatgtac tgacctacat ttatgatgaa gatcctgagc ggaggttaag     2220

atattaagtt attttccata tgaatcagaa ttatattgat tctgtgcaat caaaacaaaa     2280

ggcagaatag aatgctgaga ttggttaagt ttgcaatgac catcttgaac cacagatttc     2340

tgctatgtgt catcaaaaca tctagttctg agtaacattt tcacgattgt tataaaatta     2400

taggtgtgaa cttctaaaat aaaggaatgc taataaaatg a                         2441


<210> 671
<211> 3199
<212> DNA
<213> Homo sapiens

<400> 671
gtgctcgcgc caacccctac gccccagcgc gccttctcca cccacgcacg ggcctcggac       60

gcatttccag ccccggcgtt ggttgtggat gctggacatc caccgcctcc aggcagtttc      120

gccgtcacac cgtcgccatc tgtagccaaa gcaaaacata tcctaactga gactttgcag      180

ctcttgtggc cactctgggc tcaccgggaa catgagtgga agagcccgag tgaaggccag      240

aggcatcgcc cgcagcccca gtgccacaga agtggggcgc atccaagcct cgccattgcc      300

tagatctgtt gatcttagta acaatgaagc atcctctagc aatggcttct tgggaacaag      360

caggatctca accaacgata aatatgggat atcttctggt gatgctggaa gtaccttcat      420

ggaaagaggt gtgaaaaaca aacaggactt tatggatttg agtatctgta ccagagaaaa      480

attggcacat gtgagaaatt gtaaaacagg ttccagtgga atacctgtga aactggttac      540

aaacctcttt aacttagatt ttccccaaga ctggcagcta taccagtacc atgtgacata      600

tattccagat ttagcatcta gaaggctgag aattgcttta ctttatagtc atagtgaact      660

ttccaacaaa gcaaaagcat tcgacggtgc catccttttt ctgtcacaaa agctagaaga      720

aaaggtcaca gagttgtcaa gtgaaactca aagaggtgag actataaaga tgactatcac      780

cctgaagagg gagctgccat caagttctcc cgtgtgcatc caggtcttca atatcatctt      840

cagaaagatc ctcaaaaagt tgtccatgta ccaaattgga cggaacttct ataatccttc      900

agagccaatg gaaattcccc agcacaaatt atccctttgg cctgggtttg ccatttctgt      960

gtcatatttt gaaaggaagc tcctgtttag tgctgatgtg agttacaaag tcctccggaa     1020

tgagacggtt ctggaattca tgactgctct ctgtcaaaga actggcttgt cctgtttcac     1080

ccagacgtgt gagaagcagc taatagggct cattgtcctt acaagataca ataacagaac     1140

ctactccatt gatgacattg actggtcagt gaagcccaca cacacctttc agaagcggga     1200

tggcaccgag atcacctatg tggattacta caagcagcag tatgatatta ctgtatcgga     1260

cctgaatcag cccatgcttg ttagtctgtt aaagaagaag agaaatgaca acagtgaggc     1320

tcagctcgcc cacctgatac ctgagctctg ctttctaaca gggctgactg accaggcaac     1380

atctgatttc cagctgatga aggctgtggc tgaaaagaca cgtctcagtc cttcaggccg     1440

gcagcagcgc ctggccaggc ttgtggacaa catccagagg aataccaatg ctcgctttga     1500

actagagacc tggggactgc attttggaag ccagatatct ctgactggcc ggattgtgcc     1560

ttcagaaaaa atattaatgc aagaccacat atgtcaacct gtgtctgctg ctgactggtc     1620

caaggatatt cgaacttgca agattttaaa tgcacagtct ttgaatacct ggttgatttt     1680

atgtagcgac agaactgaat atgttgccga gagctttctg aactgcttga gaagagttgc     1740

aggttccatg ggatttaatg tggactaccc caaaatcata aaagtacaag aaaatccagc     1800

tgcatttgtt agagctatac agcaatatgt tgatcctgat gttcagctgg taatgtgcat     1860

tctgccttct aatcagaaga cctattatga ttccattaaa aaatatttga gctcagactg     1920

cccagtccca agccaatgtg tgcttgctcg gaccttgaat aaacagggca tgatgatgag     1980

tatcgccacc aagatcgcta tgcagatgac ttgcaagctc ggaggcgagc tgtgggctgt     2040

ggaaatacct ttaaagtccc tgatggtggt cggtattgat gtctgtaaag atgcactcag     2100

caaggacgtg atggttgttg gatgcgtggc cagtgttaac cccagaatca ccaggtggtt     2160

ttcccgctgt atccttcaga gaacaatgac tgatgttgca gattgcttga aagttttcat     2220

gactggagca ctcaacaaat ggtacaagta caatcatgat ttgccagcac ggataattgt     2280

gtaccgtgct ggtgtagggg atggtcagct gaaaacactt attgaatatg aagtcccaca     2340

gctgctgagc agtgtggcag aatccagctc aaataccagc tcaagactgt cggtgattgt     2400

ggtcaggaag aagtgcatgc cacgattctt taccgaaatg aaccgcactg tacagaaccc     2460

cccacttggc actgttgtgg attcagaagc aacacgtaac gaatggtatg acttttatct     2520

gatcagccag gtggcctgcc ggggaactgt tagtcctacc tactataatg tcatctatga     2580

tgacaacggc ttgaagcccg accatatgca gagacttaca ttcaaattgt gccacctgta     2640

ctacaactgg ccgggcatag tcagtgtccc agcaccatgt cagtatgctc acaagctgac     2700

ctttctggtg gcacaaagca ttcataaaga acccagtctg gaattagcca accatctctt     2760

ctacctgtga tggcatgaac tactggcatc actagatgga caatccaaga agaaattggt     2820

atactttgtg caaatctgcc ataagctcaa ggctgtgact ggggaaaaag attgagctta     2880

gttttcatgt ctaggaaaaa aagcaaaaca acttaatctg aaacagtttt aaaaaatgtg     2940

tgttattttg ttttaaagag ttgtatgctt ggggtaaatt ttcattgtca tatgtggaat     3000

ttaaatatac catcatctac aaagaattcc acagagttaa atatcttaag ttaaacactt     3060

aaaataagtg tttgcgtgat attttgatga cagataaaca gagtctaatt cccaccccaa     3120

attttgctga ggttttctta atgttgtaga gcattttgta gagtggttta aatagttgaa     3180

aataaagttc agaacatca                                                  3199


<210> 672
<211> 8628
<212> DNA
<213> Homo sapiens

<400> 672
gtgctgtggc ggcggcggcg gcggtagtgg cggcggcggc ggtgcctggg cggcagcagc       60

agcagtagcg gcagccctga ggacggtgag acggccgcgg cggcggcgac agcgcggaag      120

tcgcgcggga cccagagctt cccccctgtc gctagtgctg aggctttcgc ctttcctacc      180

cagcttcttg ctcacggccc gggctgggct gggcagggca acgcgccccc ggggaggggc      240

ggagctgtag atatggtgta agatacttct tcaagattgg acagctgggg accttcttct      300

gattaacctt aaaccaactt gtagccatag agacacctca caaggttccc atttttgttg      360

ttgttgttgt tgattttctg ctcacacctt tcctgacctt gcaaccatgt atggaagtgc      420

ccgctctgtt gggaaggtgg agccgagcag ccagagccct gggcgttcac ccaggcttcc      480

acgttcccct cgcttgggtc accgtcgaac caacagtacg ggagggagtt cgggaagcag      540

tgttggaggt ggcagtggga aaaccctttc aatggaaaat atacaatctt taaatgctgc      600

ctatgccacc tctggcccta tgtatctaag tgaccatgaa aatgtgggtt cagaaacacc      660

taaaagcacc atgacacttg gccgttctgg gggacgtctg ccttacggtg ttcggatgac      720

tgctatgggt agtagcccca atatagctag cagtggggtt gctagtgaca ccatagcatt      780

tggagagcat cacctccctc ctgtgagtat ggcatccact gtacctcact cccttcgtca      840

ggcgagagat aacacaatca tggatctgca gacacagctg aaggaagtat taagagaaaa      900

tgatctcttg cggaaggatg tggaagtaaa ggagagcaaa ttgagttctt caatgaatag      960

catcaagacc ttctggagcc cagagctgaa gaaggaacga gccctgagaa aagatgaagc     1020

ttccaaaatc accatttgga aggaacagta cagagttgta caggaggaaa accaggtgga     1080

tgctctccga ttgcgtttgg aagagaagga aaccatgttg aataaaaaga caaaacaaat     1140

tcaggatatg gctgaagaga aggggacaca agctggagag atacatgacc tcaaggacat     1200

gttggatgtg aaggagcgga aggttaatgt tcttcagaag aagattgaaa atcttcaaga     1260

gcagcttaga gacaaggaaa agcagatgag cagcttgaaa gaacgggtca aatccttgca     1320

ggctgacacc accaacactg acactgcctt gacaactttg gaggaggccc ttgcagagaa     1380

agagcggaca attgaacgct taaaggagca gagggacaga gatgagcgag agaagcaaga     1440

ggaaattgat aactacaaaa aagatcttaa agacttgaag gaaaaagtca gcctgttgca     1500

aggcgacctt tcagagaaag aggcttcact tttggatctg aaagagcatg cttcttctct     1560

ggcatcctca ggactgaaaa aggactcacg gcttaagaca ctagagattg ctttggagca     1620

gaagaaggag gagtgtctga aaatggaatc acaattgaaa aaggcacatg aggcagcatt     1680

ggaagccaga gccagtccag agatgagtga ccgaatacag cacttggaga gagagatcac     1740

caggtacaaa gatgaatcta gcaaggccca ggcagaagtt gatcgactct tagaaatctt     1800

gaaggaggtg gaaaatgaga agaatgacaa agataagaag atagctgagt tggaaagcct     1860

tttttctagg caagtgaaag accagaataa gaaggtagca aatctgaagc acaaggaaca     1920

ggtggaaaaa aagaagagtg cacaaatgtt agaggaggcg cgacgacggg aggacaatct     1980

caacgacagc tctcagcagc tacaggacag tctccgtaag aaggatgaca ggattgaaga     2040

gctggaagaa gcactaagag aaagtgtaca gataactgca gagcgggaaa tggtgctagc     2100

acaagaggaa tcagccagga ccaatgctga aaaacaggtg gaggagttac tgatggccat     2160

ggagaaggta aagcaggaac tagaatccat gaaagcaaag ctgtcctcca cccagcagtc     2220

tctggcagaa aaggaaactc acttgactaa tcttcgggca gagagaagga aacacttaga     2280

ggaagttctg gagatgaagc aagaagctct tctggctgcc attagtgaaa aagacgccaa     2340

tatagctctc ttggagcttt cgtcctctaa gaagaagacc caagaggaag tggctgccct     2400

gaagcgggag aaggatcgtc tggtacagca gcttaagcag cagacgcaaa atcgaatgaa     2460

gctaatggcc gacaactacg aggatgacca cttcaaatcc tcccattcca atcaaacaaa     2520

tcacaagccc tccccagacc aggatgagga ggagggtata tgggcatagc caatcagagg     2580

cttagttcag ccattttgtt cagaacgatc atccagcccc tcttagaact tgaccaaaat     2640

agaagtaaat taaagttgta cattggacac ctgacaaccc tctgccatga ccgagacccc     2700

ctgatcctcc gtggactcac tccaccagct tcctataact tggacgatga ccaggcggct     2760

tgggagaatg agctgcagaa gatgacccgg gggcagcttc aggatgagtt agagaaaggt     2820

gaacgggaca atgcagaact gcaggagttt gccaacgcca ttcttcagca gatagcagac     2880

cattgtcccg acatcctaga gcaagtggtc aacgccctgg aagagtcctc ttgaccctgc     2940

tttatgggga agcctgaggt agtcaaccca ggagccaaga aaagagaact acgaggaaca     3000

ggtgcccgga accttcttgg caccaaacac tacaaacttc atcccaactt gctcacttga     3060

agaagtgtga ttccagcacc gtttctacat ctgccatctt actctgcctt tctgctttgg     3120

atgtggtctc tacactaacc ttcttgatgt ccagggtaga taaagggtcg aatctctctg     3180

aagaactgcc acctggtcat cagcagtgga gaactgtggg agctggtggc tctgccctga     3240

cagagagcca tggagcagag gagcctctca cctcctgtcc tctgacatga gaatgaaacc     3300

aggaatggac ttggagttca acaggctgag aggatgcctc caatggacca gagagctgag     3360

tgttctaata tcacaatagg tgctttctcc taaaagggca aaaaacaatc tcaaaaagat     3420

tagaaaaaga gaagggggga agggaagaga aaatcgactc ttctttttac tgtctcttct     3480

gcttactttc cacatgagat gctttgtacc ggggagctgt gagcaggcct cacgatggct     3540

tgggagcact cgttctccca aggtctgagt cttcatccag ccctgcctgt ctgtcgcagc     3600

cttcctcact ctgttcctcg gccagttaac aagaagatgg tgtgaggtgt tctccaccag     3660

tctctcctgt ttgagactgt tgacgttatc atactgaggt gttagatcaa atatctctaa     3720

ttgaagaaca tgtgaggttg aaagagcacc agccagggca acatagcgtg accctgtctc     3780

tacaaaaaat taaaaagaga acatacaaag ttgacatatg agaccctgtt gtccccgcct     3840

gcagctttgc cccagtaaca gatgcccgtt gctcttgggc tggtttcccc tgaacacctc     3900

caagaggctg cctgccttgc cagcacccgt gtcctgagct cctgcagccc agtggctgct     3960

gaagttgtga tccctcactc accctgctag ctttgccctt gactcgtctt ctctgaacct     4020

cagcctcgtg cattgcctgg aaccttcttc tagcataaat gaaggttttt cctcctacac     4080

acattccttc ctcggttatt tcattcagag aatatttatg aaatgcctac tgtgtgcaag     4140

tcatccatcc ttgaaaaggc cacttctcag tgagggagag atgtagtgga ttctgtgaga     4200

catacctgct ggagttgaag cagtaaatag catgtccttc ccctccccga tcttaaggtg     4260

tgttttctag aaaagttccc taatggaatt catgagtttg ggggtctcag tcacccgctt     4320

gcctgtagga ttccatttga tgattctgga tttttgctgt ttgttattgc ccttagaggg     4380

gctctgagta tctacttgtg ggtggccatt tcctgacatc tgcatgtacc tcgtggaatt     4440

cagccagctt catgttgcaa atcagaaagc tgaccccaag actgcaaatc aatgaaggta     4500

ttggcattgt taaggacgta gcgtagacaa cagcagtcat aaataattag gcaggaactt     4560

aacccaaatc tagttctttg accacctcta ccaccagaac ccagcagaca ctcacatctc     4620

ctgataagag ttgctggact cgatgttttt gttttgcatt ttctcctctc cttccccact     4680

tactcagaga atttaaagtc tgtagagtca gcacagcccc atcagtccag gaacttccca     4740

ccaccagccc ttgactgtcc cattaactga catggtcaga tttccagctc cccctactcc     4800

ctgctgtgaa acaatccctc tccctgtgag aggaaactgt ggagcgtttc ttatcgaagg     4860

ttaaatggac tctgctcata aacctcttac tgagatgctt cctgatagcc aggctggcca     4920

gagaggggtg caggggttag atagtaagtg gtggtcgttt gtggtcagtt acctcaattc     4980

tgttcattgc agtgcccgta aaccatgtag aaagctccca gcactgaaag gcaggagtgt     5040

tagcatctcg ctttatccac cataacgtaa agaactgcgg tgtgataaca gccttcacgg     5100

ggccacggtg gaaccaagac agcaggcgag gccatgccta aacaagtggt ctggcacggg     5160

cactggccag ctgctctctc caagcaggtg gcccagatcc cacccacgtg gactttctca     5220

tcaggtgcag cgcctgccac tctcagccac tgggtgtgtc actctcctct tcatctcagc     5280

attctccatc acttcccctc cagaaaaacg gatggaagga agccctctgt gacactgctt     5340

ctgagaagaa gcatttccgg gaccgatatc atctgtctgg tctctgtgaa cagcaaggaa     5400

tcttcttgac cgttcttggg cactggaggc tggctaggag ttcagtaata aacgtggcct     5460

tcgtgctgta gggcagagtg gatgcagttt gtagctttca gagtgtctca ttgagtctag     5520

atcattgaac caacacttaa ccaaatgtcc cactcccatc acactaggac ttgtcattcc     5580

atgcccctct cctagtggtc atggtttcat atgggcatac aactgctact gaagttatat     5640

agccttgaaa actcagtgca ggttgccctt aattttcccc aaacccctcc atcggcaagt     5700

ctagttgccc tttagcacct aaagatctgc accccaaacc aatgtcacca taaagagggc     5760

acgaagaaga gtgggtgtga tcccaacggg gttttgtaac tgaagaagcc cagtgtgagc     5820

ttctcatctt ttcatatacc tctaaccccc ggtactcatt gaatcattga tgaggtatct     5880

caattgagat ttgcaaggac tttgatacca tttgaaatgg aaaaattttg aacgggcttt     5940

aacatgttta agaaatatgg atggggccgg ccacagtggc tcacgcctgt aatcccagaa     6000

ctctggaagg ctgaggcagg cggatcacct gagatcagga gttcgaggcc agcctggcca     6060

agatggcaaa aaccccgact ctactaaaaa tacaaaatta gccaggcgtg gtggcgtacg     6120

cctgtaatcc cagctactca ggaggcagga gaatcgcttg agcctgggag gcagaggctg     6180

cggtgagccg agatcgtgtc actgcactcc agcctgggtg acagagactc catttaaaaa     6240

aaaaaaaaaa aaatatatat atatatatat atatatatat atggatggga atcaccaaat     6300

tcatctcagc tctaaccttt taacctttgt ccttgcactt tacaatctaa agatctacct     6360

gtggctctca gacttcctca cacttgggtt ttagaaataa cttgtaaagc agactggacc     6420

caaggccgcc ttcagtgtca agaagggcat tgtgacttgc ccctcaattt ctgtccattg     6480

aagtctggtt ttccatgagg aacttgcggg ctcacccacc cccagagtga gagaagagga     6540

aggcgaagtc atcacagaca cggtcttagc cacctgctga actaatccct ccgctattga     6600

gggtcagggt tgtgaggcaa ccatcatgtg tcaccccaaa atataaatgt ttctgagccg     6660

cccatccact ggcatttgga tttgctgcca gagtcctgtt cctcccagaa ccatcccgcc     6720

ctcctgttga ccatgttact tgagtgtagg cccggtgtca agaccctcag agtctttgag     6780

gaaagagcca agcagagaag accgctgcgt ggagtgtgac accacatggc atttctcaag     6840

cccagcggac cctgtgtcag caaataccag taatttaaca tctgctcctg gcctcctctt     6900

cacctgcctg ggttcggaac tgaggaggaa ggatgagaag agactgcaat gcagcaggca     6960

ccctctgcag agtgaggccg cccgtccatc actgccagcc ctgggctgct caggagggga     7020

cgtgaaccac tcaaaggaat gtcttaaaga ggatctggag tttcccccat gcaaattagg     7080

gaagaattag gcaagaaaag acatacatta cagggaaatc cttctgaaca aaatggctgt     7140

cttcacctac tcttcttgca agaaaagaca tacattacag ggaaatcctt ctgaacaaaa     7200

tggctatctt cacctactct tcagcaaaaa ccgtctccag actttttagt gtcaaaaatg     7260

taaccaactg tctcctgatt ttttccaatg tgtttggcaa gtgctgtggc cctgttgtag     7320

gtacttctcc tgactcttgg gggagaagtg gttttaggga ttgatttggg ggagcgggtt     7380

tttgtcccat cccacctcct ctcttctttc tctgcttgtc gatattgtct gtgtgattca     7440

gagaattggg gcagttacat tgtgtctgtt gttgagatta ttaaaagatt aaaacgtagt     7500

tgtagaaatg aaaaattaaa cagctgtgtt ttaaaaatgc aaaccaatat cttgttaata     7560

aaggaattca agctatgggg cagccacact cccctcctcc caggctggca taggtggccc     7620

tgggctggcg gcttaggaag catggagcac acttagggta gtgcctgcct gggcaagaga     7680

cacctgccga gcaaaaggaa cgagaatctg gggctcagag cctcgcagtt gtgccaggat     7740

tttcctatac atgttcagga cctctgggta gaggtttcac agtttgtgac cccataacca     7800

ccctcacccg acgtgggttc tagctcagtg tgcctaatac tgcatggtaa cctgggcttg     7860

accctgaagc ccctgcctgg caggccacag gacctctcct gcccacttgg tgctatctct     7920

tccagtgacc acccagcacg ggtgagcact ggccagcctg gagcctgcaa tccaggtgga     7980

acagactgtc ctccatgtca gttccttctg gcttcaggcc ctcaattatt tccctttgag     8040

cttttttaga ccctagatct cctaggccca ggctctctct tgaccccaga gaagccactg     8100

tcaggaaagg aagtgaaccc tactgaagcc agagaattca ccccggccaa agcaggccct     8160

ctgggtccag cccctcattc cacaccacgc cagtattgca tccatctact gcagctacac     8220

atcctgaggg cagcaccacc cactctggcc tgctggccca tcgcaggact agcccaggca     8280

cctgccgggc attgcaggat atccagtggg gcctgtgact gctccctgat gcgtcagaag     8340

agaagtgttg cactttagtg gaggagctga ggagcacctg cccccttgta gcttgagttc     8400

cttttggtaa cagtagcagc ctccatggtg gtgtctggga tgcacgtgca cccgctgcct     8460

tcagctgtat gtgtgtgttc ctgctggagt tgtgttactg acaggataat gacattacaa     8520

agaaattgtg ttatattcaa ctttgccttg ataattattg taaacacttt gttcattttt     8580

tcttttttat tcacaaacta aatccaccag gaaattataa agttattt                  8628


<210> 673
<211> 4848
<212> DNA
<213> Homo sapiens

<400> 673
cggtcactcc aggctgcctc gctgcgccgc tggcggtggg cgtggcgctg ccggcggcta       60

ggcgcggacg ccggaggagg tgtccccggg tttaggggtg ttcggccagg ggcggggctg      120

ccgggcccgg gcgactgccg gagctgcgga agtcgtggaa gcgtcggcga cgcatcgcgc      180

gatggcgcgg gcgggacagt gcttgtgaaa ctgaacacaa caaaagtatg gatatgggaa      240

accaacatcc ttctattagt aggcttcagg aaatccaaaa ggaagtaaaa agtgtagaac      300

agcaagttat cggcttcagt ggtctgtcag atgacaagaa ttacaagaaa ctggagagga      360

ttctaacaaa acagcttttt gaaatagact ctgtagatac tgaaggaaaa ggagatattc      420

agcaagctag gaagcgggca gcacaggaga cagaacgtct tctcaaagag ttggagcaga      480

atgcaaacca cccacaccgg attgaaatac agaacatttt tgaggaagcc cagtccctcg      540

tgagagagaa aattgtgcca ttttataatg gaggcaactg cgtaactgat gagtttgaag      600

aaggcatcca agatatcatt ctgaggctga cacatgttaa aactggagga aaaatctcct      660

tgcggaaagc aaggtatcac actttaacca aaatctgtgc ggtgcaagag ataatcgaag      720

actgcatgaa aaagcagcct tccctgccgc tttccgagga tgcacatcct tccgttgcca      780

aaatcaactt cgtgatgtgt gaggtgaaca aggcccgagg ggtcctgatt gcacttctga      840

tgggtgtgaa caacaatgag acctgcaggc acttatcctg tgtgctctcg gggctgatcg      900

ctgacctgga tgctctagat gtgtgcggcc ggacagaaat cagaaattat cggagggagg      960

tagtagaaga tatcaacaaa ttattgaaat atctggattt ggaagaggaa gcagacacaa     1020

ctaaagcatt tgacctgaga cagaatcatt ccattttaaa aatagaaaag gtcctcaaga     1080

gaatgagaga aataaaaaat gaacttctcc aagcacaaaa cccttctgaa ttgtacctga     1140

gctccaaaac agaattgcag ggtttaattg gacagttgga tgaggtaagt cttgaaaaaa     1200

acccctgcat ccgggaagcc aggagaagag cagtgatcga ggtgcaaact ctgatcacat     1260

atattgactt gaaggaggcc cttgagaaaa gaaagctgtt tgcttgtgag gagcacccat     1320

cccataaagc cgtctggaac gtccttggaa acttgtctga gatccaggga gaagttcttt     1380

catttgatgg aaatcgaacc gataagaact acatccggct ggaagagctg ctcaccaagc     1440

agctgctagc cctggatgct gttgatccgc agggagaaga gaagtgtaag gctgccagga     1500

aacaagctgt gaggcttgcg cagaatattc tcagctatct cgacctgaaa tctgatgaat     1560

gggagtactg aaataccaga gatctcactt ttgatactgt tttgcacttc atatgtgctt     1620

ctatgtatag agagctttca gttcattgat ttatacgtgc atatttcagt ctcagtattt     1680

atgattgaag caaattctat tcagtatctg ctgcttttga tgttgcaaga caaatatcat     1740

tacagcacgt taacttttcc attcggatca ttatctgtat gatgtggtgt ggtttgtttg     1800

gtttgtcctt ttttttgcgt ttttaatcag aaaacaaaat agaggcagct tttgtagatt     1860

ttaaatgggt tgtgcaagca ttaaaatgca ggtctttcag aatctagaac taggcataac     1920

cttacataat actaggaaaa ttatgagaaa ggggaaattt ttggttaaat aagagtaagg     1980

ttcaaacaca agcagtacat gttctgtttc attatgctcg atagaaggct tttttttcac     2040

ttataaggcc tgattggtcc tacccagctt aacggggtgg ggtttttttg tttgttcaga     2100

cagtctgttc ttttgtaaac atttttagtt ggaaaaacag catctgcatt ttccccatcc     2160

tctacgtttt agagaggaat cttgtttttg tgtgcaacat aagaaaatta tgaaaactaa     2220

tagccaaaaa acctttgaga ttgcattaaa gagaagggat aaaggaccag caataatacc     2280

ttgtaagttg cttttgtttg taaaatctga gcttatagtt ttccttagtg agtaaattca     2340

taaggatggg aacatttaaa ttaagttaat gggcctttaa aaaaaaaaaa aggaaacact     2400

catacctgta gttggaggat gaatactgga gacgggttac caatgtcagg ttatactaaa     2460

actaaatcag aaagtctgaa tgtagcacat aatggttctc ttctgttgtc caaggctgta     2520

aaatggacag ccttgtcaca cctccccggt gctgttttac aacgtgaggg tagacgctgt     2580

cagtaaccca gagggaccag gccttcctag gttttctagg cagtcagctg ttaaccactc     2640

acttagtaaa tgtcataact acacctgctc caggaccaat cagtgaaacc tgctcggaat     2700

taaaggcttc ctctgggtgc ctgctgaaca actgagctca tgtcatgggc atgtggtggt     2760

ttctctgttg cctgaaagag ccattaaagt cagtcgtgcg tgaagcatct ctcttctaaa     2820

ggatgtgtat ttccataaat gctttctgag gatccggtac aaaatgattt cccaaagttc     2880

tgaagtgcct tgagaacatg tgggtccgag tgttataaca gactcctccc ccgggtcacc     2940

ttttgcctgg tcatcctgtt agagtacatc tttggaaatc cagggtaata ttctctttca     3000

gagatgctca ttgtgtaact ctgtgtaggg agatagtcac tttaaacagc tcaaagtagc     3060

tagctaaagg agtagcctta aatacctaaa agatgacaga agcatagccc ttaacaaatc     3120

ttcagcttgt ctctcagtat ttcccaatca tgaaaatccc ttgctatgtc tttcctacta     3180

gaaatgttct agaatcgctg gacggtgggg tcagagggca gtcggtattt aggccgtgag     3240

cttcccatac tactgcaggt ccaactcctg gcaaccgcgg gctcaaggca ggtcattgga     3300

atccacgttt tggccacagt agttgtagga ttgcttttct gtatcataat tttagaatgc     3360

tcttaaaatc ttgaggaaga gtttttattt tttatttatt tttgagatgg agtctctgtt     3420

gcccaggctg cagtgcagtg gtgccatctc agctcactgc aacctccacc tcccaggttc     3480

aagcgattct cctgcctcag ccacctgagt agctgggagt acaggcatgt ggcaccatgc     3540

ctggctaatt tttgtatttt taatagagtt gagatttcac catgatggtc aggctggtct     3600

cgaactcctg acctcgtgat ccgcccgcct cggcccccca aagtgctggg attaacgggt     3660

gtgagccacg gcgcccagcc caggaagagt ttttaaatta gagctctgtt taattatacc     3720

actgggaaat catggttacg cttcaggcat attcttcccc agagtactac ttacatttta     3780

aatttcattt tgtaaagtta aatgtcagca ttccctttaa aagtgtccat tgttctttga     3840

aagtagacgt ttcagtcatt cttttcaaac aagtgtttgt gtaccttttg ccaagctgtg     3900

ggcatcgtgt gtgagtacag ggtgctcagc tcttccaccg tcattttgaa ttgttcacat     3960

gggtaattgg tcatggaaat gatcagattg accttgattg actgtcaggc atggctttgt     4020

ttctggtttc aatctgttct cgttccttgt accggattat tctactcctg caatgaaccc     4080

tgttgacacc ggatttagct cttgtcggcc ttcgtgggga gctgtttgtg ttaatatgag     4140

ctactgcatg taattcttaa actgggcttg tcacattgta ttgtattttt gtgatctgta     4200

atgaaaagaa tctgtactgc aagtaaaacc tactccccaa aaatgtgtgg ctttgggtct     4260

gcattaaacg ctgtagtcca tgttcatgcc aaaaatggct gggaacgttt gctttattta     4320

cattcagtca gcgttgcttt cagatcacac tttatccaca caggaaagcc agtcagccta     4380

taatgaagta gttattaaaa taaatgtaat gaatatgtct acaaagtata gtttagtggt     4440

ttattttgct aaaatgcaca tatatttgat ataatttagt ttgagaagtt cagctagttt     4500

ttctcctttg tttgactttg tcaatttcta tctggttttt aagggtctga gcttagcttg     4560

tgcatgcaag gttttgggtt tttttatttt ttttttgagc acagcttttc accttttaat     4620

ttgttgggta tttttctctt aataagagaa atattggcca tcgattttta catataatac     4680

aagtgtgttt ttccagtaca ttggttcctg tcccctctct gtgaactgtt tgagtattgg     4740

aacagtatgt cttcaataat tcaatgttac tttgagatac atgtgttaat atacccttag     4800

ttattcttga aataaaacca gtctcttacg cttgcagtgg agaaaggc                  4848


<210> 674
<211> 4469
<212> DNA
<213> Homo sapiens

<400> 674
gcagtcgctg ccgaccggct ggctgggcct tgcggcgtga ggaccccggc ggcgccgcag       60

tcccgcgagc catggcccag tccggcgggg aggctcggcc cgggcccaag acggcggtgc      120

agatccgcgt cgccatccag gaggccgagg acgtggacga gttggaggac gaggaggagg      180

gggcggagac tcggggcgcc ggggacccgg cccggtacct cagccccggc tggggcagcg      240

cgagcgagga ggagccgagc cgcgggcaca gtggcaccac tgcaagtgga ggtgagaacg      300

agcgtgagga cctggagcag gagtggaagc ccccggatga ggagttgatc aagaaactgg      360

tggatcagat cgaattctac ttttctgatg aaaacctgga gaaggacgcc tttttgctaa      420

aacacgtgag gaggaacaag ctgggatatg tgagcgttaa gctactcaca tccttcaaaa      480

aggtgaaaca tcttacacgg gactggagaa ccacagcaca tgctttgaag tattcagtgg      540

tccttgagtt gaatgaggac caccggaagg tgaggaggac cacccccgtc ccactgttcc      600

ccaacgagaa cctccccagc aagatgctcc tggtctatga tctctacttg tctcctaagc      660

tgtgggctct ggccaccccc cagaagaatg gaagggtgca agagaaggtg atggaacacc      720

tgctcaagct ttttgggact tttggagtca tctcatcagt gcggatcctc aaacctggga      780

gagagctgcc ccctgacatc cggaggatca gcagccgcta cagccaagtg gggacccagg      840

agtgcgccat cgtggagttc gaggaggtgg aagcagccat caaagcccat gagttcatga      900

tcacagaatc tcagggcaaa gagaacatga aagctgtcct gattggtatg aagccaccca      960

aaaagaaacc tgccaaagac aaaaatcatg acgaggagcc cactgcgagc atccacctga     1020

acaagtccct gaacaagaga gtcgaggagc ttcagtacat gggtgatgag tcttctgcca     1080

acagctcctc tgaccccgag agcaacccca catcccctat ggcgggccga cggcacgcgg     1140

ccaccaacaa gctcagcccg tctggccacc agaatctctt tctgagtcca aatgcctccc     1200

cgtgcacaag tccttggagc agccccttgg cccaacgcaa aggcgtttcc agaaagtccc     1260

cactggcgga ggaaggtaga ctgaactgca gcaccagccc tgagatcttc cgcaagtgta     1320

tggattattc ctctgacagc agcgtcactc cctctggcag cccctgggtc cggaggcgtc     1380

gccaagccga gatggggacc caggagaaaa gccccggtac gagtcccctg ctctcccgga     1440

agatgcagac tgcagatggg ctacccgtag gggtgctgag gttgcccagg ggtcctgaca     1500

acaccagagg atttcatggc catgagagga gcagggcctg tgtataaata ccttctattt     1560

ttaatacaag ctccactgaa aaccaccttc gttttcaagg ttctgacaaa cacctggcat     1620

gacagaatgg aattcgttcc cctttgagag attttttatt catgtagacc tcttaattta     1680

tctatctgta atatacataa atcggtacgc catggtttga agaccacctt ctagttcagg     1740

actcctgttc ttcccagcat ggccactatt ttgatgatgg ctgatgtgtg tgagtgtgat     1800

ggccctgaag ggctgtagga cggaggttcc ctgggggaag tctgttcttt ggtatggaat     1860

ttttctctct tctttggtat ggaatttttc ccttcagtga ctgagctgtc ctcgataggc     1920

catgcaaggg cttcctgaga gttcaggaaa gttctcttgt gcaacagcaa gtagctaagc     1980

ctatagcatg gtgtcttgta ggaccaaatc gatgttacct gtcaagtaaa taaataataa     2040

aacacccaac tgggagtgct gactttgagg ttatagattg tgcctgacaa aagtctgtgc     2100

ctgtctgaca gagctgtggg tggtatgtca tgaggccctg aggagcttag cagagacatc     2160

tttcttttct ttaagagaac atttaaaaat ttttttattt gtacacattt atgggctaca     2220

tgagaaactt tgttacatgt ttataatgca tagtgatcaa gtcagggcat ttagggtttc     2280

tcactgtacc ccagggcagc cccagggctc tccttgggct tctggcagcc tgagtggtgt     2340

ctcatcacag ggaattttac tgagcaaagg cagcttggcg tatactgagg gtgtacagtc     2400

caggacccac agcattgatc tcacctggga acttattaga aatccagatt ctcaggccaa     2460

ccctaggccc actgaattag aaagtctggg agaaaggcct ggaatttggg ttttaacaaa     2520

cgctgcaggt gattctgatg cacgctggag aaccactgga tggacaaagg ctgcaggact     2580

tgaggtcagt ccatttgacc cccaatctct cactattttg tgaccttggg aaggttacta     2640

agccccgtga acctcatcat ctccctgtga attgctttgt tacgatgtcc atgtctggaa     2700

tgcagctggc cctccataaa tgttagctct ctttccttct cacttgggtt aatgtttgtt     2760

atcatcagga gctgccttgg tgtagcagaa agagcattgg cctagattcc agtgttggct     2820

tatgctctgg ctatttggca ggatttaata gagcttgtta ataattattg aacagtgatt     2880

aggtgccagg gactatgcta agagctttcc atgcattatc tcatttaatc tgcccaaaaa     2940

ctacaagaga aatgttcagg tattatctct attttattcc agaaaaaaac agactttact     3000

tgggtaatta acttgtctaa ggcttaacag ctaaattggt agagttgggc ttgaaactag     3060

tggtctggct ttggagccca cactgtttaa ccactaagtg gtactcaaca tttctgatct     3120

ttactatcca tattcaaaaa agaatccacc ataaaaggtg ctaatattta ttcagcacct     3180

tcctacgtgc taggcattgg gttagacaca tttcacttac tctcagtgtc catcataagg     3240

aattattatg ccagtatcac acatgcagct gctgaagtag gaaaataata tcccaaactt     3300

gtgaaaatgg acaaagatag tatatcctaa atgatatggc tctatacaaa ttagcaggtg     3360

attgtgatct ggatagtaag atgctttgtc ccttaagatg cagaagagtt cgtgttaact     3420

ggcaaatgcc tccagcaatg ttctggattt gccatttcca gcactaccag ctgtaggtag     3480

cctgaaggct tgtgcctaga ccaccaggac tcctgacctt gggcaatgtc agggccccct     3540

ccagccccgc cctatgcttc cctccctgac tctgctccca tcaccccctg cctgctcctt     3600

ccctgcagcc actccacctg ctccttggcc atcgggccat ctgggcttca ccagctcttc     3660

ttggcctgtg acattcaagg ctgttccacc ctattatgcc tgttacacaa gtcacagctc     3720

tatttttaga ttaaccctcg tggatcatag ttacttttaa aaatacctac accctcacct     3780

ttacatgtga atacagatga acttggcctt cctttggtcg tattgccctg tgtgacatta     3840

taaaagaacc ctgaagtggg ggtcagcaga tctgaggtcg agtcgtggct tttctactaa     3900

gcaactgtga ccttcagcaa gtcatttatt ttattggttc acagttcttc ccacaaacca     3960

gtggataaca agaagatgtt ccttaaataa ggtcatatat gtgcaagtgc tttctgaatg     4020

gaaaagtgct ttgcaggcat tagtcactac ttatcctgct gtctgatcat cacctccaaa     4080

ggcaagcctc cttttgctgc aattcttaac cctggcctca cattagagtc acctaaagag     4140

cttttaaaaa ctgcctatgg ggctgggcac ggtggctcac gcctgtaatc ccagcacttc     4200

aggagactga ggcgggcaga tcatgaggtc aggagattga gactatcctg gctaatgtgg     4260

taaaaccctg tctctactaa aaatacaaaa aaattagccg ggcatggtgg cacgcacctg     4320

taatcccagc tacttgggag gcggaggcag gagaattgct tgaacctggg aggcggaggt     4380

tgcagtgagc cgagatcacg ccgctgcatt ccagcctggg caacagaatg agactccatc     4440

tcaaaaaaat aaaaataaaa ataaacaaa                                       4469


<210> 675
<211> 1006
<212> DNA
<213> Homo sapiens

<400> 675
cggggtggga ttccaaccca gaagcgggca tttggagccc tcatgcttca ccctagctcc       60

ctgaaacaag cacggaggat ggctctgagc agcgaggaaa gtgctggaag caagcaggcc      120

gagcgcgtcc ctggctgggg acgttaatca ttaccggagg gcggcccgag cgcggccccg      180

ccccgggacg gcagcctgcg cgcccggccg ccgcctgccc tctccgctgg ccacctgctg      240

ccgcccgcgc catggctggc aaagcacaca ggctgagcgc tgaggagagg gaccagctgc      300

tgccaaacct gagggctgtg gggtggaatg agctggaagg ccgtgatgcc atcttcaagc      360

agtttcattt caaagacttc aacagggcct ttgggttcat gacaagagtg gccctgcagg      420

ctgagaaact ggaccaccat cctgaatggt ttaacgtgta caacaaggtc cacatcacgc      480

tgagcaccca tgagtgtgcc ggcctttcag aacgggacat aaacctggcc agcttcatcg      540

aacaagtagc agtgtccatg acatagaccc tgcccttcct ctttgaattc ttccggggga      600

aggggtgact gaactgggag tccagggagg gagctgagga gcccttaccc tcccaccact      660

cccctcccaa gacccagccg ccgccgttga gggctgagtc cttgctgtgg gatgtgccag      720

tgtccccacc aacaccagga atttagacct tttccctgca ccactctctt catcctgggg      780

gctctgttac actaatttga ataaactctc ccctttcttt gcaacttccc agcaacaata      840

atgattttct tgccaggccg tctcttgctc cctaattcat ttcccaggaa gctgtgatac      900

agggtgaaat aaagtcttgt cttagaaacc aggaccctaa accccacact atgtaataga      960

aacacatgtg tttttatgtc tcaaataaaa ctattatatc acttgg                    1006


<210> 676
<211> 1176
<212> DNA
<213> Homo sapiens

<400> 676
aggtggcagc gcttgcagtc gggctacgga ggccgggttg ccagattacg ggaaagccat       60

ttaagaagtt cctggaataa tattagtcag agtaatatag gatctgcagg aagtgtctca      120

agatagttgg aaaagaagaa tttctagact cttcatcaag atcttcattt atacagctgt      180

taaatccaag gctactttgg tgaaagcatg aataaaaata catctactgt agtatcaccc      240

agtctacttg aaaaggatcc tgcctttcag atgattacaa ttgccaagga aacaggcctt      300

ggcctgaagg tactaggagg aattaaccgg aatgaaggcc cattggtata tattcaggaa      360

attattcctg gaggagactg ttataaggat ggtcgtttga agccaggaga tcaacttgtc      420

tcagtcaaca aggaatctat gattggtgta tcatttgaag aagcaaaaag cataattacc      480

ggagccaagt tgagtactag gttagaatct gcttgggaga tagcattcat aagacaaaaa      540

tccgacaaca ttcagccaga aaatctgtca tgtacatcac ttatagaagc ttcaggagaa      600

tatggacctc aagcctcaac attaagtctt ttttcttctc ctcctgaaat actaatccca      660

aagacctcat ccactcccaa aacaaataat gacattttat cttcttgtga gataaaaact      720

ggatacaaca aaacagtaca gattccaatt acttcagaaa acagtactgt gggtttgtct      780

aatacagatg ttgcttctgc ctggactgaa aattatgggc tacaagaaaa gatctcccta      840

aatccctctg ttcgctttaa ggcagagaaa ctggaaatgg ctctaaatta tcttggtatt      900

cagcccacaa aggaacaaca ccaagccctg agacagcaag tacaagcaga ctcaaaaggg      960

acagtgtctt ttggagattt tgtccaggtt gccagaaact tgttttgctt gcagttggat     1020

gaagtaaatg ttggtgcaca tgaaatttcc aatatattag attcacagct tcttccttgt     1080

gattcttcag aagcagatga aatggaaagg ctcaagtgtg aaagagatga tgccttgaaa     1140

gaagtaaata cacttaagtg gccagggcag aattag                               1176


<210> 677
<211> 1660
<212> DNA
<213> Homo sapiens

<400> 677
cggcggatgt ttacggcggc cgaggttgga gcggcgctgc tcggccgcgg acacacgagg       60

gacgcgcccg aggagctgca ggtggcagcc caggcggtcc gaacccgtcg gccggccgag      120

cctggagtat tgcctaagtg taatcttgaa catgggcggt gctgtgagtg ctggtgaaga      180

caatgatgag ctgatagata atttgaaaga agcacagtat atccggactg agctggtaga      240

gcaggctttc agagctatcg atcgtgcaga ctattatctt gaagaattta aagaaaatgc      300

ttataaagac ttggcatgga agcatggaaa cattcacctc tcagccccgt gcatctactc      360

ggaggtgatg gaagccctag atctgcagcc tggactctcg tttctgaacc tgggcagtgg      420

cactgggtat ctcagctcca tggtgggcct cattctaggt ccttttggtg tgaaccatgg      480

ggtggaactt cactcagatg tgatagagta tgcaaagcag aaactggact tcttcatcag      540

aacaagtgat agttttgaca agtttgactt ctgtgaacct tcctttgtta ctgggaattg      600

cctggagatt tctccggatt gttctcagta tgatcgtgta tactgtgggg ctggcgtgca      660

gaaagagcat gaagagtaca tgaagaatct tctcaaagtg ggagggatcc ttgtcatgcc      720

actggaagag aagttgacta agataacacg cacaggtcct tcagcttggg aaaccaaaaa      780

gattcttgct gtttcttttg ctcctctgat ccagccctgc cattcagagt caggaaaatc      840

aagacttgtc cagttacggt ctccctcttt tgtccaaggc tggagtgtgg tagtgctatc      900

acagctgact gcagcctcaa ccttccaggc tgaagcgatc ctcccatctc aatctcctac      960

gtggctgaca ctacaggtgc ttgccactat gcccaactaa catttggaat tttcgtatac     1020

gtggattcta gaggggtgac agcgaaacct gcaggacaaa ttcgagcatc ttaaaatgat     1080

tcaacaggag gagataagga agctcgagga agagaaaaaa caactggaag gagaaatcat     1140

agatttttat aaaatgaaag ctgcctctga agcactgcag actcagctga gcactgatac     1200

aaagaaagac aaacatcgta agaagcaata gtttctctta ctattctgag agccttatca     1260

ttctacatcc catcttcctg tgagattgtc tttgtagcat ttaactctaa ttgcagttct     1320

ctttttaaaa attggcttgc ttattgtata ttttccccaa ctaaagcgtg aactcctagc     1380

agggcgtggt ggctcatgcc tgtaatctca gcactgtggg aggccgaggt gggtcgacta     1440

cctgaggtca ggagttcgag accagcctga ccaagatgat gaaacgctat ctctactaaa     1500

aatacaaaaa ttagctaggc gtggtggctg ggacctgtaa tcccagctac ttgggaggct     1560

gaggcaggag aatcacttga accctggagg tggaggttgc agtgagccga gatctcacca     1620

ttacactcca gcctgggtga caagagcaaa actccatctc                           1660


<210> 678
<211> 1973
<212> DNA
<213> Homo sapiens

<400> 678
agccgccgcc tcgccgcttc ccctcgtcgg agcggccgct cgtccgcccg gcttgaggcc       60

cgcggggagc gcggcgcaat tcgtcggccc gcgggggggc ggcctcccgg catcttcgcg      120

gcgaccaagg actaccagga aggggagcgg ctgggatggc gcgtccgcgg ccccgcgagt      180

acaaagcggg cgacctggtc ttcgccaaga tgaagggcta cccgcactgg ccggcccgga      240

ttgatgaact cccagagggc gctgtgaagc ctccagcaaa caagtatcct atcttctttt      300

ttggcaccca tgaaactgca tttctaggtc ccaaagacct ttttccatat aaggagtaca      360

aagacaagtt tggaaagtca aacaaacgga aaggatttaa cgaaggattg tgggaaatag      420

aaaataaccc aggagtaaag tttactggct accaggcaat tcagcaacag agctcttcag      480

aaactgaggg agaaggtgga aatactgcag atgcaagcag tgaggaagaa ggtgatagag      540

tagaagaaga tggaaaaggc aaaagaaaga atgaaaaagc aggctcaaaa cggaaaaagt      600

catatacttc aaagaaatcc tctaaacagt cccggaaatc tccaggagat gaagatgaca      660

aagactgcaa agaagaggaa aacaaaagca gctctgaggg tggagatgcg ggcaacgaca      720

caagaaacac aacttcagac ttgcagaaaa ccagtgaagg gacctaacta ccataatgaa      780

tgctgcatat taagagaaac cacaagaagg ttatatgttt ggttgtctaa tattcttgga      840

tttgatatga accaacacat agtccttgtt gtcattgaca gaaccccagt ttgtatgtac      900

attattcata ttcctctctg ttgtgtttcg gggggaaaag acattttagc cttttttaaa      960

agttactgat ttaatttcat gttatttggt tgcatgaagt tgcccttaac cactaaggat     1020

tatcaagatt tttgcgcaga cttatacatg tctaggatcc ttttatcaag gcagttatga     1080

tcatcgtttt cctgccttga ccccaccatc atcaaacact cagttaaata taaattaaca     1140

ttttttagat gaccactcaa cataatgctt aagaatggaa tttcctctct gtgacagaac     1200

ccaggaatta attcctaaat acataacgtt ggtatattga agacgaaatt aaaattgtcc     1260

ttcagttttg aggccatgtg taaagtttaa ccatattgta aaatatctat tccgtattag     1320

aaatagctag ttgacagctt atacttctca aaattcatat tgttatgtac acaaactaag     1380

tttctatatg tgaagttagt gagtcttttt gtgttactcc aaaataaagg caatgattta     1440

tttttttccc agtgccaata caattttgag ctaagcactc aaggtggata ctttacattt     1500

taaagctgga atcagcaaca gccctatggg aaaccagaca aagcattgac ttttaaatgt     1560

agacttttaa aataaactgt tttcttttgg aactacaatt agaatagtta atattcatcc     1620

ttaaaccatt attatgtgta cattattgtt gctattgtga taatagagaa ttttatttat     1680

ttttatgcca gcttatattg tgagaacaca tttagtcagt ttgggtttta tcaatcctgt     1740

taatgcttgt ccttggaaca tctttcgcgt attcacggtt tgtagttgaa aagtttactg     1800

taaaaaaatc aaaaacaaaa aaatgtattg tttttacaga ataaatttat tggaatgtgt     1860

actgggagta agatttgagg ttgtaagcaa actaagttag tgtaatttgg cttcatatat     1920

gtaacgtgag gtattaatgt aattcatata ttaaagcaaa aattgttcac agc            1973


<210> 679
<211> 1020
<212> DNA
<213> Homo sapiens

<400> 679
cctggttgct gggtgcaaag tgctgggttc tgggtttctg gattcgcggg ccgttcacac       60

gtagcctgtg ccggctcctc gggtgagtcc gtccgcgcgc ggtgccccgg gacggcctag      120

gctgccgggg gtccggggcc ccaggcattc cgggctgcag attgacgggg atcccggatg      180

caccgcgcgc ccccgcgccc tcaccgacgg gtccagacct ggtgggaaga aggtgcgggg      240

acgggtccct gaggatcccg atgcctacga gccaagatgc tcagctttat aggtgtgacc      300

tacacatgtg acttcacctc agttttgtga tccgtaaaat ggacaaattc gaagctactt      360

cacagtgctg ttgagaggat taaatgaaac aatgcttgta aagctctttg caggagggag      420

cctcggaagc agggcctggc cggcagagca cacctgctgt caccagggac cacaggcagc      480

atgaagaccc ccgtggagct ggccgtcagt gggatgcaga ccctcggcct tcagcaccgc      540

tgccgaggtg gctaccgggt caaggccagg acgtcatatg tggatgagac tctgtttggc      600

agcccagcag gcacccggcc taccccaccg gacttcgatc cgccctgggt ggagaaggct      660

aacagaacca gaggcgtggg caaggaggca tcgaaggcct tgggggcaaa ggggagctgt      720

gagaccaccc cctcaagggg cagcaccccc accctcacac caaggaagaa gaacaaatac      780

agacccatca gccacacccc gtcttactgt gatgagtcgc tgtttggctc ccgatctgaa      840

ggcgccagct tcggggcccc gcggatggcg aagggggatg ccgcaaagct ccgtgctctc      900

ttgtggacgc caccacctac ccccaggggt agccactcgc cccgccccag ggaggcacca      960

ccaccagtgc cccccacaca aatgggcctc aggatctcag gccttccacg tcaggggtga     1020


<210> 680
<211> 1301
<212> DNA
<213> Homo sapiens

<400> 680
agaatggcct cggacaccca ggcagtccct gacgtgtcgg ggaggagccg ggcgcggagg       60

tacgctgagt ggagctcggg gctgcgtagg ggagctgagc cgagcggctg ggcgggcctg      120

gccgggccgg cggaggggag acgtcggttg agcggcggcg aacatgcgct tttgacacat      180

tggaggcttt cttgatcatg gatggtgaag atataccaga tttttcaagt ttaaaggagg      240

aaactgctta ttggaaggaa ctttccttga agtataagca aagcttccag gaagctcggg      300

atgagctagt tgaattccag gaaggaagca gagaattaga agcagagttg gaggcacaat      360

tagtacaggc tgaacaaaga aatagagact tgcaggctga taaccaaaga ctgaaatatg      420

aagtggaggc attaaaggag aagctagagc atcaatatgc acagagctat aagcaggtct      480

cagtgttaga agatgattta agtcagactc gggccattaa ggagcagttg cataagtatg      540

tgagagagct ggagcaggcc aacgacgacc tggagcgagc caaaagggca acaatagttt      600

cactggaaga ctttgaacaa aggctaaacc aggccattga acgaaatgca tttttagaaa      660

gtgaacttga tgaaaaggaa tctttgttgg tctctgtaca gaggttaaag gatgaagcaa      720

gagatttaag gcaagaacta gcagttcggg aaagacaaca ggaagtaact agaaagtcgg      780

ctcctagctc tccaactcta gactgtgaaa agatggactc cgccgtccaa gcatcacttt      840

ctttgccagc tacccctgtt ggcaaaggaa cggagaacac ttttccttca ccgaaagcta      900

taccaaatgg ttttggtacc agtccactaa ctccctctgc taggatatca gcactaaaca      960

tcgtggggga tctcttacgg aaagtagggg ctttagaatc caaattagca gcttgcagga     1020

attttgcaaa ggaccaagca tcacgaaaat cctatatttc agggaatgtt aactgtgggg     1080

tgctgaatgg caatggcaca aagttctctc gatcagggca tacatctttc ttcgacaaag     1140

gctcctcctc cagctgtgcg atccgagctt ccagacgccg cttctcatcc agcagcgcgg     1200

acctggcggg gagaggagga ggggacggtt caatcccagc tcagcacagc acaggagcct     1260

cagggaaggc tcctccaccc accctgttgc tggaaacctg a                         1301


<210> 681
<211> 2382
<212> DNA
<213> Homo sapiens

<400> 681
caggtctccc aggcttcctc agcgtcgacg ccggggagcg ccctggggtt gggagcgccc       60

ggggcccgcg aaggaggagg tggctcaggt gtcagggcgc accgtgggaa ccggccccgg      120

gggaggcgtg gaaacgcggg gcctgggact cgaccagcct ctcccgtgcg gatcgcaaaa      180

tctcggagct gaaacagccc gttgttcgca gcctccctct gacccgccac cctgcacatt      240

gttttccatt cgcccgggtc gcgggtggga ggagaggcac gccggggttc tggagcttgg      300

ccgcgcgcca ggcttgtggc cttcgtcccc ctggggccac tggggcggcc acgcctctcc      360

ggcgggagga gagaacgcgt gggtccgggt ggctgctccg gcccttccgc ctccagctcg      420

gccatggggt cgcgcagctc ccacgccgcg gtcattcccg acggggacag tattcggcga      480

gagaccggct tctcccaagc cagcctgctc cgcctgcacc accggttccg ggcactggac      540

aggaataaga agggctacct gagccgcatg gatctccagc agataggggc gctcgccgtg      600

aaccccctgg gagaccgaat tatagaaagc ttcttccccg atgggagcca gcgagtggat      660

ttcccaggct ttgtcagggt cttggctcat tttcgccctg tagaagatga ggacacagaa      720

acccaagacc ccaagaaacc tgaacctctc aacagcagaa ggaacaaact tcactatgca      780

tttcagctct atgacctgga tcgcgatggg aagatctcca ggcatgagat gctgcaggtt      840

ctccgtctga tggttggggt acaggtgaca gaagagcagc tggagaacat cgctgaccgc      900

acggtgcagg aggctgatga agatggggat ggggctgtgt ccttcgtgga gttcaccaag      960

tccttagaga agatggacgt tgagcaaaaa atgagcatcc ggatcctgaa gtgactccgt     1020

ttgtgccttg ggcttgctcc tgcaaccagt atctccttgg aattcatcca aagcccccat     1080

ggacgcatgg acgcagggcg acaataaact gtattttcgt ttctaactct atttagggcc     1140

aagagaagaa agctggaagg atgtgtacta aagtctagct cagcagtccc caaccttttt     1200

ggcatcaggg acagtttttc cacggatggg tgacagggga tggttttggg atgattcaag     1260

tgcattacat ttattgtgca ctttatttct attatgatta cattgtaata tataatgaaa     1320

taattataca actcaccata atgtagaatc agcaggagcc ctgagcttgt tttcctgcaa     1380

ttagacggtc ccatatggga gtgatgggag acagtgacag atcatcaggc attagattct     1440

cataaggagt gcacaatcta gatcctttgg tgtgcagttc acagtaggat ttgggctcct     1500

atgataatct aatgccactg ctgatctgac aggaggcaga gctcaggcgg taatgcaagc     1560

aatggggagt ggctgtaaat atagatgaag cttcagctcg cctgccgctc accttgtgct     1620

gtgcagcccg gttcctaaca gaccacagac cccacaccag gtctatctca tttggtctca     1680

gagctgtgaa tcagccagca atattttagt tgcaaatcac tgaaaaccca actcaaagtg     1740

acttaagtca gaaagaaatt ttatgaattc aggtaattaa aaagtccaga agtatctgcc     1800

tttaggcaca gctggatcca agggcacaaa tgatgtcatc aggctccagt tattctccat     1860

ctcccagctc agctttttct gtctgtaagc ctgattttca ggaaggctct ttcctagtga     1920

tggagatgac caccatcagc tccaggcttc tatcctgcta acccagtaac ccagtgggaa     1980

gagatttact tattccaata attccaagtg gagagtgtca ttgacccgtt tggggtctca     2040

tctctacttc taggggaatg aaacactctg agtggccagg cctgtgtcat gtgctaattc     2100

ctagagccag ggaaataagg tctgaggatt caggatgggg tgaaaggtgg ttgcttaaag     2160

gaaaatgaaa tacaattagc agaataaggg gaaacgagtg gtctgctctg ctcgggcaaa     2220

acaagagatg cccattactg tgagggaccc ttgaagtctg gactcttaaa tgggtttttg     2280

ctgatttcct gggtgcatgc taggatgatg gggcttgatg cagtagggaa gagacgatgt     2340

aaaaataata aacaatatat accttcctag agtgtgaatg ca                        2382


<210> 682
<211> 4072
<212> DNA
<213> Homo sapiens

<400> 682
acccgcgcgc ggaggagccg gggagtcagc gcttcttccc tccctccccc tctcccctcc       60

ccgctccctg cccccctccc caagaatgtt ccgctacgag tctttggagg attgtcctct      120

ggatgaagat gaagatgcat ttcagggact gggagaagaa gatgaagaga ttgatcaatt      180

caatgatgat acatttgggt caggtgcagt tgatgatgat tggcaggaag cacatgagcg      240

cctggctgaa ttggaagaaa agctaccagt ggcagttaat gaacaaacag gcaatggaga      300

gagagatgaa atggacttgt tgggtgacca tgaggagaat ctggcagaaa ggctcagtaa      360

gatggtgatt gaaaatgaac tagaagatcc agctattatg agggcagtgc agaccaggcc      420

agttttacaa ccccaaccag gaagtctgaa ttccagtatc tgggatggat ctgaagttct      480

gaggcgaatc cgaggaccac tgcttgctca ggaaatgcct acagtgtctg tattagaata      540

tgctttgcct cagaggcccc cccagggtcc agaagatgat cgggaccttt ctgaacgagc      600

attaccaagg cggtcaactt cacctatcat tggcagtcct cctgttagag ctgtccccat      660

aggcacccca cctaaacaga tggctgtacc cagcttcacc caacagattc tgtgtccgaa      720

gcctgtccat gttcggcccc caatgccacc tcgttatcct gctccctatg gtgagaggat      780

gtctccaaac cagctctgca gtgtcccgaa ctcttccctc ctgggtcacc cttttcctcc      840

tagtgttcct cctgttctca gccccctcca gagagcacag cttcttggag gagcacagct      900

acagcctgga cggatgtctc ccagccagtt tgcacgggtc cctggatttg ttggtagtcc      960

acttgctgcc atgaatccca agttgctaca agggcgagtt gggcagatgc ttcccccagc     1020

accaggcttc cgtgccttct ttagtgctcc accctccgct acaccacctc cacagcagca     1080

ccctcctggc ccaggacccc acctgcaaaa cctaagatct caggccccaa tgtttagacc     1140

ggacacaact cacctccatc cacagcaccg tcgactcttg catcagagac agcaacagaa     1200

tagaagtcag catcggaatc tcaatggtgc gggagataga ggaagtcacc ggagcagtca     1260

tcaagatcat ctccgaaagg atccatatgc caatctcatg ttgcagcggg aaaaggattg     1320

ggtctctaaa atccagatga tgcaactgca aagcactgat ccctacctgg atgattttta     1380

ttaccagaat tactttgaaa aactggagaa actgtcagct gctgaagaaa tacaaggtga     1440

tggccctaag aaggagcgca ccaagcttat cacccctcag gtggccaaac tggagcacgc     1500

ctataagcca gtgcaatttg agggctcttt gggaaagctt accgtttcta gtgtgaataa     1560

tccccgaaaa atgattgatg ctgttgtgac atctcggagt gaggatgatg agacaaaaga     1620

aaaacaagtt cgagacaaga ggagaaaaac ccttgttata attgagaaaa cctacagctt     1680

actccttgat gtggaggact atgaaagacg ttatctccta agtctggaag aagagcgacc     1740

tgccctaatg gatgacagaa agcacaaaat ttgtagcatg tatgacaact taagggggaa     1800

attgcctgga caagagaggc ctagtgatga ccactttgta cagatcatgt gtatccgaaa     1860

agggaagaga atggttgccc gtattcttcc tttcctctcc acagagcaag cagctgacat     1920

tctcatgaca acagccagga acctcccttt ccttatcaag aaggatgcac aagatgaggt     1980

gctgccatgc ttactgagtc ccttctctct ccttctctat catcttccat cagtgagtat     2040

caccagcctt ttgcgacagc taatgaacct acctcaaagt gcagctacac cagcactctc     2100

caatcctcac ctcactgctg tgctccagaa caagtttggc ctgtcactgc tcctcatcct     2160

cctgagccgt ggtgaagacc tacagagttc agaccctgct acagaatcaa cacaaaataa     2220

tcagtggacg gaggtgatgt tcatggcaac acgagaactt ctgcggattc cccaagcagc     2280

cctggccaag ccaatctcta tacctacaaa cctagtgtcc ctcttttctc gctatgttga     2340

ccggcagaaa ctgaacttgc tggagacaaa actgcagcta gttcagggga tacgataaaa     2400

gatctccaaa tgtgtcctgt acctcctttt ggctgccacc tgcactgctg ccatcaccaa     2460

tggagtgttt ttaatgaggg aaggaaggta gctttttccc caaagcaaag tcttgtggga     2520

tcgattcctg tttacagggg ttgtctctct aaatgtcaga tatttcccca ctgctctatg     2580

aaatttggct gggtgatact tctgctggtt tctttacctt ctgtgttaca gttctgcatg     2640

tcctactttt actcagttct gttttgcatt ttctttgccc tagagacaca agtgtaatct     2700

ctccctttat ccctccacta ctccacctca gagtagattg tagcctgcca aaggattcct     2760

tccctcatcc tattgaagtt gttttttcat tgccccatat taatatgact atagaagagc     2820

caattaagta gaaatcaaga tatacacaca cacatagata cacacacaca caccccatac     2880

atgtatttat gtggtcttca gagggtcctt aaagaatgaa ttttagattg aaaaatattt     2940

agttgtctca ttacctcttc taaacacaaa ccagctgatg tattttaatc tgtttctgtt     3000

ctatcttgta attaatttgg tgggttctac ttgttttaac ataaataaag agtatgcagc     3060

acgtttaata aaatcagaac tcttaattgg cttatgccca ggtctaggct gagaagtcct     3120

ttttcttctt cccaccttta tttccttagt ttctgtccac cttaatcgaa acaacacatg     3180

gttatgtctt tttcctgcta caactacagg gtacttgagc ctttcccctc aagtgcattc     3240

gaagtcaccc aggatgatcc tcactagtag cctgctttgg cagtgtggct ttttgcacac     3300

ttgccctgtc ttcctgagac tacttcagta agccatgctt ccttcttccc cacttttatt     3360

tggtgtcatg aatagaaact tccaaatgta accatggaag ctaagtttgg cctgctttgc     3420

tttttagtct ccacaccatg ggcagaactg ctgtctttac tacttcatct cacccaagtc     3480

ccgttcccag gcagccaggg gcctgggttt gaataattgc agggccagcc tgccatgatc     3540

tttctcactt actcctctcc cattcagcaa tcaaccagac taaggagttt tgatccctag     3600

tgattacagc cctgaagaaa attaaatctg aattaatttt acatggcctt cgtgatcttt     3660

ctgctgttct tactttttcg aatgtagttg gggggtggga gggacaggtt atggtattta     3720

aagagaataa acattttgca catacatgta ttgtacaaca gtaagatcct ctgttaaaac     3780

cagctgtcct gttctccatc tccatttctt cccatgctgt aaccccaggc tccaccagct     3840

gttccccagt gatgttacct agcttccctc taccgttgtc tactgaccat ttccactaca     3900

tgcctttcct accttccctt cacaaccaat caagtgaata cttgattatt atctcttcct     3960

tactgtgctt tatctttttt gtttggattg gttctaatta atgaaaataa aagtttctaa     4020

atttacattt ttatagggta ttgtaaataa aaacaaattg tatacttaaa aa             4072


<210> 683
<211> 3727
<212> DNA
<213> Homo sapiens

<400> 683
gccgggtttg ggggttggga cctccggctg caggtccgcc tgggccagac gcgcgagcgc       60

aagcagcggg ttagtggtcg cgcgcccgac ctccgcagtc ccagccgagc cgcgaccctt      120

ccggccgtcc ccaccccacc tcgccgccat gcgcctccgc cgcctagcgc tgttcccggg      180

tgtggcgctg cttcttgccg cggcccgcct cgccgctgcc tccgacgtgc tagaactcac      240

ggacgacaac ttcgagagtc gcatctccga cacgggctct gcgggcctca tgctcgtcga      300

gttcttcgcc ccctggtgtg gacactgcaa gagacttgca cctgagtatg aagctgcagc      360

taccagatta aaaggaatag tcccattagc aaaggttgat tgcactgcca acactaacac      420

ctgtaataaa tatggagtca gtggatatcc aaccctgaag atatttagag atggtgaaga      480

agcaggtgct tatgatggac ctaggactgc tgatggaatt gtcagccact tgaagaagca      540

ggcaggacca gcttcagtgc ctctcaggac tgaggaagaa tttaagaaat tcattagtga      600

taaagatgcc tctatagtag gttttttcga tgattcattc agtgaggctc actccgagtt      660

cctaaaagca gccagcaact tgagggataa ctaccgattt gcacatacga atgttgagtc      720

tctggtgaac gagtatgatg ataatggaga gggtatcatc ttatttcgtc cttcacatct      780

cactaacaag tttgaggaca agactgtggc atatacagag caaaaaatga ccagtggcaa      840

aattaaaaag tttatccagg aaaacatttt tggtatctgc cctcacatga cagaagacaa      900

taaagatttg atacagggca aggacttact tattgcttac tatgatgtgg actatgaaaa      960

gaacgctaaa ggttccaact actggagaaa cagggtaatg atggtggcaa agaaattcct     1020

ggatgctggg cacaaactca actttgctgt agctagccgc aaaaccttta gccatgaact     1080

ttctgatttt ggcttggaga gcactgctgg agagattcct gttgttgcta tcagaactgc     1140

taaaggagag aagtttgtca tgcaggagga gttctcgcgt gatgggaagg ctctggagag     1200

gttcctgcag gattactttg atggcaatct gaagagatac ctgaagtctg aacctatccc     1260

agagagcaat gatgggcctg tgaaggtagt ggtagcagag aattttgatg aaatagtgaa     1320

taatgaaaat aaagatgtgc tgattgaatt ttatgcccct tggtgtggtc actgtaagaa     1380

cctggagccc aagtataaag aacttggcga gaagctcagc aaagacccaa atatcgtcat     1440

agccaagatg gatgccacag ccaatgatgt gccttctcca tatgaagtca gaggttttcc     1500

taccatatac ttctctccag ccaacaagaa gctaaatcca aagaaatatg aaggtggccg     1560

tgaattaagt gattttatta gctatctaca aagagaagct acaaaccccc ctgtaattca     1620

agaagaaaaa cccaagaaga agaagaaggc acaggaggat ctctaaagca gtagccaaac     1680

accactttgt aaaaggactc ttccatcaga gatgggaaaa ccattgggga ggactaggac     1740

ccatatggga attattacct ctcagggccg agaggacaga atggatataa tctgaatcct     1800

gttaaatttt ctctaaactg tttcttagct gcactgttta tggaaatacc aggaccagtt     1860

tatgtttgtg gttttgggaa aaattatttg tgttggggga aatgttgtgg gggtggggtt     1920

gagttggggg tattttctaa ttttttttgt acatttggaa cagtgacaat aaatgagacc     1980

cctttaaact gtcttatttt ccaccagatt gagaaccaga tgttctctac acactatcac     2040

tgttcaatag agctttcttc agtgatggaa atgctctgta atctacactg ttcagtacag     2100

gtagctacgg agcatctgaa atatggctag aaactacatt tttgttttga ttaatttaaa     2160

tagccataca gttgctacca tactggtcac ggcagctgta gactgactgg gtccatagtt     2220

catcacctca aaattctttc aaaatttatt atctctttct ctccttacat gtttatttcc     2280

caggcctacc ctggtgatta gaacagctga agggcctttc ttgttaggct gtccatgccc     2340

taaggatggg ttcctgttta tccttgccac gcagctgagc ttactgcatg tttatatctc     2400

ccaaggactg ttctctgctc agaaatgccc tgtcaagggt gtggcatcac gcagtttcat     2460

ccaagttgtt tcaggaattg ctgacactgc tgggtgcagt tctatcccct aaagcctagg     2520

gtgtggccct ttaacttccc cttcagtaga actgggaaag gcagtaccat tcctagttat     2580

gagtgaagca tccactttct tttgtaacaa tgaggaacag aaaggataag actgaagagt     2640

gatcttttgt ccaactaaac catttatctc cttttgtagg taaattcaaa tcctgcccag     2700

ttatagtttt cagtcactgg agaattccag gtaggagccc tactttaggt gatcctagga     2760

actcctatgt tcagaaaaga attttcttcc tactatataa ttacagtatt tagctgtcaa     2820

ttttaagatg aatttggtag agccttatag taaagtatgt atcttggtca cacacaaagc     2880

ttggaaaaag taaaagatgt ctaaaccata atcttgtaac tcataacatc tgggctgggg     2940

cccggggatc taattgttta gagagcccca aaagtggctc agatgtaaag ccagggttaa     3000

gaaccatctg ccttggaaga tttaagggaa acatataaac ttgtacaaag gacacagaag     3060

cagtcagttt taatttttta gccatgttgg taaaagttca ttttcagtac atgggtaaca     3120

cccaggccct ttcccattat atccaggtat gctacaagtt cttttaactc ttatcagaag     3180

ttattattac tgtttcctta gagaggctac caggctaaaa ttcacttagt ttggtttgtc     3240

taatgtcctc attattttat cctgaagatg atgtcatttc tcaggacttg aaaatgactt     3300

ggctgaacta aaggtaaaaa agccaagcct ctgtcacttt tcctagactc ctaggcacag     3360

ctatggagtc tttgcacagt gcccataccc taaaaattaa taatgaaaac caaacctcaa     3420

gaacctagag cagctctcta cttgccacca tggactccag tggtcagcat aagaaaagca     3480

gatagttgca ttctatttag tttatagctg ctttgttcct ttgtgtttca ctaagcagag     3540

gctcaaaaat tcccttgata acttcagctg cccctgttct tttcctcaaa ctccaggatg     3600

agacctttaa tgtgggacaa tttctggtga aggtactcac agcgacgctt ttcttctctg     3660

taacttgggt actgctgcag agaaaaagca tccatgtcaa aaagtaaaaa ttctcattct     3720

accttgc                                                               3727


<210> 684
<211> 4436
<212> DNA
<213> Homo sapiens

<400> 684
cctgccgcca gaggctccgg gttcacttcc ggcgtgccta cgcctcctct tgcgctgtcc       60

tgttaatggc gggcagtagc cgctgagggg attgcagata accgcttccc gcacggggaa      120

agtctaccct gcctgccact ttctgctcgc cgtcagcgcc ggagctcgcc agcatgtctg      180

tggtaccgcc caatcgctcg cagaccggct ggccccgggg ggtcactcag ttcggcaaca      240

agtacatcca gcagacgaag cccctcaccc tggagcgcac catcaacctg taccctctta      300

ccaattatac ttttggtaca aaagagcccc tctacgagaa ggacagctct gttgcagcca      360

gatttcagcg catgagggaa gaatttgata aaattggaat gaggaggact gtagaagggg      420

ttctgattgt acatgagcac cggctacccc atgtgttact gctgcagctg ggaacaactt      480

tcttcaaact acctggtggt gaacttaacc caggagaaga tgaagttgaa ggactaaaac      540

gcttaatgac agagatactg ggtcgtcagg atggagtttt gcaagactgg gtcattgacg      600

attgcattgg taactggtgg agaccaaatt ttgaacctcc tcagtatcca tatattcctg      660

cacatattac aaagcctaag gaacataaga agttgtttct ggttcagctt caagaaaaag      720

ccttgtttgc agtccctaaa aattacaagc tggtagctgc accattgttt gaattgtatg      780

acaatgcacc aggatatgga cccatcattt ctagtctccc tcagctgttg agcaggttca      840

attttattta caactgaatt cctgcgcagt ggagaagtaa aagaagccgc ttgtctctgt      900

gagcacagct atatacagtg tagaataaat gtggtagaaa agtttttttg gttttatctc      960

ttttgcgatc cctaaattgc cacctttcta ttgtttgaat agtaaaatta atatgaagaa     1020

ctagatagtg gtgtaaacaa atgtgataat gtttatttac tttcggttct gctcatactt     1080

ttttgtacaa cattaaagaa aatggacttt ttttatttta atttctcatt aaacttctaa     1140

aattcttata ggtgaggatc atttttcccc ccaccttagg atggtgaatg ttgcaacaca     1200

atgacaggtt taagtcagtc aagtttattg gacccttgct ttgataccat tcttgggcac     1260

atactccaag attgtattag atttttgtga tgaagagctt ccattacttc tgaaaactat     1320

atttatctga gtgagtccaa ggtgcaactc ctaaatgaat tgtgttgcag agaactccca     1380

gtataattca ctgaccagta cattttataa ccatccaggc cttggtttgc aagcaacaga     1440

ccttaaacat acaggaaact attaaaattg gctcgatcag tagtcatagg aattggtata     1500

agaagagact catttagagc tcagagtttt cttcacataa tgggggtatt aattatttgt     1560

gctgttgcga aattatgtgt cttattctta aagccatggt aaaaataggg atctgtgaag     1620

gaaatttcta aaattggatg tattaggttt tgaactctga gattgcacaa atattcaatt     1680

aacttgaagt tgtgtacata gagaagaaaa tttggtttta gcaaatgaca gagccttcaa     1740

aaatattttt ggaataatgt gaatcaaccg aaaactgggg gcaaggcaga ggacaggttt     1800

tctcaggtta agagaaaaac gaaattttaa aaactttaaa aaatactgat aaattcggat     1860

caaatttggg ggaataaaaa atattagagc aaaggagttt gctggttgtg tcattattta     1920

atgatcaaag tatagcatgt atgccttatt acagacttgt tgactatagg cttaatgtaa     1980

aaaggaatct tgccagatgt agctacttaa ggaaaaaagg gtttttaata gaaatgaact     2040

tttgattagt atggtgccag tcacagggct attttcctga atattgggtg atgtcaaagg     2100

tatatgatac ttgaggaaat caggccaagt gtagctgagc aattaataaa cactcaagtt     2160

tttttagttg gggtcatgtc aaaccctcac atggtggtta agtagtgact aactgtgcat     2220

gtccttcatg gtaggtgagc accagtctcc atgatcaaaa atgccccagt ttcctttgaa     2280

aaagccacta gttctgtgaa ttgtcctttt ccctcctgcc cctaacagtc ctacccctct     2340

agcctacatt agcatatttc tcatgtaatg tattttgctg gtaagctcat ccattagctg     2400

cgtccttcag ctattccttt agattggagg aagtggatat gaagatggat tgattcagct     2460

caccttccat gattgctttt gagggaaaag ctacagtggc cacatttcag atgttcactt     2520

ttgcaatttg tggagggtgg agagaggtag acttttgttg tgtgttttat aaagtactct     2580

cagtaaggag tgtttgagtt gaagagtcat ctgattcgag gccactcatg ttctttgtaa     2640

cttaaacttt gaccaagaaa ttcttcactt ctcacttctt cacttcttcc caatatacag     2700

taagtacgtg agccagtcat ccatacacta aggcctagtt gagaaaaacc tttgattcag     2760

gatggctggg ttactaacct tgaaatgtaa gagatctggt tttgaatgta aaagttgcaa     2820

cacacaaacg gaagtcttaa aaactttttg ctctggtcag ttacaggtgg atccccaata     2880

atctgttttt ggttttctga tggaaataat agaattaggg gaaatcaaat ctggttggta     2940

ggtgtctaca gtattagaag agggtataag ggcactgttt aacactaagt tctaatactt     3000

ccagaaactg tgcattccag atctacatac taaatgctct tatcattttg aaatgggctc     3060

ttgattaata gacccatatt ttttagtggc ttctatgttg tatatttgtc taaaatgaaa     3120

gctcttttgc gttctaaaac tacaatatat gtcatcttat tttccctgag tatccaagta     3180

tagtgcagat tctatgtaaa actactaaat gacactggaa tatgtttagt agattagggg     3240

gaaaaactat aaaggtttat acaattgttt gtagttacat ttaggatgga cttatccctt     3300

tggagaagag tgaagtttgt tttttcgcca tgtgatgaag accactgtga ttttttaaaa     3360

aagtagataa tacttaaaat ggcgtaataa ttctgcactt gaatttgtac tgttaacagc     3420

acatttggaa gattttaaaa ctttttattg tcttataaat agcattcact tattattttg     3480

gatatttaag ggttccatta agttaacact gtatttggac aaagtgtgac caaattagcc     3540

agtctgtttt cttccatgtt taattagaag tgagaggtag aagtacttca aattcaacag     3600

gccagcaagc aatcggctta aaattccctt tcttaaatgt tgtgctctta tgttctcggc     3660

tttttaatga ctttattttt acagtacttg ttcagtcact tgagatgaaa tgcttggggt     3720

agcttttcca tcctcaaact taatgttttt actagttcat agtgtttgga acagtatatg     3780

ccaatcactg agactgcatc agagtttgca attttgtatg tttcattgcc aaagaaggct     3840

tagtggttgt tgactgtagt ataagtcagc tttctgtagc ataagatttg attttcccat     3900

acttacttca cttgttatac atcactgatt atttgggtta aactggactc atttcaagca     3960

gtttgctttt gttcaaatcg tgatgagaaa cctaatactg taatttgatt tgagccataa     4020

aacacatttt aatattagct tgtattatag ttattaagct tgtttttgtg gaaaaaaact     4080

tactaaaacc taggtaactc tagattaggc cagttcaggt gtattttgta tcttagtaat     4140

ggatcatatc gtaaaaatag agataagttg ggaagatata ttgattatgc tgttctgttg     4200

agggaaaggt catgtattta gaaatttaaa cttttggtta ttgtgttcac atcatagtat     4260

tcaagcatca tttatagttt ggttttgaga acttttctgg tattacgttt atggcaaatg     4320

tataaaagaa acaagttttg gttatatttt tatatttgta aagtaagttt ggttaaagtg     4380

atcactgttc tttttttatt ttattgtcat ttcaataaaa aatatttgaa agagaa         4436


<210> 685
<211> 3497
<212> DNA
<213> Homo sapiens

<400> 685
tcaaaatttc aacgatactg aatgagtccc gcggcgggtt ggctcgcgct tcgttgtcag       60

atctgaggcg aggctaggtg agccgtggga agaaaagagg gagcagctag ggcgcgggtc      120

tccctcctcc cggagtttgg aacggctgaa gttcaccttc cagcccctag cgccgttcgc      180

gccgctaggc ctggcttctg aggcggttgc ggtgctcggt cgccgcctag gcggggcagg      240

gtgcgagcag gggcttcggg ccacgcttct cttggcgaca ggattttgct gtgaagtccg      300

tccgggaaac ggaggaaaaa aagagttgcg ggaggctgtc ggctaataac ggttcttgat      360

acatatttgc cagacttcaa gatttcagaa aaggggtgaa agagaagatt gcaactttga      420

gtcagacctg taggcctgat agactgatta aaccacagaa ggtgacctgc tgagaaaagt      480

ggtacaaata ctgggaaaaa cctgctcttc tgcgttaagt gggagacaat gtcacaagtt      540

aaaagctctt attcctatga tgccccctcg gatttcatca atttttcatc cttggatgat      600

gaaggagata ctcaaaacat agattcatgg tttgaggaga aggccaattt ggagaataag      660

ttactgggga agaatggaac tggagggctt tttcagggca aaactccttt gagaaaggct      720

aatcttcagc aagctattgt cacacctttg aaaccagttg acaacactta ctacaaagag      780

gcagaaaaag aaaatcttgt ggaacaatcc attccgtcaa atgcttgttc ttccctggaa      840

gttgaggcag ccatatcaag aaaaactcca gcccagcctc agagaagatc tcttaggctt      900

tctgctcaga aggatttgga acagaaagaa aagcatcatg taaaaatgaa agccaagaga      960

tgtgccactc ctgtaatcat cgatgaaatt ctaccctcta agaaaatgaa agtttctaac     1020

aacaaaaaga agccagagga agaaggcagt gctcatcaag atactgctga aaagaatgca     1080

tcttccccag agaaagccaa gggtagacat actgtgcctt gtatgccacc tgcaaagcag     1140

aagtttctaa aaagtactga ggagcaagag ctggagaaga gtatgaaaat gcagcaagag     1200

gtggtggaga tgcggaaaaa gaatgaagaa ttcaagaaac ttgctctggc tggaataggg     1260

caacctgtga agaaatcagt gagccaggtc accaaatcag ttgacttcca cttccgcaca     1320

gatgagcgaa tcaaacaaca tcctaagaac caggaggaat ataaggaagt gaactttaca     1380

tctgaactac gaaagcatcc ttcatctcct gcccgagtga ctaagggatg taccattgtt     1440

aagcctttca acctgtccca aggaaagaaa agaacatttg atgaaacagt ttctacatat     1500

gtgccccttg cacagcaagt tgaagacttc cataaacgaa cccctaacag atatcatttg     1560

aggagcaaga aggatgatat taacctgtta ccctccaaat cttctgtgac caagatttgc     1620

agagacccac agactcctgt actgcaaacc aaacaccgtg cacgggctgt gacctgcaaa     1680

agtacagcag agctggaggc tgaggagctc gagaaattgc aacaatacaa attcaaagca     1740

cgtgaacttg atcccagaat acttgaaggt gggcccatct tgcccaagaa accacctgtg     1800

aaaccaccca ccgagcctat tggctttgat ttggaaattg agaaaagaat ccaggagcga     1860

gaatcaaaga agaaaacaga ggatgaacac tttgaatttc attccagacc ttgccctact     1920

aagattttgg aagatgttgt gggtgttcct gaaaagaagg tacttccaat caccgtcccc     1980

aagtcaccag cctttgcatt gaagaacaga attcgaatgc ccaccaaaga agatgaggaa     2040

gaggacgaac cggtagtgat aaaagctcaa cctgtgccac attatggggt gccttttaag     2100

ccccaaatcc cagaggcaag aactgtggaa atatgccctt tctcgtttga ttctcgagac     2160

aaagaacgtc agttacagaa ggagaagaaa ataaaagaac tgcagaaagg ggaggtgccc     2220

aagttcaagg cacttccctt gcctcatttt gacaccatta acctgccaga gaagaaggta     2280

aagaatgtga cccagattga acctttctgc ttggagactg acagaagagg tgctctgaag     2340

gcacagactt ggaagcacca gctggaagaa gaactgagac agcagaaaga agcagcttgt     2400

ttcaaggctc gtccaaacac cgtcatctct caggagccct ttgttcccaa gaaagagaag     2460

aaatcagttg ctgagggcct ttctggttct ctagttcagg aaccttttca gctggctact     2520

gagaagagag ccaaagagcg gcaggagctg gagaagagaa tggctgaggt agaagcccag     2580

aaagcccagc agttggagga ggccagacta caggaggaag agcagaaaaa agaggagctg     2640

gccaggctac ggagagaact ggtgcataag gcaaatccaa tacgcaagta ccagggtctg     2700

gagataaagt caagtgacca gcctctgact gtgcctgtat ctcccaaatt ctccactcga     2760

ttccactgct aaactcagct gtgagctgcg gataccgccc ggcaatggga cctgctctta     2820

acctcaaacc taggaccgtc ttgctttgtc attgggcatg gagagaaccc atttctccag     2880

acttttacct acccgtgcct gagaaagcat acttgacaac tgtggactcc agttttgttg     2940

agaattgttt tcttacatta ctaaggctaa taatgagatg taactcatga atgtctcgat     3000

tagactccat gtagttactt cctttaaacc atcagccggc cttttatatg ggtcttcact     3060

ctgactagaa tttagtctct gtgtcagcac agtgtaatct ctattgctat tgccccttac     3120

gactctcacc ctctccccac tttttttaaa aattttaacc agaaaataaa gatagttaaa     3180

tcctaagata gagattaagt catggtttaa atgaggaaca atcagtaaat cagattctgt     3240

cctcttctct gcataccgtg aatttatagt taaggatccc tttgctgtga gggtagaaaa     3300

cctcaccaac tgcaccagtg aggaagaaga ctgcgtggat tcatggggag cctcacagca     3360

gccacgcagc aggctctggg tggggctgcc gttaaggcac gttctttcct tactggtgct     3420

gataacaaca gggaaccgtg cagtgtgcat tttaagacct ggcctggaat aaatacgttt     3480

tgtctttccc tccctga                                                    3497


<210> 686
<211> 1596
<212> DNA
<213> Homo sapiens

<400> 686
agtgctccgc gcgctcttga cgtccggagc ccctggagta ggcgcttccg gccattcata       60

ctgcagtcgg tcagtgttcg gttgaaggat tctgtgtgct gtcggaccca gagggtgacg      120

gcgccgctag gatgaagctc gtgagatttt tgatgaaatt gagtcatgaa actgtaacca      180

ttgaattgaa gaacggaaca caggtccatg gaacaatcac aggtgtggat gtcagcatga      240

atacacatct taaagctgtg aaaatgaccc tgaagaacag agaacctgta cagctggaaa      300

cgctgagtat tcgaggaaat aacattcggt attttattct accagacagt ttacctctgg      360

atacactact tgtggatgtt gaacctaagg tgaaatctaa gaaaagggaa gctgttgcag      420

gaagaggcag aggaagagga agaggaagag gacgtggccg tggcagagga agagggggtc      480

ctaggcgata atgtctctca agatttcaaa gtcatatgag atttgggata ttttttgtac      540

aggttgtgtt tgtttatgtc agtttttaat aaacataaat gtgggacaga gctgtctatt      600

tagtatatca aagttttagt agtttcctcc acattcacga aattaccaca gtgagagcta      660

agcatttcta ctgggcagtt tcatttttag ttgatcaggt tttaagtttt tgaactaaaa      720

tttttctttt tctttttatg atgaataagg ttaaaataaa agccttagac aaattaaatt      780

tggcagagtt taattgagca aaggacaatt cacaaatcag gtagcccctg aaccataata      840

ggctcagagg cttcagccca gctgcatagt tgaagattta tggacagaag gaaagtgatg      900

tatggaaaat ggaagtgaga tacagcaaca gccggattag ttacagttca gcgtttgcct      960

tatttgaata tggtttgaac agttcgctgt ctttggttgg ctgaaactta gtgattgcca     1020

caagagtagg gtaccgtctg tttacacgtc cagttaggct acagttctat gtactgagaa     1080

acctttaagc tgaacttgag atatgtaaag agactttagg ctaaacttaa caatatatat     1140

aggatatata cccttctact tcacatgcac tgaatatgca ttttattgct ttactcttca     1200

ttctgtggca cctacccaca ggggaagtaa gaagtttgtt ttggtatttc ggaaactaaa     1260

gtccttatgg gatggggtct agaattgatt ctcctttcct gagttttact ccacggagtc     1320

ttaggtacct ggtaaaaagt tgtcttctaa attaagggtc attgctttgt tgtctagctg     1380

ctaatgtctt acttttgttt cttttgcttt ttaatcagtt cttaatagga tatagtttta     1440

tgttttccaa gttataactt ggagttaatg gtcactagat tatcagttat gagcagtgtt     1500

aaaatctcct attaatgtgt aatgtacctg tcagtgcctc ctttattaag gggttctttg     1560

agaataaaag agaaaagacc tactttattt gacagc                               1596


<210> 687
<211> 1316
<212> DNA
<213> Homo sapiens

<400> 687
gtacaacttc cggctgtaaa gatggcggct tcctagtgag tcggcggctg atttagaagg       60

aggttcaggc tacggtgagc cgaagccaca caggagccat ggaagtggca gagcccagca      120

gccccactga agaggaggag gaggaagagg agcactcggc agagcctcgg ccccgcactc      180

gctccaatcc tgaaggggct gaggaccggg cagtaggggc acaggccagc gtgggcagcc      240

gcagcgaggg tgagggtgag gccgccagtg ctgatgatgg gagcctcaac acttcaggag      300

ccggccctaa gtcctggcag gtgcccccgc cagcccctga ggtccaaatt cggacaccaa      360

gggtcaactg tccagagaaa gtgctccaaa accaacgccc tcaatgtctc ccagaagatg      420

attgagatgt tcgtgcggac aaaacacaag atcgacaaaa gccacgagtt tgcactggtg      480

gtggtgaacg atgacacggc ctggctgtct ggcctgacct ccgacccccg cgagctctgt      540

agctgcctct atgatctgga gacggcctcc tgttccacct tcaacatcag tggggcctca      600

cctgcccgcc agcagaaaac tgagcttccg gtcacagaga acgtgcagac gattcccccg      660

ccatatgtgg tccgcaccat ccttgtctac agccgtccac cttgccagcc ccagttctcc      720

ttgacggagc ccatgaagaa aatgttccag tgcccatatt tcttctttga cgttgtttac      780

atccacaatg gcactgagga gaaggaggag gagatgagtt ggaaggatat gtttgccttc      840

atgggcagcc tggataccaa gggtaccagc tacaagtatg aggtggcact ggctgggcca      900

gccctggagt tgcacaactg catggcgaaa ctgttggccc accccctgca gcggccttgc      960

cagagccatg cttcctacag cctgctggag gaggaggatg aagccattga ggttgaggcc     1020

actgtctgaa ccatccctgt acatctgcac cttcttgtgc aaggaagtcc ttggcctaaa     1080

gccttggttc tcaaactggg ttccttggga cctccggggt gggggggttc caggaggcac     1140

gtagggtacc ttgcagggtc ctaggaggga aacccaggat tccaggaggg atcccaggaa     1200

ctgtgggcac ccattttctg tgtctcccag cccatttcca ctcctagttt gtcatggata     1260

atttttgttc ttccctgtgt gatttttgcc atcaaaataa aaatttgaga ctcgtt         1316


<210> 688
<211> 1823
<212> DNA
<213> Homo sapiens

<400> 688
gtggagctgg ggtcactgcg cggtgggacc atggcctcgg agaagccgct ggcggcagtc       60

acttgtacag cgccggtcaa catcgcggtc atcaagtact ggggcaagcg cgatgaagag      120

ctggttctgc ccatcaactc ctccctgagc gtcactctgc accaggacca gttaaaaacc      180

accacaacag ccgtcatcag caaggacttc accgaggacc ggatttggct gaatggccgg      240

gaggaggatg tggggcagcc gcggctgcag gcctgcctgc gggagatccg ctgcctggcc      300

cggaagcgga ggaactcacg ggatggggac ccgctgccct ccagcctcag ctgcaaggtg      360

cacgtggcat cggtgaacaa cttccccacg gctgcgggcc tggcctcctc agcggcgggc      420

tatgcctgcc tagcctacac cctggcccgt gtctacggcg tggagagtga cctctcagaa      480

gtggctcgcc ggggctcagg cagcgcctgc cggagcctgt atgggggctt tgtggagtgg      540

cagatgggag agcaggccga cgggaaggac agcatcgctc ggcaagtggc ccccgagtca      600

cactggcctg aactccgcgt gctcatcctt gtggtgagcg ctgagaagaa gctgacaggc      660

agtaccgtgg gcatgcgggc cagtgtggag accagccccc tgcttcggtt ccgggccgag      720

tccgtggtgc ccgcgcgcat ggcggagatg gcccgctgca tccgggagcg agacttcccc      780

agcttcgccc agctgaccat gaaggacagc aaccagttcc acgccacctg cctcgacacc      840

ttcccgccca tctcttacct caatgccatc tcctggcgca tcatccacct ggtgcaccgc      900

ttcaacgccc accacgggga caccaaggtg gcgtacacct ttgacgcggg ccccaatgcc      960

gtgatcttca ccctggacga cactgtggct gagtttgtgg ctgctgtgtg gcacggcttt     1020

cccccaggct cgaatggaga cacgtttctg aaggggctgc aggtgaggcc ggcccctctc     1080

tcagctgagc ttcaggctgc gctggccatg gagccgaccc ccggtggggt caaatacatc     1140

attgtcactc aggtggggcc agggcctcaa atcctggatg acccctgcgc ccacctcctg     1200

ggtcctgacg gcctgccgaa gccagctgcc tgactgcctc agcagggacc gcatgccgct     1260

tggagaaggg gtggcctcgc cggagctagg gagcggatgt ggtgggctgg ccggactcct     1320

gggacatgtg ggtggtggct tgaccccggg cccatgggca gcttgctgtg gggcagtgca     1380

gggagtcctg cggccgccca ggtgtcagga gaggtccccg ccgagtgctt cagctgccct     1440

aagctgcacc agcgctttgc caagatggga tggggagggg gtatgagaac tggcagagcc     1500

tcggtgcagc agggctgaag ggctttctca ccccagctct ggctatgccc agttctctga     1560

gaaaggagct cagtggggag gtggtccctc cagcggacca gggaaggggt caccgtgctg     1620

ggagcagcct ccttgggcct caggaaacca ccaagtgcct cggatggtgg ctgcccacgg     1680

cgcttctgct gagaccctgc ccccggccca ggtgtctcgg agggtggctg cccacggcct     1740

gggtgtggct ggaatggtgg caggagtggg caccagtgcg gccccggtgg ccatggggaa     1800

taaaccagca ttgctgcctc cgg                                             1823


<210> 689
<211> 1724
<212> DNA
<213> Homo sapiens

<400> 689
gaacttttga atccgccaat cagcgccgcg cgcccccact ccgcgggtgc ggccgggcgc       60

aggccagggc tcgaaggtgg ggccgcagcg gcacggggcg gggtctgggg cccgccctcc      120

cgacacgtgg ccggggaccg ggtatataag gcccttcggg gccggccacc ctttcactac      180

ttctcccccg gactccttgg tagtctgtta gtgggagatc cttgttgccg tcccttcgcc      240

tccttcaccg ccgcagaccc cttcaagttc tagtcatgcg tgagtgcatc tccatccacg      300

ttggccaggc tggtgtccag attggcaatg cctgctggga gctctactgc ctggaacacg      360

gcatccagcc cgatggccag atgccaagtg acaagaccat tgggggagga gatgattcct      420

tcaacacctt cttcagtgaa acgggtgctg gcaagcatgt gccccgggca gtgtttgtag      480

acttggaacc cacagtcatt gatgaagttc gcactggcac ttaccgccag ctcttccacc      540

ctgagcaact catcacaggc aaggaagatg ctgccaataa ctatgcccga gggcactaca      600

ccattggcaa ggagatcatt gacctcgtgt tggaccgaat tcgcaagctg gctgaccagt      660

gcaccggtct tcagggcttc ttggttttcc acagctttgg tgggggaact ggttctgggt      720

tcacctcgct gctcatggaa cgtctctcag ttgattatgg caagaagtcc aagctggagt      780

tctccattta cccggcgccc caggtttcca cagctgtagt tgagccctac aactccatcc      840

tcaccaccca caccaccctg gagcactctg attgtgcctt catggtagac aatgaggcca      900

tctatgacat ctgtcgtaga aacctcgata tcgagcgccc aacctacact aaccttaacc      960

gccttattag ccagattgtg tcctccatca ctgcttccct gagatttgat ggagccctga     1020

atgttgacct gacagaattc cagaccaacc tggtgcccta cccccgcatc cacttccctc     1080

tggccacata tgcccctgtc atctctgctg agaaagccta ccacgaacag cttactgtag     1140

cagagatcac caatgcttgc tttgagccag ccaaccagat ggtgaaatgt gaccctcgcc     1200

atggtaaata catggcttgc tgcctgttat accgtggtga cgtggttccc aaagatgtca     1260

atgctgccat tgccaccatc aaaaccaagc gtaccatcca gtttgtggat tggtgcccca     1320

ctggcttcaa ggttggcatt aattaccagc ctcccactgt ggtgcctggc ggagacctgg     1380

ccaaggtaca gagagctgtg tgcatgctga gcaataccac agctgttgcc gaggcctggg     1440

ctcgcctgga ccacaagttt gacctgatgt atgccaagcg tgcctttgtt cactggtacg     1500

tgggtgaggg gatggaggaa ggcgagtttt cagaggcccg tgaggacatg gctgcccttg     1560

agaaggatta tgaggaggtt ggagcagata gtgctgacgg agaggatgag ggtgaagagt     1620

attaacctgt gtgctgtact tttacactcc tttgtcttgg aactgtctta tttttgttct     1680

gtaaatgtct attgccgtaa attgttaata aaattgaagt ttcc                      1724


<210> 690
<211> 2105
<212> DNA
<213> Homo sapiens

<400> 690
gttgccatta ggggactcct gaggtcctat ctccaggctg cggtgactgc actttccctg       60

gagtggaagc tgctggaagg cggaccggcc gccatgtcca cgttcaggca ggaggacgtg      120

gaggaccatt atgagatggg ggaggagctg ggcagcggcc agtttgcgat cgtgcggaag      180

tgccggcaga agggcacggg caaggagtac gcagccaagt tcatcaagaa gcgccgcctg      240

tcatccagcc ggcgtggggt gagccgggag gagatcgagc gggaggtgaa catcctgcgg      300

gagatccggc accccaacat catcaccctg cacgacatct tcgagaacaa gacggacgtg      360

gtcctcatcc tggagctggt ctctggcggg gagctctttg acttcctggc ggagaaggag      420

tcgctgacgg aggacgaggc cacccagttc ctcaagcaga tcctggacgg cgttcactac      480

ctgcactcta agcgcatcgc acactttgac ctgaagccgg aaaacatcat gctgctggac      540

aagaacgtgc ccaacccacg aatcaagctc atcgacttcg gcatcgcgca caagatcgag      600

gcggggaacg agttcaagaa catcttcggc accccggagt ttgtggcccc agagattgtg      660

aactatgagc cgctgggcct ggaggcggac atgtggagca tcggtgtcat cacctatatc      720

ctcctgagcg gtgcatcccc gttcctgggc gagaccaagc aggagacgct caccaacatc      780

tcagccgtga actacgactt cgacgaggag tacttcagca acaccagcga gctggccaag      840

gacttcattc gccggctgct cgtcaaagat cccaagcgga gaatgaccat tgcccagagc      900

ctggaacatt cctggattaa ggcgatccgg cggcggaacg tgcgtggtga ggacagcggc      960

cgcaagcccg agcggcggcg cctgaagacc acgcgtctga aggagtacac catcaagtcg     1020

cactccagct tgccgcccaa caacagctac gccgacttcg agcgcttctc caaggtgctg     1080

gaggaggcgg cggccgccga ggagggcctg cgcgagctgc agcgcagccg gcggctctgc     1140

cacgaggacg tggaggcgct ggccgccatc tacgaggaga aggaggcctg gtaccgcgag     1200

gagagcgaca gcctgggcca ggacctgcgg aggctacggc aggagctgct caagaccgag     1260

gcgctcaagc ggcaggcgca ggaggaggcc aagggcgcgc tgctggggac cagcggcctc     1320

aagcgccgct tcagccgcct ggagaaccgc tacgaggcgc tggccaagca agtagcctcc     1380

gagatgcgct tcgtgcagga cctcgtgcgc gccctggagc aggagaagct gcagggcgtg     1440

gagtgcgggc tgcgctaggc gcagtggggt gggccaggcc ccaggacagc cggagctcgg     1500

cctgcggtgg gggcgcttcc tgtggacgct gcgcctccca tcgcccgggt gcctgtcctt     1560

gcccagcgcc accaggctgg aggcggagtg ggaggagctg gagccaggcc cgtaagttcg     1620

caggcagggg tgggtgtggg acggggctgc ttctctacac agcctccacg ctggccttca     1680

ccttcacccc tgcatcgtcg gtgaccctgg gaccctccag gcagcgtggc ctgtggcacc     1740

gtgagggttg ggacccaccg aggcgcagag gcggcccgaa tgcagccctg gttcaggccc     1800

ggaggagggt ttgcgggtag ttgcacggac aattcggcgg ggtgctgcct gttgctgcca     1860

ttagcccagg aggaggtcgt gggacgggga gggtgggatg gacggcggac aggcagtccc     1920

cacgctgctg ggtggcgccg ggcttggtgg ggtcttccac tgtgtgccct tctcgccgag     1980

gccggtcccc cgggtgtggg gtgccctgct gcggactcct ccgcgagccc catcgtcgcg     2040

cctgtggacg cctaggcaag agcggccctc tgcagccaag agaaataaaa tactggcttc     2100

cagat                                                                 2105


<210> 691
<211> 1912
<212> DNA
<213> Homo sapiens

<400> 691
attttcttcc ggtggctggt ctccggcggc cccgtccccg actgggcccc gtgccccccc       60

gcccccgcgg ccccccgccg ccgggccagc cgccaccatg aagaaattct ttcaggagtt      120

caaggccgac atcaagttca agagcgcggg acccggtcag aagctcaaag agtccgtggg      180

ggaaaaggcc cacaaagaga agcccaacca gccagccccc aggccgcccc gccagggacc      240

caccaatgag gcacagatgg cagccgctgc cgccctagcc cggctggagc agaagcagtc      300

ccgggcctgg ggccccacat cgcaggacac catccgaaac caggtgagaa aggaacttca      360

agccgaagcc accgtcagcg ggagccccga ggccccaggg accaacgtgg tatctgagcc      420

cagagaggaa ggctctgccc acctggctgt gcctggcgtg tacttcacct gtccgctcac      480

tggggccacc ctgaggaagg accagcggga cgcctgcatc aaggaggcca ttctcttgca      540

cttctccacc gacccagtgg ccgcctccat catgaagatc tacacgttca acaaagacca      600

ggaccgggtg aagctgggtg tggacaccat tgccaagtac ctggacaaca tccacctgca      660

ccccgaggag gagaagtacc ggaagatcaa gctgcagaac aaggtgtttc aggagcgcat      720

taactgcctg gaagggaccc acgagttttt tgaggccatt gggttccaga aggtgttgct      780

tcccgcccag gatcaggagg accccgagga gttctacgtg ctgagcgaga ccaccttggc      840

ccagccccag agcctggaga ggcacaagga acagctgctg gctgcggagc ccgtgcgcgc      900

caagctggac aggcagcgcc gcgtcttcca gccctcgccc ctggcctcgc agttcgaact      960

gcctggggac ttcttcaacc tcacagcaga ggagatcaag cgggagcaga ggctcaggtc     1020

cgaggcggtg gagcggctga gcgtgctgcg gaccaaggcc atgcgggaga aggaggagca     1080

gcgggggctg cgcaagtaca actacacgct gctgcgcgtg cgcctccccg atggctgcct     1140

cctgcagggc actttctacg ctcgggagcg gctgggggcg gtgtacgggt tcgtccggga     1200

ggccctgcag agcgactggc tgccttttga gctgctggcc tcgggagggc agaagctgtc     1260

cgaggacgag aacctggcct tgaacgagtg cgggctggtg ccctctgccc tcctgacctt     1320

ctcgtgggac atggctgtgc tggaggacat caaggccgcg ggggccgagc cggactccat     1380

cctgaaaccc gagctcctgt cagccatcga gaagctcttg tgaaataaaa gcagggttgg     1440

cctcagccct gtgggtctgt ctcatgctct ccctgttcct ctccccgcca ccccagggcc     1500

tccaagccac ctctggaaat acttggctct gccccatggg cacgggaggg gcgccagccg     1560

tggagctgtg gaattgggcc ccgtggcaga gcccccatcc cttgggggct gtggggatgc     1620

gcccaagccc ccgagggaga ggcctgggga caccaacaaa tctaagccct ccctagctgc     1680

ttggtaactg tgtcatgaag ctgccggaca gacacacgtg gcatctccct gggcaggaga     1740

gcaggcctgc agcatgggtc ctgttcccgt gtgccgtggg tggcagtggc tgcacctggc     1800

actagggctg ctctgtggat gtgggtgaca acggcaggag gggatgctgg ccttcctgca     1860

catagacctg cagttagtaa atcataagcc caaataaaca ggttgtttga at             1912


<210> 692
<211> 2358
<212> DNA
<213> Homo sapiens

<400> 692
ccagggacag cagcccctcc agttggagga ggatcagagg gcgtggcagc ggctggagca       60

gctcatcctg ggacagctgg aggagctgaa gcagcagctg gaacagcagg aggaggagtt      120

gggtcgactg cgcctgggcg tgggggcgac ggactcagag aaaagggttc agcatctgac      180

tctggagaac gaggccctga agcagagcct gagtctcatg cgggacctcc tgctgcactg      240

gggccccggg ccccccatca gggctccgca ggaggaggca gaggcattgc tagagctcca      300

gggccggctt caggaggccc aagacaccac agaagccctc cgagcccagc tgggggtgca      360

ggaggtgcag ctgcagggcc ttcaaggggc cctccagcag ctccagcagg agacggagca      420

gaactgcagg cgtgagctac agcagatgca tgggcagctg gcaggacttc gggcacggat      480

ggccagcctg cgtcagggct gcggggacct ccgaggtttg gtcagcacct ttacccagag      540

ctgtcagggt tcgctgagtg aggcccgggg ccaggtgtcc tgggccttgg gggcactgtc      600

atctggaggg cctggcactc agctccctga ggggcagcaa gggcccccag ccggatgccc      660

agggcggctg ccagaactca agggaaatat ccgtgtgctg tgtcggctga ggccagggac      720

atcttctagc cttgtgagtg tggagcctgg cccagggggc accgtcacca cctgctaccg      780

ggggcgccat cgtcgattcc gcctagactg ggtcttccct ccagacgcca gccaggagga      840

ggtcttcaga gagctggaac ctgcggtgct gtcctgcctc cgaggctaca gcgtctgcat      900

cttcacctat ggccagacag gcaccgggaa gacctacagc atggagggcc ctcctgagga      960

ccccggcata gttcctaggg cgctgcagtc gctgttccgg gagatggggg ccggccggca     1020

gcaccgcagg taccacggcc ggtgcctgag ccctgcggag tctccagagc acccgaggcc     1080

cggccttccc ccatgtcggg ctcgctcgcc cctctaggca cgctgcacct ggtggacctg     1140

gcgggatccg aacgcgcacg gaaggcaggg gcggccggcc cgccgcgggg agacccagac     1200

ggcgcccggc gcctgcggga ggcccagacc ataaaccgct cgctgctggc gctaggaggc     1260

gtgatggccg cactgcgggc ccaccggccg cacgtgccct tccgcgactc gcagctcacg     1320

cgactgctgc agccggcgct gggcccaggc accaccgcgg tgctgctgct gcagatctcc     1380

acgcggccgg aggatctcgg ggagacagtc tgctccctca agttcgccga ccgagtgggt     1440

caagtggagc tggggccagc ccggcgccgc agggtcccgc gctcctccgg gacgccttct     1500

tccctcagca ccgacactcc gctcaccggg accccctgca cccctacgcc gtcccctggc     1560

agtcctccat gccccagtcc cgacaacggc tcgggctcgg ctctcgcgcc cgcagagggc     1620

ctgcccctct agtcctgggt cgcggccctg cccatggggt ctcaggccag gtctctgctg     1680

gcagaggcgg tagtaaagtc cctgtacccc gtctcccagg gcacaagctc cctagcctct     1740

ttggatccat tgcccctgag ctcccagagt cacccctcca cctccgcagc cagtgaagtg     1800

tgttgtgcct gctgaagtga tcaccccccg cccccagccc tgcatcaggc cacaggtctt     1860

ggctttctcc ttatcaccat ttgctgttat cacggcacac agcagggaat cccaggcccc     1920

cccgccaagt ggttacccaa gtcaccactc ctgacccaaa aatcaggcat ggcattaaaa     1980

cgttgcaaat tcctttactg ttatcccccc caccaccagg accatgtagg gtgcagtctt     2040

tactccctaa cccgtttccc gaaaaaggtg ctacctcctt tccagacaga tgagagaggg     2100

caggacttca ggctggatcc accactgggc tctccctccc ccagcctgga gcacgggagg     2160

ggaggtgacg gctggtgact gatggatggg tagtgggctg agaagagggg actaggaagg     2220

gctattccag gctcagccct gctcctgcag ctttgccgct gagtgtagga aaaacaggca     2280

tgacagacca gggtgagggt tgtgcccagc tgggccacgg ccatgcgtgg ggtggcccaa     2340

taaacaccgt ggactccc                                                   2358


<210> 693
<211> 3646
<212> DNA
<213> Homo sapiens

<400> 693
ggggctgtag ggagaggaag gagaaccccg gcgtgttgaa ggctccgcga aaccggagcg       60

gtgggggact acgcggaggg tgggagggat tccgagagga gggtcgcggg agccgtgggc      120

gctctcagcc cggtgtccgc ggtgtagggg ttggggcgcg ccgggcggcg ccgtgagaaa      180

cggcgggtct ccaggtgcgg ccgcgggcac ctgtttctag tacccccgtc cccgcgctcg      240

ccttccagcc gtgggagccg ggccgtgggg gcggccgtcg cgagcatgcg caccggcact      300

gcggcgggcg ggcgccgagt ctgggcgcgg ggacgcgggg cggcgcgaag cggggccctc      360

tgccgccccg cgctcccatg tacgcctttt actcgttgct catctacatc ttctacagcc      420

tcttccgcag ggatggtggc gccgcggcgg ccgcggagcc cggggacccc gcccagagag      480

cccgcaagcc ccggggtcgc cggcgcccag acctgcccgc gccagagctg tggaccgagc      540

tgaccggcct ggccgccagc tccgagcctg aggatgggtc ggaaggcgca gccgagggcc      600

gcgcggccgc ggtgtccctg gaagaggccc tactgcgcct cgccgagttc ctctccgtcc      660

agctgggggc ggaagagagc tgcgggggcc cggcggacct gggccagtct ggcgaggtcc      720

cctcactgtt gacagtgacc agtcagctct tggcccttct ggcatggctt cgaagcccca      780

gggggaggca ggccctgctc caggggactc agccagcccc tcgggtccgg cccccctctc      840

cagatggatc cacatcccaa gaagaaagcc cttcccactt caccgcagtc ccaggcgagc      900

cactggggga tgagacccag ggacagcagc ccctccagtt ggaggaggat cagagggcgt      960

ggcagcggct ggagcagctc atcctgggac agctggagga gctgaagcag cagctggaac     1020

agcaggagga ggagttgggt cgactgcgcc tgggcgtggg ggcgacggac tcagagaaaa     1080

gggttcagca tctgactctg gagaacgagg ccctgaagca gagcctgagt ctcatgcggg     1140

acctcctgct gcactggggc cccgggcccc ccatcagggc tccgcaggag gaggcagagg     1200

cattgctaga gctccagggc cggcttcagg aggcccaaga caccacagaa gccctccgag     1260

cccagctggg ggtgcaggag gtgcagctgc agggccttca aggggccctc cagcagctcc     1320

agcaggagac ggagcagaac tgcaggcgtg agctacagca gatgcatggg cagctggcag     1380

gacttcgggc acggatggcc agcctgcgtc agggctgcgg ggacctccga ggtttggtca     1440

gcacctttac ccagagctgt cagggttcgc tgagtgaggc ccggggccag gtgtcctggg     1500

ccttgggggc actgtcatct ggagggcctg gcactcagct ccctgagggg cagcaagggc     1560

ccccagccgg atgcccaggg cggctgccag aactcaaggg aaatatccgt gtgctgtgtc     1620

ggctgaggcc agggacatct tctagccttg tgagtgtgga gcctggccca gggggcaccg     1680

tcaccacctg ctaccggggg cgccatcgtc gattccgcct agactgggtc ttccctccag     1740

acgccagcca ggaggaggtc ttcagagagc tggaacctgc ggtgctgtcc tgcctccgag     1800

gctacagcgt ctgcatcttc acctatggcc agacaggcac cgggaagacc tacagcatgg     1860

agggccctcc tgaggacccc ggcatagttc ctagggcgct gcagtcgctg ttccgggaga     1920

tgggggccgg ccggcagcac cgggtgacac tcagcatggt ggagatctac aatgaggctg     1980

tcagggacct ccttgctcca gggcctcccg agcgcctggc cgtgaggcag ggcccagaag     2040

gccagggcgg gatccaggtg gctggcctca cccactggga cgtgcccaac ctggagacat     2100

tgcaccagat gctgaaactg gggaggagca accgggccac cgccgccacc gccatgaacc     2160

agcgcagctc ccgctcgcat gccctggtca cgctgacgct gcgcgcggcg tctccaccgc     2220

gcgctccagg caccgcaggc acgctgcacc tggtggacct ggcgggatcc gaacgcgcac     2280

ggaaggcagg ggcggccggc ccgccgcggg gagacccaga cggcgcccgg cgcctgcggg     2340

aggcccagac cataaaccgc tcgctgctgg cgctaggagg cgtgatggcc gcactgcggg     2400

cccaccggcc gcacgtgccc ttccgcgact cgcagctcac gcgactgctg cagccggcgc     2460

tgggcccagg caccaccgcg gtgctgctgc tgcaggtggg cgccggggcg gggcaggtgt     2520

gtgcgtgccg gtcgccgccc acccgggccc gcccacccgc gcctcttgcc cgcagatctc     2580

cacgcggccg gaggatctcg gggagacagt ctgctccctc aagttcgccg accgagtggg     2640

tcaagtggag ctggggccag cccggcgccg cagggtcccg cgctcctccg ggacgccttc     2700

ttccctcagc accgacactc cgctcaccgg gaccccctgc acccctacgc cgtcccctgg     2760

cagtcctcca tgccccagtc ccgacaacgg ctcgggctcg gctctcgcgc ccgcagaggg     2820

cctgcccctc tagtcctggg tcgcggccct gcccatgggg tctcaggcca ggtctctgct     2880

ggcagaggcg gtagtaaagt ccctgtaccc cgtctcccag ggcacaagct ccctagcctc     2940

tttggatcca ttgcccctga gctcccagag tcacccctcc acctccgcag ccagtgaagt     3000

gtgttgtgcc tgctgaagtg atcacccccc gcccccagcc ctgcatcagg ccacaggtct     3060

tggctttctc cttatcacca tttgctgtta tcacggcaca cagcagggaa tcccaggccc     3120

ccccgccaag tggttaccca agtcaccact cctgacccaa aaatcaggca tggcattaaa     3180

acgttgcaaa ttcctttact gttatccccc ccaccaccag gaccatgtag ggtgcagtct     3240

ttactcccta acccgtttcc cgaaaaaggt gctacctcct ttccagacag atgagagagg     3300

gcaggacttc aggctggatc caccactggg ctctccctcc cccagcctgg agcacgggag     3360

gggaggtgac ggctggtgac tgatggatgg gtagtgggct gagaagaggg gactaggaag     3420

ggctattcca ggctcagccc tgctcctgca gctttgccgc tgagtgtagg aaaaacaggc     3480

atgacagacc agggtgaggg ttgtgcccag ctgggccacg gccatgcgtg gggtggccca     3540

ataaacaccg tggactccca gcaaggctgc tgcctggtgt ttcgaggctg ctgtggtcgc     3600

agacagccgc ctcgccttgg ctccctgtca acaaggtggg ggtggg                    3646


<210> 694
<211> 987
<212> DNA
<213> Homo sapiens

<400> 694
cgccgtgcac gtcttggttc gggccgggca taaaaggctt cgcggcccag ggctcacttg       60

gcgctgagaa cgcgggtcca cgcgtgtgat cgtccgtgcg tctagccttt gcccacgcag      120

ctttcagtca tggcctccgg taacgcgcgc atcggaaagc cagcccctga cttcaaggcc      180

acagcggtgg ttgatggcgc cttcaaagag gtgaagctgt cggactacaa agggaagtac      240

gtggtcctct ttttctaccc tctggacttc acttttgtgt gccccaccga gatcatcgcg      300

ttcagcaacc gtgcagagga cttccgcaag ctgggctgtg aagtgctggg cgtctcggtg      360

gactctcagt tcacccacct ggcttggatc aacacccccc ggaaagaggg aggcttgggc      420

cccctgaaca tccccctgct tgctgacgtg accagacgct tgtctgagga ttacggcgtg      480

ctgaaaacag atgagggcat tgcctacagg ggcctcttta tcatcgatgg caagggtgtc      540

cttcgccaga tcactgttaa tgatttgcct gtgggacgct ccgtggatga ggctctgcgg      600

ctggtccagg ccttccagta cacagacgag catggggaag tttgtcccgc tggctggaag      660

cctggcagtg acacgattaa gcccaacgtg gatgacagca aggaatattt ctccaaacac      720

aattaggctg gctaacggat agtgagcttg tgcccctgcc taggtgcctg tgctgggtgt      780

ccacctgtgc ccccacctgg gtgccctatg ctgacccagg aaaggccaga cctgcccctc      840

caaactccac agtatgggac cctggagggc taggccaagg ccttctcatg cctccaccta      900

gaagctgaat agtgacgccc tcccccaagc ccacccagcc gcacacaggc ctagaggtaa      960

ccaataaagt attagggaaa ggtgtga                                          987


<210> 695
<211> 1612
<212> DNA
<213> Homo sapiens

<400> 695
gagcatcacc gcagaaacaa aggctccagc ctccggacac catgtctgtg cgcttttctt       60

ctacctccag gagacttggc tcttgcgggg gcactggctc tgtgaggctc tctagtgggg      120

gagcaggctt tggggctgga aacacatgcg gtgtgccagg cattggaagt ggcttctctt      180

gtgcttttgg gggcagctca tctgcaggag gctatggcgg aggtctgggc gggggaagtg      240

cttcctgtgc tgccttcaca gggaatgagc acggcctcct ctctggcaat gagaaggtga      300

ccatgcagaa cctcaacgac cgcttggcct cctacctgga gaatgttcga gccctagagg      360

aggccaacgc tgacttggag cagaagatca aggggtggta tgagaaattt ggacctggtt      420

cttgccgtgg ccttgatcat gattacagca gatatttccc aattattgac gaacttaaga      480

accagataat ttctgcaact accagtaatg cccatgttgt cctgcaaaat gataatgcaa      540

gactaacagc tgatgacttc agactaaagt ttgaaaacga gctagcgctt caccagagcg      600

tggaggcgga catcaatggt ttgcgaagag tcctggatga gctgaccttg tgcagaacgg      660

acctggagat ccagctggaa actctcagtg aggagctcgc ttacctcaag aagaatcatg      720

aggaggaaat gaaagctctt cagtgcgcgg ctggaggcaa cgtgaacgtg gagatgaacg      780

cggcccccgg ggtagacctc acggttctgc tgaacaatat gcgagctgag tacgaagccc      840

tcgcagagca gaaccgcagg gacgcggagg cctggttcaa cgaaaagagc gcctcgctgc      900

agcagcagat ctctgacgac gctggcgcca ccacctcagc ccggaatgag cttatcgaga      960

tgaaacgcac tcttcaaacc cttgagattg aacttcagtc cctcttagca acgaaacact     1020

ccctggagtg ctccttgaca gagaccgaga gtaactactg tgcacagctg gcacagatcc     1080

aggctcagat cggggccctg gaggagcagc tgcaccaggt cagaaccgag accgagggcc     1140

agaagctcga gtatgagcag ctccttgaca tcaaggtcca cctggaaaaa gaaattgaga     1200

cctactgcct cctgatagat ggagaagatg gctcctgttc taaatcaaaa ggctatggag     1260

gcccaggaaa tcaaacaaaa gattcatcta aaaccaccat tgtcaaaaca gttgttgaag     1320

agatagatcc tcgtggcaaa gttctctcat ccagagttca cactgtggaa gagaaatcca     1380

ccaaagtcaa caacaagaat gaacagaggg tgtcttcctg aactccagcc tctgagacag     1440

aatggccccc aaattaaaat accaaaatga agctagtttc ctaaataagg gtccccttat     1500

ttttctgctt ttcttccaat gaattaagac aagttatttt tagaatagta ccatttcttt     1560

ggctttttct ctatggtggt gtttcaataa aagttcttcc tgttgcaagt ca             1612


<210> 696
<211> 1376
<212> DNA
<213> Homo sapiens

<400> 696
tgaaaatgcc gtcggtttcg aaagcggcgg cagcggcgct gagcgggtcc cccccgcaga       60

ctgagaagcc gacccactac aggtacctga aggagttcag gacggagcag tgccccctgt      120

tttcacagca caagtgcgcg cagcaccggc cgttcacctg cttccactgg cacttcctca      180

accagcggcg ccgcaggccc ctccgcaggc gcgacggcac cttcaactac agccccgacg      240

tgtactgctc caagtacaac gaagccaccg gcgtgtgccc cgacggcgac gagtgtccct      300

acctgcaccg gacgacgggg gacacagaac gcaagtacca cctgcgttac tacaaaacag      360

gaacctgcat ccacgagaca gacgcacgtg gccactgcgt gaagaatggg ctgcactgtg      420

ccttcgcgca cggccccctg gacctgcggc cgcccgtgtg tgacgtcagg gagctgcagg      480

cccaggaagc cttgcagaac ggccagctgg gcggcgggga aggggtcccg gatctgcagc      540

ctggggtctt ggccagccag gccatgattg agaagatcct gagcgaggac ccccggtggc      600

aagatgccaa cttcgtgctg ggcagctaca agacggagca gtgcccgaag ccgccacgcc      660

tgtgccgcca gggctatgcg tgcccacact accacaatag ccgggacagg cggcgcaacc      720

cccggcggtt ccagtacagc tggcagctgg gacgccgggt ccttaggctg agtcccaggg      780

ccaacaaccc aagggtcgcc ctgcccaggg tgcacacagg accttcctcc accgcctgag      840

ccccagctgt cccctgggtc tggcttgtgg gtttggcacc tcgcagcctg cttgcctctg      900

aagccccttt ctcctccttg ctccagcccg gccttctggt tgtgcctggc ctggcttgcc      960

tcctgtctgc agtttgcacc tgagaggggg gtgggggggt gcagacccca cagggtgtct     1020

ggatgcctgg gccatggcct tggcctccct gaggccctgt ctgtgtccag ctcttccttt     1080

gagcagagag ccaccctcgc ctcttttgaa tgacctggtg ctgcctcgca tgccccggag     1140

agcacctgtg cttcctttgg gaaggacgcc ccactccttg ttgttatgcc acgttcagtc     1200

tccctctgag cagcttccga gtaaaggacc tgaacggctg tagaacaaac cacaaattag     1260

tgtctgagat tttgtcatcg cccgtcatgg aaagaaaata aaaattattt tttcaacagg     1320

cacttaatgt gtcccataaa tacaaatcag ttacaataaa gcagctagag attcca         1376


<210> 697
<211> 1271
<212> DNA
<213> Homo sapiens

<400> 697
ggcgccggcc tcggcggctg aggaaagcag gaggaggtgg cggcggcggg aagatgacgc       60

gcacctttcc ggaggatggg ggaggtaacc gaggtcctga gccggtacct gaacttgggc      120

tgctctttgg cgtaaattgc aatcgattag ggatcgtttc tcagaatcaa gttagaagtg      180

agagttcaga taagtgaggc cgccattgct gctttgaaca cctcagaagg ggagaatgga      240

tttatcagga gtgaaaaaga agagcttgct aggagtcaaa gaaaataata aaaagtccag      300

cactagggct ccttcaccta ccaaacgcaa agaccgctca gatgagaagt ccaaggatcg      360

ctcaaaagat aaaggggcca ccaaggagtc gagtgagaag gatcgcggcc gggacaaaac      420

ccgaaagagg cgcagcgctt ccagtggtag cagcagtacc aggtctcggt ccagctcgac      480

ttccagctca ggctccagca ccagcactgg ctcaagcagt ggctccagct cttcctcagc      540

atccagccgc tcaggaagct ccagcacctc ccgcagctcc agctctagca gctcttctgg      600

ctctccaagt ccttctcggc gcagacacga caacaggagg cgctcccgct ccaaatccaa      660

accacctaaa agagatgaaa aggagaggaa aaggcggagc ccatctccta agcccaccaa      720

agtgcacatt gggagactca cccggaatgt gacaaaggat cacatcatgg agatattttc      780

cacctatggg aaaattaaaa tgattgacat gcccgtggaa aggatgcatc cccatctgtc      840

caaaggctat gcgtacgtag agtttgagaa tccagatgaa gccgagaagg cgctgaagca      900

catggatgga ggacaaattg atggccagga gatcactgcc accgccgtgc tggccccctg      960

gcctaggcca ccccccagga gattcagccc tcccaggaga atgttgccac caccgcctat     1020

gtggcgcagg tctcccccac ggatgaggag aaggtcccgc tccccgaggc gcaggtcccc     1080

cgtgcgccgg agatcacggt ccccgggccg ccgccgccac aggagccgct ccagctccaa     1140

ctcctcccga taaacaggcc actgaagctc tcgcccctgt aacttatacc ccacccagct     1200

cagttttgtc acttttctag ccaaaggaag accagtagga aagcaaaccc ttgactctgg     1260

caggatttgc a                                                          1271


<210> 698
<211> 6391
<212> DNA
<213> Homo sapiens

<400> 698
acagccggtg ggctcggtgg ggctgcagaa ggtcggggct gcactgctct cggcccccac       60

acggttggtt ggttggcgtg gtaagtgccc tgatccctgg tcctgagaac tcaggctggc      120

acagggattc ccagggcatc taccaccacg cagctggagc agggctgagc ccaggagcat      180

ggagatggac gcccccaggc cccccagtct tgctgtccct ggagcagcat cgaggcccgg      240

gagaactgtg gacaacggaa ggctgagccc catccattga gttcctgggg ccccactgga      300

ggggctgctg tggccagggt gcacggtgag gaggcgagca gggtgggtgg gggcgagttc      360

ccggcctgcc ctctcttcac agctcctgga ggtgatcccc gactccatga ggaagcaaga      420

ggtgcggacg ggcagggagg ccggccaggg ccacggtacg ggctccccag ccgagcaggt      480

gaaagccctc atggatctgc tggctgggaa gggcagtcaa ggctcccagg ccccgcaggc      540

cctggatagg acaccggatg ccccgctggg gccctgcagc aatgactcaa ggatacagag      600

gcaccgcaag gccctgctga gcaaggtggg aggtggcccg gagctgggcg gaccctggca      660

caggctggcc tccctcctgc tggtggaggg cctgacggac ctgcagctga gggaacacga      720

cttcacacag gtggaggcca cccgcggggg cgggcacccc gccaggaccg tcgccctgga      780

ccggctcttc ctgcctctct cccgggtgtc tgtcccaccc cgggtctcca tcactatcgg      840

ggtggccggc atgggcaaga ccaccctggt gaggcacttc gtccgcctct gggcccatgg      900

gcaggtcggc aaggacttct cgctggtgct gcctctgacc ttccgggatc tcaacaccca      960

cgagaagctg tgtgccgacc gactcatctg ctcggtcttc ccgcacgtcg gggagcccag     1020

cctggcggtg gcagtcccag ccagggccct cctgatcctg gacggcttgg atgagtgcag     1080

gacgcctctg gacttctcca acaccgtggc ctgcacggac ccaaagaagg agatcccggt     1140

ggaccacctg atcaccaaca tcatccgtgg caacctcttt ccggaagttt ccatctggat     1200

cacctcccgt cccagtgcat ctggccagat cccagggggc ctggtggacc ggatgacgga     1260

gatccggggc tttaacgagg aggagatcaa ggtgtgtttg gagcagatgt tccccgagga     1320

ccaggccctt ctgggctgga tgctgagcca agtgcaggct gacagggccc tgtacctgat     1380

gtgcaccgtc ccagccttct gcaggctcac ggggatggcg ctaggccacc tgtggcgcag     1440

caggacgggg ccccaggatg cagagctgtg gcccccgagg accctgtgcg agctctactc     1500

atggtacttt aggatggccc tcagcgggga ggggcaggag aagggcaagg caagccctcg     1560

catcgagcag gtggcccatg gtggccgcaa gatggtgggg acattgggcc gtctggcctt     1620

ccatgggctg ctcaagaaga aatacgtgtt ttacgagcaa gacatgaagg cgtttggtgt     1680

agacctcgct ctgctgcagg gcgccccgtg cagctgcttc ctgcagagag aggagacgtt     1740

ggcatcgtca gtggcctact gcttcaccca cctgtccctg caggagtttg tggcagccgc     1800

gtattactat ggcgcatcca ggagggccat cttcgacctc ttcactgaga gcggcgtatc     1860

ctggcccagg ctgggcttcc tcacgcattt caggagcgca gcccagcggg ccatgcaggc     1920

agaggacggg aggctggacg tgttcctgcg cttcctctcc ggcctcttgt ctccgagggt     1980

caatgccctc ctggccggct ccctgctggc ccaaggcgag caccaggcct accggaccca     2040

ggtggctgag ctcctgcagg gctgcctgcg ccccgatgcc gcagtctgtg cacgggccat     2100

caacgtgttg cactgcctgc atgagctgca gcacaccgag ctggcccgca gcgtggagga     2160

ggccatggag agcggggccc tggccaggct gactggtccc gcgcaccgcg ctgccctggc     2220

ctacctcctg caggtgtccg acgcctgtgc ccaggaggcc aacctgtccc tgagcctcag     2280

ccagggcgtc cttcagagcc tgctgcccca gctgctctac tgccggaagc tcaggctgga     2340

caccaaccag ttccaggacc ccgtgatgga gctgctgggc agcgtgctga gtgggaagga     2400

ctgtcgcatt cagaagatca gcttggcgga gaaccagatc agtaacaaag gggccaaagc     2460

tctggccaga tccctcttgg tcaacagaag tctgacctct ctggacctcc gcggtaactc     2520

cattggacca caaggggcca aggcgctggc agacgctttg aagatcaacc gcaccctgac     2580

ctccctgagc ctccagggca acaccgttag ggatgatggt gccaggtcca tggctgaggc     2640

cttggcctcc aaccggaccc tctccatgct gcacctgcag aagaacagca tcgggcccat     2700

gggagcccag cggatggcag atgccttgaa gcagaacagg agtctgaaag agctcatgtt     2760

ctccagtaat agtattggtg atggaggtgc caaggccctg gctgaggccc tgaaggtgaa     2820

ccagggcctg gagagcctgg acctgcagag caattccatc agtgacgcag gagtggcagc     2880

actgatgggg gccctctgca ccaaccagac cctcctcagc ctcagccttc gagaaaactc     2940

catcagtccc gagggagccc aggccatcgc tcatgccctc tgcgccaaca gcaccctgaa     3000

gaacctggac ctgacagcca acctcctcca cgaccagggt gcccgggcca tcgcagtggc     3060

agtgagagaa aaccgcaccc tcacctccct tcacctgcag tggaacttca tccaggccgg     3120

cgctgcccag gccctgggac aagcactaca gctcaacagg agcctcacca gcttagattt     3180

acaggagaac gccatcgggg atgacggagc gtgtgcggtg gcccgtgcac tgaaggtcaa     3240

cacagccctc actgctctct atctccaggt ggcctcaatt ggtgcttcag gcgcccaggt     3300

gctaggggaa gccttggctg tgaacagaac cttggagatt ctcgacttaa gaggaaatgc     3360

cattggggtg gctggagcca aagccctggc aaatgctctg aaggtaaact caagtctccg     3420

gagactcaat cttcaagaga attctctggg gatggacggg gcgatatgca ttgccacagc     3480

actgtctgga aaccacaggc tccagcatat caatctccag ggaaaccaca ttggggactc     3540

cggggccagg atgatctcag aggccatcaa gacaaatgct cccacgtgca ctgttgaaat     3600

gtgatcctgg tggacggatc aggagaatgg gcagatgctc agctggaagc ttttgaacag     3660

aaaggccgac ttctgggggg cctgtctggg agctgggaac gctgcttgct cagcacgaga     3720

gccgggctct gcagggagga aggagaggtg ctgccggagg aggtcgtgag ctcctcttct     3780

gctgcaggag tggtccaggc agggggtgac gggtactctg ttatggcaca gagaagggag     3840

gggccacccc caagggacta ggggccaaag gcctgaaagc tgagcagtac aggaggctgg     3900

ttccagcttt acaccctgag gacttcatgt gtccccaacc tttaaaaatg tttattactg     3960

cccctttcca ctcacctggt taaaaatcat cccatgctct gagatgagct gccacctcaa     4020

gcccgtgagg agcatccgtt tggtaggggt aacagagggg acccttcttt atcttctcaa     4080

gaagaagatt tcagggtatc atccttacag acatgaaaaa gctatgggaa aattgtgaag     4140

ataaatgaaa gttttaattc taggattctg gaaacagaga cagtaagagt tctccaagga     4200

ttttgccttt tttgtttgtt tttgagatgg agtctcgctc ttgtcgccca ggctggagtg     4260

cagtggcacg atctcagctc cctgcaacct ccgcctcccg ggttcatgtg attctcctgc     4320

ctcagcctcc ccagtagctg ggaatacagg cacccgccac catgcccggc taatttttgt     4380

agttttagta gagacggggt ttcatcatgt tggccaggct ggtctcgaac tcctgacctc     4440

aggtgatcca tcagcctggg cctcccaaag tactgggatt acaggcatga gccaccacac     4500

ctggccccat tttttattta ttacaaaatc aaagacatgg gtgatgcctg gcacatgttg     4560

tctggagtct ggcacactgg ttatcaatag cacattcagt gtattcagtg atgtcattct     4620

ttatttattt ttgagacaga atctgtcacc caggctggag tgcagtggca tgatctcagc     4680

tcactgtagg ctctacctca tgggttccag tgattctcct gcctcggcct cccaagtagt     4740

tgggtctaca ggcacgcacc accacaccca gctaattttt gtatttttag tagagatggg     4800

gtttcaccat gttgatcagg ctggtcttta actcctgacc tcaagtgatc cacccacctc     4860

agcctcccaa agtgctggga ttacaggtgt gagccactgc acctggcagt gatgtcattc     4920

cttactaggc ttccaaagcc actgctgtgg ccacagcttc catggagaca ggcaagctga     4980

gcctctatgt ggcaccaatt cctgcagctg tttgtgttgg agggaaaaaa atccaaatgg     5040

acatcaacag ctttcatcaa ctaaataacc acagaaaata tttatgaaga ctataaagca     5100

atgattactt ttgaattgga aaggaatcac tattatttga aatgtttctt caaaagtgag     5160

catccggaca ggaaccatca tggatgctga ggccatggat gaaggcctac tcgggaagat     5220

gatatccttg cagtctcaaa acggcacccc acaaaggtga tatcctaatt tacaaaggga     5280

aaaaggtacc ttaatctgaa atctggcaaa tgcagcctca acagaagtga cagaattgaa     5340

catcgccaat aatgggacac acagacatca catgccccca gtctgatgca ccacggagtc     5400

gtctctgatg tattcttgtc aaaaaatgtt tgcctgattc taatcatgaa agaacaatta     5460

gaaaaaatcc aaattgacag atattctgca gaataaatgg cctgacctca tcaaaaacat     5520

caatgtcatg aaaaacacaa aacattgcag atagcgtgaa attaaagatt acagagatat     5580

aatttaatgc aagatctctg actggatcct agactgcagg aaaaagtctg ctataaagaa     5640

catttggatc acttgtagta gctgggaaat aaaacaaaac attatttgta aaagggggga     5700

aatctgaaca tgggtcttgc agtatttatg acagtttttg cggggcagag atttctagat     5760

tgacagctgt tttagtactt tcaaggtgat gctctgtctg ctggtttgca ttgtttctgt     5820

ctgagttaag agactggcag aacacagagt tgcagtagcc aaacactgga gaaagctggg     5880

ccctacagaa acctaacgct gaagaaacct caggagccaa actggtggag aaaacaaaga     5940

gtcctccctc tctccctttt caaataatga tcatacatct tcaagctgtc tgaaatggtt     6000

aaggagttca gtctgtcgtc aggcacacac cagagccagc tagcccacac agaccccatc     6060

agagcaaaac agacaagaga atttaattca tatccacata gaaaggactt ctaggtagga     6120

ggtagaccct ttagctccct tccaattaaa ggagtcccca attctggcac ctgagagtcc     6180

cctgggtcta acagctatga tatttatgta gtgtgttgct tacctaaatg aatacaattt     6240

ccttccagac acgtgacact gatattaaag tgctaatgag agggatctat ttcttcttgt     6300

acgctaaaag agaaacagca gttcagattt cccatcagaa gtccgaggac tttgttcttg     6360

ataactacta ccaataaaaa ttgagtattt g                                    6391


<210> 699
<211> 2182
<212> DNA
<213> Homo sapiens

<400> 699
gaccagagcg gttgcgggct gagcggtttc gagccggcgt cggggagcgg cggtaccggg       60

cggctgcggg gctggctcga cccagcttga ggtctcggcg tccgcgtcct gcggtgccct      120

gggatccgcc gacatgaatc ccatcgtagt ggtccacggc ggcggagccg gtcccatctc      180

caaggatcgg aaggagcgag tgcaccaggg catggtcaga gccgccaccg tgggctacgg      240

catcctccgg gagggcggga gcgccgtgga tgccgtagag ggagctgtcg tcgccctgga      300

agacgatccc gagttcaacg caggttgtgg gtctgtcttg aacacaaatg gtgaggttga      360

aatggatgct agtatcatgg atggaaaaga cctgtctgca ggagcagtgt ccgcagtcca      420

gtgtatagca aatcccatta aacttgctcg gcttgtcatg gaaaagacac ctcattgctt      480

tctgactgac caaggcgcag cgcagtttgc agcagctatg ggggttccag agattcctgg      540

agaaaaactg gtgacagaga gaaacaaaaa gcgcctggaa aaagagaagc atgaaaaagg      600

tgctcagaaa acagattgtc aaaaaaactt gggaaccgtg ggtgctgttg ccttggactg      660

caaagggaat gtagcctacg caacctccac aggcggtatc gttaataaaa tggtcggccg      720

cgttggggac tcaccgtgtc taggagctgg aggttatgcc gacaatgaca tcggagccgt      780

ctcaaccaca gggcatgggg aaagcatcct gaaggtgaac ctggctagac tcaccctgtt      840

ccacatagaa caaggaaaga cggtagaaga ggctgcggac ctatcgttgg gttatatgaa      900

gtcaagggtt aaaggtttag gtggcctcat cgtggttagc aaaacaggag actgggtggc      960

aaagtggacc tccacctcca tgccctgggc agccgccaag gacggcaagc tgcacttcgg     1020

aattgatcct gacgatacta ctatcaccga ccttccctaa gccgctggaa gattgtattc     1080

cagatgctag cttagaggtc aagtacagtc tcctcatgag acatagccta atcaattaga     1140

tctagaattg gaaaaattgt cccgtctgtc acttgttttg ttgccttaat aagcatctga     1200

atgtttggtt gtggggcggg ttctgaagcg atgagagaaa tgcccgtatt aggaggatta     1260

cttgagccca ggaggtcaaa gctgaggtga gccatgatta ctccactgca ctccagcctg     1320

ggcaacagag ccaggccctg tatcaaaaaa aaaaaaaaaa agaaaaggga aaaaagaaag     1380

aaagcagcag catgatcctg acatgacaga tgtgggagac ccacagcctg cagacactgt     1440

gggctggaag gtgggaaggg aggggccggt ggaggtggag ctgtttgaaa gtgacacagc     1500

agcagtagaa gcagtggtgg gcgaagccca ggtgaccctc agaacgttgc acaagaacat     1560

cagggaaaag aaccagaatc ctttaaggaa aatgttcttc atgtatgaga gactaaagtg     1620

atttttctaa gaaagttcag cccttctctg acttacctgg acatttctag atacttccaa     1680

aggaccctct gggaatccat agcttcctaa tctggagatg ggaggtcata agggagacgc     1740

tgtggggttc cttgaagttt cttgggttca cagaggagcc ccctcacttg gtgttctccc     1800

gtgagccagc ctccacctgc caaagacact ctggtcctcg tatagtgagt aatggggctc     1860

agggcctctc caacaacaga gaggagctga tgctgtaggg ctgaccccgt gacttcctga     1920

gtcctcaccc tgtccagtgc tttgagattc ttcccacctc cccatcctca ccagccggat     1980

cgggcgctgt gcagtgtggt cagcatggtg aagaaagtca tttcctcggt gggcagtatt     2040

cctctttatc tctcattaca ctggaaatgt tatttctgct gtatcatccg tgctcaacgt     2100

tttagtctgt caggctcacc ttctctctgg aaagaatttg cttaacttga cattccatgt     2160

gccgctaata aaatatattt tg                                              2182


<210> 700
<211> 1513
<212> DNA
<213> Homo sapiens

<400> 700
gcccgggcta cacgttaaaa acactaaggg gagcgcgcga agctgaactt ggcgctcgat       60

gggggccgtt agccgcccta gagcgcgcgg agccgcagag gcgtagctgg actacaacgc      120

agtgcatctc gggaggccaa ctcgactgga ctgggtgaga ggacagaggt ggctcgatgg      180

gcggcccgaa ggccggggat catggcggga aggcgggccc agacaggttc agccccgccc      240

cgacccgccg ctccccaccc cccggcctcg cgtgccttcc cgcagcactg ccgtccccgg      300

gatgctgagc gcccaccgtc tccccgcagc cccctcatgc ccggctgcga gctgcccgtg      360

ggcacctgcc cggacatgtg cccggccgcc gagcgcgccc agcgcgaaag ggagcaccgc      420

ctgcaccgct tggaggtggt gccgggttgc cgccaggacc cgccccgcgc ggatccgcag      480

cgcgcggtga aggagtacag ccgacccgcc gccggcaagc cccggccccc gcccagccag      540

ttgcgtccgc cctccgtgct gctggccacc gtgcgctacc tggccggtga ggtggcggag      600

agcgccgaca tcgcccgcgc cgaggtggcc agcttcgtgg cagaccgctt gcgagctgtg      660

ctcctggacc tggcgctgca gggagcgggc gacgccgagg cagctgtggt gctggaggcg      720

gcgctggcca cgctgctgac cgtagtggcg cggctcgggc ccgacgcggc gcggggaccc      780

gcggacccgg tgctgctgca ggcccaggtg caggagggct tcggctcgct gcggcgctgc      840

tacgcgcggg gcgccgggcc gcacccccgc caacccgcct tccagggcct ctttctgctc      900

tataacctgg gctcggtgga agccctgcat gaggttctac agctgcctgc tgccctgcgc      960

gcctgcccgc ccctccgcaa ggccttggcg gtagatgctg ccttccgaga gggcaatgct     1020

gcccgcctgt tccgtctgct ccagaccctg ccctacctgc caagttgcgc tgtgcagtgc     1080

catgtgggcc atgcccgccg ggaagccctg gcccgcttcg ctcgtgcctt tagcaccccc     1140

aagggccaga ccttgcctct gggcttcatg gtcaacctct tggccctgga tggactcagg     1200

gaagcacggg acctgtgcca ggcccacggg ctgcccttgg acggagagga gagagttgtg     1260

ttcctgaggg gtcgctacgt ggaggaaggg ctaccgcctg ccagtacgtg caaggtgtta     1320

gtggagagca aacttcgagg acgtaccctg gaggaggtgg tcatggcaga ggaggaagat     1380

gagggcacgg acagacctgg gtccccagcc tgaggaggga gcgtgagcct cccagagccc     1440

caggactggg ccagagcact taggtttctt tttccatggt ttccaggtaa taaaaggaac     1500

ttgttttgtt ggt                                                        1513


<210> 701
<211> 1153
<212> DNA
<213> Homo sapiens

<400> 701
cgcttcccct cggctttctt ctcgtcggtg ttcccggctg ctatagagcc gggtgagaga       60

gcgagcgccc gtcggcgggt gtcgagggcg ggttgcctcg cgctgaccct tcccgccctc      120

cttctcgtca cacaccaggt ccccgcggaa gccgcggtgt cggcgccatg gcggagctga      180

cggctcttga gagtctcatc gagatgggct tccccagggg acgcgcggag aaggctctgg      240

ccctcacagg gaaccagggc atcgaggctg cgatggactg gctgatggag cacgaagacg      300

accccgatgt ggacgagcct ttagagactc cccttggaca tatcctggga cgggagccca      360

cttcctcaga gcaaggcggc cttgaaggat ctggttctgc tgccggagaa ggcaaacccg      420

ctttgagtga agaggaaaga caggaacaaa ctaagaggat gttggagctg gtggcccaga      480

agcagcggga gcgtgaagaa agagaggaac gggaggcatt ggaacgggaa cggcagcgca      540

ggagacaagg gcaagagttg tcagcagcac gacagcggct acaggaagat gagatgcgcc      600

gggctgctga ggagaggcgg agggaaaagg ccgaggagtt agcagccaga caaagagtta      660

gagaaaagat cgagagggac aaagcagaga gagccaagaa gtatggtggc agtgtgggct      720

ctcagccacc cccagtggca ccagagccag gtcctgttcc ctcttctccc agccaggagc      780

ctcccaccaa gcgggagtat gaccagtgtc gcatacaggt caggctgcca gatgggacct      840

cactgaccca gacgttccgg gcccgggaac agctggcagc tgtgaggctc tatgtggagc      900

tccaccgtgg ggaggaacta ggtgggggcc aggaccctgt gcaattgctc agtggcttcc      960

ccagacgggc cttctcagaa gctgacatgg agcggcctct gcaggagctg ggactcgtgc     1020

cttctgctgt tctcattgtg gccaagaaat gtcccagctg agggcctttg tcccattgtc     1080

cctctgtgac cccttcatct ttgataaagc actgacatct ccttcctaat aaatagaccc     1140

tgagttctgt aca                                                        1153


<210> 702
<211> 825
<212> DNA
<213> Homo sapiens

<400> 702
cacacacaca tctgcacctc aaccacagac tacacttgct gaactggctc ctggggccat       60

gaggctgtca ctgccactgc tgctgctgct gctgggagcc tgggccatcc cagggggcct      120

cggggacagg gcgccactca cagccacagc cccacaactg gatgatgagg agatgtactc      180

agcccacatg cccgctcacc tgcgctgtga tgcctgcaga gctgtggctt accagatgtg      240

gcaaaatctg gcaaaggcag agaccaaact tcatacctca aactctgggg ggcggcggga      300

gctgagcgag ttggtctaca cggatgtcct ggaccggagc tgctcccgga actggcagga      360

ctacggagtt cgagaagtgg accaagtgaa acgtctcaca ggcccaggac ttagcgaggg      420

gccagagcca agcatcagcg tgatggtcac agggggcccc tggcctacca ggctctccag      480

gacatgtttg cactacttgg gggagtttgg agaagaccag atctatgaag cccaccaaca      540

aggccgaggg gctctggagg cattgctatg tgggggaccc cagggggcct gctcagagaa      600

ggtgtcagcc acaagagaag agctctagtc ctggactcta ccctcctctg aaagaagctg      660

gggcttgctc tgacggtctc cactcccgtc tgcaggcagc caggagggca ggaagccctt      720

gctctgtgct gccatcctgc ctccctcctc cagcctcagg gcactcgggc ctgggtggga      780

gtcaacgcct tcccctctgg actcaaataa aacccagtga cctca                      825


<210> 703
<211> 3282
<212> DNA
<213> Homo sapiens

<400> 703
ctggtctgcg gctgagatac acagagcgac agagacattt attgttattt gttttttggt       60

ggcaaaaagg gaaaatggcg aacgactccc ctgcaaaaag tctggtggac atcgacctct      120

cctccctgcg ggatcctgct gggatttttg agctggtgga agtggttgga aatggcacct      180

atggacaagt ctataagggt cgacatgtta aaacgggtca gttggcagcc atcaaagtta      240

tggatgtcac tgaggatgaa gaggaagaaa tcaaactgga gataaatatg ctaaagaaat      300

actctcatca cagaaacatt gcaacatatt atggtgcttt catcaaaaag agccctccag      360

gacatgatga ccaactctgg cttgttatgg agttctgtgg ggctgggtcc attacagacc      420

ttgtgaagaa caccaaaggg aacacactca aagaagactg gatcgcttac atctccagag      480

aaatcctgag gggactggca catcttcaca ttcatcatgt gattcaccgg gatatcaagg      540

gccagaatgt gttgctgact gagaatgcag aggtgaaact tgatgaaact gagtatgagt      600

acagtgggag tgaggaagaa gaggaggaag tgcctgaaca ggaaggagag ccaagttcca      660

ttgtgaacgt gcctggtgag tctactcttc gccgagattt cctgagactg cagcaggaga      720

acaaggaacg ttccgaggct cttcggagac aacagttact acaggagcaa cagctccggg      780

agcaggaaga atataaaagg caactgctgg cagagagaca gaagcggatt gagcagcaga      840

aagaacagag gcgacggcta gaagagcaac aaaggagaga gcgggaagct agaaggcagc      900

aggaacgtga acagcgaagg agagaacaag aagaaaagag gcgtctagag gagttggaga      960

gaaggcgcaa agaagaagag gagaggagac gggcagaaga agaaaagagg agagttgaaa     1020

gagaacagga gtatatcagg cgacagctag aagaggagca gcggcacttg gaagtccttc     1080

agcagcagct gctccaggag caggccatgt tactggagtg ccgatggcgg gagatggagg     1140

agcaccggca ggcagagagg ctccagaggc agttgcaaca agaacaagca tatctcctgt     1200

ctctacagca tgaccatagg aggccgcacc cgcagcactc gcagcagccg ccaccaccgc     1260

agcaggaaag gagcaagcca agcttccatg ctcccgagcc caaagcccac tacgagcctg     1320

ctgaccgagc gcgagaggtt cctgtgagaa caacatctcg ctcccctgtt ctgtcccgtc     1380

gagattcccc actgcagggc agtgggcagc agaatagcca ggcaggacag agaaactcca     1440

ccagcagtat tgagcccagg cttctgtggg agagagtgga gaagctggtg cccagacctg     1500

gcagtggcag ctcctcaggg tccagcaact caggatccca gcccgggtct caccctgggt     1560

ctcagagtgg ctccggggaa cgcttcagag tgagatcatc atccaagtct gaaggctctc     1620

catctcagcg cctggaaaat gcagtgaaaa aacctgaaga taaaaaggaa gttttcagac     1680

ccctcaagcc tgctgtaagg attgatctga ccgcactggc caaagagctt cgagcagtgg     1740

aagatgtacg gccacctcac aaagtaacgg actactcctc atccagtgag gagtcgggga     1800

cgacggatga ggaggacgac gatgtggagc aggaaggggc tgacgagtcc acctcaggac     1860

cagaggacac cagagcagcg tcatctctga atttgagcaa tggtgaaacg gaatctgtga     1920

aaaccatgat tgtccatgat gatgtagaaa gtgagccggc catgacccca tccaaggagg     1980

gcactctaat cgtccgccag actcagtccg ctagtagcac actccagaaa cacaaatctt     2040

cctcctcctt tacacctttt atagacccca gattactaca gatttctcca tctagcggaa     2100

caacagtgac atctgtggtg ggattttcct gtgatgggat gagaccagaa gccataaggc     2160

aagatcctac ccggaaaggc tcagtggtca atgtgaatcc taccaacact aggccacaga     2220

gtgacacccc ggagattcgt aaatacaaga agaggtttaa ctctgagatt ctgtgtgctg     2280

ccttatgggg agtgaatttg ctagtgggta cagagagtgg cctgatgctg ctggacagaa     2340

gtggccaagg gaaggtctat cctcttatca accgaagacg atttcaacaa atggacgtac     2400

ttgagggctt gaatgtcttg gtgacaatat ctggcaaaaa ggataagtta cgtgtctact     2460

atttgtcctg gttaagaaat aaaatacttc acaatgatcc agaagttgag aagaagcagg     2520

gatggacaac cgtaggggat ttggaaggat gtgtacatta taaagttgta aaatatgaaa     2580

gaatcaaatt tctggtgatt gctttgaaga gttctgtgga agtctatgcg tgggcaccaa     2640

agccatatca caaatttatg gcctttaagt catttggaga attggtacat aagccattac     2700

tggtggatct cactgttgag gaaggccaga ggttgaaagt gatctatgga tcctgtgctg     2760

gattccatgc tgttgatgtg gattcaggat cagtctatga catttatcta ccaacacata     2820

tccagtgtag catcaaaccc catgcaatca tcatcctccc caatacagat ggaatggagc     2880

ttctggtgtg ctatgaagat gagggggttt atgtaaacac atatggaagg atcaccaagg     2940

atgtagttct acagtgggga gagatgccta catcagtagc atatattcga tccaatcaga     3000

caatgggctg gggagagaag gccatagaga tccgatctgt ggaaactggt cacttggatg     3060

gtgtgttcat gcacaaaagg gctcaaagac taaaattctt gtgtgaacgc aatgacaagg     3120

tgttctttgc ctctgttcgg tctggtggca gcagtcaggt ttatttcatg accttaggca     3180

ggacttctct tctgagctgg tagaagcagt gtgatccagg gattactggc ctccagagtc     3240

ttcaagatcc tgagaacttg gaattccttg taactggagc tc                        3282


<210> 704
<211> 2901
<212> DNA
<213> Homo sapiens

<400> 704
tggcgaggtt agggcccgcg ttgcgacgtg gtgcagcgca tattttcaca agtgggtctc       60

ccttgtccgg gactatggcc accgactcgt gggccctggc ggtggacgag caggaagcgg      120

ctgtcaagtc gatgaccaat ttgcagatca aggaagagaa agtcaaagca gataccaatg      180

gtattatcaa aaccagtacc actgccgaga aaacagatga agaggagaaa gaggacagag      240

ctgcccagtc cttactcaac aagctgatca gaagcaacct tgttgataac acaaaccaag      300

tggaagtcct gcaacgggat ccaaactccc ctctgtactc ggtgaagtcg tttgaagagc      360

ttcggctgaa accacagctt ctccagggag tctatgccat gggcttcaat cgaccctcca      420

agatacaaga gaacgcatta cccatgatgc ttgctgaacc cccacagaat ctgattgccc      480

agtctcagtc tggcactggt aaaacagctg cctttgtctt agccatgctc agccgagtgg      540

agccatcaga cagatacccc cagtgtctgt gcctctcccc aacatatgag ctggcgcttc      600

aaacaggaaa agtgattgag cagatgggca aattttaccc agaactgaag cttgcctatg      660

ccgttcgagg caataaattg gaaagaggcc agaagatcag tgagcagatt gtcattggca      720

cccctgggac cgtgctggac tggtgctcca agctcaagtt cattgatccc aagaaaatca      780

aggtgtttgt tctggatgag gctgatgtca tgatagccac tcagggccac caagatcaga      840

gcatccgcat ccagaggatg ctgcccagga actgccagat gctgcttttc tccgccacct      900

ttgaagactc tgtgtggaag tttgcccaga aagtggtccc agacccaaat gttatcaaac      960

tgaagcgtga ggaagagacc ctggatacca tcaagcagta ctatgtcctg tgcagcagca     1020

gagacgagaa gttccaggcc ttgtgtaacc tctacggggc catcaccatt gctcaagcca     1080

tgatcttctg ccatactcgc aaaacagcta gttggctggc agcagagctc tcaaaagaag     1140

gccaccaggt ggctctgctg agtggggaga tgatggtgga gcagagggct gcggtgattg     1200

agcgcttccg agagggcaaa gagaaggttt tggtgaccac caacgtgtgt gcccgcggca     1260

ttgatgttga acaagtgtct gtcgtcatca actttgatct tcccgtggac aaggacggga     1320

atcctgacaa tgagacctac ctgcaccgga tcgggcgcac gggccgcttt ggcaagaggg     1380

gcctggcagt gaacatggtg gacagcaagc acagcatgaa catcctgaac agaatccagg     1440

agcattttaa taagaagata gaaagattgg acacagatga tttggacgag attgagaaaa     1500

tagccaactg agaagctcca ccagccactg atgccagccc tggcactgcc cctgcacagg     1560

agacaagtgc atttagggca caggccccga catcacccca aggacaacgg cagaagtaga     1620

gagaaactac ctacctcact tcaaattatg tttggacttg acaaaaatag gtgcaaatga     1680

tggggggcaa tagaagaaaa aatttgcatt ttggaaaatt gggtcctttc cccacttttt     1740

taaagccaca ttcccccatc tttataataa tctggtcaca gtggtagtcg ctggccccag     1800

gaccccctcc tgattttggc taggcatcgt ggaaccagct ccagcccctg aagaaacgat     1860

agatgtgcag gttgtgcgga agaggctgag tggaaaatgg tgtgagcccc accgctgtgc     1920

atcgaatgag ggaagtggca gcagagaggc cagagctgcc ccctctctgt ctcttcaatg     1980

gacccttcac aagtgtttct cctgcccttg gggctgtctt ccttctcctg aaatccagag     2040

actttcttgc tcatcccttc tccctttcac ttctgttctc tgctgcagaa agcagacttg     2100

catatccctg atgagcagct cggctacttt tgtaaacttc agatttggag agaaacacga     2160

aagtctgaat cctgacccct tgagagagag tgatctggcg agggccgatg aaggggctgg     2220

gcctggtctt gccttctctt ctctcggttg ctccctctgc ctaggcccct ggtactcagt     2280

cacggcagcc aggagacccc aggtgagttt ctgagcgcat acgtagttgg ttcttacccc     2340

caggtgtcac acggggccga gagctgagca agaatttgga atggaagtta tgaccaaggg     2400

aattatgctg ttcatttata atagtggaca ttatggagag ctctgattcc tacataatat     2460

gaataaggat ggataggccg ggcgtggtgg ctcatgccta taatcccagc acgttgggag     2520

gctgaggcgg gcggatcggt tgagctcagg cgttcgggac cagcctggcc aacatgatga     2580

aaccccgtct ctaccaaaaa tagaaaaaaa tatagccggg cctggtggcg cacgcctgta     2640

gtcccagcta ctcgggaggc tgaggtagga ggatcgcttg agcctgggta gaggctgctg     2700

tgagctgaaa tggcgccact gcactccagc ctgggtaaca gagcgagacc ccgactcaat     2760

aaataaataa ggatggataa attgtagcgt atgcaccatt cattatgcta agacatttta     2820

aagtaattat gagaaacgct ctactaatga tttgttttta tttgtatttt tctgcttatt     2880

agacaaatat atactcattt t                                               2901


<210> 705
<211> 2995
<212> DNA
<213> Homo sapiens

<400> 705
agaatgatga tgtcgcacgc tgggtgggaa ctgacgtcac ctgtgctcac cgccgcttcc       60

ggtccgcgtg aggtgcattc tcgcgccggt ggcgaggtta gggcccgcgt tgcgacgtgg      120

tgcagcgcat attttcacaa gtgggtctcc cttgtccggg actatggcca ccgactcgtg      180

ggccctggcg gtggacgagc aggaagcggc tgtcaagtcg atgaccaatt tgcagatcaa      240

ggaagagaaa gtcaaagcag ataccaatgg tattatcaaa accagtacca ctgccgagaa      300

aacagatgaa gaggagaaag aggacagagc tgcccagtcc ttactcaaca agctgatcag      360

aagcaacctt gttgataaca caaaccaagt ggaagtcctg caacgggatc caaactcccc      420

tctgtactcg gtgaagtcgt ttgaagagct tcggctgaaa ccacagcttc tccagggagt      480

ctatgccatg ggcttcaatc gaccctccaa gatacaagag aacgcattac ccatgatgct      540

tgctgaaccc ccacagaatc tgattgccca gtctcagtct ggcactggta aaacagctgc      600

ctttgtctta gccatgctca gccgagtgga gccatcagac agataccccc agtgtctgtg      660

cctctcccca acatatgagc tggcgcttca aacaggaaaa gtgattgagc agatgggcaa      720

attttaccca gaactgaagc ttgcctatgc cgttcgaggc aataaattgg aaagaggcca      780

gaagatcagt gagcagattg tcattggcac ccctgggacc gtgctggact ggtgctccaa      840

gctcaagttc attgatccca agaaaatcaa ggtgtttgtt ctggatgagg ctgatgtcat      900

gatagccact cagggccacc aagatcagag catccgcatc cagaggatgc tgcccaggaa      960

ctgccagatg ctgcttttct ccgccacctt tgaagactct gtgtggaagt ttgcccagaa     1020

agtggtccca gacccaaatg ttatcaaact gaagcgtgag gaagagaccc tggataccat     1080

caagcagtac tatgtcctgt gcagcagcag agacgagaag ttccaggcct tgtgtaacct     1140

ctacggggcc atcaccattg ctcaagccat gatcttctgc catactcgca aaacagctag     1200

ttggctggca gcagagctct caaaagaagg ccaccaggtg gctctgctga gtggggagat     1260

gatggtggag cagagggctg cggtgattga gcgcttccga gagggcaaag agaaggtttt     1320

ggtgaccacc aacgtgtgtg cccgcggcat tgatgttgaa caagtgtctg tcgtcatcaa     1380

ctttgatctt cccgtggaca aggacgggaa tcctgacaat gagacctacc tgcaccggat     1440

cgggcgcacg ggccgctttg gcaagagggg cctggcagtg aacatggtgg acagcaagca     1500

cagcatgaac atcctgaaca gaatccagga gcattttaat aagaagatag aaagattgga     1560

cacagatgat ttggacgaga ttgagaaaat agccaactga gaagctccac cagccactga     1620

tgccagccct ggcactgccc ctgcacagga gacaagtgca tttagggcac aggccccgac     1680

atcaccccaa ggacaacggc agaagtagag agaaactacc tacctcactt caaattatgt     1740

ttggacttga caaaaatagg tgcaaatgat ggggggcaat agaagaaaaa atttgcattt     1800

tggaaaattg ggtcctttcc ccactttttt aaagccacat tcccccatct ttataataat     1860

ctggtcacag tggtagtcgc tggccccagg accccctcct gattttggct aggcatcgtg     1920

gaaccagctc cagcccctga agaaacgata gatgtgcagg ttgtgcggaa gaggctgagt     1980

ggaaaatggt gtgagcccca ccgctgtgca tcgaatgagg gaagtggcag cagagaggcc     2040

agagctgccc cctctctgtc tcttcaatgg acccttcaca agtgtttctc ctgcccttgg     2100

ggctgtcttc cttctcctga aatccagaga ctttcttgct catcccttct ccctttcact     2160

tctgttctct gctgcagaaa gcagacttgc atatccctga tgagcagctc ggctactttt     2220

gtaaacttca gatttggaga gaaacacgaa agtctgaatc ctgacccctt gagagagagt     2280

gatctggcga gggccgatga aggggctggg cctggtcttg ccttctcttc tctcggttgc     2340

tccctctgcc taggcccctg gtactcagtc acggcagcca ggagacccca ggtgagtttc     2400

tgagcgcata cgtagttggt tcttaccccc aggtgtcaca cggggccgag agctgagcaa     2460

gaatttggaa tggaagttat gaccaaggga attatgctgt tcatttataa tagtggacat     2520

tatggagagc tctgattcct acataatatg aataaggatg gataggccgg gcgtggtggc     2580

tcatgcctat aatcccagca cgttgggagg ctgaggcggg cggatcggtt gagctcaggc     2640

gttcgggacc agcctggcca acatgatgaa accccgtctc taccaaaaat agaaaaaaat     2700

atagccgggc ctggtggcgc acgcctgtag tcccagctac tcgggaggct gaggtaggag     2760

gatcgcttga gcctgggtag aggctgctgt gagctgaaat ggcgccactg cactccagcc     2820

tgggtaacag agcgagaccc cgactcaata aataaataag gatggataaa ttgtagcgta     2880

tgcaccattc attatgctaa gacattttaa agtaattatg agaaacgctc tactaatgat     2940

ttgtttttat ttgtattttt ctgcttatta gacaaatata tactcatttt aaaaa          2995


<210> 706
<211> 4533
<212> DNA
<213> Homo sapiens

<400> 706
aatgaggacg cgtggacgcg cggcacgccg gtcctggcta caggcgcggc gtttgaagaa       60

aaactgtcac tgaagagtca tggtggggcc cgggcctacc gctgctgccg ctgtcgaaga      120

gcggcagaga aagcttcagg agtaccttgc agccaaggga aaactgaaga gccaaaacac      180

caagccttat ctaaaatcca agaataattg ccagaatcaa ccaccttcta aatctactat      240

tagacccaaa aatgatgtta ccaaccatgt tgttttgcct gtcaaaccta aaaggtccat      300

cagcattaaa ctccagccca gaccacctaa tactgcaggg tcccagaagc cgaagttgga      360

gccaccaaaa cttctgggca aaaggctgac ttcagaatgt gtttcttcta acccatactc      420

taagccttct agcaagagtt ttcaacagtg tgaagctgga tcgtccacaa caggagaact      480

gtcaagaaaa cctgtggggt cacttaatat agagcaattg aaaactacaa agcagcagtt      540

aacagatcaa ggaaatggta aatgtataga ctttatgaat aatatccatg ttgaaaacga      600

atctttggat aactttctaa aagaaacaaa caaagagaac ttgctcgata tcttaacaga      660

acctgagagg aagccagatc ctaaattata taccagaagt aagccaaaga ctgactctta      720

taatcaaacc aagaacagtt tagttcctaa acaagccttg ggcaaaagtt cagttaatag      780

tgctgttctg aaagataggg ttaataaaca atttgttgga gaaacacaaa gcaggacttt      840

cccagtaaaa tcacagcaac tctctagagg agcagatctt gcaagaccag gagtaaaacc      900

ctcaaggacg gttccctctc actttattcg gacccttagt aaagttcagt catcaaagaa      960

accagtagtc aagaacatca aagatataaa ggttaatagg agtcaatatg aaagaccaaa     1020

tgaaactaag atacggtcat accctgttac tgaacagaga gtgaagcaca ccaaacccag     1080

aacatacccc agtttgcttc agggtgaata taacaacaga catccaaaca tcaagcaaga     1140

tcagaagtcc agccaagttt gtatacctca gacatcatgt gtactgcaaa agtcaaaagc     1200

cataagccag aggcctaatt tgacagttgg cagatttaat tcagccattc caagcacccc     1260

tagcataaga ccaaatggaa ccagtggtaa taaacataac aataatggct ttcagcaaaa     1320

agcacagact ttggactcca agttgaaaaa ggctgttccc cagaaccatt ttctgaacaa     1380

gacagctccc aaaactcaag ctgatgtcac aaccgtaaat gggacccaaa caaacccaaa     1440

tattaaaaag aaggcaacag cagaggatcg aaggaaacaa ctagaagaat ggcagaaatc     1500

taagggaaaa acctataaac ggcctcctat ggaacttaaa acaaaaagaa aagtaataaa     1560

ggaaatgaat atttcattct ggaagagcat tgaaaaagaa gaggaagaaa agaaagcaca     1620

actcgaactg tccagtaaaa ttaacaacac tctgacagaa tgtctgaacc tcatcgaagg     1680

gggtgtacct tctaatgaaa tacttaacat attgtccagc attcctgaag ctgaaaaatt     1740

tgctaaattc tggatctgca aagcaaagtt gttggcaagt aaaggcacct ttgatgttat     1800

tgggctatat gaagaggcca ttaaaaatgg ggcaacacca atacaagagt tgcggaaagt     1860

tgttcttaat atcttgcaag actcaaacag aaccacagaa gggattactt ctgactcttt     1920

agttgctgaa actagtataa catcagtgga agagctggcc aagaagatgg aatctgtgaa     1980

gtcttgtctt tctccaaaag agagggaaca agtcacggcg acaccccgaa tagccaaggc     2040

agaacagcat aattatcctg gtatcaaatt acagattggt ccaatcccta gaataaatgg     2100

gatgccggaa gtgcaagaca tgaaatttat cactcctgta cggcgttcgt cgaggattga     2160

gcgagcagtg tcccgctacc cagaaatgct gcaggaacac gatttagtag tggcttctct     2220

tgatgaactg ttagaagtgg aagaaacaaa atgttttata ttccgtagaa atgaggcgct     2280

gcctgtaaca ttggggtttc aaacccctga atcataattt cttgatgctt tttttaaaaa     2340

aggtgtttca gaaccaacat aagacaagaa atattcttgt ccaagtgacc tggaaaaaaa     2400

gagaggcatc atggatgcag attatggacg ctcaggactt aagtaattca ctgggcttac     2460

tctcaaattt tctctcccca tgggaaaatc tttgctttat gtgtttaaga ccagtttgcc     2520

agttttacag tatacataaa tttcaaactt ttgaatattt accctacaac tatgataaat     2580

atttatactt tattgatcta ctttaatccc aacatagttt tttatatcag aaggttggtc     2640

ccacaatata atgggacttt tctttctgca tccaccttag cagagggcaa gttctttcat     2700

cgtggaagat ctgaactttg acgctagctt gacaggctga atggaccttg acagatggcc     2760

aagtcaaaac ccctcatttt acagatgagt ttatgctagc tgtgcctttg ctcagagatc     2820

ataaatttat gtgtgatctt tgactttcat cacagtatcc ttgtaaatga gagagaattc     2880

ttgttttttc tatgccaggt ctcctcagat gaaacacaat cctgaattgg catggtcgtc     2940

tagcttttat attcaaacct agttttgcat ttgttactca gaaacacttc aagtaacaaa     3000

aggggggcag gggagagggg tggggagtgg acacttgctt cttcagttct ttgctcagct     3060

agggtatagc tggcctgaga aggcagtgca agccccagag actgttgtag gttgcttttt     3120

cttcctcctg ggcaactatt tgtggaaagg ttttacctta gtcattatgt aaatataatt     3180

gtgtagaaaa acctagtcaa cacattttaa attttagctt tcttaatatt taagtattat     3240

cttaaaacaa cattaaattt ctattagttc ctgcttgttt atcttattta ttatagaaaa     3300

ccatgataat ggctttgcat agagaattag gagtttgtct aaggatatac cagttggctg     3360

tcctaagaaa caaggagcat tcattaccaa ggagaatgga ctttgatcaa aggtctatca     3420

gcctcatcca ggaactagat ttttttaagg gaagcagatc tatttctgaa agtcagattt     3480

ataataaagc tcaaaaaact gagctataaa cctgtaatac cagcagactt tcaataagag     3540

actcttacaa ctcaattgtg gaaaaactaa taattaaaaa tgggcaaagg acctgagcag     3600

acatttctcc aaagaagaca taagaaatgg ccagtaggta tagatatgaa aaggtgttca     3660

gcatcattaa tcataagaat aatgtaaatt aaaaccactg tgagctatca cctcacatct     3720

ataagaatgg ctattaacaa gacatgagat aaatgttgat gagattgtgg agaaaagaga     3780

accctagtac actgtttgtg ggcgtgtaga ctggggcagc cgttatggaa aacggtatgg     3840

aggctcctaa agaaattaaa aatagaactg ttatctgacc ctcttctgag taagtatgta     3900

cccaaagaag atgaaatcac cagctgggcg cagtgactca cacctgtaat cccagcactt     3960

tggagtgggt gaatcacctg aggtcaggag ttcaagacca gcttgaccaa catggtgaaa     4020

ccccgtctct actaaaaata caaaaagtag gcgggcatgg tgacgggcac ctgtaatccc     4080

agctacttgg gaggctgagg cagaagaatc acttgaactc gggaggtgga ggttgcagtg     4140

agccaaaatt gcgtcactgc actccagcct gggttacaga gcaagactcc atctcaaaaa     4200

aaaaaaagat gaaatcatca cctcataaag atatctgcac tcacatgttt gtggcagtgt     4260

tattctcaat agccaagatg tggaaacaac ctaaatgccc atcaatggac aaataaagaa     4320

aatacggcat atgcatgccg tggaatagta ttcatccttg gaaaagaggg agttcttgcc     4380

atttgccaca acatagatgg acctggagaa cattatgcta agtgaaataa gccagaccca     4440

aggaaaaata ctgcatgatc tcacatatgg aatatttaat tttttaagaa agagctcaag     4500

tacacagaga aagtgcttac cacagattgg gga                                  4533


<210> 707
<211> 1667
<212> DNA
<213> Homo sapiens

<400> 707
gagcgacgcg tacgtctacc tgcctgcctt acagggcacc taggagggac cccttcctgg       60

cccatccgcg ccgcgcaggc gcacgcccac gcagcgccta gacgcccgag ccgagcgtcc      120

cgtctcctag taaccagccg ctagccccct tttccacgac tcatttctta atctctgcct      180

gaggctgccg cacctggatg gaacgcgcat gcgcaaggct gtctctcgca gccccgcctt      240

ccctcagctt gaaacacctg ctgcttcgcg gcggtggctt tgtgccactt ttcccagggc      300

ttgggcatca ttctggaccc atgttcggtg aaccggttac tctcagagct gctttcgggc      360

gcagctcctg ctgcagccag ggcccgtttt aagagaggct tccaggtcca gccctcccgc      420

tgcagcctgc agggagcgag ccggcctgtc ccgatgacat agacactagg tttttacagc      480

aattctctga tgaccttgat atggtagaac gctgtgtatt tcaagagtaa gctctcgttt      540

gaggagacta acaattcctg ttttcgccag atttcttctt gaatggcaac ctaaatgcca      600

gtccaaagag gcccccaata gacttgttca cccttcatgt cctcaactct ggggaagtta      660

agtaatcaag ttgaagaaac acttccacta cttaaaaagg tacctgcaaa ttactttcac      720

atttgttcag ctatcctaat gggattttca cttagtaaat ctgctactca ggtatctgct      780

atacatatgg attcaaaagt ggatgatcac ttaatacgag ggactgaaaa aagcaggttg      840

gaaccagcga ctcagttatt tcaaaacacc aagaaaataa gattagaaga cacaaatcaa      900

gaaaacttta caaggattga agggactggc acaggatctc tttctgggaa agccttgggt      960

tcagtggtat atgtcaaaga aagtgatgga ctagaaatga cagatgtgga atgaagcaat     1020

ttgtacgtat taccaaagaa accaaaaact gcctttgact aaggggggtg ttgaaagaga     1080

acttaacctt attaggaaac cctgacaaaa tgatggaaga ctattgcctt attttgcact     1140

atttgtgaat catcttacac tgcatttttt tatgatgctt attcaaaagg cagttgcttt     1200

agggtgaaaa agccttccaa gattcaaagc agatttctct ggtattatat tatatccttc     1260

ttaaaaacca gagtttttaa gtaacagtat ttgaatggca tcaaaacatt ttcattttaa     1320

tgtatttctt taacaagtgg ttaaaaaaag tgtccaagca gccgggcgca gtggctcaca     1380

cctgtaatcc cagcactttg ggaggccaag gcgggtcaat cacctgaggt caggagttcg     1440

caaccagcct ggccaatatg gtgagacccc atctctacta aaaatgcaaa aagttagcca     1500

ggcatggtgg tgggcacctg tgatcccagc tacctgggag gctgaggaag gagaatcgct     1560

tgaaccctgg aggcggaggc tgcactgagc tgaggtcatg ccattgtact ccagcctggg     1620

caacaagagc aaaactccgt ctcaaaaaaa aaaaaaaaaa aaaaaaa                   1667


<210> 708
<211> 5833
<212> DNA
<213> Homo sapiens

<400> 708
agatttaatc cagagactga cttcactata gaacccacag ttgtatcaat ggttggggaa       60

agatagtggc aacaggcaaa ggagaaacag ctctgacata caaagaaaat gagtatgcta      120

aagccaagtg ggcttaaggc ccccaccaag atcctgaagc ctggaagcac agctctgaag      180

acacctacgg ctgttgtagc tccagtagaa aaaaccatat ccagtgaaaa agcatcaagc      240

actccatcat ctgagactca ggaggaattt gtggatgact ttcgagttgg ggagcgagtt      300

tgggtgaatg gaaataagcc tggatttatc cagtttcttg gagaaaccca gtttgcacca      360

ggccagtggg ctggaattgt tttagatgaa cccataggca agaacgatgg ttcggtggca      420

ggagttcggt atttccagtg tgaaccttta aagggcatat ttacccgacc ttcaaagtta      480

acaaggaagg tgcaagcaga agatgaagct aatggcctgc agacaacgcc cgcctcccga      540

gctacttcac cgctgtgcac ttctacggcc agcatggtgt cttcctcccc ctccacccct      600

tcaaacatcc ctcagaaacc atcacagcca gcagcaaagg aaccttcagc tacgcctccg      660

atcagcaacc ttacaaaaac tgccagtgaa tctatctcca acctttcaga ggctggctca      720

atcaagaaag gagaaagaga gctcaaaatc ggagacagag tattggttgg tggcactaag      780

gctggtgtag tccggtttct tggggagacc gactttgcca agggggagtg gtgtggcgtg      840

gagttagatg agccacttgg gaagaatgat ggcgctgttg ctggaacaag gtattttcag      900

tgtcaaccca aatatggctt gttcgctcct gtccacaaag ttaccaagat tggcttccct      960

tccactacac cagccaaagc caaggccaac gcagtgaggc gagtgatggc gaccacgtcc     1020

gccagcctga agcgcagccc ttctgcctct tccctcagct ccatgagctc agtggcctcc     1080

tctgtgagca gcaggcccag tcggacagga ctattgactg aaacctcctc ccgttacgcc     1140

aggaagatct ccggtaccac tgccctccag gaggccctga aggagaagca gcagcacatt     1200

gagcagctgc tggcggaacg ggatctggag agggcggagg tggccaaggc cacgagccac     1260

gtgggggaga tagagcagga gctagctctg gcccgggacg gacatgacca gcatgtcctg     1320

gaattggaag ccaaaatgga ccagctgcga acaatggtgg aagctgctga cagggagaag     1380

gtggagcttc tcaaccagct tgaagaggag aaaaggaagg ttgaggacct tcagttccgg     1440

gttgaagaag aatcaattac caaaggtgat cttgagacgc agaccaaact ggagcatgcc     1500

cgcattaagg agcttgaaca gagcctgctc tttgaaaaga ccaaagctga caaactccag     1560

agggagttag aagacactag ggtggctaca gtttcagaaa agtcacgtat aatggaactg     1620

gagaaagacc tagcattgag agtacaggaa gtagctgagc tccgaagaag gctagagtcc     1680

aataagcctg ctggggatgt ggacatgtca ctttcccttt tgcaagagat aagctctttg     1740

caagaaaagt tagaagtcac ccgtactgac caccagagag aaataacttc tctgaaggag     1800

cattttggag cccgggaaga aactcatcag aaggagataa aggctctgta taccgccacg     1860

gaaaagcttt ccaaagagaa cgagtcattg aaaagcaagc tggagcatgc caacaaagag     1920

aactcagatg tgatagctct atggaagtcc aaactggaga ctgccatcgc atcccaccag     1980

caggcgatgg aagaactgaa ggtatctttc agcaaagggc ttggaacaga gacggcagaa     2040

tttgctgaac taaaaacaca aatagagaaa atgagactag attaccaaca cgaaatagaa     2100

aatttgcaga atcaacaaga ctctgaacgg gctgcccatg ctaaagagat ggaagccttg     2160

agggctaaac tgatgaaagt tattaaagaa aaggaaaaca gtctggaagc catcaggtcg     2220

aaactggaca aagcagaaga ccagcatctc gtagaaatgg aagacacgtt aaacaaatta     2280

caggaagctg aaataaaggt aaaggagcta gaggtactgc aagccaaatg caatgaacaa     2340

accaaggtta ttgataattt tacatcacag ctcaaggcta ctgaagaaaa gctcttggat     2400

cttgatgcac ttcggaaagc cagttccgaa ggtaaatcgg aaatgaagaa acttagacag     2460

cagcttgagg cagctgagaa acagattaaa catttagaga ttgaaaagaa tgctgaaagt     2520

agcaaggcta gtagcattac cagagagctc caggggagag agctaaagct tactaacctt     2580

caggaaaatt tgagtgaagt cagtcaagtg aaagagactt tggaaaaaga acttcagatt     2640

ttgaaagaaa agtttgctga agcttcagag gaggcagtct ctgttcagag aagtatgcaa     2700

gaaactgtaa ataagttaca ccaaaaggag gaacagttta acatgctgtc ttctgacttg     2760

gagaagctga gagaaaactt agcagatatg gaggcaaaat ttagagagaa agatgagaga     2820

gaagagcagc tgataaaggc aaaggaaaaa ctggaaaatg acattgcaga aataatgaag     2880

atgtcaggag ataactcttc tcagctgaca aaaatgaacg atgaattacg tctgaaagaa     2940

agagatgtag aagaattaca gctaaaactt acaaaggcta atgaaaatgc aagttttctg     3000

caaaaaagta ttgaggacat gactgtcaaa gctgaacaga gccagcaaga agcagctaaa     3060

aagcatgagg aagaaaagaa agaattggag aggaaattgt cggacctgga aaagaaaatg     3120

gaaacaagcc acaaccagtg tcaggagctg aaagccaggt atgagagagc cacttctgag     3180

acaaaaacca agcatgaaga aatcctacag aacctccaga agacgctgct ggacacagag     3240

gacaagctga agggcgcacg ggaggagaac agtggcttgc tgcaggagct ggaggagctg     3300

agaaagcaag ccgacaaagc caaagctgct caaacagcgg aagatgccat gcagataatg     3360

gaacagatga ccaaagagaa gactgagact ctggcctcct tggaggacac caagcaaaca     3420

aatgcaaaac tacagaatga attggacaca cttaaagaaa acaacttgaa aaatgtggaa     3480

gagctgaaca aatcaaaaga actcctgact gtagagaatc aaaaaatgga agaatttagg     3540

aaagaaatag aaaccctaaa gcaggcagca gctcagaagt cccagcagct ttcagcgttg     3600

caagaagaga acgttaaact tgctgaggag ctggggagaa gcagggacga agtcacaagt     3660

catcaaaagc tggaagaaga aagatctgtg ctcaataatc agttgttaga aatgaaaaaa     3720

agagaatcca agttcataaa agacgcagat gaagagaaag cttccttgca gaaatccatc     3780

agtataacta gtgccttact cacagaaaag gatgccgagc tggagaaact gagaaatgag     3840

gtcacagtgc tcaggggaga aaacgcctct gccaagtcct tgcattcagt tgttcagact     3900

ctagagtctg ataaggtgaa gctcgagctc aaggtaaaga acttggagct tcaactcaaa     3960

gaaaacaaga ggcagctcag cagctcctca ggtaatacag acactcaggc agacgaggat     4020

gaaagagccc aggagagtca gattgatttc ctaaattcag taatagtgga ccttcaaagg     4080

aagaatcaag acctcaagat gaaggtggag atgatgtcag aagcagccct gaatgggaac     4140

ggggatgacc taaacaatta tgacagtgat gatcaggaga aacagtccaa gaagaaacct     4200

cgcctcttct gtgacatttg tgactgcttt gatctccacg acacagagga ttgtcctacc     4260

caggcacaga tgtcagagga ccctccccat tccacacacc atggcagtcg gggtgaggaa     4320

cgcccatact gtgaaatctg tgagatgttt ggacactggg ccaccaactg caatgacgac     4380

gaaaccttct gatgaagcct ccagtggaga actgggcttg ctcagacgca ctcgcattga     4440

cacaacgtaa caccagcatt gtgtgtgcag acttcaggag aactcatgtt attttttaac     4500

cccgtcaaca aatctaggaa aatattttga tcttcaacaa attgcccttt agtctccccg     4560

tatgagttag aataataaat atttagtagg tgagttttca cctcgaattt tgttttcttg     4620

atttttacgt ttgaagacat tgcaccagat gccattacat ttattggccc cccgaccttg     4680

tagaaaaacc cctaccctca caatacctta tttaagtaac tttaaattat gccgttactt     4740

ttcatatttg cactaagata tttccaggct gcatttgtat atttagattt tttggttaag     4800

ctttgacact ggaatgagtt gaaaaaatgt gccattttgc attttcatct actcatttaa     4860

agtattttat tcttattcaa agaaatatct gagctctttg cactacctgt tatcagtagt     4920

gcctttactt caggcttgat aatacttagg tgtgattata aaatcatgaa gcaggtaaag     4980

ggaggggcaa gcccccaaac tgctgtgggg acattttata atctatatgc tgcacccact     5040

taatctactg tggtgttttg tttattagtt ttgcataatt tcagcttcta tatattgtat     5100

gtatatattt tttaaaaatc tatattttgg gaaaaaaaca tacacaatgt gtctttcttt     5160

ttggacattt acctttttga aaaagaaaac acttaaaatg atcattagga cataacagac     5220

taggccagac atagcatctt gtggctttgc aaccattttc atttgtttgt tttcctttta     5280

tttcttcacc agatttaaat aactggagga attttctcca attttttttt ccttctctgg     5340

caggtatccc cagcagtcaa ttaacaataa gccagtataa aacacctaaa taaccaatct     5400

acaatctccc ttcacaagtt tttttactgt ttttagatga atgtacgatg agaaattcaa     5460

cgttaataat tctggatttt cttatcacaa aaaagaaaat gaaggacctc aaagcacctg     5520

aacagtttat cgaccagttt gaatctattt atcttcattt gaatgtcttc tagaatatgt     5580

aaaaagtcat aaaatgtatc ttccatgcta catgtacaat aagaacttct ataattgtat     5640

atatgccttt gatgtatttt cccctcaaga ttatcaactg tgtgttcgac agtgaatatt     5700

caatctggta ccagttgaaa tttttggtta taaatgtaat acgaattgtt tcacaaacag     5760

aaaacatgta aagcagtatt aaaatttggc caaacaagtg ttctgtatct actttaataa     5820

atggttattc ttt                                                        5833


<210> 709
<211> 1147
<212> DNA
<213> Homo sapiens

<400> 709
gcgcgcagtt tcccgcatgc tcagtagctg aggtagggat gccatccttc tcaaaagact       60

tattgacagt gccaaagctc ggtactggac acaacgaggg acctgggtct acgataacgc      120

gcttttgctc ctcctgaagt gtctttggtc caacgttgtt ccagagtgta ccatggcttc      180

cagtaacact gtgttgatgc ggttggtagc ctccgcatat tctattgctc aaaaggcagg      240

aatgatagtc agacgtgtta ttgctgaagg agacctgggt attgtggaga agacctgtgc      300

aacagacctg cagaccaaag ctgaccgatt ggcacagatg agcatatgtt cttcattggc      360

ccggaaattc cccaaactca caattatagg ggaagaggat ctgccttctg aggaagtgga      420

tcaagagctg attgaagaca gtcagtggga agaaatactg aagcaaccat gcccatcgca      480

gtacagtgct attaaagaag aagatctcgt ggtctgggtt gatcctctgg atggaaccaa      540

ggaatatacc gaaggtcttc ttgacaatgt aacagttctt attggaattg cttatgaagg      600

aaaagccata gcaggagtta ttaaccagcc atattacaac tatgaggcag gaccagatgc      660

tgtgttgggg aggacaatct ggggagtttt aggtttaggc gcctttgggt ttcagctgaa      720

agaagtccct gctgggaaac acattatcac aactactcga tcccatagca acaagttggt      780

tactgactgt gttgctgcta tgaaccccga tgctgtgctg cgagtaggag gagcaggaaa      840

taagattatt cagctgattg aaggcaaagc ctctgcttat gtatttgcaa gtcctggttg      900

taagaagtgg gatacttgtg ctccagaagt tattttacat gctgtgggag gcaagttaac      960

cgatatccat gggaatgttc ttcagtacca caagggtgtg agccaccgca cctggcctaa     1020

accagatttc tttagggcac aattttttct ggaatctcac tcttgttttt caaattttaa     1080

aaacgtttct actccaatta agaatatata tgatgttatt atatatgctt atgaaacaga     1140

tttatga                                                               1147


<210> 710
<211> 547
<212> DNA
<213> Homo sapiens

<400> 710
gctgcaggaa aggtaggacc tgatggctcc aggccctcgg aggctcagag gcgcagggct       60

gagccatggg aacgaagcgc gaggccatcc tgaaggtgct ggagaacctg acaccggagg      120

agctcaagaa gttcaagatg aagctgggga cggtgccgct gcgcgagggc tttgagcgca      180

tcccgcgggg cgcgctcggg cagctagata tcgtggacct caccgacaag ctggtcgcct      240

cctactacga ggactacgca gccgagctcg tcgtggccgt gctgcgcgac atgcgcatgt      300

tggaggaggc cgcacggctg cagcgggctg cgtgagggcc actctgagct ggaggcgggt      360

caaggcaaaa ggagtaatgc aacgcctgtg aagccagccc cacgcgcgca ccagtcgcgt      420

aagacaacag cagtgtctcc acctcgggga ccaaggacgc ctccgtgcct ccagaccccg      480

cctcctccag cccctgcacc tgtcatttat tcttccactg cccaataaat attcatggca      540

gacttta                                                                547


<210> 711
<211> 1109
<212> DNA
<213> Homo sapiens

<400> 711
tttctacccg accgcatttt acgtggtgct gcatttccgg tagcggcggc gggaaatcgg       60

ctgtgggaga gaggctaggc ctctgaggag gcgaatccgg cgggtatcag agccatcaga      120

accgccacca tgacggtggg caagagcagc aagatgctgc agcatattga ttacaggatg      180

aggtgcatcc tgcaggacgg ccggatcttc attggcacct tcaaggcttt tgacaagcac      240

atgaatttga tcctctgtga ctgtgatgag ttcagaaaga tcaagccaaa gaactccaaa      300

caagcagaaa gggaagagaa gcgagtcctc ggtctggtgc tgctgcgagg ggagaatctg      360

gtctcaatga cagtagaggg acctcctccc aaagatactg gtattgctcg agttccactt      420

gctggagctg ccgggggccc agggatcggc agggctgctg gcagaggaat cccagctggg      480

gttcccatgc cccaggctcc tgcaggactt gctgggccag tccgtggggt tggcgggcca      540

tcccaacagg tgatgacccc acaaggaaga ggtactgttg cagccgctgc agctgctgcc      600

acagccagta ttgccggggc tccaacccag tacccacctg gccgtggggg tcctccccca      660

cctatgggcc gaggagcacc ccctccaggc atgatgggcc cacctcctgg tatgagacct      720

cctatgggtc ccccaatggg gatcccccct ggaagaggga ctccaatggg catgccccct      780

ccgggaatgc ggcctcctcc ccctggatgc gaggccttct ttgacccttg gccacagagt      840

atggaagtag ctccgcagag gcgtgggctc gattcctcag ggccacgtta ccacagacct      900

gtttgtttct tatgctgttg ttcgtggagt ctcatgggat tgtctggttt ccttacaggg      960

ccccctcccc cgggaatgcg cccaccaagg ccctagactc atcttggccc tcctcagctc     1020

cctgcctgtt tcccgtaagg ctgtacatag tccttttatc tccttgtggc ctatgaaact     1080

ggtttataat aaactcttaa gagaacatt                                       1109


<210> 712
<211> 3650
<212> DNA
<213> Homo sapiens

<400> 712
ggggcgcggg gcgcgggggc tgtagggagg gggaccagtg gcagagggac cttaggtgat       60

ccttagaaat aaaggctagc ttctgttcga ccttggagta gggcgaagag gtgtagacag      120

gcctggagaa gcgaggtaaa agcctgagta aaagcaagaa gttggagaat atgagataca      180

tctcatctct agtaaatact taaatgactt cccctcctcc cggagtcaag cacaattcgg      240

ggatgcaatg acggacgtag gtgaagacac tgcgggaact tacagacaaa actggtttgt      300

ggcctgtttg attcctgtca gaggtttgct gacccaagac agtatcgaaa atgcatatta      360

agtcaattat tctagaggga ttcaagtcct atgctcagag gaccgaagtc aatggttttg      420

accccctctt caatgctatc actggcttaa atggtagtgg gaaatccaac atattggact      480

ccatctgctt tttgctgggc atctccaacc tgtctcaggt tcgggcttct aatttacaag      540

atttagttta caaaaatggg caggctggta ttaccaaagc ctctgtgtca atcacttttg      600

ataattctga caaaaagcaa agtcctttag gatttgaggt tcatgatgaa atcacagtaa      660

caaggcaggt ggttattggt ggtagaaata aatatttaat caatggagtc aatgccaaca      720

acaccagagt acaggatctc ttctgttctg ttggccttaa tgttaacaac cctcactttc      780

tcatcatgca gggccgaatt acaaaagtat tgaatatgaa acctccagag attttatcca      840

tgatagaaga agcagctgga accaggatgt atgaatacaa aaaaatagct gcacagaaaa      900

ctatagaaaa aaaggaggct aagctgaaag aaattaagac gatacttgaa gaagagatta      960

ctccaaccat tcaaaaatta aaagaggaaa gatcgtccta cttggagtac caaaaagtaa     1020

tgagagaaat agaacatttg agtcgtttat atattgctta tcagtttttg ctggctgaag     1080

ataccaaagt acgctcagct gaggaattaa aagaaatgca agataaagtt ataaagcttc     1140

aggaagaatt gtctgagaat gataaaaaaa taaaagcact taatcatgaa atagaagaat     1200

tggaaaaaag aaaagataag gaaactggag gtatacttcg atctttagaa gatgctcttg     1260

cagaggctca gcgagttaat actaaatctc aaagcgcatt tgatctcaag aagaaaaatc     1320

tggcatgtga ggaaagcaaa cgcaaagagc tggaaaaaaa tatggttgag gactcaaaaa     1380

ctttagcagc aaaggaaaaa gaggttaaaa agataacaga tggactgcat gcccttcaag     1440

aagcaagtaa taaagatgct gaagctctgg cagctgcaca gcagcacttc aatgctgttt     1500

ccgctggcct gtccagtaat gaagatggag cagaagcaac tcttgctggt caaatgatgg     1560

cctgtaaaaa tgatataagt aaagctcaga cagaagccaa acaggctcag atgaagttga     1620

agcatgctca acaggaatta aagaataaac aagctgaagt taagaagatg gatagtggct     1680

acaggaagga tcaagaagct ctagaagctg taaaaagact taaagaaaaa cttgaagctg     1740

aaatgaaaaa gctaaattat gaagaaaata aagaggaaag ccttttggaa aagcgcaggc     1800

agctgtctcg tgatattggt agattgaaag aaacatatga agctctatta gccagatttc     1860

ccaatcttcg atttgcatac aaggatccag agaagaactg gaatagaaat tgtgtgaaag     1920

gacttgtggc ttctctgatt agtgtgaaag acacttctgc aaccacagct ttagaattag     1980

tggctggaga acgactctac aatgttgtag tagacacaga agttactggt aaaaagctac     2040

tagaaagggg ggaactgaaa cgtcgataca ctataattcc actcaataaa atttcagcca     2100

gatgtattgc accagaaact ctgagagttg ctcagaatct tgttggccct gacaacgttc     2160

atgtggctct ttccttggtt gaatataaac cagaacttca gaaagcaatg gagtttgtct     2220

ttggaacaac atttgtttgt gacaatatgg ataatgccaa aaaagtggcc tttgataaga     2280

ggataatgac tagaactgta actctcggag gtgatgtgtt tgatcctcat gggacattga     2340

gtggaggtgc tcgatcccag gcagcttcca ttttaaccaa gtttcaagaa ctcaaagatg     2400

ttcaggatga actgagaatc aaagagaatg agctgcgggc tctagaagag gaattagcag     2460

gtcttaaaaa cactgctgaa aagtatcgcc aactaaaaca gcagtgggag atgaaaactg     2520

aagaggcaga tttattacaa accaagctcc agcaaagctc atatcacaag caacaagaag     2580

aattagatgc ccttaaaaaa accattgagg aaagtgagga gactttgaaa aacactaaag     2640

aaatccaaag aaaagcagaa gaaaaatatg aagtattgga aaataaaatg aaaaatgcag     2700

aagctgaaag agagcgagaa ctgaaagatg ctcagaaaaa actggattgt gccaaaacaa     2760

aggcagatgc atctagcaag aagatgaaag aaaaacaaca ggaagttgaa gctatcactc     2820

tggaactgga agagctcaag agagagcata catcttacaa acaacagctt gaagctgtaa     2880

atgaagctat caaatcctat gaaagtcaga ttgaagtaat ggcagctgag gtggctaaaa     2940

ataaggagtc agtaaataaa gctcaagaag aggtgaccaa gcaaaaagag gtgataacag     3000

cccaagacac tgtaattaaa gctaaatatg cagaagtggc aaaacacaag gagcaaaaca     3060

atgattctca gcttaaaatt aaggaattag accacaacat cagcaaacat aaacgggagg     3120

ctgaagatgg tgctgcaaag gtatccaaaa tgttgaaaga ttatgactgg attaatgcag     3180

agagacacct ctttggccaa cccaatagtg cctatgattt caaaactaac aaccctaaag     3240

aagctggtca gagacttcag aagttgcaag aaatgaagga gaaactagga agaaatgtca     3300

atatgagagc tatgaatgta ttgacagaag ctgaagagcg atacaatgac ttgatgaaga     3360

agaagagaat tgtagaaaat gacaaatcca aaattcttac aactatagaa gaccttgacc     3420

agaagaaaaa ccaagcccta aatattgcat ggcaaaaggt gaacaaggac tttgggtcta     3480

ttttttctac tcttttgcct ggtgctaatg ctatgcttgc accaccagag ggtcaaactg     3540

ttttggatgg tctggagttc aaggttgcct tgggaaatac ctggaaagaa aacctaactg     3600

aacttagtgg tggtcagaga caaaaacagc agaaccatac tacaggttaa                3650


<210> 713
<211> 552
<212> DNA
<213> Homo sapiens

<400> 713
ggaggccgct gggacgcggt tcagctcatt ccctgaggcc ggcccgcgtc ccgtcaggcg       60

ccgcgcgggg ttagcgcggg gtcagcggag gtcagcgggg gtcagcagca gcggctccga      120

gggcgcggcg gacgcaggat gtacacgctg ctgtcgggct tgtacaagta catgtttcag      180

aaggacgagt actgcatcct gatcctgggc ctggacaatg ctgggaagac gaccttcctg      240

gagcagtcga aaacccgatt taacaagaac tacaagggga tgagtctatc caaaatcacc      300

accaccgtgg gcctaaacat cggcactgtg gatgtgggaa aggctcggct catgttctgg      360

gacttaggag ggcaggaaga gctgcagtct ttgtgggaca aggacaagac aaagtgtggg      420

gacctgggga ccctgcactc ctccaaagtg agtgcctcct ttcggctcag agaccttgct      480

gctgaccacc acaggacaca gaaatggcaa agaccagatg tggggacggc aggatggctg      540

cctctcccct ga                                                          552


<210> 714
<211> 1426
<212> DNA
<213> Homo sapiens

<400> 714
gaggaaagag gcgcgttcct agccgcggga ctgggtgacc cgcctctccc ccaaattagc       60

tgcttggaaa gaggaccaaa gacgtctaaa aagtcatttg gaaatatctc taaatatttg      120

ttaccatgta taagctgcta aagagaaatt gggcccaaca aaactaattg aataattgag      180

gcagatttgt gtgtatcatc aaattctatc cagaagttga agaatctgaa tttaaagatt      240

gtgtgcattt aataagagga tgacctttca gtttaatttc actatagaag accatctgga      300

aaatgaatta acacccatta gagatggagc tttgaccctg gattcctcaa aagagctgtc      360

agtctcagaa agtcaaaaag gagaagagag ggacagaaaa tgttctgcag aacaatttga      420

cttgcctcag gatcacttgt gggaacataa gtcaatggaa aatgcagctc cctctcaaga      480

cacagacagt ccactcagtg cagccagcag ttcaaggaac ttggagccac atggaaaaca      540

gccctccttg agagctgcca aagagcatgc tatgcctaaa gatttaaaga agatgttaga      600

aaataaagtc atagaaacat taccaggttt ccagcatgtt aagttatcag tagtgaaaac      660

catcttgttg aaagagaact tccctggaga aaacatagtt tcaaaaagct tttcttctca      720

ctctgatctg attacaggtg tttatgaggg aggcttaaaa atctgggaat gtacctttga      780

cctcctggct tatttcacaa aggccaaagt gaaatttgct gggaaaaaag tcttggatct      840

tggttgtgga tcaggtttac taggtataac tgcattcaag ggagggtcca aagaaattca      900

ctttcaagat tataacagta tggtgattga tgaagtaacc ttacctaatg tagtagctaa      960

ctccactttg gaagatgaag aaaatgatgt aaatgagcca gatgtgaaaa gatgcaggaa     1020

accaaaagta acacaactat ataaatgccg atttttttct ggtgagtggt ctgagttttg     1080

taagcttgta ctaagtagtg aaaaactttt tgtaaaatat gatctcattc tcacctcaga     1140

aaccatttac aacccagatt attatagtaa tttgcaccag actttcctta gactgttaag     1200

taaaaatgga cgtgtacttt tggccagcaa agcacattat tttggtgtag gtggaggtgt     1260

tcatctcttt cagaagtttg tagaagaaag agatgttttt aagaccagaa tactcaaaat     1320

aattgatgaa ggattgaaga ggttcataat tgaaataact tttaagtttc ctggttaatt     1380

aacattcact gagtatccaa aatgaaataa acagaaggac caaaaa                    1426


<210> 715
<211> 6111
<212> DNA
<213> Homo sapiens

<400> 715
gcgctcccgc ttgccgcagc ctgcgtcgtc tgccgccacc gcgcgccttc actgacctac       60

accaccgccg ccgccgccgc cgccgccggg ctcgctggct ggcccggtgc gggcggcgga      120

ctcccgccgg agaggactgc cagcgccgcc gccgccgccg cttcggcccg ggcccgggcc      180

ccgaccccgt cccgggcccc agcgccggcc gcccgcccgg tcgggcgatg aagtgtcact      240

atgaggcgct gggggtgcgg cgcgacgcca gcgaggagga gctcaagaag gcctatcgga      300

agctggccct gaaatggcac ccggataaaa atctggataa tgccgcagaa gcagctgaac      360

aatttaaatt aatccaagca gcatatgatg tgttgagtga ccctcaggaa agagcatggt      420

atgataatca tagagaggcc ctacttaaag gtgggtttga tggcgaatat caagatgaca      480

gcttagattt gctacgctat ttcaccgtta cctgttattc tggttatgga gatgatgaaa      540

agggatttta cacggtgtat cgtaatgttt ttgaaatgat tgccaaggaa gaactagaat      600

ctgtgttaga ggaagaggtt gatgatttcc caacttttgg agactcccag agtgactatg      660

atacggtagt ccatcctttc tacgcttatt ggcagagttt ctgcactcaa aagaattttg      720

catggaagga agaatatgat acacgacagg cttcaaaccg ctgggaaaaa cgagccatgg      780

aaaaagaaaa caaaaagatt cgggacaaag caaggaaaga gaagaatgag cttgtccgtc      840

agctggtagc tttcattcgt aaaagagata aaagagtgca ggcgcatcga aaacttgtgg      900

aagaacagaa tgcagagaag gcgaggaaag ccgaagagat gaggcggcag cagaagctaa      960

agcaggccaa actggtggag cagtacagag aacagagctg gatgactatg gccaatttgg     1020

agaaagagct ccaggagatg gaggcacggt acgagaagga gtttggagat ggatcggatg     1080

aaaatgaaat ggaagaacat gaactcaaag atgaggagga tggtaaagac agtgatgagg     1140

ccgaggacgc tgagctctat gatgaccttt actgcccagc atgtgacaaa tcgttcaaga     1200

cagaaaaggc catgaagaat cacgagaagt caaagaagca tcgggaaatg gtggccttgc     1260

taaaacaaca gctggaggag gaagaagaaa atttttcaag acctcaaatt gatgaaaatc     1320

cattagatga caattctgag gaagaaatgg aagatgcacc aaaacaaaaa gtcaagtatt     1380

tgacatttcg atttatattt gctcttaggc tttctaaaaa acagaagaaa aagaaacaga     1440

aaccagcaca gaattatgat gacaatttca atgtaaatgg acctggagaa ggagtaaagg     1500

ttgatccaga agatactaac ttaaatcaag acagtgccaa agaattggaa gatagtcccc     1560

aggaaaatgt cagtgtcaca gagatcatta aaccatgtga tgatccaaaa agtgaagcta     1620

aaagtgttcc taaacccaaa ggaaagaaaa ccaaagatat gaaaaaacct gtcagagtac     1680

ctgctgaacc acaaacaatg agtgttctta tcagctgtac aacctgccat agtgaatttc     1740

catctcggaa taaacttttt gaccatctaa aggccacagg tcatgcaaga gcaccttcat     1800

catcgtcttt aaacagcgca acaagtagtc aaagcaagaa agagaaacgt aaaaacagat     1860

agagattctg cctgtgcttt tgtttgactg tctctagatt ttgaaaccaa aaaactgaac     1920

tgaaatcatc taaagagtta aaatttcagt gatctgcaat taattacatt gtggaagatt     1980

attttttatc ttgtaaaaac acttttttgg tttaatatat atttttaaaa catttcacta     2040

gtgattgaat tctacttttg ccatctgaat tgacttgaat gtcttaaaac aggtaaatac     2100

tgtaaagtgt gtattcttga tgtttattgg ctcatgtgga cagaaatgta cagggagaat     2160

tacattattt taacacacag aagtgcaact ttctgcttta ttttctgaat ttcacattac     2220

ttttacttaa tgcttttgtg ttttgttaat acttcataat atgtgaaaaa ctcggatctt     2280

ttaaaaagca tcatagatca tttttccata tgacactggt tccgatttta aaaattattt     2340

ttaaataacc gattattgat tactgtattt tttttctcaa gaacagtgat aggtagaaac     2400

taattgaaca tttggtagtc tttcaagaat agtgtctctt caaggtttta cttgatttaa     2460

tttgatattt tactggttta ccagtaaggt gtattgttca gttttttgct ccgatttgaa     2520

ttgtggaggt ggaagcaaat tagtttacat ggcatgtcct ccctaggcac agtgacagct     2580

gtaaagtatg acggaacaag gtagcagatg gtacagaatt tatactattt aagaagagat     2640

gtggtgttct tcattgagtt tttttcttca ctattttcag aagtttttgt tctttttttt     2700

ttttccatca ctcagtggag aaaagctttg ttaatgaaag attttgtgat agagctgatg     2760

cttatacatc tattctataa cagtgatgaa tattaacaca aaggaaatat ggagaactgt     2820

tataactgag tgttagaaca gtcgtgtaca ttgatcagta ttgagtccat ttttaggatg     2880

gattagtcag ttcttttcat tggtcttgaa agtaattttg gctggtcgcg gtggctcacg     2940

cctgtaatcc cagcactttg ggaggccgag gcgggcggat cacgaggtca ggagatcgag     3000

accatcccgg ctaaaacggt gaaaccccgt ctctactaaa aatacaaaaa attagccggg     3060

cgtagtggcg ggcgcctgta gtcccagcta cttgggaggc tgaggcagga gaatggcgtg     3120

aacccgggag gcggagcttg cagtgagccg agatcccgcc actgcactcc agcctgggcg     3180

acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aaagaaagta attttaaact     3240

cactggcttg aaatgtgtgc tttctgtaca atgaagttat tgctttccat atatccttga     3300

atcttcagat taacgaaatg aacaaatttt cggttacaga tcagctctca aacactaaag     3360

tccttaatgg caaggtcttt tctgatagct tcatggatag tattgatgat cagatttctt     3420

ctgtgttatt gtcttaaaaa taagcatttg aaccttaatt taaattcttt tcttttccat     3480

ttagagatat gtttttttct ttaccttcat acctttctat ttcttgctaa tttctatcac     3540

taattcctta taattgtccc tgctcccctt cttgatctct tcagggggaa tactaggcag     3600

ttttgtatct tctgatctcg taccctgaga cttcatctga atgtgctctg ccgccttctt     3660

atctgaacta gatgaattgg ccataattat gaataggaat attaatgaac cagaggacat     3720

actagtcaca tgttattata cactaaaaaa taggaagtca tcttgaaagg cagttaatgt     3780

actgcaaatg tccctatgac ttctttgctt tctcttatac caaacatgca ggtatttaat     3840

ttgtttaatg agggttgagt ggagttatgt gtcgctttta ttcggattga cgaaaatcaa     3900

ccataatttt caagggatct tcatgggttg tgactggaag ctgaccttag tcttgcgtct     3960

catcctttat gatgttgaga aatcatctaa tttctcagaa ctttttctta tctctaacac     4020

agttattacc ataataatat tgtctccatt tatcatacag gatcattatg aaagtaaaat     4080

gaagtagtat atatgaaaat gctttttaaa cacaaaagct ttatacaaaa tattgttgaa     4140

tttaaataag gtaaatcttt tttagtttat atatttgcag actatacatg ttggattaaa     4200

tgggcaatta agttttatag gaatttgctt cctaagtcta cttttgaaga ggaaaacagg     4260

aacgtaccat atattttgct aagggtaaaa tatttttggt gaattgcaga catttaattt     4320

cacttgtctg aggtaaaaca ataaactaaa atacatgggc atgcatctta cactgatctt     4380

attagaggtc agtgctaagt acccatcttg attgaagtta gctcagatgt ggagattcat     4440

agaatgaggg tccaggagaa gaaagttagg ggaaatctca ttttctttct gtaattcatt     4500

cagtggtgcc aaagctgggg gttccctaca atggctattt agactttccc tgcttcaaaa     4560

taagagcagt atccttagct ctagccaagc atttttctaa ttcctgcctt tggtcacaaa     4620

gaaggaaaag cagagctgtg aatgagttag tggaggtcaa gtcacatcag agttcatgac     4680

ctagtgattg ctggtgaagt aatattggaa ttttggtacc atgagaagac ttataaagga     4740

tttcatcaga agttttcatt ttttctaaat cctcccctac aaaattttca gattggaaat     4800

tactcttgta tttgtagaag attgtctcta aaattgtggt ttaactcacg caggaagtaa     4860

aattcctata gcaagacata gtttcatttt agaggacccc caaaatcccg tgaattctct     4920

ggtgatgatt ctagcctaac cttcaacata aaataatgaa gagaactttt aaactttttt     4980

atgaattcct aaacattacc atttatgtgg cagaagttct gttccctata atctgcaatg     5040

ctgaagtatc tctattcaat tcccttcctt atctgttaaa tttaatgtct ttatactaaa     5100

aatataggct cttgggattg gagaggaaaa attagaggtg attttcagat ttcttgttct     5160

atggaagagg aagctgagct cagggagata tgagctccac agccacagct ggttaggggc     5220

ggctgccagt agaacagggc agatgcctgg actcccaact cagtaggcct tctgttacac     5280

ctcaaaatgt gttacatggg aagaaaaaga ttaagaaaaa gcaagataat tttgaagaag     5340

gacgagagga agaggcatga acttgtccta acaatgtcaa agaatatttt aaaggtatac     5400

cagttaaagt agtgtgtggc tggtgccagt agaggtcagt caagggatcc ctgacgagaa     5460

taaagagccc agaaacaggt ccatgtttat atgggaactt gatttttgac agatacggca     5520

agctctatgg ggaaaacaat atgtactacc ttataccctt ccccaaaaac aaagggatta     5580

aagacctaaa tatgaagaca aaacttttaa atgagaatct ataaggttat tttcatgatt     5640

ttgcaaatgg gaaggatttc tttaaagcaa gacacaaaag catacacagg aaaaaatgat     5700

gcataaaaac atggcttctg tagaacaata gagactgtaa aagaacaagc tacagacaag     5760

gaaatgtttg caatgcatgg aactgtcaaa ggattcgtat ctggaataca ttaaagaagc     5820

aaaagaacct catacaaaag tcattgagta aatgacagcc atgcattaga acagcaattc     5880

tcaaaacttt tggtctcaag atccctttac actcttcaaa agtgagaacc ccaaagagtt     5940

ttcatgtatg tgggttaaat ctattgatat tttctgttag aatttaaaaa ttatgttaaa     6000

aaaataagaa gaatgactat ttttcaaaac aaaaaatgag aagagtggta ttgttttaca     6060

tttttacaaa tctctttaac atttagctta ataaaagata gctggcctct c              6111


<210> 716
<211> 1885
<212> DNA
<213> Homo sapiens

<400> 716
cggcgtcccc ggggcccact cccgagcgca ggcgggcagc caggcgggcg gcgcggcgcg       60

ggccggcagg aagcgtattc tgggcacggg gcgccgggcg ggccggctgc gccgagcggc      120

agtggtggga taccacccaa ggcctcgcgc ggcgccgccc gtcgaggggc gggcggcggc      180

gtagccactg ggccgtcgaa gagcgcagga ggccggtggg ccgggccggg ccgcgcggcg      240

cagccatgcc tggctttacg tgctgcgtgc caggctgcta caacaactcg caccgggaca      300

aggcgctgca cttctacacg tttccaaagg acgctgagtt gcggcgcctc tggctcaaga      360

acgtgtcgcg tgccggcgtc agtgggtgct tctccacctt ccagcccacc acaggccacc      420

gtctctgcag cgttcacttc cagggcggcc gcaagaccta cacggtacgc gtccccacca      480

tcttcccgct gcgcggcgtc aatgagcgca aagtagcgcg cagacccgct ggggccgcgg      540

ccgcccgccg caggcagcag cagcaacagc agcagcagca gcaacagcag caacagcagc      600

agcagcagca acagcagcag cagcagcagc agcagcagca gtcctcaccc tctgcctcca      660

ctgcccagac tgcccagctg cagccgaacc tggtatctgc ttccgcggcc gtgcttctca      720

cccttcaggc cactgtagac agcagtcagg ctccgggatc cgtacagccg gcgcccatca      780

ctcccactgg agaagacgtg aagcccatcg atctcacagt gcaagtggag tttgcagccg      840

cagagggcgc agccgctgcg gccgccgcgt cggagttaca ggctgctacc gcagggctgg      900

aggctgccga gtgccctatg ggcccccagt tggtggtggt aggggaagag ggcttccctg      960

atactggctc cgaccattcg tactccttgt cgtcaggcac cacggaggag gagctcctgc     1020

gcaagctgaa tgagcagcgg gacatcctgg ctctgatgga agtgaagatg aaagagatga     1080

aaggcagcat tcgccacctg cgtctcactg aggccaagct gcgcgaagaa ctgcgtgaga     1140

aggatcggct gcttgccatg gctgtcatcc gcaagaagca cggaatgtga actggtgccc     1200

cggcagcctg ctggactccc agaccccatc cagccagggg accgcaggcc attgttgaac     1260

tcctctatac tcctgggcac tggttgacag tactgaggct taaggcagct ggactctctt     1320

gctggtgacc tggcatcctc aattgtttcc tcctgaagtg gaagctgggg ccttagactc     1380

tgccctggtg acaccagcaa ttatgacttt gtctaccctt cctccccagt tattgttgca     1440

gattctggtt aagcagaggc ttcagaacca ctgaacttga aacttaccct ctagggatgc     1500

aggtgggatg tccagggact ataggtttgg gaaaaccata ccttaaggtt ggtcagcagt     1560

cagacaactc taatgtgtgt agtgataaga gattcaagta acatcagttc tcctcctttt     1620

catgcttttc cttcccaggt gcagcctgtg attctgatgg ggactggtaa atctgtgcct     1680

ctgcctccta ggacttattt tcccaggagg ccatttacaa ggggatctgg atgacctgct     1740

gatggagatc cagcttgcca gggacttagg tttatcctgt tttgtttgct actggttaca     1800

aattctattt tctgtacaat tagtcagact aaagttttca ctgtgtttgt ttggcaaaac     1860

aaattaaaca aaaagtaagg ttttt                                           1885


<210> 717
<211> 4865
<212> DNA
<213> Homo sapiens

<400> 717
acgcgcatgg aacgcagcga aggactatgg caggggagaa cttcgctacg ccgttccacg       60

ggcacgtggg ccgcggcgcc ttcagcgacg tgtacgagcc cgcggaggac acgtttctgc      120

ttttgaacgc gctggaggca gcggctgccg aactggcagg agtggaaata tgcctggaag      180

tagggtcagg gtctggtgta gtatctgcat tcctagcctc tatgataggc cctcaggctt      240

tgtacatgtg cactgatatc aaccctgagg cagcagcttg taccctagag acagcacgct      300

gtaacaaagt tcacattcaa ccagttatta cagatttggt caaaggcttg ctaccaagat      360

tgaccgaaaa agttgatctt ctggtgttta atccccccta tgtagtgact ccacctcaag      420

aggtaggaag tcacggaata gaggcagctt gggctggtgg caaaaatggt cgggaagtca      480

tggacaggtt ttttcccctg gttccagatc tcctttcacc aaaaggatta ttctatttag      540

ttaccattaa agaaaacaac ccagaagaaa ttttgaaaat aatgaagaca aaaggtctgc      600

aaggaaccac tgcactttcc agacaagcag gccaagaaac tctttcagtc ctcaagttca      660

ccaagtctta gcatacagtg tgtgcccaga actactggaa actgaatgca tttagcatat      720

tttgaaactg aagtcattca ttaggtaaca aggaatttta tcagaaattt gtcattaaaa      780

aaaggtagaa aggtggaaca ttccctttca gtcaggccta tagaattatt tgcacaagta      840

caagtaaata tgtgtattat atttatagtt tgcattttaa atataaaaat tatgtatgaa      900

atatttattt cagcattatg tggtaaggca atggaattga tctggcaaat gtcttttttt      960

tcataccagt ccataaaggc agtttgcttt cagatggcag ggccagcaac acaccttcat     1020

tgtcgtatct ccggtgtgta tcagctctcc aactctatgt cataattcag ttcatgggga     1080

tcttgattac ctttcccttc cacaaaatat tacactgatt ggttatatcg atgacattat     1140

gctgatttga cctagtgagc aagaagtagg aactacatta gacttagtgg aaagacattt     1200

gcatcagagg gtaggaaata aatatgacta caattcaagg gccttctacc ttagtgaaat     1260

tggtagggat ccagtgacat ggggcatgtt aggatatttc ttctacggtg aaggataagt     1320

acttgcatct tgctgctctt aaaaccaaga aagaggcaca atacttagtg ggcctctttg     1380

ggttttggag gcaacatttt ccaatttcat tatgttatac cagcctgttt accaattgac     1440

tcaaaaagct gctagttttg agtagggccc agaacaagaa aagagtctgc aacaggtcca     1500

ggctgctgtg caagctgctc tgccacttgg gtcatatgat ccagcagatc cagtggtgtt     1560

tcagtggcag tggcagatag ggatgctgtt tgaagcttct ggcaggtccc tataggtgaa     1620

tcttggttta ggattttaga gcaaagccgt gccattacca acaaataact agtctctttt     1680

tgagaaacag ctcttggcct gctactgggc cttagtagag actgatactt aatgagtcac     1740

caagttaccg tgcaacctga gcttcccatc atgaactgga tgttatctga gccaccaacg     1800

cacaaagttg gatatgcaca gcaacactct gtcatcagat ggaagtggta tacacatgat     1860

tgggcctgag aggccctgaa ggcacaagga agttacatga agaagtaggc caaatttccg     1920

tagtccccac ttctgctacc tgccttctct cttccagcct gcatcggtgg cttcatgggg     1980

acttccctgt gatcagctga cagagaaaga gaagacttag gcctggttta cagagtgttc     2040

tgtatgatat gcaggtacca ccctaaagtg gatagctgca gcactacatc tcacctctgg     2100

gctaccttga aggacagtgg tgaagggaaa tcctcctggt ggacacaact ttgagcagtc     2160

cccctgttga ctttgcttag aaggaaaaat agccagatat tcaattatat gccaattcat     2220

aggccgtggc cagtggtttg gctggatggt cagggagttc aatataactg gaaaattggt     2280

gacaaagaaa tttggagatg aagtatgtgg atagacactg aatgggcaaa aagggtgaag     2340

atatttgtgc cccatgtgaa tgctcaccaa agggttagca aaaaaggatt ttaataaagt     2400

ggacaagata acctgttctg tggatactag taggcctctt tctccagcca cacctgtcat     2460

cacccaattg tttcatgagc aaagtagcca tggtgacaag aatagaggtt atgcatgggc     2520

tcagcaacgt ggacttctac tcaccaaggc tgacctggcc aaggctatct ctgagtgccc     2580

agtctgccag caacagagac caacactgag cccctgatat gacaccattc cccagggtca     2640

tcagtcagtt gcctagtggc aggttcatta cattgatcca cctctatcat tgaagggata     2700

gtgttttatc cttactgaaa tagatcttac tctggataca gattcacttt cccttcgcgc     2760

agggtgtctg ctaaaactac catccgtgga cttacagaat gtctcatcta tgaccatggt     2820

attccacaca gcattacaag aaactcagtt cacagcaaaa gtgtggcagt gggcccatga     2880

tcatggaatt ttcttaccat gttccctact atcttgaatc aactggctac atagagcagt     2940

ggaatggcat tttgaagaca gtaataacac cagctatata gcagtgcctt gtagggctgg     3000

gacaaggttc tctagaagac tgtctatgct ctgaatcaac atccagtata tggtgcattt     3060

ctcttatgac tgggattcac aggtccagga atcaaggggt cagaatagga aggacaccat     3120

tcgctattag ccctggtgac ccactagcaa aatttttgct tcctgttccc atgacttatg     3180

cactgctggc ctagaggtct tacatagggt ggaatatttt ccactgagag acgcaatcat     3240

gatttaattg aactggaagt ttaagactgc tcctcagcca tttggggctt cttatgcctc     3300

taactcaata gacaaatgag ttacagtgct ggctgggtga ttgttcctga ctaccaagta     3360

gaaactggac taccccgaat ggtggtaagg taaagtatgt tgggaataca caggattcct     3420

tagggcatct cttagtgtta tcatgccctg tgattaaggt caatggaaaa ctacagccta     3480

attcagacag gaccactaat gatccagacc tttcaggaat gaaggtttgg gtcaccacca     3540

ggtaagtacc atgaccagat gaagtgcttg ctgaaggcaa agggaataca gaataaatgg     3600

tggaataaat actagctttg atcatatgac cagttacaga aacacagact gtgattgtca     3660

taagtatgtc ctccatattt tgctataact acattttgtg tgtgtgtagc tttgttttct     3720

tctcatttcc ttattctgta acataagatg cattgatttt atagcatagt gtttaaatat     3780

tgttaatttt tttaactggc tccagtgttc aaccttgatt aattttacat catagtattt     3840

aagttatggg atatcaagga gagagtaaac atcacatgaa gactttacca cctcttctgg     3900

gaaacgggtt aaagtgtttc tggtggaatg ctggattgtt aatcgtgtta gatggaatta     3960

tgaccttgtt gttgtcttta tgtggcagtt aagtatggtt taaagagatg tttatgggtg     4020

ccaagttgac aagggtaaac ttgtgatggt taattttata tgtcaacttg aataggccac     4080

agggtgccaa atatctgttt aaacattatt ctgaagtgtc ttgagtgtgt ttacagacaa     4140

gatttgcatt tgaactgggg gactcagtaa aggagatagc catccccaag gtgggtggac     4200

atcatccagt ttgttgaggg cgtaaataaa ataaaaggca gaggaaggaa gaattccccc     4260

cccttttttt tcctgcctca ttgtttgagc tgtgacatct catcttctgt cctcagatgg     4320

atttacatca ctggcttccc tggttctcaa gcctttggat tcagactgaa ttataccaca     4380

ggccttcctg ggtctccagc ttatagatga cagatcatgg gacctcttag cctccataat     4440

catgtaagcc actttcttgt agtactggta aaagatatat taaaccaatc tataaaacag     4500

atagctatga aagagaaagg tgacaggcac aagcctaggc aaatagagaa gggttcctgg     4560

acagcctctg acttgcctag gtcattgtgc acacgtggct tgcctgaatg aacatgccca     4620

ctgtgaaaga ttccatttct caacacatgt gcagtaaggg aaataaatca atgtggctca     4680

aactaaccgc ccacacatgg ggtggagcca caaggagttt gctccttatg caggggagaa     4740

gccgtgcctc ttcagctcgt gtgtggtggc ctggcattca atttgtgagg tgtaaaacct     4800

gcatgaagga cccctctttt tgtggagagc tttccttttg cctaataaat tctgccctcc     4860

tcgcc                                                                 4865


<210> 718
<211> 3847
<212> DNA
<213> Homo sapiens

<400> 718
gaagctgcgc tggggccggg ctctgagagg accggcgcag ccgcggggag cctttgaggc       60

cctccctcgg tgttttttcc cagggcgtgg gcttgccccg cgcgtgtctg tggagggcgg      120

aaacagcgga ggggccagtc tcctggcgaa ggggcctaat ccttgcccgc catgtccggg      180

ggcttcgagc tgcagccgcg ggacggcggt ccccgggtgg ccctggcgcc cggggagacg      240

gtgatcggcc gcgggccgct gctgggaata acagacaaga gagtatccag aagacatgcc      300

attcttgagg tggcaggtgg tcagctgcga atcaaaccga tacacacaaa tccatgtttt      360

taccagtctt cagagaagag tcagctctta ccattgaagc caaatctatg gtgctatttg      420

aatcctggag acagcttttc tttgttagtt gacaaataca ttttccgcat tctctctata      480

ccctctgaag tggaaatgca atgtacctta agaaacagtc aagtgcttga tgaagataat      540

atattgaatg aaacaccaaa atcccccgtg attaatttac ctcatgagac tactggtgcc      600

tcacaactgg aaggaagcac agaaatagcc aagacccaga tgactcccac aaatagtgtg      660

tctttcctag gtgaaaatag agactgcaat aagcagcagc caatccttgc cgagaggaaa      720

agaatccttc caacttggat gttagcagaa catttaagtg atcaaaacct ttcagtacca      780

gcaatcagtg gaggtaatgt aatccaggga agtggaaaag aagaaatctg caaagataaa      840

tcccagctaa acacaaccca gcaaggaaga aggcaattaa tttcatcagg aagttcagaa      900

aatacatcag cagaacaaga cacaggagaa gagtgcaaaa atactgatca ggaagagtct      960

accatttcat ccaaggaaat gccacaatca ttttctgcaa tcacattaag taacacagag     1020

atgaataata ttaagactaa tgcacagaga aacaaacttc caatagagga acttggtaaa     1080

gtttctaaac ataaaattgc cactaaaaga acaccacata aagaagatga ggcaatgagc     1140

tgttctgaaa attgttcgag tgcccagggc gactcacttc aggatgagtc tcaagggtct     1200

cattctgagt ccagctctaa tccctccaat cctgaaactt tgcatgcaaa ggcaactgat     1260

tcagttctac aaggttctga aggaaacaag gtcaagagga catcctgcat gtatggggca     1320

aactgctata ggaagaatcc tgttcatttt caacatttta gccatcctgg tgatagtgat     1380

tatggaggtg tacaaatcgt gggccaagat gagactgatg accggcctga atgtccctat     1440

ggaccatcct gttataggaa gaatccccag cacaagatag aatatagaca taatacgctt     1500

ccagtgagaa atgttttaga tgaagataat gataatgttg ggcaacccaa tgagtatgac     1560

ctgaacgaca gctttctaga tgatgaggaa gaagactatg agccaacaga tgaagattct     1620

gactgggaac caggaaagga agatgaagag aaggaagatg tggaagagct tttgaaagaa     1680

gcaaaaaggt ttatgaaaag aaaatagtaa ctaacttctg tagtcatatc tgccttacat     1740

ttactttttc tttgtgggaa aacatttatg aactaaggag gtacttaagt gacagttatt     1800

ttccttcttt tgatagttaa tgacttttac tactgactct ttacaaatga gacattgaaa     1860

cgtcagcctt cagtataata gatggaattt tttgttgcct tgccttttct ttcctactta     1920

aagcatctgg aaataggaag acagagaagg tagagtaaaa atggatattt tttatgtact     1980

ttgtatattg gtaataaaaa gtaaaagcca taggttgcat aaaactttgg tctttttaaa     2040

tttttttcca aagattatgg agtactctgc aagtataacc aggcaaagta catgaaaaca     2100

tgcctctttt cattgttact gaagtaattc tgtaagcaga accaggcttt aaaaaatgca     2160

gccattacat aatggcgttt tttttctagt accttagatg tgagctttgc aatttcactt     2220

actactttta tccttcaaaa cttgggaaga ttggttccaa atgggtactg aaaatagatt     2280

caactaggct gtagaagaga aatgttcacc atgtagggaa tgttattttg tgttccacat     2340

ctgcaattta ctgtatgttt gaatttaaaa gtaaaaaaac tcaaaaaact tgaccttttt     2400

tttcaaacta aagtcctagc tgattatttt aactctcagt gtgctgtctt tatattaaga     2460

atagagaaac gacataactt tctcaaatgg cattagtttt gccttagttt ttttgacctc     2520

agatgaaagt agcaagttgt ttgccagttg aaagttcaag attctggcct cccatatcaa     2580

gaagaaacca cttattctcc agttttacaa agtatctttc tgtatttctg ttctaaaact     2640

actttaagcc ctataatgct cttcatatta cgtgactttg aattgttaaa atgtagttta     2700

gaatctttaa taacagttgg gttgtgtaca cagagcagga gatatttatt gaaatcataa     2760

atcactaagc caaaagaatc tttgttaaat gctattattt tctactctaa aggaacctaa     2820

aaatttatat cttaaaagat caaaacatat ttataataat attttctcat tgctttaaaa     2880

tatatctccc agtaattata caatatttaa tatttactta aactggaaca agaataagat     2940

aaacatttct ctagactata acctattatt ctgattttta tctcttattg ttatttggga     3000

actatttttc cccttataat gtccctttag ccttggtagt ataacaaatc tacgaatgta     3060

atatttaact tattctcatc cctgccacta acttaatcct tgaagtgtta cataatctac     3120

tcctaggtat atacccagag gaattgaaaa catttccaca taaaaactgt acacaatgtc     3180

aatagaagca ttattcttaa cagccaaaaa gtataaacac ccaaagtcta tcaactatca     3240

actgggtgaa tggataagca aaacgtggta tatctgtgca atggaatatt atttggtcat     3300

aaaaaggaat aaagtactga tacatgctac aagatagatg aaccttgaag gcaagtaaaa     3360

gaagccagac acaaaaggcc acatactgta tgaactcatt tatatgaaat ttccaaaaca     3420

ggcaaatcca taaagacaga aagcaaattt gtggttgcca gggacttggg gaggaagaat     3480

ggggagtgac tgctaatgag tataggattt ccttttgagt gataaaaatg ttctaagatt     3540

agatggcagt gatggttgca caactctgta aatatattac aaacaatgca ttgtacactt     3600

tcaaagggta gatttcattg cacgtgaact atatatttca ataaatctgt cacaaaaaag     3660

taatgcaaag ggtaatacca gtcttttaga aggaaaaaaa tatttaatat caaaggatat     3720

tcttcgtagt aatgtaatag ttcatggtag ctgcttttaa cgatacagtt ttaatgcaac     3780

tttcataatc atcctgaaga cacttttgag tataactatt gtataaataa atgtatagct     3840

taattga                                                               3847


<210> 719
<211> 1432
<212> DNA
<213> Homo sapiens

<400> 719
gaagggggcg gggccgaggc tggcgggcgc ggggaaaatg gcggcggcgg cggcggcggc       60

tgcagctacg aacgggaccg gaggaagcag cgggatggag gtggatgcag cagtagtccc      120

cagcgtgatg gcctgcggag tgactgggag tgtttccgtc gctctccatc cccttgtcat      180

tctcaacatc tcagaccact ggatccgcat gcgctcccag gaggggcggc ctgtgcaggt      240

gattggggct ctgattggca agcaggaggg ccgaaatatc gaggtgatga actcctttga      300

gctgctgtcc cacaccgtgg aagagaagat tatcattgac aaggaatatt attacaccaa      360

ggaggagcag tttaaacagg tgttcaagga gctggagttt ctgggttggt ataccacagg      420

ggggccacct gacccctcgg acatccacgt ccataagcag gtgtgtgaga tcatcgagag      480

ccccctcttt ctgaagttga accctatgac caagcacaca gatcttcctg tcagcgtttt      540

tgagtctgtc attgatataa tcaatggaga ggccacaatg ctgtttgctg agctgaccta      600

cactctggcc acagaggaag cggaacgcat tggtgtagac cacgtagccc gaatgacagc      660

aacaggcagt ggagagaact ccactgtggc tgaacacctg atagcacagc acagcgccat      720

caagatgctg cacagccgcg tcaagctcat cttggagtac gtcaaggcct ctgaagcggg      780

agaggtcccc tttaatcatg agatcctgcg ggaggcctat gctctgtgtc actgtctccc      840

ggtgctcagc acagacaagt tcaagacaga tttttatgat caatgcaacg acgtggggct      900

catggcctac ctcggcacca tcaccaaaac gtgcaacacc atgaaccagt ttgtgaacaa      960

gttcaatgtc ctctacgacc gacaaggcat cggcaggaga atgcgcgggc tctttttctg     1020

atgagggtac ttgaagggct gatggacagg ggtcaggcaa ctatcccaaa ggggagggca     1080

ctacacttcc ttgagagaaa ccgctgtcat taataaaagg ggagcagccc ctgagcaccc     1140

ctgctggtgg ctctgtcctc tgttaggcac cacactggtt ggtcaacttg gatgttcatc     1200

gaggctcatt ctggccttgc tcagaagccc ttctgatgct cttcagtgag ggaggcacta     1260

ccatttgaag tgaccccatg tcagtcacat ggactggtct ttagcaaagt ccaaggctgc     1320

ctgcttccac ctaagtggtc tctgttctac actttaatgt caccctctac atcatcttac     1380

ctagcccacc caaccttata aacatgataa ttgactactt tcctgagcta aa             1432


<210> 720
<211> 5586
<212> DNA
<213> Homo sapiens

<400> 720
cgcggcttgc aaggcgcctg cgactcggtc ccaggtcggc gggcggcgca cggcgggctc       60

gcgcgggggc cccggcgcgc cgggcggcgc agtacgcagc gcgcggaccc acgccacggc      120

caggagccca gagcagcgcg gccacactgc ccaggggtcg gccctcggcc ccggcgctcg      180

gagcgcggcg gctgcctggg ctttaatggc tgctccgcgg agcagcgcct agggctggaa      240

ggcggctgcg gctcaggaag tcacccgagc aagcctcctt cggggccggc cgcacccgcc      300

gcggcgcgct ccatgggggc gcgctccccc cgggcggccc gctgacccgg gacgccgggg      360

cccgctcgct cgccggccgc gcgtcccggc catgaactga gcccgcgggc cagccccgcg      420

cctgctccgc ccgcgccttt cttctcgcgc ctcctccgcc cgccgccggc gggcccggct      480

ccccgggggc tgcggcgccc cgggctcggc ggcccgcggg ccccggggcg cggggcggcg      540

gcggcggggg gcgcgcggct ccgggcgcgg cgcctgcacc atgaactacc agcagcagct      600

ggccaactcg gctgccatcc gggccgagat ccagcgcttc gagtcggtcc accccaacat      660

ctactccatc tacgagctgc tggagcgcgt ggaggagccg gtgctgcaga accagatccg      720

ggagcacgtc atcgccatcg aagatgcctt cgtgaacagc caggaatgga cgctgagtcg      780

atctgtcccg gagctcaaag tgggaattgt gggtaacttg gccagcggca agtctgccct      840

ggtgcaccgg tacctgacgg gcacatatgt ccaggaggag tctccggaag gtggcaggtt      900

caagaaagag attgtcgttg atggacagag ctatctgctg ctgatcagag atgaaggggg      960

ccccccggag gcgcagtttg ccatgtgggt ggacgctgtt atatttgtct tcagcttgga     1020

ggatgaaata agtttccaga ccgtttacca ctactacagt cgaatggcca actatcggaa     1080

cacgagcgag attcctctgg ttctggtggg aacccaggat gccataagtt ctgctaaccc     1140

gagggtcatc gatgacgcca gggcgaggaa gctctccaac gacctgaaac ggtgcacgta     1200

ctacgagacg tgtgctacat acgggctgaa tgtggagagg gtcttccagg acgttgccca     1260

gaagattgtt gccacaagga agaagcagca gctgtccata ggaccctgca agtcgctacc     1320

taattctccc agccattcct ccgtctgttc cgcgcaggtg tctgccgtgc acatcagcca     1380

gacaagtaat ggaggtggga gtttaagcga ctattcctcc tccgttccat cgactcccag     1440

caccagccag aaggaacttc ggatcgatgt tcctcccact gccaacacgc ccacgcccgt     1500

tcgcaagcag tctaagcgcc ggtccaacct gttcacctct cggaaaggga gcgacccaga     1560

caaagagaag aaaggcctgg agagtcgtgc ggacagcatt gggagcggcc gagccatccc     1620

aattaaacag ggcatgctgt tgaagcgaag tggcaaatcg ttgaataaag agtggaaaaa     1680

gaaatatgtc accctgtgtg acaatggcgt gctgacctat catcccagtt tacatgatta     1740

catgcagaat gttcatggta aggagattga ccttctgaga accactgtga aagtcccagg     1800

gaagaggcca ccccgagcca cgtcagcctg cgcacccatc tccagcccta aaaccaatgg     1860

cctatccaag gacatgagca gtttacacat ctcacccaat tcagggaatg tcactagtgc     1920

atctgggtct cagatggcaa gcggcatcag cctggtctcc ttcaacagcc gacccgacgg     1980

catgcaccag cgctcctact cagtctccag tgccgaccag tggagtgagg ctacggtcat     2040

tgcaaactcg gccatcagca gtgacacagg gctgggtgac tccgtatgct ccagccccag     2100

tatctccagc accaccagcc ccaagctcga cccgcccccc tcccctcacg ccaacagaaa     2160

gaagcaccga aggaagaaaa gcactagcaa cttcaaagcc gacggcctgt ccggcactgc     2220

tgaagaacaa gaagaaaatt ttgagtttat cattgtgtcc ctcactggcc aaacatggca     2280

ctttgaagcc acgacgtatg aggagcggga cgcctgggtc caagccatcg agagccagat     2340

cctggccagc ctgcagtcgt gcgagagcag caagaacaag tcccggctga cgagccagag     2400

cgaggccatg gccctgcagt cgatccggaa catgcgcggg aactcccact gtgtggactg     2460

cgagacccag aatcccaact gggccagttt gaacttggga gccctcatgt gcatcgaatg     2520

ctcagggatc caccggaatc ttggcaccca cctttcccga gtccgatctc tggacctgga     2580

tgactggcca gtcgagctca tcaaggtgat gtcatccatc gggaacgagc tagccaacag     2640

cgtctgggaa gagagcagcc aggggcggac gaaaccatcg gtagactcca caagggaaga     2700

gaaggaacgg tggatccgtg ccaagtacga gcagaagctc ttcctggccc cgctgccctg     2760

cacggagctg tccctgggcc agcacctgct gcgggccacc gccgacgagg acctgcggac     2820

ggccatcctg ctgctggcac acggctcccg ggacgaggtg aacgagacct gcggggaggg     2880

agacggccgc acggcgctgc atctggcctg ccgcaagggg aatgtggtcc tggcgcagct     2940

cctgatctgg tacggagtgg acgtcacggc ccgagatgcc cacgggaaca cagctctggc     3000

ctacgcccgg caggcctcca gccaggagtg catcgacgtg ctgctgcagt acggctgccc     3060

cgacgagcgc ttcgtgctca tggccacccc taacctgtcc aggagaaaca ataaccggaa     3120

caacagcagt gggagggtgc ccaccatcat ctgaggaaca gccgtgcccg cctgctcgcc     3180

gcacctggga cgcggcagcc tcgccgcatt ctcgctcaga agtcgcagca cgtgagtccc     3240

gtcgcatccc ctccctcttc ctggtggcca cctccctccc gcccacccac tctcacccca     3300

aacaaaatca caaaacctgg acatccctca aggggcgaag aggcggccgg gagactgcag     3360

aagtggctcc ttttcataaa ctcccctaaa ccacacacag gagagagcga cgggcctcgg     3420

ccctttgatg atagcacatg gcgcaggacc cttgtcctgg tggcacaagg gatggggacg     3480

cgagggggag gggaggcgag gaacaaggag aaggggcaac tttccttaac tggcagttga     3540

gcacatagta catttcccct ctaccaaacg gaacacttgg attccatctc ttctctgagg     3600

agctcgacgg cataaatcag aagcaagcac agagtttgtc aggtttgaag cccctatgat     3660

ggtgtgtgtc aaatcagttg tagctaatct gtccagggag aatactggct tcattacact     3720

tgtacagccg agttcttccc gcattactgc tgtttaatag aacgtgatta gtcatcgccg     3780

agaagaaagc atattagccg aggaggtagt cacgcggcac gcgccggtga ttgccacgat     3840

gtgattgcaa tactcttaga agcaccatat tatcccagac atgttctttc aagcccttgg     3900

agccctctct aaattcactg tcatcattta gtatctgttt aatttttcag tccaaagaga     3960

ggaaatcagt cgctgagtat tatttgactc cggtctcctt ggtgcaaaaa caaaatggga     4020

aaaataaata agaataactc agaaactcaa aaggaaacca caaattcagc taataatagc     4080

atttcgagta tatttcgtaa actaaggaaa tacacaaaag gctgtttttt ccgactgtaa     4140

gagatatttg atgtcctttt gccgaggtgg atgtgttagt ctcaggccct cctggaccac     4200

gttgcccaag tcacacaggc ttctgtgtta tgtatttaga taagatgtgt gaaaatatat     4260

ttgaataaaa gaagttcata aatatgcatt gatttttgta cagacaaatg gcacctctct     4320

taatttataa attgaactgg atgtgaacta ataatgtgca actagttgag ataagagggt     4380

tacagatcat tgtacatgga aaatattccc agcagtaaac acttccatta atgtgatcta     4440

cggcttttga aaaggagcat ctcagaataa gatggtggta caatttgctt attaaaattg     4500

agaaagaaaa aaaaagacac actggagtat attagaaagg aaaaagaagg aatgtggtct     4560

ctcatgattg aaagcatgat ttagatcgga tacggctttt gctaaccaag gaccaaggga     4620

ctctggcaag atggggtggt tttccgaatg ccagaccgag gtgccttacg aaggcagctg     4680

ccaatggttc tgtggcacag actggctcct gagaacccag acgaccttga cctggcagcc     4740

cggccctcca cgctagtacc tcgcctgatt ttccatcgtt gcggtatcca gccgcttcag     4800

acgtccgccg ccttcagtgg tggtagtcaa atgtagtcaa ccaaaccaca gcatccctta     4860

ggttaaaagc aaacggggca gctttgccta gagctcattg acagtgtgat ggggggagaa     4920

gggttgtcac aatggaagat gaggacacta gactcatgta gcacagaaac atgaagccac     4980

acgcaccggc agcctccggg gtgttcctcg ctctctcgta tgttaaacct tatattttat     5040

aagagttttt cctcttattt cactttttaa aaaaaattaa agtaggtggg gaaaaaaata     5100

aagctttaca cagaatttat atgtgggtaa gtgtttcatg gaaatttcta atcttaacga     5160

agctaagtgg agctcactcg tatccaaaag tataacaggt gcagaagcca caagtctgag     5220

aaccttgacg acagttccat cgtcctgcca tttgattttt cagtctgcgt ttcatcactg     5280

tgtagctatt gtaaatgtga atagaaaaaa acaggtcatt gcctattttt gaagaacgcg     5340

ttggtgttcg agtccactag acacactcgc tccacacagc cttcaccgta gactctgtag     5400

tggacacaga tatagcataa atgaaattgt taaattattt cattgtagtt aattcccact     5460

ataggaatgc tttatcatag tgaagtttct tttgagaaga aacggaactc cttgaggctt     5520

ctctttggga tgtatatgag cgtgtacata ttattctatg tgtttataat ataatatttt     5580

cccaaa                                                                5586


<210> 721
<211> 2678
<212> DNA
<213> Homo sapiens

<400> 721
attctaaatg caaagctaga ctgagcaagg gaagtgacag gaaatggagc tggggagaca       60

aaaatgtgga taacaacaaa agaatttcaa caggtaaaaa aatgagtcaa acatctctca      120

aacagaaaaa gaatgagcct ggaatgaggt cctcaaaaga gagtctagaa gcagaaaaaa      180

gaaaggaatc tgacaaaaca ggagttcgtc tgagcaatca gggatcacaa gaatcatcac      240

tgcggaagac agactctcga gggtaccttg tgcgcagtca atggtctaga atatcccgga      300

gcccatccac caaggctcca tccatagatg agcctagaag caggaacacc agtgctaagc      360

tccccagcag ctccacgagc tcccggactc catccacctc cccaagcctg catgactcct      420

caccgccgcc gctgtccggg cagccctcgc tccagccacc cgcgtcgccc cagctgcccc      480

ggtcgctgga ctcgcggcct cccacgcccc cagagcccga tcctggctcc cggcgcagca      540

ccaaaatgca agagaatccg gaggcctggg cccaaggcat cgtgcgggaa atccgccaga      600

cccgggactc gcagccgctg gaatattcgc gcacgtcccc caccgagtgg aagtcctcca      660

gccagcgcag ggggatctac cccgcctcca cccagctgga ccgcaactct ctgtccgagc      720

agcagcagca gcagcgggag gacgaggacg actacgaggc tgcctactgg gcatccatga      780

ggtcgttcta cgagaagaac ccgagctgct cgcgcccctg gccgcccaaa cccaagaacg      840

ccatcaccat tgctctctca tcctgcgcgc tcttcaacat ggtggacggc aggaaaatct      900

acgagcaaga gggtctggaa aagtacatgg agtatcagct caccaatgag aacgtcatcc      960

tgaccccggg cccggcgttc cgcttcgtca aggcactaca gtatgtcaat gctagactcc     1020

gtgatctata tcctgatgaa caggacttat ttgatattgt actgatgact aataaccatg     1080

cccaagtggg agtgcggctt ataaacagcg tcaatcacta cggcttactg attgaccgct     1140

tctgtctgac cgggggaaaa gaccccattg gctatttgaa ggcatatctt accaacttgt     1200

atattgctgc agattctgaa aaagtgcaag aggcaataca agaaggtatt gcctctgcga     1260

caatgtttga tggagccaaa gacatggctt actgtgacac tcagctccgt gtagcctttg     1320

atggggatgc tgtcctcttc tctgatgagt ctgaacattt taccaaggag catgggctcg     1380

acaaattctt ccagtatgat acattatgtg aaagtaagcc tcttgctcag ggtcccctaa     1440

aaggctttct ggaagattta ggcagactgc aaaagaagtt ctatgccaaa aatgaacggt     1500

tactttgtcc tatcaggacc tacctggtta cagctaggag tgcagccagt tcaggcgccc     1560

gtgtgctgaa gacccttcga cgctggggtc tagagataga cgaagctctt ttccttgctg     1620

gagcccccaa aagtcccatc ttggtgaaga tccggcccca catcttcttt gatgaccaca     1680

tgttccacat tgaaggggca cagaggttag gttccatcgc agcttatggc tttaataaaa     1740

aattcagtag ttaggggcag ggaggagaaa taaagtggtg atagtctggt gttacagaag     1800

ccacttcttt tggctctcta ggataattag ataggtattt cagaaaattg gaccttaaaa     1860

ctttgcttct ttggaaaggt tttctcctga ttttttggaa aaccttttga accctcaagt     1920

taccatcaaa ctacttctct ttgaactacc aatactgttg aatgccatta cacctatctc     1980

tgtgtaagtc ataatgatga ctctttagga taagtttaga acttgaatat ttgcatgctt     2040

aaggcactgt tttagaagct tacttagttt tataaacact gctcattttt ggatgtttgt     2100

agataacaat gaattgttac ccatcagcat tgtagaatag tgtcttcaaa ggtagaagga     2160

gtatggttaa gcacactctt gaaaactgga gctttgtatt ctgtgactgc tatggctagc     2220

tttgtaacca aagcaaaatg agaatttcac tctacctgca tgagtataac aattttgata     2280

ctgctcattt agaaataaat catctggttg ttcctccagg gtactttcta agataagcct     2340

taaacagaaa cccctaagaa aggttctctg aaaattattt ggtgggttaa atgcctctga     2400

tccacagagt ttcatatttg aagtctccgg ctttgggcct ggcaggctgg cacatccata     2460

tttgtatgga aaaaaaaaaa aaagacccta cgctaccact tcaaaaagtg acatgaagtg     2520

tagtatcctg gcccttcatt gtcattctct catgattttt gttttgtttt caacaaaaat     2580

tggttggtca ttaaatatat catatgttag gcacagtgac ctggttattt tcacatgtta     2640

cttcattttc ttatcaaatt aaatgtttgt gacatagt                             2678


<210> 722
<211> 1856
<212> DNA
<213> Homo sapiens

<400> 722
cacccgctca gctcgaccgc ggagggcagc tccaaagggg accccaaagg tgcccacgcg       60

gggctggggc ctcctgggcg tcgttgggag cggccactac cggcccgggt ccgagctgtc      120

agcctctcca aagcctgcgc gagaggagcc gggacacgcc tagcgcgggc tccaggtggc      180

tgaccacgtc cacgaccaca tctgcctcta aactggaatt cggttgctga cccagcccca      240

gcctcggctt tcttgtcagc accagggggc acagaacacc gtctcagtgg ccggtgtcca      300

gctgcctact ttctgcccgg atctctggct cctcatctct ccggtctccg cagactaaag      360

ccctcgggat atgcagcagc catgcctgtg cacacgctga gccccggagc cccgtccgcc      420

cccgccctac cttgccgcct gcggaccagg gtccctggct acctgctacg ggggccggca      480

gatggtggag cccggaaacc gagcgctgtg gagcgcctgg aggccgacaa ggccaagtac      540

gtcaagagcc tgcacgtggc caacacccgc caggagcctg tgcagcccct gctgtccaaa      600

cagccgctct ttagccctga gactcgccgc acagtgctca cgcccagccg ccgagccctg      660

cctggcccct gccgacggcc ccagctggac ctggacatcc tcagcagcct catcgacttg      720

tgtgacagcc ccgtgtcccc tgccgaggcc agccgcactc ctggacgggc cgagggagcc      780

ggccgtcctc ccccagccac ccctccgcga ccgccgccca gtacctctgc ggtccgccgg      840

gtggacgtcc gccccctgcc cgcctcgcct gcccggccct gcccatcacc cggccctgcc      900

gccgcctcca gcccagcccg gccgccgggt ttgcaacgct ccaagtcgga cttgagcgag      960

cgcttttcta gggcagccgc tgatctcgag cgctttttta acttctgcgg cctggacccg     1020

gaggaggcga gagggttggg tgtggcccac ctggcacggg ccagctcgga tatcgtgtcc     1080

ctggcagggc ccagtgctgg gccgggcagc tctgaagggg gctgctcccg ccgcagctcg     1140

gtgactgttg aggagcgggc ccgggagcgc gttccctatg gcgtgtcggt ggtggagcgc     1200

aatgcccgcg tgatcaagtg gttgtatggg ctaaggcagg ctcgggagag cccagcagct     1260

gaaggctagg cgccactggg cctggaattc gccacaggac ggatcttaca gaggcaagtg     1320

gtccctggac ctctcttgca tccattctct agacggccgt gtcagaggct ccaccctgtt     1380

gtgaacttgg tatggaggca aaggcttaga ggctggacca gcattgttgg gcaaggactg     1440

actctccaag ggttttgttc ttggctttgg acacctgaga accccctcct cccctccccc     1500

aatacaaggt ttttgacatg agtgtactcc tgcttagttc ctcttgtggg gctgcatttg     1560

cggtgctttg ccctccccac tgtgagtgag gggccaaggg atctcctcaa tcctgtctcc     1620

ccagcggctc tgtttcctcc ttccttcctt ggcctctgtc ctttgctgac ttcctcttcc     1680

ttacccagca gaactcaccc tggggtcggg gcagtgggga ggggcctatc cactgctctt     1740

cctagtcctt ggcagctggc ctaggtgggc agactatagg agggactggt taggagtctg     1800

cattgctttg acttccctct ccttggttaa taaacacaaa tgcttgtttc tcaagg         1856


<210> 723
<211> 1335
<212> DNA
<213> Homo sapiens

<400> 723
tgatggtcaa catgtcagca ccagccatct gcctcgtgcc ctgggttgac ctgggtttag       60

gagaggatcc cacatctggg cagaaagacc ccaccccctg aaaaaagagc aaacagattt      120

cttgcatctt tcgttctatg tggctctcag aacattaaat ccaggagtgc tttaggaatt      180

gggtgcacag tgcctgccac cgaagaggag aaaatgaggt gtggaaacgt gcaaaccgtt      240

tgtgagggtc tcagcgaggc ctcttcatgc cccaggcacc accagctccc cctccccagc      300

tcgttcccag ccaggaccct cagctgtcct ctcaggcccc ctgcgacagc tgaagagtgt      360

gcgggggagg ggactagggg tccgggcggc gctggtcaca ccctcgttgc tctcactcag      420

ggcccccact cccagcccct ccccccccaa gaggctcggc actattttgg gtggtgtcga      480

ccccgccccc acctcctatc gagccctggc tctccgggca gctggagggg tcgcgctgcg      540

cctgttgggg ctgcacctcg gaccagggct tctgctgcat ctgcagccat gtcgggccgc      600

tcagtgccac atgcccaccc ggccaccgcc gagtacgaat ttgccaaccc gagccgcctg      660

ggtgagcagc gcttcggaga aggcctcctg ccagaagaga tcctgacccc cacactctac      720

catggctact atgtccggcc tcgggccgcc ccagctgggg agggcagcag ggcaggggcc      780

tccgagctta ggctcagtga gggcaagttc caggcatttc tggatgtgag ccactttacc      840

ccagacgagg tgactgtgag gactgtggat aacctgctgg aggtgtctgc ccggcacccc      900

cagcgcctgg accgccacgg cttcgtgtcc cgagagttct gccgcaccta tgtcctgcct      960

gctgatgtcg acccctggcg agtccgagct gctctctccc atgatggcat cttaaacctg     1020

gaagcacctc ggggtggccg acatttggac acagaggtca atgaggtcta catctccctg     1080

ctccctgcgc ctcctgatcc agaggaagag gaggaggcag ccatagttga gccctgattg     1140

ccacagaccc agcacccagc aaatccctct ctacctccca aggtgatatg ggcagctgcc     1200

caccactcca gaggtagcag catccttggg ggaagggaaa ggtgcatggt ccacaatgta     1260

tggtttggtc ccatgggaca tgtcatagcc ttggtttagt tttgggtgga gctgaataaa     1320

cccaaatctc agggc                                                      1335


<210> 724
<211> 1349
<212> DNA
<213> Homo sapiens

<400> 724
agtggcagcg gcggggacgg ggtcagtgcc aagatgtcga cggcggcggt tccggagctg       60

aagcagatca gccgggtgga ggcgatgcgc ctagggccgg gctggagcca ctcgtgccac      120

gccatgctgt acgccgccaa ccctgggcag ctcttcggcc gcatccccat gcgcttctcg      180

gtgctgatgc agatgcgttt cgacgggctg ctgggcttcc ccgggggctt cgtggaccgg      240

cgcttctggt cgctggagga cggcctgaac cgggtgctgg gcctgggcct gggctgcctg      300

cgcctcaccg aggccgacta cctgagctcg cacctgaccg agggcccaca ccgcgtcgtg      360

gcgcacctgt acgcgcggca gctgacgctg gagcagctgc acgccgtgga gatcagcgcg      420

gtgcactcgc gcgaccacgg cctggaggtg ctgggcctcg tgcgggtccc gctgtacacc      480

cagaaggacc gagtcggagg cttccccaac ttcctgagca acgccttcgt gagcacggct      540

aagtgccagc tcctctttgc cctcaaggtg ctcaacatga tgcccgagga gaagctggtt      600

gaggccctgg ctgcagccac cgagaagcag aagaaggccc tggagaagtt gctcccggcc      660

tcctcttgag ggctgcctga gctggtggca ccctcccctg ggccggaaga ctgggaattc      720

ctgctaagtg tggcttctag agtgtttgtg tgtaccccgc ttctgactgc ctagggcgag      780

tgggcatcct gtcatcatct ccactgtccc aagcagtcac taggtggcgg ccgggccagc      840

tggaacccag cccatcctct caggcagagc agggtggtcc gggcacactg ggcctgcctc      900

tccagcctca ggatgctctt gtttattctg ggctcagacc ctcctcttgt acgtctcatc      960

acagctggta gagacccagg agtgcctgat tgtcccacag gggtggcgca cagctctggg     1020

accactcaga agatgggatg tgtgggtgga ggatgccttg tctcggtcag ctcattcctg     1080

cctccttcct gagccagttc agggcctggg ggagagccag cttggggtag gaagttaata     1140

atactgttaa tttgggttgt tgttggattt actttgctag attttctctt tcaccacgtg     1200

tgaactgtgg gtgaggtttc aaagtagctt caccccacgt ggcttggttc ccagggacag     1260

tcagggcctc gggggcccag ctatgtacaa cgaagctgtc gaaggagaag acaataaagt     1320

cgctccgcag ctgctctgtg tgtttctca                                       1349


<210> 725
<211> 3868
<212> DNA
<213> Homo sapiens

<400> 725
gggccgtgct cttgctcccg ccgcctggca gcctcacgct cggctccagc ggccaagagc       60

cggagaaagt cctgctggtg ggcggccgcg gggctgaggg cgtccggcat cccggggccg      120

ctccggcccg ggcggcgaga gtgcccggcg gtccatgcat ccgccgccgc ccgccgccgc      180

gatggatttc agtcagaaca gcctgttcgg ttacatggag gacctgcagg agctcaccat      240

catcgagagg ccggtccgcc ggagcctcaa gacaccggaa gaaatagaaa gattgacagt      300

cgatgaagac ctcagtgata ttgaaagggc tgtttatctg ctcagtgctg gtcaagatgt      360

ccaaggaaca agtgtgattg caaatctccc atttttgatg cgacagaatc ccactgagac      420

gcttcggaga gtgttgccaa aagtcagaga agccctgcat gttgcaggag tggaaatgca      480

gttaacggct gcgatgtcat ttctgaccat tctgcaggac gaatcagtgt caattcatgc      540

atatacccac tcattcctcc aagtcattct cctgcatctg gagcacaggg acacaggtgt      600

cagcaatgca tggctggaaa ctcttctgtc tgttatagaa gtattgccaa aagaaaccct      660

acggcatgag attttgaatc cacttgtttc caaggcacaa ctttcccaaa cagtccagtc      720

tcgtttagtt agttgtaaaa ttttaggaaa attgaccaac aaatttgatg cccacaccat      780

taagcgagaa atacttcctc tggtaaaatc actctgtcaa gatgtagaat atgaagttcg      840

atcttgtatg tgtcggcaat tagaaaatat agcccagggc attgggacag aacttacaaa      900

aagtgtggtg ctccctgaat taatagaact ttctagggat gaaggcagca gtgtacgact      960

tgcagctttt gaaactttgg ttaatctgct tgatatattt gatacagatg acagaagtca     1020

aactatactt cccttagtga aatcattttg tgaaaaatct ttcaaagcag atgaatcaat     1080

tcttatttct ttatctttcc atttaggaaa actatgtcat ggactatatg gaattttcac     1140

tccagatcag cacttgagat ttttggaatt ttataagaaa ctttgtacat tgggtttgca     1200

acaagaaaat ggacacaatg aaaaccagat tccaccccaa atcctagagc aggagaagaa     1260

atatatttca gtacggaaga actgtgctta taactttccg gccatgattg tttttgttga     1320

tcctaaaaac ttccacatgg aactctattc tacattcttc tgcctttgcc atgaccctga     1380

agtaccagtc agatacacta ttgctatttg cttttatgaa gtatctaagc ttctgaattc     1440

tggagtatat ttaatacata aagaactaat aacattatta caagatgaat cactggaggt     1500

actagatgct cttatagatc atcttccaga aatcttggaa cttatgtcta ctggtggaga     1560

aagcagtgtt caagaaaata agttatcttc tctgcctgac ttgattccag cactcacagc     1620

tgctgaacag cgagctgcag cctctttaaa atggagaact catgagaagc tacttcagaa     1680

atatgcctgc ctgccacatg tcatatcaag cgatcagatt tattaccgtt tcttacaaag     1740

aatgttcaca atcatgatga caaataatgt tttacctgtc caaaaggcgg cttcacgaac     1800

tctatgcatt tttctgcgtt ataatcgtaa acaagaacag agacatgagg tcattcaaaa     1860

attaattgaa caattgggcc aaggaaaaag ttactggaat agacttcgat ttttggatac     1920

ctgtgaattt attatagaga tattttcaaa atcatttttc tgtaaatatt tctttctacc     1980

tgctattgaa ctgacacatg atccagtagc aaatgtgaga atgaaacttt gctacctgtt     2040

gcccaaagtg aaatctactc tgaagattcc tgctgataag catctacttc agcagttaga     2100

aatgtgtgtg aggaaactcc tgtgtcaaga aaaagataaa gatgttctgg ctattgtaaa     2160

aagaactgta ttagagttgg acagaatgga aatgtctatg gatgcttttc agaaaaagtt     2220

ttatgagaaa gatttgttgg atcaagagaa agaaagagaa gaactacttc ttttggaaat     2280

ggaacaatta gagaaagaaa agcaacagaa tgatggaagg cccatgagtg ataaaatgtt     2340

tgaaaagaaa cgtagagaca ctaagacacc aacgcaaagt ctgcccaaga acatccccat     2400

ttctgttcct ggaccctctt ctgtcacccc atcgacaagt aaagaaatca agaaatccaa     2460

actgattcga agccagtctt ttaataatca agcttttcat gcaaaatatg gcaacttaga     2520

gaaatgtgct agtaaaagtt ctacaacagg atatacaact tctgtctcag ggttaggaaa     2580

gacttctgtg ctttcactag ctgatgattc attccggact cgtaatgcca gtagcgttcc     2640

atcttccttt tctcctaata ctcccttacc gagtacttcc cgtgggacag gtaactcagt     2700

tgaccccaag agcagtggaa gtaaagatac acaaccacgg aaggctacct taaaatccag     2760

aaaatccaat ccttaaatca actgcttgat gaaggaggca aaacaaaggc agcaggagat     2820

aatgtgattg gtacacaaaa gctaaagcag tggctggggc tttgttttta aattttgggt     2880

tttttttttt gttgttgtta atgagcagaa agagagacat aatgacagct gatgttaaac     2940

ttttcatatt tcaaattaga ttccctagga ggtataatat atatttcttg agtaataatg     3000

tggttacgga attccaatgt tatagtgaag tgtaatgaaa aacatctcta ggaatgtgct     3060

ttaaccactg ctgcaaaaga gacaagtctg catttatttg tgcaggaaac cagccattta     3120

attgttctag agttttagca tttaaaaatc gtatgaaagt ctacatcagc tgaattgtcc     3180

tagcttgata agcacttgga gggggacttg gaaggtgaga aagatactgc attttctcat     3240

gagtctccaa gcccacttga aaagtcacac tgaaaggatg caaatagccg tctgcgattt     3300

tggcggccct ccggattgtg gtgacaatat gttgtacccg gacattccca aatttaaatt     3360

tggcagtgaa aattccacaa agatttctgg taactttgag ctataaatac cttaaaaata     3420

atagattgat gattttcttt atttcctaga gaatttattt tataaatact ttgtttacat     3480

tttagattgt acttgtcttt atttaaaatg atgaatctag tctgaatcag ctgttattcc     3540

aagctatcat gcttaagcta tgtcaacagc atttatttgt actaatgcta atatttccat     3600

caaaatttgc ctgtggaata tatacagttc ttaattttaa actgtcagtt cttgagatat     3660

accgtgtgaa gctattgtca gcttctctat ttcaaaatgc aatcagcata taactatatt     3720

gatattagaa gatatttgtt ttttaaaata tattgatgta tgataaagat gatctaattt     3780

gtgaatgcat atgtatgtgt ggttactttt tataatgtga aataatgaat aatgaattta     3840

ctcaaaataa aacataggtt aatgagat                                        3868


<210> 726
<211> 1169
<212> DNA
<213> Homo sapiens

<400> 726
catttgggca acggacgaat taagcggcgt ggagatgcgg cagccactga gctggggccg       60

ctggcgcgcg atgcttgccc gaacctacgg ccccgggcct tcggcgggtt accgctgggc      120

ctcgggcgca cagggttacg tgcggaatcc gccagttgga gcgtgcgatc tgcagggcga      180

gctggacaga ttcgggggca tctcggtgcg cctggcgcgg ctcgatgcgc tggaccgcct      240

ggacgctgcc gccttccaga agggcttgca ggctgcagta cagcaatggc gatcagaagg      300

tagaacagct gtatggctgc acattcccat cctccaaagc cgatttattg cccctgctgc      360

ttccctgggc ttctgctttc accacgcaga atcggattca tcaacgttga ctctgtggct      420

gagagaaggg cccagcagat taccaggata tgcttcacat caagtaggag ttgcaggagc      480

tgtatttgat gaaagtacta gaaaaatact ggttgtacaa gatcgaaata aattgaaaaa      540

tatgtggaag tttccaggag gcctgtcaga gcctgaagaa gatattggag acacagcggt      600

tcgagaagtt tttgaagaga ctggtataaa atcagaattc aggtccgtcc tgagtattcg      660

gcaacagcac acaaatcctg gagcttttgg gaagtcagat atgtatatca tctgccgcct      720

aaagccatat tcattcacca taaatttttg ccaggaagaa tgcttaagat gtgagtggat      780

ggatctcaat gacctggcga agactgaaaa tacaactccc atcaccagca gagttgctag      840

gctgctgctg tatgggtaca gagaagggtt tgacaaaatt gacctgactg tggaagaact      900

tccagcagtt tacacaggac tgttttataa actctatcat aaggaactgc cagagaatta      960

taaaactatg aaaggaattg attaaattca catttatatg tttagaaaca tgtagactaa     1020

cgaatgacat aagaaatagt ggacattttg gattgattaa acatctgact gtgattttct     1080

aatgtatatg atttccatga agaaattttg tttctaaaca tgcacatttt aaaagcctct     1140

tttcgaataa agcaaatgcg tgaaaaaga                                       1169


<210> 727
<211> 2081
<212> DNA
<213> Homo sapiens

<400> 727
gtgagccgag attgcaccac tgcactccag cctgggtgac agagcgagac tccatctaaa       60

aaaaataaat aaacatggga gaaacctgga agaatatttg ctcaactgtg aggcatggtt      120

ggtggctaag ggatcacaga atggcaggcc tgcctattcc tcctgagatc gttaaggagg      180

ctgaggtgcc gcaggctgcg ctgggcgtcc cagcccaggg gacaggggac aatggccaca      240

cgcctgtgga ggaggaggtc gggggcatcc cagtaccagc accggggctc ctgcaggtca      300

cggagaggag gcagcctctg agcagcgtct cctctctgga ggtccacttc gacctcctgg      360

acctcactga gctcaccgac atgtcggacc aggagctggc cgaggtcttt gctgactcgg      420

acgacgagaa cctcaacacc gagtccccag caggtctgca cccgctgccc cgggccggct      480

acctgcgctc cccttcctgg acgaggacaa gggctgagca gagccacgag aagcagcccc      540

taggcgaccc cgagcggcag gccacagtcc tggacacgtt tctcactgtg gagaggcccc      600

aggaggacta gaccatctcc acctgcccca gctcctgcag ggatggggtc cgaacacgat      660

ggcagatctg ggcagtgctg acccagcaga cacacttcac ccgcccacga ggctccagcc      720

gtcacctcct gacacacacc ctgggggcag ctctctgcca gccccgagac cggccttgtc      780

tgctgggcac gggtcttcgc ctcacttgga gaccagccgg ctttcctggg ggacacacgg      840

ggcccccgga tgcctctggg agccccagca caagcacagc ccagtggcct tacgtccagc      900

tcgttcctgg gccccgagtc aggaagacag cgtcacggag tcactgccag gaacgtgctg      960

aggaatggag tggcccacgg cggccttggg gtgaagggga cccaggcctg tgacagccac     1020

tccaggaact cctgggggtg ctccaacctc cgcgttttcc tgtgctgcca agctcagaag     1080

ccagaggcgg gtttggtagt ggctaatggg acaatgtgct gtccagcaaa gcacacatgg     1140

agaagcggcc ccaaaattcc caccttgatt tccatcctgc cccttcttct actccacgga     1200

ggcgctgtct cactagggtc ccctccccaa ggctcagctc taagacctgc acctgcttct     1260

cttggcccct gcgtgacaga caagtccatt ccctccttag ctcagaacac caaatatcac     1320

cagactgcct aagagacttg atgacacctc ccggaatgct ctcggggtgg ggttcacctc     1380

tccttgtcct gcacccactg ctaggccaca ttctcgtttc tgctcacatc ccattgcccg     1440

gctacaaggc ctgcccacgg cccttaaact tgctgggcag gtttggagcc catgggaccc     1500

cgtgggtctc tgtccaggag cagcagagga ggctgacagg ccctgctccc tctgctctgg     1560

gggtgtctgg gagccccagc tcacaccctc ccaatgctta tatgctgaag ctcacagaat     1620

gggcttcttg cctgacagca agtcaaagaa tgagtttaat atcaaagtgt aagcttactt     1680

tccatcccca agccagcctg ccccctgccc catttcccat gagcacactt ctggggaagg     1740

aaaacaggct cctggccttc actctcagca gagctttgga gatgccccag gcatgccctg     1800

agctccttct gtgtacctgc tcccacttct gagccacccg ctgcccctcc gcactgctgg     1860

caaacccagt tcctgcctca gccaggtctc cttccctggt ttccagtcac acagagccca     1920

gcagctttct ctttcagtcc cataagggca gccttgtgtc cctggccaca cttccacccg     1980

ccagggtctt cctccccatc tttccatcct tcctgctgag cttccacaga gctcgtttgc     2040

aaacaggggg attaaagcat cactgcgcat tcgaaggcct g                         2081


<210> 728
<211> 3769
<212> DNA
<213> Homo sapiens

<400> 728
gtgatgaaac tgtaacttac aagaaaaggg ctgggttttg aaaataacac aggctctaaa       60

aaccctaaga agcggtgcaa cttttggcag gaatcggggt tagcgggacc tcaagggctc      120

actgcggcta agtgaacgct gactggtcct ccagcgtgag ctagaacaga cgtctctatg      180

gtcaagtaaa cagagcgtgt gctgtcttcc ccatgtggtg gggttgcgca tgatcagtag      240

ctgcaccact agaaagatgg cggagcaaga gcaaagaaaa atccctttgg ttccagaaaa      300

tctcctgaaa aagaggaagg cttatcaagc cctcaaagcc acccaggcaa agcaggcact      360

tttggcaaag aaggagcaga agaaaggaaa agggctcagg tttaagcgac tggaatcatt      420

cctacatgat tcctggcggc agaaacgtga caaggtgcgt ctcagacgac tagaagtgaa      480

acctcatgcc ttggaattgc cagataaaca ttccttggcc tttgttgtac gcatcgaaag      540

gattgacggc gtgagtttac tggtgcagag aaccattgca agacttcgcc taaagaaaat      600

ttttagtggt gtctttgtaa aagtcacccc ccagaatcta aaaatgctgc gtatagtgga      660

accttatgtg acctggggat ttccaaatct gaagtctgtc cgagaactca ttttgaaacg      720

tggacaagcc aaggtcaaga ataagaccat ccctctgaca gacaatacag tgattgagga      780

gcacctgggg aagtttggcg tcatttgctt ggaagacctc attcatgaaa ttgccttccc      840

agggaagcat ttccaggaga tctcatggtt cttgtgccct ttccacctct cagtggcccg      900

tcatgctacc aaaaatagag tgggcttcct caaggagatg ggcacacctg gctatcgggg      960

tgaacgcatc aatcagctca tccgtcagct gaactagacc caggtgccaa actgcggtaa     1020

attttttatc agtgaagtgg aagcatgtgt tttgttttgg aaatttttat caagtatctt     1080

cagagaagat tatttcctgc tttatcttca gaaactggaa agggtcaaag aaaagacagt     1140

agctggccgg tcgtggtggc tcatgcctgt aatcccaaca cttagggagg ctgaggtggg     1200

cagatcacct gaggttggga gttcgagacc agcctgacca acatggagaa atgccatctc     1260

tactaaaaat acaaaaatta gccgggcatg gtggcacgtg cctgtaatcc cagctactca     1320

ggaggctgag gcaggagaat cgcttgaacc tgggaggtgg aagttgcagt gagctgagat     1380

cacgccattg cactccagcc tgggcaacaa gcgaaactct gtctcaaaaa aaaagaaaag     1440

acagtagcat atgttcatgt caagcacctc tcatcacagt cgagttccaa ggaaaaattc     1500

cagtgttttc tgcattgggt gctgtgtcat ctgaaatcgg cacattccat ggaggaagga     1560

gtcctgcttt gttgcatgta tcctagggtt taatgttggt aaatgagtca ctctagcatt     1620

tgtagaaggc tccctgagac tcctgcagca gtcgaccaag cccaaggaca taattgaatc     1680

tggagagtcc tggggccttg ttttgaaaaa gacttgaaat acacatagga agaaaggcat     1740

aaaaataaat gttcacttgt ctctgctgtg agtatgtgtt ccaacttttc agtgatggct     1800

ttgagaattc tcaaacttga ctggctctaa gtgtatctgg tggcttttgt atcgtaacct     1860

gaaactggct tagtactttt tcctaaaagc tcaggatttg agaatgagga ccccttcgcc     1920

aggaaaacat gtatacactc aaaattttgc ttgcagttct agggtgttta gacccttctc     1980

agatacctgt gcatcttatg ggttttgttt ttctctttga gacagtctca ccctgttgcc     2040

caggctggag cgcagtggca tgatctcagc tcattgcagc ctccacctcc tgggttcaag     2100

tgattctgcc tcagcccctt gatcagctgg gattacatgc atgtaccacc acacccagct     2160

aattcttgta tttttagtag agatggagac agagtttcac catgtaggcc aggctagtct     2220

caaactcctg acctcaagtg atccacaagc ctgggcctcc caaagtgctg ggattacagg     2280

catgagcaac tgcgcccagc tcttgtgtac cttatgtgag gaagtcctgc tcaatcagga     2340

tcggtcacgc aggccctgat cttgctactc tggttccatg tcctatggaa gaccaaagtt     2400

taccaagata gatttttccc ttcatagtgg cagatagtgt taacccctgc accatctgta     2460

actcagaaat ccccaccatt tcttcccctg ggcttcagaa tagaattgcc tggtttctct     2520

gatgatcagc atggttcctt aaaacccaaa tcagcaagga atgaacaatt ttgtttggca     2580

tggatgaaat tagcactgtt tggctcgtta ggccccaggc aggcaggcac cttaattttt     2640

tccttgcata ttctagtctt cagaagcatt gccttttgtc ctactggtag tgacatagac     2700

caataacagg gcatctgggg attttaatcc tgaaaacagt gagtctgata ctgcttgtgt     2760

ttttcatcag tgtccacccc aagtgggtct tcctgctatt ctcttcactt agttgcccct     2820

cacttgccat ctgagcaatt ggcaaggatg tgccaggcct aggttaaact tggaaacatg     2880

cttgaccatt ctattccctg gtcctttaag atcagtttgg ctgcaatttt ggctccttgg     2940

accctcaagc atagctggta aatcaagtta gagatgtaac tgccttaaaa catgccagct     3000

taggctgggc acggtggctc acacctgtaa tctcaacact tcaggaggct gaggcaggca     3060

gatcacttga ggtcaggagt tcgagaccag cctgaccaac atggagaaat tctgtcccta     3120

ctgaaaatac aaaattagcc ggatgtggtg gtgcatgcct gtaatcccag ctacttggga     3180

ggctgaggca agagaattgc ttgaacccag ggaggcagag gttgcagtga gccgagatca     3240

caccattgca ctccaccttg ggcaacaaaa gcaaaactct gtctcaaaaa aaaaaaaaaa     3300

aaaagtgcca gcgtatgagg taattagatt ggttctctcc agaggtaacc tgccaagaag     3360

agatgctata gatgttactc ctatactgta aaacattgtg aaatcagatt actttaaaat     3420

gatgtattac aaagttatgc aaaaaagcag ttgtgactat ggaagcccaa ggcttatatc     3480

ccagctctgt cttacactaa atatgggtac agtgtttcca ctctgtccat aaaatgggag     3540

ctaatattct ccaacctgtg tgcctgacat gatggttaaa gggattaaac aaaacaatag     3600

tttgtaattt attctgtcag agcaaactgc tggtaaataa aagggactaa gttgacgaaa     3660

aataaatttt aaaaaaccta ataaaacaag tttgtaattt ataattgtat acaaataaaa     3720

gatgttacaa aaattgcgca cttatatgta tgtaccatga cataactaa                 3769


<210> 729
<211> 3334
<212> DNA
<213> Homo sapiens

<400> 729
agcactcttt cagtcagcat cgttcctgga tttttttctc actgctgagc agcataaaag       60

ggtggggccg cttccctgca gcagaggcag aggcggcggc ggcagcggct gcagcatcat      120

tcgcgggcag cggcggagac cgagagctgc agaaaagggt ggggtcgctt cccaggagaa      180

gaggcggtgg cggcggcggc tgcggcatcc tcgcgggcag cggcggaggc agcaatgctc      240

ggtctccgct ggaggtgatg gcctcccagc cctgctaggt ggccggctgc actaggacgc      300

cggcaggaag gagactcgag cccggtccgc ggaccctgcg gccacaccgc ccggcccctc      360

ctctgcgcca tggcttaagc ctgtagccac ctctcctcac gtcgcctcgc tcgaccgagg      420

tctgtgcgcc gccgcagccg cagggagggg cgcgtcccag acaccctcgc cggggactcg      480

ggaacgccgt gcgtctcacc cttcggcgct cgcagcagac tgcgctccca aaggcgtttg      540

cgaccggtaa tcgagggact ctacagactc tcctaggaca gctctccccg ggtgctcgct      600

gagggaggag ggcgaactag ctccggctga tcgggggtag aaaacggtgg gaaccacatt      660

ggccggtcag gatcggaggc tgaaggaaga ttatagagac ttgctttaga accacaagaa      720

gaaagaggag gccggctttt cagctagcat catggcgtgg ccgtgcatca cgagggcctg      780

ctgcatcgcc cgcttctgga accagttgga caaagcggac atcgctgtgc cgctggtttt      840

caccaagtac tcggaggcca ccgagcaccc gggcgccccg ccgcagccac cgccgccgca      900

gcagcaggcg cagccggcgc tcgcgccccc ctcggcgcgc gcggttgcca tagagacgca      960

gccagcccag ggcgagttgg atgcagttgc ccgggcaacg gggccagcgc ctgggcctac     1020

cggcgagcgc gagccggcgg cgggccccgg ccggagcggg ccgggcccgg gcctgggctc     1080

cggctccacc tccggccccg cggactcggt gatgcggcag gattaccgag cctggaaggt     1140

gcagcggccc gagcccagct gccggccgcg cagcgaatac cagccctccg acgctccctt     1200

cgagcgcgag acccagtacc agaaggactt ccgcgcctgg ccgctgccgc gccgcgggga     1260

ccacccgtgg atccccaagc ccgtgcagat ctctgcggcc tcccaggcgt cggcgcccat     1320

tctcggggcg cccaagcgcc ggccgcagag ccaggagcgc tggccagtgc aggccgccgc     1380

tgaggcccgg gagcaggagg cggcccccgg cggagcgggt ggcctggcgg ccggaaaggc     1440

gtccggggcg gacgagcgcg acacgcgcag gaaggccggg cctgcctgga ttgtgcgccg     1500

cgccgagggc ctggggcacg agcagacgcc gctgcccgcg gcccaggccc aggtccaggc     1560

caccggcccc gaggctggca gggggcgcgc cgcggcggac gccctcaacc ggcaaatccg     1620

cgaggaggtg gcgagtgcag tgagcagctc ctacaggaat gaattcaggg catggacgga     1680

catcaagcct gtgaaaccaa taaaggccaa gccccagtac aagcccccag atgataagat     1740

ggttcatgag accagctaca gtgctcagtt caaaggagag gccagcaagc caacaacagc     1800

tgacaataag gtcattgatc gcagaagaat acgcagcctc tacagcgaac ccttcaagga     1860

acccccaaag gtggaaaaac ctagtgttca gagttccaaa ccaaaaaaga cctcagcgag     1920

ccataagccc acgaggaagg ccaaagacaa gcaggcggtg tcaggccagg ctgccaagaa     1980

aaagagcgcg gagggcccga gtaccaccaa gccagacgac aaggagcaaa gcaaagagat     2040

gaacaataaa ctggctgagg cgaaagagag cctggctcaa cccgtcagtg attcaagtaa     2100

gactcaaggt cctgtagcca cagagccaga caaggatcaa ggttctgtgg tcccaggcct     2160

tctgaaaggt caaggtccta tggtgcaaga gcctctgaag aagcaaggtt ctgtggtccc     2220

agggcctcca aaggatctag gtcccatgat cccattacca gtcaaggatc aagatcacac     2280

ggtccctgag cctttaaaga atgaaagccc tgttatctca gcaccagtca aggaccaagg     2340

tccctcggtc ccagttcctc caaagaatca aagtcctatg gttccagcaa aagttaagga     2400

tcaaggctct gtggtaccag agtctctaaa ggatcaaggt cctaggattc ctgagcctgt     2460

gaagaatcaa gctcctatgg tcccagcacc tgtcaaggat gaaggtccca tggtctcagc     2520

atctgtcaag gatcaaggtc ccatggtctc agcacctgtc aaggatcaag gtcccatagt     2580

cccagcacct gtcaagggtg aaggtcccat agtcccagca cctgtcaagg atgaaggtcc     2640

catggtctca gcacctatca aggatcaaga tcccatggtc ccagagcatc cgaaggatga     2700

aagtgccatg gccacagcac ccataaagaa tcaaggttcc atggtctctg agcctgtaaa     2760

gaatcaaggt ttagtggtct cagggccagt caaggatcaa gatgttgtag tcccagagca     2820

tgcaaaggtt cacgattctg cagttgtggc acctgtaaag aatcaaggtc ctgtggtccc     2880

cgagtccgtg aagaatcaag accccattct cccagtacta gttaaggatc aaggccccac     2940

agtcctacag cctccaaaga atcaaggtcg tatagtccct gaacctctga agaatcaagt     3000

tcctatagtc ccagtgcctc tgaaggatca agatcctctg gtgccagtac cagcaaagga     3060

ccaaggtcct gcagtccctg aacctctgaa gactcaaggt cccagggacc ctcagctacc     3120

tactgtctca cctctacccc gagtcatgat cccaactgcc ccccatacgg aatacattga     3180

gagctcccct tgacactcac cccttgacac accaatgaag gagctgacag tgagagtgct     3240

cccctcccag gggcagtgaa gacacatatt taatctgcat gaaacatgta cagtagtctt     3300

gctggaatct aataaaaatg gtccctctgg ctca                                 3334


<210> 730
<211> 1480
<212> DNA
<213> Homo sapiens

<400> 730
gccatcttgg ggctgctggg actcgcgtcg gttggcgact cccggacgta ggtagtttgt       60

tgggccgggt tctgaggcct tgcttctctt tacttttcca ctctaggcca cgatgccgca      120

gtaccagacc tgggaggagt tcagccgcgc tgccgagaag ctttacctcg ctgaccctat      180

gaaggcacgt gtggttctca aatataggca ttctgatggg aacttgtgtg ttaaagtaac      240

agatgattta gtttgtttgg tgtataaaac agaccaagct caagatgtaa agaagattga      300

gaaattccac agtcaactaa tgcgacttat ggtagccaag gaagcccgca atgttaccat      360

ggaaactgag tgaatggttt gaaatgaaga ctttgtcgtg tacttaggaa gtaaatatct      420

tttgaattag agaaagtgtt gggacagaaa gtactttatg taactaagtg ggctgttcag      480

aagcttagag gtcatttttt gtaattttct ttttaattac tttagagagc tagggatgca      540

aatgttttca gttagaaagc ctttatttac ttttggaaat tgaacaagaa atgcatctgt      600

cttagaaact ggagattatt tgatgttagg taaaacatgt aattgtttct ctggcaaatt      660

tgtatcagta atttgaaaat gagatattag gaaaaaccaa ttcttcttaa atttagttca      720

tctttcttta aaagaacatt aaatgtaacc attttgtcag atccatgtat tttggagcat      780

aaaatgtatg ctgttgtgac caataaatat aaaatatggt aattggaatt aactccacac      840

catagtatgc attgttatac atactgtgta cctaattatg tatagcagtg tagtctcaat      900

tatatctgaa agtaattgtg actaacaagt atgctttgcc ttatttccac atttaaacta      960

cctgttaata taagggattt gtagtatcag cttgttgagc aatgactttg aatctagttt     1020

tcagtgatca gaagcagcag ttatttgagt gtatgaatgg aatgatgatc actgtgctat     1080

aatgtactga aaccaccata ttacagaaat atttactaca tattttccat ctgtagtttc     1140

tcagaagggc tatggattag tttgaactgt caaatccttg catacttctg tgacacccct     1200

gcccattttc tgtctttaat taaccaaggt gttaggtgtg actgtcacaa ctgttatgtt     1260

ttccagtaaa ctagaagtac gatatttgat aattatattt gtatttcacc acctaaatgt     1320

aatgttgatt cctcaagaat gaaatgaagg cactacattg aaatatgttt tgtataaatt     1380

tgtcatgttg aacagcattt tagcatggta agttccctta gctatatgaa ttttggcatg     1440

tttcagagag atcagtaaat aaaatattag ataaaatata                           1480


<210> 731
<211> 1444
<212> DNA
<213> Homo sapiens

<400> 731
aaccattgtg atggtctaga taagtgtaca tgcttaggcc ttctgaagca gcatttgaag       60

ctgcagtcct gaaaaccatg caggccggaa gagtagataa agaaatattt atttgagatg      120

gcacatgttt cttcagaaac tcaagatgtt tcccccaaag atgaattaac tgcttcagaa      180

gcctccacta ggtctccatt gtgtgaacac accttccctg gggactcaga cttacggtca      240

atgattgaag aacatgcttt tcaggttttg tcacaaggat ccttgttaga aagtccaagt      300

tacacagttt gtgtctctga gccagataaa gatgatgatt ttctttctct gaactttccc      360

aggaaacttt ggaaaatagt ggaaagtgac caattcaagt ctatttcatg ggatgagaat      420

ggaacttgca tagtgattaa tgaagaactc ttcaagaaag aaattttgga aacaaaggct      480

ccttacagaa tatttcaaac tgatgctatc aaaagttttg ttcgacagct caacctttat      540

ggatttagta aaattcaaca gaattttcaa agatctgcct ttctagccac ctttctgtca      600

gaagagaaag aatcgtctgt cttaagcaag ttaaagttct attataatcc aaatttcaag      660

cgtggctatc cccaactttt agtaagagtg aagagaagaa ttggtgttaa aaatgcttca      720

cctatatcta ctttattcaa cgaagatttc aacaagaagc attttagagc aggggctaac      780

atggagaatc ataattctgc cttagctgct gaagctagtg aagaaagttt attttcagcc      840

tctaaaaatt taaatatgcc tctaacaagg gaatcttctg tcagacagat aattgcaaat      900

tcatctgtcc ccattagaag tggtttccct cctccttcac cttcaacctc agttggacca      960

tcagaacaaa ttgcaacaga tcaacatgct attttaaatc agttgaccac tattcatatg     1020

cactctcata gtacctacat gcaagcaagg ggccacattg tgaattttat tacaaccaca     1080

acttctcaat accacatcat atctccctta caaaatggtt attttgggct gacagtggaa     1140

ccatctgctg ttcccacacg atatcctctg gtatcagtca atgaggctcc atatcgtaac     1200

atgctaccag caggcaaccc gtggttgcaa atgcctacga tcgctgatag atcagctgcc     1260

cctcattcca ggctagctct tcaaccatca ccactggaca aatatcaccc taattacaac     1320

tgatctgcca ttaaaagagg accagattat gaatgacaac agagactaac atttacattg     1380

acaaaaaacc ctaaaaattt ctgcaattat cttattgaac aataaaattg catgtttact     1440

tcta                                                                  1444


<210> 732
<211> 5718
<212> DNA
<213> Homo sapiens

<400> 732
accgcaaaga agtcgcgctt tgattgggcc gctgtcaggt gtcgctgcct gcaggttcgg       60

ctgcgcgagc ggagggaggc gggactcaag agtagccttc ctcgaggacc tgcctttccc      120

atttgctgcc tgaagttaat gtttcttgct ggccaaatca gggacatgcc ggcattagcg      180

ggatgagtgg gtgttccggc agggatgtgg tcattgacgg ccagtgaggg cgagagtacc      240

acggcccact tcttccttgg agctggagat gaggggctgg gcacccgtgg aataggcatg      300

aggccagaag agagtgacag cgagctcctt gaggatgagg aggatgaagt gcctcctgaa      360

cctcagatca ttgttggcat ctgtgccatg accaagaaat ccaagtccaa gccaatgact      420

caaatcctag agcgactctg cagatttgac tacctgactg ttgtcattct gggagaagat      480

gtaatcctta atgaacctgt ggaaaactgg ccatcctgcc actgcctcat ctctttccac      540

tccaaaggct ttcctctgga caaagctgtt gcttactcca agcttcgaaa cccctttctt      600

atcaatgatc tggccatgca gtattacatc caagatagga gggaggtgta ccggatcctg      660

caggaagagg gtattgatct gcctcgatat gctgtgctca accgtgatcc tgcccggcct      720

gaggaatgca acctgataga aggtgaagac caagtagagg tcaatggagc tgtctttccc      780

aagccctttg tggagaagcc agtgagtgca gaagaccaca atgtttacat ctactacccc      840

agctcagctg gaggaggaag ccagcgtctc tttcgtaaga ttggcagccg aagcagtgtt      900

tactctcctg agagcagcgt ccgaaagacg gggtcgtaca tctatgagga gtttatgcca      960

acagatggca cagatgtcaa ggtgtataca gtggggccag attatgccca tgctgaagct     1020

agaaaatctc cagctttgga tgggaaggtt gaacgagaca gtgaggggaa agagattcga     1080

tatccagtca tgctgactgc catggaaaag ctggtggcca ggaaagtctg cgtagctttc     1140

aagcaaacag tttgtggatt tgaccttctt cgtgccaatg gtcattcctt tgtgtgtgat     1200

gtcaatggct ttagttttgt caagaactcg atgaaatact acgatgactg tgccaagatt     1260

ctggggaaca ccataatgcg ggagcttgcc ccacagttcc agattccatg gtccatcccc     1320

acggaggctg aggacattcc cattgttccc accacatctg gcactatgat ggaacttcgt     1380

tgtgtcattg caattattcg tcatggggat cgtactccca agcagaagat gaagatggaa     1440

gtgaaacacc caaggttttt tgctctgttt gaaaaacatg gtggctacaa gacagggaaa     1500

ttaaaactca agcgacctga gcagctccag gaggtgctgg atatcacaag gctgttgttg     1560

gctgaactgg agaaagaacc aggtggtgag atcgaggaga agactggaaa actagagcag     1620

ctgaagtctg tactggagat gtatggtcac ttctcaggta taaaccggaa ggtacaattg     1680

acttactacc ctcatggagt aaaagcttct aatgaggggc aagatccaca gagggaaact     1740

ctggccccat ctctgttgct ggtactgaag tggggtggag aactgactcc tgctggccgt     1800

gttcaggctg aggagctggg gcgagctttt cgctgcatgt accctggagg acagggtgac     1860

tatgctggct tccctggttg tgggctgctt cgtctccata gcactttccg ccacgatctc     1920

aagatctatg cctctgatga gggtcgtgtt cagatgactg ctgctgcctt cgccaagggc     1980

cttctggctc tagaagggga gctgacaccc attttggtgc aaatggtgaa gagtgccaac     2040

atgaatgggc tactggacag cgatggggat tccttgagca gctgccagca ccgggtgaag     2100

gctcggctgc accatattct acagcaggat gcgccctttg gccctgagga ctacgatcag     2160

ctggctccca ccagaagtac ttccctgctc aactccatga ctatcatcca gaatcctgtg     2220

aaggtctgtg atcaggtatt tgccctgatc gaaaacctca cccaccagat ccgggaacga     2280

atgcaggacc ccaggtctgt agacctgcag ctctaccaca gtgagacact agagctaatg     2340

ctacagcgtt ggagcaagct ggagcgtgac tttcgacaga agagtgggcg ctatgatatc     2400

agtaagatcc ctgacatcta tgactgtgtc aagtatgatg tgcagcacaa tgggagtctg     2460

ggacttcaag gcacagcaga gttgctccgt ctctctaagg cactggctga tgtggtcatt     2520

ccccaggagt acgggatcag tcgggaggag aaactggaaa ttgctgtggg cttctgtctt     2580

ccactgttgc ggaagatact acttgacctg cagagaaccc acgaggatga gtctgtcaac     2640

aagctgcatc ccctctgtta tctcaggtac tcccgaggcg tgctctcccc aggtcgccac     2700

gttcgaacgc gtctctattt caccagtgag agccatgtcc actccctgct cagtgtcttc     2760

cgttatggag gacttcttga tgagacccag gatgcacaat ggcagcgagc tttggattat     2820

cttagtgcca tctcagagct taactacatg acccagattg tcatcatgct ttatgaggac     2880

aacacacagg atcccttatc agaggaacgg ttccatgtgg agctacactt cagccccgga     2940

gtgaaaggtg ttgaggaaga aggcagtgcc ccggctggct gtggattccg tccagcctct     3000

tctgagaatg aggagatgaa aaccaaccaa ggcagtatgg agaacctgtg tccaggaaag     3060

gcatcagatg aaccagaccg ggcattgcag acttcacccc agcctcctga gggccctggc     3120

cttccgagga gatcacccct cattcgtaac cgaaaagctg gttccatgga ggtactttct     3180

gagacttcat cctcgaggcc tggtggctac cggctctttt catcttcacg gccacccaca     3240

gaaatgaagc agagtggcct aggctcacag tgcacagggc tgttcagcac cacagtgctg     3300

ggtggctcct ccagtgcccc gaatcttcag gactacgccc gcagccatgg caaaaagcta     3360

ccacctgcca gtctgaagca ccgagatgag ctcttgtttg tcccggccgt aaaacgattt     3420

tctgtgtcgt ttgcaaagca tccgactaac gggtttgaag ggtgttccat ggtgcctacc     3480

atctaccctc tggaaacact gcataatgcc ctttccctac gtcaagtgag tgaattcttg     3540

agtagagtct gccagcgcca cactgatgcc caggcacagg catctgcagc cctctttgat     3600

tccatgcaca gcagccaggc ctcagataac ccattttctc caccacgtac tcttcattca     3660

cctcccctgc aactccagca gcgctctgag aagccccctt ggtacagcag tggcccttct     3720

agcactgtgt ccagtgctgg tccttcttcc cctactacag tagatggtaa ctcccaattt     3780

ggcttcagtg atcaaccctc cctaaattca cacgtggctg aagaacatca aggccttggg     3840

ctgctccagg agacccctgg gagtggagca caagagctct ccatagaagg ggagcaagag     3900

ctttttgaac caaatcagtc cccacaggtg ccacctatgg aaaccagcca gccatacgag     3960

gaggtcagcc agccatgtca ggaggtccct gacatcagcc agccatgcca ggacatttct     4020

gaggcgctca gccagccatg tcagaaggtc cctgacatca gccagcaatg ccaggagaac     4080

catgacaatg gtaaccacac atgccaggag gtccctcaca tcagccagcc atgccagaag     4140

tccagccaac tgtgccagaa agtctctgag gaagtttgcc agctatgtct ggagaactcc     4200

gaggaggtca gccagccatg ccagggggtc tctgtggagg ttggcaagct ggtccataag     4260

ttccatgtag gggttggtag cttggtccag gaaacccttg tagaagttgg cagcccagct     4320

gaagagatcc ctgaggaggt catccagcca taccaggagt tctctgtgga ggttggcagg     4380

ctggcccagg agacttctgc gatcaatctg ttatctcagg gcatccctga gattgataaa     4440

ccatcccaag agttccctga ggagattgat ctgcaggccc aggaggtccc tgaggagata     4500

aattagaagt cctgggtggt ccctgaagtg attgatcagc tgcctggaga gggtattcct     4560

caagcccagc atccatctgg tgatccaaac cctcagagcc agtctctagc ccatgaccag     4620

cactcacccc ttccaccagc aacatgtgat taattttctc attagtggta tcacactata     4680

ccagccattt gagccagcaa ccttttctgt tggctaactc actggccagc tctcaccagc     4740

ggtgtctggg gaagtagttc tctttgtatg aagcatacct gtgccagagc tgtggttgag     4800

gaggagccag ttttaggttc gaagaagcca ttggctcctc acttagccat tagacttgaa     4860

taggatttcc ttggggtggg ttggtctgtc attacccagc cttctctgag catcctagga     4920

aatcacagat tgttaaagga aatgccgctt cactgctgaa gacaccatct ggcgacagca     4980

aatgcaaaag aggggactct agggtcttca cttttctggg gaaatgttca cgacttctca     5040

aggtacgctt agaccatatg tgcattcagg ggactcttgt ctttgccagc actcctcagg     5100

tgagcccggg atggctatct gaaatgtctg gaaaatagag tcccttcccc aaacatctga     5160

catggccact aaatctttag acttgcctta tagatccttc catatcatcc ccaagtgccc     5220

cttctgcctc agtcctgttc ctctgggcaa tagctctagg gaaaagtagg tattagactg     5280

ctgtgcaaaa ttcagagcaa ctacttaaaa tgctctagag gattcttagc cagtctgtga     5340

aagtgggcct cctctgtggt ggggctgttt ggcttaggag atgctgtagt agtagagata     5400

atcaggttct attttaagca atcagcagag atcaatattg tacagataca agcaaaggtt     5460

taataaatat atatatatat atttatttct gtagttgtgc cagggacaga ctggccaaag     5520

accaaacact gcagggtccc caagaaattt gtccttatat cattgtgtct gagggccaga     5580

tatgattatg aagctttttc caaagatcca gggatgggaa tgggagtggg taggaggggt     5640

aatgcggtca ttggagtcgg gggctggaac attatgagtg ctcaataaat ataaactaat     5700

gagaatggtg gtgatgga                                                   5718


<210> 733
<211> 3715
<212> DNA
<213> Homo sapiens

<400> 733
attctatgag acagagtctc actctgtcgc ccacgctgga gtacagtggt gcaatcttgg       60

cttactgcaa cctccgtctc ctgggttcaa gcaattcttc tgcctcagct tccggagtag      120

ctggaacgtg tgagccacca cccctggcta atttttgtat ttttagtaga gacaggctgg      180

tctcgaactc ctgacttccg gtgatctgcc cacctcagcc tcccaaattg ttggtattac      240

aggcgtgagc caccgcacct ggcctctatt tatttattta ttttgagatg gggtcttgat      300

atgaattcct agactcatgc ttctcatgct tgctaccacc cagtcctgcc tcctgcacag      360

cagtttccac taaagtcacc cctttacgag aggcatcttt tttttttttt tgagatggtg      420

tctcactctg tcgcccaggc tggagtgcaa tggcatgatc tcagctcact gcaagctcca      480

cctcctgggt tcaagtgatt ctcctgcttc agcctcccga gtagctggga ctacaggcac      540

ccgccaccat tcccggctaa ttttttgtat ctttagtaga gacggggttt caccatgtta      600

gccaggatgg tctcgatctc ctgacttcgt gatccacccg cctcggcctc ccaaagtgtt      660

gggattacag gcatgagcca ctgtacctgg cctactagag gcatcttaaa acacatctcc      720

tgtgtctcca ttccaaagcg catctttgtc tacactcctg gggtcctccc acgtcagcct      780

cccaaagtgc tgggattaca gtcatgagcc actgtgcccg gccccaccaa attgttttct      840

aacctgcttt tttcttgagg aatcttctgc agcacatgac tcacatgtag agccccttgt      900

ttcttgaggc cttcataccc gtcagctcat ctaaaagtca ctcctgagga gtaagggcaa      960

ggggcattgg gagaggtcag gcagccctgg gaagcctccc agcgtgtgtc ccaggaggcc     1020

tgctgcctgc agacactgct cccagacgca gcggcctcgg ccatcagagc gtgtcccacg     1080

atgaggtggc aacttccctg aagggcttgc tctcacccag gggtgtggtt ctccgtgtgc     1140

acacagatag atagttctac gtttgccata taccatttat atgcctcaca cagattaacc     1200

cactttcatt tcaaaaagac ctcctgtcat cgtgcccatt gtacagatga ggacactgag     1260

acacggaatc ctagtgacct gtgcaaggtc acacagctgg gaagggtgag ggaagcgtct     1320

gtgaacccag caggcccagc ccctgagtct aggctccgct cggcagctgt catgggagca     1380

gagtccgaga agcactgcag gcacctgctc tagggggaga gaggtggagg tggcaggtag     1440

agagaggacg acccctggga gctgagacga tgccagcctc acacggacag gctgggtgac     1500

ctcaggcaag tcgcttccca tttgggaccc caaggaccct tctgcagacc cagctggggg     1560

tccccgatga gactggctct cagagtccct gtgagtcccg tcagctgagg ccagtaatgt     1620

cctggcacca tcactggaca tggtttgctc tcccatggag gggcaggtgt agcagccaaa     1680

agcgatcctg agctctgggc ctctgaaccc tgctctgcca gctactgtgg gtgtctctac     1740

ccgctctgtg tctcagttcc ctttcctgaa aagaggggat agtaaaaact aaccctcaag     1800

gtgtttatta ccaatgccct tcatggagga atccgctgct ccaggccctt gccagcagct     1860

gcacagctgg gcctggggac ctgggtgtgg gtctgttgaa ccttggccca ccctggggct     1920

gtggtcggcc tggacgtgta ggtgtggagg tgcatattta ttatggcaat tttctgacag     1980

gtaacagagt gtggggctct cttctgaatg gggctcgtgg aggccgtggg tcaaaagccc     2040

taattttgta gtgagggcta aaaggcttca caagggaaag ggcctggctg gggctatggg     2100

ccggtgccga ccccccctct cccactttgt ttgcagttct gggaagtcat cagtgatgag     2160

catggcatcg accccagcgg caactacgtg ggcgactcgg acttgcagct ggagcggatc     2220

agcgtctact acaacgaggc ctcttctcac aagtacgtgc ctcgagccat tctggtggac     2280

ctggaacccg gaaccatgga cagtgtccgc tcaggggcct ttggacatct cttcaggcct     2340

gacaatttca tctttggtca gagtggggcc ggcaacaact gggccaaggg tcactacacg     2400

gagggggcgg agctggtgga ttcggtcctg gatgtggtgc ggaaggagtg tgaaaactgc     2460

gactgcctgc agggcttcca gctgacccac tcgctggggg gcggcacggg ctccggcatg     2520

ggcacgttgc tcatcagcaa ggtgcgtgag gagtatcccg accgcatcat gaacaccttc     2580

agcgtcgtgc cctcacccaa ggtgtcagac acggtggtgg agccctacaa cgccacgctg     2640

tccatccacc agctggtgga gaacacggat gagacctact gcatcgacaa cgaggcgctc     2700

tacgacatct gcttccgcac cctcaagctg gccacgccca cctacgggga cctcaaccac     2760

ctggtatcgg ccaccatgag cggagtcacc acctccttgc gcttcccggg ccagctcaac     2820

gctgacctgc gcaagctggc cgtcaacatg gtgcccttcc cgcgcctgca cttcttcatg     2880

cccggcttcg cccccctcac agcccggggc agccagcagt accgggccct gaccgtgccc     2940

gagctcaccc agcagatgtt cgatgccaag aacatgatgg ccgcctgcga cccgcgccac     3000

ggccgctacc tgacggtggc caccgtgttc cggggccgca tgtccatgaa ggaggtggac     3060

gagcagatgc tggccatcca gagcaagaac agcagctact tcgtggagtg gatccccaac     3120

aacgtgaagg tggccgtgtg tgacatcccg ccccgcggcc tcaagatgtc ctccaccttc     3180

atcgggaaca gcacggccat ccaggagctg ttcaagcgca tctccgagca gttcacggcc     3240

atgttccggc gcaaggcctt cctgcactgg tacacgggcg agggcatgga cgagatggag     3300

ttcaccgagg ccgagagcaa catgaacgac ctggtgtccg agtaccagca gtaccaggac     3360

gccacggccg aggaagaggg cgagatgtac gaagacgacg aggaggagtc ggaggcccag     3420

ggccccaagt gaagctgctc gcagctggag tgagaggcag gtggcggccg gggccgaagc     3480

cagcagtgtc taaacccccg gagccatctt gctgccgaca ccctgctttc ccctcgccct     3540

agggctccct tgccgccctc ctgcagtatt tatggcctcg tcctccccac ctaggccacg     3600

tgtgagctgc tcctgtctct gtcttattgc agctccaggc ctgacgtttt acggttttgt     3660

tttttactgg tttgtgttta tattttcggg gatacttaat aaatctattg ctgtc          3715


<210> 734
<211> 1614
<212> DNA
<213> Homo sapiens

<400> 734
gcggcggcgg cgggcgcggc gcgatgtgcg agcgggcggc gcgcctgtgc agggccggcg       60

cgcacaggct gctccgggag ccgccgcagc agggccgggc gctgggcggg ctgctgcgct      120

gggtgggcgc caggatgggc gagccccggg agtcgctggc ccccgccgcc cccgcggacc      180

ccggcccagc ctcgccgcgc gggggcaccg ccgtcatcct ggacattttc cgccgtgcgg      240

acaaaaatga tgatgggaag ctgtccttgg aggaattcca gctcttcttt gcagatggcg      300

tccttaatga gaaagaactg gaggatctct ttcacacgat tgactctgac aacaccaacc      360

atgtggacac caaggagctg tgtgattact ttgtggacca catgggtgac tatgaggatg      420

tcctggcctc cctggagacc ttgaatcact ctgtcctgaa ggccatgggt tataccaaga      480

aggtatatga gggtgggagc aacgtggacc agtttgtgac ccgcttcctc ctgaaggaga      540

cggccaatca gatccagtcg ctgctgagct cagtggagag tgcggtggag gccatcgagg      600

aacagaccag ccagctccga cagaaccaca tcaaacccag ccacagcgcg gcacagacct      660

ggtgtggaag ccccactccc gcctctgccc ccaaccacaa gctcatggct atggaacaag      720

gcaagaccct tccatctgcc acggaggatg caaaggaaga gggtctggaa gcccagatca      780

gccgcttggc agagctgatt gggaggctgg agagcaaagc actgtggttc gacctgcagc      840

agcgcctgtc agatgaagat ggcaccaaca tgcacctgca gctggtccgg caggagatgg      900

ccgtgtgccc cgagcaactg agcgagtttc tggactctct gcgccagtat ctgcggggga      960

ccactggcgt gaggaactgc ttccacatca ctgccgtgag gctctcagat ggcttcacct     1020

ttgtcatcta tgagttctgg gagacagagg aggcgtggaa gaggcacctg cagagccccc     1080

tgtgtaaggc gttccggcac gtcaaggtgg acacactgag ccagcctgag gccctctcca     1140

ggatcttggt gccagctgct tggtgcacgg tgggacggga ctgacagcct cccagaggcc     1200

cgtggaggag cccaccagcc ccttcttctt gtgaaggaaa tcccgttttt ttctagacag     1260

acactttggt gcagaagctt cttttcaatc catcctccac aagaaggtgt ttccctgttg     1320

ttaagtgaag gaggccgccc ctgcccccac ctgagaaggc agagcagtgt ctgtgctgcc     1380

aggtcctggt gaagcccaag gttgaagggg gcggcttcct ggagccagca cccctgcctc     1440

ctggtcctgg cctctcccct acccctcaca tggccacgca tgacccacac tgaccacacc     1500

ctgccctctt cggtgacatt cttctaccta gtaggagtca tgcccctgta gtgcccaacc     1560

tagccaggta gccaccactg tgcccaggcg ccaaataaac cctggttggg aaga           1614


<210> 735
<211> 4229
<212> DNA
<213> Homo sapiens

<400> 735
cactcgggtc gcgggcgttg gcagccgggc gggtgggagg ggccggagca aaagttccgg       60

gcgcccgagc cggctgctcg tgccatggag cggagtcccg acgtgtcccc cgggccttcc      120

cgctccttca aggaggagtt gctctgcgcc gtctgctacg accccttccg cgacgcagtc      180

actctgcgct gcggccacaa cttctgccgc gggtgcgtga gccgctgctg ggaggtgcag      240

gtgtcgccca cctgcccagt gtgcaaagac cgcgcgtcac ccgccgacct gcgcaccaac      300

cacaccctca acaacctggt ggagaagctg ctgcgcgagg aggccgaggg cgcgcgctgg      360

accagctacc gcttctcgcg tgtctgccgc ctgcaccgcg gacagctcag cctcttctgc      420

ctcgaggaca aggagctgct gtgctgctcc tgccaggccg acccccgaca ccaggggcac      480

cgcgtgcagc cggtgaagga cactgcccac gactttcggg ccaagtgcag gaacatggag      540

catgcactgc gggagaaggc caaggccttc tgggccatgc ggcgctccta tgaggccatc      600

gccaagcaca atcaggtgga ggctgcatgg ctggaaggcc ggatccggca ggagtttgat      660

aagcttcgcg agttcttgag agtggaggag caggccattc tggatgccat ggccgaggag      720

acaaggcaga agcaacttct ggccgacgag aagatgaagc agctcacaga ggagacggag      780

gtgctggcac atgagatcga gcggctgcag atggagatga aggaggacga cgtttctttt      840

ctcatgaaac acaagagccg aaaacgccga ctcttctgca ccatggagcc agagccagtc      900

cagcccggca tgcttatcga tgtctgcaag tacctgggct ccctgcagta ccgcgtctgg      960

aagaagatgc ttgcatctgt ggaatctgta cccttcagct ttgaccccaa caccgcagct     1020

ggctggctct ccgtgtctga cgacctcacc agcgtcacca accatggcta ccgcgtgcag     1080

gtggagaacc cggaacgctt ctcctcggcg ccctgcctgc tgggctcccg tgtcttctca     1140

cagggctcgc acgcctggga ggtggccctt ggggggctgc agagctggag ggtgggcgtg     1200

gtacgtgtgc gccaggactc gggcgctgag ggccactcac acagctgcta ccacgacaca     1260

cgctcgggct tctggtatgt ctgccgcacg cagggcgtgg agggggacca ctgcgtgacc     1320

tcggacccag ccacgtcgcc cctggtcctg gccatcccac gccgcctgcg tgtggagctg     1380

gagtgtgagg agggcgagct gtctttctat gacgcggagc gccactgcca cctgtacacc     1440

ttccacgccc gctttgggga ggttcgcccc tacttctacc tggggggtgc acggggcgcc     1500

gggcctccag agcctttgcg catctgcccc ttgcacatca gtgtcaagga agaactggat     1560

ggctgagctg gcccggggct gccccggtct tgtgccacag cactgttttc tttctgccct     1620

cttcctaatg cccacactgc ttgggcacta ttgcgcccct gcctccttgc caggctcttc     1680

ctcctgtcct gcctggtcct tttccatgac tccaggctgt gcctctctcc atgtttggtc     1740

ccttctgtgc ccatggtcag gagctattcg ggtggcacct cgctggccag gctctcccga     1800

gtcgtggcac ctccacaatg tgaattttct gaatccctat tccaggattt ctgggaataa     1860

tgtttacttc tagaatgggc ctgttgtaaa ccatctcatc gaggtgtggt aaagccattg     1920

gatgaggagg ggactgccat ggaaaggaga gtttgttact tacggttctg agaggagggg     1980

ccacatagga aagccccacg gtgggtcaga aggcggaagg agggagggga acgtgtgggc     2040

aagagacttc ctctggtttc ctcaggagga aatgggcaag gcagagtaag caggggagac     2100

aggtttaagg gtagctggct tgagtaattt cagtggctct caggataggg gctgcccttt     2160

ttgtctgata cctggccccg ggatagtcag gacaggtgaa tgttggcctg gggtgtgaca     2220

gccctgggag agccatgtga aggaggcagc tggcgccatc gctccggatt agttggtttc     2280

cataggaaag gcatgctttc agccagatgc ttgccatctc tagggattgg gggattggct     2340

agcctgggag gatcagtctg tccaggtcag cgaggcccca gataccagag catcaagagt     2400

acaggaaata cagttaatgc agggcctctg tgtggctgga tcctccgtct ccatcagatc     2460

agctctgatt gatctattct tgcacgattt cctctgaaca cagggttcca gagtacttaa     2520

acacaacatt ttttaaatcg tgatttcggc ctatttcctt gccaggcctg tttccccacc     2580

aggaaatgag ataggaggac tggatgagga tgtcctgtta tagttgctgt ggaggaagtt     2640

cctctggtta attctcatca gcgtctgcag aaaagaagga aagagggcac ccttttcagt     2700

tgggaagaaa ggagaggggt ggcgccatgg acgtggccct aaacgctgtg ggagagggaa     2760

gaggaggctg ggcctcgctg ccctcttgtc tctgctgact tcagcctggt catgcttgct     2820

ctgccacttg cgatttcatc cctaatttct tcctccacca tgcctgcaga cttttccctg     2880

ggcttgtttt ttctcgcaca tctctgaaga gtttttaatc ttcagctcat catgtcccag     2940

gaagtggcat cataaaagga aatatttttt tttcctagga gcagtgttaa aatctgggtc     3000

acattcctga ccaaggacag catcctgcct tctgcccatc cccttcagtt cacaaaagct     3060

gacattttaa acaaatcatg actcacacgt attaattggt tataaatatg ttgtgtacac     3120

tggttagata aaacttaagg ccacaaggag ggcccaggta ggcgatgtca gtgtgtgaag     3180

gggctggatt gggcgtggtg aggatgttgg caaaccagtg catgcacctg gttggaagat     3240

gctcagcctc acaaaagctc caagcccttt gggagccaaa gtgtctgaga gtgtgaccct     3300

ctcctgtaaa gtatttatcc cacccattaa tataatttct gtataataaa cttgacctga     3360

aattatttca ttctttatat taaactttta aaaatgtttt ttattttcac cttagatatg     3420

ggaagagttt tttttttttt ttttttttta acaggataac ttgagcaggc taggcctctt     3480

aaaaaaaaat ttgagctaaa actcattttt cttttggcat tttcttttca atgttcttat     3540

aagcaaagtt catccatgtt gtagcatgtg ttcaacttta ttttttcatc gggtaatatt     3600

ccattgtatg gaatggtagt actacatttt atttatcatg catcgattgg tggacatttg     3660

gatcgtttct acttcttgac tattatacat aatgctgcta ggaacttttg tgtatgagtt     3720

tttgtgtgga catatgtttt catttctctt tggtatatgc ctgggagcag atttgctgga     3780

tcatatgaaa ctctatttaa cccttgaggg actcccaaac tgttttccaa tgtggtgaca     3840

caattttata tcccatcaac agggcatgag ggttctgatg actccacatc cctcagtgct     3900

ttttattatc tatcttttaa cttagccatc ctagtagggg taatgtggca tctcattgtg     3960

attttggttt gcatttccct gatggcgaat gatattgagc atcttttcat gagcttattg     4020

gccatttgca tatcttctta ggacagctat ctttagatca cttgctcatt ttttaattgg     4080

gttatttgtc tttttattat tgagttgtaa gagtcctttt atagcctggc acaagtccct     4140

ttaactggta tatgattata aaatttttct ccgtgagctg tttcatttcc ttgatgatgt     4200

cctttgaaat actaaagctt ttaattttg                                       4229


<210> 736
<211> 2570
<212> DNA
<213> Homo sapiens

<400> 736
cgcgcaatct gcttccggcc tgcgagctcg gtgttccgct ttttgtgggc cgggtgggtt       60

tcctaatctg gtttcgtctg cctggttcat ctgtgtgcga tggctccgga ctcggatccc      120

ttccctgaag ggccgctctt aaagctgcta cccttagacg ctagagaccg gggcacccag      180

cgctgccgcc tgggcccggc cgccctccac gccctgggcg cgcgcttggg ctcggcagtg      240

aagatctcgc tacccgacgg cggctcctgc ctctgcactg cctggcctcg gcgggacgga      300

gcggacggct ttgtgcagct ggacccgctg tgcgcgagcc ccggggcggc ggtcggggcg      360

tcgagatccc ggaggagtct cagcctgaat cgcctcctcc tagtgccctg tccgcccctg      420

cggcgcgtcg ccgtgtggcc ggtgttgcga gagcgggcag gcgcgcccgg tgcccggaat      480

acagccgcgg tgctggaggc ggcacaggag ctgctgagaa accgaccgat ctccctgggc      540

cacgtggtgg tcgctccgcc aggcgctcct ggcctggtgg ctgccttgca catcgtcggc      600

gggacgccca gtcccgatcc cgctgggctg gtcacccctc gtacccgcgt cagccttggc      660

ggggagcctc cgtcggaagc ccagccgcag cccgaggtgc ccctgggagg tctttcggag      720

gcggccgact cgctgcggga gctcctccgc ctcccgctcc gctacccgcg cgccctgacc      780

gcgctgggct tagcggtgcc tcgcggggtg ctcctggcgg ggccccccgg agtgggcaag      840

acccagctgg tgcgggccgt ggcgcgcgag gcgggcgcgg agctgctggc agtcagcgcc      900

ccggcgctgc agggttcccg gcctggggag accgaggaga acgtgcggcg ggtcttccag      960

cgcgcccggg aactggccag ccgcggaccc agcctcctct tcctggacga gatggacgcc     1020

ttgtgtcccc agcggggcag tcgagcaccc gagagccgcg tagtggccca ggtgttgacg     1080

ctgctggacg gcgccagtgg ggaccgcgag gtcgtggttg tgggagccac taaccggccg     1140

gacgctctag acccagcgct gcgtaggccc gggagatttg accgagaggt ggtcattggg     1200

actcccacac ttaaacaaag aaaggaaatt ctgcaagtga ttacctcgaa gatgcccatc     1260

tccagtcatg ttgatttggg ccttcttgca gaaatgacag ttggctatgt tggtgccgac     1320

ctgacagcac tctgtaggga ggctgccatg catgccctcc ttcatagtga gaagaaccag     1380

gacaatcctg tgattgatga aatagacttc cttgaagctt ttaaaaatat tcagccctca     1440

tcgtttcgaa gcgtcattgg attaatggat atcaagcctg ttgactggga ggagattggt     1500

ggccttgaag atgtaaaact gaagttaaaa cagagcattg agtggcctct gaaattccct     1560

tgggaatttg ttagaatggg cctgacacaa ccaaagggag ttctcctcta tgggccccct     1620

ggatgtgcta aaaccactct ggtgagggcc ctggccacaa gctgtcactg ctctttcgtt     1680

tcagtgagtg gagctgatct gttttcaccg tttgttggag attcagaaaa agtgttgtct     1740

cagatatttc gacaagcaag agcaagcact ccagcaattt tgtttttgga tgaaattgat     1800

tcaatcttgg gagctcgctc agccagcaag acaggatgtg atgttcaaga acgagttctt     1860

tctgttctcc tgaatgaatt agatggtgtt ggacttaaga caatagagag aagaggaagt     1920

aaatcaagtc aacaggagtt tcaagaagtt tttaaccgaa gtgtcatgat tattgcagca     1980

acaaatagac ctgatgtgtt agatactgct ttgttacgac ctggaagatt agataagatc     2040

atctatatcc cacctccaga tcacaagggc aggctttcta ttttaaaagt ctgtacaaaa     2100

accatgccaa tagggcctga tgtctcctta gaaaacctcg cagcagaaac ctgttttttt     2160

tctggagctg atcttagaaa cctctgcaca gaagctgctt tgctggctct gcaagaaaat     2220

ggactagacg caactacagt gaaacaagag cactttctaa aatcacttaa gactgtaaaa     2280

ccgtcgttaa gttgcaagga cttggcttta tatgaaaact tatttaagaa agaaggattt     2340

tctaacgtgg aaggtattta aaaatcacct taaactcttg ttcagttcac attaattgaa     2400

atgtgaactt gcctgtcgtt tgcaacttca cacttttaga atttgtgttt atatttcctg     2460

taagtgaata aataaaacaa aacaaaacaa aaaaaacttg tgcctgataa gctaaggctc     2520

atttattttt aaaaggcata ttaaataaaa tactgtaatt taggaagaaa                2570


<210> 737
<211> 3421
<212> DNA
<213> Homo sapiens

<400> 737
agttagttcc ctaacccgag tgaagccact tccgggcttc ccgggcgcct tccgcagtcc       60

tcttccgggt gatggcggcc gggtgccccg gatgtagccc tggcgcaagc atctcttctt      120

ttttccacct cgccttccgc ggattcccag cttgagaaac acctctttgc cccgtcatgc      180

caaagaggaa agtgaccttc caaggcgtgg gagatgagga ggatgaggat gaaatcattg      240

tccccaagaa gaagctggtg gaccctgtgg ctgggtcagg gggtcctggg agccgcttta      300

aaggcaaaca ctctttggat agcgatgagg aggaggatga tgatgatggg gggtccagca      360

aatatgacat cttggcctca gaggatgtag aaggtcagga ggcagccaca ctccccagcg      420

aggggggtgt tcggatcaca ccctttaacc tgcaggagga gatggaggaa ggccactttg      480

atgccgatgg caactacttc ctgaaccggg atgctcagat ccgagacagc tggctggaca      540

acattgactg ggtgaagatc cgggagcggc cacctggcca gcgccaggcc tcagactcgg      600

aggaggagga cagcttgggc cagacctcaa tgagtgccca agccctcttg gagggacttt      660

tggagctcct attgcctaga gagacagtgg ctggggcact gaggcgtctg ggggcccgag      720

gaggaggcaa agggagaaag gggcctgggc aacccagttc ccctcagcgc ctggaccggc      780

tctccgggtt ggccgaccag atggtggccc ggggcaacct tggtgtgtac caggaaacaa      840

gggaacggtt ggctatgcgt ctgaagggtt tggggtgtca gaccctagga ccccacaatc      900

ccacaccccc accctccctg gacatgttcg ctgaggagtt ggcggaggag gaactggaga      960

ccccaacccc tacccagaga ggagaagcag agtcgcgggg agatggtctg gtggatgtga     1020

tgtgggaata taagtgggag aacacggggg atgccgagct gtatgggccc ttcaccagcg     1080

cccagatgca gacctgggtg agtgaaggct acttcccgga cggtgtttat tgccggaagc     1140

tggacccccc tggtggtcag ttctacaact ccaaacgcat tgactttgac ctctacacct     1200

gagcctgctg ggggcccagt ttggtgggcc cttctttcct ggactttgtg gaggaggcac     1260

caagtgtctc aggcagcgag gaaattggag gccatttttc agtcaatttc cctttcccaa     1320

taaaagcctt tagttgtgta ctggggcctt ggctgtgctg atggccagaa gccaggggcc     1380

ttctccacag tccctttgga cttgtcttgg tccctgagta ctcccatgaa gatccttctt     1440

ggaggtgcct gtcaggtatc ctgtggcctc cctgcctgga ctctgcttgc cgtgtaaaca     1500

cccccaactg cgctgctctg tgctcctctc ccaggtttct tgttcgattc ctcttaggtc     1560

tttggctttc aggacctcag attctttatc cttgtagcca ccagaggaca gagccccaga     1620

agtggatgtt ttaggcccag aaggaccagg gcatcgagaa gacattggga ccctgttggg     1680

ggtgagcatg gaaccctctt actctcgctt caccctctca agctccttag atgctgggca     1740

gaagtgggat gagtggccca agaccgagat ccctaaggtt ctgagagcca gtgtcttccc     1800

taatctggct ttcctctatc cttgccgtcg ttcccacagc ccttcagtga agtgcaaact     1860

cagtggccaa gtgtgggcca agtgtgcatt gtactggcac agagaggggc agtgactcac     1920

tggagatcac aggaatcaaa gggctggccc agacccagtg ggctcctttc ccagaccttt     1980

cttggcacaa agcctttgct gcctggcctt ggaggccctg cggcctacat tctctggacc     2040

ccactatgtg cctggcacag ggctagtgcc ttgaggaaac tgaggtagct gggttggtcc     2100

ccttccagga attcagagtc tggtggcagg ggcatgggaa atagacagat gtaattctat     2160

agcctgggcc tggcaccctc cacctccacg ccccaccagc attgccttac gcctcccttg     2220

ccccacgtta gatggtttct tccggttttg cactctggct gccccttgga gtctcctggg     2280

gagctgtaat atctctttgg agattcagat tgagctggtc taggttgtgg cccaggcatt     2340

gggcattttg gaagccccca ggtgttttca gcttgcagcc aggccgagag agagcccctg     2400

agtcagatcc ccatggttta ggcacaccta gcgggagggg tggctcctgg accccaccgt     2460

ggttggagag ctgagcatgt gtgtggcttt agtggggtct gttagttatg ggggtctggg     2520

cactggagct gcaggacact tgggatccca ggtcagaaag ggccagatga gcaactagga     2580

aagacttggg ggccagggcg gagtggggtc acctgacact cttgtgaggc cccttctagt     2640

gcctgctcac accggaattt cattcactcc aagaagccat caggggtaag ataccttcct     2700

ttaaacgtca ctaagaaaga agaggcctgc cggtgacaca gtaagatgcc attgatctaa     2760

agatgcgtct tgatttcaga aaggtccgga agtggaaagc aggtttcagg gctgctgagg     2820

tacagggttc tcctgtaggc cccagggatg gtctcagggg tgctgagtgc gtgcgtggta     2880

aatggatgga gcccaggggc gcctcctgcc agtgtcctcc aggcactcaa acctagccct     2940

tctgaagccg acctcacgtg acctcacagc ccctcctgaa ggcgcctcac tgatgacggt     3000

gggtggaata acagccccca gagatgtcca ggtttggaac cccaggacgt gggaaagtgt     3060

taccttgcgt ggcaaaaggg acccggcgcc tgtgcttcag ttcaggattt cgtggtgggg     3120

agatgaccgt ggatggttga ggtgggccct gagtaatcat gggggccctt ataagggaag     3180

gggagtcacg agggtctgcg catgaagcaa ggaagcttct ggctgtgaag atggcaagaa     3240

ggcctggggc caggcgatga ggtggcccct ggaggagctg gaaaaggcat tggattctgc     3300

cccagagcct ccgtggagaa acaaagccgc actgacaaga cttcagcctg gtgaaaacca     3360

ttttggactc ctgacctcta gaactgtaag ataataaatt ggtgtggttt tcaacctctc     3420

a                                                                     3421


<210> 738
<211> 4562
<212> DNA
<213> Homo sapiens

<400> 738
gcttcctcca gagggcggga accttggacg tggcggggct gggtcagtca gggcgctggg       60

cccagcctct ctgcaggctg gccttccgcg ctgccgtgaa gcccccgaca ggtcccacgc      120

ctgcctaggt agaccggcgc cagcccgagt gacgcctggc gtgtggccgc gggcaggcgg      180

ctccgtgcgg cggggcgggc gggtgccaca cctgtgcggg caagggcggg gcgggaaggt      240

gcgcaggcgc gctcggggct ggtgggcggt ggctcctggg aagttgcgca gccgaactgg      300

ccggctgggc gcgcgctctt gcggtggcgt aatctctcag cctttctgtg tctcctttcc      360

tccgcctcag tttggggcgg gtcgggggaa tggctgagga gatggagtcg tcgctcgagg      420

caagcttttc gtccagcggg gcagtgtcag gggcctcagg gtttttgcct cctgcccgct      480

cccgcatctt caagataatc gtgatcggcg actccaatgt gggcaagaca tgcctgacct      540

accgcttctg cgctggccgc ttccccgacc gcaccgaggc cacgataggg gtggatttcc      600

gagaacgagc ggtggagatt gatggggagc gcatcaagat ccagctatgg gacacagcag      660

gacaagaacg attcagaaag agcatggttc agcactacta cagaaatgta catgctgttg      720

tcttcgtgta tgatatgacc aacatggcta gttttcatag cctaccatct tggatagaag      780

aatgcaaaca acatttgcta gccaatgata taccacggat tcttgttgga aataaatgtg      840

acttgagaag tgccatacag gtacccacag acttggcaca aaaatttgct gacacacaca      900

gtatgccttt gtttgaaacg tctgctaaaa accccaatga taatgaccat gtggaagcta      960

tatttatgac cttggctcat aagcttaaga gccacaaacc attaatgctt agtcagcccc     1020

ctgataatgg aattatcctg aagcctgaac caaagcctgc aatgacgtgc tggtgctaaa     1080

taacagtctt tattatatta tctaattttg actaaagaaa tacttttgaa gtatgacagt     1140

attaagtcat aagatttaat ctcaactata atgggtcatc ttgacacttt gctgtttgtc     1200

attgtcacgc ttttgtattt tgtatctact taagtttgtc actgtgacaa cacaggaaaa     1260

gttggttttc aggtgagatt gaaaatgaag caaagatagg atgaatctga acatctctcc     1320

atctagagcc caatgaagga agcttcaaat gagaacatga tggaatcagt aaccattcaa     1380

tcttttgtcc taggattgga aaaaaatgtt aaaggtttag gacacaccta atagtatgtc     1440

ctttgaatgg gaagtgttct taataggata aaaactggta tttgcctctc cccagagtac     1500

tttttttgtt ttttcataga gacggggtct tgctatgttg tccaggctgg ccttgagctc     1560

ctgggctcaa gcaatcctcc cacctcagcc tccccagtac tgggactgta ggtactcacc     1620

actgcatctg gcctttcttt gttttattaa catatttagt tttgttatta ttggtatgtt     1680

ttagagccaa gactttagtt ccagtgggat aagaaggcat agaatgtttt ctggttccca     1740

gtccataaag aatgactttt ccaagagttc tagatgtttg attttctaat taatacttat     1800

cagatctaca aaaatcatta ttattttaaa agagttattt gagtttcttt ctttcttttt     1860

tttttttttt ttttttgaga tggagtctcg ctctgtctcc aggctggagt gcagtggcgt     1920

catctcggct cactgcaacc tccgcctccc aggttcaagt gattctcctg cctcagcctc     1980

ccgagtagct gggattacag gcgtgcacta ccacacccag ctgatttttg tatttttagt     2040

atagatgggg tttcaccatg ttggccagga tggtctcgat ctcttgacct catgatccac     2100

ccgcctcagc ttcccaaagt gctgggatta caggtgtgag tcactgcacc cagccgagtt     2160

gctttcttac taaatcctat taaaatatgc aaaaataagt cagattttaa ggcaaataaa     2220

gtgacataag gtgctttata ttttattttg gtatatttaa acagtgaaaa actaactgaa     2280

agcacatgaa gagttgtaac ttgggggaaa ataggtaaac atagcttcta gctaacacag     2340

gagacctatt cttagccttt actaatttca agcagtgtat cccatatggt atctcttgct     2400

cttccttcaa ctccaataaa tttaatgact aaatgccaag ttaacaaatc aacttccatt     2460

tggattgtag gtgtgaaggc acaactctaa ttgctattag tctacatgta tttctgtaat     2520

agtattgtgt catatcaatt tttaagatgt ctaaatttta tggtcacaag ttatccctcc     2580

tcagtatgaa aaataaatta gatattgaaa aatgtctaaa cttcagtgat ggaaagaata     2640

tttcaagaag ttttttaacc taaatacttt tattttgaat ttaagtcttt gcacataaaa     2700

tatagcaagc ttacatatta aactatttac gtaaatggaa tgtaagccat gactttaact     2760

gaagtgttca cattcactaa ttttgataga ttgctgtcct taataatttt ggaggaaatt     2820

aagccaaatg attattgtac tacagtattt tcagaatatg ggaaatcaat taaaaatgta     2880

atctaatcta gtttaagatt tttgtttaat catcatggtg gtcctacctg gataatttaa     2940

ctataaagac aaagtaattc tattaaatga actaactgaa aataataatt ataggaagtg     3000

attattccat tttaagtatt agagctcaaa ttggctttat ttgcatttag ggagatcatg     3060

ttttcttaat catgctggaa tttaaaaatt gttttacttg tatcgaaatt aaccttgatt     3120

tataactatt tttgtaataa aacaatgaca gctgtagtaa ctatgatggg tgtaacaaca     3180

tttttttaaa gaagggaatc tgtttatcgc ttttcaaaat attttctaaa gtgggggaag     3240

aaagtttata gactttccaa gcacatttat ggttttttat tactattatt atggttttaa     3300

aaagagtaac tttatttctt tttgtaagga attaagtaat atcctttaca gttctgtgaa     3360

aggacttatt ttttaactgt aatatttatt agttttaaaa tatttgtatc tcatttgtaa     3420

caatttgttt taatttttta tatatatgtt tttattttta aaaaacatac cagttgaatg     3480

gggttaaagc tttcaatatc ttaaaatatt tataaaacat ttcactgttg caaaatcact     3540

tccaaaatga tagctatcta acaactaatt actaattttt aaagaacaaa tcacacattt     3600

aaaaaatctg tagaatttat tttaactatg acctttaatt gaaaataaat aattaaaata     3660

tcagacatgt tttggaaaag tcttaatttg agaacaccaa aggaaactac cccagaatct     3720

aatgtagttc gctattaata acaatgcatt attgaaagta tattgcaaat acatgtttcc     3780

tcatgaaatc taagtaattt tgttgtggaa tagtgtcact gttacatttc ccccatgaag     3840

ttcaataaac cagcttagcc acaaagaaat tgtgttttat tttctttgtt tggttactgg     3900

gtagagtata aaataaaaca atcttttttt cctcctggtt tccagataat attatatata     3960

tgatacactt ttgaaaacaa caaaaagccc ccaacccatt ggacaattat tttcttgtat     4020

acatttgagg tcaaagaaca cttcaggaaa aaaactcaac aaagtattaa aattagctga     4080

taacacagct tttgtatttg tgtgttttag taatccagct tgttttagaa tagttcagtg     4140

caaaaagcaa atggtgcaag aggagttgat gtgtatttag acgtaaaagc atttaacaga     4200

atgaataact atagaaagta tgagaaaaga gaacgaacta cgtctcaggt ataagattgc     4260

agttactgat ttagacacca taggattagg gatgtggggg cctctgatgt tgattctgct     4320

tcccctggtc agtttatttt acgtataagt tacccttgtg ttcaaacaca aaattgacat     4380

tattcatgaa ggactgcttt cttaatcaga tattaagaag ttcgtcatgt attttgggag     4440

cacgtttgct acagcctgtg tggcaagggc gaatgcactt ggtttgttgg aataacctga     4500

tttatcaaac atttatcaag tatgggtcat gtgttctcta tttgtgttag tggagctaca     4560

ta                                                                    4562


<210> 739
<211> 2601
<212> DNA
<213> Homo sapiens

<400> 739
cctgcggcgg gctttaggga gtggtccctg gctgtggata gatctgctga tgagtccagg       60

ccccggtcca ttctcctcgc gctgcaagga tgctcctggg atttcggaga ggccgcagga      120

gtcatttcaa acacatcatc catggccttt tacctgcagc cagcgttgct ccgaaggcag      180

ctgtgccacg cacacctcct ccccgcagcc ccaacccatc tccagagaga ccaagatctg      240

ctctggcagc agccattctg gcgacaacat tgactgggcg gacggttgct attcctcagc      300

ctcgccagag gtcccggtct gagagtgatg tgagcagtgt tgaacaggac agcttcatcg      360

agccctatgc caccacctca cagctgaggc ctcggccaaa ttggcagagt gagatgggaa      420

gaagatcttc tttgccatcc tttgaaacac tggactatgg ggacgaagag gacattgaaa      480

ctcagctgtc atccagcggc aaggaattgg gggatgtcag tgcccgggag gacagaggag      540

gccacagtga tgacctgtac gctgtgccac acagaaatca ggtgccattg ttacatgagg      600

tgaacagtga agacgatgaa aatatttctc atcaagatgg gtttccaggc tcccctcctg      660

caccacagcg gacacaacaa aaagatggta aacaccctgt tctgaattta aaggatgaaa      720

aacctccatt atgtgagaaa cctccaccct ccccagatat aactggtaga gcacgtcaaa      780

gatatacaga aataaccaga gaaaagtttg aggcattaaa agaagaaaat atggacctaa      840

acaatatgaa tcaaagcctt acccttgaac taaacacaat gaaacaagca atgaaagaac      900

tacagttaaa acttaaggga atggaaaaag agaagagaaa gctcaaagag gctgagaagg      960

cgtcgtcaca ggaagttgct gcacctgaat tactttatct gcgaaaacaa gctcaagaac     1020

tggtggatga aaatgatgga ttgaaaatga ctgtccatcg tttgaatgta gaactcagtc     1080

gatatcagac aaaattcagg catttgtcca aggaagagag cttaaatatt gaaggcctcc     1140

catccaaggg ccctatacca ccctggttgt tggatataaa gtacctgtca ccattgttgc     1200

tggcttatga agatatgatg aaagagaagg acgagctcaa tgccaccctc aaggaggaaa     1260

tgagaatgtt taggatgcga gtccaagaag tggtgaaaga aaatgaagaa ttgcaccaag     1320

agttaaataa gagtagtgct gttaccagtg aggaatggcg tcagcttcag actcaagcaa     1380

aactggtttt agaggaaaac aagttgttgc tggagcagtt ggagattcag caaaggaaag     1440

ccaaggacag ccaccaggag cgcctccaag aagtttctaa gctgactaaa caactaatgc     1500

tcctggaggc aaaaacccac ggccaggaaa aggagctggc ggagaacagg gaacagctgg     1560

agattttacg tgccaaatgc caagaactca aaacacactc ggatggcaaa atcgcagtgg     1620

aagttcataa atcaattgtg aatgaattaa aaagccaatt acagaaggaa gaagagaaag     1680

aaagggctga gatggaggag ttgatggaga agctgacagt cctgcaagcg cagaagaaga     1740

gcctgctgtt agagaagaac agtttgacag agcaaaacaa agcactggaa gccgaacttg     1800

aacgagcaca gaaaatcaat aggaaatctc aaaagaaaat tgaggtcctc aaaaagcagg     1860

tggaaaaagc catggggaac gaaatgtctg ctcatcagta cctggcaaac cttgttggcc     1920

tggcagaaaa cataacccag gaacgtgaca gtcttatgtg tttggcaaaa tgtttagaaa     1980

gtgagaagga tggagtgctt aataaagtca taaaaagcaa cattcgcctg ggaaagttag     2040

aggaaaaagt caagggctac aagaagcagg cagcactgaa gctgggggac atcagtcacc     2100

gtctgctgga gcagcaggag gacttcgccg gcaagacagc ccagtaccgg caggagatgc     2160

ggcacctgca ccaggtgctg aaggacaagc aggaggtgct ggaccaggcg ctgcagcaga     2220

acagagaaat ggaaggtgaa cttgaagtta tttgggaatc taccttcagg gaaaaccgaa     2280

gaatccgaga acttctccag gacacactca cgaggacagg cgtgcaggac aaccccagag     2340

ctctggttgc ccccagcctc aatggcgtct ctcaggcaga cctgctggac ggctgcgatg     2400

tctgctccta tgacctgaag tctcatgccc ccacctgcta gaatctgcgg gagcccgtgg     2460

tgtagcctcc tctggcctga aaggtctgcc tcacacaggc cttccctgca gggcagccca     2520

tggtggcagc cggaggtgcg taagcccact gaacgctgca gggcagggaa gaaataaatg     2580

gtctcatagt ttaatccatt g                                               2601


<210> 740
<211> 1232
<212> DNA
<213> Homo sapiens

<400> 740
aggacacggc tccagtggcg gcgcggccca gggcgcaggc gcgggtgtcg gtcccaccgc       60

gcgtcgtcct cgccccggcc ccggccaatc ccttcgaatt tggccgaggc cgggaaatac      120

tagctaatca cggcgcgcgc tgttgacgcc ggccaatggg agctccggaa ggctgcgtgg      180

agacgccagc ggcgggcggt ggacagtcat ggcggcccgg cgcggggctc tcatagtgct      240

ggagggcgtg gaccgcgccg ggaagagcac gcagagccgc aagctggtgg aagcgctgtg      300

cgccgcgggc caccgcgccg aactgctccg gttcccggaa agatcaactg aaatcggcaa      360

acttctgagt tcctacttgc aaaagaaaag tgacgtggag gatcactcgg tgcacctgct      420

tttttctgca aatcgctggg aacaagtgcc gttaattaag gaaaagttga gccagggcgt      480

gaccctcgtc gtggacagat acgcattttc tggtgtggcc ttcaccggtg ccaaggagaa      540

tttttcccta gattggtgta aacagccaga cgtgggcctt cccaaacccg acctggtcct      600

gttcctccag ttacagctgg cggatgctgc caagcgggga gcgtttggcc atgagcgcta      660

tgagaacggg gctttccagg agcgggcgct ccggtgtttc caccagctca tgaaagacac      720

gactttgaac tggaagatgg tggatgcttc caaaagcatc gaagctgtcc atgaggacat      780

ccgcgtgctc tctgaggacg ccatccgcac tgccacagag aagccgctgg gggagctatg      840

gaagtgaccc aaggctgccc actggagacg cctctccctg cagtcccccg agaggtggga      900

gactcgcgga aggccccgtc cccagcagag tccagacccc acaacttcag gagctctttc      960

ccggcagcag agatctgcag gctgcctctt ctgccccgga gctggggtgc actggggacc     1020

cccgtggtgg ggaccttggc agtgtggaca tgagcagagc gatggagcag tctcctgccc     1080

tctcccctgt cctgatggca ctctgttgta ttttcttact gaagttcagt gataactctg     1140

agcagtttca ttgtgatcac tgtaaatggt aatcagttgg aattctccta aatgtcttcc     1200

agacactagt aaaaaacgac ctgaaaattg tt                                   1232


<210> 741
<211> 804
<212> DNA
<213> Homo sapiens

<400> 741
gctggggctt gcgtgggagg aaggtgactg tgaggaaggt gtgtgtccac cgagcacttg       60

gattcagctt cttcatttcc aacatggaag aaacttacac cgactccctg gaccctgaga      120

agctattgca atgcccctat gacaaaaacc atcaaatcag ggcttgcagg tttccttatc      180

atcttatcaa gtgcagaaag aatcatcctg atgttgcaag caaattggct acttgtccct      240

tcaatgctcg ccaccaggtt cctcgagctg aaattagtca tcatatctca agctgtgatg      300

acagaagttg tattgagcaa gatgttgtca accaaaccag gagccttaga caagagactc      360

tggctgagag cacttggcag tgccctcctt gcgatgaaga ctgggataaa gatttgtggg      420

agcagaccag caccccattt gtctggggca caactcacta ctctgacaac aacagccctg      480

cgagcaacat agttacagaa cataagaata acctggcttc aggcatgcga gttcccaaat      540

ctctgccgta tgttctgcca tggaaaaaca atggaaatgc acagtaactg aatacctatc      600

tcatcaaatg ccagacccta gaagactgtt gcttcttctt ctaccagtgg gttctcattt      660

tcctcctaat ctaattatag aatggtaaac tccctgtgac tttccaaact gacaagcaca      720

cttttttcct ccccccttga atcctcattt aatgcaagaa ccctcatact cagaagcttc      780

caaataaacc tttgatacag attg                                             804


<210> 742
<211> 3017
<212> DNA
<213> Homo sapiens

<400> 742
ccgcaggcag tagagtgaag cgcgcagctg ccaggacttg cgcggtgacg tgcgccgctg       60

ccaggacctt gcaggtggag agcatagttg ccaaaatcaa ggcggaggag cgcaccgccg      120

ctaggatcca ggcggagaag cccaccgcgg ccaggaccta aggatgcagt acactgctgc      180

caggatcttg tctgtggagc gcagcgcggc caggacctcc ggctgcagca caccgctgcc      240

aggatcttat cggcagagcg ctccgcggtc cggaccccgc cccgtgcgcg tccccgaccc      300

cgccccgtgc gcgtccccgg cgttggcgtc ttcgtcctgt tgctggtctc cgtccggtcg      360

ccggccgtct aggtctccgg ccctccccag ccgctcctgc gcccttgccg gccccgccgc      420

ccgcagccct ggcgctccct gcgggccccg ccgaggccgc ctgcgccctg tgccagcgcg      480

cgccccggga accggtgcgc gccgactgcg gccaccgctt ctgtcgggcg tgcgtggtgc      540

gcttctgggc cgaggaggac gggcccttcc cgtgccccga gtgcgccgac gactgctggc      600

agcgcgccgt ggagcccggc aggcccccgc tcagccgccg ccttctggcg ctcgaggagg      660

cggccgcggc gcccgcgcgc gacggcccgg ccagcgaggc cgcgctgcag ctgctgtgcc      720

gcgccgacgc cggcccgctc tgcgccgcct gccgtatggc tgcgggcccc gagccgcccg      780

agtgggaacc gcgctggagg aaggcgctgc gcggcaagga gaacaagggg tctgtggaaa      840

tcatgagaaa ggacttgaat gacgcccggg acctgcatgg ccaggcagag tcagcagctg      900

cagtgtggaa gggacacgtg atggaccgta ggaagaaggc actgaccgac tacaagaagc      960

tgcgggcctt ctttgtggag gaggaggagc atttcctgca ggaggctgag aaggaggagg     1020

ggctccctga ggacgagctg gctgacccca ctgagcggtt caggtcactg ctgcaggcgg     1080

tctcggagct ggagaagaag catcgcaacc tgggcctcag catgctgctg cagtgatggc     1140

gccaacccgt ggcagtccca gagctggagg caggaggatg gatcctcatc tccatgggaa     1200

gtgtcagcgt gtggctgcca gggaagcgtg gcaggcgcct ggccttgggt ccatctacat     1260

agttgcgtgt ttcaacaatg tccatttatc cttcaccccg aggcgtgttt tgggggctgc     1320

aaacacctcc cggtagaggc tggacctgag gacccttccc acctgtgccc gtcccttcct     1380

gaagtcctag ccacagccca tcctccatga gtcccggcag ctctgggtca tgcccttccc     1440

tggtcaccca tctgcccctc acctcgtcat ccagggaccc agaccctgca ccttccatgt     1500

gggcccacag atccttggca ggtacctgag gtgcaccatt gagtgtcgga tttggggtta     1560

gcatccagaa agaagaatgc gcatgacgct ctgtgaaggc tggaactcag gtcttcaggg     1620

agagaaagga agactggatt gcaccttgat gcctcctgag gaggcggccc ccctcttgag     1680

gtgggcgtgg gcccggccca gccttatcca agtcgctctg tccacctccc ccttcctggc     1740

ccccacccca ctcctgtgcc tcccaggagc cctccctgtg ctccacctgc ctccgcagaa     1800

ggaagcctct ttctctgttt ccctgggtga gggggctggc aggtggctaa ccccatttag     1860

catctccagg ccctgccatc gtgtctcatc ttgctgttat ctctagctct ttccctcctc     1920

ccatttcctt tagtagttga attttgcaaa gcttgtagca gtagctcagt tgcctgcagc     1980

atccttgtgt gtagataaat tagtcgacag aaactcagca ctggggacag gattgcaaag     2040

tcggggacat agatgcagac agttgttgag atttggggat agccgggctt gtgagcggtg     2100

cccatttcca gatgaagcct ttcagccctt ctgagtcccc ggcccttggt gcgatgtctg     2160

tgagtttgac ctgcccagcg tgtgggctgg ctcaatgctg aataaagtgg gtttgtgtca     2220

gctcgtttgc ttcgtctccg tgtgtccacc tggcctcttc cccctgccct ggccaccctc     2280

cagtgtcaaa ggaaacttcc tcgtgacacg tgctaaagca tggtgaggag gactttgatt     2340

gggaccattg agatgggtgt gggacccttt ccttggggcc tggggggaga tggggctcca     2400

ccccgacgta gcagggcagg ggttggagga gcgaggagca gtatagggtc catgggtggg     2460

aatgactgtg aggagacatc agggctgagg gggctctggc taaacccacc tcacagagtc     2520

cttgctgcag gcaggcaggg cgatcagaca ttggctgcaa acggtcagag aggaacccag     2580

tcaggtacca ttgagggtgg tcagatatta tggttaacca aattagggtt cttgctaaaa     2640

ctggatttca taagaaaggg caaagagggc cctaggagaa gattccagag cctggccaga     2700

gtttggccaa gtagagaatc tttgtcagca cgccaacaac atcccgaccc tgagacctcc     2760

agtttgtctt tctcactgtc tccgcctgct gcagtctgct gtcatccctg agcatccctg     2820

cccctgccct gcacacctgt gatgcttgcc cggacaggtc ctgatggcag agtctcccac     2880

aacatcagtg tctccacatc accaggtccg acagtggctt caccatcctc acctaaccta     2940

gctgaccagc aacatcccac cctgtcaatc acaacctctt tctatttaag aaaattatat     3000

atttatgggg cacagtg                                                    3017


<210> 743
<211> 2233
<212> DNA
<213> Homo sapiens

<400> 743
gccgggccgg agcggggtgg gtaggggacg cgaggcggag cggggcccca cacaggccgc       60

ggcggctggc tcgggcccct acggtcccgg cggcggctgg aggaggaagc caggcggctg      120

gcggaggagg agagacggag gaggccgaga ccggagcgcc gctcgccgca gacttacttc      180

cccggctcag cagggaaagg ttcctagaag gtgagcgcgg acggtatgca aagttgtgaa      240

tccagtggtg acagtgcgga tgaccctctc agtcgcggcc tacggagaag gggacagcct      300

cgtgtggtgg tgatcggcgc cggcttggct ggcctggctg cagccaaagc acttcttgag      360

cagggtttca cggatgtcac tgtgcttgag gcttccagcc acatcggagg ccgtgtgcag      420

agtgtgaaac ttggacacgc cacctttgag ctgggagcca cctggatcca tggctcccat      480

gggaacccta tctatcatct agcagaagcc aacggcctcc tggaagagac aaccgatggg      540

gaacgcagcg tgggccgcat cagcctctat tccaagaatg gcgtggcctg ctaccttacc      600

aaccacggcc gcaggatccc caaggacgtg gttgaggaat tcagcgattt atacaacgag      660

gtctataact tgacccagga gttcttccgg cacgataaac cagtcaatgc tgaaagtcaa      720

aatagcgtgg gggtgttcac ccgagaggag gtgcgtaacc gcatcaggaa tgaccctgac      780

gacccagagg ctaccaagcg cctgaagctc gccatgatcc agcagtacct gaaggtggag      840

agctgtgaga gcagctcaca cagcatggac gaggtgtccc tgagcgcctt cggggagtgg      900

accgagatcc ccggcgctca ccacatcatc ccctcgggct tcatgcgggt tgtggagctg      960

ctggcggagg gcatccctgc ccacgtcatc cagctaggga aacctgtccg ctgcattcac     1020

tgggaccagg cctcagcccg ccccagaggc cctgagattg agccccgggg tgagggcgac     1080

cacaatcacg acactgggga gggtggccag ggtggagagg agccccgggg gggcaggtgg     1140

gatgaggatg agcagtggtc ggtggtggtg gagtgcgagg actgtgagct gatcccggcg     1200

gaccatgtga ttgtgaccgt gtcgctaggt gtgctaaaga ggcagtacac cagtttcttc     1260

cggccaggcc tgcccacaga gaaggtggct gccatccacc gcctgggcat tggcaccacc     1320

gacaagatct ttctggaatt cgaggagccc ttctggggcc ctgagtgcaa cagcctacag     1380

tttgtgtggg aggacgaagc agagagccac accctcacct acccacctga gctctggtac     1440

cgcaagatct gcggctttga tgtcctctac ccgcctgagc gctacggcca tgtgctgagc     1500

ggctggatct gcggggagga ggccctcgtc atggagaagt gtgatgacga ggcagtggcc     1560

gagatctgca cggagatgct gcgtcagttc acagggaacc ccaacattcc aaaacctcgg     1620

cgaatcttgc gctcggcctg gggcagcaac ccttacttcc gcggctccta ttcatacacg     1680

caggtgggct ccagcggggc ggatgtggag aagctggcca agcccctgcc gtacacagag     1740

agctcaaaga cagcgcccat gcaggtgctg ttttccggtg aggccaccca ccgcaagtac     1800

tattccacca cccacggtgc tctgctgtcc ggccagcgtg aggctgcccg cctcattgag     1860

atgtaccgag acctcttcca gcaggggacc tgagggctgt cctcgctgct gagaagagcc     1920

actaactcgt gacctccagc ctgccccttg ctgccgtgtg ctcctgcctt cctgatcctc     1980

tgtagaaagg atttttatct tctgtagagc tagccgccct gactgccttc agacctggcc     2040

ctgtagcttt tctttttctc caggctgggc cgtgagcagg tgggccgttg agttacctct     2100

gtgctggatc ccgtgccccc acttgcctac cctctgtcct gccttgttat tgtaagtgcc     2160

ttcaatactt tgcattttgg gataataaaa aaggctccct cccctgcccc tcagcttctc     2220

tctggttttc tca                                                        2233


<210> 744
<211> 4453
<212> DNA
<213> Homo sapiens

<400> 744
gtaaggggtg ggctataggg ccagatcgcc gcgcgagggt ggtgggcatc gaggtcccag       60

cagcggacga gggaggtgcc gccgtcgccc aggatgggct gggaatgaag cgatgtagcc      120

ttttaagaga tttgctctga cccatctgaa gtccatatgg ctctgtatga tgaagacctc      180

ctgaaaaatc ctttctatct ggctctgcaa aagtgccgcc ctgacttgtg cagcaaagtg      240

gcccaaatcc atggcattgt cttagtaccc tgcaaaggaa gcctgtcgag cagcatccag      300

tctacttgtc agtttgagtc ctacattttg atacctgtgg aagagcattt tcagacctta      360

aatggaaagg atgtctttat tcaagggaac aggattaaat taggagctgg ttttgcctgt      420

cttctctcag tgcccattct ctttgaagaa actttctaca atgaaaaaga agagagtttc      480

agcatcctgt gtatagccca tcctttggaa aagagagaga gttcagaaga gcctttggca      540

ccctcagatc ccttttccct gaaaaccatt gaagatgtga gagagttctt gggaagacac      600

tccgagcgat ttgacaggaa catcgcctct ttccatcgaa cattccgaga atgcgagaga      660

aagagcctcc gtcaccacat agactcagcg aatgctctct acaccaaatg cctccagcag      720

cttctgaggg actctcacct gaaaatgctc gccaagcagg aggcccagat gaacctgatg      780

aagcaggcag tggagatata cgtccatcat gaaatttaca acctgatctt taaatacgtg      840

gggaccatgg aggcaagtga ggatgcggcc tttaacaaaa tcacaagaag ccttcaagat      900

cttcagcaga aagatattgg tgtgaaaccg gagttcagct ttaacatacc tcgtgccaaa      960

agagagctgg ctcagctgaa caaatgcacc tccccacagc agaagcttgt ctgcttgcga     1020

aaagtggtgc agctcattac acagtctcca agccagagag tgaacctgga gaccatgtgt     1080

gctgatgatc tgctatcagt cctgttatac ttgcttgtga aaacggagat ccctaattgg     1140

atggcaaatt tgagttacat caaaaacttc aggtttagca gcttggcaaa ggatgaactg     1200

ggatactgcc tgacctcatt cgaagctgcc attgaatata ttcggcaagg aagcctctct     1260

gctaaacccc ctgagtctga gggatttgga gacaggctgt tccttaagca gagaatgagc     1320

ttactctctc agatgacttc gtctcccacc gactgcctgt ttaagcacat tgcatcaggt     1380

aaccagaaag aagtggagag acttctgagc caagaggacc atgataaaga taccgtccaa     1440

aagatgtgtc accctctctg cttctgcgat gactgtgaga aactcgtctc tgggaggttg     1500

aatgatccct cagttgtcac tccattctcc agagacgaca gggggcacac ccctctccat     1560

gtggctgctg tctgtgggca ggcatccctc atcgacctcc tggtttccaa gggcgccatg     1620

gtaaatgcca cagactacca tggagccact ccgctccacc tggcctgtca gaagggctac     1680

cagagcgtga cgctgctgct gctgcactac aaggccagcg cggaagtgca ggacaacaat     1740

gggaatacgc cactccacct ggcctgcacc tacggccacg aggactgtgt gaaggctctg     1800

gtttactacg acgtggagtc gtgcagactt gacattggca atgagaaagg agacacccct     1860

ctacacattg ctgcccgctg gggctaccaa ggcgtcatag agacattgct gcagaacgga     1920

gcgtccaccg agatccagaa cagactgaag gagacgcccc tcaagtgtgc attaaactca     1980

aagattctgt ctgtaatgga agcctatcac ctgtccttcg agaggaggca gaagtcgtcc     2040

gaggcccctg tgcagtcccc gcagcgctcc gtggactcca tcagccaaga gtcctccact     2100

tccagcttct cctccatgtc agccagctca aggcaggagg agaccaagaa ggactacaga     2160

gaggtagaaa aacttttgag agcagttgct gatggagatc tagaaatggt gcgttacctg     2220

ttggaatgga cagaggagga cctggaggat gcggaggaca ctgtcagtgc agcggacccc     2280

gaattctgtc acccgttgtg ccagtgcccc aagtgtgccc cagctcagaa gaggctggcg     2340

aaggttcctg ccagtgggct tggtgtgaac gtgaccagcc aggacggctc ctccccgctg     2400

catgtcgccg ccctgcacgg ccgggcggac ctcatccccc tcctgctgaa gcacggggcc     2460

aacgcaggtg ccaggaacgc agaccaagcc gtcccgctcc acctggcctg ccagcagggc     2520

cactttcagg tggtgaagtg tctgttagat tcgaatgcaa aacccaataa gaaggacctc     2580

agtggaaaca cgcccctcat ttacgcctgc tccggtggcc atcacgagct tgtggcactg     2640

ctgctacagc acggggcctc cattaacgct tctaacaata agggcaacac agcgctgcac     2700

gaggctgtga ttgaaaagca cgtcttcgtg gtagagctgc ttctgctcca cggagcgtca     2760

gttcaggtgc tgaacaagcg gcagcgcacg gctgtagact gtgctgaaca gaattcaaaa     2820

ataatggaat tgcttcaggt ggtaccaagc tgtgttgctt cattagatga tgtggctgaa     2880

actgaccgca aggagtatgt cactgttaag atcaggaaaa aatggaactc aaaactgtat     2940

gatctaccag atgagccttt tacaagacag ttttactttg tccactcagc tggtcagttt     3000

aagggaaaga cttcaaggga gattatggca agagatagaa gtgtccctaa tttaaccgaa     3060

ggttctttgc atgagccagg gaggcaaagt gtcacactga gacagaataa cctgccagct     3120

cagagtggat ctcatgctgc tgagaaaggc aacagcgact ggccagagag gcctggactg     3180

acacagactg gccctggaca cagacggatg ctgcggagac acacggtaga ggatgcggtc     3240

gtgtcccagg gcccggaggc tgctggcccc ctctccactc cccaagaggt tagtgcttcc     3300

cggtcctaac aggaatgagg agttgttgaa cccactgcta ggaagcaagg atgcaacaag     3360

atgatgctga gcgtgaacac atctgagaac taaatgtgct tccatgagac tggcttgaga     3420

agtcttcagc accaagttcc tgaaagcttt tctgtggcag gaaagaatgc aacaaaaaag     3480

ttaaccacca ccatctctct cctcttcaaa gctaatgaat acaattgaaa cagacaaaaa     3540

ttccagtagc atccagatcc ttaagccaga ggtgcatgct tctttttaag tatgagggtt     3600

tgttggtcac agtgggagag gtttcaccac cgcattctga cctcctcctc ccaaaaggtg     3660

ctaaacctct ctgacctgtg tacattcaca aaccacagct agaattcctc cacctaggat     3720

taagctggag agaagtaagt aatttaggtt tcatggtact gtagaggcca ggctgaaatg     3780

tcatatctga aggaagaaag cagcagctgg acaatgtttc tttgcaaagc aacactcgaa     3840

ccaaaagatg cctcaatccc attttgatat tcattttagt gaaaggatgc atcagacctg     3900

ttccacatca tgcacatggg aaagggtggt tatcattttc cttctaacaa gtaggtacag     3960

atattcggtt actacacgtg cacctgtagc agtatttcta gaaacatccc tttttgttga     4020

gaacctccct tgaatgtctg tcacactcac acctgacggg atggttactg gattagagag     4080

tagatttggc acatcttttc ttagtctttt gattcaaatt caaaacttaa cagcacaaac     4140

caggtcagag ttactttcgg ttagaattta ttgccattta ttccttttta taaatttcta     4200

tagattatac tgttattttt atgttattgg cctagagcta cacgtatatg ggtttgtcct     4260

gagtccgttt tcaaatgacc ttgtgatagg gaaatggttt tgtccatgtt cttggaaata     4320

cttgtgtatg tacagaagga agggagggat tatttttcta caaagtaatt tatgatttct     4380

aattttctaa tgtgccttgg atatgtgcca aatgatggaa aagaaacagt aaactttatg     4440

attcttgact gtg                                                        4453


<210> 745
<211> 1873
<212> DNA
<213> Homo sapiens

<400> 745
gaatgcgtag tcccagcctc agcacagggg agccaccttg aagctctcaa atatcactgt       60

tgtgaataca gagagggaaa accaactgta acgtgccacc caaatgtaag ttttactcat      120

attttgatgt taggatggat agcttggaaa aagttggagg gtacggcctt tactatgagg      180

catctatgaa ggatcaggaa tggatgtaga caaggaacta ggaatggaaa gtgttaaagc      240

tggagcctct ggaaaaccag aaatgaggct gggcactcag gaagaaacaa gtgaaggtga      300

tgctaatgaa agctcattac tagtcctgtc cagcaacgtg cctctcctgg ccctagagtt      360

cttggaaata gcccaggcca aagagaaggc ctttctcccc atggtcagcc acacgttcca      420

catgcgcaca gaggagtctg atgcctcaca ggagggcgat gacctaccca agtcctcagc      480

aaacaccagc catcccaagc aggatgacag ccccaagtcc tcagaagaaa ccatccagcc      540

caaggagggt gacatcccca aggccccaga agaaaccatc caatccaaga aggaggacct      600

ccccaagtcc tcagaaaaag ccatccagcc caaagagagt aacatcccca agtcctcagc      660

aaaacccatc cagcccaagc tgggcaatat tcccaaggcc tcagtgaagc ccagccagcc      720

caaggagggt gacatcccca aggccccaga agaaaccatc caatccaaga aggaggacct      780

ccccaagtcc tcagaagaag ccatccagcc caaagagggt gacatcccca agtcctcagc      840

aaaacccatc cagcccaagc tgggcaatat tgccaagacc tcagtgaagc ccagccagcc      900

caaggagagt gatatcccca agtccccaga agaaaccatc cagcccaagg agggtgacat      960

ccccaagtcc tcagcaaagc ccatccagcc caagctgggc aatattccca aggcctcagt     1020

gaagcccagc cagcccaagg agggtgacat ctccaagtcc ccagaagaag ccatccagcc     1080

caaggagggt gacctcccca agtccctaga ggaagccatc cagcccaagg agggtgacat     1140

ccccaagtcc ccagaagaag ccatccagcc caaggagggt gacatcccca agtccctaga     1200

ggaagccatc cagcctaagg agggtgacat ccccaagtcc ccagaagaaa ccatccagcc     1260

caagaagggt gacatcccca agtccccaga agaagccatc cagcccaagg agggtgacat     1320

tcccaagtct ccaaaacaag ccatccagcc caaggagggt gacattccca agtccctaga     1380

ggaagccatc ccacccaagg agattgacat ccccaagtcc ccagaagaaa ccatccagcc     1440

caaggaggat gacagcccca agtccctaga agaagccacc ccatccaagg agggtgacat     1500

cctaaagcct gaagaagaaa caatggagtt cccggagggg gacaaggtga aagtgatcct     1560

gagcaaggag gactttgagg catcactgaa ggaggccggg gagaggctgg tggctgtgga     1620

cttctcggcc acgtggtgtg ggccctgcag gaccatcaga ccattcttcc atgccctgtc     1680

tgtgaagcat gaggatgtgg tgttcctgga ggtggacgct gacaactgtg aggaggtggt     1740

gagagagtgc gccatcatgt gtgtcccaac ctttcagttt tataaaaaag aagaaaaggt     1800

ggatgaactt tgcggcgccc ttaaggaaaa acttgaagca gtcattgcag aattaaagta     1860

aacatgtatt ctg                                                        1873


<210> 746
<211> 3613
<212> DNA
<213> Homo sapiens

<400> 746
cctggctggg acggaagttg caccacaagt acaattagtt tcagttttgt ttcttttcca       60

ggcacccagc aacggcggcc tccaggcctc aggccccctc accatcctag aggtcaagat      120

cagctctggc tagttctcac aggtctgacc caacaagtag cactgacatt tttacgtttg      180

ctggatgtac acacggaagt ggaggaggag gaggagaagg aggagggcag ctccttagct      240

caagagcaag tggcccaagg cctcagaaga ctagaaggaa gttcctggcc attcagcatg      300

gtttcccacg ggtcctcgcc ctccctcctg gaggccctga gcagcgactt cctggcctgt      360

aaaatctgcc tggagcagct gcgggcaccc aagacactgc cctgcctgca tacctactgc      420

caagactgcc tggcacagct ggcggatggc ggccgcgtcc gctgccccga gtgccgcgag      480

acagtgcctg tgccgcccga gggtgtggcc tccttcaaga ccaacttctt cgtcaatggg      540

ctgctggacc tggtgaaggc ccgggcctgt ggagacctgc gtgccgggaa gccagcctgt      600

gccctgtgtc ccctggtggg tggcaccagc accggggggc cggccacggc ccggtgcctg      660

gactgtgccg atgacttgtg ccaggcctgt gccgacgggc accgctgcac ccgccagacc      720

cacacccacc gcgtggtgga cctggtgggc tacagggccg ggtggtatga tgaggaggcc      780

cgggagcgcc aagcggccca gtgtccccag caccccgggg aggcactgcg cttcctgtgc      840

cagccctgct cacagttgct gtgcagagag tgccgcctag acccccacct ggaccacccc      900

tgcctgcctc tggctgaagc tgtgcgtgcc cggaggccgg gcctggaggg actgctggcc      960

ggtgtggaca ataacctggt ggagctggag gcagcgcgga gggtggagaa ggaggcgcta     1020

gcccggctgc gggagcaggc ggcccgggtg gggactcagg tggaggaggc ggctgagggc     1080

gtcctccggg ccctgctggc ccagaagcag gaggtgctgg ggcagctacg agcccacgtg     1140

gaggctgccg aagaagctgc tcgggagagg ctggcggagc ttgagggccg ggagcaggtg     1200

gccagggccg cagccgcctt cgcccgccgg gtactcagcc tggggcgaga ggccgagatc     1260

ctctccctgg aaggggcgat cgcacagcgg ctcaggcagc tgcagggctg cccctgggca     1320

ccaggcccgg ccccctgcct gctcccacag ctggagctcc atcctgggct cctggacaag     1380

aactgccacc ttcttcggct gtcctttgag gagcagcagc cccagaagga tggtgggaaa     1440

gacggagctg gtacccaggg aggtgaggag agccagagcc ggagggagga tgagccgaag     1500

actgagagac agggtggagt ccagccccag gctggagatg gagcccagac cccaaaagag     1560

gaaaaagccc agacaacccg agaagaggga gcccagacct tggaggagga cagggcccag     1620

acaccccacg aggatggagg accccagccc cacaggggtg gcagacccaa caagaagaaa     1680

aagttcaaag gcaggctcaa gtcaatttcc cgggagccca gcccagccct ggggccgaat     1740

ctggacggct ctggcctcct ccccagaccc atcttttact gcagtttccc cacgcggatg     1800

cctggagaca agcggtcccc ccggatcacc gggctctgtc ccttcggtcc ccgggagatc     1860

ctggtggcgg atgagcagaa ccgggcactg aaacgcttct ccctcaacgg cgactacaag     1920

ggcaccgtgc cggtccctga gggctgctcc ccttgcagcg tggccgccct gcagagcgcg     1980

gtggccttct ccgctagcgc acggctctat ctcatcaacc ccaacggcga agtgcagtgg     2040

cgcagggccc tgagcctctc ccaggccagc cacgcggtgg cggcactgcc tagcggggac     2100

cgcgtggctg tcagcgtggc gggccacgtg gaggtgtaca atatggaagg cagcctggcc     2160

acccggttca ttcctggagg caaggccagc cggggcctgc gggcgctggt gtttctgacc     2220

accagccccc aggggcattt cgtggggtcg gactggcagc agaatagtgt ggtaatctgt     2280

gatgggctgg gccaggtggt tggggagtac aaggggccag gcctgcatgg ctgccagccg     2340

ggctccgtgt ctgtggataa gaagggctac atctttctga cccttcgaga agtcaacaag     2400

gtggtgatcc tggacccgaa ggggtccctc cttggagact tcctgacagc ctaccacggc     2460

ctggaaaagc cccgggttac caccatggtg gatggcaggt acctggtcgt gtccctcagt     2520

aacgggacca tccacatctt tcgggtccgt tctccggaca gttaaagggg ctaggactag     2580

ggtgagaggg agtggggagg gagagggcag gaaggaggca gagctgtccg tgggaggtgg     2640

aggccgagga cattttcctg aagggcaggg gttggcaact tttcaacatg gagtgccaaa     2700

ctgctaaccc gtcttctagt gtgtgagaat agggaccaag gtggtggcgt gaccttaact     2760

ctcagaagca gaggaggcag gtgggtggag ggggatgctg ggagttcacc tgcctcttgc     2820

tttttgtggg tggctgctgc caccaccgcc gctgctatat agtttaggtt tctgaggttt     2880

gtgagcctgt cctgctttgc attcttcaaa accattcctg atagagtagc cgagggagag     2940

tcttggggcc aagaagggcc cagggtgggt caggcgtgtg cactgtggaa cagagctgag     3000

accccggccc cccttggact ggcacagggt cctacagagt cagaggaggc ctgagatttc     3060

gaatgggcag tgaatggcct cttctgccag ccacaggcag gatgctcctt gatcacggca     3120

tcccccggcg gtagtacagg gtgagcttgc aggagggtct gcaagtgcag acagcagctg     3180

gggccaaaga ggtgttaggt tcaaaggctg cgaagagaat aggctactgg aaaaccaaac     3240

ccaacagaat tcacgtccaa aaatccacat tctccatcgc ttctcagcct tttggctaag     3300

attaagtatt aaaaaaaaac caggctctgc caggcgcagt ggctcatgcc tataatcccg     3360

gcactttggg agtctgtggc aggaggattg cttgaggcca ggagtttgag accagcctgg     3420

gcaacatagc gagaccccat ctctacaaaa gattaaaaat tagctgcgtg tagtagcata     3480

tgcctttcaa cgtagctact caggaggctg aggtgggagg atcccttgag ccgaggagtt     3540

tgagtctgca gtgagctatg atcgcaccac tgcattccag accccatctc gaaaaaaaaa     3600

aaaaaaaaaa aaa                                                        3613


<210> 747
<211> 1953
<212> DNA
<213> Homo sapiens

<400> 747
ccggcgtttc cgtaggagcc gggcgggagt cgccggggct ccttcctgtg gtgcagcttc       60

gggtctcgga gtttggcccc tactctgacc ccaccccagc tccgctccgc cttgggttcc      120

ggcagaaccc gccttgcggt agccatggca gcaggctccg aggcgaccac tcctgtgatc      180

gttgcggctg gggctggagg ggaggaaggt gaacatgtca aaccttttaa gccagagaaa      240

gcaaaagaaa ttatcatgtc tttacaacaa cctgcaatct tctgtaacat ggtgtttgat      300

tggccagcac gacactggaa tgctaaatac ctttcgcagg tccttcatgg caagcagata      360

cgattcagaa tggggatgaa aagcatgagc acagttcctc agtttgaaac tacatgtaat      420

tacgtagaag ctacactcga agagtttctg acctggaact gtgaccagtc tagtatttct      480

ggaccattta gagattatga ccattccaag ttctgggctt atgctgacta taaatatttt      540

gtcagtctat ttgaagacaa gacagatctt ttccaggatg tgaaatggtc tgacttcggg      600

tttcctggaa gaaatggaca ggaaagtaca ttgtggattg gctccttggg agcccacaca      660

ccctgtcatc tggactccta tggttgtaac ttggtattcc aggtacaagg aaggaaacga      720

tggcatctct ttcctcctga agatactcct ttcctttatc caactagaat cccttatgaa      780

gaatctagtg tgttcagtaa aatcaatgtt gtcaatcctg atttaaagcg ttttcctcag      840

ttccggaaag ctcaaagaca tgcggttaca ctgagcccag gacaggttct ctttgttccc      900

agacactggt ggcattacgt agaatccatt gatcctgtca ctgtcagtat aaactcatgg      960

attgaactgg aagaggatca cctagcccgg gtagaagagg caatcacccg tatgcttgtg     1020

tgtgccctga aaactgcaga gaatccacaa aataccagag cctggttaaa ccccactgag     1080

gttgaggaaa cgtcccatgc agtcaactgt tgctacttaa atgcagctgt ttctgcattt     1140

tttgatcgct gcagaacatc tgaggtagta gaaatccaag cactgagaac agatggagag     1200

cacatgaaaa aggaagaatt aaatgtgtgc aaccacatgg aggtgggcca aacaggtagc     1260

cagaacttga ccacaggaac agacaaaccg gaggcagcaa gtccctttgg ccctgatctg     1320

gtccctgtag cacagaggtc cgaagaaccg ccttcagaaa gaggaggcat atttggaagt     1380

gatgggaaag actttgtgga caaggatgga gaacactttg gaaaattgca ttgtgccaag     1440

agacaacaaa taatgagcaa cagtgaaaat gcaattgagg aacagattgc ctcaaatact     1500

actacgactc ctcaaacatt catttctacg gatgacttgc tggactgctt ggtgaatcca     1560

caagtaacca ggatagtggc acaacttttg atacaaggaa gaagtttatg attcaagtgg     1620

aagatgactt ttaaaataat attttttaaa tatatatttt taagtagtat gactaaaata     1680

aagatgaacc agcaaaaggt cagtttgcac atttgtaaat gtatttatcc ttaccgaatt     1740

acatgtcagt ctgttgccac cttctttcat gcacattcct ctttggccaa actggctgct     1800

ctttgtttgt aagcttttgt tcctctctca tcccatactt ttagcctgtg tcaaatgtaa     1860

gtcccaagta tttccagcag gaagtaatgt cttcctcagc ctcaaccagg gaccaaccgg     1920

ctgcttactt ttgcaaataa aattttacta gaa                                  1953


<210> 748
<211> 1409
<212> DNA
<213> Homo sapiens

<400> 748
ccaaaccact atgcccacgc acgcacccac ccaaacagag cgttttctgg tccccgagct       60

cctcccgacc ccacccgctc ctacggcctc caaccggccc cccccaggtc tcgaccctct      120

cccccaggcc tcgaccctcc ccccccagcc gctctagccc cgcccggccg ctctagcctc      180

cgctcctctc gctggtggag gttcccgacc gcgctcgctc ccgcaactgg gggcacggca      240

gaggaggcag ggccgacggc ggtgggcggt gcgttgcgca ggctcgggcc tcccgctcgc      300

cgctgcgttg ggaccgcgca gcccggtgtg tgcagtggcc tcagggatcc ggaaagtcta      360

ggactgaact tctcctaaca tccagtaatg gggacctgga acctgggctt actagagtgc      420

cgcgcgtagg gctccaggtc gctggcttct gcgcttcctt cctctccaaa gttgagtatc      480

tcctatctgt gtcctcgtac atactgccgc ctgaggtgcc atggccccca agccgggggc      540

cgagtggagc acagccctgt cccatctggt gctgggagtg gtgtctctgc acgcagccgt      600

gagcacagcc gaggcaagtc gaggggctgc tgctggcttc ctgctccagg tcttggctgc      660

caccaccacg ctggccccag ggctgagcac acacgaagac tgccttgctg gagcctgggt      720

ggccaccgtc atcggccttc cccttctggc cttcgatttc cactgggtga atggggaccg      780

ctcctctgcc aacctgctcc tgggaggagg catggtgctg gcagtggctg gcggccacct      840

cggccctgag ggccgctctg tggctggtca ggcaatgctg ttggtggtcg cagtgaccat      900

cctcattgta gctgtcttca cggccaacac ttatgggatg tggggggggg cgatgctggg      960

tgtggcaggc ctcctgagcc ggctggagga ggacaggctg ctgctgctac cgaaggagga     1020

tgtctgtcgc tgggccttgg ctgtaggcag ctgggcttac tgccgggccc tgcatacaca     1080

gcgcctccag tgggagtgac agttggatac agccaggcag ggtttctgcc ctgccgaaca     1140

ctttccctcc cacctgcctg ctcctggcgc cttctcccta ggggtagact cttctgccta     1200

ctgaagtggg tttgctgcac attgactggt caggggcaga gtctgggtgc tgtcctttgg     1260

ccacgtgtgg ggacttgtct agaccagaat gaaagggaca gggtcccaga cacgtttggg     1320

ggtcctgatt ctgggctgga cacggttgtg gatccagaga agaggcctag tctccaataa     1380

atcttaggaa ttttgcagga atatgaaaa                                       1409


<210> 749
<211> 2777
<212> DNA
<213> Homo sapiens

<400> 749
tcagcagctg ccctcactgg gcagggcaaa ttataccgtg gcccgaccat aaaagccact       60

ttccaaaaaa agaagcttta aggcccccga gagacgcagc tgagcctctc acctggcagt      120

gcctgactca ggaggtgatg tctgggccat gagccacaga gcctggtgtc cctttaagca      180

gggagtacaa attctcatcc ctccctcctg ctctccctga cgtcagctgg aaggcgtgtg      240

agtgagtgag gggctgaggt accgcccgcg cgagcacaca cagacacaca cacacacaca      300

cacacacaca cacacacaca tcttccagac ccatcccctg cctgccagct ccacgagcca      360

gagagagaca gagcgcggac gccgcaggag gcagtgcctg gaccccagct gcccaggaga      420

gacggagccc gtggctggtg aggccgcaga gcagggccag gccgggccct gcccgcaagg      480

acgaccaaac ccctcaccgg cccctgggcc ccagagccca ccaggctctc ctgctggccc      540

caccatgact tcagagtcga cgtcaccccc agttgtgccc ccgctccact cccccaagtc      600

cccagtctgg cccaccttcc ccttccacag ggagggcagc agggtctggg agcggggtgg      660

tgtcccacct cgggacctac ccagccctct gcccaccaag cggaccagga cctattcagc      720

gacagcccgg gcctcagctg gccccgtgtt caagggcgtc tgtaagcagt tctcacgctc      780

acagggccat ggcttcatca cccccgagaa cgggtccgag gacatcttcg tacatgtgtc      840

tgacatcgag ggggagtacg tgccagtgga gggcgacgag gtgacctaca agatgtgccc      900

tatccctccc aagaaccaga agttccaggc cgtggaggtg gtgctcactc agctggcccc      960

ccacactccc cacgagacgt ggtctggcca ggtcgtgggc tcctaggctg agtggttcac     1020

aggccagctg gccgggggtt ggggagccac acagggtgaa cgggcagcag ccggctccat     1080

gccccactgc cctggctgat gagtccttcg gtggcctcag tgtgcacgtc tgtctgtccg     1140

tctgtgcttg tggctatgag cgtgtgcctc cacccacccc acgacccgtg actactgtgc     1200

aagctggcca ggaggtaggt ggagggcaag gccaccagac ctggcttcgc gctgtccact     1260

gcctctctcc tcccctccct gccgcagaca cgcaggaccc gctcgccctc ctgcttaccc     1320

gtccccacgg tgactgagct gcgagagcct gcgctgggct cactccctgg cctccgcccc     1380

tgagctgtcc cgtgtcagtc cctggcccgg agccaggctc tctgtgctac ttacatctcc     1440

ctcccttggc tgaggtcccc cgccacagcc tggacccttc cctcagaagc ctggccgatg     1500

ggtgcttttg gggagcctct cagcctctgg caggggagga ggactgacac ggaggcacac     1560

aggcctctca ctgccgaggc cagccttcct tcctgctctg ctctctcagt gccatggaga     1620

ggcaggaaga ggggcctgag ggcggaaggg gtttggggct cccatttcgc cggccagtcc     1680

ctcctcctca gcctggcagt ggcgctgggc tccttcccct gggctgtact gagccgagcc     1740

caggggtttg cagagggtgg gggtccatct ctccagcttg gctgcagacc tcctttaccc     1800

tgactcacaa gccccactga tgctctgggc catgcccggc tgacggctgc tgtggatgcc     1860

gcgagggacg gacacacgtc cggggcaccc acgaggaggg cccccagcct gggagactgg     1920

ccctgcggcc tccacgtcaa actctcttcc caaagcccta acagaccagt ggccgaggtg     1980

tggctcttat tgcatccatc cctgaagatg tgtggctgtt gctgtcacct ggagtccttt     2040

tggggccaag atgtgtgtgc acccggggtc gtggccattc actcccaggc aggggtgagg     2100

gtggcctggc ccaggaggcc aggaaggagg gccctgtctg cctccacctc tgggtgcacc     2160

ccctgcctac caccctccct tctagagagc acatcgcctg accggggaga agtggggccg     2220

tggttcgagg gagggctggc caggggtggg acccttatga gactcagtct gtgagtaaaa     2280

ctgggggctc aaatgcccag gatgagggga tcagtgactg tctaggagga tcccttgcct     2340

tgtaggtgcc ccaagaccgc agggtagaaa tcagccggga tgcctgcatc ccacccccgg     2400

ccccagggcc caccacataa aatctgggag cccagagctg ctgaggtgtg gtcagctccc     2460

ctaaaatggg cacggcccag cctgtcccat gaggaataaa ggcccctggc ccccttgaga     2520

gagggcttgt tggtgagggc tgactcctgg gggcccccaa ggctcccctc ctgtggggag     2580

gccacctttt aaggcaccac tagcagtcag gatatggtgg catcagccct ggggcctcct     2640

gggtggcagg ggggcagcag ctctcctccc cactcacagg ccctgcagtg ctcatttgga     2700

attcctccca agacccctgg ccacccagac cccccattct tcctaacact ggcaataaac     2760

cctcaactgt gacccac                                                    2777


<210> 750
<211> 1086
<212> DNA
<213> Homo sapiens

<400> 750
gtttaggtcg gctggaaatt atgtcctccg tcggttttcc gcagtttttc caccaagcga       60

gatatttttg ggagttattc cctaaataac tgcattatat gctcctttca tgacgaaatt      120

gctgccgtgg agaagactgg aggaaactcg aggaagaggg agaagccgac aagtgctcga      180

cgggctagga actgtcctgc ttgggtgtta gcgtttcccg ccgggccagt aaggctgagt      240

gacccggcgt ggctactagg agaaggacgt acggtcctgc tagtagagga atatgtcgag      300

tttctctagg gcgccccagc aatgggccac ttttgctaga atatggtatc tcttagatgg      360

gaaaatgcag ccacctggca aacttgctgc tatggcatct ataagacttc agggattaca      420

taaacctgtg taccatgcac tgagtgactg tggggatcat gttgttataa tgaacacaag      480

acacattgca ttttctggaa acaaatggga acaaaaagta tactcttcgc atactggcta      540

cccaggtgga tttagacaag taacagctgc tcagcttcac ctgagggatc cagtggcaat      600

tgtaaaacta gctatttatg gcatgctgcc aaaaaacctt cacagaagaa caatgatgga      660

aaggttgcat ctttttccag atgagtatat tccagaagat attcttaaga atttagtaga      720

ggagcttcct caaccacgaa aaatacctaa acgtctagat gagtacacac aagaagaaat      780

agacgccttc ccaagattgt ggactccacc tgaagattat cggctataag agaataagaa      840

ttgcagaaaa taacagtgaa gtgattgaaa ctttcttctg atgagtttct ctaacctaca      900

ggatggagta aaacaactgc tacagttcag cacctgtttt atgtgccgaa tcactgtggg      960

gaaaggtcag gaaggtatag tccttcaata ggaaattgta attaaaatat aattttatag     1020

aaccattttt atgtaatctg atttgaatgt tatagttgat aataataaaa tcacttactt     1080

ggttga                                                                1086


<210> 751
<211> 9829
<212> DNA
<213> Homo sapiens

<400> 751
aaacaagatg gcggctgaag gcgatccgga gtggggcccc agcaattcgg attgagcctt       60

ctccctccac ccgcttccgt cggccgggcc cctcccgccc ggccccgcgg gcctccccac      120

ccggccccgg cgctccccac cgccccccct gcgcccgccc ctcccccttc gctttccttc      180

tccccccgcc tcggctccga catgaggggc cggcggggca ggccgcccaa gcagcccgcg      240

gctcccgctg cggagcgctg cgccccggcc ccgccgccac cgccgccgcc gcccacgtcc      300

ggacccatcg gggggctccg ctcgcggcac cgcggcagca gccggggcag gtgggccgcc      360

gcccaggctg aggtggcgcc caagacgcgg ctgagctcgc ccaggggggg cagcagtagc      420

cggaggaagc cgccgccgcc gccgccggcc ccccccagca ccagcgcccc gggccggggg      480

gggcgaggag gcgggggcgg caggacgggg ggcgggggcg gcggcggcca cctggcccgg      540

accaccgcgg cccggagggc cgtcaacaaa gtggtgtacg atgaccacga gagcgaggag      600

gaggaggaag aggaggacat ggtctccgag gaggaggagg aggaggacgg cgacgccgag      660

gagacccagg attctgagga cgacgaggag gatgagatgg aagaggacga cgatgactcc      720

gattatccgg aggagatgga agacgacgac gacgacgcca gttactgcac ggaaagcagc      780

ttcaggagcc atagtaccta cagcagcact ccaggtaggc gaaaaccaag agtacatcgg      840

cctcgttctc ctatattgga agaaaaagac atcccgcccc ttgaatttcc caagtcctct      900

gaggatttaa tggtgcctaa tgagcatata atgaatgtca ttgccattta cgaggtactg      960

cggaactttg gcactgtttt gagattatct ccttttcgct ttgaggactt ttgtgcagct     1020

ctggtgagcc aagagcagtg cacactcatg gcagagatgc atgttgtgct tttgaaagca     1080

gttctgcgtg aagaagacac ttccaatact acctttggac ctgctgatct gaaagatagc     1140

gttaattcca cactgtattt catagatggg atgacgtggc cagaggtgct gcgggtgtac     1200

tgtgagagtg ataaggagta ccatcacgtt cttccttacc aagaggcaga ggactaccca     1260

tatggaccag tagagaacaa gatcaaagtt ctacagtttc tagtcgatca gtttcttaca     1320

acaaatattg ctcgagagga attgatgtct gaaggggtga tacagtatga tgaccattgt     1380

agggtttgtc acaaacttgg ggatttgctt tgctgtgaga catgttcagc agtataccat     1440

ttggaatgtg tgaagccacc tcttgaggag gtgccagagg acgagtggca gtgtgaagtc     1500

tgtgtagcac acaaggtgcc tggtgtgact gactgtgttg ctgaaatcca aaaaaataaa     1560

ccatatattc gacatgaacc tattggatat gatagaagtc ggaggaaata ctggttcttg     1620

aaccgaagac tcataataga agaagataca gaaaatgaaa atgaaaagaa aatttggtat     1680

tacagcacaa aggtccaact tgcagaatta attgactgtc tagacaaaga ttattgggaa     1740

gcagaactct gcaaaattct agaagaaatg cgtgaagaaa tccaccgaca catggacata     1800

actgaagacc tgaccaataa ggctcggggc agtaacaaat cctttctggc ggcagctaat     1860

gaagaaattt tggaatccat aagagccaaa aagggagaca ttgataatgt taaaagccca     1920

gaagaaacag aaaaagacaa gaatgagact gagaatgact ctaaagatgc tgagaaaaac     1980

agagaagaat ttgaagacca gtcccttgaa aaagacagtg acgacaaaac accagatgat     2040

gaccctgagc aaggaaaatc tgaggtaggt gatttcaaat cggagaagtc caacggggag     2100

ctaagtgaat ctcctggagc tggaaaagga gcatctggct caactcgaat catcaccaga     2160

ttgcggaatc cagatagcaa acttagtcag ctgaagagcc agcaggtggc agccgctgca     2220

catgaagcaa ataaattatt taaggagggc aaagaggtac tggtagttaa ctctcaagga     2280

gaaatttcac ggttgagcac caaaaaggaa gtgatcatga aaggaaatat caacaattat     2340

tttaaattgg gtcaagaagg gaagtatcgc gtctaccaca atcaatactc caccaattca     2400

tttgctttga ataagcacca gcacagagaa gaccatgata agagaaggca tcttgcacat     2460

aagttctgtc tgactccagc aggagagttc aaatggaacg gttctgtcca tgggtccaaa     2520

gttcttacca tatctactct gagactgact atcacccaat tagaaaacaa catcccttca     2580

tcctttcttc atcccaactg ggcatcacat agggcaaatt ggatcaaggc agttcagatg     2640

tgtagcaaac ccagagaatt tgcattggct ttagccattt tggagtgtgc agttaaacca     2700

gttgtgatgc taccaatatg gcgagaatct ttaggacata ccaggttaca ccggatgaca     2760

tcaattgaaa gagaagaaaa ggagaaagtc aaaaaaaaag agaagaaaca ggaagaagaa     2820

gaaacgatgc agcaagcgac atgggtaaaa tacacatttc cagttaagca tcaggtttgg     2880

aaacaaaaag gtgaagagta cagagtgaca ggatatggtg gttggagctg gattagtaaa     2940

actcatgttt ataggtttgt tcctaaattg ccaggcaata ctaatgtgaa ttacagaaag     3000

tcgttagaag gaaccaaaaa taatatggat gaaaatatgg atgagtcaga taaaagaaaa     3060

tgttcacgaa gtccaaaaaa aataaaaata gagcctgatt ctgaaaaaga tgaggtaaaa     3120

ggttcagatg ctgcaaaagg agcagaccaa aatgaaatgg atatctcaaa gattactgag     3180

aagaaggacc aagatgtgaa ggagctctta gattctgaca gtgataaacc ctgcaaggaa     3240

gaaccaatgg aagtagacga tgacatgaaa acagagtcac atgtaaattg tcaggagagt     3300

tctcaagtag atgtggtcaa tgttagtgag ggttttcatc taaggactag ttacaaaaag     3360

aaaacaaaat catccaaact agatggactt cttgaaagga gaattaaaca gtttacactg     3420

gaagaaaaac agcgactcga aaaaatcaag ttggagggtg gaattaaggg tataggaaag     3480

acttctacaa attcttcaaa aaatctctct gaatcaccag taataacgaa agcaaaagaa     3540

gggtgtcaga gtgactcgat gagacaagaa cagagcccaa atgcaaataa tgatcaacct     3600

gaggacttga ttcagggatg ttcagaaagt gattcctcag ttcttagaat gagtgatcct     3660

agtcatacca caaacaaact ttatccaaaa gatcgagtgt tagatgatgt ctccattcgg     3720

agcccagaaa caaaatgtcc gaaacaaaat tccattgaaa atgacataga agaaaaagtc     3780

tctgaccttg ccagtagagg ccaggaaccc agtaagagta aaacaaaagg aaatgatttt     3840

ttcatcgatg actctaaact agccagtgca gatgatattg gtactttgat ctgtaagaac     3900

aaaaaaccgc tcatacagga ggaaagtgac accattgttt cttcttccaa gagtgcttta     3960

cattcatcag tgcctaaaag taccaatgac agagatgcca cacctctgtc aagagcaatg     4020

gactttgaag gaaaactggg atgtgactct gaatctaata gcactttgga aaatagttct     4080

gataccgtgt ctattcagga tagcagtgaa gaagatatga ttgttcagaa tagcaatgaa     4140

agcatttctg aacagttcag aactcgagaa caagatgttg aagtcttgga gccgttaaag     4200

tgtgagttgg tttctggtga gtccactgga aactgtgagg acaggctgcc ggtcaagggg     4260

actgaagcaa atggtaaaaa accaagtcag cagaagaaat tagaggagag accagttaat     4320

aaatgtagtg atcaaataaa gctaaaaaat accactgaca aaaagaataa tgaaaatcga     4380

gagtctgaaa agaaaggaca gagaacaagt acatttcaaa taaatggaaa agataataaa     4440

cccaaaatat atttgaaagg tgaatgcttg aaagaaattt ctgagagtag agtagtaagt     4500

ggtaatgttg aaccaaaggt taataatata aataaaataa tccctgagaa tgatattaaa     4560

tcattgactg ttaaagaatc tgctataagg ccattcatta atggtgatgt catcatggaa     4620

gattttaatg aaagaaacag ctccgaaaca aaatcgcatt tgctgagttc ttcagatgct     4680

gaaggtaact accgagatag ccttgagacc ctgccatcaa ccaaagagtc tgacagtaca     4740

cagacgacca caccctcagc atcttgtcca gaaagcaatt cagttaatca ggtagaagat     4800

atggaaatag aaacctcaga agttaagaaa gttacttcat cacctattac ttctgaagag     4860

gaatctaatc tcagtaatga ctttattgat gaaaatggtc tgcccatcaa caaaaatgaa     4920

aatgtcaatg gagaatctaa aagaaaaacc gtcatcacag aagtcaccac gatgacctcc     4980

acagtggcca cagaatcaaa aactgtgatc aaggtagaaa aaggcgataa gcaaactgtg     5040

gtttcttcca cagaaaattg tgcaaaatcc actgtcacaa ccaccactac aacagtgacc     5100

aagctttcca caccctccac aggcggcagt gtggacatca tctctgtaaa ggagcagagc     5160

aaaaccgtgg tcaccacgac agtgacagac tccctgacca ccacgggagg cacactggtt     5220

acatctatga ctgtgagcaa agagtattcc acacgagaca aagtgaaact gatgaaattt     5280

tcaagaccaa agaagactcg ttcaggtaca gctctgccat cctatagaaa atttgttacc     5340

aagagcagca agaagagcat ttttgttttg cctaatgatg acttaaaaaa gttggcccga     5400

aaaggaggaa tccgagaggt cccttatttt aattacaatg caaaacctgc tttggatata     5460

tggccatatc cttctcctag accgaccttt ggcatcactt ggaggtatag acttcagaca     5520

gtaaagtcct tagctggagt gagcctgatg ttacggttac tgtgggcaag tttgagatgg     5580

gatgatatgg cggccaaggc tcctccagga ggagggacta cacggacaga aacatccgaa     5640

actgaaatca caacaacaga aataattaag aggagagatg ttggtcctta tggcattcga     5700

tctgaatatt gtatcaggaa aatcatttgt cccattggag ttccagaaac accaaaagaa     5760

acgcctacac ctcagaggaa aggccttcga tcaagtgcac tgcggccaaa gagaccagaa     5820

acgcccaagc aaactggccc tgttattatt gaaacctggg tagcagaaga agaactggaa     5880

ttgtgggaga tcagggcatt tgctgagaga gtggagaaag aaaaggcaca agcagttgag     5940

caacaggcta agaaacgact ggagcagcag aagccgacag tgattgcaac ttccactact     6000

tccccaacaa gcagtacaac cagcaccatc tctccagcac agaaggttat ggtggccccc     6060

ataagtggct cagttacaac tggaaccaaa atggtactaa ctactaaagt tggatctcca     6120

gctacagtaa cattccaaca aaacaagaac tttcatcaaa cctttgctac atgggttaag     6180

caaggccagt caaattcagg cgttgttcaa gtacagcaga aagtcctggg tatcattcca     6240

tcaagtacag gtaccagtca gcaaaccttt acttcattcc agcccaggac agcaacagtc     6300

acaattaggc ccaatacctc aggctctgga ggaaccacaa gcaattcaca agtaatcaca     6360

gggcctcaga ttcgccctgg tatgaccgtg attagaacac cactccaaca gtcaacacta     6420

ggaaaggcaa ttattcgaac acctgtgatg gtacagccag gtgctcctca gcaagtgatg     6480

actcaaatca tcagggggca gcctgtctcc actgcagtct ccgcccctaa cacggtttcc     6540

tcaacacctg ggcagaaaag cttaacttca gcaacgtcca cttcaaatat acagtcttca     6600

gcctcacaac cccctcgccc ccaacaagga caagtgaagc tcaccatggc tcaacttact     6660

cagttaacac agggccacgg tggcaatcaa ggtttgacag tagtaattca aggacaaggt     6720

caaactactg gacagttgca gttgatacct caaggggtga ctgtactccc aggcccaggc     6780

cagcagctaa tgcaagctgc aatgccaaat ggtactgttc agcgattcct ctttacccca     6840

ttggcaacaa cagccaccac agccagcacc accaccacca ctgtttccac gacagcagca     6900

ggtacaggtg aacaaaggca gagtaaactg tcaccccaga tgcaggtaca tcaagacaaa     6960

accctgccac cagctcagtc atcaagtgtg ggtccagcag aagcccagcc acagactgct     7020

cagccttcag ctcagcccca gccccaaacc cagccccagt ccccagctca gcctgaagtt     7080

cagactcagc ctgaagttca gacccaaaca actgtttcat cccatgtccc ttctgaagca     7140

caacccaccc acgcacagtc atccaagccc caagttgcag cacagtctca gcctcaaagt     7200

aatgtccaag gacagtctcc tgttcgtgtc caaagtccat cacagactcg aatacgtcca     7260

tcaactccat cccaactgtc tcctggacaa caatcccagg ttcagactac aacctcacaa     7320

ccgattccaa ttcaaccaca tacatctctt cagatacctt cccaaggcca gccacagtca     7380

caaccccagg tacagtcttc aactcaaact ctttcatcag gacaaacttt aaatcaagtt     7440

actgtttcat ccccatcccg tcctcagcta caaatacagc agccacagcc ccaagtcatt     7500

gctgtgcctc agctgcaaca acaagtccag gttctctctc agatccagtc acaggttgtg     7560

gctcagatac aggctcagca aagtggtgtg ccccagcaaa tcaaactcca gttacctatc     7620

caaattcagc aaagcagtgc tgtgcagact caccagattc agaatgtggt tacagtgcag     7680

gcagccagtg tgcaagagca gttgcaaagg gttcagcaac tcagggatca gcagcaaaag     7740

aagaaacagc aacagataga aattaagcgt gaacacaccc tccaagcttc taatcaaagt     7800

gaaatcattc agaaacaggt ggtgatgaag cataatgctg taatagaaca tttaaaacag     7860

aaaaagagca tgactccagc tgaaagagaa gagaatcaaa gaatgattgt ctgtaaccag     7920

gtgatgaagt atattttgga taagatagat aaagaagaaa aacaggcagc aaaaaaacgg     7980

aagcgtgaag agagtgtgga gcagaaacgt agcaagcaga atgccactaa gctgtcagct     8040

ctgctcttca agcacaaaga gcagctcaga gccgagatcc tgaagaagag agcactcctg     8100

gacaaggatc tgcaaattga agtgcaggaa gagctgaaga gagacctgaa aattaagaaa     8160

gaaaaagacc tgatgcagtt ggctcaggcc acagcagtag ctgcaccctg ccccccagtg     8220

acaccagctc ctccagcccc tccagcccct ccaccttcac ctccccctcc acctgctgtg     8280

caacacacag gccttctgtc cacgcccacc ttacctgctg cttcccagaa gaggaagcgg     8340

gaagaggaaa aagactccag ctcaaagtcc aagaaaaaga aaatgatctc tactacctca     8400

aaggaaacta agaaggacac aaagctttac tgtatctgta aaacgcctta tgatgaatct     8460

aaattttata ttggctgtga tcggtgtcag aattggtacc atgggcgctg cgttggcatc     8520

ttgcaaagtg aggcagagct cattgatgag tatgtctgtc cacagtgcca gtcaacagag     8580

gatgccatga cagtgctcac gccactaaca gagaaggatt atgaggggtt gaagagggtg     8640

ctccgttcct tacaggccca taagatggcc tggcctttcc ttgaaccagt agaccctaat     8700

gatgcaccag attattatgg tgttattaag gaacctatgg accttgccac catggaagaa     8760

agagtacaaa gacgatatta tgaaaagctg acggaatttg tggcagatat gaccaaaatt     8820

tttgataact gtcgttacta caatccaagt gactccccat tttaccagtg tgcagaagtt     8880

ctcgaatcat tctttgtaca gaaattgaaa ggcttcaaag ctagcaggtc tcataacaac     8940

aaactgcagt ctacagcttc ttaaagttca gcgtgttaac ctaacataaa acacagcaag     9000

aatctggttg tctgaactat tttaaattaa ggagccagat gtttttagtc aggctatcct     9060

gacaagactt gacctaaact tcgtttttat tggtcataac agtccaatta tattcttggc     9120

caattttgtc caacggacaa gaaaaaagca aagtcaacga caccattatc ttgtcaagat     9180

cagatggttt tactattgtg gcagaagcga gaaaactttg tttattgaaa aaaaaagaaa     9240

aagaaagcaa gaaaaaaaga tactatgggg tcaagtgtaa ctccatggaa atgccacgtc     9300

tgctcttcag tgaagaagct ggtttagagt ctcacagaaa acttttgact gtatttattt     9360

attgttgcaa aaaagacgct tttttattgc tgccctcatt tgtcagctaa ttattttttc     9420

ttataaaatc cagccccggt tacatataat catctgtatc ttatcatgat tcctgtaggt     9480

aaaagtacaa gacgacctct agatgtcttt tctttctatg aaaggagctg ctatgtacac     9540

atgtgcacac acacacaact gggaatcaac aatgagttta ttgttcatgg tagattaaaa     9600

ttaagcttgc ataaaggttg ggctaagtgg tcctggacta cagactctgt tgccttgaat     9660

ataacagtac aatttgtcaa ttactctgca ccaggctaaa atgagtaaaa tctatttgaa     9720

ggtatcttgt ttgtaaacat ttgtcagatt ctaatttttt tcttttgtat taaaattcaa     9780

ctatggatgt atatgaaaca aaataaatgg agataatttt tctcccaca                 9829


<210> 752
<211> 2301
<212> DNA
<213> Homo sapiens

<400> 752
gcccctcctt ctcgcggcgc tcgagggacc atggccgatc ctcgcgtgag acagatcaag       60

atcaagaccg gcgtggtgaa gcggttggtc aaagaaaaag tgatgtatga aaaagaggca      120

aaacaacaag aagaaaagat tgaaaaaatg agagctgaag acggtgaaaa ttatgacatt      180

aaaaagcagg cagagatcct acaagaatcc aggatgatga tcccagattg ccagcgcagg      240

ttggaagccg catatttgga tcttcaacgg atactagtaa gcaaagactt ctgtgtcatg      300

tttaaatttt ttttttcaat ccaatacatg gaaagccaaa agtttaaata tttaacactg      360

agaactagtt ggcagtattt cttattcact tgccctttat accgctatat tttaaaataa      420

ttaatggagt ttaaattgtg ttttgaatta tgcctccagt aaaagtactg ttttctagca      480

tgtttgttca gtttattaaa atttagctag ttaaatttat ttaagttatg atagtaccag      540

tattgtccag caatgtcttg attatttggt tttcatacat aaagatcttt tgagacattg      600

aggatgagtt gactgattaa aattttaaaa gatctaatgt ttcaaaagaa tttgggatct      660

tattaaaagg atcttgaatt ctttcacatt caaacctaga tcagtttgag agggggaaaa      720

aacctggtaa tctatgtagt cccctcatac taacttggag ctgaataaca cttatacttg      780

ctggtataaa tgccttgtga tacagaaggt agataaagca ggaaataata actgttaaaa      840

tactatctaa gacaggaagc atcatttgta tttcttgaca gtttaaatgc ttttttctct      900

catgaatcta gtagctgaga aagtaataga aattgcttgg aaaaaaataa tgttggccgc      960

caggtgcagt ggctcatgcc tgtaatccca gcactttggg aggctgaggt gggtggatca     1020

cgagtcagga gttcaagacc agcctgacca acatggtgaa atcctgtctc tactaaaaat     1080

accaaaataa taataataat aataatgtat ttggatgata tatttgtatg tgaagatgta     1140

ttcaacaata tctctgccct tgaagagctt gtatttacta acagagaaca aagatgtgtt     1200

taaggtataa catggaggtt taagaaattc ttacgtatag tttgagctaa gcaaattctc     1260

agtcgttttg ctttcagttt tcatattaaa tacacacata ctttatttcc tctactgttt     1320

gtatatctcc atcttttatt gacctgacat aaattgctaa ccatagcttc atttaaaaat     1380

caaacaaaat ttcctgtgta ctttagataa tattatttca tttgtctgtt atcattacaa     1440

tatattagta aaagttgcct gtatatcagt attatggaaa aactcaatct ttaaatatca     1500

gaaaatgaaa gatgtatttt gtttccttta gtgtagggta tgtaataccc attagcaagc     1560

aggcaattca tttgtttaat tcaaagatta tatttaactc tgttgtgaca tcagaagcct     1620

tctttgtcat tgtgaatagt cagtggatta ttttggcctg aatgctgtca tatatgtaac     1680

atgttagtaa atcttccttt ttacttttct cttttgtatg atgatgatgg gtcaacaaaa     1740

tgagaataaa ctttttctga ggtttttatt taattaatgc tggtagcttt agaagactgt     1800

tattcactta ttttatgaga atatatacag tgaaacaaaa ccaccagtta tttcttcctt     1860

tccttgtaaa gaaggaacag aatgtgggaa acctgtggaa ttacaatata tttagatgag     1920

gcttgggatt ttttactttt aattttttag ttattaacat taatggtttg taatatttga     1980

gtaaataaca aagtactgaa acttgaaaag gataaactta atttttattg tatttcattt     2040

taggaaaatg aaaaagactt ggaagaagct gaggaatata aagaagcacg tttagtactg     2100

gattcagtga agttagaagc ctgaaacttt tctcgtatgg ggtggttttt gcattaaatc     2160

ctggggtcca ttttacaatc cattattttt gaccactgct atgtgttcaa gtagtatgag     2220

aatgtgattg tttttatctg gttacatata tatttctttg tctaatttaa tatgtcaaat     2280

aaatgagttc atctaataaa a                                               2301


<210> 753
<211> 1511
<212> DNA
<213> Homo sapiens

<400> 753
ggcggcggcg gaggagtggt gtgtgtgcga gcgtgtgtgg ctgggggaag ccattgcctg       60

tttaatagtt gctgttgctg cacttccgct tctctcccag cgagagagag acacgagtgg      120

ccaggcccag ccgcagccgc agcagcagcc gccgcggcgg cacggaggag ccagacacaa      180

agagaggggc tgtttgcggg gtggggtggg gggttcgcta tgtcggatga cgattcgagg      240

gccagcacca gctcctcctc atcttcgtct tccaaccagc aaaccgagaa agaaacaaac      300

acccccaaga agaaggagag taaagtcagc atgagcaaaa actccaaact cctctccacc      360

agcgccaaga gaattcagaa ggagctggcg gacatcactt tagaccctcc acctaattgc      420

agtgctggtc ccaaaggcga taacatctat gaatggagat caaccattct agggcctcca      480

ggatccgtgt atgagggtgg tgtattcttt ctcgatatca cttttacacc agaatatccc      540

ttcaagcctc caaaggttac atttcggaca agaatctatc attgtaatat taacagtcaa      600

ggtgttattt gcttggacat attgaaagat aattggagtc cagcactaac catttctaaa      660

gtcctccttt ctatctgctc acttcttaca gactgtaatc ctgccgaccc cttggtggga      720

agtattgcca ctcagtatat gaccaacaga gcagaacatg acagaatggc cagacagtgg      780

accaagagat acgctacata aattggggtt tcacaattct tacattattt gtctgtcaca      840

gaagagagct gcttatgatt ttgaaggggt cagggagggt gggagttggt aaagagtagg      900

gtatttctat aacagatatt attcagtctt atttcctaag attttgttgt aacttaaggt      960

atcttgctac agtagacaga attggtaata gcaactttta aaattgtcat tagttctgca     1020

atattagctg aaatgtagta cagaaaagaa tgtacattta gacatttggg ttcagttgct     1080

tgtagtctgt aaatttaaaa cagcttaatt tggtacaggt tacacatatg gccatttatg     1140

taaagtccct ctaagactac atactttttg tttaaaacaa aattggaatt tgttttccct     1200

tcttggaagg gaacattgat atttaacaga gtttttagag attgtcatct catatatata     1260

aaatggacac gtggctataa aacaccatat aagagatgag tagtgcgttt tattttatat     1320

gccaatctac tttgtttaaa aaaggtctga atcaggactt gtgaaaacct gtagtgaaat     1380

accttaagct gttaactaac tgtaaggcgt ggaataggag ttgctcagtg gattggttct     1440

atgttgtgga ctacttaagt ctgcatttgt tactgtgcta ataaacaata ttaaaaacca     1500

cctaataaac a                                                          1511


<210> 754
<211> 2076
<212> DNA
<213> Homo sapiens

<400> 754
atgatattct gttctcttgg gacattacag ttttgcatag acaaggtgaa catttctcaa       60

aacaccatgt ctctccaatt ttctaatgga tccaggcatg tttgcttaag gtctggagct      120

ggatctgtca gacccctcaa tggaggtgca ggctttgcag gcagcagtgc atgtggtggc      180

tctgttgctg gaagtgaatt ttcctgtgcc ttgggagggg gcttgggcag tgttcctggt      240

gggagccatg ctggtggtgc ccttggaaat gctgcttgta ttggctttgc tggaagcgaa      300

gggggactcc tctctggaaa tgagaaggtg accatgcaaa atcttaatga ccgcttggca      360

tcctacctgg ataatgtgcg agctctggag gaggcaaatg ctgaattaga gagaaaaatc      420

aagggttggt atgaaaaata cggacctgga tcttgccgtg gacttgatca tgactatagc      480

agatatcacc taacaattga ggatcttaag aataagatta tctcctccac tactactaat      540

gctaatgtca ttctgcagat tgataatgcc agactggctg ctgatgattt caggctaaag      600

tatgaaaatg agctcaccct tcaccaaaac gtagaggccg acatcaacgg attacggcga      660

gtcctggacg agctgacgct ctgcaggacc gaccaggagc tgcaatatga gtctctgagt      720

gaggagatga catatctcaa aaagaaccac gaagaggaga tgaaggctct gcagtgcgcg      780

gctgggggca acgtgaacgt ggagatgaac gcggccccgg gggtagacct cgcggttttg      840

ttgaacaaca tgcgagcgga gtacgaagcc cttgcagagc agaaccgcaa ggacgcggag      900

gcctggttca atgagaagag cgcctcgctg cagcaacaga tctcccacga ctcaggcgca      960

gccactttcg cccggagcca gctcaccgag atgaggcgca ccctgcagac cctggagatc     1020

cagctgcagt ccctgatggc cacgaaacac tccctggagt gctccttgac agagaccgag     1080

agcaactact gtacgcagct ggcgcagatc caggctcaga tcggggccct ggaggagcag     1140

ctgcaccagg tcagaaccga gaccgagggc cagaagctgg agtatgagca tctcctcgat     1200

gtcaaggtcc acttggaaaa agaaattgag acctactgcc gcctgataga tggagatgga     1260

aattcatgct ccaaatcaaa gggctttgga tcaggaagcc ctgggaattc atctaaagat     1320

ttatccaaaa ccacactggt aaagacagtg gttgaagagc tagatcaacg tggtaaagtt     1380

ctttcatcaa ggattcactc cattgaagaa aagacatcta aaatgaccaa cggcaagaca     1440

gaacaaaggg ttcctttcta gctgtcattt tagagaaaag aataatttgg gaaaggatcc     1500

tgtacaattg cattattcta aatatcagag agaatataca cactttttac ttttaaagat     1560

acattactta gcaaaaatac ctgttttctt agttttacag gatattgagt gtttgtttcc     1620

aataaataaa aaagttgatg tgcattcatt tccattcact gatgactaat aaataactat     1680

ttgtgatttt tttctatgtc tcattcatag agaaacactt gtggaatata ttttaattgc     1740

ctttcactgt tgttttaaat aatagtcaat accgccacat ggcatttgaa tatgaaacat     1800

tcactatgca taatctttaa atcacatcgt gtctatgtgg gcaaataatc aaaaacttca     1860

gaaattctcc tgtgactgaa aagtctcacc actagatgac gcattcctgg tattttacca     1920

agagcctctc tcaaactctt ctttccacaa tacccaggat accattcctc gtctaaacag     1980

gataatctcc ggaaaaatcc acagcaatat ggcttgtgtt agtgacactt ttcctagaac     2040

aggggtcaga agcttttttt gtgaagaccc agatag                               2076


<210> 755
<211> 2596
<212> DNA
<213> Homo sapiens

<400> 755
ctgcttcctg cacgggtggt ccccaagcac tgcggggccc cagcccaaag cggaccttga       60

ctaccgccca gccccgcgct cccaggacct cccgcccgcg gagcccactc ggattgctct      120

ccgcccgggt cggcggaggc cccgtctcct gtacccggcg ctgggactgc tccgcaccgc      180

gcggctccct ttcagcagct gcgggagcat gcggaggagg ccctgccggc cccgcgggtc      240

atggaggagt tccggcgctc ctacagccgc ctgtgcaggg agagtggggc cgagccccag      300

gaggctgtcc tgcagcagct gcaccagctt cccaggggcc ggctggacct ggccacgcaa      360

agcctgacgg tggagacctg cagggccctg ggcaagctgc tgccgaggga gacgctgtgc      420

acggagctgg tcctgagtga ctgcatgctc agcgaggaag gggccacact gctgctccga      480

ggcctgtgtg ccaacaccgt gctgcgcttt ctggacttaa agggcaacaa ccttcgggct      540

gcaggggccg aggctctggg aaaactcctc caacagaaca agtccattca gagcctcacg      600

ctggagtgga acagcctggg cacgtgggac gatgccttcg ccaccttctg cgggggcctg      660

gcggccaacg gcgccctgca gcggctggac ctccgcaaca accagatcag tcacaagggc      720

gcggaggagc tggccctagc cctgaagggc aacaccaccc tccagcagct ggacctgcgc      780

tggaataacg ttggcctcct ggggggccgg gccctcatga actgtctccc cagcaacaga      840

accctgtgga gactggacct ggctgggaac aacatccctg gagacgtcct cagagccgtg      900

gagcaagcca tgggccacag ccaggaccgg ctcaccacct tccaggagaa ccaagcccgc      960

actcacgtcc tcagcaagga ggtccagcac ctccgggagg agaagtccaa gcagttcctc     1020

gacttgatgg agactattga taagcagcga gaagagatgg ccaagagcag cagggcgtcg     1080

gcagcccgtg tagggcagct tcaggaagcc ctgaatgaga ggcactccat catcaacgct     1140

ctcaaggcca agctgcagat gacagaggcc gccctggctc tgtcggagca gaaggcccag     1200

gacctggggg agctcctggc cacagcggag caggagcagc tgagcctgtc acagaggcag     1260

gccaaggagc tcaagctgga gcagcaggaa gctgcagagc gggagtctaa actcctcaga     1320

gacttgtctg ctgccaatga aaagaacctg cttctgcaaa accaggtaga cgagttggag     1380

cggaagttca ggtgtcagca ggagcagctg ttccagacca ggcaggagat gaccagcatg     1440

tcagctgagc tgaagatgcg ggccatccag gccgaggagc gcctggacat ggagaagaga     1500

agatgcagac agagcctgga ggactccgaa agcctgcgca tcaaggaggt ggagcatatg     1560

acccgtcacc tggaggagag tgagaaggcc atgcaggagc gggtgcagag gctggaggcg     1620

gcgcggctgt ccctggagga ggagctgagc cgagtgaaag cagcggcact cagcgagcgt     1680

ggccaggctg aggaggagct gatcaaggcc aagagccagg cccgcctgga ggagcaacag     1740

cgcctggctc acctggagga caagctgaga ctgctggcgc aggcacggga cgaggcgcag     1800

ggcgcttgcc tacagcagaa gcaggtggtg gccgaggccc agacccgggt cagccagctg     1860

ggcctgcaag ttgagggcct gcggcggcgc ctggaagagc tgcagcagga gctgagcctc     1920

aaggaccagg aaagggtggc cgaggtgagc agggtgcgcg tggagctgca ggagcagaac     1980

ggccggctgc aggcggagct ggcggctcag gaggcgctga gggagaaggc ggcggccctg     2040

gagcgccagc tgaaagtgat ggcgagcgac caccgagagg cgctgctgga cagggagagc     2100

gagaacgcgt ctctccggga gaagctgcgg ctccgggagg cggagatcgc ccgcatccgg     2160

gacgaggagg cccagagggc gagcttcctg cagaacgccg tcctggctta cgtgcaggcg     2220

tcccccgtga ggaccctgag ccccccaaag tgagacaggc cgggaggacc cgggcgcagt     2280

aggagtgcat caggcggcgc ccgagatgga ccaggggctg cgtcccgccc gcgccgcctc     2340

tttgagaccc gggtcgtctg ttccacgcgg cggttgcggc gactgttggt ggtgtcgcgg     2400

ctgcggggga accccgtggg aggcgcctgg gaagggctcc ctaccggccc cttcttcccg     2460

gtcgacgcca cgtgggagca caccgggaag gggtcccgcg ggcgcgtctc cccctcgcct     2520

tttgcgatgt caccgtgaac gctgcggccg cctgcgcgcg gcggggtttg gaaatacagc     2580

gcgtttgcac tttgtg                                                     2596


<210> 756
<211> 3943
<212> DNA
<213> Homo sapiens

<400> 756
agcctggctg aggcagccgc gcaggtcgca gggccagcgt ccgcgaggac ggcccggctg       60

ggcggccccg agctctgtgg cgctgtggag gagcgggagc gcggccgagg aagcggggcg      120

ccgagggggt cggcggcctt cgggaaattt ccgccgaccc ttcgctcccg gctctaaaag      180

ttcctgattt cctatttcct tttaaatccc gagtggctgt tagctcttcg cctgcacttt      240

ttcttcccca ggagataagg gggagtgtga ggaacggagc gaataatata aaaaaggatt      300

tcctcccgga agagagcggc agttcggaga gatttttctt aaggaagcag aagcggcgtt      360

tgcggccgct gcaggcgccg ggccctgccg gccacactat gcgcgagccg gccccgggct      420

gctgaggcgc ggggacgcgg aagcggaggc cgagcgcgcc gggctcccgc gctcgcgagc      480

gagttttgtc cgcccggcgg cggtggcggg gggatggagc ccgcgaccgc gccccggccc      540

gacatggcgc cggagctgac cccggaggag gagcaggcta ccaagcagtt tctcgaagag      600

attaacaagt ggacagttca gtacaatgtt tccccgctgt cttggaatgt ggctgtcaag      660

ttcctcatgg caaggaagtt tgatgtgctc cgtgccatag aattgttcca ctcctacaga      720

gaaactcgaa ggaaggaagg cattgtaaag ctgaaacctc atgaggaacc tcttcgttct      780

gagatcctca gtggaaaatt caccatctta aatgttcggg acccaacagg agcctccatt      840

gccctcttta ctgccaggtt gcatcatccc cacaagtcag tccaacatgt ggtacttcag      900

gctctgtttt acttgctaga cagagctgtg gatagctttg aaactcagag gaatggactg      960

gtgtttatct atgacatgtg tggttctaat tatgccaact ttgagctgga tcttggcaag     1020

aaagtcctaa acctgctgaa gggagcattt ccagctcgtt tgaagaaggt gctgattgtg     1080

ggggcaccca tatggttccg agtgccctat tccatcatca gtctcctcct gaaggacaaa     1140

gtccgggaga ggattcaaat attaaagaca tctgaggtca cgcagcatct gcccagggag     1200

tgtcttccag aaaacctggg tgggtacgtc aaaattgatc tcgccacttg gaatttccag     1260

ttcctacccc aggtgaacgg ccacccagat cccttcgatg agatcatcct gttctccctc     1320

cctcctgcct tagactggga ctcagtacat gttccaggtc cccatgctat gaccatccaa     1380

gagttggtgg actatgttaa tgccaggcaa aagcaaggaa tctatgagga atatgaagac     1440

attcgtcgtg agaaccctgt tggcactttc cactgttcca tgtctccagg aaacctagag     1500

aaaaaccgtt atggggatgt accctgcctg gaccaaacta gagtgaagct aacaaagcga     1560

agtggccata ctcagacaga ttacatcaat gccagtttca tggatggcta caagcagaag     1620

aatgcttaca ttggcacaca aggtcctttg gagaatacct atcgtgattt ctggctcatg     1680

gtatgggagc aaaaagtctt ggtgattgtc atgaccaccc gctttgagga aggcggcagg     1740

agaaagtgtg gccagtactg gcctttagaa aaagactctc ggatccgatt tggcttcctc     1800

acagtgacca atctaggcgt ggagaacatg aatcattata agaaaacaac gctagaaatt     1860

cacaacacag aggaacggca gaaacgccag gtgacccact tccagttctt gagctggcca     1920

gactatggtg tcccttcctc agcagcttcc ctcattgact tcttgagagt ggtcagaaac     1980

cagcagagtc tggctgtgag caacatggga gcacgctcca aagggcagtg ccctgagcca     2040

cccattgtgg tccattgcag tgcaggcatt ggcaggacag gtaccttctg ctcactggac     2100

atctgcctgg cacagctgga ggagcttggc acccttaatg tgttccagac ggtgtcacgc     2160

atgaggaccc agagggcctt cagcatccag acccctgagc agtactattt ttgctacaag     2220

gccatcctgg agttcgcaga gaaggagggc atggtatcct ctggccaaaa cctgctggcc     2280

gtggagagtc agtaactctc ctacgaacct cctacctgtt ggccagcctt ccttaaacta     2340

ccctggacac cgctgagcct ataggttgcc atcagttacg ctgaagccat ggatcaactt     2400

ctttcttgtg tctcccagca cacgtgtgca cgcaaggcag cctttccctt tggctagata     2460

aatgtggtga aattgccact agaaagggcc agtagcaatg tgttcttaat tcctagcatc     2520

tgctatcaaa ctgtgcctta ttaaaaccaa attgtggcta ttgatttttg ctagggtccc     2580

cgaggtaagt ggggaaggaa cctccctcct cctttctccc gccattcttt ttctgaggtc     2640

tcctgtctcc cactccttcc ctttcctagg attttatggg gaggtttgat gagcatttgc     2700

ctttctcccc agagagcttg accaagttac atattctaga gatcgtcctg agtgccaagc     2760

acgtttataa gtagggcgtg tattccagtc ctttctgtca ttctgtgtgt gtgtgtgtgt     2820

gcacttatgt gtatgggtcc atatgtacgt gtgtatataa tatatattgt atgtgataat     2880

atgatcgtat tctataaata catatacaca cgatactcct ttccagaagt tcctggggct     2940

ccgtgttgca gttcaggact ccttgcttct tggaccctac tatttatcct ggactagctt     3000

gggttggtga tcatgtctcc tcttgtcagg ctacagagtg gtggaagagg acacacacac     3060

atctcctcca tgttcctgcc acagggcccc ttccttaagt aatgacttat ctccttccag     3120

ttgccacctg ttggagccaa gaatgtatta gtttgtggtg acactgggtt agctcagcat     3180

ggatttccct tatccgatga tttttctaca tttacttggc caatttgggg aacagacctc     3240

cactgtgatt ccatactctc tctttgcttt cactatccca gggatgggag gcggagggta     3300

gagatgaact cactgagcag ccagagccaa atgcaatcgg tacgaatctt agaaggaagg     3360

agggggagcc caggtatgag aaagaaaaaa ccactaagaa aatacctccc tgggaggatg     3420

agctggggcc ctttttcttt tgctggatgg ttcctttatg cagcttggcc ctgtctaccg     3480

agatgcccat ctcttcctgc ctgctagcct gctagaccct caaactgggt gggttctgtg     3540

tcaataaaaa gcttcacccc ctggctgagt gaggtggtcc cctgcaatca ctgtttgtcc     3600

cctacccacc caacctgtcc ctgcctgctc ccagcccact catccttatg tgctagggat     3660

aaatcaagag tcctcagcac tccacattcc caaaaaatcc caggaactcc taaaccttcc     3720

cctgtgacag aagatgaggt tggcagctga tcagacctca ataattttat actgtaataa     3780

gctctttgaa tgtgtatatt attatttttt acaatcattt cattttgtat ttaatatcaa     3840

tggactgagt ctgattcaga aaataattgt aatgttcata ttcaatatct tacagtgata     3900

cagttttgta tttacatata aatataccga catgatcaaa acc                       3943


<210> 757
<211> 7122
<212> DNA
<213> Homo sapiens

<400> 757
cgctcttgcg ggagcgttcc gcatcgcccc gggggcccct acgcgaggat ctccggggcc       60

gttggcagcg cctggcactt ctgagctcgg cggacgagag cctgcaggtt tcctccagtc      120

agggacggcg aagggcggaa agcgcaggag gaggcagtgt taggccttag gccgggtggg      180

ccgggtcagg agagacgcgc ccatctttcg ccatccgggg tgcgcgaggt cctctcggga      240

cccggccggc gacccgtagc tcgggcacgc gcctgtcgca tcccgcagga aggaggggtc      300

cggcctgagg cccggggcgg cgtccgccat ggagatcccc tcggtccagg gccggcgcct      360

gggacctggc gggcggccct gaccgccttc ctccctgcgc gggctgggtc gcggacgtgc      420

ccttcgcggc actcggcctc ctctgcgtct ccgccttccc tgggccgcac tgctgcctgg      480

gcgcggcggc ggcgacggcg ccctgttgaa tgggctgtga gggcccaggt ttaaagcgct      540

ggcgaacgcg gcctccgggg gcgcacggca gctgcagcgg tggcgaccaa acgggtgttg      600

gagttggcgg cggccatgga gggcctggct ggctatgtat acaaggcggc cagcgagggc      660

aaggtgctga ctctggccgc cttgcttctc aaccggtctg aaagcgacat ccgctatctg      720

cttggctatg tcagccagca gggagggcag cgctccacgc ccctcatcat cgcagcccgc      780

aatggacacg caaaggtggt acgcttgctc ttagaacatt accgggtgca gactcagcag      840

actggcaccg tccgcttcga cgggtatgtc attgatggtg ccactgctct ttggtgtgca      900

gctggagcag gacattttga agttgttaaa cttctagtca gccatggagc caacgtgaac      960

cataccacag taactaattc aacccccctg cgggcagcat gctttgatgg cagactggac     1020

attgtgaaat acttggttga aaataatgcc aacatcagca ttgccaacaa atatgacaac     1080

acctgcctaa tgattgcggc atataaggga cacactgatg tggtcagata ccttttagaa     1140

caacgtgctg atcccaatgc caaagcacat tgtggagcca cagcattgca ctttgcagct     1200

gaagctgggc acatagatat tgtgaaagag ctgataaaat ggcgtgctgc tatagtagtg     1260

aatggccatg ggatgacgcc attgaaagta gctgccgaaa gctgtaaagc tgatgtcgta     1320

gaactgttac tctctcatgc tgattgcgac cgaagaagtc ggattgaagc tttggaactc     1380

ttgggtgcct cctttgcaaa tgaccgtgag aactatgaca tcataaagac ataccactat     1440

ctatatttag ccatgttaga gaggttccaa gatggtgata acattctcga aaaagaggtt     1500

cttccaccaa tccatgctta tgggaataga actgaatgta gaaatcctca ggaactggag     1560

tccattcggc aagacagaga tgctcttcat atggaaggcc ttatagttcg ggaacggatt     1620

ttaggtgctg acaatattga tgtttctcat cccatcattt acagaggagc tgtttatgcg     1680

gataatatgg aatttgagca gtgtatcaag ttgtggcttc atgccctgca cctcagacaa     1740

aaaggtaaca ggaacaccca caaggatctt cttcgatttg ctcaagtttt ctcacaaatg     1800

atacatttga atgaaactgt gaaggcccca gacatagaat gtgttttgag atgcagtgtt     1860

ttggaaatag aacaaagtat gaacagagtg aaaaatattt cagatgctga tgtccacaat     1920

gctatggaca attatgaatg taatctctat acctttctgt atttagtgtg catctctacc     1980

aaaacacagt gcagcgaaga agatcagtgc aaaattaaca agcagatcta caacctgatt     2040

caccttgatc ccagaactcg tgaaggtttc accttgctgc atctggctgt caattccaat     2100

actccagttg atgatttcca caccaatgac gtctgcagct ttccaaatgc acttgtcaca     2160

aagctcctgc tggactgtgg tgctgaggtg aatgccgtgg acaatgaggg aaacagtgcc     2220

cttcatatta tcgttcagta caacaggccc atcagtgatt ttttgacctt gcactccatc     2280

atcattagcc tagttgaagc cggagctcac actgacatga cgaataaaca gaataagact     2340

ccgctagaca aaagtacaac tggggtatct gaaatactgc ttaaaactca aatgaagatg     2400

agtctcaagt gcctggctgc ccgagcagtt cgggctaatg acattaacta ccaagaccag     2460

atccccagaa ctcttgaaga gtttgttgga tttcattaag tgactggata tgtaaagtcg     2520

tttaatgtgg tgctaaaaag taaaggactt ttaatcacag acagtagaat tatgtgttca     2580

taaattctgc ttttctttcc actacccttc ctcccatccc atccttcctt agttctgtat     2640

ttgtttttct tgcctcatgg taattgattt cagacagact ttaacaaaac cacattgttt     2700

tggtgtaact ataaggtatt tgcatattgg ttacctattt gtctttcttt tttttaaagg     2760

aacagatata aaatgttttg tttatgtaac aagggacatt tataatttca agttgataat     2820

gttttaaaca gctgcttaca aaagtatttc tgttaagcct atgtcagcat gttatccatg     2880

cagcagtttt gaggatttta tgaagaaaaa gagctaaaaa ggaacattaa gaggaatggg     2940

atatccaggt gttctgcaca tgccaaactg ctgtagatag tttacactct tccattattt     3000

atacggagtg atgcagcaca ttttagcatt caggaggatt tttaaaaaat agctgcagat     3060

taatctggaa aatgtgctaa tttaataata gttacaaatt tataaattta aatccatttg     3120

aaattgttgc attatgctgg gtagtatata caaaatggtt atcatcttaa accaactttt     3180

cagagaatct tgatggactc tgcctttagg cttgaattct tcaaagtcta ttttaatgaa     3240

atttatctaa attgcagcag tctatttgat tcagctcata gacatgtaaa aattatgaat     3300

gctgttttct tatgaaacaa attgtcacag tgtagttata cattctattt ttgtcccctt     3360

ttcccttttt ctcctgtatc ttttaaaatt tggaaactac ttttccagaa ggcattattt     3420

atgcctccct aataaggtat tttacttatg acagatgaaa aggaaccagg atatgtttga     3480

attttttcac tttcttagtc tgtgacaaga agtagaaata tcactagtgt ggtataggaa     3540

cttacatgtt ttttatgatg aaaataattc tcaatgccac ttgaaaggta attgtgtctg     3600

agagctgcaa atttttcaac cacaaaatgt cacttattcc tacaggctat acagaggtct     3660

ttatggtttt tttgttttgt tttaatggca acattgtaac tgtcaaacta aaagggtatt     3720

ctgtgattat cttttaagca ttacagaaat tcaagtgaaa gttatatgct tatttctatt     3780

gatgttaaaa atgataatga aagcaaaatt agctgtatct gtaattttct ctctagtgcc     3840

aaatgaatgc cttagctact catagtgcat ggtactgtaa gtgaagacct gtagcttttt     3900

ttttttcttt aatgaaaagc attataatga tgtagcagca tcagatataa acttaaaaaa     3960

aaaggtttca attaacattt tatatatgga taatgctttg taaagtgtaa gagaaaggtt     4020

gcagttggat cagtataaaa caatgaccaa gccaaaatca gcaccctagg gccttaaata     4080

aaatagagat accccacaaa atgaaatatt ttgaaggatg ggaggggaca gaagggggga     4140

ctatccccca aggatgcaag atacttttta cagttgctat cattatactt tgtcttcttg     4200

cttcagttag gaaggttttg atggtaaatt ctgtcatggt aatagatacc tattttccta     4260

acctgagatt ttacaaggaa ggtttttagg ttggcttaaa tggaggtatt tatttgagtg     4320

agccctaatt tgaaaattac cagacttgat cctcctggta tgaatcaagg aaatactgta     4380

ccttgctctt agcaactctc agtggcctga aagagaaaat gcacttcttc aaggtgagtg     4440

aatcatgctt tttccacagt tcagatcaga ccctttattt ttcaaactac aaggcctgct     4500

tattggacag tctaaggaat agctttgata cttggtattc agttggttcc attattaatg     4560

tatattattt ttatttaaac atcaaaactt aaaatatcag ataatgttgc atgttttaaa     4620

aacacatttc atccctttgg ctacccagga ccagcactat ttaagacact gcttatttat     4680

aaaatgagaa taatgattat atgtacatat tcagacatca aaatttaatg acattctatt     4740

ttgagaaggg aagacaatgc tgaagaaagt aaaactgttg attgaaatgc tgacagggtg     4800

gagaacgaat ttgaagacag tggaataaac tatgaactat gctaatggta attagatttt     4860

ttgtttgttt agtatagtgg taaattgtgt agtatcttgc tgagaatcta attctatctt     4920

gtaaaatcaa tccaaatgtg tattgtgaaa cacctgtata aaatcatttt tgaaataagt     4980

gatctacatg cctgtttttt taaaatgttt ttggtagaat tgtttgaaaa tatgtttagc     5040

cagacccttc cccaacttaa ttttttttta aaaaaggaaa ataggtaaga aaatgatagt     5100

tctatatctc agccctctgt gaactctagg ctgtctccat tttgcagcca ctttggtcat     5160

ttgatgttta ctattggtat acttatgctt tgaattgtaa atcttcattg atggtattac     5220

agattcaacc aaaacttctc tgtcctgttc agtaattgtt atataaatct ggatgagcta     5280

gggaggccca ggtggatgtt ttcattcgca aatcatgaga aacttaagtg ggttttatgc     5340

acttgataga gttggcaaaa ttgaactatg aagttaacta tttaactcaa ggaatgggcg     5400

gcaaacccat cccctcgatt gataaagaag gggaacattt ttacattaga actgacactg     5460

aaaacatagc tttttcagtc caccctggtt gctctagtag cccacagccc aatcacgtta     5520

aggttctttg ctgtgggaat tttaaataaa ccaaacccca aagcagacca tctgtaagct     5580

ttggtctgct tgtttctgag aagggtttta tttcattata ctaatagtgg actaataatt     5640

ggtaattgtg agaacttagg tatgataaca ttgtttgaag taaaatatga tttgggggca     5700

gcagctttct aaataccaac tctgtttgac aaatgttttg aaaattaaaa tttcaagtga     5760

gcaacaccct gttaagagtt ttcactatag ttgaggcagc tactttatga ataagaccac     5820

tttgggttat ttaagcagaa gcgtttcttt tttttttttg gaatggggtg ggatgaggag     5880

tgagttgcca gacctttgat tagtttgctg gtttagaaac agccagtggc tgaattagtg     5940

agtaaatgaa tgaaagtata aaggacttgt tttttatgat agattttctg taagaatctt     6000

aaatgttcct tttcaaatta gatgtgttga tgcacacatg actattctgt ttttctcact     6060

gactatataa cattaaaaag gggttaaaga aaacaaaact ctgccttttg tgctatgaaa     6120

tatttttagt ccagaggttt taagctgtgt gtccattcct actctgaaaa tgcatagctt     6180

tgttctggat gtcatctctt gaaagtagaa aactcctatg tgtttatcac attgcagggc     6240

tttcttatgt atttctggca gacttgccca aatctttaga tgggctgggt tatacagcat     6300

gccctccccc aaataaggga tctgaaataa atactacact attgatagtg gagatatatt     6360

aatttttaaa actgtaaagt aaatgtggtc tctaggtttg tggtgtgtac ctttgtgtta     6420

atgtgtaggg aagagacagt gacttgatgg ttatggggag tgtatcttga tgtgtgtata     6480

ggggtaagta ttgctaaatt atttacagct tttattcagg gtgagtcatg tgatgaatgg     6540

cctaatcaga aaagtgaagg agcgaagatg caagcttgcc aaatgatgaa atgaacaaga     6600

ttttgtatct attttttatc aggtgttgta aaatttgtgc atggcttttt gttgttgttg     6660

cttagtaact ggtagaggag aaaagatgag gaaagaaact cagctttcct cacagtcttt     6720

tcaaaggtac acagttgggg agtaaaatct gactggccta atcgatggaa aagaccctgt     6780

ccttttcacc ccatcctgca atcctccgtg cagaggaact acactgttgt attctagtaa     6840

ttcactgtga tttataacaa accggtgatg tcattctatt gtgcactttt gtcaaaccat     6900

ttatgtgact ttaataaaca tagtaaactt gctgactgca ccagaggtcc attagtgatt     6960

tatatattgc atgacatttt ctatttgagt ttgacatgta gagtcatttt tagtttcatg     7020

gcaattgaca gtcctaataa ctcagctaat ttgaaactaa caatcttgct gtgtaaaagg     7080

aaaaaatggt gtttgtgttc agtaaatgtt tgaaaaaaac ta                        7122


<210> 758
<211> 832
<212> DNA
<213> Homo sapiens

<400> 758
gcaaggctcg cagccacctc tcgggagtgc agggccagat cctgtgccag cggccttaca       60

cggccacagt cggattcgct gccgcagcag ccgccacccc caggagccgc cgggaccctc      120

gcgtcgtcgc cgccgcggcc cagatcccca caccatgccg tcggagaaga ccttcaagca      180

gcggcgcacc ttcgaacaaa gagtagaaga tgtccgactt attcgagagc agcatccaac      240

caaaatcccg gtgataatag aacgatacaa gggtgagaag cagcttcctg ttctggataa      300

aacaaagttc cttgtacctg accatgtcaa catgagtgag ctcatcaaga taattagaag      360

gcgcttacag ctcaatgcta atcaggcctt cttcctgttg gtgaacggac acagcatggt      420

cagcgtctcc acaccaatct cagaggtgta tgagagtgag aaagatgaag atggattcct      480

gtacatggtc tgtgcctccc aggagacgtt cgggatgaaa ttgtcagtgt aaaaccagaa      540

aaaatgcatc tcttctagaa ttttttaaac ccttaccaag gaaaaaaaaa gggatgttac      600

caactgagat cgatcagttc atctaatcac agatcatcaa acagtagtgt tcccacctag      660

gagtgttagg aagttgtgtt tgtgtttcaa gcagaaaaac tgagctccaa gtgagcacat      720

tcagctttgg aaactatatt atttaatgta ggctagcttg ttttcaaatt ttaaaagttt      780

aaaaataaaa tactttgcat tctaaaaaaa aaaaaaaatt gccttacaca at              832


<210> 759
<211> 7295
<212> DNA
<213> Homo sapiens

<400> 759
gagcccatta gccgcacaaa ttcgcagcag gcggctgggg cggcggctgg ggcagcggct       60

gcagcagcgg cggacgctct gcattaccca gtcttgcgtc ctcggcaggc gcccgaagct      120

gagtgcgcat cctctaccgc acccaagctt cgtctgtctc gtcaagctct tcatgctgcc      180

caactaaaag gaaaacatgg gcacagggga ttttatctgc atttccatga ctggaggggc      240

gccctggggg ttcagattgc aaggtggcaa ggagcagaag cagcccttac aagttgcaaa      300

gattcgaaat cagagcaaag cctctgggtc tgggctctgt gagggagatg aagtggtttc      360

catcaatggc aacccttgtg cagatctcac ctaccctgaa gtcatcaagc tcatggaaag      420

cataacagac tctctccaaa tgctcatcaa aagaccatcc agtggaataa gtgaggcttt      480

gatatctgaa aatgaaaaca aaaacctcga gcatctcaca catgggggtt atgtggaaag      540

taccaccctg cagattcgac cggccacaaa gacccagtgc acagaattct tcctcgcccc      600

tgtcaagact gaagttcccc tagctgagaa ccaaagaagt ggtcccgact gtgcaggcag      660

cttgaaagaa gaaacaggcc cgagctacca aagggctccc caaatgcctg actcccaaag      720

aggacgcgtg gcagaagagc tgatcttaag ggagaaggta gaagcggtac agcctgggcc      780

tgtggttgag ctgcaactgt ccctttcaca ggagagacat aagggcgcta gtggcccttt      840

agtggctctc ccgggagctg aaaaatctaa gtctcctgac ccagacccta acttgtcaca      900

tgacaggatt gtccacataa attcgatccc tactaatgag aaagcagacc ctttcctgag      960

gtccagcaag ataatccaga tctccagtgg cagagagttg agagtgatcc aggaaagtga     1020

agcaggagat gcgggactgc cccgggtgga agtgatcctc gactgctctg acaggcagaa     1080

gacagaaggg tgcaggcttc aggcaggaaa ggagtgtgtg gattctccag tggaaggagg     1140

gcagtcagaa gcacctcctt ctctggtatc ctttgccgtc tcatcagaag gcacagagca     1200

gggagaagat ccacgctcgg aaaaagatca cagcagacct cacaagcacc gagcgcggca     1260

tgcacggctc aggaggagtg aaagcctgtc agaaaaacaa gtgaaggaag caaaatctaa     1320

atgcaaaagc attgcccttc ttctaacgga tgctcccaac cccaactcca agggggtgtt     1380

gatgtttaag aagcgacgtc ggagggccag gaaatacacc ctagttagct acggtactgg     1440

cgagcttgag cgagaggcgg acgaggagga agaaggtgac aaggaggata catgtgaagt     1500

agcatttctt ggtgcaagcg aatcagaggt ggatgaagag ttattgtctg acgttgacga     1560

caacacacaa gttgtgaact ttgactggga ttctggactg gtggacattg aaaagaaact     1620

gaacagaggg gacaagatgg agatgttacc agacaccaca ggcaagggag ccctcatgtt     1680

tgccaagagg agggagagaa tggatcagat cacagcccaa aaagaagagg acaaggtagg     1740

tggaacgcca agcagagaac aagatgctgc ccagaccgat ggcctgagaa ccacgacttc     1800

ttaccaaaga aaggaggaag agtcggtaag aacgcagagc tctgtgagca aaagctacat     1860

cgaggtgagt catggtcttg gccatgttcc ccaacagaat ggcttcagtg ggacatctga     1920

gacagcaaac atccagagga tggtccccat gaatagaacg gccaaaccct tcccagggtc     1980

tgtgaatcag ccagctaccc ccttctcgcc aacccgaaac atgacgagtc ccattgctga     2040

ctttcctgca cctccacctt actctgcagt cactcctccc cctgacgcct tctccagagg     2100

ggtttcaagt ccgattgctg gcccagcaca gccccctcca tggccccagc ctgccccgtg     2160

gtcccagcca gccttttacg attcgtctga gcgaatagct tcccgagatg agaggatctc     2220

agtgccagca aaaagaacag gaatattgca ggaggccaaa aggagaagca cgacaaaacc     2280

catgtttact tttaaagagc ccaaagtaag cccaaatcct gaactcttgt cactccttca     2340

aaattcagaa ggcaaacggg gcactggagc tggaggtgat tccggaccgg aagaagacta     2400

cctcagcttg ggggcagagg cttgtaattt catgcaaagc tcctctgcca aacaaaagac     2460

ccctcctcct gttgctccaa aacctgcagt caagtcctca tcctcccaac cagtaactcc     2520

agtttcccca gtctggtctc caggagtggc tcccacccaa cctcctgcct tccccacatc     2580

caacccatca aagggcaccg ttgtctcctc catcaaaata gcccagcctt cttaccctcc     2640

tgcccggcct gcaagtactt tgaacgtggc tggtcccttc aaaggaccac aagcagcagt     2700

agccagtcag aattacacac ccaaaccaac agtttccaca ccaacagtca atgctgttca     2760

gcctggtgca gtgggaccat ccaatgagct tccaggaatg agtgggagag gagctcagct     2820

ctttgctaaa aggcagtcga gaatggagaa gtatgtggtc gattcagaca cggtgcaggc     2880

ccacgctgct cgagctcagt ctcccactcc atctctcccg gccagttgga agtactcctc     2940

caatgtccga gcacctcctc ctgtggccta taatcctatc cactcgccgt cttacccact     3000

ggctgctctc aagtctcagc catcagctgc acagccctcc aaaatgggca agaaaaaggg     3060

aaagaaaccc ctcaatgcat tagatgtcat gaagcaccaa ccgtatcagc tcaatgcatc     3120

cttgtttact ttccaacctc cagatgcaaa ggatggcctc ccccagaagt catcagtcaa     3180

ggtcaattca gccctggcca tgaagcaagc tcttcctccc cggccagtga atgctgcctc     3240

acctacgaat gtgcaggctt cgtcagtgta ctcggtacca gcctatacct ctcctccttc     3300

cttctttgca gaggcctcct caccagtcag tgcatcccca gtgcctgtgg gcattcccac     3360

ctcgccaaag caagaatcag cctcatcatc ttattttgtg gcaccaaggc caaagttctc     3420

agccaagaaa agtggtgtca caattcagga gagtgggcgc tccctttctc ttcctggaag     3480

atcagtccca ccccccattt ctacatctcc ttgggtatac cagcctactt atagttactc     3540

tagtaaacca accgatggac tagagaaagc aaacaagaga ccaactcctt gggaagcagc     3600

agcaaagtct cctctcggtc tagtggatga tgctttccaa cccagaaaca tccaggaatc     3660

cattgtggca aatgtggttt cagcagctcg gaggaaggtg cttccagggc ctccagagga     3720

ttggaatgaa agactgtcct atattcctca aacccagaag gcctatatgg gctcatgtgg     3780

aaggcaagag tataatgtca cagccaataa taatatgtcc accacctccc aatatggttc     3840

acagttgcca tatgcatatt ataggcaggc ttcaagaaat gattctgcaa tcatgtccat     3900

ggaaaccagg tctgattact gtcttccagt agctgattac aactacaacc cacacccaag     3960

gggatggaga cgccaaacat gaaagttaga agaacggatc atgtgccaac tgtagttttt     4020

taaaaaaaac gctcctttgt agggttttaa acttttctaa tagatttaga ttcacttttg     4080

gtcttggctt gttctcataa gtcatttatc taagtttgtg tttctgtgtg tgtgtgtgtg     4140

tgtgtatgta tgtgaatata cacacacaca cacacacagg tgagtgtgaa tacttccttg     4200

ttggctgatc catagagcat tacttggaag aaaatttcac tatttgcatt gatgtgctgg     4260

catttatatg taattcataa ttttgattcc attaataggt agtctatgca acaaactcta     4320

ctcaattaaa gtaaaactaa gtatttcttc attgtacctt agtccaggaa gaaattaatg     4380

gaatatggtg tgctaattat cactacctat aacatgagga atataacatt gcagaaattt     4440

ctcatagggg catgccagtg agcaattact ttataaaaat attttccttg gtgttaagta     4500

tttctctgca actttttttt tttttttttt ttttttttga gatggagtct tgctctgtcc     4560

cacccagtct ggagtgcaat ggtgcgatct tggctcactg caacctgcgc ctcctgggtt     4620

caagcaattc tcctgcctca gcctcctgag tagctgggat tacaggcatg aaccaccaca     4680

cctggataat ttttgtattt ttagtagaca caaagtttca ccatgttggt cagactggtc     4740

ttgaactcct gacctcgtga tctgcccgcc tcagcctccc aaagtgctgg gattacaggc     4800

gtgagccacc acacctggcc tttctgcaac atttttttaa aaaaatctaa taaatcttag     4860

atttttaaaa aagaattaaa atgtgggagt tctcagaaag aaataaacac atgagaataa     4920

gattattaca cattttggaa ggacttttga ggaatgatgt gatgtgtaga gaatagaaag     4980

atttagatat atgcctgtga caggaataga ttctgggttc aggggtcccc atctgtcaaa     5040

tgagaagatt ggattatcta atcttttaga tccttaacaa ctctgatatt ctgagattct     5100

ctcatttgta gaatgcccgc tgatgcattg tttatttttt ttgctcataa tataaatatc     5160

agattatgtt taggagtgga ttaggtaatt agtgtcacta catgtatcat taaaggtcct     5220

aaaaggaatt gttaggcggc aggctttgtg ttacgtgtta catggagtga gggtagatgt     5280

gaagatttaa aacgattgat ggatttaagg aagtggtaca taaatatgtc tgttattatg     5340

caatcgtagg tcatgataat ttattcagtt atagaaaaca tgccacagaa gcctatgtaa     5400

caagtggtgc ttctttagaa agttgtcatt agaatgttct gaggaagtta agcagctgct     5460

tcatcaatcc catgacacat gccttgttag catgcccatc aaataatcag atcaaacacc     5520

tgctccttat tgccataccc acgaactgtt aaatataaaa aaattcaaag tatttgacat     5580

cttaagcaaa tatccagaat atttttaagt aaaaaaccat cttaagtatt caaaatttcc     5640

ttggtttttt aaaggtgata attttgcttt gtgttacttt tttgctcttg aatgtatcgt     5700

tatgatggtc tcttataatc atggtatctt tcacagaata aaaattaaaa ataatgccag     5760

ggtgcaagtg accaaggcct tatcttgaaa gttaaaaaaa aaaagtaaag aaatcacagt     5820

aagttctatt agtgatgata gaaccagata taaaattgtt cagtgatgga gaaaagaaac     5880

gataaatact ttccaaggtt atattgttaa attatcttaa attatcaagg tgtaagatgt     5940

aatgatccca agagttttta tagaatccta aaaaataacg cctgatgtat agattagtta     6000

gcaaattctc agaaatcccc cacataaaag ccttactttg ttcaaaattt attatagtgg     6060

tttaatcatt ttagatttga atgttttaag ataggagaga cttagcagaa aatacttggc     6120

ttgccagggc cacgttctac ttcattgctt tcttttataa gtgcaaggag ttatttccat     6180

cagttgacat agatattatt cactaaaatt ttcagcagac tcaaaataga gaggagactt     6240

taaacttaca tgttagcata aaacagactt ctctctcatt gcatgcacta gatcaatatt     6300

atcatctgta ttaagctatc tgaatttatt cgagacatta agaaaaagac agtacatggt     6360

gggaaagctg cacatttctc acaaggaaaa aaacattcta tatttgtagc agaaatcagt     6420

ggtttgaaaa gtcatacttt gcagatatga acctgaaaat caaagtgcca ttgttaaatc     6480

atcctaaagt gtactgtggg tattctccag catacttgaa aatgaataaa gttagattgc     6540

tcacattgaa gctaatggtt gagacaagac acctgccaga gtgaagtttg attcctatgg     6600

gtgagaagat gtagatgact attgttctca ctaaagttct aaaataatag caagtgtaga     6660

gaagagccgt tgctttgaaa atacatacca catttgttat aaagcatttg tttgttagta     6720

tcaatcacat aggtagaaag agtttgagtt ttactgtgga ttaaaaagcc ttccctaaaa     6780

agagagcatg ccagtcatag agacactaat ttggcacttt tcctccttct taggtttaaa     6840

tgttatacca atgcatgtgt ttgaaatatc cattaagatg atttaaaatt tgtcttgtat     6900

tttgagtttc ttaaatgcgt ggattcttgt tcatttatct ctgaatatgt ctcttttata     6960

ttttggcaca attatacaca ttggaaaggg ccaacctatt agggctcaag tatgtatatg     7020

caaaaaaaaa aagttatatc aaacaggcac agttattaca actagagaga aattccagaa     7080

atatttgttt ttttaagaga aagtaaattt tcacattaga tttctattca aagtactaat     7140

atctacatgg tccacacttt tctattttaa aaaattgtgt tctcttgtta aatagattaa     7200

catttccact tctgtttatc acaaaagact gtatttgaaa tatgcatacg gaaaattgaa     7260

attatattag taataaatgt aacttgaaaa atcaa                                7295


<210> 760
<211> 1664
<212> DNA
<213> Homo sapiens

<400> 760
agagtgctga aggtcctgcc aacggctctc ttggcgtctc aacgttcgga tcagcagctt       60

ttttccattc tctctctcca cttcttcagt gagcagccat gagttggact gtgcctgttg      120

tgcgggccag ccagagagtg agctcggtgg gagcgaattt cctatgcctg gggatggccc      180

tgtgtccgcg tcaagcaacg cgcatcccgc tcaacggcac ctggctcttc acccccgtga      240

gcaagatggc gactgtgaag agtgagctta ttgagcgttt cacttccgag aagcccgttc      300

atcacagtaa ggtctccatc ataggaactg gatcggtggg catggcctgc gctatcagca      360

tcttattaaa aggcttgagt gatgaacttg cccttgtgga tcttgatgaa gacaaactga      420

agggtgagac gatggatctt caacatggca gccctttcac gaaaatgcca aatattgttt      480

gtagcaaaga ttactttgtc acagcaaact ccaacctagt gattatcaca gcaggtgcac      540

gccaagaaaa gggagaaacg cgccttaatt tagtccagcg aaatgtggcc atcttcaagt      600

taatgatttc cagtattgtc cagtacagcc cccactgcaa actgattatt gtttccaatc      660

cagtggatat cttaacttat gtagcttgga agttgagtgc atttcccaaa aaccgtatta      720

ttggaagcgg ctgtaatctg gatactgctc gttttcgttt cttgattgga caaaagcttg      780

gtatccattc tgaaagctgc catggatgga tcctcggaga gcatggagac tcaagtgttc      840

ctgtgtggag tggagtgaac atagctggtg tccctttgaa ggatctgaac tctgatatag      900

gaactgataa agatcctgag caatggaaaa atgtccacaa agaagtgact gcaactgcct      960

atgagattat taaaatgaaa ggttatactt cttgggccat tggcctatct gtggccgatt     1020

taacagaaag tattttgaag aatcttagga gaatacatcc agtttccacc ataattaagg     1080

gcctctatgg aatagatgaa gaagtattcc tcagtattcc ttgtatcctg ggagagaacg     1140

gtattaccaa ccttataaag ataaagctga cccctgaaga agaggcccat ctgaaaaaaa     1200

gtgcaaaaac actctgggaa attcagaata agcttaagct ttaaagttgc ctaaaactac     1260

cattccgaaa ttattgaaga gatcatagat acaggattat ataacgaaat tttgaataaa     1320

cttgaattcc taaaagatgg aaacaggaaa gtaggtagag tgattttcct atttatttag     1380

tcctccagct cttttattga gcatccacgt gctggacgat acttatttac aattcctaag     1440

tatttttggt acctctgatg tagcagcact tgccatgtta tatatatgta gttggcattt     1500

ggttcccaaa aagtaggatg taggtattta ttgtgttcta gaaattccga ctcttttcat     1560

tagatatatg ctatttcttt cattcttgct ggtttatacc tatgttcatt tatatgctgt     1620

aaaaaagtag tagcttcttc tacaatgtaa aaataaatgt acat                      1664


<210> 761
<211> 1323
<212> DNA
<213> Homo sapiens

<400> 761
cgcaacccgg gcggcgagat ggcgctttgg tgtaagcgag gaggacagta caggacatga       60

gtcctggtga gggacccgag gagcaggaca gagaagacgg cccctgaatc ccatttggcc      120

ccttgctggc tggaggtgtg aaaaccagcg gtggaggcag ccttcggggc ctgcatttga      180

gaataagggt gtcactagtt ccaggcgtct gctgaaagat ttggaacaga agatgatggc      240

cactccgaac cagaccgcct gtaatgcaga gtcaccagtg gccctggagg aggccaagac      300

ctctggtgcc ccggggagcc cccaaacacc ccctgagcgt catgactctg gtggttccct      360

gcccctgaca ccgcggatgg agagccactc agaggatgaa gatcttgctg gggctgtcgg      420

tggcctgggc tggaacagta ggagtccccg gacccagagc ccagggggct gctcagcgga      480

ggctgtgctg gcccggaaga aacaccgtcg gcggccatcg aagcgcaaaa ggcactggcg      540

accctacctg gagctgagct gggctgagaa acaacagcgg gatgagaggc agagccagag      600

ggcctcccgg gtccgcgaag agatgttcgc caaaggccag cccgtggccc cctacaacac      660

cacccagttc ctgatgaatg acagggaccc ggaggagccc aacttggatg tgccccatgg      720

gatctcccac ccaggttcca gtggggagag tgaggccggg gacagtgatg ggcggggccg      780

agcgcacggt gagttccagc ggaaggactt ctctgagact tacgaacgct tccacaccga      840

gagcctgcag ggccgcagca agcaggagct ggtgcgagac tacctggagc tggagaagcg      900

gctgtcgcag gcggaggagg agactaggag gctgcagcag ctgcaggcgt gcaccggcca      960

gcagtcctgc cgccaggtgg aggagctggc tgccgaggtc cagaggctcc ggaccgaaaa     1020

ccagcggctt cgtcaggaga accagatgtg gaaccgagag ggctgccgct gtgatgagga     1080

gccgggtacc taggggtgcc tcccagcctg gtggacccaa ggagaaggtc ccatttcgtg     1140

cacactcagg ccagctgggt ctcaaggagg caggtggcag atgaaaacca ccgtcaacac     1200

cctgtgcgcc ctgagaacag ctaaatcggt tcagactccc acctcaccgt ttccatagtt     1260

ggctcttttg tgtcatctta ccctttacag agaaattaaa tggccttggt gggaccaaat     1320

ggg                                                                   1323


<210> 762
<211> 1444
<212> DNA
<213> Homo sapiens

<400> 762
aaccattgtg atggtctaga taagtgtaca tgcttaggcc ttctgaagca gcatttgaag       60

ctgcagtcct gaaaaccatg caggccggaa gagtagataa agaaatattt atttgagatg      120

gcacatgttt cttcagaaac tcaagatgtt tcccccaaag atgaattaac tgcttcagaa      180

gcctccacta ggtctccatt gtgtgaacac accttccctg gggactcaga cttacggtca      240

atgattgaag aacatgcttt tcaggttttg tcacaaggat ccttgttaga aagtccaagt      300

tacacagttt gtgtctctga gccagataaa gatgatgatt ttctttctct gaactttccc      360

aggaaacttt ggaaaatagt ggaaagtgac caattcaagt ctatttcatg ggatgagaat      420

ggaacttgca tagtgattaa tgaagaactc ttcaagaaag aaattttgga aacaaaggct      480

ccttacagaa tatttcaaac tgatgctatc aaaagttttg ttcgacagct caacctttat      540

ggatttagta aaattcaaca gaattttcaa agatctgcct ttctagccac ctttctgtca      600

gaagagaaag aatcgtctgt cttaagcaag ttaaagttct attataatcc aaatttcaag      660

cgtggctatc cccaactttt agtaagagtg aagagaagaa ttggtgttaa aaatgcttca      720

cctatatcta ctttattcaa cgaagatttc aacaagaagc attttagagc aggggctaac      780

atggagaatc ataattctgc cttagctgct gaagctagtg aagaaagttt attttcagcc      840

tctaaaaatt taaatatgcc tctaacaagg gaatcttctg tcagacagat aattgcaaat      900

tcatctgtcc ccattagaag tggtttccct cctccttcac cttcaacctc agttggacca      960

tcagaacaaa ttgcaacaga tcaacatgct attttaaatc agttgaccac tattcatatg     1020

cactctcata gtacctacat gcaagcaagg ggccacattg tgaattttat tacaaccaca     1080

acttctcaat accacatcat atctccctta caaaatggtt attttgggct gacagtggaa     1140

ccatctgctg ttcccacacg atatcctctg gtatcagtca atgaggctcc atatcgtaac     1200

atgctaccag caggcaaccc gtggttgcaa atgcctacga tcgctgatag atcagctgcc     1260

cctcattcca ggctagctct tcaaccatca ccactggaca aatatcaccc taattacaac     1320

tgatctgcca ttaaaagagg accagattat gaatgacaac agagactaac atttacattg     1380

acaaaaaacc ctaaaaattt ctgcaattat cttattgaac aataaaattg catgtttact     1440

tcta                                                                  1444


<210> 763
<211> 2625
<212> DNA
<213> Homo sapiens

<400> 763
gcgacgccga gtttcactct ggctgccttc tcctgagagt cggagccaca gccagagccc       60

tgcccaggcc gagccggagc tgcagcccga gcgcggtggt gccctcagcc ccgtcctctt      120

gtcctcctca gcctcggtgc cttggaattt gtgtcgctga gtcagcaagc ctttcagatt      180

tgcccggttt ttgttgtttg tggtttgtat caagatggga actcaaacaa gtcattcctc      240

ctaaggagct ggtgtcttca tccagaaggg acagtttgtg ccagctctcc agagagaaaa      300

ggatctggta ctgttctgga gtggcctgta gcagacactg aaccaccagc cagctgcatt      360

tgttgtcctg gaagtcattg ccaactctgc cagtcacact ggggtcccca gagaagtcaa      420

gatctgccgg aggcgctggg caatgacccc gggactccag gccagagggg tctgaagctg      480

tttgggaaag cagcgggact ccttgggaag atggccatgg ccccaagccc ttccctggtg      540

caggtgtaca ccagccccgc ggctgtggcc gtgtgggaat ggcaggacgg gctgggcacc      600

tggcacccct acagtgccac cgtctgcagc ttcatcgagc agcagtttgt ccagcagaag      660

ggccaacgtt ttgggcttgg gagcctggcc cacagcatcc ccttgggcca ggcagacccc      720

tcgctggccc cttacattat tgacctcccc agctggaccc agttccgcca ggacaccggc      780

accatgcggg ctgtgcggag acacctgttc ccccagcact cagcccctgg ccgaggtgtc      840

gtctgggagt ggctgagcga cgatggctcc tggactgcct atgaagccag cgtctgtgac      900

tatctggagc agcaggtggc caggggcaac cagctcgtgg acttggcccc cctggggtac      960

aactacactg tcaactacac cacccacacg cagaccaaca agacttccag cttctgccgc     1020

agcgtgcggc gccaagcagg gccgccttac ccggtgacca ccatcatcgc tccgccgggc     1080

cacacaggcg tcgcctgctc ttgccaccag tgcctcagtg gcagcagaac tggccccgtg     1140

tcaggccgct accgccactc catgaccaac ctccctgcat accccgtccc ccagcacccc     1200

ccacacagga ccgcttctgt gtttgggacc caccaggcct ttgcaccgta caacaaaccc     1260

tcactctccg gggcccggtc tgcgcccagg ctgaacacca ccaacgcctg gggcgcagct     1320

cctccttccc tggggagcca gcccctctac cgctccagcc tctcccacct gggaccgcag     1380

cacctgcccc caggatcctc cacctccggt gcagtcagtg cctccctccc cagcggtccc     1440

tcaagcagcc cagggagcgt ccctgccact gtgcccatgc agatgccaaa gcccagcaga     1500

gtccagcagg cgctcgcagg agcgaccccg aagccagagc cagagccaga gcaggtcata     1560

aaaaactaca cggaagagct gaaagtgccc ccagatgagg actgcatcat ctgcatggag     1620

aagctgtcca cagcgtctgg atacagcgat gtgactgaca gcaaggcaat cgggtcccta     1680

gctgtgggcc acctcaccaa gtgcagccat gccttccacc tgctgtgcct cctggccatg     1740

tactgcaacg gcaataagga tggaagtctg cagtgtccct cctgcaaaac catctatgga     1800

gagaagacgg ggacccagcc ccagggaaag atggaggtat tacggttcca gatgtcgctc     1860

cccggccacg aggactgcgg gaccatcctc atagtttaca gcattcccca tggtatccag     1920

ggccctgagc accccaatcc cggaaagccg ttcactgcca gagggtttcc ccgccagtgc     1980

taccttccag acaacgccca gggccgcaag gtcctagagc tcctgaaggt ggcctggaag     2040

aggcggctca tcttcacagt gggcacgtcc agcaccacgg gtgagacgga caccgtggta     2100

tggaacgaga tccaccacaa gacagagatg gaccgcaaca ttacgggcca cggctatccc     2160

gaccccaact acctgcagaa cgtgctggct gagctggctg cccagggggt gaccgaggac     2220

tgcctggagc agcagtgacc tcgcacccca gcacgcccgc ctctggtggc caccccgctg     2280

ccccatggct ggctgggtgg ccaggcagga agtgcccagc ccgagaggct gggaggtttg     2340

ttgagggtgt ggggtgtgcc ccacctgaag ccggggctcc ccctgcctgc ctctctctcc     2400

tcctcccctc tgggaattgg gcagccctgg gcagttgtac tcatgggggc ttaggatgca     2460

gctacctcag tgcgcagggc ccgtctgtcc tctgggggct gcttcgggcc cgcggtgctc     2520

ggggcctggt gtggggcgag tagagacttc cccagcctgg acgggcgtgg gttctgggtc     2580

agcttctttt acctcaattt tgtttgcaat aaatgctcta tagcc                     2625


<210> 764
<211> 2615
<212> DNA
<213> Homo sapiens

<400> 764
gactttttgc tccaagtgcc agaattgatt gtggttagga catcttacgc tgagaaataa       60

ataaaatgga acataatggg tctgcttcaa atgctgataa aatccaccag aatcgcctgt      120

cgagtgttac agaagatgaa gaccaagacg ctgctcttac cattgtgact gtgctggaca      180

aagtagcctc catcgtggac agtgtgcagg caagccagaa gagaatagaa gagagacaca      240

gggaaatgga aaatgccata aaatccgtcc agattgacct gttgaagctt tcacagtcgc      300

atagcaatac agggcatatc attaacaaat tgtttgagaa aacccgaaaa gttagtgctc      360

acattaaaga tgtgaaagcc cgggtggaga agcaacaaat tcatgttaaa aaagttgaag      420

tcaagcaaga ggaaataatg aagaaaaaca aattccgcgt ggtaatattc caggagaagt      480

ttcggtgtcc gacatccctg tctgttgtta aagacagaaa cctaactgag aaccaagaag      540

aggatgatga tgatatcttt gatcccccag tagatctgtc ttcggatgaa gaatattatg      600

ttgaagaaag cagatctgcc aggcttagga agtcaggcaa ggagcacatt gataatatca      660

agaaggcatt ttccaaagaa aacatgcaga agacacggca gaatcttgac aagaaagtga      720

acagaattag aactagaata gtgaccccgg agaggagaga gaggctaagg cagtcaggag      780

agaggctgag acagtcaggg gagaggctga gacagtcagg ggagaggttt aagaaatcta      840

tttctaatgc agctccctca aaggaagctt ttaagatgcg cagcctcagg aaaggtaagg      900

accgaacagt ggctgaaggt gaggaatgtg ccagggagat gggtgtggac atcattgcca      960

ggagcgagtc tctgggcccc atcagtgagc tctactctga tgagctcagt gaaccagaac     1020

acgaggcagc caggccggtg tatcctcccc atgaaggaag ggaaatcccc acccccgagc     1080

ctttaaaagt tacttttaaa tctcaggtga aagtagagga tgatgaatct cttttgttag     1140

atttaaagca ctcatcgtaa agaggaatta agtatatcct aaatatgaat ctcctaatca     1200

tgcagtttta gtttgaatag tgtagtcgtc tacatttctg tgccatgtag gaaaacataa     1260

atgtattttt tttcttatat ttaaaatctt gaagataata taaatattat tatcactctt     1320

tctcatggca gctgtggatt ttttagttcc tttctcttgt ccaccagaaa aatagtttcc     1380

taggttgggc cagttacgtg tttggtaagg gcaactttgc ggccgtcatt tgcaggagaa     1440

ctctaaatat tggttaggat taatattgtg gccagcctca aaggggaata actcatgtgt     1500

gggttatatc gtccagatgt tcagatcaac agatttgtta gtaaattagc agtcacaccc     1560

cttttttgat gctttcacat taaaaaattg aagttttgga cttgagcatt tggctctagt     1620

atcatagctt tacttataag aaaaccctgg gcaagtcatc tgcttattct catcagtaaa     1680

aatggagagg gttggcctct gctgcctgcc tcagaggact gttgtgatga tcaaaggaaa     1740

tggtacacat tctgggggaa caagaagcac acccagagaa aacaagcctc atcagttcct     1800

ccaaaacaga atggaaagag ttacaccttc tgaaaaagcc ctcagcacca atcaataagg     1860

tcctaggttg gagagaaact aaagctggtc ttcagaagcc ttttcacaga atcaagagtg     1920

aaaaataagt aaatgtttgg gtgaccactt tttcatcaga ctaactatat cttgggtttt     1980

agttgggtct caaaatgttc cccagccaga ccctttctaa tttccttttg attaagatct     2040

ttggtggact atagcactaa atttgtttaa gcagtatgag gcataaaatt gtgactatgt     2100

ttctaaagtc ggccctgatg cattgggttt ggaaatgacc acaaatattc ctgttttcct     2160

gagtgtaccc ttcagggtcc agctgtccaa aacagtgttg ataggagttc atcatagctg     2220

ctttgggagg aagccagatt ctccttatct tttagcttta gatcgtggaa tccaggaagt     2280

agaacaatgt ctattgttgc taaagaaaga aagaaatggg ccgggtgtgg tggctcacgg     2340

ggagtaatcc cagcactttg cgaggccgag gtgggtgaat cacctgaggt cagaagttca     2400

cgaccagcct gaccaacatg gcgaaaccct gactctactg aaaatacaaa aattagctgg     2460

gcatggtggc atgcgcctgt cccagctact caggaggctg agacaggaga attgcctgaa     2520

cccaggaggc ggaggttgca gtgagccgag attgtgccac tgcactcaag cctgggcaaa     2580

agagccagac tctgtttcaa aaaaaaagaa aaaaa                                2615


<210> 765
<211> 1378
<212> DNA
<213> Homo sapiens

<400> 765
gaggcaggac tgcccggccc agccttggag gaagacttct gggcagaagc ggaacacagg       60

agcagagaca catagtcttg gctccagttt cgtttcagtt atgcccaccc tttcagtgtt      120

catggatgtg cccctcgccc acaagctaga gggcagcttg ttaaagacct acaaacaaga      180

tgattacccg aacaagatat tcttagccta tagagtctgc atgacaaatg aaggccatcc      240

ctgggtttct ctcgtggtgc agaagactcg actacagatt tcacaggatc cctccctgaa      300

ttatgagtac ttgcccacca tgggcctgaa atcattcatc caggcctctc tagcactcct      360

ctttggaaag cacagccaag ccattgtgga gaacagggta gggggtgtac acactgttgg      420

tgacagtggt gccttccagc ttggcgtcca gtttctcaga gcttggcata aggatgctcg      480

tatagtttac atcatctctt ctcaaaaaga actgcatgga ctcgtcttcc aggacatggg      540

ctttacagtt tatgaatact ctgtctggga ccccaagaag ctatgcatgg accccgacat      600

actcctcaat gtggtggagc agatcccaca tggctgtgtc cttgtgatgg ggaacattat      660

cgactgcaag ttgacaccaa gtgggtgggc aaagttgatg tccatgataa agagcaagca      720

gatattccca ttttttgata ttccctgtca aggtttatac accagtgact tggaagaaga      780

tactagaatc ttacaatact ttgtgtctca aggctttgag ttcttctgca gccagtctct      840

gtccaagaat tttggcattt atgatgaagg agtggggatg ctagtggtgg tggcagtcaa      900

caaccagcag ctgctgtgtg tcctctccca gctggaagga ttagcccagg ccctgtggct      960

aaaccccccc aacacgggtg cacgtgtcat cacctccatc ctctgcaacc ctgctctgct     1020

gggagaatgg aagcagagtc taaaagaagt tgtagagaac atcatgctaa ccaaggaaaa     1080

agtgaaggag aaactccagc tcctgggaac ccctgggtcc tggggtcaca tcaccgagca     1140

gagtgggacc cacggctatc ttggactcaa ctcccagcag gtggaatacc tggtcaggaa     1200

gaagcacatc tatatcccca agaacggtca gattaacttc agctgtatca atgccaacaa     1260

cataaattac atcactgagg gcatcaatga ggctgtcctc ctcacagaga gctcagagat     1320

gtgtcttcca aaggaaaaaa aaacactgat tggaataaaa ctttagtctt tgcaaaaa       1378


<210> 766
<211> 2945
<212> DNA
<213> Homo sapiens

<400> 766
cgccgcgccg cttcccccac ctcgcaccag acctctgaaa ttgccctcgg agactcggcc       60

tctcctataa ggacgatcgt cctctcagct ggagaacaag gccatgcctc agctcctacg      120

ccaggcggaa gcgggagagg aaggccgacc cccaagagcg ccccttcagg gggtccatcc      180

ggccttgatc tcagatgggg gggtgtttgc ggagggcggg gcatcgcctc aacagctggg      240

ggctgcatca tggcaggaac gagtttccct gagccacgga gctgcaggtc gcctcctcta      300

ctaccctgct acccggttac ctcttcgcct cttggtcgtc gagcagctcc ggctcggtcg      360

ccgccattac cacatcgcac tccgcggcag ccgccatctt accgccggga ccagagagct      420

gggtgggagg ccggcggtga agagcacttc cggttggagc atagagcagc tccgcggcgc      480

cgcgcccaga agggctccct cgggctcgtc taccagagag aggctccgct tggggccaga      540

gcggcctccc gcccccggat gtccacggtg gtctccgcgc cggggcggga gcccaggggc      600

tgtgccggtt gaaaactaag catggggaag agctgcaagg tggtcgtgtg tggccaggcg      660

tctgtgggca aaacttcaat cctggagcag cttctgtatg ggaaccatgt agtgggttcg      720

gagatgatcg agacgcagga ggacatctac gtgggctcca ttgagacaga ccggggggtg      780

cgagagcagg tgcgtttcta tgacacccgg gggctccgag atggggccga actgccccga      840

cactgcttct cttgcactga tggctacgtc ctggtctata gcacagatag cagagagtct      900

tttcagcgtg tggagctgct caagaaggag attgacaaat ccaaggacaa gaaggaggtc      960

accatcgtgg tccttggcaa caagtgtgac ttacaggagc agcggcgtgt agacccagat     1020

gtggctcagc actgggccaa gtcagagaag gtgaagctgt gggaggtgtc agtggcggac     1080

cggcgctccc tcctggagcc ctttgtctac ttggccagca agatgacgca accccagagc     1140

aagtctgcct tccccctcag ccggaagaac aagggcagcg gctccttgga tggctgaaga     1200

gctgccgttc ctctttcacg atcccagccc catttcagtg tctggggctc tggtagatgt     1260

gttgagggca aagtagagga caagctgtct ttcccagtca gccagggagc tccccgccag     1320

gccacgcccc agccactttg ctccctctca cctctgggaa gtgcaaatac tcttggttga     1380

catccccttc ctcagccctc ccagcctact ccccatccca gcttttagag gatctgctcc     1440

actgtctcct ggggcagttg tgggtcactg tcccttccag ctgccccaga caggaagcag     1500

agtcaccacg cagcagtgtc ccttcttggg tctgagttcc tattataggt aggggcccca     1560

ccctctgggc ttcccatcag cgacacacac acacttatgg caccagcctg gactccagaa     1620

aaagggtgtc caggtattgt gtgtatgcat ttagttgtgc acacacaaat atgctcctat     1680

actggcatta ggcgtctcct catccctcac cctgaccttt ctcctgtcct tttcttggct     1740

ggaagaagtt ggcctcctgg gagtgtagtt ttctgtttta aatcccccac ccctggctgg     1800

gctcagtggc tcacccctgt aatcccagca ctttgggagg ccaaggcggg tcgattactt     1860

gaggtcagga gttcacgacc agcctggcca acattgtgaa accccatctc tgccaaaaat     1920

acaaaagtta gccgggcgta gtggcacatg cctgtaatcc cagctacccg gggaggctga     1980

ggcaggagaa ttgcttgaac tcagaaggcg gaggctgcag tgagccgaga tcgtgccact     2040

gcactccagc ctggtcaaca gagcaagact ccatctcgaa gaaaaaaaaa aaaaattccc     2100

cacccctacc aattgtttta cttcctcttc ctgctcaggg agcagatggg cctcactggt     2160

tgagatggaa tagaataact gggctatgag tcaccagccc actttgtgac ccagcaagac     2220

ctttcccctc tctgggcatc agtttctcat ctgtaagatg accagagttg cttagatgat     2280

ctcctagatc ctttccagtt ctcttgattt cgtaaagcca atggcttctc cctctttaag     2340

gtgctatgcc aaccagccct ggaggctggg atctgccgct ccctccagcc accagggggc     2400

aggagtgcac tacctgctgt cagtcaccag agtggccgct cagtgcccag cccgccagcc     2460

tcgctcttgg aggctgctct ttatcctgcc tgtggttttc agctcagagc tggacttcta     2520

tttataagtt acctgtattt atatttatat gcccgctctc atggtgaagg ctggacaagg     2580

tgctcctctg gcccctcctt cttacctcag atgcctgaac agaacaaggc aaacccgtag     2640

cagcctctca ggagctgaca ggtcctcttt cggggctcag gagggtgggc acacacccag     2700

cggcctgcag agtaagctta ttacccacaa ctgtgcccgc tttgtgcttc taaggtgcac     2760

acctagccta ggtgagacac tgcagccagg caaccaccga cacacgcccc ttctcaaagc     2820

cagaggtgag tggggcaggt gcccggggct gggtgagtgg aattaggaca cacacaggct     2880

tgggcttcaa gttcatttat tgatgcattg gttggacaca ataaaaccac aattgttatc     2940

aaaaa                                                                 2945


<210> 767
<211> 5032
<212> DNA
<213> Homo sapiens

<400> 767
cttgattatg tgtgccctct ccgggcgccc gcgttagcgg ccgggtggag gtggggaggg       60

aagacgctga ggaggaggag gaggcggagg aggcggtgga ggggaggtgg ggggaatcag      120

caaggacatg gctcctgact cctgtgcgga acgtgagtga ctgagcggca aagcccgaat      180

ggtctctagc gaccggcccg tgtcactgga ggacgaggtc tcccatagta tgaaggagat      240

gattggaggc tgttgcgttt gctcagacga gagaggctgg gccgagaacc cgctggttta      300

ttgcgacggg cacggctgca gcgtcgcggt gcatcaagct tgctatggca ttgttcaagt      360

acccactgga ccgtggtttt gcaggaaatg tgaatctcag gagagagcag ccagagtgag      420

atgtgaactt tgtccccata aggatggagc tttaaaaaga acagataatg ggggttgggc      480

ccatgtggtt tgtgccctgt atattccaga ggtacaattt gccaatgttt ccacaatgga      540

accaattgtt ttacagtctg ttccgcatga tcgttataat aagacttgct acatttgtga      600

tgaacaagga agagaaagca aagcagccac tggtgcttgc atgacatgta ataaacatgg      660

atgtcgacag gctttccatg taacatgcgc tcagtttgcc ggactgcttt gtgaagaaga      720

aggtaatggt gccgataatg tccaatactg tggctactgt aaataccatt ttagtaagct      780

gaaaaagagc aaacggggat ctaataggtc atatgatcaa agtttaagtg attcttcctc      840

tcactctcag gataaacatc atgagaaaga gaaaaaaaaa tataaagaga aggacaaaca      900

caaacagaaa cacaagaagc agccagaacc atcacctgca ttggttccat ccttgactgt      960

tactacagaa aaaacttata caagcactag caacaactct atatctggat cattgaagcg     1020

cttggaagat actactgcac gatttacaaa tgcaaatttc caggaagtct ctgcacacac     1080

ctctagtgga aaagatgttt cagagactag agggtcagag ggcaaaggga agaaatcttc     1140

agctcacagc tcaggtcaaa ggggaagaaa gcctggtggt ggaagaaatc caggaacaac     1200

tgtgtcagca gctagccctt ttcctcaagg cagtttttca ggaactccag gcagtgtaaa     1260

gtcatcttct ggaagttcag tgcagtctcc ccaggatttc ctgagcttta cagactcaga     1320

tctgcgtaat gacagttact ctcactccca acagtcatca gcaaccaaag atgtacataa     1380

aggagagtct ggaagccagg aagggggggt aaatagtttt agtaccttaa ttggcctccc     1440

ttcaacctca gctgttactt cacagcctaa aagctttgaa aattcacctg gagatttggg     1500

taattccagc cttcctacag caggatataa gcgggctcaa acttctggca tagaagaaga     1560

aactgtaaag gaaaagaaaa ggaaaggaaa taaacaaagt aagcatgggc ctggcagacc     1620

caaaggaaac aaaaatcaag agaatgtttc tcatctctca gtttcttctg cttcaccaac     1680

atcatctgta gcatcagctg caggaagcat aacaagctct agtctgcaga aatctcctac     1740

attgctcagg aatggaagtt tacagagcct cagtgttggc tcatctccag ttggttcaga     1800

aatttccatg cagtatcggc atgatggagc ttgcccaaca actacgttct cagagttgct     1860

gaatgcaata cacaacggta tttataacag caatgatgta gcagtatcgt ttccaaatgt     1920

agtatctggc tcgggatcta gtactcctgt ctccagctct cacttacctc agcagtcttc     1980

tgggcatttg caacaagtag gagcgctctc tccctcagct gtgtcatctg cagcccctgc     2040

tgttgctaca actcaggcaa atactctatc tggatcttct ctcagtcagg caccatctca     2100

tatgtatggc aatagatcaa attcatcaat ggcagctctt atagctcagt ctgaaaacaa     2160

tcaaacagat caagatcttg gagacaatag ccgcaaccta gttggcagag gaagctcacc     2220

ccgaggaagt ctctcgccac gatcccctgt aagcagctta cagattcgct atgatcaacc     2280

aggcaacagc agtttggaaa atctgcctcc agtagcagcc agcatagaac agcttttgga     2340

gaggcagtgg agtgaaggac agcaattttt actagaacag ggtactccta gtgacatttt     2400

aggaatgctg aagtcattac accaacttca agttgaaaac cgaagattag aggaacaaat     2460

taaaaacttg actgccaaaa aggaacggct tcagttattg aatgcacagc tttcagtgcc     2520

ttttccaaca ataacagcaa atcctagtcc gtctcatcaa atacacacat tttcagcaca     2580

gactgctcct actactgatt ccttgaacag cagtaagagc cctcatatag gaaacagctt     2640

tttacctgat aattctcttc ctgtattaaa tcaggactta acctccagtg gacaaagtac     2700

cagcagctca tcagctcttt ctaccccacc tcctgctggg cagagtccgg ctcaacaagg     2760

ctcaggagtg agtggagttc agcaggtcaa tggcgtgaca gtgggggcac tagctagtgg     2820

aatgcagcct gtaacttcca ccattcctgc cgtgtctgca gtgggtggaa taattggagc     2880

tttgccaggt aaccaactgg caattaatgg cattgtagga gctttaaatg gggttatgca     2940

gactcctgtc acaatgtccc agaaccctac ccctctcacc cacacaaccg taccacctaa     3000

tgcaacacat ccaatgccag ctacactgac taacagtgcc tcaggactag gattactttc     3060

tgaccagcaa cgacaaatac ttattcatca acagcagttt cagcagttgt taaattctca     3120

acagctcaca ccagaacaac atcaagcctt tttgtatcag ttaatgcaac atcaccacca     3180

gcagcaccac caacctgaac ttcagcagct gcagatccct ggaccaacac aaatacccat     3240

aaacaacctt cttgcaggta cacaggcacc cccacttcac acagctacca ccaacccatt     3300

tctcaccatc catggagata atgcaagtca gaaagtagca agacttagtg ataaaactgg     3360

gcctgtagct caagagaaaa gttgacacct gagaaacatc tagaaattgc ctatcctgct     3420

gttctagcac ttcatctggc tgcctttgca gtccttttac tacagctatg aagaaacgca     3480

acaagaaact caatgcacaa caaaggatta attgctgcaa ggacattctt gtaaggcttt     3540

gattagtttt cttgttgctt tgttgcactg aaatggaatt cccatgcccc taccccttac     3600

cccagttttt tgaacatgga aagaaaattt aataactttt taaagtgaca taatttacat     3660

gcaatatgtt tatcaactca agaatttaat atagttggta cacaactagt tttgtttata     3720

aattggagat gcaaatagca aaactaaata cttgctccat ttacaaacta cttgatttta     3780

ttgtacaagt tgaaatatgc tcttttgttt gggttacagt atgcttgctc taagtcaaat     3840

tccaaggaac taatttcttc tcctggagtt gcattgattc agtattacaa atatatagca     3900

catcacctgg gacttggcaa tctttgttaa aaaaaaattt cctttctaat gggatttggc     3960

caattttggt aatgaagtta ggatggtaat gtctgcatct gctaaaggta attttctttt     4020

gagaattgct ttctttagtg ttaagaccta ctcatatttt gaagaaatct tgagttaagt     4080

gagttctgag gctgctgggg gaaccagatc aattcaaagc taaatacttc tttcagaaag     4140

gggccactgt ggaaagtgct ggtggggttt gcccttgatc aagtgcctcc attgtgctgc     4200

aagggctgta gacagcaggg tgggacagtc agtcctccga gcagcaggaa tcatcccgtc     4260

acctgcagcc ttcccatgct tccgccttta ttcagaactt tctgtgccac tgtagatagc     4320

tcaggcaaaa ctattacctg ggtatttatc cactaatgag tcacaagaaa aggagtggat     4380

ttggtaagaa tagagatttg ttttatttaa accacttccc attactgacc attaaaagct     4440

caccactaga gttcctgaaa caggtgaaac ctgtatgaca gcccttccac tttggggagc     4500

cacgcttttg atgtgacagt accgcagagt gattccccca ctgaggatgt catcatcaaa     4560

ctcttctttg gtgtgtgaat tattagtgga aaagacccag ctgtaattag acctccactg     4620

tgtacttagc tggaagaaca tgttaattct gcaatatgtt tcttggttaa acattgcaca     4680

gttcttacct catttctgta aataaagttt tgtgaatctg ttttgtattg tgacaaattc     4740

ataagataac attgatattt tgatttgtaa tatttctaat tggtagattt aattgaaaag     4800

taaaattaat ttatttttat atgttcaggg gaattttaaa gtcaaatctt ttgtagataa     4860

tttaaaaaat cagtgtggtt tattttactt atttaaccca ctggttgtta ttctgtaaca     4920

gtttgtataa atggtaaatt ttgaatgtgt tgttatttta cctagatgta aaattccaca     4980

tgtattaaaa tgtacaaaat gttttgttaa taaaatttaa taatgtttat aa             5032


<210> 768
<211> 5390
<212> DNA
<213> Homo sapiens

<400> 768
cagtcagttg gtctgggcac tgcagcaggc tcggctctgt cccagcactt gtctgggaga       60

aaagtggtgt tactcaccca gggagagtct ctctttctac cttccttctt tctcgatctc      120

cttgtgtgct tttgtgtttc tttatttctt ttcctttttt ttcttttttt ttttttgtta      180

cttaattata ttcctaatcc tggatgaagt tgctggattc tgcagcacaa gtcttcatga      240

acaagcagca ccgctcagag atttcacggc attcaaaggt cacagaactg ccactatggt      300

taaatgtctt gtttaatggt tgagaggtgt ggcgaaatct tgtttgagaa ccccgatcag      360

aatgccaaat gtgtttgcat gctgggagat atacgactaa ggggtcagac gggggttcgt      420

gctgaacgcc gtggctccta cccattcatt gacttccgcc tacttaacag tacaacatac      480

tcaggggaga ttggcaccaa gaaaaaggtg aaaagactat taagctttca aagatacttc      540

catgcatcaa ggctgcttcg tggaattata ccacaagccc ctctgcacct gctggatgaa      600

gactaccttg gacaagcaag gcatatgctc tccaaagtgg gaatgtggga ttttgacatt      660

ttcttgtttg atcgcttgac aaatggaaac agcctggtaa cactgttgtg ccacctcttc      720

aatacccatg gactcattca ccatttcaag ttagatatgg tgaccttaca ccgattttta      780

gtcatggttc aagaagatta ccacagccaa aacccgtatc acaatgctgt tcacgcagcc      840

gacgtcaccc aggccatgca ctgctacctg aaagagccaa agcttgccag cttcctcacg      900

cctctggaca tcatgcttgg actgctggct gcagcagcac acgatgtgga ccacccaggg      960

gtgaaccagc catttttgat aaaaactaac caccatcttg caaacctata tcagaatatg     1020

tctgtgctgg agaatcatca ctggcgatct acaattggca tgcttcgaga atcaaggctt     1080

cttgctcatt tgccaaagga aatgacacag gatattgaac agcagctggg ctccttgatc     1140

ttggcaacag acatcaacag gcagaatgaa tttttgacca gattgaaagc tcacctccac     1200

aataaagact taagactgga ggatgcacag gacaggcact ttatgcttca gatcgccttg     1260

aagtgtgctg acatttgcaa tccttgtaga atctgggaga tgagcaagca gtggagtgaa     1320

agggtctgtg aagaattcta caggcaaggt gaacttgaac agaaatttga actggaaatc     1380

agtcctcttt gtaatcaaca gaaagattcc atccctagta tacaaattgg tttcatgagc     1440

tacatcgtgg agccgctctt ccgggaatgg gcccatttca cgggtaacag caccctgtcg     1500

gagaacatgc tgggccacct cgcacacaac aaggcccagt ggaagagcct gttgcccagg     1560

cagcacagaa gcaggggcag cagtggcagc gggcctgacc acgaccacgc aggccaaggg     1620

actgagagcg aggagcagga aggcgacagc ccctaggggc cggcccaact tagacgcggc     1680

tctcctccgg cagggccccc agagggcaga agcagcgtgg aggggccctc acgcagcagc     1740

ccagccactt tctgagtgtt gtcctggggc tctttggaac gccatcttcc tcccacttac     1800

ctgcctcccc tccttttcgc aaatgtacag aagccatttg tcacctcagc attcgctgcc     1860

gaaatgagca actccattca gtaacgtggg agctgatccc acgggcaggc tctccctgct     1920

ccaggagaag actaggagga agaatgaggt gctcctgccg tgtccgcctt gttccgggtc     1980

gcactggaac aggcagcaat tcctaagtcc ggagcgtttg agcgtttgct atctgactgc     2040

tgatctgcgt gacagaaaca ccagcatatt tgcaacgcca aggatattgg tcttaagtgc     2100

aagagcacaa atgagagtgt gagagaaagt accttctatt ttaataataa tattattata     2160

aaaataataa atctttttaa cttttatatt ttatgcacta gacaatggat ctgcaacttt     2220

ggactaaggt cattcaatgt acccaaactt gaacaggggg ttcattgttt tgctattgac     2280

tttattatgc cactttgggg cagagacttg gcatcttcgc agtttaagaa accacgtttc     2340

ctatccaatc cgaagggaag gtgctgtaca gttcattcct ttgcaccatt agccaatctg     2400

tcttttatgg attctgtgac atgtttatat tcacccatgt acattttctg taaataccaa     2460

acgctactga ttcccatgcc aaaatacatg agtattatgg gattgctacc tgtataaaca     2520

atggcactgt gaaaatactg ttagttttaa tacaagagaa tgcatttgta aatatggtat     2580

agagtttatt aatatactat tgtttgcaga taaaggcctt aactttaaac atctttcatc     2640

ttctgaaagc tgcccaactt aaatcctcat agatgtcttt ctcaactgcc ttcccatgtt     2700

catctgtatg ttttccagct aaggtcacaa accaaaactg aataaagtct ttgaggaaac     2760

attttggaaa cttcacatgc attccgcttg agaccatagt gtttaatcta tggcaccaag     2820

catcgtttcc tcagattaat gagacccttc aacaagcctg aatcagtcac ttttcaacac     2880

agcgatgttt taacaagcca gctgctaagc ttgtgtttat gtgactcttg ttacagatca     2940

tggcggtgcg tcagcctcac aggagacata gcaggtctca gaaaccttct atgaccctgt     3000

catctaacca tcagggaatt ccctgctccc atgccacaca tttgtctatt atggctatag     3060

taccaaagta cttttggtgt ttggttggtg tgcatttctt tagtgtcgat agtaactgga     3120

tttttctttt tccttaatct catgtgaaca actacccaac tgtttagctg aagttcatat     3180

tatttaagta aagaaaatat ttcagtttta taacagactt taccttcctg gcaggtcatt     3240

gtagttaatt atgtctctag cttggagtgt caccttggaa tttcgttgcc attttttctc     3300

agacacctgg ccgtaaaatc agtttgttac agcattcttc tctaggctgc taaacgctgt     3360

gcattgaacc ttttctttag aagtttcagc gtaactaatg ttagatgaaa attgttgatg     3420

cccctttctt tttactttaa acaatgtggt agtgggagaa tgactgtttc tgccactatc     3480

aacctgatcc tcatgctgat agaatgacag ctagcactta tttcctaagt gcaactgttt     3540

tagagatttt tctcctaaca tgcaaaggaa atactgattg gcctataata agttcctata     3600

gggagactga ggcttgcaga attaaggttc aggggaaatt ttggaaagtt ggttgtattt     3660

tcattgaagt aggagagatt atcagatggt gctaaagaaa gtgtgaagat cttatgaaat     3720

aggtggatgg taagttgaaa ttattgatgt gggtaagaag ggaggttgtg gaaagttaac     3780

actagctttg tatttttttt tctgtaaaac tgtgaactga tatattttcc tttatcactt     3840

tagtattctg cagttctcag cttggtgagg ctccaaaaga gaatatgtca gatgtattcc     3900

tacttccaaa cctgtcttac tttggtttga tggtacacat agggcttttg aacagtctat     3960

ttttaatgta tatgaggtca aatcaaggaa ggcaattgct ggggacaaga aaagtagagg     4020

taggaaagaa gacactattt tagctaatgg ggtttcttgg gactaaaaaa tggctttgtt     4080

taaattataa ttatataata atttaaataa atgagattgg aggtattctt agtagttctg     4140

agttgatagt ttacattaca attaggtctt gaagaagagc tcacagagaa aaaactacca     4200

aatatccaat gggtaagccc atgatgtagc cactagtaca ataaaaatct gaagtaaaat     4260

gaggcataaa cttgatgcag ctgcctccct cattcaactg gggagttctt gagttcctca     4320

tttgttggta aaaagaaaaa gaatgtgaaa atgtctcttt ttttcttggc tattagtggc     4380

tgtcttgcaa tatttcaata ggagtccaat tactagttaa aacactggcg gggtgcggtg     4440

gctcacgcct gtaatcctag cactttggga ggccaagttg ggcagatcac aagttcaaga     4500

gatcgagacc attctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta     4560

gctgggcatg gcagtgcgtg cctgcaatcc cagctactca ggaagctgag gcaggagaat     4620

cgcttgaacc tgggaggtgg aagttgtagt gaactgagat cgcaccactg cactccagcc     4680

tggcaacaga gctagaatcc gtctcaaaca aacaaacaaa aaatcccaca gctattggat     4740

catccacaga ttttttcttt acaatcttgt tctccttgtc catggaccat caatagttga     4800

cttgccaggt ttaattcttt cattgcttga gaagaaagga atcaaaggac tgtgtgtagt     4860

aagctgacgg taaagttaag attaaattaa gacagagaga gaatacatat cactgccagg     4920

cctgatagga aaaatctgct cttcctttta ataacagtga tgaattgtca ggaccttatt     4980

taggaaaccc tgacctaccc ataactccct gctaggctaa gtagaaacca ggttatttct     5040

ccctgcttat ggctccccgc aaagggactt gcagcgtgtc ctgcaacttt gtcttcagat     5100

agtgcttcct acaaaactag gtcttgtttt gtaatctttt ctcgtgttga atcagatctg     5160

cttacttatt taggtttggt tatgagcttg tatctcactg tatttctcat gctttgttct     5220

tttaaacaaa tcctttaaac tgtgtcattt tgtatacaca tgtgaggttt gaaaaaaaaa     5280

aaaaaaaaaa aaagaactac cttgtgagtt ttgctcaaaa tgtggcctaa gtagccattg     5340

gcatgtctag atgaacaaat aaaaataaag ataatttctt taaaatatca                5390


<210> 769
<211> 6535
<212> DNA
<213> Homo sapiens

<400> 769
tgctgatcgc tcgtgccggt gcggccgtta accgcccttg ccggagccct aggctcaaaa       60

gcagcccctt acccttcctg ggcttccccc aacccctttc ccggtctgcc ctggggcatg      120

agcagcgatg gccggctgca tccctgagga gaaaacttac cggcgcttcc tggagctatt      180

cctgggcgag tttcgcggac cgtgcggcgg cggcgagccg gagccggaac ccgaacccga      240

acccgaaccc gaacccgagt ccgagcccga gcccgaacct gaactggtag aagctgaggc      300

ggccgaggct tcggtagagg aacccgggga ggaggcggcc acggtagccg cgacggagga      360

gggggaccag gagcaagacc cggagcccga ggaggaggcg gcggttgagg gtgaggagga      420

ggaggagggc gcggcgacgg cggcggcagc cccggggcac tcggccgtgc cgccgccgcc      480

gccccagctg ccgcctttgc ccccgctccc gcgaccgctg tcagagcgca tcacccgcga      540

ggaggtggag ggcgaaagcc tggacctgtg cctgcagcag ctctacaaat ataattgccc      600

ttcctttttg gctgctgctt tagccagagc cacatcagat gaagtccttc agagtgatct      660

ttctgcacat tatatcccaa aggaaacgga tggcacagaa gggactgtgg agattgagac      720

agtgaaattg gcccgttctg tcttcagcaa actacacgag atttgctgca gctgggtgaa      780

agacttcccc ctccgcagga gaccccagct ttattatgag acatcaatcc atgccatcaa      840

aaacatgcgc aggaaaatgg aggacaaaca tgtctgcatt cctgacttta atatgctctt      900

caacctagag gaccaggaag aacaagctta ctttgcagtg tttgatggcc atgggggagt      960

agatgctgct atttatgcct ccattcacct ccacgttaac ttagtccgcc aggagatgtt     1020

cccccatgat cctgctgagg ccctgtgcag ggccttccgg gtcactgatg agcggtttgt     1080

gcagaaagca gccagggaga gcttaagatg tgggaccaca ggagtggtga ctttcatcag     1140

aggcaacatg ctacatgtgg cctgggtggg tgattcccag gttatgcttg tgagaaaggg     1200

ccaagctgtt gaactaatga agccacacaa accagacaga gaggatgaaa agcagagaat     1260

tgaggccctt ggaggttgcg tagtctggtt tggtgcctgg agggtgaatg gaagtctgtc     1320

ggtttccaga gctattggag atgctgaaca taagccatat atctgtgggg atgcagattc     1380

tgcctccact gttctggatg ggaccgaaga ctacctcatt ctggcctgtg atggcttcta     1440

tgacaccgtg aaccctgatg aggcagtgaa agttgtgtcc gaccacctga aagagaataa     1500

tggagacagc agcatggttg cccacaaatt agtggcatca gctcgtgatg ctgggtcaag     1560

tgataacatc acggttattg tggtattcct gagggacatg aacaaagctg taaatgttag     1620

tgaggaatca gattggacag agaactcttt tcaaggaggg caagaagatg gtggggatga     1680

taaggagaat catggagagt gcaaacgccc ttggcctcag caccagtgct cagcaccagc     1740

cgacctaggc tatgatgggc gtgtggattc attcactgat agaactagcc tgagcccagg     1800

gtcccaaatc aacgtgctgg aagacccagg ctacctagat ctcacacaaa tagaagcaag     1860

caaacctcac agtgcccagt ttttgctacc agttgagatg tttggtcctg gtgcaccaaa     1920

gaaagcaaat cttattaatg agttaatgat ggagaaaaaa tcagttcagt catcattgcc     1980

tgaatggagt ggtgctggag agtttcccac tgctttcaat ttgggttcaa caggggagca     2040

gatatacaga atgcagagct tgtctcctgt ctgttcaggg ttggaaaatg aacagttcaa     2100

atccccggga aacagagttt ctagattgtc tcatttacgc caccactact caaagaagtg     2160

gcacagattc aggtttaatc caaagtttta ttcatttctc tctgctcaag agccttccca     2220

caaaataggc actagcctgt cctcacttac tggaagtggg aagagaaata ggataagaag     2280

ttctctgcca tggaggcaaa atagttggaa agggtacagt gaaaacatga ggaagctcag     2340

aaagactcat gatattccat gcccagatct tccttggagc tataaaatag aataattttt     2400

ctttcaagta ggttagctag ctctccccca ataaaaatac cactatcaga gtagaaacaa     2460

ggtagacatt tctaaaacat atgtgcttca ttatgaatcc atggatggct caattcttaa     2520

atgtaaatag atctctagga aactcaaagt acagtgtttt caatctaaaa agaagtattg     2580

gcagtttcac ttgcaaaatt acacagctgg tccctgtgat gtgtctcgac accaatacac     2640

aacccccttc ccaccatcct tcatgtcact agatacacaa cccccttccc accatccctt     2700

cagtcactag tggaagcttt caagttagtt atttcagtca ggatatacag tgttgaaatc     2760

tcaatgcagt tgaaatctgg tctgatgtgc ctaatttatc tgtggaaaat ttaatgctga     2820

attacatttg gttgggaaat gtccctcaaa atcctgggca ctatgaagga accccctgcc     2880

ccctcacctt tttgggtagg taaaagacta aaagccatat ggattttaac tgataacaat     2940

gaaagtggta aatcagtgta aaagtgtcat attctcagac ttgtgaggcg gtttatagtc     3000

agaaagattt acggattttt ttcctgtaac ataaaagatt gtgaactttt tttaattaaa     3060

aaatatttcc tagggctgta gttatttggg agtttcataa cctgttatgg tgcttttggt     3120

ggaaattttt attatttagc attttaggag accgctgtca actggtttta atctatgatg     3180

ctaatgtgtt ttccactgta ccctcatctc aggaataaaa ctgctttaac ggagatgatg     3240

tcaggtacaa atacactata gagtcaaaat accatttaca aagaaaatca aaagcatttc     3300

tatattttgt ctttttttag ttcagacagc aaaggcatgt actactataa aatacaaagt     3360

gattttagag aatgaaaaat gctactttta tcttctctaa aattatttcc cccaaggtag     3420

tgaagtaatt ggaatgaagg aggctgaaag tattgtctaa agtgagccca gaggccactg     3480

agaatgcaga ttactgacag ccaggtctgt ttagttgtaa ttggaagaca catgagtgtc     3540

ctgcttacat gtagcttcag actgcagaga caggacgtgt gcttttcatt tcaatattta     3600

gttatatttg atattttgaa actgtctgct ttttgctatt tctgcagttt caagttagtt     3660

agaagcatgt tgtcaactaa agacaacaaa ctatcagatt cattcattca gtgaagcagc     3720

ctctgattct ctaagagtca cgaatgtctt agtgttaccc tcccctagtc aacagcagac     3780

cagcctggcc aatgcctatg ggtggcccct ctggagtgct cactaacaag ggtgagtgct     3840

ctcgctaaga agtgtccccc gcctaatcat gtgtttatag gatagtacac gttccccagg     3900

cccataacag aggactaaaa tctctgaatt ttaaagacac agatgactgg catattttgg     3960

ataccagtat agctatatca aatagacaaa aacagcttca ctttagcaat gatcagattg     4020

ttaatctaca gattttattt tttaaaattt ggatgtaagt agagactttc agtatttgtt     4080

ttctcttgat tttgaagtca tttcttcttc tcacgtctgt gacaaatggt tgaaaaggag     4140

tcaacatggc cccaactata gtgccggaac cttttcatca ttctgaggct ttgccccaca     4200

catggtcctc actcatatct gtcaccttct gaagcctaga tcttgttaac ccatcaggtg     4260

cagtgtcagt ttcaaatcaa attatctaag aaaacaagaa aacaaaggca gcagactatt     4320

ggtacacatt atagtccaaa gtgcttagcg aagtaaaaaa aaaagctttt taaaatttct     4380

attgttgtct attggtaatg tttttgatca gaataaagag ggtaaaggga aaaagttact     4440

acacatgcta ggctttctca gtggggaaaa aaatggctgg atagaactgg gacaaacaca     4500

gacccatctt taggggtctg gattttgtag gtccgactac acagcagtgt taactcattt     4560

ctcatgccat tagctctcta caaaataaag caaagtagtt ctagtgtggt cgttataaac     4620

caatattgtg aaaaatagca actattcatt tgttcacaac atgcgtattt atagagtagt     4680

taggtaccat ttgtaaggta aatcctttaa aattctataa tacatactaa aatagtggtt     4740

attggtctga tatatgctgc tcttggttct ataaactaga taaaagcagt gctttgtgaa     4800

atgcagtgtt ctctcttaac gccactggtg ataggaagta gttcccttca gttcaaatcc     4860

tgtgccctta tttgctgctt gctgacgtaa gcaataagta accctctaac taatggtatc     4920

tacatatttc tgtaacttgt atttaatgat ggtgtacctg gtgattgtaa aaatattaga     4980

cagatataaa agtatctata taatatctat aaactgttaa tgctgaggta tagtctgtga     5040

attatgtgtt ttgtattttt attcattgtg taatttagtg gtggtgaaag ttctacactc     5100

aatccttaaa gagtggcagt atcccttttt caatttaaca tggtctgcat caatctgttt     5160

gcctgctaaa caagttagaa taggaaatag taaaataaat ccaaacaaga gtgtaatatt     5220

ggttagggaa acaaacttca ggtcaccaac tgaagtcatt acaaactcct tgtacattca     5280

ctgtgagttt caaagggagt cagtccctaa tttacaggtt tcctttgttc actttctaga     5340

tgtgtacttt tgagggacat gaggttaggc aacattacag caacacacac tggggctatt     5400

aatcccattt aggtctgtac taaagaggat gggtagaaac acatatgtat ataccttttc     5460

tttacctaga agtgccatcc attgtccttg aattattatg attaaagtta ctgttgcatt     5520

taggaggctc cttgaaagta acaccttttc caaggacaat ggcaacaatg tcaatgtcaa     5580

cactgagtct aattttgacc acatttatag tggtatagtg tcaatactgc attttcatga     5640

caaccacact ccactgttga aacactgtgc cagtgagaag tgcaacatcc agtgggcaga     5700

tgaaaatgat gcatggccaa gttcagtgtt tacagataaa actgctgtgg ttcaagtgct     5760

tccttcccca tcaaatcctt gataaggctt tgtgggaaaa tgatctaaat tattgtttta     5820

atttttaaac ctaatttatt cactcagtga acattcttac ctaagcaagg ctataaaagg     5880

gaatactaca gttttgtcca cactttaatt tgagaccatt tttctttgaa tcgtaagtta     5940

gcaaaagaaa tttttttcac ctttgaaaat cacgtgatgt taaaggacaa atgcccactc     6000

ttctattctg atctgcaaat agcttaaatg tctcttgcaa aacaaagtaa gataccacca     6060

gtattacaac acaatgattt tccagacaaa tggtatggtg ttgaaaaata actgttactt     6120

cttaaagcag cattttatct tctattttga agactattta ttgtaataat tagaaaacat     6180

gaaataggga actccagact gacacagcag ttgtttttga aaaggaaata aactttgatg     6240

aattagataa tccagataca tcattgtaaa ctcttactct aggtgctctt tggtgagaga     6300

caggctttgt tctcttgttc ataacatttc tctgcaaaga attctctatg gagtgaagcg     6360

aatgaagtga ataatttctt accaaataaa tttatcaatt tacaaatctg ctctacatct     6420

cacttttgag ttcagttgta gtcatgagtg atccttcata ttttattaaa agtgttcatt     6480

caggtaaggt gtatgttgaa attttgccaa ttatcttaat aaaacctggc aattt          6535


<210> 770
<211> 1829
<212> DNA
<213> Homo sapiens

<400> 770
gaggcgcgtg tggaagcgct tccgggcggt agcacgctgt gttggcggcg gctccccgct       60

tgcctcagct gcagcagcgg gaagctcggt ggcaagccct tgtagtcctg tgcgatggcg      120

tctcgatatg acagggcgat cactgtcttc tccccagacg gacacctttt tcaagttgaa      180

tatgcccagg aagcggtgaa gaaaggatcc accgcggtcg gaattcgagg taccaatata      240

gttgttcttg gggtagaaaa aaaatctgtt gccaagcttc aagatgaaag aactgtgagg      300

aaaatttgtg cccttgatga ccatgtctgc atggcttttg cagttttgac aatttttata      360

ggacttactg ctgatgctag agtagtaata aacagagccc gtgtggagtg ccagagccat      420

aagcttacgg ttgaggaccc agtcactgta gaatacataa ctcgcttcat agcaacttta      480

aagcagaaat atacccaaag caatggacga agaccttttg gtatttctgc cttaattgta      540

ggttttgatg atgatggtat ctcaagattg tatcagacag atccttctgg tacttatcat      600

gcttggaagg caaatgcaat aggccgaagt gctaaaactg ttcgagaatt tctagaaaag      660

aattacacag aagatgccat agcaagtgac agtgaagcta tcaagttagc aataaaagct      720

ttgctagaag ttgtccagtc tggtggaaaa aacattgaac ttgctataat aagaagaaat      780

caacctttga agatgtttag tgcaaaagaa gttgaattat atgtaactga aatagaaaag      840

gaaaaggaag aagcagagaa gaaaaaatca aagaaatctg tctaattctt aggatgacca      900

ctgggaggtc ttaatgtttt gttttattgt actgcctgag gttgtttagt gaaattttag      960

aggaaaacag ttattttgca gcattacatg cagtacttgt gtgatgtttt gagaatgcca     1020

gatctgtggc tgtcttcatt ctattacata gtcaaacata ggtttatgtg aagattttct     1080

ttgaaagggg atttcagtaa ttgttgagag cagtcataat tccacataag cctgagactc     1140

tataatttgt ccagtgtctt acttaccttc atatatgcaa atataatttt aaaaaatttt     1200

ttaattaaaa aaatttaata atttggtgat gtttgaatat tgactgtcag ttaaggacat     1260

agctattcca aataaactaa atataatatt gagctgcatt tctcaaagaa tgacaaaagc     1320

atccttatac tgatgagttc ttaaaatttt gtcagagcct tcttcatttt acaatatttt     1380

gttattttta ttttaccttt ttcattttac aatatttcgt tatttttatt ttaccttttt     1440

cattttacaa gttgcaatat attgtttcgt tcatggaaca aatataggct gaattcaaac     1500

atgcaattaa agcatgggaa gagcttctaa gggcatctta acaggatgct acatgaaaat     1560

aaggaaagaa attaatacat atcactttta gtttagattt ttattttatc tcaagtatgt     1620

ccagtgtgtt cggtttgtta catattccat gaaatatctg agtgtgtatt ttatgattgg     1680

tattatggaa ggcttattgg gggaacaaga aaaatataaa aagtgatctc tgcccacgga     1740

aaggatttaa tccaaatggt ccacaagagg aatgtgctta attcctacag tgagtttata     1800

tttttgaaaa taaaagctag taaatattc                                       1829


<210> 771
<211> 4595
<212> DNA
<213> Homo sapiens

<400> 771
gctcgggaaa ggggttcgga accggtctag gctcaagtta aatctccctc taaagagcca       60

acactggttt ctttggcgac tcggtttcta ctctaaacag gtcccgctcc acagtctggg      120

cgggcctgtg tgtgcgttga gtagcctcta gcgtgaaaac ttcatggtta aaagggaagt      180

accggaggca agaaatagct ttcgaggcac tggtttgtta gagtagtggt acgtagtgcg      240

ccgccctgaa cgggggctga gacgctgctt ttccagaagt gccagtgagg acgtggcaag      300

accgcctcgg acgtacgctt cctctacctc agcccgtcgg gttaggggcg cgggaggcgc      360

agaggctgct gggaacgcgc atgcgctcag cgcggcgggg agtccacctt taacgtccgc      420

gggcgcgggg tgtgtcgggt gtcgacggcg gcgctttgcg gccggtcgtg cgggtcgggc      480

gcgggcgggc gcggcggcag tggcgcgcac aggtgattga ctggccagct gcctgaagga      540

gcgccaggtc ctccttgctg gcaggtggcg aagcccattg gggcggcggt gcagaccgcg      600

gcggcggctg cggcggtctg gctcgggagg cgttcctggg gccaaggcca tggccccgcg      660

gctgcagctg gagaaggcgg cctggcgctg ggcggagacg gtgcggcccg aggaggtgtc      720

gcaggagcac atcgagaccg cttaccgcat ctggctggag ccctgcattc gcggcgtgtg      780

cagacgaaac tgcaaaggaa atccgaattg cttggttggt attggtgagc atatttggtt      840

aggagaaata gatgaaaata gttttcataa catcgatgat cccaactgtg agaggagaaa      900

aaagaactca tttgtgggcc tgactaacct tggagccact tgttatgtca acacatttct      960

tcaagtgtgg tttctcaact tggagcttcg gcaggcactc tacttatgtc caagcacttg     1020

tagtgactac atgctgggag acggcatcca agaagaaaaa gattatgagc ctcaaacaat     1080

ttgtgagcat ctccagtact tgtttgcctt gttgcaaaac agtaataggc gatacattga     1140

tccatcagga tttgttaaag ccttgggcct ggacactgga caacagcagg atgctcaaga     1200

attttcaaag ctctttatgt ctctattgga agatactttg tctaaacaaa agaatccaga     1260

tgtgcgcaat attgttcaac agcagttctg tggagaatat gcctatgtaa ctgtttgcaa     1320

ccagtgtggc agagagtcta agcttttgtc aaaattttat gagctggagt taaatatcca     1380

aggccacaaa cagttaacag attgtatctc ggaatttttg aaggaagaaa aattagaagg     1440

agacaatcgc tatttttgcg agaactgtca aagcaaacag aatgcaacaa gaaagattcg     1500

acttcttagc cttccttgca ctctgaactt gcagctaatg cgttttgtct ttgacaggca     1560

aactggacat aagaaaaagc tgaataccta cattggcttc tcagaaattt tggatatgga     1620

gccttatgtg gaacataaag gtgggtccta cgtgtatgaa ctcagcgcag tcctcataca     1680

cagaggagtg agtgcttatt ctggccacta catcgcccac gtgaaagatc cacagtctgg     1740

tgaatggtat aagtttaatg atgaagacat agaaaagatg gaggggaaga aattacaact     1800

agggattgag gaagatctag cagaaccttc taagtctcag acacgtaaac ccaagtgtgg     1860

caaaggaact cattgctctc gaaatgcata tatgttggtt tatagactgc aaactcaaga     1920

aaagcccaac actactgttc aagttccagc ctttcttcaa gagctggtag atcgggataa     1980

ttccaaattt gaggagtggt gtattgaaat ggctgagatg cgtaagcaaa gtgtggataa     2040

aggaaaagca aaacacgaag aggttaagga gctgtaccaa aggttacctg ctggagctga     2100

gccctatgag tttgtctctc tggaatggct gcaaaagtgg ttggatgaat caacacctac     2160

caaacctatt gataatcacg cttgcctgtg ttcccatgac aagcttcacc cggataaaat     2220

atcaattatg aagaggatat ctgaatatgc agctgacatt ttctatagta gatatggagg     2280

aggtccaaga ctaactgtga aagccctgtg taaggaatgt gtagtagaac gttgtcgcat     2340

attgcgtctg aagaaccaac taaatgaaga ttataaaact gttaataatc tgctgaaagc     2400

agcagtaaag ggcagcgatg gattttgggt ggggaagtcc tccttgcgga gttggcgcca     2460

gctagctctt gaacagctgg atgagcaaga tggtgatgca gaacaaagca acggaaagat     2520

gaacggtagc accttaaata aagatgaatc aaaggaagaa agaaaagaag aggaggaatt     2580

aaattttaat gaagatattc tgtgtccaca tggtgagtta tgcatatctg aaaatgaaag     2640

aaggcttgtt tctaaagagg cttggagcaa actgcagcag tactttccaa aggctcctga     2700

gtttccaagt tacaaagagt gctgttcaca gtgcaagatt ttagaaagag aaggggaaga     2760

aaatgaagcc ttacataaga tgattgcaaa cgagcaaaag acttctctcc caaatttgtt     2820

ccaggataaa aacagaccgt gtctcagtaa ctggccagag gatacggatg tcctctacat     2880

cgtgtctcag ttctttgtag aagagtggcg gaaatttgtt agaaagccta caagatgcag     2940

ccctgtgtca tcagttggga acagtgctct tttgtgtccc cacgggggcc tcatgtttac     3000

atttgcttcc atgaccaaag aagattctaa acttatagct ctcatatggc ccagtgagtg     3060

gcaaatgata caaaagctct ttgttgtgga tcatgtaatt aaaatcacga gaattgaagt     3120

gggagatgta aacccttcag aaacacagta tatttctgag cccaaactct gtccagaatg     3180

cagagaaggc ttattgtgtc agcagcagag ggacctgcgt gaatacactc aagccaccat     3240

ctatgtccat aaagttgtgg ataataaaaa ggtgatgaag gattcggctc cggaactgaa     3300

tgtgagtagt tctgaaacag aggaggacaa ggaagaagct aaaccagatg gagaaaaaga     3360

tccagatttt aatcaaagca atggtggaac aaagcggcaa aagatatccc atcaaaatta     3420

tatagcctat caaaagcaag ttattcgccg aagtatgcga catagaaaag ttcgtggtga     3480

gaaagcactt ctcgtttctg ctaatcagac gttaaaagaa ttgaaaattc agatcatgca     3540

tgcattttca gttgctcctt ttgaccagaa tttgtcaatt gatggaaaga ttttaagtga     3600

tgactgtgcc accctaggca cccttggcgt cattcctgaa tctgtcattt tattgaaggc     3660

tgatgaacca attgcagatt atgctgcaat ggatgatgtc atgcaagttt gtatgccaga     3720

agaagggttt aaaggtactg gtcttcttgg acattaatct ttgaatactt gctgactgct     3780

aagaaatgac cagaggggaa gaggagtttg acatgttagg gcattaaagc aaaggtggat     3840

ttaagaatta aaccattaca tgccccttcc aaaaggcaga aatccattca aacgtgactg     3900

tcccaaatgc cttatgtcaa ataaagcaga ttgcactgat ggacatcaga cttgaaggaa     3960

atgtttccaa ttttatattt aaggggggtg gtgggtggga gggggcaagt aaagacggaa     4020

caagtttagt agcagtaata gtaaatcatg tttacatatg agatttatag tcgtgggagg     4080

ggaataaagt tctgttatat ttccttgctc gagtttcata ccagatgcgt tggtccataa     4140

aggattgtat caagtagatg ggacaacatt ctgctctgaa cgaaaagtaa ttttagagac     4200

ataacctgct taccaatgcc tgtctttgat tcatattcta ctttcaataa agcatgaaag     4260

tgaagaactt gtcctaagtg tggaaaagtg tcttcagatt tagactcttc tccatgtcag     4320

ctgcagcgcc acccgcctta cacctgcccg gccgtctgtc tcttggtatt gggtaaagga     4380

gggggcacct gcatgtctcc tgcaatgagc aaggaattat gtctcatgtt ttgacttcag     4440

aggctttttg ctttggtgca tttcagaaag gatggagaac atttattatg tgtgaaagca     4500

tcctcttccg gttttgctgt tattcaaaag tgggaaatgt acctggcacg tttgaaaata     4560

aaaaatctga ctacctatca gaagagtaaa tcaga                                4595


<210> 772
<211> 4397
<212> DNA
<213> Homo sapiens

<400> 772
gtcggtgcct gcagggctct ccgtggccgc tcgggagagg tgctcttcgc tcaggctccc       60

ccggagactt gagggggtgc gcgctggcgt gcatggggcc tgttctgtcc ttggtttggg      120

gatgctccta aggggggaga aagggatacc tcgggtgctt ggaggtcgag agacggatac      180

gtaagtgcgc aagggccact gattagggca cgggaagggc tcgctagaat gagctcttaa      240

actggttggg tgtaagcggt tttgggctag tctaaaccaa acaactgaga ataaacgcgg      300

ggttcctgca ggttgagaga gtacctgtct gcaaatgtcc agtagtgatg gattgccttg      360

taggccccag agcaatcggg gaagttagca ttcttgttca agaagctgct ggttcactta      420

gagctataaa agaatgttgt gagtttggat tttcttccaa acgttcagga ttgaggttag      480

ggctggtggt gagggatcat gtaaagaggt ttgagtggct cagccttagg tcccggtgtg      540

gaaagcttat tcttttggtg tcatcacgtg gccgtgggaa ttatttagaa tgtgatctgc      600

cctcatgaga agaaaggagc tctgaagccg ttgcagttct tcctccctat gtggaaaatc      660

gaatttctgg aaacatcctc cgtattggga gattttgcct atgtaaaggc tatccttatt      720

ggctagcggc actaattact ttaaaagtag gatggaagta caagtatctc aagcatcatt      780

gggtttcgag ctcacttctg tggaaaagag tttaagggag tggtctagac tttccaggga      840

agttattgcc tggctgtgtc cctctagtcc taattttata cttaactttc ccccacctcc      900

ttcagcctca tctgtttcaa tggtgcaact cttttcatcc ccttttggtt accagtcacc      960

ttcaggccat tcagaggagg aaagagaggg gaatatgaag tcagccaagc cccaagtgaa     1020

ccacagtcag catggggaaa gccagcgggc cttgagcccc ctgcagtcta ctctgagttc     1080

tgctgcatct ccttcccaag cgtatgagac ctatattgaa aatggactca tatgccttaa     1140

acacaaaatt agaaacatcg agaaaaagaa gctcaaactg gaggattata aggatcgcct     1200

gaaaagtgga gagcatctta atccagacca gttggaagct gtagagaaat atgaagaagt     1260

gctacataat ttggaatttg ccaaggagct tcaaaaaacc ttttctgggt tgagcctaga     1320

tctactaaaa gcgcaaaaga aggcccagag aagggagcac atgctaaaac ttgaggctga     1380

gaagaaaaag cttcgaacta tacttcaagt tcagtatgta ttgcagaact tgacacagga     1440

gcacgtacaa aaagacttca aagggggttt gaatggtgca gtgtatttgc cttcaaaaga     1500

acttgactac ctcattaagt tttcaaaact gacctgccct gaaagaaatg aaagtctgag     1560

acaaacactt gaaggatcta ctgtctaaat tgctgaactc aggctatttt gaaagtatcc     1620

cagttcccaa aaatgccaag gaaaaggaag taccactgga ggaagaaatg ctaatacaat     1680

cagagaaaaa aacacaatta tcgaagactg aatctgtcaa agagtcagag tctctaatgg     1740

aatttgccca gccagagata caaccacaag agtttcttaa cagacgctat atgacagaag     1800

tagattattc aaacaaacaa ggcgaagagc aaccttggga agcagattat gctagaaaac     1860

caaatctccc aaaacgttgg gatatgctta ctgaaccaga tggtcaagag aagaaacagg     1920

agtcctttaa gtcctgggag gcttctggta agcaccagga ggtatccaag cctgcagttt     1980

ccttagaaca gaggaaacaa gacacctcaa aactcaggtc tactctgccg gaagagcaga     2040

agaagcagga gatctccaaa tccaagccat ctcctagcca gtggaagcaa gatacaccta     2100

aatccaaagc agggtatgtt caagaggaac aaaagaaaca ggagacacca aagctgtggc     2160

cagttcagct gcagaaagaa caagatccaa agaagcaaac tccaaagtct tggacacctt     2220

ccatgcagag cgaacagaac accaccaagt catggaccac tcccatgtgt gaagaacagg     2280

attcaaaaca gccagagact ccaaaatcct gggaaaacaa tgttgagagt caaaaacact     2340

ctttaacatc acagtcacag atttctccaa agtcctgggg agtagctaca gcaagcctca     2400

taccaaatga ccagctgctg cccaggaagt tgaacacaga acccaaagat gtgcctaagc     2460

ctgtgcatca gcctgtaggt tcttcctcta cccttccgaa ggatccagta ttgaggaaag     2520

aaaaactgca ggatctgatg actcagattc aaggaacttg taactttatg caagagtctg     2580

ttcttgactt tgacaaacct tcaagtgcaa ttccaacgtc acaaccgcct tcagctactc     2640

caggtagccc cgtagcatct aaagaacaaa atctgtccag tcaaagtgat tttcttcaag     2700

agccgttaca ggctacttct tctccagtta cttgtagctc aaatgcttgc ttggttacta     2760

ccgatcaggc ttcttctgga tctgaaacag agtttatgac ctcagagact cctgaggcag     2820

caattccccc aggcaagcaa ccgtcttcac tagcttctcc aaatcctccc atggcaaagg     2880

gctctgaaca gggcttccag tcacctccag caagtagtag ttcagtaacc attaacacag     2940

caccctttca agccatgcag acagtattta acgttaatgc acctctgcct ccacgaaaag     3000

aacaagaaat aaaagaatcc ccttattcac ctggctacaa tcaaagtttt accacagcaa     3060

gtacacaaac accaccccag tgccaactgc catctataca tgtagaacaa actgtccatt     3120

ctcaagagac tgcaaattat catcctgatg gaactattca agtaagcaat ggtagccttg     3180

ccttttaccc agcacagacg aatgtgtttc ccagacctac tcagccattt gtcaatagcc     3240

ggggatctgt tagaggatgt actcgtggtg ggagattaat aaccaattcc tatcggtccc     3300

ctggtggtta taaaggtttt gatacttata gaggactccc ttcaatttcc aatggaaatt     3360

atagccagct gcagttccaa gctagagagt attctggagc accttattcc caaagggata     3420

atttccagca gtgttataag cgaggaggga catctggtgg tccacgagca aattcgagag     3480

cagggtggag tgattcttct caggtgagca gcccagaaag agacaacgaa acctttaaca     3540

gtggtgactc tggacaagga gactcccgta gcatgacccc tgtggatgtg ccagtgacaa     3600

atccagcagc caccatactg ccagtacacg tctaccctct gcctcagcag atgcgagttg     3660

ccttctcagc agccagaacc tctaatctgg cccctggaac tttagaccaa cctattgtgt     3720

ttgatcttct tctgaacaac ttaggagaaa cttttgatct tcagcttggt agatttaatt     3780

gcccagtgaa tggcacttac gttttcattt ttcacatgct aaagctggca gtgaatgtgc     3840

cactgtatgt caacctcatg aagaatgaag aggtcttggt atcagcctat gccaatgatg     3900

gtgctccaga ccatgaaact gctagcaatc atgcaattct tcagctcttc cagggagacc     3960

agatatggtt acgtctgcac aggggagcaa tttatggaag tagctggaaa tattctacgt     4020

tttcaggcta tcttctttat caagattgaa agtcagtaca gtattgacaa taaaaggatg     4080

gtgttctaat tagtgggatt gaaggaaaag tagtctttgc cctcatgact gattggttta     4140

ggaaaatgtt tttgttccta gagggaggag gtccttactt ttttgttttc cttcctgagg     4200

tgaaaaatca agctgaatga caattagcac taatctggca ctttataaat tgtgatgtag     4260

cctcgctagt caagctgtga atgtatattg tttgcactta atccttaact gtattaacgt     4320

tcagcttact aaactgactg cctcaagtcc aggcaagtta caatgccttg ttgtgcctca     4380

ataaaaaagt tacatgc                                                    4397


<210> 773
<211> 1513
<212> DNA
<213> Homo sapiens

<400> 773
agggaggagc cggaaactca gggcgcgagg cctgtgggcc cagcggtgag gcagcagctg       60

ggggcggggg gagggcggac ctagcttccc agggcaggtg attcgtcggc cccggtggcg      120

gcggcgcgtg cgacggtcac ctcggtttgg ggaagatgga agagttgagt caggccctgg      180

ctagtagctt ttctgtgtct caagatctga acagcacagc tgccccacac ccccgcctat      240

cccagtacaa gtccaagtac agttccttgg agcagagtga gcgccgccgg aggttactgg      300

aactgcagaa atccaagcgg ctggattatg tgaaccatgc cagaagactg gctgaagatg      360

actggacagg gatggagagt gaggaagaaa ataagaaaga tgatgaagaa atggacattg      420

acactgtcaa gaagttacca aaacactatg ctaatcaatt gatgctttct gagtggttaa      480

ttgacgttcc ttcagatttg gggcaggaat ggattgtggt cgtgtgccct gttggaaaaa      540

gagcccttat cgtggcctcc aggggttcta ccagtgccta caccaagagt ggctactgtg      600

tcaacaggtt ttcttcactt ctgccaggag gcaacaggcg aaactcaaca gcaaaagact      660

acaccattct agattgcatt tacaatgagg taaaccagac ctactacgtt ctggatgtga      720

tgtgctggcg gggacaccct ttttatgatt gccagactga tttccgattc tactggatgc      780

attcaaagtt accagaagaa gaaggactgg gagagaaaac caagcttaat ccttttaaat      840

ttgtggggct aaagaacttc ccttgcactc ccgaaagcct gtgtgatgtg ctatctatgg      900

atttcccttt tgaggtagat ggacttctct tctaccacaa acagacccac tacagccccg      960

gaagcactcc cttggtgggc tggctgcgcc cctacatggt gtcagatgtc cttggtgtag     1020

ctgtgccggc tggcccgctg accaccaagc cagactatgc tgggcaccag ctccagcaga     1080

ttatggagca caagaagagc cagaaggaag gcatgaagga gaaactcaca cacaaggcct     1140

ctgagaatgg gcactatgaa ttggagcacc tgtctactcc caagttgaag ggttcttccc     1200

atagcccaga ccaccctgga tgcctcatgg agaattaaag agagaagcct ccttaaggag     1260

ccacaggatg gtacctggcc ccaaaaggaa tcctggagag gaggacagtg acaacaggtg     1320

acttcattct ttagagtgaa ctttccaaac ccagtccagc tggaaacagc ttatctataa     1380

tctgaaatgc tggctcaaac agttatgggg aggttcccag attgcgtagc attcagattg     1440

atttgagcag ctcctactgt gataagtgta tcccagatcc acaatgtaaa tatatgtgat     1500

ttgtaagaaa gaa                                                        1513


<210> 774
<211> 2446
<212> DNA
<213> Homo sapiens

<400> 774
ctcattcata aacctctaaa gagagcaatc actacactta tggctgggat tttgcgctta       60

gtagttcaat ggcccccagg cagactacag actgtgacaa aaggtgtgga gtctcttatt      120

tgtacagatt ggattcgtca caaattcacc agatcaagaa ttccagaaaa agtgtttcag      180

gcctcacctg aagatcatga aaaatacggt ggggatccac agaaccctca taaactgcat      240

attgttacca gaataaaaag tacaagaaga cgtccatatt gggaaaaaga tataataaag      300

atgcttggat tagaaaaagc acatacccct caagttcaca agaatatccc ttcagtgaat      360

gcaaaattga aagtagttaa gcatttgata agaatcaagc ccttgaagtt gccacaagga      420

cttccagcag aggagaacat gtctaacacg tgcctcaaaa gcactgggga gttagtagtg      480

cagtggcatc tgaaacctgt ggagcagaaa gcacatgagt cctaatgccc cagcagcttc      540

cgattggaaa atgcaaattg tttttattta aagatggtga gaaagtgttt tcattaaaat      600

atgttttcaa aaccattttc aggccgggca cggtggctca cctgtaatcc cagcactttg      660

ggaggccaag gcgggcagat cacctgaggt caagagttcg agaccagcct gaccaacatg      720

gagaaacccc catctctact gaaaatacag aattagccag gcatggtggc acatgcctgt      780

aacccagcta ctcgggaggc tgaagcagga gaatcacttg aacccgggag gcagaggttg      840

cagtgagctg agatggtgcc actgtactcc agcctgggtg ataggatgag actccatctc      900

aggggaaaaa aaaaaatttt tttttcactg actaaacctg ctgcagctct cttttactac      960

agacttggag attttagttt aatttggttt aattctctgt cctttccctt tcactgtttc     1020

actccaaaac atgtaagaat ggcaatgttt gaacatctgc gtttgggtct actgccacct     1080

tagcaagcct cattaaccat tttataaaaa ttgcgttagt attgttgttg ttgtttttga     1140

gacagggtct tgctctgtca cccaagctgg aatacagtgg catgatttca gttcactgca     1200

gcctcgacct cccaggctca agtgatcctc ccacctcagc ctccagagta gctaggacta     1260

caggcagtgt gccaccacat ccagctaatt ttttaaagtt ttttcataga gacagggact     1320

cactatgttg tccaagctgg tctcaaactc ctgggttcaa gccatcctcc cacctcagcc     1380

tcccaaaatg ctgggattac aggcatgagc cactgtaccc agccaaaatt gttttctttt     1440

ttaagtgaat tcaacaattt ctgtgagtgg ctctttgcat gaacactgtg caaggtgttg     1500

gagaaatcca aagctgacca aaacatggtc cccacctttt ggagcttaca gtctgttctg     1560

gggaacagag attcagccaa agtcaagaaa cactggatgc cagctagatt atctgttctg     1620

tgctttggtg tctataagta catatgtgga tatgggttca ttttatccct aaacttagta     1680

ccaaaccagc atttaatatc taattataaa tctaatttgg cctaaacttt attattgcac     1740

actgcctgaa caaaacctat ttgtctctat gtaaattttt tcctcatgga acaagggtgt     1800

gaaatgaaaa tattttagga tttattcaaa aacagactat tctgttttca gcttcagaat     1860

tgttctttga atcctaagga acctctgtca acagttgagg ttgctgttga aaagaaagaa     1920

gaaggaggcg gaaatctctc agggagaatt atttcctttc ttttctattt tagatacctg     1980

gaggggtggg gagaagtaag aattgtaagg gaggttcagt agtggggaat tctgtgacag     2040

ctgattgaag atgatgatga agaacctctg cattctagtt accctttgct tcccttcacc     2100

tcttgtaaaa tttggcttgg caacaatgac attgtcatgc ttattgtccc aatatccatc     2160

ctgtcgtaga tcttaatgtt tttgatcgtt gcgttaaagt ggaagtgcca cccacagtga     2220

aaccagatcc cattaataaa taagcttaaa ggcaactgca gttttaattc catagttatt     2280

gaatatccag tgtgtgtaag gcctggaggg gagccaaagg acactaactt ctaagagctc     2340

cgtctagttg gagagaaacc tgtgtgccac aacatacagt gtccttgctt atgtggggtc     2400

gaagacatct gtgaaaataa aagcagcctc tgctaattta gcgcca                    2446


<210> 775
<211> 1699
<212> DNA
<213> Homo sapiens

<400> 775
tcaggaagtc ggcgtgtcga gtggctcttc ctggctgctg aggcgggtta aggtctgagg       60

gtcttgtggg gccacggcgc tgatcaccag gtgtttggct tggtcggttc ttatttctcg      120

cctggcaatg gcgacgtaca cctgcataac ttgccgggtg gcgttccgcg acgcggacat      180

gcagcgggcc cactataaga cggactggca ccgctacaac ctgcggcgga aggtggccag      240

catggcccca gtgaccgccg agggcttcca ggagcgagtg cgggcgcagc gggccgtcgc      300

ggaggaggag agcaagggct cggccaccta ctgcaccgtt tgcagtaaga agtttgcctc      360

tttcaacgcc tacgagaacc acctcaagtc ccggcgtcac gttgagctgg agaagaaggc      420

cgtgcaggca gtgaatcgga aagtggagat gatgaatgaa aagaacttgg agaaaggact      480

gggcgtggac agtgtggaca aggatgccat gaacgcggcc atccagcagg ccatcaaggc      540

ccagccgtcc atgtctccca agaaggcgcc cccagcgcct gcaaaggagg ccaggaatgt      600

cgtggccgtg ggtactggtg gccgtgggac ccacgaccga gacccgagtg agaaaccacc      660

ccggctccag tggtttgaac agcaggcgaa gaagttggca aagcagcagg aggaggacag      720

cgaggaggag gaagaggacc tggatggaga cgattgggaa gatattgatt ctgatgaaga      780

attggaatgt gaggatactg aagcaatgga cgatgtggtg gagcaggatg cagaggagga      840

agaggctgag gaaggcccac cccttggtgc catccctatc acggactgct tattttgttc      900

ccatcattcc agctcgctga tgaagaatgt ggctcacatg accaaagacc acagtttctt      960

tattcctgat atagaatatc tttcagatat taagggactg attaaatact tgggagagaa     1020

agttggtgtt ggcaagattt gcttgtggtg caacgagaaa gggaagtcct tctactccac     1080

agaagctgta caggcacata tgaatgacaa aagccactgt aagctcttca cagatggcga     1140

tgctgctttg gaatttgcag acttctatga ttttaggagt agctatccag atcacaagga     1200

aggggaggac cccaataagg ctgaggagtt gccctcagaa aagaacttgg aatatgatga     1260

tgaaaccatg gaattgattc tgccttctgg tgccagagtg ggtcatcgct ccttgatgag     1320

atactacaaa cagcgatttg gcttgtcaag agctgtggca gttgccaaaa atcggaaggc     1380

cgtgggccga gtacttcagc agtacagagc cctgggatgg actggcagca caggagcggc     1440

tcttatgcga gagcgagaca tgcagtatgt ccaaaggatg aaatcaaaat ggatgctgaa     1500

gacaggaatg aagaacaatg ccaccaagca gatgcacttt cgggtccaag tgagattctg     1560

agagtctgct gggattgagc aatcatctcc tgcccaagtt tcctccttgc cctgaggacc     1620

agtgaaagac agatcatagg agagaccctt ttgctgctac ttcattcgtt ctgacctaat     1680

aataaaagtt agaaccata                                                  1699


<210> 776
<211> 3326
<212> DNA
<213> Homo sapiens

<400> 776
ggggtcctgg cgagaagcga gccggcggcc tgaggaggcg actgactgag cagcgcaccc       60

ggggagcaag gaggcgcggt gaactgagcg gcccctgagc tgacagatac actgcgcagc      120

tggaacggcg agcgagccga cgggcgagtg aggggcgcag ccatgatcac ctcggccgct      180

ggaattattt ctcttctgga tgaagatgaa ccacagctta aggaatttgc actacacaaa      240

ttgaatgcag ttgttaatga cttctgggca gaaatttccg agtccgtaga caaaatagag      300

gttttatacg aagatgaagg tttccggagt cggcagtttg cagccttagt ggcatctaaa      360

gtattttatc acctgggggc ttttgaggag tctctgaatt atgctcttgg agcaggggac      420

ctcttcaatg tcaatgataa ctctgaatat gtggaaacta ttatagcaaa atgcattgat      480

cactacacca aacaatgtgt ggaaaatgca gatttgcctg aaggagaaaa aaaaccaatt      540

gaccagagat tggaaggcat cgtaaataaa atgttccagc gatgtctaga tgatcacaag      600

tataaacagg ctattggcat tgctctggag acacgaagac tggacgtctt tgaaaagacc      660

atactggagt cgaatgatgt cccaggaatg ttagcttata gccttaagct ctgcatgtct      720

ttaatgcaga ataaacagtt tcggaataaa gtactaagag ttctagttaa aatctacatg      780

aacttggaga aacctgattt catcaatgtt tgtcagtgct taattttctt agatgatcct      840

caggctgtga gtgatatctt agagaaactg gtaaaggaag acaacctcct gatggcatat      900

cagatttgtt ttgatttgta tgaaagtgct agccagcagt ttttgtcatc tgtaatccag      960

aatcttcgaa ctgttggcac ccctattgct tctgtgcctg gatccactaa tacgggtact     1020

gttccgggat cagagaaaga cagtgactcg atggaaacag aagaaaagac aagcagtgca     1080

tttgtaggaa agacaccaga agccagtcca gagcctaagg accagacttt gaaaatgatt     1140

aaaattttaa gtggtgaaat ggctattgag ttacatctgc agttcttaat acgaaacaat     1200

aatacagacc tcatgattct aaaaaacaca aaggatgcag tacggaattc tgtatgtcat     1260

actgcaaccg ttatagcaaa ctcttttatg cactgtggga caaccagtga ccagtttctt     1320

agagataatt tggaatggtt agccagagcc actaactggg caaaatttac tgctacagcc     1380

agtttgggtg taattcataa gggtcatgaa aaagaagcat tacagttaat ggcaacatac     1440

cttcccaagg atacttctcc aggatcagcc tatcaggaag gtggaggtct ctatgcacta     1500

ggtcttattc atgccaatca tggtggtgat ataattgact atctgcttaa tcagcttaag     1560

aacgccagca atgatatcgt tagacacggt ggcagtctgg gccttggttt ggcagccatg     1620

ggaactgcac gtcaagatgt ttatgatttg ctaaaaacaa acctttatca ggatgatgca     1680

gtaacagggg aagcagctgg cctggcccta ggtttggtta tgttgggctc taaaaatgct     1740

caggctattg aggacatggt tggttatgca caagaaactc aacatgagaa gattctgcgt     1800

ggtcttgcag ttggcatagc tttagtaatg tatgggagga tggaagaggc tgatgctctc     1860

attgaatctc tctgtcgtga caaggaccca attcttcgaa ggtctggaat gtatactgta     1920

gccatggctt attgtggctc tggtaacaac aaagcaattc gacgcctgct acatgttgct     1980

gtaagtgatg ttaatgatga tgtcaggagg gcagcagtag aatcacttgg gttcattcta     2040

ttcagaaccc ctgaacagtg cccaagtgtt gtctctttgt tgtcagagag ttacaaccct     2100

catgtgcgct acggagctgc aatggccttg gggatatgct gtgctggtac aggaaacaag     2160

gaagccatta atttgctaga accaatgaca aacgaccccg tgaactacgt gaggcaaggg     2220

gcactcatag cttcagctct catcatgatc cagcagactg aaatcacttg tccaaaggtg     2280

aatcagttca gacagctgta ttccaaagtc atcaatgata agcatgatga tgtcatggcc     2340

aagtttggcg ctattctggc ccagggcata ctggatgcag gtggtcataa tgtcacaatc     2400

tccttgcagt ccaggactgg gcatactcat atgccttctg tggttggcgt ccttgtattt     2460

acccagtttt ggttctggtt tcctctttca cacttcctgt cattggctta tacccctacc     2520

tgtgtcattg gccttaacaa ggacttaaag atgccgaaag ttcagtataa atcgaactgt     2580

aaaccatcca catttgcata tcctgcccct ctggaagtac caaaagaaaa agaaaaggaa     2640

aaggtttcta ctgctgtatt atctataact gccaaggcta aaaagaagga aaaagaaaag     2700

gaaaaaaagg aggaggagaa aatggaagtg gatgaggcag agaaaaagga ggaaaaagag     2760

aagaaaaaag aacctgagcc aaacttccag ttattggata acccagcccg agttatgcct     2820

gcccagctta aggtcctaac catgccggag acctgtagat accagccttt caaaccactc     2880

tctattggag gcatcatcat tctgaaggat accagtgaag acattgagga gctggtggaa     2940

cctgtggcag cacatggccc aaaaatcgag gaggaggaac aagagccaga acccccagaa     3000

ccatttgagt atattgatga ttaagggcca gaggatctca cttgcttatc tgaagaagat     3060

tgtccaggct catattggga atgcttatga ggaaattcat gccgagacct gctattcaat     3120

gcatgtatcg ttgcctctgc actgacctga agaaccctgt ctccaagtct ttggttgaag     3180

agaagatata tgactgttga gtgtgctctt tcacagaact tggttttcaa ataaatataa     3240

gatctccaga tggacaagac atttgttttt cagcctgggt ttttaataaa tgtatctaat     3300

cctccccaca ccatgaaatg cctaaa                                          3326


<210> 777
<211> 1665
<212> DNA
<213> Homo sapiens

<400> 777
ctcttttcag gctgagtcct aaacctgaag aaagtttaga gcctggggct ctaaactacc       60

tgagtctttc caaacgacaa gccaagaaga cctgttgaaa gtttcctctt aagtttcgtg      120

gagagagact caggtataga aatatcctta ctgccacctg acctgaagca gaagaaatca      180

cagacagctt ccagaccagg cccaacatgt gtagcaccag tgggtgtgac ctggaagaaa      240

tccccctaga tgatgatgac ctaaacacca tagaattcaa aatcctcgcc tactacacca      300

gacatcatgt cttcaagagc acccctgctc tcttctcacc aaagctgctg agaacaagaa      360

gtttgtccca gaggggcctg gggaattgtt cagcaaatga gtcatggaca gaggtgtcat      420

ggccttgcag aaattcccaa tccagtgaga aggccataaa ccttggcaag aaaaagtctt      480

cttggaaagc attctttgga gtagtggaga aggaagattc gcagagcacg cctgccaagg      540

tctctgctca gggtcaaagg acgttggaat accaagattc gcacagccag cagtggtcca      600

ggtgtctttc taacgtggag cagtgcttgg agcatgaagc tgtggacccc aaagtcattt      660

ccattgccaa ccgagtagct gaaattgttt actcctggcc accaccacaa gcgacccagg      720

caggaggctt caagtccaaa gagatttttg taactgaggg tctctccttc cagctccaag      780

gccacgtgcc tgtagcttca agttctaaga aagatgaaga agaacaaata ctagccaaaa      840

ttgttgagct gctgaaatat tcaggagatc agttggaaag aaagctgaag aaagataagg      900

ctttgatggg ccacttccag gatgggctgt cctactctgt tttcaagacc atcacagacc      960

aggtcctaat gggtgtggac cccaggggag aatcagaggt caaagctcag ggctttaagg     1020

ctgcccttgt aatagacgtc acggccaagc tcacagctat tgacaaccac ccgatgaaca     1080

gggtcctggg ctttggcacc aagtacctga aagagaactt ctcgccatgg atccagcagc     1140

acggtggatg ggaaaaaata cttgggatat cacatgaaga agtagactga aatatcagat     1200

ttgtcatcag gaatactctt tgtctactgt ggtcctgtgc acgttggcct cagatggact     1260

acaggagatt acaacgtaca aggcagatgg agcattgacg ttttcaaaac cattattcct     1320

gtgactggag aggcatcagg agaggtctcg ttcgtctcca gctcataaaa tgtagcagca     1380

tcatccttga cagtgatgtt tttcaggccc tccattgaga acctgaggaa atctgtaaag     1440

ataagtggtg atgttgtttc aaacgttcag aacagatacc atcatcctgc ctttgttagc     1500

tgctgtaggg aaagtgcgtt acagatgtct gctgacctca caagagtgaa aagataaact     1560

gtgcatgtgt ttccacttcc gtttctagta ctatttattt ttaaactaca cttggggtgg     1620

cctaatacct aggaagatgt tgctattcac gttagtaaac agcct                     1665


<210> 778
<211> 3843
<212> DNA
<213> Homo sapiens

<400> 778
gttggagcgg cgctgctcgg ccgcggacac acgagggacg cgcccgagga gctgcaggtg       60

gcagcccagg cggtccgaac ccgtcggccg gccgagcctg gagtattgcc taagtgtaat      120

cttgaacatg ggcggtgctg tgagtgctgg tgaagacaat gatgagctga tagataattt      180

gaaagaagca cagtatatcc ggactgagct ggtagagcag gctttcagag ctatcgatcg      240

tgcagactat tatcttgaag aatttaaaga aaatgcttat aaagacttgg catggaagca      300

tggaaacatt cacctctcag ccccgtgcat ctactcggag gtgatggaag ccctagatct      360

gcagcctgga ctctcgtttc tgaacctggg cagtggcact gggtatctca gctccatggt      420

gggcctcatt ctaggtcctt ttggtgtgaa ccatggggtg gaacttcact cagatgtgat      480

agagtatgca aagcagaaac tggacttctt catcagaaca agtgatagtt ttgacaagtt      540

tgacttctgt gaaccttcct ttgttactgg gaattgcctg gagatttctc cggattgttc      600

tcagtatgat cgtgtatact gtggggctgg cgtgcagaaa gagcatgaag agtacatgaa      660

gaatcttctc aaagtgggag ggatccttgt catgccactg gaagagaagt tgactaagat      720

aacacgcaca ggtccttcag cttgggaaac caaaaagatt cttgctgttt cttttgctcc      780

tctgatccag ccctgccatt cagagtcagg aaaatcaaga cttgtccagt taccaccagt      840

ggcagttcgc agcctccagg acttggctcg catcgccatc cggggcacca ttaaaaagat      900

tattcatcag gaaactgtga gcaaaaacgg aaacggacta aagaacaccc ccaggtttaa      960

acgaaggaga gttcgccgcc gtcgaatgga aacgattgtc tttttggaca aagaagtctt     1020

tgccagtcgg atttccaacc cctcagatga caacagctgt gaagacttgg aagaggaacg     1080

gagggaagaa gaagagaaga ccccgccgga aacaaagcca gaccccccag tgaacttcct     1140

acgccagaag gtcctgagcc tccctctgcc agatcccctg aaatactact tgctttatta     1200

cagagaaaaa taagtctcct gtttgaaagg gggaaatagg aagagcagat tgctgagtgt     1260

gaagttcgtg ctgcctgtgt gctgttgaag ggtcacctgg aggcagacgt tgtggggaag     1320

ggaactgctg ggctcatcca caccatggtt ttcttctagt tcctgattga cctctaaaat     1380

tctattcagt tgtatgattt gtttacatag ttccacaaga ccttcattgc atagaagatt     1440

gttttcccaa agtggagaga atcttcatag agaaaaagag aaggctgttt ctttttcggc     1500

tctgacgaaa cactgaagtc tgcgtaagag agactgtttg atgaccgtcc ctcatgcaac     1560

atgcacggta ctcactaaaa atgaaaactg aagtggaaac taacctgtgt tgcttataaa     1620

gtgtgaaagc acaagcttat aaatgtataa aatcttttct gggtgtgacg cacctgcgtc     1680

caagtttgaa tttttatgat atgtaccact taattactgg cactgagtat cactgaattt     1740

cttagttttc tagtggggaa acattattga gaagccctcc cttattttaa gtaagttgat     1800

taaatcttat gtgagttgcc agttgtaatt tttcaaagga aaaattttga tggggtggag     1860

gaatgaattg ccagataatc tttctggaat tccgagagaa ttccaaagag ggtttttttt     1920

ttttttttta ggacatcttt tgataccttt aaaagaacca ctgtcaagta atccttaaaa     1980

gaatatcttg gaaaaggaaa cagatttttt cctgtgtgta agcaataagt gaagttacat     2040

ttgccctaac cctagggatg attctttacc cagttttaaa gcccatcatg gtattctaag     2100

gtgttgacac cctccatcct cagagcaggt cgaaaatatt aaatagactg gggactctat     2160

gatgggcagc ctgtgctttt tgacttcagt ttgctatttt tctgtgatca cattagtact     2220

gattcataga ttctatcttt tataattctg gagaaaaaga tttgttagtt ttgtaatttt     2280

tttgtaagac caaatgtatg tattttagta gctccattgc atgagaagag tgtaactcac     2340

actgacttgt gatatcagcc ttctctgggc cttgtgtgtg gagagctttc tatcttacca     2400

agtggtaggg ctaaaagaac aacagccttt ttggtagtca catagcagaa tgatcagagt     2460

tacattgctt attccaaaac attggttctt tttaaaacat ttttttttac ccaaagaaaa     2520

gaataataga aattactaac aataaatata aattcagagt gttgatatag gattcagtat     2580

ccagagttta tttttaatct taatcctcag cttcttggga gttgctgggc ttcagtgtct     2640

ctgtggtttc accagcttag cttgagctct ggttattttg gatcttttct gcttttttta     2700

agtaactgag tcatttttac cacacagtcc agtttgcatg tatagctagg aaacatgtat     2760

tgctctagat tgggcagttt aagtcatttt aaagaaagtt agttcatagt tgttgccttt     2820

taactcatag tcaagcttca gtctttcaaa gagaaatgtg tgattttcat ttacttgctg     2880

atattttgta gtttggagat ccttgtgggc attattctaa ctgatacgta gacacttact     2940

tggaaatttt tggacattat attaaatgag tgctatctgt gaaattggtt atattaggtg     3000

gcttgactaa tgttttttct ataattgtat atggactgca tttttaaaaa aaccgcattt     3060

gcctttatgc tagattgtaa aaaattatat tagaatgcat aagacatgtt tttccttcat     3120

atgctagact tttcctagca tttcgtattt ctgtgttgtc agtgtgtgat ttttaaaccg     3180

gaatttggtt taaaaaaaat ctggtggtaa tatatgtgag aaatactttg gtgtttacct     3240

tatgaaaata aaggattgta agtaaagttt cctgcgcacc ttataccaga attcagtata     3300

atacactact ttctgttttc aaacagataa atcataatat agtctgtatt atctgtaaga     3360

tctgtcttgt aaaccacatt cttgacaact atttgctttt gagtagtttg tattttaata     3420

tgtgactttt gtcttgaaaa gtagtaaagc catagacttg tgcaaaacaa gtttcaagtt     3480

tatagatatt aagtttgtaa tgtgagcatc aaatgtgtat gtaaaaatac tttttaccag     3540

tctggaactt gggaaaatcc agggaatttg aaacatagat tttaatgagc tggtaaacac     3600

aaatcatgtc aataaaggta gtcaggatat tttatcctta gcattgcttc tgcatcctgt     3660

gtaggattcc aattcttgaa tatgttcttt tcaaaatctt aagaaaagaa ccttttttct     3720

ttattaacat catgtgttta ctttcagcaa atatttgtat tactgcttga ttctgtgaca     3780

gtcacaatag atgtagagaa ggcattattt ttcattaata aatgtgaaat tggaatggac     3840

aaa                                                                   3843


<210> 779
<211> 6066
<212> DNA
<213> Homo sapiens

<400> 779
ccgcgcgcgc tcctcgggtc tgcgcggagc cggcgtcggc gcgcgcttgg gcgcctggcg       60

aagaccgaga gaggctggcg ggatctcagc ggcgcggccg cggaacctga ggcggtctgg      120

ggcggcggcg ctccggctct gaagggctcc agccaaacgg agcccgcggc caaacggtgc      180

ctgcggtgcc tgagctgagt gaggccgagg ccgggaggcc gtgcccggag taaggcgaaa      240

gagaatgaaa gacgtagata acctcaaaag tataaaagaa gaatgggttt gtgaaacagg      300

atctgataat caacctcttg gtaataatca acaatcaaat tgtgaatatt ttgttgatag      360

cctttttgag gaagctcaga aggttagttc caaatgtgtg tctcccgctg aacagaagaa      420

acaggtagat gtaaatataa aattatggaa aaacggattc accgtcaacg acgatttcag      480

aagttattcc gatggtgcca gtcagcagtt tttgaactcc atcaaaaagg gggaattacc      540

ttcagaatta cagggaattt ttgataaaga agaggtggac gttaaagttg aagacaagaa      600

aaatgaaata tgtttgtcta cgaagcctgt gttccagccc ttttcaggac agggtcacag      660

actaggaagt gccacaccaa aaattgtttc taaagcaaag aatattgaag ttgaaaataa      720

aaataatttg tctgctgttc cactgaacaa cttggaaccc attactaata tacagatctg      780

gttggccaat ggaaaaagga ttgtccagaa atttaacatt actcatagag taagccatat      840

caaagacttc attgaaaaat accaaggatc tcaaagaagt cctccgtttt ccctggcaac      900

agctcttcct gtcctcaggt tgctagatga gacactcaca ctggaagaag cagatttaca      960

gaatgctgtc atcattcaga gactccaaaa aactgcatct tttagagaac tttcagagca     1020

ctgatttttg atagactaag tggaaaattt gcagagaaat gatggttgta agtggacatg     1080

caaaccaaaa ttggggattg gagaagtcag actcactaga cttttggttc gagtactatt     1140

gaactctctc ctgatgagaa gatgtttaga taagtacaag ttaagaaagt agcatatgac     1200

tggaaactat attcagtgca ctttctccaa aagactaccc agaaaaatag acttattttc     1260

aaataccagt tatcaagata tattaaatag ctgtattgtt tagaatctta atatggtata     1320

aattagcata tgtattcaca atattcattc agacatcatt cccagacagc agggatttat     1380

ttaaatgtta gctgtctgag tttttaaata gctaatacga ccgggtacag tggttcatgc     1440

ctgtaatccc agaacttcgg gaggccgaga caggcagatc acgaggtcaa cagattgaga     1500

ccatcctggc aaacatggtg aaaccccatc tctagtaaaa atacaaaaat tagctgggcg     1560

tggcggtgcg caactgtagt cccagctact cgggaggctg aggcaggaga atctcttgaa     1620

cctggcaagt gtaggttgca gtgagctgag attgagcaac tgtactccag cttggcgaca     1680

gagcaagacc ccctctcaaa aataaataaa ataaagtaaa ataaatataa ataattgtgg     1740

ccgggtgcaa tggctcatgc ctgtaatccc agcactttgg gaggctgaga tgggaggatc     1800

acttgaagcc aggagtttaa aaccagaatg atcaacagag tgagacccct gtctatatat     1860

ttttttaatt taaaaaataa aagaataaaa ttgtgtagct cagtatagta tcaagattaa     1920

tctgcctact cacatttcta cactttataa aaatgtaata aaagaaaatt atctttctaa     1980

aaagcctatt ccctttccat tttattttct ttcaaaaatt atggatttgt ttttggctaa     2040

catttgggat tagccattca tttgccacca ctcacttaga atataatgcc ggtgtgtgtc     2100

acattactag tattttttaa atgcatcata taaagtatgg ttttctgttt ctttttcgtt     2160

tgtttgagat ggagtttcgc tcttgttgcc caggctggag tgcagtggcg caatctcagc     2220

tcaccacaac ctccacctcc cgggttcaag agattctcct gctcagcctc ccaagtagct     2280

gggattacag gcatgcgcca ccatgcttgg ctaattttgc atttttagta gacacgggat     2340

ttcaccatgt tggtcaggct ggtctcgaac tcccgacctc aggggatctg cctgcctagg     2400

cctcctgaag tgctgggatt acaagtgtga accaccgtgc ccagctggtt ttctgtttca     2460

tacatcagag tcaacttgtg aatacattta aagattattt cattttgata tcacgaagaa     2520

aaacaggctt tatatctcag actttaacta aatccagtta gacctcaatt tttcactgtc     2580

agattaaatc cccatacctg aaaataagtt taacattttt ttttgcaaat gatctattga     2640

atcagattta aaatgaagca tgcattgagt gtgccaagga actaagtggt ccatagcagc     2700

agtaatgttc atagggtgcg agatgcctgc tatgaaacag caactctcaa acatttttat     2760

ctcaagacca tttgtttatg tgagctatat atattattat attaaatatt aaatttttaa     2820

aatatttatt tatgggccag gcacggtggc ttacgcctgt aatcccagca ctttgggagg     2880

ctgaggcagg cggatcacaa ggtcaagtga ttgagaccat cctgtccaac atggtgaatc     2940

cccgtctcta ctaaaaatac aaaaaaaatt agctgggtgt ggtggcatgc gcctgtagtc     3000

ccagctacgt gggaggctga gggaggagaa tggcttgaac ccgggaggtg gaggtttcag     3060

tgagccgaga ttgcgcccct gcactccagc ctggtgacgg agcgagactc tttctcaaaa     3120

aaaaaaaatt attcatttaa aaataacttc tggctggaca tggtgtctca cgcctgtaat     3180

cctagcactt tgggaggcca agacaggtgg atcacttgag cccaggagtt tgagaccagc     3240

ctgggcaaca aggcaaaact ctatctataa aaattacaaa aattagtgca gtagctcaca     3300

cctgtaatcc cagcactttg ggacactaaa gcgggcagat cacctgaggt caggagttcg     3360

agaccagcct ggtcaatgtg gtgaaaccat gtctgtacta aaaatacaaa aattagcctg     3420

gtgtggtggc acatgcctgt aatctcagct actagggagg ctgagggagg agaattgctt     3480

gaactcagga ggcagaggtt gcagtgagcc gagattgcgc cactgcactc tagcttaggc     3540

aacagagtaa gaccctgccg taataataat aacttttttt tttttgagat agagttttgc     3600

tctttccccc agactagagt gcaatggcgc gatcttggct cactgcaact tgtccccccg     3660

ggttcaagcg attcttctgc cacagcctcc cgagtagctg ggattatagg cgcccactac     3720

cacgcctggc taatttttgt atttttagta gagacggggt ttcgccatgt tggcctggct     3780

ggcctctaac tcgtaacctc aggtgatccg cccgccttgg cctcccaaag tgctaggatt     3840

ataggcgtga gccactgtgc ccagccaata ataacttata aaacatgaaa cgatttagtg     3900

agaaaagtgg ccggtttttt ggggggaatt actttctgtc ataaagaaga tagatgggtt     3960

ctcatgtctt ctacattcag tctgttgtgc agtcacatat catgtagact ctggaaaaca     4020

cctctgtata ctggtgaaag aatgaaaaga agcaaataat gccttagtat gattatgaaa     4080

aacgttttga cttcacagtg ccctgaatgg gtcttgggaa tctccaggga tccctcaggc     4140

acactttgag aaccaatcta tataaagtga tggttcacaa tgattctgaa gccttagttt     4200

cagaatcatt tggggcagct tttcaaaaat gccattcctg ccacctacca caaagattct     4260

gattcactgt atctgtgatg ggtctcagat ctctgcattt ttaatctcac gtgattctta     4320

agtatgtggt ggaagtacct ttcttcagga aattctgtcc taagctttta ccctgagaaa     4380

ataaaacctg catgctttca ccatggacgg tgggagactc cactgaaaca catctgctag     4440

accactaagt ttatccttgt cacccagttt gctcttggaa agagtctgtt cccttttgtc     4500

actgaaccaa tcatgacata aacttgtgct ttacctccta tagcacagcc gagacaaggc     4560

tggaacattt aattaaggtt tttactaagg actcaggaat aacaacaggg aaatatctat     4620

gtaactagat gacctgacat aaaatctatc ttctgattgc agtctattgt gagaatgctg     4680

cttttcctag ctcccagcct tccatggggc agaaggctct tttaattagg aagagaggga     4740

ggacaaagga gagccttttc ttttgtccat tactcttaga aatgaacagg tacataatag     4800

aaaataaata attattgttg gtaatgttta cacagcagtg ttagagcctc tctgtagtga     4860

aacaaaaata atgttcttac caaaaaaaaa aaaaaaaaaa agaggcaatg ataaaatcaa     4920

tgagcttatc tttctgatat agaaaataac aggatgacag ttaatacatg ttcaggaatc     4980

taagaaaatg tttcatatag gcctatcatg tagcattttt atttgcataa ttatagtcaa     5040

catatgattc tccatgtagg ggtctctcat tgagaatgtt tcctgtgtac ctatagaaaa     5100

gcctctttgg tagattttcc ggtttataat tatttaacca gaagatacat gggaggttct     5160

tttgtatgta cctgtagaat acatcccagt aagggtccta tggagaaaga cctgttgtca     5220

tcaataacct tcattattct aactgtgaaa cgttcattaa tgcgaataat atcctcaaag     5280

attttctaca atgagaatca tccagtaaag ctttttaact gagaatttaa aagttgtaaa     5340

attgttagtt aaatgtgtat aattatcaaa agaggttgac tttggaaaac aaacaatttg     5400

ctaagggaag gaaaacttga aaataatcac cttagatggg gcatacaatt tgacctaagc     5460

aattgtttca aaactgtctt cagtttcttg aaaataattg ttagggctga tatatagaaa     5520

tacatatcta ggccaggcac ggtgactcat gcctgcaatc ccagcacttt gggaggctga     5580

ggtggatgga tcacgaggtc aagagatcga gaccatcctg gtcaacatgg ggaaaccccg     5640

tctatactaa aaatacaaaa attagctggg tgtagtggtg tgcgcctgta gtcccagcta     5700

ctcaggaggc tgaggcagga gaatcacctg agccccggag gcagaggttg cagtgagccg     5760

agatcgtgcc actgcactcc agcctgggca acagagcgag actccgtctc aaaaaaaaga     5820

aaaaaagaaa tacatatcta atgttacaga ttgtggttta ttggttaatt actatgcatt     5880

tttttcagtt taaaaaataa tcttatttta tatacttctc tcggtataat ttttcatgac     5940

atttcagcat gttgataata tgtgtgcatc tatttcagtg ccttaaagta ttttgagagc     6000

aatcttttgc tgacagttga agaactgtta atgaaatact gttcattaaa aggatctgtg     6060

aaatca                                                                6066


<210> 780
<211> 1223
<212> DNA
<213> Homo sapiens

<400> 780
gttccttgga gagcttggag ccgcgcgccg gagggaatag gaaagcttgg ttacaacccg       60

ggacacccgg agcttcagga tggttcgtac taagacatgg accctgaaga agcactttgt      120

tggctatcct actaatagtg actttgagtt gaagacagct gagctcccac ccttaaaaaa      180

tggagaggtc ctgcttgaag ctttgttcct caccgtggat ccctacatga gagtggcagc      240

caaaagattg aaggaaggtg atacaatgat ggggcagcaa gtggccaaag ttgtggaaag      300

taaaaatgta gccctaccaa aaggaactat tgtactggct tctccaggct ggacaacgca      360

ctccatttct gatgggaaag atctggaaaa gctgctgaca gagtggccag acacaatacc      420

actgtctttg gctctgggga cagttggcat gccaggcctg actgcctact ttggcctact      480

tgaaatctgt ggtgtgaagg gtggagaaac agtgatggtt aatgcagcag ctggagctgt      540

gggctcagtc gtggggcaga ttgcaaagct caagggctgc aaagttgttg gagcagtagg      600

gtctgatgaa aaggttgcct accttcaaaa gcttggattt gatgtcgtct ttaactacaa      660

gacggtagag tctttggaag aaaccttgaa gaaagcgtct cctgatggtt atgattgtta      720

ttttgataat gtaggtggag agttttcaaa cactgttatc ggccagatga agaaatttgg      780

aaggattgcc atatgtggag ccatctctac atataacaga accggcccac ttcccccagg      840

cccaccccca gagattgtta tctatcagga gcttcgcatg gaagcttttg tcgtctaccg      900

ctggcaagga gatgcccgcc aaaaagctct gaaggacttg ctgaaatggg tcttagaggg      960

taaaatccag tacaaggaat atatcattga aggatttgaa aacatgccag ctgcatttat     1020

gggaatgctg aaaggagata atttggggaa gacaatagtg aaagcatgaa aaagaggaca     1080

catggaatct ggaggccatt tagatgatta gttaatttgt ttttcaccat ttagcaaaaa     1140

tgtatactac cttaaatgtc ttaagaaata gtactcataa tgagtttgag ctacttaata     1200

aaatacattt aagtggtatg taa                                             1223


<210> 781
<211> 3307
<212> DNA
<213> Homo sapiens

<400> 781
aaatttcccg ggccgggagc gctgggcctg ccgggaaggc gctgggacgg ttacccagcg       60

ggccgccggc ggtcgtgggc aagcttcgcc atgcagagca ctgacctagg caacaaggag      120

agcggcaaga tatggcaccg caagccgtcc ccggccacgc gggacggaat tatagtgaac      180

attattcaca acacttccga ttaccatcca aaagttttgc gatttttgaa tgtggctttt      240

gatggcacag gcgactgctt aattgctggg gaccaccaag gaaatattta tgtttttgac      300

ttacatggaa acaggttcaa tcttgttcag cgaacagcac aagcttgcac agctctggcc      360

tttaatcttc gtaggaaatc tgaattcctt gtggcattag ctgattattc tattaaatgt      420

tttgatacag tcaccaagga gctagttagc tggatgagag gacatgaatc atcagtattt      480

tcgatctctg tgcatgcatc agggaaatat gccatcacaa cttcttctga tacagcacaa      540

ttatgggact tggatacctt tcagagaaaa agaaagctga atattcgcca gtctgtgggt      600

atacagaagg ttttctttct accattaagt aataccatcc tcagctgttt taaagataat      660

tccatttttg cctgggaatg tgacacactt ttttgcaaat atcaattgcc agctccacct      720

gaaagctcta gtatattata caaagtgttt gctgtaacca gagatggccg aatcctggct      780

gctggaggca agtcaaatca tcttcatttg tggtgcttgg aagctaggca gctctttaga      840

attatccaga tgcccactaa agttcgagcc attcgccatc tggaatttct tcctgatagt      900

tttgatgctg gttctaatca ggttcttgga gtactaagtc aagatggtat tatgagattt      960

atcaatatgc agacttgtaa acttctcttt gagattggga gcctcgatga aggaattagc     1020

tcatcagcaa ttagcccaca tggacggtac attgcatcta ttatggaaaa tggaagtcta     1080

aacatatatt cagttcaggc tttaacacaa gaaataaata agccacctcc gcctttagtg     1140

aaagttattg aagatttgcc caagaataaa ctgagttcca gtgatcttaa gatgaaagta     1200

acatcaggga gagtacagca gccagcaaaa tctagggaaa gcaaaatgca aactagaata     1260

ttaaaacaag acctgactgg tgattttgaa agtaaaaaga atgaattacc agatggatta     1320

aacaaaaagc gtttacaaat cttattaaaa ggctatggtg aatatccaac aaaatacaga     1380

atgttcattt ggcgctctct gctacaactg cctgaaaatc atactgcgtt tagtaccctc     1440

atagataagg ggactcatgt ggcatttctc aaccttcaga agaaataccc catcaaaagt     1500

aggaagctac tcagagtatt acagagaacc ttatctgcat tagctcactg gtctgtcatt     1560

tttagtgaca caccatatct tccactcttg gcatttccat ttgtaaaatt attccagaac     1620

aaccaactca tctgttttga agttattgct actctcataa tcaattggtg tcaacactgg     1680

tttgaatatt ttcctaatcc tcctatcaat attcttagca tgatagaaaa tgttttggca     1740

tttcatgaca aggaactgct gcaacacttc atagatcatg atataacctc ccagctatat     1800

gcatggcctc ttcttgaaac tgtgttctca gaagtgctga caagagagga gtggctgaaa     1860

ttgttcgata atatcttttc caaccatcct tccttccttc tgatgactgt tgtagcctac     1920

aacatatgtt ctagaacgcc tctgctcagc tgtaatctta aagatgactt tgagtttttt     1980

tttcaccatc ggaataacct ggatataaat gttgtgatta gacaagttta tcatctcatg     2040

gagaccacgc ctactgacat tcatccagac agcatgctta atgtttttgt tgcactgaca     2100

aaagggcagt atccagtatt taatcaatat ccaaagttta ttgtggacta tcaaacacag     2160

gaacgagaaa gaataaggaa tgatgaattg gattacttaa gagagaggca gacagttgaa     2220

gatatgcaag ctaaagtcga ccagcaaaga gttgaagatg aagcttggta ccagaaacag     2280

gagctgcttc gtaaagctga agaaacaaga agagaaatgc tcttacaaga ggaggagaaa     2340

atgatacaac aaagacagag gctagctgct gtgaaaagag agctgaaagt aaaggaaatg     2400

cacttacaag atgctgcaag aaggcgtttt ctgaagcttc agcaagatca acaggaaatg     2460

gaactaagaa gactggatga tgaaattggg agaaaggtat atatgagaga tcgagaaatt     2520

gctgccacag ccagagacct agaaatgaga cagctggaac tcgaatcaca aaagagactt     2580

tatgagaaga atcttactga aaatcaagaa gctcttgcaa aagaaatgcg agcagatgca     2640

gatgcctata gacgaaaagt ggatcttgaa gaacacatgt ttcataagct gatagaagca     2700

ggtgaaaccc agagccagaa aactcagaag tggaaggaag ctgaaggaaa agagttccgt     2760

ttgagatcag caaagaaagc ttctgctctt tcagatgcgt ctagaaagtg gtttttaaag     2820

caagagataa atgcggctgt agaacatgct gaaaatccat gtcataaaga agaacccagg     2880

ttccaaaatg aacaggactc aagctgtttg cctagaacct cacaattaaa tgactcttct     2940

gaaatggatc cctcaacaca gatttcttta aatagaagag cagtagaatg ggacaccacg     3000

ggacagaatc ttattaagaa agtgagaaat cttcgccaga gactcactgc ccgggctcgt     3060

cacagatgtc aaacccctca tcttttggct gcatagaatg catgtcacct tgagacggtc     3120

gagagagaga cctattttgc aatcagtgac attgattttt agattattta tttaaaattc     3180

ctataaagat cagccctttg tacagaaaaa tgtgtctata aaaattatgt gttatttaat     3240

tctgatactt tttggcttgt aaatggcttc ttgaactttt tacaataaaa atgttttaga     3300

aactgtt                                                               3307


<210> 782
<211> 6963
<212> DNA
<213> Homo sapiens

<400> 782
gagcgctacc cacttccgcc ccctccccct gccattggaa ctagctgagc cgaactagtt       60

gcggccaccg agcagccggc tctcggcacc tcctcctccg cctccctgtc tcctgttcca      120

ttcgcctttc ctcttctttc ctggcccacg ccgctccgag gcctcgcgac cgccgagcct      180

gcagcctgcc ccgcggccaa catgagcttc ttgtttggta gtcgctcttc taaaactttt      240

aaaccaaaga agaacattcc agagggttct caccagtatg agctcttaaa acacgcagaa      300

gccacacttg gcagtggcaa ccttcggatg gctgtcatgc ttcctgaagg ggaagatctc      360

aatgaatggg ttgcagttaa cactgtggat ttcttcaatc agatcaacat gctttatgga      420

actatcacag acttctgtac agaagagagt tgtccagtga tgtcagctgg cccaaaatat      480

gagtatcatt gggcagatgg aacgaacata aagaaaccta ttaagtgctc tgcaccaaag      540

tatattgatt acttgatgac ttgggttcag gaccagttgg atgatgagac gttatttcca      600

tcaaaaattg gtgtcccgtt cccaaagaat ttcatgtctg tggcaaaaac tatactcaaa      660

cgcctcttta gggtttatgc tcacatttat catcagcatt ttgaccctgt gatccagctt      720

caggaggaag cacatctaaa tacatctttc aagcacttta ttttttttgt ccaggaattc      780

aaccttattg atagaagaga acttgcacca ctccaagaac tgattgaaaa actcacctca      840

aaagacagat aaaaggatgc agagctgtgc aaattgttcc tcaaatgaag cagtgtggag      900

tgtattgggg attttgttat attttgtttt tatctggatt gtttttgtcc taggtttggg      960

ggcgggggct tgtttgggtt cctttttctt tattctgatt atgtgaaacc atattctatt     1020

gctaggggaa gccaagaacc attctctata cacttgataa gggtaaattt atcttagtgt     1080

ttttaaactt ggttttggtt acttgaggag ttttttaata atattgtgtg ctgcaagaaa     1140

gtgcttgttg attgaactgc cgatggattg gtttctgtgt ggtataaatt gtggcccatt     1200

tatgaagtcc ccaaaagagt tatgttttta agtgccttgg caggctcact tctgaggtgc     1260

aaaacataga tatagaactg aacagggctt gaaacaatat taggattact acccagggca     1320

cttactggtg catgttgtaa catatctatg ataaaagcca tagtttacct aaaatggtga     1380

tttccagcct ttactgcttt gaagaaacag aatttgtaaa ggtatgcatg tagaacataa     1440

aaaatatttc ttaattattt tttatattga tggtaatata ttacgttcaa caatgcttaa     1500

agctctacaa gcaggtcttt tcccacctct tgatatctgt gatactgaaa cttgaggatg     1560

ttgaaatgta ttacattttg gcttctttct acatgttaac tgcactgtag atgtaaaaat     1620

tcaggttata tataggattg ccatcttcag aggtgatgct gaactgtgag gtttcctagt     1680

aattgccaaa tgagccgtaa gtctgcagaa ttcccttcta ctttgaagag aaggggatag     1740

gaatgtatat ttggctgggg gcatggagat gttcgtatgt atgaggagtt agggatgggg     1800

agtcaagttc tagaaagttt tgtctgaaaa cctttgaata gaatggcatg aagattttaa     1860

tcaattactt ataaacaaag tcttagagac ttccttttag gaatcaactt ccatgagaag     1920

ttaaaaataa attattaatt ttaggtacag acattaaaca tggaatttaa ggactgttgg     1980

gggaaattga tcacttctta gcatttccat tcagtgaatg gagctgatgt ttgcctgtca     2040

ttttaagatg ataccatacc ttctttggtt attataggtc cagtttgaag cattctgact     2100

tctggttttt ccaccctgaa aggaaatgtt tttctttgca gcagtattag ataatgaaaa     2160

atgctaattc agtagttatt aacttctaaa ttttattcgc catgactttc tagtgaatta     2220

ttaccataaa taacaatttc agaaacttag tttttagaat aaatattaat ttttccactt     2280

cagttttatt ctagaaaata ccctttttag aaatccagtt ttagttttgt cattttcgat     2340

aaatctttct tcagttagaa atatatatcc ttccttcagt tgaaacatat acctttttca     2400

catctaggaa gaaatgcttg ctctgaaata gtatagatta aaaacactca gtagaaaaga     2460

atctaaaatt aaatgaattt gttttgccat taaagtagag cagtgataca atttaatgcc     2520

attacaatta tgttgactag aaactgcctt tttctccact tcatttctag caattattta     2580

ccaagtacca acagtagaag taacaggaaa gcctggcaga gttaaatatc ttggacattt     2640

attggtaaag cttatttata aactgcagtc agagctagtt aatttcctta aatctttttg     2700

tattcagata gataatatga atcattatgg gttgattcag aaataaaatt tgtgaggtga     2760

ttttgaatct tgtccatata ggaaaatgaa gcacagaatt actcagtctt ccatattgta     2820

tttgacttca tatcaatcta gtaaaaaagg agttgcaata gccaagtata gagagaatag     2880

tgaaaaatta atcttgccct ttcaagcctt atacagtagt acactgtact tgtttttagt     2940

agtaagacct actttcccac tatatgtaga tagtttgttt tcactgtgcc agaatctcag     3000

gtgcctgctt agagtatttc tttaatcaca gtcactggga agtaaggaga tgtatatatg     3060

tgtatatatg gtaacaaagc atagcagttc tctaggggag aggcctggca ttgcacatgg     3120

tgttacatgg ctacaagtaa ggaaaaaatc agaaagtgaa agaactgatg taataaaagg     3180

ttgatttggt tggttcccat gaaagttagt aagatgccct tttaaatata aggatcagtg     3240

ctttgttctg cagcagagtt tgctgataaa tgtctgttgg attctttttg gatttcttta     3300

attaatttgt aagtaaccaa gataattatt ttcccccttg ctctctatat taatacgtag     3360

ctataaagca acagttggtt ttcttatcct ttgataaaag catcccataa aatataaagt     3420

agtaagttaa catagtatta ttgtcacaca caatgctttt tttggttaaa tgttgatacg     3480

aagcaatgtt ttggaattac tttaattgat ggagtagtgg tggtagagag aaattaataa     3540

caaaaagagt gaaaatattt taattagcag tagatggtgc tactggcttt catttgctga     3600

cttgattatt ccctttctct taaaaaccat ggcattagac tgcactaaat taacaagcat     3660

gttagttgct ggtagaggtt ttggaggtta atttacctta aattggaaga cttttaattg     3720

cagtctcttt ctaccttccc tctgttagtc atttgtaaat tctaaatggt caccataaaa     3780

tgtattaggt aggagaagat acgttttatg tataatatat ctcagactga gttactgcct     3840

gtcttatcag gatggataaa acactacagt ctcttatcag gaaatagaga tgatgtggat     3900

atttatatat tacatatata accaccagac tccattttat atattagcat tttccttgct     3960

tatgggaaaa tagcaaaaca acatttcatt tatacttttg tttacccctc tctgagacag     4020

gttttgataa ccactgaaat ggtagaatat gtgagataca aatattgagt tgtagaactt     4080

tctttttaag gtgaataagt catgccttaa catccaaata agagttcatc ttcagagtgg     4140

ttcttttggg agcactgttt attccagcta tactgcaaaa gtataatgtt tttggaactg     4200

ttctagagca taccatgaaa agcagtttgt tattatgcag gaaaatcagt ttcatcattt     4260

tagttacact aaacactttt ggcagcttaa tatgaccttt ttaaattttt tttatttttt     4320

ttatttttat ttctttaaga tggagtcttg ctctgttgcc cgggctggag tacaatggca     4380

tgatctcagc tcactgcaac ctccacctcc tgggttcaag catttctcct gcctcagcct     4440

cccaagtagc tgggattaca ggcagcacca cacctggcta attttcatat ttttagtaga     4500

gatggggttt caacatattg gccaggctgg tctcaaactc ctgacctcaa gtgatccgcc     4560

ctccccagcc tcccaaagtg ctgggattac aggtgtgagc caccacagcc agccagtatg     4620

acctatctta atcatcagct caactgtaat ttaaatttgg ctgttctctg gagctaaacc     4680

attagggaag ttcaaaggaa tgtgccatga tttccgaatt tgcacaagag aatgttttaa     4740

gcattggtag cataattgaa taaaagaata gtttcctgat gtcactattt tgaagtggaa     4800

attatcactt ggatgtggag gttttacttt ttaaaaacat tcagcttaat taccttacct     4860

taattacctt agttagatat actaatggaa aaaaaccaag tcctttctct agaacttgtt     4920

ttctattttt gttccttttc atgaaaactt ctcaatttaa ttttaactac tgtaggatag     4980

tattgattga atggatacta tggaaaagtg gatccaatat ttaagataga agtagtttaa     5040

ggagacaaca gcctttactg ccattttttt ttaaatgttt tcactcagat gaacaatttg     5100

actttaataa aagactggag atttttgtac aaagaaatag gaataagttt catatactaa     5160

ttatgctgag ttttaagcct acatatcaca aaatatttag aattgtataa ccttttcata     5220

tatttataac ttttaatgtc tttttaaaag atgtgggacc aaaaatatat ttataatttg     5280

gaaatgtgac tgcataccaa taagaaaact taccttattt tgaaatttat ctgggatatt     5340

aaagaatcta ccaattctta aaaacacaga tttatacttt aagcttattt taaaattaaa     5400

gaatatatac caattcttag aaacacttta aggactactc ttaaataact taaatatcag     5460

agttttgttg taatattaaa atttaccgtg gaaatcactg ttgttcagct atcaccttaa     5520

ttgtgtatga tatgataaat gtttagcagt aaagctatct taagatttaa tggaaaagtt     5580

taatttgaag atgtaacaaa aattctgacc acagttgatt ctgaattttt aaggctttcc     5640

taataggctg atcacagaga ataatccatt ttgaaggtat aaaactgcac tgtatgtctg     5700

tcacttgtag ctgaactgat tcacattttg acaaaagaga gaaaatacaa aaatgagttt     5760

tgcaaatgta ataacttttt ctgcatatag aactaaataa ttgaaaaata tgggctatag     5820

ttctcaaagg tagatagtaa aatcactggc tttttccagc tgtatgtttt tccactgtgc     5880

gtgtacacac acactggaaa ataattaggc tgattttgca ggtcttcatt gttagagatt     5940

ctgaagtatt tactgtcaat tcataggttt cagtttattt aggaaattag tgtttgacag     6000

ctttttttaa attatttcac tgaagctgag attattagtg atacaaagtt aaaatttcaa     6060

tatttaattt ctctatatat tattaatatt aaattgtttt ttacttataa attcatgttc     6120

tcatctgatt taatattaaa tttgtatagg tgggcgtttc ttaccatttt gcacaagttt     6180

ttgtttttct gaaatactta attgtgcagg ttgtaaaaaa gattagtgca ttttcatttt     6240

aaggatgctt tgctccttaa attgttcgac agaaatgact ttttagggaa agtagttttt     6300

ttggagctac taacttgtat ttattattgt acatgcataa ccagggtggt gagggcacta     6360

atcttgtagg aaacacttac ttgatgtttt atttgaactt ttcctatagg tttaactttt     6420

actgcataga attaacacta ggaacagtgt catgaaatct gggttgaagg agaatacagt     6480

atatatgaga acacttaaag ttcaaataga aatcatttct gaagacaaaa gcagaggaat     6540

attgtcagtg ccaagtaatg gaagaataag ggcggcattt acactgtgca agtattgaga     6600

agagtgcata aagacaggga actactctca tggagacagt ttctctctta taatcaagta     6660

actagaaggg gaaaaatcat ctaagttatg aaatccaaca taggcgctat attacaaact     6720

gtgccggatt atgcaaattg tagttgttac tgatcaaagt ttaattgctt catttttgtt     6780

taaaaaggga tactgatgtc agaaaatctg taatatgttt tattcaaaag atgtaaataa     6840

tgtatacaga cttgtatgtg atgggatggg aaatatttaa attctaggtg tttttttttt     6900

tttaaagaag aaactcaatg tttataagaa aaaaatgaat aaatagttac gtttggccat     6960

gaa                                                                   6963


<210> 783
<211> 624
<212> DNA
<213> Homo sapiens

<400> 783
tagggggcgc ggcggggcgg ggcgcacctt tcggcgggcc tcgcggatgg cggcgcaggg       60

cgtagggcct gggccggggt cggcggcgcc cccggggctg gaggcggccc ggcagaagct      120

ggcgctgcgg cgcaagaagg tgctgagcac cgaggagatg gagctgtacg agctggctca      180

ggcggcgggc ggcggtatcg accccgacgt gttcaagatc ctggtggacc tgctgaagct      240

gaacgtggcc cccctcgccg tcttccagat gctcaagtcc atgtgtgccg ggcagaggct      300

agcgagcgag ccccaggacc ctgcggccgt gtctctgccc acgtcgagcg tgcccgagac      360

ccgagggaga gacaaaggca gcgctgccct cgggggagta ttggccctgg cggaacgcag      420

caaccacgag ggatccagcc agaggatgcc acgccagccc agcgctacca ggctgcccaa      480

ggggggcggg cctgggaaga gccctacgca gggcagcacc taggatgggg cagagacttg      540

tcacatcttt gtccccagca aaggctacat gttacctcct tcagttgata ataaaccttt      600

ctgagatgca gagggtccag gtca                                             624


<210> 784
<211> 1949
<212> DNA
<213> Homo sapiens

<400> 784
aagatggcga tggctgcggt agcagcggcg gcggctgttg cctggcccgg taccctgggg       60

acgggggccg agtagcgcct tccccgggcc ccgtgaaccg gctgcgggtc gcccttgggg      120

ggcagcggcc gcagcccccc acctgggccc tcggtccgcc ctcccggcgc gtccatgaac      180

tcagtgtcgc cggccgccgc gcagtaccgg agcagcagcc cggaggacgc gcgccgccgg      240

cccgaggccc gcaggccgcg gggtcccaga ggcccagacc ccaacggcct ggggccttcc      300

ggagccagcg gccccgctct tggctctccc ggggctggcc cgagtgagcc ggacgaagtg      360

gacaagttca aggccaagtt cctgacagcc tggaacaacg tcaagtacgg ttgggtggtt      420

aaaagccgga ccagctttag caagatctcc agcatccacc tctgtggccg ccgctaccgt      480

ttcgagggcg agggtgacat acagcgtttc cagcgggact ttgtgtcccg cctgtggctc      540

acataccgcc gggacttccc gccccttcct gggggctgcc tgacctcgga ctgtggctgg      600

gggtgcatgt tacgcagcgg ccagatgatg ctggcacagg gccttctgct gcatttcctg      660

cccagagact ggacatgggc cgagggcatg ggcctgggcc cccctgagct gtcagggtca      720

gcctctccca gccggtacca tgggcctgcc cgctggatgc ccccacgctg ggcccagggt      780

gcccctgagc tggagcagga acgccggcac cggcagattg tgtcctggtt cgccgaccac      840

ccccgggccc cctttggcct acaccggctg gtggagcttg ggcagagctc aggcaagaag      900

gcaggtgact ggtatgggcc atcgctagtg gcacacatcc tcaggaaagc cgtggagagc      960

tgctccgacg tcacccgcct ggtggtgtac gtttctcagg actgcacagt gtacaaggcg     1020

gatgtggcac gcctggtggc caggccagac cccacagccg agtggaagtc tgtggtcatc     1080

ctggtgcccg tgcgactggg tggcgagact ctcaaccccg tgtatgtgcc ctgcgtgaag     1140

gaactcctgc gttgcgagct gtgcctgggc atcatgggtg ggaaaccgcg acactcactg     1200

tacttcattg gctaccaaga tgacttcctg ctgtacctgg accctcacta ctgccagccc     1260

actgtggatg tcagccaggc cgacttcccc ctggagtcct tccactgcac ctcgccccgc     1320

aagatggcct ttgccaagat ggacccaagc tgtaccgtgg gcttctatgc tggagacagg     1380

aaggagtttg agacactctg ctcagagctg accagggtcc tcagctcctc ctcagccaca     1440

gagcggtacc ccatgttcac cctggccgag ggccatgctc aggaccacag cctggacgac     1500

ctctgctccc agctcgccca gcccacactc cggctccctc gcacagggcg gctcctcagg     1560

gccaaacgcc ccagctctga ggactttgtg tttttataaa gggaggggat gaggggaaag     1620

atacaacact atttattttt ttatttatgt catgtcgggt gtgggatctt gagctctggc     1680

agtgatgatg gtacttcctg ttgtcagccc ctcaagccca gctgcaacca gtctggggcc     1740

attcagccag ggacagagcc cacagagccc atacacctgt ctcccaccag cggggccctc     1800

ctggcagggt agggaaggag gaccccgggc acccccctca gggcctgact cacgtactgt     1860

agtttgcact ggacgcccgg gccctccctg tcccaaagcc cccttggggg aactgtggct     1920

gctgggggcc aataaagctg tgtaacttg                                       1949


<210> 785
<211> 1912
<212> DNA
<213> Homo sapiens

<400> 785
ccccgccttg tggcgtcacg gggacgccgg gggcgcgcgg gctgcagggc cgcgtaggtc       60

cccgccccca gagtctggct ttccgcggct gcccgcctcg cgcgtcttcc ctgcccgggt      120

ctcctcgctg tcgccgccgc tgccacacca tggccttcgt caccaggcag ttcatgcgtt      180

ccgtgtcctc ctcgtccacc gcctcggcct cggccaagaa gataatcgtc aagcacgtga      240

cggtcatcgg cggcgggctg atgggcgccg gcattgccca ggttgctgca gcaactggtc      300

acacagtagt gttggtagac cagacagagg acatcctggc aaaatccaaa aagggaattg      360

aggaaagcct taggaaagtg gcaaagaaga agtttgcaga aaaccttaag gccggcgatg      420

aatttgtgga gaagaccctg agcaccatag cgaccagcac ggatgcagcc tccgttgtcc      480

acagcacaga cttggtggtg gaagccatcg tggagaatct gaaggtgaaa aacgagctct      540

tcaaaaggct ggacaagttt gctgctgaac atacaatctt tgccagcaac acttcctcct      600

tgcagattac aagcatagct aatgccacca ccagacaaga ccgattcgct ggcctccatt      660

tcttcaaccc agtgcctgtc atgaaacttg tggaggtcat taaaacacca atgaccagcc      720

agaagacatt tgaatctttg gtagacttta gcaaagccct aggaaagcat cctgtttctt      780

gcaaggacac tcctgggttt attgtgaacc gcctcctggt tccatacctc atggaagcaa      840

tcaggctgta tgaacgaggt gacgcatcca aagaagacat tgacactgct atgaaattag      900

gagccggtta ccccatgggc ccatttgagc ttctagatta tgtcggactg gatactacga      960

agttcatcgt ggatgggtgg catgaaatgg atgcagagaa cccattacat cagcccagcc     1020

catccttaaa taagctggta gcagagaaca agttcggcaa gaagactgga gaaggatttt     1080

acaaatacaa gtgatgtgca gcttctccgg ctctgagaag aacacctgag agcgctttcc     1140

agccagtgcc ccgagtgcct gtgggaatgc tctttggtca gacattccct cacacagtac     1200

agtttaataa atgtgcattt tgattgtaat ctatcgaagt gattattaca ccagttacag     1260

cagtaataga ttctccatta agaaataatt ccctttttta gtctgttcat ttctgtgtat     1320

tttctaaaca gctttacacc cttggtgcct tggagcaaac atgttttttg aaccttgtca     1380

tttttgtgaa gaattgccta gattccttct ctcatcaacg ggaaagtact tcctctgaga     1440

gtgcgagtgc accatgctca ctgttgctgc gtgggagagt cacaagccac tggcaagcaa     1500

gtggtatagt ctgtgaagca ctgcagcgag cagcacctgg atcttgcctt tataagaaca     1560

ttttactacc tgcagctttg agtcttgccc tacattttgg gcatgacata agatgtgtct     1620

ttattcagct cgtcgtgaag atgctgctgc tgaatgggtc agcatatctc tgtttgcatg     1680

gtttgcagga ggtcggtttt catggtcatt cagttccaca gatctgaatg attactgtct     1740

gtctgtgtct tttttccatg agaaatcact gttgcaaatt gcctataaat tgactctact     1800

aaaataacaa tgtttcagtc tgaaaatttg aattgaaaaa aatgtataat ataaaattgt     1860

aatacactca aatgattata aaagtaaaag ttggtaattt aggcagaagc ta             1912


<210> 786
<211> 2337
<212> DNA
<213> Homo sapiens

<400> 786
cgagggagtc cagagccttg agcccggtgc tcctccctcg cgcagcggtg gctctgcggc       60

cgctggagta aacactgcct ttgttcccta gcgcctcgtc tttcgtcgcc ccgtgccctc      120

acgccgccgg gctctggccg gcccgccctc ggtccttgaa ccccatttcg gctcgtgccg      180

tgcggatgca gctgccgggc ctgggtttgg gcattgagcg ggaggaggag gaggagcggc      240

ggcgcctggg cggcatgcga tggggaactg ctgctggacg cagtgcttcg gactgcttcg      300

caaggaagcg gggcggctgc agcgagtagg cggcggcgga ggatccaagt attttagaac      360

atgctcaaga ggtgagcact taacaataga gtttgagaat ctagtagaaa gtgatgaagg      420

ggagagccca ggaagcagtc ataggcctct tactgaggaa gaaattgttg acctaagaga      480

aaggcattat gattccattg ccgaaaaaca aaaagatctt gataagaaaa ttcaaaaaga      540

gcaagaaagg cagagaattg tgcagcaata tcatccttcc aacaatggag aatatcaaag      600

ttcaggacca gaagatgact tcgaatcttg tttgagaaat atgaagtcac agtatgaagt      660

ttttcgaagt agtagactct catcagatgc tacagttttg acaccaaata cagaaagcag      720

ttgtgattta atgaccaaaa ctaaatcaac tagtggaaat gacgacagca catccttaga      780

tctagagtgg gaagatgaag aaggaatgaa tagaatgctt ccaatgagag aacgttccaa      840

aacagaggaa gacattctac gggcagcact taagtatagc aacaagaaga ctggaagtaa      900

tcctacatca gcctctgatg attccaatgg gctggagtgg gaaaatgatt ttgttagtgc      960

cgaaatggat gataatggaa attccgagta ttctggattt gtaaatcctg tattagaact     1020

gtctgattct ggcataaggc attctgacac agatcaacag actcgatagg gtaaaattgt     1080

gtgaccttgt ttatcagtta tgaccaaatg ttaaaaacca actagaatgt ataagtgatt     1140

gtgcttagcc tttttgtaag ggagatgtgt aagaaaccat gttgtaaatg cttattttat     1200

tacaaaggag tagggatgat aggatctgaa ttgatacaga attaagtgca atttcatcat     1260

ctgccttctg cttttcaaga ccaatttaat ggtcctgtca tgttactgat taaatttact     1320

ttgtcttgtc tttatagcat ttctgtttac tatggtagat ttccactttc aatttttaaa     1380

attaatttta ctttgaatga tttatgaagc ctatttcatt gtctaactat gaaaatatta     1440

agactttttt gttaattctc agccgatgtg aaggaagcat gaggagggat cgtcagattc     1500

agatttagaa tagtgttccc gtttccagca ttatttattt ctatgacttc tttggatttt     1560

attatctaat agtaagtaca gttgatgtgg gtagatgact ctaagaaatg ctgaagtatc     1620

ggcattacat gtgtttattt acatgtccta gtatgataat gttgattcaa tctgaacaaa     1680

agataatata aaaataaccc ttcagagttt ggacatttca agttggtaat aataaaaaat     1740

aatatttaag aagatatata tatatatata tttagttttt tccacttcat tttacatgcc     1800

actatattga ctttaattga tatacagtat taagttttta ggtgccatta tttttaaaaa     1860

attctatatt tccaatgaac gatgttagat tttacacaga acatattctc tgcatgattt     1920

cagaaaagaa aatctaaaaa ggtaatacgg gtatttcaaa taaaatcctt tctggtatga     1980

aaggctccat tgattttatt aagccttcct ttaccttgta gtacaaggtg ctttaatggg     2040

atagaactaa gcatatcaat atctataact gcattttgtg ctagacaatt actgttcttt     2100

tctctaaaat gtatatgtca atttacaagg ccagggatag aaaacactcc ataattgctt     2160

tccttgattt tgctgaggat ttggtatgat tttagtaagc aaactgtttt ttggtttttc     2220

cttaatgttt ttaatttttt ttcctcttgc aacaatgacg gtgcatgttc ttataaatat     2280

aggaaggtcc agatataaat agtaacctaa agttcttgct gtgcttaaaa aaaaaaa        2337


<210> 787
<211> 1619
<212> DNA
<213> Homo sapiens

<400> 787
attggccgag cgcggccgtt gggggtgagg ccgcgtcggg ggaggacaac aaagggccgc       60

gggcggcggg cagtggtgtc ccagtctccc ggtgcttccc tgaggctgag gcgcccggcc      120

tcccgcccgc cgcgctccag atgaagtgtg agcactgcac gcgcaaggaa tgtagtaaga      180

aaacaaaaac tgatgaccaa gagaatgtgt cagccgatgc accgagtcca gcccaggaaa      240

atggagagaa gggagaattc cacaagttgg ctgatgccaa gatatttttg agcgactgcc      300

tggcatgtga cagctgtatg actgcagagg aaggagtcca actttcccag caaaatgcca      360

aggacttctt ccgcgttctg aaccttaaca agaaatgtga tacctcaaag cacaaagtgc      420

tggtagtgtc tgtgtgtcct caatctttgc cttattttgc tgctaaattc aacctcagtg      480

taactgatgc atccagaaga ctctgtggtt tcctcaaaag tcttggggtg cactatgtat      540

ttgatacgac gatagctgcg gattttagta tcctggagag tcaaaaagaa ttcgtgcgtc      600

gctatcgcca gcacagtgag gaggaacgca ccctgcccat gctgacctct gcctgtcctg      660

gctgggtccg atacgccgag cgggtgctgg gtcgccccat cactgcccac ctctgcaccg      720

ccaagtcccc ccagcaggtc atgggctctt tggtgaagga ttatttcgcc agacagcaga      780

acctgtctcc agagaagatt ttccacgtca ttgtggcccc ttgttatgac aagaagctgg      840

aggctcttca ggaaagcctt ccccctgctt tgcatggctc ccggggcgct gactgcgtgt      900

taacatcagg tgaaattgct caaataatgg agcaaggtga cctctcagtg agagatgctg      960

ccgtcgacac tctgtttgga gacttgaagg aggacaaagt gacgcgtcat gatggagcca     1020

gctcagacgg gcacctggca cacatcttca gacatgcggc caaggagctg ttcaacgagg     1080

atgtggagga ggtcacttac cgagccctga gaaacaaaga cttccaagag gtcacccttg     1140

agaagaacgg agaggtggtg ttacgctttg ctgcagccta tggctttcga aacatccaga     1200

acatgatcct gaagcttaag aagggcaagt tcccattcca ctttgtggag gtcctcgcct     1260

gtgctggagg atgcttaaat ggcagaggcc aagcccagac tccagacgga catgcggata     1320

aggccctgct gcggcagatg gaaggcattt acgctgacat ccctgtgcgg cgtccggagt     1380

ccagtgcaca cgtgcaggag ctgtaccagg agtggctgga ggggatcaac tcccccaagg     1440

cccgagaggt gctgcatacc acgtaccaga gccaggagcg tggcacacac agcctggaca     1500

tcaagtggtg aagtcaggcc agggccttcc agctgctctt ggggccagag ccaagagcct     1560

ctcagtagag ggaggggctg ccctgagtgg agtattaaag acacttaaga aaaccgctc      1619


<210> 788
<211> 1038
<212> DNA
<213> Homo sapiens

<400> 788
taagtgtaca tgcttaggcc ttctgaagca gcatttgaag ctgcagtcct gaaaaccatg       60

caggccggaa gagtagataa agaaatattt atttgagatg gcacatgttt cttcagaaac      120

tcaagatgtt tcccccaaag atgaattaac tgcttcagaa gcctccacta ggtctccatt      180

gtgtgaacac accttccctg gggactcaga cttacggtca atgattgaag aacatgcttt      240

tcaggttttg tcacaaggat ccttgttaga aagtccaagt tacacagttt gtgtctctga      300

gccagataaa gatgatgatt ttctttctct gaactttccc aggaaacttt ggaaaatagt      360

ggaaagtgac caattcaagt ctatttcatg ggatgagaat ggaacttgca tagtgattaa      420

tgaagaactc ttcaagaaag aaattttgga aacaaaggct ccttacagaa tatttcaaac      480

tgatgctatc aaaagttttg ttcgacagct caacctttat ggatttagta aaattcaaca      540

gaattttcaa agatctgcct ttctagccac ctttctgtca gaagagaaag aatcgtctgt      600

cttaagcaag atacgcttca ccaaaatgaa actttccaga tcttcaactt atgaaaacag      660

gtatttatgt tgcaacttac atttaaaaga tgagtcgaat tactcataat ccttagaagt      720

tagcttgtcc gcatctgaaa attcactttt accttgaagt tcaatctgtc tctgggaaag      780

actagattgg aagaataaaa ttcaagaatg tgatgtttta gtaatggaaa agccaagagc      840

gtcaggtggc aaaagtcctt ctgttactca agaaaatgct ctgaaaaatt ccttttctct      900

tttttttttg taaagattaa ctccacctca ccaccacaat gaggtatttt tctcagcaat      960

tgacacctgt ttactcagtt actccctgta actatgttat gctgtgaagt aggcaataca     1020

gttgttaaag aagaataa                                                   1038


<210> 789
<211> 4326
<212> DNA
<213> Homo sapiens

<400> 789
ctgccaaccc gcgagcccgc atcatggatg tcgagctccc ctatttcgca ttgctagccc       60

tggaattcga gaccccagac gaggaccagg attcatgaaa tcagtcgcag gggccggggc      120

aggggcctct ggctcccgac actggccgag aggtgatgag tgaggttcga agaacggaag      180

atttaaaaag cagccggggc ctccgtattg aatgaaagac ccagtgcaaa gacatcacca      240

tgaacactag cattccttat cagcagaatc cttacaatcc acggggcagc tccaatgtca      300

tccagtgcta ccgctgtgga gacacctgca aaggggaagt ggtccgcgtg cacaacaacc      360

acttccacat cagatgcttc acctgtcaag tatgtggctg tggcctggcc cagtcaggct      420

tcttcttcaa gaaccaggag tacatctgca cccaggacta ccagcaactc tatggcaccc      480

gctgtgacag ctgccgggac ttcatcacag gcgaagtcat ctcggccctg ggccgcactt      540

accaccccaa gtgcttcgtg tgcagcttgt gcaggaagcc tttccccatt ggagacaagg      600

tgaccttcag cggtaaagaa tgtgtgtgcc aaacgtgctc ccagtccatg gccagcagta      660

agcccatcaa gattcgtgga ccaagccact gtgccgggtg caaggaggag atcaagcacg      720

gccagtcact cctggctctg gacaagcagt ggcacgtcag ctgcttcaag tgccagacct      780

gcagcgtcat cctcaccggg gagtatatca gcaaggatgg tgttccatac tgtgagtccg      840

actaccatgc ccagtttggc attaaatgtg agacttgtga ccgatacatc agtggcagag      900

tcttggaggc aggagggaag cactaccacc caacctgtgc caggtgtgta cgctgccacc      960

agatgttcac cgaaggagag gaaatgtacc tcacaggttc cgaggtttgg caccccatct     1020

gcaaacaggc agcccgggca gagaagaagt taaagcatag acggacatct gaaacctcca     1080

tctcaccccc tggatccagc attgggtcac ccaaccgagt catctgcgct aaagtggata     1140

atgagatcct taattacaaa gacctggcgg ctctccccaa ggttaagtct atctacgagg     1200

tacaacgccc cgacctcatt tcctatgagc ctcattccag atacatgtcc gacgagatgc     1260

tggagagatg tggctatgga gagtcgctgg gaacattatc tccctactcc caggacatct     1320

acgagaacct ggacctccgg cagagacggg cctccagccc ggggtacata gactccccca     1380

cctacagccg gcagggcatg tcccccacct tctcccgctc acctcaccac tactaccgct     1440

ctgggcccga gagtggccgg agctctccat accatagcca gttagatgtg aggtcctcca     1500

ctccaacctc ttaccaggct cccaagcact ttcacatccc agctggagac agtaacatct     1560

accggaaacc cccgatctac aaacggcatg gtgatttgtc tacagcaacc aagagcaaaa     1620

caagtgaaga catcagccag acctccaagt acagtcccat ctactcgcca gacccctact     1680

atgcttcgga gtctgagtac tggacctacc atgggtcccc caaagtgccc cgagccagaa     1740

ggttctcgtc tggaggagag gaggatgatt ttgaccgcag catgcacaag ctccaaagtg     1800

gaattggccg gctgattctg aaggaagaaa tgaaggcccg gtcgagctcc tatgcagatc     1860

cctggacccc tccccggagc tccaccagca gccgggaagc cctgcacaca gctggctatg     1920

agatgtccct caatggctcc cctcggtcgc actacctggc tgacagtgat cctctcatct     1980

ccaaatctgc ctccctgcct gcctaccgaa gaaatgggct gcacaggaca cccagcgcag     2040

acctcttcca ctacgacagc atgaacgcag tcaactgggg catgcgagag tacaagatct     2100

acccttatga actgctgctg gtgactacaa gaggaagaaa ccgactgccc aaggatgtag     2160

acaggacccg tttagagcgc cacctgtccc aggaagagtt ctaccaagtc tttggcatga     2220

ccatctctga gtttgaccgg ctggccctct ggaagaggaa tgaactgaag aagcaagccc     2280

ggctgttcta ggcagaggct ctataaatat atatgcattt atataaagat atatgtaaaa     2340

tctctctact gaagctcggt ataatcctct cttgtgtaat gggacacact gcctgccatg     2400

agacttgctt ttctgtactg tcaggcaagc ccacgtcatc gagatatttt tatgctcctt     2460

actttctctt ttctaagtgc tgtgggatct gggaagggat ttgaggggac tctgtccttt     2520

tattggggat cctttttata ctgaaacatc tgtcctaact tgagtgcccc aaggtccaac     2580

tctctttcct aaagaaggtg cctgaagaag tctctcttct ctctgcttcg tggccccttt     2640

cttaaatttc tagggctgat gctgaccatg tggtttccac accttattgg ccccagaggg     2700

gccctcccat gggaagatct gcagcagtct ccccaaatca gtgagcacct ttgagcgccc     2760

acgaagaact ttctcaacac ccccaattag gagctcagtg ctctcttggg gcaatgcagt     2820

taaaagggtg agcctcaaat ctagtcatta caccagtcaa cagaagtgga cagggcctag     2880

gcctctcctc agctccttaa ccctcctcct tctgccctgg attgtaacct ctcccttgtc     2940

caaatctagg attcctggta ggaaaaggaa aaggcccttc ccttccctcc accacttcca     3000

actggcccct ttgcctgacc tggacttgga gaaccagagg aaaagagagg gagcggaagt     3060

gggagatgga gcagggcacc tgttagaatc agagctgcag gatttcttgg gaccctcctc     3120

tctccctcac tgctcccagc acctcctgac ccttccctct ttcaaggaga agcccatgat     3180

tgcagcttgt attctttagc cttattacaa tctatgtgcc tgacaactca acacaccgca     3240

gggctaatgt tcccaccaga gctccaactg aacaaccaga cagacaactc tcatcatcct     3300

ccagagagaa aataggccgt gtctcaaaga aaggttcttg gtctatgcct ctggtctgtg     3360

ggctggcagg gcaaccatac catacccccg ccagtcctcg gctcctgctg caaagttggc     3420

catgtttcac agggaaactt ttggaagagt ggctgcttat gagattccaa aatgaagtgt     3480

tggccaacac cgctcatggc catcctggat tttcccagtg gcttcccttc ctgctcgcct     3540

ccctgaacag gggagaaagc ttaacctctc ttctcctctc caaacctttc accttgaatg     3600

ggtaatgttt ggtgggggct gttccttctt ggagaagcct tgagtcggac cattttgaga     3660

tcatggagga aggatgaaga agtgaaaatg acaataatga ctctcaagag gctggcgatg     3720

tgacatggca aatgtagaac tgacttaaat tgaacaaacc ctcactgagc acctctgatg     3780

ttgagcacct gctgaatact gagcactgaa tgggggaggg ggaggggagc acggggtgag     3840

tcaacctggg actcggtctc agggatatgc ctaccaatag cgggtatcgt aaggcatgta     3900

cccaaacata acggatgtaa ggcagaaagt gatcggagaa ggaatgagaa agtgtgcgtg     3960

atgttaatga aaagtcatat gcagctagag cagacccagg aaagctttct ggaagagatt     4020

gcatctgagg aaattcagga aggatctttg tagattgggg ggagattcta aattgaaggg     4080

gtgatggggt gaggggccag agggaagtct gctgtgttct catgtaggat gtcagccctc     4140

cctgcaactt ctctttttgg ccaatgtctt ttcactttcc tgacccttta gaatcatccc     4200

cagccagacg caatcatgga agttgcctta ttgtcactgg ttaagaactt ggcgagattg     4260

aagggctttt gttattgttg ttggatattt ttgtttccca taaaagcaca tcatttcaac     4320

cctaaa                                                                4326


<210> 790
<211> 5714
<212> DNA
<213> Homo sapiens

<400> 790
agctgattct atcacattgt aagatgcctt tggataattc tacagtcctc ttaaatgaat       60

ctttagaact tggcaagtct cactagatac cttcaatcat cattttgagc tcaaagaatt      120

ctgagactta tggttggtca tatagaagag taccttgaac ctatagtttc ctgaagaatc      180

agtttaaaag atccaaggag tacaaaagga gaagtacaaa tgtctactac aagacgaaaa      240

cgtagtatgt tatgttgttt accgtaagct gtagtaaaat gagctcgatt gttgacagag      300

atgacagtag tatttttgat gggttggtgg aagaagatga caaggacaaa gcgaaaagag      360

tatctagaaa caaatctgaa aagaaacgta gagatcaatt taatgttctc attaaagaac      420

tgggatccat gcttcctggt aatgctagaa agatggacaa atctactgtt ctgcagaaaa      480

gcattgattt tttacgaaaa cataaagaaa tcactgcaca gtcagatgct agtgaaattc      540

gacaggactg gaaacctaca ttccttagta atgaagagtt tacacaatta atgttagagg      600

ctcttgatgg ttttttttta gcaatcatga cagatggaag cataatatat gtgtctgaga      660

gtgtaacttc attacttgaa catttaccat ctgatcttgt ggatcaaagt atatttaatt      720

ttatcccaga aggggaacat tcagaggttt ataaaatact ctctactcat ctgctggaaa      780

gtgattcatt aaccccagaa tatttaaaat caaaaaatca gttagaattc tgttgtcaca      840

tgctgcgagg aacaatagac ccaaaggagc catctaccta tgaatatgta aaatttatag      900

gaaatttcaa atctttaaac agtgtatcct cttcagcaca caatggtttt gaaggaacta      960

tacaacgcac acataggcca tcttatgaag atagagtttg ttttgtagct actgtcaggt     1020

tagctacacc tcagttcatc aaggaaatgt gcactgttga agaacccaat gaagagttta     1080

catctagaca tagtttagaa tggaagtttc tgtttctaga tcacagggca ccacccataa     1140

tagggtattt gccatttgaa gttctgggaa catcaggcta tgattactat catgtggatg     1200

acctagaaaa tttggcaaaa tgtcatgagc acttaatgca atatgggaaa ggcaaatcat     1260

gttattatag gttcctgact aaggggcaac agtggatttg gcttcagact cattattata     1320

tcacttacca tcagtggaat tcaaggccag agtttattgt ttgtactcac actgtagtaa     1380

gttatgcaga agttagggct gaaagacgac gagaacttgg cattgaagag tctcttcctg     1440

agacagctgc tgacaaaagc caagattctg ggtcagataa tcgtataaac acagtcagtc     1500

tcaaggaagc attggaaagg tttgatcaca gcccaacccc ttctgcctct tctcggagtt     1560

caagaaaatc atctcacacg gccgtctcag acccttcctc aacaccaacc aagatcccga     1620

cggatacgag cactccaccc aggcagcatt taccagctca tgagaagatg gtgcaaagaa     1680

ggtcatcatt tagtagtcag tccataaatt cccagtctgt tggttcatca ttaacacagc     1740

cagtgatgtc tcaagctaca aatttaccaa ttccacaagg catgtcccag tttcagtttt     1800

cagctcaatt aggagccatg caacatctga aagaccaatt ggaacaacgg acacgcatga     1860

tagaagcaaa tattcatcgg caacaagaag aactaagaaa aattcaagaa caacttcaga     1920

tggtccatgg tcaggggctg cagatgtttt tgcaacaatc aaatcctggg ttgaattttg     1980

gttccgttca actttcttct ggaaattcat ctaatatcca gcaacttgca cctataaata     2040

tgcaaggcca agttgttcct actaaccaga ttcaaagtgg aatgaatact ggacacattg     2100

gcacaactca gcacatgata caacaacaga ctttacagag tacatcaact cagagtcaac     2160

aaaatgtact gagtgggcac agtcagcaaa catctctacc cagtcagaca cagagcactc     2220

ttacagcccc actgtataac actatggtga tttctcagcc tgcagccgga agcatggtcc     2280

agattccatc tagtatgcca caaaacagca cccagagtgc tgcagtaact acattcactc     2340

aggacaggca gataagattt tctcaaggtc aacaacttgt gaccaaatta gtgactgctc     2400

ctgtagcttg tggggcagtc atggtaccta gtactatgct tatgggccag gtggtgactg     2460

catatcctac ttttgctaca caacagcaac agtcacagac attgtcagta acgcagcagc     2520

agcagcagca gagctcccag gagcagcagc tcacttcagt tcagcaacca tctcaggctc     2580

agctgaccca gccaccgcaa caatttttac agacttctag gttgctccat gggaatccct     2640

caactcaact cattctctct gctgcatttc ctctacaaca gagcaccttc cctcagtcac     2700

atcaccagca acatcagtct cagcaacagc agcaactcag ccggcacagg actgacagct     2760

tgcccgaccc ttccaaggtt caaccacagt agcacacgtg cttcctctct tgacatcaag     2820

ggaggaaggg gatggcccat taagagttac tcagatgacc tgaggaaagg agggaaagtt     2880

ccagcagttt catgagatgc agtattgagt gttctagttc ctggaattag ttggcagaga     2940

aaatgctgcc tagtgctaca gatgtacatt aaataccagc cagcaggagg tgatcatagg     3000

ggcatagcca gttctgacag tgttttaggt gcctggatat tttttgatgg aaaaagaata     3060

tattgccaaa tattaagaag ctcagctatg aaatgacctc cagggaatca gaaaggcact     3120

aatgatgtta gtaactttta gtggttctgt gcctcttatc aagtgttaca gaggacatac     3180

cactgccatg tcaggggttt gcttacagtg atgccatgaa gacagtccag tagacttggt     3240

agcgaccccc tcccccaacc cctctccctt ttcagataat gatggaacag taattacttt     3300

cagaatgttg tgtgggttca aattctctat gtacagatga tgtaaaaata tgtatatgtc     3360

tagataaaag gagagaaagc aaaacatttt gtatgctgca tgaaagcgtt atctcttcct     3420

tacaggtgtg agcacctttc ctgaaattct gacaccatgt gcaaactgat ccatcctgtt     3480

tttccttttg tttacaacac agtagtgttc tgttcacttt tccggggcac aagttttttt     3540

gttcatactt tggctgtgat gtcacagttt gttcagtgag gtatgatgtg ctgctgggaa     3600

tggatttttt ttttcaggtt aaattattga tacaacagga ttttcaagtt attcagaaat     3660

atccctcatt tcattatttt tcaattatgt ttgaaaatag gatttgcact gctttatttt     3720

aggtggctgg gagttttgat tgcatatttt gttatagttc atagttggaa atatttgcgt     3780

aaatggtttt caacaagcct gaaagtaatt tcaagaatgt ttcagttata gaggtaaaat     3840

ttgcacacaa aacatcttag gcacttttta acattctcaa tcatgggaat tttaactttt     3900

gggatttgtt gaaatctttt ttattatcct tcacaatttc aatgcttctt ttagtcagaa     3960

atgattcagg gttatttgag gggaaaaaac cccatagtgc cttgatttta attcaggtga     4020

taactcacca tcttgaagtc attgtccggt ttccgtagca gttttgaaac cttagtacct     4080

ttttaacagc atgtgggtgt cagtgtcatt attagtctcc taataagttc ctctgaagac     4140

tgctatcagt ctcttggact ggaggtacaa ataatttaga aataaaagat gataacctaa     4200

cactatcata gttattaatg tgatcctaaa attgtttcct aaatcagcat ttttctttag     4260

tcatttaaga atttaccaga aatatttgct caatatgatc ttgatattcc tacaaagaaa     4320

aaagaagggg tagggatttg gctatgcctt cactacaaca ttagaatatt gtaactcaca     4380

tgccttctaa acgtgaacta agatttcctt tggcaatatc atattctaaa agtaataaat     4440

tccaatacaa gttacataca tttaaaaaac attttacaga ttttatggta ctaatgaaat     4500

ttacagtgat agaacaaaag aggattagta gaaaatacat tattagaata taaaaaatgt     4560

tattactgag gaaagggagg agaggacaag tgtaataaat caaaattgac ctcaaaagaa     4620

aatgtgtaac agagttgagg ttgttaaaac agaaaaggtt ctgaataatg aagattaacc     4680

taatgcagaa ttgctaggta aagaggtcag gggaatgcta agccagttct taagacttct     4740

ctgtcctctg ctttgctgtt atccttaagg catatacttt gtctttctgc agaaaattct     4800

acctggctac aattactttg aacattaatg ttgaaaaaga aaacaaccaa agaaaattgg     4860

tacttaccct tctacaaaag aagtgtgact agatatcaat cagtaattaa catatcaagg     4920

agctcttcta gctaaatgac catccagtag agatttccca cattcccatg aatatcaaga     4980

atagttgtca gaatatgtat gtacctgagc atatgtacac agacaagggg gatgttgtgg     5040

aatatggcaa tagcattgtt cttctcccct ttcaaattgc ctttcttgac cttatgccat     5100

tccatatata tctgagttgt gcctcattta tttattggca atacctagtg atacggattt     5160

agctaacaaa agatatgaag aactattata ttgaggcctg tcctctacat accacactta     5220

aaagatggtg aactgtgagt actacttagg ttgacagcaa caaagcataa gacaagcccc     5280

aggtaaacgt ctaaactgtt tactcacatt gtcctactcc agccccttca attatttccc     5340

atctccacaa atagtcgggg gaaaaaatta aaattttcct ttatgattct tactgttctt     5400

cgcagctcat cttttcctgc ttagaattaa ccattgctaa tttaaaggag cagctagctg     5460

cttttctgtc agtctgaagc gtagtagtgg aagaggtagt aagcaccagc tgcctctttg     5520

ctgctttgtt ttcctcctga ttctcttaaa tttgggttgc aaagctatcc cgccccccac     5580

cctgccccat gaaacttgag cattcaaatg aagattcagc agtgtctgtt cttcatttct     5640

atagccaaag ctgttagtta aaatcccaaa tctatagcat ttaaagatac caaatagaaa     5700

caccttccag cttt                                                       5714


<210> 791
<211> 1815
<212> DNA
<213> Homo sapiens

<400> 791
taggattgac actggctgtc aaactcatcc ttcaaggtga ttcctggcct gccctcctcc       60

tccaggcagc ctgtcctcct cctccaggca gcctgtcctg accctcagca gcctctcctg      120

gccttggcag agcccctcgt gtcctccctt gcagcacgca tgggaagaaa ggccatcgtc      180

ctcgccattg ctaacaccag ccttgcgttt cctctttgcc agcacctggt gacgttctgc      240

ctgggtgagg acgatggcgt gcataccgtg gaggatgcct ccaggaagtt ggccgtcatg      300

gatagccagg gccgagtctg ggcacaggag atgctgctgc gagtgtctcc cgaccatgtc      360

acgctgctcg acccggcctc caaggaggag ctggagtcgt acccactggg cgccatcgtg      420

cgctgtgacg cggtgatgcc acccggcagg agccgctcgt tgctgctgct cgtgtgccag      480

gaacccgagc gcgcgcagcc cgacgtgcac ttcttccagg gcctgcgcct cggggcggag      540

ctgatccgag aggacatcca gggggctctg cacaattacc gctcgggccg cggggagcgc      600

agggcggcgg cgctcagggc cacgcaggag gagttgcagc gcgaccgctc gcccgccgct      660

gagaccccgc ccctgcagcg ccgcccgtca gtccgcgcag tgatcagcac cgtagagcgg      720

ggcgcgggcc gcggacgacc ccaggcgaag cccattcccg aggcagagga ggcgcagagg      780

cctgagccgg tggggacctc gagcaacgct gactcggcct ccccggacct gggtccccgg      840

ggtcctgacc tggcggttct gcaggcggag cgggaagtgg acatcctgaa ccacgtgttc      900

gacgacgtag agagctttgt atcgaggctg cagaagtcgg cggaggcggc cagggtgctg      960

gagcaccggg aacgcggccg caggagccgg cgccgggcgg ctggggaggg cttgctgacg     1020

ctgcgggcca agccgccctc ggaggccgag tacaccgacg tgctgcagaa gatcaagtac     1080

gccttcagcc tgctggcccg gctgcgcggc aacatcgccg acccctcctc tccggagctg     1140

ttgcacttcc ttttcgggcc tctgcagatg attgtgaaca cgtcgggggg gccggagttc     1200

gcgagcagtg tgcggcggcc gcatctgaca tcggatgccg tggcgctgct gcgggacaac     1260

gtcactccac gtgaaaacga gctctggacc tcgctggggg actcgtggac ccgccccggg     1320

ctggagctgt ccccggagga gggaccccca tacagacccg agttcttcag cggctgggag     1380

ccgccggtca ctgacccgca gagccgcgcc tgggaggacc cagttgagaa acagctacag     1440

cacgagcgga ggcgccggca ggtgacccaa gcgacacagc agggccgagg ctgggaagtc     1500

cgggggcgcg gccggtccgc ctggccccgc ctgacccgac tgtcttactt cctacagcaa     1560

agcgcccccc aggtcgctgt caatggtcac cgagacttgg agccagaatc tgagcctcag     1620

ctggagtcag agacagcagg aaaatgggtc ctgtgtaatt atgacttcca ggcccgcaac     1680

agcagtgagc tgtcggtcaa gcagcgggac gtactggagg ccctccagga caaagagaaa     1740

gtgtcagagc tggaggcagt gatggagaag caaaagaaga aggtggaagg cgaggtggaa     1800

atggaggtca tttga                                                      1815


<210> 792
<211> 4122
<212> DNA
<213> Homo sapiens

<400> 792
aggagaagtc gggaaggtgg cggcggcggc ggcggttgtc ccggctgtgc cggttggtgt       60

ggcccgtcag cccgcgtacc acagcgcccg ggccgcgtcg agcccagtac agccaagccg      120

ctgcggccgg gtccggcgcg ggcggcgcgc gcagacggag ggcggcggcc gcggccaggg      180

cggcccgtgg gaccgcgggc ccccggcgca gcgctgcccg gctcccggcc ctgccggcct      240

cctcccttgg cgccgcggcc atggcggcca gcgcgaagcg gaagcaggag gagaagcacc      300

tgaagatgct gcgggacatg accggcctcc cgcacaaccg aaagtgcttc gactgcgacc      360

agcgcggccc cacctacgtt aacatgacgg tcggctcctt cgtgtgtacc tcctgctccg      420

gcagcctgcg aggattaaat ccaccacaca gggtgaaatc tatctccatg acaacattca      480

cacaacagga aattgaattc ttacaaaaac atggaaatga agtctgtaaa cagatttggc      540

taggattatt tgatgataga tcttcagcaa ttccagactt cagggatcca caaaaagtga      600

aagagtttct acaagaaaag tatgaaaaga aaagatggta tgtcccgcca gaacaagcca      660

aagtcgtggc atcagttcat gcatctattt cagggtcctc tgccagtagc acaagcagca      720

cacctgaggt caaaccactg aaatctcttt taggggattc tgcaccaaca ctgcacttaa      780

ataagggcac acctagtcag tccccagttg taggtcgttc tcaagggcag cagcaggaga      840

agaagcaatt tgacctttta agtgatctcg gctcagacat ctttgctgct ccagctcctc      900

agtcaacagc tacagccaat tttgctaact ttgcacattt caacagtcat gcagctcaga      960

attctgcaaa tgcagatttt gcaaactttg atgcatttgg acagtctagt ggttcgagta     1020

attttggagg tttccccaca gcaagtcact ctccttttca gccccaaact acaggtggaa     1080

gtgctgcatc agtaaatgct aattttgctc attttgataa cttccccaaa tcctccagtg     1140

ctgattttgg aaccttcaat acttcccaga gtcatcaaac agcatcagct gttagtaaag     1200

tttcaacgaa caaagctggt ttacagactg cagacaaata tgcagcactt gctaatttag     1260

acaatatctt cagtgccggg caaggtggtg atcagggaag tggctttggg accacaggta     1320

aagctcctgt tggttctgtg gtttcagttc ccagtcagtc aagtgcatct tcagacaagt     1380

atgcagctct ggcagaacta gacagcgttt tcagttctgc agccacctcc agtaatgcgt     1440

atacttccac aagtaatgct agcagcaatg tttttggaac agtgccagtg gttgcttctg     1500

cacagacaca gcctgcttca tcaagtgtgc ctgctccatt tggagctacg ccttccacaa     1560

atccatttgt tgctgctgct ggtccttctg tggcatcttc tacaaaccca tttcagacca     1620

atgccagagg agcaacagcg gcaacctttg gcactgcatc catgagcatg cccacaggat     1680

tcggcactcc tgctccctac agtcttccca ccagctttag tggcagcttt cagcagcctg     1740

cctttccagc ccaagcagct ttccctcaac agacagcttt ttctcaacag cccaatggtg     1800

caggttttgc agcatttgga caaacaaagc cagtagtaac cccttttggt caagttgcag     1860

ctgctggagt atctagtaat ccttttatga ctggtgcacc aacaggacaa tttccaacag     1920

gaagctcatc aaccaatcct ttcttatagc cttatataga caatttactg gaacgaactt     1980

ttatgtggtc acattacatc tctccacctc ttgcactgtt gtcttgtttc actgatctta     2040

gctttaaaca caagagaagt ctttaaaaag cctgcattgt gtattaaaca ccaggtaata     2100

tgtgcaaaac cgagggctcc agtaacacct tctaacctgt gaattggcag aaaagggtag     2160

cggtatcatg tatattaaaa ttggctaata ttaagttatt gcagatacca cattcattat     2220

gctgcagtac tgtacatatt tttcttagaa attagctatt tgtgcatatc agtatttgta     2280

actttaacac attgttatgt gagaaatgtt actggggaaa tagatcagcc acttttaagg     2340

tgctgtcata tatcttggaa tgaatgacct aaaatcattt taaccattgc tactggaaag     2400

taacagagtc aaaattggaa ggttttattc attcttgaat ttttcctttc taaagagctc     2460

ttctatttat acatgcctaa attcttttaa aatgtagagg gatacctgtc tgcataataa     2520

agctgatcat gttttgctac agtttgcagg tgaaaaaaaa taaatattat aaaatatgct     2580

attgtttttg tgttcttgct gcaatgcctt taccaaagtg gccttaaata tgagtagtga     2640

attgagaaca tcttgaattc ttaaaagact tcttagtgac tttttataaa aaggccatgt     2700

agaaaattta ttaaaactac tatgactgct acattcagga atatgccagt ggtaaagcat     2760

ttaaatgtag cttgtcagat ttaccataat cctactaatt tctttgcagc ttattaattt     2820

tgtgaaattt gtatatatga agaatttgca tgtatgtgta tttacaaatt tttctaagta     2880

tcttgaattc tcagactgca aaaggcctat tttaactatt gatttttttt aaaaaaaatt     2940

gtctttgaat gtattggaag tagacatgca ttaactgtga cattattgca cctcagtttt     3000

tttctttctt tttttgggca aactgatatt atctatagga tatttgttta tgtttgtttt     3060

ttgggggaaa gaaactggaa ctcagtgtta ccttaaagtt acggaatact ttgttttaaa     3120

ggaaaagata ataagtttag ttatatcttt ttgttaatat tcaaatgaac ttgtttaagt     3180

atctatgtac agtaatgcct cattcatcta gaggtaatct ggcagtcttg tgaaaaccga     3240

acacaactca gaaacttgga atcgtttttt ttaaaaatgc ctctgagcaa cccatataag     3300

tcacaaagtc tgtgtgttag agcttatgca tttgttttta tgagagattt taataaattt     3360

aattatttgc ttgtccagac tatagcatat tagctgttta gaagggatgg cttgaaagga     3420

aggagactga aaaacactct gagagcatac actgtccaag gccattagtg taaggaccgc     3480

tacccagcct agaggacatc actatactac atcatctgat gattattctt tattatgcct     3540

ctaggtaatt aagtaaaggt gaaattgcat acacagatat gtagtacata ttttaaaagt     3600

tttatcttaa attgattaaa actttttaaa aagctttggt attaaaagag gtaaacatca     3660

gtttcctcaa acattttatt catgttgaat gcctttttgc aatgatgact gagttgttat     3720

catagtattt taaaacctgt atagtgtttt agacttgtta aaacattgct gtctagtgta     3780

catctagcta aaagtgtggt ttatctaaac cgttttaata agcaagatga ctgggaaatc     3840

tctgcccctt ttctgagcag tatgcctctt cttttagaat taaatgaatg ctgcacaggt     3900

ccagatgtgt gttgatgtag acttgaaatg tctccacatt ttggaggact tcctcagccc     3960

ttttcattga gggaaaatat atttgaattt ctgttttaga ttgtatcggg tcccagttga     4020

ttcatgtgta caaagttatg ctacctaatt acagaccatt acccaaatat cctaccaggc     4080

tttccatctg aatagtaaat taaacagttg ttatcaaaat ga                        4122


<210> 793
<211> 2552
<212> DNA
<213> Homo sapiens

<400> 793
gaaggaggga cggccggtcc cgtcagtcag gcagcgggag ccgccgggag cggatggcgg       60

cggccgtagc ggctccactc gccgccgggg gtgaggaggc ggcagccacg acctccgtgc      120

ccgggtctcc aggtctgccg gggagacgca gtgcagagcg ggccctagag gaggccgtgg      180

ccaccgggac cctgaacctg tctaaccggc gcttgaagca cttcccccgg ggcgcggccc      240

gtagctacga cctgtcagac atcacccagg ctgacctgtc ccggaaccgg tttcccgagg      300

tgcccgaggc ggcgtgccag ctggtgtccc tggagggcct gagcctctac cacaattgcc      360

tgagatgcct gaacccagcc ttggggaatc tcacagccct cacctacctc aacctcagcc      420

gaaaccagct gtcgctgctg ccaccctaca tctgccagct gcccctgagg gtcctcatcg      480

tcagcaacaa caagctggga gccctgcccc ctgacatcgg caccctggga agcctgcgac      540

agcttgacgt gagcagcaac gagctccaat ccctgccctc ggaactgtgt ggcctctctt      600

ccctgcggga cctcaatgtc cggaggaacc agctcagtac gctgcccgaa gagctggggg      660

acctccctct ggtccgcctg gatttctcct gtaaccgcgt ctcccgaatc ccagtctcct      720

tctgccgcct gaggcacctg caggtcattc tgctggacag caaccctctg cagagtccac      780

ctgcccaggt ctgcctgaag gggaaacttc acatcttcaa gtatttgtcc acagaggccg      840

ggcagcgtgg gtcggccctg ggggacctgg ccccttctcg gcccccgagt ttcagtccct      900

gccctgcaga ggatctattt ccgggacatc ggtacgatgg tgggctggac tcaggcttcc      960

acagcgttga tagtggcagc aagaggtggt ctggaaatga gtcaacagat gaattttcag     1020

agctgtcatt ccggatctca gagctggccc gggagccccg gggacccaga gaacgcaagg     1080

aggatggctc agcggacgga gaccctgtgc agattgactt catcgacagc catgtccccg     1140

gggaggatga agagcgaggc actgtggagg agcagcgacc acccgaatta agccctgggg     1200

caggggacag ggagagggca ccaagcagca ggcgggagga gccggcaggg gaggagcggc     1260

ggcgcccgga caccttgcag ctgtggcagg agcgggaacg gcggcagcag cagcagagcg     1320

gggcgtgggg ggccccgagg aaggatagcc tcttgaagcc agggctcagg gctgttgtgg     1380

gaggggccgc cgccgtgtcc actcaagcca tgcacaacgg ctcgcctaag tccagtgcct     1440

cccaagcagg ggctgcagcg gggcagggag cccccgcccc tgcccctgcc tcccaagagc     1500

cccttcccat agctggacca gcgacagcac ctgctccacg gccacttggc tccattcaga     1560

gaccaaacag cttcctcttc cgttcctcct ctcagagtgg ctcaggccct tcctcaccag     1620

actctgtcct gagacctcgg cggtaccccc aggttccaga tgagaaggac ttaatgactc     1680

agctgcgcca ggtccttgag tcccggctgc agcggcccct gcctgaggac ctggccgagg     1740

ctctggccag tggggtcatc ctgtgccagc tggccaacca gctacggccg cgctccgtgc     1800

ccttcatcca tgtgccctcc cctgctgtgc caaaactcag tgccctcaag gctcggaaga     1860

atgtggagag ttttctagaa gcctgtcgaa aaatgggggt gcctgaggct gacctgtgct     1920

cgccctcgga tctcctccag ggcactgccc gggggctgcg gaccgcgctg gaggccgtga     1980

agcgggtggg gggcaaggcc ctaccgcccc tctggccccc ctctggtctg ggcggcttcg     2040

tcgtcttcta cgtggtcctc atgctgctgc tctatgtcac ctacactcgg ctcctgggtt     2100

cctaggcccc aaaatcggcc ctccctcacc cctttccctt cctctctatt tataaggtcc     2160

ctgctccacc cgaccccacc tgcggtgcct tcagccccaa ccaaagacac tagtgcaccc     2220

ccttcacaga cactgacctc agaggcccca ctctggtgcc cccagaccct gggcccccag     2280

cctctggcct ccctccagta gccccacgag tccccacctc tcagtgctga cggtgccttc     2340

atgtccccgc cggccctgcc cctgccctct gtaccccgtg aggggtggca ggagctggag     2400

tctccccctt cctcctgtgc cctccccttc cccccccaac agctgctatg ggggggctaa     2460

attatctcta ttttgtagag aggatctata tttgtagggg ttcggggccc aggccgggtc     2520

cctatctctg tgtataaact gtacagaccg tg                                   2552


<210> 794
<211> 691
<212> DNA
<213> Homo sapiens

<400> 794
ccgcctcaga ctcagagctg cgctcctcga cctcaacgcc aggcggttac tttgctgctc       60

ctcccgctcg ctatgtcaac gtccactagc tgcccgattc ccgggggccg ggaccagctg      120

cccgactgct acagcaccac gccggggggc acgctatacg ccactacccc cggaggcacc      180

aggatcatct acgaccgaaa gttcctgctg gagtgcaaga actcacccat tgcccggaca      240

cccccctgct gcctccctca gattcccggg gtcacaactc ctccaacagc ccctctctcc      300

aagctggagg agctgaagga gcaggagaca gaggaagaga tacccgatga cgcacaattt      360

gaaatggaca tctaatccag tgcagatgac ctggcatgtg gagttacaga gggatccctc      420

atgccactgc tgccaccacc tcttcctggg gcatccaaag gccagctggc ctcatctaat      480

ctggaaggga gtgacttgtt agttccaggc ctcctttagt tctgaggcag ctagaccagg      540

gataggagtg ggcaacttgc caagccctta actctacttc ctcttcagtc tgtggtactc      600

ctcctaaccc taaaccctct atgctcaggg gctggaactg gggaatggag taagtcacct      660

tctgactgct tagtaaacat tcaaagaaat g                                     691


<210> 795
<211> 3708
<212> DNA
<213> Homo sapiens

<400> 795
atgcctatgg agtcagcatc ttcagataat aagaaacaga tacctaatga agcttctgct       60

agaagtgaaa gagacacatc agacctagag caaaactggt cattgcaaga tcattataga      120

atgtattcac ccataatata ccaagccctc tgtgagcacg tgcagactca gatgtcactg      180

atgaatgact tgacttcaaa gaacatccct aatggaattc ctgctgtacc atgccatgct      240

ccctctcatt ctgaatctca ggcaactcct cattctagtt atggcttatg tacctccacc      300

ccagtctggt cacttcagcg gccaccctgc cctccaaagg ttcattctga agttcaaact      360

gatggcaaca gtcagtttgc atcacaaggt aaaacagttt ctgcaacctg tactgatgtt      420

ctacggaatt catttaatac cagtcctgga gttccatgta gcctgcccaa aactgacata      480

tcagctattc caacattgca gcaactgggc cttgttaatg gaattctgcc acaacaagga      540

attcataagg aaacagacct actaaaatgt attcaaacat atttgtctct ttttcgatct      600

catggaaaag aaacgcatct ggacagtcag acacaccgaa gccctactca gtcacaacca      660

gctttcttgg ccactaatga agaaaaatgt gccagagagc aaattagaga ggccacaagt      720

gaaagaaagg atttaaacat acatgtgcga gatacaaaaa cagtgaagga tgtacagaag      780

gcaaaaaatg tgaacaagac agctgaaaaa gttagaatta taaaatattt gttgggagag      840

ctcaaggccc tggtagcaga acaagaggat tcagaaattc agaggttgat tacagaaatg      900

gaggcatgta tatctgtact tccaacagta agtggaaaca cagatattca agttgagata      960

gcactggcca tgcaaccatt aagaagtgag aatgctcagt tacgaaggca gttgagaatt     1020

ttgaaccagc aactcagaga acaacagaaa actcaaaaac catctggtgc tgtggattgc     1080

aaccttgaat tgttttctct tcagtcattg aatatgtcac tgcaaaatca attggaggag     1140

tcactaaaga gccaggaatt actgcagagt aaaaatgaag agctgttaaa agtgattgaa     1200

aatcagaaag atgaaaacaa aaaatttagt agtatattta aagacaaaga tcaaactata     1260

cttgaaaata aacagcaata tgatattgag ataacaagaa taaaaattga attggaggaa     1320

gccctagtca atgtgaaaag ctcccagttt aagttagaaa ctgctgaaaa ggaaaaccag     1380

atattgggga taacattacg tcagcgtgat gctgaggtga ctcgactaag agaattaacc     1440

agaactttac agactagcat ggcaaagctt ctctccgatc ttagtgtgga cagtgctcgc     1500

tgcaagcctg ggaataacct taccaaatca ctcttgaaca ttcatgataa acaacttcaa     1560

catgacccag ctcctgctca cacttccata atgagctatc taaataagtt agaaacaaat     1620

tacagtttta cacattcaga gccactttct acaattaaaa atgaggaaac catagagcca     1680

gacaaaacct atgaaaatgt tctgtcctcc agaggccctc aaaatagtaa cactaggggc     1740

atggaggaag catctgcacc tggaattatt tctgcccttt caaaacagga ttctgatgaa     1800

gggagtgaaa ctatggcttt aatagaagat gagcataatt tggataatac aatttacatt     1860

ccttttgcta gaagcactcc tgaaaagaaa tcaccacttt ctaagagact atcccctcag     1920

ccacaaataa gagcagctac aacacagcta gtcagcaaca gcggacttgc tgtctctgga     1980

aaagaaaata aactgtgtac acctgtaatc tgttcctctt caacaaagga agcagaagat     2040

gcacctgaaa aactttccag agcatctgat atgaaggaca cacagctcct caagaaaata     2100

aaggaagcaa ttggtaagat ccctgctgcc accaaggagc cagaggaaca aactgcatgt     2160

catggcccat caggttgtct tagcaacagc cttcaagtga aaggcaatac tgtctgtgat     2220

ggtagtgttt tcacttctga cttgatgtct gactggagca tctcttcgtt ttcaacgttc     2280

acttctcgtg atgaacaaga cttcagaaat ggccttgcgg cattagatgc caacatagct     2340

agactccaga agtctttaag gactggtctt ctggagaaat gaattcagaa gaaaactcat     2400

caggtgcttc tttttaaaac tagaacttgg ctatattgaa tgtgtatttt tctttagtga     2460

aatgatgttt tatgttatta tgtgtgaagt aatatattgt acaagtaata aatgtattgt     2520

tgagatatat tgacactgag gagcttataa aaacaagtca tcttaagttc acaattgcta     2580

caagaagaaa gttgtggata actaggaaat tattgtaagt aatgttttat ttcagtactt     2640

agcaattaga gttcttttat taagatgtat ctgctggatt aagggtacag gttgaaatag     2700

ttctgtggct gtcctaagaa ataatgggaa aagaatctct ggatgtaagt ttttctgttg     2760

aaactagagg gttttttttt tctgtttaca tatacttttt tttaatagca atgtgttttt     2820

attaaacatg ctgtgtgcca caggccagtg ttgttggtga aatatataaa catttattta     2880

aagagaaaag ttaccagtat ctacacctct taaaaaacat tgattggtct aaaaaatata     2940

tagataacat cctaagttaa catatggctt cttaaaactt gggcactttt atttgttttt     3000

atcccaaatt catgttttaa ggcctttaaa gaatagtcag actgataaag aagtgctaac     3060

agataagcta tagttgggga aatttgtggg ttttttttaa ataagaaatg tttatttttg     3120

tccttatatt taaacatgat ggaatttgta aatcttggca ttgattgtaa ttctgccttt     3180

ttggaagaat tttttctccc agcatgttag ctgagaatat tctctatttt ataaataata     3240

tgaagtaggt tggtctctct gcttctctat accaggactt cttagctcag tatcatctcc     3300

cttcatgtaa gcagcacgtt ttaactctta ggaagctgaa tgttgtgtta tcactaatac     3360

tttgtacagg tcacctgcct actctaattg tccttagtac ttggacaggc tttatcatta     3420

aagagtgttc tcctaatccc agaacctcct cgtgtttttt gtttttttgg tggttttttt     3480

ttttttttta ggtgttagtg ctacagcgtt tgaaggagcc agctgtagtc tctttgatat     3540

gttcagattt tccagataga gatttaagtc taaaaattta ttaagtgaat tctaaactat     3600

ttcacacaag agtccattag catctttaat tttatttagt attcatgaat taatttattg     3660

gcatcttatt tggaggtaat aggccacaac tctttaacaa ataagttc                  3708


<210> 796
<211> 1521
<212> DNA
<213> Homo sapiens

<400> 796
cgggtccctc aaggccggaa agaaagtcgg gcttctctag cccctggagg actcgactca       60

ctggtgcgcg atttaggtcc ggaggaggcg ttgtgaggtg agctttttca gaagcgcgat      120

cccaggacac gtcgggaagc aagcatcccc agagctgctt ggaaagagga ccaaagacgt      180

ctaaaaagtc atttggaaat atctctaaat atttgttacc atgtataagc tgctaaagag      240

aaattgggcc caacaaaact aattgaataa ttgaggcaga tttgtgtgta tcatcaaatt      300

ctatccagaa gttgaagaat ctgaatttaa agattgtgtg catttaataa gaggatgacc      360

tttcagttta atttcactat agaagaccat ctggaaaatg aattaacacc cattagagat      420

ggagctttga ccctggattc ctcaaaagag ctgtcagtct cagaaagtca aaaaggagaa      480

gagagggaca gaaaatgttc tgcagaacaa tttgacttgc ctcaggatca cttgtgggaa      540

cataagtcaa tggaaaatgc agctccctct caagacacag acagtccact cagtgcagcc      600

agcagttcaa ggaacttgga gccacatgga aaacagccct ccttgagagc tgccaaagag      660

catgctatgc ctaaagattt aaagaagatg ttagaaaata aagtcataga aacattacca      720

ggtttccagc atgttaagtt atcagtagtg aaaaccatct tgttgaaaga gaacttccct      780

ggagaaaaca tagtttcaaa aagcttttct tctcactctg atctgattac aggtgtttat      840

gagggaggct taaaaatctg ggaatgtacc tttgacctcc tggcttattt cacaaaggcc      900

aaagtgaaat ttgctgggaa aaaagtcttg gatcttggtt gtggatcagg tttactaggt      960

ataactgcat tcaagggagg gtccaaagaa attcactttc aagattataa cagtatggtg     1020

attgatgaag taaccttacc taatgtagta gctaactcca ctttggaaga tgaagaaaat     1080

gatgtaaatg agccagatgt gaaaagatgc aggaaaccaa aagtaacaca actatataaa     1140

tgccgatttt tttctggtga gtggtctgag ttttgtaagc ttgtactaag tagtgaaaaa     1200

ctttttgtaa aatatgatct cattctcacc tcagaaacca tttacaaccc agattattat     1260

agtaatttgc accagacttt ccttagactg ttaagtaaaa atggacgtgt acttttggcc     1320

agcaaagcac attattttgg tgtaggtgga ggtgttcatc tctttcagaa gtttgtagaa     1380

gaaagagatg tttttaagac cagaatactc aaaataattg atgaaggatt gaagaggttc     1440

ataattgaaa taacttttaa gtttcctggt taattaacat tcactgagta tccaaaatga     1500

aataaacaga aggaccaaaa a                                               1521


<210> 797
<211> 920
<212> DNA
<213> Homo sapiens

<400> 797
ggttccgcgg cggccacgct ccgggagact tccggcaggg cgggcgcggg gtcttggcga       60

acggtcttcg gaagcggcgg cggcgcgatg accacgctac gggcctttac ctgcgacgac      120

ctgttccgct tcaacaacat taacttggat ccacttacag aaacttatgg gattcctttc      180

tacctacaat acctcgccca ctggccagag tatttcattg ttgcagaggc acctggtgga      240

gaattaatgg gttatattat gggtaaagca gaaggctcag tagctaggga agaatggcac      300

gggcacgtca cagctctgtc tgttgcccca gaatttcgac gccttggttt ggctgctaaa      360

cttatggagt tactagagga gatttcagaa agatatgagg aaagcacttt ccagggatac      420

tgagaagaaa tccatcatac cattacctca tcctgtgagg cctgaagaca ttgaataacc      480

ctgggcagtg gttcttaggc agatactcta gatgctttat ggacaatatt attttcattg      540

gatgattctg gagctctatt aggagaaaag taatcatttt aggtcttaaa gacttcaaga      600

aaatacaggt tatcaattta ttttaaatct cattgtttcc agttagcaat atcataccta      660

ttaaagctgt tcattgtaac aaaattcaat caaaaaggca gctaggtcag aaggaaacat      720

accactctca tggttcatag tattcactgt atgtatgcta gggaaaagac ttgctccagt      780

ctcctcctca gttctgtgcc tgagaaccac tgctgcatat atttgttttt aaattttgta      840

ttgaactgtt aattgaagct ttaaaagcat atatgaaatg tataaatcta agatgtataa      900

tacattattg actctatgaa                                                  920


<210> 798
<211> 2112
<212> DNA
<213> Homo sapiens

<400> 798
ggcagcggca gcggcggcgg gacgcggagg ctcccccggg attcggcctc agcagcgagg       60

cggcggcggc ggctgcggag gcgcaggcag caactgaggc agcggcaggc tcaggtgcag      120

ccgctgctca aagaaaatga acggcaccct ggaccaccca gaccaaccag atcttgatgc      180

tatcaagatg tttgtgggcc aggttccaag gacctggtct gaaaaggact tgcgggaact      240

cttcgaacag tatggtgctg tgtatgaaat caacgtccta agggatagga gccaaaaccc      300

gcctcagagc aaagggtgct gttttgttac attttacacc cgtaaagctg cattagaagc      360

tcagaatgct cttcacaaca tgaaagtcct cccagggatg catcacccta tacagatgaa      420

acctgctgac agtgagaaga acaatgcagt ggaagacagg aagctgttta ttggtatgat      480

ttccaagaag tgcactgaaa atgacatccg agtcatgttc tcttcgtttg gacagattga      540

agaatgccgg atattgcggg gacctgatgg cctgagccga ggttgtgcat ttgtgacttt      600

tacaacaaga gccatggcac agacggctat caaggcaatg caccaagcac agaccatgga      660

gggttgctca tcacccatgg tggtaaaatt tgctgataca cagaaggaca aagaacagaa      720

gagaatggcc cagcagctcc agcagcagat gcagcaaatc agcgcagcat ctgtgtgggg      780

aaaccttgct ggtctaaata ctcttggacc ccagtattta gcactccttc agcagactgc      840

ctcctctggg aacctcaaca ccctgagcag cctccaccca atgggagggt tgaatgcaat      900

gcagttacag aatttggctg cactagctgc tgcagctagt gcagctcaga acacaccaag      960

tggtaccaat gctctcacta catccagcag tcccctcagc gtgctcacta gttcagggtc     1020

ctcacctagc tctagcagca gtaattctgt caaccccata gcctcacttg gagccctgca     1080

gacattagct ggagcaacgg ctggcctcaa tgttggctct ttggcaggaa tggctgcttt     1140

aaatggtggc ctgggcagca gtggcctttc caatggcacc gggagcacca tggaggccct     1200

cactcaggcc tactcgggta tccagcaata tgctgctgct gcgctcccca ctctgtacaa     1260

ccagaatctt ctgacacagc agagtattgg tgctgctgga agccagaagg aaggtccaga     1320

gggagccaac ctgttcatct accacctgcc ccaggagttt ggtgatcagg acctgctgca     1380

gatgtttatg ccctttggga atgtcgtgtc tgccaaggtt ttcatagaca agcagacaaa     1440

cctgagcaag tgttttggtt ttgtaagtta cgacaatcct gtttcggccc aagctgccat     1500

ccagtccatg aacggctttc agattggcat gaagcggctt aaagtgcagc tcaaacgttc     1560

gaagaatgac agcaagccct actgagcgtg ctcccctctg agactggagt gagagggtct     1620

tctgattcct gccgtttgtt catcgttgtg cctaaagcat gtcgatgtgg cgtcaagtac     1680

atcgtccaaa tccctgtctc ttcagcttct ctgatgcttg aactctcacc tttgaccttg     1740

tgttgacctt tgatgctgat gtgtattttt attatgtttg tttctttctt cgtttttttt     1800

tctttttttc tttccttttt ttttcctttt gtgctgccaa attggttttg ctagaacgac     1860

tgctgaaggg gaaatattta aacttgcatt tgaatataaa aaaaatctat ttttctagaa     1920

cttcataaga taaccacttg attttgtgat tccaattctt tgtaattgtc ttcagagcag     1980

ccctactagc acataccgcg tggtgtttgt atttctgtga acacacagcc agtccgtttc     2040

taggctttgt ttctctgtgt gcttagtttt aaagacaact ttgaagtaaa caatgaaata     2100

aaagatgtca ct                                                         2112


<210> 799
<211> 1613
<212> DNA
<213> Homo sapiens

<400> 799
ctgcctgtca gatgcctcat tcccacctgt gatgctcaga gagaaaccat gagccctgaa       60

aaacaccata ttgttttgtg atgtcacctc tggaatgttc tgagtgtttt ggtgaccaac      120

ttctgcatag gacctatacc tggcaactca cattgcactc aaggccaaat tatacaagaa      180

aaagagatac cagatctgaa agcctagaaa ttccaatcag tgtggttcta cctcagaggg      240

gcacagccga acccttcccg aggctccaca acttgtacag cacccctcgc tgcgcgcagc      300

aggccgccct gccccggctg agccgcagga tggcgagcca gcactcctat ccactgaacc      360

gcttctcctc cgtgccttta gaccccatgg agcgccccat gtcccaggcc gacctggagc      420

tggactacaa cccgccgcgg gtgcagctca gcgacgagat gttcgtgttc caggacgggc      480

gctgggtaaa tgagaactgc cgcctgcagt ctccctactt ctccccatcc gcctccttcc      540

accacaagct gcaccacaag aggctggcca aggagtgcat gctgcaggag gagaacaagt      600

ctctgcggga ggagaacaag gccctgcgcg aggagaaccg gatgctcagc aaggagaaca      660

agatcctaca ggtcttctgg gaggagcaca aggcctcgct gggccgagag gagagccggg      720

ccccctcgcc actgctgcac aaagacagcg cgtccctgga ggtggtgaag aaggaccacg      780

tcgccctgca ggtgccccgt ggcaaggagg acagcaccct gcagctcctc cgggaggaga      840

atcgcgcgct gcagcagctg ctggagcaga aacaggccta ctgggcgcag gcagaggaca      900

cggccgcccc tgccgaggaa agcaagcccg ccccctcacc ccacgaggag ccctgcagcc      960

ccgggctgct gcaggaccag ggctccggcc tctcctcccg cttcgaggag cccaaagggc     1020

ctccggcccg gcaggaggac tccaaggagc tgcgcgccct gcggaagatg gtcagcaaca     1080

tgtccgggcc ctccggggag gaggaggcca aggtgggccc gggcctgccc gacggctgcc     1140

agcccctgca gctgctgaga gagatgaggc aggcgctgca ggccctgctc aaggagaacc     1200

ggctcctgca ggaggagaac aggaccctgc aggtgctacg ggcagagcac aggggcttcc     1260

aggaggagaa caaggccctg tgggagaaca acaagctgaa gctgcagcag aagctggtca     1320

ttgacaccgt gaccgaggtc accgcgcgca tggaaatgct catcgaggag ctctacgcct     1380

tcatgccggc caggagccag gaccccaaga agcctagcag ggtctgaggc ctcggccttg     1440

caccgggacg ccgagtttgg gacaccgaac actgggcaaa agagaatccc ctgccttcct     1500

ttgtcgtcct cgccttcccc agccagttcg tacctattga aaagcagcgt tagcagcctt     1560

cctaaactca gagttttaat aaaggtgtga ggaggctggg gccagttgac acc            1613


<210> 800
<211> 1520
<212> DNA
<213> Homo sapiens

<400> 800
gaggtggtaa ccgtgatagt agcagctccg gcggcagcaa cagcgactac gagggatggc       60

ggcggctgca gcaggaactg caacatccca gaggtttttc cagagcttct cggatgccct      120

aatcgacgag gacccccagg cggcgttaga ggagctgact aaggctttgg aacagaaacc      180

agatgatgca cagtattatt gtcaaagagc ttattgtcac attcttcttg ggaattactg      240

tgttgctgtt gctgatgcaa agaagtctct agaactcaat ccaaataatt ccactgctat      300

gctgagaaaa ggaatatgtg aataccatga aaaaaactat gctgctgccc tagaaacttt      360

tacagaagga caaaaattag atagtgcaga tgctaatttc agtgtctgga ttaaaaggtg      420

tcaagaagct cagaatggct cagaatctga ggtgtggact catcagtcaa aaatcaagta      480

tgactggtat caaacagaat ctcaagtagt cattacactt atgatcaaga atgttcagaa      540

gaatgatgta aatgtggaat tttcagaaaa agagttgtct gctttggtta aacttccttc      600

tggagaggat tacaatttga aactggaact tcttcatcct ataataccag aacagagcac      660

gtttaaagta ctttcaacaa agattgaaat taaactgaaa aagccagagg ctgtgagatg      720

ggaaaagcta gaggggcaag gagatgtgcc tacgccaaaa caattcgtag cagatgtaaa      780

gaacctatat ccatcatcat ctccttatac aagaaattgg gataaattgg ttggtgagat      840

caaagaagaa gaaaagaatg aaaagttgga gggagatgca gctttaaaca gattatttca      900

gcagatctat tcagatggtt ctgatgaagt gaaacgtgcc atgaacaaat cctttatgga      960

gtcgggtggt acagttttga gtaccaactg gtctgatgta ggtaaaagga aagttgaaat     1020

caatcctcct gatgatatgg aatggaaaaa gtactaaata aattaatttg ctctcatcgt     1080

attgtgtata ttcacctaat gcccattgtg tattgatatt gcattcttga attttgaaca     1140

ctgaatatct ttttgaaaga ttatacttct ttacctcttt gtgctttaga aattattttc     1200

cttcaagtgt tcaagtctaa tgaagaatga agataacatt ttatcacttc tgtccttaaa     1260

ggtttcagac atggtgaaac tgaataaagc atgtcatttg ctcctagata gattcattct     1320

atctagttgt ggggatggag aaatctttaa tggtatattt tcggttattg ccttattttt     1380

gatacagtat tctgtcagta atttattaga cctggcagct ttgggtgagc ttagattttt     1440

caccttcagt gttacattgt gtttgctttt aaaaactgct tttgaatgga gttgtaaata     1500

caatttttct atgaagatgt                                                 1520


<210> 801
<211> 6351
<212> DNA
<213> Homo sapiens

<400> 801
aaaacggaag gtggttgtcg tccgttccca agctggtttg aaactagggg tcgggctcgg       60

ccgtcgtcgt tgtttgtcgc cgcatccccg cttccgggtt aggccgttcc tgcccgcccc      120

ctcctctcct cccttcggac ccatagatct caggctcggc tccccgcccg ccgcagccca      180

ctgttgaccc ggcccgtact gcggccccgt ggccaccatg tccctgcacg gcaaacggaa      240

ggagatctac aagtatgaag cgccctggac agtctacgcg atgaactgga gtgtgcggcc      300

cgataagcgc tttcgcttgg cgctgggcag cttcgtggag gagtacaaca acaaggttca      360

gcttgttggt ttagatgagg agagttcaga gtttatttgc agaaacacct ttgaccaccc      420

ataccccacc acaaagctca tgtggatccc tgacacaaaa ggcgtctatc cagacctact      480

ggcaacaagc ggtgactatc tccgtgtgtg gagggttggt gaaacagaga ccaggctgga      540

gtgtttgcta aacaataata agaactctga tttctgtgct cccctgacct cctttgactg      600

gaatgaggtg gatccttatc ttttaggtac ctcaagcatt gatacgacat gcaccatctg      660

ggggctggag acagggcagg tgttagggcg agtgaatctc gtgtctggcc acgtgaagac      720

ccagctgatc gcccatgaca aagaggtcta tgatattgca tttagccggg ccgggggtgg      780

cagggacatg tttgcctctg tgggtgctga tggctcggtg cggatgtttg acctccgcca      840

tctagaacac agcaccatca tttacgaaga cccacagcat cacccactgc ttcgcctctg      900

ctggaacaag caggacccta actacctggc caccatggcc atggatggaa tggaggtggt      960

gattctagat gtccgggttc cctgcacacc tgtcgccagg ttaaacaacc atcgagcatg     1020

tgtcaatggc attgcttggg ccccacattc atcctgccac atctgcactg cagcggatga     1080

ccaccaggct ctcatctggg acatccagca aatgccccga gccattgagg accctatcct     1140

ggcctacaca gctgaaggag agatcaacaa tgtgcagtgg gcatcaactc agcccgactg     1200

gatcgccatc tgctacaaca actgcctgga gatactcaga gtgtagtgtt ggtggcgctg     1260

tgcccacgag gcaggggctt ttgtatttcc tgcctctgcc ccacccccaa agtaagaaga     1320

aacatgtttc cagtggccag tatgtctttc attgctttgc acccactgtt accagaagct     1380

gctctaggag ttcctggcca gtcaccccat cgccctctgt ggcagactca gtgctgtgtg     1440

gcgcctcctc agcccagggc tgagttttaa gattttctct cctttcctct tctcctttgg     1500

ttcctcaatt aaaaaatgtg tgtatatttg tttgtcaggc gttgtgttga ggagcagttc     1560

acgcactggc tgtgtctatt cctctgccca ggtgtctctg tttgctgccc aaggcagcag     1620

ttcatgtctc gtccatgtcc atgttcgtgt tagcacttac gtgggaacaa ataccaattt     1680

gtcttttctc ctagtatcag tgtgtttaac aaattttaac tttgtatatt tgttatctat     1740

caggctaatt tttttatgaa aagaatttta ctctcctgct tcatttcttt gtcttatagt     1800

cctccctctt tgcaccttct tctcttccct cagtgcctgg agctggtact gggcccctgg     1860

ccccatgagc agtttgcctt cttgagtcac tgcctgtgta gtacatacct gaccgggagt     1920

ccaaaccacc ttggtgctct gaagtccact gactcatcac acctttctta gcctggctcc     1980

tctcaagggc attctgggct tgtaaacaga cataggaagc ctctgtttac cctgaagcac     2040

cactgtccag cccattggtt cccactggca gcatggtaga gctgagagaa acaggctctc     2100

agggtacctg acttgagggg aatcgtttca tgaagctgaa cttcaagcat atttccagta     2160

cattctttca gagtctgttt ttccatccaa atataagccc caggccattc cacttagtgt     2220

cttttcaatg ataggcaaga atgatatctg agttgaactt cggtgcttct gttgtttgag     2280

tttactgtgc ctggtggtat attgggcatt ctttggattg agtgttctga ggtgagagag     2340

tcttcccgag gcatcctgtc tgtgcttcca accctgaaca agaccttaca tgagagatgg     2400

actgatggac tgcggcaatc ctgggctgtc aagtggatag atagttaaaa agcattatac     2460

tgtgggtaat gaaaagggag gaaaaaaaaa gaaggaaaag gaattataga cccccagggt     2520

cagccagtta agagctctac ccacacctgt caacccctct ctcccccagt ttaggttctg     2580

agcagtattg gacttgtagc ctgcagttgt cttttgactt gcaggccgca ggtgtctttc     2640

tgttatgtga atgagttcca tggaggggca tatgtgtgat tccaccgtta gatgagccct     2700

tggggcaggc agtttgggat gtgctcttgg gggaaagttg gctgtttcct tgcgctctgc     2760

tcctacccga aggtttttaa gtccctctga attgctcatc tgagattagt agagtagcag     2820

gcctgaagga tgatggtttt gtcctctttg gttctcacct gcttgagaag taaaacagta     2880

actttgttct tctgggccct taagcttttt tggttaagtc ttccttttca gaagtagatg     2940

tcattatatg ccaaaagtct agctctttgc tttaccatac agggacctgt cccaaagaaa     3000

aaggctcttt ttttagccag catatttccc cttctaccct tttactttgt tgttctgatt     3060

ttaggactct ggctggccat gtgcttgtgg ttgcctctcc tgcatttgcc actggatttg     3120

cactgcatcg tttggagata caaagcgagc agttcttggt cagaaccctc ctctgctttt     3180

cattgtgttt gataatggtt actgggtcct tctctcaagg gtagcaaggc caagctgatg     3240

gctgcttgtt taggaggcca tcagttcctt cctgtggaga agggtctgaa atggaagtca     3300

gtggtagaag gggctggtct gctgggcagg gcttacatcc actgagttct aagattcctt     3360

tcctgatctg cacctacgcc tggtctgtat ggtggaattt gtcagctgga actcagaaac     3420

aacaacttga aaaaaaaata ataattagaa catatttgca taagatagct atttactctg     3480

gaaaccaaca acttttgaga tttcccttgc cctgtggacg cccagctcct gtcatccttc     3540

cttaggtcct gcagtacagt cttcccctga atgccaccgg ggacccaggg ggactccacc     3600

cccctaagca agcacacaca tactcacagt tgatgagttg ctggtctttg agtcccagct     3660

ctcttaccct ccctttactc caccagcccg acgacccatg actgaggagg ggatttctac     3720

agtctcagga tttagaaagt ctgtaagcca tccatgctcc agaaagcacc gatctgttgt     3780

agttgcaaaa acaactctgt aatttgttga ggttctcaaa ctgacagcca gcgagactgg     3840

gtgggaggcc ctggatctgt tctccctgac tgcgggagga gcagccacta ggactttagc     3900

aggaagccca catggaggct ccgccaggct gtggcccagc tggtgatggc ccttttgctc     3960

ctggcagcct gaggcacagc tgcctgtatt gtcctcatct gttctgactg aaggatggag     4020

gtgctgaata aattaggcct caggcctcta ccaccagaga gctggagaat gggtccacgt     4080

cattcaagga cctgaatttt ttatgctcag gagcattgga atcctcttct tccagggagg     4140

aattagcctg caaggttagg acttgaagag ggaaggtatt taataactgg gcgaggatgg     4200

gtgtggtggc tcacacctgt aatcccagca ttttgggagg ctgaggtggc cagatcccaa     4260

ggtcagaaga tcgagaccat cctggctaac atggtgaaac cccatctcta ctaaaaatac     4320

aaaaaaaaat tagccggggg tggtggcggg tacctgtagt cctagctact tgggaggctg     4380

aggcaggaga atggcgtgaa cctgggaggt ggagcttgca gtgagccaag atcgtgccac     4440

tgcactccag cctgggcgac agagcaagac tccgtctcaa aaaataaaaa aaaaaaaaaa     4500

ataggtgaaa attccttata aatccaggat tggctctgag agaactggct aagattcagg     4560

aagaaacaaa aaattcagaa tcctacaagg ttttgatgac aattagggcc aaaattttag     4620

gaggagatgt aggatgcagg agaaaattaa agtgttttct ttatatcaga ggaggaaata     4680

gtagaggtca gtgaaggtct ggggtaggga aacattcaga ctgtccattg catggctgtg     4740

gagtgagact gcccttagcc tgggtcagcc ttcctgggcc ataaattggg catccgtgat     4800

gctaggtaac tgtgggaaca aaatgacagc ttagagcagc catgggtgat gtttggtggt     4860

aaaaaaccta caggcgtttg gggtcccatg attgttccag accatgactc ttcctggttg     4920

tgggtttgtt acagagcagg agaagcagag gttatgacag ttatgcagac tttccccctc     4980

ctttttctct tttctcttcc ccttgctttt ccactgtttc ttcctgctgc cacctgggcc     5040

ttgaattcct gggctgtgaa gacatgtagc agctgcaggg tttaccacac gtgggagggc     5100

agcccagtac tgtccctctg ccttccccac tttgagaata tggcagcccc tttcattcct     5160

ggcttggggt aggggagacc attgaagtag aagcctcaaa gcagactttt ccctttactg     5220

tgtgtactcc aggacgaaga aggaagatca tgcttgatac ttagattggt tttcccaggg     5280

aagagggcgg agcagagcaa agtcactgtg aaccctgggc caggccctgg ctgggccagc     5340

tcctgagagc gtctcgtgtt gcagaccctt gcccacttca cccacctgca ccttctcccc     5400

ctctcacagt gtcactgctg ctaatggtca aagtcaaatg tgtggccaca tgggatgggc     5460

caggtcctct caggctactt tctggatgtc atttttaaaa tatggaaaca tgcaggtgcc     5520

ttcccaaaga ggcttggact ggtatatcca acgagaaaca aataagctaa agaaagttta     5580

aactcaagaa gaaagatgtt gacagtctat gtaacagctg gaaagtttat aggcacccac     5640

ctttgggaca acccagtgat tatgaacatg tgatatctac tatttaaaag aaatgttctc     5700

accttgggtt gattgtggta taccatgtgt tatgaaaatt gttgagctga agctttgaat     5760

cgatttagtt gagtctgact cacttgcttt ggttcctgtg tattttacta cccctcttgt     5820

cagtgacctt ccttccccac cccacccaga gtgaatttgt agcatgattg tataaacctc     5880

tatgtagaaa atggagattt cttgctctga aatgttaagc tctaactgat ccatttctgt     5940

gtcctttagc ctagtatgtc tgaacttcca ttcttgttat atatttaaac tttccctcta     6000

tattataggt tttgtggcat ccacggtcag gtgtagagga agctgcccct tgcagaactg     6060

tactgtaata tttttctttt ataaatattt tcacaggact gattgtacac agggcttgta     6120

ataaaatttt aacactgtgc tgtgaaacaa ctatggggaa tctccattga aggctacttc     6180

atgggcacct gaaagtggag tgttatagct atgactttct atttcttgtt tcctaagtaa     6240

attaaaccta attttcaccc tttcattctg tttcagcctc ctgtataaga agtaccgtat     6300

tttctgccca tcatactttg taataaaact tgaacatgta tagattgact g              6351


<210> 802
<211> 2717
<212> DNA
<213> Homo sapiens

<400> 802
gggcaatcgg cgcaggccct tcgtcgtgcc ccgcctcgtc tgccccgcca gcgcgtcgag       60

ggaggggcca gcgacacatg gcctagtaac tgtccggccg cggcgctggc ttaagccatg      120

gctgagggta gccggattcc tcaggcccgg gcgctcctac agcagtgcct gcacgcccgg      180

ctgcaaattc gcccagccga tggggacgtc gcggcccagt gggtggaggt ccaaagagga      240

ctggtgatct acgtgtgctt tttcaaggga gctgataaag aacttcttcc caaaatggtt      300

aatacactgt taaatgtgaa attaagtgag acagaaaatg gcaagcatgt ctctatattg      360

gatctacctg gcaacattct tattatccct caagctaccc ttggaggaag actaaaagga      420

agaaacatgc aatatcactc taactctgga aaagaagaag ggtttgaact ttactctcaa      480

tttgtgactc tatgtgaaaa agaagtagct gctaatagca agtgtgctga agctagggtt      540

gtagtggaac atggcactta tgggaacagg caggtgttaa agctggacac caacggacca      600

ttcacacact taattgagtt ttgaaaatga aaaactagtt tctatagctg ttttctggta      660

tgaaatgatc taaagtataa ttagattttc ttccccttaa tcttgaatat actaatcttc      720

agcattttta gacaggaaaa tcttgggttt catatataac tctgcacctg ctaattggat      780

gactttgcca agtcacctaa actctggatc tcagtcacct tttgtcctac attcctctac      840

ccttctactt gaaaatttga aatatgctgt ctattcactt catagtcatt aaggaaatgt      900

tcttaattgt ttttttgttt ttgttttttt tttgagatgg agtcttgctc tgtcgccaga      960

ctggagtgca gtggcgcaat ctcggctcac tgcaacctcc acctcctgga ttcaagcgat     1020

tctcctgcct cagcctccca agtagctggg attacaggcg catgccacca tgcccagcta     1080

atttttttgt atttttagta gagatggggt ttcaccgtgc tggccaggat ggtctcgatc     1140

tcctgacctc gtgatccgcc cacctcggcc tcccaaagtg ctgggactac aggcatgagc     1200

caccgtgccc ggcctcttag ttgtttttta aaaattatgt acattttaag tattttgcaa     1260

tgaagaaatt catgcaaaca agaaaaacac atttcttata ccatcaaatt tgtgtagcat     1320

gtaataaaaa taactatttg tattaaaatt aggtaaactt cagcacaacc caattataac     1380

tttgttaatt ttgtttacta tttcagtttt ctgtatttcc atatgtaagt caccatttct     1440

tttaataata tgcatgaaaa tgtaatatag ggccaaatgt ggtggctcat gcctataatc     1500

ccagcacttt gggaggccga ggtgggagga tcacttgagc ccaggagttt gcgaccagcc     1560

tgggcagaat agcaagaccc agtctctaac atatacatat acatatagat atatatgtaa     1620

tatagaaggg ttattgtgtg ttatattact ttccagggac attcaaatgt tttacattac     1680

tttaagaatc tttacttgat ataagaacaa agtataaggg tttaaaagtt gtttttatta     1740

aacatactat ataaatgggt taatggtcta tttttcagtt tttaccaaaa tcatgtgtct     1800

cactttttgt cttcgctttt taaagaactg gttcatgaaa ttagtgttag ttcataaatt     1860

gtttaagaag ttccttttcc attgaattag attgctgtaa aagggagaaa aagggaagct     1920

tcccataaga atagtttgaa aacaaattga cttgttcatt tccatattat ctgcttgatg     1980

atatggagcc agtgtcaatt tttctgttag tgaatgtttt ggactagatg ttcccgtccc     2040

caaaatttat atgttgaagc ccttattaat gtgatggtat ctggagatgg ggctcctcca     2100

accatcccat cctggaacat ataagccaga aagaaagtag tctccagaaa cagaccatgc     2160

tgacaccttg agtttgaact tctaatcacc agaactgtga ggaaataaat ttctggtgtt     2220

taaaccaccc agtcctatgg tattttgtta gggcagtctg agctacgaca gtgatataag     2280

atagacagct agtaaggtaa acttttcaaa ggcaagagag gaagatatac aagaaattga     2340

aagaataatt aagtcagtaa gaggtaatat tcagttttgg caaactcctc tgacttgagt     2400

tgaaaatact tttttttttt aagagtaaaa accaaataac taattctaat tggcaaaaaa     2460

aggtaaataa ataaacatcc taagtagctg ctgaaatttc cgttgtgtct tatagtttct     2520

ttaggtctgt gttcctaaga tgcttaaaat ttttatcatg aaaaatccta ttttctctat     2580

acccttcctg tactgttcta ttttggaacc agagaatcaa taactggctt ggtaatgagc     2640

tcattgtcct taacttttgc tttattgatt cacaatacac ttactgaaat gtaataaact     2700

attcataaac ttgcaaa                                                    2717


<210> 803
<211> 4258
<212> DNA
<213> Homo sapiens

<400> 803
atggaagggg cgctgactgc ccgggacaag gtcggggttc aggattttgt gctattggac       60

gcgtacacca gcgaatctgc ctttgtcgac aacctccgca agcgtttcag cgagaacctc      120

atatacacat atattggcac cctccttgtg tctgtgaatc cataccagga gctcggaatc      180

tacactgtga gccagatgga actttatcaa ggggtcaatt tctttgaact gccaccacat      240

gtctacgcta tagccgacaa cgcttaccga atgatgtgtg ctgaactaaa taaccatttc      300

atcctcattt ctggagagag tggggcaggg aaaacagagg cctccaagaa aattctcgag      360

tattttgcag tgacctgccc aatgacccag tcactacaaa tagcccgtga cagactgctg      420

ttctccaacc cagtgctgga ggcttttgga aatgccagaa cgctccggaa tgacaactcc      480

agcagatttg ggaaatacat ggatatacaa tttgattttc agggcattcc cgtaggtggg      540

catatcatca gttacttgat agagaagtcc cgagttgtct accaaaacga aggcgagcgg      600

aatttccaca tcttctacca gctgctggca ggtggcgaag aggagcgcct gtcttacctg      660

ggactcgagc gagaccccca gctgtataaa tacctctcac agggtcattg tgccaaagag      720

tcatccatta gtgacaagaa tgactggaaa actgtttcca acgccttttc tgtcattgat      780

tttactgaag ctgacctcga gaatctcttt ggaattattg ccagtgtctt acacctgggg      840

aacattggtt ttgaagaaga cgaccaaggc tgtgccacta tcccagacac ccatgagatc      900

aagtggatag ccaagctcct gggggtccac ccatcagtcc ttctggaagc tctcacccac      960

agaaaaattg aagccaaaac tgaggaggtg atctgcccgt tgacactaga actctctgtc     1020

tacgctagag atgcaatggc aaaggctgtt tatggacgaa cgtttacttg gctggtcaac     1080

aaaatcaatt cctccttagt taacaaggat ttcaccagga aaactgtaat tggattactg     1140

gacatctatg ggtttgaagt ctttgacaag aatggttttg aacagttctg tataaattac     1200

tgcaatgaga aactccagca actgttaatt gagaggactc taaaagcaga acaggcagaa     1260

tatgaaatgg aaggcataga gtgggagcca attaaatatt tcaacaacaa gatcatctgt     1320

gatttggtag aagagagaca taaaggaatc atatctattc tggatgaaga atgcattcgg     1380

cctggtcctg ctacagactt gagtttcctg gagaaattgg aagagaaagt gggcaaacat     1440

gcacacttcg aaacccgtaa gctggctggt ccaaagggcc gaaagaggat tggctggatg     1500

gagttccgac tcctccacta tgcaggagag gtcacatact gcaccaaggg attcttggaa     1560

aaaaacaatg atcttcttta cagacatctg aaagaagtgc tgtgcaagtc caagaacatt     1620

atcctgaggg aatgcttcct gctggccgag ttagaaaacc ggaggaggcc cccaacagtg     1680

gggactcagt ttaaaaacag tctgagcagc cttctagaaa ccctcatctc taaggagccc     1740

tcctacatcc gttgcatcaa gcccaacgac aggaaagaac ccagcaaatt tgatgacttc     1800

ctcataaggc atcagatcaa atacctgggg ctgatggagc acctgcgggt gagacgggct     1860

ggttttgcat accgaaggaa atacgagcat ttcttgcaaa ggtacaagtc cttatgccca     1920

gacacctggc cgcactggca cgggcctcca gcagagggcg tggaacggct gatcaagtac     1980

atcggctaca aacccgagga atacaagtta ggcaaaacca aaatattcat tcgtttcccc     2040

agaactctgt ttgctaccga agatgccttt gaatttagta aacatcaact agttgcaaga     2100

atccaagcca cttacaaacg ctgcctagga aggagagaat acgtgaaaaa aagacaagca     2160

gccatcaaac tggaagccca ctggcgtggg gccctggctc ggaaggcaat ccaaaggaga     2220

aagtgggccg tgcggattat cagaaagttc attaaaggat tcatcagtcg caacaaaccc     2280

ctctgtcctg acaacgagga atttatcgtg tttgtgcgga agaattacat cttgaatctc     2340

cggtatcacc ttccaaagac tgtcctggac aagagctggc tgaggcctcc tggcatcttg     2400

gaaaatgcat cagatctgct caggaaaatg tgcgtgagga acctggtgca gaagtactgc     2460

cgcgggatca cagctgagcg gaaagcaatg atgcagcaaa aggtagttac aagtgaaatc     2520

ttcaggggaa ggaaagacgg ctacacagaa agtttaaatc aaccctttgt caacagtcgg     2580

atagatgaag gagacattaa tccgaaagtg cttcagctaa ttagccatga gaaaatccag     2640

tatggtgtcc cggtcattaa atatgacaga aaaggcttca aagcacggca gcggcaactc     2700

attcttactc agaaagcagc ttacgtggtg gaacttgcca aaatcaagca gaaaatagag     2760

tactcagctc tcaaaggtgt ctccactagc aatctgagtg atggaatctt agtcattcat     2820

gtttcaccag aggacagcaa gcaaaagggg gatgccgttt tgcagtgtgg acacgtgttt     2880

gaagcagtta ctaaactcgt catgctggtt aagaaggaga acattgtcaa tgttgttcaa     2940

ggaagtttac agttttttat tagtccggga aaagaaggca caatagtttt cgacactgga     3000

ctggaagaac aagtctataa aaataaaaat ggacaattaa cagtggtgtc agtccggagg     3060

aagtcctgat agaggatgac gtctgacctc taccatcgcc atttttgctc caactgagga     3120

aactacaggg gaagtgggga ttggatccag ttagctacct cttcaaggta ccaggcccgc     3180

agcactaaca gatcacatct gaagaaactg aggggcgtta ggccaaagcc taatcccagc     3240

tcctcagctg ccccatggca ccttatttaa aatgtcacct tctggaagca gaccccaggt     3300

cacccgaagg cgcaattcta aacaccctcg acaggatcta tgttcagtgc gcagtccaac     3360

gtgtcattag agggtgggca agattctcta cctctgtcaa gctgccctga gacatgatga     3420

aatactgtgt acagcaagtt ctcaaataac atttcgttat atgttgataa gacatctgat     3480

tcctgggcag ggccactgtc tgggtggagt ctgtatgttc tccccatgtc tctgggtttc     3540

ttctgggtgc tctggtttcc tcccacgtcc ccaaggtgtg tgtgtcaggt gcactggcgt     3600

gtctatgcgg tcccagtctg agtgagtgtg ggtgcgtgag ccccgtgaga ggaggacatc     3660

ctgtccaggg tgggtcccgc cttctgccct gagctgctgg gattgggctc tggccatctg     3720

caaccctgaa cgtgcaggtt ggagaacgaa tgaatacaaa ttttattgta aaataaaaat     3780

gtatataaag catatgagca cacaaatgga caataaatgc cacagcgcaa aagcgtgtag     3840

cgagcctgcc acgcttgtga ctggggaggg gctccgtata atctcacctt tgcaagcgtt     3900

tatttactga tgtatgcggc caccactgtg accaccatca cttaccgatt caccaaaact     3960

taggtaatat ggtcttattt ttgatttaat taaatatacg tgtagctcat gtatttcaca     4020

gtttaatatg agaagtgctt tggtctttat ttagaaattg ggtgatgttt ttgtgcccag     4080

caacatgctg taggaattta actcttgttt acatccatta gcctcatggt tttgcttcaa     4140

gtctcagctt ccaagaacct atcgatgact tactgtgcat ggtctgagac taagtaaagg     4200

aaatttccta aagctgtgaa atttgaattt tgctttaaat aaatggaact cacatgtg       4258


<210> 804
<211> 1447
<212> DNA
<213> Homo sapiens

<400> 804
gaggtggggg cgggggcctt accccaccct ggcaccggca ggcgcgggcg gatgggggga       60

tgtcgcctag agccccccgg ccggcccaca aactcccgtc ccccttccgg ctctgcctgg      120

acgtccctgc gggccccggg ggaaagcacc caacttctcc cgcctcggct tctagcagaa      180

acgtgacggg gctggacttt gatcgccgag ggctctctgc tcttcagagt ctgcttggaa      240

cgggataaga gggatggtgc catccaggga agctctgctg ggaccaggca caactgccat      300

taggtgcccc aagaaattac agaaccaaaa ttacaagggc catggattgt caaagggaaa      360

agagcgagag cagagagcat cgatccggtt caagaccacc ctcatgaaca cactcatgga      420

cgtccttcgc cacaggccag gatgggtgga agtgaaggac gaaggggagt gggatttcta      480

ctggtgtgac gtcagctggc tccgggagaa cttcgaccac acctacatgg atgaacatgt      540

gcggatcagt cacttccgga accactatga gctgacccgg aagaactaca tggtgaagaa      600

cctgaagcgg ttccggaagc agctggagcg tgaggcagga aagctggagg cagccaagtg      660

tgacttcttc cccaaaacct ttgagatgcc ttgcgagtac cacctgtttg tagaggagtt      720

tcgcaaaaac ccaggaatca cctggatcat gaagcctgta gcccggtctc aagggaaagg      780

catcttcctc ttccgtaggc tgaaggacat cgtggactgg aggaaggaca caagaagctc      840

tgacgaccag aaagatgata ttcccgtgga gaactatgtg gctcagcgtt acattgaaaa      900

tccttacctg ataggaggcc gcaagtttga cctgcgtgtc tatgtgctgg tgatgtcgta      960

catcccgctg cgggcctggc tctaccggga tggctttgcc cgattctcca acacccgctt     1020

cacactgaac agcattgatg accagtatgt tcacctcacc aacgtggctg tgcaaaaaac     1080

atctcccgac taccacccaa agaagggctg caagtggacg ctgcagcgct tccggcagta     1140

cctggcgtcc aaacacgggc ccgaggcagt ggagacactc ttcagggaca tcgacaacat     1200

ctttgtcaaa agcctgcaga gtgtgcagaa ggtgatcatc agtgacaagc actgcttcga     1260

gctgtacggc tatgacatcc tcatcgacca ggacctcaag ccgtggctcc tggaggtcaa     1320

tgcgtcccca tcactgacag ccagcagcca ggaagactat gagctcaaga cctgcctcct     1380

ggaagacacc ctgcatgttg tggacatgga agcgagaagt ttgagggctg attctccttg     1440

ctggtaa                                                               1447


<210> 805
<211> 2711
<212> DNA
<213> Homo sapiens

<400> 805
agtcggagcg aagcggctgg cggagcagaa cggattgcag ggtcagccat gtcatctgag       60

cctcccccac caccacagcc ccccacccat caagcttcag tcgggctgct ggacacccct      120

cggagccgtg agcgctcacc atcccctctg cggggcaacg tggtcccaag cccactgccc      180

actcgccgga cgaggacctt ctcggcgacg gtgcgggctt cacagggccc cgtctacaaa      240

ggagtctgca aatgcttctg ccggtccaag ggccatggct tcattactcc agctgatggc      300

ggccccgaca tcttcctgca catctctgat gtggaagggg agtatgtccc agtggaaggc      360

gacgaggtca cctataaaat gtgctccatc ccacccaaga atgagaagct gcaggccgtg      420

gaggtcgtca tcactcacct ggcaccaggc accaagcatg agacctggtc tggacatgtc      480

atcagctcct aggagatggt ggaagcaccc cttgtcctgt gcttgtggga gactttgcag      540

ggaggaggca gcagacactg gagatgacat tcttccacac gagacggggc ttcagccggg      600

catggtccct ctcaagtatc tcctggagga aggggtatgg ggggcaggtg tggggtgtgg      660

ggtgttcccg gccatcagca cagcctatga ccattgcaac aacctctcac catctgaaga      720

gcattaaaag catttaaaaa ggagaggtgc ccactggtgg ctgagtggag gttccaaccc      780

catcccaggg agtggatcaa gggtggtatt tctccagctg ctcagacaca tgggctcaac      840

ccacagaatc cctcttcctc ctggagctgg aggccccaga ttcccagatc tggccccctg      900

gcagcctgac agggaccttg cgtgacttct ccaaggcaaa tttccaccta agtgcccctt      960

gcgcctctcc tggggcctgg gcaaagcagt tttctaattc ttggcttggt tggttctagg     1020

ggagctggct tgaagtgggt ggggaaaggc gggggtggcg gtctttggat tggacggatg     1080

ttgccttttg gtgcctttgc agtgggaggc ggcatagctg cctgtctggg gaagacagtt     1140

ctcccagcac tcccacccct gggcacagca ggctggtact gggaggctga acccctctta     1200

gagcctgacc ttttcatctg ccttctggtt gtgtgaccat cactcaacag ccatttcaca     1260

gcccctgtaa ttatggcggc ggggggctgg ggtggtggtg gtgggaaggg cttgtggaga     1320

ggacacagtc tttgtttaaa aactttgtcc cgatccatcc agaaaagagt aggtagcttg     1380

catcctgaca gcctggcaaa gtcaagaaag ttgaaggaga aacatacctt tggagagggg     1440

gttttcttta aaactagtgt taagaaatgc ttagggattt tttttttctt atttttcata     1500

actaaagctt tcacccagag ccggctctgt ttgcactttg ctgccgacat tgcaaacttt     1560

ttggcagggt gggagactga gtctcattct gtcacccagg ctggagtgca gtggcccgat     1620

ctcagcttac tgcaacctct gccctccagg gttctggcaa ttccgcctca gtctcctgag     1680

tagctgggat tacaggcatg cgccaccaca cccggttaat ttttgtattt ttagtagaga     1740

ccaggtttca tcatgttggg caggatggtc ttgaacccct gacctcagat gatctgccca     1800

tctcggcctc tcaaagtgct gggattacaa gtgtgagcca tcgcgcccgg cctgcaaact     1860

tttttgtagg tatttctggt aaacaaatcc ttaggttatc tttgctgtgg ttgtggtttg     1920

gctttagtca tgatttcaaa gtagaaatag ctaggcatta ttttttgaaa tatatgacct     1980

atatgtagtc aagaatccac tgaacagagg caagcaaacc ttttggaaac tggcttttgg     2040

gcagacagta aacgtccagt ttgatgctgg aagcatgaac agcttcatca ggtaggtact     2100

cctcaactct gatgagtttg tcctttcagc ctaagggggt ggaagggagt tgtttgagaa     2160

tagcaaatac gcatgttgat tgcgagtgtg tggagacaaa ggcagttccc accacagtta     2220

ggtcctggcc attgtttcct cgcctgcgat gctccttgta catcctcacc ctcctctccc     2280

gcctctgcct tctgctgggt caaaggtggc cttttctctc cagccttgaa ttgttccctg     2340

ttggcttccc aagggcccat ctgctggtac agtccacact tccacagcca agacccgaga     2400

gggctttcac tgccccaagc ctctctcctg tgaccctggg attctgtctt ggcagaatcc     2460

tttgtcagcg gctcttactc tgtccttcct gtttggccac agctctttca atcaatgggt     2520

attctagaac cgcaggatgt cagagctgga agggacgcga taccggttta cacaagggga     2580

aactcctcga ggctctggga gggacggagg gttttggtga cagagcgaga gctaaaattg     2640

aggattcctg aatccagatc ttgcctccca tcagccatct ttctcccaat aaatttttgt     2700

tttgtgcaag g                                                          2711


<210> 806
<211> 1562
<212> DNA
<213> Homo sapiens

<400> 806
cgagcaggcc gtttctgccg cgtccaccac aacctctgct gtatcagagg gggccttcgc       60

cgccgccgcc cccaccaccg cccctgccgc catcgccacc tccgccgctg ccgccttggg      120

gccctcctcc ttcaccgccc ccttcaccac ctctacacgt tctaggcctt ctgtcctgga      180

gaagaagcta tagtcgttct cccttgtggg cccggggcgc agccatggcg gacggcggcg      240

gcggcggggg aactggcgcg gtgggcggcg gcggaactag ccaggcctct gccggggcag      300

cgactggcgc tactggggcc agcgggggcg gtggccccat caacccggcc tcgctgcctc      360

ccggcgaccc gcagctcatc gctctcatcg tggagcagct caagagccgg ggcctttttg      420

acagcttccg ccgggactgc ctggccgacg tggacaccaa gccagcttac caaaacctga      480

ggcagaaagt ggataatttt gtgtcaacac atctggacaa gcaggaatgg aatcctacga      540

tgaacaaaaa ccagttgcga aatggtctga ggcagagtgt ggttcagtca gggatgttgg      600

aagctggagt agacaggatt atttctcagg tggtggatcc aaaacttaac cacatcttca      660

ggccacaaat agaacgagca attcatgagt tcctggcggc ccagaaaaaa gcagctgtgc      720

cagcaccccc tccagagccc gaaggccagg accctccagc tccatctcag gacacttcct      780

aagaatacgc cagacacctt ttgaaagcta atttttggtg aagaaatgga ttcggttaca      840

taagagtgca acttcagact gaagataggc caaggtcgtc actgatctca agatttcaac      900

cttgaccatg ggcagtgacc agattgaaag gggagcaagt tcggcagtgg gagagttgac      960

cgtgtcaccc cctgcattgt gctgccattt ggccagcctg tccaagggca tgacaccaag     1020

tagacactac agagagagaa acactacagc aacccagggt tgtcctgaaa cagactttta     1080

tacttgaaca tggagactgc acatggactt tagggtttgt gctgtgggat aaacggaagc     1140

tacagtgaga acatagccag tcccaaagac aatttcaaag aaaaatgaca gtaaagatta     1200

gctgggagta gtctttgaca gtgcttattt gatactgtct ctcagagttt gcaaaccaga     1260

ttgtacaagt cattagcgtc agatagcttt aaagttgtga ccttcttgta catgaatctt     1320

ctagccagtt tcctttcctt tgtaacgaaa catgaaatcc tagaatgtat gagaagttca     1380

gacattaggc ataaggaaac tcgtttgcag gctctctgtc cagggctgct tcctgtcctg     1440

gaggggccag tgagtcttag gtatgtttat tttattctca catttgtgtt tttttagaaa     1500

agtgaatggt caataaatgg cttatctttc ataataaaat tatttgatac ttttactccg     1560

aa                                                                    1562


<210> 807
<211> 10242
<212> DNA
<213> Homo sapiens

<400> 807
ccgagccggg agccgagcgc gctgggcgcg gccgtcccgc tgccgccgcc aagcccggag       60

tgcgccagcg gccatggttc ccgcggcggc gccgggcgcc tgagccccgg gacgcaagcg      120

ctggaggcgg gctgccggct gtgcgggcgc tccggagaga ccgacagaag gtgagcactg      180

tgggctatgg gatggatgag gtggagcagg accagcatga ggcccgactc aaggagctgt      240

ttgacagttt tgacacgacg ggcacagggt ccctggggca ggaggaactc accgaccttt      300

gccacatgtt gagcttggag gaggtggccc cagtgctgca gcagacatta cttcaggaca      360

acctcttggg cagggtacat tttgaccaat ttaaagaagc attaatactc atcttgtcca      420

gaactctgtc aaatgaagaa cactttcaag aaccagactg ctcactagaa gctcagccca      480

aatatgttag aggtgggaag cgttacggac gaaggtcctt gcccgagttc caagagtccg      540

tggaggagtt tcctgaagtg acggtgattg agccactgga tgaagaagcg cggccttcac      600

acatcccagc cggtgactgc agtgagcact ggaagacgca acgcagtgag gagtatgaag      660

cggaaggcca gttaaggttt tggaacccag atgacttgaa tgcttcacag agtggatctt      720

cccctcccca agactggata gaagagaaac tgcaagaagt ttgtgaagat ttggggatca      780

cccgtgatgg tcacctgaac cggaagaagc tggtctccat ctgtgagcag tatggtttac      840

agaatgtgga tggagagatg ctcgaggaag tattccataa tcttgatcct gacggtacaa      900

tgagtgtaga agattttttc tatggtttgt ttaaaaatgg aaaatctctt acaccatcag      960

catctactcc atatagacaa ctaaaaaggc acctttccat gcagtctttc gatgagagtg     1020

gacgacgtac cacaacctca tcagcaatga caagtaccat tggctttcgg gtcttctcct     1080

gcctggatga tgggatgggc catgcatctg tggagagaat actggacacc tggcaggaag     1140

agggcattga gaacagccag gagatcctga aggccttgga tttcagcctc gatggaaaca     1200

tcaatttgac agaattaaca ctggcccttg aaaatgaact tttggttacc aagaacagca     1260

ttcaccaggc ggctctggcc agctttaagg ctgaaatccg gcatttgttg gaacgagttg     1320

atcaggtggt cagagaaaaa gagaagctac ggtcagatct ggacaaggcc gagaagctca     1380

agtctttaat ggcctcggag gtggatgatc accatgcggc catagagcgg cggaatgagt     1440

acaacctcag gaaactggat gaagagtaca aggagcgaat agcagcctta aaaaatgaac     1500

tccgaaaaga gagagagcag atcctgcagc aggcaggcaa gcagcgttta gaacttgaac     1560

aggaaattga aaaggcaaaa acagaagaga actatatccg ggaccgcctt gccctctctt     1620

taaaggaaaa cagtcgtctg gaaaatgagc ttctagaaaa tgcagagaat gtgttagcag     1680

aaaagtttgg tgacctcgat cctagcagtg ctgagttctt cctgcaagaa gagagactga     1740

cacagatgag aaatgaatat gagcggcagt gcagggtact acaagaccaa gtagatgaac     1800

tccagtctga gctggaagaa tatcgtgcac aaggcagagt gctcaggctt ccgttgaaga     1860

actcaccgtc agaagaagtt gaggctaaca gcggtggcat tgagcccgaa cacgggctcg     1920

gttctgaaga atgcaatcca ttgaatatga gcattgaggc agagctggtc attgaacaga     1980

tgaaagaaca acatcacagg gacatatgtt gcctcagact ggagctcgaa gataaagtgc     2040

gccattatga aaagcagctg gacgaaaccg tggtcagctg caagaaggca caggagaaca     2100

tgaagcaaag gcatgagaac gaaacgcaca ccttagaaaa acaaataagt gaccttaaaa     2160

atgaaattgc tgaacttcag gggcaagcag cagtgctcaa ggaggcacat catgaggcca     2220

cttgcaggca tgaggaggag aaaaaacaac tgcaagtgaa gcttgaggag gaaaagactc     2280

acctgcagga gaagctgagg ctgcaacatg agatggagct caaggctaga ctgacacagg     2340

ctcaagcaag ctttgagcgg gagagggaag gccttcagag tagcgcctgg acagaagaga     2400

aggtgagagg cttgactcag gaactagagc agtttcacca ggagcagctg acaagcctgg     2460

tggagaaaca cactcttgag aaagaggagt taagaaaaga gctcttggaa aagcaccaaa     2520

gggagcttca ggagggaagg gaaaaaatgg aaacagagtg taatagaaga acctctcaaa     2580

tagaagccca gtttcagtct gattgtcaga aagtcactga gaggtgtgaa agcgctctgc     2640

aaagcctgga ggggcgctac cgccaagagc tgaaggacct ccaggaacag cagcgtgagg     2700

agaaatccca gtgggaattt gagaaggacg agctcaccca ggagtgtgcg gaagcccagg     2760

agctgctgaa agagactctt aagagagaga aaacaacttc tctggtcctg acccaggaga     2820

gagagatgct ggagaaaaca tacaaagaac atttgaacag catggtcgtc gagagacagc     2880

agctactcca agacctggaa gacctaagaa atgtatctga aacccagcaa agcctgctgt     2940

ctgaccagat acttgagctg aagagcagtc acaaaaggga actgagggag cgtgaggagg     3000

tcctgtgcca ggcaggggct tcggagcagc tggccagcca gcggctggaa agactagaaa     3060

tggaacatga ccaggaaagg caggaaatga tgtccaagct tctagccatg gagaacattc     3120

acaaagcgac ctgtgagaca gcagatcgag aaagagccga gatgagcaca gaaatctcca     3180

gacttcagag taaaataaag gaaatgcagc aggcaacatc tcctctctca atgcttcaga     3240

gtggttgcca ggtgatagga gaggaggagg tggaaggaga tggagccctg tccctgcttc     3300

agcaagggga gcagctgttg gaagaaaatg gggacgtcct cttaagcctg cagagagctc     3360

atgaacaggc agtgaaggaa aatgtgaaaa tggctactga aatttctaga ttgcaacaga     3420

ggctacaaaa gttagagcca gggttagtaa tgtcttcttg tttggatgag ccagctactg     3480

agttttttgg aaatactgcg gaacaaacag agcagttttt acagcaaaac cgaacgaagc     3540

aagtagaagg tgtgaccagg cggcatgtcc taagtgacct ggaagatgat gaggtccggg     3600

acctgggaag tacagggacg agctctgttc agagacagga agtcaaaata gaggagtctg     3660

aagcttcagt agagggtttt tctgagcttg aaaacagtga agagaccagg actgaatcct     3720

gggagctgaa gaatcagatt agtcagcttc aggaacagct aatgatgtta tgtgcggact     3780

gtgatcgagc ttctgaaaag aaacaggacc tactttttga tgtttctgtg ctaaaaaaga     3840

aactgaagat gcttgagaga atccctgagg cttctcccaa atataagctg ttgtatgaag     3900

atgtgagccg agaaaatgac tgccttcagg aagagctgag aatgatggag acacgctacg     3960

atgaggcact agaaaataac aaagaactca ctgcagaggt tttcaggttg caggatgagc     4020

tgaagaaaat ggaggaagtc actgaaacat tcctcagcct ggaaaagagt tacgatgagg     4080

tcaaaataga aaatgagggg ctgaatgttc tggttttgag acttcaaggc aagattgaga     4140

agcttcagga aagcgtggtc cagcggtgtg actgctgctt atgggaagcc agtttagaga     4200

acctggaaat cgaacctgat ggaaatatac tccagctcaa tcagacactg gaagagtgtg     4260

tgcccagggt taggagtgta catcatgtca tagaggaatg taagcaagaa aaccagtacc     4320

ttgaggggaa cacacagctc ttggaaaaag taaaagcaca tgaaattgcc tggttacatg     4380

gaacaattca gacacatcaa gaaaggccaa gagtacagaa tcaagttata ctggaggaaa     4440

acactactct cctaggcttt caagacaaac attttcagca tcaggccacc atagcagagt     4500

tagaactgga gaaaacaaag ttacaggagc tgactaggaa gttgaaggag agagtcacta     4560

ttttagttaa gcaaaaagat gtactttctc acggagaaaa ggaggaagag ctgaaggcaa     4620

tgatgcatga cttgcagatc acgtgcagtg agatgcagca aaaagttgaa cttctgagat     4680

atgaatctga aaagcttcaa caggaaaatt ctattttgag aaatgaaatt actactttaa     4740

atgaagaaga tagcatttct aacctgaaat tagggacatt aaatggatct caggaagaaa     4800

tgtggcaaaa aacggaaact gtaaaacaag aaaatgctgc agttcagaag atggttgaaa     4860

atttaaagaa acagatttca gaattaaaaa tcaaaaacca acaattggat ttggaaaata     4920

cagaacttag ccaaaagaac tctcaaaacc aggaaaaact gcaagaactt aatcaacgtc     4980

taacagaaat gctatgccag aaggaaaaag agccaggaaa cagtgcattg gaggaacggg     5040

aacaagagaa gtttaatctg aaagaagaac tggaacgttg taaagtgcag tcctccactt     5100

tagtgtcttc tctggaggcg gagctctctg aagttaaaat acagacccat attgtgcaac     5160

aggaaaacca ccttctcaaa gatgaactgg agaaaatgaa acagctgcac agatgtcccg     5220

atctctctga cttccagcaa aaaatctcta gtgttctaag ctacaacgaa aaactgctga     5280

aagaaaagga agctctgagt gaggaattaa atagctgtgt cgataagttg gcaaaatcaa     5340

gtcttttaga gcatagaatt gcgacgatga agcaggaaca gaaatcctgg gaacatcaga     5400

gtgcgagctt aaagtcacag ctggtggctt ctcaggaaaa ggttcagaat ttagaagaca     5460

ccgtgcagaa tgtaaacctg caaatgtccc ggatgaaatc tgacctacga gtgactcagc     5520

aggaaaagga ggctttaaaa caagaagtga tgtctttaca taagcaactt cagaatgctg     5580

gtggcaagag ctgggcccca gagatagcta ctcatccatc agggctccat aaccagcaga     5640

aaaggctgtc ctgggacaag ttggatcatc tgatgaatga ggaacagcag ctgctttggc     5700

aagagaatga gaggctccag accatggtac agaacaccaa agccgaactc acgcactccc     5760

gggagaaggt ccgtcagttg gaatccaatc ttcttcccaa gcaccaaaaa catctaaacc     5820

catcaggtac catgaatccc acagagcaag aaaaattgag cttaaagaga gagtgtgatc     5880

agtttcagaa agaacaatct cctgctaaca ggaaggtcag tcagatgaat tcccttgaac     5940

aagaattaga aacaattcat ttggaaaatg aaggcctgaa aaagaaacaa gtaaaactgg     6000

atgagcagct catggagatg cagcacctga ggtccactgc gacgcctagc ccgtcccctc     6060

atgcttggga tttgcagctg ctccagcagc aagcctgtcc gatggtgccc agggagcagt     6120

ttctgcagct tcaacgccag ctgctgcagg cagaaaggat aaaccagcac ctgcaggagg     6180

aacttgaaaa caggacctcc gaaaccaaca caccacaggg aaaccaggaa caactggtaa     6240

ctgtcatgga ggaacgaatg atagaagttg aacagaaact gaaactagtg aaaaggcttc     6300

ttcaagagaa agtgaatcag ctcaaagaac aactctgcaa gaacactaag gcagacgcaa     6360

tggtgaagga cttgtatgtt gaaaatgccc agttgttgaa agctctggaa gtgactgaac     6420

agcgacagaa aacagcagag aagaaaaatt acctcctgga ggagaagatt gccagcctca     6480

gtaatatagt taggaatctg acaccagcgc cattgacttc tacacctcct ttgaggtcat     6540

agccaaacca aagggtacac tcatatttgt gcactttact gaaatagatg aacatttcag     6600

taggttctca acttaaaatt aagcctaacc taaaactgcc agcaacacaa ctggagtttc     6660

catttatcat aattagtttt tctaaataga cccttatggg agtttgaaaa taaatactca     6720

catatttcac tacttaaatt attcccaaga tttgaattta ttttaaaatt ttaatagcca     6780

ccaagaatgt ggacatatga aaattcaaga acctaaaaaa taccagtttt gaatgagttt     6840

ttgtggtttt ggtttttttt ttaattatta caaatctatg tgtaaaatct agatatttga     6900

agtttgagat ctgatgagaa tggttgttat aaactttatt ttaaaaccaa atttaggtgt     6960

tcttacatat ttaaatactg gaaagtcatt ataatagttt tggttctttg aattggtaga     7020

caattagtag agtataattg gttaggaggc agggcttatt aagtggttat taaccgctga     7080

catcagacaa acccaaatct gtagaattct aaccttctaa cacctgtgac agtattacca     7140

ctcttcttgt attatagatt tagaactgat ttactcaatt gcactcttaa ctaatgttaa     7200

aagcttactt gctttaaaca gccttttctt ctttctctta aaagtttcat ttggggagct     7260

ggtcttctaa gaaacggata aagccacata attaaagcag ttgaactata gggaaagcac     7320

tgaacaaacc actttggagt aaatagctac tcttagaaaa gagggataag cagaccatgt     7380

aggttttctg tctctcaaat cttagagttc ataaatttac ttgaggttgc ctcaagaact     7440

cagggaacaa tactgtaaac tgtcttcctg aactactgta gggcctctct aagaatttga     7500

aatgtataaa ccatgtgacc tcatttattt gtcttatata tttacagcca tactagaatt     7560

tttatttcta cgtttttagt aaatttaata ttctggggga aaaaaggcct tgattttagg     7620

gttaaaaacc tgacttatag aagagtttat ttaatatagg tcaaaatttt ctgtgtttct     7680

tattccttct atacctcaaa tctgattcta agaatttctt actgtgataa tcattggcat     7740

gccacctgag gtcaaggagt gccaaatagg actttccact catgctcaag atcaaaactt     7800

tatagaacag tcaacatttt agattcggta accttttttt tcttccaatt ataatctctg     7860

ctagccactt ccgccagcag ttggtggaag acttactagg tgcagggcac tttccaagtt     7920

catcacaaca acctgcttgt tttcatgaga caataatccg aaaagttcgc tttgatatat     7980

tcctggaggg ccaagcccat ctatttacaa aaggtgaaca gcaaaatcaa gcactgcttt     8040

atgggcagga acacaagaga aagcaaactg cccaagaagt catcatgtca gaaactcaat     8100

ctcaacaaaa taatttccat cagggaactt cagggtttct tgggggctta tgagtctcac     8160

cggtcaaccc aggaggcctc actacaagag ccttgacaag gcactgtttt ttgtgggact     8220

gggagttcac actgatgaag caaacctttg aatttttgca cagctcttgt cagaaagccc     8280

tgagttcccc ctggataaag agttaatttt aatccttccc tataattata cttcaaaata     8340

tttgacatct gctattatgc cttctttaga tctttcttct gtggtgcaga catttctagt     8400

aagtgtttga ctacttgtat ggcattagct ttcacagaaa attgtttcac ttaaaactgt     8460

ggattggcct aggctaagga caaaaataaa ctaagtacct gtagtgtatt tatgtgatat     8520

gtgtcaagtt actcaaagtt attgctgttg gaactgaaca ataatatttc ccagatagct     8580

ggccttagca tgtgatcacg gttgttgtat ttttaatttt tgtcttttac agtatgagag     8640

gtgtaggtta atttgtttat ttcctataaa tttgtattta tgtgtatata aaatgtacaa     8700

tgaatgtaaa tatgactttc tggaaagttt agactacatt tagaatctct attcaaaatc     8760

aaaatgctgc tcaaatgaat ttaaccaaca tctaggtgct taatttctca ttttatccca     8820

cttatgagat tgggaaaaag atcaatatga gaaataccat acagatacct taaatgtatg     8880

catttgtgca acaatttttg agaaggtgag tggcaattta taatttagtt ggcaatttat     8940

aatagaactt atagctttta aaagaccttt taaagacatt aaatgtaaac ttaaaaatgt     9000

ttagatcttg tttcaaactt tacaatagca ttcttcaaaa tattaagtta tatattttat     9060

aggcatttag ttgcttatta aaagcactga ttttcaaact ttttgattta agaacaatta     9120

tttaagatcg tctcagaaga tgggatcttc gtttcaagaa aagggaatca agtttgcctt     9180

tgagataata cgttacacta agaaaaggaa aatgtggata gtaaaaccca cctctctcat     9240

cctattgtac tctcttctgc tttttagaag cctgcactta agcttagatt tgtgaaggga     9300

gagtagaagg ggagaagtag aaccacagtg ttttatttat ttttctaaaa ctcttactaa     9360

atccagattt tttaaactgt tttaaatgtg aattcttccc agaaatttca atgcattgca     9420

tatttagcct tcggcatatt tttcatgaat agatcatgaa gtcataggct tccaaggcat     9480

aggaagagat cttgcaggtc tagtatttta ataatgcact attacccagg gcagatatta     9540

tgagaaactg tttcttctct aagggtttat ggcagacttt gcttttttaa catgtgagaa     9600

atgaattttt tattttgtga tttatgtgat ttcttttgct gagtgaagga aaggagaaat     9660

tgttgctatt gtcagcatct taaaggtatt tccagtcaag gcaaggctaa gtgctttgtg     9720

atagtattaa gcaagtcatg ttttgaatgg attacctgta gtgactcatt ggaatgatat     9780

aattatacaa gtaatgccaa aaaccaagtc aaagcctaat taaccaaagc actcatttaa     9840

aaatcatcat gtttggacct atctggacct ctcagcactg taaaatagtt ttggttttgt     9900

ggcatatgaa tagctgttta acaaatcaaa gttagctttt tgcttctcag cttttttggg     9960

caatacaagt taagttctta atggggagac attatcatgg catgacttaa gggaacattg    10020

gtttgtgaag gaaaaacaga ttatctaaag ccatctctat gtttctgttc agataaagat    10080

taatgagttc tgtgtttata tcagctttgt atatttcatc ttagccattc tatcctagaa    10140

agattttaat gtgagcttaa gatgtaaata aataattttg caaacatgcc ttttgttttc    10200

tatataccct gaccttttaa taaagtttca gtgtatttat ca                       10242


<210> 808
<211> 3662
<212> DNA
<213> Homo sapiens

<400> 808
gccggggtgc ggagggagtc cctgaaactt ctcccaacag ccccagggcc aatcttccct       60

cagcccactc ccctcttcgc cagctcccag gtccccactc ctgtaccggg ggtggggtgg      120

ggagccaggc ccgtctcccg ctgggacaca cacaggggcc gggagcgggg acgggacccc      180

cgaggcgggg gggacgaacc gacagacaga cggctgggcg cccgccccag cgggcaggca      240

ggcaggagga ggcggaggcg ggggtacgac ggggagcact gggtctgggg agtttcctct      300

caactatcgg gggagaaact ccccgcagcc ggaggaaaga cccagacagt gttttcctcc      360

cgggggccgt gctcccccgc cccgcgtagc ggcggtcgcc gccaccggcg cctccacctc      420

taccatctcc tctttctcca ccacctcggg ccccggtgtc cccggccagc actatgccca      480

tcttactgtt cctgatagac acgtctgcct ctatgaacca gcgcagccat ctgggcacca      540

cctacctgga cacggccaaa ggcgcggtag agaccttcat gaagctccgt gcccgggacc      600

ctgccagcag aggagacagg tatatgctgg tcactttcga agagccgccc tatgctatca      660

aggctggatg gaaagaaaac catgcaacgt ttatgaatga attgaaaaac cttcaggctg      720

aaggacttac gactcttggc caatccctaa ggacagcttt tgatttatta aatttaaata      780

gattagtaac tggcatagac aactatgggc agggaagaaa cccttttttc ttggagccag      840

caataattat cacaattact gatgggagca agttgactac caccagtgga gtccaggatg      900

agcttcattt acctcttaat tctcctttgc ctggaagtga attgaccaag gaaccttttc      960

gttgggatca gagactcttt gcattagtgt tgcggttgcc tggcaccatg tcagtagaat     1020

cagaacagtt gacaggtgtg cctttagatg actctgcaat cacaccaatg tgtgaagtga     1080

caggcggccg ttcatattct gtgtgttctc caagaatgct taatcagtgt ctggagtcct     1140

tggtgcagaa agtacaaagt ggggtggtaa taaactttga aaaagcagga ccagatcctt     1200

cccctgtaga agatgggcag ccagatatat caaggccttt tggatctcag ccttggcata     1260

gctgtcacaa actcatatat gtcagaccaa atcctaaaac tggggttcct ataggtcatt     1320

ggcctgttcc agagtctttt tggccagatc aaaattcgcc aacactacca cctcgtacat     1380

ctcatcctgt agtgaagttt tcctgtacag actgtgaacc aatggttatt gataaacttc     1440

cttttgacaa atatgagttg gaaccttcac cactgactca atttatcctg gaaaggaaat     1500

ctcctcaaac atgttggcag gtgtacgtga gcaatagtgc aaaatacagt gaacttggtc     1560

atccttttgg ttacttgaaa gccagtacag cactgaactg tgtcaactta tttgtgatgc     1620

cttacaatta tccagtcctt cttcccctct tagatgactt gtttaaagtg cataaagcaa     1680

aaccaacatt gaagtggaga cagtcatttg aaagttattt gaagacaatg cctccctact     1740

atcttgggcc cttgaagaaa gctgttagga tgatgggagc acctaaccta atagcagaca     1800

gtatggaata tggacttagt tacagtgtca tttcatacct caaaaaactg agtcaacagg     1860

ccaaaataga atctgatcga gtcattggat ctgtaggcaa aaaagtagta caggagactg     1920

gaataaaagt ccggagccga tcacatggtt tatcaatggc atataggaaa gattttcaac     1980

aactcctcca gggaatttca gaggatgtcc ctcacagact gctagacctt aatatgaagg     2040

aatacactgg gttccaagtt gctttgctga ataaggattt gaagccacag acatttagaa     2100

atgcttatga cataccaaga cgaaatcttt tggatcactt aacaagaatg agatctaatc     2160

ttttgaagag cactcgcaga tttctgaaag gacaggacga agatcaagtg cacagtgttc     2220

ctatagcaca aatggggaac taccaggaat acctcaagca agtaccttct ccactaagag     2280

aacttgatcc tgatcagcca cgaaggttgc atacatttgg caaccccttt aagctggata     2340

agaagggtat gatgatagat gaagcagatg aatttgtggc tggacctcaa aataaacata     2400

aacgacccgg agaaccaaat atgcaaggga tccctaaaag acgtcggtgt atgtctccac     2460

tactaagagg cagacagcag aatcctgttg taaacaatca tattggggga aaaggaccac     2520

ctgcacctac aactcaagca cagccagatc ttattaaacc tcttcctctt cataaaattt     2580

cagaaaccac taatgattcg ataatacatg atgtggttga aaatcatgtt gcagaccaac     2640

tttcatcaga cattacacca aatgctatgg atacggaatt ttcagcatct tctccagcca     2700

gtttactgga acggccaacc aatcatatgg aggctcttgg tcatgaccat ttaggaacca     2760

atgacctcac tgttggtgga tttttagaaa atcatgagga gccaagagat aaagaacaat     2820

gtgctgaaga gaacatacca gcatcttcac tcaacaaagg aaagaaattg atgcattgca     2880

gaagccatga agaggtcaat actgaactaa aagcacaaat aatgaaagag atccgaaagc     2940

caggaagaaa atatgaaaga atcttcactt tactgaagca tgtgcaaggc agtttacaaa     3000

caagactaat atttttacaa aatgtcatta aagaagcatc aaggtttaaa aaacgaatgc     3060

taatagaaca actggagaac ttcttggatg aaattcatcg aagagccaat cagatcaacc     3120

atattaatag caattaaaag aaaatagaat gtggccactt atttcactat cttcttcaaa     3180

tacaaagtaa atacaagact gttgtgatct tgcattcatt ttctgacatg cattgttggc     3240

tatttgaaat actaaaagca aatctacaga tcctttttcc atcattttac agtgaccttt     3300

tcttcatttt ggtttatttt tgtaatgtga aaagtatcac tctaaaaaac atttttaatt     3360

taacaaacta aaaatattcc tccaaatctc ttgcttgtca ttgactcttg cgtgtcaatt     3420

tccctcaggt tctattttct taaaccaacc tttaaaattg tcacctctgt taaggttgaa     3480

ctttgccaaa aaaaaaagaa gttactttgt aatttttggg gaaaaaagca catacattaa     3540

aactaggtaa tgttttgtat atacagttat tttggatata ttattgtaag ttgtacaaat     3600

gtattttgaa gaatatttaa gaaaagcact tttgttattc catcaataaa tgctctattt     3660

ta                                                                    3662


<210> 809
<211> 7333
<212> DNA
<213> Homo sapiens

<400> 809
acttccttcg tctgggtggt tgccccagcg acacgttggg ccgaagagcg gtgttgggta       60

cccgagagac ccggcggtgg ggaagtcact tcctcccgaa gacgctgttt cctagcaacc      120

gccctccgcc tctgttatta gcccctcctc ctcgctcggt ccaggaccgg ctctgcgggc      180

gccgccaggc ccagaccaag ctactatcag aagttgaatt ctaataatta gctattttat      240

aaaggtaacg agaaaaaata cactatgtct gatgaagttt ttagcaccac tttggcatat      300

acaaagagtc caaaagttac caaaagaact actttccagg atgagctaat aagagcaatt      360

acagctcgct cagccagaca aaggagttct gaatactcag atgactttga cagtgatgag      420

attgtttctt taggtgattt ttctgacact tcagcagatg aaaattcagt taataaaaaa      480

atgaatgact ttcatatatc agatgatgaa gaaaagaatc cttcaaaact attgtttttg      540

aaaaccaata aatcaaacgg taacataacc aaagatgagc cagtgtgtgc catcaaaaat      600

gaagaggaaa tggcacctga tgggtgtgaa gacattgttg taaaatcttt ctctgaatct      660

caaaataagg atgaggaatt tgaaaaagac aaaataaaaa tgaaacctaa acccagaatt      720

ctttcaatta aaagcacatc ttcagcagaa aacaacagcc ttgacacaga tgatcacttt      780

aaaccatcac ctcggccaag gagtatgttg aaaaagaaaa gtcacatgga ggagaaggat      840

ggactagaag ataaagaaac tgccctcagt gaagaattgg agttacattc tgcaccttct      900

tcccttccaa cgccgaatgg catacaatta gaagctgaga aaaaagcatt ctctgaaaac      960

cttgatcctg aggattcatg cttaacaagt ctagcatcat catcacttaa acaaattctt     1020

ggagattctt tttcaccagg atctgaggga aacgcatctg gaaaagatcc aaatgaagaa     1080

atcactgaaa accataattc cttgaaatca gatgaaaata aagagaattc attttcagca     1140

gaccatgtga ctactgcagt tgagaaatcc aaggaaagtc aagtgactgc tgatgacctt     1200

gaagaagaaa aggcaaaagc ggaactgatt atggatgatg acagaacagt tgatccacta     1260

ctatctaaat ctcagagtat cttaatatct accagtgcaa cagcatcttc aaagaaaaca     1320

attgaagata gaaatataaa gaataaaaag tcaacaaata atagagcatc cagtgcatct     1380

gccagattaa tgacctctga gtttttgaag aaatctagtt ctaaaaggag aactccatcg     1440

acaactacct cttctcacta tttagggact ttaaaagtct tggaccaaaa accttcacag     1500

aaacagagca tagaacctga tagagcagat aacataaggg cagctgttta tcaggagtgg     1560

ttagaaaaga aaaatgtgta tttacatgaa atgcacagaa taaaaagaat tgaaagtgaa     1620

aacttaagga tccaaaatga acagaaaaaa gctgctaaaa gagaagaagc attagcatca     1680

tttgaggcct ggaaggctat gaaagaaaag gaagcaaaga aaatagctgc caaaaagagg     1740

cttgaagaaa aaaacaagaa gaaaactgaa gaagaaaatg ctgcaagaaa aggagaagca     1800

ctacaagctt ttgaaaaatg gaaagagaaa aagatggaat atcttaaaga gaaaaataga     1860

aaggagagag aatatgaaag agcaaagaaa cagaaagagg aggaaactgt tgccgagaaa     1920

aagaaagata atttaactgc tgttgagaaa tggaatgaaa aaaaggaagc ttttttcaag     1980

caaaaggaaa aagaaaaaat aaatgagaaa agaaaggaag aactgaaaag agctgagaaa     2040

aaagataaag ataaacaagc tattaatgaa tatgaaaaat ggctggaaaa taaggaaaaa     2100

caagaaagaa ttgaacgaaa acagaagaaa cgtcattcct ttcttgaaag tgaggcactt     2160

cctccgtgga gccctccaag cagaactgtg ttcgcaaaag tgttttgata attctagttc     2220

ttacattatt tggttattta tcggtttgcc aatattagcc atagatttaa aaccattcaa     2280

ttatttatag ttagaggaat atattttaat taaatgccag acactcctgc tgacaatgaa     2340

agaaatactt tggaatgtaa tcagtgaaag catttttttg aactgtagat aaactgcctc     2400

aaacaaagac ctaataatca gattgttttt accattaaga tacataagat tttatcatgt     2460

cctgataatt cttatggtgg agtgattcat gatctttttc attaagctct gtatgttatt     2520

taagtatatt taattccagt aataaaaagg aaatcatcta ggtaccataa tgatagaaat     2580

tattcctttt gtggatgatt gtgaatctag attcaggttt ttaaatgaag ggtcgctggg     2640

aagtgcgcat atattattcc ttctgaaact gatgtttagc tcaaagcagt tgcatttgta     2700

ctgtgctagt tagaattttc atcagttgag gcagtagctc agtagaactc taatcatcaa     2760

ggctttttat ttaagaattt tgccttatgt tttaatatga gtgtacttta tctgttccag     2820

gcttatgtga taatcatagg tactttataa tgagtccacc tctgaaattt ttctttctga     2880

attctatctc actttattat ttcagtgata ccaaaagaca tcaatgtcac agtagtgata     2940

tacttatgta ttagttatgg aaattccaca ggagttcaag gtcattatca ctataattat     3000

tttcctgact aaagccataa aggtgattta ggcaattatt gtcatcttag ctagtcctgt     3060

tttatagctt atattcagca gacagctgta tgggaaggta aatatgttga caatgtccac     3120

aaagccttta tttatttatt tatttgatct ctgcatgtcc tcgtagtaac tggtctcata     3180

cttgacctgg tcatctggtt taagacagac caagtgtatg ctcacggagc tgaaatgcat     3240

tagtcagttg tgcaatgagg agatgatgga tgagaatata tagttcctat ttattgagca     3300

tctaatatat aatctctact ggacctttac aaatgtattt aacatcttta caacaacttt     3360

tcagggtagg tgttaccggc ttcatcttac atataaaaat actggcgctc agataaacca     3420

agtaacttac cgtccatctg gagtgtgcct gagttgagat caaacgggat tcagtacgtc     3480

tgactgaatc tgcctccttc tgaaatctct atgctctttt tcacacttct ctgtagcctc     3540

agagactgcc aagttctgtc aagacctctg cataatatca acgttacaaa cacgttttaa     3600

cttttagagc ctaaaatcat gtattgttat ccaaagatga tctttctcta cagaaatagc     3660

tgcttgttct tagagatggt ggaggtcatt aaatctataa agtgagataa aaatccataa     3720

gatttcatga gttactcagg catcttataa ctactatcag aatatcagaa aactcagcaa     3780

gttatgtgac aaaggctttg agatgatcac tccagacgtt ccacatactg agcatcagcc     3840

ttcttgctgc agtgcatgtg caagataaga tgtcataggc agctttgtaa gattgtatca     3900

gtgctataga caattaagag aaatttcata gataaaacta gaaccctttc tatatggcca     3960

gaactgtaat actttatgaa attgatctga ttatcagcaa tatgtagtat cagcatggaa     4020

tttaggacct ctcttactca ttcctgtgtc ccccatagta ccaaaaacag tgcctgccaa     4080

aatagattaa aagtgtttat tgtattagct gtttagagct gaaaagatat ttacaaattc     4140

cagggaagta aaaggaaaaa aactgaaaaa ggtacagcta cttttgggga tgtgagatca     4200

tggatgtgta tcttatagat ttcacattat ttatttactt tccattattt tcttctacat     4260

tatcatattt agtggctaac cattattact tcttaggttg ttgtgagaac cgagttaatt     4320

aatgtaaact atttgacaca taataaggac ttaaatgttc attgttgtca ttattgattt     4380

attaccatga gccctacatt tccccattca tgagtgtgcg aacattaaca tagatagggt     4440

tgataatggt tatttgacat tacacatttt taggaagaag aaatttctgt cttgctggcc     4500

agtccaggct gtaacactca aaaaaacaaa acaaaacaaa acaaaacaaa aaaacagaaa     4560

gatgccttgt attagggcct tcctaaaaag aaagctaagt aagtattaat ttcttaggat     4620

tgcttctgag gtaggatgag gtgtttgcat agacccaaca agtcattcac ttcaaatttt     4680

ttttgtctta ctatgataaa taacatatta tttcctgttt acagcaacct gcactgaaat     4740

taactagttg aataaaatca cctcttctag cacaaataaa gctgagttcg gggaggtggg     4800

tgaaaataca gtactgttgt ttacttccta agatccaagg gagagaatca agcttggtaa     4860

tattctcttg aatatacatt tacctattta aaaggtatga ttttcccata tttccttagg     4920

aagtatgtca tgtcaatata gatatttact cattaggttt acattaattt gtattataag     4980

ggaatgttta attcaaatta aggacattaa aagtatatag actttcatat aaaagttccg     5040

gttttataaa ttgcgttgat cacttaaaga atgcagagat ctcaaagtaa agaaaacaaa     5100

ttttatgaat attttaaaac attacttaaa acaagtttcc ttagaaagca catttgtgga     5160

taaatttaaa tattaatact aaataataaa gtagtataca gaatttaaat ttcataataa     5220

tgaagaaagt ggtaatgcta tttaacttaa aagatgcaat atggcatttt agatcaagag     5280

gttaaagttt tcttaatgaa agaaagtaac gatttatggg ataaaaatat tccagtggtt     5340

tgtatttgct tcatacttca aaagtgttag tccatttatt gtttaaagtt atattgaaac     5400

tgatattttc actgctgcca aagcagtacc tgacagtaga taggtatcca cagtcttatg     5460

ttccttagag ttatagaact atgcctctga aaggggtttt aatactttaa taaacctggc     5520

ctaaactgtt ttatttctaa gttgaagaaa ctgattgtca agtactttga cttgtccaat     5580

ctcatacaac taactatggt acatctagag ttagatctca gtatcagggg tcccagttgt     5640

attctgctca ccattccaca atttcgatat tgataaaact ttcacactaa cttttgaact     5700

gtggttatta ttaatttagt tgattcatgt cctcttattt atctccttac tcctccactg     5760

ctgccttcat aactgtccac cagatcaaag ctatttgggt acctacactt taaagtgagg     5820

ggaaataatg aagtttctta aatcctgtgt catggactaa gatacaataa agaaaaggaa     5880

tttcacaaag taggggaaat tacgtgttag ttataatcat tcccaagaat aaactagtaa     5940

aagaaactta gatttcccta atttaatctt gactccgatt ttgatagtgc tatataaaaa     6000

ggtatttaaa cccatatgct tccttttaca taaaagaaag atatcaactt tcctagtttg     6060

catttacact ggctaatagg ataataaaat gctgtgtaaa tgttaaactg gaagtttctc     6120

tgagttattt ttactttaaa atttcatgtg attatgccat tttgaatatg tatattacat     6180

gtaattgtat aatgttaact cgggtaggca aaattcttgg tattaaattt aggatgtttt     6240

aaaaattatt aagaagatat taatgtctgc tttttgatag catatatttt catgtaatgt     6300

ttagtgtatt aaaatcaacc attcaagatt tattttattg ggtgacacta ttgactgtgt     6360

tccaaaatgc ccatagtgtt aggaaatgtg gtgtgagttt tatttgtggg ctaaggataa     6420

aataatcata tgctaatata ccttttatta taaatgacta aaaatttgga tataaaactg     6480

atgttttact acacaaatta cagagagaga taatataatt atataattat taaataatta     6540

gaaaatgcaa ataagcaaaa gtcacccatg ttcccagttc tcatctcctg aagatagtta     6600

taactaacat attattttgt actcttcctg ttaattagtt tctagtgtac tttctcctgt     6660

agctgaaatt aagctgagaa aaaaggaaga gatagttcct ccctcctctt tctctctccc     6720

actctgtctc tctcctgtgc tatctgtgtg tatatacaaa tatgtatgca tatatatata     6780

atgatgtaca taatatatat aaaatacaaa tactaatgtg catattttca aacatacaca     6840

tattttttat tatttgaaat aagaatgagt cagactacat atttggtagc cagatttttt     6900

tcactcagtg atatatcatg aacatatttc catgctaata taattttcta ataattttag     6960

atgctgtaac tacaatttca ttgttaatgg gcaatttgtt gctttacaaa tggtaaatta     7020

tatgataaat aatatgatca ttattcttgt agccaatatc attattagaa atgatggacc     7080

gcattaaagc tataaaatta aataagaatt tataaatgta aggagttatt cagacatctt     7140

gtatctagta ttacaatatc agaaaactca gcaggttata tgacatatac actttgagat     7200

agtcactcag aggttttcac atacaggatt aaccttgctg cagtgcgtgt gcaagattaa     7260

aaaagatgtc acgggtcact ttgtaatgtc atatcgttgc tgttgataaa taaaggaaat     7320

gttataaata aaa                                                        7333


<210> 810
<211> 1363
<212> DNA
<213> Homo sapiens

<400> 810
cgccgccgcg ggctcaagcg gggcggccgg gccagcgcgg ggcggcggcg ggcaggggcg       60

gcgagtgcgc gggcgctcgc cgccgccctt ctcggcgggc agcgcgcgag gaccaggccg      120

aggaggaagt ggcggcggcg gcggcgggac tgcgcgcccc agctccgatc cccgttccgc      180

gtccccgccg ccgggaggag gtgcccactc gctcgcggcg cgcgccggcc gccagactcg      240

gcctgtgggc gatttcctcc ggacccaggc tccccgcccg aggaggaaga tgcagacctt      300

tctgaaaggg aagagagttg gctactggct gagcgagaag aaaatcaaga agctgaattt      360

ccaggccttc gccgagctgt gcaggaagcg agggatggag gttgtgcagc tgaaccttag      420

ccggccgatc gaggagcagg gccccctgga cgtcatcatc cacaagctga ctgacgtcat      480

ccttgaagcc gaccagaatg atagccagtc cctggagctg gtgcacaggt tccaggagta      540

catcgatgcc caccctgaga ccatcgtcct ggacccgctc cctgccatca gaaccctgct      600

tgaccgctcc aagtcctatg agctcatccg gaagattgag gcctacatgg aagacgacag      660

gatctgctcg ccacccttca tggagctcac gagcctgtgc ggggatgaca ccatgcggct      720

gctggagaag aacggcttga ctttcccatt catttgcaaa accagagtgg ctcatggcac      780

caactctcac gagatggcta tcgtgttcaa ccaggagggc ctgaacgcca tccagccacc      840

ctgcgtggtc cagaatttca tcaaccacaa cgccgtcctg tacaaggtgt tcgtggttgg      900

cgagtcctac accgtggtcc agaggccctc actcaagaac ttctccgcag gcacatcaga      960

ccgtgagtcc atcttcttca acagccacaa cgtgtcaaag ccggagtcgt catcggtcct     1020

gacggagctg gacaagatcg agggcgtgtt cgagcggccg agcgacgagg tcatccggga     1080

gctctcccgg gccctgcggc aggcactggg cgtgtcactc ttcggcatcg acatcatcat     1140

caacaaccag acagggcagc acgccgtcat tgacatcaat gccttcccag gctacgaggg     1200

cgtgagcgag ttcttcacag acctcctgaa ccacatcgcc actgtcctgc agggccagag     1260

cacagccatg gcagccccct caggggagtt ccgcgctggg gatttgtgct gtgatttggg     1320

caaatcattc caggtctttg ggcctccacc cccttgtctc tag                       1363


<210> 811
<211> 852
<212> DNA
<213> Homo sapiens

<400> 811
atgctgcggt gtggacagat gatctttgcc caagccctgg tgtgccggca cctaggccga       60

gattggaggt ggacacaaag gaagaggcag ccagacagct acttcagcgt cctcaacgca      120

ttcatcgaca ggaaggacag ttactactcc attcaccaga tagcgcaaat gggagttggc      180

gaaggcaagt ccataggcca gtggtacggg cccaacactg tcgcccaggt cctgaagaag      240

cttgctgtct tcgatacgtg gagctccttg gcggtccaca ttgcaatgga caacactgtt      300

gtgatggagg aaatcagaag gttgtgcagg accagcgttc cctgtgcagg cgccactgcg      360

tttcctgcag attccgaccg gcactgcaac ggattccctg ccggagctga ggtcaccaac      420

aggccgtcgc catggagacc cctggtactt ctcattcccc tgcgcctggg gctcacggac      480

atcaacgagg cctacgtgga gacgctgaag cactgcttca tgatgcccca gtccctgggc      540

gtcatcggag ggaagcccaa cagcgcccac tacttcatcg gctacgttgg tgaggagctc      600

atctacctgg acccccacac cacgcagcca gccgtggagc ccactgatgg ctgcttcatc      660

ccggacgaga gcttccactg ccagcacccg ccgtgccgca tgagcatcgc ggagcttgac      720

ccgtccatcg ctgtggtact tggggtgggg aagcagggaa ggctggtgcg atctattcct      780

tgggctccac gtccgagttc atggtgcgcc gctgtgctgg gagctgcagt ggtaatgtgt      840

gggacacctt ga                                                          852


<210> 812
<211> 2682
<212> DNA
<213> Homo sapiens

<400> 812
aacgatccca gtgtcggttg cgggatccgc ctcctctcag tttgcccctt tagccctcca       60

cctttccctt ctcctctctc gcatttccgc cagtcggctt acccgctggc cgcctcctga      120

caagcgggag ggatccgcgg tggacccagg gaagcggagg agcctggcgg ccaccccctc      180

ttcctcactt ccctgtactc tcatcgctct cggcctccga cacgaaaagg aagcaaatga      240

gctgatggaa gatctgtttg aaactgtgag taatgatcct caagtgagaa catgggattt      300

tccaagatga gatgggattc tccaacatgg aagatgatgg cccagaagag gaggagcgtg      360

tggctgagcc tcaagctaac tttaacaccc ctcaagctct acggtttgag gaactactgg      420

ccaacctact aaatgaacaa catcagatag cgaaggaact atttgaacag ctgaagatga      480

agaaaccttc agccaaacag cagaaggagg tagagaaggt taaaccccag tgtaaggaag      540

ttcatcagac cctgattctg gacccagcac aaaggaagag actccagcag cagatgcagc      600

agcatgttca gctcttgaca caaatccacc ttcttgccac ctgcaacccc aatctcaatc      660

cggaggccag tagcaccagg atatgtctta aagagctggg aacctttgct caaagctcca      720

tcgcccttca ccatcagtac aaccccaagt ttcagaccct gttccaaccc tgtaacttga      780

tgggagctat gcagctgatt gaagacttca gcacacatgt cagcattgac tgcagccctc      840

ataaaactgt caagaagact gccaatgaat ttccctgttt gccaaagcaa gtggcttgga      900

tcctggccac aagcaaggtt ttcatgtatc cagagttact tccagtgtgt tccctgaagg      960

caaagaatcc ccaggataag atcctcttca ccaaggctga ggacaacaag taccttctaa     1020

cctgcaagac tgcccgccaa ctgacagtga gaatcaagaa cctcaacatg aacagagctc     1080

ctgacaacat cattaaattt tataagaaga ccaaacagct gccagtccta ggaaaatgct     1140

gtgaagagat ccagccacat cagtggaagc cacctataga gagagaagaa caccggctcc     1200

cattctggtt aaaggccagt ctgccatcca tccaggaaga actgcggcac atggctgatg     1260

gtgctagaga ggtaggaaat atgactggaa ccactgagat caactcagat caaggcctag     1320

aaaaagacaa ctcagagttg gggagtgaaa ctcggtaccc actgctattg cctaagggtg     1380

tagtcctgaa actgaagcca gttgccgacc gtttccccaa gaaggcttgg agacagaagc     1440

gttcatcagt cctgaaaccc ctccttatcc aacccagccc ctctctccag cccagcttca     1500

accctgggaa aacaccagcc caatcaactc attcagaagc ccctccgagc aaaatggtgc     1560

tccggattcc tcacccaata cagccagcca ctgttttaca gacagttcca ggtgtccctc     1620

cactgggggt cagtggaggt gagagttttg agtctcctgc agcactgcct gctatgcccc     1680

ctgaggccag gacaagcttc cctctgtctg agtcccagac tttgctctct tctgcccctg     1740

tgcccaaggt aatgatgccc tcccctgcct cttccatgtt tcgaaagcca tatgtgagac     1800

ggagaccctc aaaaagaagg ggagccaggg cctttcgctg tatcaaacct gcccctgtta     1860

tccaccctgc atctgttatc ttcactgttc ctgctaccac tgtgaagatt gtgagccttg     1920

gcggtggctg taacatgatc cagcctgtca atgcggctgt ggcccagagt ccccagacta     1980

ttcccatcgc caccctcttg gttaacccta cttccttccc ctgtccattg aaccagcccc     2040

ttgtggcctc ctctgtctca cccttaattg tttctggcaa ttctgtgaat cttcctatac     2100

catccacccc tgaagataag gcccacatga atgtggacat tgcttgtgct gtggctgatg     2160

gggaaaatgc ctttcagggc ctagaaccca aattagagcc ccaggaacta tctcctctct     2220

ctgctactgt tttccccaaa gtggaacata gcccagggcc tccaccagtc gataaacagt     2280

gccaagaagg attgtcagag aacagtgcct atcgctggac cgttgtgaaa acagaggagg     2340

gaaggcaagc tctggagccg ctccctcagg gcatccagga gtctctaaac aactcttccc     2400

ctggggattt agaggaagtt gtcaagatgg aacctgaaga tgctacagag gaaatcagtg     2460

gatttctttg agctaggaga ataagagtct ggagactggg agccttcact tcggcctccg     2520

attggtggcg catagggtgt aaccaatagg aaacccctaa agggtactta aaccccagat     2580

tttgcaactg gggctcttga gcagcttgct ttagcctgct cccactctgt ggaatatact     2640

tttgcttcaa taaatctgtg cttttattgc ttcattgttt ca                        2682


<210> 813
<211> 1142
<212> DNA
<213> Homo sapiens

<400> 813
acagtgtcat ggaggccgcg gcggtgacgg tcacccggtc ggctacacgg cggcggcggc       60

ggcagctgca ggggctggcg gccccggagg cggggacgca ggaggagcag gaggatcagg      120

agccgcggcc gcggcggcgg cggccgggaa ggagcatcaa agatgaagaa gaagagacag      180

tctttcgaga ggtggtcagt ttttccccgg accccctgcc agttagatat tatgacaagg      240

acaccaccaa accaatcagc ttttacttgt cttcgctgga ggagctcttg gcgtggaagc      300

cccgcttgga ggatggcttt aatgtggccc tggagcccct ggcgtgtcgc cagccccctc      360

tgagcagcca gaggccccgg actttgttgt gtcatgacat gatgggcggg tacctggatg      420

acaggttcat tcagggctcg gtggtgcaga ctccctatgc tttctaccac tggcagtgca      480

tcgacgtctt tgtgtacttc agccaccaca ccgtcaccat tcccccagtg ggctggacca      540

acactgccca caggcatggg gtctgcgtgc tggggacttt catcacggag tggaatgaag      600

ggggaaggct ctgtgaagcc ttcctggccg gggatgagcg ctcgtaccag gcagtggctg      660

accggctggt ccagatcact cagttttttc gttttgatgg ctggctgatc aacatcgaga      720

actcgctgag tctggccgct gtggggaaca tgcctccttt cctgcggtac ctcaccacac      780

agctgcaccg gcaggtccca gggggcctgg tgctctggta tgacagcgtg gtgcaaagtg      840

ggcagctcaa atggcaagac gaactcaacc agcacaacag ggtcttcttt gattcctgcg      900

acggcttctt cactaactat aactggcggg aggagcactt ggagcggatg ctggggcagg      960

ctggggagcg ccgggctgat gtgtacgtgg gcgtggatgt gtttgctcga gggaacgtgg     1020

tcggaggccg attcgacaca gacaagtcgt tggagctgat ccgaaagcat ggcttctccg     1080

tggctttgtt tgcccccggc tgctccgtgt ttcctggcgt tggcaattta ctgtgctgct     1140

ga                                                                    1142


<210> 814
<211> 1503
<212> DNA
<213> Homo sapiens

<400> 814
agccgtgtca agatgagagg gaagcgtaga ccgcagaccc gtgcagctag gcggctggct       60

gctcaggagt ccagcgaggc tgaggacatg agcgtcccca gaggacccat tgcacagtgg      120

gctgatggcg ccatttcccc aaatggccat cggccacagc tcagagcagc cagtggagaa      180

gacagcactg aggaggccct ggcagctgcc gctgcacctt gggaaggtgg tcctgtgcct      240

ggagtggaca caagcccctt tgcaaagtct ctgggtcatt ccagagggga ggctgacctt      300

tttgattctg gggacatttt ttccacgggc actggatctc agtccgtgga gagaacaaaa      360

cccaaggcaa agatagcaga gaatcctgcc aacccaccag tgggtggtaa agcaaagagc      420

cccatgtttc ctgctctagg cgaggccagc agtgatgatg atctctttca gtctgctaaa      480

ccaaaaccag caaagaaaac aaatcccttt cctctcctgg aagatgagga tgacctcttt      540

acagatcaga aagtcaagaa gaatgagaca aaatccagta gtcagcagga tgtcatatta      600

acaacacaag atatttttga ggatgatata tttgctacgg aagcaattaa accctctcag      660

aaaaccagag agaaggagaa aacattggaa tctaatttat ttgatgataa cattgatatc      720

tttgctgact taactgtaaa accaaaagaa aagtccaaaa agaaagtgga agccaagtct      780

atatttgatg atgatatgga tgacatcttc tccactggta tccaggctaa gacaaccaaa      840

ccaaaaagcc gatctgcaca ggccgcacct gaaccaagat ttgaacacaa ggtgtccaac      900

atctttgatg atcccctgaa tgcctttgga ggccagtaga gcacacaggg tatccacatg      960

ttaccctgca gctacattgt tgagttagtg atgatattgt atatgctcat ggtcttaact     1020

ggattacaaa aagcaaatac tagaacagct agctcatctt ttacccaatg tacttagtat     1080

ttttctgcac tggtttaatc atgcttaata ctacaaaaca aaaataaata tttcacagtg     1140

gttggtttgt tttgttttta aaccacagtt tgatttagtt agccttgctg gggccataat     1200

atgcttcagg gtgtgtaaaa gaagaaatct ctttgtggct ttcatgggca gggaatctca     1260

gagatagcaa atgccacctg accagaagtc tttgttatat ggatgggaac cctaacttag     1320

ggcttgggca ggggaaagag aaagaagatg agagattata cttcatgagt cttagcaata     1380

tgggagcagg ttttcactga attctgaggg tgcctctgca tgtcctccaa ggcaaagttt     1440

ggcaaactgt ggccccccca ctgtcatatt ttgttaataa aattttattg gaacacaatc     1500

aca                                                                   1503


<210> 815
<211> 1842
<212> DNA
<213> Homo sapiens

<400> 815
tcggggtgag ggccgtccgc ggcctcgctt tcgcctcctc cgagccgggc cggcgatggc       60

cgcagctgtg aggcgagcag aagaatagaa ggaaggtgat aggatgtgat gatagaattt      120

gtgatagcca agcaacaact tttcctaatt cggcatgtta aaaaataagg gtcactcatc      180

taagaaagat aacttggcag tcaatgcagt tgctttacaa gatcacattt tacatgatct      240

tcaacttcga aatctttcag ttgcagatca ttctaagaca caagtacaaa agaaagagaa      300

caaatctcta aaaagagata caaaggcaat aatagatact ggacttaaaa aaactacaca      360

gtgccccaaa ctagaagact cagaaaaaga atatgttctt gatcccaaac cgccgccgtt      420

gactttggca cagaagttgg gcctcattgg gcctccacca cctccactgt catcagatga      480

atgggagaag gtgaaacagc gctctctcct gcaaggggac tccgtgcaac catgccccat      540

ctgtaaagaa gaattcgagc ttcgtcctca ggtgctgctt tcatgctccc atgtgttcca      600

caaagcatgt cttcaggctt ttgaaaagtt cacaaataag aaaacctgtc ctctctgtag      660

aaagaaccag tatcaaaccc gagtgataca cgatggggcc cgcctgttca gaatcaagtg      720

tgtgaccaga atccaagcct actggagagg atgtgttgtt agaaagtggt acagaaacct      780

gaggaaaaca gtacctccca cagatgccaa gttaagaaaa aaattctttg aaaaaaagtt      840

cacagaaatc agccaccgca tcctgtgctc atacaacacc aacattgaag agctctttgc      900

agaaatcgat cagtgcttgg ccataaatcg aagtgttctt cagcagttgg aagaaaaatg      960

tggccatgag atcacagaag aggaatggga gaaaatccaa gtgcagaatg aaacttccgc     1020

atgtttcgaa gacccatgtc tcggggcaca tggttcgcat ttcagtttaa gtaactttct     1080

gctgtgatga aactaacccg cgtggcctct tcccgtcctg tgtgccgcag gctctgcgcc     1140

gggagaccca cgagtgctcc atctgcctgg cccctctctc cgctgctggc ggtcagcgcg     1200

tgggtgcagg caggcgttcc agagagatgg ccctcctgtc ctgctcacat gtgttccacc     1260

atgcgtgtct gctggcacta gaggagttct ccgtgggaga caggcctcct ttccatgcct     1320

gtcctctctg ccgctcctgc taccagaaga agattcttga atgttgaatt catagtcaag     1380

gaaagttagg taattctgag gaaaaaagtt taccatcatt ttggatgaac tgcatgagtt     1440

ctgggttaag tactacaatg taatctgttt cccagggaaa taagctattg gtagttgtag     1500

gaaatcttag tatattttaa aagctgacat cccacctaat tttaatcttt ggtctctaaa     1560

aagtaaattt caaatttatg agtttaatca cttcaaatat gaatagcaaa aaatgagagc     1620

ttgcttactt ctaaaaattg aggttaagat atagctagtg tctgaacgac actccttaaa     1680

gtaagttcca aatgtaaaac actccttaag ttccaaatgt tttccgctaa tagtctgtcc     1740

taaagccttt gccattccta atactcgttt tgtaataatt gctgtatttc tgtgtaataa     1800

aatataaaaa taaaatattc agtggtattc aacatcaaaa aa                        1842


<210> 816
<211> 3635
<212> DNA
<213> Homo sapiens

<400> 816
aaggaggagt gcactggccg ggatcggtgc agcgctcaca ctcactcaca gtcactctct       60

ctgagcgcgt ctcgctcgct ctcatacacg cccggagccc aggagcgctc aggatcccga      120

gcgccgcgaa aaagttcccc cggcttttgc tggagactca tcgctttggg aagtgcattt      180

gcttcgtggc tccgccgagc ctgctgaatc ctgtcctcgc ggctcgggac cccgggatcg      240

ctgaccgctg ccgccgccgc ctctgcctcc cggactatcg gcagcctcgg caacaatagt      300

ggcggccgcc cccagcgagg ctccgggagc ccttgcctgc gggggtccgg ggactcgagc      360

cggcctccgc ctcccggacg cacagccagc gtggtccccg cgtgcaacgc gagcgccggg      420

gagtggctcc tgctttgccc ctcgtggggg ccgagccaag accagtctgc aaactccatc      480

ccgccggctg gaagaagtcg cggagccggc accaaacccg cagcgtcttc ccgcgcggat      540

cccgggactt aaaaagccgg ggccaccccg gcccaggacg ggatgcgggt cggtccggtg      600

cgctctgcca tgagcggcgc ctcgcagccc cgcggcccgg ccctgctctt cccagccacc      660

cgaggcgtcc cggccaaacg cctgctggac gccgacgacg cggcggctgt ggcggccaag      720

tgcccgcgcc tctccgagtg ctccagcccc ccggactacc tcagcccccc cggctcgccc      780

tgcagcccgc agcccccgcc tgccgctccg ggggccggcg gaggctccgg gagcgcgccg      840

gggcccagcc gcatcgccga ctacctgctg ctgcccctag ccgagcgcga gcatgtgtcc      900

cgggcgctgt gcatccacac tggacgcgag ctgcgctgca aggtgtttcc cattaaacac      960

taccaggaca aaatcaggcc ttacatccag ctgccatcgc acagcaacat tactggcatt     1020

gtggaagtga tccttgggga aaccaaggcc tatgtcttct ttgagaagga ctttggggac     1080

atgcactcct atgtgcgaag ccggaagagg ctgcgggaag aggaagccgc ccggctcttc     1140

aagcagattg tctccgccgt cgcccactgc caccagtcag ccatcgtgct gggggacctg     1200

aagcttagga agttcgtctt ctccacggag gagagaaccc agcttagact agaaagtcta     1260

gaagacacac acataatgaa gggggaagat gatgctttgt cagacaaaca tggctgccca     1320

gcctacgtga gccctgagat cctcaacacc actgggacct actccggaaa ggctgcggac     1380

gtttggagcc tgggggtgat gctctacacc cttctggttg gacgataccc cttccatgac     1440

tcagacccca gtgccctttt ctccaaaatt cggcgtggac agttctgcat tcctgagcac     1500

atttccccca aagccaggtg cctcattcgc agcctcttga gacgggagcc ctccgagaga     1560

ctcactgccc ccgagatcct actgcacccc tggtttgagt ccgtcttgga acccgggtac     1620

atcgactcag aaataggaac ttcagaccag attgttccag agtaccagga ggacagtgac     1680

attagttcct tcttctgcta atccccaaaa cctcagaaac ctcataattc ttaacacctg     1740

gcatttccat ttctaaagat ggacaggccc tttggcgtgg taccaaccag ataatgactg     1800

catcaggatg aaagctgctg aactcggcat ggcgcctcct cttctctgtt gggatgagtg     1860

actttattga tttgagcagc atatgctgtg attggctgcc ctgcaaattt gtttccctta     1920

aggaaccctc accaactatc tctgctggat ttgggagttc cgcatctttt gtggagggca     1980

gagtatggac atcttacacc cggtggtcaa gtgtgtaata aacttgagca ttcgaatggg     2040

agaaaaagca aatcgcacaa tgacatattt tgagtaataa ccgtattttt cacagggtga     2100

caaattgggc caataaatct gccatctttg aactcatctt tggtggctag actgctacgg     2160

cagcttctct gatgggaaag ttcctttttt ggcttaacac tcaccctttc ttcacactca     2220

catttaccaa tgactctgct ccgtttttgg agcagactgt tttaagttgc tcaggagcct     2280

gatggaacca tgaaccgaga ctcttctctg tttcctgcca agacctcatc tgcactaatg     2340

ccttctccct gaccttgaca cttccccctt tagctataaa agcacttacc agccgaacgt     2400

ggaacagtat cacaaaagat tccatctccc aacgatttca gaactctgag ctcagagaga     2460

ctccagattt taaaaaataa tttgagtgct tggaaactat tagcttttta agttccttcc     2520

aaatatgtta gtacctaccc tttacttttt ccccaagacc atctcagggt ggagcattct     2580

gtctaagaga agaaagataa ggaggctccc acccacctct cccaagagca gacattaaac     2640

atctttgtgc tttgaagaga gtgaattttg gatagtcttg tgattctcag actaacttcc     2700

agaattatac tttaacccct cccagatatg gtccgccttt ggcattgtgt gtacatctgc     2760

agttttgcat ggtgggttgt taatatttca aatgtgtggt ttatgaatac gtctgtataa     2820

tcggcttctg gagtgaaaca gcaaacccca aatcttcaaa gttggaagga actttaaaaa     2880

tcatccggtc caatctcttt cctctttctg ccacctccca aggcagaaat cccctcttca     2940

gcttcttttg taggtgggaa tccagcctct gttagatatg tccagagatg gaaactcact     3000

cccctacaaa agatggagct taatggagaa attgcaactt tcattaaaaa acaaattcag     3060

atgaaatatc agtaactgtc ttggacagtg ctgaaatcag gtggttaaac gggtaaacaa     3120

aatatactgt attttgagaa atggcacaaa aacaggcagt catctttaag ggctatgcct     3180

aggcaaacta ctaacatgca ttgtgagaat gccgtgtata cctcacgtac tgtgtacttt     3240

gtacatatat tttacctttt atacctatgt tcgattttgt tttgttttgt tttgttctgg     3300

ctttgaggct tgttttgttg tctgtgtctg tctgaataac ctgcgtgtct aaaaccacgt     3360

gaaatgtgaa tgattattgg caatattacc ttgacagaat catgggactt tgagaagagg     3420

gaggacagag gcctctgtcg cactaacgct ctcgtggttg ctcgactgtt gtatctgtga     3480

tacattatcc gactaaggac tctgggctgg cagggccttc tgccgggaaa gctagaaaca     3540

ctaggttctt cctgtacata cgtgtatata tgtgaacagt gagatggccg tttctgactt     3600

gtagagaaat tttaataaac ctggtttcgt aaata                                3635


<210> 817
<211> 4723
<212> DNA
<213> Homo sapiens

<400> 817
actgccgctg ccgcggctac ctgcggttca tctccgcaca ttccacacgc ggcccaaacg       60

gtctctctct ctctctctca aacaccgcct ttccgtcttt gttttatctt gagtagctta      120

gaaagattgg agaagaaagc ttacgtggaa tgaaaatcaa cttttatgga tattttgagg      180

actaaaagaa taaatagggc gtccgtactg tagcgaaagt gcgactaagg ttaggcatct      240

ggatttcccc cgtagccctc tttcaccccc cccccccggc cattaccgaa gcggatgaaa      300

acaaacacta acgatggcgg cgccgggaag cgaccggctg ctgggcttaa ggcgggagtg      360

accgcttaac cagtgaggga agcactgaag agcgccagtc gacgtgggtg cgacaactcg      420

cggagtctta ggagcaaaac gtctggggcc tgcgagccag gacccttctg aagccttagg      480

tgtctatcgg cgacgtgtac ggtcactgca gctccggagc gcggaaccct cagccaggag      540

gcgcggctgg tcggtcccag gtcccggcct ccgtaatgag agcccggaac cactctttgt      600

gccgcagctt cgcagcatct tggactcaag tgattctcct gcctcagcct cctgagtagc      660

tgggactaca gattcctata ggcaatggaa actgatctca attcccagga cagaaaggac      720

ctggacaagt ttattaaatt ttttgccctc aagactgtcc aagtgattgt ccaggctcgg      780

cttggtgaaa agatttgcac tcgttcatca tcttctccaa cgggttcaga ttggttcaac      840

ttagcaatca aagacatccc agaggttaca catgaagcaa agaaggcact ggcaggacag      900

ctgcctgcag tcgggaggtc catgtgtgtg gagatttcac ttaagacttc tgagggagat      960

tccatggagc tggaaatatg gtgtcttgaa atgaatgaaa agtgtgataa agaaatcaaa     1020

gtttcctaca cggtgtacaa cagactgtca ttgctgctga agtcccttct tgctataact     1080

agggtgacac cagcctatag gctctccagg aaacaagggc atgaatatgt catattatac     1140

aggatatatt ttggagaagt tcagctgagt ggcttaggag aaggcttcca gacagttcgt     1200

gttgggacag tgggcacccc tgtgggcacc atcactcttt cttgtgctta cagaattaac     1260

ttggcattca tgtctaccag gcaatttgag aggaccccac ctatcatggg gattattatt     1320

gatcactttg tggaccgtcc ctatcccagc tcctctccca tgcacccctg caattacaga     1380

actgctggtg aggacactgg agtaatatac ccgtctgtag aagactctca agaagtgtgt     1440

accacctctt tttccacctc cccaccatcc cagctctcaa gctctcgcct ttcctatcag     1500

cctgctgccc tgggcgttgg atcagctgac ctggcttatc cagtagtgtt tgctgctggc     1560

ttaaatgcta cacaccctca ccagctgatg gttcctggga aggaaggtgg ggtacccctt     1620

gctcccaacc agcctgtcca tggtacccag gctgaccagg agagactggc aacctgcacc     1680

ccttctgaca gaacccactg tgctgccaca ccctccagta gtgaggatac tgaaaccgta     1740

tcaaacagca gtgagggacg ggcctcccct cacgatgtct tggagaccat ctttgtccga     1800

aaagtggggg cttttgtcaa caaacccatt aaccaggtga ccctgacgag tttggatata     1860

ccctttgcca tgtttgctcc caagaatttg gagctggagg ataccgatcc aatggtgaat     1920

cctccagatt ccccagagac tgaatctcct ctccagggca gcctgcactc agatggctcc     1980

agcgggggca gcagtggcaa tacccatgat gactttgtta tgatagactt taaaccagct     2040

ttttctaaag atgacattct tccgatggac ctggggacct tctatcggga gtttcagaac     2100

ccacctcagc tgagcagcct ctccatagat attggagcac agtccatggc tgaagacttg     2160

gactcattac cagagaagct ggctgtgcat gagaagaatg tccgcgagtt tgatgccttt     2220

gtggaaaccc tgcagtaaaa gtatccttga gtcccagcag cacccccttt ttgtggcccc     2280

agggcataag cagcctccca tgcatcagct gctcccaccc ctcatcctgc tctgagccag     2340

gtggaaggga ggctggcttc tcccatgggg acccagaagt ccctactctt ggacctcctg     2400

gagactccgt ggcggcagtc aagcccagtg cccagttgga gaagactcac gtgctggcct     2460

tggagatggg aagaaccttc gtacgaaaaa gccctcagca gggccatctg tgtgccctgc     2520

ccatcaccaa ctgcttccca agggtgtcat cctgttcctc ctgctgccgg cctcctgcct     2580

gggcctgcct tgcagctggc cccttccctg cctgctgtca ccatccactg tttgacattc     2640

cagctggtgg ccaagagatt ggtgtggagt cgcagaaaga ggaaggagac agtgccagga     2700

ggaagaagga aggagtccct tagctctctt cattgtcccc tttacttcct gctatcttct     2760

tctcctcttc ttctctctct tgcctctatg cctgtatttc tggcaatatg acaggcctgc     2820

ctacccaaga tcagaactcc aaaaccactc ccacccctga aggtcgggag ggtctgagca     2880

gccctggtgg ctgcctgtgc tcaggtcctc agctccatgg gaaataaaaa tggcaccctg     2940

aatctctagg attttgtcac ttggagtcac agcaaagttc tcttcctctt gtccccccgt     3000

tgctgctcct tggttataga acatggtaaa tatttattac tttcagagaa accagatatt     3060

ttatagagga aatatgtttg aggtgagttg tttttcactt ggagaaggcg gagggctctt     3120

cctgggacgg agacctcctc ctccggaggt tattgagaat ccgggctgct gctttgagga     3180

tcttcccacc atacagacag cgagatccaa gaagagggct ggccgggggc aaagtcacct     3240

cccagtgtgg ctgcactgga actgactaaa ggctttacct tggatagttg cgtattcctg     3300

gtgagagcct tacatctccc acagtttctg cagagtgact gactccattc tggcagccca     3360

ggaagtcctg ggtgctaaat gtgatggcca catgtagtgg ttaggggatg ttgtgtgtgt     3420

cccccaactg cctgggtact tgttcctgat ccctggggct gtcctgtgga gcttttcctc     3480

ctgcttgggc ctagctacca tctccctcta atcccaggtt ctctacactg ccctggggtt     3540

taccagctgg attggcttct ggttgagaaa tcaaagctgg gcgtatgatt gacttaaccc     3600

ttcaggtatt gttacttgaa taagtcaagt gcctagcctc acccacctat gatctgtcct     3660

ttcccagcct cgctggtagt cctggtcaag gagatctagg tctactccat tcctcctggc     3720

ccacctgggg cattcactgg cagcagctgt gcttcagtgg agcaggtggt tctcagctgc     3780

ttgttagtat actgcatgtg acactgttcc cacatacaag gctgacttct gaggattgga     3840

gcaggctctg gcggggacca gagctctgcg tgctgctgct gccaccaaga agtgttagca     3900

gaagcagtag cagccaactg gccctcctga ctttggccca gagcacatgc gtggcttgct     3960

gaacccaggc tcaggtttat ccccaaggcc ccagctttga gaagggggaa ggcccctggt     4020

aagttattga tgcccccata tttcagctac tgctctcttt ccaaggcctt gcatggaaag     4080

gcctagccat tgtctgaggc agcaatcttt ggcatctaca ggtggcagca gcctttcacc     4140

agggctccat ctgtgaagag tctcagccat gactttgagc tgagcttggg agaagtaaag     4200

caactgttaa ggccagccct tgcccctcag acctgccatg aaaggaatga gccctagact     4260

gactcctgca gcacccccgg gacaggctgg gaccagctgt ttgtctccag gtgtcagagt     4320

ccctcctcct cctccaacct ctccaaccta ctttgtttgg aaataccgag ctacacttca     4380

aaatgtattc aagggatttc caataaattt ttttctgtac tttacagcct cctgtcctgt     4440

aggttgtctg aagacctcgt aaccccttcc ccacccctgc cccagtgcag gtctgggaaa     4500

ggggagagtg gtgcgttgtg aagcgcagaa agacctcaag tgtctgggca agcctgtttt     4560

gagtcgggtg tggcctctta ggggctgtat accctggggt ttcctgggtc aggaaacttc     4620

ttagtatttc tctttccctg gtcccctatc aggggcttga atttgaatat tcagttggag     4680

aatgcattta aaatacaccc atagtaaaat ctccataaaa tgc                       4723


<210> 818
<211> 2238
<212> DNA
<213> Homo sapiens

<400> 818
acacgccgcg ctgaggcccg cgggcccgtc atggaggcgc ccaccgtgga gacgcccccc       60

gacccctcgc ccccttcggc cccggcccct gccctggttc cgttgcgcgc cccggatgtg      120

gcgcggctgc gcgaggagca ggaaaaggaa gaaggtagat aatgactata atgcccttcg      180

agaaagactc agcaccttgc ctgataaatt gtcttataat ataatggtac catttggccc      240

ttttgccttc atgccaggaa aacttgtcca tactaatgaa gtcactgttt tactggggga      300

caactggttt gcaaagtgct cagcaaagca ggctgtaggt ttagttgagc accggaaaga      360

acatgtaaga aaaacaatag atgacttaaa aaaagtgatg aaaaattttg aatccagagt      420

tgaattcaca gaagatttgc agaaaatgag cgatgctgca ggtgatattg ttgacatacg      480

agaagaaatt aaatgtgact tcgaatttaa agcaaaacac cgaattgctc ataaaccgca      540

ttccaaacca aaaacttcag atatttttga agcagatatt gcaaatgatg tgaaatccaa      600

ggatttgcta gctgataaag aactgtgggc tcgacttgaa gaactagaga gacaggaaga      660

attgctgggt gaacttgata gtaagcctga tactgtgatt gcaaatggag aagatacgac      720

atcttctgaa gaggaaaagg aagatcgtaa cacaaatgtg aatgcgatgc atcaagtaac      780

agactctcat actccttgtc ataaggatgt tgcaagttca gaaccattca gtggtcaagt      840

gaatagtcag ttgaactgtt cagtgaatgg ttccagttct taccacagtg atgatgatga      900

tgatgatgat gatgacgacg acgacgacaa cattgacgac gatgatggtg ataacgacca      960

tgaggcttta ggggttggag ataattctat accaacaata tatttttcac atactgttga     1020

gcctaagagg gtccgaataa atactggaaa gaataccact ttaaaattca gtgaaaagaa     1080

agaagaagcc aaacgtaaac gaaagaacag cactggcagt ggccactctg cccaggagct     1140

gccgaccatc aggacgcctg cagacattta cagagccttt gttgatgttg tgaatggaga     1200

atatgtccct cgcaaatcca tcctgaagtc tcgaagtaga gagaatagtg tgtgtagcga     1260

cactagtgaa agcagtgctg ctgaatttga tgataggcgg ggagttttga ggagtatcag     1320

ctgcgaagaa gccacttgca gtgacaccag tgagagcatt ttggaagagg aaccacaaga     1380

aaatcaaaag aaacttttgc ccttatcagt aacacctgag gctttttctg gaactgttat     1440

agaaaaagaa tttgtatcac cttccttaac accaccccca gccattgctc atcccgcact     1500

acccactatt ccagaacgaa aggaagttct gttggaagca tctgaagaaa ctggaaagag     1560

ggtttcaaag tttaaagctg ccagattgca acagaaagac taggccctgt ctaggaaatg     1620

ggaatttaca tcctaaaacc tagttgttca tttgtttaga gtatctatag caaaataggt     1680

tacatgtagt ttgaaataag gtatcctgag ttactttggc aacaagttct tttaccctta     1740

cccgtggtat ttgaaaaaaa tcaaggtaac tgtctgaata ctttaatatc agcttgtttt     1800

gtgaattctc tgaatactgt caacactctt atctaagttt gcctttatga tgcagtggca     1860

gcattttgaa ttacttttca aagaatactg ttcatatgca ttgtttttgt gtttcaaact     1920

aaatacaggc agttttgtgc cagctgtgat attgtgcata ccatatggac cattttaaag     1980

aaaattttaa aatttcaaat agattcaaca attacattac ttgctttcac attttaaagg     2040

cactttaaaa aaatctactt ctcttgtagg ttttgcggct agttggctat tcaagaaacc     2100

tcgcccctct gaatgtcata ctgtaatctt taaggaagaa agctacatga attaattgta     2160

ctctatggga aaatttcttt ggaaagatat tttgtaaaac ttttttttcc aagtaaaaac     2220

tttatgaaac ttggtctc                                                   2238


<210> 819
<211> 1662
<212> DNA
<213> Homo sapiens

<400> 819
gccctcgcgc tgtcgccgcc acagtctgcg acgggacccg gcgtgcccat gtgtcaggtg       60

ggcgaggact acggggagcc ggcgcctgag gagccgcccc cggcgccgcg gcccagccgt      120

gagcagaagt gtgtgaagtg caaggaagcg cagcccgttg tggtgatacg agccggagat      180

gccttctgca gggactgttt caaggccttc tacgtccaca agttcagagc catgctgggc      240

aagaaccggc tcatctttcc aggcgagaag gtgctcttgg cgtggtctgg ggggccttcg      300

tccagctcca tggtctggca ggttcttgag ggcctgagcc aagattctgc caaaagactg      360

cgctttgtgg caggagtcat ctttgttgac gagggagcag cctgtggcca gagcctagag      420

gagagatcaa agaccctggc cgaagtgaag cccattctgc aagcaactgg gttcccatgg      480

catgtggtgg ccttagagga ggtgttcagc ctgccaccgt cggtgctttg gtgctctgcc      540

caggagctgg tgggatccga gggggcctac aaggcggccg tggacagctt cctccagcag      600

cagcatgtgc tgggggccgg gggtggtcct ggcccgactc aaggggagga acagccaccc      660

cagcccccgc tggaccccca gaacctggca agaccgcctg cccctgccca gactgaggct      720

ctttcccaac tgttctgctc agtgaggaca ctgactgcca aggaggagct tctgcagacc      780

ctgcggaccc acctgatcct ccacatggcc cgagcccacg gctactccaa ggtcatgact      840

ggggacagct gcacacgctt ggctatcaag ctcatgacca acctggcgct gggtcgaggg      900

gccttcctgg cctgggatac gggcttctcg gatgagcggc acggggacgt ggtggtggtg      960

cggcccatgc gggaccacac cctgaaggag gtcgctttct acaaccgcct gttctccgtt     1020

ccttctgtct tcacaccagc cgtcgacacc aaggcccctg aaaaggccag catccaccgg     1080

ctgatggagg ccttcatcct caggctgcag acccagttcc cctccactgt cagcactgtg     1140

tacaggacaa gtgagaagct ggtgaagggc ccccgggatg gccctgctgc tggcgactcc     1200

ggcccccgct gcctcctctg catgtgtgcc ctggacgtcg acgccgctga cagtgccacg     1260

gcttttgggg ctcagacctc ctcgcgtctc tcccagatgc agtcacccat ccccctgact     1320

gagacccgga cacccccggg gccctgctgt tctccagggg tgggctgggc ccagcgctgt     1380

ggccaggggg cctgcaggag ggaggacccc caagcctgca ttgaggagca gctgtgctac     1440

agctgccgcg tgaacatgaa ggacttgggc ctggggcttg caggagatcc gggactgtct     1500

gattgaggac agtgacgacg aggcgggcca gagctgagcg tgaggacgtg cttgccggga     1560

cagcaggcag tggccacctg gtacaccaca ctggagccgg aaggcaagga cgggggactg     1620

gcctctgatt gtccatttgt ataaataaaa cattttttaa tt                        1662


<210> 820
<211> 1670
<212> DNA
<213> Homo sapiens

<400> 820
aagaaggcac tccattctgg ctttcacaaa tacagctctg caacgcgttt gccctgatac       60

catgtctctt cgactttcca gtgcatccag gaggtcctgt cctcgtccca ccactggatc      120

actcagactc tatggtgggg gaaccagctt tggtactgga aattcttgtg gcatttcagg      180

gattggaagt ggcttctcta gtgccttcgg aggcagctca tcgggaggaa acacaggggg      240

aggtaatccc tgtgctggct tcactgtgaa tgagcggggg ctcctttctg gcaatgagaa      300

ggtgaccatg cagaacctca atgaccgcct ggcatcctac ctggacagtg tgcatgctct      360

ggaggaggcc aacgctgacc tggagcagaa gatcaagggc tggtatgaga aatttgggcc      420

tggctcttgc cgtggtcttg atcatgacta tagcagatat ttcccaataa ttgatgacct      480

taaaaatcag atcatcgcat ccaccaccag caatgctaat gctgttctgc agatcgataa      540

tgccaggctt acagctgatg atttcagact caagtatgaa aatgagctgg ctcttcacca      600

gagtgtagag gctgatgtca atgggttacg aagagttttg gatgaaataa ccctgtgcag      660

aacagatctg gagattcagt atgaaaccct gagtgaggag atgacttacc tcaaaaagaa      720

ccataaagag gaaatgcaag ttctgcagtg cgcagctgga ggcaacgtga acgtggagat      780

gaacgcagcc cccggggtgg acctcacagt tctgctgaac aacatgcgag ctgagtacga      840

agcccttgca gagcagaacc gcagggacgc ggaggcctgg ttcaacgaga agagcgcctc      900

cctgcagcag cagatctctg aggatgtcgg agccacaacc tcagcccgga atgagctgac      960

tgaaatgaag cgcactcttc aaaccctgga aattgaactt cagtctctcc tagccacgaa     1020

acactccctg gagtgctcct tgacagagac cgagagcaac tactgtgcgc agctggcgca     1080

gatccaggct cagatcgggg ccctggagga gcagctgcac caggtcagaa ccgagaccga     1140

gggccagaag ctggagtatg agcagctcct ggacatcaag ctccacctgg aaaaagaaat     1200

tgagacctac tgtctcctta taggaggaga tgatggagcc tgtaagtctg ggggttacaa     1260

gtctaaagat tatggatctg gaaatgtggg aagtcaagtc aaagacccag ccaaagccat     1320

agtggttaag aaagttcttg aggaggtaga ccaacgcagc aaaatactta ccaccaggct     1380

ccactccctg gaagagaaat ctcaaagcaa ttaatttgag atgcaacaga gaacgtatgc     1440

cacatagccc ctgcgaagaa aaggcattat gtatctgtcc agaaaaatgt gcatgtctaa     1500

gaaaaatgtc taacctgttg tctttctgtt actttctttc tgggcaatca atgacagcat     1560

ctccccattc atctagaaga atgccacaca caaatatgac tcatttgatt atcctacaga     1620

aatctgttgt caattctttg tattcaataa acctcttctt tagcaagtta                1670


<210> 821
<211> 2679
<212> DNA
<213> Homo sapiens

<400> 821
atggaccagc cagaggcccc ctgctccagc acggggccgc gcctcgcggt ggcccgcgag       60

ctgctcctgg ctgcgctgga ggaactgagc caagagcagc tgaagcgctt ccgccacaag      120

ctgcgcgacg tgggcccgga cggacgcagc atcccgtggg ggcggctgga gcgcgcggac      180

gccgtggacc tcgcggagca gctggcccag ttctacggcc cggagcctgc cctggaggtg      240

gcccgcaaga ccctcaagag ggcggacgcg cgcgacgtgg cggcgcagct ccaggagcgg      300

cggctgcagc ggctcgggct cggctccggg acgctgctct ccgtgtccga gtacaagaag      360

aagtaccggg agcacgtgct gcagctgcac gctcgggtga aggagaggaa cgcccgctcc      420

gtgaagatca ccaagcgctt caccaagctg ctcatcgcgc ccgagagcgc cgccccggag      480

gaggcgatgg ggcccgcgga agagcctgag ccggggcgcg cgcggcgctc ggacacgcac      540

actttcaacc gcctcttccg ccgcgacgag gagggccggc ggccgctgac cgtggtgctg      600

cagggcccgg cgggcatcgg caagaccatg gcggccaaaa agatcctgta cgactgggcg      660

gcgggcaagc tgtaccaggg ccaggtggac ttcgccttct tcatgccctg cggcgagctg      720

ctggagaggc cgggcacgcg cagcctggct gacctgatcc tggaccagtg ccccgaccgc      780

ggcgcgccgg tgccgcagat gctggcccag ccgcagcggc tgctcttcat cctggacggc      840

gcggacgagc tgccggcgct ggggggcccc gaggccgcgc cctgcacaga ccccttcgag      900

gcggcgagcg gcgcgcgggt gctaggcggg ctgctgagca aggcgctgct gcccacggcc      960

ctcctgctgg tgaccacgcg cgccgccgcc cccgggaggc tgcagggccg cctgtgttcc     1020

ccgcagtgcg ccgaggtgcg cggcttctcc gacaaggaca agaagaagta tttctacaag     1080

tatttccggg atgagaggag ggccgagcgc gcctaccgct tcgtgaagga gaacgagacg     1140

ctgttcgcgc tgtgcttcgt gcccttcgtg tgctggatcg tgtgcaccgt gctgcgccag     1200

cagctggagc tcggtcggga cctgtcgcgc acgtccaaga ccaccacgtc agtgtacctg     1260

cttttcatca ccagcgttct gagctcggct ccggtagccg acgggccccg gttgcagggc     1320

gacctgcgca atctgtgccg cctggcccgc gagggcgtcc tcggacgcag ggcgcagttt     1380

gccgagaagg aactggagca actggagctt cgtggctcca aagtgcagac gctgtttctc     1440

agcaaaaagg agctgccggg cgtgctggag acagaggtca cctaccagtt catcgaccag     1500

agcttccagg agttcctcgc ggcactgtcc tacctgctgg aggacggcgg ggtgcccagg     1560

accgcggctg gcggcgttgg gacactcctg cgtggggacg cccagccgca cagccacttg     1620

gtgctcacca cgcgcttcct cttcggactg ctgagcgcgg agcggatgcg cgacatcgag     1680

cgccacttcg gctgcatggt ttcagagcgt gtgaagcagg aggccctgcg gtgggtgcag     1740

ggacagggac agggctgccc cggagtggca ccagaggtga ccgagggggc caaagggctc     1800

gaggacaccg aagagccaga ggaggaggag gagggagagg agcccaacta cccactggag     1860

ttgctgtact gcctgtacga gacgcaggag gacgcgtttg tgcgccaagc cctgtgccgg     1920

ttcccggagc tggcgctgca gcgagtgcgc ttctgccgca tggacgtggc tgttctgagc     1980

tactgcgtga ggtgctgccc tgctggacag gcactgcggc tgatcagctg cagattggtt     2040

gctgcgcagg agaagaagaa gaagagcctg gggaagcggc tccaggccag cctgggtggc     2100

ggcagcagtt ctcaaggcac cacaaaacaa ctgccagcct cccttcttca tccactcttt     2160

caggcaatga ctgacccact gtgccatctg agcagcctca cgctgtccca ctgcaaactc     2220

cctgacgcgg tctgccgaga cctttctgag gccctgaggg cagcccccgc actgacggag     2280

ctgggcctcc tccacaacag gctcagtgag gcgggactgc gtatgctgag tgagggccta     2340

gcctggccgc agtgcagggt gcagacggtc agggtacagc tgcctgaccc ccagcgaggg     2400

ctccagtacc tggtgggtat gcttcggcag agccctgccc tgaccaccct ggatctcagc     2460

ggctgccaac tgcccgcccc catggtgacc tacctgtgtg cagtcctgca gcaccaggga     2520

tgcggcctgc agaccctcag tctggcctct gtggagctga gcgagcagtc actacaggag     2580

cttcaggctg tgaagagagc aaagccggat ctggtcatca cacacccagc gctggacggc     2640

cacccacaac ctcccaagga actcatctcg accttctga                            2679


<210> 822
<211> 2347
<212> DNA
<213> Homo sapiens

<400> 822
gcgggcaggc gactcctgtc ccgggtggag gcggcggagc cggagccggg ggagggggca       60

gcggctgtct cacggaccac ggcggcgccc gcagctcctc accgaaacaa ggagaccagt      120

gctggtccag tggctgtgat gggaaaagat tattacaaga ttcttgggat cccatcgggg      180

gccaacgagg atgagatcaa gaaagcctac cggaagatgg ccttgaagta ccacccagac      240

aagaataaag aacccaacgc tgaggagaag tttaaggaga ttgcagaggc ctatgatgtg      300

ctaagtgacc ccaagaaacg gggcctgtat gaccagtatg gggaggaagg cctgaagacc      360

ggcggtggca catcaggtgg ctccagtggc tcctttcact acacctttca tggggacccc      420

catgccacct ttgcctcctt ctttggtggc tccaacccct tcgatatctt ctttgccagc      480

agccgctcca ctcggccctt cagtggcttt gacccagatg acatggatgt ggatgaagat      540

gaggacccat ttggcgcttt cggccgtttt ggcttcaatg ggctgagtag gggtccaagg      600

cgagccccag aaccactgta ccctcggcgc aaggtgcagg accccccagt ggtgcacgag      660

ctgcgggtgt ccctggagga gatctaccat ggctccacca agcgcatgaa gatcacaagg      720

cgtcgcctca accctgatgg gcgaactgtg cgcaccgagg acaagatcct gcacatagtc      780

atcaagcgtg gctggaagga aggcaccaag atcaccttcc ccaaagaagg cgacgccaca      840

cctgacaaca tccctgctga catcgtcttt gtgctcaaag acaagcccca tgcacacttc      900

cgccgagatg gcaccaacgt gctctacagt gccctgatca gcctcaagga ggcgctgtgt      960

ggctgcactg tgaacattcc cactatcgac ggccgagtga tccctttgcc ctgcaatgat     1020

gtcatcaagc caggcaccgt gaagagactc cgtggggagg gccttccctt ccccaaagtg     1080

ccaactcagc gaggagacct cattgttgag ttcaaagttc gcttcccaga cagattaaca     1140

ccacagacaa gacagatcct taagcagcac ctaccctgtt cctaggctct gccccagcca     1200

gtccagagcc taccacagca atacccccaa cactcactcc actcaatgtg cacccagctt     1260

gatgtccact ggacactggc aactttttct aaaatgcaaa aaaaagccac tggttttcag     1320

gaaaatgttc ctgtccctga ccccttttag agctgggctg cctgggggga gtgggaggga     1380

ggtggggaga gctagcccag gccaggggtc aatgttcatg tcactagctt tcaatccagt     1440

ttccactgca gtggctggag agtgacctga gtgctacttg aagatatgta gagattcctt     1500

atccatgcct gtacatagca tgtcctcctc ccctcagctt tgctaatacc agtcccctcc     1560

cttccctttg gcttcctgct gttgggggtg gaaaagacta gaaaggacat tgctttctca     1620

gccccacccc caggtccaca gtgtccaagg taatggcaca catattcatg cacaagaagc     1680

actcacctag agctgtctgt gcctctctgg gagaaaggag agaggataag aagggaaagt     1740

tcacaacctg tgaacaggga cttgagcacg agacactttt catctggagc aggggggtga     1800

gctcctcagc agcctccgta acagctgccc tgcctacacc tgcagagctg gaggttctgt     1860

cctccctgct gctctcagga gtgttcaagg gtggagggca gggaatgggg cctgaggtat     1920

taaggctaag aggtggggga cagggcccat ctaccagcct tcatcaggaa gggaaagggc     1980

tttggggtca ggtggcagct attccccacc aagagattca gggtcacagg tttttcccca     2040

cacctctgaa ctcagggcct agccaccccc aaacttccaa atcccacttt tgtgatatgt     2100

gaagctactc atttcttacc cttggaggct gtgtggggaa tttccagccc ttttatgcct     2160

gtgtgatccc accccacccc catagttgta taaaggtcat agtgaagaag ctgggggaag     2220

actgcttcag ccagatcctg gggtggggtc tttaggtttt ctcactttga caacccccga     2280

atgtttttat agtagttttt ttgtattttt ttgtaatgac agtattatgt aaaaaataaa     2340

gtatttt                                                               2347


<210> 823
<211> 3073
<212> DNA
<213> Homo sapiens

<400> 823
tctgccgttg ggtgaggcgc ggagcgaagt gaagggtggc ccaggtgggg ccaggctgac       60

tgaaaaagat ggatactatg atgctgaatg tgcggaatct gtttgagcag cttgtgcgcc      120

gggtggagat tctcagtgaa ggaaatgaag tccaatttat ccagttggcg aaggactttg      180

aggatttccg taaaaagtgg cagaggactg accatgagct ggggaaatac aaggatcttt      240

tgatgaaagc agagactgag cgaagtgctc tggatgttaa gctgaagcat gcacgtaatc      300

aggtggatgt agagatcaaa cggagacaga gagctgaggc tgactgcgaa aagctggaac      360

gacagattca gctgattcga gagatgctca tgtgtgacac atctggcagc attcaactaa      420

gcgaggagca aaaatcagct ctggcttttc tcaacagagg ccaaccatcc agcagcaatg      480

ctgggaacaa aagactatca accattgatg aatctggttc cattttatca gatatcagct      540

ttgacaagac tgatgaatca ctggattggg actcttcttt ggtgaagact ttcaaactga      600

agaagagaga aaagaggcgc tctactagcc gacagtttgt tgatggtccc cctggacctg      660

taaagaaaac tcgttccatt ggctctgcag tagaccaggg gaatgaatcc atagttgcaa      720

aaactacagt gactgttccc aatgatggcg ggcccatcga agctgtgtcc actattgaga      780

ctgtgccata ttggaccagg agccgaagga aaacaggtac tttacaacct tggaacagtg      840

actccaccct gaacagcagg cagctggagc caagaactga gacagacagt gtgggcacgc      900

cacagagtaa tggagggatg cgcctgcatg actttgtttc taagacggtt attaaacctg      960

aatcctgtgt tccatgtgga aagcggataa aatttggcaa attatctctg aagtgtcgag     1020

actgtcgtgt ggtctctcat ccagaatgtc gggaccgctg tccccttccc tgcattccta     1080

ccctgatagg aacacctgtc aagattggag agggaatgct ggcagacttt gtgtcccaga     1140

cttctccaat gatcccctcc attgttgtgc attgtgtaaa tgagattgag caaagaggtc     1200

tgactgagac aggcctgtat aggatctctg gctgtgaccg cacagtaaaa gagctgaaag     1260

agaaattcct cagagtgaaa actgtacccc tcctcagcaa agtggatgat atccatgcta     1320

tctgtagcct tctaaaagac tttcttcgaa acctcaaaga acctcttctg acctttcgcc     1380

ttaacagagc ctttatggaa gcagcagaaa tcacagatga agacaacagc atagctgcca     1440

tgtaccaagc tgttggtgaa ctgccccagg ccaacaggga cacattagct ttcctcatga     1500

ttcacttgca gagagtggct cagagtccac atactaaaat ggatgttgcc aatctggcta     1560

aagtctttgg ccctacaata gtggcccatg ctgtgcccaa tccagaccca gtgacaatgt     1620

tacaggacat caagcgtcaa cccaaggtgg ttgagcgcct gctttccttg cctctggagt     1680

attggagtca gttcatgatg gtggagcaag agaacattga ccccctacat gtcattgaaa     1740

actcaaatgc cttttcaaca ccacagacac cagatattaa agtgagttta ctgggacctg     1800

tgaccactcc tgaacatcag cttctcaaga ctccttcatc tagttccctg tcacagagag     1860

tccgttccac cctcaccaag aacactccta gatttgggag caaaagcaag tctgccacta     1920

acctaggacg acaaggcaac ttttttgctt ctccaatgct caagtgaagt cacatctgcc     1980

tgttacttcc cagcattgac tgactataag aaaggacaca tctgtactct gctctgcagc     2040

ctcctgtact cattactact tttagcattc tccaggcttt tactcaagtt taattgtgca     2100

tgagggtttt attaaaacta tatatatctc cccttccttc tcctcaagtc acataatatc     2160

agcactttgt gctggtcatt gttgggagct tttagatgag acatctttcc aggggtagaa     2220

gggttagtat ggaattggtt gtgattcttt ttggggaagg gggttattgt tcctttggct     2280

taaagccaaa tgctgctcat agaatgatct ttctctagtt tcatttagaa ctgatttccg     2340

tgagacaatg acagaaaccc tacctatctg ataagattag cttgtctcag ggtgggaagt     2400

gggagggcag ggcaaagaaa ggattagacc agaggattta ggatgcctcc ttctaagaac     2460

cagaagttct cattccccat tatgaactga gctataatat ggagctttca taaaaatggg     2520

atgcattgag gacagaacta gtgatgggag tatgcgtagc tttgatttgg atgattaggt     2580

ctttaatagt gttgagtggc acaaccttgt aaatgtgaaa gtacaactcg tatttatctc     2640

tgatgtgctg ctggctgaac tttgggttca tttggggtca aagccagttt ttcttttaaa     2700

attgaattca ttctgatgct tggcccccat acccccaacc ttgtccagtg gagcccaact     2760

tctaaaggtc aatatatcat cctttggcat cccaactaac aataaagagt aggctataag     2820

ggaagattgt caatattttg tggtaagaaa agctacagtc attttttctt tgcactttgg     2880

atgctgaaat ttttcccatg gaacatagcc acatctagat agatgtgagc tttttcttct     2940

gttaaaatta ttcttaatgt ctgtaaaaac gattttcttc tgtagaatgt ttgacttcgt     3000

attgaccctt atctgtaaaa cacctatttg ggataatatt tggaaaaaaa gtaaatagct     3060

ttttcaaaat gaa                                                        3073


<210> 824
<211> 12394
<212> DNA
<213> Homo sapiens

<400> 824
gagaccgctg caagtcccgg ggccctgcct ctatcgtcct aggggttccg cgggcaggag       60

caacccagaa gcaccggtga ggccagcgcg tcctcgcagc catgagcagt gagcaggata      120

aatcggccag caaagaaaaa tccaagaaac cagtaagatt tctaccacag ctgtctatgg      180

agaaattagc cagcaaagaa aagttcaagg caccagcaag agctttacca cagctgtcta      240

tggtgagtac aaagccccac tggcagcagg cagctccatc attccatttg agtgtaaagc      300

aggatgatga gagtccagaa ccatttagtg ttaaaaatga acagtcccat gctgaataca      360

tggaacgttt tggaaaaaag ggcaaattac cccaccaagt tgatgatagt tatgttggac      420

catctacttc caaatcaaag ggcaaatctc cacataaaga acgagaaaac tttagaagta      480

ctcttgttaa tgtcattatg caacaagatg ctgacttaga ctcagctgtc cctgatggaa      540

gcacaattcc aaaaccgacc gcttctgcta tagagaaaga catcttgaga tattactatt      600

atattcacca tggaattgat acagaccatg tagccccaat ggaagattct tggctagaac      660

acgtactgga tttagttcca caacatctga aagtcttcac tgacagcata gttacattat      720

ctgatgaaat gagagaggat tatcttctta gtgtaaggaa atccatagtt gattttgttt      780

taaaagatcc tcgagagaaa ggagatgata agaagacaga tgaacttcca gcccatcgtg      840

ctgaaatgga aattctgcca aaaccttgga ggaaatcttt tttagctgca agcagttata      900

ttagggatca cttgaatgca atgaacccca caatgctggc tgtactagat ttgtggcaca      960

ctaattttaa aaaattacgt ttagttgata tcaaagaatt tcataattgc caggatgcat     1020

tagagctgtc aagttttcag aacattatca tgagacacat ggactctgcc aaagagactc     1080

tacttaaaat gtggtttcca gaagtgcaga atatttatta ccaaggtaat aaaaaaaagc     1140

aattgccaac tggtgacagc agtgccaaat tggaatcttt tttcaactgt gctgctgcac     1200

ttatgacttt acagctgcag gacctcactt tagtctccat gcaagatttc acggacttaa     1260

ttgcacaacc cccagattct gttagagctt ttgaacatcc aggtttcatc atgaggctga     1320

ttcttgataa tgacaccatt aagtttgaac ctgagttgag tgactatata gatatctttc     1380

taaatgttta tgacgtcatg attaaagctg tcagttttgt gccaagagtt gagacaaaat     1440

tgtattccaa gtgggaaagt aagtctaaac caacaacctt gaagcccata attctgaatg     1500

aaattgtaga tgctcacaaa gaaaagatca aggaagttat tatgaaagag agtgtggcac     1560

ctactgagca cctcagactc tatgacaagt atgacttttt aattaccaga aaagctgagc     1620

gagatgttga taacttcctc gcagaaaatc atagttatga aaaaataata gatgaaattt     1680

gcaaatacca gaaactaata gaggaaatac agtacacatc cataaagact attcgtttag     1740

gaatgtttga aatgcactgt gaggaattaa tcagagcttt ggtgaagcga gcagatatta     1800

tttgtgggaa acttctagct aaaatgttca gagatcatca ggaagtaaat acaagattat     1860

gcgatgaatt tgagaggata gctgaaaaag ctcttagcac tcctccaaat acagcagaac     1920

taatggaaat gaaggcttac attcagaaag tggaggtaac tgatatgatt gaactagaac     1980

agagattagt ggattccaaa aactgcctcg ccttcctcat cgagtatgtc aacttttctc     2040

cagcagacat gaggctaaat aatagtgttt tccagtggta tggaaggatg ggagaaattt     2100

ttgaagaaca caggaaaatc attaaagaga aaatagaaca atatcaagaa ggtctgaagt     2160

tacggtgtga acggtttgtg gaggaattgg agagttatgc taagcaatca gaagaatttt     2220

attcatttgg agatcttcag gatgttcagc ggtacctaaa aaaggctcaa atactgaatg     2280

gaaagttgga tttagctgca gataagattg agcagtttaa tgctgaagag gaagcatttg     2340

gttggctacc atctgtatat cctcaacgta aaaaaatcca agatggcttg aacccttatc     2400

ttcgtcttta tgaaactgct gtcgaattta gcagcaacta tagagcatgg acagaagggc     2460

catatcataa agtgaatcca gaccaagtag aagcagatat tggaaattac tggagaggat     2520

tatataaact ggagaaaacc tttcatgatt ctccatatgc attggcaatg acaaaaaaag     2580

taagatcaaa ggtggaagat ttcaagcagc acattcctct cattcaagtg atctgtaatc     2640

ctggtttgcg ccccaggcac tgggaggcca tgtctgccat tgttggttac cctttgcagc     2700

catcagatga ctccacagtc tcctcttttt tagacatgaa tctggaacca tatatagacc     2760

gatttgaagg tattagtgaa gcagctagca aagaatattc tcttgaaaag gcgatggaga     2820

agatgattac tgagtgggat gcagtggaat ttgtcatcca ttcttataga gaaactggga     2880

catttatttt ggcatcagtt gatgaaattc agatgttgtt ggatgaccat attattaaaa     2940

cacaaactat gcgaggatct cctttcatta agccttatga aaaacaaatg agagaatggg     3000

agggcaagct cctactgctt caggagattc tggatgaatg gctcaaagtc caagccacgt     3060

ggctgtatct ggagcccatt ttcagctctc cagacattat gtctcaaatg cctgaggaag     3120

gcagacgatt tacagctgtg gataagacat ggagagatat aatgagaagt gtcatgcagg     3180

ataaacatgt tctgacagtt gtaaccattg acagaatgct ggaaaggctg aaaaaatcta     3240

atgaactttt ggagctcatt cttaaaggac ttaatgaata tttggaaaag aaacgcctct     3300

ttttccccag attctttttt ttgtccaatg atgaacttct tgagatacta tctgagacta     3360

aagatcccac tagggtgcaa cctcacttga agaaatgttt tgaaggaatc gcaaaggtag     3420

aatttacgga aactttagac attactcaca tgaagagcag cgaaggagag gttgtagaac     3480

tcatagagat tatttcaaca gccaaagcca gaggtcaagt ggagaagtgg ttggttgaat     3540

tagagagagt tatgattaac tccatccaca aggtaactgg agatgcaact tttgcctata     3600

caaaatatga acgaattaac tgggtaaggg attggcctgg acagactgtt ctctgtgtat     3660

cccaaatctt ttggacaaaa gaagtacaaa cagctattcc aatggggata aaggctcttg     3720

agcaatactt gaaaacatgt aacagacaaa ttgatgatat tgtcactttg gtgcgtggca     3780

aattgtccat gcagaatcgc gtaactctgg gagcacttgt ggtactggat gtccatgcta     3840

gagatgtcct ctcatcactt gtaaaaaaaa atattagcga tgactctgac tttgaatggt     3900

taagtcagct taggtactac tggcaagaaa atcatttaga aacaaaaatg atcaatgctg     3960

gtttgcgata tggatatgaa tatctgggta attcccctag gctggttatt acaccactca     4020

cggatagatg ttacagaacc ttatttggag cccttcattt gcaccttgga ggagcacctg     4080

agggtccagc tggcactggg aagactgaaa ctaccaagga tttggcaaaa gctgtagcca     4140

aacaatgtgt tgttttcaac tgctctgatg ggttggatta tttggctttg ggaaaattct     4200

ttaagggact gttatcttgt ggagcctggg cttgctttga tgagtttaac agaattgatt     4260

tggaagtact ctctgtggtt gctcaacaaa tccttactat ccaaagaggt attaatgcag     4320

gtgctgatat actgatgttt gaaggaactg aactaaaact tgaccccaca tgtgctgtct     4380

ttataacaat gaaccctggg tatgctgggc gatcagaact gccagataac ctgaaggctc     4440

tctttcggac agtagcaatg atggtacctg actatgccat gattgctgaa atagtcctat     4500

actcctgtgg gtttgtcact gctcgaccac tgtctgtaaa aattgtggct acgtatcgct     4560

tgtgttcaga gcagctgtca tctcaacatc actacgacta tggaatgaga gccgtgaagt     4620

cagttcttac tgctgctggg aatctgaagc tgaaatatcc aaatgaaaat gaagaaattt     4680

tgctgcttag atctatcatt gatgtaaatc tgccaaaatt tttatcccat gatttaccac     4740

tctttgaggg aattacttcg gatttgtttc ctggggtaaa attaccaaaa ccagattaca     4800

atgatttgct ggcagctatc aaagacaatt gtgcctccat gaatttgcaa atgactgcat     4860

tcttttccga gaagattctt caagtatatg aaatgatgat tgtgcgtcat ggttttatga     4920

ttgttggaga accatttgga ggaaaaacta gtgcatatcg tgtcttagct ggagcactaa     4980

atgatatatg tgaaaagggg ctaatggaag aaaacaaagt tcaaataact gttttaaatc     5040

ctaagtctgt caccatgggc caactgtacg gacagtttga ttcagtgtcc catgaatggt     5100

ctgatggggt ccttgctgtc agttttagag catttgcctc ttcagtgact ccagatagga     5160

aatggttaat ttttgatggc ccagtagatg cagtgtggat tgagaatatg aacactgtgc     5220

tggatgacaa caagaagcta tgtctgatga gtggggagat tattcagatg tcaccacaaa     5280

tgaatctaat ttttgagcca atggatttag aagttgcttc ccctgccact gtttccagat     5340

gtggcatgat ttacatggag cctcacatgt taggctggag accactgatg ttgtcctggg     5400

tgaatctgtt acctgcgtca gtcagtgtta ttcaaaagga attcataatg ggcttatttg     5460

acagaatggt ccctgtttcg gttgaattta ttagaaagca tacaaaggaa ttatctccta     5520

cttccgatac aaacttggtc cggtccttaa tgaatctaat agactgtttt atggatgatt     5580

ttgctgatga agtcaaacta aaggagagaa atgatcgaga aacttactct ttgcttgagg     5640

gcatttttct gttttcattg atctggtccg ttggtgcttc ttgtacagat gatgatcgat     5700

tgaaatttaa taagattctt cgagaactaa tggaaagtcc aatttcagat cgaactcgaa     5760

atacgtttaa attacagagt ggtactgagc aaacatcctc aaaggcacta actgtcccat     5820

ttcctgaaaa aggaacaatt tatgattatc aatttgtcac tgagggaata ggaaaatggg     5880

aaccatggat aaagaaattg aaagaagctc ctccaattcc taaagatgta atgtttaatg     5940

aaatcattgt gccaactctg gacacaattc gatactctgc attaatggaa ttgctgacca     6000

cccatcaaaa gccttcaata tttgtaggac caacaggaac tgggaaaagt gtttacatta     6060

cgaattttct tttaaatcaa ctaaataagg aaatctacaa acctctgcta attaacttct     6120

cagcacaaac tacagcagct caaactcaga atattgtcat gtcaaaattg gacaagagaa     6180

gaaagggagt ttttggtcct cctttgggca agagaatggt tgtctttgta gatgatgtca     6240

atatgcctgc tcgggaggta tatggggctc aacctcccat tgagttactt agacagtggt     6300

tagaccactg gaactggtat gatctaaaag attgttccat gattaaacta gtggacattc     6360

agatcatgtg tgctatggga cctccaggtg gtggtcgaaa tccagtaact cctcgataca     6420

tgcgacattt caatattata acaatcaatg agtttagtga taaatccatg tatacaatct     6480

tctctagaat cttaacttgg catttagaaa tctgttataa atttccagat gaatttctag     6540

atttgaccac acaaatcgta aatggcacaa tgactctgta taaagaagca atgaagaatc     6600

tcttgcctac tccagctaaa tctcactact tgttcaacct ccgtgatttc tcccgtgtca     6660

ttcaaggtgt ttgtttgtca agaccagaaa caacagaaac cacagaagtg attaaacgtc     6720

tttgggttca tgaggtcctt cgagtgtatt atgaccgcct tctggacaat acagacagaa     6780

gctggctcat caactacatt caagaaattt tgagaaacta catgtatgaa gattttcatg     6840

agctttttca gcgtttggat tttgataatg atggcatggt ggaagcagat gacttacgca     6900

gcttaatgtt ttgtgatttc catgatccca agagggagga taccaactac agagaaatcg     6960

cagatgtgga taatcttcga atgatagtag aaattcacct agaagaatac aacaatataa     7020

gcaaaaaacc catgaacctt gtcttgtttc gatttgccat agagcacatc agcagaattt     7080

ccaggatcct gaagcagcct cgcagccatg ctctcctagt aggggttgga gggagtggaa     7140

ggcagtctgt caccagatta gctgcccaca tggctgatta ttcagttttc caagttgaaa     7200

tctctaaggg gtatgatact actgaatggc atgaagattt aaaagtgatc ttaaggaaat     7260

gtgcggaagg tgagatgcag ggtgtcttcc tgtttacaga tactcaaatt aaagaagagt     7320

cttttctgga agatgtcagt aatctgctaa atgctgggga gattccaaat ctctttgcat     7380

tagatgagaa gcaagagata tgtgataaga tgcgtcagtt agatcgccag cgggataaaa     7440

ccaagcaaac agatggcagc cccatagccc ttttcaacat gtttattgat cattgccgca     7500

gccaactgca tgtggtcctt gccatgagtc ccattggaga tgcatttcgg aatcgtctta     7560

gaaagttccc tgctcttgtt aactgctgta ccattgactg gtttcagtca tggcctgaag     7620

atgcactcca ggcagttgcc tcacgattct tggaagaaat tgaaatgtca gaggaaatac     7680

gagatggctg tatcgacatg tgtaaaagct tccacacttc tactatagat ttatccaaat     7740

ctttctttgt tgaacttcaa agatacaatt atgtgactcc tacctcttac ctcgaattaa     7800

tctccacctt caaactgttg ttagaaaaga aaagaagtga agtaatgaaa atgaaaaaga     7860

gatatgaagt gggtttggag aaactggatt ctgcttcatc tcaagtagcc acaatgcaga     7920

tggagttgga ggcactacat cctcaattaa aagttgctag caaagaggtt gatgaaatga     7980

tgataatgat tgagaaagag tctgtagaag ttgccaaaac tgaaaaaata gtgaaagctg     8040

atgaaacaat agcgaatgaa caagctatgg cttccaaagc catcaaagat gagtgcgatg     8100

ctgacctggc aggtgccttg ccaatattag agtcagcact ggccgccctt gatactctta     8160

ctgcacagga tattacagtg gtaaaatcca tgaagagtcc tcctgctggt gtcaagcttg     8220

ttatggaagc tatatgcatc ttgaaaggaa tcaaagctga caaaatccct gacccaacag     8280

gttcagggaa aaaaattgag gatttctggg gcccagctaa gagacttctt ggtgacatga     8340

ggtttctgca gtcacttcat gaatatgaca aggacaatat tcctccagct tatatgaata     8400

tcataagaaa aaattatatt ccaaatccag attttgtacc agaaaaaatc agaaatgctt     8460

ctacagcggc cgaaggtctg tgcaaatggg tcatagcaat ggattcatat gataaagtgg     8520

caaaaatagt agctcccaaa aagataaaac tggctgcagc tgaaggggag cttaaaattg     8580

ccatggatgg tcttagaaag aagcaggcag cccttaagga agttcaggac aagctggcca     8640

ggcttcaaga cacacttgaa ttaaataaac aaaagaaggc tgacctggaa aaccaggttg     8700

acctttgcag caaaaaacta gaacgagctg aacagttgat tggaggcctt ggaggtgaga     8760

aaactcgatg gagccacaca gctctggagc taggtcagct gtacatcaac ttgactgggg     8820

atatcctcat ttcctccgga gtggttgctt acctcggagc cttcacatcc acctatagac     8880

agaatcaaac taaagagtgg acaactttgt gcaaaggaag agatatcccc tgctcagatg     8940

attgctctct tatgggtacc ctgggagaag ctgtgacaat tcgaacttgg aatattgctg     9000

gattaccttc tgactcattt tccattgata atgggataat cataatgaat gcaagaaggt     9060

ggcctctgat gatagatcct caaagtcagg ctaataaatg gatcaagaac atggaaaaag     9120

ccaatagtct ttatgtgatt aaacttagtg aacctgacta tgtcaggact ctggaaaatt     9180

gcatccagtt tggtactcct gtgttgctag aaaatgttgg cgaagaacta gatcctattt     9240

tggaacctct tctactaaaa caaaccttta agcagggtgg gagtacatgt atccggcttg     9300

gggactccac aattgaatat gcacctgact tccgcttcta tattactacc aagttaagaa     9360

atcctcatta tcttcctgaa acatcagtaa aggtaacatt attaaacttc atgataaccc     9420

ctgagggaat gcaagatcag cttctgggaa ttgtggtggc acaagaaagg ccagaccttg     9480

aagaagaaaa gcaagccttg atattacaag gagctgaaaa taaaaggcag ttaaaagaaa     9540

tagaagacaa gattttagaa gttctttcat cttcggaagg caatatatta gaagatgaaa     9600

ctgctattaa gatattatct tcctccaagg ccttggctaa tgagatttct cagaagcagg     9660

aagtagccga agagacagag aaaaagattg acaccacccg catgggctat cgtcctattg     9720

ccatccattc ttccatccta tttttttctc ttgctgattt agccaacatt gagcccatgt     9780

accagtattc actgacctgg tttattaacc ttttcatcct gtctattgaa aattcagaga     9840

aatcagaaat tttggcaaaa aggcttcaga ttctcaagga tcactttact tattcactgt     9900

atgttaatgt ctgccggtca ctctttgaaa aggataagct gctcttttcc ttttgtctaa     9960

ccataaatct actgctgcat gagcgggcga ttaataaagc tgagtggaga tttctgctaa    10020

ctggtggcat tggactggat aatccttatg ccaacctttg tacatggctt cctcagaaat    10080

cctgggatga aatatgtcga ttagatgatt tgcctgcctt caaaaccatt cgtagagagt    10140

ttatgcgctt aaaggatgga tggaagaaag tatatgatag tttggaacca caccatgagg    10200

ttttccctga agaatgggaa gataaagcaa atgagtttca aaggatgctt attattcgtt    10260

gcttgaggcc agacaaggtt attccaatgt tgcaggaatt tataatcaac agattgggac    10320

gtgcattcat tgaaccaccc ccctttgatt tagccaaggc atttggagac agtaactgct    10380

gtgcaccact gattttcgtg ctctctcctg gagcagatcc catggctgcc cttctaaaat    10440

ttgctgatga ccagggatat gggggatcaa aacttagctc tttatctctt ggtcaaggcc    10500

aagggcccat tgctatgaag atgttagaaa aagctgtcaa ggaaggaaca tgggttgttc    10560

ttcagaattg tcaccttgcc acctcttgga tgccaaccct tgagaaagtc tgtgaggagt    10620

taagcccaga gtcaacacat ccagatttcc gaatgtggct aacgagttac ccatctccaa    10680

atttccctgt gtcagtactg cagaatggag tgaaaatgac caatgaagca ccaaaaggtt    10740

tacgggctaa tatcattcga tcatacctca tggacccgat ctctgatccg gagttctttg    10800

gcagctgcaa aaagcctgag gaattcaaga aattgcttta tggcctgtgt ttctttcatg    10860

ctttggtaca agaaagacgg aaatttggac ccctagggtg gaatattcct tatgagttca    10920

atgagacaga tctgagaatc agcgtacagc agctccacat gttcctgaac cagtatgagg    10980

aactgccgta tgaggctctg cggtacatga ctggcgaatg caattacgga ggcagagtga    11040

ccgatgactg ggaccggcgc acgctgcgca gcattctaaa caaattcttc aatcccgaat    11100

tagttgaaaa ttcagactat aagttcgact caagtggcat ctattttgtt cctccttctg    11160

gtgatcacaa aagctacatc gaatacacaa agactctgcc actgacccca gcaccagaaa    11220

tctttgggat gaatgccaat gcagatatca ctaaggatca gtcagaaact cagctgctat    11280

ttgataacat tcttcttaca cagtctcgtt cagcaggtgc tggtgcaaaa tcatcagatg    11340

aagtagtgaa tgaggtcgct agtgacatct tgggcaaact tccaaacaac ttcgacatcg    11400

aggctgccat gaggaggtac ccaacaactt atactcagag catgaacact gtacttgtcc    11460

aagagatggg acggttcaat aagttactga agaccataag agattcgtgc gtaaatattc    11520

aaaaagcaat caaggggctt gcagtcatgt ctacagatct tgaagaagtg gttagcagca    11580

ttttgaatgt caaaattcca gaaatgtgga tgggtaaatc ctacccaagc cttaaaccac    11640

ttggcagcta tgtgaatgac ttccttgcaa gactaaaatt cttgcagcaa tggtatgagg    11700

ttggtcctcc tccagtcttc tggctttctg gcttcttctt cacacaagcc ttcctgaccg    11760

gtgcccagca gaactacgcc aggaaataca caattcctat tgatcttctt gggtttgact    11820

atgaagtgat ggaagacaaa gaatacaagc atcctcctga ggatggtgtt ttcattcacg    11880

gattatttct ggatggagct tcctggaata gaaagatcaa gaaacttgca gaatcgcatc    11940

ccaaaattct ttatgataca gtgcctgtga tgtggctaaa gccctgtaag agggcagata    12000

taccaaaacg gccaagttat gttgctccat tgtataagac aagtgagcgg agaggagtat    12060

tatccaccac tggccattcc acgaattttg tgattgccat gactcttccc tctgaccaac    12120

ccaaggaaca ctggattgga cgaggtgtag cactgttatg tcaacttaat tcataaccag    12180

aagacatcat ttccttgttc ctatttcttg ttggctggct gagtagagaa agcatatttt    12240

actacttaaa cctttttttt tgtttgttta aatacatttg actaaagtta taattatgaa    12300

tttacttatg agcaaatgca gctaaactta atatgactca tacttaaatg taaggaaatg    12360

ttctgaaata aagactaaag aaaacacact ggca                                12394


<210> 825
<211> 1836
<212> DNA
<213> Homo sapiens

<400> 825
atgtcttcaa gacaggataa atcggccagc aaagaaaaat ccaagaaacc agtaagattt       60

ctaccacagc tgtctatgga gaaattagcc agcaaagaaa agttcaaggc accagcaaga      120

gctttaccac agctgtctat ggtgagtaca aagccccact ggcagcaggc agctccatca      180

ttccatttga gtgtaaagca ggatgatgag agtccagaac catttagtgt taaaaatgaa      240

cagtcccatg ctgaatacat ggaacgtttt ggaaaaaagg gcaaattacc ccaccaagtt      300

gatgatagtt atgttggacc atctacttcc aaatcaaagg gcaaatctcc acataaagaa      360

cgagaaaact ttagaagtac tcttgttaat gtcattatgc aacaagatgc tgacttagac      420

tcagctgtcc ctgatggaag cacaattcca aaaccgaccg cttctgctat agagaaagac      480

atcttgagat attactatta tattcaccat ggaattgata cagaccatgt agccccaatg      540

gaagattctt ggctagaaca cgtactggat ttagttccac aacatctgaa agtcttcact      600

gacagcatag ttacattatc tgatgaaatg agagaggatt atcttcttag tgtaaggaaa      660

tccatagttg attttgtttt aaaagatcct cgagagaaag gagatgataa gaagacagat      720

gaacttccag cccatcgtgc tgaaatggaa attctgccaa aaccttggag gaaatctttt      780

ttagctgcaa gcagttatat tagggatcac ttgaatgcaa tgaaccccac aatgctggct      840

gtactagatt tgtggcacac taattttaaa aaattacgtt tagttgatat caaagaattt      900

cataattgcc aggatgcatt agagctgtca agttttcaga acattatcat gagacacatg      960

gactctgcca aagagactct acttaaaatg tggtttccag aagtgcagaa tatttattac     1020

caaggtaata aaaaaaagca attgccaact ggtgacagca gtgccaaatt ggaatctttt     1080

ttcaactgtg ctgctgcact tatgacttta cagctgcagg acctcacttt agtctccatg     1140

caagatttca cggacttaat tgcacaaccc ccagattctg ttagagcttt tgaacatcca     1200

ggtttcatca tgaggctgat tcttgataat gacaccatta agtttgaacc tgagttgagt     1260

gactatatag atatctttct aaatgtttat gacgtcatga ttaaagctgt cagttttgtg     1320

ccaagagttg agacaaaatt gtattccaag tggagaaaca aagcaaaacc aggacatttt     1380

tacttttctc atattcaaag gtctgtcacc tttcagcatt ctgaagtttc gtctcctcag     1440

aactctcatt ttaagattgt gtcacccttc agtgttcttg gctttacatg gagatgccaa     1500

ttatgacttc caactttgct cgaccttgag gctttgtttc ctggcagccc ctcccatgca     1560

tccaccttgc cggaaactca ttaaagcaaa gcttagacca ccaaggatca gcagggtccc     1620

cagggcagct gctcacttct gcacataatg acctttcaac tcatgctttc tctcattttg     1680

gtcccttaga cttttttttt tgttgttatt tccttagcta tacgttataa aagataaagt     1740

cagctttatt atcctggcat atttatgtgt tttgaattga gtagttgttt tctggatatc     1800

tattcctcat actaccatga atagaagtct ctcaag                               1836


<210> 826
<211> 1019
<212> DNA
<213> Homo sapiens

<400> 826
agggatccct gggagccgcg gtgcattgtg ggagaacgaa agatggcggc gcccgtaagg       60

cggacgctgt taggggtggc ggggggttgg cggcggttcg agaggctctg ggccggcagt      120

ctaagctctc gcagcctggc tcttgcagcc gcaccctcaa gcaacggatc cccatggcgc      180

ttgttgggcg cgttgtgcct gcagcggcca cctgtagtct ccaagccgtt gaccccattg      240

caggaagaga tggcgtctct actgcagcag attgagatag agagaagcct gtattcagac      300

cacgagcttc gtgctctgga tgaaaaccag cgactggcaa agaagaaagc tgaccttcat      360

gatgaagaag atgaacagga tatattgctg gcgcaagatt tggaagatat gtgggagcag      420

aaatttctac agttcaaact tggagctcgc ataacagaag ctgatgaaaa gaatgaccga      480

acatccctga acaggaagct agacaggaac cttgtcctgt tagtcagaga gaagtttgga      540

gaccaggatg tttggatact gccccaggca gagtggcagc ctggggagac ccttcgagga      600

acagctgaac gaaccctggc cacactctca gaaaacaaca tggaagccaa gttcctagga      660

aatgcaccct gtgggcacta cacattcaag ttcccccagg caatgcggac agagagtaac      720

ctcggagcca aggtgttctt cttcaaagca ctgctattaa ctggagactt ttcccaggct      780

gggaataagg gccatcatgt gtgggtcact aaggatgagc tgggtgacta tttgaaacca      840

aaatacctgg cccaagttag gaggtttgtt tcagacctct gatgggccga gctgcctgtg      900

gacggtgctc agacaagtct gggattagag cctcaaggac attgtgtgat tgcctcacat      960

ttgcaggtaa tatcaagcag caaactaaat tctgagaaat aaacgagtct attactgtg      1019


<210> 827
<211> 1231
<212> DNA
<213> Homo sapiens

<400> 827
cgatccggta cttggaggtt cgaagctcct agtttcgggt tgagaccgat gtggagggcg       60

atgacgcgcg ggttccttga catcgaggat cagtaacacc cggagtgggt ggggaacgag      120

gggggcggcc cctgagctca ggccccgccc ctttccgggg acgtttcacc ggattggctg      180

tccttccata acgacatgcg gccccgcccc ggcgcgcgcc ccgccgcgtg cccagcccgg      240

gtagctgctg cagcctacgc tgcctcggcc actgcctgcc gcgtgcggag ccggagcccg      300

agcctgagtg gcgccgggcc cgacgtgggg ctcctgggcc gcggcggcgg gcgggcgatg      360

ctccagaggc ctgaccagcc atggaggccg aggcaggcgg cctggaggag ctgacggacg      420

aggagatggc ggcgctaggc aaggaagagc tagtgcggcg cctgcggcgg gaggaggcgg      480

cgcgcctggc ggcactggtg cagcgcggcc gcctcatgca ggaggtgaat cggcagctgc      540

agggccacct gggcgagatc cgcgagctca agcagctcaa ccggcgtctg caggcagaga      600

accgtgagct gcgcgacctc tgctgcttcc tggactcgga gcgccagcgc gggcggcgcg      660

ccgcacgcca gtggcagctc ttcgggaccc aagcatcccg ggccgtgcgc gaggacctgg      720

gcggctgttg gcagaagctg gccgagctgg agggccgcca ggaggagctg ctgcgggaga      780

acctagcgct taaggagctc tgcctggcgc tgggcgaaga atggggcccc cgcggcggcc      840

ccagcggcgc cgggggatca ggagccgggc cagcacccga gcttgccttg cccccgtgcg      900

ggccccgcga cctaggcgat ggaagctcca gcactggcag cgtgggcagt ccggatcagt      960

tgcccctggc ctgttccccc gatgattgaa ggcactgctt cctccacgcc gacgcccgcc     1020

cggattgctc cccgagcccc gggaccgctg tggacctcgg gacctggacg ccgtcctggc     1080

tgcgcaggag gggccgctgg catggactaa gaaatcctga caccaagaag ggcccctcgc     1140

tcttgctggc agggcagcag ggggactgaa ggctggagcg gagggacttg ctgggggttg     1200

gattgggggt aataaacccg gacggaagcg g                                    1231


<210> 828
<211> 1540
<212> DNA
<213> Homo sapiens

<400> 828
gtgcggcgcg cgtgggcagg tcattgcagt tgggcgctca gcagctgtgg cagccggttg       60

aggtctggaa gtagcgttgg gctgaagcag cggagttcgc catgcgcgag tgtatctcta      120

tccacgtggg gcaggcgggt gtccagatcg gcaatgcctg ctgggaactg tactgccttg      180

aacatggaat tcagcccgat ggtcaaatgc caagtgataa aaccattggt ggcggggacg      240

actccttcaa cacgttcttc agtgagactg gagctggcaa gcacgtgccc agagcagtgt      300

ttgtggacct ggagcccact gtggtcgatg aagtgcgcac agggacctac aggcagctct      360

tccacccaga gcagctgatc accgggaagg aagatgcagc cagtaattac gccaggggcc      420

attacaccat cggcaaggag attgttgacc tagtcctgga ccggatccgc aaactggcgg      480

atctgtgcac aggactgcag ggcttcctca tcttccacag ctttgggggc ggcactggct      540

ctgggttcgc atctctgctc atggagcggc tctcagtgga ttacagcaag aagtccaagc      600

tagagtttgc catttaccca gccccccagg tctccacagc cgtggtggag ccctacaact      660

ccatcctaac cacccacacg accctggaac attctgactg tgccttcatg gtcgacaatg      720

aagccatcta tgacatatgt cggcgcaacc tggacattga acgtcccacg tacaccaacc      780

tcaatcgcct gattgggcag atcgtgtcct ccatcacggc ctccctgcga tttgatgggg      840

ccctgaatgt ggacttgacg gaattccaga ccaacctcgt gccgtacccc cgcatccact      900

tccccctggc cacctacgcc ccagtcatct cagctgagaa ggcctaccac gagcagctgt      960

ctgtggccga gatcaccaat gcctgcttcg agccagccaa tcagatggtc aagtgtgacc     1020

ctcgccatgg caagtacatg gcctgctgca tgttgtacag gggggacgtg gtccccaaag     1080

acgtcaatgc ggccatcgcc accatcaaga ccaagcgcac tatccagttt gtggattggt     1140

gcccgactgg atttaaggtg ggcattaact accagccccc cacagtggtc cccgggggag     1200

acctggccaa ggtgcagcgg gccgtgtgca tgctgagcaa caccacggcc attgcggagg     1260

cctgggcccg cctggtccat aagttcgatc tcatgtatgc caagtgggcc tttgtgcact     1320

ggtacgtggg cgaaggcatg gaagagggag agttctctga ggcccgcgag gacctggcag     1380

ctctagagaa ggattgtgaa gaggtgggcg tggattccgt ggaagctgag gctgaagaag     1440

gcgaagcata ctgaggggag ggtgtggtgg gttctcccct gccaccccta ggatggctgc     1500

tttcaagttg tttgcaatta aagattctgt ataaaaccaa                           1540


<210> 829
<211> 3497
<212> DNA
<213> Homo sapiens

<400> 829
gttttcctgc tcccagcagg gttaggcttg ctgaggggca ggcacaggag tcctggctga       60

gctcatggcc tgaggctgcc tagcggccac ggggaatggt tgcaatggcg gaggcagagg      120

caggggtggc agtggaggtc cgtggactgc cccctgccgt gcccgacgag ctgctcactc      180

tctactttga aaaccgccga cgctctggag ggggacctgt gttgagctgg cagagactgg      240

gctgtggggg cgtcctcacc ttcagagagc ctgcagacgc cgagagggtc ttggcccagg      300

cagatcacga actacatggt gcccagctga gcctgcggcc agctccacca cgagcccctg      360

cacgcctgct gctccaagga ctgccccctg gcaccacgcc ccagcgcttg gagcagcatg      420

tccaggcctt gctgcgggcc tcggggctcc cagtacagcc ttgctgtgcc ttggccagcc      480

cccggccaga ccgggctctg gtccagttgc ccaagcccct ttctgaggca gatgtccgtg      540

tcctggagga gcaggcccag aatctgggcc tggaggggac cttggtgtcc ctggcccggg      600

ttccccaggc ccgagcggtg cgtgtggtgg gggatggtgc ctctgtggac ctgctgttgc      660

tggagttgta cctggagaat gagcgccgca gtggtggggg gcccctggag gacctgcaac      720

gcctacccgg gcccctgggc actgttgcct ccttccagca gtggcaagtg gcagaacgag      780

tgttgcagca ggagcaccgg ttgcagggct cagagctgag ccttgtcccc cactacgaca      840

tcctggagcc cgaggagctg gctgagaaca ccagtggagg ggaccacccg tccacccagg      900

ggcctagggc taccaagcat gctctcctga ggaccggagg gttggtgacg gctctgcagg      960

gtgcagggac tgtgacaatg ggctctggcg aggaaccagg gcagtcaggg gcctctctga     1020

ggacaggtcc catggtgcag ggtagaggga ttatgacaac aggctctggc caggaaccag     1080

ggcagtcagg gacctctctg aggacaggtc ccatggggtc tctgggacag gcagagcaag     1140

tcagctcgat gcccatgggg tctctggaac atgaggggct ggtaagcctg aggcctgtgg     1200

ggttgcagga acaggagggg cccatgagcc tggggcctgt ggggtctgca ggcccagtgg     1260

agacctctaa ggggttgctg gggcaggagg gcctggtgga aattgccatg gactcaccag     1320

agcaagaggg gctggtgggt cccatggaga tcaccatggg gtctctggag aaggcagggc     1380

ctgtgagccc aggatgtgtg aagctggcag ggcaggaggg cctggtggag atggtgctat     1440

tgatggagcc aggggcgatg cgcttcctgc agctctacca tgaggacctt cttgcgggcc     1500

tgggagacgt cgctctcttg ccacttgaag gaccggatat gactggcttt cggctctgtg     1560

gagcccaggc ttcctgccag gcggctgagg agtttctgcg gagcctgctg ggcagcatta     1620

gctgccatgt gttgtgcctg gagcacccgg gcagcgccag gtttctcctg ggcccagaag     1680

ggcagcacct tctccagggg ctggaggctc agttccagtg tgtctttggg acagagcgcc     1740

tggccacagc cacgttggac acaggccttg aagaggtgga ccctaccgag gccctcccag     1800

tgctccctgg caacgcccac accctgtgga ccccagacag tacaggtggt gaccaggagg     1860

acgtgagcct ggaggaggtc cgagaactgc tggccaccct ggagggccta gacctagacg     1920

gggaggactg gctgcctcgg gagctggagg aggaagggcc tcaggagcag ccagaggagg     1980

aggtgacccc agggcatgag gaggaggagc ctgtggcccc cagcactgtg gcacccaggt     2040

ggctggagga ggaggccgct ctgcagctgg ccctccaccg gtcactggag cctcaaggtc     2100

aggtggctga gcaggaggag gctgctgccc tgcggcaagc cctaaccctc tccctgctgg     2160

agcagccccc gttggaggca gaagagcccc cagatggggg gactgatggc aaggcccagc     2220

tggtggtgca ctcggccttt gagcaggatg tggaggagct ggaccgggcg ctcagggctg     2280

ccttggaggt ccacgtccag gaggagacgg tggggccctg gcgccgcaca ctgcctgcag     2340

agctgcgtgc tcgcctggag cggtgccatg gtgtgagtgt tgccctgcgt ggtgactgca     2400

ccatcctccg tggcttcggg gcccaccctg cccgtgctgc ccgccacttg gtggcacttc     2460

tggctggccc ctgggatcag agtttggcct ttcccttggc agcttcaggc cctaccttgg     2520

cggggcagac gctgaagggg ccctggaaca acctggagcg tctggcagag aacaccgggg     2580

agttccagga ggtggtgcgg gccttctacg acaccctgga cgctgcccgc agcagcatcc     2640

gcgtcgttcg tgtggagcgc gtgtcgcacc cgctgctgca gcagcagtat gagctgtacc     2700

gggagcgcct gctgcagcga tgcgagcggc gcccggtgga gcaggtgctg taccacggca     2760

cgacggcacc ggcagtgcct gacatctgcg cccacggctt caaccgcagc ttctgcggcc     2820

gcaacgccac ggtctacggg aagggcgtgt atttcgccag gcgcgcctcc ctgtcggtgc     2880

aggaccgcta ctcgcccccc aacgccgatg gccataaggc ggtgttcgtg gcacgggtgc     2940

tgactggcga ctacgggcag ggccgccgcg gtctgcgggc gccccctctg cggggtcctg     3000

gccacgtgct cctgcgctac gacagcgccg tggactgcat ctgccagccc agcatcttcg     3060

tcatcttcca cgacacccag gcgctgccca cccacctcat cacctgcgag cacgtgcccc     3120

gcgcttcccc cgacgacccc tctgggctcc cgggccgctc cccagacact taaccgaagg     3180

ggccaccctc tggcctcctg cttcccaggc tcccagctcc gcacaggctg atgctccccg     3240

cccccaactg tggccgcctg agctgtcccc ggggacgccc ctgcctccct ctgcgggctc     3300

cagaaggcgg tgtgggggat ggcggtcagc agcggccgag gggggccggg ctaggtccca     3360

gcctgggccg accccaccac caggggtcag cagagcccag gaggcgacac cgcccgcccg     3420

ccgctcccag acctcgcccg agtcggctct gttgtttgaa taaacgtgaa cgtgaaccca     3480

ggcggaaggg acccggg                                                    3497


<210> 830
<211> 974
<212> DNA
<213> Homo sapiens

<400> 830
agcgagtccg cgcgggcggt gccggggcgg cggaggacgg cttcaggccc aaaggggatt       60

gggcggcggc tctaggtggc gggtcttggt ttgcggaagg ggctggagtc gctgcttctc      120

ggtgaccggc gcgtggcccg gccaatcctg ccgccgccac ccacccgcaa ccgcgtccgt      180

tgacggtcgg gtccttggtc gccgggtcct tgcgggcacc acagagcggg gtggcgtccg      240

ctccctcgag tcctcggtgc cagggaattc accgctcacc accccctgcc ccgccttggg      300

tcctgctcgg ggaccaaacc actggaaggc agtggcggga aacgggcgcc tgtgccggag      360

agttgaggga acatgagcca tttgcagagc ttattgttag acaccctctt gggaaccaag      420

catgtggaca gtgcagccct catcaaaatc caggagcgga gcttgtgtgt agcatcacca      480

ggtttcaatg taacgcccag tgatgtccga acactggtga atggatttgc caagaaccct      540

ttgcaagccc gaagagaagg actgtatttc aagggaaaag attacagatg tgtccgggca      600

gatgaatatt ctctttatgc caaaaatgag aacactggtg tggttgtcgt gaagacccat      660

ctgtatcttc tggtagcaac ttacactgag ggcatgtatc ctagcatctg tgtggaagcc      720

acagagagcc tgggagacta cctaagaaaa aaaggaagtt aagtcatcag aggcccatga      780

aagacaattt tattatttta gaagaaaatt gaagagccta aagaaaaaat attttatggt      840

tgaaaaaaca ctagacagaa ggcactaaaa aagaagaatg aattaaggga gcaattttta      900

ttacttccag agatcctctt ctttcactgg aattacttga tcaactgttt tttaataagt      960

gttggtcatc ggca                                                        974


<210> 831
<211> 5549
<212> DNA
<213> Homo sapiens

<400> 831
actcctgcac ggcgagtgct ggagcacgac gtaccgctcg ctcggtcagg gcgccccctc       60

cgcccgcctc ctgcttcctc ctccgctgcc tgccgccgcc gcctccacca ttgtataatg      120

ctcggggcgc gcaggcagag aacggcggag tcttagcttc agcctcgcct gctgcccgct      180

ccccggcgcc accctcgggc ccctggagcg gggcactccg catggagcgg gagtagctga      240

ggagtgggcg gaaacccctc ctgatgcgtt agttcccagg tggagctgca tgtgatatat      300

gttgggtaaa ggaggaaaac ggaagtttga tgagcatgaa gatgggctgg aaggcaaaat      360

cgtgtctccc tgtgacggtc catccaaggt gtcttacacc ttacagcgcc agactatctt      420

caacatttcc cttatgaaac tctataacca caggcccctg acagagccca gcttgcaaaa      480

gaccgtttta attaacaaca tgttgaggcg gatccaggag gaactcaaac aggaaggcag      540

cctgaggccc atgttcaccc cctcctccca gcccaccacc gagcccagcg acagctaccg      600

agaggccccg ccggccttca gccacctggc gtccccgtcc tcccacccct gcgacctcgg      660

aagcactacg cccctggagg cctgcctcac cccggcctca ctgctcgagg acgacgatga      720

cacgttttgc acctcccagg ccatgcagcc cacggctccc accaaactgt cacctccagc      780

cctcttgcca gaaaaggaca gtttctcctc tgccttggac gagatcgagg agctctgtcc      840

cacatctacc tccacagagg cggccacggc tgcgactgac agtgtgaaag ggacctccag      900

cgaggctggc acccagaaac tcgacggtcc tcaagagagc cgcgcagatg actcaaaact      960

gatggactct ctgcctggga attttgaaat aacgacgtcc acgggtttcc tgacagactt     1020

gaccctggat gacatcctgt ttgctgacat tgatacgtcc atgtatgatt ttgacccctg     1080

cacttcctca tcagggacag cctcaaaaat ggcccctgtg tctgccgacg acctcctcaa     1140

aactctggct ccttacagca gtcagcctgt caccccaagt cagcctttca aaatggacct     1200

cacagagctg gaccacatca tggaggtgct tgttgggtcc taagacccag ggacccagcg     1260

actatgccca cccagacccc agagcgttcc cataaccctg acagttctcc acactgtgca     1320

tgcacccttg cttgcctttt tcagagaaaa agaaaatttt acaacaggat cacactagtt     1380

tttgctttga gcagagttgg agtgccttca tccaagtatg accactttta atacactttt     1440

ttgagtggtt cctcagagac ctactaccct ggtataggaa agaatccatt tgaagacaat     1500

gttgcaatgt tgaatgacaa aaataaacag ttcaagtgaa gcacaaggat taagttggaa     1560

aagctgtaaa ttgcatgtgc atatttgtct attttttcta taagttttat tgcaagaggt     1620

aaagaagaaa actatatata tatatcttat ttagataatc tcagtacctt ttctggcatt     1680

tttgccctgt ataggttgac ttggcaattc ggccttttta gaggcattaa ctactcctcg     1740

taagtgttgc atttacatgg ctgtttagaa aactgctgcc caaatttatt ttatattttt     1800

gtacagattc tgcagtttat gatattgttt ttctaaaaac aaatgctgtt tatacatatg     1860

agatagctat tttgatagga tttgctcaca tagttcctgc aaacttcaga tgtacaagtt     1920

gcacttgtac ttttatagag ttgtaatgtt ttatatgtgt atggtgcaag agaaaattgg     1980

atcaaatcaa tctgcagttg atgtccccaa atgcaaacac aggcacacac atgcacacac     2040

ccataaacac acacacagtg ctttaagaaa gggccaggtg atatcacacc caaatttcac     2100

aagcactgac cccctggcac caacacccgc cagtactgtg acttccaaag ccagagccac     2160

atgtgctcat caaacttgca ttaagcagtt ggcgggagat ggctgtggag ctgggggttt     2220

aagtgatggt tctcttttgc tccctctttt gagggtaaag ctactgtctt tcttaagagt     2280

gtatttatgc caagtttgcg cttttaattg tttttatttt gttttttaat gaaaacccag     2340

atctttcctt tttggcataa tttttatgat gacctgaaat tttacatccg aacaaaattt     2400

tacatccgaa aagcaaccaa cttcttcatg gaactcagcc ctgttgcaat gcttagggcc     2460

cttaaagaag aaaatctccc cagaaggcat ccatcatgtt gcttaattgt cttctgcagc     2520

ttcctttccc tagagctttc cctgtgttgc taagagctga aaatggcatc ttcgtgatca     2580

ccacagtgag cttggctcgc ctcggccggc ccgggatgca ctcttacaac atgtgtgact     2640

cttgaacctg gagttcatca cattacgtca cagcttccca tctggttgct ttcctgagtc     2700

agctacttca cacttgtcaa ggctgtttta ccccaaaact cagacaggac tttctatgca     2760

tgttttccct cctcccccca attccccccc ccatcacctt atctcccagg acacacttga     2820

gaagtagctt tttattccta gtggtgtaca tttaatttta aaaaggttgc aatgtatcat     2880

gcttgttgcc gaaactgttt atggccttct tgtttcagtt ttttcttttc ttccaatggt     2940

actttagctg ttgagtgcag gttacaacct atattgttat gcagatggct tctttaggaa     3000

taacttttat atttatttaa aaatttttaa attatgggat gttttgttgt tgttgttgtc     3060

tttgttgttg gtcatttgtc aatattcagt caccaattct gctcacttct tgccatggat     3120

aaaattgggt ctttctggct aattaaaaaa gacaacttta taaaatggca ctttaagcaa     3180

gccatagtta gttttatttt tgtaatgcac atggcaaagc aaagacgttt gtgatgaagg     3240

aactgctcat ctaagcaaaa gatttgagta tgatatgata aaggctttct acattctaat     3300

ttactttttc cccccacttg aatgtgtttt aaaggctaat tatcagctca gtagagcagt     3360

gagaaactga tcaaattgca cttgttctcc tacaagcaac ctccacgcag acacctcgta     3420

ctgctacagg tgtgtcattt cctttaatag gaccagggac catgtaactg aggtgagggt     3480

tgtagtagat gcttccagtg tcagtatgcc tgttaatttt aagagcttcc ctttcttgca     3540

gagaacaagt ctgcccagat tccatgcttt ctataactgg aggacctggc aaacctgccg     3600

catgctgcac acatctacct acgtacacat atacaatagt attgatgatt ctgaacaata     3660

acagggtaaa acagttggtt tgccattgtt aaaaactgat ttacagtaac ttacaacaac     3720

tgtacttttg ttggattagc aaatcatgtg tttaaacaaa tcccatatgt tgggcaacag     3780

ttcaaataag cacggagaag tgttgcccaa acttggttct ctgactctta tgtatttgta     3840

aggctgggct tcaaaatcaa aacaaaaacc ccaaaaacag caggcaaatg ctttttaact     3900

ctgacaccgt tgccataaat ccctgatact caaagtctaa caagaaagac atggaaaatt     3960

agcagcccat tttcagaaag atcaaaatga tctagggttc taattgcttt tgcatcctat     4020

tcttacaaag tgatgtccca acagggaaca gtaggagctg gagtgggatc tccaagtccc     4080

agtttgagtg tgggatgtgc ttccagcagt gccttccctt tatgaaagac atcacatggc     4140

atccagggcc aggcaggcag cttgaggtgc ctttacgaga aaaccgagct ggggctggga     4200

gaggacagtt attgacactg atgtgcaatg aagtgacaag atgagagcag aatcgtaaga     4260

gctttgaatt tgaagtgagt ttttttcccc ccataagtta tttattcctt ttttctgtgt     4320

aaatatattt attttactgt ggagcgctaa catctggatc gtaacatgtg cagaatgtat     4380

ggtaggaatg tattctcttg taggaatgta aatctgtatt aaaagggggt ccaagccagg     4440

cccccaggtc ttctcattgt atgcacagtc cgcattcatt tttactcttc tctaatatgg     4500

gtctatttga aatatgcaaa aggtatgagg aatgttttaa tacctccaaa tttttaagaa     4560

aagcatcaaa gggttgatat tttttaaagt ttttttagta gcactttctc tggatgacag     4620

aaggagcaac cacatgggca cccttgttca taccaaaggg tgagcagtgg ccagagcctc     4680

ctctgcacct ctcgagtgtc tttaccaatt gagcttttta tcgccatagc cccttggagt     4740

gccccagctg ccctgaggtc aatcaaggaa aatttcttaa tgaaataagc tccaaagagc     4800

caaagtatca acttacagat cgtttttaaa gcttaaattt atgaaccacc tttgtggtaa     4860

acaatgaatt atgaataccg cagggcagcc ttcttaaatg acaaatgtaa aaaaaaaaaa     4920

aaaaaagact ctacttcgtg cagcaattgc tactctatac gaattgtctt aatttgaaaa     4980

ccttgctgtt acaaattgga cctttataca ttttctgaaa acaatgaaaa gagtatattt     5040

aaccttttct ggctgtaaat ggttaccttc ctgtaactgc cccgcacctg gaggcatgga     5100

gttgtgtgca tcctgcttat gtacaattgt tttcagtgtt tctaagaatg agtctgaatg     5160

gttcttgaaa attagccagg atcaaatgct attgcagaca aagccaataa aaagttggac     5220

ttcttttggg gataacaagt tttggaagag aaatgcaggc catatgtgcg catgaccgag     5280

attttgaaaa aagatgtaca tagtgacatg tttggtgcat ggtttttgag gagggctttt     5340

gtcaaaaagg aggtataacc tttcccccac agacctgaga gctgtgcctt ttctatgcaa     5400

tattacagac gttacatcgg aacccagatg gctgtattca catgtaggtt tgggctgtaa     5460

tctaaacaat tggacagatt aaatgtacat ggaaatgagc agtcttactt ttgtagtttt     5520

atattataca ataaacagtt aaaagatga                                       5549


<210> 832
<211> 3257
<212> DNA
<213> Homo sapiens

<400> 832
agagacccga gtgcacgtgt ggagaagcgg cggcacaagc gcggcggcgg gagacactcc       60

cgcccccacc agactcaagc cctcactcga ctctcgcggc cttcgttgct cgcacagctc      120

cctgcccagg ctaggaggcc ggcttgcggg gttgagtggc ccgagctaag ggtgcggaga      180

cctaagggcg gcgactacga cggcgttgat atcggtggta acgacggcct cagcaggcgg      240

ggaagatgaa aggtagccgg atcgagctgg gagatgtgac accacacaat attaaacagt      300

tgaaaagatt gaatcaggtc atctttccag tcagctacaa tgacaagttc tacaagaagt      360

ttggctttga gattattgag acaaagaaga actactataa gaggatagag cccgcagatg      420

ctcatgtgct gcagaaaaac ctcaaagttc cttctggtca gaatgcagat gtgcaaaaga      480

cagacaactg aacaaattac aaatgaactt tcttgcactt gcttgtcgcc aaataaaaga      540

gaggcccatt gattcctccc ccaccccaac acttttcttt taaagctttt ctccctcctt      600

gttcttgttt ttctttcttc ctttcctttt ctctgagagt tttaatactt tcaaggactt      660

taaaaaaata atcatgtttg aattgttttc tcttattttt gtgaggtggt ttgaaggaag      720

gacaaggtag atctgtttag ttttgcagtt gaagttagat ggtcctaaac atttaattgt      780

caaataattt caaatttaat gtcctgcttt cacattgaag ggcagagcct acaaaacatt      840

gtatatttca aaagacaaaa agaagcagca gcagtatctt gttctctaat tcatagacaa      900

gttgagtgtg tttgtggtac tttgggtttt taaacacttt gggatactaa tccctagaca      960

ttgccttcac tccaccttta gtccttctga gcactctctc gggagttgga acattgttat     1020

ccttgtaaga aatactaagc ttatgttgat ttttaagtaa ttatatcttc tcttcttgct     1080

ggtgggtggg gcagtttggt ttagtgttat actttggtct aagtatttga gttaaactgc     1140

ttttttgcta atgagtgggc tggttgttag caggtttgtt tttcctgctg ttgattgtta     1200

ctagtggcat taacttttag aatttgggct ggtgagatta atttttttta atatcccagc     1260

tagagatatg gcctttaact gacctaaaga ggtgtgttgt gatttaattt tttcccgttc     1320

ctttttcttc agtaaaccca acaatagtct aaccttaaaa attgagttga tgtccttata     1380

ggtcactacc cctaaataaa cctgaagcag gtgttttctc ttggacatac taaaaaatac     1440

ctaaaaggaa gcttagatgg gctgtgacac aaaaaattca attactgtca tctaatgcca     1500

gctgttaaaa gtgtggccac tgagcatttg attttatagg aaaaaatagt atttttgaga     1560

ataacatagc tgtgctattg cacatctgtt ggaggacatc ccagatttgc ttatactcag     1620

tgcctgtgat attgagttta aggatttgag gcaggggtaa ttattaaaca tattgcttct     1680

attcttggaa aaatagaagt gtaaaatgtt aataatacaa atgtcactgt gacctcctcc     1740

actgagagga ctggtttatg ccagatcatt ttccggcaca cacggagtgg ctttgacaga     1800

ttgataactt tgtaagatgg gagacatctg aaatattcat gttttccttt tgtagtccca     1860

tctccactat ttagaaatgt tctcagactt taaaataatg cacagggctt gagctttctg     1920

tcatttgact ttaaaaggaa gtttcattca tatttatcct cttatgtaaa attgcggtat     1980

aaagtctcat ttccaaatat gttaaatgac aaaattattt tataaaatgt ttatgcacac     2040

tttataacct taagttttta tttgagaatg tgaaagtaca aagtgcagta gacttcaaca     2100

atcttgagtg ccaagaataa tacagaaaaa gaagacagtt gatgaatgag tttatagggt     2160

tctaatctta agatggtaaa aatgtagaaa gaccttgctg gttttttggg ggtattcgtt     2220

tcttaaacaa tccaaatcta agcttagaag aaaagtttag cgttaagcac ctttatcttc     2280

atgaataagc ttcagcttgc tcttggcaag agaagagtgc ttgagttaca gaaggcataa     2340

gtagtttgaa gaatgcagca gcctttttgt aaacttccca gatatcaaaa tagactttga     2400

tatataaatg gttttctgag atgacactgc ctctatttct ataaccattt cacctggact     2460

atctaatcag tcctatgaat gtatccctaa atgtggttat tgaaaaccta atagctgcct     2520

catgacaagt acatgttatt taaggaggaa aaaatattaa attttgaatt gagtgtgtag     2580

gctccctatc attatatata gagtttcttt ttccacggta gtcagtgact taacctgaat     2640

tgtaaatgtt tgtaaagggt taattgtcct acatcaaact tagttaaata attccatcca     2700

cttatggagg aggaggagaa tgtggaagag gtaaaaagct gggcacaagt tcatatgcct     2760

atgagtcagt aaagactgaa gtaatgtcct atgttgagct ggttattttg atatatgata     2820

ataattatct ttgaagtaga acaattctgt taactggaaa atcacaggat atatccatca     2880

tatttttcag gacagatagt ttttactgtg gggcaaatag gttaaaatta cactatgtta     2940

gttgcattta ggttttaaag caaagaatct gtagagaaat ctatgcaata tatagtttgt     3000

ccagattagc tttcatttgg ggaatgaagt tctgaaatat ctaaagcagt ttactcatca     3060

attgaaaagt cctccaaaaa gagaactatt gggaaaccat ggtgtggtgg tggaaaagaa     3120

aagctccctc agttttttgg agggaataac ttaaaaaaat acttaaatgg ctaagtttac     3180

ttggtgcagt taagaattaa acttgtcaat tttaacattg ctgttacatc tgaaataaac     3240

ttatgtgatg ttctggt                                                    3257


<210> 833
<211> 3001
<212> DNA
<213> Homo sapiens

<400> 833
gaccgggagg cgctgccgct ctgggcagac ggttccggga gccgcacggt cccctctcct       60

tccccatcct ctcccctccc ctctccgggt tcccccaccc acaggagcct tgggccgacc      120

actcccccga tggcctcagc cacggaggac cccgttctgg agcgttattt caaaggccac      180

aaagctgcga tcacctcctt ggacctcagc cccaacggca agcaacttgc tactgcttct      240

tgggatacct ttctcatgct atggaatttc aagccacatg ctagagctta cagatatgtg      300

ggtcacaagg atgttgtaac cagcgtgcag ttttctccac atggaaactt attggcgtct      360

gcctcacgag acagaaccgt gagactctgg attcctgata agagaggaaa attctcagaa      420

tttaaagctc atacagctcc agttcgaagt gtagactttt cagctgatgg ccagtttcta      480

gctacagctt ctgaagacaa atccataaaa gtatggagca tgtatcgcca gcgcttcctg      540

tattccttgt atcgacatac acactgggta cgctgtgcca aattttcacc cgatggaaga      600

ctaattgtgt catgtagtga ggataaaact attaaaattt gggataccac aaataagcaa      660

tgtgttaata acttctcaga ttccgttgga tttgcaaatt ttgtggactt taaccctagt      720

ggtacatgca tagcttcagc aggttctgat caaactgtga aagtctggga tgtaagagtg      780

aacaaattac tacagcatta ccaagttcac agcggtggag ttaattgcat atcattccat      840

ccttcgggta actatctcat cacagcttct tcagatggta cccttaagat tctggacctc      900

ttagaaggaa ggctcatcta tacacttcaa ggacatacgg gacctgtctt tactgtttca      960

ttttcaaaag gtggagagct atttgcatca ggaggtgcag acacacaggt cttattatgg     1020

aggactaact ttgatgaatt gcattgtaaa ggtcttacca aaagaaatct caaaagatta     1080

cattttgatt caccaccaca tcttcttgat atctacccaa gaacaccaca tccccatgag     1140

gaaaaagttg agactgtaga aattaatcca aagcttgagg taatcgattt gcagatctct     1200

actccccctg ttatggatat cctttctttt gattctacca caacaacaga aaccagtggt     1260

aggactctgc cagacaaggg tgaagaggcc tgtggatatt tcttgaaccc ttccttaatg     1320

tcaccagaat gtttgccaac aaccacgaaa aagaaaacag aagacatgag tgacctcccc     1380

tgtgaaagtc aaaggagcat acctctcgct gtgactgatg ctttagagca tattatggaa     1440

caactcaatg ttttgacaca gactgtttca atcttggagc agcgactgac tttgacagag     1500

gataagctga aagactgcct tgaaaatcag caaaagcttt tcagtgctgt ccaacagaaa     1560

agctgaataa aaaattcatt ttcatttgtt gggcagaggc ccaataaatg aacaaatgta     1620

catacactca ggaaggtagt acaagatact ccatacaaca caaccatgtg ctatttatca     1680

tggcatttct taaaagggtg agcaacagaa caaaaggcag aaaaggcata cctaaggact     1740

aatttaaaca catatcaatg tgaaggacta atttaaatta ctatcattta tgattgcagt     1800

aataaagtga taagcattca agcaactctg tattttcccc atattatttt aaatgtccat     1860

tttcatttat aggccaaatc ctgccaggaa agtaaccaga tctctggatt tcactgttaa     1920

gtcatttcag attgaccata ttcagacagt catggggtga aataattcac ttacctccaa     1980

aatagcatcc tatatgccaa taatgagtta ttgatctgac tagttgtatg tctttctgtt     2040

caaaatagaa attatccttt cttactaatg ccttgaaaga atgaacaaat aaaaattccc     2100

agaccacaga atttccacag caagaataca cttattttaa ttaacaatag cacagatata     2160

gcatagggca gtgggttttt tagttaattt atggcgtact ttgtttatcc attggccaac     2220

ctgaaggaaa tgaaactcac ctatctttct atcacagatg aatgtgctag atgaatgatt     2280

tgggttgtat ctgatcatgg ttcacaaaaa ttatgttagt gtgttttcag tatgctaaaa     2340

agtcagagtg atacaaaagt gatatttaaa aatatacaca catgtatgta cacatgcttc     2400

agaaatattg ttgcttaggg tgatttgggc agctaaatag taagtacttt ttaaaatttt     2460

tgcatcatca tcttcctatt taatgaattg tgatttaaaa caaaatgaaa ataagccagg     2520

tattctaaaa gatcctggat acaaattaag aattttgctt tattttaaac caaattgaga     2580

ttaaattgaa gaaaagcaag caaattaatt tcagcttgat tatcaacctg tatcaagaac     2640

aaaaatggga ggaggtgtcc acatttatgg tgtgtatagg taacatgggg aaaatgctat     2700

tctgtgtttt ggaaaagaag aaatagtgcc gtcctattta tttctatatt tagaaatttt     2760

tctcaaagaa atttcaattg tatctatgag atgggtttct aagtatctta ttgtgtgtta     2820

taagtgcctt ttaatatcat actaagtgtg agcttctgga cattttcaag agcttacaaa     2880

aactaagtgg cattgtattt ttataacccc attgagaaga ctaagtaaga aatgaaatgt     2940

cctatcaatt ttattttgtc atgcttcaaa caataaagac atttctgctt taaaagaaaa     3000

a                                                                     3001


<210> 834
<211> 1544
<212> DNA
<213> Homo sapiens

<400> 834
cttgcgagaa gacacgtgcg cggaaggagc ttgcagtagc gggcggcaga gctggagtga       60

agggagctag tgtttaggta gcagtcacca ttatgctcaa agcggtgatc ctgattggag      120

gccctcaaaa gggaactcgc ttcagacctt tgtcttttga ggtgcccaaa ccattgtttc      180

ctgtggcagg ggtccctatg atccaacacc atattgaagc ctgtgcccag gtccctggaa      240

tgcaggagat tctgctcatt ggcttctacc aacctgatga gcccctcacc cagttcctag      300

aagccgccca gcaggagttt aaccttccag tcaggtacct gcaggaattt gcccccctag      360

gcacaggggg tggtctttac cattttcgag accagatcct ggctgggagc cccgaggcat      420

tcttcgtgct caatgctgat gtctgctccg acttcccctt gagtgctatg ttggaagccc      480

accgacgcca gcgtcaccct ttcttactcc ttggcactac ggctaacagg acgcaatccc      540

tcaactacgg ctgcatcgtt gagaatccac agacacacga ggtattgcac tatgtggaga      600

aacccagcac atttatcagt gacatcatca actgcggcat ctacctcttt tctcctgaag      660

ccttgaagcc tcttcgggat gtcttccagc gtaatcagca ggatgggcaa ttggaggact      720

caccaggctt gtggccaggg gcaggtacca tccgcctaga gcaggatgtg ttttcagccc      780

tggcagggca gggccagata tacgtgcatc tcactgatgg tatctggagt cagatcaagt      840

ccgcaggttc agccctctac gcctcccgcc tctacctgag ccgataccag gacactcacc      900

cagaacggct ggccaagcac accccagggg gcccatggat ccgagggaat gtgtacatcc      960

acccgaccgc caaggtggcc ccctcggctg tgctgggccc caacgtctcc atcgggaagg     1020

gggtgaccgt gggtgagggt gtgcggctcc gggagagcat cgtcctccat ggagccactt     1080

tgcaggagca cacgtgtgtt ctgcatagca tcgtgggctg ggggagcacc gtgggacgct     1140

gggcccgcgt ggagggtacc cccagtgacc ctaaccccaa cgatccccga gcccgcatgg     1200

acagtgagag cctcttcaag gacgggaagc tgctgcctgc tatcaccatc ctgggctgcc     1260

gagtccggat ccctgccgag gtgctcatcc tgaactcgat tgttctgcca cacaaggagc     1320

tgagccgaag cttcaccaac cagatcatcc tctgagtagg gctgccagaa ggcccccagc     1380

tcctacccac tccccttgag gctgctgcct gcttggccag cctctgtcca gaaaggacca     1440

gagaaagcca ggctggatcg tcacatgccg gggagcaatg tggatggcct ggggactcct     1500

gggttttctc cctcccgact ccctaataaa ccccgtgaac cttg                      1544


<210> 835
<211> 3170
<212> DNA
<213> Homo sapiens

<400> 835
gctaaccttg ccgcgggccg agccctgcct cgccatggac caggactatg agcggcgcct       60

gcttcgccag atcgtcatcc agaatgagaa cacgatgcca cgcgtcacag agatgcggcg      120

gaccctgacg cctgccagct ccccagtgtc ctcgcccagc aagcacggag accgcttcat      180

cccctccaga gccggagcca actggagcgt gaacttccac aggattaacg agaatgagaa      240

gtctcccagt cagaaccgga aagccaagga cgccacctca gacaacggca aagacggcct      300

ggcctactct gccctgctca agaatgagct gctgggtgcc ggcatcgaga aggtgcagga      360

cccgcagact gaggaccgca ggctgcagcc ctccacgcct gagaagaagg gtctgttcac      420

ggtgacgcgg ctctgtgacc tctcagtgga aggggactca gtgacctccg tgggctggtc      480

tgagcggggg aacctggtgg cggtgggcac acacaagggc ttcgtgcaga tctgggacgc      540

agccgcaggg aagaagctgt ccatgttgga gggccacacg gcacgcgtcg gggcgctggc      600

ctggaatgct gagcagctgt cgtccgggag ccgcgaccgc atgatcctgc agagggacat      660

ccgcaccccg ccactgcagt cggagcggcg gctgcagggc caccggcagg aggtgtgcgg      720

gctcaagtgg tccacagacc accagctcct cgcctcgggg ggcaacgaca acaagctgct      780

ggtctggaat cactcgagcc tgagccccgt gcagcagtac acggagcacc tggcggccgt      840

gaaggccatc gcctggtccc cacatcagca cgggctgctg gcctcggggg gcggcacagc      900

tgaccgctgt atccgcttct ggaacacgct gacaggacaa ccactgcagt gtatcgacac      960

gggctcccaa gtgtgcaatc tggcctggtc caagcacgcc aacgagctgg tgagcacgca     1020

cggctactca cagaaccaga tccttgtctg gaagtacccc tccctgaccc aggtggccaa     1080

gctgaccggg cactcctacc gcgtgctgta cctggcaatg tcccctgatg gggaggccat     1140

cgtcactggt gctggagacg agaccctgag gttctggaac gtctttagca aaacccgttc     1200

gacaaaggag tctgtgtctg tgctcaacct cttcaccagg atccggtaaa cctgccgggc     1260

aggaccgtgc cacaccagct gtccagagtc ggaggacccc agctcctcag cttgcatgga     1320

ctctgccttc ccagcgcttg tcccccgagg aaggcggctg ggcgggcggg gagctgggcc     1380

tggaggatcc tggagtctca ttaaatgcct gattgtgaac catgtccacc agtatctggg     1440

gtgggcacgt ggtcggggac cctcagcagc aggggctctg tctcccttcc caaagggcga     1500

gaaccacatt ggacggtccc ggctcagacc gtctgtactc agagcgacgg atgccccctg     1560

ggaccctcac tgcctccgtc tgttcatcac ctgcccaccg gagccgcatg ctcttcctgg     1620

aactgcccac gtctgcacag aacagaccac cagacgccag ggctgattgg tgggggcctg     1680

agaccccggt tgcccattca tggctgcacc ccaccatgtc aaacccaaga ccagccccaa     1740

ggccagacca aggcatgtag gcctgggcag gtggctcggg gccactggcg gagccagcct     1800

gtggatccaa gagacagtcc ccacctgggc ttcacggcat ccttgcagcc acctctgctg     1860

tcactgctcg aagcagcagt ctctctggaa gcatctgtgt catggccatc gcccggcggt     1920

cagtgggctt cagatgggcc tgtgcatcct ggccaagcgt caccctcaca ctggaggagg     1980

atgtctgctc tggacttatc accccaggag aactgaaccc ggacctgctc actgccctgg     2040

ctggagagga gcacaacaga tgccacgtct tcgtgcattc gccaacacgt gccctcacag     2100

ggccagcgtc ctccttccct gcgcaagact tgcgtccccc atgcctgctg ggtggctggg     2160

tcctgtggag gccagcagcg gtgtggcccc cgcccccagg ctgcctgtgt cttcacctgt     2220

cctgtccacc agcgccaaca gccgtgggga agccaaggag acccaagggg tccaggaggt     2280

gggcgccctc catccttcga gaagcttccc aggctcctct gcttctctgt ctcatgctcc     2340

caggctgcac agcaggcagg gagggaggca aggcagggga gtggggcctg agctgagcac     2400

tgccccctca cccccccacc accccttccc atttcatcgg tggggacgtg gagagggtgg     2460

ggcgggctgg ggttggaggg tcccacccac caccctgctg tgcttgggaa cccccactcc     2520

ccactcccca catcccaaca tcctggtgtc tgtccccagt ggggttggcg tgcatgtgta     2580

catatgtatt tgtgactttt ctttggattt gttttgtgtt tttgttgact agtcctggaa     2640

atgtttgagg ctagacgggg aggggccagg acccacccac tgctcctggg ggatgaggtc     2700

ctggttttaa agccccgtca tttcaagcgg gtcgatcttc cacattcact ggagagactc     2760

tccccacctc tgtctgggtg gggcgcggac ccctcactgt gcgcctgtgc agggggtgct     2820

ggtgcacgtg gcagtgtgga tttccagtgg tcacggtctt actgtttcaa ggtttttaaa     2880

taagaaaacc aaccctgcct tcgcccatgc ccgcccctgc ccgcagttgc caaagagccg     2940

ccttgtcgct gtgggcgtca gggcttggct ggctcagtgc acaacccaca gtggccttca     3000

gaggctcctc ctgggactgg gaaccgccgc agggccaggc ggacggcgtg aggtttgtgt     3060

tggggctggt tctgcccatg ctagggggtg ggggagctcc caggacagac cagccttgtt     3120

tctcatgtaa tgcagtgacg ctgtcattaa acacgtggat tcatgtgtgg                3170


<210> 836
<211> 6283
<212> DNA
<213> Homo sapiens

<400> 836
aaagcgtcct gggtattgta gtgtattgga gggaaggcgt cttggcgcct tctcttcgca       60

ccgttttccg gagactgtta gaggaagagt cgctttttcc tgcctcccag gctgcccagc      120

ggcgccggtt gccggggaac gcaggcgccg tggggaggga tggcgggagg atactgctta      180

ggtgctggag acggagttga gctggtgaag aagagctcgg gctcatcatg aaacaacgaa      240

aaggccaagg gtctgggggc agccgtgggc gcaaaaaaag aggtttaagt gacatttctc      300

catctacaag cctgccacct ctggttgaag gccagctacg ctgttttcta aaacttactg      360

ttaatagagt catatggaag attgcaaagc ctcccacttg tgtacttgtc cgagtgagat      420

ggtggggaga aacatcagat ggaaccctct tttgtcccag ggatgcattg cagactgaac      480

caaaagctgt gagaacaact acacgttacg ctattcgttg tggtccaaaa cagtttacct      540

cttatctaac agatatggct gtgctggtgc tggaagtaat caccaaactt gatggtcttc      600

caattggtag agttcagatc aatggactag ctcaactttc tccaacccat caaatcaatg      660

gattttttac cattgtttca tcaacgtcta agaaacttgg agaactccag gtctcacttg      720

ccctggaacc tctgtcagaa acttacgaca gctaccatcc acttcctacc actgacatga      780

cagaaaatgt gcttttatct aagcagggat tcagagagaa tactgaaccc agcagtaccc      840

agtttcaggt tccatcaagg cctcgcgaca tacataccat caaaattgat ggaaaagagt      900

tagcagccaa cagcagtaga tcaaccactc cgaggggaaa agaccatgta tgctttgcag      960

agaaccctga tacaataaag gattcttcct ttggactaca gcacagtctt aattcaggac     1020

agagtttaga gtctgtaact ctgaaaggca gagctccacg gaagcagatg tcccttctga     1080

acagttctga attccagcct caaattagaa cagttgccaa gagtcacagt gactcatgca     1140

ttctttcttc aaacaacctc cctaccaagg atcttctttc agctctgtta gaacaaggca     1200

ataaactgcg taatgccatg gtgatttctg caatgaaatc aagcccagag accagcatgt     1260

tgttggacca agttcatcct cctattaatg aagattctct tagagcatca acacagatca     1320

gagccttttc taggaatcgg tttaaagacc acattgaaga tcacctcctc ccttcaactg     1380

agaatacatt ttggagacat gacacaaaag ctgataccag agctatacag ctgctattag     1440

gcagtgctga attatcccaa ggcaatttct gggatgggct aggctctcct ccagattccc     1500

catctcctgg gagtgatgtg tattgcatca gtgagctgaa tgaccctcag tatgaccaga     1560

gtcttctgga gaatttattt tatacagcac ctaaatctga taccagcatc agtgatttcc     1620

tcagtgaaga ggatgatatc gtcccttcta aaaaaataag ccagtcaaca gctcttgcca     1680

gatcatctaa ggttctggag tcaagtgatc ataagctgaa gaagaggtca gcaggcaaga     1740

gaaatagaaa tttggttgaa caacagatgc tctcagaaac tccagaagat gcccaaacga     1800

tgacactaag tgtggataga ctggcccttt tgggtagaac acattcagtc agaatcatca     1860

tcgaaaccat gggagttcct ccagatagtc ctcagatgac ccctggcaaa aaaagctatg     1920

ctggtccacc acctaaggtg actacagcaa aaaagcgcac tttctttgta gaatatcact     1980

ttcctgtggg cttttcggaa agcggattgg gaaagacagc tttgatcact gaggttgttc     2040

gactcgcctc cagtaaaatt acagatggaa aggtgaagtt ccagcagcga tttgtgtttc     2100

cagtacagtt tggtggccca atgatagagc actggtggaa ttccaacctc actttccaaa     2160

tttatgtaaa gaaaactcca cagaaaaagc cagaagtcat tggatctgtg tcactttctt     2220

tgcgagctgt cattcaatca gagctgcttt ctttcagtga tcagcttcca gtgcaacaag     2280

aaaatggtca gtctccattt ggccccctca aggtaaccat ggagcttatt acagataaca     2340

aagatttcac tggtatcaat actaagttaa gtggcaacac ccattatacc ccactttgtg     2400

ctcctacaag tccaaataag gcactaccag aacttaacca agatatgacc tgtaccaaaa     2460

atccacaaaa cttaaaccaa attcatgagg aaactgcaaa gaaagcacag aacttggtgc     2520

tccccaaccg aaagtcacca agccctgtag caccacatcc ttcaaccttc gtagctacgc     2580

cagcctccca taatttagtc aatcagacaa atgggacaac aaaagagagt gctttgctgt     2640

tgcatgtgct gttgatggtg ccagatggga aagattttat tagtggagaa tctgagaaac     2700

aatcaccatg caatgtttat ttaaattgta aactcttcag cacagaggaa gtcaccagat     2760

ctgtcatcgc atggggcaca acacaaccgg tctttaactt ttctcaggtg attcctgtct     2820

ctctgtcttc caaatacctg gaaaggctta agaacaatgt gatggtaatt gaaacttgga     2880

ataaggtgcg gagcccagga caggacaagc tgctcgggct ggtgaaactt cccctccacc     2940

agttttacat gtcattcaaa gatgctaaga tttctcgcct gctgctggat gcccagtacc     3000

cagttgttgc tgtcgacagc tacatgcctg tgattgatgt gttttcaggc caccaaaatg     3060

ggagtcttcg agtcttttta gctatgggtt cttcaaatca aataatggca ctacaaagat     3120

taaagaatga agaaggaaca ctccctccct tcagccctag gccagcccat ttcctggacc     3180

agccaactgc agcatctgtt gctatggcag aggaccgagg aaatggactg atggagcact     3240

gctttgagat ccatatagag atggttaaag ggctagcccc tcttcaggca acagtctggg     3300

gagaagcaga ttgttatgtc cagtactact ttccagttca acactctcaa tccagtgtgc     3360

tgaaaggacc tgagttcctt gaaaatggaa ttactctgaa gcccttcaga actgcaacca     3420

cactctgtgt tccagatccc atctttaata gtgaacacca tcactctctc ctgttgccag     3480

ctgaggttcc agtgcaaagg ctcctactaa gtgctttctc tgcacagggc ctcgtgcctg     3540

gaggtggagt ccagtttgaa atctggtgca gatactatta tcctaatgtg agagaccaga     3600

aggtcgccaa aggaaccttg ccattatcaa ggatctgtgc tatggtaacc acccagcatc     3660

gtgaggatgt gggaatacag acctttaatc tccctttaac ccccaggatt gagaacagga     3720

aagaattgag gaaccagtca tcaggtttac tggatgtggg cctaaggtac aggcgtagtc     3780

caagaacagc agagggagtt cttgctgccc gaactgtttc catctcagtc cagattatca     3840

gagcctgtgg tctgcaagca gcagccaagg ctttggctga acgggaaccc gctctacagt     3900

ttagtgccac agtcggggtc aatgcctctg tcaccactca tctctccttc ctgccccagg     3960

gagaacagcg ccgaacccac cctgtggcct gttctttctg ccctgagttc tcccatcacg     4020

ttgagttcac atgtaacttg gtgactcagc actgtagtgg agaggcctgt ttcctagcag     4080

agttgttgga gtttgcagaa gttatttttg ctgtctatca tgaaaatacc aagtcagcaa     4140

gtgatataat cagtattgag tcatgcaaag agtatctgct tggagtagta aaagttccaa     4200

caaaagagct gctgatcaag agatctggga tcacaggatg gtatcctatc attttaccag     4260

aagacggggg cctacctcat ggcctggagc tcatgcagaa gatcgtgggt ggtctggagc     4320

tttcgatttc cttcacgcat cgtggagata gagaacgggt gttggaagct gctgagcatt     4380

tgggctggag ctttgagaac agcctgaaag attttgtcag aatggatgaa ggggagccag     4440

ccactgtcac catctccacc ccaaggctgt ggctgcccat ccattgtgtg ctgcttgctg     4500

gccacaacca cattcataag aatacatatt gctaccttcg ctacaagttc tatgatcatg     4560

aagccttttg gacccctctc aagaagccta aggaatctgt aaacaaaaag cagattatgg     4620

tcactttcaa ggcatccaaa agagcagaag tcaccagggg cccatcactg ctttggtact     4680

tcagggagga gaggctagag atccaagtgt ggcgagctta tggcaatgac agtgtggaga     4740

gaccccatca gacagacagc tggattggct cagcctatgt ggacctggcc agacttgggg     4800

agaggtcagc gaggacgcta actgtcagtg gtgtgtatcc tctgtttgga cgaaatgctt     4860

ccaacctctc aggagctgcc ttgcgagttc atgtggttct ttcctctctt tcctcacacc     4920

ttgagcccac tcatgagctg gactccatgg actgcagcag ccacagtgag tctgagcagc     4980

tccccagaag gaatgatgag gtccagctct ctccaccaga agtcatctcc tgccaccaga     5040

agtctcctgc ctccacccag gtcccctgca gcagcaccac agctgaagtc cgcctgacgc     5100

aggagggccc tgctgatttg gatggaacgt ttgcagtcag catcctagta gaaagagcaa     5160

tgcacttgag cttgaaaggg agccccttga cagagcggaa agtatcgata cccagttgtt     5220

gtgtatcctt tgcaacagcc gatgagtcat ctcctgtata cacccaagtg gttgaaaaca     5280

cagattcccc catctggaat tttcaacagc agtcaaggct atcaaaagag ctgcttctgg     5340

acccacaaca aaccctggtc ttcaaagttt ggcataaagg agatgaggag agggtgattg     5400

gctttgcctc ggtggacctc tccccacttc tctctggctt ccagtttgtc tgtggctggt     5460

acaacatcac agacttcagt ggagagtgcc aggggcagat aaaagttgct gtctcccctt     5520

tggagagttt gatacacttc aaagaagaaa ggcaagcaag gcgtggagtg gagacctcaa     5580

aatcactgat cccaatatac agtccctttt ccttccctgc ctctgatacg tatgctgcat     5640

tctccagcca catggcaagg cagaccctag accaacttgc tcatgcctcc tcaaaggagc     5700

ttgatttctc ctctcctggg agaagtgata ccacaagaag ccaagcatca cgccatgaag     5760

agcatgtgca gaacattcgc cggtttcatg aatccctgca tcttcaggga gaggcaccct     5820

tgccatgtga tgacaaactg accacatcac ctttgtcctc ccaaacctcc attctgactt     5880

ctctcaggaa gaatctgagt gagcttgatc agattcagag gtacttccgc cagaagctca     5940

ccaagccttt cctacccctc agccctcaga ctcaaacggc catctcacag caccaggaga     6000

gctgtaggga ccatcttggg ccaggtgcca gcagcctaga ccctgggagc cagtgtatcc     6060

tggagaaatc cagtaacctg gtgttgcaag tcagctcctt aatcacaggt agttactgaa     6120

gtaactggaa gcatgaacat gcccaccagg actcccagct cccaacgatt cctgagcatg     6180

agcagatagt ctctgaaagc atttccacag atgtatccac aactatagat tagattctgg     6240

tcctctgata ttagaataaa gtactaaaaa ttgtaccgcc ttg                       6283


<210> 837
<211> 6225
<212> DNA
<213> Homo sapiens

<400> 837
aaagcgtcct gggtattgta gtgtattgga gggaaggcgt cttggcgcct tctcttcgca       60

ccgttttccg gagactgtta gaggaagagt cgctttttcc tgcctcccag gctgcccagc      120

ggcgccggtt gccggggaac gcaggcgccg tggggaggga tggcgggagg atactgctta      180

ggtgctggag acggagttga gctggtgaag aagagctcgg gctcatcatg aaacaacgaa      240

aaggccaagg gtctgggggc agccgtgggc gcaaaaaaag aggtttaagt gacatttctc      300

catctacaag cctgccacct ctggttgaag gccagctacg ctgttttcta aaacttactg      360

ttaatagagt catatggaag attgcaaagc ctcccacttg tgtacttgtc cgagtgagat      420

ggtggggaga aacatcagat ggaaccctct tttgtcccag ggatgcattg cagactgaac      480

caaaagctgt gagaacaact acacgttacg ctattcgttg tggtccaaaa cagtttacct      540

cttatctaac agatatggct gtgctggtgc tggaagtaat caccaaactt gatggtcttc      600

caattggtag agttcagatc aatggactag ctcaactttc tccaacccat caaatcaatg      660

gattttttac cattgtttca tcaacgtcta agaaacttgg agaactccag gtctcacttg      720

ccctggaacc tctgtcagaa acttacgaca gctaccatcc acttcctacc actgacatga      780

cagaaaatgt gcttttatct aagcagggat tcagagagaa tactgaaccc agcagtaccc      840

agtttcaggt tccatcaagg cctcgcgaca tacataccat caaaattgat ggaaaagagt      900

tagcagccaa cagcagtaga tcaaccactc cgaggggaaa agaccatgta tgctttgcag      960

agaaccctga tacaataaag gattcttcct ttggactaca gcacagtctt aattcaggac     1020

agagtttaga gtctgtaact ctgaaaggca gagctccacg gaagcagatg tcccttctga     1080

acagttctga attccagcct caaattagaa cagttgccaa gagtcacagt gactcatgca     1140

ttctttcttc aaacaacctc cctaccaagg atcttctttc agctctgtta gaacaaggca     1200

ataaactgcg taatgccatg gtgatttctg caatgaaatc aagcccagag accagcatgt     1260

tgttggacca agttcatcct cctattaatg aagattctct tagagcatca acacagatca     1320

gagccttttc taggaatcgg tttaaagacc acattgaaga tcacctcctc ccttcaactg     1380

agaatacatt ttggagacat gacacaaaag ctgataccag agctatacag ctgctattag     1440

gcagtgctga attatcccaa ggcaatttct gggatgggct aggctctcct ccagattccc     1500

catctcctgg gagtgatgtg tattgcatca gtgagctgaa tgaccctcag tatgaccaga     1560

gtcttctgga gaatttattt tatacagcac ctaaatctga taccagcatc agtgatttcc     1620

tcagtgaaga ggatgatatc gtcccttcta aaaaaataag ccagtcaaca gctcttgcca     1680

gatcatctaa ggttctggag tcaagtgatc ataagctgaa gaagaggtca gcaggcaaga     1740

gaaatagaaa tttggttgaa caacagatgc tctcagaaac tccagaagat gcccaaacga     1800

tgacactaag tgtggataga ctggcccttt tgggtagaac acattcagtc agaatcatca     1860

tcgaaaccat gggagttcct ccagatagtc ctcagatgac ccctggcaaa aaaagctatg     1920

ctggtccacc acctaaggtg actacagcaa aaaagcgcac tttctttgta gaatatcact     1980

ttcctgtggg cttttcggaa agcggattgg gaaagacagc tttgatcact gaggttgttc     2040

gactcgcctc cagtaaaatt acagatggaa aggtgaagtt ccagcagcga tttgtgtttc     2100

cagtacagtt tggtggccca atgatagagc actggtggaa ttccaacctc actttccaaa     2160

tttatgtaaa gaaaactcca cagaaaaagc cagaagtcat tggatctgtg tcactttctt     2220

tgcgagctgt cattcaatca gagctgcttt ctttcagtga tcagcttcca gtgcaacaag     2280

aaaatggtca gtctccattt ggccccctca aggtaaccat ggagcttatt acagataaca     2340

aagatttcac tggtatcaat actaagttaa gtggcaacac ccattatacc ccactttgtg     2400

ctcctacaag tccaaataag gcactaccag aacttaacca agatatgacc tgtaccaaaa     2460

atccacaaaa cttaaaccaa attcatgagg aaactgcaaa gaaagcacag aacttggtgc     2520

tccccaaccg aaagtcacca agccctgtag caccacatcc ttcaaccttc gtagctacgc     2580

cagcctccca taatttagtc aatcagacaa atgggacaac aaaagagagt gctttgctgt     2640

tgcatgtgct gttgatggtg ccagatggga aagattttat tagtggagaa tctgagaaac     2700

aatcaccatg caatgtttat ttaaattgta aactcttcag cacagaggaa gtcaccagat     2760

ctgtcatcgc atggggcaca acacaaccgg tctttaactt ttctcaggtg attcctgtct     2820

ctctgtcttc caaatacctg gaaaggctta agaacaatgt gatggtaatt gaaacttgga     2880

ataaggtgcg gagcccagga caggacaagc tgctcgggct ggtgaaactt cccctccacc     2940

agttttacat gtcattcaaa gatgctaaga tttctcgcct gctgctggat gcccagtacc     3000

cagttgttgc tgtcgacagc tacatgcctg tgattgatgt gttttcaggc caccaaaatg     3060

ggagtcttcg agtcttttta gctatgggtt cttcaaatca aataatggca ctacaaagat     3120

taaagaatga agaaggaaca ctccctccct tcagccctag gccagcccat ttcctggacc     3180

agccaactgc agcatctgtt gctatggcag aggaccgagg aaatggactg atggagcact     3240

gctttgagat ccatatagag atggttaaag ggctagcccc tcttcaggca acagtctggg     3300

gagaagcaga ttgttatgtc cagtactact ttccagttca acactctcaa tccagtgtgc     3360

tgaaaggacc tgagttcctt gaaaatggaa ttactctgaa gcccttcaga actgcaacca     3420

cactctgtgt tccagatccc atctttaata gtgaacacca tcactctctc ctgttgccag     3480

ctgaggttcc agtgcaaagg ctcctactaa gtgctttctc tgcacagggc ctcgtgcctg     3540

gaggtggagt ccagtttgaa atctggtgca gatactatta tcctaatgtg agagaccaga     3600

aggtcgccaa aggaaccttg ccattatcaa ggatctgtgc tatggtaacc acccagcatc     3660

gtgaggatgt gggaatacag acctttaatc tccctttaac ccccaggatt gagaacagga     3720

aagaattgag gaaccagtca tcaggtttac tggatgtggg cctaaggtac aggcgtagtc     3780

caagaacagc agagggagtt cttgctgccc gaactgtttc catctcagtc cagattatca     3840

gagcctgtgg tctgcaagca gcagccaagg ctttggctga acgggaaccc gctctacagt     3900

ttagtgccac agtcggggtc aatgcctctg tcaccactca tctctccttc ctgccccagg     3960

gagaacagcg ccgaacccac cctgtggcct gttctttctg ccctgagttc tcccatcacg     4020

ttgagttcac atgtaacttg gtgactcagc actgtagtgg agaggcctgt ttcctagcag     4080

agttgttgga gtttgcagaa gttatttttg ctgtctatca tgaaaatacc aagtcagcaa     4140

gtgatataat cagtattgag tcatgcaaag agtatctgct tggagtagta aaagttccaa     4200

caaaagagct gctgatcaag agatctggga tcacaggatg gtatcctatc attttaccag     4260

aagacggggg cctacctcat ggcctggagc tcatgcagaa gatcgtgggt ggtctggagc     4320

atttgggctg gagctttgag aacagcctga aagattttgt cagaatggat gaaggggagc     4380

cagccactgt caccatctcc accccaaggc tgtggctgcc catccattgt gtgctgcttg     4440

ctggccacaa ccacattcat aagaatacat attgctacct tcgctacaag ttctatgatc     4500

atgaagcctt ttggacccct ctcaagaagc ctaaggaatc tgtaaacaaa aagcagatta     4560

tggtcacttt caaggcatcc aaaagagcag aagtcaccag gggcccatca ctgctttggt     4620

acttcaggga ggagaggcta gagatccaag tgtggcgagc ttatggcaat gacagtgtgg     4680

agagacccca tcagacagac agctggattg gctcagccta tgtggacctg gccagacttg     4740

gggagaggtc agcgaggacg ctaactgtca gtggtgtgta tcctctgttt ggacgaaatg     4800

cttccaacct ctcaggagct gccttgcgag ttcatgtggt tctttcctct ctttcctcac     4860

accttgagcc cactcatgag ctggactcca tggactgcag cagccacagt gagtctgagc     4920

agctccccag aaggaatgat gaggtccagc tctctccacc agaagtcatc tcctgccacc     4980

agaagtctcc tgcctccacc caggtcccct gcagcagcac cacagctgaa gtccgcctga     5040

cgcaggaggg ccctgctgat ttggatggaa cgtttgcagt cagcatccta gtagaaagag     5100

caatgcactt gagcttgaaa gggagcccct tgacagagcg gaaagtatcg atacccagtt     5160

gttgtgtatc ctttgcaaca gccgatgagt catctcctgt atacacccaa gtggttgaaa     5220

acacagattc ccccatctgg aattttcaac agcagtcaag gctatcaaaa gagctgcttc     5280

tggacccaca acaaaccctg gtcttcaaag tttggcataa aggagatgag gagagggtga     5340

ttggctttgc ctcggtggac ctctccccac ttctctctgg cttccagttt gtctgtggct     5400

ggtacaacat cacagacttc agtggagagt gccaggggca gataaaagtt gctgtctccc     5460

ctttggagag tttgatacac ttcaaagaag aaaggcaagc aaggcgtgga gtggagacct     5520

caaaatcact gatcccaata tacagtccct tttccttccc tgcctctgat acgtatgctg     5580

cattctccag ccacatggca aggcagaccc tagaccaact tgctcatgcc tcctcaaagg     5640

agcttgattt ctcctctcct gggagaagtg ataccacaag aagccaagca tcacgccatg     5700

aagagcatgt gcagaacatt cgccggtttc atgaatccct gcatcttcag ggagaggcac     5760

ccttgccatg tgatgacaaa ctgaccacat cacctttgtc ctcccaaacc tccattctga     5820

cttctctcag gaagaatctg agtgagcttg atcagattca gaggtacttc cgccagaagc     5880

tcaccaagcc tttcctaccc ctcagccctc agactcaaac ggccatctca cagcaccagg     5940

agagctgtag ggaccatctt gggccaggtg ccagcagcct agaccctggg agccagtgta     6000

tcctggagaa atccagtaac ctggtgttgc aagtcagctc cttaatcaca ggtagttact     6060

gaagtaactg gaagcatgaa catgcccacc aggactccca gctcccaacg attcctgagc     6120

atgagcagat agtctctgaa agcatttcca cagatgtatc cacaactata gattagattc     6180

tggtcctctg atattagaat aaagtactaa aaattgtacc gcctt                     6225


<210> 838
<211> 1968
<212> DNA
<213> Homo sapiens

<400> 838
attgtcgctt tcgctacccg cggggccggg cgagcgggaa gctcggcaca gtgggagcct       60

ggtggtgggt ctcctggggc cggtcgcaat gggtttccgg gggtcccgcg gctgctctgt      120

ggaccccttc ggcccctggt gctccgggcg ctggcagcgt caccggacaa aggccaccga      180

gcgcgggggt gtccccgagg tggacgcgcg ggtttacttc ctctccggcc ccacgggcgc      240

gcttccctcc tgacggattc cgaagcccgc cccaccaccg tcaccgcacc agtggcccag      300

gcttcgtggg accaacaggg ctaatcctgc cccacggatc taatccggat cgggacccgg      360

tcccagggga ggcccccacc tccccttcta ttgttctgtg gcccaggttc cggagcattt      420

gctccatgcc ctcgcctgcc tgcagggccc cggtgtggcc ccggtgctgc gctgcgcgcc      480

gacccccgcg ggtctgtctc tccaactgca gcggtccgcc gtcttcgagc gcgtcctcag      540

cgccgtggcc gcctatgcca cgcccgcctc gcctgcctcg ctgggccagc gcgtcttact      600

acactgccca gcactgcgca gctccccctg cgcactccgc ttgagccagc tgcgtacggt      660

gctcgtggcc gatcacctgg cgcgagccct gcgcgctcac ggggtgtgcg tgcgcctagt      720

gccagctgtg cgggatccgc acatgctgac cttcctgcag caactgcggg tggactggcc      780

cgctgcctcg gagagagctt cctcccacac cctgaggagc cacgcccttg aagaacttac      840

ctctgctaat gacgggagga cactgtcccc tggcatccta ggcagactgt gtctgaagga      900

gctggtggaa gaacagggcc gcacagctgg ctatgacccc aacctggaca actgtctggt      960

gactgaggat ctcctctctg tgctggctga gctgcaagag gctctatggc attggcccga     1020

ggacagccac ccaggcctgg ctggggcctc agatactggt acaggcggct gcctggttgt     1080

acatgttgtt agctgtgagg aggagttcca gcaacagaag ttggacctgc tttggcagaa     1140

gttggttgac aaggctccac tcagacagaa gcacctcatc tgtggccctg tgaaagtagc     1200

tggtgcacct ggcactctga tgactgcccc tgagtactac gagttccggc atacccaggt     1260

gtgcaaggcc tcagcactga agcatggtgg ggatctggca caagacccag cctggacaga     1320

gatctttggt gttctctctg tggccaccat caagtttgag atgctgagca cagccccaca     1380

gagtcagctc ttcctggctc tggctgacag cagtatctcc acgaagggca caaagagtgg     1440

cacctttgtc atgtataatt gtgcccgtct tgccacactc tttgagagtt acaagtgtag     1500

tatggaacaa ggtctgtacc ccacttttcc tcctgtgagc agtctggact tctcactgct     1560

acatgatgag ggtgagtggt tgttgctctt caacagtatc ctcccctttc cggatctgct     1620

gagccggaca gcagtgctgg actgcacagc cccggggctc cacattgctg tacgcacaga     1680

gatgatatgc aagttcctgg tacagctcag catggatttc agctcctact acaaccgggt     1740

acacatcctg ggggagcctc gaccacacct ctttggtcag atgttcgtcc gcctgcagct     1800

tctgagagct gtgcgtgagg tgctccatac tggcctggct atgctgggtc tccctccact     1860

gagccacatt taaggccaca gaggctccaa tacctgggaa tgttcacaaa gtcatcaact     1920

ggaaaaaaag caaaaaccca cggccaaaat aaattggtac tgtttgtt                  1968


<210> 839
<211> 2151
<212> DNA
<213> Homo sapiens

<400> 839
gtgtttcacc acacggagat gtggtcacgt gacttgtcaa ctttcaccca ggatgtctcc       60

cttctgactt ccccttagca accaagtcgc ggcgcttggt tccccagcaa ccgggagacg      120

cgtctgctgc gtggaaccgc cgagttccca gcgcttgaga agggtcttcc tatgttgccc      180

gggctggtct tgaactcctg aactcaagca gtccttccac ctcggcctcc caaagagctg      240

ggattacagg tgaaaattct ggatctgtta tctgtgagga ggccactccg ttgacagttg      300

tgtaaaactc tgctgctttc cccagctcca acctctctgg tcttcaacaa cactatcatc      360

agggaaaacg tgggggaaga tgaaccagcc gtgcaactcg atggagccga gggtgatgga      420

cgatgacatg ctcaagctgg ccgtcgggga ccagggcccc caggaggagg ccgggcagct      480

ggccaagcag gagggcatcc tcttcaagga tgtcctgtcc ctgcagctgg actttcggaa      540

catcctccgc atagacaacc tctggcagtt tgagaacttg aggaagctgc agctggacaa      600

taacatcatt gagaagatcg agggcctgga gaacctcgca cacctggtct ggctggatct      660

gtctttcaac aacattgaga ccatcgaggg gctggacaca ctggtgaacc tggaggacct      720

gagcttgttc aacaaccgga tctccaagat cgactccctg gacgccctcg tcaagctgca      780

ggtgttgtcg ctgggcaaca accggattga caacatgatg aacatcatct acctccggcg      840

gttcaagtgc ctgcggacgc tcagcctctc taggaaccct atctctgagg cagaggatta      900

caagatgttc atctgtgcct accttcctga cctcatgtac ctggactacc ggcgcattga      960

tgaccacaca aaaaagcttg cggaggctaa gcaccagtac agcatcgacg agctgaagca     1020

ccaggagaac ctgatgcagg cccagctgga ggacgagcag gcgcagcggg aggagctaga     1080

gaagcacaag actgcgtttg tggaacacct gaatggctcc ttcctgtttg acagcatgta     1140

cgctgaggac tcagagggca acaatctgtc ctacctgcct ggtgtcggtg agctccttga     1200

gacctacaag gacaagtttg tcatcatctg cgtgaatatt tttgagtatg gcctgaaaca     1260

gcaggagaag cggaaaacag agcttgacac cttcagtgaa tgtgtccgtg aggccatcca     1320

ggaaaaccag gagcagggca aacgcaagat tgccaaattc gaggagaagc acttgtcgag     1380

tttaagtgcc attcgagagg agttggaact gcccaacatt gagaagatga tcctagaatg     1440

cagtgctgac atcagtgagt tgttcgatgc gctcatgacg ctggagatgc agctggtgga     1500

gcagctggag gagactataa acatgtttga aaggaacatt gttgacatgg taggactgtt     1560

tatcgaaaat gtccaaagcc tgatggctca gtgccgggac ctggagaatc accaccacga     1620

gaagctcctg gagatctcta tcagcaccct ggagaagatt gtcgagggcg acctggacga     1680

ggacctgcct aacgacctgc gcgcgctttt tgtcgataaa gatacgattg ttaatgctgt     1740

cggggcatcg cacgacatcc acctcctgaa gattgacaat cgagaagatg agctggtgac     1800

cagaatcaac tcttggtgta cacgtttaat agacaggatt cacaaggatg agatcatgag     1860

gaaccgcaag cgcgtgaagg agatcaatca gtacatcgac cacatgcaga gcgaactgga     1920

caacctggaa tgtggcgaca tcctagacta gatgaatgtc agccacagga gcttcttcaa     1980

aacatagcac cagccccagc caggagaagg aagtgcacac gcctcacccg cacctctaga     2040

gagttgctgg gcatctctca accgcgatcc ccaacaccat tcttccccca cccctggaaa     2100

aacttccaaa agtagagaaa ataaaggact catttcacat ttcccctact c              2151


<210> 840
<211> 2292
<212> DNA
<213> Homo sapiens

<400> 840
ggcctgcggc gcgcgggaag cggcgcgcgc tgcgcgggag gtgacggtgc ctctgactgt       60

ccgggtccct ccagcatttt gcagctttct cctgtcttga agaagtagaa cggtgcccga      120

gaaacgtttt tccccttcga gactcaggag gatgaaagtc atcacttgtg aaatagcctg      180

gcacaacaag gagcccgtgt acagcctgga cttccagcat gggacggctg ggaggatcca      240

cagactggcg tctgccggcg tggacaccaa tgtcaggatc tggaaggtag aaaagggacc      300

agatggaaaa gccatcgtgg aatttttgtc caatcttgct cgtcatacca aagccgtcaa      360

tgttgtgcgt ttttctccaa ctggggaaat tttagcatcg ggaggagatg atgctgtcat      420

cctattgtgg aaggtgaatg ataacaagga gccggagcag atcgcttttc aggatgagga      480

cgaggcccag ctgaacaagg agaactggac ggttgtgaag actctgcggg gccacttaga      540

agatgtgtat gatatttgct gggcaactga tgggaattta atggcttctg cctctgtgga      600

taacacagcc atcatatggg atgtcagcaa aggacaaaag atatcaattt ttaatgaaca      660

taaaagttat gtccaaggag taacctggga ccctttgggt caatatgttg ctactctgag      720

ctgtgacagg gtgctgcgag tatacagtat acagaagaag cgtgtggctt tcaatgtttc      780

gaagatgctg tctggaatag gggctgaagg agaggcaaga agctaccgga tgtttcacga      840

cgacagcatg aagtctttct tccgtagact gagtttcact cccgacggat ctttgcttct      900

cacgccagct ggatgtgtgg aatctggtga aaatgtaatg aataccactt atgttttctc      960

caggaagaat cttaaaaggc ccatcgctca tcttccatgt cctggaaaag ccactcttgc     1020

tgttcgctgc tgtccggtct actttgaact gaggccagtg gtggaaacag gtgtggagct     1080

gatgagtctg ccctaccgcc tggtgtttgc tgtggcctcg gaggattccg tgcttctgta     1140

tgacacccag cagtccttcc cttttggtta cgtgtctaat atacattacc acaccctcag     1200

tgacatttca tggtccagcg atggtgcctt cctggccatt tcttccacgg acggttactg     1260

ctcatttgtg acatttgaga aagatgaact tggaattcct ttgaaagaga agccagtttt     1320

gaacatgaga actcctgata cagcaaagaa aaccaagagt cagacacatc gagggtcttc     1380

gccaggaccc agaccggtag agggaacccc tgccagcaga acccaagacc ccagcagccc     1440

cggcacgact ccccctcagg ccagacaggc cccagcccca acagtcatca gggaccctcc     1500

ctccatcact cctgctgtca aaagcccctt gccggggcct tcggaggaga agaccctgca     1560

gcccagtagt caaaacacaa aagcccaccc atcccggagg gtcactctga acacactgca     1620

agcctggagc aagacaacac cccggagaat aaacttaaca cccttaaaga cggacactcc     1680

accaagttct gtaccaacca gtgtgatttc caccccttct acagaagaaa ttcagtcaga     1740

gacgcctgga gacgctcagg gcagtccccc agagctaaag cggcccagac tcgatgaaaa     1800

caaaggaggc acggaaagtc tggacccttg atgggacctc ggcttctgct cgaagcctac     1860

caggctcccg gtgtgtgcag ggagacggta aagctggagg tgcctgagac cagggcttcc     1920

atggagcggg acacactgta aatggatttc tataacagaa gtgacatgtg tactgatttt     1980

tctccagaaa tatggatgct gttgtattca gtatccattt ttaacttggg acatgaacgt     2040

tttaacgtag taaatcctct ttttgatgag tttctgaaac tggagcggtt caacgttatc     2100

cagtgtgaaa atcagtgagt cctccctggc atcctcgtga aagtgcacac acttcatgga     2160

gggactcctt ttcaataaga attaggaaga tgagaaagta atttgagatt ttactctgtc     2220

gaattttaga gtatttgaag tgattgttag atttcacttc taaggagttg attgattaaa     2280

ctttggaagg ta                                                         2292


<210> 841
<211> 1853
<212> DNA
<213> Homo sapiens

<400> 841
ccccccgccc acccgggccc ggacacgctg agcacactgg aaggagtcat ggcggatggt       60

caggtggcgg aactgctgct ccggcggctg gaggcgtctg atggcggcct ggacagcgcc      120

gagttggcgg ctgagctggg catggagcac caggcggtgg tgggcgccgt gaagagcctt      180

caggcgctgg gcgaggtcat cgaggctgaa cttcggtcca ccaagcactg ggagcttact      240

gcggagggcg aggagattgc ccgggagggc agccatgagg cccgtgtgtt tcgaagcatt      300

cccccagagg gcctggccca gagcgagctt atgcgactgc ccagtggcaa agtgggcttc      360

agcaaggcca tgtccaacaa gtggattcgg gtggacaaga gtgcggctga cgggccccgg      420

gtgttccgag tggtggacag catggaggat gaggtgcagc ggcggctcca gctggtccgg      480

gggggacagg ctgagaagct gggggagaag gagaggagcg agctgaggaa gaggaagctg      540

ttggctgaag tgactctgaa gacctactgg gtgagcaaag gcagtgcctt tagtaccagc      600

atctccaagc aagagacaga gctgagccca gagatgatct ccagtggctc ttggcgggac      660

cggcccttca agccctacaa cttcttggcc cacggtgtcc tccccgacag cggccacctt      720

cacccgctgc tcaaggtccg ctcccagttc cgacagatct tcctggagat ggggttcacc      780

gagatgccga ctgataactt cattgagagc tccttctgga actttgacgc cctcttccag      840

ccccagcagc acccagcccg tgaccagcac gacaccttct tccttcgaga tccagcggag      900

gccctgcagc tcccaatgga ctatgtccag cgggtcaagc ggacccactc tcagggcggc      960

tacggctcac aggggtacaa gtataactgg aagctggacg aggcccggaa aaacctactg     1020

cgaacccaca ccacatcagc cagcgcccgt gcgctctacc gccttgccca gaagaagccc     1080

ttcactccgg tcaagtactt ctccatcgac cgcgtattcc ggaatgagac cctggacgcc     1140

acgcacctgg ctgagttcca ccagatcgag ggcgtggtgg cggatcatgg tctcaccttg     1200

ggccacctca tgggcgttct gcgggagttc ttcaccaagc tgggtatcac gcaactccgc     1260

ttcaagccag cctacaaccc atacacagag cccagcatgg aggtgttcag ctaccaccaa     1320

ggcctgaaga agtgggtgga ggtcggaaac tcgggggtct tccgtccaga gatgctgctg     1380

cccatggggc ttcccgagaa cgtgtcggtc attgcctggg gcctctccct ggagcgccca     1440

acgatgatca aatatggcat caacaatatc cgggagctgg tgggccacaa ggtgaacctg     1500

cagatggtgt atgacagtcc cctgtgccgc ctggatgccg agccgaggcc ccctcccaca     1560

caggaggctg cgtgacatgg gccactctag gacaggtcat cctccccgag tccctgctgc     1620

tgcgctcctt tgcatccctg gccagtgacc ttgtatttat gaggcctctg tgaggccagc     1680

ccccaccttc ctctttccca cctgtcccag gaccagaatc ccagggacag aggactgggt     1740

agcaggttcc ttctgttgtc ctgtgtggtg tgtctactgt gagggtgggc cctgaggaga     1800

cctgtgggcc acctattgtc taataaagtg ggcagttgcc cccatctggt ggc            1853


<210> 842
<211> 2254
<212> DNA
<213> Homo sapiens

<400> 842
gacaacaaga tggcggcgct gcgggacggc tagcggccct gcgtgggagt tcctgacagc       60

tggattctag aagtagaact atgagctcac ctttggcctc ccttagcaag acccgaaaag      120

tgcccctgcc ctcggagcct atgaatcctg ggaggcgagg aatccgcatc tatggagatg      180

aagatgaggt ggacatgttg agtgatgggt gtggctcaga agaaaagatc tcagtccctt      240

cctgctatgg cggcataggt gcccctgtga gtcggcaagg ggactcattg gcgccccctg      300

aggtggactt tgacaggctg ctggccagcc tgcaggatct tagtgagctg gtggtagagg      360

gtgacaccca agtgacacca gtgcccggcg gggcacggct gcgtaccctc gagcccatcc      420

cgctgaagct ctaccggaat ggcatcatga tgttcgacgg gcccttccag cccttctacg      480

atccctccac acagcgctgc ctccgagaca tattggatgg cttctttccc tcagagctcc      540

agcgactgta ccccaatggg gtccccttta aggtgagtga cttgcgcaat caggtctacc      600

tggaggatgg actggacccc ttcccaggcg agggccgtgt ggtgggcagg cagctgatgc      660

acaaggcctt ggacagggtg gaggagcacc caggctccag gatgactgct gagaaatttc      720

tgaacaggct ccccaagttt gtgatccggc aaggcgaggt gattgacatc cggggcccca      780

tcagggacac cttgcagaac tgctgcccat tgcctgcccg gatccaggag attgtggtgg      840

agacgcccac cttggccgct gagcgagaga ggagccagga gtcacccaac acgccggcac      900

ccccgctctc catgctgcgc atcaagtctg agaatgggga acaggccttc ctactgatga      960

tgcagcctga caacaccatt ggggacgtgc gagctctgct agcgcaggcc agggtcatgg     1020

atgcctctgc ctttgagatc ttcagcacat tcccgcccac cctctaccag gacgatacac     1080

tcacgctgca ggctgcaggc cttgtgccca aagcagcact gctgctgcgg gcacgccgag     1140

ccccgaagtc cagcctgaaa ttcagtcctg gtccctgtcc cggtcccggt cccggcccca     1200

gtcccggtcc cggtcccggc cccagtcccg gtcccggtcc cggccccagt ccctgtcctg     1260

gacccagtcc cagcccccaa taaagcaccc gccccctcaa cccgctgctc cgccaggctc     1320

ttgggtgggc catctcgcca ggcacgtagg aaaggcctgg gaccagctgg gccagggagg     1380

gggcggtgcc gacccgcccc ttggtaactc gagccccggc tggcgggcct ggctgctggg     1440

tctttgtctt ctaggttcct ctttctccca agaagggcta agtggatcct gtgaagggag     1500

ggatgcagtg gggggaagga gctggcccca gctgggttta cattctcagc tgggacagca     1560

gagcctcact gtgtatgtgt gcagccagca gatacctgtg cacaggcaca gacccaccaa     1620

ctcgtgggga cacttcaaca ccgcacaaag ccattttgcc actagaccca tgcccccaaa     1680

ttagcagaac tgcagctggg tacccacctc ccatgataca ctcattctta gccattgtgc     1740

tccaacacag gcgcatggga tggccacact cactgacagg catggagatg tgcactacac     1800

accaaggcac aagcatgata tggacacatg catgtgaact ggagggtggc ccacccagac     1860

atctccagaa accactggtc catacaggta tttgtgtgtc agacatatcc aaacacatgc     1920

actaacaaac acagaggtga cagtcacaag agaacagctc agccaccctt cccacagagc     1980

agtctcagca cagtcacaac taccaacctt gcccagggca gggacccagg aggcccaggc     2040

cacaaccaac cagacacagt gccaatggaa caggacatca tttaattgcc tctagggtcc     2100

tcctgggaga gggactgcgg ggcctttggc agagctctgg ctgatggaac caacagaggt     2160

gcccatcagc cagtgccagg caggatggcg gccccaatgc ttggctgggg gcagccagca     2220

tttggggctg ttgcttaaga caatttctga gact                                 2254


<210> 843
<211> 1536
<212> DNA
<213> Homo sapiens

<400> 843
gacacaggaa actcccctga aacctgtttc tcagcttccc ggcccagctg gggcacccac       60

tggaaggaga ggccaggcgg aagaccctgg ctccgtcatg gcctctgccc tgaggccacc      120

ccgtgtcccc aagcctaagg gtgtcctgcc ttcacactac tatgagagct ttctagagaa      180

gaaggggccc tgtgaccggg attacaagaa gttctgggca ggcctgcagg gtctcaccat      240

ttatttctac aatagcaatc gggacttcca gcacgtggag aagctcaact tgggagcatt      300

tgagaaactc acagatgaga ttccctgggg aagctcacgt gaccctggca cccacttcag      360

cctgattctc cgggatcagg agatcaagtt caaggtagag accttggagt gtcgggaaat      420

gtggaaaggc ttcatcttaa cggtggtgga gctccgtgtc ccgaccgact tgaccctgct      480

tcctgggcac ctatacatga tgtctgaagt cttggccaaa gaggaggcgc gccgtgcact      540

ggagacaccc tcgtgcttcc tgaaggtgag ccggctggag gcacaactgc tcctggagcg      600

ctaccccgag tgcgggaacc tgctgctgcg gcccagcggg gacggcgccg acggcgtgtc      660

ggtcaccacg cggcagatgc acaacgggac gcacgtggtc cggcattaca aggtgaagcg      720

ggagggcccc aagtacgtga tcgatgtgga acagccgttc tcttgcacct ccctggacgc      780

cgtggtcaac tatttcgtgt cgcataccaa aaaggcgctg gtgccattcc tgttagacga      840

ggactacgag aaggtgctag gctacgtgga agccgataag gagaatggcg agaatgtgtg      900

ggtggcgccc tccgctccgg gcccaggtcc tgcaccctgc acaggtggcc ccaagccgct      960

gtcacctgcg tctagccagg acaagctgcc cccactgccc ccactaccga accaggaaga     1020

gaactacgtg acccccattg gagatggccc agctgttgac tatgagaacc aagatgtggc     1080

ttcctctagt tggccagtca tcctgaagcc aaagaagttg ccaaagcctc ctgccaagct     1140

tccaaagcca cccgttggac ccaagccagt agagaagggg tttcaccatg ttgcccaggc     1200

tggtctcgaa ctcctgacct caagtgatcc acccacctca gcctcccaaa gtgctgggat     1260

taccggcgtg agccaccaca cctggcctca tctgtcttct cttccagagc ccaaagtctt     1320

taatggtggc ttgggcagga agctgccagt cagttcagcc cagcctctct tccccacagc     1380

cgggctggca gacatgacgg cagagctaca gaagaagctg gagaagaggc gggcactgga     1440

gcactgattc ggacacacca gggaccagcg ggctagtccc agggcatggc ccagcggcca     1500

gattcttttt cccaggatta aaactctgac cccagg                               1536


<210> 844
<211> 2919
<212> DNA
<213> Homo sapiens

<400> 844
gagaggactg cgcctgcgca gagccgagga cgcgtccggc gccgagattc aaactagtgg       60

cgggaggctg tgagctgagc ggtggggtct gcgtacgcct ggagtccttc cccgctgtgc      120

tcagcatgga ccctatccgg agcttctgcg ggaagctgcg gtctctggcc agcacgctgg      180

actgcgagac ggcccggctg cagcgagcgc tggacggaga ggaaagcgac tttgaagatt      240

atccaatgag aattttatat gaccttcatt cagaagttca gactctaaag gatgatgtta      300

atattcttct tgataaagca agattggaaa atcaagaagg cattgatttc ataaaggcaa      360

caaaagtact aatggaaaaa aattcaatgg atattatgaa aataagagag tatttccaga      420

agtatggata tagtccacgt gtcaagaaaa attcagtaca cgagcaagaa gccattaact      480

ctgacccaga gttgtctaat tgtgaaaatt ttcagaagac tgatgtgaaa gatgatctgt      540

ctgatcctcc tgttgcaagc agttgtattt ctgagaagtc tccacgtagt ccacaacttt      600

cagattttgg acttgagcgg tacatcgtat cccaagttct accaaaccct ccacaggcag      660

tgaacaacta taaggaagag cccgtaattg taaccccacc taccaaacaa tcactagtaa      720

aagtactaaa aactccaaaa tgtgcactaa aaatggatga ttttgagtgt gtaactccta      780

aattagaaca ctttggtatc tctgaatata ctatgtgttt aaatgaagat tacacaatgg      840

gacttaaaaa tgcgaggaat aataaaagtg aggaggccat agatacagaa tccaggctca      900

atgataatgt ttttgccact cccagcccca tcatccagca gttggaaaaa agtgatgccg      960

aatataccaa ctctcctttg gtacctacat tctgtactcc tggtttgaaa attccatcta     1020

caaagaacag catagctttg gtatccacaa attacccatt atcaaaaaca aatagttcat     1080

caaatgattt ggaagttgaa gatcgtactt cgttggtttt aaattcagac acatgctttg     1140

agaatttaac agatccctct tcacctacga tttcttctta tgagaatctg ctcagaacac     1200

ctacacctcc ggaagtaact aaaattccag aagatattct ccagctttta tcaaaataca     1260

actcaaacct agctactcca atagcaatta aagcagtgcc acccagtaaa aggttcctta     1320

aacatggaca gaacatccga gatgtcagca acaaagaaaa ctgaaattcc agtggatcta     1380

tccaacacag aaactgaaca aaatgagatg aaagccgagc tggaccgatt ttaacattca     1440

cattgccctg cctctgtccc cctttaaacg ttgacccatt ttaaagacaa acatgaacat     1500

taacatcata atatgctttt tatgaagttt caataaggtt taaccttagt cttgttgaca     1560

tgtagcccag tcattcactc tttaaggatt attagtgttt cattgatact aaattaccca     1620

gcttaatcaa cagaatggtt taagtagtac caggaagtag gacaagtaat ttcaaaaata     1680

taaaggtgtt tgctactcag atgaggccgc ccctgacctt ctggccagag agacattgct     1740

gccagccagc tctgccttcc catcatctcc tttcaggacc gtcccacacc ttttacttgc     1800

tcagtgctgt ctgaagatgc agttgctgtt tgcaaacaac aggaacacca gttaaactaa     1860

ttaggaaaag agggagattt ccaggcctgg gtaactatat actgtgacca ttggaggtag     1920

agacaggtct caacagttgg aaccaggaac tctgctgtca ggttgagagt tttgtttctc     1980

ttccagcttt tcactgtgtg ggggtctttt ctcttatgtc agctctttct atcacatggc     2040

agctgacctc tcacgctcca ctctgcagct tggacaccca gtagaccctg aatttcactc     2100

tctctaaaag gttctgaggg ctcatcctgg gccaggggcc ctcctgtgca ctgttagcta     2160

tggccacggg agcctccaga gctgcctggt agcttcaggt tgacctgctt atcaggccta     2220

cgatccttct gatttaagta cagctggaaa gtattatcta attaagttca tgatagtgct     2280

tttggagaac ttgtcaaatt acagccaatg agaaaataag gacctagcat actgtggaga     2340

accattaaaa atttgagaag aaacaacaag tattatgtca acttacttca aaggcgtagt     2400

tttgggaatt tgatgcagta aagattaccc tgttttatga ttgttccttg aaagtcaaat     2460

gggggacctg tccattgtgc tctattaatc ttgtcagaaa actgtcacca aaacaaaact     2520

tgagtttgtc cttgttctag gagttactgg gtagttgtaa gtattatttt tattaaatat     2580

aatgtaaaat aaaatgttaa gatacttagt tttgtttttc aaagtaaagc tgtagtcagc     2640

cttatgtatg ccattgactc tgaaatgtat accagccttt cactgtgtac cgtgtgtata     2700

taaatccaca gaaccggatg agctgcttag ggagggaata tattcaaagt gtaccaagga     2760

ccaaatcctg gagttctccc aactttagag gatggaaagg ggcagagtaa tctagcaaag     2820

gagactgagg ccagtgaagt aggaagaaag tatttcaagg agagtgatga ttctgtgaat     2880

attgctgaga attcaaataa aaagaggact gagaactga                            2919


<210> 845
<211> 3124
<212> DNA
<213> Homo sapiens

<400> 845
ggaagcgagt aagagaaagg ggaaggggag gtgggagagg cacctcaact ttgatgtccc       60

gagccttgag tggccactcg caagctggcc aagggcttca cacaatttgc caagatgaca      120

gaggggacca agaagaccag caaaaagttc aagttcttca agttcaaggg ctttgggagt      180

ctctccaacc tccctcggtc cttcactctg agacgatcct cagcttccat cagtaggcag      240

tcccatttgg agcctgacac ctttgaagcc acgcaggatg acatggtgac ggtgcccaag      300

agtcccccag cctatgcccg ctccagtgac atgtacagcc acatgggcac catgcctcgc      360

cccagcatca agaaagcaca gaactcacag gctgcccggc aggcccagga ggcgggtccc      420

aagcccaact tggtacccgg aggtgtaccc gaccccccag gcttggaggc agccaaagag      480

gtgatggtga aggccactgg ccctctagag gacaccccag caatggaacc caacccttca      540

gcagtggagg tagaccccat cagaaagcct gaggtcccca caggagacgt agaagaggag      600

agacctccca gggacgtgca ctcagaaagg gctgctggag agccagaggc tggcagcgac      660

tatgtgaagt tctccaagga gaagtacatc ctggactcat cgccagagaa actccacaag      720

gaattggagg aggagctcaa actcagcagc acggatctcc gcagccatgc ctggtaccat      780

ggccgcatcc cccgagaggt ctcggagacc ttggtacaac gcaacggcga cttcctcatc      840

cgggactcac tcaccagcct gggcgactat gtgctcacgt gccgctggcg caaccaggcc      900

ttgcacttca agatcaacaa ggtggtggtg aaggcaggcg agagctacac acacatccag      960

tacctgtttg agcaggagag ctttgaccac gtgcccgccc tcgtgcgcta tcatgtgggc     1020

agccgcaagg ctgtgtcaga gcagagtggt gccatcatct actgcccggt gaaccgcacc     1080

ttcccactgc gctacctcga ggccagctat ggcctgggac aggggagtag caagcctgct     1140

agccccgtca gcccctcagg ccccaagggc agccacatga agcggcgcag cgtcaccatg     1200

accgatgggc tcactgctga caaggtcacc cgcagcgatg gctgccccac cagtacgtcg     1260

ctgccccgcc ctcgggactc catccgcagc tgtgccctca gcatggacca gatcccagac     1320

ctgcactcac ccatgtcgcc catctccgag agccctagct cccctgccta cagcactgta     1380

acccgtgtcc atgccgcccc tgcagcccct tctgccacag cattgcctgc ctcccctgtc     1440

gcccgccgtt ccagtgagcc ccagctgtgt cccggaagtg ccccaaagac ccatggggag     1500

tcagacaagg gcccccacac cagcccctcc cacacccttg gcaaggcctc cccgtcacca     1560

tcactcagca gctacagtga cccggactct ggccactact gccagctcca gcctcccgtg     1620

cgtggcagcc gagagtgggc agcgactgag acctccagcc agcaggccag gagctatggg     1680

gagaggctaa aggaactgtc agaaaatggg gcccctgaag gggactgggg caagaccttc     1740

acagtcccca tcgtggaagt cacttcttcc ttcaacccgg ccaccttcca gtcactactg     1800

atccccaggg ataaccggcc actggaggtg ggccttctgc gcaaggtcaa ggagctgctg     1860

gcagaagtgg atgcccggac gctggcccgg catgtcacca aggtggactg cctggttgct     1920

aggatactgg gcgttaccaa ggagatgcag accctaatgg gagtccgctg gggcatggaa     1980

ctgctcaccc tcccccatgg ccggcagcta cgcctagacc tgctggaaag gttccacacc     2040

atgtccatca tgctggccgt ggacatcctg ggctgcaccg gctctgcgga ggagcgggca     2100

gcgctgctgc acaagaccat tcagctggcg gccgagctgc gggggactat gggcaacatg     2160

ttcagcttcg cggcggtcat gggtgccctg gacatggccc agatttctcg gctggagcag     2220

acatgggtga ccctgcggca gcgacacaca gagggtgcca tcctgtacga gaagaagctc     2280

aagccttttc tcaagagcct caacgagggc aaagaaggcc cgccgctgag caacaccacg     2340

tttcctcatg tgctgcccct catcaccctg ctggagtgtg actcggcccc accagagggc     2400

cctgagccct ggggcagcac ggagcacggc gtggaggtgg tgctggctca cctggaggcc     2460

gcccgcacag tggcacacca cggaggcctg taccacacca atgctgaagt caagctgcag     2520

gggttccagg cccggccgga gctcctggag gtgttcagca cggagttcca gatgcgcctt     2580

ctctggggca gtcagggtgc cagcagcagc caggcccggc gctatgagaa gttcgacaag     2640

gtcctcactg ccctgtccca caagctggaa cctgctgtcc gctccagcga gctgtgaccc     2700

cagggacatt tcccctctgc agctgcggac agcgtcaggg gcagaggggc acacaacttt     2760

ccccagagca ccccaaggac actgtgatca acccgagaat gttctgggtt caactcaagc     2820

atctcccttg cacctccagg gtcctgcgtg gactctgggt tccatcccac ctgctacatg     2880

ctcaccaggt ctccattgag gaagaacagg aacgccggtt cccccaccag cttttgctgc     2940

tccccttcct gctggggttc cctgttttcg agccatggga ggcaggctgc tcacgcctcc     3000

tcactctctg tctgtccctc accaacacca aggcctccat ctcactgtaa ataagtctct     3060

gttctgtaaa tagatgtaca gaagccatgt tatttctttc atataataaa cttttatgac     3120

tctt                                                                  3124


<210> 846
<211> 850
<212> DNA
<213> Homo sapiens

<400> 846
gcgcctcggc ccgggcctta ctctccaccg actgcgtcag gatgagctcc aggttttctt       60

tgggccgatg cttcgtgtcc tccaccagct tatagacgcg atgtcgccgg tgcaggcgcg      120

gcttccggcc ctccccggcc agcggtacct tccaccagcg ctccacgatg accgtgccct      180

ggcggccagg aaagcgacgc atcacttata aggaagagga ggacttgaca ctccagcccc      240

gtcctgcctc cagtgctcct gagtccctag taggcctcca ggagggcaaa agcaccgagc      300

agggtaacca cgaccagctt aaagaactgt attcggctgg gaacttgacg gtgctggcta      360

ctgaccccct gctccaccag gacccagtac agttagactt tcacttccgc cttacctccc      420

agacctctgc ccattggcac ggccttctct gtgaccgtcg actcttcttg gatatcccat      480

atcaggcctt ggatcaaggc aaccgggaaa gtttgactgc aaccctggag tacgtggaag      540

agaagacaaa tgtggactct gtgtttgtga acttccagaa tgatcggaac gacagaggtg      600

ccctgctgcg ggccttcagc tacatgggct ttgaggtggt cagaccagat caccctgccc      660

tccctccctt ggacaatgtc atctttatgg tgtatcccct tgaaagggat gttggccacc      720

tgcccagtga gcctccttga acatgcttat tccaacgctt tgaggggctg gaagccttga      780

cacatggaat caggggcccg ggatgtgatt caggacactt tccatcctag gaataaaggg      840

tagtgcaatc                                                             850


<210> 847
<211> 3763
<212> DNA
<213> Homo sapiens

<400> 847
acggtggtgg cgtggagacg tgggggcgct tccggcagcg gcggcggtgg tgaaggccga       60

tgctgtgggg gtgggcgtgg agagaattct tctgtgggtc ctctggtgtt gagtggtcgg      120

cttggtgtgg tgtgcggagg agctccaggc ccgtcggcgc ggagtggtct cacgtgtgaa      180

acatggctac agattggctg ggaagtattg tgtccatcaa ttgtggagat agcttgggtg      240

tctatcaggg aagagtgtca gctgtggatc aggtcagcca gaccatttct ctcacccggc      300

ctttccataa tggagtgaag tgtcttgttc cagaagtcac cttcagggca ggtgacatta      360

cggagttaaa aattctggag ataccaggac ctggagacaa ccaacatttt ggagaccttc      420

atcaaacaga attaggcccc tctggtgctg gctgccaagt gggcatcaat cagaatggca      480

caggcaagtt tgtcaagaag ccagcctctt ccagcagtgc ccctcagaat atccctaaga      540

ggacagatgt gaagagccag gatgttgccg tttccccgca gcagcaacag tgctcaaaga      600

gctatgtcga caggcacatg gaatccttga gtcagtccaa aagtttccgt cgtcggcaca      660

actcctggtc atctagtagc aggcacccaa atcaggcaac tcccaagaaa agtggtttaa      720

agaatggcca gatgaagaat aaagatgacg agtgcttcgg ggatgatatt gaggagatcc      780

cagacacaga ttttgatttt gaagggaacc tggctctttt tgacaaggca gctgtgtttg      840

aggagattga tacctatgaa aggagaagtg gtacccgttc ccggggcatc ccaaatgaaa      900

ggcccactcg gtaccgccat gatgagaaca tcttggagtc cgagcccatt gtctatcgac      960

ggatcatagt gccccacaac gtgagcaagg agttctgcac ggactctggc ctggttgtcc     1020

caagtatttc ctatgagctg cataaaaagc tgttgtccgt ggctgagaag catgggctga     1080

cccttgagcg gagactggag atgacaggtg tgtgtgccag tcagatggca ctgaccctcc     1140

tcggaggacc taacaggttg aatcccaaaa atgttcacca gaggcctaca gtggctctac     1200

tgtgtggacc tcatgtgaag ggggctcagg gtatcagctg tggaaggcac ctagccaacc     1260

atgatgtcca ggtcatcctt ttcctgccca attttgtcaa gatgttggaa tctatcacca     1320

atgagctgtc gctcttcagc aagacccaag gccaacaagt gtctagcctc aaagatctgc     1380

ccactagccc tgtggacctg gtcatcaact gcctggattg ccctgagaac gtcttcctgc     1440

gcgatcaacc ctggtacaag gcagctgtgg cctgggccaa ccagaaccgg gcaccagtac     1500

tcagcataga ccctcctgtg catgaagtcg aacagggcat tgatgccaaa tggtcactgg     1560

cactgggcct gcctctgcca ctgggggagc acgcaggccg tatctatttg tgcgacattg     1620

gcattcccca gcaggtcttc caggaggtgg gcatcaacta ccactcgccc tttggctgca     1680

agtttgttat cccactgcac tctgcttaga gggttcctgc gcaggcagga ctctgctgtc     1740

ccctgctgct cctgataaca aacgccttaa ggatatgaag cttcatggac cttgttaaag     1800

ttttttctct tttgggtttg tttcttctgt gagagaacag aacttactta aaactgacct     1860

gtcacttgct cttagccagg gaagtctttc ccactgggtt ccgggctggg tggcaggctg     1920

agcgtgcagc aactccaggc atctctaccc tcagccccct gcacggccag gtgggccttt     1980

gtttacagcc gtaggcagct ctcaagactg tgtttcaggt ttacagccac tgggcctggg     2040

cacacacatt gaagagtggg ccaggtcctg tctgggggcc tgtacctgct ctatttcaga     2100

gcttgtggct ttgtgtctcc cctgctttcc ccacgcagac agcccttcct ctgtagaacc     2160

agctgcacgg cagctgtcca ccagagggca gacctgcact ctccattcat gtccagggct     2220

gtgacagacc aggccttccc ctagccccac aagttgattt ggggggtttt gacccttact     2280

cctgagctga tccaagtttt atgctgattt ttccaaggat ctctccctcc ttttccctcc     2340

atcactcaga ggtagggaag ggggcggcat taggatggtg ttactgtatt gggattttat     2400

gttgttctgt cgtcttcagc acaggtagta taaggttata ttactgtaga accacagtgc     2460

ccatcttgcc agcagtgccc gcccccaccc tcaaagctga gcaggttgag cctttgccta     2520

gtctggggcc agacccctca gatggggata tccctggggg agcctggtgc tgaaccagaa     2580

gaggcttcct ggtgcttctg tcctaggcca ccactcctcc agccctttgc ccgcacatac     2640

atgccccacc tactctttca tcccctctgc ccttcccctg aaacggtcct ttgcagctgt     2700

catcccagag caggcagatg ggctcccgtg cttgagctcc accccagctc ttacatcatc     2760

tgggctttga accttttaca tttgtccagt ctagatgagt aggcttgggg ccagcaccct     2820

gtctcaaaga tggcaaaatg aggctagttc tggatgagct agctggtgtg ggttccaacc     2880

ataggaacac actgatgctc aaatcctaag gtgccaagct ctaggccctg gaggctggta     2940

gaacaggatc tatgcctgga atcctggcag ggattcctgt caaggacttg tgtttaagcc     3000

tgcttcaggg cttcaggctg cttctgctct gtgtctgccc aggctggctg agcgggtgga     3060

tgggtggaca gaagggctca ccaaggattg tggacatagg gtaggccctg gtaccacggg     3120

tttcaggctg ttatcacttc ccttgtagga acatagccag aagcagatga gccagggtag     3180

agggctggcc cctcctctca tcttcccttc agtcttaaat tgtctccagc gatgggaaga     3240

ggccagggac tgtaaccctt gtgctgtgta ttctctgagc ctctgctcac tctcagggcc     3300

aagcagctcc caagccgggg ccctctcttg gccaaaatct gaggagcagt ctaggttaca     3360

ggctttttgg taggtaggtt ctggctgcct gttaatgcag ttaggccccc tgattaggta     3420

cagtgagaaa caagctagaa caaccctggc ccagaagact gtccactcca gcaagatcca     3480

gggatgatag ccttgcaggg ccactgggag tttgtgccca agcttctccc tcttctctcc     3540

ccagggggca ctgggactgg tccctgccct catccttagc ctgggccttc cccagaggta     3600

ttaaagagaa gtatgattcc tctgtcttca gttcttttca ggggcatcct gcccatagta     3660

cccagttccc aaggggcccc cagtcacgtg gtgaagccta gcactcatgc agctcttagg     3720

gaaccaaaaa ccagcactga aataaagctg aatgactgac tga                       3763


<210> 848
<211> 1364
<212> DNA
<213> Homo sapiens

<400> 848
ggccaacagg gggcgccgtc gtgggggcgg cactgggagc gccttccgga gagacgcagt       60

cggctgccac cccgggatgg gtcgctggtg ccagaccgtc gcgcgcgggc agcgcccccg      120

gacgtctgcc ccctcccgcg ccggtgccct gctgctgctg cttctgttgc tgaggtctgc      180

aggttgctgg ggcgcagggg aagccccggg ggcgctgtcc actgctgatc ccgccgacca      240

gagcgtccag tgtgtcccca aggccacctg tccttccagc cggcctcgcc ttctctggca      300

gaccccgacc acccagacac tgccctcgac caccatggag acccaattcc cagtttctga      360

aggcaaagtc gacccatacc gctcctgtgg cttttcctac gagcaggacc ccaccctcag      420

ggacccagaa gccgtggctc ggcggtggcc ctggatggtc agcgtgcggg ccaatggcac      480

acacatctgt gccggcacca tcattgcctc ccagtgggtg ctgactgtgg cccactgcct      540

gatctggcgt gatgttatct actcagtgag ggtggggagt ccgtggattg accagatgac      600

gcagaccgcc tccgatgtcc cggtgctcca ggtcatcatg catagcaggt accgggccca      660

gcggttctgg tcctgggtgg gccaggccaa cgacatcggc ctcctcaagc tcaagcagga      720

actcaagtac agcaattacg tgcggcccat ctgcctgcct ggcacggact atgtgttgaa      780

ggaccattcc cgctgcactg tgacgggctg gggactttcc aaggctgacg gcatgtggcc      840

tcagttccgg accattcagg agaaggaagt catcatcctg aacaacaaag agtgtgacaa      900

tttctaccac aacttcacca aaatccccac tctggttcag atcatcaagt cccagatgat      960

gtgtgcggag gacacccaca gggagaagtt ctgctatgag ctaactggag agcccttggt     1020

ctgctccatg gagggcacgt ggtacctggt gggattggtg agctggggtg caggctgcca     1080

gaagagcgag gccccaccca tctacctaca ggtctcctcc taccaacact ggatctggga     1140

ctgcctcaac gggcaggccc tggccctgcc agccccatcc aggaccctgc tcctggcact     1200

cccactgccc ctcagcctcc ttgctgccct ctgactctgt gtgccctccc tcacttgtgg     1260

gccccccttg cctccgtgcc caggttgctg tgggtgcagc tgtcacagcc ctgagagtca     1320

gggtggagat gaggtgctca attaaacatt actgttttcc atgc                      1364


<210> 849
<211> 2881
<212> DNA
<213> Homo sapiens

<400> 849
cgttgtcggg ttcgactgga ggggcggggg agtcacctgc gagcggctgc gctggcggcc       60

agcccgccca ccgcgtctgg atcgcgccgg ctgcgcgggg ctgcggacag cacacaccct      120

ggaaggcccc ggcggggaac gggcagagtc cgcgccctgc gtccgcgacc aggaggatcg      180

gaccttcgcc ttcgctgtcg ccgccgccgc cgcccgcggc cgtcggggct attagtgaaa      240

gatggtggat cgcttggcaa acagtgaagc aaatactaga cgtataagta tagtggaaaa      300

ctgttttgga gcagctggtc aacctttaac tatacctgga cgagttctta ttggagaagg      360

agtattgact aagttgtgca ggaaaaagcc caaagcaagg cagtttttct tgtttaatga      420

tattcttgta tatggcaata ttgtcatcca gaagaaaaaa tataacaaac aacatattat      480

tcccctggaa aatgtcacta ttgattccat caaagatgag ggagacttaa ggaatggatg      540

gctaatcaag acaccaacta aatcttttgc agtttatgct gccactgcta cggagaaatc      600

agaatggatg aatcatataa ataaatgtgt tactgattta ctctccaaaa gtgggaagac      660

acccagtaat gaacatgctg ctgtctgggt tcctgactct gaggcaactg tatgtatgcg      720

ttgtcagaaa gcaaaattca cacctgttaa tcgtcgccac cattgccgca aatgtggttt      780

tgttgtctgt gggccctgct ctgaaaagag atttcttctt cccagccagt cctctaagcc      840

tgtgcggatt tgtgacttct gctatgacct gctttctgct ggggacatgg ccacatgcca      900

gcctgctaga tcagactctt acagccagtc attgaagtct cctttaaatg atatgtctga      960

tgatgatgac gatgatgata gcagtgacta aggacacatt tgggagtatt taatcaggtg     1020

tggctatctg agaaatcaac tttgggggaa atgtaagatt ctgagctctc tctctgtttt     1080

gttctagcca tgaatttgcc tgagaaactt gtaacctatg tgcctcaata tattccatag     1140

aaagtaggtc cccctgcctt ctcccactcc tcacactctt ctacagggat aggcttttgc     1200

aaatatatca gataaatttt ttgtttcttg tttattttta ggttattttc ttggaaggtt     1260

gggaaaagat gtttgtttta acaggtcatg tactacgttg ttgttttcat ttctgttata     1320

agtaaaacta aaagcacaga atggtgggaa aggggctata atgtggttca ttaataatgt     1380

tagcagcttt tttctaacca tcctgtctaa tggttaagac accagtaaca aaaacacatg     1440

atttggaaat actttggctt tttcatatac ctagtggtgc cttatcataa tagcactgtt     1500

acatgaaata agcccctacc ttcttacttt ctggtttgtt gaaaaaatac actggtgctc     1560

tttgaagtga taaaatgagt gtttatgaat gggtgtaatt aggaaatact tctcatctga     1620

cagctacaaa taactaagtt tggaggtatt ttcactctat atgaataaat atttttccat     1680

aaaatagttg tgattatatt tttgttttat ataggtccca aattataatt gtcaaatata     1740

tattttaaat taataaaagt tgtcattctt aggaatttgg tttgaaattt atcagttata     1800

cagaattgtc atactgcatt agcttctacc tttagtaaga catatttttt aggtataaat     1860

tcttatgctt taacattatt tctggattga aaatcttata aaacccttga aaataaacag     1920

tctctttttt acaaagcctg tgttagagca cagatttacc taggcttgaa gatttggaag     1980

aaataatatg taagaatggc ctcaaggcag accactttaa gtttggctag acttcatatc     2040

gtggaagtat tgtctatttc agtgtgaaac tatcttgaat ttgcaaatat agtgttatat     2100

tttataaagt tttgtaaaat cccaaacaat atttctattt ttgtaaaaca attgtatgta     2160

taatctgtat ttgaaatcat tttgcaatct atggaaatag agtagcaatt gctatttcta     2220

aattgtgaac tttaagtcaa tctagattta ttttgagaag taattgttca ctctttactt     2280

ttgaggcagc cattaggttg aaagtatata tttatcatat aaaacttgat gcgttttgca     2340

ctactctttc catttatatg ctgcaaacaa ctacagtctt tgaaatatgg aaaatcagca     2400

gtctaaagtt tgttttaaat tctaaattta aaaaatcttc aaatctgaat ataccgcaaa     2460

tgtcatgaga agtttgattc agtaacttgt gatggaggat tctttggtat cttactgttt     2520

ggttaaggca ctaattttac ttacctatta gattttgaaa gtatctgaga tatacaaatc     2580

tccctgtagg aaatgtgaaa gaaaagcaca acaaaactag ggttttttgt tcatttgctt     2640

gcttttatga ttttttttgg tttgttttaa tatcaggtgg atttttgttt ctaagcaata     2700

tatacataaa atcaaccaac atatctgaaa aggatcatga aacctgagaa atgctaatgg     2760

agatttgctg gtacatagga atctagcaaa ttcaggaacc aaggggaaat gttgtgagat     2820

aacatttaca ttgtcaacct ttattgactt tgtttttaca ataaaaaata ttttacaact     2880

t                                                                     2881


<210> 850
<211> 4458
<212> DNA
<213> Homo sapiens

<400> 850
caggcggcgg cggcgcagtt gcgagtgcag gctccttgcc agaggcctcc actcactcca       60

gacccctata gcccgtcgct gtcagctgtc aacaaaggat gcgaatgctg gccgcttcct      120

gtgggcttcg tgtcacccag aggtgagccc aggccaggat gggggactcc agggaccttt      180

gccctcacct tgactccata ggagaggtga ccaaagagga cttgctgctc aaatctaagg      240

gaacctgtca gtcgtgtggg gtcaccggac caaacctatg ggcctgtctg caggttgcct      300

gcccctatgt tggctgcgga gaatcctttg ctgaccacag caccattcat gcacaggcaa      360

aaaagcacaa cttgaccgtg aacctgacca cgttccgact gtggtgttac gcctgtgaga      420

aggaggtatt cctggagcag cggctggcag cccctctgct gggctcctct tccaagttct      480

ctgaacagga ctccccgcca ccctcccacc ctctgaaagc tgttcctatt gctgtggctg      540

atgaaggaga gtctgagtca gaggacgatg acctgaaacc tcgaggcctc acgggcatga      600

agaacctcgg gaactcctgc tacatgaacg ctgccctgca ggccctgtcc aattgcccgc      660

cgctgactca gttcttcttg gagtgtggcg gcctggtgcg cacagataag aagccagccc      720

tgtgcaagag ctaccagaag ctggtctctg aggtctggca taagaaacgg ccaagctacg      780

tggtccccac cagtctgtct catgggatca agttggtcaa cccaatgttc cgaggctatg      840

cccagcagga cacccaagag ttccttcgct gcctgatgga ccagctgcac gaggagctca      900

aggagccggt ggtggccacg gtggcgctga cggaggctcg ggactcagat tcgagtgaca      960

cggatgagaa acgggagggt gaccggagcc catcagaaga tgagttcttg tcctgtgact     1020

cgagcagtga ccggggtgag ggtgacgggc aggggcgtgg cgggggcagc tcgcaggccg     1080

agacggagct gctgatccca gatgaggcgg gccgagccat ctctgagaag gagcggatga     1140

aggaccgcaa gttctcctgg ggccagcagc gtacaaactc ggagcaagtg gacgaggacg     1200

ctgatgtgga cactgccatg gctgcccttg acgaccagcc cgcggaggcc cagcccccgt     1260

caccacggtc ctccagcccc tgccggacgc cagagccgga caatgatgct cacctacgca     1320

gctcctctcg cccctgcagc cccgtccacc accacgaggg ccatgccaag ctgtctagca     1380

gcccccctcg tgcaagcccc gtgaggatgg caccgtcgta cgtgctcaag aaagcccagg     1440

tattgagtgc tggcagccgg aggcggaagg agcagcgcta ccgcagcgtc atctcagaca     1500

tctttgacgg ctccattctc agccttgtgc agtgtctcac ctgtgaccgg gtatccacca     1560

cagtggaaac gttccaggac ttatcactgc ccattcctgg aaaggaggac ctggccaagc     1620

tccattcagc catctaccag aatgtgccgg ccaagccagg cgcctgtggg gacagctatg     1680

ccgcccaggg ctggctggcc ttcattgtgg agtacatccg acggtttgtg gtatcctgta     1740

cccccagctg gttttggggg cctgtcgtca ccctggaaga ctgccttgct gccttctttg     1800

ccgctgatga gttaaagggt gacaacatgt acagctgtga gcggtgtaag aagctgcgga     1860

acggagtgaa gtactgcaaa gtcctgcggt tgcccgagat cctgtgcatt cacctaaagc     1920

gctttcggca cgaggtgatg tactcattca agatcaacag ccacgtctcc ttccccctcg     1980

aggggctcga cctgcgcccc ttccttgcca aggagtgcac atcccagatc accacctacg     2040

acctcctctc ggtcatctgc caccacggca cggcaggcag tgggcactac atcgcctact     2100

gccagaacgt gatcaatggg cagtggtacg agtttgatga ccagtacgtc acagaagtcc     2160

acgagacggt ggtgcagaac gccgagggct acgtactctt ctacaggaag agcagcgagg     2220

aggccatgcg ggagcgacag caggtggtgt ccctggccgc catgcgggag cccagcctgc     2280

tgcggttcta cgtgtcccgc gagtggctca acaagttcaa caccttcgcg gagccaggcc     2340

ccatcaccaa ccagaccttc ctctgctccc acggaggcat cccgccccac aaataccact     2400

acatcgacga cctggtggtc atcctgcccc agaacgtctg ggagcacctg tacaacagat     2460

tcgggggtgg ccccgccgtg aaccacctgt acgtgtgctc catctgccag gtggagatcg     2520

aggcactggc caagcgcagg aggatcgaga tcgacacctt catcaagttg aacaaggcct     2580

tccaggccga ggagtcgccg ggcgtcatct actgcatcag catgcagtgg ttccgggagt     2640

gggaggcgtt cgtcaagggg aaggacaacg agccccccgg gcccattgac aacagcagga     2700

ttgcacaggt caaaggaagc ggccatgtcc agctgaagca gggagctgac tacgggcaga     2760

tttcggagga gacctggacc tacctgaaca gcctgtatgg aggtggcccc gagattgcca     2820

tccgccagag tgtggcgcag ccgctgggcc cagagaacct gcacggggag cagaagatcg     2880

aagccgagac gcgggccgtg tgatctgctg ggctagtctg taagtcgccc cggctggtcc     2940

ctccatggca ctctgggtcc tctcctcact ctccagagac cctcacatgt ccttttgaac     3000

atccaaagag caggtccctg aaagcacctt cctggaggat gtgggagggc cctggacatg     3060

gcccggcccc actgctgagt gcccgtgtcc ccacagcccc atgtgcccca ccccgcggaa     3120

ggcgtgtttg tgcccagaag agaggccggg ctgctgcaga accccgccgt gtaaagaggc     3180

agaaaagttg gtttggtttg cagtaacgct gcaactagaa aatatatgca cttcaggctt     3240

gttgaaacga ccaagactct gtgacgttaa tttgggtctt tgtcctggca gtgcctctgc     3300

cagtcactgt catcgttgtg tcccccacaa ctgtcctctt gctagctcgg cccagctttg     3360

tccctggagc ccgatgctac ccctgtcaga cagaggctgc ggcctgggcc agagtcaggg     3420

agtagctgct gcttcacggc gtctccactg tgcgattggc ccggagcccc gaagactcgg     3480

agggagctgc tcagggccgg tgagcgcagc cagaagccct ggccagtgag gagctcacag     3540

gtcctccctg gtggtcccgc cgcacctctg catctcctgg gcgtcaccag gaaggctctg     3600

aagtcccggg ctgctctcag cacttctcct gcagactgaa gactctggac tcattgctga     3660

ttggaacacc aggaggaggt tggatttctg ccagtggggg atgtttctgg aggcagctgg     3720

tcccccacac cgcgtcctgc tgagcctgcc ccctggattg gctgtaattt gcctcgaagt     3780

tcagcagttc atcttcatgg gaaatttgct gagcccccac cagggaaccg gatgatgaaa     3840

cagggatacc tcacagcttg gccatttgag gcaaaggcag cttcccgagc tgatgctaaa     3900

gaagacagac tttcccttcc tcccagcagc agcagtgcag agcccacctg gagggatgtg     3960

ggggctgtgc agggtgcagc gctcaggtgg atcctgggaa gcagcctctg gatgctgagt     4020

ggagggagcc actgagcaca gcaaggcacc aaagcccctg gagaaaccgc cagggcgagg     4080

tgcgaccatc atcaggatca aagcagacgg ggcgtgggtg gggaaggggc tctgggacca     4140

gaccccccac actactgcgt ctttgtttct atcagtcttt gtagaagcag gtggtggtgg     4200

aaattccagc aggtgggtcc cgcagaggcc ctgaggcctc acttttcgga tcttctgtcc     4260

cagatcctgc tccctccctg ctgagcctgg ggttcccctg gcattggccc cagccttctg     4320

aaagccggcg ctgcagccag aggccgcacg ctgcactgtc gcgacgcaga gaggcttctg     4380

tgcaggctgg gatcgggccc catgtctgtg ctgtctagtt tgtgttcaaa atgtcagaat     4440

aaacacagaa taaatgtt                                                   4458


<210> 851
<211> 1755
<212> DNA
<213> Homo sapiens

<400> 851
gcggccgccg ccccaccgta ggtccgtagc aggtggtcga agtcgggcct ccccgcgggc       60

gtcacccagc gccgccggct gccccagccc tgcgtgaagg cgctggaaaa cacgcagggc      120

aggttgggca gcaagaagcc ccgcacaaag tcggcgtagg agaaggcgcc cggctccgag      180

acgaaggcta cccggcccgg agcctggccg acgccgggga catcgacccc caggcctcgg      240

aagtggctgt cggcgagggc gcgcgtctcg cggtccatcc agctcagcac gggtcgaagg      300

accctcctcc tcacttccgc cggagcggaa acggtgagga ccagcctcgg aaccagaaga      360

cgcagggcgc cgcgtttctg ccccgccagc gcctggggct ccgggcctgc acgcatgcgc      420

gcggctcgcc gcggtcttca ctgcgcaggc gccgagcggc cgaggcgccg cggtcggctc      480

tgggactcgt ctggcgtccc tcagaggcag aagaggcctg gaccttggcg cacacagacc      540

caggaacaga tgagcaggga tgtctgcatc cacacctggc cgtgcaccta ctacctggag      600

cccaagaggc gatgggttac tggacagctg tccttaacat cgctgtcgct caggttcatg      660

actgacagca ctggagagat tctggtcagc ttccccctct ccagcatagt tgagatcaag      720

aaggaggctt cacattttat cttcagctcc atcaccatcc tggagaaggg ccatgccaag      780

cactggttca gctccctgcg gccaagtcga aatgtggtct tcagcatcat cgagcatttc      840

tggagggagc tgctgctgtc tcagcctgga gccgtggcag acgcatctgt cccaaggacc      900

cggggcgagg agctgacggg actcatggct ggatcccaga aacgcctgga ggacacggcg      960

agggtcctgc accaccaggg ccagcagctg gacagcgtca tgagaggcct ggacaagatg     1020

gagtcagacc tggaggtggc ggacagattg ctgacagaac tggaatctcc tgcttggtgg     1080

ccctttagct ccaagctttg gaagacacca ccggaaacaa agcccaggga agatgtctcc     1140

atgaccagtt gtgaaccctt tgggaaagaa gggatactga taaaaattcc tgctgttatt     1200

tcccacagaa cagagtctca cgttaaacca gggaggctca ccgtccttgt gtctgggttg     1260

gaaatacatg actccagttc tttgctcatg cacaggtttg aaagagaaga cgtggacgac     1320

atcaaggtcc actcacctta cgaaattagc atccgccagc ggtttattgg aaagccagac     1380

atggcctatc gtttgatatc tgccaagatg ccagaggtta tccccatttt agaagtgcag     1440

ttcagcaaga agatggagct gttagaagat gcattggtgc tcagaagcgc aagaacctct     1500

tcccccgcag agaagagctg ctcagtctgg catgcagcat ctgggctgat gggccgtacc     1560

ctgcaccgtg agccacccgc aggagaccag gagggcacag cactgcacct gcagacaagc     1620

ctgccagccc tttctgaggc agatacccag gaactaaccc agggcttccg gcctatgtcg     1680

ctgtcaaccc agacagtgtt ggtgatgctt tgctccgagt ctgcaggagc tttgtggaga     1740

cagagacttt cctag                                                      1755


<210> 852
<211> 2103
<212> DNA
<213> Homo sapiens

<400> 852
ctgttcttgt gaggctgagg gtctggggtc gcctgcgagg ccgctggcca ggcctgagcc       60

tctgccacca tggccattgt gcagactctg ccagtgccac tggagcctgc tcctgaagct      120

gccactgccc cacaagctcc agtcatgggt agtgtgagca gccttatctc aggccggccc      180

tgtcccgggg ggccagctcc tccccgccac cacggccctc ctgggcccac cttcttccgc      240

cagcaggatg gcctgctacg gggtggctat gaggcacagg agccgctgtg cccagctgtg      300

ccccctagga aggctgtccc tgtcaccagc ttcacctaca tcaatgagga cttccggaca      360

gagtcacccc ccagcccaag cagtgatgtt gaggatgccc gagagcagcg ggcacacaat      420

gcccacctcc gcggcccacc accaaagctc atccctgtct ctggaaagct ggagaagaac      480

atggagaaga tcctgatccg cccaacagcc ttcaagccag tgctgcccaa acctcgaggg      540

gctccgtccc tgcctagctt catgggtcct cgggccaccg ggctgtctgg gagccagggc      600

agcctgacgc agctgtttgg gggccctgcc tcctcctcct cctcttcctc ctcctcttca      660

gctgctgaca aacccctggc atttagtggc tgggccagtg gctgcccatc agggacgcta      720

tccgactctg gccgaaactc actgtccagc ctgcccacct acagcaccgg aggtgccgag      780

ccaaccacca gctccccagg cgggcacctg ccttcccatg gctctgggcg aggggcactg      840

cctgggccag cccgaggggt ccctactggg ccctcccact cagacagtgg ccggtcctcc      900

tccagcaaga gcacaggctc cctagggggc cgtgtggctg gggggctttt gggcagtggt      960

actcgggcct cccctgacag cagctcctgt ggggagcgct caccaccacc cccgcctcca     1020

cctccttcgg atgaggccct gctgcactgt gtcctggaag gaaagctccg agaccgggag     1080

gcagagcttc agcagctgcg ggacagtctg gacgagaatg aggctaccat gtgccaggca     1140

tacgaggagc ggcagcggca ctggcagcga gagcgtgagg ccctgcgaga ggactgtgcg     1200

gcccaggcac agcgggcaca gcgggcccaa cagctgctgc agctgcaggt gttccagctg     1260

cagcaggaga agcggcaatt gcaggacgac ttcgcacagc tgctgcagga gcgcgaacag     1320

ctggagcggc gctgcgccac cttggagcgg gagcagcggg agctcgggcc gaggcttgag     1380

gagaccaagt gggaggtgtg ccagaaatca ggcgagatct ccctgctgaa gcagcagctg     1440

aaagagtctc aggcagagct ggtgcagaag ggcagcgagc tggtggctct gcgggtggcg     1500

ctgcgggagg cccgtgctac gctgcgggtc agtgagggcc gtgcgcgggg tctacaggag     1560

gccgcccgag ctcgggagct ggagctggaa gcctgttccc aggagctgca gcgacaccgc     1620

caggaagctg agcagctgcg ggagaaagct gggcagttgg atgctgaggc ggccggactc     1680

cgggagcccc ctgtgccacc tgccaccgct gacccattcc tcctggcaga gagtgatgag     1740

gccagtgcca ctgccaaccc tgttcacagg cgcttccagc ccactccagc caggggagca     1800

gggaagaaga aggggctccc tcctcttcac attccccccg accccaaagc cagagaaagc     1860

cagatggcac cagctgctcc ggatgtgcct gcccacattg ggggacaggg ccgggcctgg     1920

gctcggttcc caggtttgag ctctgcagcc tctctcctgg agtgaggggg ctgaagtcag     1980

accaaaggaa gaactcagaa atgtcttgtt tatttgtgtt tgtgaccaag cagcctctcc     2040

cttcacccag gtttatggcc tcgttttcac ttgtatattt ttcacactgt aaatttcttg     2100

tac                                                                   2103


<210> 853
<211> 5763
<212> DNA
<213> Homo sapiens

<400> 853
aaaagggcgg tggggcgggg ggcggggcag ggagagggag agaaatccag cagacatcta       60

gctctgcctt tctttcccag ccacagccag ggtagggctg ataaggcgct gatgcgttga      120

tggcagcctt gcagagctag acctgcactt aacttgcagc tgcctcccga gcctccaaga      180

tgtccacgcc ctgggtgaca ggcggcaggg cgctgccccg tgctcccccg gctctgctcg      240

acagcagcac gcagtgagag cctcgccgcc gccgaggagc aactcatgta acggcacagc      300

caacaagatg aacggagctt tggatcactc agaccaacca gacccagatg ccattaagat      360

gtttgtcgga cagatccccc ggtcatggtc ggaaaaggag ctgaaagaac tttttgagcc      420

ttacggagcc gtctaccaga tcaacgtcct ccgggaccgg agtcagaacc ctccgcagag      480

taaaggttgt tgtttcgtaa cattttatac aagaaaagct gcacttgagg cccagaatgc      540

actgcacaat attaaaactt tacctgggat gcatcatccc attcagatga aacctgcaga      600

tagtgaaaag tccaacgctg tggaagacag aaaattgttc ataggaatgg tatcgaagaa      660

atgtaatgag aacgacatca gggtgatgtt ctctccattt ggccagatag aagaatgccg      720

gatcctccgg ggacctgatg ggctgagtcg aggctgtgcg tttgtcacat tttctacaag      780

ggcaatggca cagaatgcaa tcaaagccat gcatcagtct cagaccatgg agggctgctc      840

ttcacctatc gtggtgaagt ttgctgacac tcagaaggac aaagagcaaa ggcgcctcca      900

gcagcagctc gctcagcaga tgcagcagct caacactgcc acctggggga acctgacagg      960

gctgggcgga ctgaccccac agtatctggc gctcctgcag caggccacct cctccagcaa     1020

cctgggtgcg ttcagcggca ttcaacaaat ggcaggcatg aatgctttac agttgcagaa     1080

cctggcgacg ctggctgctg ctgcagctgc ggcccagacc tcagccacca gcaccaatgc     1140

aaaccctctc tctaccacga gcagcgccct gggagccctc acgagtcccg tggctgcttc     1200

aacccccaac tccactgctg gtgcagccat gaactccttg acctctctcg ggactctgca     1260

aggactggct ggagccactg ttggactgaa taatattaat gcactagcag ttgctcaaat     1320

gctctcaggt atggcggctc tgaatggagg acttggcgcc acaggcttga cgaatggcac     1380

ggctggcacc atggacgccc tcacccaggc ctactcagga attcaacagt acgcagccgc     1440

cgcgctgccc actctgtaca gccagagcct gctgcagcag cagagcgctg caggcagcca     1500

gaaggaaggt ccagaggggg caaacctctt tatttaccac cttccacagg aatttggaga     1560

ccaggacatt ctgcagatgt tcatgccttt tggaaatgtt atctctgcta aagtcttcat     1620

tgacaaacag accaatctga gcaagtgctt tggttttgtt agctacgaca atccagtctc     1680

tgcacaagct gctatccaag ctatgaatgg ctttcagatc ggcatgaaac gcttgaaggt     1740

gcagctgaag cgttccaaaa acgacagcaa accttactga tcctaacccc agaggctccc     1800

tgctctcatt ttagctttct taggacatct tcatgcccgt tagttcatcg tttgcctagc     1860

atgtccctgt ggcgtctcaa aaaaaagttt catcgtcccg tcattgtttc tgatgtcttt     1920

ctgacctcac atcatatttg gttctcctac tgacctttga tctagtttga cctttgaaat     1980

ttgcatgtga cctcatctag ctatgaattc tgggaagtca atgtgaaaaa cattgctgca     2040

ttcatgcaag actgaaattt attattagac aaattcatta tagaaaaaac ctgtggcaaa     2100

aacgtttctt tcttattttt tttcttttcc taaaacagac ttgaaagtat tatacaggga     2160

ttggcattct tcccggtcac tggtaacaat agcaatatgt gtccagggac acagaatgtt     2220

ggtttctaac agactacttc caaaaacagt ttgagaaaaa aactgtctga ttttaagtct     2280

ctagaggtct gtaatagttt ttacattttt caggcagtgt aaagtttttt gataaggcca     2340

ttttaggtgg ctcactttct cattaagata tatatataga accacttttt gtagattagt     2400

ataagaaaaa tatttaccct gttttggggc aaatgctacc tatttgtgtc accttttgct     2460

gaactcacag ttagacaatc catggtttaa tgcacatgaa attacctata ttttatactg     2520

tttcaatgta caggagaaag gttactgtaa actgtgttat gttggtgctt ctgtgaatta     2580

agttgtggtt tcatcatgag tcttaatgtt ctttgttgat aagacaagtt tagaattggt     2640

ttacttaata caaaaaaaaa aaaaagaatt tcaaaaaaaa aagttgtttg cttaaaaaaa     2700

atttcatgtg agggaaaaaa aaaaaaccta ttccagaata agttttgtgt tggcttgtga     2760

agcattgatg tcattttttt taattgtgga ctatttagat gtgtttgtgt tcagcaaaat     2820

gtgatgtttt tttcttttaa agaaaaaaag tgaaaatata tagtgccaaa ttccaaaggt     2880

acttccttcc tagagcttca gtgtgtttct tgtgagaagt aatttgataa catgggtatt     2940

ttattatgtg ttttgtataa atccctaata tttaaaaaaa aaaacaaaac aaaaaaaggt     3000

tacaaagttt gttaacttgc tatcctgtgg tcttgttgcc tgaaattgtt attgtttgtt     3060

atttctctct gatgtttttt gtaagacatt gtataagtgc ccatgtccca cttttttaac     3120

cactccgcac atcagtgctg tgaaggcaac ctcaccatgt attttcttca taatctatgg     3180

aaacctctaa ggtgagaaag ttttgaactt ttaacccttt ctacccagag ctatctggaa     3240

tgttgatgac tttttatact gtcatgattt gagtttgttt tggggtgttt ccaatttgga     3300

tttttttccc tgcatctatc ctctaagttg tttcggtttg actactttgt tctttggtta     3360

agatccaaaa gaaaacagaa aacaattcca cgaggccaat ctaaagggaa aaaatcctac     3420

actactttta ctacttttga ttatttctca tttttgggaa aagaattcct aatgtgctac     3480

tagaattcct tcttcagttt taacgagtaa ttggataaac cctgagggaa aacggaggta     3540

gattcagcac ctaacaatcc tgtatgcttt tgagatcacg tttagtgcta tgtcctagtc     3600

tagaatattt tcatatacct tgcagtaaaa cgactttgtg gcaggacagt ctcttgaggg     3660

gttttgtttc tgtttcctaa atactcctaa ataatatttc taatcagcca ttatgctggg     3720

gcatctctga tcccagtagg tacctctgaa tataccaggt gtctggagtt agaagcccat     3780

agccctttcc cagccttttt ggttttttta attgaacaca tttcatctaa gtaaagctca     3840

gttctttatc acaatttact gaccaaatac ctagcaccag ttcctgctgc cactttttaa     3900

agtgccatat gactttctac gaacaggtac cttgctgtct tgacaaatcc taatgtcacg     3960

cctacagccc caacacaagc tccagtcttc ctcttcggca tgccctggaa gcttcttcca     4020

gtcttcctct tcggcatgcc ctggaagctt cttggcctca gctccccttc cccgctcagc     4080

accctgttag gatcagtgtg tgtggatggg atagccctgg gatggaaagg actagcctct     4140

actgatgcaa aaaaacaaaa agcaacacaa acgtttcctt cttatagcac atgcacttcc     4200

ttacaatgac atgatttgta ttatcctcac atgtgtttac tactgctggg gccttccttc     4260

atcctctgag ggctattttg tactttctgc agcaatcagc ttaataacaa cacttattgc     4320

acctgtctct ctctgagaac acggtgtgtc tcgacacgta ccacgtacgt ggaaacacaa     4380

gagcccacca cttgaatttc taagaccatt tcattctgaa acttcttatc aattacctaa     4440

atctcaacga aaaacaattt actgaagccg actcccctcc ccatctccct ctcaacctca     4500

acccacctgc atgcatctcc cccagaggaa acactgaggg taggggacag gaggctcagg     4560

acgcgccctc tgaatcgagt gtttcttctt cacaagtcac caagagagga catgaggggg     4620

aaagtccttt ttgcccttct ccaaaaaata accttccaca gagacaaact gtccttctat     4680

ccacttttat cttttaataa atatcaaaag gaaaaagctg caagggtgca aagggcctgt     4740

gccagaagaa aacacacaca gggaaaccgc tttttttaat caattgtaga gaatagtcat     4800

ttttaatcta aattagagaa ttgtgataca atggcagtcc tcaaaggcgt aacgagttca     4860

tctttctttc accatagggg ttatagttgg cttgtgctac tctggaatca ttttactgtt     4920

tgtttttatt atcttaagtg ctaattaaaa aaaaaataaa attttaaaaa aacctgtagt     4980

ttcattacct ttttgaataa tgtcatacaa aaaatgtatt tgtttttttg tgctgtgaga     5040

attgatgttt gtagattaat aatcattttg tttagaatta caaaatagtt tttaaatatt     5100

gtctgagaaa agccaaagtt aatgcaacct agtggaaact gtaagaccat ttgagtattg     5160

tttgttttat tgatgcattt ggattttgtt gtttgatgga atttgagcca aaaaaaaaat     5220

acgcaggctt tcctatttct acaactgatt gtacttatgc attttgtacc agtggaactt     5280

tttatactgg agattaaaaa aaaaatggaa atttttgtgg cttgctctgg tgggcccctg     5340

acaatgactg atttcaagtt tgatttcggg ttgattgatt gattgattga tagaaagaaa     5400

gttgcttttc ttttgagaat taaaaacttt ggcttgattt cttttttccc tttgcttata     5460

tctagcatta gaattttgtc ttaaaataac agcggtaagt ttcacttttt attctgtatt     5520

gtgcagttac acaataaggt aattagattt agaagtactc agtcacttta agtggataaa     5580

tgtattagtt aaaactttag ggtttgcttt tttgctgttt agatcaaagt tttttctgat     5640

tcttctgtcc tcattgtgaa cataaccgtg tagttgaaac agtcaaactt atttttgtaa     5700

tgtatgttat tgtgtgatgc agttttttgc ttctgtctcc aatattaaac cattttccta     5760

ata                                                                   5763


<210> 854
<211> 2236
<212> DNA
<213> Homo sapiens

<400> 854
ctactcatgg cgcctgccct ggttggcgat gtgttaccaa cgtctggcct gtcccagccc       60

aaggctccgc gtggcgacca ggcccagcac tgggaggctg tgcagagcgt ggcgtttact      120

gcttattgct actctgcaga ggttggcaac atctgacccg ctctactggc aggaaacagg      180

ctcgggggca ttgggaaaac gatcaaggcc acttggctgg acactggcgg agcctcgcac      240

tcaaacctgt cgggcctcaa ctccgtgcca ggccaacaag ttgccctggg cagttcaagc      300

tggggataag ggggatgggg agcaggaaga cagcagcaag gatgcgatcc cgaaggaact      360

ttcctcctca gactgctcca tgtccatgtg gggcaggtcg ctgaagagtt cgaaaccgtg      420

ctcagcaccg cgtttggggc atgtgagacc gagaggcttt gggaaactga cgccgctgtg      480

agaacgagtt tagcggagtc tatggacgct gcgagcttgt ggccacaaga gggcgccccg      540

gagcacggcc cagtccccgc ccccgctgga tggggcccgg cctcttccca gcgttcctcc      600

tccggcccca ggtcaccgcc agcacgcgcc tgcttcccgt ctgcgcgagt ccacgcagct      660

ccccaggccc ttcaccagca cagcagcagc aggcatggca gcaagcgtgg agcagcgcga      720

gggcaccatc caggtgcagg gccaggccct cttcttccga gaggccctgc ccggcagtgg      780

gcaggctcgc ttctctgtac tgctgctgca tggtattcgc ttctcctccg agacctggca      840

gaacctgggt acactgcaca ggctggccca ggctggctac cgggctgtgg ccattgacct      900

gccagggctc aagggcgagc ctcctgccca ggagcctctc ttgtcccaat ccagggccag      960

cttcctggcg gctgtggtgg atgccttgga gctgggcccc ccggttgtga tcagtccatc     1020

actgagtggc atgtactccc tgcccttcct cacggcccct ggctcccagc tcccgggctt     1080

tgtgccagtg gcccccatct gcactgacaa aatcaatgct gccaactatg ccagtgtgaa     1140

gactccagct ctgattgtat atggagacca ggaccccatg ggtcagacca gctttgagca     1200

cctgaagcag ctgcccaacc accgggtgct gatcatgaag ggggcggggc acccctgtta     1260

cctggacaaa ccagaggagt ggcatacagg gctgctggac ttcctgcagg ggctccagtg     1320

aagcccagca ctgctgcagg gggtgggctg cctgcctgct ctgagctctc tcttgcacgc     1380

tctctcttct ctcccaggct ctggctcatg cacatgcaac aggtgcgtct gtctatatgt     1440

ctgggttctt gtcttttgtg gtctgtttgt cttttctacc tctttctctt gcagtgatag     1500

actgaggggg taaaatcaag agaaaaaact ctcaggaatc aaggaacata atcctgtgga     1560

gggtaatcca ttacatgagc ttctcctgtt cttccacttt cctgcctggc tttcactcct     1620

tcccctgctc tgcccagcct ttccctccca cccactcctc cttctgcaaa tgccctgaag     1680

gccagccctt accccaacac ccacttcccc acctccttag gccccagata catacatgcc     1740

cacatgcacg cttacatgtt tagagccatc cttgtttcca aatatgaccc ttcgcttgag     1800

ggcaactgca taggtacatc taactctgga ctggcatgca cattgtcatg tgcagctttg     1860

catatacaca catgcataca tgagcctcca cacaagcact tgcacacatg tggactccta     1920

accatgctaa cctcactggc tgggaaggtg gggaccccat gggccagccc ttgcaggagg     1980

cccttttgca aggcttaggg tgtggccagc cctgaaagct acttggacac aggtttcagc     2040

tggccccagc ccagaagtga cccccagaaa gggagggcca ccgctttgcc ccctgctttt     2100

acccttcctt ctgggtgctc tacacctcag gttaccaggc ctgaggcatc tcagccaagc     2160

ttgtttcctg ctctgaggct tgtggggtgg gagccagagt ggaggtcggt gaaataaagt     2220

gatgcaatta gacccc                                                     2236


<210> 855
<211> 860
<212> DNA
<213> Homo sapiens

<400> 855
gtcccggccc gagcctccgg ccgcccgccg ggtttgtccc gcgatccccg accatgcccg       60

ccgacctcag cggtacttgg accctgctca gcagcgacaa cttcgagggc tacatgctgg      120

ccctagatgg agtctcgctc tgttgctcag gctggagtgc agtggtgtga tcttggctca      180

ctgcaacctc cgcctcctgg gttcaagcaa ttctcctact tcagcctcca aagtagctgg      240

gattacaggt atgtgccacc atgcccggct aattttgtat ttttagtaga gatggggttt      300

ctacatgttg atcaggctgg tctcaaactc ctgacctcag gtattgactt tgccactcgt      360

aaaatagcca agttgctgaa gccacagaaa gtgattgagc agaatgggga ttcttttacc      420

atccacacga acagcagcct aaggaactac tttgtgaaat ttaaagttgg agaagaattt      480

gatgaagata acagaggcct ggacaacaga aaatgcaaga gtttggttat ctgggacaat      540

gacaggctca cctgtatcca gaagggagaa aagaagaaca gaggctggac ccattggatc      600

gaaggagaca aactccacct ggaaatgttc tgtgaaggtc aagtgtgcaa acagacattc      660

cagagagcct gatccacatc cagcagcaga gcccacttgt ggctgcagct ttatgccaaa      720

ttatattgca gactgaacag acgtttatct atcccatttg gcgacgagga ctcgtggctg      780

gagagagcca cacagcgtgt aacctgaagt catctagatt atggggaaac tgctcagctt      840

caataaacct gtccaaatga                                                  860


<210> 856
<211> 2912
<212> DNA
<213> Homo sapiens

<400> 856
tttgttgttg acaactgtca gcttcgacct ccttctcctc acaaccccgt ctaaatgggg       60

tttgtaatcc tccttcccac ccactctctt cactccctgg ggcaagaatg ttgactcctg      120

ctctccgtca cctgtcagga tccatcctcc tgtcactggc ttatatggac acgtcagccc      180

accgtcacgt gaccgcaggc tgctaaaaac agctccagca cccactccaa accagggcct      240

gaaacaatgt cctccaccga gagaaacgta aaggacactt gatcacacaa tccctggaat      300

aatatccagg aaacacttgc tggagccact cgcagcaccc ttccctggca gcacacttgg      360

ggacagcgag gagatgagcg catctctgaa ttacaaatct ttttccaaag agcagcagac      420

catggataac ttagagaagc aactcatctg tcccatctgc ttagagatgt tcacgaaacc      480

tgtggtgatt ctcccttgtc agcacaacct gtgtaggaaa tgtgccagtg atattttcca      540

ggcctctaac ccgtatttgc ccacaagagg aggtaccacc atggcatcag ggggccgatt      600

ccgctgccca tcctgtagac atgaagtggt tttggataga catggggtat atggacttca      660

gaggaacctg ctggtggaaa atatcattga catctacaag caggagtcca ccaggccaga      720

aaagaaatcc gaccagccca tgtgcgagga acatgaagag gagcgcatca acatctactg      780

tctgaactgc gaagtaccca cctgctctct gtgcaaggtg tttggtgcac acaaagactg      840

ccaggtggct cccctcactc atgtgttcca gagacagaag tctgagctca gtgatggcat      900

cgccatcctc gtgggcagca acgatcgagt ccagggagtg atcagccagc tggaagacac      960

ctgcaaaact atcgaggaat gttgcagaaa acagaaacaa gagctttgtg agaagtttga     1020

ttacctgtat ggcattttgg aggagaggaa gaatgaaatg acccaagtca ttacccgaac     1080

ccaagaggag aaactggaac atgtccgtgc tctgatcaaa aagtattctg atcatttgga     1140

gaacgtctca aagttggttg agtcaggaat tcagtttatg gatgagccag aaatggcagt     1200

gtttctgcag aatgccaaaa ccctgctaaa aaaaatctcg gaagcatcaa aggcatttca     1260

gatggagaaa atagaacatg gctatgagaa catgaaccac ttcacagtca acctcaatag     1320

agaagaaaag ataatacgtg aaattgactt ttacagagaa gatgaagatg aagaagaaga     1380

agaaggcgga gaaggagaaa aagaaggaga aggagaagtg ggaggagaag cagtagaagt     1440

ggaagaggta gaaaatgttc aaacagagtt tccaggagaa gatgaaaacc cagaaaaagc     1500

ttcagagctc tctcaggtgg agctgcaggc tgcccctggg gcacttccag tttcctctcc     1560

agagccacct ccagccctgc cacctgctgc ggatgcccct gtgacacagg gggaggttgt     1620

acccactggc tctgagcaga ccacagagtc tgaaactcca gtccctgcag cagcagaaac     1680

tgcggatccc ttgttttacc ctagttggta taaaggccaa acccggaaag ccaccaccaa     1740

cccaccttgc accccaggga gcgaaggtct ggggcaaata gggcctccag gttctgagga     1800

ttcgaatgta cggaaggcag aagtggcagc agccgcagcg agtgagaggg cagctgtgag     1860

tggtaaggaa actagtgcac ctgcagctac ttctcagatt ggatttgagg ctcctcccct     1920

ccagggacag gctgcagctc cagcgagtgg cagtggagct gattctgagc cagctcgcca     1980

tatcttctcc ttttcctggt tgaactccct aaatgaatga tattcattcc aactgctgcc     2040

cctctgtctg cctggctgag atgcatgtgg gcagcaggaa gcccaagtga aattaatatt     2100

atgcagatga tgaaagggac ctctgaacag gatttctgca aaaatagccc caaactgcaa     2160

ttccatatga cttatctaac atcttggggg gaaagaatat tttgagaaaa tagttgcaga     2220

aagcactgga aataataaac ttgatcttat acaaatcttc tattgtgtgg aaaatgttgt     2280

gaagggtgtg taggtgtggt acatgtgtat gtcactaaca agtggcaaat ggtgaaaaaa     2340

gtggtcacta tgcttttgtc tctcataggc actgactttt tgttattata ttatggtagc     2400

tttcatttcc tttactcttt aacagtgcag gtggtcagtg aaaatcagtg tcaactcaga     2460

agtgactgat ttatcaatac atggacaaaa agtaaatcat tgaccaaagc tatgaaatgt     2520

ttcacaaagt tttcctcttt tgcataacag atgtcactgg atgtacattc agaaatgttc     2580

tttgaatttg gtgacacttt catggtccag aaagctgaag gcctgggcat ctcttgtgac     2640

atttttctaa tattagtttt agattttcac gtattaggca ctttagttga atcttccagc     2700

aaaagctgtc tactttctct tttattcact gtggcaccaa tctggtaaat tgtagaacaa     2760

ttgcatgtgt ttaaatatat atacaaacat atcacacatt aaatatatat atatttaaat     2820

catgctttgt taatatttgt cccaccataa tgcctccttc agaacataag tgtaacttta     2880

tatgaactct taaataaatg atgtttttaa aa                                   2912


<210> 857
<211> 1878
<212> DNA
<213> Homo sapiens

<400> 857
atatgaatca ttactcctta cccaggcagt aatgttcccg aagttttctc ttcgttctat       60

gtttcatgga gctggaggag ggaatgatat tcagtggtgt ttttctcagg tgaaaggagc      120

agtagatgat gatgtagcag aagcagatat aatttctaca gtagaattta atcattctgg      180

agaattacta gcaacaggag ataaaggtgg tagagttgtc atctttcaac aggagcagga      240

gaacaaaatc cagtctcata gcagaggaga atataatgtt tacagcacct tccagagcca      300

tgaaccagag tttgactact tgaaaagttt agaaatagaa gaaaagatca acaaaattag      360

gtggttaccc cagaaaaatg ctgctcagtt tttattgtct accaatgata aaacaataaa      420

attatggaaa atcagtgaaa gggacaaaag accagaaggg tataacttga aagaggagga      480

tggaaggtat agagatccta ctacagttac tacactacga gtgccagtct ttaggcctat      540

ggatctaatg gttgaggcca gtccacgaag aatatttgcc aatgctcata catatcacat      600

caactcaatt tctattaata gtgattatga aacatattta tctgcagatg atttgcggat      660

taatctttgg catctggaaa ttacagacag gagttttaac attgtggata tcaagcctgc      720

caatatggaa gagctaacag aggtgattac agcagcagaa tttcatccaa acagctgtaa      780

cacatttgta tacagcagca gtaaaggaac tattcggcta tgtgacatga gggcatctgc      840

cctctgtgat agacattcta aattgtttga agaacctgaa gatcccagta acaggtcatt      900

tttttccgaa atcatctcct ctatttcgga tgtaaaattc agccatagtg gtcgatatat      960

gatgactaga gactatttgt cagtcaaaat ttgggactta aatatggaaa acaggcctgt     1020

ggaaacatac caggtgcatg aatacctcag aagtaaactc tgttcactgt atgaaaatga     1080

ctgcatattt gacaaatttg aatgttgttg gaatggatct gacagtgttg tcatgactgg     1140

atcttacaat aatttcttca gaatgtttga cagaaacaca aagcgagaca taaccctaga     1200

agcatcgcgg gaaaacaata agcctcgcac agttctgaag cctcgcaaag tctgtgcaag     1260

tggcaagcga aagaaagatg aaataagtgt tgacagccta gacttcaata agaaaatcct     1320

tcacacagcc tggcacccca aggaaaatat cattgccgta gctactacaa acaatctgta     1380

tatatttcaa gacaaagtga attagggttg gcattcctag cagaagaacc cacttcctgc     1440

ttagttgaga tagttgaatc tagcattcgt tcctataaaa gagagaggtc cattgtggcg     1500

cccctttcca gtgtttgaca gtgtgccatt cgacaacaca ttgttatagc tacatggaga     1560

aagctctgtg gattcatcac tgtggtgttc tccatgtctg ctagccattt aggtaagggt     1620

agggcacttt taatttaaat gacttcttgc accatcttgc ctaatggact agattggact     1680

gtatcaacat tgatttactc cactttttat gccttccatt gtgatgacgt caaacacagt     1740

gaaagccttc agtcatgcta tgggatttaa ttgtgtatcc tcattactgt atcatttgtg     1800

gggtacaccc cttccccctt tttttaaatt aaatacagct cattcttact gtggcttgta     1860

gcattcctcc tcttctgg                                                   1878


<210> 858
<211> 887
<212> DNA
<213> Homo sapiens

<400> 858
acctccggaa accgtagatt ccgggcggtc ggagccgccg ggagctgtag ttctcccgcg       60

gctcagagaa gtaggcagag agcggacctg gcggccgggc agcatggcgg ggctggagct      120

cttgtcggac cagggctacc gggtggacgg gcggcgcgcc ggggagctgc gcaagatcca      180

ggcgcggatg ggcgtgttcg cgcaggctga cggctcggcc tacattgagc agggcaacac      240

caaggcactg gctgtggtct acggcccgca cgagatccgg ggctcccggg ctcgagccct      300

gccggacagg gccctagtga actgtcaata tagttcagcg accttcagca caggtgagcg      360

caagcgacgg ccacatgggg accgtaagtc ctgtgagatg ggcctgcagc tccgccagac      420

tttcgaagca gccatcctca cacagctgca cccacgctcc cagattgata tctatgtgca      480

ggtgctacag gcagatggtg ggacctatgc agcttgtgtg aatgcagcca cgctggcagt      540

gctggatgcc gggataccca tgagagactt tgtgtgtgcg tgctcagctg gcttcgtgga      600

cggcacagcc ctggcggacc tcagccatgt ggaggaagca gctggtggcc cccagctggc      660

cctggccctg ctgccagcct caggacagat tgcgctgctt gagatggatg cccggctgca      720

cgaggaccac ctggagcggg tgttggaggc tgctgcccag gctgcccgag atgtgcacac      780

cctcttagat cgagtggtcc ggcagcatgt gcgtgaggcc tctatcttgc tgggggactg      840

accacccagc cacccatgtc cagaataaaa ccctcctctg cccacac                    887


<210> 859
<211> 4567
<212> DNA
<213> Homo sapiens

<400> 859
agaccaggta gtcgctgccc agccggtcag gacgtgggac gcaaggggca atcctgcccg       60

gttcgcaggt ccgaggcggg cgcggtggcc cttcgggccc cgccccgccc cgccccgccc      120

cgccccgccc accggcagcc cggccacgac ccaagcggag gccgcgccga cgcctgcgca      180

atgtatgcgg agagccacca ccgcctccgg tcccgactcc gatgatggcg gacggcgccg      240

cagctggcgc tggcggcagc ccatccttga gagagctgcg ggcacggatg gttgctgcag      300

caaacgagat tgctaaggaa aggaggaagc aagatgtggt taatcgtgtt gcaacccatt      360

cctcaaatat aagatcgaca tttaaaccag taatcgatgg atccatgctt aaaaatgaca      420

taaaacaaag attagcaaga gagcgcagag aggagaaaag gagacagcaa gacgccaata      480

aagaaacaca actacttgaa aaagaaagaa agaccaagct ccaatatgaa aaacagatgg      540

aggaaagaca gagaaagctg aaggagcgaa aagagaaaga agaacaacgg agaatagctg      600

cagaagaaaa aagacaccag aaggatgaag cacaaaagga aaaatttaca gccattcttt      660

atcgtacttt ggaacggagg agacttgctg atgattatca gcaaaaaaga tggtcatggg      720

gaggctctgc aatggcgaat tctgagagca aaactgccaa taaacgatct gcatctactg      780

aaaaacttga acagggtact tctgctttaa tcagacaaat gcctttgtca tctgcaggcc      840

ttcaaaattc cgttgccaaa aggaaaacag acaaggagag aagctcatct ttaaatagaa      900

gagatagtaa cctacattcg tctactgata aagaacaagc cgaaaggaag ccacgtgtta      960

caggcgtcac caattatgta atgcagtatg tcactgtacc cttgcgtaaa tgtactagcg     1020

acgaattgag ggctgttatg tttcccatgt cgacaatgaa aatacctcct caaacaaaag     1080

tagaagagtc tcccttggag aaagtagaga cacctcccaa ggcaagtgtg gatgcacccc     1140

cccaggtgaa tgtggaagta ttctgcaaca caagcatgga agcgtccccc aaggcaggtg     1200

tgggcatggc ccctgaggtg agcacggact cattccctgt ggtgagcgtg gacgtgtcgc     1260

ctgtggtgag cacatatgat tctgagatga gcatggacgc atcccccgag ttgagcatag     1320

aagcactccc gaaggtggac ctggaaacag ttcccaaggt gagcatagta gcatccccgg     1380

aggcgagcct ggaagcaccc ccggaagtga gtctggaagc actgccagag gtgagcgtgg     1440

aagcagcccc agaggggagc ctggaagcac ctcccaaggg gagcgcagaa gtagccccca     1500

aggagagtgt gaaagggtca cccaaggaga gcatggaggc atctcctgag gcgatggtga     1560

aagcatcccc caagacatcc cttgaagcaa gcatggaagc atctcccaag gcaaaagcga     1620

gagacgctcc aaagaaatca gaaatggaca aacaggcctt aatccctatt gccaagaagc     1680

gtctatcatc atacactgag tgttataaat ggtcatcatc tcctgaaaat gcttgtggtc     1740

tgccgtctcc catcagcact aacaggcaaa tccaaaagaa ctgccctcca tcaccattac     1800

cacttatttc aaaacagtca ccacagactt cttttcctta taaaataatg cctattcaac     1860

acaccctgtc tgtgcaaagt gcatcaagta ctgtcaaaaa gaaaaaagaa acagtttcta     1920

aaaccactaa cagatgtgag gctttgagcc aaaggcatat gatctatgaa gagtctggta     1980

ataagagtac tgcaggtatt atgaatgccg aggcggcaac aaaaattttg acagaattgc     2040

gccgccttgc tcgtgaacaa agagaaaaag aggaagaaga aagacaacgg gaagaaatgc     2100

agcaaagggt cattaagaaa tcaaaagaca tggcaaagga agcagttgga ggccaagcag     2160

aagaccactt gaaactcaaa gatgggcagc aacaaaatga gactaaaaag aagaaaggat     2220

ggctggatca ggaagaccag gaagcaccac tgcagaaagg ggacgccaaa ataaaagctc     2280

aagaggaagc tgacaaacgc aagaaagaac acgagagaat tatgttacaa aatttacaag     2340

aacggttaga aaggaaaaag agaatagaag aaattatgaa gcggacaaga aagacagatg     2400

tgaatgcctc aaaggtcaca gaaacatcca gccatgacat atatgaagag gctgaggctg     2460

acaacgaaga aagcgacaag gactcattga atgaaatgtt tccatcagcc attctaaatg     2520

gcacaggctc acctaccaaa tttaaaatgc cgttcaacaa tgccaagaaa atgacacaca     2580

agctggtatt tctagaagat ggtaccagcc aggtccgtaa agagccaaaa acatatttta     2640

atggcgattt gaaaaacttc agacaaaaaa gcatgaaaga cacttcaata caggaagtag     2700

tttcaagacc atcttccaaa agaatgacca gtcacacaac gaaaaccaga aaggcggatg     2760

aaaccaacac caccagcaga tcctctgcac aaacaaaatc tgaaggattc catgacatct     2820

tgccaaagtc ctcagacacc tttagacaat aagagaagaa gcaaacctgt ttctcctcat     2880

ttggatatgt aaaccttact cagcctggga gatgaataca tcttccactc tggataactc     2940

aactcctggg cccatcagtc ctcaaatttt tctgcttctg acttgaacct ggtaaaggaa     3000

gtgacaccga aaaattgaaa gaaactgtca aaaggccact ttgatgtata tctcagatgt     3060

taaagtcatc ttattctctt gtgtctaagc aagagttcta agtaaagagt ggtttttgtt     3120

ttctttggaa aatcatcatt gtctctcatt cttgtgttgt cccaccaatg tgtttgctgg     3180

agtgagtgca tcaaggatgc tttcctgaaa ctgtaactgt ggagtttcta gaagaatctg     3240

attgcagaac taattctctt tcagtatata tttgaaatct taaagtaatg ctttttcttt     3300

ttctttttct tttttttttt tttgagacgg agtcttgccc tgtcgcccag gctgcagtgc     3360

agtggcacaa tctcggctca ctgcaacctc cgcctcctca tctcaagcaa ttctcctgtc     3420

tcagcctccc cagtagctgg gattacaggc atgtgccacc acacctggct aatttttttg     3480

tattttagta gagatagggt tttaccatgt tcaccaggct agtctcgaaa tcctggcctc     3540

aagagatcca cccgtcttgg cctcccaaag tgttgggatt acaggtgtga gccactgcac     3600

ccagccaagt aatgcttttt ctgtgtacca gtgacaattt tgacagctaa aaactcacag     3660

ttgatcttgt agagaacaga atagattatg caagggccgc aggatcgctc acaagagctg     3720

tcagattgtt tctaatataa aaataccaaa ggttgcaaaa tccagcaaat tgtattttac     3780

tgtgatatat gtatattttt aactctaccc atctgtgcca gtgagtacac aggcactaat     3840

aacctgaaat gctgggagtc ctgtaaagcc ccatcttgga acagtcagca cctttcatgc     3900

tcttgtcagt gtttcctttt gaaggacata ttggtgttta tctacagaaa catatattat     3960

ttttattgtg tacataaagg agtatatggc tgttgtcccg tggggtatgt ttaattcctc     4020

taaatgttta aagtactttt ctgcctgtac tctccagttc tgtcgttgag tatacactca     4080

ggcttgagat acaaccaaaa tttgcttgcc tttctctagc cactggctgc cagtgagttc     4140

gtgtgatggg cacacagaaa tgcacacaga tgtacataca cgtatgtatg cacacacagt     4200

atatgattcc ataaaattca aatgcagatt aattctccta atgagttttc agtgttgaat     4260

cgtaaatagt ctgaagcagg ccagtgttcc ttttggctgc cagtcttgga ttagtaaaag     4320

gaggtaattc tttcagattc cctggttctt tgccactcag agtattgtac ttttgatata     4380

gaatagagaa ggttaccttt ggtttaaaaa ctatttttat atactagctc tttcatgtat     4440

aaaacagaga caatcatcct aacaaaagag ttcctgttat ttttctgcac aaatgtcttg     4500

tgttgaaaca ctgttacagt tccatataaa tgtgtgctat ataaaataaa ctttggagat     4560

aaaacaa                                                               4567


<210> 860
<211> 6817
<212> DNA
<213> Homo sapiens

<400> 860
atgtgctcga cgcccggaat gccggcgccg ggggcctcgc tggccctgcg ggtgtccttc       60

gtggacgtgc atcccgatgt gatcccggtg cagctgtggg ggctggtggg cgagcggcgg      120

ggcgagtacc tgcggctgag ccgggaaatc caggaagcgg cggccacgcg cggccagtgg      180

gcgctgggca gcgcctcggc ctcgcccggc gagctgtgcc tggtgcaggt cgggcttttg      240

tggcaccgct gccgcgtggt cagccggcag gcacaggaga gccgtgtctt cctgctggac      300

gagggccgca ccatcacggc cggagcaggc tcgctggcgc ctgggcgcag agagttcttc      360

aatttgccct cggaagtgct gggctgcgtg ctagcgggcc tggtgccggc aggctgcggc      420

gcgggctcag gcgagccgcc gcagcactgg cccgccgacg ccgtggactt ccttagcaac      480

cttcagggca aggaggtgca cgggtgcgtc ctggacgtgc tgctgctcca tcgcctggtc      540

ctcctggagg tgcctgatgt gttccaacag atgcgggagc tgggcctggc tcggcgggtg      600

cccgacagcc tcttccgttc gctgctggag cgctatctca cagcggccac tgctagcgtg      660

ggctccgggg tcccggttct ctcgcgagtc ccgctcaagc aaaagcagcc tggtctggat      720

tacttctatc cccagctgca gctgggcgtg acggaggccg tggtcataac ccaagtgtgc      780

catccccacc gcattcactg ccagctccgc agcgtctcgc aggagatcca ccgcctctcc      840

gagagcatgg cccaggtata ccggggttcc acggggacag gggatgagaa ctctaccagt      900

gccacctggg aggagaggga ggagagccca gataagccgg gctctccgtg tgcatcctgt      960

ggcctggatg gacattggta cagagcactg ttgcttgaga cttttcggcc ccagcgctgt     1020

gcccaggtgc ttcatgtgga ctatggaagg aaggagttag tgagttgcag cagccttcgg     1080

tacttgctgc ctgaatattt tcgaatgccg gtggtgacct acccttgtgc tttgtatgga     1140

ctctgggacg gtgggagagg ctggtctcgg tcacaggtcg gtgacctgaa gacactgata     1200

ctaggcaagg cagtgaatgc aaagattgaa ttttattgct cctttgagca tgtgtattat     1260

gtcagcctgt atggagaaga tgggattaat ctgaaccgtg tgtttggagt acagtcgtgt     1320

tgcttggctg accgagtcct tcagagccag gcaacagagg aggaggaacc agaaacatct     1380

cagtctcagt ctcctgctga agaagtagat gaagagattt cactcccagc cttaagatct     1440

atcaggttaa agatgaatgc cttctacgat gcgcaggtag agtttgttaa aaatccttct     1500

gagttttgga ttaggttgag gaaacacaat gtcaccttca gtaagctgat gaggagaatg     1560

tgtggtttct attcctctgc cagtaagctg gatggtgtag ttttgaaacc tgaacctgat     1620

gacctttgct gtgtcaagtg gaaagaaaat ggttattata gggccatagt caccaaattg     1680

gatgacaaga gtgtggatgt attcttagtt gaccgaggca attcggaaaa tgtggactgg     1740

tatgacgtaa ggatgctgct tcctcagttt aggcagctac caatattggc tgtgaagtgc     1800

accctggctg atatttggcc tttgggaaaa acttggagcc aggaggcagt ttcctttttt     1860

aaaaagactg tgctccacaa agaattagtc atccatattc ttgataaaca ggatcatcaa     1920

tatgttattg agattcttga cgaatcaaga acaggggaag aaaacattag taaggtaatt     1980

gcccaagctg gatatgccaa gtatcaggaa tttgaaacaa aggaaaatat cctggtaaat     2040

gcccactccc cagggcatgt ttcaaaccac tttactacgg agagtaacaa aatacctttt     2100

gccaagactg gagaaggaga gcagaaagcc aagagagaga ataaaaccac atctgtttca     2160

aaagctttga gtgacacaac agttgtaaca aatggttcaa ctgaactagt tgtgcaggaa     2220

aaagtgaaaa gagcatctgt ttattttcct cttatgcaga attgcttgga aattaagcca     2280

ggctcctcta gtaaaggaga gctggaagtt ggaagtacag tagaagtcag agtgtcttat     2340

gttgaaaacc ctggctattt ctggtgtcag ctgaccagga acatacaagg acttaaaact     2400

ctaatgtctg atattcagta ctattgcaaa aatacagctg ctcctcacca gagaaacacc     2460

cttgcttgtt tggctaagcg aacagtaaac agacagtggt ccagagcact tattagtggg     2520

atacagtctg tggagcatgt caatgtaaca tttgtagatt atggagacag agaaatggta     2580

tctgtgaaga atatttattc aattagtgaa gaatttctga aggttaaggc acaggctttt     2640

aggtgcagtc tttataattt aattcaacca gttggccaga atccctttgt ttgggatgta     2700

aaggcaatac aagctttcaa tgaatttata gataatgcat ggcaaaaaaa tctagaatta     2760

aaatgtacaa tatttgctct ggcttcaatt aatgaagaac tgtttaacat tgtggatttg     2820

ctaaccccct ttcagagtgc atgccatttc ttggtagaaa agagacttgc aagaccagta     2880

aaacttcaga agcctttgga gtcctctgtt cagctacatt cctacttcta ttctacacat     2940

gatatgaaaa ttggaagtga agaattagtt tatataacgc atattgatga cccttggaca     3000

ttttattgcc agctggcaag aaatgcaaat attttagaac agttgtcatg tagtattaca     3060

caattaagta aagttttgct gaatttaaaa acatctccct tgaaccctgg aaccttgtgc     3120

cttgccaagt atactgatgg aaactggtat aggggcatag taatagagaa agagccaaag     3180

aaagtcttct ttgttgattt tgggaatatt tatgtagtaa caagtgatga tctgcttcca     3240

atacctagtg atgcatatga tgtcttactt ttgcccatgc aagctgtcag atgttcatta     3300

tctgatattc ctgatcatat accagaagaa gtggtggtgt ggtttcagga gactatttta     3360

gataagtcat tgaaggcttt agttgtagca aaagatccag atggaacact gattatagaa     3420

ctatatggtg acaatattca aattagtgct agtattaata agaagttggg gctacttagt     3480

tacaaagata gaataagaaa aaaagaaagt gaagtcctct gttctacaac tgaaactctt     3540

gaagaaaaaa atgagaatat gaagttgcca tgtacagagt atttaagtaa atcagtaggg     3600

tacaagttac ctaataaaga aattttggaa gagtcatata aacctcagat caactcatca     3660

tacaaggaac tcaaactttt acaaagttta acaaaaacaa acttagtcac tcaatatcaa     3720

gactctgtgg gaaataaaaa tagtcaagtg tttccattaa caacagaaaa gaaagaagaa     3780

atttctgctg agacaccctt gaaaacagca agagtagaag ctactctttc agagagaaaa     3840

ataggagatt catgtgacaa agatttgcct ctgaaatttt gtgagttccc acagaagact     3900

ataatgcctg gatttaaaac aactgtatat gtttctcata taaatgacct ttcagacttt     3960

tatgttcaac taatagaaga tgaagctgaa attagtcatc tttcagagag attaaacagt     4020

gttaaaacaa ggcccgaata ttatgtaggt ccacctttgc aaagaggaga tatgatatgt     4080

gctgttttcc cagaagataa tttatggtat cgtgctgtga tcaaggagca acaacccaat     4140

gaccttctct ctgtgcagtt tatagattat ggcaatgttt ctgtggttca tactaacaaa     4200

ataggtaggc ttgaccttgt taatgcaata ttgccggggt tgtgcattca ttgctccttg     4260

cagggatttg aggttcctga caataaaaat tctaagaaaa tgatgcatta cttttcccaa     4320

cggaccagcg aggctgcaat aagatgtgaa tttgttaaat ttcaagacag atgggaagtt     4380

attcttgctg atgaacatgg gatcatagca gatgatatga ttagcaggta tgctctcagt     4440

gaaaaatctc aagtagaact ttctacccaa gtaattaaaa gtgccagttc aaagtctgtt     4500

aacaaatcag acattgacac ttcagtattt cttaactggt ataatccaga aaaaaaaatg     4560

ataagagctt atgccactgt gatagatgga cctgagtact tttggtgtca gtttgctgat     4620

acggagaaac ttcagtgttt agaagtagaa gtacagactg ctggagaaca ggtagcagac     4680

aggagaaatt gtatcccatg tccttatatt ggagatcctt gtatagtaag atacagagaa     4740

gatggacatt attatagggc acttatcact aatatttgtg aagattatct tgtatctgtc     4800

aggcttgtgg actttggaaa cattgaagac tgtgtggacc caaaagcact ctgggccatt     4860

ccttctgaac ttctgtcggt tcccatgcaa gcctttccat gttgcctctc agggtttaac     4920

atttcagaag gattatgttc tcaagaggga aatgactatt tctatgaaat aataacagaa     4980

gatgtgttgg aaataacaat actagaaatc agaagggatg tttgtgatat ccctttagca     5040

attgttgact tgaaaagcaa aggtaaaagt attaatgaga aaatggagaa atattctaag     5100

actggtatta aaagtgctct tccctatgaa aatattgact cagagataaa gcagactctt     5160

gggtcctaca atcttgatgt aggacttaag aaattaagta ataaagctgt acaaaataaa     5220

atatatatgg aacaacagac agatgagctt gctgaaataa ctgaaaaaga tgtaaacatt     5280

attggaacca aaccaagtaa cttccgtgac cctaaaactg ataacatttg tgaagggttt     5340

gaaaacccct gcaaagataa aattgatact gaggaactgg aaggtgaatt agagtgccat     5400

ctggttgaca aagcagagtt tgatgataaa tacctgatta caggatttaa cacattacta     5460

ccacatgcta atgaaacaaa ggagatacta gaactgaatt cacttgaggt gccgctttct     5520

cctgatgatg aatcaaaaga attcttagaa ctggaatcta ttgagttaca gaattctctg     5580

gtggtggatg aagaaaaagg ggagctaagc ccggtgccac cgaatgtgcc actctcccaa     5640

gagtgtgtca caaaaggcgc catggagcta tttacactgc agcttcctct cagctgtgaa     5700

gctgagaaac agccagaact agaactacct acagcccagc tgcctttaga tgacaagatg     5760

gatcctttgt ctttaggagt tagtcagaaa gcacaggaat ccatgtgtac tgaggacatg     5820

agaaagtcaa gttgtgtaga atcttttgat gaccagcgca ggatgtcatt gcatctacat     5880

ggagcagatt gtgatcctaa aacacagaat gaaatgaata tatgtgaaga agaatttgta     5940

gagtataaaa acagggatgc catttcggca ttgatgcctt tgttctctga ggaagaaagc     6000

agtgatggaa gcaagcacaa taatggttta ccagatcata tctcagctca actacagaac     6060

acctacactc tgaaagcctt tactgttgga tctaaatgtg ttgtgtggtc aagtctaaga     6120

aacacatggt ctaaatgtga gattttagaa acagctgaag aaggaacaag ggttttgaac     6180

ctttcaaatg gtatggagga gatagtgaac cctgagaatg tctggaatgg catacccaaa     6240

ttggataaga gtccacctga gaaaaggggt ttggaggtga tggagattta accgtggatc     6300

tatagctgtg gccaatcagt cagaagctgc ccttgaacaa gtggcatctt acgcagacca     6360

acagagtatt tgagaaaatt gaaaacatgt aaccacaaga agttgtcatt ttcaaaaact     6420

tctatatagg tggaaaacaa attaggtctc aggttgatgg tggggtgtgt ttatagtgat     6480

cctgttatat atacagatct gggatctttc gtctttattg tcttacgttt ctaattagtt     6540

gggaggattt attttgctaa acagtttact aacacattac atttcaaaaa ctattttggt     6600

acctttcaaa tacagtgttt aaattaaaat agaaaaataa gggctcatga caagtacatt     6660

atttgattct acttaggata gctttttagc aggatctcct tcagaatttt tgtcttgact     6720

ttgaatcttt gcctgtttgt ctaaacattt gactaacatt ctgtttgaat ttggaagtat     6780

tctaatacaa gatttgaata aagtttatcc ttaaata                              6817


<210> 861
<211> 833
<212> DNA
<213> Homo sapiens

<400> 861
tggagccttt gcggcggcgc tgcccctccc ctggtccccg cgagctcgga gggcccggct       60

ggtgctgcgg gggccccggg aggttgaaaa ctaagcatgg ggaagagctg caaggtggtc      120

gtgtgtggcc aggcgtctgt gggcaaaact tcaatcctgg agcagcttct gtatgggaac      180

catgtagtgg gttcggagat gatcgagacg caggaggaca tctacgtggg ctccattgag      240

acagaccggg gggtgcgaga gcaggtgcgt ttctatgaca cccgggggct ccgagatggg      300

gccgaactgc cccgacactg cttctcttgc actgatggct acgtcctggt ctatagcaca      360

gatagcagag agtcttttca gcgtgtggag ctgctcaaga aggagattga caaatccaag      420

gacaagaagg agggtctcac tctgccaccc aggctggagt gcagtggcat gatcacagct      480

cactgcagcc tcaacctccc aaggcttagg tggtcctcct gcctcagccc cctgctaaga      540

ctacaggtca ccatcgtggt ccttggcaac aagtgtgact tacaggagca gcggcgtgta      600

gacccagatg tggctcagca ctgggccaag tcagagaagg tgaagctgtg ggaggtgtca      660

gtggcggacc ggcgctccct cctggagccc tttgtctact tggccagcaa gatgacgcaa      720

ccccagagca agtctgcctt ccccctcagc cggaagaaca agggcagcgg ctccttggat      780

ggctgaagag ctgccgttcc tctttcacga tcccagcccc atttcagtgt ctg             833


<210> 862
<211> 3456
<212> DNA
<213> Homo sapiens

<400> 862
gcccgctcgg ccgtggccgt gggagaggcg ccgggaggct gcgggcgcgg ggctccgggg       60

cgggggcggc gcgaacggcg cggacggcgc gggcgcgggg ggctgggtcc cggggcgctg      120

ctggggtgga cccccccgcc tcgaacttgg tacgcgccag cgagaggcca ggcccagccc      180

gggcggtaca atagggttgg gccgaggccg ggactgggcc ggcgccgggc ggggaacggg      240

ttcgcgaccg cagccgagag accccgggcg accggcacct ccgagactcg cgggccacct      300

gcctcgacct tccccggagc gcccccgcct ccgagtcgct acttgccggg ccgggccggg      360

ccgggcgtga tgcgccgcgg gacccctgtc ctggccactg gccgccgccg ccgccgccgc      420

tgagaccccg agacccccag tgacgccgca gccatggaga gcggcccgcg tgcggagctg      480

ggggcgggcg cacccccagc tgtggtcgcc aggacccccc cagagccaag accttctcca      540

gaaggtgacc cttccccccc accaccacca atgtcagccc tggtccccga cactcccccg      600

gacacccctc ctgccatgaa gaatgccact agctctaagc agctcccact ggaaccagag      660

agcccctcag ggcaggtcgg gcctaggcca gcccccccgc aggaagagtc cccttcctct      720

gaagcaaaga gcagaggacc caccccacca gccatgggcc cacgggatgc cagacctcct      780

cgaaggagca gccagccatc tccaacagca gtgccagcct ccgacagccc tcccaccaag      840

caagaggtga agaaggcagg agagagacac aagctggcaa aggagcggcg agaagagcgg      900

gccaagtacc tggcggccaa gaaggcagtg tggctggaga aggaggagaa ggccaaggcg      960

ctgcgggaga agcagctcca ggagcgccgg cgccggctgg aggagcaacg tcttaaagcc     1020

gagcaacgcc gtgcagccct ggaggaacgg cagcggcaga agctcgagaa aaacaaggag     1080

cgctatgaag cagccatcca acggtcagtg aagaagacgt gggccgaaat ccggcagcag     1140

cgctggtcct gggcaggggc cctgcaccac agctctccag gacataagac caatcgcagc     1200

ctgcagctga gcgcatggga gagcagcatc gtggatcgtc tgatgacgcc cactctctcc     1260

ttccttgctc ggagtcgcag cgcggtcaca ctgccccgca acggccggga ccagggtagg     1320

ggctgcgacc ctgggagagg ccccacgtgg ggccgggcag gggccagcct ggcgcgcggg     1380

ccgcaacccg accgcactca tccctctgca gccgtgccgg tgtgcccgcg ctcggcctcc     1440

gccagccccc tgacgccgtg cagcgtcacc cgaagcgtgc accgctgcgc ccccgccggt     1500

gagcgcgggg agcgccgcaa gcccaacgcc gggggcagcc ccgctccggt gcgccgccgg     1560

ccggaggcct cgccggtgca gaaaaaggag aagaaggaca aggagcggga aaacgagaag     1620

gagaagagtg ccctagcccg ggagcgcagc ctcaagaagc gccagtcgct gcccgcctcc     1680

ccacgtgccc gcctctctgc cagcaccgcc tctgagctca gccccaaatc caaggccagg     1740

ccatcctctc cctccacatc ctggcacagg cctgcctccc cctgccccag cccagggcca     1800

ggccacactc tgcctccaaa gccaccgtcc ccccgaggca ccactgcatc ccccaagggg     1860

cgggttcgga ggaaggagga ggcaaaggag agccccagcg ccgcagggcc cgaggacaag     1920

agccagagca agcgcagggc cagtaacgag aaggagtcag cagccccagc ctcaccggca     1980

ccttcgccgg cgccctcgcc caccccagcc ccgccccaga aggagcagcc ccccgcggag     2040

acccctacag acgctgctgt cttgacctca cccccagccc ctgctccccc ggtgacccct     2100

agcaaaccaa tggccggcac cacagaccga gaagaagcca ctcggctctt ggctgagaag     2160

cggcgccagg cccgggagca gcgggagcgc gaggagcagg agcggaggct gcaggcagaa     2220

agggacaagc gaatgcgaga ggagcagctg gcacgggagg ccgaggcccg ggcggagcgg     2280

gaggcggagg cccggaggcg ggaggagcag gaggcacgag agaaggcgca ggccgagcag     2340

gaggagcagg agcggctgca gaagcagaaa gaggaggccg aagctcggtc gcgggaagag     2400

gcggagcggc agcgtctgga gcgggaaaag cacttccagc agcaggagca agagcggcaa     2460

gagcgcagaa agcgtctgga ggagatcatg aagaggactc ggaagtcaga agtttctgaa     2520

accaagaagc aggacagcaa ggaggccaac gccaacggtt ccagcccaga gcctgtgaaa     2580

gctgtggagg ctcggtcccc agggctgcag aaggaggctg tgcagaaaga ggagcccatc     2640

ccacaggagc ctcagtggag tctcccaagc aaggagttgc cagcgtccct ggtgaatggc     2700

ctgcagcctc tcccagcaca ccaggagaat ggcttctcca ccaacggacc ctctggggac     2760

aagagtctga gccgaacacc agagacactc ctgccctttg cagaggcaga agccttcctc     2820

aagaaagctg tggtgcagtc cccgcaggtc acagaagtcc tttaagaggg tttgccttgg     2880

atccgggcac agttgtgagg gctcctctgc atcacctacc aggatgtctg gaggagaaaa     2940

agacagaaca aagatggaag tggcctgggc ccctgggggt gggtcctctc tgttgttttt     3000

aatctgcacc ttatagactg atgtctcttt ggccggagcc agatctgccc ctcagtgcat     3060

tcgtgtgctc gcacgcgcag acatcccttc tcccccatac acacatatac actcacagcc     3120

tctctggcct cttcccttgg ggaggggcca cctgtagtat ttgccttgat ttggtggggt     3180

acagtggatg tgaatactgt aaatagcttg tgctcagact cctctgcgtg gagagggtgg     3240

gtgcaggagg cagaccctcc ccccaaagcc ccctggggag atcttcctct ctctatttaa     3300

ctgtaactga gggggatccc aggtctgggg atgggggaca ccttgggcca caggatactg     3360

gttgcttcag gggtacccat gccccctgcc ctcgcctgga atcagtgtta ctgcatctga     3420

ttaaatgtct ccagaaataa agaataattc tgccaa                               3456


<210> 863
<211> 2428
<212> DNA
<213> Homo sapiens

<400> 863
gttacttcat agcattctga agacctgtcc accaattaca gggctcctta ctggaaaaac       60

caactgctgg ggagtgccaa gagtccctag caacaccctg cagcgtttga aatctgaggg      120

gaaaagactg tagtcagccc ttagtggatg agagcgccta tgctccagaa acagcaggct      180

cccaggatgg acaccccgcc ccctgaagaa cgcttagaga agcaaaatga aaaactgaac      240

aaccaggaag aggagacgga gtttaaggaa ctggacggtc tgagggaagc cttggcaaac      300

ctccggggac tgtcagagga ggagaggagc gagaaggcta tgcttcgctc ccgcattgaa      360

gagcagtccc agctcatctg catcctgaag cggaggtcag atgaggccct ggagcgctgc      420

cagatcctag agctgctcaa tgcagagctg gaggagaaga tgatgcagga ggctgagaag      480

ctcaaggccc agggtgagta cagtcggaaa ctagaggaac gctttatgac cctagcagcc      540

aaccacgagt tgatgctccg cttcaaggat gaatacaaga gtgagaacat caagctgagg      600

gaggagaatg agaagctgag gctggagaat agcagcctct tcagccaggc tctgaaggat      660

gaggaggcga aagtattaca gctcacagtc cggtgtgagg ccctcactgg ggagctagaa      720

acgctgaagg agaggtgtgc tcaggatgcc tgccaggcac aggcgcgcga gaaggagctg      780

ctggagctac agagccagca ggcctgcacc cacaccaagg agacagaaca gctgcgcagc      840

cagctgcaga ccctcaagca gcagcaccag caggctgtgg agcagatagc taaggcagag      900

gagacacaca gcagcctgag ccaggagctg caggccaggc tgcagaccgt cactagagag      960

aaagaggagt tgctgcagct gtccattgaa aggggcaaag tgcttcagaa caaacaggca     1020

gagatctgcc agcttgagga aaagttggag atagcaaatg aagacaggaa gcatgcgctg     1080

gagcggtttg agcaagaggc agtggctgtg gacagcaact tgagagtcag ggagcttcag     1140

cgcaaagtag atgggatcca gaaggcctac gatgaactca ggctgcagtc tgaagccttc     1200

aaaaagcaca gcttggatct tttaagcaag gagagagaac tcaatggcaa actccgccat     1260

ctctctccat agggaagttt ctgcttcctc tggcctgcaa ttcagaattc aaatatttgc     1320

gtcttagcat tatggcaaga gtaaagatga tatcccattt attatacttt caagcacaaa     1380

aggcaactca aagaaaagct actttactat gatattgttg ttattattgt aaagccatta     1440

ttaattttca tttctacacc tagaatacac aagatttgcc agatttcctt ctgtgcctta     1500

gaaatcttaa atttactagt agtatcttct cctacccata agttattaat tctcaacctc     1560

agatatcttc atttatgtta ggattttaaa ttagcagctt ctatgattta agtcaatcta     1620

agtgcagtga gatgtgccat tgtgaaaaat aattagcaca attacccact gtagatagtt     1680

aggcttatag tctcccatag ttgagattgt aagcaaacat gtatcagcat aatagcatga     1740

atgctttgca gaaaaaaaaa agtgtctgac tttattttat tttgcgctag cttggaaaat     1800

gattgagatc aagttcttta acaaagaagg tcaattttat tctgtatgag caatatgatt     1860

caaataagtt atacaaaaca acttttattt tttctgcaag cttagataat attccatttt     1920

ttggttttct ctttaaaaag aggatttaga tgtgcaataa tgcaaatatc agtagcttaa     1980

tttaatattg cacgatatgc taatagacaa ttagacaatt tggggtaaca aatcatagca     2040

gacgtgatct atagagtaac tcagaaattg ttttgtttct attagcatat tttttgtaat     2100

taagattttc cttttttaaa aaaatctaag ctgaacgtgt gtatgtatgc ttgcagcatt     2160

tttgtagtaa tacctacatt ttgtaagaat agttataaaa acatgatata tatatatgta     2220

aagttcttaa aaaagttctc aaaggtagtt atattttctt atcttcctgt aattaggtat     2280

tgatatataa acattattat gaatacctct caaaatagat tgtaatgtaa tatttttctc     2340

acccattttg ctgaaggcta ccaagttaca taatgaattt acttaaaaaa tatgacttgg     2400

tgccttttta gtaaaaccat ttccaagc                                        2428


<210> 864
<211> 2344
<212> DNA
<213> Homo sapiens

<400> 864
atttacgtgc cgtgcgtcgc cttggaaaca gaggagcatc cgcgacaccc ccgggagacc       60

caccccagct gctgctgcca cactcgcggg cgctgcccgg taatggcctg ggggagtccc      120

gagtccgacg cgccgctggc ctcagcctgg acgcggaccc ctccgcgagc gcgtctgtga      180

cccacggaac cggcaggcgc tctctgcttg tggcgcccag agggcggcgc tgacacgggc      240

gcgatccggg aggcgaggca gggcagggca ctttcgtccc ggggcgatcc caagagacgc      300

cggctctggg accctcgccg ggtcctcgtc ccgcagcctc ttctcggcct cccgcgatcc      360

tgcctgcgcc ctctgcccag gactcgtctc tcacgtcggc tccccgccag tctcgggagc      420

ctccgcttcc ctcggctccc gctagcccct cccgggacct ctccccctcc accccctccc      480

ccaccccgga ggccgggctg gacgcgaccc agagcctccg ccacccgctt ctgccactca      540

atggaggacg gtctgctgga gatcatgacc aaggacggcg gcgacatgcc ggcgcccctg      600

gaggtgtcca ccgtgccggc agtgggggac gtgatctccg gggagtacaa cggcggcatg      660

aaggaactga tggagcacct gaaagcccag ctgcaagccc tgtttgagga cgtgagggcc      720

atgagggggg ccctggacga gcaggcctcg cacatccagg tgctctcgga cgacgtgtgc      780

gccaaccagc gagccatcgt ctccatgtgc cagattatga ccactgcgcc ccgccagggc      840

ggcttgggcg tggtcggcgg caaggggagc ttccagagcg acccccaaga gccggagact      900

ccttcgcctg ggatcgggga cagcggcttg ctgggtcgcg atcccgagga cgaggaggaa      960

gaggaagaag agaaggagat gcccagcccc gccacaccct ccagtcactg tgagcgcccc     1020

gaaagcccct gtgctggtct ccttgggggg gacgggccac ttgtggagcc cctcgacatg     1080

cccgacatta ccctgctgca actggagggc gaggcctccc tgtgagggga ctccgtgggg     1140

cactaccttc ccgggctgtc tttgggtttc cgagtgcatg acgcgagggg gactgaacgg     1200

cgcggtgcgg catgcttcac ttggacagct gctcttgtgg gtcaggcaga gagagactcc     1260

ctcgaggaag gatttgtagg gtgaaggact ttgggagcat cgagaattct ttctgcccaa     1320

ctaagcgaat tatagcgaac tgcggaaagg tgaggctccg ggagaggaag cgcccatctc     1380

tggactccca tccatcccta tcctgtcctt tcccccttcc cagacaacag gagaacccgt     1440

gaattgtgta aataaaattc tgctttttct attctgaaaa aggacttacc taggaccatg     1500

gcaaataatc tctaacaatt tacctggaaa ttaaggaatt gggggtattt tgttctggca     1560

acaggaaatt tacccttctg ctgaaatcca agatattcag tgctctgcag aagcctctcc     1620

ccctcacaga tctctgcggc tgctgattgg taaaggaagc ttgaggaggg aactgcagcc     1680

ctaggaatct gggtgaatgg ggttccaagg gcccctgggc tgggaggagc tggctatgaa     1740

tgtgcatgaa gacataatag ctcaacctct aggattttgc atgcagagcg gatcctgcct     1800

tgtcactgac ttcatctggg attgcttttc cactccctgg ggcttagaga acaaagagcc     1860

cggttcacag gcagagactc gggggtgctc agcagcagcc cagatttagg ggacatttga     1920

gggactcttg gggccgcagc caaaaactgt ctctcctggc tacacctgct taacttcagt     1980

tcctttttct gtcaatatgt ccttgcccac tgcctctcgg tgttgccttc ataatgtctt     2040

gtgtgtgtta tgtgtgtcta cttgtgtagt agtgtgtgag ccctcagggg cagggcttgt     2100

ggctctggtg ttaggttcag gggcttcaga cccttctacg agctccaagc tatcaatggc     2160

gcttttctct ccctcttccc ccaaccaggg catggagcat gtggctgtcc tgaggttctt     2220

ttactgatgt gccgcccttc cacctcctca agtggtgact ttgtgtgccc tccccctcct     2280

ttgtgtattc cttctcaatg ctttccttgg tgttaacctt aataaaaagg cgtcatctcc     2340

cctc                                                                  2344


<210> 865
<211> 4619
<212> DNA
<213> Homo sapiens

<400> 865
gtccaacgcc agcaggcttc cgggcccgga gtgggcggtg ggactcgggg tcccagagag       60

ccgtgcgcgg gccgcgacgc cgagcaccgc cctcgccgtc gcctccgggc tttctccggt      120

cgctgccgcc accaccgttg cttcgcgggc tgggaggccc ggggtccccg ggcgaacaga      180

ggctgcgggt gggagccttc gcgggcgctg cagagcgggc cgggggaggc cgggatggag      240

ccccgcggag tggactgacg ccgcaggggc gagctagccg gctccgcgcc tctccgcggg      300

atccagacgc ctcctggggc tgctggcgga gggtctgagg cggcgcggcc atggctcacc      360

tccggggatt tgccaaccag cactctcgag tggaccctga ggagctcttc accaagctcg      420

accgcattgg caagggctcg tttggggagg tctacaaggg catcgataac cacacaaagg      480

aggtggtggc catcaagatc atcgacctgg aggaggccga ggatgagatc gaggacatcc      540

agcaggagat cactgtcctc agtcagtgcg acagccccta catcacccgc tactttggct      600

cctacctaaa gagcaccaag ctatggatca tcatggagta cctgggcggc ggctcagcac      660

tggacttgct taaaccaggt cccctggagg agacatacat tgccacgatc ctgcgggaga      720

ttctgaaggg cctggattat ctgcactccg aacgcaagat ccaccgagac atcaaagctg      780

ccaacgtgct actctcggag cagggtgacg tgaagctggc ggactttggg gtagcagggc      840

agctcacaga cacgcagatt aagaggaaca cattcgtggg cacccccttc tggatggcac      900

ctgaggtcat caagcagtcg gcctacgact tcaaggctga catctggtcc ctggggatca      960

cagccatcga gctggccaag ggggagcctc caaactctga cctccacccc atgcgcgtcc     1020

tgttcctgat tcccaagaac agcccaccca cactggaggg ccagcacagc aagcccttca     1080

aggagttcgt ggaggcctgc ctcaacaaag acccccgatt ccggcccacg gccaaggagc     1140

tcctgaagca caagttcatc acacgctaca ccaagaagac ctccttcctc acggagctca     1200

tcgaccgcta taagcgctgg aagtcagagg ggcatggcga ggagtccagc tctgaggact     1260

ctgacattga tggcgaggcg gaggacgggg agcagggccc catctggacg ttccccccta     1320

ccatccggcc gagtccacac agcaagcttc acaaggggac ggccctgcac agttcacaga     1380

agcctgcgga gcccgtcaag aggcagccga ggtcccagtg cctgtccacg ctggtccggc     1440

ccgtcttcgg agagctcaaa gagaagcaca agcagagcgg cgggagcgtg ggtgcgctgg     1500

aggagctgga gaacgccttc agcctggccg aggagtcctg ccccggcatc tcagacaagc     1560

tgatggtgca cctggtggag cgagtgcaga ggttttcaca caacagaaac cacctgacat     1620

ccacccgctg aagcgcactg ctgttcagat aggggacgga aggtcgtttg tttttgttct     1680

gagctccata agaactgtgc tgacttggaa ggtgccctgt gctatgtcgt gcctgcaggg     1740

acacgtcgga tcccgtgggc ctcacatgcc aggtcaccag gtcaccgtct ccttccaccc     1800

ctgcagtgtg ctgttgtgca cgtcagggac gctgttctct atgcccactg ccctcctccc     1860

tctcctggcc cagcagtatt gctcacgggg gctccagccg ccggcgtggc cctcatgagc     1920

tacgcctggg tcttctgcag actcatgcag ccctatggcc gctcagacca aggcgcagag     1980

caactatcag ggcagctctg cctcctcctc ccatgaggtg gggagaggca acagggcagc     2040

ccccagagga gtgtcctggc cgctgtcctc ccggggccca tgatggccat agatttgcct     2100

tgtggtgttg gatcaggtac tgtgtctgct cataagtact tgtgtcatcc agaatgtttt     2160

gttttttaag aaaattgaat tacttgtttc ctgaaatatt ctgaggttaa tatgttagtt     2220

ttcatagaac attgagaggc ccctgccact ttcaataaag acctgacttg gagacatgca     2280

ggtgtgtgtg gtggggcccg ggccatgcgg ggctgcagcg tccctggtcc cgagtcctca     2340

tcacagcacg cagagacggc agcccagccc cccttcgaaa cttccctgtg acggattcct     2400

gggctctgct tggcccaccg gaagaacaga gcaggcagag gagaatgcag gtggggagat     2460

gctgtttgtt tatttttaat caaatgtgtg tgaacaaagc agtcgcccat ctacttcccg     2520

ttggaaggaa tgctgggcag taataaatta gacggcccca ccctcccagg gcacaggggg     2580

actttggttt ctgcttctct agaggtacat ggggaacaag cgtggcttct gccagacttg     2640

tttagctgtg acctgcaggg caggcccctg gggctgccac ttggttcacc agatggaagg     2700

tcagcatggc tgtgccacgc ttgtctgaga gggtcctggc agtgggtacg cagggtgtat     2760

ggcagggcct cttttccagt gcttgctcta ggccagtcct cggcagggac cctgctctgg     2820

ggagagaggc agggtgtgcc caggctttgg tccgatgccg agagcactgc tcaggccttg     2880

tctgcgtctt tgagccaggg gcctgggagc tgtggcttga gcggctccgc gctcaagact     2940

cgcacatttt tcccagggcc ccagatagct gctggcatgc actaggtcct gggtgggggg     3000

atgaagcccc tcccagatgt tacatgaggc ccacccacac tgctggtgcc agtggggatc     3060

cagtgagacc acagccactt cccatctgtt gagaagcctc aggacagagg tcacctctgt     3120

gtcctgctgt tctttgtagt tgtgtccaaa cctgggcagg ttgagcgtca ttcctccttc     3180

cccctgacca tcccctccag ccctgaggag ggttgggggc catcctgcac gatgcttggg     3240

gccctcccgg ctgagctgct ggccccctgg atcacctcca tccacctgga ggagagggcg     3300

gccatcagac cagtgagcca tcttgtgctc agacactgtc ccaagaacaa cccaggatat     3360

gggacaagca ggacaaaaga agggttaaaa acctggggcc gggtgcggtg gctcatgcct     3420

ataatcccag cactttggga ggctgaggca gatggatcac ttgaggtcag gagttcgaga     3480

ccagcctggc caacatggtg aaaccctgtc tctactaaaa atacaaaaat tagccaggcg     3540

gcgtggcgtg catgcctgta atctcagtta ctcaggaggc tgaggcagaa gaatcgcttg     3600

aaccctggag gtgcaggtta tagtgagcca agattgtatc actgcactcc agcctgagtg     3660

acagagggag acgccatctc caaaaaaaaa aaaaacaaag cattgctgtt ttttggaaat     3720

gctggaagca ttgctcagcc cttcctttcc agggcccaga aaacttgcct ccaccaccat     3780

gagtagaaat gggagctgag cggacatcga aatgggcagc tgaccagggc tgcctcctgc     3840

aaaattacct ttcaaatgtg tacttgctct cagcccggaa gaagtagacg tgggatttga     3900

actggagctt gaaaacatag tctttgtgta tgccatcggc ctccctgggg atgctcacgc     3960

tgtagcccag cagcgggagg ctggccagtg ggtagtcatc ctgcaagaca gcatagggac     4020

acgggttcca ggggctgggt tgccacaggg aatgcccatt cctctgctac ctgcacaacg     4080

gtggcacgta caaatgccca cgggccaagg gagccagttt ccctgttcac acagcacagg     4140

gtgtgtgggc aaagcatggg agggcagaac caaaatacaa aagggacaca ggtgagcagg     4200

gttaagtgtc tgtctgctag catcacctgc attgggctcc agtgaaactc cagtacctga     4260

tgagttttgt agaagaacaa acagaagttg gtaaagacga cccagagctt ctgccagcca     4320

tgactgtttt tgaactttct tagcagatat cctgaaagct ggttctgtca ataaaggaaa     4380

aatgcaggtg cattaaccag cacccaggac cccttgtggg agtgggtttg ctccccaaga     4440

ctaagcctct gcatgctttc tccagctgag gccttggttt tacctctgga ctgctatgaa     4500

cagcagcttt atcagtactt aagtccaaca gaagcatgtt aaaaacctag agtgacattc     4560

caggcaccaa gtaaagtgag ttccctttcc ctgtgcacaa taaagtcagt gttcagtaa      4619


<210> 866
<211> 2223
<212> DNA
<213> Homo sapiens

<400> 866
ggaaaattac ccggtatcgt tagagctaca ccaaaattgc attgagccaa acttgccacc       60

aagagcccaa caatcaccat gatgctgagc acggaaggca gggaggggtt cgtggtgaag      120

gtcaggggcc taccctggtc ctgctcagcc gatgaagtga tgcgcttctt ctctgattgc      180

aagatccaaa atggcacatc aggtattcgt ttcatctaca ccagagaagg cagaccaagt      240

ggtgaagcat ttgttgaact tgaatctgaa gaggaagtga aattggcttt gaagaaggac      300

agagaaacca tgggacacag atacgttgaa gtattcaagt ctaacagtgt tgaaatggat      360

tgggtgttga agcatacagg tccgaatagc cctgatactg ccaacgatgg cttcgtccgg      420

cttagaggac tcccatttgg ctgtagcaag gaagagattg ttcagttctt ttcagggttg      480

gaaattgtgc caaatgggat gacactgcca gtggactttc aggggcgaag cacaggggaa      540

gcctttgtgc agtttgcttc acaggagata gctgagaagg ccttaaagaa acacaaggaa      600

agaatagggc acaggtacat tgagatcttc aagagtagcc gagctgaagt tcgaacccac      660

tatgatcccc ctcgaaagct catggctatg cagcggccag gtccctatga taggccgggg      720

gctggcagag ggtataatag cattggcaga ggagctgggt ttgaaaggat gaggcgtggt      780

gcctatggtg gagggtatgg aggctatgat gactatggtg gctataatga tggatatggc      840

tttgggtctg atagatttgg aagagacctc aattactgtt tttcaggaat gtctgatcat      900

agatacggag atggtgggtc cagtttccag agcaccacag ggcactgtgt acacatgagg      960

gggttacctt acagagccac tgagaatgat atttataatt tcttctcacc tcttaatccc     1020

atgagagtac atattgaaat tggacccgat ggcagagtta ccggtgaggc agatgttgaa     1080

tttgctactc atgaagatgc tgtggcagct atggcaaaag acaaagctaa tatgcaacac     1140

agatatgtgg agctcttctt aaattctact gcaggaacaa gtgggggtgc ttacgatcac     1200

agctatgtag aacttttttt gaattctaca gcaggggcaa gtggtggcgc ttatggtagc     1260

caaatgatgg gagggatggg cttatccaac cagtctagtt atggaggtcc tgctagccag     1320

cagctgagtg gtggttatgg aggtggttat ggtggtcaga gcagtatgag tggatatgac     1380

caagttctgc aggaaaactc cagtgactat cagtcaaacc ttgcttaggt agagaaggag     1440

cactaaatag ctactccaga tataaaagct gtacatttgt gggagttgaa tagaatggga     1500

gggatgttta gtatatccag tatgattggt aaatgggaaa tataattgat tctgatcact     1560

cttggtcagc ttctctttct ttatctttct ttctcctttt ttaagaaaac gagttaagtt     1620

taacagtttt gcattacagg cttgtgattc atgcttactg taaagtggaa gttgagatta     1680

ttttaaaact tcaagctcag taattttgaa cactgaaaca ttcatctagg acataataac     1740

aaagttcagt attgaccata actgttaaaa caatttttag ctttcctcaa gttagttatg     1800

ttgtaggagt gtacctaagc agtaagcgta tttaggttaa tgcagtttca cttatgttaa     1860

atgttgctct tataccacaa atacattgaa aacttcggat gcatgttgag aaacatgcct     1920

ttctgtaaaa ctcaaatata ggagctgtgt ctacgattca aagtgaaaac atttggcatg     1980

tttgttaatt ctagcttttt ggtttaatat cctgtaaggc acgtgagtgt acactttttt     2040

tttttttaag gatacgggac aattttaaga tgtaatacca atactttaga agtttggtcg     2100

tgtcgtttgt atgaaaatct gaggctttgg tttaaatctt tccttgtatt gtgatttcca     2160

tttagatgta ttgtactaag tgaaacttgt taaataaatc ttccttttaa aaactggaaa     2220

aaa                                                                   2223


<210> 867
<211> 1468
<212> DNA
<213> Homo sapiens

<400> 867
aagatggcgg ctgccgcgga gtgcgatgtg gtaatggcgg cgaccgagcc ggagctgctc       60

gacgaccaag aggcgaagag atatgtgtcc taaaaatgct agctattatg gtaatcgagc      120

agccaccttg atgatgcttg gaaggttccg ggaagctctt ggagatgcac aacagtcagt      180

gaggttggat gacagttttg tccggggaca tctacgagag ggcaagtgcc acctctctct      240

ggggaatgcc atggcagcat gtcgcagctt ccagagagcc ctagaactgg atcataaaaa      300

tgctcaggca caacaagagt tcaagaatgc taatgcagtc atggaatatg agaaaatagc      360

agaaacagat tttgagaagc gagattttcg gaaggttgtt ttctgcatgg accgtgccct      420

agaatttgcc cctgcctgcc atcgcttcaa aatcctcaag gcagaatgtt tagcaatgct      480

gggtcgttat ccagaagcac agtctgtggc tagtgacatt ctacgaatgg attccaccaa      540

tgcagatgct ctgtatgtac gaggtctttg cctttattac gaagattgta ttgagaaggc      600

agttcagttt ttcgtacagg ctctcaggat ggctcctgac cacgagaagg cctgcattgc      660

ctgcagaaat gccaaagcac tcaaagcaaa gaaagaagat gggaataaag catttaagga      720

aggaaattac aaactagcat atgaactgta cacagaagcc ctggggatag accccaacaa      780

tataaaaaca aatgctaaac tctactgtaa tcggggtacg gttaattcca agcttaggaa      840

actagatgat gcaatagaag actgcacaaa tgcagtgaag cttgatgaca cttacataaa      900

agcctacttg agaagagctc agtgttacat ggacacagaa cagtatgaag aagcagtacg      960

agactatgaa aaagtatacc agacagagaa aacaaaagaa cacaaacagc tcctaaaaaa     1020

tgcgcagctg gaactgaaga agagtaagag gaaagattac tacaagattc taggagtgga     1080

caagaatgcc tctgaggacg agatcaagaa agcttatcgg aaacgggcct tgatgcacca     1140

tccagatcgg catagtggag ccagtgctga ggttcagaag gaggaggaga agaagttcaa     1200

ggaagttgga gaggccttta ctatcctctc tgatcccaag aaaaagactc gctatgacag     1260

tggacaggac ctagatgagg agggcatgaa tatgggtgat tttgatccaa acaatatctt     1320

caaggcattc tttggcggtc ctggcggctt cagctttgaa gcatctggtc cagggaattt     1380

cttttttcaa tttggctaat gaagggcaac cacccagaac ccagaaaatg cagattcact     1440

cagtttaatc ttgaatgtgg aaacagtt                                        1468


<210> 868
<211> 1948
<212> DNA
<213> Homo sapiens

<400> 868
agggaagttc tcactggaca aaagcgtggt ctctggcgcg gggatctcag agtttcccgg       60

gcactcaccg tgtgtagttg gcatctccgc gcgtccggac acccgatccc agcatccctg      120

cctgcaggac tgttcgtgtt cagctcgcgt cctgcagctg tccgaggtgc tccagttgga      180

ggctgaggtt cccgggctct gtagctgagt gggcggcggc accggcggag atgcctggga      240

agaaggcgcg caagaacgct caaccgagcc ccgcgcgggc tccagcagag ctggaagtcg      300

agtgtgctac tcaactcagg agatttggag acaaactgaa cttccggcag aaacttctga      360

atctgatatc caaactcttc tgctcaggaa cctgactgca tcaaaaactt gcatgagggg      420

actccttcaa aagagttttc tcaggaggtg cacgtttcat caatttgaag aaagactgca      480

ttgtaattga gaggaatgtg aaggtgcatt catgggtgcc cttggaaacg gaagatggaa      540

tacatcaaag tgaatttctg ttcaagtttt cccagattat cattctttgg gatgagagaa      600

cattataaaa ccactttgtt tattttaaag caagaatgga agacccttga aaataaagaa      660

gtaattattg acacatttct tttttactta gagaatcgtt ctagtgtttt tgccgaagat      720

taccgctggc ctactgtgaa gggagatgac ctgtgattag actgggcggc tggggagaaa      780

cagttcagtg cattgttgtt gttgctgttt ttggtgtttt gcttttcagt gccaactcag      840

cacattgtat atgattcggt ttatacatat taccttgtta taatgaaaaa actcattctg      900

agaacactga aatgttatac tcagtgttga tttcttcggt cactacacaa cgtaaaatca      960

tttgtttctt ttgactcaaa ttgtattgct tctgttcaga tgatctttca ttcaatgtgt     1020

tcctgttggg cgttactaga aactatggaa aactggaaaa taactttgaa aaaattggat     1080

aaagtatagg agggttactt ggggccagta aatcagtaga ctgaacattc aatataataa     1140

aagaacatgg ggattttgta taaccaggga taataaaaag aaaaaagaag ttaattttta     1200

attgatgttt ttgaaactta gtagaacaaa tattcagaag taacttgata agatatgaat     1260

gtttctaaag aagtttctaa aggttcggaa aatgctcctt gtcacattag tgtgcatcct     1320

acaaaaagtg atctcttaat gtaaattaag aatattttca taattggaat atacttttct     1380

taaaaaaaag gaacagttag ttctcatcta gaatgaaagt tccatatatg cattggtgaa     1440

tatatatgta tacacatact tacatactta tatgggtatc tgtatagata atttgtatta     1500

gagtattata tagcttctta gtagggtctc aagtaagttt catttttttt atctgggcta     1560

tatacagtcc tcaaataaat aatgtcttga ttttatttca gcaggaataa ttttatttat     1620

tttgcctatt tataattaaa gtatttttct ttagtttgaa aatgtgtatt aaagttacat     1680

ttttgagtta caagagtctt ataactactt gaatttttag ttaaaatgtc ttaatgtagg     1740

ttgtagtcac tttagatgga aaattacctc acatctgttt tcttcagtat tacttaagat     1800

tgtttattta gtggtagaga gttttttttt tcagcctaga ggcagctatt ttaccatctg     1860

gtatttatgg tctaatttgt atttaaacat atgcacacat ataaaagttg atactgtggc     1920

agtaaactat taaaagtttt cactgttc                                        1948


<210> 869
<211> 2112
<212> DNA
<213> Homo sapiens

<400> 869
gcagactgcc ataagatggc gtccgtggcg gctgcacgag cagttcccgt gggcagtggg       60

ctcaggggcc tgcaacggac cctacctctt gtagtgattc tcggggccac gggcaccggc      120

aaatccacgc tggcgttgca gctaggccag cggctcggcg gtgagatcgt cagcgctgac      180

tccatgcagg tctatgaagg cctagacatc atcaccaaca aggtttctgc ccaagagcag      240

agaatctgcc ggcaccacat gatcagcttt gtggatcctc ttgtgaccaa ttacacagtg      300

gtggacttca gaaatagagc aactgctctg attgaagata tatttgcccg agacaaaatt      360

cctattgttg tgggaggaac caattattac attgaatctc tgctctggaa agttcttgtc      420

aataccaagc cccaggagat gggcactgag aaagtgattg accgaaaagt ggagcttgaa      480

aaggaggatg gtcttgtact tcacaaacgc ctaagccagg tggacccaga aatggctgcc      540

aagctgcatc cacatgacaa acgcaaagtg gccaggagct tgcaagtttt tgaagaaaca      600

ggaatctctc atagtgaatt tctccatcgt caacatacgg aagaaggtgg tggtcccctt      660

ggaggtcctc tgaagttctc taacccttgc atcctttggc ttcatgctga ccaggcagtt      720

ctagatgagc gcttggataa gagggtggat gacatgcttg ctgctgggct cttggaggaa      780

ctaagagatt ttcacagacg ctataatcag aagaatgttt cggaaaatag ccaggactat      840

caacatggta tcttccaatc aattggcttc aaggaatttc acgagtacct gatcactgag      900

ggaaaatgca cactggagac tagtaaccag cttctaaaga aaggtattga ggctctgaaa      960

caagtaacta agagatatgc ccggaaacaa aaccgatggg ttaaaaaccg ttttttgagc     1020

agacctggtc ccattgtccc ccctgtctat ggcttagagg tatctgatgt ctcgaagtgg     1080

gaagagtctg ttcttgaacc tgctcttgaa atcgtgcaaa gtttcatcca gggccacaag     1140

cctacagcca ctccaataaa gatgccatac aatgaagctg agaacaagag aagttatcac     1200

ctgtgtgacc tctgtgatcg aatcatcatt ggggatcgcg aatgggcagc gcacataaaa     1260

tccaaatccc acttgaacca actgaagaaa agaagaagat tggactcaga tgctgtcaac     1320

accatagaaa gtcagagtgt ttccccagac cataacaaag aacctaaaga gaagggatcc     1380

ccagggcaga atgatcaaga gctgaaatgc agcgtttaag agacatgtcc agtggccttt     1440

ggaaaggtgg tggggatcca gttcaggagg gaggggtatg tttgtctccc agtctgggca     1500

aaggagtgct atgcggaatt ctctgcatag cagaaaagct cccaccattt tcttttgatg     1560

tggttttaaa gtctcacgtt ctctataata gaaacagcag gtcttgtcag ctccttgtgt     1620

ggctgatgtg tctggaaatg atgtagttca ggaaagcatt ttttttttct ttgaacctta     1680

aaggttctat tattaaaagc agcacagatt ccacattttt atacatgagg atcttctttg     1740

tggtgaatac caggattgac tgcatccctt taaagaagtt ttatgtccct gactctggct     1800

aaaattatct aatttccaga tgcttttgta gatgactgaa gtatttgtga gccacatatt     1860

gggagttcta gatttgagtg aatggcagga aagggccatc tccattgaga tgattaagtg     1920

aaccaaacta gttctcagaa ttctacagag aaggagggaa tcagactgag gaagctgtga     1980

cataggactt gaagaccaaa gactttgaaa tttgcgagct gctcatgtgt gagttattat     2040

cactgctgtc tttctattga gttacaaatc tatattttta ttgaagttta aataaagaaa     2100

aaatttacaa ga                                                         2112


<210> 870
<211> 839
<212> DNA
<213> Homo sapiens

<400> 870
atcccagaag ctgctgttag ctcgccggtc ctcggcacgc cgcccgttcg cccctgcgct       60

gtccgccctt cccctagcgt tacttccggt ccctcgctga gggggttcgt gcggctccca      120

ggaggcgtga accgcggacc atgagcgtgg gcttcatcgg ggccggccag ctggcctatg      180

ctctggcgcg gggcttcacg gccgcaggca tcctgtcggc tcacaagata atagccagct      240

ccccagaaat gaacctgccc acggtgtccg cgctcaggaa gatgggtgtg aacctgacac      300

gcagcaacaa ggagacggtg aagcacagcg acgtcctgtt tctggctgtg aagccacata      360

tcatcccctt catcctggat gagattgggg ccgacgtgca agccagacac atcgtggtct      420

cctgtgcggc tggtgtcacc atcagctctg tggagaagaa gctgatggca ttccagccag      480

cccccaaagt gattcgctgc atgaccaaca cacctgtggt agtgcaggaa ggcgctacag      540

tgtacgccac gggcacccat gccctggtgg aggatgggca gctcctggag cagctcatga      600

gcagcgtggg cttctgcact gaggtggaag aggacctcat cgatgccgtc acggggctca      660

gtggcagcgg gcctgcctat cagtccatgg ccgaccaaga aaagatctcc ccagctgccc      720

ttaagaagac cctcttagac agagtgaagc tggaatcccc cacagtctcc acactgaccc      780

cctccagccc agggaagctc ctcacaagaa gcctggccct gggaggcaag aaggactaa       839


<210> 871
<211> 999
<212> DNA
<213> Homo sapiens

<400> 871
gcggctccca ggaggcgtga accgcggacc atgagcgtgg gcttcatcgg ggccggccag       60

ctggccatgc tctggcgcgg ggcttcacgg ccgcagcatc ctgtcggctc acaagataat      120

agccagctcc ccagaaatga acctgcccac ggtgtccgcg ctcaggaaga tgggtgtgaa      180

cctgacacgc agcaacaagg agacggtgaa gcacagcgac gtcctgtttc tggctgtgaa      240

gcccatatca tccccttcat cctggatgag attggggccg acgtgcaagc cagacacatc      300

gtggtctcct gtgcggctgg tgtcaccatc agctctgtgg agaagaagct gatggcattc      360

cagccagccc ccaaagtgat tcgctgcatg accaacacac ctgtggtagt gcaggaaggc      420

gctacagtgt acgccacggg cacccatgcc ctggtggagg atgggcagct cctggagcag      480

ctcatgagca gcgtgggctt ctgcactgag gtggaagagg acctcatcga tgccgtcacg      540

gggctcagtg gcagcgggcc tgcctatgca ttcatggctc tggacgcatt ggctgatggt      600

ggggtgaaga tgggtttgcc acggcgcctg gcaatccaac tcggggccca ggctttgctg      660

ggagctgcca agatgctgct ggactcggag cagcatccat gccagcttaa ggacaatgtc      720

tgctcccctg ggggagccac catccacgcc ctgcactttc tagagagtgg gggcttccgc      780

tctctgctca tcaatgcagt tgaggcctcc tgtatccgaa cacgagagct acagtccatg      840

gccgaccaag aaaagatctc cccagctgcc cttaagaaga ccctcttaga cagagtgaag      900

ctggaatccc ccacagtctc cacactgacc ccctccagcc cagggaagct cctcacaaga      960

agcctggccc tgggaggcaa gaaggactaa ggcagcatc                             999


<210> 872
<211> 1536
<212> DNA
<213> Homo sapiens

<400> 872
ggaactcgcc gggccacacc ccctgtccag ggaaggaaca cgcccccggt gacagccggt       60

acggccccgg gtttgggcaa cctcgattac gggcggcctc cagccccgcc agcagcgccc      120

cgcgcccgcc cgcccgcgcc cctgccgccc cccggttccg gccgcggacc ccactctctg      180

ccgttccggc tgcggctccg ctgccggtag cgccgtcccc cgggaccacc cttcggctgg      240

cgccctccca tgctctcggc cacccggagg gcttgccagc tcctcctcct ccacagcctc      300

tttcccgtcc cgaggatggg caactcggcc tcgaacatcg tcagccccca ggaggccttg      360

ccgggccgga aggaacagac ccctgtagcg gccaaacatc atgtcaatgg caacagaaca      420

gtcgaacctt tcccagaggg aacacagatg gctgtatttg gaatgggatg tttctgggga      480

gctgaaagga aattctgggt cttgaaagga gtgtattcaa ctcaagttgg ttttgcagga      540

ggctatactt caaatcctac ttataaagaa gtctgctcag aaaaaactgg ccatgcagaa      600

gtcgtccgag tggtgtacca gccagaacac atgagttttg aggaactgct caaggtcttc      660

tgggagaatc acgacccgac ccaaggtatg cgccagggga acgaccatgg cactcagtac      720

cgctcggcca tctacccgac ctctgccaag caaatggagg cagccctgag ctccaaagag      780

aactaccaaa aggttctttc agagcacggc ttcggcccca tcactaccga catccgggag      840

ggacagactt tctactatgc ggaagactac caccagcagt acctgagcaa gaaccccaat      900

ggctactgcg gccttggggg caccggcgtg tcctgcccag tgggtattaa aaaataattt      960

ctccccacat ggtgggcctt tgaggttcca gtaaaaatgc tttcaacaaa ttgggcaatg     1020

cttgtgtgat tcacaatcgt ggcatttaaa gtgcacaaag tacaaaggaa tttatacaga     1080

ttgggtttac cgaagtataa tctataggag gcgcgatggc aagttgataa aatgtgactt     1140

atctcctaat aagttatggt gggagtggag ctgtgcagtt tcctgtgtct tctggggtct     1200

gagtgaagat agcagggatg ctgtgttcac ccttcttggt agaagctaag gtgtgagctg     1260

ggaggttgct ggacaggatg ggggacccca gaagtccttt atctgtgctc tctgcccgcc     1320

agtgccttac aatttgcaaa cgtgtatagc ctcagtgact cattcgctga aatccttcgc     1380

tttaccaaat ctagacatac ataaggggct ttctctccct tttcagccct ctctgtgcag     1440

agaaaagatg tgagtccgct tgatgaattc taatgctttg cttagagcta tgagaaatgt     1500

ttgttttaat aaaaacctac agtccaataa tgccaa                               1536


<210> 873
<211> 4688
<212> DNA
<213> Homo sapiens

<400> 873
attatgcaac ccgcctcccc gcccgcccgg tggagcttcc actcggctgc gggctggagc       60

ggcggcgggc aggcgtgcgg aggacactcc tgcgaccagg tactggctgt gatcgaactt      120

ctcaaccctc agagacttag atcttccacc tcactccctc agccaagcct ccaggccccc      180

tcgtgcatcc gtggtggcct ctctgccttc tctgttctgt tctccccatg gcccagacat      240

gagtggcccc ctagaagggg ctgatggggg aggggacccc aggcctgggg aatcattttg      300

tcctgggggc gtcccatccc ctgggccccc acagcaccgg ccttgcccag gccccagcct      360

ggccgatgac accgatgcca acagcaatgg ttcaagtggc aatgagtcca acgggcatga      420

gtctagaggc gcatctcagc ggagctcaca cagctcctcc tcaggcaacg gcaaggactc      480

agccctgctg gagaccactg agagcagcaa gagcacaaac tctcagagcc catccccacc      540

cagcagttcc attgcctaca gcctcctgag tgccagctca gagcaggaca acccgtccac      600

cagtggctgc agcagtgaac agtcagcccg ggcaaggact cagaaggaac tcatgacagc      660

acttcgagag ctcaagcttc gactgccgcc agagcgccgg ggcaagggcc gctctgggac      720

cctggccacg ctgcagtacg cactggcctg tgtcaagcag gtgcaggcca accaggaata      780

ctaccagcag tggagcctgg aggagggcga gccttgctcc atggacatgt ccacctatac      840

cctggaggag ctggagcaca tcacgtctga gtacacactt cagaaccagg ataccttctc      900

agtggctgtc tccttcctga cgggccgaat cgtctacatt tcggagcagg cagccgtcct      960

gctgcgttgc aagcgggacg tgttccgggg tacccgcttc tctgagctcc tggctcccca     1020

ggatgtggga gtcttctatg gttccactgc tccatctcgc ctgcccacct ggggcacagg     1080

ggcctcagca ggttcaggcc tcagggactt tacccaggag aagtccgtct tctgccgtat     1140

cagaggaggt cctgaccggg atccagggcc tcggtaccag ccattccgcc taaccccgta     1200

tgtgaccaag atccgggtct cagatggggc ccctgcacag ccgtgctgcc tgctgattgc     1260

agagcgcatc cattcgggtt acgaagctcc ccggataccc cctgacaaga ggattttcac     1320

tacgcggcac acacccagct gcctcttcca ggatgtggat gaaagggctg cccccctgct     1380

gggctacctg ccccaggacc tcctgggggc cccagtgctc ctgttcctgc atcctgagga     1440

ccgacccctc atgctggcta tccacaagaa gattctgcag ttggcgggcc agccctttga     1500

ccactcccct atccgcttct gtgcccgcaa cggggagtat gtcaccatgg acaccagctg     1560

ggctggcttt gtgcacccct ggagccgcaa ggtagccttc gtgttgggcc gccacaaagt     1620

acgcacggcc cccctgaatg aggacgtgtt cactcccccg gcccccagcc cagctccctc     1680

cctggacact gatatccagg agctgtcaga gcagatccac cggctgctgc tgcagcccgt     1740

ccacagcccc agccccacgg gactctgtgg agtcggcgcc gtgacatccc caggccctct     1800

ccacagccct gggtcctcca gtgatagcaa cgggggtgat gcagaggggc ctgggcctcc     1860

tgcgccagtg actttccagc agatctgtaa ggatgtgcat ctggtgaagc accagggcca     1920

gcagcttttt attgagtctc gggcccggcc tcagtcccgg ccccgcctcc ctgctacagg     1980

cacgttcaag gccaaggccc ttccctgcca atccccagac ccagagctgg aggcgggttc     2040

tgctcccgtc caggccccac tagccttggt ccctgaggag gccgagagga aagaagcctc     2100

cagctgctcc taccagcaga tcaactgcct ggacagcatc ctcaggtacc tggagagctg     2160

caacctcccc agcaccacta agcgtaaatg tgcctcctcc tcctcctata ccacctcctc     2220

agcctctgac gacgacaggc agaggacagg tccagtctct gtggggacca agaaagatcc     2280

gccgtcagca gcgctgtctg gggagggggc caccccacgg aaggagccag tggtgggagg     2340

caccctgagc ccgctcgccc tggccaataa ggcggagagt gtggtgtccg tcaccagtca     2400

gtgtagcttc agctccacca tcgtccatgt gggagacaag aagcccccgg agtcggacat     2460

catcatgatg gaggacctgc ctggcctagc cccaggccca gcccccagcc cagcccccag     2520

ccccacagta gcccctgacc cagccccaga cgcctaccgt ccagtggggc tgaccaaggc     2580

cgtgctgtcc ctgcacacac agaaggaaga gcaagccttc ctcagccgct tccgagacct     2640

gggcaggctg cgtggactcg acagctcttc cacagctccc tcagcccttg gcgagcgagg     2700

ctgccaccac ggccccgcac ccccaagccg ccgacaccac tgccgatcca aagccaagcg     2760

ctcacgccac caccagaacc ctcgggctga agcgccctgc tatgtctcac acccctcacc     2820

cgtgccaccc tccaccccct ggcccacccc accagccact acccccttcc cagcggttgt     2880

ccagccctac cctctcccag tgttctctcc tcgaggaggc ccccagcctc ttccccctgc     2940

tcccacatct gtgcccccag ctgctttccc cgcccctttg gtgaccccaa tggtggcctt     3000

ggtgctccct aactatctgt tcccaacccc atccagctat ccttatgggg cactccagac     3060

ccctgctgaa gggcctccca ctcctgcctc gcactcccct tctccatcct tgcccgccct     3120

cgccccgagt cctcctcacc gcccggactc tccactgttc aactcgagat gcagctctcc     3180

actccagctc aatctgctgc agctggagga gctcccccgt gctgaggggg ctgctgttgc     3240

aggaggccct gggagcagtg ccgggccccc acctcccagt gcggaggctg ctgagccaga     3300

ggccagactg gcggaggtca ctgagtcctc caatcaggac gcactttccg gctccagtga     3360

cctgctcgaa cttctgctgc aagaggactc gcgctccggc acaggctccg cagcctcggg     3420

ctccttgggc tctggcttgg gctctgggtc tggttcaggc tcccatgaag ggggcagcac     3480

ctcagccagc atcactcgca gcagccagag cagccacaca agcaaatact ttggcagcat     3540

cgactcttcc gaggctgagg ctggggctgc tcggggcggg gctgagcctg gggaccaggt     3600

gattaagtac gtgctccagg atcccatttg gctgctcatg gccaatgctg accagcgcgt     3660

catgatgacc taccaggtgc cctccaggga catgacctct gtgctgaagc aggatcggga     3720

gcggctccga gccatgcaga agcagcagcc tcggttttct gaggaccagc ggcgggaact     3780

gggtgctgtg cactcctggg tccggaaggg ccaactgcct cgggctcttg atgtgatggc     3840

ctgtgtggac tgtgggagca gcacccaaga tcctggtcac cctgatgacc cactcttctc     3900

agagctggat ggactggggc tggagcccat ggaagagggt ggaggcgagc agggcagcag     3960

cggtggcggc agtggtgagg gagagggctg cgaggaggcc caaggcgggg ccaaggcttc     4020

aagctctcag gacttggcta tggaggagga ggaagaaggc aggagctcat ccagtccagc     4080

cttacctaca gcaggaaact gcaccagcta gactccattc tgggaccatc tccaggagtc     4140

catgagaggc tttcttctcc tatgtcccaa ttctcagaac tcagatgtgg ctagaccaac     4200

cagtgggaaa ctgccccagc ttctcccacc atagggggcc ggacccccat caccagccta     4260

ggatccaggg gctgcctctg gcctcttagg gagcagagag cagaactccg cagcccagcc     4320

cagaggagtg tcacctccca cctttggaga ggaatccttc cctcccctgg acaaagttgc     4380

tgacaagctg ctgaagtggc ctctccatat tccagctgag cctgaatctg actcttgagg     4440

gttggggctg cacttattta ttgcggggag acagctctct ctcccacctc ctccccagat     4500

gggaggagag cctgaggccc aagcaggacc cgggggttcc agcccctagc tgctctggag     4560

tgggggaggt tggtggacca tggagtccct ggtgctgccc ctcaggtggg acccaggcgt     4620

tctcagctgt accctctgcc gatggcattt gtgtttttga tatttgtgtc tgttactact     4680

tttttaat                                                              4688


<210> 874
<211> 2381
<212> DNA
<213> Homo sapiens

<400> 874
gaagccacta gccggttact agctgcgctt ttgttccact tgagcgggca ctcttctgcg       60

gcaagcaggt ctaggaattc gcctggttcc cacctcgcgt cccttgcctt ccttcctagt      120

ctacccactg tagtgccccc tgcgtcccgc tccctcctag ccgactcaga gcacaagaag      180

gattgccacg gtttccattg cagcagccgt ggcgcctctg accctttttt tatatcgcgg      240

cgacggcggg ctgtcgtcac gacgacgtgc ggacgcagcg gcgggggcct ttcagcttat      300

gtggagaagt cgctgtgaag ccacctataa atccatttac tgaatttatg gagaaggctg      360

taaatgatgg aagtcattca gaagaactct tttgccatct taaaactata tcagagaaag      420

aagatttacc acggtgtacc agtgaaagtc atctcagctg cctgaagcag gacattctaa      480

atgaaaagac tgaattggaa gcaacactta aggaagcgga gttggtaact cattctgtag      540

aattgctttt gccactattt aaggacacca ttgaaaagat taattttgaa aatgcgaatc      600

tttctgcatt gaatttgaag atttctgaac agaaggaaat attaataaaa gaattagaca      660

ccttcaaaag tgtaaaacta gctttagaac atcttcttag aaagagagac tacaaacaaa      720

caggagacaa tttatccagc atgttgctag aaaatctaac tgataatgaa agtgaaaata      780

ctaatcttaa gaagaaggta tttgaaaagg aggcccatat ccaagaactt tcttgtttgt      840

ttcagagtga aaaggcaaat actttgaaag caaaccgttt ttcccaatca gtaaaagtag      900

tacatgaacg actacagatc caaattcata aaagggaagc cgagaacgat aagttgaaag      960

aatatgtaaa gagcttagaa accaagatag ccaagtggaa cctgcaatca agaatgaata     1020

agaatgaggc tatagtgatg aaagaagcaa gtaggcaaaa aactgtagct ttaaaaaagg     1080

catctaaagt ttacaaacaa aggcttgacc attttacagg agctattgaa aagcttactt     1140

cccaaattag agatcaggaa gccaagttgt ctgaaacaat ttcagcttcc aatgcctgga     1200

aaagtcatta tgagaaaatt gtgatagaaa aaaccgaatt ggaagtacag attgaaacaa     1260

tgaaaaagca aatcattaat cttttggaag atctgaagaa aatggaagac catggaaaaa     1320

attcatgtga agaaattctt agaaaagttc actcaattga atatgaaaat gaaactctga     1380

atcttgagaa tacaaaatta aagcttagat tcccatgtag aattactgag tcaaagaata     1440

tgaacatttt gattgttctt gatatgcttt gctacatttc ttctgaaaag actacacttg     1500

ctgctttgaa ggatgaagtt gtatctgttg aaaatgaact ctcagaattg caagaagtag     1560

aaaaaaaaca gaaaaccctt attgaaatgt ataaaactca ggtacaaaag ttgcaagaag     1620

cagctgaaat agtaaaaagc agatgtgaaa atttgctaca taaaaataac caaataacaa     1680

aaaccaaaaa taaaaatgta gagaagatga gaggccagat ggagtctcat ctgaaggagt     1740

tagagcgtgt ctgcgattcc ttgacggcgg cggaacggag gcttcacgag tgtcaggaga     1800

gtctgcagtg ctgcaagggg aagtgtgcag accaggaaca caccattagg gagcttcagg     1860

gccaggttga tggaaatcac aatcttctga caaagctttc tctggaagag gaaaactgtc     1920

ttattcagct gaagtgtgaa aaccttcaac aaaaattaga acagatggac gcagaaaata     1980

aagagcttga gaagaagctg gcaaaccaag aagaatgtct taagcacagc aatcttaagt     2040

ttaaagagaa atctgcagag tatacagcat tggccagaca actggaagct gctttagaag     2100

aaggaagaca aaaggttgct gaagaaatag agaaaatgtc atctagagag agtgctttac     2160

aaattaaaat attagatctg gaaactgagc ttagaaagaa aaatgaagaa caaaatcaac     2220

ttgtttgcaa aatgaacagt aaagcacaac atcaggaagt gtgtttgaaa gaagtacaaa     2280

atagtcttga gaagtcggaa aatcaaaatg agagtattaa gaattattta cagtttctta     2340

aaacttctta tgtaacaatg tttgaataaa ttgtcaaatt t                         2381


<210> 875
<211> 2186
<212> DNA
<213> Homo sapiens

<400> 875
ggtttgggag gcccaggcgg cggagcctcc gggacggcga gcggcgggcg gcggaggagg       60

agacggcagg tcgggcatta aaaaatattt aatcattcat gtgttgagac tcattcttga      120

gttatggatg acaaggcttc tgttggaaaa atcagtgtct cttcagactc agtatctact      180

cttaatagtg aagattttgt cttggtttcc aggcaaggag atgagacacc atctacaaat      240

aatggaagtg atgatgagaa aacaggactc aagattgtag ggaatggaag tgaacagcag      300

ctgcaaaaag agctagcaga tgtactgatg gatcctccaa tggacgacca gccaggggaa      360

aaggagcttg tgaaaaggtc acaactggat ggtgaaggag atgggcctct ttctaatcag      420

ctctccgctt catccaccat taaccctgtg ccattagtag ggctccaaaa accagagatg      480

agcctaccag tgaaacctgg acaaggagat tctgaagctt caagtccttt cacaccagtg      540

gccgatgagg acagcgtagt tttcagtaaa ctgacttact taggctgtgc ctcggtaaat      600

gctcccagga gtgaagtgga agccttaagg atgatgtcca tcttaagaag ccagtgtcag      660

atttcactag atgttaccct ttcagtgccg aatgtgtctg aaggaattgt gagactctta      720

gatcctcaga caaacactga aatagcaaac taccctatct acaaaatcct cttctgtgtc      780

agagggcatg atggaactcc tgagagtgac tgttttgctt tcactgaaag tcattacaat      840

gcagagctct tcagaataca cgtcttccgg tgtgaaatac aagaagctgt aagtcctcaa      900

gagaaaactc tctgcaaatg aaacttcacc agtgccctca ctaggttgaa atgattatgg      960

tatttattat gatcactcat aagccagatg aaattctctg ctattgtttt agtgattcta     1020

gcctcatggg ccaaaatata aattaactaa aaatttgatt aactagaact ttgttactac     1080

tactaagaat gtcagaggag atctgttggc tacttttgat tgggttaagt aggcattctg     1140

gttctaacat tgacagattt gcaaaccatt cttttaaatc aaaacttgtt aggactgttt     1200

tcattgtaat atcttcagat agtttctaac aatttaggaa gtgattttta aattggattt     1260

atagtgctta caaccatttc ttttttaaaa ccccttgtct ggacattttt agtgttgctt     1320

gctttatagg cctaacaaat taggtaattt accaaaagaa ataagtggga taaagataat     1380

tattgccctc caaagtaggt aatcttccag ccttaataaa ggtattttat atcttttgat     1440

aacagcccat ttcctaacat gtctggttgt aggtaagccg gatactttac agttttgcca     1500

ctgccttccg ccgttctgcc aagcagaccc cactttcagc cactgctgca ccccagactc     1560

ctgacagtga catctttacc ttctctgtgt ctttagaaat aaaagaagat gatggtaaag     1620

gttattttag gtagggaatc ttattttatt catgtattaa catgctgtgg ttcaggggaa     1680

attctaggtc agattataac tttcatacca taaaatgatg gcttttaaag ggagggcttt     1740

taaaaaaaat ctggatgata aaggcatata aatacataaa tttaacagag gcaaagtttg     1800

aagaatttta aagcaattaa aaaaattgtc atattgggaa catgttgcta ccttctttta     1860

gtcagatacc aagtggctaa ctgctcacaa aaatatggcc aaaccgccag gcgctgtggc     1920

tcacacctgt aatcccagct ctttgggtgg ctgaggcgga cggatcacct gaggtcggga     1980

gttcgagatg agcctgacca acatggagaa accttgtctc tactaaaaat acaaaattag     2040

ccgggcgtgg tggtgggtgc ctgtaatccc agctacttgg gaggctgagg caggagaatc     2100

gcttgaaccc ggcaggcaga ggttgcagtg agccgagatc ctgccactgc actccagcct     2160

gggcaacgag aacgaaactc cgtctc                                          2186


<210> 876
<211> 1310
<212> DNA
<213> Homo sapiens

<400> 876
attagctgac atcaggaact gagccaggca gtgtggttgt gatgtcacta tctcacctca       60

cccccaccta agagattgtg gtggggaatc tcagacactc taaccctctg ggcccaagtc      120

acctttctat caggggaggg aggctgtgct ctcactggct tcttgttaga agttctgcct      180

gccctacagc ctgcactgag ggctctcatc actgcttctg agatcttaat gggggtcaac      240

gaagatgtgg gcttctctga gtttagacca tccatctgcc aaggaaaacc aagccctgag      300

actgatagag atgagagaag agaatggtaa tgtccccaag acagagcagg caggaagttt      360

gaagcctctg agggatacag gaaaatctaa cctcaaagag aagaaggcca acagcaagct      420

gaagcagatt gagaaggaat acactcagaa gcttgccaaa tcttcacaga tcatagcaga      480

acttcagaca accatttcct ctctgaaaga agagaacagc cagcagcagc ttgctgcaga      540

aaggcggctc caggatgtta gacaaaagtt tgaagatgag aagaagcagc tgattagaga      600

taatgaccaa gcaatcaagg ttttacaaga tgaattagaa aaccgttcta atcaggtgcg      660

atgtgcagag aaaaaattac aacacaaaga attggagtca caggaacaga taacttacat      720

acgacaagaa tatgaaacaa aattgaaagg attgatgcca gcatccctaa gacaagaact      780

tgaagacacc atttcctccc taaaatcaca ggttaatttt ctgcaaaaga gagcttccat      840

ccttcaggaa gaactgacta catatcaagg cagaaggtaa ctgcacgaga gaatgcaacg      900

gatgcaattt ccaggctgtg ctgtggactt cttccagcag gtttgaagat ttggatattg      960

taaactgtga gatcagtggc attttttaaa tccttaaatg taattaagat cataaaaaca     1020

tgcatcattc atacactagt ggggtggttt tatttgtgtc tgcctaagtt atttttttaa     1080

cattccttta tttccgattt tcatgtttgt gtgcatttga gtatgtgctg agaactgctt     1140

atattgggca aagtgatttc ctatgatatg ccttgttaat ccttttgcat agaattttac     1200

cagttgcgta cgatcaaaat cacgtttgta gtatcatatc aaaaattcta acctgtttac     1260

attgttttca tgttcatgtt cctatgttat taaaatatta ttttgtactt                1310


<210> 877
<211> 2615
<212> DNA
<213> Homo sapiens

<400> 877
gaacactcat cagtgcgcag gcgcccatct tagttggtct tctagtccgg taaacagagg       60

gcctgccccc gacagcttct gcttccgggt cacgccttga cagcggcttt caacccccac      120

ctcagcccag caattcggca gtttggagca tgtgaacacc ttgagccttg atgagttcca      180

gtatgtggta tattatgcag agcattcaga gcaaatactc tctctccgag cgcttaatcc      240

gaacaattgc tgccatccgt tccttcccac atgataatgt agaggacctc atcagagggg      300

gagcagatgt gaactgcact catggcacac tgaagccctt gcactgtgcc tgtatggtgt      360

cagatgctga ctgtgtggag ttacttctgg aaaaaggagc cgaggtgaat gccctggatg      420

ggtataaccg aacagccctc cactatgcag cagagaaaga tgaggcttgt gtggaggtcc      480

tattggagta tggtgcaaac cccaatgctt tggatggcaa cagagatacc ccacttcact      540

gggcagcctt taagaacaat gctgagtgtg tgcgggctct cctagagagc ggggcctctg      600

tcaatgccct ggattacaac aatgatacac cgctcagctg ggctgccatg aagggaaatc      660

ttgagagtgt cagcatcctt ctggattatg gcgcagaggt cagagtcatc aacctaatag      720

gccagacacc catctcccgc ctggtggctc tgctagtcag gggacttgga acagagaaag      780

aggactcttg ctttgagctc ctccacagag ctgttggaca ctttgaattg aggaaaaatg      840

gcaccatgcc acgagaggtg gccagagacc cgcagctatg tgaaaaactg actgttctgt      900

gctcagctcc aggaactcta aaaacactcg ctcgctatgc cgtgcgccgt agcctgggac      960

tccagtatct ccccgatgca gtgaagggcc ttccactgcc agcttctttg aaggaatacc     1020

tgttactttt agaatagccg gagaagatgt ttgcaccatc gtgcaggcag ctctgggtga     1080

ggttgtccct gcagtactcc ttgtcacaga aaacagaaaa acagttgttc ctgttgtgtg     1140

gtttatagat ttcgaagcaa catgtcacaa caataacctc catagcacct ccccttccca     1200

aaccaaacaa cccaacaaaa aaaatccctc acttttgttt tctgtttatt gcttacctgg     1260

ctttttatat tgcattttgc aaaagaagag gtctccctca atcctcccct ttagggaagg     1320

agtcaacagt gtaactaaat ttctctagga agatggaaag tacttaaata atgtgtgtgt     1380

ggttttcctt tggggacgtg gttaacggtc cagaagaatc ccttctagaa agcattttag     1440

gccagccatg gtggctcacg tctgtaatcc caggactttg ggaggctgag gcaggtggat     1500

cacctgaggt caggagttcg agcccagcct gaccaatatg atgaaacccc gtctctacta     1560

aaaatacaaa aattagctgg gcatggtggc atgcgcctgt aatcccagct actcaggagg     1620

ctgagacaga agaatcgctt gaacctgtga ggcagaggtt gcagtgagcc aagatcgcgc     1680

cattgcactc cagcctggac aacaagagca aaactgtctc aaaaaaaaaa aaaaaaaaaa     1740

aaaaccattt taattgatct gtgaaaaaac ttaagaaaat cacaatttca gctaacagca     1800

attgtgtccc aaagatgaag atactataac ctcaaatggt gcagatccag aactgggctg     1860

gatgacatcc ctactgtgcc atgtcctggg gcatttggaa gggactggac ctctttcccc     1920

tcatcaaagg aaacagcagt ctttgcctct ttctgttggt tgtgcccaag ggctacagta     1980

gctctgaaat aacaagagct ctgtaataac agtaataaat agctctgaaa taacagtcct     2040

aagaactcct aaagtcctga gaacttttct tgtaatgcag ctttttctct tcctgagaaa     2100

cagtgtgttc taatgggatt cccaggcagt tcctacacct acggtgtgtg ttccagcagg     2160

gaggagttat gggctgggct gccttttccc atgggtcttc attcccaatg gaaagttcac     2220

tctgcttagt ttggaattat ttttctttca gttgttctgg aacctttgct ttttattgat     2280

ttatacaata caattggtgg gagggtggac ttgggatggg agtgggaaaa gcatgtaaga     2340

gctccttttg tgatggtcca tctacccaaa agagatctgc tttagtgaac gatactcttt     2400

catttttcta aattagatca agttgttatt gattttagat gacttgtatg caaatttgaa     2460

aaactttttt ttttaaagct gattgggaac tacaaacaat gaatggaatc tactgacaca     2520

gctaattgga aaacagatgt cttcttctgt cctattgatg ctggtgttta aaaaacatca     2580

cttaaaaaaa aagaataaat agttctaaaa gcaag                                2615


<210> 878
<211> 2002
<212> DNA
<213> Homo sapiens

<400> 878
ctcccggcaa gggtcccccg actggcgccc gcgcgtcctc cctcggctgc tgcaggccgg       60

gccgcggcgt cgagcggggg cggcggggcg gggcccgcag ccattggcga gcggcggggc      120

gggggcgggg gcgcggaggg tcggccccgg gacgcgcgca gccggcccgc agttgccgct      180

gtcgtccgca gagccagttc ctagcgcaga gccgcgcccg ccatgaggga gatcgtgcac      240

atccaggcgg gccagtgcgg gaaccagatc ggcaccaagt tttgggaagt gatcagcgat      300

gagcacggca tcgacccggc cggaggctac gtgggagact cggcgctgca gctggagaga      360

atcaacgtct actacaatga gtcatcgtct cagaaatatg tgcccagggc cgccctggtg      420

gacttagagc caggcaccat ggacagcgtg cggtctgggc cttttgggca gcttttccgg      480

cctgacaact tcatctttgg ccagacgggt gcagggaaca actgggcgaa agggcactac      540

acggagggcg cggagctggt ggacgcagtg ctggacgtgg tgcggaagga gtgcgagcac      600

tgcgactgcc tgcagggctt ccagctcacg cactcgctgg gcggcggcac gggctcaggc      660

atgggcacgc tgctcatcag caagatccgt gaggagttcc cggaccgcat catgaacacc      720

ttcagcgtca tgccctcgcc caaggtgtcg gacacggtgg tggagcccta caatgccaca      780

ctgtcggtgc accagctggt ggagaataca gacgagacct actgcatcga caacgaggcg      840

ctctatgaca tctgcttccg cactctgaag ctgacaacgc ccacctacgg ggacctcaac      900

cacctggtgt ccgccaccat gagtggggtc accacctcgc tgcgcttccc gggccagctc      960

aatgctgacc tgcgcaagct ggcggtgaac atggtgccct tcccgcgcct gcacttcttc     1020

atgcctggct tcgcgccgct caccagccgc ggcagccagc agtaccgggc cctgaccgtg     1080

cccgagctca cccagcagat gttcgacgcc aggaacatga tggccgcctg cgatccgcgc     1140

catggccgct acctgaccgt ggccaccgtg ttccgcgggc ccatgtccat gaaggaggtg     1200

gacgagcaga tgctggccat ccagagtaag aacagcagct acttcgtgga gtggattccc     1260

aacaacgtga aggtggccgt gtgcgacatc ccgccccgcg gcctgaagat ggcctccacc     1320

ttcatcggca acagcacggc catccaggag ctgttcaagc gcatctccga gcagttctca     1380

gccatgttcc ggcgcaaggc cttcctgcac tggttcacgg gtgagggcat ggatgaaatg     1440

gagttcaccg aggcggagag caacatgaac gacctggtat ccgagtacca gcagtaccag     1500

gatgccaccg ccaatgacgg ggaggaagct tttgaggatg aggaagagga gatcgatgga     1560

tagtcggaat agagccgccc caactcagat cctacaacac gcaagttcct tcttgaaccc     1620

tggtgcctcc taccctatgg ccctgaatgg tgcactggtt taattgtgtt ggtgtcggcc     1680

cctcacaaat gcagccaagt catgtaatta gtcatctgga acaaagacta aaaacagcag     1740

agaattgcgg gttctaccca gtcagaagat cacaccatgg agactttcta ctagaggact     1800

tgaaagagaa ctgaggggcc acaaaataaa cttcaccttc cattaagtgt tcaagcatgt     1860

ctgcaaatta ggagggagtt agaaacagtc tttttcatcc tttgtgatga agcctgaaat     1920

tgtgccgtgt tgccttatat gaatatgcag tatgggactt tgaaataatg attcataata     1980

aaatactaaa cgtgtgtctt ca                                              2002


<210> 879
<211> 1930
<212> DNA
<213> Homo sapiens

<400> 879
aggtcaacat cagcacccaa gagctttggg aggaaatgct cagttccaaa ggactaactg       60

ttgttgatgt ctatcaaggc tggtgtggcc cctgcaaacc tgtggtgagc ctcttccaga      120

agatgaggat cgaggtcggc ctggaccttc tgcactttgc attagcagag gcagatcgtc      180

ttgatgtcct cgaaaagtac agagggaagt gcgagccaac ctttctgttt tatgcaatta      240

aagatgaggc tctttctgat gaagatgaat gtgtttccca tggaaagaat aatggtgaag      300

atgaggacat ggtttcatca gagaggacct gtaccttggc catcattaaa ccagatgcag      360

tggcccatgg aaagactgat gagattatca tgaagattca ggaagctggg tttgaaattc      420

taacaaatga agagagaacc atgacagagg cagaagtgcg acttttctac caacacaaag      480

ctggagagga ggcatttgag aagctggtac atcacatgtg cagtggacca agccacctcc      540

tgatcctcac caggactgag ggcttcgagg acgtggtcac tacctggcga accgtcatgg      600

gcccccgtga ccccaatgtg gccaggaggg agcagccaga aagtctccga gctcagtacg      660

gcacagaaat gcccttcaat gccgtccatg gaagccggga cagagaagat gctgacagag      720

aactggcatt gctcttcccc agtttgaaat tttcagacaa agatacagaa gcccctcagg      780

gtgagtccag tacacagcca aggttgaaga tcactgacct agactaaaat gagaggattc      840

agaagtctga ccttagaaca tgagagagtg gaaaacctca ggatgtttca gccaaacaag      900

aagagaagaa aatattgttg aaattaacaa tgatcaggga aaatatcatc tattaagaac      960

agggaaccac attttagctg tagattagga atggtaattt ttatctggtg ttttagtttc     1020

caaaacattt acatattgat ctactcctcg ccctagacca aacctaattc cattcttact     1080

gatatgcaca atcactctct gtcctcattg tcacctctag cccctaaatt cctccctttc     1140

tcagtctacc tactctttgt gactccctca tatcttttcc ccctggcatg gatgtcctgc     1200

tcagacactc cacttagaag acagtttccc tttttcactg tcctcccacc attcattact     1260

cctcctccag ataccaactg ctgatgttgc tctagaaaaa ccaccaaaca tgactgttct     1320

ttccgtgtaa gctatcccac ctcagcggca ccctcactgc tggtgaccag ccttgtaacc     1380

ccctggagat gcccatgttc cttatggtag ctacctctta cttcaaattc ttctgcctcc     1440

ctcatgctcg cagccactct gtgcccacct catcttcgta gggaccttga ttttggggac     1500

acacattgca acttcccact tctgacgaaa ggtctccatg cttttgctgt tttctttact     1560

cttgtcaagg ttgggtactt caagctcaaa gcctatctac cttgatccaa aaactacctt     1620

tccataatgt tctcacatct ttactctgtc ctacctctca ttttcaatcc tgtttaaaag     1680

acgtttaagt gtccaaactt taacctcttg aagctagtcc tctccccact ttccatcttt     1740

aaatgggcat atatacaata aaggctctgt ccatctccat ctcttatata taacaatact     1800

gtgacttaaa aaccaactca gtattggaaa ttttctaaag ttctgtccta gagttctttc     1860

ctgacctcta gctccatact tctgattgcc taataaatat gacatggatg ttcagtggaa     1920

cttcccatct                                                            1930


<210> 880
<211> 1682
<212> DNA
<213> Homo sapiens

<400> 880
ggcagacgtc cctgggttcc ggtgttcgcg gaggagtcga gcagaagaat agaaggaagg       60

tgataggatg tgatgataga atttgtgata gccaagcaac aacttttcct aattcggcat      120

gttaaaaaat aagggtcact catctaagaa agataacttg gcagtcaatg cagttgcttt      180

acaagatcac attttacatg atcttcaact tcgaaatctt tcagttgcag atcattctaa      240

gacacaagta caaaagaaag agaacaaatc tctaaaaaga gatacaaagg caataataga      300

tactggactt aaaaaaacta cacagtgccc caaactagaa gactcagaaa aagaatatgt      360

tcttgatccc aaaccgccgc cgttgacttt ggcacagaag ttgggcctca ttgggcctcc      420

accacctcca ctgtcatcag atgaatggga gaaggtgaaa cagcgctctc tcctgcaagg      480

ggactccgtg caaccatgcc ccatctgtaa agaagaattc gagcttcgtc ctcaggtgct      540

gctttcatgc tcccatgtgt tccacaaagc atgtcttcag gcttttgaaa agttcacaaa      600

taagaaaacc tgtcctctct gtagaaagaa ccagtatcaa acccgagtga tacacgatgg      660

ggcccgcctg ttcagaatca agtgtgtgac cagaatccaa gcctactgga gaggatgtgt      720

tgttagaaag tggtacagaa acctgaggaa aacagtacct cccacagatg ccaagttaag      780

aaaaaaattc tttgaaaaaa agttcacaga aatcagccac cgcatcctgt gctcatacaa      840

caccaacatt gaagagctct ttgcagaaat cgatcagtgc ttggccataa atcgaagtgt      900

tcttcagcag ttggaagaaa aatgtggcca tgagatcaca gaagaggaat gggagaaaat      960

ccaagtgcag gctctgcgcc gggagaccca cgagtgctcc atctgcctgg cccctctctc     1020

cgctgctggc ggtcagcgcg tgggtgcagg caggcgttcc agagagatgg ccctcctgtc     1080

ctgctcacat gtgttccacc atgcgtgtct gctggcacta gaggagttct ccgtgggaga     1140

caggcctcct ttccatgcct gtcctctctg ccgctcctgc taccagaaga agattcttga     1200

atgttgaatt catagtcaag gaaagttagg taattctgag gaaaaaagtt taccatcatt     1260

ttggatgaac tgcatgagtt ctgggttaag tactacaatg taatctgttt cccagggaaa     1320

taagctattg gtagttgtag gaaatcttag tatattttaa aagctgacat cccacctaat     1380

tttaatcttt ggtctctaaa aagtaaattt caaatttatg agtttaatca cttcaaatat     1440

gaatagcaaa aaatgagagc ttgcttactt ctaaaaattg aggttaagat atagctagtg     1500

tctgaacgac actccttaaa gtaagttcca aatgtaaaac actccttaag ttccaaatgt     1560

tttccgctaa tagtctgtcc taaagccttt gccattccta atactcgttt tgtaataatt     1620

gctgtatttc tgtgtaataa aatataaaaa taaaatattc agtggtattc aacatcaaaa     1680

aa                                                                    1682


<210> 881
<211> 600
<212> DNA
<213> Homo sapiens

<400> 881
gcggccgcgg gcaccagagt gccgagccca ggacgccccc ggcccaggcc cttgggttaa       60

tacctctgcc aaccgaggcc accctccctc ggacccccat tcggaggaag cagacccaag      120

ttcgaattct gacattgcca ctgagcagcc gtacaacttt tgggtggaca agtccttcac      180

ttctcgccgg agtgtgtgga ggagcgatgg gcagaaccag cacttccctc aggcactaga      240

cctgtcacga gtgaacttag ttccctccta tactccttca ctctacccta agaacacaga      300

tctatttgag atgattgaga agatgcaggg aagcaggatg gatgaacaac gctgctcctt      360

cccgccgccc ctcaaaacag aggaggacta cattccatac ccgagcgtgc acgaggtctt      420

ggggcgagaa ggacccttcc ccctcatcct gctgccccag tttgggggct actggattga      480

gggcaccaac cacgaaatca ccagcatccc cgagacagag ccactgcagt cgcccacaac      540

caaggtgaag ctcgagtgca accccacagc ccgcatctac cggaagcact ttctcggcaa      600


<210> 882
<211> 3671
<212> DNA
<213> Homo sapiens

<400> 882
ggttaagaga gacgcgcgcg cagtcgcgcg cgggtcgtgc cgtaccaccg tcgcgggcag       60

gctcggccac gagcgccaga gccccgcgcc tcccctcgcg gcctgtccca agtccctgcc      120

ccgcaacaga gcgtcacttc cgccatcccc ggcagcggtt ggggcggggc gcacggggga      180

gggggccagg tcggagggaa gcccgcccgt gcccgagccc gcgcccgagc agggactaca      240

tttcccgagg ggcctcggcg gcggctgcgg cgacgggcgc ggcaacgtcc cccggaagtg      300

gagcccggga cttccactcg tgcgtgaggc gagaggagcc ggagacgaga ccagaggccg      360

aactcgggtt ctgacaagat ggccgggctg ccccgcagga tcatcaagga aacccagcgt      420

ttgctggcag aaccagttcc tggcatcaaa gccgaaccag atgagagcaa cgcccgttat      480

tttcatgtgg tcattgctgg ccctcaggat tccccctttg agggagggac ttttaaactt      540

gaactattcc ttccagaaga atacccaatg gcagccccta aagtacgttt catgaccaaa      600

atttatcatc ctaatgtaga caagttggga agaatatgtt tagatatttt gaaagataag      660

tggtccccag cactgcagat ccgcacagtt ctgctatcga tccaggcctt gttaagtgct      720

cccaatccag atgatccatt agcaaatgat gtagcggagc agtggaagac caacgaagcc      780

caagccatag aaacagctag agcatggact aggctatatg ccatgaataa tatttaaatt      840

gatacgatca tcaagtgtgc atcacttctc ctgttctgcc aagacttcct cctctttgtt      900

tgcatttaat ggacacagtc ttagaaacat tacagaataa aaaagcccag acatcttcag      960

tcctttggtg attaaatgca cattagcaaa tctatgtctt gtcctgattc actgtcataa     1020

agcatgagca gaggctagaa gtatcatctg gattgttgtg aaacgtttaa aagcagtggc     1080

ccctccctgc ttttattcat ttcccccatc ctggtttaag tataaagcac tgtgaatgaa     1140

ggtagttgtc aggttagctg caggggtgtg ggtgttttta ttttatttta ttttatttta     1200

tttttgaggg gggaggtagt ttaattttat gggctccttt cccccttttt tggtgatcta     1260

attgcattgg ttaaaagcag ctaaccaggt ctttagaata tgctctagcc aagtctaact     1320

ttatttagac gctgtagatg gacaagcttg attgttggaa ccaaaatggg aacattaaac     1380

aaacatcaca gccctcacta ataacattgc tgtcaagtgt agattccccc cttcaaaaaa     1440

agcttgtgac cattttgtat ggcttgtctg gaaacttctg taaatcttat gttttagtaa     1500

aatatttttt gttattctac tttgcctttg tacagtttat tttactgtgt ttatttcatt     1560

ttcccaattt gacaatcgta ttttaaaatt gaaactgatg gaacattctt tcttggtctt     1620

caccatctga caaattgaat ggcaagaggt ggattttgcc agtttctttt cactgatgca     1680

gatttgtgtt aagatagtac tgaatggagt atttataaac tggccctgag catgcataaa     1740

gcatcagtat ctgacctttt tttaaccttc taggaatttg aaataaatgt gtttgtgttg     1800

tctgattaga tgatcattgg tgtcttgcca caatgtttaa aaattactgt acaggaaagt     1860

cacagcaaag atagcagttg tgactgacat gtaggacttt cacagttgtg ccacattttt     1920

gcctaaaatt tgggttatga catttttctt ggttcttatc tgaaaatttc atctgtaacc     1980

tttcatgtgt gttaagaaac actgatctga tcatttggga tttgctgagg catttgtgag     2040

tcttccttat aaacctgatg agcagatctc aactatctag cttgtgtgtc atcagaaagg     2100

tttatccctt tgagagtatc aagtcctcag ttaatgattc ttgctttcat ccctccagta     2160

tttgctgtgg gagctcgttt tattctttaa tttggaattc agtaattttt cttctttatt     2220

gacgaattcc tcccctcaca aaactgttct ttcccacctc tctccatatc taattcctga     2280

ttcttgttat ttttaagtca taaatgtagc cagtcataaa tacataaatg ttaaccttcg     2340

ggttgcaacc ttgtctcttg cagtttaagg taatggatat tgtagcccat ttgaattttc     2400

ttcactctta ttctcgtaat tctggagttt cttcagattg tggtgtattt tattgtgctc     2460

ctatgtaaga tgaagaatta actattaaaa ttacattttc aacatacaaa agcttttgat     2520

gactggtaac tggtatcctt ccaaataaat gcattgcttg gtaacaaatg ttagcttaat     2580

tcagaatgaa atagttaaca accctaatat tgtaaaattt gaaaactgat agcagctgtc     2640

atttataaca attcttgggc tgtttaaagg gtacatttga ctatagctaa ggaaattgaa     2700

tctcacttta aaaatgaacc acacaaaact tcaagaaacg aaatagaaat caacatttac     2760

tgcccgtaat attgctcatg gttatagcta gtatcacata gtgatttaca aaccatgaaa     2820

ttccagattt aaatctgttg cactacaaaa atgtctaaat gatgtctgct aaatttgtga     2880

gttatagaag tacagaaata agtcattttc atttcaaatg cagtgaattt ctaatttcat     2940

ggtatcatat ttttttcctt tgcagttttg gtaagactcc cccattactt tgctaagact     3000

tgctttctca accagtggga tgaaacgagt gccagtgtgt tgactgagcc ttcttaggac     3060

ttaaggggct ctgggagagg ccaaggcagc agttgaaaac tgcagcttca cctggccttt     3120

gggcctgttt tccctggccc acacagtgtg gctggttaaa acattctgaa tttgatgcca     3180

acatttttaa aaattgggag atttgcatga aaatccagaa ttcgggtaac ttttgaatga     3240

tctgaagatc tggcaacagt agacctgacc cacctttgtg cacgggactt aactgagagg     3300

atctgagtag cagacaccct aagagcatgt cattgtcttc tcaccagtta ctctccagtt     3360

ggctagagtc ccctccgagc acacctgcta gtccttcccc cttgtaagcc tttgactttg     3420

taatccctgg gctaaaggaa acacattatt caacaaaagt gtttcatgtt tgcccactag     3480

ttgttgggga tgattaggtg gtgagtgaat ggcatggggc tttcctttgg ggaccatata     3540

ctctaatggg gaagggggac agacaaatag ttgtaactct gtcatggaaa agagaagtaa     3600

cttggacaga cttttggatt caggccagat gaacatctcc aggcagaggg aacagcagca     3660

tctgcaaagt c                                                          3671


<210> 883
<211> 3432
<212> DNA
<213> Homo sapiens

<400> 883
ctgcggcggc gcgctccgag cctgcgtcta gggcgccccc gggtcagagc tgtcgccgtg       60

gccgccgctg caagaaccat gtaccgcagc agcgctcgct cctccgtctc ttcccaccgg      120

cctaaagacg acggcggggg cggcccgcgc agcggccgca gctctggctc ctcctcaggc      180

ccggctcgcc gcagctcacc gccgcctccg ccctccggct cctcgtcgcg gaccccggct      240

cgccgacccc gctcgccctc agggcaccgc ggccgccggg cctcgccgtc cccgccacgg      300

ggtcgtcgcg tctccccgtc cccgcctcgg gcccgtcgcg gctccccgtc gccaccgcgg      360

ggccgacgac tcttcccgcc gggcccggcc ggcttcagag gcagcagccg gggggagtcc      420

cgcgccgact atgcccggga cggccgcgga gaccatccag gcgacagcgg cagccggaga      480

cgctctcctg gtctgtgttc tgactctttg gaaaagagct taaggatcac tgttggcaat      540

gaccacttct gtgttagcac accagaacgg cgacggctta gtgatcggct ggggtcacca      600

gtggataatc tggaagacat ggacagggat gacctgactg atgattctgt cttcactcga      660

agctcccagt gctctcgggg tcttgagcga tatatttccc aggaggaagg gcctctcagt      720

cccttcttgg gacaacttga tgaggactac cgaacaaaag aaactttcct gcatcgatct      780

gattatagtc cccatatcag ttgtcatgat gagctgttgc ggggaacaga acggaatcga      840

gaaaaactca aaggctactc catacgatct gaagaaagga gccgggaggc caaaagaccc      900

cgttatgatg acacagtgaa gataaacagc atgggagggg atcacccaag ttttacatca      960

ggaactcgca actatcgaca gcgtagaaga agcccaagtc ctaggtttct cgaccctgag     1020

tttcgagaac tggatcttgc cagacgaaag cgagaggaag aggaggagcg aagtaggagc     1080

ttgagtcagg agctggttgg agttgatggt ggtggtactg gctgttccat ccctggattg     1140

tcaggtgtcc taacagcatc ggagccagga tattctttgc atcggcctga ggaagtatct     1200

gtgatgccca agaaatccat tttgaagaag cggattgagg tggacataat ggagccctcc     1260

atgcagcttg agagtttttc cagcagtacc agctccagcc aggatcaccc tctctactct     1320

gggcacccat cccttccact aagtggtgct attgctgctt ttgcctcaga gattgaaaac     1380

aaggggacta tggtagagac tgccttgaag gaacctcagg gcaacctcta ccaatggggt     1440

ccccttcctg ggattcccaa agacaacagt cctctcagag aaaaatttgg aagttttcta     1500

tgccacaagg ataatttgga tttgaaggct gagggacctg agcgacacac agacttcctg     1560

ctgccccatg agagagctag ccaggatggc agtggttttt cccgcattct gagcatgttg     1620

gctgattcta ccagtacaca ggaaaaaagg cgacgtagct ttcccgacat tgaagatgag     1680

gagaaatttc tctatgggga tgaagaagag gatttaaagg cagaatccgt accaaagccc     1740

cttgggagct ctgagagtga agttatgagg cagaaggcaa gctccctgcc gtcttcagct     1800

ccagctgtaa agctagaatc actagaagag accaatccag aatatgcgaa gatccatgac     1860

ttgctcaaga caatagggct ggatattgga gtagcagaga ttagtcaatt ggctgcacgc     1920

acccaggaac gacttcatgg caagaagcca tcattacgct cctcagctga ccgccgttcc     1980

tcagttgacc gatacttttc agctgaccac tgttcctcag ttgaccaccg cttctcagct     2040

gaccgctgtt cctcagttga ccactgcttc tcagctgatc gacgttcctc agatccccac     2100

agactagaga gcagggaggc acatcatagc aatacccact ctccagaggt gtcccatcca     2160

cacccacctt ctcctgtgga tccttacctg ctcacaaaaa acagccctcc attcctaaag     2220

tctgaccatc cagtgggtca tatttcagga ccagaggtgg ttggtagtgg gtttcagtca     2280

tctgttgcag tcaggtgcat gttgccatca gccccatctg ccccaattag acttccacac     2340

actgctgctt tatctcagtt tcacatgcca agggcctctc agtttgctgc agctcggata     2400

cctccgaact accagggacc tgccattccc cctgcctctt ttgatgccta taggcactac     2460

atggcatatg cagcctccag atggcccatg tatcccacct ctcaaccgtc aaaccaccct     2520

gtacctgaac cacacaggat aatgccaata accaaacaag ctactcgtag ccgtcccaat     2580

cttcgtgtga tccccactgt gactcctgat aagcctaagc agaaagagtc tctgcgaggc     2640

tcaattcctg cggcccaagt gcctgtccag gtgtccattc catcactcat aagatataat     2700

ccagagaaga tctctgatga gaagaaccgt gcttcccaga agcaaaaggt tattgaagag     2760

agggaaaaac taaagaatga ccgggaagcc cgccagaaga agatgtacta tcttaggacc     2820

gagttagagc ggcttcataa acaacaagga gaaatgctgc gcaagaaacg aagggagaag     2880

gatggccaca aagatcctct cttggtggag gtgagtcggc ttcaggataa cattatgaag     2940

gacattgcag agctacggca agaggcagaa gaggcagaaa agaagcaatc tgaactggac     3000

aaagtggctc agatcttggg aattaacatc ttcgataaat cccagaagtc tttaagtgac     3060

agtagagagc ctacagagaa gcctgggaaa gcagaaaaat ctaagagccc agaaaaagtg     3120

tcatcgttct caaactcctc ctccaacaag gaatcaaaag taaacaatga gaagtttcgt     3180

actaagagcc ccaagcctgc cgaaagcccc cagtcagcca ctaagcagtt ggatcagccc     3240

actgctgctt atgagtatta tgatgctggc aatcactggt gcaaagactg caacaccatc     3300

tgtgggacca tgtttgattt cttcactcat atgcacaata agaagcacac acaggggcaa     3360

ttccaaaagt cttcagattt ccaaaaggaa ggactgcagc agacatttct gcccccagaa     3420

aggcagggat ag                                                         3432


<210> 884
<211> 2394
<212> DNA
<213> Homo sapiens

<400> 884
gatctcagtt ttatcatgaa tgacttctcc attgtgattc ttgatttcct tcatgggtta       60

atttagaggt tatgtatgta tgtctgtgtg tgtctgttgc taaggtcacc atggctgacc      120

gggctgctgc cgaaagggcc tgcaaggatc ccaatcccat cattgatggc agaaaggcca      180

acgtgaacct ggcatactta ggagcaaaac caaggatcat gcaaccaggt tttgcctttg      240

gtgttcaaca acttcatcca gcccttatac aaagaccttt cgggatacct gcccactatg      300

tctatccgca ggcttttgtg cagccgggag tggtcattcc acacgtccag ccgacagcag      360

ctgccgcctc caccacccct tacattgatt acactggagc tgcatacgca caatactcag      420

cagctgctgc tgctgccgcc gccgctgctg cctatgacca gtacccctat gcagcctctc      480

cagctgctgc aggatatgtt actgctgggg gctatggcta cgcagtccag cagccaatca      540

ccgcagcggc acctgggaca gctgccgccg ccgctgcagc agctgctgcc gctgcagcat      600

ttggccagta ccagcctcag cagctgcaga cagaccgaat gcaatagacc agccatctga      660

tcaaagttga attgttttct ctttccctcc caattttcca atttttagta gctaataaga      720

gagttaacat tgacttaaca gctttaaaaa aaaaaacagc catgctattg tgaagcagag      780

ttattatttt ttttatactc caggtagtgt tctagatgag aaagaggtaa gaatgagggg      840

aatgggcaca attttggaaa tcaatcccaa agagcctgag taaatgaaag gccactacga      900

aatgacgcca ggagtaacaa cggaacttca cttttgtaac gggattttta tttttgctct      960

ttttatagta tcagggaagc aaactgcctt ttacaagtta gaaaatgctg tttgaatcta     1020

gttgaaccag ggaatacaga gcgagcaata tgtagcttga attacattta aaagcagatt     1080

ttttacaaac aaaatggcga aagcactgat tgtcattttt agcagtcact taaggcctat     1140

agaacttttt tcaagtcgga aggtcctgtt cttactatct caaaaatggg catcgaacaa     1200

tcaatctagg agcgtggcag tgggtaaaat ggtggacagg caccaaagct attttctcat     1260

ctgtcctgtg gatgagtgga actgtggaac aagtgatgtg gaattaatgg gtgcaacagc     1320

tgtacagaca atcaataaca cacacagttc tggaaagaac acatcacttg tgcttgtttg     1380

atgagcttgt cacattctaa tccctctccc catcctgttt caattttggg aaacttgtat     1440

ctgctggtgt cagcaattct gattctgaaa taggatcagg cttttactac aacagccttc     1500

tctttctatt tattgtgtcg actcgtggct tatgaataaa ggcaggcaaa gtttgcagaa     1560

ctgtcttaag gacatttatt ttttttccct ttttaagtaa ttttacactt tagtatctat     1620

ttcagagtca tatttaaaac tatttattag tgactacagt acatgagaca acaaggttac     1680

tgagattaca attcttcaaa ggttaatgat aatgtggttt atactgtgcc ttaatagtaa     1740

tgctatttaa gatatttatt tttaagtttt actatgctgc actctaaaga aaggaacttt     1800

agatgtgaca ctgtaaaatt atgtattcat ctcatggcat aaattattta gtaagtctag     1860

atgtagcgta ttaaatatta acctattcaa ctaaagatgt tgacttggat ttatttaaat     1920

tcatatgtgc actgtataag agagtactct tacattaaca cattttagtt tagtttttag     1980

attttttttt aaacgatata ttgctagttt catgcttcct cctctgattt tgcctgtgta     2040

gatttcattt attggtaatt cattagttta acactattat gtagttttta aatgctgctt     2100

tacatttttc ttctgaaact gcaatacttg caatttttat tcttaaacta aattgaatac     2160

tattttacac tgtattggat ttttatactt gaacaatttc atacaaggga agacaggtta     2220

gcatttttat ggactttctc cattatcact ggatttactt taagtattcc catactagac     2280

agtgttatgt aatgtagaca tgactctcct gtgcaaatta tttattcgtt gtgtatattg     2340

ctttataaca tttcagatct tctaatctat tcacttgtat taaatataat tttt           2394


<210> 885
<211> 626
<212> DNA
<213> Homo sapiens

<400> 885
gggcgggcca gggccgcact ccggagactc gcggttgcta cgcgcaccat ggctggagcg       60

cccacggtct cgcttcctga actccgttca ctcctagcct ccggacgggc ccggctcttc      120

gacgtgcgct ctcgcgagga ggcggcagct gggaccatcc caggggcgct caacatcccg      180

gtgtccgagt tggagagtgc tctgcagatg gagccagctg ccttccaggc tttatattct      240

gctgagaagc caaagctgga agatgagcat ctcgttttct tctgtcagat gggcaagcgg      300

ggcctccagg ccacgcagct ggcccggagt cttggataca ctgggtacgg ggaggtgtgg      360

ctgctagctg ggaggtgatg gggactgcct gtcattcctg tcagtctctc acgcttcttt      420

gtctccacag ggctcgcaac tacgctggag cctatagaga atggttggag aaagagagtt      480

aggcaggagg cagcttactg attgccaccc cctggcccct taatggccac cttaactaag      540

ggtgtgaacg ggctgacttg gtgaattggg caactcctta tagtgttgtg cacacaaaag      600

catcaaataa agaacattta atcaaa                                           626


<210> 886
<211> 2145
<212> DNA
<213> Homo sapiens

<400> 886
ccggagcctg cggcgggcgg ctgtgacggc cccggcgctg acggcggcgg ccgggggggc       60

ggtgtcgacg cccgcggcgc cggctggggc atcaccgcgg gcctcgaccc cgaaatggcg      120

ctgctggccg aacacttgct gaagccgctg cccgcggaca agcagatcga gaccgggccc      180

ttcctcgagg cggtgtccca cctgccgccc ttcttcgatt gccttgggtc cccagtgttt      240

actcccatca aggcagacat aagcggcaac atcacgaaaa tcaaagctgt gtacgacacc      300

aacccagcca agttccggac cctgcagaac atcctggagg tggagaaaga aatgtatgga      360

gcagagtggc ccaaagtagg ggccacactg gcgctgatgt ggctgaaaag aggcctccgc      420

ttcatccagg tcttcctcca gagcatctgc gacggggagc gggacgagaa ccaccccaac      480

ctcatccgtg tcaacgccac caaggcctac gagatggccc tcaagaagta ccatggctgg      540

atcgtgcaga agatcttcca ggcagcactg tacgcagcac cctataagtc tgacttcctg      600

aaagcgctct ccaaggggca gaatgttacg gaggaggagt gcctggagaa gatccgcctc      660

ttcctagtca actacacggc gaccatcgat gtcatctacg agatgtacac ccagatgaac      720

gctgagctta actacaaggt gtaggcatgc ccactgctgg acacgtcccc gactcgtggc      780

cacatggaga aacaggcaaa ccagaatcac tgtgaatcaa gtcggtgaac tgcccctggc      840

ctgtgtcccc cagagcagcc cagggtcctg ccagagtctg caggggacag ccctcgtttt      900

ttaagtcttt tttttttttt tttttggtct attctaaagg accagtaaat aatgatctta      960

cttccaaatc tccttggaat ttcacgacag cacagactga ctttatacct tcatttcagc     1020

gtggtaaaaa ccgattaaca cttctaatga gtcaagtcct agggtttttt ggttttgttt     1080

tgttgccaac gaggaacaca gctctggggg aatggtgtca tccacctcgc tttaaaaata     1140

agcacatgat ggctgggcac cgtggctcac gcctgtaatc ccagcacttt gggaggctga     1200

ggcgggtgga tcacctgagg tcgggagttt gagaccagcc tggccaacat ggtgaaaccc     1260

catcgctact aaaaatataa aaaattagct gggcatggtg gcgcacgcct gtagttccag     1320

ctactcagga ggctgaggca ggagaatcgc ttgaacccgg gaggtggagg ttgcagtgag     1380

ctgagatcgc accattgcac tccagcctgg gcaacaagag cgaaactctg tctcaaaaaa     1440

aaaaaaaaga ggtgggtgga ttacttgagg tcagggtttg agatcagcct gaccaacatg     1500

gtgaaaccct atctctacta aaaatataga attagccagg catggtagcg cacgcctgta     1560

atcccatctt cttgggaggc tgaggcagga gaatcgctag aaactgggag gtggaggtta     1620

cagtagccga gatcgcgcca ctgcattcca gcctgggcaa caaaagcgaa actctgtctc     1680

aaaaaagaaa aaaaagaaaa aaaagcacgt gaccttatga ggctctcgct gtattgttat     1740

tttaaggact ataaagagtt tgatttaaaa ttatgcaggg cccctatgtg ggatttttta     1800

aaaagcaaac tggtgtgtat tctcatgtgg tttgcacagc ccagcctcac agcactattg     1860

taaaccctgc tctttctgtc tcgctagaca gatttttttg tttgttttct tttttctggt     1920

tgttttttgt tgttgttgtt gttgttttac agctgaaacc aaccagcaag cccttgatga     1980

ccaagaggcg tttctttcaa agctataggg cacaaacaat tgaccataga tgactccgtt     2040

tgcattcttc tgcagaatta tttccttcag ggacagattt tccaacctaa gaaactacct     2100

accgtgtgta ttctcttgac ggggagagat gaacccttca gctgc                     2145


<210> 887
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 887
ctgactcaga tggaggaagc ccagaggaaa cggacacaac tccgggaagc ctttgagcag       60

ctccaggcca agaaacaaat ggccatggag aaacgcagag cagtccagaa ccagtggcag      120

ctacaacagg agaagcatct gcagcatctg gcggaggttt ctgcagaggt gagggagcgt      180

aagacaggga ctcagcagga gcttgacagg gtgtttcaga aacttggaaa cctgaagcag      240

caggcagaac aggagcggga caagctgcag aggtatcaga ccttcctcca gcttctgtat      300

accctgcagg gtaagctgtt gttccctgag gctgaggctg aggcagagaa tcttccagat      360

gataaacccc agcagccgac tcgaccccag gagcagagta caggagacac catggggaga      420

gaccctggtg tgtccttcaa ggctgttggt ctacaacctg ctggagatgt aaatttgcca      480

tgacttcctg gaggacagca gcatggagaa agatcctaga aaaggtcaga cccaactcag      540

gccttggtgt ccctggactg caagtgtgga aggagggaaa gcctggttta cctctctctg      600

catctgagct ctgctaccca tggagcagat ggatggtggg aacaggaaag agcttatgtt      660

acacctcatt cccatgctta gcccacccag agctaacccc tgtcttcttc cccaggcctc      720

tgacttccct cacctcccaa ccatcattac aggaaagact gtgaactcct gagttcagct      780

tgatttctga ctacatccca gcaagctctg gcatctgtgg attaaaatcc ctggatctct      840

ctcagttgtg tatttgttca tcttcatatg ctggcaggaa caactattaa tacagatact      900

cagaagccaa taacatgaca ggagctggga ctggtttgaa cacagggtgt gcagatgggg      960

agggggtact ggccttgggc ctcctatgat gcagacatgg tgaatttaat tcaaggagga     1020

ggagaatgtt ttaggcaggt ggttatatgt gggaagataa ttttattcat ggatccaaat     1080

gtttgttgag tcctttcttt gtgctaaggt tcttgcggtg aaccagaatt ataacagtga     1140

gctcatctga ctgttttagg atgtacagcc tagtgttaac attcttggta tctttttgtg     1200

ccttatctaa aacatttctc gatcactggt ttcagatgtt catttattat attcttttca     1260

aagattcaga gattggcttt tgtcatccac tattgtatgt tttgtttcat tgacctctag     1320

tgataccttg atctttccca ctttctgttt tcggattgga gaagatgtac cttttttgtc     1380

aactcttact tttatcagat gatcaactca cgtatttgga tctttatttg ttttctcaaa     1440

taaatattta aggtta                                                     1456


<210> 888
<211> 2650
<212> DNA
<213> Homo sapiens

<400> 888
agaaggccaa gccccaagcc cagcctctcg ccagctggga gtcgcgcgct gcccacctcg       60

ctgcccaggc ccccgacgcc gcggcaggag ccccccaaga gcgcgggaag ccccgtggac      120

ctggcgctcc cggctcgggc gtggacgggg cgggcgccgg ggcggggcgc gcgtcctcgc      180

gggtctgaat ggaagggtcg aggtcgtcgt cggcggcgag cagatcctga agccagaact      240

ccaccccggc gcccgcgcca tgcggcggga gaggtgcggc gccccccacc cgcgtcgccg      300

ccatggaggt gctgcggcgc tcctcggtct tcgccgccga gatcatggac gcctttgacc      360

gctcgcccac agacaaggag ctggtggccc aggccaaggc gctgggccgg gagtacgtgc      420

acgcgcggct gctgcgcgcc ggcctctcct ggagcgcgcc cgagcgtgcc gcgccggtcc      480

cgggacgcct ggctgaggtg tgcgcggtgc tgctgcgcct gggcgatgag ctggagatga      540

tccggcccag cgtctaccgc aacgtggcgc gtcagctgca catctccctg cagtctgagc      600

ctgtggtgac cgatgcgttc ctggccgtgg ctggccacat cttctctgca ggcatcacgt      660

ggggcaaggt ggtgtccctg tatgcggtgg ccgcggggct ggccgtggac tgtgtgaggc      720

aggcccagcc tgccatggtc cacgccctcg tggactgcct gggggagttc gtgcgcaaga      780

ccctggcaac ctggctgcgg agacgcggcg gatggactga tgtcctcaag tgtgtggtca      840

gcacagaccc tggcctccgc tcccactggc tggtggctgc actctgcagc ttcggccgct      900

tcctgaaggc tgccttcttc gtgctgctgc cagagagatg agctgcccac ctggcagtgg      960

ccgcagcctg gccctctggg cccaacgcag gaggccctca gcacccgaac acatcttcct     1020

cctccccacc cgagcctgga gcactctaac cctcggagac cccctaagcc ccgttcctcc     1080

gcagacccag gccctccgga aggggtgagt ggggaggggc tttcctgagc ctggagctgg     1140

gctttggggc agcctgcgac cctccccgct tgtgtccctt ctcctgtgat ctctgtgttt     1200

tcccttttct ttctggggcc aggaagtcag ggtcaactcc caggcctcag atgcaggggc     1260

ccagaacacc tgctctcacc tgagccccag gtgaaggggc ccgggaacac ctgctctcac     1320

ctgagcccca ggtgaagggg cccgggaaca cctgctctca cctgaacccc aggtgaaggg     1380

gcccggaaca cctgctctca cctgagcccc aggtgaaggg gcccggaaca cctgctctca     1440

cctgagcccc aggtgaaggg gcccgggaac acctgctctc acctgagccc caggtgaagg     1500

ggcccgggaa cacctgctct cacctgaacc ccaggtgaag gggcccagaa cacctgctct     1560

cacctgagcc ccaggtgaag gggcccggaa cacctgctct cacctgagcc ccaggtgaag     1620

gggcccggga acacctgctc tcacctgagc ccctggtgaa ggggcccgga acacttgctc     1680

tcacctgagc cccaggtgaa ggggcccgga acacctgctc tcacctgagc ccccggtgaa     1740

ggggcccgga acacttgctc tcacctgagc cccaggtgaa ggggcccgga acacctcctc     1800

tcacctgagc cccaggtgaa ggggcccgga acacctcctg tcacctgagc cccaggtgaa     1860

ggggcccggg aacacctctc acctgaaccc gggggtccca tcccaggaag aagggccatc     1920

tcaggacatg agtcctcagg ggccctgcac attcaatctg aaggtgaccc tggcctggct     1980

gaagctggaa gagctgtggg gactcagcct gtaaacagag cgtaaggttc acatgctggt     2040

tgcttaatcc gtttctggag gaagagtatg acacccactt gtgatggggt ccttgtgcgg     2100

tggggaccgg ggccggcggg ctccaggcca gcacacctaa cccatggatg tggaacctac     2160

ggccgagaag gaatgttgca tgagtcggat cccagtccat tgtcagtgga gggtgagggt     2220

gaccccatct gctatttttg tgctcatcct catacaacca tttggggatg tgcctattag     2280

ggctccgtaa gaactcagat gcctgggaag cccagcccct caggtgcccc cacacacagc     2340

cttcccttga cgcctacatt tctaggcaca tgtgaggcat ctttcctgga gccccgagcc     2400

agccctgtcc ctccccagtg cagcatggca ctcaggagat acaggctgga catggggcag     2460

tcgttctggg gaggcctggc ctagcagcca cccacctgag ccctcccggc caggcttcgt     2520

gctggggtgg gccatgtgcc aggacaggag ggtcccggcg gaaagccagc cccggactca     2580

tcgtgacatt gagatcccac tggagggtag gggtggtaat aaacttctcc aaacgatcgt     2640

tgtcatttta                                                            2650


<210> 889
<211> 3148
<212> DNA
<213> Homo sapiens

<400> 889
tcgggtgact ccgcaacctg tcgctcaggt tcctcctctc ccggccccgc cccggcccgg       60

ccccgccgag cgtcccaccc gcccgcggga gacctggcgc cccggccgag gcgcgaacag      120

acggacgcac cggcgagcgc cgaggggaca ggccgagcgc ggggcgccgg aggcaggtgt      180

gggacaggca ctggcctcag accggggcca cactgaggtc tgcccttctc ccgctggccg      240

ccacccaaga caccatgagc cagtccgggg ccgtgagctg ctgcccgggt gccaccaatg      300

gcagcctggg ccggtccgac ggtgtggcca agatgagccc caaggacctg tttgagcaga      360

ggaagaagta ttccaactcc aacgtcatca tgcacgagac ctcgcagtac cacgtccagc      420

acctggccac attcatcatg gacaagagcg aagccatcac gtctgtggac gacgccatcc      480

ggaagctggt gcagctgagc tccaaggaga agatctggac ccaggagatg ctgctgcagg      540

tgaacgacca gtcgctgcgg ctgctggaca tcgagtcaca ggaggagctg gaagacttcc      600

cgctgcccac ggtgcagcgc agccagacgg tcctcaacca gctgcgctac ccgtctgtgc      660

tgctgctcgt gtgccaggac tcggagcaga gcaagccgga tgtccacttc ttccactgcg      720

atgaggtgga ggcagagctg gtgcacgagg acatcgagag cgcgttggcc gactgccggc      780

tgggcaagaa gatgcggccg cagaccctga agggacacca ggagaagatt cggcagcggc      840

agtccatcct gcctcctccc cagggcccgg cgcccatccc cttccagcac cgcggcgggg      900

attccccgga ggccaagaat cgcgtgggcc cgcaggtgcc actcagcgag ccaggtttcc      960

gccgtcggga gtcgcaggag gagccgcggg ccgtgctggc tcagaagata gagaaggaga     1020

cgcaaatcct caactgcgcc ctggacgaca tcgagtggtt tgtggcccgg ctgcagaagg     1080

cagccgaggc tttcaagcag ctgaaccagc ggaaaaaggg gaagaagaag ggcaagaagg     1140

cgccagcaga gggcgtcctc acactgcggg cacggccccc ctctgagggc gagttcatcg     1200

actgcttcca gaaaatcaag ctggcgatta acttgctggc aaagctgcag aagcacatcc     1260

agaaccccag cgccgcggag ctcgtgcact tcctcttcgg gcctctggac ctgatcgtca     1320

acacctgcag tggcccagac atcgcacgct ccgtctcctg cccactgctc tcccgagatg     1380

ccgtggactt cctgcgcggc cacctggtcc ctaaggagat gtcgctgtgg gagtcactgg     1440

gagagagctg gatgcggccc cgttccgagt ggccgcggga gccacaggtg cccctctacg     1500

tgcccaagtt ccacagcggc tgggagcctc ctgtggatgt gctgcaggag gccccctggg     1560

aggtggaggg gctggcgtct gcccccatcg aggaggtgag tccagtgagc cgacagtcca     1620

taagaaactc ccagaagcac agccccactt cagagcccac ccccccgggg gatgccctac     1680

caccagtcag ctccccacat actcacaggg gctaccagcc aacaccagcc atggccaagt     1740

acgtcaagat cctgtatgac ttcacagccc gaaatgccaa cgagctatcg gtgctcaagg     1800

atgaggtcct agaggtgctg gaggacggcc ggcagtggtg gaagctgcgc agccgcagcg     1860

gccaggcggg gtacgtgccc tgcaacatcc taggcgaggc gcgaccggag gacgccggcg     1920

ccccgttcga gcaggccggt cagaagtact ggggccccgc cagcccgacc cacaagctac     1980

ccccaagctt cccggggaac aaagacgagc tcatgcagca catggacgag gtcaacgacg     2040

agctcatccg gaaaatcagc aacatcaggg cgcagccaca gaggcacttc cgcgtggagc     2100

gcagccagcc cgtgagccag ccgctcacct acgagtcggg tccggacgag gtccgcgcct     2160

ggctggaagc caaggccttc agcccgcgga tcgtggagaa cctgggcatc ctgaccgggc     2220

cgcagctctt ctccctcaac aaggaggagc tgaagaaagt gtgcggcgag gagggcgtcc     2280

gcgtgtacag ccagctcacc atgcagaagg ccttcctgga gaagcagcaa agtgggtcgg     2340

agctggaaga actcatgaac aagtttcatt ccatgaatca gaggaggggg gaggacagct     2400

aggcccagct gccttgggct ggggcctgcg gaggggaagc ccacccacaa tgcatggagt     2460

attattttta tatgtgtatg tattttgtat caaggacacg gagggggtgt ggtgctggct     2520

agaggtccct gcccctgtct ggaggcacaa cgcccatcct taggccaaac agtacccaag     2580

gcctcagccc acaccaagac taatctcagc caaacctgct gcttggtggt gccagcccct     2640

tgtccacctt ctcttgaggc cacagaactc cctggggctg gggcctcttt ctctggcctc     2700

ccctgtgcac ctggggggtc ctggcccctg tgatgctccc ccatccccac ccacttctac     2760

atccatccac accccagggt gagctggagc tccaggctgg ccaggctgaa cctcgcacac     2820

acgcagagtt ctgctccctg aggggggccc gggaggggct ccagcaggag gccgtgggtg     2880

ccattcgggg gaaagtgggg gaacgacaca cacttcacct gcaagggccg acaacgcagg     2940

ggacaccgtg ccggcttcag acactcccag cgcccactct tacaggccca ggactggagc     3000

tttctctggc caagtttcag gccaatgatc cccgcatggt gttgggggtg ctggtgtgtc     3060

ttggtgcctg gacttgagtc tcaccctaca gatgagaggt ggctgaggca ccagggctaa     3120

gcaattaaac cagttaagtc tcccagga                                        3148


<210> 890
<211> 2111
<212> DNA
<213> Homo sapiens

<400> 890
cgggagcggg gcggcgggcg ccggggctgg catggcgtgg ccctgtatca gccgcctgtg       60

ctgcctggcg cggcgctgga accagctgga ccgctccgac gtggcggtgc cgctcactct      120

gcacggctac tcggacctcg acagcgagga gccgggcacg ggcggcgccg cctcgcgcag      180

gggccagcct cccgcgggcg cccgggattc cggccgggac gtgccgctca ctcagtacca      240

gcgggacttc ggcttgtgga ccacgcccgc cgggcccaag gatccgccgc cggggcgcgg      300

accgggggcg ggcggccgca ggggcaaatc ctccgcgcag tcctccgcgc cacctgcgcc      360

cggcgcccgc ggggtctacg tgctgcccat cggcgacgcg gacgcggctg cagcagtgac      420

cacgtcgtac agacaggaat tccaggcttg gactggagtg aagccctcaa gatccacaaa      480

gacaaaacca gcccgagtca tcacaaccca cacttcggga tgggacagca gccctggggc      540

cggcttccag gtcccagagg tgaggaagaa gttcactcct aacccctccg ccatctttca      600

ggcctcagct ccccggattc tcaacgtgtg actgcctgca ccgtgacacc atggctgccg      660

acaggacagg gctggggagc ggcctcagga cccactgccg cggggctggg cgagagcatg      720

gcatgggccc ctgcgggagg gcacagcccc tctcaaagct gtcaccaggg ccaaagtgct      780

ggtgtggagc agatgcaccg atggacttgg cacacccagc tcagcctcaa gcatcctctt      840

gagaagcctg tggaaggctc ctgcgttcgt taactgccat ctggccgtct ctcagttttg      900

aaatctctga ggagcctgag gatcaagtca gttgggaacc gaattggtcc atggaagctg      960

aggaatgtgg acacatccgg cccttgaaag aaccagttat gtccactttt ggtggatttc     1020

ccaggatgcg tgagcacttg attaatttca taacctacag tgagaccctt ggctcttcct     1080

acaaatggcc cctgcagttg aagctgttgg aatcttgggc cgtcacctgc atgactcatg     1140

gtgatgctga gtatccagga ggaaatttcc agaagaaaca gaccgtcagt cacgggcttc     1200

cacttcacag acctccttat ggccaagatg agcctcatgt tttaacaaaa cagttcttgg     1260

gattgaatga ctcacattta ccttgtgcta ggttctaaag attgaatcca cattttgtta     1320

ctaatgattt tcccgctaac ataaggatga tgagcagggc actatcatac acactggctg     1380

agaactggaa ctgtttttgg gaaggtggca tttgtctcat tccctgaaat accttaaaat     1440

gtcctctaca ccaacccttc cgtctaccct gctcacatgt acagtgacgg ggaactcacc     1500

accttttgaa gaggcagttc attttctttg caaagctctc tcctaacttc ctccgtaaat     1560

tccagccagc atggccacat gggtcacgcc tggtgccttc acacgtttga ggggtcttcg     1620

tctcttttta aagcttagag gtacaagctc aggacagtct tcagtaagga aatttgtgga     1680

tttccctttg gatctttctt cctctccagc ccacaagtgg ctctagtgag acgagcattt     1740

aagctgcagg tggtggcact cgggtctcag agccaccaga cgtgcaggtg ggacagtggt     1800

tccagctccg actgcctgtc agcgtccctc ccaggtgcta gccctggcag gcacagccct     1860

cccctcatgc cagcaaagga aatgctcttg atgagaggct cgctttaaag aagcccaaag     1920

cgtgtgctta tccaaggggt tcagctattc ctgacttcac ggcttgcatg tttgattttt     1980

ctaagagaaa agaggctgcc tgctgggtgt ctgtggaaat gagattaaaa actgtacaat     2040

ctcagatttt actaaaatgc aaaaatgtag tttcagtttc ttaaattata agcacgagtc     2100

ttctcacgct t                                                          2111


<210> 891
<211> 5916
<212> DNA
<213> Homo sapiens

<400> 891
ggctctgtgt atgaatgaca aggatacctt cagccagctc attctggatg aatgaatgat       60

tacactaagt gtcctccaca ttcctctgtg ggctcacttc atggactcac tttgcgtgct      120

tgttaaatgt gctgtgttgc tcccaagacc atgtaaagcc tactgaccac taacctccct      180

cacagcagaa actagacgtc aggttaaaat gggcaactcc gacagtcagt acacccttca      240

aggatctaaa aatcatagca atactattac tggtgctaag caaattcctt gctccctgaa      300

aatacgtggc attcatgcaa aagaggaaaa gtcattgcat ggatggggtc acggaagcaa      360

cggagcaggt tacaagtcca ggtccctggc ccgaagctgc ctttctcact ttaagagtaa      420

ccagccttac gcatcgagac tcggtggccc cacatgcaag gtctccagag gtgttgccta      480

ctccacgcac aggacaaatg ccccagggaa ggatttccag ggcatcagtg ctgctttctc      540

aactgagaat ggcttccact ctgttggcca cgagctggca gataaccaca tcacctccag      600

agactgcaac ggacaccttc tcaactgcta cgggaggaat gagagcattg cctccacccc      660

accgggcgaa gaccgcaaga gcccccgagt gctcatcaaa acgctgggga agctggatgg      720

gtgtttaagg gtcgagttcc acaatggtgg caaccccagc aaagtgcctg cagaggactg      780

cagtgagccg gtgcagctgc tgaggtactc acctacctta gcatcggaaa cctcccctgt      840

gcctgaagcc aggagggggt ccagcgccga ttccctgccc agccatcgcc cctctcccac      900

ggactctcgc ctgcggtcca gcaaaggcag ctccctgagt tctgagtcat cctggtacga      960

ctccccttgg ggcaatgctg gagagctgag cgaggctgag ggctccttcc tggcccccgg     1020

catgcctgac cccagtctcc atgccagctt cccacctggc gatgccaaaa agcctttcaa     1080

ccaaagctct tccctctcct ccctccggga actgtacaaa gatgccaacc tggggagcct     1140

ctccccctca ggtatccgcc tttctgatga atacatgggc acgcatgcca gcctgagcaa     1200

ccgtgtctct tttgcttccg acattgatgt gccctccaga gtggcacacg gggaccccat     1260

ccagtacagt tccttcactc tcccctgtcg gaagcccaaa gcctttgttg aggatactgc     1320

gaagaaggac tccctcaaag ccaggatgcg acggatcagt gactggacgg gaagcctctc     1380

aaggaagaaa aggaaactcc aggagccgag gtccaaggag ggcagtgact actttgacag     1440

tcgctctgat ggactgaata cagatgtgca gggatcctcc caggcatctg cttttctgtg     1500

gtcagggggc tctactcaga tcctgtctca gagaagtgaa tccacacatg cgattggcag     1560

cgatcccctc cggcagaaca tttatgagaa tttcatgcga gagttggaaa tgagcaggac     1620

caacactgag aacatagaaa catctacaga aaccgccgag tccagcagcg agtcactcag     1680

ctctctggaa cagctggatc tgctctttga gaaggaacag ggggtggtcc ggaaggccgg     1740

gtggctcttc ttcaagcccc tggtcactgt gcagaaggaa aggaagcttg agctggtggc     1800

acgaaggaaa tggaaacagt actgggtaac gctgaaagga tgcacgctgc tgttttatga     1860

gacctatggg aagaattcca tggatcagag cagtgcccct cggtgtgctc tgtttgcaga     1920

agacagcata gtgcagtctg ttccagagca tcccaagaaa gaaaatgtgt tctgcctcag     1980

caactccttt ggagatgtct accttttcca ggccaccagc cagacagatc tagaaaactg     2040

ggtcactgct gtacactctg cttgtgcatc cctttttgca aagaagcatg ggaaagagga     2100

cacgctgcgg ctgctgaaga accagaccaa aaacctgctt cagaagatag acatggacag     2160

caagatgaag aagatggcag agctgcagct gtccgtggtg agcgacccaa agaacaggaa     2220

agccatagag aaccagatcc agcaatggga gcagaatctt gagaaatttc acatggatct     2280

gttcaggatg cgctgctatc tggccagcct acaaggtggg gagttaccga acccaaagag     2340

tctccttgca gccgccagcc gcccctccaa gctggccctc ggcaggctgg gcatcttgtc     2400

tgtttcctct ttccatgctc tggtatgttc tagagatgac tctgctctcc ggaaaaggac     2460

actgtcactg acccagcgag ggagaaacaa gaagggaata ttttcttcgt taaaagggct     2520

ggacacactg gccagaaaag gcaaggagaa gagaccttct ataactcagg tcgatgaact     2580

tctgcatata tatggttcaa cagtagacgg tgttccccga gacaatgcat gggaaatcca     2640

gacttatgtc cactttcagg acaatcacgg agttactgta gggatcaagc cagagcacag     2700

agtagaagat attttgactt tggcatgcaa gatgaggcag ttggaaccca gccattatgg     2760

cctacagctt cgaaaattag tagatgacaa tgttgagtat tgcatccctg caccatatga     2820

atatatgcaa caacaggttt atgatgaaat agaagtcttt ccactaaatg tttatgacgt     2880

gcagctcacg aagactggga gtgtgtgtga ctttgggttt gcagttacag cgcaggtgga     2940

tgagcgtcag catctcagcc ggatatttat aagcgacgtt cttcccgatg gcctggcgta     3000

tggggaaggg ctgagaaagg gcaatgagat catgacctta aatggggaag ctgtgtctga     3060

tcttgacctt aagcagatgg aggccctgtt ttctgagaag agcgtcggac tcactctgat     3120

tgcccggcct ccggacacaa aagcaaccct gtgtacatcc tggtcagaca gtgacctgtt     3180

ctccagggac cagaagagtc tgctgccccc tcctaaccag tcccaactgc tggaggaatt     3240

cctggataac tttaaaaaga atacagccaa tgatttcagc aacgtccctg atatcacaac     3300

aggtctgaaa aggagtcaga cagatggcac tctggatcag gtttcccaca gggagaaaat     3360

ggagcagaca ttcaggagtg ctgagcagat cactgcactg tgcaggagtt ttaacgacag     3420

tcaggccaac ggcatggaag gaccgcggga gaatcaggat cctcctccga ggtctctggc     3480

ccgccacctg tctgatgcag accgcctccg caaagtcatc caggagcttg tggacacaga     3540

gaagtcctac gtgaaggatt tgagctgcct ctttgaatta tacttggagc cacttcagaa     3600

tgagaccttt cttacccaag atgagatgga gtcacttttt ggaagtttgc cagagatgct     3660

tgagtttcag aaggtgtttc tggagaccct ggaggatggg atttcagcat catctgactt     3720

taacacccta gaaaccccct cacagtttag aaaattactg ttttcccttg gaggctcttt     3780

cctttattac gcggaccact ttaaactgta cagtggattc tgtgctaacc atatcaaagt     3840

acagaaggtt ctggagcgag ctaaaactga caaagccttc aaggcttttc tggacgcccg     3900

gaaccccacc aagcagcatt cctccacgct ggagtcctac ctcatcaagc cggttcagag     3960

agtgctcaag tacccgctgc tgctcaagga gctggtgtcc ctgacggacc aggagagcga     4020

ggagcactac cacctgacgg aagcactaaa ggcaatggag aaagtagcga gccacatcaa     4080

tgagatgcag aagatctatg aggattatgg gaccgtgttt gaccagctag tagctgagca     4140

gagcggaaca gagaaggagg taacagaact ttcgatggga gagcttctga tgcactctac     4200

ggtttcctgg ttgaatccat ttctgtctct aggaaaagct agaaaggacc ttgagctcac     4260

agtatttgtt tttaagagag ccgtcatact ggtttataaa gaaaactgca aactgaaaaa     4320

gaaattgccc tcgaattccc ggcctgcaca caactctact gacttggacc catttaaatt     4380

ccgctggttg atccccatct ccgcgcttca agtcagactg gggaatccag cagggacaga     4440

aaataattcc atatgggaac tgatccatac gaagtcagaa atagaaggac ggccagaaac     4500

catctttcag ttgtgttgca gtgacagtga aagcaaaacc aacattgtta aggtgattcg     4560

ttctattctg agggagaact tcaggcgtca cataaagtgt gaattaccac tggagaaaac     4620

gtgtaaggat cgcctggtac ctcttaagaa ccgagttcct gtttcggcca aattagcttc     4680

atccaggtct ttaaaagtcc tgaagaattc ctccagcaac gagtggaccg gtgagactgg     4740

caagggaacc ttgctggact ctgacgaggg cagcttgagc agcggcaccc agagcagcgg     4800

ctgccccacg gctgagggca ggcaggactc caagagcact tctcccggga aatacccaca     4860

ccccggcttg gcagattttg ccgacaatct catcaaagag agtgacatcc tgagcgatga     4920

agatgatgac caccgtcaga ctgtgaagca gggcagccct actaaagaca tcgaaattca     4980

gttccagaga ctgaggattt ccgaggaccc agacgttcac cccgaggctg agcagcagcc     5040

tggcccggag tcgggtgagg gtcagaaagg aggagagcag cccaaactgg tccgggggca     5100

cttctgcccc attaaacgaa aagccaacag caccaagagg gacagaggaa ctttgctcaa     5160

ggcgcagatc cgtcaccagt cccttgacag tcagtctgaa aatgccacca tcgacctaaa     5220

ttctgttcta gagcgagaat tcagtgtcca gagtttaaca tctgttgtca gtgaggagtg     5280

tttttatgaa acagagagcc acggaaaatc atagtatgat tcaatccaga tatgggttaa     5340

attcctcatt ttacttttaa actggtggta aagtggaaat tgcaaaaaaa aaaaaaaaaa     5400

aaaactgttc attcctgggt tttgtgcagt atacattttc ccacaaaatg gttgtaaaga     5460

tttaagttat tttaatttat tgtggatcag aaacctagat gaaactggtc agaatctgta     5520

aattacttag tttatatcca ctttgagcag gtatcaaatg atttaggatc cttaaaatta     5580

cattctaata attaagttat gtggaaaaag taaggctggg gaagtcgtga ttaatagttt     5640

tcaaagggcc attttttaaa atcctctggg cattttcttt cagctgtttg ttagtttttg     5700

ctttatttaa agcatattta agttatttta atgtggttta ggggcaaaat gtgcagatac     5760

ttcatttttg taagatagat tgtaatagat gctgtttata ctaaacatgt cataactatc     5820

tatacagtat atattaaaag aaagcttgta ctgtatctta tttgatgata tttattttct     5880

ctgccaagct gtatagtaaa aggaaaataa gtcaca                               5916


<210> 892
<211> 3741
<212> DNA
<213> Homo sapiens

<400> 892
aggcctaagc gcggccgccg tggctcctgc gtctcccatc gtgccgtgcg tcccgcgccg       60

cgttcgagtt ctcggagggg agggggcgtt agccccgcgc agccgccggc gtcgccgcca      120

tggacctagg acccttgaac atctgtgaag aaatgactat tctgcatgga ggcttcttgc      180

tggccgagca gctgttccac cctaaggcac tggcagaatt aacaaagtct gactgggaac      240

gtgttggacg gcccatcgtg gaggccttaa gggagatctc ctcggctgca gcacactccc      300

agccctttgc ctggaagaag aaagccctga tcatcatctg ggccaaggtt ctgcagccgc      360

accccgtgac cccgtccgac acagagacac ggtggcagga agacctgttc ttctcggtgg      420

gcaacatgat ccccaccatc aaccacacca tcctcttcga gctgctcaaa tccctggaag      480

cttctggact ctttatccag ctcctgatgg ccctgcccac caccatctgc catgcagaac      540

tagagcgctt tctggaacat gtgaccgttg acacttctgc cgaagacgtg gccttcttcc      600

tggacgtctg gtgggaggtg atgaagcaca agggtcaccc gcaggacccc ctgctctccc      660

agtttagtgc aatggcccat aagtacctgc ctgccttaga tgagttcccc catcctccaa      720

agaggcttag gtcagaccca gacgcgtgcc ccaccatgcc cctgttggcc atgctgctcc      780

gcgggctgac acagatccag agtcggatcc tgggcccggg gaggaagtgc tgtgcgctgg      840

ccaacctggc tgacatgctg actgtgtttg cgctgacaga ggacgacccc caggaggtgt      900

ctgcaaccgt gtatctggac aaactggcca cggtgatctc tgtgtggaac tcggacaccc      960

agaatcccta ccaccagcag gcgctggcag agaaggtgaa ggaggcagaa cgggatgtca     1020

gcctgacctc gctggccaaa ctccccagtg agaccatttt cgtgggctgc gagttcctgc     1080

accacctgct gcgggagtgg ggggaggagt tgcaggccgt gctccgcagc agccagggga     1140

caagttacga cagctaccgg ctgtgcgaca gtctgacttc cttcagccag aacgcgacgc     1200

tctacctgaa ccgcaccagc ctgtccaagg aggacaggca ggtggtctct gagctggcgg     1260

agtgtgtcag ggacttcctg aggaaaacga gcacggtgct gaagaacagg gccttggagg     1320

atatcacagc ttccattgcc atggccgtca tccagcagaa gatggaccgc catatggaag     1380

tgtgctacat ttttgcctct gagaagaagt gggccttctc ggacgagtgg gtagcctgcc     1440

tggggagtaa cagggccctc ttccgacagc cagacttggt gttgaggctg ctggaaacag     1500

tgatagacgt cagcacagct gacagagcca tccctgagtc tcagatccgg caggtgatcc     1560

acctgatcct ggaatgttac gcagacctct ccctgccagg taaaaataaa gtccttgcag     1620

gtatcctgcg ttcctggggg cgaaagggcc tctctgaaaa gttgctggct tatgtggagg     1680

gttttcagga agacctcaat acaactttta accagctcac tcagagtgcc tccgaacagg     1740

gcttggcaaa agctgtggcc tccgtggccc gcctggtcat agtgcacccg gaagtcacgg     1800

tgaagaaaat gtgcagcctg gctgtggtca atctcggcac ccacaagttc ctggcccaga     1860

ttctcactgc cttccctgcc cttaggtttg tggaagagca gggtcccaat tcatctgcca     1920

ctttcatggt gtcatgcctc aaagaaaccg tctggatgaa gttctctaca cccaaggaag     1980

aaaagcaatt tttagagctc ctgaactgcc tgatgagtcc cgtgaaaccc caagggattc     2040

cagtggctgc tcttcttgag ccagacgagg tgctgaagga atttgtcctg cctttcttga     2100

ggttagatgt tgaagaggta gacctcagtc tgaggatctt catccagact ctagaggcaa     2160

acgcgtgccg agaggaatac tggctccaga cctgctcccc gtttccactc ctcttcagct     2220

tgtgccagct cttggaccgc ttcagcaaat actggcagct tcccaaggag aagcggtgcc     2280

tctctttgga taggaaggat ctagcgatcc atatcctgga gctcctgtgt gagattgtat     2340

cagccaatgc tgagaccttc tccccggatg tctggatcaa gtccctgtcc tggctccacc     2400

gcaagttaga acagctagac tggactgtgg gcctgaggct gaagagcttc ttcgaggggc     2460

acttcaagtg tgaagtgcca gccacacttt ttgagatctg taagctttca gaagacgagt     2520

ggacctccca ggcccaccca gggtacgggg ctggcacggg gctcctggcc tggatggagt     2580

gctgctgcgt ctccagcggc atctcggaga ggatgctgtc tctcttggtg gtggacgtgg     2640

gcaatcctga ggaggtcaga ctgttcagca aaggctttct ggtggccctg gtgcaagtca     2700

tgccttggtg cagccctcag gagtggcagc gccttcacca gctgaccagg agactgctgg     2760

agaagcagct cctccatgtc ccttatagcc tggaatatat tcagtttgtt cccctgctca     2820

acctgaagcc ctttgcccag gagttgcaac tctccgtcct cttcctgagg actttccagt     2880

ttctctgcag ccatagctgt cgtgattggc ttcctctgga aggctggaac cacgtggtca     2940

aactcctctg tggcagtctg acccgcctcc tggactcagt cagggcgata caggcagctg     3000

gcccttgggt tcaaggacca gagcaggacc tgacccagga agccctgttt gtttacaccc     3060

aggtgttctg ccatgctctg cacatcatgg ccatgctcca cccggaggtc tgtgagccac     3120

tctacgtttt agccttggaa accctcacct gctatgagac tttgagcaag accaaccctt     3180

ctgtcagctc cttgctccag agggcacacg agcagcgctt cttaaagtcc attgctgagg     3240

gcatcggccc tgaagaacgg cgccaaaccc tgttgcagaa gatgagcagc ttctgacttg     3300

gcgtggggag ctgggcccca acatggcggg tctgcagaag atcagcagct tcttacctgt     3360

gcgggagcga aaaagctggg cttcaacatg gcaggtctgt aggggtcaga cccgagcagc     3420

ctggacttta cagttatgtg aaactgtcca caaaaagtca tggcaataat ggtgtaaaga     3480

aaatagtttc ttgggtattt gtaacgtaca aactatcata aaaattctcc tctttcgcat     3540

ctcactttgt ctcttctaag tcggcctcag caatagccca ggattaaata tgctctgaaa     3600

ttgggtttag tgtcttcaag atcaaatcca gccaggagga acatgttcat aactggactt     3660

ttccatccta gattttggca aataagccca aagttgaaac catgtgagtg gaaaaagcat     3720

tacatggtac gtataacccc c                                               3741


<210> 893
<211> 768
<212> DNA
<213> Homo sapiens

<400> 893
cctctgcccg ccggcccgtc tgtctacccc cagcatgagc ggcctgcgcg tctacagcac       60

gtcggtcacc ggctcccgcg aaatcaagtc ccagcagagc gaggtgaccc gaatcctgga      120

tgggaagcgc atccaatacc agctagtgga catctcccag gacaacgccc tgagggatga      180

gatgcgagcc ttggcaggca accccaaggc caccccaccc cagattgtca acggggacca      240

gtactgtggg gtatgggctg ggggacgggg gggtgggggg agtgttggaa gaggactcta      300

gccagggtca tatctgccac aaagcacttg ggccccctgc attcaggtga ccacccctcg      360

cctccccttc tccaggacta tgagctcttc gtggaggctg tggaacaaaa cacgctgcag      420

gagttcctga agctggcttg agtcaagcct gtccagagtt cccctgctgg actccatcac      480

cacactcccc ccagccttca cctggccatg aaggaccttt tgaccaactc cctgtcattc      540

ctaacctaac cttagagtcc ctcccccaat gcaggccact tctcctccct cctctctaaa      600

tgtagtcccc tctcctccat ctaaaggcaa cattccttac ccattagtct cagaaattgt      660

cttaagcaac agccccaaat gctggctgcc cccagccaag cattggggcc gccatcctgc      720

ctggcactgg ctgatgggca cctctgttgg ttccatcagc cagagctc                   768


<210> 894
<211> 1050
<212> DNA
<213> Homo sapiens

<400> 894
gacgtcacgt ccggcgcgga gacggtggag tctccgcact gtcggcgggg agctttctct       60

tgcataccct cgcttaggct ggccggggtg tcacttctgc ctccctgccc tccagaccat      120

ggacggctcc ttcgtccagc acagtgtgag ggttctgcag gagctcaaca agcagcggga      180

gaagggccag tactgcgacg ccactctgga cgtggggggc ctggtgttta aggcacactg      240

gagtgtcctt gcctgctgca gtcacttttt ccagagcctc tacggggatg gctcaggggg      300

cagtgtcgtc ctccctgctg gcttcgctga gatctttggc ctcttgttgg actttttcta      360

cactggtcac ctcgctctca cctcagggaa ccgggatcag gtgctcctgg cagccaggga      420

gttgcgagtg ccagaggccg tagagctgtg ccagagcttc aagcccaaaa cttcagtggg      480

acaggcagca ggtggccaga gtgggctggg gccccctgcc tcccagaatg tgaacagcca      540

cgtcaaggag ccggcaggct tggaagaaga ggaagtttcg aggactctgg gtctagtccc      600

cagggatcag gagcccagag gcagtcatag tcctcagagg ccccagctcc attccccagc      660

tcagagtgag ggcccctcct ccctctgtgg gaaactgaag caggccttga agccttgtcc      720

ccttgaggac aagaaacccg aggactgcaa agtgccccca aggcccttag aggctgaagg      780

tgcccagctg cagggcggca gtaatgagtg ggaagtggtg gttcaagtgg aggatgatgg      840

ggatggcgat tacatgtctg agcctgaggc tgtgctgacc aggaggaagt caaatgtaat      900

ccgaaagccc tgtgcagctg agccagccct gagcgcgggc tccctagcag ctgagcctgc      960

tgagaacaga aaaggtacag cggtgccggt cgaatgcccc acatgtcata aaaagttcct     1020

cagcaaatat tatctaaaag tccacaacag                                      1050


<210> 895
<211> 1021
<212> DNA
<213> Homo sapiens

<400> 895
ggcacccccg tccgttccga ctctcgcgag atccctactg gctataaagg cagcgccccg       60

gagagctctt gcgcgtcttg ttcttgcctg gtgtcggtgg ttagtttctg cgacttgtgt      120

tgggactgct gataggaaga tgtcttcagg aaatgctaaa attgggcacc ctgcccccaa      180

cttcaaagcc acagctgtta tgccagatgg tcagtttaaa gatatcagcc tgtctgacta      240

caaaggaaaa tatgttgtgt tcttctttta ccctcttgac ttcacctttg tgtgccccac      300

ggagatcatt gctttcagtg atagggcaga agaatttaag aaactcaact gccaagtgat      360

tggtgcttct gtggattctc acttctgtca tctagcatgg gtcaatacac ctaagaaaca      420

aggaggactg ggacccatga acattccttt ggtatcagac ccgaagcgca ccattgctca      480

ggattatggg gtcttaaagg ctgatgaagg catctcgttc aggggccttt ttatcattga      540

tgataagggt attcttcggc agatcactgt aaatgacctc cctgttggcc gctctgtgga      600

tgagactttg agactagttc aggccttcca gttcactgac aaacatgggg aagtgtgccc      660

agctggctgg aaacctggca gtgataccat caagcctgat gtccaaaaga gcaaagaata      720

tttctccaag cagaagtgag cgctgggctg ttttagtgcc aggctgcggt gggcagccat      780

gagaacaaaa cctcttctgt attttttttt tccattagta aaacacaaga cttcagattc      840

agccgaattg tggtgtctta caaggcaggc ctttcctaca gggggtggag agaccagcct      900

ttcttccttt ggtaggaatg gcctgagttg gcgttgtggg caggctactg gtttgtatga      960

tgtattagta gagcaaccca ttaatctttt gtagtttgta ttaaacttga actgagacct     1020

t                                                                     1021


<210> 896
<211> 1143
<212> DNA
<213> Homo sapiens

<400> 896
atagagaact cccgtaattg gtcggagctc tggaggcggg gcttcgagcg tggctcgtgg       60

gttttccgtg aagtcgcggt gcagcggtgg gcggcatgtc tgtggccggt ggggagattc      120

gtggggacac ggggggagag gacactgctg ctcccggccg gttcagcttc agcccggagc      180

ccacgctcga ggacatccgc cgcctccatg ctgagtttgc tgcggaacga gactgggaac      240

agttccatca gcctcggaat ctcctcctgg ccttggttgg ggaagtgggg gagctggcag      300

aactctttca gtggaaaacc gatggggaac ctggccccca aggctggtcc cccagggaac      360

gggcagccct tcaagaggag cttagtgacg tcctcatcta cctggtggca ttagcagccc      420

gctgccgtgt ggatctgccg ctagcagtgc tctccaaaat ggacatcaac cggcgacgct      480

acccagccca tctggcccgc agctcttccc gcaagtatac agaattgccc catggggcca      540

tctctgaaga ccaggctgtg gggcctgcgg acattccctg tgactccaca ggccagacct      600

caacctagaa agatggccac aggacttgca actcagggtg gtgtctgaag agcagagagt      660

ggcctggccc tggagccttt ttctagtctt ttcagaatag atcatgggcc tgaggcctcc      720

acttcttgag gtctgaggcc cagcagcctc tagaaggtag cctcctggtg tttgttctcc      780

cagtaaaatg gttttgggcg ataacttcta gattattcct ggatggccag ggaggctctc      840

tgtctcagca ggtgatgacg ggggtaccag gggtgcctct gagacccatt ctcgtgtttc      900

cctgttgtac cttttgcctg cagggcagag agatctggtt tctagcaaat tcccagtagg      960

atgtcatgta agttccttcc ccctcttaga gattgaaggc tgtaagagtc cagatggtgg     1020

agccaggctg tctgggttca aatgccatct ttgacacttg caagctaaat gacattactc     1080

aaattaatcg ttctgcactt cagcttcctt gtctatcaaa taaaaagaat agtacctgcc     1140

caa                                                                   1143


<210> 897
<211> 1023
<212> DNA
<213> Homo sapiens

<400> 897
acacaaaggg gtggtcaccc tgccctcacc ttgacctgta agttgcctag gacagtggcc       60

tggtcccagg ggctgttgtg gggagttgaa gaacaccctg gcctcctcca tcatgtcggc      120

caagagggca gaattgaaga aaacacatct gagcaagaac tacaaggcag tttgcctgga      180

attgaagcca gagccgacca aaacatttga ttacaaagca gttaaacaag aagggcggtt      240

taccaaagca ggagtgacac aggacctaaa gaatgaactc agggaagtga gagaagagct      300

caaggagaaa atggaggaga taaaacagat aaaggatcta atggacaagg attttgataa      360

acttcacgaa tttgtggaaa ttatgaagga aatgcagaaa gatatggatg agaagatgga      420

cattttaata aatacacaga agaactataa gcttcccctt agaagagcac caaaggagca      480

gcaggaactc aggctgatgg gaaagactca cagagaacca cagctcaggc ccaagaaaat      540

ggatggagcc agtggagtca atggagcacc ctgtgctctt cacaagaaga cgatggcacc      600

acaaaaaaca aaacagggct cactggatcc ccttcatcac tgtgggacct gctgcgagaa      660

atgtttgttg tgtgctctaa agaacaacta caatcggggg aacattcctt cagaggcctc      720

aggcctttac aaaggtggag aggagccagt gaccacccaa ccttctgtgg gccacgctgt      780

gcctgcccca aagtcccaga ctgagggaag gtgaagctta actgccagct tgaaatgaga      840

gtaaagaaga tacagagcaa acagtgtttc agaaactgtc ctgccctggg tgtgattctt      900

tggcttcaat ttgaaggacg aggaatgatg ggatttcata ttttatttca caccagttcc      960

tccttgtttc atctctttgc taagctggct gcttctacca tctaataaat aattggccaa     1020

gtt                                                                   1023


<210> 898
<211> 2824
<212> DNA
<213> Homo sapiens

<400> 898
cgttcacacc tcctttccga gtatctgcat gccttgctgg cccagagcac aagaccccca       60

ttgtgctccc ccggctcaga atccaaggaa agaaaggaag cgaagcctct gcattgagtt      120

ctaggacagc tgagacactt ggattggact taatcttaaa cctctggagt tcaagacctt      180

ttaaaaaggg ctaaataaac aatctctaca tgtaaaaggc cactgactcc tacttcctct      240

gtatagagca actgttgaac tcagctgcct gtagatagcg gtgggtgtgc tcgcaaacgt      300

gccgccatgt ctgttacgct aacatctgtg aagagagtgc aaagttctcc aaacctattg      360

gctgcagggc gtgattctca gtcaccagac tcagcttgga gatcttacaa tgatggcaat      420

caggagacac tgaacggaga tgctacatat tcctctcttg cagcaaaagg ttttagaagc      480

gttcgaccaa acctacaaga taaaagatca ccaactcaga gccagataac agtgaatgga      540

aactcaggag gtgccgtgag tcccatgagt tactatcaga ggccgttttc cccctcggca      600

tattctctcc cagcctcact caactccagc attgtcatgc agcacggcac atccctcgat      660

tccacagaca catatcccca gcatgcgcag tctctggatg gcaccaccag cagctctatc      720

cccctgtacc gatcctcaga ggaagagaag agagtgacag tcatcaaagc cccgcattac      780

ccagggatcg ggcccgtgga tgaatccgga atccccacag caattagaac gacagtcgac      840

cggcccaagg actggtacaa gacgatgttt aagcaaattc acatggtgca caagccggat      900

gatgacacag acatgtataa tactccttat acatacaatg caggtctgta caacccaccc      960

tacagtgctc agtcacaccc tgctgcaaag acccaaacct acagacctct ttccaaaagc     1020

cactccgaca acagccccaa tgcctttaag gatgcgtcct ccccagtgcc tcccccacat     1080

gttccacctc cagtcccgcc gcttcgacca agagatcggt cttcaacaga aaagcatgac     1140

tgggatcctc cagacagaaa agtggacaca agaaaatttc ggtctgagcc aaggagtatt     1200

tttgaatatg aacctggcaa gtcatcaatt cttcagcatg aaagaccacc ccctctccca     1260

acaactccga cacctgttcc aagggaacct ggccggaagc ctctttctag ctcccgactc     1320

ggagaagtca ctggtagccc ctcccctccg ccccggagtg gcgcccccac accaagctcg     1380

cgcgccccgg ctctgtctcc cacccggcct cctaaaaagc ctctggacta tgttcaagat     1440

cattcttctg gtgttttcaa tgaggcctcc ttgtatcagt cctctataga cagaagcctg     1500

gaaagaccca tgagttctgc aagcatggcc agtgacttca ggaagcggag gaagagcgag     1560

cctgcagtgg gtccaccacg gggcttggga gatcaaagtg cgagcaggac tagcccaggc     1620

cgagtggacc tcccaggatc aagcaccact cttacaaagt ctttcactag ctcttctcct     1680

tcttccccat caagagcaaa agaccgtgag tcccctagaa gttactcatc cactttgact     1740

gacatgggga gaagtgcacc aagggaaaga agaggaactc cagaaaaaga gaaattgcct     1800

gcaaaagctg tttatgattt taaggctcag acatctaagg agttgtcatt taagaaagga     1860

gatactgtct acatcctcag gaaaattgat caaaattggt atgagggaga acaccacggg     1920

agagtgggca tcttcccgat ctcatacgta gagaaactca cacctcctga gaaagcacag     1980

cctgcaagac cacctccgcc agcccagccc ggagaaatcg gagaagctat agccaaatac     2040

aacttcaacg cagacacaaa tgtggagctg tcactgagaa agggagatag agttattctt     2100

cttaaaagag ttgatcaaaa ctggtatgaa ggtaaaatcc caggaaccaa cagacaaggc     2160

atcttccctg tttcctatgt ggaggtcgtc aagaagaaca caaaaggtgc tgaggactac     2220

cctgaccctc caatacccca cagctattct agtgatagga ttcacagctt gagctcaaat     2280

aagccacagc gtcctgtgtt tactcatgaa aatattcaag gtggggggga accgtttcag     2340

gctctgtata actatactcc caggaatgaa gatgagctgg agctcagaga aagtgatgtc     2400

attgatgtca tggaaaagtg tgatgacggc tggtttgtgg ggacctcaag aagaaccaaa     2460

ttctttggta ctttccccgg aaactacgtc aagaggctgt gaattgcgct ccctccttct     2520

gtagaggccg cctgccagcc atgcacctgc gtcaacgcgc ctgaaacacc ccgcgggcct     2580

cccgttgtca tgccttacgg tttccaatgc gccgtcacca tctccacctg ccaccaaacc     2640

accagcagag tagccgccgc tgctgtgagc ctggggacga catggcaggc tggtccccct     2700

ccgtgaaagt gtggattcct acttcctgct ctaagctttg acacgtcaaa atgtgggatc     2760

agaaagaaaa aaatcatgat atttaaaaat ggtcaaatat ttgaggcaaa aaaaaaaaaa     2820

aaaa                                                                  2824


<210> 899
<211> 3036
<212> DNA
<213> Homo sapiens

<400> 899
ccccgctccc aagtgcgcgc ggacccctag ctccctctga gttgcgctgg gcttggctgc       60

tgcaccatga ccctggaggc gatccgctac tcgcggggct ccctgcagat cctagaccag      120

ctgctgctgc ccaagcagag ccgctacgag gcggtgggct cggtgcacca ggcctgggag      180

gccatccgcg ccatgaaggt gcggggcgcc ccggccatag ccctggtggg ctgtctcagc      240

ctcgccgtgg agctgcaggc gggcgccggg ggaccgggac tcgccgcgct cgtggccttc      300

gtgcgcgaca agctgagctt cctcgtcacc gcccggccca ccgctgtcaa catggcccgc      360

gccgcccgcg acctggctga tgttgcagcc cgggaggccg aacgggaggg cgctacggaa      420

gaggcggtcc gggagagacg tgaaacggag ctatgcgagc attgggaaga gcataccagg      480

cagagggaac tgccactgcg agggcccctg ggcgggactg tgctcgagac ccggccctac      540

aaccagggag cccggctgac ggcctttgag ctggtctatg agcagatccc cgccaccctt      600

atcaccgaca gcatggtggc tgctgccatg gcccataggg gcgtgtcagc tgtggtcgtg      660

ggagctgacc gcgtggttgc caacggcgac acagccaaca aggtgggcac ctaccagctg      720

gccattgtcg ccaagcacca tggcattccc ttctacgtgg ctgcccccag ctcttcatgt      780

gacctccgtc tggagaccgg caaggagatc attattgaag agcgaccggg ccaggagctg      840

accgatgtta atggggtccg gattgcagca cctgggattg gagtttggaa tcctgccttc      900

gatgtcaccc cccacgacct catcactggt ggcatcatca cagaactggg ggtctttgcc      960

cctgaggagc tccggacagc cctaaccacc accatctctt ccagggatgg aaccctagat     1020

ggaccccaga tgtaaccaac tcagctctcc ctagcctgcc tctctaggtt tttcaataca     1080

tttcttgaat ggctacccaa aagctgaccg tccagcccct gaccacactt gttcctagtg     1140

cagggagctc agacagggcc ttccatctag agcccagcac ctagagccag gctgcccaga     1200

ttcaaatcct gactccgcca cttttcccac tgtatgatct tgggcaagtc acttcacctc     1260

tctgtgcctt ggtttcctca tttataaaat gtggataaca ggccgggcgc agtggctcac     1320

acctgtaatc ccagcacttt gggaggccga ggcaggtgga tcacaagatc aggagattga     1380

gaccatcctg gctaacatgg tgaaacccca tctctactaa aaatacaaaa aattagccgg     1440

gtgtggtggt gggcacctgc agtcccagct acttgggagg ctgaggcagg agaatggcgt     1500

gaaactggga ggcagagctt gcagtgagcc gagatagcgc cactgcactc cagcctgggc     1560

aacagagcga gactccgtct caaaaataaa tataattaat taattattta attaaaaaaa     1620

taaaaaataa atgtggataa tactagtacc tccctcttaa ggtcagggct ggagctaggg     1680

tgacatctcc agggcagaat tttaagagga caccaaaaaa gctcagcaac caagataaaa     1740

aatattttaa agcaatattt tgttttgggt tttttttttt tgagatcaag tatcactcgt     1800

tacccaggct ggaatgtaga ggcgagatct cagctcactg aaacctgtgc ctccccggtt     1860

caagcgattc tcctgccaca gcctcctgag tagctgggat tacaggcatg cgccaccatg     1920

cccagctaat ttttctattt ttagtagaga catgatttca ccatgttggc caggctggtc     1980

tcgaactcct gactcaaatg atccccctgc ctcagcctcc caaagtgctg ggactacagg     2040

catgagccac tgtgcctgac cttacagcag tattttttaa aaatcaaaat taatgcaaaa     2100

atccatgatg aggccaggct tggtggctca tgcctgtaat tccagcactt tgggaggatc     2160

ccttgagccc aggtgtttga gaccagtttg ggtaacatag gaagagcttg tctctacaaa     2220

caaaaattta aaaacaatga gctgggcatg gaactcacac ctctagcccc agctactcag     2280

gctgaagtgg gaggatggct tgagcccagg agttcaagga tgcagtgtgc tttgattgca     2340

ctactgcact tcaccctaag caacagagtg agaccccatc tctttaaaaa aaaaaaaaaa     2400

tccatgatga acaaaacaag tatttgtttg agacggggtc tcgctctgtc gcccaggctg     2460

gagtacagtg gtgccatctc agctcactgc aacctccgcc ttctgggttc aagcgactct     2520

cctgcctcag cctcccgagt agctgggatt acaggagcct ggcactatgc ctggctaatt     2580

tttgtatttt tattggagac accatgttag tcgtggctgg tctccaactc ctgacctcgg     2640

gtgatccgcg ccccgcggcc tccgaaagtg ctgggattac aagcgtgagc caccgtgccc     2700

ggcctaaata aaattttgaa gaggctagaa ccccgcactt gtgccttgag cttactgacc     2760

tcaacaccct ggttccacta aaactttatt tacaaaatta tgctgccggt ctgcaggatg     2820

tagtttaaca atttgattat tttggatatt aaaatatttt ttaagtcttg aaaatattgt     2880

ttactattac caaagttttt gaaccttctt aaattctgta ccagaggtga gtgccacacc     2940

ctaacctagt ctgagttttt atgtgtaaag atcataaaac gttgtaagtt ttctaaaaca     3000

cataagctct caataaacgt tagcttatca ttgtca                               3036


<210> 900
<211> 6434
<212> DNA
<213> Homo sapiens

<400> 900
gccgcagccg cagccgcagc gacggcagcc acgggagccg ccgcgcatta tgcaaagcgg       60

cggcagatgc gagcggggcc agccgggcgc gcgtcggcct cccctcccag cggctccccc      120

cgccgccgcc tgactctccc gggagactcc ctaggcccgg acctggggcc gaggagggcc      180

gggatggcct gagtgcccgc ggcgcggcgg cgcagcagcg ggattgcacc atggggaacc      240

aggatgggaa gctgaagagg agcgcaggtg atgctttgca cgaaggcggc ggtggcgccg      300

aggatgcgct ggggcccagg gatgtggaag ccacaaagaa ggggagcggg ggcaagaagg      360

cgctaggcaa gcacggcaag gggggagggg gcggcggcgg cggcggggag tcgggcaaga      420

agaagagcaa gtccgactcc agagcctcgg tgttttccaa cctgcggatc aggaagaatc      480

tgtccaaggg gaaaggcgcc ggcggctccc gcgaagatgt actggattcc caggccctgc      540

agaccgggga gctggacagc gctcactccc tgctcaccaa gactccagac ctcagcctct      600

cggcggacga ggccggcctg tcggataccg agtgtgcgga cccttttgag gtgaccggtc      660

cagggggtcc tgggcctgcc gaggctaggg tcgggggccg gccgatcgcc gaggatgtgg      720

aaactgcagc aggggcgcag gatggacaaa ggaccagctc gggctcggac acggacatct      780

atagcttcca ttcggctacg gagcaagagg atttgctttc agacatccag caggcgatcc      840

gcctgcagca gcagcagcag cagcagctcc agctccagct ccagcaacag cagcagcagc      900

agcagctcca gggcgccgag gagcctgcag cgccccccac tgccgtctcc cctcagcccg      960

gggccttcct gggcctggac cggttcctgc tggggccgag cggcggggct ggggaggccc     1020

cgggcagtcc ggacaccgag caggcgctgt ccgcgctctc cgacctgccc gagagcctgg     1080

ccgccgagcc ccgggagccc cagcaaccgc cgtcccccgg cggcctcccg gtctccgagg     1140

cgcccagtct cccggcagcg caacccgcgg ccaaagactc gccctcctcc acggctttcc     1200

catttcccga ggccgggccg ggggaggaag cggccggagc ccccgtgcga ggggctgggg     1260

acacggatga ggagggtgag gaggatgctt ttgaggatgc gccccggggc tctccggggg     1320

aggagtgggc cccggaggtg ggagaggacg ccccgcagag gctgggggaa gagccggagg     1380

aggaggcgca aggacctgac gcccccgcgg ccgcttccct gcccggcagc cccgcgccta     1440

gccagcgctg tttcaagccc tacccgctca tcaccccctg ctacatcaag accaccaccc     1500

ggcagctcag ctcgcccaat cactccccgt ctcagtcccc taatcagagc cccaggatca     1560

agaggcggcc ggaaccctcc ctgagccgag ggtccagaac tgccctggcc tccgtagccg     1620

ccccggccaa gaagcaccgg gccgacggcg gccttgcggc cggcctgagc cgctcggctg     1680

actggacgga ggagctaggc gcccgcacgc cccgggtggg aggctccgcg cacctgctgg     1740

agcgcggggt ggcgagtgac agcggcggtg gggtgtcccc agcactggcc gccaaggcgt     1800

ctggggcccc cgcggctgcg gatggcttcc agaacgtgtt cacagggcga acgctgttgg     1860

agaagctgtt cagccagcag gagaacgggc ctccagaaga agcagagaag ttttgctccc     1920

ggatcattgc catgggtctt ctccttcctt ttagtgattg cttcagggaa ccgtgtaatc     1980

agaatgccca gacgaatgca gcttcgtttg atcaagatca actttatacc tgggctgcag     2040

ttagtcaacc cacacactca ttggactatt cagaagggca gtttcctagg cgagttccat     2100

ccatggggcc accatccaaa cctcccgatg aggaacacag gctcgaggat gctgaaacag     2160

aatctcaatc tgctgtttca gaaactcccc aaaaacgctc agatgctgtc cagaaggaag     2220

ttgttgacat gaagtctgag ggacaggcca ctgtaattca gcagctggaa cagactattg     2280

aggatctgag aaccaaaata gctgaactag agaggcagta tcctgccctg gacacagagg     2340

tggccagtgg tcatcaaggg cttgagaatg gagtgacagc ctcaggcgat gtctgtctcg     2400

aagctctcag gttagaagaa aaggaagtac ggcatcatag gattttagag gcgaaatcga     2460

tacagacttc ccccacggaa gagggcgggg tgctgacact gcctcctgtg gatgggctgc     2520

cagggcgtcc tccatgcccc cctggggctg aaagtggacc tcagacaaag ttctgttcag     2580

agatttcttt gattgtgtct ccaaggcgaa tatcagtcca gctcgacagc catcagccca     2640

cacagagcat ctcacagcct ccaccacctc catcccttct gtggtctgct gggcaaggac     2700

agcctgggtc acagccgccc cattctattt ctaccgagtt tcaaaccagc cacgaacact     2760

ctgtttcctc tgcctttaaa aacagctgta acatcccatc tccaccacct ctgccttgca     2820

cagagtcctc cagctccatg cctggcctgg gcatggtgcc tcccccacct ccccctctcc     2880

ctggcatgac agtgcctact ctgcccagta cagccattcc ccaacctcct cctctgcagg     2940

gtacagaaat gctgccaccc cctccccctc ctcttcccgg agcgggcata cctcctccgc     3000

cgcctctacc cggagcaggc atactccctc tgccccctct acccggagcg ggaatacctc     3060

ctccgccccc tctacccgga gcggcaatac cccctccgcc ccctcttccc ggggcaggca     3120

taccccttcc tccccctctt cccggagcag gaatacctcc tccaccccct ctacccggag     3180

cgggcatacc ccctcctccc ccacttcccg gagcgggcat accccctccg cccccacttc     3240

ccggagcggg cataccccct cctccccctc ttcccggagc gggcatacct cctccacccc     3300

ctctacccgg agcgggcata ccccctccgc ccccacttcc cggagcgggc ataccccctc     3360

cgcccccact tcccggagcg ggcatacccc ctcctccccc tcttcccgga gcgggcatac     3420

ctcctccacc ccctctaccc ggagcgggca taccccctcc gcccccactt cccggagcgg     3480

gcataccccc acctccccct ctacccggag cgggcatacc ccctccgccc cctctacccg     3540

gagtgggcat acctcctccg ccccctctac ccggagcggg cataccccct cctccccctc     3600

tacccggagc gggcataccc cctcctcccc ctcttcccgg agcgggcata cctcctccac     3660

cccctctacc cagagtgggc ataccccctc cgcccccact tcccggagcg ggcatacccc     3720

cacctccccc tctacccgga gcgggcatac cccctccgcc ccctctacct ggagtgggaa     3780

tacctcctcc gccccctcta cctggagtgg gaatacctcc tccgccccct ctacctggtg     3840

ctgggattcc cccacctcct cccttgccag gtatggggat tccacctgct ccagctcccc     3900

cactccctcc acctgggaca ggaatcccac cgccccctct gcttcctgta tcaggccctc     3960

cactcctccc acaagttggg agtagcactt taccaacccc acaggtgtgt ggatttcttc     4020

ctcctccatt gccaagtggc ttgtttggat tagggatgaa tcaggacaaa gggagtagga     4080

agcagcccat agagccttgt cgaccaatga agcctcttta ctggaccagg attcaactac     4140

atagtaaaag agactccagt acttcactta tttgggaaaa aattgaagag ccatccatag     4200

attgtcatga atttgaggaa ttattttcta aaactgctgt aaaggagaga aagaaaccta     4260

tctctgatac tatctcaaag acgaaggcta aacaagttgt caagttatta agcaacaaaa     4320

gatcacaagc agttggaata ctaatgtcta gccttcattt agatatgaaa gacatacaac     4380

atgctgttgt gaacttggat aattctgtgg ttgacctgga gacccttcaa gctctctatg     4440

agaatagagc acagtcagac gaactcgaaa aaatagaaaa gcatggccga tcttccaaag     4500

acaaggaaaa tgccaagtct ctggacaaac ctgaacagtt cctttatgaa ctgtcactaa     4560

tccccaactt ttcagagcga gtcttttgca tcctgttcca gtccacattt tcagaaagca     4620

tttgctcaat tcgtcgcaaa ctggaattac tacagaaatt gtgtgagaca ttaaaaaatg     4680

gcccaggggt tatgcaggtt ctaggtttgg ttcttgcctt tggcaactac atgaatggag     4740

gaaataagac tcgaggacag gcagatggct ttggattaga cattcttcca aaactgaaag     4800

atgtcaagag cagtgacaat agcagaagcc ttttgtcata tattgtttcg tattatctcc     4860

gaaattttga tgaggatgct ggaaaagaac agtgcctctt tccactgcca gaaccccagg     4920

acctttttca ggcctcacag atgaagtttg aagattttca aaaagatctc agaaaactga     4980

agaaagactt gaaagcctgt gaagttgaag cagggaaagt ataccaggtc tcctcaaaag     5040

agcatatgca gcctttcaag gaaaacatgg aacaatttat tattcaagcc aaaattgacc     5100

aagaggcaga ggaaaattca ctgacagaga ctcataaatg ctttttggag accacggcat     5160

atttcttcat gaaaccaaaa cttggagaga aggaggtgtc cccaaatgct ttcttcagta     5220

tctggcatga attcagctct gactttaaag acttctggaa gaaagagaac aaacttcttc     5280

tacaagagag agtaaaagaa gccgaagagg tgtgtagaca gaagaaagga aaatcacttt     5340

ataaaataaa accaagacat gactctggaa ttaaagcaaa gataagcatg aaaacttgaa     5400

caatgaaaag cagaatgaaa atgagtcatt gcaacgactt tcacaaaatt cagctgacct     5460

gagagtggga gggaaactac cgtcattctg ctcatgtttc ttcttgacct cttgcataat     5520

ctttttgttt tctagacagt tcactaattg ttgaatttta ctgtatattc atataaaaat     5580

gcaaacgtac tagaccagtg gagaatttga caccttttct ttttgtaaaa gtttatggta     5640

ttataccgat agaccaaaac agcatgtgta agaggcagta tctgcactaa ttctcaacat     5700

gctaaacatt aactacaatt cactgttgtg agaatattcc tcgtcacagc aaaaacactt     5760

tcctttctac tgacaaccag tcctccacat cacagcattt agacatatgg gtaaaatgtt     5820

atttctagtg aattgtttgt atcagtttca tgtctaagta taaattttct attttaaaat     5880

ttaagaaccg tttataatca gtgctttccc aactcttggg ttgctctcca taactatgta     5940

tttgtgaaag aaaatggtca ttttttttac tgaagtcata taatgacttg ggtcagctcg     6000

taatgcattg tgatggtttt gtatgagctg ggtgtttttt tccattactt ttaatgatct     6060

tcgttgcaag ttatagttgt ggataaaggg gagaatttat tgctcttgca aaccaattat     6120

ggaaagcaac ttaagaaaac caatgttcta aatcataatt gtttgtattt atgtaaagta     6180

tggtctctta ctttttagtt tgtagtttaa gtgcaaagaa acagtagtgg ttttttttct     6240

attgttttgt agtcttcctg tccccttcag tccctccagt gtgtatatta ccattctcca     6300

atgaaataat agggcattta acaaagatcg ctatgtgcaa tactgtattt agtgtttcta     6360

tttcaatttt tctaggatgt taatttatat gaaaataaaa tgaataataa aagaataaag     6420

atacttgcaa aaga                                                       6434


<210> 901
<211> 5219
<212> DNA
<213> Homo sapiens

<400> 901
ctcgcgcggc ttcccgcttc cggctcccag ctgctagcta ctgtggatct gggggggccg       60

gacggaggca tcggaggcgg ctgcgagagt ggcagaggag ctggcggaga gcggcctgcg      120

ggcgatcggg ccgagcctcg ctcaaggagc acccccgggg caccctcctg tccgatggca      180

gcccggccct gtccaggaat gtcggtatga cggtctctca gaaagggggt ccccagccaa      240

caccgagccc ggctggccct gggacgcaac tcggaccaat cacaggagag atggatgaag      300

ccgattctgc gtttttaaaa tttaagcaga cagctgatga ctctctgtcc cttacatctc      360

caaacaccga gtccattttt gtagaagatc cctacaccgc ctcgctgagg agtgagattg      420

agtcagacgg ccacgagttt gaagctgagt cctggagcct cgccgtggat gcagcctacg      480

ccaagaagca aaagagggag gtggtgaaaa gacaagatgt cctttatgag ctgatgcaga      540

cagaggtgca ccacgtgcgg acgctcaaga tcatgctgaa ggtgtactcc agggccctgc      600

aggaggagct gcagttcagc agcaaggcca ttggccgcct cttcccatgc gctgacgacc      660

tgctggagac gcacagccac ttcctcgctc ggctcaagga gcgccgccag gagtccctgg      720

aggagggcag tgaccggaat tatgtcatcc agaaaatcgg cgacctcctg gttcagcagt      780

tttcaggtga aaatggggag agaatgaaag aaaagtacgg tgtgttttgt agtggccaca      840

atgaagctgt tagtcattac aagttgctgc ttcagcaaaa caagaaattt caaaacttga      900

tcaagaaaat tggcaacttc tccatcgtgc ggcggcttgg cgtgcaggag tgcattctcc      960

tggttacaca acgcataacc aaatacccag tgctggtgga gcgcatcatc cagaacacgg     1020

aagctggcac tgaggactat gaagacctga cccaggcctt gaacctcatc aaagatatca     1080

tctcacaagt ggacgccaag gtcagtgagt gtgagaaggg ccagcgcctc agggagatcg     1140

cagggaagat ggacctgaag tcttccagca aactcaagaa cgggctcacc ttccgcaagg     1200

aagacatgct tcagcggcag ctccacctgg agggcatgct atgctggaag accacatcag     1260

ggcgcttgaa agatatcctg gctatcctgc tgaccgacgt acttttgctg ctacaagaaa     1320

aagatcagaa atacgtcttt gcttctgtgg actcaaagcc acccgtcatc tcgttacaaa     1380

agctcatcgt gagggaagtg gccaacgagg agaaagcgat gtttctgatc agcgcctcct     1440

tgcaagggcc ggagatgtat gaaatctaca cgagctccaa agaggacagg aacgcctgga     1500

tggcccacat ccaaagggct gtggagagct gccctgacga ggaggagggg cccttcagcc     1560

tgcccgaaga ggaaaggaag gtggtcgagg cccgcgccac gagactccgg gactttcaag     1620

agcggttgag catgaaagac cagctgatcg cacagagcct cctagagaaa cagcagatct     1680

acctggagat ggccgagatg ggcggcctcg aagacctgcc ccagccccga ggcctattcc     1740

gtggagggga cccatccgag accctgcagg gggagctaat tctcaagtcg gccatgagcg     1800

agatcgaggg catccagagc ctgatctgca ggcagctggg cagcgccaac ggccaggcgg     1860

aagacggagg cagctccaca ggcccgccca ggagggctga gaccttcgcg ggctacgact     1920

gcacaaacag ccccaccaag aatggcagtt tcaagaagaa agtcagcagc actgacccca     1980

ggccccgaga ctggcgaggc cccccaaaca gcccggactt gaagctcagt gacagtgaca     2040

ttcctgggag ctctgaggaa tcgccgcagg tggtggaggc gccaggcacg gaatccgatc     2100

cccgtctgcc caccgtcctg gagtcggagc ttgtccagcg gatccagaca ctgtcccagc     2160

tgctcctgaa ccttcaggcg gtaatcgccc accaggacag ctatgtggag acgcagcggg     2220

ctgccatcca ggagcgggag aagcagttcc ggctgcagtc gacgcgtggg aacctgctgc     2280

tggagcagga gcggcaacgc aacttcgaga agcagcggga ggagcgcgcg gccctggaga     2340

agctgcagag ccagctgcgg cacgagcagc agcgctggga gcgcgagcgc cagtggcagc     2400

accaggagct ggagcgtgcg ggcgcgcggc tgcaggagcg cgagggcgag gcgcggcagc     2460

tacgcgagcg gctggagcag gagcgggccg agctggagcg ccagcgccag gcctaccagc     2520

acgacctgga gcggctgcgc gaggcccagc gtgccgtgga gcgcgagcgg gagcgcctgg     2580

agctgctgcg ccgcctcaag aagcagaaca ccgcgccagg cgcgctgccg cccgacacac     2640

tggccgaggc ccagccccca agccaccctc ccagcttcaa cggggaaggg ctggagggcc     2700

ctcgtgtgag catgctgcca tccggcgtgg ggccagagta cgcagagcgc cccgaggtgg     2760

ctcgccggga cagcgccccc accgagaacc ggctggccaa gagcgatgtg cccatccagc     2820

tgctcagcgc caccaaccag ttccagaggc aggcggccgt gcagcagcag atccccacca     2880

agctggcggc ctccaccaag ggtggcaagg acaagggcgg caagagcagg ggctctcagc     2940

gctgggagag ctcagcgtcc ttcgacctga agcagcagct gctgctcaac aagctcatgg     3000

ggaaagatga gagcacctca cggaaccgcc gctcgctgag ccctatcctg cccggcagac     3060

acagtcctgc gcccccacca gaccctggct tccccgcccc gagcccaccg ccagctgaca     3120

gcccctccga gggcttctct ctcaaggccg ggggcacagc cctcctgccc gggcccccag     3180

ctccctcgcc actgccggcc acaccactca gcgccaagga ggacgccagc aaagaagacg     3240

tcatcttctt ctaaaagggc cgtgactcaa ggaaagtttt taatggaaag ttgagccaga     3300

actaaaccag ggagctgtct gaaatcatag caccccatcc gggtggcggg gagatcaact     3360

ccgagctgtt tttccgaggc agtgaggaac ggtgccggct ctgcacggag ctgaggacag     3420

gacagacctt gctttgagaa ggagctgccg gccggggcca cgctccacag ccgccgcgcg     3480

acagtggagc caagggttag ggcaccagga ggggccaggt ggcgtcggca gcatctgtcc     3540

ccagaatcag gcagaatcca cttcccaaac agagccccac gcaggttcac catgaacctc     3600

agggtcaggg aatgagccag gcacgggggc atgggcagag agggccacgg ggcagggccc     3660

actgagggaa catcagtggc cctccagtca ggttctgtgg gtttggaagc ccatcgtgaa     3720

aggggctgac ctttgcccct ttttacttgg cattggtttt gaaaccagct gtttcccaaa     3780

ctctgcttcc caagggcaac cgttgctgtt cacacgctca gcctgtctgg gggagcgggc     3840

ctctagcttc agccagggcg ggtacacacc ctgggcacag ggtcctcagc ccccgggaaa     3900

tgagctccca gggctggcgt cccaccttcc aggtgggggc tggcacatca cagactgtcg     3960

agagcgccat gtcccagggc atgcagagga tgcacctaga gacgttgcag caagtggaca     4020

agtggccgct gtgcgggccc ctcgcttgta gtgagctgtt gcagcttacg gtccgttccc     4080

tggaggggtg gaggaaggag gtgttgggca gcatcaaagg tgctgggaca tcccagggtg     4140

gtgagatcca tccacgatcc agctccggtg gagaaagggc ccatgtcaag ccttgttctg     4200

caccccaagc attggtggta ggactgggtc ctggctgatc gtccttgttc ccagtggggt     4260

acatgtgagc ccctgccagg gccaagtcct tctcccgaac ccagggtcct gggaactgca     4320

gatcccgggg ggattcagcc cttctcccac tgtgctggca gaggcactcc tgtgacgctg     4380

aatacagtga acagggacat tcccgccact cggggacaga tgggcacaag ggaggggaaa     4440

ctccatcagg aagtgctccc ctgggcagag gcgcccactg ggtgctgtgg gctcaggagg     4500

gggcggggca ggagctggtg ccaaccggga accagagccc cacagccata cagcccattg     4560

gtgacaaggt cctgagaaca cagtggccag gtgtccccag gctcctggcc cctccgacga     4620

cctcaactct gcccagcccg gtccctggcc atcagcgacg ctgtccgccc cccgtcagat     4680

cccatgtgtg ccatgtttat catcagtgtt ttgtattttt gtactgagta tcggagcact     4740

ttacagaagc tgactgtaca ttcctgttct gttgtgaaga gaacattccc agaccctggc     4800

accctcctga gccggcgtgt gccggtccag ccctccgaga tgccacaatt ccttggatgg     4860

gggagaagtt caaggaattt ctgctcggcc acgcggtggg aaccccgcgt ccccgccatg     4920

tggcagaggg gtctcagtcg tgctaggcat cgggcggcag cgccgacagc ccttccctcg     4980

ccagtgcccc tcggccactc ctgggttgga gcccgatttt atttgtaaag ttgacagtcg     5040

agcaaatgtt cctattttcg tgggatctgc acacgtcttt gtcagttgtg gtcatgatct     5100

tagtcacctg ctaattattt ttacaatgat tacaacattt cctcactgcg ggatatttct     5160

gacccgcttt agaacttaag acctgattct agcaataaac gtgtccgaga tgagcggtg      5219


<210> 902
<211> 3190
<212> DNA
<213> Homo sapiens

<400> 902
agcgcttgtg acggtgtgac cagggagggg aagtgtaagt gtctggccgt ccgtggtggc       60

ggggccagca ggctgtccca gccctcaccc ggagctcctc acccggcacc acatctgtgt      120

tttcccagga cccacgcagc cacccagcct cagcactcat ctgcgcagcc atggaggccc      180

tgggacctgg gggcgaccgc gcctccccgg cctcgtccac tagcagcctg gacctgtggc      240

atctgtccat gcgcgcggac tcggcctaca gctctttctc cgcagcctcc ggcggccccg      300

agccgcgcac gcagtcgccg gggacagacc tccttcctta cctagactgg gactacgtgc      360

gtgtggtttg gggcggcccg ggccccgccc cgcccgacgc tgccctttgc acatccccgc      420

ggccccggcc cgcggttgca gcccgcagtg ggccgcagcc aacagaggtc ccggggaccc      480

cgggaccact gaacaggcag gccaccccgc tgctgtacgc gctggcggcc gaggcggagg      540

ccgcggcgca ggctgccgag ccgcccagcc cgccggcctc gagggccgcc taccgccagc      600

ggcttcaggg cgcgcagcgg cgagtgctcc gggagacgtc gttccagcgc aaggagctcc      660

gcatgagcct gcccgcccgt ctgcggccca ctgtcccagc gcggcccccg gcgactcacc      720

cgcgctccgc ctcgctcagc cacccgggcg gggaggggga gccggcgcgc tcccgggctc      780

ccgcgccagg aactgccggc cggggtcccc tcgccaacca gcagcggaag tggtgcttct      840

cagagccagg aaagctggat cgtgtgggtc ggggcggtgg gccggcgcgg gaatgcctgg      900

gtgaggcctg ctccagctct ggcctccctg ggcccgagcc cttggagttc cagcatccgg      960

cgctggctaa gtttgaagat cacgaggtcg gatggctgcc cgagacgcaa ccccaaggct     1020

ccatgaacct ggactccggg tccttgaagc tcggtgatgc cttcaggccc gccagtcgga     1080

gtcggagcgc ttcaggcgaa gtcttgggtt cctggggagg atcaggaggg accataccca     1140

ttgtccaggc tgttccccaa ggagcagaaa cccccagacc attgtttcag accaaacttt     1200

ccaggttctt gcctcagaaa gaggctgcgg tgatgtatcc tgcagagtta ccccagagca     1260

gccctgctga cagtgaacag agggtctcag agacctgcat tgtgcctgcc tggctcccct     1320

cccttcctga tgaagtgttc ctagaagagg ccccactggt cagaatgaga tcaccaccag     1380

acccccatgc ctcccagggg cccccagcca gtgtccatgc ctctgaccag ccgtatggaa     1440

ctggcttagg ccaaagaact ggccaggtta cagtccccac agagtacccg ctccatgagt     1500

gtccaggaac tgcaggggca gatgactgct ggcagggggt gaatggttct gtaggtattt     1560

ccaggcccac aagccacacc cccactggga ctgcaaatga taacatccca actattgacc     1620

ccactggact gaccaccaat ccccccacag ctgcagagag tgacctcctc aaacctgtcc     1680

cagctgatgc cttgggactt tcaggcaatg atactccagg tccctctcac aatactgccc     1740

tagccagggg cactggccag cctggttcca ggcccacatg gcctagtcag tgcctcgagg     1800

agctggttca ggagctggcc agattagatc cctctctatg tgaccctctt gcttcccagc     1860

ccagcccaga gccacccctg ggcctgctgg atggactgat tcctttagca gaggtccggg     1920

ctgcaatgcg gcctgcctgt ggggaggctg gagaggaggc tgccagtact tttgagccag     1980

ggtcctatca gttcagcttc acccagctcc tgccggctcc tcgggaggag acaaggcttg     2040

aaaaccctgc cacccaccct gtgcttgacc agccatgtgg gcaggggctc cctgcaccaa     2100

acaacagcat ccagggcaag aaagtggagc tggccgcccg cctccaaaag atgcttcagg     2160

accttcacac ggagcaggag cggctgcagg gggaggcaca agcgtgggcc aggcgccaag     2220

cggctctgga ggctgcagtg cgccaggcct gtgcccctca ggagctggag cggttcagcc     2280

ggttcatggc cgacctagag cgcgtgcttg gccttctgct gctgctgggc agtcgcctgg     2340

cgcgcgtgcg ccgcgccctg gcccgggcgg cctcagacag cgaccctgat gagcagcgac     2400

tccggctcct gcagcggcag gaggaggacg ccaaggagct gaaggagcac gtagcgcggc     2460

gcgagcgggc cgtgcgggag gtgctggtgc gagcactacc ggtggaggag ctgcgcgtct     2520

attgcgccct gctggcgggc aaggccgccg tcctggccca gcagcgcaac ctggacgagc     2580

gcatccgcct ccttcaggac caactggacg ccatcaggga cgaccttggc catcatgccc     2640

cgtctcccag cccggcgcgg cccccaggga cctgtcctcc agttcagccg cccttccctc     2700

ttctccttac atagttatag gtggagaggg tggggtgcac cgcccctatc tctcacccac     2760

gtaagtgggg tgatgctgat ttagtctctg cttttccctt gagggattgg ggaggaccca     2820

gtccaggcct ttctaagata ctcctccagc cgggcgcggt ggctcacgcc tgtaatccca     2880

gcactttggg aggccgaggc gggcggatca caaggtcagg agatcgagac catcctggct     2940

aacacggtga aaccccgtct ctactaaaaa tataaaaaat tagccgggcg tggtggcggg     3000

tgcctgtatt gccagctact cggaaggctg aggcaggaga atggcgtgaa cctgggaggt     3060

ggagcttgca gtgagcggac atcgcgccac tgcactccag cctgggcgac agagcaagac     3120

tccgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaga tacttctcca aagtgttctc     3180

atgtggcctc                                                            3190


<210> 903
<211> 3018
<212> DNA
<213> Homo sapiens

<400> 903
ggactgtggg agcggcttcc ttggattccg cgcttggcaa cggctcggcg tcgcgctttg       60

gccaaccgct gcgtcgtccc tgggcccgaa taactgtcgc ccgcttccct cagcgtgagg      120

tgaagcactt caaattgcct gatgaaagtt gaatcaggaa tgaagataaa agtacacaac      180

aatgcagaaa gcggtactta gcctcacaaa gatggaaaca ttccaaaaac gtgaaaaact      240

gcagtaggct tcttggaagt agaccaaggg tgtccaatct ttggcttccc tgggccacat      300

cggaagaaga attgtcttgg gccacacatg aaattcacaa acactaaggt acaaatgatg      360

caaaatgtgc acctggctcc agagacagat gaagatgatc tttattccgg ctataatgac      420

tacaatccaa tctatgatat cgaggaattg gagaatgatg cagcttttca gcaagctgtg      480

aggactagtc atggcagaag acctccaata actgctaaaa tatcaagcac ggcagttact      540

agacctatag ctactggata tgggtccaag acatctctgg catcatcaat aggaagacca      600

atgacagggg ctattcagga tggagttact agacccatga cagcagtgag agcagctggt      660

tttaccaaag cagctttgag aggctctgca tttgaccccc ttagtcagtc aaggggccct      720

gcttcccctt tggaagccaa gaaaaaagat agcccagagg aaaaaataaa gcaattagag      780

aaggaagtaa atgagttggt agaagaaagc tgtattgcca atagttgtgg agacttaaaa      840

ttggccttag aaaaggcaaa agatgcagga agaaaagaga gagtcctggt gagacagcga      900

gaacaagtta caactccaga aaatatcaat ttggatttaa cttactcagt tcttttcaat      960

ttggccagtc agtattcagt taatgaaatg tatgccgaag cacttaacac ttatcaagtt     1020

atagtcaaaa ataagatgtt tagcaatgca ggaatattga aaatgaatat gggaaatatc     1080

tatttaaagc aaagaaatta ttccaaagcc attaaattct accgaatggc attagaccaa     1140

gttccaagtg tcaataagca aatgaggatt aaaataatgc agaatattgg agttacattt     1200

attcaggctg gtcagtattc agatgctatt aattcatatg agcacataat gagcatggca     1260

ccaaatctga aggcaggcta caacctaact atctgttatt ttgctattgg agaccgagaa     1320

aaaatgaaga aggcattcca aaaattgatt actgttccat tagaaattga tgaagataaa     1380

tatatttcac caagtgatga tcctcatact aacttagtaa ctgaagctat aaaaaatgat     1440

cacctcaggc aaatggaacg tgaaaggaaa gccatggcag aaaaatatat tatgacatct     1500

gcaaaactca ttgctcctgt aattgaaaca tcttttgctg caggttatga ttggtgcgtg     1560

gaagtggtga aagcttctca atatgtagag ctagccaatg atctggaaat aaacaaagca     1620

gttacatact tgagacaaaa agactataac caagctgtag agatcttaaa agtgttggaa     1680

aaaaaggaca gtagagtgaa aagtgcagct gcaaccaatc tctcagccct gtattatatg     1740

ggaaaggatt ttgcacaagc cagcagctat gcagatatag ctgtgaactc tgatagatat     1800

aatccagcag ctcttactaa taaagggaat acagtttttg caaatggtga ttatgagaag     1860

gccgctgaat tctataaaga ggctctaaga aatgattctt cttgtactga agcactttat     1920

aatattggcc ttacctatga gaaactaaat cggctagatg aggctttgga ctgtttcctg     1980

aaacttcacg caatcctacg aaacagtgcc gaagttcttt accagatagc aaatatatat     2040

gaattaatgg aaaatcccag tcaagctatt gaatggctaa tgcaggtggt cagtgttatt     2100

ccaaccgatc ctcaagtttt atctaagcta ggagaattat atgatcgtga aggagataaa     2160

tctcaagcat ttcaatatta ctatgagtca tataggtatt ttccttgtaa tattgaagtc     2220

attgagtggc ttggagccta ttacattgac acccaatttt gggaaaaagc tattcagtac     2280

tttgaaagag cttctcttat acagcctaca caagtgaaat ggcagctgat ggtagctagt     2340

tgtttcagaa gaagtggtaa ctaccaaaaa gcattagata cttacaaaga tactcacaga     2400

aaatttccag aaaatgtcga atgtctgcgt ttcttagttc gtctctgcac agatcttgga     2460

ttaaaagatg ctcaagaata tgccagaaaa ctgaagaggt tggaaaaaat gaaagaaata     2520

agggaacagc gcataaagtc aggcagagat ggcagtgggg gctcccgtgg caaaagagaa     2580

ggaagtgcta gcggtgatag tggccagaac tatagtgcca gtagtaaagg tgaacgacta     2640

agtgccagac tcagagcttt acctgggaca aatgaacctt atgaaagtag cagtaacaaa     2700

gaaatagatg cctcctatgt ggacccactt ggccctcaaa tagaacgacc aaaaactgca     2760

gccaagaaaa ggatcgatga ggatgatttt gctgatgaag aattaggaga tgatttgctt     2820

ccagaataat attcacttta atatttatta aaggaaagaa attgccttat gagatcatcc     2880

tcatgttaaa ccttggatta aatatctaac ctgtaattat tttttttcac tgtcaaaact     2940

taagtaagtg tattctattc tgtatgtatg catttaagtt gtttttttct tttaaggaat     3000

aaaaacaggt aaaactaa                                                   3018


<210> 904
<211> 2207
<212> DNA
<213> Homo sapiens

<400> 904
ccgcgccgga ggacgagcct cggtcatcgc gctgccctcc caggttcaac aggctaccca       60

tgtgcccgct ccagtaagcg tgcaaccagc ccggtcagtc ccagggactt taccggctag      120

gagacacctt gaacgtcccc agcgcgactc ccacaaactg ccttgactct ttaacgcttc      180

ctcgctggcg cccattgggc caggcgttta cgtcatcgct gcgcgccggg cggcggcgac      240

ttcccgctcc ttgactctga cgtcagagcg gcgccggcct cggcggctga ggaaagcagg      300

aggaggtggc ggcggcggga agatgctgct ctttggcgta aattgcaatc gattagggat      360

cgtttctcag aatcaagtta gaagtgagag ttcagataag tgaggccgcc attgctgctt      420

tgaacacctc agaaggggag aatggattta tcaggagtga aaaagaagag cttgctagga      480

gtcaaagaaa ataataaaaa gtccagcact agggctcctt cacctaccaa acgcaaagac      540

cgctcagatg agaagtccaa ggatcgctca aaagataaag gggccaccaa ggagtcgagt      600

gagaaggatc gcggccggga caaaacccga aagaggcgca gcgcttccag tggtagcagc      660

agtaccaggt ctcggtccag ctcgacttcc agctcaggct ccagcaccag cactggctca      720

agcagtggct ccagctcttc ctcagcatcc agccgctcag gaagctccag cacctcccgc      780

agctccagct ctagcagctc ttctggctct ccaagtcctt ctcggcgcag acacgacaac      840

aggaggcgct cccgctccaa atccaaacca cctaaaagag atgaaaagga gaggaaaagg      900

cggagcccat ctcctaagcc caccaaagtg cacattggga gactcacccg gaatgtgaca      960

aaggatcaca tcatggagat attttccacc tatgggaaaa ttaaaatgat tgacatgccc     1020

gtggaaagga tgcatcccca tctgtccaaa ggctatgcgt acgtagagtt tgagaatcca     1080

gatgaagccg agaaggcgct gaagcacatg gatggaggac aaattgatgg ccaggagatc     1140

actgccaccg ccgtgctggc cccctggcct aggccacccc ccaggagatt cagccctccc     1200

aggagaatgt tgccaccacc gcctatgtgg cgcaggtctc ccccacggat gaggagaagg     1260

tcccgctccc cgaggcgcag gtcccccgtg cgccggagat cacggtcccc gggccgccgc     1320

cgccacagga gccgctccag ctccaactcc tcccgataaa caggccactg aagctctcgc     1380

ccctgtaact tataccccac ccagctcagt tttgtcactt ttctagccaa aggaagacca     1440

gtaggaaagc aaacccttga ctctggcagg atttgcaggc agcaggcagc acccctctgc     1500

cagccgggcc ccggctgcag aagtgctgtt ggtttggatg ctgtgtgcct gtcaagattc     1560

cctccggttt tctggctaga aagctcatcc gtttccggtt tctaagagtc agttcagtgg     1620

cagagccacc agggaaaagt gaggctcttg ggggtggttt gaccctgctt acctgggagc     1680

acacttttcc cttccccgat gacctgggat ggtggccagg ccgtgccctt gctgttgctg     1740

ggcagtgtcc ttttggaaag ggagctgccc caggctttag tgcagctgcc aaccctgtta     1800

ggcctggcct ctcgaggcct cttctgacct caagggtcac accccctcaa agatcctctc     1860

acccatggta gttgctgctc gtggttctgt ctgtccgtgc accgatgcac acaccgcacc     1920

ccaccactgt actctgaaat tggcgagtga gtggagagcc agctctgcgg agtcatcacg     1980

cagccatggt tgtgcctgcc gttcatggtg gtctttcagg ttatcttggc aacatgtaca     2040

ttgcttttat tttttttctt ttttgctttc attgtacagt cagtactata aaatttctct     2100

tttgagtttt atacctttgt agcattttag atgacattgt gtttgtactt tgttgtgtag     2160

agtggaagaa ttgtgttgaa taaacccaag atcggaatgc aaatcta                   2207


<210> 905
<211> 2818
<212> DNA
<213> Homo sapiens

<400> 905
ggtgcgcgga gggcgcgtct ctgacggaag ccggggcgga cggtcggagt ccggaagaaa       60

aacagtccgc gacagctagg cgcgtgagac cggccgcccg cagggctgct ctggccggga      120

cccgctggcc gggagacgcg aacctgccgg accaccgcgc ggggacgacg gcggccatga      180

gctcgcggaa gctgagcggg ccgaaaggca ggaggctcag catacatcag gaggtctgcc      240

tgatcccatg gtgaaccccg ggaatccgaa atcagattga gataagatcc tttagggaag      300

tgacttagcc tggtctcttg cctgctcttt cacggggaac aacgctaatc gcccacttag      360

tctaagtcac gatgcttgga tttgctgcta atcgtcggat ttgagagtgg gaacaagaaa      420

tccggacttt tgctctccat cctcttagac atacacgtcg tgacttggaa cgtggcttcg      480

gcagcgcccc ctctagatct cagtgacctg cttcagctga acaaccggaa cctcaatctt      540

gacatatatg ttattggttt gcaggaattg aactctggga tcataagcct cctttccgat      600

gctgccttta atgactcgtg gagcagtttc ctcatggatg tgctttcccc tctgagcttc      660

atcaaggtct cccatgtccg tatgcagggg atcctcttac tggtctttgc caagtatcag      720

catttgccct atatccagat tctgtctact aaatccaccc ccactggcct gtttgggtac      780

tgggggaaca aaggtggagt caacatctgc ctgaagcttt atggctacta tgtcagcatc      840

atcaactgcc acctgcctcc ccacatttcc aacaattacc agcggctgga gcactttgac      900

cggatcctgg agatgcagaa ttgtgagggg cgagacatcc caaacatcct ggaccacgac      960

ctcattatct ggtttggaga catgaacttt cggatcgagg actttgggtt gcactttgtt     1020

cgggaatcca ttaaaaatcg gtgctacggt ggcctgtggg agaaggacca gctcagcatt     1080

gccaagaaac atgacccgct gctccgggag ttccaggagg gccgcctact cttcccgccc     1140

acctacaagt ttgataggaa ctccaacgac tatgacacca gtgagaaaaa acgcaagcct     1200

gcatggaccg atcgcatcct gtggaggctg aagcggcagc cctgtgctgg ccccgacact     1260

cccataccgc cggcgtcaca cttctccttg tctctgaggg gctacagcag ccacatgacg     1320

tacggcatca gcgaccacaa gcctgtctcc ggcacgttcg acttggagct gaagccattg     1380

gtgtctgctc cgctgatcgt cctgatgccc gaggacctgt ggaccgtgga aaatgacatg     1440

atggtcagct actcttcaac ctcggacttc cccagcagcc cgtgggactg gattggactg     1500

tacaaggtgg ggctgcggga cgttaatgac tacgtgtcct atgcctgggt cggggacagc     1560

aaggtctcct gcagcgacaa cctgaaccag gtttacatcg acatcagcaa tatccctacc     1620

actgaagatg agtttctcct ctgttactac agcaacagtc tgcgttctgt ggtggggata     1680

agcagaccct tccagatccc gcctggctcc ttgagggagg acccactggg tgaagcacag     1740

ccacagatct gagccaggat gggagtgaat cccaggcgga ggccagagct ggcagccagc     1800

tctgcctttc cactgccggg agtgctgggg gcccagcctg gccccctgaa gagacagcca     1860

agtgtcgtcc acatactcct cccagagtga gctctaacca ggctcatttg ctctctccac     1920

tactcatctc tggaattagc cgcttaaata caggtttttg ttgctgagat gtgagtgaaa     1980

ccagctagtg tgtcaacagt gaagacctgg ggacagttct gcgtctcatt tctggattcc     2040

taccccctct tctagtcttg cccaagtagt cctgccaggc acatgcccca tttggcacag     2100

gcctgcattc ttgtcgtgcc gtcctgggcc tcaggctgtc tgggagggga gatgctcaca     2160

tttgtacagg ctacatagac tggtgcaagc agtgctggat tccaggagtc ttggcatctc     2220

atagcttgtc cccgtgagga gtgagcagag ggtctgggat ttctgctttc agcaaaagca     2280

gtctgactca gtgggcagaa tggaggggcc cctctagcca ggctcttacg ccatggttat     2340

gagcaggttg atgagggtcc ttcggccagc acaaccttcc tccctactca cggcatggag     2400

tctgactgca tggaagttcc agatcctgac agagagaact gggaaggatc caggttcgct     2460

tccgttggta gcttgagtcc catgcctcca ccctgccatc tgaggaaggg gtgacaagtg     2520

gtcaaggagc tgtggccaca gacttttcca gggtggtcct tggcaggtga ggtgcgtctg     2580

tgccaccctt gtcaggagcc attgacgacg ggccccccct ggaccccccg ggacctcaga     2640

gtgggggcag gcagaaggga gaaccagctc aagacatttt ggaggatctg gccctggggt     2700

tcttcagaga acaccctcta ggggctttgg ggacatggcc tgtccccaca tccagcactt     2760

gcctccgcca tggtcactcg gcagcccttt tcccaggaga agacacctct gggagcct       2818


<210> 906
<211> 2389
<212> DNA
<213> Homo sapiens

<400> 906
cacaagctct agagggcttc cgggaggagg cttagggagc tgggaatccg ggagcagatg       60

gtgggttcct accgtcgagg gtgggagaga gggatctgag gccaagtttg aggtaaggac      120

tgtggagctc catcagatcc ccatccccac ctcccctcat ctgcgcaatc ctgcgagaag      180

ccttagacag gttctggctc agagaaccgg agagaggcac aacgcctggc ccccaggact      240

tggccacagc gtccctgacc ttgtctgctc catgacctct cactgaggcc cattaacccc      300

tcagttccct gatgaggctt gatttagcat ccttgatgtc agctcctaag agtctgggaa      360

gtgcatttaa gtcctggagg ttggacaagg ccccctcccc acagcacacc tttccatcca      420

cttctatccc aggcatggct tttgctctcc tggcctccgt gcccccggtg tttggactct      480

acacttcttt cttccccgtc ctcatctaca gcttgctagg tactgggaga cacctgtcca      540

caggaacttt cgccatactc agcctcatga caggctcggc cgtcgagcgg ctggtgccgg      600

aacccctcgt ggggaatctg agcggaatcg agaaggagca gctggacgct caacgggttg      660

gggtagccgc ggccgtggcc ttcgggagcg gggcgttgat gctggggatg ttcgtgctgc      720

agctcggcgt cttgtccacc tttttgtccg agcctgtggt caaggcgctg accagcgggg      780

ccgcgctgca cgtgctcttg tcccagctgc cgagcctctt ggggttgtcc ctcccgcgcc      840

agatcggctg cttctctctc ttcaagacgc tggcctcctt gctgactgcg ctgcctcgga      900

gcagtccggc cgaactgacc atctccgcgc tcagcctggc gctgctcgtg ccggtcaagg      960

aattgaacgt gagattccga gaccggctac ccacgccgat cccgggggaa gtcgtcttgg     1020

tgcttctggc ctccgtgctc tgcttcacct cttctgtgga cacaagatac caagtccaga     1080

tagtggggct gttgcctgga ggatttcccc aacccctcct ccccaacctg gctgagctgc     1140

ccaggattct ggctgactcg ctgcccattg cactggttag ttttgcggtg tctgcctccc     1200

tggcctccat ccatgcagac aagtatagct acactattga ctccaaccag gagttcctgg     1260

cacatggtgc ctccaacctc atctcctccc tcttctcttg ctttcccaac tcggctacgc     1320

tggccaccac caatctactg gtggatgctg gtgggaaaac acagctggca ggcctcttct     1380

cctgcacagt ggtcctgtcg gtgctgctgt ggctggggcc cttcttttac tatctgccca     1440

aggctgtcct ggcttgcatc aacatctcca gcatgcgcca ggtgttctgc cagatgcagg     1500

aacttccaca actatggcac atcagccgag tggactttct cctccaggtc ccggggctct     1560

gcatcctgag ctatccaaca ccactgtact ttgggacccg tgggcagttt cgctgcaacc     1620

tggagtggca cctggggctc ggagaaggag aaaaggagac ttcaaagcca gatggcccaa     1680

tggttgcagt tgctgagcct gtcagggtgg tggtcctaga cttcagtggt gtcacctttg     1740

cagatgctgc tggggccaga gaagtggtgc aggtgaggga gaggctggcc agccgatgtc     1800

gagatgctag gatccgcctc ctcctggctc agtgtaatgc cttggtgcag gggacactga     1860

cccgggtagg actcctggac agggtgactc cagatcagct gtttgtgagt gtgcaggatg     1920

cagctgctta tgccctgggg agcctgttaa ggggcagtag caccaggagc gggagccagg     1980

aggcactggg ctgcggcaag tgaggcaggg gtaagtggct ggagacccag ggagaggggt     2040

ttgggaaagg gtctgaggaa gatcaagaag aaaagggtgg ggacggaatg aatagtagat     2100

tgaagaccaa atcagggagc ccgggctgag ctatgggtga ggaactgaag aactcagatc     2160

cctaagtagg tggggtaccc ctgagaggac tgccacattt cattaaggaa gaggggtgcc     2220

taatctattc ctgacatgtc tcctctcttc tccaggagct cactgaccca aagatttgca     2280

ccgtgtgggt ctgacctcat catgtggagt gcagagggcc ctgatgacat gtgtgtgatg     2340

aggaccatga cccttgaacc cccttaccta acgtaactaa taaaatgaa                 2389


<210> 907
<211> 4392
<212> DNA
<213> Homo sapiens

<400> 907
cctcggcctc cgtaaccccc gcctagccgg gccatggcgg aacgcggagg ggcgggcggt       60

ggtcccggag gcgccggggg cggcagcggc cagcggggat ccggggtcgc ccagtcccct      120

cagcagccgc cgccgcagca gcagcagcag cagccgccgc agcagccgac gccccccaag      180

ctggcccagg ccacctcgtc gtcctcgtcc acctcggcgg cggctgcctc ctcctcgtcc      240

tcgtctacct ccacctccat ggccgtggcg gtggcctcgg gctccgcgcc tcccggtggc      300

ccggggccag gccgcacccc cgccccggtg cagatgaacc tgtacgccac ctgggaggtg      360

gaccggagct cgtccagctg cgtgcctagg ctattcagct tgaccctgaa gaaactcgtc      420

atgctaaaag aaatggacaa agatcttaac tcagtggtca tcgctgtgaa gctgcagggt      480

tcaaaaagaa ttcttcgctc caacgagatc gtccttccag ctagtggact ggtggaaaca      540

gagctccaat taaccttctc ccttcagtac cctcatttcc ttaagcgaga tgccaacaag      600

ctgcagatca tgctgcaaag gagaaaacgt tacaagaatc ggaccatctt gggctataag      660

accttggccg tgggactcat caacatggca gaggtgatgc agcatcctaa tgaaggcgca      720

ctggtgcttg gcctacacag caacgtgaag gatgtctctg tgcctgtggc agaaataaag      780

atctactccc tgtccagcca acccattgac catgaaggaa tcaaatccaa gctttctgat      840

cgttctcctg atattgacaa ttattctgag gaagaggaag agagtttctc atcagaacag      900

gaaggcagtg atgatccatt gcatgggcag gacttgttct acgaagacga agatctccgg      960

aaagtgaaga agacccggag gaaactaacc tcaacctctg ccatcacaag gcaacctaac     1020

atcaaacaga agtttgtggc cctcctgaag cggtttaaag tttcagatga ggtgggcttt     1080

gggctggagc atgtgtcccg cgagcagatc cgggaagtgg aagaggactt ggatgaattg     1140

tatgacagtc tggagatgta caaccccagc gacagtggcc ctgagatgga ggagacagaa     1200

agcatcctca gcacgccaaa gcccaagctc aagcctttct ttgaggggat gtcgcagtcc     1260

agctcccaga cggagattgg cagcctcaac agcaaaggca gcctcggaaa agacaccacc     1320

agccctatgg aattggctgc tctagaaaaa attaaatcta cttggattaa aaaccaagat     1380

gacagcttga ctgaaacaga cactctggaa atcactgacc aggacatgtt tggagatgcc     1440

agcacgagtc tggttgtgcc ggagaaagtc aaaactccca tgaagtccag taaaacggat     1500

ctccagggct ctgcctcccc cagcaaagtg gagggggtgc acacaccccg gcagaagagg     1560

agcacgcccc tgaaggagcg gcagctctcc aagcccctaa gtgagaggac caacagttcc     1620

gacagcgagc gctccccaga tctgggccac agcacgcaga ttccaagaaa ggtggtgtat     1680

gaccagctca atcagatcct ggtgtcagat gcagccctcc cagaaaatgt cattctggtg     1740

aacaccactg actggcaggg ccagtatgtg gctgagctgc tccaggacca gcggaagcct     1800

gtggtgtgca cctgctccac cgtggaggtc caggccgtgc tgtccgccct gctcacccgg     1860

atccagcgct actgcaactg caactcttcc atgccgaggc cagtgaaggt ggctgctgtg     1920

ggaggccaga gctacctgag ctccatcctc aggttctttg tcaagtccct ggccaacaag     1980

acctccgact ggcttggcta catgcgcttc ctcatcatcc ccctcggttc tcaccctgtg     2040

gccaaatact tggggtcagt cgacagtaaa tacagtagtt ccttcctgga ttctggttgg     2100

agagatctgt tcagtcgctc ggagccacca gtgtcagagc aactggacgt ggcagggcgg     2160

gtgatgcagt acgtcaacgg ggcagccacg acacaccagc ttcccgtggc cgaagccatg     2220

ctgacttgcc ggcataagtt ccctgatgaa gactcctatc agaagtttat tcccttcatt     2280

ggcgtggtga aggtgggtct ggttgaagac tctccctcca cagcaggcga tggggacgat     2340

tctcctgtgg tcagccttac tgtgccctcc acatcaccac cctccagctc gggcctgagc     2400

cgagacgcca cggccacccc tccctcctcc ccatctatga gcagcgccct ggccatcgtg     2460

gggagcccta atagcccata tggggacgtg attggcctcc aggtggacta ctggctgggc     2520

caccccgggg agcggaggag ggaaggcgac aagagggacg ccagctcgaa gaacaccctc     2580

aagagtgtct tccgctcagt gcaggtgtcc cgcctgcccc atagtgggga ggcccagctt     2640

tctggcacca tggccatgac tgtggtcacc aaagaaaaga acaagaaagt tcccaccatc     2700

ttcctgagca agaaaccccg agaaaaggag gtggattcta agagccaggt cattgaaggc     2760

atcagccgcc tcatctgctc agccaagcag cagcagacta tgctgagagt gtccatcgat     2820

ggggtcgagt ggagtgacat caagttcttc cagctggcag cccagtggcc cacccatgtc     2880

aagcactttc cagtgggact cttcagtggc agcaaggcca cctgaggccc tgtctcccag     2940

ccactttccc tcctggcact gccaccagcc tcaccgcctg cgggcagggg gaggccagca     3000

ggcccgggcc cagcacccct tccctggcac cagggtctgc ctctcactcg cccaggtccc     3060

gaaggacact gccacaggga cgccttccct cccctcccct ccagcccacc cctgcacagc     3120

ccctcctcct tcccgctttt ccccttctcc ctcctgctcc aggcccaagg cgtgttggtt     3180

ttgccttctg gtgcccatag tcccctggac tgagtccccc aggccttcct tcacccgact     3240

tccaaactct tccttgtggt atcagtttcc ttctcggaaa tgagaaagct ggaatcctgg     3300

tccccagcag gagagcctag tcctccccca gcccctccag ccaccagggt gtcctctagg     3360

atgcagctgc cagatccact cactctgctg cctccagcag gacccaaggc cactttcaac     3420

tcttatgggg ttctccacct gccccagagc ttctcaaggg agggtaaggg ggcaccctga     3480

gcccacagga cccctacttc acagctcaca ggggcaggag gcagctcccc tgcctccagg     3540

accctgttgc tatggtgaca cagcgtttct aggacagagg ggcctcccag tctcccccca     3600

ccacccgtgc acgacttcct caccaccccc aggttccctg cagatgtcgt gtgtgtcctg     3660

agtgtttctt tggttctttg cacgccaagt ctcttggttg taccatgtga cacaccctgt     3720

gcactggtcg ctgtcttcgt ggcttccacc cttgttaatg atgctcctgc ctctgcctcc     3780

cagcccctca cccagcacag ctctgcctgg acttggagag atgggaggca gacccccacc     3840

accatacatg ctgtctgtgg cccctcagac attctgtttc atctcccatt catctccctc     3900

ctcccaccgt gtcagttttt ctgcctttcc ctgctctgtt cttccccctc cttaggcccc     3960

agcctgggcc cagacccatc ctcccagcca ggtttccctc cagcaggctc cttccctccc     4020

tgtcacctcc ctctcaccaa cccggggtct gagcccctca ttcctgaccg tccgtgttct     4080

caggagtggt tgaggacaca gggccccagc ccagccctct gcacccccca gcccggccat     4140

ctgcgcccca cagccccttt ggagcttttc tcttgtcctc tcactccttc ccagaagttt     4200

ttgcacagaa cttcattttg aaagtgtttt tctcattctc catacctccc ccaagctctc     4260

ctccagccct tcccagggct cagccctgct gtcctgagcg tctcctgggc cagagagagg     4320

agatgggggt gggagggact gagttgatgt tgggtttttc attcaataaa ttggtgattt     4380

cttaccgact gc                                                         4392


<210> 908
<211> 1601
<212> DNA
<213> Homo sapiens

<400> 908
aacggctaga gacgcccagt gagttagcat ggagggcagt gggaccggaa aaagacgtgg       60

aaaagctgcg aaaacgagcc ttcgaatcat ggacgcgcgg gcccagctcc tcctccgagt      120

tcctcatccg gggccgtcac tcacatccgg ggccctcact cacatccggg accctcatcc      180

ggggctctca cccacatccg ggaccctcat gcctgggcgg aggagggggg gccctcattc      240

gggaccctgc actccgtcgc cggaagtgcc accgagaagc gccggcctcg gggctgtcta      300

cagcggcccg ggagaggctg tggtggcccc gagcgcgagt gtgtaggtga caggacagcg      360

gccaggcccg cccctcccct cgtgatggtc attgtcctcc agagcagtga tggaggaaat      420

accagcccag gaagcagcag ggtcaccaag ggtccagttt cagtctttgg agacccagtc      480

tgagtgtctg tccccagagc ctcagtttgt gcaggacacc gacatggaac agggactcac      540

tggggctcca cctgttcctc aggtgcctgc tcttccccgt gagggaagcc caggagacca      600

ggcagctgcg ctcttgacag ccaggtacca ggagtttgtg acattcgagg atgtggctgt      660

gcaccttact cgagaggaat ggggatacct ggaccctgtt cagagggacc tctacagaga      720

agtgatgtta gagaattatg ggaacgtggt ctcactgggc atacttctcc gccttcccac      780

cacccggatt catagtgtga attcctgccc ggccctgagt catacccagg caagtgcttt      840

ctctggagaa acacttgccg tccttacagc aggaatctcc aagagatggc ccaagtatcg      900

gcttcccatc gatattgctc gtccctgctc ggaaactcct tttccacgat tgtgagatat      960

taaaattgac tgatggaata gaagctcccc aggatgccac cactgtgtaa aatcgcagct     1020

cctcaaatta cctctgttta atttcaaatg ttagggtcca aggaagccct ctgttgcaac     1080

cagatatgtt ttgaacccag ttcattcaga aaccatggtt ggtggtcatc atctacttgt     1140

attgtgaaaa accagaaatt ccaaattcag ctcttcagtt atggtctttt catattattt     1200

tagaatgtga aacttatgct gtgtgcccct ccttttatgt ggcgaacaca acctgccccg     1260

tatggtgcct aactctcctg tgaaccctgg gcttccctca tgtttaacat tctggtttcc     1320

tccttccttg aagtccctgt ggccctcttc aaggtcctac cttcctaccc tttattcttt     1380

gtggttctgt acagattgat gcaattatat tgcctttcct gattaagtgt tccttactct     1440

gtccttgatg gaggggagaa gggagggcaa agaagttaaa tttatttcag ggcatcaaat     1500

tgaatatcta cttaataact ttgtaaactg taaagtgaca tacatataat tgtaaagtac     1560

tgttaatttt atctaataat tacagagttt ccaacagtta a                         1601


<210> 909
<211> 2740
<212> DNA
<213> Homo sapiens

<400> 909
gctgttcgcg ctcatccccc tcccccggcc ctgggtgtcc ccgtgacgag gcagcgcgga       60

gccgccgcgg gccgggccca tcccgccgca gcggcccggg gccgagcagg ggctaggcgg      120

ggagggagcg gcgcccagcg gggcccggag cgtggccaga atggtgctgg aaggaaaccc      180

tgaagtgggg tccccccgaa cctcagacct ccagcaccgg gggaacaagg gctcttgcgt      240

tctctcctct cccggtgaag atgcgcagcc aggcgaggag cccatcaagt atggtgaact      300

catcgtcctg ggatgctgtg aggaaggagg tgaggaaacc gaggctcaga gaggggaagt      360

gactggccca agggcacaca gctgctacaa tggttgtctg gcaagtgggg acaagggccg      420

ccggcgaagc cgcctggcac tgagccgccg gtcgcacgcc aacggggtga agccagacgt      480

catgcaccac atctccacgc cgctcgtctc caaggcactg agtaaccgtg gtcagcacag      540

catctcgtat acactgtccc ggagccactc ggtcatagtg gagtatacac atgatagcga      600

cacagacatg ttccagattg gccgctccac agagaacatg attgacttcg tggtaacaga      660

cacgtcccct ggaggagggg ctgccgaggg cccttctgcc cagagcacca tctcccgcta      720

tgcctgccgc atcctctgtg accgccggcc accctatact gcccgcatct atgccgctgg      780

cttcgatgcc tctagcaaca tcttccttgg agagcgagcg gccaaatggc ggaccccaga      840

tggcctgatg gatggactga ccaccaatgg agtcctggtg atgcacccgg caggcggctt      900

ctccgaggac tcagccccgg gtgtctggcg ggagatctcg gtctgtggga atgtgtacac      960

attgcgggac agccgctcag cccagcagcg gggcaagctg gtggaaaacg agtccaacgt     1020

gctgcaggac ggctctctca tcgacctgtg tggggccaca ctgctgtggc gcacaccggc     1080

ggggctgctg cgggctccca cactgaagca actggaggcc cagcggcagg aggcaaatgc     1140

agcgcggccc cagtgccccg tgggcctcag cactctggcc ttccccagcc cagcccgtgg     1200

ccgcacagcg cccgacaaac agcagccctg ggtctacgtc cgctgcgggc acgtccatgg     1260

ctaccacggc tggggctgcc ggcgggagcg gggcccccag gagcgcgaat gtcctctctg     1320

ccgccttgtg gggccttatg tgcctctatg gcttggccag gaggccggcc tctgcctgga     1380

ccctgggccg cctagccatg cctttgcacc ttgcggccac gtctgctctg agaagactgc     1440

ccgctactgg gcccagacac cactgcccca cggcacccat gctttccatg ccgcctgccc     1500

cttttgcggg gcctggctta ccggcgagca tggctgcgtc cgcctcattt tccagggccc     1560

gctggattag gctccctggg gccccctgct gctgtgccca cctgcccacc caggtcccca     1620

cctcctgcag cccagaggga gctctgcatg tgggacactc cctgctggca cagccacacc     1680

agatggacat gttggatggg ctgtgccctt ccccccaact gtggcccccc aaggaggtcc     1740

ccaagatctc caccccagtc atgctgatgg ggccttcagc accagctctg tcctgggtcg     1800

atggaggaaa gcccagcccc atggccttgc ccttcctggg gcatcccaca tcgtgccgcc     1860

gacactgtgt gcccctgggg gagtgaaggg gccaggggcc tttgaccccc agcttaggct     1920

ggctatgccc tgagcctgcc aacccagttt cagacactca tccttcatcc ttcctgctgc     1980

cgccctgggt tcctctataa acctcgctgc tcagctgccc ccacaagtcc cacatgcccc     2040

gcatgcgtgc aatgcctcca gcccccaagt gagtggtggg tgggtggcag gctgggccta     2100

gcacttgctg atagccacta tgggctcgac tctgtgctaa gtggtatctg gggacacaga     2160

ggcaatcaga cctggttccc cccctggtgg agttcacagt ctagtggagg acagactgtt     2220

aacaaatggc aacacggctt catgcgtgcc aggatcagag tacaaatcag gctgtggcag     2280

gcctcactgg taatggaaaa gtgagggagg cttcacggag gaggtgtcat aggagctcag     2340

cctcaacggc tgctcggaac cctccgagtc cacaagatgg gaagcaagtc cacaagatgg     2400

gaagcgtgct ctatacagaa gggagggcct gtgcacaggc tcaggtgtca gtaagccaga     2460

aatccaggga cagagtcagg atggctggag catggactgc ggggggaaca gagaaggggg     2520

tggagcaaaa ggttgggacc atgtgaccag ggaagatgct ggatggagga ttctgaacct     2580

catttgtgga cggtcaggag tcaacaaagg gaggagagag gactcactgg tcaagagtgt     2640

cggctgtgac acaagggcca tcatccctga atgcccacca tgtgccccgc actgtgctga     2700

tgatgataat aataactacg tccattgagc actctccaga                           2740


<210> 910
<211> 7919
<212> DNA
<213> Homo sapiens

<400> 910
ccagctcgcg ctgcccgggc gggcgccggc cgctggcgcc gctactgctg ccgcccccgg       60

ggcgcgagtc cgccgcccgc cgcccgggca cccggcgagg ggcgggggca gctccgaacc      120

ggccccagat ccttcccgct tccgcctcac gcttcccgga aagcttgtcc ctctccgccg      180

agctgctccg ggagccccgc cgcgccgagg gtatctccca gagccccagc tggtgtggcc      240

aggccccagg agtaggatgg ggctccccct acgagggccg gtggcagcca gaactgatac      300

agcccccctg gtctggggcc aggacgccag ctgaggaggg caggagtgtc tggagctatg      360

gctggtgcct cggtgaaagt ggcagtgagg gttcggccct ttaacgcccg tgagaccagc      420

caggatgcca agtgtgtggt cagcatgcag ggcaacacca cctccatcat caatcctaaa      480

cagagcaagg atgcccccaa aagcttcacc tttgactact cctactggtc acacacttcg      540

acggaggacc cccagtttgc atctcagcag caagtgtatc gggacattgg agaagagatg      600

ctgctccacg cctttgaagg ctacaacgtg tgcatctttg cctatgggca gaccggggct      660

gggaaatcct ataccatgat ggggcgacag gagccagggc agcagggcat cgtgccccag      720

ctctgtgagg acctcttctc tcgcgttagt gagaaccaga gtgctcagct atcctactct      780

gtggaggtga gctatatgga gatctactgt gagcgggtac gagacctctt gaaccccaag      840

agtcggggtt ctctgcgggt ccgggagcac cccatcctgg gcccgtacgt gcaggacctg      900

tccaaattgg ctgtgacctc ctacgcagac attgctgacc tcatggactg tggaaataaa      960

gcacggactg tggctgccac caacatgaat gagaccagca gccgttccca tgccgtcttt     1020

accatcgtct tcacacagcg ctgccatgac cagctcacgg ggctggactc ggagaaggtc     1080

agtaagatca gtttggtgga ccttgctggg agtgagcgag ccgactcctc aggggcccgg     1140

ggcatgcgcc tgaaggaagg agccaacatc aataagtccc tgactacact agggaaagtg     1200

atctcggccc ttgcagatat gcaatcaaag aagcgaaagt cggattttat cccctacagg     1260

gactctgtgc tcacctggct gctcaaggaa aatttggggg ggaactcacg cacagccatg     1320

attgcagccc tgagccctgc tgacatcaat tacgaggaga ctctcagcac cctcaggtat     1380

gctgaccgca ccaagcaaat ccgctgcaat gccatcatca acgaggaccc taatgcccgg     1440

ctgattagag agctgcagga ggaagtagcc cggctgcggg aactgctgat ggctcaggga     1500

ctgtcagcct ctgctctgga aggcctgaag acggaagaag ggagtgtcag aggcgccctg     1560

ccagctgtgt catctccccc agctccagtt tcaccctcat cacccaccac acataatggg     1620

gagctggagc cgtcattctc ccccaacacg gagtcccaga ttgggcctga ggaagccatg     1680

gagaggctgc aggagacaga gaagattata gctgagctga acgagacatg ggaggagaag     1740

ctacgcaaga cagaagccct gaggatggag agagaagcat tgctggctga gatgggggtg     1800

gccgtccggg aggatggggg aactgtgggc gtcttctctc caaagaagac tccccacctg     1860

gtgaacctga acgaagaccc tctgatgtct gagtgtctgc tctaccacat caaagatggc     1920

gtcaccaggg tcggccaagt agatatggac atcaagctga ccggacagtt cattcgggag     1980

caacactgtc tgttccggag catcccccag ccagatggag aagtggtggt cactctggag     2040

ccttgtgaag gagctgagac atatgtgaat gggaagcttg tgacggagcc gctggtgctg     2100

aagtcaggga ataggattgt gatgggcaag aaccacgttt tccgcttcaa ccacccggag     2160

caggcaaggc tggaacggga acgaggggtc cccccacccc caggaccgcc ctctgagcca     2220

gtcgactgga actttgccca gaaggaactg ctggagcagc aaggcatcga cataaagctg     2280

gaaatggaga agaggctgca ggatctggag aatcagtacc ggaaagaaaa ggaagaagcc     2340

gatcttctgc tggagcagca gcgactgtat gcagactcgg acagcgggga tgactctgac     2400

aagcgctctt gtgaagagag ctggaggctc atctcctcct tgcgggagca gctgccgccc     2460

accacggtcc agaccattgt caaacgctgt ggtctgccca gcagtggcaa gcgcagggcc     2520

cctcgcaggg tttatcagat cccccagcga cgcaggctgc agggcaaaga cccccgctgg     2580

gccaccatgg ctgacctgaa gatgcaggcg gtgaaggaga tctgctacga ggtggccctg     2640

gctgacttcc gccacgggcg ggctgagatt gaggccctgg ccgccctcaa gatgcgggag     2700

ctgtgtcgca cctatggcaa gccagacggc cccggagacg cctggagggc tgtggcccgg     2760

gatgtctggg acactgtagg cgaggaggaa ggaggtggag ctggcagtgg tggtggcagt     2820

gaggagggag cccgaggggc ggaggtggag gacctccggg cccacatcga caagctgacg     2880

gggattctgc aggaggtgaa gctgcagaac agcagcaagg accgggagct gcaggccctg     2940

cgggaccgca tgctccgcat ggagagggtc atccccctgg cccaggatca tgaggatgag     3000

aatgaagaag gtggtgaggt cccctgggcc ccgcctgaag gatcagaggc agcagaggag     3060

gcagccccca gtgaccgcat gccgtcagcc cggcccccct cgccaccact gtcaagctgg     3120

gagcgggtgt cacggctcat ggaggaggac cctgccttcc gtcgtggtcg tcttcgctgg     3180

ctcaagcagg agcagctacg gctgcaggga ctgcagggct ctgggggccg gggcgggggg     3240

ctgcgcaggc ccccagcccg ctttgtgccc cctcacgact gcaagctacg cttccccttc     3300

aagagcaacc cccagcaccg ggagtcttgg ccagggatgg ggagcgggga ggctccaact     3360

ccgctccaac cccctgagga ggtcactccc catccagcca cccctgcccg ccggcctccg     3420

agtccccgaa ggtcccacca tccccgcagg aactccctgg atggaggggg ccgatcccgg     3480

ggagcgggtt ctgcacagcc tgaaccccag cacttccagc ccaaaaagca caactcttat     3540

ccccagccac cccaacccta cccagcccag cggcccccag ggccccgcta ccccccatac     3600

actactcccc cacgaatgag acggcagcgt tctgcccctg acctcaagga gagtggggca     3660

gctgtgtgag tcccacatcc tgggcagagg gcctggtggg gccccttgct aggagaaggg     3720

aagacgcccg agacgctgct tccccagaag tgctggggca gggaggccca ggagatgaga     3780

gagaaggtcc gagtaggtga tagaagacaa gggggagacc gagccggagg ctgaggaaag     3840

gaagagggca cggagttgcc aggagcaaac caaagtgaag agagagatag gaagctgcct     3900

cggggccacc ccttgcaaag ggggtgtgtc ccacaaacgc tgctatgggt ggggtggggg     3960

gctggggtgc tgcgtagcca gtgtttgact ttcttttcaa gtgggggaaa gtgggagagg     4020

actgagagtg aggcaagttc tccccagccc ctgtccgtct gtctgtctgt ctgtggtggt     4080

ttctgtttct tgggaggcat ggtaggatca taagtcattc ccctcccctt ccaggcctcc     4140

tgctatattt gggggacctg actggtttgg ctggagtccc atgaggatgt gggcccttta     4200

ataaaggata gcaaacaggg agcttgtggc ctgtttgttt tgggttttca tggaggtgta     4260

ggttatataa ggcaatggca caggtcttaa gcatacttat cagtgaagta ttgtatgtgt     4320

gctctgtgca ggcaccaccc agatctggat ataagaatgt ttccatcttg tcttcctgaa     4380

cttcaccctc ctgtctcttc cttcagggtg cgcagcccga tcttttcccc gctttttttt     4440

tttgggagac agggtcttgc tttgttgccc aggctggagg tacagtcttg gctcactgca     4500

gcctccgcct cctgagtagc tgggattaca ggcatgtgcc accacgcccg gctcattact     4560

gttttttttg tagtgacgag gtttcaccat attggccagg ctggtctcga actcctgatg     4620

acctcaagtg atccgcccac cttggcctcc caaagtggtg ggattacagg tgtgagccac     4680

cgcgcccggc ctcccctgct ttcatgtttg cttacccagt gtctcagtct gtgccagcag     4740

caccactgtc tgttatggac aaagcacaga agcggggatg cgaggggagg tagagggacc     4800

gccagcctgt caatgcttaa ctggctgttg ctgacagata cagaaggatt tgtggggtac     4860

agaggagttc tgctttaagt cacctaactt acttgaaagg tctcccaagc agccagtttc     4920

tcttgatagt gaatgggttg ggcaagcata ctgcgcttac ctgattgttt tcatcctggt     4980

tgtgttacct gccttctggc aggctacatc attgttccca gtcgttattt tatttgtgtt     5040

aagactgttt gttggccagg cgcagtggtt cacgcctgta atgccagcac tgggaggccg     5100

aggcaggtgg atcacgaggt caggagatcg agaccatcct ggctatcatg gtgaaacccc     5160

atctctacta aaaataaaaa taaaaaaatt agccgggcat ggtggcgggg gcctgtagtc     5220

ccagctactc aggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag     5280

tgagctgaga ttgcgccact gcactccagc ctgggcgaca gagcgagact ccatttcaag     5340

aaaaattaaa aaactgtttg ttgcctgctt gttttaatgt tctggcttga ggcagcgagc     5400

ccttgactat gccacattgc caggattttg caggttagat tgtactacag cactgccttt     5460

ggcttgccag actctggagt ccccacattt tcatcctgtt ctcaggaaaa cactttgacc     5520

cacttgaagc tctgagctac tgcttcacag cttcctgggg tcagtctcca gccaaaacca     5580

tagatatccc aactgcagcc aaaccacggc tctgggcgaa ggaacgatta ggtttactct     5640

aggtttccac accctgatgc tcctgccttt actttgacac ctctgactgc caggttttca     5700

cagacctgtt gacagtgact caagatctgg aatgtaatgg atggtttggc aacagtgttt     5760

gcttgagcag tttaaaatct ggccagggag actcaatgtg agcaagaaaa tgatagaata     5820

ccaagttttc tggaggtcag agggagctga gttgagtgtt accgagaatg ctgtggggtt     5880

tgagatgaga aaaatagctt gctaatttaa aagacggatt atttttccct aaagaccttg     5940

acttatgtaa atgtatatta tccataattt taaaaatcca cttatggctg ggcacagaag     6000

ctcacacctg taatcccagc actttgggag gctgaggcag gaggatcagt tgagtccagg     6060

agttcgagac cagcctgggc aacatagtga aaccctgtat ctacaaaaca tagaaaaact     6120

agttgggtgt ggtggtgtgt acctgtagtt ccagctacta gggaggtagg aagatcacct     6180

gagcccatgg agattgaggc tgtggtgagc tgtgaaggca ccacagcact ctggcctggg     6240

caagagtggg actctctcaa aaaaaaaaaa aaaaaaaaat ccacatatcc agccttccaa     6300

gtcagtcttt aataatgtgc acgggccagg cacagtggct cacacccgta atcccaacac     6360

tttggaatat tagggtggga gcatcacttg aggccaggaa tttgagacca gcctgggcaa     6420

catagtgaga ctgccccccc catctctaca aaaaataaaa atcaaaaata atactgtggg     6480

caaactttac ttagatttta ttcagagtag tgcctgttta tttttcatct gtgctacctg     6540

tgccggcatt ccatatgcat ttgatttagt ctttaaagta ccccggtaaa ataggtcttt     6600

tgtctgcatt tttcagatgg gaagactgag gttttgttta tttattttta tttatttatt     6660

ttttgagacg gagtctcgct ctgttgccta ggctggagtg cgatggcaca atcttggctc     6720

actacaacct ccgcttcctg ggttcaagcg attctcctgc ctcagcctcc tgagtagcta     6780

ggattacagg cgcccacaac cgcacccggc taattttttg tatctttagt agagacaggg     6840

tttcactatg ttgtccaagc tggtttcgaa ttcctgacct caggtgatcc acccgcctct     6900

gcctcccaaa atgttgggat tacaggcgtg agccaccacg cccagcctat ttatttattt     6960

ttttagaatc aagatcttgc tatgttgccc aggctgaact cgaactcctg ggctcaagca     7020

atcctgcctc ccaagccaag cagctggtac tgcaagcatg tgccaccgtg cctggctcct     7080

gaagactgag gttggtttag attaatgagt tgcccaaatt cagacagttc ttaagtggca     7140

aagttaggat tccaacccag gtcaacataa ctaaagccca aaccccatct cacccctcta     7200

ggccatcaag tattggctgg gtgcggtggt ttatgtctgt aatcccagca ctttgggagg     7260

cggaggcggg aggactgttt gagctcagga gtttgagacc agcctgggca acataacaag     7320

accctgtctc tacaaaaata tataaattag ccgggtgtac tggctcacac ctgtagctac     7380

ttgggaggct gaggtgggag gatcgcttga gcctgggagg tcaaggctgc ggtgacctgt     7440

gattgcacca ccaggagacc ctgtcttaaa aatgtatata taaaaataaa aagaacatca     7500

gacatcacca tcacctcgct tagaatccat ggggccttct cctcaaattc aatcttccca     7560

ggcatttcat gaacttgcgt ctagtttctg ttccctctca aattgcccag gctgtcctgt     7620

gagtgacagc agctatttcg tgggcctcct ctggaatcat gagaagtcac ccaaacaatc     7680

tcagttttct agctcactcc gtcttgacat ttctacactg tcatccttgg ttttcttgga     7740

aattaatttg cttttcttca ttgtctttct ttggagctgc tttccttttg ttggttacta     7800

ttttattttt agcttctcac accataccga catatgttgg ttattctttt agacatgttt     7860

tttgttgttg ttgtcacctg gaacttttgt atcttgaata aatttgggga tcaaataca      7919


<210> 911
<211> 4512
<212> DNA
<213> Homo sapiens

<400> 911
tgtggaggaa agtgtgccat ggcggagcct gtggggaagc ggggccgctg gtccggaggt       60

agcggtgccg gccgaggggg tcggggcggc tggggcggtc ggggccggcg tcctcgggcc      120

cagcggtctc catcccgggg cacgctggac gtagtgtctg tggacttggt caccgacagc      180

gatgaggaaa ttctggaggt cgccaccgct cgcggtgccg cggacgaggt tgaggtggag      240

cccccggagc ccccggggcc ggtcgcgtcc cgggataaca gcaacagtga cagcgaaggg      300

gaggacaggc ggcccgcagg acccccgcgg gagccggtca ggcggcggcg gcggctggtg      360

ctggatccgg gggaggcgcc gctggttccg gtgtactcgg ggaaggttaa aagcagcctt      420

cgccttatcc cagatgatct atccctcctg aaactctacc ctccagggga tgaggaagag      480

gcagagctgg cagattcgag tggtctctac catgagggct ccccatcacc aggctctccc      540

tggaagacaa agctgaggac taaggataaa gaagagaaga aaaagacaga gtttctggat      600

ctggacaact ctcctctgtc cccaccttca ccaaggacca aaagcagaac gcatactcgg      660

gcactcaaga agttaagtga ggtgaacaag cgcctccagg atctccgttc ctgtctgagc      720

cccaagccac ctcagggtca agagcaacag ggccaagagg atgaagtggt cttggtggaa      780

gggcccaccc tcccagagac cccccgactc ttcccactca aaatccgttg ccgggctgac      840

ctggtcagat tgcccctcag gatgtcggag cccctgcaga gtgtggtgga ccacatggcc      900

acccaccttg gggtgtcccc aagcaggatc cttttgcttt ttggagagac agagctatca      960

cctactgcca ctcccaggac cctaaagctc ggagtggctg acatcattga ctgtgtggta     1020

ctaacaagtt ctccagaggc cacagagacg tcccaacagc tccagctccg ggtgcaggga     1080

aaggagaaac accagacact ggaagtctca ctgtctcgag attcccctct aaagaccctc     1140

atgtcccact atgaggaggc catgggactg tcgggacgga agctctcctt cttctttgat     1200

gggacaaagc tttcaggcag ggagctgcca gctgacctgg gcatggaatc tggggacctc     1260

attgaggtct ggggctgaca ccccactccc tgtttgacgg cccagcctgg acttggggag     1320

aatgactttc ccttttttgc cccataaggg ctagcataag ctgaggtaga acttatcttt     1380

aagctgcagc aaaatcaagg agtgactttt gtcccctctc ctgttgaccc tggtttagag     1440

ccgttaacca cttggtgagt tatgtgggtg ttgttgccct gggtggcctg tggctccgtc     1500

cacaagtcat gctgagtttt gcagcctctg tgacttggag atgtcccttc acccctcccc     1560

tttcaccacc atcctctttt cctcatggaa atgtctgctt tatgaaacta tgcacatatt     1620

gaaagtgagt tgaaacaaat gagggttggg taggagcttc caggcctggg atttacacca     1680

cgcctagccc agcagaggcc ttagtcccat ttggggcttg ggagtgacat ttgcttgagg     1740

cttatacact ggtgtggttg cctggcttgc aggaaatgac caagctcaca catgctggct     1800

gaagcgtaag cagacaactg aggtactctt ttgaaggatg aaggtggtgg attctcagcc     1860

ctgggggtct tcctcacctg aggacccttc agagccaccc tttctagttt gcatttcctg     1920

gtgcacacat ttaaggcata acagcacatt catccctttg gtttgggatc tcaggaatac     1980

agtcccatgc aaagattctc tggttttatg gcttttttcc ctttctttac accatcctct     2040

cccataagca cccatgtctt tgaatatgaa tgtatttgta aaataccacg tttcatgtgt     2100

gaatatgtgc ttttactgta catagtgcta ttgtgcaata ggtcttatgc tgttttcact     2160

caatgtgtgc taagatctag ccccattgac tcttctagaa atgcagtatt gctttgacct     2220

gccatgtggc actccacaat gtcaattgca gtttacacac attgcctaaa gtgggggaca     2280

cctgggtgcc cctgacccct tggcaccgga tacaggccac gataaacatc ctttcgtgtg     2340

ttcccttctg tgcttgtgtg gcatgtgtac ccaggatggg cctataggtc acagaggtca     2400

gtttctcttt ggttttccag attttcttta gaacggtgac tgaccctcct acttgaggcc     2460

gcccttttct ccttatcctt gccagcactt gtattgccag actacctaat ttttgccagt     2520

ctcatgggta gatagtggtg cagtgcttta acatacattc atctgatcag cattaatttg     2580

gggaattttt tcacttagcc tttctggttt cccttcctgt gcattgccca ttttctcatg     2640

gagtttctta tcttttttgg tttattctca ggagttgctt gtacattctt gggcaattgc     2700

agataattcc aagaatgcat atttgggctg ggtatggagg ttcactggta atcccagcac     2760

tttgggaggc ccaggcagaa ggatcgctgc agcccaggag ttcgagacta gcctgggcaa     2820

catagcgaga cctcgtctct acaaaaaaaa attaaaaagg gggctttggg aggccaaggc     2880

gggcagatca tgagggcagg agattgagac cctcctggcc aacatggtga aaccccgtct     2940

ctactaaaat acaaaaaatt agctgggcat ggtggcgcac acctgtagtc ccagctactc     3000

tggaggctga ggcaggggaa tcgcttaaac ccaggaggcg gagattgcag tgagccaagg     3060

ttccaccact gcactccagc ctggcgacag agcaaggctc cactcaaaaa aaagatttaa     3120

aggggaaaaa attgaaattt tctttgtatc taggggtatc cgtcactgaa cagaaattct     3180

taattttggc taggcgtgat ggctcaggtc tgtaatccca gcactttcgg tggccggggt     3240

gggtggatca cttgaggcca ggagttcaag accaccctga ccaacttggt gaaatcccat     3300

ctctactaaa aatacaaaaa ttagctgggt gcagtggcgc atgcttgtaa tcccagctac     3360

tcaggaggca gaggcaggag aatcacttga acccgggagg tggaggctgc agtgaacaga     3420

gacagtgcca ctgcacatca gcctgagtga cagagagact ttgtctcaaa aaaaaaagaa     3480

aattttaatt ttaatgtaga cagtatgaat tatcttgttc tgcagttggt tgctttttga     3540

ttgcttattt aatagagttg ttaagatatt ttacatcttc tcctgttagc tgttcagctt     3600

ttcctttcat attgagaaca ctacacagtg ctgaagtcca gctggtacac accggggtga     3660

caccttggct gcatctgttc tcaacagtca gacacttctt ctaattggtt gatgctgggc     3720

tgtactggtt gctaaatatt gcacatcatt ttaaaactat ttgagatgca cttttgtact     3780

caggaggcca aggcaggagg attgcttgag cccaggagtt tgagaccagc ctgggcaaca     3840

cagcgagacc ttgtctctta aaaaaaaaaa aaaaaaaaaa tgagagaaat cggctgggca     3900

tggtttctca tgcctgtaat cccagaactt tgggaggctg aggcaggtgg atcaccggag     3960

gttaggaatt caagactgaa accttgtctc tactgaaaat acaaaaaaaa aaaaaaaaaa     4020

aaatgagcta ggtgtggtgg caggcgcctg taatcccagt tacttcggga ggctgaggca     4080

ggagaatcgc ttgaacccag gaggcagagg ttgcagtgag ccaagatcgc gccattgcac     4140

tccagcctgg gcgacaagag tggaaactct gtctcaaaaa aaaaaaaaaa aattcagtga     4200

aatacacctt tatatatgag atccaagttt cactttttgt gatataatga gccagttttc     4260

tcagtaatgt ctactaaaaa aaaagccatt aacctttctc taatatttgc atgattctaa     4320

taaaagtatg tcaacttctt aaaatgtttt attgaaatgt ggcattcctt tgaattttat     4380

gacattaaaa taatccacga catggtacag ctcttcactt tttcagcttt ttaaatgtcc     4440

attaataagt ttgaatacgt taaaattata tgtttaacct caacaaaata aatggcaata     4500

tgttcaactt gt                                                         4512


<210> 912
<211> 2049
<212> DNA
<213> Homo sapiens

<400> 912
gtctcactct gatgcacagg ctggagagca gtggcgcgat atgggctcac tgcaacctcc       60

gcctcccgtt ttcaaacgat tgtctcagcc tcccaagcag ctggggttac acgcgtgcaa      120

cacgacgccc ggctaatttt tgtatttttg gtagagacgg ggtctcgcca tgtcggccag      180

gctggtctcg aattcctgac ctcaagccat ccacccacct cgcctcccaa cgtgctgaga      240

ttacaggcgt gagccaccgc gcctgggaag tgcgggaggc ctttttaaaa aatgtaaact      300

cgcgtgctca agaagcccta tcggagggaa acacccagaa gaggccaccc tccaaacaca      360

gggtaaaaca ggggtgacgc acagaggtaa cgggaaagca ggaacgagcg agagcgtgcg      420

gtcccgtacc tgcgcgtgcc tgcgtgcgcg tccgtgcggc cgcgacgccg ccgccggtgc      480

ctctctttct agacgtgcgc gcgcccgcag ctcgcccccc tgaccgtaaa gaggcccggc      540

tgtgtcgtga aaggggccgc aacgcgcaga gcgctggttg acggccggga ctccattttg      600

ttcgccgtta ctctgcgcac atcgctattg cggttccgag gcagtgggaa gagatgcggc      660

ccctggacat cgtcgagctg gcggaaccgg aggaagtgga ggtgctggag cccgaggagg      720

atttcgagca gtttctgctc ccggtcatca acgagatgcg cgaggacatc gcgtcgctga      780

cgcgcgagca cgggcgggcg tacctgcgga accggagcaa gctgtgggag atggacaata      840

tgctcatcca gatcaaaacg caggtggagg cctcggagga gagcgccctc aaccacctcc      900

agaacccggg cgacgcggcc gagggccggg cggccaagag gtgcgagaag gccgaggaga      960

aggccaagga gattgcgaag atggcagaga tgctggtgga gctggtccgg cggatagaga     1020

agagcgagtc gtcgtgagcg cggtcggcgg tttccagcca atggattctg gtcaactggt     1080

ggagattggc tgacaccctg gagaagccga aaccagagag ccttttgttt tctctttttt     1140

cctgtctatg ctctgtctca cttaacacta cgttttctgc tatggtctgt ggttgatgac     1200

ctcaatatga gtttcgattg ttaacgtgtt tttgtttggg aagtaatttt gtttgaaaat     1260

gctctcacat acaggaatta gggcctagat tgtaagctct tgcagcagtc acatttgttc     1320

ccgggctttg gtggttattt ctaaattttt gaggtgcttt gctatttctt gtgtgacctg     1380

atagctccct ggaactttgg gtctgtgtgt gacacatgag actcacagtt ggagttctcc     1440

agctctggag gtgctgaagg agctgcatta attctggaag acgactccat gcagcaacta     1500

ctgaagaaag gaccagactt caacggggag tgtggatggg ccgacctggc tgggactcgt     1560

gaatctggag aagagctgga gaatggatag tattgtctgt atttggagac tttaatttct     1620

gtgtgagacc aaaggaggag agatgtgttt tgttcaaaat ttaaatttgt tgtggtacac     1680

tatcttatgt aacctgtctg gtgagtttgt ttggacaacc taactcagct ttatttgaca     1740

tggaacctaa aatagaagat aagatcttga tattctgtac aagttgatgt aataccctga     1800

tgcgttttag aggacttggc ataaaatgaa agattggcaa aggcccttga ggggcttggg     1860

gatgacagta tggaactgtc tgcattggac cctaaactgg actagaagag gcatcttcaa     1920

ggttcatacg ttgtccagct gtaagttcat ttgagtagca gacctaacaa atatttgagg     1980

tcagaaccct accatgttaa aacaaacaaa aacttaccat gttaataaaa gtattcattt     2040

gcttgaaaa                                                             2049


<210> 913
<211> 1993
<212> DNA
<213> Homo sapiens

<400> 913
tcctctccta ttatgcaaac ccacaccatg gatccagcag actactctgg ccccagcatg       60

ctgctccttg ggatgatggg agaaggggga aacctgtgtt ttctcttggt tttagggtat      120

gggtctactt ctttgaacat tcgctcagat cgtaaggtaa ccccaagaat cggcatcact      180

ctctggtctg ggcgcctgga tagtcacgca tggagtccgc gaggtgctgg cgccggagca      240

cgctgggaac gccgggctcc cggccggcct gacccggaag ggctggcgca tggtaacccc      300

agcttcccta gcaaccaagc aggcgcaaga agcaaccagc cgcgctatcc gctcccgttg      360

ctaccggaat gcctcttcag gttagcgatt acagctggca gcagacgaag actgcggtct      420

ttctgtctct gcccctcaaa ggcgtgtgcg tcagagacac ggacgtgttc tgcacggaaa      480

actatctgaa ggtcaacttt cctccatttt tatttgaggc atttctttat gctcccatag      540

acgatgagag cagcaaagca aagattggga atgacaccat tgtcttcacc ttgtataaaa      600

aagaagcggc catgtgggag accctttctg tgacgggtgt tgacaaagag atgatgcaaa      660

gaattagaga aaaatctatt ttacaagcac aagagagagc aaaagaagct acagaagcaa      720

aagctgcagc aaagcgggaa gatcaaaaat acgcactaag tgtcatgatg aagattgaag      780

aagaagagag gaaaaaaata gaagatatga aagaaaatga acggataaaa gccactaaag      840

cattggaagc ctggaaagaa tatcaaagaa aagctgagga gcaaaaaaaa attcagagag      900

aagagaaatt atgtcaaaaa gaaaagcaaa ttaaagaaga aagaaaaaaa ataaaatata      960

agagtcttac tagaaatttg gcatctagaa atcttgctcc aaaagggaga aattcagaaa     1020

atatatttac tgagaagtta aaggaagaca gtattcctgc tcctcgctct gttggcagta     1080

ttaaaatcaa ctttacccct cgagtattcc caacagctct tcgtgaatca caagtagcag     1140

aagaggagga gtggctacac aaacaagctg aggcacgaag agcaatgaat actgacatag     1200

ctgaactttg cgatttaaaa gaagaagaaa agaacccaga atggttgaag gataaaggaa     1260

acaaattgtt tgcaacggaa aactatttgg cagctatcaa tgcatataat ttagccataa     1320

gactaaataa taagatgcca ctattgtatt tgaaccgggc tgcttgccac ctaaaactaa     1380

aaaacttaca caaggctatt gaagattctt ctaaggcact ggaattattg atgccacctg     1440

ttacagacaa tgctaatgca agaatgaagg cacatgtacg acgtggaaca gcattctgtc     1500

aactagaatt gtatgtagaa ggcctacagg attatgaagc ggcacttaag attgatccat     1560

ccaacaaaat tgtacaaatt gatgctgaga agattcggaa tgtaattcaa ggaacagaac     1620

taaaatctta atgactatta gaagtaacta agtattgtta taagtttttt aaaaacaact     1680

ggaggcatct ttgtacatat tatggccagt tgtacagaat cgctttctgt ttagtacttt     1740

agttctgttg agggcaaaat attataaatc tatagaaaat aaactgtttg acttgaatca     1800

tttctgaata agtaaatcta aataagaatc tattttaatt ccttatttct tcatattaat     1860

acatatgtat acttttttgt gttactgaat taagcttgcc cttgtaacaa aatatgtttt     1920

ggtatagtta ccaggacact tactgattaa tttttaacaa ggtagaattt taaaataaaa     1980

gatttataaa taa                                                        1993


<210> 914
<211> 781
<212> DNA
<213> Homo sapiens

<400> 914
ggcatgctgg gggtgctagg taccgaaggc agatgccgtc cctttggact cgcttcgtcc       60

aacgccccca cgagtttcgg tggcccttcg ccccacgcta taagagcagt cacttccgga      120

actgctgccc ttcgcctttg ccgcgaaaag tgcctgacgg gggctgggaa gggggagggg      180

gaaggagtca acgactccct ccccgtcgtc attggctgag cgcctcgtga cgtcactctg      240

aggcgcctca tgcggcgccg cgcacgggtc ccagagcctt ctgggtagcg gtttaacccc      300

gcctcttgcg tcggcgcctt ccttttcctc cctgtcgcca ccgaggtcgc acgcgtgaga      360

cttctccgcc gcctccgccg cagacgccgc cgcgatgcgc tacgtcgcct cctacctgct      420

ggctgcccta gggggcaact cctcccccag cgccaaggac atcaagaaga tcttggacag      480

cgtgggtatc gaggcggacg acgaccggct caacaaggtt atcagtgagc tgaatggaaa      540

aaacattgaa gacgtcattg cccagggtat tggcaagctt gccagtgtac ctgctggtgg      600

ggctgtagcc gtctctgctg ccccaggctc tgcagcccct gctgctggtt ctgcccctgc      660

tgcagcagag gagaagaaag atgagaagaa ggaggagtct gaagagtcag atgatgacat      720

gggatttggc ctttttgatt aaattcctgc tcccctgcaa ataaagcctt tttacacatc      780

t                                                                      781


<210> 915
<211> 1801
<212> DNA
<213> Homo sapiens

<400> 915
ctcaacaggg cgtgtttttg tgtcactggt gtccctgagc tggaggtgat ctgtgggctg       60

cagcaggcgg aatggccccg tctgggattg agccacctgg gagctgtcgg cgggggttgg      120

ggcggccttc ccacctccac ctgggtttct cttcacactc aggaggtaga tctggcctcg      180

gaagtggcct tagaggtggt gcggacagca gagcctggcg tgtggttgga ggctcaggcc      240

ccggtggccc tggtggctca gcctgagccc ctgccggcca cagctggtgt gaagagggag      300

agcgtgggca tggaggtggc agtgctgact gatgacccgc tgcccgttgt ggaccagcag      360

caggtgctgg cccgtctgca gctgttggag cagcaggttg tgggtggaga gcaggccaag      420

aacaaggacc tgaaggagaa gcacaagcgg cgcaagcgct acgcagacga gcgcaggaag      480

cagctggtgg ctgccctgca gaactcggat gaggacagcg gggactgggt gctgcttaac      540

gtctacgact ccatccagga ggaagtgcgg gccaagagca agctgctgga gaagatgcag      600

aggaagcttc gggcagcaga ggtggagatc aaagatctgc agtccgagtt tcagctggag      660

aagatcgatt acttggccac catccgccgg caggagcgtg actccatgct cttgcagcag      720

ctcctggagc aggtgcagcc cctgattcgc agggactgta actacagcaa cctggagaag      780

attctgcgtg agtcctgctg ggacgaagat aacggcttct ggaagatccc acatcccgtc      840

atcacaaaaa ccagcctccc agtagcagtt tcaactgggc cacagaacaa accagcccgc      900

aaaacctctg cagcagacaa tggcgagccg aacatggagg acgaccgcta caggctcatg      960

ctcagtcgga gcaacagtga aaacattgcc agcaactact tccgatctaa gcgggccagc     1020

cagatcctca gcacagacgc caggaagagc ctcacacatc acaactcgcc accaggcctc     1080

agctgcccac tcagcaacaa ctctgccatc ccacccaccc aggcccctga aatgccccag     1140

ccccggccct tccgcctcga gtccctcgac atccctttca ccaaggccaa gcgtaagaaa     1200

agcaaaagca actttggcag tgagcctctg tgagcacagc tgcttgccat tgcctgcctt     1260

ataggcatgt agagactgcc aggccctccc agggcagccc caaccaggtc tcctcccacc     1320

tgccacacag cgctccgggg cctgagggct ccctcagccc tgggaagaca cattcccttc     1380

cctgttcccc agagagccca cctccgccct gggcaggagc ccctcggagg ctgtatagtc     1440

ctccttagag aggcctgctc cagctgttca taccacatca gtgtttccgt ctgctcacct     1500

gccacagagc ccacacccat gcccaccagt gttggtcttt gcctcaaagc ctgagacctg     1560

cttcacggcc ttcaccagcc ctgatggaga gggcagcagc tgccacgtgg aggaagctca     1620

atatcagctg ggaaggaact gtgcctctgt ctgactggcc ccacttccta agcactgccc     1680

tgccccatgg ggtggcacag gggtcccaca gcaggtcttc ctgcactgcc cacccctggc     1740

tggtctgtgg cccaaggaag gccactccac attaagctgc ccaataaact gcttttaaga     1800

t                                                                     1801


<210> 916
<211> 1546
<212> DNA
<213> Homo sapiens

<400> 916
aatcccgtgc ggcgcgcaca ggcaggaggt tgcagttggg cgctcagcag ctgtggcagc       60

cggttgaggt ctggcagtag cgttgggctg aagcagcgga gttcgccatg cgcgagtgta      120

tctctatcca cgtggggcag gcgggtgtcc agatcggcaa tgcctgctgg gaactgtact      180

gccttgaaca tggaattcag cccgatggcc aaatgccaag tgataaaacc attggtggcg      240

gggacgactc cttcaacacg ttcttcagtg agactggagc tggcaagcac gtgcccagag      300

cagtgtttgt ggacctggag cccactgtgg tcgatgaagt gcgcacaggg acctacaggc      360

agctcttcca cccggagcag ctgatcaccg ggaaggaaga tgcagccaat aattacgcca      420

ggggccatta caccatcggc aaggagattg ttgacctagt cctggaccgg atccgcaaac      480

tggcggatct gtgcacagga ctgcagggct tcctcatctt ccacagcttt gggggcggca      540

ctggctctgg gttcgcatct ctgctcatgg agcggctctc agtggattac ggcaagaagt      600

ccaagctaga gtttgccatt tacccagccc cccaggtctc cacagccgtg gtggagccct      660

acaactccat cctgaccacc cacacgaccc tggaacattc tgactgtgcc ttcatggtcg      720

acaatgaagc catctatgac atatgtcggc gcaacctgga cattgaacgt cccacgtaca      780

ccaacctcaa tcgcctgatt gggcagatcg tgtcctccat cacagcctcc ctgcgatttg      840

atggggccct gaatgtggac ttgacggaat tccagaccaa cctagtgccg tacccccgca      900

tccacttccc cctggccacc tatgccccag tcatctcagc tgagaaggcc taccacgagc      960

agctgtctgt ggccgagatc accaatgcct gcttcgagcc agccaatcaa atggtcaagt     1020

gtgaccctcg ccacggcaag tacatggcct gctgcatgtt gtacaggggg gacgtggtcc     1080

ccaaagacgt caacgcggcc atcgccacca tcaagaccaa gcgcaccatc cagtttgtgg     1140

attggtgccc gactggattt aaggtgggca ttaactacca gccccccaca gtggtccccg     1200

ggggagacct ggccaaggtg cagcgggccg tgtgcatgct gagcaacacc acggccattg     1260

cggaggcctg ggcccgcctg gaccataagt tcgatctcat gtatgccaag cgggcctttg     1320

tgcactggta cgtgggcgaa ggcatggaag agggagagtt ctctgaggcc cgcgaggacc     1380

tggcagctct agagaaggat tatgaagagg tgggcgtgga ttccgtggaa gctgaggctg     1440

aagaaggcga agaatactga ggggagggtg tggtgggttc tcccctgcca cccccgggat     1500

ggctgcttcc aagttgtttg caattaaagg ttctgtataa aaccaa                    1546


<210> 917
<211> 2169
<212> DNA
<213> Homo sapiens

<400> 917
aatgagatgc tcgcctccgc gcgtttccgc ttccgccatc gcggacgcag cctcgtgccg       60

ggagtcgccg cattgtggtc cgcttctctg cactatgtcg ggtggcctcc tgaaggcgct      120

gcgcagcgac tcctacgtgg agctgagcca gtaccgggac cagcacttcc ggggtgacaa      180

tgaagaacaa gaaaaattac tgaagaaaag ctgtacgtta tatgttggaa atctttcttt      240

ttacacaact gaagaacaaa tctatgaact cttcagcaaa agtggtgaca taaagaaaat      300

cattatgggt ctggataaaa tgaagaaaac agcatgtgga ttctgttttg tggaatatta      360

ctcacgcgca gatgcggaaa acgccatgcg gtacataaat gggacgcgtc tggatgaccg      420

aatcattcgc acagactggg acgcaggctt taaggagggc aggcaatacg gccgtgggcg      480

atctgggggc caggttcggg atgagtatcg gcaggactac gatgctggga gaggaggcta      540

tggaaaactg gcacagaacc agtgagtggt gagagctctg tcagtgacaa acactccttt      600

ggcctgttga atttgctgaa gaacatcacc taaagtctgc acacgagccc atttttacca      660

agatttgatc agtgtcttta ctgagctgga agcctctgaa agttattaaa ggacagaatc      720

caaaagaatg cctttaattc ttgtctgaga atcttggcca tgtgtcagat tatcagaaca      780

attttgttac caggtcagaa attgtgttct ttgacaacag attggatctg taatgttgat      840

tagtctttag ccataaccac tacactttta gaaagacaga aaaatgtaag aatttgtttt      900

taccataatg agtcttaagt aggttcatga tctacattgg ggcctgggat tattttttta      960

attttaagtt tgcatgagat agcctaataa atggaggtgg ggccaggcat ggtggctcac     1020

acgtgtaatc ccaacacttt gggaggctga ggaggaagga tagcttgagg ccaggagttt     1080

gagactagac tgggcaacat agcaagaccc cgtctctaca aagcacaacg aaaaacaaca     1140

aatggagttg tgctatgttg tattgctttg cacaaaatta ggaacaggtg tttgacaatt     1200

gaatttgttt tctgtgaatt ctaacctcta aaggcatgct tagaggtcaa ggaccttcct     1260

gtgtagttgg tgcaaaagca atctccacag gacagcactg cttccatgct tcatacatca     1320

ggaaatgagg ccagaacttg agtatttact aacacgtttt tcaaaagatg tcagtgttat     1380

acctaaagct aaaaaaaagc aagggtttgt catagaggga acctctaaat aatttcaggg     1440

gtaggggaga tgttgtcaat aggaaatggg ataaaatatc aagagacaat gaaaacactg     1500

ccttgacatg aggaccagca agtttattct tttcattttc agtgatgttg ggaatggact     1560

gggttttaaa agggagcttg aagagggaat gtttgacagt cacagaaggt tcctgcagca     1620

gatgcctctt ttagccattt ctcatttttt tcctcaaatt ttacctactg aggctcaagc     1680

cttcacagtg agctgatggt ctctacaggg aggggagtct agggaattta tttggtattt     1740

gtaaggcaag aggtgatttc tctctaatat atctgagtta ttgctcattt aaaactgtta     1800

agtccagtat aattttccct gatatgaaaa aatgtgcatt tttttcactt agcaacaaag     1860

taccttctaa tttccaatag tccgtgaaag ttggggctga agtacctaag tgtgaatgtc     1920

tctcccgtta aactgagtgt agaaatctga atttttaaaa gagctgtaac tagttgtaag     1980

tgcttaggaa gaaactttgc aaacatttaa tgaggataca ctgttcattt ttaaaattcc     2040

ttcacactgt aatttaatgt gttttatatt cttttgtagt aaaacaacat aactcagatt     2100

tctacaggag acagtggttt tattcggatt gtcttctgta ataggtttca ataaagctgg     2160

atgaactta                                                             2169


<210> 918
<211> 1800
<212> DNA
<213> Homo sapiens

<400> 918
gtgtttccgg ctccgctgcg gaaggcggac gactagagtc gttgggcccg gcgcgacccg       60

caggagcgta gagagcgcgg gactagagtg cagagctccg ggacgtggat cggagccggc      120

gcgatgggcg gagagcagga ggaggagcgg ttcgacggca tgttgctggc catggctcag      180

cagcacgagg gcggcgtgca ggagcttgtg aacaccttct tcagcttcct tcgacgcaaa      240

acagactttt tcattggagg agaagaaggg atggcagaga agcttatcac acagactttc      300

agccaccaca atcagctggc acagaagacc cggcgggaga agagagcccg gcaggaggcc      360

gagcggcggg agaaggcgga gcgggcggcc agactggcca aggaagccaa gtcagagacc      420

tcagggcccc agatcaagga gctaactgat gaagaggcag agaggctgca gctagagatt      480

gaccagaaaa aggatgcaga gaatcatgag gcccagctca agaacggcag ccttgactcc      540

ccagggaagc aggatactga ggaagatgag gaggaagatg agaaggacaa aggaaaactg      600

aagcccaacc taggcaacgg ggcagacctg cccaattacc gctggaccca gaccctgtcg      660

gagctggacc tggcggtccc tttctgtgtg aacttccggc tgaaagggaa ggacatggtg      720

gtggacatcc agcggcggca cctccgggtg gggctcaagg ggcagccagc gatcattgat      780

ggggagctct acaatgaagt gaaggtggag gagagctcgt ggctcattga ggacggcaag      840

gtggtgactg tgcatctgga gaagatcaat aagatggagt ggtggagccg cttggtgtcc      900

agtgaccctg agatcaacac caagaagatt aaccctgaga attccaagct gtcagacctg      960

gacagtgaga ctcgcagcat ggtggaaaag atgatgtatg accagcgaca gaagtccatg     1020

gggctgccaa cttcagacga acagaagaaa caggagattc tgaagaagtt catggatcaa     1080

catccggaga tggatttttc caaggctaaa ttcaactagc ccctgttttt tcctccctga     1140

actcttgggg ctgagctgca accacccaac tttctttccc actcttctct gggacttgtg     1200

ggcctcaggg cttggggcag gcatgggact ggcccaggca cacaggtccc ggggcatcag     1260

gagaaaggct gggtcttggg accttgtcct ccccagttgg cctactgtta cacattaaaa     1320

cgatttgccc agctccttct gtgtcctctc ttgcctctgg cctttctctg gggcacaggc     1380

ctcttacggc tgctgctggg aactgggagt ttggcttcta gcccagattc tgccatgtga     1440

cctagggcac atccttgccc ctctctgggc ctcagtttct cattacttaa agattaaaac     1500

aaggcttggc cgggtgtgat ggttcatgtc tgtaatccca gcactttggg aggctgaggg     1560

gagcagatca cctgatgtca ggagtttgag accagcttgg ccaacatgga gaaacccagt     1620

ctctactaaa aatacaaaaa ttagccgggt gtggtggtgc acacctgtaa tcccagctac     1680

tcgggaggct gaggcaggag aatcgcttga acccgggtgg cggaggttgc agtgagccga     1740

gattgcacta cttcactcca gcatgggtga cagagactcc atctcaaaaa aataaataaa     1800


<210> 919
<211> 2243
<212> DNA
<213> Homo sapiens

<400> 919
ccaaagccct cttgggacaa gccggggatt ccccgccgcc gcccgccccc tggcgtcacg       60

gagtccccgc gaggccccgc cccggcctgg cgccgtcctg ggcgggagga acgcgccgct      120

aggcgggaga gcgcggccat ggcggggccg ggcgtccccg gtgcccccgc agcgcgctgg      180

aaacgccaca tcgtgcggca gctgcggctt cgggaccgta cgcaaaaggc gcttttcctg      240

gagctggtgc cggcctataa ccatctctta gagaaggctg agctgctgga caagttctca      300

aagaagctgc agccggagcc aaacagtgtc actcccacca cccaccaggg cccctgggag      360

gagtcagagc ttgactcaga ccaagtccca tcactggtcg cactgagggt gaagtggcag      420

gaggaggagg aggggctccg gctggtctgt ggtgagatgg cctaccaggt ggtggagaag      480

ggcgcggccc tgggcacgct ggagtcggag ctgcagcaga ggcaaagcag gctggcagcc      540

ctggaggccc gcgtggcgca gctgcgagag gcgcgggcgc agcaggccca gcaggtggag      600

gagtggcggg cgcagaatgc ggtgcagcgg gcagcctacg aggcgctgcg cgcgcacgtc      660

gggctccggg aggcggcact gcgcaggctc caggaagagg cgcgcgacct gctggagagg      720

ctcgtgcagc gcaaggcgcg cgccgcggcc gagcgcaacc tgcgcaacga gcgccgggag      780

cgggccaagc aggcgcgggt gtcccaggag ctgaagaagg ctgccaagcg gaccgtgagc      840

atcagcgagg gcccggacac cctaggcgat gggatgaggg agagaaggga gactctggct      900

ctggcccctg agccagagcc cctggagaag gaagcttgtg agaagtggaa gaggcccttc      960

aggtctgcct cagccacctc cctgacgctg tcccactgtg tggatgtggt gaaggggctt     1020

ctggatttta agaagaggag aggtcactca attgggggag cccctgagca gcgataccag     1080

atcatccctg tgtgtgtggc tgcccgactt cctacccggg ctcaggatgt gctggatgcc     1140

cacctctctg aggtcaatgc tgttcgtttt ggccccaaca gcagcctcct ggccactgga     1200

ggggctgacc gcctgatcca cctctggaat gttgtgggaa gtcgcctgga ggccaaccag     1260

accctggagg gagctggtgg cagcatcacc agtgtggact ttgacccctc gggctaccag     1320

gttttagcag caacttacaa ccaggctgcc cagctctgga aggtggggga ggcacagtcc     1380

aaggagacac tgtctggaca caaggataag gtgacagctg ccaaattcaa gctaacgagg     1440

caccaggcag tgactgggag ccgcgaccgg acagtgaagg agtgggacct cggccgtgcc     1500

tattgctcca ggaccatcaa tgtcctttcc tactgtaatg acgtggtgtg tggggaccat     1560

atcatcatta gtggccacaa tgaccagaag atccggttct gggacagcag ggggccccac     1620

tgcacccagg tcatccctgt gcagggccgg gtcacctccc tgagcctcag ccacgaccaa     1680

ctgcacctgc tcagctgttc ccgagacaac acactcaagg tcatcgacct gcgtgtcagc     1740

aacatccgcc aggtgttcag ggccgatggc ttcaagtgtg gttctgactg gaccaaagct     1800

gtgttcagcc cggacagaag ctatgcactg gcaggctcct gtgatggggc cctttacatc     1860

tgggatgtgg acaccgggaa actggagagc agactacagg gaccccattg cgctgccgtc     1920

aacgccgtgg cctggtgcta ctccgggagc cacatggtga gcgtggacca gggcaggaag     1980

gttgtgctct ggcagtaggg ccacgacctg cctgcctggg ctggagctct tgcccgaagc     2040

ctgaagcttc cttcggcgcc atgcaggggt tggggttggg actggagctg gccttgggat     2100

ttaatgggga agaaggcctg gcaggacctg gcctgtttgt ttaaaaatga agtatgggtt     2160

gggggattac gctagttttt ctttgtattt ttatctctat ctcctcactt tttctcccaa     2220

agtagaaaaa aatgatatct gaa                                             2243


<210> 920
<211> 7550
<212> DNA
<213> Homo sapiens

<400> 920
ggaagcggaa gtgaagggtg cgcttggcgg cggcggcggg agctgcggag tcgggaatca       60

aaacaaaggg cctggggggg gcggggggaa ggcggcgggg ccggaatgtg agcggaggtg      120

gagccggcgg cagagggtgg aagaatgaaa gaaaagaaag atgaaaggat gttgaatcac      180

tttgcatggc tgtatgatgg aaggaaacgg aactgagaac tcctgcagta gaacacgtgg      240

atggcttcaa caagataatg atgctaagcc atggctttgg aaattctcta attgcttttc      300

tcgtcctgag cagacgctgc cacatagtcc ccaaacgaaa gagtacatgg agaacaagaa      360

agttgctgtg gaactaaagg atgtaccatc accccttcat gctggctcta agctttttcc      420

agcagtccca cttcctgata ttcgttctct tcagcagcct aaaatacagc tttcttctgt      480

ccccaaagta agctgctgtg ctcattgccc taatgaaccc tccacttcgc caatgcgttt      540

tggtggtggt ggtggcggta gcggaggtac cagtagcttg attcacccgg gcgcactgtt      600

agactcgcaa agcaccagga caatcacgtg tcaggtaggg tcagggtttg ctttccagtc      660

tgcatcttca ctccagaatg cctcagctag gaacaatttg gcaggcattg caagtgactt      720

tcccagcatg tgtctagaga gtaacctgtc ttcctgcaaa cacctgccct gttgtggaaa      780

actccacttc cagtcatgtc atggtaatgt gcacaagctg catcagtttc cgagtctgca      840

gggctgcacc tccgctggct atttcccctg ttctgatttc acaagcgggg ctccagggca      900

tttggaagag cacatttcac agtcggagct aacgcctcac ttgtgcacca actctttgca      960

ccttaatgtg gtacctccgg tttgtttaaa gggctcactt tactgcgaag actgtctaaa     1020

caagccagca agaaatagca taatcgatgc ggctaaagtc tggccaaata taccacctcc     1080

aaatactcaa cctgcacctc ttgctgtccc tctgtgtaat ggctgtggaa ccaaaggaac     1140

agggaaggag accacgttgt tattggcgac cagtctaggc aaagctgctt caaaatttgg     1200

gtcaccagaa gttgcagtag ctggacaggt gctagaaaac ttacccccca ttggagtttt     1260

ttgggatatt gaaaactgct ccgttccctc tggccggtca gcaactgctg ttgtgcaaag     1320

aatccgtgag aagtttttta aaggccacag agaagcagaa ttcatctgtg tatgtgacat     1380

cagtaaagaa aacaaggaag ttattcaaga gctgaataat tgccaggtaa ccgttgccca     1440

catcaatgct actgcaaaga atgccgctga tgataaactg cggcagagtc tccgcagatt     1500

tgcaaataca cacactgctc cagccacagt ggttcttgtg tcaactgatg tcaattttgc     1560

attggaactt agtgacctga gacacaggca tggtttccac attattttgg tccataaaaa     1620

ccaggcctca gaagcactgc tgcatcatgc taacgagctg atcagatttg aagagttcat     1680

ttccgacttg ccccccaggt taccactaaa aatgccacag tgccacactc tgctctatgt     1740

ttataaccta ccagcaaata aggatggcaa gagcgtcagc aacaggctca gacgcctgtc     1800

cgataattgt ggtgggaaag tgctgagtat cacaggctgc agtgcaattc tccgcttcat     1860

aaaccaagat agtgcagagc gcgctcagaa gcgaatggaa aacgaagatg tctttggtaa     1920

taggatcatt gtgtcattta ctccaaaaaa tagagaactc tgtgaaacaa agagttcaaa     1980

tgcaattgct gataaagtga agtctcccaa aaaacttaag aatccaaaat tgtgcctcat     2040

caaagatgca agtgaacaat cttccagtgc caaagccacg cctggaaaag ggtcacaggc     2100

aaattctgga tctgctacaa aaaatacaaa tgttaaaagt ttacaggagc tgtgccgcat     2160

ggagtcaaaa actggtcata gaaacagtga gcaccagcaa ggtcacctga ggctggtcgt     2220

acccactcac ggtaactcaa gtgctgcagt gtcgacgccg aaaaactcgg gggtggcaga     2280

acccgtttac aaaaccagtc agaaaaagga gaacctcagt gcccgaagtg ttaccagttc     2340

tcctgtagag aaaaaagata aagaggagac tgtattccaa gtgagttacc cgtctgcttt     2400

tagcaagtta gttgcatcca ggcaagtcag tcctctgctc gcatctcagt cttggtcttc     2460

taggagtatg tctccaaacc ttttaaacag agcatccccg cttgctttca acattgcaaa     2520

ttcgagcagc gaagccgact gcccagaccc atttgcaaat ggtgctgatg tccaagtcag     2580

caacatagac tacagattat cccggaagga gctgcagcag ctcctgcagg aagcatttgc     2640

caggcatggc aaggtgaaga gtgttgagct cagcccccat acagattatc aactcaaggc     2700

tgttgtgcaa atggaaaact tacaagatgc gatcggtgca gtgaatagcc tccacagata     2760

caaaattggc agcaaaaaga tcctggtctc acttgccacc ggggctgcca gcaaatcact     2820

ctctttactg agtgcagaaa caatgtctgt tcttcaggat gcccctgcct gttgcctgcc     2880

tctgtttaaa tttacagata tctatgaaaa aaagtttgga cacaagttga atgtgtcaga     2940

tctatataaa ttaacagaca cggtcgcaat ccgtgaacaa ggaaacggac ggctggtgtg     3000

tctcctaccc agcagtcagg cccgccagag ccccttgggg tcttcccagt cacacgacgg     3060

ctcctccacg aattgcagcc caattatatt tgaagagtta gaatatcacg agcctgtctg     3120

cagacagcat tgttccaata aggatttcag cgaacatgaa tttgatccag actcttacaa     3180

gattcctttt gtgattcttt ctttgaagac atttgcgccc caggttcaca gtcttctcca     3240

gacccacgag ggcaccgtgc ctttactaga cccttggctt ctgcgttcga agagtcctgt     3300

aggtaacccc cagctgatcc agttcagtag agaagtgatt gacttgctga aaagccagcc     3360

atcttgtgtc atacccatca gtcatttcat cccatcctat caccatcatt ttgcaaagca     3420

gtgccgagtg tcagactacg gatactccaa gctgattgag ttattagaag cagtgcctca     3480

tgtattgcag attcttggaa tgggctccaa acgtctgctg acccttaccc acagggccca     3540

ggtgaagcgc tttactcagg atttactaaa acttctcaaa tcccaggcca gcaaacaggt     3600

cattgtgaga gaattctcac aggcttatca ctggtgtttc tcaaaggact gggatgtcac     3660

tgaatatggt gtttgtgagt tgattgacat cgtatcagag attccagaca caaccatctg     3720

cttgtcccaa caagataatg aaatggtgat ttgtatcccc aaaagagaac gcactcagga     3780

tgaaatagaa aggacaaaac agttctccaa ggatgtcgtt gatttgctgc gtcaccaacc     3840

ccatttccgg atgcccttta ataaatttat cccttcttac catcaccact ttggccggca     3900

gtgcaaactt gcgtactatg ggtttaccaa actacttgaa ctttttgaag ccatacctga     3960

tactttacaa gtattggaat gtggagaaga aaagatcctt actctgacag aggtggagcg     4020

gttcaaagct ctagctgccc agtttgttaa actccttcgg tcccaaaaag ataactgcct     4080

tatgatgaca gatctcctta cagaatatgc taaaactttt ggttatacat ttcgtctcca     4140

agactatgat gtcagttcca tttcggcttt aactcagaaa ctctgccatg tcgtgaaggt     4200

tgccgatata gaatctggca gacagattca gctgatcaac cgaaagtctc tgcgatctct     4260

cactgcccag ttgctggtat tgttgatgtc ttgggaagga accacccatc tttctgttga     4320

ggagctcaag agacattacg aaagtaccca caacactccc cttaacccct gtgaatatgg     4380

attcatgacc ttgaccgaac tgctgaagag cctgccatac ttggttgagg ttttcactaa     4440

tgataagatg gaagaatgtg tgaagctcac aagtctgtat ttgtttgcaa agaatgtgcg     4500

gtctttactt catacttacc actaccagca gattttcctt catgagtttt ccatggccta     4560

taccaagtat gtcggagaaa ctctgcagcc caagacctac ggccacagca gcgtggagga     4620

gctcttggga gcaattccac aggtggtctg gataaaagga catggtcata agagaattgt     4680

agtgttaaaa aatgacatga aaagtcgttt gagttcactc agtctctccc ctgccaatca     4740

tgaaaaccag ccctcggagg gcgagcgcat cctggaggtg cccgaatcgc acacagcctc     4800

ggaactcaag cttggagctg acggcagtgg gcccagtcac acagagcagg agcttctccg     4860

cctgaccgac gactcccccg tcgacctcct gtgtgcgcct gtcccctcgt gcctgccgtc     4920

ccctcagctg agaccagacc ccgttatcct ccaatctgct gatctcattc agtttgagga     4980

gcgccctcaa gagccttctg aaattatgat tttaaaccaa gaagaaaaaa tggagattcc     5040

aataccagga aagagcaaaa ctctgacctc tgactccagc tcgtcctgca tctcagcagc     5100

tgtccccgtg cctccctgcc cctcctcgga aacctccgag tcactgctca gcaaggaccc     5160

cgtggaaagc ccggccaaaa agcaacccaa aaatagagtc aaattggcag ccaacttttc     5220

cttagcacct ataaccaagc tttaactccc atttggaata tagaattagg atgggaaaac     5280

actgtctgat tctgcacaca aaagtgggtt tcaaaaatac atccttttct gtgtcatgaa     5340

aaccccccga agccattgac ttcatcttac ctgtgttcta tcatgttttt cttttccatt     5400

gaacacagct ttgagctgaa gtctttcttt tcttcttcct ttttctttct tttttcaatt     5460

atttgaagaa cttgtggcat ttgttaaaga atccttaata tattttacca aatttttagt     5520

aactattatg aaatacaatg gtgttccaaa agaagaaagc actaaaaact caactagcag     5580

gaagcggttt tgcttccatt gagccacgtc ggtggtgtca tcctacatgt agcataatag     5640

agtctctcag cctttgctta ctggtgtttc cgacagtatt aacccagtgc gtggcatgtc     5700

tttgaagcaa agcctgtccc gctagcctgt gtgttcacac accaaaggag aagggtaggc     5760

gaggggttcg gagtgtattt tcaggttgga atgtgaaggt tcctggcttc catgtgactt     5820

gtaagtgtgc cttgtttttt atttaaacta tgtctgtagt tgacaaaagt ggcttcatca     5880

caaatttttt taaacgtttc tactttgggg ttccatttag gagctttcta gaaagttgag     5940

gatgtttgaa gcttcccttc tgtgttccag tttgatatgg gttaggttaa ggaaaaggag     6000

atggtctcga tgtcatggat ttaaagtcag catttggatt acaacacaca ttattgtgtg     6060

tcgagaggca gcattggaaa gagcctgatt ttctaaaata tgcatcaagt gcataaatta     6120

caaatcagag ctgagtgggg aggtgcttca gcagcagcgg gatcaatacg atttccactg     6180

ggaagagaca ggaattctac ctacacatag gaaggccaag gttgatccac ttaaccttgt     6240

tattgtaatt ttaaagctgg tatcggtagc tgggaagctt tatgtgtgtg tatgtcagct     6300

cagcatcttt taatcgtgtc tgattttact ctcgttactt ctcgctgttg gaagcatctc     6360

tgggtttctt gtggcgtctg gtgtggaatg gccttcctct ctaggtgcct gaggtgtccg     6420

ctgacgggtg gcctctcacc cccctctaga gaaacctgac atttacaatg gattgtattt     6480

gtccggcaaa aaaggcggat tcattcatag agcagaaaga acctgttggc gtaaggtctt     6540

ccactagtta gatggtttct tttggggaaa tgtttatatt tggtaacttc tagaaagcca     6600

gaaaatggac tctgatttca tagcattttg ataaaatgcc acaaaataag ggctatagag     6660

agatttttac aagtcagatt ttttgttccc caaatctttt aaatgaagcc agtgactccc     6720

agttctcaac acatggcccc agtcaagaca gaacaccatg gaaaaaaccc tgtaagtatt     6780

atggcactct ccgaatcctc ctgaaggcat ttcctctaca gacatagtgt tacaggaagt     6840

gaaatgcaaa tgtgcaattt tttttaaagg agcttttaaa caaagtaata ataattggtg     6900

ttgagaacat cagttgcctt attctaagat ttcataaggc tgagtttgca cgcttggact     6960

tcagttctgc tagcatgtaa agagtggtgg actttaaaac cgtaagaggt atcattacaa     7020

gtcacctgga acagactcaa agaacaggtt ctttgggcaa cagacaaaga agaatcaagt     7080

tctgtgctgt cccgtgagtg tgtctgagta ccattcactg gagttgctgc ttaggtctgg     7140

gacgtgtgtg tgactcttaa caattgctgt ctgaaaatga gagagaagac ttcggaagca     7200

cattgtgttc ataatgtact ccacaatggc cagtccaatt gctatctatt tttttatcca     7260

gaggcttaat taaatgatgt ggtaaaatga tgtttgagca ttaagacaat gtaattcttt     7320

atttctgggt ggaaagatat accggattaa atttatctgt ttaaaaaaat gacaaaagtt     7380

atcaccaaaa ccccctttcc catcttgcac tgtttgtttt ggattgggtt tgggggaaag     7440

agatgttttt cttagttgtc tactttgttt gaacactttt gttgtggttc aagtgctgtt     7500

ttgtgtgttg ggaccaaaca gttgtcaata aactttacaa gcgagcatct                7550


<210> 921
<211> 785
<212> DNA
<213> Homo sapiens

<400> 921
ggtggcgggt atgatctcaa cctcttcgcc agccctcctg acagcaactt cgtgtgctcc       60

gtctgccatg gggttctcaa gaggccagca aggttgccat gcagccacat cttctgcaaa      120

aagtgcatcc tccggtggct agccagacaa aagacctgtc cgtgctgtag gaaagaggtg      180

aaaaggaaaa aggttgtcca catgaataaa ctccggaaaa ccattggccg cctggaagtc      240

aagtgcaaga acgccgacgc tggctgcata gtgacatgcc ccctggccca tcgcaagggg      300

caccaggact catgcccctt tgagctaacg gcctgcccca acgagggctg cacctcgcag      360

gtgccgcgtg ggaccctggc agagcaccgg cagcattgcc agcaagggtc ccagcagcgc      420

tgccccctgg gctgcggggc caccctggac ccggccgagc gtgctcgcca caactgctac      480

cgggagctgc acaacgcctg gagcgtgcgc caggagcgcc gtcggcccct gctgctgtcc      540

ctcctgcggc gtgtgcgctg gctggaccaa gccaccagtg tcgttcgtag agagctggcg      600

gagctcagca acttcctgga ggaagacacc gctctgctgg agggtgcccc acaggaggag      660

gccgaggctg ccccagaagg caacgttggg gctgaggtgg tgggggagcc cagggccaac      720

ataccttgta aataggtaaa taaaagcaga cccccggcct gcctgcctct gtgcctgcgg      780

ccctc                                                                  785


<210> 922
<211> 882
<212> DNA
<213> Homo sapiens

<400> 922
gttgcctaaa cctctgccac ccacctgtga acttcacttt gccacaggga ggcactgaac       60

tgaaaaactg ccttgtaaga ggtgtcgccc ctctgtctac tccctttctt atatcaagag      120

gggaaaaaca cgtaactacc tctacccgat ctggtcacca tacgcctatt acctttactg      180

ttacaagtac cggatcactc tccgggagaa gatgctgcct cgttgttata aaagcatcac      240

ttataaggaa gaggaggact tgacactcca gccccgttcc tgcctccagt gcgagtccct      300

agtaggcctc caggagggca aaagcaccga gcagggtaac cacgaccagc ttaaagaact      360

gtattcggct gggaacttga cggtgctggc tactgacccc ctgctccacc aggacccagt      420

acagttagac tttcacttcc gccttacctc ccagacctct gcccattggc acggccttct      480

ctgtgaccgt cgactcttct tggatatccc atatcaggcc ttggatcaag gcaaccggga      540

aagtttgact gcaaccctgg agtacgtgga agagaagaca aatgtggact ctgtgtttgt      600

gaacttccag aatgatcgga acgacagagg tgccctgctg cgggccttca gctacatggg      660

ctttgaggtg gtcagaccag atcaccctgc cctccctccc ttggacaatg tcatctttat      720

ggtgtatccc cttgaaaggg atgttggcca cctgcccagt gagcctcctt gaacatgctt      780

attccaacgc tttgaggggc tggaagcctt gacacatgga atcaggggcc cgggatgtga      840

ttcaggacac tttccatcct aggaataaag ggtagtgcaa tc                         882


<210> 923
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 923
cgagtgttgg cggggactga gcctcctgct tgaggtagtt gtttttactc ccagtcccca       60

ggctcacgag ccccacgcgc gctcaatctg ccctcccgct tctcctcgcc actccgagtt      120

ctgcgccctc gagatccagc gcatccgcgg ggtgggcggg tcctggcggc tctttgccct      180

cttccaacat ggccgccgct gcctctgtga caggcagggt cacgtgggca gcctcgccta      240

tgaggtcgct ggggctcggc cggcgattgt cccttcccgg accccgtctc gatgcggtga      300

ctgccgctgt caacccgagc ctgagcgatc atggcaacgg gctcgggcgg ggaacgcgtg      360

gcagcggctg cagcggcggc agtttggtgg cggactgggg cggcggagcg gcggcggcgg      420

cggcggtggc actggcactg gccccggccc tgagcaccat gcggcggggc agctccgaga      480

gcgagctggc ggcccggtgg gaggcggagg cggtggctgc ggccaaagcg gcggccaaag      540

ctgaggccga ggccacagcg gagacggtgg cggaacaggt ccgcgtggac gcgggcgcgg      600

ccggggaacc ggagtgcaag gcaggggagg agcagcccaa ggtcctggcc ccggccccgg      660

cgcagcccag tgcggctgag gaggggaaca cccaggtcct tcagcggccg ccgcccacgc      720

tgcccccgtc caagccgaag ccggtgcagg gcctctgccc gcacgggaag ccccgggaca      780

agggccgaag ctgcaagcgg agctcgggcc acggttccgg cgagaacggc tcccagcggc      840

cggtcaccgt ggacagctcc aaggccagga cctccctgga tgccctgaag atcagcatcc      900

gccagctcaa gtggaaggag ttcccatttg gccggcgctt gccttgtgac atctactggc      960

atggagtttc atttcacgac aatgacatat tctccggtca agtgaacaag tttccaggca     1020

tgacggagat ggtgcgtaaa attactctga gcagagcagt gagaaccatg cagaatctct     1080

ttcctgagga gtacaacttc taccctcgct catggattct gcctgacgag ttccagctct     1140

ttgttgctca ggttcaaatg gtgaaagacg atgacccctc ctggaagccc acttttatcg     1200

tgaaacctga tggtggttgt cagggtgatg gaatctacct cattaaagac cccagtgaca     1260

tccgcctggc agggaccctc cagagcaggc cagcggtggt ccaggagtac atctgcaaac     1320

ctctccttat cgacaagctc aagtttgata ttcgtctgta tgtcttactc aagtccttag     1380

accccttaga gatttatata gccaaagacg gactctctag gttttgtacc gagccatatc     1440

aggagcccac ccccaaaaac ctgcaccgca tctttatgca cttaaccaac tattcactga     1500

acatccacag cggcaacttc atccactcgg acagtgctag cactggcagc aaaaggactt     1560

tttccagcat cctttgtaga ctgtcttcca aaggcgttga catcaagaag gtctggtctg     1620

acatcatctc cgtggtgatt aagacggtca tcgcgctgac tccagagctc aaagtcttct     1680

accagtcaga catccccacg gggaggccgg gccccacgtg cttccagatt ttaggctttg     1740

acattcttct aatgaaaaat ctgaagccta tactacttga agtaaatgca aatcccagta     1800

tgagaatcga acatgagcac gaactttctc caggggtgtt tgaaaatgtc cccagcctcg     1860

ttgatgaaga agtgaaagtg gctgtgatca gagacactct gcgcctcatg gacccactta     1920

agaagaaaag agagaatcag tctcagcagc ttgaaaaacc attcgctgga aaggaagatg     1980

ctttggacgg cgagctgacc agtgctccag actgcaacgc caaccccgaa gcccacctgc     2040

cttccatttg cctcaagcag gtgttcccca agtacgcaaa acagttcaac tacctgcgcc     2100

tggtggacag gatggcaaat ttgtttatcc ggttcctggg catcaagggg acaatgaagt     2160

tggggccaac aggctttcgt accttcataa ggagctgcaa actcagcagc agcagcctgt     2220

ccatggctgc cgtggacatc ctctacattg acatcacacg gaggtggaac tccatgaccc     2280

tggaccagcg ggactcaggg atgtgtctgc aggccttcgt agaagctttc tttttcctgg     2340

ctcagaggaa gttcaagatg ctgccacttc atgagcaggt ggcctcactg attgaccttt     2400

gcgagtacca cctgtccctg ctggatgaaa aacgcctggt gtgtggccgg ggcgtcccgt     2460

cggggggccg gcccccacac cgtggccctc cccaggagcc ctccccctcg gcccagccag     2520

caggggacaa ccccccaccc cgcaccagct gtgccaataa gctctcccat cccagacata     2580

ccctgtcctg agggccactc tgtcctcctg gaaaacggaa gacgagagca gctttcaggg     2640

ctggagcgcc ccaggcattc tgcctgcaga ggaatggcag gcaggctgcc gaggggccca     2700

gctgaggtcc ccacgaactg tctctgtgtg cggctgagct gtgcttcacc aggctggctg     2760

gttctcacct gccttcctcc tcacacctcc tggtgataca ccctgtttct gagtcatcag     2820

tcatcggaca tatgacatct aaaacgtgac agatggcacc ttctattctg ggctcacagg     2880

aagcaccaac tggggcaaat ctgttgtatt tggggcacag gacacaatcg atcccaaggc     2940

ccggagctgt ggagaggaag ccgagtgtta ggatctgctg ccggggcctc cacgcgccca     3000

ccgggaaaag cctgagaaca tcgtgtttat ttcctgccgc ccgttccgag agaaggaagt     3060

ggaaatatca agtaggcatc tgcgaatctc ccatcccagt catgtgctac atgggtgtag     3120

tgaacagatt aacctcattt agttcattag cttgcctgtt gctgcaatat ttggtttgtt     3180

attaattaag aaaaaattaa ttaagaagta actaagactc ctggagcctc agagctggca     3240

ggagcctcag                                                            3250


<210> 924
<211> 1081
<212> DNA
<213> Homo sapiens

<400> 924
actacttctc ccccggactc cttggtagtc tgttagtggg agatccttgt tgccgtccct       60

tcgcctcctt caccgccgca gaccccttca agttctagtc atgcgtgagt gcatctccat      120

ccacgttggc caggctggtg tccagattgg caatgcctgc tgggagctct actgcctgga      180

acacggcatc cagcccgatg gccagatgcc aagtgacaag accattgggg gaggagatga      240

ttccttcaac accttcttca gtgaaacggg tgctggcaag catgtgcccc gggcagtgtt      300

tgtagacttg gaacccacag tcattgatga agttcgcact ggcacttacc gccagctctt      360

ccaccctgag caactcatca caggcaagga agatgctgcc aataactatg cccgagggca      420

ctacaccatt ggcaaggaga tcattgacct cgtgttggac cgaattcgca agctgaaatc      480

attctttgca actaaacccc gcatccactt ccctctggcc acatatgccc ctgtcatctc      540

tgctgagaaa gcctaccacg aacagcttac tgtagcagag atcaccaatg cttgctttga      600

gccagccaac cagatggtga aatgtgaccc tcgccatggt aaatacatgg cttgctgcct      660

gttataccgt ggtgacgtgg ttcccaaaga tgtcaatgct gccattgcca ccatcaaaac      720

caagcgtacc atccagtttg tggattggtg ccccactggc ttcaaggttg gcattaatta      780

ccagcctccc actgtggtgc ctggcggaga cctggccaag gtacagagag ctgtgtgcat      840

gctgagcaat accacagctg ttgccgaggc ctgggctcgc ctggaccaca agtttgacct      900

gatgcccttg agaaggatta tgaggaggtt ggagcagata gtgctgacgg agaggatgag      960

ggtgaagagt attaacctgt gtgctgtact tttacactcc tttgtcttgg aactgtctta     1020

tttttgttct gtaaatgtct attgccgtaa attgttaata aaattgaagt ttccatttta     1080

a                                                                     1081


<210> 925
<211> 2103
<212> DNA
<213> Homo sapiens

<400> 925
gcagcggaag ccggaagcgg cgagcggggt cgttctgggc ctaggggagg cgggccgagg       60

gcgtctgagc tgaggcccgc gtcgatcctg ggttggagga ggtggcggcc gctgaggctg      120

cggcgtgaag acggcgggca tggtggggcg ggagaaagag ctctctatac actttgttcc      180

cgggagctgt cggctggtgg aggaggaagt taacatccct aataggaggg ttctggttac      240

tggtgccact gggcttcttg gcagagctgt acacaaagaa tttcagcaga ataattggca      300

tgcagttggc tgtggtttca gaagagcaag accaaaattt gaacaggtta atctgttgga      360

ttctaatgca gttcatcaca tcattcatga ttttcagccc catgttatag tacattgtgc      420

agcagagaga agaccagatg ttgtagaaaa tcagccagat gctgcctctc aacttaatgt      480

ggatgcttct gggaatttag caaaggaagc agctgctgtt ggagcatttc tcatctacat      540

tagctcagat tatgtatttg atggaacaaa tccaccttac agagaggaag acataccagc      600

tcccctaaat ttgtatggca aaacaaaatt agatggagaa aaggctgtcc tggagaacaa      660

tctaggagct gctgttttga ggattcctat tctgtatggg gaagttgaaa agctcgaaga      720

aagtgctgtg actgttatgt ttgataaagt gcagttcagc aacaagtcag caaacatgga      780

tcactggcag cagaggttcc ccacacatgt caaagatgtg gccactgtgt gccggcagct      840

agcagagaag agaatgctgg atccatcaat taagggaacc tttcactggt ctggcaatga      900

acagatgact aagtatgaaa tggcatgtgc aattgcagat gccttcaacc tccccagcag      960

tcacttaaga cctattactg acagccctgt cctaggagca caacgtccga gaaatgctca     1020

gcttgactgc tccaaattgg agaccttggg cattggccaa cgaacaccat ttcgaattgg     1080

aatcaaagaa tcactttggc ctttcctcat tgacaagaga tggagacaaa cggtctttca     1140

ttagtttatt tgtgttgggt tctttttttt ttttaaatga aaagtatagt atgtggcact     1200

ttttaaagaa caaaggaaat agttttgtat gagtacttta attgtgactc ttaggatctt     1260

tcaggtaaat gatgctcttg cactagtgaa attgtctaaa gaaactaaag ggcagtcatg     1320

ccctgtttgc agtaattttt ctttttatca ttttgtttgt cctggctaaa cttggagttt     1380

gagtatagta aattatgatc cttaaatatt tgagagtcag gatgaagcag atctgctgta     1440

gacttttcag atgaaattgt tcattctcgt aacctccata ttttcaggat ttttgaagct     1500

gttgaccttt tcatgttgat tattttaaat tgtgtgaaat agtataaaaa tcattggtgt     1560

tcattatttg ctttgcctga gctcagatca aaatgtttga agaaaggaac tttatttttg     1620

caagttacgt acagttttta tgcttgagat atttcaacat gttatgtata ttggaacttc     1680

tacagcttga tgcctcctgc ttttatagca gtttatgggg agcacttgaa agagcgtgtg     1740

tacatgtatt ttttttctag gcaaacattg aatgcaaacg tgtatttttt taatataaat     1800

atataactgt ccttttcatc ccatgttgcc gctaagtgat atttcatatg tgtggttata     1860

ctcataataa tgggccttgt aagtcttttc accattcatg aataataata aatatgtact     1920

gctggcatgt aatgcttagt tttcttgtat ttacttcttt ttttaaatgt aaggaccaaa     1980

cttctaaact aattgttctt ttgttgcttt aatttttaaa aattacattc ttctgatgta     2040

acatgtgata catacaaaag aatatagttt aatatgtatt gaaataaaac acaataaaat     2100

taa                                                                   2103


<210> 926
<211> 752
<212> DNA
<213> Homo sapiens

<400> 926
gccaaccggc tcccacatat ctgcacacac ttaaatacaa aggccgggaa gggtcagacc       60

accatccggg tactctaagt cctccctccc ccttctcctt cacccccaag tgtctcccac      120

gactgccctc cccgacctct agctgaccat ggcatcagag gcagaaaaaa cattccatcg      180

gtttgctgcg tttggagaat catcaagcag tggcactgaa atgaacaaca agaacttctc      240

caagctgtgc aaagactgtg gcatcatgga tggcaagaca gtcacctcca cggacgtgga      300

catcgtgttc agcaaagtca aggccaagaa cgcccgaacc atcacgtttc aacagttcaa      360

agaggcagtg aaggaactgg gccagaagcg cttcaaaggg aagagtccag atgaagtcct      420

ggagaacatt tatggactca tggagggcaa agacccagcc accactggcg ctactaaagc      480

aacaacagtg ggtgcagtgg accgtttgac agacaccagc aagtacaccg gcacccacaa      540

ggagcgcttt gatgagagtg gcaagggcaa gggcattgcg ggacgggaag agatgactga      600

caacacaggc tatgtgagtg gttacaaggg ttctggcacc tacgataaga agaccaagta      660

gagaggagct tcatctcagc ctgctagccc cctgaccctg catgtttaac accagggagc      720

ttggaaaaca ataaacatct gtgtgtgcag ca                                    752


<210> 927
<211> 4024
<212> DNA
<213> Homo sapiens

<400> 927
caggagggat ggactcctgg actctccagc tacctgcgtg gtcctccccg gtgtgaggac       60

agaagaccgg tcctgggccg ggcccgcatc cagccctacc gccggtgtct gaggtgaggg      120

ctccgtcagc ggaaaacgct cgacaacgga ggggcaggca gggccggggg cgtggtcaac      180

gcgggccccg ccccccgggc tctacccccg agcgtacgcg cgcgcctgaa gcagccaacc      240

aggaagcgca gagcaggttc aaacacagac ggcgggtgaa catggcgtcc tcgacttggt      300

ctgagacgtg ataggcctgc cttctggttg aagatgtggc gagtgaaaaa actgagcctc      360

agcctgtcgc cttcgcccca gacgggaaaa ccatctatga gaactcctct ccgtgaactt      420

accctgcagc ccggtgccct caccaactct ggaaaaagat cccccgcttg ctcctcgctg      480

accccatcac tgtgcaagct ggggctgcag gaaggcagca acaactcatc tccagtggat      540

tttgtaaata acaagaggac agacttatct tcagaacatt tcagtcattc ctcaaagtgg      600

ctagaaactt gtcagcatga atcagatgag cagcctctag atccaattcc ccaaattagc      660

tctactccta aaacgtctga ggaagcagta gacccactgg gcaattatat ggttaaaacc      720

atcgtccttg taccatctcc actggggcag caacaagaca tgatatttga ggcccgttta      780

gataccatgg cagagacaaa cagcatatct ttaaatggac ctttgagaac agacgatctg      840

gtgagagagg aggtggcacc ctgcatggga gacaggtttt cagaagttgc tgctgtatct      900

gagaaaccta tctttcagga atctccgtcc catctcttag aggagtctcc accaaatccc      960

tgttctgaac aactacattg ctccaaggaa agcctgagca gtagaactga ggctgtgcgt     1020

gaggacttag taccttctga aagtaacgcc ttcttgcctt cctctgttct ctggctttcc     1080

ccttcaactg ccttggcagc agatttccgt gtcaatcatg tggacccaga ggaggaaatt     1140

gtagagcatg gagctatgga ggaaagagaa atgaggtttc ccacacatcc taaggagtct     1200

gaaacagaag atcaagcact tgtctcaagt gtggaagata ttctgtccac atgcctgaca     1260

ccaaatctag tagaaatgga atcccaagaa gctccaggcc cagcagtaga agatgttggt     1320

aggattcttg gctctgatac agagtcttgg atgtccccac tggcctggct ggaaaaaggt     1380

gtaaatacct ccgtcatgct ggaaaatctc cgccaaagct tatcccttcc ctcgatgctt     1440

cgggatgctg caattggcac tacccctttc tctacttgct cggtggggac ttggtttact     1500

ccttcagcac cacaggaaaa gagtacaaac acatcccaga caggcctggt tggcaccaag     1560

cacagtactt ctgagacaga gcagctcctg tgtggccggc ctccagatct gactgccttg     1620

tctcgacatg acttggaaga taacctgctg agctctcttg tcattctgga ggttctctcc     1680

cgccagcttc gggactggaa gagccagctg gctgtccctc acccagaaac ccaggacagt     1740

agcacacaga ctgacacatc tcacagtggg ataactaata aacttcagca tcttaaggag     1800

agccatgaga tgggacaggc cctacagcag gccagaaatg tcatgcaatc atgggtgctt     1860

atctctaaag agctgatatc cttgcttcac ctatccctgt tgcatttaga agaagataag     1920

actactgtga gtcaggagtc tcggcgtgca gaaacattgg tctgttgctg ttttgatttg     1980

ctgaagaaat tgagggcaaa gctccagagc ctcaaagcag aaagggagga ggcaaggcac     2040

agagaggaaa tggctctcag aggcaaggat gcggcagaga tagtgttgga ggctttctgt     2100

gcacacgcca gccagcgcat cagccagctg gaacaggacc tagcatccat gcgggaattc     2160

agaggccttc tgaaggatgc ccagacccaa ctggtagggc ttcatgccaa gcaagaagag     2220

ctggttcagc agacagtgag tcttacttct accttgcaac aagactggag gtccatgcaa     2280

ctggattata caacatggac agctttgctg agtcggtccc gacaactcac agagaaactc     2340

acagtcaaga gccagcaagc cctgcaggaa cgtgatgtgg caattgagga aaagcaggag     2400

gtttctaggg tgctggaaca agtctctgcc cagttagagg agtgcaaagg ccaaacagaa     2460

caactggagt tggaaaacag tcgtctagca acagatctcc gggctcagtt gcagattctg     2520

gccaacatgg acagccagct aaaagagcta cagagtcagc atacccattg tgcccaggac     2580

ctggctatga aggatgagtt actctgccag cttacccaga gcaatgagga gcaggctgct     2640

caatggcaaa aggaagagat ggcactaaaa cacatgcagg cagaactgca gcagcaacaa     2700

gctgtcctgg ccaaagaggt gcgggacctg aaagagacct tggagtttgc agaccaggag     2760

aatcaggttg ctcacctgga gctgggtcag gttgagtgtc aattgaaaac cacactggaa     2820

gtgctccggg agcgcagctt gcagtgtgag aacctcaagg acactgtaga gaacctaacg     2880

gctaaactgg ccagcaccat agcagataac caggagcaag atctggagaa aacacggcag     2940

tactctcaaa agctagggct gctgactgag caactacaga gcctgactct ctttctacag     3000

acaaaactaa aggagaagac tgaacaagag acccttctgc tgagtacagc ctgtcctccc     3060

acccaggaac accctctgcc taatgacagg accttcctgg gaagcatctt gacagcagtg     3120

gcagatgaag agccagaatc aactcctgtg cccttgcttg gaagtgacaa gagtgctttc     3180

acccgagtag catcaatggt ttcccttcag cccgcagaga ccccaggcat ggaggagagc     3240

ctggcagaaa tgagtattat gactactgag cttcagagtc tttgttccct gctacaagag     3300

tctaaagaag aagccatcag gactctgcag cgaaaaattt gtgagctgca agctaggctg     3360

caggcccagg aagaacagca tcaggaagtc cagaaggcaa aagaagcaga catagagaag     3420

ctgaaccagg ccttgtgctt gcgctacaag aatgaaaagg agctccagga agtgatacag     3480

cagcagaatg agaagatcct agaacagata gacaagagtg gcgagctcat aagccttaga     3540

gaggaggtga cccaccttac ccgctcactt cggcgtgcgg agacagagac caaagtgctc     3600

caggaggccc tggcaggcca gctggactcc aactgccagc ctatggccac caattggatc     3660

caggagaaag tgtggctctc tcaggaggtg gacaaactga gagtgatgtt cctggagatg     3720

aaaaatgaga aggaaaaact catgatcaag ttccagagcc atagaaatat cctagaggag     3780

aaccttcggc gctctgacaa ggagttagaa aaactagatg acattgttca gcatatttat     3840

aagaccctgc tctctattcc agaggtggtg aggggatgca aagaactaca gggattgctg     3900

gaatttctga gctaagaaac tgaaagccag aatctgcttc acctcttttt acctgcaata     3960

cccccttacc ccaataccaa gaccaactgg catagagcca actgagataa atgctattta     4020

aata                                                                  4024


<210> 928
<211> 11292
<212> DNA
<213> Homo sapiens

<400> 928
cgccccccct gcgcccgccc ctcccccttc gctttccttc tccccccgcc tcggctccga       60

catgaggggc cggcggggca ggccgcccaa gcagcccgcg gctcccgctg cggagcgctg      120

cgccccggcc ccgccgccac cgccgccgcc gcccacgtcc ggacccatcg gggggctccg      180

ctcgcggcac cgcggcagca gccggggcag gtgggccgcc gcccaggctg aggtggcgcc      240

caagacgcgg ctgagctcgc ccaggggggg cagcagtagc cggaggaagc cgccgccgcc      300

gccgccggcc ccccccagca ccagcgcccc gggccggggg gggcgaggag gcgggggcgg      360

caggacgggg ggcgggggcg gcggcggcca cctggcccgg accaccgcgg cccggagggc      420

cgtcaacaaa gtggtgtacg atgaccacga gagcgaggag gaggaggaag aggaggacat      480

ggtctccgag gaggaggagg aggaggacgg cgacgccgag gagacccagg attctgagga      540

cgacgaggag gatgagatgg aagaggacga cgatgactcc gattatccgg aggagatgga      600

agacgacgac gacgacgcca gttactgcac ggaaagcagc ttcaggagcc atagtaccta      660

cagcagcact ccaggtaggc gaaaaccaag agtacatcgg cctcgttctc ctatattgga      720

agaaaaagac atcccgcccc ttgaatttcc caagtcctct gaggatttaa tggtgcctaa      780

tgagcatata atgaatgtca ttgccattta cgaggtactg cggaactttg gcactgtttt      840

gagattatct ccttttcgct ttgaggactt ttgtgcagct ctggtgagcc aagagcagtg      900

cacactcatg gcagagatgc atgttgtgct tttgaaagca gttctgcgtg aagaagacac      960

ttccaatact acctttggac ctgctgatct gaaagatagc gttaattcca cactgtattt     1020

catagatggg atgacgtggc cagaggtgct gcgggtgtac tgtgagagtg ataaggagta     1080

ccatcacgtt cttccttacc aagaggcaga ggactaccca tatggaccag tagagaacaa     1140

gatcaaagtt ctacagtttc tagtcgatca gtttcttaca acaaatattg ctcgagagga     1200

attgatgtct gaaggggtga tacagtatga tgaccattgt agggtttgtc acaaacttgg     1260

ggatttgctt tgctgtgaga catgttcagc agtataccat ttggaatgtg tgaagccacc     1320

tcttgaggag gtgccagagg acgagtggca gtgtgaagtc tgtgtagcac acaaggtgcc     1380

tggtgtgact gactgtgttg ctgaaatcca aaaaaataaa ccatatattc gacatgaacc     1440

tattggatat gatagaagtc ggaggaaata ctggttcttg aaccgaagac tcataataga     1500

agaagataca gaaaatgaaa atgaaaagaa aatttggtat tacagcacaa aggtccaact     1560

tgcagaatta attgactgtc tagacaaaga ttattgggaa gcagaactct gcaaaattct     1620

agaagaaatg cgtgaagaaa tccaccgaca catggacata actgaagacc tgaccaataa     1680

ggctcggggc agtaacaaat cctttctggc ggcagctaat gaagaaattt tggaatccat     1740

aagagccaaa aagggagaca ttgataatgt taaaagccca gaagaaacag aaaaagacaa     1800

gaatgagact gagaatgact ctaaagatgc tgagaaaaac agagaagaat ttgaagacca     1860

gtcccttgaa aaagacagtg acgacaaaac accagatgat gaccctgagc aaggaaaatc     1920

tgaggagcca acagaagttg gggataaagg taactctgtg tcagcaaatc ttggcgacaa     1980

cacaacaaat gcaacttcag aagagactag tccctctgaa gggaggagcc ctgtggggtg     2040

tctctcagaa acccccgata gcagcaacat ggcagagaag aaggtggcat ctgagctccc     2100

ccaggatgtg ccagaagaac ctaacaagac atgtgagagc agtaacacta gtgctaccac     2160

tacctccatc cagcctaatc tggaaaacag taacagcagc agtgaactaa attcttccca     2220

gagtgaatct gctaaggcag ctgatgatcc tgaaaatgga gaaagagaat ctcatacacc     2280

tgtctctatt caggaagaga tagtaggtga tttcaaatcg gagaagtcca acggggagct     2340

aagtgaatct cctggagctg gaaaaggagc atctggctca actcgaatca tcaccagatt     2400

gcggaatcca gatagcaaac ttagtcagct gaagagccag caggtggcag ccgctgcaca     2460

tgaagcaaat aaattattta aggagggcaa agaggtactg gtagttaact ctcaaggaga     2520

aatttcacgg ttgagcacca aaaaggaagt gatcatgaaa ggaaatatca acaattattt     2580

taaattgggt caagaaggga agtatcgcgt ctaccacaat caatactcca ccaattcatt     2640

tgctttgaat aagcaccagc acagagaaga ccatgataag agaaggcatc ttgcacataa     2700

gttctgtctg actccagcag gagagttcaa atggaacggt tctgtccatg ggtccaaagt     2760

tcttaccata tctactctga gactgactat cacccaatta gaaaacaaca tcccttcatc     2820

ctttcttcat cccaactggg catcacatag ggcaaattgg atcaaggcag ttcagatgtg     2880

tagcaaaccc agagaatttg cattggcttt agccattttg gagtgtgcag ttaaaccagt     2940

tgtgatgcta ccaatatggc gagaatcttt aggacatacc aggttacacc ggatgacatc     3000

aattgaaaga gaagaaaagg agaaagtcaa aaaaaaagag aagaaacagg aagaagaaga     3060

aacgatgcag caagcgacat gggtaaaata cacatttcca gttaagcatc aggtttggaa     3120

acaaaaaggt gaagagtaca gagtgacagg atatggtggt tggagctgga ttagtaaaac     3180

tcatgtttat aggtttgttc ctaaattgcc aggcaatact aatgtgaatt acagaaagtc     3240

gttagaagga accaaaaata atatggatga aaatatggat gagtcagata aaagaaaatg     3300

ttcacgaagt ccaaaaaaaa taaaaataga gcctgattct gaaaaagatg aggtaaaagg     3360

ttcagatgct gcaaaaggag cagaccaaaa tgaaatggat atctcaaaga ttactgagaa     3420

gaaggaccaa gatgtgaagg agctcttaga ttctgacagt gataaaccct gcaaggaaga     3480

accaatggaa gtagacgatg acatgaaaac agagtcacat gtaaattgtc aggagagttc     3540

tcaagtagat gtggtcaatg ttagtgaggg ttttcatcta aggactagtt acaaaaagaa     3600

aacaaaatca tccaaactag atggacttct tgaaaggaga attaaacagt ttacactgga     3660

agaaaaacag cgactcgaaa aaatcaagtt ggagggtgga attaagggta taggaaagac     3720

ttctacaaat tcttcaaaaa atctctctga atcaccagta ataacgaaag caaaagaagg     3780

gtgtcagagt gactcgatga gacaagaaca gagcccaaat gcaaataatg atcaacctga     3840

ggacttgatt cagggatgtt cagaaagtga ttcctcagtt cttagaatga gtgatcctag     3900

tcataccaca aacaaacttt atccaaaaga tcgagtgtta gatgatgtct ccattcggag     3960

cccagaaaca aaatgtccga aacaaaattc cattgaaaat gacatagaag aaaaagtctc     4020

tgaccttgcc agtagaggcc aggaacccag taagagtaaa acaaaaggaa atgatttttt     4080

catcgatgac tctaaactag ccagtgcaga tgatattggt actttgatct gtaagaacaa     4140

aaaaccgctc atacaggagg aaagtgacac cattgtttct tcttccaaga gtgctttaca     4200

ttcatcagtg cctaaaagta ccaatgacag agatgccaca cctctgtcaa gagcaatgga     4260

ctttgaagga aaactgggat gtgactctga atctaatagc actttggaaa atagttctga     4320

taccgtgtct attcaggata gcagtgaaga agatatgatt gttcagaata gcaatgaaag     4380

catttctgaa cagttcagaa ctcgagaaca agatgttgaa gtcttggagc cgttaaagtg     4440

tgagttggtt tctggtgagt ccactggaaa ctgtgaggac aggctgccgg tcaaggggac     4500

tgaagcaaat ggtaaaaaac caagtcagca gaagaaatta gaggagagac cagttaataa     4560

atgtagtgat caaataaagc taaaaaatac cactgacaaa aagaataatg aaaatcgaga     4620

gtctgaaaag aaaggacaga gaacaagtac atttcaaata aatggaaaag ataataaacc     4680

caaaatatat ttgaaaggtg aatgcttgaa agaaatttct gagagtagag tagtaagtgg     4740

taatgttgaa ccaaaggtta ataatataaa taaaataatc cctgagaatg atattaaatc     4800

attgactgtt aaagaatctg ctataaggcc attcattaat ggtgatgtca tcatggaaga     4860

ttttaatgaa agaaacagct ccgaaacaaa atcgcatttg ctgagttctt cagatgctga     4920

aggtaactac cgagatagcc ttgagaccct gccatcaacc aaagagtctg acagtacaca     4980

gacgaccaca ccctcagcat cttgtccaga aagcaattca gttaatcagg tagaagatat     5040

ggaaatagaa acctcagaag ttaagaaagt tacttcatca cctattactt ctgaagagga     5100

atctaatctc agtaatgact ttattgatga aaatggtctg cccatcaaca aaaatgaaaa     5160

tgtcaatgga gaatctaaaa gaaaaaccgt catcacagaa gtcaccacga tgacctccac     5220

agtggccaca gaatcaaaaa ctgtgatcaa ggtagaaaaa ggcgataagc aaactgtggt     5280

ttcttccaca gaaaattgtg caaaatccac tgtcacaacc accactacaa cagtgaccaa     5340

gctttccaca ccctccacag gcggcagtgt ggacatcatc tctgtaaagg agcagagcaa     5400

aaccgtggtc accacgacag tgacagactc cctgaccacc acgggaggca cactggttac     5460

atctatgact gtgagcaaag agtattccac acgagacaaa gtgaaactga tgaaattttc     5520

aagaccaaag aagactcgtt caggtacagc tctgccatcc tatagaaaat ttgttaccaa     5580

gagcagcaag aagagcattt ttgttttgcc taatgatgac ttaaaaaagt tggcccgaaa     5640

aggaggaatc cgagaggtcc cttattttaa ttacaatgca aaacctgctt tggatatatg     5700

gccatatcct tctcctagac cgacctttgg catcacttgg aggtatagac ttcagacagt     5760

aaagtcctta gctggagtga gcctgatgtt acggttactg tgggcaagtt tgagatggga     5820

tgatatggcg gccaaggctc ctccaggagg agggactaca cggacagaaa catccgaaac     5880

tgaaatcaca acaacagaaa taattaagag gagagatgtt ggtccttatg gcattcgatc     5940

tgaatattgt atcaggaaaa tcatttgtcc cattggagtt ccagaaacac caaaagaaac     6000

gcctacacct cagaggaaag gccttcgatc aagtgcactg cggccaaaga gaccagaaac     6060

gcccaagcaa actggccctg ttattattga aacctgggta gcagaagaag aactggaatt     6120

gtgggagatc agggcatttg ctgagagagt ggagaaagaa aaggcacaag cagttgagca     6180

acaggctaag aaacgactgg agcagcagaa gccgacagtg attgcaactt ccactacttc     6240

cccaacaagc agtacaacca gcaccatctc tccagcacag aaggttatgg tggcccccat     6300

aagtggctca gttacaactg gaaccaaaat ggtactaact actaaagttg gatctccagc     6360

tacagtaaca ttccaacaaa acaagaactt tcatcaaacc tttgctacat gggttaagca     6420

aggccagtca aattcaggcg ttgttcaagt acagcagaaa gtcctgggta tcattccatc     6480

aagtacaggt accagtcagc aaacctttac ttcattccag cccaggacag caacagtcac     6540

aattaggccc aatacctcag gctctggagg aaccacaagc aattcacaag taatcacagg     6600

gcctcagatt cgccctggta tgaccgtgat tagaacacca ctccaacagt caacactagg     6660

aaaggcaatt attcgaacac ctgtgatggt acagccaggt gctcctcagc aagtgatgac     6720

tcaaatcatc agggggcagc ctgtctccac tgcagtctcc gcccctaaca cggtttcctc     6780

aacacctggg cagaaaagct taacttcagc aacgtccact tcaaatatac agtcttcagc     6840

ctcacaaccc cctcgccccc aacaaggaca agtgaagctc accatggctc aacttactca     6900

gttaacacag ggccacggtg gcaatcaagg tttgacagta gtaattcaag gacaaggtca     6960

aactactgga cagttgcagt tgatacctca aggggtgact gtactcccag gcccaggcca     7020

gcagctaatg caagctgcaa tgccaaatgg tactgttcag cgattcctct ttaccccatt     7080

ggcaacaaca gccaccacag ccagcaccac caccaccact gtttccacga cagcagcagg     7140

tacaggtgaa caaaggcaga gtaaactgtc accccagatg caggtacatc aagacaaaac     7200

cctgccacca gctcagtcat caagtgtggg tccagcagaa gcccagccac agactgctca     7260

gccttcagct cagccccagc cccaaaccca gccccagtcc ccagctcagc ctgaagttca     7320

gactcagcct gaagttcaga cccaaacaac tgtttcatcc catgtccctt ctgaagcaca     7380

acccacccac gcacagtcat ccaagcccca agttgcagca cagtctcagc ctcaaagtaa     7440

tgtccaagga cagtctcctg ttcgtgtcca aagtccatca cagactcgaa tacgtccatc     7500

aactccatcc caactgtctc ctggacaaca atcccaggtt cagactacaa cctcacaacc     7560

gattccaatt caaccacata catctcttca gataccttcc caaggccagc cacagtcaca     7620

accccaggta cagtcttcaa ctcaaactct ttcatcagga caaactttaa atcaagttac     7680

tgtttcatcc ccatcccgtc ctcagctaca aatacagcag ccacagcccc aagtcattgc     7740

tgtgcctcag ctgcaacaac aagtccaggt tctctctcag atccagtcac aggttgtggc     7800

tcagatacag gctcagcaaa gtggtgtgcc ccagcaaatc aaactccagt tacctatcca     7860

aattcagcaa agcagtgctg tgcagactca ccagattcag aatgtggtta cagtgcaggc     7920

agccagtgtg caagagcagt tgcaaagggt tcagcaactc agggatcagc agcaaaagaa     7980

gaaacagcaa cagatagaaa ttaagcgtga acacaccctc caagcttcta atcaaagtga     8040

aatcattcag aaacaggtgg tgatgaagca taatgctgta atagaacatt taaaacagaa     8100

aaagagcatg actccagctg aaagagaaga gaatcaaaga atgattgtct gtaaccaggt     8160

gatgaagtat attttggata agatagataa agaagaaaaa caggcagcaa aaaaacggaa     8220

gcgtgaagag agtgtggagc agaaacgtag caagcagaat gccactaagc tgtcagctct     8280

gctcttcaag cacaaagagc agctcagagc cgagatcctg aagaagagag cactcctgga     8340

caaggatctg caaattgaag tgcaggaaga gctgaagaga gacctgaaaa ttaagaaaga     8400

aaaagacctg atgcagttgg ctcaggccac agcagtagct gcaccctgcc ccccagtgac     8460

accagctcct ccagcccctc cagcccctcc accttcacct ccccctccac ctgctgtgca     8520

acacacaggc cttctgtcca cgcccacctt acctgctgct tcccagaaga ggaagcggga     8580

agaggaaaaa gactccagct caaagtccaa gaaaaagaaa atgatctcta ctacctcaaa     8640

ggaaactaag aaggacacaa agctttactg tatctgtaaa acgccttatg atgaatctaa     8700

attttatatt ggctgtgatc ggtgtcagaa ttggtaccat gggcgctgcg ttggcatctt     8760

gcaaagtgag gcagagctca ttgatgagta tgtctgtcca cagtgccagt caacagagga     8820

tgccatgaca gtgctcacgc cactaacaga gaaggattat gaggggttga agagggtgct     8880

ccgttcctta caggcccata agatggcctg gcctttcctt gaaccagtag accctaatga     8940

tgcaccagat tattatggtg ttattaagga acctatggac cttgccacca tggaagaaag     9000

agtacaaaga cgatattatg aaaagctgac ggaatttgtg gcagatatga ccaaaatttt     9060

tgataactgt cgttactaca atccaagtga ctccccattt taccagtgtg cagaagttct     9120

cgaatcattc tttgtacaga aattgaaagg cttcaaagct agcaggtctc ataacaacaa     9180

actgcagtct acagcttctt aaagttcagc gtgttaacct aacataaaac acagcaagaa     9240

tctggttgtc tgaactattt taaattaagg agccagatgt ttttagtcag gctatcctga     9300

caagacttga cctaaacttc gtttttattg gtcataacag tccaattata ttcttggcca     9360

attttgtcca acggacaaga aaaaagcaaa gtcaacgaca ccattatctt gtcaagatca     9420

gatggtttta ctattgtggc agaagcgaga aaactttgtt tattgaaaaa aaaagaaaaa     9480

gaaagcaaga aaaaaagata ctatggggtc aagtgtaact ccatggaaat gccacgtctg     9540

ctcttcagtg aagaagctgg tttagagtct cacagaaaac ttttgactgt atttatttat     9600

tgttgcaaaa aagacgcttt tttattgctg ccctcatttg tcagctaatt attttttctt     9660

ataaaatcca gccccggtta catataatca tctgtatctt atcatgattc ctgtaggtaa     9720

aagtacaaga cgacctctag atgtcttttc tttctatgaa aggagctgct atgtacacat     9780

gtgcacacac acacaactgg gaatcaacaa tgagtttatt gttcatggta gattaaaatt     9840

aagcttgcat aaaggttggg ctaagtggtc ctggactaca gactctgttg ccttgaatat     9900

aacagtacaa tttgtcaatt actctgcacc aggctaaaat gagtaaaatc tatttgaagg     9960

tatcttgttt gtaaacattt gtcagattct aatttttttc ttttgtatta aaattcaact    10020

atggatgtat atgaaacaaa ataaatggag ataatttttc tcccacagac agaggtgtct    10080

ttgaatgtgc gctaatgatt atctgtaagc ctttgtgggg agggaggcct gcaaggtcat    10140

gaaaggcaga agagtctaat tgtgcctgga tttctccagg acagcagtgg cccctcgttt    10200

tatcattccc agtccattgt catcacgtca gagaaaaatc ttcaggggtg ctaatcctgt    10260

tgcatcagtt gatcatacta acgagaacgg taatgcgaca agatacacat tgccttcatc    10320

tgtacattct gtgataccag gcaaattacc aattacacac agctacttat attttatgaa    10380

gggcattttt tagatgacct catcctctgt gttatttgtt gattgggttt gttttctgtt    10440

tgttggtttg tttgtttctt ccacgtaagg aaaagtagtg taaacagtag cgagaaaatg    10500

gaaaccacag aggaagatgt attttgcatg tttttccttt cagtgttctt acacgttgta    10560

tcactgcatt gtggtaatag cttctataaa atctgccata gttggattat gcagctttgc    10620

aaaaattttt actagatttt gcactaactc atattagctt tgtcctacca acttctggaa    10680

tttatctaat tattgttttt caaagtttct ttccttttaa tgtttccctg ctatgcaaaa    10740

cctttcccag acctcagttt cttaaaagaa agatgttgct acagttcccg attctttctt    10800

attacaggct caggtgtaca ggttattctg ggttaatttt atctaatgaa gcccattcct    10860

ttttgtacat aaagatgtca cttaaactta tgcttacaaa ctaaagacta atcgctcaat    10920

atgaaaacat gaaaaaattt ttgcttaaag tattaagatg gaagtagtta aatatgggtt    10980

attttgtcct tttacttttt taaaaaatgt tacatattgt atgcactgtg ctgatgcaag    11040

aattctacat tttaatgagt tataaaatta ttctgcatct catcacgtca cagtatttct    11100

gtactattta ttcatatata taaatatata tgggcttaat catttaaaat ttgttgcagc    11160

aagaactttc ctacctgtag gcaatagatt gctatgtttt taacaaattg tggcaaattc    11220

taaacagcaa ttcttttgta cgtaatagga catttcatcc tagaaaaata aagtaatgtt    11280

tttgacattg ga                                                        11292


<210> 929
<211> 2461
<212> DNA
<213> Homo sapiens

<400> 929
gcgcgcagtt tcccgcatgc tcagtagctg aggtagggat gccatccttc tcaaaagact       60

tattgacagt gccaaagctc ggtactggac acaacgaggg acctgggtct acgataacgc      120

gcttttgctc ctcctgaagt gtctttggtc caacgttgtt ccagagtgta ccatggcttc      180

cagtaacact gtgttgatgc ggttggtagc ctccgcatat tctattgctc aaaaggcagg      240

aatgatagtc agacgtgtta ttgctgaagg agacctgggt attgtggaga agacctgtgc      300

aacagacctg cagaccaaag ctgaccgatt ggcacagatg agcatatgtt cttcattggc      360

ccggaaattc cccaaactca caattatagg ggaagaggat ctgccttctg aggaagtgga      420

tcaagagctg attgaagaca gtcagtggga agaaatactg aagcaaccat gcccatcgca      480

gtacagtgct attaaagaag aagatctcgt ggtctgggtt gatcctctgg atggaaccaa      540

ggaatatacc gaaggtcttc ttgacaatgt aacagttctt attggaattg cttatgaagg      600

aaaagccata gcaggagtta ttaaccagcc atattacaac tatgaggcag gaccagatgc      660

tgtgttgggg aggacaatct ggggagtttt aggtttaggc gcctttgggt ttcagctgaa      720

agaagtccct gctgggaaac acattatcac aactactcga tcccatagca acaagttggt      780

tactgactgt gttgctgcta tgaaccccga tgctgtgctg cgagtaggag gagcaggaaa      840

taagattatt cagctgattg aaggcaaagc ctctgcttat gtatttgcaa gtcctggttg      900

taagaagtgg gatacttgtg ctccagaagt tattttacat gctgtgggag gcaagttaac      960

cgatatccat gggaatgttc ttcagtacca caaggatgtg aagcatatga actctgcagg     1020

agtcctggcc acactgagga attatgacta ctatgcaagc cgagttccag aatctattaa     1080

aaatgcactt gttccttaaa ggaaagtttc atttggccgg gcgcggtggc tcatgcctgt     1140

aatcccagca ctttgggagg ccgaggcagg tggatcactt gagctcagga gtttgagacc     1200

agcctgggca atatcgtgag accccatctc tacaaaaata caaattaact gggcatcctg     1260

tcatgcgcct gtcatcccag ctacttgaga ggctgaagca gaagaatctc ttgagcccgg     1320

aaggcagagg ttgcagtgag ctgagatcgt gccactgcac tccagcctga gtgacaggag     1380

ttaagccctg tctcagaaaa aaaaaaaaca aaaacccaaa aagtacttaa agtttcattt     1440

acttagctag gagaaagact tggttctcaa aataatacat tttaagatta attgggtaga     1500

attagagttc cacctttatt cattgttgag cagtgattta tatttagtta ttatatttag     1560

gaatagaaaa tagaattaaa taatttaact tgattaatca accagaccaa ttttgacgtc     1620

tggagaactt ataaactcaa tatgttatat ttgttttcct gtatttaggt ggagaaatga     1680

gaaaaagctt tagttccaat tgacagttca ggtcaatgtt caatgaacat tcctatcttc     1740

taaaccagat ttctcttttt ttttcctgag acggagtctc gctctgtagc ctaggctaga     1800

atgtagtggc gtgatctcgg ctcactgcaa gctccgcctc ccgggttcat gccattctcc     1860

tgcctcagcc tcccgagtag ctgggactgc aggcaccgcc accacgcctg gctaattttt     1920

tgtattttta gtagagaagg tgtttcaccg tgttagccag gatggtcttg atctcctgac     1980

atcgtgatct gtctgcctcg gactcccaaa gtgctgggat tacaggtgtg agccaccgca     2040

cctggcctaa accagatttc tttagggcac aattttttct ggaatctcac tcttgttttt     2100

cacagtaatt ttaaaaacgt ttctactcca attaagaata tatatgatgt tattatatat     2160

gcttatgaaa cagatttatg agaaaagttt tttttaaata aattatttaa tcctagctct     2220

ttgttattca ccagcttttt aaaaaagtgt ttgaaaatta tacattctcg actttgggga     2280

ttagtttatt cttgtggcat cattataagg cttaattgtg gaaagctaag tacttgcttc     2340

tattccttcc aatgagagat tataacataa actattaaaa ttattctgct aatataccta     2400

gatttttatt tttaggtctc tgtccattgc ttttaattaa aattatctgt tttcaaatca     2460

a                                                                     2461


<210> 930
<211> 1964
<212> DNA
<213> Homo sapiens

<400> 930
cctctggagt ccctgtggca gaactcaaat ggaaggagga gcagctgcac ccaggggagc       60

agggtgtcac ctccgttgga tagagccggc caggttgcag cgcggacaca ctcgcaggtc      120

gctgtggccc cagcctcgcc tgacagaatg agcggctcgg acgggggact ggaggaggag      180

ccagagctca gcatcaccct cacgctgcgg atgctgatgc acgggaagga agtgggcagc      240

atcatcggga agaagggcga gactgtaaag cgaatccggg agcagagcag tgcccggatc      300

accatctccg agggctcctg ccctgaacgc atcaccacca tcaccgggtc tacagcagct      360

gtcttccatg cagtctccat gattgctttc aaactggatg aggacctttg tgctgctcct      420

gcaaatggtg gaaatgtctc caggcctcca gtgaccctgc gccttgtcat ccctgccagt      480

cagtgtggct cactgattgg gaaggctggc accaagatca aggagatccg agagactacg      540

ggtgcccagg tacaggtggc aggggacctg ctccccaact ccacagagcg agctgttacg      600

gtatctgggg tgcctgatgc catcatcctg tgtgtgcgcc agatctgcgc tgttatcctg      660

gagtccccac ccaaaggagc cactatcccc taccatccga gcctctccct aggtactgtt      720

cttctctctg ccaaccaggg cttctctgtc cagggtcagt atggggctgt gaccccagct      780

gaggtcacca agctccagca gctctcaagc catgcggtcc cctttgccac acccagcgtg      840

gtgccaggac tggatcccgg cacacagacc agctcacagg agttcttggt tcccaacgat      900

ttgattggct gtgtgatcgg gcgccagggc agcaagatca gcgagatccg gcagatgtca      960

ggggcacata tcaagatcgg gaaccaagca gagggcgctg gggagcggca tgtcaccatc     1020

actggctctc cggtctccat cgccctggcc cagtacctca tcactgcctg tctagagacg     1080

gccaagtcta cctctggggg gacgcccagc tcggcccccg cagacctgcc tgcccccttc     1140

tcgccacccc tgacggccct gcccacagct ccccctggcc tgctgggcac accctatgcc     1200

atctccctct ccaacttcat cggcctcaag cccatgccct tcttggcttt accacctgct     1260

tccccagggc cgccgccggg cttggcggcc tacactgcca agatggcagc agctaatggg     1320

agcaagaagg ctgagcggca gaaattctcc ccctactgag gccagctgag gtacaggcag     1380

gggcaggcag gaccaccagc agggggctgc ctctgcaccc tacccgccca aggagactcc     1440

accctggggt cccaaacgcc gctaacgccc agacgcatgg atgcaccccc taccctgcct     1500

ccatctatgg gagttctttc tctcagagtg ggggcagttt ctggcccagg ggtctgagct     1560

gcggcagccc cagggcaggg ggccctacct cctcagctct gtgcttggat acagggagca     1620

gccaggagac tccctagtgc ccccaccatg gcgggtgtca ctcacgcact ccccatccct     1680

tagggcttcc tggcctactg catccttgtg ggagtcaggg aggagggccc gttgggtagc     1740

tggggccagg cttctctccc caccacctgc agatttcttg ctgcttccac tgataccctt     1800

ttgactggaa tgaactggct gggcttgtca gggggcaccc caaagagggg gcactgccag     1860

gtagctgggg gagtggcatg gggcaggggc ccagttctca gcagcagaca ctctgtacag     1920

ttttttcaat ccctgttttt gaataaatat tctcagcgac cagg                      1964


<210> 931
<211> 716
<212> DNA
<213> Homo sapiens

<400> 931
tttccggtta gcgcggcgtg agaagccatg agcagcaaag tctctcgcga caccctgtac       60

gaggcggtgc gggaagtcct gcacgggaac cagcgcaagc gccgcaagtt cctggagacg      120

gtggagttgc agatcagctt gaagaactat gatccccaga aggacaagcg cttctcgggc      180

accgtcaggc ttaagtccac tccccgccct aagttctctg tgtgtgtcct gggggaccag      240

cagcactgtg acgaggctaa ggccgtggat atcccccaca tggacatcga ggcgctgaaa      300

aaactcaaca agaataaaaa actggtcaag aagctggcca agaagtatga tgcgtttttg      360

gcctcagagt ctctgatcaa gcagattcca cgaatcctcg gcccaggttt aaataaggca      420

ggaaagttcc cttccctgct cacacacaac gaaaacatgg tggccaaagt ggatgaggtg      480

aagtccacaa tcaagttcca aatgaagaag gtgttatgtc tggctgtagc tgttggtcac      540

gtgaagatga cagacgatga gcttgtgtat aacattcacc tggctgtcaa cttcttggtg      600

tcattgctca agaaaaactg gcagaatgtc cgggccttat atatcaagag caccatgggc      660

aagccccagc gcctatatta aggcacattt gaataaattc tattaccagt tccctc          716


<210> 932
<211> 6455
<212> DNA
<213> Homo sapiens

<400> 932
ccccccacgg tcccgcccct tcctaccttc cagtagccgg cggcggtgtc tcaggcggca       60

atggaaggat ccgagcctgt ggccgcccat cagggggaag aggcgtcctg ttcttcctgg      120

gggactggca gcacaaataa aaatttgccc attatgtcaa cagcatctgt ggaaatcgat      180

gatgcattgt atagtcgaca gaggtacgtt cttggagaca cagcaatgca gaagatggcc      240

aagtcccatg ttttcttaag tgggatgggt ggtcttggtt tggaaattgc aaagaatctt      300

gttcttgcag ggattaaggc agttacaatt catgatacag aaaaatgcca agcatgggat      360

ctaggaacca acttctttct cagtgaagat gatgttgtta ataagagaaa cagggctgaa      420

gctgtactta aacatattgc agaactaaat ccatacgttc atgtcacatc atcttctgtt      480

cctttcaatg agaccacaga tctctccttt ttagataaat accagtgtgt agtattgact      540

gagatgaaac ttccattgca gaagaagatc aatgactttt gccgttctca gtgccctcca      600

attaagttta tcagtgcaga tgtacatgga atttggtcaa ggttattttg tgatttcggt      660

gatgaatttg aagttttaga tacaacagga gaagaaccaa aagaaatttt catttcaaac      720

ataacgcaag caaatcctgg cattgttact tgccttgaaa atcatcctca caaactggag      780

acaggacaat tcctaacatt tcgagaaatt aatggaatga caggtttaaa tggatctata      840

caacaaataa cggtgatatc gccattttct tttagtattg gtgacaccac agaactggaa      900

ccatatttac atggaggcat agctgtccaa gttaagactc ctaaaacagt tttttttgaa      960

tcactggaga ggcagttaaa acatccaaag tgccttattg tggattttag caaccctgag     1020

gcacctttag agattcacac agctatgctt gccttggacc agtttcagga gaaatacagt     1080

cgcaagccaa atgttggatg ccaacaagat tcagaagaac tgttgaaact agcaacatct     1140

ataagtgaaa ccttggaaga gaagcctgat gtaaatgctg acattgtgca ttggctctct     1200

tggactgccc aaggcttttt atctccactt gctgcagcag taggaggtgt tgccagccaa     1260

gaagtattga aagctgtaac aggaaaattt tctcctttgt gccagtggtt atatcttgaa     1320

gcagcagata ttgttgaatc actaggcaaa cctgaatgtg aagaatttct cccacgagga     1380

gatagatatg atgccttaag agcttgcatt ggagacactt tgtgtcagaa actgcaaaat     1440

ttaaacatct tcttagtagg gtgtggagcc ataggctgtg aaatgttgaa aaattttgct     1500

ttacttggtg ttggcacaag caaagagaaa ggaatgatta cagttacaga tcctgacttg     1560

atagagaaat ccaacttaaa tagacagttc ctatttcgtc ctcatcacat acagaaacct     1620

aaaagctaca ctgctgctga tgctactctg aaaataaatt ctcaaataaa gatagatgca     1680

cacctgaaca aagtatgtcc aaccactgag accatttaca atgatgagtt ctatactaaa     1740

caagatgtaa ttattacagc attagataat gtggaagcca ggagatacgt agacagtcgt     1800

tgcttagcaa atctaaggcc tcttttagat tctggaacaa tgggcactaa gggacacact     1860

gaagttattg taccgcattt gactgagtct tacaatagtc atcgggatcc cccagaagag     1920

gaaataccat tttgtactct aaaatccttt ccagctgcta ttgaacatac catacagtgg     1980

gcaagagata agtttgaaag ttccttttcc cacaaacctt cattgtttaa caaattttgg     2040

caaacctatt catctgcaga agaagtctta cagaagatac agagtggaca cagtttagaa     2100

ggctgttttc aagttataaa gttacttagc agaagaccta gaaattggtc ccagtgtgta     2160

gaattagcaa gattaaagtt tgaaaaatat tttaaccata aggctcttca gcttcttcac     2220

tgtttccctc tggacatacg attaaaagat ggcagtttat tttggcagtc accaaagagg     2280

ccaccctctc caataaaatt tgatttaaat gagcctttgc acctcagttt ccttcagaat     2340

gctgcaaaac tatatgctac agtatattgt attccatttg cagaagagga cttatcagca     2400

gatgccctct tgaatattct ttcagaagta aagattcagg aattcaagcc ttccaataag     2460

gttgttcaaa cagatgaaac tgcaaggaaa ccagaccatg ttcctattag cagtgaagat     2520

gagaggaatg caattttcca actagaaaag gctattttat ctaatgaagc caccaaaagt     2580

gaccttcaga tggcagtgct ttcatttgaa aaagatgatg atcataatgg acacatagat     2640

ttcatcacag ctgcatcaaa tcttcgtgcc aaaatgtaca gcattgaacc agctgaccgt     2700

ttcaaaacaa agcgcatagc tggtaaaatt atacctgcta tagcaacaac cactgctaca     2760

gtttctggct tggttgcctt ggagatgatc aaagtaactg gtggctatcc atttgaagct     2820

tacaaaaatt gttttcttaa cttagccatt ccaattgtag tatttacaga gacaactgaa     2880

gtaaggaaaa ctaaaatcag aaatggaata tcatttacaa tttgggatcg atggaccgta     2940

catggaaaag aagatttcac cctcttggat ttcataaatg cagtcaaaga gaagtatgga     3000

attgagccaa caatggtggt acagggagtc aaaatgcttt atgttcctgt aatgcctggt     3060

catgcaaaaa gattgaagtt aacaatgcat aaacttgtaa aacctactac tgaaaagaaa     3120

tatgtggatc ttactgtgtc atttgctcca gacattgatg gagatgaaga tttgccggga     3180

cctccagtaa gatactactt cagtcatgac actgattaat acaagttgtc ttaacgttac     3240

tccaggacca cttgattttg gaaagagtgc acttaattca gaagctaaag aaaatcagtt     3300

cataatacta tggatttctc tttcattaag ccttaatttt aagggaaaca tcagtaagaa     3360

actgcactga agaattataa aacattttgg ggcatagcat acacttgtct aacggttcac     3420

acgtggctat gatcacaagc aactttgaac tggaatgcta tttacaaaag ttttgtgtat     3480

taatctgtgt attaatctct ctggataaaa agaaggaaaa aatatgtatg accagaacag     3540

atatggatga agaaattgaa agcaacgaat gcaactattc aaaaagttta attttatgaa     3600

tttctttttt gtttagtctt gaagactgat tttctatgca aatagtgttt ggcatcctgc     3660

acctctgata tgatttggct ttgagaattt aataccactg ggaagaagta tggtagtggt     3720

ggatgaaggg tggatatttt aaattgtgca gttacagttt actgtcctat tacctctgct     3780

cgtttaacca gtttgttata tcactgtgtc cccaaaatca ggatttttgt tgatagcatc     3840

agtgttgtag gagcaatagg tcagatgaga catattaact tagactaaac gtgaacagta     3900

ttatatggac tctcacaacg ctcttagaga atccgtgaat gtgaacagac aaatgtggct     3960

aaccatttga ttcttcagta tgccttctaa tgtggctatt ttatttatgt gagactctaa     4020

acctgattgt cctaatatat aaaactaaaa gattttgtaa agggagtgtc tttagaaata     4080

gatgaaatgt agaatgttaa aaattattgc tagggtagtc tttttttttt ccagaaacct     4140

aattagggta ttaaattttg tgtttttttt gttttttttt tttaaacaga agcatgttat     4200

ttcattccca ttcccagaaa gggagttaat gaagataaaa atttattttt taaggtcttt     4260

attgagagaa actttgtttt ctgatatgaa ctattgcaga tgtttttata aatactttca     4320

ttaaaatgat gtaaacagta gtacccaaca ctgtaaactc agtgaaaata gtaaatgatt     4380

cttttattac taagactgtc atgcattctg aagcagttgg ctttttttta accataggaa     4440

gtaatttccc tctagctcct ttccttctac tctcctgctc agaccattag taggtacttt     4500

gttaaataaa aaactagatt aacatcaata ttactccaat ttggtatctt ttacactatg     4560

tattatacct actttctttt tatttcattt acaaatagtt taaattactt tatcaaccag     4620

ctgtattgtt tccctcttgt aaaagtacca tcaagtgggg aaaatgtatg tggaagtgga     4680

gagtgaattt gtatgactaa aggataatct gtacatgggg aagtgggcaa aagtggatag     4740

gatgaattta aagaaaatga ctacctttgg aaaaaagaaa ttaaattttg ttcacatatc     4800

ctaccctttc ccattgtgca tatcccaagt gtcatattta aaactaaggt tacttaaaac     4860

agaatccagg aatatcaagg ctctgtggct tggaatttta gaggatagga ctaataaaag     4920

gacttttgca aagaaggctt ttttccacgt tcactttgtt ttgtgttctt tgaaagtaac     4980

tgatactttt cgggtagtta attcagcagt ccataaatat gatccagtaa cttgcttata     5040

ttttattgaa gtctcgacag ctcttcagaa gtaaatttag aacgatgctg tcagttcata     5100

tttatagata ttagtgtttt agcagataaa acaaaatcaa caaaaattaa gttcattttg     5160

tgattaaacc tgcaaccatt tttccattac tttttttcta tagttaatgg ttattgccat     5220

gatttcttct gtttggttct actaagctag aaagccaggg tgaagttaat gataattccc     5280

attattttat ttctgtacca tgagattgct gttgatgact gaaataccag gtgcaaaaat     5340

taatgatttg atttttgtac agtttcaatg agtatttttt acttattaaa aataaattaa     5400

gaaatgtaag aatatctttg taaatcatgt ttcataagtt gactccagag attctgattt     5460

tgctgtttat tttgtgagta atgttgcttt ggtgtttcct gattttcaag tttgcaatca     5520

tggagataca gcagttatta ggtgtggaag gacattacct caaatgtcct cagatggctc     5580

caggaaattc ttttaaaaca gttggagaga aatagtcgtg accatgtaaa acctagagga     5640

tctggtaaat cccatactac tggttaggga tttgtaaagt ccatttcttt ttagagttca     5700

aagcagttct gttacttgtc cataagttcc tcataaattg tcccaaaggt aggacatgga     5760

aataaatgta tatctttatt ttttaatcta ctatgtcaca ctctggtgat attcatggaa     5820

cattaaaaaa gcaactatgt ttattttata attagtaaaa tgaagataga aaattgttct     5880

tttgaaattt ttagggaaaa aaaaaatctc gtgacctaaa tctttccact ataatgaata     5940

ttcattgtga ttgcaaatat ctaattttat ataatcactg tgtatggatt tagcgatttt     6000

acttttcata gattcaaaaa catataatct gaatgctttc tctgaaaaaa aaaaaatcag     6060

agttgagctc ttgaggatca gagttaagta tccattgata atatgtgttc attttgctct     6120

atgtcataac tttgtttttt tattgagaaa tatatatttt tcaaaaacac atatatattc     6180

aaaaatacat aaaatataaa tatgcagttc aaggaataat tttaaagcaa ctatataact     6240

agcactcagc ttagtagaat atattgacag cagttcagaa attacacatg tagttccttc     6300

ccagtcacaa ccagctccct gccacgtacc ctttggtaat taccactatc ctaccttgta     6360

tgataattgt ctctttgttt ttatagtgtt accacctatg tgtgtaaact taaacaatac     6420

agtttgcttg tttttgagtt ttatttaaaa tcata                                6455


<210> 933
<211> 7732
<212> DNA
<213> Homo sapiens

<400> 933
ttcaaaccaa aacaaaaaga ttaaaggagc agcggccggg gcggcagcgg tccccaggcc       60

gggacacccg gggtggtgcg cccgggttcg cgggggctgc gccggcgccg gggaggcggg      120

gggagcggga gcgggcgacg cggggaaggg gggagccagg gggagggcgc cggccggagg      180

aggggcggac ccgcccgccc tagccgagca gagcacagcc gagccgagcg gcccgggcgg      240

gggccgaccc cggccagcgt cggcgcagag agcgggcgga ggcgcaggcc atgctgcggc      300

tggtgcccac cggggcccgg gccatcgtgg acatgtcgta cgcccgccac ttcctggact      360

tccagggctc cgccattccc caagccatgc agaagctggt ggtgacccgg ctgagcccca      420

acttccgcga ggccgtcacc ctgagccggg actgcccggt gccgctcccc ggggacggag      480

acctcctcgt ccggaaccga tttgttggtg ttaacgcatc tgacatcaac tattcagcag      540

gccgctatga cccctcagtt aagcctccct ttgacatagg tttcgaaggc attggggagg      600

tggtggccct aggcctctct gctagtgcca gatacacagt tggccaagct gtggcttaca      660

tggcacctgg ttcttttgct gagtacacag ttgtgcctgc cagcattgca actccagtgc      720

cctcagtgaa acccgagtat cttaccctgc tggtaagtgg caccaccgca tacatcagcc      780

tgaaagagct cggaggactg tcggaaggga aaaaagtttt ggtgacagca gcagctgggg      840

gaacgggcca gtttgccatg cagctttcaa agaaggcaaa gtgccatgta attggaacct      900

gctcttctga tgaaaagtct gcttttctga aatctcttgg ctgtgatcgt cctatcaact      960

ataaaactga acccgtaggt accgtcctta agcaggagta ccctgaaggt gtcgatgtgg     1020

tctatgaatc tgttggggga gccatgtttg acttggctgt agacgccctg gctacgaaag     1080

ggcgcttgat agtaataggg tttatctctg gctaccaaac tcctactggc ctttcgcctg     1140

tgaaagcagg aacattgcca gccaaactgc tcaagaaatc tgccagcgta cagggcttct     1200

tcctgaacca ttacctttct aagtatcaag cagccatgag ccacttgctc gagatgtgtg     1260

tgagcggaga cctggtttgt gaggtggacc ttggagatct gtctccagag ggcaggttta     1320

ctggcctgga gtccatattc cgtgctgtca attatatgta catgggaaaa aacactggaa     1380

aaattgtagt tgaattacct cactctgtca acagtaagct gtaaaaacag aacaatgaca     1440

taaatcaagg gagaaagaaa atgggcactt tatgtctcag aattactcaa atcaatttat     1500

ttttagttgg taatggatat aatatttctt aaaacaaaag taaggtgtta atgaataggt     1560

ctctccttct cctcctcctc ctcctcttcc cttgggggaa aaaaaaaaat gtgctaataa     1620

aacttccctc catggctaag agggaaaacg cttacattca attctttagt catggatggt     1680

ctcgttccag atgttattgt tccagggaac taaattcatt cctgatgcca gatctgatcg     1740

agtcagtatg tcttcagctt gatcagattt taaaatcagt tttgaaagtg gttcccgact     1800

tctttgcttt gggagaattt ggtcttatgc tcataagcag ttcatgagtg acaagtgtag     1860

caaaagccag ccatatattt tcagaatcta tatcctcagg aaatggtcct ttttttttct     1920

ataaatcacc aaccaactat ctaaatggac atttggggga attccctccc aaatttgatt     1980

ttgttattag aaaaatgatt ccgtgaacac agatgtgttt tgaagaagta gcacgtaatg     2040

gcttttatct accatcaacc tgataaggca catgtgaaat ggaaatgttc tctttcctct     2100

gaagcagcaa attaatgttg aaaacttaca tagacagaaa gtaggttttg gaaagggaaa     2160

ccacagagat tagggggact taaaattaat ataggcacag gaaagagaaa agtgtgcgct     2220

ccattctcag tgggggttca ccacaaaaca cgggccccag gagggaagcg ctgtctaggc     2280

acacggcaag gccttagtaa cagcatgcta cactgctcga ggtacggtat gtcccatcgc     2340

cctgtgcacc gtagagacct cagtcatctc aaggaagaat acatttgctt ctccttagag     2400

gcgttcgaac tagaagctat gcgttacctc tgattctgga aacagaatag cagccactca     2460

ttctgcattc ccatttttct ctccacgtgt tctggtggaa tgagatgctc cttggcacta     2520

tagcctgatg tcccacattg acccactgac cacacaggaa aagcagcgaa acctgcaccc     2580

tctcttctga gtcacgcctg tggctcatcg gcttccctct taacctttag tgccctgaag     2640

actgctgccg ctgtcaccgt tgcgctgaaa ccccatgggc ccgttctgat tgaaggtgaa     2700

gcccaccaga ttatttttca aagtcttagg tttcggtgta tctaacctgc tcagtaaata     2760

tggacgcaat taaagatgct ctaggaaatt tggggactgt atttaatttt tctttccttc     2820

catctgagga gcaaggaaat cctactgctg aatagctgtt agtatctatt ttacaagatt     2880

tactcatttt caggtaccta atgtagctgc tagcatgcat gcacaacaat acaatttata     2940

tggtaaatgg aaccaaataa tggcttcact gaatgttatg gctgcactga agggaaatgt     3000

cacggtaaat agctgccaaa ttatggatca tgccgaagtg tcacaactgc actaaagaca     3060

aatagcacta gaggctattg ccactgtgac gcttttgagt tatgaagaag ggtagcggcc     3120

tgatgcgagg ctctttgtgt cctcattata gcaaagggtt actggtgcag gggactagga     3180

aaaacccgtc cagtgtggtg cttagttatt catccatccc tttcagacct aacagccaca     3240

gccacacgga aagagacttt gcctcacttt tacattcaca aacaaacaaa ggagggggga     3300

gcaggtttta tgaatgtaac tgtgcacagg aaatgactgg taatggaaaa aatgttgtaa     3360

taaaataatc taatcaaaga atattattaa atttaacata gtctatgtcc aaaaggctta     3420

gttgcttctt atgcagatag atgtgtgaaa tctaagcagt aatgtacttt ctccctttgt     3480

aaagacttgg ggagtaagga cattaccaac taaattgctt cttcgaaact gaagtgagtc     3540

ccggtttgtt tcattttaat gggagggtaa taaagatgaa agaccaacat tttaactgat     3600

ggatccctta agctacagaa tagaaattta ttgtgttttg agggaatata ctaaatgcag     3660

ctatgtaaaa ataaaattca aacgcccagg attaaaataa aatataatct gaaaacctca     3720

tgttctctct ttccccaaac taagaaagtg cactgcatgc tgttttcact tattcttaga     3780

aaacaagcat gaaagattcc gcccattcag ataatgccaa aaatatgttt aaactttttt     3840

ttattctttt gaaaaatgat ttgtaaattg agggtcatag ttcagcatca gtttcatctt     3900

ctgggattat tgttcaagac cagcctctaa tgggaggtga aacggtacga tggtctcaac     3960

acctttcttc tgaactgtaa tacatatcac aaaaagtaca tccataattc agggcaattg     4020

tcagtctttt tagagaaggg gccagggtgg aacaatccca gtgagtaaat tatttctcag     4080

cgtggacttc tctgcatgtc gggcttaagg tcaccagccg ggcagggtgg aaggagcttg     4140

cctctttgag aaaccaagga gtcccagtga tctgttacca tttggttatg acttctaaag     4200

agccaaatgc tattccttca agcctgtttt gcaggcagaa aataccagca gtgtcattta     4260

ggggttcctt tgatgatgac tactgctgtt aactgacctc agcattaaaa aaaaaaaaat     4320

tcagggaata gtttgcaaag aaatgaagga agttttgcat gatatattct ataacttgtc     4380

attatatgat ttcatctgga tgaagttcct caggagtagg atagagcctc tgtaaatggt     4440

cattagtatt acattctgtg tttatctaat gaaagtgcag tgacaagtag ctgcttctta     4500

ttaaaatgaa aatcctgcat tatgtacttg aggaacattc cagctaatga ggatgtaatg     4560

tcctcagtac aacgcagacc ttctttttgt gttcaccacc acaagatgct ggaagcttga     4620

caaatgatat catttaagac acatgcctgc cttagggacc tggtttttgg cttcctgttt     4680

ctggctttta tttgggtaac gtttataatg gccacccgac ttgtacctgg gtaatgtttt     4740

aaccccttcc ccagagttct caattagcat gaatttacta cagtcagagt ttcctttaaa     4800

ttggggtggg ggtgctaagc actgaaaata tctttcttga ttactttacc atgtggacat     4860

atgggataaa tactgtattt cagatttaca taaaagtaga ttagtaatgc acagctttca     4920

gaataaaaac tgataaaaaa gaccaagcac tatcaacttt ggacagtaat ttcctaggtg     4980

ttaaacaagt tttctgaata caatctggat gcaaaacggc ctgatttgat gaattcataa     5040

ttttcttctg tatactttca ttttattaaa tattttatta cttggttaaa cacaagaatt     5100

atctatgtaa acttcatggg cttttttgtt gaaagttaga tgttcagtaa ctaatttccc     5160

agttatggcc cagaattaaa catttatgat catatttcag aagtcaaaat acaaaactgg     5220

attatcaaaa cggttggtgt ggtcacttta aactggacta tcagtatggt tgccgtggtc     5280

actttaagcg ggattatcag tacggttggt gtggtcactt tggtttatca tcaatacagt     5340

tggtgtggtc actttaaact ggattaccaa tatggttggt gtggtcgctt taaagtttgt     5400

tttcattttt tttctatttt taattcttac gggtatatag aaggtgtata tatttatggg     5460

gtacatgaga tgtcttgaaa caggcatgca atgtgaaata aataagcaca tcatggagaa     5520

tggggtgtct acctcctcaa gcatttatcc attgagttgc aaacaatcca gctacactca     5580

gttatttaaa aatgtacagt tattattgct tatagtcacc ctgtttgcta tcaaatagta     5640

ggtcttactc tatttttttc attttaaact ttgaatttta tttttcctag gcttatagca     5700

tcatgctatc ccccttgtaa aaggaggaat gcttggcatg agaaccttac tgctgttacc     5760

atgaacaaac tatggaatgt tggcaaaaga aaaaaaaaag ttacacaaaa cacacaaata     5820

acattttaat aatatgtatc agatcaagtg attcttagta gtagttgata ttcacaggaa     5880

gtcaaaaaag gacctatttc aattatgtct gcttgaatcc tgtttaattg tttccctggc     5940

tgagtagcta gtgtgacaca gcagcaagac taaaggggct ctgtggtcca cattgtcctc     6000

gagtctattc ttgcccatta tagacctgcc cattggtgct cactcactgc atcccaggag     6060

gcttgactgt cctcaggaag catgttgggg tgcccttaag ggtaagtatc ccggggagca     6120

cagtttggag aaaaccaata cgtcttcatg tatgttgaga agcgctgggc caaagtacag     6180

actttttttt tttttttttt tttttttggg acaagacctc ggctctgtca cccaggctgg     6240

agtgcagtgg tgcaatcatg gttgattgca acctcaacct ccctggttca agccatcctc     6300

ccacctcagt ctcctgagta gctgggacta caggtgcaca tcaccatgcc cggctaattt     6360

ttttgtattt ttttactaga gatgaggttc tactatgtag cccaggctgc tctggaactc     6420

ctgggctcaa gcaatcctcc cacctcggcc tcccaaagtg ctgggattgc aggcatgagc     6480

caccatactg gcctaagtgc agaaatttga acatgtgcct ccaccccaag ccaaaatttc     6540

ccttgaggag cactatctat ctgatgatgt ctttgaaacg gtatgaaatt aaaataatta     6600

aaacatcctg cacataggtg gtagcatcta atatgaaaga tggatttatg cttagagctc     6660

agaaaaatcc tcataaaatt attgtgtctt atcctcggca cctaaagaac tgaacagggt     6720

cttagaatga tcaaatggat ggtttgtttg gttggtggga gatgttgaaa cgtgggtaag     6780

gaatggtgtc cttagaagag aggttgccct agatgccgaa accctggagg tccatggttg     6840

ccagcagaaa cttacagctg ggaggagcct gcacccatct ctggctcttg tgaatgagaa     6900

gactcaattt gtgtttttgt ttttttgaga aagggtcttg ctctgtcacc cagactgaag     6960

tacagtagcg tgatctcagt tcactgcagc cttgacctcc tgggcccaag cgatcctccc     7020

acctcagcct cctgagtagt taagacttca ggtatgcatt accatgcctg gctaatgttt     7080

ttttattttt tgtagagaca aggtctccct cgttgcccag gctggtctca aactcttggg     7140

ctcaagtgac tttcctgcct cggccatcca aagtgctggg attacaggca taagccaccg     7200

caacatgccc cagttgcttt taaactgtta aatgtgggat ttaaagaata atctagttct     7260

acccatttta tgaatgaaga aaagaaactg ggacccagag agaaaaggtg cccggtccaa     7320

ggttacagag cccgttggac tcagaagtga agctggaaca ctggccaatg ccctcccatc     7380

cgccaggtga cttctctgca gtccccttta ccatctgccc gggtcctttg ggatacggct     7440

gactaggggt ttgaagaaca gcaattggcc tttgttatga atctttttgt ggagataaac     7500

ccagtagaag tatcacggtt ctgaccatga aagtgtgttc aactctaatc cagcacaatt     7560

aggattccag atcatttgat tctgtgtcgt ctaaatatca cagaaagtta aaaacaaatt     7620

agcctcaatg gaattaatgg cttaatatcc ataatttagt tttaatgcta ggaggaaggg     7680

ctcctgtgaa tgtgttctta caaatcaaat aaagaaaatc aaatagagaa aa             7732


<210> 934
<211> 3528
<212> DNA
<213> Homo sapiens

<400> 934
agcgtgcgcc gctggccagg tgcgcaatag tggggtatgc gtcacggtct gcgccgcccg       60

cggggccagg acggggcgga gcttccgcct gggctggggt tggcgagttc acccgcggcg      120

gagggtaact ttgctgtgct gttttttgag cagttgtctg gtccctggaa gtgtagcatc      180

gagagagttt tctaattacg tttacaaaat atcttccctt tggccataca agtggtgact      240

gccatgtcga actcgcggcc caggtcccgc cgagacgccg ggggtggcgc tggggcagcc      300

ggccgggacg agctggtgtc gcggtccttg cagagcgcag agcactgtct gggcgtccag      360

gacttcggca ctgcctatgc ccactacctc ctcgtgctca gcctggcgcc ggagctgaaa      420

cacgacgtga aggaaacttt tcagtacaca cttttcagat gggctgaaga gcttgatgct      480

ctcagtcgga tacaagactt acttggttgc tatgagcagg ccttggaact gtttcctgat      540

gatgaagtga tttgcaatag tatgggggag catctcttca gaatgggctt tagggatgaa      600

gcagctgggt attttcataa agcagtgaag ctaaaccctg atttcagtga tgcaaaggag      660

aatttttatc gtgttgcaaa ctggttggtg gaacgctggc actttatcat gcttaatgac      720

accaagagga atacaattta taatgcagca atccaaaagg cagtttgttt ggggtccaaa      780

agtgttttgg acattggagc aggaactgga atactaagca tgtttgctaa aaaagctgga      840

gcacattccg tgtatgcctg tgagttatcc aagaccatgt atgaacttgc ctgtgatgtc      900

gtggcagcaa acaagatgga agcagggatc aaactcttac atacgaagtc acttgacata      960

gagattccaa aacatattcc cgaaagagtg tccctagttg taacagaaac tgtcgatgca     1020

ggtttatttg gagaaggaat tgtggagagt ttgattcatg catgggagca tttactttta     1080

cagccaaaga ccaaaggtga aagtgctaat tgtgaaaagt atgggaaagt tataccagca     1140

agtgctgtta tatttgggat ggcagtagaa tgtgcagaga taagaagaca tcatagagtg     1200

ggtattaagg acattgctgg tatccatttg ccaacaaatg tgaaatttca gagtccggct     1260

tattcttctg tagatactga agaaacaatt gaaccttata caactgaaaa gatgagtcga     1320

gttcctggag gatatttggc tttgacagag tgctttgaaa ttatgacagt agatttcaac     1380

aaccttcagg aattaaaaag tcttgcaact aaaaagcctg ataagattgg tattcctgtt     1440

attaaagaag gcatactaga tgctattatg gtttggtttg tgctccagct tgatgatgaa     1500

catagtttat ccacaagtcc tagtgaggaa acatgttggg aacaggctgt ctaccccgta     1560

caggaccttg cagactactg gataaagcct ggagaccatg tgatgatgga agtatcttgt     1620

caagactgtt acttaagaat ccagagtatt agtgtcttgg gtttggaatg tgaaatggat     1680

gttgcaaaaa gttttaccca gaataaagac ttgttatcgt taggaaatga ggctgaactt     1740

tgtagtgccc tcgctaacct tcagaccagt aaaccagatg ctgtagagca gacatgtata     1800

ttggaatcta cagaaattgc tttgcttaac aacatcccat atcatgaagg ctttaaaatg     1860

gcaatgagca aagttttgtc ttcactgact ccagagaaac tgtatcagac catggatact     1920

cactgtcaga atgagatgag ctctggaact ggacagagta atactgtaca gaacatcctt     1980

gaacctttct acgtgttaga tgtgtccgaa ggcttctctg ttctgcctgt tattgctggc     2040

acacttgggc aggttaaacc atacagttct gtggagaaag accagcatcg tattgctctg     2100

gacctcatat ctgaagccaa tcactttcct aaagaaacac ttgagttttg gctgagacat     2160

gtggaggatg aatctgctat gttacaaagg ccaaaatcag acaagttatg gagcataatt     2220

atattggatg tcattgagcc atctgggctc attcagcagg aaataatgga aaaagctgca     2280

atatccaggt gtttactaca atctggaggc aagatctttc ctcagtatgt gctgatgttt     2340

gggttgcttg tggaatcaca gacactccta gaggagaatg ctgttcaagg aacagaacgt     2400

actcttggat taaatatagc accttttatt aaccagtttc aggtacctat acgtgtattt     2460

ttggacctat cctcattgcc ctgtatacct ttaagcaagc cagtggaact cttaagacta     2520

gatttaatga ctccgtattt gaacacctct aacagagaag taaaggtata cgtttgtaaa     2580

tctggaagac tgactgctat tccattttgg tatcatatgt accttgatga agagattagg     2640

ttggatactt caagtgaagc ctcccactgg aaacaagctg cagttgtttt agataatccc     2700

atccaggttg aaatgggaga ggaacttgta ctcagcattc agcatcacaa aagcaatgtc     2760

agcatcacag taaagcaatg aagagcagtt ttccaatgaa aactgtgtaa atagagcatc     2820

aacaagtaca aaattcttgt cttaattagt gggggtatat aaaaattcct tgtaatggtc     2880

aaatattttt taaaattgac attaataaag catattttaa aagattctaa ataaaagggt     2940

agcattatta tagaaatact gctgcagatt tgctttctgg aaaaggatac atcactagtt     3000

ttttaaatta ggaaacttct tttgctcgat tttacagaat agggatttta aaagtcttat     3060

cgttattgac atgtgtaagt aaagcaaaac tttacttttg taggcatctt ggcctttttt     3120

cttaaatcca aacttgtaat tgggaaacac tgaaaggctt ccactgaaga ctgagggtta     3180

tggttacctg taaattccaa tcttgcttcc tttaaatact cagtgtacat ctgaaacatc     3240

tcaggttttg ttttgagaat gcaagcttga aaaagaattt aagctataag ctaaatgtaa     3300

ttaaaacagt aaaggagtta gggaatacat cttcaggagg cagcattttt cttggtctac     3360

tttggcaaaa gaacatttaa aagctggtaa caaaacaaag ttaaattgaa ggaagactta     3420

atcctatact atttttcaaa gttttgattt ggatgtacaa taagtacatt aattgatcca     3480

atttttacaa acttttgaaa taaaggaaga tcattattat gcctccta                  3528


<210> 935
<211> 2142
<212> DNA
<213> Homo sapiens

<400> 935
gctttccttt tagcttttgt aagttacacg tcaaaatggc cgatctgaca tcggtgctca       60

cttctgttat gttttctccc tctagtaaaa tgtttatcgg tggactgagc tggcagacct      120

caccagatag ccttagagac tattttagca aatttggaga aattagagaa tgtatggtca      180

tgagagatcc cactacgaaa cgctccagag gcttcggttt cgtcacgttc gcagacccag      240

caagtgtaga taaagtatta ggtcagcccc accatgagtt agattccaag acgattgacc      300

ccaaagttgc atttcctcgt cgagcgcaac ccaagatggt cacaagaaca aagaaaatat      360

ttgtaggcgg gttatctgcg aacacagtag tggaagatgt aaagcaatat ttcgagcagt      420

ttggcaaggt ggaagatgca atgctgatgt ttgataaaac taccaacagg cacagagggt      480

ttggctttgt cacttttgag aatgaagatg ttgtggagaa agtctgtgag attcatttcc      540

atgaaatcaa taataaaatg gtagaatgta agaaagctca gccgaaagaa gtcatgttcc      600

cacctgggac aagaggccgg gcccggggac tgccttacac catggacgcg ttcatgcttg      660

gcatggggat gctgggatat cccaacttcg tggcgaccta tggccgtggc taccccggat      720

ttgctccaag ctatggctat cagttcccag actatttgcc ggtttcacaa gacataattt      780

ttatcaacta gctcttaaga gaggcatagc aaagtggggg ttgctaccat ttctagagag      840

agaggacaca gtcccggcct gggctgcccc cgctccagtc aatgctcact gaaagtctgt      900

cttagctgcc tgtttgaatg actgttcttt ttctcatttt taattcttgg actcatgtcc      960

tcattgcttc actcaattaa aaaaaaatta ttctccagtc ccctcccact ttgcttcttg     1020

tatgcattgt gaccgacccc acttcctcag aatgtaacgg ggccagaggg aaacttctca     1080

caaacttcgt agagcctcct caggggaagc taggaagaag acatcaaatg tttttaagtc     1140

atgaccaaac aggcttgttg gggacatatc atggggtgag ctttgaagtg ctggtggtcc     1200

agaggggttg cagatacgtg acttggagca cccgtgtctt acgatggaca gtgataaagg     1260

tgaacacaca gagacagact attctctaag aatgtgagaa acctgatctg gaagaggagc     1320

tatataaaca ctatctgact atctttgtct tttggggcca gtggctgttg gcataatcac     1380

aagcctgtct gtcttcgaga agggacagtg gagtcatcca ggtgctgcca catgacaggc     1440

acggtgggca ccgatccaca gtgggccccg ccttccccag ctcgcctccc tgcctgtgct     1500

ggcctggcct tgcctgctgg caccattgga gtaggagggg gtggaacaca gggggcccat     1560

cctgatcagg ccccatctca aggttggcac tcctgcccat cacccttaga aggatctttt     1620

cccatggctt gacttccttc atttccctaa ctgaaataca cccactctct tggaataatg     1680

acgtaccact cagttggacc ctcaagagtc actgctttgt ctgtgctggt agtttgtgag     1740

aagtgacccg cacgcttcca tttgatgcat ttgatgtgag tgaatccata catttgaatg     1800

tcattgtcct tgagacccta catgtgcagt ttggctcatc tcattaaaga tgcttgatgt     1860

aataattggt tagtttcctt ttattttcct gcaggctttt ccatgagtat tatttttttc     1920

aaagaacaaa tctgtatggc ttttccccat ctccatattt tgttttgcta tgaattgctt     1980

tgctttggtg aacttgtcct agtatgcttg cctcacaaac gttttagcca ttgtgaattt     2040

tcttcatctc tgtaaatagt tcatctgtgc ttctccctga tgacgtttta ttttttttcc     2100

cctgtaagca accgaggtag aaaaataaat tgtttaccat gg                        2142


<210> 936
<211> 668
<212> DNA
<213> Homo sapiens

<400> 936
tgccccatgc tgactccttg cttctttcca gccggagccg ctgccttgcc ccccggagac       60

tgaagacatg gcacccaaga gggccaagag aaggacagta gagggcggaa gctccagcgt      120

cttctccatg ttcgaccaga ctcagatcca ggagttcaaa gaggccttca ctgtgatcga      180

ccagaaccgt gatggtatta tagacaagga ggaccttcgg gacaccttcg cagccatggg      240

ccgcctcaat gtgaagaatg aggagttgga tgccatgatg aaggaagcca gcggtcccat      300

caacttcacc gtcttcctga ccatgttcgg ggagaagctc aagggtgccg accctgagga      360

tgtgatcacc ggagccttca aggtcttgga ccctgaggga aagggcacca tcaagaagaa      420

gttcctggag gagctgctga ccacgcagtg tgaccgcttc tcccaggagg agatcaagaa      480

catgtgggcg gccttccccc ccgacgtggg cggcaacgtc gactacaaaa acatctgcta      540

cgtcatcacg cacggcgacg ccaaggacca ggagtagggg cacccgcggg cctccgctgc      600

ccgacgcttc tgttcggccc gacctccacc ccggctccca ataaaattta actgatcttt      660

gtttctta                                                               668


<210> 937
<211> 2121
<212> DNA
<213> Homo sapiens

<400> 937
cttacggcgg ccggccttct ttgtaggcct ggcaccgtag aggtagagga gctacattgg       60

ccgcgtcccc tgtccctctg ccctcttgcc catctgccca aacttttgta tttgatctct      120

gttttgatgt cgaaccccaa agcactgtaa ttgggggggg cggggggggg ggtggaacct      180

gcggacctga gagcagcgcg cgtgcgcacg acacgcgctg tgcgccggaa gagcacgccc      240

agtccgggct gcgcggagga agcgctgggg tcccggaggg cgggggtggc ggcgccggag      300

gtcgccatgg ctaccgagcc cgaagccgcg gagccggtgg tgccttcgct cgtggatcga      360

tacttcactc gctggtacaa accggatgtc aaaggaaaat tttgtgagga ccactgtata      420

ctacagcact ctaaccgaat atgtgtcatc acattggcag aatctcatcc agttcttcaa      480

agtggaaaaa caattaaaag catttcctat cagatcagta ccaactgtag cagacttcag      540

aacaaggtct ctgggaaatt taagcggggg gcacagtttc taacagagct tgcacctctc      600

tgtaagattt actgctcaga tggtgaagaa tatactgtgt ctagttgtgt tagaggacgt      660

ttgatggaag tgaatgaaaa catcctccat aagccatcta ttcttcaaga aaagccatct      720

actgaaggct acattgcagt tgtgttaccc aaatttgaag aaagtaaaag cataacagaa      780

gggttactga cacaaaaaca atatgaagaa gtcatggtga aacgcattaa tgccacaaca      840

gctacgtcat gaggattgac atggaacaaa aagcaaagtg ggattcttgt tacctggcct      900

aaaccatcag ggtactaaag gagaagaacc agtatatgta aagcatacct aacagccagc      960

catatgcagg ggaggcctag tgcttcactt agttttccct ctctgtcttc ataatgagcc     1020

ttggttccca tttgtctaca gcctgccaga tctggcctgc ccatgtactc acactgttct     1080

cttgcatctc tctaacaact ggcatgcaag gcatgttttt ctgattaaaa acaaacaaag     1140

ctctttgaag aagatttaga aaatacagaa gagttttaag tagccaagta aaaataattt     1200

acccatcatc ccataatcca gaagtaaata catttgaccc ttgagcaaca taggtttgaa     1260

ctgcaagggt ccacttatgc atggactatt ttcaactata aacgagtcaa aaatatatca     1320

ttaaccaaac acgaaaccca cttatagagc aggttcatat actcaggttc caaagggcca     1380

actgcaggac ttgagttctc acgtatggat ttgggtatat gtggaagttc ctggaaccaa     1440

tcccctatgt aaaccaaggg ataactacta cattttaacc tacttctgtt tgaacatatg     1500

gtatggttat tgcttttgcc tcgttttcct aacagtttga agtttaaaaa aacctaaccc     1560

acctttctta cccagtcttc tataatgtgc ctaccaaaaa gcctagtcct agcccatctg     1620

cctcaactcc tctccctttt aggttgtagg gaagaggccg gagtgtagag tatattatat     1680

cttctgtccc ccttatgcca acaagatggc cttcccctct gaaacaaagt aaaactgcaa     1740

cactgtgact tcttaaatga gggatatgtg aaaaggctat gaaaaataca aaggctttcc     1800

taggaaatgt gttataatgc agcgggaagc taattcttga aatatgcaca ttatagttac     1860

tcagtctcac atactctagt tactggcaaa gaagttactg agaatatgtc attcaaaggc     1920

ataggggcct ttgaatggaa caaatgcttt cacatcattt aaagtaaaaa aaaacctcca     1980

acaactgtga atttatagtt taagagtgat ttacactgaa tttcaaataa aaggactata     2040

aaacgtgtta tttttctgta agggctataa catacatgtc aatatcactg tttttaaata     2100

aaatatactt ttatacagaa g                                               2121


<210> 938
<211> 2382
<212> DNA
<213> Homo sapiens

<400> 938
cccggcaccg cggcgctcgg gtgtttttgg gggcccgggt ggagggcccg ggtgccgggg       60

cccaaggtgc ggcctcgcta gcgggagagg gagcgggatc accggcccgg agagagctct      120

cagggccaga gcggggcagg aggatgcttt cccagcccca ccatggagct gcgctgtggg      180

ggattgctgt tcagttctcg ctttgattca gggaatctag cccacgtgga gaaggtggaa      240

tctttgtcca gtgatgggga aggggtagga ggtggggcgt cagccctgac cagtggcatt      300

gcctcttccc ctgactatga attcaacgtg tggacccgac cagactgtgc tgaaacggaa      360

tttgagaatg ggaacaggtc atggttctac ttcagcgtcc ggggaggaat gccaggaaaa      420

ctcatcaaga tcaacattat gaacatgaac aagcagagca agctgtattc ccagggcatg      480

gccccctttg tgcgcacact gcccacccgg ccacgctggg aacgcattcg agaccggccc      540

acctttgaga tgacagagac gcagtttgtg ttatcctttg ttcatcgttt cgtggagggc      600

cgtggggcca ccaccttctt cgccttctgc taccccttct cctacagtga ctgccaggaa      660

ctgctaaacc agctagacca gcgctttccg gagaaccacc ctacccatag cagccccctg      720

gataccatct attaccatcg ggagctcctt tgctattctc tggatggact tcgtgtagat      780

ctgctgacga tcacttcctg ccatgggctt cgagaagatc gagagccccg tctagagcag      840

ctatttcctg ataccagcac ccctcgacca ttccgtttcg caggcaagag gatattcttc      900

ttaagcagta gagtacaccc aggggagact ccatctagct ttgtcttcaa tggctttctg      960

gacttcatcc tccgacctga tgatccccgg gcccaaaccc tccgtcgcct cttcgtcttt     1020

aagctgattc ccatgttgaa ccccgatggt gtggtccggg gacactaccg cacagactca     1080

cgtggagtga atctgaaccg tcagtacctg aagcctgatg ccgtcctgca cccggccatc     1140

tatggggcca aagctgtgct tctctaccac catgtgcact ctcgtctgaa ctcccagagt     1200

tcctctgagc accagcccag ttcctgtctc cctcctgatg ctcctgtttc tgacctggag     1260

aaagccaaca atctccaaaa tgaagctcag tgtgggcact cagctgacag gcataacgct     1320

gaagcctgga aacaaacaga gccagcagaa cagaagctca acagtgtgtg gattatgcca     1380

caacagtctg cggggcttga agagtcagcc cctgatacca tcccccccaa agagagtggc     1440

gttgcttact atgtggacct gcatggacat gcttccaaaa ggggctgctt catgtacgga     1500

aacagcttta gtgatgagag cacccaggtg gaaaacatgc tatatccaaa gctcatctcc     1560

ttgaattcag cccacttcga cttccagggc tgcaatttct cagagaagaa tatgtatgcc     1620

cgagaccgta gagatggcca gtctaaagag ggaagcggcc gtgttgcaat ctacaaagcc     1680

tcagggataa tccacagcta cacacttgaa tgcaactaca acactggacg ctcagtaaac     1740

agcatccctg ctgcctgcca tgacaatggg cgtgccagcc cccctccccc gccggctttc     1800

ccctccagat acactgtgga actatttgag caggtgggac gagctatggc cattgcagcc     1860

ctggacatgg cggaatgtaa tccgtggccc cgaattgtac tgtcagagca cagcagcctt     1920

actaatctac gggcctggat gctgaaacat gtacgcaaca gccgaggcct aagcagcact     1980

ctgaatgtgg gtgtcaacaa gaagaggggc cttcgaactc cacccaaaag tcacaatggg     2040

ttgcctgtct cctgctccga aaacaccttg agtcgggcac gaagttttag caccggcaca     2100

agtgccggtg gtagcagcag cagccaacaa aattctccac agatgaagaa ttcccccagc     2160

tttccttttc atggcagtcg gcctgcaggg ctgccaggcc tgggctctag tacccaaaag     2220

gtcacccacc gggtgctggg ccccgtcaga ggtaagccag tctgggagcc cctgcaacat     2280

gtgttcggtt gtctggggca ttgctggggg aagtaagagc ttgaagatat actgttggcc     2340

caggaccaag gggtgaatca ataaaattag tttgtagcag aa                        2382


<210> 939
<211> 3986
<212> DNA
<213> Homo sapiens

<400> 939
aaagaggctc gtggcgcccg ccttccggtg cctcagtccc tgccagtagc cacccgacgc       60

cgtccggctg ttcctcgttc gccctctccc tccgcctagc ccgcttctac ccggacggct      120

cccggcgcag gctgcagctg ttccgtcagc tgccgctcct cctcccagac gcagagcgcc      180

gctctgcccc gccccccgcg caggctgccg tccctacatc cgggtaccga ctccagccgc      240

ctagacgctg gcactatggt catggcggag gggacggcag tgctgaggcg gaacaggccg      300

ggcaccaagg cgcaggattt ctataattgg cctgatgaat cctttgatga aatggacagt      360

acactagctg ttcaacagta tattcaacag aacataagag cagattgctc caatattgac      420

aaaattcttg aaccacctga aggccaagat gaaggtgtgt ggaagtatga acatttaagg      480

cagttctgcc ttgagctaaa tggacttgct gtcaaacttc agagtgaatg ccatccagat      540

acttgcactc aaatgacagc aactgaacaa tggatttttc tttgtgcagc tcataaaact      600

ccaaaagagt gtcctgctat agactatact agacacacac ttgatggtgc tgcatgtctt      660

ctgaatagca ataaatattt tcccagcagg gttagcataa aggaatcatc tgtagcgaaa      720

ctaggatcag tatgccgtag gatttacaga atattttcac atgcttattt tcatcatcgg      780

cagatatttg atgaatatga aaatgaaaca tttttgtgtc atcggtttac taagtttgtg      840

atgaaataca atttgatgtc caaggataac ctgattgtac caattttaga agaggaagta      900

cagaattcag tttctgggga aagtgaagca tgaagggaat cataggaaaa atgtactgat      960

catataatta acattatgta ctgtatatat cattttagac acatcaatca tgtatccata     1020

ttatagcttc tttgtttagt ataggttttt gtatgctggg tttgcctttt aaaatgggaa     1080

atacttttta agttattcat aagctgtata ttcaccagtg tggcactcat ggtttttaaa     1140

taagattagt attatctgtt tataatgcct gttaataaaa gaatttacag tttggtaaaa     1200

ttgctgctaa acaatcattg gatcacaatc ctcatcagac aaacccatct gtaaaaaaaa     1260

tgagggagag cttgaggttt cacacaagcc atttactaaa gaggtagaaa tgttttctat     1320

tggttttacc ttgagtttag atatcctaaa aaattctgta gtacgtagtt ttgtcttacc     1380

tgttaacttt ccccaattga gataaaagtg ttttaaaatt ctgtttatag tttttgatat     1440

gcatatataa ttatgtgtat atctaaatac aaatgcaaat gaagcattag taatacttaa     1500

ataattttac tgtgctacat aaagtataac atacttggaa aggatttacc gttctgcaac     1560

aacggactgg tacatacagg atgatcacaa tggtaaggca cataaattat tttcccactg     1620

gaaacctgcc ctgtccaccc cttctcattt cccttaacct tatcttcaaa ctactttagc     1680

tgagaagctt ttcaccagac tgagttagtg gtggcttata cctatttata tttgtattaa     1740

ttgcttacag attatacctc atattagcaa ttacattaca ctacaagaaa atgtatttgc     1800

ataggctctt gcttatcttt gttttgcaaa attgttctac ttagaaaaca gtccttaaaa     1860

tagtttgact cttcctgtta gtaatatatt aatctttcat ttaaccagct aggcagcatt     1920

aaatagaatt gaagaaatac catagtattt attttacacc ccctctccca cgaagtttat     1980

gtttggatta catgcacgtg tgagattatt tgcaataatt cataggttcc aagggtgttg     2040

atgaatagtc atacattttt ttggactttg ttataattca ttgtggtaag aatgattgaa     2100

atgcagattt aacaatctta taatctattg aatgccattt ttgataaagc actggaggtc     2160

ttattgccaa actgattgta atgaggcagt aagggtgaaa acattgtaca tgttgtgaag     2220

aaagtattta aatccaactt ttgaacagat ttaacaaaca tgaggaactt ttttatttag     2280

aaggataatt ttgaagatga aaatgtattc atcttaattg ttttttcaaa tttaagggaa     2340

taatttatac catcttttca gacaagaatg tacagcaaaa ataaggggaa cagtagtata     2400

ctgagagtgt gtgtatgtat agtgtatgcc tttccaagct tgccagtctt tttggctttg     2460

aacactgccc atcagctaca gtcattactg ttccccaacc cacaactatc ttttaagaag     2520

tcttagttca cagtgaaagg aatgatgact ttgaaattat ggatttatat taatggcact     2580

ataaaccaat ggtaatggta atttttaaac ttgctaaata ttgagaaact aaactactaa     2640

gttaataaat tatatatagc agtgtagctg ttctctctag atggtgtctc acaatggatt     2700

tctgttgctt gactattttc ttagtgaata tttatactaa ggtagtgact gagatttggt     2760

gatctggctg agtattttga aacacatttt gaataatatg gcttagtgtt aacggggact     2820

taaatatgat ttttttttct tactcatttc accttccctg tactgtatgt ttggaattga     2880

tcataaaaca tctccaaaag aaaataatca gtttgtagtc ttgcttttgt attcatgttg     2940

ataatcttac taattgtgaa gttgattcac tactatacta ggtaagacct aagtgaaaca     3000

gttcctgttt ttccttaata ctgttttcag aattttgaaa atgtacttat atatacataa     3060

atactactaa aaaattaatg agcctggcaa accattgatt tataaaagta agtgttctaa     3120

gaggggaaca agacagttct gtgtgataag gaagttaggc tccacttttt gtttgaatta     3180

ccctatgtat atccgaaggt aaacttaggc ttttctttcc aaaagatcgt atagtcaatt     3240

cattcttttt ctcctatcac atctgggaaa gtagctaact tttaactatt tatgttccca     3300

taagtaaccc ttcttttgtg tgtatacatt tccttttctc tgacttgaga tgtcaaattt     3360

ggatttctag aacagtttct cagttaaatt cttgatgact taacaacttt tactatcaga     3420

atacaattag aaatccttgg tcaggcacag gggctcacgc ctgtaatccc agcactttgg     3480

gaagccaagg cagacagatc acctgaggtc aggagttcga gaccagcctg accaacatgg     3540

agaaaccctg tctctactaa aaatacaaaa attagccggg cgtggtgcta ctcgtgaggc     3600

tgaggcagga gaatcgcttg aacccgggag gtggaggttg cggtgagctg agatcgtgcc     3660

attgcactcc agcctgggta acgagcaaaa ctccgtctca aaaactccgt ctcaaaaaaa     3720

aaaaatcctt gattacattg ttagtaagga ctgtgttacg attataaaca catttattgg     3780

ttgatgtcaa attcactgta atagtagaac taagtttttt atgtgagtac tttgccctac     3840

tgtctatatg atgacatctt ttttgagcag ctaaatttta aattgtatat actttatttt     3900

gtgaatcctt gttgaatgtg ctaaaggttt ctttgtgtag ttcttccatg ctatgcgaat     3960

attttagtaa aagtagttga ttttta                                          3986


<210> 940
<211> 2410
<212> DNA
<213> Homo sapiens

<400> 940
gagacaggaa ggtggcaaag gaaggagccc atttgcatga caataattga gccaagaata       60

gaaagccaca gggatgcaag ggtgaggctg gcggctgagc tgggctaaac ctcacaaatc      120

agactaccca gctctgctcc gcaggggaag ggagactgag ccctgggcca ggcttggcag      180

agagggaagc gggaggacac gaccccaggg cattgtggga acactggcca ggctggactt      240

tgccttcctc ctcgtccttt agccgggagc ctgtctttgc ttgcctttgc ctttgaggct      300

ctgtggctgt ggggctgagt ggcatcatgg cggctcagaa agatctctgg gacgccattg      360

tgattggggc ggggatccag ggctgcttca ctgcatacca cctggccaaa cacaggaaga      420

ggatcctcct gctggagcag ttctttctac cacactcccg aggaagctcc catggacaaa      480

gccggataat ccgaaaggcg tacctggaag acttttacac ccggatgatg catgagtgct      540

atcagatatg ggcccagctg gagcacgagg ctggaaccca attgcacagg cagactggat      600

tactgctgct gggaatgaaa gagaatcaag aattaaagac aatccaggcc aatctgtcga      660

ggcagagggt agaacaccag tgtctttcat ctgaggaact gaagcaacgt ttcccaaata      720

ttcggttgcc caggggagaa gtggggctct tggacaattc cggaggagtt atctatgcat      780

ataaggccct cagagccctg caggatgcaa ttcgacagct aggaggcata gtgcgtgacg      840

gagagaaggt ggtggagata aacccagggc tactggtcac ggtgaaaacc acctccagga      900

gctaccaagc taagagcttg gtcatcacag caggtccttg gaccaaccag ctcctccgtc      960

ccctgggcat tgagatgcct ctccagaccc tgcggatcaa cgtgtgttac tggcgagaga     1020

tggttcctgg gagctatggt gtgtcccagg cctttccgtg cttcctgtgg ctgggcttgt     1080

gtccccacca catctacgga ctgcccacag gagagtaccc agggctgatg aaggtcagct     1140

atcaccacgg caaccacgca gaccctgagg agcgggactg ccccacagca cgcacagaca     1200

tcggagacgt ccagatcctg agcagctttg tcagagatca cttacctgat ctgaagcccg     1260

agcctgctgt cattgagagc tgcatgtaca cgaatacccc tgatgagcag ttcattctcg     1320

atcgccaccc aaagtatgac aacattgtca ttggtgctgg attctctggg cacgggttca     1380

agctggcccc tgtggtgggg aagatcctgt atgaattaag catgaaatta acaccatctt     1440

atgacttggc accttttcga atcagccgtt tcccaagcct gggcaaagcc cacctttgac     1500

ctctggccag aagcctccct tctgtgcaca ggagccagtt tcacagatgg agaagatgtc     1560

tcagatgaag ggagtgtccc tgagatatca tccttttctt ctgcctcgcc tgaatccccc     1620

ataaacacca gatgattgag tctaccttct ttccttggcc cgctcccttt ttcttctgcc     1680

tcacttgaat cccccgtaaa caccagacga ttgagtctac cttcttttct tggccacctc     1740

cccattcaca actactttct cgctcccaga aggttgatca gatattctac aatcacagag     1800

tagcaaggac gtttgagatg ggtatatcag taagaagagg gcacaagaac tggctctgga     1860

gaccaaagca gttgttaaaa attctctttg ctgggggccg ggtgtggtgg ctcacacctg     1920

taatctcggc actttggggg gctgagacag gcggatcacc tgaggccagg aattcaagac     1980

cagcctggcc aacatggtga aaccctatct ccactaaaaa tacaaaatta gctgggtgtg     2040

gtggcgcatg cctgtaatcc cagctacttg ggagactgag gcaagagaat cacttgaacc     2100

cgggaggtgg aggtggcagt gagccgagat tgcgccattg cactccagcc tgggcaaaaa     2160

gagtgagact ctgtctcaaa aaaaaaacaa aacaaaaaaa acctctttgc tggtatattt     2220

gaagagcttg ggatggattt gactaaatct gccccgagga gggtgaacaa ggtgatctca     2280

gagatcacta ctgctcttgg agttccttct cctaaagcta aggccagcct ccatcacaaa     2340

tgcccataaa atctggctcg tctttgatga acaataaata tttgttgaac aaataaataa     2400

ctgccctgca                                                            2410


<210> 941
<211> 618
<212> DNA
<213> Homo sapiens

<400> 941
ggacaactcg gtggtggcca ctgcgcagac cagacttcgc tcgttctcgc atgcctcgct       60

ccgcttttcc tccgcaacca tgtctgacaa acccgatatg gctgagattg agaaattcga      120

taagtcgaaa ctgaagaaga cagagatgca agagaaaaat ccactgcctt ccaaagaaac      180

gattgaacag gagaagcaag caagcgaatc gtaatgaggc gtgcaccgcc aatatgcatt      240

gtacattcca caagtattgc cttcttattt tacttctttt agctgtttaa ctttgtaaga      300

tgcaaagagg ttggatcaag tttaaatgac tatgctgccc ctttcacatc aaagaactac      360

tgacaacgaa ggctgcgcct gcctctccca tctgtctatc tggctggcag ggaaggaaag      420

aacttgcttg ttggtgaagg aagaagtggg gtgggacgac agtgaaatct agagtaaaac      480

caggctggcc caaggtgtcc tgcaggctgt aatgcagttt aatcagagtg ccattttttt      540

ttttgttcaa atgattttaa ttattggaat gcacagtttt tttaatatgc aaataaaaag      600

tttaaaaact taaaaaaa                                                    618


<210> 942
<211> 7474
<212> DNA
<213> Homo sapiens

<400> 942
ggggacggtg ggagcagatc catttccggg ttggcaaaag gggcggtggc ggcggcggcg       60

gcggcggcgg cggcggcgac ggcgagaaag agcttgccgg ggggcgagca ggacaggacg      120

aagccggagt gtaggcggca gaggattcgc tcccagagca gctgcggcca ggtatatgaa      180

tgacctaaag gtacaaataa agacggagag agaacagtgc caactgggag cagggcaaga      240

atgccaattc ctcctccccc gccaccccca cctggtcctc ctccacctcc cacatttcat      300

caggcaaaca cagagcagcc caagctgagt agagatgagc agcggggtcg aggcgccctc      360

ttacaggaca tttgcaaagg gaccaagctg aagaaggtga ccaacattaa tgatcggagt      420

gctcccatcc tcgagaagcc gaaaggaagc agtggtggct atggctctgg aggagctgcc      480

ctgcagccca agggaggtct cttccaagga ggagtgctga agcttcgacc tgtgggagcc      540

aaggatggtt cagagaacct agctggtaag ccagccctgc aaatccccag ttctcgagct      600

gctgccccaa ggcctccagt atctgccgcc agcgggcgtc ctcaggatga tacagacagc      660

agccgggcct cactcccaga actgccccgg atgcagagac cctctttacc ggacctctct      720

cggcctaata ccaccagcag tacgggcatg aagcacagct cctctgcccc tcccccacca      780

cccccagggc ggcgtgccaa cgcacccccc acacctctgc ctatgcacag cagcaaagcc      840

cccgcctaca acagagagaa acccttgcca ccgacgcctg gacaaaggct tcaccctggt      900

cgagagggac ctcctgctcc acccccagtc aaaccacctc cttcccctgt gaatatcaga      960

acaggaccaa gtggccagtc tctggctcct cctcctccgc cttaccgcca gcctcctggg     1020

gtccccaatg gaccctctag ccccactaat gagtcagccc ctgagctgcc acagagacac     1080

aattctttgc ataggaagac accagggcct gtcagaggcc tagcacctcc tccacccacc     1140

tcggcctccc catctttact gagtaatagg ccacctcccc cagcccgaga ccctcccagt     1200

cggggagcag ctcctccacc cccaccacct gtgatccgaa atggtgccag ggatgctccc     1260

cctcccccac caccataccg aatgcatggg tcagaacccc cgagccgagg aaagccccca     1320

cctccaccct caaggacgcc agctgggcca ccccctcctc ctccaccgcc cctgaggaat     1380

ggccacagag attctatcac cactgtccgg tctttcttgg atgattttga gtcaaagtat     1440

tccttccatc cagtagaaga ctttcctgct ccagaagaat ataaacactt tcagaggata     1500

tatcccagca aaacaaaccg agctgcccgt ggagccccac ctctgccacc cattctcagg     1560

tgaagcctgg cttggtcccg ttcctcagga aaaggatgga ccttctcttc ttctcagatg     1620

gtcccttcca ttcccctgaa acctgcatga gagctcctaa catgtttctc caatgcaatc     1680

aagccctaga ctccaaatgt cctcccagct cacctccatc tatgcatctc atctctggat     1740

ttggtgatca gactctatat tgacagtagg atctcaaacc ctgcatccat ccttcctcca     1800

gcaagccctg ctagccacat gaggaacaag tttccgtgtc ttctgccttc ctcttgggga     1860

aaggtgcctt gttgtgatga attaactcac tgttagggca gggtggagaa tggtactcct     1920

tccttctcct gtccactgtg ggggaagctt ggcaggtata ttatatttca tcatttagga     1980

ggctggcatg accaggactt atgggtggga ggggagcatt tttagtgaag caagaaagga     2040

gtttgccaag aagtgatctg ttttaaaggt catatttgga gaaagggcaa ggaattgggt     2100

ctgctttatt tttgggggta ttttgttttt gttctcacct gctgcccccc caccccacca     2160

ccccagggat aaattggata taaacactaa atactaatca gttgaactta acatttaata     2220

aaaagaaagg gtgaaataaa ctgaagacca ttttagaact agtcagttct ctgcagcaaa     2280

gggaacagga gccatttgaa ccctctggga cccctcaccc cactgcttca gggtgctagg     2340

ctgagggatg tttttcctcc cccttaccgc ccatgccctt gaaagaaaag tcactttttg     2400

tggagggcat cattcattcc tgattcacaa accccaaaaa cctctggtgg gagataggaa     2460

gatagggcgt gggcctgggc cttaacctca atcttgtgtc tgcctcagtc ttttctgact     2520

ggccctgaag ttgtcagtgg ctctttctgt ccttcagccc ctggaaggtg ctccaggata     2580

acaaagaagg gcaggttgaa gcccctcatg gaaggagctg gctttgtggg gctgcaaagg     2640

acttttaagt cctgcctgta ctgaagttca cagcccacct gactgagcag actcttcctg     2700

ttcctttctc taccaccctt gccttcccag gactgcacgg tttaacacag cagagtacag     2760

aagggtgaag aagtgagcag aggcttatga agatattcag atactcttct atgccaggaa     2820

gcacaaagac tttgttgaga tttgcctcag ttcagtagat cttccttggc agccagccat     2880

aggttgtttc tttgtcttcc gggtcctaaa gagcacagag aaaatggagg tccccagtct     2940

aggtaggaag ctgattggat gaggacttct ttttttccga cagcaggatg gggctcttgg     3000

gctccacaca ccagatgctt tggttttcta caactgttgc tatgtgtaga gggtgctcag     3060

agcgtggcat gagagcaagg agaccatggc tactctttga aatggatggg gaaaattagc     3120

ttaaaaattt aatcacgaga ttgcgccact gcactccagc ctgggcgaca gagccagact     3180

ccgtctcaaa aaaaaaaaaa aaaaaaaaat ttaatcacac acatcacagg cttaaactgt     3240

cttagagacc tttccagttg attggatcac aggctaggga tctgtgcatg gtgccaggtg     3300

aaacccaagt ctccccagtg ctaggtgagg gagggctcaa cgggggtaat gtgtatgggg     3360

tctgctgtcc tttgccatcc cctggaccat attaactctg ggacagacca tgattaggtc     3420

tgtcaccaaa cttttcctaa tcatttttta tgtatcattc ttctttctaa tctgttagca     3480

gttatctccc agaagtatcc ctagcatcct gaagcaaaca gaactgccgg gcgctgtggc     3540

ttatgcctgt aatctcagca atttgggagg ccgaggcggg cggatcacct gaggtcagaa     3600

gttcgagacc agcctgtcca acatggtgaa accccgtctc cactaaaaac acaaaaatta     3660

tctgggcgtg gtggcatgtg cctgtagtcc cagctactgg ggaggctgag gcaggagaat     3720

cgcttgaatc caggaggtgg aggttgcagt gagtggagat ggcgccactg cgctccagcc     3780

cgggtgacag agtgaaactc catctcagaa aacaaacaaa ccaaacaact gagagagggc     3840

atgctagtgg agggaaaagg agagagtaca agagttgata ctgcatcaga gttccagggc     3900

agatactgac aagtgactga actttgactg tgaagtcttc ccatttattt ttgaaatggg     3960

agtcgatgcc ttttgtacgt tatcaaagtg tttttttttt tttcctcctt tactcagaca     4020

tagagcatca aaatatcacg agtaaagcca aaccccagct tttcactggg gctgatatct     4080

tcctccccat ggcccactgc cccctcatat tccccagcac ttggactgtg tcacatgggt     4140

attgattgta tacttgttgt cttggcctca tgcaaaaagg cctgggtcta gatctagtca     4200

gatgagtttt ttttagagca tgttgatgat acaacacctg tttaaatgtc tgccttatat     4260

gttatttggt cccactgtta ataatagatt tattactatg tatatttact attgaagatg     4320

ggaatgtgat ctgcatagtt atcagtctat tttgtatgtt gtaaaaagct tctaatttag     4380

gtttaaggtg ggctggctac aagagcacta aaactcctca ccttttaaac tgctcttttt     4440

atctgcttgt gggaatgtcg tctctttcgt ggaagattgg gtggtctcat gttgaggctg     4500

ttgcccagtc ccattaactc ccttgtcccc ccacagaagg aagagacatt gcccagctaa     4560

gcatcaggaa gctgtgttaa aagcccttct atgggtttgg ttttgtgatg tttttcccta     4620

atgggaaaaa cgttatagtt gtttcttact gccctgtctg ggaagcaggg caaacctcca     4680

ggtttttaaa tgagctagat gcccctcttc ctcttctctg gtcactgaac ctggaccaaa     4740

gcactttgat attccaggtg tgattttctc tgtcatgggg atttgctcca ctgcagagcc     4800

ccatcatttt cacagcgtag gccaacagag tgagaaccta gggctaccct agctgatgga     4860

tgtgaggctg ctgtctacag gagctcatcc cagccctgtt aactggcagt ggcaaggata     4920

ctcgtcatcg gccattgcac tggggaactc cctcacccca tggcttccca acttgaaacc     4980

cagatttacc tccagggaga ggtgagaaaa aaattgtaaa tagacttgct aaagagcaac     5040

tcagggttgg ggtgtgtttt aattctcctg atcacttgaa ataatctgta ggctgagtgc     5100

ttatgggggt gggggagaag ggtgactcca gggtccttcc attttgtgaa gctctggggg     5160

tggagtgtgg gcatctgagg ccctatgatg gcactacatt gagctgtctg cccttccgga     5220

aacccaacct gcaatcaact gcaaatcaaa ttcttcacat tccagctaca gtctttcttt     5280

ccccattgaa tctcagtccc tggccatgtg gtcaaggtgg ctttctgtta agctacccta     5340

atttcgggaa tgggagggga gagaggaggg ccattacaac tctgccttca agactcatct     5400

cttaaaaaca aaacgaaaca aaactacaac caccatcaaa accacacgca aaaaaaaaaa     5460

aaaaaaaaaa aaggataact ttaaccgaag gaagggtttg gttccattca actccacatt     5520

cattgtgcct ttacttgcat tagatttctg tgctttcttc ctttccctct ttgaagcaat     5580

taaaatcttc cttgataact gctgtttctt tctactcttg tttctggcaa tttagtgggt     5640

tccttctcta gtggtcttaa atctcattcc actggtggca agatggggcc tagccttctt     5700

ttcacatgtc taatcttttc ctttctcatg gtgccctcca tggaagtcac agtcaacact     5760

gaataaatga ctagaatgac acgtgtgcgt gcgcacgcgt gtgcgtgtgt gtgttcatct     5820

gtctgcatgt ggatcaattt cttttagaaa ataatttatt gtatgattta ttttggagtt     5880

atattctgat tacagtgctc cctctcccaa atagcattga ttttttcccc cctctaaaat     5940

gtataatctg gtctcaggtt ggattctttg gtacatttct ctcttctgga tgccatgcag     6000

cttaattaaa accttgctta aaaacaaaaa gtgaaaattg tgtactcttg tctggaatac     6060

cgcctcaggt ggtggcacag agaggggaga aaacctttgc ctcataattt gggtaagtgt     6120

agtggtttga ttccaggtcc cttgaaaaag tagatctact gaattgggca gactcatcta     6180

tagctttctg agggtcttct ctcctcctct ccagctgtat tttgaaaatt acagttctag     6240

ttggctgggc gcgatggctc atgtctgtaa tcccagcact ttgggaggcc aaggcgggtg     6300

gatcatttga ggtcaggagt tcaagaccag cttggccaac atggtgaaac cccgtctcta     6360

ctgaaaatac aaaaattaac cggtgtcatg gcgcatgcct gtagtcccag ctactcggga     6420

ggccgaggca ggaaaatcac ttgaacccag gaggcggagg ttgcactgag ctgagatcat     6480

gccactgcac taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ttctagagtt     6540

ctagttaccc ttcctgggag attctgatgg tccttatttt attattatta ttattttttt     6600

ttgagacagg atgttgctgt catccaggct ggagtgcagt ggtgtgatca tagctcaccg     6660

cagcctccaa ctctcaagct caagtgatcc tcccacctca gcctcccgtg tagctgggac     6720

cacaggtgtg taccactatg cctggctaat tttgaaaatt tttttgtaaa gacagggtct     6780

ccctatgttg cccagactgg tctcaaattc ctgggcttaa gtgattgtcc cacctcagct     6840

tctcaaagtg ctgggattac aggcatgagc caccgcaccc agccagtcct tattttatat     6900

ttccacctaa ctcccctttg cccacgattt cagggaacct aggaggcttc ctggccttgt     6960

gaccttttcc ttgaatctct tataattctt tctacctgtg ttgcatggca gattctcaga     7020

ttgaggctaa agaaaagaag ggtggggaca aagcatacag aatgtgtgta tctgttttta     7080

tgtgggtgtt ggctgttttt cgtcactgct ttttaagctg aatcttagct ggttttcttg     7140

aactttgact ttaggtgtaa aaattcaacc agacattctc tccttactgt ggtcagctga     7200

catcataacc actaaggctt aatgagctta acttgcactt tcatcactag caaaggtctt     7260

gaagttattt ctcttactga ttcataatgg gtgtgtgtat gaatcactct cacataattt     7320

agatataaaa acctatgagg atgagggagg gaggggaaga aaaaaaagga ctcctttcat     7380

tttcatccgt acttcccaga tgggctgaat ctccgattat ttgacccatc attgttatta     7440

atatggttaa taaactacct atttattgat tgaa                                 7474


<210> 943
<211> 5503
<212> DNA
<213> Homo sapiens

<400> 943
atgaattacc cgggccgcgg gtccccacgg agccccgagc ataacggccg aggcggcggc       60

ggcggcgcct gggagctggg ctcagacgcg aggccagcgt tcggcggcgg cgtctgctgc      120

ttcgagcacc tgcccggcgg ggacccggac gacggcgacg tgcccctggc cctgctgcgc      180

ggggaacccg ggctgcattt ggcgccgggc accgacgacc acaaccacca cctcgcgctg      240

gacccctgcc tcagtgacga gaactatgac ttcagctccg ccgagtcggg ctcctcgctg      300

cgctactaca gcgagggtga gagcggcggc ggcggcagct ccttgtcgct gcacccgccg      360

cagcagcctc cgctggtccc gacgaactcg gggggcggcg gcgcgacagg agggtccccc      420

ggggaaagga aacgtacccg gcttggcggc ccggcggccc ggcaccgcta tgaggtagtg      480

acggagctgg gcccggagga ggtacgctgg ttctacaagg aggacaagaa gacctggaag      540

cccttcatcg gctacgactc gctccgcatc gagctcgcct tccggaccct gctgcagacc      600

acgggtgccc ggccccaggg cggggaccgg gacggcgacc atgtgtgctc ccccacgggc      660

ccagcctcca gttccggaga agatgacgat gaggaccgcg cctgcggctt ctgccagagt      720

acgacggggc acgagccgga gatggtggag cttgtgaaca tcgagcctgt gtgcgtgcgg      780

ggcggcctct acgaggtgga tgtgacccaa ggagagtgct acccggtgta ctggaaccag      840

gctgataaaa taccagtaat gcgtggacag tggtttattg acggcacttg gcagcctcta      900

gaagaggaag aaagtaattt aattgagcaa gaacatctca attgttttag gggccagcag      960

atgcaggaaa atttcgatat tgaagtgtca aaatccatag atggaaaaga tgctgttcat     1020

agtttcaagt tgagtcgaaa ccatgtggac tggcacagtg tggatgaagt atatctttat     1080

agtgatgcaa caacatctaa aattgcaaga acagttaccc aaaaactggg attttctaaa     1140

gcatcaagta gtggtaccag acttcataga ggttatgtag aagaagccac attagaagac     1200

aagccatcac agactaccca tattgtattt gttgtgcatg gcattgggca gaaaatggac     1260

caaggaagaa ttatcaaaaa tacagctatg atgagagaag ctgcaagaaa aatagaagaa     1320

aggcattttt ccaaccatgc aacacatgtt gaatttctgc ctgttgagtg gcggtcaaaa     1380

cttactcttg atggagacac tgttgattcc attactcctg acaaagtacg aggtttaagg     1440

gatatgctga acagcagtgc aatggacata atgtattata ctagtccact ttatagagat     1500

gaactagtta aaggccttca gcaagagctg aatcgattgt attccctttt ctgttctcgg     1560

aatccagact ttgaagaaaa agggggtaaa gtctcaatag tatcacattc cttgggatgt     1620

gtaattactt atgacataat gactggctgg aatccagttc ggctgtatga acagttgctg     1680

caaaaggaag aagagttgcc tgatgaacga tggatgagct atgaagaacg acatcttctt     1740

gatgaactct atataactaa acgacggctg aaggaaatag aagaacggct tcacggattg     1800

aaagcatcat ctatgacaca aacacctgcc ttaaaattta aggttgagaa tttcttctgt     1860

atgggatccc cattagcagt tttcttggcg ttgcgtggca tccgcccagg aaatactgga     1920

agtcaagacc atattttgcc tagagagatt tgtaaccggt tactaaatat ttttcatcct     1980

acagatccag tggcttatag attagaacca ttaatactga aacactacag caacatttca     2040

cctgtccaga tccactggta caatacttca aatcctttac cttatgaaca tatgaagcca     2100

agctttctca acccagctaa agaacctacc tcagtttcag agaatgaagg catttcaacc     2160

ataccaagcc ctgtgacctc accagttttg tcccgccgac actatggaga atctataaca     2220

aatataggca aagcaagcat attaggggct gctagcattg gaaagggact tggaggaatg     2280

ttgttctcaa gatttggacg ttcatctaca acacagtcat ctgaaacatc aaaagactca     2340

atggaagatg agaagaagcc agttgcctca ccttctgcta ccaccgtagg gacacagacc     2400

cttccacata gcagttctgg cttcctcgat tctgcatatt tcagacttca agaatcgttc     2460

tttaatctcc cacaacttct ttttccggaa aatgtaatgc agaataaaga taatgccctc     2520

gtggagttgg atcacaggat tgattttgaa ctcagagaag gccttgtgga gagccgctat     2580

tggtcagctg tcacgtcgca tactgcctat tggtcatcct tggatgttgc cctttttctt     2640

ttaaccttca tgtataaaca tgagcacgat gatgatgcaa aacccaattt agatccaatc     2700

tgaactctct tgaaggacat gaatggccta aaactgattt tttttttttc cgttaaaatg     2760

tgtgtgtcaa gatacggaga tttcagggtt aaagtatatt tcagttttct ttagggcaac     2820

atatatttga atttaaaagc actttattta aaaaaaaaag aagttttcag ttctgaagaa     2880

gtcatttaca gtttgcatca ttttaattat gagtctgaca aaaccttctc cagagaatca     2940

agcaagacct ggatgtgaag aaggtttggg taaactgcat gtaaaggcta caaatcacaa     3000

tctgattcct cccaaatata aaggcatatg gaacataatg tattaaccaa agtatgttat     3060

aaatcaaaaa tggtcaaggt tcagcatatt ctatatgaag atcacaaggt ggtatcgttt     3120

tagatttcta tgaaggcttt catttgtaca tccctttgaa aaaatataac agatttaaaa     3180

tgttttgaat ttaacttgtt tagaaaaact aatgcttaaa acaatatttg aactactgta     3240

tttataattt attacctcta attgctttat ttcagtgtat gagacattac tgttttaatg     3300

tttgctttga acataattta agaaccagat ttattttcta tagtgataaa cccttttttc     3360

tcagaactcc atctttgtac tcttcagatg aatatataga cactgtggca tacatttttt     3420

ttcattaaaa acttatggct tcatacaaca ctagttcaat tttttaaata aactttttat     3480

tatgttacat gtacttcaga gaaagctaaa gtttctctaa acttgacacg gagtactcca     3540

taatgggtac atttcattag ctttattaga aaactagtaa atgcttttga ataggtagta     3600

tgacagctat tttaaatgta taaacatttg tgtgccaaac aacatatatg aagggatgtg     3660

atgccactaa ctagtgcaca ttgtttctca atgtgccatt gagacacaag gcacagtaag     3720

tcaggattct gaggcattgg aagggttttc ttcagctgta attgtttcca cagtgctttt     3780

catctgaggg gctcaaagtt taagagtgca ttcaataacc catgtactag cttcttgagg     3840

taagtaaata aatcttgttc tcatgttaca tgttaataca ccaaggcacc aaaacattta     3900

aagtgccatg aattagatta catcagaaat cagaaaagct tggattgagc tagtcaccgt     3960

ggttcacgcc tgtaatccca acacttcggg aggccaagat gggaggatct cttgagccca     4020

ggatttcaag accagcttgg gcaacatagt gagaccctct tctctgcaaa aactgacaaa     4080

aattagccac ttgtagtggt gtacacctgt agtcccagct actcaagagg ctgaggtggg     4140

aggatcaccc gagcccagaa gttcaaagct gcagtgagct ctgatcacac caatgcactc     4200

cagcctgggt gacagagcca gaccctgtct ctaaaaaaca aaaaagaaaa gcttgggttg     4260

aagccaggcc atattctttt atatgctgtt caatgacttg attcacatgt gaccttttag     4320

tagtttgcaa acaataataa cagaagttgc aattcataat tcagagaaat gaccatgaag     4380

ccggtgtttc cctgcttgat ttctatgttc ttggattctc acacaaaaga ggagttacct     4440

agaggggatc agtagccatc cctgttgcac acaaccctca cttctgagtg gtttccacta     4500

ggttccactt aaggtgctgt cttttcttaa cttgcaagga attgcttagc ttcccaataa     4560

tcattgtcaa actgggagca aagttggtca gctgtatctc tcacctcctc ctttcttcat     4620

aagatagtag aatctgtggc ttacttgtag gttttactta gtgcttcagt actgttggct     4680

gttttggcct tttgctgaat ttgcacaaca acataaagca cttcttttta atgtttaaaa     4740

aaaattccaa ggctccatga ccaagtatgt gactcactaa gaaacccttg ctataaaagg     4800

cttttgatga aatcttagca aagctaaatt atctctaact tagagattcc tatgaactca     4860

ggtcattttc atagcctgtt tattttgtag gtctaattta gttctcagga aaattaaact     4920

catgctatat gactgtatcg ttaaaggtac ttgagcgtat gttgctgtag gtggtatgac     4980

actcaaatgc ataagaactt gaagggattt attcttaacc actagaatat gaagagccct     5040

ttttacctga gaagagtgaa attatgtcag accttttaat ttgatatcac tgagtaaaag     5100

gtatgttcct atagccatag gaatatgtct gcttcctttt tttcatgttg agaaaacagt     5160

caaatttaac catttggagt ttatttgaat tcttggaaag agcaatattc aaaacctttt     5220

caaaaataag atattctgga ctactggatg gatgttttgt tttcagttca tttttcatca     5280

gtagagatgg tgatttcggt tttgtagtat ccttgtttct atgtctgtgc atgttaacat     5340

tggatgtatt tgtatatact taattaatat acagactgtg tgtcattctg gcttgattag     5400

aagctaagtc agttactgag taacattttg caactttatt ccagcaagta ctaaatcggc     5460

caaaaaaagt tttgtttttg ataccattaa aattttattc tct                       5503


<210> 944
<211> 1510
<212> DNA
<213> Homo sapiens

<400> 944
gaggaagtag acaaacctaa atatgtgtct gaactccaag gaatatgaac aagatgcctg       60

ctggtgaaca agaatgtgaa tataacaaag aagggaagta ctactctaaa ggagttaaac      120

tggtgagaaa aaagaaaaaa attcctggtt accgttgggg ggacattaag ataaacatca      180

taggtgaaaa ggatgattta ccaattcatt tctgtgacaa atgtgatttg cctattaaaa      240

tctatgggcg aataattccg tgcaagcatg ctttttgcta tcactgtgct aatttatatg      300

acaaagtcgg atataaagta tgtccgcgct gtcgttatcc tgtgctgaga attgaggcgc      360

ataaacgagg ttctgtcttc atgtgtagta ttgttcagca gtgcaagaga acatacttgt      420

ctcagaaaag cttacaggct catatcaaac gccgccataa gagagctcga aaacaagtta      480

ccagcgcttc gcttgaaaaa gttcgtcctc atattgctcc gccacaaact gaaatctctg      540

acatccctaa aagactgcaa gacagggacc atctaagcta tattccacca gaacagcaca      600

ccatggtgtc actaccgtct gtgcaacata tgctacaaga gcaacataat cagccacata      660

aggatatcca ggctcctccc ccagaactat ctctaagtct gccttttccc atccagtggg      720

aaaccgttag tatttttacg agaaaacatg gcaatttaac agttgatcat attcagaata      780

actcagattc tggtgctaag aagccaacac ctcccgacta ttatcctgag tgtcaaagtc      840

aaccagcggt atcgtcccct catcatatta tacctcagaa acagcattat gcgccacctc      900

catctccatc atcaccagta aaccatcaaa tgccatatcc tcctcaggat gtagttactc      960

ctaactcggt tcgtagccaa gtgccagctc taaccacgac ctacgatcca tcatctggat     1020

atattattgt aaaggtgcca cctgatatga attctcctcc actacgtgct ccccagtctc     1080

aaaatggtaa tccatctgca agtgaatttg cttctcacca ttataacctt aacattttac     1140

ctcagttcac cgaaaatcaa gaaaccttga gccctcagtt tacacaaaca gatgcaatgg     1200

atcatagaag gtggcctgca tggaaacgac tgtcaccttg tccaccaacg cggagtccac     1260

ctccttcaac cctacatggt cgatcacatc attcacacca gagaagacat agacggtatt     1320

aaggatgata acagtatttg gaactgaaga cctgatggga aaaaaacctt caagttctat     1380

actgtactgt ggataagcgg ctcagttcag cagagctgga gttgaacaac tttgttcctc     1440

tggtgtggta aattgaccta aaggtgacct ctgacgattt cctgaaataa atatgcaatg     1500

ttacattttc                                                            1510


<210> 945
<211> 3568
<212> DNA
<213> Homo sapiens

<400> 945
atagttttca ggttaagaaa gccagaatct ttgttcagcc acactgactg aacagacttt       60

tagtggggtt acctggctaa cagcagcagc ggcaacggca gcagcagcag cagcagcagc      120

agcagcagca gcagggctcc tgggataact caggcatagt tcaacactat gggtcctcct      180

ctgaagctct tcaaaaacca gaaataccag gaactgaagc aggaatgcat caaagacagc      240

agacttttct gtgatccaac atttctgcct gagaatgatt ctcttttcta caaccgactg      300

cttcctggaa aggtggtgtg gaaacgtccc caggacatct gtgatgaccc ccatctgatt      360

gtgggcaaca ttagcaacca ccagctgacc caagggagac tggggcacaa gccaatggtt      420

tctgcatttt cctgtttggc tgttcaggag tctcattgga caaagacaat tcccaaccat      480

aaggaacagg aatgggaccc tcaaaaaaca gaaaaatacg ctgggatatt tcactttcgt      540

ttctggcatt ttggagaatg gactgaagtg gtgattgatg acttgttgcc caccattaac      600

ggagatctgg tcttctcttt ctccacttcc atgaatgagt tttggaatgc tctgctggaa      660

aaagcttatg caaagctgct aggctgttat gaggccctgg atggtttgac catcactgat      720

attattgtgg acttcacggg cacattggct gaaactgttg acatgcagaa aggaagatac      780

actgagcttg ttgaggagaa gtacaagcta ttcggagaac tgtacaaaac atttaccaaa      840

ggtggtctga tctgctgttc cattgagtct cccaatcagg aggagcaaga agttgaaact      900

gattggggtc tgctgaaggg ccatacctat accatgactg atattcgcaa aattcgtctt      960

ggagagagac ttgtggaagt cttcagtgct gagaaggtgt atatggttcg cctgagaaac     1020

cccttgggaa gacaggaatg gagtggcccc tggagtgaaa tttctgaaga gtggcagcaa     1080

ctgactgcat cagatcgcaa gaacctgggg cttgttatgt ctgatgatgg agagttttgg     1140

atgagcttgg aggacttttg ccgcaacttt cacaaactga atgtctgccg caatgtgaac     1200

aaccctattt ttggccgaaa ggagctggaa tcggtgttgg gatgctggac tgtggatgat     1260

gatcccctga tgaaccgctc aggaggctgc tataacaacc gtgatacctt cctgcagaat     1320

ccccagtaca tcttcactgt gcctgaggat gggcacaagg tcattatgtc actgcagcag     1380

aaggacctgc gcacttaccg ccgaatggga agacctgaca attacatcat tggctttgag     1440

ctcttcaagg tggagatgaa ccgcaaattc cgcctccacc acctctacat ccaggagcgt     1500

gctgggactt ccacctatat tgacacccgc acagtgtttc tgagcaagta cctgaagaag     1560

ggcaactatg tgcttgtccc aaccatgttc cagcatggtc gcaccagcga gtttctcctg     1620

agaatcttct ctgaagtgcc tgtccagctc agggaactga ctctggacat gcccaaaatg     1680

tcctgctgga acctggctcg tggctacccg aaagtagtta ctcagatcac tgttcacagt     1740

gctgaggacc tggagaagaa gtatgccaat gaaactgtaa acccatattt ggtcatcaaa     1800

tgtggaaagg aggaagtccg ttctcctgtc cagaagaata cagttcatgc catttttgac     1860

acccaggcca ttttctacag aaggaccact gacattccta ttatagtaca ggtctggaac     1920

agccgaaaat tctgtgatca gttcttgggg caggttactc tggatgctga ccccagcgac     1980

tgccgtgatc tgaagtctct gtacctgcgt aagaagggtg gtccaactgc caaagtcaag     2040

caaggccaca tcagcttcaa ggttatttcc agcgatgatc tcactgagct ctaaatctgc     2100

aatcccagag aatcctgaca aagcgtgcca cccttttatt ttccgtcagg tgccaggtct     2160

tagttaagat tcacaatctt tagaaagaat gagattcaca ataattaact cttcctctct     2220

tctgataaat tccccatacc tcccaatcca agtagcatct gtagctacat aacctatata     2280

cctccagcag ctggacatgg ggaggcgaca gtcctatcta gacatcatac acatttgcca     2340

agaaaggatc tctggggctt ccgggggtga gattcaagta ggacaataac aagaggctgg     2400

acaccctaca gatgtctttg atgttttcag ttgtttgata tatctcccct gtagggcatg     2460

ttgaggaagg aggagggctg atcaaggcca agctggtcta gcctgacatc ctagctcctg     2520

actgaacact atagacttcc cagcagcatt tcacccagca gccagagccg gctttaagtc     2580

cccaaccctt acagacacca ctgccaccac caccaaccac gaccaccacc accaccacca     2640

ctcaccacca tcatcacctc cggaaagtgt agtcctgccc taacccaagt cacccccgac     2700

agtaaatttt accttcatgt tgagaaagct tcctggtgct taatcaagag ctggagttca     2760

atgagtccta gacagtgaga ggggcctgag cttcagctca atggaagcct gctgtgtgcc     2820

acaagacgga aaagtggaag aagctgcagt gggagacaaa gcctcggtcc cccacccatc     2880

cacacacacc tacactcaca cacgcgcaca tgggcgcgca cgaactacca ttcaggcagt     2940

cagtgggcaa gaggaaagat aagtaagtac catacacacc taaaagatga gagaattcat     3000

ccagacatat tacagccagt ttggggcccc tgactgcaat gtgaaacctc tcgctgctgc     3060

taggtttaca aacaagccca ttgtcctgtg cctcctaata tcatttgtac tgaagacccc     3120

atctggggac ttgagacttt ggtcccagcc cagactcctc agacttttct ctcagttggg     3180

atgcttcact cgctgggggt gtttgtttgc cctctcattt ttcagtactt ctacagaatt     3240

ttctctagag tcagtcatta tgaaatgtac ttccctccat cttaacctat caactttctg     3300

cccctccttc aaggcccagt ataaatgcca cctcctccat gaagccttcc ctaattccac     3360

cccaaacccc caccttcaac aatatttcaa cgcttctgca atgatgaaaa agaaacatag     3420

ttgtagtact tagcctacct agaccagcaa gcattcattt ttagctcgct cattttttac     3480

catgttttcc agtctgttta acttctgcag tgccttcact acactgcctt acataaacca     3540

aatcacaata aagttcatat tcagtaca                                        3568


<210> 946
<211> 3286
<212> DNA
<213> Homo sapiens

<400> 946
gaacgccggg gcggcccgaa gatggcggcg gtggctggat ctggggctgc cgcggctccg       60

agctcactgc tcctcgtggt gggcagcgag ttcgggagcc cggggctcct cacctacgtc      120

ctggaggagc tcgaaagagg catccggtct tgggatgtcg atcctggcgt ctgcaacctt      180

gatgaacagc tcaaggtctt tgtgtcccga cactctgcca ccttctccag cattgtgaaa      240

ggccagcgga gcctgcacca ccgtggagac aacctggaga ccctggtcct cctgaaccca      300

tcagacaagt ccctgtatga tgagctccgg aaccttctgt tggaccctgc ctctcacaag      360

ctactggtgt tggctgggcc ctgcctggag gagacggggg agctgctgct acagacaggg      420

ggcttctcgc ctcaccactt cctccaggtc ctgaaggaca gagagatccg ggacatcctg      480

gccaccacgc ccccacctgt gcagccgccc atactcacca tcacctgccc caccttcggt      540

gactgggctc agctggcacc cgctgtgcct ggccttcagg gggcgctccg gctccagctg      600

cggctgaacc ccccggcgca gctgcccaac tctgagggcc tgtgcgaatt cctggagtac      660

gtggctgagt ctctggagcc accgtccccc ttcgagctgc tggagccccc gacctccggg      720

ggcttcctca ggctgggccg gccctgctgc tacatcttcc ctggaggcct cggggatgcc      780

gccttcttcg ccgtcaatgg cttcactgtg ctggtcaacg gtggctcaaa ccccaagtcc      840

agtttctgga agctggtgcg gcacctggac cgcgtggatg ccgtgctggt gacccaccct      900

ggcgccgaca gcctccccgg cctcaacagc ctgctgcggc gcaaactggc ggagcgctcc      960

gaggtggctg ctggtggggg ctcctgggac gacaggctgc gcaggctcat ctcccccaac     1020

ctgggggtcg tgttcttcaa cgcctgcgag gccgcgtcgc ggctggcgcg cggcgaggat     1080

gaggcggagc tggcgctgag cctcctggcg cagctgggca tcacgcctct gccactcagc     1140

cgcggccccg tgccagccaa acccaccgtg ctcttcgaga agatgggcgt gggccggctg     1200

gacatgtatg tgctgcaccc gccctccgcc ggcgccgagc gcacgctggc ctctgtgtgc     1260

gccctgctgg tgtggcaccc cgccggcccc ggcgagaagg tggtgcgcgt gctgttcccc     1320

ggttgcaccc cgcccgcctg cctcctggac ggcctggtcc gcctgcagca cttgaggttc     1380

ctgcgagagc ccgtggtgac gccccaggac ctggaggggc cggggcgagc cgagagcaaa     1440

gagagcgtgg gctcccggga cagctcgaag agagagggcc tcctggccac ccaccctaga     1500

cctggccagg agcgccctgg ggtggcccgc aaggagccag cacgggctga ggccccacgc     1560

aagactgaga aagaagccaa gaccccccgg gagttgaaga aagaccccaa accgagtgtc     1620

tcccggaccc agccgcggga ggtgcgccgg gcagcctctt ctgtgcccaa cctcaagaag     1680

acgaatgccc aggcggcacc caagccccgc aaagcgccca gcacgtccca ctctggcttc     1740

ccgccggtgg caaatggacc ccgcagcccg cccagcctcc gatgtggaga agccagcccc     1800

cccagtgcag cctgcggctc tccggcctcc cagctggtgg ccacgcccag cctggagctg     1860

gggccgatcc cagccgggga ggagaaggca ctggagctgc ctttggccgc cagctcaatc     1920

ccaaggccac gcacaccctc ccctgagtcc caccggagcc ccgcagaggg cagcgagcgg     1980

ctgtcgctga gcccactgcg gggcggggag gccgggccag acgcctcacc cacagtgacc     2040

acacccacgg tgaccacgcc ctcactaccc gcagaggtgg gctccccgca ctcgaccgag     2100

gtggacgagt ccctgtcggt gtcctttgag caggtgctgc cgccatccgc ccccaccagt     2160

gaggctgggc tgagcctccc gctgcgtggc ccccgggcgc ggcgctcggc ttccccacac     2220

gatgtggacc tgtgcctggt gtcaccctgt gaatttgagc atcgcaaggc ggtgccaatg     2280

gcaccggcac ctgcgtcccc cggcagctcg aatgacagca gtgcccggtc acaggaacgg     2340

gcaggtgggc tgggggccga ggagacgcca cccacatcgg tcagcgagtc cctgcccacc     2400

ctgtctgact cggatcccgt gcccctggcc cccggtgcgg cagactcaga cgaagacaca     2460

gagggctttg gagtccctcg ccacgaccct ttgcctgacc ccctcaaggt ccccccacca     2520

ctgcctgacc catccagcat ctgcatggtg gaccccgaga tgctgccccc caagacagca     2580

cggcaaacgg agaacgtcag ccgcacccgg aagcccctgg cccgccccaa ctcacgcgct     2640

gccgccccca aagccactcc agtggctgct gccaaaacca aggggcttgc tggtggggac     2700

cgtgccagcc gaccactcag tgcccggagt gagcccagtg agaagggagg ccgggcaccc     2760

ctgtccagaa agtcctcaac ccccaagact gccactcgag gcccgtcggg gtcagccagc     2820

agccggcccg gggtgtcagc caccccaccc aagtccccgg tctacctgga cctggcctac     2880

ctgcccagcg ggagcagcgc ccacctggtg gatgaggagt tcttccagcg cgtgcgcgcg     2940

ctctgctacg tcatcagtgg ccaggaccag cgcaaggagg aaggcatgcg ggccgtcctg     3000

gacgcgctac tggccagcaa gcagcattgg gaccgtgacc tgcaggtgac cctgatcccc     3060

actttcgact cggtggccat gcatacgtgg tacgcagaga cgcacgcccg gcaccaggcg     3120

ctgggcatca cggtgttggg cagcaacagc atggtgtcca tgcaggatga cgccttcccg     3180

gcctgcaagg tggagttcta gccccatcgc cgacacgccc cccactcagc ccagcccgcc     3240

tgtccctaga ttcagccaca tcagaaataa actgtgacta cacttg                    3286


<210> 947
<211> 6400
<212> DNA
<213> Homo sapiens

<400> 947
aggggcggag gtgacagcgg gctggggact ggcggctgca actgcctgcc gcgccgaggg       60

accgccgggc ggcggaaagc aggttataaa acatggaggc tggctcagtg gttcgagcca      120

tttttgactt ctgccctagc gtatcagaag aactgccgct ctttgtggga gatattattg      180

aggtgctggc agtggtggat gaattttggc ttctaggaaa gaaggaggat gttacaggac      240

aattccccag cagttttgtg gaaattgtga ccattcccag tctaaaagag ggagagaggc      300

tgtttgtgtg catttgtgaa ttcacatccc aagagttgga taatcttccc ctccatcgag      360

gtgacctggt gattctcgat ggcattccca ctgcaggctg gctgcagggc cgaagctgct      420

ggggcgcacg gggcttcttc ccatcttcat gtgtccgcga gctctgcctc tcctcacaga      480

gccggcagtg gcactcccag agcgccctgt ttcagattcc ggaatattcc atgggacaag      540

cccgggccct aatggggctt tctgctcagc tggatgaaga gctggacttc agggaagggg      600

atgtgatcac cattattgga gttcctgaac caggctggtt tgaaggggag ttagagggcc      660

gaagaggcat ttttccagaa ggttttgtag agctgttggg gcccctgagg actgtggatg      720

agtcagtaag ttctggaaat caagatgact gcattgttaa tggtgaagta gatacccctg      780

taggagaaga agagataggg ccggatgagg atgaggagga gccagggacc tatggggtcg      840

ccctgtacag attccaagcc ctggagccaa atgagctgga tttcgaggtc ggggataaaa      900

tccgaattct ggcgaccttg gaagatggct ggctggaagg atccctgaag ggcaggacag      960

gcatctttcc ttaccggttt gtgaaattat gtcctgacac acgggtggag gaaaccatgg     1020

ctctgcccca ggaaggcagc cttgccagga tcccggaaac ttctttggat tgtttggaga     1080

acaccttagg agtagaggaa caaagacatg aaaccagtga ccatgaggcc gaggagcctg     1140

actgcattat ttctgaagca cccacttctc ccctcggtca tctgacttca gagtatgaca     1200

cagacagaaa ctcttatcag gacgaggaca ccgcaggagg gcccccgaga agcccaggcg     1260

tggagtggga aatgcctctt gccacagact ctcccacatc tgaccctaca gaagtagtca     1320

atggtatttc ctcccaacct caggtccctt ttcatcccaa cttgcagaaa agccagtatt     1380

attctacagt gggagggagc cacccgcact cagaacagta ccccgacctt cttcccctag     1440

aagcaaggac tagagactat gccagcctac ctcccaaaag aatgtattcc cagctaaaaa     1500

ctcttcagaa gccagtgctc cctctttaca ggggctcttc tgtttcagct tcaagggtag     1560

tcaaacccag acaatcaagt cctcagctcc acaacctagc aagttatact aaaaagcacc     1620

acacgtccag tgtttactcc atctcagaga gattggagat gaagcctggt ccgcaagccc     1680

aagggcttgt tatggaagca gcaacacatt cacagggaga cggcagcact gacctggact     1740

cgaagctgac acaacagctg atcgagtttg agaagagctt ggcagggccc ggcacagagc     1800

cagataaaat tttacgccac ttttcaatca tggactttaa ctctgagaag gatattgtcc     1860

gaggttcctc aaagttaatc accgagcagg agctgccgga aaggagaaag gccctaaggc     1920

caccgccacc tcgtccctgt actccggtat ccacttctcc ccatttgctg gttgaccaga     1980

acctaaaacc tgcaccaccc ttggtggtgc gaccctctcg cccagctccc ctgcctccct     2040

cagcacagca gagaacgaat gcggtatccc ccaagctcct atctcgacac cgtcctacct     2100

gtgagacctt agaaaaggag ggccctggtc atatgggaag gagtctggac cagacctccc     2160

catgcccctt agtgctggtg aggattgagg aaatggagcg ggacttggat atgtacagta     2220

gagctcaaga agagctaaac ctcatgctgg aggagaagca ggatgaatca tcaagagcag     2280

agaccctcga ggatctcaag ttctgtgaaa gtaacattga aagtttgaat atggaactcc     2340

agcaactaag agaaatgacg ctcctctcct cccagtcttc atcactggtg gccccttctg     2400

ggtctgtgtc tgccgaaaat ccagagcaga ggatgctgga gaagagagcc aaggtcatag     2460

aagaacttct tcagacagaa agagactaca ttcgggatct ggaaatgtgt attgagcgga     2520

tcatggtacc catgcagcag gcacaggtac caaacattga ttttgaggga ctttttggaa     2580

atatgcagat ggtgattaag gtctcgaagc aattattggc tgctctggaa atcagcgatg     2640

ctgtaggacc tgtgtttctt ggtcaccggg atgagcttga gggaacatac aagatttact     2700

gccagaatca tgatgaggcc attgcgctgc ttgaaatcta cgagaaggat gagaagatcc     2760

agaagcatct tcaggactcc ttggcagatc tgaagagcct atacaacgaa tggggatgca     2820

caaattatat taacctgggc tccttcctca tcaaaccagt acagagagta atgcgttacc     2880

cgctgttgct aatggagttg ctgaattcca ccccagaatc ccacccagat aaagtgcctt     2940

taaccaatgc agtccttgcg gtcaaggaaa tcaacgttaa cattaatgaa tataaacggc     3000

gaaaggacct ggtcctcaag taccgtaagg gtgatgaaga tagccttatg gagaaaattt     3060

ccaaactgaa catccactcc atcatcaaga aatccaaccg agttagcagt cacctgaagc     3120

atctcactgg ctttgctcct cagataaaag atgaagtatt tgaagaaaca gaaaaaaact     3180

tccgaatgca agaaagattg attaagtctt ttatccgaga cctgtctctc tacctccagc     3240

acatccggga gtccgcatgt gtgaaagtgg tggctgctgt gagcatgtgg gatgtgtgca     3300

tggagagagg acaccgggac ctggagcagt ttgagagggt gcatcgctac atcagtgacc     3360

agctcttcac aaactttaag gagaggacag agcggcttgt catctccccc ttaaatcagt     3420

tactgagcat gtttacaggg ccccataagc tggtacagaa acgctttgac aagctcctgg     3480

acttctataa ctgtacagaa cgggcagaaa agctaaagga caagaagacc ctggaggagc     3540

tgcagtcggc ccggaacaac tatgaggccc tgaatgcaca gctgctggat gagctgccca     3600

agttccacca gtacgcccag ggcctcttca ccaactgtgt ccacggctat gctgaagccc     3660

actgtgactt tgtgcaccag gctctggagc aattaaagcc actgctttcg ttactcaaag     3720

tggctggcag agagggaaac cttattgcca tcttccacga agagcacagc agagttctgc     3780

agcaactcca ggtttttacc ttcttcccgg agtctcttcc agctaccaag aagccatttg     3840

agaggaaaac cattgaccgc cagtctgctc gaaagccact cctgggcctg ccaagttaca     3900

tgctacagtc agaagaactc cgggcctccc tcctggccag gtatccccct gaaaaactct     3960

tccaggcaga acggaacttc aatgctgctc aagacttgga tgtctcactt ttggaaggtg     4020

acctggtggg tgtgattaag aaaaaagacc ccatgggcag ccagaaccgc tggctgattg     4080

acaatggagt caccaaaggc ttcgtgtaca gctctttcct aaagccctac aatcctcgcc     4140

gcagccactc cgatgcctcc gtgggtagcc actcctccac agagtctgag cacggcagct     4200

cctcccccag gttcccacgc cagaacagcg gcagcaccct gaccttcaac cccagcagca     4260

tggctgtatc ctttacctcg gggtcttgcc agaagcagcc tcaagatgca tctcctccgc     4320

caaaagaatg tgaccaagga actctcagtg catccctaaa tccgagtaat tcagagagta     4380

gtccttccag atgcccttca gacccagact ccacctccca gccaaggtca ggggactctg     4440

cagatgtagc tagagatgta aagcaaccca ctgccacgcc gaggagctac cggaacttca     4500

ggcatccaga aatagttggc tactccgtac caggacgaaa tgggcaaagt caagacctcg     4560

tcaaaggatg tgcaagaaca gcccaggctc cggaagacag aagtacagag ccagatggca     4620

gtgaggcaga aggcaaccag gtctattttg ctgtctacac cttcaaggca cgaaacccaa     4680

atgagctgag cgtgtcagcc aatcagaaac tcaagatcct cgagtttaaa gatgttacag     4740

gaaatacaga gtggtggtta gctgaggtta acgggaagaa gggctacgtt ccctccaatt     4800

atatccgcaa aaccgagtac acctgagccc acgttgcctg ccacccagcc ttgctgcctt     4860

tgctttcagt ccgccgaggg ttctggcggc ccaccgagag ggcgcctgct cctgagacac     4920

aggccctgtc tgcgttgctt aaccatggca tggtggagca caccacagat cttgttctcc     4980

tcgattgggt tgtaaacctt gatgctcact agaatctcta gaatttgaaa tggaccctgg     5040

ggctttgcaa atgacttagt gactatgaga agagagacaa gtcttagagc tggcttttgg     5100

aaaggagaaa cttgcagtca gaagcccagt gtcctatgta tgcaggaagc tgtgctctag     5160

caatagacag tgttggtaat ggttgtgctg tacggcgttt ggggtggccc catgttccat     5220

gctcagctga ccggatgcca actcagatga aaagaattca tggctctggg caccccgtga     5280

ggcagtgctt gcacatggct gggagtttgt cgggattgaa ccaaacctag tgcttcaaag     5340

ctcctgggac acctccagtg tccagcacac attctcatac atactgcccc taatttctaa     5400

agtccctaaa gcactacatt ctgtaacctt gtttctttta ctccattccc agattagtta     5460

tgcaaaattc aactgcgttc tacttttaga agtgtttagg gtctttattt tctgttgacc     5520

cttcatctga aagattctct tcccttgtta ggtacaatca ctgccccccc gctttttttt     5580

ttgagatggg gtcttgctat gttgcccagg ctggtcttaa acgcctgggc tcaagcaacc     5640

ctcccgcctc cctgctgaga ttacaggtgt aagccaccat accgcaacct caatgacacc     5700

tttctgatgg tctttacaca gtctgtgatg tctggtggcc cccctgccct ggactcaata     5760

attgatagat tttcctagag taacagtatg agagctccag ccattccatt aaaagtatta     5820

gttctgcttt gagctgaaac cagttgagcc taatggaaga ctggatgtct ttcttcttca     5880

tccaagcacc ctaatgactg tttagttaca tccatagatg cagacaacat aacacctgtg     5940

acttacttga attgggataa gccattccag aagtagctta tcctagactt ggaaataaga     6000

tttttttcac cactaacttc catgcttcag agatgacatt caaagccaga ttcccaagtg     6060

cctgatcata cctcccagtc tcaggaagat atttgcttac cccttagacc aagaatctta     6120

agatcttccc cagctatgaa gcctatcttg gaatgggaaa ccatgaaatt tgtcttttaa     6180

aagaaaggga agaaatagcc ttacagcccc tgttcctcca agtgcacatt tagccttaaa     6240

atcctgggag tcgggagaca ccgtggagtc ctaacatcca cagtgtctgc tggtcgtggt     6300

cagaaggcag taatgcaaga gtccttttgt gaagagtgtt tctatgtaga gatgtttata     6360

tttaagtagt tcttttataa ataaaagcat ttctaatggc                           6400


<210> 948
<211> 3801
<212> DNA
<213> Homo sapiens

<400> 948
ttcagcaaaa ggtctttcct cccttgctct ctcctccaac cactggctca gcctctccgc       60

ccgctgcctg tgaatgatgc aatggaaggt gtgctggggt cgccctgtgt cccgtgcata      120

ggagcatctc agcctccagg tcctctcctt tggggctcac ggcaccccca tgctacgaac      180

cgcaggcagg gacggcctct gtcgcctgtc cacctacttg gaagaactcg aggctgtgga      240

actgaagaag ttcaagttat acctggggac cgcgacagag ctgggagaag gcaagatccc      300

ctggggaagc atggagaagg ccggtcccct ggaaatggcc cagctgctca tcacccactt      360

cgggccagag gaggcctgga ggttggctct cagcaccttt gagcggataa acaggaagga      420

cctgtgggag agaggacaga gagaggacct ggtgagggat accccacctg gtggcccgtc      480

ctcacttggg aaccagtcaa catgccttct ggaagtctct cttgtcactc caagaaaaga      540

tccccaggaa acctacaggg actatgtccg caggaaattc cggctcatgg aagaccgcaa      600

tgcgcgccta ggggaatgtg tcaacctcag ccaccggtac acccggctcc tgctggtgaa      660

ggagcactca aaccccatgc aggtccagca gcagcttctg gacacaggcc ggggacacgc      720

gaggaccgtg ggacaccagg ctagccccat caagatagag accctctttg agccagacga      780

ggagcgcccc gagccaccgc gcaccgtggt catgcaaggc gcggcaggga taggcaagtc      840

catgctggca cacaaggtga tgctggactg ggcggacggg aagctcttcc aaggcagatt      900

tgattatctc ttctacatca actgcaggga gatgaaccag agtgccacgg aatgcagcat      960

gcaagacctc atcttcagct gctggcctga gcccagcgcg cctctccagg agctcatccg     1020

agttcccgag cgcctccttt tcatcatcga cggcttcgat gagctcaagc cttctttcca     1080

cgatcctcag ggaccctggt gcctctgctg ggaggagaaa cggcccacgg agctgcttct     1140

taacagctta attcggaaga agctgctccc tgagctatct ttgctcatca ccacacggcc     1200

cacggctttg gagaagctcc accgtctgct ggagcacccc aggcatgtgg agatcctggg     1260

cttctctgag gcagaaagga aggaatactt ctacaagtat ttccacaatg cagagcaggc     1320

gggccaagtc ttcaattacg tgagggacaa cgagcctctc ttcaccatgt gcttcgtccc     1380

cctggtgtgc tgggtggtgt gtacctgcct ccagcagcag ctggagggtg gggggctgtt     1440

gagacagacg tccaggacca ccactgcagt gtacatgctc tacctgctga gtctgatgca     1500

acccaagccg ggggccccgc gcctccagcc cccacccaac cagagagggt tgtgctcctt     1560

ggcggcagat gggctctgga atcagaaaat cctatttgag gagcaggacc tccggaagca     1620

cggcctagac ggggaagacg tctctgcctt cctcaacatg aacatcttcc agaaggacat     1680

caactgtgag aggtactaca gcttcatcca cttgagtttc caggaattct ttgcagctat     1740

gtactatatc ctggacgagg gggagggcgg ggcaggccca gaccaggacg tgaccaggct     1800

gttgaccgag tacgcgtttt ctgaaaggag cttcctggca ctcaccagcc gcttcctgtt     1860

tggactcctg aacgaggaga ccaggagcca cctggagaag agtctctgct ggaaggtctc     1920

gccgcacatc aagatggacc tgttgcagtg gatccaaagc aaagctcaga gcgacggctc     1980

caccctgcag cagggctcct tggagttctt cagctgcttg tacgagatcc aggaggagga     2040

gtttatccag caggccctga gccacttcca ggtgatcgtg gtcagcaaca ttgcctccaa     2100

gatggagcac atggtctcct cgttctgtct gaagcgctgc aggagcgccc aggtgctgca     2160

cttgtatggc gccacctaca gcgcggacgg ggaagaccgc gcgaggtgct ccgcaggagc     2220

gcacacgctg ttggtgcagc taccagagag gaccgttctg ctggacgcct acagtgaaca     2280

tctggcagcg gccctgtgca ccaatccaaa cctgatagag ctgtctctgt accgaaatgc     2340

cctgggcagc cggggggtga agctgctctg tcaaggactc agacacccca actgcaaact     2400

tcagaacctg aggctgaaga ggtgccgcat ctccagctca gcctgcgagg acctctctgc     2460

agctctcata gccaataaga atttgacaag gatggatctc agtggcaacg gcgttggatt     2520

cccaggcatg atgctgcttt gcgagggcct gcggcatccc cagtgcaggc tgcagatgat     2580

tcagttgagg aagtgtcagc tggagtccgg ggcttgtcag gagatggctt ctgtgctcgg     2640

caccaaccca catctggttg agttggacct gacaggaaat gcactggagg atttgggcct     2700

gaggttacta tgccagggac tgaggcaccc agtctgcaga ctacggactt tgtggctgaa     2760

gatctgccgc ctcactgctg ctgcctgtga cgagctggcc tcaactctca gtgtgaacca     2820

gagcctgaga gagctggacc tgagcctgaa tgagctgggg gacctcgggg tgctgctgct     2880

gtgtgagggc ctcaggcatc ccacgtgcaa gctccagacc ctgcggttgg gcatctgccg     2940

gctgggctct gccgcctgtg agggtctttc tgtggtgctc caggccaacc acaacctccg     3000

ggagctggac ttgagtttca acgacctggg agactggggc ctgtggttgc tggctgaggg     3060

gctgcaacat cccgcctgca gactccagaa actgtggctg gatagctgtg gcctcacagc     3120

caaggcttgt gagaatcttt acttcaccct ggggatcaac cagaccttga ccgaccttta     3180

cctgaccaac aacgccctag gggacacagg tgtccgactg ctttgcaagc ggctgagcca     3240

tcctggctgc aaactccgag tcctctggtt atttgggatg gacctgaata aaatgaccca     3300

cagtaggttg gcagcgcttc gagtaacaaa accttatttg gacattggct gctgaatggt     3360

cctatctgct ggctctcccc tgagatctgg acagaggaag atgggagggt gctcatcacc     3420

cccccagcat aatgatcagc ctccttccta gagacagact catgcagatt gagatcaaaa     3480

gtccctctgc ttgggatcaa attaatgttt gacagagctg gccaggcgtg gtggctcatg     3540

tatgtaatcc tagcacttcg agaggccgag gcaggtggat cacgaggtca ggagtttgag     3600

attagcctgg ccaagatggt gaaaccctgt ctctactaaa aataaaaaaa aattagccag     3660

gcatggtggc gggcacctgt agtcccagct actcaggagg ctgaggcagg agaatcgctt     3720

gaacccggga ggtggaggtt gcagtgagcc gagatcgcgc cactgcactc cagcctgggc     3780

gacagagtgg gactccatct c                                               3801


<210> 949
<211> 4116
<212> DNA
<213> Homo sapiens

<400> 949
ctggtctgcg gctgagatac acagagcgac agagacattt attgttattt gttttttggt       60

ggcaaaaagg gaaaatggcg aacgactccc ctgcaaaaag tctggtggac atcgacctct      120

cctccctgcg ggatcctgct gggatttttg agctggtgga agtggttgga aatggcacct      180

atggacaagt ctataagggt cgacatgtta aaacgggtca gttggcagcc atcaaagtta      240

tggatgtcac tgaggatgaa gaggaagaaa tcaaactgga gataaatatg ctaaagaaat      300

actctcatca cagaaacatt gcaacatatt atggtgcttt catcaaaaag agccctccag      360

gacatgatga ccaactctgg cttgttatgg agttctgtgg ggctgggtcc attacagacc      420

ttgtgaagaa caccaaaggg aacacactca aagaagactg gatcgcttac atctccagag      480

aaatcctgag gggactggca catcttcaca ttcatcatgt gattcaccgg gatatcaagg      540

gccagaatgt gttgctgact gagaatgcag aggtgaaact tgttgacttt ggtgtgagtg      600

ctcagctgga caggactgtg gggcggagaa atacgttcat aggcactccc tactggatgg      660

ctcctgaggt catcgcctgt gatgagaacc cagatgccac ctatgattac agaagtgatc      720

tttggtcttg tggcattaca gccattgaga tggcagaagg tgctccccct ctctgtgaca      780

tgcatccaat gagagcactg tttctcattc ccagaaaccc tcctccccgg ctgaagtcaa      840

aaaaatggtc gaagaagttt tttagtttta tagaagggtg cctggtgaag aattacatgc      900

agcggccctc tacagagcag cttttgaaac atccttttat aagggatcag ccaaatgaaa      960

ggcaagttag aatccagctt aaggatcata tagatcgtac caggaagaag agaggcgaga     1020

aagatgaaac tgagtatgag tacagtggga gtgaggaaga agaggaggaa gtgcctgaac     1080

aggaaggaga gccaagttcc attgtgaacg tgcctggtga gtctactctt cgccgagatt     1140

tcctgagact gcagcaggag aacaaggaac gttccgaggc tcttcggaga caacagttac     1200

tacaggagca acagctccgg gagcaggaag aatataaaag gcaactgctg gcagagagac     1260

agaagcggat tgagcagcag aaagaacaga ggcgacggct agaagagcaa caaaggagag     1320

agcgggaagc tagaaggcag caggaacgtg aacagcgaag gagagaacaa gaagaaaaga     1380

ggcgtctaga ggagttggag agaaggcgca aagaagaaga ggagaggaga cgggcagaag     1440

aagaaaagag gagagttgaa agagaacagg agtatatcag gcgacagcta gaagaggagc     1500

agcggcactt ggaagtcctt cagcagcagc tgctccagga gcaggccatg ttactggagt     1560

gccgatggcg ggagatggag gagcaccggc aggcagagag gctccagagg cagttgcaac     1620

aagaacaagc atatctcctg tctctacagc atgaccatag gaggccgcac ccgcagcact     1680

cgcagcagcc gccaccaccg cagcaggaaa ggagcaagcc aagcttccat gctcccgagc     1740

ccaaagccca ctacgagcct gctgaccgag cgcgagaggt ggaagataga tttaggaaaa     1800

ctaaccacag ctcccctgaa gcccagtcta agcagacagg cagagtattg gagccaccag     1860

tgccttcccg atcagagtct ttttccaatg gcaactccga gtctgtgcat cccgccctgc     1920

agagaccagc ggagccacag gtacagtggt cccacctggc atctctcaag aacaatgttt     1980

cccctgtctc gcgatcccat tccttcagtg acccttctcc caaatttgca caccaccatc     2040

ttcgttctca ggacccatgt ccaccttccc gcagtgaggt gctcagtcag agctctgact     2100

ctaagtcaga ggcgcctgac cctacccaaa aggcttggtc tagatcagac agtgacgagg     2160

tgcctccaag ggttcctgtg agaacaacat ctcgctcccc tgttctgtcc cgtcgagatt     2220

ccccactgca gggcagtggg cagcagaata gccaggcagg acagagaaac tccaccagca     2280

gtattgagcc caggcttctg tgggagagag tggagaagct ggtgcccaga cctggcagtg     2340

gcagctcctc agggtccagc aactcaggat cccagcccgg gtctcaccct gggtctcaga     2400

gtggctccgg ggaacgcttc agagtgagat catcatccaa gtctgaaggc tctccatctc     2460

agcgcctgga aaatgcagtg aaaaaacctg aagataaaaa ggaagttttc agacccctca     2520

agcctgctgt aaggattgat ctgaccgcac tggccaaaga gcttcgagca gtggaagatg     2580

tacggccacc tcacaaagta acggactact cctcatccag tgaggagtcg gggacgacgg     2640

atgaggagga cgacgatgtg gagcaggaag gggctgacga gtccacctca ggaccagagg     2700

acaccagagc agcgtcatct ctgaatttga gcaatggtga aacggaatct gtgaaaacca     2760

tgattgtcca tgatgatgta gaaagtgagc cggccatgac cccatccaag gagggcactc     2820

taatcgtccg ccagactcag tccgctagta gcacactcca gaaacacaaa tcttcctcct     2880

cctttacacc ttttatagac cccagattac tacagatttc tccatctagc ggaacaacag     2940

tgacatctgt ggtgggattt tcctgtgatg ggatgagacc agaagccata aggcaagatc     3000

ctacccggaa aggctcagtg gtcaatgtga atcctaccaa cactaggcca cagagtgaca     3060

ccccggagat tcgtaaatac aagaagaggt ttaactctga gattctgtgt gctgccttat     3120

ggggagtgaa tttgctagtg ggtacagaga gtggcctgat gctgctggac agaagtggcc     3180

aagggaaggt ctatcctctt atcaaccgaa gacgatttca acaaatggac gtacttgagg     3240

gcttgaatgt cttggtgaca atatctggca aaaaggataa gttacgtgtc tactatttgt     3300

cctggttaag aaataaaata cttcacaatg atccagaagt tgagaagaag cagggatgga     3360

caaccgtagg ggatttggaa ggatgtgtac attataaagt tgtaaaatat gaaagaatca     3420

aatttctggt gattgctttg aagagttctg tggaagtcta tgcgtgggca ccaaagccat     3480

atcacaaatt tatggccttt aagtcatttg gagaattggt acataagcca ttactggtgg     3540

atctcactgt tgaggaaggc cagaggttga aagtgatcta tggatcctgt gctggattcc     3600

atgctgttga tgtggattca ggatcagtct atgacattta tctaccaaca catatccagt     3660

gtagcatcaa accccatgca atcatcatcc tccccaatac agatggaatg gagcttctgg     3720

tgtgctatga agatgagggg gtttatgtaa acacatatgg aaggatcacc aaggatgtag     3780

ttctacagtg gggagagatg cctacatcag tagcatatat tcgatccaat cagacaatgg     3840

gctggggaga gaaggccata gagatccgat ctgtggaaac tggtcacttg gatggtgtgt     3900

tcatgcacaa aagggctcaa agactaaaat tcttgtgtga acgcaatgac aaggtgttct     3960

ttgcctctgt tcggtctggt ggcagcagtc aggtttattt catgacctta ggcaggactt     4020

ctcttctgag ctggtagaag cagtgtgatc cagggattac tggcctccag agtcttcaag     4080

atcctgagaa cttggaattc cttgtaactg gagctc                               4116


<210> 950
<211> 1622
<212> DNA
<213> Homo sapiens

<400> 950
gaggcccgag gggcggccca ggactcgagg atgtacacgc tgctgtcggg cttgtacaag       60

tacatgtttc agaaggacga gtactgcatc ctgatcctgg gcctggacaa tgctgggaag      120

acgaccttcc tggagcagtc gaaaacccga tttaacaaga actacaaggg gatgagtcta      180

tccaaaatca ccaccaccgt gggcctaaac atcggcactg tggatgtggg aaaggctcgg      240

ctcatgttct gggacttagg agggcaggaa gagctgcagt ctttgtggga caagtattat      300

gcggagtgtc acggcgtcat ctacgtcatt gactccaccg acgaggagag gctggctgag      360

tccaagcagg cgtttgagaa ggtggtgacc agcgaggcgc tgtgcggtgt ccccgtcttg      420

gtgctggcca acaagcagga tgtggagacg tgcctctcaa tccctgacat caagacggcc      480

ttcagcgact gcaccagcaa gatcggcagg cgagattgcc tgacccaggc ctgctcggcc      540

ctcacaggca aaggggtgcg cgagggcatc gagtggatgg tgaagtgtgt cgtgcggaat      600

gtgcaccggc cgccgcggca gagggacatc acgtaggcgc agccgcgctg ccgtcgggac      660

ggctggtccc ctggtgctgg aggagtggcc tcctgttggc tcccatgctg ctgatctggg      720

gggtgggttt gctttgcttt ggggttcttc tatttacttt gttttctcga agacaaactt      780

tcctctatgt ctggaaaagc gtaggcatcc ggaggctttg gaggggagtc tggcagcccg      840

gctggcccag gccctgcagc ggcagccttt ccacagggcg cagcggcggc ctttcgaggc      900

cctttctggg gggtctgagg gagacctggt tgggaattgg ggctccagtg ctcaggctgg      960

cttgggctgc atgaggacag ccctgtggga ccctcgggag accccgtggc tgtctccgcc     1020

ccatcgagga ggaggcccgt cagccatggc tgccatctgg cttctgccct gtgaccccgt     1080

gaccccgtga ccccgaagtg gtctggggct gatcttgcct tgaggaagac ccaggccatg     1140

ttcccaaagg ccagcggggg ccctggattg tgatgcagcc tcgggacagg gctgaggcct     1200

gcgggggaag acctataccc cacgcctggg cctggcttca cctcacccta atcccccggg     1260

agggagctga ctgatgcaaa aagctgaggg ggcctgctgg gagtggctgt ttttatgccc     1320

cagccccgca agttggggag tgtttgtggg ggtccagagc cctcccccag ccaggagaga     1380

acctcccgga ggggttctct gtggggccct gtgtcccctg ctcgggagta aggctggtcc     1440

tggggtcctc cctgcacgga ccccactggg cctgccgagt gctgtgttct tcctcagtct     1500

ggctgtgggc aggagcggcc tgcccagtgt cacccagggt gagtgcaaaa taaagacggc     1560

gagtgtggct ctgtccatcc cttccctcct ggagggtgga ggctcctggc tgttggacac     1620

gg                                                                    1622


<210> 951
<211> 2917
<212> DNA
<213> Homo sapiens

<400> 951
ggcggcgggg ctgggcggtg cttccgcctg cgcgaggccg cgccgggccg cttggaggcg       60

cccggtgcag tcgggaaccc gcgctaggtt tcgccggccg cgcggccaga tgaggggggc      120

gatggagctg gagcctgagc tgctgttgca ggaggcccgc gagaacgtgg aggcagcgca      180

gagctaccgg cgggagctgg gtcaccggct tgaggggctg cgtgaggcgc ggaggcagat      240

caaagaaagt gcatcacaga caagggatgt tctcaaacag cattttaatg atttaaaggg      300

aacccttgga aagctcctgg atgagcgatt ggtgaccctt ttgcaagagg tggacaccat      360

tgaacaggag accattaaac cactagatga ctgccagaag ctcatagaac acggagtcaa      420

cactgcagag gacttagtcc gagaaggtga aatcgccatg cttggtggtg tgggagaaga      480

gaatgagaaa ctgtggagct ttaccaaaaa ggcctcgcac attcagttgg acagcttacc      540

agaagtacct ttactggttg atgtgccttg tttatctgct cagttggatg actcaattct      600

taacatagtg aaagaccaca tttttaagca tggaacagta gcatctcgcc caccagtaca      660

gatagaagaa ctaatagaga aacctggagg catcattgta cgatggtgta aggtggatga      720

tgactttaca gcccaagatt acaggctcca gtttcgtaaa tgtacttcaa atcattttga      780

ggatgtatat gtaggttctg aaactgaatt catagtattg cacatagacc ccaacgttga      840

ttaccagttc agagtctgcg cccgaggaga tggccgacag gagtggagtc cttggagtgt      900

cccccagata ggtcattcca cattggtgcc tcatgagtgg acagctggtt ttgaggggta      960

cagtctgagc agtcgaagaa atatagcact tcggaacgat tctgaatcat cgggtgttct     1020

ctactccaga gctccgactt atttctgtgg gcagacatta acattcagag ttgaaactgt     1080

gggacagcca gacagaagag atagcatagg agtgtgtgca gaaaaacagg atggatatga     1140

ctctctgcag cgggatcaag ctgtgtgcat tagtacaaat ggtgcagttt ttgtcaatgg     1200

aaaagaaatg acaaatcagt tacccgcagt tacttctggg tccactgtca cgtttgacat     1260

tgaagccgtg actctaggaa ccaccagtaa taatgaaggt ggacacttca agcttcgagt     1320

aactataagt tcaaataata gagaagtggt ttttgactgg ttacttgatc agtcttgtgg     1380

ttctctttac tttggatgct catttttcta tcctggatgg aaagtgttag tgttttagat     1440

gtttgggtgc ttggctttgg ttttcagggt ctaacgtagc tgtcctcagc ccagcgtagt     1500

tgtaattgct ttaaaaaaaa agttgaattc atctctaact taggccattg gaaagtgttt     1560

actggattca ttttgtaata ttttagcaaa aagagacttc aatgttgtgg acaaaatcat     1620

acaattcagt caattttatt tttagcatac tgttaaatat cacatcacaa taaaaatcaa     1680

attggcatta aaagtataga agatatagga agttctatac ccttccactg tacttctcaa     1740

agttggttat tagaccagga aaacttaatg taatattatt tttaaaatca tcttaaagga     1800

tccaagtcca tgtaactctt tagaacaaga ggaataggtc agatagaaga agctgtgtaa     1860

tgtattaata catccgttca tgtgctgtcc acatgaatgt gttgactgtg ctctccatgt     1920

tcaggtattt gtaagcagtg ttgactttta tcccctcttc agtaatcttt aagtccccaa     1980

aacattataa ctttttcttt ttttgttgag acggagtctc actcttgtca ctcaggctgg     2040

agtgcagtgg tgtgatctca gttcactgca acctctgcct cccacgttca agcgatcctc     2100

ctgcctcagg ctcctgagta gctgggatta caggcgtcgg ccaccacacc tggctaattt     2160

ttgtattttt agtagagaca gggtttcacc atgttggcca ggctggtctt gaactcctga     2220

cctcaggtgt tccacccacc tcagccttcc aaagtgctag gattacaggt gtgagccact     2280

gcagtggacc aatttttgta tttttttaaa tgcttgacca agtgtctaaa ataggcaagt     2340

agtacctttt gttctttcat tgcaatttga tacagtatag gctacagtat ttttacaggg     2400

taaaactagt tatggcagta gtatgcacag cagtgttagc catttcatat gtatgtaata     2460

tgcacgtgtg tatccaatct gcctgtgaca tgcattttac tctttgcaga gaatgagctg     2520

cagtccagtt taatgtcagt ttaataagtg gtctcttttt agcagagcaa aaaaatatag     2580

cgtaaatact tatttttttt aaaaacttac ttaaatttgt gtgtaaaata tttatttgaa     2640

ggactttaat atgtaaaaat aattgtcttc tatgccaccc tacagatttt attttaatgt     2700

gaattatttt tttcatttca tttttaccag tatagtaaaa aagtagaaaa gcaagtatga     2760

tatttttgta agataattta tttggggatt catgttccct gttagacaat catgaccttt     2820

tctacttgtc tttttatata taagtagtag atttccactt gtttagggat taagaagatg     2880

ttctagaatg tagatacctt gtccagccat aggaatc                              2917


<210> 952
<211> 2804
<212> DNA
<213> Homo sapiens

<400> 952
gaaatggggc ggggagagag tgacaccacc cctctgcctg tggctggatt ggtgggcgtg       60

gcgggggcgt ggcgatgcct gccctccgga caaggcgggg ttggtggcca gggcgaccgc      120

ggggcgggcc agcgccgggg gtcgtggccg ggacacgtgg tacggaaccg gcgccgcgct      180

tgctgctggt aacagggcct tgcctagtgg gccttccttc ccaggtcgcc cctcagtctc      240

cactagagac aggactgacc agttgctctt ccttccaaga accttcgaga tctgcggtct      300

ggggtctggt tgaaagatgg cggccctcac taccctgttt aagtacatag atgaaaatca      360

ggatcgctac attaagaaac tcgcaaaatg ggtggctatc cagagtgtgt ctgcgtggcc      420

ggagaagaga ggcgaaatca ggaggatgat ggaagttgct gctgcagatg ttaagcagtt      480

ggggggctct gtggaactgg tggatatcgg aaaacaaaag ctccctgatg gctcggagat      540

cccgctccct cctattctgc tcggcaggct gggctccgac ccacagaaga agaccgtgtg      600

catttacggg cacctggatg tgcagcctgc agccctggag gacggctggg acagcgagcc      660

cttcaccctg gtggagcgag acggcaagct gtatgggaga ggttcgactg atgataaggg      720

cccggtggcc ggctggataa acgccctgga agcgtatcag aaaacaggcc aggagattcc      780

tgtcaacgtc cgattctgcc tcgaaggcat ggaggagtca ggctctgagg gcctagacga      840

gctgattttt gcccggaaag acacattctt taaggatgtg gactatgtct gcatttctga      900

caattactgg ctgggaaaga agaagccctg catcacctac ggcctcaggg gcatttgcta      960

ctttttcatc gaggtggagt gcagcaacaa agacctccat tctggggtgt acgggggctc     1020

ggtgcatgag gccatgactg atctcatttt gctgatgggc tctttggtgg acaagagggg     1080

gaacatcctg atccccggca ttaacgaggc cgtggccgcc gtcacggaag aggagcacaa     1140

gctgtacgac gacatcgact ttgacataga ggagtttgcc aaggatgtgg gggcgcagat     1200

cctcctgcac agccacaaga aagacatcct catgcaccga tggcggtacc cgtctctgtc     1260

cctccatggc atcgaaggcg ccttctctgg gtctggggcc aagaccgtga ttcccaggaa     1320

ggtggttggc aagttctcca tcaggctcgt gccgaacatg actcctgaag tcgtcggcga     1380

gcaggtcaca agctacctaa ctaagaagtt tgctgaacta cgcagcccca atgagttcaa     1440

ggtgtacatg ggccacggtg ggaagccctg ggtctccgac ttcagtcacc ctcattacct     1500

ggctgggaga agagccatga agacagtttt tggtgttgag ccagacttga ccagggaagg     1560

cggcagtatt cccgtgacct tgacctttca ggaggccacg ggcaagaacg tcatgctgct     1620

gcctgtgggg tcagcggatg acggagccca ctcccagaat gaaaagctca acaggtataa     1680

ctacatagag ggaaccaaga tgctggccgc gtacctgtat gaggtctccc agctgaagga     1740

ctaggccaag ccctctgtgt gccatctcca atgagaagga atcctgccct cacctcaccc     1800

ttttccaact tgcccaggga agtggaggtt ccctctttcc tttccctctt gtcaggtcat     1860

ccatgacttt agagaacaga cacaagtgta tccagctgtc cacgggtgga gctacccgtt     1920

gggcttatga gtgacctgga gtgacagctg agtcaccctg ggtaagttct cagagtggtc     1980

aggatggctt gacctgcaga agatacccaa ggtccaaaag cacaaggtct gcggaaagtt     2040

ctggttgtcg gccgggcacc acggctcaca cctataatcg agcactttgg gaggccaaga     2100

caggaggatc acttgaggcc aggagtctga gacaagccta ggcaacaaaa caagactctg     2160

tctctacaaa aagtttaaga aatgagccag acatggtggt gtatgcctgt agtcccagcc     2220

actcagaagg ctgaggcagg aggatcgctt gagaccaaga gtttgagcct gcggtgagct     2280

gtgaatgcac cacggcactc aagcctgggc aatgtagcaa gatcctgtct ctacaagaaa     2340

ttttttaaaa atgagccaag tgtggtggtg catgcctgta gttccagcta ctcaggacac     2400

tgacgtagga gggttgcttg agactgagag ttggaggctg cgatgagcca tgaatgcccc     2460

actgcactcc agcctgggcg acagaacgag accccatctc aaaaaaaata agttctggtt     2520

gtcattgaat tgggataaac agagagcttg atgctttctg ccttctgtct caggtgatgc     2580

attgcacatt tgggatattt ggaaaggaaa tgaggaaaga aattagggcc tcctctgatc     2640

tctcgctatc tgcgggtcct gtccttttct caagaccttc accattactg gcattttcct     2700

gtcttctctt tagtatgatc cctcaaaacc tcactaactg gaaggatgat tttgtctcag     2760

tttgtactcc taaataaaaa gtaaacatga cacctctaaa agaa                      2804


<210> 953
<211> 6330
<212> DNA
<213> Homo sapiens

<400> 953
atggctgagg tcaccgtccc aagggtgtat gtcgtgtttg gcatccattg catcatggcg       60

aaggcatctt cagatgtgca ggtttcaggc tttcatcgga aaatccagca cgttaaaaat      120

gaactttgcc acatgttgag cttggaggag gtggccccag tgctgcagca gacattactt      180

caggacaacc tcttgggcag ggtacatttt gaccaattta aagaagcatt aatactcatc      240

ttgtccagaa ctctgtcaaa tgaagaacac tttcaagaac cagactgctc actagaagct      300

cagcccaaat atgttagagg tgggaagcgt tacggacgaa ggtccttgcc cgagttccaa      360

gagtccgtgg aggagtttcc tgaagtgacg gtgattgagc cactggatga agaagcgcgg      420

ccttcacaca tcccagccgg tgactgcagt gagcactgga agacgcaacg cagtgaggag      480

tatgaagcgg aaggccagtt aaggttttgg aacccagatg acttgaatgc ttcacagagt      540

ggatcttccc ctccccaaga ctggatagaa gagaaactgc aagaagtttg tgaagatttg      600

gggatcaccc gtgatggtca cctgaaccgg aagaagctgg tctccatctg tgagcagtat      660

ggtttacaga atgtggatgg agagatgctc gaggaagtat tccataatct tgatcctgac      720

ggtacaatga gtgtagaaga ttttttctat ggtttgttta aaaatggaaa atctcttaca      780

ccatcagcat ctactccata tagacaacta aaaaggcacc tttccatgca gtctttcgat      840

gagagtggac gacgtaccac aacctcatca gcaatgacaa gtaccattgg ctttcgggtc      900

ttctcctgcc tggatgatgg gatgggccat gcatctgtgg agagaatact ggacacctgg      960

caggaagagg gcattgagaa cagccaggag atcctgaagg ccttggattt cagcctcgat     1020

ggaaacatca atttgacaga attaacactg gcccttgaaa atgaactttt ggttaccaag     1080

aacagcattc accaggcggc tctggccagc tttaaggctg aaatccggca tttgttggaa     1140

cgagttgatc aggtggtcag agaaaaagag aagctacggt cagatctgga caaggccgag     1200

aagctcaagt ctttaatggc ctcggaggtg gatgatcacc atgcggccat agagcggcgg     1260

aatgagtaca acctcaggaa actggatgaa gagtacaagg agcgaatagc agccttaaaa     1320

aatgaactcc gaaaagagag agagcagatc ctgcagcagg caggcaagca gcgtttagaa     1380

cttgaacagg aaattgaaaa ggcaaaaaca gaagagaact atatccggga ccgccttgcc     1440

ctctctttaa aggaaaacag tcgtctggaa aatgagcttc tagaaaatgc agagaagttg     1500

gcagaatatg agaatctgac aaacaaactt cagagaaatt tggaaaatgt gttagcagaa     1560

aagtttggtg acctcgatcc tagcagtgct gagttcttcc tgcaagaaga gagactgaca     1620

cagatgagaa atgaatatga gcggcagtgc agggtactac aagaccaagt agatgaactc     1680

cagtctgagc tggaagaata tcgtgcacaa ggcagagtgc tcaggcttcc gttgaagaac     1740

tcaccgtcag aagaagttga ggctaacagc ggtggcattg agcccgaaca cgggctcggt     1800

tctgaagaat gcaatccatt gaatatgagc attgaggcag agctggtcat tgaacagatg     1860

aaagaacaac atcacaggga catatgttgc ctcagactgg agctcgaaga taaagtgcgc     1920

cattatgaaa agcagctgga cgaaaccgtg gtcagctgca agaaggcaca ggagaacatg     1980

aagcaaaggc atgagaacga aacgcacacc ttagaaaaac aaataagtga ccttaaaaat     2040

gaaattgctg aacttcaggg gcaagcagca gtgctcaagg aggcacatca tgaggccact     2100

tgcaggcatg aggaggagaa aaaacaactg caagtgaagc ttgaggagga aaagactcac     2160

ctgcaggaga agctgaggct gcaacatgag atggagctca aggctagact gacacaggct     2220

caagcaagct ttgagcggga gagggaaggc cttcagagta gcgcctggac agaagagaag     2280

gtgagaggct tgactcagga actagagcag tttcaccagg agcagctgac aagcctggtg     2340

gagaaacaca ctcttgagaa agaggagtta agaaaagagc tcttggaaaa gcaccaaagg     2400

gagcttcagg agggaaggga aaaaatggaa acagagtgta atagaagaac ctctcaaata     2460

gaagcccagt ttcagtctga ttgtcagaaa gtcactgaga ggtgtgaaag cgctctgcaa     2520

agcctggagg ggcgctaccg ccaagagctg aaggacctcc aggaacagca gcgtgaggag     2580

aaatcccagt gggaatttga gaaggacgag ctcacccagg agtgtgcgga agcccaggag     2640

ctgctgaaag agactcttaa gagagagaaa acaacttctc tggtcctgac ccaggagaga     2700

gagatgctgg agaaaacata caaagaacat ttgaacagca tggtcgtcga gagacagcag     2760

ctactccaag acctggaaga cctaagaaat gtatctgaaa cccagcaaag cctgctgtct     2820

gaccagatac ttgagctgaa gagcagtcac aaaagggaac tgagggagcg tgaggaggtc     2880

ctgtgccagg caggggcttc ggagcagctg gccagccagc ggctggaaag actagaaatg     2940

gaacatgacc aggaaaggca ggaaatgatg tccaagcttc tagccatgga gaacattcac     3000

aaagcgacct gtgagacagc agatcgagaa agagccgaga tgagcacaga aatctccaga     3060

cttcagagta aaataaagga aatgcagcag gcaacatctc ctctctcaat gcttcagagt     3120

ggttgccagg tgataggaga ggaggaggtg gaaggagatg gagccctgtc cctgcttcag     3180

caaggggagc agctgttgga agaaaatggg gacgtcctct taagcctgca gagagctcat     3240

gaacaggcag tgaaggaaaa tgtgaaaatg gctactgaaa tttctagatt gcaacagagg     3300

ctacaaaagt tagagccagg gttagtaatg tcttcttgtt tggatgagcc agctactgag     3360

ttttttggaa atactgcgga acaaacagag cagtttttac agcaaaaccg aacgaagcaa     3420

gtagaaggtg tgaccaggcg gcatgtccta agtgacctgg aagatgatga ggtccgggac     3480

ctgggaagta cagggacgag ctctgttcag agacaggaag tcaaaataga ggagtctgaa     3540

gcttcagtag agggtttttc tgagcttgaa aacagtgaag agaccaggac tgaatcctgg     3600

gagctgaaga atcagattag tcagcttcag gaacagctaa tgatgttatg tgcggactgt     3660

gatcgagctt ctgaaaagaa acaggaccta ctttttgatg tttctgtgct aaaaaagaaa     3720

ctgaagatgc ttgagagaat ccctgaggct tctcccaaat ataagctgtt gtatgaagat     3780

gtgagccgag aaaatgactg ccttcaggaa gagctgagaa tgatggagac acgctacgat     3840

gaggcactag aaaataacaa agaactcact gcagaggttt tcaggttgca ggatgagctg     3900

aagaaaatgg aggaagtcac tgaaacattc ctcagcctgg aaaagagtta cgatgaggtc     3960

aaaatagaaa atgaggggct gaatgttctg gttttgagac ttcaaggcaa gattgagaag     4020

cttcaggaaa gcgtggtcca gcggtgtgac tgctgcttat gggaagccag tttagagaac     4080

ctggaaatcg aacctgatgg aaatatactc cagctcaatc agacactgga agagtgtgtg     4140

cccagggtta ggagtgtaca tcatgtcata gaggaatgta agcaagaaaa ccagtacctt     4200

gaggggaaca cacagctctt ggaaaaagta aaagcacatg aaattgcctg gttacatgga     4260

acaattcaga cacatcaaga aaggccaaga gtacagaatc aagttatact ggaggaaaac     4320

actactctcc taggctttca agacaaacat tttcagcatc aggccaccat agcagagtta     4380

gaactggaga aaacaaagtt acaggagctg actaggaagt tgaaggagag agtcactatt     4440

ttagttaagc aaaaagatgt actttctcac ggagaaaagg aggaagagct gaaggcaatg     4500

atgcatgact tgcagatcac gtgcagtgag atgcagcaaa aagttgaact tctgagatat     4560

gaatctgaaa agcttcaaca ggaaaattct attttgagaa atgaaattac tactttaaat     4620

gaagaagata gcatttctaa cctgaaatta gggacattaa atggatctca ggaagaaatg     4680

tggcaaaaaa cggaaactgt aaaacaagaa aatgctgcag ttcagaagat ggttgaaaat     4740

ttaaagaaac agatttcaga attaaaaatc aaaaaccaac aattggattt ggaaaataca     4800

gaacttagcc aaaagaactc tcaaaaccag gaaaaactgc aagaacttaa tcaacgtcta     4860

acagaaatgc tatgccagaa ggaaaaagag ccaggaaaca gtgcattgga ggaacgggaa     4920

caagagaagt ttaatctgaa agaagaactg gaacgttgta aagtgcagtc ctccacttta     4980

gtgtcttctc tggaggcgga gctctctgaa gttaaaatac agacccatat tgtgcaacag     5040

gaaaaccacc ttctcaaaga tgaactggag aaaatgaaac agctgcacag atgtcccgat     5100

ctctctgact tccagcaaaa aatctctagt gttctaagct acaacgaaaa actgctgaaa     5160

gaaaaggaag ctctgagtga ggaattaaat agctgtgtcg ataagttggc aaaatcaagt     5220

cttttagagc atagaattgc gacgatgaag caggaacaga aatcctggga acatcagagt     5280

gcgagcttaa agtcacagct ggtggcttct caggaaaagg ttcagaattt agaagacacc     5340

gtgcagaatg taaacctgca aatgtcccgg atgaaatctg acctacgagt gactcagcag     5400

gaaaaggagg ctttaaaaca agaagtgatg tctttacata agcaacttca gaatgctggt     5460

ggcaagagct gggccccaga gatagctact catccatcag ggctccataa ccagcagaaa     5520

aggctgtcct gggacaagtt ggatcatctg atgaatgagg aacagcagct gctttggcaa     5580

gagaatgaga ggctccagac catggtacag aacaccaaag ccgaactcac gcactcccgg     5640

gagaaggtcc gtcagttgga atccaatctt cttcccaagc accaaaaaca tctaaaccca     5700

tcaggtacca tgaatcccac agagcaagaa aaattgagct taaagagaga gtgtgatcag     5760

tttcagaaag aacaatctcc tgctaacagg aaggtcagtc agatgaattc ccttgaacaa     5820

gaattagaaa caattcattt ggaaaatgaa ggcctgaaaa agaaacaagt aaaactggat     5880

gagcagctca tggagatgca gcacctgagg tccactgcga cgcctagccc gtcccctcat     5940

gcttgggatt tgcagctgct ccagcagcaa gcctgtccga tggtgcccag ggagcagttt     6000

ctgcagcttc aacgccagct gctgcaggca gaaaggataa accagcacct gcaggaggaa     6060

cttgaaaaca ggacctccga aaccaacaca ccacagggaa accaggaaca actggtaact     6120

gtcatggagg aacgaatgat agaagttgaa cagaaactga aactagtgaa aaggcttctt     6180

caagagaaag tgaatcagct caaagaacaa gtgagcctac ccggtcatct ctgttcaccc     6240

acctcacatt ccagctttaa ctccagtttt acatcccttt attgccatta actcgttaac     6300

ttatgttgtc taataaaggc aaattctatt                                      6330


<210> 954
<211> 4946
<212> DNA
<213> Homo sapiens

<400> 954
gtaaaaattt ttattaaagt accagtaaaa ctaaaagtgc ctacttttag ttttcactgt       60

attttcttca actcaggccc tccctctgtt gttacctgcc atctgacacg gaattttgtg      120

taattttcct tccaagtaaa gaagggaagt ttagccccag cctctaactg gttcccaaag      180

tttttgtctc tgaagccgca gtcacttcct ggagcgtctc tggctgggtg ttgcagtgct      240

ggctgggagg gtggggcaac aatttacaat tctgaacacg tgctttctgg gcaggtcgcc      300

cctcagtctc cactagagac aggactgacc agttgctctt ccttccaaga accttcgaga      360

tctgcggtct ggggtctggt tgaaagatgg cggccctcac taccctgttt aagtacatag      420

atgaaaatca ggatcgctac attaagaaac tcgcaaaatg ggtggctatc cagagtgtgt      480

ctgcgtggcc ggagaagaga ggcgaaatca ggaggatgat ggaagttgct gctgcagatg      540

ttaagcagtt ggggggctct gtggaactgg tggatatcgg aaaacaaaag gagattcctg      600

tcaacgtccg attctgcctc gaaggcatgg aggagtcagg ctctgagggc ctagacgagc      660

tgatttttgc ccggaaagac acattcttta aggatgtgga ctatgtctgc atttctgaca      720

attactggct gggaaagaag aagccctgca tcacctacgg cctcaggggc atttgctact      780

ttttcatcga ggtggagtgc agcaacaaag acctccattc tggggtgtac gggggctcgg      840

tgcatgaggc catgactgat ctcattttgc tgatgggctc tttggtggac aagaggggga      900

acatcctgat ccccggcatt aacgaggccg tggccgccgt cacggaagag gagcacaagc      960

tgtacgacga catcgacttt gacatagagg agtttgccaa ggatgtgggg gcgcagatcc     1020

tcctgcacag ccacaagaaa gacatcctca tgcaccgatg gcggtacccg tctctgtccc     1080

tccatggcat cgaaggcgcc ttctctgggt ctggggccaa gaccgtgatt cccaggaagg     1140

tggttggcaa gttctccatc aggctcgtgc cgaacatgac tcctgaagtc gtcggcgagc     1200

aggtcacaag ctacctaact aagaagtttg ctgaactacg cagccccaat gagttcaagg     1260

tgtacatggg ccacggtggg aagccctggg tctccgactt cagtcaccct cattacctgg     1320

ctgggagaag agccatgaag acagtttttg gtgttgagcc agacttgacc agggaaggcg     1380

gcagtattcc cgtgaccttg acctttcagg aggccacggg caagaacgtc atgctgctgc     1440

ctgtggggtc agcggatgac ggagcccact cccagaatga aaagctcaac aggtataact     1500

acatagaggg aaccaagatg ctggccgcgt acctgtatga ggtctcccag ctgaaggact     1560

aggccaagcc ctctgtgtgc catctccaat gagaaggaat cctgccctca cctcaccctt     1620

ttccaacttg cccagggaag tggaggttcc ctctttcctt tccctcttgt caggtcatcc     1680

atgactttag agaacagaca caagtgtatc cagctgtcca cgggtggagc tacccgttgg     1740

gcttatgagt gacctggagt gacagctgag tcaccctggg taagttctca gagtggtcag     1800

gatggcttga cctgcagaag atacccaagg tccaaaagca caaggtctgc ggaaagttct     1860

ggttgtcggc cgggcaccac ggctcacacc tataatcgag cactttggga ggccaagaca     1920

ggaggatcac ttgaggccag gagtctgaga caagcctagg caacaaaaca agactctgtc     1980

tctacaaaaa gtttaagaaa tgagccagac atggtggtgt atgcctgtag tcccagccac     2040

tcagaaggct gaggcaggag gatcgcttga gaccaagagt ttgagcctgc ggtgagctgt     2100

gaatgcacca cggcactcaa gcctgggcaa tgtagcaaga tcctgtctct acaagaaatt     2160

ttttaaaaat gagccaagtg tggtggtgca tgcctgtagt tccagctact caggacactg     2220

acgtaggagg gttgcttgag actgagagtt ggaggctgcg atgagccatg aatgccccac     2280

tgcactccag cctgggcgac agaacgagac cccatctcaa aaaaaataag ttctggttgt     2340

cattgaattg ggataaacag agagcttgat gctttctgcc ttctgtctca ggtgatgcat     2400

tgcacatttg ggatatttgg aaaggaaatg aggaaagaaa ttagggcctc ctctgatctc     2460

tcgctatctg cgggtcctgt ccttttctca agaccttcac cattactggc attttcctgt     2520

cttctcttta gtatgatccc tcaaaacctc actaactgga aggatgattt tgtctcagtt     2580

tgtactccta aataaaaagt aaacatgaca cctctaaaag aatcgctcca tctcagttgc     2640

tcgtcgcgtg cacaccatgc ttattgagtg gtgtctggtt ggtggtgtca gctcagggca     2700

ggggacagca ggcaggaccc ggaaaacaga acccaggtct tcccaggcga gcactccctc     2760

cctcgtccac acaagtggag gctcactcgt ggccccctgc atgttccgag aagtgtccct     2820

gtctctgctc cttaacggct gtggggccac aggaagtcca gctggcttaa acaaagaatt     2880

gattggccca cttgacataa aagaacagag taaactcaat gaaaggaaaa ggctccttga     2940

agtggttggt tccagggctg ggcagggaag atgcaagatg agtctggacc ctctcacatc     3000

ggaacgtaag gatgcgctcc tgagggcgtg gggctgcgtc caaggacaca ggagccagcc     3060

tggaagagtt tgcaggggcc caggggagca attggagtga gaaaatagca gtagtgttgg     3120

atttttacca tggaataaac aacaatccat gagtccatac taatataaat aaagtgacaa     3180

agtgggtgag aaggaccagt gcccctggat gaagaatctc tgctcatgtg ggaggaaggt     3240

gggagatcaa agctggagca cttgctgctg caggtgagac ccctgacaca ctctcaaatt     3300

ggtaggcaaa ggtttaaaga acgggatatt tgcttagctt aaaagcacct cccaagggga     3360

aaacagtaac ttcacagtgg agagacctgg caggcaccac cctcagatca aaatgaacct     3420

cagcagtaat gacacgtcca catcagcacc cccaacacca ctccctgagg aggacatgcc     3480

agttctggga acatcacact catcgtgaca aaacatcaga caaacccaaa cggatgaaat     3540

gtgaggaaaa tctgtagttg gttttacgtg gatgttaatc tcttagtttt gatcattgtg     3600

ctgtagctgc ataagaggtt agctgggtga agtgtatctg gggaccctct atggcttttg     3660

catcttttct ctaagtctcc tgtcatttca aagtaaaaac aaaaaaagaa gacaagggta     3720

gcggcttcag gtacagctgg acccagcact cagtgctatc tgggcttgtg gctccaactc     3780

aactcctcca tcagaactgt gagaaatgca ttctttcagc ttctaatcct gcaaaaagaa     3840

ctgcatggtc ttcccccaga aatcctaaga gtagctgctg gtgtctcatg catgcgagct     3900

gcatatgggc ccccgttagt caggaaccca tgctgagagg tgctatgctt tgaatgtttg     3960

gctcctccca aactcgtgtt gaaacttaat agccattgta acagtattaa gaggcagggc     4020

cttcaagagc tggtcaggcc atgagggccc tgtcctcctg actgagtgaa tgctgttatt     4080

gtaggagtgg gcttgtttgg cctcctcttg ctctctctac ccctctctga gcccttgtgt     4140

tgtgggatga cacagccaga aggcccttgc caggttccgg tccctccacc ttggacctcc     4200

cagcctcccg aacgttgagc caatacatct ctgctcattg taaattacct agtcttgggc     4260

attgtgttac agcagcaaaa agcagcctac ggcagtcacc gtgctaacac ctgcagcagc     4320

ctgcggcggt caccgtgcta acacgtgcag cagcctgtgt ggctcaggcc agtcagcttc     4380

ccctggaagc aagtgtgagg tcgtcgcctc tggaagtgct agcggagggt gatctcccgg     4440

aggaaatcag agtggtgttc tactagaagg ccgatgactc ctgggtaaag tgccaatgct     4500

cacctccatc tctgcaagct cagtccctcg tggaatttcc aggagcacaa gggcaatctc     4560

gacagctcca cgttcccagt gcccgaccca agcctggccc atgatcagat aaatgcctaa     4620

gtggggtggc atggacattt gcacacgtcc agactgcttt atgttagaag ctgagctggc     4680

atgccactag ctggttttga tgtaaacaac aattttgtaa aaccctggac tgaatgggtc     4740

tgactaacgg ctggttctgt gaacttgagc ctcagcgtcc tgtgtcagaa gagcacaaac     4800

cactttccca gagaggttat gaagacagaa atgaccctgt gacccctttg caaagtatga     4860

agaacggttc ccactcatgc atggagctgg atcttctcaa gtgggaaaca ggcgtggtaa     4920

ataaatactg ttgtttcagc tggtgt                                          4946


<210> 955
<211> 6525
<212> DNA
<213> Homo sapiens

<400> 955
ccgagccggg agccgagcgc gctgggcgcg gccgtcccgc tgccgccgcc aagcccggag       60

tgcgccagcg gccatggttc ccgcggcggc gccgggcgcc tgagccccgg gacgcaagcg      120

ctggaggcgg gctgccggct gtgcgggcgc tccggagaga ccgacagaag gtgagcactg      180

tgggctatgg gatggatgag gtggagcagg accagcatga ggcccgactc aaggagctgt      240

ttgacagttt tgacacgacg ggcacagggt ccctggggca ggaggaactc accgaccttt      300

gccacatgtt gagcttggag gaggtggccc cagtgctgca gcagacatta cttcaggaca      360

acctcttggg cagggtacat tttgaccaat ttaaagaagc attaatactc atcttgtcca      420

gaactctgtc aaatgaagaa cactttcaag aaccagactg ctcactagaa gctcagccca      480

aatatgttag aggtgggaag cgttacggac gaaggtcctt gcccgagttc caagagtccg      540

tggaggagtt tcctgaagtg acggtgattg agccactgga tgaagaagcg cggccttcac      600

acatcccagc cggtgactgc agtgagcact ggaagacgca acgcagtgag gagtatgaag      660

cggaaggcca gttaaggttt tggaacccag atgacttgaa tgcttcacag agtggatctt      720

cccctcccca agactggata gaagagaaac tgcaagaagt ttgtgaagat ttggggatca      780

cccgtgatgg tcacctgaac cggaagaagc tggtctccat ctgtgagcag tatggtttac      840

agaatgtgga tggagagatg ctcgaggaag tattccataa tcttgatcct gacggtacaa      900

tgagtgtaga agattttttc tatggtttgt ttaaaaatgg aaaatctctt acaccatcag      960

catctactcc atatagacaa ctaaaaaggc acctttccat gcagtctttc gatgagagtg     1020

gacgacgtac cacaacctca tcagcaatga caagtaccat tggctttcgg gtcttctcct     1080

gcctggatga tgggatgggc catgcatctg tggagagaat actggacacc tggcaggaag     1140

agggcattga gaacagccag gagatcctga aggccttgga tttcagcctc gatggaaaca     1200

tcaatttgac agaattaaca ctggcccttg aaaatgaact tttggttacc aagaacagca     1260

ttcaccaggc ggctctggcc agctttaagg ctgaaatccg gcatttgttg gaacgagttg     1320

atcaggtggt cagagaaaaa gagaagctac ggtcagatct ggacaaggcc gagaagctca     1380

agtctttaat ggcctcggag gtggatgatc accatgcggc catagagcgg cggaatgagt     1440

acaacctcag gaaactggat gaagagtaca aggagcgaat agcagcctta aaaaatgaac     1500

tccgaaaaga gagagagcag atcctgcagc aggcaggcaa gcagcgttta gaacttgaac     1560

aggaaattga aaaggcaaaa acagaagaga actatatccg ggaccgcctt gccctctctt     1620

taaaggaaaa cagtcgtctg gaaaatgagc ttctagaaaa tgcagagaag ttggcagaat     1680

atgagaatct gacaaacaaa cttcagagaa atttggaaaa tgtgttagca gaaaagtttg     1740

gtgacctcga tcctagcagt gctgagttct tcctgcaaga agagagactg acacagatga     1800

gaaatgaata tgagcggcag tgcagggtac tacaagacca agtagatgaa ctccagtctg     1860

agctggaaga atatcgtgca caaggcagag tgctcaggct tccgttgaag aactcaccgt     1920

cagaagaagt tgaggctaac agcggtggca ttgagcccga acacgggctc ggttctgaag     1980

aatgcaatcc attgaatatg agcattgagg cagagctggt cattgaacag atgaaagaac     2040

aacatcacag ggacatatgt tgcctcagac tggagctcga agataaagtg cgccattatg     2100

aaaagcagct ggacgaaacc gtggtcagct gcaagaaggc acaggagaac atgaagcaaa     2160

ggcatgagaa cgaaacgcac accttagaaa aacaaataag tgaccttaaa aatgaaattg     2220

ctgaacttca ggggcaagca gcagtgctca aggaggcaca tcatgaggcc acttgcaggc     2280

atgaggagga gaaaaaacaa ctgcaagtga agcttgagga ggaaaagact cacctgcagg     2340

agaagctgag gctgcaacat gagatggagc tcaaggctag actgacacag gctcaagcaa     2400

gctttgagcg ggagagggaa ggccttcaga gtagcgcctg gacagaagag aaggtgagag     2460

gcttgactca ggaactagag cagtttcacc aggagcagct gacaagcctg gtggagaaac     2520

acactcttga gaaagaggag ttaagaaaag agctcttgga aaagcaccaa agggagcttc     2580

aggagggaag ggaaaaaatg gaaacagagt gtaatagaag aacctctcaa atagaagccc     2640

agtttcagtc tgattgtcag aaagtcactg agaggtgtga aagcgctctg caaagcctgg     2700

aggggcgcta ccgccaagag ctgaaggacc tccaggaaca gcagcgtgag gagaaatccc     2760

agtgggaatt tgagaaggac gagctcaccc aggagtgtgc ggaagcccag gagctgctga     2820

aagagactct taagagagag aaaacaactt ctctggtcct gacccaggag agagagatgc     2880

tggagaaaac atacaaagaa catttgaaca gcatggtcgt cgagagacag cagctactcc     2940

aagacctgga agacctaaga aatgtatctg aaacccagca aagcctgctg tctgaccaga     3000

tacttgagct gaagagcagt cacaaaaggg aactgaggga gcgtgaggag gtcctgtgcc     3060

aggcaggggc ttcggagcag ctggccagcc agcggctgga aagactagaa atggaacatg     3120

accaggaaag gcaggaaatg atgtccaagc ttctagccat ggagaacatt cacaaagcga     3180

cctgtgagac agcagatcga gaaagagccg agatgagcac agaaatctcc agacttcaga     3240

gtaaaataaa ggaaatgcag caggcaacat ctcctctctc aatgcttcag agtggttgcc     3300

aggtgatagg agaggaggag gtggaaggag atggagccct gtccctgctt cagcaagggg     3360

agcagctgtt ggaagaaaat ggggacgtcc tcttaagcct gcagagagct catgaacagg     3420

cagtgaagga aaatgtgaaa atggctactg aaatttctag attgcaacag aggctacaaa     3480

agttagagcc agggttagta atgtcttctt gtttggatga gccagctact gagttttttg     3540

gaaatactgc ggaacaaaca gagcagtttt tacagcaaaa ccgaacgaag caagtagaag     3600

gtgtgaccag gcggcatgtc ctaagtgacc tggaagatga tgaggtccgg gacctgggaa     3660

gtacagggac gagctctgtt cagagacagg aagtcaaaat agaggagtct gaagcttcag     3720

tagagggttt ttctgagctt gaaaacagtg aagagaccag gactgaatcc tgggagctga     3780

agaatcagat tagtcagctt caggaacagc taatgatgtt atgtgcggac tgtgatcgag     3840

cttctgaaaa gaaacaggac ctactttttg atgtttctgt gctaaaaaag aaactgaaga     3900

tgcttgagag aatccctgag gcttctccca aatataagct gttgtatgaa gatgtgagcc     3960

gagaaaatga ctgccttcag gaagagctga gaatgatgga gacacgctac gatgaggcac     4020

tagaaaataa caaagaactc actgcagagg ttttcaggtt gcaggatgag ctgaagaaaa     4080

tggaggaagt cactgaaaca ttcctcagcc tggaaaagag ttacgatgag gtcaaaatag     4140

aaaatgaggg gctgaatgtt ctggttttga gacttcaagg caagattgag aagcttcagg     4200

aaagcgtggt ccagcggtgt gactgctgct tatgggaagc cagtttagag aacctggaaa     4260

tcgaacctga tggaaatata ctccagctca atcagacact ggaagagtgt gtgcccaggg     4320

ttaggagtgt acatcatgtc atagaggaat gtaagcaaga aaaccagtac cttgagggga     4380

acacacagct cttggaaaaa gtaaaagcac atgaaattgc ctggttacat ggaacaattc     4440

agacacatca agaaaggcca agagtacaga atcaagttat actggaggaa aacactactc     4500

tcctaggctt tcaagacaaa cattttcagc atcaggccac catagcagag ttagaactgg     4560

agaaaacaaa gttacaggag ctgactagga agttgaagga gagagtcact attttagtta     4620

agcaaaaaga tgtactttct cacggagaaa aggaggaaga gctgaaggca atgatgcatg     4680

acttgcagat cacgtgcagt gagatgcagc aaaaagttga acttctgaga tatgaatctg     4740

aaaagcttca acaggaaaat tctattttga gaaatgaaat tactacttta aatgaagaag     4800

atagcatttc taacctgaaa ttagggacat taaatggatc tcaggaagaa atgtggcaaa     4860

aaacggaaac tgtaaaacaa gaaaatgctg cagttcagaa gatggttgaa aatttaaaga     4920

aacagatttc agaattaaaa atcaaaaacc aacaattgga tttggaaaat acagaactta     4980

gccaaaagaa ctctcaaaac caggaaaaac tgcaagaact taatcaacgt ctaacagaaa     5040

tgctatgcca gaaggaaaaa gagccaggaa acagtgcatt ggaggaacgg gaacaagaga     5100

agtttaatct gaaagaagaa ctggaacgtt gtaaagtgca gtcctccact ttagtgtctt     5160

ctctggaggc ggagctctct gaagttaaaa tacagaccca tattgtgcaa caggaaaacc     5220

accttctcaa agatgaactg gagaaaatga aacagctgca cagatgtccc gatctctctg     5280

acttccagca aaaaatctct agtgttctaa gctacaacga aaaactgctg aaagaaaagg     5340

aagctctgag tgaggaatta aatagctgtg tcgataagtt ggcaaaatca agtcttttag     5400

agcatagaat tgcgacgatg aagcaggaac agaaatcctg ggaacatcag agtgcgagct     5460

taaagtcaca gctggtggct tctcaggaaa aggttcagaa tttagaagac accgtgcaga     5520

atgtaaacct gcaaatgtcc cggatgaaat ctgacctacg agtgactcag caggaaaagg     5580

aggctttaaa acaagaagtg atgtctttac ataagcaact tcagaatgct ggtggcaaga     5640

gctgggcccc agagatagct actcatccat cagggctcca taaccagcag aaaaggctgt     5700

cctgggacaa gttggatcat ctgatgaatg aggaacagca gctgctttgg caagagaatg     5760

agaggctcca gaccatggta cagaacacca aagccgaact cacgcactcc cgggagaagg     5820

tccgtcagtt ggaatccaat cttcttccca agcaccaaaa acatctaaac ccatcaggta     5880

ccatgaatcc cacagagcaa gaaaaattga gcttaaagag agagtgtgat cagtttcaga     5940

aagaacaatc tcctgctaac aggaaggtca gtcagatgaa ttcccttgaa caagaattag     6000

aaacaattca tttggaaaat gaaggcctga aaaagaaaca agtaaaactg gatgagcagc     6060

tcatggagaa ctcagtggtt ggaagtagca gagaagggtg cagttctctg cctgagatag     6120

tgtgtgaaga tgcagcacct gaggtccact gcgacgccta gcccgtcccc tcatgcttgg     6180

gatttgcagc tgctccagca gcaagcctgt ccgatggtgc ccagggagca gtttctgcag     6240

cttcaacgcc agctgctgca ggcagaaagg ataaaccagc acctgcagga ggaacttgaa     6300

aacaggacct ccgaaaccaa cacaccacag ggaaaccagg aacaactggt aactgtcatg     6360

gaggaacgaa tgatagaagt tgaacagaaa ctgaaactag tgaaaaggct tcttcaagag     6420

aaagtgaatc agctcaaaga acaagtgagc ctacccggtc atctctgttc acccacctca     6480

cattccagct ttaactccag ttttacatcc ctttattgcc attaa                     6525


<210> 956
<211> 3013
<212> DNA
<213> Homo sapiens

<400> 956
cggggcggcc gccgccggtg ggccgcagat gaagaggagg cggtggcagt ggtggaagaa       60

gaggcggcgg cggcgggggt agggagcctg gaaacgcgag cggggatggt aggtggtttg      120

gacccgccgg gccgccgtcg tttccagaaa gggtttgact ggaggaacct ctggagcagc      180

tgttggctgg ctcctctggc tgatggcatg ttgaggtaca tgggccagcg gcagcgaggg      240

catccaatcc agaggggtcc actctagagg ccaggccacc agcaccatgg gccagtgtgt      300

caccaagtgt aagaatccct catcgaccct gggcagcaaa aatggagacc gtgagcccag      360

caacaagtca catagcagga ggggtgcagg ccaccgtgag gagcaggtac caccctgtgg      420

caagccaggt ggagatatcc tcgtcaacgg gaccaagaag gccgaggctg ccactgaggc      480

ctgccagctg ccaacgtcct cgggagatgc tgggagggag tccaagtcca atgccgagga      540

gtcttccttg caaagattgg aagaactgtt caggcgctac aaggatgagc gggaagatgc      600

aattttggag gaaggcatgg agcgcttttg caatgacctg tgtgttgacc ccacagaatt      660

tcgagtgctg ctcttggctt ggaagttcca ggctgcaacc atgtgcaaat tcaccaggaa      720

ggagtttttt gatggctgca aagcaataag tgcagacagc attgacggaa tctgtgcacg      780

gttccctagc ctcttaacag aagccaaaca agaggataaa ttcaaggatc tctaccggtt      840

tacatttcag tttggcctgg actctgaaga agggcagcgg tcactgcatc gggaaatagc      900

cattgccctg tggaaactag tctttaccca gaacaatcct ccggtattgg accaatggct      960

aaacttccta acagagaacc cctcggggat caagggcatc tcccgggaca cttggaacat     1020

gttccttaac ttcactcagg tgattggccc tgacctcagc aactacagtg aagatgaggc     1080

ctggccaagt ctctttgaca cctttgtgga gtgggaaatg gagcgaagga aaagagaagg     1140

ggaagggaga ggtgcactca gctcagggcc tgagggcttg tgtcccgagg agcagactta     1200

gtggctctgt cccaggagca gcagcaagga tctgccagct gccctgcagc caactgagga     1260

attggaccat tttggaaatt actgaagatc cggatatttt ctactttaca cctttctctg     1320

ccttgtatct gaaagggctc taaaatgctg tatcatgttt taggcacttt cttcattttt     1380

ttggttattt tggttatttc ctttttgggg ggatctccca gaatatttga acctggttac     1440

atgttgtgta tctttttttg aagccttcag atagaataag cctgccattt cttgcacaaa     1500

tttaggtttt ttttttgttt ttttttgttt tttttttttt ttttttggta ggggagggca     1560

tagagcaggg cggggggatg ggactgttag gttgaattaa cattacaaaa tgatacagtg     1620

ccagatctca gtttcgcata ttgtttttca gggcaggtct gtactgtgtg tagtgctgtt     1680

tacatagatg aatttaggtt gtaataatta tttttaaaga tttacacaga tttgaatagc     1740

agtgttaact gttaaccaca ttgcattaat tcccaggcga tttagagctc ttggagagcc     1800

aaggccagcc aagagcattt gtagtctggt gacaaccccc ttttaagcta atttatccag     1860

aaccctgatt tccctcactt cttgctcatt ccttctttga cctattgcat ttcatgttga     1920

gtttttccat caacatgctg cacctgtcag tcaagtgagc attttttaag aacacattgt     1980

actgagaacc acttaagcat tgaatgcgga gaaagcagtg ctacctcagt tttgctggaa     2040

gtagacttct ttgatagttt tctttctttg atgaagtttc tgtattttca tgttgtaagt     2100

ggaaatactt ttttttgttt gtttgtttca tttgccttgg agccaaagtt tctgttcctg     2160

gtggtcggga aactgcctgc cggccaactg acttgaagga aaactgtggt atggagctct     2220

gcttgaattt tttttttttt aatattttta tttttttctt tgaatatcat cagcttactt     2280

gtctggcaag ggcagaagcc tggggttggc ctgaactctg ccaaacaaat atcaaagtgt     2340

atttaatagt taaatttgtg ccctttccct tcttgctgca cccatgttgt cacttaaccc     2400

ccaggagtta tttattatct ttttgttaaa gtcaggctca tttggggtaa tgtgatgact     2460

gtttaggttt acatgaccct cctctccttt ccctaccccc aaatatgtat atatacatat     2520

ataaaatatg tatatatttt acctatataa aatatatata tatacacata tatgtatcta     2580

tattcctttg tttctttgcc tgcttatact ggccataaaa gagggagctg ccttcaatgt     2640

ataaagtata agaagagtgc cagggaatgc cataatggag gcttttggat ctgaatttgg     2700

accatttcac taaagagaac atgagtttgc tcagcccttt cctcacaaga gggagggccc     2760

cggttcccca gacttctcca cgcgctggct ccataaaggc cagctttggc caggctgcca     2820

caggggcctg aggagctcac tctgggccta cctggtttca gttagagggt cctcctgtta     2880

tttttccatt taaaaagtat gtcctcagaa aactgtactg gaaggatggg tggcaggaac     2940

ttgtatagtt cagcttccaa cactttggaa cagattaaaa agggaatctt ttaaataaaa     3000

acgtataaaa ata                                                        3013


<210> 957
<211> 2531
<212> DNA
<213> Homo sapiens

<400> 957
aagttcgtca ggaaccagac cctgagattg gtggatccat gccgtacgcc actgtgcagc       60

ccgcggattg gcaggaaaag ccactcccca tccctcctgt tcgggagctg tggcagacgc      120

tctggttgtt aaggcgactc gtcccgcctt ctggggcact agtttgactt tgtgattggc      180

tactagtatc aaggaatccc ggcgtggaca gcgcgaggag aaagatggcg gcgatggcgg      240

tcgggggtgc tggtgggagc cgcgtgtcca gcgggaggga cctgaattgc gtccccgaaa      300

tagctgacac actaggggct gtggccaagc aggggtttga tttcctctgc atgcctgtct      360

tccatccgcg tttcaagagg gagttcattc aggaacctgc taagaatcgg cccggtcccc      420

agacacgatc agacctactg ctgtcaggaa gggactggaa tacgctaatt gtgggaaagc      480

tttctccatg gattcgtcca gactcaaaag tggagaagat tcgcaggaac tccgaggcgg      540

ccatgttaca ggagctgaat tttggtgcat atttgggtct tccagctttc ctgctgcccc      600

ttaatcagga agataacacc aacctggcca gagttttgac caaccacatc cacactggcc      660

atcactcttc catgttctgg atgcgggtac ccttggtggc accagaggac ctgagagatg      720

atataattga gaatgcacca actacacaca cagaggagta cagtggggag gagaaaacgt      780

ggatgtggtg gcacaacttc cggactttgt gtgactatag taagaggatt gcagtggctc      840

ttgaaattgg ggctgacctc ccatctaatc atgtcattga tcgctggctt ggggagccca      900

tcaaagcagc cattctcccc actagcattt tcctgaccaa taagaaggga tttcctgttc      960

tttctaagat gcaccagagg ctcatcttcc ggctcctcaa gttggaggtg cagttcatca     1020

tcacaggcac caaccaccac tcagagaagg agttctgctc ctacctccaa tacctggaat     1080

acttaagcca gaaccgtcct ccacctaatg cctatgaact ctttgccaag ggctatgaag     1140

actatctgca gtccccgctt cagccactga tggacaatct ggaatctcag acatatgaag     1200

tgtttgaaaa ggaccccatc aaatactctc agtaccagca ggccatctat aaatgtctgc     1260

tagaccgagt accagaagag gagaaggata ccaatgtcca ggtactgatg gtgctgggag     1320

caggacgggg acccctggtg aacgcttccc tgcgggcagc caagcaggcc gaccggcgga     1380

taaagctgta tgctgtggag aaaaacccaa atgccgtggt gacgctagag aactggcagt     1440

ttgaagaatg gggaagccaa gtgaccgtag tctcatcaga catgagggaa tgggtggctc     1500

cagagaaagc agacatcatt gtcagtgagc ttctgggctc atttgctgac aatgaattgt     1560

cgcctgagtg cctggatgga gcccagcact tcctaaaaga tgatggtgtg agcatccccg     1620

gggagtacac ttcctttctg gctcccatct cttcctccaa gctgtacaat gaggtccgag     1680

cctgtaggga gaaggaccgt gaccctgagg cccagtttga gatgccttat gtggtacggc     1740

tgcacaactt ccaccagctc tctgcacccc agccctgttt caccttcagc catcccaaca     1800

gagatcctat gattgacaac aaccgctatt gcaccttgga atttcctgtg gaggtgaaca     1860

cagtactaca tggctttgcc ggctactttg agactgtgct ttatcaggac atcactctga     1920

gtatccgtcc agagactcac tctcctggga tgttctcatg gtttcccatc ctcttcccta     1980

ttaagcagcc cataacggta cgtgaaggcc aaaccatctg tgtgcgtttc tggcgatgca     2040

gcaattccaa gaaggtgtgg tatgagtggg ctgtgacagc accagtctgt tctgctattc     2100

ataaccccac aggccgctca tataccattg gcctctagcc ctgcgtgcca agtgtccaga     2160

gccttggaag cagcttcagg ttctgctcct gtagtacaga aggtgcagta catctatggg     2220

ctgtgattcc ccttgcccat cagagaggag catttcaatc tgctttcctg ccttacatca     2280

aggtgggcaa gggattataa ttaattgcag ggctcaagcc accaatctat gaagacctca     2340

ggccaggggg tgaggaatta gtgctggatt tgaagctacg cactcagcct caagaactcc     2400

ctggaatatc cctgagaaca tggggtttga acggattttc agcctttttc tgttcttgtt     2460

ttgatggttt tgtgtaagag gaaatacaaa taaagttata gccctttact gcacgaccat     2520

gctgccccct g                                                          2531


<210> 958
<211> 1067
<212> DNA
<213> Homo sapiens

<400> 958
gtctcatggc tcctgggagc gtcaccagcg acatctcacc ctcctcgact tccacagcag       60

gatcatccag gtctcctgaa tctgaaaagc caggcccgag ccacggcggt gtcccaccag      120

gaggcccgag ccacagcagc ctcccggtgg gacgccgcca ccccccggtg ctacgcatgg      180

tgctggaggc gctgcaggct ggggagcagc gccggggcac gtcggtggca gctatcaagc      240

tctacatcct gcacaagtac ccaacagtgg acgtcctccg cttcaagtac ctgctgaagc      300

aggcgctggc cactggcatg cgccgtggcc tcctcgccag gcccctcaac tccaaagcca      360

ggggggccac tggcagcttc aaattagttc ccaagcacaa gaagaaaatc cagcccagga      420

agatggcccc cgcgacggct cccaggagag cgggtgaggc caaggggaag ggccccaaga      480

aaccaagtga ggccaaggag gaccctccca acgtgggcaa ggtgaaaaag gcagccaaga      540

ggccagcaaa ggtgcagaag cctcctccca agccaggcgc agccacagag aaggctcgca      600

agcaaggcgg cgcggccaag gacaccaggg cacagtcggg agaggctagg aaggtgcccc      660

ccaagccaga caaggccatg cgggcacctt ccagtgctgg tgggctcagc aggaaggcaa      720

aggccaaagg cagcaggagc agccaaggag atgctgaggc ctacaggaaa accaaagctg      780

agagtaagag ttcaaaaccc acggccagca aggtcaagaa tggtgctgct tccccgacca      840

aaaagaaggt ggtggccaag gccaaggccc ctaaagctgg gcaggggcca aacaccaagg      900

ctgctgctcc tgctaagggc agtgggtcca aggtggtacc tgcacatttg tccaggaaga      960

cagaggcccc caagggccct agaaaggctg ggctgcccat caaggcctca tcatccaaag     1020

tgtccagcca gagggctgaa gcttagggcc agaggcaggg gcggaga                   1067


<210> 959
<211> 2769
<212> DNA
<213> Homo sapiens

<400> 959
gcgacgccga gtttcactct ggctgccttc tcctgagagt cggagccaca gccagagccc       60

tgcccaggcc gagccggagc tgcagcccga gcgcggtggt gccctcagcc ccgtcctctt      120

gtcctcctca gcctcggtgc cttggaattt gtgtcgctga gtcagcaagc ctttcagatt      180

tgcccggttt ttgttgtttg tggtttgtat caagatggga actcaaacaa gtcattcctc      240

ctaaggagct ggtgtcttca tccagaaggg acagtttgtg ccagctctcc agagagaaaa      300

ggatctggta ctgttctgga gtggcctgta gcagacactg aaccaccagc cagctgcatt      360

tgttgtcctg gaagtcattg ccaactctgc cagtcacact ggggtcccca gagaagtcaa      420

gatctgccgg aggcgctggg caatgacccc gggactccag gccagagggg tctgaagctg      480

tttgggaaag cagcgggact ccttgggaag atggccatgg ccccaagccc ttccctggtg      540

caggtgtaca ccagccccgc ggctgtggcc gtgtgggaat ggcaggacgg gctgggcacc      600

tggcacccct acagtgccac cgtctgcagc ttcatcgagc agcagtttgt ccagcagaag      660

ggccaacgtt ttgggcttgg gagcctggcc cacagcatcc ccttgggcca ggcagacccc      720

tcgctggccc cttacattat tgacctcccc agctggaccc agttccgcca ggacaccggc      780

accatgcggg ctgtgcggag acacctgttc ccccagcact cagcccctgg ccgaggtgtc      840

gtctgggagt ggctgagcga cgatggctcc tggactgcct atgaagccag cgtctgtgac      900

tatctggagc agcaggtggc caggggcaac cagctcgtgg acttggcccc cctggggtac      960

aactacactg tcaactacac cacccacacg cagaccaaca agacttccag cttctgccgc     1020

agcgtgcggc gccaagcagg gccgccttac ccggtgacca ccatcatcgc tccgccgggc     1080

cacacaggcg tcgcctgctc ttgccaccag tgcctcagtg gcagcagaac tggccccgtg     1140

tcaggccgct accgccactc catgaccaac ctccctgcat accccgtccc ccagcacccc     1200

ccacacagga ccgcttctgt gtttgggacc caccaggcct ttgcaccgta caacaaaccc     1260

tcactctccg gggcccggtc tgcgcccagg ctgaacacca ccaacgcctg gggcgcagct     1320

cctccttccc tggggagcca gcccctctac cgctccagcc tctcccacct gggaccgcag     1380

cacctgcccc caggatcctc cacctccggt gcagtcagtg cctccctccc cagcggtccc     1440

tcaagcagcc cagggagcgt ccctgccact gtgcccatgc agatgccaaa gcccagcaga     1500

gtccagcagg cgctcgcagg catgacgagt gttctgatgt cagccattgg actccctgtg     1560

tgtcttagcc gcgcacccca gcccaccagc cctcccgcct cccgtctggc ttccaaaagt     1620

cacggctcag ttaagagatt gaggaaaatg tccgtgaaag gagcgacccc gaagccagag     1680

ccagagccag agcaggtcat aaaaaactac acggaagagc tgaaagtgcc cccagatgag     1740

gactgcatca tctgcatgga gaagctgtcc acagcgtctg gatacagcga tgtgactgac     1800

agcaaggcaa tcgggtccct agctgtgggc cacctcacca agtgcagcca tgccttccac     1860

ctgctgtgcc tcctggccat gtactgcaac ggcaataagg atggaagtct gcagtgtccc     1920

tcctgcaaaa ccatctatgg agagaagacg gggacccagc cccagggaaa gatggaggta     1980

ttacggttcc agatgtcgct ccccggccac gaggactgcg ggaccatcct catagtttac     2040

agcattcccc atggtatcca gggccctgag caccccaatc ccggaaagcc gttcactgcc     2100

agagggtttc cccgccagtg ctaccttcca gacaacgccc agggccgcaa ggtcctagag     2160

ctcctgaagg tggcctggaa gaggcggctc atcttcacag tgggcacgtc cagcaccacg     2220

ggtgagacgg acaccgtggt atggaacgag atccaccaca agacagagat ggaccgcaac     2280

attacgggcc acggctatcc cgaccccaac tacctgcaga acgtgctggc tgagctggct     2340

gcccaggggg tgaccgagga ctgcctggag cagcagtgac ctcgcacccc agcacgcccg     2400

cctctggtgg ccaccccgct gccccatggc tggctgggtg gccaggcagg aagtgcccag     2460

cccgagaggc tgggaggttt gttgagggtg tggggtgtgc cccacctgaa gccggggctc     2520

cccctgcctg cctctctctc ctcctcccct ctgggaattg ggcagccctg ggcagttgta     2580

ctcatggggg cttaggatgc agctacctca gtgcgcaggg cccgtctgtc ctctgggggc     2640

tgcttcgggc ccgcggtgct cggggcctgg tgtggggcga gtagagactt ccccagcctg     2700

gacgggcgtg ggttctgggt cagcttcttt tacctcaatt ttgtttgcaa taaatgctct     2760

atagccaaa                                                             2769


<210> 960
<211> 4686
<212> DNA
<213> Homo sapiens

<400> 960
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg       60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg      120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga      180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg      240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc      300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct      360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa      420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt      480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat      540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa      600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc      660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt      720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct      780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata      840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt      900

ttacatagaa cgtgttatga agaaatgttg aaagaaggct acagatgtcc attatgtatg      960

cactctgctt tagatatgac caggtattgg agacagctgg atgatgaagt agcacagact     1020

cctatgccat cagaatatca gaacatgact gtggatattc tctgcaatga ctgtaatgga     1080

cgatccactg ttcagtttca tatattaggc atgaaatgta agatttgtga atcctataat     1140

actgctcaag ctggaggacg tagaatttca ctggatcagc aatgacgagc ctacacagta     1200

ctggagaact tggcattttc tgatatagaa aaaggctttc cttggtatcg tgttatcatg     1260

tgtcgtcatc tatgcattag agttgatgtg ttttgtacta gtgtcacagc ataaaatcat     1320

attacaagta cgtaaggatt cagggtctct tgatagactt atcatagctc tatattgaat     1380

gaaagccact gtgcttgtgt tttgattgga aattccttta gtgtcagttt tttggaagcc     1440

aatgatgttt gccactgata cattcataga agtgtattat attttcatga agctttgctt     1500

taagtgacac tacgcgtgca gttcatttct agttcttgat agaactgcac ttaattttca     1560

gtagtagtct tgacttttta agggctgtgt tatattaagt tctcccttac tgttaaaacc     1620

taattaaata tgctttagaa ttttctaaga cagtcctctg gatcctctaa atgtgaattt     1680

tgatgtaata actgctaata aaattatatt gaaactgttt tatagaaagt tttttccaaa     1740

gttttctatg tttggctcaa ttagggcagt atcatcagtt ctataatgta aaagaaattt     1800

tctttctttt gaggtattcc ataaaagtag ttgggaaaat tattatgtaa aataataaga     1860

ctcttccaaa gccttaataa aaacatcaac attgaaaaca gtttttttta ggttgcccaa     1920

aattatttct tcaaagagtc attcattcct tcatttagca agtatttatt gagcaactgc     1980

tatgtggcag atatgtttct agatgctgta gagacaacag tgaacaataa agataaaagt     2040

ccttgtcctc acagcagtac attctattgt tcatcatatt tgatcaatgt actcattttt     2100

ctttatgcaa ggagtggatg tcttattgta aatgaataga atatttcttc cctaagcgtg     2160

tgaaaatagg ggatggatga gtgggaaggg catgggatat tcctggcaag atctctgatt     2220

tcataatact tttttgggct catgtagtgg aattaaatat acctcttact tcaggaacaa     2280

agttaacaaa tatgtttgat gatccagccg actttgacac tgttatctcc gtaatagctt     2340

taccattagg ctaggatgta aaatgtacat ttatcagttg ataagtacct attgagcacc     2400

agttgtattt ccaactttga gctatttgaa tcttctttga ataaggaagt tagcctttta     2460

actagaaagc ctaagagttc tggcacattt atttcttctt ttgttgaaat ttattcacct     2520

agataaaggc agcagtttgg gactcagatc tttattttat cccaccttct tgtcttctgt     2580

attccactct tcttatgttc tttcccttca tctgtttcct tggcctggcc agagcagcag     2640

tgctgatctt catttgggaa aggatgttcc tgggtattac caattagtat acagataagt     2700

aaagactagt tttccagatc taatactttt ttttgaagtg gttttgctct gtcatttagg     2760

ctagagtgta gtgaagtgat cgtagctcac tgcagccttg acttcctggg ctgaactgat     2820

ccttccacct cagcctcctg agtagctggg actacaggtg tgtgccacca tgcccagcta     2880

atttttaatt gttttgtaga aacaaagtcc aggctggtct tgaactcctg ggctcaagca     2940

tttctcctac ctcggccttc caagggctag gattacaggc atgagccact gtgcttggtc     3000

cagatgtatt actttttatg tttggtatta ttctgccaaa ccaatcatgt tattgttttt     3060

aatcattgaa tcattggatc tttaaatagg agtgagtata taataataag gctcttctgt     3120

tttcaacatc tgtgctgggt catgcattag cattaattac tacaatgatt ctgtggggta     3180

agtgttgtcc tcatagacaa gaaagctgag gtttagaggt taaaatgaca cattgggggt     3240

aaataacaga cactatatgt tggagttggg aatcagatcc aagtttgact ccaaacccac     3300

ttttaccaca ttgcttttga tctaaacttc tattttgcta aaatacccct cacagctagt     3360

catccatatc attgaagcgc tcatgatttg atagattaac ctttcatttt tttaggtgac     3420

tctagttaga aagtcttatt tcacaatctg attgtttctt taacttagga tccaaacatg     3480

tccaaaataa tgcagagtac atatgcaatc actcgtttat gctgtctagt catgcactta     3540

aagcaatttt caaatgtact caaagtctct aggcttcggt acccagggtt gcttcaagta     3600

tttgttcatg acacgtcaac tcgatgatta aaatccttca acacttctca ttcacaataa     3660

gaataaaatc tacatccctt accattcagt atgcaaaact taaaatacat aactttaccc     3720

ttaaatattt tttctttctc tgacttcata agtataggtt atacctctat aagaaagaag     3780

gtaaaaaact ctcaacaatc ccttctttca gagagaacta ctgttaacat tttaacagac     3840

aacttcattc ttttcctatt cttttttata atgcttacag gaatgttaaa tacttagaca     3900

gatcttaagt acactagaat tatctgtccc tgaaataagt taggttgccc tgccgcagaa     3960

tttgtatcta tagtttattt ggattatttt tgaaaaaagt aaaataacaa tacccttacg     4020

aattttttgg tgcatagcat ctcagcttct tttatcatta aagatgtatg tataaaaaaa     4080

aaatgagtgt atatcaagtt gttcatttct tagtttctgg ggtcttctta accagtacat     4140

agaactcttt atgaattaac tttagcttat gttggaagta gtagtttgtt tatagtgtca     4200

tggattttaa aatcaaactc agtttttatt tcttcactaa aacctatttt catatgatat     4260

acatgttaaa tttccctttt attttggtca tgcatcaaaa taaatttact aagtactaaa     4320

gagccaacat tattttataa gtgcctggca ataggtattc actagttgaa tagtttaatt     4380

tgaaatgaat taattttaaa tgggagttgt tcaaaactat gccacttttt cttttgtcct     4440

ttgtgttatt aaaatttaat tgataattgt gtatattata tatatggagt acaatgtgat     4500

gttttgatat atgtttacag tgtagaatga ttaaatcaat gtaataaatt tattgcctca     4560

taccattttt tgtggtaaaa aaaccactta aaatctactc ttaatatttt tgaaatgtac     4620

aatgcattat ttattatact caccattctg tgtaatagat cagtaaagtt tattcctctt     4680

gtctaa                                                                4686


<210> 961
<211> 2413
<212> DNA
<213> Homo sapiens

<400> 961
gccacaggga cagccggtgg gctcggtggg gctgcagaag gtcggggctg cactgctctc       60

ggcccccaca cggttggttg gttggcgtgg taagtgccct gatccctggt cctgagaact      120

caggctggca cagggattcc cagggcatct accaccacgc agctggagca gggctgagcc      180

caggagcatg gagatggacg cccccaggcc ccccagtctt gctgtccctg gagcagcatc      240

gaggcccggg agggctgcca tcagcagcag tgagccatca cctctgctgg ccacattgtg      300

ttttttctcc tagaactgtg gacaacggaa ggctgagccc catccattga gttcctgggg      360

ccccactgga ggggctgctg tggccagggt gcacggtcac aaatgaagac accaaggcgc      420

agagaggtga ctcagcctgc cctcagtcac ctatctgctc ctggaggtga tccccgactc      480

catgaggaag caagaggtgc ggacgggcag ggaggccggc cagggccacg gtacgggctc      540

cccagccgag caggtgaaag ccctcatgga tctgctggct gggaagggca gtcaaggctc      600

ccaggccccg caggccctgg ataggacacc ggatgccccg ctggggccct gcagcaatga      660

ctcaaggata cagaggcacc gcaaggccct gctgagcaag gtggaggcca cccgcggggg      720

cgggcacccc gccaggaccg tcgccctgga ccggctcttc ctgcctctct cccgggtgtc      780

tgtcccaccc cgggtctcca tcactatcgg ggtggccggc atgggcaaga ccaccctggt      840

gaggcacttc gtccgcctct gggcccatgg gcaggtcggc aaggacttct cgctggtgct      900

gcctctgacc ttccgggatc tcaacaccca cgagaagctg tgtgccgacc gactcatctg      960

ctcggtcttc ccgcacgtcg gggagcccag cctggcggtg gcagtcccag ccagggccct     1020

cctgatcctg gacggcttgg atgagtgcag gacgcctctg gacttctcca acaccgtggc     1080

ctgcacggac ccaaagaagg agatcccggt ggaccacctg atcaccaaca tcatccgtgg     1140

caacctcttt ccggaagttt ccatctggat cacctcccgt cccagtgcat ctggccagat     1200

cccagggggc ctggtggacc ggatgacgga gatccggggc tttaacgagg aggagatcaa     1260

ggtgtgtttg gagcagatgt tccccgagga ccaggccctt ctgggctgga tgctgagcca     1320

agtgcaggct gacagggccc tgtacctgat gtgcaccgtc ccagccttct gcaggctcac     1380

ggggatggcg ctaggccacc tgtggcgcag caggacgggg ccccaggatg cagagctgtg     1440

gcccccgagg accctgtgcg agctctactc atggtacttt aggatggccc tcagcgggga     1500

ggggcaggag aagggcaagg caagccctcg catcgagcag gtggcccatg gtggccgcaa     1560

gatggtgggg acattgggcc gtctggcctt ccatgggctg ctcaagaaga aatacgtgtt     1620

ttacgagcaa gacatgaagg cgtttggtgt agacctcgct ctgctgcagg gcgccccgtg     1680

cagctgcttc ctgcagagag aggagacgtt ggcatcgtca gtggcctact gcttcaccca     1740

cctgtccctg caggagtttg tggcagccgc gtattactat ggcgcatcca ggagggccat     1800

cttcgacctc ttcactgaga gcggcgtatc ctggcccagg ctgggcttcc tcacgcattt     1860

caggagcgca gcccagcggg ccatgcaggc agaggacggg aggctggacg tgttcctgcg     1920

cttcctctcc ggcctcttgt ctccgagggt caatgccctc ctggccggct ccctgctggc     1980

ccaaggcgag caccaggcct accggaccca ggtggctgag ctcctgcagg gctgcctgcg     2040

ccccgatgcc gcagtctgtg cacgggccat caacgtgttg cactgcctgc atgagctgca     2100

gcacaccgag ctggcccgca gcgtggagga ggccatggag agcggggccc tggccaggct     2160

gactggtccc gcgcaccgcg ctgccctggc ctacctcctg caggtgtccg acgcctgtgc     2220

ccaggaggcc aacctgtccc tgagcctcag ccagggcgtc cttcagagcc tgctgcccca     2280

gctgctctac tgccggaagc tcaggtggat accagggcag ggggcagggg ctggggaagg     2340

ggcagaggag agagcagaag ccgtcccctc cccaccacca agcttctctg tcagtctcct     2400

agggctgccg taa                                                        2413


<210> 962
<211> 3063
<212> DNA
<213> Homo sapiens

<400> 962
acgggatgta ggcggcggcg gcggtagtgg tagcggttat tcggcggccc gcggcggacc       60

atggccctgg ccctggcccg gcgtcgctgg gctttcctca cggcgtcccc gagcagcgtc      120

gcagagcggg ccgacttccg ggaaggaact gaccagcgac tgagcggcgg ccggcgcgct      180

tagcgccctg aacatgcggc agtccctgcg ggcgaccccg ggctccggac aggcggcggc      240

ggaggcggcg gctcgggagg gaaggaggcg gcggcgccgg cggaggtggc ggcggagacg      300

gccggcgccc ggcgcggagc cctagggagg cagttcagcg cggcctcggg cctcgtcgag      360

aaggatgctg tcccgaaaga aaaccaaaaa cgaagtgtcc aagccggccg aggtgcaggg      420

gaagtacgtg aagaaggaga cgtcgcctct gcttcggaat cttatgcctt cattcatccg      480

gcatggtcca acaattccaa gacgaactga tatctgtctt ccagattcaa gccctaatgc      540

cttttcaact tctggagatg tagtttcaag aaaccagagt ttccttagaa ctccaattca      600

aagaacacct catgaaataa tgagaagaga aagcaacaga ttatctgcac cttcttatct      660

tgccagaagt ctagcagatg tccctagaga gtatggttct tctcagtcat ttgtaacgga      720

agttagtttt gctgttgaaa atggagactc tggttcccga tattattatt cagacaattt      780

ttttgatggt cagagaaagc ggccacttgg agatcgtgca catgaagact acagatatta      840

tgaatacaac catgatctct tccaaagaat gccacagaat caggggaggc atgcttcagg      900

tattgggaga gttgctgcta catctttagg aaatttgact aaccatggtt ctgaagattt      960

accccttcct cctggctggt ctgtggactg gacaatgaga gggagaaaat attatataga     1020

tcataacaca aatacaactc actggagcca tcctcttgag cgagaaggac ttcctcctgg     1080

atgggaacga gttgagtcat ccgaatttgg aacctattat gtagatcaca caaataagaa     1140

ggcccaatac aggcatccct gtgctcctag tgtacctcgg tatgatcaac cacctcctgt     1200

cacataccag ccacagcaaa ctgaaagaaa tcagtccctt ctggtacctg caaatccata     1260

tcatactgca gaaattcctg actggcttca ggtttacgca cgagcccctg tgaaatatga     1320

ccacattctg aagtgggaac tcttccagct ggctgacctg gatacatacc agggaatgct     1380

aaagttgctc ttcatgaaag aattggagca gattgttaaa atgtatgaag catacagaca     1440

agcccttctt acagagttgg aaaaccgaaa gcagagacag cagtggtatg cccaacaaca     1500

tggaaaaaat ttttgagctg attttttaaa aatttaagtt ttgtaagagc tttaaaatat     1560

tttcacagat aaaaaattgc aaacaagtac tctggttaat aaatgctgct tcctttgtgg     1620

aaattataaa attctaactt tacatgtatt ttgttattag aaattttctt ttattgaatg     1680

agaaaaatta gtctatcatt ttaagagcca atatggcaaa cactttcaaa tactgtatat     1740

taggaaactg ttttggtatt cttgatggaa aaaaacgcag cggaaatgtc attatgaaca     1800

gatgttaaat aggaaattat tacttgttaa cttcttacag cagtagtacc ttctttaaaa     1860

aaaaaaaaga atctgcggta tttttttaaa aaaaaagttt accgctgtag tgtgaaatat     1920

tgtctggaaa gggatggttt aaatattacc atgatgtagt tgaaatataa aataggattt     1980

ggaaccttat tgtgataaat atttatatat gatgtatgtt tgtctcccct ctccaaagta     2040

aggaacccag ctgggcgtgg tggctcactc ctgtaatccc agcattttgg gaggccgagg     2100

tgggtggacc gcttgagtcc acgagtttaa gaccagcctg ggcaacatgg tgaagcccca     2160

tctctacaaa aaatacaaaa aaattagccg ggtatgatgg tgtgtgcctc tagtcccagc     2220

tacttgggag gctgaggtca gaggatggct tgagcccaag aggcagaggt tgcagggtca     2280

agatcgcacc acttgcactg cagcctgaga gagagagagc cagaccttgt ctcaaaaaat     2340

aaaaaataaa aaaataaaaa caaaataagg aatcctttta aagcatgttg agaaagtatt     2400

ttttggtatg aatgggtgac gggcctttta atctttcagg aatacatata agcaggaata     2460

cttagcctgt attgggaagg tgcgtgaaac tcaaagttgc taacatcatc ttccttattt     2520

tcagccagtg ctgttactgc atttagcatg gctctgacga ggcagtggag agttcctgac     2580

agcatagcat actgccttct gacagactgg gttaagctac caaaaatgac aaccagggat     2640

tcaaaaaaaa tttttggtca ttaaatcgaa tgtatattat tactttttaa ttttctaagt     2700

atttatcaca ggactttaac accatatatt tccctcccag tttttctccc cttttggttt     2760

aatagttaaa acatttttca taattagtgc tgtacatttg attgcaaaca aattggtgat     2820

acttctaaac tataactata aatctctaga attctgtgaa tttcaacatt atttgaagta     2880

gttcttcagt tatatttaca tgtgttgtaa atatgtaaat atacttttag cttaggaagt     2940

cttccagaat acaaactact cccagttaga tatcagtgag tttgaataac tgaagaaatg     3000

ttgacaatgt taagtgtttg attttatata acaagcttat taaatatatt tttgtggaaa     3060

cta                                                                   3063


<210> 963
<211> 2891
<212> DNA
<213> Homo sapiens

<400> 963
ccacccgcct ctggctcctc tccttcccac ccctgccgtg ctccggcagg aagaggtggt       60

gccagggccg ttgctaggat acgaccaaca gctgagaacg cggcgagtat ggaagctgcg      120

tcttaggagc ctgggaaagc acttcgacga gaatagtttg gtttcgtaca caggaaaatg      180

tctaatcaac aggagaagta tgaagctcag aatatagtca attcaacaga agagagtgat      240

gatgcttttg atactgtcac tattccagtt ccctcagaag agcctcaaga gtcagatcaa      300

actgaagagc atgaatctgg aatagaacaa ttcagtgaga gccatgcaat acatgttgag      360

gagcagagtg accaaagctt ttcaagcctg gaaccagaca atgaacaact catggaagag      420

gttatatcac caagacaagt ttcatatact ccgcaacatc atgaaaagca atatgcaatg      480

cagaggccaa atgatgatag tttggcattt ctggataaaa taaagtctgt aaaggaatct      540

ttgcaagaat cagtggaaga ttctctagca acagtaaaag ttgtacttat tccagtgggc      600

caggaaattg taataccttt taaggttgat accattctta aatatcttaa ggaccatttt      660

tcacacttat taggtatccc acattctgta ctgcagataa gatactcagg aaaaattctt      720

aaaaataatg agactctagt acaacatgga gttaagccac aggaaattgt acaagtggaa      780

atcttttcta caaatccaga tctgtatcca gtcagaagaa tagatggatt aactgatgtc      840

tctcaaatca taactgtcac tgtccaaact ggacttgatc aataccagca ggtacctgtt      900

gagattgtca aatctgactt tcacaaacca tttcttggtg gattcagaca taaagtaaca      960

ggagtagagt atcacaatgc tggaacacaa actgtaccta aaaggattcc cgaaagactc     1020

agtatatttt gtagggatac gcagacagtt tttcagaaaa aaaatctcca acaaactaca     1080

aatacaacat ccacacagat gactaacatt ggtgtatatg tatcaaatat gactgataaa     1140

ctggtaacac caggaaagta tttttcagca gcagaatacc atgctcaaag actaaaggcg     1200

gtgatagtga tacagactta ctacaggcaa tggcatgcta aaatcttcgt agagaattta     1260

agaagacaga aaagcttaag actggaatgg gaaacacagc aagaactaag gaagataaga     1320

gaaaaagaag aatggataaa attggactat caccggaggc ataatcctaa aacaaatgaa     1380

gattttgaat ttctttataa tgcattagaa ttctggcggc aagaagaact tacacgtatt     1440

aaccaatctt ttactggagc tgaaaggaaa gctgctctgt gtgaacttct ggaaaaagag     1500

actcagataa ttgcttccat tgggagacat agatacattg cttatatggc aaatcaggaa     1560

gcagcaatac aagctttttt ggataagtgt tcagctccaa aaatatggag aacccctaat     1620

ggcaaaacaa ttgagatgga tacgcagttc accatcagag ccagagagct gcaaaatatc     1680

tataagtgca ttatgctgaa aaatatctcc caagatgaga ggctggatgt gctgttaact     1740

cttaaacaca ctgtaaagga acatgaatgt aaactaactc aggaaattct agaattgatt     1800

gacagagagg ttgaccttat gatgagagga gtcaaacatc ataaccttga aggactcaga     1860

aaaagaattg cgacactctt ttttcattat atcaaaacac ctctgtttaa tcctgaagtt     1920

gcaaaatacc ttaaggtccc tcaagaccca ttgaaatttt ataagaagat ttacttttgc     1980

cacagttgcc agctttattt gccttctaca gaattttctg tatcatccac ctcacgccgc     2040

atataccggt gtcgtaactg cattaacctt cagaatgagg ctcaaaaacg agaatcattt     2100

ttgaagtaca aatgtttact tcaacagctc tactatacag aagctgatta tgaagatgat     2160

tctaaaattg ctttcttgat gcagctacaa gacattcagt acctgacaga gaacatctgg     2220

gcgtcccagt cagtcctcag tgcttgcgac aatctcagtg atctggtcat ggtcagatgg     2280

aataaatccc tggagtggtc cccctggaac tgcattcttc ttaccaaaga tgaagcagct     2340

gctcatctca agctaacaag tattgaagag ggatatgaac gctcatttat tcacaagatc     2400

aaacacaaac atatcctggc taagaactat ttttctcagg ttccagtgct ggcttcattt     2460

atacttgatg atggtgaaat tgatgagatc agatggaagt atcactcaga cacaacacct     2520

aagattatag aatcccagag gcctcctcat taggtgatcc aggagtattt gtttgatgat     2580

cggcattttg ttcactgcta atagggtaat acagaggtca cagagtatgg aaatggaatt     2640

taatctgttt attgattttg ttttttgttt ttcatagtat tttgagttat ataaagagaa     2700

aacatttcta tataagtaag tattctttgt taggaagttg gtgctaaatt gaaatgcaat     2760

tttgttactg aaattaatat tttggggtaa agaaaacatt ttaaaatgtg ttttcacatt     2820

aaatttttta aattttttca agtatattag agttaaaatc taacaaacag ccaaataaaa     2880

actagacaac t                                                          2891


<210> 964
<211> 5598
<212> DNA
<213> Homo sapiens

<400> 964
gagcctgggg aggtcgaggg tgcagcgagc cgtgatcgtg ctactgcact ccagcctggg       60

caacacagag agaccctgtc tcaaaacaaa caaacaaaca aacaaacaaa caaacaaaaa      120

aaacaaagaa aaaaaaatgg gagtgggccg ggcgcggtga ctcacacctg taatcccagc      180

actttcggag gccaaggcgg gtggatcacg aggtcaggaa ttcaagatta gcctggacaa      240

catggtgaaa ccccatctct acgaaaaata caaaaattag ccaagtatgg tggccggcgc      300

ctgtaatccc agctactcgg gagactgagg cagagaactg cttgaacctg ggaggcagag      360

gttgcagtga tccgagatcg cgtcactgca ctccagcgtg ggcgacagag cgagactccg      420

tttcagaaaa gaaaaaaaaa aaaaaaaaaa agggagtcgg ggtggagctc tcattggctc      480

gttgcatgtg agtgtcccta cggcctagaa atacaagaga agcacatcgg aacgggctgg      540

aaatccaccc agttaactag agggctttga accttttatt aacttggagg ttgactctcc      600

tgtcaactcg attccctttt ggctgtttgg cagggtcagt gagacatccc ctgggtcgct      660

cgaccccgta ggacggttca gggagccctc caggtcttcg tttctcctct tccccgcaca      720

gtgctgttat ccagctgggg gatccaacgc acacttaagg ctccagcaaa gtggctccgc      780

tgccggatgg gagtgcccca gtgtgctgga tgaagctggc gcatgcacca tgtcatcatg      840

tgtctctagc cagcccagca gcaaccgggc cgccccccag gatgagctgg ggggcagggg      900

cagcagcagc agcgaaagcc agaagccctg tgaggccctg cggggcctct catccttgag      960

catccacctg ggcatggagt ccttcattgt ggtcaccgag tgtgagccgg gctgtgctgt     1020

ggacctcggc ttggcgcggg accggcccct ggaggccgat ggccaagagg tcccccttga     1080

cacctccggg tcccaggccc ggccccacct ctccggtcgc aagctgtctc tgcaagagcg     1140

gtcccagggt gggctggcag ccggtggcag cctggacatg aacggacgct gcatctgccc     1200

gtccctgccc tactcacccg tcagctcccc gcagtcctcg cctcggctgc cccggcggcc     1260

gacagtggag tctcaccacg tctccatcac gggtatgcag gactgtgtgc agctgaatca     1320

gtataccctg aaggatgaaa ttggaaaggg ctcctatggt gtcgtcaagt tggcctacaa     1380

tgaaaatgac aatacctact atgcaatgaa ggtgctgtcc aaaaagaagc tgatccggca     1440

ggccggcttt ccacgtcgcc ctccaccccg aggcacccgg ccagctcctg gaggctgcat     1500

ccagcccagg ggccccattg agcaggtgta ccaggaaatt gccatcctca agaagctgga     1560

ccaccccaat gtggtgaagc tggtggaggt cctggatgac cccaatgagg accatctgta     1620

catggtgttc gaactggtca accaagggcc cgtgatggaa gtgcccaccc tcaaaccact     1680

ctctgaagac caggcccgtt tctacttcca ggatctgatc aaaggcatcg agtacttaca     1740

ctaccagaag atcatccacc gtgacatcaa accttccaac ctcctggtcg gagaagatgg     1800

gcacatcaag atcgctgact ttggtgtgag caatgaattc aagggcagtg acgcgctcct     1860

ctccaacacc gtgggcacgc ccgccttcat ggcacccgag tcgctctctg agacccgcaa     1920

gatcttctct gggaaggcct tggatgtttg ggccatgggt gtgacactat actgctttgt     1980

ctttggccag tgcccattca tggacgagcg gatcatgtgt ttacacagta agatcaagag     2040

tcaggccctg gaatttccag accagcccga catagctgag gacttgaagg acctgatcac     2100

ccgtatgctg gacaagaacc ccgagtcgag gatcgtggtg ccggaaatca agctgcaccc     2160

ctgggtcacg aggcatgggg cggagccgtt gccgtcggag gatgagaact gcacgctggt     2220

cgaagtgact gaagaggagg tcgagaactc agtcaaacac attcccagct tggcaaccgt     2280

gatcctggtg aagaccatga tacgtaaacg ctcctttggg aacccattcg agggcagccg     2340

gcgggaggaa cgctcactgt cagcgcctgg aaacttgctc accaaaaaac caaccaggga     2400

atgtgagtcc ctgtctgagc tcaaggaagc aaggcagcga agacaacctc cagggcaccg     2460

acccgccccc cgtgggggag gaggaagtgc tcttgtgaga ggcagtccct gcgtggaaag     2520

ttgctgggcc cccgcccccg gctcccccgc acgcatgcat ccactgcggc cggaggaggc     2580

catggagccc gagtagctgc ctggatcgct cgacctcgca tgcgcgccgc gtcgcctctg     2640

gggggctgct gcaccgcgtt tccatagcag catgtcctac ggaaacccag cacgtgtgta     2700

gagcctcgat cgtcatctct ggttatttgt tttttccttt gttgttttaa aggggacaaa     2760

aaaaaaaaaa ggacttgact ccatgacgtc gaccgtggcc gctggctggc tggacaggcg     2820

ggtgtgagga gttgcagacc caaacccacg tgcattttgg gacaattgct ttttaaaacg     2880

tttttatgcc aaaaatcctt cattgtgatt ttcagaacca cgtcagatat accaagtgac     2940

tgtgtgtggg gtttgacaac tgtggaaagg cgagcagaaa actccggcgg tctgaggcca     3000

tggaggtggt tgctgcattt gagagggagt agggggctag atgtggctcc tagtgcaaac     3060

cggaaaccat ggcaccttcc agagccgtgg tctcaaggag tcagagcagg gctggccctc     3120

agtagctgca gggagctttg atgcaactta tttgtaagaa ggatttttaa attttttatg     3180

ggtagaattg tagtcaggaa aacagaaagg gcttgaaatt taataagtgc tgctggaagg     3240

ggattttcca agcctggaag ggtattcagc agctgtggtg gggaaacatt tctcctgaaa     3300

gactgaacgt gtttcttcat gacagctgct caaagcaggt ttctgagata gctgaccgag     3360

ctctggtaaa tctctttgtc aaattacgaa aacttcaggg tgaaatccta tgcttccatg     3420

tacattacat ggcttaagat taaacaaaaa catttttcaa gtctctaact agagtgaact     3480

ctagagcaca gtagttcaga aactatttag agcttccagg atatatttca cagcttcagg     3540

catgtgatca gttagagccg atgaaaccta tgcccgcctg tatatatatt agcagcttag     3600

ctagttcata acctgtatat tctaaagact gctaaggttt tgttttcatt ttaaatccta     3660

gctgattgtt gtggtcaatg aaatacccag tttctggagg gccaggtggg aaatgctttc     3720

actggaccaa cacacaaatg atcatcctga ggatctgagc ttccctagac tccacacaat     3780

aaccttgggg caccctttta gagaagactg ttgaaaccca cagcactcgt tggggtatga     3840

ggaaaccagg gcttggcaca ggaagttccc ctttgtagct aaaagtccag aaagaaaggg     3900

ttcatctttt tgacttccaa ctgatattgg gaagtttggt tgaggttcaa gtgtgactcc     3960

ttccagagcc acaggtaggg gagtgtgaag ttgaggggga ggaaagctgg aaggactctg     4020

ccttgggaga ttcccagctc tgctttccag cgcttggtgg aatctgggct ggggaaagac     4080

ggcaccggga aactctgctt ccccattgtt tccatctgat cagctgtggt gtgaggactt     4140

ctcagacaaa ggcaaggcct cgtgcccctg cccagcccat tcatggagcc ctgggccttc     4200

ttggcttcca tagatcctaa gctcttgact gtagtttagc cagacttgtt ttgctatctt     4260

ataagcagtt cagaattagg gaatgctggt tttgaagagc aaaggacagg tagtctagag     4320

agggtcgtct ggcctgcttg ctgggtcttt gtaacccagc acttcctctt gccctcctgg     4380

ctttatgttt atggggagag gactcaatag ctccacccct tctggcacca gatggggctt     4440

ggttagtttg caataagcac cttgcagagg ttaaagccag cgggtcccta gtcttaggcc     4500

cagcctgctt gtgtgggctc tggcctggcc tggtggctgg cccagggggc agcagtgctt     4560

agagcttctg cagggcttct cttgtttaca cagctgcatc agacaatgcc atttctcccc     4620

accacggaac cttccatcta agatttcttc cagggaatgc cagcaatcag gcagcaccca     4680

gctgtggggg cagtggggtg ggggagaccc acattgatga cttttttttt ttcttttaat     4740

gaagaaacac caaagaaagc tgtggaaagg acctgcccca catgaaaagg ataagccaag     4800

atggctgtaa acacagagca tttgagctgc cactcttgga gcacattgat ttttcaaaag     4860

ccagctctgt caggaaagga ggtgctgtta tgagcagctc ttccagtggg caaagaggac     4920

gcccataatt tcttccattg ctagctcatc tgtgggacca atttggtgta agcaacctgt     4980

ggcctgcact tgtggcctcg aaggaagcac aaaccctcca tccacttccc atttcctctg     5040

cccttttcca cctccccctt ccatcccacc agctgccagt ggctcccaga aagccttatt     5100

gagccccttg ttgacacttg gggctgcgga ggcctctccc tactggtctg gcctttcctg     5160

agaggcaggt cttccgtcct cagagccttt ctggaacaag gagaatgcct gtgcaggtgg     5220

acacacaggc ctggcctgtc gctctcactt gtcttccagc ggggagcttc acgttgccga     5280

gtggaagaac catgacctcc acttgcttcc aaggtgctag ggaagtttca gggtacgctg     5340

gttcccctct ccagctggag gccgagtttc tggggactgc agatttttct actctgtgat     5400

cgattcaatg cccgatgctt ctgtttcatt cccgaccctt tctactatgc attttccttt     5460

tatcaggtgt ataaagttaa atactgtgta tttatcacta aaaagtacat gaacttaaga     5520

gacaactaag cctttcgtgt ttttccacag gtgtttaagc ttctctgtac agttgaaata     5580

aacagacagc aaaatggt                                                   5598


<210> 965
<211> 2433
<212> DNA
<213> Homo sapiens

<400> 965
ggagacagcg gcgtggcggc ggcggtggcg gtagcgacgg cacgccgtag ggcggtcaga       60

aggtttccgg ttccggtgta acgttcgggc tccgtctcag gggctgaagt ttgtgaggtg      120

tagtattgag tcctgtttga gctattgttc tctttttcct gaaaaatggc actgtcaaag      180

agggagctgg atgagctgaa accatggata gagaagacag tgaagagggt cctgggtttc      240

tcagagccta cggtggtcac agcagcattg aactgtgtgg ggaagggcat ggacaagaag      300

aaggcagccg atcatctgaa accttttctt gatgattcta ctctccgatt tgtggacaaa      360

ctgtttgagg ctgtggagga aggccgaagc tctaggcatt ccaagtctag cagtgacagg      420

agcagaaaac gagagctaaa ggaggtgttt ggtgatgact ctgagatctc taaagaatca      480

tcaggagtaa agaagcgacg aataccccgt tttgaggagg tggaagaaga gccagaggtg      540

atccctgggc ctccatcaga gagccctggc atgctgacta agctccagat caaacagatg      600

atggaggcag caacacgaca aatcgaggag aggaaaaaac agctgagctt cattagcccc      660

cctacacctc agccaaagac tccttcttcc tcccaaccag aacgacttcc tattggcaac      720

actattcagc cctcccaggc tgccactttc atgaatgatg ccattgagaa ggcaaggaaa      780

gcagctgaac tgcaagctcg aatccaagcc cagctggcac tgaagccagg actcatcggc      840

aatgccaaca tggtgggcct ggctaatctc catgccatgg gcattgctcc cccgaaggtg      900

gagttaaaag accaaacgaa acctacacca ctgatcctgg atgagcaagg gcgcactgta      960

gatgcaacag gcaaggagat tgagctgaca caccgcatgc ctactctgaa agccaatatt     1020

cgtgctgtga agagggaaca attcaagcaa caactaaagg aaaagccatc agaagacatg     1080

gaatccaata ccttttttga cccccgagtc tccattgccc cttcccagcg ccagagacgc     1140

acttttaaat tccatgacaa gggcaaattt gagaagattg ctcagcgatt acggacaaag     1200

gctcaactgg agaagctaca ggcagagatt tcacaagcag ctcgaaaaac aggcatccat     1260

acttcgacta ggcttgccct cattgctcct aagaaggagc taaaggaagg agatattcct     1320

gaaattgagt ggtgggactc ttacataatc cccaatggct ttgatcttac agaggaaaat     1380

cccaagagag aagattattt tggaatcaca aatcttgttg aacatccagc ccagctcaat     1440

cctccagttg acaatgacac accagttact ctgggagtat atcttaccaa gaaggaacag     1500

aaaaaacttc ggagacaaac aaggagggaa gcacagaagg aactacaaga aaaagtcagg     1560

ctgggcctga tgcctcctcc agaacccaaa gtgagaattt ctaatttgat gcgagtatta     1620

ggaacagaag ctgttcaaga ccccacgaag gtagaagccc acgtcagagc tcagatggca     1680

aaaagacaga aagcgcatga agaggccaac gctgcccgaa aactcacagc agaacagaga     1740

aaggtcaaga aaattaaaaa gcttaaagaa gacatttcac agggggtaca catatctgta     1800

tatagagttc gaaatttgag caacccagcc aagaagttca agattgaagc caatgctggg     1860

caactgtacc tgacaggggt ggtggtactg cacaaggatg tcaacgtggt agtagtggaa     1920

gggggcccca aggcccagaa gaaatttaag cgtcttatgc tgcatcggat aaagtgggat     1980

gaacagacat ctaacacaaa gggagatgat gatgaggagt ctgatgagga agctgtgaag     2040

aaaaccaaca aatgtgtact agtctgggag ggtacagcca aagaccggag ctttggagag     2100

atgaagttta aacagtgtcc tacagagaac atggctcgtg agcatttcaa aaagcatggg     2160

gctgaacact actgggacct tgcgctgagt gaatctgtgt tagagtccac tgattgagac     2220

tactgcaagc ccttgcctct cctcccttgc ctttgtctct tcagtcctct cacttattct     2280

atttcccaac cccctcccac ttgtttgtgt gatctcagaa ctgtgccaag cagacactgg     2340

gacaaaggga gaatatcttg ctcccctcct gagtcagcct ggtgttgccc tttattcccc     2400

ttatgtgcat atgattaaag agttattttt aaa                                  2433


<210> 966
<211> 2950
<212> DNA
<213> Homo sapiens

<400> 966
ctgggagaga ggaagtgatc gctcccggag gagcgcgagc cgagcggccg gcgcagcgtg       60

agacagcaca tcctgcccgc gccggccccg ccaccttcgg gagccgcctg caccaacgct      120

gccgccgccc aggagccgcc gccggctcgg ggagcccagt tccgccgctg ccgagcgcgt      180

ccaggaaacc aacatgtctg acaaaagtga cttaaaagct gagctagagc gcaaaaagca      240

gcgcttagca cagataagag aagagaagaa acggaaggaa gaggagagga aaaagaaaga      300

ggctgatatg cagcagaaga aagaacccgt tcaggacgac tctgatctgg atcgcaaacg      360

acgagagaca gaggctttgc tgcaaagcat tggtatctca ccggagccgc ctctagtgca      420

gccgctgcat tttttaacat gggatacctg ttattttcat tatttagtcc caacccctat      480

gtctccctcc tcgaaatcag tgagcactcc cagtgaagct ggaagccaag actcaggcga      540

tctggggcca ttaacaagga ccctgcagtg ggacacagac ccctcagtgc tccagctgca      600

gtcagactca gaacttggaa gaagactgca taaactgggc gtgtcaaagg tcacccaagt      660

ggatttcctg ccaagggaag tagtgtccta ctcaaaggag acccagactc ctcttgccac      720

gcatcagtct gaagaggatg aggaagatga ggaaatggtg gaatctaaag ttggccagga      780

ctcagaactg gaaaatcagg acaaaaaaca ggaagtgaag gaagcccctc caagagagtt      840

gacagaggaa gaaaaacagc agatccttca ttcagaggaa tttctcatct tttttgaccg      900

gacaatacgg gtaattgaaa gagccctggc tgaagattcc gacatctttt ttgactacag      960

cggccgagag ttagaggaaa aagatgggga tgttcaggct ggagccaatc tttctttcaa     1020

tcgtcagttc tatgatgaac attggtccaa gcatcgagtg gtcacttgta tggactggtc     1080

cctccagtac cctgagctga tggtggcttc ttacaacaac aatgaagatg ctccccatga     1140

accagatgga gtggccttgg tttggaacat gaagtttaag aaaaccacac cagaatacgt     1200

cttccactgt cagtcctctg tgatgtcggt ctgcttcgcc cgtttccatc ctaacttggt     1260

ggttggtggg acttactcgg gccagattgt cctctgggac aatcgcagtc atcgaaggac     1320

tccagtgcag cggacaccct tatcagctgc tgcacacacg catcccgtgt actgtgtaaa     1380

tgttgttggg acccagaatg ctcataacct catcactgtc tccactgatg gcaaaatgtg     1440

ttcctggagc ctggacatgc tctcaactcc acaggagagc atggagctgg tgtacaataa     1500

gtccaagcct gtcgctgtta ccggaatggc tttcccaacg ggagacgtca ataacttcgt     1560

ggttggcagt gaggaaggta cagtctacac ggcttgtcgt catggaagca aagcaggtat     1620

tggtgaggtc tttgaaggtc accaagggcc agtgacagga attaactgcc acatggcagt     1680

gggcccaatc gacttttctc acctgtttgt cacatcatca tttgactgga ctgtcaaact     1740

gtggaccacc aagcacaaca agccgctcta ctcctttgaa gacaatgcag actatgtgta     1800

cgatgtcatg tggtcccccg tgcatcctgc gctttttgcc tgcgtggacg ggatggggcg     1860

cttggacctc tggaacctca acaatgacac cgaggttcca acagcaagtg tggccattga     1920

gggggcatcc gccctaaacc gtgttcgttg ggcccaagct ggcaaagaag ttgctgttgg     1980

ggactcggaa ggccgtattt gggtctatga cgttggagag cttgcagttc cccacaatga     2040

tgaatggacc cgatttgcca ggacccttgt ggaaattcgt gctaacagag ctgatagcga     2100

ggaggaaggc actgttgagt tatctgccta gtggaaatga gccaccccca ctgcagcccc     2160

cacctttgtg tcctagagct cagcgtctgc agtcaagtct cttgtattcg gtgtccattc     2220

agtatcagta ttgctgtgat attttgggtg ccatattgtg ccagctttgc tccaagtatt     2280

ctaaatgtgt cccatcatgc tttccactga cccaaaattc accacagcat ttctatcttt     2340

atatttctgt ctcaaaaatg aagagaaggg ggttatgggt taagttgctg ccttttaact     2400

actttgtagc tgtatttaat agctggaaac ctctggttaa atttgtgctt acatgcactc     2460

ctggcatagt cctattaaat ccatatgaag ccagatatga ttgggtgcag atgtggtgtt     2520

cctcatatta tggtacaggg ccaaagactt gagacgtggt gttttacatg gtgactcaca     2580

ttatgaatgg atttactaga agaacattgc tgctccttat ttattgtagt gtgctgcatg     2640

gaacgtattt atttgaaagc attaaaataa atgatcctag agcatgtgca taatgagagg     2700

actgtattct ctctgctgct gttgaggtta tattaagttc cacatagcaa ttacagtatg     2760

ccagttccac tgaagacatg aaatctttag aggtttcttg cagtgaacga aatgaatttt     2820

aatgcctatt atttctgggt actttaacaa tatttcaaat atcattgacc actaatactt     2880

ctcactgaag ctaacacagt ctgacaaaag tctatggttc ctaaatatga catcagtgtt     2940

gccaataaaa                                                            2950


<210> 967
<211> 8055
<212> DNA
<213> Homo sapiens

<400> 967
atgacggaag tgacggcggc tcggcgatgg ctctcccgca ggcgcagaaa cggctgctgg       60

gcagctgatg ggcaggagct taccaggctg gcttgctctg agctgcggtt actgtgtcca      120

ggccccgggt tctcagaact gtcatacata aagtacacag aaatgaagag aaaagtcgtg      180

aatactcaca agctgagatt gagtcctaat gaggaagcct tcattttgaa ggaagattat      240

gaaagaaggc gaaaactaag attgctacag gttcgagaac aagaaagaga tatcgcctta      300

cagataagag aagacataaa acagaggaga aatcaacaat ttacacgttt ggcagaggag      360

ctaagggcag aatgggaaga atcacaaact cagaaaatac agaacttgga aaaactgtat      420

ttggcaagtt taagaagtat gggagaggga catcgacagg ccaaagaaaa tgaacctgat      480

ttggatgctt tggcacagcg ggcagcagaa aggaaaagaa aagcagattt gaggcataaa      540

gaagccttga aagtacagaa aaatcaaaaa gaaatattac tgaaacaaaa aacctggcat      600

ataaaagctc gaaaggaagc actgcttgtg gaaaaagaga gatcagccaa aattacaagt      660

ctgccacctc ctcctccaac tctttttgag aacatcgaag taaaaagaat ttctgcagtc      720

aaaaccaata gttctaccta ccatcatctt cacacttttg tgaatagaga gacagacaca      780

aaacggccag atgctcgttt ggctgctgaa gaggaagcta aacgattgga agaactacaa      840

aaacaggcag cacaagagag aatggaacgg tttgaaaagg cacatgtacg gggattccaa      900

gcaatgaaga agatccattt ggctcaaaat caggagaaac taatgaaaga actcaaacag      960

ctacagcaag aggacctggc acgtaggaga cagactgtag cacaaatgcc accacaacta     1020

gttgaacttc catacaaacg cagtgaaatg aaagaagact ggcagagaga attggaattt     1080

gcctttgaag atatgtacaa tgcagacagg aaggtgaaag ggaatctgat tctgcacctt     1140

gaaccagagc ccttgcccac tgtgactaat cagatccaag atgaagagct ggacctttca     1200

atggaacaag aaaatttggg tgcagctgaa gaccttccag tgacagaagc tgaaatatgt     1260

tctagtgaaa cagatgttcc cttggtaatg aagacccaac agattccttc aaaagttctt     1320

tttaaaaaat tattaaataa gatccgaagc caaaaatctc tctggacaat taaatctatg     1380

tctgaggatg aaagtgaaat gattacgact gttagtgaaa ttgagagtaa agcaccaacg     1440

gttgagtcag gaacaattgc cagcaaagag agaacgttat cctctgggca ggaacaagtt     1500

gttgaaagtg atacactaac aattgagtct ggaccacttg ctagtgaaga taaaccactt     1560

tcgtgtggta caaactctgg aaaagaacaa gaaataaatg agactctgcc tatcacaact     1620

gtagctcaga gttcagttct acttcatcct caagaagcag cagccaggat tagaatgtca     1680

gcaaggcaga aacagataat ggaaatagaa gagcagaagc aaaagcaatt ggaattactt     1740

gaacaaattg aacagcagaa attaagatta gaaactgact gcttcagggc tcagctggaa     1800

gaagaaaaaa gaaaaaaaac tcaaccgact ggggttggca ttgctccagc atcatgccct     1860

gtaatttctg atgaagatag tcataggcag atgattcgta actatcaaca tcagctttta     1920

caacaaaaca ggttacacag gcagtctgtt gaaacagcca ggaaacaatt acttgaatat     1980

caaactatgt taaaaggaag gtgcccatcg gtgtcagctc catcattgat aactgattct     2040

gttatatcag tgccatcatg gaaatctgag agaccgactg ctatatcaga gcattgggat     2100

caaggtcaga gactcaagtt gagtcctaac aaataccaac ccatacaacc tatacagacc     2160

tccaaattag aacaagatca ttttcaggta gcgagacaaa atcactttcc acaaagacag     2220

gtggaaacaa cagaaacatt acgcgcttca gatattttaa ccaatcaagc tttagaatca     2280

caagaacatc taaggcaatt ctctcagact gaaacacaac agagagacta taaattggtc     2340

cccaaagatt ctgagacact ttcaagggct ttgtcacatg acaggcagct aatatcacag     2400

gatgctagaa aaatatctga aacatttggg gcaacaactt ttcaaagttt agaatcccaa     2460

caattgttct cagagaatag tgaaaatata tcttaccatt taactgaacc ttcttcattt     2520

gtaccactgg tacctcagca ttcttttagt tctctgcctg ttaaagttga gtcaggaaaa     2580

attcaagaac ccttttcagc catgagcaaa agtacagttt ccacaagcca ttctataatc     2640

agccaaatgc atgataggcc tttgctgccg tcagagaata tcacagccca gcaaggtaat     2700

atgaaggccc tccaagaaca gttagaccta cagaagaaag ttcttcaggc aactcaggaa     2760

gctcaggaac agttgctttt gtgcaaacag aaagaagtgg aacagcaaac gggcctctcg     2820

gtattccttc ccttggtaac tccagattca tctgctttat tgccttctgc caaagcagat     2880

ttggggagaa tccaggaatc ttcaccaacc aagaataata ttgcagtttc ctcagaccat     2940

catgtgatct cacaacttca ggataagcgt ttgagtcttt cacagcctat cctatcacag     3000

caaaataatt ttaaatttct ccaagagcag ttgaatattc agaaggatag ccttcaggct     3060

aggcgagaag cccaggaagt attgtatgta cataaacaga gtgaattgga tagaagagta     3120

tgttccgaac aggctgagcc ctctttccca tttcaggtag ctcagcatac atttacttca     3180

ctaccatctg ctgatacaaa atctggaaaa atacaggagc aacattcatc taagagcgag     3240

aaaggacttg tttcatgcca atctgacatc cccatatctc aggatgggtc tttgagtttc     3300

ctacagcagt tcctacctct acatgatagt ttgaagttgc tccaagaaca gttgactaaa     3360

cagagggata ctcttcaggc taggcatgaa gctcaggtgg aattactttt acatagacaa     3420

agagatttgg gggacagtaa gtctgggctg gtgagctctt catcctcacc agtggttgtt     3480

cagcattcag ttgcttcaca agcttctgct aaagctgagc ctaggagaat tcaggagctt     3540

tatttatctg agaaggagaa tgtaggtccc tcctgtcatt tgataatccc aacatttcag     3600

gataagtctc ttagttttcc acagcatagc ctggcacagc aagaaaattt gacaatactc     3660

caagaacagt cacaaataca aagggtaata cttggtgcta aagaaggaac tcaggaattt     3720

gtacacacag aaagtgaatt ggagaaaaga atttcttctg aacagactgg cacctcctca     3780

tccctttccc aggtggatga atctgagaga ttccaggaat gtatatcaat caagagtgac     3840

agtaccattc ccttaagcca tcctaagatc ccaagatgtc aggaaagact tttgagagtt     3900

tcacaacata tgctacctct acaagataat ttggaggaac accaagcatg gctagacact     3960

gagaaagaag cctttcattt cagccagaaa acccaagaaa atacatcttc tgaacaaact     4020

ggttcatctt cattcatacc ccagttggta cagctttcat ttacttcgtt agcttcagct     4080

gagtctggca caatcctgga acctcttttt acagagagtg aaagtaaaat tttttcaagc     4140

caccttcaga tcccacaatt gcaggatagg cttttgagga tatcgcaact tatccagcct     4200

caacaagata atttgaaggc acttcaagaa cagttagcta cacagagaga agccatcatt     4260

ctagctagac aagaagctcg ggaagaatta cttttacatc agagtgaatg ggagggaaga     4320

atatctcccg agcaggttga cacctcttcc ttacccctag taccacagca ttcattcgcc     4380

tcattacctc ttaatgaatc tgaaagaaac caagaaccat gttcaattaa cagtgataat     4440

atagtatcct caggtcactc agagatacca acattgcctg atgggctgtt gggtttatca     4500

catcttgttt tacctcaaca agataatttg attgcacttg aagaacactt gcatgcacag     4560

acagatttcc ttccttctat tgagaaaacc cagaaagaat tggttttgtc aaaaccatgt     4620

aaatttgagg aaaaggtatc ttctgagcat tttatccagt ctcaccatgg tgatttgcag     4680

gcacttcaac agcagttaga tacacagaag aaagccattc gatctataca ggaagtccaa     4740

gaagaattgc ttttgcaaag attaagtgaa ttggagaaaa gggtatcatc tgaacaagtt     4800

tgctcctctt catttgtatc ccaggtgcct gttgctgact ctgaaagaac ccagaagtct     4860

ttcccaacca aaagtaatga tactcttccc tcaagtcatc gtgagattcc aagattacag     4920

gatagacttt tgagtttatc aaagcctatt ctgcctcagc aagataatat gacagcacaa     4980

ttggatgcac aaagggaagt gatgtattct tatgagaaac cccaggaaga actgtcttta     5040

aacaaacaaa gaaagttgaa caaaagtgaa tctgctgagc atactatccc ctctttgttt     5100

ctacccaagg aaacagagca ttcgtttatt ccactacctt ttgcagaagc taaacctaaa     5160

agcacttgtg aattgtattc atcccagaat gaacatgcag cccccccaag taatcctgtg     5220

atcccagggt ttcaagatag acttttgagt ttttcacagt ctgtcttaac tcagcaagat     5280

aacttgggac ttcagaaaca gttggatcta caaagagaag ttctgcatta tagccagaaa     5340

gcccaggaaa aattgcttgt acagagacaa acagcattgc agcagcagat acagaaacat     5400

gaagagactt tgaaggattt ctttaaagac agtcagataa gtaagcccac agttgaaaat     5460

gatttaaaaa cccagaagat ggggcagctc agagactggt ttcctaatac acaagaccta     5520

gcaggaaatg atcaagaaaa tattaggcat gcagatagga acaactctga tgataatcat     5580

ttggcttcag aagatactag tgccaagcaa agtggtgagc atctggagaa agatctgggg     5640

agaagatcct caaagccacc tgtagcaaaa gtcaaatgtg gtttggactt aaaccagcat     5700

gaacttagtg ctatacaaga agtagagtca ccagcaattg gcagaacttc tatactaggt     5760

aaaccaggta tttatgaaga cagagacccc ctgcgagtct caataagccg agaacaaagt     5820

ttctttggga gcccactggc ccatgatccg tttagttgtc ttcaactggt tggccaagag     5880

aatgtctgtg gtgatgacta tgatgaagca gttaagctga aggaatctgt tgttgaaaat     5940

catgcagtgt taagttatgc tgtggaggaa gaacatgcat atttgggtcc aactgtgaag     6000

ccagatgata aggctaaaac actgtcttat gaaccattat cttcagcaac tgtttccact     6060

gggagccttt taagttatga aaacacagat ttgagcctta cagatccaga gtcattttca     6120

gagcacatgg atgatagcaa gcaagaatct accaccagta aagaagagga aacaaatatt     6180

ataagttcca tagttccttc aacacaagat atttatcagc ggcagaactc ttcagacgtt     6240

cataaatctc tgttgcctgc agtggatgaa actacatgtg gtcacacaca ctttcagcaa     6300

atgatagaca agtacattaa tgaagcaaat ttgatacctg aaaaaacaga tttgcaagaa     6360

ttggaacaca tttttcctaa tttgcatcat cagctgttta aacccttaga accacatcca     6420

gattttgact tatcatcatc atcctctggg atttctccag acaacagaga cttttaccag     6480

agatcagatt cttcatctga aagccactgt gctactggat tatccaaaag tacagtttat     6540

ttcacagcac tgaggaggac cagcatgcat tcttctctta acacaagtcc gaatcaacaa     6600

cctgacacta acttggctca tgttggagct cacagttttg ctacagaaaa tattattggg     6660

ggatctgaac aatgttttga acagcttcag ccagaatatt cttcacagga ggagagccag     6720

catgctgatc taccaagtat ttttagcatt gaagcaagag attcttccca aggcatgaaa     6780

aatcagaact atccctctga agaacatact gaaatattac aaaacaagaa aaaaattgtt     6840

catttccagc tttctatagg aaacttaagt tcagtctaca gttcatctga tgaagctaat     6900

gtatttgatc agttaaatgt acagcatagc actccatgtg gttctaactc tagtgagtgc     6960

tcaacaaaac accaactaga aagcagaaag gaaagtatgg gctttgaaga actatcaaaa     7020

agaggggttg ttacaatgtt acaaagtcaa ggactcattg aagataataa aaatgaaacc     7080

tgtagggttt tagacataaa tccacaggta gaggaaactg actctcgatt atgtgtaaga     7140

acagtggaga tgggaacttc aattcaggca ccatattcct taactactca aaatgaaaaa     7200

tattttgaga attcagctga aacagacatt ccaaaaatca ccaaaaaact atctcaacta     7260

ggagaatcag agctttttgc aagttctgga tcattttcat tacagagctc tataccagtc     7320

tgggaaacag aaactggcca tggtataatg gaagaaccag aacttacttt aataagcacc     7380

actgatacca gtattgctga aatggatttt gcaaatttaa ccctagaaga gaagagcgag     7440

aatgaagcaa aatgcttctt tcaggtgagt gagtttctgc ctcttgtatc agcaacagaa     7500

gcctcagatt atccagctgt atcagaactt tccatagaaa aaccaaggac agcatctaca     7560

gaaacccctc gcaggcttac acctgtacca gggagcttac aagaagcatt tataaagagg     7620

aaaaaatcat ttatggagag atcccaccag aggcagaaag aaataaggaa taaaattcat     7680

gtctctgaaa attctcaaat caaaacagtt aaagagaaac catctataag ttcatctgtg     7740

agtcgtctaa agggcgtgaa taaagtcaga gcatcttttc ctgaagacag aaagactaca     7800

caggctctaa ggcaccaaag gggtctaagg ttatacaatc aactagctga agtgaaacaa     7860

caaaaggaag aaaaaacaaa acaagaagct tatgcccaaa acagagcaag ggcaaaagaa     7920

ttccataaga aaacactaga gaaacttcga gccaaaaata catgctgact ttctagaaat     7980

agtgtaaagg ttttttaatt gtgtatatgt agcattagac aaaattattt aaagtcaata     8040

aattgttatt cgagg                                                      8055


<210> 968
<211> 2857
<212> DNA
<213> Homo sapiens

<400> 968
ctcttggcgg gtgccggcca tggcggcttc gctcccggga cctgggagcc ggcttttccg       60

cacatatggg gctgcggacg gcaggagaca gcggcggccg ggccgggaag ccgcgcagtg      120

gttcccgccg caggaccgga ggcgtttctt caacagcagc ggcagcagcg acgccagcat      180

cggcgacccc tcgcagtccg acgatcctga cgatcccgac gaccccgact tccccggcag      240

cccggtgagg cggcggcgga ggcgtcccgg cggccgagtg cccaaggacc ggcccagcct      300

gaccgtgacc ccaaagcgct ggaagctgcg agctcgccca agcctaaccg tgaccccaag      360

acgcctgggg ctgcgagctc ggcccccgca gaagtgcagc acaccctgcg gcccgctccg      420

acttccgccc ttccccagcc gcgactccgg ccgcctcagc ccggacctca gcgtgtgcgg      480

ccagcccagg gacggcgacg agctgggcat cagtgcctcc ctgttcagct ctctggcctc      540

gccctgcccc gggtccccaa cgccaaggga cagtgtcatc tcgatcggca cctccgcctg      600

tctggttgca gcctcagccg tcccgagcgg cctccacctc ccagaagtct ccctggaccg      660

agcatctctc ccctgctccc aggaggaagc gacaggagga gccaaggaca ccaggatggt      720

ccaccaaacc cgcgccagcc tcaggtcagt tctctttggc cttatgaact caggaacccc      780

tgaggattct gagtttcggg cagatgggaa gaatatgaga gagtcctgct gtaaaaggaa      840

actggtggtg ggaaatggac cagagggtcc aggtctgtca agcacaggca agaggagggc      900

cacaggccag gactcttgtc aagagagagg gcttcaagag gccgtccgga gagagcatca      960

ggaggccagt gttcccaagg gccgcattgt gccaagggga atagacaggc tggagagaac     1020

tagatcaagc cggaagagca aacatcagga ggcaacggaa acctctctcc tccattccca     1080

ccgctttaaa aagggccaaa agctgggaaa agattcgttc cccacccagg acctgactcc     1140

tttacagaat gtctgctttt ggaccaaaac cagggcttcc ttcagtttcc acaagaagaa     1200

aattgtgact gatgtgtcag aggtctgcag catctatacc actgccactt ctctctctgg     1260

atccctccta tcagaatgtt caaaccggcc tgtcatgaac agaacaagtg gtgctccgtc     1320

ctcttggcac tcctcctcta tgtatttgct aagcccctta aacactctaa gtatttcaaa     1380

caaaaaggca tctgatgctg aaaaggttta tggggaatgc agtcagaagg gtcctgtccc     1440

ctttagccat tgccttccca cagaaaaact gcaacgctgt gagaagattg gggaaggggt     1500

gtttggcgaa gtgtttcaaa caattgctga tcacacaccc gtagccataa aaatcattgc     1560

tattgaagga ccagatttag tcaatggatc ccatcagaaa acctttgagg aaatcctgcc     1620

agagatcatc atctccaaag agttgagcct cttatccggt gaagtgtgca accgcacaga     1680

aggctttatc gggctgaact cagtgcactg tgtccaggga tcttaccctc ccttgctcct     1740

caaagcctgg gatcactata attcaaccaa aggctctgca aatgaccggc ctgatttttt     1800

taaagacgac cagctcttca ttgtgctgga atttgagttt ggagggattg acttagagca     1860

aatgcgaacc aagttgtctt ccttggctac tgcaaagagc attctacacc agctcacagc     1920

ctccctcgca gtggcagagg catcactgcg ctttgagcac cgagacttac actgggggaa     1980

cgtgctctta aagaaaacca gcctcaaaaa actccactac accctcaatg ggaagagcag     2040

cactatcccc agctgtgggt tgcaagtgag catcattgac tacaccctgt cgcgcttgga     2100

acgggatggg attgtggttt tctgtgacgt ttccatggat gaggacctgt ttaccggtga     2160

cggtgactac cagtttgaca tctacaggct catgaagaag gagaataaca accgctgggg     2220

tgaatatcac ccttatagta atgtgctctg gttacattac ctgacagaca agatgctgaa     2280

acaaatgacc ttcaagacta aatgtaacac tcctgccatg aagcaaatta agagaaaaat     2340

ccaggagttc cacaggacaa tgctgaactt cagctctgcc actgacttgc tctgccagca     2400

cagtctgttt aagtaagcta aatgtatctt actgccccga aatgagagga gactggtctt     2460

gaagcctctg gtgctgtttc aacctccatc cccacaggag ggtggaactc ccattctcac     2520

aggtttccag tcagcttttc aaacaagaat tttgtttcca aatggaaact gaaatatttg     2580

ttgaaatgtt taaatttgct gataacaaat gttctgaaag aagtaaacta gccgggcaca     2640

gtggcgtgcg cctgtagtcc cagctactcg ggaggctgag gcaggaggat cgcttgagcc     2700

caagagttca tatctagcct ggtcaacata gcaagacccc tgtctctatt tttttaaata     2760

aataaactac atgtgaaaac aaacgtttat atttataaac cctctttttt ttttttttaa     2820

ttttattgag acagagtctt gctctgtcac ccaggct                              2857


<210> 969
<211> 1855
<212> DNA
<213> Homo sapiens

<400> 969
aggcgcagtc ccgcgttccc tcggcggctg ccggcgtagt gagcccgccg ccgtggagtg       60

tagcggaaag ggctcgccgt cctcctccgt ttctcgctgc ttcgggacgc gctctctgcg      120

gctctgtgag cgcccctgag cgccggcagc ggccgcggtg ggttcttcag gttatcttat      180

gatgaggctt ttgctatggc taatgatccc ttggaaggct tccatgaagt aaaccttgct      240

tcacctactt ctccggacct tcttggtgtg tatgaatcag gaactcaaga gcagactacc      300

tcaccaagtg tcatctaccg gccacaccct tcagctttat cctctgtacc tatccaggca      360

aatgcattag atgtttctga acttcctaca caacccgtgt attcatcccc cagacgttta      420

aattgtgcgg aaatatctag tatcagcttt catgttacag acccagcccc ttgctctacc      480

tctggagtca cagctggatt aactaaatta actacaagaa aggacaacta taatgcagag      540

agagagtttt tacagggtgc tactataaca gaggcttgcg atggcagtga tgatattttt      600

gggttgagta ctgatagtct gtctcgttta cgaagcccat ctgttttgga agttagagaa      660

aagggctatg aacgattaaa agaagaactc gcaaaagctc agagggaact gaagttaaaa      720

gatgaagaat gtgagaggct ttcaaaagtg cgagatcaac ttggacagga attggaagaa      780

ctcacagcta gtctatttga ggaagctcat aaaatggtga gagaagcaaa tatcaagcag      840

gcaacagcag aaaaacagct aaaagaagca caaggaaaaa ttgatgtact tcaagctgaa      900

gtagctgcat tgaagacact tgtattgtcc agttctccaa catcacctac gcaggagcct      960

ttgccaggtg gaaagacacc ttttaaaaag gggcatacaa gaaataaaag cacaagcagt     1020

gctatgagtg gcagtcatca ggacctcagt gtgatacagc caattgtaaa agactgcaaa     1080

gaggctgact tatccttgta taatgaattc cgattgtgga aggatgagcc cacaatggac     1140

aggacgtgtc ctttcttaga caaaatctac caggaagata tctttccatg tttaacattc     1200

tcaaaaagtg agttggcttc agctgttctg gaggctgtgg aaaacaatac tctaagcatt     1260

gaaccagtgg gattacaacc tatccggttt gtgaaagctt ctgcagttga atgcggagga     1320

ccaaaaaaat gtgctctcac tggccagagt aagtcctgta aacacagaat taaattaggg     1380

gactcaagca actattatta tatttctcct ttttgcagat acaggatcac ttctgtatgt     1440

aactttttta catacattcg atacattcag cagggactcg tgaaacagca ggatgttgat     1500

cagatgtttt gggaggttat gcagttgaga aaagagatgt cattggcaaa gctgggttat     1560

ttcaaagagg aactctgatg ctctgcgtgg gaccatgcct gaactccccg aataactgaa     1620

aaatggctga atatttttat ggttacttga tatttatttc caaggagtga gcctaagact     1680

tttttcccct tttgcaaatt gctctaagaa gtaccatgat ttcttttaaa ctgatctatg     1740

ctgtgtttgc ttattcttta gttgaacaca ctatgaagaa ttccaggtgt actagtgaat     1800

gtaatttata gttgccaaaa aaaaaaaaaa cctgaaataa ataaatgtta gattg          1855


<210> 970
<211> 1880
<212> DNA
<213> Homo sapiens

<400> 970
agggaagtga agccagtagg agactgagag attagaagaa cagggcagta gaggatgaat       60

ttgcagtgag gttaaaggaa caatttattg ggagaaggga atgtaggagg gtagaagact      120

ttaaaattga aaagaaataa aaggaggcag ggatgtaaaa cgagccataa gtacaatgac      180

aaatgggcat taaggaggaa aaagactatg tagaagaatc tggtaaatat ggatattaac      240

agcaataagc tcctttttaa cgatttaatt ctaccaagta aatatttggg attactcgct      300

ttttgccttt tatttaccaa aaaattcata tattttcaaa ggaacagcta ccggacctgc      360

atagccattt ttctgatctg aacctggaag ctcatatgta tgcatcccag tggtttctca      420

ctctttttac tgccaagttc ccactctgca tggtgttcca catcattgac ttactgcttt      480

gtgagggttt gaacataatc tttcatgtag ctttggctct cctaaagacc tcaaaggaag      540

accttctgca ggctgatttt gaaggtgctt taaagttctt tagagttcag cttccaaaga      600

gatacagggc agaggaaaat gcaagaagac tgatggagca ggcttgcaat attaaagtac      660

caaccaagaa gctgaagaaa tatgagaaag aatatcagac aatgcgagag agtcagctgc      720

aacaggaaga cccaatggat agatacaaga gggagaaccg aagattacag gaggccagca      780

tgaggttgga acaagagaat gatgaccttg cccatgaact agtaacaagc aaaattgctc      840

tacggaatga cttggatcag gcagaagaca aggcagatgt gttgaataaa gagctccttt      900

tgaccaaaca gaggctggtg gagactgaag aggagaagag gaagcaagag gaagagactg      960

cccagctaaa agaagtcttc aggaaacagc tagagaaggc agaatatgaa ataaagaaga     1020

ctacagctat cattgctgag tataaacaga tctgttcgca gttgagtacc aggctggaga     1080

aacagcaagc agccagcaag gaggagctgg aagtggtaaa gggtaagatg atggcatgca     1140

aacactgcag tgacattttc agcaaggagg gtgctttgaa actagcagcc acaggcagag     1200

aggaccaggg aattgaaaca gatgatgaga aggactcact taagaagcag ctgagagaga     1260

tggaactgga actggcacaa accaaactgc agttggtgga ggccaagtgt aaaattcagg     1320

aacttgaaca tcagagagga gcccttatga atgaaatcca agctgcgaaa aactcttggt     1380

ttagcaaaac cctgaactct atcaaaacgg ccacgggcac ccagccattg cagccagcac     1440

cggtcaccca gccacccaag gagagcacat agttccagcc ttacccaagc acaagagcac     1500

aatgttcaaa ccaatggaaa tctgggagga ttcttcctgg tgtccctttg aaggaaagtc     1560

aaggaggcca gaaaacaagc cagaattttt cagtagctct cactctttct tgtatgacac     1620

ttttcaaagg gatgctattt aaactgacct gttctatgtt gaatacctat tttccagctt     1680

ctggaaggcc atgttcagat ccatcatagt attacacatt attttgtttg cctgatgttt     1740

agttggaaat aagtaattca gaactaaatg cttttttatt tagaattatt cataattatt     1800

tttatcttac ataaaaatgg agacatctgt tattccaagg ttgaagtgat aagaagatct     1860

ttgtcacagg aaaaaaaaaa                                                 1880


<210> 971
<211> 3825
<212> DNA
<213> Homo sapiens

<400> 971
gagatgctgt ttggcgactc gtcgccattc ccggagcagg tcggcctcgg cccaggggcg       60

agtatccgtt gctgtgtcgg agacactagt ccccgacacc gagacagcca gccctctccc      120

ctgcctcgcg gcgggagagc gtgtccggcc ggccggccgg cggggctcgc gcaacctccc      180

tcgcctcccc ttcccccgca gcctccgccc cgccaggccc ggcccggact cccgagcccc      240

ggcctcctcg tcctcggtcg ccgctgccgc cgggcttaac agccccgtcc gccgcttctc      300

ttcctagttt gagaagccaa ggaaggaaac agggaaaaat gtcgccatga aggccgagaa      360

ccgctgccgc cgccgacccc cgccggccct gaacgccatg agcctgggtc cccgccgcgc      420

ccgctccgct ccgactgccg tcgccgccga ggcccccgtt gatgccgctg agctccccca      480

acgccgccgc caccgcctcc gacatggaca agaacagcgg ctccaacagc tcctccgcct      540

cttcgggcag cagcaaaggg caacagccgc cccgctccgc ctcggcgggg ccagccggcg      600

agtctaaacc caagagcgat ggaaagaact ccagtggatc caagcgttat aatcgcaaac      660

gtgaactttc ctaccccaaa aatgaaagtt ttaacaacca gtcccgtcgc tccagttcac      720

agaaaagcaa gacttttaac aagatgcctc ctcaaagggg cggcggcagc agcaaactct      780

ttagctcttc ttttaatggt ggaagacgag atgaggtagc agaggctcaa cgggcagagt      840

ttagccctgc ccagttctct ggtcctaaga agatcaacct gaaccacttg ttgaatttca      900

cttttgaacc ccgtggccag acgggtcact ttgaaggcag tggacatggt agctggggaa      960

agaggaacaa gtggggacat aagcctttta acaaggaact ctttttacag gccaactgcc     1020

aatttgtggt gtctgaagac caagactaca cagctcattt tgctgatcct gatacattag     1080

ttaactggga ctttgtggaa caagtgcgca tttgtagcca tgaagtgcca tcttgcccaa     1140

tatgcctcta tccacctact gcagccaaga taacccgttg tggacacatc ttctgctggg     1200

catgcatcct gcactatctt tcactgagtg agaagacgtg gagtaaatgt cccatctgtt     1260

acagttctgt gcataagaag gatctcaaga gtgttgttgc cacagagtca catcagtatg     1320

ttgttggtga taccattacg atgcagctga tgaagaggga gaaaggggtg ttggtggctt     1380

tgcccaaatc caaatggatg aatgtagacc atcccattca tctaggagat gaacagcaca     1440

gccagtactc caagttgctg ctggcctcta aggagcaggt gctgcaccgg gtagttctgg     1500

aggagaaagt agcactagag cagcagctgg cagaggagaa gcacactccc gagtcctgct     1560

ttattgaggc agctatccag gagctcaaga ctcgggaaga ggctctgtcg ggattggccg     1620

gaagcagaag ggaggtcact ggtgttgtgg ctgctctgga acaactggtg ctgatggctc     1680

ccttggcgaa ggagtctgtt tttcaaccca ggaagggtgt gctggagtat ctgtctgcct     1740

tcgatgaaga aaccacggaa gtttgttctc tggacactcc ttctagacct cttgctctcc     1800

ctctggtaga agaggaggaa gcagtgtctg aaccagagcc tgaggggttg ccagaggcct     1860

gtgatgactt ggagttagca gatgacaatc ttaaagaggg gaccatttgc actgagtcca     1920

gccagcagga acccatcacc aagtcaggct tcacacgcct cagcagctct ccttgttact     1980

acttttacca agcggaagat ggacagcata tgttcctgca ccctgtgaat gtgcgctgcc     2040

tcgtgcggga gtacggcagc ctggagagga gccccgagaa gatctcagca actgtggtgg     2100

agattgctgg ctactccatg tctgaggatg ttcgacagcg tcacagatat ctctctcact     2160

tgccactcac ctgtgagttc agcatctgtg aactggcttt gcaacctcct gtggtctcta     2220

aggaaaccct agagatgttc tcagatgaca ttgagaagag gaaacgtcag cgccaaaaga     2280

aggctcggga ggaacgccgc cgagagcgca ggattgagat agaggagaac aagaaacagg     2340

gcaagtaccc agaagtccac attcccctcg agaatctaca gcagtttcct gccttcaatt     2400

cttatacctg ctcctctgat tctgctttgg gtcccaccag caccgagggc catggggccc     2460

tctccatttc tcctctcagc agaagtccag gttcccatgc agactttctg ctgacccctc     2520

tgtcacccac tgccagtcag ggcagtccct cattctgcgt tgggagtctg gaagaagact     2580

ctcccttccc ttcctttgcc cagatgctga gggttggaaa agcaaaagca gatgtgtggc     2640

ccaaaactgc tccaaagaaa gatgagaaca gcttagttcc tcctgcccct gtggacagcg     2700

acggggagag tgataattca gaccgtgttc ctgtgcccag ttttcaaaat tccttcagcc     2760

aagctattga agcagccttc atgaaactgg acacaccagc tacttcagat cccctctctg     2820

aagagaaagg aggaaagaaa agaaaaaaac agaaacagaa gctcctgttc agcacctcag     2880

tcgtccacac caagtgacac tactggccca ggctaccttc tccatctggt ttttgttttt     2940

gttttttttt cccccatgct tttgtttggc tgctgtaatt tttaagtatt tgagtttgaa     3000

cagattagct ctggggggag ggggtttcca caatgtgagg gggaaccaag aaaattttaa     3060

atacagtgta ttttccagct tcctgtcttt acaccaaaat aaagtattga cacaagagat     3120

ctcttcctgc caaggttttt agttcattgc cagtttagtc tttttgaccc atgtgtaatt     3180

aatttttctc aacccaaagt aagattgagt cccctttgag atgcattaga gcagtccaac     3240

ccagaatggc acacactgct ctgctgtagc atcatgtcag ggcttcctgg actcagtaca     3300

cctctcagtt tgtcttttaa aaaacagctg aatctttact acctatttag ttctccttgt     3360

taaagaaaca ggggtgggaa taaaatggat ttaggacacc cagtttgaat tgcagttttt     3420

ttttttctga cacatggcca ggctgtggtg ccagcttaat ggagtaggct gtccttggca     3480

cttgcatgtg tgaaaggagg gttttgcctc ttcttgagca tggcttgagt tggtaaggaa     3540

agctgtaact cacgaagccc tgagacctgc tacccctaag atcgagcttg ttttcagtga     3600

ctggcttgag tcataggagg aggagtctgg tacagctgca ggagagcagg gccatctgaa     3660

gcggtagcat tgccaccatc tccctctcat ctagagcagt tttcttatgc cttggtttga     3720

gctgaatttg atgtgaattc ttttgctgct taataaagtg acctctaggt gcattagaat     3780

gcgaaggcaa atagttgcaa taaatcacct gcacaagcat tgtga                     3825


<210> 972
<211> 7697
<212> DNA
<213> Homo sapiens

<400> 972
agtgccctgg gacacctctt cagtccgtgg actttcccgc tgcacactgc cctccgaagt       60

cggggacgcg ggctcgtgag atggaagatt ttcgaggtat agcagaagaa tcatttccaa      120

gctttctcac caattcatta tttggtaaca gtgggatttt ggaaaatgtc actctttctt      180

caaatcttgg cttgcctgtt gctgtttcta cacttgctag ggatagatcc agcactgata      240

acaggtatcc tgatatccag gcatcttact tagtagaagg gagattttca gttccatccg      300

ggtcatctcc cggaagccag agtgatgctg aaccaagaga gaggttacag cttagcttcc      360

aggatgatga ttctatctct aggaaaaaga gctatgtgga aagtcaacgt ttgtcaaatg      420

ctctcagcaa acagtcagct ttacaaatgg agacagcagg accagaagag gagccagccg      480

gagctacaga atccttgcag ggccaagatc tcttcaacag ggcttcacca ctggaacaag      540

cacaagactc acctattgat tttcatttac agtcatggat gaataataag gaacccaaga      600

ttgttgtgct tgatgctgga aaacattttg aagacaagac tctaaagagt gacctaagcc      660

acactagctt attagaaaat gagaaactta tcttaccgac aagcttggaa gattcttctg      720

atgatgatat tgatgatgaa atgttttatg atgatcattt ggaggcttat tttgaacaac      780

tggcaattcc aggaatgata tatgaagacc tagaaggacc agaacctcca gaaaaaggtt      840

ttaagttacc tacaaatggt cttagacagg caaatgaaaa cggtagctta aactgcaagt      900

ttcaatcaga aaataacagc tctctgattt ccctcgactc acactcttct gaaacaactc      960

acaaagagtc tgaggaaagc caagttattt gtctacctgg gactagtaat tctataggta     1020

ctggagatag tagaaggtac acagatggta tgttaccatt ttcctctggt acttggggaa     1080

ctgagaaaga aatagaaaat ttgaagggta ttgttccaga tcttaacagt gaatgtgcaa     1140

gtaaagatgt tctggtgaag accctcaggg ctattgatgt gaaacttaac tctgataatt     1200

ttcatgatgc aaatgccaat agaggtggtt ttgatctgac tgaccctgta aaacaggggg     1260

cagagtgtcc tcaccaaaat aagacagttt tgcacatgga tggatgttta gacactgaga     1320

ctcctacggt gtccattcaa gaaaatgtgg atgtagcctc tttgaagccc attagtgaca     1380

gtggaattaa tttcactgat gccatttggt caccaacttg tgaaaggcga acatgtgaat     1440

gtcacgagtc catcgaaaag aataaagaca aaacagatct cccacagagt gtggtctatc     1500

aaaatgaaga gggtaggtgg gtcacagacc ttgcctatta cacatctttt aatagcaaac     1560

aaaatttaaa tgtgtctcta agtgatgaga tgaatgaaga cttcagatct ggttccatca     1620

tttggctatt ttattagatc accagagaag agagaaccta ttgccttaat aagaaaatct     1680

gatgtatcaa gaggtaattt ggaaaaagaa atggctcatc ttaaccatga tctatattca     1740

ggagatttaa atgaacagtc ccaggcacag ctaagtgaag gatcaattac acttcaggtt     1800

gaagcagtag agagtacttc acaagtggat gaaaatgatg tgacgttaac ggctgataaa     1860

ggcaaaacag aggacacttt cttcatgagc aacaaacccc aaagatacaa agacaagcta     1920

ccagatagtg gtgattctat gcttaggatc agcaccattg cttcagccat tgcagaggca     1980

tcagttaata ctgatccttc ccaacttgct gcaatgatca aggcactttc aaataaaacc     2040

agagacaaga cttttcagga agatgagaaa caaaaggact attctcatgt gcgtcatttc     2100

ttacctaatg atttagaaaa aagtaatgga tccaatgcac ttgatatgga gaaatacctt     2160

aaaaaaacag aagttagtag atatgaaagt gcattggaaa acttttcaag ggctagtatg     2220

tctgatactt gggatttatc tttgcccaaa gaacaaacta ctcaagacat tcatccggtg     2280

gacttaagtg ctactagtgt aagtgtgagg gcaccagaag aaaacacagc agctattgtt     2340

tatgttgaaa atggagagag tgagaatcaa gagtcattta gaaccataaa ctcctcaaat     2400

tcagttacaa atagagagaa taacagtgca gtagttgatg tgaagacatg ttccattgac     2460

aacaaattac aagatgttgg taacgatgaa aaagctacct caatttccac tccatctgat     2520

agttattcat cagtgaggaa ccccagaata acatcccttt gtctgttaaa agactgtgaa     2580

gaaatacgag ataacagaga aaatcagagg caaaatgagt gtgtcagtga aataagcaac     2640

agtgagaagc atgtgacttt tgaaaaccat cgcatagtct cacctaaaaa tagtgatttg     2700

aaaaatacct ctcctgagca tggtggacgt ggctcagagg atgagcagga gagcttcaga     2760

ccttccacgt caccactgag tcattcttct cctagtgaaa tttctggaac gagttcatca     2820

gggtgtgcgt tagagtcctt tggttcagca gctcagcagc agcagcctcc ctgtgagcag     2880

gagttgtctc ccttggtgtg ctcgcctgct ggggtgagca ggctgacgta tgtgtctgaa     2940

ccagagagct cctatcctac cacagccaca gatgatgccc tggaggaccg caagagtgat     3000

atcaccagcg agttgagtac cacaattatt caaggcagtc cagccgcatt ggaggaacgg     3060

gctatggaaa aattgagaga aaaagttcca tttcagaata gaggaaaagg aacattatca     3120

tctattatcc agaataactc tgatacaaga aaagcaactg aaactacttc tctgagtagc     3180

aagcctgaat atgtaaaacc tgactttaga tggagtaaag atccttcctc caaaagtgga     3240

aatctgttgg aaaccagtga ggtaggttgg acatcaaacc ctgaggaatt ggacccgatc     3300

aggctggctc tcctgggcaa gtcaggtctg agctgtcagg tggggtcagc cacatcacac     3360

cctgtgtcct gccaggagcc tatagatgaa gatcaaagaa taagtcctaa agataagtca     3420

actgctggcc gtgagttcag tggccaggtt tctcatcaga ccacctctga aaaccagtgt     3480

actcctattc ccagcagcac agttcacagc tctgtggctg acatgcagaa catgcctgct     3540

gctgtgcacg cactcttgac acaaccctct ctcagcgctg ctccttttgc tcagcggtat     3600

ttgggaacac tcccttcaac tggaagcacc accttgcctc agtgccatgc tggcaatgcc     3660

acagtctgtg gcttctcagg aggccttccc tatccagctg ttgcaggaga gcctgtgcag     3720

aactctgtgg ctgtgggaat ttgtctagga tcaaatatcg gctctggatg gatgggtacc     3780

tcttccctct gtaacccata ttctaatacc ttaaatcaga acctgctaag cacaacaaaa     3840

ccttttcctg tgccgtctgt tggtacaaac tgtggaattg aaccatggga ttcaggagtg     3900

acatcaggat tggggagtgt ccgagtgccc gaggagttga agcttcctca tgcttgctgt     3960

gtcgggatcg cttcccagac cctcctcagt gtgcttaatc caactgaccg ctggctgcaa     4020

gtcagcattg gggtcctcag cattagtgtt aatggtgaaa aggtggatct ttcaacatat     4080

cgttgtttag ttttcaagaa taaagccatc ataagacctc atgccacaga agagataaaa     4140

gtgcttttta taccatccag tcctggggtt ttcagatgca cattcagtgt tgcttcttgg     4200

ccatgttcga cagatgctga gaccatcgta caggcagaag ctttggccag caccgtcact     4260

ctcactgcca ttgccgagag tcctgttatt gaggtagaaa cagaaaagaa agacgttctt     4320

gattttggtg acttgactta tggaggctgg aaagccctcc cactaaaatt gataaaccga     4380

acgcatgcca ctgtgccaat tagactgatt attaatgcta acgctgtagc ctggcgctgt     4440

ttcacgtttt ccaaggaatc cgtccgagct cctgtggaag ttgctccttg cgctgatgtg     4500

gtcactcggc tagcaggccc ttctgtggtc aaccacatga tgcctgctag ttatgatgga     4560

caggatccag aatttctgat gatttgggtt cttttccata gtccaaagaa acagatcagc     4620

tcttcagata ttctggactc agcagaagaa ttctcggcaa aagttgatat cgaagttgac     4680

agcccaaacc ctacgcccgt tcttagaagt gtgagtctcc gagcaagagc aggaatagct     4740

aggatccatg ctcccaggga cttgcagacg atgcatttct tggccaaagt ggcttcctca     4800

agaaagcagc acttaccttt gaaaaatgct gggaacattg aagtttattt ggatatcaag     4860

gtcccagaac aaggaagtca cttttcagtg gatccaaaga atctactcct taaacctgga     4920

gaagaacatg aggttattgt ttcatttact ccaaaggatc ctgaagcctg cgaggaaagg     4980

atcttgaaaa tatttgtgca gccatttgga cctcagtatg aggtagtgtt aaaaggcgaa     5040

gtcatttctt caggaagtaa acctctgtca cctggacctt gcttagatat tccatcgatt     5100

ttgtccaaca aacaatttct ggcttgggga ggagtccctc taggtagaac acagcttcag     5160

aaactagctt taagaaataa ttctgcatct acaactcaac atttacgact gcttattaga     5220

ggacaagatc aggactgctt tcagcttcag aacacttttg gttcagaaca gcgattgacc     5280

agtaactgtg agatcagaat tcacccaaag gaagacattt tcatctctgt attatttgca     5340

cctactcgat tatcttgcat gttggctaga ctagaaatca aacaacttgg aaatcgatca     5400

caaccaggca ttaagttcac aatacctttg tctggatatg gaggaacaag caatcttatt     5460

ttggaaggcg ttaaaaaatt atctgacagt tacatggtaa cagtgaatgg cttagtacct     5520

ggcaaagaaa gtaaaattgt tttttctgtc cgcaacactg gctcccgagc agcttttgtt     5580

aaagcagtag gttttaagga ttctcagaaa aaagttttgc tggatcctaa agtattgagg     5640

atttttccag ataaatttgt actcaaggaa agaacacaag aaaatgttac tttaatatat     5700

aatccatcag acagaggaat caataataaa actgcaacag aactatcaac tgtatactta     5760

tttggtggag atgaaatttc aagacagcag tatcgcaggg ccctgttaca taaaccagag     5820

atgataaaac agatacttcc agaacatagt gtgcttcaaa acattaattt tgttgaagca     5880

tttcaagatg agctattagt aactgaagta tatgatcttc cccaacgacc taatgatgtt     5940

cagctctttt atggaagcat gtgtaaaatt atactttcag taattggaga attcagagat     6000

tgcatttcta gcagagaatt ccttcagcct tcttccaaag ctagcttgga atctacaagc     6060

gacttgggag cttctgggaa acatggtggc aacgtctctt tggatgtttt accagtcaaa     6120

ggtcctcagg gttctcctct tctctcacgg gcggctcgcc cgcctctgga tcagctggcc     6180

tccgaagagc cgtggactgt cctacccgag cacttgattc tggtagctcc ttctccttgt     6240

gacatggcaa aaactggacg tttccagatt gtgaataact ctgtgaggtt actgagattt     6300

gagctgtgct ggccagcgca ttgcctcaca gtcacgccgc agcatggatg tgtcgcgcca     6360

gagagtaaac tacaaattct tgtgagtcct aattcctcct tatccacaaa acagtcaatg     6420

ttcccgtgga gtggtttgat ctatatacac tgtgacgatg gacagaagaa aattgtgaaa     6480

gttcaaattc gagaagattt aactcaagtg gaacttttaa ctcgtttgac ctccaaacca     6540

tttggaattc tttccccagt atctgagcct tcagttagtc atttggtcaa accaatgaca     6600

aaaccgcctt ccacaaaagt tgaaataaga aacaagagta ttacttttcc tacaacagaa     6660

cctggtgaaa cttcagagag ctgtctagaa ctcgagaatc atggcaccac agacgtgaaa     6720

tggcatctgt catctttagc gccaccttat gtcaagggag ttgatgaaag tggagatgtt     6780

tttagagcta cctatgcagc attcagatgt tctcctattt ctggtctgct ggaaagccat     6840

gggatccaaa aagtctccat cacatttttg cccagaggta ggggggatta tgcccagttt     6900

tgggatgttg aatgtcaccc tcttaaggag cctcacatga aacacacgtt gagattccaa     6960

ctctctggac aaagcatcga agcagaaaat gagcctgaaa acgcatgcct ttccacggat     7020

tccctcatta aaatagatca tttagttaag ccccgaagac aagctgtgtc agaggcttct     7080

gctcgcatac ctgagcagct tgatgtgact gctcgtggag tttatgcccc agaggatgtg     7140

tacaggttcc ggccgactag tgtgggggaa tcacggacac ttaaagtcaa tctgcgaaat     7200

aattctttta ttacacactc actgaagttt ttgagtccca gagagccatt ctatgtcaaa     7260

cattccaagt actctttgag agcccagcat tacatcaaca tgcccgtgca gttcaaaccg     7320

aagtccgcag gcaaatttga agctttgctt gtcattcaaa cagatgaagg caagagtatt     7380

gctattcgac taattggtga agctcttgga aaaaattaac tagaatacat ttttgtgtaa     7440

agtaaattac ataagttgta ttttgttaac tttatctttc tacactacaa ttatgctttt     7500

gtatatatat tttgtatgat ggatatctat aattgtagat tttgttttta caagctaata     7560

ctgaagactc gactgaaata ttatgtatct agcccatagt attgtactta acttttacag     7620

gtgagaagag agttctgtgt ttgcattgat tatgatattc tgaataaata tggaatatat     7680

tttaatgtgg tatatcc                                                    7697


<210> 973
<211> 4842
<212> DNA
<213> Homo sapiens

<400> 973
gcggcctcca tgcgggcgtc aacgtccgat ccaagcgcca aattcaaatt tgcggccatc       60

ttgagcgggc ggaattcagt cgcgcgcggt gcagtcggga ggtggaggca ccggctgcat      120

tgttttcggg atcgaggggt gagggcgcta tggcacccgg ctgcaaaact gagttacgca      180

gcgtgacaaa tggtcagtct aaccaaccaa gtaatgaagg tgatgccatc aaagtttttg      240

tgcgaattcg tcctcctgca gaaagatctg ggtcagctga tggagagcag aacttatgct      300

tatctgtgct gtcctccacg agtctccggc tgcactccaa ccctgagccc aagaccttca      360

cgtttgatca tgttgcagat gtggatacca ctcaggaatc tgtattcgca actgtggcta      420

aaagcattgt ggagtcttgc atgagcggtt ataatggtac catctttgca tatggacaga      480

ctggctcagg gaagacattt actatgatgg gaccatctga atctgataat ttttctcata      540

acctgagagg agtaatccca cgaagttttg aatatttgtt ttccttaatt gatcgtgaaa      600

aagaaaaggc tggagctgga aagagtttcc tttgtaagtg ttcctttatt gaaatctaca      660

acgagcagat atatgatcta ctggactctg catcggctgg actgtactta agggagcata      720

tcaagaaggg agtctttgtt gttggtgcgg tggagcaggt ggtaacctca gctgctgaag      780

cctatcaggt gttgtctgga ggatggagga atagacgtgt ggcatcaaca tcaatgaaca      840

gagaatcgtc taggtctcat gccgtcttta caattacaat agagtcaatg gagaaaagta      900

atgagattgt gaatatacgg acctccctac tcaacctggt ggatttagca ggatctgaaa      960

ggcaaaaaga tacccatgca gaagggatga gattgaagga agcaggtaac ataaatcgat     1020

cattgagctg cctgggccaa gtgattacag cacttgtcga cgtgggtaat ggaaaacaga     1080

gacatgtttg ctacagagac tccaaactta ccttcttact acgggattcc cttggaggta     1140

atgccaaaac agccataatt gcaaatgttc atcctggatc caggtgtttt ggggaaaccc     1200

tatcaacact taactttgct caaagagcca agctgattaa aaacaaggca gtagtaaatg     1260

aagacaccca aggaaatgtg agccagctcc aagctgaagt gaagaggctc aaagaacaac     1320

tggcggagct tgcttcagga cagacaccac cagaaagctt cctgaccaga gacaaaaaga     1380

agactaacta tatggagtat ttccaggaag caatgttatt ctttaagaaa tctgaacagg     1440

aaaagaagtc tctgatagaa aaagttaccc aattagaaga cctcaccctc aaaaaggaaa     1500

aatttattca atctaataaa atgattgtga aattccgaga ggatcaaata atacgcttgg     1560

aaaagctcca caaggaatcc cggggaggtt ttctgcctga ggagcaggat cgtttgctct     1620

cagaattaag gaatgagatt caaactctgc gagaacaaat agagcaccac cccagagttg     1680

caaagtatgc tatggaaaat cattccctca gggaggagaa tagaagactg agattattag     1740

agcctgtgaa aagagctcaa gaaatggatg cccagaccat tgcaaaacta gaaaaagctt     1800

tctctgaaat aagtggcatg gagaaaagtg acaaaaatca gcaaggattt tcacctaaag     1860

ctcagaaaga gccatgtttg tttgcaaaca ctgagaagtt aaaagcacaa ctcctgcaaa     1920

ttcagacaga gctgaataat tcaaagcaag aatatgaaga attcaaagaa cttactagga     1980

aaaggcagct agaattggaa tcagagcttc agtctttgca aaaagcgaac cttaatcttg     2040

aaaacctttt ggaagcaaca aaagcctgca agcggcaaga agtttctcag ctgaataaaa     2100

ttcatgctga aacacttaag attataacta caccaaccaa ggcctaccaa cttcattccc     2160

gaccagtacc aaaattaagc cctgaaatgg gaagctttgg ctctctatac actcagaatt     2220

ctagcatatt agataatgat atattaaatg agccagttcc tcctgagatg aatgaacaag     2280

cttttgaggc catttctgaa gagcttagaa cagtgcagga acaaatgagt gctcttcaag     2340

ccaaactgga tgaagaagag cataaaaacc taaagcttca gcagcatgtt gacaaactgg     2400

aacatcattc tacccaaatg caggagcttt tctcatcaga aagaattgat tggaccaaac     2460

agcaggaaga gcttctctca cagttgaatg tccttgaaaa gcagcttcaa gagactcaaa     2520

ctaaaaatga ctttttgaaa agtgaggtac atgacctgcg agtagtcctt cattctgctg     2580

acaaggagct ttcttcagtg aaattggaat atagttcatt caaaacgaat caggagaaag     2640

aattcaacaa actttccgaa agacacatgc atgtacagct tcaattagat aatctcaggt     2700

tagaaaacga aaagctgctt gagagcaaag cctgcctaca ggattcctat gacaacttac     2760

aagaaataat gaaatttgag attgaccaac tttcaagaaa cctccaaaac ttcaaaaaag     2820

aaaatgaaac tctgaaatct gatctgaata atttgatgga gcttcttgag gcagaaaaag     2880

aacgcaataa caaattatca ttacagtttg aagaagataa agaaaacagt tctaaagaaa     2940

tcttaaaagt tcttgaggct gtacgtcagg agaaacagaa agagacggcc aagtgtgagc     3000

agcagatggc aaaagtacag aaactagaag agagcttgct tgctactgaa aaagtgatca     3060

gttccctgga aaagtctaga gattctgata agaaagttgt agctgacctc atgaaccaga     3120

tccaggagct aagaacatcg gtctgtgaga aaacagaaac tatagacacc ctgaaacaag     3180

aactgaagga cataaattgc aaatacaact ctgctttggt tgacagagaa gagagcagag     3240

tgttgatcaa gaagcaggaa gtggatattc tggatctgaa agaaaccctt aggctgagaa     3300

tactttctga ggacatagag agggatatgc tctgtgagga cctggctcat gccactgagc     3360

agctgaacat gctcacagag gcctcaaaaa aacactcggg gctgctgcag tctgcccagg     3420

aagaactgac caagaaggaa gccctgattc aggaacttca gcacaagcta aaccaaaaga     3480

aagaggaagt agaacagaag aagaatgaat ataacttcaa aatgaggcaa ctagaacatg     3540

tgatggattc tgctgctgag gatccccaga gtcctaagac accacctcac tttcaaacac     3600

atttggcaaa actcctggaa acacaagaac aagagataga agatggaaga gcctctaaga     3660

cttctttgga acaccttgta acaaagctaa atgaagacag agaagtcaaa aatgctgaaa     3720

tcctcagaat gaaggagcag ttgcgtgaaa tggaaaacct acgcctggaa agtcagcagt     3780

taatagagaa aaactggctc ctgcaaggtc agctggatga tattaaaaga caaaaggaaa     3840

acagtgatca gaatcatcca gataatcaac agctgaagaa tgaacaagaa gaaagtatca     3900

aagaaagact tgcaaaaagt aaaatagttg aagaaatgct gaaaatgaaa gcagacctag     3960

aagaagtcca aagtgccctt tacaacaaag agatggaatg ccttagaatg actgatgaag     4020

tcgaacgaac ccaaactttg gagtctaaag cattccagga aaaagaacaa ctgagatcaa     4080

agctggaaga aatgtatgaa gaaagagaga gaacatccca ggagatggaa atgttaagga     4140

agcaggtgga gtgtcttgct gaggaaaatg gaaagttggt aggtcaccaa aatttgcatc     4200

agaagattca gtacgtagtg cgactaaaga aggaaaatgt caggcttgct gaggagacag     4260

aaaagttgcg tgccgaaaat gtatttttaa aagaaaagaa aagaagtgaa tcttgaggat     4320

tccggtcagc tacctaggca tcaccttgtt tgaagatgtt tcttctcttt tacaagtaag     4380

acctactcct ggccacttag gagagctgaa tttatggacc ttaattatta aatgtttata     4440

aggtggtggt aaccacctca agtttctgat gaacattctg catccatata caccctgtga     4500

cagtcagcag tctgctatta agtggcctac ttcaaggctt tgaatcaact taagggaaaa     4560

ccttttgtct ttgtaaaaat aaaagcctgt agctaaggtt tacagtggac attagccaga     4620

tcattttctt cttagattat gccataatct cctttgattc ttatggaagt tctaacaata     4680

tatggtggtt ccaacacctg cagtgagttt aatgactgac ttagtagcag gtacaagaag     4740

caaacttgtt aatatagatt atttttgtat tcttacttta ggtattttct tgagcatttt     4800

ccatgactgt aaataaagcc attttttaag ataataatta aa                        4842


<210> 974
<211> 8723
<212> DNA
<213> Homo sapiens

<400> 974
gtttgggagg cgcgggagat gtccaccctg ggctggtggc gccgccgggc gccgggcgcc       60

atgagggtgc gctaggcggc tgttcgtgcc cgaggctgcg cagcactgag gtgagctttg      120

ccttcttgat cttccgtcct tcttggagac gactggcgag aggaagaggg actaggtcca      180

aacgctaggt ggctgggtcc agatacctgt gttttgactc tgttcctgtg gatagctgct      240

tggtctgaag ttccagaaag gatcctgttc ccagacaggt ccctgagtac tgacggtcac      300

aggctgccgc gtctttcctg ttgactcatg tttggttcct ccagtgaaaa ttttacttag      360

agaaatgctg cctccaaagc acttgtctgc caccaaacct aagaagtcct gggccccaaa      420

tctgtatgag ctagacagtg acttgactaa ggagccggat gtcatcatag gagaaggtcc      480

aactgactct gagttttttc atcagaggtt tcggaaccta atctatgtgg aatttgttgg      540

gcctcggaag accctgatca aactccgaaa cctctgcctc gattggttgc agccggagac      600

ccgcaccaag gaggagatca tcgagctctt ggtccttgag cagtacctga ccatcatccc      660

tgaaaagctc aagccttggg tgcgagcaaa aaagccggag aactgtgaga agctcgtcac      720

tctgctggag aattacaagg agatgtacca accagaagac gacaacaaca gtgacgtgac      780

cagcgacgac gacatgaccc ggaacagaag agagtcctca ccacctcact cagtccattc      840

tttcagtgac cgggactggg accggagggg cagaagcaga gacatggagc cacgagaccg      900

ctggtcccac accaggaacc caagaagcag gatgcctccg cgggatcttt cccttcctgt      960

ggtggcgaaa acaagctttg aaatggacag agaggacgac agggactcca gggcttatga     1020

gtcccgatct caggatgctg aatcatacca aaatgtggtg gacctcgctg aggacaggaa     1080

acctcacaac acaatccagg acaacatgga aaactacagg aagctgctct ccctcgtgca     1140

gcttgctgaa gacgatggcc actcccacat gacgcagggc cactcatcaa gatccaagag     1200

aagtgcctac ccaagcacca gtcgaggtct aaaaactatg cctgaagcca aaaaatcaac     1260

ccaccggcgg gggatttgtg aagatgaatc ttcccacgga gtgataatgg aaaaattcat     1320

caaggatgtg tcacgcagtt ccaaatcggg aagagcaagg gagtcaagcg accggtcaca     1380

gagattcccc agaatgtcag atgataactg gaaggacatt tcattgaaca agagggagtc     1440

agtgatccag cagcgggttt atgaagggaa tgcatttagg ggaggcttta ggtttaattc     1500

aacccttgtt tccagaaaga gagttcttga aagaaagagg cgctatcatt ttgacacaga     1560

tgggaagggc tcgattcacg atcaaaaagg ctgtcccagg aagaagccct ttgaatgtgg     1620

tagtgagatg agaaaagcca tgagcgtgag cagcctgagc agcctcagct ccccctcctt     1680

taccgagtca cagccaattg attttggggc aatgccatat gtatgtgatg agtgtgggag     1740

gtcgttcagt gtcatctcag aatttgttga gcaccagatc atgcatacta gagagaacct     1800

ctatgagtat ggtgagtcct ttatccacag tgtggctgtc agtgaagttc agaaaagtca     1860

ggttggaggg aaacgttttg aatgtaagga ctgtggagag accttcaata agagtgccgc     1920

cttggctgaa catcggaaga ttcatgctag aggttatctt gtggaatgta agaatcagga     1980

atgtgaggaa gccttcatgc ctagccccac ctttagtgag cttcagaaaa tatatggcaa     2040

agacaaattc tacgagtgca gggtgtgtaa ggaaaccttc cttcatagtt ctgccctgat     2100

tgagcaccag aaaatccact ttggggatga caaagataat gagcgtgaac atgaacgtga     2160

acgtgaacgt gagcgcgggg aaacctttag gcccagccca gcccttaatg agtttcagaa     2220

aatgtatggt aaagagaaaa tgtacgaatg taaggtgtgt ggggagactt tccttcatag     2280

ctcatccctg aaagaacatc agaaaatcca tactagaggg aacccatttg aaaacaaggg     2340

taaagtgtgt gaggaaacct ttattcctgg tcagtccctt aaaaggcgtc agaaaactta     2400

caataaggag aagctctgtg actttacaga tggccgggat gccttcatgc aaagctcaga     2460

gctcagtgag catcagaaaa ttcattctcg aaagaacctc tttgaaggca gagggtatga     2520

gaaatctgtc attcatagtg ggccattcac tgaatctcag aagagtcata ctataacaag     2580

acctcttgaa agtgatgagg acgaaaaggc gttcaccatt agctctaacc cctatgaaaa     2640

ccagaagatt cccactaagg aaaatgtcta tgaggcaaaa tcatatgaga ggtctgttat     2700

tcatagctta gcctctgtgg aagctcagaa aagtcacagt gtagcagggc ccagtaaacc     2760

aaaagtaatg gcagagtcta ccattcagag cttcgatgct atcaaccatc agagagttcg     2820

tgctggaggg aacacctctg aaggaaggga atacagtagg tctgttatcc atagcttagt     2880

ggcttccaaa cctccaagaa gtcacaatgg aaatgaattg gtggaatcta atgagaaggg     2940

agaatcctcc atttatatct cagaccttaa tgataagcga cagaagattc ctgccagaga     3000

gaacccttgt gaagggggca gtaagaatcg caactatgaa gactctgtca tacagagtgt     3060

attccgtgcc aaacctcaga aaagtgttcc tggagaggga tctggtgagt ttaagaagga     3120

tggcgaattc tctgttccca gctcaaatgt ccgtgaatac cagaaggctc gtgctaaaaa     3180

gaaatacatt gagcatagga gcaatgagac ctctgtaatt cactctctgc cttttggtga     3240

acaaacattt cgccctcgag ggatgctcta tgaatgtcag gagtgtgggg agtgctttgc     3300

tcatagctct gacctcactg agcaccagaa gattcatgat agggagaagc cctctggaag     3360

cagaaactat gaatggtctg tcattcgcag cttggcccct actgaccctc aaacaagtta     3420

cgcccaagag cagtatgcta aagagcaagc gcggaacaaa tgtaaggact tcagacaatt     3480

ttttgctacc agcgaagacc tcaacacaaa ccagaaaatc tatgaccaag agaagtctca     3540

tggcgaggag tctcaaggcg agaatactga tggggaggag acccacagcg aggagaccca     3600

tggtcaggag acaattgaag accctgtcat tcaaggctca gacatggaag accctcagaa     3660

ggatgaccct gatgacaaaa tctatgaatg tgaggactgt ggcctgggct ttgtggatct     3720

cacagacctc acagaccatc agaaagtcca cagcaggaag tgcctggttg acagtcggga     3780

gtacacacat tctgtaattc acacccattc catcagcgag tatcagagag attacactgg     3840

agagcagctg tatgaatgtc caaagtgtgg ggaatctttt attcatagct cattcctttt     3900

cgagcatcag agaatccatg aacaagacca gttgtattcc atgaaggggt gtgatgatgg     3960

ttttattgcc ctcttgccca tgaagccacg gaggaatcgt gctgcagaga ggaatcctgc     4020

tcttgctggg tcggccattc gatgcctttt gtgtggacaa ggcttcattc atagctctgc     4080

ccttaatgag catatgagac ttcataggga agatgattta ctggagcaga gccagatggc     4140

tgaggaagct atcattccag gcttagccct cactgagttt cagagaagtc agaccgaaga     4200

gagactcttt gaatgtgcag tctgtggaga atctttcgtc aacccagcag aacttgcaga     4260

tcacgtaact gttcataaga atgagcccta tgagtacggg tcctcctata ctcacacctc     4320

atttcttact gagcccctca aaggagctat accattctat gaatgcaagg attgtggtaa     4380

gtcctttatt catagcacag tcctcactaa acataaggag cttcatctgg aagaagaaga     4440

agaagatgaa gcagcagcag ctgcagcagc agcagcccag gaagttgaag ccaatgtcca     4500

tgttccacaa gtagttctga ggattcaggg cttaaacgta gaggctgctg agccagaagt     4560

ggaggctgcc gagccagaag tggaggctgc tgagccagaa gtggaggctg ctgagccaaa     4620

cggagaggct gaagggccag atggagaggc tgcagagccc attggagagg ctggacagcc     4680

aaatggagag gccgagcagc caaatgggga tgctgatgag ccagatggtg caggtattga     4740

agacccagaa gaaagagctg aagagccaga gggaaaagct gaagagccag agggagatgc     4800

cgacgagcct gacggtgtgg gaattgaaga cccagaagaa ggtgaagatc aagagattca     4860

ggtagaagaa ccatactatg actgccatga atgcacagaa accttcactt ccagcacagc     4920

attcagtgaa cacctgaaaa ctcatgccag catgatcata tttgagcctg caaatgcctt     4980

tggggagtgc tcaggctaca tcgaacgtgc cagcaccagc acaggtggtg ccaatcaagc     5040

tgatgagaag tacttcaaat gtgacgtctg tgggcagctc ttcaatgacc gcctgtccct     5100

cgccagacac cagaataccc acactggctg agggcatggg gtaaaggtta gaaaaccttc     5160

acctaggact tgacccttac caaaccacag agaatccaaa ccaatccatg ataatgtcag     5220

taggagactt aaccttagtg tgttacacac ctgacttaac atctctaaac tcagattgaa     5280

aagagaccga atgtgcagat tccacagtct taagctttcc ccttcagatg tcagtgtctg     5340

catgtgggaa agccatagca cacatcttac ctttccaagt aatcagattg agaaaaccct     5400

atgagtattc cagactacag agtttgccca aatcaactgt aaatgacact tgtgtaacgt     5460

atatatagtg tttcatgagg tgtatataaa atagcaaatt atgacagaac agtgatcaca     5520

tatatttgga tttatatgat atacagttac agtttactct gcagaggtac cttacctggt     5580

attctttgaa tttttttttt ttttggagga ggaagagagc aacaaatttg attatatttt     5640

taagtgtctt agatcctgag aaagatttat tgtgcattat ttgaaccctg tcaatatctt     5700

tttgagtaat tgttttgttt cttaccctta aatagtcttg tgaagctgta ggcatgatag     5760

ataacatggc ttttactcct tactgtttga aaagataagt actttagctt ctttctgcag     5820

ccatttcatc tgcgccaaca ctttggaacc taatactgtg taaggcttta caatatacgg     5880

attggctttt tgtgacccag attgattggt tgccacatgt tatgtttgtt gaagtggttc     5940

tcatgcaaaa atattacaca tttgtgttct gggttttttt tttttttaac caactcaata     6000

tgtgtttgat gatagtgaat tgataaaacc cgaagctttt ccctgtaaat cttacatctt     6060

tgcctttaaa gaatgggtta caaccatcac tagatcacag tagtgcctaa tgaaggttga     6120

gaaccgtagg agaggctctc atgctgtaaa taatgttgca ggctaataac ctttcatcac     6180

ttcctttgtg cgcttcctgc cttaagtgac aagtagcaac atggcttggg tcccctgtgc     6240

agcatcagct tatgctgcca caagtcagtt tgcaccctag gtgcccagga gctagtatcc     6300

ttagatcttt ctatcgctaa cttaattctc ttcgttattt atctgaccct ctaactccat     6360

gtctaacttg cattaaaaaa aaaaaaattc tttacagtca acccaagctt aacatggact     6420

caggttcccc agcagcctta atttgttttg ttaacatctg ttccttcttt ttcagctctc     6480

ctagagtatt tctgagtgtt gtgttcatct aatcttagta ttcttttaat tacaaattga     6540

cctcacagct tgaggtttct tgtgtcctat tctgtggact acctgtgctc ctttgcttcc     6600

cctcccctcg cataataact atattaagaa attttttttg gccttgagtt ggctggaaaa     6660

aaaatataaa atttaaaaaa tttaaaaaaa aagatttgca aaatgtaagt gtagatcatt     6720

tgaacaagca aaattaaagt acccactggg ggaaatgtgt ctgaatctta ctcttctgga     6780

tctgcaggat tagggcttgg aagtatgtca aagatgcagg gagtgtcaaa gtttaggaag     6840

attgtagagc tgagagcaag aagcagaaat gagtgagtca aagaagggag tcctaatata     6900

tcaccagatc taggagggga gaggagacag acagaagaaa acaccagagg caagaactgt     6960

agaaggccag gtttctgaga atgaattgag cggggtgtcc tgagcagttt ggaaaaggag     7020

tttttgatgg tatggtgtag gtgagggctg gctgcatagg aaggactgag gttggaacgg     7080

acatcgggaa agctgagggg cagtgaggtt tactacatgg gaaaaggact cttgaaacga     7140

gaatcagtgt tgatgtcggg gtgaactttg tgggtacatt acttggtgtt aacattgttg     7200

gcagtggtag ccccttttca gaaagcaact tgctgtaagt cagggtgtcc gttccaacct     7260

tcagctagtg aaaaggtagt aacaaatggt aaacaagaga atgattgttt aaacctatct     7320

gtggacactt aatgcaactg tttaaaaatg ataatcacga gttatgtagc aacgtggaaa     7380

tatatttaca gaacattaag tggagaaagc aggacacgaa agtatattta tactacagtt     7440

ataactcaac agttcattta tatgctgttc atttaacagt tcatttaaac agttcattat     7500

aactgtttaa aaatatatat gcttatagtc aaaagctgtt gtggtgttgt tgttgtaggc     7560

ttatagttga gcattatttt cttaaatttc ttgaatgttc tttatggtag tgttactaaa     7620

aagtttatga tcacattttc attgtgaaca taatttgaac tcattatcac acacttggaa     7680

aatacagaaa agtggaggaa aaaaaatcat atccccacca tccaaagaca tatactctcc     7740

tcttatcttg ttcattcttg tttctgtgca caggtttatg attataactg tgtcaaaatg     7800

tatattcaaa atagctgtta cattaccttt gtggaattat ggttaaatac tttcacttta     7860

attttttcaa atgttcccta taataatgtc ctgataacag tgtattatgt gtgtctccat     7920

tggtgtgcat aatacatacc cagaggaaaa attagaaaat aaagtaaatt attttaaaaa     7980

attacctata ttcccaacac ctaacaacta ctgctaacat cttgatctgt ttcctctatc     8040

ttgtttcagt gcacacgctt gtgataacag tgttaaatat gtgtgcataa agtcttaaat     8100

gaaaagatgt ggaaaataac taaaatagtg ttgtcattgt gggaatttgg ttaaatattt     8160

tgtctcaaat tccttaaata atctttggtg ttttggtaat aaattttatg tatgtatttt     8220

ccattacaaa tataatacat actcatacaa aactttggaa attcagtaaa gaaaattcac     8280

acatattccc aacacccaac aacaattaac tgttaacatc ttgatctgtg cactagtctg     8340

tgattattag ggtgttagtg ataagtatgc ataaatgtca aagatgggaa gaaagatgaa     8400

aaacaagaaa tagttgtgtg gttgttgtgg gattatggtt attttgtttc ggtttccttg     8460

aaaggtcatc attctagtgt tttggtagtc cacctttact acatatattt ccattatata     8520

tgaaatgtgt tcattataga aactttgaag ttacagaaat gtagaagaga aactcaccca     8580

tgttttcacc atccaaagag tgtggttaac atcttgatat attttcttca tcttgtttct     8640

gtgcacaggt ttttggtttg ttaatatggt tgtggtcatt ctatctgtaa tagtgtcaac     8700

aataaaaata aagttaaaaa taa                                             8723


<210> 975
<211> 3001
<212> DNA
<213> Homo sapiens

<400> 975
aatcttataa cttgaagaac tgccctggag aaaggaagaa acttataata aatgggaaat       60

tataaatcta gaccaaccca aacttgtact gatgaatgga agaaaaaagt cagtgaatca      120

tatgttatca caatagaaag attagaagat gacctgcaga tcaaggaaaa agaactgaca      180

gaactaagga atatatttgg ctctgatgaa gccttcagta aagtcaattt aaattaccgc      240

actgaaaatg ggctgtctct acttcattta tgttgcattt gtggaggcaa gaaatcacat      300

attcgaactc ttatgttgaa agggctccgc ccatctcgac tgacaagaaa tggatttaca      360

gccttgcatt tagcagttta caaggataat gcagaattga tcacttctct gcttcacagt      420

ggagctgata tacagcaggt tggatacggt ggcctcactg ccctccatat tgctacaata      480

gctggccacc tagaggctgc tgatgtgctg ttgcaacatg gagctaatgt caatattcaa      540

gatgcagttt ttttcactcc attgcatatt gcagcgtact atggacatga acaggtaact      600

cgccttcttt tgaaatttgg tgctgatgta aatgtaagtg gtgaagttgg agatagaccc      660

ctccacctag catctgcaaa aggattcttg aatattgcaa aactcttgat ggaagaaggc      720

agcaaagcag atgtgaatgc tcaagataat gaagaccatg tcccactcca tttctgttct      780

cgatttggac accatgatat agttaagtat ctgctgcaaa gtgatttgga agttcaacct      840

catgttgtta atatctatgg agataccccc ttacacctgg catgctacaa tggcaaattt      900

gaagttgcca aggaaatcat ccaaatatca ggaacagaaa gtctgactaa ggaaaacatc      960

ttcagtgaaa cagcttttca tagtgcttgt acctatggca agagcattga cctagtcaaa     1020

tttcttcttg atcagaatgt cataaacatc aaccaccaag gaagggatgg gcacactgga     1080

ttacactctg cttgctacca cggtcacatt cgcctggttc agttcttact ggataatgga     1140

gctgatatga atctagtggc ttgtgatccc agcaggtcta gtggtgaaaa agatgagcag     1200

acatgtttga tgtgggctta tgaaaaaggg catgatgcca ttgtcacact cctgaagcat     1260

tataagagac cacaagatga attgccctgt aatgaatatt ctcagcctgg aggagatggc     1320

tcctatgtgt ctgttccatc acccttgggg aagattaaaa gcatgacaaa agagaaggca     1380

gatattctcc tcctaagagc tggattgcct tcacatttcc atcttcagct ctcagaaatt     1440

gagttccatg agattattgg ctcaggttct tttgggaaag tatataaagg acgatgcaga     1500

aataaaatag tggctataaa acgttatcga gccaatacct actgctccaa gtcagatgtg     1560

gatatgtttt gccgagaggt gtccattctc tgccagctca atcatccctg cgtaattcag     1620

tttgtgggtg cttgcttgaa tgatcccagc cagtttgcca ttgtcactca atacatatca     1680

gggggttctc tgttctccct ccttcatgag cagaagagga ttcttgattt gcagtctaaa     1740

ttaattattg cagtagatgt tgccaaaggc atggagtacc ttcacaacct gacacagcca     1800

attatacatc gtgacttgaa cagtcacaat attcttctct atgaggatgg gcatgctgtg     1860

gtggcagatt ttggagaatc aagatttcta cagtctctgg atgaagacaa catgacaaaa     1920

caacctggga acctccgttg gatggctcct gaggtgttca cgcagtgcac tcggtacacc     1980

atcaaagcag atgtcttcag ctatgctctg tgtctgtggg aaattctcac tggcgaaatt     2040

ccattcgctc atctcaagcc agcggctgcg gcagcagaca tggcttacca ccacatcaga     2100

cctcccattg gctattccat tcccaagccc atatcatctc tgctgatacg agggtggaac     2160

gcatgtcctg aaggaagacc cgaattttct gaagttgtca tgaagttaga agagtgtctc     2220

tgcaacattg agctgatgtc tcctgcatca agtaacagca gtgggtctct ctcaccttct     2280

tcttcttctg attgcctggt gaaccgggga ggacctggcc ggagtcatgt ggcagcatta     2340

agaagtcgtt tcgaattgga atatgctcta aatgcaaggt cctatgctgc tttgtcccaa     2400

agtgctggac aatattcctc tcaaggtctg tctttggagg agatgaaaag aagtcttcaa     2460

tacacaccca ttgacaaata tggctatgta tccgatccca tgagctcaat gcattttcat     2520

tcttgccgaa atagtagcag ctttgaggac agcagctgac agcattcggc gtatacctaa     2580

ggagagtttt ttccccgaac tgacagcaac gattccaacc acggcaagct ggcttccaac     2640

tataacattt tactctcaaa ggtctcctta aattgggctt gtttttactt gtcctattta     2700

attccccact attagcaggc tttggatttg tgcctaagga ataatatgca aaagaaccaa     2760

gacagaatgt atatgaagaa ttgtttttaa ttttgtaaat taaaaaaaaa tttagatcgt     2820

tacttggaaa tggagcctaa gtctgtggtg gacagataat aattatgttt tcctgggctg     2880

aattatgtag acttgtgttt gacagctatg ggtttatttc ttagaacatt gttcattttc     2940

ttttctcatt atgttacttc tagtgttcac ctctgtgatt aaagattctt tggtgaaata     3000

g                                                                     3001


<210> 976
<211> 4164
<212> DNA
<213> Homo sapiens

<400> 976
gagcggccgc gccccctgcg ctgccaaccc gcgagcccgc atcatggatg tcgagctccc       60

ctatttcgca ttgctagccc tggaattcga gaccccagac gaggaccagg attcatgaaa      120

tcagtcgcag gggccggggc aggggcctct ggctcccgac actggccgag aggtgatgag      180

tgaggttcga agaacggaag atttaaaaag cagccggggc ctccgtattg aatgaaagac      240

ccagtgcaaa gacatcacca tgaacactag cattccttat cagcagaatc cttacaatcc      300

acggggcagc tccaatgtca tccagtgcta ccgctgtgga gacacctgca aaggggaagt      360

ggtccgcgtg cacaacaacc acttccacat cagatgcttc acctgtcaag tatgtggctg      420

tggcctggcc cagtcaggct tcttcttcaa gaaccaggag tacatctgca cccaggacta      480

ccagcaactc tatggcaccc gctgtgacag ctgccgggac ttcatcacag gcgaagtcat      540

ctcggccctg ggccgcactt accaccccaa gtgcttcgtg tgcagcttgt gcaggaagcc      600

tttccccatt ggagacaagg tgaccttcag cggtaaagaa tgtgtgtgcc aaacgtgctc      660

ccagtccatg gccagcagta agcccatcaa gattcgtgga ccaagccact gtgccgggtg      720

caaggaggag atcaagcacg gccagtcact cctggctctg gacaagcagt ggcacgtcag      780

ctgcttcaag tgccagacct gcagcgtcat cctcaccggg gagtatatca gcaaggatgg      840

tgttccatac tgtgagtccg actaccatgc ccagtttggc attaaatgtg agacttgtga      900

ccgatacatc agtggcagag tcttggaggc aggagggaag cactaccacc caacctgtgc      960

caggtgtgta cgctgccacc agatgttcac cgaaggagag gaaatgtacc tcacaggttc     1020

cgaggtttgg caccccatct gcaaacaggc agcccgggca gagaagaagt taaagcatag     1080

acggacatct gaaacctcca tctcaccccc tggatccagc attgggtcac ccaaccgagt     1140

catctgcgac atctacgaga acctggacct ccggcagaga cgggcctcca gcccggggta     1200

catagactcc cccacctaca gccggcaggg catgtccccc accttctccc gctcacctca     1260

ccactactac cgctctgctg gagacagtaa catctaccgg aaacccccga tctacaaacg     1320

gcatggtgat ttgtctacag caaccaagag caaaacaagt gaagacatca gccagacctc     1380

caagtacagt cccatctact cgccagaccc ctactatgct tcggagtctg agtactggac     1440

ctaccatggg tcccccaaag tgccccgagc cagaaggttc tcgtctggag gagaggagga     1500

tgattttgac cgcagcatgc acaagctcca aagtggaatt ggccggctga ttctgaagga     1560

agaaatgaag gcccggtcga gctcctatgc agatccctgg acccctcccc ggagctccac     1620

cagcagccgg gaagccctgc acacagctgg ctatgagatg tccctcaatg gctcccctcg     1680

gtcgcactac ctggctgaca gtgatcctct catctccaaa tctgcctccc tgcctgccta     1740

ccgaagaaat gggctgcaca ggacacccag cgcagacctc ttccactacg acagcatgaa     1800

cgcagtcaac tggggcatgc gagagtacaa gatctaccct tatgaactgc tgctggtgac     1860

tacaagagga agaaaccgac tgcccaagga tgtagacagg acccgtttag agcgccacct     1920

gtcccaggaa gagttctacc aagtctttgg catgaccatc tctgagtttg accggctggc     1980

cctctggaag aggaatgaac tgaagaagca agcccggctg ttctaggcag aggctctata     2040

aatatatatg catttatata aagatatatg taaaatctct ctactgaagc tcggtataat     2100

cctctcttgt gtaatgggac acactgcctg ccatgagact tgcttttctg tactgtcagg     2160

caagcccacg tcatcgagat atttttatgc tccttacttt ctcttttcta agtgctgtgg     2220

gatctgggaa gggatttgag gggactctgt ccttttattg gggatccttt ttatactgaa     2280

acatctgtcc taacttgagt gccccaaggt ccaactctct ttcctaaaga aggtgcctga     2340

agaagtctct cttctctctg cttcgtggcc cctttcttaa atttctaggg ctgatgctga     2400

ccatgtggtt tccacacctt attggcccca gaggggccct cccatgggaa gatctgcagc     2460

agtctcccca aatcagtgag cacctttgag cgcccacgaa gaactttctc aacaccccca     2520

attaggagct cagtgctctc ttggggcaat gcagttaaaa gggtgagcct caaatctagt     2580

cattacacca gtcaacagaa gtggacaggg cctaggcctc tcctcagctc cttaaccctc     2640

ctccttctgc cctggattgt aacctctccc ttgtccaaat ctaggattcc tggtaggaaa     2700

aggaaaaggc ccttcccttc cctccaccac ttccaactgg cccctttgcc tgacctggac     2760

ttggagaacc agaggaaaag agagggagcg gaagtgggag atggagcagg gcacctgtta     2820

gaatcagagc tgcaggattt cttgggaccc tcctctctcc ctcactgctc ccagcacctc     2880

ctgacccttc cctctttcaa ggagaagccc atgattgcag cttgtattct ttagccttat     2940

tacaatctat gtgcctgaca actcaacaca ccgcagggct aatgttccca ccagagctcc     3000

aactgaacaa ccagacagac aactctcatc atcctccaga gagaaaatag gccgtgtctc     3060

aaagaaaggt tcttggtcta tgcctctggt ctgtgggctg gcagggcaac cataccatac     3120

ccccgccagt cctcggctcc tgctgcaaag ttggccatgt ttcacaggga aacttttgga     3180

agagtggctg cttatgagat tccaaaatga agtgttggcc aacaccgctc atggccatcc     3240

tggattttcc cagtggcttc ccttcctgct cgcctccctg aacaggggag aaagcttaac     3300

ctctcttctc ctctccaaac ctttcacctt gaatgggtaa tgtttggtgg gggctgttcc     3360

ttcttggaga agccttgagt cggaccattt tgagatcatg gaggaaggat gaagaagtga     3420

aaatgacaat aatgactctc aagaggctgg cgatgtgaca tggcaaatgt agaactgact     3480

taaattgaac aaaccctcac tgagcacctc tgatgttgag cacctgctga atactgagca     3540

ctgaatgggg gagggggagg ggagcacggg gtgagtcaac ctgggactcg gtctcaggga     3600

tatgcctacc aatagcgggt atcgtaaggc atgtacccaa acataacgga tgtaaggcag     3660

aaagtgatcg gagaaggaat gagaaagtgt gcgtgatgtt aatgaaaagt catatgcagc     3720

tagagcagac ccaggaaagc tttctggaag agattgcatc tgaggaaatt caggaaggat     3780

ctttgtagat tggggggaga ttctaaattg aaggggtgat ggggtgaggg gccagaggga     3840

agtctgctgt gttctcatgt aggatgtcag ccctccctgc aacttctctt tttggccaat     3900

gtcttttcac tttcctgacc ctttagaatc atccccagcc agacgcaatc atggaagttg     3960

ccttattgtc actggttaag aacttggcga gattgaaggg cttttgttat tgttgttgga     4020

tatttttgtt tcccataaaa gcacatcatt tcaaccctaa acctgtgtgc ttctgttgtt     4080

tcttgtgtgg gagtggaaat gactgacatg ggaagaggct gaaccctgca catttttcaa     4140

aatgaaagca ccaaaacagc agcc                                            4164


<210> 977
<211> 1967
<212> DNA
<213> Homo sapiens

<400> 977
gttgcgcgcc gtggcggcct ctgtgcagtc gccggttccg gaggagggcc caacccggct       60

gggtgggtgg gaagtgtggc tggtaacctg gcagccgcgg agagagagaa gattataaat      120

ggcagagcca tttaactgtg gttagctgtt ggattctgat actttcttaa aaatacgttc      180

ttgcaccaac atcttcattg ggaacagttc agaaaaagca aagaggagag ccaacattca      240

catttaccat ggctatacca ataacagtgc ttgactgtga cctcttgcta tatggccgtg      300

gtcaccggac attggaccgt tttaagctgg atgatgtgac tgatgaatac ttgatgtcca      360

tgtatgggtt tccacggcag ttcatttatt acttggtgga gctcttgggg gcgaatcttt      420

ctaggcctac tcagcgatcc agggctatta gcccagagac acaggtcctt gcagcattgg      480

gtttttatac ctcaggttcc ttccagactc ggatgggaga tgccattgga atcagtcagg      540

cgtctatgag tcgttgtgtt gccaatgtca ctgaagcact tgtggaaagg gcctcacagt      600

tcattcgctt tccagctgat gaagcctcca ttcaggctct gaaggatgaa ttctatgggt      660

tggcagggat gccaggggtg atgggggtgg ttgactgtat ccatgtggcc atcaaggcac      720

caaatgctga agacctctcc tatgtgaacc gaaaaggcct gcattcttta aactgcctga      780

tggtgtgtga cattagaggg acactaatga ccgtggagac aaactggccc ggcagcctac      840

aggactgtgc tgtgctgcag cagtcttccc tcagtagtca gtttgaagcg ggtatgcaca      900

aagatagctg gcttctgggt gacagttcct tctttcttcg aacctggctc atgaccccac      960

ttcacattcc tgaaactcca gcagaatatc gctataacat ggcccattct gcaactcaca     1020

gtgtgattga gaagactttc cgaaccctct gctcccgatt ccgctgcctg gatggatcca     1080

agggggcact gcagtactca ccagagaaat ccagccatat catcttggcc tgttgtgtcc     1140

tccacaacat ctccctggag catgggatgg atgtttggtc ctctccaatg acaggaccca     1200

tggaacagcc cccggaagag gagtatgagc acatggagtc cctggactta gaggctgacc     1260

gtattcgtca ggagctaatg ctcactcatt ttagctaatg tagaaggtgg agaggaggga     1320

tacttcccag gagttgtgac agactttcct cctcatcacc ttttacacag ttccatcatc     1380

tagcatgact gagtatacag atacttgtca taaactgaca tttaatatgt gtgttttggt     1440

aaggttgggg ctatgccaga atatcttgat tcatttgcat atgcattaat taaactgaaa     1500

ccaagacagc ggctccctac tatccagtga actctaggtt gagtaccact aatttgaaag     1560

ctcagtggtt gcaaacattt atgactgtgc ctacaaagtc atagtaaagg tcaggagttc     1620

aagacaagac cagcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaaatt     1680

agcggccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc     1740

ggatcacctg agttcaggag ttaagaccag cctgggcaac atggcaagac cctgtctcta     1800

ctaaaaatac aaaaaaatta gctgggcgtg gtgacaggtg cctgtaatcc cagctactcg     1860

gtaggctgag gcaggagaat cacttgaacc agggaggcgg aggttgtggt gagccgagat     1920

cgtgccattg cactccagcc taggcaagaa gagcgaaact ccgtctc                   1967


<210> 978
<211> 3972
<212> DNA
<213> Homo sapiens

<400> 978
gcggtggtgg tggcggccgc tggccagtgt aagatggcgg cggcgttggt ggtggcagtg       60

gacggggcgg ctgggcctgg aacagtcgga gcagccgcta gcagaaggat gacccaagac      120

gggaagcggg ctgctgagcc tcgccgattc ccgtgcttgt aactgcccca gccggacacc      180

ccccctccct tgacctaccc gtccttcagt gaatctacag acctattttc tcaggagctc      240

agcctggcct tacttcagtg ataaaaggag gaaaggctgg ctacagcaaa catcattcaa      300

gatgtccagc aaagggagca gcacagatgg cagaacagac ttagctaatg gaagcctgtc      360

tagcagtcca gaggagatgt ctggagctga agaggggagg gagacatcct caggcattga      420

agtggaggcc tcagacctga gtttgagctt gactggggat gatggtggcc ccaaccgcac      480

cagcacagaa agtcgaggca cagacacaga gagctcaggt gaagataagg actctgacag      540

catggaggac actggtcatt actccattaa tgatgaaaat cgagtccatg accgctcaga      600

ggaagaggaa gaggaggaag aagaggagga agaagagcag cctcggcgcc gtgtacagcg      660

caagcgggct aaccgtgacc aggactcatc agatgatgag cgggccctag aggactgggt      720

gtcctcagaa acatcagctc taccccgacc tcgctggcaa gccctccctg cccttcggga      780

gcgggagctg ggttcaagtg cccgctttgt ctatgaggcc tgtggggcaa gagtctttgt      840

gcagcgtttc cgcctgcagc atgggcttga gggccatact ggttgtgtca ataccctgca      900

ctttaaccag cgcggcacct ggctggccag tggcagcgat gacctgaagg tggtggtgtg      960

ggattgggta cggcggcagc cagtactgga ctttgagagt ggccacaaaa gtaatgtgtt     1020

ccaggccaag tttcttccta acagtggtga ttctactctg gccatgtgtg cccgtgacgg     1080

gcaggttcga gtagcagaac tgtctgccac acagtgttgc aagaatacaa aacgtgtggc     1140

ccagcacaag ggagcgtccc acaagttggc actggaacca gactctccct gtacgttctt     1200

atctgcaggt gaagatgcag ttgttttcac cattgacctg agacaagacc gcccagcgtc     1260

gaaactggtg gtgacaaaag agaaagagaa gaaagtgggg ctgtatacga tctatgtgaa     1320

tcctgccaat acccaccagt ttgcagtggg tggacgagat cagtttgtaa ggatttatga     1380

ccagaggaaa attgatgaga atgagaacaa tggagtactc aagaagttct gtcctcatca     1440

cctggtgaac agtgagtcca aagcaaacat cacctgtctt gtgtacagcc acgacggcac     1500

agagctcctg gccagttaca atgatgaaga catttacctc ttcaactcct ctcacagtga     1560

tggggcccag tatgttaaga gatacaaggg ccacagaaat aatgccacag taaaaggcgt     1620

caatttctat ggccccaaga gtgagtttgt ggtgagcggt agtgactgtg ggcacatctt     1680

cctctgggag aaatcatcct gccagattat tcagttcatg gagggggaca agggaggcgt     1740

ggtaaactgt cttgagcccc accctcacct gcctgtgctg gcaaccagtg gcctagacca     1800

tgatgtgaag atctgggcac ccacagctga agcttccact gagctgacag ggttaaaaga     1860

tgtgattaag aagaacaagc gggagcggga tgaagatagc ttgcaccaaa ctgacctgtt     1920

tgatagtcac atgctgtggt tccttatgca tcacctgaga cagagacgcc atcaccggcg     1980

ctggcgagaa cctggggttg gggccacaga cgcggactct gatgagtctc ccagctcctc     2040

agacacatcg gacgaggagg agggccctga ccgggtgcag tgcatgccat cttgaggcct     2100

catacctagg tggggcaggc tggggctgcc aacctgatcc tgcctgggca accctttcct     2160

gtcccaggcc ctacattcag cagaaacgca ctttggactt tttgctttag ataaaagaaa     2220

gacatcccag gagaaggaca aaccagagga gtgaaccaac aaagagtacc taggaatggg     2280

agttgagccc tggaatgggg ctctatggag aggtgcatag gactcggcag aaatggcctc     2340

tccccaaagc ctctttttga gaggagaggg aagcctattt tgttaactgg tttgggatag     2400

ggaatggggt ttctttttct ttaatctccc ttgtttcttg ggctggggga ggggtggggg     2460

gaacaactgg ctattcagta ccaaggggcc agagtggagg gtaggagtgc cactctctct     2520

ttggtttagg tttttgacct tttcttcctt tgttttttaa aagtttatga cagttggctc     2580

cccccccacc cccagcaacc ccatcccaga atcctatttt cctgggaagt ccttaaagcc     2640

cctaaccatc ccacactctt cactttcctt tccaccttat tcattctctg tacttaccac     2700

agtattttgc acttgattac atatccttca ctctcttctc ttcatcccat caccccctaa     2760

ataggtcagg tgagggaggc tgggaagagg tgggaggagg ggcagaagtg aaggaagaat     2820

aggaaggata ttacctcttc tgttattttt ttaagaaaca ttgtttggtg gcagcaatct     2880

ccctgtccct atcactgtta gaggcctaat tttatatcta taaatatatt aaaaagcaag     2940

tcaaacttgg atgtatcaag gtaaaattat tgtcaaagtt taaataccta tatattctct     3000

gaatgcaata aagggactta agagtgaaca agagtaatgg tgtggaagtg acacctgggg     3060

tcagtttacc tctgtgtatg gtcactagag attgggactt accctttagg ttttaggagg     3120

cttgagaatg gaaggatcct catttctgcc cttcctggtt ccctgctttg gtgtaggggt     3180

tgggaaaaac aggaaattcc tctcagctct gcctcagatc tcctacctct ccttaagtct     3240

tgtagggggt tccaaggatg gctcttctaa ccagaggctg gcctgtcttt aaaacttaac     3300

tactttaggg tggtgccacc actgcagact attgtggtac tttgtgacag aagacatgta     3360

cacacacacc acacacatac atacacactc tctcactctg tctctcttac ctttagctgc     3420

ttgatcatta agccatccaa cttcatgcca gttcccttct ttatagaaga gtgaagggaa     3480

agacttcctg ggtttgactt aaaccttgtc cacctcttga tattttagga ttgaggaata     3540

agtcattaat ctaaggactg attacagtgg ctggagcttg ggcacttgtc ttatcactgg     3600

tcactgagtc tgaaagtccc agctgaattc ttgcccttaa gtgcttttgc tgctattttt     3660

ttgcccccag ttccacaaga tccaaccaag aattctgtat cctgggacag tcagattctt     3720

ctaaatcagg ccaggaagga ggggaaaaga gtgagagaat ggtattccca gatacttctt     3780

cctcctgccc cttttcccag cagctctgag accagatgtt ggctgctgta cttactccct     3840

gaggtaggga atgtgtggtg atcgagtggt ctgtgttcct attgctggtg gggtgatagg     3900

gtgggctaaa aaccatgcac tctggaattt gttgtatttt ctcccagtaa agcttttctt     3960

ctcccgactg ct                                                         3972


<210> 979
<211> 2651
<212> DNA
<213> Homo sapiens

<400> 979
agtttctcct ttgttttacg tttgggagga ggtggcattg gaaatagcag agtgcttcgc       60

ggtaacaggg gttggagtgc aatggtgtga tctcagctca ctgcaacccc tgcctcccag      120

gctccagcga tcctcccacc tcagcctcct gaatagctga ccaccagcac actaggcaaa      180

cccaccccac tcacggcctc ccttgggaat tcagacctaa ccatcgctga gctgaaacaa      240

atgtactgag gctggagcct gtgtgaacag aacagaagag gccttcactc tagtagtgct      300

cacagtccag caggtgtttg ctgaagacag cttactcaga tcactactgc ctggaggtgg      360

ttgatatatc ctggtgtaaa ccttcaagaa gggcacaggc aggaaaacat gagccagcaa      420

ctgaagaaac gggcaaagac aagacaccag aaaggcctgg gtggaagagc ccccagtggg      480

gctaagccca ggcaaggcaa gtcaagccaa gacctgcagg cggaaataga acctgtcagc      540

gcggtgtggg ccttatgtga tggctatgtg tgctatgagc ctggccctca ggctctcgga      600

ggggatgatt tctcagactg ttacatagaa tgcgtcataa ggggtgagtt ttctcaaccc      660

atcctggaag aggactcact ttttgagtcc ttggaatacc taaagaaagg atcagaacaa      720

cagctttctc aaaaggtttt cgaagcaagc tcccttgaat gttctttgga atacatgaaa      780

aaaggggtaa agaaagagct tccacaaaag atagttggag agaattcgct tgagtattct      840

gagtacatga caggcaagaa gcttccgcct ggaggaatac ctggcattga cctatcagat      900

cctaaacagc tcgcagaatt tgctagaaag aagcccccca taaataaaga atatgacagt      960

ctgagcgcaa tcgcttgtcc tcagagtgga tgcactagga agttgaggaa tagagctgcc     1020

ctgagaaagc atctcctcat tcatggtccc cgagaccacg tctgtgcgga atgtgggaaa     1080

gcgttcgttg agagctcaaa actaaagaga catttcctgg ttcatactgg agagaagccg     1140

tttcggtgca cttttgaagg gtgcggaaag cgcttctctc tggactttaa tttgcgtacg     1200

cacgtgcgca tccacacggg ggagaaacgt ttcgtgtgtc cctttcaagg ctgcaacagg     1260

aggtttattc agtcaaataa cctgaaagcc cacatcctaa cgcatgcaaa tacgaacaag     1320

aatgaacaag agggaaagta gtcctccaac aggatgaagc agattaacag aagagtgatc     1380

agtgacaaac atgcctcatt gattattgtt tctaggaagg aatttctaaa tcaatattgc     1440

aaccccaaaa gcggttataa tttggtgtta ctaagatgct cctacacttt gtgataccgt     1500

tttaaggaca tggtgcattt ttttttcttt tatttgtttt atttagaact ttttttattt     1560

gttttattta gaactttgtg tgttcttaaa gtgtgcttcc aacaggaagg tcagtgataa     1620

attttcaaaa gcataacctt caatatatta tctgttggat tattggatat aagacttatt     1680

ttcatgtact ataaatatga aaataacttt gatttttaat tgtgtagttt ccatttctta     1740

gcttttgcct tttaaattta tacttcagcc aggcatagtg actgatgcct gtaatcccaa     1800

cactttgttg ggaggccaaa gcaggaggat agcttgaggc caggagttcc agaccagcct     1860

gggcaacata gtgagatcct gtctctacaa aaaaatttgt ttttatttgt atttatatat     1920

ttttattttt gtttttgttg gtaggcgtct cgctctgtca cccaggctgg agtctagtgt     1980

cgtgatcttg gctcactgca acctccacct cccgggttca agtgattctc tggcctcagc     2040

ctcccaagta gctgggacta caggtgtgtg tcaccacgcc cggctaattt ttgtattttt     2100

agtagagatg gggtttcacc atgttggcca ggctagtctc aaactcctga cctccagtga     2160

tctgcccacc tcggcctccc aaagtgctgg gattacaggt gtgagccact gtgcctggcc     2220

ccccacaaca tgtttaaact tagctaggcc tggttgcata cgcctgtgtt cccagctact     2280

caggaggctg aagcaggagg atagcttgag cccaggagtt tgaggctaca gtgagctgtg     2340

attgcaccac tgtactccag actggataac agcaagagcc catcttttaa aaaaagtaaa     2400

aattaaaaat atacttcatg gttcatgtca tagccctaga gaatgaaaaa tttgcagtag     2460

atagtcaata aatgaatcag tagttaaata ttccttaaag tcaactgtat ttcattgtga     2520

tttttgtttt ctttttatca ttgtatcaaa ctatatggaa atcatatggt tagatgtgat     2580

tatttgataa tgttagtcca tttgaatcca ttttagatat ttcacaatta aagaatatga     2640

aacttcagaa a                                                          2651


<210> 980
<211> 1909
<212> DNA
<213> Homo sapiens

<400> 980
gcacagctgc ccgccggaag aaccgagctt ggctgtgttt atctcgttgg ggactaaggc       60

gtcggttggc gcgcaacggg ttctaggctg caggcagctc gaggacccgc ggccccgccc      120

cggctcggcc tggcagatag cagaggcagc aggccgtgcc gggggggcat gttgctgtaa      180

ccagtggccc aggggatgtt acggtggaca gtgcacctgg agggcgggcc ccgcagggtg      240

aaccatgctg cagtggctgt cgggcatcgg gtatactcct tcgggggtta ctgctctggt      300

gaagactatg agacactgcg tcagatagat gtgcacattt tcaatgcagt gtccttgcgt      360

tggacaaagc tgcccccggt gaagtctgcc atccgtgggc aagctcctgt ggtaccctac      420

atgcgctatg gacactcaac cgtcctcatc gacgacacag tcctcctttg gggcgggcgg      480

aatgacaccg aaggggcctg caatgtgctc tatgcctttg acgtcaatac gcacaagtgg      540

ttcacacccc gagtgtcagg gacagttcct ggggcccggg atggacattc agcctgtgtc      600

ctaggcaaga tcatgtacat ttttgggggc tacgagcagc aggcggactg tttttccaat      660

gacattcaca agctagatac cagcaccatg acatggactc ttatctgtac aaagggcagc      720

cctgcacgct ggagggactt ccactcagcc acaatgctgg gaagtcacat gtatgtcttt      780

gggggccgtg ccgaccgctt tgggccattc cattccaaca atgagattta ctgcaaccgc      840

attcgagtct ttgacaccag aactgaggct tggctggact gtcccccgac tccagtgctg      900

cctgaggggc gccggagcca ctcggccttt ggctacaatg gggagctgta catctttggt      960

ggttataatg caaggctgaa ccggcacttc catgacctct ggaagtttaa tcctgtgtcc     1020

tttacctgga aaaagattga accgaagggg aaggggccat gtccccgccg gcgccagtgc     1080

tgctgtattg ttggtgacaa gattgtcctc tttgggggta ccagtccatc tcctgaggaa     1140

ggcctgggag atgaatttga ccttatagat cattctgact tacacatttt ggactttagc     1200

cctagtctga agactctgtg caaactggcc gtgattcagt ataacctaga ccagtcctgt     1260

ttgcctcatg atatcaggtg ggagctgaat gccatgacca ccaacagcaa tatcagtcgc     1320

cccatcgtct cctcccatgg gtaggaggaa gtttctgcca cctcccctcc tgagcctgct     1380

gtcatcttca ctgcccctgc ccatctgtca cccacctgct cctttgaccc ctggacttgg     1440

tatacctcca tgtggagttg ttgggcgaga ggtgttctct gtgctgtgaa ttcagtgggg     1500

agctgtagcg gggtgggggc taggttcctc cccccttggg ccgagggccc cttccccttg     1560

gtgctctgtc cccatccacc tcctttcagc tgctcctggg cctcagctct gcccagggcc     1620

agccaggttc tgctgggaag ggaagggaat ggggagaagg gagaagcaag cagtgtctga     1680

gcctcaggag cttccccctc cccctttgcc tatcccctcc cctctgcttg agccttgagc     1740

cttgactggg agctgaaagg agttgcagct gttggcatga gacctccttc tccccgtctt     1800

ggggaggtgg ggaccagcag ataaatccca cccttccttg agctgtcgct gtactctgaa     1860

gttcagccag ctcagatttt ataaaaatta attaaaatct ccaaacgtg                 1909


<210> 981
<211> 2968
<212> DNA
<213> Homo sapiens

<400> 981
ggcggtagcg gcagcggcgg cggcggcggc ggcggcggcg gcggcggcgg cggcggcggc       60

ggcagcggcg gcggcctggg cccgggcgca gcggcggcgg cggcggggcc tggagccgga      120

tctaagatgg cagcggcggc ggcggcggtg gggccgggcg cgggcggcgc ggggtcggcg      180

gtcccgggcg gcgcggggcc ctgcgctacc gtgtcggtgt tccccggcgc ccgcctcctc      240

accatcggcg acgcgaacgg cgagatccag cggcacgcgg agcagcaggc gctgcgcctc      300

gaggtgcgcg ccggcccgga ctcggcgggc atcgccctct acagccatga agatgtgtgt      360

gtctttaagt gctcagtgtc ccgagagaca gagtgcagcc gtgtgggcaa gcagtccttc      420

atcatcaccc tgggctgcaa cagcgtcctc atccagttcg ccacacccaa cgatttctgt      480

tccttctaca acatcctgaa aacctgccgg ggccacaccc tggagcggtc tgtgttcagc      540

gagcggacgg aggagtcttc tgccgtgcag tacttccagt tttatggcta cctgtcccag      600

cagcagaaca tgatgcagga ctacgtgcgg acaggcacct accagcgcgc catcctgcaa      660

aaccacaccg acttcaagga caagatcgtt cttgatgttg gctgtggctc tgggatcctg      720

tcgttttttg ccgcccaagc tggagcacgg aaaatctacg cggtggaggc cagcaccatg      780

gcccagcacg ctgaggtctt ggtgaagagt aacaacctga cggaccgcat cgtggtcatc      840

ccgggcaagg tggaggaggt gtcactcccc gagcaggtgg acatcatcat ctcggagccc      900

atgggctaca tgctcttcaa cgagcgcatg ctggagagct acctccacgc caagaagtac      960

ctgaagccca gcggaaacat gtttcctacc attggtgacg tccaccttgc acccttcacg     1020

gatgaacagc tctacatgga gcagttcacc aaggccaact tctggtacca gccatctttc     1080

catggagtgg acctgtcggc cctccgaggt gccgcggtgg atgagtattt ccggcagcct     1140

gtggtggaca catttgacat ccggatcctg atggccaagt ctgtcaagta cacggtgaac     1200

ttcttagaag ccaaagaagg agatttgcac aggatagaaa tcccattcaa attccacatg     1260

ctgcattcag ggctggtcca cggcctggct ttctggtttg acgttgcttt catcggctcc     1320

ataatgaccg tgtggctgtc cacagccccg acagagcccc tgacccactg gtaccaggtg     1380

cggtgcctgt tccagtcacc actgttcgcc aaggcagggg acacgctctc agggacatgt     1440

ctgcttattg ccaacaaaag acagagctac gacatcagta ttgtggccca ggtggaccag     1500

accggctcca agtccagtaa cctcctggat ctgaaaaacc ccttctttag atacacgggc     1560

acaacgccct cacccccacc cggctcccac tacacatctc cctcggaaaa catgtggaac     1620

acgggcagca cctacaacct cagcagcggg atggccgtgg cagggatgcc gaccgcctat     1680

gacttgagca gtgttattgc cagtggctcc agcgtgggcc acaacaacct gattccttta     1740

gccaacacgg ggattgtcaa tcacacccac tcccggatgg gctccataat gagcacgggg     1800

attgtccaag ggtcctccgg cgcccagggc agtggtggtg gcagcacgag tgcccactat     1860

gcagtcaaca gccagttcac catgggcggc cccgccatct ccatggcgtc gcccatgtcc     1920

atcccgacca acaccatgca ctacgggagc taggggcccg ccccgcggac tgacagcacc     1980

aggaaaccaa atgatgtccc tgcccgccgc ccccgccggg cggctttccc ccttgtactg     2040

gagaagctcg aacacccggt cacagctctc tttgctatgg gaactgggac acttttttac     2100

acgatgttgc cgccgtcccc accctaaccc ccacctcccg gccctgagcg tgtgtcgctg     2160

ccatatttta cacaaaatca tgttgtggga gccctcgtcc cccctcctgc ccgctctacc     2220

ctgacctggg cttgtcatct gctggaacag gcgccatggg gcctgccagc cctgcctgcc     2280

aggtccctta gcacctgtcc ccctgcctgt ctccagtggg aaggtagcct ggccaggcgg     2340

ggcctcccct tcgacgacca ggcctcggtc acaacggacg tgacatgctg ctttttttaa     2400

ttttattttt ttatgaaaag aaccagtgtc aatccgcaga ccctctgtga agccaggccg     2460

gccgggccga gccagcagcc cctctcccta gactcagagg cgccgcgggg aggggtggcc     2520

ccgccgaggc ttcaggggcc ccctccccac caaagggttc acctcacact tgaatgtaca     2580

acccacccca ctgtcgggaa ggcctccgtc ctcggcccct gcctcttgct gctgtcctgt     2640

ccccgagccc ctgcaggtcc ccccccgccc ccccactcaa gagttagagc aggtggctgc     2700

aggccttggg cccggaggga aggccactgc cggccacttg gggcagacac agacacctca     2760

aggatctgtc acggaaggcg tcctttttcc ttgtagctaa cgttaggcct gagtagctcc     2820

cctccatcct tgtagacgct ccagtcccta ctactgtgac ggcatttcca tccctcccct     2880

gcccgggaag ggaccttgca gggacctctc cctccaaaaa aagaaaaaaa gaaaaagaaa     2940

gaaaaaataa atgaggaaac gtgttgca                                        2968


<210> 982
<211> 2985
<212> DNA
<213> Homo sapiens

<400> 982
ggaaggcgct gggacggtta cccagcgggc cgccggcggt cgtgggcaag cttcgccatg       60

cagagcactg acctaggcaa caaggagagc ggcaagatat ggcaccgcaa gccgtccccg      120

gccacgcggg acggaattat agtgaacatt attcacaaca cttccgatta ccatccaaaa      180

gttttgcgat ttttgaatgt ggcttttgat ggcacaggcg actgcttaat tgctggggac      240

caccaaggaa atatttatgt ttttgactta catggaaaca ggttcaatct tgttcagcga      300

acagcacaag cttgcacagc tctggccttt aatcttcgta ggaaatctga attccttgtg      360

gcattagctg attattctat taaatgtttt gatacagtca ccaaggagct agttagctgg      420

atgagaggac atgaatcatc agtattttcg atctctgtgc atgcatcagg gaaatatgcc      480

atcacaactt cttctgatac agcacaatta tgggacttgg atacctttca gagaaaaaga      540

aagctgaata ttcgccagtc tgtgggtata cagaaggttt tctttctacc attaagtaat      600

accatcctca gctgttttaa agataattcc atttttgcct gggaatgtga cacacttttt      660

tgcaaatatc aattgccagc tccacctgaa agctctagta tattatacaa agtgtttgct      720

gtaaccagag atggccgaat cctggctgct ggaggcaagt caaatcatct tcatttgtgg      780

tgcttggaag ctaggcagct ctttagaatt atccagatgc ccactaaagt tcgagccatt      840

cgccatctgg aatttcttcc tgatagtttt gatgctggtt ctaatcaggt tcttggagta      900

ctaagtcaag atggtattat gagatttatc aatatgcaga cttgtaaact tctctttgag      960

attgggagcc tcgatgaagg aattagctca tcagcaatta gcccacatgg acggtacatt     1020

gcatctatta tggaaaatgg aagtctaaac atatattcag ttcaggcttt aacacaagaa     1080

ataaataagc cacctccgcc tttagtgaaa gttattgaag atttgcccaa gaataaactg     1140

agttccagtg atcttaagat gaaagtaaca tcagggagag tacagcagcc agcaaaatct     1200

agggaaagca aaatgcaaac tagaatatta aaacaagacc tgactggtga ttttgaaagt     1260

aaaaagaatg aattaccaga tggattaaac aaaaagcgtt tacaaatctt attaaaaggc     1320

tatggtgaat atccaacaaa atacagaatg ttcatttggc gctctctgct acaactgcct     1380

gaaaatcata ctgcgtttag taccctcata gataagggga ctcatgtggc atttctcaac     1440

cttcagaaga aataccccat caaaagtagg aagctactca gagtattaca gagaacctta     1500

tctgcattag ctcactggtc tgtcattttt agtgacacac catatcttcc actcttggca     1560

tttccatttg taaaattatt ccagaacaac caactcatct gttttgaagt tattgctact     1620

ctcataatca attggtgtca acactggttt gaatattttc ctaatcctcc tatcaatatt     1680

cttagcatga tagaaaatgt tttggcattt catgacaagg aactgctgca acacttcata     1740

gatcatgata taacctccca gctatatgca tggcctcttc ttgaaactgt gttctcagaa     1800

gtgctgacaa gagaggagtg gctgaaattg ttcgataata tcttttccaa ccatccttcc     1860

ttccttctga tgactgttgt agcctacaac atatgttcta gaacgcctct gctcagctgt     1920

aatcttaaag atgactttga gttttttttt caccatcgga ataacctgga tataaatgtt     1980

gtgattagac aagtttatca tctcatggag accacgccta ctgacattca tccagacagc     2040

atgcttaatg tttttgttgc actgacaaaa gggcagtatc cagtatttaa tcaatatcca     2100

aagtttattg tggactatca aacacaggaa cgagaaagaa taaggaatga tgaattggat     2160

tacttaagag agaggcagac agttgaagat atgcaagcta aagtcgacca gcaaagagtt     2220

gaagatgaag cttggtacca gaaacaggag ctgcttcgta aagctgaaga aacaagaaga     2280

gaaatgctct tacaagagga ggagaaaatg atacaacaaa gacagaggct agctgctgtg     2340

aaaagagagc tgaaagtaaa ggaaatgcac ttacaagatg ctgcaagaag gcgttttctg     2400

aagcttcagc aagatcaaca ggaaatggaa ctaagaagac tggatgatga aattgggaga     2460

aagaatctta ctgaaaatca agaagctctt gcaaaagaaa tgcgagcaga tgcagatgcc     2520

tatagacgaa aagtggatct tgaagaacac atgtttcata agctgataga agcaggtgaa     2580

acccagagcc agaaaactca gaagtggaag gaagctgaag gaaaagagtt ccgtttgaga     2640

tcagcaaaga aagcttctgc tctttcagat gcgtctagaa agtggttttt aaagcaagag     2700

ataaatgcgg ctgtagaaca tgctgaaaat ccatgtcata aagaagaacc caggttccaa     2760

aatgaacagg actcaagctg tttgcctaga acctcacaat taaatgactc ttctgaaatg     2820

gatccctcaa cacagatttc tttaaataga agagcagtag aatgggacac cacgggacag     2880

aatcttatta agaaagtgag aaatcttcgc cagagactca ctgcccgggc tcgtcacaga     2940

tgtcaaaccc ctcatctttt ggctgcatag aatgcatgtc acctt                     2985


<210> 983
<211> 2790
<212> DNA
<213> Homo sapiens

<400> 983
cggcggaggt gtctaccccg ccggtgatgg cgttgaacgc cactggcttc ccggccttcc       60

gtccgctgcc tccgtccgat tctgcgtctg cttgctgagg aggcggatta ggggggcgcg      120

gagtctcttc ccttgagtgc ataggtcccg gttggtagag ggtttgagtc cgcatcgcca      180

cagctgaagg ctgcgaggga ctaagagcag aatatatctt tagaaatgag ttgcacaatt      240

gagaaggcac ttgccgacgc taaagctctt gttgaaagat taagagatca tgacgatgca      300

gcagaatctc tgattgagca aaccacagct ctcaacaagc gagtagaagc catgaaacag      360

tatcaggaag aaattcaaga acttaatgaa gtcgcgagac atcggccacg gtccacgtta      420

gttatgggaa tccagcaaga aaacagacaa atcagagagt tgcaacaaga aaacaaagaa      480

ttacgtacat ctctggaaga acatcagtcg gccttggaac ttataatgag caagtaccga      540

gaacaaatgt ttagattgct aatggctagc aaaaaagatg atccgggtat aataatgaag      600

ttaaaagagc agcactccaa ggaactgcaa gcacatgttg accagataac tgaaatggca      660

gcagtaatga ggaaagccat tgaaattgac gagcaacagg gttgcaagga acaagaacga      720

atatttcaac ttgaacaaga aaacaaaggc ttgagagaga tccttcaaat aactcgagaa      780

tcatttttga acctaaggaa agatgatgcg tcggaaagta cttctttgtc agcattagtg      840

accaacagtg atttgagtct gaggaagagc tgaagagttt ctgagtctgt gagcttctta      900

catggctcca aatggtcaaa taagtgaatg aatgaatgga cagaaaattc aatcctttat      960

ttttttctct gtaaatatgt acagtgcacg ggctatgaga tagcaacaaa aaatgcatag     1020

ttaatggtca tagactttat tccaaaacat aattggaaaa tagaaactga gccattgcca     1080

aatggtaaag aaatgaaaag ttttcacagt gactactgaa tataccaaga gcttttggca     1140

gtactgctgg ctttctgggt gattaattag gtaaacttga atattcccag taaatgtttg     1200

agaatgcata aaattatacc aatttaaaaa tataaatttt tgccactgtt ttgtgaacgg     1260

aggatttgta cgctaaattt catccttatt tggcgtcaaa gttgatgcaa agtttatgta     1320

ccatgagact tctagtgatt gcctactttc acatttattt aaatttttgt gaaagaaaat     1380

acagttttaa aggctatagg aatgtgttat atgtacctta aacagataat ttaattttag     1440

caatttatca taactgatac ttagctaaca attgtccata acttgtttaa gtgtaagaaa     1500

taccatttca ggaatgaaaa agaaggaata ctactttcta agaaagaaga tcttataata     1560

gacatattta gtaggttaaa ctactccttt gaaagaataa gttttggttc aaagtcaata     1620

atgaagacga gatttgtttt tctcttctct ggctgatttt taaggatatt atgtagttca     1680

tttagttaac agaattgaaa tgtttgatat ggcaagatag gtatggtaat ttcaaagtga     1740

attgggaatt cctctggctc atagaaccct tttttttttc ctttaagtat tcttgagata     1800

caaaaaaaaa aagtaaatac aatttcaaaa aaaaagttcc ggatctgttt ttaagctcca     1860

tctggtcctc ataacctgca agatttttct taaaaccttt cagctgaaag tgggggtaaa     1920

ggtggagtaa tctgtggatt tgtttctgtt gtcttttaaa atgtcaaata tataatatgt     1980

aattttttta aaaaccacca gatacagaaa tgtgctttaa catcagttga aacctaaatt     2040

ttcttatgtt gtggtgattg tattaaaaag ggataaaaga agagtgtcaa acatggttaa     2100

atatattgta ctcatttatg ttgaatacgt attaaaatta agacaaatgg aaaattatac     2160

tttgagtata taatttgtta aatattactt tatatggtaa ttttatgtat aatttcatat     2220

attggtaaaa ttcaaaacta cacttgagaa tttttttatc ttaagtttgg ggtgaatggg     2280

gtggatgaga ctgattgaat agaaaagggc taatggccca aacattatat agatttcttt     2340

ttttcagtca gaggccttat ttgatatttt ataaataaat gacagttttt atttttaaac     2400

tttttattgt ttttgggaaa gtattcctta atttaatgac acattcattc agatacttct     2460

tatccctgct aataaaggaa atctatttca agctacacca ttgagattaa gtctgaggca     2520

gttcattgag gcagctctac tataaaagct tacttgataa ataattattt ttgtaaacaa     2580

gttgggttaa cttattcttc gtctttttgc ttggatatga atttaaggtc ttcatgttta     2640

aagacattta ctttgttatt tagtgacaca tttccatcct attttttttt tttttttggt     2700

tgttgttaaa cagaacctta agtttatgtt tgaggtatgt actgcatagg aacctatttt     2760

attattaaag atgaatgatt aaaattggta                                      2790


<210> 984
<211> 7720
<212> DNA
<213> Homo sapiens

<400> 984
gacggttgcc tggtattatt agcaagcagc aaatatggcg gtggcgcgcg tggacgcggc       60

tttgcctccc ggagaaggat cagtggtcaa ttggtcagga cagggactac agaaattagg      120

tccaaattta ccctgtgaag ctgatattca cactttgatt ctggataaaa atcagattat      180

taaattggaa aatctggaga aatgcaaacg attaatacag ttatcagtag ctaataatcg      240

gctggttcgg atgatgggtg tggccaagct gacgttgctt cgtgtattaa atttgcctca      300

taatagcatt ggctgtgtgg aagggctaaa ggaactagta catctggaat ggctgaattt      360

ggcaggaaat aatcttaagg ccatggaaca gatcaatagc tgcacagctc tacagcatct      420

cgatttatca gacaataata tatcccagat aggtgatcta tctaaattgg tatccctgaa      480

aaccctgctt ttacatggaa acatcatcac ctctcttaga atggcacctg cttacctacc      540

cagaagtctt gctatacttt ctttggcaga aaatgaaatc cgagacttaa atgagatctc      600

ttttttggca tccttaactg aattggaaca gttgtcgatt atgaacaatc cttgtgtgat      660

ggcaacacca tccatcccag gatttgacta tcggccgtac atcgtcagct ggtgcctaaa      720

cctcagagtc ctagatggat atgtgatttc tcagaaggaa agtttgaaag ctgaatggct      780

ctatagtcaa ggcaagggga gagcatatcg gcctggccag cacatccagc ttgtccaata      840

tctggctaca gtctgccccc tcacttctac actaggtctt caaactgcag aggatgccaa      900

actagagaag attttgagca aacagaggtt tcaccagagg cagttgatga accaaagcca      960

aaatgaagag ttgtctcctc ttgttcctgt tgaaacaagg gcatccctta ttcctgagca     1020

ttcaagccct gttcaagatt gccagatatc ccaggaaagt gaacccgtca ttcaagtgaa     1080

ttcttgggtt gggataaaca gtaatgatga tcagttattt gcggttaaga ataattttcc     1140

agcctctgta cacactacga gatattctcg aaatgatctg cacctggaag acatacagac     1200

ggatgaggac aagttaaact gtagtcttct ctcttcagag tctactttta tgccagttgc     1260

atcaggactg tctccactat cacctacagt tgagctgagg ctgcagggca ttaacttggg     1320

cctagaagat gatggtgttg cagatgaatc tgtgaaaggg ctggaaagcc aggtgttgga     1380

taaggaagag gaacagcctt tatgggctgc aaatgagaat tctgttcaaa tgatgagaag     1440

tgaaatcaat acagaggtaa atgagaaagc tggactatta ccttgtcctg agccaacaat     1500

aatcagtgct atcttgaagg atgataacca cagtcttaca ttttttcctg agtcaactga     1560

gcagaaacaa tcagacataa agaaaccaga aaatacacaa ccagaaaata aagaaaccat     1620

atctcaagca acttcagaga aacttcccat gattttaacc cagagatctg ttgctttggg     1680

acaagacaaa gttgcccttc agaaattaaa tgatgcagcc accaagcttc aggcctgttg     1740

gcggggattt tatgccagga actacaaccc tcaagccaaa gatgtgcgtt acgaaatccg     1800

gctacgcaga atgcaagagc acattgtctg cttaactgat gaaataagga gattacgaaa     1860

agaaagagat gaagaacgta ttaaaaaatt tgtacaagaa gaagctttca gattcctttg     1920

gaaccagaaa tggggtcttg ccatattgcc caggccggtc tcaaacttct gggctcaagc     1980

agtcttccct cctcagcctc ccaaagtaag gtctctacag gtttggcaac agacagtgga     2040

ccagcgtcta agttcctggc atactgatgt tcctcctata tcaagtactc ttgtgccatc     2100

gaaacatcca ttatttaccc aaagccagga gtcctcttgt gatcaaaatg ctgattggtt     2160

tattgcttct gatgtagctc ctcaagagaa atcattacca gaatttccag actctggttt     2220

tcattcctct ctaacagaac aagttcattc attgcagcat tctttggatt ttgagaaaag     2280

ttccacagaa ggcagtgaaa gctccataat ggggaattcc attgacacag tcagatatgg     2340

caaagaatca gatttagggg atgttagtga agaacatggt gaatggaata aggaaagctc     2400

aaataacgag caggacaata gtctgcttga acagtattta acttcagttc aacagctgga     2460

agatgctgat gagaggacca attttgatac agagacaaga gatagcaaac ttcacattgc     2520

ttgtttccca gtacagttag atacattgtc tgacggtgct tctgtagatg agagtcatgg     2580

catatctcct cctttgcaag gtgaaattag ccagacacaa gagaattcta aattaaatgc     2640

agaagttcag gggcagcagc cagaatgtga ttctacattt cagctattgc atgttggtgt     2700

tactgtgtag catgtctttt gggaggcaga tatccactta acttttctta aaaatacttt     2760

cagttgcctt tgcttttttt tggagggaaa tactccctac ccctaatttt gttactactt     2820

atatagaatt tgtattcatg tcttatattt ttcagattct agatattgag ctgagttttc     2880

attttgattt tgttagcttt ttacttagct gtaaggtacc aaactattta tattgaaagc     2940

tatatgcact ttatttctta actgaattgc atcaacaatg ttcctgtttc tttcatgtac     3000

tcatttactt tcaaaaataa gctagaatat attaaagaaa atagaaaaaa ttaccttaaa     3060

tatataaata agagaatttt ggcccttctg tgtctgagaa aattaattat atagcaagga     3120

atgaaatttg ataaagcaaa tataaatgag aaatatgagg attgtgaatt attgaaattt     3180

gccagtctcc ctggtgtaaa atgttttttt aaagcctttt ttcctccttt cggagtcaag     3240

gaaagccttt ctataagcaa attaaggaag aaaaggtagg attataagat ttctcaatgg     3300

ggatgattaa attgtctcat ggaaaacttc agttaatgtc atgcatcagt tttaacatat     3360

gaagtaaagt gttctatcca ggattaaagt caagtttact taggcaacac aagaatattt     3420

cacttagata tgaagaaagg aaacactagt ctccattcac ttgaaatact ctcatggcaa     3480

atatttatcc tctcattaag tgctttttca ccctataggt aagcattttt gtgccaacat     3540

gttgtcagaa attaatgtat gttcatctcc tctgttcctg cttattttta cttatatatt     3600

tcagcagaag gtccgtggcc attcacttca attttgacct ctgtcccata gtgaagaaca     3660

tttaaagtaa tactactggt cgaatatgaa tgacttttta ggaactactt tttgtctaac     3720

ctgaaaaagt tccacatttg gaagacaatt taatgatggt gaagaaataa taaacctcac     3780

tttacttgtt aaaagggata tatatatata tatatatgtc tgcaacttca gggagaaata     3840

agattgtgtt tgaatattgt aggtagatgc atttgtaatt aaggataata tcgtttaaca     3900

acatgtattt ggtttccctc aacttacaga catacagcta tttaaaacta tggcaatact     3960

taagcatctc taaatttagg tgctaaatat ctattattct gttgtagtca ttaggtgccc     4020

ttctctgaag ttatgtaaaa taaaagcatc tgatccttca aggataaagt tgaggatcac     4080

atggtacgtg gcatttgttg ttattgtttt ttaaagagat ggaggctggc tctgttggtg     4140

cggtgccatg atcatagttc actataacct cgaactcctg gctcaagtga tctcccactt     4200

cagcctcccg agtatctggg attataagca agagccactg ctcccagctc atggtatttg     4260

ttgatagtca taacattttt cctgtatggt aagacgtatt tttctcagtt tataaatacg     4320

tagcactcag gttgagacga cttggatttt attcttagaa atccagaatc ccttgaaaag     4380

gaaatatttt ctgtttctta taaataaaag agtaatctta ctttcagaag gattttcctt     4440

agtgaaacat gtgtaacatt gaatgcatgt taaataaaaa tggaatttct aacttttttt     4500

caatagtgct aattatcttt tctgaatgat tttgaatgtc ttcttaaata taccctattt     4560

ttctatttta aagttaagtg cctcacttgc tgtccatagt tagacaaaga aaaaccaatt     4620

tccactgcac tagtaccaaa atactacttt atacattagt ttttcataaa agctgctgga     4680

atgtcatgat tcagtattac ctaaatagat ttctgctaaa atcctctccc tcctgtcttt     4740

tttaagttat ggaaaaacac aactaaattc atttgatcat cagcacttgt tagcaggatt     4800

tcctttttta cctttgcctt gtttctttag cccacaaata gtactcagca tactttcatt     4860

aaaaatttgg cacaatatga taattgttaa tattctgttc ttcgtctgtg ttttatttaa     4920

cttttactag tgtttagaag tgcaagaata ttaaatagcc ccttccttaa ctgtacatat     4980

tatcttgaat gtagataaaa tgaaaatact gtaaattaga gtgtaggaaa actggcatag     5040

agttaatata ttttaatggg tttacattat actttaaaag taatttatat aattaaaata     5100

tttggtttta actctatggg ctattctttg gttggctgaa gagggaatgg gtctagtaag     5160

gtttggaaag ttaagctttg aacatggtct ttgtgttttt ttcctaacaa ggaaaggttt     5220

agttcagctg tgctatttta gtacacatca gttctcttga tttatggaag attcagttta     5280

tcaattaaga attcctgcag aagcacagaa tcataccatg taagagttgg aaggaagctt     5340

aagagatttc tgttcgaatc tctttgtttc aaagatgaaa ctaaagcaca gcatgttaaa     5400

tgacttgtct aagttatagc tagttagtag taaataaact gaaaacctat atgctactgt     5460

agtccaaaat tttattatgt cctcttaatc tttacattta gtgagtcagt aaggaaatct     5520

ctgcatattt ctcattctct ttgaaagagg aaaaaaactt ctaagagagc tacaactcta     5580

tcactcatga cagagttgct tgtagaaaat aactaattcc ttcagaaccc tgagtgaatt     5640

ttttctaaga aatgtgactt gattaaaatg gtttcaaaag agcaatagtg gaaattaaag     5700

ttttagaaaa gagacctggc gtggtggttg acaactgtaa tcccagtgct ttgggaggct     5760

gaggccagag gatcacttga ggccaggagt tcaagaccag cctggacaac atagcaagac     5820

ccccctctct acaaaaaaaa tttttttctg aaaagaataa gtacatttta gagtccattt     5880

atttgacgac aggcagtatg acaggttgct gaggtatata aaattttcta gagaaatgct     5940

gagtttgatg acattttatc ttcagttttg tagaacagat gttaaaatgt taactctcct     6000

ggtgtgcaga aagctgtaat catgacagtt gataatatgc aatttagttt gattttatag     6060

gtttaattat aaaaggcttc acaatatgca tgttttagga aaatgttcat ttatttagtc     6120

atataatcgt ttgtatatat gtaaataact ttattctgga ataatgtggg tgccatcttg     6180

agcgtgtgtt tttatctgtt ttggattatt ttttgtatac aaacaccata atactgtatt     6240

ttcctgttat ctacttaagt ctagttctac tttttcccaa taatttcagg aaaatacaag     6300

cttgagatat tatactatct cccttggtat tttttgtgtg caaagtctta gaattggatt     6360

tataacattg ataataaaaa tataaaacgt ttttcctcgg gagttaagat ggtaaaaaga     6420

aaaaaataga atgaatatga tcatttctcc atcataaagg aaagaagaga cttcattgtg     6480

tgtgtgtttt tttttttttt ttcgagatag agtttcactg ttgtcaccca ggctggtctc     6540

agctcactgc aacctccact tcctgggtac aagcgattct cctgcctcag cttcctgtgt     6600

agctgggatt acaggtgtgc aaccacaagg ctcggctaat ttttttgtat ttttagtaga     6660

gatggggttt caccatgttg gccaggctgg tctcgaactc ctgacctcaa gtgatccacc     6720

cacctcggcc tcgcaaagtg ctgagattac aggtgtgagc cactgtgccc agccgagact     6780

tcattgttta atgtatattt ttattttttc caaacaccag ctcgaatcag agtatatttt     6840

tattttgcca cataccttta aaaggtattt attgtgtcat aatgttttaa atgttaaata     6900

tatgataccc tcattcatga agtgaagcag aaagggtctg taaggaacat tctaaacatt     6960

tttaatgata ttgcttttac tgatcaagct tgttgtgcca tattaaaatt aaaagtcaaa     7020

taaacaaagc agtcctcaca gccttggaaa gaaatagata attgtcttct taagatgagg     7080

tgctttttat ctgtggatga atggaaatca cactgaattt taattcttat ttattttagt     7140

ggatagcagg aatcactctg tagtagttgt gttcattttc ttttcttttt cttttctttt     7200

ttttgagaga gtctcgctct gtcaccaggc tggagtgcag tggcgtgatc tcggctcact     7260

gcaacctcca tctcctgggt tcaagtgatt ctcctgcctc atcctcccga gtagctaaga     7320

ctacaggcac acgccaccat gcccagctaa tttttatatt tttagtagag atggggtttc     7380

accatgttgg ccaggatggt ctcaatctct tgacctcgtg atccacccag tttggcctcc     7440

caaagtgctg ggattacagg cgtgagccac tacacctggc cttgttcatc ttctaattaa     7500

atatctttga atgttttgta ataattttaa tgttgacaat aagagtttaa aaataatttg     7560

attttggact gtatttagat ttctctttaa ttttgctgta gaaatagtaa atgatttaaa     7620

gtggttatga tgtgttttat gaaggcttac tattttatat tgtacttatt taatttgtat     7680

ttgagtctgt ctaattttaa ataaaaggtt tatacatttg                           7720


<210> 985
<211> 1568
<212> DNA
<213> Homo sapiens

<400> 985
ggtggagccc gcgatggccg aacctgcgtc tgtcgcggct gaatctctcg cgggcagcag       60

ggcgcgcgct gcacgcacag tactaggtca ggtggtgctc ccgggtgagg agctgctcct      120

gccggaacag gaggacgcgg aaggccctgg gggtgcagtg gagcgaccgt tgagcctgaa      180

tgctagagcg tgctcgcggg tgcgcgttgt atgcggtccg ggccttcggc gctgtgggga      240

ccgcctgctg gtcaccaagt gcggccgcct ccgtcacaag gagcccggca gtggcagcgg      300

cggcggtgtt tactgggtgg actctcagca gaagcggtat gttccagtaa aaggagacca      360

tgtgattggc atagtgacag ctaaatctgg agatatattc aaagttgatg ttggagggag      420

tgagccagct tctttgtctt acttgtcatt tgaaggtgca actaaaagaa acagaccaaa      480

tgtgcaggtt ggagatctca tctatggcca gtttgtggtt gctaataaag acatggaacc      540

agagatggtc tgtattgaca gctgtggacg agccaatgga atgggtgtca ttggacagga      600

tggtctgctt tttaaagtga ctctgggctt aattagaaag ctattagctc cagattgtga      660

aatcatacag gaagtgggaa aactctatcc actggagata gtatttggaa tgaatggaag      720

aatatgggtt aaggcaaaaa ccatccagca gactttaatt ttggcaaaca ttttagaagc      780

ttgtgaacac atgacgtcag atcaaagaaa acagatcttc tccagattgg cagaaagttg      840

atataggtgg acttttttac aggtcagttg aggcaaaaaa ctatgggttt tttcaggtga      900

acctccccca tttaaatact cagaagataa ggtgtgaatg tatgtattat tagagtccga      960

aagtattttt ataagttact ggttttcacc cacgcttttg tgggagagaa aatcattgca     1020

aaatcatttt ttttgttcgg tacaataaag tttactaaaa aacagtatta gggtttattt     1080

ggagttaact cccttagtaa ttgctacagc ttccataatt aactggaggt cagcagtaaa     1140

ataattttgt gattataaca gtaagccagg ttcaccagag gaaatgtgga atacctaagt     1200

ataaagcagc aaagaaatgt cacctgtagt cccattattc agcgggtgag tatataacaa     1260

cgaaatactt tttcatttac caagtattgt gttttgcatg gattaactcc tttattctaa     1320

ctgcagaaga cacttatcct cataattgaa actgaggcac agaatttaac ttggcctaca     1380

ttctctatat tcatcaaatt gaaattatag ttattatagc ttatatgcca ctttgtaata     1440

tacttttgtc tacttcaaac agcatgatac atttcacaac tttagtcaca tatttcatgt     1500

tacaggatat ttttgagttt tatcattata taaataacac tatgaggatt tctgaatcca     1560

aatctggc                                                              1568


<210> 986
<211> 3478
<212> DNA
<213> Homo sapiens

<400> 986
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cggttgcttc      180

attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt      240

gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc tgtcgattga      300

ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt actgtgcttg      360

ctcctgactc tatgtcgcgt cttcaaggag aagaagtcct caccagtgaa cggagacctc      420

tctgaactaa ggataccatg gccacgtcag ccccactacg gagcctggaa gaggaggtga      480

cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt ggccacgtct      540

tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc gtctgcccac      600

tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg gccagcctgg      660

tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag gtgacccggg      720

agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac tactgtgagg      780

acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg      840

ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac cacctgagta      900

ccctaaggag ggacagagac aaaattcagg gcttccaggc aaagggagaa gctgatatcc      960

tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag tttgagcagg     1020

gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg aagctggagc     1080

aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag cttgcccggc     1140

tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca gagctcatgc     1200

aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt gggaaaccca     1260

ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc tctctgcaac     1320

gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag acagtgagcg     1380

tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac tggaagtgcg     1440

tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt gactgtgagc     1500

ctggggtgct aggcagcaag ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg     1560

agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag ggagaagagg     1620

aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa acggacgaag     1680

atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag gaagttctgg     1740

aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac ctctccctgc     1800

ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg gccaacacca     1860

gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc gccctggatt     1920

atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc tacaccttca     1980

ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca ggaacacgcc     2040

tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag atgcttcact     2100

tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag cacctggagc     2160

aggggacccc atatccactg gtagccacct ccccattgct gtggccccct gaaatctcac     2220

tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc ctgctggttt     2280

cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg accacgacct     2340

tggccccagc tctgcactct ctggaataag ggcccgatgc agcattttct tgcccagtgt     2400

ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt ccttaaaccc     2460

cccaggttcc ttcttgcaca aatccactct gctgcccacc ttccctggca ttttaaacag     2520

acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat aaacaaaatc     2580

cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat ctcatggggt     2640

ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat agccaaggag     2700

gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac acggctttgg     2760

ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg tgaggggagt     2820

tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca agacaaacat     2880

ccagtggagc agaacctctc ctgcctcggg agttctgacc gggttcccca gcagggtgtt     2940

aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag agagtggaga     3000

tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa     3060

gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca ggtgcccctc     3120

atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc agtcttgtcc     3180

ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc ctccaccctg     3240

ttctaagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac cattgtctca     3300

gagctgccca ctttgtgtgt gtcacatgct gcctgagtca catgtacatc ttatttctgc     3360

ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt gtattctcat     3420

ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt tgaatgaa       3478


<210> 987
<211> 1963
<212> DNA
<213> Homo sapiens

<400> 987
gcagagccgc tcccgaggcc ccggcgcggc gcgagggcgc ggggcgcggc gtccacaggc       60

gccgaggctg cccccgccgc cccgcccgcg aagatggcgg cggaactcta cgctcccgcc      120

agcgccgcgg ccgcggacct agccaacagc aacgccggcg ccgccgtggg caggaaggcc      180

gggccgcgca gcccgcccag cgcccccgcg ccagcgccgc cgccgcccgc gcccgcgccg      240

cccacactcg gcaacaacca ccaggagagc cccggctggc ggtgctgccg ccccacgctg      300

cgcgagagga acgcgctcat gttcaacaac gagctcatgg ccgacgtgca cttcgtcgtg      360

gggcccccgg gggcgaccag gacggtgccc gcccacaagt acgtcttggc tgtcggcagc      420

tccgtcttct atgccatgtt ctacggagac ctggcggaag tcaaatctga aattcacatt      480

ccagacgtgg agcccgcagc ctttctgatc ctcttaaagt acatgtacag tgatgagatc      540

gatctggaag ccgacacggt gctggccact ctgtacgctg ctaagaagta catcgtccca      600

gcattggcaa aagcctgtgt caactttctg gagacaagtt tggaagccaa gaacgcctgc      660

gtcctgctgt cccagagccg gctgtttgag gagcccgagc tgacgcagcg ctgctgggag      720

gtcattgacg cacaggccga gatggcccta cggtccgaag gcttctgtga gatagaccgg      780

cagacgctgg agatcattgt cactcgggag gccctcaaca ccaaagaggc ggtggtcttc      840

gaggccgtcc tgaactgggc cgaggcggag tgcaagaggc aggggctgcc aatcacccca      900

cgaaacaaga ggcatgttct ggggcgagcc ctctatctgg tccgaattcc aaccatgacc      960

ctagaggagt ttgccaacgg cgctgcccag tcagacatcc tgactctgga ggagacccac     1020

agcatcttcc tgtggtacac ggccaccaac aagccccgcc tggactttcc cctgaccaag     1080

aggaagggcc tcgccccgca gaggtgccac cgattccagt cttctgccta ccgcagcaac     1140

cagtggcggt accgcgggcg ctgcgacagc atccagtttg cagtggacag aagggtattt     1200

attgcagggc tgggcctgta tggctccagc tctgggaagg ctgagtacag cgtgaagatt     1260

gagctcaagc ggctcggggt ggttctggct cagaacttga ccaagttcat gtcagacgga     1320

tccagtaaca ccttcccggt ctggtttgaa cacccggtcc aggttgaaca agacaccttc     1380

tacacggcca gtgccgtcct ggacggcagc gaactcagct actttgggca ggaggggatg     1440

acggaagtgc agtgtggaaa ggtggccttc cagttccagt gctcctcgga cagcaccaac     1500

gggactgggg tccagggtgg gcagatccct gagctcattt tctatgcctg aggtgcccgg     1560

ggaggctgca gcaggtcagc gagtgagtgg aggggaagtc aagatgctaa ctgcttcttg     1620

acaccatgaa aggctgctct taactttgtc tctctttgac atgtagtcag ctgaagcttg     1680

actgtgtaga gacattttcc acacagccag aacccaggga ttggagtctt aggcatctct     1740

ggtacagtgg ggtgcacgtc tcaggtggag gaagatttac ggctcaagac aggccccaga     1800

tcccctccca gtggcaccca tgccacctgc tttgaggggt tggatcttcc tgctaccctc     1860

ttggattcta agtggttcca agcttaactt gagaccttcc cttcaaatct aaaattggca     1920

aaaagtcact taaaatagtg gacttctgta ataaaggttg cct                       1963


<210> 988
<211> 3760
<212> DNA
<213> Homo sapiens

<400> 988
atgcgcgccc tggcggccct gagcgcgccc ccgaacgagc ggctccttcc ccgggacccc       60

gcggctaccc gggaccccga cgccgcgcgg ccggcgcgca ggagcgcagt ggagaggctg      120

gcggcggatc gcgccaagta tgtgcggggt cggccgggga ctggccgggg cgtcgcttcc      180

gagggcagcg gcccgggggc gatcaagtgc ccggggaacg accctgggcc cccggcccgc      240

gccccggccc cggtggcgcg cagggctatt gcgcggaagc cgttgagacc ggactcgctg      300

atcatctacc ggcagaaatg cgaattcgtg cgaggatcgg gcgccgacgg ccccagggca      360

agcctggtga agaagctctt ccaggggccg ggtaaggaca aggcgccggt gccccggacg      420

ggagacgagg gcaaggccgg gaacccggag acggtcccga ccactcctgg ccccgcggcg      480

gaccccgcaa tccccgagac cccagcccca gccgcgcggt ccgcggcgcc ctccagtgtc      540

ccggccgcgc cccctgggcc agagccgcgg gtggtgaggc gtcgggggct gcagcgctca      600

cagtcggacc tcagctcccg ctattccgct gccttggccg agtctgacac cttcttccag      660

tactgcggcc tggaccccga ggtggtggag gccctgggga gggagaactt caccgcgggg      720

tcggactgtg tgaccctcaa ggtgcgcagc gtgagcgtcg ccacctccgg cagcggcttc      780

tcccggcaca gcggcggcga cgacgagggg ctgcaggagg aggagctgat agagcaggtg      840

cccagcacca cttcggtcat cgagaggaac gcccgcatca tcaagtggct gtacacctgt      900

aagaaggcca aggagacccc cagccaggag cagagccgga cccgaggaag caaaccttcc      960

cgatgatgaa gacttcttga aggatttcat gggtgatttg ggatcccagg accatttggc     1020

tagtgtgcct aggtgaccac atgattgctg ttttaccagg aatgcagcat cccattgaca     1080

aaacaagtgc tctgagaagg tttaaaatac tacagagaat atgggaacac agaccttgaa     1140

atttagctga gttgtaacag ctgaaactcc aagaggtgtc ttccttgttt gaggtgaaac     1200

tagtgttgct tccagagggc agctggaaac cgtaaagctg tttggaaatc tttttgactg     1260

acttgctgac aaagaggtac tgtgatgcat tttaacaata tctaagttga ttttttttta     1320

aatcaaggaa aataaaaacc aagcatgaat gctatggtat gtgccccttt tgaccatcct     1380

gggctgatta acatcattta aatcaaagta atcataaaaa ggcatattct acttcaatta     1440

tgtggtcaaa taagagtaaa cacacacact cacacatgct gaccccaatt gccagagcat     1500

tactgcacta taaattacgg ttaattccca aattatacta ctgtttatct tatttaacaa     1560

gtcagaaagc acttttaaaa taacttgagg gctacaaggt cattctatta atgtcattct     1620

ccattcgggt tgtaggcatg tggaagtacc cattaaaaga taagttagag tttaaatact     1680

gataaacaaa accttttatt gcaactggac agtttctgga gagttagcgg aagaatcttg     1740

gagtttcctt tggtcagatg aatacaacat ttcacttttg cagcactatt tagaatgtac     1800

tccatggttc tcttgttccc aacttccaaa aagaacagaa aactttggtt tacacagaac     1860

acgggcatct gaggcaggac ctcttccctg ccctttgatc tgactcacac ctccacatat     1920

gacgtaatca acccaaattt gacaccaatt cactcttttc tgcaaagggc atattttgaa     1980

acaagggaca gcctgagggc ggctataatg agaatgttca tgggggttac tgggtcccta     2040

attctgaact tgcttatgac acccagagtg aatagattca gattcagaac cttctgagaa     2100

ataacccaaa gaaaatttgt tacccagcca attcttcgaa agcttaatat caaaatatat     2160

cttttcaaga agaaaatcgt tagagagaag aatgtggagg ggagagaaat gggtttctca     2220

ttgatatgat attttgttaa ccatttcatt ttgaattatt caagttttgg ttaatattgt     2280

attctttttt cgtaactatt ttaccgtgag agtaggtcat tgggttactt agatatttat     2340

ttttacacag ttattagtct tcagatagtt ttattttact tcatatgatt ttagtttttg     2400

tcagtataat tttaaatcat gtttttcttg gtcatctctt tgtgtatatt gtgtaattgg     2460

attttcattg actgcaagtg gagtgtttgc cactcaattc agtactcagt actatggtga     2520

cttgttttca aataagtctc agatacacat ttagggagcc tttgctggcc gaatatagac     2580

tctgtcagga cagcaggtcc cctgatctaa gaattttccc caatggttgc tctaaaaatg     2640

ctgctatttt gctgttcact gtattgcact tagttaaaaa gaagataatg tgaaagatga     2700

gagcagtttt ttaaaggatc ttttcatata cccaattccc ttattttcag atgtcccatc     2760

aattttagat atgaaagctt taagtaaaag tgtgtatgcc tttctactgt cagaacagga     2820

tggatgcagc ctgggtcaga tttatttaag ataaaaatca tgcagactca tcattcatat     2880

cataggtgaa aaatgtaaaa accaaatggt ttccactaaa gccaccaaga tcttttagaa     2940

atgtttgcac ctttggtggt ggcacaggaa aagagaagaa ttcagctgga gtgaattcta     3000

gaagtagata tcagaaacgg ggcatgaaga acaggggaac tgggtggcat cagactccta     3060

aagaagtgag ttaattttcc ttcccttcca ttcagattca tgccacagct ccatatcttg     3120

agtatgtgta agaggtgagt tccttcttca gccaggggcg gtggctcatg cctttaatcc     3180

caatgctttg ggaggccaag gtgggaggat cacttgtgcc ttggggttca aggttgcagt     3240

gaaccatgat tgcaccactg cactccagcc tgagtgacag agcaagaccc tgtctctaaa     3300

aatatatata aaaagtaaaa ctaaagaact tcttgcctaa acctgaatta ccgcaatttg     3360

ctgagtgact ttgagaaaaa tcagactgtt tagttcagtc gggatgaaaa gcttgcgatt     3420

gcttcccaca agaatgggca atagtgacgg ctgcaaggta cttttatttg ttcatgaaag     3480

aacgacaatt tttcaaaatg taattaaaca taatagaatg ttttaaacta ctgggcactg     3540

aaactggaag aaaaaggagg ctttattgaa cattcccctt tttcagttgg ttcaaagttc     3600

agcactgtgg ttatcattgg tgatgccaga aaacattagt agacttagac aattgctatg     3660

gcagtttcta aacagagctt tttctataca ctatttgcaa ctggagtgca atattgtata     3720

ttctgtgtta aagaaataaa gtatttttat catttattaa                           3760


<210> 989
<211> 1374
<212> DNA
<213> Homo sapiens

<400> 989
ggacagcttg gagatagggc ccggaattgc gggcgtcact ctgctcctgc gacctagcca       60

ggcgtgaggg agtgacagca gcgcattcgc gggacgagag cgatgagtga gaacgccgca      120

ccaggtctga tctcagagct gaagctggct gtgccctggg gccacatcgc agccaaagcc      180

tggggctccc tgcagggccc tccagttctc tgcctgcacg gctggctgga caatgccagc      240

tccttcgaca gactcatccc tcttctcccg caagactttt attacgttgc catggatttc      300

ggaggtcatg ggctctcgtc ccattacagc ccaggtgtcc catattacct ccagactttt      360

gtgagtgaga tccgaagagt tgtggcagcc ttgaaatgga atcgattctc cattctgggc      420

cacagcttcg gtggcgtcgt gggcggaatg tttttctgta ccttccccga gatggtggat      480

aaacttatct tgctggacac gccgctcttt ctcctggaat cagatgaaat ggagaacttg      540

ctgacctaca agcggagagc catagagcac gtgctgcagg tagaggcctc ccaggagccc      600

tcgcacgtgt tcagcctgaa gcagctgctg cagaggttac tgaagagcaa tagccacttg      660

agtgaggagt gcggggagct tctcctgcaa agaggaacca cgaaggtggc cacaggtctg      720

gttctgaaca gagaccagag gctcgcctgg gcagagaaca gcattgactt catcagcagg      780

gagctgtgtg cgcattccat caggaagctg caggcccatg tcctgttgat caaagcagtc      840

cacggatatt ttgattcaag acagaattac tctgagaagg agtccctgtc gttcatgata      900

gacacgatga aatccaccct caaagagcag ttccagtttg tggaagtccc aggcaatcac      960

tgtgtccaca tgagcgaacc ccagcacgtg gccagtatca tcagctcctt cttacagtgc     1020

acacacatgc tcccagccca gctgtagctc tgggcctgga actatgaaga cctagtgctc     1080

ccagactcaa cactgggact ctgagttcct gagccccaca acaaggccag ggatggtggg     1140

gacaggcctc actagtcttg aggcccagcc taggatggta gtcaggggaa ggagcgagat     1200

tccaacttca acatctgtga cctcaagggg gagacagagt ctgggttcca gggctgcttt     1260

ctcctggcta ataataaata tccagccagc tggaggaagg aagggcaggc tgggcccacc     1320

tagcctttcc ctgctgccca actggatgga aaataaaagg ttcttgtatt ctca           1374


<210> 990
<211> 4311
<212> DNA
<213> Homo sapiens

<400> 990
gctggaggct cagcgcgcaa gcgtgcgcgt gatttggccc tgaacggacg ccgtagccaa       60

gaggttgggc ggatgttgtg agccgggtcg ctgcggccga ggctccggcc cccaggacca      120

ctggctgccc atgagagatg aaggatggca tccaaggggg ccggcatgtc tttctcccgc      180

aagagctata ggctgacctc agatgctgag aaatccaggg tcacaggcat tgtgcaggag      240

aagctgctga atgactacct gaaccgcatc ttttcctctt ctgaacatgc acccccagca      300

gccaccagca ggaaacccct gaacttccag aacctgccag aacatttgga ccagttgcta      360

caggtggaca atgaggagga ggaaagccag ggacaggttg aagggcggct tggcccatcc      420

actgtggtcc tggaccacac aggcggcttt gaggggcttc tcctggtgga tgatgacctg      480

ctgggggtga ttggacacag caactttggc accatccgct ctaccacatg cgtgtacaaa      540

gggaaatggc tctacgaggt cctcatctcc tcccaggggc tcatgcagat cggctggtgc      600

accatcagct gccgcttcaa ccaggaggag ggggttggag atacacacaa ctcctatgcc      660

tatgatggca accgcgtgcg caagtggaat gtgaccacaa cgaattatgg caaggcgtgg      720

gcagcggggg acatcgtgag ctgcctgatt gacctggatg atggcactct gtccttctgc      780

ctgaacggtg tatcactggg cactgccttt gagaacctgt ccaggggcct gggtatggcc      840

tacttcccag ccatcagcct ctctttcaag gagtccgtgg ccttcaactt tggcagccgt      900

cctctgcgct acccagtggc aggctaccgg cccctgcagg acccaccgag tgctgacctg      960

gtgcgggcac agaggttgct gggctgcttc cgggcagtgc tgagtgtgga gctggaccct     1020

gtggaggggc ggctgttgga caaggagagc tccaagtggc ggttgcgggg ccagcccacc     1080

gtcctcctca cactggccca catcttccat cactttgcac cgcttctgcg caaggtgtat     1140

ctggtggagg ctgtgctcat gagcttcttg ctgggcatcg tggagaaggg cacacccaca     1200

caggcacagt ccgtggtgca ccaggtcctg gacctcttgt ggctcttcat ggaggactac     1260

gaggtacaag attgcctcaa gcagttgatg atgtctctgc ttcggctgta ccgattctca     1320

cccattgtcc cagacctggg cctacagatc cattacctgc ggctcactat cgccatcctg     1380

aggcatgaga agtcccgcaa gtttctgctt agcaatgtcc tcttcgacgt gctccgctcc     1440

gtcgtcttct tttacatcaa gagccccctg cgtgtggagg aggccggcct gcaggagctc     1500

attcccacca cctggtggcc ccactgctcc agtagggagg gcaaagagag cacggagatg     1560

aaggaggaga ccgcagagga gcggctgcgg cggcgagcct acgaacgggg ctgtcagcgg     1620

ctcaggaagc gcatcgaagt ggtggaagaa ctacaggtcc agatcctgaa gctgctgctg     1680

gacaataaag atgacaatgg gggtgaagct tctaggtata tcttcctgac caagtttcgc     1740

aagtttctgc aggagaacgc cagtggccgg gggaacatgc ccatgctctg cccccctgag     1800

tacatggtct gcttcttaca ccggctgatc tctgccctgc gctactattg ggatgaatac     1860

aaggcttcca atcctcatgc ttccttcagt gaggaggcct acatcccgcc ccaggtcttc     1920

tataatggca aggtggacta ctttgacctg cagcgcctgg ggggcctcct ctcgcacctg     1980

cggaagaccc tcaaagatga ccttgcttcc aaagccaaca ttgtgatcga cccactggag     2040

ctccagtcaa ccgccatgga tgacctagat gaggatgagg agccagcccc agctatggcc     2100

cagcgcccca tgcaggccct ggctgttggg gggccactgc ccctgccccg gcccggctgg     2160

ctcagttctc caactttggg ccgagccaac cgcttcctca gcacagcggc tgtgagcctc     2220

atgaccccac ggcggcctct gagcacctcg gagaaagtga aggtccgcac gctgagcgtg     2280

gagcagagga cccgtgagga cattgaaggc agccactgga atgagggctt gctgctgggg     2340

cggccccccg aggagcctga gcagcccctc accgagaact cgctgctgga agtcctggat     2400

ggggcggtca tgatgtacaa cctcagcgta caccagcagc tgggcaagat ggtgggtgtc     2460

tccgatgatg tcaatgaata cgctatggct ctgagggaca cagaggacaa gctccgccgg     2520

tgccccaaga ggaggaagga catccttgca gagttgacca agagccagaa ggttttctca     2580

gaaaagctgg accacctgag ccgccgtctt gcctgggtcc atgccactgt ctactcccag     2640

gagaagatgc tggacatcta ctggctgctg cgcgtctgcc tgcggaccat tgagcacggt     2700

gatcgcacag ggtctctctt tgccttcatg cccgagttct acctgagcgt ggccatcaac     2760

agctacagtg ctctcaagaa ttactttggt cccgtgcaca gcatggagga gctcccaggc     2820

tatgaagaga ccctgacccg cctggctgcc attctcgcca aacactttgc cgacgcacgc     2880

attgtgggca ctgacatccg agactcactg atgcaggccc tggccagcta cgtgtgctac     2940

ccacactccc tgcgggctgt ggagcgaatc cccgaggagc agcgtatcgc catggtgagg     3000

aacctcctgg cgccctatga gcagcggccc tgggcccaga ccaactggat cctggtgcgg     3060

ctctggaggg gctgtggctt cgggtaccgc tatacacggc tgccacatct gctgaaaacc     3120

aaacttgagg acgccaattt gcccagcctc cagaagccct gcccttccac cctgctgcag     3180

cagcacatgg cggacctcct acagcagggt cctgatgtgg cacccagctt cctcaacagc     3240

gtcctcaatc agctcaactg ggccttctct gaattcattg gcatgatcca agagatccag     3300

caggctgctg agcgcctgga gcggaacttt gtggacagcc ggcagctcaa ggtatgtgcc     3360

acctgctttg acctctcggt cagcctgctg cgtgtcttgg agatgactat cacactggtg     3420

cctgagatat tccttgactg gacccggcct acctctgaga tgctgctgcg gcgtcttgca     3480

cagctgctaa accaggtgct gaaccgggtg acagctgaga ggaacctgtt tgatcgtgtg     3540

gtcaccctac ggctgcctgg cctagagagc gtggaccact atcccattct ggtggcagtg     3600

acgggcatcc tggtgcagct cctggtgcgt ggcccagcct cagagagaga gcaagccaca     3660

tcagtgctcc tggcagatcc ctgcttccag ctacgctcaa tatgctatct cctgggacag     3720

ccagagcccc cagcacctgg cactgctctg ccagcccctg accggaagcg cttctccctg     3780

cagagctatg cggattatat cagtgccgat gagctggccc aagtggaaca gatgctggcg     3840

cacctgacct ctgcatctgc ccaggcagca gctgcctccc tgcccaccag tgaggaggac     3900

ctctgcccca tctgctatgc ccaccccatc tctgctgtgt tccagccctg tggccacaag     3960

tcctgcaaag cctgtatcaa ccagcacctg atgaacaaca aggactgctt cttctgcaaa     4020

accaccatcg tgtctgtaga ggactgggag aagggagcca atacgagtac tacctcctca     4080

gctgcctagc cctcacagcc tgtgccatcc tggaacctcc acctttgaac ccagagccag     4140

gctgggccct atttatgagc tccctttgcc cttctcctgt atcccacacc accacatcca     4200

acctccttgc ctgcctgtat cctcattggt gggagcccag ccatggccct aattgtgcct     4260

gagcttgact ttcagtcagg gccacagtga gcattaaatt attattccat a              4311


<210> 991
<211> 3627
<212> DNA
<213> Homo sapiens

<400> 991
gccgccgcgc ggccggggct tctcactctg acgggcccgc gcgcacgatg gccggcgccg       60

cgccgcgggt ccgctacctg gcgggcttct gctgccctct cgggggcctg gcggcgggca      120

agccccgcgt gctgtgccat gaggcagagg tcttcctgtc caccgggagc gagctcgtct      180

acgtgtacga ccaggagggc gggctgctga ccgcggcgtt ccggttcccc gaccaggtgt      240

ggcacctgga gctgctggcg ccgcgcaggt tgctgtacgc gctgtgcgcc cggaggggcc      300

tctactgcct gtcgctggac cacccgggca ggagcaggtc tacgagccag gatgacaggg      360

acagcgagga cggtgaccag ccttcccccg tgatccctgt ggaccccgat gcctgcatcc      420

ttcccgatgc tgcgctgtgc gcgttcacct tgctggacag tgtgctggtc accctggtgc      480

agggccctgc ccgatggaag atgcagctgt ttgagcagcc ctgtcctggg gaggaccccc      540

ggccaggagg ccagatcggt gaggtggagc tgtcctccta cacgccccca gccggggtcc      600

caggaaagcc tgcagccccc cacttccttc cagtgctgtg ctctgtgtca ccatcaggct      660

ccagggtccc gcacgacctc ctcgggggct ccgggggctt cacgctggag gacgccctct      720

tcgggctcct ctttggagct gatgccaccc tcctgcagtc acctgtggtc ctctgtggtc      780

tccctgatgg ccagctctgc tgtgtgatcc tgaaggccct ggtcacctcc aggtcagccc      840

ctggtgaccc aaatgccctt gtcaagatcc tccatcacct ggaggagccc gtcatcttca      900

taggggcctt gaagacagag ccacaggctg cagaagctgc agagaatttt ctgcctgacg      960

aggatgtgca ctgtgactgc ctggtggcct ttggtcacca cggccggatg ctggccatca     1020

aggccagctg ggatgagtcc gggaagctgg tgcccgagct gcgggagtac tgcctcccag     1080

gccctgtgct ctgcgctgcc tgtggcgggg gtggccgcgt gtaccacagc accccttctg     1140

acctctgtgt ggtggatctg tctcggggaa gcaccccgct gggccctgag cagcccgaag     1200

aaggcccggg aggcctgccc cccatgctgt gcccagccag cctgaacatc tgcagtgtcg     1260

tctcgctgtc cgcgtctccc aggacgcatg aaggtggcac caagctcctg gccctgtccg     1320

ccaaaggccg cctgatgacc tgcagcctgg acctggactc tgagatgcct ggcccagcca     1380

ggatgaccac agagagtgca ggtcagaaaa taaaggagct gctgtctgga attggcaaca     1440

tctctgagag agtgtctttt ctaaagaagg cggttgacca gcggaacaag gcactgacaa     1500

gcctcaacga ggccatgaac gtgagctgtg cactgctgtc aagcggcacg ggccccagac     1560

ccatctcctg caccaccagc accacctgga gccgcctgca gacacaggat gtgctcatgg     1620

ccacctgcgt gctagagaac agcagcagct tcagcctgga ccaggggtgg accctgtgca     1680

tccaggtgct caccagctcc tgtgctctcg acctggactc ggcctgctcc gccatcacct     1740

acaccatccc cgtggaccag ctcggccccg gtgctcggcg ggaggtgacg ctacccctgg     1800

gccctggtga gaacggcggg ctcgacctgc ccgtgaccgt gtcctgcacg ctgttctaca     1860

gtctcaggga ggtggtgggc ggggcccttg ccccctcaga ctctgaggac ccctttctgg     1920

atgagtgccc ctccgacgtc ctgcccgagc aagagggtgt ttgcctgccc ctgagcaggc     1980

acacagtgga catgctgcag tgtctgcgct tccctggcct ggccccgcca cacacacggg     2040

ccccctcccc actcggcccc acccgagacc ctgtggccac ttttctggaa acttgtcggg     2100

agcctggcag ccagccagca ggacccgcct ccctgcgggc cgagtacctg cccccatctg     2160

tggcttccat caaggtgtcg gcggagctgc tcagagctgc cttgaaggac ggccactcag     2220

gcgtgcccct gtgctgtgcc accctgcagt ggctccttgc tgagaatgct gctgtggacg     2280

tcgtgagggc ccgagcacta tcttccatcc agggagtggc ccctgatggc gccaacgttc     2340

acctcatcgt ccgagaggtg gccatgactg acctgtgccc agcagggccc atccaggccg     2400

tggagattca agtggaaagc tcctctctgg ccgacatttg cagggcgcac catgccgttg     2460

tcgggcgcat gcagacgatg gtgacagagc aggccaccca gggctccagc gctcctgatc     2520

tccgtgtgca gtacctccgc cagatccacg ccaaccacga gacactgctg cgggaggtgc     2580

agaccctgcg cgaccggctc tgcacggagg atgaggccag ctcctgtgcc accgcccaga     2640

ggctgctaca ggtgtaccgg cagctgcgcc accccagcct catcctgctg tgaccaggcg     2700

ggcctgcccc tgggctctgg ccacgcttcc agcctctgtc acagcccccc caggcctcat     2760

gggttagagg gaaaccgagc tggcctggcc agagccgtca gggaaggtag gacctggcca     2820

cgtaggagca gaacgctcat gaaagtgctt ggaggccgtg gagcacaaag cagattctga     2880

ttgggagcaa ccgaggcggg ctctgaacct ggccggtcca gcttcgcgtc ctctgctggt     2940

gtctctcctt ctctgaccgc ggccgcagcc cctgcactcg ccttcctcac tgctgggcag     3000

ccttcccacc accgcagcag cccctgaggc caggaggcag tgcagggcat tctggacccg     3060

gagggccaga gaaacaggat ttctggggtt tggacttggg gtgagtttgt aactgttgct     3120

gccacaccac caggagcacc ggctgcccct ctgggtggca ctaccaggtg ccccacggta     3180

cccttgtcac actgttcaca cctgcccggc tgcccactct gggaccccga ggtaggaggg     3240

tgctccctga gaccaaagca caaaacagca tgcagggagc tcctgcaagt gcccgtggtc     3300

tcgtgccaca ccaaggaagg gccagcgggt ggcctgtggc cggaatgctc aacaactagg     3360

tgcctccagc cggggcagta cccagcactg tgcactattt tcagggccac tcagggtggc     3420

gctgtggccc gggggggggc cctgagcccc agcccccagc ctcctccctc agcctgggct     3480

acggcccacc tcctggtgct ggtgttttca tctggggagg gtgctcgcgc cgctcccgct     3540

gcaggcactg tccgcgatga gtgcgggtag gagccgtgag gtgcttctct gctgtgacaa     3600

acgaccctgt ctgtccgtga accttca                                         3627


<210> 992
<211> 4024
<212> DNA
<213> Homo sapiens

<400> 992
attatcctcc ttattgacaa acagagcggt cgcggcggcg actctcggcg tgcggtgata       60

gccaagccat gggagacaag aagagcccca ccaggccgaa gcggcagccg aagccgtcct      120

cggatgaggg ttactgggac tgtagcgtct gcaccttccg gaacagcgcc gaggccttca      180

agtgcatgat gtgcgatgtg cggaagggca cctccacccg taaagagaaa aaagataaag      240

tagaaaaaga aaaaagtgaa aaggaaacaa ctagcaaaaa gaatagccat aagaaaacca      300

ggccaagatt gaaaaatgtg gatcggagta gtgctcagca tttggaagtt actgttggag      360

atctgacagt cattattaca gactttaagg agaaaacaaa gtcaccgcct gcatctagtg      420

ctgcttctgc agatcaacac agtcaaagcg gctctagctc tgataacaca gagagaggaa      480

tgtccaggtc atcttcaccc agaggagaag cctcatcatt gaatggagaa tctcattaaa      540

gtttattttc tccaatttct tagtcacttc tgtcctacca tgcaaataca cagattatgc      600

caagaggtac cacattttca tgacagatac attcatgcac aatccataat ttgagtttta      660

cataaaatag aaatttgtta gaatttgtta gattttattg caatgatgcc taccaaacat      720

ttccagactt aacattttgg tctctgcagt taagtgccat gaaaatgtgg ttgaattatt      780

cattatgcag tgttattggt aagtgtattt tcacttttag tttagtgaat tctaacacat      840

aattcttgaa ttctctacta ttggcatgta acgaatttaa attttttata acatagtgca      900

agctgcctaa atatgtatta tttgagaatt gtgaaacaga tagttatatg tatacaagtc      960

aaagaacaac ttaactattg ctgcaacagg tttttcttaa tggttatcct cttaaataca     1020

cctgctggta cttggtgtgg ttaaatagga aaattgttat taaataaaga atttgtatga     1080

acctttgcca atgtttttga cacgttttac taattattgt tcctgaatta tgtttctggt     1140

tttatctatt ttttgaggtt tttttgtttg cttatttttc aaaacattca tttattgtaa     1200

tgtttactag cggactagta aacaataaaa cattgattat ttagctttat aattcaggtt     1260

tagtgctatt gtcattgaac actggtattt tctgtatcat ataaaacatt aaaattcaaa     1320

taattataag catttggcaa aaacaagaga aaagaaactt gccatatttt acaagctgca     1380

attttagaaa agctttaact taatgatagt tttatcattg ttttcttgtc ccaaacttat     1440

ccagggccat agaagtatga atctaattaa aacagaaatg ggaattattg cacagaaatg     1500

ggaaataact aattttaaat cagtcaaatt ggcttcttat taaatacaat aattcttatg     1560

aaaatcatag taccctattt tcagacacag ctgccagttt acacatttct cagtatcctg     1620

aaaggaaaaa agtatagccc cacttatact atgtaaaatt accaataaaa tatttttatg     1680

actacagatt ttgcattttt gtttacaact atttaaagag ttttatgttg tatttagaat     1740

ttcaacctag aaaccacaca gtacttaaat tctcctgggg tctcctgctt tctcttaacc     1800

atttgcttaa tatatatcta cctaaaggag acttctgaat tgtaaatgaa cttaaaaata     1860

gaatgtggat gcaaaatatc acataagaca tcatgataac atttgaagaa aaaataaaac     1920

tgtagaccct aacagttgtg atatttggtg gtttcatgtg gtaatgtaat tttctgttta     1980

attacagtac tttttacagg cacagtggta ctgtcttttt tgtaagatgc tagttgtgaa     2040

atacaattaa ttgcatacag taaaagtctg tgattaaaac atttatatac ctcattcttt     2100

agtgttgtta aatgaaaaat taaaatttgt gtttattata agatactttc aatggaatac     2160

cagctaacca gatatgttcc tttaaaacat gaattttttt gtcttattct gtttttaaca     2220

tgtttcaaat gttttataca tttttggaga tagtaaaaat ttaaaaatgt aatagggaaa     2280

atatttaatt tttaagtcaa aaactatgct ttaaaggaat tacatcttat gatcaaataa     2340

ctttcaggat gtattttaaa tgagctgcaa gagagaaaaa tctgacagga gatgggattt     2400

tacctgaatg gagcatactc atatttctac ataggtggga agatactcat ctttctacat     2460

agacgggaac acggtgtagc atggagatta agcgtgctaa ctgacacctc atgtttgaat     2520

cctgttgtag aatggaaatg agcttaaatt acccaagctt actttccatc tataaaacag     2580

ggctaataat ggtaatcaca tctaatttat agggtttttg ggaggattaa gtcaatccgt     2640

gtaaaattct taattatctg acacatactg gtcactcagt aaatgtgagc ttttaccatt     2700

gttataggta aaatcccatt acaaaaatac aaaaatattt tttgtaacag ttattttcct     2760

gccctcttgg atgacctaaa gtaatagtgt tttatagatt tcactaaatt ttcagtgtaa     2820

tatcagatgt tttctctgga tgcagaaaga ccatctttcc ataattaaag aacctggtgg     2880

gtgtgcacta tgagattgga gaaatgaatt aagttgactt gaaattattt tacttttatt     2940

aatcacaggt atctcaacct gcctttgttt caccctactt caagtacact tccacaccag     3000

gaaaacagac ccaaattcca taaacagaac tgacgttaaa atatgcgaaa gattcagaac     3060

ctaggtttag ggtacatgtt tttctctgtt tcatgaactt acagtgtggt ttgagcactg     3120

ggttctttta gccaaattcc atacaaaaag aatttggatg ttttccagca tttattacct     3180

tactttgcta taagtaagag tgaagatagg ccgggtgtga tggctcatgc cagtaatccc     3240

agcactttgg gctgaagcag gcagatattt tgagcccagg accagcctgg gcaacatggt     3300

gaaagctcat ctctatgaaa aaatttgaat atacatatat atatatatgt atatttaaaa     3360

agtgaatata atttgaggca cagaagaata ttcttaaaac cttttgtatt atacaataga     3420

aataaaggtt ttatttttat taaatgcttt cctaaaatga tagtggataa tagacaaagt     3480

gaaaacattt aaaaaggaag agaaacttca gcctttctaa gttgatagca tgtttattaa     3540

cttttagata aagatcctta tagactgaaa gaatgtagcc tctgcattaa tggtaaatgg     3600

tctagaagtt ttcgtttcca ctgaggcttc cgccactcgc ttttttaaac ttcctgctat     3660

ggtttggata tggtttgtcc tcaccaaaac tcatgctgag gcctgagtcc ccagtttgat     3720

tgtgttggta ggtggtgcct ttaagaggtg attaggtcat tgagatggat taaaggcttt     3780

ctcatgaggc tcagttagtt ctggaatgga ttcgctcttg caggaatgga tgaattctca     3840

caagagtggg ttgttatgaa gtgaggatgc ttcttgtgtt ctgttctctt tgccctcctc     3900

agttcaccat ctgctttcca ccatgagttg aagcagcatg aggccctcat cagatgggct     3960

ccctgatctt ggactcctca gcctttggac tcataagcca aaataaatct gttttcttta     4020

taaa                                                                  4024


<210> 993
<211> 3490
<212> DNA
<213> Homo sapiens

<400> 993
cagagagaga aggtaaacca agggaacatg ccagggcttc agagcacctt cctagccatg       60

gacacggagg agggggtaga ggtggtgtgg aacgagctcc acttcggaga caggaaggcc      120

ttcgcggcgc acgaggagaa gatccagacc gtgttcgagc agctggtgct ggtggaccac      180

ccgaacatcg tgaagttgca caagtactgg ctggatacct ctgaggcctg cgcgagggtc      240

atcttcatca cagagtacgt gtcatcaggc agcctcaagc aattcctcaa aaagaccaag      300

aagaaccaca aggccatgaa cgcccgggta tggggagcgg gctggggcag ccacggggac      360

aggacggggt tggggcagcc tcggggactg ggatggtgag ggggtgcccg gcggcctcgg      420

acaggggctg ggcgaggatg cggggcgggc tccgcaggcc cagccgcctc tcctgcgccc      480

acccgaccga cggagtcgtg cgtccgccgc caggcctgga agcgctggtg cacgcagatc      540

ctgtctgcgc tcagcttcct gcacgcctgc agccccccaa tcatccacgg gaacctgacc      600

agcgacacca tcttcattca gcacaacggc ctcatcaaga tcggctccgt gtggcaccga      660

atcttctcca atgcacttcc agatgatctc cgaagcccca tccgcgctga gcgagaggaa      720

cttcggaacc tgcacttctt ccccccagag tatggagagg tggccgatgg gaccgctgtg      780

gacatcttct cctttgggat gtgtgcgctg gagatggctg tactggaaat ccagaccaat      840

ggggacaccc gggtcacaga ggaggccatt gctcgcgcca ggcactcgct gagtgacccc      900

aacatgcggg agttcatcct ttgctgcctg gcccgggacc ctgcccgccg gccctctgcc      960

cacagcctcc tcttccaccg cgtgctcttc gaggtgcact cgctgaagct cctggcagcc     1020

cactgcttca tccagcacca gtacctcatg cctgagaatg tggtggagga gaagaccaag     1080

gccatggacc tgcacgcggt cttggcggag cttccccggc cccgcaggcc cccgctgcag     1140

tggcggtact cggaagtctc cttcatggag ctggacaaat tcctggagga tgtcaggaat     1200

ggaatctacc cactgatgaa ctttgcagcc actcgacccc tggggctgcc ccgtgtgctg     1260

gccccacccc cggaggaggt ccaaaaggcc aagaccccga cgccagagcc ctttgactct     1320

gagaccagaa aggtcatcca gatgcagtgc aacctggaga gaagcgagga caaggcgcgc     1380

tggcatctca ctctgcttct ggtgctggaa gaccggctgc accggcagct gacctacgac     1440

ctgctcccaa cggacagcgc ccaggacctc gcctcggagc tcgtgcacta tggcttcctc     1500

cacgaggacg accggatgaa gctggccgcc ttcctggaga gcaccttcct caagtaccgt     1560

gggacccagg cctgacccgg agccccagcc ccaggggacc atgccggggt gctgcctggg     1620

caggccatgt tggggagact ccagcaccgt ggggctgccc tcctccatgc gcctgggagc     1680

acaaaggccc cggtagtgaa ggaacccccc gtctcctgag agtggggctg accctgcctt     1740

gggcgccgag gggttggggg gtgggtgtgg gggagccgtt aggcctccca ggtccttagg     1800

atcagggttg cccccagaac cccttcccat atcctccatt ctccgccctg agttcctacc     1860

caggctgcct ggccggggcc actgcctcct cagcatgcag gaggctgccc tgtagggaac     1920

cccagctctg gggcttgggg gtgagggtca gccctggaca gacctctgcc cagggaactg     1980

ctccatgggg tctgggagag cagccatccc ctgctggcac catagaccca cacaaggagc     2040

ctgcacagca agccagcggt gacacacctg caggtgtcag gcatggcact gggcacaaca     2100

gggacctggc aggagaaaca gaccacagag aggtctggag ttgaggctgt tgtcagcaaa     2160

gcccctggtc ccacacagct ctgccctaga gccacctctt tgacccttta cccaccctga     2220

gaccagaact tgcagcccct ctgcagatct cctctggcca ctgcagcccc tccaatgggc     2280

tttttctctc atgcattccc tggcctggag gcgtcaggga ccccacatcc tccctgctcc     2340

tcagactcac agcccctcca tgttacctcc cgcacctcct ccctggggca gctgctccct     2400

gggcctctga ggatgtcagc tcctggctcc ctgcctctct cccactccac tcctggctca     2460

gtcttagaga tttctatgcc ctcatggatt ctacccctgc cttcctggcc tcttgattct     2520

tggcttgcct ctcctccaat tccaaactta gtgaaatggc cttaagcatt ttaaactgta     2580

tgtatacatt agcgcattca tgcctttcta aacgcatttc aaatgtcaac caggaaggca     2640

caccactgta ttagttttat actgccgctg taaaatttac cacaaactta gtgacttaac     2700

acaaatttat tgcaattctg taggctggaa gtctgactat gggtctcact ggactagaat     2760

caaggctggc aggctgcctt ccttcctgga ggttctaggg gagactctgt ctcctgctcc     2820

ttcaggctgc tggcagaatc cacatccttt cggtggcagg gccaaggtcc ccactttctt     2880

gctgactgta aactaaggcc acttccagct tgtagaggct gcctacattc cttggctctt     2940

ggccccctcc tccatcttca gagctagcag gttcagtctg tgtcacgaac catttctctg     3000

gttccctgca gacaggaaag gttgtcccta aggactcatg agattaggtt gggcccagcc     3060

agataataca tgataatctc cctcctcaag gtttttaata ttaaacacat ctgcaggaca     3120

cattttgcca tgtaaactaa cattcactgg ttccagggat taaggaatga acctcttttg     3180

ttggggaagg gtggcattct gctgaccaca gcactccaac caaaagccaa aaaccaaagc     3240

aagacttact aacgcatatc aaataaatta aaggtacaaa atcgtgaatc tcagttatct     3300

taaatattcc aatactattt acaaaattat tcaaattctc acgccttcca actcaaaatt     3360

agcaatctaa agtaatttcc atatcctaga tggaaaccct catgctaaac tgtctgatta     3420

tgcatggttc taaatggttt cagtggcaaa tacataacat tgtactactg attaaactga     3480

acttaaaagc                                                            3490


<210> 994
<211> 915
<212> DNA
<213> Homo sapiens

<400> 994
gtggtttggg gaaagtgtag gggcaaccaa agatcatcgg cttgactagg ccctttgccc       60

tgaacctcat gaagaaatga taggaggcag acatatgtgc ctaaaaagag cgttgagctc      120

agagaagagc aactcggagt tttgggggtg tgctttgatt tgtgtacatc aatggcagaa      180

tcatccagcg aatcagatca cttccgctgt cgtgaccgat tgagtccatg ggctgccaga      240

tcaacgcaca ggggaactcg aagtcttcct acagtagaag ttaccgagaa ggtcaacact      300

ataacaagta ctttacagga taccagtcgg aacctgcgac aagtggacca gatgcttgga      360

cgataccgag aatacagtaa tggacaggcg ggtgcgatag aacatttaaa agaaagcttg      420

gaacaatcaa tcgaccaact ccggagtcaa cgtttattga gaaactcagg agggagaagt      480

atttctgtta caagtttgag tgcaagtgac cttgatggtg gcactgggtc agagctccat      540

cattttccac ctacctcacc tctcaaggac tatggggatc cacagggtat taaacgaatg      600

agatcaagaa ctggtgtccg gtttgttcaa gagactgatg atatgactca gcttcatggt      660

tttcatcagt ctcttcgaga cctcagcagt gaacaaattc gccttggaga tgatttcaac      720

agggagcttt ccagaaggag ccggtcagat gccgaaacaa aaagggcttt ggaagaattg      780

actgaaaaac ttaatgaagc ccagaaacaa gaagtgtttt ttgtgaagag ccttggaaag      840

gtgaagatac aatgcctgtc ttctgctgaa gtagacaacg tctttccaat taatgtgtgg      900

caatgtggta tctaa                                                       915


<210> 995
<211> 1700
<212> DNA
<213> Homo sapiens

<400> 995
gtagacgcca tgatggatgt gtctggtgtg ggtttcccaa gcaaggttcc ttggaagaag       60

atgtctgcag aggagctgga gaatcagtac tgtcccagcc gatgggttgt ccgactggga      120

gcagaggaag ccttgaggac ctactcacag ataggaattg aagccaccac aagggcccgg      180

gccaccagga agagcctgct gcatgtcccc tatggagacg gcgaagggga gaaagtggac      240

atttacttcc ccgacgagtc gtctgaagcc ttgcctttct tcctgttctt tcacggagga      300

tactggcaga gcggaagtaa ggatgagtct gccttcatgg tccacccgct gacggcacag      360

ggagtggccg tggtaatagt ggcttacggc atcgccccca aaggcaccct ggaccacatg      420

gtagaccagg tgacccgcag cgttgcgttt gtccagaagc ggtatccaag caacaaggga      480

atttacctgt gtggacactc agccggggcc cacctggctg ccatgatgct cctggccgac      540

tggaccaagc atggggtcac gcccaacctc agaggctttt tcctggtgag tggggtcttt      600

gacctggagc ccatcgtgta tacttcacag aacgttgctc tccagctgac cctggaggac      660

gctcagagga atagccccca gctgaaggtg gcccaggcac agccggtgga ccccacctgc      720

cgtgtgctgg tggtcgtggg ccagttcgac tcccccgaat tccaccgaca gtcctgggag      780

ttttaccagg tactcccagt gcagaccctg tgtcaaggag agtggaaagc ctcatttgaa      840

gagctccacg atgtggacca ctttgaaatt gttgagaatc tgacccagaa ggacaacgtg      900

ctcacccaga ttatcttgaa aacaatcttc cagtagttct gacgatactt ggagcctggt      960

ccacgtgcat cccaccttgg gaagcctctc caaagagctt tcggagctga cactgacagc     1020

ttcagtttcc cccagcaccc aggagagcct tgctgtgtct gtctgcccgg caagagtcca     1080

ttctcactgc tgggacactc atgaaaatct ccacgtcctc cctcttccca gcctggatgg     1140

agctccaggg ctggggaacg tccgcaagtc aatgctcaga gatgcccgga gctgcctctt     1200

agactcgtct ggcccatcta cctgctgaca gagcatgaca aagatgacgc tcaaaagtaa     1260

tgccattact tctttttttt tttttttttt tttttttttt gagatggagt cttactctgt     1320

cacccaggct ggagtgcagt ggcgtgatct tggctcactg caacctccac ctcccgggtt     1380

caagcaattc tcctgcctca gcctcctgag cagctgggac tacaggcgcc tgccatcatg     1440

cctggctaat ttttgtattt ttagtagaga cggggtttca acatattggc caggctggtc     1500

tcaaactcct aaccttgtga ttcgcccgcc ttggcctccc aaagtgctgg gattccaggc     1560

gtgagccact gcgcccggcc agaatggcat tatatttaaa tagttcataa agaagcacaa     1620

aagaatatta tttcataaca tgtaaaaatt atataaaacg taaatttcca tgttgataaa     1680

taaagttgta ttggaacacg                                                 1700


<210> 996
<211> 1461
<212> DNA
<213> Homo sapiens

<400> 996
atgtcaggtt ccactccatt tcagatgaga ttagttcatt tagaccttaa aggagctcca       60

ccaaaggtct cgtacctctc agagattttt cctctgttcc gtgcgctagg tgcaaacggc      120

ctcctcattg agtatgaaga catgtttccc tacgagggcc ctctgaggct gctgagggcc      180

aagtacgcct acagcccctc tgaaatcaaa gagatcttgc atctggctgg actcaatgag      240

ctggaggtga ttcccttggt gcagacattt ggacacatgg agtttgtgct gaagcacacg      300

gccttcgccc acctgcggga ggtgggctcc ttcccctgca ccctgaaccc ccacgaggca      360

gagtccctgg cgctggtggg cgccatgatt gaccaggtcc tggagctaca cccaggcgcc      420

cagcggctgc acatcgggtg tgatgaggtc tattacctcg gagaggggga ggcctcgcgc      480

cggtggctac agcaagagca gaacagcacg gggaagttgt gcctgtcaca catgcgggcg      540

gtggccagcg gcgtgaaggc ccggcgcccc agcgtgacac ccctggtgtg ggacgacatg      600

ctccgagacc tgcctgagga ccagctcgca gcgtccgggg tgccgcagct ggtggagccg      660

gtgctctggg actacacggc cgacctggat gtgcacggca aggtcctcct catgcagaag      720

taccggcggt gcggctttcc gcagctgtgg gcagccagtg ccttcaaggg tgccacgggg      780

cccagccagg ccgtgccccc tgttgagcac cacctcagga accacgtgca gtggctgcag      840

gtggcgggca gcgggcccac ggactcactg cagggcatca tcctgaccgg ctggcagagg      900

tacgaccact actctgtgct gtgcgagctg ctgcccgcag gagtcccgtc cctggccgcc      960

tgcctgcagt tgcttctacg cggaggattt gatgaagatg ttaaagcgaa agtggagaac     1020

cttctcggga tttccagcct ggaaaaaacg gaccctgtta gggagggggc cggctccttc     1080

cctggcagca acatccttgc ccttgtcaca caagtcagcc tccatctgcg cagctctgtg     1140

gatgcgctgc tggagggcaa caggtatgtc actggctggt tcagccccta ccaccgccag     1200

cggaagctca tccacccggt catggttcag cacatccagc ccgcagcgct cagcctcctg     1260

gcacagtgga gcaccctcgt gcaggagctg gaggctgccc tgcagctggc tttctacccg     1320

gatgccgtgg aggagtggct ggaggaaaac gtgcacccca gcctgcagcg gctgcaagct     1380

ctgctgcagg acctcagcga ggtgtctgcc cccccgctgc cacccaccag ccctggcagg     1440

gacgttgctc aggacccctg a                                               1461


<210> 997
<211> 733
<212> DNA
<213> Homo sapiens

<400> 997
ctctcctggg gtccagcttg tcgcctctgg ctcacctgtt cctagagcaa tgtcttccca       60

gcagcagcag cggcagcagc agcagtgccc accccagagg gcccagcagc agcaagtgaa      120

gcagccttgt cagccacccc ctgttaaatg tcaagagaca tgtgcaccca aaaccaagga      180

tccatgtgct ccccaggtca agaagcaatg cccaccgaaa ggcaccatca ttccagccca      240

gcagaagtgt ccctcagccc agcaagcctc caagagcaaa cagaagtaag gatggactgg      300

atattaccat catccaccat cctggctacc agatggaacc ttctcttctt ccttctcctc      360

ttccctccag ctcttgagcc taccctcctc tcacatctcc tcctgcccaa gatgtaagga      420

agcattgtaa ggatttcttc ccatcgtacc cttccccaca cataccacct tggcttcttc      480

tatatcccac cccgatgctc tcccaggtgg gtgtgagaga gacctcattc tctgcaggct      540

ccagcgtggc cacagctaag gcccatccat ttcccaaagt gaggaaagtg tctgggcttc      600

ttctggggtt ccaccctgac aagtagggtc acagaggctg gtgcacagtt tctgcctcat      660

tcctctccat gatgccccct gctctgggct tctctcctgt tttccccaat aaatatgtgc      720

ctcatgtaat aaa                                                         733


<210> 998
<211> 3120
<212> DNA
<213> Homo sapiens

<400> 998
gctttttctc ctccgcacag aagtcgcgct cgggcagcct gcgcgctcgc agcaggaacc       60

aggctccagg cgccggcgcc ggggccgggg ccgcggggag gaggcgactt cgctccctgc      120

ggcgggcgcg gcccgggcgc ccgagcctcc tcggccttgg agagcagcgg cggcggcggc      180

accccgggcg cggcaatact gaacactgcg cagcttgcag aggtctcctg gcagccctca      240

ttaggaattc tgtctggccc cgatcagaat actggagacg agaccacgag attgatgagt      300

ttgccttggg agtcggtaag aaggtgaagc caggggcgaa catgggtcag aaggtcactg      360

gagggatcaa gactgtggac atgagggacc ccacgtacag gcccctgaag caggagctcc      420

agggtctgga ttactgcaag cccacccggc tggatctgct actggacatg ccccctgtgt      480

cctatgatgt ccagctgctg cattcatgga acaacaacga ccgatcgctc aatgtctttg      540

tgaaggagga cgacaagctc atctttcacc ggcatccggt ggcccagagc acggacgcta      600

tcaggggcaa agtcgggtat acccgtgggc tgcacgtgtg gcagatcacg tgggccatga      660

gacagcgggg cacacacgcc gtggtggggg tggcgacggc agacgccccc ctgcactctg      720

tcgggtacac aaccctcgtg gggaataacc acgagtcctg gggctgggac ttggggcgca      780

accggctcta ccacgatggc aagaaccagc caagcaaaac atacccagcc tttctggaac      840

cagatgagac attcattgtc cctgactcct tcctggtagc cctggacatg gacgacggga      900

ctctgagctt cattgtggat ggacagtaca tgggagtggc ttttcgggga ctcaagggca      960

aaaaactgta tcctgtagtg agtgccgtct ggggccactg tgagatccga atgcgctact     1020

tgaacggact cgatcccgag ccgctgccgc tcatggattt gtgccgtcgc tcggtgcgcc     1080

tggccctggg gagggagcgc ctgggggaga tccacacgct gccgctgccg gcttccctca     1140

aggcctacct cctctaccag tgacgttcgc catcataccg ccagcgcgac agccacctgg     1200

tgccaactca ctgagccgcc tgccgctggg gccgccgcac cctgcacctt ggaccggcat     1260

ccgtagccat ggacagaggt ccctggtctt ccctcatcct ccgtggctgc ctccatggga     1320

caaggaccga ttccaacaca ggctcctctt tcccccttcc cgacatcagc agaaggcagc     1380

atccctgcat gccgtccgta tacaacccct ctttgaaaaa agacacagag aataaactcc     1440

tacgaaagcc ctacattgag ctccaatctg ctcggggtgg gacgggtgct tcccacacct     1500

ctgggagaag gctgcagcca cctgggggtc ccagggtggt gggggtggca ggtggtacca     1560

cagctctgag agcagatacc aggggtacta agaggtgctt agacaagggc tggtgcccgg     1620

cccagggtgc ccagcggggc catgccatgg cagataaagc tcaggacgtc aaaaactcac     1680

catggacccc aaggcagaaa ccaagaactg tctgcaggca aataagcacc cagcacccat     1740

cctggctgcc ggtgccccgt accctgtatt tattctttta acaataacaa aagccattta     1800

tttattccat ctagaaagga aaccctgttt cagtcccctc tctctggctg ttctgttact     1860

ttccttccac ctgtgccctc cctgggatat gtatgcctcg cccgccctcc ctgggcacat     1920

gtgcacacgt gcccaggcac aagtatgtct ctgggtccct tgccctgcag tttccagggg     1980

gctctgctcc aagttcccta gcgggcccct cagggagaaa tagcctcacg tgcaatctgg     2040

gtgtcttcgg gggcccgtct ggaagggctg cagcaattcc cctgtgtctc caggtaacca     2100

gctaactctt gggctcaggc acccttgcac agggttgcat ttctttagtc ttctgtgggt     2160

cttttgatgt gggtttgatt ttgcttttgc ttttctagct gagatttccc aagtgcatcc     2220

tcagaagctc tgggtgtgcc agaggacccc cagaactaag aagggagggc gagtgggtct     2280

ccattccccg agaagccggg ggcagggtgg gatggggaag accaggagca gagtcgagcc     2340

tcacagaagc cagcgcgggt ctctgctcag caccccagcc ggggctctgg acccagggta     2400

acagccccag ttcatcccaa cccctctcag agcctcaaga ggggtagctc ggctgccgga     2460

agagaggggt gccctatccc tggcaacccc tccacgtagc gtaccccagc acctgccacc     2520

gcctttgcca tttctttgag cttgaagtta actctcttag agtctaactt tggttcattt     2580

ctgcacaggt acaatagatg actttatttg tttaaaatgt ttaatatata tacatacata     2640

tatatatatt tgtctgtaag aattatgttt taaacagctg ctgtagagta ccttttttta     2700

agtaaatctt acagtggagt atatttttta aagcacaaaa ttggtgccaa gactgggtga     2760

gaaatgtaca ttaccccctt attattttga cggttttttt tttcggggca ggggacctta     2820

cctgtaagac ttttaaagat tttcctccct cctgtttcag gtgggtcaca ttctgatgaa     2880

tgtttccctt gtacagatcc cagcttatgg ccttgaccca gccgtcctca cagatgccgg     2940

gtgaccctct agctctctct gcatctccca ccccccgaca ccctgggacc ctcgacccca     3000

cccttctttc ctaccagccc agagccttgt ggcttgtaca gttttgaaac tcccgttcta     3060

ttttatgatg gttgataata gtcagtaacc taataaagga acgtttgtta aaatatcaaa     3120


<210> 999
<211> 3859
<212> DNA
<213> Homo sapiens

<400> 999
cggacggggc cgccccgatg ggacgccgcg ctccggcccc tgcgcgccgc tgagccgagc       60

gccccccgct gccgagaccc ccgccgccac cgccagccgc tgccccctcg cccccgcccg      120

ggccgggagc ctcgtccccg tcccccggaa agctggattt ccgaggctgg aggcgcctgg      180

ccggctgggt ggggaccacc atgggcaacg cggccggcag cgccgagcag cccgcgggcc      240

ccgccgcgcc gccccccaag cagcccgcgc ctcccaagca gccgatgccc gcggccggag      300

agctggagga gaggttcaac cgcgccctga actgcatgaa cttgccccca gacaaggtcc      360

agctgctgag ccagtatgac aacgagaaga agtgggagct catctgtgat caggagcggt      420

ttcaagtcaa gaatcccccc gcagcctaca tccagaagct gaagagctat gtggatactg      480

gtggggtcag ccgaaaggta gcagctgatt ggatgtccaa cctggggttt aagaggcgag      540

ttcaggagtc cacgcaggtg ctacgggagc tggagacctc cctgaggacc aaccacattg      600

ggtgggtgca ggagttcctc aatgaagaga accgtggcct ggatgtgctg ctcgagtacc      660

tggcctttgc ccagtgctct gtcacgtatg acatggagag cacagacaac ggggcttcca      720

actcagagaa aaacaagccc ctggagcagt ctgtggaaga cctcagcaag ggtccaccct      780

cctccgtgcc caaaagccgc cacctgacca tcaagctgac cccagcccac agcaggaagg      840

ccctgcggaa ttcccgcatc gtcagccaga aggacgacgt ccacgtctgt attatgtgcc      900

tacgcgccat catgaactac cagtctggct tcagccttgt catgaaccac ccagcctgtg      960

tcaatgagat tgctctgagc ctcaacaaca agaaccccag aaccaaggct ctggtgctgg     1020

agctgctggc ggccgtgtgc ttggtgcggg gaggacatga catcatcctt gcagcctttg     1080

acaacttcaa ggaggtgtgt ggggagcagc accgctttga aaagctgatg gaatatttcc     1140

ggaatgagga cagcaacatc gacttcatgg tggcctgcat gcagttcatc aacattgtgg     1200

tacattcggt ggagaacatg aacttccgtg tcttcctgca atatgagttc acccacttgg     1260

gcctggacct gtacttggag aggcttcggc tcaccgagag tgacaagctg caggtgcaga     1320

tccaggcgta cctggacaat atttttgatg tgggggcgct gctggaggac acagagacca     1380

agaacgctgt gctggagcac atggaggaac tgcaggagca agtggcgctg ctgacagagc     1440

ggcttcggga cgcggagaac gaatccatgg ccaagattgc agaactggaa aaacagctaa     1500

gccaggcgcg caaggagttg gagaccctgc gggagcgctt cagcgaatcg accgccatgg     1560

ggccctccag gcgtccccca gagcctgaga aagcgcctcc cgctgccccg acgcggccct     1620

cggccctgga gctgaaggtg gaggagctgg aggagaaggg gttaatccgt attctgcggg     1680

ggccggggga tgctgtctcc atcgagatcc tccccgtcgc tgtggcaact ccgagcggcg     1740

gtgatgctcc gactccgggg gtgccgaccg gctcccccag cccagatctc gcacctgcag     1800

cagagccggc tcccggagca gcgccaccgc cgccgccccc actgcccggc ctcccctccc     1860

cgcaggaagc cccgccctct gcgcccccac aggccccgcc tctccctggc agcccggagc     1920

ccccgcctgc gccgccgctg cccggagacc tgccgccccc acccccgcca ccgccaccac     1980

ctccgggcac tgacgggccg gtgcctccgc cgccgccgcc gccgccgccg cctcccggag     2040

gtcctcctga tgccctagga agacgcgact cagaattggg cccaggagtg aaggccaaga     2100

agcccatcca gactaagttc cgaatgccac tcttgaactg ggtggcactg aaacccagcc     2160

agatcaccgg cactgtcttc acagagctca atgatgagaa ggtgctgcag gagctagaca     2220

tgagtgattt tgaggaacag ttcaagacca agtcccaagg ccccagcctg gacctcagcg     2280

ctctcaagag taaggcagcc cagaaggccc ccagcaaggc gacactcatt gaggccaacc     2340

gggccaagaa cttggccatc accctgcgga agggcaacct gggggccgag cgcatctgcc     2400

aagccattga ggcgtacgac ctgcaggctc tgggcctgga cttcctggag ctgctgatgc     2460

gcttcctgcc cacagagtat gagcgcagcc tcatcacccg ctttgagcgg gagcagcggc     2520

caatggagga gctgtcagag gaggaccgct tcatgctatg cttcagccgc atcccgcgcc     2580

tgccggagcg catgaccaca ctcaccttcc tgggcaactt cccggacaca gcccagctgc     2640

tcatgccgca actgaatgcc atcattgcag cctcaatgtc catcaagtcc tctgacaaac     2700

tccgccagat cctggagatt gtcctggcct ttggcaacta catgaacagt agcaagcgtg     2760

gggcagccta tggcttccgg ctccagagcc tggatgcgct gttggagatg aagtcgactg     2820

atcgcaagca gacgctgctg cactacctgg tgaaggtcat tgctgagaag tacccgcaac     2880

tcacaggctt ccacagcgac ctgcacttcc tggacaaggc gggctcagtg tccctggaca     2940

gtgtcctggc ggacgtgcgc tccctgcagc gaggcctaga gttgacacag agagagtttg     3000

tgcggcagga tgactgcatg gtgctcaagg agttcctgag ggccaactcg cccaccatgg     3060

acaagctgct ggcagacagc aagacggctc aggaggcctt tgagtctgtg gtggagtact     3120

tcggagagaa ccccaagacc acatccccag gcctgttctt ctccctcttt agccgcttca     3180

ttaaggccta caagaaagct gagcaggagg tggaacagtg gaaaaaagaa gccgctgccc     3240

aggaggcagg cgctgatacc ccgggcaaag gggagccccc agcacccaag tcaccgccaa     3300

aggcccggcg gccacagatg gacctcatct ctgagctgaa acggaggcag cagaaggagc     3360

cactcattta tgagagcgac cgtgatgggg ccattgaaga catcatcaca gatctgcgga     3420

accagcccta catccgcgca gacacaggcc gccgcagtgc ccgtcggcgt cccccgggcc     3480

ccccactgca ggtcacctcc gacctctcgc tgtagccgct atttctgcag gtggattctg     3540

caggggtgtg gggccgtgga caggctgagg ctcaaggaag gtggtcctca gctcggctgg     3600

ccgggcagcc cctcctccgc tgtggcccgc ctcaaacggg ctggtgcatc ctcctcttgg     3660

ccacagaggg cagcatcgcc cgccccttcc cccaaatgct gcttgcagca cccaccctaa     3720

agccccctcc aaatagccat acttagcctc agcaggagcc tggcctgtaa cttataaagt     3780

gcacctcgcc cccgcaagcc ccagccccga ggaccgtcca tggaccttat ttttatatga     3840

gattaataaa gatgtttgc                                                  3859


<210> 1000
<211> 743
<212> DNA
<213> Homo sapiens

<400> 1000
gggtccgttg gggcagaacc atggaggaaa agccttcgaa agtgtcgctc aagtcttccg       60

accgccaagg ctcggacgag gagagcgtgc atagcgacac tcgggacctg tggaccacga      120

ccacgctgtc ccaggcacag ctgaacatgc cgctgtccga ggtctgcgag ggcttcgacg      180

aggagggccg caacattagc aagacccgcg ggtggcacag cccggggcgg ggctcgttgg      240

acgaggggta caaggccagc cacaagccgg aggaactgga cgagcacgcg ctggtggagc      300

tggagttgca ccgcggcagc tccatggaaa tcaatctggg ggagaaggac actgcatccc      360

agatcgaggc cgaaaagtct tcctcaatgt catcactcaa tattgcgaag cacatgcccc      420

atcgagccta ctgggcagag cagcagagca ggctgccact gcccctgatg gaactcatgg      480

agaatgaagc tctggaaatc ctcaccaaag ccctccggag ctaccagtta gggatcggca      540

gggaccactt cctgactaag gagctgcagc gatacatcga agggctcaag aagcgccgga      600

gcaagaggct gtacgtgaat taaaaacgcc accttgggct cgagcagcga cccgaaccag      660

ccccgtgcca gcccggtccc cagacccaag cctgacccca tccgagtgga atttgagtcc      720

taaagaaata aaagagtcga tgc                                              743


<210> 1001
<211> 5157
<212> DNA
<213> Homo sapiens

<400> 1001
gcatcatgga atgatataaa aatgcagctt tccaatcaca ctaagggtct ctctatttct       60

tctcttgacc accaatcagg aacctttgct ggaagcttgt ttctgattgg tgaaagtaag      120

ccataacagt ggaatgccaa ggagtaaata caaaagtgta gcaacaactg agtttgctgt      180

ctcactaccc tcagcctagg ccaacctgga ctccttcacc ccaaatgagg tgaccgctac      240

attttatatg aagacactga tttaccattc aactgtgatc catcttataa catggcaatc      300

caatacagac aggaagataa aactcaacaa cagctaaaat aaagtgtatt cccaggtaaa      360

atagacaagt gctttaattt gaaatggatt cgtccgatga gtgtcagtta caagggcaga      420

gaaggtacca gtgcagaaga gctctgactg tgggcagtgt caccaggtcc cactaagtgg      480

caacacttgt gctgggtgac ttgacccatc ttgatgtata aacccatagc cagacaggac      540

gtgcaaacag gtctcatggt gaatgcgatg ctgtggaaaa tgacatggag aatggctgtc      600

tctcagctag ggaggagggt cttggtgtcc tagtaaagaa tgttcacgtc ctggagttgg      660

tggttggtgt tctatctagg cgatgagaga aggatgcttt tcctaatgag cacctggtgg      720

gaatagagtc tctctttgca cttcgctgga ggaagaaatt tctaccactt attttttctt      780

cttgcttata gaatacacat tgcagaaaaa ggatgaagtt gaccagtgaa aagttgccca      840

agaacccctt ttatgcctct gtatctcagt atgctgctaa aaaccaaaaa tttttccagt      900

ggaaaaagga aaagactgat tacacccatg ctaatttggt ggataaggca ttgcagctct      960

tgaaggaaag aatactgaaa ggagacactc tggcatattt cctacgaggt caactatatt     1020

ttgaagaggg atggtatgaa gaagcattag aacagtttga agaaatcaag gagaaagacc     1080

atcaagcaac ttaccagcta ggagtgatgt actatgatgg gctggggacc actctagacg     1140

ctgagaaagg ggtggactat atgaagaaaa ttcttgattc tccatgtccc aaagcaagac     1200

acttaaaatt tgcagctgct tacaacctcg gaagagctta ttatgaagga aaaggtgtta     1260

aacgatcaaa tgaggaagct gaaagactgt ggcttatcgc agcagacaat ggaaatccca     1320

aagctagtgt gaaggctcaa agtatgctcg ggctgtatta ctcaaccaag gagcccaagg     1380

agttagaaaa ggcattttac tggcattccg aagcatgtgg caatgggaat ctggagtccc     1440

agggtgcact tgggctcatg tacttgtatg gacaaggcat ccggcaggat acggaagctg     1500

ccctgcagtg cttaagagaa gcagcagaac gcggaaacgt ctatgctcaa gggaatctcg     1560

tggagtatta ctataagatg aaatttttta caaagtgtgt tgcattttcc aaaaggatcg     1620

ctgactatga tgaggttcac gacatcccca tgatcgccca ggtcacagac tgtctcccgg     1680

agttcatcgg cagaggcatg gcaatggcat ccttctacca cgcaaggtgt cttcagcttg     1740

gcttgggcat caccagggat gaaacaaccg ctaaacacta ttattctaaa gcttgtcgtc     1800

tgaatcccgc attggcagat gaacttcact ccttacttat tcgtcaaaga atttagacca     1860

caatgtattt caacaaagat catcaatgct aacacctcac aatgtgtgta tttttacagt     1920

agctatgttt ggttattttg cacatcacaa attacactat cctgggtatt ttacaggtga     1980

catgttactt cgttcttgaa ttcgtacgct gttaagtttt gcaacttgaa acctagacac     2040

aaggtcaaat tgctggaaga gtcctcagag gtccacctct taccctacag actggccgag     2100

accatatcaa gtattaaaac cattctatac agcaagtatc gtttatcctt tcttaaacac     2160

cgagtctcca aaaatactta gtttagcttt agtttagtaa gttcagaagt agaaacaaac     2220

ttatttaaaa ccatcatttg aaagtttaat tctttaaatt tgtctcttag ttttgtgaat     2280

tttgaataat aatgtttaaa ttttgtttca gtcatttaaa atttaaattt tcagtcattt     2340

aaaattttaa aaatttaaaa tttcacaaaa ctaagggtaa aagacattta aagaattaaa     2400

cttaaataag tgtgtgcagc atttctactt ctgaagttat taaagctaaa actgcactaa     2460

gccttttgag acatccttta ttcttaaaaa gctcataaat aattggctta ttacatataa     2520

acttcaaaaa agtgggttat aagacattgc tttagaatct tgcccctcca aatcttccct     2580

caaagatctt aatgagtaaa acaactgcta catacatatg cagaatgtgt aataaaacaa     2640

aaagcaattg ctatatgaaa atattcgtaa gaaaagtaaa gcaaattgtt tctttgtgct     2700

tcagctcatt ttccatattt ttaaaaccct gtggtaaaag cctcaatgaa atcatttaca     2760

agaactacaa ttaaatattg ttaaaattag caaaaggctt tccgtatata gatgacatct     2820

atgaaggcaa aaggtgacag taaaaacagt aagatccata tgcataagat tgtacaaggc     2880

tattcatttg tgaaacaaat atacatatcg aagacaggtc tcagagatac cttaactatt     2940

ccttttttta taaacatatt aaaggatgtg gctttatttt ataaatcaca accatcccaa     3000

cagtggattt aaacaagatt tctttttagt aatgggaaaa tgcaattaat atggaggtga     3060

tagtcactaa gaactgttga atggcagaaa agtatttgct ctcgttttat gttctggctt     3120

gtctgtattg cctgaacttc attttgtctt tgtgtaaggg aagaaatttc aacagactcg     3180

ggtttgagat atcctcaaat ggtcatgtat ttctgtctca aatctcttaa taccacccat     3240

gtaacattcc ttcaaccact tgaagatcca aattcccaac tagtattctc ttctccacac     3300

ttaatccagt tcctaaagat tattattatt attattatta ttattttttt ttttttgaga     3360

cggagtctcc tgacctaatc ttagcccggc gcagtggctc acgtctgtaa tcccagcact     3420

ttgggaggct gaggcgggca gatcatgagg tcaggagttt gagaccaggc tggccaacgt     3480

ggtgaaaccc cgtctctact aaaaatacaa aaattagccg ggcgtgatgg cggacgcctg     3540

tagtcccagc tactcgggag gctgagacag aagaactgct tgaaaccagg aggcagaggt     3600

tgcagtgagc tgagatcgcg caaattgcac tccagcctcg gtgacaagag cgagactcca     3660

tctcaaaaaa aaataaaaag aatcttaaaa taggaacata ataaaagatc ggccctaagt     3720

aaagagcact ttttaaactg ccattaaaga tgggtttcag aaatcataaa ctttgacgtg     3780

tgccatacat ggtaacatgc tatgcttata tgtcttctat aaatccaatg cagaatttaa     3840

aatttcagtt tactctagtt accataaagc taatgctctg gcacaagcga gtccctgcaa     3900

actaccactg ctgaggacag tagtaaaccc cttgacctga gactgcggtg agtctgtaac     3960

tcgagtgcat tgagacttcc agatcattac tcttacacac acacacacac acacacatac     4020

acacacacac actccttctc taagattcct tgtagctgat atctcatgga aaaatgacat     4080

tttatcataa ataaatatag agacaaaata atagtgatct ttctcattcg caatgtaaac     4140

ttaacagcta cagtttaaat gatagcatag aattatgcct aaaatagaca tttcccataa     4200

ttgtattgtg ataagttctt caggcttgac aacttcacat tgcctctctt ccttgaatgt     4260

attttatctg gtcttttcta tatagtcttt tgaaggataa tttttatcaa tagccaactt     4320

tgggtatttt tttaagtgtc aaatatcatc atggtttgaa aaaaggataa aaaagctata     4380

actaaaaaaa tcttaaggat aacatttggt ttactaattt ttaatcattt atctttcaga     4440

acttgtttct tatcaagaag ttagcaggta tgatatgtat atcatacgta tataaactgg     4500

cataggttac atcctagggc atgaggggag tatctttcag ggattcaaat ggaattttta     4560

cctgttactt gtttaattgt tttgttttca atattcttgg ggattagaca ggggaaggta     4620

ttttattact gcataataga tggtgaaacc caggaaaatt aagtacttgt gcatggcccc     4680

actatcaata acacaaagtc tgtactctgg atctccccta atgtccctgt ggtctaaacg     4740

gcttgataat acaaccgagc ccctgaagta gctgccctcc tctttccgct cccccatctc     4800

ggccctgccc atactccaag ggtcagctcc catctctcct ccctaatgcc tcacttcaag     4860

cactaatttg gctctttctg ctcactaaaa atcatatatt ttacagattt attttgtttc     4920

tggagaaggc agcaaacttt tacttccctg cagaagtagt taagtacata gtgttttctc     4980

taaaaaggca tttgataaat atttgaacag cctgtagagt ttcaacctct ttgagatata     5040

agtatcttaa atatcataga gcactgtgat tcatttttat attttattgc tttgaatgct     5100

caaactatgg gaaatctttg gtaaaaataa agacaataaa atcttcacaa taacttt        5157


<210> 1002
<211> 6089
<212> DNA
<213> Homo sapiens

<400> 1002
cagcgctggc gtcaatgctc ccttcctcgg gccattggag actccgttgc tttttaatgg       60

cggcagcggc tgctgggtga gcagctggag gccggacagt gttcgtccca tccggagagg      120

atcgctttct cctggcgtca ccagcgctgg gttggtgggg gtagcttttc cctctttgct      180

cctccattct tgaagaaaga agaagatgcc actgccattt gggttgaaac tgaaacgcac      240

ccggcgctac acggtgtcca gcaagagttg cctggttgcc cggatccaac tgcttaataa      300

cgagtttgtg gagttcaccc tgtccgtgga gagcactggc caggaaagcc tcgaggccgt      360

ggcccagagg ctggagctgc gggaggtcac ttacttcagc ctctggtact acaacaagca      420

aaatcagcgc cggtgggtag atttggaaaa acctttgaag aagcagctgg ataaatatgc      480

attggaacct accgtctatt ttggagtggt gttttatgtg ccttcagttt ctcagctgca      540

gcaggagatt accaggtatc agtattatct gcaactgaag aaagatatct tggaaggaag      600

tattccttgt accttagaac aagcaattca gctagcaggc ttagctgttc aagcggattt      660

tggtgacttt gatcagtatg aatcccagga ctttcttcag aaatttgcct tgtttcctgt      720

gggatggtta caagatgaaa aagtattgga agaagcaacc caaaaagtgg ccttactaca      780

tcagaaatac agagggctca cagctcctga tgctgaaatg ctgtacatgc aggaggtaga      840

gagaatggat ggctatggag aagagagcta ccctgctaag gatagccaag gaagtgacat      900

atccattgga gcgtgtcttg aaggtatctt tgtgaaacac aagaatggaa ggcatcctgt      960

ggtatttagg tggcatgaca ttgccaacat gtcccacaac aagtcctttt ttgcattaga     1020

gctggcaaat aaagaggaga ccattcaatt tcaaactgaa gacatggaaa cagcaaaata     1080

catttggaga ctctgtgttg cgcgacacaa gttttacaga ctaaaccagt gtaacctgca     1140

aactcagact gtcacagtga acccaatcag gaggaggtct tcttcaagga tgtctctgcc     1200

taaaccccag ccctacgtga tgcctccccc accgcagttg cactataatg gacattatac     1260

agaaccatat gcttcttccc aagataacct ctttgtgccc aaccagaacg gatactactg     1320

tcactctcag acaagcttgg atagagccca gattgacctc aacggtcgga tccgtaatgg     1380

cagtgtctac agtgcacaca gcaccaactc cttaaataat cctcagccct acttgcagcc     1440

ctcgccgatg tcgtccaacc ctagcatcac cgggagtgac gtcatgaggc ctgactacct     1500

cccgtcccat cggcacagcg ccgtgatacc cccgtcctac cgccccaccc cagactatga     1560

gactgtgatg aagcagctca acaggggcct ggtgcatgcg gaacggcaga gccactcgct     1620

gcgaaacctc aacatcggca gctcgtacgc ctacagcagg cccgcggcgc tggtctacag     1680

ccagcccgag atccgcgagc acgcacagct cccctcgcca gcggccgcac actgcccgtt     1740

cagcctgagc tacagcttcc acagcccgtc tccctacccc taccctgccg agcggcggcc     1800

cgtggtgggc gcggtcagcg tgccggagct gaccaatgcg cagctgcagg cgcaggacta     1860

cccgtctccc aacatcatgc ggacgcaggt gtaccggcca cccccaccct acccgccccc     1920

caggcccgcc aacagcacgc cagacctgtc ccgccacctt tacatcagca gcagcaaccc     1980

cgacctcatc acgcggcgcg tgcaccactc ggtgcaaacg ttccaggagg acagcctgcc     2040

cgtggcgcac tcgctgcagg aggtcagcga gcccctcacc gccgcgcgcc acgcgcagct     2100

gcacaaacgg aacagcatcg aggtggccgg gctcagccac ggcctggagg gcctgcggct     2160

caaggagcgc accctatccg cgtcggcggc agaggtggcg ccgcgagccg tctcggtggg     2220

ctcccagccc agcgttttca ccgagaggac acagcgagaa gggccggagg aggcggaggg     2280

cttgaggtac ggccataaga agtccctgtc ggacgccacc atgctaatcc acagcagcga     2340

ggaggaggag gacgaggact tcgaggagga gagcggggcc cgggcgcctc ctgcacgtgc     2400

gcgcgagcct cggcccggcc tggcccagga cccacctggc tgccctcgcg tcctgctcgc     2460

cgggcccctg cacatcctgg agcccaaggc ccacgtccca gacgcggaga agaggatgat     2520

ggacagcagc cccgtccgca cgaccgcaga ggcccagcgg ccctggagag acgggctgct     2580

gatgccctcc atgtcggagt ccgacctcac cacgtcaggc cgctaccgag cccggaggga     2640

ctctctgaag aaaaggccgg tgtcggacct tctctctggg aagaagaaca tcgtggaagg     2700

gctcccgcct ctagggggaa tgaaaaagac tcgagtagat gcaaaaaaaa ttggtcctct     2760

taaactggct gccctaaatg gactctccct atctcgagtg cctctgcctg atgaaggaaa     2820

ggaagtggct accagagcaa cgaatgatga aaggtgtaaa attctggaac aacgattaga     2880

acaaggaatg gtattcacag aatatgaaag aattcttaag aaacggctag ttgatgggga     2940

gtgctcaaca gcacgactcc ctgaaaatgc agaaagaaat cgattccaag atgttcttcc     3000

ttatgatgat gtgagagtgg agttggtccc aactaaagaa aacaacactg gttacatcaa     3060

cgcatcacat attaaggtct ctgtcagtgg aatcgaatgg gattatattg ccacacaggg     3120

accattacag aatacctgtc aagatttttg gcagatggta tgggaacagg gaattgcaat     3180

tatagcaatg gtgacagcag aagaggaggg tggaagggag aagagcttta ggtactggcc     3240

acgacttggt tccaggcaca acactgtcac ctatggaagg tttaagatca cgacccggtt     3300

ccgcacagac tctggctgct atgccaccac aggcctgaag atgaagcacc tccttactgg     3360

gcaagagagg accgtctggc acctccaata cacagactgg cctgaacatg gctgtccaga     3420

agacctcaag ggatttttat catatcttga agagatccag tctgttcgac gccatacaaa     3480

tagcacaagt gatccccaaa gccccaaccc tccgttgttg gtccactgca gtgctggggt     3540

aggaaggact ggcgtggtga ttttgtcgga gatcatgatc gcctgcctgg aacacaatga     3600

ggtgctggac atcccgagag tgctggacat gctgaggcaa cagagaatga tgctggtgca     3660

gactctctgc cagtacacat ttgtgtacag agtcctcatc cagttcctga aaagctccag     3720

gctcatctaa gctcccacaa tttcttacgg ggccagtcat gtgaagcgtt tacagcttaa     3780

aaaaaaagcg cttgcctaac tcatactttc ccgttgacac ttgatccacg cagcgtggca     3840

ctgggacgta agtggcgcag tctgaatggc ggcacgctga aggaaacgtg cgaagcacag     3900

gctgaagagg ggtttctaac ctgggaaagg tgctcaagga ggacttggtt tcaagggcct     3960

tgccctgccc cggtctgtcc ggtttgcagt acttgcacac attttggaga ttgtattttc     4020

tagacaattc tctattttac tgaagctatg ctgggcaatt ctggcaatca ttaaagtgca     4080

tagatttcta tcttaaacta atttttgata atggagtttt tattttatga caaatattta     4140

gggatttttc tagtgagaaa caactttgtg taaggatgat ccacagatat gagttgctcc     4200

tatataactt tgtatttaaa aatcatgtta ttatcttttg ttatttttta aaaaccttgg     4260

gtacttaata atggtttagt tgccaaactg aaaactatac tgagaatctg tgttattttg     4320

aaacatcaaa aggatttttc tatccagaac attttttatc ctaaaaattc tatatagttg     4380

taccttctgt ttttcaaatg agagctcaat tcatttagat actgaaatga gtcagttaat     4440

gtaaagttga ggatgaaggc acattattta aaatgtaaga gaataagcat tattttttca     4500

gtattattca tagatctaaa tgaatttgat tttattggtt gaaaatgaag tgaaaaacaa     4560

ttgcctaggg tggttttaag cacttttttg ttaaaaacaa atctgagttt taatatatgt     4620

gttgctttgt agatgacaca ataacaatgg gcgctgagaa gcgttttggg agagattaag     4680

gactaagagt atgtaagatg actaggacaa gagtaggtgg agtgtgatgg taaatgcagg     4740

atgccttcgt ctttacaaaa atgcagtatt atctatactc agactgaggt gctgggatgg     4800

cgagcagggg accccacagc actgtcccca gggaattcaa gtcctgtgac cgccagtgac     4860

ttactccgtt tccttggggc ttttcccacc tcaacctgta ttgtttcttt ttcataaata     4920

aattcagcat tatagtatca ttaaaagaag ccttaaagag gcgtattttt ccttttggtt     4980

gaaggaaggg aatagttaat aatagttttc acctcttctc ccaaaaagta cagtccaaat     5040

ttgtgcacag agattgctgt ggtattcaag aggtacttgc attttagctc cttaataatt     5100

ccctggccag tgttagctgt ttagtgcccc ctcacccatc ccatttaggc acatcccaat     5160

agacagagcc aggctgagtt acagggggag agtgtcatct ctggccccga ttaagatggc     5220

cttgtcacag tgaccgctga gtaggcatgg atgagtggga tatttagctg aggaaccctt     5280

tcccttttcc ttctttttgg ggtctcttct tacagtgaac ttccaaaatg tcaaatctag     5340

ggctgtttcc caaattacac tattctaggc atcattttga ttcccatgtc actccttaac     5400

tcacttcctt gagcactaca tgtatgttgt cagccacgag acaggacttc ctaaatagtg     5460

tgtgcaccag cctaactctg ccttacccag aaaccaacca cctaagagga aaactcagaa     5520

gatattaatg aaaactaatt gaaagtacgc acacttctca tgtaggaaca aaattaaaat     5580

tttacatttt tattttacaa aattaaaaaa ttacattttg taggaacaaa atgtaaattt     5640

tgtaaataca aaattctttt taaagtcctg tttaaagaac agtagaacta agtgaaaata     5700

ttcagaacga gctccttaga agaaaggaat aagaactttt tactggaact attttccatc     5760

tctagaaaaa gtgcttcttc ccctccccct ccctctccat ggtacgtttt tgtgaaaatg     5820

cttttctgtc aggtttaaac aaacagtttg acatagctcg ttgacaagaa catattgtaa     5880

aacaaatcta attaaagagt aatatgtggt ctatttgtgt tcctgttgta ataatttgat     5940

aagtaaactt ctgagggcaa aattactgtt taatattact cttaaaatgt tgcatgtttg     6000

gcgtcattcc taagagccat gtaattttaa acttttaatt gcagttagtg aatatgaaag     6060

gatttctgaa taaaaatcta tccacatta                                       6089


<210> 1003
<211> 2815
<212> DNA
<213> Homo sapiens

<400> 1003
cacgccggcg ctccaggcgc ggcaggctgc cgcccccgga agtagtgggt accgggacgc       60

cgtgaggcgg aagctgtgta tggcgggagg ctgtggcggt cccttggtgg ggaagctgtt      120

gctgttgcta gacgacggga actagctctc gtcacttcct cagcccgccg tctgcccact      180

cctctagccg gaacctgggg gcccggagcc ggggtaggca cagagttgtc ctcggaggtc      240

caggacagcg gccagcccgg cggcgggagt cagggccacg ccacctgcag ggaagaaccc      300

gagtcgaagc gggaagatgg ctgcagacaa gcctgcagat cagggagcag agaaacatga      360

aggcacaggt cagtcctctg ggatcactga tcaagagaag gagttatcca ccaatgcttt      420

ccaagctttc acatctggaa attatgatgc ctgtctacaa caccttgcct gtctacaaga      480

tataaacaaa gatgattata aaataatttt gaatacagca gtagctgagt tttttaaaag      540

taaccaaaca acaacagata atttgagaca aacacttaac cagctgaaga atcaggtcca      600

ctcagctgtt gaagaaatgg atggattaga tgatgttgaa aacagcatgt tgtactataa      660

tcaagcagtc attctttatc atctgcggca gtatacagaa gccatatcag ttggtgaaaa      720

actttatcag ttcatagagc cttttgaaga aaaatttgcc caagcagtgt gttttttgct      780

tgtagacctg tatatattaa cctaccaagc tgagaaagct ttgcatcttc ttgctgtcct      840

agaaaaaatg atttcacagg gtaacaataa caaaaatgga aagaatgaga ctggtaataa      900

caacaacaaa gatggatcta atcataaagc tgaaagtgga gctctaatag aagctgcaaa      960

atcaaagata catcagtaca aagtacgagc ttatatccaa atgaagtctc tgaaagcatg     1020

taaaagggaa atcaagtcag tcatgaatac agctggaaat tccgcaccct ctctctttct     1080

taaaagcaat tttgagtact taagaggtaa ttatcgaaaa gccgtgaagc tattaaatag     1140

ttcaaacatt gctgagcatc caggattcat gaaaacaggt gaatgcttga gatgcatgtt     1200

ctggaataac cttggttgca tccattttgc catgagcaag cacaatttgg gaatattcta     1260

ctttaaaaag gctctgcaag agaatgacaa tgtctgtgca cagctcagtg caggtagcac     1320

tgatccaggt aaaaaatttt caggaagacc catgtgtacg ttactaacca ataagagata     1380

tgagttgctg tataactgtg gaattcagct tcttcacatt ggaaggcctc ttgctgcctt     1440

cgaatgtctg attgaagctg ttcaggttta tcatgcaaat cctcgcctct ggctacggct     1500

ggctgaatgc tgcattgctg ccaataaggg gacttctgaa caagaaacta aaggccttcc     1560

cagcaaaaaa ggaattgtac agtctattgt tggtcaaggc tatcatcgta aaatagtttt     1620

ggcatcacag tctatacaga atactgttta taatgatggg cagtcttcgg ccattcctgt     1680

agccagtatg gagtttgcag ccatatgtct cagaaatgcc ttgttgctgc tacctgaaga     1740

acagcaagat ccaaagcagg aaaatggggc taaaaatagt aatcaattag gtgggaacac     1800

agagagcagc gaaagcagtg aaacttgcag cagtaaaagc catgatggag ataaattcat     1860

tccagctcca ccttcttctc cattgagaaa acaggaatta gaaaacttaa agtgctccat     1920

acttgcttgc agtgcctacg tggctctggc tttgggtgat aacctcatgg ctttgaatca     1980

tgcagataaa cttcttcagc agcccaagct gtcaggatct cttaagtttt tgggacattt     2040

atatgctgca gaagccctca tctctctcga cagaatatct gatgccatta ctcacttgaa     2100

cccggagaat gtcactgatg tctccttagg gatctcttca aatgagcagg accaaggatc     2160

agacaaaggt gaaaatgaag caatggaatc ctctggtaag cgggcccctc agtgctaccc     2220

cagttccgtc aactctgcca ggactgtgat gctgttcaac cttggcagcg cttactgcct     2280

gaggagcgaa tatgacaaag cccgaaagtg tctccaccag gcggcttcaa tgatccatcc     2340

taaagaggtg ccccctgagg ccatcttgct ggcagtctac cttgaactgc agaatggtaa     2400

tactcagctg gccttacaga tcatcaaaag gaatcagctg ctccctgcag tgaaaacaca     2460

ctctgaagtg agaaagaagc cagtgtttca gcctgtccac ccgatccagc ccatccaaat     2520

gccggctttc accactgtgc agagaaagtg atacttcact tttggaaaac tgttacctga     2580

gacccagggg agaatttact ggccatttta gttgtatcac agcagaatga ataaaagatg     2640

gtgaaggctg ttaattttga gtcaattcta cccctgacat ttggccaaaa gcttacttaa     2700

aattaaggat ttactaagtc atcatcagct gtttttctta atttcagcca gactattaat     2760

tttgagccat tatgtaatat atgccatagg caattaaaac ataattttat cagaa          2815


<210> 1004
<211> 876
<212> DNA
<213> Homo sapiens

<400> 1004
ggcagcctca cgctcggctc cagcggccaa gagccggaga aagtcctgct ggtgggcggc       60

cgcggggctg agggcgtccg gcatcccggg gccgctccgg cccgggcggc gagagtgccc      120

ggcggtccat gcatccgccg ccgcccgccg ccgcgatgga tttcagtcag aacagcctgt      180

tcggttacat ggaggacctg caggagctca ccatcatcga gaggccggtc cgccggagcc      240

tcaagacacc ggaagaaata gaaagattga cagtcgatga agacctcagt gatattgaaa      300

gggctgttta tctgctcagt gctggtcaag atgtccaagg aacaagtgtg attgcaaatc      360

tcccattttt gatgcgacag aatcccactg agacgcttcg gagagtgttg ccaaaagtca      420

gagtccatga ggatgcacac ttatttatcc agagagtatg gatctcacat atgtttgtcc      480

agagggtgtg actctgtgga ggagaacact tactgtggac agtcccagat gttgaagtca      540

gcacaacaag agaaaaaccc aaatcctgat aagacttgag gatttttcga aaattaaatg      600

caaaatagtt ggggcaaatg ttgctgcggg agtcaagact aagtaataca gtaagaagat      660

atgaagttgg agagcttctc atgttcttcc tttgtataaa gtttgcatac gtacaaaacc      720

caggacttta atgactttaa gagggggcag aattgcatct cttggaagtt aacagactca      780

tgtgaactgg aatgtacgtt gtggccctca caattgattt taatatttat ttgcaaagtc      840

ctttctgttt ctaaataaaa gctgtgcctt ctgaaa                                876


<210> 1005
<211> 1790
<212> DNA
<213> Homo sapiens

<400> 1005
atggaaacaa gagtcttccc ctcccacatg ggaggaaaat tcagtttcag ctcagctagg       60

gatttagtct tactaaagac gcgggaggaa gttctccagc gagcagcttt ccccaacgtg      120

gaaaggacca cgcaaggaca cctgagcttt ccaacagatg ttcagcgcca ggggatccac      180

aggtgggtgc acctgtgtgg aagtaaagct gttgcttatt ctgggagccg aatccgaggc      240

ggagggaggt gggcgcgggg ctatttaaac gttggcggag ggcgggctgg gtcgctgcgc      300

gtctgctcct ccttctcacg tttctcctgc cgtcctaatc ccgccttggc catgagggag      360

atcgtgctca cgcagatcgg gcagtgcggg aatcagatcg gcgccaagtt ctgggaggtg      420

atctctgatg aacatgccat cgactccgct ggcacctacc acggggacag ccacctgcag      480

ctggagcgca tcaacgtgta ctacaacgag gccagcggtg gcaggtacgt gccccgcgct      540

gtgctcgtgg atctggagcc gggcaccatg gactctgtgc gctcggggcc cttcgggcag      600

gtcttcaggc cagacaactt catcttcggt cagtgtgggg ccggaaacaa ctgggccaag      660

ggacactaca ccgaaggcgc ggagctgatg gagtcagtga tggacgttgt cagaaaggag      720

gctgagagct gtgactgcct gcagggtttc cagctgaccc actccctggg tggggggact      780

gggtctggga tgggtaccct tctgctcagt aagatccggg aggagtaccc agacaggatc      840

ataaacacat tcagcatcct gccctcgccc aaggtgtcgg acaccgtggt ggagccctac      900

aacgccaccc tctcagtcca ccagctcata gaaaacgcag atgagacctt ttgcatagat      960

aacgaagctc tgtatgacat atgttccaag accctaaaac tgcccacacc cacctatggt     1020

gacctgaacc acctggtgtc tgctaccatg agtggggtca ccacgtgcct gcgcttcccg     1080

ggccagctga atgctgacct gcggaagctg gccgtgaaca tggtcccgtt tccccggctg     1140

catttcttca tgcccggctt tgccccactg accagccggg gcagccagca gtaccgggcc     1200

ttgactgtgg ctgagcttac ccagcagatg tttgatgcta agaacatgat ggctgcctgt     1260

gacccccgtc acggccgcta cctaacggcg gctgccattt tcaggggtcg catgcccatg     1320

agggaggtgg atgaacaaat gttcaacatt caagataaga acagcagtta ctttgctgac     1380

tggctcccca acaacgtaaa aacagccgtc tgtgacatcc caccccgggg gctaaaaatg     1440

tcagccacct tcattgggaa taatacggcc atccaggaac tcttcaagcg tgtctcagag     1500

cagtttacag caatgttcag gcgcaaggcc ttcctccact ggtacacggg cgagggcatg     1560

gatgagatgg aattcaccga ggccgagagc aacatgaacg acctggtgtc tgaatatcag     1620

caatatcagg atgccacggc cgaggaggag gaggatgagg agtatgccga ggaggaggtg     1680

gcctagaact ctccttttct aggtaaaggg gggaagcagt gtggattctt tactgtgttc     1740

tgacagccat gtgtcactat acgcttgtta atttgtgtct tcacatctcc                1790


<210> 1006
<211> 915
<212> DNA
<213> Homo sapiens

<400> 1006
atggcgaaga ttgagaaaaa cgctcccacg atggaaaaaa agccagaact gtttaacatc       60

atggaagtag atggagtccc tacgttgata ttatcaaaag aatggtggga aaaagtatgt      120

aatttccaag ccaagcctga tgatcttatt ctggcaactt acccaaagtc aggtacaaca      180

tggatgcatg aaattttaga catgattcta aatgatggtg atgtggagaa atgcaaaaga      240

gcccagactc tagatagaca cgctttcctt gaactgaaat ttccccataa agaaaaacca      300

gatttggagt tcgttcttga aatgtcctca ccacaactga taaaaacaca tctcccttca      360

catctgattc caccatctat ctggaaagaa aactgcaaga ttgtctatgt ggccagaaat      420

cccaaggatt gcctggtgtc ctactaccac tttcacagga tggcttcctt tatgcctgat      480

cctcagaact tagaggaatt ttatgagaaa ttcatgtccg gaaaagttgt tggcgggtcc      540

tggtttgacc atgtgaaagg atggtgggct gcaaaagaca tgcaccggat cctctacctc      600

ttctacgagg atattaaaaa agacccaaag cgggaaattg agaagatact gaagttcctg      660

gaaaaagaca tatcagagga aattctgaat aaaatcatct atcacacctc ctttgatgta      720

atgaagcaaa acccaatgac caactatacc actttgccca ccagcattat ggaccactcc      780

atctcccctt ttatgaggaa agggatgcct ggagactgga agaactattt tactgtggcc      840

caaaatgaag aatttgacaa ggactaccag aagaagatgg caggaagcac cctaaccttc      900

cgcacagaga tctga                                                       915


<210> 1007
<211> 500
<212> DNA
<213> Homo sapiens

<400> 1007
caaggacaac ctccacaacc aacaccatgt gtggcagcta ctacggaaac tactatggca       60

cccctggcta tgggttctgt ggctatggag gcctgggcta tggctatgga ggcctgggct      120

gtggctatgg ctcctgctgt ggctgtggct tccgcagact gggctgtggc tatggctatg      180

gctcccgctc cctctgtggc tatggctatg gatgcggctc tggctctggc tactattatt      240

gaggatgcca tgggagactc tcaccctcta tcctgtgata ctgagattca ctaattctga      300

agcccacatg ttctgagatt ttcccttgag tgatgatatc ctgcaatgga agtctaatat      360

ggtctgttgt tgagctacca tctaacctac aaatatcttg aatttccatc atgaaacggg      420

ataaggtaaa attcacctgt cagttctcct ttcatcagaa tgatggtgtc acatcatctg      480

ccttgatgac ttttatgatg                                                  500


<210> 1008
<211> 3087
<212> DNA
<213> Homo sapiens

<400> 1008
tgccagtcat cccaatggct attttgtttt gcagaccacg gtgtgaacac atgaacagaa       60

gacgaaaatt tcttctagcc tcagtacttg ctctccagaa ttcaagtttt atatatccat      120

catgtcagaa gtgcttctct aggataatcc tggtctccaa aagaattttg aaaaccaacc      180

tggacaaggt tcagatgcca gtaacttctt acagcaatgc tctgaccaca aaagaaaagc      240

caaagcacta gtggcttgcc agattgttct accagaccca ggtattgcag gctttactgt      300

cattgactac ttccatcaac ttttgcagac ttttaatttc aggaaacttc agtgtgactc      360

tcaggcacct aacaatcact tacttgcttt agatcactca aatagtgatc tcagcagcat      420

atatacttct gacagcactt ctgatttttt caagtcctgc agcaaggata ctttttcaaa      480

attctggcag ccatcacttg aattcacttg cattgtttca caactaacag ataatgatga      540

tttttcagct tcagaacaaa gtaaggcctt tggtactctt cagcagaaca gaaagtccat      600

ctccattgca gaggccactg gttccagtag ctgccatgat cccattcagg attcatggag      660

ccttgtttca tatatggata aaaagagtac agcagaaaag ttgggtaaag aacttggctt      720

acaagctaag gagctgagtg cagttcacag cagtcatcat gaaattggag ttaatgactc      780

taatttattc tctttggaaa tgcgagagcc ccttgagtca agtaatacaa aatccttcca      840

cagtgcagtg gaaattaaaa ataggtccca gcatgagcta ccatgttttc agcatcatgg      900

tatagatacc ccaactagcc ttcagaagag atctgcatgt tgtccacctt cgttactcag      960

acttgaagag acagccagca gttcccagga tggtgaccct caaatttggg atgatctgcc     1020

attctctgaa agcctgaaca agtttctggc agttcttgaa agtgagattg ctgtaaccca     1080

ggcagatgtc agtagtagga aacatcatgt agataatgac attgataaat ttcatgcaga     1140

ccacagcagg ttatctgtga ctccccagag aactactgga gccctgcata caccacctat     1200

agctttaaga tcatcacaag taatagtcaa agcaaactgt agcaaagatg acttcctttt     1260

caactgtaaa ggaaatctaa gtcctagtgt tgaaaaggag tcacaaccag ataacaaagt     1320

agaggctgtc tctgtaaatc ataatggaag agatatgtca gaatattttt taccgaatcc     1380

ttacctgtca gctctgtctt catcttcaaa agatttagaa acaatagtta ctcttaagaa     1440

gactatcaga atctcaccac acagggagag tgaccattct agtctaaata acaaatattt     1500

gaatggatgt ggagaaatat cagtttcaga aatgaatgaa aagttgacaa ctctgtgtta     1560

taggaagtat aatgatgtct ctgatctttg caaattagaa aataaacaat attgtaggtg     1620

gtccaagaac caagatgaca gttttacaat ttgcaggaaa cttacatatc ctttagaaac     1680

tctttgcaat agtccaaata gaagtacaaa tacattgaaa gaaatgcctt ggggacatat     1740

caataacaac gtaacacaga gctattctat tggttatgaa ggtagctatg atgcctctgc     1800

tgatctcttt gatgatattg ctaaagaaat ggacattgca actgagatta ccaaaaaatc     1860

acaggatatt ttgttaaaat ggggaacatc tttggcagaa agtcaccctt cagagtctga     1920

tttttcactg agatcacttt ctgaagactt catccagcct tcacaaaaat tatccttgca     1980

aagcctatct gactctaggc attcaagaac atgctctcca acacctcatt ttcaatcaga     2040

ttcagaatat aattttgaaa atagtcaaga ctttgttcca tgttcacagt caactccaat     2100

ttcagggttc caccaaacaa gaattcatgg gataaacaga gctttcaaaa aacctgtatt     2160

ttattcagat cttgatggta actatgaaaa aataaggatt ttccctgaaa atgacaaaca     2220

gcaagccagc ccaagctgtc caaaaaatat aaaaacacct agccagaaaa tcagaagccc     2280

tattgtatct ggtgtttcac aaccagacgt tttcaatcac tacccttttg ctgagtgcca     2340

tgaaactgat agtgatgaat gggtccctcc taccacacaa aaaatatttc cttcagatat     2400

gcttggattc caaggcatag gtctagggaa atgccttgct gcctatcatt tccctgatca     2460

acaagagtta ccaagaaaga aactgaaaca tattagacaa ggaaccaata aaggtttaat     2520

taagaagaaa ttaaagaata tgcttgcagc agttgttacg aaaaagaaaa ctcataaata     2580

taactgtaaa agttcaggct ggatttccaa atgtccagac attcaagtct tagcagcacc     2640

tcagctgcac cctattcttg gacctgattc ttgttcagaa gtcaaatgtt gccttccatt     2700

ttcagaaaaa ggcccacctt cagtgtgtga aactcgaagt gcttggtcac ctgaattgtt     2760

ttcataaaaa gtcacctgaa cccaattcct gaacttttaa atctgtttgg aaatgtttgc     2820

cttcaggggt acggaaagca ttctttacat tttgaacact tggagagaag caaattgaaa     2880

acaggactct gctgggagct actgtgcctt ttaaaatata aagccattgt tttccccagg     2940

gttttatcta gaatactatg attaggtagt tgagcacttt atcttatact gtttattgta     3000

ctttaataat attgttaaga ttgtttttga aagtattaat gtttgttaaa atcacatata     3060

catccagaaa taaagacttt gcaaacc                                         3087


<210> 1009
<211> 491
<212> DNA
<213> Homo sapiens

<400> 1009
caagttcctt ctgctccatc ttagggctgt ttttactctg tcctcagccc tccttctaac       60

acccccacat agagacctta attcaaacta aggtaagaaa tgattgtctt tatttcctga      120

aggctttttg aaagcaaaga tgagcaacac tcaagctgag aggtccataa taggcatgat      180

cgacatgttt cacaaataca ccggacgtga tggcaagatt gagaagccaa gcctgctgac      240

gatgatgaag gagaacttcc ccaatttcct cagtgcctgt gacaaaaagg gcatacatta      300

cctcgccact gtctttgaga aaaaggacaa gaatgaggat aagaagattg atttttctga      360

gtttctgtcc ttgctgggag acatagccgc agactaccac aagcagagcc atggagcggc      420

gccctgttct gggggaagcc agtgatccag ccccaccaag gggcctccag agaccccagg      480

aacaataagt g                                                           491


<210> 1010
<211> 4089
<212> DNA
<213> Homo sapiens

<400> 1010
tgtccggaag tcctgagagg gaaacgcccg caaaggctgg tttttaagcg ggagcatctc       60

ttcactcgca gcaagtgcgc gtgcgctgcc tctcagccca aattggaaac atggccgtac      120

ggtcgctgtg ggcgggccgg ctgcgggtgc agcgcctact ggcctggagt gccgcgtggg      180

agagcaaggg atggccgctt ccattcagca ctgccaccca gagaactgct ggtgaggact      240

gccgttctga ggaccctcct gatgagcttg ggccccctct tgctgaacga gccttaaggg      300

taaaagctgt taaactggag aaagaagtcc aagatttaac agtgagatac cagagagcta      360

tagctgattg tgaaaacata aggaggcgaa cccagagatg tgtggaagac gccaagatat      420

ttggaatcca gagtttctgt aaggacttgg tggaggtggc tgacattttg gagaagacta      480

cagagtgcat ttctgaagaa tcggagcctg aggaccaaaa gctcactctg gagaaggtct      540

tccgagggtt gttgctttta gaagcaaagc tgaaaagtgt gtttgccaag catggcctgg      600

agaaactgac acccattggt gacaaatatg acccccatga gcatgaactc atctgtcatg      660

tgccagctgg tgttggggtg cagcctggca ccgtggcatt agtaagacaa gatggctaca      720

aacttcatgg ccgcaccatt aggcttgccc gagtggaagt ggcagtggag tctcagagaa      780

gactgtgaag aggccatcag gaactggatg ttctcccaga gcgcagtcac ctatgtttct      840

tttatttatt aaactaggtt tgtattgtac atgaggtact tcatgtgata tgttttggat      900

ttagtcatat tggctttatt tctaagatat tctattgatt taatgtgacc tgtttggtct      960

catcagaagt cttaccattg ggcatttgaa cagtgtgaca ggtgttccaa tggcctttat     1020

caaaacatgt ttaggaaaat tggtactgtg ataaatttga atccaaaatc cttttaacta     1080

tgggttttca actacatgtt tcttcctagc ggtctctata acaggaattg tgtagtatct     1140

tgtattttgt ggaaaaagga gatggtaggg attggttcaa catttgggta cttagaggat     1200

aaagcttcgt ggtcgtataa atttagatca tttggattga tttttataca catagatttt     1260

caggacttta ccttttgttt tgtttttttc cttttagcca tcttttgttc ttgtaatccc     1320

aactagatag gctttatgct cacatcattg tcccataccc acccctttct catccccatt     1380

tgcaggggct aaaggtctag atgagacttg gaaggcaagg agcatcgaaa tttgagatac     1440

ccaggaccct ttcaagcaag aatggccaaa aagccttgtg ctgtctttgc tcttcaaatt     1500

attttcagcc tccttgtcat ataatcattt caggcaaact gaggcaacac taacagctaa     1560

tgacccagat ggctctattt gggtaattta cctacaactt attccaccag cctttactcc     1620

tctgcccttt tgtcaatttt accttataat cctttattaa atgatgggag gtggtgatca     1680

ggacaaaagt gttaggttcc catgatttct catttcattt attaatagtt aatgctgaat     1740

ttttttttaa gtttcctctg gctctattta tgttactttt tgcgataaga acacttaaca     1800

taagtattct ctcctcttgg caattttttt tttttttcct gtgttgccca ggctgacctc     1860

caactcctgg gcccaagcaa tcctgcctca gcctgccaag tagctaggac tacaggcgtt     1920

caccactgcg cccgcaaagt ttttttgttg tttttttttt taagttggta ctcacaaatc     1980

actacctctg ttatattgac aagctctatt tcctattctt tgtatctgtt aagtcacatc     2040

tgtgtaaaca ttgagctcac cttttatata ttaacctcta gaattaatgg gcctatgtgg     2100

ttttttttca gtcttatagc tggtgttctg taaaagattt gtccaataaa cgacttaatg     2160

aatgatacat cagtcagatt ttaggaaggc agtcaattat ggatatttta atgttggaag     2220

aggccttaat gatcaaatct caccctttct gcttctgaag tatgaaaatc tagtcttttt     2280

aggactggac acaaggaaaa taatctctaa actattgact aaattccagt gagagtatga     2340

atgaagaaca actagatatt aatgtcaatc atttaagatt aatgggcatg caattaagtc     2400

tccatttaag attaatgggc atgcaatgaa gtctccagca gacaatcaga tgttgttgga     2460

tgtctagatt atataggttt aggttgaagt tataaaataa aataaaattc attttccact     2520

ggaactctat gacattcagt ggagtggtgg aaagttaacc tcttatacat tatagataat     2580

tctaagacag cacacaaact tatcaataaa gccatctcct tgtgggcctt accatcttca     2640

tcagatttag acccttaaaa aacaagtaaa tatgcacttt taaaatgcaa tcaaaagact     2700

ggtggttaag cttgtaaaac cagaacatct tttggcattc cactaagtat atattgtaaa     2760

tttaatgaac aatcaaggtt cacaatagga agttgtcttt ttttgccttc cattctgtga     2820

gatttgacag atggtgacaa taagaaaatg agctgattgt aattactctc tgtgtgtttt     2880

tttattgcta gctatcatta ccagttagaa ttaacattaa ttacaattaa caataatttt     2940

aggtatggaa tgttatgatt acctaaagag atgtctctac ctaatgagct caagtgatcc     3000

tcccacctca gcctaccaag tagccaggac cacaggcaag tgcaccacca tgactggcta     3060

gttttgtttt ttggtttttg gtttttggtt tttggttttt tttttttggt tggttggttg     3120

ttttttacag gcggggtctc actatattgt ccaggctaga agaattttct aatggtctat     3180

tacacctccc gttttggcaa gtaaattcag aataatttta ggttcttttg ttattcagta     3240

gttttgcaga cttaaaagtg taaatttaga attagaagat gaagctatag tagtaagaat     3300

ctcaagctga agggctttgg ggagccaaag cagcatatta gagcataggc ttgaacttaa     3360

atctcagctc agtcacctgc aggactttag gcaccagtga tttcaccctt ctgagcctgt     3420

ttctttattc gtaaaatgat tataataatt ctttcacagc gttgtgagga ttaagtgaaa     3480

tgtgttaaat gcctactaca gtaggtgctc agatatttat ttttattttt ttattatgca     3540

cattgttttt cctgcctttt tatggctgtc taaagtctag ggaaaaggga agactggtta     3600

atgatgagta gaaaaaactt gtaagctaat cattcactga cttattttcc ttccattttc     3660

tggtttttaa aattagccac accacaggaa acccacattt ttagatggaa agagcaagaa     3720

aattgtgtca gtgctcttag ttattttcat cttaatggta tagtgaaaag acattgactt     3780

gagatgatac taaggaagct ttggctcact ctcacttgaa gaggggatct tggtgttgta     3840

gtacttggac tgtacaaatg ttttactgac ttttcttact gctgtaaagg aatcaggcag     3900

ttgggtattg atatgttatt tggtgctctc attcatggca aaggatttga taaataaaag     3960

ttctttaaac actaaagcaa aatcaaatga gcaaaactaa ggatgaaatg taatattcat     4020

cagaacaagg atcactgaga aaaaatattc agaaacaact ttaataaaac ctgaattgaa     4080

ataactgca                                                             4089


<210> 1011
<211> 2300
<212> DNA
<213> Homo sapiens

<400> 1011
ttgtttaaca gctggcccgg aagtttaagt gaatatgcgg cttgggctcc aaaagttgct       60

gtacggtatt ttattttaaa gtagaaatct gtccgctttt cacttacgga ggccttacag      120

tgtgtgttct gtgttacttg agtttatacg cactgcagaa tttgtttacc ctgctctttt      180

ggaaacgtat tccggaagcg aaaccctgag taatcggaag tggttaggag tgagagagct      240

gctggatatg cggagggact gggcgggtcg gcttccgaat ggaagaggtc tgtgagaagt      300

taacctggtg ataccgatcc gaagagccta tcaagtgaag ccccctgaaa tacggagaat      360

aagaatctta gaggttgttc agcagaagtc ttggagtgca ttttcagtgg ttaaggtgaa      420

aaaatgacta ctaaaaattt agaaaccaaa gtcaccgtta cttcatcccc aatccgagga      480

gcaggagatg gaatggaaac tgaggaacca cctaaatctg ttgaagttac ctccggagtc      540

caatctagaa agcatcatag tcttcagagt ccatggaaga aagcagttcc atcagagagc      600

ccaggagttc ttcagctagg gaaaatgctc actgaaaaag caatggaagt taaagctgta      660

agaatattag ttcccaaagc tgctataact catgatatcc ccaacaaaaa tacaaaggtt      720

aagtctctgg gacatcataa aggagaattc cttggtcagt cagagggagt tatagaacct      780

aataaggaac tctcagaggt aaagaatgta ttggaaaagc tcaagaattc tgaaagaagg      840

ttactacagg acaaagaagg tctttcaaac cagctccgtg tacagacaga ggtaaatcgt      900

gagttaaaaa agttactggt ggcttctgtt ggggatgatc ttcagtatca ctttgaacgt      960

ctagcccgtg agaaaaatca gcttatttta gaaaatgaag ccctaggtcg aaacacagct     1020

cagctttctg aacagttaga acgtatgtca atacagtgtg atgtatggcg aagtaaattc     1080

cttgcaagca gggtaatggc agatgagtta accaactcaa gagcagcttt acagcgtcaa     1140

aaccgtgatg cacacggggc tatacaagat ctcctaagtg aacgggaaca gtttcgtcaa     1200

gaaatgatag ctacccagaa attattggag gagctcttag tttccttgca atggggaaga     1260

gagcaaactt actcccctag tgtacaaccc cacagcacag cagagctagc attaacaaat     1320

cacaagttgg caaaagcagt aaattctcat cttctgggaa atgttggcat taacaatcaa     1380

aaaaagattc catcaacagt tgaattctgc agcaccccag ctgagaaaat ggctgaaacg     1440

gttctaagaa ttttagatcc agttacctgc aaagagagtt cacctgataa tccatttttt     1500

gagtcttcac caaccacctt acttgctaca aagaaaaata ttggacgatt tcatccctat     1560

actagatatg aaaatataac tttcaattgc tgcaatcact gccggggaga actgattgcc     1620

ctttaacagt caatatgttg gaggcatgct aagaataaac aactaaataa ctgtattaga     1680

aaaaaaagaa acttactaaa tatcataatc tgatgatatg tggtcctgaa ttggctacta     1740

gtttaagcaa ataaactgta agtcatttat gggttagttg gggaataaat ggatatgggc     1800

tggatattcg gtaatatcat taatgaaaag cagattgcag aaatacagta tgatctcagt     1860

attttgaaat tgtaaataca tgtacagaca aatacttaga cagtatgcat actggtgtta     1920

acagtcacaa tttctgggtg atgaaaatgt aacttgaaac cgctccattt ctacaatgca     1980

catttactgt ttctgttata ataaaagggt atgttagaaa aacaaaaagg aggctgggca     2040

tggtggctca tgcctctaat ctcagcactt tgggaggcca aggtgggcgg atcacttgag     2100

gtctggagtt tgagaccagc ctgagcaaca tggtgagacc ccatctctac aaaaaaaata     2160

taaaaattag ccaggtgtgg tggtgcacac ctgtggtccc agctacttgg gaggctgagg     2220

tgggaaaatc acttgaacct gggagggtga ggttgcagtg agctgagatc atgccactgc     2280

actccagcct gggtgacagg                                                 2300


<210> 1012
<211> 2138
<212> DNA
<213> Homo sapiens

<400> 1012
gctgccgcta ctgcggagta gctgcttccc ttcctcctct cccggcggcg gcggcggcag       60

cggcggagga ggaggaggag gggacccggg cgcagagagc cggccggcgg cgcagttgca      120

gcgcggagcc cacgggccgc cggggccgct ccagcgggcg gaagccgagc ccggggccga      180

ccccccgcgc gcggcggagg ccgagggggc gccggggccc ggggcgcgca gccggggggc      240

gggcggcggc gggcggcggg ccgagcggga gccgcatgcg tgtatggatc cgggcgccgc      300

gctgcagagg cgggccgggg gcggcggcgg tctgggcgcg ggctccccgg cgctgtcggg      360

cggccagggc cgccggagga agcagccccc caggccggcc gacttcaagt tgcaggtcat      420

cattatcggc tcccgcggcg tgggcaagac cagcctgatg gagcgcttca ccgacgacac      480

cttctgcgag gcctgcaagt ccaccgtggg tgttgacttc aaaatcaaaa ctgtagagct      540

aagaggaaag aaaattagat tacagatctg ggacacagca ggtcaggaga gattcaacag      600

cattacctca gcttattaca gaagtgccaa ggggatcata ttagtatatg atatcactaa      660

gaaggagaca tttgatgatt tgccgaaatg gatgaagatg attgataagt atgcttcaga      720

agatgcagag cttctcttag ttggaaataa gttggactgt gaaacggaca gagaaatcac      780

caggcagcag ggggaaaagt ttgcacagca gatcactggg atgcggttct gtgaagcaag      840

tgccaaggat aacttcaatg tggacgagat atttttgaaa cttgtcgatg acattctgaa      900

aaagatgcct ctggatattt taaggaatga gttgtccaat agtatcctgt cgttacaacc      960

agagcctgag ataccgccag aactgcctcc accaagacca catgtccgat gctgttgatt     1020

tcctactttg gagacaaagt ggaaatgatt cctggaaagg ggaaaaaacg ttctattctg     1080

cactacaatc attttgacaa tttcctttcg cactttgtaa tccaagtcag agctatacac     1140

taacttgtaa atatgcatat atgcaatcct gggtaagttt tggttataag ttacctattt     1200

ccctccaaat tattatattt cattcattac cccagtgtct agtgtacata cactgggaaa     1260

cctagtactt ctaatatgaa gaatgggaga aatgaaaggt ataatgtttc ttgaaataaa     1320

taatataatt gtccttatta attatattat gaggacagaa gatattctga taagagagaa     1380

cgtggtgctt tgcttaccgt tttaaagaaa atttgtaaaa ctaaagactt tttgaaaaaa     1440

agctatctta agtgcttttt ctttatttac aagacatttc ccccagtggt agcatctgaa     1500

gtattggagt gtttctgcca cgaagcaaag ctccattcat ggccgtcatg gaaggttatt     1560

tattaatgtt acataatggt agaatattac tagttagagg gttggatttg acttggtcct     1620

aaggccacag aatctctctc atggcttcct aagggatgta cctttatgct tttaagaact     1680

acaaagattc aataaagaaa gaaatgtttt tgaaactata gaaaaagatt ttaaaacacg     1740

ctgctgtcct aaacaaatcc tgtttaaagg aattttaaag agatgcattt tactatatca     1800

aagaacatac gtgtatttgc ctaaacactc tgtacctttg taatgataaa acttccccct     1860

tctttacggt gaagcttatt ctgattaagc ctagactgtg ttcttttttt tttttttttt     1920

tttttttttt tttttttttt ttttttttgg tctgatgatg aatttgtgaa ctctatcttt     1980

ggtatatctt ttattaaact gcactgtttt gtttagtcaa ggtaattaag taattatgta     2040

tttgaataac ttggtgtgtc ttgagtgttg tggtatgaaa agcattgtgg tctttctaca     2100

ctaatgaagt gcaaataaaa ttttgtattt atgaatga                             2138


<210> 1013
<211> 1158
<212> DNA
<213> Homo sapiens

<400> 1013
atggctcttc cacatgattc aaacgaaact tcctatttgc tgcctcccaa caatgaggac       60

tggggcaggc aaaccattcc tgactttgtt tatgggcaga aggatctcat ggcagaaggg      120

attcagtggc caaggaatgc acctggcatc ccagatgctc tgccacaatc tccctttgat      180

gctgcactct gctctgcctg gaagcagcgg gtggagctgg ggctgtttcg ctaccgtcta      240

cgggagctac agacccaaat cctccctggt gctgtgggtt tcgtggctca gctgaatgtg      300

gagcgtggtg tgcagaggag gcccccgcag accatcaaga gtgtgaggca ggcatttgac      360

cctgtacagt tcaacttcaa caagatccgg cccggagaag tcctcttccg tttgcaccgg      420

gagcctgatc tccctgggac tctgctgcaa gaagacatcc tggtggtgat caacgtcagc      480

cccctggagt ggggccacgt gctgctggtg cctgagcctg cccgccagct cccccagcgc      540

ctgctgccgg gtgcactgag ggcagggatt gaggctgtgc tgctgagctt acacccgggc      600

ttccgtgtcg gcttcaacag cctgggaggc ttggcctcgg tgaaccacct ccacctgcat      660

ggctattacc tggcccacag actgcccgtg gagcaggcgc caagcgagcc cctggaccct      720

ggaggccatt tgcatctgct ccaggacctc ccagctcctg gcttcctctt ttacactcgt      780

gggccagggc ctgacttgga gtccttgata agcagggtat gtcgggccac tgattatctg      840

actgaccatg agattgctca taacttgttt gtcacccggg gagctccgcc gggaaagaca      900

tcaccttcct cagccctcac aggggtccga gtaattctgt gggcccggaa gtccagcttt      960

gggataaagg acggtgaagc tttcaatgtt gccctctgtg agctggctgg gcacctccct     1020

gtcaaaacat cccaggactt cagcagcctg acagaggcag ctgctgtggc cctcattcag     1080

gactgtcggc tgcccccatc ccaggcagaa gacgtacagg cagcactggt ggccctgatg     1140

tcccaggaag agcaataa                                                   1158


<210> 1014
<211> 555
<212> DNA
<213> Homo sapiens

<400> 1014
tgttgctacc taagccctcc actcccgaca ccatgctctg cgacaacttc cccggggctg       60

tcttcccagg atgctactgg ggcagctatg gctacccgct gggatatagc gttggctgtg      120

gctatggcag cacctactct ccagtgggct atggcttcgg ctatggctac aacggctgtg      180

gggctttcgg ctacaggaga tactcgccat ttgctctcta ctgattggct gaaatccccg      240

aggtgtagca tcttctctcc cttgaaggct gagccccaca tctccaggtt ccccccgtat      300

ccactccttc agtcctcatt tgctcatcaa cctcagagac actgctttcc aacttacctc      360

gagtcccagg ggaggaaaat gaaaaagcag acgcttcctc aagctgcctc ccctggctga      420

tgttctctgg gacattttcg gaaatttgac ctcccacttg tcatgagcta cttttgaatt      480

ttccatgaca ctcatgactt gtgatgaagt catggatatg tctatcaaaa tctcaataaa      540

tttgtctcag ctggt                                                       555


<210> 1015
<211> 2356
<212> DNA
<213> Homo sapiens

<400> 1015
gaaccctgaa gtcggtgtct gctgcgttca cggcaggatt cggttaggag gaacagcaca       60

gcatgctggg ctctggattt aaagctgagc gcttaagagt gaatttgaga ttagtcataa      120

atcgccttaa actattggag aaaaagaaaa cggaactggc ccagaaagca aggaaggaga      180

ttgctgacta tctggctgct gggaaagatg aacgagctcg gatccgtgtg gagcacatta      240

tccgggaaga ctacctcgtg gaggccatgg agatcctgga gctgtactgt gacctgctgc      300

tggctcggtt tggccttatc cagtctatga aggaactaga ttctggtctg gctgaatctg      360

tgtctacatt gatctgggct gctcctcgac tccagtcaga agtggctgag ttgaaaatag      420

ttgctgatca gctctgtgcc aagtatagca aggaatatgg caagctatgt aggaccaacc      480

agattggaac tgtgaatgac aggctaatgc acaagctgag tgtggaagcc ccacccaaaa      540

tcctggtgga gagatacctg attgaaattg caaagaatta caacgtaccc tatgaacctg      600

actctgtggt catggcagaa gctcctcctg gggtagagac agatcttatt gatgttggat      660

tcacagatga tgtgaagaaa ggaggccctg gaagaggagg gagtggtggc ttcacagcac      720

cagttggtgg acctgatgga acggtgccaa tgcccatgcc catgcccatg cctatgccat      780

ctgcaaatac gcctttctca tatccactgc caaagggacc atcagatttc aatggactgc      840

caatggggac ttatcaggcc tttcccaata ttcatccacc tcagatacca gcaactcccc      900

catcgtatga atctatgaca ttaatgctga taagaatatc tcttctgcac agattgttgg      960

tcctggaccc aagccagaag cctctgcaaa gcttccttcc agacctgcag ataactatga     1020

caactttgtc ctaccagagt tgccatctgt gccagacaca ctaccaactg catctgctgg     1080

tgccagcacc tcagcatctg aagacattga ctttgatgat ctttcccgga ggtttgaaga     1140

gctgaaaaag aaaacatagg tctcttaaac caggcaactt tcacgttttg ggagttgaga     1200

ctgagcaatt tctccttgta acaaagaatc tccatgaaat tctgtttcat ctgttaaccg     1260

tcactcagca caacactccc tctgggctct cttcctgctc ctccagattc tgctgctttc     1320

cagttctctg ttgatcctga gactaacaat tggagactga ggccagagca actggctcct     1380

ggcagctgtg cttgtccgtt tcctgtcaga gtgatcccag gtttcctcct ggcccgtccc     1440

atggtccctc cacaggagtg tgagaggatg ggggaagcac tgtgggaaga ccaccaaaga     1500

tggctggaca gtgggagaga gcacgttgtg aagcatccca gcctcgtgtt gaggttccag     1560

acttagaaac agacccctct gtacaggggg attgtggtga gtgagaatca aggccacctt     1620

gtgtgttttc tcactctcga atgcaagtgg gagagggaaa atgactcggg acgccattgt     1680

aacggttcct ggaagctggg ccctctcatt ggcatataca gtactcctcg ctgcagggca     1740

ctgtcccacc gggatccagt tgcaaagttt gtcttgacag ttgaaggcct cgcttagttg     1800

tactggattc tcagggagcc ctctgtggcc ttttgctttg cgtgctgttt cccttgtacc     1860

agagggcggc accgtggaaa ttctgttttc cctgtagcat attgtgttgg attgcattac     1920

tggcagagaa aggacaaggt gccattcaag tcctagggtg ggcttccagc tgccttaata     1980

gaagtactca agtcttttgg gtagtgagct ggaaagccta caggaaaaga ggggtacctg     2040

ttttcatttg aaaactttga ttcatggaac ctttaaaact aatctcagaa aaatttttgg     2100

tgcccatgca gctgtagttg ttcactgctt tcctggatgg atgggactct tatgtcataa     2160

cttctgttac tcctttggcc catagctaag gtcatccttc cccacagggg tggctttggg     2220

attggatgat acagcttttg cttctgtgta gtatacctgt acatacttgt ttcaggcagc     2280

ctttctttaa tgttttcagt tggtttgtat tctgtagctc agtagctgct aataaagtta     2340

aagatcctgt gtcctg                                                     2356


<210> 1016
<211> 802
<212> DNA
<213> Homo sapiens

<400> 1016
aaacccgctc tcgcccgcgg atgggcgcgc agctgtgacg tcacggcgtc gttggtaagg       60

ggctggcggc cggggagctg cgtagctccc ggccccgcgg ccatgcccaa gcggagctgc      120

cccttcgcgg acgtggcccc gctacagctc aaggtccgcg tgagccagag ggagttgagc      180

cgcggcgtgt gcgccgagcg ctactcgcag gaggtcttcg agaagaccaa gcgactcctg      240

ttcctcgggg cccaggccta cctggaccac gtgtgggatg aaggctgtgc cgtcgttcac      300

ctgccagagt ccccaaagcc tggccctaca ggggccccga gggctgcacg tgggcagatg      360

ctgattggac cagacggccg cctgatcagg agccttgggc aggcctccga agctgaccca      420

tctggggtag cgtccattgc ctgttcctca tgcgtgcgag ccgtggatgg gaaggcggtc      480

tgcggtcagt gtgagcgagc cctgtgcggg cagtgtgtgc gcacctgctg gggctgcggc      540

tccgtggcct gtaccctgtg tggcctcgtg gactgcagtg acatgtacga gaaagtgctg      600

tgcaccagct gtgccatgtt cgagacctga ggctggctca agccggctgc cttcaccggg      660

agccacgccg tgcatggcag ccttccctgg acgagcgctc ggtgttcaca ctgaactgtg      720

gggtcgacgg gaggggtgcc ttttacatgt tctattttgt atcctaatga cagaatgaat      780

aaacctcttt atatttgcac aa                                               802


<210> 1017
<211> 2972
<212> DNA
<213> Homo sapiens

<400> 1017
aactacaaaa ttgaaagtag agaggagggg gcagccaatg gaaaaaaaaa tttgcacagc       60

agccaatcct cctgcggcgt tttgtgcctt tgcccaacag gaaaatgtgt ctcatgcaga      120

ggggcgttac ccagtctcca atgggcggga gccggtggaa cggaggagcc aatgagtgcg      180

agatgttgag tgacagctgt ccaatggagg ccctccgtgc tagtacggct tgcggcttaa      240

gcgccgccgc ggtctgcgga atgtcaacta ttcaacatgg aggcggaggt cgataagctg      300

gaactgatgt tccagaaagc tgagtctgat ctggattaca ttcaatacag gctggaatat      360

gaaatcaaga ctaatcatcc tgattcagca agtgagaaaa atccagttac actcttaaag      420

gaattgtcag tgataaagtc tcgatatcaa actttgtatg cccgctttaa accagttgct      480

gttgagcaga aagagagtaa gagccgcatt tgtgctactg tgaaaaagac tatgaatatg      540

atacaaaaac tacagaagca aacagacctg gagctgtcac cactgactaa agaagagaaa      600

actgcggcag agcaattcaa atttcacatg ccagatttat gaagaaatgg acttggaaag      660

gaaattctaa cagagaagag cttaattccg gagaaattta ggaagatgtc ttgttaaccc      720

ttgatgtcta gagattgggg gctggtgaag ggggtttggc ttcaatgact ggataatgat      780

atctttcatg agagagatta taagaagaag ggcagataat atatgaataa agttcagcca      840

aaaggatcaa atgagaataa aacgatttaa atatatgtac acacgcatgc acacacacac      900

ttagtcttgt aatttcaggc cagaaattct caacactatt ttgcatctgt tttctttttc      960

taagtcatga taatatagat gttctggtct atcataaaag aatgtttatg tacatttcag     1020

tcattcggta tgtggctttg taaattaaag tataggcaaa acatttgtgt tatacatgat     1080

atataatttc attttgtaaa tgttgattgc acatgtggtc acattattgt tgagactgct     1140

tttatgtgac ctgtagtctc ccacagaacc taaagtaata agctggcttt tctgtgatag     1200

ccacgtttgc gtatttcttt ccctatttcc cttgcctgct aatgttgaac agcatgaact     1260

tgctttctga tgctgtttta gactgtccct gttgtatctc aataatatct ttgttttcct     1320

tcagccttta ttactataat tgttcattct acatgaaagc taggaaactg aaattagaag     1380

agcacttatc tgctacttgc cagttttgcg tgagtgtgtt atatgtatgt gtcaatttcc     1440

ctttaaaata actatttatt ttaaaataac tattggcaat aaggaaactg ttcaaagtag     1500

aggcagatct tgatagaaag atgttaatca cagggttgtt tataatagca atatacatac     1560

acatttggct agtactaggt gaataggaaa ataaatcatg ctgtatgtat acaataagag     1620

gtcaagttgc caataaatta ttactgttaa tgttctggga aatgctgaaa ctatgctaag     1680

tgggggagag ggaaagcagg tattgcagtt ttgtagtgaa gattgggctt tggagtcata     1740

tctgagatgt aagtagcagc ttttaaattc tagctatgac cctgtgcaga tcacttaact     1800

tttgagtgtc aggatgtttg gaaggacaag acaggaaagt gttttaatac agggttcagt     1860

atttagtaag ccttcaataa gtgatattac atacatgtaa taaaaactaa gcattgaaag     1920

gactaggaaa aatgcatcaa atgttagttc tgcaggttat agaattatac ttttatgtaa     1980

ttttaaaatt tcagttatga acatgtttgt ccattaacaa acttataata gctgaaaaac     2040

agggttgtga gaacagcttc agttaaaatt gtcctgtcta gtttgaatat ttcaagaaca     2100

gaaagccttt tttttttttt tttttttttt gagacggagt ctcactctgt tgcccaggct     2160

ggaatgcagt ggtacgctct cagctcactg caacctccac ctcccaggtt caagcagttc     2220

tctgccccac cctcccgagt agctgggatt acaggcgccc gccaccacgc ccggctattt     2280

ttttgtattt ttagtagaga tggggcttca ccatcttgac caggctggtc tttaactcct     2340

gatggtgatc cacccacctc ggcctcccaa agtgctggga ttacaggcat gagctaccgt     2400

gcctggcccc ctttttttta attacagaga aataagttac accttagtat cagatattaa     2460

ttttcttcag tgttcaggca attagtattt agaaagctct tgtcatgaga tggctctggg     2520

atgtgatgat gattgttggg attgaaaaaa cggtagtatc atggagagat cataataaat     2580

tcttagtatt aaaagtggtt ttgctttcag ttagggagaa aaattagatt gtactatttt     2640

tcctctatga tttccttcag ttatcttcca aatgttgttt tttccccaca gcccccttaa     2700

cattgttctc tatgcacttc tcaatacatt ttcatttgtt tctcaagcct ctttgtggat     2760

gactcctaaa tataacttct tccactagct ctagatccgt atttccaata aaatccccta     2820

cctgaatatt caagttaaac atgtccagaa tacttactga ttttattgtt aatagccact     2880

attctgttgt ctggaattaa aacctgtata actaatttgc atccctttat cttcttagtc     2940

aataaaacct acaatcctct ttctaaaatg gt                                   2972


<210> 1018
<211> 7043
<212> DNA
<213> Homo sapiens

<400> 1018
gcgcagaggc gtcacgcact ccatggtaac gacgctcggc ccgaagatgg cggccgaatg       60

gggcggagga gtgggttact cgggctcagg cccgggccgg agccggtggc gctggagcgg      120

gtctgtgtgg gtccgaagcg ttttactcct gttgggcggg ctccgggcca gcgccacatc      180

tactcccgtc tccttgggca gttcccctcc ctgccggcac cacgtcccct ctgacactga      240

ggtcataaat aaagttcatc ttaaggcaaa tcatgtggtc aagagagatg ttgatgagca      300

tttaagaatc aagactgtct atgataaaag tgttgaagag ttgctccctg agaaaaagaa      360

tcttgtaaag aacaagcttt tcccacaagc gatttcttat ttagagaaga cttttcaggt      420

ccgtcgacct gcgggcacta tcttacttag cagacaatgt gcaacaaacc aatacctccg      480

gaaggaaaac gatcctcaca ggtactgcac cggggagtgt gccgcacaca caaagtgcgg      540

ccccgttatt gttcctgagg aacatctcca gcaatgccgg gtctaccgtg ggggtaagtg      600

gcctcatgga gcagtgggtg tgccagacca agaaggcatc tcagatgcag actttgttct      660

ttacgttggt gctctggcca ccgagagatg cagccatgaa aacatcatct cttatgcagc      720

ctattgtcag caggaagcaa acatggacag gccaatagca ggatatgcta acctgtgtcc      780

aaatatgatc tctacccagc ctcaggagtt tgttgggatg ctgtccacag tgaaacatga      840

ggttattcat gccctgggtt tctctgctgg gctgtttgca ttctaccatg ataaagatgg      900

aaatcctctc acttcaagat ttgcagatgg cctcccacct tttaattata gtctgggatt      960

atatcaatgg agtgataaag tagttcgaaa agtggagaga ttatgggatg ttcgagataa     1020

taagatagtt cgtcacactg tgtatctcct ggtaacgcct cgtgttgttg aggaagcacg     1080

aaaacatttt gattgtccag ttctagaggg aatggaactt gaaaatcaag gtggtgtggg     1140

cactgagctc aaccattggg aaaaaaggtt attagagaat gaagcgatga ctggttctca     1200

cactcagaat cgagtactct ctcgaatcac tctggcatta atggaggaca ctgggagaca     1260

gatgctgagc ccttactgtg acacgctcag aagtaaccca ctgcagctaa cttgcagaca     1320

ggaccagaga gcagttgccg tgtgtaattt gcagaagttc cctaagcctt taccacagga     1380

ataccagtac tttgatgaac tcagtggaat acctgcagaa gatttgcctt attatggtgg     1440

ctccgtggaa attgctgact actgcccttt cagtcaggaa ttcagttggc atttaagtgg     1500

tgaatatcag cgcagctcag attgtagaat attggaaaat caaccagaaa tttttaagaa     1560

ctatggcgct gaaaagtatg gacctcattc cgtttgtcta attcagaaat cagcattcgt     1620

tatggagaag tgtgagagga agctgagtta cccagactgg ggaagcggat gctatcaggt     1680

ttcttgttct cctcaaggtc tgaaagtttg ggtccaagat acttcatatt tgtgtagtcg     1740

ggctgggcag gtcctccctg tcagtatcca gatgaatggc tggattcacg atggaaacct     1800

gctctgccca tcatgttggg acttctgtga gctctgtcct ccagaaacag atcctccagc     1860

cactaacctg acccgagctc tgccacttga tctttgttcc tgttcctcga gcctggtggt     1920

caccctctgg cttctgctag gcaatctgtt tcctctgctg gctggatttc ttctgtgtat     1980

atggcactag gaatggaaaa gtggatcttc aagatattct tttatgttat gttcttgtga     2040

acaaagcaca aagtttgagt gagtgccaac ctatgcagat ggtagaagtg gcattcctgg     2100

ctttggcttg gaagaattga cgaccatcag accttgaagc agaacttcac agcagcctgt     2160

cctcatcagc aacccaacca ccttcatcag caacccaacc accttcatca gcaacccaac     2220

cacctcgtca gcaacccaac cacctcgtca gcaacccaac cacctcgtca gcaacccagc     2280

caccttcatc agcaacccaa ccacctcatc agcaacccag ccaccttcat cagcaaccca     2340

accacctcat cagcaaacca accactttca tctgcaaccc aaccactttc atcagcaact     2400

caacaccttc atctgcaacc caaccacctt catcagcaaa ccaaccacct tcttcagcaa     2460

cccaaccacc tcatcttgga gaaggagaag gaactgcaag ccaccaagtc ttcatttttc     2520

agggtttgta atcttcccaa agttttcctt tgaaaatagg ataatgggtg gaattttcag     2580

agtgattaca tacctcaaca tttttattaa catacaacaa tgggaaagtt catcatccat     2640

atactgcagt cacttaaaca acagccaatt attgcaagat tagaattgga gatcttgtcc     2700

tcaaaagtat aaattgtcct ttgagttata gaaaataatg gaattgggat ttctacatat     2760

cattattata cctattttaa atttaatggc agccaggcat ggttccagct acttgggagg     2820

ctgaggcagg aggatcgctt gagcccagga gttcaaggct gcagtgagct atgattgcac     2880

cactgtattc cagcctgcac gatagagtta gaccctgtat cttaaaaaaa aaaaaattaa     2940

tggctggtat atagtaaact taattcactg ttcccattgt tctaaagaat ttttttaaat     3000

aatgtttcat taaatcttat gatttaaccg tgcttgccct ttttgccagc tatgtggcag     3060

tttacggcag aactgctgtc agtgtgctgg tagccctcta ttcatccctc ctcagagccc     3120

agcttccaga actgctatca ctgtgctggt agccctctgt attcatccct cttcagagct     3180

cagcttctgg ttgtattctc catgagttta ataatgacat gaaaaaatgt ggaagccgag     3240

agagtaaaat actctgccct gtaaaaacat ggaagacatg caaacagaaa aaaaataatt     3300

gtattgtttt agataatact taagacaact gtgaaacaac aaaaacacaa ctattccttt     3360

gtgaccgatg aagataaaaa gaaattctgg taaagacggg tatgcagttt tttaaaatgg     3420

gttaagaaat tgttgcagaa gaatttctaa catctgaaaa tggttttatg tttaagaagg     3480

atggtctgaa ttgtgtacta atagcaaggt ataagtttgg tgtagagcct atccagtagc     3540

gtccactgta ccacttttaa gtaagactca gtccacagaa gctggaagat tgccttcgct     3600

ttaaatatcc tttaccttct gcatttgaca ctcctcctgt tactacatag attccggtcc     3660

ccagaagcaa ttttacactg gtactagagc ttaccagccc catttagtaa tttttaatgg     3720

ctagatgagg tttaacaaga atatgaaaag aaaaaagaaa aaatatattc atgaatgata     3780

ggcgatgccc attctttctc tcaagctaat gaagtcctat ggcattctaa ccacaaccct     3840

cggacagact cctcctattc ctccatggca ttgtaaccac aaccctcgga cagactcctc     3900

ctattcctcc atggcattgt aaccacaacc ctcggacaga ctcctcctac tcctccatgg     3960

cattgtaacc acaaccctcg gacagactcc tcctactcct ccatggcatt gtaaccacaa     4020

ccctcggaca gactcctcct actcctccat ggcattgtaa ccacaaccct cggacagact     4080

cctcctattc ctccatggca ttgtaaccac aaccctcgga cagactcctc ctattcctcc     4140

atggcattgt aaccacaacc ctcggacaga ctcctcctat tcctccatgg cattgtaacc     4200

acaaccctcg gacagactcc tattcctcca tggcattgta accacaaccc tcggacagac     4260

tcctcctatt cctccatggc attgtaacca caaccctcgg acagactcct tctgttcctc     4320

ctttcctcgt ccttccctgc ttttcgtcca ttcagcatat agctattcag tactccattg     4380

aagaaattat gctaagtgag caaagcaaca taattactaa gaattaattc tgattatttg     4440

gcactagagc caacagcaac cccagcacag aggaaagtcg cttttttttc aaatgcataa     4500

atttaaagta tgtatttgca tgcagtttta aatgggaggt atttgtcatt gtgaaaagct     4560

gggaatctca aacatagtca acttaactaa aaagaagcta atacaggttg agcattccta     4620

atccaaaaat ccagaatcca aattgctcca aaatctgaaa ctttctgaat gctgacctga     4680

tactacaagt agaaaattcc acatacaagt acttaacaca aactttgttt catgcacaaa     4740

ctactaaaaa tattgtataa aattaccttc aggcagtgtg tgtagttata tatgaaacat     4800

gaatttcatg tttagacttg ggtccatgcc caagatacct cattaggtat ctgtaaatat     4860

ccgaaatcca aaaaaaagtc tgaaatctga aacacttctg gtcccaagca tttcagtaag     4920

tgatgctcaa cctgcgtaat ggtctgcggg ccagtgctca ttttctgcct atgttgtaca     4980

tactttaaat tgtgtaaatt aaaagtcaaa gcaaagagtc tatttttaaa gaaacttaca     5040

ataatctaaa catatacttc ttatgattat gaatcatcct gcaaagctga atgaagaatt     5100

ttaccaaaaa tacaatgaat taatcatata tttgagagtc acagtgatag gttcgactat     5160

attttgactg ttgtgtagtg gcaccgttta ggtagtattg tttctgagca tggtgctttt     5220

tatacttgaa atatattttt gctttatttt ttattgatat aattatattt gcactaatgg     5280

ctttctgaag aaaatattat agatgacatt ttttgtatat atatttatta agcttgggaa     5340

cctggtcgcc cagtgttttc tctggacaaa tgtgaaactg gataaagtat ggataaagtc     5400

ttgagttcct cagggtaact gtgttgatgt ctcccgtcct cttcagtaag gcttgaatat     5460

gattttactc atcattgatt ctgcatagtg tacccagcaa gacttagaag gacactgaac     5520

ctgtcagaga ttttaagagg cacattttag tcactttgaa tatggtagtg gtgggcgcgg     5580

tgactgaagc ctgtaatctc agcacttcgg gaggccaagg caagcagatc acgagatcag     5640

gagtttgagg ttacagtgag ctgatcgcac cactgcactg cagcctggat gacagagtga     5700

gactttcttg ggaaaaaaaa aaatgacagt gaagcagact tttagaatcc gagatgtcat     5760

tgcagaatta ttggtataaa attcagctgc aaagtgaaga aattgaaatg gcccacacgt     5820

tgatatcctg tggcaggtta tacccttcat gttagcaaag acgaagccac gtcgctgtgt     5880

taagagggac aggctgggcc ggctgcagct gtagtggaag tgagggacac agggaaggaa     5940

tggggagcag caatttgggg acagtagact ggagtcactt tctgactcaa aaagggtcaa     6000

gtacttatta aaaactatct tggttttctg ttcagactta ggctcatttt gatcatttta     6060

aggtcccagt tgtcaaaaat atcaagtgaa tttgtctcag gttttcagaa acaaaattta     6120

caggaaggaa gcaaaagcca tgtcagtagc cttgagctga cagctttaaa gaaactggca     6180

aacaggtagg ttgtcctcat atagatcctt ccagtattct gaaaaacatc cttttatttc     6240

ttaaaaccag taacccttac atttttccta taggatagtt atttttgttg agatcaaata     6300

gacattctat aaatgttata aattatgctt gcagttactc agcctatcta ggcttaaggt     6360

ttatcaatat ttgaagttga aacatcatct tatgaggttt agttttagga agataaataa     6420

atatatcaaa gtatttcata aagttgtatc aatgttcctt ctaacattag aagacttact     6480

gactgaggcc atctgtgaac gactaggtga tctcagaatc cttccagctc taataccctc     6540

tgactaacac tcacccagaa ttgctgtctg tgctggctgt gatctgcctc caggagcata     6600

cgccatcctg cgtgctgtgt ccatcacagt gtctgtgctc ggtgccttac cactgtccgt     6660

gtccttggac gctgactgga cagagaggag cctgtctctc agggcacatg agtcgtcgtg     6720

gcaggaggag acgggcctca gtcacagtgt cacagaccct tgtcacagtg gacactagtc     6780

attcctgcca tgtccttgca gcccaggagg actaaaaaga ttttaatgaa gtctgtgtta     6840

ctcattctga agaaaagaac ttacctgaga ggagtaatat ttttttaata tatattgggt     6900

cagggacagg gatggagtgg ttgttttatg tttacatttt taataagtaa aatagaagat     6960

ttaagaacta atatttatgg tattgaactt taagtgtgat atattcctta gaaaaacaca     7020

actttaataa aaatggaaac taa                                             7043


<210> 1019
<211> 592
<212> DNA
<213> Homo sapiens

<400> 1019
actccgccag ggggcgctgt gtggctcccg agtaggctca gagcgaccgt ggccgggcgg       60

aagcggcttt ctggcctaag ctttaacagg cttcgcctgt gcttcctgtt tcctctttta      120

ccaaggaccc gccaacatgg gccgcgttcg caccaaaacc gtgaagaagg cggcccgggt      180

catcatagaa aagtactaca cgcgcctggg caacgacttc cacacgaaca agcgcgtgtg      240

cgaggagatc gccattatcc ccagcaaaaa gctccgcaac aagatagcag gttatgtcac      300

gcatctgatg aagcgaattc agagaggccc agtaagaggt atctccatca agctgcagga      360

ggaggagaga gaaaggagag acaattatgt tcctgaggtc tcagccttgg atcaggagat      420

tattgaagta gatcctgaca ctaaggaaat gctgaagctt ttggacttcg gcagtctgtc      480

caaccttcag gtcactcagc ctacagttgg gatgaatttc aaaacgcctc ggggacctgt      540

ttgaattttt tctgtagtgc tgtattattt tcaataaatc tgggacaaca gc              592


<210> 1020
<211> 2001
<212> DNA
<213> Homo sapiens

<400> 1020
agaattccgt ggctttggaa aataaaactg ctgttatagc tcttctgggt atttgagaaa       60

tgcacttgtg aagggttaga gttgaatctt ttgatgcgaa agtcgggttt tcctgatact      120

gggattccgg gattccaggt gttggggtgg cccaattcct gcgagaagca atagcgggcg      180

gtaacatgag gagcacggtg cgtccagcga gtccttccgc ctggggccct gccgaccccc      240

tgcctgcgcc cccaggactc tggcctcacc cggccgtgcc ggggcctctg tgacgcggcg      300

ttccaggcac tcggccccgg ccgagcccgt agctagagcg gctcagagac aggaggcggc      360

ggcagcagcg gcggcatgaa ccactgccag ctaccggtgg tgatcgacaa cggctcggga      420

atgatcaagg cgggcgtggc tgggtgccgg gagccccagt ttatctaccc gaacattatc      480

ggccgcgcca agggccagag ccgcgcggcc cagggcgggc tagaactctg cgtgggcgac      540

caagctcagg actggaggag ctcgctgttc atcagttacc cagtggagcg tggtctcatt      600

acttcatggg aggacatgga gatcatgtgg aagcatatct atgactataa cctaaagctg      660

aagccgtgtg atggcccagt cttgattact gagccagcgc tgaacccact ggccaaccgg      720

caacagatca cggaaatgtt ttttgagcat ctgggtgttc ctgccttcta tatgtccatc      780

caggctgtgc tggctctctt tgctgctggc ttcactactg gccttgtgct gaattcaggt      840

gctggggtta cccagagtgt gcccatcttt gagggttact gtctgcctca tggtgtgcag      900

caactggatc tggcaggcct tgacctcacc aactacctca tggtgctaat gaagaaccat      960

ggtatcatgt tgctcagtgc ttcagacaga aagattgttg aagacatcaa ggagagcttt     1020

tgttatgtgg caatgaacta cgaagaggaa atggccaaga aacccgattg tctagagaaa     1080

gtttaccaac tacctgatgg gaaggtcatc cagctccatg accagctctt ttcttgtcca     1140

gaggccctct tctctccgtg tcatatgaac cttgaggccc ctggcattga taagatatgc     1200

ttcagcagca taatgaaatg tgatacaggc ctgaggaatt ccttcttttc caatattatc     1260

cttgccgggg gatcaacctc tttccctggt ttagacaagc ggttagttaa ggatatagca     1320

aaggtggctc ctgccaacac cgctgtgcaa gttatagctc ctccagaaag gaaaatatca     1380

gtgtggatgg gaggttctat tcttgcatcc ttgtctgcct tccaggacat gtggatcact     1440

gctgcagaat ttaaagaagt tggacccaac atagtacacc aaagatgctt ctgaaataca     1500

gataaaatgg ttggaagaaa atgttttgag tatatgtgac agaaaacttt ggatattata     1560

tgtttctggg agaagagaaa atacttcacc tattgggatg ccaatatttc tgttgtattt     1620

ctataatggg tttgggggat aataatggtg aagctcaaga acagatgtct attgagtaga     1680

accaagttaa aataatgttt cccatagtgt ttcttctata acttgacgtt ggtgagctta     1740

tatttccctt ggaagagagc atttgtggta caatatgcta tgtgccaaat gagtgataag     1800

atttaagctt attgaagttt agggaaagaa ggttgctgtg gtgaggaacg agactccata     1860

gcagaggtat gccatcatgg aaggggtggc attgggatgg agcgcagata tccaggcaag     1920

catactaaaa tgaacaagtt gctaaagatg agaatgaaca aagcatattc agggcatgtt     1980

taatagactg attttgtttt t                                               2001


<210> 1021
<211> 3731
<212> DNA
<213> Homo sapiens

<400> 1021
agtccccgag gtcacaaggc agtggcaggt gtctgtagtc ctcgggttga ctgcagctcg       60

cggtggtccc tctccgagcc caggaagcca ctccagtgcc gagggagagg cctgggagcg      120

ctcggagtgt gcgcggactg gagaaggggg aggtggcgga gtgattcgta gagtaaattc      180

ggtaccgagg ggcggggtcg gggatttgaa tcggtcggcg ggcggaggag gcgggtggag      240

gaggctgccg ggcagagcgc aggccaggat cagcgcaggc tgtgagtcca ggtcagccgt      300

cgggacctcg ggctccgggt tcgaagagcg gctcccggct gcgggtgctt tgccaggaga      360

gcccttccgg acagaggagc cggggtctgg aaggagcggc cgacgcgacg ctcgcctgcc      420

acggggctct gggagtaagc ctgtctgcct ggcgggcctt caggtgcggc gtgagagatg      480

gatgccaatt caaaagacaa gccccctgaa accaaggagt ctgcaatgaa taatgctgga      540

aatgcctctt tcattttggg aactgggaag attgtgactc ctcagaagca tgccgaatta      600

cctcctaatc cttgcacacc agatactttt aaatcacctt tgaacttttc cacagtaacc      660

gtagagcaat tgggaattac acctgaaagc tttgttagga actctgcagg aaagtcatca      720

tcctacctta aaaaatgtag acgacgttct gcagtcggtg ctcggggctc tcctgaaaca      780

aaccatctga ttcgtttcat tgctcggcag caaaatataa agaatgctag gaaatctcct      840

ttggcacaag attctccttc ccagggcagc cctgcactgt atcgaaatgt taacacttta      900

agagaacgaa tatcagcctt ccagtcagct tttcactcca taaaggaaaa tgagaaaatg      960

accggctgtc tggaattctc agaggcagga aaagagtccg agatgacaga cttgaccaga     1020

aaggaaggtc tcagcgcttg ccagcagtct gggttccctg cagtgttgtc ctccaaacgt     1080

cggagaatat cctatcagag agactctgat gaaaatctga cggatgctga aggaaaagta     1140

attggtctcc agatattcaa tattgataca gacagagcat gtgcagttga aacttctgta     1200

gatctttctg agatatcatc taaacttggt tcaacacagt ctggattttt agttgaagag     1260

tctcttcccc tttcagagct cacagagact tcaaatgcac taaaggttgc tgactgtgta     1320

gtgggcaaag gatcaagtga tgccgtttcg cctgacacgt tcacagcaga agtgagctca     1380

gacgcagtcc ctgatgtcag gtcaccagct actccagcct gcaggaggga ccttcccacc     1440

cccaagacct ttgtacttcg ttctgtactg aagaaaccct ctgttaagat gtgtctagag     1500

agcttacagg aacactgtaa caacctctat gatgatgatg ggactcatcc gagcttaatc     1560

tcaaatctcc caaactgttg caaagagaaa gaagcagaag atgaagaaaa ttttgaagca     1620

cctgcctttc taaatatgag gaagaggaag agagttactt ttggagagga cttaagcccg     1680

gaagtgtttg atgaatcttt gccagcaaat actccattgc gtaaaggagg aacacctgtt     1740

tgtaaaaaag acttcagtgg tctcagttcc ctgctgcttg agcagtcacc tgttcctgag     1800

ccattacctc aaccagattt tgatgacaag ggggagaatc ttgaaaacat agaaccactt     1860

caagtatcat ttgccgttct cagttctcct aataaatcat caatctctga gaccctttca     1920

ggcactgata cctttagttc ttcaaataac catgagaaaa tatcctctcc taaagttggt     1980

agaataacaa ggacttctaa cagaagaaat caattggtca gtgttgtaga agagagtgtt     2040

tgcaacttat tgaatacaga agttcagcct tgtaaagaaa agaaaattaa taggaggaag     2100

tctcaagaaa caaagtgtac aaagagagca cttcctaaga agagtcaggt tttaaaaagt     2160

tgcagaaaga agaaaggaaa gggaaagaaa agtgttcaga aatctttata tggggaaaga     2220

gacattgctt ctaagaagcc cctcctcagt cctattcccg agctgcctga agtccctgag     2280

atgacacctt ccattccgag catccgaaga ctgggttcag gttatttcag ttcaaatggc     2340

aaactggaag aagtgaagac tcctaaaaat ccagtgaaaa gaaaggatct tttgcgtcat     2400

gacccagatt tgcatatgca tcaaggctat gataaatatg atgtctctga attctgctct     2460

tatataaaaa gttcctcatc gcttggcaat gctacttctg atgaagatcc aaatacaaat     2520

ataatgaaca ttaatgaaaa taaaaatatt ccaaaagcaa aaaataagtc agaaagtgaa     2580

aatgaaccaa aagctggaac tgacagtcct gtttcttgtg cttctgtaac tgaagaacgt     2640

gtggcatcag atagtcccaa acctgctctg accctgcagc agggtcaaga attttctgct     2700

ggtggtcaaa atgcagaaaa cctttgtcag ttctttaaaa tttcaccaga tttaaacata     2760

aagtgtgaaa gaaaggatga cttcttagga gctgcagaag gaaaactgca atgcaatcgt     2820

ttaatgccta attcacaaaa agactgtcat tgtttaggag atgtcttaat tgaaaatacg     2880

aaagaatcta aaagccagag tgaggatttg ggaagaaaac ccatggaaag tagcagtgtt     2940

gtgagttgca gagacaggaa agatagaaga cgttccatgt gttattctga tggtcgaagt     3000

ttacatttgg aaaaaaatgg aaatcacaca ccatcctcca gtgtgggcag ctctgtagaa     3060

attagtttag aaaattctga actgtttaaa gatttgtctg atgccattga gcaaaccttt     3120

cagaggagaa atagtgaaac caaagtgcga cgtagcacga ggctacagaa ggatttagaa     3180

aacgaaggtc ttgtatggat ttcacttcca cttccttcca cttcccaaaa agccaaaaga     3240

agaacaatat gtacatttga cagcagtgga tttgaaagta tgtctcccat aaaagaaact     3300

gtgtcctcca gacaaaaacc gcagatggca cctcccgtct cagatccaga aaacagccag     3360

ggccctgctg ctggttcttc cgatgaacct ggtaagagga ggaagagctt ttgtatatct     3420

acacttgcaa atactaaagc cacttcccag ttcaaaggct accggagaag atcctctctt     3480

aatgggaagg gagagagctc tctgactgcc ttggaaagga ttgaacataa tggagaaaga     3540

aagcagtaat tgacatttcc tgcagagtct gtggcaagag ggaaagtaac catctatgct     3600

gaaatgatct gtctagttcc cattctctgt tcaacctcag tgtttcaaaa gttcctaata     3660

aataaactca tttgagttga acctactttt atgtagaaat aaataagttt cttcatcatt     3720

cagatagaaa a                                                          3731


<210> 1022
<211> 1706
<212> DNA
<213> Homo sapiens

<400> 1022
cccgtggacg ccgccgaaga agcatcgtta aagtctctct tcaccctgcc gtcatgtcta       60

agtcagagtc tcctaaagag cccgaacagc tgaggaagct cttcattgga gggttgagct      120

ttgaaacaac tgatgagagc ctgaggagcc attttgagca atggggaacg ctcacggact      180

gtgtggtaat gagagatcca aacaccaagc gctccagggg ctttgggttt gtcacatatg      240

ccactgtgga ggaggtggat gcagctatga atgcaaggcc acacaaggtg gatggaagag      300

ttgtggaacc aaagagagct gtctccagag aagattctca aagaccaggt gcccacttaa      360

ctgtgaaaaa gatatttgtt ggtggcatta aagaagacac tgaagaacat cacctaagag      420

attattttga acagtatgga aaaattgaag tgattgaaat catgactgac cgaggcagtg      480

gcaagaaaag gggctttgcc tttgtaacct ttgacgacca tgactccgtg gataagattg      540

tcattcagaa ataccatact gtgaatggcc acaactgtga agttagaaaa gccctgtcaa      600

agcaagagat ggctagtgct tcatccagcc aaagaggtcg aagtggttct ggaaactttg      660

gtggtggtcg tggaggtggt ttcggtggga atgacaactt cggtcgtgga ggaaacttca      720

gtggtcgtgg tggctttggt ggcagccgtg gtggtggtgg atatggtggc agtggggatg      780

gctataatgg atttggtaat gatggtaaca attttggagg tggtggaagc tacaatgatt      840

ttgggaatta caacaatcag tcttcaaatt ttggacccat gaagggagga aattttggag      900

gcagaagctc tggcccctat ggcggtggag gccaatactt tgcaaaacca cgaaaccaag      960

gtggctatgg cggttccagc agcagcagta gctatggcag tggcagaaga ttttaattag     1020

gaaacaaagc ttagcaggag aggagagcca gagaagtgac agggaagcta caggttacaa     1080

cagatttgtg aactcagcca agcacagtgg tggcagggcc tagctgctac aaagaagaca     1140

tgttttagac aaatactcat gtgtatgggc aaaaaactcg aggactgtat ttgtgactaa     1200

ttgtataaca ggttatttta gtttctgttc tgtggaaagt gtaaagcatt ccaacaaagg     1260

gttttaatgt agattttttt ttttgcaccc catgctgttg attgctaaat gtaacagtct     1320

gatcgtgacg ctgaataaat gtcttttttt taatgtgctg tgtaaagtta gtctactctt     1380

aagccatctt ggtaaatttc cccaacagtg tgaagttaga attccttcag ggtgatgcca     1440

ggttctattt ggaatttata tacaacctgc ttgggtggag aagccattgt cttcggaaac     1500

cttggtgtag ttgaactgat agttactgtt gtgacctgaa gttcaccatt aaaagggatt     1560

acccaagcaa aatcatggaa tggttataaa agtgattgtt ggcacatcct atgcaatata     1620

tctaaattga ataatggtac cagataaaat tatagatggg aatgaagctt gtgtatccat     1680

tatcatgtgt aatcaataaa cgattt                                          1706


<210> 1023
<211> 2530
<212> DNA
<213> Homo sapiens

<400> 1023
gaagcgattg cgagccagcg cgcgcgcttc ggcgttcccg gcggtctgcg aagtttccgg       60

agcccgggtc ccgccgcggg ttcgcgcttg tgctcgcgct cgttcctgga gtcggcggcc      120

gctgcgcgcg ctcgttgccc aacccggtcc ccgcccccag acacgccggg ctctcggggc      180

accacagcca tgtgctcgtt agcgtcaggc gctaccggtt attcacatct gctgaagaaa      240

cattttcaca ctgtaagtct gagcatcagt ttaatattga cagcatggtt cataaacatg      300

gacttgaatt ttatggatac attaagctaa taaattttat tagacttaag aatcctacag      360

ttgagtacat gaattccata tacaacccag tgccttggga gaaagaagag tatttgaagc      420

cagtattaga agatgacctt ttacttcaat ttgatgtaga agatctttat gaaccggtgt      480

cagtaccctt ctcatacccc aatggactca gtgaaaatac atctgttgtt gaaaaattga      540

aacatatgga agccagggca ctgtctgctg aagccgcatt ggccagagca cgtgaggatc      600

tgcaaaaaat gaaacaattt gctcaggatt ttgtgatgca cacagatgtc agaacctgct      660

cgtcatctac tagtgtcatt gcggacctcc aggaggatga ggatggtgtt tatttcagct      720

catacgggca ttatgggata catgaagaaa tgctaaagga caaaatacga acagaaagct      780

accgagattt catataccaa aatccacata tcttcaaaga caaggtagtt ttggatgttg      840

ggtgtggaac tggaattctc tctatgtttg ctgctaaagc tggggcgaag aaggttcttg      900

gagttgatca atctgaaata ctttaccagg caatggatat tataagacta aataaacttg      960

aagatactat tacactaatt aaaggaaaga ttgaagaagt tcatcttcct gtagaaaaag     1020

tagatgttat catatctgag tggatgggct attttcttct gtttgagtct atgttagatt     1080

ctgtccttta tgcaaagaac aaatacttgg caaaaggagg ctcggtctac cctgacattt     1140

gcactatcag ccttgtagca gtgagtgatg tgaataaaca tgctgataga attgcttttt     1200

gggatgatgt ctatggcttc aagatgtcct gcatgaagaa agcagttatt ccagaagctg     1260

ttgtggaagt tttagatccg aagactctta tttcagaacc ttgtggtatt aagcatatag     1320

attgccatac gacgtctatc tcagatttgg aattttcatc agattttacc ctgaaaatca     1380

caaggacatc catgtgcacg gcaattgctg gctactttga tatatatttt gagaagaatt     1440

gccacaacag ggtcgtgttc tctacgggcc ctcagagcac caaaacacac tggaaacaaa     1500

cagtatttct actggaaaaa ccattttcag ttaaagcagg tgaagccttg aaaggaaagg     1560

tcacagttca caagagtaag aaagatccac gttctctcac cgtgaccctc acgttgaata     1620

attcaactca aacttatggt ctccagtgaa acagccataa aagcacacta ccttgtagtt     1680

tttaatgtgg gggtagagtg ggtcagcagg agggagctgg ttttatgtga gcagatggat     1740

ggatgatgga ccctttccta atgagcctcc tcaataagag agaagttctc attgtgggaa     1800

tctgacatag ttcagctgag gaagagaatc agctgatcct catggtctgc cacgtaatca     1860

ttttcttaga cgtttgctcc accagattta accaaatgta actcccacat tgagtttatc     1920

tatattgaaa atcatttaca ttggcctata tttggaagag agatagtctt ttgtttttaa     1980

taagtttctt actataaatt ttaaacaaat tggttagtta tttggatatt ttattaaact     2040

agtaacacag gtactacaca ttttattatg gactcctctg aggaggagtt tttaattgta     2100

tttgctagaa aatcaggatg taataaagat ttgtataaaa aaactaaaat atggaaaaga     2160

gcttcagcct tcatatacaa atcatatatg cagacagcct agttgattat ctagcatact     2220

tagggttctc attttgtagt ttcttccctc tttgtgacta ttccttagcc ttatagattt     2280

ctagtactgc ccaggaaatc taatttcaat acatttatcc taggtttcat gaaagttttt     2340

aaagattggg ataaatatgt acttatttac taacgtatta tctttttcaa accagattta     2400

tgtgcaaagg ttaaacatgt aactgttact aagcagtcta taaagttgtc atttacaatt     2460

actgattcaa tttgaaatgt agaataaaat tttaataaaa tgtatcaact tataaaatat     2520

tttaaaaata                                                            2530


<210> 1024
<211> 384
<212> DNA
<213> Homo sapiens

<400> 1024
ctcaaccaaa tcctccactc ttgaaaccat gtgctactac agcaactact atggtggtct       60

gcgttatggc tatggagtcc tgggcggtgg ctatggctgt ggctgtggtt atggccatgg      120

ctatggaggc ctgggctgtg gctatggccg tggctatggt ggctatggat atggctgctg      180

ccgcccatct tgctatggaa gatactggtc ctgtggcttc tactgagaaa tatctggcaa      240

ctcaacctcg tggtctcttc cacatggact tcctaaattt gccttcataa ttcttcatat      300

gagtaattca tttttctgtt gtaaaatgtc aacatcatcc ttaagtatct ggaagaaaaa      360

ataggtcaga tgctgcaagc ctca                                             384


<210> 1025
<211> 7734
<212> DNA
<213> Homo sapiens

<400> 1025
agtagaggtg accgaggcgg tggcggcgga ggcggcaccg attgctgtgt cggccccagt       60

gcggccgaag tcgcggtaga gcgtagcccc acgcccctcc cccgtccgcg ccctccctct      120

ttccctgggg atggagaagg cgacggttcc ggtggcggcg gcgacggctg cagaaggaga      180

agggagcccc ccggcggtgg cggctgtggc gggccccccc gcggcggcgg aggtcggcgg      240

cggcgttggc ggcagcagca gagctcgctc ggcctcgtct cctcgtggga tggtgcgagt      300

ctgcgacctg ctcctgaaga agaagccgcc gcagcagcag caccacaagg ccaagcgtaa      360

ccggacttgc cgacccccca gcagcagcga aagcagcagc gacagcgaca acagcggcgg      420

cggtggaggc ggcggtggag gcggaggtgg cggcggcggc accagcagta acaacagcga      480

ggaagaagag gacgacgacg acgaggaaga ggaggtttct gaggtggagt ctttcatttt      540

ggatcaggat gatttggaaa atccaatgct ggaaacagct tccaagttgc tcttatcagg      600

tactgctgat ggtgcagacc tcaggacagt agatccagaa acacaggcta gactggaagc      660

tttactagaa gctgcaggaa taggaaaatt gtccacggct gatggtaaag cctttgcaga      720

tcctgaagta cttcggaggt tgacatcgtc tgttagttgt gcgttggatg aagctgctgc      780

tgcacttacc cgtatgagag ctgaaagcac agcaaatgca gggcagtcgg acaaccgcag      840

tttggcagaa gcctgttcag aaggagatgt aaatgctgtg cgaaagttac tcattgaagg      900

gcgaagtgta aatgaacaca cagaggaagg ggagagcctc ctttgtttag cttgttctgc      960

tggatactat gagcttgcac aggttttgtt ggcaatgcat gcaaatgtgg aagatagggg     1020

aatcaaaggt gacattacac ctttaatggc tgctgctaat ggaggacatg tcaaaattgt     1080

gaagttgctg ctagctcata aagcagatgt taatgcacag tcttcaacag gcaatacagc     1140

acttacatat gcttgtgctg gaggctatgt agatgttgta aaggtgctct tggaatccgg     1200

tgctagtatt gaggaccata atgaaaatgg tcatacccct cttatggaag ctggaagtgc     1260

tggacatgtg gaagtagcca gattgctgct agaaaatggg gctggcatta atacgcattc     1320

taatgaattt aaagagagtg cccttacctt agcttgttac aaaggacact tagagatggt     1380

gcgatttctt ttggaagcag gcgcggatca agagcataaa acagatgaaa tgcacactgc     1440

tctgatggag gcttgcatgg atggccatgt tgaagtagct aggttacttc ttgacagcgg     1500

tgcccaagtg aacatgcctg ctgattcatt tgagtcacca ttaactttgg ctgcatgtgg     1560

tgggcatgtg gaacttgcgg ctttacttat tgaaagagga gctagcctgg aagaggtcaa     1620

tgatgaaggt tatacaccat tgatggaagc agctcgagaa ggacatgaag aaatggtggc     1680

attacttctt ggtcaaggag caaatatcaa tgcacagaca gaagaaactc aagaaactgc     1740

cttgactctg gcttgctgtg gaggctttct ggaagtggca gactttctaa ttaaggcagg     1800

agccgatata gaactagggt gttctacccc tttaatggaa gctgctcaag agggtcattt     1860

ggagttagtt aaatacttat tagctgcagg agctaacgtt catgcaacaa cagcaacagg     1920

ggatacagca ctaacatatg cctgtgaaaa tggtcatact gatgtagcag atgtcttact     1980

tcaggcaggc gcagatctgg aacatgaatc tgaaggtgga agaactcctt taatgaaagc     2040

tgcaagagct ggtcatgttt gtactgttca gttcttaatt agtaaaggag cgaatgtgaa     2100

tagaaccaca gctaataatg accatactgt actgtccctg gcttgtgcag ggggtcatct     2160

ggcagtggtg gaactacttt tggctcatgg ggcagatcct actcaccgtt tgaaagatgg     2220

ctcaactatg ttgatagaag cagcaaaagg tggccataca agtgttgttt gctatctctt     2280

ggattatcct aataacttgc tttcagcccc tccaccagat gtcactcagt taactccccc     2340

atcccacgat ttaaataggg ctcctcgtgt accagttcaa gcactgccca tggttgttcc     2400

acctcaggag cctgacaaac cacctgccaa tgttgccacc actcttccca tcaggaataa     2460

agcagtcagt ggaagagcat ctgcaatgtc aaacactcct acccacagta ttgctgcatc     2520

catttcccaa cctcagactc caactccaag tcctatcatc tctccttcag ccatgcttcc     2580

tatctaccct gccattgata ttgatgcaca gactgagagt aatcatgaca cggcactaac     2640

acttgcctgt gctggtggcc acgaggaact ggtacaaaca ctgctagaga gaggagctag     2700

tatagagcac cgagacaaga aaggttttac tccactcatc ttggctgcca cagctggtca     2760

tgttggtgtt gtggaaatat tgctggacaa tggtgcagac attgaagccc agtctgaaag     2820

aaccaaggac acaccactct ccttggcttg ttctggggga agacaggagg tggtggagct     2880

attgttagct cgaggggcaa ataaagagca caggaatgtt tctgattaca cacctctaag     2940

tctggctgct tctggtggct atgtgaacat catcaaaata ttactaaatg caggagctga     3000

gattaactct agaactggta gcaaattggg catctctcct ctgatgttag cagctatgaa     3060

tgggcataca gctgctgtta agctcctgtt agacatgggc tctgacataa atgctcagat     3120

agaaaccaat cggaacactg cccttacttt agcctgcttc caaggaagaa ctgaagtggt     3180

tagtcttctg cttgatagaa aagcaaatgt tgaacacaga gctaagactg gtctcacacc     3240

actaatggaa gctgcctctg gtggatatgc ggaggtgggc cgagttcttt tggataaagg     3300

tgctgatgtt aatgcccctc cagttccctc ctcaagagat acagctttaa ccatagcagc     3360

agataaaggg cattacaaat tctgtgagct tcttattggc aggggagctc atattgatgt     3420

acgtaacaag aaggggaaca ctccattgtg gctagcagca aatggtggac acctcgatgt     3480

ggttcagtta ctggtgcaag caggtgcaga tgtggatgca gcagataacc gcaagataac     3540

tcctcttatg gcagcattta gaaagggtca tgtgaaggtg gtgcgctact tagtcaaaga     3600

agtcaatcag tttccatcag attctgaatg tatgagatac atagcaacca tcactgataa     3660

ggagatgctg aagaagtgtc atctttgtat ggagtcaata gtacaagcca aagatagaca     3720

ggctgctgaa gcaaacaaaa acgccagcat tttgttagag gagttagact tggaaaagtt     3780

aagggaagaa agtcggaggc tggctttggc tgcgaaaaga gaaaaaagaa aagagaagag     3840

aaggaagaaa aaggaagaac aaagaaggaa actagaagaa attgaagcca aaaataaaga     3900

gaactttgaa ctccaagctg ctcaagaaaa agaaaagctt aaagttgaag atgagcctga     3960

agtcttgaca gaacctccaa gtgccacaac cactactacc ataggtatat ctgcaacctg     4020

gacaactttg gcaggttctc atggtaaaag aaataatacc ataactacaa ccagttcaaa     4080

gaggaaaaac aggaaaaata aaattactcc agaaaacgtt caaattatat ttgatgatcc     4140

actaccaatt tcatacagtc agccagagaa ggtgaatgga gagtccaaga gcagcagtac     4200

cagcgagagt ggggacagtg ataacatgag gatttccagc tgcagcgatg aaagtagtaa     4260

cagcaacagc agtcgtaaga gtgacaatca ttcaccagct gtggtcacta ccactgtgag     4320

cagcaaaaag cagccatcag ttcttgttac atttccaaag gaagagagaa aatctgtttc     4380

tggcaaggct tcaataaaat tgtcagaaac tatcagtgaa gggaccagta attctctatc     4440

tacttgtaca aaatctggtc catctcccct ttcttctcca aatgggaagt taacagtagc     4500

aagtcctaag cgtgggcaaa agagggaaga aggatggaaa gaagttgtaa gaaggtcaaa     4560

gaaagtatct gttccatcaa ctgtgatatc cagagtgatt ggaagaggag gctgtaatat     4620

caatgctatt cgggagttta ctggtgcaca catagatatt gataaacaga aagacaagac     4680

tggagaccgg ataatcacta taaggggtgg cactgaatca acaagacaag caactcaatt     4740

gattaatgct ttgatcaagg atccagacaa agaaattgat gaacttattc caaagaatcg     4800

tttgaaaagc tcctcagcaa attccaaaat agggtcatca gcacctacca ccactgctgc     4860

taacacttcc ttaatgggaa ttaaaatgac aactgtagct ctgtcatcaa catctcaaac     4920

tgccacagca ctcactgtgc ctgcaatttc ttctgcatcc actcacaaaa ccattaagaa     4980

cccagtgaat aatgtgaggc ctggttttcc agtttctctt ccattagcat atcctcctcc     5040

acagtttgca catgctttgc ttgctgctca gactttccag cagatccgtc caccaaggtt     5100

gcccatgacc cactttggag gtacttttcc accagctcaa tccacttggg gtccgtttcc     5160

tgtcaggcct ttgagccctg ccagagctac taactcgcct aagcctcaca tggtgcctcg     5220

ccatagcaat cagaatagca gtggttctca ggtgaattca gcaggttctt taacttcaag     5280

cccaacaact acaaccagtt catcagcttc aacggtgcct ggtacatcta caaatggcag     5340

tccaagttca ccttctgtcc gaaggcagct ttttgtcaca gttgtgaaga catccaatgc     5400

caccacaaca acagtcacaa ccacggcaag caacaacaac actgcaccca caaatgccac     5460

atatcctatg cctactgcca aagaacacta tccagtatca tccccatctt ccccatcacc     5520

accagcccag ccaggagggg tttctagaaa cagccctttg gattgtggat cagcatctcc     5580

aaataaagtg gcatcttcct ccgaacagga agcaggtagt ccaccagtag tagaaacaac     5640

aaacactaga cctccaaaca gcagcagttc ttctgggagt tcatcagctc attctaatca     5700

gcaacaacct ccgggatctg tttctcagga accaagacca cctcttcagc agtctcaggt     5760

tcctcccccg gaagttagaa tgactgttcc tcctttagca acaagttctg ctccagtggc     5820

ggtgccttct actgccccag tgacttaccc tatgcctcag acaccaatgg gatgccccca     5880

gcctactcct aaaatggaaa cccctgctat tagaccaccc cctcatggca caactgcccc     5940

tcacaagaat tcagcttcag tgcaaaattc atctgttgca gtcctcagtg tcaatcacat     6000

taaaagacct cacagtgttc cctcttctgt ccagctacct tcgaccttaa gtacacaaag     6060

tgcttgtcag aattcagtac atccagcaaa taagcctatt gctcccaatt tcagtgcccc     6120

cttaccattt gggcccttta gcacattgtt tgaaaacagc cctacttctg ctcatgcctt     6180

ctggggagga tctgttgttt catctcagtc aacaccagaa tctatgctat caggaaaatc     6240

ctcatatttg ccaaattcag atcctttaca tcagtctgat acttccaaag ctccaggttt     6300

tagaccacca ttacagagac ctgctccaag tccctcaggt attgtcaata tggactcgcc     6360

atatggttct gtaacacctt cttcaacaca tttgggaaac tttgcttcaa acatttcagg     6420

aggtcagatg tacggacctg gggcacccct tggaggagca cccgcagctg ctaactttaa     6480

cagacaacat ttttccccgc ttagtttgtt gactccgtgt tcatcagcat caaatgattc     6540

ttctgcacag tcagtatcct cgggagttcg tgcaccatct cctgccccat catcagtacc     6600

gttagggtca gaaaagccca gcaatgtgtc tcaggacagg aaagttccag tccctattgg     6660

gactgaacgt tctgcacgta tcaggcaaac tggaacgtca gctccatctg ttattgggag     6720

caatttgtct acatcagtag gacatagtgg catctggtcc tttgaaggga ttggtggcaa     6780

tcaagacaaa gtagactggt gtaaccctgg gatgggaaat cctatgatcc acagaccgat     6840

gtctgaccca ggagtatttt cacaacatca agcaatggag cgagatagta caggaattgt     6900

aactccttct ggtacattcc atcagcatgt tcctgcaggc tacatggact ttcctaaagt     6960

tgggggtatg cctttttctg tgtatgggaa tgcaatgatt cctccagtag cacctatccc     7020

tgatggtgct ggaggaccca tatttaatgg ccctcatgct gcagaccctt cttggaactc     7080

actgataaag atggtttcca gctccacgga aaataatggc cctcaaacgg tgtggactgg     7140

accctgggca cctcacatga acagtgtgca tatgaaccag cttggctgat gaggatcagc     7200

ttgttagcct gcagattcct tttcatttgg aggaaatcac aagtggccga aaaaaaaaat     7260

tatgctccca aatcattcta ctgatgtgct tgactgaagt gtgtaggctt tttgcagaag     7320

atcttactaa ctgacctatt ttctgtgaac atttgtgact gcccattccc catcatcatc     7380

cgttttacct tagttagcat ttttcttatc atttttcttt ttttctttcc ctcttcccct     7440

ttggacataa ctttctgttg aagctgttct ttggctggtt ggttttagta ctgtaaactg     7500

cttctgagca aacacggaaa tttagcaaaa ttatgtaaac ttgatcctga agttttagaa     7560

tggcaaataa atgtacaatt gtttacataa cagaaaaggc taagcagaaa gtaaatttca     7620

atatgtcagt atagaggctc tactttatgt agacttaaat taatgtgaga tatgtacctt     7680

catattcaga aatctggatg tttccttcat acattaaact attaataagc ataa           7734


<210> 1026
<211> 1766
<212> DNA
<213> Homo sapiens

<400> 1026
ccccggcccg gctccattta atggcgcgga cgccggcggc ggcgggctcc tggccgggcc       60

agcgcagcgg aagagccaag ccagcatgtc ggggacccga gcctccaacg accggccccc      120

cggcgcaggc ggcgtcaagc gggggcggct gcagcaggag gcggcggcga ccggctcccg      180

cgtgacggtg gtgctgggcg cgcagtgggg ggacgagggc aaaggcaagg tggtggacct      240

gctggccacg gacgccgaca tcatcagccg ctgccagggg ggcaacaacg ccggccacac      300

ggtggtggtg gatgggaaag agtacgactt ccacctgctg cccagcggca tcatcaacac      360

caaggccgtg tccttcattg gcaacggggt ggtcatccac ttgccaggct tgtttgagga      420

agcagagaag aatgaaaaga aaggcctgaa ggactgggag aagaggctca tcatctctga      480

cagagcccac cttgtgtttg attttcacca ggctgtcgac ggacttcagg aagtgcagcg      540

ccaggcacaa gaggggaaga atataggcac caccaagaag ggaatcggac caacctactc      600

ttccaaagct gcccggacag gcctccgcat ctgcgacctc ctgtcagatt ttgatgagtt      660

ttcctccaga ttcaagaacc tggcccacca gcaccagtcg atgttcccca ccctggaaat      720

agacattgaa ggccaactca aaaggctcaa gggctttgct gagcggatca gacccatggt      780

ccgagatggt gtttacttta tgtatgaggc actccacggc ccccccaaga agatcctggt      840

ggagggtgcc aacgccgccc tcctcgacat tgacttcggg acctacccct ttgtgacttc      900

atccaactgc accgtgggcg gtgtgtgcac gggcctgggc atccccccgc agaacatagg      960

tgacgtgtat ggcgtggtga aagcctatac cacacgtgtg ggcatcgggg ccttccccac     1020

cgagcagatc aacgagattg gaggcctgct gcagacccgc ggccacgagt ggggagtgac     1080

cacaggcagg aagaggcgct gcggctggct cgacctgatg attctaagat atgctcacat     1140

ggtcaacgga ttcactgcgc tggccctgac gaagctggac atcctggacg tactgggtga     1200

ggttaaagtc ggtgtctcat acaagctgaa cgggaaaagg attccctatt tcccagctaa     1260

ccaggagatg cttcagaagg tcgaagttga gtatgaaacg ctgcctgggt ggaaagcaga     1320

caccacaggc gccaggaggt gggaggacct gcccccacag gcccagaact acatccgctt     1380

tgtggagaat cacgtgggag tcgcagtcaa atgggttggt gttggcaagt caagagagtc     1440

gatgatccag ctgttttagt cacagactga gctgatccca acaggccctg gcagcgtctg     1500

gacttgtgta aacagcagca gtcacgttcc tcggccgcca caaccaacac caaagcagga     1560

aaaccatttt ctgtactttt atatttctgt tcaacctgtt ggtttctaca atgattttaa     1620

acattggaaa gccagccttg tgtatatttt taaaaattat attcaaaatg agccaaagtg     1680

ctcagagacc ttctatgaca cattagtgtc acatggttgc gtgtccagcc gaagcagtgt     1740

aataaacatc tccaatggcc actgaa                                          1766


<210> 1027
<211> 2653
<212> DNA
<213> Homo sapiens

<400> 1027
acgtgacccg cacggcgcct cgaggccgga agcgattgcg agccagcgcg cgcgcttcgg       60

cgttcccggc ggtctgcgaa gtttccggag cccgggtccc gccgcgggtt cgcgcttgtg      120

ctcgcgctcg ttcctggagt cggcggccgc tgcgcgcgct cgttgcccaa cccggtcccc      180

gcccccagac acgccgggct ctcggggcac cacagccatg tgctcgttag cgtcaggcgc      240

taccggcggc cggggcgctg tggagaatga ggaggacctg ccagaactgt cggacagcgg      300

ggacgaggcc gcctgggagg atgaggacga tgcagatctc ccccacggca agcagcagac      360

cccctgcctg ttctgtaaca ggttattcac atctgctgaa gaaacatttt cacactgtaa      420

gtctgagcat cagtttaata ttgacagcat ggttcataaa catggacttg aattttatgg      480

atacattaag ctaataaatt ttattagact taagaatcct acagttgagt acatgaattc      540

catatacaac ccagtgcctt gggagaaaga agagtatttg aagccagtat tagaagatga      600

ccttttactt caatttgatg tagaagatct ttatgaaccg gtgtcagtac ccttctcata      660

ccccaatgga ctcagtgaaa atacatctgt tgttgaaaaa ttgaaacata tggaagccag      720

ggcactgtct gctgaagccg cattggccag agcacgtgag gatctgcaaa aaatgaaaca      780

atttgctcag gattttgtga tgcacacaga tgtcagaacc tgctcgtcat ctactagtgt      840

cattgcggac ctccaggagg atgaggatgg tgtttatttc agctcatacg ggcattatgg      900

gatacatgaa gaaatgctaa aggacaaaat acgaacagaa agctaccgag atttcatata      960

ccaaaatcca catatcttca aagacaaggt agttttggat gttgggtgtg gaactggaat     1020

tctctctatg tttgctgcta aagctggggc gaagaaggtt cttggagttg atcaatctga     1080

aatactttac caggcaatgg atattataag actaaataaa cttgaagata ctattacact     1140

aattaaagga aagattgaag aagttcatct tcctgtagaa aaagtagatg ttatcatatc     1200

tgagtggatg ggctattttc ttctgtttga gtctatgtta gattctgtcc tttatgcaaa     1260

gaacaaatac ttggcaaaag gaggctcggt ctaccctgac atttgcacta tcagccttgt     1320

agcagtgagt gatgtgaata aacatgctga tagaattgct ttttgggatg atgtctatgg     1380

cttcaagatg tcctgcatga agaaagcagt tattccagaa gctgttgtgg aagttttaga     1440

tccgaagact cttatttcag aaccttgtgg tattaagcat atagattgcc atacgacgtc     1500

tatctcagat ttggaatttt catcagattt taccctgaaa atcacaagga catccatgtg     1560

cacggcaatt gctggctact ttgatatata ttttgagaag aattgccaca acagggtcgt     1620

gttctctacg ggccctcaga gcaccaaaac acactggaaa caaacagtat ttctactgga     1680

aaaaccattt tcagttaaag caggtgaagc cttgaaagga aaggtcacag ttcacaagag     1740

taagaaagat ccacgttctc tcaccgtgac cctcacgttg aataattcaa ctcaaactta     1800

tggtctccag tgaaacagcc ataaaagcac actaccttgt agtttttaat gtgggggtag     1860

agtgggtcag caggagggag ctggttttat gtgagcagat ggatggatga tggacccttt     1920

cctaatgagc ctcctcaata agagagaagt tctcattgtg ggaatctgac atagttcagc     1980

tgaggaagag aatcagctga tcctcatggt ctgccacgta atcattttct tagacgtttg     2040

ctccaccaga tttaaccaaa tgtaactccc acattgagtt tatctatatt gaaaatcatt     2100

tacattggcc tatatttgga agagagatag tcttttgttt ttaataagtt tcttactata     2160

aattttaaac aaattggtta gttatttgga tattttatta aactagtaac acaggtacta     2220

cacattttat tatggactcc tctgaggagg agtttttaat tgtatttgct agaaaatcag     2280

gatgtaataa agatttgtat aaaaaaacta aaatatggaa aagagcttca gccttcatat     2340

acaaatcata tatgcagaca gcctagttga ttatctagca tacttagggt tctcattttg     2400

tagtttcttc cctctttgtg actattcctt agccttatag atttctagta ctgcccagga     2460

aatctaattt caatacattt atcctaggtt tcatgaaagt ttttaaagat tgggataaat     2520

atgtacttat ttactaacgt attatctttt tcaaaccaga tttatgtgca aaggttaaac     2580

atgtaactgt tactaagcag tctataaagt tgtcatttac aattactgat tcaatttgaa     2640

atgtagaata aaa                                                        2653


<210> 1028
<211> 1920
<212> DNA
<213> Homo sapiens

<400> 1028
ccctttcctt tatcatgtgt ctgtattgtg taccctcctt catttccgaa attcaaacaa       60

acaaaaaaag ccagcgtcta aaaggccaga tggccgatag cggacccctc ctcctgcccc      120

caatttcaag cttaaagtag ccagcgtgga ttctgatttc aaaatagaag atgagttgtc      180

acactccctg gaccatttct tcagcacaac acagttttag ggggagcctc aggatatacg      240

tgcacatgtc cttgggccag gatgtccgta ctaagccctg gggatctaaa accaaagcga      300

ggctccccac acagaggcag ccttgaccgc acagatgcct ccaccgatct ggccatgagg      360

tcctggccct cggagctggg ctcccggact tgctcaactt cagccaccac tacagcccct      420

tccaactcca cccccatcgc ccggcaccca ggccgcacca aaggctataa ctcagatgac      480

aacctctgtg agccatccct ggagtttgag gtccccaacc acaggcagta cgtgtcgcgg      540

ccaagtagct tagagagcag tagaaacaca tccagcaaca gctcacctct taacctaaaa      600

ggctcctccg agcagctcca tggccggtct gagagcttca gcagcgaaga cctgatcccc      660

agcagggacc tggccacttt gccccgggaa gccagcacac cgggacgcaa cgccctcggc      720

cgccacgagt accccttgcc tcggaacggg cctctcccac aggagggtgc ccagaagagg      780

ggcacagccc ctccctacgt cggagtgcgg ccctgctcgg cctcccccag cagtgagatg      840

gtcaccttgg aggagttcct ggaggagagc aaccgcagct cccccaccca tgacactccc      900

agttgccggg atgacctgct gagtgactac ttccgaaagg ccagcgatcc cccagccatc      960

ggaggccaac caggaccacc tgccaagaaa gaaggggcca agatgcccac caactttgtg     1020

gcccccaccg tcaaaatggc cgcccccacc tcggagggga ggccgctgaa gcccgggcag     1080

tacgtaaagc caaacttcag actgactgag gccgaggccc cacccagcgt ggccccgaga     1140

caggcccagc ctccccagag cctgtctctg ggcagacccc ggcaggctcc ggtgccccca     1200

gcttcccatg cacctgccag ccgcagtgcc tccttgagcc gggccttcag cctggcctca     1260

gctgaccttc tccgggccag cgggccagag gcctgcaaac aggagtcccc tcagaagctg     1320

ggggctcctg aggccttagg gggcagagag acaggcagcc acaccctgca aagccccgca     1380

ccccccagct cccatagcct ggcccgggag cggaccccac ttgtgggaaa ggctggcagc     1440

tcctgtcagg gcccaggtcc ccgcagccgg ccgctggaca cgaggcgctt ctccctggct     1500

cccccaaagg aggagaggct ggcccccctg catcagtctg ccacagcccc cgccattgcc     1560

actgcaggtg ctggtgctgc tgctgctggc agtggcagca actcccagct cctgcacttc     1620

tcacctgctg cagccccggc tgccaggacc aagcccaagg cgcccccacg ctcaggggag     1680

gtggccacca tcacccctgt ccgggcaggg ctcagcctct cagagggaga cggggtcccg     1740

gggcagggct gcagtgaggg gcttccggcc aagagcccag gtcggtctcc cgatttggct     1800

ccccacctcg gccgggccct ggaggactgc agtcgaggga gcgtctcaaa gagcagtccg     1860

gcctccccgg agcccggcgg ggatccgcag accgtgtggt atgagtacgg ctgtgtgtga     1920


<210> 1029
<211> 1095
<212> DNA
<213> Homo sapiens

<400> 1029
gagccgatgc ccgattccgc gcccgccatg gccgacaaaa tggacatgtc tctggacgac       60

atcattaaac tgaaccggag ccagcgaggc ggccggggcg ggggccgggg ccgcggccgg      120

gccggctccc agggcggccg cggcggtggg gcgcaggccg ccgcgcgagt gaatcgaggc      180

ggcgggccca tccggaaccg gccggccatc gcccgcggcg cggccggcgg aggcggcagg      240

aaccgaccgg cgccctacag caggccaaaa caacttcccg acaagtggca gcacgatctt      300

ttcgacagtg gcttcggcgg tggtgccggc gtggagacag gtgggaaact gctggtgtcc      360

aatctggatt ttggagtctc agacgccgat attcaggaac tctttgctga atttggaacg      420

ctgaagaagg cggctgtgca ctatgatcgc tctggtcgca gcttaggaac agcagacgtg      480

cactttgagc ggaaggcaga tgccctgaag gccatgaagc agtacaacgg cgtccctctg      540

gatggccgcc ccatgaacat tcagcttgtc acgtcacaga ttgacgcaca gcggaggcct      600

gcacagagcg taaacagagg tggcatgact agaaaccgtg gcgctggagg ttttggtggt      660

ggtggaggca cccggagagg cacccgcgga ggcgcccgtg gaagaggcag aggtgccggc      720

aggaattcaa agcagcagct ttcggcagag gagctggatg cccagctgga cgcctataat      780

gcgagaatgg acaccagtta aacagaccag caaatccgcg tgcggaacag gacccaggcg      840

tctcctcttg ctccctggtt ggggggcggt ggctggggct gtgcggccaa tgatggattt      900

gtttctttta tgttttaaaa taggatttaa aaactcatgt aaaggttttt tttttttctt      960

tttttttttt tttaattctg aaacagacct gttttgtacc gagttatttt tgggataaat     1020

tttactggtt gctgttgtgg agaaggtggc gtttccacct tttccataat aaaatagaaa     1080

tgtgtgtaga actgg                                                      1095


<210> 1030
<211> 876
<212> DNA
<213> Homo sapiens

<400> 1030
atgggagtgg cggcgcggcc cccagccctg cggcactggt tcagccactc aattcctctc       60

gctatcttcg cgctgctgct gctttatctc agtgttcgga gcctaggcgc ccgctcgggc      120

tgcggaccca gggcgcagcc ctgcgttcca ggggaaacgg cgcccttcca ggtccggcag      180

gagtcgggaa ccctggaggc cccggagagg aaacagcctc cgtgtctggg ccctcggggg      240

atgctgggcc gcatgatgag gcggttccac gccagtctga aacccgaagg ggatgtgggg      300

ctgtcgccgt acctggcggg atggagggca ctcgtcgagt tcctgactcc cctcggctcc      360

gtcttcgcct tcgccactag ggaggccttc accaaggtga cagacctgga ggctcgggtg      420

cacggcccgg acgcggagca ctactggtcg ctggtggcca tggcggcgtg ggagcggagg      480

gcgggactgc tggagcagcc gggggcggcc ccccgggacc cgacccggag ctcgggctct      540

cgcacgctgc tcctgctgca ccgcgcgctg cgctggtccc agctctgcct ccaccgggtg      600

gcgaccggcg cgctgggagg cccggacgcg ggcgtgcagt gcagcgacgc ctaccgtgcg      660

gccctgggtc cgcatcaccc ctggctggtc cgacagaccg cccgcctcgc cttcctcgcc      720

ttcccgggtc gccgccgcct gctggagctg gcgtgtcccg gagccaccga ggcggaggcg      780

cgggccgcgc tggtccgggc cgccggcacc ttggaggatg tctacaaccg cacccagagc      840

ctgctggccg agcgcggcct gctccagctg gcctaa                                876


<210> 1031
<211> 3959
<212> DNA
<213> Homo sapiens

<400> 1031
cggacggggc cgccccgatg ggacgccgcg ctccggcccc tgcgcgccgc tgagccgagc       60

gccccccgct gccgagaccc ccgccgccac cgccagccgc tgccccctcg cccccgcccg      120

ggccgggagc ctcgtccccg tcccccggaa agctggattt ccgaggctgg aggcgcctgg      180

ccggctgggt ggggaccacc atgggcaacg cggccggcag cgccgagcag cccgcgggcc      240

ccgccgcgcc gccccccaag cagcccgcgc ctcccaagca gccgatgccc gcggccggag      300

agctggagga gaggttcaac cgcgccctga actgcatgaa cttgccccca gacaaggtcc      360

agctgctgag ccagtatgac aacgagaaga agtgggagct catctgtgat caggagcggt      420

ttcaagtcaa gaatcccccc gcagcctaca tccagaagct gaagagctat gtggatactg      480

gtggggtcag ccgaaaggta gcagctgatt ggatgtccaa cctggggttt aagaggcgag      540

ttcaggagtc cacgcaggtg ctacgggagc tggagacctc cctgaggacc aaccacattg      600

ggtgggtgca ggagttcctc aatgaagaga accgtggcct ggatgtgctg ctcgagtacc      660

tggcctttgc ccagtgctct gtcacgtatg acatggagag cacagacaac ggggcttcca      720

actcagagaa aaacaagccc ctggagcagt ctgtggaaga cctcagcaag ggtccaccct      780

cctccgtgcc caaaagccgc cacctgacca tcaagctgac cccagcccac agcaggaagg      840

ccctgcggaa ttcccgcatc gtcagccaga aggacgacgt ccacgtctgt attatgtgcc      900

tacgcgccat catgaactac cagtctggct tcagccttgt catgaaccac ccagcctgtg      960

tcaatgagat tgctctgagc ctcaacaaca agaaccccag aaccaaggct ctggtgctgg     1020

agctgctggc ggccgtgtgc ttggtgcggg gaggacatga catcatcctt gcagcctttg     1080

acaacttcaa ggaggtgtgt ggggagcagc accgctttga aaagctgatg gaatatttcc     1140

ggaatgagga cagcaacatc gacttcatgg tggcctgcat gcagttcatc aacattgtgg     1200

tacattcggt ggagaacatg aacttccgtg tcttcctgca atatgagttc acccacttgg     1260

gcctggacct gtacttggag aggcttcggc tcaccgagag tgacaagctg caggtgcaga     1320

tccaggcgta cctggacaat atttttgatg tgggggcgct gctggaggac acagagacca     1380

agaacgctgt gctggagcac atggaggaac tgcaggagca agtggcgctg ctgacagagc     1440

ggcttcggga cgcggagaac gaatccatgg ccaagattgc agaactggaa aaacagctaa     1500

gccaggcgcg caaggagttg gagaccctgc gggagcgctt cagcgaatcg accgccatgg     1560

ggccctccag gcgtccccca gagcctgaga aagcgcctcc cgctgccccg acgcggccct     1620

cggccctgga gctgaaggtg gaggagctgg aggagaaggg gttaatccgt attctgcggg     1680

ggccggggga tgctgtctcc atcgagatcc tccccgtcgc tgtggcaact ccgagcggcg     1740

gtgatgctcc gactccgggg gtgccgaccg gctcccccag cccagatctc gcacctgcag     1800

cagagccggc tcccggagca gcgccaccgc cgccgccccc actgcccggc ctcccctccc     1860

cgcaggaagc cccgccctct gcgcccccac aggccccgcc tctccctggc agcccggagc     1920

ccccgcctgc gccgccgctg cccggagacc tgccgccccc acccccgcca ccgccaccac     1980

ctccgggcac tgacgggccg gtgcctccgc cgccgccgcc gccgccgccg cctcccggag     2040

gtcctcctga tgccctagga agacgcgact cagaattggg cccaggagtg aaggccaaga     2100

agcccatcca gactaagttc cgaatgccac tcttgaactg ggtggcactg aaacccagcc     2160

agatcaccgg cactgtcttc acagagctca atgatgagaa ggtgctgcag gagctagaca     2220

tgagtgattt tgaggaacag ttcaagacca agtcccaagg ccccagcctg gacctcagcg     2280

ctctcaagag taaggcagcc cagaaggccc ccagcaaggc gacactcatt gaggccaacc     2340

gggccaagaa cttggccatc accctgcgga agggcaacct gggggccgag cgcatctgcc     2400

aagccattga ggcgtacgac ctgcaggctc tgggcctgga cttcctggag ctgctgatgc     2460

gcttcctgcc cacagagtat gagcgcagcc tcatcacccg ctttgagcgg gagcagcggc     2520

caatggagga gctgtcagag gaggaccgct tcatgctatg cttcagccgc atcccgcgcc     2580

tgccggagcg catgaccaca ctcaccttcc tgggcaactt cccggacaca gcccagctgc     2640

tcatgccgca actgaatgcc atcattgcag cctcaatgtc catcaagtcc tctgacaaac     2700

tccgccagat cctggagatt gtcctggcct ttggcaacta catgaacagt agcaagcgtg     2760

gggcagccta tggcttccgg ctccagagcc tggatgcgct gttggagatg aagtcgactg     2820

atcgcaagca gacgctgctg cactacctgg tgaaggtcat tgctgagaag tacccgcaac     2880

tcacaggctt ccacagcgac ctgcacttcc tggacaaggc gggctcagtg tccctggaca     2940

gtgtcctggc ggacgtgcgc tccctgcagc gaggcctaga gttgacacag agagagtttg     3000

tgcggcagga tgactgcatg gtgctcaagg agttcctgag ggccaactcg cccaccatgg     3060

acaagctgct ggcagacagc aagacggctc aggaggcctt tgagtctgtg gtggagtact     3120

tcggagagaa ccccaagacc acatccccag gcctgttctt ctccctcttt agccgcttca     3180

ttaaggccta caagaaagct gagcaggagg tggaacagtg gaaaaaagaa gccgctgccc     3240

aggaggcagg cgctgatacc ccgggcaaag gggagccccc agcacccaag tcaccgccaa     3300

aggcccggcg gccacagatg gacctcatct ctgagctgaa acggaggcag cagaaggagc     3360

cactcattta tgagagcgac cgtgatgggg ccattgaaga catcatcaca gtgatcaaga     3420

cggtgccctt cacggcccgc accggcaagc ggacatcccg gctcctctgt gaggccagcc     3480

tgggagaaga gatgcccctc tagcccctca gatctgcgga accagcccta catccgcgca     3540

gacacaggcc gccgcagtgc ccgtcggcgt cccccgggcc ccccactgca ggtcacctcc     3600

gacctctcgc tgtagccgct atttctgcag gtggattctg caggggtgtg gggccgtgga     3660

caggctgagg ctcaaggaag gtggtcctca gctcggctgg ccgggcagcc cctcctccgc     3720

tgtggcccgc ctcaaacggg ctggtgcatc ctcctcttgg ccacagaggg cagcatcgcc     3780

cgccccttcc cccaaatgct gcttgcagca cccaccctaa agccccctcc aaatagccat     3840

acttagcctc agcaggagcc tggcctgtaa cttataaagt gcacctcgcc cccgcaagcc     3900

ccagccccga ggaccgtcca tggaccttat ttttatatga gattaataaa gatgtttgc      3959


<210> 1032
<211> 3175
<212> DNA
<213> Homo sapiens

<400> 1032
gggagcgagc cggtgctgct gcaggctgag gctgcggcag aggcggcgag gcgcgggcgg       60

tgaggacgga cagtcaccga cttagtccag ttccctgtga tctcaaaaca attgttgcag      120

caggctcctg gcagtctcaa gcagttcatc ttcttggtgt actggtttcc tattgtgatt      180

ttatcatgga aaatcaattg gctaaatcaa ctgaagaacg aacatttcag taccaggatt      240

ctcttccatc actgcctgtt ccttcacttg aagaatcatt aaaaaaatac cttgaatcag      300

tgaaaccatt tgcaaatcaa gaagaatata agaaaactga agaaatagtt caaaaatttc      360

aaagtgggat tggagaaaaa ttgcaccaga aattgcttga aagagcaaaa ggaaaaagaa      420

attggctgga agagtggtgg ctgaatgttg cctatctgga tgttcgtata ccatcacaat      480

tgaatgtcaa ctttgcgggt cctgcagctc attttgaaca ctactggcct ccaaaggaag      540

ggactcaatt agaaagagga agtataactc tttggcataa cttgaactac tggcagctat      600

taagaaaaga aaaagtgcct gttcataaag ttggaaatac tcctctagat atgaatcaat      660

tccgaatgct attttctacc tgcaaggttc caggaattac tagagactcc attatgaatt      720

attttaggac tgagagtgaa gggcgttccc caaaccacat tgtagtgctg tgtcgaggcc      780

gagcttttgt ctttgatgta atacatgaag gatgtttggt caccccgcca gagcttctca      840

gacaactgac atatatccac aagaagtgcc atagtgaacc tgatggacct gggattgcag      900

cattaactag tgaggagcga actcgatggg ctaaggcacg agaatatctg attggtcttg      960

atccagagaa cttggctttg ttagaaaaaa ttcagagtag tttactggta tattccatgg     1020

aggatagcag tccacatgta acaccagagg attattctga gattattgca gccatcctta     1080

ttggagatcc aacagtacgc tggggtgaca aatcctataa cttgatttcc ttttctaatg     1140

gagtatttgg ctgtaattgt gatcatgctc cttttgatgc aatgattatg gtgaacatca     1200

gttattatgt ggatgagaaa atttttcaga atgaaggaag atggaagggt tcagagaagg     1260

tacgagatat accacttcca gaagagctca ttttcattgt ggatgagaaa gttttaaatg     1320

acatcaacca agctaaagcc cagtatctca gggaggcatc tgatctacag attgcggctt     1380

atgcctttac atcttttggc aaaaagctaa ccaagaacaa gatgcttcac ccggatacgt     1440

ttattcagct tgcacttcag ctggcctatt acagacttca tggacaccct ggttgttgct     1500

atgaaacagc tatgacaaga catttttatc atggccgtac agagactatg cgatcatgca     1560

cagttgaagc agtgaggtgg tgccagtcca tgcaggatcc ttctgtcaat cttcgtgagc     1620

ggcagcaaaa gatgttacaa gcttttgcaa agcataataa aatgatgaaa gattgttcag     1680

ctggaaaagg atttgatcgt caccttttag gtctcttact catagcaaaa gaggaaggtc     1740

ttcctgttcc agaactcttt acggacccac ttttttccaa aagcggagga ggtggaaatt     1800

ttgttctctc aacaagtctg gttggctatt tacgagtcca gggagtggta gttcccatgg     1860

tacacaatgg ttatggattt ttctaccata tcagagatga caggtttgtt gtggcctgtt     1920

cagcctggaa atcctgtccc gagactgatg cggaaaagct agttcagctg actttttgtg     1980

cttttcatga tatgatacag ctgatgaact ctactcatct ttagagatga atcatctatt     2040

aagcacttac caaaacatat cattaaactg agtgctggga gtgagttggt aatatgagat     2100

gggaaggaat gttgacttgc taacattcct ttaacaagtt aagaaaactt gttaaatgta     2160

gaaattagta gaatcatgct ctctaaattt attctgccat agaaggtaga aatattttta     2220

agctcctctg atgcagcagc aatgcaaatt atgacatagt gaatatagaa ctatgcagta     2280

tttaagcctc aacaatccaa atctacaaac tttaacaatg caagtcttac tctaattttt     2340

aagtattttt gttggtactt acatgggtta taaatcctct ctctggacat caatgtagag     2400

tccatctttc aagcacttta atttttttag ctgccaaagg gtatgaatta cattattgta     2460

tgctaatttc cctgaaatca atgccttcta tgttcaccac agggatacaa gcctgttatg     2520

tttgatggga aagaccacta caatctaatg gtgatctaaa ataacttttt tgggctgggt     2580

gcagtggctc atgcctataa tcttagcact ttgggaggcc aaggtaggag gattgcttga     2640

agctaggagt ttgagaccag cctgggcaac agggtaaggt cctgtctcta caagatcaaa     2700

aacttagccg ggtatggtgg tgcatgtgtg cctgtagtcc aagctacttg aaggctgaga     2760

caggaggatc ggttgagccc aggaggttgt ggctgcagtg agctgtgatg tgcccttatg     2820

ctatagcctg ggcaagagcg tgagaccctg tctcaaagaa gaaaaaaaga gaaaaataac     2880

tcttttgaac aaacagacaa attagctagt agtatggaga tgtataccct ctattacaca     2940

cataaaaccg taacaaaatt cattgtggtg tattataatt agttttgtga atagaaaaat     3000

aaagcactta tgtttaaatt tgttacagtg acttttaaag gattaatgtt gaatcacatt     3060

gtcagaattt tttcctcctc gctgttcaat tttgtagttt ttactctcaa aaaatgaaat     3120

tctcaaaatt atatagcttt ttgttttgtt tgaataaatg attcattcct gtttg          3175


<210> 1033
<211> 3347
<212> DNA
<213> Homo sapiens

<400> 1033
gctatttgac gtgcggctcg aggaaggcga aggtttttgt gttgctagcc ggggccagcg       60

gcggtggcgg cggcggcgga ggcgtcggtg gaggagggga ggcggcgagg aggcgcagct      120

cccgctgcac cgcgatcgac gctgcggagc gagcccaccc gccccgggag ctcgcctccc      180

cggtgctccc ccgccctccc cgccccccca gcggcgctgc ctcctccaaa tgagcgattc      240

gcccgctgga tctaacccaa ggacacccga aagcagcggc agcggcagcg gcggcggcgg      300

gaagaggccg gcggtgccgg cagcggtgtc cctcttgcca ccggcggacc ccctgcgcca      360

ggcgaaccgg ctcccgatca gggtcctgaa gatgctgagc gctcacaccg gtcacctcct      420

gcacccggag tacctgcagc cgctgtcctc cactcccgtc agccccattg agctggacgc      480

caagaagagc cccttggcgc tgctggctca gacctgctcg cagatcggca agccggaccc      540

gccgccctcc tccaaactca actcggtggc ggcggcggcc aacgggctgg gagcggagaa      600

ggaccccggc cgctcagccc cgggcgccgc ctccgcagcc gcggccctga agcagctggg      660

ggactcaccg gccgaggaca agtccagctt caagccctac tccaagggct ccggcggcgg      720

cgactcccgc aaagacagcg gctcctcctc ggtgtcttcc acctcctcct cgtcctcctc      780

gtccccggga gacaaggcgg gcttcagggt ccccagcgcc gcctgcccgc cctttccccc      840

gcatggagcg ccggtctccg catcctcgtc ctcgtcgtcg cccggcggct cccgcggcgg      900

ctccccgcac cactctgact gcaagaacgg cggcggggtt ggcggcgggg agctggacaa      960

gaaagaccag gagcccaagc ccagcccgga gccggcagcc gtgagccgcg gcggcggtgg     1020

ggagcccggg gcgcacggtg gcgccgagtc cggggcctcc gggcgcaagt ccgagccgcc     1080

ctcggcgctg gtgggggccg gccacgtggc gccggtgtct ccctacaagc cgggccactc     1140

ggtgttcccg ctgccgccct ccagcattgg ctaccacggc tccatcgtgg gcgcctacgc     1200

cggctacccg tctcagttcg tgcctggcct ggatcctagc aagtccggcc tcgtgggagg     1260

ccagctgtct gggggcctgg gcctgccgcc gggcaagccc cccagctcca gcccgctcac     1320

cggggcctcc ccgccctcct tcctgcaggg attatgccgc gacccctatt gcttgggagg     1380

ttaccacggc gcctcgcacc tcggcggctc cagctgctcc acctgcagcg cgcacgaccc     1440

tgccgggccc agcctgaagg cggggggcta cccgctggtg taccccgggc acccgctgca     1500

gcccgccgcg ctctcgtcca gcgccgccca ggccgcgctc cccggccacc cgctctacac     1560

ctacggcttc atgctgcaga acgaaccgct gccgcacagc tgcaactggg tggcagccag     1620

tgggccgtgc gacaagcgct tcgccacctc ggaggagctg ctcagccacc tacggaccca     1680

cacggccctg ccgggagccg agaaacttct ggccgcctac cccggggcct cgggcctggg     1740

cagcgccgcc gccgccgccg ccgccgccgc ctcctgccat ctgcacctcc ccccgcccgc     1800

cgcccccggc agccccgggt cgctgtcctt gcggaatcca cacactttgg gcctaagccg     1860

gtaccacccc tatggcaaga gccacttatc cacagcgggg ggcctggccg tgccgtccct     1920

ccccacagcc ggaccctact attcgccata cgcgctgtat ggacagagac tagcttcagc     1980

ctcggcgctg ggataccagt aactacagct cttcctccac cccagccccc tcaccctcct     2040

ccctctccct cctcctccct ccccacctgc cgtcgccgct gcaacctcca ctactgcttg     2100

accctgccgg gattccccac ccagcccttc cccaccggac tgtgtattta tttactataa     2160

tgttagctta caagctggga atataagtgc attaacggcc cacatgagtc aatggtatgc     2220

aaaaagtctg tgttctccca aataataata ttaatcccac aaataacgac atgatccccg     2280

cccctgttcc tttctgttat tttttcttag atataagttt tacatttttt attccttttc     2340

ctcttttttt ggttttgatt ggtttggttt gagggagagt tggggtcttt gggttcttct     2400

agacgttttg ttttcccttc ctggggagtt tcttgcatga gtcttaactt aaaactacgt     2460

ttccgccttc tctttttccc tcttccccct tcattccctc ttgtttcctt ccatttgcgg     2520

ttctgttttt gttttttgtt ttgttttgtt ttgttttttc ctttgttgta caagtaacag     2580

agaggaggtt ttttttgtaa ctcattttgg gggtggaggg ggccacctgg gtggcagggg     2640

ccctggagct ctattgacct ggtacactgc tccgggactc ctcccccgcc accctccgcg     2700

catagggtcc ttggtctgga ccctgccccc caaaagtagg gccttgctcc tctaccttgc     2760

tctgagcacg gagagccctg accccaccag taggctcgcc cccagaaggg cccaagtggc     2820

cgtctaccgt caccttccag actcccgccc ctaacaccca gtggctacag tgcgcctgtc     2880

ggggcacctg gagcgctcac ctggttgaat tcaaagtccc agaaggcccc gctggcgtga     2940

agccggcccc ttacattttg cgaagtgcat tatagtcctt gtttttctct ccctcgtggg     3000

ggcaacgacc cctcccctgg cagtaggggt ggggtaggtg actctcgcta gatccctcca     3060

aagcagaccg gtggcgatgt cagcggatgt cacgagctcg ttagctgcgt tcggggaagg     3120

ttggggcgtc agggagctct cggatcacag cagcccccgc cctctcctag gcctggcccg     3180

gcagagcccc cagagtggac cccccagcga ctggggtctt ctccccactc ctccctcctt     3240

ctggtctgat gcggcagcgc gggggctgcg gggcctgttt gggacgaaca gagctctccc     3300

ttggtaagac ttattttgtt aataaatgga atacttggct atattca                   3347


<210> 1034
<211> 2789
<212> DNA
<213> Homo sapiens

<400> 1034
aggctaggcg tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg       60

ccccgcaggc ccaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc      120

ggaatttccc acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg      180

atcccagcat gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg      240

aggaggctgc agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg      300

tttctgaagg agaactagat cagttggctc agattcggcc attaatattc aattttcatg      360

agcagacagc catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata      420

tcatgcagga atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga      480

atcaaccaag caacagagaa aaaaatagat accgagatat tcttccatat gattcaacac      540

gcgttcctct tggaaaaagc aaggactaca tcaatgctag ttatattaga atagtcaatt      600

gtggagaaga gtatttttat atcgctactc aaggaccact gctgagcacc atagatgact      660

tttggcaaat ggtgttggaa aataattcaa atgttattgc catgataacc agagagatag      720

aaggtggaat tatcaaatgc taccattact ggcccatttc tctgaagaag ccattggaat      780

tgaaacactt ccgtgtattc ctggagaact accagatact tcaatatttc atcattcgaa      840

tgtttcaagt tgtggagaag tccacgggaa ctagtcactc tgtaaaacag ttgcagttca      900

ccaagtggcc agaccatggc actcctgcct cagcagatag cttcataaaa tatattcgtt      960

atgcaaggaa gagccacctt acaggaccca tggttgttca ctgcagtgcc ggcataggcc     1020

ggacaggggt gttcctatgt gtggatgtcg tgttctgtgc catcgtaaag aactgttcat     1080

tcaacatcat ggatatagtg gcccaaatga gagaacaacg ttctggcatg gttcaaacga     1140

aggagcagta tcacttttgt tacgatattg tgcttgaagt tcttcggaaa cttctgactt     1200

tggattaaga aagacttctg ttgcctctca cttgaaatta ccaagtgggt ttgcacctcc     1260

tcataaagaa catgtttgca ctgtgctgaa gggctttgct atgcatacaa tctgctttct     1320

tggtttatca gtttattttc tttctaaaag ctccctgaag ggcaatatca tttggcttgg     1380

ggtgatcagt gtttacttat tgatcttgct agacaatatc aaaataactt cccacatttt     1440

ccagtgaaac agatgttaca taaaacgatt gcagcttggc tatttggttg aagggattac     1500

agagcccaat aaaggattta aaatatattc attaagattt tatttggaaa ggtggctgga     1560

gagagctgag gatttccagg actttgtaag ttcttattct gggagaacat aaggccaata     1620

atcatgacct cttccaggca tttttaagac agatgtctat tcatgttctt tagctagagc     1680

ctgtactttt tgctggcatt tgaataaccc agtttaaaaa gagtccagtt agggtggact     1740

aactttggac acaaattggc ttccatttcc tacattttca tactgctgcc ttcctacagc     1800

tgctagacca agacctgttg gtctgggaag catttcatgg atagggagag ctcctctcgg     1860

tgaacagtcc aaaactaaaa tagatgttta tatagaaagc ccaagaggag acttttgcca     1920

tgcctgagtt ctttcctatc ccaccctaac acttaacata ttacttagtc tgctttgtta     1980

aaagcaagta ttacctttaa cttgcctctt actctttgcc ctttagctaa ctaataaagt     2040

ttgatatagg cattattata taattctgag tcattcatgg tatctctcat gtttgatgta     2100

tttttcaaac taagatctat gatagttttt tttccagagt tccattaaat catttatttc     2160

ctttactttc tcacctctgt tgaaacattt agaaactgga tttgggaacc caattttgga     2220

aaaccagatt catagtcatg aaaatggaaa cttccatatt ctgtttttga aaagatgtgg     2280

ccattattac agtaatttta ttataggact ttgcctcgta caattaatag tgatattttg     2340

gacaaggagt tctggtgaca agctatacct aattataagc tataaaacaa tagatatgag     2400

tgtttgtaca gtttaactca atggagatca gaatattcta tgtattgaga aaatgtttaa     2460

tatcaatcta taaatcttga atttctaaga ggcttatttt gttcttttgg ctgaatgagt     2520

atatttgaat tggttgaata attaataatt ctcattgtaa aaataattat atgccaaaaa     2580

tatatttgat gttaaatcaa atagatgatt ctgtttacat tgttcatatg aataataatc     2640

tgtgttaatt tcattttgat aattggcctt taatatttgt atctctaatt ttattttctc     2700

tctgttactg taaaataata gctataatgt ataacaattt tcttcagaag aattctatgc     2760

tattattaaa ataaaatatt tactgtgta                                       2789


<210> 1035
<211> 3670
<212> DNA
<213> Homo sapiens

<400> 1035
gtggtcttcc cgcgcctgag gcggcggcgg caggagctga ggggagttgt agggaactga       60

ggggagctgc tgtgtccccc gcctcctcct ccccatttcc gcgctcccgg gaccatgtcc      120

gcgctggcgg gtgaagatgt ctggaggtgt ccaggctgtg gggaccacat tgctccaagc      180

cagatatggt acaggactgt caacgaaacc tggcacggct cttgcttccg gtgttcagaa      240

tgccaggatt ccctcaccaa ctggtactat gagaaggatg ggaagctcta ctgccccaag      300

gactactggg ggaagtttgg ggagttctgt catgggtgct ccctgctgat gacagggcct      360

tttatggtgg ctggggagtt caagtaccac ccagagtgct ttgcctgtat gagctgcaag      420

gtgatcattg aggatgggga tgcatatgca ctggtgcagc atgccaccct ctactgtggg      480

aagtgccaca atgaggtggt gctggcaccc atgtttgaga gactctccac agagtctgtt      540

caggagcagc tgccctactc tgtcacgctc atctccatgc cggccaccac tgaaggcagg      600

cggggcttct ccgtgtccgt ggagagtgcc tgctccaact acgccaccac tgtgcaagtg      660

aaagaggtca accggatgca catcagtccc aacaatcgaa acgccatcca ccctggggac      720

cgcatcctgg agatcaatgg gacccccgtc cgcacacttc gagtggagga ggtggaggat      780

gcaattagcc agacgagcca gacacttcag ctgttgattg aacatgaccc cgtctcccaa      840

cgcctggacc agctgcggct ggaggcccgg ctcgctcctc acatgcagaa tgccggacac      900

ccccacgccc tcagcaccct ggacaccaag gagaatctgg aggggacact gaggagacgt      960

tccctaaggc gcagtaacag tatctccaag tcccctggcc ccagctcccc aaaggagccc     1020

ctgctgttca gccgtgacat cagccgctca gaatcccttc gttgttccag cagctattca     1080

cagcagatct tccggccctg tgacctaatc catggggagg tcctggggaa gggcttcttt     1140

gggcaggcta tcaaggtgac acacaaagcc acgggcaaag tgatggtcat gaaagagtta     1200

attcgatgtg atgaggagac ccagaaaact tttctgactg aggtgaaagt gatgcgcagc     1260

ctggaccacc ccaatgtgct caagttcatt ggtgtgctgt acaaggataa gaagctgaac     1320

ctcctgacag agtacattga ggggggcaca ctgaaggact ttctgcgcag tatggatccg     1380

ttcccctggc agcagaaggt caggtttgcc aaaggaatcg cctccggaat ggcctatttg     1440

cactctatgt gcatcatcca ccgggatctg aactcgcaca actgcctcat caagttggac     1500

aagactgtgg tggtggcaga ctttgggctg tcacggctca tagtggaaga gaggaaaagg     1560

gcccccatgg agaaggccac caccaagaaa cgcaccttgc gcaagaacga ccgcaagaag     1620

cgctacacgg tggtgggaaa cccctactgg atggcccctg agatgctgaa cggaaagagc     1680

tatgatgaga cggtggatat cttctccttt gggatcgttc tctgtgagat cattgggcag     1740

gtgtatgcag atcctgactg ccttccccga acactggact ttggcctcaa cgtgaagctt     1800

ttctgggaga agtttgttcc cacagattgt cccccggcct tcttcccgct ggccgccatc     1860

tgctgcagac tggagcctga gagcagacca gcattctcga aattggagga ctcctttgag     1920

gccctctccc tgtacctggg ggagctgggc atcccgctgc ctgcagagct ggaggagttg     1980

gaccacactg tgagcatgca gtacggcctg acccgggact cacctcccta gccctggccc     2040

agccccctgc aggggggtgt tctacagcca gcattgcccc tctgtgcccc attcctgctg     2100

tgagcagggc cgtccgggct tcctgtggat tggcggaatg tttagaagca gaacaagcca     2160

ttcctattac ctccccagga ggcaagtggg cgcagcacca gggaaatgta tctccacagg     2220

ttctggggcc tagttactgt ctgtaaatcc aatacttgcc tgaaagctgt gaagaagaaa     2280

aaaacccctg gcctttgggc caggaggaat ctgttactcg aatccaccca ggaactccct     2340

ggcagtggat tgtgggaggc tcttgcttac actaatcagc gtgacctgga cctgctgggc     2400

aggatcccag ggtgaacctg cctgtgaact ctgaagtcac tagtccagct gggtgcagga     2460

ggacttcaag tgtgtggacg aaagaaagac tgatggctca aagggtgtga aaaagtcagt     2520

gatgctcccc ctttctactc cagatcctgt ccttcctgga gcaaggttga gggagtaggt     2580

tttgaagagt cccttaatat gtggtggaac aggccaggag ttagagaaag ggctggcttc     2640

tgtttacctg ctcactggct ctagccagcc cagggaccac atcaatgtga gaggaagcct     2700

ccacctcatg ttttcaaact taatactgga gactggctga gaacttacgg acaacatcct     2760

ttctgtctga aacaaacagt cacaagcaaa ggaagaggct gggggactag aaagaggccc     2820

tgccctctag aaagctcaga tcttggcttc tgttactcat actcgggtgg gctccttagt     2880

cagatgccta aaacattttg cctaaagctc gatgggttct ggaggacagt gtggcttgtc     2940

acaggcctag agtctgaggg aggggagtgg gagtctcagc aatctcttgg tcttggcttc     3000

atggcaacca ctgctcaccc ttcaacatgc ctggtttagg cagcagcttg ggctgggaag     3060

aggtggtggc agagtctcaa agctgagatg ctgagagaga tagctccctg agctgggcca     3120

tctgacttct acctcccatg tttgctctcc caactcatta gctcctgggc agcatcctcc     3180

tgagccacat gtgcaggtac tggaaaacct ccatcttggc tcccagagct ctaggaactc     3240

ttcatcacaa ctagatttgc ctcttctaag tgtctatgag cttgcaccat atttaataaa     3300

ttgggaatgg gtttggggta ttaatgcaat gtgtggtggt tgtattggag cagggggaat     3360

tgataaagga gagtggttgc tgttaatatt atcttatcta ttgggtggta tgtgaaatat     3420

tgtacataga cctgatgagt tgtgggacca gatgtcatct ctggtcagag tttacttgct     3480

atatagactg tacttatgtg tgaagtttgc aagcttgctt tagggctgag ccctggactc     3540

ccagcagcag cacagttcag cattgtgtgg ctggttgttt cctggctgtc cccagcaagt     3600

gtaggagtgg tgggcctgaa ctgggccatt gatcagacta aataaattaa gcagttaaca     3660

taactggcaa                                                            3670


<210> 1036
<211> 837
<212> DNA
<213> Homo sapiens

<400> 1036
gccggcgcca gacgcggagg gaaggagcta cgagtagccg ccgagaggcc gcggagccag       60

cgacgaccga cccagccgag ccgccgccgc cgccgcgccc ccatggcggc cgccaaggac      120

actcatgagg accatgatac ttccactgag aatacagacg agtccaacca tgaccctcag      180

tttgagccaa tagtttctct tcctgagcaa gaaattaaaa cactggaaga agatgaagag      240

gaacttttta aaatgcgggc aaaactgttc cgatttgcct ctgagaacga tctcccagaa      300

tggaaggagc gaggcactgg tgacgtcaag ctcctgaagc acaaggagaa aggggccatc      360

cgcctcctca tgcggaggga caagaccctg aagatctgtg ccaaccacta catcacgccg      420

atgatggagc tgaagcccaa cgcaggtagc gaccgtgcct gggtctggaa cacccacgct      480

gacttcgccg acgagtgccc caagccagag ctgctggcca tccgcttcct gaatgctgag      540

aatgcacaga aattcaaaac aaagtttgaa gaatgcagga aagagatcga agagagagaa      600

aagaaagcag gatcaggcaa aaatgatcat gccgaaaaag tggcggaaaa gctagaagct      660

ctctcggtga aggaggagac caaggaggat gctgaggaga agcaataaat cgtcttattt      720

tattttcttt tcctctcttt cctttccttt ttttaaaaaa ttttaccctg cccctctttt      780

tcggtttgtt tttattcttt catttttaca agggacgtta tataaagaac tgaactc         837


<210> 1037
<211> 2573
<212> DNA
<213> Homo sapiens

<400> 1037
cacgccggcg ctccaggcgc ggcaggctgc cgcccccgga agtagtgggt accgggacgc       60

cgtgaggcgg aagctgtgta tggcgggagg ctgtggcggt cccttggtgg ggaagctgtt      120

gctgttgcta gacgacggga actagctctc gtcacttcct cagcccgccg tctgcccact      180

cctctagccg gaacctgggg gcccggagcc ggggtaggca cagagttgtc ctcggaggtc      240

caggacagcg gccagcccgg cggcgggagt cagggccacg ccacctgcag ggaagaaccc      300

gagtcgaagc gggaagatgg ctgcagacaa gcctgcagat cagggagcag agaaacatga      360

aggcacaggt cagtcctctg ggatcactga tcaagagaag gagttatcca ccaatgcttt      420

ccaagctttc acatctggaa attatgatgc ctgtctacaa caccttgcct gtctacaaga      480

tataaacaaa gatgattata aaataatttt gaatacagca gtagctgagt tttttaaaag      540

taaccaaaca acaacagata atttgagaca aacacttaac cagctgaaga atcaggtcca      600

ctcagctgtt gaagaaatgg atggattaga tgatgttgaa aacagcatgt tgtactataa      660

tcaagcagtc attctttatc atctgcggca gtatacagaa gccatatcag ttggtgaaaa      720

actttatcag ttcatagagc cttttgaaga aaaatttgcc caagcagtgt gttttttgct      780

tgtagacctg tatatattaa cctaccaagc tgagaaagct ttgcatcttc ttgctgtcct      840

agaaaaaatg atttcacagg gtaacaataa caaaaatgga aagaatgaga ctggtaataa      900

caacaacaaa gatggatcta atcataaagc tgaaagtgga gctctaatag aagctgcaaa      960

atcaaagata catcagtaca aagtacgagc ttatatccaa atgaagtctc tgaaagcatg     1020

taaaagggaa atcaagtcag tcatgaatac agctggaaat tccgcaccct ctctctttct     1080

taaaagcaat tttgagtact taagaggtaa ttatcgaaaa gccgtgaagc tattaaatag     1140

ttcaaacatt gctgagcatc caggattcat gaaaacaggt gaatgcttga gatgcatgtt     1200

ctggaataac cttggttgca tccattttgc catgagcaag cacaatttgg gaatattcta     1260

ctttaaaaag gctctgcaag agaatgacaa tgtctgtgca cagctcagtg caggtagcac     1320

tgatccaggt aaaaaatttt caggaagacc catgtgtacg ttactaacca ataagagata     1380

tgagttgctg tataactgtg gaattcagct tcttcacatt ggaaggcctc ttgctgcctt     1440

cgaatgtctg attgaagctg ttcaggttta tcatgcaaat cctcgcctct ggctacggct     1500

ggctgaatgc tgcattgctg ccaataaggg gacttctgaa caagaaacta aaggccttcc     1560

cagcaaaaaa ggaattgtac agtctattgt tggtcaaggc tatcatcgta aaatagtttt     1620

ggcatcacag tctatacaga atactgttta taatgatggg cagtcttcgg ccattcctgt     1680

agccagtatg gagtttgcag ccatatgtct cagaaatgcc ttgttgctgc tacctgaaga     1740

acagcaagat ccaaagcagg aaaatggggc taaaaatagt aatcaattag gtgggaacac     1800

agagagcagc gaaagcagtg aaacttgcag gtgctccata cttgcttgca gtgcctacgt     1860

ggctctggct ttgggtgata acctcatggc tttgaatcat gcagataaac ttcttcagca     1920

gcccaagctg tcaggatctc ttaagttttt gggacattta tatgctgcag aagccctcat     1980

ctctctcgac agaatatctg atgccattac tcacttgaac ccggagaatg tcactgatgt     2040

ctccttaggg atctcttcaa atgagcagga ccaaggatca gacaaaggtg aaaatgaagc     2100

aatggaatcc tctggtaagc gggcccctca gtgctacccc agttccgtca actctgccag     2160

gactgtgatg ctgttcaacc ttggcagcgc ttactgcctg aggagcgaat atgacaaagc     2220

ccgaaagtgt ctccaccagg cggcttcaat gatccatcct aaagaggtgc cccctgaggc     2280

catcttgctg gcagtctacc ttgaactgca gaatggtaat actcagctgg ccttacagat     2340

catcaaaagg aatcagctgc tccctgcagt gaaaacacac tctgaagtga gaaagaagcc     2400

agtgtttcag cctgtccacc cgatccagcc catccaaatg ccggctttca ccactgtgca     2460

gagaaagtga tacttcactt ttggaaaact gttacctgag acccagggga gaatttactg     2520

gccattttag ttgtatcaca gcagaatgaa taaaagatgg tgaaggctgt taa            2573


<210> 1038
<211> 2056
<212> DNA
<213> Homo sapiens

<400> 1038
caggatgtac caaacgtgga agcggagacg gggaggtctg ggggtgccac gcaagtccct       60

ttcctcccga cacgagtgca gtaaagaaaa acggttatga gcgtaaagtg acagcctcgg      120

ccgatgggaa tagggggaag tccgacactg agcaacgaac gcattcccgc gcctccaaaa      180

cctaggccgg gggcgctgga aacccttacc ggcacccggc caccgcggca gacgcttgct      240

cctgccacgc cccccccccc tcccccgcat cacgtgtctg cactcgcttt cctcggattc      300

ccggatgtgg ttgccaaaac aaaggggatt tggtgatgga ggctttgtta gaaggaatac      360

aaaatcgagg gcatggtggg ggatttttga catcttgtga agcagaacta caggagctca      420

tgaaacagat tgacataatg gtggctcata aaaaatctga atgggaagga cgtacacatg      480

ctctagaaac ttgcttgaaa atccgtgaac aggaacttaa gagtcttagg agtcagttgg      540

atgtgacaca taaggaggtt ggaatgttgc atcagcaggt agaagaacat gaaaaaatca      600

agcaagagat gaccatggaa tataagcagg agttgaagaa actacatgaa gaattatgca      660

tactgaagag aagctatgaa aagcttcaga aaaagcaaat gagggaattc agaggaaata      720

ccaaaaatca cagggaagat cggtctgaaa ttgagaggtt aactgcaaaa atagaggaat      780

tccgtcagaa atcgctggac tgggagaagc aacgcttgat ttatcagcaa caggtatctt      840

cactggaggc acaaaggaag gctctggctg aacaatcaga gataattcag gctcagcttg      900

tcaatcggaa acagaaatta gagtctgtgg aactttctag ccaatcagaa attcaacact      960

taagcagtaa actggagcgg gctaatgaca ctatctgtgc caatgagttg gaaatagagc     1020

gcctcaccat gagggtcaat gacttggttg gaaccagtat gactgtccta caggagcagc     1080

agcaaaaaga agaaaaattg agggaatctg aaaaactatt agaggctctg caggaagaaa     1140

agagagaatt gaaggcagct cttcagtctc aagaaaatct catacatgag gccagaatac     1200

aaaaggagaa gttacaagaa aaagtaaagg caactaacac tcaacatgct gtagaagcta     1260

taagtttgga atctgtgagt gcaacgtgta aacagctgag ccaagaacta atggaaaaat     1320

atgaagaact gaagaggatg gaagcacata acaatgaata caaagcagag attaagaagt     1380

tgaaagaaca gattttacag ggtgaacaaa gttacagttc tgcactagaa ggaatgaaga     1440

tggaaatctc ccatctaact caggagttac atcagcgaga tatcactatt gcttccacca     1500

aaggttcttc ctcagacatg gaaaagcgac tcagagcaga gatgcaaaag gcagaagaca     1560

aagcagtaga gcataaggag attttggatc agctggagtc actcaaatta gaaaatcgtc     1620

atctttctga aatggtgatg aaattggaat tgggtttaca tgagtgttcc ttgcctgtat     1680

ctccccttgg ttcaatagct accagatttt tggaagagga ggaactgagg tctcatcaca     1740

ttctagagcg cttggatgcc catattgaag aactaaaaag agagagtgaa aagacagtga     1800

gacaattcac agccttaaag tagcctctta aaaaaatcac tatcttggaa ataaaaataa     1860

acaccaaaga gttactgtca tctgaagtag cagctcttta aaaacatgaa gagataaaat     1920

tataaaaatg atacatctaa agcagtggtg aagaaagctg aaaaactgat acttttgata     1980

ggcattttct ctgcactggt ttgtttaaag gacttcttcc agcaataagt tgaaagaata     2040

aaccactttg ctagac                                                     2056


<210> 1039
<211> 4699
<212> DNA
<213> Homo sapiens

<400> 1039
gggaccaaga gcggaagtgg gtgtgacggg gacgggggcc cggtgggccc gcggaggaaa       60

gatactgggg agtgggagcc gcggggttca gagcgatgat tcccccacag gaggcatccg      120

ctcgacggcg ggagattgag gacaagctga agcaggagga ggagactctg tccttcatcc      180

gagacagcct ggagaagagc gaccagctca ctaagaacat ggtgtctatc ttatcatcct      240

ttgagagccg ccttatgaag ctggagaact ccatcatccc tgtgcacaag cagacggaga      300

atctgcagcg gctgcaggag aatgttgaga agacgctgtc ctgcctggac catgtcatca      360

gctactacca tgtggccagt gacactgaga agatcatcag agagggcccc acaggtaggc      420

tggaagagta cctgggaagc atggccaaga ttcagaaggc agtggagtat ttccaggaca      480

acagcccaga cagcccggaa ctcaacaaag tgaaactgct ctttgagcgc gggaaggagg      540

ccctggagtc cgaatttcgc agcctgatga cgcggcacag taaggtcgtc tcgcccgtgc      600

tcatcttgga tctgatcagt ggtgacgatg atctggaggc ccaggaggac gtgaccctgg      660

agcacctgcc cgagagcgtg ctccaggatg tcattcgcat ctcccgctgg ctggtggaat      720

atggccgcaa ccaagatttc atgaacgtct actaccagat acgctccagc cagctggacc      780

gctccatcaa aggactgaag gagcatttcc ataagagcag ttcttcctct ggggttccct      840

actcccctgc tatccccaac aagaggaaag acacacctac caagaagcca gtcaagcggc      900

cagggagaga tgacatgctg gacgtggaga ccgatgccta catccactgc gtcagtgcct      960

tcgtcaagct ggcgcagagc gagtaccagc tgctggccga catcatcccc gagcaccacc     1020

agaagaagac cttcgactcc ctgatacagg atgccctgga tgggctgatg cttgaagggg     1080

agaacatcgt gtctgctgcc cggaaggcca ttgtgcgaca cgacttctcc acggtgctca     1140

ccgtcttccc catcctgcga cacctcaagc agaccaagcc tgagtttgac caggtgctcc     1200

agggcacggc tgccagcaca aagaacaagc tgcctggcct catcacatcc atggagacca     1260

tcggtgccaa agcgctggag gacttcgcag acaacatcaa gaatgacccg gacaaggagt     1320

acaacatgcc gaaggacggc accgtacacg agctcaccag caatgccatc ctcttcctgc     1380

agcagctttt ggacttccag gagacggcag gcgccatgct ggcctcccaa gagaccagct     1440

cttcggccac cagctacagc tctgagttca gcaagcggct gctaagcacc tatatctgta     1500

aagtgctggg caacctgcag ttgaacttgc tgagcaagtc caaggtgtac gaggacccag     1560

ctctgagcgc catcttcctg cacaacaact acaattacat cctcaagtcc ctggagaagt     1620

ctgaactgat ccagctggtg gcagtgacac agaagactgc tgagcgctcc taccgggagc     1680

acattgagca gcagatccag acctaccagc gcagctggtt aaaggtgact gattacatcg     1740

cagagaagaa tctacctgtg ttccagccgg gagtcaagct ccgggacaag gagcggcaga     1800

ttatcaagga gcgttttaag ggcttcaatg atggcctcga agaactgtgc aaaatccaga     1860

aggcctgggc tattccagac acagagcaga gggacaggat tcgccaggcc cagaagacca     1920

ttgtcaagga gacctacggg gcctttctac agaagtttgg cagcgtgccc ttcaccaaga     1980

acccggagaa gtacatcaag tacggggtgg agcaggtggg cgacatgatc gatcgccttt     2040

tcgacacctc tgcctgagcc tgctgctagc cctgcctggt tccaccagac tggcgtgtca     2100

ttggacagat aaaccagtgt tagcttgcct ctgggctggg tgagcttgaa gtcctctggg     2160

acagagacct gtctccacgc ctccgggagc tgtgtccctg agccccctag tcctggctcc     2220

tgctttttcc ccacagcccg tgttcccagc cgaaccagca ctctcccgga agcctggggt     2280

ccctccacac cttggctttt atgaccctga tggcttctga aacaggaaaa gagagaagga     2340

agacagaggc ctgtgcccac tgctgctcca tgtgtaccaa gagcagcagg gcagaagggc     2400

cctccctcca gcctaggtca gaggtgggga cagagaactc ccctacagcc cagagatgtg     2460

gcagggctca gagaagcagc cagagctcct ggaggaaagg cagtcgggac tgaccccctc     2520

tcttaaaaca cattcccgcc cgcccacagg cctgaggtct gggacctttc cctcccagga     2580

gtcccctagg tggctggggg aggcaggctc actggccatt ttccctagag tccagcacac     2640

tgcaggaggc gttcggagga ggagttccgc cccaccctct acagccttcc tcaggcccct     2700

gtctctggcc cccagcctca gtgcctcttg gcccagggcc aggcagtcgt ggttgcagaa     2760

ggagcaatta ggctgcctgc ctgtgggctg ggagacaggg acaatgggga aaagttaagg     2820

agcaaaatgg gggttggaag caaaaaatag ggccccacct atttaggacg agattgaaga     2880

ctgacccttg aggcacactt gcactggaga tgggtttatt tcacgctctg tgcttgtgtg     2940

ctagcggagg gagagctcag ggtggcttaa tccagaggcc ctgtcatggc ccgcccccag     3000

ccatgggaaa gcaaacttca tcctaaggtg tgcagcccag gccctgcccc tttacagtct     3060

aggccgcctg ccatggggtg cagcctctcc aggggctgcg tcagacttgc acgctgccca     3120

catccagatt cctgcaaaga cgaattgggt gcacagcacc ccaaccacat acacgaggaa     3180

gaagatgcgg tcagcagtct caggccagct tctctgtgac ccctttactc ctctggaggg     3240

ctctgtgggg agagatacag ggaaaggagc tgttcttcaa ggtcccctca acatgagcgg     3300

aagagcgaac cccaggggtc atcagcctgt atcgcttcct ttcttagatt ctcagctgat     3360

gaaaatttgg gtctggccca tttcaggcca tcttcagttg aagaaacacc ctcttaggct     3420

gtgcaaggca tgggttatca ggggattgag gtcacctggg acttcaggga ggctcagctt     3480

gctccctgcc ccagacctgt ttcttctaag ggaggaggac atggtggaga ccagggacag     3540

gagagccagc agggtggatg caaggggcct ctacccacac ctggacctcc gtgccctcac     3600

cccagcccta ggtgtgcacc taggcctcat tccttacccc ccagcccctg cccaccttca     3660

gcaggatgag gccctgggtt gccgtgctct cgctgttccc ctctcggggc tgggctgggg     3720

ccgctcttgg ccccaaggtt gccccgggcc agcagcccag ccagcagcac agtctctatg     3780

gtgctgagga agagcagcag cagcaggatg gtgaagtagt aaactggggg aggcagggca     3840

cagggagatg ctcaggggcc agtccctgtg tctctggtgc ccagcgagct gagcaccagt     3900

gggtgaccgg ggagaaacag ggcagactgg gtaagggagc agggcttact gagcagtggg     3960

ttgcaggagg aggagctggg cagggcctgc accagggagg agtggaggac gaggtaactc     4020

agcagcaatg tcaccttgta gcctatgcgc tcaatggccc ggaggggcag caaccccccg     4080

cacacgtcag ccaacagcag tgcctctgca ggcaccaaga gagcgatgat ggacttgagc     4140

gccgtgttct tcagcctcag ctggaagggg aaaagtcagg gccttcccgg cgggggggaa     4200

ggaggtgggc atcgggggca tggggcctgg cctctggccg tgcatcctca ctcccacccg     4260

cctccagcag ccctctgtcg gcctcctccc gacttgactc accgtcacct ggaagcaggg     4320

caccagctgc tggggtggga cttgggtctt cagatcataa actacgtatt ccctcttgac     4380

actcacaatc tcgttcacca cgtgggcctg gaactctaac tccatcgctg aggggtggga     4440

atgagaacta tgaaccagga aggagagatc ccagctgcca agtctggggg tagcagactg     4500

gagcccaggg gtgatggaga cttttgatgg cttttggcag ggacagactt ggacacaaaa     4560

ccgatccata gaagggcttc ccaaaccttg ttttgcaaca tcccaaattg tctccagttg     4620

aaggaaggcc tttatcagat tcatagatga gctttcattg taaaaataaa tgtactttgc     4680

accacttcat gatggaggg                                                  4699


<210> 1040
<211> 3390
<212> DNA
<213> Homo sapiens

<400> 1040
agaaggggaa acaggaatcg attaggaata aaggattata atccactttc cttctgagga       60

aaagctggga accttctcat tttgccttat gaaaactaag ctgaatcgac tgctgccaaa      120

catctattag gcaaaattgg cctcttgccc atgatttgac tttccagcac agccagttct      180

ttttctcctc tgcagctgat tggctctgga gtgtggccag aagcctctct cctgcaatta      240

aaggagtcgg gtctctaact gttgatctgt ttttttccct tctgagcaat ggagcttacc      300

atctttatcc tgagactggc catttacatc ctgacatttc ccttgtacct gctgaacttt      360

ctgggcttgt ggagctggat atgcaaaaaa tggttcccct acttcttggt gaggttcact      420

gtgatataca acgaacagat ggcaagcaag aagcgggagc tcttcagtaa cctgcaggag      480

tttgcgggcc cctccgggaa actctccctg ctggaagtgg gctgtggcac gggggccaac      540

ttcaagttct acccacctgg gtgcagggtg acctgtattg accccaaccc caactttgag      600

aagtttttga tcaagagcat tgcagagaac cgacacctgc agtttgagcg ctttgtggta      660

gctgccgggg agaacatgca ccaggtggct gatggctctg tggatgtggt ggtctgcacc      720

ctggtgctgt gctctgtgaa gaaccaggag cggattctcc gcgaggtgtg cagagtgctg      780

agaccgggag gggctttcta tttcatggag catgtggcag ctgagtgttc gacttggaat      840

tacttctggc aacaagtcct ggatcctgcc tggcaccttc tgtttgatgg gtgcaacctg      900

accagagaga gctggaaggc cctggagcgg gccagcttct ctaagctgaa gctgcagcac      960

atccaggccc cactgtcctg ggagttggtg cgccctcata tctatggata tgctgtgaaa     1020

tagtgtgagc tggcagttaa gagctgaatg gctcaaagaa tttaaagctt cagttttaca     1080

tttaaaatgc taagtgggag aagagaaacc ttttttttgg ggggcggttt ttttggtttg     1140

ttgttggttt tttttttttt tttggcggga agaaagagtt ttgctcttgt tgcccaggct     1200

ggagtgcaat gacgtgatct ccgctcactg caacctccac ctcgcgggtt taagcgattc     1260

ttctgcctca gcctccctag tagctgggat tacaggtgcc caccaccatg cccagctaat     1320

ttgtattttt agttgagaca gggtttcact acgttggcca ggctggtctt gaactcctga     1380

tctcaggcaa tccacccacc tcagcctccc aaagtgctgg gatgacaggc gtgagcaacc     1440

gcacccagct taaggttttt ttgttttgtt ttgagacgga gttttcgctc ttgttgccca     1500

ggctggagtg caatgctgtg atctcagctt accacaacct ccacctcccg ggttcaagtg     1560

attcacctgc ctcagcctcc tgagtagctg gtattacagg catgcgtcac cacgccggct     1620

aattttgtac ttttagtaga gatggtgttt ccccacgttg gtcagtctgg tctcaaattc     1680

ctgacctcag gtgatctgcc tgcctcggcc tcccaaagtg ctgtgattac agacgtcagc     1740

caccatgcct ggcctgaaac cttttttagg taaagttgaa ttccatcctt aaaagtttct     1800

gttatatcct atttagccat tttctattgt ctcccaaaga attcacatca aaaaaacagc     1860

tttgaactcc cccttcaaag gaaacagtcg actttcataa ttagcatcta ccattatccc     1920

caaatcttat tttattcatt gacttgaaat tttttccaat tgcttttttt tttttttttt     1980

taaggttaag agcagaggtt tactaggcca aagaaagaga atagctctct gttgcagaga     2040

ggggtcctgg agaaatgggt taccccagtt gtcttattta aatggttacc catcagattt     2100

taattttatc ttctctttga gagcttggta ataagaagca cttaaatcac tccaaagaag     2160

actttaaaaa gggagcagtg aaaaggtctt aataatttat tgattgaatt aagaaatact     2220

agctaattaa gaatctgagt ctaaacagca cagatttttt ctttctgctt ttaaattgtg     2280

ttttaaaaaa agagacaggg ggctgggcgt ggtggctcac gcctgtaatc ctagcacttt     2340

gggaggccga ggcgggtgga tcacgaggta ggagttaaag accagcctgg ccaacatggc     2400

aaaaccctac taaagataca aaaaaaaaaa aaaattagcc aggcgtggtg gtgggtgcct     2460

gtaatcccag gtacttggaa ggctgaggca ggagaatctc ttgaacccag aaggcgaagg     2520

ttgcagtgaa ccgagatcat gccattgtac tctagcctgg gtgacaagag caagactccg     2580

tctcaaaaaa aaaaaaaaaa aaaaaaagaa gtagagacag ggagacaggg tctcactgtg     2640

ttgcctaggc cggtcttgaa ctcctgggct caagtgattc tcccaccttg acctcctaaa     2700

ttgttgggat tacaggtgtg agacagtgca cctggccgaa atagctcaag tttctgaaaa     2760

acaaatctga atctatttgt tattcttagc gtcactggtc tggctttcag aattaacata     2820

caaggttgcc acacctagtt ctgcccagct ttatgtcttt tattccagta ttccaccaaa     2880

gtttgttttc ctgcattcca gttctcaagt cttaagataa agattgtact tgacagttta     2940

gtatatccat aaaactattt gaggtggtta aggttcttgg gttcattttc cttaatactt     3000

tgctgaatat tgtagattgt aggcaatgaa aaagtctact aaattaggaa aaccttgaat     3060

aattaggtat cctaggtaag agcccctaaa catcaagcaa tctgtgagtc tgtaaagaaa     3120

taaatatttt ttggattatt cttatctaat tccacccctg ttggaagatg atttctttgt     3180

tctttgcaac tatggaagct gtgaaaatca tcacaagtgc ctctgaaagc gagtgttagg     3240

ttggttagag ggtttaatat tttctgcaat ggtttgtagg aattttaata aatgtagtat     3300

attttctgag atgattttgt aaaagtacta ttttaaatat caaatcaacc aataaattca     3360

catttgtgtt aggaacagaa atatggttta                                      3390


<210> 1041
<211> 5812
<212> DNA
<213> Homo sapiens

<400> 1041
aagtcacgtg ctgtgacagt agctggggtg aggccgtcgt cgccgcacgg gctggttggg       60

gctgtgtctg tgggaggcgc cggggtgatg gcggtggaga ctctgtcccc ggactgggag      120

tttgaccgcg ttgacgacgg ctcgcagaaa attcatgccg aagtccaact taagaattat      180

gggaaatttc ttgaggagta tacctctcaa ctgagaagaa ttgaggacgc tctggatgac      240

tcaattggag atgtttggga tttcaatctt gatcctatag cattaaagct tttgccttat      300

gaacagtcct ctcttttgga actcataaag actgaaaaca aggtcttaaa caaagtcatc      360

actgtttatg ctgcactttg ttgtgaaatc aagaaattaa aatatgaggc tgaaactaaa      420

ttttacaatg gtctcttgtt ttatggagaa ggagctacag atgccagcat ggtggaaggt      480

gattgccaaa ttcaaatggg gagatttatt tcattcttac aggaactgtc ttgctttgtt      540

acgaggtgct atgaagtggt gatgaacgta gtccaccagt tggctgccct ctatatcagt      600

aacaagattg cacccaaaat tatagagaca actggagttc attttcagac tatgtatgag      660

cacttgggag aactgctaac agttttgctc accctggatg aaattattga taatcatatc      720

acactgaaag accactggac tatgtacaaa aggttactga aatctgtcca tcacaatcct      780

tcaaaatttg gaattcagga agaaaaatta aagccatttg aaaagttctt gctgaagcta      840

gaagggcaat tactggatgg aatgatattc caggcctgta tagaacaaca atttgattct      900

ctcaatggag gagtatctgt gtcaaaaaat agtacttttg ctgaggaatt tgcacatagt      960

attcggtcaa tttttgcaaa tgtagaagcc aaacttggag aaccttctga aattgaccag     1020

agagacaagt atgttggaat ttgtggactc tttgtattgc actttcagat ttttcgaact     1080

attgataaaa agttttataa gtctttattg gacatttgta agaaggtacc agccatcact     1140

ctaactgcta atattatttg gtttcctgat aattttctga tccagaaaat accagcagct     1200

gccaaactgc tagacagaaa aagtcttcaa gccattaaaa tacacaggga tacttttcta     1260

caacagaaag ctcaatcact taccaaagat gtacagtctt actacgtctt tgtgagctca     1320

tggatgatga aaatggaatc tattttgtct aaagagcaga gaatggataa atttgctgaa     1380

gatctcacca atagatgtaa tgtttttata cagggcttct tgtatgcata tagtattagt     1440

accattatta aaaccacaat gaatctctac atgtccatgc aaaagccaat gaccaaaacc     1500

tcagttaagg cattgtgcag gcttgttgaa cttctcaagg caatagagca tatgttctac     1560

aggagaagca tggttgtggc tgattcagtt tcacatataa cacagcacct tcaacatcag     1620

gctcttcatt ctatttctgt ggccaagaaa agagtgattt ctgacaaaaa atacagcgaa     1680

cagcgtcttg atgtgctctc tgctctagtt ttggctgaaa acactctaaa tggaccaagc     1740

acaaagcaac ggcgacttat tgtttctttg gcactaagtg ttggcacaca aatgaaaaca     1800

tttaaagatg aagaactctt tccacttcaa gtagtcatga aaaaactgga tcttattagt     1860

gaacttagag aacgagtcca aacacaatgt gactgttgtt ttttatactg gcatcgagct     1920

gtcttcccaa tttatttaga tgatgtatat gaaaatgctg ttgatgcagc cagattacat     1980

tacatgttca gtgctttgcg cgactgtgta cctgctatga tgcatgcaag gcatttagag     2040

tcctatgaga tacttctgga ttgctatgac aaggaaatta tggaaatttt aaatgagcat     2100

ttgctggaca aattatgcaa agaaatagag aaagatctgc gactttctgt gcatactcat     2160

ttaaagctgg atgaccgaaa ccctttcaaa gttggcatga aagacctggc tctttttttc     2220

tctctgaatc caattcggtt tttcaatcgt ttcattgaca ttcgggctta cgtaactcac     2280

tacctagaca agactttcta caatctaaca actgtagccc ttcatgactg ggccacttat     2340

agtgagatga gaaacttagc tactcagcgt tatggactgg ttatgacaga ggcacatctt     2400

cccagtcaga ctttggaaca gggccttgat gttttagaaa ttatgagaaa cattcatata     2460

tttgtgtccc gatacctcta taatctcaac aatcagattt ttattgaacg aacaagcaat     2520

aacaagcatt tgaatactat taatattcgg catattgcta attcaattcg aacacatggc     2580

acgggaatta tgaatacaac tgttaatttc acctaccagt ttttgaaaaa gaagttctat     2640

atatttagcc aatttatgta tgatgaacac atcaaatcca gattgattaa agatattcga     2700

tttttcaggg aaattaagga ccaaaatgat cataagtatc cttttgatag agcagaaaaa     2760

ttcaatcgag gcatcagaaa acttggagta acacctgagg gacagagcta ccttgatcaa     2820

ttcaggcaac tcatcagcca gattggtaat gctatgggct atgtacgaat gataagatct     2880

ggtggtcttc attgtagcag caatgccatt agatttgttc ctgatcttga agatattgta     2940

aattttgaag aactagtaaa agaagaaggt cttgcagaag aaacattaaa agcagcaagg     3000

catttggatt cagtcctcag tgatcacaca cgaaattctg ccgaaggcac agaatatttc     3060

aaaatgcttg tagacgtttt tgctccagaa tttcgaaggc caaagaatat acatctccga     3120

aatttctata taattgttcc ccctctgacc ctcaactttg tagagcattc cattagttgc     3180

aaggaaaaat taaataaaaa aaataaaatt ggagctgcct ttactgatga tggctttgcc     3240

atgggtgtgg cttacattct aaagcttttg gatcagtatc gggagtttga ttcacttcac     3300

tggttccagt ctgttagaga gaaatacctg aaggagataa gagcagttgc taagcaacag     3360

aatgtacagt cagccagtca agatgaaaaa ctcttacaaa ccatgaatct cactcagaag     3420

cgactggatg tctatctaca ggaatttgaa ttgctgtatt tctcactgag cagtgcaaga     3480

attttcttca gagcagacaa gactgcggct gaagaaaacc aagaaaagaa agagaaggaa     3540

gaagaaacta aaacaagcaa tggagacctg tctgacagca ctgtgtctgc tgatcctgtt     3600

gtgaaatgat acggatggta ttcactgcac atatgatgaa atcatcagaa ttgttaaaac     3660

ttttgccagt ggaatggata aactattgat gaattgtttc ctgggtcaca tctctggaaa     3720

atagatgtta cagttcttaa aggcagtgct ttaaagtgaa gttcattctg tttccaaagg     3780

ctctactttc aaaggttaag aatgagattt taaaattgga tttttgcctg gacttgaggg     3840

tacaagatgt ttctatttga agtgaagtta taaaagggca aatccagatt cataaactat     3900

cacctcggat ttcttgtaat ctacatgttt gtaatttgta tttgcataga tctttgatct     3960

atagttattt caagtcatgg gaaattcaat gcatatacta tatacagcca gtaaatacat     4020

gcttaacaaa aggaatgagc ctgaagttca taaagaatac atatcaatat tcttataaaa     4080

ggaatatatg aagatggctt tgatactaga ggtgaggcac aagtgtttta tgtactctca     4140

gtgtacagta taactgatga tccttctttc attgttaatt tcatgtgact cacaagagct     4200

gctgatgtct ttgatgagac attttataac tagtttacat tgctttgaga acatttaacc     4260

tccaacagct gctttaaatt taagatttac ttaatactca gaaaattcag ataaagccat     4320

agagtcctgt ttgaagcttc acttctattt tggttgaagg catgatgtat gatgtcagaa     4380

aaaaaattga atgaattatt tctacatcca aactcaggtt tcttctacat tagattgaat     4440

tgaaattttg gtgatggttt gggtagactt tttttttata tcaagtataa tttaaaacat     4500

cagattaaat aattacactg ttcaggcttt taaaaaaata ccactgtgag aataaagcgc     4560

tagcaagata catcacttac tgattttaaa aatacagaaa gattttgagt aaattttgtg     4620

cccagcaagc tgttagtttt atttttgtaa aggtatgtaa gttattaaat ggttaatcat     4680

ggccttttaa aaataaaata aagtgatacc tttacaatga agacaaaagt ttaaaacttt     4740

ctaatacaaa caccattttg ggaaatgctt gatttttttc tattgcattt gtctgctaaa     4800

catttctttg gataaatcct gcaaatactt ctaacattat tctttgattc cagcttttag     4860

aatgggtgta caatgccctg tttgtactta ctggttaggg tcagggtaac ttgccagccc     4920

aagataaata ctttaattgt taaaagtcag aagagacaga atatgtagga aatgtttttt     4980

gtttattatg taaacatggc ttacagaatt atgaacagtg gatagattaa aggcatttaa     5040

tatttgtaat tcataataac tgtagaaatg gccctaaagc atgctgcata attaataatt     5100

tatattttca ttattataag tgtttatatt aatgatcttg catttgatta tatcaaattc     5160

gtcatttcat agcaacagta ttgttttctc tgtttttctt ctctaacttc tctgaaatca     5220

tctcctatta agggatagaa attgttacta gaagagaatc acatgttctg tgttcattat     5280

ccctacacat gtaaattaat tattttatca atactagata gagttcacat gctgactccc     5340

tggataccta cagttgagaa gaaaatgaca gacaattatt tttcctttag gtcaaaataa     5400

tgtcactgct atctggataa attataagtt catatatttg aaataagatc ctggaaacga     5460

atttaaatgg tgtcaaactg cagagcaaca gggcttcagt atattcacat ctaataggtt     5520

aatatgtaca tttggatgat gatttttctt gataacatta acattaattt tattttttca     5580

gacatactgt aatttaaaaa ttaatgtgag cgtttgtttt aagttcacag aaaacttaat     5640

aattcaaatt ctcaggaatt aaggactcac cataacattg tcagttctaa tgaaattttg     5700

taaaagatgg caagtttgtt acctcacttg agtggggttt tccttttccc ccaattctaa     5760

gagaatataa tgtgtatact aaaacattaa taaacataat tttgaaaatt tc             5812


<210> 1042
<211> 1737
<212> DNA
<213> Homo sapiens

<400> 1042
acctgagctg agactagtgc ccctgtggag gggtagtgtg ggagggcccc cagggtgaca       60

cttggaggca aaggctggtt ctgggcagag tcacagtgag ctgggcagaa gcctcgcctg      120

aggatcccgt ggccccaatt tgtgtgcaga tagcagaggc agcaggccgt gccggggggg      180

catgttgctg taaccagtgg cccaggggat gttacggtgg acagtgcacc tggagggcgg      240

gccccgcagg gtgaaccatg ctgcagtggc tgtcgggcat cgggtatact ccttcggggg      300

ttactgctct ggtgaagact atgagacact gcgtcagata gatgtgcaca ttttcaatgc      360

agatacgcac aagtggttca caccccgagt gtcagggaca gttcctgggg cccgggatgg      420

acattcagcc tgtgtcctag gcaagatcat gtacattttt gggggctacg agcagcaggc      480

ggactgtttt tccaatgaca ttcacaagct agataccagc accatgacat ggactcttat      540

ctgtacaaag ggcagccctg cacgctggag ggacttccac tcagccacaa tgctgggaag      600

tcacatgtat gtctttgggg gccgtgccga ccgctttggg ccattccatt ccaacaatga      660

gatttactgc aaccgcattc gagtctttga caccagaact gaggcttggc tggactgtcc      720

cccgactcca gtgctgcctg aggggcgccg gagccactcg gcctttggct acaatgggga      780

gctgtacatc tttggtggtt ataatgcaag gctgaaccgg cacttccatg acctctggaa      840

gtttaatcct gtgtccttta cctggaaaaa gattgaaccg aaggggaagg ggccatgtcc      900

ccgccggcgc cagtgctgct gtattgttgg tgacaagatt gtcctctttg ggggtaccag      960

tccatctcct gaggaaggcc tgggagatga atttgacctt atagatcatt ctgacttaca     1020

cattttggac tttagcccta gtctgaagac tctgtgcaaa ctggccgtga ttcagtataa     1080

cctagaccag tcctgtttgc ctcatgatat caggtgggag ctgaatgcca tgaccaccaa     1140

cagcaatatc agtcgcccca tcgtctcctc ccatgggtag gaggaagttt ctgccacctc     1200

ccctcctgag cctgctgtca tcttcactgc ccctgcccat ctgtcaccca cctgctcctt     1260

tgacccctgg acttggtata cctccatgtg gagttgttgg gcgagaggtg ttctctgtgc     1320

tgtgaattca gtggggagct gtagcggggt gggggctagg ttcctccccc cttgggccga     1380

gggccccttc cccttggtgc tctgtcccca tccacctcct ttcagctgct cctgggcctc     1440

agctctgccc agggccagcc aggttctgct gggaagggaa gggaatgggg agaagggaga     1500

agcaagcagt gtctgagcct caggagcttc cccctccccc tttgcctatc ccctcccctc     1560

tgcttgagcc ttgagccttg actgggagct gaaaggagtt gcagctgttg gcatgagacc     1620

tccttctccc cgtcttgggg aggtggggac cagcagataa atcccaccct tccttgagct     1680

gtcgctgtac tctgaagttc agccagctca gattttataa aaattaatta aaatctc        1737


<210> 1043
<211> 3484
<212> DNA
<213> Homo sapiens

<400> 1043
gcctactttg gtgcagaggc gtggggggcg ggacgcgtct ttcccgttcg gatcgcgggg       60

aaagcagtgg ctccaagtga gccagaggag agctgaggag aggaggggga ggccgacgac      120

ctgggccctg ggcctctgaa ggcctacttt aaggctggcc aattctgcaa gaaaggcaag      180

gaggaggaga ctggctcaca gctctggagg acccccttct gtcagctgtg gggcttgaca      240

ccacttgaac aagaaaagga gggggaaact gcaccacatc agtgaagatc cacctccagt      300

ggctgctctg ctggtggtgg agttgctgct gacaaccacc ctcaacgggt ctgcacccat      360

ccaggaaata tctgtcttcc tttagcttgg ttgtacctgt tctcactcta tctgtattat      420

tgaattattg actgagactg tgtttgggaa ggaggctgag tgactactgg actggatatt      480

gactctaact cttattccca agcttatatc cttaatcacc taaagatcag agtgtgaaga      540

aacaaacctg tgacagatct gtggttgagg tttagactac gggaggagta tattacctga      600

ctttctttgt aacttgtacc atgactgggg cagagattga gcctagtgcc caggccaagc      660

ctgaaaagaa ggctggggaa gaggttatcg ctgggcctga gagagagaat gatgtccctc      720

tggtggtcag acccaaggtt aggacccagg caactactgg ggcaaggccc aaaactgaga      780

ccaagtctgt gcctgcggca aggcccaaaa ctgaggccca agcaatgtct ggggcaaggc      840

ccaaaactga ggtccaagta atgggtggtg caagacccaa aacggaggct caaggaatca      900

caggggccag gcccaaaacc gatgccaggg cagtaggtgg cgctcgttct aaaactgatg      960

ccaaggcaat ccctggagca aggcccaagg atgaggccca ggcatgggcc cagagtgaat     1020

ttgggactga agcagtgtca caggcagaag gagtgtccca gactaatgcc gttgcttggc     1080

cactggccac tgctgagtct ggatcagtta ctaaatctaa gggcctgtct atggatagag     1140

aactagtcaa tgtggatgct gaaacctttc ctggcaccca gggtcagaaa ggaatccagc     1200

cctggtttgg accaggggag gagactaata tggggtcttg gtgctattcc aggcccaggg     1260

ccagagagga ggcctctaat gagtctgggt tctggtcagc agatgagacc tctacagcgt     1320

cttctttctg gactggagaa gagacaagtg tcagatcatg gcccagggaa gagtccaata     1380

ccaggtccag gcacagggct aaacatcaga ctaatcccag gtccaggccc agatccaagc     1440

aagaagccta tgttgattcc tggtctggat ctgaggatga ggccagcaac ccattctcct     1500

tctgggttgg agaaaatacc aataacttgt tcaggcccag agtcagggag gaggcaaata     1560

tcaggtccaa gctcaggaca aatagagaag attgttttga atctgagtct gaagatgagt     1620

tctataagca gtcctgggtt ttgcctggag aagaggccaa tagtagattc aggcacagag     1680

acaaagaaga tcctaatact gccttgaaac tcagggccca gaaagatgtt gacagtgata     1740

gggtcaaaca agaacccagg tttgaggagg aagtcattat tgggtcctgg ttctgggcag     1800

aaaaagaggc cagtttggag ggtggagctt cagcaatctg tgaatctgag ccaggaactg     1860

aggagggggc cattggcgga tccgcgtact gggctgagga aaagtccagt ttgggggctg     1920

tggccagaga agaggccaag ccggagtctg aagaagaggc catatttggg tcctggttct     1980

gggacagaga tgaggcctgc tttgacctaa atccctgtcc tgtgtacaag gtcagtgata     2040

ggttcagaga tgcagctgag gagcttaatg catcctccag gccccaaacc tgggacgagg     2100

tcactgttga attcaaacct ggtctttttc atggggttgg cttccgatcc acaagcccct     2160

ttggaattcc cgaagaggct tctgaaatgc ttgaggcaaa gcccaagaac ctggaactta     2220

gcccagaagg agaagagcag gaatctttgc ttcagcctga tcagcctagt cctgagttca     2280

catttcagta tgatccttcc taccggtcag tccgggaaat tcgagagcat cttagggcca     2340

gggagagtgc agagtctgag agttggtcct gcagctgcat acaatgtgag ctgaaaattg     2400

gttctgaaga gtttgaagaa ttccttttat taatggacaa aattcgggat ccttttattc     2460

atgaaatatc taaaattgca atgggtatga gaagtgcttc tcaatttacc cgagatttca     2520

ttcgagattc aggtgttgtc tcacttattg aaaccttgct taattatcca tcctctagag     2580

ttaggacaag ttttttggaa aatatgattc acatggctcc accttatcca aatctaaaca     2640

tgattgagac attcatatgt caagtgtgtg aggaaaccct tgcacatagt gtggattccc     2700

ttgagcagct gactggaata aggatgctta gacacctcac tatgactatt gactatcaca     2760

cactgattgc caactatatg tccgggtttc tctccttatt aaccacagcc aatgcgagaa     2820

cgaagtttca cgttctgaaa atgctattga atttgtctga aaatcctgct gtggcaaaaa     2880

aactattcag tgccaaagct ctttcaatat ttgtgggtct ctttaacata gaagagacaa     2940

atgataatat tcaaattgtt attaaaatgt ttcagaatat cagtaacatt ataaaaagtg     3000

gaaagatgtc cttaattgat gatgatttca gtcttgagcc gcttatttct gcatttcgtg     3060

aatttgagga gttagctaag caactacaag cccaaataga caaccaaaat gatcctgagg     3120

tgggacaaca aagttaatat gattaaccac ctgccgctga tcagccttat gttcccaaag     3180

agccctgagt agtgctttgg tgttcacagt ctgttttttt gttgtaactt atatttttta     3240

atgctgatgt taactttgtc aaactcttgt tttgagctgg atcattttgt ggatgccaaa     3300

tgaatatcaa aactgaaaac acatttgttg atatttgtct tgctgtccag attgcggtat     3360

ttttcagtat taagttttca atgaactgtg tcacctaagt aagctaccct gctattcgtt     3420

gtttaaatat atggttctct atttgagtct gtgttttcaa taaagttcta tgttaaaatt     3480

ggca                                                                  3484


<210> 1044
<211> 3504
<212> DNA
<213> Homo sapiens

<400> 1044
tgctgcctca gcctcccgag tagctgggac tacaggtgcc cgccaccacg cccggctaat       60

tttttgtatt tttagtagag atagggtttc actgtgttag ccaggatggt ctccatctcc      120

tgacctcatg atctacccgc ctcagcctgc caaagtgctg ggattacagg cgtgagccac      180

cgcgcccggc caaagcggtt tttaaaggga ggatttggaa ggcaaaagag gcagggggac      240

tgggaggtgt caggtggtgt gaccccctcc agtggcttgt cctgaattat ttttccatct      300

gtggaagtgg ccggcgtcat catggctgga ggaggtgcat ggttcgtatc aggatctgac      360

tactgaagct tctaaggaaa tatgtgacca gataaggtca tcaccttcag gaccacaatg      420

cctggtaggg caaggactcg cgcccgaggc agagcccgcc gcagggagag ctaccaacaa      480

gaggcacctg ggggacccag agcacctgga tcagctacaa cccaggagcc ccctcagttg      540

cagtcgacac cccggccgct gcaggaggaa gtcccagtgg ttagacctct gcagccaaga      600

gcagcaagag gaggagcagg aggaggagca cagtctcaag gggtgaagga acctggacct      660

gaggctgggt tgcatacagc gcccttgcag gagagaagga ttggtggagt ttttcaagac      720

ctggtggtga acaccaggca agatatgaag catgttaaag actcaaaaac aggttcagag      780

ggtacagtgg tacagctact cgccaaccac ttccgagtga tatctcgtcc tcagtgggtt      840

gcatataaat acaacgttga ctacaaacca gacatagaag atggaaatct ccgtacaatt      900

ttacttgatc aacatagaag gaaatttgga gagcgccata tatttgatgg aaactcttta      960

ttattatctc ggccactaaa agagcggaga gtggaatggt tgagcacaac caaagacaaa     1020

aacatcgtga agattacagt tgagttttcc aaagaactca cgcccacgtc gccagattgc     1080

ctacgctatt acaacattct ctttagaaga actttcaagc tgctggattt tgaacaagtt     1140

ggtcgcaact attataccaa aaagaaggcc attcagttat accgtcatgg taccagtttg     1200

gaaatctggc ttggttatgt tacttctgtt cttcaatacg aaaacagcat taccctctgt     1260

gccgatgtga gccacaaact gctccgaata gaaactgctt atgatttcat aaagagaaca     1320

tctgcccagg cccagacagg aaacatccga gaggaagtaa ctaataaatt aattggatca     1380

attgttctga caaaatacaa caacaaaacc tacagagtag atgatattga ttggaagcag     1440

aatcctgaag acacatttaa caaatcagat ggcagcaaaa tcacctatat agactactac     1500

aggcagcaac ataaagaaat tgtcacagtg aagaaacagc cacttttggt cagccagggc     1560

agatggaaaa agggcctaac gggtacacaa cgtgaaccta tcctgctgat tcctcagctg     1620

tgccacatga caggtctaac agatgaaata tgtaaagatt atagcattgt gaaagaattg     1680

gctaaacata caagattgag tccaagaaga aggcatcata cattaaaaga attcatcaat     1740

actctacaag ataataaaaa agtacgagag ttacttcaac tctgggattt gaaatttgat     1800

accaattttt tgtccgtccc gggaagagtt ttgaaaaacg caaacatcgt gcaaggcaga     1860

agaatggtta aagccaattc acaaggagac tggtcaagag aaataagaga attaccctta     1920

cttaatgcaa tgccactaca tagttggctc atactctata gcaggagcag tcacagagaa     1980

gccatgtcct taaagggtca tctacagagt gtcacagccc ccatgggcat aactatgaaa     2040

ccagcagaaa tgattgaagt agatggtgat gctaactcct atatagacac attacggaaa     2100

tatactagac caacactgca gatgggaatg tcatgtttgc tggttttcaa ggtgatttgt     2160

atcctgccca atgatgacaa acgtagatat gacagcataa aaagatacct atgtaccaaa     2220

tgcccaattc caagccagtg tgtggtgaaa aagaccttag aaaaagtcca ggcaaggacc     2280

atcgtcacca agattgccca gcagatgaat tgcaagatgg gaggagccct ctggaaggtg     2340

gagacagacg tacaaagaac aatgttcgtt ggcattgatt gtttccacga tatcgtaaat     2400

cgacagaaat caatagcagg atttgttgca agtaccaatg ctgaattaac aaagtggtac     2460

tctcaatgtg tcatccagaa aacaggagaa gagcttgtga aagagctgga gatctgcttg     2520

aaagctgccc tggatgtctg gtgtaaaaac gaatcatcga tgccacattc tgttattgtg     2580

tatcgggatg gagtgggaga tggtcagctt caagcattgc ttgaccatga agcgaaaaag     2640

atgtcgacct acttaaaaac catctctcct aacaatttca ctctagcttt cattgtggtg     2700

aagaaacgaa taaacactag attttttctt aaacatggaa gcaattttca aaatccacct     2760

ccaggaacag ttattgatgt agagttgact aggaatgaat ggtatgactt ttttattgtg     2820

agtcagtctg tgcaagatgg gactgttacc cccactcatt ataacgtcat ctatgacacg     2880

attggcttga gcccagatac agtacagcgt ttaacatatt gtctatgcca catgtattat     2940

aatttgccag gcatcatccg agttccagcg ccttgccact atgcccacaa gctggcttac     3000

ctcgtggggc agtccattca ccaggaaccg aatcgttcct tgtcaactcg tctcttttac     3060

ctttgacctg cagaagaaga cctgatgtgc taatgaaacc acaacgtgta agcctgtctt     3120

ccttttgaag caggatgtct gaaatatttt cctaggtcca tagcattaaa ttctcatcgt     3180

ttttgattgg acacaggaga gattcagagt gatatgttct actctcaata ctaccacaga     3240

ctgatttttc cagagaggag aactgacagg gtttggcttg cagtttccct ttcaaatatg     3300

tgacagagat ctcacagctg aacgtgactg aacattttcc accccaagca gggccactct     3360

aagaattgaa aagatggggc attcgtcaca gagagagtac atctgtgaac aagtaaactc     3420

tacttggaaa actacgttta ctttattttt gaaacttttt tttgttaaag gacaggaaag     3480

gaagacataa aagtaacaac actg                                            3504


<210> 1045
<211> 2529
<212> DNA
<213> Homo sapiens

<400> 1045
atccctctca gctcttgcta agtgatcact agcttgcctc caagctctct cactatgaac       60

agacaagttt gcaagaaatc cttcagtggc aggagccagg gtttctctgg ccgctctgct      120

gtggtctccg gcagcagcag gatgagctgt gtggcccgct ctgggggagc tggtggaggg      180

gcctgtggct tcaggagcgg agcaggcagc tttggcagtc gcagcctcta caacctgggc      240

agcaacaaga gcatctccat cagcgtggca gctggcagct cccgggctgg aggctttggg      300

ggagggcgga gcagctgtgg ctttgcaggt ggctatggag gtggctttgg gggcagctat      360

ggtggtggct ttggtggtgg cagaggagta ggtagtggtt ttggaggggc tggtggcttt      420

ggtggagctg gtggctttgg tggtcctggt gtatttggtg ggcctggcag ctttggtggt      480

cctggtggct ttggccctgg gggctttcct gggggaattc aggaagtgat tgtaaaccag      540

agtctcctgc agcccctcaa tgtggagatc gacccccaga ttgggcaagt aaaggcccag      600

gagcgggaac agatcaagac cctcaacaac aagtttgcct ccttcatcga caaggtgcgg      660

ttcctggaac agcagaacaa ggtcctggag accaagtggg aactgctcca gcagcagacc      720

acaggctcag ggcccagcag cctggagcct tgttttgaat cctacatcag cttcctatgc      780

aagcagctag attcacttct aggggagagg gggaacctgg agggagagct gaaaagcatg      840

caggacctgg tggaagactt caaaaagaag tatgaagatg aaatcaacaa acgcactgcc      900

gcagagaatg agtttgtggg gctcaagaag gatgtggatg cggctttcat gaacaaggtg      960

gagctgcagg ccaaagtgga cagcctgaca gatgaagtca gcttcctgag gaccctctat     1020

gagatggagc tgtcccagat gcaaagccat gccagtgaca cgtctgtggt tctgtccatg     1080

gacaacaacc gctgcctgga cctgggcagc atcattgccg aggtccgcgc ccagtatgag     1140

gagattgccc agaggagcaa gtctgaagct gaggccctgt accagaccaa gcttggggag     1200

ctgcagacca cagctggcag gcatggggat gacctgagga acaccaagag tgagatcatg     1260

gagctcaaca ggatgatcca gaggctacgg gctgagattg aaaatgtcaa gaagcagaat     1320

gccaacctgc agacggcaat tgcagaggct gagcagcgtg gagagatggc cctcaaggac     1380

gccaatgcca agctccaaga cttgcagact gccctacaga aggctaagga tgacctggct     1440

cggctcctgc gtgactacca ggagctgatg aacgtcaagc tggccctgga tgtggagatt     1500

gccacctacc gcaagctgct ggagggagag gagtgcagga tgtctggaga atgtcagagt     1560

gccgtgtgca tttcagtggt cagcaatgtc accagcacaa gtggcagctc tggcagtagc     1620

cgtggagttt ttggaggggt cagtggcagt ggcagtggtg gctacaaagg cggcagcagc     1680

agcagcagca gcagtggcta tggagtcagt ggcggcagcg gcagtggcta tggaggggtc     1740

agcagtggca gcactggggg caggggtagc agcgggagct accagagcag cagtagtggg     1800

agcaggctcg gcggtgcagg tagcatctcc gtgagccaca gtggaatggg ctccagctct     1860

ggcagcatcc agacttctgg aggaagtggc tacaagtctg gtggtggagg cagcaccagt     1920

atccgcttct cccagaccac gagctcaagc cagcatagct ccaccaagtg atctactgtt     1980

ccaaatctct ataaccacct gcttcccact cagcctgcaa tagtgtttcc cactctctgc     2040

ttggcatcaa tagatgcata agggtcaacc acatttttcc tcaagttccc tggagaagaa     2100

gctgaactcc tggtttctcc atccccatga ccttcccagg gccatggagg tcctgctgct     2160

ggtctgggat gatgatgccc ctggaaacct tcctgcaatg gccccttact ttggacagca     2220

acccctgagc ccaagccagt tttggccttc acagcctggc ctgttcccac tctggcccat     2280

ctccctttct tactgggagt tggagatttg aagccagtca tctcagcact gtctgaggag     2340

ggcagagcca tgggttctgt gctggagggt gcacggccaa gatctccaga ctgctggttc     2400

ccagggaacc ctccctacat ctgggcttca gatcctgact cccttctgtc ccctaattcc     2460

ctgagctgta gatcctctgg tgatgagtat gttgcacttt cttttctcaa taaattgcac     2520

tgaacttca                                                             2529


<210> 1046
<211> 4785
<212> DNA
<213> Homo sapiens

<400> 1046
acctgcttcc ctctcggata gccagggctg atgatttcaa ctcattaatc attccgaact       60

cttcccaaca aacagcctca tggctgtccc ggacctcctc tgtcccggct caggaaatga      120

tctcggtcgg aagtgaaaag accaaatcgg ccccaggagg ccattttctt cgacagaagc      180

tgaggcgtgg gggcgtggcc ttcccccgct tccccctcca ctcccccgcc cgcccccggc      240

cccggctttc cgatctcggc ccagggaaga gccttggtcg cgaatcacca gtttgcattt      300

gcccctgggg cgggggcggc tttctgagac caggctgggg ctgggactcc gccaccttca      360

gctaagggta ccgaggtcag tccgggagtc gcgtcaccgg gactcgaacc cgcctcttcg      420

tcttccgagg cctagtgcga gcctgcggcg ctaaacgcag tcacactgtc cctttaaggc      480

ggcacttttt attcttcatt tgtttacttc ttcatgcgct cttcggtctt tacaaaatgt      540

gctcgcgata tccttccgca agtgtcagtc tcaggcactc accacccgcc ttgaagccat      600

ttctataatc ttaagactcg cgagttagca gccgtgggcc gacgtctctc tttataggat      660

ttaattcttt tacattttag ggactacttt ttaggaataa accattcttg cgttagttaa      720

taaaggttca taaccttcgg aacccctccg ctgagaacaa aatacgataa tagcctttat      780

aacgcacctt ttcataaaaa tattctgtga ggactctcat aggccatcga atcttctcgt      840

attcctgaaa cagaatggta cggtccagaa cccgccccat cttctctgcg attggccgtc      900

cttcctcagc gagtcgtgtg atttttcacc aatggccgct cgcgtttctt tagcgaggtc      960

taagcgatgg aaggtggcgg ccagggagac gccccctacg cgtcctggga ttggctacgt     1020

cgcacggcgc gcgagggcgg cgggcccgaa agataagaac tacgactccc ggcgccccgc     1080

aaagggaact ccgttacgca tgcgcacggg cggggcgaaa aagcttctat ataaaagggg     1140

cgcagaggac tgggagacag cagttggaag ttggcaggtg gagaggcagg ttgggaggga     1200

aagtcggggg aggacgcgga agaggagctg tgggaagggg gaggagggag ggaggaaaag     1260

aggaggaggc ggaggagaac tgagcagagc agagcatcga gccaaagggg agatgagttt     1320

gtctgtcctc tgctgaggct acggccgggc ctagggaact gggagcttgg gtggaagcga     1380

cacccgtgga agtgggagga ggtggcgccg ggactttaac cccttgtggg ctctgcggca     1440

ggggatttaa ccctttgtgg atctggcccc tcggaggcag cgtcatcggt agttttaacc     1500

ccttcggggc tgggtttcac gcactggact taccctcatc accttgctca ccaactcctt     1560

tattggggtg ctccgcttgg aggtttgagg cccacctccg cccattacgt actgttcctg     1620

ccgctgcacc cccttggacc cgctagctgg ccgcactgtg ggcgcttaac cctttactga     1680

cttgagctcc ccagattgca gttggagttt gctgatagaa ggactagcta aaggcgtcac     1740

tgcaggaatt acaaactgaa gaggactctg ttggactgtt ttttttttct ttttcttttt     1800

tttaagaaaa acccattttt ttccttaagg acttactagc caaaatttct taaacttcga     1860

ggactctact agccatggcc gagccattct tgtcagaata tcaacaccag cctcaaacta     1920

gcaactgtac aggtgctgct gctgtccagg aagagctgaa ccctgagcgc cccccaggcg     1980

cggaggagcg ggtgcccgag gaggacagta ggtggcaatc gagagcgttc ccccagttgg     2040

gtggccgtcc ggggccggag ggggaaggga gcctggaatc ccaaccacct cccttgcaga     2100

cccaggcctg tccagaatct agctgcctga gagagggcga gaagggccag aatggggacg     2160

actcgtccgc tggcggcgac ttcccgccgc cggcagaagt ggaaccgacg cccgaggccg     2220

agctgctcgc ccagccttgt catgactccg aggccagtaa gttgggggct cctgccgcag     2280

ggggcgaaga ggagtgggga cagcagcaga gacagctggg gaagaaaaaa cataggagac     2340

gcccgtccaa gaagaagcgg cattggaaac cgtactacaa gctgacctgg gaagagaaga     2400

aaaagttcga cgagaaacag agccttcgag cttcaaggat ccgagccgag atgttcgcca     2460

agggccagcc ggtcgcgccc tataacacca cgcagttcct catggatgat cacgaccagg     2520

aggagccgga tctcaaaacc ggcctgtact ccaagcgggc cgccgccaaa tccgacgaca     2580

ccagcgatga cgacttcatg gaagaagggg gtgaggagga tgggggcagc gatgggatgg     2640

gaggggacgg cagcgagttt ctgcagcggg acttctcgga gacgtacgag cggtaccaca     2700

cggagagcct gcagaacatg agcaagcagg agctcatcaa ggagtacctg gaactggaga     2760

agtgcctctc gcgcatggag gacgagaaca accggctgcg gctggagagc aagcggctgg     2820

gtggcgacga cgcgcgtgtg cgggagctgg agctggagct ggaccggctg cgcgccgaga     2880

acctccagct gctgaccgag aacgaactgc accggcagca ggagcgagcg ccgctttcca     2940

agtttggaga ctagactgaa acttttttgg gggagggggc aaaggggact ttttacagtg     3000

atggaatgta acattatata catgtgtata taagacagtg gaccttttta tgacacataa     3060

tcagaagaga aatccccctg gctttggttt cgtaaattta gctatatgta gcttgcgtgc     3120

tttctcctgt tcttttaatt atgtgaaact gaagagttgc ttttcttgtt ttccttttta     3180

gaagtttttt tccttaatgt gaaagtaatt tgaccaagtt ataatgcatt tttgttttta     3240

acaaatcccc tccttaaacg gagctataag gtggccaaat ctgagaacaa ttaaattcat     3300

tttagttata ataaatttaa tatttgtaaa tgtaacatag tttcagtgtg atttctagag     3360

ctaattcaaa atagtattga tatattttat gtgactgcat ttttggggag gggtaccgaa     3420

atcgttaaat ttgtcagttt gcaaaaatat caatctttaa tgggagaatt ttcaatttgc     3480

caattttttc cttgaatggg tttaagtatg ctacaatata cagttcaggc aaaatttaag     3540

atgtaattat cttcaatact taagtgtgct tgctttctag tgccttggtt ttctttcttg     3600

atgctggaaa aataaacaaa ccggtattga gtgtttaggc gagtggaaag tggctacaat     3660

ccaaaatttt aaatttaact ctgcctcggc cattcaaaag tctaataaca aaaaatgtaa     3720

acctaatttg gcagtttgtt aggttagaca actgacagcc tcatttcatt cctacaagtt     3780

ggttttcagt aatctcttcc ttccccccag taaggctgga agaggctctt ggcaaacttc     3840

ttagtgcaag caatggttag attaatttgt gaggcagctc tttaagacgt tcagaggtaa     3900

gaaatactgg atttataaag caaatggctg tttgggggat tccaaggatt tacctaattg     3960

tccaattcta cgtgctctct ataccaaaac aaaaaaaaaa agctatccac ctttccatgt     4020

gggtcaaact aaaattagaa atgtcccctc actgcagatc aaatgtaaag cttccagtta     4080

aggagctaaa tgaggtcctc agctgaatga ggaaccctgt acatcccctt gcacagccct     4140

attctaaatc gcttaaacta tgctgatagc tgcttaggtt cttgagtagt tctgctctta     4200

aacgtaggga ggccctgaga actaaatttt gccccaaaat aaaaacagaa attatgagat     4260

tgcctcctgt cattttggtt aacccagtcc ttcacctgcc ctgtgtcagt gtcttctgag     4320

ggcaattgcg ttgctcaaat cactagcaca gaggttcctt aatttggggc cttagaaacc     4380

attgtgggcc ttggggtcca tgaaccccat gaaattattt gtagacttgt atgtacattt     4440

ttctggggag aaggttcaag agattcataa gattgtcaaa ctccttgaag gttcagaacc     4500

tctgcaggga agggggaaga aaaccctccc attaggaagc atgcttttgc agttaaatgg     4560

cgatggtgga ggtgataggg acttcaagag taaaatgcac cttgtattgc ataagaagca     4620

tacacaaatc aataaatcaa gggagattat accagtagga ctgaatcagg gccttcaaag     4680

ctggactgag ttggtcctgt tctggcacat atggtccact ggagacaatg tatgattgag     4740

tttttctttg gtctaaaaat tatattaaac atttattttg aaata                     4785


<210> 1047
<211> 6414
<212> DNA
<213> Homo sapiens

<400> 1047
gagttgtagg cctccggcgt cagcccgcgg gctgccgccc gcactctcca agagactgct       60

ggcgccggcg cccgcccgcg cggcaccgac gcggggagcg cgcttcgcgc tgactcagcg      120

gcggcggcgg ctgcggcggc ggcggcggcg ttagccggcc ctcgcgctct ttcccttcct      180

ggggcgccga ccccgcccgc ttgcttgctt gcttgcttgc ctgcctgcct gcctgcccgg      240

cgccacgcaa gagaaggtgc caggggacgc agagcgacta gaggcgcgcg gtcccggcca      300

gcaccgtctc tggcgttgta gctgcggccg tggcggagga ctacggcgac aaggacgagg      360

gccgctctcc cagctctctg cgtgccgcgc cgctccgctc cgctggctga ccatctggag      420

tgcaggctgg gaggcgggat ggagtgatag ggaagatgtt tataaattct tctgtgggat      480

cagagggcac gcctattaca accagaaaac tacaagtata acagcgagga tggatgaaca      540

ggctctatta gggctaaatc caaatgctga ttcagacttt agacaaaggg ccctggccta      600

ttttgagcag ttaaaaattt ccccagatgc ctggcaggtg tgtgcagaag ctctagccca      660

gaggacatac agtgatgatc atgtgaagtt tttctgcttt caagtactgg aacatcaagt      720

taaatacaaa tactcagaac taaccactgt tcaacaacag ctaattaggg agacgctcat      780

atcatggctg caagctcaga tgctgaatcc ccaaccagag aagaccttta tacgaaataa      840

agccgcccaa gtcttcgcct tgctttttgt tacagagtat ctcactaagt ggcccaagtt      900

tttttttgac attctctcag tagtggacct aaatccaagg ggagtagatc tctacctgcg      960

aatcctcatg gctattgatt cagagttggt ggatcgtgat gtggtgcata catcagagga     1020

ggctcgtagg aatactctca taaaagatac catgagggaa cagtgcattc caaatctggt     1080

ggaatcatgg taccaaatat tacaaaatta tcagtttact aattctgaag tgacgtgtca     1140

gtgccttgaa gtagttgggg cttatgtctc ttggatagac ttatccctta tagccaatga     1200

taggtttata aatatgctgc taggtcatat gtcaatagaa gttctacggg aagaagcatg     1260

tgactgttta tttgaagttg taaataaagg aatggaccct gttgataaaa tgaaactagt     1320

ggaatctttg tgtcaagtat tacagtctgc tgggtttttc agcattgacc aggaagaaga     1380

tgttgacttc ctggccagat tttctaagtt ggtaaatgga atgggacagt cattgatagt     1440

tagttggagt aaattaatta agaatgggga tattaagaat gctcaagagg cactacaagc     1500

tattgaaaca aaagtggcac tgatgttgca gctactaatt catgaggatg atgatatttc     1560

ttctaatatt attggatttt gttacgatta tcttcatatt ttgaaacagc ttacagtgct     1620

ctcggatcag caaaaagcta atgtagaggc aatcatgttg gccgttatga aaaaattgac     1680

ttacgatgaa gaatataact ttgaaaatga gggtgaagat gaagccatgt ttgtagaata     1740

tagaaaacaa ctgaagttac tgttggacag gcttgctcaa gtttcaccag agttactact     1800

ggcctctgtt cgcagagttt ttagttctac actgcagaat tggcagacta cacggtttat     1860

ggaagttgaa gtagcaataa gattgctgta tatgttggca gaagctcttc cagtatctca     1920

tggtgctcac ttctcaggtg atgtttcaaa agctagtgct ttgcaggata tgatgcgaac     1980

tctggtaaca tcaggagtca gttcctatca gcatacatct gtgacattgg agttcttcga     2040

aactgttgtt agatatgaaa agtttttcac agttgaacct cagcacattc catgtgtact     2100

aatggctttc ttagatcaca gaggtctgcg gcattccagt gcaaaagttc ggagcaggac     2160

ggcttacctg ttttctagat ttgtcaaatc tctcaataag caaatgaatc ctttcattga     2220

ggatattttg aatagaatac aagatttatt agagctttct ccacctgaga atggccacca     2280

gtccttactg agcagcgatg atcaactttt tatttatgag acagctggag tgctgattgt     2340

taatagtgaa tatccggcag aaaggaaaca agccttaatg aggaatctgt tgactccact     2400

aatggagaag tttaaaattc tgttagaaaa gttgatgctg gcacaagatg aagaaaggca     2460

agcctctcta gcagactgtc ttaaccatgc tgttggattt gcaagtcgaa ccagtaaagc     2520

tttcagcaac aaacagactg tgaaacaatg tggctgttcc gaagtttatc tggactgttt     2580

acagacattc ttgccagccc tcagttgtcc cttacaaaag gatattctca gaagtggagt     2640

ccgtactttc cttcatcgaa tgattatttg cctggaggaa gaagttcttc cgttcattcc     2700

atctgcttca gaacatatgc tcaaagattg tgaagcaaaa gatctccagg agttcattcc     2760

tcttatcaac cagattacgg ccaaattcaa gatacaggta tccccgtttt tacaacagat     2820

gttcatgccc ctgcttcatg caatttttga agtgctgctc cggccagcag aagaaaatga     2880

ccagtctgct gctttagaga agcagatgtt gcggaggagt tactttgctt tcctgcaaac     2940

agtcacaggc agtgggatga gcgaagttat agcaaatcaa ggtgcagaga atgtagaaag     3000

agtgttggtt actgttatcc aaggagcagt tgaatatcca gatccaattg cacagaaaac     3060

atgttttatc atcctctcaa agttggtaga actctgggga ggtaaagatg gaccagtggg     3120

atttgctgat tttgtttata agcacattgt ccccgcatgt ttcctagcac ctttaaaaca     3180

aacctttgac ctggcagatg cacaaacagt attggcttta tctgagtgtg cagtgacact     3240

gaaaacaatt catctcaaac ggggcccaga atgtgttcag tatcttcaac aagaatacct     3300

gccctccttg caagtagctc cagaaataat tcaggagttt tgtcaagcgc ttcagcagcc     3360

tgatgctaaa gtttttaaaa attacttaaa ggtgttcttc cagagagcaa agccctgagg     3420

actggatttc cctgtgccta cttcatgatc atgaattcca gttaatttat aaagaggcga     3480

tttttgtgtg ccattcacac tggtcttttt cacattgttt tgagcttatt gcagtatatg     3540

ttttgggatt tttctgtaaa atgggtgtaa ttttcctaat acaggtatgt aacaacaaaa     3600

gaagttgcct gcatgccggt ccaaattgtt ctgtataaag atgctcttaa aagacacaag     3660

agttatccta gaaccttaat tcttttttat ttgaaatttt aagtcaagtc ctttataaag     3720

accatagcag tggaaaacag tgtacttttt aaaaaattgc tgaatataaa atctttgaaa     3780

attttcttta tgtgtgaaga cacaaagtat gggggaagac agcaatcaaa actaactttt     3840

tgtagatagc catttcattt ctttaaactg tttcaacgcc aatatgtatt ctacaaaaga     3900

gaatggtttt aggctccagt gttatacttt tttttatata tatatataaa aataaacttt     3960

acgtagtgaa atcttccaag tcttttctgg aattattata aatactttag ttttattttc     4020

tcatcttaat ctctccataa tttcccattt aaaggtttac aaatatgagt gtgtggatgc     4080

tttaattcat ttaacctcac tcctcaaagg taacatgcaa cttagttctg ttatatgaga     4140

gtctttttct ttaatgtact ggaaaaagcc tatgtgaatc tgttgataga atttaaaatt     4200

ccaggccggg cgtggtggct cacgactgta atcccagaac tttgggaggc caaggcaggt     4260

ggatcacttg aggtcaggag ttcgagacta gcctggccaa catggtgaaa ccccatctct     4320

actaaaaata caacagccag gtgtgatggt gcacgctcgt aatcccggct actcaggagg     4380

ctgaggcagg agaatcgctt gaacccggaa ggcagaggtt gcagtgagct gagattgtgc     4440

cactgcacgc cagcctgggc aagagagtaa gactctctct caaaaaaaaa aaaaaagaat     4500

ttaaaatccc aatttatttt ctaactcttt tattggatgt atttagaaca cagtatacct     4560

atagtatacc tatgtgttta ttatgtttgt aaatggtaac tgacatttaa ttattagaag     4620

tacttacccc tgccttcctc catttttatt catggctact tgagaaagca aaaggaaaaa     4680

ataatagtta tcagtagtgt cactggaaag aagagaggag ggacaaaact gagcagcaga     4740

attcgtatag acatttacgt ttaaattcta aaagcccaat tgagatgttc agggagggtt     4800

tgttttgccc tttggcctca tgaatgggtt tcatgaatgg gcttcagtgg cttataaact     4860

ctgtaaaatt ctattctaaa ttttgtacat ttattttgtt ccggttaatt ccagaagaca     4920

tttcaaacat ttttcttaca ccatataata aaaatactta actaaattga cagttataaa     4980

aataaatcag tgaaatgtac cttatacttt aataaaaaat gttttcagaa atagataagt     5040

gaaagctgag tgtttctttg ataggttccc ctgtactata ggagtgataa ttgcagctat     5100

tgcaatagta gtaattgtta aatggatact aatgaatagc atagcatagt gggtaagagt     5160

ttatatagca caggctctag aatcagatta agtaggttca aataccagtt ctgccagtaa     5220

ctggttttag aaccttgggc aagttaaaga atgtctccca gcctcagttt ccctatttgt     5280

aaaatggaaa taatggtagc tacctcaaac ctcattacga attcaatgag ttaaacttga     5340

aaagacttat tacagtagct ggcacataaa gacttgatag tagtttatat ggatgctatc     5400

tcatattagc atatatggaa ttaatagtgt atcactatac tttttttttc tttttttttt     5460

ttgaatagag atcagtctat cacccaggct ggagtgcagt ggtgacatca tagctcactg     5520

taacttctcc catactctac caatcctcct gcctcagcat ccagactagc tgtgattaca     5580

ggtgtgcacc accacaccca gctacatttt tttttggtag agacagggtc tcactatgtt     5640

acccagtctg gtctcaaact cccggcctca agcaatcctc ccactggcct cacaatgttg     5700

ggattacagg tataagccac tgcacacggc cttactatgc tatcaattcc atatatggaa     5760

aggtgttttc cctttcagag ctctttaaag ctctgcagaa gatttacatg tgtttataga     5820

gctaagagaa atcagggcat ggaaattgag tgtgtaataa aaattaaact cttcatgtta     5880

tataatcatg cataacttct atcttcattc tctgaagttg cctagagcac catcacagct     5940

aggaagcttc catcatgaat taccttattt ccaaaagcaa gtactcaaat aattgtctca     6000

agagaggaag gacaaaactg ttacaagctg aaatatttgg ggatttgttt gacttgacta     6060

gggaaccaca agttttcata taatgcctga tttagccctg tgcctaacag tttaaatctt     6120

aatgctaatg ttaattgctt cccagttggt tgaccttata agaaaacact gtgtggtatt     6180

ttaatgtggt aaacatgtga atgaaggcct gtggctcagt taatcactcc cacaactttg     6240

agctgtgagt tttactggtg gaaggaactt taacaggtct tcgctcttgt cattagatat     6300

caaagaactg aaattagttg gaattgtaag cagtgaatag atgtgttgtt agaatgattc     6360

catcacttat acattgttta aaatgctaat aaagtaactt gctttgtaag aatt           6414


<210> 1048
<211> 3484
<212> DNA
<213> Homo sapiens

<400> 1048
acacctcagt tcacaatcct ggggcgatat ggcagaatct tttttttcgg attttggctt       60

gttgtggtat ctgaaggagc tcagaaagga agagttttgg aaatttaagg agctcctcaa      120

acaacctttg gagaaatttg aactcaagcc aatcccctgg gctgagctga agaaggcctc      180

caaagaagat gtagcaaagc tgctggacaa acattaccca ggaaagcagg catgggaggt      240

aacactgaac ctgtttctac agatcaatag gaaagatctc tggacaaagg ctcaggaaga      300

gatgagaaat aagctaaacc catacagaaa gcatatgaag gaaacatttc aactcatatg      360

ggagaaggaa acctgtcttc acgtccctga gcatttctac aaagaaacca tgaaaaatga      420

gtataaagaa ttgaatgacg catatactgc tgcggctaga cgacacactg tggtcctgga      480

aggtcctgat ggaattggaa aaacaaccct tttaagaaaa gtgatgttgg actgggcaga      540

gggaaactta tggaaggaca ggttcacatt tgtgtttttc ctcaatgtct gtgaaatgaa      600

cggtatcgca gagaccagct tactggagct cctctctagg gactggccgg agtcttcaga      660

gaagatcgaa gacatttttt cccagccaga gagaattctg ttcatcatgg atggctttga      720

gcaactgaag tttaacttac aacttaaggc tgacttgagc gatgattgga ggcagcggca      780

gccaatgcca attatcctga gcagtttgtt gcaaaaaaag atgcttccag aatcctctct      840

ccttattgca ttaggaaaac tggctatgca aaaacactat tttatgttgc ggcatccaaa      900

actcataaag ctcttaggat tcagtgaatc tgaaaagaag tcgtatttct cctacttctt      960

tggtgagaag agcaaagccc tgaaagtctt caattttgtg agagataatg ggccgctgtt     1020

tatcttgtgc cataatccct ttacgtgctg gttggtctgt acttgtgtga aacagaggct     1080

agagagggga gaagaccttg aaataaactc ccaaaacacc acctatttat atgcatcctt     1140

tttaacaact gtattcaaag caggaagtca gagttttcca cctaaggtga acagagcccg     1200

actaaaaagc ctgtgtgctt tggctgcaga gggaatttgg acatatacat ttgtattttc     1260

ccatggggat ctccggagga atgggttatc tgagtctgag ggcgtgatgt gggtgggtat     1320

gagactcctc caaaggagag gggactgttt tgccttcatg catctgtgta tccaagagtt     1380

ttgtgccgcc atgttttatt tgctcaaacg acccaaagac gatcctaacc cggccattgg     1440

aagcataacc cagcttgtaa gagcaagtgt ggttcagcct caaaccctct tgacccaggt     1500

ggggatattc atgtttggaa tttcaacaga agaaatcgtc agcatgctgg agacctcctt     1560

tggttttcca ctgtcaaaag acctaaagca ggaaataacc caatgccttg aaagtttaag     1620

tcaatgtgaa gctgataggg aagccatagc tttccaggaa ctattcattg gtttgtttga     1680

aactcaggaa aaagaatttg taaccaaagt gatgaatttc tttgaagaag ttttcattta     1740

tattggtaac atagaacatt tggtaatagc ttcattctgc ctgaagcatt gtcaacattt     1800

aacgacactt cgcatgtgtg tggagaatat ctttccagat gactcaggat gcatctcaga     1860

ttacaatgag aagctcgtct actggcggga gctttgctca atgttcatta ccaacaagaa     1920

cttccagatt ttagacatgg aaaataccag ccttgatgat ccctccctgg cgattctttg     1980

caaagcgctg gctcagcctg tttgtaaact ccgaaaactc atatttactt ctgtgtactt     2040

tggacatgat tcagaattat ttaaggcagt tcttcacaac cctcatctga aacttctgag     2100

cctgtacggc actagcctct cccagtctga catcagacac ctgtgtgaga cgctgaaaca     2160

tccaatgtgc aagatagaag agctgatact gggaaagtgt gacatctcca gtgaagtttg     2220

tgaagacatc gcctccgtcc tggcctgcaa cagcaagctg aaacacctct ccttggtaga     2280

aaatcccttg agggacgaag gaatgacgtt gctgtgtgaa gccctgaagc actcacactg     2340

tgccctggag aggctgatgt tgatgtactg ctgtctcacc tctgtctcct gtgactccat     2400

ttccgaagtc ctcttgtgca gtaagtccct gtccctcctc gatctgggct caaatgccct     2460

ggaagataat ggagtggcat ctctgtgtgc agcgctgaag cacccaggct gcagcatacg     2520

ggagctgtgg ttgatgggct gtttccttac ttccgattcc tgtaaggaca ttgctgctgt     2580

tcttatttgc aatgggaaac tgaagaccct gaaacttggg cataatgaaa taggagacac     2640

tggtgtcaga cagttatgtg cagctttgca gcatcctcac tgtaaattag agtgtctcgg     2700

gctgcaaacg tgtccgatca cccgtgcctg ctgcgacgac atcgccgcag cactcatcgc     2760

ctgcaaaaca ctgaggagcc tgaacctcga ctggattgcc ttggatgctg atgcagtggt     2820

ggtgctgtgt gaggcattga gccacccgga ctgtgccctg cagatgctgg ggctgcacaa     2880

atctggcttt gatgaagaaa ctcagaagat cctgatgtct gtggaagaaa aaattcccca     2940

tctgaccatt tcacatggac cttggattga cgaggaatac aagatcaggg gtgtgctcct     3000

ctgatgggga acaccctgaa gtagtcgtct cacaaaggct ttccttggcc acagtgggac     3060

cttcacctgg cacctctatc ctgtaattgc acatcatggc agcagggctg tgatttcaga     3120

ggtactccct aagtgttcta gcaatatgat tatggagtgt gattcagtgt acatgctgat     3180

tgtctttgcc tcggtcctat atccccttgt ctttagaaat cccatcctgc cttgtgatat     3240

ttagaagcac aagtacgtta aacaagtgct aaacgctctg gaaagcatgg ctttattttc     3300

ttaatggatg tcttggtgtg taggagcatg catttgtagg caccacaatc cggatacttc     3360

tgacacagaa gtgatgctag aatgtgtcta tagattgtat tgctagcatc cagactttct     3420

agtttgtcca gatttcgatt tgatcaattt tcttgtccaa taaaaaagca tttccaaatc     3480

tcta                                                                  3484


<210> 1049
<211> 868
<212> DNA
<213> Homo sapiens

<400> 1049
gagattccta aatcattgca ggttaattgt gagaggggac cagtcccaga ggctctcagc       60

tctgcagtgc ttccgaatca ctggacgact ctttaagaat tctgatcccc gggcccccat      120

cccggaccaa tgaaatcaga atctctaata gtggggccct ggcatcggta gtttttaaag      180

ctgcccaggt gattctgggg tgccgagaac caccgtgtta agctccacca gcccattgga      240

gaaaagttac tgttcagtcc ctgaaggctt gtgccataaa agagtgggag acattcccag      300

ggagtttcag cacccatttg gactttcaca atcagagatg gcagcggtaa aggcatcaac      360

atcgaaagct accaggcctt ggtattctca tccggtatat gcaagatact ggcaacatta      420

tcatcaagca atggcttgga tgcaaagcca tcacaatgcc tacaggaagg ccgtggaatc      480

ctgtttcaat cttccatggt acttaccttc tgcgcttctt ccccaaagct cttacgataa      540

tgaggctgcg tatcctcagt ccttctatga ccatcatgtg gcctggcagg actacccctg      600

cagttcttca catttcagaa gatctgggca gcatccacgt tacagcagta ggatccaggc      660

atccacaaaa gaagaccaag ctttgtccaa agaggaagag atggagactg agtcagatgc      720

agaggtagaa tgtgacctga gcaatatgga aatcactgaa gagctccgcc agtactttgc      780

agagaccgag aggcatagag aagaacgacg gcggcagcag cagctggatg cagagcgcct      840

ggacagctat gtgaacgctg accacgac                                         868


<210> 1050
<211> 1969
<212> DNA
<213> Homo sapiens

<400> 1050
ggcgtcgtgg ggaggagcgt ggcgtcggcg tcgtggggag gagcgtggcg tcggcgtcgt       60

ggggaggagc gtggcgtcgg cgtcgtgggg aggagcgtgg cgtcggcgtc gtggggagga      120

gcgtggcgtc ggcgtcgtgg ggaggagcgt ggcgtcggca tggtggggag gagctgtggg      180

gtggcaaccc agaggcaagg aggtgggcag aggcccacga acctggccct gaccctcagc      240

tcgtccccag ctcacagcac agccctcccc tggctgcctc caaggagtct ccagttactg      300

agtggccact ccgtgccagc tcagcccacc cctcaccttc ccagtgcctg tggaggccca      360

actagggtga cgctgggaga ggagagggct tggaggagcc acgggtcaaa tgcaggaggc      420

cacacctgcc tgcccaggag gactgcagga gccggatcct taacacctgg aggggagcgg      480

gggggcaaca acgccggcca cacggtggtg gtggatggga aagagtacga cttccacctg      540

ctgcccagcg gcatcatcaa caccaaggcc gtgtccttca ttggcaacgg ggtggtcatc      600

cacttgccag gcttgtttga ggaagcagag aagaatgaaa agaaaggcct gaaggactgg      660

gagaagaggc tcatcatctc tgacagagcc caccttgtgt ttgattttca ccaggctgtc      720

gacggacttc aggaagtgca gcgccaggca caagagggga agaatatagg caccaccaag      780

aagggaatcg gaccaaccta ctcttccaaa gctgcccgga caggcctccg catctgcgac      840

ctcctgtcag attttgatga gttttcctcc agattcaaga acctggccca ccagcaccag      900

tcgatgttcc ccaccctgga aatagacatt gaaggccaac tcaaaaggct caagggcttt      960

gctgagcgga tcagacccat ggtccgagat ggtgtttact ttatgtatga ggcactccac     1020

ggccccccca agaagatcct ggtggagggt gccaacgccg ccctcctcga cattgacttc     1080

gggacctacc cctttgtgac ttcatccaac tgcaccgtgg gcggtgtgtg cacgggcctg     1140

ggcatccccc cgcagaacat aggtgacgtg tatggcgtgg tgaaagccta taccacacgt     1200

gtgggcatcg gggccttccc caccgagcag atcaacgaga ttggaggcct gctgcagacc     1260

cgcggccacg agtggggagt gaccacaggc aggaagaggc gctgcggctg gctcgacctg     1320

atgattctaa gatatgctca catggtcaac ggattcactg cgctggccct gacgaagctg     1380

gacatcctgg acgtactggg tgaggttaaa gtcggtgtct catacaagct gaacgggaaa     1440

aggattccct atttcccagc taaccaggag atgcttcaga aggtcgaagt tgagtatgaa     1500

acgctgcctg ggtggaaagc agacaccaca ggcgccagga ggtgggagga cctgccccca     1560

caggcccaga actacatccg ctttgtggag aatcacgtgg gagtcgcagt caaatgggtt     1620

ggtgttggca agtcaagaga gtcgatgatc cagctgtttt agtcacagac tgagctgatc     1680

ccaacaggcc ctggcagcgt ctggacttgt gtaaacagca gcagtcacgt tcctcggccg     1740

ccacaaccaa caccaaagca ggaaaaccat tttctgtact tttatatttc tgttcaacct     1800

gttggtttct acaatgattt taaacattgg aaagccagcc ttgtgtatat ttttaaaaat     1860

tatattcaaa atgagccaaa gtgctcagag accttctatg acacattagt gtcacatggt     1920

tgcgtgtcca gccgaagcag tgtaataaac atctccaatg gccactgaa                 1969


<210> 1051
<211> 468
<212> DNA
<213> Homo sapiens

<400> 1051
atggtcaact cctgttgtgg ctccgtgtgc tctgaccaag gctgtggcca agacctctgc       60

caggagacct gctgctgccc cagctgctgt cagaccacct gctgcaggac cacctgctac      120

cgccccagct acagtgtgtc ctgctgctgc agaccccagt gctgccagtc tgtgtgctgc      180

cagcccacct gctgtcgccc cagctgctgt gtgcccacct gctgccaccc tagctgctgc      240

atctccagct gctgccgccc cagctgctgt gtgtccagct gctgcaagcc ccagtgctgc      300

cagtctgtgt gctgccagcc caactgctgc cgccccagct gctgccgccc ctgctgctgc      360

ctgcgtccag tctgtggccg agtctcctgc cacaccactt gctatcgccc agcctgtgtc      420

atctccacct gcccccgccc cgtgtgctgc gcctcctctt gctgctga                   468


<210> 1052
<211> 3008
<212> DNA
<213> Homo sapiens

<400> 1052
ccctcgccgc agtcgcgggc accccgctcg gcgtcggtgc ctgagggagg ccgcgatggc       60

ggccgaggcc ctggcggcgg aggccgtggc gtcgcgcctg gagcggcagg aggaggacat      120

ccgctggctg tggtcggagg tcgagcgcct gagggacgag cagctgaacg cgccctacag      180

ctgccaggcg gaggggccgt gcctcacgcg ggaggtggcg cagctccggg ccgagaactg      240

cgacctgcgc caccgcctgt gcagcctgcg gctgtgcctc gccgaggagc ggagccgcca      300

ggccacgctg gagagcgcgg agctagaggc ggcgcaggag gccggcgcac agcctcctcc      360

tagtcaaagc caagacaagg acatgaaaaa gaagaaaatg aaggaaagcg aggctgacag      420

cgaggtgaag catcaaccaa ttttcataaa agaaagattg aagctttttg aaatactgaa      480

gaaagaccat cagctcttac ttgccattta tggaaaaaag ggggatacaa gcaacatcat      540

cacagtaaga gtggctgatg ggcaaacagt gcaaggggaa gtctggaaaa caacgcctta      600

ccaagtggct gctgaaatta gtcaggaact ggctgaaagc acggtaatag ccaaagtcaa      660

tggtgaactg tgggacctgg accgcccatt ggaaggggac tcttctctag agctgcttac      720

atttgataat gagaaagtta acactgcaac taccaccgtg tacaggtgcg gtccattaat      780

tgacctttgc aaaggtccac atgtaagaca cactggaaaa attaaaacca tcaaaatttt      840

taagaattcc tcaacatatt gggagggcaa tccggaaatg gaaacattgc agaggatcta      900

tggaatatcc tttcctgata acaagatgat gagagactgg gaaaagttcc aagaggaagc      960

aaagaaccga gatcacagga agatcgggaa ggaacaagaa cttttctttt tccacgattt     1020

gagtcctgga agctgttttt tccttcccag aggagccttc atttataata cgcttacaga     1080

tttcatacga gaggaatatc acaaacggga cttcacggag gtgctctctc ccaatatgta     1140

caacagtaaa ctctgggaag cctcaggcca ctggcagcat tacagcgaga acatgtttac     1200

ctttgagatt gaaaaggaca cttttgccct caaacccatg aattgtccag ggcactgtct     1260

aatgtttgcc catcgtccac gatcttggag ggaaatgcct attagatttg ctgattttgg     1320

agttctgcat agaaatgaac tgtcggggac tctcagcggc ttgaccagag tgaggcgctt     1380

ccagcaggac gatgctcaca ttttttgcac agtggagcag attgaagaag aaataaaggg     1440

gtgtttgcag tttttgcaat ctgtttactc aacatttggc ttctcctttc aattaaacct     1500

gtcaacaagg ccggaaaact tcctaggaga gattgagatg tggaatgagg ctgagaagca     1560

actgcagaac agcttgatgg actttggaga accgtggaaa atgaacccag gagatggagc     1620

attttatggc cctaaaattg acataaaaat caaggatgct attggcagat accatcaatg     1680

tgctacaatt cagctggact tccaactgcc tattagattt aatctcacat atgttagtaa     1740

ggatggggat gataagaaga gacctgtgat cattcatcga gccattttgg gatcagtgga     1800

aagaatgata gccattcttt cagaaaacta tggcggaaaa tggcctttct ggctatctcc     1860

tcgtcaggtg atggtcatcc ctgtggggcc aacttgtgaa aaatatgcac ttcaggtatc     1920

cagtgaattt tttgaagaag gatttatggc tgacgttgac ttggatcaca gttgtacact     1980

aaataagaaa atacgaaatg cacagctggc tcagtataat tttattttgg tggttggaga     2040

aaaggaaaag atagataatg ctgtaaacgt gcgaacaaga gacaacaaaa ttcatggaga     2100

gattttagta acttctgcca ttgataaact gaagaatctc aggaagacac ggacactcaa     2160

tgctgaggag gccttttgaa gtccttccct gatatttgct tctgtgtaac tttgttttga     2220

cccttaaaaa tgtatttttc ttaacatgtt agtacttcta cgactttgga gccactgatg     2280

ggtccactca tggcctcagc tgagaaagga gacgatgaac gtgtagctga catgcacgaa     2340

gtttaattta ctcatgtcca cgggggacgt ttagagggca cgtgggaaat tttccagcaa     2400

tcaatgcctt gagaaactta aatggggaaa tattattcat cgagaaagtg aaacaaaaca     2460

ctaggaaatg attatgaaat gttagtgatt ttcaaaagat gggcttcaaa taaaagtctg     2520

cagagttttt tttaaatagg agggaaaatc ttattttcta atatgtctca ggtattttta     2580

tgacttctac taaaattcac actgaaactt tatcttctaa actggaatca ttacttaatt     2640

ttaactaacc aacaaccaca aaagcagcag ctactgctaa atattggatt actgacaaag     2700

gaattcagtt ttgtggaatc tggtgtttgc actataggtt aagagttgcc atttaaatgt     2760

ttcttattca taattaggtt ttgttccgct ttagaaaaaa ataaattccc aaatgaattg     2820

catcagtgtt tccagcgttt cagctgtggg cttctaccac cactaagccg ctcacctaga     2880

gttgttactt ttttgatggg atgacattcc atggatttat gtactgaaat ggatttcaga     2940

ttttaaagag aggaatgctc tacgtgctca gaactgaatt aaaatggcat tatgtcaata     3000

gagaattc                                                              3008


<210> 1053
<211> 3686
<212> DNA
<213> Homo sapiens

<400> 1053
agccaagttc tttccatcat cctgggccct cacctctggc ataggctctt ggtagtgggg       60

gcccagacag ggaggcacct gccacctgct tcccttctca gccacccaca gccctcatag      120

ggcagaatgg gactcttgct gatgtagacg ccgaagtcgc gggcgctcat ggcgggcctg      180

gaggtactgt tcgcatcggc agcgccggcc atcacctgca ggcaggacgc gctcgtctgc      240

ttcttgcatt gggaagtggt gacacacggt tacttcggct tgggtgtcgg tgaccagccg      300

ggtcccaatg ataagaagtc agaactgctg ccagctgggt ggaacaacaa taaagacctg      360

tatgtcctcc ggtatgagta taaggatggg tccagaaagc tccttgtgaa agccatcacc      420

gtggagagca gcatgatcct caatgtgctg gaatatggct cacagcaagt ggcagacttg      480

accctgaact tggatgatta tatcgatgca gaacacctgg gtgacttcca caggacctac      540

aagaacagtg aggagcttcg gtctcgtatt gtgtctggaa tcatcacacc tatccatgag      600

cagtgggaaa aggctaatgt aagcagtccc caccgggagt tcccccctgc taccgccaga      660

gaggtggacc cactccggat tcctccacac cacccacaca ccagtcggca gcctccctgg      720

tgtgatcccc tgggcccgtt tgttgtcggg ggagaagact tagacccttt tgggcctcgg      780

agaggtggca tgattgtgga tcccctgaga tctggcttcc caagagcact tattgaccct      840

tcctcaggcc tcccgaaccg acttcctcca ggcgctgtgc ccccaggagc tcgctttgac      900

ccctttggac ccattgggac cagcccaccc ggacctaacc cagaccatct ccccccgccg      960

ggctacgatg acatgtacct gtgaaggcct caagaatgta acatcccagg cttccctcca     1020

ttctcctgga gctgccaccg ctgtccccat cagcaaccat gttcttgcag gctgggggca     1080

agggattctg ctcatgtgtt tgcagaccgg ctgggatagc ctccccaccc cttatcagag     1140

ccaagacacc tgctgcagct ctccacctag ctgcagatag ctcccaaaga gaaatcagtg     1200

tgtctctttc accatcagct cctccccttt caccaccagc tcctctccac ttcccaaggg     1260

agactccggc aaccttcagc aacatatatc ctcgaccaga tgcagtgcta taagaacaga     1320

acgcattttg gatgttatta ttaagaacca aatgtcaata cagaattcat gttgccggtt     1380

tcccactttt ctttttacat taatgcatag ctgcttccat ttatgagact ttagagtttg     1440

agtttctgta gggctgaatg actctttttc ctgcccaggg cccattcttg cttctcaggc     1500

accttccgtt tattaattgc cattgctcct gacatcacta agatgggtcc ccttctggct     1560

gcatgaatgg aaatgagtga ctggaaatcc cataggccac aagaatgact ttcacaaggg     1620

caggaacatt gtggaaagac tgcatcattc tgatgaggca aaatcctcca gctattcctg     1680

tctgggccag ttttgtaggt ccatctgtgc atgggcagca gtagtcaaaa agccaaggaa     1740

aaaacagagc agacctgaag gctaatctta tttttgccac taacttagtg aatgacccta     1800

agcaagttcc ttctcctctt agggccttgt gccaagccta tgaaattgga ggtggctttc     1860

ctgctctaaa gcattttgat gtctcattct gtgtttggta acccctataa actggggcag     1920

aggaaaagaa tgatggttca aggccatact tcccttgaac cttgtgtggt tcttgcctaa     1980

ctctgtggtt tttggacccc atggggccca gacagagcac aggagcatgg gctgcctctg     2040

agtgtggtgt tgaacttcgg gaggagcagg gagccctgca ccttgtgtcc tggcccacct     2100

gacctttggt gttctccgga tccttttcag cccgaggcct gacagacgcg ggcagtgatg     2160

agccctgttc tggagtggaa agagcacgat agagcaccag gctaagaggc acgagatcaa     2220

ggcggtagtc acttccgctc tgcagctagc atttcaacca tatgtggatc ctttcatttc     2280

tcagctccct ggattccttc ccctaaatta ggacctatta tttacctgta ggtaagcaag     2340

ctactgtagc tcttctgagg tatctgccag gctgttttct gtagcctcag attgcctatc     2400

tgcttagcct gagaacaggt agatgaaaac taaactgatg cctaggccca gggtcagtct     2460

cagatggaag ctgggcctgg gtggggaggc tagcatgcgt ggctccctgg gtatttctgt     2520

cagtccccat ggcaagcagt gatttagtaa aacaccccag agtcagggaa gccaaccacc     2580

ttgaaacctt tagaacatct ctgctttgga gaaagaccca gagatcaggc agaggtgcag     2640

attcaatcat tactcataac ctttgagaga tggcaaatgg gaggagtgtt agtctttgtt     2700

ttggaattgg accattcttg caaccaaaag gacttagagc agtttgctca taaagacatc     2760

ctttattata aaaggaagta tttaaaggat gatagagacc atcagataga agcagggaag     2820

gtagataact tttaggacct tgatgtgagg aaaagataaa atttaaacaa taaatttgcc     2880

acttagattt tctagcagca aagtccgaaa agatagttat atacaaaatt ctgttttctg     2940

aaaacaaaat tgtgattcac cttcagaatt ggccattttt tttgtgagtt tccttgcatc     3000

aaggacactg agaaacacag tcattgtctt aggtgttcta tgggaggaag tgaatagagc     3060

ctttaggaac ttcctggtca agcttatggt gcttattttg atctgggcca cttccctcct     3120

tccagtcatg agtaatcatc aaggagcaag ttggagtgtt tcaggtgtat attttgtaga     3180

acccaaaaga ttggagcctt aacaataaac atcagcacta agtgacctgt tcctcctttt     3240

ttaaatagca gctttattga gatataattt acatacccat aatttacata cctgtttaaa     3300

gtatacaatt cagtggattt agtatgttca cagtgttgca catccaccac catttctaat     3360

tcctgaacat tttcaccacc tcaaaaagaa accacacacc cattggcatg actccccatt     3420

cccttgctcc cagccccagg caaccactaa catctgtctc taaagatttt tttttttttt     3480

ctggacagtt ctcataagtg gaatcactca gtattatggc cttttgtgtc tggcttcttt     3540

catttcatgt gatgttttca agattcattc atgctgtagc atgtatccat ggtatggata     3600

tatcacattt tgcttatcct tttatcagtt gatggacagt tgggttgttt ctacaaaaag     3660

gctattatga gtaatgcagc caagaa                                          3686


<210> 1054
<211> 574
<212> DNA
<213> Homo sapiens

<400> 1054
cggaagccgc ggttcctacc aaccgttctt attgctggcg gcctgaggag cccatcatgg       60

cgacgccccc taagcggcgg gcggtggagg ccacggggga gaaagtgctg cgctacgaga      120

ccttcatcag tgacgtgctg cagcgggact tgcgaaaggt gctggaccat cgagacaagg      180

tatatgagca gctggccaaa taccttcaac tgagaaatgt cattgagcga ctccaggaag      240

ctaagcactc ggagttatat atgcaggtgg atttgggctg taacttcttc gttgacacag      300

tggtcccaga tacttcacgc atctatgtgg ccctgggata tggttttttc ctggagttga      360

cactggcaga agctctcaag ttcattgatc gtaagagctc tctcctcaca gagctcagca      420

acagcctcac caaggactcc atgaatatca aagcccatat ccacatgttg ctagaggggc      480

ttagagaact acaaggcctg cagaatttcc cagagaagcc tcaccattga cttcttcccc      540

ccatcctcag acattaaaga gcctgaatgc cttt                                  574


<210> 1055
<211> 747
<212> DNA
<213> Homo sapiens

<400> 1055
atcctcgtgg gccctgacct tctctctgag agccgggcag aggctccgga gccatgcagg       60

ccgaaggccg gggcacaggg ggttcgacgg gcgatgctga tggcccagga ggccctggca      120

ttcctgatgg cccagggggc aatgctggcg gcccaggaga ggcgggtgcc acgggcggca      180

gaggtccccg gggcgcaggg gcagcaaggg cctcggggcc gggaggaggc gccccgcggg      240

gtccgcatgg cggcgcggct tcagggctga atggatgctg cagatgcggg gccagggggc      300

cggagagccg cctgcttgag ttctacctcg ccatgccttt cgcgacaccc atggaagcag      360

agctggcccg caggagcctg gcccaggatg ccccaccgct tcccgtgcca ggggtgcttc      420

tgaaggagtt cactgtgtcc ggcaacatac tgactatccg actgactgct gcagaccacc      480

gccaactgca gctctccatc agctcctgtc tccagcagct ttccctgttg atgtggatca      540

cgcagtgctt tctgcccgtg tttttggctc agcctccctc agggcagagg cgctaagccc      600

agcctggcgc cccttcctag gtcatgcctc ctcccctagg gaatggtccc agcacgagtg      660

gccagttcat tgtgggggcc tgattgtttg tcgctggagg aggacggctt acatgtttgt      720

ttctgtagaa aataaaactg agctacg                                          747


<210> 1056
<211> 1387
<212> DNA
<213> Homo sapiens

<400> 1056
agttgcaacc cgggccgccc gcagaggcag gcggggccca ggtggcgtgg accgcccgtc       60

accagctctg cctcgccagt ctgagtccga cttattaact agcttccgtc attcatcaac      120

acgcgctatt gggcatcttg cgagcgccgg gctccgcgcc ggcgccggaa tgcgatccgg      180

gcttcggact cgaacgaatg cgggggacga gccaaccctg gtgggggagg ctggggcgga      240

cgcgtttatt agaagatcgg ggccgtttgc ctagacatga acatttggac tcggaggagc      300

agagggacgc cccctcggcc gctccggctg cactgcggag ccgaggcccg cgcgagggcg      360

cagaccgacc aaccggctag ggcctgactg gctagactgt gcccgctgca gaggcgcgct      420

cccagcacag ggcggggacg gaagggagga ccccgagccg cgtgaaacgc aaggccctcg      480

tgtgtgcgca gctgacaccc taggcggggc tgcgtcgggg gcggggacag gcgcgtccca      540

gcccacgcag ccggaacgcc tgagcgctgg gcgcctggtc tgccggacct cagcaggggg      600

caccgcgggc cggactgtgg aggggcgcac gcccggaagc ggcgagggta gccatgacgg      660

cctccgtgct gcgaagtatc tcgctagccc tgcgcccgac tagcgggctt ctgggaactt      720

ggcagacgca gcttagagag actcaccagc gagcgtcatt gttgtctttc tgggaactca      780

ttcccatgag atcagaacct cttcgaaaaa agaagaaggt agatcctaaa aaagaccaag      840

aagcaaagga gcgcttgaaa aggaagatcc gaaaactgga aaaggctact caagagctaa      900

ttcctattga agattttatt acccctctaa agttcttgga taaagcaaga gagcggcctc      960

aggtggagct cacctttgag gagactgaga ggagagctct gcttctgaag aagtggtcct     1020

tgtacaagca gcaagagcgt aagatggaga gggacaccat cagggctatg ctagaagccc     1080

agcaggaagc tctggaggaa ctgcaactgg aatccccgaa gctccatgct gaggccatca     1140

agcgggatcc taacctgttc ccctttgaga aggaagggcc acattacaca ccaccgatcc     1200

ctaactacca accccctgaa ggcaggtaca atgacatcac caaggtgtac acacaagtgg     1260

agtttaagag atagacttgc aggctgctat ccttaacatg ctgcccctga gagtaggaat     1320

gaccagggtt caagtctgct ttccacagaa tcaggcatgc tgttaataaa tactggttta     1380

atcaaaa                                                               1387


<210> 1057
<211> 10141
<212> DNA
<213> Homo sapiens

<400> 1057
aggtctttgc ctccgcgtca ctttctcctc atcgagtccc cggaggcaga gagctgagcg       60

aggttcgcct ccccgggcgg gacacgagct ccggtcctct cttggcgcaa acccccgccc      120

cccgcggagg gactactttt cgtctcccgc ggaggaacta cttcctcccc cgcggaggcg      180

tcggtccagg cggcgcgcac ggtatggcgg cggcggcggc ggcggcggcg cgcgcctgag      240

aagaggggac gccagcccgg tcaggcctcg gcgcggccta cacgctccgc tcgctcgctc      300

gctcccgcct cccgccccgc gcccggccat ggcggagccg tcgtccgccc gacgcccggt      360

gcctctcatc gagtcggagc tgtacttcct tatcgcccgg tacctatcgg cgggcccgtg      420

tcggagagcg gcccaggtgc tggtgcagga gctggagcag taccagttgt tgccgaagag      480

attggactgg gagggcaacg agcacaacag gagctacgag gagttggtct tgtccaataa      540

gcatgtggct cctgatcatc ttttgcaaat ctgccagcgc atcggtccta tgttggataa      600

agaaattcca cccagtattt caagagtcac ttctttactt ggtgcaggaa ggcagtcttt      660

gctacgtaca gcaaaagact gcaggcacac agtttggaag ggctctgcct ttgctgctct      720

tcatagagga agacctcctg aaatgccagt gaattatggt tccccaccaa atcttgtgga      780

gatacatcga ggaaaacaac tcacagggtg ttccactttt agtacagcat ttccaggaac      840

tatgtatcag catataaaaa tgcacagaag gattctcgga catctatctg ctgtttactg      900

tgtagcattt gataggacag gacatagaat ctttacaggt tcagatgact gtttggtaaa      960

gatttggtca acacataatg gccgcttgtt atctacatta agaggtcatt ctgcagaaat     1020

ttcagatatg gcagtaaact atgagaatac aatgattgct gcggggagct gtgataaaat     1080

tattagagtg tggtgcttga gaacttgtgc cccagttgct gtgctccaag gacacacagg     1140

atcaattaca tctttacagt ttagcccgat ggccaaaggc tctcaaagat acatggtttc     1200

cactggtgct gatgggacag tttgcttttg gcaatgggat ttagaatcct taaaatttag     1260

cccacgtccc ctgaagttca ctgaaaagcc taggccaggc gttcaaatgc tttgttcttc     1320

ttttagtgtt ggtggtatgt ttttagccac aggtagtact gatcatgtaa tcagaatgta     1380

ttttttgggt tttgaagcac ccgaaaaaat cgcagaactt gaaagccaca ctgataaagt     1440

agatagtatc caattttgta acaatggtga tcggttccta agtggtagca gagatggaac     1500

agcacggatt tggagatttg agcagttaga atggaggagc attttattgg atatggctac     1560

cagaatctca ggggacttat cttccgaaga ggaaaggttt atgaaaccta aagtaacaat     1620

gatagcttgg aatcaaaatg atagcattgt tgtcacagct gtgaatgatc atgtcctcaa     1680

agtgtggaat tcttacactg gacaactgct tcataactta atgggacatg ctgatgaagt     1740

atttgttctg gagacacatc cctttgattc cagaattatg ttatctgcag gacatgatgg     1800

cagcatattt atatgggata ttacaaaagg taccaagatg aaacattatt ttaatatgat     1860

tgaaggacaa ggacatggag ctgtgtttga ctgtaagttt tcacaggatg gacagcattt     1920

tgcctgtaca gattctcatg ggcaccttct gatatttggt tttggatgca gcaaaccata     1980

tgaaaagatt cctgatcaga tgttcttcca tactgactat cgaccactta ttagagattc     2040

taataattat gtcttagatg agcaaactca gcaggctcct catcttatgc ctccaccatt     2100

cttggtagat gtagatggaa atcctcatcc aaccaagtat cagagattag taccaggccg     2160

agaaaattct gcagatgaac atttgattcc acagctgggc tatgtggcaa caagtgatgg     2220

agaggtgatt gaacaaatta taagcctgca aaccaatgat aatgatgaac gcagcccaga     2280

atcgagtatt cttgatggaa tgataagaca gttgcagcag cagcaagatc agagaatggg     2340

agcagatcag gatactattc caagaggact ttcaaatggt gaagaaacac cccggagagg     2400

ttttagaagg ctgagcttag acattcagtc ccctccaaat attggtctgc gtcgtagtgg     2460

acaagttgaa ggtgttcgtc agatgcatca aaacgctcca cgcagtcaga ttgctacaga     2520

acgtgacctg caggcttgga aacgaagagt ggttgtacca gaggtaccac taggcatatt     2580

taggaagctg gaagacttcc gattagagaa aggtgaagag gaaagaaatc tttatataat     2640

aggaagaaaa agaaagactc ttcagctctc acataagtcg gattcagtgg ttttggtatc     2700

acagtctaga caaaggacat gtaggcgtaa atatccaaat tatggtagaa gaaatcgtag     2760

ctggcgtgag ttatcttctg gaaatgagtc ttcaagctct gtaagacatg agacttcctg     2820

tgatcagagt gaaggttctg gttcttcaga agaggatgaa tggagaagtg acagaaaaag     2880

tgagagttac agcgaaagtt caagtgactc ttcatctaga tattccgatt ggacagctga     2940

tgcgggcatc aatttgcagc ctcctttaag aacatcatgt cgtcgacgaa ttactcgatt     3000

ttgtagtagt tcagaagatg aaatatctac tgagaattta tctcctccaa aaagaagacg     3060

aaagagaaag aaagaaaata agcctaagaa ggagaatttg cggaggatga ctccagcaga     3120

gcttgcaaat atggagcatt tatatgaatt tcaccctcca gtttggatta ctgacaccac     3180

acttagaaaa tctccttttg ttcctcaaat gggtgatgag gtaatatatt ttcgacaggg     3240

tcatgaagct tatattgagg ctgtaagaag aaataatatt tatgaactga accctaataa     3300

ggagccatgg agaaaaatgg atcttaggga tcaagaattg gttaaaatag ttggaatacg     3360

atatgaagtt gggcccccta cactctgttg cctaaaacta gcatttatag atccagcaac     3420

tggaaaactt atggacaaat ctttctctat tagatatcat gatatgccag atgttattga     3480

ctttcttgta ttgcgtcaat tttatgatga agcaagacag aggaattggc agtcttgtga     3540

cagattccgc tctattattg atgatgcttg gtggtttgga acagtgttaa gtcaagagcc     3600

atatcaacca cagtatcctg atagtcattt ccagtgttat attgttaggt gggataatac     3660

tgaaattgaa aaacttagcc catgggacat ggaaccaatt cctgataatg ttgatccacc     3720

tgaagaatta ggagctagta tttctgtcac aacagatgag ctagagaaat tgctctataa     3780

accacaagct ggtgaatggg gtcagaaatc aagagatgaa gaatgtgata gaattatcag     3840

tggtatagat caacttttga atcttgatat agcagcagct tttgcaggcc ctgttgattt     3900

gtgtacatac ccgaagtact gtactgtagt agcttatcca accgatcttt acacaattcg     3960

aatgagactt gttaatcgat tttacaggag gctgtctgcg ttagtttggg aagtcagata     4020

tatagaacat aatgccagaa catttaacga acctgagagt gtaattgcaa gatcagctaa     4080

aaagataact gaccaacttt taaaatttat caagaatcaa cactgtacaa atatctcaga     4140

actttctaac acatctgaaa atgatgagca aaatgctgag gatttggatg atagtgatct     4200

tcctaaaaca tcttctggaa ggaggagagt ccatgatggg aaaaaaagca tcagagctac     4260

gaactatgtt gaaagcaact ggaagaaaca gtgtaaggaa ctagtgaact taatttttca     4320

gtgtgaagat tctgaaccat ttagacaacc tgttgatttg gttgaatatc cagactacag     4380

agatattata gataccccaa tggattttgg aacagtaagg gaaactctag atgcgggaaa     4440

ttatgacagc cctttggagt tttgcaaaga catccggctg atatttagca atgcaaaagc     4500

gtatacacca aacaaaagat caaagattta tagtatgacc ttgagattat ctgccttatt     4560

tgaagaaaaa atgaagaaaa tctcttctga ttttaaaatt ggtcaaaaat tcaatgaaaa     4620

acttcgaaga agccagaggt tcaagcaacg gcaaaattgt aaaggtgaca gtcagcctaa     4680

caaaagtatc agaaacctca agccgaagag gttaaaatct cagacaaaaa taattcctga     4740

gttggtaggt tctcctaccc agtctacctc aagtaggaca gcttatcttg gaacccacaa     4800

gacaagtgct ggtatctctt caggtgttac ttctggtgac tcttcagatt cagcagaatc     4860

atcagaaagg aggaaaagaa atagacctat aacaaatggt tctacattat ctgaaagtga     4920

agtggaagat tctttagcta cctctttgtc atcgtcagct tccagtagtt ctgaggaaag     4980

caaagagagt tccagagctc gtgaatcctc ctcacgcagt gggctatcca gaagcagcaa     5040

tctcagggta accagaacta gagctgctca aagaaaaact ggtcccgttt cattagcaaa     5100

tggatgtggc agaaaagcca ctcgaaagag agtctattta agtgattctg ataacaattc     5160

attggagact ggtgaaattc taaaagccag agctggaaat aaccgaaaag tcttaaggaa     5220

gtgtgctgct gtggctgcca ataaaataaa gctaatgagt gatgtagaag agaattctag     5280

ctctgaaagt gtctgttctg gtcggaagct gcctcaccgc aatgcttctg ctgtagctag     5340

aaaaaagtta ttacataatt ctgaagatga acagagctta aagtcagaaa ttgaagaaga     5400

ggagctaaaa gatgaaaatc aactattacc agtgtccagt tctcacactg cccagagcaa     5460

tgttgatgaa tctgaaaaca gagactcaga gtcagaaagt gatttgcggg tagcccggaa     5520

aaattggcat gctaatggtt acaagtccca tactccagca ccttcaaaga caaaatttct     5580

taaaatagag tcttctgagg aagactctaa aagtcatgat tcagatcatg catgtaacag     5640

aactgctggc ccatcaacgt ctgtgcagaa acttaaggca gagagcatct cagaggaagc     5700

agattctgaa ccaggaagat ctggtggtag gaaatacaat acatttcaca agaatgcgag     5760

tttctttaaa aaaaccaaga ttctgagtga ctcagaagac tctgaatctg aagagcaaga     5820

tagagaagat gggaaatgtc ataaaatgga aatgaaccca atttcaggaa atctgaactg     5880

tgaccctatt gctatgtccc agtgttcctc agatcatgga tgtgaaactg atttagattc     5940

agatgatgac aaaatagaaa aaccaaacaa ttttatgaaa gattctgcat cacaagacaa     6000

tggactaagc agaaaaattt ccaggaaaag ggtctgttcc agtgactcag acagtagttt     6060

acaggtggtt aagaaatcat caaaagccag aacaggtctc ctgaggatta ctcgaagatg     6120

tgcagctacg gctgccaata agatcaagct catgagtgat gtagaagatg tcagtttaga     6180

aaatgtgcac actagaagca aaaatggaag gaaaaaacct ctccatcttg cttgtactac     6240

agctaagaag aaattgagtg attgtgaagg aagtgtacat tgtgaagtac caagtgaaca     6300

gtatgcctgt gaaggcaagc cacctgatcc tgactccgaa ggtagtacaa aagtgcttag     6360

tcaggctcta aatggagact cagactctga agatatgttg aattcagaac acaagcacag     6420

gcataccaat attcacaaaa tagatgcacc ttctaaaaga aaaagttcct ctgttacatc     6480

ttcaggagaa gattcaaaaa gtcatattcc agggagtgag actgatagga cattttcttc     6540

agagtcaacc ttggcacaaa aagctactgc agagaataat tttgaagtgg aactgaatta     6600

tgggctgcgc aggtggaatg gcagaagact caggacctat ggaaaggctc cttttagtaa     6660

gacaaaagtg attcatgatt cacaggaaac agcagagaag gaagtaaaaa ggaagagatc     6720

gcatcctgaa ttggaaaatg tgaaaatctc tgaaacaact gggaattcaa agtttagacc     6780

tgatactagt tccaaatcat cagatttggg atctgtaact gaatcagata ttgactgtac     6840

tgataataca aaaaccaaaa ggaggaaaac gaaaggaaaa gcaaaagtag ttagaaaaga     6900

atttgttcct agagacagag aacccaatac aaaagtgaga acatgtatgc ataatcagaa     6960

ggatgcagtg cagatgccta gtgaaactct gaaagcaaaa atggtacctg agaaagttcc     7020

ccgcagatgt gctactgttg ctgcaaataa aataaagata atgagtaatc taaaagaaac     7080

gatctcagga ccagaaaatg tctggattag gaagagtagc agaaaactgc cccatcgaaa     7140

tgcttctgct gcggctaaga aaaaattact gaatgtttat aaagaggatg atacaaccat     7200

aaattctgaa agtgaaaaag agctagaaga tattaataga aaaatgcttt ttttaagggg     7260

gttcagatcc tggaaagaaa atgcacaata gtgactatga gaatgtagaa gtggcatctg     7320

aaaacaattg gtacacaagt aaactggcag ttacattctg ctcccagctc taaaattact     7380

cccttattgg catctttgga ggaattttct aaaagccata atccagtggg ttcctcccag     7440

tcagctcttg tacagacatg tgctctgggg aattctgagg aggaaataaa ttgcagagtc     7500

tgtaggtgga gaggtggaaa gaaaagacaa atggcctgct ataagactac tattcctttc     7560

cagaatgcaa ggccttgaag acatgattcc ttagaggaag aatataatgg gaagtgtaca     7620

ggctaggaag aacttgaagt gaacaaattt caaaatctta acctgatgct aattttcagg     7680

gttctccatt acagtgtaaa aattcagacc acgacaacta tggtgtcatg aggaaaaaaa     7740

atcaggcatt tttccaaagg aagtgctaat gggcctattt gacttctgag tgaagcaaaa     7800

actacccaga tccattccct acaattcaca tccccaaagg tcaaaaacaa actaggagga     7860

cctgggaatt tcagctggag atactgatta ttgagttctg aagtagagtg ttggaaatag     7920

gcaattagag aaagtccatt gatgtcattt tgtttataat attgcagttc atactgaatg     7980

accacttgat atgactaatt cagggaatat atatttttct atgaaagcta tgaatgttac     8040

tatcacggct tttccttatt tttacttgta tgtagcagca tttacagaaa tgccaaaaat     8100

gtgcctcatt aagaggcagg tcttaatcag ttagataaaa ataaaatgta tagcttaaga     8160

tcaaaacagt catattttta gatacagtga aatcttttat gtttctctac agcaccttaa     8220

aaattagaac ttgaatactt tgagtaaact tactacaatc tcatcccaac aaactttaat     8280

ggtagcatgt ttggcctatt tcattgtggc ctgtactagg attagaaaat ttggtcgtgg     8340

tataacaaag aagtgtattt acaataggat ttaatttgtt gttaatatgt atttgttgaa     8400

attaaaattg ccagattaaa tgaatatact gtcgcatctt tttaacatag taacgtgtta     8460

ctggaaaaat taagttgttg aaagtaagtt gttttcccat ttaaaaatat ctgaatatat     8520

gatttgcatg tgtaaatctg aaaaactaaa ctacagaaac ctagggtttt ctatttcttt     8580

tttaagtcaa atgcattttt ttttttttgt tatacagatg aaccaagtgt ctaaaatact     8640

tgagaaattt gtggttgcat gtctgtttta aaaaaaaggc tttttgtttt ttagcataag     8700

ccagaatatt ctaacctact aagtctgtgt cctttgctcc ttttgtagta tactttcatc     8760

taaattactg atccccaata tgttgataca caggtgagaa agggaagaat tcctaataaa     8820

ctgctattac ttttaggtgc atggggtttg atttttgagc tctaatgaaa tgcttaaact     8880

tctttccagt tcaaatttta cacttaattt ataatattta ttgagtatat tatgtcctca     8940

acaagtaact ataaaatgaa atacttaact cggtgaagac tattttatgc aaagtttttt     9000

tttttttttt tttttttttt tagcaatttc agtgtaatga aagaatttaa gctttgaatt     9060

tataatttgc tgtggtgggg ttaatttctg tcagtatttg agattgtatt atcagtcttg     9120

cataatgaaa tccttttttg gctaagtatt taattcgaac atatttgcct ttttaaaaag     9180

tgcttggcct aaacttattg taactgcatg aaataagcat ttgcttaaaa cttaacattg     9240

taaaattgtt ctctctgaaa tgtgtgcaga atttaaatca tggccaaatg tattactatt     9300

accctattta cagtaatttg ctttgcagaa aatatttctt catcatggaa ctgtgaaatc     9360

aaattgaaga tcttactggt aaaaatgaca aattaacaaa aggactaaga caagtggtgc     9420

ccaaacaacc tttttattct gcagttccat catcataata gaccagttaa cccaggagtc     9480

ctaatgtttt aaaacatcat tgtggtgatc ttgtttattc tatctcacta aggatatcca     9540

gtttcctaag ctcttactgg ctagcaattt cgtcttaatt ttattgctaa atgttcaaat     9600

tttgcttcca aactcacttt atttttgcag atgtgtacat ctgctaagta ctaattttat     9660

gtaaatgatt ttgttgatta tctttccaca tcttaaaatg tttctaacag ctttgagatt     9720

ttatctcaac aggctctctc tgaccccaaa gtagtactta ccttcgtgac tactgacaaa     9780

gtcacaaaat gcaggcgatg tcatgtattt cggtacaact aaatctagga aacggttttt     9840

tcattgcatt actgcatatt ttcattttca tttaaattat gtcccctttt tctcttgctt     9900

gaaacagtgc tcctcgaact ttgtcttcca gcacatttta aagagaacca attaaagaac     9960

aatcacacat tctgcttatt aaaggctatt taaaaagaaa cattttgtat tagaaaatgg    10020

ccaactttaa aacactattt tttacactca taaaaatgtt ttttaaatcg ccttgacaat    10080

catcagcttt tgaaatgtga attcctattg ccagagtaaa ggtctcgttt ttataccacc    10140

a                                                                    10141


<210> 1058
<211> 2986
<212> DNA
<213> Homo sapiens

<400> 1058
acacctcagt tcacaatcct ggggcgatat ggcagaatct tttttttcgg attttggctt       60

gttgtggtat ctgaaggagc tcagaaagga agagttttgg aaatttaagg agctcctcaa      120

acaacctttg gagaaatttg aactcaagcc aatcccctgg gctgagctga agaaggcctc      180

caaagaagat gtagcaaagc tgctggacaa acattaccca ggaaagcagg catgggaggt      240

aacactgaac ctgtttctac agatcaatag gaaagatctc tggacaaagg ctcaggaaga      300

gatgagaaat aagctaaacc catacagaaa gcatatgaag gaaacatttc aactcatatg      360

ggagaaggaa acctgtcttc acgtccctga gcatttctac aaagaaacca tgaaaaatga      420

gtataaagaa ttgaatgacg catatactgc tgcggctaga cgacacactg tggtcctgga      480

aggtcctgat ggaattggaa aaacaaccct tttaagaaaa gtgatgttgg actgggcaga      540

gggaaactta tggaaggaca ggttcacatt tgtgtttttc ctcaatgtct gtgaaatgaa      600

cggtatcgca gagaccagct tactggagct cctctctagg gactggccgg agtcttcaga      660

gaagatcgaa gacatttttt cccagccaga gagaattctg ttcatcatgg atggctttga      720

gcaactgaag tttaacttac aacttaaggc tgacttgagc gatgattgga ggcagcggca      780

gccaatgcca attatcctga gcagtttgtt gcaaaaaaag atgcttccag aatcctctct      840

ccttattgca ttaggaaaac tggctatgca aaaacactat tttatgttgc ggcatccaaa      900

actcataaag ctcttaggat tcagtgaatc tgaaaagaag tcgtatttct cctacttctt      960

tggtgagaag agcaaagccc tgaaagtctt caattttgtg agagataatg ggccgctgtt     1020

tatcttgtgc cataatccct ttacgtgctg gttggtctgt acttgtgtga aacagaggct     1080

agagagggga gaagaccttg aaataaactc ccaaaacacc acctatttat atgcatcctt     1140

tttaacaact gtattcaaag caggaagtca gagttttcca cctaaggtga acagagcccg     1200

actaaaaagc ctgtgtgctt tggctgcaga gggaatttgg acatatacat ttgtattttc     1260

ccatggggat ctccggagga atgggttatc tgagtctgag ggcgtgatgt gggtgggtat     1320

gagactcctc caaaggagag gggactgttt tgccttcatg catctgtgta tccaagagtt     1380

ttgtgccgcc atgttttatt tgctcaaacg acccaaagac gatcctaacc cggccattgg     1440

aagcataacc cagcttgtaa gagcaagtgt ggttcagcct caaaccctct tgacccaggt     1500

ggggatattc atgtttggaa tttcaacaga agaaatcgtc agcatgctgg agacctcctt     1560

tggttttcca ctgtcaaaag acctaaagca ggaaataacc caatgccttg aaagtttaag     1620

tcaatgtgaa gctgataggg aagccatagc tttccaggaa ctattcattg gtttgtttga     1680

aactcaggaa aaagaatttg taaccaaagt gatgaatttc tttgaagaag ttttcattta     1740

tattggtaac atagaacatt tggtaatagc ttcattctgc ctgaagcatt gtcaacattt     1800

aacgacactt cgcatgtgtg tggagaatat ctttccagat gactcaggat gcatctcaga     1860

ttacaatgag aagctcgtct actggcggga gctttgctca atgttcatta ccaacaagaa     1920

cttccagatt ttagacatgg aaaataccag ccttgatgat ccctccctgg cgattctttg     1980

caaagcgctg gctcagcctg tttgtaaact ccgaaaactc atatttactt ctgtgtactt     2040

tggacatgat tcagaattat ttaaggcagt tcttcacaac cctcatctga aacttctgag     2100

cctgtacggc actagcctct cccagtctga catcagacac ctgtgtgaga cgctgaaaca     2160

tccaatgtgc aagatagaag agctgatact gggaaagtgt gacatctcca gtgaagtttg     2220

tgaagacatc gcctccgtcc tggcctgcaa cagcaagctg aaacacctct ccttggtaga     2280

aaatcccttg agggacgaag gaatgacgtt gctgtgtgaa gccctgaagc actcacactg     2340

tgccctggag aggctgatgt tgatgtactg ctgtctcacc tctgtctcct gtgactccat     2400

ttccgaagtc ctcttgtgca gtaagtccct gtccctcctc gatctgggct caaatgccct     2460

ggaagataat ggagtggcat ctctgtgtgc agcgctgaag cacccaggct gcagcatacg     2520

ggagctgtgg ttgatgggct gtttccttac ttccgattcc tgtaaggaca ttgctgctgt     2580

tcttatttgc aatgggaaac tgaagaccct gaaacttggg cataatgaaa taggagacac     2640

tggtgtcaga cagttatgtg cagctttgca gcatcctcac tgtaaattag agtgtctcgg     2700

gctgcaaacg tgtccgatca cccgtgcctg ctgcgacgac atcgccgcag cactcatcgc     2760

ctgcaaaaca ctgaggagcc tgaacctcga ctggattgcc ttggatgctg atgcagtggt     2820

ggtgctgtgt gaggcattga gccacccgga ctgtgccctg cagatgctgg gaaattgtca     2880

gaagtccctc ggagacacag ttgcaccagg tgagaaccac tgctctataa aacatcttct     2940

acttacgttg cccataaata tgcaacgcca gctcagactt cagaag                    2986


<210> 1059
<211> 3299
<212> DNA
<213> Homo sapiens

<400> 1059
ccaggaagag agctgtgacc agcagcgtcc cttattcgct tggccttggt tcctgtttgc       60

actggctaca gcagggcact ggcccctact gtcaccgcca cctacacaaa gaccctatct      120

ctgagcgctg cagcctactg ttcagcccca ggtttgagga tggatgccct ggacgcttcg      180

aagctactgg atgaggagct gtattcaaga cagctgtatg tgctgggctc acctgccatg      240

cagaggattc agggagccag ggtcctggtg tcaggcctgc agggcctggg ggccgaggtg      300

gccaagaact tggttctgat gggtgtgggc agcctcactc tgcatgatcc ccaccccacc      360

tgctggtccg acctggctgc ccagtttctc ctctcagagc aggacttgga aaggagcaga      420

gccgaggcct ctcaagagct cttggctcag ctcaacagag ctgtccaggt cgtcgtgcac      480

acgggtgaca tcactgagga cctgctgttg gacttccagg tggtggtgct gactgctgca      540

aagctggagg agcagctgaa ggtgggcacc ttgtgtcata agcatggagt ttgctttctg      600

gcggctgaca cccggggcct cgtggggcag ttgttctgtg actttggtga ggacttcact      660

gtgcaggacc ccacagaggc agaacccctg acagctgcca tccagcacat ctcccagggc      720

tcccctggca ttctcactct gaggaaaggg gccaataccc actacttccg tgatggagac      780

ttggtgactt tctcgggaat tgagggaatg gttgagctca acgactgtga tccccggtct      840

atccacgtgc gggaggatgg gtccctggag attggagaca caacaacttt ctctcggtac      900

ttgcgtggtg gggctatcac tgaagtcaag agacccaaga ctgtgagaca taagtccctg      960

gacacagccc tgctccagcc ccatgtggtg gcccagagct cccaggaagt tcaccatgcc     1020

cactgcctgc atcaggcctt ctgtgcactg cacaagttcc agcacctcca tggccggcca     1080

ccccagccct gggatcctgt tgatgcagag actgtggtgg gcctggcccg ggacctggaa     1140

ccactgaagc ggacagagga agagccactg gaagagccac tggatgaggc cctagtgcgg     1200

acagtcgccc taagcagtgc aggtgtcttg agccctatgg tggccatgct gggtgcagta     1260

gctgcccagg aagtgctgaa ggcaatctcc aggaagttca tgcctctgga ccagtggctt     1320

tactttgatg ccctcgattg tcttccggaa gatggggagc tccttcccag tcctgaggac     1380

tgtgccctga gaggcagccg ctatgatggg caaattgcag tgtttggggc tggttttcag     1440

gagaaactga gacgccagca ctacctcctg gtgggcgctg gtgccattgg ttgtgagctg     1500

ctcaaagtct ttgccctagt gggactgggg gccgggaaca gcgggggctt gactgttgtt     1560

gacatggacc acatagagcg ctccaatctc agccgtcagt tcctcttcag gtcccaggac     1620

gttggtagac ccaaggcaga ggtggctgca gcagctgccc ggggcctgaa cccagactta     1680

caggtgatcc cgctcaccta cccactggat cccaccacag agcacatcta tggggataac     1740

tttttctccc gtgtggatgg tgtggctgct gccctggaca gtttccaggc ccggcgctat     1800

gtggctgctc gttgcaccca ctatctgaag ccactgctgg aggcaggcac atcgggcacc     1860

tggggcagtg ctacagtatt catgccacat gtgactgagg cctacagagc ccctgcctca     1920

gctgcagctt ctgaggatgc cccctaccct gtctgtaccg tgcggtactt ccctagcaca     1980

gccgagcaca ccctgcagtg ggcccggcat gagtttgaag aactcttccg actgtctgca     2040

gagaccatca accaccacca acaggcacac acttccctgg cagacatgga tgagccacag     2100

acactcacct tactgaagcc agtgcttggg gtcctgagag tgcgtccaca gaactggcaa     2160

gactgtgtgg cgtgggctct tggccactgg aaactctgct ttcattatgg catcaaacag     2220

ctgctgaggc acttcccacc taataaagtg cttgaggatg gaactccctt ctggtcaggt     2280

cccaaacagt gtccccagcc cttggagttt gacaccaacc aagacacaca cctcctctac     2340

gtactggcag ctgccaacct gtatgcccag atgcatgggc tgcctggctc acaggactgg     2400

actgcactca gggagctgct gaagctgctg ccacagcctg acccccaaca gatggccccc     2460

atctttgcta gtaatctaga gctggcttcg gcttctgctg agtttggccc tgagcagcag     2520

aaggaactga acaaagccct ggaagtctgg agtgtgggcc ctcccctgaa gcctctgatg     2580

tttgagaagg atgatgacag caacttccat gtggactttg tggtagcggc agctagcctg     2640

agatgtcaga actacgggat tccaccggtc aaccgtgccc agagcaagcg aattgtgggc     2700

cagattatcc cagccattgc caccactaca gcagctgtgg caggcctgtt gggcctggag     2760

ctgtataagg tggtgagtgg gccacggcct cgtagtgcct ttcgccacag ctacctacat     2820

ctggctgaaa actacctcat ccgctatatg ccttttgccc cagccatcca gacgttccat     2880

cacctgaagt ggacctcttg ggaccgtctg aaggtaccag ctgggcagcc tgagaggacc     2940

ctggagtcgc tgctggctca tcttcaggag cagcacgggt tgagggtgag gatcctgctg     3000

cacggctcag ccctgctcta tgcggccgga tggtcacctg aaaagcaggc ccagcacctg     3060

cccctcaggg tgacagaact ggttcagcag ctgacaggcc aggcacctgc tcctgggcag     3120

cgggtgttgg tgctagagct gagctgtgag ggtgacgacg aggacactgc cttcccacct     3180

ctgcactatg agctgtgaca aggcagccac cctgtcacct agctcaatgg agccccggat     3240

cccaagccct gcattgtaag cccacagtag gcactcaata aatgcttgtt aaaggaagg      3299


<210> 1060
<211> 1350
<212> DNA
<213> Homo sapiens

<400> 1060
atgcacacat acgcgcgcgc acatgcacat aggcacacag agatacgcgc acacacacac       60

acaaacgcac tcagatttcc cggaccctgg ttttcctcct gtgacccttt cggggccggg      120

ctctcaccct aaagaagcag ccccgccctg gggtggcccc accctctctt gggacctgtc      180

ataagtcgga ccccgggcgc ccggctgcgc agtcccagcc gccttcccca ggcagtggaa      240

ccttcgggct cctgagcttc aggatggttc gtactaagac atggaccctg aagaagcact      300

ttgttggcta tcctactaat agtgactttg agttgaagac agctgagctc ccacccttaa      360

aaaatggaga ggtcctgctt gaagctttgt tcctcaccgt ggatccctac atgagagttg      420

tggaaagtaa aaatgtagcc ctaccaaaag gaactattgt actggcttct ccaggctgga      480

caacgcactc catttctgat gggaaagatc tggaaaagct gctgacagag tggccagaca      540

caataccact gtctttggct ctggggacag ttggcatgcc aggcctgact gcctactttg      600

gcctacttga aatctgtggt gtgaagggtg gagaaacagt gatggttaat gcagcagctg      660

gagctgtggg ctcagtcgtg gggcagattg caaagctcaa gggctgcaaa gttgttggag      720

cagtagggtc tgatgaaaag gttgcctacc ttcaaaagct tggatttgat gtcgtcttta      780

actacaagac ggtagagtct ttggaagaaa ccttgaagaa agcgtctcct gatggttatg      840

attgttattt tgataatgta ggtggagagt tttcaaacac tgttatcggc cagatgaaga      900

aatttggaag gattgccata tgtggagcca tctctacata taacagaacc ggcccacttc      960

ccccaggccc acccccagag attgttatct atcaggagct tcgcatggaa gcttttgtcg     1020

tctaccgctg gcaaggagat gcccgccaaa aagctctgaa ggacttgctg aaatgggtct     1080

tagagggtaa aatccagtac aaggaatata tcattgaagg atttgaaaac atgccagctg     1140

catttatggg aatgctgaaa ggagataatt tggggaagac aatagtgaaa gcatgaaaaa     1200

gaggacacat ggaatctgga ggccatttag atgattagtt aatttgtttt tcaccattta     1260

gcaaaaatgt atactacctt aaatgtctta agaaatagta ctcataatga gtttgagcta     1320

cttaataaaa tacatttaag tggtatgtaa                                      1350


<210> 1061
<211> 2230
<212> DNA
<213> Homo sapiens

<400> 1061
caggtcctag agcagctcca gcaggatggc ggctccagcg tctctaaggc ctgcaggggg       60

tccagcccca tggggggcgc cctaggcctc cgacagctcc ccatctgtgc tcctgcctgc      120

cggccatcct caggccactc gccatgggcg gctgcttctc caaacccaaa ccagtggagc      180

tcaagatcga ggtggtgctg cctgagaagg agcgaggcaa ggaggagctg tcggccagtg      240

ggaagggcag cccccgggcc taccagggca atggcacggc ccgccacttc cacacggagg      300

agcgcctgtc cacccctcac ccctacccca gccctcagga ttgcgtggag gctgctgtct      360

gccacgtcaa ggacctcgag aatggccaga tgcgggaagt ggagctgggc tgggggaagg      420

tgttgctggt gaaggacaat ggggagttcc acgccctggg ccataagtgt ccgcactacg      480

gcgcacccct ggtgaaaggc gttctgtccc gtggtcgggt gcgctgcccc tggcacggcg      540

cctgcttcaa catcagcact ggggacctgg aggacttccc tggcctggac agtctacaca      600

agttccaggt gaagattgag aaggagaagg tgtacgtccg ggccagcaag caggccctac      660

agctgcagcg aaggaccaag gtgatggcca agtgtatctc tccaagtgct gggtacagca      720

gtagcaccaa tgtgctcatt gtgggtgcag gtgcagctgg cctggtgtgt gcagagacac      780

tgcggcagga gggcttctcc gaccggatcg tcctgtgcac gctagaccgg caccttccct      840

acgaccgtcc caagctcagc aagtccctgg acacacagcc tgagcagctg gccctgaggc      900

ccaaggagtt tttccgagcc tatggcatcg aggtgctcac cgaggctcag gtggtcacag      960

tggacgtgag aactaagaag gtcgtgttca aggatggctt caagctggag tacagcaagc     1020

tgctgctggc accagggagc agccccaaga ctctgagctg caaaggcaaa gaagtggaga     1080

acgtgttcac tatccggacg ccagaggatg ccaatcgcgt ggtgaggctg gcccgaggcc     1140

gcaacgtggt cgtcgtggga gccggcttcc tggggatgga ggtggccgct tacctgacgg     1200

agaaggccca ctctgtgtct gtggtggagc tggaggagac gcccttcagg aggttcctgg     1260

gggagcgcgt gggtcgagcc ctcatgaaga tgtttgagaa caaccgggtg aagttctaca     1320

tgcagacgga ggtgtctgag ctgcggggcc aggagggaaa gctgaaggag gttgtgctga     1380

agagcagcaa ggtcgtgcgg gctgacgtct gcgtggtggg cattggtgca gtgcccgcca     1440

caggcttcct gaggcaaagc ggcatcggtt tggattcccg aggcttcatc cctgtcaaca     1500

agatgatgca gaccaatgtc ccaggcgtgt ttgcagctgg cgatgctgtc accttccccc     1560

ttgcctggag gaacaaccgc aaagtgaaca ttccacattg gcagatggct catgctcagg     1620

ggcgcgtggc agcccagaac atgttggcgc aggaggcgga gatgagcact gtgccctacc     1680

tctggaccgc catgtttggc aagagcctgc gctacgcggg ctacggagaa ggcttcgacg     1740

acgtcatcat ccagggggat ctggaggagc tgaagtttgt ggctttttac actaaaggcg     1800

acgaggtgat cgccgtggcc agcatgaact acgatcccat tgtgtccaag gtcgctgagg     1860

tgctggcctc aggccgtgcc atccggaagc gggaggtgga gactggcgac atgtcctggc     1920

ttacggggaa aggatcctga gctcacatgc agtagacttg ggcaggcaaa gggggcacca     1980

agggcacagg ccaagccttg ggggcaggtg ccaatctcca gtcccaggat cccccagggc     2040

agaacctgag ccctcccagt gcttgccttc agccacctgg ctcccctcct gggaggcctc     2100

tgctggatcc agaagatgct caaccctcaa ggcctctgct gccactgaca gctggcactg     2160

gaggcaggac aagccctgcc tcttctccct ctattgggac tggtcccctg aagaaccctg     2220

caacacgtta                                                            2230


<210> 1062
<211> 3462
<212> DNA
<213> Homo sapiens

<400> 1062
ctcaagaatg ccagtgtgtg tgtagcctcc acagagaggt cgttttctcg gagtccagag       60

gggccgcctg agcttctgag aactagggag gagccatccc agccatgagc ccctgtggga      120

atctgctggg ggccaagtgg cctggagtcc tcaggctccc gcagctgctc cggagggaga      180

ggtgagctca gggcagcctg cctgcagcca gaggtgccgg gagccccggg cctgtcatgg      240

tggccatcta cagccggcct gaggcagtca cagacggatt tgcagctgag cctgtctatc      300

tggtgtggga agaagatggg gagttacttg tcagtcccgg cttacttcac ctccagagac      360

ctgtttcggt gttcagaatg ccaggattcc ctcaccaact ggtactatga gaaggatggg      420

aagctctact gccccaagga ctactggggg aagtttgggg agttctgtca tgggtgctcc      480

ctgctgatga cagggccttt tatggtggct ggggagttca agtaccaccc agagtgcttt      540

gcctgtatga gctgcaaggt gatcattgag gatggggatg catatgcact ggtgcagcat      600

gccaccctct actgtgggaa gtgccacaat gaggtggtgc tggcacccat gtttgagaga      660

ctctccacag agtctgttca ggagcagctg ccctactctg tcacgctcat ctccatgccg      720

gccaccactg aaggcaggcg gggcttctcc gtgtccgtgg agagtgcctg ctccaactac      780

gccaccactg tgcaagtgaa agaggtcaac cggatgcaca tcagtcccaa caatcgaaac      840

gccatccacc ctggggaccg catcctggag atcaatggga cccccgtccg cacacttcga      900

gtggaggagg tggaggatgc aattagccag acgagccaga cacttcagct gttgattgaa      960

catgaccccg tctcccaacg cctggaccag ctgcggctgg aggcccggct cgctcctcac     1020

atgcagaatg ccggacaccc ccacgccctc agcaccctgg acaccaagga gaatctggag     1080

gggacactga ggagacgttc cctaaggcgc agtaacagta tctccaagtc ccctggcccc     1140

agctccccaa aggagcccct gctgttcagc cgtgacatca gccgctcaga atcccttcgt     1200

tgttccagca gctattcaca gcagatcttc cggccctgtg acctaatcca tggggaggtc     1260

ctggggaagg gcttctttgg gcaggctatc aaggtgacac acaaagccac gggcaaagtg     1320

atggtcatga aagagttaat tcgatgtgat gaggagaccc agaaaacttt tctgactgag     1380

gtgaaagtga tgcgcagcct ggaccacccc aatgtgctca agttcattgg tgtgctgtac     1440

aaggataaga agctgaacct cctgacagag tacattgagg ggggcacact gaaggacttt     1500

ctgcgcagta tggatccgtt cccctggcag cagaaggtca ggtttgccaa aggaatcgcc     1560

tccggaatgg cctatttgca ctctatgtgc atcatccacc gggatctgaa ctcgcacaac     1620

tgcctcatca agttggacaa gactgtggtg gtggcagact ttgggctgtc acggctcata     1680

gtggaagaga ggaaaagggc ccccatggag aaggccacca ccaagaaacg caccttgcgc     1740

aagaacgacc gcaagaagcg ctacacggtg gtgggaaacc cctactggat ggcccctgag     1800

atgctgaacg gaaagagcta tgatgagacg gtggatatct tctcctttgg gatcgttctc     1860

tgtgagatca ttgggcaggt gtatgcagat cctgactgcc ttccccgaac actggacttt     1920

ggcctcaacg tgaagctttt ctgggagaag tttgttccca cagattgtcc cccggccttc     1980

ttcccgctgg ccgccatctg ctgcagactg gagcctgaga gcagaccagc attctcgaaa     2040

ttggaggact cctttgaggc cctctccctg tacctggggg agctgggcat cccgctgcct     2100

gcagagctgg aggagttgga ccacactgtg agcatgcagt acggcctgac ccgggactca     2160

cctccctagc cctggcccag ccccctgcag gggggtgttc tacagccagc attgcccctc     2220

tgtgccccat tcctgctgtg agcagggccg tccgggcttc ctgtggattg gcggaatgtt     2280

tagaagcaga acaagccatt cctattacct ccccaggagg caagtgggcg cagcaccagg     2340

gaaatgtatc tccacaggtt ctggggccta gttactgtct gtaaatccaa tacttgcctg     2400

aaagctgtga agaagaaaaa aacccctggc ctttgggcca ggaggaatct gttactcgaa     2460

tccacccagg aactccctgg cagtggattg tgggaggctc ttgcttacac taatcagcgt     2520

gacctggacc tgctgggcag gatcccaggg tgaacctgcc tgtgaactct gaagtcacta     2580

gtccagctgg gtgcaggagg acttcaagtg tgtggacgaa agaaagactg atggctcaaa     2640

gggtgtgaaa aagtcagtga tgctccccct ttctactcca gatcctgtcc ttcctggagc     2700

aaggttgagg gagtaggttt tgaagagtcc cttaatatgt ggtggaacag gccaggagtt     2760

agagaaaggg ctggcttctg tttacctgct cactggctct agccagccca gggaccacat     2820

caatgtgaga ggaagcctcc acctcatgtt ttcaaactta atactggaga ctggctgaga     2880

acttacggac aacatccttt ctgtctgaaa caaacagtca caagcaaagg aagaggctgg     2940

gggactagaa agaggccctg ccctctagaa agctcagatc ttggcttctg ttactcatac     3000

tcgggtgggc tccttagtca gatgcctaaa acattttgcc taaagctcga tgggttctgg     3060

aggacagtgt ggcttgtcac aggcctagag tctgagggag gggagtggga gtctcagcaa     3120

tctcttggtc ttggcttcat ggcaaccact gctcaccctt caacatgcct ggtttaggca     3180

gcagcttggg ctgggaagag gtggtggcag agtctcaaag ctgagatgct gagagagata     3240

gctccctgag ctgggccatc tgacttctac ctcccatgtt tgctctccca actcattagc     3300

tcctgggcag catcctcctg agccacatgt gcaggtactg gaaaacctcc atcttggctc     3360

ccagagctct aggaactctt catcacaact agatttgcct cttctaagtg tctatgagct     3420

tgcaccatat ttaataaatt gggaatgggt ttggggtatt aa                        3462


<210> 1063
<211> 1595
<212> DNA
<213> Homo sapiens

<400> 1063
gcccgccggt ccacgccgcg caccgctccg agggccagcg ccacccgctc cgcagccggc       60

accatgcgcg agatcgtgca catccaggcg ggccagtgcg gcaaccagat cggcgccaag      120

ttttgggagg tcatcagcga tgagcatggg atcgacccca caggcagtta ccatggagac      180

agtgacttgc agctggagag aatcaacgtg tactacaatg aggctgctgg taacaaatat      240

gtacctcggg ccatcctggt ggatctggag cctggcacca tggactctgt caggtctgga      300

cccttcggcc agatcttcag accagacaac ttcgtgttcg gccagagtgg agccgggaat      360

aactgggcca agggccacta cacagaggga gccgagctgg tcgactcggt cctggatgtg      420

gtgaggaagg agtcagagag ctgtgactgt ctccagggct tccagctgac ccactctctg      480

gggggcggca cggggtccgg gatgggcacc ctgctcatca gcaagatccg ggaagagtac      540

ccagaccgca tcatgaacac cttcagcgtc atgccctcac ccaaggtgtc agacacggtg      600

gtggagccct acaacgccac cctctctgtc caccagctgg tggaaaacac agatgaaacc      660

tactccattg ataacgaggc cctgtatgac atctgcttcc gcaccctgaa gctgaccacc      720

cccacctacg gggacctcaa ccacctggtg tcggccacca tgagcggggt caccacctgc      780

ctgcgcttcc cgggccagct gaacgcagac ctgcgcaagc tggcggtgaa catggtgccc      840

ttccctcgcc tgcacttctt catgcccggc ttcgcgcccc tgaccagccg gggcagccag      900

cagtaccggg cgctcacggt gcccgagctc acccagcaga tgttcgactc caagaacatg      960

atggccgcct gcgacccgcg ccacggccgc tacctgacgg tggctgccat cttccggggc     1020

cgcatgtcca tgaaggaggt ggacgagcag atgctcaacg tgcagaacaa gaacagcagc     1080

tacttcgtgg agtggatccc caacaacgtg aagacggccg tgtgcgacat cccgccccgc     1140

ggcctgaaga tgtcggccac cttcatcggc aacagcacgg ccatccagga gctgttcaag     1200

cgcatctccg agcagttcac ggccatgttc cggcgcaagg ccttcctgca ctggtacacg     1260

ggcgagggca tggacgagat ggagttcacc gaggccgaga gcaacatgaa cgacctggtg     1320

tccgagtacc agcagtacca ggacgccacg gccgacgaac aaggggagtt cgaggaggag     1380

gagggcgagg acgaggctta aaaacttctc agatcaatcg tgcatcctta gtgaacttct     1440

gttgtcctca agcatggtct ttctacttgt aaactatggt gctcagtttt gcctctgtta     1500

gaaattcaca ctgttgatgt aatgatgtgg aactcctcta aaaattacag tattgtctgt     1560

gaaggtatct atactaataa aaaagcatgt gtaga                                1595


<210> 1064
<211> 4968
<212> DNA
<213> Homo sapiens

<400> 1064
agccgcgccc gccagcgccc tcggtgggca cagccacccg gagcggcgcg ggtgccggga       60

gctgggcgac gcgcccctcc tgccccggct gcgctgttgc ccgggcggcc gacctccgtg      120

cgtgagcgcc ggcaggcacc ttgcgcgcgc ggaacctgct gacatggcca agcatggagc      180

cgacgagcca tcctccaggt cagggagtcc ggacagggaa ggtagggcct ctgaggacag      240

atcgctgctt catcagaggc tggctgtccg ggagctcatc gacactgagg tctcctactt      300

gcacatgctc cagctctgtg cctctgacat caggagccgc ctccagcagt tgccgcaggg      360

agatctggat gtcctgttct caaacattga tgatatcatc aaagtgaaca gcagattcct      420

ccatgatctg caggagacag cctccaagga agaggaacaa gtgcagctag ttggtaacat      480

atttctggaa ttccaagagg agttggagca agtctataag gtctactgtg ccagctacga      540

ccaggccttg ctactggtgg acacgtaccg gaaggagccg gagctgcagc ggcacatcca      600

gggcatcgtt gaggcggtgg tgccgcaagc tggatcttca ggcctcagtt tcttgctggt      660

aattcctctg cagaggatca ccaggtaccc actgctgctg cagaaaatcc tggagaacac      720

agtccctgat gccagtgcct atcctgtcct tcagagggct gtctctgccc tccaggacgt      780

gaacaccaat atcaatgagt acaagatgcg caaggaagtg gcctccaagt acaccaaggt      840

agagcagctg accctccggg agcggctggc ccgcatcaac acacacaccc tctccaagaa      900

gaccacccgg ctgagccagc tgctgaagca ggaggcgggg ctgatcccca ggacagaaga      960

caaggaattt gatgatttag aagagaggtt ccagtgggtg tctctgtgtg tgactgagct     1020

gaagaacaac gtggctgctt acctggacaa tctgcaggct ttcctctact tcaggccgca     1080

cgaatacaat ctggacatcc ccgaggggcc tgcagtgcag tattgcaatt tggcaagaga     1140

ccttcacctt gaggccttcc tgaaatttaa gcaacggcta gaaggcctgg tgtggcagcc     1200

actgtgcagc ctggccaaag ccctgcttgg ccctcagaac ctgatcaaga agcgtctgga     1260

caagctactg gactttgagc gggtggaaga gaagctgctg gaggtgggca gtgtgaccta     1320

ccaggaggag gccgcccggc acacatacca ggcactcaac tcgctgctag tggctgagct     1380

cccacagttt aaccagctgg tcatgcagtg gctgggccag atcatgtgca cattcgtgac     1440

cctccagagg gaccttgcaa agcaagtgct gcagagggca gagggaagca tggcccagct     1500

gccccaccac cacgtcccag agcctgcctt caggaagctg gtggaggacg cactgggccg     1560

gacgagtaac cagcttcgct cctttcaaga gacctttgag aaagtgcagc cacctcccac     1620

cacacaaccg ctccttccag ggtctgaacg ccaggtgcag gctctcctga gcaggtatgg     1680

ccctgggaag ctgtaccagg tgacaagcaa catcagtggg actgggactc tggacctgac     1740

tctgcctcgg ggccaaatcg tggccatcct tcaaaacaag gacaccaaag gcaacagcgg     1800

ccgctggctg gtggacaccg ggggacatcg tgggtatgtg ccggctggga aactacagct     1860

gtaccatgtg gtccccagtg cagaggagct cagaaggcag gcggggctga acaaagaccc     1920

ccgatgtcta acaccggagc ccagcccagc tctagtgccc tctattccca ccatgaacca     1980

ggtcatagcc gcgtaccctt ttgtggccag aagcagccat gaagtgagcc tgcaggcagg     2040

ccagcctgtg accatcctgg aggcccagga caagaagggg aaccctgagt ggagcctggt     2100

ggaagtgaat ggacagaggg gttatgtgcc ttctggcttc ttggccaggg ctcggagccc     2160

agttctgtgg ggctggagtc tgccctctta gggtaccctc tttggagcct acattgccaa     2220

atgatggggg aggcttagag gctctgaccc tggggggaaa agaagcaaag gaaaggtgga     2280

ggtggaaggg aagaccaggc cagggtgggt gaagcacact caggaggcag ccagaagaca     2340

tgggcgggcc tcgcagagtg cttggtgtgg tgggggcaca ggaggctcca gccaggactg     2400

ctcattatgt ctgcataaag aactcattcc gacctggggt cacaatgcac ttggacagca     2460

ggtcacagct gattggccag gactctccat aggttatggc cagtcttagc tgtgcctgca     2520

tccgggcctg cctgtgggcg tgggtcacac gggataatgt tacctgcgtg ctgtgtggtt     2580

gcaggaagcg ggttctggag gagtccagaa ctgcctggtc agacagttca cttcctacac     2640

atggtatcag gagacatcat aaccaatgag tcagctttta tttctctatg ctggaagctg     2700

agtttatctt gggcagtgac ccactgggag ccctctcaag tggggaagcc atggatttat     2760

cggtgtagca gagaggttcc caagactctt gactggtcct gggagtgggt gtgaccaagt     2820

catagttctg gaatgtgtgt aggcaaattc agaggctgtt ccagggaaga ggggattttg     2880

atactgtgtt aggtggggtg tgtgaggctg ttggcagcag gtgaacagct actgctgtgt     2940

tctcaggact agggaacaaa ggggtatgca aatcatagag gaaactctgg gaaggcggtg     3000

ataaggcctg gtgggtgggg aggttaggga atggcttgct ttcctgtttc tggttagaag     3060

gggagccagg gggaaccccc agtggtttca ggtggcccct gaggtcctgg aggcagccgt     3120

ggatgtgatg caattggctg tgggacctta gatgtaggac acaacttcag tgttcccatc     3180

cagaaagacc tcactcacag ggttgtgctg agaatgacgt ggggctaagc atgcagagct     3240

ccctgtaaac tgtgaagtgt gatacaaatg taaatgacag cagtgatctc ggggtggccc     3300

ccggcatgct gccctccccc acgcccatgc ctgtggcagc aaaccttgtt catcagtata     3360

gctttctttc ctgtaaccca ggatctacct tggggggctt ctcaatactg cattctatgt     3420

agccagcctc tttaacttgg taagtgagcc accccattct agaacctgga aattggagcc     3480

cctcaaaaac agttcctgtt caaggaggac tgacctgctg gggcaatgtt gggtgcagtg     3540

cagtccctgc ttggggtggt catgtctagg ctgttgctct gggcaaagat aagttgcaag     3600

attcacagaa atgggaaaat gtgaccaagt gtgatcttaa caactgacaa agtttgtaac     3660

caacccaagt tagaatgtgt gtcaaacagg aggtagttta gatatgcttc caagaacatg     3720

tctgtgttat aaccatagtg cctaagcagt gagctctggt ttttgaaggg cttttaagaa     3780

atatatacat gtctgtgtca gtctataact tgcctcctct gggcctgtta aagcatgaag     3840

actgcatgac acaagagaaa tgcaagccct acggttcctt tctcagcagc gaattcactt     3900

gagaggatgc tcttgactca ttctctctgc tctttcctgc tcagatttct gataaaaata     3960

gagagcatag gggaacagat aatgaaatag gaaacccact cgtgggttcc acagatacct     4020

accgaaggcc tactgtgtgc tagaattgta gctcaggagt tctcagtgta gctgctcact     4080

gaagttacca tggcaggttt caactggcag aatccaggct ccgtcccacc cagagattct     4140

gatgaaattg gtttagggtg tggctcgggc ctcaggaatt cagaaagctt cccaggtgct     4200

tccaatgtgc agccagggtt agggacctct accctagaca caaagtattg gacagataga     4260

cctggtgcca gagatggcca tgagctgtaa gctaggacgt gccccacctg agctctgcac     4320

tagctagttc aaacaggcgc tttaaaggca gtgtgaaagg ggacagcctg ttctgccagg     4380

tctcagaatg tatatttatt aagtgccatt aaaagggacc tgaacaaaat tggatgtctt     4440

gtaggcataa gggaggaaaa taaaatatac ttggaaccaa gtctatgtca tgaagggaaa     4500

ataaaaatgt attcagtagc acgtgggtta tggtttctca tagaccaggg gataagatta     4560

aaagtcactg aagagtggga aaatgcatgt tgagaagatg agaatggcct gtattttctc     4620

caggggaatc tgtgtaatgt gccttttccc tctccaaatg cctagaacca tggcactgtg     4680

tcttatttat ttaaccgttg ggctgtctca tactaaactt gcaaagatat ttgcctatga     4740

actgaacaag acttccagga gttgaagtct ggttcacaag ggtacccctt gcctcctgtg     4800

atggagtgag aactcttaaa cccctcaggc cccaactcag ttgtggagat gaggacaaga     4860

ttacaatatc aaaagaaaga tgaatgaatt cttggttaat atgacgaacc ccagctcaat     4920

gagtaactga tgtgaactgc tgggaataaa ggacttcaaa gatggaaa                  4968


<210> 1065
<211> 3795
<212> DNA
<213> Homo sapiens

<400> 1065
gagttccgta ttctagttct gtgtgatctg atctttacct tcccttcctt ggatccctgt       60

gcacctactg gagccaggtt actctgggtc ctggacctga ctgcctcatt ctggaggctt      120

ccagacagcc acagttagtg cccaaacctg agaggatggc ttcagatgga gcatctgcat      180

tgccgggacc ggatatgagc atgaaaccta gtgccgcccc gtctccatcc cctgcacttc      240

cctttctccc accaacttct gacccaccag accacccacc cagggagcca cctccacagc      300

ccatcatgcc ttcagtattc tctccagaca accctctgat gctctctgct ttccccagct      360

cactgttggt gacaggggat gggggccctt gcctcagtgg ggctggggct ggcaaggtca      420

ttgtcaaagt caagacagaa ggggggtcag ctgagccctc tcaaactcag aactttatcc      480

ttactcagac tgccctcaat tcgactgccc cgggcactcc ctgtggaggc cttgagggtc      540

ctgcacctcc atttgtgaca gcatctaatg tgaagaccat tctgccctct aaggctgttg      600

gtgtcagcca ggagggtcct ccaggccttc cgcctcagcc tccaccacca gttgctcaac      660

tggtccccat tgtgcccctg gaaaaagctt ggccagggcc acatgggaca accggggaag      720

gaggtcctgt ggccactcta tccaagcctt ccctaggtga ccgctccaaa atttccaagg      780

acgtttatga gaacttccgt cagtggcagc gttacaaagc cttggcccgg aggcacctat      840

cccagagtcc tgacacagaa gctctttcct gttttcttat cccagtgctt cgttccctgg      900

cccggctgaa gcccactatg accctggagg agggactgcc attggctgtg caggagtggg      960

agcacaccag caactttgac cggatgatct tttatgagat ggcagaaagg ttcatggagt     1020

ttgaggctga ggagatgcag attcagaaca cacagctgat gaatgggtct cagggcctgt     1080

ctcctgcaac ccctttgaaa cttgatcctc tagggcccct ggcctctgag gtttgccagc     1140

agccagtgta cattccgaag aaggcagcct ccaagacacg ggccccccgc cggcgtcagc     1200

gtaaagccca gagacctcct gctcctgagg cacccaagga gatcccacca gaagctgtga     1260

aggagtatgt tgacatcatg gaatggctgg tggggactca cttggccact ggggagtcag     1320

atggaaaaca agaggaagaa gggcagcagc aggaggagga agggatgtat ccagatccag     1380

gtctcctgag ctacatcaat gagctgtgtt ctcagaaggt ctttgtctcc aaggtggagg     1440

ctgtcattca ccctcaattt ctggcagatc tgctgtcccc agaaaaacag agagatccct     1500

tggccttaat tgaggagcta gagcaagaag aaggactcac tcttgcccag ctggtccaga     1560

agcgactcat ggccttggaa gaggaggaag atgcagaggc gcctccaagt ttcagtggcg     1620

ctcagttgga ctcaagtcct tctggttctg ttgaggatga agatggggat gggcggcttc     1680

ggccctcacc tgggcttcag ggggctgggg gcgccgcttg ccttggaaag gtttcttctt     1740

caggaaaacg ggcaagagaa gtgcatggtg ggcaggagca agccctagat agccccagag     1800

ggatgcacag ggatgggaac actctgccat cccccagcag ctgggacctg cagccagaac     1860

ttgcagctcc acagggaact ccgggaccct tgggtgtgga gaggagaggg tctgggaagg     1920

ttataaacca ggtatctcta catcaggatg gccatctagg aggcgctggg cctcctgggc     1980

actgcctggt ggctgatagg acttcagagg ctctgcccct ttgttggcag ggaggcttcc     2040

agcctgagag cactcccagt ttggatgctg gacttgcaga gctggctcct ctgcaaggac     2100

aagggttaga aaagcaagtc ctgggattgc agaaaggaca acaaacaggg ggtcgtggag     2160

tgcttcctca agggaaggag cctttagcag tgccctggga aggctcttca ggagccatgt     2220

ggggagatga cagaggtacc cccatggctc agagttatga tcagaatcct tcccctagag     2280

cagctgggga gagggacgat gtctgtctca gcccaggagt ttggctgagc agtgagatgg     2340

atgctgtagg cttggagctg cctgtacaaa tagaggaggt catagagagc ttccaagttg     2400

agaagtgtgt aactgagtat caggaaggct gccagggact gggctccagg ggcaacattt     2460

ccctgggtcc tggagaaacc ctagtacctg gggatacgga gagcagtgtg attccctgtg     2520

gaggcacagt tgcggcagct gccctagaaa agagaaacta ttgcagcttg ccaggacctt     2580

tgagggccaa cagcccaccc ttgaggtcca aagaaaatca agaacagagc tgtgaaaccg     2640

tagggcatcc cagtgatctg tgggcagaag gttgcttccc attgctagaa agtggtgatt     2700

ccacactggg gtcttccaaa gaaacccttc cacccacatg ccaaggcaat ctccttatca     2760

tggggactga ggatgcctcc tccttgcctg aagccagtca agaggcaggg agcagaggca     2820

attccttttc tcctctgttg gaaaccatag aacctgtcaa catactagat gttaaagatg     2880

actgtggcct ccaactaagg gtcagcgagg acacctgccc actgaatgtt cattcttatg     2940

acccccaagg agaaggcagg gtggatcctg atctgtccaa gcctaaaaac cttgctcctt     3000

tacaagagag tcaggagtct tacacaactg ggactcccaa agcaacatct tctcaccagg     3060

gccttggaag cactttgcct agaaggggaa ccaggaatgc catagttccg agagaaactt     3120

ctgttagtaa aacacacagg tcagcagaca gggccaaagg aaaggagaaa aagaaaaagg     3180

aagcagagga agaggatgag gaactctcca actttgctta cctcttggcc tctaaactta     3240

gcctctcacc aagggagcat cccctcagtc ctcaccatgc ctcaggaggt cagggcagcc     3300

agagagcatc ccacctgctc cctgctggag caaaaggccc cagcaaactt ccatatcctg     3360

ttgccaagtc tgggaagcga gctctagctg gaggtccagc ccctactgaa aagacacccc     3420

actcaggagc tcaacttggg gtccccaggg agaaacccct agctctggga gtagttcgac     3480

cctcacagcc tcgtaaaagg cggtgtgaca gttttgtcac gggcagaagg aagaaacgac     3540

gtcgtagcca gtagggagca gcgggaccat ctgaccccac ttgccagtcc ctaaaggtgg     3600

gtgccccaga gtagattcca cccctgctgc ccaccaatgg agaatcccaa tgttgaatct     3660

catcccaatg ttgttttgtt gttctgcaaa agtggcaagc atggagagag aggtcagact     3720

ggctaggctg cagggggaat tacctttgga aggagctata tagaaaaaaa atgaataaag     3780

tgttttgttg gaaaa                                                      3795


<210> 1066
<211> 997
<212> DNA
<213> Homo sapiens

<400> 1066
gcagagaacg aatacgctcc gttttaattc agtggcctgg gctacatggg atatttagga       60

cagactatct ctctgagaca gaaaaacaag ggaggaggca gtatgaaaga atgtattctc      120

gctaaattcc agtttctaaa ggatgtgtaa gaaaccagag gtaaaggtct cgcgatatct      180

taagacatcc ggcgtagtac gcttcagtga gccacagcgc tagagaagta ggagaagctc      240

gcgagatctg tgccgttgcc gaggagacta ggagggggag gagaggggat ctcgcgaaag      300

gaaagaggtc gggagcgctc gcgagatctc ggaccaccca acctgaaagg tgcttaggaa      360

gttgaaaggc ccagaggagg cctccgggca aatggccgga gctggaccga ccatgctgct      420

acgagaagag aatggctgtt gcagtcggcg tcagagcagc tccagtgctg gggttagcac      480

gggctctggt tctgggactg aggggcagtc aagcagcaag atggaggggg tggggaactg      540

cagctcccgg cagcctctgg gctttgtgtg agtgccccgc gggctgccgg gagctgtggt      600

tccgcgggcg ggcagcctgg gctgcgcggt ctgagcgctt gttacacccc gcgcaggatt      660

cggacggaga gcgcgaggac tcggcggctg agcgcgcccg acagcagcta gaggcgctgc      720

tcaacaagac tatgcgcatt cgcatgacag atggacggac actggtcggc tgcttcctct      780

gcactgaccg tgactgcaat gtcatcctgg gctcggcgca ggagttcctc aagccgtcgg      840

attccttctc tgccggggag ccccgtgtgc tgggcctggc catggtaccc ggacaccaca      900

tcgtttccat tgaggtgcag agggagagtc tgaccgggcc tccgtatctc tgaccacgat      960

ggcgcttacc tttcagactt cattaaactt atgaccg                               997


<210> 1067
<211> 1161
<212> DNA
<213> Homo sapiens

<400> 1067
aaactcaaga actttactct cttggaaacc caaatagatc cttcaccctc tgacaccatg       60

gtcaactcct gttgtggctc cgtgtgctct gaccaaggct gtggccaaga cctctgccag      120

gagacctgct gctgccccag ctgctgtcag accacctgct gcaggaccac ctgctaccgc      180

cccagctaca gtgtgtcctg ctgctgcaga ccccagtgct gccagtctgt gtgctgccag      240

cccacctgct gtcgccccag ctgctgtgtg tccagctgct gcaagcccca gtgctgccag      300

tctgtgtgct gccagcccac ctgctgccac cctagctgct gcatctccag ctgctgccgc      360

cccagctgct gtgtgtccag ctgctgcaag ccccagtgct gccagtctgt gtgctgccag      420

cccaactgct gccgccccag ctgcagcatc tccagctgct gccgcccctc ttgctgtgaa      480

tccagctgct gccgcccctg ctgctgcctg cgtccagtct gtggccgagt ctcctgccac      540

accacttgct atcgcccagc ctgtgtcatc tccacctgcc cccgccccgt gtgctgcgcc      600

tcctcttgct gctgagccca ctgccctggc tcatctctcc cttcaccgct ggtccacaaa      660

tgtagaccat tcttctgtgc tgaatattag gacacatgga gtgggattta tgtcattcag      720

cagggtggac ctcatgtatc caatgagccc atcaccatcc cgctgactct gtgagaacat      780

tctggttcat tttaaactcc ctcccttgct ttctttttct tccagtcatg gcaccaaata      840

cgaattaatt tgtaatccac tagctaagaa attattccaa tcctctaaat tcctcatttt      900

ttaaaatcat tttgagccta cagaatatcc ttcccaatta ggtacacatt atctcccttt      960

caaacatact atttgtctgt cagcctttca gtcattcttt tcttttggaa aggtaggagg     1020

ctgcccctcc cgtgctctcc cgctttctcc ctgctctctc tttctctcac tgttcaagtt     1080

tgtcagaatt tttctatttt attagttctt tatctttatt gtgttcacaa aatatattgt     1140

attaaacttt tcatttagaa a                                               1161


<210> 1068
<211> 440
<212> DNA
<213> Homo sapiens

<400> 1068
cacctcaact gaaatctaac ctcctgaaat catgtgttgc aactactaca gaaactgctg       60

tgggggctgt ggatatggct ctggctggag ttccggctgt ggatatggtt gtggctatgg      120

ctgtggatac ggctctggct gtagatatgg ctctggctat ggaactggct gtggctatgg      180

ctgtggatac ggctctggct gtggatatgg ctgtggatac agctctagct gctgtggcta      240

ccgaccactt tgctacagaa gatgctattc ctcttgctac taatcatcac tacaggtcat      300

ccttggcttt gcaatgacct ctccaagatc aagttcaatt gaaatctccc ctacccatta      360

tcttcacatc taagtaaagg ttgactatgg tcacctgact atctgaatgc atataagaga      420

agctgttggc agtggatgga                                                  440


<210> 1069
<211> 1281
<212> DNA
<213> Homo sapiens

<400> 1069
aacagggctt cgtcttcttt gcagagccat gggcagcagg aagaaggaaa ttgccctgca       60

ggtcaacatc agcacccaag agctttggga ggaaatgctc agttccaaag gactaactgt      120

tgttgatgtc tatcaaggct ggtgtggccc ctgcaaacct gtggtgagcc tcttccagaa      180

gatgaggatc gaggtcggcc tggaccttct gcactttgca ttagcagagg cagatcgtct      240

tgatgtcctc gaaaagtaca gagggaagtg cgagccaacc tttctgtttt atgcaggagg      300

agaactggtg gctgtggtta gaggagcaaa tgccccactg ctgcagaaaa ccatcctaga      360

ccagctggag gccgaaaaga aagtgctggc tgaaggcaga gaacggaaag tgattaaaga      420

tgaggctctt tctgatgaag atgaatgtgt ttcccatgga aagaataatg gtgaagatga      480

ggacatggtt tcatcagaga ggacctgtac cttggccatc attaaaccag atgcagtggc      540

ccatggaaag actgatgaga ttatcatgaa gattcaggaa gctgggtttg aaattctaac      600

aaatgaagag agaaccatga cagaggcaga agtgcgactt ttctaccaac acaaagctgg      660

agaggaggca tttgagaagc tggtacatca catgtgcagt ggaccaagcc acctcctgat      720

cctcaccagg actgagggct tcgaggacgt ggtcactacc tggcgaaccg tcatgggccc      780

ccgtgacccc aatgtggcca ggagggagca gccagaaagt ctccgagctc agtacggcac      840

agaaatgccc ttcaatgccg tccatggaag ccgggacaga gaagatgctg acagagaact      900

ggcattgctc ttccccagtt tgaaattttc agacaaagat acagaagccc ctcagggcgg      960

tgaggctgaa gcaacagcgg ggcccactga ggcgctttgc tttcctgagg atgtggattg     1020

agatggctgt gctgctcttc cagagcacgt gaccaggggt ctactgcaca aaacagacct     1080

ccggaatcgg aacttactct tttgagtacc aatacttttt ggtttagctg tcttttgtag     1140

acaatgaaaa taatatggct gggcgcagtg actcacacct gtaatcccag cactttggga     1200

ggccgaggca ggtggatcac ctgagattag gagtttgaca ccagcctagc caacatggtg     1260

aaaccctgtc tctactaaaa a                                               1281


<210> 1070
<211> 606
<212> DNA
<213> Homo sapiens

<400> 1070
atggtcagct cctgttgtgg ctccgtgtgc tctgaccagg gctgcggcca agacctctgt       60

caggagacct gctgccgccc cagctgctgt gagaccacct gctgcaggac cacctgctgc      120

cgccccagct gttgtgtatc cagctgctgc aggccccagt gctgccagtc tgtgtgctgc      180

caacccactt gttcccgccc cagctgctgt cagaccacct gttgcaggac cacctgctac      240

cgccccagct gttgtgtgtc cagctgctgc aggccccagt gctgccagcc tgcgtgctgc      300

caacccactt gctgtcgccc ccctaggtgc tgcatctcca gctgctgtcg ccccagctgc      360

tgtgtgtcca gctgctgcaa gccccagtgc tgccagtctg tgtgctgcca gcccaactgc      420

tgccgcccca gctgcagcat ctccagctgc tgccgcccct cttgctgtga atccagctgc      480

tgccgcccct gctgctgcgt gcgtccagtc tgtggccgag tctcctgcca caccacttgc      540

tatcgcccaa cctgtgtcat ctccagctgc ccccgcccct tgtgctgtgc ctcctcttgc      600

tgctga                                                                 606


<210> 1071
<211> 1036
<212> DNA
<213> Homo sapiens

<400> 1071
gcggggcggc ggggcggccg gcggcggcca tgggagatat cccagccgtg ggcctcagct       60

cctggaaggc ttctccaggg aaagtgaccg aggcagtgaa agaggccatt gacgcagggt      120

accggcactt cgactgtgct tacttttacc acaatgagag ggaggttgga gcagggatcc      180

gttgcaagat caaggaaggc gctgtaagac gggaggatct gttcattgcc actaagctgt      240

ggtgcacctg ccataagaag tccttggtgg aaacagcatg cagaaagagt ctcaaggcct      300

tgaagctgaa ctatttggac ctctacctca tacactggcc catgggtttc aagcctcctc      360

atccagaatg gatcatgagc tgcagtgaac tttccttctg cctctcacat cctcgagtgc      420

aggacttgcc tctggacgag agcaacatgg ttattcccag tgacacggac ttcctggaca      480

cgtgggaggc catggaggac ctggtgatca ccgggctggt gaagaacatc ggggtgtcaa      540

acttcaacca tgaacagctt gagaggcttt tgaataagcc tgggttgagg ttcaagccac      600

taaccaacca gattttgatc cgatttcaaa tccagaggaa tgtgatagtg atccccggat      660

ctatcacccc aagtcacatt aaagagaata tccaggtgtt tgattttgaa ttaacacagc      720

acgatatgga taacatcctc agcctaaaca ggaatctccg actggccatg ttccccataa      780

ctaaaaatca caaagactat cctttccaca tagaatactg aggacgcttc cccttccttg      840

tttctgctca gcccagatgc acagacacta ttggcaatgt tgaccctcct ctgtcatcac      900

agcgccaggg cagctgtgcc tgggacagga gccacacagt cagaggggga tgtaagagcc      960

accttctctg acaaatctgg agaattgagt gtgttctaag tgaaggcaat ggggtttctc     1020

caagacagcc tgtgtg                                                     1036


<210> 1072
<211> 330
<212> DNA
<213> Homo sapiens

<400> 1072
gcattgaact gaatctctag tccctgacac catgagatac tatggcagct actacagagg       60

cctgggatat ggctgtggag gctttggtgg tctgggctat ggctgtggct gtggaggcta      120

cagatatggc tctggctatg gaggctatag atatggctgc tgccgcccat catgccgtga      180

aggatatgga ttctctggat tctactaaaa aacttgctga ttctcatact ctaactccaa      240

gatcttgccc gtatgcttca gcaaggcgaa cacttttctc aatgtagaga aaatacctac      300

cattttttgg cttcatgctc cagaaggaac                                       330


<210> 1073
<211> 394
<212> DNA
<213> Homo sapiens

<400> 1073
gcaaacccaa ctcactatct ctgacaccgt gagctactag ggcagctact gtggaggtct       60

gggctatggc tgtggaggct ttggtggcat gtgctatggc tacggctgtg gatgtggcag      120

cttctgcaga ctgggctatg gctgcggcta tgaaggatgc agatatggtt gtggccacag      180

aggctgtgga gatggctgct gctgcccatc atgctacaga agatatagat tcactggctt      240

ctactaagct gctgctctag tgatgcagca tctgttattt tgaagggatt taaaaacaag      300

ttacttactt ctaagataca atgggggtaa aggtgtaaat gtgtaaatgc tcccattcca      360

aagggagaaa ttgaccaaaa caaaggggct ataa                                  394


<210> 1074
<211> 310
<212> DNA
<213> Homo sapiens

<400> 1074
aacaactcac cactcctgac gccatgagct actatggcag ctattacaga ggcctgggct       60

atggctgtgg aggctttggt ggcctaggct atggctatgg ctgtggatgt ggcagcttcc      120

gcagactggg ttatggctgt ggctttggag gcaacggata tggctactgc cgcccatcat      180

gctatggagg atatggattc tcaattctac tgaaatccta ccctgaggac acgatatcag      240

aggtcataag aagatcattc aatttaacca aatattgagt caaacaaggg cacactagat      300

caatccaaga                                                             310


<210> 1075
<211> 494
<212> DNA
<213> Homo sapiens

<400> 1075
atgagctact acggcagcta ctatggaggc ctgggctatg gctgtggagg ctttggtggc       60

ctgggctatg gctatggctg tggatgtggc agcttccgca gactgggttc tggctgtggc      120

tatggaggct acggatatgg ctctggcttt ggaggctatg gatatggctc tggcttcgga      180

ggctacggat atggctgcta ccgcccatca tactatggag gatatggatt ctctggattc      240

tattaaacta ctgccccagc aacacaatgt gtgaaattat aagaggactt tcccagagct      300

gacttcaatc attggacaac aaagatcatg ctggagctat ttgcacaaaa gaatttaaca      360

tctcagaatt tcaggcaatt ttttttctct gtatacccac atctctataa taatcctagt      420

attctctact tttgctttta aagctgattg aattatctgt ttatcttcca ataaaacatt      480

ctattttcaa acac                                                        494


<210> 1076
<211> 474
<212> DNA
<213> Homo sapiens

<400> 1076
cacacacgct cctcactgca aatcacctga gctcagaact cctgttaaca tgtcttacaa       60

ctgcagctct ggaaacttct cctcctgctg ttttggaagt tacctgaggt atccagtttc      120

cacttataat ttgttctacc ccagcaatgc catctattct ccaaatacct gccaactggg      180

ctcctctctc tacaatggct gtcaggagac ctactgtgag cccaccagct gccagacatc      240

ctgcactttg gccagatcct atcagacatc ctgttactgc ccaaagaatt ccatcttctg      300

cagtccccgc cagactaact acataagatc ccttggatgt ggaaacactg gccttggatc      360

tcttggttgt ggaagcactg gcttccaatc tctggactgt gggtccagct tctaccaccc      420

aactaccttt tcatccagga atttccaggc aacttgttac taaccagcct ttgg            474


<210> 1077
<211> 645
<212> DNA
<213> Homo sapiens

<400> 1077
tgaactccca tctctcatca gcatgtccta caactgctgc tctagaaact tctcctcccg       60

ctcctttggg ggctacctgt actacccagg ctcctacccc agcagcctgg tctacagcac      120

tgccctctgc tctcccagca cctgccagct gcgttcctct ctctacaggg actgtcagaa      180

gacctgctgg gagcccgcca gctgccagaa atcctgctac cgccccagga cctccatcct      240

ctgctgtccc tgtcagacga cttgctctgg atctctaggc tttcggtcca gcagctgtcg      300

ctcccagggc tatggatcta ggtgctgcta ctcgctggga aatggatcca gtggcttcag      360

attcctgaaa tatggaggct gtggttttcc ttccctgagt tacggatcca gattctgcta      420

cccaaactac ttggcttctg gagcctggca gtcttcttgt tacagaccaa tctgtggatc      480

tcgcttctat caattcacct gctaaatttc tagatccttt tgagtattgg gatcaaagtc      540

tctactgaat gcagccatta ttttcattct tgccagatcc caatatcttt ttattcttcc      600

accaccagct tcttgcatga ccaacttctg gcagactgcg aaatt                      645


<210> 1078
<211> 932
<212> DNA
<213> Homo sapiens

<400> 1078
ctctattacc tgcaagcagg agcagtggcc aactcctgga aacagctctg ccccaggttg       60

cactctcgcc ctttgttcaa gacaatctcc gggaaggggc agagcagaag gtggtattca      120

tcacaggacg agtccaccca ggggaaacac cctcatcatt tgtgtgccaa gggatcattg      180

acttccttgt aagccagcac cctattgcct gtgtcctccg ggaatacctg gtcttcaaga      240

tcgcaccaat gctcaatcct gatggagtct acctgggcaa ttacaggtgt tctctgatgg      300

gatttgatct gaatcgtcac tggctggatc cctctccatg ggtccatcct accctgcatg      360

gagtgaaaca actcatcgtc cagatgtaca acgacccaaa aacaagcctg gagttttata      420

ttgacatcca tgcccactcc accatgatga atggcttcat gtatggcaac atctttgagg      480

atgaggaacg gttccagagg caggccattt ttcccaagct cctctgccag aatgctgagg      540

acttctccta ttccagcaca tcctttaacc gggacgctgt gaaagcagga actggccgtc      600

gcttcctcgg tggactcctg gaccacactt cctattgcta caccctagag gtctccttct      660

acagctacat catcagtggc accacggctg ctgtgcccta cactgaagaa gcctatatga      720

agctggggcg gaatgtggca agaacctttt tggactatta tcggctgaac cccgtggttg      780

aaaaggtggc aattcccatg ccgagactgc ggaaagaaaa atcccctcct tacaagcacc      840

cactcctgcg gggcccagcc agcaactacc ccaacagcaa aggggacaag aagagctcag      900

tgaaccacaa agacccttca accccttttt aa                                    932


<210> 1079
<211> 966
<212> DNA
<213> Homo sapiens

<400> 1079
tctgaacaga agcccaccct ctacccctga caccatgacc cactgttgct ccccttgctg       60

tcagcctaca tgctgcagga ccacctgctg caggaccacc tgctggaagc ccaccactgt      120

gaccacctgc agcagcacac cctgctgcca gccctcctgc tgtgtttcca gctgctgcca      180

gccttgctgc cgcccaactt gctgtcaaaa cacctgctgc cagcccacct gtgtgaccag      240

ctgctgccag ccttcctgct gcagcacacc ctgctgccag cccacctgct gtgggtccag      300

ctgtgaccag agcagctcct gtgcacctgt gtactgcaga agaacctgct actaccccac      360

aactgtctgc ctgcctggtt gcctaaacca gagctgtggc tccaactgct gccagccctg      420

ctgccgccca gcctgctgtg agaccacttg cttccagccc acctgtgtgt ccagctgctg      480

tcagcctttt tgctgctgat caagtcccaa gagaaccacc atcctcacac aacaactttc      540

tgctcaactg acttatcttt tgggggacta atttaatttg ctgctgacag ccaccatgct      600

ctcacccaaa tttttatgaa ttctctacct gtttaaaatc ttgggaatct acttgaggga      660

gggcagaata cttcatcctg attctctttt tccttacact ttgtggatca tgtgccagct      720

tcgtgtgttc tcaattttga gtcatggtct cagctttgac tcaaaagtca agagcttcat      780

tctctgcttc taaggaattt aggtttctgc aactgatcaa taatctttgc aatcatattt      840

ttgttttcaa tatcctcctc atggttcttg tatccttctt tcttcttttc ataactttgg      900

gttatgtttc tgctaccagc agagattctt agctatatgt ttctgaataa actctgaacc      960

atcctc                                                                 966


<210> 1080
<211> 7289
<212> DNA
<213> Homo sapiens

<400> 1080
aaagcgtcct gggtattgta gtgtattgga gggaaggcgt cttggcgcct tctcttcgca       60

ccgttttccg gagactgtta gaggaagagt cgctttttcc tgcctcccag gctgcccagc      120

ggcgccggtt gccggggaac gcaggcgccg tggggaggga tggcgggagg atactgctta      180

ggtgctggag acggagttga gctggtgaag aagagctcgg gctcatcatg aaacaacgaa      240

aaggccaagg gtctgggggc agccgtgggc gcaaaaaaag aggtttaagt gacatttctc      300

catctacaag cctgccacct ctggttgaag gccagctacg ctgttttcta aaacttactg      360

ttaatagagt catatggaag attgcaaagc ctcccacttg tgtacttgtc cgagtgagat      420

ggtggggaga aacatcagat ggaaccctct tttgtcccag ggatgcattg cagactgaac      480

caaaagctgt gagaacaact acacgttacg ctattcgttg tggtccaaaa cagtttacct      540

cttatctaac agatatggct gtgctggtgc tggaagtaat caccaaactt gatggtcttc      600

caattggtag agttcagatc aatggactag ctcaactttc tccaacccat caaatcaatg      660

gattttttac cattgtttca tcaacgtcta agaaacttgg agaactccag gtctcacttg      720

ccctggaacc tctgtcagaa acttacgaca gctaccatcc acttcctacc actgacatga      780

cagaaaatgt gcttttatct aagcagggat tcagagagaa tactgaaccc agcagtaccc      840

agtttcaggt tccatcaagg cctcgcgaca tacataccat caaaattgat ggaaaagagt      900

tagcagccaa cagcagtaga tcaaccactc cgaggggaaa agaccatgta tgctttgcag      960

agaaccctga tacaataaag gattcttcct ttggactaca gcacagtctt aattcaggac     1020

agagtttaga gtctgtaact ctgaaaggca gagctccacg gaagcagatg tcccttctga     1080

acagttctga attccagcct caaattagaa cagttgccaa gagtcacagt gactcatgca     1140

ttctttcttc aaacaacctc cctaccaagg atcttctttc agctctgtta gaacaaggca     1200

ataaactgcg taatgccatg gtgatttctg caatgaaatc aagcccagag accagcatgt     1260

tgttggacca agttcatcct cctattaatg aagattctct tagagcatca acacagatca     1320

gagccttttc taggaatcgg tttaaagacc acattgaaga tcacctcctc ccttcaactg     1380

agaatacatt ttggagacat gacacaaaag ctgataccag agctatacag ctgctattag     1440

gcagtgctga attatcccaa ggcaatttct gggatgggct aggctctcct ccagattccc     1500

catctcctgg gagtgatgtg tattgcatca gtgagctgaa tgaccctcag tatgaccaga     1560

gtcttctgga gaatttattt tatacagcac ctaaatctga taccagcatc agtgatttcc     1620

tcagtgaaga ggatgatatc gtcccttcta aaaaaataag ccagtcaaca gctcttgcca     1680

gatcatctaa ggttctggag tcaagtgatc ataagctgaa gaagaggtca gcaggcaaga     1740

gaaatagaaa tttggttgaa caacagatgc tctcagaaac tccagaagat gcccaaacga     1800

tgacactaag tgtggataga ctggcccttt tgggtagaac acattcagtc agaatcatca     1860

tcgaaaccat gggagttcct ccagatagtc ctcagatgac ccctggcaaa aaaagctatg     1920

ctggtccacc acctaaggtg actacagcaa aaaagcgcac tttctttgta gaatatcact     1980

ttcctgtggg cttttcggaa agcggattgg gaaagacagc tttgatcact gaggttgttc     2040

gactcgcctc cagtaaaatt acagatggaa aggtgaagtt ccagcagcga tttgtgtttc     2100

cagtacagtt tggtggccca atgatagagc actggtggaa ttccaacctc actttccaaa     2160

tttatgtaaa gaaaactcca cagaaaaagc cagaagtcat tggatctgtg tcactttctt     2220

tgcgagctgt cattcaatca gagctgcttt ctttcagtga tcagcttcca gtgcaacaag     2280

aaaatggtca gtctccattt ggccccctca aggtaaccat ggagcttatt acagataaca     2340

aagatttcac tggtatcaat actaagttaa gtggcaacac ccattatacc ccactttgtg     2400

ctcctacaag tccaaataag gcactaccag aacttaacca agatatgacc tgtaccaaaa     2460

atccacaaaa cttaaaccaa attcatgagg aaactgcaaa gaaagcacag aacttggtgc     2520

tccccaaccg aaagtcacca agccctgtag caccacatcc ttcaaccttc gtagctacgc     2580

cagcctccca taatttagtc aatcagacaa atgggacaac aaaagagagt gctttgctgt     2640

tgcatgtgct gttgatggtg ccagatggga aagattttat tagtggagaa tctgagaaac     2700

aatcaccatg caatgtttat ttaaattgta aactcttcag cacagaggaa gtcaccagat     2760

ctgtcatcgc atggggcaca acacaaccgg tctttaactt ttctcaggtg attcctgtct     2820

ctctgtcttc caaatacctg gaaaggctta agaacaatgt gatggtaatt gaaacttgga     2880

ataaggtgcg gagcccagga caggacaagc tgctcgggct ggtgaaactt cccctccacc     2940

agttttacat gtcattcaaa gatgctaaga tttctcgcct gctgctggat gcccagtacc     3000

cagttgttgc tgtcgacagc tacatgcctg tgattgatgt gttttcaggc caccaaaatg     3060

ggagtcttcg agtcttttta gctatgggtt cttcaaatca aataatggca ctacaaagat     3120

taaagaatga agaaggaaca ctccctccct tcagccctag gccagcccat ttcctggacc     3180

agccaactgc agcatctgtt gctatggcag aggaccgagg aaatggactg atggagcact     3240

gctttgagat ccatatagag atggttaaag ggctagcccc tcttcaggca acagtctggg     3300

gagaagcaga ttgttatgtc cagtactact ttccagttca acactctcaa tccagtgtgc     3360

tgaaaggacc tgagttcctt gaaaatggaa ttactctgaa gcccttcaga actgcaacca     3420

cactctgtgt tccagatccc atctttaata gtgaacacca tcactctctc ctgttgccag     3480

ctgaggttcc agtgcaaagg ctcctactaa gtgctttctc tgcacagggc ctcgtgcctg     3540

gaggtggagt ccagtttgaa atctggtgca gatactatta tcctaatgtg agagaccaga     3600

aggtcgccaa aggaaccttg ccattatcaa ggatctgtgc tatggtaacc acccagcatc     3660

gtgaggatgt gggaatacag acctttaatc tccctttaac ccccaggatt gagaacagga     3720

aagaattgag gaaccagtca tcaggtttac tggatgtggg cctaaggtac aggcgtagtc     3780

caagaacagc agagggagtt cttgctgccc gaactgtttc catctcagtc cagattatca     3840

gagcctgtgg tctgcaagca gcagccaagg ctttggctga acgggaaccc gctctacagt     3900

ttagtgccac agtcggggtc aatgcctctg tcaccactca tctctccttc ctgccccagg     3960

gagaacagcg ccgaacccac cctgtggcct gttctttctg ccctgagttc tcccatcacg     4020

ttgagttcac atgtaacttg gtgactcagc actgtagtgg agaggcctgt ttcctagcag     4080

agttgttgga gtttgcagaa gttatttttg ctgtctatca tgaaaatacc aagtcagcaa     4140

gtgatataat cagtattgag tcatgcaaag agtatctgct tggagtagta aaagttccaa     4200

caaaagagct gctgatcaag agatctggga tcacaggatg gtatcctatc attttaccag     4260

aagacggggg cctacctcat ggcctggagc tcatgcagaa gatcgtgggt ggtctggagc     4320

tttcgatttc cttcacgcat cgtggagata gagaacgggt gttggaagct gctgagcatt     4380

tgggctggag ctttgagaac agcctgaaag attttgtcag aatggatgaa ggggagccag     4440

ccactgtcac catctccacc ccaaggctgt ggctgcccat ccattgtgtg ctgcttgctg     4500

gccacaacca cattcataag aatacatatt gctaccttcg ctacaagttc tatgatcatg     4560

aagccttttg gacccctctc aagaagccta aggaatctgt aaacaaaaag cagattatgg     4620

tcactttcaa ggcatccaaa agagcagaag tcaccagggg cccatcactg ctttggtact     4680

tcagggagga gaggctagag atccaagtgt ggcgagctta tggcaatgac agtgtggaga     4740

gaccccatca gacagacagc tggattggct cagcctatgt ggacctggcc agacttgggg     4800

agaggtcagc gaggacgcta actgtcagtg gtgtgtatcc tctgtttgga cgaaatgctt     4860

ccaacctctc aggagctgcc ttgcgagttc atgtggttct ttcctctctt tcctcacacc     4920

ttgagcccac tcatgagctg gactccatgg actgcagcag ccacagtgag tctgagcagc     4980

tccccagaag gaatgatgag gtccagctct ctccaccaga agtcatctcc tgccaccaga     5040

agtctcctgc ctccacccag gtcccctgca gcagcaccac agctgaagtc cgcctgacgc     5100

aggagggccc tgctgatttg gatggaacgt ttgcagtcag catcctagta gaaagagcaa     5160

tgcacttgag cttgaaaggg agccccttga cagagcggaa agtatcgata cccagttgtt     5220

gtgtatcctt tgcaacagcc gatgagtcat ctcctgtata cacccaagtg gttgaaaaca     5280

cagattcccc catctggaat tttcaacagc agtcaaggct atcaaaagag ctgcttctgg     5340

acccacaaca aaccctggtc ttcaaagttt ggcataaagg agatgaggag agggtgattg     5400

gctttgcctc ggtggacctc tccccacttc tctctggctt ccagtttgtc tgtggctggt     5460

acaacatcac agacttcagt ggagagtgcc aggggcagat aaaagttgct gtctcccctt     5520

tggagagttt gatacacttc aaagaagaaa ggcaagcaag gcgtggagtg gagacctcaa     5580

aatcactgat cccaatatac agtccctttt ccttccctgc ctctgatacg tatgctgcat     5640

tctccagcca catggcaagg cagaccctag accaacttgc tcatgcctcc tcaaaggagc     5700

ttgatttctc ctctcctggg agaagtgata ccacaagaag ccaagcatca cgccatgaag     5760

agcatgtgca gaacattcgc cggtttcatg aatccctgca tcttcaggga gaggcaccct     5820

tgccatgtga tgacaaactg accacatcac ctttgtcctc ccaaacctcc attctgactt     5880

ctctcaggaa gaatctgagt gagcttgatc agattcagag gtacttccgc cagaagctca     5940

ccaagccttt cctacccctc agccctcaga ctcaaacggc catctcacag caccaggaga     6000

gctgtaggga ccatcttggg ccaggtgcca gcagcctaga ccctgggagc cagtgtatcc     6060

tggagaaatc cagtaacctg gtgttgcaag tcagctcctt aatcacagat ctgcagacta     6120

tcaccaggga ttcgcaagca gctttgagtt ctcaccgagc caggagtaga agcaacaagg     6180

ccaccaccct cccagatgct caggacacag aagcactgca agaacgatgc acaatgccag     6240

atgagccatt ggtaagagct ccagataaag gcacagattc cccatcaccc cctcctctcg     6300

aagagacttc aaatggagga agaatgctcc atgagtccct gaggcatgca gtacccatta     6360

caaggatgca gagcagtgaa gacactgagg caggcccagc ctacagtgat gaggactatg     6420

aagaagacat cattgagccc aggaccttaa atgagatcac cacggtgaca gacaaaacta     6480

gcccttggtc tagtgtcata tcagacacaa gtgaggtcat cagccctcag cctgacgagg     6540

tgcagaggga aggcccctct tgtccttctc cagggccttt ctgcagagag gagcttatgg     6600

tcaaaagtag ctttctctcc agcccagaaa gggctgtcaa cccccacctg cctaggcagg     6660

gttctcctag ccaaagtctt gttgcttgtg agtgtgaggc ctctaaggcc agggttggtg     6720

gcgagtctgc ctcagccaac cctcagccca tcccatgccc aacactctca ggagctcaac     6780

agagcagcac gtttgttgga tggagctcac cacagacaga tcagaacaag gagcccaagt     6840

cagaggcccc agctgagaat gaagctgcca ccagtgagct cggtgactct gctgatagct     6900

tcaagaagtt gccgctaaat ctagcctccc agagcagaag ggaaaaccat aagggaccac     6960

ccatcgactc ctctgacatc aggcagaggc aggtgacaac tggatcagag acgtccacaa     7020

agcagagcct cctgctccca gggcccattg tggtgcccaa cttctttttg cctccccagc     7080

agttggaggc ttccctgcgg atgctttcac tctcagcaac tttgccacca gcagccacaa     7140

cagatcagga caagagcgaa gccaccaggg gagctctctc ccaaaggcct tgtcgcccca     7200

gacctaactc gctccccctc aacctgcctg aggaagaaac tctcaggatt gcacggatat     7260

tttcttctca gtactcccag aaagactga                                       7289


<210> 1081
<211> 461
<212> DNA
<213> Homo sapiens

<400> 1081
gcataccaac tcaccactcc tgacaccatg aactactacg gcaactacta tggaggcctg       60

ggctacggct acggaggctt cgatgacctg ggctatggct atggctgtgg atgtggcagc      120

ttccgcagac tgggctatgg cggtggctac ggaggctacg gatacggctc tggcttcgga      180

ggctatggat accgcagctg ccgtccatca tgctatggag gatatggatt ctctggattt      240

tattgaaatc cttccctgac aacctaacat gaggggacat aagaagatca cccaaacctg      300

actgcaataa caaacaaacg aggtcaccct ggatcaagcc aagatcaaga gcagttagca      360

tctaagaggt ttaagaatac ctatcattcc ataattcttt gctttatgtc tctggatgtg      420

tcttacttgt acctttataa ctgtggggtt tctctgttcc t                          461


<210> 1082
<211> 208
<212> DNA
<213> Homo sapiens

<400> 1082
atgtcctaca actgctgctg tggaaacttc tcctcccatt cctgtgaggg ctacctgtgc       60

tactcaggct actcccgtgg tggctcctcg taccccagca acctggtcta cagcactgaa      120

cctttgatct cccagcacct gccagctggg ttcctctctc tgcaagggct ttcaggagac      180

ttgctgggaa acccctagct gccagatg                                         208


<210> 1083
<211> 737
<212> DNA
<213> Homo sapiens

<400> 1083
ctgtcttgga aacctaccta gaacctccac cctctgacac catggttaac tcttgttgtg       60

gctctgtctg ctctgaccag ggctgtgatc aaggcctctg ccaagagacc tgctgccgcc      120

ccagctgctg ccagaccacc tgttgctgcc ccagctgtgt tgtatccagc tgctgccgcc      180

catcctgctc tcagactacc tgctgccaga ccacttgctg tcgccccagc tgctgccacc      240

cagtctgttg tcagaccacc tgccgcccca gctgtggtgt gtccagctgc tgccgtccac      300

tctgttgtca gaccacctgc cgccccagct gtggtgtgtc cagctgctgc cgtccactct      360

gctgtcagac cacctgctgc cgtgcaactt gctgccgccc cagctgctgt ggatcctctt      420

gttgaacctc atattggact atcaaccatg agccagtcac catcccatga tatgaaagtg      480

tcatttatat caacttgtcc atgtgttaaa tggccatcag ctttattatc ctgttattcc      540

actaagtaac tggtgaaagg gcatccatct acatttaata ccactcattt ttcccatgga      600

tctcttccca gcagcattca gacctcagat gcatgatgca gttagactaa gcctctaagt      660

ttctgactgt tatgcttgat ttgaccttca aaattacata ttaactgttc ttcaataaat      720

attatcttaa tatcagt                                                     737


<210> 1084
<211> 775
<212> DNA
<213> Homo sapiens

<400> 1084
gaactccggc tgcgttaccg acctgcgagc tgacgggccc ggaccatggg gtgctgcccg       60

ggggactgct tcacctgctg cacccaggag caaaactgct gtgaagagtg ctgctgtcag      120

ccgggctgct gtggctgctg cggctcctgc tgtggctgtg ggggctctgg ctgcgggggc      180

tctggctgcg ggggcagctg ctgcggatcg tcttgctgtg gatctggctg cggaggctgt      240

ggaggctgcg gaggctgcgg gggtggctgc tgtggatcca gttgctgtgg gtccagttgc      300

tgcggctccg ggtgctgtgg gcctgtgtgc tgccagccca cacctatatg cgacacaaaa      360

tgaagacctt tccctccacc actgatgcag tcccaccgaa agcctccatc tgctccaggg      420

ggacagcccc tcgtgtccag aaccttccat acccccaaga cagtgtcttg tctttctgtg      480

atttgtagag gagggcttgt tctccaacac cttctctggt atttcaaggc accgagaaca      540

agagccatac tctgatgaaa cattaaaact cggtcacaac taagtgatcc caagctcaag      600

ggtgaatccc caatacttta cttattcaca tgaagttcaa tgtcttgtac tataagacat      660

cctcttcttc aaggtgtctt tgggactgat cctccgccct ggctttctgc agctttgaga      720

tgcaaaaaag gtccatcttc tttgtgagcc tcttaataaa tttgagcatg ctggc           775


<210> 1085
<211> 4362
<212> DNA
<213> Homo sapiens

<400> 1085
agagcgaagc tgaggagtcc agcgctcgcc gacaggggcc tgggctgtcc cgagccggaa       60

tccagatctt acataagatg gaagtctctc acactagata ctgaacatta aatagaaaat      120

ctatttagta aaatctaagt tgccatggaa gaaataccag taaaagttgc tgtaagaatt      180

agacctctgc tttgcaaaga agctcttcat aatcatcaag tttgtgtgag agttattcca      240

aacagccagc aagttatcat tgggagagat agagtcttca cttttgattt tgtttttggc      300

aaaaattcca ctcaagatga agtttataac acatgtataa agcccctagt gttgtcactc      360

attgagggct ataatgcaac tgtttttgcc tatggacaaa ctggatctgg gaagacatac      420

accattggag ggggccatat tgcttcagtt gtggagggcc aaaagggtat cattcctcga      480

gctattcaag aaatatttca aagcatctct gaacatccta gcattgactt taatgtaaaa      540

gtatcttata tagaagtgta caaggaagac ctaagagatc ttctagaatt ggagacatcc      600

atgaaggatc ttcacatccg agaagatgaa aaaggaaaca cagtgattgt tggggccaag      660

gaatgccatg tggagagtgc aggtgaagtg atgagtcttt tggagatggg gaatgcagcc      720

agacatacag gtaccactca aatgaatgag cactccagca gatcacatgc aatttttaca      780

atcagcattt gtcaagttca taaaaatatg gaggcagctg aagatggatc atggtattcc      840

cctcggcata ttgtctcaaa gttccacttt gtggatttgg caggatcaga aagagtaacc      900

aaaacgggga atactggtga acggttcaaa gaatccattc aaatcaatag tggattgctg      960

gctttaggaa atgtaataag cgctcttggg gacccacgca ggaagagttc acatattcca     1020

tatagggatg ctaaaattac ccggcttctg aaagattctc tgggaggcag tgctaagact     1080

gtcatgatca catgtgtcag cccctcctcc tcgaattttg atgagtcctt aaattctctc     1140

aaatatgcca acagagcacg gaacattaga aacaaaccca ctgtaaactt cagccccgag     1200

tcagaccgta tagatgaaat ggaatttgag attaaattgc ttcgagaagc tttgcaaagc     1260

cagcaggctg gtgtcagcca aactacccag atcaatcgag aagggagtcc tgatacaaat     1320

aggattcatt ctcttgagga gcaagtagct cagcttcaag gagaatgtct gggttaccag     1380

tgttgtgtag aagaagcctt taccttcctg gttgacctaa aagatactgt cagactaaac     1440

gaaaagcagc aacacaaact gcaggagtgg tttaacatga tccaagaggt caggaaggct     1500

gtcctcacct catttcgagg aatcggaggc actgcaagtc tggaagaagg accacagcat     1560

gttacagttc tccagctgaa gagagagctt aagaaatgcc agtgtgtgct tgctgctgat     1620

gaagtagtat ttaatcagaa ggaactggag gtgaaggaac tgaagaatca agtgcagatg     1680

atggtacagg aaaacaaagg gcatgctgta tctttgaaag aagcgcaaaa agtgaataga     1740

ctgcagaatg aaaaaataat agaacaacaa cttcttgtgg atcaactgag tgaagaacta     1800

acaaaactta acctgtcagt gacttcttca gctaaagaaa attgtggaga tgggccagat     1860

gccaggatcc ctgaaaggag accatatact gtaccatttg atactcattt ggggcattat     1920

atttatatcc catcaagaca agattccagg aaggtccaca caagtccgcc tatgtactct     1980

ctggatcgaa tatttgctgg atttcgaaca cgaagtcaga tgctgttggg tcacatagaa     2040

gaacaagata aggtcctcca ctgccaattt tctgataaca gtgatgatga agaatcagaa     2100

ggccaagaga aatctggaac tagatgtaga agtcgttcat ggattcagaa gccagactct     2160

gtttgttccc ttgttgaatt gagtgatact caggatgaaa cacaaaagtc agatttggag     2220

aatgaagatt taaagattga ttgtctccag gagagtcaag aattgaattt gcaaaaatta     2280

aagaattcag aacgcatact tactgaagct aaacaaaaaa tgagagaact tacaattaac     2340

atcaagatga aggaagatct gattaaagaa ttaataaaaa caggtaatga tgccaagtct     2400

gtaagcaagc agtattcttt gaaagtaaca aagctagagc atgatgcaga acaggcaaaa     2460

gtcgaactga ttgaaacaca aaagcagcta caggagctgg aaaacaaaga tctttctgat     2520

gttgcaatga aggtaaaatt acagaaagag tttcgtaaaa agatggatgc tgcaaagctg     2580

agagttcagg tcttgcagaa gaagcaacaa gatagtaaga aactggcatc actgtcaatc     2640

caaaatgaga aacgtgctaa tgagctagag cagagtgtag atcacatgaa atatcaaaag     2700

atacagctac aaagaaaact acgagaagaa aatgaaaaaa ggaagcaact ggatgcagta     2760

attaagcggg accagcaaaa aatcaaagcc ttaaacacag atagtttgaa aatatcaact     2820

cgcctgaact tactggaaca agagttgtct gaaaagaatg tgcagctcca gaccagtaca     2880

gctgaggaga aaacaaagat ttcagaacaa gttgaagtcc tccagaaaga aaaggatcag     2940

ctccagaaac gcagacacaa tgtggatgaa aaacttaaaa atggtagagt gttatcacct     3000

gaagaagaac atgttctttt ccaacttgaa gaagggattg aagctttgga agctgcaatt     3060

gaatacagga atgaaagtat ccagaatcgc cagaagtcac ttagagcatc attccataac     3120

ctctctcgtg gtgaagcaaa tgtcttggaa aagctagctt gcctgagtcc tgttgagatt     3180

agaactattc ttttcagata tttcaataag gtggtgaatt tgcgagaagc tgaacggaaa     3240

caacagttat ataatgaaga aatgaaaatg aaagttctgg aacgggataa tatggttcgt     3300

gaattagaat ctgcactgga ccatctaaaa ttgcagtgtg accggagact gaccctccag     3360

caaaaggaac acgaacaaaa gatgcagttg ctattacatc atttcaaaga acaagatgga     3420

gaaggcatta tggaaacttt caaaacatat gaagataaaa tccagcagtt ggaaaaagat     3480

ctttatttct ataagaaaac cagccgggat cataagaaga aacttaagga actggtaggg     3540

gaagcaattc ggcggcaact agcaccatca gagtatcaag aggctggaga tggagtcctg     3600

aagccagaag gaggaggcat gctttcagaa gaattaaaat gggcatccag acctgaaagt     3660

atgaaattaa gtggaagaga aagagaaatg gacagttcag caagcagctt aagaacacag     3720

ccaaatcctc aaaagctctg ggaagatatc ccagaattac ctccaattca tagttcttta     3780

gcacccccca gtgggcatat gttaggtaat gagaataaaa cagaaacaga tgataatcag     3840

tttacaaaat ctcacagtcg actgtcatcc caaattcagg ttgtgggaaa tgtgggacga     3900

cttcatggtg tcacacctgt aaaactgtgt cgaaaagaat tacgtcaaat ttccgccttg     3960

gaactatcat tgcgacgttc cagtcttgga gttggcattg gatcaatggc tgctgattcc     4020

atcgaagtat ctaggaaacc aagggactta aaaacttaga cattgaataa tagaactttt     4080

agtagatatg taaaaagatt cctttttcta acctgttaaa aactaaagct caagttcact     4140

acctctttcc tcagaataaa ggaagaaggg gaggaaggaa tccctaattc ttttatatgc     4200

tatagatgtg tacatcttct atatatattt ggggagtttt agtttatatt cccatagtaa     4260

tcaaacatgt tttccaatac ttgataacat ttaaatattt ataaatacgc ttaaatgttt     4320

ttccaggcat atttgaagat taaaactagt aatagactaa aa                        4362


<210> 1086
<211> 2064
<212> DNA
<213> Homo sapiens

<400> 1086
gtcccggctc cagaacgccg cggcactggg gcgggagggg cccgccacgt ccgccatctt       60

gaaacaaccg ccactcgggg cgtcgcgcct gggccgccac gcctcggcct gcaggctcgg      120

tccccattgg ccgcaccacg cagaggcccg cccccgcctg cgcggccggc ccctgcgggg      180

cgagagggtg ggggcgaagg ggaagctacg tcccggaggt gcggtgtggg gcaccgggcg      240

gggccgcggg aaccggcgcc ccacggagct gctgctgtca gaccaacccc gggcccccat      300

catcactgcg ccgcgctttc aggcgccgag aactaccgtt cccggcatgc catgaaattg      360

gcctcggcgc tgaggcgggg tccggccctc cacccgctcc cgccgcgcgc gaatcgcggt      420

cgcgagccat ggaggaggag gcatcgtccc cggggctggg ctgcagcaag ccgcacctgg      480

agaagctgac cctgggcatc acgcgcatcc tagaatcttc cccaggtgtg actgaggtga      540

ccatcataga aaagcctcct gctgaacgtc atatgatttc ttcctgggaa caaaagaata      600

actgtgtgat gcctgaagat gtgaagaact tttacctgat gaccaatggc ttccacatga      660

catggagtgt gaagctggat gagcacatca ttccactggg aagcatggca attaacagca      720

tctcaaaact gactcagctc acccagtctt ccatgtattc acttcctaat gcacccactc      780

tggcagacct ggaggacgat acacatgaag ccagtgatga tcagccagag aagcctcact      840

ttgactctcg cagtgtgata tttgagctgg attcatgcaa tggcagtggg aaagtttgcc      900

ttgtctacaa aagtgggaaa ccagcattag cagaagacac tgagatctgg ttcctggaca      960

gagcgttata ctggcatttt ctcacagaca cctttactgc ctattaccgc ctgctcatca     1020

cccacctggg cctgccccag tggcaatatg ccttcaccag ctatggcatt agcccacagg     1080

ccaagcaatg gttcagcatg tataaaccta tcacctacaa cacaaacctg ctcacagaag     1140

agaccgactc ctttgtgaat aagctagatc ccagcaaagt gtttaagagc aagaacaaga     1200

tcgtaatccc aaaaaagaaa gggcctgtgc agcctgcagg tggccagaaa gggccctcag     1260

gaccctccgg tccctccact tcctccactt ctaaatcctc ctctggctct ggaaacccca     1320

cccggaagtg agcacccctc cctccaactc cctaccagct ccagagtggt ggtttccatg     1380

cacagatggc cctaggggtg acctccagtt ttgcgtgtgg accgtaggcc tctttctagt     1440

tgaatgacca aaattgtaag gcttttagtc ccaccgacat tagccaggct cgtagtgagg     1500

cctccagagc aggttgtgct gtcccctgcc tctggaagca atggggaatt tggaatcttg     1560

tgtaagtgcc caaataagtc tgagtgcttt cctcttcttc aacactcaac cctcaatccc     1620

ttagcactga ttgattagag aggtccccca aagaaaccac tggttttgac ccatgaagca     1680

ttagaactgc attgttcatt caggagccac tagtcacata tgactattta aatttaaagt     1740

aaattgtatg aaaaattcat ttcttcaatt gcattagcca cattttgagt attcatgtgg     1800

ctggtagatt ctgtattagc acaaagatat ggaacatttc catcaccaca gaaagttctg     1860

ttggacagca ctgcattaga atattttcat actgctcttc ctcaattaat ttttgttgtt     1920

aatgttgatg tcttcattgg atgggtcata atgttccatg aaacctctca agtacacaat     1980

tgtatgttct ttgtatccct taccacaaat atctcgctct gctcatttct tttgcagctt     2040

cctataaagt ttgtcttcct catc                                            2064


<210> 1087
<211> 492
<212> DNA
<213> Homo sapiens

<400> 1087
gcaaataaag aacgcaggag ccttgtctcc tactgggctg tcagtgagga aaaggaggaa       60

agacaggtta gctggggatg atgacggatc tgaagcaaag ccattcagtg aggctgaatg      120

atggaccctt catgccagtg ctgggatttg gcacttatgc tcctgatcat actcccaaaa      180

gccaggctgc cgaggccacc aaagtggcta ttgacgtagg cttccgccat attgattcag      240

catacttata ccaaaatgag gaggaggttg gacaggccat ttgggagaag atcgctgatg      300

gtaccgtcaa gagagaggaa atattctaca ccatcaagct ttgggctact ttctttcggg      360

cagaattggt tcacccggcc ctagaaaggt cactgaagaa acttggaccg gactatgtag      420

atctcttcat tattcatgta ccatttgcta tgaagggttc ttcctgagag aggcagattt      480

gagtgaggtg ca                                                          492


<210> 1088
<211> 1438
<212> DNA
<213> Homo sapiens

<400> 1088
agtgcgcgtg cgcagcggtt gcctgggcga ccggggaagc gttgggctgt aaagactagg       60

gcgccagcgg ctggcgaaga aggaaagagg gtactctctg gctgggctgg ggccgtagcg      120

acgtccgccg cgaacctggg ccccccaaag ctgcggggcg ttcggtgtcg ccgaagtaaa      180

catgcaccct gagccctcgg agcctgcgac aggtggtgca gcagagctgg attgcgcgca      240

ggagcccggc gtggaggagt ctgcgggtga ccacgggagc gcaggccgag ggggctgcaa      300

ggaagaaatt aatgatccta aggaaatatg tgtgggttct tctgacacat cctaccacag      360

ccagcagaaa cagagtggtg ataatgggtc aggtggtcac ttcgcacacc caagagaaga      420

cagggaagat cggggcccca gaatgactaa aagttccctg caaaaactct gcaagcagca      480

caagctttat attaccccag cattgaatga tacgctgtat ttacacttta aaggttttga      540

tcgcattgag aacctggaag agtacacagg gctgcgctgt ctctggctgc agagcaatgg      600

aatacagaaa atcgaaaacc tggaggccca aactgagttg cgttgcctct tcttgcaaat      660

gaacttgctc cgtaaaattg agaacctgga acctctgcag aaactggatg ctcttaacct      720

cagcaacaat tacatcaaga ccattgaaaa cctctcctgc ctcccagtcc tgaacacatt      780

gcagatggcc cacaatcacc tggagaccgt ggaggacatt cagcatctac aagagtgttt      840

gaggctttgt gtccttgacc tttcgcacaa caagctgagt gacccggaga tcctgagcat      900

tctggaaagc atgcccgatt tgcgtgtact gaatttgatg ggaaacccgg ttatcagaca      960

gattcctaat tacagaagga cagtcactgt acgactaaag cacttaacat acctggatga     1020

tagaccagtg tttccaaagg acagagcttg tgcggaggcc tgggctaggg gagggtacgc     1080

agctgaaaag gaggagagac agcagtggga gagcagggag cggaagaaga tcacagacag     1140

cattgaagcc ttggccatga tcaagcagcg ggcagaggag aggaaaagac agagagagag     1200

tcaagagaga ggggagatga catcttcaga tgatggtgag aatgtgcccg ccagtgcgga     1260

aggcaaggag gagcctcccg gggacagaga aacaaggcag aagatggagc tatttgttaa     1320

ggaaagcttt gaggccaagg acgagctctg cccggaaaag ccaagtggag aggagccgcc     1380

tgtggaggct aaaagagagg atggagaccc tgctactgtc accgcctgtg aaggttaa       1438


<210> 1089
<211> 3004
<212> DNA
<213> Homo sapiens

<400> 1089
attgctttcc aggggtcact ctggcttcga ctccgtcgct ctcaattcgt caccaggagg       60

aagacggagc tggctgccca gcccaaaggc ccatgagggg atgcagttat gggctctgtc      120

gccgtggaac ttgtttgctt cattcttatg tacctacctt tgcaccttgt aatcatcctt      180

tatgcctcag attgttattt tgtgtcagta agtaatccat aaagtgccaa catgggaaag      240

aaacggacaa agggaaaaac tgttccaatc gatgattcct ctgaaacttt agaacctgtg      300

tgcagacaca ttagaaaagg attggaacaa ggtaatttga aaaaggcttt agtgaatgtg      360

gaatggaata tctgccaaga ctgtaagact gacaataaag tgaaagataa agctgaagaa      420

gaaacagaag aaaagccttc agtttggctg tgtcttaaat gtggccatca gggctgtggc      480

agaaattctc aggagcagca tgccttgaag cactatctga cgccaagatc tgaacctcac      540

tgtctggttc ttagtttgga caactggagt gtatggtgtt acgtatgtga taatgaggtc      600

cagtattgta gttcaaacca gttgggtcaa gtggttgatt atgtcagaaa acaagccagc      660

attacaactc caaagccagc agagaaagat aatggaaata ttgaacttga aaataaaaaa      720

ttagaaaaag agagtaagaa tgaacaagag agagaaaaga aggaaaacat ggctaaagag      780

aatcctccca tgaattctcc ttgccaaata accgtgaaag gactcagtaa tttgggaaac      840

acatgtttct tcaatgcagt tatgcagaac ttgtcacaaa caccagtgct tagagaacta      900

ctaaaagaag tgaaaatgtc tggaacaatt gtaaaaattg aaccacctga tttggcatta      960

acagaaccat tagaaataaa ccttgagcct ccaggccctc ttactttagc catgagccag     1020

tttcttaatg agatgcaaga gaccaaaaag ggggttgtga caccgaaaga actcttttct     1080

caggtctgta aaaaagcagt gcggtttaaa ggctatcagc agcaagacag ccaggagctg     1140

cttcgctact tattggatgg gatgagagca gaagaacacc aaagagtgag taaaggaata     1200

cttaaagcat ttggtaattc tactgaaaag ttggatgaag aactaaaaaa taaagttaaa     1260

gattatgaga agaaaaaatc aatgccaagt tttgttgacc gcatctttgg tggtgaacta     1320

actagtatga tcatgtgtga tcaatgcaga actgtctcct tggttcatga atctttcctt     1380

gatttgtccc tcccagtttt agatgatcag agtggtaaga aaagtgtaaa tgataaaaat     1440

ctgaaaaaga cagtggagga tgaagatcaa gatagtgagg aagaaaaaga taacgacagt     1500

tacataaaag agagaagtga tattccttct ggaacaagta agcacttaca gaaaaaagca     1560

aagaaacaag ccaaaaagca agccaagaac caacgaagac aacaaaaaat tcaaggaaaa     1620

gttcttcatt taaatgatat ttgtactatt gaccatcctg aagacagtga atatgaagct     1680

gaaatgtcac ttcaaggaga agtaaatatt aaatccaacc atatttcaca agagggtgtt     1740

atgcataaag aatattgtgt caaccagaaa gatttgaatg gccaagcaaa aatgatcgaa     1800

agtgtaactg acaatcaaaa atccacagag gaagtagata tgaaaaatat caacatggat     1860

aatgatctgg aggttttaac atcttctccc actaggaatt taaatggtgc ctacctaacg     1920

gaagggagca atggagaagt ggacatttcc aatggtttca aaaacctaaa tttgaatgct     1980

gctcttcatc ctgatgaaat aaatatagag attctgaatg atagtcatac tcctggaaca     2040

aaggtgtatg aggttgtaaa tgaagatcca gaaactgctt tctgtactct tgcaaacagg     2100

gaagttttca atactgatga gtgttcaatc caacattgtt tatatcagtt cacccgtaat     2160

gagaaacttc gagatgcgaa taaactgctt tgtgaagtat gcacacggag acagtgtaat     2220

ggaccaaagg caaatataaa aggtgaaagg aagcatgttt acaccaatgc caaaaagcag     2280

atgctaattt ctcttgctcc tcctgttctt actcttcatt taaagagatt tcagcaggct     2340

ggttttaacc tacgcaaagt taacaaacac ataaagtttc cggaaatctt agatttggct     2400

cctttttgca cccttaaatg taagaatgtt gcagaagaaa atacaagggt actctattcc     2460

ttatatggag ttgttgaaca cagtggtact atgaggtcgg ggcattacac tgcctatgcc     2520

aaggcaagaa ccgcaaatag tcatctctct aatcttgttc ttcacggtga tattccacaa     2580

gattttgaaa tggaatcaaa agggcagtgg tttcacatca gcgacacaca tgtgcaagct     2640

gtgcctacaa ctaaagtact aaactcacaa gcgtacctcc tattttatga gagaatactg     2700

taataatatc aaaagcactt tttctggaaa cacatttatg gcttttataa tggctgaaat     2760

aacgataaaa aaagactaat taaaatcatg ttcacttaac attaaataca tgccagaaga     2820

aatcatgttt atttaaatat tgaagggaaa aatacctaaa aatgtacaaa ggttttatat     2880

tgtcatagtg gtttttattc ctgctttgtt tctggaaagg aaatcctgaa ttacttaagt     2940

actttgtgtt taatatatct gggtgatgga tcacaacaca tcaataaact gacttaccct     3000

aaaa                                                                  3004


<210> 1090
<211> 7546
<212> DNA
<213> Homo sapiens

<400> 1090
cgggcgccgg ggagagcggg cggccgggcg gcaggcgggc gagcagcgat cgggcggccg       60

agcgagcgag caacgccggc gcagcgcggt gaccccagcc ccagccggcg cggagcagga      120

gccggagccg agcggatctc ggcgccctcg ctgcgctcct cccggcccga gcctgcccta      180

cccggcggtg gcggcggcgc gtcctccagc ggcggcagcg gcgctcgcag cgcccggact      240

cacggcagct gtgttctgat ttcgtactac tgctggggct gccacctcct cctccagacg      300

ctctcagcag acttgagtcc tggtccttct gcagaggcct gagcaggagg aagaggagga      360

ggcccgttgg cgtcggacca atgctgcaag gggtgtgagg agaggagccg ctgtttttca      420

ctgagctgcc ataccccgaa agcaggatgg agctggagtg aggtggaggg gccgcaagct      480

gctgaccggc gtgtggaaca ctggtggttt gcagatcact gaggctggac aacgttcatg      540

gctctcgggt agaacctagt gaaacggcca gaatgaattc tatggacagg cacatccagc      600

agaccaatga ccgactgcag tgcatcaagc agcacttaca gaatcctgcc aacttccaca      660

atgccgccac ggagctgctg gactggtgcg gagacccacg ggccttccag cggcccttcg      720

agcagagcct gatgggctgt ttgacggtgg tcagtcgggt ggcagcccag caaggctttg      780

acctggacct cggctacaga ctgctggctg tgtgtgctgc aaaccgagac aagttcaccc      840

cgaagtctgc cgccttgttg tcctcctggt gcgaagagct cggccgcctg ctgctgctcc      900

gacatcagaa gagccgccag agcgatcccc ctgggaaact ccccatgcag ccccctctca      960

gctccatgag ctccatgaaa cccactctgt cgcacagtga tgggtcgttc ccctatgact     1020

ctgtcccttg gcagcagaac accaaccagc ctcccggctc cctttccgtg gtcaccacgg     1080

tttggggagt aaccaacaca tcccagagcc aggtccttgg gaaccctatg gccaatgcca     1140

acaaccccat gaatccaggc ggcaacccca tggcgtcggg catgaccacc agcaacccag     1200

gcctcaactc cccacagttt gcggggcagc agcagcagtt ctcagccaag gctggccccg     1260

ctcagcccta catccagcag agcatgtatg gccggcccaa ctaccccggc agcgggggct     1320

ttggggccag ttaccctggg ggtcctaacg cccccgcagg catgggcatc cctccgcaca     1380

ccaggccgcc tgctgacttc actcagcccg cggcagccgc tgcagcagcg gcagtggcag     1440

cagcagcagc cacagctaca gccacagcca cggccactgt ggcagccctg caggagacac     1500

agaacaagga tataaaccag tatggaccga tgggtcccac ccaggcgtat aacagccaat     1560

tcatgaacca gcccgggccg cgggggcctg cctccatggg gggcagcatg aaccccgcga     1620

gcatggcggc tggcatgacg ccctcgggga tgagcggccc tcccatgggc atgaaccagc     1680

cccggccgcc cggcatcagc ccctttggca cacacgggca gcggatgccc cagcagacct     1740

acccgggccc ccggccccag tcccttccta ttcagaacat aaagaggcca taccctggag     1800

agcccaacta tggaaaccag caatatggac caaacagcca gttccccacc cagccaggcc     1860

agtacccagc ccccaacccc ccgaggccac tcacctcccc caactaccca ggacagagga     1920

tgcccagcca gccgagctcc gggcagtacc cgccccccac ggtcaacatg gggcagtatt     1980

acaagccaga acagtttaat ggacaaaata acacgttctc gggaagcagc tacagtaact     2040

acagccaagg gaatgtcaac aggcctccca ggccggttcc tgtggcaaat tacccccact     2100

cacctgttcc agggaacccc acacccccca tgacccctgg gagcagcatc cctccatacc     2160

tgtcccccag ccaagacgtc aaaccaccct tcccgcctga catcaagcca aatatgagcg     2220

ctctgccacc acccccagcc aaccacaatg acgagctgcg gctcacattc cctgtgcggg     2280

atggcgtggt gctggagccc ttccgcctgg agcacaacct ggcggtcagc aaccatgtgt     2340

tccacctgcg gcccacggtc caccagacgc tgatgtggag gtctgacctg gagctgcagt     2400

tcaagtgcta ccaccacgag gaccggcaga tgaacaccaa ctggcccgcc tcggtgcagg     2460

tcagcgtgaa cgccacgccc ctcaccattg agcgcggcga caacaagacc tcccacaagc     2520

ccctgcacct gaagcacgtg tgccagccgg gccgcaacac catccagatc accgtcacgg     2580

cctgctgctg ctcccacctc ttcgtgctgc agctggtaca ccggccctcc gtccgctctg     2640

tgctgcaagg actcctcaag aagcgcctcc tgcccgcaga gcactgtatc acgaaaatca     2700

agcggaattt cagcagcgtg gctgcctcct cgggcaacac gaccctcaac ggggaggatg     2760

gggtggagca gacggccatc aaggtgtctc tgaagtgccc catcacattc cggcgcatcc     2820

agctgcctgc tcgaggacac gattgcaagc atgtgcagtg ctttgatctg gagtcatacc     2880

tgcagctgaa ttgcgagaga gggacctgga ggtgtcctgt gtgcaataaa accgctctgc     2940

tggagggcct ggaggtggat cagtacatgt ggggaatcct gaatgccatc caacactccg     3000

agtttgaaga ggtcaccatc gatcccacgt gcagctggcg gccggtgccc atcaagtcgg     3060

acttacacat caaggacgac cctgatggca tcccctccaa gcggttcaag accatgagtc     3120

ccagccagat gatcatgccc aatgtcatgg agatgatcgc agccctgggc cccggcccgt     3180

ccccctatcc cctcccgcct cccccagggg gcaccaactc caacgactac agcagccaag     3240

gcaacaacta ccaaggccat ggcaactttg acttccccca cgggaaccct ggagggacat     3300

ccatgaatga cttcatgcac gggccccccc agctctccca ccccccggac atgcccaaca     3360

acatggccgc cctcgagaaa cccctcagcc accccatgca ggaaactatg ccacacgctg     3420

gcagctctga ccagccccac ccctccatac aacaaggttt gcacgtacca caccccagca     3480

gccagtcagg gcctccatta catcacagtg gggctcctcc tcctcctcct tcccagcctc     3540

cccggcagcc gccacaggcc gctcccagca gccatccaca cagcgacctg acctttaacc     3600

cctcctcagc cttagagggt caggccggag cgcagggagc gtccgacatg ccggagcctt     3660

cgctggatct ccttcccgaa ctcacaaatc ctgacgagct cctgtcttat ctggaccccc     3720

ccgacctgcc gagcaatagt aacgatgacc tcctgtctct atttgagaac aactgagggc     3780

cacccggtcg gggccatccc tccacactct gcatcctacc ccacctaccc aacacacttt     3840

tccacctggg agcctgtgcc ctcagaccgc cccgcaccag agccacgggc tgtggggcgg     3900

ggagccctcc cccgctgcag ccctctcaga acagaggggt agggagggtg caccagtgca     3960

ccaggaaggc tgtgtgggtc tggagcccac gtcccacctc cacacccttg gcttgggccc     4020

atgcccagcg caggcctgaa gaccaccctc ccgagaggaa ccagcccggt aagagggcac     4080

acgctgatgc ggcttcccgg tccctccgcg tgtgccgatt ccagatgacc ttccagtgtc     4140

cccaaggttc ttccatcttc tagactgtaa ccctgcctcc ctgcttcctg gtccagagcc     4200

tccctccagt gactgtggag cctgagaagg cccccgggcc ccagcatggg ccccgagcct     4260

tggaggagca ctggcagttg gtggcagtga gaccagccca cccaccacca cccaccacag     4320

aaaagcacaa acctctggga aagacaacgt ctctcggggg ccaggggtca tcggtttgac     4380

ccctgaccta taagccaaga taccccataa acacactcag aaagcagaga aaaaggacaa     4440

gagtctgtgt ttgagagggg gtctgccatt cctgcttggg gactggtggg gaagagggcc     4500

aggacatctt ctgagccagg acgtccctga ggctccacct ccaagctcag acagggccca     4560

ggcttgggga acagagagag caggtgtaca cccaaccaaa gtgattgtgc ccttggttgg     4620

ggggcgcggg catataacct gtcagaagca aacaggagcg gcaacttcta actttgctcc     4680

aagccactct ctttttaaac agcaacaatt taaagctatg aagtcacctg gagaaaagga     4740

acgttgctct tggacagcaa gcaaaccatt tctctccgtc tgttctgttt ttctcctagt     4800

ccctctcctg ccacctctcc aagacttccg tgggacaccc acttccctct gtcctagttc     4860

tctttgtcca atcagatggc aagggcagtg cgtggaaagg ccggggaggt gcagaaacca     4920

gagcccaggg caatggtgtc tgtccagccc ctccctctgt ccctgtgctc caagctgccc     4980

ccggctgcag cccaggccat ggacatgtgc accagtatgt acctgcaggc atggggggga     5040

ggggggcgtg tttctgggcc tgccccagac actgcccttg gctgccagcc taccctgcct     5100

gcactcctcc accatcacaa tctcacccaa actcctgctc actcaagcaa aagcagcctc     5160

tggccttccc tccaccgctt tgctccatct ggcttaccac tctccagggc ctcctgggga     5220

gcctgtcctg tgttcacttt gtttcaggct ggtctgtgcc ccgtgagcca catggcctag     5280

ggtgatgcca ggttgtcccg tcactggggt cccatctgta aattctttgc gcccttcccg     5340

gctgctgcct ggggcccttt cctgctctcc cgtccgctgt gggtggtccc cagctctcct     5400

ctgtgggttt taccggaaag gtggccccag ctgttgactt ccagtcactg tcccagacgg     5460

cacaaggttt tctgtaggaa agctgccatt gccccggccc cttttcttcc tttgtcccgt     5520

tgtcgaggtt ttttcaaata gcgtgttgtt cagtatgcaa atcaattatt ttaagaatcg     5580

cttttgtaaa tatctttgtg aatattttag tatcgtcttt gataatattc aacattttca     5640

tgacctggtt atagcctttg ctggtgtttt taaaatacct ggactcaatg acaaagaccg     5700

agtcttcttt ttttttaaac aaaaacaaaa aaagcaacca gggctatttg tacagttgaa     5760

ggggtgaaca gaatgggcgg ctgtgctggg agttggaaga ccgggcagcc cgctatttag     5820

agccatccct cagtcagctg gcagggacaa gccaacgcca ggtagcatgt ggccaccctt     5880

gcccagtgtc tgtggcctgg caagtggcca cgccctgtgt cagaccatct gggaattaag     5940

ctccagacag acttacagat gccttcctta ggagttcttg cttcttgcgt tgatactttg     6000

ccccagaaag gcctgggatt cattctggtt cttatcaggg tgtgtccaca ctctgctcac     6060

aggtggatcc acggctttcc agtgcggaga gtcgagatgc tccctgcagc ccaggccccg     6120

ggcacctcct gcaaccatct ctgggctcag cacctgaggc gggtttcctg ggtcccctct     6180

ccagcaagcc tccaccagca agctcggccc agagcttccc ttccggctgg ctctgaaccg     6240

tgcgtggtgc ctacagcctg cagtctggag acaagctctt ccggagtgct ctgggagcca     6300

ggccagggtg tgagggaggt gcagaggcat ccggggcggg agcaagcccc aggttgtgac     6360

aggtgcaggt agacaacgcc cataaacaga gatggtcctg aactctggag agatccttcc     6420

ctgatccttt cggacgacta cttggagcca taagtaacct cagcaaaaac gaggcctctg     6480

caagccactt ttccatgcca agcatccacc cggcccacag gcatgtttct gccgccactc     6540

cgcaagatgg acagggagcc agcaggcagg cgggaagggc caagtacagg caatcacccc     6600

catcttcttg gtttgaagct ttatccatgt atcatgttcc gtgtagccat tttatttttt     6660

aagaaactgc taatactttc tccctaatgg aagccctgat cccccagaga gctacaggtc     6720

tgctcccgac gggcctcggg cctgacccgt ccacacaggg ccgtgtcaac agcagcgact     6780

caagggacgt gtgtacatat gtaaatgaga aatagagacg tgtcaacaga tgcattcatt     6840

tctcttggaa tgtgtattgt ttttattttg cgaaacaaaa caaaacaaaa aaaaaagctt     6900

ggaactccat cacgtggaaa aactagatcc tgttggttat agcatttgtg agttctccac     6960

gtctgtctct ctcgctcatg taatatactc tgaccctgag tggaaagggg tttttgttct     7020

gtttttattt tacctacatg tactatttag cttcagtgta ctagtcctgc cacctgtgta     7080

tttttagggt gctatggaaa taatgaaaag aaacggggat ttcagaagaa aattgtaacc     7140

aaattcatac tttgtataat ttttgatatc atgatcacag gtgattcaca cgtacacaca     7200

taaacacacc caccagtgca gcctgaagta actcccacag aaaccatcat cgtctttgta     7260

catcgtatgt acaatgcaat catttcatac tttaaactgg tcaaaaaact aattgtgatt     7320

tctagtcttg caaagctgta tgtagttaga tgatgtgaca acctctaata tttatctaat     7380

aaatatgtat tcagatgaaa cctgtatatt aggtgttcat gtggttattt tgtatttaaa     7440

gatcaaatta tttgactatt gctagacatt tctatactct gttgtaacac tgaggtatct     7500

catttgccca tgttaatttt tttctaaata aattgacaaa aacaaa                    7546


<210> 1091
<211> 2377
<212> DNA
<213> Homo sapiens

<400> 1091
gacacccagg cagtccctga cgtgtcgggg aggagccggg cgcggaggta cgctgagtgg       60

agctcggggc tgcgtagggg agctgagccg agcggctggg cgggcctggc cgggccggcg      120

gaggggagac gtcggttgag cggcggcgaa catgcgcttt tgacacattg gaggctttct      180

tgatcatgga tggtgaagat ataccagatt tttcaagttt aaaggaggaa actgcttatt      240

ggaaggaact ttccttgaag tataagcaaa gcttccagga agctcgggat gagctagttg      300

aattccagga aggaagcaga gaattagaag cagagttgga ggcacaatta gtacaggctg      360

aacaaagaaa tagagacttg caggctgata accaaagact gaaatatgaa gtggaggcat      420

taaaggagaa gctagagcat caatatgcac agagctataa gcaggtctca gtgttagaag      480

atgatttaag tcagactcgg gccattaagg agcagttgca taagtatgtg agagagctgg      540

agcaggccaa cgacgacctg gagcgagcca aaagggcaac aatagtttca ctggaagact      600

ttgaacaaag gctaaaccag gccattgaac gaaatgcatt tttagaaagt gaacttgatg      660

aaaaggaatc tttgttggtc tctgtacaga ggttaaagga tgaagcaaga gatttaaggc      720

aagaactagc agttcgggaa agacaacagg aagtaactag aaagtcggct cctagctctc      780

caactctaga ctgtgaaaag atggactccg ccgtccaagc atcactttct ttgccagcta      840

cccctgttgg caaaggaacg gagaacactt ttccttcacc gaaagctata ccaaatggtt      900

ttggtaccag tccactaact ccctctgcta ggatatcagc actaaacatc gtgggggatc      960

tcttacggaa agtaggggct ttagaatcca aattagcagc ttgcaggaat tttgcaaagg     1020

accaagcatc acgaaaatcc tatatttcag ggaatgttaa ctgtggggtg ctgaatggca     1080

atggcacaaa gttctctcga tcagggcata catctttctt cgacaaaggg gcagtaaacg     1140

gctttgaccc cgctcctcct cctcctggtc tgggctcctc gcgtccatcg tcagcgccgg     1200

gtatgctgcc tctcagtgtg tgagtgccta gcctccaggt gggggctcct gccctcctcc     1260

aacaacccag gacacccacg cctcacccct cggtgcctgg gcccagcccc gtgcccctcc     1320

gtctgcctcc gcacggctgg cagagggcag gctgcatgca gtggcggcta ctgggccctg     1380

cccagccccg gaactctgcg cgatatcaat actggctatt ttctcttctc gccgtagtgc     1440

cgttggtttc acatgattgc acttttgtgg gtcgcaaggt gatacatacg tgtattactt     1500

ggtcactgga tgcagaagta cccattcatc acacctgccc catagccccc actctgctgt     1560

actgatagga tttagttgtg ttttaggaca ttgcaaatct tctagaagtt ctcccccaaa     1620

tcaggtcaat gtgtgccctc ctgagctccc acccaggcat ctccagtgct catgatcatg     1680

tgtcccccaa ctccacccct cacagtttgg gcctgtttct ggcaaagagt caggaaggtt     1740

actgaattag ggaacatttt ctgcaccttc tgattttact taagcagcta ccattccatg     1800

gacttgcctc ccagagcagc acaatgcccg tctgagcccc acgtggcagg agcctctggg     1860

acggggcaca cacaggccca gcctctgtgc tgtctcctcc tccgtgcgcc tcagactcgg     1920

ggtgagggag gcgggcagcc tctcgccagc cttcccgtcc ttcagttcaa cgacatcttt     1980

ggagtgtttt tgttttctct tccaagggcc gtcccgttgt gttaggaagg gtgagtggct     2040

ggttccaggg tgggccggtg ccagctccgg ggtggactga acagcggcgg ctgtccctgt     2100

gcatcctttg attactctca tgctgcattt actgtttaca tttgttttat tgtacatagg     2160

tttgtaaaca ttattgcctg agatatttgt atataacttg ggctttgtag cttttattta     2220

ttcagaacgc atacggcatg ttaatgactc tgatggtgtc ctcctctggg cagctgtata     2280

ggatcatcat gtggttacaa aaaatacttc cctcaaaaaa attcttttaa tgtggaaaca     2340

ataaatttca cagaaaaaaa ggattgacgt tgcttta                              2377


<210> 1092
<211> 3284
<212> DNA
<213> Homo sapiens

<400> 1092
cattcggggc tggaactcga acgctgacgt tggctcctga gccgggcgct gcctcgcgcc       60

tgattggcgg gtcctcgggg ccgccctccc cagcgcacca cccctgggtt ccctcccggg      120

tccgcagtgg aaacactgcc ctctcccttc ttgaccccta gcccttcctt ccctccctcc      180

ttccctcctg tcgccgtctc ttctggcgcc gctgctcccg gaggagctcc cggcacggcg      240

atgggttctc gggcctccac gttactgcgg gacgaagagc tcgaggagat caagaaggag      300

accggctttt cccacagtca aatcactcgc ctctacagcc ggttcaccag cctggacaaa      360

ggagagaatg ggactctcag ccgggaagat ttccagagga ttccagaact tgccatcaac      420

ccactggggg accggatcat caatgccttc tttccagagg gagaggacca ggtaaacttc      480

cgtggattca tgcgaacttt ggctcatttc cgccccattg aggataatga aaagagcaaa      540

gatgtgaatg gacccgaacc actcaacagc cgaagcaaca aactgcactt tgcttttcga      600

ctatatgatt tggataaaga tgaaaagatc tcccgtgatg agctgttaca ggtgctacgc      660

atgatggtcg gagtaaatat ctcagatgag cagctgggca gcatcgcaga caggaccatt      720

caggaggctg atcaggatgg ggacagtgcc atatctttca cagaatttgt taaggttttg      780

gagaaggtgg atgtagaaca gaaaatgagc atccgatttc ttcactaaag gagaccaaac      840

tgttccttgc ggtctagtat ttaagaactg gaacttgaaa gtcctccttc taccaactcc      900

acctccaccc cctcattccc cttctcccaa agtactactg ctgttgcatg acaaccccaa      960

atatgttctg tcaacacaaa cctgcctttg gtgtataaac agggcattac agaatggtac     1020

accctatata tttctgttca gtatccattc actagttctt catttataaa tatcatcttc     1080

cccattctgc tgctgaatgc cacacatcca tccagtctga gaaagtgaga gaggcaatca     1140

tgccaagaac aagccagcaa agctctttca ccagatgtag actgtagccc tgctgccttc     1200

cctccagcga gtctgccagc atgcttcttc atccttttta tatgttcttt gcttcctact     1260

tccctgtctt ccaacatact gttcacttac tctggcagtc tttctgcttt tcattaagcc     1320

tcaaaatctc ctctgttcta cttggcacca caagctatgt cctatatatg tatttctgac     1380

ttggcaggat agttcagggg tctggcagtt tttatttacc ttcattatta aatgggcctc     1440

tgggatgttg cctcttcagg agctttttgg taatcaatac ttctctcaga agtatgagac     1500

catcctctgc actctgctct gtcatcaaag gctgctgggt ggagataccc tttttgaaag     1560

gtggccttgg tgagaggtat ggagccaagt cttctaggtt gcttgcccac atcactctat     1620

ctctggcctc tgattctcaa ctttgtacct gtgtggctcc tcttgttagt gcaatgttga     1680

ctgttgaaaa agcagcagta tgcttacagg tttgcttagt ttggggacac cgttaccacc     1740

agaatggctg ctctgacaat atgcctaggg actttctcat ggcttttatt taataaggag     1800

gctgggcacc ctataaagcc tcatgcattc acacctttgc agcatggttt atgcctcagt     1860

gttatgtgca ctggaatgtt ttccacttca catttccaag tagaaatatt agtgttacgg     1920

aagtgcctaa tatcccagtc caaatttttt tttttttttt tttttttttt tgagacagag     1980

tcttgctctg tcacccaggc tggagtgcag tggtgcgatc gctcactgca acctcagcct     2040

cctggattta agtgattctc ctgcctcagc ctcccaagta gctgggatta caggtgtgca     2100

ccaccatgcc cggctaattt tttgtatttt tagtggagac agggtttcac catgttggcc     2160

aggctggtct cgaactcctg acctcgtgat ccgcctgcct cagcctccca aagtgctggg     2220

attacaggtg tgagccacca cgcctggccc cagtccaaaa tatttaaaga ttgtttcctt     2280

agtgtcttga agttttgcac aaaattcttt tttttgagat ggagtctcac tctgtcaccc     2340

aggctggagt gcagtggcgt gatcttggct cactgcaacc tctgcctcct gggttcaagc     2400

aattctccca cctcagcctc ccaagtagct gggattacag acgtgtgcca ccatacctgg     2460

gtaatttttg catttttagt ggagagggag tttcaccatg ttggccaggt tggtcttgaa     2520

ctcctgacct caggtgatcc tcctgcctcg gcctcccaaa gtgctgggat tacaggcatg     2580

agccaccgtg ctcagccgca aaattcttta tgaattttac acttggcaaa tgttaatgac     2640

ggaagccata gtctgctcct aatacatgtc caaagcattg actgttgtgt cattagctgc     2700

ctggttacat tagctccctg gcttcttgtt tagaccactg ctaatccctt aaaaacaaga     2760

ggtctggcac tagtagcaca acctaaggtg gcattacaga tctttgagcg agccacagca     2820

acttttctgc caagtcagct tagtttagac ttcagtgaat caggctattg ctatcctaat     2880

gtatgtctct atgagtgtat ttagccacac atctgccctt ggttgacttt ctgactcatt     2940

gcttgcttgc ttgtttcctt gctttggaaa actattgaag attgctaaaa aataccactg     3000

caaagtgatg gaaaagggtg gagaacaggg gagtagccag gctggatggc tcaaatataa     3060

atgaatgagg aattctttat gaagtatcag tcagatttta tgattaagtg atgtaatata     3120

ggaattatgt aaaagggaag aatgtctgat actgatctat tagagaggta ctttagaggc     3180

ttcttgattg gcataaagtt cctaaggtta tagattttcc ccccttttgg ctgtatagca     3240

aagtgtttta atccacggtt gtgccttatt gttccattaa aatt                      3284


<210> 1093
<211> 876
<212> DNA
<213> Homo sapiens

<400> 1093
accacccagt ccagcaccca ccatggctga cgcctgctgc accaggacgt atgtgattgc       60

tgcatccacc atgtctgtct gctccagtga cgtgggccat gtcagccgag tctcctcccc      120

cagcacctgc actggctcct cctggcaggt ggacaattgc caggaaagct gctgcgagcc      180

ccgctcctgt gcctccagct gctgtacccc tagctgctgt gccccagccc cctgcctggc      240

cctggtctgt gccccagtga gctgtgagcc cagcccctgc caatcaggct gcaccgactc      300

ctgcacacct tcatgctgcc agcagtctag ctgccagccg gcttgctgca cctcctcccc      360

ctgccaacag gcctgctgtg tgcctgtgtg ctgcaagtcc aactgctgca agcccgtgtg      420

ctgcgtgtcc atctgctctg gagcttcctc cccatgctgc cagcagtcta gctgccagtc      480

agcttgctgc accttctccc catgccaaca ggcctgctgt gtgcccatct gctgcaagcc      540

catctgctgt gtgcctgtct gctctggggc ttcctctctg tgctgccaga agtctagctg      600

ccagccggct tgctgcacca cctcctgctg cagaccctcc tcctccgtgt ccctcctctg      660

ccgccctgtg tgccggcctg cctgctgtgt gcctgtcccc tcctgttgtg tccctgcctc      720

ctcctgccag cccagctgct gccacccggc ctcctgcctg tccttcctct gccgccccgc      780

gtgctcccgc ctggcctgct gaggcctctg ctcaggccag gagtccagct gctgatgggc      840

acgtccccca gggccagccg gctccggtcc tgtcct                                876


<210> 1094
<211> 254
<212> DNA
<213> Homo sapiens

<400> 1094
cctgaaccat ccatttctga caccatgatt tactacagca actattatgg tggctatggg       60

tatggtgggc ttggctgtgg ctatggctgt ggttatcgtg gctatggatg tggttatggt      120

ggctatggag gctatggaaa tggctactac tgcccatctt gctatggaag atattggtca      180

tatggtttct actgaacaat tctagagctc accagatttg tctgcttgtg aaacctggat      240

tctcatgctg ctct                                                        254


<210> 1095
<211> 1234
<212> DNA
<213> Homo sapiens

<400> 1095
acactcactt acacctcccc cagctcacct cctccccacc ccagcatggc cgcgtccacc       60

atgtctgtct gctccagcgc ttactccgac tcctggcagg tggacgactg cccagagagc      120

tgctgtgagc ccccctgcag cgcccccagc tgctgcgccc cggccccctc cctgagcctg      180

gtctgcaccc cagtgagctg tgtgtccagc ccctgctgcc aggcggcctg tgagcccagc      240

gcctgccaat caggctgcac cagctcctgc acgccgtcat gctgccagca gtctagctgc      300

cagccggctt gctgcacctc ctccccctgc cagcaggcct gctgtgtgcc tgtctgctgc      360

aagactgtct gctgcaagcc tgtgtgctgt gtgcctgtct gctgtggggc tgcttcttcg      420

tgctgccggc agtctagctg ccagccagct tgctgtgcct cttcctcctg ccagccggcc      480

tgctgtgtgc ccgtctgctg caagcctgtg tgctgtgtgt ccacctgctc tgaggattcc      540

tcttcatgct gccagcagtc tagctgccag ccagcttgct gcacctcctc ctcctaccag      600

caggcctgct gcgtgcctgt ctgctgcaag actgtctact gcaagcccat ctgctgtgtg      660

cctgtctgct ctagggcttc ctcttcacgc tgccagcagc ctagctgcca gccagcttgc      720

tgcaccacct cctgctgcag accctcctcc tctgtgtccc tcctctgcca ccccgtgtgc      780

aggtccacct gctgtgtgcc cgtctcctcc tgctgtgccc ccacctcctc ctgccagtcc      840

agctgctgcc gcccggcctc ctgcgtgtcc ctcctctgcc gccccgcaag ctcccgcctg      900

gcctgctaca gcctctgctc aggcaagaag tccagctgct gagtgctcaa tccttgtctc      960

ctgctgactg tgtctttgct gccaagcagg attctccagt ctcaggagcc cctggagtcc     1020

tcagaatcca ccagctccat cagtagccac agagctgctg cctgaagggg attttgagcg     1080

cgtcacactt tcctccccac tgtctgggaa gagacaaccc acaaatccct cagcaggtgg     1140

actgtggctt tctggagccc ccttctccaa atgtgttgct tatacccaat gtgacaaaga     1200

agaactgctc taatcaataa attcttgagt cagg                                 1234


<210> 1096
<211> 2479
<212> DNA
<213> Homo sapiens

<400> 1096
gtcgcacatg cgcacagagc ccgggcggct acggaagcgg tgagactgtc tctcggctgc       60

agccctggtg cgacccggcc cgttgccgta gagatgggca gggctggatg gagtggggtg      120

cggtgagctg agctgaccct gcttcgccac ggggactgca gtgaccccgg cttgccggca      180

gggcgggtaa caggttgagc cagggtgggg ctgctcaggg gcgtggagcc gaggccagga      240

tttctctgaa gacccggcac aggctattcc tttctgcgac gagcccattg ctatggaaac      300

caaagcgtta ggccagcggg gattgaggct gcgggatcat gacgggtctc tctcccgaag      360

aaccttgcct aaggcttccc caagcggcta cttcctgagc gaacccgccc acccgcctga      420

aggagagagt tttccatgga cacagcctag cagaaagacg cagccttcgt gcttcgctga      480

ctgctgacca ctgacccacc gccttgatga cagcaccctc gtgtgccttc ccagttcagt      540

tccggcagcc ctcagtcagc ggcctctcgc agataaccaa aagcctgtat atcagcaatg      600

gtgtggccgc caacaacaag ctcatgctgt ctagcaacca gatcaccatg gtcatcaatg      660

tctcagtgga ggtagtgaac accttgtatg aggatatcca gtacatgcag gtacctgtgg      720

ctgactcccc taactcacgt ctctgtgact tctttgaccc tattgctgac catatccaca      780

gcgtggagat gaagcagggc cgtactttgc tgcactgtgc tgctggtgtg agccgctcag      840

ctgccctgtg cctcgcctac ctcatgaagt accacgccat gtccctgctg gacgcccaca      900

cgtggaccaa gtcatgccgg cccatcatcc gacccaacag cggcttttgg gagcagctca      960

tccactatga gttccaattg tttggcaaga acactgtgca catggtcagt tccccagtgg     1020

gaatgatccc tgacatctat gagaaggaag tccgtttgat gattccactg tgagccatcc     1080

cacgagcccc tgcattggag tcagaggtac agatctattg ttgatcttac accaagatcc     1140

aaacttgaac attctacttt tgttgataca gaaaaaaaca gatgatgcct tttatgagca     1200

caaaaaagag ttgctgtagc ttttaacttt ataatccatt ttttttaaga ttaaactaat     1260

tgtgagatgg tgaagataaa ttttctgccc tgtgagtgac actggccagg ggataggttg     1320

aggcagatgg tgcccagaag aaagagggca gcacccattg cacatggcag gcctggaatc     1380

ctgcagccct ccccaaaaac agattgaccc aggaatgaat ctgctacaat tccacctcat     1440

tctttcacac ccagagccag agccttaagc atcatggtac ctcttgcgct tcttacagtg     1500

agtgccaatc tactagataa atggccttca ggcagtgctc caggaatcct ggggggtccc     1560

aggccacctc tgcttccacc ttcactataa gtggcccagt tctggttttc tagattgtac     1620

ttatgcataa gatagttttt aaagaaagca ttccactgtg taaatttttt tttgtctttt     1680

tttgaaactg tcctgctctg tcacccatcc tagagtgcag tagtgtgatc atggctcact     1740

gtagccacaa cctctcaggc tcaagtgatc ctcttacctt agcctcctgc gtggctggga     1800

ctacagatgt ttgccaccat gcccgcctca ttttttttct ttttttatag agatgagatt     1860

ttactatgtc gcccagactg gtctcaaact cctggcctca agcaatcctc acgcctcagc     1920

ctcccaaagt gttgatgagc cactgtaccc cgataccact gtataaaaaa tttaaaaaaa     1980

attgtgagtg ctattgtaca tggcaaagtt tcaaagagct cttggccatc cctcaccaaa     2040

ctttggcaaa agatggtgtt agtccccttc tccagggcac atgagaaaaa caggcctaac     2100

atcaggtctc agcggttcct ctcacaggcc ttggcttgga aggctggagc ttcggaccaa     2160

ggcccagccc tgtcacctcc tcttcatgtg atgtggaccc ctgggagcat cagtgtcctc     2220

atctgtccaa tgacagccct tttctcacag agttattgtg aagattcaac aatttcttgg     2280

catagtgcct ggcacatggt gtgtgcttag cgcaaatggc agctctcatc atgaatgata     2340

gactctttca ccctgctggt cccaggtcgg cacacacatc cccataatgg catttctcct     2400

ttctgtgcac agcactttat tgttacaaag tactcttcca aaaagttacc ctgtgtgtaa     2460

aaaaaaaaaa aaaaaaaaa                                                  2479


<210> 1097
<211> 199
<212> DNA
<213> Homo sapiens

<400> 1097
caactgagcc tacctttctt gaaaccatga gctttgataa caactaccat ggtggccagg       60

gctatgccaa aggaggcctg ggctgcagct atggctgtgg tcttagcggc tatggctatg      120

cctgctactg cccatggtgt tatgaaagat cttggttttc tggctgcttc tgagaaatta      180

gagattgctg atctgttta                                                   199


<210> 1098
<211> 440
<212> DNA
<213> Homo sapiens

<400> 1098
acaacagcta accacttctg acaacatgag ctactccggc agctactatg gaggcctagg       60

ctacggctgt ggaggattcg gtggcctggg ctatggctat agctgtggat gtggcagctt      120

ccgcagactg ggctatggct gtggctatgg aggctacaga tacagctgct gccacccatc      180

atgctatggg ggatactggt cttctggatt ctattgaata aatacttgaa atatagtctt      240

ctgtgagatt cccaattctt ccaagaaact ttattccata accatatgga attccatatt      300

ccataacaaa acagctgctt ggatcacctg ccttttgaca atagtgtgaa gaaaacttga      360

tcaactagat attggcattt gattagtgat gttctccaga tattcacttt tttattggct      420

ggagagccat tatactctaa                                                  440


<210> 1099
<211> 311
<212> DNA
<213> Homo sapiens

<400> 1099
caaggacaac ctccacaacc atcacgatgt gcggcagcta ctacggaaac tactacggcg       60

accatggcta tgggtgctgt ggatacgaag gcctaggcta tggctatgga agcctgcgct      120

gtggctatag ctcctgctgt ggctatggtc atggctacgg ctcccgcttc ttctgtggct      180

gtggctatgg atgcggctct ggctactact attgaggaca ccgtgggaga ctcatcctct      240

atcctgtgac atcgggattc accaattctg aaccccgtat gctctgagct cggggctgga      300

tgaagattat c                                                           311


<210> 1100
<211> 5586
<212> DNA
<213> Homo sapiens

<400> 1100
aggttcggct gcgcgagcgg agggaggcgg ttccctctta tgcttttcat ctccatcccc       60

agccccaccc acagccaggg ggcttgggtt ctgagctgat ggggtacccc cctctgcaga      120

gcgggatgag tgggtgttcc ggcagggatg tggtcattga cggccagtga gggcgagagt      180

accacggccc acttcttcct tggagctgga gatgaggggc tgggcacccg tggaataggc      240

atgaggccag aagagagtga cagcgagctc cttgaggatg aggaggatga agtgcctcct      300

gaacctcaga tcattgttgg catctgtgcc atgaccaaga aatccaagtc caagccaatg      360

actcaaatcc tagagcgact ctgcagattt gactacctga ctgttgtcat tctgggagaa      420

gatgtaatcc ttaatgaacc tgtggaaaac tggccatcct gccactgcct catctctttc      480

cactccaaag gctttcctct ggacaaagct gttgcttact ccaagcttcg aaaccccttt      540

cttatcaatg atctggccat gcagtattac atccaagata ggagggaggt gtaccggatc      600

ctgcaggaag agggtattga tctgcctcga tatgctgtgc tcaaccgtga tcctgcccgg      660

cctgaggaat gcaacctgat agaaggtgaa gaccaagtag aggtcaatgg agctgtcttt      720

cccaagccct ttgtggagaa gccagtgagt gcagaagacc acaatgttta catctactac      780

cccagctcag ctggaggagg aagccagcgt ctctttcgta agattggcag ccgaagcagt      840

gtttactctc ctgagagcag cgtccgaaag acggggtcgt acatctatga ggagtttatg      900

ccaacagatg gcacagatgt caaggtgtat acagtggggc cagattatgc ccatgctgaa      960

gctagaaaat ctccagcttt ggatgggaag gttgaacgag acagtgaggg gaaagagatt     1020

cgatatccag tcatgctgac tgccatggaa aagctggtgg ccaggaaagt ctgcgtagct     1080

ttcaagcaaa cagtttgtgg atttgacctt cttcgtgcca atggtcattc ctttgtgtgt     1140

gatgtcaatg gctttagttt tgtcaagaac tcgatgaaat actacgatga ctgtgccaag     1200

attctgggga acaccataat gcgggagctt gccccacagt tccagattcc atggtccatc     1260

cccacggagg ctgaggacat tcccattgtt cccaccacat ctggcactat gatggaactt     1320

cgttgtgtca ttgcaattat tcgtcatggg gatcgtactc ccaagcagaa gatgaagatg     1380

gaagtgaaac acccaaggtt ttttgctctg tttgaaaaac atggtggcta caagacaggg     1440

aaattaaaac tcaagcgacc tgagcagctc caggaggtgc tggatatcac aaggctgttg     1500

ttggctgaac tggagaaaga accaggtggt gagatcgagg agaagactgg aaaactagag     1560

cagctgaagt ctgtactgga gatgtatggt cacttctcag gtataaaccg gaaggtacaa     1620

ttgacttact accctcatgg agtaaaagct tctaatgagg ggcaagatcc acagagggaa     1680

actctggccc catctctgtt gctggtactg aagtggggtg gagaactgac tcctgctggc     1740

cgtgttcagg ctgaggagct ggggcgagct tttcgctgca tgtaccctgg aggacagggt     1800

gactatgctg gcttccctgg ttgtgggctg cttcgtctcc atagcacttt ccgccacgat     1860

ctcaagatct atgcctctga tgagggtcgt gttcagatga ctgctgctgc cttcgccaag     1920

ggccttctgg ctctagaagg ggagctgaca cccattttgg tgcaaatggt gaagagtgcc     1980

aacatgaatg ggctactgga cagcgatggg gattccttga gcagctgcca gcaccgggtg     2040

aaggctcggc tgcaccatat tctacagcag gatgcgccct ttggccctga ggactacgat     2100

cagctggctc ccaccagaag tacttccctg ctcaactcca tgactatcat ccagaatcct     2160

gtgaaggtct gtgatcaggt atttgccctg atcgaaaacc tcacccacca gatccgggaa     2220

cgaatgcagg accccaggtc tgtagacctg cagctctacc acagtgagac actagagcta     2280

atgctacagc gttggagcaa gctggagcgt gactttcgac agaagagtgg gcgctatgat     2340

atcagtaaga tccctgacat ctatgactgt gtcaagtatg atgtgcagca caatgggagt     2400

ctgggacttc aaggcacagc agagttgctc cgtctctcta aggcactggc tgatgtggtc     2460

attccccagg agtacgggat cagtcgggag gagaaactgg aaattgctgt gggcttctgt     2520

cttccactgt tgcggaagat actacttgac ctgcagagaa cccacgagga tgagtctgtc     2580

aacaagctgc atcccctgta ctcccgaggc gtgctctccc caggtcgcca cgttcgaacg     2640

cgtctctatt tcaccagtga gagccatgtc cactccctgc tcagtgtctt ccgttatgga     2700

ggacttcttg atgagaccca ggatgcacaa tggcagcgag ctttggatta tcttagtgcc     2760

atctcagagc ttaactacat gacccagatt gtcatcatgc tttatgagga caacacacag     2820

gatcccttat cagaggaacg gttccatgtg gagctacact tcagccccgg agtgaaaggt     2880

gttgaggaag aaggcagtgc cccggctggc tgtggattcc gtccagcctc ttctgagaat     2940

gaggagatga aaaccaacca aggcagtatg gagaacctgt gtccaggaaa ggcatcagat     3000

gaaccagacc gggcattgca gacttcaccc cagcctcctg agggccctgg ccttccgagg     3060

agatcacccc tcattcgtaa ccgaaaagct ggttccatgg aggtactttc tgagacttca     3120

tcctcgaggc ctggtggcta ccggctcttt tcatcttcac ggccacccac agaaatgaag     3180

cagagtggcc taggctcaca gtgcacaggg ctgttcagca ccacagtgct gggtggctcc     3240

tccagtgccc cgaatcttca ggactacgcc cgcagccatg gcaaaaagct accacctgcc     3300

agtctgaagc accgagatgg gtttgaaggg tgttccatgg tgcctaccat ctaccctctg     3360

gaaacactgc ataatgccct ttccctacgt caagtgagtg aattcttgag tagagtctgc     3420

cagcgccaca ctgatgccca ggcacaggca tctgcagccc tctttgattc catgcacagc     3480

agccaggcct cagataaccc attttctcca ccacgtactc ttcattcacc tcccctgcaa     3540

ctccagcagc gctctgagaa gcccccttgg tacagcagtg gcccttctag cactgtgtcc     3600

agtgctggtc cttcttcccc tactacagta gatggtaact cccaatttgg cttcagtgat     3660

caaccctccc taaattcaca cgtggctgaa gaacatcaag gccttgggct gctccaggag     3720

acccctggga gtggagcaca agagctctcc atagaagggg agcaagagct ttttgaacca     3780

aatcagtccc cacaggtgcc acctatggaa accagccagc catacgagga ggtcagccag     3840

ccatgtcagg aggtccctga catcagccag ccatgccagg acatttctga ggcgctcagc     3900

cagccatgtc agaaggtccc tgacatcagc cagcaatgcc aggagaacca tgacaatggt     3960

aaccacacat gccaggaggt ccctcacatc agccagccat gccagaagtc cagccaactg     4020

tgccagaaag tctctgagga agtttgccag ctatgtctgg agaactccga ggaggtcagc     4080

cagccatgcc agggggtctc tgtggaggtt ggcaagctgg tccataagtt ccatgtaggg     4140

gttggtagct tggtccagga aacccttgta gaagttggca gcccagctga agagatccct     4200

gaggaggtca tccagccata ccaggagttc tctgtggagg ttggcaggct ggcccaggag     4260

acttctgcga tcaatctgtt atctcagggc atccctgaga ttgataaacc atcccaagag     4320

ttccctgagg agattgatct gcaggcccag gaggtccctg aggagataaa ttagaagtcc     4380

tgggtggtcc ctgaagtgat tgatcagctg cctggagagg gtattcctca agcccagcat     4440

ccatctggtg atccaaaccc tcagagccag tctctagccc atgaccagca ctcacccctt     4500

ccaccagcaa catgtgatta attttctcat tagtggtatc acactatacc agccatttga     4560

gccagcaacc ttttctgttg gctaactcac tggccagctc tcaccagcgg tgtctgggga     4620

agtagttctc tttgtatgaa gcatacctgt gccagagctg tggttgagga ggagccagtt     4680

ttaggttcga agaagccatt ggctcctcac ttagccatta gacttgaata ggatttcctt     4740

ggggtgggtt ggtctgtcat tacccagcct tctctgagca tcctaggaaa tcacagattg     4800

ttaaaggaaa tgccgcttca ctgctgaaga caccatctgg cgacagcaaa tgcaaaagag     4860

gggactctag ggtcttcact tttctgggga aatgttcacg acttctcaag gtacgcttag     4920

accatatgtg cattcagggg actcttgtct ttgccagcac tcctcaggtg agcccgggat     4980

ggctatctga aatgtctgga aaatagagtc ccttccccaa acatctgaca tggccactaa     5040

atctttagac ttgccttata gatccttcca tatcatcccc aagtgcccct tctgcctcag     5100

tcctgttcct ctgggcaata gctctaggga aaagtaggta ttagactgct gtgcaaaatt     5160

cagagcaact acttaaaatg ctctagagga ttcttagcca gtctgtgaaa gtgggcctcc     5220

tctgtggtgg ggctgtttgg cttaggagat gctgtagtag tagagataat caggttctat     5280

tttaagcaat cagcagagat caatattgta cagatacaag caaaggttta ataaatatat     5340

atatatatat ttatttctgt agttgtgcca gggacagact ggccaaagac caaacactgc     5400

agggtcccca agaaatttgt ccttatatca ttgtgtctga gggccagata tgattatgaa     5460

gctttttcca aagatccagg gatgggaatg ggagtgggta ggaggggtaa tgcggtcatt     5520

ggagtcgggg gctggaacat tatgagtgct caataaatat aaactaatga gaatggtggt     5580

gatgga                                                                5586


<210> 1101
<211> 2311
<212> DNA
<213> Homo sapiens

<400> 1101
gatgtcacgt ccggcggcgg cggcagcggc agcggcagcg gcgctgagtt ttgtctcccg       60

ggccgtctgg gcgcgcgcgg gtgtcccaga atgaaatatg actgaggact ctcagagaaa      120

ctttcgttca gtatattatg agaaagtggg gtttcgtgga gttgaagaaa agaaatcatt      180

agaaattctc ctaaaagatg accgtctgga tactgagaaa ctttgtactt ttagtcagag      240

gttccctctc ccgtccatgt accgtgcatt ggtatggaag gtgcttctag gaatcttgcc      300

tccacaccac gagtccatgc caaggtgatg atgtatcgta aggagcagta cttggatgtc      360

cttcatgccc tgaaagtcgt tcgctttgtt agtgatgcca cacctcaggc tgaagtctat      420

ctccgcatgt atcagctgga gtctgggaag ttacctcgaa gtccctcttt tccactggag      480

ccagatgatg aagtgtttct tgccatagct aaagccatgg aggaaatggt ggaagatagt      540

gtcgactgtt actggatcac ccgacgcttt gtgaaccaat taaataccaa gtaccgggat      600

tccttgcccc agttgccaaa agcgtttgaa caatacttga atctggaaga tggcagactg      660

ctgactcatc tgaggatgtg ttccgcggcg cccaaacttc cttatgatct ctggttcaag      720

aggtgctttg cgggatgttt gcctgaatcc agtttacaga gggtttggga taaagttgtg      780

agtggatcct gtaagatcct agtttttgta gctgtcgaaa ttttattaac ctttaaaata      840

aaagttatgg cactgaacag tgcagagaag ataacaaagt ttctggaaaa tattccccag      900

gacagctcag acgcgatcgt gagcaaggcc attgacttgt ggcacaaaca ctgtgggacc      960

ccggtccatt caagctgaac gcacccgctg gttgtggacc gtctgccagg caccacaatc     1020

attcctggac ccccgagggc ctctgagttt gagacgctgg ctgagatcaa atgataagaa     1080

ttccaatttt tgttttccta agtctttcat ctgctaatct acccaacatg aaccacgggc     1140

cacatgaagg gccagacaca ttcttaagcg gctcacagcc tagaggtgca catctgtgat     1200

tacaatgtgc aaggtaaaac tggatcaaca gtttccaagg actggcatgt aataaaatat     1260

cctcaaaaca acaagcaagt tgggcgtgac ttagactttc actgcccatg tagaaggcac     1320

tgtacattct tgcagcatct cagttggcca gcaagaggtg agtcagaaaa aaaccattca     1380

gcagccacat ggaagtgggg ctcactgggc acaaggcaaa actgtgaaga agataaagtg     1440

tctgtggttc tgcattgact ctattccctg gagtcctccc ctctcgagtt cctagaatta     1500

tgttatcact cttgctctat ctcattccta tcaagacctg ttttagaaat gggtgccaca     1560

gactcagtta cattcaaatg taaacccatt cattcattta gcaagttact tattagtgcc     1620

agtgctgtgt caggttctac attaggtacc agagtacagt gatgagcaaa accagtccct     1680

gcccttctgg aacagagaag actggaagag gatgggggta gccattaatc aaacagtcac     1740

agaaatgagt gcaaaatgta gctggagtaa gggcttccat ggtgaggcac ttggtgcagg     1800

gatctctgga tctgaccaaa tcaggaggtc aggaaaggct tccaggagga agtgacactg     1860

tgcccagagc tcagggatgg aagaaggatg ctccttctgg gcagagagta aggagagaag     1920

attggtggga aggagggcag gggccagatg ccgtgggtgt gatttggatc tgtgtccctg     1980

ccaatcacat gttgaattgt agtccccagt gttggaggtg gagcctggtg ggacatgatt     2040

ggatcatggg ggtagttttt catgaacggt ttagtaccaa ccacttggtg ctgttctagt     2100

gagttgagtg cattctcgcg agatctggtt gtttaaaagt gtgtagcacc cttccctctt     2160

gctcctgctc ctccaatgtg agactccttg ctttccctct gttttccacc atgattggaa     2220

gcttcctgag gcctcaccag aggcagatgc cagcatcatg cttcctgtgc agcctgcaga     2280

actgtgagcc aattaaacct cttttcgtta t                                    2311


<210> 1102
<211> 1260
<212> DNA
<213> Homo sapiens

<400> 1102
tttccttccc aggtgtcgcc gcctgctttc tgcagccgct gcctgggagg ggttccgagg       60

ttctgggcag ccacagcccc ggaggcctta caggagcgac ctggcaattc ccgccgccgg      120

ccgccagagg aagctgcttt gctgctgtcg ttgcccagca actcgtagcc cggaagcagt      180

accccgtctc gctcggttcc gcggcggcca cgctccggga gacttccggc agggcgggcg      240

cggggtcttg gcgaacggtc ttcggaagcg gcggcggcgc gatgaccacg ctacgggcct      300

ttacctgcga cgacctgttc cgcttcaaca acattaactt ggatccactt acagaaactt      360

atgggattcc tttctaccta caatacctcg cccactggcc agagtatttc attgttgcag      420

aggcacctgg tggagaatta atgggttata ttatgggtaa agcagaaggc tcagtagcta      480

gggaagaatg gcacgggcac gtcacagctc tgtctgttgc cccagaattt cgacgccttg      540

gtttggctgc taaacttatg gagttactag aggagatttc agaaagaaag ggtggatttt      600

ttgtggatct ctttgtaaga gtatctaacc aagttgcagt taacatgtac aagcagttgg      660

gctacagtgt atataggacg gtcatagagt actattcggc cagcaacggg gagcctgatg      720

aggacgctta tgatatgagg aaagcacttt ccagggatac tgagaagaaa tccatcatac      780

cattacctca tcctgtgagg cctgaagaca ttgaataacc ctgggcagtg gttcttaggc      840

agatactcta gatgctttat ggacaatatt attttcattg gatgattctg gagctctatt      900

aggagaaaag taatcatttt aggtcttaaa gacttcaaga aaatacaggt tatcaattta      960

ttttaaatct cattgtttcc agttagcaat atcataccta ttaaagctgt tcattgtaac     1020

aaaattcaat caaaaaggca gctaggtcag aaggaaacat accactctca tggttcatag     1080

tattcactgt atgtatgcta gggaaaagac ttgctccagt ctcctcctca gttctgtgcc     1140

tgagaaccac tgctgcatat atttgttttt aaattttgta ttgaactgtt aattgaagct     1200

ttaaaagcat atatgaaatg tataaatcta agatgtataa tacattattg actctatgaa     1260


<210> 1103
<211> 3357
<212> DNA
<213> Homo sapiens

<400> 1103
gcggccgccg tagttgaatc tcctcggcgc cggaagcccc gccactccgc ttcctggttc       60

atgtgcggcc ttcgttccct cgctatctcg accttgactt cgcatgtgca tccgccgaag      120

tctttctaga tcaatcggcc ccatctctcg tcttcccgat tcggccatga cctcacccgt      180

atcctcgacg taggacctcg gacttcattt ccgccacccc gacacttccg gaatccccgg      240

aagcgacccg ttgccatggc gactatgtac acagccaggc agccccgcgt ggggagtgca      300

ggtggtttcg gttgcggcag tcgcgtcccg ggagcgtcgc tgcctggtga acgctagaat      360

gggtactagg aaaaaagttc atgcatttgt ccgtgtcaaa cccaccgatg actttgctca      420

tgaaatgatc agatacggag atgacaaaag aagcattgat attcacttaa aaaaagacat      480

tcggagagga gttgtcaata accaacagac agactggtcg tttaagttgg atggagttct      540

tcacgatgcc tcccaggact tggtttatga gacagttgca aaggatgtgg tttctcaggc      600

cctcgatggc tataatggca ccatcatgtg ttatgggcag acgggagctg gcaagacata      660

caccatgatg ggggcaactg agaattacaa gcaccggggg atcctccctc gtgccctgca      720

gcaggttttt aggatgatcg aagaacgccc cacacatgcc atcactgtgc gtgtttccta      780

cttggaaatc tataatgaga gcctgtttga tctcctgtcc actctgccct atgttggacc      840

ctcagtcaca ccaatgacca tcgtggaaaa ccctcaagga gtcttcatta agggcttgtc      900

agttcacctc acaagtcagg aggaggatgc attcagcctc ctttttgagg gtgagaccaa      960

caggattata gcctcccaca ctatgaacaa aaactcttcc agatcacact gcattttcac     1020

catctactta gaggcccatt cccggacctt atcagaggaa aagtacatca cttccaaaat     1080

taacttggtg gatctggcag gctcagagag gctggggaag tctgggtctg agggccaagt     1140

cctgaaggaa gccacctaca tcaacaaatc gctctcattc ctggagcagg ccatcattgc     1200

ccttggggac cagaagcggg accacatccc ctttcggcag tgcaagctca cccacgctct     1260

gaaggactcg ttagggggaa actgcaatat ggtcctcgtg acaaacatct atggagaagc     1320

tgcccagtta gaagaaacgc tatcttcact gagatttgcc agcaggatga agctagtcac     1380

cactgagcct gccatcaatg aaaagtatga tgctgagaga atggtcaaga acctggagaa     1440

ggaactagca ctactcaagc aggagctggc tatccatgac agcctgacca accgcacctt     1500

tgtgacctat gaccccatgg atgaaatcca gattgctgag atcaactccc aggtgcggag     1560

gtacctggag gggacactgg acgagatcga cataatcagc cttagacaga tcaaggaggt     1620

gttcaaccag ttccgggtgg ttctgagcca acaggaacag gaagtggagt ccactttgcg     1680

caggaagtac accctcattg acaggaatga ctttgcagcc atttctgcta tccagaaggc     1740

ggggcttgtg gatgttgatg gccacctagt gggtgagcct gaaggacaaa actttggact     1800

cggagtcgcc cctttctcta ccaaacctgg gaagaaagcc aagtccaaga agacattcaa     1860

agagccactc agctccttgg caagaaagga aggtgccagc agccctgtga atgggaagga     1920

cttggattac gtttccacct ccaagaccca gctggtccca tcctccaaag atggggatgt     1980

caaagacatg ctttcgcggg accgggaaac ttccagcatt gagccccttc cctcagactc     2040

cccgaaggag gaattacgcc caattaggcc cgacacccca ccctccaaac cagtggcctt     2100

tgaggagttt aagaatgagc aaggtagtga gatcaaccga attttcaaag aaaacaaatc     2160

catcttgaat gaacggagga aaagggccag cgagaccaca cagcacatca atgccatcaa     2220

gcgggagatt gatgtgacca aggaggccct gaatttccag aagtcactac gggagaagca     2280

aggcaagtac gaaaacaagg ggctgatgat catcgatgag gaagaattcc tgctgatcct     2340

caagctcaaa gacctcaaga agcagtaccg cagcgagtac caggacctgc gtgacctcag     2400

ggctgagatc cagtattgcc agcacctagt ggatcagtgt cgccaccgcc tgctcatgga     2460

atttgacatc tggtacaatg agtcctttgt catccctgag gacatgcaga tggcactgaa     2520

gccaggcggc agcatccggc caggcatggt ccctgtgaac aggattgtgt ctctgggaga     2580

agatgaccag gacaaattca gccagctgca gcagagggtg cttcctgagg gccctgattc     2640

catctccttc tacaatgcca aagtcaagat agagcagaag cataattact tgaaaaccat     2700

gatgggcctc cagcaggcac atagaaaata gaacctcatc gccagtacct taaaggacaa     2760

gaccagcaac tcccacctac tgtagtggag ctgctcaacc acctgcccag agctgcagcc     2820

ccctctactc caatgctggg acccagcaca gagaacacat ttggcctgca tgttgggagg     2880

agcatcctcc aaggacaacc ttgctcatct ccacagagca ctttgggttt taattcactg     2940

tcttatatgc agggacagga taaaataact ttctagtttg gactttcagt gctcatctga     3000

gaactttgtc ttatttcctg tctgaaagga catattctct atgtatgtgt gaggtcagaa     3060

ctgagtctca agtaggaagg cagaaaagta gctcagccag gctcctcctg gcaggccttt     3120

gtcacactgg tcagcccctt tcctggatag acatcctagg gtgggggtgg tgagctcggt     3180

ctgaggagct ctgcttctca cagctccctc agaccctaag ttctctcaag acatcttttc     3240

tgtgtttctg agccagtgaa gaagacagga ggaggccctc cttcatttgg caaccagggg     3300

aggataaggt ctagccacag agaccagaaa gggatgaggc agagctggct ccatgta        3357


<210> 1104
<211> 3771
<212> DNA
<213> Homo sapiens

<400> 1104
gattgggccg ctgtcaggtg tcgctgcctg caggttcggc tgcgcgagcg gagggaggcg       60

ggactcaaga gtagccttcc tcgaggacct gcctttccca tttgctgcct gaagttaatg      120

tttcttgctg gccaaatcag ggacatgccg gcattagcgg gatgagtggg tgttccggca      180

gggatgtggt cattgacggc cagtgagggc gagagtacca cggcccactt cttccttgga      240

gctggagatg aggggctggg cacccgtgga ataggcatga ggccagaaga gagtgacagc      300

gagctccttg aggatgagga ggatgaagtg cctcctgaac ctcagatcat tgttggcatc      360

tgtgccatga ccaagaaatc caagtccaag ccaatgactc aaatcctaga gcgactctgc      420

agatttgact acctgactgt tgtcattctg ggagaagatg taatccttaa tgaacctgtg      480

gaaaactggc catcctgcca ctgcctcatc tctttccact ccaaaggctt tcctctggac      540

aaagctgttg cttactccaa gcttcgaaac ccctttctta tcaatgatct ggccatgcag      600

tattacatcc aaggtgacag gagggaggtg taccggatcc tgcaggaaga gggtattgat      660

ctgcctcgat atgctgtgct caaccgtgat cctgcccggc ctgaggaatg caacctgata      720

gaaggtgaag accaagtaga ggtcaatgga gctgtctttc ccaagccctt tgtggagaag      780

ccagtgagtg cagaagacca caatgtttac atctactacc ccagctcagc tggaggagga      840

agccagcgtc tctttcgtaa gattggcagc cgaagcagtg tttactctcc tgagagcagc      900

gtccgaaaga cggggtcgta catctatgag gagtttatgc caacagatgg cacagatgtc      960

aaggtgtata cagtggggcc agattatgcc catgctgaag ctagaaaatc tccagctttg     1020

gatgggaagg ttgaacgaga cagtgagggg aaagagattc gatatccagt catgctgact     1080

gccatggaaa agctggtggc caggaaagtc tgcgtagctt tcaagcaaac agtttgtgga     1140

tttgaccttc ttcgtgccaa tggtcattcc tttgtgtgtg atgtcaatgg ctttagtttt     1200

gtcaagaact cgatgaaata ctacgatgac tgtgccaaga ttctggggaa caccataatg     1260

cgggagcttg ccccacagtt ccagattcca tggtccatcc ccacggaggc tgaggacatt     1320

cccattgttc ccaccacatc tggcactatg atggaacttc gttgtgtcat tgcaattatt     1380

cgtcatgggg atcgtactcc caagcagaag atgaagatgg aagtgaaaca cccaaggttt     1440

tttgctctgt ttgaaaaaca tggtggctac aagacaggga aattaaaact caagcgacct     1500

gagcagctcc aggaggtgct ggatatcaca aggctgttgt tggctgaact ggagaaagaa     1560

ccaggtggtg agatcgagga gaagactgga aaactagagc agctgaagtc tgtactggag     1620

atgtatggtc acttctcagg tataaaccgg aaggtacaat tgacttacta ccctcatgga     1680

gtaaaagctt ctaatgaggg gcaagatcca cagagggaaa ctctggcccc atctctgttg     1740

ctggtactga agtggggtgg agaactgact cctgctggcc gtgttcaggc tgaggagctg     1800

gggcgagctt ttcgctgcat gtaccctgga ggacagggtg actatgctgg cttccctggt     1860

tgtgggctgc ttcgtctcca tagcactttc cgccacgatc tcaagatcta tgcctctgat     1920

gagggtcgtg ttcagatgac tgctgctgcc ttcgccaagg gccttctggc tctagaaggg     1980

gagctgacac ccattttggt gcaaatggtg aagagtgcca acatgaatgg gctactggac     2040

agcgatgggg attccttgag cagctgccag caccgggtga aggctcggct gcaccatatt     2100

ctacagcagg atgcgccctt tggccctgag gactacgatc agctggctcc caccagaagt     2160

acttccctgc tcaactccat gactatcatc cagaatcctg tgaaggtctg tgatcaggta     2220

tttgccctga tcgaaaacct cacccaccag atccgggaac gaatgcagga ccccaggtct     2280

gtagacctgc agctctacca cagtgagaca ctagagctaa tgctacagcg ttggagcaag     2340

ctggagcgtg actttcgaca gaagagtggg cgctatgata tcagtaagat ccctgacatc     2400

tatgactgtg tcaagtatga tgtgcagcac aatgggagtc tgggacttca aggcacagca     2460

gagttgctcc gtctctctaa ggcactggct gatgtggtca ttccccagga gtacgggatc     2520

agtcgggagg agaaactgga aattgctgtg ggcttctgtc ttccactgtt gcggaagata     2580

ctacttgacc tgcagagaac ccacgaggat gagtactccc gaggcgtgct ctccccaggt     2640

cgccacgttc gaacgcgtct ctatttcacc agtgagagcc atgtccactc cctgctcagt     2700

gtcttccgtt atggaggact tcttgatgag acccaggatg cagaccgggc attgcagact     2760

tcaccccagc ctcctgaggg ccctggcctt ccgaggagat cacccctcat tcgtaaccga     2820

aaagctggtt ccatggaggt actttctgag acttcatcct cgaggcctgg tggctaccgg     2880

ctcttttcat cttcacggcc acccacagaa atgaagcaga gtggcctagg ctcacagtgc     2940

acagggctgt tcagcaccac agtgctgggt ggctcctcca gtgccccgaa tcttcaggac     3000

tacgcccgca gccatggcaa aaagctacca cctgccagtc tgaagcaccg agatgagctc     3060

ttgtttgtcc cggccgtaaa acgattttct gtgtcgtttg caaagcatcc gactaacggg     3120

tttgaagggt gttccatggt gcctaccatc taccctctgg aaacactgca taatgccctt     3180

tccctacgtc aagtgccacc tatggaaacc agccagccat acgaggaggt cagccagcca     3240

tgtcaggagg tccctgacat cagccagcca tgccaggaca tttctgaggc gctcagccag     3300

ccatgtcaga aggtccctga catcagccag caatgccagg agaaccatga caatggtaac     3360

cacacatgcc aggaggtccc tcacatcagc cagccatgcc agaagtccag ccaactgtgc     3420

cagaaagtct ctgaggaagt ttgccagcta tgtctggaga actccgagga ggtcagccag     3480

ccatgccagg gggtctctgt ggaggttggc aagctggtcc ataagttcca tgtaggggtt     3540

ggtagcttgg tccaggaaac ccttgtagaa gttggcagcc cagctgaaga gatccctgag     3600

gaggtcatcc agccatacca ggagttctct gtggaggttg gcaggctggc ccaggagact     3660

tctgcgatca atctgttatc tcagggcatc cctgagattg ataaaccatc ccaagagttc     3720

cctgaggaga ttgatctgca ggcccaggag gtccctgagg agataaatta g              3771


<210> 1105
<211> 308
<212> DNA
<213> Homo sapiens

<400> 1105
cctcagaagc atcttcttga aacccatctc aattctctcc tcttgacaac atgtgttgca       60

actactacgg caactcctgt ggctatggct ccggctgtgg ctgtggctat ggctctggct      120

ctggctgtgg ctgtggctat ggaactggct atggctgtgg gtatggctgt gggtttggct      180

cccattatgg ctgtggttat ggaactggct atggctgtgg atatggctct ggctctggct      240

actgtggcta ccggccattt tgctttagaa gatgctattc ttcctgctaa aacatcactg      300

tcggagga                                                               308


<210> 1106
<211> 1941
<212> DNA
<213> Homo sapiens

<400> 1106
cttctccctg gtcaaccgct ctgcaaacaa ccatcaatct gatcccacag gcctgagaaa       60

gtctgctctc cagtacctgc tgctgatctg tttcagccga caagaggcac catgaaattg      120

gaattcacgg agaaaaacta caatagcttc gtgctgcaga acctgaacag acagaggaaa      180

cgcaaagagt actgggacat ggccctgagt gtggacaacc acgtcttctt tgcacatcgc      240

aatgtgctgg ctgctgtctc cccactggtg aggagcctca tctccagcaa tgacatgaag      300

accgctgatg agcttttcat caccattgac accagttacc tgagcccggt cacagtggac      360

cagcttctgg actacttcta tagcggcaag gtggtgatct ccgagcaaaa tgtggaggag      420

ctgcttcgtg gggctcagta tttcaacaca ccacgccttc gagttcactg taacgacttc      480

cttattaagt ccatctgccg tgccaactgc ttgcgctacc tcttcttggc tgagctgttt      540

gagctcaaag aggtatcaga cgtagcttac tctggcattc gggacaactt ccactactgg      600

gccagtcctg agggctccat gcacttcatg cgctgtccac ctgttatctt tggccgcctg      660

ctccgtgatg aaaaccttca cgtgctcaat gaagaccagg cgctcagcgc actcatcaat      720

tgggtgtact tccggaagga ggatcgggag aagtatttca agaagttctt caattacatc      780

aatctcaatg ctgtctccaa taagacgctg gtgtttgcca gcaacaagct ggtgggcatg      840

gagaacacct catcccatac aaccctgatt gagagtgtcc tgatggaccg caagcaggag      900

cggccatgca gcctgctggt ctaccagcgg aaaggggccc tgcttgattc cgtggtcatc      960

ctcggtggcc agaaggccca cggccagttc aatgatggag tgtttgctta tatcatccag     1020

gagaacctgt ggatgaagct ctcagacatg ccctatcggg cagcagcact tagtgccacc     1080

tctgctggtc gctacatcta catctctggt ggcaccactg agcagatttc agggctgaag     1140

acagcctggc ggtatgacat ggatgacaac tcctggacca agttgcctga cctgcccatc     1200

gggcttgtct tccacaccat ggtgacctgt ggggggacag tgtactcagt gggcgggagc     1260

attgccccaa ggcggtatgt ctccaacatc tatcgctatg atgagcggaa ggaagtctgg     1320

tgcctggcag gaaagatgag catccccatg gatggcaccg ccgtgatcac taaaggagac     1380

aggcatctgt acattgtcac tggacggtgc ttggtgaaag gttatatctc ccgggtcggg     1440

gtagtggact gctttgacac cagcactggg gacgtggtcc agtgtatcac cttccccatt     1500

gagttcaacc atcggcccct gctctctttc caacaggaca acatcctctg cgtgcacagc     1560

caccggcaga gtgtggaaat caatctgcag aaggtgaagg caagcaagac gaccacctca     1620

gtgcctgtct tgcccaacag ctgccccttg gatgtgtccc atgctatatg ctccattgga     1680

gacagcaagg tgtttgtatg tgggggtgtc accactgcca gcgatgtcca gacaaaggac     1740

tacaccatca atccaaatgc cttcttgctg gaccaaaaga caggcaagtg gaagaccctg     1800

gctcctccac cagaggcact ggactgtcct gcctgctgtc tagccaagct accttgcaag     1860

attcttcaaa ggatttaaac attttaagtg ggagaataag taaatgcatt attattcacg     1920

atttaatgag agaaagagag g                                               1941


<210> 1107
<211> 2332
<212> DNA
<213> Homo sapiens

<400> 1107
ggtgggcccg cggaggaaag atactgggga gtgggagccg cggggttcag agcgatgatt       60

cccccacagg aggcatccgc tcgacggcgg gagattgagg acaagctgaa gcaggaggag      120

gagactctgt ccttcatccg agacagcctg gagaagagcg accagctcac taagaacatg      180

gtgtctatct tatcatcctt tgagagccgc cttatgaagc tggagaactc catcatccct      240

gtgcacaagc agacggagaa tctgcagcgg ctgcaggaga atgttgagaa gacgctgtcc      300

tgcctggacc atgtcatcag ctactaccat gtggccagtg acactgagaa gatcatcaga      360

gagggcccca caggtaggct ggaagagtac ctgggaagca tggccaagat tcagaaggca      420

gtggagtatt tccaggacaa cagcccagac agcccggaac tcaacaaagt gaaactgctc      480

tttgagcgcg ggaaggaggc cctggagtcc gaatttcgca gcctgatgac gcggcacagt      540

aaggtcgtct cgcccgtgct catcttggat ctgatcagtg gtgacgatga tctggaggcc      600

caggaggacg tgaccctgga gcacctgccc gagagcgtgc tccaggatgt cattcgcatc      660

tcccgctggc tggtggaata tggccgcaac caagatttca tgaacgtcta ctaccagata      720

cgctccagcc agctggaccg ctccatcaaa ggactgaagg agcatttcca taagagcagt      780

tcttcctctg gggttcccta ctcccctgct atccccaaca agaggaaaga cacacctacc      840

aagaagccag tcaagcggcc agggacgatc cgtaaggctc agaaccttct gaaacagtat      900

tcccagcatg gtctagatgg gaaaaagggg ggctctaacc tcattcctct ggaagggctt      960

cttccctgta ccccaagggg cggcctgcct ggcccctgga taaacgctgc ttgtgtttgt     1020

gcggccgaca tctcgccagg tcacgagcat gatttccgag ttaagcacct gtccgaggcc     1080

ttgaacgaca agcacgggcc gctggccggg agagatgaca tgctggacgt ggagaccgat     1140

gcctacatcc actgcgtcag tgccttcgtc aagctggcgc agagcgagta ccagctgctg     1200

gccgacatca tccccgagca ccaccagaag aagaccttcg actccctgat acaggatgcc     1260

ctggatgggc tgatgcttga aggggagaac atcgtgtctg ctgcccggaa ggccattgtg     1320

cgacacgact tctccacggt gctcaccgtc ttccccatcc tgcgacacct caagcagacc     1380

aagcctgagt ttgaccaggt gctccagggc acggctgcca gcacaaagaa caagctgcct     1440

ggcctcatca catccatgga gaccatcggt gccaaagcgc tggaggactt cgcagacaac     1500

atcaagaatg acccggacaa ggagtacaac atgccgaagg acggcaccgt acacgagctc     1560

accagcaatg ccatcctctt cctgcagcag cttttggact tccaggagac ggcaggcgcc     1620

atgctggcct cccaagagac cagctcttcg gccaccagct acagctctga gttcagcaag     1680

cggctgctaa gcacctatat ctgtaaagtg ctgggcaacc tgcagttgaa cttgctgagc     1740

aagtccaagg tgtacgagga cccagctctg agcgccatct tcctgcacaa caactacaat     1800

tacatcctca agtccctgga gaagtctgaa ctgatccagc tggtggcagt gacacagaag     1860

actgctgagc gctcctaccg ggagcacatt gagcagcaga tccagaccta ccagcgcagc     1920

tggttaaagg tgactgatta catcgcagag aagaatctac ctgtgttcca gccgggagtc     1980

aagctccggg acaaggagcg gcagattatc aaggagcgtt ttaagggctt caatgatggc     2040

ctcgaagaac tgtgcaaaat ccagaaggcc tgggctattc cagacacaga gcagagggac     2100

aggattcgcc aggcccagaa gaccattgtc aaggagacct acggggcctt tctacagaag     2160

tttggcagcg tgcccttcac caagaacccg gagaagtaca tcaagtacgg ggtggagcag     2220

gtgggcgaca tgatcgatcg ccttttcgac acctctgcct gagcctgctg ctagccctgc     2280

ctggttccac cagactggcg tgtcattgga cagataaacc agtgttagct tg             2332


<210> 1108
<211> 378
<212> DNA
<213> Homo sapiens

<400> 1108
atggccggag ctggaccgac catgctgcta cgagaagaga atggctgttg cagtcggcgt       60

cagagcagct ccagtgctgg ggattcggac ggagagcgcg aggactcggc ggctgagcgc      120

gcccgacagc agctagaggc gctgctcaac aagactatgc gcattcgcat gacagatgga      180

cggacactgg tcggctgctt cctctgcact gaccgtgact gcaatgtcat cctgggctcg      240

gcgcaggagt tcctcaagcc gtcggattcc ttctctgccg gggagccccg tgtgctgggc      300

ctggccatgg tacccggaca ccacatcgtt tccattgagg tgcagaggga gagtctgacc      360

gggcctccgt atctctga                                                    378


<210> 1109
<211> 1141
<212> DNA
<213> Homo sapiens

<400> 1109
gcggccgcgg agccccaccc gctcctactc cagtcctctc acgcccactg acttaccctg       60

cgcacgcgcg ctgaggctcc gtggggccgc cgcgggcccc gccccgaggt gggagggcct      120

gacgcatcca cagctggcca atcggcggat ggcctcgcgc gcccgccccc tccccctgcc      180

cccggcgccg ggctccacgt gccagtgttt gtgtacgtgc ggccgtggcg gggctggaca      240

gggtccgggt cgttgaggat taggctgctc gggcgtaacc ggagctgggg cgcggctgcc      300

aagggccggc ccggaagtcc cagcggtctt taaattctcc cgtgctaggg ccagcctgcg      360

cattcttacc tgtcggggtg cggcgagtgt ctcacctctc tgcacttcca aggactcttg      420

tcatctgcct taggcgggaa atgctgttgc tggattgcaa ccccgaggtg gatggtctga      480

agcatttgct ggagacaggg gcctcggtca acgcaccccc ggatccctgc aagcagtcgc      540

ctgtccactt agccgcagga agcggccttg cttgctttct tctctggcag ctgcaaacgg      600

gcgctgacct caaccagcag gatgttttag gagaagctcc actacacaag gcagcaaaag      660

ttggaagcct ggagtgccta agcctgcttg tagccagtga tgcccaaatt gatttatgta      720

ataagaacgg gcaaacagct gaagatctcg cttggtcatg tggatttcca gactgtgcca      780

agtttcttac aacaattaaa tgtatgcaga caataaaagc aagtgaacac cctgacagga      840

atgattgtgt tgccgtgctc agacagaaac ggagtctcgg aagtgtagaa aataccagtg      900

ggaaaaggaa gtgctgatgt cacgtgggtt atgaagaagt ctgaagaacg ccttcatttc      960

atgcaaatct ataagctcct gcttttggct ttaccatatg ttgtgtctaa tctccttctg     1020

agaaggacga aaaactttct tccaagtgaa gatccattta agaacacatg tatttacatg     1080

cctataatat gctggttgtg tatgctttgt cttttaagtt attaaaggaa cgtctaaaaa     1140

a                                                                     1141


<210> 1110
<211> 9766
<212> DNA
<213> Homo sapiens

<400> 1110
ggctgaaggc gatccggagt ggggccccag caattcggat tgagccttct ccctccaccc       60

gcttccgtcg gccgggcccc tcccgcccgg ccccgcgggc ctccccaccc ggccccggcg      120

ctccccaccg ccccccctgc gcccgcccct cccccttcgc tttccttctc cccccgcctc      180

ggctccgaca tgaggggccg gcggggcagg ccgcccaagc agcccgcggc tcccgctgcg      240

gagcgctgcg ccccggcccc gccgccaccg ccgccgccgc ccacgtccgg acccatcggg      300

gggctccgct cgcggcaccg cggcagcagc cggggcaggt gggccgccgc ccaggctgag      360

gtggcgccca agacgcggct gagctcgccc agggggggca gcagtagccg gaggaagccg      420

ccgccgccgc cgccggcccc ccccagcacc agcgccccgg gccggggggg gcgaggaggc      480

gggggcggca ggacgggggg cgggggcggc ggcggccacc tggcccggac caccgcggcc      540

cggagggccg tcaacaaagt ggtgtacgat gaccacgaga gcgaggagga ggaggaagag      600

gaggacatgg tctccgagga ggaggaggag gaggacggcg acgccgagga gacccaggat      660

tctgaggacg acgaggagga tgagatggaa gaggacgacg atgactccga ttatccggag      720

gagatggaag acgacgacga cgacgccagt tactgcacgg aaagcagctt caggagccat      780

agtacctaca gcagcactcc aggtaggcga aaaccaagag tacatcggcc tcgttctcct      840

atattggaag aaaaagacat cccgcccctt gaatttccca agtcctctga ggatttaatg      900

gtgcctaatg agcatataat gaatgtcatt gccatttacg aggtactgcg gaactttggc      960

actgttttga gattatctcc ttttcgcttt gaggactttt gtgcagctct ggtgagccaa     1020

gagcagtgca cactcatggc agagatgcat gttgtgcttt tgaaagcagt tctgcgtgaa     1080

gaagacactt ccaatactac ctttggacct gctgatctga aagatagcgt taattccaca     1140

ctgtatttca tagatgggat gacgtggcca gaggtgctgc gggtgtactg tgagagtgat     1200

aaggagtacc atcacgttct tccttaccaa gaggcagagg actacccata tggaccagta     1260

gagaacaaga tcaaagttct acagtttcta gtcgatcagt ttcttacaac aaatattgct     1320

cgagaggaat tgatgtctga aggggtgata cagtatgatg accattgtag ggtttgtcac     1380

aaacttgggg atttgctttg ctgtgagaca tgttcagcag tataccattt ggaatgtgtg     1440

aagccacctc ttgaggaggt gccagaggac gagtggcagt gtgaagtctg tgtagcacac     1500

aaggtgcctg gtgtgactga ctgtgttgct gaaatccaaa aaaataaacc atatattcga     1560

catgaaccta ttggatatga tagaagtcgg aggaaatact ggttcttgaa ccgaagactc     1620

ataatagaag aagatacaga aaatgaaaat gaaaagaaaa tttggtatta cagcacaaag     1680

gtccaacttg cagaattaat tgactgtcta gacaaagatt attgggaagc agaactctgc     1740

aaaattctag aagaaatgcg tgaagaaatc caccgacaca tggacataac tgaagacctg     1800

accaataagg ctcggggcag taacaaatcc tttctggcgg cagctaatga agaaattttg     1860

gaatccataa gagccaaaaa gggagacatt gataatgtta aaagcccaga agaaacagaa     1920

aaagacaaga atgagactga gaatgactct aaagatgctg agaaaaacag agaagaattt     1980

gaagaccagt cccttgaaaa agacagtgac gacaaaacac cagatgatga ccctgagcaa     2040

ggaaaatctg aggagccaac agaagttggg gataaaggta actctgtgtc agcaaatctt     2100

ggcgacaaca caacaaatgc aacttcagaa gagactagtc cctctgaagg gaggagccct     2160

gtggggtgtc tctcagaaac ccccgatagc agcaacatgg cagagaagaa ggtggcatct     2220

gagctccccc aggatgtgcc agaagaacct aacaagacat gtgagagcag taacactagt     2280

gctaccacta cctccatcca gcctaatctg gaaaacagta acagcagcag tgaactaaat     2340

tcttcccaga gtgaatctgc taaggcagct gatgatcctg aaaatggaga aagagaatct     2400

catacacctg tctctattca ggaagagata gtaggtgatt tcaaatcgga gaagtccaac     2460

ggggagctaa gtgaatctcc tggagctgga aaaggagcat ctggctcaac tcgaatcatc     2520

accagattgc ggaatccaga tagcaaactt agtcagctga agagccagca ggtggcagcc     2580

gctgcacatg aagcaaataa attatttaag gagggcaaag aggtactggt agttaactct     2640

caaggagaaa tttcacggtt gagcaccaaa aaggaagtga tcatgaaagg aaatatcaac     2700

aattatttta aattgggtca agaagggaag tatcgcgtct accacaatca atactccacc     2760

aattcatttg ctttgaataa gcaccagcac agagaagacc atgataagag aaggcatctt     2820

gcacataagt tctgtctgac tccagcagga gagttcaaat ggaacggttc tgtccatggg     2880

tccaaagttc ttaccatatc tactctgaga ctgactatca cccaattaga aaacaacatc     2940

ccttcatcct ttcttcatcc caactgggca tcacataggg caaattggat caaggcagtt     3000

cagatgtgta gcaaacccag agaatttgca ttggctttag ccattttgga gtgtgcagtt     3060

aaaccagttg tgatgctacc aatatggcga gaatctttag gacataccag gttacaccgg     3120

atgacatcaa ttgaaagaga agaaaaggag aaagtcaaaa aaaaagagaa gaaacaggaa     3180

gaagaagaaa cgatgcagca agcgacatgg gtaaaataca catttccagt taagcatcag     3240

gtttggaaac aaaaaggtga agagtacaga gtgacaggat atggtggttg gagctggatt     3300

agtaaaactc atgtttatag gtttgttcct aaattgccag gcaatactaa tgtgaattac     3360

agaaagtcgt tagaaggaac caaaaataat atggatgaaa atatggatga gtcagataaa     3420

agaaaatgtt cacgaagtcc aaaaaaaata aaaatagagc ctgattctga aaaagatgag     3480

gtaaaaggtt cagatgctgc aaaaggagca gaccaaaatg aaatggatat ctcaaagatt     3540

actgagaaga aggaccaaga tgtgaaggag ctcttagatt ctgacagtga taaaccctgc     3600

aaggaagaac caatggaagt agacgatgac atgaaaacag agtcacatgt aaattgtcag     3660

gagagttctc aagtagatgt ggtcaatgtt agtgagggtt ttcatctaag gactagttac     3720

aaaaagaaaa caaaatcatc caaactagat ggacttcttg aaaggagaat taaacagttt     3780

acactggaag aaaaacagcg actcgaaaaa atcaagttgg agggtggaat taagggtata     3840

ggaaagactt ctacaaattc ttcaaaaaat ctctctgaat caccagtaat aacgaaagca     3900

aaagaagggt gtcagagtga ctcgatgaga caagaacaga gcccaaatgc aaataatgat     3960

caacctgagg acttgattca gggatgttca gaaagtgatt cctcagttct tagaatgagt     4020

gatcctagtc ataccacaaa caaactttat ccaaaagatc gagtgttaga tgatgtctcc     4080

attcggagcc cagaaacaaa atgtccgaaa caaaattcca ttgaaaatga catagaagaa     4140

aaagtctctg accttgccag tagaggccag gaacccagta agagtaaaac aaaaggaaat     4200

gattttttca tcgatgactc taaactagcc agtgcagatg atattggtac tttgatctgt     4260

aagaacaaaa aaccgctcat acaggaggaa agtgacacca ttgtttcttc ttccaagagt     4320

gctttacatt catcagtgcc taaaagtacc aatgacagag atgccacacc tctgtcaaga     4380

gcaatggact ttgaaggaaa actgggatgt gactctgaat ctaatagcac tttggaaaat     4440

agttctgata ccgtgtctat tcaggatagc agtgaagaag atatgattgt tcagaatagc     4500

aatgaaagca tttctgaaca gttcagaact cgagaacaag atgttgaagt cttggagccg     4560

ttaaagtgtg agttggtttc tggtgagtcc actggaaact gtgaggacag gctgccggtc     4620

aaggggactg aagcaaatgg taaaaaacca agtcagcaga agaaattaga ggagagacca     4680

gttaataaat gtagtgatca aataaagcta aaaaatacca ctgacaaaaa gaataatgaa     4740

aatcgagagt ctgaaaagaa aggacagaga acaagtacat ttcaaataaa tggaaaagat     4800

aataaaccca aaatatattt gaaaggtgaa tgcttgaaag aaatttctga gagtagagta     4860

gtaagtggta atgttgaacc aaaggttaat aatataaata aaataatccc tgagaatgat     4920

attaaatcat tgactgttaa agaatctgct ataaggccat tcattaatgg tgatgtcatc     4980

atggaagatt ttaatgaaag aaacagctcc gaaacaaaat cgcatttgct gagttcttca     5040

gatgctgaag gtaactaccg agatagcctt gagaccctgc catcaaccaa agagtctgac     5100

agtacacaga cgaccacacc ctcagcatct tgtccagaaa gcaattcagt taatcaggta     5160

gaagatatgg aaatagaaac ctcagaagtt aagaaagtta cttcatcacc tattacttct     5220

gaagaggaat ctaatctcag taatgacttt attgatgaaa atggtctgcc catcaacaaa     5280

aatgaaaatg tcaatggaga atctaaaaga aaaaccgtca tcacagaagt caccacgatg     5340

acctccacag tggccacaga atcaaaaact gtgatcaagg tagaaaaagg cgataagcaa     5400

actgtggttt cttccacaga aaattgtgca aaatccactg tcacaaccac cactacaaca     5460

gtgaccaagc tttccacacc ctccacaggc ggcagtgtgg acatcatctc tgtaaaggag     5520

cagagcaaaa ccgtggtcac cacgacagtg acagactccc tgaccaccac gggaggcaca     5580

ctggttacat ctatgactgt gagcaaagag tattccacac gagacaaagt gaaactgatg     5640

aaattttcaa gaccaaagaa gactcgttca ggtacagctc tgccatccta tagaaaattt     5700

gttaccaaga gcagcaagaa gagcattttt gttttgccta atgatgactt aaaaaagttg     5760

gcccgaaaag gaggaatccg agaggtccct tattttaatt acaatgcaaa acctgctttg     5820

gatatatggc catatccttc tcctagaccg acctttggca tcacttggag gtatagactt     5880

cagacagtaa agtccttagc tggagtgagc ctgatgttac ggttactgtg ggcaagtttg     5940

agatgggatg atatggcggc caaggctcct ccaggaggag ggactacacg gacagaaaca     6000

tccgaaactg aaatcacaac aacagaaata attaagagga gagatgttgg tccttatggc     6060

attcgatctg aatattgtat caggaaaatc atttgtccca ttggagttcc agaaacacca     6120

aaagaaacgc ctacacctca gaggaaaggc cttcgatcaa gtgcactgcg gccaaagaga     6180

ccagaaacgc ccaagcaaac tggccctgtt attattgaaa cctgggtagc agaagaagaa     6240

ctggaattgt gggagatcag ggcatttgct gagagagtgg agaaagaaaa ggcacaagca     6300

gttgagcaac aggctaagaa acgactggag cagcagaagc cgacagtgat tgcaacttcc     6360

actacttccc caacaagcag tacaaccagc accatctctc cagcacagaa ggttatggtg     6420

gcccccataa gtggctcagt tacaactgga accaaaatgg tactaactac taaagttgga     6480

tctccagcta cagtaacatt ccaacaaaac aagaactttc atcaaacctt tgctacatgg     6540

gttaagcaag gccagtcaaa ttcaggcgtt gttcaagtac agcagaaagt cctgggtatc     6600

attccatcaa gtacaggtac cagtcagcaa acctttactt cattccagcc caggacagca     6660

acagtcacaa ttaggcccaa tacctcaggc tctggaggaa ccacaagcaa ttcacaagta     6720

atcacagggc ctcagattcg ccctggtatg accgtgatta gaacaccact ccaacagtca     6780

acactaggaa aggcaattat tcgaacacct gtgatggtac agccaggtgc tcctcagcaa     6840

gtgatgactc aaatcatcag ggggcagcct gtctccactg cagtctccgc ccctaacacg     6900

gtttcctcaa cacctgggca gaaaagctta acttcagcaa cgtccacttc aaatatacag     6960

tcttcagcct cacaaccccc tcgcccccaa caaggacaag tgaagctcac catggctcaa     7020

cttactcagt taacacaggg ccacggtggc aatcaaggtt tgacagtagt aattcaagga     7080

caaggtcaaa ctactggaca gttgcagttg atacctcaag gggtgactgt actcccaggc     7140

ccaggccagc agctaatgca agctgcaatg ccaaatggta ctgttcagcg attcctcttt     7200

accccattgg caacaacagc caccacagcc agcaccacca ccaccactgt ttccacgaca     7260

gcagcaggta caggtgaaca aaggcagagt aaactgtcac cccagatgca ggtacatcaa     7320

gacaaaaccc tgccaccagc tcagtcatca agtgtgggtc cagcagaagc ccagccacag     7380

actgctcagc cttcagctca gccccagccc caaacccagc cccagtcccc agctcagcct     7440

gaagttcaga ctcagcctga agttcagacc caaacaactg tttcatccca tgtcccttct     7500

gaagcacaac ccacccacgc acagtcatcc aagccccaag ttgcagcaca gtctcagcct     7560

caaagtaatg tccaaggaca gtctcctgtt cgtgtccaaa gtccatcaca gactcgaata     7620

cgtccatcaa ctccatccca actgtctcct ggacaacaat cccaggttca gactacaacc     7680

tcacaaccga ttccaattca accacataca tctcttcaga taccttccca aggccagcca     7740

cagtcacaac cccaggtggt gatgaagcat aatgctgtaa tagaacattt aaaacagaaa     7800

aagagcatga ctccagctga aagagaagag aatcaaagaa tgattgtctg taaccaggtg     7860

atgaagtata ttttggataa gatagataaa gaagaaaaac aggcagcaaa aaaacggaag     7920

cgtgaagaga gtgtggagca gaaacgtagc aagcagaatg ccactaagct gtcagctctg     7980

ctcttcaagc acaaagagca gctcagagcc gagatcctga agaagagagc actcctggac     8040

aaggatctgc aaattgaagt gcaggaagag ctgaagagag acctgaaaat taagaaagaa     8100

aaagacctga tgcagttggc tcaggccaca gcagtagctg caccctgccc cccagtgaca     8160

ccagctcctc cagcccctcc agcccctcca ccttcacctc cccctccacc tgctgtgcaa     8220

cacacaggcc ttctgtccac gcccacctta cctgctgctt cccagaagag gaagcgggaa     8280

gaggaaaaag actccagctc aaagtccaag aaaaagaaaa tgatctctac tacctcaaag     8340

gaaactaaga aggacacaaa gctttactgt atctgtaaaa cgccttatga tgaatctaaa     8400

ttttatattg gctgtgatcg gtgtcagaat tggtaccatg ggcgctgcgt tggcatcttg     8460

caaagtgagg cagagctcat tgatgagtat gtctgtccac agtgccagtc aacagaggat     8520

gccatgacag tgctcacgcc actaacagag aaggattatg aggggttgaa gagggtgctc     8580

cgttccttac aggcccataa gatggcctgg cctttccttg aaccagtaga ccctaatgat     8640

gcaccagatt attatggtgt tattaaggaa cctatggacc ttgccaccat ggaagaaaga     8700

gtacaaagac gatattatga aaagctgacg gaatttgtgg cagatatgac caaaattttt     8760

gataactgtc gttactacaa tccaagtgac tccccatttt accagtgtgc agaagttctc     8820

gaatcattct ttgtacagaa attgaaaggc ttcaaagcta gcaggtctca taacaacaaa     8880

ctgcagtcta cagcttctta aagttcagcg tgttaaccta acataaaaca cagcaagaat     8940

ctggttgtct gaactatttt aaattaagga gccagatgtt tttagtcagg ctatcctgac     9000

aagacttgac ctaaacttcg tttttattgg tcataacagt ccaattatat tcttggccaa     9060

ttttgtccaa cggacaagaa aaaagcaaag tcaacgacac cattatcttg tcaagatcag     9120

atggttttac tattgtggca gaagcgagaa aactttgttt attgaaaaaa aaagaaaaag     9180

aaagcaagaa aaaaagatac tatggggtca agtgtaactc catggaaatg ccacgtctgc     9240

tcttcagtga agaagctggt ttagagtctc acagaaaact tttgactgta tttatttatt     9300

gttgcaaaaa agacgctttt ttattgctgc cctcatttgt cagctaatta ttttttctta     9360

taaaatccag ccccggttac atataatcat ctgtatctta tcatgattcc tgtaggtaaa     9420

agtacaagac gacctctaga tgtcttttct ttctatgaaa ggagctgcta tgtacacatg     9480

tgcacacaca cacaactggg aatcaacaat gagtttattg ttcatggtag attaaaatta     9540

agcttgcata aaggttgggc taagtggtcc tggactacag actctgttgc cttgaatata     9600

acagtacaat ttgtcaatta ctctgcacca ggctaaaatg agtaaaatct atttgaaggt     9660

atcttgtttg taaacatttg tcagattcta atttttttct tttgtattaa aattcaacta     9720

tggatgtata tgaaacaaaa taaatggaga taatttttct cccaca                    9766


<210> 1111
<211> 3121
<212> DNA
<213> Homo sapiens

<400> 1111
atgaacttcc aggcgggcgg ggggcagagc ccgcagcagc agcagcagct ggccggcggg       60

cccccccagc agttcgcgct ctccaactcc gcggccatcc gggccgagat ccagcgcttc      120

gagtccgtgc atcccaatat ctacgccatc tacgacctga tcgagcgcat cgaggatttg      180

gcgctgcaga accagatccg ggagcacgtc atctccatcg aggactcgtt tgtgaacagc      240

caggagtgga cgctgagccg ctccgtaccg gagcttaaag tgggcatagt ggggaacctg      300

tctagcggga agtcagccct ggtgcaccgc tatctgacgg ggacctatgt ccaggaggag      360

tcccctgaag gggggcggtt taagaaggag attgtggtgg atggccagag ttacctgctg      420

ctgatccgag atgaaggagg cccccctgag ctccagtttg ctgcctgggt ggatgcagtg      480

gtgtttgtgt tcagcctgga ggatgaaatc agtttccaga cggtgtacaa ctacttcctg      540

cgtctctgca gcttccgcaa cgccagcgag gtgcccatgg tgcttgtggg cacgcaggat      600

gccatcagcg ctgcgaatcc ccgggttatc gacgacagca gagcccgcaa gctctccaca      660

gatctgaagc ggtgcaccta ctatgagacg tgcgcgacct acgggctcaa tgtggagcgt      720

gtcttccagg acgtggccca gaaggtagtg gccttgcgaa agaagcagca actggccatc      780

gggccctgca agtcactgcc caactcgccc agccactcgg ccgtgtccgc cgcctccatc      840

ccggccgtgc acatcaacca ggccacgaat ggcggcggca gcgccttcag cgactactcg      900

tcctcagtcc cctccacccc cagcatcagc cagcgggagc tgcgcatcga gaccatcgct      960

gcctcctcca cccccacacc catccgaaag cagtccaagc ggcgctccaa catcttcacg     1020

tctcggaagg gtgctgacct ggaccgggag aagaaggctg ccgagtgcaa ggtggacagc     1080

atcgggagcg gccgcgccat ccccatcaag caggggatcc tgctaaagcg gagcggcaag     1140

tccctgaaca aggagtggaa gaagaagtat gtgacgctct gtgacaacgg gctgctcacc     1200

tatcacccca gcctgcatga ttacatgcag aacatccacg gcaaggagat tgacctgctg     1260

cggacaacgg tgaaagtgcc agggaagcgc ctgccccgag ccacacctgc cacagccccg     1320

ggcaccagcc cccgtgccaa cgggctgtcc gtggagcgga gtaacacaca gctgggtggg     1380

ggcacaggtg ccccccactc ggccagcagc gcatccctgc actctgagcg ccccctcagc     1440

agctcggcct gggctggccc gcgccctgag gggctgcacc agcgctcctg ctccgtttcc     1500

agcgccgacc agtggagtga ggccaccact tccctgcccc caggcatgca gcaccctgcc     1560

agtggcccag ctgaggtact cagttccagc cccaagctgg atcctccccc atctccccac     1620

tccaaccgga agaagcaccg gaggaaaaag agcaccggga ccccccgacc agacggcccc     1680

agcagtgcta ctgaagaggc agaggagtcg tttgaatttg tggtggtgtc cctcactggg     1740

cagacgtggc acttcgaggc ttcaacggcg gaggagcggg agctgtgggt tcagagtgtg     1800

caggcccaga tccttgccag cctgcaaggc tgccgcagtg ccaaggacaa gactcgactg     1860

gggaaccaga acgcagctct ggctgtgcag gccgtccgca ccgtccgcgg caacagcttt     1920

tgtatcgact gcgatgcacc caatccagac tgggccagcc tgaacctggg tgccctgatg     1980

tgcattgagt gctcaggcat ccaccgacac ctgggggctc acctgtcccg ggtgcgctcc     2040

cttgacctcg atgactggcc gcctgagctg ctggctgtca tgactgccat gggcaatgcc     2100

ctcgccaaca gcgtctggga gggggccttg ggtggctact ccaagccagg gcctgatgcc     2160

tgcagagagg agaaggaacg ctggatacgg gccaagtatg aacagaagct cttcctggcc     2220

ccactgccaa gctcagatgt gccactgggg cagcagctgc tccgggccgt ggtggaagat     2280

gacctgcggc tgttggtgat gctcctggca catggctcca aagaggaggt gaatgagacc     2340

tatggggacg gggacgggcg gacggctcta catctctcca gtgccatggc caacgttgtc     2400

ttcacgcagc tgctcatctg gtacggggtg gacgtgagga gccgggacgc ccggggcctg     2460

actccactgg catatgctcg ccgggccggc agccaggagt gtgcagacat cttgatccag     2520

catggctgcc ctggggaggg ctgtggctta gcgcctaccc ccaacagaga gcctgccaat     2580

ggcaccaacc cctctgctga gctgcaccgt agtcctagcc tcctataagg cccaggaaga     2640

gggcagaggg gccagaagga ctccatggcc caaagaccct cctccctgca ggcactgtgg     2700

gaacagacac agagatggag aagcagggac atgctgagag gacgaagcca aggaaattag     2760

ggaggagagt caaagggatc aaggagagtt ggggatttga gctgcagcag agagggatga     2820

gggatttagc cctctgccct aaggtgccat tgaaaaggga caggaccctt cggaggtgcc     2880

tgtgaggaga ggggagcagg acctctccct cctccagatc cctgcctcct agtgccagcc     2940

cctcacacgc cttcatcctg aaacaggaag aggacggcac caagttgggg gtgctggatg     3000

aaagagacga ggggtgatct gtgagtccca tgtaaacttt gtacattgga atatttatgt     3060

ttgtgtacat atttgatgtg tgtgtgtatg atgagccaat aaaccagact gtgtgcgtgg     3120

c                                                                     3121


<210> 1112
<211> 2157
<212> DNA
<213> Homo sapiens

<400> 1112
gctgggcctg gaacacggag cagtggctgc cctgcgagga ggtcctagag cagctccagc       60

aggatggcgg ctccagcgtc tctaaggcct gcagggggtc cagccccatg gggggcgccc      120

taggcctccg acagctcccc atctgtgctc ctgcctgccg gccatcctca ggccactcgc      180

catgggcggc tgcttctcca aacccaaacc agtggagctc aagatcgagg tggtgctgcc      240

tgagaaggag cgaggcaagg aggagctgtc ggccagtggg aagggcagcc cccgggccta      300

ccagggcaat ggcacggccc gccacttcca cacggaggag cgcctgtcca cccctcaccc      360

ctaccccagc cctcaggatt gcgtggaggc tgctgtctgc cacgtcaagg acctcgagaa      420

tggccagcgt tctgtcccgt ggtcgggtgc gctgcccctg gcacggcgcc tgcttcaaca      480

tcagcactgg ggacctggag gacttccctg gcctggacag tctacacaag ttccaggtga      540

agattgagaa ggagaaggtg tacgtccggg ccagcaagca ggccctacag ctgcagcgaa      600

ggaccaaggt gatggccaag tgtatctctc caagtgctgg gtacagcagt agcaccaatg      660

tgctcattgt gggtgcaggt gcagctggcc tggtgtgtgc agagacactg cggcaggagg      720

gcttctccga ccggatcgtc ctgtgcacgc tagaccggca ccttccctac gaccgtccca      780

agctcagcaa gtccctggac acacagcctg agcagctggc cctgaggccc aaggagtttt      840

tccgagccta tggcatcgag gtgctcaccg aggctcaggt ggtcacagtg gacgtgagaa      900

ctaagaaggt cgtgttcaag gatggcttca agctggagta cagcaagctg ctgctggcac      960

cagggagcag ccccaagact ctgagctgca aaggcaaaga agtggagaac gtgttcacta     1020

tccggacgcc agaggatgcc aatcgcgtgg tgaggctggc ccgaggccgc aacgtggtcg     1080

tcgtgggagc cggcttcctg gggatggagg tggccgctta cctgacggag aaggcccact     1140

ctgtgtctgt ggtggagctg gaggagacgc ccttcaggag gttcctgggg gagcgcgtgg     1200

gtcgagccct catgaagatg tttgagaaca accgggtgaa gttctacatg cagacggagg     1260

tgtctgagct gcggggccag gagggaaagc tgaaggaggt tgtgctgaag agcagcaagg     1320

tcgtgcgggc tgacgtctgc gtggtgggca ttggtgcagt gcccgccaca ggcttcctga     1380

ggcaaagcgg catcggtttg gattcccgag gcttcatccc tgtcaacaag atgatgcaga     1440

ccaatgtccc aggcgtgttt gcagctggcg atgctgtcac cttccccctt gcctggagga     1500

acaaccgcaa agtgaacatt ccacattggc agatggctca tgctcagggg cgcgtggcag     1560

cccagaacat gttggcgcag gaggcggaga tgagcactgt gccctacctc tggaccgcca     1620

tgtttggcaa gagcctgcgc tacgcgggct acggagaagg cttcgacgac gtcatcatcc     1680

agggggatct ggaggagctg aagtttgtgg ctttttacac taaaggcgac gaggtgatcg     1740

ccgtggccag catgaactac gatcccattg tgtccaaggt cgctgaggtg ctggcctcag     1800

gccgtgccat ccggaagcgg gaggtggaga ctggcgacat gtcctggctt acggggaaag     1860

gatcctgagc tcacatgcag tagacttggg caggcaaagg gggcaccaag ggcacaggcc     1920

aagccttggg ggcaggtgcc aatctccagt cccaggatcc cccagggcag aacctgagcc     1980

ctcccagtgc ttgccttcag ccacctggct cccctcctgg gaggcctctg ctggatccag     2040

aagatgctca accctcaagg cctctgctgc cactgacagc tggcactgga ggcaggacaa     2100

gccctgcctc ttctccctct attgggactg gtcccctgaa gaaccctgca acacgtt        2157


<210> 1113
<211> 3081
<212> DNA
<213> Homo sapiens

<400> 1113
ctccgccgag ctctgccccg gcgagacgag gcgcctccgt cgccaagccg cgccgtcgcg       60

gggctcccgg gagcggccct tagcgacccc gcccgggccc cctcagctta caaaacacta      120

cacagcaaaa taatgatctg ctagactgct aacccgagca tccagcttcc acaatgcctg      180

tgcaggcagc tcaatggaca gaatttctgt cctgtccaat ctgctataat gaatttgatg      240

agaatgtgca caaacccatc agtttaggtt gttcacacac tgtttgcaag acctgcttga      300

ataaacttca tcgaaaagct tgtccttttg accagactgc catcaacaca gatattgatg      360

tacttcctgt caacttcgca cttctccagt tagttggagc ccaggtacca gatcatcagt      420

caattaagtt aagtaatcta ggtgagaata aacactatga ggttgcaaag aaatgcgttg      480

aggatttggc actctactta aaaccactaa gtggaggtaa aggtgtagct agcttgaacc      540

agagtgcact gagccgtcca atgcaaagga aactggtgac acttgtaaac tgtcaactgg      600

tggaggaaga aggtcgtgta agagccatgc gagcagctcg ttcccttgga gaaagaactg      660

taacagaact gatattacag caccagaacc ctcagcagtt gtctgccaat ctatgggccg      720

ctgtcagggc tcgaggatgc cagtttttag ggccagctat gcaagaagag gccttgaagc      780

tggtgttact ggcattagaa gatggttctg ccctctcaag gaaagttctg gtactttttg      840

ttgtgcagag actagaacca agatttcctc aggcatcaaa aacaagtatt ggtcatgttg      900

tgcaactact gtatcgagct tcttgtttta aggttaccaa aagagatgaa gactcttccc      960

taatgcagct gaaggaggaa tttcggagtt atgaagcatt acgcagagaa catgatgccc     1020

aaattgttca tattgccatg gaagcaggac tccgtatttc acctgaacag tggtcctctc     1080

ttttgtatgg tgatttggct cataaatcac acatgcagtc tatcattgat aagctacagt     1140

ctccagagtc atttgcaaag agtgtccagg aattgacaat tgttttgcaa cgaacaggtg     1200

acccagctaa cttaaataga ctgaggcctc atttagagct tcttgcaaac atagacccta     1260

atccagacgc tgtttcacca acttgggagc agctggaaaa tgcaatggta gctgttaaaa     1320

cagtagttca tggccttgtg gacttcatac aaaattatag tagaaaaggc catgagaccc     1380

ctcagcctca gccaaacagc aaatacaaga ctagcatgtg ccgagatttg cgacagcaag     1440

ggggttgtcc acgaggaaca aattgtacat ttgcccattc tcaggaagag cttgaaaagt     1500

gtaacccccg tggactatat cttcattgtt gtctcctttc ctcagtggct agcttgggca     1560

ctgtacataa tgagctctac aagcagcagc attgtgatag agagaagata agtgtgtgtg     1620

cagtgaaaag agcagaaaca tgcttctctt ctcagttttt ttccccactt gaagtgccta     1680

gagaagagga ttaaggagtc ctaaggaaaa aagatgctgt ttgtacccaa tcgaactagt     1740

tctatataca gaatttcaca tcaagataat ttgggagact ccaggaaata cattcagctt     1800

gtccatacct gaaatagagc tttttagcta aaaggggagc ttttgagaaa gttcgactaa     1860

aaaagtcaga gaagaaactg tggtttcatt gccattccac cctcaattag tgcccaggct     1920

gaaaatccat tttcttcttt ctcatacctt caaacagact tcacattctt catctgcagt     1980

acctagttca gaactttatt atattttgcc agacttgtaa tagtagcagt aaaaataata     2040

atagccaaac taggtgtagt ggctcatgcc tgtattccca gcagtttggg aggcaaaggc     2100

aggaggatac cttgagtcca ggagtttgag accagcctgg gcaacatagt gagacctcac     2160

ctctacaaaa aaataaacaa aattggctga gcatagtggc atacgcctgt catcttagct     2220

actcaggagg ctgaggtggg aggattgctt gaactcggga ggtcaggtct gccgtgaact     2280

gagattatac cactgtattc caacccgggc agcagagcaa gactctgtct caaaaatata     2340

aataaataaa aataataaaa taataaatat ataaaatatc actcattcaa aaataataat     2400

aatggcaaaa ttattggtca catttttagt gtttcacatg gtaatccagt tggttttact     2460

gcttcagtgg ctttttatcc agtatcttcc tatatctcaa tctgtctttt ccatttccac     2520

tattttcttt ttaaaatatg tgtgtctcct ttaaattctt aattagttcc tcagtacatc     2580

acagaatctc atcctgattt tatcctctag ctctactctg ccatttgtat actttgtttt     2640

taaggtatat tcaattaatc actgttgatt actatataaa tttcttttac tcttcttttc     2700

acttgtctat attgtttatt ccatattgta ttattttctc tctcctcttt atctggataa     2760

ctatttctaa tcatactcag atattatctt ccctccacag acttccctag gcagtgttaa     2820

ttgcatcctt caccatgctg ccatagcact ccatacatag tagtttaaaa attatggtat     2880

agttagctgg gtgtggtggc aagcacctgt aatcccagct gctcgggagg ctgaggcggg     2940

agaatggctt gaacttggga ggcagaggtt gcagtgagcc gagatggcgc cactatactc     3000

ctgtgtggac gacagagcaa gattccgtct caaaaaaata aatataaata aataaataaa     3060

aattatggta tagttataaa a                                               3081


<210> 1114
<211> 971
<212> DNA
<213> Homo sapiens

<400> 1114
gattagggcc aacatggccg ccgccgccgc ttggagctga agtgccgccg ccgccgggca       60

gccacgggga atccgcccgc atcgccgccc tcgccggccg ggcggccgtg gggcccagag      120

cgccggaggc cagggctggg gcggcaccgc gcagcggcca cggggtcccg ttagagcagc      180

gcccggcggc tatgccgaga gcccggagcg gccggaggag cagaggggcc ggcgggaggg      240

aggaaacctt tctgcgagta cgagccaacc ggcagacccg actgaatgct cggattggga      300

aaatgaaacg gaggaagcaa gatgaagggc aggtatgtcc cctgtgcaac cgccccctgg      360

caggatcgga gcaggagatg agtaggcatg tggagcattg cctttctaag agggaaggct      420

cctgcatggc tgaggatgat gctgtggaca tcgagcatga gaacaacaac cgctttgagg      480

agtatgagtg gtgtggacag aagcggatac gggccaccac tctcctggaa ggtggcttcc      540

gaggctctgg cttcatcatg tgcagcggca aagagaaccc ggacagtgat gctgacttgg      600

atgtggatgg ggatgacact ctggagtatg ggaagccaca atacacagag gctgatgtca      660

tcccctgcac aggcgaggag cctggtgaag ccaaggagag agaggcactt cggggcgcag      720

tcctaaatgg cggccctccc agcacgcgca tcacacctga gttctctaaa tgggccagtg      780

atgagatgcc atccaccagc aatggtgaaa gcagcaagca ggaggccatg cagaagacct      840

gcaagaacag cgacatcgag aaaatcaccg aagattcagc tgtgaccacg tttgaggctc      900

tgaaggctcg ggtcagagaa cttgaacggc agctatctcg tggggaccgt tacaaatgcc      960

tcatctgcat g                                                           971


<210> 1115
<211> 2529
<212> DNA
<213> Homo sapiens

<400> 1115
agcgggcgcc ggacgacctg tggcccaatg gcggcggcgc gcgggcacgc tgggggccgg       60

ccagacgggc cgacttttcc agaagacccg gatagttcct cccggccacg ccgcgccggc      120

tctgggcact cagcatcgtt tccttttcct ccgctggagc agctatggcg gcggtgaaga      180

ccctgaaccc caaggccgag gtggcccgag cgcaggcggc gctggcggtc aacatcagcg      240

cagcgcgggg tctgcaggac gtgctaagga ccaacctggg gcccaagggc accatgaaga      300

tgctcgtttc tggcgctgga gacatcaaac ttactaaaga cggcaatgtg ctgcttcacg      360

aaatgggcct tcatcctaga ataatcactg aaggatttga agctgcaaag gaaaaggccc      420

ttcagttttt ggaagaagtc aaagtaagca gagagatgga cagggaaaca cttatagatg      480

tggccagaac atctcttcgt actaaagttc atgctgaact tgcagatgtc ttaacagagg      540

ctgtagtgga ctccattttg gccattaaaa agcaagatga acctattgat ctcttcatga      600

ttgagatcat ggagatgaaa cataaatctg aaactgatac aagcttaatc agagggcttg      660

ttttggacca cggagcacgg catcctgata tgaagaaaag ggtggaggat gcatacatcc      720

tcacttgtaa cgtgtcatta gagtatgaga aaacagaagt gaattctggc tttttttaca      780

agagtgcaga agagagagaa aaactcgtga aagctgaaag aaaattcatt gaagataggg      840

ttaaaaaaat aatagaactg aaaaggaaag tctgtggcga ttcagataaa ggatttgttg      900

ttattaatca aaagggaatt gacccctttt ccttagatgc tctttcaaaa gaaggcatag      960

ttgctctgcg cagagctaaa aggagaaata tggagaggct gactcttgct tgtggtgggg     1020

tagccctgaa ttcttttgac gacctaagtc ctgactgctt gggacatgca ggacttgtat     1080

atgagtatac attgggagaa gagaagttta cctttattga gaaatgtaac aaccctcgtt     1140

ctgtcacatt attgatcaaa ggaccaaata agcacacact cactcagatc aaagatgcag     1200

tgagggacgg cttgagggct gtcaaaaatg ctattgatga tggctgtgtg gttccaggtg     1260

ctggtgccgt ggaagtggca atggcagaag ccctgattaa acataagccc agtgtaaagg     1320

gcagggcaca gcttggagtc caagcatttg ctgatgcatt gctcattatt cccaaggttc     1380

ttgctcagaa ctctggtttt gaccttcagg aaacattagt taaaattcaa gcagaacatt     1440

cagaatcagg tcagcttgtg ggtgtggacc tgaacacagg tgagccaatg gtggcagcag     1500

aagtaggcgt atgggataac tattgtgtaa agaaacagct tcttcactcc tgcactgtga     1560

ttgccaccaa cattctcttg gttgatgaga tcatgcgagc tggaatgtct tctctgaaag     1620

gttgaattga agcttcctct gtatctgaat cttgaagact gcaaagtgat cctgaggatt     1680

acagctgtgg aatttttgtc caagcttcaa ataattttga aagaaatttt cccatatgaa     1740

aaaaggagag aacactggca tctgttgaaa tttggaagtt ctgaaattat agtattttta     1800

aaaattgcac tgaagtgtat acacataaag caggtctttt atccagtgaa caggatgttt     1860

tgctttagca gcagtgacat aaaattccat gttagataag catatgttac ttaccttgtt     1920

attaaatatt tcttgaaaag caaattttaa tggtttaatt ttatgtggac gtatgttaaa     1980

ttatccaact accctattgt taagcatttg gttttaaaat ttttatgcta atataaatgc     2040

tcaagtaatt taaaatattg aaagcatccc tgttggtata aatttctgag taaatgcatt     2100

ggatcagttg gactttgaac gcctttgaaa tggctttgct aaaatgctcc cgccacaaag     2160

ttgtaggaaa tgggaagagg agtcaactag aggcaaggga gttgagagag ctgcaactgt     2220

aaagggcaag aacaggcaga ggtaaaaaga tgatggaagg tgtggtgact aagggccacg     2280

gttattgggt gaaatttgag attgtaggcc aactgtattt tcaagcttct gaacttaggc     2340

aaaatattca tcgcaaagtc tctagcgtca tatttttctc acccaaatta cgtttccacg     2400

agattattta tatatagttg gtctatctct gcagtccttg aaggtgaagt tgtgtgttac     2460

taggctgtgt tttgggatgt cagcagtggc ctgaagtgag ttgtgcaata aatgttaagt     2520

tgaaacctc                                                             2529


<210> 1116
<211> 1733
<212> DNA
<213> Homo sapiens

<400> 1116
tggctttgct cctctttctg ggaaggggtt gcccggctgt gctgccacca tgtcttttcg       60

actttctggt ggatccagga ggatctgctc gcgaactggg tctggtaggc tgtccggtgg      120

aggaacaggc ttcgtggctg ggaatgtgtg tgttggatcg ggagcaagaa gcagcttttc      180

ttgtactctt gagggcatct cttctggagg aagcttctgc aatagcggtg gagggttggg      240

aagtggtgcc tgtgctggtt ttcttggcaa tgagcacagc ctcctctctg ggaatgaaaa      300

ggtgaccatg cagaatctca acgaccgcct ggcatcctac ctggaccatg tgcatgctct      360

agaggaggcc aacgcagacc tggagcagaa gatcaagggc tggtacgaga aatgtgagcc      420

tggctcttcc cgggaacacg atcatgacta tagcagatac ttctcagtca tagaagatct      480

taaaaggcag attatttctg cgaccatctg caatgccagc attgttctac aaaatgacaa      540

tgccagactg accgctgatg acttcaggct gaagtatgaa aatgagctgg ctctgcacca      600

cagtgttgag gccgacacca gtggtcttcg cagagtgttg gatgaactga ccctttgtac      660

aaccgacctg gagatacagt gtgagaccct cagtgaggaa ttgacctacc tcaaaaaaag      720

tcatgaggag gaaatggaag tcttgcaata tacagctggg gggaacgtga acgtggagat      780

gaatgcaacc ccaggagtgg acctaactgt cctgttgaac aacatgaggg ctgagtatga      840

ggacttggct gagcagaacc gcaaagatgc tgaagcctgg ttcaacgaga ggagtgcaac      900

gctgcaacaa cagatttccg atcatgaggg agcagccaca gcagccagaa atgagctgac      960

cgaattaaaa cgcaatctgc aaaccctgga aatagaactt cagtccctca tggctgtgaa     1020

acattcctat gaatgctcct tggctgagac tgaaggaaat tactgcaatc aactccagca     1080

aattcaggat cagatagggg tgatggagga acaactgcaa cagattcgaa cagaaacaga     1140

aggccagaag ctggagtatg aacagcttct tgatgtaaaa atatttttag aaaaagaaat     1200

tgacatttat tgcaacttac tagatggaga agaaagaaaa agcaaatcca catgttacaa     1260

atcaaaagga tacaggcctg tgaattctgg aaatcaagcc aaagactcaa cagaagaaac     1320

tattgttaaa acagtggttg aggaactgga tcaaattggc aatctccttt cactgagagt     1380

ccactcagtt gaagaaaagt cctctaaaat aagcaacatt acagtagagc aacgagtacc     1440

ttctaaagca ccataatgag gaaaaagtta tttggaaaga aagaaagaaa gagagagaga     1500

gagaaagaaa gaaagaaagg ctgcctttgc aaaaatccta ctggtcaaat aacctaagga     1560

aattattcat ttctgttctt aaaagggcta gaatttgttc tccttctctt ccttttctca     1620

tgttctatgc atgtaatcct tttccagagt agaaaaatcc tgctctgtcc ctaatttttg     1680

tttttatttt gggggccttt tttgacattt cattaaaaat tcttctattg caa            1733


<210> 1117
<211> 4290
<212> DNA
<213> Homo sapiens

<400> 1117
ttccggcttc cccgccccgc cccgtccccg ggcgtctcca ttttggtctc aggtgtggac       60

tcggcaagaa ccagcgcaag agggaagcag agttatagct accccggccg cggagccggc      120

tcactgcact acccccgccc ccttctttcc tccagacgcc gaagtcgcgg gcgctcatgg      180

cgggcctgga ggtactgttc gcatcggcag cgccggccat cacctgcagg caggacgcgc      240

tcgtctgctt cttgcattgg gaagtggtga cacacggtta cttcggcttg ggtgtcggtg      300

accagccggg tcccaatgat aagaagtcag aactgctgcc agctgggtgg aacaacaata      360

aagacctgta tgtcctccgg tatgagtata aggatgggtc cagaaagctc cttgtgaaag      420

ccatcaccgt ggagagcagc atgatcctca atgtgctgga atatggctca cagcaagtgg      480

cagacttgac cctgaacttg gatgattata tcgatgcaga acacctgggt gacttccaca      540

ggacctacaa gaacagtgag gagcttcggt ctcgtattgt gtctggaatc atcacaccta      600

tccatgagca gtgggaaaag gctaatgtaa gcagtcccca ccgggagttc ccccctgcta      660

ccgccagaga ggtggaccca ctccggattc ctccacacca cccacacacc agtcggcagc      720

ctccctggtg tgatcccctg ggcccgtttg ttgtcggggg agaagactta gacccttttg      780

ggcctcggag aggtggcatg attgtggatc ccctgagatc tggcttccca agagcactta      840

ttgacccttc ctcaggcctc ccgaaccgac ttcctccagg cgctgtgccc ccaggagctc      900

gctttgaccc ctttggaccc attgggacca gcccacccgg acctaaccca gaccatctcc      960

ccccgccggg ctacgatgac atgtacctgt gaaggcctca agaatgtaac atcccaggct     1020

tccctccatt ctcctggagc tgccaccgct gtccccatca gcaaccatgt tcttgcaggc     1080

tgggggcaag ggattctgct catgtgtttg cagaccggct gggatagcct ccccacccct     1140

tatcagagcc aagacacctg ctgcagctct ccacctagct gcagatagct cccaaagaga     1200

aatcagtgtg tctctttcac catcagctcc tcccctttca ccaccagctc ctctccactt     1260

cccaagggag actccggcaa ccttcagcaa catatatcct cgaccagatg cagtgctata     1320

agaacagaac gcattttgga tgttattatt aagaaccaaa tgtcaataca gaattcatgt     1380

tgccggtttc ccacttttct ttttacatta atgcatagct gcttccattt atgagacttt     1440

agagtttgag tttctgtagg gctgaatgac tctttttcct gcccagggcc cattcttgct     1500

tctcaggcac cttccgttta ttaattgcca ttgctcctga catcactaag atgggtcccc     1560

ttctggctgc atgaatggaa atgagtgact ggaaatccca taggccacaa gaatgacttt     1620

cacaagggca ggaacattgt ggaaagactg catcattctg atgaggcaaa atcctccagc     1680

tattcctgtc tgggccagtt ttgtaggtcc atctgtgcat gggcagcagt agtcaaaaag     1740

ccaaggaaaa aacagagcag acctgaaggc taatcttatt tttgccacta acttagtgaa     1800

tgaccctaag caagttcctt ctcctcttag ggccttgtgc caagcctatg aaattggagg     1860

tggctttcct gctctaaagc attttgatgt ctcattctgt gtttggtaac ccctataaac     1920

tggggcagag gaaaagaatg atggttcaag gccatacttc ccttgaacct tgtgtggttc     1980

ttgcctaact ctgtggtttt tggaccccat ggggcccaga cagagcacag gagcatgggc     2040

tgcctctgag tgtggtgttg aacttcggga ggagcaggga gccctgcacc ttgtgtcctg     2100

gcccacctga cctttggtgt tctccggatc cttttcagcc cgaggcctga cagacgcggg     2160

cagtgatgag ccctgttctg gagtggaaag agcacgatag agcaccaggc taagaggcac     2220

gagatcaagg cggtagtcac ttccgctctg cagctagcat ttcaaccata tgtggatcct     2280

ttcatttctc agctccctgg attccttccc ctaaattagg acctattatt tacctgtagg     2340

taagcaagct actgtagctc ttctgaggta tctgccaggc tgttttctgt agcctcagat     2400

tgcctatctg cttagcctga gaacaggtag atgaaaacta aactgatgcc taggcccagg     2460

gtcagtctca gatggaagct gggcctgggt ggggaggcta gcatgcgtgg ctccctgggt     2520

atttctgtca gtccccatgg caagcagtga tttagtaaaa caccccagag tcagggaagc     2580

caaccacctt gaaaccttta gaacatctct gctttggaga aagacccaga gatcaggcag     2640

aggtgcagat tcaatcatta ctcataacct ttgagagatg gcaaatggga ggagtgttag     2700

tctttgtttt ggaattggac cattcttgca accaaaagga cttagagcag tttgctcata     2760

aagacatcct ttattataaa aggaagtatt taaaggatga tagagaccat cagatagaag     2820

cagggaaggt agataacttt taggaccttg atgtgaggaa aagataaaat ttaaacaata     2880

aatttgccac ttagattttc tagcagcaaa gtccgaaaag atagttatat acaaaattct     2940

gttttctgaa aacaaaattg tgattcacct tcagaattgg ccattttttt tgtgagtttc     3000

cttgcatcaa ggacactgag aaacacagtc attgtcttag gtgttctatg ggaggaagtg     3060

aatagagcct ttaggaactt cctggtcaag cttatggtgc ttattttgat ctgggccact     3120

tccctccttc cagtcatgag taatcatcaa ggagcaagtt ggagtgtttc aggtgtatat     3180

tttgtagaac ccaaaagatt ggagccttaa caataaacat cagcactaag tgacctgttc     3240

ctcctttttt aaatagcagc tttattgaga tataatttac atacccataa tttacatacc     3300

tgtttaaagt atacaattca gtggatttag tatgttcaca gtgttgcaca tccaccacca     3360

tttctaattc ctgaacattt tcaccacctc aaaaagaaac cacacaccca ttggcatgac     3420

tccccattcc cttgctccca gccccaggca accactaaca tctgtctcta aagatttttt     3480

ttttttttct ggacagttct cataagtgga atcactcagt attatggcct tttgtgtctg     3540

gcttctttca tttcatgtga tgttttcaag attcattcat gctgtagcat gtatccatgg     3600

tatggatata tcacattttg cttatccttt tatcagttga tggacagttg ggttgtttct     3660

acaaaaaggc tattatgagt aatgcagcca agaacatttg tgtaccagtt tttgagtttt     3720

cagttgtttg agtttcagat gttttcagtt catttgggta tataccaagg agtggaattg     3780

ctggttcaca tggtagctct atattctact ttgtgaggaa ttgtcagact gttttccacg     3840

gaagctgcac cattttacat ttccactggt aatttatgag ggttccagtt tccccacatc     3900

ttcaccaact cttgttattt ttcatgctta tggccatcct agttagcgtg aagtagcatc     3960

tcattgtggt cttctcttcc attttttaaa aaagaatttt gacctacacc aagcaaggca     4020

gagaccagag tcagtccccc ttggggagca atctgtggtt ttgataatca ccaccttggg     4080

atgaacatgg ctggtgagct gcagagcagt tgatttgact tttggggatg gttctaggct     4140

ggatgtgata cagggcaggt tttgtctcta gagaaagttc tcatgacctt caggtctaat     4200

gagattcaga tcatcacttt ggtttggttt gaaatttctt tgtttatcca gtgaattaca     4260

agtagaataa agatctggtt ctaaattgtc                                      4290


<210> 1118
<211> 753
<212> DNA
<213> Homo sapiens

<400> 1118
atgagtgaga acgccgcacc agacttttat tacgttgcca tggatttcgg aggtcatggg       60

ctctcgtccc attacagccc aggtgtccca tattacctcc agacttttgt gagtgagatc      120

cgaagagttg tggcaggtgg cgtcgtgggc ggaatgtttt tctgtacctt ccccgagatg      180

gtggataaac ttatcttgct ggacacgccg ctctttctcc tggaatcaga tgaaatggag      240

aacttgctga cctacaagcg gagagccata gagcacgtgc tgcaggtaga ggcctcccag      300

gagccctcgc acgtgttcag cctgaagcag ctgctgcaga ggttactgaa gagcaatagc      360

cacttgagtg aggagtgcgg ggagcttctc ctgcaaagag gaaccacgaa ggtggccaca      420

ggtctggttc tgaacagaga ccagaggctc gcctgggcag agaacagcat tgacttcatc      480

agcagggagc tgtgtgcgca ttccatcagg aagctgcagg cccatgtcct gttgatcaaa      540

gcagtccacg gatattttga ttcaagacag aattactctg agaaggagtc cctgtcgttc      600

atgatagaca cgatgaaatc caccctcaaa gagcagttcc agtttgtgga agtcccaggc      660

aatcactgtg tccacatgag cgaaccccag cacgtggcca gtatcatcag ctccttctta      720

cagtgcacac acatgctccc agcccagctg tag                                   753


<210> 1119
<211> 701
<212> DNA
<213> Homo sapiens

<400> 1119
gaggtaaagg ccgcgcttgg gtgtccctgg gtggtcgggt ccccgagttg ggaggggcgg       60

aaggctgaac ctccagcttg agccggacaa gccgattccc agcgttgaga gggtagagat      120

gaactgtgtg tgaggccaaa ctggatcggt caacatggtc ttccccctcc ccactcccca      180

ggagcccatc atggcgacgc cccctaagcg gcgggcggtg gaggccacgg gggagaaagt      240

gctgcgctac gagaccttca tcagtgacgt gctgcagcgg gacttgcgaa aggtgctgga      300

ccatcgagac aaggtatatg agcagctggc caaatacctt caactgagaa atgtcattga      360

gcgactccag gaagctaagc actcggagtt atatatgcag gtggatttgg gctgtaactt      420

cttcgttgac acagtggtcc cagatacttc acgcatctat gtggccctgg gatatggttt      480

tttcctggag ttgacactgg cagaagctct caagttcatt gatcgtaaga gctctctcct      540

cacagagctc agcaacagcc tcaccaagga ctccatgaat atcaaagccc atatccacat      600

gttgctagag gggcttagag aactacaagg cctgcagaat ttcccagaga agcctcacca      660

ttgacttctt ccccccatcc tcagacatta aagagcctga a                          701


<210> 1120
<211> 4114
<212> DNA
<213> Homo sapiens

<400> 1120
aggcaaagcc atgactacag tagtggtaca tgtggactcc aaagctgagc tcactaccct       60

gctggagcag tgggaaaagg aacatggcag tgggcaggac atggtaccta tccttaccag      120

gatgtctcaa ttgattgaaa aagaaactga agagtatcgt aaaggggatc cagacccatt      180

tgatgatcga catcctggtc gagctgatcc agagtgtatg ctgggccact tgctgagaat      240

actcttcaag aatgatgatt tcatgaatgc actggtgaat gcatatgtga tgacaagccg      300

agagccccct ttaaacactg cagcttgcag actcctatta gacatcatgc cagggctgga      360

aactgctgtc gtctttcaag aaaaggaggg aattgtcgag aatcttttca aatgggcccg      420

agaggccgat caaccattga ggacatattc tactggactg ttaggaggtg ctatggaaaa      480

tcaagacatt gctgccaact atagagatga aaattcacag ctggtggcaa tagtgcttcg      540

aagactgagg gagctacagc tacaggaagt ggctttgcgg caggaaaaca agcgtcccag      600

tccacggaag ctctcttctg aacccctttt gcctctggat gaggaggctg tggatatgga      660

ctatggtgac atggctgtag atgatgctga aattcagaag tcagcacttc agattatcat      720

caattgtgtg tgtggcccag ataaccgaat atccagtatt ggtaaattta tctctggtac      780

tcctcggaga aagctgcctc agaaccctaa aagcagtgag cacaccctgg ccaagatgtg      840

gaatgtggtt cagtccaaca acggcatcaa ggtgctcctg tccttactgt ccattaagat      900

gcccatcaca gatgcagacc aaatccgggc cctggcctgc aaagccctag tgggcctgtc      960

tcgcagtagc actgtccggc agatcatcag taaactgccc cttttcagca gctgccagat     1020

ccagcagctg atgaaggagc ctgtgctgca ggacaagcgc agtgaccatg tcaagttctg     1080

caagtatgct gctgaactca ttgaacgggt gtcaggaaaa ccacttctca ttggcactga     1140

tgtttcccta gcacgactgc agaaagcaga tgttgttgcc cagtcaagga tctccttccc     1200

tgagaaagag ctgcttttgt tgatacgaaa ccatcttatt tctaaagggc ttggagaaac     1260

agcaaccgtg ctgacaaaag aggctgacct gcccatgact gctgcctccc attcttctgc     1320

ctttacccca gtcactgctg ctgcttctcc tgtctctcta ccccgaaccc ctcgtatcgc     1380

taatggcatt gcaactcgtc tgggcagcca tgctgctgtg ggtgcctctg cgccttctgc     1440

ccctactgct catcctcagc cacggccccc ccagggtccg ctagctctgc ccggcccatc     1500

ttatgcaggc aactcccctt tgattggtag aatcagtttt atcagagaga ggccatcacc     1560

ctgcaatggc aggaaaatca gagtgttgcg gcagaagtcg gaccatggtg cctacagcca     1620

aagcccagcc ataaaaaaac agctggacag acatcttcct tccccaccta cgctggacag     1680

tataatcaca gagtatctta gagaacaaca tgctcgctgc aagaatccag ttgccacctg     1740

cccacctttc tccctcttta ctcctcacca atgtcctgag ccaaaacaga ggcggcaagc     1800

gccaataaac tttacgtcaa ggctaaaccg cagggcatca tttccaaagt atggaggggt     1860

ggatggcgga tgctttgata ggcaccttat ctttagcaga ttccgtccta tttcagtgtt     1920

ccgggaagcc aatgaagatg agagtggctt cacctgctgt gcattctcag cacgggagcg     1980

gttcctgatg cttggcacct gcacagggca gctgaagctc tataatgtgt ttagtggaca     2040

ggaggaggcc agctataact gtcacaactc agccatcaca catcttgaac cttccaggga     2100

tgggtccttg ctgctgacat ctgctacttg gagccagcct ttgtctgcac tttggggaat     2160

gaagtcagta tttgatatga agcattcctt cacagaagat cactatgttg agttcagtaa     2220

gcactcccag gatcgggtca tcggcacaaa aggagacatt gcccacattt atgatattca     2280

gactggcaac aagctgttga ctctgtttaa cccagatctt gccaacaact acaagaggaa     2340

ctgtgccacc tttaatccta cagatgatct tgtcttaaat gatggcgtcc tctgggatgt     2400

ccgctctgca caggccatcc acaagtttga caagttcaat atgaacatca gtggtgtttt     2460

ccatccaaat ggactggagg tgatcattaa tactgagatt tgggaccttc gaacttttca     2520

tcttttgcat actgttcccg ctctggatca gtgtcgcgtg gtgttcaatc acacgggaac     2580

agtgatgtat ggagctatgt tgcaggcaga tgatgaagat gacttaatgg aagagaggat     2640

gaaaagcccc tttgggtcat ccttccgaac atttaatgca actgactaca aacctatagc     2700

aaccattgat gtgaaacgga acatctttga cctgtgtaca gacaccaaag actgctatct     2760

tgctgtcatt gagaatcaag gcagcatgga tgccctgaac atggacacag tatgcaggct     2820

gtatgaagtg ggcaggcagc gtctggcaga ggatgaggat gaagaggagg accaggaaga     2880

ggaagaacag gaggaagaag atgatgatga agatgatgat gacaccgatg atttagatga     2940

gcttgacact gaccagttgc tggaggcgga gttggaggag gacgacaata atgagaacgc     3000

aggggaagat ggggacaatg acttctctcc ctctgatgag gagctagcaa accttctaga     3060

ggagggagag gacggggagg atgaagactc tgatgcagat gaggaggtgg aactgatcct     3120

gggggacact gacagctctg acaactctga tttggaagat gacatcatct tatctctgaa     3180

tgagtgagga gccatcactg cttggaagag attcttggca ggcgagaaac tgagtcaaat     3240

gaattcagaa catattccct tctctttctc ccagggctgt ctgtctttta aggagctgca     3300

tgccctgcat tcagaagatt atggcttaga gagcctcatt ggcacccgag ggtccttcca     3360

gaatcaataa ccaccacaaa aatgacaaca gggactaggc cctactctgc accccccaca     3420

tccacccccc accatttcct aggatggaca tatctttcaa ggggaaaaaa aaaccatgtc     3480

tctggggtat ttcacaatat attttctttg tatagtgttc tttacttaaa gaacaagaaa     3540

tagtttttta taaaacttta aaaaggaaaa aaaaacaggc atttataact gagggtatga     3600

acttatatcc accaggtctc ttgtccctgc acttcatttt ctttggaaga aaatgatgtc     3660

taaagaacaa tatagaggca tttttacata cgtatttaaa tgaaaaggaa aatcgtggtt     3720

tcttaaattg ataaggatta agaatatttt attataaata taatatatga ttttttaacc     3780

tgttttgttg cctcatatgc tgtcaggtta atttgttttc cttcgtgcca gaggtgggga     3840

ggaaggcact ctgtctgctg ggtaaatgcc taaattcact caccttcatg gtttgggggc     3900

agcatggtca ttgtggatat tggttttgtg gagttgaggg aacttaggat ataagttcac     3960

tccctctatt tttctttgtg attcagtttt tcaaaaatct ttttttcttc cctttctccc     4020

cattgtggaa attacaaatc aaaggccttt ttctttaatg taaagtgtat ttatttaaaa     4080

aaaatacaaa ataaactaca agtctgtctt tgtt                                 4114


<210> 1121
<211> 3610
<212> DNA
<213> Homo sapiens

<400> 1121
ctgcagggta tctggcctag gccccgcccc tccccgccca gcgccccgcc cctgcaacgt       60

gtaggcctcg gctccaacga ggccccatgg ctccgtcccc gccccatcgc cccgcccctc      120

ccgggagccc tgtcttctgc cgtgcgctga gtgtccgcgt cgccctcgcc gcagtcgcgg      180

gcaccccgct cggcgtcggt gcctgaggga ggccgcgatg gcggccgagg ccctggcggc      240

ggaggccgtg gcgtcgcgcc tggagcggca ggaggaggac atccgctggc tgtggtcgga      300

ggtcgagcgc ctgagggacg agcagctgaa cgcgccctac agctgccagg cggaggggcc      360

gtgcctcacg cgggaggtgg cgcagctccg ggccgagaac tgcgacctgc gccaccgcct      420

gtgcagcctg cggctgtgcc tcgccgagga gcggagccgc caggccacgc tggagagcgc      480

ggagctagag gcggcgcagg aggccggcgc acagcctcct cctagtcaaa gccaagacaa      540

ggacatgaaa aagaagaaaa tgaaggaaag cgaggctgac agcgaggtga agcatcaacc      600

aattttcata aaagaaagat tgaagctttt tgaaatactg aagaaagacc atcagctctt      660

acttgccatt tatggaaaaa agggggatac aagcaacatc atcacagtaa gagtggctga      720

tgggcaaaca gtgcaagggg aagtctggaa aacaacgcct taccaagtgg ctgctgaaat      780

tagtcaggaa ctggctgaaa gcacggtaat agccaaagtc aatggtgaac tgtgggacct      840

ggaccgccca ttggaagggg actcttctct agagctgctt acatttgata atgaggaagc      900

tcaagctgtg tactggcact ccagtgctca cattcttggg gaggccatgg agctttacta      960

tggaggccac ctgtgctacg gtccgcccat tgaaaatgga ttttattatg acatgttcat     1020

tgaagacaga gcagtgtcca gcacagaatt gtcagccctg gagaatatat gtaaagccat     1080

cataaaagaa aagcaacctt ttgaaagact agaagtcagc aaggaaatcc tcctggaaat     1140

gtttaagtac aataaattta aatgccgcat tctgaatgag aaagttaaca ctgcaactac     1200

caccgtgtac aggtgcggtc cattaattga cctttgcaaa ggtccacatg taagacacac     1260

tggaaaaatt aaaaccatca aaatttttaa gaattcctca acatattggg agggcaatcc     1320

ggaaatggaa acattgcaga ggatctatgg aatatccttt cctgataaca agatgatgag     1380

agactgggaa aagttccaag aggaagcaaa gaaccgagat cacaggaaga tcgggaagga     1440

acaagaactt ttctttttcc acgatttgag tcctggaagc tgttttttcc ttcccagagg     1500

agccttcatt tataatacgc ttacagattt catacgagag gaatatcaca aacgggactt     1560

cacggaggtg ctctctccca atatgtacaa cagtaaactc tgggaagcct caggccactg     1620

gcagcattac agcgagaaca tgtttacctt tgagattgaa aaggacactt ttgccctcaa     1680

acccatgaat tgtccagggc actgtctaat gtttgcccat cgtccacgat cttggaggga     1740

aatgcctatt agatttgctg attttggagt tctgcataga aatgaactgt cggggactct     1800

cagcggcttg accagagtga ggcgcttcca gcaggacgat gctcacattt tttgcacagt     1860

ggagcagatt gaagaagaaa taaaggggtg tttgcagttt ttgcaatctg tttactcaac     1920

atttggcttc tcctttcaat taaacctgtc aacaaggccg gaaaacttcc taggagagat     1980

tgagatgtgg aatgaggctg agaagcaact gcagaacagc ttgatggact ttggagaacc     2040

gtggaaaatg aacccaggag atggagcatt ttatggccct aaaattgaca taaaaatcaa     2100

ggatgctatt ggcagatacc atcaatgtgc tacaattcag ctggacttcc aactgcctat     2160

tagatttaat ctcacatatg ttagtaagga tggggatgat aagaagagac ctgtgatcat     2220

tcatcgagcc attttgggat cagtggaaag aatgatagcc attctttcag aaaactatgg     2280

cggaaaatgg cctttctggc tatctcctcg tcaggtgatg gtcatccctg tggggccaac     2340

ttgtgaaaaa tatgcacttc aggtatccag tgaatttttt gaagaaggat ttatggctga     2400

cgttgacttg gatcacagtt gtacactaaa taagaaaata cgaaatgcac agctggctca     2460

gtataatttt attttggtgg ttggagaaaa ggaaaagata gataatgctg taaacgtgcg     2520

aacaagagac aacaaaattc atggagagat tttagtaact tctgccattg ataaactgaa     2580

gaatctcagg aagacacgga cactcaatgc tgaggaggcc ttttgaagtc cttccctgat     2640

atttgcttct gtgtaacttt gttttgaccc ttaaaaatgt atttttctta acatgttagt     2700

acttctacga ctttggagcc actgatgggt ccactcatgg cctcagctga gaaaggagac     2760

gatgaacgtg tagctgacat gcacgaagtt taatttactc atgtccacgg gggacgttta     2820

gagggcacgt gggaaatttt ccagcaatca atgccttgag aaacttaaat ggggaaatat     2880

tattcatcga gaaagtgaaa caaaacacta ggaaatgatt atgaaatgtt agtgattttc     2940

aaaagatggg cttcaaataa aagtctgcag agtttttttt aaataggagg gaaaatctta     3000

ttttctaata tgtctcaggt atttttatga cttctactaa aattcacact gaaactttat     3060

cttctaaact ggaatcatta cttaatttta actaaccaac aaccacaaaa gcagcagcta     3120

ctgctaaata ttggattact gacaaaggaa ttcagttttg tggaatctgg tgtttgcact     3180

ataggttaag agttgccatt taaatgtttc ttattcataa ttaggttttg ttccgcttta     3240

gaaaaaaata aattcccaaa tgaattgcat cagtgtttcc agcgtttcag ctgtgggctt     3300

ctaccaccac taagccgctc acctagagtt gttacttttt tgatgggatg acattccatg     3360

gatttatgta ctgaaatgga tttcagattt taaagagagg aatgctctac gtgctcagaa     3420

ctgaattaaa atggcattat gtcaatagag aattcagcta ccaaacaaga agtattgttt     3480

attttgcgat atgctgtgaa attcaaaaga aatgtaagaa ataatctctt ttcaatatac     3540

tgatcattta gttaacttcc tgagggatgt gaacagtgaa acagttggca aacaaaacaa     3600

tatatatcag                                                            3610


<210> 1122
<211> 2492
<212> DNA
<213> Homo sapiens

<400> 1122
gcgggcaggc gactcctgtc ccgggtggag gcggcggagc cggagccggg ggagggggca       60

gcggctgtct cacggaccac ggcggcgccc gcagctcctc accgcagcac ccccactgca      120

ggcccgagga gctttccgga gcttcccaca ctcctgggga gaagacttct tagccagctt      180

gatgtttaaa attcagctgg agcccttaaa acttcgagcg tggacgctga atgggtttgt      240

aaagtttcga aacaaggaga ccagtgctgg tccagtggct gtgatgggaa aagattatta      300

caagattctt gggatcccat cgggggccaa cgaggatgag atcaagaaag cctaccggaa      360

gatggccttg aagtaccacc cagacaagaa taaagaaccc aacgctgagg agaagtttaa      420

ggagattgca gaggcctatg atgtgctaag tgaccccaag aaacggggcc tgtatgacca      480

gtatggggag gaaggcctga agaccggcgg tggcacatca ggtggctcca gtggctcctt      540

tcactacacc tttcatgggg acccccatgc cacctttgcc tccttctttg gtggctccaa      600

ccccttcgat atcttctttg ccagcagccg ctccactcgg cccttcagtg gctttgaccc      660

agatgacatg gatgtggatg aagatgagga cccatttggc gctttcggcc gttttggctt      720

caatgggctg agtaggggtc caaggcgagc cccagaacca ctgtaccctc ggcgcaaggt      780

gcaggacccc ccagtggtgc acgagctgcg ggtgtccctg gaggagatct accatggctc      840

caccaagcgc atgaagatca caaggcgtcg cctcaaccct gatgggcgaa ctgtgcgcac      900

cgaggacaag atcctgcaca tagtcatcaa gcgtggctgg aaggaaggca ccaagatcac      960

cttccccaaa gaaggcgacg ccacacctga caacatccct gctgacatcg tctttgtgct     1020

caaagacaag ccccatgcac acttccgccg agatggcacc aacgtgctct acagtgccct     1080

gatcagcctc aaggaggcgc tgtgtggctg cactgtgaac attcccacta tcgacggccg     1140

agtgatccct ttgccctgca atgatgtcat caagccaggc accgtgaaga gactccgtgg     1200

ggagggcctt cccttcccca aagtgccaac tcagcgagga gacctcattg ttgagttcaa     1260

agttcgcttc ccagacagat taacaccaca gacaagacag atccttaagc agcacctacc     1320

ctgttcctag gctctgcccc agccagtcca gagcctacca cagcaatacc cccaacactc     1380

actccactca atgtgcaccc agcttgatgt ccactggaca ctggcaactt tttctaaaat     1440

gcaaaaaaaa gccactggtt ttcaggaaaa tgttcctgtc cctgacccct tttagagctg     1500

ggctgcctgg ggggagtggg agggaggtgg ggagagctag cccaggccag gggtcaatgt     1560

tcatgtcact agctttcaat ccagtttcca ctgcagtggc tggagagtga cctgagtgct     1620

acttgaagat atgtagagat tccttatcca tgcctgtaca tagcatgtcc tcctcccctc     1680

agctttgcta ataccagtcc cctcccttcc ctttggcttc ctgctgttgg gggtggaaaa     1740

gactagaaag gacattgctt tctcagcccc acccccaggt ccacagtgtc caaggtaatg     1800

gcacacatat tcatgcacaa gaagcactca cctagagctg tctgtgcctc tctgggagaa     1860

aggagagagg ataagaaggg aaagttcaca acctgtgaac agggacttga gcacgagaca     1920

cttttcatct ggagcagggg ggtgagctcc tcagcagcct ccgtaacagc tgccctgcct     1980

acacctgcag agctggaggt tctgtcctcc ctgctgctct caggagtgtt caagggtgga     2040

gggcagggaa tggggcctga ggtattaagg ctaagaggtg ggggacaggg cccatctacc     2100

agccttcatc aggaagggaa agggctttgg ggtcaggtgg cagctattcc ccaccaagag     2160

attcagggtc acaggttttt ccccacacct ctgaactcag ggcctagcca cccccaaact     2220

tccaaatccc acttttgtga tatgtgaagc tactcatttc ttacccttgg aggctgtgtg     2280

gggaatttcc agccctttta tgcctgtgtg atcccacccc acccccatag ttgtataaag     2340

gtcatagtga agaagctggg ggaagactgc ttcagccaga tcctggggtg gggtctttag     2400

gttttctcac tttgacaacc cccgaatgtt tttatagtag tttttttgta tttttttgta     2460

atgacagtat tatgtaaaaa ataaagtatt tt                                   2492


<210> 1123
<211> 1627
<212> DNA
<213> Homo sapiens

<400> 1123
agtgcgttac ttacctcgac tcttagcttg tcggggacgg taaccgggac ccggtgtctg       60

ctcctgtcgc cttcgcctcc taatccctag ccactatgcg tgagtgcatc tccatccacg      120

ttggccaggc tggtgtccag attggcaatg cctgctggga gctctactgc ctggaacacg      180

gcatccagcc cgatggccag atgccaagtg acaagaccat tgggggagga gatgactcct      240

tcaacacctt cttcagtgag acgggcgctg gcaagcacgt gccccgggct gtgtttgtag      300

acttggaacc cacagtcatt gatgaagttc gcactggcac ctaccgccag ctcttccacc      360

ctgagcagct catcacaggc aaggaagatg ctgccaataa ctatgcccga gggcactaca      420

ccattggcaa ggagatcatt gaccttgtgt tggaccgaat tcgcaagctg gctgaccagt      480

gcaccggtct tcagggcttc ttggttttcc acagctttgg tgggggaact ggttctgggt      540

tcacctccct gctcatggaa cgtctctcag ttgattatgg caagaagtcc aagctggagt      600

tctccattta cccagcaccc caggtttcca cagctgtagt tgagccctac aactccatcc      660

tcaccaccca caccaccctg gagcactctg attgtgcctt catggtagac aatgaggcca      720

tctatgacat ctgtcgtaga aacctcgata tcgagcgccc aacctacact aaccttaacc      780

gccttattag ccagattgtg tcctccatca ctgcttccct gagatttgat ggagccctga      840

atgttgacct gacagaattc cagaccaacc tggtgcccta cccccgcatc cacttccctc      900

tggccacata tgcccctgtc atctctgctg agaaagccta ccatgaacag ctttctgtag      960

cagagatcac caatgcttgc tttgagccag ccaaccagat ggtgaaatgt gaccctcgcc     1020

atggtaaata catggcttgc tgcctgttgt accgtggtga cgtggttccc aaagatgtca     1080

atgctgccat tgccaccatc aaaaccaagc gcagcatcca gtttgtggat tggtgcccca     1140

ctggcttcaa ggttggcatc aactaccagc ctcccactgt ggtgcctggt ggagacctgg     1200

ccaaggtaca gagagctgtg tgcatgctga gcaacaccac agccattgct gaggcctggg     1260

ctcgcctgga ccacaagttt gacctgatgt atgccaagcg tgcctttgtt cactggtacg     1320

tgggtgaggg gatggaggaa ggcgagtttt cagaggcccg tgaagatatg gctgcccttg     1380

agaaggatta tgaggaggtt ggtgtggatt ctgttgaagg agagggtgag gaagaaggag     1440

aggaatacta attatccatt ccttttggcc ctgcagcatg tcatgctccc agaatttcag     1500

cttcagctta actgacagac gttaaagctt tctggttaga ttgttttcac ttggtgatca     1560

tgtcttttcc atgtgtacct gtaatatttt tccatcatat ctcaaagtaa agtcattaac     1620

atcaaaa                                                               1627


<210> 1124
<211> 439
<212> DNA
<213> Homo sapiens

<400> 1124
cacagcccgc ggccccgagc ctgagcagat gggcctggca ccctgctgca cccaggcact       60

gtgtggcctg gccctgcggc atcacagcca cctgcagcag atcagactgg agttccatag      120

actttctgaa gaaaacactt tgttgaaaaa cgatctggga agggttcggc aagagcttga      180

agctgcagaa agtactcacg atgcacagag gaaggaaatt gaggttttaa agaaagacaa      240

ggaaaaggcc tgctctgaga tggaggtgct caacagacag aatcagaact acaaggatca      300

attatcccag ctcaatgtca gggttcttca actgggacag gaggcttcta cccaccaggc      360

ccaaaacgag gagcatcgtg tgaccattca gatgttaaca cagagcctgg aggaggtggt      420

tcgcagtggg cagcagcag                                                   439


<210> 1125
<211> 7018
<212> DNA
<213> Homo sapiens

<400> 1125
gaggccggcg cgctggcggg cgaggagcgg cggcggtggc ggccgctgga catgggaaag       60

cggaaccacc aaaaggagtg atgatcaacg atctcatgat aaatctggat gctagttctc      120

atgcctcagg acatcctact gggaacgaca caccagctcc tgggatcaga ctttcatcta      180

cttaggaccc ctctttgccc agactactaa agccagtctt cactagccac gaatggctac      240

ccaaaggaaa cacttggtga aagattttaa tccttacatt acctgctata tctgtaaagg      300

gtatctgatc aagccaacaa cagtgacgga atgcctccat acattctgta agacttgtat      360

tgttcagcac tttgaagata gcaatgattg cccaaggtgt ggcaaccaag ttcatgagac      420

aaatccatta gaaatgttga ggttggacaa tacattagag gaaattatat ttaagctggt      480

ccctggacta cgagaacaag aacttgagcg tgaatctgaa ttttggaaga aaaataagcc      540

tcaagaaaat ggacaagatg atacttcaaa agctgacaaa ccgaaagtag atgaagaagg      600

tgatgaaaat gaagatgata aagattatca cagaagtgac ccacaaattg ctatctgtct      660

agattgttta cgaaataatg ggcaatcagg ggacaatgta gtaaagggtt taatgaagaa      720

attcattcga tgttctacac gtgtaactgt gggaactatt aaaaaatttc taagtttaaa      780

actaaaactt ccaagttctt atgagttgga tgtgctgtgc aatggtgaaa ttatggggaa      840

ggatcatact atggaattca tctacatgac aagatggcga ctaagaggcg aaaactttcg      900

gtgtctgaac tgctcagctt cgcaagtctg ctctcaggat ggccctttgt atcagtcata      960

ccctatggta ctgcagtatc gaccaagaat tgatttcggt tagaccaagg ggcccagacc     1020

tcactgagat gaatcctgca ctatttgttt actcgtcaac agattgcaca gttaacggtg     1080

tgtggactag aggaacacaa ccagattttc agcatgcaaa taaggccatt gtctatctct     1140

aaattgtcag ttgcattcat gttgtttcta ttaggagcaa accaagtgcc attctgctac     1200

tgaaccatct gcataaggta tttgtgttgt ctcaaagtgt gcaagtcatg gtaaaaatca     1260

gttagctgtg ccgccatgat tcacccttct gaatattttg cttgcctgtt ccaagattgt     1320

tctaatgttt aattacacta gtaaaatggc tcaatttttg tggtgttgca gttttcacat     1380

acttactctt ttattcttgt ttaaatagcg tactctacaa gaaactaata attatatctt     1440

gaaattattt tgtatggaag tatatttaga aaagtggttt ttgagccact gtcttgttct     1500

tgataagctt tttgtgtgaa aaaaagttca ttcttgagtg tgcaagtcct tttgccaaga     1560

attccaatta ttctgtaaca ttagagcaca atataattgt agacattcta agcatctgtc     1620

cgtgtagtct accaattgca caaggaaggc atgttagccc tccagattga aaatgtatgt     1680

gacctcttga actgaagtta gattcccaac cattcaaaat gttggcagct gatcacattt     1740

acttctgata aaagtaatgt gtaagtaagg ttaatcttct ttcataatgc cttatgacaa     1800

gcaggtgctg cttcatgaaa cgtcattgta tagcccattt catgtatcat tacattgttg     1860

ctgttattta atgagtgcat tatttctctt tttaagttgg ccttaggtat atgtcattgt     1920

ggcatgcaga gggttatgac gattttaaat attaggattt ttagagcaca taacattagc     1980

tattttatgg atttcaaaag tctcaaaaca gttgtagatt aaaactgtta gttacctttc     2040

acatttccaa actatgtgca taaaatagaa taaatgcagt atagaactat gctaaccaaa     2100

attaataggt taagggtatt ttattttaaa tcctgtagta attggggaaa tgagaagatt     2160

attattttat acatgagttc attaagatca gaaatacaaa atgtcctgta ttttgcagtt     2220

ttgttaagtc ttccattcgt tttaggatta gtctgcaagt caaagaaagt cttgttacct     2280

taaattatat gaaaactgtc attttaaatc ttttaatatt tacagttttc aaaaacctta     2340

cttggaaatt gctttgaaac aaacaagcta acctttgaaa cttaggaaaa aatcttgaaa     2400

gttaggaaaa atatttgaga aatatgacga gcacaatctg tgtgttacac acatttagtt     2460

tttatactgc atatgtggta aatgtgtcac attttccagt aaaatgtatc agaaatcaat     2520

gccttctgaa tttcaaaatg attcttagaa ataagatatt gtacaactct agcaaacata     2580

caaagtacag ctaaatctta atatatttca ctatgtaaaa ggctgaaact tcataattat     2640

ctgttccttc tatctttttt tgagtcaaaa agtctattaa atttttctgt tgttgttcca     2700

actttggtga aaaaggttat ggcaatactt taactttgtt ttgttacatt gtttttgttc     2760

ttggaatggc tcacaagcag aatttaaaag gcagattttc attaactata aatggctgaa     2820

aaaactgaat ttactatcta gctacagaaa ttatttttct atggtgtgaa actgttccca     2880

gacatcccta agaactttta caaattatta taaatttgtc acacctaggt cagcgattaa     2940

aatagtgttt tgcaaatgga attttaatta actcaaaatg aattaagagt gcattttaaa     3000

aatcacaagt gagactttga tgttttggcc ccccagccaa aacttaatgg tcataaatga     3060

attttatcta caaaatctct ttaaatttgg ctggttgcct tgtcatatgt aatttcacta     3120

ttttccaagg aaatatatag gaagcaatta tgaaactgag aatagtttta tatagaattc     3180

ttttatttac tgataatgca ttaacatttt tattgaaatg caatggaata tgtgccaaaa     3240

cacgtgaaaa gcttacataa agaaaggcat cagttgtcgt ttggagaaag gtacacattt     3300

ttttgatggt cctaagtgat atggtattac tactagaatc acagatttct tcaactgact     3360

tattttggta tattcaacta cagctttcta aggataggac tactttcatg tctagtaata     3420

cactgtattc cccgttaatt atcccttaag tcagattgta gaatttgcaa gaaactaggt     3480

atagaaaaaa tgtacaggca acttttgtgg ttagctttat aaatttaggg tgcttataaa     3540

atgataaaat gaattcttta aataacctat aggaatcatc tgaatctgta acatcagaga     3600

ctaaaactaa aagttttctt taatctgttg tttcttaagc aataaactga aagaccttta     3660

cttccataaa agattttgtt atctctttta tctgccttag aaattataag tataaaaggg     3720

tcaagggaac ttagatataa agaatgactg tggtttataa acattacttt aattgaagta     3780

atcacatcag ttaatagaga aatcaaaata tgtatggcct tttctctaga ttagcaaaac     3840

agctttacaa agtatgaaaa aataaactaa aatgctcatt gatgaggtaa tactcagtct     3900

ggagtacagg taacttgggt aatgcctttt aactactctt agaggagtat attatttctt     3960

tatacattaa acatctatcc catagtaatg tgccacattt tataaacgta atgactttgc     4020

tcaactacat tacacactca aatgtaatct aaatttaaac tgattattta aggaaaaaaa     4080

gtgtgttata taatattgtg aactgtttag ctttactgaa atatttaaga gaaagtgcct     4140

cattactaaa gtgcatttct gttttaaatt tactgcataa agtttgagtt atctgtacct     4200

gtctcttatg aatggtttca tatctaaata ggctcttgta agttaatttt tttggaagat     4260

tttcataaga atatagatat caccaaagac attttacagt aaattaataa ccatgttgga     4320

gagacggttt taacagtttg gaggttggaa atttttagat tgcaatttaa ttttatatag     4380

ttaggcaata accttgatta attgctaaaa tatcaccaaa gaaaggcttt aaactgaatt     4440

ttcttggtga gatcagtcaa atgcaggctt ttcttgcaat aatcagaaca cacttccttt     4500

caaatatgtt cattgttttt cagcatcatc taacagatct tagtaaatct aaatcctcaa     4560

agatgagaaa gaggtaaaca caacaaatag ccttcctctg catgaaaagt gagagaaata     4620

catactttga aaagaaagtt cagattttta atttgagagg gtttttattt catggaggca     4680

gtgttaacta aaattaagct tagatttagc tcctgtatta ttcataatat gagaaatttt     4740

attaaaggca gactttggta aaagtgccaa cacacttact tgtatagaaa agacttcatt     4800

ctatgggatt tatataagta agtgctttct ctatattcaa aatatttcat aaggacctgt     4860

ggtttttttc cccttaaaaa gcaactctag gccgggcaca gtggctcatg cctgtaatcc     4920

cagcactttg ggaggccaag gcaggtggat cacttgaggt caggagttcg agaccagctg     4980

gttaacatgg tgaaacccca tctctactaa aaatacaaaa attagccagg tgtggtggca     5040

cgcgcctgta atcccagcta catgggaggt tgaggcagga gaatctcttg aacccaggag     5100

gtggaggttg cagtgagccg caattacacc actgcactcc agcctgggtg acacagcgag     5160

tctccatctc caaaaaaaat tcaactcttg gtcttgtttc tcagcactta gtttattgtt     5220

attagaattt agccatacag ccaactttga caaaatgggt cacagaacaa gcatgtacat     5280

caagaggaag ttccatatcc cccttgtacc atttctcctt gggaactcat gctatgggct     5340

accttaaagg taaaactcat cttatggagt ctttctgata ggtcactagg taaaactcct     5400

tggatagggt gaaaatggat gcacactcta ttacatactc tggtttatca taaggaattt     5460

tccagaaagc taagctttat actaataaga tattggttgg tagtaggaac ttcaaaaatg     5520

aatgagtttg ccataacttt aattttctgg attagaaaca caaaacttga aatgcaatta     5580

tcaatatttt gtaatatata ttcctacagt ttgggtagaa ataaggaaca tgtctgctag     5640

atctggttta tgaaaaagtg aaaaatatta aatacaccag agactcaaac cctttcaagg     5700

cacacaataa ctgttctgga tttacctgac aaacctagtt gagtagcatt ttgacagaaa     5760

atatcagact gaaagttcat tcaaatgtac ttaaatgtac aatacagtgt tcaatagttt     5820

ttattgcagt gatgtttttc caataattta agtaattctc ttcctagtat aatacagttt     5880

tcataaataa tgtttacttg ctttctttat attttcaaat aaaattaaaa tgctcgagca     5940

cttcctttca gaaagttata aaattaaaaa taattatttt aaatgctcat tcaaatgtgt     6000

ctgtatactt gctatgcccc tttttctata attccaaact gagactgatt tttcagagat     6060

ttttaacttt aataatttta aatctagaat caagtgaaac agatatgtta aatactgagt     6120

ctagttttct tccatcttat ggagcttcat ggaataagaa actaatctag tgcaaatgaa     6180

gattaaatat ttctgggtga tggagagata gtcaacaaat ttatttatcc atcctctgca     6240

catcagtcca ctggagcagg agttctacac attaaaaatg taatgggatc agcctagcat     6300

tgtttggtgt tcttttgttg tattttttag aatgggggtg ggggcctaag tgtccttatg     6360

aagctgtggt ccacgacagg agcttgttgg gggagtacca gggttctgct gctttcctgc     6420

atctgagcaa cacaacagag atcatcagtt ttaaatagag tagccctcac aatcaaaata     6480

tcatagaata tattgtaaag ttatgttgct aattttcctt tgaaatataa aatattttaa     6540

gctttttgtc aaaagtggta acatcttaat acaaataaaa acctttttgt ggttgtaaga     6600

tttagcttat aaatcattca aattgaagtg aaagaattac caggtcattg ttaatgactt     6660

agtctattaa gaatatatgt atttttgtaa aggaaaagca cttgtagata tttaatcagt     6720

acaagatatg tcttttgcag aaataaaatg ctgcttagag attctcctta aatatttttt     6780

atttttgtgc tcaaatgtat tttctgttga tctatggaat gttctgtaca aagctgtata     6840

attgtactgt tgggctagat actttttttt tttaatctgg acttagccaa gtatatttca     6900

ccatgttaaa atacagtatc tttgttatta aaaattaaat tgcataattt attattgttt     6960

gtcatcttta atattagtca ctgtagattg cagccttcat taaaaatatc tcctttaa       7018


<210> 1126
<211> 6924
<212> DNA
<213> Homo sapiens

<400> 1126
ggtagcgggg acgcttaggc agggcctgcg cccagtttag aggccaatgc ttctcccgtc       60

ctttgcatgg cacccaagaa ggagaaagga ggaactgtga acaccagttc taagatatgg      120

gaaccctcgc tcatagctgc acagttcaat cagaacgatt ggcaggcctc cattgctttt      180

gtggttggga accagattga agatgatctt ctcatccaag cccttaccgt ggctgtccag      240

gtccctcagc gtaaactctt cagtatggtg tcgtggcaag acattctcca gcagattaat      300

gaaataaata cacttgttgg atctgcttca tctaaaaagg caaaaaaacc tgtaggtggt      360

aatgctcctt tatattatga ggtgttaacg gcagcaaaag caattatgga tagtggagag      420

aaattaacct taccactgat agggaaactc ttgaaatttc aacttctcca gattaaattt      480

aaggaccaac agcgacggga aaatgaaaag aaggtaatag aagacaaacc taagttagaa      540

aaggataaag ggaaagcaaa atctcccaag gagaaaaagg ctccaagtgc caagcctgcc      600

aaaggaaagg gaaaggatca gcctgaggca aatgcaccag tgaaaaagac cacccagtta      660

aagcggagag gagaagacga ccacaccaat cgttacattg acgatgagcc agatgatggt      720

gcccaacatt acattatagt tgtgggcttt aacaatcctc agctattagc aattatggct      780

gagcttggca ttcctataac cagcgtgatt aaaatatctt cagagaatta tgaacctctg      840

cagacacacc tggcagcagt taaccagcag caggaagttc ttcttcagtc agaagatcta      900

gaagcagaaa aattgaagaa agaaaatgcc ataaaagagc ttaaaacttt ctggaagtac      960

ttggaaccag tcctgaataa tgagaaacct gaaacaaatc tctttgatgt tgctcgactt     1020

gagtacatgg tcaaagcagc tgattttcct tctgactggt cagatggtga gatgatgctg     1080

aaattgggca ctgatatttt tgaaaatatt gcctgcttga tgtatgacat cctggattgg     1140

aaaaggcagc accagcacta tttggaaagc atgcagctta ttaatgttcc acaagtggtt     1200

aatgagaaac ctgtattaga agccatgcca acttcagagg ctccacaacc tgctgtacca     1260

gctcctggaa agaagaaagc acagtatgaa gaaccgcaag ctccaccacc agtgacttca     1320

gtcatcacaa ctgaagtaga catgagatat tacaattatt tgctgaatcc aattcgagag     1380

gaattcattt ctgtgcccct gatactgcat tgtatgctgg aacaggttgt tgcaactgaa     1440

gaagatctcg tcccacccag tctgcgggag ccatccccca gagcagacgg gctagaccac     1500

agaatcgcag ctcacattgt gtcccttctg ccctcactct gtctctcaga gagggagaaa     1560

aagaatcttc atgacatatt tttatctgaa gaagaaaatg aaagcaaagc agtgcccaaa     1620

ggccccctcc tactgaacta tcatgatgca cacgcccaca agaagtacgc actacaggac     1680

caaaagaatt ttgatccagt tcaaattgag caggagatgc agtccaagtt gccactgtgg     1740

gaatttcttc aattccctct acccccacca tggaacaaca ctaaacgtct agctacaatt     1800

catgagctta tgcacttttg tacgagtgat gtcttgagct ggaatgaagt agaacgagcc     1860

ttcaaggtgt ttacttttga gagcctgaag ctctctgagg ttgatgaaaa agggaaactg     1920

aaaccttctg ggatgatgtg tgggtcagat tctgaaatgt tcaacatacc gtgggacaac     1980

cctgccagat ttgctaaaca gataaggcag caatatgtca tgaaaatgaa tactcaagag     2040

gccaagcaga aagcagatat taaaatcaaa gacagaacac tatttgtgga tcagaatttg     2100

tcaatgtctg tgcaagataa tgaaagcaac cgagaacctt cagatcctag tcagtgtgat     2160

gctaacaata tgaagcattc tgacttgaat aatctcaaac tctcagtccc tgataataga     2220

cagctgttag agcaggagag catcatgaag gctcagcccc aacatgagtc tctggagcag     2280

accacaaaca atgagatcaa agatgatgca gtcacaaagg ctgattctca tgaaaagaaa     2340

cccaagaaga tgatggtgga agcagattta gaggacataa agaaaacaca gcagcgcagt     2400

ctaatggact ggagttttac tgaacatttt aaaccgaaag tactgcttca ggtccttcaa     2460

gaagcccata agcaatatag gtgtgttgat tcttactacc acacccaaga caactcttta     2520

cttttagtct ttcacaatcc aatgaataga caacgtttgc attgtgaata ttggaacatt     2580

gctctccact ccaatgttgg attcaggaat tatttggaac ttgttgcaaa atctattcaa     2640

gattggatta caaaagaaga agctatatat caggaatcta aaatgaatga gaaaatcatc     2700

aggaccagag ctgagctgga attgaaatct tctgctaatg ccaaacttac ttctgctagc     2760

aaaatttttt ccattaaaga atctaaaagt aacaaaggaa tcagcaaaac agagatatca     2820

gatcaagaaa aagaaaaaga gaaggaaaag attcctttca ttttagaagg ctctctcaag     2880

gcatggaaag aagagcaaca tcgattagca gaagaggagc gcttaaggga agaaaagaaa     2940

gcagagaaga agggtaaaga agctggtaaa aagaaaggca aggataacgc agagaaagag     3000

gatagtaggt ctttgaagaa aaaatcacct tacaaggaga aatctaaaga agaacaagtc     3060

aagatccaag aagtaacaga agagtccccc caccaaccag aacctaagat aacttacccg     3120

tttcacggat acaatatggg aaatataccc actcaaatct cagggtcaaa ttactacctg     3180

tatccttctg atggggggca gattgaagtg gaaaagacaa tgtttgaaaa aggcccaact     3240

tttatcaaag tgagagtggt aaaggacaac cacaatttta tgattcattt aaatgaccct     3300

aaggaaattg tgaaaaagga agagaaaggg gattattatt tagaagagga agaagaagga     3360

gatgaggaac aaagtcttga aacggaagta tcagatgcaa agaataaagc tttcagcaag     3420

tttggatctt tttctgccac cttagaaaat ggaatctgcc tctcgataag ttactatgga     3480

tcaaatggaa tggcaccaga agataaggat cctgatttag aaacaatatt gaatatccct     3540

tcagcactca ctccaacagt ggttcctgtt atagtgaccg ttcctcaaag caaagctaaa     3600

gggaaaataa aaggcaaaga aaaacccaaa gaatccctta aagaagaaga acacccaaaa     3660

gaagaagaga aaaaggaaga agaagtagaa ccagaacctg ttttacaaga gactttggat     3720

gttcccacct tccagagcct aaatgtgtct tgccccagtg ggctcctgtt gactttcatt     3780

ggacaagaat ctacaggtca atatgttata gatgaggaac ccacctggga catcatggtc     3840

cgtcagagct acccccagag ggtgaagcac tatgagttct ataaaacggt gatgccaccc     3900

gcagagcagg aggcttcaag ggttatcacc agtcaaggca ctgttgtcaa atatatgttg     3960

gatggatcca cacagattct ctttgcagat ggtgctgtga gcaggagtcc caattcaggt     4020

cttatttgtc ctccttctga aatgccagca acgcctcaca gtggagattt gatggactct     4080

atttctcagc agaaatcaga aacgatacca tctgagatta ccaacacaaa gaaaggaaaa     4140

agtcacaaaa gtcagtcatc aatggcccat aagggtgaaa tccatgaccc tcctccagag     4200

gcagttcaaa ctgtaactcc tgtggaggtt cacataggca cctggtttac aaccacacct     4260

gaaggaaatc ggatcggcac caaaggatta gaaagaatag cagacttgac cccattgtta     4320

tcctttcagg ccacagatcc tgtcaatgga acggttatga caactcgaga agacaaagtt     4380

gtcatagttg aaaggaaaga tggtactcgg atagtggatc atgctgatgg taccagaatc     4440

acaacctttt atcaagttta tgaagatcaa attattctgc cagatgatca agaaacaacc     4500

gagggtcctc ggactgtcac caggcaggtg aagtgtatgc gggtagaaag ctcacgctat     4560

gccactgtta tcgccaactg tgaggacagt agctgctgtg ccacctttgg agatggaaca     4620

actattattg caaagccaca gggaacatac caggtgttac ctccaaacac aggctctctt     4680

tatattgaca aggattgttc agctgtgtac tgccatgagt caagcagtaa tatatactat     4740

ccttttcaaa agcgtgagca gctgcgagct ggcaggtaca tcatgaggca tacttcagag     4800

gttatctgtg aggttctgga tcctgaggga aacacttttc aggtcatggc tgatggtagc     4860

atatcaacta tattacctga aaaaaaattg gaagatgatt taaatgagaa aactgagggc     4920

tatgatagtc tgtcctctat gcaccttgaa aagaatcatc agcaaatcta tggtgaacat     4980

gtccccaggt tttttgttat gtatgctgat ggatcaggaa tggaacttct tcgagacagt     5040

gacatagaag aatatctatc tttggcatat aaagaatcaa atactgttgt tctccaagag     5100

ccagtgcagg aacagccagg caccctaacc atcacagtcc ttcgcccttt ccatgaagca     5160

tcaccatggc aagtaaaaaa ggaagataca attgtccctc ctaatctccg gtcaaggtca     5220

tgggaaacat ttccctcagt tgagaaaaaa actccaggac ctccgtttgg tactcagatt     5280

tggaaaggcc tttgcattga gtccaaacag ctagtgagtg ccccgggtgc catactcaag     5340

agccccagtg tgctacagat gcgccaattc attcagcatg aggtcataaa gaatgaggtg     5400

aaactgaggc tgcaggtttc ccttaaggat tacataaact atattctaaa gaaagaagat     5460

gagctgcagg aaatgatggt taaagattcc agaactgagg aggagagagg caatgctgct     5520

gatctcctca agctggttat gtctttccct aaaatggagg aaactacaaa aagtcatgtt     5580

actgaagttg cagctcacct aactgattta ttcaagcagt ctttggctac gcctccaaaa     5640

tgcccaccag acacatttgg taaagatttc tttgaaaaga catggagaca cacagcatcc     5700

tcaaaacgct ggaaagaaaa gatagacaaa acgaggaagg aaattgagac aacacagaat     5760

tacctaatgg atattaagaa ccgcataata ccaccctttt ttaaatctga attgaaccag     5820

ttatatcagt ctcagtataa tcacctggac agtctttcca aaaaactgcc ttcttttaca     5880

aagaaaaatg aagatgcaaa cgaaacagct gttcaagata catctgatct taatctagat     5940

ttcaagccac ataaggtttc agaacagaaa tcctcaagtg tgcctagtct tccaaaacca     6000

gagatttctg cagataagaa ggatttcact gctcagaacc aaactgaaaa tttaacaaaa     6060

tctcctgaag aagcagaatc ttatgagccc gtgaaaattc caacccagtc cttgctgcag     6120

gatgttgcgg gacaaacaag aaaagaaaaa gtgaagttgc ctcattattt gctgagttcc     6180

aagcctaagt ctcaacctct tgcaaaggtg caagattctg ttggaggaaa agtgaacaca     6240

tcctctgttg catctgctgc cattaataat gcaaagtcat ccctttttgg gttccatctt     6300

ctcccatcat cagtcaagtt tggagtgctt aaggaaggac atacctatgc cacagttgta     6360

aagctcaaga atgttggagt ggacttctgc aggtttaaag taaagcagcc cccacccagc     6420

acaggactga aagtgactta caaacctgga cctgtggcag ctggtatgca gacagaactg     6480

aatatagagt tatttgccac agctgttgga gaggatgggg ccaagggatc agcacacatc     6540

tctcacaata tcgagattat gacagagcat gaggttctgt tcctacctgt ggaagcaact     6600

gttttaacaa gcagcaatta tgataaacga ccaaaagact ttccccaggg aaaagaaaat     6660

ccaatggtcc agagaacttc tacaatttat tcctccacac ttggagtctt catgtctcgt     6720

aaagtttctc cacattagtt tcttctcggt acaactcaat agcctccata atcctctcag     6780

cctacagagg atgagaaagg aaagaagtca tcacaacata ctccatcatc ccaggacact     6840

gaaactggaa gaactgacca gaaatttgcc aaatgaaata gcttcaatct gtttaataaa     6900

gacgtgcgaa tagagtgcca aaaa                                            6924


<210> 1127
<211> 7582
<212> DNA
<213> Homo sapiens

<400> 1127
agacagtaag gagccagggg aacagagaga attgtggggc agcaccgctc cttgggtccc       60

cactccccat ttctcattgc ttggaaatcc atgccaagat gcctgccttc cttggtctaa      120

agtgtctggg gaaattgtgc agctctgaga aaagcaaagt cacctcatct gagagaacca      180

gtgccagggg ctcgaacaga aagagactga ttgttgagga ccggagggtc tctgggacct      240

ccttcaccgc tcataggcgt gccactatca ctcatttgct gtatctctgt cccaaggact      300

actgcccacg tgggcgtgta tgtaacagcg ttgatccttt tgtggcccac cctcaggacc      360

ctcaccaccc atcagagaag cctgtcattc actgccataa atgtggggag ccttgcaagg      420

gtgaagtgct tcgggtccag accaaacatt tccacatcaa gtgtttcacc tgcaaagtgt      480

gtggctgtga cctggcacaa gggggcttct tcataaagaa cggagagtat ctctgcaccc      540

tggactacca gcggatgtac gggacacgct gccatggctg tggggagttc gtggagggcg      600

aagtggtgac tgctctgggc aagacctacc atcccaattg ctttgcttgt actatctgca      660

agcgcccgtt tccacccgga gaccgagtca cattcaatgg gagagactgc ctttgtcaac      720

tctgtgcaca gccgatgtcg tccagtccga aagaaaccac cttctccagc aattgtgccg      780

gctgcggaag agatatcaag aatgggcagg cgctgctggc gctggataag cagtggcact      840

tggggtgctt taaatgcaag tcctgcggga aggtcctcac cggggagtac atcagcaagg      900

atggtgctcc gtactgtgaa aaggactacc agggactctt tggggtgaaa tgtgaggcgt      960

gtcaccagtt tatcacaggg aaagtcctgg aggcaggtga caaacattac caccccagct     1020

gtgcacgatg cagcagatgc aaccagatgt tcacagaagg agaggaaatg tatcttcaag     1080

gctccaccgt ttggcatccc gactgtaagc aatctacgaa gaccgaggaa aagctgcggc     1140

ctaccaggac atcctcggaa agtatttatt ctaggccagg ctccagtatt cctggctcac     1200

caggtcatac tatctatgca aaagtagaca atgagatcct ggattacaag gatttagcag     1260

ccattccgaa ggtcaaggca atttatgaca ttgaacgtcc agatcttatt acctatgagc     1320

ctttctacac ttcgggctat gatgacaaac aggagagaca gagccttgga gagtctccga     1380

ggactttgtc tcctactcca tcagcagaag ggtaccagga tgttcgggat cggatgatcc     1440

atcggtccac gagccagggc tccatcaact cccctgtgta cagccgccac agctacactc     1500

caaccacgtc ccgctctccc cagcatttcc acagacctgg caatgagccg tccagcggcc     1560

ggaactcccc tctcccttac cggccagaca gccgccctct aactccaact tacgctcagg     1620

cccctaaaca tttccatgtt ccagatcaag gaatcaacat ttaccgaaag ccacccatct     1680

acaaacagca tgctgccttg gcagcccaga gcaagtcctc agaagatatc atcaagtttt     1740

ccaagttccc agcagcccag gcaccagacc ccagcgagac accaaagatt gagacggacc     1800

actggcctgg tcccccctca tttgctgtcg taggacctga catgaaacgc agatctagtg     1860

gcagagagga agatgatgag gaacttctga gacgtcggca gcttcaagaa gagcaattaa     1920

tgaagcttaa ctcaggcctg ggacagttga tcttgaaaga agagatggag aaagagagcc     1980

gggaaaggtc atctctgtta gccagtcgct acgattctcc catcaactca gcttcacata     2040

ttccatcatc taaaactgca tctctccctg gctatggaag aaatgggctt caccggcctg     2100

tttctaccga cttcgctcag tataacagct atggggatgt cagcggggga gtgcgagatt     2160

accagacact cccagatggc cacatgcctg caatgagaat ggaccgagga gtgtctatgc     2220

ccaacatgtt ggaaccaaag atatttccat atgaaatgct catggtgacc aacagagggc     2280

gaaacaaaat cctcagagag gtggacagaa ccaggctgga gcgccactta gcccctgaag     2340

tgtttcggga aatctttgga atgtccatac aggagtttga caggttacct ctttggagac     2400

gcaacgacat gaagaaaaaa gcaaaactct tctaagtccc actcgtgaat ggcaattaga     2460

gaaaggactg acagtggcgg tgccccatag gatgtcatat tgaggcccaa acttgattgg     2520

agaatttgca aactaccgtc gctcagcaac accaaaaaga gaaagtctgg ttaaaacacc     2580

atgagtcaaa tgtcgggcca gccaacagta acacttgcca agaagcatgg cgtagaaatt     2640

tctatgttcc gaaacacaga gtagtgtcca catgtgagct tttcacatta ccttatgtat     2700

acaacaggag ctgcgttgtt ttcttctttt tcttttcctt tatctgttgt ccaacaacag     2760

tgctgactgt ccggataaga gctggcaagt gcccttagga tgccgcatgg gaaaaatcgg     2820

ttatcataat ttcaaagtat aaatatattt attaagtagc gctgcggcta agaaggaaga     2880

gtgaggggtc tgtccatggg gtggcagtga tttcacaccc gcctttcttg aatggcttcg     2940

tgttactcag ccgtgccctg gcaggaatgg aactccatca gggaacaggg cagctctgtt     3000

tgaatggggt gaaaaacagc aaaattaatt cttagcaagc tccttgttct ctactgttca     3060

ccgggacctg gctggcaaat gacttagcta ttagtatatt taaaaactgt tcaaaagcaa     3120

aagagaagga acaggaatga aaggaaacct tcccttaact ctttctgctt cccatagcag     3180

gtctggttcc tgctccccgc ctaggacagg agctgtctgg agctccacct ttgcaaagaa     3240

aggaaaaaca caaattgccc ccagattggc ccagtggcat gccattaggt gattttgcat     3300

aggggccata tcattcatgg ccaaaaaaaa ccaaaaagca aaaaacaaaa acaagtccca     3360

tgtcctactg actctagttc ttccagtcgt tatcctctgc tgtctctctg gcatcctatg     3420

aatcagatca agcccatgct gttgttggtt tttaaggttt ctttcaataa taggctaagg     3480

aaagacatgt ttttctcttt taaatctctg caactccaaa gtagactcct tcgaacgtat     3540

ttaatttggc cttttcagct ttcttcttgc ccagctctgt cgaattcatg ggtgtgtgtg     3600

cacatgttgg tttcactcac ccagagtaat tttgtgagca tgcatgtgct ttttaatttc     3660

tgcttgaatg tttgtcctgc tgtgttgcag cttctaaaga cattgtcacc gagtgtgtgt     3720

gactcaaaga tcaagagtga ggctaaactg cgaccccaac atcacttcct tcatggaaag     3780

gtgttggcgc tgatgtagct catggaagga tcagactggg aaccacagag gaaggatgag     3840

gtgggatgtg gaggtcagag catctcacga gagtccctca ggctctgcaa cactagattc     3900

gaatatgagc ctagggtttc cccaacacgt gcgtgcatat gaaaccacat catgattccc     3960

gacgtgagtt agatgaggga gagtttgtgt aactccacac ccaggagggt aagccacttt     4020

attatcatgc tttggggctg tgcttaagaa tttaagctct gttttaaagc cgaagaagaa     4080

aacatttgaa tttaccttca tatgccacta agaacaaaag ctctgaagtt cttcctgctg     4140

gcaccaaata ttaggattac aagctgtctc tctgacacca gtggtaaaaa agcaagtaga     4200

atagtttctg agtctgtgtt gcagcctctg acacgtggct caccgctgtc atttggggga     4260

tggaatgaac agtcactgtt ctatagcatc ctcctgtgct cttacctaag gaatctaaat     4320

tgtcctagcc ttccattgct atgcactgaa tgaggactac tctcgtgtgt gtgtgtgtgt     4380

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttggatc tactaacatg tttagcaaat     4440

ggctctgaca gggtggccat gagcagatga gaccagctct tgcttggttg gaagccacac     4500

tgcagtttgc agtttagcct ttggtgtctc agtggcttct tgcttattcc atgctttttc     4560

tatcccatcc tctctctgtg ccctcctgca atggcagcct tggcacaatg cctgggtgtc     4620

ctcatccttg ctttactctg gaaagtgtgg ggatggagag gatggtgcat ttccagtgct     4680

tccttacctg tcaataacaa tggtggccac ctgggtccca gcacttggct ggtggagaga     4740

tttttttcat tatggagcta ataaagggtc cctacgtttt acattgatta atgaattatc     4800

acccagacat gtgcagatga aatgtcaata taagaaaaat caaggtattt gggaaacatg     4860

ggcataatca ggtagttttg ctaaaattcc tcttccttgg tctacataaa gaagacatgg     4920

gtctgtcata gaatggggac attagactga aaactgggac aacccccttc cttattttat     4980

agagactagg agttaagggg cctgcctaag attgcagtga taaagaactg aaccctaaat     5040

cagctcccac taatgaaacc ctgctttcct tgtatctttt aaactcagtt ctgcatccaa     5100

cttgagaaga aaaaaagctt ctttccatat caagtaccat atgagttcat ttaaactgca     5160

ccttgcagaa atgcattgcc agaaagcacc agtagcctcc tatctgcaag cagagtagtg     5220

ctctgctctg gggaggggtc attggaaacc ataatgcaga gtgggccccc tactccattt     5280

cccagcaaaa ggctccagct ggagggatgg gttgtggggc aacctggttc ctgctaactg     5340

ccagattgaa tgtgtgggct agaatgcctg cacatttagt taaactgggc tcagcatgct     5400

tgtcctcaaa atgtccatcc tggtcacagc acacaagatg gctattggtc tgcttttacc     5460

ctaccctgta ctatacatga aaattccagt tattaacaca ctcaaactgg tggagcttgt     5520

tcaccctagg aaggggattg tatatatggc aggcttccct ggtgccgatg taaagggcta     5580

catttgggaa catttgactt ccttgggact cttaagtgca taatgatggc atgaagtaaa     5640

aggggcctca atgatgatag gaaaatcagt tcttttaaaa tttcttcaag aaaatccagg     5700

ctatcacata gtctttctgt gtgacttatt aggagatagg aagagcattg ggaaacttgc     5760

acagctagct atgcatctac attttggttt ggggttagtt atgaaatgtt cttaatatga     5820

cgtgttcaat aacttcacat aaacttcctg ttctccaaaa cctcaaagag atagagttaa     5880

tgagttgttg ttttttttta aatgggggta gttttctatc tgtcatgggc tctagcatct     5940

actccgctac ccaattctgt catctccaag ctgagtttcc tcttctgagg cagaggctgg     6000

agcagttctt tttcagttct catcctctcc atcccaatcc agtatatcaa tcaactctaa     6060

ctcggagacg tctagctggc aatgtttcta aaactttcac tggatttctt tagacattga     6120

agcaaacatt tttttctaag aattgcttct cagatgatga tatcaaatgt atatgctttt     6180

gcaagtttga aaagttcaaa ttaaccactt ttgactaggt aagtctttct aaaaaccatt     6240

taaagctaac tgggtcttag catcctcctg tgtatggaag agacaggtga ccgctccagg     6300

ttgggtgctc acagaaccct tttcctgact ctcatggaag atggtggaag gaaaatagac     6360

tgtctcatca accctcctgt gtcctctgaa gcaatctcag tttttattaa ccacctcttc     6420

tgtgtttctg gtagctattt aacctgtatt taatctgtac ttcctatgcc agcctcaatt     6480

ttatttgatt tttacaatta ttctcttcta accaatgaag tgtttgtcag tatgccccaa     6540

agcttgctct tttgtgctcc cttttgaata actttctatc cagaaaaaga gattatttgg     6600

gacttgagat ttgcagtgat accaacttat agcaatgatg tactttaagg gaactaccca     6660

actatgttgt gatagaagaa agagaaacct tcactttggc attttttttt aatcactgtt     6720

tatttttctg tttgcggccc aggaagcagt gggaggtggt ggcagatatg ctttgcatat     6780

ggattgttat gtttttattt gggcaagttt aatcatggaa aactcaaaaa gaagggggga     6840

aatggtcagt ttaagccaaa agaaactttc taaacaatgt ataggtacac agcaaaatta     6900

aacaaatcca acaatttctg aagcttagtg taattgagtg gtggttgtta ttcaataaaa     6960

ttattcccaa aagtgtttct cctaagagtg cagttcccat gagtcacttc ctgaacccat     7020

tgaccaaagg tggacagaga caatcctgta gaccttgaca ttcagaaaga tgtgagctgc     7080

ttactgatca tatatgcata cgtttcttta cagcagagga aaccattgtc cacaaaactg     7140

atgttctttt ggggttttat gtacagactt gtccaatcat gtgtgtggtt cctgcgagtt     7200

gctgatgact ccgcattgaa gctctctgag ttctttgatt ttaagttggg tttatggaat     7260

tttttcaaat gttggaaggt gtgtggttct tcctgccctc cctccccttt tggaaatatg     7320

aaagcaaatg tttagaagaa ttccttttga aaagctgtgt cgtgttccct gtgaaactga     7380

gcaggtgtgt gttggcgcgc taagtgccac atgcttgtgt gtagaggagg aggtggccct     7440

gccggctccg cgctgctgtg cctgtgatcc ctacctgctc cccgctcctg ttgccagcag     7500

cactcactgc actcctttgt catatactct gcatcactgt catactcaca acttcgtgaa     7560

taaagttgtg tgctttattc gt                                              7582


<210> 1128
<211> 2686
<212> DNA
<213> Homo sapiens

<400> 1128
tgctcctgca ccggtctgca tctcccagca gaaggcgcag ccatgaatcc gttattcggc       60

cccaacctct tcctcctgca gcaggagcag cagggcctgg ccgggccact gggggactca      120

ctgggaggcg accacttcgc cgggggagga gacttgcccc cggcgcctct ctcgccggcc      180

ggccctgctg cctactcgcc gcccgggccg ggcccggccc cgcctgccgc catggccctc      240

cgcaatgacc tgggctccaa catcaacgtg ctcaagaccc tgaacctccg gttccgctgc      300

ttcctggcca aggtgcatga gctggagcgc cggaaccggc tgttggagaa gcaactgcag      360

caagcgctgg aggagggtaa gcagggccgg cggggcctgg gtcgtcgcga ccaggcagtg      420

cagaccggct tcgtcagccc catccggccc ctggggctgc agctgggcgc ccggccggcc      480

gctgtctgca gcccttcggc gcgcgtgctg ggctcgcccg cgcgctcccc ggccggcccc      540

ctcgcgccct ccgcggccag cctctcgtcg tcctccacct ccacctccac cacctattcc      600

tcgtcggccc gcttcatgcc cggcaccatc tggtcgttct cgcacgcccg ccggctcggg      660

ccgggactgg agcccactct ggtgcaaggg cctggcttgt cgtgggtgca cccggatggg      720

gtgggcgtcc agatcgacac catcacgccc gagatccgcg ctctctacaa cgtgctggcc      780

aaagtgaagc gggagcggga cgagtacaag cggaggtggg aagaggagta cacggtgcgg      840

atccagctgc aagaccgtgt aaatgagctc caggaggaag cccaggaggc tgatgcctgc      900

caggaggagc tggcactgaa ggtggaacag ttgaaggctg agctggtggt cttcaagggg      960

ctcatgagta acaacctgtc ggagctggac accaagatcc aggagaaagc catgaaggtg     1020

gatatggaca tctgccgccg catcgacatc accgccaagc tctgcgatgt ggctcagcag     1080

cgcaactgcg aggacatgat ccagatgttc cagaagaagc tggtcccatc catggggggg     1140

cggaagcggg agcgcaaggc tgccgtcgag gaggacacct ccctgtcgga gagtgagggg     1200

ccccgccagc ccgatgggga tgaggaggag agcacagccc tcagcatcaa cgaggagatg     1260

cagcgcatgc tcaaccagct gagggagtat gattttgagg acgactgtga cagcctgact     1320

tgggaggaga ctgaggagac cctgctgctt tgggaggatt tctcaggcta tgccatggca     1380

gctgcagagg cccagggaga gcaggaagat agcctggaga aggtgattaa agatacggag     1440

tccctgttca aaacccggga gaaggagtat caggagacca ttgaccagat agagctggag     1500

ttggccacgg ccaagaacga catgaaccgg cacctgcacg agtacatgga gatgtgcagc     1560

atgaagcgcg gcctggacgt gcagatggag acctgccgcc ggctcatcac ccagtctgga     1620

gaccgaaagt ctcctgcttt cactgcggtc ccgcttagcg acccgccgcc gccgccaagc     1680

gaggctgagg actccgatcg cgatgtctca tctgacagct ccatgagata gagacctgcc     1740

tcccccttgc acccgaggcc ctcgcagcag ggagctcagc gaggcagagg gtggggctgc     1800

acagagggga acatcagctg cagctctgca ccaggccggt ccctggggac tggggcgctc     1860

ctccctcagg ctttctccct cagtcttggc ttctccaggg ctctggggtg tctggagcta     1920

ggcttggccc taccattctg gggccatttc caccacagtt ggggctctcc tgccttcacg     1980

cgtgggtgtc tgctacttcc ccatctttaa aatgctgcca gagcgattgc ggcccctcac     2040

cttgtccacg tatcaggaat gtgaatgtgg gacctttcct ccatccctgt tgtccggagc     2100

cagctcactg tcttccacac tggtgctaac tggcccaggc actggagtgg aatagaatgc     2160

agctggaggc tacgcatggc ctctgcagca cacgcagctg gagagggctt ctgtccctgt     2220

cagcggcaga gggcgttggg gctggccggg gcaccttgtc cctgctatgg tccacgtgct     2280

cacgctgtcc acctgccagg tggagtgtat gtggctgtgg ccctccctcg tggaggtgcc     2340

gtgctttaaa gaggccttag tgcccgggat gggcacagtg ttttgaaggg aggtgggagc     2400

tcttgctctc ctggtcactg cagaatgaca gagaaggtga agctccatgc atgtgtgcgc     2460

gggtgtatgt gcgctcaggg tctctgttta agtatcagct aaagatgtgc ttcctccgtg     2520

tctgtcatac actgagacca acaggctaca gtgtccctga ttcttggaaa agcctggaga     2580

agctggggag atgcggttca caatgcctcg gtataggagg ctgtgttgag ctgacattca     2640

aatggattct ttaataataa tgaaactggc gagtatttat tgtgca                    2686


<210> 1129
<211> 5427
<212> DNA
<213> Homo sapiens

<400> 1129
cgcggcttgc aaggcgcctg cgactcggtc ccaggtcggc gggcggcgca cggcgggctc       60

gcgcgggggc cccggcgcgc cgggcggcgc agtacgcagc gcgcggaccc acgccacggc      120

caggagccca gagcagcgcg gccacactgc ccaggggtcg gccctcggcc ccggcgctcg      180

gagcgcggcg gctgcctggg ctttaatggc tgctccgcgg agcagcgcct agggctggaa      240

ggcggctgcg gctcaggaag tcacccgagc aagcctcctt cggggccggc cgcacccgcc      300

gcggcgcgct ccatgggggc gcgctccccc cgggcggccc gctgacccgg gacgccgggg      360

cccgctcgct cgccggccgc gcgtcccggc catgaactga gcccgcgggc cagccccgcg      420

cctgctccgc ccgcgccttt cttctcgcgc ctcctccgcc cgccgccggc gggcccggct      480

ccccgggggc tgcggcgccc cgggctcggc ggcccgcggg ccccggggcg cggggcggcg      540

gcggcggggg gcgcgcggct ccgggcgcgg cgcctgcacc atgaactacc agcagcagct      600

ggccaactcg gctgccatcc gggccgagat ccagcgcttc gagtcggtcc accccaacat      660

ctactccatc tacgagctgc tggagcgcgt ggaggagccg gtgctgcaga accagatccg      720

ggagcacgtc atcgccatcg aagatgcctt cgtgaacagc caggaatgga cgctgagtcg      780

atctgtcccg gagctcaaag tgggaattgt gggtaacttg gccagcggca agtctgccct      840

ggtgcaccgg tacctgacgg gcacatatgt ccaggaggag tctccggaag gtggcaggtt      900

caagaaagag attgtcgttg atggacagag ctatctgctg ctgatcagag atgaaggggg      960

ccccccggag gcgcagtttg ccatgtgggt ggacgctgtt atatttgtct tcagcttgga     1020

ggatgaaata agtttccaga ccgtttacca ctactacagt cgaatggcca actatcggaa     1080

cacgagcgag attcctctgg ttctggtggg aacccaggat gccataagtt ctgctaaccc     1140

gagggtcatc gatgacgcca gggcgaggaa gctctccaac gacctgaaac ggtgcacgta     1200

ctacgagacg tgtgctacat acgggctgaa tgtggagagg gtcttccagg acgttgccca     1260

gaagattgtt gccacaagga agaagcagca gctgtccata ggaccctgca agtcgctacc     1320

taattctccc agccattcct ccgtctgttc cgcgcaggtg tctgccgtgc acatcagcca     1380

gacaagtaat ggaggtggga gtttaagcga ctattcctcc tccgttccat cgactcccag     1440

caccagccag aaggaacttc ggatcgatgt tcctcccact gccaacacgc ccacgcccgt     1500

tcgcaagcag tctaagcgcc ggtccaacct gttcacctct cggaaaggga gcgacccaga     1560

caaagagaag aaaggcctgg agagtcgtgc ggacagcatt gggagcggcc gagccatccc     1620

aattaaacag ggcatgctgt tgaagcgaag tggcaaatcg ttgaataaag agtggaaaaa     1680

gaaatatgtc accctgtgtg acaatggcgt gctgacctat catcccagtt tacatgatta     1740

catgcagaat gttcatggta aggagattga ccttctgaga accactgtga aagtcccagg     1800

gaagaggcca ccccgagcca cgtcagcctg cgcacccatc tccagcccta aaaccaatgg     1860

cctatccaag gacatgagca gtttacacat ctcacccaat tcagacacag ggctgggtga     1920

ctccgtatgc tccagcccca gtatctccag caccaccagc cccaagctcg acccgccccc     1980

ctcccctcac gccaacagaa agaagcaccg aaggaagaaa agcactagca acttcaaagc     2040

cgacggcctg tccggcactg ctgaagaaca agaagaaaat tttgagttta tcattgtgtc     2100

cctcactggc caaacatggc actttgaagc cacgacgtat gaggagcggg acgcctgggt     2160

ccaagccatc gagagccaga tcctggccag cctgcagtcg tgcgagagca gcaagaacaa     2220

gtcccggctg acgagccaga gcgaggccat ggccctgcag tcgatccgga acatgcgcgg     2280

gaactcccac tgtgtggact gcgagaccca gaatcccaac tgggccagtt tgaacttggg     2340

agccctcatg tgcatcgaat gctcagggat ccaccggaat cttggcaccc acctttcccg     2400

agtccgatct ctggacctgg atgactggcc agtcgagctc atcaaggtga tgtcatccat     2460

cgggaacgag ctagccaaca gcgtctggga agagagcagc caggggcgga cgaaaccatc     2520

ggtagactcc acaagggaag agaaggaacg gtggatccgt gccaagtacg agcagaagct     2580

cttcctggcc ccgctgccct gcacggagct gtccctgggc cagcacctgc tgcgggccac     2640

cgccgacgag gacctgcgga cggccatcct gctgctggca cacggctccc gggacgaggt     2700

gaacgagacc tgcggggagg gagacggccg cacggcgctg catctggcct gccgcaaggg     2760

gaatgtggtc ctggcgcagc tcctgatctg gtacggagtg gacgtcacgg cccgagatgc     2820

ccacgggaac acagctctgg cctacgcccg gcaggcctcc agccaggagt gcatcgacgt     2880

gctgctgcag tacggctgcc ccgacgagcg cttcgtgctc atggccaccc ctaacctgtc     2940

caggagaaac aataaccgga acaacagcag tgggagggtg cccaccatca tctgaggaac     3000

agccgtgccc gcctgctcgc cgcacctggg acgcggcagc ctcgccgcat tctcgctcag     3060

aagtcgcagc acgtgagtcc cgtcgcatcc cctccctctt cctggtggcc acctccctcc     3120

cgcccaccca ctctcacccc aaacaaaatc acaaaacctg gacatccctc aaggggcgaa     3180

gaggcggccg ggagactgca gaagtggctc cttttcataa actcccctaa accacacaca     3240

ggagagagcg acgggcctcg gccctttgat gatagcacat ggcgcaggac ccttgtcctg     3300

gtggcacaag ggatggggac gcgaggggga ggggaggcga ggaacaagga gaaggggcaa     3360

ctttccttaa ctggcagttg agcacatagt acatttcccc tctaccaaac ggaacacttg     3420

gattccatct cttctctgag gagctcgacg gcataaatca gaagcaagca cagagtttgt     3480

caggtttgaa gcccctatga tggtgtgtgt caaatcagtt gtagctaatc tgtccaggga     3540

gaatactggc ttcattacac ttgtacagcc gagttcttcc cgcattactg ctgtttaata     3600

gaacgtgatt agtcatcgcc gagaagaaag catattagcc gaggaggtag tcacgcggca     3660

cgcgccggtg attgccacga tgtgattgca atactcttag aagcaccata ttatcccaga     3720

catgttcttt caagcccttg gagccctctc taaattcact gtcatcattt agtatctgtt     3780

taatttttca gtccaaagag aggaaatcag tcgctgagta ttatttgact ccggtctcct     3840

tggtgcaaaa acaaaatggg aaaaataaat aagaataact cagaaactca aaaggaaacc     3900

acaaattcag ctaataatag catttcgagt atatttcgta aactaaggaa atacacaaaa     3960

ggctgttttt tccgactgta agagatattt gatgtccttt tgccgaggtg gatgtgttag     4020

tctcaggccc tcctggacca cgttgcccaa gtcacacagg cttctgtgtt atgtatttag     4080

ataagatgtg tgaaaatata tttgaataaa agaagttcat aaatatgcat tgatttttgt     4140

acagacaaat ggcacctctc ttaatttata aattgaactg gatgtgaact aataatgtgc     4200

aactagttga gataagaggg ttacagatca ttgtacatgg aaaatattcc cagcagtaaa     4260

cacttccatt aatgtgatct acggcttttg aaaaggagca tctcagaata agatggtggt     4320

acaatttgct tattaaaatt gagaaagaaa aaaaaagaca cactggagta tattagaaag     4380

gaaaaagaag gaatgtggtc tctcatgatt gaaagcatga tttagatcgg atacggcttt     4440

tgctaaccaa ggaccaaggg actctggcaa gatggggtgg ttttccgaat gccagaccga     4500

ggtgccttac gaaggcagct gccaatggtt ctgtggcaca gactggctcc tgagaaccca     4560

gacgaccttg acctggcagc ccggccctcc acgctagtac ctcgcctgat tttccatcgt     4620

tgcggtatcc agccgcttca gacgtccgcc gccttcagtg gtggtagtca aatgtagtca     4680

accaaaccac agcatccctt aggttaaaag caaacggggc agctttgcct agagctcatt     4740

gacagtgtga tggggggaga agggttgtca caatggaaga tgaggacact agactcatgt     4800

agcacagaaa catgaagcca cacgcaccgg cagcctccgg ggtgttcctc gctctctcgt     4860

atgttaaacc ttatatttta taagagtttt tcctcttatt tcacttttta aaaaaaatta     4920

aagtaggtgg ggaaaaaaat aaagctttac acagaattta tatgtgggta agtgtttcat     4980

ggaaatttct aatcttaacg aagctaagtg gagctcactc gtatccaaaa gtataacagg     5040

tgcagaagcc acaagtctga gaaccttgac gacagttcca tcgtcctgcc atttgatttt     5100

tcagtctgcg tttcatcact gtgtagctat tgtaaatgtg aatagaaaaa aacaggtcat     5160

tgcctatttt tgaagaacgc gttggtgttc gagtccacta gacacactcg ctccacacag     5220

ccttcaccgt agactctgta gtggacacag atatagcata aatgaaattg ttaaattatt     5280

tcattgtagt taattcccac tataggaatg ctttatcata gtgaagtttc ttttgagaag     5340

aaacggaact ccttgaggct tctctttggg atgtatatga gcgtgtacat attattctat     5400

gtgtttataa tataatattt tcccaaa                                         5427


<210> 1130
<211> 4050
<212> DNA
<213> Homo sapiens

<400> 1130
gtgccccccg cgccccgctc cggcagctcc acgctcgcgc ccgccatgcc ggagcagttc       60

agcgtcgccg agttcctggc cgtcaccgcg gaggacctca gctccccggc tggggccgcc      120

gccttcgccg ccaagatgcc ccggtaccga ggggcggcgc tggcgcggga ggagatcttg      180

gaaggagacc aagccatcct gcagagaata aagaaggctg tgcgggcaat ccatagctcc      240

ggccttggcc atgtggagaa tgaagagcag taccgagagg ccgtggaatc cttaggcaac      300

agccacctgt cccagaacag ccatgagctg tccacaggct tcctaaactt ggccgtgttc      360

acccgcgagg ttgctgcgct cttcaagaac ctgattcaga acttgaacaa cattgtctct      420

ttccccctgg acagtctgat gaaggggcag ctgagggacg gtcgacagga ttccaaaaaa      480

cagctggaga aggcatggaa ggactatgaa gccaaaatgg ccaagctgga gaaggagcgc      540

gatcgggcca gggtgacagg agggatccct ggggaggtgg cccaggacat gcagagagag      600

cggcgcatct tccagctgca catgtgtgag tatctgctca aagccgggga gagccagatg      660

aagcaaggtc ctgacttcct tcagagcctc atcaagttct tccacgccca gcacaacttt      720

ttccaagatg gctggaaggc tgcccagagc ctgttcccct tcatcgagaa gctggcggcc      780

tcagtacatg cactccatca ggcccaggag gacgagctac agaagctgac ccagctccgg      840

gactccctcc gagggacact gcagcttgag agcagagagg aacacctgag ccggaagaac      900

tcaggatgtg gctatagcat ccaccagcac caaggcaaca agcagtttgg gacggagaaa      960

gtgggctttc tatacaagaa aagtgacgga attcgaagag tctggcagaa aaggaagtgt     1020

ggagtcaagt atggctgcct gaccatctca cacagcacga taaaccggcc cccggtgaag     1080

ctgaccctgc tgacgtgcca agtgaggcca aaccctgagg agaaaaagtg cttcgacctg     1140

gtgacccaca accggacgta ccactttcag gcagaggacg agcacgagtg tgaggcgtgg     1200

gtgtcagtgt tgcagaacag caaggacgaa gccctgagca gcgccttcct cggggagccc     1260

agcgctggcc cggggtcctg ggggtccgcc ggccatgatg gggagccgca cgacctcaca     1320

aagctgctca tcgcggaggt gaagagcagg cctgggaata gccagtgctg cgactgcggg     1380

gctgcagacc ccacgtggct cagcaccaac ctgggcgtgc tcacctgcat ccagtgctcg     1440

ggcgtccacc gcgaactggg cgtgcgcttt tcgcgcatgc agtcactcac cttggacctg     1500

ctgggcccct ccgagttgtt gctggccttg aacatgggaa acacgagctt caatgaggtc     1560

atggaggccc agctaccctc acacggcggc cctaaaccct cagctgagag tgacatgggc     1620

acccgcaggg actacattat ggccaagtat gtggagcata ggtttgcacg ccggtgcaca     1680

cctgagcctc agcgactctg gacagccatt tgcaacaggg acctcctgtc ggtactggag     1740

gcctttgcca atgggcagga ctttggacag ccgctgccag ggcctgatgc acaggcacct     1800

gaagaactcg tcttgcattt ggctgtcaaa gtcgccaacc aggcttccct gcctctggtg     1860

gatttcatca tccagaacgg tggtcacctg gatgccaagg ctgctgacgg gaacacggct     1920

ctgcactacg cagcactcta caaccagccc gactgcctca agctgctgct gaaggggaga     1980

gctttggttg gcacagtaaa tgaagcaggc gagacagctc tggacatagc caggaagaag     2040

caccacaagg agtgtgagga gctgctggag caggcccagg cggggacctt tgccttccct     2100

ctacatgtgg actactcctg ggtaatttcc acagagcctg gctctgacag tgaggaggat     2160

gaggaagaga agcgctgctt gctgaagctc ccggcccagg ctcactgggc cagtgggagg     2220

ctggacatca gcaacaagac ctatgagact gtcgccagcc tgggagcagc cacccctcag     2280

ggcgagagtg aggactgtcc cccgcccttg ccagtcaaaa actcttctcg gactttggtc     2340

caagggtgtg caagacatgc cagtggagat cgttctgaag tctccagcct gagttcagag     2400

gcccctgaga cccctgagag cctgggcagt ccagcctcct cctccagtct gatgagcccc     2460

ttggaacctg gggatcccag ccaagcccca cccaactctg aagagggcct ccgagagccc     2520

ccaggcacct ccagacccag cctgacatcc gggaccaccc cttcggagat gtacctcccc     2580

gtcagattca gctccgagag cactcgctcc tatcggcggg gggcgcggag ccctgaagat     2640

ggtccctcag ccaggcagcc tctgcccaga aggaacgtgc cggttggcat cactgaagga     2700

gatggctcaa ggactgggag tctcccagca agttctgtgc aacttttgca agactagctc     2760

cttgctggcc cccacatgcc ccatgctagg ccccaatgtt cagagctggg acttgagctc     2820

acaaaactgg ggagctgaga catttgttct cttggatctc actctctctg tcccttgtgc     2880

ctctgtagct ggccttcttc ctgccacagg ccatgcctct accaaggaca catggccttt     2940

ccctgttagg actgatggcg gttctttcct atctcattac ccgctagggg cctgggagcc     3000

ctgtggctgg atctgagtgc tcctgagctg gcttcagctg cagaactctc agtccctcat     3060

cagatcgaga ctctatttcc cccgtcagtc tgggggcttc acaagggcag gagagccctc     3120

catcactgac ttccagatca gggaccctgc caagtaggga ctgtcttctc agccagccat     3180

ttattagtct aatattcctt cactaaattc caactctatg tctggacctg tgttaggcac     3240

ttcagatacc acacgagtaa gacaagggcc ctgcaggggt ggtcctttgg tggaaagctg     3300

gtcttaaggg ttgggcttgg gaataggcag ggtcagattc cagggcatgg ctctggactc     3360

agctggttta tacctatatg accattacaa ttgtctacag atcacatcca ttctggctgg     3420

tcaacatgca tgctgtactg gctgttaaat aaaaatattc tgaatgtcac tccttttgag     3480

ggacagcaca gccttcccta ggcattctcc tatattcccc agccaaattg tagagtcaga     3540

tgcacccaca tttgcctgtg tccttgattt agcaggaagg aaaggaatag tcagggttga     3600

tggatgccca cttctcttct ctttctcttg gtcaactcag gagcctttta gtctgaggga     3660

atggagaggc aaagaaagaa gggagagtaa tagaattggg agggcagaga cttaagggtt     3720

ctgcttccca gccctagaaa ttctatcatt gctcagcccc aatgagaaag cagatacacc     3780

taagccatca tcaaccacta acatctcaac ttgccagttg ctgggtgctg ggccctggca     3840

ggaatgggcc aagccaagca ggggagacta gagagcacca atggccaaca cagctgcctg     3900

gctggggagg ctgtgctgtt tcccctggag acctgactgg tctgtggttc ccacaggaac     3960

agggttgtct tttgagcccc cagtgtctgg tttcattcat ctcagacttg ttatttcact     4020

catctctaat aaaggattgg ggggtcagtt                                      4050


<210> 1131
<211> 1470
<212> DNA
<213> Homo sapiens

<400> 1131
cgcccaccca tccggggcaa gagccgcgcc gcaggagagg caggctggac cgggggctcc       60

ccgggcccgc gacccccgcc gtgaccccgc agcccccagc tcgcccccaa gatgatgaag      120

aggcagctgc accgcatgcg gcagctggcc cagacgggca gcttgggacg caccccggag      180

accgctgagt tcctgggtga ggacctgctg caggtagaac agcggctgga gccggccaag      240

cgggcagccc acaacatcca caagcggctg caggcctgtc tgcagggcca gagcggggca      300

gacatggaca agcgggtgaa gaagcttccc ctcatggctc tgtccaccac gatggctgag      360

agcttcaagg agctggaccc tgattccagc atggggaagg ccttggagat gagctgtgcc      420

atccagaatc agctggcccg catcctggcc gagtttgaga tgaccctgga gagggacgtc      480

ctgcagccac tcagcaggct gagtgaggag gagctgccag ccatcctcaa acacaagaaa      540

agcctccaga agctcgtgtc cgactggaac acactcaaga gcaggctcag tcaggcaacc      600

aagaattcag gcagcagtca aggcctagga ggcagcccgg gtagtcacag ccatacgacc      660

atggccaaca aggtggagac gctgaaggag gaggaggagg agctgaagag gaaagtggag      720

caatgcaggg acgagtactt ggctgacctg taccactttg ttaccaagga ggactcctat      780

gccaactact tcattcgtct cctggagatt caggccgatt accatcgcag gtcactgagc      840

tcgctggaca cagccctggc tgagctgagg gagaaccacg gccaagcaga ccactcccct      900

tcgatgacag ccacccactt ccccagggtg tatggggtgt cgctggcaac ccacctgcaa      960

gagctgggcc gggagattgc cctgcccatc gaggcctgcg tcatgatgct gctttctgag     1020

ggcatgaagg aagagggtct cttccgtctg gctgctgggg cctcggtgct gaagcgtctc     1080

aagcagacaa tggcctcgga cccccacagc ctggaggagt tctgctccga cccgcacgct     1140

gtggcaggtg ccctcaagtc ctatctgcgg gagctgccag agcctctgat gaccttcgac     1200

ctctatgatg actggatgag ggcagccagc ctgaaggagc caggggcccg gctgcaggcc     1260

ctccaagagg tgtgcagccg cctacccccc gagaacctca gcaacctcag gtacctgatg     1320

aagttcctgg cacggctggc cgaggagcag gaggtgaaca agatgacacc cagcaacatc     1380

gccatagtcc tgggacccaa cttgctgtgg ccacctgaga aagaaggcac agagccagcc     1440

agagagttgg ggtcacaaac cctttgctga                                      1470


<210> 1132
<211> 2274
<212> DNA
<213> Homo sapiens

<400> 1132
cgcgcggtga ccgttggcgc cgaggggagg aggcagccgc cgccgccgcc gccgccgccg       60

ccgccgccgc cgccgccgtt gcgcagatcc gggccgcggc tgtggggagg gcgacggagc      120

gggtgacctt ccggaggcgg gagcgagcga ggaggcccgg gagcgccgag cgtcgccgcc      180

gccgccgcca tgaacaactc gggcgccgac gagatcggga agctcttcgt gggcggtctt      240

gactggagca cgacccaaga gactctgcgc agctactttt cccaatatgg agaagtcgta      300

gattgtgtta tcatgaaaga taaaaccacc aaccagtctc gaggctttgg gtttgtcaaa      360

tttaaagacc caaactgtgt ggggacggtg ctggccagca gaccgcacac gctagatggc      420

cgaaacatcg accccaagcc atgcacaccc cgggggatgc agccggagag aacacggccg      480

aaggaaggat ggcagaaagg acccaggagc gataacagta aatcaaataa gatatttgtc      540

ggtggaattc ctcacaattg tggtgagaca gagctcaggg aatacttcaa gaagttcgga      600

gtggtcacgg aggtagtcat gatctatgac gccgagaagc agaggccccg aggttttgga      660

tttattactt tcgaggacga acaatcagtg gaccaggctg tcaacatgca ttttcacgac      720

atcatgggca aaaaagtgga agttaaacga gctgagcctc gggacagcaa gagccaagcg      780

ccgggacagc caggtgccag ccagtggggg agccgggttg tgcccaacgc tgccaatggc      840

tgggcaggcc agcccccgcc cacgtggcag caaggatatg gcccgcaagg aatgtgggtg      900

ccggcaggac aggcgattgg tggctatgga ccgccccctg caggaagagg agcccccccg      960

ccacccccac cgttcacctc ctacatcgtg tccacccctc ctggaggctt tccccctccc     1020

cagggcttcc ctcagggcta cggtgccccg ccacagttca gttttggcta cgggcctcca     1080

cctccaccgc cagatcagtt tgcccctccg ggggttcctc ctccaccagc cactcccggg     1140

gcagcacctc tggctttccc accgcctccg tctcaggctg ccccggacat gagcaagccc     1200

ccgacagctc agccagactt cccctatggt cagtatggcc tgggttccta ttctccagcc     1260

ccgccgggct gcggcccaca ctttgtttac agtcttatgg tcaggctgag cagtgatgtg     1320

gcctagcagg ttacgggcag gacttgagtg gcttcggaca gggcttctca gaccccagcc     1380

agcagcctcc ttcctacggg ggtccctccg tgccagggtc ggggggcccc cccgccggcg     1440

gcagcggctt tggacgaggg cagaaccaca acgtgcaagg gttccacccc taccgacgct     1500

agcccgcggc gccgcgacgt ctgcacggcc cagacccagg attccaaact tgtgaactcg     1560

tgacaatcac aaacttggcg gcaaagtggc gactcaacct tggggggggg ggcgggggga     1620

gggcgcgagg cttttggagc ggctgtgggt gtcgtctgga ctgaggtttt taaatatttc     1680

tttctctaac ccatcagcac aataaaaaaa agtcactggt tcaacaacag ggtttaaaaa     1740

aaatgtcttc agctttaatt caaaacttca ggtttctttt tcttcctttt ttttggaaat     1800

tattttcctg agccttttgt tttacggtat attgtaaact tttatgttaa agaaaaaata     1860

tacatttaca aattgtgaga tttttaagag aaattttcta cgatgtatac tggcttattt     1920

tttaatttaa aacggggttt ccgtcggcac tggtggaggg ggtgcgctgt tagtcccctc     1980

gctcctggct ttgggggttg ggacttggtg gtccagaaac tctgggagct tctagaagaa     2040

atctactgag tgtatttctg ttttttgttt aattccttgc ttttgtcgac tgacctgctt     2100

ggtagtgtct gaggtgaact gtgggggttg cgcacagcca gccgcgtgga tcccacgcag     2160

cgctgaaccg aaccgagtag gaagcctttc tccccaggca cgtggcttca gggcgtttcc     2220

cattgaccag tttgaccctg gtttgaataa agagaagtgc gtttggatta gaaa           2274


<210> 1133
<211> 2715
<212> DNA
<213> Homo sapiens

<400> 1133
aggttgttac catggagatg gctaacagct agagcaggct gtcctcggag ggagacattc       60

catctccaga cacccagaga cgctccagaa tggaggtcct gagggagaag gtggaggagg      120

aggaggaggc cgagcgggag gaggcggccg agtgggctga atgggcgagg atggagaaaa      180

tgatgaggcc agttgaggtg cggaaggagg aaatcacctt aaagcaggag acgctcagag      240

acctggagaa gaagctgtca gagatccaga tcactgtctc agcggagctc ccggccttta      300

ccaaggacac tattgacatc tccaagctgc ccatttccta caaaaccaac acacccaagg      360

aggaacacct gctgcaggtg gcagacaact tctcccgcca gtacagccat ctgtgcccgg      420

accgcgtgcc cctcttcctg caccccctga acgagtgtga agtgcccaag ttcgtgagca      480

caaccctccg gcccacactg atgccctacc ccgagctcta caactgggac agctgtgccc      540

agtttgtctc cgacttcctc accatggtgc ccctgcctga ccctctcaag ccgaccatca      600

agaaggagga aaaggtgctg cctaagaagt ataccatcaa accccccagg gacctgtgca      660

gcaggtttga gcaggagcaa gaggtgaaga agcagcagga gatcagagcc caggagaaga      720

agcggctgag ggaggaggag gagcgcctca tggaagcgga gaaggcaaag ccggatgccc      780

tgcacggcct gcgggtgcac tcctgggtcc ttgtgctatc ggggaagcgc gaggtgcctg      840

agaacttctt catcgaccca ttcacaggac atagctacag cacccaggat gagcacttcc      900

tgggcatcga aagcctgtgg aaccacaaga actactggat caacatgcag gattgctgga      960

actgctgcaa ggacttgatc tttgacctgg gtgaccctgt gagatgggag tacatgctcc     1020

tggggactga taagtctcag ctgtccttga ctgaagaaga cgacagtggg ataaacgatg     1080

aggatgatgt ggaaaatctg ggcaaggagg atgaggataa gagcttcgac atgccccact     1140

cgtgggtgga gcagattgag atctccccgg aagcatttga gacccgctgc ccgaacggga     1200

agaaggtgat tcagtacaag agggcaaagc tggagaagtg ggccccgtac ctcaatagca     1260

atggccttgt gagccgcctc accacctatg aggacttgca gtgtaccaat attttggaga     1320

taaaggagtg gtaccagaac cgggaagaca tgctggagct gaaacacata aacaagacca     1380

cagacctgaa gacagactac ttcaagcctg gccaccccca ggctctgcgc gtgcactcgt     1440

acaagtccat gcaacctgag atggaccgtg tcattgagtt ttatgaaacg gcccgtgtgg     1500

atggcctgat gaagcgggag gagacaccca ggacaatgac agagtactat caaggacgcc     1560

cagacttcct ctcctaccgc catgccagct tcggaccccg agtcaagaag ctcactctga     1620

gcagtgcaga gtcaaacccc cggcccattg tgaaaatcac agagcggttc ttccgcaacc     1680

cagcgaagcc cgcggaggag gacgtggcag agcgcgtgtt tctggtcgcg gaggagcgca     1740

tccagctgcg ctaccactgc cgtgaggacc acatcacggc ctccaagcgc gagttcctgc     1800

ggcgcaccga ggtggacagc aaaggcaaca agatcatcat gacgcccgac atgtgcatca     1860

gcttcgaggt ggagcccatg gagcacacca agaagctgct ctaccagtac gaggccatga     1920

tgcacctgaa gagggaggag aagctgtcca gacatcaggt ctgggagtca gagctggagg     1980

tgctggagat tctgaagctt cgagaggaag aggaggcggc gcacacactg accatctcca     2040

tctatgacac caagcggaat gagaagagca aggaatatcg ggaggccatg gagcgcatga     2100

tgcacgaaga gcacctgcgg caggtggaga cccagctgga ctacctggcc ccattcctgg     2160

cccagctccc gccaggagag aaactaacat gctggcaggc ggtgcgcctc aaggatgagt     2220

gcctcagcga cttcaagcag cggctcatca acaaggccaa cctcatccag gcccgctttg     2280

agaaggagac ccaggagctg caaaagaagc agcagtggta ccaggagaac caggtgacgc     2340

tgacacccga ggatgaagac ctgtacctga gttactgctc tcaggccatg ttccgcatcc     2400

gcatcctgga gcagcgcctc aatcgacaca aggaactggc cccactgaag tacctggctc     2460

tggaggaaaa gctctacaag gacccacgcc tgggggagct ccagaaaata ttcgcttgat     2520

gtccctcctg gggcctcagc cagagctgcc agagaaagga aacctcttcc cgcagcctgg     2580

ctcctgtgtt ccctctatcc agccaatgcc tgtttacaca gacacctggc ctcactgcca     2640

gcccacctcc cctacagccc tgtttgttcc tgcttctcat gattttcctg taaataaaca     2700

cactcttaat ttgcc                                                      2715


<210> 1134
<211> 1193
<212> DNA
<213> Homo sapiens

<400> 1134
cagtcagatc catcatgtgg ccactgacag cccttctgct cctggttcca agcagtgggc       60

aagctgctac tctggagaag cccatattgt ctctacatcc accttggacc accatcttca      120

aaggggagcg ggtaactttg aagtgtgatg gataccaccc actgctcctg gagctccagc      180

ccatcagcac tctctggtat ttgggccacc tacttctgcc ctctcacaag aagagcattg      240

aggtgcagac accaggggtg tatcgatgcc agacacgggg agcacccgtc agtgacccca      300

tccacctctc tgtatccaat gattggctga ttctgcaagt gccctatgcg ccagtgttcg      360

agggtgagcc gctagtcctg cgctgccgcg gctggtacga caaggtggtc tacaagcttc      420

actactacca cgacggccag gccgtgcgct acttccactc cagcgccaac tacactgtgt      480

tacaggcgcg tgccagcgac agcgggcgct accagtgctc gggcaccatg cgcatcccgg      540

tggagagcgc gcccatgttc tccgctaagg tggctgtgac agtgcaagaa gcgcgacacg      600

ccgctgcagt tcgcgtttta caagtacagc cgcgcggtgc gccgcttcga ctggggcgcc      660

gagtacacag tcccggagcc cgaggtcgag gagctcgaat cgtactggtg cgaggcggct      720

accgccaccc gcagtgtccg gaaacgcagt ccgtggctgc agctcccggg gccgggttct      780

cccctggacc cggcctccac caccgcccca gctccatggg ccgcagcctt ggctcctggt      840

aataggccgc tttccttcag aaagcccccg gtgtccagat cggtcccgtt ggtcacctcc      900

gtccggaaca ccacctccac cgggctgcag ttcccggcga gcggcgcccc gactgcgggg      960

ccacccgcct gcgctccgcc gacgcccttg gaacaatcgg ctggagccct gaaacccgac     1020

gtggaccttc tgctccgaga aatgcagctg ctcaaaggcc ttctgagccg ggtggtcctg     1080

gaattaaagg agccacaggc cctccgggag ctcaggggaa cgcccgagac ccccacctct     1140

cactttgctg tgagcccggg aaccccagag accactcctg tggagagctg agg            1193


<210> 1135
<211> 1439
<212> DNA
<213> Homo sapiens

<400> 1135
gcggcttccg gtcccggctc agcctccgac ccaggtggtc tggagcctgc cgggagagtg       60

gtggcatctg agaggctggt cgtggactgt ggttggggga ggtgggagct gttttaaccg      120

tgtgccccct ctcctgtgcc ggcgtgggca tcccccgggg cagtggaacg cgggcgctcc      180

tccagcttcc gagtccagcc agcctgggcg cggggcgccg cccccgagac acccgaggag      240

tccgttcctc cctggttacg tggactgtgg agctggtctc ttgtggctca gcgccgtgcg      300

gaggttgaag cgtacctgcg gaggtcgcac cagggcgtga ggaggaggag gaagggcatg      360

agccgagctt gaggaatccg tgctccaaac tctacactca agggtggccc ttgggtaggg      420

tgaagatccc ctgtctttat cctagttcca caccttggtg tgggttactg ggtgcaggat      480

gaactgtcgc tcggaggtgc tggaggtgtc ggtggagggg cggcaggtgg aggaggccat      540

gctggctgtg ctgcacacgg tgcttctgca ccgcagcaca ggcaagttcc actacaagaa      600

ggagggcacc tactccattg gcaccgtggg cacccaggat gttgactgtg acttcatcga      660

cttcacttat gtgcgtgtct cttctgagga actggatcgt gccctgcgca aggttgttgg      720

ggagttcaag gatgcactgc gcaactctgg tggcgatggg ctggggcaga tgtccttgga      780

gttctaccag aagaagaagt ctcgctggcc attctcagac gagtgcatcc catgggaagt      840

gtggacggtc aaggtgcatg tggtagccct ggccacggag caggagcggc agatctgccg      900

ggagaaggtg ggtgagaaac tctgcgagaa gatcatcaac atcgtggagg tgatgaatcg      960

gcatgagtac ttgcccaaga tgcccacaca gtcggaggtg gataacgtgt ttgacacagg     1020

cttgcgggac gtgcagccct acctgtacaa gatctccttc cagatcactg atgccctggg     1080

cacctcagtc accaccacca tgcgcaggct catcaaagac acccttgccc tctgagcgtc     1140

gctggatctc tgggagctcc ttgatggctc ccagaccttg gcttttggga attgcacttt     1200

tgggcctttg ggctctggaa cctgctctgg gtcattggtg agacttggaa ggggcagccc     1260

ccgctggctt cttggttttg tggttgccag cctcaggtca tccttttaat ctttgctgac     1320

ggttcagtcc tgcctctact gtctctccat agccctggtg gggtccccct tctttctcca     1380

ctgtacagaa gagccaccac tgggatgggg aataaagttg agaacatgag tttgggctg      1439


<210> 1136
<211> 2536
<212> DNA
<213> Homo sapiens

<400> 1136
ctgctgccgg cccctcttcc ccgacggcta ataataaacc cgggttcctg tttcccggcc       60

gcggccactc cagattcggg gctgaggggc tcactctgca accaaggcac gtgcattctg      120

gtcatcccac gcggggagcg cgcgcaaggc ccgcccagcc cccacatgcc agccccaccc      180

tccagtcggt ccggacgccg acgccttttt gaccctcgct gtgcccggcc ctcctcatct      240

ggcctgccca gggcttggtg ctggcggggt ccagctgctc caatccctcc tcctctgctc      300

tgccctgccc tgccctggcc tgccccggcg ccctccctca gcccgggtat caggcgagag      360

gcggagctgg cccggcgcgc cccgcccccg ctgtagaaag ggccgggcga gtgttactcg      420

cggtcatccc ggcctgggcc ttttatctcg gtgctgccgg gggaggcggg aggaggagac      480

accaggggtg gccctgagcg ccggcgacac ctttcctgga ctataaattg agcacctggg      540

atgggtaggg ggccaacgca gtcaccgccg tccgcagtca cagtccagcc actgaccgca      600

gcagcgccct tgcgtagcag ccgcttgcag cgagaacact gaattgccaa cgagcaggag      660

agtctcaagg cgcaagagga ggccagggct cgacccacag agcaccctca gccatcgcga      720

gtttccgggc gccaaagcca ggagaagccg cccatcccgc agggccggtc tgccagcgag      780

acgagagttg gcgagggcgg aggagtgccg ggaatcccgc cacaccggct atagccaggc      840

ccccagcgcg ggccttggag agcgcgtgaa ggcgggcatc cccttgaccc ggccgaccat      900

ccccgtgccc ctgcgtccct gcgctccaac gtccgcgcgg ccaccatgat gcaaatctgc      960

gacacctaca accagaagca ctcgctcttt aacgccatga atcgcttcat tggcgccgtg     1020

aacaacatgg accagacggt gatggtgccc agcttgctgc gcgacgtgcc cctggctgac     1080

cccgggttag acaacgatgt tggcgtggag gtaggcggca gtggcggctg cctggaggag     1140

cgcacgcccc cagtccccga ctcgggaagc gccaatggca gctttttcgc gccctctcgg     1200

gacatgtaca gccactacgt gcttctcaag tccatccgca acgacatcga gtggggggtc     1260

ctgcaccagc cgcctccacc ggctgggagc gaggagggca gtgcctggaa gtccaaggac     1320

atcctggtgg acctgggcca cttggagggt gcggacgccg gcgaagaaga cctggaacag     1380

cagttccact accacctgcg cgggctgcac actgtgctct cgaaactcac gcgcaaagcc     1440

aacatcctca ctaacagata caagcaggag atcggcttcg gcaattgggg ccactgaggc     1500

gtggcgcccg tggctgccca gcaccttctt cgacccatct caccctctct cattcctcaa     1560

agcttttttt ttttttcctg gctggggggc gggaagggca gactgcaaac tggggggctg     1620

cgtacgtgca ggaggcgcgg tggggctgcg tggaggaggg ggccacgtgt gagagagaag     1680

aaaatggtgg ccggagatgg gagggcccaa ggaacctcct gggagggggc ctgcattcta     1740

tgttggtggg aatgggactg ggctgacgcc ctgcattcag cctgtgcctt tcctggggtt     1800

tcttttctgt tcttttcgga ggagagggcc cgagaagggg ccataccagg gcgcggcgct     1860

gggttgccac acttgggaaa gcagcccgga gctgggtgct ggggaaggcg gggcgcgtag     1920

cctcccgccg ccctgcggtt gggccggtgg aggcccaggc gttgctagga ttgcatcagt     1980

tttcctgttt gcactatttc tttttgtaac attggccctg tgtgaagtat ttcgaatctc     2040

ctccttgctc tgaaacttca gcgattccat tgtgataagc gcacaaacag cactgtctgt     2100

cggtaatcgg tactacttta ttaatgattt tctgttacac tgtatagtag tcctatggca     2160

cccccacccc atccctttcg tgccactccc gtccccaccc ccaccccagt gtgtataagc     2220

tggcatttcg ccagcttgta cgtagcttgc cactcagtga aaataataac attattatga     2280

gaaagtggac ttaaccgaaa tggaaccaac tgacattcta tcgtgttgta catagaatga     2340

tgaagggttc cactgttgtt gtatgtctta aatttattta aaactttttt taatccagat     2400

gtagactata ttctaaaaaa taaaaaagca aatgtgtcaa ctaaattgga caagcgtctg     2460

gtcctcatta atctgccaat gaatggtttc gtcattaaat aaaaatcaat ttaattgatt     2520

tactagcaaa agtaaa                                                     2536


<210> 1137
<211> 821
<212> DNA
<213> Homo sapiens

<400> 1137
attctcatcc ctgtgctcag agctctcaag cacccacgat ggccttctca ggccgagcgc       60

gcccctgcat tatcccagag aacgaagaaa tcccccgagc agcccttaac actgtccacg      120

aggccaatgg gaccgaggac gagagggctg tttccaaact gcagcgcagg cacagtgacg      180

tgaaagtcta caaggactct tctatgagtt tgaaggaaga aagtactgtg aacatgactt      240

tcagatgctc tttgcccctt gctgtcatca gtgtggtgaa ttcatcattg gccgagttat      300

caaagccatg aataacagct ggcatccgga gtgcttccgc tgtgacctct gccaggaagt      360

tctggcagat atcgggtttg tcaagaatgc tgggagacac ctgtgtcgcc cctgtcataa      420

tcgtgagaaa gccagaggcc ttgggaaata catctgccag aaatgccatg ctatcatcga      480

tgagcagcct ctgatattca agaacgaccc ctaccatcca gaccatttca actgcgccaa      540

ctgcggacag gaaggatctg actgccgatg cacaggagct gaaaggggag ctatactgcc      600

tgccatgcca tgataaaatg ggggtcccca tctgtggcgc ttgccgacgg cccatcgaag      660

ggcgtgtggt gaacgccatg ggcaagcagt ggcatgtgga gcattttgtt tgtgccaagt      720

gtgagaaacc ctttcttgga catcgccatt atgagaggaa aggcctggcg tattgtgaaa      780

ctcactataa ccagctattt ggtgatgttt gcttccactg c                          821


<210> 1138
<211> 2600
<212> DNA
<213> Homo sapiens

<400> 1138
gaactgggcc aagcgccccc ggaggcgcta agcttgcgcc ctgaggcggt ttccgttccc       60

ggacgtttgg actctgtcct ggagaagggg aaggaaaaag taagacgtag aagtacactg      120

agacttcgtc acacataaaa caagcacgac aaagaaagag ggcgcgaagg gactcctgga      180

agaaattgag tctacattta agatcaccct aaaagtagtg acggcctctt cattactcca      240

aaccccagat ttaagtcggt aggacgtctt cgcgttgact tgtggggaat gtagtttcga      300

tgctgccggc gcgttttgtt tgcgacagaa actacaaccc ccaggggcca ccgcgacgtt      360

gcctgtgggt gcccgcgaac caacggttag cggtggcagg ggctgactga gagcgtctgc      420

ttgtgcctgg tacctagtac aaacttaata aatgtgtgac gcaagaataa aggaatgaat      480

gaatggaaga atgatataat gccacagaac tttcaaagat gggactgtct agttgcaaaa      540

acaagctcag ggatcccact gattctactt tacgataatg gattctgaat taatgcatag      600

tatagtagga agctatcata aacctccaga aagagtattt gttccctcat tcacccagaa      660

tgaaccatct cagaattgcc atcctgcaaa cttagaagtt acctctccta agatacttca      720

tagcccaaat agccaagaga agcaactaga atatacaaag agaatggttc tcaacgtaga      780

gcgagaaaag aacatgatcc tagaacaaca ggcccagctt cagagggaaa aagaacaaga      840

tcagatgaag ctgtatgcaa aacttgaaaa gcttgatgtc ttagaaaaag agtgtttcag      900

acttacaaca actcagaaaa ctgctgagga caagattaaa catttagaag aaaaacttaa      960

ggaagaagaa catcagcgta agctatttca agacaaagct tctgagcttc aaactggact     1020

tgaaatcagt aaaattataa tgtcttcagt ttcaaatcta aagcactcca aggaaaagaa     1080

gaaatcttca aagaaaacta aatgtataaa gagacgacca ccttggcaaa tttgttcaaa     1140

gtttggagca ctgccttttg tggctgaaaa gccttctaga acaacttcct ggtgtaaagc     1200

tattcctcct gactcagaaa agtccatttc catttgtgac aatttatctg aacttttgat     1260

ggcaatgcaa gatgagctgg accaaatgag catggagcac caagaactac tgaaacaaat     1320

gaaggaaact gaaagtcatt cagtctgtga cgacatagaa tgtgaactag agtgtttact     1380

caagaaaatg gaaattaaag gagaacaaat ctccaaactg aagaagcatc aagacagtgt     1440

ctgtaaactg cagcaaaaag ttcaaaactc aaagatgagt gaagcttcag gtattcagca     1500

agaagacagc taccctaaag gatcaaagaa cataaaaaat agccccagaa aatgtttgac     1560

tgacactaac ctttttcaga aaaacagcag ctttcatcca atacgagttc ataatcttca     1620

aatgaaattg agaagagatg atatcatgtg ggaacagtaa caaaacagca aaactgtcac     1680

cttaatgaac tttgtcagtg agaccttgaa ttgtctaaag tggttttaat ttaatataac     1740

tttgtgacat tttgaatcat gtttctagtt tctataaaac atgaagttgc agtatttaaa     1800

aattaatgcc taatgacctg gtgggttcca aataataaat taattgcttt tttatttttc     1860

ttattgattg aagcccgtaa cctcatcttg tcttagaaac attgttggct ttgcagatat     1920

cttaagctaa atttaagaaa ttgtactaga ttgacaatat tcaaaattga gttaaatcca     1980

agctacaagt accattcatt ccacttttca tttagtaggt ttggaacctt aaaaaccaat     2040

gttcaatgaa cagagttcag aaagatcatt tagctttcct ggtgccttct ttctattttg     2100

ttttagagct gtgaaatgtt tttctctttt ggaaaaggaa aaacttaata gttacacagt     2160

tttgtgaaga agcctttaat ccaagtttta tgagacagta ggaacctata gctacttaat     2220

ttttaggaga cagtaattca gttgcagaag ctttcctctg ctattcccat tctcttttac     2280

aaaactagtt ttttttaaaa aatcaatgat caattttatc ttactacttt ataacttttg     2340

ctgactttta ttctttgcat tgtatgtaat gtccatcagt ataaattgag actgtgaatt     2400

tctaggaccc acaaaagtgg tatttttttt ttgtacaaga aagtatagag gaagaggaag     2460

ctgggcatta aattacctca tccagcagaa attcacggta gtatggtata tttttatttt     2520

ttatatttta aaatcaataa tgtcaaatgt cattgtgtat gcatgcttta taataaattt     2580

acacttgatc atttttctgg                                                 2600


<210> 1139
<211> 2221
<212> DNA
<213> Homo sapiens

<400> 1139
cgccgcagcg cgcgcccttc ccctcctcac cgctacctgc tccggttccg gcgctcggcc       60

gctccgttgc cctcgggcgc cttggttgcg gccctccgct gaggagccat cggaccaggc      120

cgccgcggag ccgggccgga cgcgggcgcc aggcccgggg acgaacgccg taacagggag      180

cgcgaggcag gcacggcgca gggacgcgag tgcgacgcgc tcggccatcg gcccctgggc      240

tggcggccag gcccgagcaa tcggcggccg agcggggcgg ggctcagagc ggaggcggcg      300

gccgcgaggg cggggcggcc gggcctggct gcgcccccgg acctcgcggg accgcggcgg      360

cgcaggaaga agtccccaag gagacttcgc cataggagtt cacaggaaat attgaaatgt      420

caggttccac tccatttcag atgagattag ttcatttaga ccttaaagga gctccaccaa      480

aggtctcgta cctctcagag atttttcctc tgttccgtgc gctaggtgca aacggcctcc      540

tcattgagta tgaagacatg tttccctacg agggccctct gaggctgctg agggccaagt      600

acgcctacag cccctctgaa atcaaagaga tcttgcatct ggctggactc aatgagctgg      660

aggtgattcc cttggtgcag acatttggac acatggagtt tgtgctgaag cacacggcct      720

tcgcccacct gcgggaggtg ggctccttcc cctgcaccct gaacccccac gaggcagagt      780

ccctggcgct ggtgggcgcc atgattgacc aggtcctgga gctacaccca ggcgcccagc      840

ggctgcacat cgggtgtgat gaggtctatt acctcggaga gggggaggcc tcgcgccggt      900

ggctacagca agagcagaac agcacgggga agttgtgcct gtcacacatg cgggcggtgg      960

ccagcggcgt gaaggcccgg cgccccagcg tgacacccct ggtgtgggac gacatgctcc     1020

gagacctgcc tgaggaccag ctcgcagcgt ccggggtgcc gcagctggtg gagccggtgc     1080

tctgggacta cacggccgac ctggatgtgc acggcaaggt cctcctcatg cagaagtacc     1140

ggcggtgcgg ctttccgcag ctgtgggcag ccagtgcctt caagggtgcc acggggccca     1200

gccaggccgt gccccctgtt gagcaccacc tcaggaacca cgtgcagtgg ctgcaggtgg     1260

cgggcagcgg gcccacggac tcactgcagg gcatcatcct gaccggctgg cagaggtacg     1320

accactactc tgtgctgtgc gagctgctgc ccgcaggagt cccgtccctg gccgcctgcc     1380

tgcagttgct tctacgcgga ggatttgatg aagatgttaa agcgaaagtg gagaaccttc     1440

tcgggatttc cagcctggaa aaaacggacc ctgttaggca agcaccctgc agccctccct     1500

gtccccttct tcccctcccc ttcccccgcc cgtggagaca gctgttctca gcagggctct     1560

ccgcagggag ggggccggct ccttccctgg cagcaacatc cttgcccttg tcacacaagt     1620

cagcctccat ctgcgcagct ctgtggatgc gctgctggag ggcaacaggt atgtcactgg     1680

ctggttcagc ccctaccacc gccagcggaa gctcatccac ccggtcatgg ttcagcacat     1740

ccagcccgca gcgctcagcc tcctggcaca gtggagcacc ctcgtgcagg agctggaggc     1800

tgccctgcag ctggctttct acccggatgc cgtggaggag tggctggagg aaaacgtgca     1860

ccccagcctg cagcggctgc aagctctgct gcaggacctc agcgaggtgt ctgccccccc     1920

gctgccaccc accagccctg gcagggacgt tgctcaggac ccctgagggg agagctcatg     1980

ccagggggct cctgctggag gctggggggg ctctgcactg ccaaatggcc tgggcaatac     2040

gggcccacgt gggcgtcgtg ccctctggcc cagcagtgtc ttgcccacac tcagttcctg     2100

agggccctgg gcagcccctg ggggagagac tagaaaacac agaaggaagc agcacaggga     2160

gacccgcttt gtgatctgca tgtgtgacac tgattctttg gaaataaaga gtggaagctg     2220

c                                                                     2221


<210> 1140
<211> 5778
<212> DNA
<213> Homo sapiens

<400> 1140
gagttcattt gctcgcgtgc aggggaagtc tggagaaggc attgtttcaa ttattaaaag       60

tgtgggggca gtgggcggaa caaacgcgcc gactacagag gctggacgta agcttagcgg      120

tggcgcgcgt gcgcagcgcc ggcccgagtt gccaaaacaa aggggatttg gtgatggagg      180

ctttgttaga aggaatacaa aatcgagggc atggtggggg atttttgaca tcttgtgaag      240

cagaactaca ggagctcatg aaacagattg acataatggt ggctcataaa aaatctgaat      300

gggaaggacg tacacatgct ctagaaactt gcttgaaaat ccgtgaacag gaacttaaga      360

gtcttaggag tcagttggat gtgacacata aggaggttgg aatgttgcat cagcaggtag      420

aagaacatga aaaaatcaag caagagatga ccatggaata taagcaggag ttgaagaaac      480

tacatgaaga attatgcata ctgaagagaa gctatgaaaa gcttcagaaa aagcaaatga      540

gggaattcag aggaaatacc aaaaatcaca gggaagatcg gtctgaaatt gagaggttaa      600

ctgcaaaaat agaggaattc cgtcagaaat cgctggactg ggagaagcaa cgcttgattt      660

atcagcaaca ggtatcttca ctggaggcac aaaggaaggc tctggctgaa caatcagaga      720

taattcaggc tcagcttgtc aatcggaaac agaaattaga gtctgtggaa ctttctagcc      780

aatcagaaat tcaacactta agcagtaaac tggagcgggc taatgacact atctgtgcca      840

atgagttgga aatagagcgc ctcaccatga gggtcaatga cttggttgga accagtatga      900

ctgtcctaca ggagcagcag caaaaagaag aaaaattgag ggaatctgaa aaactattag      960

aggctctgca ggaagaaaag agagaattga aggcagctct tcagtctcaa gaaaatctca     1020

tacatgaggc cagaatacaa aaggagaagt tacaagaaaa agtaaaggca actaacactc     1080

aacatgctgt agaagctata aggccacggg aagaatctct ggcagaaaag aagtacacct     1140

ctcaagggca gggggactta gacagtgtgc tctcccagtt gaattttacc catactagtg     1200

aggaccttct gcaggcagag gtgacttgtc ttgaaggcag tttggaatct gtgagtgcaa     1260

cgtgtaaaca gctgagccaa gaactaatgg aaaaatatga agaactgaag aggatggaag     1320

cacataacaa tgaatacaaa gcagagatta agaagttgaa agaacagatt ttacagggtg     1380

aacaaagtta cagttctgca ctagaaggaa tgaagatgga aatctcccat ctaactcagg     1440

agttacatca gcgagatatc actattgctt ccaccaaagg ttcttcctca gacatggaaa     1500

agcgactcag agcagagatg caaaaggcag aagacaaagc agtagagcat aaggagattt     1560

tggatcagct ggagtcactc aaattagaaa atcgtcatct ttctgaaatg gtgatgaaat     1620

tggaattggg tttacatgag gcaaaagaga tttcactagc agacctccag gagaattata     1680

ttgaggcatt aaataaatta gtgtctgaaa atcaacaact acagaaagat ttgatgaata     1740

ccaaatctca gctggagatt tctactcaga tgtgcaaaaa acaaaatgac aggatcttta     1800

aaccaacaca cagcagaaca actgagttca agaatacaga gttcaagcca acccatggcc     1860

agcacagaca tgatggaata aagactgagc actacaaaac agatcttcat tctccaagag     1920

gacaagcgtc ggatagtata aaccccatgt ctagggtgct aagccccctg agtcctcaaa     1980

tcagcccttg cagctccacc aggtctttga cttcctactc tctatgtaaa actcattctt     2040

tgccttcagc gctagataca aatgaagcca atttttctga cactatgtct gagagtatga     2100

atgaccaaga agagtttata tcttcgtgtt ccttgcctgt atctcccctt ggttcaatag     2160

ctaccagatt tttggaagag gaggaactga ggtctcatca cattctagag cgcttggatg     2220

cccatattga agaactaaaa agagagagtg aaaagacagt gagacaattc acagccttaa     2280

agtagcctct taaaaaaatc actatcttgg aaataaaaat aaacaccaaa gagttactgt     2340

catctgaagt agcagctctt taaaaacatg aagagataaa attataaaaa tgatacatct     2400

aaagcagtgg tgaagaaagc tgaaaaactg atacttttga taggcatttt ctctgcactg     2460

gtttgtttaa aggacttctt ccagcaataa gttgaaagaa taaaccactt tgctagactt     2520

ttttctcata cgaatattta ttatcataaa gtgatactta ccttgctgac ttaaatgtga     2580

atagctatgt actaattgaa ataaggattt tatgatacat gttgaaaata aagtaactgc     2640

aggaactttc tttaggggaa atgtgtagaa gcatggattt aggggtcaaa catacctgga     2700

tcgatagact ggttttgcca cttaccagcc aacggggctt gttatttact gggctggtag     2760

cccctcctag ccaaggggct ggtagtgtgt aaagtcaggc tggtagtgaa taaggggggg     2820

gtgtgctaaa gaaccttatc aagcagtcct ctcttgctca acactcatgc agaggagaga     2880

ggcagggagg gcaagggact ggctgtcatg cacggtgccc atggaatatc cattggaaat     2940

aaatgttcat cgtctgcact gctgaggaca agtttagatg ggagacaaag atctggatgt     3000

tgatgtgccg caggcatttg aaacgatggg agttgataag atccaccagg gaggctgtgg     3060

agagagagag gagcaggagg ctgggtttgg ggccctgaaa gatgccagca tctgaggatc     3120

acaggaaata gatctagcaa aggaactaga atgtgcagtt acagatgaga aaggtcagtg     3180

tagtgtactt gccagctcaa gggtgtggcc tctgtgaacc ctctttctgt agtggatctt     3240

tcccatcagc gtaaaacatc ctgttatttc ccctttttaa ataaaacctc agtttttttt     3300

aatgcctctc ttttactgct ctgtatgttt gcttcccttc acccaaacac ttctggaaag     3360

agttgtctgc agtgactctt tccagttcct caccccgccc caccgtagtt ctcttcctaa     3420

ccctctccaa caccacttcc atccccagac tgctttcttg ctcttgagtt caccagtgac     3480

ctaatcagtg tctgagcatc attcagcaca gttggactct ctcttggctt ctgtgacctg     3540

gaacttctgg tttcctctct acctcatcct ccactccatc tcatggcttt tcctcttcta     3600

acctctaagt cagagggccc cctagagctc tgtcatgggt tttctccctc agcattctct     3660

tccctagaag tttccattcc attctcaagc tcttaatacc acctataggc cagtgaccct     3720

tacatttatt actaatcttg acctctcccc agagctgctg tcttagatac ctagctgctt     3780

atgcgatgtc ttcacttgga tatctgacaa acatcttgtt tccaagagag aactctttat     3840

tctccctctt gctaagattc catatcagga catagcatta tgtttgccag ttcctaggag     3900

ttacttataa ttccttcctt acccacatcc gcatatccag tcatttggga ggtcctgtca     3960

tttcttcccc cagaatctta tctcagaccc aaccgtttcc ctcctgcact tctaccacct     4020

gatccagact acttctctct caccctgatt ctggcagtag cctcctaact gatagtactc     4080

acaccagtaa ttcagggagc ttctggagtt atcctttaga aatgtaaatg aaacagtgtc     4140

accactgctt cccttcagac tcttccaagg cttctctttt tttttttatt gagacagagt     4200

ctcactctgt cgcccaagct gcagtacagt ggcaggatct cggctctctg caacctccac     4260

ctcccgggct caagtgattc tcctgcctta gcttcccgag tagctgggat tacaggcgca     4320

tgccaccagg cccagctaat ttttgtattt ttagtaggaa cagggtttca ccatgttggt     4380

caggctgatc tcgaactcct gacctcaagt gatccacccg cctgagcttc ccaaagtgct     4440

gggttataag cgtgagccac tgcacccagc cccaaggctt cttactgcac tcagaataaa     4500

atccaaatga attagtatag cctacagagt gtcaataatc tgggcctaat cacccattgc     4560

atcatccttt actgtgctcc acccatgctg gcgtcctttc tgtttattga gtgcagcaag     4620

ctttaacctg ttcgggtctt tcatttgcag tttaccctga atattccctt tctcttacct     4680

cacctttgat tggcgttttc ccccttgcag acctgcactc tggcatcctc tcctgagcaa     4740

gccttctttg attgctgcct cccaaacctg tttctcccca tttctctagc tcattggcct     4800

gtgttacttg cttcatagtg ctcactacta tctgaaatca tttcattact tgatttatgt     4860

ttgtactgtc tatttctgtc tttagaatta aaactccttg agggcaagga ctttgcttct     4920

ctggttcatg gtgggatcct catcacccag cacaagccca acacttagga gaggctcagc     4980

tagtttgaac caatggaaaa tgccattcct gaggtgcacc acatcgtttc ttttgtgttg     5040

gtgtgcatgc tgtccttcag tttgtctcct cttcccacac cctgtcatgt gctcctaaaa     5100

ctcccccttt acttggctac tttatctggc ttggcaaagc tttcccatat cccctgaccc     5160

atgtcaggga acgtttctcc tcattgctgt catggcaccc tgtgtgtggc tctgaccaga     5220

ctttgctatc cgctttgatt tctgtctttc aggggctaag tcctgcctac atcctcagtc     5280

agcatgctgc ctaacacata acagatccta agcaaatatt gggtggatga aaatcactac     5340

cattcaaggc ttcattgtat ttatcagtaa aactgaaata atatctaatg gggtcgagaa     5400

gatttactga aaatatatat ttgaaagggc tttgcagttt taagtactgt acctatgtgc     5460

attgctgtta cattcaggag atttctgagt tttagacagt cccaagcttc agcttaaaat     5520

ctgtagactg cagcccgttt ctgaaacgtt tgtactacgt gttgactagg aggaacaatg     5580

acagactctg tagtcaccgg aaatacttaa ggaatcatga ggtactatgt atttccttaa     5640

attatactgt tttttaaagc tgaagtatct aatagttaat gggttgtcca aatttgtcag     5700

aacatttgac tgtaatttaa tgtctcacca tttttcaaaa agatatatta ataccaaata     5760

ttaaaatgtg tcaagact                                                   5778


<210> 1141
<211> 5304
<212> DNA
<213> Homo sapiens

<400> 1141
cccatctcta cgaaaaatac aaaaattagc caagtatggt ggccggcgcc tgtaatccca       60

gctactcggg agactgaggc agagaactgc ttgaacctgg gaggcagagg ttgcagtgat      120

ccgagatcgc gtcactgcac tccagcgtgg gcgacagagc gagactccgt ttcagaaaag      180

aaaaaaaaaa aaaaaaaaaa gggagtcggg gtggagctct cattggctcg ttgcatgtga      240

gtgtccctac ggcctagaaa tacaagagaa gcacatcgga acgggctgga aatccaccca      300

gttaactaga gggctttgaa ccttttatta acttggaggt tgactctcct gtcaactcga      360

ttcccttttg gctgtttggc agggtcagtg agacatcccc tgggtcgctc gaccccgtag      420

gacggttcag ggagccctcc aggtcttcgt ttctcctctt ccccgcacag tgctgttatc      480

cagctggggg atccaacgca cacttaaggc tccagcaaag tggctccgct gccggatggg      540

agtgccccag tgtgctggat gaagctggcg catgcaccat gtcatcatgt gtctctagcc      600

agcccagcag caaccgggcc gccccccagg atgagctggg gggcaggggc agcagcagca      660

gcgaaagcca gaagccctgt gaggccctgc ggggcctctc atccttgagc atccacctgg      720

gcatggagtc cttcattgtg gtcaccgagt gtgagccggg ctgtgctgtg gacctcggct      780

tggcgcggga ccggcccctg gaggccgatg gccaagaggt cccccttgac acctccgggt      840

cccaggcccg gccccacctc tccggtcgca agctgtctct gcaagagcgg tcccagggtg      900

ggctggcagc cggtggcagc ctggacatga acggacgctg catctgcccg tccctgccct      960

actcacccgt cagctccccg cagtcctcgc ctcggctgcc ccggcggccg acagtggagt     1020

ctcaccacgt ctccatcacg ggtatgcagg actgtgtgca gctgaatcag tataccctga     1080

aggatgaaat tggaaagggc tcctatggtg tcgtcaagtt ggcctacaat gaaaatgaca     1140

atacctacta tgcaatgaag gtgctgtcca aaaagaagct gatccggcag gccggctttc     1200

cacgtcgccc tccaccccga ggcacccggc cagctcctgg aggctgcatc cagcccaggg     1260

gccccattga gcaggtgtac caggaaattg ccatcctcaa gaagctggac caccccaatg     1320

tggtgaagct ggtggaggtc ctggatgacc ccaatgagga ccatctgtac atggtgttcg     1380

aactggtcaa ccaagggccc gtgatggaag tgcccaccct caaaccactc tctgaagacc     1440

aggcccgttt ctacttccag gatctgatca aaggcatcga gtacttacac taccagaaga     1500

tcatccaccg tgacatcaaa ccttccaacc tcctggtcgg agaagatggg cacatcaaga     1560

tcgctgactt tggtgtgagc aatgaattca agggcagtga cgcgctcctc tccaacaccg     1620

tgggcacgcc cgccttcatg gcacccgagt cgctctctga gacccgcaag atcttctctg     1680

ggaaggcctt ggatgtttgg gccatgggtg tgacactata ctgctttgtc tttggccagt     1740

gcccattcat ggacgagcgg atcatgtgtt tacacagtaa gatcaagagt caggccctgg     1800

aatttccaga ccagcccgac atagctgagg acttgaagga cctgatcacc cgtatgctgg     1860

acaagaaccc cgagtcgagg atcgtggtgc cggaaatcaa gctgcacccc tgggtcacga     1920

ggcatggggc ggagccgttg ccgtcggagg atgagaactg cacgctggtc gaagtgactg     1980

aagaggaggt cgagaactca gtcaaacaca ttcccagctt ggcaaccgtg atcctggtga     2040

agaccatgat acgtaaacgc tcctttggga acccattcga gggcagccgg cgggaggaac     2100

gctcactgtc agcgcctgga aacttgctca cgaagcaagg cagcgaagac aacctccagg     2160

gcaccgaccc gccccccgtg ggggaggagg aagtgctctt gtgagaggca gtccctgcgt     2220

ggaaagttgc tgggcccccg cccccggctc ccccgcacgc atgcatccac tgcggccgga     2280

ggaggccatg gagcccgagt agctgcctgg atcgctcgac ctcgcatgcg cgccgcgtcg     2340

cctctggggg gctgctgcac cgcgtttcca tagcagcatg tcctacggaa acccagcacg     2400

tgtgtagagc ctcgatcgtc atctctggtt atttgttttt tcctttgttg ttttaaaggg     2460

gacaaaaaaa aaaaaaggac ttgactccat gacgtcgacc gtggccgctg gctggctgga     2520

caggcgggtg tgaggagttg cagacccaaa cccacgtgca ttttgggaca attgcttttt     2580

aaaacgtttt tatgccaaaa atccttcatt gtgattttca gaaccacgtc agatatacca     2640

agtgactgtg tgtggggttt gacaactgtg gaaaggcgag cagaaaactc cggcggtctg     2700

aggccatgga ggtggttgct gcatttgaga gggagtaggg ggctagatgt ggctcctagt     2760

gcaaaccgga aaccatggca ccttccagag ccgtggtctc aaggagtcag agcagggctg     2820

gccctcagta gctgcaggga gctttgatgc aacttatttg taagaaggat ttttaaattt     2880

tttatgggta gaattgtagt caggaaaaca gaaagggctt gaaatttaat aagtgctgct     2940

ggaaggggat tttccaagcc tggaagggta ttcagcagct gtggtgggga aacatttctc     3000

ctgaaagact gaacgtgttt cttcatgaca gctgctcaaa gcaggtttct gagatagctg     3060

accgagctct ggtaaatctc tttgtcaaat tacgaaaact tcagggtgaa atcctatgct     3120

tccatgtaca ttacatggct taagattaaa caaaaacatt tttcaagtct ctaactagag     3180

tgaactctag agcacagtag ttcagaaact atttagagct tccaggatat atttcacagc     3240

ttcaggcatg tgatcagtta gagccgatga aacctatgcc cgcctgtata tatattagca     3300

gcttagctag ttcataacct gtatattcta aagactgcta aggttttgtt ttcattttaa     3360

atcctagctg attgttgtgg tcaatgaaat acccagtttc tggagggcca ggtgggaaat     3420

gctttcactg gaccaacaca caaatgatca tcctgaggat ctgagcttcc ctagactcca     3480

cacaataacc ttggggcacc cttttagaga agactgttga aacccacagc actcgttggg     3540

gtatgaggaa accagggctt ggcacaggaa gttccccttt gtagctaaaa gtccagaaag     3600

aaagggttca tctttttgac ttccaactga tattgggaag tttggttgag gttcaagtgt     3660

gactccttcc agagccacag gtaggggagt gtgaagttga gggggaggaa agctggaagg     3720

actctgcctt gggagattcc cagctctgct ttccagcgct tggtggaatc tgggctgggg     3780

aaagacggca ccgggaaact ctgcttcccc attgtttcca tctgatcagc tgtggtgtga     3840

ggacttctca gacaaaggca aggcctcgtg cccctgccca gcccattcat ggagccctgg     3900

gccttcttgg cttccataga tcctaagctc ttgactgtag tttagccaga cttgttttgc     3960

tatcttataa gcagttcaga attagggaat gctggttttg aagagcaaag gacaggtagt     4020

ctagagaggg tcgtctggcc tgcttgctgg gtctttgtaa cccagcactt cctcttgccc     4080

tcctggcttt atgtttatgg ggagaggact caatagctcc accccttctg gcaccagatg     4140

gggcttggtt agtttgcaat aagcaccttg cagaggttaa agccagcggg tccctagtct     4200

taggcccagc ctgcttgtgt gggctctggc ctggcctggt ggctggccca gggggcagca     4260

gtgcttagag cttctgcagg gcttctcttg tttacacagc tgcatcagac aatgccattt     4320

ctccccacca cggaaccttc catctaagat ttcttccagg gaatgccagc aatcaggcag     4380

cacccagctg tgggggcagt ggggtggggg agacccacat tgatgacttt ttttttttct     4440

tttaatgaag aaacaccaaa gaaagctgtg gaaaggacct gccccacatg aaaaggataa     4500

gccaagatgg ctgtaaacac agagcatttg agctgccact cttggagcac attgattttt     4560

caaaagccag ctctgtcagg aaaggaggtg ctgttatgag cagctcttcc agtgggcaaa     4620

gaggacgccc ataatttctt ccattgctag ctcatctgtg ggaccaattt ggtgtaagca     4680

acctgtggcc tgcacttgtg gcctcgaagg aagcacaaac cctccatcca cttcccattt     4740

cctctgccct tttccacctc ccccttccat cccaccagct gccagtggct cccagaaagc     4800

cttattgagc cccttgttga cacttggggc tgcggaggcc tctccctact ggtctggcct     4860

ttcctgagag gcaggtcttc cgtcctcaga gcctttctgg aacaaggaga atgcctgtgc     4920

aggtggacac acaggcctgg cctgtcgctc tcacttgtct tccagcgggg agcttcacgt     4980

tgccgagtgg aagaaccatg acctccactt gcttccaagg tgctagggaa gtttcagggt     5040

acgctggttc ccctctccag ctggaggccg agtttctggg gactgcagat ttttctactc     5100

tgtgatcgat tcaatgcccg atgcttctgt ttcattcccg accctttcta ctatgcattt     5160

tccttttatc aggtgtataa agttaaatac tgtgtattta tcactaaaaa gtacatgaac     5220

ttaagagaca actaagcctt tcgtgttttt ccacaggtgt ttaagcttct ctgtacagtt     5280

gaaataaaca gacagcaaaa tggt                                            5304


<210> 1142
<211> 3894
<212> DNA
<213> Homo sapiens

<400> 1142
tgaggggcga accaagatgg cggcggtttt ggctgtgtga ggaagacgga agagacggcg       60

gcggagggaa accgacttcc actagtccgg gtcgcttggg cggccggggg ccctcagagt      120

ctcccgggca gtggtagcag ttgcagcagg atcaggcgcc tgtcggcttc tgacgtttaa      180

aacaggggga gcggaaggga gccactggcc gcggtggcag ggccagggcc cctttcctgg      240

gcgtctactg gcggggcccc cgccccggtt cccgggcggc acgatgaccg acacccggcg      300

gcgggtgaag gtgtacacgc tcaacgagga ccggcagtgg gacgaccggg gcaccgggca      360

tgtgtcgtct ggctacgtgg agcggctgaa gggcatgtcc ctgcttgtca gggctgagag      420

cgacggttct ctacttttag agtcgaaaat aaatcctaac actgcatacc agaaacaaca      480

ggacactctg attgtgtggt ctgaagcaga aaattatgac ttggccctta gctttcaaga      540

aaaagctgga tgtgatgaaa tttgggagaa aatatgtcag gttcaaggaa aggacccttc      600

cgtggacatc actcaggacc ttgtggatga atctgaagag gagcgttttg atgatatgtc      660

atcgccaggc ttagaattgc catcttgtga attaagtcgc cttgaagaaa ttgcagaact      720

tgtggcatca tctttacctt cacctcttcg tcgtgaaaaa cttgcactgg cactagaaaa      780

tgagggttat attaaaaagc tcctggagct ttttcatgtg tgtgaagatt tggaaaatat      840

tgaaggactg caccacttgt atgaaattat caaaggcatc tttctcttga atcgaactgc      900

tctttttgaa gttatgttct ctgaagaatg tataatggac gtcattggat gtttagaata      960

tgatcctgct ttatcacaac cacgaaaaca cagggaattt ctaacaaaaa cagccaagtt     1020

taaagaagtg attcccatat cagatcctga gctgaaacaa aaaattcatc agacatacag     1080

agttcagtat atacaagata tggttctacc aactccttcg gtctttgaag aaaacatgtt     1140

atcaacactt cactctttta tctttttcaa taaggtagag attgttggca tgttgcagga     1200

agatgaaaaa tttctgacag atttgtttgc acaactaaca gatgaagcaa cagatgagga     1260

aaaaagacag gaattggtta actttttaaa agaattttgt gcgttttccc aaacgctaca     1320

gcctcaaaac agagatgctt ttttcaagac tttgtcaaac atgggcatat taccagcttt     1380

agaagtcatc cttggcatgg atgatacaca ggtgcgaagt gctgctactg atatattctc     1440

atacttggtt gaatataatc catccatggt acgagagttt gtcatgcagg aggcacaaca     1500

gaatgatgat gatattttgc tcatcaacct cattatagaa catatgattt gtgatacaga     1560

tcctgaactt ggaggagcag tccagcttat gggcctgctt cgaactttag ttgacccaga     1620

gaacatgcta gccactgcca ataaaacaga aaagactgaa tttctgggtt tcttctacaa     1680

gcactgtatg catgttctca ctgctccttt actagcaaat acaacagaag acaaacctag     1740

taaagatgat tttcagactg cccaactatt ggcacttgta ttggaattgt taacattttg     1800

tgtggagcac catacctacc acataaagaa ctacattatt aataaggata tcctccggag     1860

agtgctagtt cttatggcct cgaagcatgc tttcttggca ttatgtgccc ttcgttttaa     1920

aagaaagatt attggattaa aagatgagtt ttacaaccgc tacataatga aaagtttttt     1980

gtttgaacca gtagtgaaag catttctcaa caatggatcc cgctacaatc tgatgaactc     2040

tgccataata gagatgtttg aatttattag agtggaagat ataaaatcat taactgctca     2100

tgtaattgaa aattactgga aagcactgga agatgtagat tatgtacaga catttaaagg     2160

attaaaactg agatttgaac aacaaagaga aaggcaagat aatcccaaac ttgacagtat     2220

gcgttccatt ttgaggaatc acagatatcg aagagatgcc agaacactag aagatgaaga     2280

agagatgtgg tttaacacag atgaagatga catggaagat ggagaagctg tagtgtctcc     2340

atctgacaaa actaaaaatg atgatgatat tatggatcca ataagtaaat tcatggaaag     2400

gaagaaatta aaagaaagtg aggaaaagga agtgcttctg aaaacaaacc tttctggacg     2460

gcagagccca agtttcaagc tttccctgtc cagtggaacg aagactaacc tcaccagcca     2520

gtcatctaca acaaatctgc ctggttctcc gggatcacct ggatccccag gatctccagg     2580

ctctcctgga tccgtaccta aaaatacatc tcagacggca gctattacta caaagggagg     2640

cctcgtgggt ctggtagatt atcctgatga tgatgaagat gatgatgagg atgaagataa     2700

ggaagatacg ttaccattgt caaagaaagc aaaatttgat tcataataat ggcaacggcc     2760

taggatcagt acctgttgaa aaaaactggt tctccacccc tcccccatac aaaatccaca     2820

acaaagcgca gtggtctctt gtgaatgact gacacagatc agcctcttac acttgacttc     2880

tgctcatcaa gtgccaattc aatggagcag gaggagggga tatcatatat ttaggggaaa     2940

gacttaagcc tttgagctct ccagcttgga ccacacattg cccttttctc agggaaggaa     3000

atggaaacaa aaagccaaca gggcaggggt tttgtaagtg gaactctgga ttgactggtc     3060

agttgctaca atcagaatat gctttcttgg accatgtttg agactcagaa gaatgggcct     3120

ttctgccata attcttcact agtcaagaat gccagcagtt tctttgtata aagagacctg     3180

cctttaaaat catacattct gaacatttta gtcaagctac aacaggtttg gaaaacctct     3240

gtgggggagg ggcgagtata aagttttcct cttttttaac tgttcccttt gcccttcaaa     3300

ctgcagatat tttttttttt aagtggggac ttctccctac ttgattaaag attgagtgga     3360

attctagatg tggtcatttg tgtcataatt tttttgtttt attttgtttt tgattttttt     3420

tttcctcccc tgagtgtatg cttagttgtt gagtatatat atttgggacc attaaaactt     3480

tttttgatgt aatataacct aacgttgtgc tggtacctgt tttaccatgt gtaatttttg     3540

ttctacatca cagttcttaa tttgtttaga gttttatgaa agatggtata gtttttattg     3600

acaaaagcaa agtaatctta caactatgtg catacaaaag caatactatt ttgtgactaa     3660

atattttata ttaaaattta catcagcaac tgtcttgaga attcagggaa atagaatgga     3720

atttaaaact tcaacagttt tgttaaatct agaaacatga aattagtatt ccaaagagat     3780

tctgaaattt cttttcttgg ggaaatgacg gtacattaaa tcaaaattga ggatggatga     3840

tttaaaaaca tttgactttt gaataataaa aagaaaagtg aagagtaaga gaaa           3894


<210> 1143
<211> 3037
<212> DNA
<213> Homo sapiens

<400> 1143
cagttcgatc aaggttgacg atgtgtcaca ctgtgtaagg gaatcgcatg gagatgggca       60

ttccgaactg ttaatgggga catgggactc cagttgtctc tgatcacttg tgtggatttt      120

cctggcgtag aacgacagaa gccgctagta agtcgccaag acctacagca ggaattctgc      180

accaaagggc ataaaatctt gttattttaa tttgcatctg ggagaatgtc tgagcaagga      240

gacctgaatc aggcaatagc agaggaagga gggactgagc aggagacggc cactccagag      300

aacggcattg ttaaatcaga aagtctggat gaagaggaga aactggaact gcagaggcgg      360

ctggaggctc agaatcaaga aagaagaaaa tccaagtcag gagcaggaaa aggtaaactg      420

actcgcagcc ttgctgtctg tgaggaatct tctgccagac caggaggtga aagtcttcag      480

gatcaggaat caattcattt acagctttcc agtttttcca gcctgcaaga ggaggataaa      540

tctaggaaag atgactctga aagagaaaaa gaaaaggata aaaacaaaga taaaacctct      600

gaaaaaccca agatcagaat gttatcaaaa gattgcagcc aagaatacac ggattctaca      660

ggcatagact tacacgagtt tctgattaac acattaaaga ataattccag ggacaggatg      720

atacttttga aaatggagca ggaaattatt gatttcattg ctgacaacaa taatcattat      780

aaaaagttcc ctcagatgtc atcgtatcag aggatgcttg tccatcgagt ggcagcttat      840

tttggattgg atcacaatgt ggatcaaaca ggaaaatctg ttatcatcaa caagaccagc      900

agcaccagaa taccagagca aaggttttgt gaacatttaa aagatgaaaa aggtgaagaa      960

tcccagaagc ggtttatctt gaagcgagat aactctagta ttgataaaga agacaatcag     1020

tcagtttgct cccaggaaag cctttttgtg gaaaacaggg gcaacagaga tggctcaggg     1080

agaacatctg ggagtcgaca gagcagctca gaaaatgaac tcaagtggtc tgaccaccaa     1140

agggcctgga gcagcacaga ctccgacagt tccaaccgca atctaaagcc cgccatgacc     1200

aagacggcga gttttggggg catcacggtg ctgaccaggg gtgacagcac ttccagtact     1260

aggagtaccg ggaagctgtc caaagcaggt tccgagtctt ccagcagtgc aggctcctca     1320

ggatcgctgt cccgcaccca tccacctctc cagagcacac ccctagtctc aggtgtggca     1380

gctggctctc caggctgtgt gccttatcca gagaatggaa tagggggcca ggttgctccc     1440

agcagcacca gctacatcct ccttccactt gaagctgcaa caggcatccc gcctggaagc     1500

atccttctta atccacacac aggccagccc tttgtgaatc ccgatggaac tcctgcaata     1560

tacaacccac ccaccagtca gcagcccctg cgaagcgcca tggtggggca gtcccaacag     1620

cagccaccac agcagcagcc ctccccgcag ccccaacagc aggtccagcc accgcagcca     1680

cagatggcag gccctctggt cactcagtct gtccaggggc tgcaggcttc ctcccagtca     1740

gtgcaatatc cagcagtctc ttttcctccc cagcacctcc tacctgtgtc tccaacgcag     1800

cactttccca tgagagatga tgtggcaaca cagtttggcc agatgaccct gagccggcag     1860

tcctcggggg agactcctga acccccatca ggtcctgtct acccatcctc ccttatgcca     1920

cagccggccc agcagcccag ctatgtaatc gcctctacag gccagcagct tcctacagga     1980

ggattctcag gctctggccc tcccatctcc cagcaggtcc tccagccccc tccctcacca     2040

cagggatttg tgcaacagcc tccgcctgca cagatgcctg tatattatta cccatctggt     2100

cagtacccta cctcaaccac gcaacagtac cggcccatgg ccccggttca gtacaacgct     2160

cagaggagtc aacagatgcc acaggcagca cagcaagcag gttaccagcc agtcttgtct     2220

ggtcaacagg gattccaagg cctaatagga gtgcagcagc cacctcagag tcagaacgtg     2280

ataaataacc aacaaggaac tccggtgcaa agcgtgatgg tttcctaccc aacaatgtct     2340

tcttatcagg tgccaatgac ccagggttct caaggactgc cccagcagtc ataccaacag     2400

ccaatcatgc tacctaacca ggcaggtcaa gggtcactcc cagccactgg aatgcctgtt     2460

tactgtaatg tcacaccgcc cacccctcag aacaacctta ggctgattgg cccacactgc     2520

ccctccagca ctgtcccagt gatgtcagct agctgcagaa caaactgtgc aagtatgagc     2580

aatgctggtt ggcaggtcaa attctgagag ctctggctgt ggtacatttc ttcagatatt     2640

tctcatggcc tttgatggaa gaggaacaag gtgggaaaac tggctgagga cttaagtatt     2700

cactcaacac tcaaatgatt gctgctggta ttctgtaaaa aataaacaaa gactaatata     2760

cacgttagct ggttaatggt gcatatttct gtcatgtctg ctaggtatgc ctttatagct     2820

tagctagtga catgaattca tcaaggtaag attttctcct accactgaat accactgtgt     2880

agattataat atccctaatt tggattagtt ttgtactttg tgttgagttt gtgatgctaa     2940

aagtatttaa aaattatata ctaaatcaca ttgtaccaaa gctgtaatgg aaaagcaaag     3000

aagaattgat gaattgaagg aataatttat atacatt                              3037


<210> 1144
<211> 1960
<212> DNA
<213> Homo sapiens

<400> 1144
gggccaagac gcccggagcg gctgctgcag ccagtagcgg ccccttcacc ggctgccccg       60

ctcagaccta gtcgggaggg gtgcgaggca tgcagctggg ggcccagctc cggtgccgca      120

ccccgtaaag ggctgatctt ccacctcgcc acctcagcca cgggacgcca agaccgcatc      180

caattcagac ttcttttggg taaagggcca agagggaagg gcgaggcggg gaggaagcag      240

ctcgggccgc cttccctccg tggcctccag gacatccgcc ggggatagat tatgcgtttc      300

cattggttac ccaccttgag cgagccgttt gatagaaacc aagagcttga aacgtgcatt      360

aggccattgt ggactcccag tgggagtgct tgtgaaactg aacacaacaa aagtatggat      420

atgggaaacc aacatccttc tattagtagg cttcaggaaa tccaaaagga agtaaaaagt      480

gtagaacagc aagttatcgg cttcagtggt ctgtcagatg acaagaatta caagaaactg      540

gagaggattc taacaaaaca gctttttgaa atagactctg tagatactga aggaaaagga      600

gatattcagc aagctaggaa gcgggcagca caggagacag aacgtcttct caaagagttg      660

gagcagaatg caaaccaccc acaccggatt gaaatacaga acatttttga ggaagcccag      720

tccctcgtga gagagaaaat tgtgccattt tataatggag gcaactgcgt aactgatgag      780

tttgaagaag gcatccaaga tatcattctg aggctgacac atgttaaaac tggaggaaaa      840

atctccttgc ggaaagcaag gtatcacact ttaaccaaaa tctgtgcggt gcaagagata      900

atcgaagact gcatgaaaaa gcagccttcc ctgccgcttt ccgaggatgc acatccttcc      960

gttgccaaaa tcaacttcgt gatgtgtgag gtgaacaagg cccgaggggt cctgattgca     1020

cttctgatgg gtgtgaacaa caatgagacc tgcaggcact tatcctgtgt gctctcgggg     1080

ctgatcgctg acctggatgc tctagatgtg tgcggccgga cagaaatcag aaattatcgg     1140

agggaggtag tagaagatat caacaaatta ttgaaatatc tggatttgga agaggaagca     1200

gacacaacta aagcatttga cctgagacag aatcattcca ttttaaaaat agaaaaggtc     1260

ctcaagagaa tgagagaaat aaaaaatgaa cttctccaag cacaaaaccc ttctgaattg     1320

tacctgagct ccaaaacaga attgcagggt ttaattggac agttggatga ggtaagtctt     1380

gaaaaaaacc cctgcatccg ggaagccagg agaagagcag tgatcgaggt gcaaactctg     1440

atcacatata ttgacttgaa ggaggccctt gagaaaagaa agctgtttgc ttgtgaggag     1500

cacccatccc ataaagccgt ctggaacgtc cttggaaact tgtctgagat ccagggagaa     1560

gttctttcat ttgatggaaa tcgaaccgat aagaactaca tccggctgga agagctgctc     1620

accaagcagc tgctagccct ggatgctgtt gatccgcagg gagaagagaa gtgtaaggct     1680

gccaggaaac aagctgtgag gcttgcgcag aatattctca gctatctcga cctgaaatct     1740

gatgaatggg agtactgaaa taccagagat ctcacttttg atactgtttt gcacttcata     1800

tgtgcttcta tgtatagaga gctttcagtt cattgattta tacgtgcata tttcagtctc     1860

agtatttatg attgaagcaa attctattca gtatctgctg cttttgatgt tgcaagacaa     1920

atatcattac agcacgttaa cttttccatt cggatcatta                           1960


<210> 1145
<211> 1363
<212> DNA
<213> Homo sapiens

<400> 1145
ccgagacctg gagcagccac cgccgcaatc atgggcttgt gctggaaaag atgaaatggg       60

gaaaatggtg tcagtaatta acactgtgga tacctcccat gaggacatga ttcacgacgc      120

ccagatggac tactatggca cccgcctggc aacctgctca tcagacaggt ccgtcaaaat      180

ctttgatgtg cgcaatggag ggcagatcct tatcgccgac ctcaggggtc atgagggtcc      240

tgtgtggcaa gtggcctggg ctcaccccat gtacggcaac atcctggcat cgtgctccta      300

tgaccggaaa gtcattatct ggagagagga aaacggcacc tgggagaaga gccacgagca      360

tgcgggacac gactcctcag tgaactcggt gtgctgggcc ccccatgact acggcctgat      420

cctggcctgt gggagctcgg atggggccat ctccctgctg acttacaccg gggaaggcca      480

atgggaagta aagaagatca acaacgctca caccattggc tgcaatgccg tcagctgggc      540

ccctgctgtt gtacctggaa gcctcataga ccacccatcg gggcagaaac ccaattacat      600

caagaggttt gcatcaggtg gctgtgacaa cctcatcaag ctgtggaagg aggaggagga      660

cggccagtgg aaggaggagc agaagctaga agcgcacagt gactgggttc gagatgtggc      720

ctgggccccc tccatcggcc tgcccaccag caccatcgcc agctgctccc aggatggtcg      780

tgtgttcatt tggacctgtg atgatgcctc aagcaatacg tggtccccta aattgttgca      840

caagttcaac gatgtggtgt ggcatgtgag ctggtccatc acagccaaca tcctggctgt      900

ctctggtgga gacaataagg tgaccctgtg gaaggagtca gttgatgggc agtgggtgtg      960

catcagtgat gtcaacaagg gccagggctc cgtatcagca tcagtgacag agggccagca     1020

gaacgagcag tgacaagaca ggtggggcct ggctccccac ccgccagctc caggactgcc     1080

ccttcctggg ccaactaacc agacaactgg gaagagcccc caactccaac aggattattt     1140

tcccaggagg agttacagat gcagccacag attgatcatc tgccttaacg tgatcggaga     1200

tgctttgtaa tctactgtcc agctgaaagc actcatgtta cgaggaagaa actacaagtg     1260

atgttcaaat ctattttggg tcatttttat gtacctttgg gttcaggcat tatttggggg     1320

gttttgtttc caaaggaact aaataaagtc atattgctta taa                       1363


<210> 1146
<211> 2746
<212> DNA
<213> Homo sapiens

<400> 1146
agcaatctcg ggaaattgga gactgacgcg gctgctcctg catgttattt atttttcctc       60

tttccctccc gtggagaccc tcctgttgga aagagagctg cagcacggga cagagacagg      120

caggaagaag cagagaggac tcggtgacgc ccccaccgag cagcccctgg cccactcctc      180

cagcaggggc catgagcacc aagcaggagg ccaggagaga tgagggagaa gccaggacga      240

gggggcagga ggcacagctt cgagaccgag cccacctgag ccagcagcgc cggctcaaac      300

aggccaccca gttcctgcac aaggactcgg ccgacctgct cccgctggac agcctcaaga      360

ggctcggcac ctccaaggac ttgcagccgc gcagtgtgat ccaaagacgc ctggtggagg      420

gaaacccgaa ttggcttcag ggggagcctc cccggatgca ggacctgatt catggccagg      480

agagcaggag gaagaccagc aggacagaga ttccagctct tctggtcaac tgcaagtgcc      540

aggaccagct gcttagagtg gccgttgaca caggcaccca atacaatcgg atctctgctg      600

gatgtctcag ccgcctgggg ttagagaaaa gggtcctaaa agcctcagct ggggacctgg      660

cccctgggcc cccaacccag gtggagcagt tggagctaca gctggggcag gagactgtgg      720

tgtgctcggc acaggtggtg gatgctgaga gtcctgaatt ctgcctgggc ctgcagactc      780

tgctttctct caagtgctgc atcgacctgg agcacggagt gctgcggctg aaagccccgt      840

tctcagagct acccttcctg cctttgtacc aagagcctgg ccagtgactg ctgtctcagt      900

cagtccccag agggaaagac cttgccttag aagaagaggc gtgtggggaa cgggggctct      960

tgaagccagg tagctgggga ctatggtgtc tgcccttcca atcacctccc tgacccctgc     1020

tgtcccattt tccccagctg gccgcattcc tctctgcttc tcagcagctg tcctactccc     1080

caggacgagt tttcactaga gggcccacga tgccaggatt ctgattcatc ttcctcccaa     1140

gaaaagcaaa gccaaatcaa gaccacagat aggaacctaa gcacaatggg gtgcctgctt     1200

gggctgggtc gaaggctctg ctgactgctg tccttgtcca tcacccaata ccaccccaaa     1260

cacaactcaa cttcccacac caccatgtct ctcaccacac cttctgggcc tcattatctc     1320

ccacaactag accgccatgc ctcaccaacc tatgtccctg gacctcctgg tgtctgcctc     1380

tcggagtctg tgcacatctg ctcacagttg agtgggggaa gaaacagcca gaattcaata     1440

caacaaagag cgggagttag tataggaatg tccatctcat aaggctgaga gctatttttt     1500

cctgtggctg caaatgtctg aagccagtta gtttgattac cctgtgcaaa accttggaca     1560

tacttctgct attaacgcta taggtattta tccgtttcca ctggcttttt gtacccaccg     1620

agcccctgag ccttgcgtgt gtgtgtgtgg aagagccttg tagagaactg ctcctgtgag     1680

gcagacagga cagtgaggtt gtcaccactc agacttcacc tattcagcat tctttctgat     1740

ttctagaact atccacctca ttaggccttc ttcctatccc catctctggc ctcttgagct     1800

taagcttgta ttgtcctgga atcagtggct ttctaacccc ctgccaggct ttgccaaagc     1860

aaaaagacag aggctttttt ttttttttta aagtttgggg tctgtcagga gacagaggct     1920

tttttgaatt cactgtgaag agaagaaccc gaaccttaag acgccagatc cctgagagtc     1980

tttctggctg gtttgagtct ctcaaatcat ggattaggag taaagaaaga ggccaggcgc     2040

aatggctcat gcctgtaatc ccagcacttt gggaggctga ggtgggtgga tcacttgagg     2100

tcaggagttt gagaccagcc tgggtaatat ggcaaaaccc catctctact aaaaaataca     2160

aaaattagcc aggtatggtg gtgaacacct gtaatcccag ctacttggaa ggctgaggca     2220

taggagttgc ttgaacctgg gagatggggg ttgtagtgag ccaagttcgt gccatcggac     2280

tccagcctgg gtgaaggagt gagaccctgt ctccaaaaac aaacaaaaaa ggagcagaga     2340

aagacagtgg tacagctaac ctgaacaagg gaactgggac cgttgggctg aaacagtctt     2400

gagcctgggg ttgactgggt tagagaagaa ccgggatgca aggagctgcc tgtgacacct     2460

ggcctgccct ttctcagctg cctcccctgc cctttctcag ctgcctcccc tgccctcaga     2520

aggaaaggag agggctcact tatcacttgt gccatagcac ctggtctcaa aatcctaaaa     2580

gctttcctcg ccctcactgc cttgctccac aaggtccact ttcctgggtc ttgtgctgtg     2640

cctttccttg tctgcctcct gctgcttctg taactgcaga ccccaggccc aatggcaagc     2700

cctcggctca gctgcttctc cattggaata aactcttgtt tctcta                    2746


<210> 1147
<211> 1709
<212> DNA
<213> Homo sapiens

<400> 1147
agacgggcgg gggagtcgcc ccggcggggc aagtccgtac cgcgacatgg gcgcgccgag       60

cacgtccgta ccgcaagatg gctgctcgga cggggacaga gctcgcctct gccgcctcga      120

caactgctcc tgggtcctct aagaggagga agcgccaccc atggcacaca gtgtcccgtc      180

ggcccggccg tacgccaaaa tggcggctcc cgcgtatttc cgctcgcgcg ccgtatcgtc      240

ttcgccgcct gcgccggcac acctattggc ccccgcggcg tcccgtcgcc gcgtcgcgtt      300

gctggcccgt cggagcgacg ccgctcgggt cagtcggcgg ccggactggg aagatggacg      360

cagctactct gacctacgac actctccggt ttgctgagtt tgaagatttt cctgagacct      420

cagagcccgt ttggatactg ggtagaaaat acagcatttt cacagaaaag gacgagatct      480

tgtctgatgt ggcatctaga ctttggttta catacaggaa aaactttcca gccattgggg      540

ggacaggccc cacctcggac acaggctggg gctgcatgct gcggtgtgga cagatgatct      600

ttgcccaagc cctggtgtgc cggcacctag gccgagattg gaggtggaca caaaggaaga      660

ggcagccaga cagctacttc agcgtcctca acgcattcat cgacaggaag gacagttact      720

actccattca ccagatagcg caaatgggag ttggcgaagg caagtccata ggccagtggt      780

acgggcccaa cactgtcgcc caggtcctga agaagcttgc tgtcttcgat acgtggagct      840

ccttggcggt ccacattgca atggacaaca ctgttgtgat ggaggaaatc agaaggttgt      900

gcaggaccag cgttccctgt gcaggcgcca ctgcgtttcc tgcagattcc gaccggcact      960

gcaacggatt ccctgccgga gctgaggtca ccaacaggcc gtcgccatgg agacccctgg     1020

tacttctcat tcccctgcgc ctggggctca cggacatcaa cgaggcctac gtggagacgc     1080

tgaagcactg cttcatgatg ccccagtccc tgggcgtcat cggagggaag cccaacagcg     1140

cccactactt catcggctac gttggtgagg agctcatcta cctggacccc cacaccacgc     1200

agccagccgt ggagcccact gatggctgct tcatcccgga cgagagcttc cactgccagc     1260

acccgccgtg ccgcatgagc atcgcggagc ttgacccgtc catcgctgtg gggtttttct     1320

gtaagactga agatgacttc aatgattggt gccagcaagt caaaaagctg tctctgcttg     1380

gaggtgccct gcccatgttt gagctggtgg agctgcagcc ttcacatctg gcctgccccg     1440

acgtcctgaa cctgtcccta gattcttctg atgtagagcg actggaaaga ttcttcgact     1500

cagaagatga agactttgaa atcctgtccc tttgaaaatc ctggggtcgg gggtggcacc     1560

tgtgagagcc tggggctcct ggtgccgctg cgtttcatcc atcccgcccg ctcgcctgcc     1620

gagggctgcg ccccgtgctg cctcccccca gagggccacc cgctgtgctc gtggactgag     1680

gctgcgctgc ccgggaggcc ttactgctt                                       1709


<210> 1148
<211> 2128
<212> DNA
<213> Homo sapiens

<400> 1148
agccttccct ttttgttttc cgtgccccaa ctcggcggat tgactcggcc ccttccggaa       60

acacccgaat caacttctag tcaaattatt gttcacgccg caatgaccca cccctggccc      120

gcgtctgtgg aactgacccc tggtgtacag gagagttcgc tgctgaaagt ggtcccaaag      180

gggtactagt ttttaagctc ccaactcccc ctcccccagc gtctggagga ttccacaccc      240

tcgcaccgca ggggcgagga agtgggcgga gtccggtttt ggcgccagcc gctgaggctg      300

ccaagcagaa aagccaccgc tgaggagact ccggtcactg tcctcgcccc gcctccccct      360

tccctcccct tggggaccac cgggcgccac gccgcgaacg taatagctct tcaagtctgc      420

aataaaaaat ggcctccaac aaaactacat tgcaaaaaat gggaaaaaaa cagaatggaa      480

agagtaaaaa agttgaagag gcagagcctg aagaatttgt cgtggaaaaa gtactagatc      540

gacgtgtagt gaatgggaaa gtggaatatt tcctgaagtg gaagggattt acagatgctg      600

acaatacttg ggaacctgaa gaaaatttag attgtccaga attgattgaa gcgtttctta      660

actctcagaa agctggcaaa gaaaaagatg gtacaaaaag aaaatcttta tctgacagtg      720

aatctgatga cagcaaatca aagaagaaaa gagatgctgc tgacaaacca agaggatttg      780

ccagaggtct tgatcctgaa agaataattg gtgccacaga cagcagtgga gaattgatgt      840

ttctcatgaa atggaaagat tcagatgagg cagacttggt gctggcgaaa gaggcaaata      900

tgaagtgtcc tcaaattgta attgcttttt atgaagagag actaacttgg cattcttgtc      960

cagaagatga agctcaataa ttgttcacat tgttctttta tatatattta tatatatata     1020

taaaaattgg gtcttagatt ttgatttact agtgtgacaa aataactaca tcctaatgaa     1080

aatcaagttt gatatgtttg ttttgaaagt agcgttggaa gagttgttgg gggttttttg     1140

catccatagc actggttact ttgaacaaat aaataaaagc tttctgtagt tgcttccttt     1200

atcagaaaag aacatttgat accatggtat atcatttcct cttcattaaa gaacagcttt     1260

tctaaatgtt gggggaaatg tccatagtca ttactcagtc aaaacttgtg ttctcatgag     1320

cctaaggacc attctagatt tattacgtgt tttttgtgtg tgtgtgtgtg tgtgtgtgtg     1380

tgtgtatcca taaaatgcat atgtaaattt ttttttgttt ttaagcattc acccaaacaa     1440

aaaaatcaca ggtaaaccca tgtttctgag atgccattat tccaagcaaa ataagagata     1500

atcccttcaa gttaaattga aaattttcct gaaaccatac atttcaagtg aaataagtaa     1560

ttctagatag gacaatttaa attggataat tttaaagtgt ctataattgc agtggtttat     1620

ttgcaaaatt cctaaaagga aaaattttat cactgccatc acagcaggtt tcctcatcca     1680

gatgaggaaa ctagacaaat gctagtgtgt tttaactagc taaacaaaac taagttaaat     1740

gaacatttaa aagtttccct agcgggccat tccttagcaa aatgttggaa tccctgttgc     1800

tacattgact aaaaggtcat gatgaatgga atatgtaaga cttggctcat agaaacctaa     1860

tcagatggtt agaggtgttg gcagtttagg acctgctgtc ataaatgtgt gaacaacctt     1920

ttgtaaccta acctattgac ctgcatgttt tttctttacc ccaattcatt acatggaggc     1980

tcaatcttga gtttgcttta ctggttcagc aaaagccagg aagaacaact ttgtagtaat     2040

caaaatgtta tccaactgta tattgtttac tttattgtaa atactggtga acagtggtta     2100

ataaatagtt ttatattcct ttatgcaa                                        2128


<210> 1149
<211> 2633
<212> DNA
<213> Homo sapiens

<400> 1149
agaaagagat aatctgtgaa agccacagag cctgatttct gctgtgataa tcttcagcag       60

accgaggctg gggcgagaat gaggcagacc tgtttacatg gtgtgtgcag tgccttgtgg      120

aattcttaac tctattttat tgtattattt ttaatcgaaa agtagatcag atgatagcat      180

gaagtgaatc ggctgctttg gactaatggg atcttctttt ctgcattaag atcaagaact      240

tttctggaat cctctgttct ccgagtagcc ttgtcttctc tgtgtgtttt atcaatttga      300

agaacactgg caaaaatcag caaacttcat ctcccaaaaa gctctcgctc ttttttgcca      360

atacttgaag atttctgctc caaaatctac tttgagctgc ttgagcatgg tggttgataa      420

ccgaagggca aaagcatcac ttatttagtg tgtgttatag aaatttttta gacaacctta      480

ctagctaacc caggtgaccc tttacggatt tctttcaaag ccaatttgaa taaacaactc      540

ttccctctca aatgggcaag agtaactctt cagcaccatg gagaggtccg ggcagcgtgt      600

tacaacgtgg gactgtgacc agggcaagca ctctgacagt gattaccgag aggatgggat      660

ggatctaggc agtgacgccg gcagcagcag cagcagcagc cgcgccagtt cacagtccaa      720

ctccaccaaa gtgacccctt gctccgagtg caaatcttca tcgtcgccgg ggggcagcct      780

ggacttggtg tctgccctgg aggactatga ggagcccttc ccggtctacc agaagaaggt      840

gattgatgag tgggcgccgg aggaggacgg ggaggaggag gaagaggagg acgagcgcga      900

ccagcgaggg taccgggatg accgctctcc ggcccgggaa ccgggggacg taagcgccag      960

gacccgcagc ggcggcggcg ggggcaggag cgccaccacc gccatgccgc ccccggtgcc     1020

caacggcaac ctccaccagc acgaccccca ggacctcagg cacaatggca acgtggtggt     1080

ggctggccgg ccgagctgtt cccggggccc ccgccgggcg atccaaaagc cccagccggc     1140

tgggggccgg cgcagtggcc gcggcccggc ggctgggggg ctctgccttc agcccccaga     1200

cggcgggacg tgcgtccccg aagagccccc ggtgccacct atggattggg aggcgctgga     1260

gaagcatctg gccgggctgc agttccggga gcaggaggta cggaaccagg gccaggcgag     1320

gaccaactcc acctccgcac agaaaaatga gagagagtct atcagacaga agttggcact     1380

tggaagcttc tttgatgatg gcccaggaat ttataccagc tgtagcaaaa gtgggaagcc     1440

aagcctttcc tcccgactgc agagtgggat gaacttgcag atatgctttg tcaacgacag     1500

tggcagtgat aaggacagtg atgctgatga cagtaagact gaaaccagct tggacacccc     1560

cttgtctccc atgagcaaac agagttcttc ctattctgat agagacacta ctgaagagga     1620

gtctgaatcc ttggatgaca tggacttcct tacaaggcaa aagaaattgc aagctgaagc     1680

caaaatggcc cttgccatgg ccaaaccaat ggccaaaatg caagtagaag tggagaaaca     1740

gaacaggaaa aagtctcccg tcgctgatct tctgccacac atgcctcata taagtgaatg     1800

cttgatgaaa agaagtttaa aacccaccga cctgagagac atgactattg ggcagctaca     1860

agtgatagtc aatgatctcc attcccagat agaaagcttg aatgaagagt tggtccagct     1920

gcttctcatc cgagatgagc tgcacacaga gcaggatgcc atgctggtgg acattgaaga     1980

cttgaccaga catgctgaaa gtcagcagaa gcacatggca gagaaaatgc ctgcaaagtg     2040

aaaagaagcc attcaaccag agaacaagct agaatttatt ttgcttctgt ggttgtaaaa     2100

atgctgttgc taaaggtggc gcagaaacaa atatcagtgt tagtcattga taatgtctga     2160

agcttaatgt ccagtgattg gcctttgctt cttaatttat tttaattttt tacttgtgcc     2220

acttaatatc aggcatttta ataaaatatt gttacaaaaa atgtacagta ctgacaccac     2280

cacaaatcat ggttaataaa agagagtagt tttaacttta tttttatttg tttagagatt     2340

ttaagttgga acagtatttt cccattgact acttttcatt cttcactgta gttttaaaga     2400

agaactgtaa atgacggtgc tatacaagtc aaaaaataca tgcctgcctc gtagtgaagt     2460

tgtagctctc cgtaatatgt atattttact cagttttcaa cattttgtga atgttgacta     2520

cctgaagttc ctttttagat gtgctattaa cattctgttg gattcagagg gttccttgaa     2580

agttttatgt ataaatatgt aaaataaaaa ttaaaacttt gtttcatatc ata            2633


<210> 1150
<211> 2296
<212> DNA
<213> Homo sapiens

<400> 1150
actcccccgc cctccccagg gccctgggaa ggggctcagc gtgggaaagg atggttgagt       60

tttaaccaga ggcaaagcgt gagcgggatc agtgtgtgcg gaacgcaagc agccgagagc      120

ggagaggcgc cgctgtagtt aactcctccc tgcccgccgc gccgaccctc cccaggaacc      180

cccagggagc cagcatgaag cgagctcacc ccgagtacag ctcctcggac agcgagctgg      240

acgagaccat cgaggtggag aaggagagtg cggacgagaa tggaaacttg agttcggctc      300

taggttccat gtccccaact acatcttccc agattttggc cagaaaaaga cggagaggaa      360

taattgagaa gcgccgacga gaccggatca ataacagttt gtctgagctg agaaggctgg      420

tacccagtgc ttttgagaag caggtaatgg agcaaggatc tgctaagcta gaaaaagccg      480

agatcctgca gatgaccgtg gatcacctga aaatgctgca tacggcagga gggaaaggtt      540

actttgacgc gcacgccctt gctatggact atcggagttt gggatttcgg gaatgcctgg      600

cagaagttgc gcgttatctg agcatcattg aaggactaga tgcctctgac ccgcttcgag      660

ttcgactggt ttcgcatctc aacaactacg cttcccagcg ggaagccgcg agcggcgccc      720

acgcgggcct cggacacatt ccctggggga ccgtcttcgg acatcacccg cacatcgcgc      780

acccgctgtt gctgccccag aacggccacg ggaacgcggg caccacggcc tcacccacgg      840

aaccgcacca ccagggcagg ctgggctcgg cacatccgga ggcgcctgct ttgcgagcgc      900

cccctagcgg cagcctcgga ccggtgctcc ctgtggtcac ctccgcctcc aaactgtcgc      960

cgcctctgct ctcctcagtg gcctccctgt cggccttccc cttctctttc ggctccttcc     1020

acttactgtc tcccaatgca ctgagccctt cagcacccac gcaggctgca aaccttggca     1080

agccctatag accttggggg acggagatcg gagcttttta aagaactgat gtagaatgag     1140

ggaggggaaa gtttaaaatc ccagctgggc tggactgttg ccaacatcac cttaaagtcg     1200

tcagtaaaag taaaaaggaa aaaggtacac tttcagataa tttttttttt aaagactaaa     1260

ggtttgttgg tttactttta tcttttttaa tgtttttttc atcatgtcat gtattagcag     1320

tttttaaaaa ctagttgtta aattttgttc aagacattaa attgaaatag tgagtataag     1380

ccaacacttt gtgataggtt tgtactgtgc ctaatttact ttgtaaacca gaatgattcc     1440

gtttttgcct caaaatttgg ggaatcttaa catttagtat ttttggtctg tttttctcct     1500

tgtatagtta tggtctgttt ttagaattaa ttttccaaac cactatgctt aatgttaaca     1560

tgattctgtt tgttaatatt ttgacagatt aaggtgttgt ataaataata ttcttttggg     1620

gggaggggaa ctatattgaa ttttatattt ctgagcaaag cgttgacaaa tcagatgatc     1680

agctttatcc aagaaagaag actagtaaat tgtctgcctc ctatagcaga aaggtgaatg     1740

tacaaactgt tggtggccct gaatccatct gaccagctgc tggtatctgc caggactggc     1800

agttctgatt tagttaggag agagccgctg ataggttagg tctcatttgg agtgttggtg     1860

gaaaggaaac tgaaggtaat tgaatagaat acgcctgcat ttaccagccc cagcaacaca     1920

aagaattttt aatcacacgg atctcaaatt cacaaatgtt aacatggata agtgatcatg     1980

gtgtgcgagt ggtcaattga gtagtacagt ggaaactgtt aaatgcataa cctaattttc     2040

ctgggactgc catattttct tttaactgga aatttttatg tgagttttcc ttttggtgca     2100

tggaactgtg gttgccaagg tatttaaaag ggctttcctg cctccttctc tttgatttat     2160

ttaatttgat ttgggctata aaatatcatt tttcaggttt attcttttag caggtgtagt     2220

taaacgacct ccactgaact gggtttgacc tctgttgtac tgatgtgttg tgactaaata     2280

aaaaagaaag aacaaa                                                     2296


<210> 1151
<211> 3126
<212> DNA
<213> Homo sapiens

<400> 1151
gcggccgcag gggtctgggc agggctgggc agtgctgccg gagcaaaagc ggtagcggga       60

gcccggccgg agctgggtct ggagacgccg tggcagcctg aacggagtgt gcgacggatt      120

gggaggtttg tctacagatt ttgagcgttc gaagttgacc cctgactaag tatactttgc      180

tgctccctca gcctttgaaa aaatgtctgt cacatatgat gattccgttg gagtagaagt      240

gtccagcgac agcttctggg aggtcgggaa ctacaagcgg actgtgaagc ggatcgacga      300

tggccaccgc ctgtgcagcg acctcatgaa ctgcctgcat gagcgggcgc gcatcgagaa      360

ggcgtatgcg cagcagctca ctgagtgggc ccggcgctgg aggcagctcg tggagaaagg      420

gccccagtac gggaccgtgg agaaggcctg gatggccttc atgtccgagg cagagagggt      480

gagcgagctg cacctcgagg tgaaggcctc actgatgaac gatgacttcg agaagatcaa      540

gaactggcag aaggaagcct ttcacaagca gatgatgggc ggcttcaagg agaccaagga      600

agctgaggac ggctttcgga aggcacagaa gccctgggcc aagaagctga aagaggtaga      660

agcagcaaag aaagcccacc atgcagcgtg caaagaggag aagctggcta tctcacgaga      720

agccaacagc aaggcagacc catccctcaa ccctgaacag ctcaagaaat tgcaagacaa      780

aatagaaaag tgcaagcaag atgttcttaa gaccaaagag aagtatgaga agtccctgaa      840

ggaactcgac cagggcacac cccagtacat ggagaacatg gagcaggtgt ttgagcagtg      900

ccagcagttc gaggagaaac gccttcgctt cttccgggag gttctgctgg aggttcagaa      960

gcacctagac ctgtccaatg tggctggcta caaagccatt taccatgacc tggagcagag     1020

catcagagca gctgatgcag tggaggacct gaggtggttc cgagccaatc acgggccggg     1080

catggccatg aactggccgc agtttgagga gtggtccgca gacctgaatc gaaccctcag     1140

ccggagagag aagaagaagg ccactgacgg cgtcaccctg acgggcatca accagacagg     1200

cgaccagtct ctgccgagta agcccagcag tgtgagcagc tacgagaaga cccagagcta     1260

tcccaccgac tggtcagacg atgagtctaa caaccccttc tcctccacgg atgccaatgg     1320

ggactcgaat ccattcgacg acgacgccac ctcggggacg gaagtgcgag tccgggccct     1380

gtatgactat gaggggcagg agcatgatga gctgagcttc aaggctgggg atgagctgac     1440

caagatggag gacgaggatg agcagggctg gtgcaaggga cgcttggaca acgggcaagt     1500

tggcctatac ccggcaaatt atgtggaggc gatccagtga tgagtcgggg acaggccagc     1560

ggggggacgg aggcggcggg cccaggagcc tcagccagcc acgtgggcat ccactccttt     1620

tcctgcaaga gatgatggtt ccattgctct tggcttcatg gtgttcctgg aaggcagatg     1680

agctggtcat ttcgcctggg actcggcacc tttccgagtg cagctggagg gatctgagcg     1740

caggaagacg cagaacaaca gaaatagccg cccctccccg cccactgtgc ctgttggcct     1800

atcatagatc tctatgttct tgactttgtc tctcctttcc gagtcaatgg tgggttacac     1860

tgatcttgtt ccactgatta ctctctctga cgagtccatc acctgcaact taaatgaaca     1920

agcttacatc ccattttgag tgaagatttt gaggttttta atttaaaggc tgtgtacagt     1980

tatacttttt tatacacctg ttcatttcta cttaaattat ggcacagatt gatgcgcacc     2040

agtcttgagg aaacgatctc cctattccct taccctgtta ctcagccacg ccgtgtgtag     2100

gcttagcctc aggtggcaga tgtttgagga aaggaattat gccaggaagg tgggaccggg     2160

ttatggtcgg gtttctattg ggaatgctct ttgtgctttt gggcatctga atggaagctt     2220

tacatagaac cttaggtaga actcccccaa atcgccatat ttaaaaatta ttttcactct     2280

attcttgctt aaaactgtac tcttttgcaa attaacaatt ttatcactga ttcagagtta     2340

aaaagaagac taacttttca agcaaatgca tctgtaaaga tgctttagat tagactgtca     2400

tgtctcagtg tctatctgta tatattattt gatattcaga gaatctaaag cactcgtcta     2460

ctgttttaat gagatttaac agcttttaac agtgagtttc gtttgtaaac tgcttgaagt     2520

ctgtggcatt caggcacacg tctggctggc cggctgggtc tcctcccggg ctcagtgggc     2580

ctggggcctc tctgacgtgg tgcctgctgg agggaggctc gtcgtcacca gctgactgct     2640

ggtccggctt ctgaccggcc tttgtcctgg ctccgtagca gaacactgta aaagtgcccg     2700

cgtctttgca gtagttgcag atttcagtcg tcgtgttact tgtgcacaaa cagaagctgg     2760

gtcttacccg cagcacgagt gtctcgggct gcccggagtc gcccgggagc aggtgctgca     2820

gccagagtta cgcgggggcc acgcgggccg gcgggggtgg ggggaacgtg ggggaacctg     2880

tgtttcacgt gactcagcag tgcccgccgc cgtcaccagc tatgcattca ctccgtttcc     2940

agtgagcaga tgtcttgctt ggaaagtgga cctgtgtctg tgtctgtcct gagaacttac     3000

cagcagaaat cctcatttct gtgctacgga tttaccaaaa attgtcaagt ctttttcagt     3060

ttaacagttc ctttacatgt gtagtatttg aggaaaaaaa tcaataaaca gttgatctcg     3120

tgcata                                                                3126


<210> 1152
<211> 2186
<212> DNA
<213> Homo sapiens

<400> 1152
gtcgtggaag caggactgcg ccgcgtcttc ctcaaggtgg ggttcggggg gccaccgaat       60

cgctgtcacg ccggcaggtt gagaacaaaa acatgcacct ggagtttccc cggagccctc      120

tgcgtggttg agcttcggtg gaatttcggg gctcttggct gccagccgcg cttgcctggt      180

agcaacagaa accagtcctg ctcgcctccg tggacatttc attaccatcc agaagtgtct      240

cccactgaag gcatccgtgg ttgtttttaa gccacaaaaa agccacaccc aagatcacct      300

gacacccacc ctgacaagtg tccatgatgc tgggccctga gggaggtgaa ggctttgtgg      360

tcaagctccg tggcctgccc tggtcctgct ctgttgagga cgtgcagaac ttcctctctg      420

actgcacgat tcatgatggg gccgcaggtg tccatttcat ctacactaga gagggcaggc      480

agagtggtga ggcttttgtt gaacttggat cagaagatga tgtaaaaatg gccctgaaaa      540

aagacaggga aagcatggga caccggtaca ttgaggtgtt caagtcccac agaaccgaga      600

tggattgggt gttgaagcac agtggtccca acagtgccga cagcgccaac gatggcttcg      660

tgcggcttcg aggactccca tttggatgca caaaggaaga aattgttcag ttcttctcag      720

ggttggaaat tgtgccaaac gggatcacat tgcctgtgga ccccgaaggc aagattacag      780

gggaagcgtt cgtgcagttt gcctcgcagg agttagctga gaaggctcta gggaaacaca      840

aggagaggat agggcacagg tacattgagg tgtttaagag cagccaggag gaagttaggt      900

catactcaga tccccctctg aagttcatgt ccgtgcagcg gccagggccc tatgaccggc      960

ccgggactgc caggaggtac attggcatcg tgaagcaggc aggcctggaa aggatgaggc     1020

ctggtgccta cagcacaggc tacgggggct acgaggagta cagtggcctc agtgatggct     1080

acggcttcac caccgacctg ttcgggagag acctcagcta ctgtctctcc ggaatgtatg     1140

accacagata cggcgacagt gagttcacag tgcagagcac cacaggccac tgtgtccaca     1200

tgaggggcct gccgtacaaa gcgaccgaga acgacattta caacttcttc tctcctctca     1260

accctgtgag agtccatatt gagattggcc cagatggaag agtgacgggt gaagcagatg     1320

ttgagtttgc tactcatgaa gaagctgtgg cagctatgtc caaagacagg gccaatatgc     1380

agcacagata tatagaactc ttcttgaatt caacaacagg ggccagcaat ggggcgtata     1440

gcagccaggt gatgcaaggc atgggggtgt ctgctgccca ggccacttac agtggcctgg     1500

agagccagtc agtgagtggc tgttacgggg ccggctacag tgggcagaac agcatgggtg     1560

gctatgacta gttttgttag gaacatttga gttacttcaa tcattttcac aggcagccaa     1620

caagcaatta agagcagtta taatagagga agctggggga cccattttgc accatgagtt     1680

tgtgaaaaat ctggattaaa aaattacctc ttcagtgttt tctcatgcaa aattttcttc     1740

tagcatgtga taatgagtaa actaaaacta ttttcagctt ttctcaatta acattttggt     1800

agtatacttc agagtgatgt tatctaagtt taagtagttt aagtatgtta aatgtggatc     1860

ttttacacca catcacagtg aacacactgg ggagacgtgc ttttttggaa aactcaaagg     1920

tgctagctcc ctgattcaaa gaaatatttc tcatgtttgt tcattctagt ttatattttc     1980

atttaaaatc ctttaggtta agtttaagct ttttaaaagt tagttttgag aattgagaca     2040

caatactaat actgtaggaa ttggtgaggc cttgacttaa aactttcttt gtactgtgat     2100

ttccttttgg gtgtattttg ctaagtgaaa cttgttaaat tttttgttaa ctaaattttt     2160

ttcttaaaat aaagactttt tcacaa                                          2186


<210> 1153
<211> 3758
<212> DNA
<213> Homo sapiens

<400> 1153
cttttctgcg gctgcactga agggttcggc tgcccatccg tcacagaggc gatgcctctg       60

attggctgct gctcttcggg ccgggaggcg gggcgggaag gccggagaaa ctagtttgtt      120

ggcggcgcct aggctgtatc gcagcgagag cgtttttgcc tgtggagagc cggccgacgg      180

gagccgcggc ggagcctgtt gagctcgcgc gggctgccgg gagtggtctc tgaggcggcg      240

gcggcggcgg ggatcgtctc cggcactgac gcaccatgtc ggtcagtgtc catgagaccc      300

gcaagtcgcg gagcagcacg gggtccatga acgtcaccct cttccacaag gcctcccacc      360

cggactgtgt gctggcccac ctcaacacgc ttcgcaagca ctgcatgttc accgacgtca      420

cactctgggc gggcgaccgt gccttcccct gtcaccgtgc cgtgctggcc gcctctagcc      480

gctattttga ggccatgttc agccatggcc ttcgggagag ccgggatgac actgtcaact      540

tccaggacaa cctgcacccg gaggtgctgg agctgctgct ggactttgcc tactcctcac      600

gcatcgccat caacgaggag aacgctgagt cactgctgga ggcaggcgac atgctgcagt      660

tccacgatgt gcgggatgct gccgccgagt tcctggagaa gaaccttttc ccctccaact      720

gcctgggcat gatgctgctc tcggacgccc accagtgccg ccggctgtat gagttctcct      780

ggcgcatgtg cctggtgcac tttgagacgg tgaggcagag cgaggacttc aacagcctgt      840

ccaaggacac actgctggac ctcatctcga gtgatgagct ggagaccgag gacgagcggg      900

tggtcttcga ggccatcctc cagtgggtga agcacgacct ggagccacgg aaggtccact      960

tgcccgagct cctccgcagc gtgcgtctgg ccttgctgcc gtccgactgc ctgcaggagg     1020

ccgtctccag cgaggccctc ctcatggcag acgagcgcac caagcttatc atggatgagg     1080

ccctgcgctg caagaccagg atcctgcaga atgatggcgt ggtcaccagc ccctgtgccc     1140

ggccacgcaa ggcgggccac acgctactca tcctgggggg ccagaccttc atgtgtgaca     1200

agatctacca ggtggaccac aaggccaagg agatcatccc caaggccgac ctgcccagcc     1260

cccggaagga gttcagcgcc tcagcgatcg gctgcaaggt ctatgtgacg gggggcaggg     1320

gctccgagaa cggggtctcc aaggatgtct gggtgtacga caccgtacat gaggaatggt     1380

ccaaggcggc gcccatgctg attgcccgct ttggccatgg ctcagctgag ctggagaact     1440

gcctctatgt ggtgggggga cacacatccc tggcaggggt cttcccggcc tcgccttctg     1500

tctccctgaa acaagtggag aaatacgacc ctggggccaa caagtggatg atggtggccc     1560

ccttgcggga tggcgtcagc aatgccgcag tggtgagtgc caagctgaag ctctttgttt     1620

tcggaggaac cagcatccac cgggacatgg tgtccaaggt ccagtgctat gacccctcgg     1680

agaacaggtg gacgatcaag gccgagtgcc cccagccttg gcggtacaca gccgctgccg     1740

tcctgggcag ccagatcttc atcatgggag gtgacacgga attcacagcc gcctcggcct     1800

accgctttga ctgtgagacc aaccagtgga cgcggattgg ggacatgact gccaagcgca     1860

tgtcctgcca tgccctggct tccggcaaca agctctatgt ggtcgggggc tactttggga     1920

cccagaggtg taagactctg gactgctatg accccacttc agatacatgg aactgcatca     1980

ccacagtgcc ctactcactt atccccacgg cctttgtcag cacctggaag cacctgcccg     2040

cgtgaggagc acctgctgag cccagccaga ccgcggcctt cagtgtcaca gcgtggcctt     2100

gcttgtctgc cacagcggga gctaagccgg ccctgggcca gcactccgag aggtggaagg     2160

ggccctgcca gctctgggga gcagcagcct tgggctgttc tgagctttag gcaagagaag     2220

agaagcatct cttgcatccg tgcccctggg ggcctcttca gctttgcagt ggtttgtggg     2280

aagacatacc tcccagaggg gcatggactg ccaccaggac tgaccctggc gtcggggaga     2340

aggacacttg cagagccttg agatcacctg tttggcaggt cctggactgg ggccgggcag     2400

gcaggggcag ggaggcgccc cgggtgggct ttggggctgc ggcactgcca cacatccttt     2460

ccctcctggc ctgccctgct ggggctctac tgccatctat agatggtgtc ctgggcctgg     2520

gaaactaggt tcccaggggt tgagaccaga aaggtgacca agacagattt tttaaggtgc     2580

agaaactgca ggggggcctc agtgacatcc atgaggcctt attagcaaag gacacccaga     2640

cctccaaggt ttgtgggccc cttccacaaa gctgtaagtc ccagcccacc tactcagggc     2700

cttgctcagt gctgtggccc ggtggggaca cagttgctcg tggccactca gtggagctgg     2760

gcctgcagca gactcaaggc tccgagtgcc ctgggggtca cccctcccct cccctcctca     2820

gagcccaccc tgagaggcag cagtgacccc catggcacac acctgccaac agcactgggg     2880

gcttctcccc aggagaccac gctgccctcc aagaccagga gcagctgtga gctggagaca     2940

gcagagggac cccagggtgt cccctgcaga tcccaccagg gccgcatcca tctcagtgtg     3000

gaggacagtg acgggaccct caccatcctc ttgcgttttg gcccccattt gctccctgag     3060

ctccaagata agaatggccc cgagagaact gctgaacatt tgttcattgc tgtcacctcc     3120

tgagtcactg gggtccctca ccagcacctc cctgacacct gggctatgga gaggttggcg     3180

cctgtcagtg accatcctaa tgcctctcgc tcactcccaa gccaccattt gagagggagg     3240

ggtgttggtg ccctgacagg gactgggcag ggtgtccaaa cttggggctt cccaggcacc     3300

tgcagtgtga acactgcttg gctggctcaa gattagggcc gcggaggggg ctgtgcacat     3360

accagttact taagcagcca cgagtgtccc ccatgccttg gtgcgggtcc tggaggcctc     3420

ttgggggtgg gacctttggg cagggtttgc ccactgacac gcccgccatg gggcactggc     3480

tgcatggggc tccttggacc ctgtagaccc agcagacccc gcctgtgtca ggccagctgc     3540

ccgaaggcac ttggctgtgg tcccagggga cggctctgct ggcacactca ggagcctggc     3600

cgcggggact gcagggaggg tgcctggacc cgtggggttg cttcattgag ataaagcaca     3660

cttatcacat agcacaaagg acgtgccatg gtgctttccc caaaagttgt gttgctttta     3720

tcagttttct aacttaataa aaagagttga gaaaattc                             3758


<210> 1154
<211> 1688
<212> DNA
<213> Homo sapiens

<400> 1154
cgcgcaacgg ccgggcaccc ggcggttcag gtcgcttaga gagtcgtagg ttgggtagtg       60

cgggttgggg cgggggctgc ggagagggtg cttaactgag gggcatgatg ggggaggcgg      120

ccgtggccgc ggggccttgt ccgttgcgcg aggacagctt cacgcgcttc tcgtcgcaga      180

gcaatgtgta cgggctggca ggcggcgccg gcgggcgcgg ggagctgctg gccgccaccc      240

ttaaaggcaa ggtgctcggc ttccgctacc aagacctccg acagaaaatc cggccagtgg      300

ccaaggagct gcagttcaac tacattcccg tggatgcgga gattgtctcc atcgacactt      360

tcaacaagtc accccccaag cggggtctgg ttgtggggat cacgttcatc aaggattcag      420

gggacaaggg cagccccttc ctgaacattt actgcgacta cgagcccggc tctgagtaca      480

accttgactc tattgcccag agctgcctga acctggagct ccagttcact ccgttccagc      540

tgtgccatgc ggaggtccag gtcggggatc aacttgagac tgtgtttctc ttgagtggga      600

acgacccggc cattcatctc tacaaggaga acgaggggct gcatcagttt gaggaacagc      660

ccgtggaaaa cctcttccca gagctgacga acctgaccag tagcgtcctc tggctggacg      720

tccacaactt ccccggcacg tcccggcgcc tctcagctct gggctgtcag agtggttatg      780

tccgtgtcgc ccacgtggac cagcggagtc gagaggttct gcagatgtgg tcggtcctgc      840

aggacggtcc catctcccga gtgattgtgt tcagcctctc ggccgccaag gagaccaagg      900

acaggccact acaagatgag tacagcgtgc tcgtggccag catgttggag ccagcagtgg      960

tgtatcggga cctgctgaac cggggtcttg aagaccagct tctcctgccc ggcagtgacc     1020

agtttgacag cgtcctctgc agcctggtca ccgatgtgga tttggatggg cggccagaag     1080

tcctggtggc cacctatgga caggaactgc tgtgttataa gtaccggggc ccagagtcgg     1140

ggcttcctga ggcccagcac gggttccatc tgctgtggca gcggagcttc tccagtcccc     1200

tgctggccat ggctcacgtg gacctgaccg gggatgggct gcaggagctt gccgtggtct     1260

ccctgaaggg cgtgcacatc ctgcagcaca gcctgattca ggcctcagag ctggtcttga     1320

cccggcttcg acatcaagtg gagcagagga gacgtcggct acaggggttg gaggacgggg     1380

caggtgcagg gcctgctgag aatgcagcct cttaagcacc catgcaccca ctcttcccag     1440

acctggggcg actcatggcg tgctcacctc cagccgctgg tggggggtgt cctgaaggac     1500

aggatgctct ccccagacct ccccagggtg gtgaagctgt gccctggggc cccagctaac     1560

ccactcctct ctctgtacgt caatgtccct atttgaaagc agggatgatc ccattccacc     1620

ctgtccactc tggatgagaa ttggccacct gatggttatt tatacgtcca gaagaacatc     1680

atttccca                                                              1688


<210> 1155
<211> 1622
<212> DNA
<213> Homo sapiens

<400> 1155
gcactgcggg acatggtgat gtcctgggtt ggggctgagg aaggcctatg cgcggagggt       60

gcggccttcg gctaaggcag aggaccaggg ttgggtccgt ggcggcggga ggggtggcct      120

cctgcgctgg tcgccccagg ggacctgaga ggcgcgacaa acagtcggcg cgtttggtac      180

tcgcgcctgc agagctttca acctccgcgc cggctgcgcc tgtttctcgg ccaggggagc      240

aaggccacgc ggcctacgca gccgagtcgg aaccaaccgg ttgtttggtg aaacctaccc      300

cagagcctcc cgcggcccac agagcacaga cagaatctcc ctctgtcacc caggctggag      360

tgcagtggca tgatctcggc tcactgcaac ctccacctcc cgggttcaag cgattcttgt      420

gcctcagcct ccggagtagc tgggatttac agacgtgcgc taccatgccc ggcaaatttt      480

tctatttttg caaagacagg atttcaccgt tttgtccagg ctggtcttga actattgacc      540

tcaagtgatc cgaccgcctt gacctcccaa agtgctggga ttacggggtg tgagccatcg      600

cgcctggcca ctttctccaa agttttaaac caaagccttc ttcggcagag ctacgaccct      660

tcctctatgg cccattctat cctatgctgc ttccctttat aaggacactc ccactgttgt      720

gctataatca tctcttggta tctccggact ctgccactct gagccctcct tacagcctag      780

aaaaaatgac agatctcgta gctgtttggg atgttgcttt aagtgacgga gtccacaaga      840

tcgaatttga acatgggact acatcaggca aacgagtagt atatgtagat ggaaaggaag      900

agataagaaa agagtggatg ttcaaattag tgggcaaaga aacattctat gttggagctg      960

caaagacaaa agcgaccata aatatagacg ctatcagtgg ttttgcttat gaatatactc     1020

tggaaattaa tgggaaaagt ctcaagaagt atatggagga cagatcaaaa accaccaata     1080

cttgggtatt acacatggat ggtgagaact ttagaattgt tttggaaaaa gatgctatgg     1140

acgtatggtg caatggtaaa aaattggaga cagcgggtga gtttgtagat gatgggactg     1200

aaactcactt cagtatcggg aaccatgact gttacataaa ggctgtcagt agtgggaagc     1260

ggaaagaagg gattattcat actctcattg tggataatag agaaatccca gagattgcaa     1320

gttaatgaat tttcatctta agaagtaaag atcaggactt tttaattact gtggtaatta     1380

aatgtgttca gtatgtactt atcagtacat ttagtctgca atgttttaat tttttaaaaa     1440

gttacatgaa actaacattc caagggtcag gaaaaaaacc aattatgtat agtcataaaa     1500

attacaattt atgatgcaaa taatgtaaaa tgttttaaag acaaatggca aataagatat     1560

ggaccaaagt cactaatgtt ttacaacagt aacctttact ataataaata cttttaaaaa     1620

aa                                                                    1622


<210> 1156
<211> 663
<212> DNA
<213> Homo sapiens

<400> 1156
atgacatctg gagaagtgaa gacaagcctc aagaatgcct actcatctgc caagaggctg       60

tcgccgaaga tggaggagga aggggaggag gaggactact gcacccctgg agcctttgag      120

ctggagcggc tcttctggaa gggcagtccc cagtacaccc acgtcaacga ggtctggccc      180

aagctctaca ttggcgatga ggcgacggcg ctggaccgct ataggctgca gaaggcgggg      240

ttcacgcacg tgctgaacgc ggcccacggc cgctggaacg tggacactgg gcccgactac      300

taccgcgaca tggacatcca gtaccacggc gtggaggccg acgacctgcc caccttcgac      360

ctcagtgtct tcttctaccc ggcggcagcc ttcatcgaca gagcgctaag cgacgaccac      420

agtaagatcc tggttcactg cgtcatgggc cgcagccggt cagccaccct ggtcctggcc      480

tacctgatga tccacaagga catgaccctg gtggacgcca tccagcaagt ggccaagaac      540

cgctgcgtcc tcccgaaccg gggctttttg aagcagctcc gggagctgga caagcagctg      600

gtgcagcaga ggcgacggtc ccagcgccag gacggtgagg aggaggatgg cagggagctg      660

tag                                                                    663


<210> 1157
<211> 2445
<212> DNA
<213> Homo sapiens

<400> 1157
ggcaagatgg ctcccctgca tgtctccggc tgatcgctgc cgctccgcca atacaataga       60

gccagccact accagcagcc tggccctctt cctccttctc cagagagacc aatccagccg      120

aactcggggt ttgcctgagg agaaggagga agtgaccatg gacacaagtg aaaacagacc      180

tgaaaatgat gttccagaac ctcccatgcc tattgcagac caagtcagca atgatgaccg      240

cccggagggc agtgttgaag atgaggagaa gaaagagagc tcgctgccca aatcattcaa      300

gaggaagatc tccgttgtct cagctaccaa gggggtgcca gctggaaaca gtgacacaga      360

ggggggccag cctggtcgga aacgacgctg gggagccagc acagccacca cacagaagaa      420

accttccatc agtatcacca ctgaatcact aaagagcctc atccccgaca tcaaacccct      480

ggcggggcag gaggctgttg tggatcttca tgctgatgac tctcgcatct ctgaggatga      540

gacagagcgt aatggcgatg atgggaccca tgacaagggg ctgaaaatat gccggacagt      600

cactcaggta gtacctgcag agggccagga gaatgggcag agggaagaag aggaagaaga      660

gaaggaacct gaagcagaac ctcctgtacc tccccaggtg tcagtagagg tggccttgcc      720

cccacctgca gagcatgaag taaagaaagt gactttagga gataccttaa ctcgacgttc      780

cattagccag cagaagtccg gagtttccat taccattgat gacccagtcc gaactgccca      840

ggtgccctcc ccaccccggg gcaagattag caacattgtc catatctcca atttggtccg      900

tcctttcact ttaggccagc taaaggagtt gttggggcgc acaggaacct tggtggaaga      960

ggccttctgg attgacaaga tcaaatctca ttgctttgta acgtactcaa cagtagagga     1020

agctgttgcc acccgcacag ctctgcacgg ggtcaaatgg ccccagtcca atcccaaatt     1080

cctttgtgct gactatgccg agcaagatga gctggattat caccgaggcc tcttggtgga     1140

ccgtccctct gaaactaaga cagaggagca gggaatacca cggcccctgc accccccacc     1200

cccacccccg gtccagccac cacagcaccc ccgggcagag cagcgggagc aggaacgggc     1260

agtgcgggaa cagtgggcag aacgggaacg ggaaatggag cggcgggagc ggactcgatc     1320

agagcgtgaa tgggatcggg acaaagttcg agaagggccc cgttcccgat caaggtcccg     1380

tgaccgccgc cgcaaggaac gtgcgaagtc taaagaaaag aagagtgaga agaaagagaa     1440

agcccaggag gaaccacctg ccaagctgct ggatgacctt ttccgaaaga ccaaggcagc     1500

tccctgcatc tattggctcc cactgactga cagccagatc gttcagaaag aggcagagcg     1560

ggccgaacgg gccaaggagc gggagaagcg gcgaaaggag caagaagaag aagagcaaaa     1620

ggagcgggag aaggaagccg agcgggaacg gaaccgacag ctggagcgag agaaacgtcg     1680

ggagcacagt cgggagaggg acagggagag agagagagaa agggagcggg acagggggga     1740

ccgagatcgg gatagggaaa gggaccgaga acgaggcagg gaaagggatc gcagggacac     1800

caagcgccac agcagaagcc ggagtcggag cacacctgtg cgggaccggg gtgggcgccg     1860

ctagctggga aaacactaga gctgcaggta ccagccactc ggccccaggg ggttatggcc     1920

acagagggat aggcacagtc tccaccaccc tggagccaag ggtctttcac atcacctatc     1980

cctacataca taccaaatgg aaaagtggcc atccttttcc ccccaaacac acccccttaa     2040

cctatctctt gggacttagc ccgaccctcc ctctcatttc ccattaagtc tgagaggcaa     2100

gagctaggtt aggcaaggag gtggttggcc agagatgggg aacagccagg tgccccagtc     2160

ctctgatttt tcctccatcc tgcttaccac ctccctgggt acttacagcc ttctcttggg     2220

aacagccggg gccaggactg ggtcacctat gagctgaatc agcatctcct cctgagtccc     2280

agggcccctg cagttcccag tctcttctgt cctgcagccc ttgcctcttt cccacaggtt     2340

ccactttata tccacctttt ccttttgttc aatttttatt tttatttttt ttattattaa     2400

atgatgtggt ctatggaaaa aaaaataaaa atctgactta gtttt                     2445


<210> 1158
<211> 6661
<212> DNA
<213> Homo sapiens

<400> 1158
atgaagaacg agcctctgac tccaggttat catggattcc cagcgcggga cagccagggt       60

aaccaggagc cgacaacaac tcctgacgca atggttcagc cttttactac catcccattt      120

ccaccacctc cgcagaatgg aattcccaca gagtatgggg tgccacacac tcaagactat      180

gccggccaga ccggtgagca taacctgaca ctctacggaa gtacgcaagc ccacggggag      240

cagagcagca actcacccag cacacaaaat ggatctctta cgacagaagg tggagcacag      300

acagacggcc agcagtcaca gacacaaagt agtgaaaatt cagagagtaa atctaccccg      360

aaacggctgc atgtctctaa tattcctttc cgcttccggg accctgacct ccggcagatg      420

tttgggcagt ttggcaaaat cctagatgta gaaataatct ttaatgaacg tggctctaag      480

ggattcgggt tcgtaacttt cgagaatagt gctgatgcag acagggccag ggagaaatta      540

cacggcaccg tggtagaggg ccgtaaaatc gaggtgaata atgctacagc acgtgtaatg      600

accaataaga agatggtcac accatatgca aatggttgga aattaagccc agtagttgga      660

gctgtatatg gtccggagtt atatgcagca tccagctttc aagcagatgt gtccctaggc      720

aatgatgcag cagtgcccct atcaggaaga gggggtatca acacttacat tcctttaatc      780

attcctggct tcccttaccc tactgcagcc accacggcag ccgctttcag aggagcccat      840

ttgaggggca gagggcggac agtatatggt gcagtccgag cggtacctcc aacagccatc      900

cccgcctatc caggtgtggt ttaccaggac ggattttacg gtgctgacct ctatatagaa      960

tctgcaaact gcttcagatc aaacagggtg gatatgcagc ctacagatat gcacagcctg     1020

ctactgcaac cgcagccacc gctgctgcag ccgctgcagc cgcttacagt gacggttatg     1080

gcagggtgta cacagccgac ccctaccatg cccttgcccc tgccgctagc tatggagttg     1140

gcgctgtggc gagtttatac cgaggtggct acagccgatt tgccccctac tgaagtgacg     1200

tgagacccct gcaaatggga cagcccccca gttcatgagg cctggctatt gcaatattta     1260

ctagtagagg aactctatag caagatgaag aggaaaaaca aacaaacaaa caaaaaaaaa     1320

cacaaaaaaa gaaagaatac ttttttatac ctcactatgt tctttgaata tgtatttttc     1380

ctttaaattt ctgcctttaa ttcttttgtt ccaaagattg tgcatttttt tctttttttt     1440

tttaaactgt ggtaaaaaaa aaaaaaataa tgcatttcca tgtctgtatg tccgtgctta     1500

gcttattcta tcaatcacgg aagaggcagt caaggaggaa ggagagacat taggagccga     1560

taaatgcatc tgatcagaaa tcagcagaca gaattaccaa agtgtatctg gtgctgaatg     1620

actgggggac aagcagaagt ggaagagatc tttctgcaac aggatattct tctagtcttc     1680

tgagtttctg gtctttgaca ggcaattctg gttggctgtg gctggaatcc acatgctgat     1740

agataggaat ttgtgcttac aaagcaggag aattaaaaag acgctttcct ctcctcttcc     1800

ctcctgtctt ctccgttctt tttacaatca tcttacacgc acagcctgag acagctggca     1860

tagtttttgg aattatagta ttgatatttc caaacgtgct ctcagacagt ggataataaa     1920

cacctcatta ggaaaccgat ctcagaatga actctggagt atgaaaaaga tcatttcttt     1980

ttgttcctgt aacctagcat tccttctagg cttcttctcc tttaattgaa ccacagctta     2040

gctcatgtat tcttttatta acaccctgct ctcatgtcca taagattcag gaatttagga     2100

cccagggaca gaaaagtgaa taagccagtg accagatttc ccccagatgt cttgaggatt     2160

agaagtacaa attgttgaca gccattaaag agggtgagga agggaaaagg aatattagaa     2220

gatctggtat ttcttacttt tttcttgcct cagaaagtac aaagtttaaa aaatagaata     2280

aagaatctgc tggggaaaga tagagtacca ggtcctaggt cagtagtccc tggaagtttt     2340

ggtgatgagg acatggaagg gcaggcagag gcactttgta cttgctccaa agccatagga     2400

attttcatct tccagagcct ttatgagtca cttctctatc cacagtcttg agcctgtggc     2460

tatcccgctg agcttctcac tgtcctccaa aaacaccccg ctgagcaccc ggaccacttt     2520

gtacacatta acactacagg acataaaatg cagaggccct gagattgctg ccctcccata     2580

ttggaaggag ggtctgcgat ggcaagggtc ttctatatca ccagaaagag tcgcgcagtg     2640

agtcactgcc gttgccatct ggctgtaatt ttctatgtta tcaaggtagg agggagtgtt     2700

tctcttctag ctgttagata gaactgataa aagcaagtgt cctacagcat ttcccaaatg     2760

aaggcattag gaaatagaaa agcacggtct ttttggctcc ctggtctagt cacattggta     2820

ctagggtgac ctttcaccca agggacagct gctaaaggga gtaattcaga gacatggagc     2880

ttctggttat gggtttgttt tgggtttgtt tttaactcct gcctccacac atgttcttga     2940

ctgataactg actcatgtcc ctgaattaaa atgactgacc tatgacagca tcaagcattc     3000

tttgtaagca gagtgatata tctgagaggg cgttgacctg ttgtgtagaa tacatatcct     3060

ttcccccttc agaatcctgt ctcgcctcgt aactgggaga gaggctgtgc ctgaaactag     3120

gggcgatgtc aaggaagcta gaggcctcga tgcaattatt actgactctg gggaggaaga     3180

cagagaataa ggggacacca actgcccagt ccactggcca tttttaaggg tccccccacc     3240

ccaagccaaa gtttggtttg ttgctgttaa gacaattttt gttgtatgta tataaatatt     3300

ttagttagag gagcggggaa tgggatgcgg gctttcacag ttctagggaa tgggggcagg     3360

gaggattttg cttttgcttt tgctttgagg gagaacttta gctgactaaa aaaacagaag     3420

tttggggtca tgatcacaaa ggggccattc ccaaaagatg gcaagccacg tattcagtgg     3480

agactaggcc aaattctaaa tggttttatc catagcaggg gagaatagga gaatgagttt     3540

aagagttttt ctcttctttt ttcctagaaa gaggtaagga taatgggaaa ggtagagaag     3600

gcggctccca cagacctttt aagagaggca gaatcttgag cttgaggcac cttgagtgca     3660

tctcagttca gctggttctg gctgaggcct ccaaaggcaa gctctgtgct ttccagtggt     3720

ttctgctgca tttccaggga tggtgtttaa caccgcttcc tccagctccc ttttctaaga     3780

aagaataaat ggagttctgc tttttatgaa agggtctttg gttttcagtg tcaacactga     3840

gaattggggc tcttgcaagc atctggattt cacagtatca acctccccgt caccttttga     3900

actttgagac tccgtacggt caacttcacc agaggcaggt tgctcgaagc agcactgctt     3960

gtctgttcct gactctggtt ctcactgtat taaaaaagag agtcagagga gtctggcatt     4020

tcgtgagttt gttagaggat gctggctgat aattccagaa aacttactga tgctaaatca     4080

cagtacatgc atgattcttt ttcagcttta ctatagttca tgacctggac tttctgtact     4140

cttggaagct gggctcctta aaggaggcct ctagtgaaca cctttatctc catgtccctc     4200

ttagagccca gagagctgcc cataggcatt ttccagaatt cctcatgtca cctagttcaa     4260

tttccattaa ctcagatcag ccattgtgat tcaccatttg tcaggctctc aggtttaaca     4320

aaacctacta tcaccatcat ccttcaacag ccacagtctg aattgagcca acattttttt     4380

ttctttgaga aagaagtgga ctggggcaca acttttagtc tgaggggagc tagtggaaat     4440

ctagacaata gaagtcatcg atagcagctt ttcctcaaat gtgtgactcc tcaggggcta     4500

aactgctctt agcttagaat tatgctttac tagagatcta gcagataagt gggttaatca     4560

ctaccatcct gtaactagtt atatagcttc cagacatgag ggagacatca aacagggatg     4620

gaagcaaccc caaggatatg caagaagggc atgatgaacc cccttccctc tggcaggaga     4680

acaaggccaa ccaagggaca gactggaaag cacttagatg tttaaggagg agaaagggga     4740

agctttgacc agtccttgcc ttttgccaag ttcagccagt tctccgctgc ttgcaacctc     4800

tagcgcagta acatttgcag aattgcagat tttcccccag atactaggag gaaagggact     4860

ttggggggtg gggaaggggt cgtggtgttt taaaagcata agttacctgt ttgcactgtt     4920

ttaagatagg aaaaaaaaat agtgggcaag gtgaacatca gacgtaaatt tgtgtgtttt     4980

tattttgtca tgctcttgaa aatgtttgac catttgtagt atacacagtg aaacttgatt     5040

ctctgttgca taaaacacta tatttttttg gaaatgttac tgtccaaaag cctcttccct     5100

ccctttcctt ttcctatgta cttccttcat acttgcttta ctgatcagcc aggcaatagc     5160

catccaagag ctagagcatg aaacagggcc ctttccaagt aggctctggg tgtcctaagc     5220

cagcgtgtgc cctctggttt agtgagtgta atagagtccc tggcaccttt ctttgcaaat     5280

gaggctaaca gaccagactg cagcaagtta tcagattcct caatcagatg cactaggagt     5340

gaggagccca gggatggagg gggttcctga agtattgcag ttggctgtag tagctgagtt     5400

cttttccatg ttaccgaaac tgtagccagt tacagtttac tcaggaaaac ggtagatcaa     5460

ttcagccatg gtagtgctgg ttggcaggga ttggtaacgg agagaactgc tcatcagcca     5520

aaactcaagc cttgcctttt aggaggccac cagcagaggg acttggtcct ccttgtctgg     5580

tacttgtgta catgccggtg acctgaggac tccactcaca ctggcgagca aaaagggagc     5640

agtgattctc ttttctctcc ccaccccctg ccctttgtta ccaacaccag tttcccaggg     5700

ggtacatgag tttctgaatt tttaaaaaat gtttttggtt tggtttttct ggggactgat     5760

aagtgcttta agcaatgtcc ataccccgtc aagactccca gcttagtcat tttcttgtat     5820

ttttctgttc acagtatttg tgtgtgtgct tgttttggca gctcattttg gctgtattat     5880

atattgagtg atgaattgat cctctttttt ccctaaggga tatgaattgt ttttcttgtg     5940

ttatattctg cttgtgaata gctggagcaa acctggggct gacacgcgta agctagggct     6000

gcaaagcgag aagagagccg gtggagtgta cttgtccctg acaggctgac ctacctgagt     6060

ctctgagctt ttcagtccaa atctttgcaa ggctcaaaat gccacagaac ctctcctctt     6120

ctccccactc cccatggcag ggaccggacc atccctacat gcaacatgct gttcctccag     6180

cccctcccat tgccatggca aaacaggtac ctttggggca tgggggcatt acatgggatg     6240

cttgtgtaat cgaccaccta gccttctctc tcccctcccg tcctccccca gaatcacttc     6300

ctaggacacc cgagctgctt gcccagggtc ctgtttccct gctaactcca gagaagcatc     6360

ccagggcttt gtgacagtct ctaattccct tcccttctcg ttaagaatca tattgtatag     6420

tagctttcag accatacagt attcattggg ttactcctat tattatcaag tagctggaat     6480

tgtgaaggtc ggagtagtta gatctttagc ttttattcct tatttttttg tattactctc     6540

catgtgtata aattattgat catgttgctg gcttttataa actctaagcg aaggaggagc     6600

actgcctcag cctttgcaca tggtaatgaa gcactgtttt taaataaaag agagaaacac     6660

c                                                                     6661


<210> 1159
<211> 3938
<212> DNA
<213> Homo sapiens

<400> 1159
agctgctggc ccccctgggt ccagaggagc cttgccgccc tcacctgcgc agagcctgga       60

gccgacgcgt cacccccagc ggaagcgcct cgctgcccgg gcgtctggcg aggtgtgcgc      120

tccgggtccc agctccagcg cttcgcggca gtcgcccgcc tctttccgca agcagggcgg      180

ggactgggcg gcatctaccg agatctgcga ttcgaggcgc cgaggagccg aagaccacag      240

ctcagctcag acggcgccct agggccgcac agagggtcgg gcagtgccgg agagaggttt      300

gaaagcgccg ccgccaactc gacagcgcgt cccagcgcct tgagctcgct tcctcctgct      360

ctcaggaaaa actgaggaaa cgcgcctggt tccaggggtc ggcggggacc gtggagacgc      420

tgccagcatc ctcaacagct tggaaatccc atcaccttgg ttccctgaga cttggaggac      480

tagtaggaac tgacagctgg ctgacagaaa acttatccag ggagagaaga gacaaaagtg      540

aagtgtgaaa ttttgaataa tgttttcaga tgctttgcat tcagaataga cctctgagtt      600

gggacccaag ctgtcaactg atcccaaatt cctaagttcc tgacttgcag gtattgagtt      660

ctaacctccg aagatggatg aaggtatgga aatttcaagt gaaggaaatt ccttgatcaa      720

agcagtccat cagagccggc ttcgcctcac aagacttttg ctagaaggcg gtgcctacat      780

taatgagagc aacgaccgtg gggaaacccc tttaatgatc gcttgtaaga ccaaacatgt      840

cgatcaccag agtgtcagta aagccaaaat ggtgaaatac ctgttagaga acaatgccga      900

tcccaacata caggacaaat ctgggaaaac ggctctgatg catgcttgct tagaaaaagc      960

tggccctgaa gttgtttcct tgctcctcaa gagtggggct gacctcagct tgcaagacca     1020

ttctagttac tcagctcttg tttatgctat aaattcagaa gatacagaga ccctgaaagt     1080

tcttcttagt gcttgcaagg caaaagggaa agaggtcatc atcatcacaa cagcaaagtt     1140

gccctgtggg aagcatacta ctaaacaata cttaaatatg cctcctgtgg atatagatgg     1200

gtgtcattcc ccagctacct gcaccactcc ttcagaaata gacatcaaaa ctgcctcatc     1260

gccactttca cattcttctg aaacggaact gacgcttttt ggctttaaag atcttgagct     1320

tgctggaagc aatgatgata cctgggaccc aggttcccct gtgaggaaac ctgcattggc     1380

ccctaagggg cccaagctcc cccacgctcc accctgggtc aagagtcccc cattattaat     1440

gcaccagaac agagtggctt cattgcaaga ggagctccag gatattacac cagaggaaga     1500

actatcctat aaaaccaatg ggctggcact ttccaagcgg ttcatcacta ggcaccaaag     1560

cattgatgta aaagacactg cacatttgct aagagccttt gatcaggcca gctcaaggaa     1620

gatgtcatat gatgaaataa attgtcaatc ttatctttca gaaggaaatc agcaatgcat     1680

tgaagtccct gttgaccagg acccagattc taaccagaca atatttgctt ccaccttaag     1740

aagtatagtt caaaaaagaa acttgggggc aaatcactac agctctgatt cccagctctc     1800

agctggcctt acccctccaa cttcagaaga cggcaaagca cttataggaa agaaaaagat     1860

cctctcacca tctccttccc aattgtcaga gtccaaagaa ttgttggaga atatcccccc     1920

aggtcccctg agcaggagaa atcatgcagt tttagaaagg cgaggttcag gagctttccc     1980

tttagatcac agtgttaccc aaaccagaca agggtttctc ccacccttaa atgtaaattc     2040

tcaccctccc atctcagata tcaatgtcaa caacaagatt tgcagccttc tttcttgtgg     2100

tcaaaaagtg cttatgccaa cagttccgat tttccctaaa gaattcaaaa gtaagaaaat     2160

gttgttaagg agacaatcat tgcaaactga acaaattaag caattagtaa acttctagga     2220

gatgggtata aaacacatct tcttcaaatg tttatatcag agaaacaaag aactagagaa     2280

gaaatcttaa atgttcattc ttttaaatct cgtgattggt tagtccataa tggctagatg     2340

gattaaaatg taatgtgatt tgtactaggc gtcatgagca taaaaaataa tacatagttt     2400

ctgttaaggg aattctctca aacaaaagga aagcgatttt tctcaatgct tctaatattt     2460

aacaatctcc atgtagtcca aatttgtcat taaaaaaaaa tcaaagaaag aaggccacgt     2520

atgttggggt aatttttaaa aattttcaga ttggctaaat attttattag gaaacagttt     2580

tcaagtcaat aattttttta acatttcatg ttaataaatg agattgaaat tttttatgat     2640

ctctaaacca taaaagaaaa caccgacagc tgtaaaatgt tctaagataa aaaaactcga     2700

gctacaaaga aagaatgaac taattcttta caaatgttga ctgaagatag ataaaactct     2760

aattaaaaat ttaaaaggtt aaacactgta ttagaatggg caactaaaat attcgtggtg     2820

tcagtttaat tagtgtcaaa ctggcaagtc agagttttac aacctactag taatctatgc     2880

cgggtcttgt tgtttgtgca ctgtgttttg ctttgctttg ttttggtttt taaacagact     2940

tacctgtaaa gttatcttac ggaattattc tttctccata tcttttaagg aattattctt     3000

tctccatatc atcttttaat tcctgttatt agttttggaa gcttatccat aagtttccaa     3060

agacaagatg atataaaagt taaaaagcat tcctctttac ttatatcaaa ttattcttgt     3120

ctttcaaaaa gaaccaaaaa aaaaaaattc atcatggata aaaactaagc gcttgccttc     3180

ttttaaaaag aaaaactgat gattagatta ggttagctaa aattaataga ggcagtagaa     3240

acttaatcac aaaatgtact aaatatttgg caatattaaa caatgccttt ttatttctga     3300

tatgtagtta ttagacattt atatattaag gataacttcc ttagtgtgac attccaatca     3360

tttagtattt taggacctgt gaataacttc caacaaaatt aatgaatacc atattagtat     3420

tataaaatat tataaagtaa taattatatc atctatataa cttcaaagta tgatgtttat     3480

acaaagaatc cttatttcag tctagcagct taacaacaaa ggataaatca gactatacaa     3540

aacctaagtg tattaatttg atgattgtca cgtacaactt tctttgcctt ccaagtagag     3600

gtgatcctaa caattggcat gatgcttttc ttggtaattt gatataagca agttgtaatg     3660

tacatagtaa ttatttaatt actgtggctt ttattttaaa aagtaattag aggtttttcc     3720

atttcatgtc ttgaacaaca ttaatattaa ttacactaga aatatttttt gattcagaac     3780

ttagaattgt acctgatatt tataggtatt taaatgcttt ctgcaagtta aatatcgaga     3840

aaagtacttg acttcaagtt gtaaggatac aatttggaag ggtatgtaaa tagattagtt     3900

cataaacaaa atggtatcaa taaagatttt aaatatca                             3938


<210> 1160
<211> 2441
<212> DNA
<213> Homo sapiens

<400> 1160
aggagggtga ggggcgggcc cagcgagcgg acgccgggcg cggcggcgcg cggagaagtg       60

cggcggagcg gcgcctgcat tagcaggtat gcaaagaagc cttttcaccc tgatgtcctt      120

agagataata tggatcagtc cagagttctc ctctgggtga aagcagaacc ctttatagtg      180

ggtgccttgc aggtcccccc tccatccaag tttagtcttc actatctcag gaagatatcc      240

acctatgtgc aaatccgggc cacagaagga gcttacccgc gcctctactg gtctacatgg      300

aggcacatcg cttgtgggaa gctgcagttg gccaaggacc tggcgtggct ttacttcgaa      360

atatttgata gtctttcaat gaagacacct gaggagcgcc tggaatggtc tgaggttctg      420

tccaactgca tgtctgagga ggaagttgaa aagcagagaa atcagctttc agtggacacg      480

ctacagtttc tgctcttctt atacattcaa cagttgaaca aggtctccct aaggacatct      540

ttgattggcg aagagtggcc cagtcccaga aacaaatctc agtctcctga cctgactgaa      600

aaatctaatt gtcataataa gaactggaat gattacagtc accaagcttt tgtctatgat      660

catctgtctg atctcctcga gctgctttta gatccaaaac aactcactgc atcatttcat      720

tcaacccata gtagtctagt gtctcgagaa gctgttgtgg cgctcagctt ccttattgaa      780

ggtacaataa gtagagccag gaagatctat ccacttcatg aacttgcact gtggcaacca      840

ctgcatgcag atagtggctt ctcaaagatc tctaagactt tctctttcta caaactggaa      900

acctggttga ggtcctgttt gactgggaat ccatttggta catcagcttg cctcaagtct      960

ggaaagaaat tggcttgggc tcatcaagtt gaagggacca ccaaaagagc taagattgct     1020

tgtaatactc atgtggcccc taggatgcac cgactggtag tgatgagcca ggtttacaag     1080

cagacactgg ctaagagctc agacactctg gcgggggcac atgtaaagat tcatcgttgc     1140

aacgaatctt ttatatatct gctctctccc ttacgatctg tgacaattga gaagtgcagg     1200

aatagcatct ttgtcttggg ccctgtaggg actacacttc acctccacag ttgtgacaat     1260

gttaaagtca ttgctgtttg ccatcgtttg tccatctctt ctacaacagg ttgcatcttt     1320

cacgttctta cgcctacacg cccacttatt ctctctggga accagacagt aacttttgcc     1380

ccttttcata cacattaccc aatgctagag gaccatatgg ccaggactgg ccttgctaca     1440

gtgcctaact attgggataa tccaatggtt gtgtgcagag agaacagcga cacaagagtc     1500

ttccagcttt taccaccttg tgaattctat gtatttatta ttccctttga aatggaaggg     1560

gacacaacag agatacccgg gggtcttcca tctgtatatc agaaagcact gggtcaaaga     1620

gaacagaaga tacagatctg gcagaaaact gtgaaggagg ctcatttgac aaaggatcaa     1680

aggaagcagt tccaggtact ggtagagaac aagttttatg aatggttgat taatacagga     1740

catcgccaac agctggacag ccttgtaccc cctgcagcag gctccaaaca agcagctgga     1800

taaggatctt acatgcagac actgggccct ggaaatacaa ggataaatgg aggatggtgc     1860

tcatcttgaa acttgaaact aaattgggaa ggtgctattg ctgcttaaga gacattggga     1920

cttttctgtc tttttttttt tttttttttg aggcagagtc ttgttctgtc gcccaggctg     1980

gagtgcagtg gcgcgatctc ggctcactgc aagctctgcc tcccgggttc acgccattct     2040

cctgcctcag cctcctgagt agctgggact acaggcgccc gccaccacgc ccggccaatt     2100

ttttttgtat ttttagtaga gacggggttt caccgtgtta gtcaggatgg tctcgatttc     2160

ctgacctcgt gatccgccca tctcggcctc ccaaagtgct gggattacag gcgtgagcca     2220

ccgtgcccag ccttctgttc tatttaagaa ctttgatttc cattccattt tcatttatta     2280

ctgtttaggc cgaattttcg ctaaacttct gactttcata taaacatatt gcttatagaa     2340

catcagaaga ctcgtctttg tgatgcccaa atgaaaaagt tggtgaaggt agtaccattg     2400

tatgtatgtt aatattaaag caactgagtg tagatttgca a                         2441


<210> 1161
<211> 855
<212> DNA
<213> Homo sapiens

<400> 1161
ggcggtgcgt tcttctacac atgcgcaggg ttgggcgggt cttcttcctt ctcgcctaac       60

gccgccaaca tggtgttcag gcgcttcgtg gaggttggcc gggtggccta tgtctccttt      120

ggacctcatg ccggaaaatt ggtcgcgatt gtagatgtta ttgatcagaa cagggctttg      180

gtcgatggac cttgcactca agtgaggaga caggccatgc ctttcaagtg catgcagctc      240

actgatttca tcctcaagtt tccgcacagt gcccaccaga agtatgtccg acaagcctgg      300

cagaaggcag acatcaatac aaaatgggca gccacacgat gggccaagaa gattgaagcc      360

agagaaagga aagccaagat gacagatttt gatcgtttta aagttatgaa ggcaaagaaa      420

atgaggaaca gaataatcaa gaatgaagtt aagaagcttc aaaaggcagc tctcctgaaa      480

gcttctccca aaaaagcacc tggtactaag ggtactgctg ctgctgctgc tgctgctgct      540

gctgctaaag ttccagcaaa aaagatcacc gccgcgagta aaaaggctcc agcccagaag      600

gttcctgccc agaaagccac aggccagaaa gcagcgcctg ctccaaaagc tcagaagggt      660

caaaaagctc cagcccagaa agcacctgct ccaaaggcat ctggcaagaa agcataagtg      720

gcaatcataa aaagtaataa aggttctttt tgacctgttg acaaatgtat ttaagccttt      780

ggatttaaag cctgttgagg ctggagttag gaggcagatt gatagtagga ttataataaa      840

cattaaataa tcagt                                                       855


<210> 1162
<211> 1415
<212> DNA
<213> Homo sapiens

<400> 1162
gtgacgggga ggcggtgccc ggggcatctc cgcggcggaa ctcagctgtg agaagtcact       60

gctttgggga gacctgatct ggctgtgcca gatggacact gagaaagaag tagaagactc      120

agaattagaa gaggaacatg gagctgatcc aggacacctc ccgcccgcca ctggagtacg      180

tgaagggggt cccgctcatc aagtactttg cagaggcact ggggcccctg cagagcttcc      240

aagcccgacc tgatgacctg ctcatcaaca cctaccccaa gtctggcacc acctgggtga      300

gccagatact ggacatgatc taccagggcg gcgacctaga gaagtgtaac cgggctccca      360

tctacgtacg ggtgcccttc cttgaggtca atgatccagg ggaaccctca gggctggaga      420

ctctgaaaga cacaccgccc ccacggctca tcaagtcaca cctgcccctg gctctgctcc      480

ctcagactct gttggatcag aaggtcaagg tggtctatgt tgcccgaaac ccaaaggacg      540

tggcggtctc ctactaccat ttccaccgta tggaaaaggc gcaccctgag cctgggacct      600

gggacagctt cctggaaaag ttcatggctg gagaagtgtc ctacgggtcc tggtaccagc      660

acgtgcagga gtggtgggag ctgagccgca cccaccctgt tctctacctc ttctatgaag      720

acatgaagga gaaccccaaa agggagattc aaaagatcct ggagtttgtg gggcgctccc      780

tgccagagga gaccatggac ttcatggttc agcacacgtc gttcaaggag atgaagaaga      840

accctatgac caactacacc accgtccccc aggagctcat ggaccacagc atctccccct      900

tcatgaggaa aggcatggct ggggactgga agaccacctt caccgtggcg cagaatgagc      960

gcttcgatgc ggactatgcg gagaagatgg caggctgcag cctcagcttc cgctctgagc     1020

tgtgagaggg gctcctggag tcactgcaga gggagtgtgc gaatctaccc tgaccaatgg     1080

gctcaagaat aaagtatgat ttttgagtca ggcacagtgg ctcatgtctg caatcccagc     1140

gatttgggag gttgagctgg taggatcaca ataggccacg aatttgagac cagcctggta     1200

aaatagtgag acctcatctc tacaaagatg taaaaaaatt agccacatgt gctggcactt     1260

acctgtagtc ccagctactt gggaagcaga ggctggagga tcatttcagc ccaggaggtt     1320

gtggatacag tgagttatga catgcccatt cactacagcc tggatgacaa gcaagaccct     1380

ccctccaaag aaaataaagc tcaattaaaa taaaa                                1415


<210> 1163
<211> 7179
<212> DNA
<213> Homo sapiens

<400> 1163
cttcctcatt ggcgccgtgc agagaggcgg aatgttcaac tcctaactgc agcggaaacg       60

tgggagccgc gcgggccgct gtcgtcccaa cccccgccgc cctcgtcgcg cgcggggcct      120

ccgcgccccc ggctgctgct cacgccccgc ccgggagcca gattttgtgg aagtataata      180

ctttgtcatt atgagatgtc gtctctcggt gcctcctttg tgcaaattaa atttgatgac      240

ttgcagtttt ttgaaaactg cggtggagga agttttggga gtgtttatcg agccaaatgg      300

atatcacagg acaaggaggt ggctgtaaag aagctcctca aaatagagaa agaggcagaa      360

atactcagtg tcctcagtca cagaaacatc atccagtttt atggagtaat tcttgaacct      420

cccaactatg gcattgtcac agaatatgct tctctgggat cactctatga ttacattaac      480

agtaacagaa gtgaggagat ggatatggat cacattatga cctgggccac tgatgtagcc      540

aaaggaatgc attatttaca tatggaggct cctgtcaagg tgattcacag agacctcaag      600

tcaagaaacg ttgttatagc tgctgatgga gtattgaaga tctgtgactt tggtgcctct      660

cggttccata accatacaac acacatgtcc ttggttggaa ctttcccatg gatggctcca      720

gaagttatcc agagtctccc tgtgtcagaa acttgtgaca catattccta tggtgtggtt      780

ctctgggaga tgctaacaag ggaggtcccc tttaaaggtt tggaaggatt acaagtagct      840

tggcttgtag tggaaaaaaa cgagagatta accattccaa gcagttgccc cagaagtttt      900

gctgaactgt tacatcagtg ttgggaagct gatgccaaga aacggccatc attcaagcaa      960

atcatttcaa tcctggagtc catgtcaaat gacacgagcc ttcctgacaa gtgtaactca     1020

ttcctacaca acaaggcgga gtggaggtgc gaaattgagg caactcttga gaggctaaag     1080

aaactagagc gtgatctcag ctttaaggag caggagctta aagaacgaga aagacgttta     1140

aagatgtggg agcaaaagct gacagagcag tccaacaccc cgcttctctt gcctcttgct     1200

gcaagaatgt ctgaggagtc ttactttgaa tctaaaacag aggagtcaaa cagtgcagag     1260

atgtcatgtc agatcacagc aacaagtaac ggggagggcc atggcatgaa cccaagtctg     1320

caggccatga tgctgatggg ctttggggat atcttctcaa tgaacaaagc aggagctgtg     1380

atgcattctg ggatgcagat aaacatgcaa gccaagcaga attcttccaa aaccacatct     1440

aagagaaggg ggaagaaagt caacatggct ctggggttca gtgattttga cttgtcagaa     1500

ggtgacgatg atgatgatga tgacggtgag gaggaggata atgacatgga taatagtgaa     1560

tgaaagcaga aagcaaagta ataaaatcac aaatgtttgg aaaacacaaa agtaacttgt     1620

ttatctcagt ctgtacaaaa acagtaagga ggcagaaagc caagcactgc atttttaggc     1680

caatcacatt tacatgaccg taatttctta tcaattctac ttttattttt gcttacagaa     1740

aaacgggggg agaattaagc caaagaagta tatttatgaa tcagcaaatg tggtgcctga     1800

ttatagaaat ttgtgatcct atatacaata taggactttt aaagttgtga cattctggct     1860

ttttctttta atgaatactt tttagtttgt atttgacttt atttccttta ttcaaatcat     1920

ttttaaaaac ttacattttg aacaaacact cttaactcct aattgttctt tgacacgtag     1980

taattctgtg acatactttt tttttcttat agcaatacac tgtaatatca gaaatggttg     2040

gcctgagcaa cctagtaaga cctcgtctct actaataatt aaaaaactag ctggcatggt     2100

agcacacacc tgtagtccca gatacttggg aggccaaggc aggaggattg cttgagacct     2160

agcaatcagt cagggctgca gtgagccatg atggcaccac tgcactctag cctgggcaag     2220

agaacaagat cctgtctcaa aaaacaaaaa aaagaaagaa ttgatagtac aaaatccaac     2280

aacaatactg agatgatcta agaaggttat aacaaaatgc tcttcagaaa tacctaagtg     2340

ctgagaattt ttagtactaa agagcacagc tgctcaaagt aaagcctgag cagtgttctc     2400

agtaatgtat ttgaaggaaa aataccctga tttgaaacca acagcagatg ttgcaaactt     2460

tcataccact gctggccatg gaagcctctt aacaacacac tgtcatttaa ggctgtgctt     2520

gtgctttata caaagagaaa gaggtggtct taaggggatg cttccagggg ggtgagttca     2580

tgcctctcct gtattttcca gcaagtgggg tatgtgtggt ggtttgtttt ttagaggggc     2640

ataataatcc aggattctaa gcatatgctc agctatttta aagaggaaat taaatattat     2700

aaaagaaata gtaaagataa gttatcctca cttaggcaaa agcacaggtc ctttccatat     2760

caagtttagc ctaccagggt tgttttttgt tttaaccctg cttaataatg ttggtgtttt     2820

agaagtagat acaggcactg ctctgaaaac ctggctagcc aaggatattc tcagaatgtt     2880

atcacctgtt tgtcaaagct tgtttaaatt ataaaacact tttaattata tatatgaggc     2940

aaaagaacta agactttttt caaactaaat tagaaaggag tgtcattatt tgactgttaa     3000

accaaaatat ttttggtggg tctttttatg gaagtttaaa gaaaggacat catcatagat     3060

atgatctaac agtatttcta actatatttg atcattaaaa gcctcttgga atttgaagcg     3120

tgacgtgttt ctaatgcccc ttgagaggtg aaaaatacca cataatgatc agtatgctgt     3180

gccagcttca tttggggaga aataactagt agaaagttct gggtgtgagg tgtacagcag     3240

tctaggtggc atagtgatga agaaagggat cagagtctga ctgtcactca gaatcctggg     3300

ctcagttgct tgacaacctt gggaaaattg ttttatcttt gtgcgtctgt ttgctgatct     3360

tcagcgtggg aataataaca gtacctactt gaaaggatca ttgtgcggat taaaagaaat     3420

aatatatgta aagcacttta acacagcacc aggcccacgg aaagtggcta atgttagcta     3480

ctatgaatgg tgccagtgaa gacactgaaa aataagtgat ttcagtaacc ttctggaaag     3540

ctatcagttt caaataatat tttctctgta gtatgagatg aaattaaaag tggatagctt     3600

tcaggaaaga taaagagaac atgcttagaa tgtaagctaa acagattttt tctgttgctc     3660

tttgaaaact atgagccctg gccagcttaa cctggtctga ggtgagacta aacacaaaaa     3720

cagtagataa atctctccct aaaagatgga ttcccccaca tacccatgct actagtttct     3780

ctgtctattc acacatatgt acaaatacat gaacacagcc tgtctgtgct cagacataga     3840

gaagtactac ctgacttgag tcaatgcacc caagaagaaa agcttggagt agagcagaag     3900

ggagggcttg ggactcctgt ctttccagca tgccctgggg tgcagtggtc agccacctga     3960

agagagagcc aatagcatgg ggtttacaag gcaaagatag tcattcattc aacacatatt     4020

catagagctc cttctctgtg ccagacactg ttctggaaga tagctagatg aaaatctttg     4080

cactcacaga gcttacatgc cagtgagtga agatcgatga taaataaagc aaatgcatca     4140

tatgttcaca tttgataagt atatgccaaa aaatgaagcc gggaaggagg acaaggccca     4200

tgggtgggtg ttgaggtttt taaagtgtgg tcaggaaagg ccccactgat aaggtaacat     4260

ttgagcaagt ctgaaaaagg caaggggatc tttggggcta acttcgggat ccctgcactt     4320

tatgtaagaa tgtaaacctg gagtctcatt taagaatgat cagcaatacg tttagaacat     4380

atgaactgaa tgaaatggac attttttctt aatttatgta taaatccata tgattataca     4440

taaagttctg atgcattaat aaaagcagcc aaatagggcc aaagagaaaa ataacaggac     4500

tctgtactgg acctaacttt atcattaatt aggtaatatt ttcctcattt ctttactgct     4560

gccattttcc tcaccagtat tccagagatg gtcatagctc attactctac caccaagaac     4620

ctaaaaggaa ttagaataca gcagaattgg cctcagtgaa gagcttaaaa ttgttctcct     4680

cgtagaactg gactattgat cattaccacg tgacgttggc tctattactt tctgttccca     4740

atgtccttct agtggtttga aaatgttaaa acatccctaa aatctaaatc atataatcag     4800

aattctatag tgtcccactc tatctgtaaa gatcatttgg aagactttag actctattaa     4860

ttttaaaagg aatatttatt agccatatgc agaatttcta atgatgatat tgtacagctt     4920

ctaattcact tttcagatca gtgtttgaaa tggcaattat cagtgttgga tttagttcca     4980

actacttgat ttacaaaaat gtacatttag aggttaaaag aaacagtgag aaatgtaaac     5040

attcaaaatg ataattgaat ctctcagttg tgggaataat tatcagagac atgcaactga     5100

aaatgtctca cctttcatct ttttttctta attcataaag ttatcttgta gaatttgatg     5160

agaccctccc tagtcattct caactggggc ggtgctgtca ccgaatggtg tttgagagtg     5220

ttggggctag ggcacatttt tggttgtcac agcaactggg gtggcatttg ctgcccagtg     5280

ccaggaatag taacattatg aatgccaggg acagtgtgct cagtaaagtc ttccatccaa     5340

aaggggcagg gcacggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggtggg     5400

cggatcacct gatgtcaggg gttcgagacc agcctggcca acatggtgaa accctgttgc     5460

tactaaaaat acaaaaattg gctgggtgtg gtgtcacatg ccagtaaccc cagctactag     5520

ggaggctgag gcaggagaat cacttgaacc cgggaggcag aggttgcagt gagctgagat     5580

tgcaccacta cactccagcc tggatgacag agtgagactt catctcaaaa aaaaaaaaaa     5640

acaaaaaaaa acaacccggt agcattgtcc cttccccact gacaaactta tcaaatccag     5700

aagctttaga gtttcgtctc taattatttt tctcctgaac aaaattaccc aagtcaaaac     5760

aaaatgtatt tttagaatta cggcagcata cgacctgaat tttgtgagtt tcgtggcttt     5820

atcttaaatc accatttccc taaaaatggt ttctttctcc ttagaaatgc tggtggcaac     5880

ttgatgaaac agccaaatgc accagggcag gtcactttcc cattacactg attccacaat     5940

taaaaaaaaa aaagaaaaaa aactcattga gatagctaca gttctatagg ttaatttaaa     6000

gcctcctttt tctactcatt tttgaaagca aaattacatt ttactatttt acataaccag     6060

tgaaaagacg ttgaaagcct acagctcact gtttttggtg ctctggaaat gttgagggtg     6120

ggtttttaac cagtgatttt taacgtgcag tgaatttgtt agacttttaa acaccagcta     6180

aggtagtcaa acttgatccc cattaaaaat caaggaatta ggggtcgggg gagggtttag     6240

gagtgatcca gaatgacctc ccagaattac tgtgcgtaca actttatttt tcagagtttt     6300

cattggaatg gtaagagttt tatgaaagac agttttaaaa cttattctga gttaaatatt     6360

aatactttaa aaaattattg tactagactt attgcagcct tttgaaagta gcagagtttc     6420

atcataccac atatataaca gagcataaat tttctataat caggcacctt ttgctgcttt     6480

tgagtaagac tgttttcctg tttaagtgtt aagcatcgcc agacataaaa atctattctc     6540

tcctctcgat tgtagcatag cctgacagct ctagatacag catttctatg atgaaaaatg     6600

agtatccatc aggaaatcta gaagactagc cgtgttttct cagactccac ctttgtttgc     6660

actctgttgc ctgtgaggag ctttctggca tgtgattatt tacttcaaaa ctagagttcc     6720

aagcacctac attaattatt ttatattgtg tgcagaatag tatatctttt aatgtcagat     6780

atgatacact gcacatattg cttttgcact cttaaaattt ttgtactaaa taatagaaaa     6840

tatttatatt ctttgagtgt gagctttgaa tagatggcat tatcacttta ttgttttttt     6900

aacaaaaact ttttctcaat tattctattg caatgttatt ctgagcaagt cctatgccaa     6960

atatcttgta taatgtttgt atggaagatt aaattttact cttgtgtggt aagactattt     7020

cagttactga ttttatagtt ggaatttgat attccagcac aaagtccaca gtgtattcag     7080

aaatccaagt tggtgtcata catttcattt tgatgtgaac ttttctttgc tttcctttgt     7140

tctaagactc cattttgcaa taaacgtttt gacagtaaa                            7179


<210> 1164
<211> 705
<212> DNA
<213> Homo sapiens

<400> 1164
ctggcttctt ggcgcgatga ggttccggtt ctgtggtgat ctggactgtc ccgactgggt       60

cctggcagaa atcagcacgc tggccaagat gtcctctgtg aagttgcggc tgctctgcag      120

ccaggtacta aaggagctgc tgggacaggg gattgattat gagaagatcc tgaagctcac      180

ggctgacgcc aagtttgagt caggcgatgt gaaggccaca gtggcagtgc tgagtttcat      240

cctctccagt gcggccaagc acagtgtcga tggcgaatcc ttgtccagtg aactgcagca      300

gctggggctg cccaaagagc acgcggccag cctgtgccgc tgttatgagg agaagcaaag      360

ccccttgcag aagcacttgc gggtctgcag cctacgcaaa ctgaagcagg cccagaccct      420

gatgagctcc ctgggctgag gagaagggtg ttccaggcct gtgtggagcc gccctgcccg      480

tatggagtca cgccctctga actgctcttc gggaggcagc cctggttcta ggatgctgag      540

gccctggccc ggactctggc ctcccagatc cccagctgcc tcacttctct cttgagaact      600

tggctcaggg ctcctgagga cctttcccag cattaccttc ccttcccttg aaaggcaatt      660

gttggctgtt ttcataagca ggaaaaataa acagaagtat aaagg                      705


<210> 1165
<211> 882
<212> DNA
<213> Homo sapiens

<400> 1165
ggtggccgat agctggtcct ctttctccaa cacctagcct gagacttggc ggcgcggctg       60

ctatcctgaa ctagcttggt aagtgttgtg tcccgaacca gcgtagagag acctcggacc      120

agccgccttg atgacagcat ccgcgtcctc cttttcatca tctcagggtg tccagcagcc      180

ctccatctac agcttctccc aaataaccag aagcttgttt ctcagcaatg gtgtggccgc      240

caacgacaaa ctccttctgt ccagcaatcg catcaccgcc attgtcaatg cctcggtgga      300

agtggtcaac gtattcttcg agggcattca gtacataaag gtgcctgtta ccgatgctcg      360

tgactcgcgt ctctacgact tttttgaccc cattgctgat cttatccaca ccatcgatat      420

gaggcagggc cgtacgctgc tgcactgcat ggctggagtg agccgttccg cctcactgtg      480

ccttgcgtac ctcatgaaat accactccat gtcgctgctg gacgcccata catggaccaa      540

gtcgcgccgc cccatcatcc ggcccaacaa cggcttttgg gaacagctca tcaattacga      600

attcaagctg tttaataaca acaccgtgcg catgatcaac tcgccggtag gtaacatccc      660

tgacatctat gagaaggacc tacgtatgat gatatcaatg taagccatcc cggccagccc      720

ctgacatctg ccatcgatct tgcaccaaga ctgaacttga acactgacat tttgttagta      780

aagaaaaccg gatggtgcct tgttaaaggg caagaaaaaa gggagggggt tggagttttg      840

aacgtagtaa gccttacctt aatagaatta aattcatgaa ac                         882


<210> 1166
<211> 4189
<212> DNA
<213> Homo sapiens

<400> 1166
ttgggggatg ccgacgcctg ggccttgagg atgctgcgga agctcaccat cgagcagatc       60

aacgactggt tcaccatcgg caagacggtg accaatgtgg agctgctggg cgcgccgccc      120

gccttcccgg caggggcggc cagggaggag gtgcagcgcc aggacgtggc ccccggcgct      180

ggtcccgcgg cccaggctcc ggctctggcc caagctccgg cccggccggc cgctgcgttc      240

gaaaggtcac tcagccaaag gagctcagaa gtagagtata ttaacaaata cagacagctc      300

gaagcacaag agcttgatgt gtgtcgcagt gtccaaccaa ccagtgggcc aggtccaagg      360

ccatctttgg ctaaattaag cagtgtgaca tgcatcccag ggacaactta taaatatcct      420

gatttgccta taagtcgata caaggaagag gttgtgtctt tgatagaaag taattccgtg      480

gtgattatcc atggggccac gggaagcggt aaaagcactc agctcccgca gtatatcttg      540

gaccactacg ttcagcgctc cgcctactgc agcattgtgg tcacccagcc ccggaagata      600

ggggcaagca gcatcgccag gtggatcagt aaagagcgtg cctggaccct gggaggtgtg      660

gtgggctacc aggtagggct agagaaaata gcaacagagg acaccaggct aatttatatg      720

acaactggag tcctgcttca gaaaatagtt agtgccaaga gtttgatgga attcacacat      780

atcatcattg atgaagtaca cgaacgaaca gaagaaatgg atttcctgct attggtagtc      840

cgcaaactct taagaacaaa ttcacgtttt gtgaaggtgg tcctgatgtc ggctaccatc      900

agctgtaaag agtttgcaga ctactttgct gttcctgttc aaaacaagat gaatcctgca      960

tatatttttg aagtggaagg caagccccat tcagttgaag agtattatct taatgatttg     1020

gagcacattc atcatagcaa gctctctcct catctcctgg aggaaccggt gataactaag     1080

gatatatatg aagttgctgt ctctctcatt cagatgtttg atgacttgga tatgaaggag     1140

agtgggaaca aggcttggtc gggggcccag tttgtgttgg agcgaagcag tgtgttggtg     1200

tttttgccag gtctgggtga aataaattat atgcatgaac ttctcacaag cctggttcat     1260

aaaaggttgc aggtctatcc actccattca agtgtggctt tagaagaaca gaataatgtc     1320

tttttaagtc cagtccctgg gtacagaaag attattctgt ccaccaatat tgcagagagt     1380

tctgtcacag ttccagatgt caaatatgtt atagattttt gtttgactag aactttggtc     1440

tgtgatgaag atacaaatta tcagagtctg cgattgagtt gggcttctaa aaccagctgt     1500

aatcagagaa aaggccgtgc tggacgagtg tctagagggt actgttaccg gctggtacac     1560

aaggatttct gggacaactc catccctgat catgttgttc ctgagatgtt gcgttgtcca     1620

ttaggaagca cgatcttgaa agtgaaatta cttgacatgg gtgagccgag agctctgctg     1680

gccactgccc tttccccgcc tggtctgagt gacattgagc gcaccatcct tctactaaag     1740

gaggttggag cacttgcagt gagtgggcag agagaagatg aaaaccccca tgatggtgaa     1800

ttgaccttct taggaagagt tttagcccaa cttcctgtaa atcagcaact tggtaaactc     1860

atagtccttg gacatgtatt tggatgtcta gatgaatgtc ttattatagc ggcagctctt     1920

tctttgaaga atttttttgc aatgcctttc cggcagcatc tcgatggata taggaacaaa     1980

gtgaatttct ctggcagtag caagagtgac tgtattgcac ttgttgaggc atttaaaaca     2040

tggaaggctt gcagacagac aggggagctg cggtacccga aggatgaact taattgggga     2100

cggttaaatt acattcaaat caagagaatt agagaggtgg ctgaattata tgaagaattg     2160

aagactagaa tctcacagtt caacatgcat gttgattctc ggcgacctgt catggaccaa     2220

gagtatatat ataagcagcg attcatccta caggttgtat tggcaggtgc tttctatcca     2280

aattacttta cttttggaca gccggatgag gagatggcgg tgagggagct ggctggcaag     2340

gaccccaaga caactgtcgt gttgaaacac attcctccct atggatttct ttactataaa     2400

caactacagt ctctctttag acagtgtggt caagtcaaat ccattgtatt tgatggtgca     2460

aaagcctttg tggaattctc acgaaatcca acagagagat ttaaaaccct tcctgcagta     2520

tatatggcaa ttaagatgtc tcaactaaaa gtttcacttg aactcagcgt tcattctgca     2580

gaggaaattg aagggaaggt gcaaggcatg aacgtctcaa agctcaggaa cacaagggtg     2640

aatgtggact tccagaagca gacggtagat cctatgcaag tctcctttaa cacatcagac     2700

aggtcccaga cagttacaga tctccttcta actattgatg tcacagaggt ggttgaagtg     2760

ggacactttt ggggatacag gattgatgaa aacaactcag agattctgaa aaagcttact     2820

gctgaaatca accaactgac gctggtgccc ttgcccactc acccacatcc agacttggtc     2880

tgtctggcac cttttgctga ttttgataaa caacgctact ttagagctca agtcctttat     2940

gtttctggaa attctgctga ggtattcttt gtagattatg gcaataagtc tcatgtagat     3000

ctacatcttt tgatggagat tccctgtcaa tttcttgaac ttcctttcca ggctttggaa     3060

tttaagattt gcaaaatgag accatcagca aagtctcttg tttgtggcaa gcactggagt     3120

gacggggcca gccagtggtt cgcctctctg gtgagcggct gcaccctcct tgtgaaggtc     3180

ttctctgtgg tgcacagcgt cctgcacgtg gatgtgtacc agtactcagg ggtccaggat     3240

gccatcaaca taagagacgt cctcatccag cagggctatg ccgagctcac ggaggagtcc     3300

tacgagtcca aggttaatat tctcagggct gctattaaca agctagtctg tgatggacca     3360

aatggatgca agtgtcttgg gccagagaga gttgcgcagc ttcaagacat tgcccgtcag     3420

aagcttttag gtttgttctg tcagtcaaaa ccaagggaga agattgttcc caagtggcat     3480

gaaaagccct acgagtggaa tcaggttgat ccaaagctgg tcatggagca ggccgaccgt     3540

gagagcagca gagggaagaa cacctttctc taccagctcc acaaactggt tgtgctcggc     3600

acctgagcat gtccacaggt ggcctccagc acacccctca ggaagctgtg gaggctggat     3660

tccaggctcc ctccgcagac tgactttcct ctgtgtctgg gtgttacagt ctgtgcccac     3720

tgcatcctaa aggccttttc tttcttcttt tctctttggg tgatagtcag agagtggtgt     3780

ttttgttcag gtgggaagga ttggaaactc tagtcttttc tagaaacaga aaatcactgt     3840

attaaatatt ttggaaagat tgttctgaaa gaagtctgtt tggataaaga gctgtatttt     3900

gctttaaatt tattaaggta aatataagta gttaatctta gatgtaaggt tccagaatgt     3960

gcttacatat tctgttctgt tacagtgatt taaaccagta gtataggaaa aaacttaaaa     4020

aaacaaaaaa accatgtagt attttctgat ttttttttcc atgagggaaa atatctaatt     4080

tttataagac taagttgagt tatacttctt ggttcacatt ttggaaatca gagattacag     4140

attacatggc catagcttat ctgtgttaaa acaataaaag cattaaatg                 4189


<210> 1167
<211> 987
<212> DNA
<213> Homo sapiens

<400> 1167
acagttgaag aagcgaccga gggactggga gtcgttagtg aggatgacgc ggcatggcaa       60

gaactgcacc gcaggggccg tctacaccta ccacgagaag aagaaggaca cagcggcctc      120

gggctatggg acccagaaca ttcgactgag ccgggatgcc gtgaaggact tcgactgctg      180

ttgtctctcc ctgcagcctt gccacgatcc tgttgtcacc ccagatggct acctgtatga      240

gcgtgaggcc atcctggagt acattctgca ccagaagaag gagattgccc ggcagatgaa      300

ggcctacgag aagcagcggg gcacccggcg cgaggagcag aaggagcttc agcgggcggc      360

ctcgcaggac catgtgcggg gcttcctgga gaaggagtcg gctatcgtga gccggcccct      420

caaccctttc acagccaagg ccctctcggg caccagccca gatgatgtcc aacctgggcc      480

cagtgtgggt cctccaagta aggacaagga caaagtgctg cccagcttct ggatcccgtc      540

gctgacgccc gaagccaagg ccaccaagct ggagaagccg tcccgcacgg tgacctgccc      600

catgtcaggg aagcccctgc gcatgtcgga cctgacgccc gtgcacttca caccgctaga      660

cagctccgtg gaccgcgtgg ggctcatcac ccgcagcgag cgctacgtgt gtgccgtgac      720

ccgcgacagc ctgagcaacg ccaccccctg cgctgtgctg cggccctctg gggctgtggt      780

caccctcgaa tgcgtggaga agctgattcg gaaggacatg gtggaccctg tgactggaga      840

caaactcaca gaccgcgaca tcatcgtgct gcagcggggc ggtaccggct tcgcgggctc      900

cggagtgaag ctgcaagcgg agaaatcacg gccggtgatg caggcctgag tgtgtgcggg      960

agaccaaata aaccggcttg ggtgcgc                                          987


<210> 1168
<211> 2074
<212> DNA
<213> Homo sapiens

<400> 1168
gccgggccgg agcggggtgg gtaggggacg cgaggcggag cggggcccca cacaggccgc       60

ggcggctggc tcgggcccct acggtcccgg cggcggctgg aggaggaagc caggcggctg      120

gcggaggagg agagacggag gaggccgaga ccggagcgcc gctcgccgca gacttacttc      180

cccggctcag cagggaaagg ttcctagaag gtgagcgcgg acggtatgca aagttgtgaa      240

tccagtggtg acagtgcgga tgaccctctc agtcgcggcc tacggagaag gggacagcct      300

cgtgtggtgg tgatcggcgc cggcttggct ggcctggctg cagccaaagc acttcttgag      360

cagggtttca cggatgtcac tgtgcttgag gcttccagcc acatcggagg ccgtgtgcag      420

agtgtgaaac ttggacacgc cacctttgag ctgggagcca cctggatcca tggctcccat      480

gggaacccta tctatcatct agcagaagcc aacggcctcc tggaagagac aaccgatggg      540

gaacgcagcg tgggccgcat cagcctctat tccaagaatg gcgtggcctg ctaccttacc      600

aaccacggcc gcaggatccc caaggacgtg gttgaggaat tcagcgattt atacaacgag      660

gtctataact tgacccagga gttcttccgg cacgataaac cagtcaatgc tgaaagtcaa      720

aatagcgtgg gggtgttcac ccgagaggag gtgcgtaacc gcatcaggaa tgaccctgac      780

gacccagagg ctaccaagcg cctgaagctc gccatgatcc agcagtacct gaaggtggag      840

agctgtgaga gcagctcaca cagcatggac gaggtgtccc tgagcgcctt cggggagtgg      900

accgagatcc ccggcgctca ccacatcatc ccctcgggct tcatgcgggt tgtggagctg      960

ctggcggagg gcatccctgc ccacgtcatc cagctaggga aacctgtccg ctgcattcac     1020

tgggaccagg cctcagcccg ccccagaggc cctgagattg agccccgggg tgtgctaaag     1080

aggcagtaca ccagtttctt ccggccaggc ctgcccacag agaaggtggc tgccatccac     1140

cgcctgggca ttggcaccac cgacaagatc tttctggaat tcgaggagcc cttctggggc     1200

cctgagtgca acagcctaca gtttgtgtgg gaggacgaag cagagagcca caccctcacc     1260

tacccacctg agctctggta ccgcaagatc tgcggctttg atgtcctcta cccgcctgag     1320

cgctacggcc atgtgctgag cggctggatc tgcggggagg aggccctcgt catggagaag     1380

tgtgatgacg aggcagtggc cgagatctgc acggagatgc tgcgtcagtt cacagggaac     1440

cccaacattc caaaacctcg gcgaatcttg cgctcggcct ggggcagcaa cccttacttc     1500

cgcggctcct attcatacac gcaggtgggc tccagcgggg cggatgtgga gaagctggcc     1560

aagcccctgc cgtacacaga gagctcaaag acagcgccca tgcaggtgct gttttccggt     1620

gaggccaccc accgcaagta ctattccacc acccacggtg ctctgctgtc cggccagcgt     1680

gaggctgccc gcctcattga gatgtaccga gacctcttcc agcaggggac ctgagggctg     1740

tcctcgctgc tgagaagagc cactaactcg tgacctccag cctgcccctt gctgccgtgt     1800

gctcctgcct tcctgatcct ctgtagaaag gatttttatc ttctgtagag ctagccgccc     1860

tgactgcctt cagacctggc cctgtagctt ttctttttct ccaggctggg ccgtgagcag     1920

gtgggccgtt gagttacctc tgtgctggat cccgtgcccc cacttgccta ccctctgtcc     1980

tgccttgtta ttgtaagtgc cttcaatact ttgcattttg ggataataaa aaaggctccc     2040

tcccctgccc ctcagcttct ctctggtttt ctca                                 2074


<210> 1169
<211> 946
<212> DNA
<213> Homo sapiens

<400> 1169
gctccagaga ggggaaggaa ggggcagcag agaggggtca gaaggaggga gcttaagcca       60

ggcagggtta cttgtctctg tgactccttc cgcctggcac atgctgccca gctatgggga      120

cctttgacct gtggacagat tacctgggtt tggcacacct ggttagggct ctgagtggga      180

aagagggtcc tgaaaccagg ctgagccccc agccagagcc agagccaatg ctggagccgg      240

tgtcagccct ggagccgatg ccagcgccgg agtcggtgcc agtgccggga cccaaggatc      300

agaagcgcag cctggagtcc tcgccagctc ccgaacgcct gtgctctttc tgcaaacaca      360

acggcgagtc ccgggccatc taccagtccc acgtgctgaa ggacgaggct ggcagggtgc      420

tgtgtcccat cctgcgggac tacgtgtgtc cccagtgcgg cgccacacgt gagcgcgccc      480

acacccgacg cttctgccca cttactggcc agggctacac ctccgtctac agccacacca      540

cccgaaactc ggcaggcaag aagctggtcc ggcctgacaa ggcgaagaca caggacacag      600

gccaccgccg aggaggagga ggaggagcag gtttcagagg tgccgggaag tctgagcctt      660

cgccctcctg ctctccctcc atgtccacct aggaggctgc ctacacctgg gcaagggcac      720

ccgggctcgg ctggatttcc aggaagaccc accctatgac gactgccccc actcccagac      780

cctcccccca gcctgggatt gagccctggg gatgacccgg ggttggcaag ggaagagctg      840

aaatcgccct gtccttgggg accccaccct ttgtgccatc tgccgtttcc ctagtgctgg      900

gcatccagtc agccctcaat aaatgcttat gaatggatca acaaca                     946


<210> 1170
<211> 2669
<212> DNA
<213> Homo sapiens

<400> 1170
ctctcccggt gtgggtactg ctgtctgtgg tgtggctgtg ggacccgtga gcaagcagcg       60

acgccagcgg cggagaaccg acgaaaggtg tcaccacagt gatggcagtg gaggacagca      120

cgctgcaagt agtggtacgg gtgcggcccc ccacccctcg ggagctggac agtcagcggc      180

ggccagtggt tcaggtggtg gacgagcggg tgctggtgtt taaccctgag gagcccgatg      240

gagggttccc tggcctgaaa tggggtggca cccatgatgg ccccaagaag aagggcaaag      300

acctgacgtt tgtctttgac cgggtctttg gcgaggcggc cacccaacag gacgtgttcc      360

agcacaccac gcacagcgtc ctggacagct tcctccaggg ctacaactgc tcagtgtttg      420

cctacggggc caccggggct gggaagacac acaccatgct gggaagggag ggggaccccg      480

gcatcatgta cctgaccacc gtggaactgt acaggcgcct ggaggcccgc cagcaggaga      540

agcacttcga ggtgctcatc agctaccagg aggtgtataa tgaacagatc catgacctcc      600

tggagcccaa ggggcccctt gccatccgcg aggaccccga caagggggtg gtggtgcaag      660

gactttcttt ccaccagcca gcctcagccg agcagctgct ggagatactg accaggggga      720

accgtaaccg cacgcagcac cccactgatg ccaacgcgac ttcctcccgc tcccatgcca      780

tcttccagat ctttgtgaag cagcaggacc gggttccagg actgacccag gctgtccagg      840

tggccaagat gagcctgatt gacctggctg gctcagagcg ggcatccagc acccatgcga      900

agggggagcg gctgcgggag ggggccaaca tcaaccgctc tctgctggcg ctcatcaacg      960

tcctcaatgc cttggccgat gcaaagggcc gcaagaccca tgtgccctac cgggacagca     1020

aactgacccg cctgctcaaa gactccctcg ggggcaactg ccgcacagtg atgatcgctg     1080

ccatcagccc ctccagcctg acctacgagg acacgtacaa caccctcaaa tatgccgacc     1140

gggccaagga gatcaggctc tcgctgaaga gcaatgtgac cagcctggac tgtcacatca     1200

gccagtatgc taccatctgc caacagctcc aggctgaggt agccgctctg aggaagaagc     1260

tccaagtgta tgagggggga ggccagcccc caccacagga cctcccagga tctcccaagt     1320

cgggaccacc accagaacac cttcccagct cccccttgcc accccaccct cccagccagc     1380

cctgcacccc agagctccct gcagggccta gagcccttca agaggagagt ctggggatgg     1440

aggcccaggt ggagagggcc atggaaggga actcttcaga ccaggagcag tccccagagg     1500

atgaggatga aggcccagct gaggaggttc caacccagat gccagagcag aaccccacac     1560

atgcactgcc agagtcccct cgcctgaccc tgcagcccaa gccagtcgtg ggccacttct     1620

cagcacggga actggatggg gaccgttcta agcagttggc cctaaaggtg ctgtgcgttg     1680

cccagcggca gtactccctg ctccaagcag ccaacctcct gacgcccgac atgatcacag     1740

agtttgagac cctacagcag ctggtgcaag aggaaaaaat tgagcctggg gcagaggcct     1800

tgaggacttc aggcctggcc aggggggcac ctctggctca ggagctgtgt tcagagtcaa     1860

agcctccagg atacactggc cctgtgaccc ggactatggc gaggcgactg agtggccccc     1920

tgcacaccct gggaatcccg cctggaccca actgcacccc agcccagggg tcccgatggc     1980

ccatggagaa gaagaggagg agaccaagcg ccttggaggc agacagtccc atggccccaa     2040

agcggggcac caagcgccag cgccagtcct tcctgccctg cctaaggaga gggtctctgc     2100

ctgacaccca accttcacag gggcccagca cccccaaagg agaaagggcc tcctccccct     2160

gccattcccc tcgcgtttgc ccagccacag tcatcaaaag ccgggtgccc ctgggccctt     2220

ccgccatgca gaactgctcc accccgctgg ctctgcccac tcgagacctc aatgccacct     2280

ttgatctctc tgaggagcct ccctcaaagc ccagtttcca tgaatgcatt ggctgggaca     2340

aaatacccca ggagctgagc aggctggacc agcccttcat ccccagggca cctgtgcccc     2400

tgttcaccat gaagggcccc aagccaacat cttccctccc tgggacctct gcctgcaaga     2460

agaagcgcgt tgcgagttcc tcagtctccc atggccgcag ccgcatcgcc cgcctcccca     2520

gcagcacttt gaagaggcca gctgggcccc ttgtactccc agagctgccc ttgagtcccc     2580

tgtgccctag caaccggagg aatggaaagg acctcatcag ggtggggaga gcactctcag     2640

cagggaacgg cgtcaccaag gtgtcctga                                       2669


<210> 1171
<211> 1065
<212> DNA
<213> Homo sapiens

<400> 1171
agcagtcttt gaaacagctg taacggcatc tgtgaaagaa gataggttcc aggaacggaa       60

ctgccactta gattgtaaat tcctgaaaaa caggacgttt ttgcatctcc tcccggcttc      120

cccatcccta aaccaacgtc tgttgaatta aactaccaaa caaaataact gcagtacagc      180

aatggcgatc agaaggtaga acagctgtat ggctgcacat tcccatcctc caaagccgat      240

ttattgcccc tgctgcttcc ctgggcttct gctttcacca cgcagaatcg gattcatcaa      300

cgttgactct gtggctgaga gaagggccca gcagattacc aggatatgct tcacatcaag      360

taggagttgc aggagctgta tttgatgaaa gtactagaaa aatactggtt gtacaagatc      420

gaaataaatt gaaaaatatg tggaagtttc caggaggcct gtcagagcct gaagaagata      480

ttggagacac agcggttcga gaagtttttg aagagactgg tataaaatca gaattcaggt      540

ccgtcctgag tattcggcaa cagcacacaa atcctggagc ttttgggaag tcagatatgt      600

atatcatctg ccgcctaaag ccatattcat tcaccataaa tttttgccag gaagaatgct      660

taagatgtga gtggatggat ctcaatgacc tggcgaagac tgaaaataca actcccatca      720

ccagcagagt tgctaggctg ctgctgtatg ggtacagaga agggtttgac aaaattgacc      780

tgactgtgga agaacttcca gcagtttaca caggactgtt ttataaactc tatcataagg      840

aactgccaga gaattataaa actatgaaag gaattgatta aattcacatt tatatgttta      900

gaaacatgta gactaacgaa tgacataaga aatagtggac attttggatt gattaaacat      960

ctgactgtga ttttctaatg tatatgattt ccatgaagaa attttgtttc taaacatgca     1020

cattttaaaa gcctcttttc gaataaagca aatgcgtgaa aaaga                     1065


<210> 1172
<211> 7552
<212> DNA
<213> Homo sapiens

<400> 1172
tgtttgaccc ggaagtggct gtgttcagct gacagctgct gataaggtgg cggcggcgaa       60

ggcagcggca ggtcgggagc aagatggcgc tgcggccagg agctggttct ggtggcggcg      120

gggccgcggg agctggcgcg gggtccgccg ggggaggcgg cttcatgttt cctgttgcag      180

gtgggataag accccctcaa gcaggcctga tgccgatgca gcaacaagga tttcctatgg      240

tctctgtcat gcagcctaat atgcaaggca ttatgggaat gaattacagc tctcagatgt      300

cccaaggacc tattgctatg caggcaggaa taccaatggg accaatgcca gcagcgggaa      360

tgccttacct aggacaagca cccttcctgg gcatgcgtcc tccaggccca cagtacactc      420

cagacatgca gaagcagttt gccgaagagc agcagaaacg atttgaacag cagcaaaaac      480

tcttagaaga agaaagaaaa agacgccagt ttgaagagca gaagcaaaag ctcagacttt      540

tgagcagtgt gaaacccaag acaggagaga agagtagaga tgatgctttg gaagccataa      600

aaggaaattt agatgggttt tccagagatg caaaaatgca ccctactcca gcatcgcacc      660

ccaagaaacc aggtgtggga gtatttccct cacaggatcc tgctcagccc agaatgcctc      720

cttggattta caatgagagt ttggttccag atgcctataa gaaaatctta gaaaccacaa      780

tgactccaac tggaatagat actgccaaac tgtatcccat tctgatgtca tctgggcttc      840

ccagggaaac tcttggacag atatgggcct tagctaatcg aactacacct ggcaaactta      900

caaaagaaga actttatacc gttctagcca tgatagcggt aacacaggta gtaaagccag      960

aagaagatga cttccaggat tttcaagatg cttctaagtc aggatccctt gatgactcat     1020

tcagtgattt ccaagagttg cctgcttctt caaaaacaag taactcccag catggaaaca     1080

gtgccccttc tttgttgatg ccacttcctg gaactaaagc attgccttca atggacaaat     1140

atgctgtgtt taaaggaatt gcagctgaca agtcctctga aaatactgtt ccacctggag     1200

atcctggtga taaatatagt gctttcagag aacttgaaca gacagcagag aataaacctt     1260

taggagaaag ctttgcagaa ttcagatctg caggaactga tgatggtttc accgatttta     1320

aaacagccga tagtgtatca ccactagagc caccaacaaa agacaaaact tttccaccat     1380

ccttcccctc aggaactata caacagaaac aacaaacaca agtgaaaaac cctctgaact     1440

tagcagacct agatatgttt tcctcagtta attgcagcag cgagaaacca ttgtcttttt     1500

cagctgtgtt tagcacatca aaatcagttt ctacaccaca gtcaacaggt tctgctgcta     1560

ctatgacagc attggcagca acaaaaactt ctagtttggc tgatgatttt ggagaattca     1620

gcctttttgg ggaatattct ggtctagcac ctgttgggga gcaggatgac tttgcagatt     1680

ttatggcttt cagtaatagc tctatttcat ctgagcaaaa gccggatgac aaatatgatg     1740

cccttaaaga ggaagccagt cctgttcctc taaccagcaa cgtgggcagc acagtgaagg     1800

gtggacaaaa ctcgactgct gcgtctacca agtacgatgt cttcagacaa ctttctctgg     1860

aagggtctgg actaggtgtt gaagacctga aagataacac tccttcagga aaaagtgatg     1920

atgattttgc tgacttccac tccagtaaat tttcttccat aaactcggac aaatccctgg     1980

gagagaaagc agtggctttc agacacacca aagaagactc tgcatcagtg aagtccttag     2040

atctcccttc cattggtggc agcagtgttg gcaaggagga ctctgaagat gcactctctg     2100

ttcagtttga catgaaattg gctgatgtgg gaggagatct taagcatgtc atgtctgata     2160

gctctttgga tttaccaaca gttagtggcc agcatcctcc tgctgcagca ggaagtggat     2220

ccccctcagc cacctcaatt cttcaaaaga aagagacttc atttggcagt tctgaaaaca     2280

tcaccatgac atctctctcc aaagtaacga cctttgtaag tgaagatgct cttccagaga     2340

ccaccttccc agctcttgcc agttttaaag acacgattcc tcagaccagt gagcaaaagg     2400

aatatgaaaa cagagactat aaagatttca caaaacagga cctgcctacg gctgaacgga     2460

gccaggaggc cacgtgtccc agcccagcgt ccagtggtgc ctctcaagaa accccgaacg     2520

aatgttcgga tgactttgga gagtttcaaa gtgaaaagcc caaaatcagc aaatttgact     2580

tcttagtagc cacttcacaa agcaaaatga aatccagtga agaaatgatc aaaagtgagc     2640

tggcaacctt tgacctttct gttcaaggat cacacaagag gagtttgagc cttggtgata     2700

aagaaataag ccgttcttct ccttctccag ctttggagca gcctttcaga gaccgttcca     2760

atactctgaa tgagaagccc gccctgcccg tcatccgaga caagtacaaa gacctgacgg     2820

gagaggtgga ggaaaatgag agatatgcat atgaatggca gagatgcctg gggagtgccc     2880

tgaatgtcat taagaaggca aatgatacct taaatggaat cagtagtagt tctgtttgca     2940

cagaagtaat tcagtcagct caaggcatgg aatatttatt aggtgttgtt gaagtgtaca     3000

gggtaaccaa gcgtgtggag ctggggataa aagccactgc agtgtgcagt gagaaactcc     3060

agcagttgct gaaggacatc gataaagtat ggaataacct aatcggcttc atgtcactcg     3120

ccacactcac accagatgaa aactcgctgg atttttcctc ctgtatgtta cggcctggga     3180

ttaaaaatgc tcaggagctt gcctgtggag tgtgcctctt gaatgtggac tcgaggagcc     3240

ggaaagaaga gaagcctgca gaagaacatc ctaaaaaagc attcaactca gaaacagaca     3300

gtttcaagct ggcctatgga gggcaccagt atcacgccag ctgtgccaac ttctggatca     3360

actgtgtcga accaaagcct cctggcctcg tcctgcctga cctgctctga acaactcctc     3420

tgtgaagcat tgactttttt ttttctgtga caccccacgg ggtgacaggg accaataaat     3480

agaatgcgag cactgcacag ttcgcttccc tgaatcgata tgaagaacac cgcaagggac     3540

ggggcccccg tcatccccac ggccagtctg caggacttca ggtaaaattg tcccacccaa     3600

actgcacgtg gcaccagaag cttgctcact tatctctact taagattttc tgaaatacgg     3660

accacggctt tcttgatcta aggaagaact tgctgctgca gtattgaaac tgtgaagaac     3720

tgacatttga agaaaaatag attaccgttg cgggactaga atgggcgact gcttggagcc     3780

agtgcttgtt tttatctagg acacttactg tcctgtgaag tagaatacat ttatctgcat     3840

ttagtttgtt aatgtctgaa atgaataaaa agaggaaatt gcgattaaac tgatgttctg     3900

ctttttatgg agaagattct gcccatctcc cctggacagt agcaggcagg tgagggcaga     3960

ttttacccac ttggttgtca caactgaacc agttctctac tccttccctt cacttctgtc     4020

cactctcaag actttttccc aaaacatgcc tgggcactct gcagccgtga agaatgctca     4080

ttttgacaga ggcccaaatc ctgtgtatta ggataatatc cttccccccg ggagccttcg     4140

ctgcaaacct gttctgccgc atgcaaagac tgtgaccatg gagttttctc agacaagatt     4200

tggaaaggca gtggaatgaa atctctttgc agtggcctct ctccaaattt ccaaagatga     4260

ctgcataggg accaacactg cctgactttg cagtatctgt gagaaaaacc tgaaaattaa     4320

ttcagggtga aaatgtggag ctctcggcct agtgtaaagt atcaagatgt atatttatgg     4380

gatagataca tgacttagaa gaagtagaag aaaattgtcc agaaacagta ctgaatttta     4440

gatagaaaag gctcatgctt cctggagtag ggaattgtct ttgccattta atgtgaatgc     4500

ataaaattag gggaaaaacc caagtggcta agagctgtgt tattcctggg aagaactacc     4560

aatctagggc acacgtctct ctgaattgtt gattatgcgc tttatgaaga gatttttcaa     4620

tctcgtgtgc tttactttgt gtggtttaga ccctctgacc tagactttta tttttaaact     4680

gaaaaagttg gtcttgtcta tataattgct gcttttacat aatttatttt cccctctcag     4740

gacaaattct gtcttgctcc atcttacagc ttttccatgt tctccaagaa aggtgtggaa     4800

cattttcatt aaacagctgt tgctgaggct tctgcttgac cttctgcgtg cccgaatgca     4860

cagagaggca ccgaggagag aaaggctttt ctcactcgct cccgatgata ccgtctctgg     4920

ccattcctga ctgaggcagc tcactctgaa tgggcacctt tggagctttt gcccaccaca     4980

aggctagtgg ggtgtttcta acaacacaag tgggacagct tttggcaggc ttttcctgag     5040

gcctcggcgc ttccatcctg gacagcacca cttccacatg gagctggaat gcaagcaggc     5100

tgctaattgg ccttaaaaat tctttgtttt tttttgagat ggagtttcac tcttgttgcc     5160

caggcttgag tgcaatggca caatctcagc tcagtgcaac ctccgcctcc cgggttcaag     5220

cgattctcct gcctcagcct cgtgagtagc tgggattaca ggcgtgcacc accacgccca     5280

gctaattttg tatttttagt agaggcaagg tttctccatg ttggccaggc ttgaactccg     5340

gacctcaggc gatccgcccg cctcagcctc ccaaagtacc gggattacag gcgtgagcca     5400

ctgcgcctgg cctaaatttc ataacagaac catgacagca gaatctacct ttgcaataag     5460

aatgtttccc aggagttaga gaccagccct gggcatgatg gtaaagaccc cagctaatta     5520

tacaaaaaat aattagccgg gtaggtggag tgcatctgtg gacattcgtg gtcccagcta     5580

ctaggtaagc tgaggcggga gatcacaagt ccaggagttt gaggctgcac gtgacagcgt     5640

aggtgatgac agagcgagac actgtctctt aaaaaaaaaa aaaaaaaagt ttcccagttt     5700

gaatttgtat tgctgaagca tttttttgaa atgctatata gatgcctgtc atgtcacagt     5760

ggcccagtat caacatttta aaaagctcac ttggtagctg ggctggtttc tattcctgag     5820

aaattccaga atgcctcaga taaaattcct tagtataatc cccattttcc ttaccaagga     5880

tggtaggctt agtcactcct tgggaggtgc cacaggaaaa ttcagcagat gtcaacagaa     5940

aaaaagcctt tgctatgaaa agtattcact acctttcata tctcttgaat acttgaaatg     6000

tttaattaga tgccaccaat agggatccaa ggagtgtggg acacggttgc gctgcttttc     6060

tttataaacg tttattaaaa tggctcaacg ctgcattcag cttcacctca gctcttcttg     6120

tcagccagga gccccgtgtc cttggaaact gtagccaagg ttacttattt ccatactgtg     6180

cattgtgtca gcccgcttca ccccactgct tgaatggcca ttaataagca cttttctttt     6240

tttggtggga tgttttgcct ttaaaatttt tatggcttag tgtgtaattt aatttttgtc     6300

tggacatgct tgagatagaa gaggtactgg atatatgagg atattttcca tgctttattt     6360

ttcctgtggc tactagttag cattccatag gggttgtgaa tttttaatta tttgaatatt     6420

ttgtgtacat atacatattt gaagggtttt gggggggtct tatttgttta aaggtgtctt     6480

ctgtttgcct atttcaagtg tacttcagct ttgcaaagat tatagggctg tatgttacag     6540

aaataggaaa tgctggccct gtactgggga ccactacaaa aattcccttt agccgggcgt     6600

ggtggctcac gcctgtaatc cccagcactt tgggaggccg agccgggtgg atcacccgag     6660

gtcaggagtt caagaccagc ctggccaaca tggcgagacc ctgtctctac taaaaataca     6720

aaaattagct gggcatggtg gcaggtgcct gtaatccgag ctactcggga ggctgaggca     6780

ggagaattgc ttgaaccaga gaggcggagg ttgcagtgag ccgagatcgc gccactgcac     6840

tccagcctgg gcaacaagag cgaaactctg tctcaaaaat aaaaaattcc ctttaacacc     6900

ttcaaggtca aatgcctgcc tttgtgaaca gttaataaac tgacattttc agacatttgc     6960

cattcagaag ggagcattgt agcctgctgt agaccattcc agcaaatgtc agaatgcagg     7020

gcaagatgtg tgtcgactat gttttttatg tttaagttac ttacttattt cttcaggtaa     7080

gtgtgtacca aataacaata ctgaaaagcc ctccccttgc caggccgagg aaataaagct     7140

taagtgaaac agctcttggg ggaaaaatgc cactttacaa atacttttct aacaaaatag     7200

cattataatg aagtttttac ttaattccat tatttatatg ttgacgtgaa tgtaagtggt     7260

taaaaagtat tcatgtggga catctcatta ctttgtagct gtggctttat taaccagtga     7320

atgctgtggc ccttagcgaa atgcgttgtc ttctgcgtga tgtggaattc gcgcctgtat     7380

tttaaaagat ggtgtggttt ctcccttgtt tgtattttaa taaacaactg ctctaattga     7440

tgtgtttaga cattataaag cttcaccttt aaaatatttt cagggtctgt tctgaaatca     7500

ccccttgtta aacttctcta accaaaatac aagtgtagaa gaatgtcagg ct             7552


<210> 1173
<211> 2111
<212> DNA
<213> Homo sapiens

<400> 1173
ggcggcggct ggggagaagc gctctcgtcg cctgcccgag gccggagcgg cggggcccgc       60

gcctcctccc cccagcgccg cggagggggg aggaggaaga tggagaccca catctcatgc      120

ctgttcccgg agctgctggc catgatcttc ggctacctgg acgtccggga caaggggcgc      180

gcggcgcagg tgtgcaccgc ctggcgggac gccgcctacc acaagtcggt gtggcggggg      240

gtggaggcca agctgcacct gcgccgggcc aacccgtcgc tgttccccag cctgcaggcc      300

cggggcatcc gccgggtgca gatcctgagc ctccgccgca gcctcagcta cgtgatccag      360

ggcatggcca acatcgagag cctcaacctc agcggctgct acaacctcac cgacaacggg      420

ctgggccacg cgtttgtgca ggagatcggc tccctgcgcg ctctcaacct gagcctctgc      480

aagcagatca ctgacagcag cctgggccgc atagcccagt acctcaaggg cctggaggtg      540

ctggagctgg gaggttgcag caacatcacc aacactggcc ttctgctcat cgcctggggt      600

ctgcagcgcc tcaagagcct taacctccgc agctgccgcc acctttcgga tgtgggcatc      660

gggcacctgg ccggcatgac gcgcagcgcg gcggagggct gcctgggcct ggagcagctc      720

acgctacagg actgccagaa gctcacagat ctttctctaa agcacatctc ccgagggctg      780

acgggcctga ggctcctcaa cctcagcttc tgtgggggaa tctcggacgc tggcctcctg      840

cacctgtcgc acatgggcag cctgcgcagc ctcaacctgc gctcctgtga caacatcagt      900

gacacgggca tcatgcatct ggccatgggc agcctgcgcc tctcggggct ggatgtttcg      960

ttctgtgaca aggtgggaga ccagagtctg gcttacatag cccaggggct ggatggcctc     1020

aagtctctct ccctctgctc ctgccacatc agtgatgatg gcatcaaccg catggtgcgg     1080

cagatgcacg ggctgcgcac gctcaacatt ggacagtgtg tgcgcatcac ggacaagggc     1140

ctggagctga tcgctgagca cctgagccaa ctcaccggca tagacctgta cggctgcacc     1200

cgaatcacca agcgcggcct ggagcgcatc acgcagctgc cgtgcctcaa ggtactcaac     1260

ctgggactct ggcagatgac ggacagtgag aaggaggcac gaggggattt ttctccatta     1320

ttcactgtga gaactcgggg aagctccaga aggtgaggga gaggggacaa cgacatggtt     1380

cccgtggatc tttaacttcc agacttgccc gctctgcgcc tccggcactc tggtgatgac     1440

agctcaggtt tccctgcctg tcactgctcg ggcagaggct gctgcccagg gcttctgctc     1500

cggtaccttg tgaagctgca ttctcctgcc ggtttctcca gttctgggga cagtggtttg     1560

ctctgagacc tcgcttcctt tatggatcca aggagacttg ctttttcagt ctgttcagct     1620

ttttacttgc taggatggaa ttgcaatttg caagcttctt cgacaggaaa ctacaagttc     1680

cacactttaa ttttatacat ataaatatat acatgtgtac atatatctat gtacaggggt     1740

attatatata tacatataag atgatgatat atataatgat gatatgtatt actgagaacg     1800

taaaatatca ttacatagtg atagctggac acacaaggaa ttcacaactc cccaaagaaa     1860

atacatctgg atgacctgcc tagcagtttc cccatgagat agaggaatgt ctacgtattt     1920

cattccctgt tcctgccctg aaacaatttc aatcactgac aaatcattat cattcattaa     1980

taatgtttac tgagtgccca tatgtgaaag aaatccactc tacattccac agatgcattt     2040

cctctcccca cggggtttcc attttaatgg gaacaatgta gaatatatct gtcttccctt     2100

tatagattcc a                                                          2111


<210> 1174
<211> 1744
<212> DNA
<213> Homo sapiens

<400> 1174
ctcttgattt ctggggccgg tgaccaggcc caacgcagcc ttcaagtcgg cccaaacacg       60

gtttctgcct caaggattat ttatataacc attgcttatt ggctgctggc aaacactcgc      120

tcttctcgtt ggctgaaact gtcgggagaa gttctgcgaa ggctgctcct tgcggcgttg      180

ggactgaggg tcacaggcac ctgtatttcc gtttccggtt cgcctccgga gccatggcgg      240

cggcactgaa gtgtctactg acattaggaa gatggtgccc cggccttgga gtggctcccc      300

aggcccgggc gctcgccgcc ttagtacccg gagtgaccca ggtagataac aagtccggtt      360

tcctgcagaa gaggcctcat cgccagcacc ctggcatcct aaagctgccg cacgtgcggc      420

tgccacaggc actggctaac ggtgcccagt tattgctact tgggagcgct gggcccacta      480

tggagaatca ggtgcaaaca ctgaccagtt atctctggag cagacatttg cctgtagagc      540

cagaggagtt gcaaagacgg gctaggcatc ttgagaaaaa attcctggaa aacccagact      600

tatctcagac agaggagaaa cttcgtggag cagtgctaca cgcactacgt aaaactacct      660

accattggca agaactgagc tacactgagg gactgagcct ggtgtatatg gcagcaagac      720

tggatggtgg ctttgcagca gtctccagag cattccatga gatccgggct cgaaatccag      780

catttcagcc acaaactttg atggactttg gctcaggtac tggttctgtc acctgggctg      840

ctcacagtat ttggggccag agcctacgtg aatatatgtg tgtggacaga tcagctgcca      900

tgttggtttt ggcagaaaaa ctactgaaag gtggttcaga atctggggag ccttatattc      960

caggtgtctt tttcagacag tttctacctg tatcacccaa ggtgcagttt gatgtagtag     1020

tgtcagcttt ttccttaagt gaactgccca gcaaggctga ccgcactgag gtagttcaaa     1080

ccttatggcg taagacaggt catttcctgg tactggtgga gaatggaaca aaagctgggc     1140

acagccttct catggatgcc agggatctgg tccttaaggg aaaagagaag tcacctttgg     1200

accctcgacc tggttttgtc tttgccccgt gtccccatga actcccttgt ccccagttga     1260

ccaacctggc ctgtagcttc tcacaggcgt accatcccat ccccttcagc tggaacaaga     1320

aaccaaagga agaaaagttc tctatggtga tccttgctcg ggggtctcca gaggaggctc     1380

atcgctggcc ccgtatcact cagcctgtcc ttaaacggcc tcgccatgtg cattgtcact     1440

tgtgctgtcc agatgggcac atgcagcatg ctgtgctcac agcccgccgg cacggcaggg     1500

atttgtatcg ttgtgcccgt gtcagctcct ggggagatct tttacctgtg cttactccgt     1560

ctgcgtttcc tccatctacg gctcaggatc cctctgagag ttgatgagga tgtgtaacaa     1620

gtattttctt ctatcgtgcc tgccagggct gaagctgcct ggtatccagg aggggaatgc     1680

tggtatcccc atatgtctgt gtttgtttga gatttttaat aataaataat aaatttttga     1740

agaa                                                                  1744


<210> 1175
<211> 1463
<212> DNA
<213> Homo sapiens

<400> 1175
ctccgctccc gtgagtaact tggctccggg ggctccgctc gcctgcccgc acgccgcccg       60

ccacccagga ccgcgccgcc ggcctccgcc gctagcaaac ccttccgacg gccctcgctg      120

cgcaagccgg gacgcctctc ccccctccgc ccccgccgcg gaaagttaag tttgaagagg      180

ggggaagagg ggaacatgga catgaagagg aggatccacc tggagctgag gaaccggacc      240

ccggcagctg ttcgagaact tgtcttggac aattgcaaat caaatgatgg aaaaattgag      300

ggcttaacag ctgaatttgt gaacttagag ttcctcagtt taataaatgt aggcttgatc      360

tcagtttcaa atctccccaa gctgcctaaa ttgaaaaagc ttgaactcag tgaaaataga      420

atctttggag gtctggacat gttagctgaa aaacttccaa atctcacaca tctaaactta      480

agtggaaata aactgaaaga tatcagcacc ttggaacctt tgaaaaagtt agaatgtctg      540

aaaagcctgg acctctttaa ctgtgaggtt accaacctga atgactaccg agagagtgtc      600

ttcaagctcc tgccccagct tacctacttg gatggctatg accgagagga ccaggaagca      660

cctgactcag atgccgaggt ggatggtgtg gatgaagagg aggaggacga agaaggagaa      720

gatgaggaag acgaggacga tgaggatggt gaagaagagg agtttgatga agaagatgat      780

gaagatgaag atgtagaagg ggatgaggac gacgatgaag tcagtgagga ggaagaagaa      840

tttggacttg atgaagaaga tgaagatgag gatgaggatg aagaggagga agaaggtggg      900

aaaggtgaaa agaggaagag agaaacagat gatgaaggag aagatgatta agaccccaga      960

tgacctgcag aaacagaact gttcagtatt ggttggactg ctcatggatt ttgtagctgt     1020

ttaaaaaaaa aaaaaaggta gctgtgatac aaaccccagg acacccaccc acccaaagag     1080

ccaaagaata gttcctgtga cattccgcct tccttccatg tagtccctct tggtaatcta     1140

ccaccaagct tgtggacttc accccaacaa aattgtaagc gttgttaggt ttttgtgtaa     1200

gattcttgct gtagcgtgga tagctgtgat tggtgagtca accgtctgtg gctaccagtt     1260

acactgagat tgtaacagca tttttacttt ctgtacaaca aaaaagcttt gtaaataaaa     1320

tcttaacatt ttgggtctgt tttttcatgc tttgcttttt aattattatt attatttttt     1380

ttacattagg acattttatg tgacaactgc caaaaaagta tttttaagaa tttaagcgaa     1440

ataaacagtt actctttggt aaa                                             1463


<210> 1176
<211> 1668
<212> DNA
<213> Homo sapiens

<400> 1176
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc       60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag      120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc      180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc      240

gtgagattgc cacactccag gagcagctga tgacctcaga agccactgtc cacagcctgc      300

aggccaccgt gcaccagagg gacgagctca ttaggcagtt gcagccccgg gctgagctgc      360

tgcaggacat ctgccgccgc cggccacccc tggctgggct gctggatgcc ctggctgagg      420

ctgagcgcct ggggcccctg ccggccagtg accccggcca cccacccccc ggtgggcctg      480

gtccacccct tgacaacagc actggggaag aggcggacag ggaccacctc cagcctgcag      540

tgtttgggac cacagtgtga gcccggaatg cagattacag aatggagaca gaaagccact      600

gctgtcagtg tccttgggag tcaccagcac cctgcagggg gaccctacgg cagagccaaa      660

gtcctgtcta agcatcagaa caggctgaac agtcaaaaag ttttcaaata ggcccacagg      720

ccaggtgcag acgtttaacc cagacagaag tgttcttgtt tgtttttaag ctttgaatca      780

gtcacccttg ctaaaaacct ggcaatgcaa acacaaagat ctggatttct ggcaagactt      840

ggccaagctt gcctggagtt cagggcaccc tctttagcca gggtgtgagt ttctgttttt      900

tgtttttttt tttttaagac agagtcccac tctgtcgccc tggctggggt gcagtggtgc      960

gattttggct aactgcaacc tccgcctccc aggttcaagc gattctcctg tctcatcctt     1020

cagagtagct gggattacag gcgcccacca ccacacccgg atattttata tttttggtag     1080

agaccgggga ggggaggggg tttcaccatg ttgaccaggc tggtctcaaa ctcctgacct     1140

taggtgatcc acccgcctcg gccttcgaaa gtgctgcagt tataggtgta agccaccgcg     1200

cccggcccta gcctagcttt tgtagcatgc aactgtctcc tttttatacg ccctaaagaa     1260

tatatttttg aactccttgt ttctgcgctg tccttcttag cccaggacat tcagggtgct     1320

ttgcttgttg tcaaaccagg gaaaggagaa aactcctgtg cctttctggg ccagcctgtc     1380

accctggcct ggtcggcagc cattccccta cctcctcact caggaactgt cacaccagga     1440

accggcgagg ggcacagcct gtttcagacc agaaaggtcg gaggccaccc acggccttca     1500

ggatggcgcc cgcctgcctg cctggcaaca gtgacccctc agtgcagtaa caatgggccc     1560

attttctcct ctggatgaac aaggaggggg gttgtttgta caaaggaaag gcaggctggg     1620

gcctgtctgt gctcaagaat aaaccggatg atttcctggc ctgggggc                  1668


<210> 1177
<211> 2951
<212> DNA
<213> Homo sapiens

<400> 1177
ctttggggtt ctgtgtgcag cgagcatggt gtccttggca ccagggtttc ggcagaggag       60

cctagcgtgg gcctacttgg actcctccgc gtggggcagc tcgggacacc cgggcctgca      120

ggagagcggg gttctaggct ggccccggct ctgcagtgca gccgggtgcc tgccactcgc      180

ggggctctgt cgcagtactc gtgcctggcg cctcccctca gccacagaga ccgcagtagc      240

tccaaccatc gcacccctaa ctgggccacg agttctctga ttgccagacc tgttgtcttt      300

gccactcact gttctgagta attggagagt cgtgtattca ctacacgcca accagagtgg      360

tcctgtaaaa gcgtaagcct agtgtagata cgcttctgct taaaactctt gagtggctcc      420

cagtgctttt agaacaaaat ccaaacgcct ttccgaagtc gacaaggccc agcttgattg      480

agcagaagat gtgataggag atgaggagcg gggggcttct gcaaaagtgc ttcggtcgct      540

caggcttttg gcacattttg cttatgcaac ctagttcttt ctaccttagg gccttttctt      600

gggaaagttg ggagtctcac tctgctgcct aggctgagtg cagtggtgtg atcgaggcgc      660

actgcagcct tgacctcctg ggctcaagcg atcctcacct cggcctaccg agtagctggg      720

actacaggca cgcgccacta cactcggatt tctgacagtc agacttgtcc acaagaactc      780

aactggcaag gctgcttttc tgtgctaaaa ctggggagct agtgggcacc atgaagatct      840

tctgcagtcg ggccaatccg accacggggt ctgtggagtg gctggaggag gatgaacact      900

atgattacca ccaggagatt gcaaggtcat cttatgcaga tatgctacat gacaaagaca      960

gaaatgtaaa atactaccaa ggtatccggg ctgccgtgag cagggtgaag gacagaggac     1020

agaaggcctt ggttctcgac attggcactg gcacgggact cttgtcaatg atggcggtca     1080

cagcaggtgc cgacttctgc tatgccatcg aggttttcaa gcctatggct gatgctgctg     1140

tgaagattgt ggagaaaaat ggctttagtg ataagattaa ggttatcaac aagcattcca     1200

ccgaggtgac tgtaggtcca gagggtgaca tgccatgccg tgccaacatc ctggtcacag     1260

agttgtttga cacagagctg atcggggagg gggcgctgcc ctcctatgag cacgcacaca     1320

ggcatctcgt ggaggaaaat tgtgaggccg tgccccacag agccaccgtc tatgcacagc     1380

tggtggagtc cgggaggatg tggtcgtgga acaagctatt tcccatccac gtgcagacca     1440

gcctcggaga gcaggtcatc gtccctcccg ttgacgtgga gagctgccct ggcgcaccct     1500

ctgtctgtga cattcagctg aaccaggtgt caccagccga ctttacagtc ctcagcgatg     1560

tgctgcccat gttcagcata gacttcagca agcaagtcag tagctcagca gcctgccata     1620

gcaggcggtt tgaacctctg acatctggcc gagctcaggt ggttctctcg tggtgggaca     1680

ttgaaatgga ccctgagggg aagatcaagt gcaccatggc ccccttctgg gcacactcag     1740

acccagagga gatgcagtgg cgggaccact ggatgcagtg tgtgtacttc ctgccacaag     1800

aggagcctgt ggtgcagggc tcagcgctct atctggtagc ccaccacgat gactactgcg     1860

tatggtacag cctgcagagg accagccctg aaaagaatga gagagtccgc cagatgcgcc     1920

ccgtgtgtga ctgccaggct cacctgctct ggaaccggcc tcggtttgga gagatcaatg     1980

accaggacag aactgatcga tacgtccagg ctctgaggac cgtgctgaag ccagacagcg     2040

tgtgcctgtg tgtcagcgat ggcagcctgc tctccgtgct ggcccatcac ctgggggtgg     2100

agcaggtgtt tacagtcgag agttcagcag cttctcacaa actgttgaga aaaatcttca     2160

aggctaacca cttggaagat aaaattaaca tcatagagaa acggccggaa ttattaacaa     2220

atgaggacct acagggcaga aaggtctctc tcctcctggg cgagccgttc ttcactacca     2280

gcctgctgcc gtggcacaac ctctacttct ggtacgtgcg gaccgctgtg gaccagcacc     2340

tggggccagg tgccatggtg atgccccagg cagcctcgct gcacgctgtg gttgtggagt     2400

tcagggacct gtggcggatc cggagcccct gtggtgactg cgaaggcttc gacgtgcaca     2460

tcatggacga catgattaag cgtgccctgg acttcaggga gagcagggaa gctgagcccc     2520

acccgctgtg ggagtaccca tgccgcagcc tctccgagcc ctggcagatc ctgacctttg     2580

acttccagca gccggtgccc ctgcagcccc tgtgtgccga gggcaccgtg gagctcagaa     2640

ggcccgggca gagccacgca gcggtgctat ggatggagta ccacctgacc ccggagtgca     2700

cgctcagcac tggcctcctg gagcctgcag accccgaggg gggctgctgc tggaaccccc     2760

actgcaagca ggccgtctac ttcttcagcc ctgccccaga tcccagagca ctgctgggtg     2820

gcccacggac tgtcagctat gcagtggagt ttcaccccga cacaggcgac atcatcatgg     2880

agttcaggca tgcagatacc ccagactgac cactcttgag caataaagtg gcctgagggc     2940

tggggttctg a                                                          2951


<210> 1178
<211> 1450
<212> DNA
<213> Homo sapiens

<400> 1178
ttccggtagc ggcggcggga aatcggctgt gggagagagg ctaggcctct gaggaggcga       60

atccggcggg tatcagagcc atcagaaccg ccaccatgac ggtgggcaag agcagcaaga      120

tgctgcagca tattgattac aggatgaggt gcatcctgca ggacggccgg atcttcattg      180

gcaccttcaa ggcttttgac aagcacatga atttgatcct ctgtgactgt gatgagttca      240

gaaagatcaa gtgtgtgagg ggggagagct tgagtttctg gcctcattgc ctatttgtaa      300

agctgtagcc taaagggctc tcccaatgca gcctggtctg aaactgcttt aagaagcctc      360

tgaccctctt cagggccaaa gaactccaaa caagcagaaa gggaagagaa gcgagtcctc      420

ggtctggtgc tgctgcgagg ggagaatctg gtctcaatga cagtagaggg acctcctccc      480

aaagatactg gtattgctcg agttccactt gctggagctg ccgggggccc agggatcggc      540

agggctgctg gcagaggaat cccagctggg gttcccatgc cccaggctcc tgcaggactt      600

gctgggccag tccgtggggt tggcgggcca tcccaacagg tgatgacccc acaaggaaga      660

ggtactgttg cagccgctgc agctgctgcc acagccagta ttgccggggc tccaacccag      720

tacccacctg gccgtggggg tcctccccca cctatgggcc gaggagcacc ccctccaggc      780

atgatgggcc cacctcctgg tatgagacct cctatgggtc ccccaatggg gatcccccct      840

ggaagaggga ctccaatggg catgccccct ccgggaatgc ggcctcctcc ccctgggatg      900

cgaggtaagt gcctgcagtg gtgactttgg cttctttccc tagagcctag tgggatagga      960

aatggaggga agattgcatt tagatcatat cccatgggct ttcaagcctt aaatctaggg     1020

aaatccagaa aggaaagaga agagggaaca tttcttaaat tgggcttacc tcccctctta     1080

gaaaagttag agcagccatg cacccagggt gtttctcaat atctaaggca gcggcctcag     1140

gacacaatga aataatgcat tctgaggatc cctaacagaa gttatgagat tgtcttatgc     1200

tctttggttt gacagtgcct agtaattaag agggggctct gggctttgct gtactattat     1260

ggatttctct ttaacttcag ttggagaaat tctgagatca gtccccacat ggatgagaaa     1320

ataggccccc agggagtttg gactccaagc ccagtgttct ttccctataa gataacccat     1380

gggcaaactt ggtgacccct gtttctctag tctggattat tcctctatgg gtttttatag     1440

acataggaac                                                            1450


<210> 1179
<211> 506
<212> DNA
<213> Homo sapiens

<400> 1179
cggaggcagg ttggagccgc tgccgtcgcc atgacccgcg gtaaccagcg tgagctcgcc       60

cgccagaaga atatgaaaaa gcagagcgac tcggttaagg gaaagcgccg agatgacggg      120

ctttctgctg ccgcccgcaa gcagagtgcc ccatcatctc tacccccagg gactcggaga      180

tcatgcagca gaagcagaaa aaggcaaacg agaagaagga ggaacccaag tagctttgtg      240

gcttcgtgtc caaccctctt gcccttcgcc tgtgtgcctg gagccagtcc caccacgctc      300

gcgtttcctc ctgtagtgct cacaggtccc agcaccgatg gcattccctt tgccctgagt      360

ctgcagcggg tcccttttgt gcttccttcc cctcaggtag cctctctccc cctgggccac      420

tcccgggggt gagggggtta ccccttccca gtgtttttta ttcctgtggg gctcacccca      480

aagtattaaa agtagctttg taattc                                           506


<210> 1180
<211> 2470
<212> DNA
<213> Homo sapiens

<400> 1180
gtccactggg cttggagtca gtggcaataa ccaggggcaa taaccaggcg tgtcccaggg       60

gggagccccg ctctgcagcc ctgtgcgccg tagagagctg gacttaggct ggcagcatgg      120

ccgagttcag ggtcagggtg tccaccggag aagccttcgg ggctggcaca tgggacaaag      180

tgtctgtcag catcgtgggg acccggggag agagcccccc actgcccctg gacaatctcg      240

gcaaggagtt cactgcgggc gctgaggagg acttccaggt gacgctcccg gaggacgtag      300

gccgagtgct gctgctgcgc gtgcacaagg cgcccccagt gctgcccctg ctggggcccc      360

tggccccgga tgcctggttc tgccgctggt tccagctgac accgccgcgg ggcggccacc      420

tcctcttccc ctgctaccag tggctggagg gggcggggac cctggtgctg caggagggta      480

cagccaaggt gtcctgggca gaccaccacc ctgtgctcca gcaacagcgc caggaggagc      540

ttcaggcccg gcaggagatg taccagtgga aggcttacaa cccaggttgg cctcactgcc      600

tggatgaaaa gacagtggaa gacttggagc tcaatatcaa atactccaca gccaagaatg      660

ccaactttta tctacaggct ggctctgctt ttgcagagat gaaaatcaag gggttgctgg      720

accgcaaggg gctctggagg agtctgaatg agatgaaaag gatcttcaac ttccggagga      780

ccccagcagc tgagcacgca tttgagcact ggcaggagga cgccttcttc gcctcccagt      840

tcctgaatgg tctcaaccct gtcctgatcc gccgctgtca ctacctccca aagaacttcc      900

ccgtcactga tgccatggtg gcctcagtgt tgggtcctgg gaccagcttg caggctgagc      960

tagagaaggg ctccctgttc ttggtggatc acggcatcct ctctggcatc cagaccaatg     1020

tcattaatgg gaagcctcag ttctctgcgg ccccaatgac cctgctatac cagagcccag     1080

gctgcgggcc gctgctgcct ctcgccatcc agctcagcca gacccccggc ccaaacagcc     1140

ccatcttcct gcccactgat gacaagtggg actggttgct ggccaagacc tgggtgcgca     1200

atgccgagtt ctccttccat gaggccctca cgcacctgct gcactcacat ctgctgcctg     1260

aggtcttcac cctggctacc ctgcgtcagc tgccccactg ccaccctctc ttcaagtcca     1320

caggcatcgg cattgaaggc ttctctgagt tgatacagag gaacatgaag cagctgaact     1380

attctctcct gtgtctgcct gaggatatcc ggacccgagg agttgaagac atcccaggct     1440

actactaccg tgatgatggg atgcagatct ggggtatacc ctcctcactg gagacccggg     1500

aagccctggt gcagtatgtc accatggtga tattcacctg ctccgccaag catgcggctg     1560

tcagtgcagg gcagtttgac tcctgtgctt ggatgcccaa cctgccaccc agcatgcagc     1620

tgccaccacc cacctccaaa ggcctggcaa catgcgaggg cttcatagcc accctcccac     1680

ctgtcaatgc cacatgtgat gtcatccttg ctctctggtt gctgagcaag gagcctggag     1740

accaaaggcc cctgggcacc tatccggatg agcacttcac agaggaggcc cctcggcgga     1800

gcatcgccac cttccagagc cgcctggccc agatctcgag gggcatccag gagcggaacc     1860

agggcctggt gctgccctac acctacctag accctcccct catcgagaac agcgtctcca     1920

tctaaatccc aggggaacac aggcccagat gacatccctt tgaccacatc gctctaggat     1980

aactggcacc cagagaaaag gactcctcag aaaaaacagg cccccatgtg cctctcctgg     2040

gacaaccaga ctctgtaact cacccccacc accatacaca cacacaaaaa cagaaacaaa     2100

atcaaaacag agaaagcaga aaatctacca agaacagagt ctcaggacag aaccactgag     2160

tcttttggag gctccaagcc tcaaagtgcc cgcagagccc accttgaggg ttttgctagt     2220

tggttttgtt ttgcgtttta cagccgtggg gggaagcaca taatcccgcc ccagggccca     2280

ctagcatcca ctgattggac cttatggtca cccaactcaa ggacagccac caagaagtgg     2340

ctgccaaaga gactgggcgc agtggctcat gcccataatc ccagcacttt gggagatgga     2400

ggcgggaaaa tcatttgagg tcagaagttc aaggccagcc tggacgacat agcgagactc     2460

cacctctacc                                                            2470


<210> 1181
<211> 3422
<212> DNA
<213> Homo sapiens

<400> 1181
cagccctcat ctccgccggc gagtagggcc aggtgttggg agctcccacg tgggacaaga       60

tggtgtcttc ggcgcagatg ggcttcaacc tgcaggctct cctggagcag ctcagccagg      120

atgagttgag caagttcaag tatctgatca cgaccttctc cctggcacac gagctccaga      180

agatccccca caaggaggta gacaaggctg atgggaagca actggtagaa atcctcacca      240

cccattgtga cagctactgg gtggagatgg cgagcctcca ggtctttgaa aagatgcacc      300

gaatggatct gtctgagaga gcaaaggatg aagtcagaga agcagctttg aaatccttta      360

ataaaaggaa gcctctatca ttagggataa cacggaaaga acgaccacct ctagacgtgg      420

acgaaatgct ggagcgcttc aaaacagaag cacaagacaa agacaatagg tgcaggtata      480

tattgaagac gaagttccgg gagatgtgga agagctggcc tggagatagc aaagaggtcc      540

aggttatggc tgagagatac aagatgctga tcccattcag caaccccagg gtgcttcccg      600

ggcccttctc atacacggtg gtgctgtatg gtcctgcagg ccttgggaaa accacgctgg      660

cccagaaact aatgctagac tgggcagagg acaacctcat ccacaaattc aaatatgcgt      720

tctacctcag ctgcagggag ctcagccgcc tgggcccgtg cagttttgca gagctggtct      780

tcagggactg gcctgaattg caggatgaca ttccacacat cctagcccaa gcacggaaaa      840

tcttgttcgt gattgacggc tttgatgagc tgggagccgc acctggggcg ctgatcgagg      900

acatctgcgg ggactgggag aagaagaagc cggtgcccgt cctcctgggg agtttgctga      960

acagggtgat gttacccaag gccgccctgc tggtcaccac gcggcccagg gccctgaggg     1020

acctccggat cctggcggag gagccgatct acataagggt ggagggcttc ctggaggagg     1080

acaggagggc ctatttcctg agacactttg gagacgagga ccaagccatg cgtgcctttg     1140

agctaatgag gagcaacgcg gccctgttcc agctgggctc ggcccccgcg gtgtgctgga     1200

tcgtgtgcac gactctgaag ctgcagatgg agaaggggga ggacccggtc cccacctgcc     1260

tcacccgcac ggggctgttc ctgcgtttcc tctgcagccg gttcccgcag ggcgcacagc     1320

tgcggggcgc gctgcggacg ctgagcctcc tggccgcgca gggcctgtgg gcgcagacgt     1380

ccgtgcttca ccgagaggat ctggaaaggc tcggggtgca ggagtccgac ctccgtctgt     1440

tcctggacgg agacatcctc cgccaggaca gagtctccaa aggctgctac tccttcatcc     1500

acctcagctt ccagcagttt ctcactgccc tgttctacac cctggagaag gaggaggaag     1560

aggataggga cggccacacc tgggacattg gggacgtaca gaagctgctt tccggagtag     1620

aaagactcag gaaccccgac ctgatccaag caggctacta ctcctttggc ctcgctaacg     1680

agaagagagc caaggagttg gaggccactt ttggctgccg gatgtcaccg gacatcaaac     1740

aggaattgct gcgatgcgac ataagttgta agggtggaca ttcaacggtg acagacctgc     1800

aggagctcct cggctgtctg tacgagtctc aggaggagga gctggtgaag gaggtgatgg     1860

ctcagttcaa agaaatatcc ctgcacttaa atgcagtaga cgttgtgcca tcttcattct     1920

gcgtcaagca ctgtcgaaac ctgcagaaaa tgtcactgca ggtaataaag gagaatctcc     1980

cggagaatgt cactgcgtct gaatcagacg ccgaggttga gagatcccag gatgatcagc     2040

acatgcttcc tttctggacg gacctttgtt ccatatttgg atcaaataag gatctgatgg     2100

gtctagcaat caatgatagc tttctcagtg cctccctagt aaggatcctg tgtgaacaaa     2160

tagcctctga cacctgtcat ctccagagag tggtgttcaa aaacatttcc ccagctgatg     2220

ctcatcggaa cctctgccta gctcttcgag gtcacaagac tgtaacgtat ctgacccttc     2280

aaggcaatga ccaggatgat atgtttcccg cattgtgtga ggtcttgaga catccagaat     2340

gtaacctgcg atatctcggg ttggtgtctt gttccgctac cactcagcag tgggctgatc     2400

tctccttggc ccttgaagtc aaccagtccc tgacgtgcgt aaacctctcc gacaatgagc     2460

ttctggatga gggtgctaag ttgctgtaca caactttgag acaccccaag tgctttctgc     2520

agaggttgtc gttggaaaac tgtcacctta cagaagccaa ttgcaaggac cttgctgctg     2580

tgttggttgt cagccgggag ctgacacacc tgtgcttggc caagaacccc attgggaata     2640

caggggtgaa gtttctgtgt gagggcttga ggtaccccga gtgtaaactg cagaccttgg     2700

tgctttggaa ctgcgacata actagcgatg gctgctgcga tctcacaaag cttctccaag     2760

aaaaatcaag cctgttgtgt ttggatctgg ggctgaatca cataggagtt aagggaatga     2820

agttcctgtg tgaggctttg aggaaaccac tgtgcaactt gagatgtctg tggttgtggg     2880

gatgttccat ccctccgttc agttgtgaag acctctgctc tgccctcagc tgcaaccaga     2940

gcctcgtcac tctggacctg ggtcagaatc ccttggggtc tagtggagtg aagatgctgt     3000

ttgaaacctt gacatgttcc agtggcaccc tccggacact caggttgaaa atcgatgact     3060

ttaatgatga actcaataag ctgctggaag aaatagaaga aaaaaaccca caactgatta     3120

ttgatactga gaaacatcat ccctgggcag aaaggccttc ttctcatgac ttcatgatct     3180

gaatcccccc gagtcattca ttctccatga agtcatcgat tttccaggtg ttggtgaact     3240

gcctgtgact cctctcctcc ccggccccta cccctcaggg ataatgagtt cattgctggg     3300

ctagatgttt tagccatgat tctgcctctg ttttatacct gcacacatcc ttatctttgt     3360

tacatatgaa atatctgtat cacgggtata ttgagagaaa taaaggtgag agcattcaca     3420

aa                                                                    3422


<210> 1182
<211> 7775
<212> DNA
<213> Homo sapiens

<400> 1182
agaggggaaa agaacgtcag gagagtgaac gggagcaaat aaaacgctgt ccattctgac       60

tggaagggcc agagccgtgt ctaagggcgg gggccgggag gtggcccgcg gtggtgtctc      120

taccaggacg aggcctgggg tatctgaaga ggggatgacg tccaggcgct ttgctaaagg      180

gaagccagaa gggtatgagt tgctagggtc agagatgggg ctttcggctc gagtctttcc      240

ctgcagggca gagagtccga agagcccgag aaggcaggga ggacagtggg cctggtcctt      300

ccccggccgg cagagggagt cccgagatgg aacgtccagc tctcctctaa cgaaaagcgt      360

ttgcatggct gtctcgccaa ttctgtacct cccggggctg aggaagagcc gaggtgacta      420

gaagctagcg acaagtgccg gccacctccg acgccaggcg ccgggcttgg agcccgacgg      480

gccgaattct cgcgagagcg gccgccgcca tttttccatt gattgcagcg ggctggggga      540

ggggccgacg acgaaggcgg ctgtggtagc ggcggcggcg gcggcggagc cctgggtcgg      600

tgtctgcgcg ctggtgtctg aggcccaggc tgaggcctcc gctattgctg gagcgcaggc      660

ggcggagagg atgactgccg ctgccattct ctcttgagct agcgagccgc cgccaccctc      720

caccctcccc cggcagggcg gagaggagcg gccggagtca gcgatggtgc ccggcgagga      780

gaaccaactg gtcccgaaag aggcaccact ggatcatacc agtgacaagt cacttctcga      840

cgctaatttt gagccaggaa agaagaactt tctgcatttg acagataaag atggtgaaca      900

acctcaaata ctgctggagg attccagtgc tggggaagac agtgttcatg acaggtttat      960

aggtccgctt ccaagagaag gttctggggg ttctaccagt gattatgtca gccaaagcta     1020

ctcctactca tctattttga ataaatcaga aactggatat gtgggactag taaaccaagc     1080

aatgacttgc tatttgaata gccttttgca aacacttttt atgactcctg aatttaggaa     1140

tgcattatat aagtgggaat ttgaagaatc tgaagaagat ccagtgacaa gtattccata     1200

ccaacttcaa aggctttttg ttttgttaca aaccagcaaa aagagagcaa ttgaaaccac     1260

agatgttaca aggagctttg gatgggatag tagtgaggct tggcagcagc atgatgtaca     1320

agaactatgc agagtcatgt ttgatgcttt ggaacagaaa tggaagcaaa cagaacaggc     1380

tgatcttata aatgagctat atcaaggcaa gctgaaggac tacgtgagat gtctggaatg     1440

tggttatgag ggctggcgaa tcgacacata tcttgatatt ccattggtca tccgacctta     1500

tgggtccagc caagcatttg ctagtgtgga agaagcattg catgcattta ttcagccaga     1560

gattctggat ggcccaaatc agtatttttg tgaacgttgt aagaagaagt gtgatgcacg     1620

gaagggcctt cggtttttgc attttcctta tctgctgacc ttacagctga aaagattcga     1680

ttttgattat acaaccatgc ataggattaa actgaatgat cgaatgacat ttcccgagga     1740

actagatatg agtactttta ttgatgttga agatgagaaa tctcctcaga ctgaaagttg     1800

cactgacagt ggagcagaaa atgaaggtag ttgtcacagt gatcagatga gcaacgattt     1860

ctccaatgat gatggtgttg atgaaggaat ctgtcttgaa accaatagtg gaactgaaaa     1920

gatctcaaaa tctggacttg aaaagaattc cttgatctat gaacttttct ctgttatggt     1980

tcattctggg agcgctgctg gtggtcatta ttatgcatgt ataaagtcat tcagtgatga     2040

gcagtggtac agcttcaatg atcaacatgt cagcaggata acacaagagg acattaagaa     2100

aacacatggt ggatcttcag gaagcagagg atattattct agtgctttcg caagttccac     2160

aaatgcatat atgctgatct atagactgaa ggatccagcc agaaatgcaa aatttctaga     2220

agtggatgaa tacccagaac atattaaaaa cttggtgcag aaagagagag agttggaaga     2280

acaagaaaag agacaacgag aaattgagcg caatacatgc aagataaaat tattctgttt     2340

gcatcctaca aaacaagtaa tgatggaaaa taaattggag gttcataagg ataagacatt     2400

aaaggaagca gtagaaatgg cttataagat gatggattta gaagaggtaa tacccctgga     2460

ttgctgtcgc cttgttaaat atgatgagtt tcatgattat ctagaacggt catatgaagg     2520

agaagaagat acaccaatgg ggcttctact aggtggcgtc aagtcaacat atatgtttga     2580

tctgctgttg gagacgagaa agcctgatca ggttttccaa tcttataaac ctggagaagt     2640

gatggtgaaa gttcatgttg ttgatctaaa ggcagaatct gtagctgctc ctataactgt     2700

tcgtgcttac ttaaatcaga cagttacaga attcaaacaa ctgatttcaa aggccatcca     2760

tttacctgct gaaacaatga gaatagtgct ggaacgctgc tacaatgatt tgcgtcttct     2820

cagtgtctcc agtaaaaccc tgaaagctga aggatttttt agaagtaaca aggtgtttgt     2880

tgaaagctcc gagactttgg attaccagat ggcctttgca gactctcatt tatggaaact     2940

cctggatcgg catgcaaata caatcagatt atttgttttg ctacctgaac aatccccagt     3000

atcttattcc aaaaggacag cataccagaa agctggaggc gattctggta atgtggatga     3060

tgactgtgaa agagtcaaag gacctgtagg aagcctaaag tctgtggaag ctattctaga     3120

agaaagcact gaaaaactca aaagcttgtc actgcagcaa cagcaggatg gagataatgg     3180

ggacagcagc aaaagtactg agacaagtga ctttgaaaac atcgaatcac ctctcaatga     3240

gagggactct tcagcatcag tggataatag agaacttgaa cagcatattc agacttctga     3300

tccagaaaat tttcagtctg aagaacgatc agactcagat gtgaataatg acaggagtac     3360

aagttcagtg gacagtgata ttcttagctc cagtcatagc agtgatactt tgtgcaatgc     3420

agacaatgct cagatccctt tggctaatgg acttgactct cacagtatca caagtagtag     3480

aagaacgaaa gcaaatgaag ggaaaaaaga aacatgggat acagcagaag aagactctgg     3540

aactgatagt gaatatgatg agagtggcaa gagtagggga gaaatgcagt acatgtattt     3600

caaagctgaa ccttatgctg cagatgaagg ttctggggaa ggacataaat ggttgatggt     3660

gcatgttgat aaaagaatta ctctggcagc tttcaaacaa catttagagc cctttgttgg     3720

agttttgtcc tctcacttca aggtctttcg agtgtatgcc agcaatcaag agtttgagag     3780

cgtccggctg aatgagacac tttcatcatt ttctgatgac aataagatta caattagact     3840

ggggagagca cttaaaaaag gagaatacag agttaaagta taccagcttt tggtcaatga     3900

acaagagcca tgcaagtttc tgctagatgc tgtgtttgct aaaggaatga ctgtacggca     3960

atcaaaagag gaattaattc ctcagctcag ggagcaatgt ggtttagagc tcagtattga     4020

caggtttcgt ctaaggaaaa aaacatggaa gaatcctggc actgtctttt tggattatca     4080

tatttatgaa gaagatatta atatttccag caactgggag gttttccttg aagttcttga     4140

tggggtagag aagatgaagt ccatgtcaca gcttgcagtt ttgtcaagac ggtggaagcc     4200

ttcagagatg aagttggatc ccttccagga ggttgtattg gaaagcagta gtgtggacga     4260

attgcgagag aagcttagtg aaatcagtgg gattcctttg gatgatattg aatttgctaa     4320

gggtagagga acatttccct gtgatatttc tgtccttgat attcatcagg atttagactg     4380

gaatcctaaa gtttctaccc tgaatgtctg gcctctttat atctgtgatg atggtgcggt     4440

catattttat agggataaaa cagaagaatt aatggaattg acagatgagc aaagaaatga     4500

actgatgaaa aaagaaagca gtcgactcca gaagactgga catcgtgtaa catactcacc     4560

tcgtaaagag aaagcactaa aaatatatct ggatggagca ccaaataaag atctgactca     4620

agactgactc tgatagtgta gcattttccc tgggggagtt ttggttttaa ttagatggtt     4680

cactaccact gggtagtgcc attttggccg gacatggttg gggtaaccca gtgacaccag     4740

cactgattgg actgccctac accaatcaga agctcagtgc ccaatgggcc actgttttga     4800

ctcggaatca tgttgtgcac tatagtcaaa tgtactgtaa agtgaaaagg gatgtgcaaa     4860

aaaataaaaa aaaacaacaa aaaaagctaa ccttctatta gaaaagggga caggggaatg     4920

agtaaacttc ttttattgcg gacaaatgtg cacatagccg ctagtaaaac tagcctcaaa     4980

caggatgctc atagcttaat aataaaagct gtgcaaaggc catgaatgaa tgaattttct     5040

gtttatttca ctgatgcaca cattacctca ttgacaattc agaagtaaat ccaacgtgtg     5100

ttgactcttg gaaagcagca aaaacaggag ctgaagaaaa gaaattcttg gaaccagccg     5160

taacccagta aggaattgtg aagttgtgtt tttattttgt ttcatttttt gcagagtatt     5220

aagaacatta ttctggaaca tcagaacgtt tcccttagac cgatcccagc aggtggcagc     5280

tcagattgct gcagtgttgt aattataact gattgtactt aagttatgga tgtagagaat     5340

atgtttcatt catttattca gcatgtaaat aaaattgatc ctgttgagtt atcataattg     5400

cagttcaact atctgccatg attattcttt tcacgtatca ttcattctgt acatttgtgt     5460

acattgagaa gtatagcaat ctatgtaaat gtaatcctca gtgaggttcc tcagtgctag     5520

gtcccatagg attgtcgttg cccttgttaa tgaggtttct ctgttcagcg gcttcaattt     5580

ttttctcttt gtacatctag ttttgaagat ttacttcaag tttgaatctt ctagaatgct     5640

tgtaagtcca gttttaattt ttagagtcaa tttgtagtta catgtagttt aacttttggg     5700

aaacgtctta acattgttct gaataaactt gctaatgagg tcaggtcatg gtacagactg     5760

atgcagtcaa catgatttca ttgcagagtt tattagtatc agcaagtttt tgctttgcta     5820

aataaaagta ctcaatgaac acaattctac ataaattttg acataccatc taatttataa     5880

aaatcaataa aaaaggtttt ggtaaaactt tttcatgcca gatgctgttt acaacaatga     5940

acatgccaat aaaacatttg ttcattctgt tgtgttattt tagtcattaa acttctgtgg     6000

atgaagaatc tgggttaaga atagatttgt catctttaaa tatgacattt tgtaatgtgt     6060

attggatatc tcatttctat gataaaggta tatttacagt aaagttctca taagagaaat     6120

gaaaagctgt gttaatatct aactttgggg aaccctgtca gtatttcaga tccgattttt     6180

accctttttt tcttataaga aagataaaat tagaaaatac tgttagcaaa tgtggctctg     6240

ccatttgaat ataatcaccg agaattccat gtcttaaaag tctcctggaa tccacaatga     6300

aaaaaaaaat cttttctaag gtatttttct ggctaatttt tatttgaaga aagctatagc     6360

atttagcgaa atttgactga agtaatgttc tgagtttgca ttagtgggat tggtgatgtt     6420

ctcagaagaa aattggaaac acttgtgatg aattgtcttt cagatcactt agattttctg     6480

atgtaagagg acagctgttt ggttctgata caggcctgct tacttgggat gtagggttag     6540

taaatggggt ttctgcttta aaggactgac ttgctatcac acaaaagagg cagacttgta     6600

aacacaatgg gctttggagt ttggtctgat tgggtttggt ttagtattcc tatgagcgta     6660

aatggtaaaa ttcttctgat acccactctt tagactgtgc cttctgctct gttctttgtt     6720

ttatgtttaa ctgctgtttc taattgcagg tgtattacag atacaaataa gagtaaagaa     6780

aatatatttc attatagaaa agaaaaaatt aaaagcttct tgcttttcag tgcctgatag     6840

agtgaaaaca caaagttgca ctttaataat ttcaataaaa gctaatctgt gtcagcctcc     6900

ctctgcttca gagagtcagg tgagcatcca taacctaaca ggcagagccc tagcgatgtg     6960

gatcaagttt cctgagcccg ggggcggtgg agcctcatga tctcttatct tttgaggctg     7020

aggcaggtca catgcaacaa attgtgaccc tgctccccac aagtcatgca aaggttttga     7080

agagctttta ccgtggggca gatgaacttg tgtcaaccat gcacaccctg tgagaaccaa     7140

gtacctgtgt ttctaaggcg ggcactcaag gtgaggggtg cattctggcc aaagaaacaa     7200

aagctgtggt ttcaggacca tgccgtgtgt agctgatctg tacgggacgt gtatgtaagg     7260

aagagcaatc atgatagata agaacagtgt gtgaagcagc cttcacacta gagtgtttgg     7320

tcatctctta taatgtaagg gaaggtactt taaaattctg ggaagatgcg atgaactcat     7380

gtcccagtca gaaaataatc caatgaaata agcattggtt gccaggccac agttaggaat     7440

tgtattgtga tacatctaga ggccaagaga gcaggagaga gctaccaact tacactgtgg     7500

tttaagctaa atgaccgcac agcatcatag cattgcagtg ttgttactaa atctggaagt     7560

gacctgtgaa tgtatggaat acaataaagt cttttattct ggttcatttg ctagtacttc     7620

ctttttgatt ggatactgta gttcttcctc tggattttat tttgttcagc gtcaaggccc     7680

taattttgca aatgtagtct aaaccacatt acgtggacta gaggatactc tgaattagca     7740

agttttttgt ttgctgaata aaactattcc atctt                                7775


<210> 1183
<211> 1014
<212> DNA
<213> Homo sapiens

<400> 1183
gttttcacca tgttggccag gctggtctgg aaccccgact tcaggtgatc cacgttggcc       60

tcccaaagtg ttgggattac aggtgtgaac cactgcgcct ggccatgaag tgtccaataa      120

atattagatt gacataaaga accctcaggt gtgctatctc atggaatacc ctcaaattcc      180

tctctggatc ttcctatcac agttgtatta ttggggtccc atttggatct ctcccactat      240

aggtagctct tcagtgggac gggctaggta agagaggctg ggagtaagtc tgtctgatct      300

aggatgtctt gcttaccacc caggtagggg gttatatact cccagccttt ctgattccat      360

tgtaactctt gccgaaatcc gggtgaacgg aagtagtctc tttaagaact ggtatgggca      420

ggcccaagtt gtcaaggctt cggaggtaat gccctggaga gcggggaacg gggtgggttt      480

agaggcccag gcgggcaccc aggaggcagg cccagaagag tactgccagg aagagttggg      540

cgccgaggag gagatggcag ccagagcagc atggcctgtg ctgcgctctg tgaactcacg      600

cgagctctcc cggatcatca tctgcaatca cagcccacga atcgtgctgc ctgtgtggct      660

caactactat ggcaagctgc tgccctacct gacgctgctg cccggcaggg acttccgcat      720

ccacaacttc cgaagccacc cttggctctt cagagatgca aggacacatg ataagcttct      780

ggttaaccaa actgaattgt ttgtgccatc ttccaatgtt aatggacagc ctgtttttgc      840

caacatcaca ctgcagtgta taccctgaaa gagcaatgcc tccaggttgt cggaagccta      900

gtcaagccca agaattacag gagactggac atcgtcagat cactctatga cgatctggaa      960

gatcatccaa atgtgattga aagacctgga gcggctgacg caggagcaca gtga           1014


<210> 1184
<211> 713
<212> DNA
<213> Homo sapiens

<400> 1184
atggaggggt gtgtgtctaa cctaatggtc tgcaacctgg cctacagcgg gaagctggaa       60

gagttgaagg agagtattct ggccgataaa tccctggcta ctagaactga ccaggcaggt      120

tggtctcctc ttcatattgc ggcttctgct ggccgggatg agattgtaaa agcccttctg      180

ggaaaaggtg ctcaagtgaa tgctgtcaat caaaatggct gtactccctt acattatgca      240

gcttcgaaaa acaggcatga gatcgctgtc atgttactgg aaggcggggc taatccagat      300

gctaaggacc attatgaggc tacagcaatg caccgggcag cagccaaggg taacttgaag      360

atgattcata tccttctgta ctacaaagca tccacaaaca tccaagacac tgagggtaac      420

actcctctac acttagcctg tgatgaggag agagtggaag aagcaaaact gctggtgtcc      480

caaggagcaa gtatttacat tgagaataaa gaagaaaaga cacccctgca agtggccaaa      540

ggtggcctgg gtttaatact caagagaatg gtggaaggtt aaacagcttg gatttattct      600

tactttgtat gttgtgttgt tgtccccagt gtcctacaaa ctaatgtatt tgtgcacaag      660

acatcatcta tgaatgatga agttttctca ccttcaaagt cttataaaca tgt             713


<210> 1185
<211> 1259
<212> DNA
<213> Homo sapiens

<400> 1185
ggacagcttg gagatagggc ccggaattgc gggcgtcact ctgctcctgc gacctagcca       60

ggcgtgaggg agtgacagca gcgcattcgc gggacgagag cgatgagtga gaacgccgca      120

ccaggtctga tctcagagct gaagctggct gtgccctggg gccacatcgc agccaaagcc      180

tggggctccc tgcagggccc tccagttctc tgcctgcacg gctggctgga caatgccagc      240

tccttcgaca gactcatccc tcttctcccg caagactttt attacgttgc catggatttc      300

ggaggtcatg ggctctcgtc ccattacagc ccaggtgtcc catattacct ccagactttt      360

gtgagtgaga tccgaagagt tgtggcagcc ttgaaatgga atcgattctc cattctgggc      420

cacagcttcg gtggcgtcgt gggcggaatg tttttctgta ccttccccga gatggtggat      480

aaacttatct tgctggacac gccgctcttt ctcctggaat cagatgaaat ggagaacttg      540

ctgacctaca agcggagagc catagagcac gtgctgcagg tagaggcctc ccaggagccc      600

tcgcacgtgt tcagcctgaa gcagctgctg cagaggcaga gaacagcatt gacttcatca      660

gcagggagct gtgtgcgcat tccatcagga agctgcaggc ccatgtcctg ttgatcaaag      720

cagtccacgg atattttgat tcaagacaga attactctga gaaggagtcc ctgtcgttca      780

tgatagacac gatgaaatcc accctcaaag agcagttcca gtttgtggaa gtcccaggca      840

atcactgtgt ccacatgagc gaaccccagc acgtggccag tatcatcagc tccttcttac      900

agtgcacaca catgctccca gcccagctgt agctctgggc ctggaactat gaagacctag      960

tgctcccaga ctcaacactg ggactctgag ttcctgagcc ccacaacaag gccagggatg     1020

gtggggacag gcctcactag tcttgaggcc cagcctagga tggtagtcag gggaaggagc     1080

gagattccaa cttcaacatc tgtgacctca agggggagac agagtctggg ttccagggct     1140

gctttctcct ggctaataat aaatatccag ccagctggag gaaggaaggg caggctgggc     1200

ccacctagcc tttccctgct gcccaactgg atggaaaata aaaggttctt gtattctca      1259


<210> 1186
<211> 1648
<212> DNA
<213> Homo sapiens

<400> 1186
gacacactgc acagcgacca ctgagcatgc ctgcaggctc catgtctact acaggctatc       60

ctggtgtctg cagtaccaca tcatacagaa ctcactgtta tatcccagtg acctcttctg      120

ttactcttag ctccagtgat ttaagcccta cctttggaca ctgcttaccc agtagctacc      180

aaggaaatct ctggctcctg gattactgcc aagaatccta cggtgaagca ccaacctgca      240

aatctcccag ctgtgagccc aagacctgca gtaccactgg ttgtgacccg tcaaactcct      300

ctgtgccctg caactcccca tcagcaggcc aagtcttcag tgtctgtgaa actaccaacg      360

tcagccccag ccccagctgc agcccaagca cccagaccaa tgggtatgta tgcaattgcc      420

acatacccac tcgaaatgca tccaaagcct gccaaaccct ccgcaacggt tccaactgct      480

ttggacaact taactgctta tccaagagtt tccaaactct aaaccactgc agattgagta      540

ctttggggta taaaagctac caaaatcctt gcttcatacc cagctacgtc tcaccattat      600

gttatatttc caacagctgc caaccccaaa gctatttagt gagaaattat cactattcaa      660

gctacaggcc tacgagctgc cgaccactga gctatttatc tagaagcttc agatctctga      720

gctatatacc cagtaccttt ccacctctga ggtatttgtg cagtggtagc agacctctga      780

aatgctattg accaacttcc agaatttata gcagctggaa attgcccaat ggggaagatt      840

ctactaagta ctagaacgtc taattttctg ctgaatctct ttattcagcc taagaatctt      900

gttacattaa gttcaaatac aactcccagg tttattaacc acagccagta tcacctgcta      960

ggttttcttt tttctgttgt tctgttattg ctctttgtac taaaagctga ccctgaaggt     1020

aacatcatta tttctgagat ttattacaat ggacttaccg aagagactcc atttgaaata     1080

caaccatcac cggctttctt actttggctg tcactgtcac ttgtctgaca gtgtgattat     1140

cacctacctt tcctgatgaa atggggcctc catggtttga ctgcagattc cagcatgcaa     1200

attcattcgg atggctttga ttgtcattaa tatttttgtc aactacctaa ctagcacctt     1260

gctaataagc cgatagaaaa cactatcttg agcataataa gttgaactat ttcatccttt     1320

tcttactgat tgattgtaag aacaggcaaa tagcaatggt gactagagct caaaaataga     1380

agacttcagc aaatcttctc ttccagagaa gccataaaac aagattcact ggtactcagc     1440

ttttgttctc catgcctaag aaaaagcctc agaattagct aaagcatgaa aattatttgt     1500

tgaaagaaga acaaatactg ttagagaccc tttacaatta tgtgtaatct gcgtttagga     1560

ttctcctatc atcttgcctt gccaatttat tgcattctga ctctggaaaa tgtcctagtt     1620

cttagttaat aaacaaattt ctgtctgg                                        1648


<210> 1187
<211> 1637
<212> DNA
<213> Homo sapiens

<400> 1187
gttctggcag cccattccga gactagcgga ggcgggcagg gagggtatat aagcgttggc       60

ggagcgtcgg ttgtagcact ctgcgcgccc gctcttctgc tgctgtttgt ctacttcctc      120

ctgcttcccc gccgccgccg ccgccatcat gagggaaatc gtgcacttgc aggccgggca      180

gtgcggcaac caaatcggcg ccaagttttg ggaggtgatc agcgatgagc acggcatcga      240

ccccacgggc acctaccacg gggacagcga cctgcagctg gaacgcatca acgtgtacta      300

caatgaggcc accggcggca agtacgtgcc ccgcgccgtg ctcgtggatc tggagcccgg      360

caccatggac tccgtgcgct cggggccctt cgggcagatc ttccggccgg acaacttcgt      420

tttcggtcag agtggtgctg ggaacaactg ggccaagggg cactacacag aaggcgcgga      480

gctggtggac tcggtgctgg atgttgtgag aaaggaggct gagagctgtg actgcctgca      540

gggtttccag ctgacccact ccctgggtgg ggggactggg tctgggatgg gtaccctcct      600

catcagcaag atccgggagg agtacccaga caggatcatg aacacgttta gtgtggtgcc      660

ttcgcccaaa gtgtcagaca cagtggtgga gccctacaac gccaccctct cagtccacca      720

gctcgtagaa aacacagacg agacctactg cattgataac gaagctctct acgacatttg      780

cttcagaacc ctaaagctga ccacgcccac ctatggtgac ctgaaccacc tggtgtctgc      840

taccatgagt ggggtcacca cctgcctgcg cttcccaggc cagctcaatg ctgacctgcg      900

gaagctggct gtgaacatgg tcccgtttcc ccggctgcac ttcttcatgc ccggctttgc      960

cccactgacc agccggggca gccagcagta ccgggcgctg accgtgcccg agctcaccca     1020

gcagatgttt gatgccaaga acatgatggc tgcctgcgac ccccgccatg gccgctacct     1080

gacggttgcc gccgtgttca ggggccgcat gtccatgaag gaggtggatg agcaaatgct     1140

taatgtccaa aacaaaaaca gcagctattt tgttgagtgg atccccaaca atgtgaaaac     1200

ggctgtctgt gacatcccac ctcgggggct aaaaatgtcc gccaccttca ttggcaacag     1260

cacggccatc caggagctgt tcaagcgcat ctccgagcag ttcacggcca tgttccggcg     1320

caaggccttc ctgcactggt acacgggcga gggcatggac gagatggagt tcaccgaggc     1380

cgagagcaac atgaatgacc tggtgtccga gtaccagcag taccaggatg ccacagccga     1440

ggaggagggc gagttcgagg aggaggctga ggaggaggtg gcctagagcc ttcagtcact     1500

ggggaaagca gggaagcagt gtgaactctt tattcactcc cagcctgtcc tgtggcctgt     1560

cccactgtgt gcacttgctg ttttccctgt ccacatccat gctgtacaga caccaccatt     1620

aaagcatttt catagtg                                                    1637


<210> 1188
<211> 1432
<212> DNA
<213> Homo sapiens

<400> 1188
ttcccagtgt tctggcaggt aaggaacgcc ggctcttcgc ctctcagcgc ggcttgtcct       60

ttgttccgga cgcccgctcc tcagccctgc ggctcctggg gtcgctgctg catcccgcac      120

gcctccaccg gctgcagacc catggccgag cgcggggaac tcgacttgac cggcgccaaa      180

cagaacacag gagtgtggct agtcaaggtt cctaaatatt tgtcacagca atgggctaaa      240

gcctctggaa gaggtgaagt tgggaaactg cggattgcca agactcaagg aaggactgag      300

gtgtcattta ctttgaatga ggatcttgca aatattcatg atattggtgg aaaaccagct      360

tcagtcagtg ctcctagaga acatccattt gtcttgcaaa gtgttggagg acagacatta      420

acagtattta ctgagagctc atcagataag ctgtcattgg aaggaatagt ggtacaaaga      480

gctgaatgcc gaccagctgc cagtgaaaac tacatgcgat taaaaagatt gcaaatagaa      540

gagtcttcca aaccagtgag gctatcacaa cagctggaca aagttgtaac aaccaattac      600

aaacctgttg ctaatcatca atacaatatc gaatatgaaa ggaaaaagaa agaagacgga      660

aagcgagctc gagctgataa acaacatgtt ttagacatgc tattttcagc ctttgagaaa      720

catcaatact ataatcttaa ggacttggtg gacatcacaa agcaacctgt ggtgtacctg      780

aaggaaatct taaaagaaat tggtgttcag aatgtaaaag ggatccacaa aaacacatgg      840

gagctgaagc cagagtacag acactatcaa ggagaagaaa agagtgacta agaagactcc      900

tagccagcat gctagtgaaa cgactagcag cgatgctatg caaaaggcgc tgatactgga      960

aggcttgaac accgtatgtt aataggggtt aagtgacagt actttgattt ctctcggtaa     1020

attttttaaa cctgtaattc ttgtaaagtt tcttaactgt ttttttgagg agaaagaaca     1080

gatttattta tagacttaac ttgtattaaa ccagattatt cacagtagga ataggggttg     1140

gaggattaag agggtttttc ttaaatatta gcttttaatg tgtacaatta ggaaattttt     1200

ttaagtgagg actctctacc cttgccgtat ctaaggagct gaggtaatac agatccaagg     1260

agaattgtat agcaagaaaa aaacagtcaa ctacagaaac tcttaaaagg aataaaaacc     1320

caaagttcct tattttgaaa ttgtcaaaga acaaagcggt gtttttcttt taaacaggtg     1380

atcacgtttc gtgttcatac tcaacgttaa taaaaggaga gagtttgtag tg             1432


<210> 1189
<211> 6997
<212> DNA
<213> Homo sapiens

<400> 1189
atagtaggca atatttatgt gtcatttatt attattgcta ttagtgttac ctattatttt       60

ctttttgaac ccacttattg cctaattagt catagtttga caattgccct tgtattccac      120

catgtcaaat ataaatttac atagatgaag ctcctgaaat tattcttggg ttaccatttt      180

gtgaagctat tgatatgtgg tcactgggct gtgtgatagc tgagctgttc ctgggatggc      240

ctctttatcc tggtgcttca gaatatgatc agattcgtta tatttcacaa acacaaggct      300

tgccagctga atatcttctc agtgccggaa caaaaacaac caggtttttc aacagagatc      360

ctaatttggg gtacccactg tggaggctta agacacctga agaacatgaa ctggagactg      420

gaataaaatc aaaagaagct cggaagtaca tttttaattg cttagatgac atggctcagg      480

tgaatatgtc tacagacctg gagggaacag acatgttggc agagaaggca gaccgaagag      540

aatacattga tctgttaaag aaaatgctca caattgatgc agataagaga attacccctc      600

taaaaactct taaccatcag tttgtgacaa tgactcacct tttggatttt ccacatagca      660

atcatgttaa gtcttgtttt cagaacatgg agatctgcaa gcggagggtt cacatgtatg      720

atacagtgag tcagatcaag agtcccttca ctacacatgt tgccccaaat acaagcacaa      780

atctaaccat gagcttcagc aatcagctca atacagtgca caatcaggcc agtgttctag      840

cttccagttc tactgcagca gctgctactc tttctctggc taattcagat gtctcactac      900

taaactacca gtcagctttg tacccatcat ctgctgcacc agttcctgga gttgcccagc      960

agggtgtttc cttgcagcct ggaaccaccc agatttgcac tcagacagat ccattccaac     1020

agacatttat agtatgtcca cctgcgtttc aaactggact acaagcaaca acaaagcatt     1080

ctggattccc tgtgaggatg gataatgctg taccgattgt accccaggca ccagctgctc     1140

agccactaca gattcagtca ggagttctca cgcagggaag ctgtacacca ctaatggtag     1200

caactctcca ccctcaagta gccaccatca caccgcagta tgcggtgccc tttactctga     1260

gctgcgcagc cggccggccg gcgctggttg aacagactgc cgctgtactg caggcgtggc     1320

ctggagggac tcagcaaatt ctcctgcctt caacttggca acagttgcct ggggtagctc     1380

tacacaactc tgtccagccc acagcaatga ttccagaggc catggggagt ggacagcagc     1440

tagctgactg gaggaatgcc cactctcatg gcaaccagta cagcactatc atgcagcagc     1500

catccttgct gactaaccat gtgacattgg ccactgctca gcctctgaat gttggtgttg     1560

cccatgttgt cagacaacaa caatccagtt ccctcccttc gaagaagaat aagcagtcag     1620

ctccagtctc ttccaagtcc tctctagatg ttctgccttc ccaagtctat tctctggttg     1680

ggagcagtcc cctccgcacc acatcttctt ataattcctt ggtccctgtc caagatcagc     1740

atcagcccat catcattcca gatactccca gccctcctgt gagtgtcatc actatccgaa     1800

gtgacactga tgaggaagag gacaacaaat acaagcccag tagctctgga ctgaagccaa     1860

ggtctaatgt catcagttat gtcactgtca atgattctcc agactctgac tcttctttga     1920

gcagccctta ttccactgat accctgagtg ctctccgagg caatagtgga tccgttttgg     1980

aggggcctgg cagagttgtg gcagatggca ctggcacccg cactatcatt gtgcctccac     2040

tgaaaactca gcttggtgac tgcactgtag caacccaggc ctcaggtctc ctgagcaata     2100

agactaagcc agtcgcttca gtgagtgggc agtcatctgg atgctgtatc acccccacag     2160

ggtatcgagc tcaacgcggg gggaccagtg cagcacaacc actcaatctt agccagaacc     2220

agcagtcatc ggcggctcca acctcacagg agagaagcag caacccagcc ccccgcaggc     2280

agcaggcgtt tgtggcccct ctctcccaag ccccctacac cttccagcat ggcagcccgc     2340

tacactcgac agggcaccca caccttgccc cggcccctgc tcacctgcca agccaggctc     2400

atctgtatac gtatgctgcc ccgacttctg ctgctgcact gggctcaacc agctccattg     2460

ctcatctttt ctccccacag ggttcctcaa ggcatgctgc agcctatacc actcacccta     2520

gcactttggt gcaccaggtc cctgtcagtg ttgggcccag cctcctcact tctgccagcg     2580

tggcccctgc tcagtaccaa caccagtttg ccacccaatc ctacattggg tcttcccgag     2640

gctcaacaat ttacactgga tacccgctga gtcctaccaa gatcagccag tattcctact     2700

tatagttggt gagcatgagg gaggaggaat catggctacc ttctcctggc cctgcgttct     2760

taatattggg ctatggagag atcctccttt accctcttga aatttcttag ccagcaactt     2820

gttctgcagg ggcccactga agcagaaggt ttttctctgg gggaacctgt ctcagtgttg     2880

actgcattgt tgtagtcttc ccaaagtttg ccctattttt aaattcatta tttttgtgac     2940

agtaattttg gtacttggaa gagttcagat gcccatcttc tgcagttacc aaggaagaga     3000

gattgttctg aagttaccct ctgaaaaata ttttgtctct ctgacttgat ttctataaat     3060

gcttttaaaa acaagtgaag cccctcttta tttcattttg tgttattgtg attgctggtc     3120

aggaaaaatg ctgatagaag gagttgaaat ctgatgacaa aaaaagaaaa attacttttt     3180

gtttgtttat aaactcagac ttgcctattt tattttaaaa gcggcttaca caatctccct     3240

tttgtttatt ggacatttaa acttacagag tttcagtttt gttttaatgt catattatac     3300

ttaatgggca attgttattt ttgcaaaact ggttacgtat tactctgtgt tactattgag     3360

attctctcaa ttgctcctgt gtttgttata aagtagtgtt taaaaggcag ctcaccattt     3420

gctggtaact taatgtgaga gaatccatat ctgcgtgaaa acaccaagta ttctttttaa     3480

atgaagcacc atgaattctt ttttaaatta ttttttaaaa gtctttctct ctctgattca     3540

gcttaaattt ttttatcgaa aaagccatta aggtggttat tattacatgg tggtggtggt     3600

tttattatat gcaaaatctc tgtctattat gagatactgg cattgatgag ctttgcctaa     3660

agattagtat gaattttcag taatacacct ctgttttgct catctctccc ttctgtttta     3720

tgtgatttgt ttggggagaa agctaaaaaa acctgaaacc agataagaac atttcttgtg     3780

tatagctttt atacttcaaa gtagcttcct ttgtatgcca gcagcaaatt gaatgctctc     3840

ttattaagac ttatataata agtgcatgta ggaattgcaa aaaatatttt aaaaatttat     3900

tactgaattt aaaaatattt tagaagtttt gtaatggtgg tgttttaata ttttacataa     3960

ttaaatatgt acatattgat tagaaaaata taacaagcaa tttttcctgc taacccaaaa     4020

tgttatttgt aatcaaatgt gtagtgatta cacttgaatt gtgtacttag tgtgtatgtg     4080

atcctccagt gttatcccgg agatggattg atgtctccat tgtatttaaa ccaaaatgaa     4140

ctgatacttg ttggaatgta tgtgaactaa ttgcaattat attagagcat attactgtag     4200

tgctgaatga gcaggggcat tgcctgcaag gagaggagac ccttggaatt gttttgcaca     4260

ggtgtgtctg gtgaggagtt tttcagtgtg tgtctcttcc ttccctttct tcctccttcc     4320

cttattgtag tgccttatat gataatgtag tggttaatag agtttacagt gagcttgcct     4380

taggatggac cagcaagccc ccgtggaccc taagttgttc accgggattt atcagaacag     4440

gattagtagc tgtattgtgt aatgcattgt tctcagtttc cctgccaaca ttgaaaaata     4500

aaaacagcag cttttctcct ttaccaccac ctctacccct ttccattttg gattctcggc     4560

tgagttctca cagaagcatt ttccccatgt ggctctctca ctgtgcgttg ctaccttgct     4620

tctgtgagaa ttcaggaagc aggtgagagg agtcaagcca atattaaata tgcattcttt     4680

taaagtatgt gcaatcactt ttagaatgaa tttttttttc cttttcccat gtggcagtcc     4740

ttcctgcaca tagttgacat tcctagtaaa atatttgctt gttgaaaaaa acatgttaac     4800

agatgtgttt ataccaaaga gcctgttgta ttgcttacca tgtccccata ctatgaggag     4860

aagttttgtg gtgccgctgg tgacaaggaa ctcacagaaa ggtttcttag ctggtgaaga     4920

atatagagaa ggaaccaaag cctgttgagt cattgaggct tttgaggttt cttttttaac     4980

agcttgtata gtcttggggc ccttcaagct gtgaaattgt ccttgtactc tcagctcctg     5040

catggatctg ggtcaagtag aaggtactgg ggatggggac attcctgccc ataaaggatt     5100

tggggaaaga agattaatcc taaaatacag gtgtgttcca tctgaattga aaatgatata     5160

tttgagatat aattttagga ctggttctgt gtagatagag atggtgtcaa ggaggtgcag     5220

gatggagatg ggagatttca tggagcctgg tcagccagct ctgtaccagg ttgaacaccg     5280

aggagctgtc aaagtatttg gagtttcttc attgtaagga gtaagggctt ccaagatggg     5340

gcaggtagtc cgtacagcct accaggaaca tgttgtgttt tctttatttt ttaaaatcat     5400

tatattgagt tgtgttttca gcactatatt ggtcaagata gccaagcagt ttgtataatt     5460

tctgtcacta gtgtcataca gttttctggt caacatgtgt gatctttgtg tctccttttt     5520

gccaagcaca ttctgatttt cttgttggaa cacaggtcta gtttctaaag gacaaatttt     5580

ttgttccttg tcttttttct gtaagggaca agatttgttg tttttgtaag aaatgagatg     5640

caggaaagaa aaccaaatcc cattcctgca ccccagtcca ataagcagat accacttaag     5700

ataggagtct aaactccaca gaaaaggata ataccaagag cttgtattgt taccttagtc     5760

acttgcctag cagtgtgtgg ctttaaaaac tagagatttt tcagtcttag tctgcaaact     5820

ggcatttccg attttccagc ataaaaatcc acctgtgtct gctgaatgtg tatgtatgtg     5880

ctcactgtgg ctttagattc tgtccctggg gttagccctg ttggccctga caggaaggga     5940

ggaagcctgg tgaatttagt gagcagctgg cctgggtcac agtgacctga cctcaaacca     6000

gcttaaggct ttaagtcctc tctcagaact tggcatttcc aacttcttcc tttccgggtg     6060

agagaagaag cggagaaggg ttcagtgtag ccactctggg ctcataggga cacttggtca     6120

ctccagagtt tttaatagct cccaggaggt gatattattt tcagtgctca gctgaaatac     6180

caaccccagg aataagaact ccatttcaaa cagttctggc cattctgagc ctgcttttgt     6240

gattgctcat ccattgtcct ccactagagg ggctaagctt gactgccctt agccaggcaa     6300

gcacagtaat gtgtgttttg ttcagcatta ttatgcaaaa attcactagt tgagatggtt     6360

tgttttagga taggaaatga aattgcctct cagtgacagg agtggcccga gcctgcttcc     6420

tattttgatt tttttttttt ttaactgata gatggtgcag catgtctaca tggttgtttg     6480

ttgctaaact ttatataatg tgtggtttca attcagcttg aaaaataatc tcactacatg     6540

tagcagtaca ttatatgtac attatatgta atgttagtat ttctgctttg aatccttgat     6600

attgcaatgg aattcctact ttattaaatg tatttgatat gctagttatt gtgtgcgatt     6660

taaacttttt ttgctttctc cctttttttg gttgtgcgct ttcttttaca acaagcctct     6720

agaaacagat agtttctgag aattactgag ctatgtttgt aatgcagatg tacttaggga     6780

gtatgtaaaa taatcatttt aacaaaagaa atagatattt aaaatttaat actaactatg     6840

ggaaaagggt ccattgtgta aaacatagtt tatctttgga ttcaatgttt gtctttggtt     6900

ttacaaagta gcttgtattt tcagtatttt ctacataata tggtaaaatg tagagcaatt     6960

gcaatgcatc aataaaatgg gtaaattttc tgactta                              6997


<210> 1190
<211> 3605
<212> DNA
<213> Homo sapiens

<400> 1190
tcaaaatttc aacgatactg aatgagtccc gcggcgggtt ggctcgcgct tcgttgtcag       60

atctgaggcg aggctaggtg agccgtggga agaaaagagg gagcagctag ggcgcgggtc      120

tccctcctcc cggagtttgg aacggctgaa gttcaccttc cagcccctag cgccgttcgc      180

gccgctaggc ctggcttctg aggcggttgc ggtgctcggt cgccgcctag gcggggcagg      240

gtgcgagcag gggcttcggg ccacgcttct cttggcgaca ggattttgct gtgaagtccg      300

tccgggaaac ggaggaaaaa aagagttgcg ggaggctgtc ggctaataac ggttcttgat      360

acatatttgc cagacttcaa gatttcagaa aaggggtgaa agagaagatt gcaactttga      420

gtcagacctg taggcctgat agactgatta aaccacagaa ggtgacctgc tgagaaaagt      480

ggtacaaata ctgggaaaaa cctgctcttc tgcgttaagt gggagacaat gtcacaagtt      540

aaaagctctt attcctatga tgccccctcg gatttcatca atttttcatc cttggatgat      600

gaaggagata ctcaaaacat agattcatgg tttgaggaga aggccaattt ggagaataag      660

ttactgggga agaatggaac tggagggctt tttcagggca aaactccttt gagaaaggct      720

aatcttcagc aagctattgt cacacctttg aaaccagttg acaacactta ctacaaagag      780

gcagaaaaag aaaatcttgt ggaacaatcc attccgtcaa atgcttgttc ttccctggaa      840

gttgaggcag ccatatcaag aaaaactcca gcccagcctc agagaagatc tcttaggctt      900

tctgctcaga aggatttgga acagaaagaa aagcatcatg taaaaatgaa agccaagaga      960

tgtgccactc ctgtaatcat cgatgaaatt ctaccctcta agaaaatgaa agtttctaac     1020

aacaaaaaga agccagagga agaaggcagt gctcatcaag atactgctga aaagaatgca     1080

tcttccccag agaaagccaa gggtagacat actgtgcctt gtatgccacc tgcaaagcag     1140

aagtttctaa aaagtactga ggagcaagag ctggagaaga gtatgaaaat gcagcaagag     1200

gtggtggaga tgcggaaaaa gaatgaagaa ttcaagaaac ttgctctggc tggaataggg     1260

caacctgtga agaaatcagt gagccaggtc accaaatcag ttgacttcca cttccgcaca     1320

gatgagcgaa tcaaacaaca tcctaagaac caggaggaat ataaggaagt gaactttaca     1380

tctgaactac gaaagcatcc ttcatctcct gcccgagtga ctaagggatg taccattgtt     1440

aagcctttca acctgtccca aggaaagaaa agaacatttg atgaaacagt ttctacatat     1500

gtgccccttg cacagcaagt tgaagacttc cataaacgaa cccctaacag atatcatttg     1560

aggagcaaga aggatgatat taagacaggg tcttgctccg tcacccaggc tggagtgcag     1620

tggcgtgatc atggctcact tcagtgtcca actcctgggc tcaagcaatc ctcctgcctt     1680

agccttccaa acctgttacc ctccaaatct tctgtgacca agatttgcag agacccacag     1740

actcctgtac tgcaaaccaa acaccgtgca cgggctgtga cctgcaaaag tacagcagag     1800

ctggaggctg aggagctcga gaaattgcaa caatacaaat tcaaagcacg tgaacttgat     1860

cccagaatac ttgaaggtgg gcccatcttg cccaagaaac cacctgtgaa accacccacc     1920

gagcctattg gctttgattt ggaaattgag aaaagaatcc aggagcgaga atcaaagaag     1980

aaaacagagg atgaacactt tgaatttcat tccagacctt gccctactaa gattttggaa     2040

gatgttgtgg gtgttcctga aaagaaggta cttccaatca ccgtccccaa gtcaccagcc     2100

tttgcattga agaacagaat tcgaatgccc accaaagaag atgaggaaga ggacgaaccg     2160

gtagtgataa aagctcaacc tgtgccacat tatggggtgc cttttaagcc ccaaatccca     2220

gaggcaagaa ctgtggaaat atgccctttc tcgtttgatt ctcgagacaa agaacgtcag     2280

ttacagaagg agaagaaaat aaaagaactg cagaaagggg aggtgcccaa gttcaaggca     2340

cttcccttgc ctcattttga caccattaac ctgccagaga agaaggtaaa gaatgtgacc     2400

cagattgaac ctttctgctt ggagactgac agaagaggtg ctctgaaggc acagacttgg     2460

aagcaccagc tggaagaaga actgagacag cagaaagaag cagcttgttt caaggctcgt     2520

ccaaacaccg tcatctctca ggagcccttt gttcccaaga aagagaagaa atcagttgct     2580

gagggccttt ctggttctct agttcaggaa ccttttcagc tggctactga gaagagagcc     2640

aaagagcggc aggagctgga gaagagaatg gctgaggtag aagcccagaa agcccagcag     2700

ttggaggagg ccagactaca ggaggaagag cagaaaaaag aggagctggc caggctacgg     2760

agagaactgg tgcataaggc aaatccaata cgcaagtacc agggtctgga gataaagtca     2820

agtgaccagc ctctgactgt gcctgtatct cccaaattct ccactcgatt ccactgctaa     2880

actcagctgt gagctgcgga taccgcccgg caatgggacc tgctcttaac ctcaaaccta     2940

ggaccgtctt gctttgtcat tgggcatgga gagaacccat ttctccagac ttttacctac     3000

ccgtgcctga gaaagcatac ttgacaactg tggactccag ttttgttgag aattgttttc     3060

ttacattact aaggctaata atgagatgta actcatgaat gtctcgatta gactccatgt     3120

agttacttcc tttaaaccat cagccggcct tttatatggg tcttcactct gactagaatt     3180

tagtctctgt gtcagcacag tgtaatctct attgctattg ccccttacga ctctcaccct     3240

ctccccactt tttttaaaaa ttttaaccag aaaataaaga tagttaaatc ctaagataga     3300

gattaagtca tggtttaaat gaggaacaat cagtaaatca gattctgtcc tcttctctgc     3360

ataccgtgaa tttatagtta aggatccctt tgctgtgagg gtagaaaacc tcaccaactg     3420

caccagtgag gaagaagact gcgtggattc atggggagcc tcacagcagc cacgcagcag     3480

gctctgggtg gggctgccgt taaggcacgt tctttcctta ctggtgctga taacaacagg     3540

gaaccgtgca gtgtgcattt taagacctgg cctggaataa atacgttttg tctttccctc     3600

cctga                                                                 3605


<210> 1191
<211> 2789
<212> DNA
<213> Homo sapiens

<400> 1191
gggaggagcc atcccagcca tgagcccctg tgggaatctg ctgggggcca agtggcctgg       60

agtcctcagg ctcccgcagc tgctccggag ggagaggtga gctcagggca gcctgcctgc      120

agccagaggt gccgggagcc ccgggcctgt catggtggcc atctacagcc ggcctgaggc      180

agtcacagac ggatttgcag ctgagcctgt ctatctggtg tgggaagaag atggggagtt      240

acttgtcagt cccggcttac ttcacctcca gagacctgtt tcggtgttca gaatgccagg      300

attccctcac caactggtac tatgagaagg atgggaagct ctactgcccc aaggactact      360

gggggaagtt tggggagttc tgtcatgggt gctccctgct gatgacaggg ccttttatgg      420

tggctgggga gttcaagtac cacccagagt gctttgcctg tatgagctgc aaggtgatca      480

ttgaggatgg ggatgcatat gcactggtgc agcatgccac cctctactgt gggaagtgcc      540

acaatgaggt ggtgctggca cccatgtttg agagactctc cacagagtct gttcaggagc      600

agctgcccta ctctgtcacg ctcatctcca tgccggccac cactgaaggc aggcggggct      660

tctccgtgtc cgtggagagt gcctgctcca actacgccac cactgtgcaa gtgaaagagg      720

tcaaccggat gcacatcagt cccaacaatc gaaacgccat ccaccctggg gaccgcatcc      780

tggagatcaa tgggaccccc gtccgcacac ttcgagtgga ggaggtggag gatgcaatta      840

gccagacgag ccagacactt cagctgttga ttgaacatga ccccgtctcc caacgcctgg      900

accagctgcg gctggaggcc cggctcgctc ctcacatgca gaatgccgga cacccccacg      960

ccctcagcac cctggacacc aaggagaatc tggaggggac actgaggaga cgttccctaa     1020

ggcgcagtaa cagtatctcc aagtcccctg gccccagctc cccaaaggag cccctgctgt     1080

tcagccgtga catcagccgc tcagaatccc ttcgttgttc cagcagctat tcacagcaga     1140

tcttccggcc ctgtgaccta atccatgggg aggtcctggg gaagggcttc tttgggcagg     1200

ctatcaaggt gacacacaaa gccacgggca aagtgatggt catgaaagag ttaattcgat     1260

gtgatgagga gacccagaaa acttttctga ctgaggtgaa agtgatgcgc agcctggacc     1320

accccaatgt gctcaagttc attggtgtgc tgtacaagga taagaagctg aacctcctga     1380

cagagtacat tgaggggggc acactgaagg actttctgcg cagtatggat ccgttcccct     1440

ggcagcagaa ggtcaggttt gccaaaggaa tcgcctccgg aatggcctat ttgcactcta     1500

tgtgcatcat ccaccgggat ctgaactcgc acaactgcct catcaagttg gacaagactg     1560

tggtggtggc agactttggg ctgtcacggc tcatagtgga agagaggaaa agggccccca     1620

tggagaaggc caccaccaag aaacgcacct tgcgcaagaa cgaccgcaag aagcgctaca     1680

cggtggtggg aaacccctac tggatggccc ctgagatgct gaacggaaag agctatgatg     1740

agacggtgga tatcttctcc tttgggatcg ttctctgtga gatcattggg caggtgtatg     1800

cagatcctga ctgccttccc cgaacactgg actttggcct caacgtgaag cttttctggg     1860

agaagtttgt tcccacagat tgtcccccgg ccttcttccc gctggccgcc atctgctgca     1920

gactggagcc tgagagcaga gccccccccg gggccgcagg agagggcccg ggctgcgcgg     1980

atgatgaggg cccagtgagg cgccaaggga aggtcaccat caagtatgac cccaaggagc     2040

tacggaagca cctcaaccta gaggagtgga tcctggagca gctcacgcgc ctctacgact     2100

gccaggaaga ggagatctca gaactagaga ttgacgtgga tgagctcctg gacatggaga     2160

gtgacgatgc ctgggcttcc agggtcaagg agctgctggt tgactgttac aaacccacag     2220

aggccttcat ctctggcctg ctggacaaga tccgggccat gcagaagctg agcacacccc     2280

agaagaagtg agggtccccg acccaggcga acggtggctc ccataggaca atcgctaccc     2340

cccgacctcg tagcaacagc aataccgggg gaccctgcgg ccaggcctgg ttccatgagc     2400

agggctcctc gtgcccctgg cccaggggtc tcttcccctg ccccctcagt tttccacttt     2460

tggatttttt tattgttatt aaactgatgg gactttgtgt ttttatattg actctgcggc     2520

acgggccctt taataaagcg aggtagggta cgcctttggt gcagctcaaa aaaaaaaaaa     2580

aaaatgattt ccagcggtcc acattagagt tgaaattttc tggtgggaga atctatacct     2640

tgttccttta taggccaagg accgcagtcc ttcagtaaca ccagtgtaaa agcttgagga     2700

gaaattgtga agctacacag tatttgtttt ctaatacctc ttgtcattct aaatatcttt     2760

aatttattaa aaaatatata tatacagta                                       2789


<210> 1192
<211> 2188
<212> DNA
<213> Homo sapiens

<400> 1192
agaggcaggt gagcgcgatg cagccggcgc cgggtctggg gctcggggac tcctccctgc       60

accgctacct ggacggcgac ttctggagcc tcaagaacga gctgcgcgga ctcctcggcg      120

gcgcccgctc ttccggcaaa ggtatgattt aagcttggat gaaatgagag ctttgacagt      180

tcagagagtg aagtttgcca tggacctgcc tctgttaaaa cgtgcaggtc aggatctggc      240

agagaaaaca aagaattttg tcagccgaag ccttgtcata ggagaagtcc tctccatggc      300

ggacatggcc acaggagtga agtgcggaat aatttattgg ctatttggtg gtgctatcag      360

gaatctcgga agccctgaac atgttactaa gtggtttcag ccactccagg agcagaaata      420

cactgggatg tttgcaatga ccgagagggg ccatgggagc aacgcgagag ggatccagac      480

cgaagccacc tttgacctct ctgcccagga gtttgtaatt gacacgccgt gtgaaaatgc      540

ggagaagatg tatattggaa atgccatgta cgggaattat gcagctgtct ttgcccagct      600

catcatagat ggaagatctc aagggcccca ctgtttcatc gttcctgtcc gggatgaaaa      660

cggaagcttg tacccaggag tcacagctat tgatatgatg tacaaggagg gtctgcatgg      720

tgtggacaat gggatattaa tatttgacaa ggttcggata cccagggaga acctgctgga      780

taagtttggt tccgtggctc cagatggaca gtaccattcg cctattagga acaagagtgc      840

aagattcaat gccatgctgg cagcactgac cccttcgaga ttagctgtgg ctttccaagc      900

tatgggtgcc atgaagcttg ggttgacgat agccattcgc tatagccaca ggtccagaat      960

catctcccag aactgctgtt cagctccagc tggtctttat tgagcccctc ttgtggacca     1020

ggctaatttc ctgaaaactg gtttttgcta acgtttctta cgcttgctcg tgaaatcagc     1080

cacttaactg ttctgggttt tcccgtggca gatccctata ggcttctcac tgcactatcc     1140

caaacttttt atctgagaat gttgtgtggc aagatgtctg cagagtgccg cttaggagat     1200

gctggcctgg cgtccacggg tctgctgtgt atgtctctcc aggcagatgg cctgtctctg     1260

cctggcaagg acgatctggg gtggaaaaac tctgatctga aagtgaaatc attgactccg     1320

ttaccatgtt ctgaattccc agatctccct gatatggaaa gtgaaaattg gcttctatta     1380

cacaatgcat caaaattctt ttgtatagga ccagaccact gatatcaagg gcagtgcact     1440

gactttcagt tcctctgcat cccttggtca tgttcccacc tttcaatggg aacagagaat     1500

aaaaattcca gctctagggc ccagcctagt ggccacctct cacggacagg cacccggctg     1560

ctcagtgtta tccaattact agaggccatt cctagcattt caacttgggg aattaattta     1620

ctattacttt atttttatct ttagagacag agtcttgctc tgtcacccag actagagtgt     1680

agtggcatga tcatagctca ctgcagcctt gaactcctga gctcaggcaa tcctcctgcc     1740

acagccacct gagtagctgg aactataggc atgtgccatc atgcccaact aattttattt     1800

ttatttcagt tgtagagatg gagccttacc ctgttgccca ggctggtctc tgactcctgg     1860

tctctagtga tcctcctgcc ttggcctccc aaagtgctag gattataggt gtgagccaac     1920

atgctgtccc cattattgac tgttacccta aagtgtgtgt tgcctttcta gtttgagtag     1980

aaagtccagc attatctttt tggataatat ccaggttttg ctgtttcttt ctttattttt     2040

cataatgaga acatttgctc tcttgctgac attggagggc gtctgtttac ctctcctgta     2100

ggcacacaaa attcccaacg tttatttgaa gaaaaagaca attatttgag taatttgaat     2160

aaataaacat tttaagtgat tcccaaaa                                        2188


<210> 1193
<211> 2761
<212> DNA
<213> Homo sapiens

<400> 1193
cttcccatag ccgcggcctc aactaaaagt ggccattgac ctttcaagct ttcgagcagt       60

gatgcaatag aatagtattt caaagaaaaa tgcttatcga aattttggat ccggttttcc      120

cgtgattgtt aagggtttct tttaaaaagt aggtcacatt tcaagtaggt catatttcgg      180

gggcgggtgc gcagacaagg agatgagttt ccactaaggc cagggggcct ccaacggggt      240

tggaggtgag aatcccaggt agggtagagg tgccgagatc cttccgaatc ccagccctgg      300

ggcgtcagcc ctgcagggaa tggcagagac actctccgga ctgagggaac cgaggccagt      360

caccaagccc cttccgggcg cgcaggcgat cagtgggtga ccgcggctgc gagggacttt      420

gtcatccgtc ctccaggatc tggggagaaa gagccccatc ccttctctct ctgccaccat      480

ttcggacacc ccgcagggac tcgttttggg attcgcactg acttcaagga aggacgcgaa      540

cccttctctg accccagctc gggcggccac ctgtctttgc cgcggtgacc cttctctcat      600

gaccctgcgg tgccttgagc cctccgggaa tggcggggaa gggacgcgga gccagtgggg      660

gaccgcgggg tcggcggagg agccatcccc gcaggcggcg cgtctggcga aggccctgcg      720

ggagctcggt cagacaggat ggtactgggg aagtatgact gttaatgaag ccaaagagaa      780

attaaaagag gcaccagaag gaactttctt gattagagat agctcgcatt cagactacct      840

actaacaata tctgttaaaa catcagctgg accaactaat cttcgaatcg aataccaaga      900

cggaaaattc agattggact ctatcatatg tgtcaaatcc aagcttaaac aatttgacag      960

tgtggttcat ctgatcgact actatgttca gatgtgcaag gataagcgga caggtccaga     1020

agccccccgg aacggcactg ttcaccttta tctgaccaaa ccgctctaca cgtcagcacc     1080

atctctgcag catctctgta ggctcaccat taacaaatgt accggtgcca tctggggact     1140

gcctttacca acaagactaa aagattactt ggaagaatat aaattccagg tataaatgtt     1200

tctctttttt taaacatgtc tcacatagag tatctccgaa tgcagctatg taaaagagaa     1260

ccaaaacttg agtgctctgg ataactatat ggaatgcttt ctaagaacag ctgaagctaa     1320

tctaatttaa atttaacagc ttgaagaggt agctaggtgt ttaaagttcc tccagatact     1380

tttacctgag tgatgcttcc cttcctaagg ctgaccaaga cctgttgatc cttttagatt     1440

aaaaataaaa tgtcgcatgt aaaggctgaa gtcgcgtttt atcagaatgc cttgccttct     1500

taggttcttt tccattatgt caaaggtcca ggctccagta ggagagaaag aactcctcat     1560

aggaatactg aagaagtggg aaggaaccaa gctgacacag gcctcactgc aatttgatat     1620

gcctgctgat cagagtctct tgggcatttt atattttgca ttctgatgta cctaggagtt     1680

ttgttaaaca gatgatgtat gtgagtattt atcccatttt atgcaattaa ccaaatcaac     1740

caaaaaaagt gaccatgaag tcctgtattt gtctttttac tacatgtagg aactctcatg     1800

tgaatgagta ctgtagtaat ccattctatg ggagccttat ttcagaaata tttcaaactg     1860

gtgcaaatgg aaaagacttt ctcttttcct ttaaagctaa agacaagaat atcatgctat     1920

acaggtgcaa ctcaatcccc gttaataaaa accaatgtag gtataggcat tctacccttt     1980

gaaatagctg tgtcccaacc tgttgccatt gattttttgg aaatggcttt agaaatatcc     2040

aagttgtcct tgaattgtct aaccatggac ataaacagtt gtctcccttc tactgtgtag     2100

aatactttga cttaattttc ttccagatac agggggatac ctgcctgttt ttcaaagtgt     2160

ttatttactg ctgttactat ttgattagaa tgtattaaat aaaaaaaacc tgatttctac     2220

aagttgcact tattgagttc tagagaacgt acactttcat ggtaatagag gattgccata     2280

aaaacttacg tcaagtgaaa taagccaatt attcaacaaa aggtagaaca ttacttgcca     2340

ttctgtaaag ttatgggctg tacctgcccc ctttgcaatt tggaaagcat ggtttagaaa     2400

ctacaggcat tgtcaagtgg ccgggtcttt tataatttga ataggcataa cactgatgtc     2460

ctctgtgttt ccaaaaacat ggtttagaaa ctacaaacat tatgacatgg ccagtctttt     2520

acaagttgag taggcataat actaaagaaa aatacaaagt tttgtggcca cttatttttt     2580

gctatgttag tctgcataac tgttataaat gtaccatctt ttctagagtc cagacattat     2640

ttattttatg gctttaaaat tttcctgcat agctacaatc ctgtggtgtg tcaccataaa     2700

ggtggaccct gtgtgaatga gaaaattcag ttataaattg taataaaacc tgcttactgg     2760

a                                                                     2761


<210> 1194
<211> 1765
<212> DNA
<213> Homo sapiens

<400> 1194
aaagtggcga gagccacctc ggcgcttggg cgctcagtcg caggaggcgc tccttggcgg       60

tgcctggagc ccgggcgcac cccaccgctc ccgggacctg ttgggggctg gcccgaaccg      120

tcgtcgaagg gagccgctcg gccacccccg acgttcctcg ccccgcccga cgttccctca      180

agtggccgaa ccagccggac gagccaaact cgccgggcct cccggcggca gcaggtggcc      240

ccgtccttcc agggagggcc ctgcgccccg cggcgctccg gagccctctc ggccgccccc      300

gccaggcggg atggaggcgg atggggacgg agaggagctg gcccggctgc gctcagtctt      360

cgccgcctgc gacgcgaacc gctcggggcg cctggagcgc gaggagttcc gggcactgtg      420

cacggagctg cgggtgcggc cggccgacgc cgaggcagta ttccagcggc tggacgccga      480

ccgtgacggc gccatcacct tccaggagtt cgcgcgtggc ttcctcgggt ccctccgcgg      540

ggggcggcgc cgggactggg gtcctctgga tcccgcgccc gccgtgtctg aggcggggcc      600

ggagacacac gacagcgagg aggacgaagg cgacgaggac gcggcggcgg cgctggccac      660

ctcgtgcggc ccggcgagtc ccggccgggc ttggcaggat ttccaggcgc gacttgggga      720

cgaagccaag ttcattccca gatttggcta cacaatttca aaacctgcat ttgtgttcgt      780

gaggcatctc ataacactgt gtgcattgtc atgggctaaa aaggaaggca gagaaacact      840

ttggacaatc gaggagggag gagccaagat ggccgaatag gaacagctcc ggtctacagc      900

tcccagcgtg agcgacgcag aagacgggtg atttctgcat ttccatctga ggtaccgggt      960

tcatctcact acggagtgcg agacagtggg cgcaggccag tgtgtgcgcg caccgtgcgc     1020

gagccgaagc agggcgaggc attgcctcac ctgggaagcg caaggggtca gggagttccc     1080

tttccgagtc aaagaaaggg gtgacggacg cacctggaaa atcgggtcac tcccacccga     1140

atattgcgct tttcagaccg gcttaagaaa cggcgcacca caagactata tcccacacct     1200

ggctcagagg gtcctacgcc cacggaatct cgctgattgc tagcacagca gtctgagatc     1260

aaactgcaag gcggcaacga ggctggggga ggggcgcccg ccattgccca ggcttgctta     1320

ggtaaacaaa gcagcctgga agctcgaact gggtggagcc caccacagct caaggaggcc     1380

tgcctgcctc tgtaggctcc acctctgggg gcagggcaca gacaaacaaa aagacagcag     1440

taacctctgc agacttaagt gtccctgtct gacagctttg aagagagcag tggttctccc     1500

agcacgcaga tggagatctg agaacgggca gactgcctcc tcaagtgggt ccctgacccc     1560

tgacccccaa gcagcctaac tgggaggcac cccccaacag gggcacactg acacctcaca     1620

cggcagggta ttccaacaga cctgcagctg agggtcctgt ctgttagaag gaaaactaac     1680

aaccagaaag gacatctaca ccgaaaaccc atctgtacat caccatcatc aaagaccaaa     1740

agtagataaa accacaaaga tgggg                                           1765


<210> 1195
<211> 986
<212> DNA
<213> Homo sapiens

<400> 1195
gcccttgacg tagcagtaaa aaccttcccc cctgagagac acgtggcagt gaagtgtttt       60

ggaaaaaaaa aggaaaaaaa aaacaatgcc aacagcccag cgtccgtgag caacccaaca      120

gtaacaaagc atgcgttcgg gatggaggaa gaacttcagc gagagggaag catcgagact      180

ctgagtaaca gctcaggctc caccagcggc agcataccaa gaaactttga tggctaccga      240

tctccgctgc ccaccaatga gagccagccc ctcagcctct tcccgactgg cttcccgtag      300

gtaccagcaa cctgcttctg actggccagc cccctcccct gctggaggag gggagaagcc      360

ccgctctggt cctacccttc agtctctgct cttccttcat caaccacctt ccccaagctt      420

agtgacagca gccgcccatc ctacctggat ggagaagaga cccttctcca agcacctcag      480

cgcacttgcc ctctgccaca cctgtcggtg gaggctgtgg ccaggagaga ctgtagaagc      540

tcggtccctg tgtatgtttg catatgacat cctgcattgg atccgctttt gtatttttta      600

accataccca cggtggggcg ggtgggggga gcctggaaca gtgaccagat ctgggggcct      660

gagtggggac agagttgatc gtccacctgg ccattttgac cctgagtgga cagtcacagc      720

ctcagctcat gtctggctgt gacacacact gcccccagct tcccttggtc agccccactc      780

cagcacgggg tgaacggagg cccagagtac tagggaagga ggaagggagg acatgcctct      840

tcttcctcct ttctttcccc atctgttcat gggaagagtt tgtctttctt atctttaagc      900

ccctttaccc tggtcctgta ctgatcagtg aaggaaaccg tggttactga ggccctgttg      960

aaaagtgcac gtcttgtcca ataaat                                           986


<210> 1196
<211> 1701
<212> DNA
<213> Homo sapiens

<400> 1196
cgggagcagc ggccgcaggc gccatggctg cggagcggac ccggccgctg caaggctctg       60

gcggtccgag cgtgcctagt agctgtgaac ccggcgcgag gtcccgggcc ccggggcgct      120

cgctcaggta aatttttcca taaccttatg gagagaaagg actttgagac atggcttgat      180

aacatttctg ttacatttct ttctctgacg gacttgcaga aaaatgaaac tctggatcac      240

ctgattagtc tgagtggggc agtccagctc aggcatctct ccaataacct agagactctc      300

ctcaagcggg acttcctcaa actccttccc ctggagctca gtttttattt gttaaaatgg      360

ctcgatcctc agactttact cacatgctgc ctcgtctcta aacagtggaa taaggtgata      420

agtgcctgta cagaggtgtg gcagactgca tgtaaaaatt tgggctggca gatagatgat      480

tctgttcagg acgctttgca ctggaagaag gtttatttga aggctatttt gagaatgaag      540

caactggagg accatgaagc ctttgaaacc tcgtcattaa ttggacacag tgccagagtg      600

tatgcacttt actacaaaga tggacttctc tgtacagtat ttagcgtgga ctacaatgat      660

gaactggata tcttggtgag cggctctgca gacttcactg tgaaagtatg ggctttatct      720

gctgggacat gcctgaacac actcaccggg cacacggaat gggtcaccaa ggtagttttg      780

cagaagtgca aagtcaagtc tctcttgcac agtcctggag actacatcct cttaagtgca      840

gacaaatatg agattaagat ttggccaatt gggagagaaa tcaactgtaa gtgcttaaag      900

acattgtctg tctctgagga tagaagtatc tgcctgcagc caagacttca ttttgatggc      960

aaatacattg tctgtagttc agcacttggt ctctaccagt gggactttgc cagttatgat     1020

attctcaggg tcatcaagac tcctgagata gcaaacttgg ccttgcttgg ctttggagat     1080

atctttgccc tgctgtttga caaccgctac ctgtacatca tggacttgcg gacagagagc     1140

ctgattagtc gctggcctct gccagagtac aggaaatcaa agagaggctc aagcttcctg     1200

gcaggcgaag catcctggct gaatggactg gatgggcaca atgacacggg cttggtcttt     1260

gccaccagca tgcctgacca cagtattcac ctggtgttgt ggaaggagca cggctgacac     1320

catgagccac caccgctgac tgactttggg tgccggggct gcgggttttg ggtgcaacct     1380

ctgcggcagc cgactgcatg aaccaaagtt ctcacctaat ggtatcatca cgcagtgcac     1440

aatcatttat ctatgttttg ccaggggcca gggctcgggg tgggggaggg cttgttttat     1500

tgacatacaa cgcagcatgc taatggggta caccattgac ttcatttgta cttagttatg     1560

ttggtcagtg ttagaggatg cattttgggt tcatctttct tgagtggagt attggtttta     1620

agtaaagaaa gttaaatgat ccattaatct gctaattggt tgcctatgaa atcacattgt     1680

ctgttattaa agctttttac c                                               1701


<210> 1197
<211> 4211
<212> DNA
<213> Homo sapiens

<400> 1197
gactgggagc aggcagcccg ggcggagcgg gccggtgccg aggacggccc caggcattgc       60

tctgccccgg gcattgcgcg gcgcgcgtga gggggatgcg gcaggaggcg gcgcggcggg      120

aggagtaggc ggcggcgccc tcgggaggga gctgcgcgcg ggccagacgg cgcccggagg      180

ctccgcagtg ccgccgccgt cgcccgggag gctccgcgcg ggagccatgt aaccctgcgg      240

cgggctccgg gctgctccgt ccttccccag ctcccgggct agcgcggcag cggggccacg      300

atgaagaagc agttcaatcg catgcgccag ctggccaacc agacggtggg cagggctgaa      360

aagacagaag ttttgagtga agaccttctt caggtggaga agcgtctgga gctggtgaaa      420

caggtgtccc acagcacgca caagaagctc accgcatgtc tgcagggcca gcaaggggca      480

gaggctgaca agcgctccaa aaagttgcct ttgacaacac tggctcagtg tctgatggag      540

gggtcagcta tcctgggaga tgacacactt cttgggaaga tgctgaaact ctgtggagag      600

acggaggaca agctggctca ggagctgata cattttgagt tgcaagtaga gagagacgtg      660

attgagcccc tgtttttgct ggcggaggtg gaaatcccaa atattcaaaa gcagaggaaa      720

cacttagcca agttggtgct ggacatggat tcctcacgaa ccaggtggca gcagacttcc      780

aagtcttcag gtttgtccag cagcttacag cctgcgggtg ccaaggctga tgccctcagg      840

gaagaaatgg aagaggctgc caacagagtg gagatttgca gggaccagct ctcagctgat      900

atgtacagtt ttgtggccaa agaaattgac tatgcaaact actttcaaac gctaatagaa      960

gtgcaagctg aataccacag gaagtccctg acactattgc aggctgtatt gcctcagatc     1020

aaagcacaac aggaggcctg ggtagagaag ccttccttcg ggaagccgct ggaggagcac     1080

ctcaccatca gcggccggga gatcgccttc cccatcgagg cgtgtgtgac catgctgctt     1140

gagtgtggga tgcaggagga gggactcttc cgagtagccc cctctgcctc caaactgaag     1200

aagctgaaag cggccctgga ctgctgcgtg gtggatgtgc aggagtactc ggcagacccc     1260

cacgcaattg caggagcttt gaaatcttac ctccgagagt tgccagaacc tcttatgacc     1320

tttgaactct atgatgagtg gatccaggct tccaatgtcc aggagcaaga caagaagctt     1380

caggctctat ggaatgcttg tgaaaagttg cccaaggcca atcacaacaa catccgatac     1440

ttgataaaat ttttatccaa gctgtcagaa tatcaagatg taaacaagat gactcccagt     1500

aatatggcaa ttgttttagg acccaacctc ctatggccac aagcagaagg gaacattaca     1560

gagatgatga ccacagtgtc gctgcaaatt gttgggatca ttgaacctat catccagcat     1620

gcagactggt tcttccctgg ggagatagag ttcaacatta ctggcaatta tgggagtcca     1680

gtacacgtga accataatgc caactacagc tcaatgccct ccccagacat ggaccctgct     1740

gaccggcgcc agcccgagca ggcccgccgg cccctcagcg tcgccacgga taatatgatg     1800

ctggagtttt acaaaaagga tggcatgggt gtgagggtca tggacacaaa ctgggtggct     1860

cgaagaggct cctcggccgg tcggaaagtg tcctgcgccc cgccctccat gcagcctccc     1920

gccccgcccg ccgagctggc tgcgcccctg ccttcgccgc tgccggagca gcccctggac     1980

agccccgcgg cccccgcgct ctctccatcc ggcctgggcc tccagcctgg gcccgagcgc     2040

accagcacaa caaaaagcaa ggaactttct ccaggctctg cacagaaagg aagtccaggc     2100

tccagccagg gcacagcctg tgcagggact caaccagggg ctcaacctgg agctcagccg     2160

ggcgccagcc ccagccccag ccagccgcct gcagaccaga gtcctcacac cctccggaaa     2220

gtttcaaaga agctggcacc gattccaccc aaggtcccct ttggccagcc gggggctatg     2280

gcagaccagt ccgctggcca gccgtcccca gtcagcctgt cccccacccc gcccagcacc     2340

ccgtcaccct atggactgag ctaccctcag gggtactcct tggcctcggg ccagctctcc     2400

ccagctgcag ctcctcccct ggcctctcct tctgtcttta caagcacttt gagcaaatcg     2460

cggcccactc ctaagccgcg acagagacct actctgccgc ctcctcagcc tcccacagta     2520

aacctctcgg cctctagtcc acagtccacg gaggccccca tgctagatgg catgtcccct     2580

ggggaaagca tgtctacaga tcttgtccac tttgatattc cctcgatcca catagagctc     2640

gggtcgacgc tccgcctgag tcccctggag cacatgcggc gacactcagt aactgacaag     2700

agggactcgg aggaggagtc tgagagcacc gccctctgac atgacaccgc ccatcctgcc     2760

tcgcgtgtac atacatcacg ggccctagga acgccgccag gagcagcgtc catgagcttg     2820

ccaagtgttc tctgctggct ctttcctgcc actgccaaca cgaggttgga atttggcaga     2880

aaattgtgat ctccagtccg tgtggtgatg ctggtggtgc aggttttgtt tgttcctttc     2940

gggtggtgac ttcggccttt tgtttgacct ttgccttttg actttgtgcc tcttttgatc     3000

cactttcagc ctccatgcca gaaaacaccc acctctccat ccaaggctgg tcaggaacgt     3060

cctttgcagg gtcggggtgg tgcgggagag gctcactttg cctggttaga cccaagggct     3120

gctacctttt ccttggacgg ctcatgtcag gtcttgcagg atcagtttaa tggccacaga     3180

aaggaagcag gacagcaggg cccctctcac ccacaactgg accaggtcca ggattctagc     3240

agtcctgggg cactgacctt tgccagctac ctgggggagg gcttgccact ggaaaacctt     3300

tcaggccgcc cccatcagtg ggctccaaag taaatggctg aaaacaaaaa tgtttcactt     3360

cctaacagtt ttcctttttc cactgtgtga ctgaaagctc ctatatcatt ttatatttct     3420

gaatctataa aacaaaacaa acaagcctga cagtgtctgg aggagccaaa ggtggcctcc     3480

ctgtccccaa atatattggc tatatgagag taattttacc cctctacgta cctaaaggca     3540

cccagttcac tagtctgtgg ggtcctggag cctgtctctt ctttctggag gttcaaactg     3600

aatagcaata attacgttac ccaaagcatg tggaggaaaa gtgaaaccag ccacggagac     3660

gctggcccac gggctcggcc tgcggtgtgg cctgctttgc tcaccagcgt cagccgctca     3720

tttccttctc atgaagtccc atctggtcat ggggacgagg gccgggaggg caccgggtag     3780

ccttttcaca cttggggatt aggggagtga gaaaagattt gggccatgca tgcaaagtca     3840

aagtttaaaa ttttatcctt ttcaaataga tgatataata tacctataca tgatataata     3900

tttgtatata tgaaatctct ctatatttgt ttaatttgag ccattcaatc taaaccaatg     3960

tacaggtgta caatgaaaaa tttaaatgct tagttatttt tcccaacaca gtgtaaagtc     4020

accctcctct gagagtggga tgtgcagagt tttgatgttg cagctttgct cacttcctgg     4080

caagggcagg tcatgcctca atttgtaatg ggagtctggg gtaagggtgg gggttgaaag     4140

ttgttatctt taaatacatg tacaaatcgt tgtcaaaagt aacgttatta aaatagattt     4200

attatccctg a                                                          4211


<210> 1198
<211> 1842
<212> DNA
<213> Homo sapiens

<400> 1198
cccgtggacg ccgccgaaga agcatcgtta aagtctctct tcaccctgcc gtcatgtcta       60

agtcagagtc tcctaaagag cccgaacagc tgaggaagct cttcattgga gggttgagct      120

ttgaaacaac tgatgagagc ctgaggagcc attttgagca atggggaacg ctcacggact      180

gtgtggtaat gagagatcca aacaccaagc gctccagggg ctttgggttt gtcacatatg      240

ccactgtgga ggaggtggat gcagctatga atgcaaggcc acacaaggtg gatggaagag      300

ttgtggaacc aaagagagct gtctccagag aagattctca aagaccaggt gcccacttaa      360

ctgtgaaaaa gatatttgtt ggtggcatta aagaagacac tgaagaacat cacctaagag      420

attattttga acagtatgga aaaattgaag tgattgaaat catgactgac cgaggcagtg      480

gcaagaaaag gggctttgcc tttgtaacct ttgacgacca tgactccgtg gataagattg      540

tcattcagaa ataccatact gtgaatggcc acaactgtga agttagaaaa gccctgtcaa      600

agcaagagat ggctagtgct tcatccagcc aaagaggtcg aagtggttct ggaaactttg      660

gtggtggtcg tggaggtggt ttcggtggga atgacaactt cggtcgtgga ggaaacttca      720

gtggtcgtgg tggctttggt ggcagccgtg gtggtggtgg atatggtggc agtggggatg      780

gctataatgg atttggtaat gatggtggtt atggaggagg cggccctggt tactctggag      840

gaagcagagg ctatggaagt ggtggacagg gttatggaaa ccagggcagt ggctatggcg      900

ggagtggcag ctatgacagc tataacaacg gaggcggagg cggctttggc ggtggtagtg      960

gaagcaattt tggaggtggt ggaagctaca atgattttgg gaattacaac aatcagtctt     1020

caaattttgg acccatgaag ggaggaaatt ttggaggcag aagctctggc ccctatggcg     1080

gtggaggcca atactttgca aaaccacgaa accaaggtgg ctatggcggt tccagcagca     1140

gcagtagcta tggcagtggc agaagatttt aattaggaaa caaagcttag caggagagga     1200

gagccagaga agtgacaggg aagctacagg ttacaacaga tttgtgaact cagccaagca     1260

cagtggtggc agggcctagc tgctacaaag aagacatgtt ttagacaaat actcatgtgt     1320

atgggcaaaa aactcgagga ctgtatttgt gactaattgt ataacaggtt attttagttt     1380

ctgttctgtg gaaagtgtaa agcattccaa caaagggttt taatgtagat tttttttttt     1440

gcaccccatg ctgttgattg ctaaatgtaa cagtctgatc gtgacgctga ataaatgtct     1500

tttttttaat gtgctgtgta aagttagtct actcttaagc catcttggta aatttcccca     1560

acagtgtgaa gttagaattc cttcagggtg atgccaggtt ctatttggaa tttatataca     1620

acctgcttgg gtggagaagc cattgtcttc ggaaaccttg gtgtagttga actgatagtt     1680

actgttgtga cctgaagttc accattaaaa gggattaccc aagcaaaatc atggaatggt     1740

tataaaagtg attgttggca catcctatgc aatatatcta aattgaataa tggtaccaga     1800

taaaattata gatgggaatg aagcttgtgt atccattatc at                        1842


<210> 1199
<211> 3516
<212> DNA
<213> Homo sapiens

<400> 1199
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc aggtggagtt ttgctcttgt cgcccaggct ggagtgcagt ggcgtgatct      300

cggctcactg caacctccac ctcccaggtt caagcgattt tcccacttca gcctcccgat      360

aagctgagat tacagagttt attaaccact taacctctca gaactgaaca aagacaacat      420

tgttcctgga acgccctctt tttaaaaaag aaagcataac ccctactgta gaactaaatg      480

cactgtgcat gaaacttgga aaaaaaccaa tgtataagcc tgttgaccct tactctcgga      540

tgcagtccac ctataactac aacatgagag gaggtgctta tcccccgagg tacttttacc      600

catttccagt tccaccttta ctttatcaag tggaactttc tgtgggagga cagcaattta      660

atggcaaagg aaagacaaga caggctgcga aacacgatgc tgctgccaaa gcgttgagga      720

tcctgcagaa tgagcccctg ccagagaggc tggaggtgaa tggaagagaa tccgaagaag      780

aaaatctcaa taaatctgaa ataagtcaag tgtttgagat tgcacttaaa cggaacttgc      840

ctgtgaattt cgaggtggcc cgggagagtg gcccacccca catgaagaac tttgtgacca      900

aggtttcggt tggggagttt gtgggggaag gtgaagggaa aagcaagaag atttcaaaga      960

aaaatgccgc catagctgtt cttgaggagc tgaagaagtt accgcccctg cctgcagttg     1020

aacgagtaaa gcctagaatc aaaaagaaaa caaaacccat agtcaagcca cagacaagcc     1080

cagaatatgg ccaggggatc aatccgatta gccgactggc ccagatccag caggcaaaaa     1140

aggagaagga gccagagtac acgctcctca cagagcgagg cctcccgcgc cgcagggagt     1200

ttgtgatgca ggtgaaggtt ggaaaccaca ctgcagaagg aacgggcacc aacaagaagg     1260

tggccaagcg caatgcagcc gagaacatgc tggagatcct tggtttcaaa gtcccgcagg     1320

cgcagcccac caaacccgca ctcaagtcag aggagaagac acccataaag aaaccagggg     1380

atggaagaaa agtaaccttt tttgaacctg gctctgggga tgaaaatggg actagtaata     1440

aagaggatga gttcaggatg ccttatctaa gtcatcagca gctgcctgct ggaattcttc     1500

ccatggtgcc cgaggtcgcc caggctgtag gagttagtca aggacatcac accaaagatt     1560

ttaccagggc agctccgaat cctgccaagg ccacggtaac tgccatgata gcccgagagt     1620

tgttgtatgg gggcacctcg cccacagccg agaccatttt aaagaataac atctcttcag     1680

gccacgtacc ccatggacct ctcacgagac cctctgagca actggactat ctttccagag     1740

tccagggatt ccaggttgaa tacaaagact tccccaaaaa caacaagaac gaatttgtat     1800

ctcttatcaa ttgctcctct cagccacctc tgatcagcca tggtatcggc aaggatgtgg     1860

agtcctgcca tgatatggct gcgctgaaca tcttaaagtt gctgtctgag ttggaccaac     1920

aaagtacaga gatgccaaga acaggaaacg gaccaatgtc tgtgtgtggg aggtgctgaa     1980

ccttttctgg ccatgaacca ttataaaatc ccaacatata tactgaaaat actgaaactg     2040

ctttgaaaat ttggaatttc tgatacctcc agtgggccga gagacacggt gggtaaagga     2100

tgtgggcagc agcagggaag acaacagaaa cacaaggagg cggctgtggc cgggctggac     2160

tgtgctgggg tttgttgtga tggccactcg gtgacctggc ggtccctacg caatagcagc     2220

tgcctgtggg gaagaagggc tgcccagcca gctggttctc ccgggacacc agcagatcca     2280

caccctgggc acctccgtgt ttggtctttt ttttcccctg tgtgaaagaa gaaacggcac     2340

gaccccttct caagctggct cactcagaca cattgggaca aaccctggac agccatgcca     2400

gagagaggcc tttgaccggc cccagagcta aaagcaccag agaaaatcaa atgcttccta     2460

ctcagcgtga cccaactttt ctagtgtgcc acggccccac cacctcctgc agtacccaca     2520

ccatcaccac tgctttctct tccaacagtg atctgtattc ttagtttcat tattttcttt     2580

tgattgatat gacactatat aaaattttca tttgagaatt tctcaattgt atctagttaa     2640

atagcacagt ttggaaactt gtctgagact gactttatca ataatctaac cgacaaagat     2700

catatccatg tgtatgtggt tagacatttt tatttcattg actaacccag gacagtttca     2760

gtgatgcaaa ttgtgtgccc tctggttcag ctgaaacagt cctggacttt caaaaacctt     2820

gaataagtct cccacagttg tataaattgg acaatttagg aattttaaac tttagatgat     2880

catttggttc catttttatt tcatttttat ttttgttaat gcaaacagga cttaaatgaa     2940

ctttgatctc tgttttaaag attattaaaa aacattgtgt atctatacat atggctcttg     3000

aggacttagc tttcactaca ctacaggata tgatctccat gtagtccata taaacctgca     3060

gagtgatttt ccagagtgct cgatactgtt aattacatct ccattagggc tgaaaagaat     3120

gacctacgtt tctgtataca gctgtgttgc ttttgatgtt gtgttactgt acacagaagt     3180

gtgtgcactg aggctctgcg tgtggtccgt atggaaagcc tggtagccct gcgagttaag     3240

tactgcttcc attcattgtt tacgctggaa tttttctccc catggaatgt aagtaaaact     3300

taagtgtttg tcatcaataa atggtaatac taaatttttt tgttaattta ttctcaaatg     3360

ccactactgc taggttggtc ccctcccaac ttgcccctat ccttttttta tttttaagaa     3420

aaaaactttg taatgcttgt gattccatct gggcaaaagt ctgaagatct gaaataactt     3480

tatatcaaac cattgatcaa taaacagcta ctaatg                               3516


<210> 1200
<211> 8259
<212> DNA
<213> Homo sapiens

<400> 1200
tcccaaagtg ctgggattac aggcgcgagt ggccgctggg gttcttaact tgggtctttg       60

aatcgcctta agaagtgtct ctgaatctgg gaattgcaag caacgtttct gtgaggacct      120

tcacacagtt catccactct tcgaagagta tggaccgaaa aaggcataga gcattcactg      180

cacgtagaga aaatcagcaa cccctgctcc ccaccctcag cctgaggtgc ctacctccac      240

gtggggtcag gaggcggaag cgaaaccaga agaaaaaacc ctgagatcta taaggcagtt      300

caggtcccta gtgacatgag ctaaagagaa cttggacgcc aggactgtag cagacagagt      360

ccggcttcgg ggttcgcatc agtcgcacgg aaggtggaaa tagcccccaa gttgtaaccc      420

gccgcggtct tccctcaaca gcgcaggcgc caggactgct aggacgccgc gcacctcccg      480

cgatgccccg ccccggcgcg aggcaagacg ggaaagtcaa gatggacgcg tccatttgaa      540

cgtctcgcac gccttcctgc cattagcact cgagcccgct gctgttgccc gttcttcctc      600

cagaataggg gagggagagg gaatgagaag ctgctgcggc ccaagagtca ctgtgaagga      660

ccccgccgct gccctcgggc ctcctcggcc cctgcgcctc cggggagcag ccggggctcg      720

ccgcgcctga cgcgtcccga gttatacaga aataatgttg atatttggaa cccatgtcga      780

acttctatga agaaaggaca acgatgattg cagcaaggga tttgcaggaa tttgttcctt      840

ttggtcgaga ccactgcaag caccacccta atgctttgaa ccttcaactt cgccagctgc      900

agccagcttc tgaattatgg tcttctgatg gtgctgctgg cttggtggga tcccttcagg      960

aggttacaat ccacgagaaa cagaaggaaa gctggcagtt aaggaaagga gtaagtgaaa     1020

ttggagaaga tgtggactat gatgaggaac tctatgttgc tggaaatatg gtgatatgga     1080

gcaaaggaag taaaagccag gcattggcag tttataaagc atttacagtt gacagtcctg     1140

ttcagcaggc attgtggtgt gacttcatta tatcacagga taagtctgaa aaggcctaca     1200

gtagcaatga agtagaaaaa tgcatatgta tattgcaaag ctcatgtatt aacatgcata     1260

gcatagaagg aaaggattac atagcttcat taccatttca ggttgcaaat gtttggccca     1320

ctaaatatgg attgctgttt gaacgaagcg cttcttcaca tgaagtacct ccaggttcac     1380

ccagagaacc tttacctact atgttcagca tgctgcaccc actagatgaa ataactccac     1440

ttgtttgtaa atctggaagt ctttttggtt catcacgggt gcaatatgtt gtagatcatg     1500

caatgaaaat tgttttcctc aatactgacc cctctattgt aatgacttat gatgctgttc     1560

aaaatgtgca ttctgtgtgg actctccgga gagtcaaatc agaggaagag aatgttgttt     1620

taaagttctc tgaacagggg ggaaccccac agaatgtggc cactagcagc tccctcacag     1680

cacatctcag aagcctctcc aaaggagatt cccctgtgac ttcacctttc cagaattact     1740

cctccattca cagccagagt cgctcaacct catcacccag tctacattct cgctcacctt     1800

ctatttccaa catggcagct ctaagtcgtg ctcattctcc tgcgttagga gtgcactctt     1860

tttcaggggt gcaaaggttc aacatttcaa gccataatca gtctccaaag agacatagta     1920

tttctcattc tccaaatagt aattctaatg gctcctttct tgcaccagaa acggagccaa     1980

ttgttcctga actgtgtatt gaccatttgt ggacagaaac gattactaat ataagagaga     2040

aaaattcaca agcctcaaaa gtgtttatta catctgacct atgtgggcaa aagttcctgt     2100

gctttttagt agagtcccag ctccagttac gctgtgtaaa gtttcaagag agtaatgata     2160

aaacccagct catctttggt tcagtgacca acataccagc aaaggatgca gcaccagtgg     2220

agaaaataga caccatgctg gtcttggaag gcagtggaaa cctggtgcta tacacaggag     2280

tggttcgggt gggaaaggtt tttattcctg gactgccagc tccctctctg acgatgtcca     2340

acacaatgcc tcggcccagt actccactag atggcgttag tactccaaag cctcttagta     2400

aactccttgg atcattggac gaggttgttc tgttgtcccc agttccagaa ctgagggatt     2460

cttcaaaact tcatgattct ctctataatg aggattgtac tttccaacag cttggaactt     2520

acattcattc tatcagagat cctgtccata acagagtcac cctggaactg agtaatggct     2580

ccatggttag gatcactatt cctgaaattg ccacctctga gttagtacaa acgtgtttgc     2640

aagcaattaa gtttatcctg ccaaaagaaa tagcagttca gatgcttgtc aagtggtaca     2700

atgtccacag tgctccagga ggacccagtt atcactcaga gtggaattta tttgtgactt     2760

gtctcatgaa catgatgggt tataacacag accgcttagc atggactaga aattttgact     2820

ttgaaggatc actttctcct gtcattgcgc ccaaaaaagc aaggccttcc gagactggat     2880

ctgatgatga ctgggaatat ttactaaatt cagactacca ccagaatgtt gagtctcatc     2940

ttttgaacag atctttatgt ctgagtcctt cagaagcttc acagatgaag gatgaggatt     3000

tttcacagaa tctcagtctg gattcttcta cacttctctt tactcacata cctgcaattt     3060

ttttcgttct tcaccttgtg tatgaggagc ttaagttgaa tactctaatg ggagaaggaa     3120

tttgttcact tgttgaactt ctcgttcagt tggcaaggga cttaaaattg gggccttatg     3180

tagatcatta ctatagagac tacccaacgc ttgtcagaac tactggacaa gtgtgcacaa     3240

ttgatccagg tcaaacagga tttatgcatc atccatcatt ttttacgtct gagccaccaa     3300

gtatttatca gtgggtgagt tcttgtctga agggtgaagg aatgccacct tatccttacc     3360

tccctggaat ctgtgaaaga agcagacttg tagtcttgag tattgcactg tacatacttg     3420

gtgatgagag cttggtttct gatgaatcct cacagtattt aaccagaata actatagccc     3480

cccagaagtt gcaagtagaa caagaggaaa acaggtttag tttcaggcat tctacatctg     3540

tttctagtct agctgaaaga ttggttgtct ggatgactaa tgtaggattc actttaagag     3600

atttggaaac tcttcccttt ggaattgctc ttcccatcag agatgcaatt tatcactgtc     3660

gtgagcagcc tgcctcagac tggccagaag ctgtctgtct cttgattgga cgtcaggatc     3720

tttccaagca ggcctgcgaa ggaaacttac ccaaagggaa gtctgtgctc tcatcagatg     3780

ttccttcagg aacagaaact gaggaggaag atgacggcat gaatgacatg aatcacgagg     3840

tcatgtcatt aatatggagt gaagatttaa gggtgcagga tgtgcgaagg cttcttcaga     3900

gtgcgcatcc tgtccgtgtc aacgtagtgc agtacccaga gctcagtgac cacgagttca     3960

tcgaggaaaa ggaaaacaga ttgctccaat tgtgtcagcg aactatggct cttcctgtag     4020

gacgaggaat gtttaccttg ttttcgtacc atcctgttcc aacagagcca ttgcctattc     4080

ctaaattgaa tctgactggg cgtgcccctc ctcggaacac aacagtagac cttaatagtg     4140

gaaacatcga tgtgcctccc aacatgacaa gctgggccag ctttcataat ggtgtggctg     4200

ctggcctgaa gatagctcct gcctcccaga tcgactcagc ttggattgtt tacaataagc     4260

ccaagcatgc tgagttggcc aatgagtatg ctggctttct catggctctg ggtttgaatg     4320

ggcaccttac caagctggcg actctcaata tccatgacta cttgaccaag ggccatgaaa     4380

tgacaagcat tggactgcta cttggtgttt ctgctgcaaa actaggcacc atggatatgt     4440

ctattactcg gcttcttagc attcacattc ctgctctctt acccccaacg tccacagagc     4500

tggatgttcc tcacaatgtc caagtggctg cagtggttgg cattggcctt gtatatcaag     4560

ggacagctca cagacatact gcagaagtcc tgttggctga gataggacgg cctcctggtc     4620

ctgaaatgga atactgcact gacagagagt catactcctt agctgctggc ttggccctgg     4680

gcatggtctg cttggggcat ggcagcaatt tgataggtat gtctgatctc aatgtgcctg     4740

agcagctcta tcagtacatg gttggaggac ataggcgctt tcaaacagga atgcataggg     4800

agaaacataa atcaccaagt tatcaaatca aagaaggaga taccataaat gtggatgtga     4860

cttgtccagg tgctactcta gctttggcta tgatctactt aaaaaccaat aacagatcta     4920

ttgcagattg gctccgagcc cctgacacca tgtatttgtt ggactttgtg aagccagaat     4980

ttctcttgct taggacactt gctcgatgcc tgattttgtg ggatgatatt ttaccaaatt     5040

ccaagtgggt tgacagcaat gttcctcaaa ttataagaga aaatagtatc tctctcagtg     5100

aaatcgaatt gccgtgctca gaggatttga atttggaaac tttgtcccaa gcacatgtct     5160

acataattgc aggagcctgc ttgtctctgg gttttcgatt tgctggctca gaaaacttat     5220

cagcatttaa ctgtttgcat aaatttgcca aagattttat gacttatttg tccgcaccta     5280

atgcttctgt tacaggtcct cataacctag aaacttgtct gagcgtggtg ctgctgtctc     5340

tcgccatggt catggctggc tcaggaaacc taaaggtttt gcagctttgt cgcttcttac     5400

acatgaaaac gggtggtgaa atgaactatg gttttcactt agcccaccac atggcccttg     5460

gacttctatt tttgggagga ggaaggtact ctttgagcac atcaaattct tccattgccg     5520

ctcttctctg tgccctttat ccgcacttcc cagctcacag cactgacaac cggtatcatc     5580

tccaggctct ccggcacctc tatgtgctgg ccgcggagcc caggcttcta gtgcctgtgg     5640

atgtggacac aaacacgccc tgctatgccc tcttagaagt tacctacaag ggcactcagt     5700

ggtatgaaca aaccaaagaa gaattgatgg ctcctaccct tcttccagaa ctccatcttt     5760

taaagcagat taaagtaaaa ggcccaagat actgggaact gctcatagat ttaagcaaag     5820

gaacacaaca cttgaagtcc atcctttcca aggatggggt tttatatgtt aaactccggg     5880

cgggtcagct ctcctacaaa gaagatccaa tgggatggca aagtttgttg gctcagactg     5940

ttgctaacag gaactctgaa gcccgggctt tcaagccaga aacaatctca gcattcactt     6000

ctgatccagc acttctgtca tttgctgaat atttctgcaa gccaactgtg aacatgggtc     6060

agaaacagga aattctggat ctcttttctt cagtactcta tgaatgtgtt acccaggaga     6120

ccccagagat gttgcctgca tacatcgcaa tggatcaggc tataagaaga cttgggagaa     6180

gagaaatgtc tgagacttct gaactttggc agataaagtt ggtgttagag tttttcagct     6240

cccgaagcca tcaggagcgg ctgcagaacc accctaagcg ggggctcttt atgaactcgg     6300

aattcctccc tgttgtgaag tgcaccattg ataataccct ggaccagtgg ctacaagtcg     6360

ggggtgatat gtgtgtgcac gcctacctca gcgggcagcc cttggaggaa tcacagctga     6420

gcatgctggc ctgcttcctc gtctaccact ctgtgccagc tccacagcac ctgccaccta     6480

taggactaga agggagcaca agctttgctg aactgctctt caaatttaag cagctaaaaa     6540

tgccagtgcg agctttgctg agattggctc ctttgcttct tggaaatcca cagccaatgg     6600

tgatgtgacc gtgtctggcg gtgaacctac cctgaaacgt gacttctgca caacaaacgt     6660

gaccaaacat caaagctaaa gcaatgttta taaagtttta tggtataact agggggaaat     6720

gagctgcaca aacctcaatg tattttaaat ctgttgctgt catcattaac ggtatatgac     6780

atataaaagc aagttaaaat ttacttttgt aaataaagtt tttggtttgt ttccaaaact     6840

cttgatgatt gctttagttt tggacttaga gaatagagca ggggttgctg gagtgaatat     6900

tgatttttaa agtctttgaa ctgtggtggt ataggtgaag tgactatgcc caaaaatgcc     6960

aagttttaaa agaagctatg tcataaagtt ttactttctg tggcaaaaga gcgctttagc     7020

atttcctcag atgtcacagt tgtcctgtct aaaataagtt tgtacttctg gtgacaatgc     7080

cagacactct tatgatgtga tcaccttaaa caggagaagg agatttttgc cctcagttgc     7140

tcaacatgaa gtactgtgga ctgaattgtg tcctcccaga attatatatt gaggccctaa     7200

tccctgtgtg actgtattag gcaatagggc atataggaga ttactaaggt taagtgaggt     7260

catcataagg gtggggcctt aattcagtag aattggtggc ctcctaagca gaggaagaga     7320

gatttttctt tctctctctg ccatgtgaag acagtgagga gtcggccgtc tgcaagccaa     7380

gaagagccct tatcaggaac agacttggct agcaccttca tcgtggacct ccagcctcca     7440

gaattgcaag aaaatacatt tccgtcgttg aaaccaccca gtctgtggta ttttgttatg     7500

gcagcccagg cagactaata cgtgaagcct gctctaaata gataaaataa gaaattacta     7560

cagagggctc tttagaaatt gtatttaaaa acaagacaat ccatatttac ctaagattta     7620

cagaatgtat gtctataaaa ggagggattt ctggactaga tgatgatgaa aaatgttcat     7680

ataaaggcac ctccagcttc gagttgccaa cacaggagga agaatgctcc ctgctgttca     7740

gatgctgata tgtgtcctgt gcttcctgga tggccagtgg gatcataagc tggtagaagc     7800

aagaccttca tccactgact tcatatttct tccacatcct gaactgtggt gtttgacttt     7860

aaaaataaat taaagcaaat agaaatgttt ccattgagat tttggcaaaa acccacatga     7920

catttgcgtc tgcagagtag acttggaagg catgcacctg gaggccaagt ggtattctct     7980

ggactctctg tccttgcatt tgcgtggctg ccccgaggac tcgcttcttc ctggatgtga     8040

agcagaggca cgatggggct gactgagagg ctgaaatgtg cttctcttca cagttacata     8100

gttttcttct aattaaaaat aaattttaag tggtagatta tgaaaattcc atttgaatca     8160

agattttaaa aattcaatat caaaccagtt gttactgtct tcactctccg ttgtttacga     8220

ttgtgtgctt ttcctgaata aagaatgact ggagagaca                            8259


<210> 1201
<211> 1524
<212> DNA
<213> Homo sapiens

<400> 1201
gagctggagt gaagggagct agtggtaaag ggagctggtg gaggggtggc ggcaggggta       60

gcagtcacca ttatgctcaa agcggtgatc ctgattggag gccctcaaaa gggaactcgc      120

ttcagacctt tgtcttttga ggtgcccaaa ccattgtttc ctgtggcagg ggtccctatg      180

atccaacacc atattgaagc ctgtgcccag gtccctggaa tgcaggagat tctgctcatt      240

ggcttctacc aacctgatga gcccctcacc cagttcctag aagccgccca gcaggagttt      300

aaccttccag tcaggtacct gcaggaattt gcccccctag gcacaggggg tggtctttac      360

cattttcgag accagatcct ggctgggagc cccgaggcat tcttcgtgct caatgctgat      420

gtctgctccg acttcccctt gagtgctatg ttggaagccc accgacgcca gcgtcaccct      480

ttcttactcc ttggcactac ggctaacagg acgcaatccc tcaactacgg ctgcatcgtt      540

gagaatccac agacacacga ggtattgcac tatgtggaga aacccagcac atttatcagt      600

gacatcatca actgcggcat ctacctcttt tctcctgaag ccttgaagcc tcttcgggat      660

gtcttccagc gtaatcagca ggatgggcaa ttggaggact caccaggctt gtggccaggg      720

gcaggtacca tccgcctaga gcaggatgtg ttttcagccc tggcagggca gggccagata      780

tacgtgcatc tcactgatgg tatctggagt cagatcaagt ccgcaggttc agccctctac      840

gcctcccgcc tctacctgag ccgataccag gacactcacc cagaacggct ggccaagcac      900

accccagggg gcccatggat ccgagggaat gtgtacatcc acccgaccgc caaggtggcc      960

ccctcggctg tgctgggccc caacgtctcc atcgggaagg gggtgaccgt gggtgagggt     1020

gtgcggctcc gggagagcat cgtcctccat ggagccactt tgcaggagca cacgtgtgtt     1080

ctgcatagca tcgtgggctg ggggagcacc gtgggacgct gggcccgcgt ggagggtacc     1140

cccagtgacc ctaaccccaa cgatccccga gcccgcatgg acagtgagag cctcttcaag     1200

gacgggaagc tgctgcctgc tatcaccatc ctgggctgcc gagtccggat ccctgccgag     1260

gtgctcatcc tgaactcgat tgttctgcca cacaaggagc tgagccgaag cttcaccaac     1320

cagatcatcc tctgagtagg gctgccagaa ggcccccagc tcctacccac tccccttgag     1380

gctgctgcct gcttggccag cctctgtcca gaaaggacca gagaaagcca ggctggatcg     1440

tcacatgccg gggagcaatg tggatggcct ggggactcct gggttttctc cctcccgact     1500

ccctaataaa ccccgtgaac cttg                                            1524


<210> 1202
<211> 1364
<212> DNA
<213> Homo sapiens

<400> 1202
aatcccgtgc ggcgcgcaca ggcaggaggt tgcagttggg cgctcagcag ctgtggcagc       60

cggttgaggt ctggcagtag cgttgggctg aagcagcgga gttcgccatg cgcgagtgta      120

tctctatcca cgtggggcag gcgggtgtcc agatcggcaa tgcctgctgg gaactgtact      180

gccttgaaca tggaattcag cccgatggcc aaatgccaag tgataaaacc attggtggcg      240

gggacgactc cttcaacacg ttcttcagtg agactggagc tggcaagcac gtgcccagag      300

cagtgtttgt ggacctggag cccactgtgg tcgatgaagt gcgcacaggg acctacaggc      360

agctcttcca cccggagcag ctgatcaccg ggaaggaaga tgcagccaat aattacgcca      420

ggggccatta caccatcggc aaggagattg ttgacctagt cctggaccgg atccgcaaac      480

tggcggatct gtgcacagga ctgcagggct tcctcatctt ccacagcttt gggggcggca      540

ctggctctgg gttcgcatct ctgctcatgg agcggctctc agtggattac ggcaagaagt      600

ccaagctaga gtttgccatt tacccagccc cccaggtctc cacagccgtg gtggagccct      660

acaactccat cctgaccacc cacacgaccc tggaacattc tgactgtgcc ttcatggtcg      720

acaatgaagc catctatgac atatgtcggc gcaacctgga cattgaacgt cccacgtaca      780

ccaacctcaa tcgcctgatt gggcagatcg tgtcctccat cacagcctcc ctgcgatttg      840

atggggccct gaatgtggac ttgacggaat tccagaccaa cctagtgccg tacccccgca      900

tccacttccc cctggccacc tatgccccag tcatctcagc tgagaaggcc taccacgagc      960

agctgtctgt ggccgagatc accaatgcct gcttcgagcc agccaatcaa atggtcaagt     1020

gtgaccctcg ccacggcaag tacatggcct gctgcatgtt gtacaggggg gacgtggtcc     1080

ccaaagacgt caacgcggcc atcgccacca tcaagaccaa gcgcaccatc cagtttgtgg     1140

attggtgccc gactggattt aaggtgggca ttaactacca gccccccaca gtggtccccg     1200

ggggagacct ggccaaggtg cagcgggccg tgtgcatgct gagcaacacc acggccattg     1260

cggaggcctg ggcccgcctg gacctggcag ctctagagaa ggattatgaa gaggtgggcg     1320

tggattccgt ggaagctgag gctgaagaag gcgaagaata ctga                      1364


<210> 1203
<211> 1562
<212> DNA
<213> Homo sapiens

<400> 1203
gggaaacgcc tgctgctctt gcccttgccc acgggccccc agccccagcc cctctcctgt       60

ggcccaccac ccctgctttg gtgccatgca gctgccaccc ttcgacatgt ggaaggacta      120

cttcaacctg agccaggtgg tgtgggcgct gatcgcaagt cggggtcaaa ggctggagac      180

ccaagagatt gaggagccaa gtcccgggcc tccgctgggg caggatcagg ggctgggggc      240

gccaggggcc aacgggggcc tggggaccct gtgcaacttc tgcaagcaca acggggagtc      300

ccgccacgtc tactcctcac accagctgaa gacaccggat ggcgtggtgg tgtgtcccat      360

cctgaggcac tacgtgtgtc ccgtgtgcgg ggccaccggt gaccaggccc atacgctcaa      420

gtactgcccg cttaacggtg gccagcagtc cctctaccgc cgcagcgggc gcaactcggc      480

cggacgcagg gtcaagcgct gagcatcgtg agatgctcac cacccgcacc cctgaccctc      540

ctggtccatc ccacccaagt ccctaaactc tctcttccag tcacccagcc ctttggaatt      600

tctggccccc agaactccac cctggctgga tcctgaaaca gtggaggctg ctgggagcca      660

ggccagcccc gcccccttgg acctgtcagc cctcggagct ctggcctgtg ggcgttggcc      720

tgagggtcct tggtgccgcg ggaacccttc ctgcacggcc ctgtagcgcc ctctgggccc      780

cggttcatgg atcttttgtc ctcgtggggc ctgctggtga ctggagccct gccccttcga      840

cttctctgtt ccttgtggag ttcttggatt tttgaacctc caggattcca cggtgctgtc      900

ccaagccagc ccttaggaga tactgaacaa ggctggctga gaagtgccta ctcaagaact      960

tcaagatggg atgtcgactt aagaccagcc ttctccatct tcagcctcct gcagaaccac     1020

ggtgtcatcg tggaccacgc ctgttcattc cttccctgac ctcagtaccc atccgtcagg     1080

agcggagtag gactctggag agcaccgtat cactggaggg caccgtgtct tcgcaggctc     1140

acctgtggat ggagagccgt ggggtgagct gacacctttc aatgccccct ggttgttctt     1200

ccccttgttc agcccattgc acccggtacc tgcccccatc cccaaatcac cgatgggtcc     1260

tttcccccag cgagaagcat atctctcgac cacctcccgt ccgacccccc aaatcgtgat     1320

agttgactaa aggacatttt tttttcctcc tgtgtttttc aacctccaac gttcaagtca     1380

aggaaccgcc gataagaagg gggtttgagt acccggatgg gaatggcaat ggcctagctt     1440

ttattttagg ggcaaagaga agaagggccc ccgtcagatt ttaagttgtt cagtttttgg     1500

cacagggtcg ggaccctgag tattgagctc tggtgaataa aaaggttttc tagtcgtctt     1560

tg                                                                    1562


<210> 1204
<211> 1407
<212> DNA
<213> Homo sapiens

<400> 1204
atgcgcgcct caccctgcat ctcccagccc gcagccagct ggcatcctag accctctgcc       60

ctgcgaccaa cagccgggag cggaccagac accagaactc ccggaacggt tgaagacggt      120

tccgctccct gtcccgcctt tcgcagccca gcagtttcgc cctgcggaga ggagccttgc      180

tgtttccaaa tctctcctgc tgaagagaca ttggagctag ggcggctagt ttcacctggt      240

aattgtgaca ccctgtctcc tcgagctgca ggcttttatg cttgtcatgt tcgaagtttg      300

ataccttgca gatcaacaaa gggccggtgg cctctcactg cctccgcggc agggttgtca      360

agtttttcag gttaagtact gcacgactac tcgcttctga aactgataga cactgcctca      420

gctccgtgca gggcagacgc acaagagcag aatctccgtg ggacatctct ctggagcatc      480

aatattactg cagtatttgg aagaaacaaa tttaaataag ttctaaggtg aagaatggaa      540

catttaagac aagtctggaa agtcatctgc ctttaataac tgtcgtttgt ccttaacgtc      600

agactttctc caagaccaaa actctaagaa cttatttcca ttcttacaaa tagtaaaaat      660

gataaatcat atcaagtcaa ttgaaagtcc tgcctgctgc tttcctaaat tgcaatatgg      720

ccttggtatg gttttatttg tacttttgtg ggggattcgt ggatctttag attaaaaaaa      780

aaaaaatagg tttttgaaca atttttgcaa gtttgcagct gttagttatt gatttatttt      840

tccaacccat ctaattcttc tgtctctctc ctctcctcag gctcaataat tccatgggtc      900

tctaaggctg tgtttatttt ctttaaattt tgttgattta cttttatact ccatttgatt      960

ttttctatct ctcacctttt ctcagactca gtcatcccac aggtctgtaa ggctctgttc     1020

attttcttta aacttctttt ttttttcctc tcctcagatt ggataaatta tattgctatg     1080

tctctgtttc tgaactatag aaaagctcaa aattattatt tttatttctc attttttata     1140

tggctatttt ttctctgctg atgtttcaca tctattcatt tatgagaata ttttcctttg     1200

ccctcatgag cgtgtttata atagctgcct tcaaattctt gtctgccgtt tacatcttgg     1260

acatcttgga gatggctact gcctgctttt tatcttgtgt atttattaca ttttcacgtg     1320

tcttcacgca tcccttgaat tggaaattgt gccctggaga ctgtatacaa gactggatta     1380

aaaagactgg attctgtttt gtccctg                                         1407


<210> 1205
<211> 2495
<212> DNA
<213> Homo sapiens

<400> 1205
gcgtcggtcc aggcggcgcg cacggtatgg cggcggcggc ggcggcggcg gcgcgcgcct       60

gagaagaggg gacgccagcc cggtcaggcc tcggcgcggc ctacacgctc cgctcgctcg      120

ctcgctcccg cctcccgccc cgcgcccggc catggcggag ccgtcgtccg cccgacgccc      180

ggtgcctctc atcgagtcgg agctgtactt ccttatcgcc cggtacctat cggcgggccc      240

gtgtcggaga gcggcccagg tgctggtgca ggagctggag cagtaccagt tgttgccgaa      300

gagattggac tgggagggca acgagcacaa caggagctac gaggagttgg tcttgtccaa      360

taagcatgtg gctcctgatc atcttttgca aatctgccag cgcatcggtc ctatgttgga      420

taaagaaatt ccacccagta tttcaagagt cacttcttta cttggtgcag gaaggcagtc      480

tttgctacgt acagcaaaag gtaccttaat ttgaagaagt gttctgcttt gtattaatag      540

cctaataatt attataattg tgaagtaatg taagcattgt ggaagaaagg tgataatgta      600

actataaatc atgctgtgga ctataaaatt ctctgcattt agcatagaac attgaatttt      660

attacataag tgtttaatgg gtccttctgc attaaaaagt tgataaagat atagatgtta      720

agctaaaaag cttgaattta ttctgagatg ttgtttgagg ttttatcaat gtgagttctt      780

aattttccat tttgtagctc actcataact tcattgaatg taattgtatg tgtctaataa      840

actctttaaa tgctagaggt atttcatttg atatttagct tctgaaagcc ctttgttata      900

aagggaagtg attttctaaa tttggtagca gcttgaaaac aagcaccaca aatgtaaaac      960

tgcatggttc tttttttact aatttaattt ttttgccaag ttatgtgcta gcaaaatgtt     1020

tgaaattgct attctttttc tgttagcttg gtatatatga cttagactaa gtatatgtat     1080

gtgatataat atatgtgtac atgtggctaa actgctaatg ggcaaagatt gttggttctt     1140

ctgatgctga gtatacatca agttcatccc atgattattt tttattacga gctattgctg     1200

atgtgatgct actcttagct gcaccaccag tataaagctt aactgagaaa gaacacccct     1260

ccctcttagt tccgtgccag actggtttgt tagctttagt tgtttcttag tgctctagcc     1320

atgtcaccct gtggcactaa tcaggacact gtttatattc ttcctcttct gtgtccctat     1380

tcactttgta attattctat tttagctggt tatatggtag ttaattggta gcctgttttc     1440

ctttgttttc tttacttgtg tcaagctcca tgtcgttgtt ttgtgatgag cagtgattta     1500

gaactggcca gaccttagaa gagtcttcag caagctgccc tagggtaggg gcgtattctc     1560

tgtttgtttt gtactggtac cccaggagga tgccttgtaa ctgctctttg gtcatgatag     1620

tggtaatgaa tccattcatg taaaatgcaa tatgtctgtt agtttggggc acccgaggct     1680

cagtagaggt ttagtatgat gccttccctt tcttctttga gttatgaaga aactaatttc     1740

tggcacagtg tgactgcttc aaacctatgt tctgctgcta tctcctatag aggagggcag     1800

actttttttt cttagtgcat ttgctggtag gtcaaggagg gatggacttt gaattagtgt     1860

tcagagtcac agatcctacg tatgtgctct tcagtagagg attttctgtg atcctacaat     1920

gaagggaaag ctatataatt tattggtact tcctaaagat agagactaaa gtcatggtag     1980

tattggccaa attaatttta aaactgaaca agtcatgaat tttcatataa atcaaagaac     2040

tttttcctta taaaagcttc catttttgaa aagttggatc agttgtaaga cctttcatct     2100

ttagtattgt atgatataat tctacattga aaaataaaca cttggcatta aatgggactt     2160

ggagtcaaaa gatctggttt tatggtccat cttttaccaa tcatttgctg tggatctctt     2220

taaaggtcct ggaacctttg agcctcagtt acctcacttg taaattggca aaaataccta     2280

cctcacaggg ttgttgtgag gattcaatga gctaatgtat gttgaaagca ctttgtgaat     2340

tgtaaagtgc tacacaaatg ttagttgttg ttgctgctgt atctgagatg tcttaatttt     2400

ctttttcttc agaaatagtc taataaacct ccagggcttt tctgttaaag tatactagtt     2460

ggtaaaatgt tgaataaaca gtttattaca atata                                2495


<210> 1206
<211> 3332
<212> DNA
<213> Homo sapiens

<400> 1206
atgatcccaa agagcctggt ccaggcagcg gaaacccaga ggggtctctg cgagccagga       60

gggaaaggaa gagaggggag aagtggagga aaaggggaga cacgccccag aggagttgga      120

acgcaggagg gaaaggggac catacccggt agcccgaggg aaaaacgagg cgagagggga      180

gaaggcgacc ccgcgctgct acccgcggaa gatttatggc gcctcccggg ttccaaggac      240

aggctgcgtt cgtcgctgct gccaccgccg ggaccccctt cttctgactc cgggcccgga      300

cccccctcct ctcactcagg gaaaaccgcg cagggaccca ggaccctcaa ctgggccaga      360

aagcaaagtg caaggaccag cagcaacttg tgtgcctgga gccttgcaat ggctacgaag      420

atggctgaga ttccttctag cccatatgag ccgggacagc gaggcatgaa ggatactcag      480

agaggtgatg cccctcaaag aggaagccca gagccccgaa tcctgcagtt ggcccgagtg      540

ggaaacgtat atctgaagga ggaaagctca aggagtgggc gactggaagc taagaagtgg      600

atcccaacaa agttccttga gaacctctct gtcccacacg ttgacctcgg tggaaaccag      660

ctttggagcg gcggcatgga ggctctcacc actcagctgg ggccggggcg cgagggcagt      720

tcctcgccca actccaagca ggagctgcag ccgtactcgg gctccagcgc tctcaaaccc      780

aaccaggtgg gcgagacgtc gctgtacggg gtgcccattg tgtcgctggt catcgacggc      840

caggagcgcc tatgcctggc gcagatctcc aacaccctcc tcaagaacta cagctataat      900

gagatccaca accgccgcgt ggccctgggc atcacgtgcg tgcagtgcac gccggtacag      960

ctggagattc tgcgtcgggc cggggccatg cccatctcgt cgcgccgctg cggcatgatc     1020

actaagcgag aggccgaacg cctgtgcaag tcgttcctgg gcgagcacaa accacccaag     1080

ctgcccgaga acttcgcctt cgatgtggtg cacgagtgcg cgtggggctc gcgtggtagc     1140

ttcatccctg cgcgttacaa cagctctcgt gccaagtgca tcaagtgcgg ctactgcagc     1200

atgtacttct cgcccaacaa gttcatcttc cactcgcacc gaacacccga cgccaagtac     1260

acgcagcccg atgccgccaa cttcaactcc tggcgtcgtc acctcaaact cagtgacaag     1320

tcggccacag acgaactgag ccatgcttgg gaggaccgcg gacttggcct ggcgactgga     1380

gctagtggcc cggcgggccc aggagggccc ggtggcggcg ccggcgtacg aagctacccg     1440

gtgatcccgg tgcccagcaa aggctttggg ctcctgcaaa agctgccccc accacttttc     1500

ccccatcctt acggcttccc tacggccttc ggcctatgcc ccaaaaagga cgacccggtt     1560

ttaggcgcgg gcgagccaaa gggcggctcc tacgtgtcgg ccttccggcc ggtggtcaag     1620

gacaccgaga gcatcgctaa gctctacggg agcgcccggg aggcgtacgg cgcggggcct     1680

gctcgggggc cgggacccgg cgctgggagc ggcggctacg tgagcccgga ctttctgagc     1740

gagggcagct ccagctacaa ttccgcctcg cccgacgtgg acaccgcgga cgagcccgag     1800

gtggacgtgg aatccaaccg cttccccgac gacgaggacg cccaagagga gaccgagccc     1860

agcgcaccca gcgcaggggg cggcccagac gctggccggc ccgcatttgg ggacttggca     1920

gccgaagact tggtgcggag acctgagagg agcccgccaa gcggcggcgg cggctacgag     1980

ctgcgagagc cttgcgggcc cctaggaggc cccgcgccgg ccaaggtgtt cgcgcccgag     2040

agggatgagc acgtgaagag cgcggcggtg gcgctggggc ccgcggcctc ctacgtctgc     2100

acccccgagg cccacgagcc agataaggaa gacaatcact cgcccgccga tgatttggaa     2160

acgaggaaat cctatccaga ccaaaggagt atctcccagc caagtcctgc aaatacagac     2220

agaggcgaag atgggcttac cttggatgtc acaggaactc atttggtgga gaaagatatc     2280

gagaacctgg ccagagagga attgcaaaaa ctgctcctgg aacaaatgga gctccgcaag     2340

aagctggaac gggaatttca gagtctcaaa gataattttc aggatcaaat gaagagggaa     2400

ttggcttatc gagaagaaat ggtgcaacag ctgcaaattg tcagagatac cctgtgtaac     2460

gaactcgacc aggagcggaa ggcgcgctat gccatccagc agaaattgaa agaagcccac     2520

gacgccctgc accatttctc ctgcaagatg ctgacgcccc gccactgcac tggcaactgc     2580

tccttcaagc caccgctgtt gccctagggc cggcctggcc gcacccctgc gccctcaagc     2640

catgctgctc cttgtaaata cccgctgctg cggtggccct gagcgaggaa caagccattc     2700

ggacccgacc gatgtaaata cagccgcccg tccgcccgcc ttcctcccgg gctccccggc     2760

cttgcccgcc ccctcccggg cgtccctgtc cagggccccg gcttggtttc caagtgtaaa     2820

taccgcctcg cgcctcaaat ccccctaccc cgtgtgaact ctagggcatc ggacctcaag     2880

gggttaactg gacagacggg gggcgggagg ggagagcgcc ccctcccatt gtatagcctt     2940

gaacccgatt gtgaatacaa tgtagcaact tcgctggcgc ctgccccgca ctccccgtcc     3000

cgtccacttc tgaaactcct gttcctaatg acaaagtggc tatgtgcaat ggatataaat     3060

gtactgtgag tctctcggtt cagtattagg ttcactttaa tttatttatg ctgtaagtta     3120

tttttgcttc cttctcctgg acccacttcc agtcccgttt tgcattcccc tttggatttt     3180

gctttggcta ttttttgttg taacctcttg atgtaacagc actttaaaag ggcgacaact     3240

gactcacgag atggcaacca cctggagcct gtttggggag accaccctgt acccgtgact     3300

ttcgttttta ataataataa taataataat aa                                   3332


<210> 1207
<211> 5512
<212> DNA
<213> Homo sapiens

<400> 1207
gcaggctgcg gacccagttg cgagaggcct attatctgct gatccaggcc atgcacgacc       60

tgccccctga ctcgggcgcg cggcggggcg gcaggggctt ggcggatcac agcttccccg      120

cgggagcccg ggctccgggc cagccgcctt cccgcggcgc cgcgtaccgc cgagcctgcc      180

cccgggacgg ggagcgggga ggcggcggac gccctcggca gcaggtgtcc ccgccccggt      240

cgcctcagag ggagccgcgg ggaggccagc tgcggactcc tcggatgcgg ccgtcctgca      300

gcagaagcct cgagagcctc cgggtgggtg ccaagccgcc tcccttccag cggtggccga      360

gcgacagctg gatcaggtgc ggcgcgcacc gggactggga cgagcccccg ccacgtggag      420

gcaggatgga cggctggagt ggggaccgcg cccgggcggc tgcacccacc ggcctccagc      480

ctccaggctg caaggaccac ggctgctcct cgggaagccc tttcagggat ccagcggggt      540

cctctgtgat acgcagtggc aaaggagacc gccaggaagg cccctccttc ctcaggccgc      600

cggcagtgac agtcaagaag ctgcagaagt ggatgtacaa agggcgtctg ctgtccctgg      660

gaatgaaggg tcgtgcccgt gggacggctc ccaaagtcac aggaacgcag gcagcctccc      720

caaatgtggg cgctttgaaa gtgcgtgaaa accgtgtcct gtcggtgcct ccagaccaaa      780

gaattacgct gacagattta tttgaaaatg cctatgggtc ttcaatgaag ggaagagaac      840

ttgaagagct gaaggataat attgaattca gaggtcataa gccacttaac agcatcactg      900

tttcaaagaa acgcaattgg ctatatcaga gtactctgag gcctcttaat ctggaagaag      960

aaaataagaa atgccaagat agaagtcatt tatccatctc acctgtgtct ctacctaaac     1020

atcagctatc acagtctttc ctcaaatcat ctaaagagta ctgtacatat gtggtatgta     1080

acgctacaaa ctcttcatta tcgaaaaact gtgctttaga ttttaatgag gaaaatgatg     1140

cagatgatga aggagaaata tggtacaatc ccattcctga ggatgatgac cttggtatat     1200

caagtgcctt gagttttggt gaggccgact ctgctgttct gaagctccct gctgtcaatt     1260

tgagcatgtt gtctggcagt gacctgatga aagcagagcg gcatactgaa gactcactgt     1320

gctcttccga acatgcaggt gatattcaga ccacacggtc aaatggaatg aatcctatac     1380

atcctgccca ttccacagaa tttgtgcagc agtacaagca aaagctagga cacaagacac     1440

aagaaggtat aatggtggag gacagtccca tgttgaaatc tccttttgca ggttctggga     1500

tcctggctgc tacaaatagt actgaattgg gaattatgga accatcttct ccaaatccta     1560

gccctgtgaa aaaaggcagt tcaattaatt ggtcattgcc agataaaata aaatctccac     1620

gaactgtgag gaaactttcc atgaaaatga aaaagttgcc agaatttagc cgaaagctaa     1680

gcgttaaggg aacattgaat tatataaaca gtccagataa tactccttct ttgtctaaat     1740

ataactgccg agaagttcat catactgata ttctgccctc tgggaacaca accaccgctg     1800

ctaagaggaa tgttataagc cgataccatc ttgataccag tgtatcctcc cagcagagct     1860

accagaagaa aaactctatg agttctaagt attcctgcaa aggtggttac cttagtgatg     1920

gagactcacc tgaacttaca actaaagcta gcaaacatgg atctgaaaac aaatttggaa     1980

aaggaaaaga aataatttca aatagttgta gcaagaatga aatagacatt gatgctttta     2040

ggcattatag cttttctgat caacctaagt gttcacagta catatctggg ctcatgagtg     2100

tacatttcta tggtgctgag gatttaaaac cacctcggat agattcaaaa gacgtctttt     2160

gtgcaattca ggtagattca gtaaacaaag caagaacagc tttgctcaca tgccgaacaa     2220

catttttaga catggatcac actttcaaca tagaaattga aaatgcacaa catttgaaac     2280

tagtagtatt cagttgggaa cccactccaa gaaaaaatcg agtttgttgt catggaactg     2340

ttgttcttcc caccttattt agagtgacaa agactcatca gttggctgtc aaacttgaac     2400

ctagaggtct tatttatgtg aaagtgactc ttatggaaca gtgggagaat tctcttcatg     2460

gactagatat aaaccaagaa ccaataatat ttggagttga tattcaaaaa gttgtagaga     2520

aagaaaatat aggactgatg gtgccccttc tgatacagaa atgtattatg gaaattgaaa     2580

agagaggctg tcaggtagta ggcctgtatc gattatgtgg ttcggcagca gtcaagaaag     2640

aactgcgaga ggcttttgag agagatagca aagctgttgg tctgtgtgaa aaccagtacc     2700

cagatataaa tgtaataaca ggtgttctta aggattattt aagagaactc ccttctcctc     2760

tgataacaaa gcagctttat gaggctgtat tagatgcaat ggcaaaaagt cctttgaaaa     2820

tgtcatcaaa tggttgtgag aatgacccag gtgactctaa gtacactgtt gacctgctgg     2880

attgtctgcc agagattgag aaggcaaccc taaagatgtt gttggatcat ttgaaattgg     2940

tggcttccta tcatgaagtg aataagatga cgtgccagaa tttggctgtg tgctttggac     3000

cagtattatt aagtcagagg caagagcctt ccacccataa caacagagtc tttactgatt     3060

cagaagaact tgcaagtgct ttggatttta aaaaacacat tgaagttctt cattacttac     3120

tccaactctg gccagtgcag cgtttaactg tcaaaaaatc aacagacaat ttattcccag     3180

agcagaagtc ttctctgaat tatctgaggc agaagaaaga acgacctcat atgttaaatt     3240

tgagtggtac tgattcatca ggagtactta ggccaaggca aaaccgatta gacagtccac     3300

ttagcaatcg ttatgcagga gactggagca gctgtgggga aaactacttt ttaaatacaa     3360

aagaaaattt aaatgatgtg gattatgatg atgtcccttc agaagataga aaaatcggag     3420

aaaattatag caaaatggat gggccagaag taatgattga acagccaatt cccatgtcca     3480

aagagtgtac atttcagaca tatttgacaa tgcagacagt tgagtctaca gtggatcgaa     3540

aaaacaatct caaagatcta caagaaagta ttgatacttt gattggaaat ctggaacgtg     3600

agctcaacaa aaacaagctt aatatgagtt tttgagattg agggtttttt tttgtaatgt     3660

cttaaagttt caaatctgtt tttgttttat tttcttatac cacccacagc gatgttttca     3720

tttttttact cttgaaatct ttaattaatt tttaataagt ttatctgatt caattaaaaa     3780

cactattcat taatacaatt tttacttatc tcactagaaa acttttctgg ggatcaataa     3840

aacttggact tcttgggata ttttactaaa tcttgccaac tctatggaga taactttcaa     3900

atgcacttaa gaaggttcac ataagttatt agcccctcaa ggtttttctg ctttatggga     3960

accactcttc tgtagctgag acagatgtcc ttttttttgt tgttttttga gacagagtct     4020

cactctgtcg cccaggctgg agtgcactgg tgcgatctca ggtcactgca acctccacct     4080

ccctggttca agtgattctc ctgccacagc ctcccgagta gctgtgatga cggggcccac     4140

caccatgccc agctaattat tgtattttta gtaaagatgg ggtttcacca tgttggccag     4200

gctggtctcg aactcctgat ctcagatgat ccgcccacct tggcctccca aagtgctggg     4260

attacaggcg tgagccactg cgcctggcct ctagatgttc ttttagagga acatcacagc     4320

tgctcagtct gatttgcagt actggtcctg gtacactgca acatcctttg gtcaaatttt     4380

atttgtaatg caaatgctgc tataagaaaa tctttttata aataaaagtg aaattataca     4440

agtattaatg ttttctgtat taacagtaat tatttaagct tataaaaatt aaatattttt     4500

ataatcctga aactgtatat atttataaat gcatatatgt atagatatca ggatggggga     4560

ggggttattg tagaatcaca tgtattttta aagtatatat gtcatgaggc caaaattatt     4620

atcttaaagt atttttttca gggaaagaac atttaaatta aaggaggaat tacataaaaa     4680

cacttgaaca ataatactct agaagcatct gaatagaaat aatagacttt ctttccttta     4740

ttcacagaaa gtcacaatgt cccctgggaa aagtcatctt ttaaatttga aatcctctaa     4800

ctccttaagg gattaagtac ccagatttct gcactggtga cttagattta ataaatctgc     4860

tcctgttcta tgcattttta tattctgctt tgttttaatt atttatttgt agtagtacat     4920

ttataacatt gactttataa ttacccccat ttgtttctaa atagtcttgc cagcatatta     4980

catgttactg atttttaaaa attaacttat tttggctaag tatatataca atgttataga     5040

atcacagtaa tgtttgaaaa tgtaaattta gaaggctttt gtattaaatc aaaatgtatt     5100

tttttaactt ttatatctac agaatatgta attttaaaat tataaataga ctttaagtta     5160

ccaactttta agacatggca gccattgaaa aactggcttc ctgatgtttt tctaaatatt     5220

aaagtactta aaatatttct atgcaataaa tattgataaa cagacattat ttaatttgaa     5280

aacccattgt taaaaaagat aaatattttt atatgaaatt ttcatttttt aaaactttgt     5340

gttaacaatt cagaagaata ccaagagaac atatatattg agtaaacagt caaaggaaag     5400

tactcttgaa tgttttatag gaaagctgtc tcagtttcct tccttttgtt gctatatcat     5460

gtatgaattg aataaattgc tctagaaatg taaaaatttt attaaaatat ta             5512


<210> 1208
<211> 1353
<212> DNA
<213> Homo sapiens

<400> 1208
atggatccgg ggaatgagaa ttcagccaca gaggctgccg cgatcataga cctagatccc       60

gacttcgaac cccagagccg tccccgctcc tgcacctggc cccttccccg accagagatc      120

gctaaccagc cgtccgagcc gcccgaggtg gagccagatc tgggggaaaa ggccattgaa      180

agcgccccgg agaagcgact gacacttgcc cagatctacg agtggatggt ccgtactgta      240

ccctacttca aggacaaggg tgacagcaac agctcagcag gatggaagaa ctcgatccgc      300

cacaacctgt ccctgcacag caagttcatc aaggttcaca acgaggccac cggcaaaagc      360

tcttggtgga tgctgaaccc tgagggaggc aagagcggca aagccccccg ccgccgggcc      420

gcctccatgg atagcagcag caagctgctc cggggccgca gtaaagcccc caagaagaaa      480

ccatctgtgc tgccagctcc acccgaaggt gccactccaa cgagccctgt cggccacttt      540

gccaagtggt caggcagccc ttgctctcga aaccgtgaag aagccgatat gtggaccacc      600

ttccgtccac gaagcagttc aaatgccagc agtgtcagca cccggctgtc ccccttgagg      660

ccagagtctg aggtgctggc ggaggaaata ccagcttcag tcagcagtta tgcagggggt      720

gtccctccca ccctcaatga aggtctagag ctgttagatg ggctcaatct cacctcttcc      780

cattccctgc tatctcggag tggtctctct ggcttctctt tgcagcatcc tggggttacc      840

ggccccttac acacctacag cagctccctt ttcagcccag cagaggggcc cctgtcagca      900

ggagaagggt gcttctccag ctcccaggct ctggaggccc tgctcacctc tgatacgcca      960

ccaccccctg ctgacgtcct catgacccag gtagatccca ttctgtccca ggctccgact     1020

cttctgttgc tgggggggct tccttcctcc agtaagctgg ccacgggcgt cggcctgtgt     1080

cccaagcccc tagaggctcc aggccccagc agtctggttc ccaccctttc tatgatagca     1140

ccacctccag tcatggcaag tgcccccatc cccaaggctc tggggactcc tgtgctcaca     1200

ccccctactg aagctgcaag ccaagacaga atgcctcagg atctagatct tgatatgtat     1260

atggagaacc tggagtgtga catggataac atcatcagtg acctcatgga tgagggcgag     1320

ggactggact tcaactttga gccagatccc tga                                  1353


<210> 1209
<211> 1712
<212> DNA
<213> Homo sapiens

<400> 1209
tgggcggggt tatataagcc agcggcgggc ggaaggcggg gcgtgggggt ctgtggctgc       60

tgggctggcg gggcgcaggc cgcgggaccc gagcccgggg aagcgagaga gcggaggcgc      120

cgaggatccg attcactccc tggggagacc tatgggccga agccgtgtaa atgcgtttta      180

agcagaggcc tcggctccgc aactgccact cctcctcggg gtgttgcaca agtttcgagg      240

tcaccggcga ccccccctag cagcgcgcct ggctctggcc cccgcgaagg aggacggagt      300

ttggagcttg cggcccccac ccaccgcgtg gcgtccccag gcacgcctag aattctagca      360

cctcaggatc agtccagccc ccatttacaa ttggggaaac tgcggctccg aaagggtcag      420

agggtacccg aggtcaagca gtagagagcg gactcgaact taagctcttg ctcttaggct      480

gagacgcctt gatgtggcca ccggctaccc tctagtgtgt tgcatacttt ctaaggcggc      540

ggctgcagca gcggctccat ccagcccgtc agctcctcct gcaaggcatg gctggctacc      600

tgagtgaatc ggactttgtg atggtggagg agggcttcag tacccgagac ctgctgaagg      660

aactcactct gggggcctca caggccacca cggacgaggt agctgccttc ttcgtggctg      720

acctgggtgc catagtgagg aagcactttt gctttctgaa gtgcctgcca cgagtccggc      780

ccttttatgc tgtcaagtgc aacagcagcc caggtgtgct gaaggttctg gcccagctgg      840

ggctgggctt tagctgtgcc aacaaggcag agatggagtt ggtccagcat attggaatcc      900

ctgccagtaa gatcatctgc gccaacccct gtaagcaaat tgcacagatc aaatatgctg      960

ccaagcatgg gatccagctg ctgagctttg acaatgagat ggagctggca aaggtggtaa     1020

agagccaccc cagtgccaag tttgtccagc agaggggcac tgcgtgtctc atcaggatgg     1080

ttctgtgcat tgctaccgat gactcccact ccctgagctg cctgagccta aagtttggag     1140

tgtcactgaa atcctgcaga cacctgcttg aaaatgcgaa gaagcaccat gtggaggtgg     1200

tgggtgtgag ttttcacatt ggcagtggct gtcctgaccc tcaggcctat gctcagtcca     1260

tcgcagacgc ccggctcgtg tttgaaatgg gcaccgagct gggtcacaag atgcacgttc     1320

tggaccttgg tggtggcttc cctggcacag aaggggccaa agtgagattt gaagagattg     1380

cttccgtgat caactcagcc ttggacctgt acttcccaga gggctgtggc gtggacatct     1440

ttgctgagct ggggcgctac tacgtgacct cggccttcac tgtggcagtc agcatcattg     1500

ccaagaagga ggttctgcta gaccagcctg gcagggagga ggaaaatggt tccacctcca     1560

agaccatcgt gtaccacctt gatgagggcg tgtatgggat cttcaactca gtcctgtttg     1620

acaacatctg ccctaccccc atcctgcaga agtctaagaa ccactcaccc tgctacatgt     1680

ctctagagtc cattcatttc attgccgtgt ag                                   1712


<210> 1210
<211> 2989
<212> DNA
<213> Homo sapiens

<400> 1210
tcagtctttc gcggcccggg agctcagcag agctaccagc tgccctgttg gcttcgctgg       60

tcggatcgtc ctcctggccc cgccaaacag gcggggggag cggccccgac tgtggggcca      120

tggcagtagt ctcctcgttc gccgccgccg ctagcctagc tgagtcgccg gcttctgcgc      180

taggggctcc caccgcctcc gcaggctaag gagccgctgc caccaacgag ctgtgagggt      240

tactatgctc cctctttgcc gccgtctcct cctcttgccc gcgcaggcac ccctctggct      300

gctcagtcct gcctcagtgt caaaccagaa gagaagtaaa attcaacaaa aatttatgtg      360

tggagttcct tcttaaaaga agaaaaaagt gattatttag actatggatc ggagcaaacg      420

gaattcaatt gcaggatttc ctccacgtgt ggagcgtctt gaagagtttg aaggaggtgg      480

tggaggagaa ggaaatgtga gccaggtggg aagagtttgg ccatcttcgt atcgagctct      540

tataagtgcc ttttccagac tgacgcgttt ggatgatttc acctgtgaaa aaatagggtc      600

tggcttcttt tctgaagtgt tcaaggtacg acaccgagct tctggtcagg tgatggctct      660

taagatgaac acattgagca gtaaccgggc aaacatgctg aaagaagtac agctcatgaa      720

tagactctcc catcccaaca tccttaggtt catgggtgta tgtgttcatc aaggacaatt      780

gcatgcactt acagagtata tcaactccgg gaacctggaa cagttgctag acagtaacct      840

gcatttgcct tggactgtga gggtaaaact ggcctatgac atagcagtgg gcctcagcta      900

ccttcacttc aaaggcattt ttcatcggga cctcacatct aagaactgcc tgataaagag      960

ggatgagaat ggttactctg cagtggtagc tgactttggc ctggctgaga agatccccga     1020

tgtcagcatg gggagtgaga agctggccgt ggtgggttcc ccattctgga tggcacctga     1080

ggttctccga gatgagccct ataatgaaaa ggcagatgtg ttctcttatg gtatcatcct     1140

ctgcgagatc atcgcccgca tccaggccga tccggactat cttccccgca cagagatgga     1200

tcccaaactg cgcccatctt ttgtggagat tgggaagacc ctggaggaaa ttctgagccg     1260

cctacaggaa gaagagcagg agagggatag gaagctgcag cccacagcca ggggactctt     1320

ggagaaagca cctggggtga agcgactaag ctcactggat gacaagatcc cccacaagtc     1380

accatgccca agacgtacca tctggctgtc tcgaagccag tcagatatct tttcccgtaa     1440

gcccccacgt acagtgagtg tcttggaccc atactaccgg ccacgagatg gtgctgcccg     1500

cacccccaaa gtcaaccctt ttagtgctcg ccaggacctc atggggggca agatcaagtt     1560

ttttgacctg cccagcaagt ctgtcatctc tctggtattt gacctggatg caccagggcc     1620

cggaactatg cccctggctg actggcagga gcccctggcc ccacctattc gccggtggcg     1680

ttccttgcct ggttcgcctg agttcttgca tcaagaggct tgtccatttg tgggccggga     1740

agaatcgcta tctgatgggc ccccaccacg cctaagtagt ctcaagtaca gagttaaaga     1800

gatcccacca ttccgggcat ctgccctacc agctgctcaa gcccatgagg ctatggactg     1860

ctccattctc caggaagaaa atggttttgg gtccaggccc caggggacca gtccatgccc     1920

tgcgggtgct tctgaggaga tggaggtaga agaaaggcca gcaggctcaa ctccagccac     1980

cttctccacc tcaggcatag gcctgcaaac ccagggaaag caggatgggt gagggggttt     2040

agtccctgcc tcaccttggg gatggacctt cagctgaaac catatggccc cctaggtgca     2100

cagccttgat tcttccctgg agcctacaga gcaggcaggc taggccaagc caggctcaac     2160

ttctgggctc ccagtgccca ttggctgtgt atgacgggag gcagcagtga gaggccttcc     2220

tagttagggc caacagctga taccaagcct ctgaaatcca gcaaggaggt ctgcctccca     2280

ccagaccctc tccagtgtac ttccccagat aggaccagag gatgtctagt tctaggctga     2340

gctggcaggc agctattacc ccggttcttt ccccacccca ggtctgtctc ttgccttttc     2400

ttggggcata taagctactg agtggaacat ggagctgatc aagaggccgt aatggtcatg     2460

gctgtttccc agacctgaat attggggtgc ttcttgccag tattctaaga catttgagta     2520

attgctgttt gcacttactg catggtcaga ccacgtcact acatttctat gcaaggggac     2580

agcaaggcag cgtggtggtc atggctctta gctaacctat tcaaagacct tttcctgttg     2640

attaatctat tttcatattt ataaaggagt cttaatgttc tgccccataa gactttcaac     2700

cttgtggttg ggagtggggc tggttttgta ggccctaggg cctgcttcta tgtatttatc     2760

aacatgtgat acattcaatt ggttaaatgg tttatacagg gactgatttg cttcccttcc     2820

tgccatggct ggagctttgg gaacagtctg tccttacaga gctgcaataa gaaataacca     2880

aagatgaagc tggtcaaata ttttcataac ttgcttctgt tgattttttt ttttgtaaaa     2940

ctttcccaag acattttcag acttaaaaat aaagtcagtg ttacaggtg                 2989


<210> 1211
<211> 814
<212> DNA
<213> Homo sapiens

<400> 1211
aacagggctt cgtcttcttt gcagagccat gggcagcagg aagaaggaaa ttgccctgca       60

ggtcaacatc agcacccaag agctttggga ggaaatgctc agttccaaag gactaactgt      120

tgttgatgtc tatcaaggct ggtgtggccc ctgcaaacct gtggtgagcc tcttccagaa      180

gatgaggatc gaggtcggcc tggaccttct gcactttgca ttaattaaag atgaggctct      240

ttctgatgaa gatgaatgtg tttcccatgg aaagaataat ggtgaagatg aggacatggt      300

ttcatcagag aggacctgta ccttggccat cattaaacca gatgcagtgg cccatggaaa      360

gactgatgag attatcatga agattcagga agctgggttt gaaattctaa caaatgaaga      420

gagaaccatg acagaggcag aagtgcgact tttctaccaa cacaaagctg gagaggaggc      480

atttgagaag ctggtacatc acatgtgcag tggaccaagc cacctcctga tcctcaccag      540

gactgagggc ttcgaggacg tggtcactac ctggcgaacc gtcatgggcc cccgtgaccc      600

caatgtggcc aggagggagc agccagaaag tctccgagct cagtacggca cagaaatgcc      660

cttcaatgcc gtccatggaa gccgggacag agaagatgct gacagagaac tggcattgct      720

cttccccagt ttgaaatttt cagacaaaga tacagaagcc cctcagggtg agtccagtac      780

acagccaagg ttgaagatca ctgacctaga ctaa                                  814


<210> 1212
<211> 3328
<212> DNA
<213> Homo sapiens

<400> 1212
agtgaagcct gcccacttgt gaagacggag actccccgct ccccggatga gaagcaagtg       60

cgtcagaggg aagcagccca actggttgct gagttgtgga aaataagctg ggggagaaaa      120

aacacttctt ttaaaaatca ggttagggat gaatgtgcag ggcgtggttc ctgtgcaatt      180

atctgctctg ctggctgcgg ggctccctgc ttctcccggg ccgctgtgtc aggcttgtgc      240

ctgttgctcc tcccctccac tcctccccct cctcctcctc cgcctcctcc ccctcctcct      300

cctcacaggt gtgtctctag tcctcgtggt tgcctgcccc actccctgcc gagacgcctg      360

ccagaaaggt cacctatcct gaaccccagc aagcctgaaa cagctcagcc aagcaccctg      420

cgatggaagc tgcagatgcc tccaggagca acgggtcgag cccagaagcc agggatgccc      480

ggagcccgtc gggccccagt ggcagcctgg agaatggcac caaggctgac ggcaaggatg      540

ccaagaccac caacgggcac ggcggggagg cagctgaggg caagagcctg ggcagcgccc      600

tgaagccagg ggaaggtagg agcgccctgt tcgcgggcaa tgagtggcgg cgacccatca      660

tccagtttgt cgagtccggg gacgacaaga actccaacta cttcagcatg gactctatgg      720

aaggcaagag gtcgccgtac gcagggctcc agctgggggc tgccaagaag ccacccgtta      780

cctttgccga aaagggcgag ctgcgcaagt ccattttctc ggagtcccgg aagcccacgg      840

tgtccatcat ggagcccggg gagacccggc ggaacagcta cccccgggcc gacacgggcc      900

ttttttcacg gtccaagtcc ggctccgagg aggtgctgtg cgactcctgc atcggcaaca      960

agcagaaggc ggtcaagtcc tgcctggtgt gccaggcctc cttctgcgag ctgcatctca     1020

agccccacct ggagggcgcc gccttccgag accaccagct gctcgagccc atccgggact     1080

ttgaggcccg caagtgtccc gtgcatggca agacgatgga gctcttctgc cagaccgacc     1140

agacctgcat ctgctacctt tgcatgttcc aggagcacaa gaatcatagc accgtgacag     1200

tggaggaggc caaggccgag aaggagacgg agctgtcatt gcaaaaggag cagctgcagc     1260

tcaagatcat tgagattgag gatgaagctg agaagtggca gaaggagaag gaccgcatca     1320

agagcttcac caccaatgag aaggccatcc tggagcagaa cttccgggac ctggtgcggg     1380

acctggagaa gcaaaaggag gaagtgaggg ctgcgctgga gcagcgggag caggatgctg     1440

tggaccaagt gaaggtgatc atggatgctc tggatgagag agccaaggtg ctgcatgagg     1500

acaagcagac ccgggagcag ctgcatagca tcagcgactc tgtgttgttt ctgcaggaat     1560

ttggtgcatt gatgagcaat tactctctcc ccccacccct gcccacctat catgtcctgc     1620

tggaggggga gggcctggga cagtcactag gcaacttcaa ggacgacctg ctcaatgtat     1680

gcatgcgcca cgttgagaag atgtgcaagg cggacctgag ccgtaacttc attgagagga     1740

accacatgga gaacggtggt gaccatcgct atgtgaacaa ctacacgaac agcttcgggg     1800

gtgagtggag tgcaccggac accatgaaga gatactccat gtacctgaca cccaaaggtg     1860

gggtccggac atcataccag ccctcgtctc ctggccgctt caccaaggag accacccaga     1920

agaatttcaa caatctctat ggcaccaaag gtaactacac ctcccgggtc tgggagtact     1980

cctccagcat tcagaactct gacaatgacc tgcccgtcgt ccaaggcagc tcctccttct     2040

ccctgaaagg ctatccctcc ctcatgcgga gccaaagccc caaggcccag ccccagactt     2100

ggaaatctgg caagcagact atgctgtctc actaccggcc attctacgtc aacaaaggca     2160

acgggattgg gtccaacgaa gccccatgag ctcctggcgg aaggaacgag gcgccacacc     2220

cctgctcttc ctcctgaccc tgctgctctt gccttctaag ctactgtgct tgtctgggtg     2280

ggagggagcc tggtcctgca cctgccctct gcagccctct gccagcctct tgggggcagt     2340

tccggcctct ccgacttccc cactggccac actccattca gactcctttc ctgccttgtg     2400

acctcagatg gtcaccatca ttcctgtgct cagaggccaa cccatcacag gggtgagata     2460

ggttggggcc tgccctaacc cgccagcctc ctcctctcgg gctggatctg ggggctagca     2520

gtgagtaccc gcatggtatc agcctgcctc tcccgcccac gccctgctgt ctccaggcct     2580

atagacgttt ctctccaagg ccctatcccc caatgttgtc agcagatgcc tggacagcac     2640

agccacccat ctcccattca catggcccac ctcctgcttc ccagaggact ggccctacgt     2700

gctctctctc gtcctaccta tcaatgccca gcatggcaga acctgcagcc cttggccact     2760

gcagatggaa acctctcagt gtcttgacat caccctaccc aggcggtggg tctccaccac     2820

agccactttg agtctgtggt ccctggaggg tggcttctcc tgactggcag gatgacctta     2880

gccaagatat tcctctgttc cctctgctga gataaagaat tcccttaaca tgatataatc     2940

cacccatgca aatagctact ggcccagcta ccatttacca tttgcctaca gaatttcatt     3000

cagtctacac tttggcattc tctctggcga tggagtgtgg ctgggctgac cgcaaaaggt     3060

gccttacaca ctgcccccac cctcagccgt tgccccatca gaggctgcct cctccttctg     3120

attacccccc atgttgcata tcagggtgct caaggattgg agaggagaca aaaccaggag     3180

cagcacagtg gggacatctc ccgtctcaac agccccaggc ctatgggggc tctggaagga     3240

tgggccagct tgcaggggtt ggggagggag acatccagct tgggctttcc cctttggaat     3300

aaaccattgg tctgtcactt ctcttgta                                        3328


<210> 1213
<211> 6210
<212> DNA
<213> Homo sapiens

<400> 1213
atgaaaaaga agcagacggt gcagggcacc ttcagcaaac tcttcgggaa gaagcacacc       60

acgaccccca gcacctccct ctacgccacc aatccgccct ggatcttcac ccaggaggcc      120

ccggaggagg ggaccggggg cttcgatggc atctattatg gagacaatcg gtttaacaca      180

gtgagcgagt caggaacagc cacgctgaaa gctcggccaa gagtccggcc cctgctgacc      240

ttccttccgc tgaatgccca ggaaaaccat gggctggctg tgcccacccc ctcggttcca      300

gatgattttg cagacaaaga agtgacaggt accagctcac tagtcaatgg caacctccga      360

ctgtacagct ctgtgggtga cctgaggcct ggacaatatg gccaggatct actcatcccc      420

ccacctcccc caggcccagc cccagggccc cctcaggaca tttcagaacc tccagggggg      480

tcgccactgc catctccacc ttccacagca cccccaccac ctcccctgct gctggaaccc      540

ccacccccgc ccagcatggc cccacctcca cccccagtat tggaggccct atccccacca      600

cacactcttt cctccccatc catacccacc cctcctgact tcattccccc tgccccaccc      660

ttggcctttc tagccccccc accgcctcct gtgccagccc cagcaccccc agctccagca      720

tctcctcaca cagtggggac tcgtctcttt ccccctgggg gtgtcaccaa gtggaaatca      780

gatgtagcac tgaatggcag gcaggcagag gccaccagag ccagcccccc gagaagccct      840

gctgagccaa aggggagcgc cctgggacct aacccagagc cccatctcac cttcccccgt      900

tctttcaaag tgcctccccc aaccccagtc aggacttcgt ccatcccagt tcaggaagca      960

caagaggctc cccgaaagga agagggggcc accaagaagg ctcccagccg actcccactg     1020

cctcccagct tccacatccg ccccgcctcc caggtctacc cagacagggc ccccgagcca     1080

gactgccctg gggagctcaa ggccacagca ccagccagcc caaggcttgg ccagtcccag     1140

tcccaagcag atgaacgagc tgggactccg cctccagccc ctcccctgcc ccctcctgca     1200

ccccccctcc ctcccccagc acccccactt cccccagctg cacctccttt gccctgtgct     1260

cagaaggcag cccatccacc tgctgggttt acaaaaaccc ctaaatccag ctctcctgct     1320

ctcaaaccca aacccaaccc ccccagccca gagaacacag cgtcttcagc acctgtggac     1380

tggagggacc ccagccagat ggaaaagctg cggaacgagc tggcagccta tctctgtggc     1440

tccaggagag aggaccgatt cctcagtcac aggccaggcc caacagtggc ccctcagagc     1500

aaggagggca agaagggccc ccgcctgcct gagaaggaga ctctcctgag cctgccagca     1560

aaggacactc ccccaggtgt tcctgaaaag agtcttggcg gcagcagcct gacagagaca     1620

gaggctgccc ccagcctgac cctgccctct gtggactaca ttccccaaga ctctccaact     1680

cccagtgtgc ggcagatccg gaatgagctg gaggcccggc tctcctcagc agcagagaag     1740

gaggctaagc ccagcatagg atctctgccc cctaagcctc ggctagaagg gggaagaatt     1800

tgtgaaaacg gggctgatga tgacaaactc tccaagcctg tggccaagaa tctgccacct     1860

caatccacca ccctgctgcc aactacatca ctccagccca aggctatgtt gggaccagcc     1920

ataccaccca aggccacacc tgagccagcc ataccaccca aggctacact ttggccagcc     1980

acaccaccca aggccacact tgggccagcc acaccactca aggccacatc tgggccaacc     2040

acaccactca aggccacatc tggccctgcc atagcatcta cagccacaac tctgcccacc     2100

accacatccc aactgatggc agagaaggac tcaggcccag ctggccagcc agagaagcca     2160

gcatctcaag aagtttccac tccctcccag gcaaggggag aggggtcccc ctcagaggcc     2220

actaggctgc ccacacaggg agcccgctca tctgcagcct tcccaccaaa gacatctcct     2280

ggtggaggag aggtgccatg tctctacaag ccccactgcc accagagcag cctcagccgt     2340

gaggttgctg tggtgatgcc caccctggcc agaggagggg ctgcagggcc aggggagccc     2400

gtggaggtga aggagccccc agggctgcca gccaagcctc ctgcctcggc ccagcccact     2460

gatgaactcc tcaggcaccc ggtgactggg gaggtggtgg agcggggctc gccgatggcc     2520

ctgctcctgg cggccaggca gagggctcag aagggaaggt ctgtaggggc tgccctgggt     2580

cggtcctctc tgccaggaag tctccgtgac cacagccacc aagccgaggc cagctctgac     2640

agcatcttcc acagccaggg cacgcccaac tccttcactg tggtgcccaa gttacccaag     2700

gaggctgaga aggactcccc gctgacgacc gaaataccca ataagtgggg gccgcggctg     2760

ggaagagacg cagagggcac agagctgagc cgcaggcaca actggacaaa gccagagccc     2820

caggcccctg tggcctggga aagagtagct ccctccaacc tcccccaggg ccacccgctg     2880

cccaagtcct tctcctcccc accttctcct tcgaacaaga gggaggagga ggaggaggag     2940

ttcaacttcg aggtcatccc accgccgcca gagttcagca atgaccctga gcccccggcc     3000

ccggccctcc agtatctggg ccgccagagc tcccctcccc ggaacaacta ctcagacttg     3060

aggcagctcc cgaacgctgg ccccggggcg cccccggctc tcggcttctc gcgctttccc     3120

gcgggcgcgc gctacgccgg ggctgggggc ctggagcgct tctcgggagg gggccgctcg     3180

ctcataaaga agcgcctgta cgtcggggag ccgcaccgag gcccagggct accccacggt     3240

ggcaccggcc gcagcctgag ctctcccaac tgcttcgggc cgcagcccgg aggccccgag     3300

atgcggcgcg tgaactcggc gggtcgcgcg ccccccggag gcctgcacgc gccgaggctg     3360

tccctggagg gcgccgcccg gggcgccgcg gaggccaagc acaaagcgcc cggcagcgcc     3420

gactacggct tcgccccagc tgccggcagg tctccctaca ccaccacccg ctatggaagc     3480

cccatcaaca cgttcaccgt gaggcctggg acccgccatc ccatctccta tgtctgctca     3540

ggggcccatc ggaaagccac ctcctgagcc aggggttctc ttagctctac tccaacaaac     3600

tgtgtcttta aggatctggg cacttgtttc ttgtgggggg tgggaggtac acagcaggtg     3660

ttgggcgacc tgactcagac acagaggagt ctttgatccc caaagaccaa cgatgagaag     3720

cagtggccca ggaagaccga gagtgggctt ctgtttccca aagcgctggt gtgactgtgg     3780

actgtttaca cgtggggggt gggaggggaa ggagggtaga gagaaggaac cattaaggac     3840

ctgggcgctg agtttctgct ctctggtact atctgcttta gcaagagtta tttaaaacag     3900

ttttacaagc acggcctact gagcaggttc tgaaagcaag gggtggggca ctgactgaac     3960

tggaacccat cgagatagct gtgattgcct gtcaggccct tgcaaagggc tgaggcccag     4020

ctctgtctgg tgggtgtgca gggcaccgaa gggagatctt tagcctccat cacctgccat     4080

cccaagcaag agtggacacc tggggttcct agccgcattg aggtgggacc aggaatgtgt     4140

atgtataaca tgtggagaag gaccatgtgt ggggtgggga gtgaagctcc cacatgtgga     4200

atggaagccc tttgcattgg ccaagggcag aggtgggaga ttgatggttc atttttcctt     4260

ggccctagcc cttagctaca gggaggccta gagagaggac acttggcaag tttaggatgg     4320

gaaacaaggt taagcctggc tttgctattc agacctgtgc agccctgatt ttggggactg     4380

ggcccaagga gccatgagtc ttaggcttga cactaggggc cttacatggc caggtctcat     4440

atgggatttg gagaaggcat ttttcctaac actgatacta caagtcacca atactcttga     4500

tgccttaaga tgctagaaag ccttggagag tggaggcagc agagatggga atggaggtct     4560

gaagaagctt gctgctgttg gggaatgtgt ttgggaaagt caagagtggt aggattggtt     4620

ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccga ggccggtgga     4680

tcacttgagg tcagaagttc gagaccagcc tgcccaaatg gtgaaacccc atctctacta     4740

aaaatacgga aaaaaaaaaa aaaagagtgc taggattggg ccagttaaga gcaggggaga     4800

cctggctggg catggtggct cacacctgta attctagcac tttgggaggc tgaggcgggt     4860

ggatcatgag gtcaagagat taagaccatc ctggcctaca tggcgaaacc ctgtctctac     4920

taaaaataaa aaaatgacct gggcatggtg gtgggcgcct gtagtcccag ctactcgggg     4980

cgctgaggca ggagaatcgc tcgaacccag gaggtggagg ttgcagtgag ccgagattgc     5040

acaattgcac tccagcctgg cgacagagcg agactcgtct caaaaaaaaa aaaaaaaaaa     5100

aaaaaaggag caggggagac ctatcagtag ggtgaccacg tgtcctttgc ctgggcagtc     5160

caggtttatg cttgttttcc agtgaattag acccccttcc acttttcaaa aaagtcctgg     5220

tttagatgct gtgatcacca aacatatcag gaaacaatat tccttggtct tgcttcccta     5280

tcttcaggta ctggtgggcc aaattcctgg gaccaggtca aggtgggctg cctcagtaag     5340

aaggaaggac tggagagtgc ccatttcaga ggagcaggct ggtgggggcc agccagaaag     5400

tagttccctt tggggggaag atgttggacc tttattattt gtggtaacca gccgaggctg     5460

gttgtcagga cagcaggtga gccactttag ggaagaaagt gcaggggtgg gtggatgccc     5520

agattaccaa ggccagccac cctgatgggg tagggtctgg ttatctgtgt tcaagaagca     5580

aatcccaccc cagccccagc actagctctc tatgtatgta ttttccctgt acaatgtttt     5640

ataaaagaga tcattaattt atctgctatg ttaaggctcg aggggtgggg cgtagactct     5700

cagctgtata ttgctctggg gtgggcaggg aaggctgagt ctcacttgac ttggaagata     5760

aacaggccag tttggactgg cctccagctc cgtggctgtg tttgtctaac aaggatttgg     5820

gtaactactg gatacaagcc actgtgctta gtatggatag actgccatca gctcacccac     5880

atgactcctg ttcatggcaa gctaatagtc tgtctggtgg aagaggattg aaaaagcaca     5940

caaaaacatc ataaattaca aggagtagta agaaggaaaa aacagggaac gtgagagaat     6000

aactagcgag tggggagagg agtggattta ctttaacagg gtagtcaggg aaggcctctt     6060

gtggtggtga catactgatt taggcaaagc gtccagcacg tgcctagcgc ttagtagttg     6120

ctcagcaaat ggcatctttg ggtgatgaat acctcacatt tgtatatggc ctgtcacagt     6180

tttccataaa gctttttttt ttaaggccat                                      6210


<210> 1214
<211> 8361
<212> DNA
<213> Homo sapiens

<400> 1214
actacagacg gggtttctcc atgttggcca ggcgggtctc gaattcccga cctcaggtga       60

tcagcctgcg ttgacctccc aaagtgctgg gattacagac gtgaaccact gcgcccggcc      120

tggagattat attttaaagt tattttgaat actccctgga aaagttcttg gttcatactt      180

atacccgtaa gtcaaaagat ttgtcaaata ttcaagaaca atcaaacaat cacttaaaaa      240

tactgtataa aagtttctat ttcggcatac tttactttta cttaactaaa atttcaaata      300

aaatgtatcc acttttatga tctcaacaag atcggtcatt cctatagcgg agttgaaaac      360

tttcaactta ttcacaatta tcaaaagaat ggagcagccc ccacagagac ttccagcaat      420

gagttgtaaa atgcagtctg cattaagtag cttccttaca atcatcccga tggtaaaagt      480

gtcaaatttc gcaaacgcct ggacaaggaa gtgaaatgat catctaataa cgcagttgac      540

tcatctgtca aataagcgag tgggccaggg tccctgagct cactaccctc agattctaac      600

tccagcttca catcattagg cgtaagcagc caattgggcc gtctgggagc cgtgcatcct      660

gggagttata gtttccggct ccctccttca gattacaagc tccacagagc cgcgggagga      720

cggttgcctg gtattattag caagcagcaa atatggcggt ggcgcgcgtg gacgcggctt      780

tgcctcccgg agaaggatca gtggtcaatt ggtcaggaca gggactacag aaattaggtc      840

caaatttacc ctgtgaagct gatattcaca ctttgattct ggataaaaat cagattatta      900

aattggaaaa tctggagaaa tgcaaacgat taatacagtt atcagtagct aataatcggc      960

tggttcggat gatgggtgtg gccaagctga cgttgcttcg tgtattaaat ttgcctcata     1020

atagcattgg ctgtgtggaa gggctaaagg aactagtaca tctggaatgg ctgaatttgg     1080

caggaaataa tcttaaggcc atggaacaga tcaatagctg cacagctcta cagcatctcg     1140

atttatcaga caataatata tcccagatag gtgatctatc taaattggta tccctgaaaa     1200

ccctgctttt acatggaaac atcatcacct ctcttagaat ggcacctgct tacctaccca     1260

gaagtcttgc tatactttct ttggcagaaa atgaaatccg agacttaaat gagatctctt     1320

ttttggcatc cttaactgaa ttggaacagt tgtcgattat gaacaatcct tgtgtgatgg     1380

caacaccatc catcccagga tttgactatc ggccgtacat cgtcagctgg tgcctaaacc     1440

tcagagtcct agatggatat gtgatttctc agaaggaaag tttgaaagct gaatggctct     1500

atagtcaagg caaggggaga gcatatcggc ctggccagca catccagctt gtccaatatc     1560

tggctacagt ctgccccctc acttctacac taggtcttca aactgcagag gatgccaaac     1620

tagagaagat tttgagcaaa cagaggtttc accagaggca gttgatgaac caaagccaaa     1680

atgaagagtt gtctcctctt gttcctgttg aaacaagggc atcccttatt cctgagcatt     1740

caagccctgt tcaagattgc cagatatccc aggaaagtga acccgtcatt caagtgaatt     1800

cttgggttgg gataaacagt aatgatgatc agttatttgc ggttaagaat aattttccag     1860

cctctgtaca cactacgaga tattctcgaa atgatctgca cctggaagac atacagacgg     1920

atgaggacaa gttaaactgt agtcttctct cttcagagtc tacttttatg ccagttgcat     1980

caggactgtc tccactatca cctacagttg agctgaggct gcagggcatt aacttgggcc     2040

tagaagatga tggtgttgca gatgaatctg tgaaagggct ggaaagccag gtgttggata     2100

aggaagagga acagccttta tgggctgcaa atgagaattc tgttcaaatg atgagaagtg     2160

aaatcaatac agaggtaaat gagaaagctg gactattacc ttgtcctgag ccaacaataa     2220

tcagtgctat cttgaaggat gataaccaca gtcttacatt ttttcctgag tcaactgagc     2280

agaaacaatc agacataaag aaaccagaaa atacacaacc agaaaataaa gaaaccatat     2340

ctcaagcaac ttcagagaaa cttcccatga ttttaaccca gagatctgtt gctttgggac     2400

aagacaaagt tgcccttcag aaattaaatg atgcagccac caagcttcag gcctgttggc     2460

ggggatttta tgccaggaac tacaaccctc aagccaaaga tgtgcgttac gaaatccggc     2520

tacgcagaat gcaagagcac attgtctgct taactgatga aataaggaga ttacgaaaag     2580

aaagagatga agaacgtatt aaaaaatttg tacaagaaga agctttcaga ttcctttgga     2640

accaggtaag gtctctacag gtttggcaac agacagtgga ccagcgtcta agttcctggc     2700

atactgatgt tcctcctata tcaagtactc ttgtgccatc gaaacatcca ttatttaccc     2760

aaagccagga gtcctcttgt gatcaaaatg ctgattggtt tattgcttct gatgtagctc     2820

ctcaagagaa atcattacca gaatttccag actctggttt tcattcctct ctaacagaac     2880

aagttcattc attgcagcat tctttggatt ttgagaaaag ttccacagaa ggcagtgaaa     2940

gctccataat ggggaattcc attgacacag tcagatatgg caaagaatca gatttagggg     3000

atgttagtga agaacatggt gaatggaata aggaaagctc aaataacgag caggacaata     3060

gtctgcttga acagtattta acttcagttc aacagctgga agatgctgat gagaggacca     3120

attttgatac agagacaaga gatagcaaac ttcacattgc ttgtttccca gtacagttag     3180

atacattgtc tgacggtgct tctgtagatg agagtcatgg catatctcct cctttgcaag     3240

gtgaaattag ccagacacaa gagaattcta aattaaatgc agaagttcag gggcagcagc     3300

cagaatgtga ttctacattt cagctattgc atgttggtgt tactgtgtag catgtctttt     3360

gggaggcaga tatccactta acttttctta aaaatacttt cagttgcctt tgcttttttt     3420

tggagggaaa tactccctac ccctaatttt gttactactt atatagaatt tgtattcatg     3480

tcttatattt ttcagattct agatattgag ctgagttttc attttgattt tgttagcttt     3540

ttacttagct gtaaggtacc aaactattta tattgaaagc tatatgcact ttatttctta     3600

actgaattgc atcaacaatg ttcctgtttc tttcatgtac tcatttactt tcaaaaataa     3660

gctagaatat attaaagaaa atagaaaaaa ttaccttaaa tatataaata agagaatttt     3720

ggcccttctg tgtctgagaa aattaattat atagcaagga atgaaatttg ataaagcaaa     3780

tataaatgag aaatatgagg attgtgaatt attgaaattt gccagtctcc ctggtgtaaa     3840

atgttttttt aaagcctttt ttcctccttt cggagtcaag gaaagccttt ctataagcaa     3900

attaaggaag aaaaggtagg attataagat ttctcaatgg ggatgattaa attgtctcat     3960

ggaaaacttc agttaatgtc atgcatcagt tttaacatat gaagtaaagt gttctatcca     4020

ggattaaagt caagtttact taggcaacac aagaatattt cacttagata tgaagaaagg     4080

aaacactagt ctccattcac ttgaaatact ctcatggcaa atatttatcc tctcattaag     4140

tgctttttca ccctataggt aagcattttt gtgccaacat gttgtcagaa attaatgtat     4200

gttcatctcc tctgttcctg cttattttta cttatatatt tcagcagaag gtccgtggcc     4260

attcacttca attttgacct ctgtcccata gtgaagaaca tttaaagtaa tactactggt     4320

cgaatatgaa tgacttttta ggaactactt tttgtctaac ctgaaaaagt tccacatttg     4380

gaagacaatt taatgatggt gaagaaataa taaacctcac tttacttgtt aaaagggata     4440

tatatatata tatatatgtc tgcaacttca gggagaaata agattgtgtt tgaatattgt     4500

aggtagatgc atttgtaatt aaggataata tcgtttaaca acatgtattt ggtttccctc     4560

aacttacaga catacagcta tttaaaacta tggcaatact taagcatctc taaatttagg     4620

tgctaaatat ctattattct gttgtagtca ttaggtgccc ttctctgaag ttatgtaaaa     4680

taaaagcatc tgatccttca aggataaagt tgaggatcac atggtacgtg gcatttgttg     4740

ttattgtttt ttaaagagat ggaggctggc tctgttggtg cggtgccatg atcatagttc     4800

actataacct cgaactcctg gctcaagtga tctcccactt cagcctcccg agtatctggg     4860

attataagca agagccactg ctcccagctc atggtatttg ttgatagtca taacattttt     4920

cctgtatggt aagacgtatt tttctcagtt tataaatacg tagcactcag gttgagacga     4980

cttggatttt attcttagaa atccagaatc ccttgaaaag gaaatatttt ctgtttctta     5040

taaataaaag agtaatctta ctttcagaag gattttcctt agtgaaacat gtgtaacatt     5100

gaatgcatgt taaataaaaa tggaatttct aacttttttt caatagtgct aattatcttt     5160

tctgaatgat tttgaatgtc ttcttaaata taccctattt ttctatttta aagttaagtg     5220

cctcacttgc tgtccatagt tagacaaaga aaaaccaatt tccactgcac tagtaccaaa     5280

atactacttt atacattagt ttttcataaa agctgctgga atgtcatgat tcagtattac     5340

ctaaatagat ttctgctaaa atcctctccc tcctgtcttt tttaagttat ggaaaaacac     5400

aactaaattc atttgatcat cagcacttgt tagcaggatt tcctttttta cctttgcctt     5460

gtttctttag cccacaaata gtactcagca tactttcatt aaaaatttgg cacaatatga     5520

taattgttaa tattctgttc ttcgtctgtg ttttatttaa cttttactag tgtttagaag     5580

tgcaagaata ttaaatagcc ccttccttaa ctgtacatat tatcttgaat gtagataaaa     5640

tgaaaatact gtaaattaga gtgtaggaaa actggcatag agttaatata ttttaatggg     5700

tttacattat actttaaaag taatttatat aattaaaata tttggtttta actctatggg     5760

ctattctttg gttggctgaa gagggaatgg gtctagtaag gtttggaaag ttaagctttg     5820

aacatggtct ttgtgttttt ttcctaacaa ggaaaggttt agttcagctg tgctatttta     5880

gtacacatca gttctcttga tttatggaag attcagttta tcaattaaga attcctgcag     5940

aagcacagaa tcataccatg taagagttgg aaggaagctt aagagatttc tgttcgaatc     6000

tctttgtttc aaagatgaaa ctaaagcaca gcatgttaaa tgacttgtct aagttatagc     6060

tagttagtag taaataaact gaaaacctat atgctactgt agtccaaaat tttattatgt     6120

cctcttaatc tttacattta gtgagtcagt aaggaaatct ctgcatattt ctcattctct     6180

ttgaaagagg aaaaaaactt ctaagagagc tacaactcta tcactcatga cagagttgct     6240

tgtagaaaat aactaattcc ttcagaaccc tgagtgaatt ttttctaaga aatgtgactt     6300

gattaaaatg gtttcaaaag agcaatagtg gaaattaaag ttttagaaaa gagacctggc     6360

gtggtggttg acaactgtaa tcccagtgct ttgggaggct gaggccagag gatcacttga     6420

ggccaggagt tcaagaccag cctggacaac atagcaagac ccccctctct acaaaaaaaa     6480

tttttttctg aaaagaataa gtacatttta gagtccattt atttgacgac aggcagtatg     6540

acaggttgct gaggtatata aaattttcta gagaaatgct gagtttgatg acattttatc     6600

ttcagttttg tagaacagat gttaaaatgt taactctcct ggtgtgcaga aagctgtaat     6660

catgacagtt gataatatgc aatttagttt gattttatag gtttaattat aaaaggcttc     6720

acaatatgca tgttttagga aaatgttcat ttatttagtc atataatcgt ttgtatatat     6780

gtaaataact ttattctgga ataatgtggg tgccatcttg agcgtgtgtt tttatctgtt     6840

ttggattatt ttttgtatac aaacaccata atactgtatt ttcctgttat ctacttaagt     6900

ctagttctac tttttcccaa taatttcagg aaaatacaag cttgagatat tatactatct     6960

cccttggtat tttttgtgtg caaagtctta gaattggatt tataacattg ataataaaaa     7020

tataaaacgt ttttcctcgg gagttaagat ggtaaaaaga aaaaaataga atgaatatga     7080

tcatttctcc atcataaagg aaagaagaga cttcattgtg tgtgtgtttt tttttttttt     7140

ttcgagatag agtttcactg ttgtcaccca ggctggtctc agctcactgc aacctccact     7200

tcctgggtac aagcgattct cctgcctcag cttcctgtgt agctgggatt acaggtgtgc     7260

aaccacaagg ctcggctaat ttttttgtat ttttagtaga gatggggttt caccatgttg     7320

gccaggctgg tctcgaactc ctgacctcaa gtgatccacc cacctcggcc tcgcaaagtg     7380

ctgagattac aggtgtgagc cactgtgccc agccgagact tcattgttta atgtatattt     7440

ttattttttc caaacaccag ctcgaatcag agtatatttt tattttgcca cataccttta     7500

aaaggtattt attgtgtcat aatgttttaa atgttaaata tatgataccc tcattcatga     7560

agtgaagcag aaagggtctg taaggaacat tctaaacatt tttaatgata ttgcttttac     7620

tgatcaagct tgttgtgcca tattaaaatt aaaagtcaaa taaacaaagc agtcctcaca     7680

gccttggaaa gaaatagata attgtcttct taagatgagg tgctttttat ctgtggatga     7740

atggaaatca cactgaattt taattcttat ttattttagt ggatagcagg aatcactctg     7800

tagtagttgt gttcattttc ttttcttttt cttttctttt ttttgagaga gtctcgctct     7860

gtcaccaggc tggagtgcag tggcgtgatc tcggctcact gcaacctcca tctcctgggt     7920

tcaagtgatt ctcctgcctc atcctcccga gtagctaaga ctacaggcac acgccaccat     7980

gcccagctaa tttttatatt tttagtagag atggggtttc accatgttgg ccaggatggt     8040

ctcaatctct tgacctcgtg atccacccag tttggcctcc caaagtgctg ggattacagg     8100

cgtgagccac tacacctggc cttgttcatc ttctaattaa atatctttga atgttttgta     8160

ataattttaa tgttgacaat aagagtttaa aaataatttg attttggact gtatttagat     8220

ttctctttaa ttttgctgta gaaatagtaa atgatttaaa gtggttatga tgtgttttat     8280

gaaggcttac tattttatat tgtacttatt taatttgtat ttgagtctgt ctaattttaa     8340

ataaaaggtt tatacatttg a                                               8361


<210> 1215
<211> 4992
<212> DNA
<213> Homo sapiens

<400> 1215
agccgcgatg ccgcgatgga gcgcagcccg ggcgggcgcc ggggccgggg cccgagcgcc       60

aggcggagcg cgagctggag ccgcagccgg agcccgggcc aggccggggg ccgggagcgc      120

agggccgggc tgctcgtagc ggcggcgacc gagcccccca gcggctgagg ggcttccagc      180

gcccgccggt ggccgggacc cactaaagcc cccgcagccg aggagtgcgg ggagccccct      240

tccacatcca ggatccggcg agcctcgggg aagagggggg gccctcccgg atccgacacc      300

gagcgactcc cctgcgggga aagcggagac ttcctcggta tttagaagac agcaagcccc      360

ctacggcacc gcaaggactc cccctcctca gtctgggccc ccgccccaag acctagaacg      420

cagtgccccc aggccgggat tgcgagaacc ccctcccaag atccggtcat tacaactcca      480

cacctcaaga caagaagacc cagctcagaa cgcccctaga tcaggggatc ccaattcccc      540

ccaactccgg tacatagaaa tcccaaatct aggcagccgg ggacagcaag agacactctc      600

accagcaaga agcctcgggg atcccccccc taaagctcca ggacttgggc gactgagccc      660

ctggcggcac cgcttgcacc ccggtccatg gtcgtggcgc cctgagcccc cggggccggg      720

cagacgaaga ccgcgacggc gcccaggccc cctgccgcgg cgtccccgcg gccccagccc      780

agggagaaga tgagcgtggg ctgcccagag cctgagccgc cccgctccct gacctgctgt      840

gggccgggga ctgcccctgg gcctggtgcc ggtgtgcccc ttctcactga agacatgcag      900

gccctgactc tccgcacact ggccgccagc gacgtcacca agcactacga actagtccgg      960

gagctgggca aaggcaccta tgggaaggtt gacctggtgg tctacaaggg cacaggcaca     1020

aaaatggcac tgaagtttgt gaacaagagc aaaaccaagc tgaagaactt cctacgggag     1080

gtgagcatca ccaacagcct ctcctccagc cccttcatca tcaaggtctt tgacgtggtc     1140

tttgagacag aggactgcta cgtctttgcc caggagtacg cacctgctgg ggacctgttt     1200

gacatcatcc ctccccaggt ggggctccct gaggacacgg tgaagcgctg tgtgcagcag     1260

ctgggcctgg cgctggactt catgcacggg cggcagctgg tgcaccgcga catcaagccc     1320

gagaacgtgc tgctgttcga ccgcgagtgc cgccgcgtaa agctggccga cttcggcatg     1380

acgcgccgcg tgggctgccg cgtcaagcgc gtgagcggca ccatccctta cacggcgcct     1440

gaggtgtgcc aggcgggccg cgccgacggg ctggcggtgg acacgggcgt ggacgtgtgg     1500

gccttcggcg tgctcatctt ctgcgtgctc accggcaact tcccgtggga ggcggcgtcg     1560

ggcgccgacg ccttcttcga ggagttcgtg cgctggcagc ggggccgcct gccggggctg     1620

ccttcgcagt ggcgccgctt caccgagccc gcgctgcgca tgttccagcg cttactggcc     1680

ctggagcccg agcgccgcgg cccagccaag gaggtgttcc gcttcctcaa gcacgagctc     1740

acgtccgagc tgcgccgccg gccctcgcac cgcgcgcgca agccccccgg ggaccgcccg     1800

cccgccgccg ggccactgcg cctcgaggcg cctgggccgc tcaagcggac ggtgctgacc     1860

gagagcggca gcggctcccg gcccgcgccc cccgccgtcg ggtcggtgcc cttgcccgtg     1920

ccggtgccgg tgccagtgcc cgtgccggtg cctgtgcccg agcccggcct agctccccag     1980

gggccccccg gccggaccga cggccgcgcg gacaagagca aagggcaggt ggtgctggcc     2040

acggccatcg agatctgcgt ctgagtcgcc tccgccgccc tcggacccgg gagcagcccg     2100

ggcccgcccc gagccggtgc ccggtgcggc ggtagggaat ggagccacct cgccgcgggg     2160

cagggggcgc agcggtagac taggcaggac gcggcccggc acctggtccg tccccggcgg     2220

gctggtgagg gggccaccaa agacccctag cgcggcctgg tgagcggggg cttggcccag     2280

aggagccaag ccgcacagac ccgagaattc ggaggccacc acacaacaca cacacacaca     2340

cacacacaca cacacacaca cacacacaca cacacacaca cgccaggagc aagggagctt     2400

tcgggccaca ctcccagacg cctccctgag ccctggaacc cggactcgtt gctcctggcc     2460

ttccataccc cctggcagat catcctgcgg tcccacccca gatcccctcc tcctcgccat     2520

cccattctgc cccctcccca ccctgggtac agaaagggac tgaagtgttg ggcagagagg     2580

gggcttaagg cccctgggca caggctggga tcagggcagt gagcgaaggg cagctgtgtc     2640

ctgccctccc ttctggaggc tggaggggag aggccaagcc cttggaaaat gtagcaaatg     2700

tctggatgtc gcataagtgc gtgtatgtgc gggacaggcc ccgagaagct agtgactcct     2760

gcacaccccc attgcacaaa tgaaatcaca gcccaggagg gagggtagct tggcactggc     2820

tgagaaatag agctctctcc ccgcccctcc ccctaaccac aagggattgt cctgacaact     2880

tgtggggata gaagggctca cagggcaggg gtctcagctg cccccatcct tagggcaggg     2940

gagttagtgt ggagccgaga gcaggtccca gctccccctg ccagccgcac tgtcccaggc     3000

ccagggacct ctgccgggtc ctcccagccc ttgccacaca gcctagacgt agtagcctgg     3060

gcttccagca ggtggcgagc tggttcgtgc tggaaatttc tcctgggttt cttggggtca     3120

aacatgccaa cctccaagac cccatcctca cgtctcccac ttttctggcg ctggagtgtg     3180

cagggcgtag gacctgcatg tgtgggtgtg agaatggggg cggtggacac cagggggcga     3240

gtgtgtgact aggtgtgtgt gcacatgtgt agggtgcaga cgcatgggtg ccatcctttg     3300

cgttcagtga ctgtgcgtcc agacccctca ccagcggccc ccccaccaca ccctggtcct     3360

cccaggcagc tgtcccaggg cgcccaggcc tgccttgcac cacagccctc aggaaatccg     3420

gcaaggaggc ccctgcaggt tggttcaggc ccccaggtag caaaacagag acaacagcag     3480

ccccgcctga ccccctgccc ctctctgtgg aggcccggga cccccgcaat aagcaccaca     3540

tgggtgaggc tgtccctgtc agggtcccct gccagggtcc ctcctggggt tctgggccat     3600

ttgaggggct ctttgatggg ccaggccggc cagagtgaac tccgagcact ttctggctgg     3660

tgccccaacc tctccactcc ccactcattc ccaccttgaa aaagggctat aggtcccctg     3720

ccctgcccgg gtccagttta caaacagtgt ggggtggccc cagggcctgg ccccactctc     3780

cctgctgtgc ccactcctct ccagactcca cctccccagt gggtatgggc cctccacatg     3840

ccaggtaagt agcaaacccc cactccctcc aaggaccagg tctcagagaa ggccctggtc     3900

actgcccccg gcccacctgg agcccatcgg ggctgcctct cccagccgcg acttctcctt     3960

ttgccttagg cctcgcgaca tcctgatctc tcctgcaata actaggaatc gagattccac     4020

agtagacgtc ccttgccgtg ctcgctctct ctctcgcgcg cgctctctct ctccctctct     4080

ctctctctct ctctctctct ctctctctct ctctctctct ctcctctctt tctctctctc     4140

cctctctctg ttaagatcct gttcgggagt ttccccagcc gttgtagtat ctagtatgtt     4200

agagttggga ggggaccata gttatgtagc ccagccccct cattcccaga ggcacccaga     4260

gggccagcct ccagcctgac cccagagcag aaccggaaca ccaggttggg gccctggtgc     4320

tgccacctcc tctgctggtc gggctgggac cctttgcccc ttaggagagg tgttggtcac     4380

agatgtttac ctcagtttat gtcactgtcg aagaaacaaa aaataatagc aaaaaataac     4440

actgtagaca tgaagactta gaagacaaaa aaaaaaaaat cacacaaaaa atctcccttg     4500

ttgcgattct tctgtgaagg tacagtgtgt atgtgtgtat gtgtgtatgt gtgtgcgtgt     4560

ctctgtccca gaccctgtgt cccccacact gccccctgtc cttcggtgct tcccagagac     4620

ccctctgagc tggcctgtgg ggcacgggaa gccccctgga tgggaggcgg ggccacaggt     4680

cggctagagg gtctccacca ggcccactga acagaacccc acggctgcca gaatgttccc     4740

tgagcccaca ctgtggccag tgggacagtc ctggtggctg acatcagcgt ccatgcttgg     4800

ctcagggcct ggggcggggt cctgggtaga gtcctagccc cagagcccca gcccctcatg     4860

tcttgccgcc cttcctccat gtgtttgtaa atactctggc atcctttggc cctgagaagg     4920

tttttaaatg tgttatttac ttctctaaac atgacgattg ctataaaaat aaacaaaagt     4980

ttagaaaaat ga                                                         4992


<210> 1216
<211> 1739
<212> DNA
<213> Homo sapiens

<400> 1216
ggtcaccatg gcgaccaggc gccttggggt cggggagacg ctgggggccc tcaacgcggc       60

cctggggcca ggcggtccgg tgtggatcaa ggagacgcgc acccgccacc tgcgttcccg      120

agactttctg gcaccgcacc gcgcgctgca ggcgcgcttc gatgacggcc aggttccgga      180

gcatttgctc catgccctcg cctgcctgca gggccccggt gtggccccgg tgctgcgctg      240

cgcgccgacc cccgcgggtc tgtctctcca actgcagcgg tccgccgtct tcgagcgcgt      300

cctcagcgcc gtggccgcct atgccacgcc cgcctcgcct gcctcgctgg gccagcgcgt      360

cttactacac tgcccagcac tgcgcagctc cccctgcgca ctccgcttga gccagctgcg      420

tacggtgctc gtggccgatc acctggcgcg agccctgcgc gctcacgggg tgtgcgtgcg      480

cctagtgcca gctgtgcggg atccgcacat gctgaccttc ctgcagcaac tgcgggtgga      540

ctggcccgct gcctcggaga gagcttcctc ccacaccctg aggagccacg cccttgaaga      600

acttacctct gctaatgacg ggaggacact gtcccctggc atcctaggca gactgtgtct      660

gaaggagctg gtggaagaac agggccgcac agctggctat gaccccaacc tggacaactg      720

tctggtgact gaggatctcc tctctgtgct ggctgagctg caagaggctc tatggcattg      780

gcccgaggac agccacccag gcctggctgg ggcctcagat actggtacag gcggctgcct      840

ggttgtacat gttgttagct gtgaggagga gttccagcaa cagaagttgg acctgctttg      900

gcagaagttg gttgacaagg ctccactcag acagaagcac ctcatctgtg gccctgtgaa      960

agtagctggt gcacctggca ctctgatgac tgcccctgag tactacgagt tccggcatac     1020

ccaggtgtgc aaggcctcag cactgaagca tggtggggat ctggcacaag acccagcctg     1080

gacagagatc tttggtgttc tctctgtggc caccatcaag tttgagatgc tgagcacagc     1140

cccacagagt cagctcttcc tggctctggc tgacagcagt atctccacga agggcacaaa     1200

gagtggcacc tttgtcatgt ataattgtgc ccgtcttgcc acactctttg agagttacaa     1260

gtgtagtatg gaacaaggtc tgtaccccac ttttcctcct gtgagcagtc tggacttctc     1320

actgctacat gatgagggtg agtggttgtt gctcttcaac agtatcctcc cctttccgga     1380

tctgctgagc cggacagcag tgctggactg cacagccccg gggctccaca ttgctgtacg     1440

cacagagatg atatgcaagt tcctggtaca gctcagcatg gatttcagct cctactacaa     1500

ccgggtacac atcctggggg agcctcgacc acacctcttt ggtcagatgt tcgtccgcct     1560

gcagcttctg agagctgtgc gtgaggtgct ccatactggc ctggctatgc tgggtctccc     1620

tccactgagc cacatttaag gccacagagg ctccaatacc tgggaatgtt cacaaagtca     1680

tcaactggaa aaaaagcaaa aacccacggc caaaataaat tggtactgtt tgttacaaa      1739


<210> 1217
<211> 1921
<212> DNA
<213> Homo sapiens

<400> 1217
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat       60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg      120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa      180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa      240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat      300

ttcatgtatg aagccccacc aggagctaaa aaagaaaaca aagagaaaga agaaacagaa      360

ggagagaccg aatacaaatt tgaatggcag aaaggagccc cacgagaaaa atatgccaaa      420

gatgacatga acatcagaga tcagcccttt ggtattcagg ttcgaaatgt gaggtgcatt      480

aaatgtcaca aatggggtca tgtcaacaca gatcgagaat gtcctttgtt tggtctttct      540

ggaatcaatg caagttcggt tcccactgat ggctcagggc catcgatgca cccctcggag      600

ctaatagcgg agatgagaaa cagtgggttt gcactgaaac gaaatgtact ggggagaaac      660

ttgaccgcaa atgatccatc acaggagtat gttgcaagtg agggtgaaga agatccagaa      720

gttgaatttt taaagtcact aacaaccaaa caaaaacaga aacttctcag gaaattagat      780

cgactggaga agaaaaaaaa gaaaaaagat agaaaaaaga aaaagtttca gaagagcaga      840

agtaaacaca aaaaacataa gtcctcttct tcctcatctt cctcctcctc ctcctcttcc      900

tctactgaga cttcagaaag cagtagtgag agtgagagta acaataaaga aaaaaaaata      960

caaaggaaga aaagaaagaa aaacaagtgt tcagggcata acaacagtga ttctgaagag     1020

aaggacaagt ctaagaagag aaagcttcat gaagaacttt ctagcagtca ccataaccgg     1080

gaaaaagcca aggaaaagcc caggttctta aaacacgaga gttctaggga ggacagcaaa     1140

tggagccatt ctgattctga caaaaagtcc agaacccata aacatagccc agagaagaga     1200

ggctctgaaa gaaaggaggg gagcagcaga agccacggca gggaggaaag gagccggaga     1260

agccggagca gaagtcctgg tagttacaag caaagggaga caaggaaacg ggcacagcga     1320

aatcctggtg aagagcaaag cagaagaaat gacagcagaa gccatggcac agacttgtat     1380

agaggagaaa aaatgtacag agagcaccca ggaggtacac atactaaagt gacacaaaga     1440

gaatgaagca gaagtagaga agaaagactg tatgtgacaa ttacctggga ataaaaatat     1500

ctccactttt ttattgaata cctttagcaa ggggtaaatt atgtactgtt gtctttctaa     1560

taaaaaagct caattttaat ttttcatctc tagactgtca attcaagtac aaaactacat     1620

gagtactata agaatgaatt ttgcaaatat ttgtaagtaa gctattttgg ggctgtggaa     1680

atattttctg ttggtaactg tttcttgttc cccataccag ataaaaaccg catataactc     1740

tgtgacattt tctttgttct gaaacatcat taaaagaatg acagtacatt gaatgggtat     1800

aatttacttt tttcaattca aatttgttat tctaggattt gaatttgctt gaagtgaatt     1860

gtaataatta ttcaaattca ttagtataaa ttaaggatta ataaatcttt aagactttta     1920

a                                                                     1921


<210> 1218
<211> 1681
<212> DNA
<213> Homo sapiens

<400> 1218
gggtacctgt accccacgta gtcgccggtt accgatcgga ctaagttcca gaagcaagag       60

ataaagtaat aatgggtact gtggggaaaa acacagaaga acaattcggt aatatagtgg      120

tgatttacaa gtcaagttaa aatgtcccca gaagtggcct tgaaccgaat atctccaatg      180

ctctcccctt tcatatctag cgtggtccgg aatggaaaag tgggactgga tgctacaaac      240

tgtttgagga taactgactt aaaatctggc tgcacatcat tgactcctgg gcccaactgt      300

gaccgattta aactgcacat accatatgct ggagagacat taaagtggga tatcattttc      360

aatgcccaat acccagaact gcctcccgat tttatctttg gagaagatgc tgaattcctg      420

ccagacccct cagctttgca gaatcttgcc tcctggaatc cttcaaatcc tgaatgtctc      480

ttacttgtgg tgaaggaact tgtgcaacaa tatcaccaat tccaatgtag ccgcctccgg      540

gagagctccc gcctcatgtt tgaataccag acattactgg aggagccaca gtatggagag      600

aacatggaaa tttatgctgg gaaaaaaaac aactggactg gtgaattttc agctcgtttc      660

cttttgaagc tgcccgtaga tttcagcaat atccccacat accttctcaa ggatgtaaat      720

gaagaccctg gagaagatgt ggccctcctc tctgttagtt ttgaggacac tgaagccacc      780

caggtgtacc ccaagctgta cttgtcacct cgaattgagc atgcacttgg aggctcctca      840

gctcttcata tcccagcttt tccaggagga ggatgtctca ttgattacgt tcctcaagta      900

tgccacctgc tcaccaacaa ggtgcagtac gtgattcaag ggtatcacaa aagaagagag      960

tatattgctg cttttctcag tcactttggc acaggtgtcg tggaatatga tgcagaaggc     1020

tttacaaaac tcactctgct gctgatgtgg aaagattttt gttttcttgt acacattgac     1080

ctgcctctgt ttttccctcg agaccagcca actctcacat ttcagtccgt ttatcacttt     1140

accaacagtg gacagcttta ctcccaggcc caaaaaaatt atccgtacag ccccagatgg     1200

gatggaaatg aaatggccaa aagagcaaag gcttatttca aaacctttgt ccctcagttc     1260

caggaggcag catttgccaa tggaaagctc taggaaacac cagtcttgag aggtggccag     1320

ccagactgcc tgtccacatg cgtgtcagca catacagccg cttcctggaa gccgcctgga     1380

atgtcttcac ggcagcgttt tgctcacaca gcagcttttg cacgccccag gcagccccga     1440

ctgctgaaat ccaacttgag ctggctggtg gtccctggat cctagagccc ttcacttcgg     1500

gttactccct ctttcttgcc tctatttctt agttggaaga aataaactca caaattatgg     1560

tgcagtaatt ttccggggaa agtaaagcct caggaatgcc cacgcctttc ttccaaagcc     1620

tttgtctctg agacctctta agttctaaga ttaaatgccc ctcgctgttc ttcctctgaa     1680

a                                                                     1681


<210> 1219
<211> 2959
<212> DNA
<213> Homo sapiens

<400> 1219
gggtgacgca ggcgcagcgc gggctgcgcg cgctactgcc catccccggt tgtcccactt       60

ttgttcgcct ctcttcggcc ctctactcaa gagctccgtc tccgtctcgc cctcctcgaa      120

gtcctcgtcg cgcgcccgcg acccaggtcg ccctgaaatc tagcccgtcc gagcgcgagt      180

ccaacgccgc ggccgcacca aggccccctc agaccgtgcc atgggtgaca gtgatgacga      240

gtacgatcga aggcgcaggg acaagttcag aagagagcgc agcgactacg accgttcccg      300

cgagagagat gaaagacgtc gaggggacga ttggaatgac agagagtggg accgtggccg      360

tgagcgccgt agtcggggtg aatatcggga ctatgaccgg aatcggcgag agcgcttctc      420

gccacctcgc cacgaactca gcccgccaca gaagcgcatg aggagagact gggatgagca      480

cagctctgac ccataccaca gtggctatga gatgccctat gctggggggg gtgggggccc      540

aacttatggc ccccctcagc cctggggcca ccctgacgtc cacatcatgc agcaccatgt      600

cctgcctatc caggccaggc tgggcagcat tgcagagatt gacctgggtg tgccgccgcc      660

cgtgatgaag accttcaagg agtttctcct ctccctggat gactcggtgg atgagacgga      720

ggccgtcaag cgctataatg actacaagct ggatttccgg aggcaacaga tgcaggattt      780

cttcctggcg cacaaagatg aggagtggtt tcggtctaag taccacccag atgaggtggg      840

gaagcgtcgg caggaggccc ggggggccct gcaaaaccga ctgagggtct tcctgtccct      900

catggagact ggctggtttg ataaccttct cctggacata gacaaagctg atgccattgt      960

caagatgctg gatgcagccg tgattaagat ggaaggaggc acggagaatg atcttcgcat     1020

cctggagcag gaggaggagg aggagcaggc aggaaagcct ggggagccca gcaagaaaga     1080

agaaggacgg gctggagcag gcctagggga cggggagcgc aaaaccaacg acaaggatga     1140

gaagaaggaa gacggcaagc aggctgagaa tgacagttct aatgatgaca aaacaaagaa     1200

gtcggagggt gatggggaca aggaagagaa gaaagaagac tccgagaagg aagccaaaaa     1260

gagtagcaag aagcggaacc ggaagcacag tggtgacgac agctttgacg agggcagcgt     1320

gtcagagtct gagtcggagt cagagagcgg ccaggctgag gaggagaagg aggaggccga     1380

agcgctcaag gagaaggaga agcccaagga agaagaatgg gagaagccca aggacgccgc     1440

ggggctggag tgcaagccgc ggccgctgca taagacctgc tccctcttca tgcgcaacat     1500

cgcgcccaac atctcccggg ccgagatcat ctccctttgt aaaaggtacc caggctttat     1560

gcgggtggcg ctctcagagc cccagccaga gaggaggttt ttccgtcgtg gctgggtgac     1620

cttcgaccgc agtgttaaca ttaaagagat ctgttggaac ctgcagaaca tccgtctccg     1680

ggagtgtgag ctgagccctg gtgtgaacag ggacctgacc cggcgcgttc gcaacatcaa     1740

cggcatcacc cagcacaagc agattgtgcg caacgacatc aagctggcgg ccaagctgat     1800

ccacacgctg gatgacagga cacagctttg ggcctcagaa ccagggacgc ctcccctgcc     1860

cacgagcctg ccctcgcaaa acccgatctt gaagaatatc accgactacc tgatcgagga     1920

agtaagcgcc gaggaggagg agctgctggg gagcagcggg ggcgctcctc ctgaggagcc     1980

tcctaaggaa gggaacccgg cagagatcaa cgtggagcgg gatgagaagt tgattaaggt     2040

cttggacaag ctcctccttt acctgcgcat cgtgcattcc ttggattatt acaacacctg     2100

tgagtacccc aacgaggacg agatgcccaa tcgctgtggg atcatccacg ttcgggggcc     2160

catgccaccc aaccgcatca gtcacgggga agtgctggag tggcagaaga cttttgagga     2220

gaagctcacg ccgttgctga gtgtgcggga gtcactctca gaggaagagg cccagaagat     2280

ggggcgcaaa gacccagagc aggaagtgga gaagttcgtc acctccaaca cgcaggaact     2340

gggcaaggat aagtggctgt gtcctctcag tggcaagaaa ttcaagggtc ctgagtttgt     2400

gcgcaaacat atcttcaaca agcatgcaga gaaaattgag gaagtgaaaa aggaagtcgc     2460

gttttttaac aacttcctca ctgatgctaa gcgcccagct ctgcctgaga tcaagccagc     2520

ccagccacct ggccccgccc agatactccc cccaggtttg accccaggac tcccctaccc     2580

acaccagact ccccagggcc tgatgcccta tggtcagccc cggcccccga tcgggctatg     2640

gagctggtgc tgtccgccct gctccccaca ggaggccctc cataccccca tgccccgtat     2700

ggtgctggtc gagggaacta tgatgccttc cgaggccagg gaggttatcc tgggaaacct     2760

cgcaacagga tggttcgtgg agacccaagg gccattgtgg aatatcggga cctggatgcc     2820

ccagacgatg ttgatttctt ttgagccgtc ccccgttcct cagtcctgta tcatccatac     2880

ttgtactacc ttgtcctatg aagctctgag aattttttgt acgatcagcc ttactgctaa     2940

taaaagcact tccacaggg                                                  2959


<210> 1220
<211> 6472
<212> DNA
<213> Homo sapiens

<400> 1220
aggggcggag gtgacagcgg gctggggact ggcggctgca actgcctgcc gcgccgaggg       60

accgccgggc ggcggaaagc aggttataaa acatggaggc tggctcagtg gttcgagcca      120

tttttgactt ctgccctagc gtatcagaag aactgccgct ctttgtggga gatattattg      180

aggtgctggc agtggtggat gaattttggc ttctaggaaa gaaggaggat gttacaggac      240

aattccccag cagttttgtg gaaattgtga ccattcccag tctaaaagag ggagagaggc      300

tgtttgtgtg catttgtgaa ttcacatccc aagagttgga taatcttccc ctccatcgag      360

gtgacctggt gattctcgat ggcattccca ctgcaggctg gctgcagggc cgaagctgct      420

ggggcgcacg gggcttcttc ccatcttcat gtgtccgcga gctctgcctc tcctcacaga      480

gccggcagtg gcactcccag agcgccctgt ttcagattcc ggaatattcc atgggacaag      540

cccgggccct aatggggctt tctgctcagc tggatgaaga gctggacttc agggaagggg      600

atgtgatcac cattattgga gttcctgaac caggctggtt tgaaggggag ttagagggcc      660

gaagaggcat ttttccagaa ggttttgtag agctgttggg gcccctgagg actgtggatg      720

agtcagtaag ttctggaaat caagatgact gcattgttaa tggtgaagta gatacccctg      780

taggagaaga agagataggg ccggatgagg atgaggagga gccagggacc tatggggtcg      840

ccctgtacag attccaagcc ctggagccaa atgagctgga tttcgaggtc ggggataaaa      900

tccgaattct ggcgaccttg gaagatggct ggctggaagg atccctgaag ggcaggacag      960

gcatctttcc ttaccggttt gtgaaattat gtcctgacac acgggtggag gaaaccatgg     1020

ctctgcccca ggaaggcagc cttgccagga tcccggaaac ttctttggat tgtttggaga     1080

acaccttagg agtagaggaa caaagacatg aaaccagtga ccatgaggcc gaggagcctg     1140

actgcattat ttctgaagca cccacttctc ccctcggtca tctgacttca gagtatgaca     1200

cagacagaaa ctcttatcag gacgaggaca ccgcaggagg gcccccgaga agcccaggcg     1260

tggagtggga aatgcctctt gccacagact ctcccacatc tgaccctaca gaagtagtca     1320

atggtatttc ctcccaacct caggtccctt ttcatcccaa cttgcagaaa agccagtatt     1380

attctacagt gggagggagc cacccgcact cagaacagta ccccgacctt cttcccctag     1440

aagcaaggac tagagactat gccagcctac ctcccaaaag aatgtattcc cagctaaaaa     1500

ctcttcagaa gccagtgctc cctctttaca ggggctcttc tgtttcagct tcaagggtag     1560

tcaaacccag acaatcaagt cctcagctcc acaacctagc aagttatact aaaaagcacc     1620

acacgtccag tgtttactcc atctcagaga gattggagat gaagcctggt ccgcaagccc     1680

aagggcttgt tatggaagca gcaacacatt cacagggaga cggcagcact gacctggact     1740

cgaagctgac acaacagctg atcgagtttg agaagagctt ggcagggccc ggcacagagc     1800

cagataaaat tttacgccac ttttcaatca tggactttaa ctctgagaag gatattgtcc     1860

gaggttcctc aaagttaatc accgagcagg agctgccgga aaggagaaag gccctaaggc     1920

caccgccacc tcgtccctgt actccggtat ccacttctcc ccatttgctg gttgaccaga     1980

acctaaaacc tgcaccaccc ttggtggtgc gaccctctcg cccagctccc ctgcctccct     2040

cagcacagca gagaacgaat gcggtatccc ccaagctcct atctcgacac cgtcctacct     2100

gtgagacctt agaaaaggag ggccctggtc atatgggaag gagtctggac cagacctccc     2160

catgcccctt agtgctggtg aggattgagg aaatggagcg ggacttggat atgtacagta     2220

gagctcaaga agagctaaac ctcatgctgg aggagaagca ggatgaatca tcaagagcag     2280

agaccctcga ggatctcaag ttctgtgaaa gtaacattga aagtttgaat atggaactcc     2340

agcaactaag agaaatgacg ctcctctcct cccagtcttc atcactggtg gccccttctg     2400

ggtctgtgtc tgccgaaaat ccagagcaga ggatgctgga gaagagagcc aaggtcatag     2460

aagaacttct tcagacagaa agagactaca ttcgggatct ggaaatgtgt attgagcgga     2520

tcatggtacc catgcagcag gcacaggtac caaacattga ttttgaggga ctttttggaa     2580

atatgcagat ggtgattaag gtctcgaagc aattattggc tgctctggaa atcagcgatg     2640

ctgtaggacc tgtgtttctt ggtcaccggg atgagcttga gggaacatac aagatttact     2700

gccagaatca tgatgaggcc attgcgctgc ttgaaatcta cgagaaggat gagaagatcc     2760

agaagcatct tcaggactcc ttggcagatc tgaagagcct atacaacgaa tggggatgca     2820

caaattatat taacctgggc tccttcctca tcaaaccagt acagagagta atgcgttacc     2880

cgctgttgct aatggagttg ctgaattcca ccccagaatc ccacccagat aaagtgcctt     2940

taaccaatgc agtccttgcg gtcaaggaaa tcaacgttaa cattaatgaa tataaacggc     3000

gaaaggacct gggtaagaac agcataattg ctgaaaagga gtatgcccat gctgaggaaa     3060

gtgcttttct gacttactcc ctagtcctca agtaccgtaa gggtgatgaa gatagcctta     3120

tggagaaaat ttccaaactg aacatccact ccatcatcaa gaaatccaac cgagttagca     3180

gtcacctgaa gcatctcact ggctttgctc ctcagataaa agatgaagta tttgaagaaa     3240

cagaaaaaaa cttccgaatg caagaaagat tgattaagtc ttttatccga gacctgtctc     3300

tctacctcca gcacatccgg gagtccgcat gtgtgaaagt ggtggctgct gtgagcatgt     3360

gggatgtgtg catggagaga ggacaccggg acctggagca gtttgagagg gtgcatcgct     3420

acatcagtga ccagctcttc acaaacttta aggagaggac agagcggctt gtcatctccc     3480

ccttaaatca gttactgagc atgtttacag ggccccataa gctggtacag aaacgctttg     3540

acaagctcct ggacttctat aactgtacag aacgggcaga aaagctaaag gacaagaaga     3600

ccctggagga gctgcagtcg gcccggaaca actatgaggc cctgaatgca cagctgctgg     3660

atgagctgcc caagttccac cagtacgccc agggcctctt caccaactgt gtccacggct     3720

atgctgaagc ccactgtgac tttgtgcacc aggctctgga gcaattaaag ccactgcttt     3780

cgttactcaa agtggctggc agagagggaa accttattgc catcttccac gaagagcaca     3840

gcagagttct gcagcaactc caggttttta ccttcttccc ggagtctctt ccagctacca     3900

agaagccatt tgagaggaaa accattgacc gccagtctgc tcgaaagcca ctcctgggcc     3960

tgccaagtta catgctacag tcagaagaac tccgggcctc cctcctggcc aggtatcccc     4020

ctgaaaaact cttccaggca gaacggaact tcaatgctgc tcaagacttg gatgtctcac     4080

ttttggaagg tgacctggtg ggtgtgatta agaaaaaaga ccccatgggc agccagaacc     4140

gctggctgat tgacaatgga gtcaccaaag gcttcgtgta cagctctttc ctaaagccct     4200

acaatcctcg ccgcagccac tccgatgcct ccgtgggtag ccactcctcc acagagtctg     4260

agcacggcag ctcctccccc aggttcccac gccagaacag cggcagcacc ctgaccttca     4320

accccagcag catggctgta tcctttacct cggggtcttg ccagaagcag cctcaagatg     4380

catctcctcc gccaaaagaa tgtgaccaag gaactctcag tgcatcccta aatccgagta     4440

attcagagag tagtccttcc agatgccctt cagacccaga ctccacctcc cagccaaggt     4500

caggggactc tgcagatgta gctagagatg taaagcaacc cactgccacg ccgaggagct     4560

accggaactt caggcatcca gaaatagttg gctactccgt accaggacga aatgggcaaa     4620

gtcaagacct cgtcaaagga tgtgcaagaa cagcccaggc tccggaagac agaagtacag     4680

agccagatgg cagtgaggca gaaggcaacc aggtctattt tgctgtctac accttcaagg     4740

cacgaaaccc aaatgagctg agcgtgtcag ccaatcagaa actcaagatc ctcgagttta     4800

aagatgttac aggaaataca gagtggtggt tagctgaggt taacgggaag aagggctacg     4860

ttccctccaa ttatatccgc aaaaccgagt acacctgagc ccacgttgcc tgccacccag     4920

ccttgctgcc tttgctttca gtccgccgag ggttctggcg gcccaccgag agggcgcctg     4980

ctcctgagac acaggccctg tctgcgttgc ttaaccatgg catggtggag cacaccacag     5040

atcttgttct cctcgattgg gttgtaaacc ttgatgctca ctagaatctc tagaatttga     5100

aatggaccct ggggctttgc aaatgactta gtgactatga gaagagagac aagtcttaga     5160

gctggctttt ggaaaggaga aacttgcagt cagaagccca gtgtcctatg tatgcaggaa     5220

gctgtgctct agcaatagac agtgttggta atggttgtgc tgtacggcgt ttggggtggc     5280

cccatgttcc atgctcagct gaccggatgc caactcagat gaaaagaatt catggctctg     5340

ggcaccccgt gaggcagtgc ttgcacatgg ctgggagttt gtcgggattg aaccaaacct     5400

agtgcttcaa agctcctggg acacctccag tgtccagcac acattctcat acatactgcc     5460

cctaatttct aaagtcccta aagcactaca ttctgtaacc ttgtttcttt tactccattc     5520

ccagattagt tatgcaaaat tcaactgcgt tctactttta gaagtgttta gggtctttat     5580

tttctgttga cccttcatct gaaagattct cttcccttgt taggtacaat cactgccccc     5640

ccgctttttt ttttgagatg gggtcttgct atgttgccca ggctggtctt aaacgcctgg     5700

gctcaagcaa ccctcccgcc tccctgctga gattacaggt gtaagccacc ataccgcaac     5760

ctcaatgaca cctttctgat ggtctttaca cagtctgtga tgtctggtgg cccccctgcc     5820

ctggactcaa taattgatag attttcctag agtaacagta tgagagctcc agccattcca     5880

ttaaaagtat tagttctgct ttgagctgaa accagttgag cctaatggaa gactggatgt     5940

ctttcttctt catccaagca ccctaatgac tgtttagtta catccataga tgcagacaac     6000

ataacacctg tgacttactt gaattgggat aagccattcc agaagtagct tatcctagac     6060

ttggaaataa gatttttttc accactaact tccatgcttc agagatgaca ttcaaagcca     6120

gattcccaag tgcctgatca tacctcccag tctcaggaag atatttgctt accccttaga     6180

ccaagaatct taagatcttc cccagctatg aagcctatct tggaatggga aaccatgaaa     6240

tttgtctttt aaaagaaagg gaagaaatag ccttacagcc cctgttcctc caagtgcaca     6300

tttagcctta aaatcctggg agtcgggaga caccgtggag tcctaacatc cacagtgtct     6360

gctggtcgtg gtcagaaggc agtaatgcaa gagtcctttt gtgaagagtg tttctatgta     6420

gagatgttta tatttaagta gttcttttat aaataaaagc atttctaatg gc             6472


<210> 1221
<211> 2309
<212> DNA
<213> Homo sapiens

<400> 1221
gcgctcccgc ttgccgcagc ctgcgtcgtc tgccgccacc gcgcgccttc actgacctac       60

accaccgccg ccgccgccgc cgccgccggg ctcgctggct ggcccggtgc gggcggcgga      120

ctcccgccgg agaggactgc cagcgccgcc gccgccgccg cttcggcccg ggcccgggcc      180

ccgaccccgt cccgggcccc agcgccggcc gcccgcccgg tcgggcgatg aagtgtcact      240

atgaggcgct gggggtgcgg cgcgacgcca gcgaggagga gctcaagaag gcctatcgga      300

agctggccct gaaatggcac ccggataaaa atctggataa tgccgcagaa gcagctgaac      360

aatttaaatt aatccaagca gcatatgatg tgttgagtga ccctcaggaa agagcatggt      420

atgataatca tagagaggcc ctacttaaag gtgggtttga tggcgaatat caagatgaca      480

gcttagattt gctacgctat ttcaccgtta cctgttattc tggttatgga gatgatgaaa      540

agggatttta cacggtgtat cgtaatgttt ttgaaatgat tgccaaggaa gaactagaat      600

ctgtgttaga ggaagaggtt gatgatttcc caacttttgg agactcccag agtgactatg      660

atacggtagt ccatcctttc tacgcttatt ggcagagttt ctgcactcaa aagaattttg      720

catggaagga agaatatgat acacgacagg cttcaaaccg ctgggaaaaa cgagccatgg      780

aaaaagaaaa caaaaagatt cgggacaaag caaggaaaga gaagaatgag cttgtccgtc      840

agctggtagc tttcattcgt aaaagagata aaagagtgca ggcgcatcga aaacttgtgg      900

aagaacagaa tgcagagaag gcgaggaaag ccgaagagat gaggcggcag cagaagctaa      960

agcaggccaa actggtggag cagtacagag aacagagctg gatgactatg gccaatttgg     1020

agaaagagct ccaggagatg gaggcacggt acgagaagga gtttggagat ggatcggatg     1080

aaaatgaaat ggaagaacat gaactcaaag atgaggagga tggtaaagac agtgatgagg     1140

ccgaggacgc tgagctctat gatgaccttt actgcccagc atgtgacaaa tcgttcaaga     1200

cagaaaaggc catgaagaat cacgagaagt caaagaagca tcgggaaatg gtggccttgc     1260

taaaacaaca gctggaggag gaagaagaaa atttttcaag acctcaaatt gatgaaaatc     1320

cattagatga caattctgag gaagaaatgg aagatgcacc aaaacaaaag ctttctaaaa     1380

aacagaagaa aaagaaacag aaaccagcac agaattatga tgacaatttc aatgtaaatg     1440

gacctggaga aggagtaaag gttgatccag aagatactaa cttaaatcaa gacagtgcca     1500

aagaattgga agatagtccc caggaaaatg tcagtgtcac agagatcatt aaaccatgtg     1560

atgatccaaa aagtgaagct aaaagtgttc ctaaacccaa aggaaagaaa accaaagata     1620

tgaaaaaacc tgtcagagta cctgctgaac cacaaacaat gagtgttctt atcagctgta     1680

caacctgcca tagtgaattt ccatctcgga ataaactttt tgaccatcta aaggccacag     1740

gtcatgcaag agcaccttca tcatcgtctt taaacagcgc aacaagtagt caaagcaaga     1800

aagagaaacg taaaaacaga tagagattct gcctgtgctt ttgtttgact gtctctagat     1860

tttgaaacca aaaaactgaa ctgaaatcat ctaaagagtt aaaatttcag tgatctgcaa     1920

ttaattacat tgtggaagat tattttttat cttgtaaaaa cacttttttg gtttaatata     1980

tatttttaaa acatttcact agtgattgaa ttctactttt gccatctgaa ttgacttgaa     2040

tgtcttaaaa caggtaaata ctgtaaagtg tgtattcttg atgtttattg gctcatgtgg     2100

acagaaatgt acagggagaa ttacattatt ttaacacaca gaagtgcaac tttctgcttt     2160

attttctgaa tttcacatta cttttactta atgcttttgt gttttgttaa tacttcataa     2220

tatgtgaaaa actcggatct tttaaaaagc atcatagatc atttttccat atgacactgg     2280

ttccgatttt aaaaattatt tttaaataa                                       2309


<210> 1222
<211> 1741
<212> DNA
<213> Homo sapiens

<400> 1222
tctgcagcca cgagaagcaa agttgacatt tctggatcac tctccccaga cgcgtcactt       60

gcccacaagc gggacacggc agtctcgctg agccagctgt gcagagggac agatggaaga      120

aagctagaga tgctgcttcg tgggcgctga agttgcagaa cttgggctgg ttttctttct      180

tcccatcccc cctcctcctg acaaaccaca tcttgactca gatggtcgaa agaaaaactc      240

tttcagttat ttgatatttg ggaaccctcc aggagaccat aacttatttt tgagggaggc      300

tccttctctc cctttgctgg gaacacacac acacacacac acacacacac acacacacac      360

acacacacac agctgtacac catggtggtt caggctgcag tggctccgaa tagatcccaa      420

agacttttac tgaaaattcc ttatggatct ctgagaaggc gcagcgttga aaggatgacg      480

gagggccgcc gatgtcaagt acatcttctt gatgacagga agctggaact cctagtacag      540

cccaagctgt tggccaagga gcttcttgac cttgtggctt ctcacttcaa tctgaaggaa      600

aaggagtact ttggaatagc attcacagat gaaacgggac acttaaactg gcttcagcta      660

gatcgaagag tattggaaca tgacttccct aaaaagtcag gacccgtggt tttatacttt      720

tgtgtcaggt tctatataga aagcatttca tacctgaagg ataatgctac cattgagctt      780

ttctttctga acgcgaagtc ctgcatctac aaggagctta ttgacgttga cagcgaagtg      840

gtgtttgaat tagcttccta tattttacag gaggcaaagg gagatttttc tagcaatgaa      900

gttgtgagga gtgacttgaa gaagctgcca gcccttccca cccaagccct gaaggagcac      960

ccttccctgg cctactgtga agacagagtc attgagcact acaagaaact gaacggtcag     1020

acaagaggtc aagcaatcgt aaactacatg agcatcgtgg agtctctccc aacctacggg     1080

gttcactatt atgcagtgaa ggacaagcag ggcataccat ggtggctggg cctgagctac     1140

aaagggatct tccagtatga ctaccatgat aaagtgaagc caagaaagat attccaatgg     1200

agacagttgg aaaacctgta cttcagagaa aagaagtttt ccgtggaagt tcatgaccca     1260

cgcagggctt cagtgacaag gaggacgttt gggcacagcg gcattgcagt gcacacgtgg     1320

tatgcatgtc cggcattgat caagtccatc tgggctatgg ccataagcca acaccagttc     1380

tatctggaca gaaagcagag taagtccaaa atccatgcag cacgcagcct gagtgagatc     1440

gccatcgacc tgaccgagac ggggacgctg aagacctcga agctggccaa catgggtagc     1500

aaggggaaga tcatcagcgg cagcagcggc agcctgctgt cttcaggtag gcagaggcca     1560

gctggaggga cgccccctga gcatggctgg gaccccagag gggacccagg aaggtgggga     1620

gagctgcagc tggggagact gcagggcaag ctgctccaaa gctggctttg ctttccagac     1680

caaggttggg atccaaatgc gaatctgaga aaactgctcc caggaatcaa atagtggaag     1740

g                                                                     1741


<210> 1223
<211> 4064
<212> DNA
<213> Homo sapiens

<400> 1223
gaggcctgcg cgtgcggtct gcagttcggc cgcttcctct tggcgggtgg gctgcagcta       60

tggagggcga gcctccacct gtggaggagc ggcggcggct gcaggaggag ctgaacgagt      120

tcgtggagag cggctgccgg acgttggagg aggtgaccgc gtccctgggc tgggacctag      180

atagtctgga tcccggggaa gaggaggcgg cggaggatga agttgtgata tgtccatacg      240

attccaatca tcacatgcct aaatcatctt tggcaaagca catggcatct tgtagattga      300

ggaaaatggg ctataccaaa gaagaagagg atgaaatgta taatcctgag tttttctatg      360

aaaatgtgaa gataccttcg attactttga ataaggactc acaattccag ataattaaac      420

aagctagaac tgcagttggg aaagacagtg attgttataa tcaaagaatt tattcttcat      480

tgcctgttga agttcctttg aatcacaaac ggtttgtttg tgatctaact caagctgatc      540

gtcttgccct ctatgatttc gtagttgagg agacaaagaa aaagcgctct gattctcaaa      600

ttattgaaaa tgacagcgat ctctttgtag acttggctgc caaaatcaat caagacaata      660

gtcgaaaaag tccaaaatcc taccttgaaa tcctggcaga agtacgagat tataaaagaa      720

gacgccagtc ctatagagcc aagaatgttc acataaccaa gaaatcatat actgaggtga      780

ttcgagatgt gataaatgtg cacatggaag aactcagcaa tcattggcaa gaagagcaag      840

agaaggcaga ggatgatgcc gaaaagaatg aagaaaggcg atcagcttca gtagattcac      900

ggcagtctgg tggaagctat ttggatgctg agtgttcacg acatagaagg gataggagta      960

gaagcccaca taaaagaaaa agaaacaaag ataaggataa aaactgtgag tcgagaagaa     1020

ggaaagagag ggatggggaa agacaccata gtcataaaag aagaaagcaa aaaatataaa     1080

tgaagtactt gtacctatat taattatgct tacgccatga taaccaatat acagatatat     1140

taattggaat tcctttgcat aggagaatgt ttttatgatc tgtttagtgc ttattatttt     1200

ttttatgatc tgtttagtgc ttattatttt ccagtaaata tgcttcaaac catgagtaca     1260

ctattaggcc ctacaacttt gttttcctta tattttatta gatgatttgc ttcctataac     1320

tgatgttgtt ttgttcgttt tgctaatata tgtatctcaa aattctttaa gtcaatattt     1380

atcatatgta aattaaacat gaatacattc tcatcttata actacatctt ataaataagg     1440

ctaataaccc ttagaacacc acctgcggtt ctgtcctcac cccagtggtg actactgttt     1500

accactacac tggtgaattg tagtagggaa aaacaatcta aatattgaag aggaatggcc     1560

taattaaaat atgatgtagt cataggatag attattgtat tggagttaaa agaaataatc     1620

tagatccata ttaacctgga ttggtctcaa aaacataatg ctcagtgaaa atagcaagtt     1680

gtagaaagtt atatacaaat tatatatatg tacaaaacaa tactatgcat tctctatggc     1740

tatataatgt acgtaaatct atttttaaag gttcagagga atccatacca aagttctaac     1800

agcgagtagg aggtatagat gagagattag gggtgcaaat caggattggg agggtggtca     1860

gagggaactt tagctttatc cataacatta atttttttaa aaaataaggt cttaatgttt     1920

catttaattt aaaatatact gtcatgttgt gttttgtaaa tcaactgaat tgaggtacta     1980

tttacttaga tttattgcac cctttttacg tgtgtatttt attgggtttt gacagattca     2040

tacctctgtg cagccactat cacgatcaag atacaaatat tttcattgcc cccaaaattc     2100

tcataccccc tttcccaatc aattcctcta cccctagccc taggcagcca cagatttgct     2160

tttggttacc gattagatct atccattgta gaattcatgt aaatagaata ctgtagtatg     2220

tactttgcct tcttcctctc tgcagatttt tgagattgat ccctgtgtgt cagttgtgca     2280

ttttttttgt tgctgagtag tatgttctat cttatgtcag atcattcacg tgagactttg     2340

gcatgaaatg ttaagcatcc gacatctaaa tagcaatatt ttgaatactg gaaactcagg     2400

ttaaagattt tgtttccaag tagaaatgaa atcttattat tttaataagt agctgacagt     2460

gacagaaaga ttggatttgg atcagattgg ctgttaggct tcaggtatgg gaaacagctc     2520

tcagatttat aaattggaaa tcaccaggtt acttgccaat atatagtcat attgctgcca     2580

ttgtacttaa tttctaaata tataaaatcc acatttaaaa attataaaag caaggacttg     2640

ggagtgactg atgaatcatg aaattgctgc ttttatagat caaaactact tgaatcatca     2700

ggaatttcat atttttcata ttgtgtgaca acttataatt ttgtttcaaa ttgtgatttc     2760

attgatttta ctaactggaa ggaagaagag taaaattggc atatttaggt tttttgtaga     2820

agaaagatac aagtgaaaat taggagtgga ttggagaaat tggggggaaa tagaagagta     2880

cggagaaagg aagagattga aaatgttacc agagttcttt aaagctcaca ttttatagta     2940

tcactgctac aaactattta atgaaatgtg gcatcgggtg aaaagaggca tttgtttgat     3000

ccttgaacga attaatctca cgtacttccc tgtttgtggt ttgagccttt cactggatgt     3060

gagctacttg agagcagggt ttatgccttc atcagcgtga cccctgtgcc tgcagcctca     3120

taggtgttaa tctgtaattt taaattttga caaaagcatt ttcacagccc tgccacataa     3180

gatctagttt ttatttctag agtgctgcta tgaataatta ctatagctgc tgtccatctt     3240

gcccatccat taaggtacct tctcacaaac atttctaatc tactggctgg agtgcagtgg     3300

tgcagtctgt agctcactgc agcctcaaac tcctaggctc aggcgatcct cttgccctgg     3360

cctcccatgt agctgcaact ataggtgtgt gccactacac ctggctaatg tttttagttt     3420

tttagagatg gagtcttgct ctgttgccta ggctggtctt gaactcctgg gctcagatga     3480

tcctcctgtc ctcagcctcc caaaatgctg ggagccacca ggcaccaggt gtgatctacc     3540

acacctgtct aaaaagtatg tatttttaaa tttttttgta gagacaggat ctcactatgt     3600

tctccagctg gtctcaagct cctggcctcg gcctcctaaa gtgctgggat tacaagtgtg     3660

agccactgtg cctagtcact ttaattgaga tattggcaag tcaactgcca tgcagagccc     3720

agggcactgg ttatattcag taggaaactg aactcagcac tcagaatttt aaattaaatc     3780

aatgatcttc aagtatttgc cactttcgag tacagctaat tggataatct caaacccttt     3840

agtgaaaata tcttaaatgc attgagaata ttttctaatt acctgtgtat gctacagtac     3900

agacattaat tctataaaca tgttcatagg tcttccccct cgccccgccc gtcttctaag     3960

ggcattttct gtttcttttt agtgagttca tgaatgttta acggttctgg cgcaaagctt     4020

tcttgcattc tgagcataaa aataataaaa cccacttata tttg                      4064


<210> 1224
<211> 12929
<212> DNA
<213> Homo sapiens

<400> 1224
cgccagcccg gtcaggcctc ggcgcggcct acacgctccg ctcgctcgct cgctcccgcc       60

tcccgccccg cgcccggcca tggcggagcc gtcgtccgcc cgacgcccgg tgcctctcat      120

cgagtcggag ctgtacttcc ttatcgcccg gtacctatcg gcgggcccgt gtcggagagc      180

ggcccaggtg ctggtgcagg agctggagca gtaccagttg ttgccgaaga gattggactg      240

ggagggcaac gagcacaaca ggagctacga ggagttggtc ttgtccaata agcatgtggc      300

tcctgatcat cttttgcaaa tctgccagcg catcggtcct atgttggata aagaaattcc      360

acccagtatt tcaagagtca cttctttact tggtgcagga aggcagtctt tgctacgtac      420

agcaaaagac tgcaggcaca cagtttggaa gggctctgcc tttgctgctc ttcatagagg      480

aagacctcct gaaatgccag tgaattatgg ttccccacca aatcttgtgg agatacatcg      540

aggaaaacaa ctcacagggt gttccacttt tagtacagca tttccaggaa ctatgtatca      600

gcatataaaa atgcacagaa ggattctcgg acatctatct gctgtttact gtgtagcatt      660

tgataggaca ggacatagaa tctttacagg ttcagatgac tgtttggtaa agatttggtc      720

aacacataat ggccgcttgt tatctacatt aagaggtcat tctgcagaaa tttcagatat      780

ggcagtaaac tatgagaata caatgattgc tgcggggagc tgtgataaaa ttattagagt      840

gtggtgcttg agaacttgtg ccccagttgc tgtgctccaa ggacacacag gatcaattac      900

atctttacag tttagcccga tggccaaagg ctctcaaaga tacatggttt ccactggtgc      960

tgatgggaca gtttgctttt ggcaatggga tttagaatcc ttaaaattta gcccacgtcc     1020

cctgaagttc actgaaaagc ctaggccagg cgttcaaatg ctttgttctt cttttagtgt     1080

tggtggtatg tttttagcca caggtagtac tgatcatgta atcagaatgt attttttggg     1140

ttttgaagca cccgaaaaaa tcgcagaact tgaaagccac actgataaag tagatagtat     1200

ccaattttgt aacaatggtg atcggttcct aagtggtagc agagatggaa cagcacggat     1260

ttggagattt gagcagttag aatggaggag cattttattg gatatggcta ccagaatctc     1320

aggggactta tcttccgaag aggaaaggtt tatgaaacct aaagtaacaa tgatagcttg     1380

gaatcaaaat gatagcattg ttgtcacagc tgtgaatgat catgtcctca aagtgtggaa     1440

ttcttacact ggacaactgc ttcataactt aatgggacat gctgatgaag tatttgttct     1500

ggagacacat ccctttgatt ccagaattat gttatctgca ggacatgatg gcagcatatt     1560

tatatgggat attacaaaag gtaccaagat gaaacattat tttaatatga ttgaaggaca     1620

aggacatgga gctgtgtttg actgtaagtt ttcacaggat ggacagcatt ttgcctgtac     1680

agattctcat gggcaccttc tgatatttgg ttttggatgc agcaaaccat atgaaaagat     1740

tcctgatcag atgttcttcc atactgacta tcgaccactt attagagatt ctaataatta     1800

tgtcttagat gagcaaactc agcaggctcc tcatcttatg cctccaccat tcttggtaga     1860

tgtagatgga aatcctcatc caaccaagta tcagagatta gtaccaggcc gagaaaattc     1920

tgcagatgaa catttgattc cacagctggg ctatgtggca acaagtgatg gagaggtgat     1980

tgaacaaatt ataagcctgc aaaccaatga taatgatgaa cgcagcccag aatcgagtat     2040

tcttgatgga atgataagac agttgcagca gcagcaagat cagagaatgg gagcagatca     2100

ggatactatt ccaagaggac tttcaaatgg tgaagaaaca ccccggagag gttttagaag     2160

gctgagctta gacattcagt cccctccaaa tattggtctg cgtcgtagtg gacaagttga     2220

aggtgttcgt cagatgcatc aaaacgctcc acgcagtcag attgctacag aacgtgacct     2280

gcaggcttgg aaacgaagag tggttgtacc agaggtacca ctaggcatat ttaggaagct     2340

ggaagacttc cgattagaga aaggtgaaga ggaaagaaat ctttatataa taggaagaaa     2400

aagaaagact cttcagctct cacataagtc ggattcagtg gttttggtat cacagtctag     2460

acaaaggaca tgtaggcgta aatatccaaa ttatggtaga agaaatcgta gctggcgtga     2520

gttatcttct ggaaatgagt cttcaagctc tgtaagacat gagacttcct gtgatcagag     2580

tgaaggttct ggttcttcag aagaggatga atggagaagt gacagaaaaa gtgagagtta     2640

cagcgaaagt tcaagtgact cttcatctag atattccgat tggacagctg atgcgggcat     2700

caatttgcag cctcctttaa gaacatcatg tcgtcgacga attactcgat tttgtagtag     2760

ttcagaagat gaaatatcta ctgagaattt atctcctcca aaaagaagac gaaagagaaa     2820

gaaagaaaat aagcctaaga aggagaattt gcggaggatg actccagcag agcttgcaaa     2880

tatggagcat ttatatgaat ttcaccctcc agtttggatt actgacacca cacttagaaa     2940

atctcctttt gttcctcaaa tgggtgatga ggtaatatat tttcgacagg gtcatgaagc     3000

ttatattgag gctgtaagaa gaaataatat ttatgaactg aaccctaata aggagccatg     3060

gagaaaaatg gatcttaggg atcaagaatt ggttaaaata gttggaatac gatatgaagt     3120

tgggccccct acactctgtt gcctaaaact agcatttata gatccagcaa ctggaaaact     3180

tatggacaaa tctttctcta ttagatatca tgatatgcca gatgttattg actttcttgt     3240

attgcgtcaa ttttatgatg aagcaagaca gaggaattgg cagtcttgtg acagattccg     3300

ctctattatt gatgatgctt ggtggtttgg aacagtgtta agtcaagagc catatcaacc     3360

acagtatcct gatagtcatt tccagtgtta tattgttagg tgggataata ctgaaattga     3420

aaaacttagc ccatgggaca tggaaccaat tcctgataat gttgatccac ctgaagaatt     3480

aggagctagt atttctgtca caacagatga gctagagaaa ttgctctata aaccacaagc     3540

tggtgaatgg ggtcagaaat caagagatga agaatgtgat agaattatca gtggtataga     3600

tcaacttttg aatcttgata tagcagcagc ttttgcaggc cctgttgatt tgtgtacata     3660

cccgaagtac tgtactgtag tagcttatcc aaccgatctt tacacaattc gaatgagact     3720

tgttaatcga ttttacagga ggctgtctgc gttagtttgg gaagtcagat atatagaaca     3780

taatgccaga acatttaacg aacctgagag tgtaattgca agatcagcta aaaagataac     3840

tgaccaactt ttaaaattta tcaagaatca acactgtaca aatatctcag aactttctaa     3900

cacatctgaa aatgatgagc aaaatgctga ggatttggat gatagtgatc ttcctaaaac     3960

atcttctgga aggaggagag tccatgatgg gaaaaaaagc atcagagcta cgaactatgt     4020

tgaaagcaac tggaagaaac agtgtaagga actagtgaac ttaatttttc agtgtgaaga     4080

ttctgaacca tttagacaac ctgttgattt ggttgaatat ccagactaca gagatattat     4140

agatacccca atggattttg gaacagtaag ggaaactcta gatgcgggaa attatgacag     4200

ccctttggag ttttgcaaag acatccggct gatatttagc aatgcaaaag cgtatacacc     4260

aaacaaaaga tcaaagattt atagtatgac cttgagatta tctgccttat ttgaagaaaa     4320

aatgaagaaa atctcttctg attttaaaat tggtcaaaaa ttcaatgaaa aacttcgaag     4380

aagccagagg ttcaagcaac ggcaaaattg taaaggtgac agtcagccta acaaaagtat     4440

cagaaacctc aagccgaaga ggttaaaatc tcagacaaaa ataattcctg agttggtagg     4500

ttctcctacc cagtctacct caagtaggac agcttatctt ggaacccaca agacaagtgc     4560

tggtatctct tcaggtgtta cttctggtga ctcttcagat tcagcagaat catcagaaag     4620

gaggaaaaga aatagaccta taacaaatgg ttctacatta tctgaaagtg aagtggaaga     4680

ttctttagct acctctttgt catcgtcagc ttccagtagt tctgaggaaa gcaaagagag     4740

ttccagagct cgtgaatcct cctcacgcag tgggctatcc agaagcagca atctcagggt     4800

aaccagaact agagctgctc aaagaaaaac tggtcccgtt tcattagcaa atggatgtgg     4860

cagaaaagcc actcgaaaga gagtctattt aagtgattct gataacaatt cattggagac     4920

tggtgaaatt ctaaaagcca gagctggaaa taaccgaaaa gtcttaagga agtgtgctgc     4980

tgtggctgcc aataaaataa agctaatgag tgatgtagaa gagaattcta gctctgaaag     5040

tgtctgttct ggtcggaagc tgcctcaccg caatgcttct gctgtagcta gaaaaaagtt     5100

attacataat tctgaagatg aacagagctt aaagtcagaa attgaagaag aggagctaaa     5160

agatgaaaat caactattac cagtgtccag ttctcacact gcccagagca atgttgatga     5220

atctgaaaac agagactcag agtcagaaag tgatttgcgg gtagcccgga aaaattggca     5280

tgctaatggt tacaagtccc atactccagc accttcaaag acaaaatttc ttaaaataga     5340

gtcttctgag gaagactcta aaagtcatga ttcagatcat gcatgtaaca gaactgctgg     5400

cccatcaacg tctgtgcaga aacttaaggc agagagcatc tcagaggaag cagattctga     5460

accaggaaga tctggtggta ggaaatacaa tacatttcac aagaatgcga gtttctttaa     5520

aaaaaccaag attctgagtg actcagaaga ctctgaatct gaagagcaag atagagaaga     5580

tgggaaatgt cataaaatgg aaatgaaccc aatttcagga aatctgaact gtgaccctat     5640

tgctatgtcc cagtgttcct cagatcatgg atgtgaaact gatttagatt cagatgatga     5700

caaaatagaa aaaccaaaca attttatgaa agattctgca tcacaagaca atggactaag     5760

cagaaaaatt tccaggaaaa gggtctgttc cagtgactca gacagtagtt tacaggtggt     5820

taagaaatca tcaaaagcca gaacaggtct cctgaggatt actcgaagat gtgcagctac     5880

ggctgccaat aagatcaagc tcatgagtga tgtagaagat gtcagtttag aaaatgtgca     5940

cactagaagc aaaaatggaa ggaaaaaacc tctccatctt gcttgtacta cagctaagaa     6000

gaaattgagt gattgtgaag gaagtgtaca ttgtgaagta ccaagtgaac agtatgcctg     6060

tgaaggcaag ccacctgatc ctgactccga aggtagtaca aaagtgctta gtcaggctct     6120

aaatggagac tcagactctg aagatatgtt gaattcagaa cacaagcaca ggcataccaa     6180

tattcacaaa atagatgcac cttctaaaag aaaaagttcc tctgttacat cttcaggaga     6240

agattcaaaa agtcatattc cagggagtga gactgatagg acattttctt cagagtcaac     6300

cttggcacaa aaagctactg cagagaataa ttttgaagtg gaactgaatt atgggctgcg     6360

caggtggaat ggcagaagac tcaggaccta tggaaaggct ccttttagta agacaaaagt     6420

gattcatgat tcacaggaaa cagcagagaa ggaagtaaaa aggaagagat cgcatcctga     6480

attggaaaat gtgaaaatct ctgaaacaac tgggaattca aagtttagac ctgatactag     6540

ttccaaatca tcagatttgg gatctgtaac tgaatcagat attgactgta ctgataatac     6600

aaaaaccaaa aggaggaaaa cgaaaggaaa agcaaaagta gttagaaaag gtaaaacttt     6660

tacagctaac atatctaaaa ctgtgagacg tcaaagacaa agcaaacgcc ctaggttaag     6720

tgtggatgat aatgactggg aggatttgga ctatgcaaaa tctaaaagag ttcttcgacg     6780

ttcaaaaata aaaacgagaa atcagggtag aaggactgtg agataccatg atggggatga     6840

tgacagaagt ttagaaaatg tgttagattt caatggttgc accttatgac cttgagggaa     6900

agccagttca tttaagagga aatggactgg catttatggt gaaagctggc tgttaaaatt     6960

atttttttgt cttacaattc agggaatata tttatatttt tctatgaaaa gttatgaatg     7020

tgactaaatc atgactgtta tttttatttg cacttgctgg tctttgtagc agcattcagc     7080

acaggtgcca aaatatgctt cattttgggg gcagatctat tttgacagta tttgactaca     7140

tatagcaaga gtttgaaata tgttaaacac tagacatcct ggttatcaaa accaatgagc     7200

attactttca tggcagcaag tgtcatgcag ttattttctg aatttgtcaa agaggcagta     7260

gtttctaacc cctgttctat agtagttaca acaatttcac aacctatgtt tacagattct     7320

tcataaatac atgcatactg acactataat catgggaggt gtaaccatga ttagtaggcg     7380

aggtacctac cacttttttt tttttcttcc cctggctact tgagtagaat gcattatacc     7440

agatctggtc actttcattg aaatggtttc taattttctt cccaagtgct gttgggtttt     7500

tttcttctta aggaaaacgt tgtcactttt atgttataaa cttgaattta taaagtgctg     7560

gtaaattatt tttaatgatt tgagtgcatg ttttaaacct ctaggaccag agcatagtca     7620

gagcattttc ttttaaattg tgcactaaca aaatgctata taatctgtct tctgtccaag     7680

atctcctggt ttccattgta agggatttaa ccaaaatctt gctcttccat aatcttactc     7740

tgtgaaatag aggaattcgt gtgccttaga tttagaagtg tgttctttaa tagagtgtac     7800

agggctaaaa gagtatttaa gttaatatgt aggtttcccc catctgtatt ccaattgtag     7860

aggtgagttt tgttaagagt acaattgcaa atcttatcta tataggaaaa tagctaaatg     7920

tcattctcca tctctttgtt ttagtttact gcttccatgt gcaatcctaa gcattctttg     7980

ctggggcaac taaatgtatc tttattagtg acttctagtc caaatataag aaactgtcat     8040

gttttgtggg aaaataattt tataatccat ttaaagtgaa agtttatcac acaaatagta     8100

cacttatttt ctaaccaaat acttgatagg ttatgctact ccagtgtaga tggccattcc     8160

taacttgttt gtgcctgaag atggacttga ttcaaatggt ttacatattt agtgggtaag     8220

ggatatgtta cagtacccca cctgtaagtt atttattagc cctaattgtg tttgatttca     8280

gacaaaatta acccttttct cctgtgtatc tttgaagtgg cagataaggt gaagcatcag     8340

actggtatca atattagaca atgttattta ttagccctaa ttgtgtttgg tttcagacaa     8400

aaccttttct cctgtgtatc tttgaagtgg cagacaaggc gaagcatcag actggtatta     8460

atgttagaga atgttctgaa gtgttcctat tttgtagtta tctattccat ttgacatagt     8520

agaaggtaca ttttctttct actctgatgc atggggaagg atgtttttgg acattatcaa     8580

ctgagatagg tgggaaacct cctctcattt gtggcttaga gagctatcac catttcagaa     8640

ctatgatgct tttcttctca gaacttgtgt taagtagata gtaaacagat tgattcatga     8700

taattgtcct tgactaagac tgaaaagact aatgggatgc cttttacttt gctaatttta     8760

aaaactggtg atagatgtca aatccattaa tttatttaaa ctcttcttaa ccttctcttt     8820

tataatctgt tctcaggttt taactccatg tttaccatca tttgcaaaaa ggtaccaaaa     8880

aaatccataa ataaatatgg aatacattca taagtacata cattcttttg gtataaaaca     8940

atattttgac agtttaggct tcattaatag aactattctg attatttgga ctgcattaat     9000

tggtcattga ctggccatcc aattaccatt ttttctttca gtccaaaata gttagaccct     9060

tgcatacaga agtggtattt tggtttttaa tcagatttgg tttcatcaga agcagcaaga     9120

atggacctga tgtctttaaa agcatagccg acaatggtag cttctcaagt tatgaaataa     9180

aactgagaga taatggagaa aataattttt atgggttttt ttggttatgg tgctattcct     9240

aaggttaact ttgaatatgt gacacacaca ctcctaagta cctttaagga aaattaataa     9300

atcattaata gttaaaatgt ttacattgag cactagaaca tgtttggcct tttttttcta     9360

cgttatgcaa aatgcccagg gatttaatgc acaggtgtac tttaatgttt agggtcagtt     9420

tgtagtattc ttgagaaaaa gataaagggt tataatttga atgtgaactg atccagaaat     9480

aagtgctgta cctttccact gcacttgaag ttcaacttaa tggtgtatgt gaaaaacaaa     9540

aactactttg gttgtgtatg tccaaagtcc tatggtttta ttcatttatg gttttacagg     9600

ctttgaagta ctcagatttg atttttgctt tcttggaaag actcacttta ccaagcatat     9660

aaaggaaaaa tgatttcaaa cattgacaag atagatgagt gttaacaaag ctttcttttt     9720

tcgtgtcctc cttatttaaa aaggtatact tacaatgtga agtaacttat gaataaaagg     9780

aaaagtttat cccatattca aataattcct aaggtcagcc tccctttttg taagtggcaa     9840

atatctgatt aaatcatttc tcagtttatt aatccttgga aacaatgata tagcagttac     9900

tcacagcttg taaattacaa cagaaaggtt cctttcaaat agtagagctg cacctaaaga     9960

ggaaattggg tttataagaa aatggaggca aagaacttaa gttttaagaa aaagcacttc    10020

aaaacagaag ggcaaatgga aaaggggaat ataaaacaaa ccaataaaaa taccatctga    10080

gggtgttact gtccaaaagt aaagaataag atgcatcact aagccctttg cactcgttat    10140

gacctcgtaa gtaaaaatta tcacttagaa taaggggtgc acactacatt ccctctgtct    10200

tctagacttt tttttttgta gaagaatcag aaaacaattt actaacctcc ctgtttgata    10260

ttaaaaatag gaagaatttt aatattttct gttagtacaa gttgaacttg attgtgccaa    10320

ctgaaacccc agaggtttgt atatcagtag aatgcaagaa cattgttaaa ggtgcttacg    10380

atcttttttg ttttcctttc cactccattg tatcaatttt ttgagtaact tttaaatggc    10440

tagaaaatgg tctttttgct ttgccctttt aaagctgaaa taaccagctc cattcttttc    10500

atgaatagta agttgatata tttatttatc aggtatcttg cagttgtcac caaatactgt    10560

agttttctta tgttgtatgg aaattatagt tcaattattt taatgtgata gagtgcaaca    10620

agtcattgta gaacttttca cctgttaatg ttgaagttat acctctgaat ttctgctgtg    10680

gatatcaagg aaataataaa gcagaaaccc caagaaattt gcaacttaac agtttgagac    10740

tgtctcttat cctagtattt gggaagagaa ggaataaatt tgtcaaaact aggtgagaaa    10800

atagagcatt gtgggaaaaa ctgagtccaa ctagattagc aaatgttaat tcctagctca    10860

aactgtgaat agtaaggatt gaaaagtaaa gtatgtaatg ctaagggctg tgttgtcttt    10920

tcttacgatt ttaagtttta aaggctgtta aattacagag atgttgccca aggatacatg    10980

gggattctca aaagtaagag atttttacct ttttcataat ctgccaagct ggttcctaat    11040

atattgttaa attggtagaa aaatatcttt aaattggtgt ctgctcaaga attgcttttc    11100

tagatttgat ggagggaggg ggagagtcac atcatttgga ttctaccaat ctgcaggctc    11160

tatctttggc aacatgtaaa taattagact atacatctgt ttctcaagta tggcaagacc    11220

aatagtttga atttaattat caatgctatg gtatactttc tggtcatatt ttagttatgt    11280

cagttttaag gtaagttttt tcatttatta aagcccttaa atgagatttt agactgccaa    11340

agagaagagg cagtccaatt gacctaactg aaatgagatg accagtatat agagcctaga    11400

tggactgtag cagctctacc cctttgtttt acaaggtaaa tcattttaaa aattaccttt    11460

tttgatcagt gggtaaaagt taaagggatc tttaattttt gatatattca agttaatttt    11520

ctaaatgtga atcagtcctt ggactgcaac tatatattca cctacaaaat cccaatcaaa    11580

aaattacatg agcctgtcaa gcagatcttt agttttccac ttcacataag atcgttaatg    11640

ttctaaatta atctattcat ttagatgatt tttgtcagtt cttaaatggg atataataaa    11700

tttagcattt tcatcttaac aagcaaaaga gttaaaaaac aaaacaaaac actactccaa    11760

gccaaataca ttctagctgg ttaattccag acttgtccca agtggttccc caacctcttt    11820

tccactggta atttcttttc atgcaggcag aatatagggg tgcgagcgct gtgagtttta    11880

catatgagct tggatagggg aactgaagcg agtcaggagc cctgctggaa aaggggtttg    11940

ccattggatt gtctgtggcc tggtttcttt ccagtagtac agtaataggg tagattgaaa    12000

acaagtattt acttctgatt ctgcctgcat ttagtgtgaa atgctcttaa ggtattgctt    12060

ctaaaaagca aattaagcag ttaagtataa agtccctgaa ttcatatttc aaaataaggc    12120

ttttatgaga tttttattaa aaattgcaat agccatcaca aatctgagtt tttctagggg    12180

tgagagaaaa ctgtattgtg atgagctaga ttagttgtag ttccagaata agaacaaaaa    12240

ttcagagttg tgtggtgccc atcattgagt aaatgaaccc taaaaatgaa taagctaatg    12300

aactagttca tggaattatt tctgatggtc ttttgacctg atgctgccat actgcagtgt    12360

taccagctcc ccctagaaaa cggaactgtt taaaaacaca gcaagttaca gaaaccattt    12420

tattctacag ccattggggt acttcagttt atgggatgtt tttggaaact tctgctttgg    12480

gagggatgaa gatcattgat aaatgttatt tgctttctga gttttggggt catttcattg    12540

cttatcaatg aagggcagac agaggagaga atatctcaag tcttttctga taaaaggctt    12600

gcttgaggga gcttataact tgcacctaga gggtttaccc actttgtgga tttgatttat    12660

ccaccaacca cagcaaccaa taatgtcaag attctaggag tttatgaaag aggctagtat    12720

gttttcattt tgagtcagac attcttttct cattctcaaa tctgttttaa atgctccaat    12780

tttaaaaatg ccaatgaaaa ttttataatg cttctgtagt aaccatatgc agtttacttt    12840

gaatttagga aaacagtttt gtatgatgaa atattgtgca gaatctgtaa ataaggtagc    12900

ttaaaaatta aaaaaaagtc taattagaa                                      12929


<210> 1225
<211> 1157
<212> DNA
<213> Homo sapiens

<400> 1225
acatgcgcac agagcccggg cggctacgga agcggtgaga ctgtctctcg gctgcagccc       60

tggtgcgacc cggcccgttg ccgtagagat gggcagggct ggatggagtg gggtgcggtg      120

agctgagctg accctgcttc gccacgggga ctgcagtgac cccggcttgc cggcagggcg      180

ggtaacaggt tgagccaggg tggggctgct caggggcgtg gagccgaggc caggatttct      240

ctgaagaccc ggcacaggct attcctttct gcgacgagcc cattgctatg gaaaccaaag      300

cgttaggcca gcggggattg aggctgcggg atcatgacgg gtctctctcc cgaagaacct      360

tgcctaaggc ttccccaagc ggctacttcc tgagcgaacc cgcccacccg cctgaaggag      420

agagctttgt ttaagactga gaaagtgagg gtccgagagt ctaatgaatg ctctgggcac      480

ccaggccgca cctgaggagc accgacgact gcacggtctg cggcgcggga agcagatctg      540

cggctgaacc tctaccccaa ttacttagcg gcgactgagc ctatcgagca gttttccatg      600

gacacagcct agcagaaaga cgcagccttc gtgcttcgct gactgctgac cactgaccca      660

ccgccttgat gacagcaccc tcgtgtgcct tcccagttca gttccggcag ccctcagtca      720

gcggcctctc gcagataacc aaaagcctgt atatcagcaa tggtgtggcc gccaacaaca      780

agctcatgct gtctagcaac cagatcacca tggtcatcaa tgtctcagtg gaggtagtga      840

acaccttgta tgaggatatc cagtacatgc aggtacctgt ggctgactcc cctaactcac      900

gtctctgtga cttctttgac cctattgctg accatatcca cagcgtggag atgaagcagg      960

gccgtacttt gctgcactgt gctgctggtg tgagccgctc agctgccctg tgcctcgcct     1020

acctcatgaa gtaccacgcc atgtccctgc tggacgccca cacgtggacc aagtcatgcc     1080

ggcccatcat ccgacccaac agcggctttt gggagcagct catccactat gagttccaat     1140

tgtttggcaa gaacact                                                    1157


<210> 1226
<211> 4039
<212> DNA
<213> Homo sapiens

<400> 1226
gactgtactc ccaggcccag gccagcagct aatgcaagct gcaatgccaa atggtactgt       60

tcagcgattc ctctttaccc cattggcaac aacagccacc acagccagca ccaccaccac      120

cactgtttcc acgacagcag caggtacagg tgaacaaagg cagagtaaac tgtcacccca      180

gatgcaggta catcaagaca aaaccctgcc accagctcag tcatcaagtg tgggtccagc      240

agaagcccag ccacagactg ctcagccttc agctcagccc cagccccaaa cccagcccca      300

gtccccagct cagcctgaag ttcagactca gcctgaagtt cagacccaaa caactgtttc      360

atcccatgtc ccttctgaag cacaacccac ccacgcacag tcatccaagc cccaagttgc      420

agcacagtct cagcctcaaa gtaatgtcca aggacagtct cctgttcgtg tccaaagtcc      480

atcacagact cgaatacgtc catcaactcc atcccaactg tctcctggac aacaatccca      540

ggttcagact acaacctcac aaccgattcc aattcaacca catacatctc ttcagatacc      600

ttcccaaggc cagccacagt cacaacccca ggtggtgatg aagcataatg ctgtaataga      660

acatttaaaa cagaaaaaga gcatgactcc agctgaaaga gaagagaatc aaagaatgat      720

tgtctgtaac caggtgatga agtatatttt ggataagata gataaagaag aaaaacaggc      780

agcaaaaaaa cggaagcgtg aagagagtgt ggagcagaaa cgtagcaagc agaatgccac      840

taagctgtca gctctgctct tcaagcacaa agagcagctc agagccgaga tcctgaagaa      900

gagagcactc ctggacaagg atctgcaaat tgaagtgcag gaagagctga agagagacct      960

gaaaattaag aaagaaaaag acctgatgca gttggctcag gccacagcag tagctgcacc     1020

ctgcccccca gtgacaccag ctcctccagc ccctccagcc cctccacctt cacctccccc     1080

tccacctgct gtgcaacaca caggccttct gtccacgccc accttacctg ctgcttccca     1140

gaagaggaag cgggaagagg aaaaagactc cagctcaaag tccaagaaaa agaaaatgat     1200

ctctactacc tcaaaggaaa ctaagaagga cacaaagctt tactgtatct gtaaaacgcc     1260

ttatgatgaa tctaagttct atattggctg tgatctttgt actaactggt atcatggaga     1320

atgtgttggc atcacagaaa aggaggctaa gaaaatggat gtgtacatct gtaatgattg     1380

taaacgggca caagagggca gcagtgagga attgtactgt atctgcagaa caccttatga     1440

tgagtcacaa ttttatattg gctgtgatcg gtgtcagaat tggtaccatg ggcgctgcgt     1500

tggcatcttg caaagtgagg cagagctcat tgatgagtat gtctgtccac agtgccagtc     1560

aacagaggat gccatgacag tgctcacgcc actaacagag aaggattatg aggggttgaa     1620

gagggtgctc cgttccttac aggcccataa gatggcctgg cctttccttg aaccagtaga     1680

ccctaatgat gcaccagatt attatggtgt tattaaggaa cctatggacc ttgccaccat     1740

ggaagaaaga gtacaaagac gatattatga aaagctgacg gaatttgtgg cagatatgac     1800

caaaattttt gataactgtc gttactacaa tccaagtgac tccccatttt accagtgtgc     1860

agaagttctc gaatcattct ttgtacagaa attgaaaggc ttcaaagcta gcaggtctca     1920

taacaacaaa ctgcagtcta cagcttctta aagttcagcg tgttaaccta acataaaaca     1980

cagcaagaat ctggttgtct gaactatttt aaattaagga gccagatgtt tttagtcagg     2040

ctatcctgac aagacttgac ctaaacttcg tttttattgg tcataacagt ccaattatat     2100

tcttggccaa ttttgtccaa cggacaagaa aaaagcaaag tcaacgacac cattatcttg     2160

tcaagatcag atggttttac tattgtggca gaagcgagaa aactttgttt attgaaaaaa     2220

aaagaaaaag aaagcaagaa aaaaagatac tatggggtca agtgtaactc catggaaatg     2280

ccacgtctgc tcttcagtga agaagctggt ttagagtctc acagaaaact tttgactgta     2340

tttatttatt gttgcaaaaa agacgctttt ttattgctgc cctcatttgt cagctaatta     2400

ttttttctta taaaatccag ccccggttac atataatcat ctgtatctta tcatgattcc     2460

tgtaggtaaa agtacaagac gacctctaga tgtcttttct ttctatgaaa ggagctgcta     2520

tgtacacatg tgcacacaca cacaactggg aatcaacaat gagtttattg ttcatggtag     2580

attaaaatta agcttgcata aaggttgggc taagtggtcc tggactacag actctgttgc     2640

cttgaatata acagtacaat ttgtcaatta ctctgcacca ggctaaaatg agtaaaatct     2700

atttgaaggt atcttgtttg taaacatttg tcagattcta atttttttct tttgtattaa     2760

aattcaacta tggatgtata tgaaacaaaa taaatggaga taatttttct cccacagaca     2820

gaggtgtctt tgaatgtgcg ctaatgatta tctgtaagcc tttgtgggga gggaggcctg     2880

caaggtcatg aaaggcagaa gagtctaatt gtgcctggat ttctccagga cagcagtggc     2940

ccctcgtttt atcattccca gtccattgtc atcacgtcag agaaaaatct tcaggggtgc     3000

taatcctgtt gcatcagttg atcatactaa cgagaacggt aatgcgacaa gatacacatt     3060

gccttcatct gtacattctg tgataccagg caaattacca attacacaca gctacttata     3120

ttttatgaag ggcatttttt agatgacctc atcctctgtg ttatttgttg attgggtttg     3180

ttttctgttt gttggtttgt ttgtttcttc cacgtaagga aaagtagtgt aaacagtagc     3240

gagaaaatgg aaaccacaga ggaagatgta ttttgcatgt ttttcctttc agtgttctta     3300

cacgttgtat cactgcattg tggtaatagc ttctataaaa tctgccatag ttggattatg     3360

cagctttgca aaaattttta ctagattttg cactaactca tattagcttt gtcctaccaa     3420

cttctggaat ttatctaatt attgtttttc aaagtttctt tccttttaat gtttccctgc     3480

tatgcaaaac ctttcccaga cctcagtttc ttaaaagaaa gatgttgcta cagttcccga     3540

ttctttctta ttacaggctc aggtgtacag gttattctgg gttaatttta tctaatgaag     3600

cccattcctt tttgtacata aagatgtcac ttaaacttat gcttacaaac taaagactaa     3660

tcgctcaata tgaaaacatg aaaaaatttt tgcttaaagt attaagatgg aagtagttaa     3720

atatgggtta ttttgtcctt ttactttttt aaaaaatgtt acatattgta tgcactgtgc     3780

tgatgcaaga attctacatt ttaatgagtt ataaaattat tctgcatctc atcacgtcac     3840

agtatttctg tactatttat tcatatatat aaatatatat gggcttaatc atttaaaatt     3900

tgttgcagca agaactttcc tacctgtagg caatagattg ctatgttttt aacaaattgt     3960

ggcaaattct aaacagcaat tcttttgtac gtaataggac atttcatcct agaaaaataa     4020

agtaatgttt ttgacattg                                                  4039


<210> 1227
<211> 1117
<212> DNA
<213> Homo sapiens

<400> 1227
tctccaacga agtcttatat tttaccattc tgcgtgtatt agaaagctaa atttaaacag       60

caacaataag aaatcttccc cagtggatcc ctcgagcctt tcgggaaaat gcaggtttct      120

ggctgacagg aagaagaaac agcatccaat cggcacttgt gtctcaatga ccaatcaaat      180

ttcgccttac attgcatcgc tgggataaac ggagctggac gactcagtct cttggtctgt      240

ggctgctgcg gttacctgga tgggcgagca cctctgaggc tggctttgtt acctgggcaa      300

taagggacta gcagttcagc cgttttctat gcctgctgga tttgtttgta tttgttccca      360

gccactgctc atgtaatgta ctcccttaac caggaaatta aagcattctc ccggaataat      420

ctcaggaagc aatgcaccag ggtgacaacg ctaactggaa agaaaattat agaaacatgg      480

aaagatgcca gaattcatgt tgtggaagaa gtagagccga gcagtggggg tggttgtggt      540

tatgtgcagg accttagctc ggacctgcaa gttggcgtta ttaagccatg gttgctccta      600

gggtcacaag atgctgctca tgatttggat acactgaaaa agaataagga tggagtggtt      660

cttgttcatt gtaatgcagg cgtttccagg gctgctgcaa ttgtaatagg tttcctgatg      720

aattctgaac aaacctcatt taccagtgct ttttctttgg tgaaaaatgc aagaccttcc      780

atatgtccaa attctggctt catggagcag cttcgtacat atcaagaggg caaagaaagc      840

aataagtgtg acagaataca ggagaacagt tcatgagttg cattgtagca gacaatggac      900

aactgtagtt tctgaattga cttctatagc catcttttcc cttttttgga gagtagacta      960

gcaaaactcc cttttttctc ttgccttttt tatgcataaa tggaggtcaa tttgattgtc     1020

ctgacctact gtataagtaa atttcaaatg tcattacttt ctctttgtta ttataatgtg     1080

tgattaaatg cttttttaaa ttgctaaggg aaaataa                              1117


<210> 1228
<211> 2365
<212> DNA
<213> Homo sapiens

<400> 1228
agaccagaaa cggaagagag cgcgggggat gtgtttggcg tggggcgcac tgttcagttg       60

ctctcctgga tggctttatg tctccgcggt gtttcctaga gtctcggcgt ttctacctct      120

tcgcaccctt tcctgccacc ctttgtcccc tggaagcccg gagacatcag cggctgcaat      180

tttgctactc gctgctcggc gtggaactgt caggacaaaa aataatatcc aaagatattt      240

tggcactaac ggcgctatct gtagcaagaa agttgagcag tgtgaactgt tgagacttcc      300

aaggagactt cagacaacca agacagtgta aaggaaaaca gagaaaaaga cttgttagac      360

attattaagg gcacgaaagt tgaattgagc acagtaaatg tacaaacaac aaagccaccc      420

aacagaagtt cacttaaaag ctacaactgg cgggcctcaa agagctttag gacatgctcc      480

aaagaagaga aatgagcccc tgagtcctga gttggtggca gctgcatctg ctgctctgtt      540

ttgacaagca aacaagccag aactgctcag gcagctccgt agcatgagga agagtcaggg      600

gcacagagag atggagagag acctagttag tttcaataac aaaatatcag atatgaaaat      660

tgccagatgt gctacagcta gaattaatat aaggccagag catcagattc agtttgacca      720

aggctatgac aattatcctg gcctggagaa gactgctgat cttagaaaca ggaaaaatat      780

attcaggggg aagagatgta atagatttca cattatggca gttactaaag aagcacgtga      840

acagacacat caccttcact ttgggatatg gaatttgata agcagttagc cacagaatat      900

gaacaacccc ttgagaatga gattgaagaa ctgatccagg ggacaaaaga ggggaaactg      960

agagttccca attaataatg aagcagcttc atatctaaga tctctggtgg actttttctg     1020

cccgtggacg ccgctgaaga agcatcgtta aagtctctct tcaccttgcc gtcatgtcta     1080

agtcagcgtc tccaaaagag cccgaacagc tgaggaagct cttcattgga gggttgagct     1140

ttgaaacaac tgatgagagc ctgaggagcc attttgagca atggggaacg ctcacagact     1200

gtgtggtaat gagagatcca aacaccaagc gctccagggg ctttgggttt gtcacatatg     1260

ccactgtgga ggaggtggat gcagctatga atacaacgcc acacaaggtg gatggaagag     1320

ttgtggaacc aaagagagct gtctccagag aagattctca aagaccaggt gcccacttaa     1380

ctgtgaaaaa gatatttgtt ggtggcatta aagaagacac tgaagaacat cacctaagag     1440

attattttga acagtatgga aaaattgaag taattgaaat catgactgac cgaggcagtg     1500

gcaagaaaag gggctttgcc tttgtaacct ttgacgacca tgactccgtg gataagattg     1560

tcattcagaa ataccatact gtgaagggcc acaactgtga agttagaaaa gccctgccaa     1620

agcaagagat ggctagtgct tcatccagcc aaagaggtcg aaggggttct ggaaactttg     1680

gtggtggtcg tggagatggt ttcggtggga atgacaactt tggtcgtgga ggaaacttca     1740

gtggtcgtgg tggctttggt ggcagctgtg gtggtggtgg atatggtggc agtggggatg     1800

gctataatgg atttggtaat gatggaagca attttggagg tggtggaagc tacaatgatt     1860

ttggcaatta caacaatcag tcttcaaatt ttggacccat gaagggagga aattttggag     1920

gcagaagctc tggcccctat ggcggtggag gccaatactt tgcaaaacca caaaaccaag     1980

gtggctatgg cgtttccagc agcagcagta gctatggcag tggcagaaga ttttaattag     2040

gaaacaaagc ttagcaggag aggagagcca gagaagtgac agggaagcta caggttacaa     2100

cagatttgtg aactcagcca agcacagtgg tggcagggcc tagctgctac aaagaagaca     2160

tgttttagac aaatactcat gtgtatgggc aaaaaactcg aggactgtat ttgtgactaa     2220

ttgtataaca ggttatttta gtttctgttc tgtggaaagt gtaaagcatt ccaacaaagt     2280

gttttaatgt agattttttt ttttgcaccc atgctgttga ttgctaaatg taatagtctg     2340

attgtgacgc tgaataaatg tctct                                           2365


<210> 1229
<211> 752
<212> DNA
<213> Homo sapiens

<400> 1229
gtaccattct tcaagaaacg gtttgaatca gactgccttt ccttttgtct tcattgtcat       60

aaacatctgc ccccgtgtgg ttctgactgg ccgcgaaccc ctacccgaag cttttattcc      120

atcattgtgc accgttggtg gggaatgctg tggcaacagg ccacgcctcc acttactggt      180

tggctttgcg caggcgccaa cggaagtggg tcgcaggaag aggaagtccc gcctctctct      240

cctcaggcag cagcaacgcg gaggaaacgg gagtgaacgg agagcgtagt gaccatcatg      300

agcctcctca acaagcccaa gagtgagatg accccagagg agctgcagaa gcgagaggag      360

gaggaattta acaccggtcc actctctgtg ctcacacagt cagtcaagaa caatacccaa      420

gtgctcatca actgccgcaa caataagaaa ctcctgggcc gcgtgaaggc cttcgatagg      480

cactgcaaca tggtgctgga gaacgtgaag gagatgtgga ctgaggtacc caagagtggc      540

aagggcaaga agaagtccaa gccagtcaac aaagaccgct acatctccaa gatgttcctg      600

cgcggggact cagtcatcgt ggtcctgcgg aacccgctca tcgccggcaa gtaggggccg      660

cctgtctgtt gacagaactc actcctctgt cctatgaaga ccgctgccat tggtgttgag      720

aataataaag ctctgtgttt ttttctagtg gt                                    752


<210> 1230
<211> 3118
<212> DNA
<213> Homo sapiens

<400> 1230
cgcagaagaa ccacaaaccc cagaagccct cgcgcccact cttctccctc ccctccagaa       60

gtcggagtgc tgtttttgtt gttggtgaaa ggtgagggga acagctgatc cgtctgttgg      120

gaggacagat atctcaaggc caggatggaa gaatcaccac taagccgggc accatcccgt      180

ggtggagtca actttctcaa tgtagcccgg acctacatcc ccaacaccaa ggtggaatgt      240

cactacaccc ttcccccagg caccatgccc agtgccagtg actggattgg catcttcaag      300

gtggaggctg cctgtgttcg ggattaccac acatttgtgt ggtcttccgt gcctgaaagt      360

acaactgatg gttcccccat tcacaccagt gtccagttcc aagccagcta cctgcccaaa      420

ccaggagctc agctctacca gttccgatat gtgaaccgcc agggccaggt gtgtgggcag      480

agcccccctt tccagttccg agagccaagg cccatggatg aactggtgac cctggaggag      540

gctgatgggg gctctgacat cctgctggtt gtccccaagg caactgtgtt acagaaccag      600

ctcgatgaga gccagcaaga acggaatgac ctgatgcagc tgaagctaca gctggaggga      660

caggtgacag agctgaggag ccgagtgcag gagctcgaga gggctctggc aactgccagg      720

caggagcaca cggagctgat ggaacagtac aaggggattt cccggtccca tggggagatc      780

acagaagaga gggacatcct gagccggcaa cagggagacc atgtggcacg catcctggag      840

ctagaggatg acatccagac catcagtgag aaagtgctga cgaaggaagt ggagctggac      900

aggcttagag acacagtgaa ggccctgact cgggaacaag agaagctcct tgggcaactg      960

aaagaagtac aagcagacaa ggagcaaagt gaggctgagc tccaagtggc acaacaggag     1020

aaccatcact taaatttgga cctgaaggag gcgaagagct ggcaagagga gcagagtgct     1080

caggctcagc gactgaaaga caaggtggcc cagatgaagg acaccctagg ccaggcccag     1140

cagcgggtgg ccgagctgga gcccttgaag gagcagcttc gaggggccca ggagcttgca     1200

gcctcaagcc agcagaaagc cacccttctt ggggaggagt tggccagtgc agcagcagcc     1260

agggaccgca ccatagccga actacaccgc agccgcctgg aagtggctga agttaacggc     1320

aggctggctg agctcggttt gcacttgaag gaagaaaaat gccaatggag caaggagcgg     1380

gcagggctgc tgcagagtgt ggaggcagag aaggacaaga tcctgaagct gagtgcagag     1440

atacttcgat tggagaaggc agttcaggag gagaggaccc aaaaccaagt gttcaagact     1500

gagctggccc gggagaagga ttctagcctg gtacagttgt cagaaagtaa gcgggagctg     1560

acagagctgc ggtcagccct gcgtgtgctc cagaaggaaa aggagcagtt acaggaggag     1620

aaacaggaat tgctagagta catgagaaag ctagaggccc gcctggagaa ggtggcagat     1680

gagaagtgga atgaggatgc caccacagag gatgaggagg ccgctgtggg gctgagctgc     1740

ccggcagctc tgacagactc agaggacgag tccccagaag acatgaggct cccaccctat     1800

ggcctttgtg agcgtggaga cccaggctcc tctcctgctg ggcctcgaga ggcttctccc     1860

cttgttgtca tcagccagcc ggctcccatt tctcctcacc tctctgggcc agctgaggac     1920

agtagctctg actcggaggc tgaagatgag aagtcagtcc tgatggcagc tgtgcagagt     1980

gggggtgagg aggccaactt actgcttcct gaactgggca gtgccttcta tgacatggcc     2040

agcaccatct tctgcagagc ccaaattgcc ctgcttcccc tctctcctgc ctctacccct     2100

tccccaacca ccagtggctt tacagtgggt accctgtcag aaaccagcac tgggggccct     2160

gccaccccca catggaagga gtgtcctatc tgtaaggagc gctttcctgc tgagagtgac     2220

aaggatgccc tggaggacca catggatgga cacttctttt tcagcaccca ggaccccttc     2280

acctttgagt gatcttactc cctcgtacat gcacaaatac acactcatgc acacacacac     2340

tcacacacat gcatacactt aggtttcatg cccattttct atcacactgg gctccatgat     2400

attctgttcc ctaagaactg cttctgtgtg ccctgttttc atcccaagat ttctcacttc     2460

atcctctcct acctggctct tttgtcccag ggaggggtcc tgttcggaag cagtggctga     2520

atttatcccc tgaaagtggt tttggaggaa ccgggatgga ggaggccttc ccctgtggga     2580

atagaatcgt ccactcctag ccctggttgc ttctgataca cagccactgc acacacacac     2640

tcacactcac actcccttgt ctgatgcccc aaagccaatt cctggggcac cctaccctct     2700

cttatttgga gtttccgttg gtttacctga gttttctctg gggtctgcac agaggcagca     2760

gcatggacat catggcctct caggtccctt ttggttctca gtttcattgg ttcctctttc     2820

tgttccccca ttgacttctg tgccccaccc tagccttttc cataacctta ggtattcagt     2880

ttggaggggt tttttgtatt tttgaggatt cctgtattct gtatcctctc ctcgcatctc     2940

ctcacatgga aagaaataat gtatttgtgc cttctgtgag gaatgggggg aacaagtggt     3000

cccaggtatc cccatttcca aggcccccct ccctctccag gtccccccac agcaataaaa     3060

gcttccccct gatatccatc cctttgtagt ttgaacaaat atatttatat gatatgta       3118


<210> 1231
<211> 4401
<212> DNA
<213> Homo sapiens

<400> 1231
ctgcaggtca ttctgctgga cagcaaccct ctgcagagtc cacctgccca ggtctgcctg       60

aaggggaaac ttcacatctt caagtatttg tccacagagg ccgggcagcg tgggtcggcc      120

ctgggggacc tggccccttc tcggcccccg agtttcagtc cctgccctgc agaggatcta      180

tttccgggac atcggtacga tggtgggctg gactcaggct tccacagcgt tgatagtggc      240

agcaagaggt ggtctggaaa tgagtcaaca gatgaatttt cagagctgtc attccggatc      300

tcagagctgg cccgggagcc ccggggaccc agagaacgca aggaggatgg ctcagcggac      360

ggagaccctg tgcagattga cttcatcgac agccatgtcc ccggggagga tgaagagcga      420

ggcactgtgg aggagcagcg accacccgaa ttaagccctg gggcagggga cagggagagg      480

gcaccaagca gcaggcggga ggagccggca ggggaggagc ggcggcgccc ggacaccttg      540

cagctgtggc aggagcggga acggcggcag cagcagcaga gcggggcgtg gggggccccg      600

aggaaggata gcctcttgaa gccagggctc agggctgttg tgggaggggc cgccgccgtg      660

tccactcaag ccatgcacaa cggctcgcct aagtccagtg cctcccaagc aggggctgca      720

gcggggcagg gagcccccgc ccctgcccct gcctcccaag agccccttcc catagctgga      780

ccaggtggga cagggatttt gggaggagga tggggcctgt gttggtgagg gctggttggg      840

agagagggac acagagggga tgcctgtctc acctgcccct gtcgctgtgt ccctggttcc      900

ggccccagcg acagcacctg ctccacggcc acttggctcc attcagagac caaacagctt      960

cctcttccgt tcctcctctc agagtggctc aggcccttcc tcaccagact ctgtcctgag     1020

acctcggcgg tacccccagg ttccagatga gaaggactta atgactcagc tgcgccaggt     1080

ccttgagtcc cggctgcagc ggcccctgcc tgaggacctg gccgaggctc tggccagtgg     1140

ggtcatcctg tgccagctgg ccaaccagct acggccgcgc tccgtgccct tcatccatgt     1200

gccctcccct gctgtgccaa aactcagtgc cctcaaggct cggaagaatg tggagagttt     1260

tctagaagcc tgtcgaaaaa tgggggtgcc tgaggtatgg gggctgcttt ctaaagagtg     1320

gtggcatgcc ggactcagcc gagcatgtgg catggatggt gggcttccat ttgcagcgga     1380

tgtctgctct cagatgaagg cacaggctgc ccctgccctg cccagcatgc cccctgccct     1440

gcatgccccc tgccctgcat gtcacctgtc ctacacatcc cctgccctgc aggccccatc     1500

ttgtcctgca tgtcacctgt cctgcacatg ccctgccctg cactcctcct gcactgcact     1560

ccccctgccc agcacgtcag catgtgggcg tggttctggc cccagcacgt gagggcaggg     1620

gtgggaggga ctgtcctgct gctgctgctg acgtctgtcc cttgtccttg tccacctgct     1680

ctcctctccc ccaggctgac ctgtgctcgc cctcggatct cctccagggc actgcccggg     1740

ggctgcggac cgcgctggag gccgtgaagc gggtgggggg caaggcccta ccgcccctct     1800

ggcccccctc tggtctgggc ggcttcgtcg tcttctacgt ggtcctcatg ctgctgctct     1860

atgtcaccta cactcggctc ctgggttcct aggccccaaa atcggccctc cctcacccct     1920

ttcccttcct ctctatttat aaggtccctg ctccacccga ccccacctgc ggtgccttca     1980

gccccaacca aagacactag tgcaccccct tcacagacac tgacctcaga ggccccactc     2040

tggtgccccc agaccctggg cccccagcct ctggcctccc tccagtagcc ccacgagtcc     2100

ccacctctca gtgctgacgg tgccttcatg tccccgccgg ccctgcccct gccctctgta     2160

ccccgtgagg ggtggcagga gctggagtct cccccttcct cctgtgccct ccccttcccc     2220

ccccaacagc tgctatgggg gggctaaatt atctctattt tgtagagagg atctatattt     2280

gtaggggttc ggggcccagg ccgggtccct atctctgtgt ataaactgta cagaccgtgg     2340

ccgccctgcc tgtgtgtgtg tgtgtgcgcg cgcgcgcgcg tctgctccgc gtgttggtgg     2400

ctgtggccat ggctctgtgc ccaccagcat ctccctcctg agatgccggc ctctcatgct     2460

cccggagcgt ccgccaaccc cccgtgtcac ctcccttctg ttatcgctga cagctttctt     2520

gcgtctcatt tgtcgccgag ccccgagcgc acggtgatgc tcgggtctgc ccccgacccc     2580

ctgccacagg ccggaagccg cagggggcac cgtggggaag ctaacccggc cccttccccc     2640

aggagtcact gtgccagccc caccacatcc tggaagagga gggggccccg ggaaggggcc     2700

tcccctacat cgctgctgtc gtccacgccc tgctggaccg gccttagggg tgaaggtggg     2760

ggcacagggc ccaccccgcc cgggaccccg ggagcagaag acgcgcctgg gctccgcgct     2820

ctcagagaag cacgtggtga gggtggcctg ggcctgggca cccttggcct gccggcctgg     2880

ctgcctctgg ggtcgagggt ctgggtggaa ggaccgcggg tgtcgcaggt gtcgtgtcag     2940

ccgcaataaa cagaagccag aagccctctg ggtggccctc aggtgtaact gtgtctgaga     3000

gcacgtgcgt cgcggggttg ttgggggggc ctctgtttcc ggaattcacc gcccagtcgc     3060

cagggggcgc ccgcgggagc ccggcggggg cacgcgccac gtggccggga gacgcacagg     3120

gcgccagcgt cgccgcgagg cctctggggt gggttcgcca ggagggcacg ttcgcgccgc     3180

gccgcggagg gaggctgaga gggccgggcc gggcggcggg gacacggcgg taccgtcctg     3240

cgctcgggaa cgcggaatgt tgccctggtc gccgccgcgg tggggcgcgg gcccggagga     3300

ggcgcccgag ggaccaggcc ttccggcggg caaggaccag ggcgagccct ggagcgccgg     3360

agcggacgcc cccagggagc tggggacacc cccatgggac aggtgagggg ctcggacgga     3420

gccgtggggg gacagcgact gggggcctcc atgccttcac cacgcgctct acggaggctt     3480

ctccattgtc cctgctggag attgggtccc tcggtctccc ttgcaccagg cacccttggg     3540

ctccagggga gggtgcgtgg gggcggtgtg gctgcagcct cagtccctgc ccctccagcc     3600

cacagccccc atcccgtagc ccttcctgga tctggagaga gcagctgctg ctgccccacc     3660

acctgccagg cccggccact gagcagcccc ccggagcccc agatccccgt tccccccagg     3720

tggcctggga ggtggccccc tcgaggatga ctccactagc gccctgggac cccaagtatg     3780

aagccaaagc aggacctcgg ccggtgtggg gggccaactg tagctcagga gcctcgttct     3840

caggccggac gctgtgtcac ccctcattct ggccgctgta tgaagcagcc tcgggcaggg     3900

gtctcaggcc cgtggcccct gccacagggc actggaatgg acagcaggcg cccccagatg     3960

cagggttccc ggtggtgtgc tgtgaagatg tcttcctctc ggaccctctg ctgccccggg     4020

ggcagcgtgt tcccctgtac ctgtccaagg ccccccagca gatgatgggc tccctgaaac     4080

tgctgccgcc gccccccatc atgtctgcca gggtgctccc ccgcccatca ccctcccggg     4140

gcccctccac tgcctggctc agcgggccgg agctgatcgc tctcactggc ctgctgcaga     4200

tgagccaggg ggagcctagg cccagctcct ccgcggttgg ccccccagac catacctctg     4260

acccacccag cccctgtggt agccccagca gttctcaggg tgctgacctc tctctcccac     4320

agaccccaga cacccattgt ccatagcctt ctcagggcag agtgggctgg ttgtgttgac     4380

aataaaacag tgttggtttg c                                               4401


<210> 1232
<211> 2433
<212> DNA
<213> Homo sapiens

<400> 1232
agtttccaag gtggaagctg ggtccggctg ccaggaagcg gccggtgcgc gggctgcgcg       60

ggctgcgcgg ggctcggctt ccacgtgcga gcctgcaccg ccgccccgcc ctctcctggc      120

ggccaggcct ggggactctc tgccgcggga cggcgcctcg cgttccgccg tggcagtggc      180

cgtggccaga acgtccacgc gcggtcgtcc accgccggat ctcgctccag cgcccgtggt      240

ccagcgtgta gggagccgat cgcccatgga gggtctgggc cgctcgtgcc tgtggctgcg      300

tcgggagctg tcgcccccgc ggccgcggct cctgctcctg gactgccgca gccgcgagct      360

gtacgagtcg gcgcgcatcg gtggggcgct gagcgtggcc ctgccggcgc tcctgctgcg      420

ccgcctgcgg aggggcagcc tgtcggtgcg cgcgctcctg cctgggccgc cgctgcagcc      480

gcccccgcct gcccccgtgc tcctgtacga ccagggcggg ggccggcgcc ggcgcgggga      540

ggccgaggcc gaggccgagg agtgggaggc cgagtcggtg ctgggcaccc tgctgcagaa      600

gctgcgagag gaaggctacc tggcctacta cctccaggga ggcttcagca gattccaggc      660

cgagtgccct cacctgtgtg agaccagcct tgctggccgt gccggctcca gcatggcgcc      720

ggtgcccggt ccagtgcccg tggtggggtt gggcagcctg tgcctgggct ccgactgctc      780

tgatgcggaa tccgaggctg accgcgactc catgagctgt ggcctggatt cggagggtgc      840

cacaccccca ccagtggggc tgcgggcatc cttccctgtc cagatcctgc ccaacctcta      900

tctgggcagt gcccgggatt ccgccaattt ggagagcctg gccaaactgg gcatccgcta      960

catcctcaat gtcaccccca acctcccaaa cttcttcgag aagaatggtg actttcacta     1020

caagcagatc cccatctccg accactggag ccagaacctg tcgcggttct ttccggaggc     1080

cattgagttc attgatgagg ccttgtccca gaactgcggg gtgctcgtcc actgcttggc     1140

gggggtcagc cgttctgtca ccgtcactgt ggcctacctc atgcagaagc tccacctctc     1200

tctcaacgat gcctatgacc tggtcaagag gaagaagtct aacatctccc ccaacttcaa     1260

cttcatgggg cagttgctgg actttgagcg cagcttgcgg ctggaggagc gccactcgca     1320

ggagcagggc agtggggggc aggcatctgc ggcctccaac ccgccctcct tcttcaccac     1380

ccccaccagt gatggcgcct tcgagctggc ccccacctag ggccccgtgg ccggcaggcc     1440

ggcccctgcc ccacccccac ccacgggtgt ccctgcccac tcgtgtggca agggagggga     1500

gggcaggagg gctcggcctg agcagggtgc tggggggaga gcgcaatacc tcacgcgggc     1560

tgccgtccta atcaacgtgc ctatggcggg accacgctcg gagcctgcct cttctgcgac     1620

tgttactttt tctttgcggg atgggggtgg gggttccctc tccaggtggt tgtccaggcc     1680

catgtcccgg ccctgggtgc tcagccagct cggctaggcc ctgcgcctcc ctgcgcttcc     1740

cccttcagga agggtgtgtg ccacctcgtt gcactggatc ccagtggctg cttgggggag     1800

aggcgtttgc catcactggt gttgtcacct ccctgtttct ccaccaaggg cttgggcctc     1860

tcggggctgg ggcctcccag gggatgggga cccagagtgc agtggccgcc cacatccatg     1920

gcctaggagc tactgggcag gttcccggcc acacatctgg tgggctgttt tgtttttttt     1980

ttttcctctt cccccagatg tcttgacggg atcactgggg ctctttgtga gtgagggtgg     2040

ccaaactacc gccggaggag atggggtctc agagcgagag ctgcggaggg ggaggggaag     2100

aagaaggcct cacttttgct gctgcggggc ccacacagcc gctgctactt tggggggtgg     2160

ggaaggggcc aagctgcaga cacacacagt cattcatttc tgtccacacc cctgtgggtg     2220

gcgggtgtgc gtgtgtgtgc ttgtgtgtgc gcacgtgtcg gcgctcacac acacatgcta     2280

gcccactgat gcacccagcc cagggctggc agtctttgca gcgtggggcc gtctcaccct     2340

ggagcctgga gaggatctat gcttgtttgt ttttgtaatc catatcatag ttgctttctt     2400

taattgttcc ttctgaataa acagtttatt taa                                  2433


<210> 1233
<211> 3254
<212> DNA
<213> Homo sapiens

<400> 1233
gcactcggct cggcccggcc cgggccgcag catggccgag ccgctactca ggaaaacctt       60

ctcccgcctg cggggccggg agaaacttcc ccggaaaaag tcggacgcca aggagcgcgg      120

ccacccagcc cagcgcccag agcccagccc tccagagcca gagccccagg ctcccgaagg      180

gtcccaggcc ggagcagagg ggccctccag ccccgaggca tcaaggagcc ctgcacgggg      240

agcctacctg caaagcctgg agcccagtag ccgccgatgg gtgctgggtg gggccaagcc      300

agctgaggac acctctttag ggcctggggt acctggcact ggggagcccg ccggcgagat      360

ctggtacaac cccatccctg aggaagaccc cagacctcca gcacctgagc ccccggggcc      420

acagcctggc tcagctgagt cagagggcct ggccccccaa ggtgcagccc ccgccagccc      480

cccaaccaaa gcctcccgca ccaagtcccc gggccccgcc aggcgcctct ccataaagat      540

gaagaagctg ccggaactgc ggcgccgcct gagcctgcga ggcccccggg ctggcaggga      600

gcgcgagagg gctgcccctg cgggctccgt catcagccgc taccacctgg acagcagcgt      660

ggggggcccc gggccggcag cagggcctgg gggcacccgg agcccgaggg ccggttacct      720

cagcgacggg gactcaccgg agcgcccagc tgggccccca tcacccacct ccttccggcc      780

ctacgaggtg ggtcccgcag cccgggcacc cccggccgca ctctggggcc gcctcagcct      840

gcacctgtac ggtctcgggg ggctgcggcc agcgccgggg gccaccccca gggacctctg      900

ctgcctactg caagtggatg gggaggccag ggcccgaaca gggccactgc gaggggggcc      960

ggacttcctg cggctggacc acaccttcca cctggagctg gaggccgcca ggctcctgcg     1020

cgccctggtg cttgcgtggg accctggcgt gagaaggcac cggccctgtg cccagggcac     1080

cgtgctgctg cccacggtct tccgagggtg ccaggcccaa cagctggccg tgcgcctgga     1140

gcctcagggg ctgctgtatg ccaagctgac cctgtcggag cagcaggaag cccctgccac     1200

agctgagccc cgcgtctttg ggctgcccct gccactgctg gtggagcggg agcggccccc     1260

cggccaggtg cccctcatca tccagaagtg cgttgggcag atcgagcgcc gagggctgcg     1320

ggtagtggga ctgtaccgtc tttgtggctc agcggcagtg aagaaagagc ttcgggatgc     1380

ctttgagcgg gacagtgcag cggtctgcct atctgaggac ctgtaccccg atatcaatgt     1440

catcactggc atcctcaagg attatcttcg agagttgccc accccactca tcacccagcc     1500

cctgtataag gtggtactgg aggccatggc ccgggacccc ccaaacagag ttccccccac     1560

cactgagggc acccgagggc tcctcagctg cctgccagat gtggaaaggg ccacgctgac     1620

gcttctcctg gaccacctgc gcctcgtctc ctccttccat gcctacaacc gcatgacccc     1680

acagaacttg gccgtgtgct tcgggcctgt gctgctgccg gcacgccagg cgcccacaag     1740

gcctcgtgcc cgcagctccg gcccaggcct tgccagtgca gtggacttca agcaccacat     1800

cgaggtgctg cactacctgc tgcagtcttg gccagatccc cgcctgcccc gacaatctcc     1860

agatgtcgcg ccttacttgc gacccaaacg acagccacct ctgcacctgc cgctggcaga     1920

ccccgaagtg gtgactcggc cccgcggtcg aggaggcccc gaaagccccc cgagcaaccg     1980

ctacgccggc gactggagcg tttgcgggcg ggacttcctg ccctgtgggc gggatttcct     2040

gtccgggcca gactacgacc acgtgacggg cagtgacagc gaggacgagg acgaggaggt     2100

cggcgagccg agggtcaccg gtgacttcga agacgacttc gatgcgccct tcaacccgca     2160

cctgaatctc aaagacttcg acgccctcat cctggatctg gagagagagc tctccaagca     2220

aatcaacgtg tgcctctgag ccagatgacg gggtgggacc ccggttagta aggaccgggc     2280

gcccagtggc taaggcggtg ccctggtgac caaggagagc cagacctgtt gctcaggccg     2340

agctcctggt tgccagcgag ttaccacggg accagtcgcg tgtatggctg agactcattc     2400

ccagtttcca gggcccggta tttggacact agttgccaag tctggggcct ggggatttta     2460

gggaccagcg gttgtgacca tctttcctga gcaccaaggg cttccccttt tgttgccaaa     2520

aaggtagttc tcgcgcttgc taggctggcc tctcttgcct ccccttggcc ggggcaacac     2580

cagttactgt gagcatcacc ctggtgtggt gagtcacctc tagtcggccc tcttgctgct     2640

gccaaccaaa tcagtattag ctttgagcac tgcactgttt ctccctccct tggacgacac     2700

aaagactagc atgaggcact gtttgtgggg ggcagcccct atcctgggtt ccagcatgga     2760

cacaggggta gcctggggct tatagagaaa cagctggttt cccctaccct tttccgggga     2820

agtccccacg attggcctct agtcagcaaa tggagataac agagtctggc ctttccaatc     2880

cccatctcct tgcccccccc ttgccccccc ccccgaaaaa aattgagcac ttaaacccct     2940

cccttttgga gggggccccc tgaagcgtca ggctgggggc agtctggtac ggaacatatt     3000

tattgcctcc atgcatgtgt gtgtgtgtct gtgaggactg gtgtgcgtgg acacgtctga     3060

agcaggcgtg tggggctctt tcagggacca cagaggaggg agcagtttgc agtgcccagc     3120

caccctgaaa tccccaataa tggtgcctca gtgggcccca gagttccagt gggagagtac     3180

ggttccctcc tgtctccctc ttcttttccg cacctccatc tttgtggata ataaataaat     3240

atgcacaggt tctg                                                       3254


<210> 1234
<211> 1461
<212> DNA
<213> Homo sapiens

<400> 1234
gcgtggcagg agaggcgggg ccaattttgc tgagctttct cgcgggcttg cagctgcggc       60

aagtgctggc ggcggctgct cgcgcaagtc agctggcgtg ggaactaccc tttgtagctg      120

agaacggctt gtttattgct acaaagactc tattgacatt ggtagcttca gcggcagcag      180

cttcttacgg tataaagctg ttgcttcctg aagaggctac aagcatcctt ccctaggact      240

gctgtaagct ttgagcctct agcaggagac atgcctcggg gacgaaagag tcggcgccgc      300

cgtaatgcga gagccgcaga agagaaccgc aacaatcgca aaatccaggc ctcagaggcc      360

tccgagaccc ctatggccgc ctctgtggta gcgagcaccc ccgaagacga cctgagcggc      420

cccgaggaag acccgagcac tccagaggag gcctctacca cccctgaaga agcctcgagc      480

actgcccaag cacaaaagcc ttcagtgccc cggagcaatt ttcagggcac caagaaaagt      540

ctcctgatgt ctatattagc gctcatcttc atcatgggca acagcgccaa ggaagctctg      600

gtctggaaag tgctggggaa gttaggaatg cagcctggac gtcagcacag catctttgga      660

gatccgaaga agatcgtcac agaagagttt gtgcgcagag ggtacctgat ttataaaccg      720

gtgccccgta gcagtccggt ggagtatgag ttcttctggg ggccccgagc acacgtggaa      780

tcgagcaaac tgaaagtcat gcattttgtg gcaagggttc gtaaccgatg ctctaaagac      840

tggccttgta attatgactg ggattcggac gatgatgcag aggttgaggc tatcctcaat      900

tcaggtgcta ggggttattc cgccccttaa gtagatctga ggcagaccct tgggggtgta      960

aaagagagtc acaggtaccc caaggagtag atgccagggt cctaagttga aaatgatgtc     1020

gattgggggc gggggacact gtatttgata tttgtgatca gtgatcattg ttcaactgcg     1080

aaatagagtg tttgcttttg ataatggaaa attgtattcg ttttaaaatt ccgtttgttg     1140

agaataacaa tatgtttaaa aatataattg aacaaatttt tttctttgtt tcctgtcatt     1200

gacatttagt ataacagttt tgctaacgtt ctaaaatgaa gtcgttccat cataatctat     1260

gatcttgtac agcacttata gaaataagct gttcttttga agttgaaata cccagtaaaa     1320

tgttgaagaa ggatggagga tttcttcata tctgacgttt ctgaaaccct ttgtgtctgc     1380

tgttgtgtga agattgacat ttaccatgat tttccttagt tactgcagaa catagagaaa     1440

aataaaagcc taacgaatag t                                               1461


<210> 1235
<211> 830
<212> DNA
<213> Homo sapiens

<400> 1235
tcctccactt cgtcccggcc cttgtcctgt ggcaggtgct ccgctcaaga tgaatctcaa       60

cttcacctct cctctacacc cggcgtcttc tcagaggccc acatccttct tcatcgagga      120

catcctgctg cacaagccca agccgctgag agaggtggcc ccagaccatt tcgccagctc      180

tctggcctct cgggtgcctc tgctagacta tggctacccc ctcatgccca cacccaccct      240

cttggctcct cacgcccatc accctctgca taagggagac caccatcatc cttatttcct      300

caccacctcg gggatgccag tcccagcgct gttcccgcac ccgcagcacg cggagctgcc      360

ggggaagcac tgccgccgcc gcaaagcccg cacggttttc tctgactcgc agctctcggg      420

cttggagaag aggttcgaga tccagcgcta cctgtccacg ccagaacgag tggagctggc      480

cacggccctc agcctgtccg agacgcaggt gaaaacgtgg ttccagaacc ggcggatgaa      540

gcataaaaag caactgcgga aaagccaaga cgaacccaaa gcaccagacg ggccagaaag      600

ccccgagggc agcccccgcg gttcagaggc cgccaccgcc gccgaggctc ggctgagcct      660

gcccgccggt cccttcgtgc tgaccgagcc agaggacgag gtggacattg gagacgaggg      720

ggagctgggc tcagggccgc acgtgctctg agccgccagg ctggggaggg tagtaggcag      780

gggaggagac tgcggggccg agcgcggttc cctcctggac cggaagactc                 830


<210> 1236
<211> 873
<212> DNA
<213> Homo sapiens

<400> 1236
atggagctgc cagctgttgg cgagcacgtc ttcgcggtgg agagcatcga gaagaagcgg       60

atccgcaagg gcagagtgga gtatctggtg aaatggagag gctggtcgcc caaatataac      120

acgtgggaac cggaggagaa catcctggac cccaggctgc tgatcgcctt ccagaacagg      180

gaacggcagg agcagctgat gggatatcgg aagagagggc cgaagcccaa accgctagtg      240

gtgcaggtgc ctacctttgc ccgtcgttcc aatgtcctga ccggcctcca ggactcctcc      300

actgacaacc gtgccaagct ggatttgggc gcgcagggga agggccaggg gcatcagtac      360

gagctcaaca gcaagaagca ccaccaccac gccgtcggcc tgaatctctc ccacgtgcgc      420

aagcgctgcc tctccgagac ccacggcgag cgcgagccct gcaagaagcg gctgactgcg      480

cgcagcatca gcacccccac ctgcctgggg ggcagcccag ccgctgagcg cccggccgac      540

ctgccaccag ccgccgccct cccgcagccc gaggtcatcc tgctagactc agacctggat      600

gaacccatag acttgcgctg cgtcaagacg cgcagcgagg ccggggagcc gcccagctcc      660

ctccaggtga agcccgagac accggcgtcg gcggcggtgg cggtggcggc ggcagcggca      720

cccaccacga cggcggagaa gcctccagcc gaggcccagg acgaacctgc agagtcgctg      780

agcgagttca agcccttctt tgggaatata attatcaccg acgtcaccgc gaactgcctc      840

accgttactt tcaaggagta cgtgacggtg tag                                   873


<210> 1237
<211> 826
<212> DNA
<213> Homo sapiens

<400> 1237
ggcgctgagt tttgtctccc gggccgtctg ggcgcgcgcg ggtgtcccag aatgaaatat       60

gactgaggac tctcagagaa actttcgttc agtatattat gagaaagtgg ggtttcgtgg      120

agttgaagaa aagaaatcat tagaaattct cctaaaagat gaccgtctgg atactgagaa      180

actttgtact tttagtcaga ggttccctct cccgtccatg taccgtgcat tggtatggaa      240

ggtgcttcta ggaatcttgc ctccacacca cgagtcccat gccaaggtga tgatgtatcg      300

taaggagcag tacttggatg tccttcatgc cctgaaagtc gttcgctttg ttagtgatgc      360

cacacctcag gctgaagtct atctccgcat gtatcagctg gagtctggga agttacctcg      420

aagtccctct tttccactgc caaaagcgtt tgaacaatac ttgaatctgg aagatggcag      480

actgctgact catctgagga tgtgttccgc ggcgcccaaa cttccttatg atctctggtt      540

caagaggtgc tttgcgggat gtttgcctga atccagttta cagagggttt gggataaagt      600

tgtgagtgga tcctgtaaga tcctagtttt tgtagctgtc gaaattttat taacctttaa      660

aataaaagtt atggcactga acagtgcaga gaagataaca aagtttctgg aaaatattcc      720

ccaggacagc tcagacgcga tcgtgagcaa ggccattgac ttgtggcaca aacactgtgg      780

gaccccggtc cattcaagct gaacgcaccc gctggttgtg gaccgt                     826


<210> 1238
<211> 877
<212> DNA
<213> Homo sapiens

<400> 1238
tagaaatcca cccagaacct ccaccctctg acaccatggt cagctcctgt tgtggctctg       60

tcagctctga gcagagctgt ggcctggaga actgctgccg ccccagctgc tgccagacca      120

cctgctgcag gaccacctgc tgccgcccca gctgctgcaa gccccagtgc tgccagtctg      180

tgtgctacca gcccacctgc tgccacccta gctgctgcat ctccagctgc tgccgcccct      240

attgctgtga atccagctgc tgccgcccct gctgctgcca gaccacctgc tgcaggacca      300

cctgctgcag gaccacctgc tgctgcccca gctgctgtgt gtccagctgc tgcagacccc      360

agtgctgcca gtctgtgtgc tgccagccca cttgctgccg tcccagctgc tgcatctcca      420

gctgctgcca cccctcttgc tgtgaatcca gctgctgccg cccctgctgc tgcgtgcgtc      480

cagtctgtgg ccgagtctcc tgccacacca cttgctatcg cccaacctgt gtcatctcca      540

cctgcccccg ccccttgtgc tgtgcctcct cttgctgcta atgtctcctt gtgatatttg      600

tcatactatg aatgtcttca ttagtcattt aaaatgcact gtagccagcc agtcactgga      660

aaaatgaaca cttccctgcc agtttgtctc atgtggcatt cagagtggac attcagctct      720

tctaggaaat gacagacaat cacattcatt aaaatatgtt atgccaggcc ccaatgcagt      780

tatttttaga tgagcagtgt cttcattcga aggggacact aactgtgatg atctcatata      840

atattgtttt catgtattaa taaacagcca cttccct                               877


<210> 1239
<211> 4572
<212> DNA
<213> Homo sapiens

<400> 1239
agcaacagag tttagactgt ctttgcttca tcatctgaag gtaaaatttt ccagatacgg       60

cagacggctt tcagagtaca ataaacaggg aatgagaact atttacatgg aagtttcttt      120

ctcatgatgc ggtggagaag cctcggccac ttggttctgc cagatgttcc tggggttact      180

gtaaatggga aggacaggca gagctaaaca aggtttatca tttaaaagtg cctgtgtgaa      240

gtcacttttg ctggaaaact gcagcttggg agctttcttt gtattcacat cccactcttc      300

tgtcaagtac actttaccct gaccttatga gtggatgaag atacctcagt tgtctgactt      360

tgccaattgc ttaatttcag aatttaaaaa ggggaaagaa aaacatcctg ctaaaatatg      420

aacatctgag tgtcttattt tccaacatcg tcaatagctg tgagcgtcag cattaaatat      480

tctcccaagg agtgccatga tattgaagtc actttattaa taacagctgt atctgcaaaa      540

cagtcaagag actcggacgt tgaaagccag agatgacact gagcatgctt ttattgcggc      600

ctaccatctt taagtgggac atattgattg atgagtgatt gcctgtccat acactctctc      660

atcatcctgt tccttggatt ggacttcact aagcaattta tcactcacct tcagacttac      720

atgtgggagt tttcacaaca gtagttttgg aatcattaga acttggattg atttcatcat      780

ttaacagaaa caaacagccc aaattacttt atcaccatgg ctttgaacgt tgccccagtc      840

agagatacaa aatggctgac attagaagtc tgcagacagt ttcaaagagg aacatgctca      900

cgctctgatg aagaatgcaa atttgctcat ccccccaaaa gttgtcaggt tgaaaatgga      960

agagtaattg cctgctttga ttccctaaag ggccgttgtt cgagagagaa ctgcaagtat     1020

cttcaccctc cgacacactt aaaaactcaa ctagaaatta atggaaggaa caatttgatt     1080

cagcaaaaaa ctgcagcagc aatgcttgcc cagcagatgc aatttatgtt tccaggaaca     1140

ccacttcatc cagtgcccac tttccctgta ggtcccgcga tagggacaaa tacggctatt     1200

agctttgctc cttacctagc acctgtaacc cctggagttg ggttggtccc aacggaaatt     1260

ctgcccacca cgcctgttat tgttcccgga agtccaccgg tcactgtccc gggctcaact     1320

gcaactcaga aacttctcag gactgacaaa ctggaggtat gcagggagtt ccagcgagga     1380

aactgtgccc ggggagagac cgactgccgc tttgcacacc ccgcagacag caccatgatc     1440

gacacaagtg acaacaccgt aaccgtttgt atggattaca taaaggggcg ttgcatgagg     1500

gagaaatgca aatattttca ccctcctgca cacttgcagg ccaaaatcaa agctgcgcag     1560

caccaagcca accaagctgc ggtggccgcc caggcagccg cggccgcggc cacagtcatg     1620

gcctttcccc ctggtgctct tcatccttta ccaaagagac aagcacttga aaaaagcaat     1680

ggtaccagcg cggtctttaa ccccagcgtc ttgcactacc agcaggctct caccagcgca     1740

cagttgcagc aacacgccgc gttcattcca acagataatt ctgaaataat cagcagaaac     1800

ggaatggaat gccaagaatc tgcattgaga ataactaaac attgttactg tacatactat     1860

cctgtttcct cctcaataga attgccacaa actgcatgct aaataaagat gtagttcttc     1920

tggacagacc acaactctaa gaagctagtg ctgctatctc atatatgagt attaaatatg     1980

gtatgcttag tatattccaa cctaagatag ttaactacct gagaccagct gtgatgttta     2040

aagacataaa ggataaagtt tacttttaaa gggtttctaa acatagtttc tgtcctagga     2100

atattgtctt atctccataa ctatagctga tgcagaaagt ccagccagtt tactcatttc     2160

gattcagaat atttcaaatt tagcaataaa caattagcat tagttaaaaa agaaacatat     2220

tccaagggca ggttcgattc tagctctaat tactgtcatg tcatttaccc actggatcaa     2280

agggtatgtt tcacttcttg acaatataaa tgctgcagca aagatgagag gtgaagtaaa     2340

accgatacct gtcctgcagg tctaaaattt gaatggaaat tcaagcacaa gtactgggga     2400

cacatcaaag tgtggtgttt ggtttgcctg gagatgccac gttgaatcat gtgattctag     2460

attaacatta aatagattga aaaagaaact ttgcacggta tgagcttcat accccaccaa     2520

acaaagtctt gaaggtatta ttttacaagt atatttttaa agttgtttta taagagagac     2580

tttgtagaag tgcctagatt ttgccagact tcatccagct tgacaagatt gagaggccca     2640

tgccaacagt ctaatctaag agattagtct ttcaaactca ccatccagtt gcctgttaca     2700

gaataactct tcttaactaa aaacctagtc aaacaaggaa gctgtaggtg aggagatctg     2760

tataatattc taatttaagt aagtttgagt ttagtcactg caaatttgac tgtgacttta     2820

atctaaatta ctatgtaaac aaaaagtaga tagtttcact ttttaaaaaa tccattactg     2880

ttttgcattt caaaagttgg attaaagggt tgtaactgac tacagcatgg aaaaaaatag     2940

ttcttttaat tctttcacct taaagcatat tttatgtctc aaaagtataa aaaactttaa     3000

tacaagtaca tacatattat atatacacat acatatatat actatatatg gatgaaacat     3060

attttaatgt tgtttacttt tttaaatact tggttgatct tcaaggtaat agcgatacaa     3120

ttaaattttg ttcagaaagt ttgttttaaa gtttatttta agcactatcg taccaaatat     3180

ttcatatttc acattttata tgttgcacat agcctataca gtacctacat agtttttaaa     3240

ttattgttta aaaaacaaaa cagctgttat aaatgaatat tatgtgtaat tgtttcaaac     3300

atccattttc tttgtgaaca tattagtgat tgaagtattt tgacttttga gattgaatgt     3360

aaaatatttt aaatttggga tcatcgcctg ttctgaaaac tagatgcacc aaccgtatca     3420

ttatttgttt gaggaaaaaa agaaatctgc attttaattc atgttggtca aagtcgaatt     3480

actatctatt tatcttatat cgtagatctg ataaccctat ctaaaagaaa gtcacacgct     3540

aaatgtattc ttacatagtg cttgtatcgt tgcatttgtt ttaatttgtg gaaaagtatt     3600

gtatctaact tgtattactt tggtagtttc atctttatgt attattgata tttgtaattt     3660

tctcaactat aacaatgtag ttacgctaca acttgcctaa aacattcaaa cttgttttct     3720

tttttctgtt tttttctttg ttaattcatt taaactcatt gaaaacatag tatacattac     3780

taaaaggtaa attatgggaa tcactgaaat atttttgtag attaattgtt gtaacattgt     3840

ctttcttttt tttcttttgt ttcatgattt tgatttttaa aattattagc acacaactat     3900

tttcagccct ttaataatgg agcatcaaaa acatcacctg taaccccaag caaatataga     3960

agactgtatt ttttactatg atatccattt tccagaattg tgattacaat atgcaaagag     4020

tcataaatat gccatttaca ataaggagga ggcaaggcaa atgcatagat gtacaaatat     4080

atgtacaaca gattttgctt tttatttatt tataatgtaa ttttatagaa taattctggg     4140

atttgagagg atctaaaact atttttctgt ataaatatta tttgccaaaa gtttgtttat     4200

attcagaagt ctgactatga tgaataaatc ttaaatgctt tgtttaatta aaaaacaaaa     4260

atcaccaata tccaagacat gaagatatca gttcaacaaa tactgtagtt aagagactaa     4320

ctctccactt gtatgggaac tacatttcac tcttggtttt caggatataa cagcacttca     4380

ccgaaatatt ctttcagcca taccactggt aacatttcta ctaaatcttt ctgtaacact     4440

taaagaattc cctcattcat taccttacag tgtaaacagg agtctaattt gtatcaatac     4500

tatgttttgg ttgtaatatt cagttcactc acccaatgta caaccaatga aataaaagaa     4560

gcatttaaaa gg                                                         4572


<210> 1240
<211> 1563
<212> DNA
<213> Homo sapiens

<400> 1240
cagaagaata gaaggaaggt gataggatgt gatgatagaa tttgtgatag ccaagcaaca       60

acttttccta attcggcatg ttaaaaaata agggtcactc atctaagaaa gataacttgg      120

cagtcaatgc agttgcttta caagatcaca ttttacatga tcttcaactt cgaaatcttt      180

cagttgcaga tcattctaag acacaagtac aaaagaaaga gaacaaatct ctaaaaagag      240

atacaaaggc aataatagat actggactta aaaaaactac acagtgcccc aaactagaag      300

actcagaaaa agaatatgtt cttgatccca aaccgccgcc gttgactttg gcacagaagt      360

tgggcctcat tgggcctcca ccacctccac tgtcatcaga tgaatgggag aaggtgaaac      420

agcgctctct cctgcaaggg gactccgtgc aaccatgccc catctgtaaa gaagaattcg      480

agcttcgtcc tcaggtgttt agcatacgag gaaagaacca gtatcaaacc cgagtgatac      540

acgatggggc ccgcctgttc agaatcaagt gtgtgaccag aatccaagcc tactggagag      600

gatgtgttgt tagaaagtgg tacagaaacc tgaggaaaac agtacctccc acagatgcca      660

agttaagaaa aaaattcttt gaaaaaaagt tcacagaaat cagccaccgc atcctgtgct      720

catacaacac caacattgaa gagctctttg cagaaatcga tcagtgcttg gccataaatc      780

gaagtgttct tcagcagttg gaagaaaaat gtggccatga gatcacagaa gaggaatggg      840

agaaaatcca agtgcaggct ctgcgccggg agacccacga gtgctccatc tgcctggccc      900

ctctctccgc tgctggcggt cagcgcgtgg gtgcaggcag gcgttccaga gagatggccc      960

tcctgtcctg ctcacatgtg ttccaccatg cgtgtctgct ggcactagag gagttctccg     1020

tgggagacag gcctcctttc catgcctgtc ctctctgccg ctcctgctac cagaagaaga     1080

ttcttgaatg ttgaattcat agtcaaggaa agttaggtaa ttctgaggaa aaaagtttac     1140

catcattttg gatgaactgc atgagttctg ggttaagtac tacaatgtaa tctgtttccc     1200

agggaaataa gctattggta gttgtaggaa atcttagtat attttaaaag ctgacatccc     1260

acctaatttt aatctttggt ctctaaaaag taaatttcaa atttatgagt ttaatcactt     1320

caaatatgaa tagcaaaaaa tgagagcttg cttacttcta aaaattgagg ttaagatata     1380

gctagtgtct gaacgacact ccttaaagta agttccaaat gtaaaacact ccttaagttc     1440

caaatgtttt ccgctaatag tctgtcctaa agcctttgcc attcctaata ctcgttttgt     1500

aataattgct gtatttctgt gtaataaaat ataaaaataa aatattcagt ggtattcaac     1560

atc                                                                   1563


<210> 1241
<211> 1217
<212> DNA
<213> Homo sapiens

<400> 1241
cagaagtttc ccccttgggc ggtggtggag gtggtaaccg tgatagtagc agctccggcg       60

gcagcaacag cgactacgag ggatggcggc ggctgcagca ggaactgcaa catcccagag      120

gtttttccag agcttctcgg atgccctaat cgacgaggac ccccaggcgg cgttagagga      180

gctgactaag gctttggaac agaaaccaga tgatgcacag tattattgtc aaagagctta      240

ttgtcacatt cttcttggga attactgtgt tgctgttgct gatgcaaaga agtctctaga      300

actcaatcca aataattcca ctgctatgct gagaaaagga atatgtgaat accatgaaaa      360

aaactatgct gctgccctag aaacttttac agaaggacaa aaattagata tagagacggg      420

gtttcatcgt gttggccagg ctggtctcca actcttgacc tcaagtgatc cacctgcctt      480

ggactcccaa agtgctggga ttacaggtgc agatgctaat ttcagtgtct ggattaaaag      540

gtgtcaagaa gctcagaatg gctcagaatc tgaggtgtgg actcatcagt caaaaatcaa      600

gtatgactgg tatcaaacag aatctcaagt agtcattaca cttatgatca agaatgttca      660

gaagaatgat gtaaatgtgg aattttcaga aaaagagttg tctgctttgg ttaaacttcc      720

ttctggagag gattacaatt tgaaactgga acttcttcat cctataatac cagaacagag      780

cacgtttaaa gtactttcaa caaagattga aattaaactg aaaaagccag aggctgtgag      840

atgggaaaag ctagaggggc aaggagatgt gcctacgcca aaacaattcg tagcagatgt      900

aaagaaccta tatccatcat catctcctta tacaagaaat tgggataaat tggttggtga      960

gatcaaagaa gaagaaaaga atgaaaagtt ggagggagat gcagctttaa acagattatt     1020

tcagcagatc tattcagatg gttctgatga agtgaaacgt gccatgaaca aatcctttat     1080

ggagtcgggt ggtacagttt tgagtaccaa ctggtctgat gtaggtaaaa ggaaagttga     1140

aatcaatcct cctgatgata tggaatggaa aaagtactaa ataaattaat ttgctctcat     1200

cgtattgtgt atattca                                                    1217


<210> 1242
<211> 1928
<212> DNA
<213> Homo sapiens

<400> 1242
cctggttcgt taaccggaag tagacgtacc tcacggaagc cggctttggc cctgcggctg       60

ctaccgtcgc cgcggagaaa ttgttggatc tggcagtcta ggaatgaatc tcctctcagc      120

ctttaagctc acctggtcag aatccttgga tgagcctgtg ggaccgttcc tcctagcccg      180

gtggtttgga accagtggct ttgggactgt aagaggatgg acaaagattc tcaggggctg      240

ctagattcat ccctgatggc atcaggcact gccagccgct cagaggatga ggagtcactg      300

gcagggcaga agcgagcctc ctcccaggcc ttgggcacca tccctaaacg gagaagctcc      360

tccaggttca tcaagaggaa gaagttcgat gatgagctgg tggagagcag cctggcaaaa      420

tcttctaccc gggcaaaggg ggccagtggg gtggaaccag ggcgctgttc ggggagtgaa      480

ccctcctcca gtgagaagaa gaaggtatcc aaagccccca gcactcctgt gccacccagc      540

ccagccccag cccctggact caccaagcgt gtgaagaaga gtaaacagcc acttcaggtg      600

accaaggatc tgggccgctg gaagcctgca gatgacctcc tgctcataaa tgctgtgttg      660

cagaccaacg acctgacctc cgtccacctg ggcgtgaaat tcagctgccg cttcaccctt      720

cgggaggtcc aggagcgttg gtacgccctg ctctacgatc ctgtcatctc caagttggcc      780

tgtcaggcca tgaggcagct gcacccagag gctattgcag ccatccagag caaggccctg      840

tttagcaagg ctgaggagca gctgctgagc aaagtgggat cgaccagcca gcccaccttg      900

gagaccttcc aggacctgct gcacagacac cctgatgcct tctacctggc ccgtaccgcg      960

aaggccctgc aggcccactg gcagctcatg aagcagtatt acctgctgga ggaccagaca     1020

gtgcagccgc tgcccaaagg ggaccaagtg ctgaacttct ctgatgcaga ggacctgatt     1080

gatgacagta agctcaagga catgcgagat gaggtcctgg aacatgagct gatggtggct     1140

gaccggcgcc agaagcgaga gattcggcag ctggaacagg aactgcataa gtggcaggtg     1200

ctagtggaca gcatcacagg catgagctct ccggacttcg acaaccagac actggcagtg     1260

ctgcggggcc gcatggtgcg gtacctgatg cgctcgcgtg agatcaccct gggcagagca     1320

accaaggata accagattga tgtggacctg tctctggagg gtccggcctg gaagatatcc     1380

cggaaacaag gtgtcatcaa gctgaagaac aacggtgatt tcttcattgc caatgagggt     1440

cgacggccca tctacatcga tggacggccg gtgctctgtg gctccaaatg gcgcctcagc     1500

aacaactctg tggtggagat cgccagcctg cgattcgtct tccttatcaa ccaggacctc     1560

attgccctca tcagggctga ggctgccaag atcacaccac agtgaggagt ggtggcagga     1620

ctcgtgggcc ctctccggcc tgtttcccct gccactccag cccccttgag ctgggaactc     1680

aggctcctgg aaaaacctgg gcagtgggag gctcagctgc gggccattga tttgagcctt     1740

tgagggagga tagggctggc ctttgtgaag ccagcagagg ctgagaacct caggcttccc     1800

tagatccaga gcccctcccc atcttcctct ctctaaaaac aaccctaccc cccattgcca     1860

ccttcactcc tgtgtctcca gctgattagc ctcagactct tcttttattg tttttctttt     1920

gtaaataa                                                              1928


<210> 1243
<211> 1689
<212> DNA
<213> Homo sapiens

<400> 1243
ggttgcacca tcccagaagc tgctgttagc tcgccggtcc tcggcacgcc gcccgttcgc       60

ccctgcgctg tccgcccttc ccctagcgtt acttccggtc cctcgctgag ggggttcgtg      120

cggctcccag gaggcgtgaa ccgcggacca tgagcgtggg cttcatcggg gccggccagc      180

tggcctatgc tctggcgcgg ggcttcacgg ccgcaggcat cctgtcggct cacaagataa      240

tagccagctc cccagaaatg aacctgccca cggtgtccgc gctcaggaag atgggtgtga      300

acctgacacg cagcaacaag gagacggtga agcacagcga cgtcctgttt ctggctgtga      360

agccacatat catccccttc atcctggatg agattggggc cgacgtgcaa gccagacaca      420

tcgtggtctc ctgtgcggct ggtgtcacca tcagctctgt ggagaagaag ctgatggcat      480

tccagccagc ccccaaagtg attcgctgca tgaccaacac acctgtggta gtgcaggaag      540

gcgctacagt gtacgccacg ggcacccatg ccctggtgga ggatgggcag ctcctggagc      600

agctcatgag cagcgtgggc ttctgcactg aggtggaaga ggacctcatc gatgccgtca      660

cggggctcag tggcagcggg cctgcctatg cattcatggc tctggacgca ttggctgatg      720

gtggggtgaa gatgggtttg ccacggcgcc tggcaatcca actcggggcc caggctttgc      780

tgggagctgc caagatgctg ctggactcgg agcagcatcc atgccagctt aaggacaatg      840

tctgctcccc tgggggagcc accatccacg ccctgcactt tctagagagt gggggcttcc      900

gctctctgct catcaatgca gttgaggcct cctgtatccg aacacgagag ctacagtcca      960

tggccgacca agaaaagatc tccccagctg cccttaagaa gaccctctta gacagagtga     1020

agctggaatc ccccacagtc tccacactga ccccctccag cccagggaag ctcctcacaa     1080

gaagcctggc cctgggaggc aagaaggact aaggcagcat ctgtcccctc tgtgattcag     1140

agcccttagt tgagagcccc tgccgcccct gccacccccc tgccccgctc ccaccattgc     1200

ccctcctcag ctgtgcaagg agaaagcatg cttaggaagt tttcaggtcc ttgtgataaa     1260

acctccttaa atctgttcag accaagcaat gcgagcttcc tctcctgtcc catgttggaa     1320

gttgctctga aggggtggta gatgctggaa gccagacaca accctgcgta cgctgctcag     1380

ttggtggaga ctggggctgg gactggagtc agcccagctg ggaggagggg ctggggagga     1440

tctgcagctg aagcccgagg cagggttggt gtgatgccaa ggcaaagtgg tgaggagaaa     1500

acaggaaacg ggctttctct gaattggtaa atgggaaaga agtgagcaac ttaagattgt     1560

cacaattaat cacaagtgta caggattaga ctgggtttat atttaactct tgcttcatag     1620

gtgtaccatt taaagagtgt tatttaatgc taagtttaac tgctttaata aagtttattt     1680

ttaaatatc                                                             1689


<210> 1244
<211> 8189
<212> DNA
<213> Homo sapiens

<400> 1244
gcggcggcgg ccaaactccg cggcgtcccc agggcgccag cttcgccctc gccgccgcgg       60

ccgcgctgct cttcggctcc gacatggaag atggaccttc taataatgcg agctgcttcc      120

gaaggctgac cgagtgcttc ctgagcccca gtttgacaga tgaaaaagtg aaggcatatc      180

tttctcttca cccccaggta ttagatgaat ttgtatctga aagtgttagt gcagagacag      240

tagagaaatg gctgaagagg aagaacaaca aatcagaaga tgaatcagct cctaaggaag      300

tcagcaggta ccaagatacg aatatgcagg gagttgtata tgaactaaac agctatatag      360

aacaacggtt ggacacagga ggagacaacc agctactcct ctatgaactg agcagcatca      420

ttaaaatagc cacaaaagcc gatggatttg cactgtattt ccttggagag tgcaataata      480

gcctgtgtat attcacgcca cctgggataa aggaaggaaa accccgcctc atccctgctg      540

ggcccatcac tcagggcacc accgtctctg cttatgtggc caagtccagg aaaacactgc      600

tagtagaaga catccttgga gatgaacgat ttccaagagg tactggactg gaatcaggga      660

ctcgtatcca gtctgttctt tgcttaccaa ttgtcactgc aattggtgac ttgattggta      720

ttctcgagct gtatcggcac tggggcaaag aagccttctg tcttagtcac caggaggttg      780

caacagcaaa tcttgcctgg gcttcagtag caatacatca ggtgcaggta tgcagaggcc      840

ttgccaaaca gacagaattg aatgacttcc tactcgacgt atcaaaaaca tattttgata      900

acatagttgc aatagattct ctacttgaac acataatgat atatgcaaaa aacctggtga      960

atgccgatcg ttgtgcgctt ttccaggtgg accataagaa caaggagtta tattcagacc     1020

tttttgatat tggagaggaa aaggaaggaa aacctgtctt caagaagacc aaagagataa     1080

gattttcaat tgagaaagga attgctggcc aagtagcaag aacaggggaa gtcctgaaca     1140

ttccagatgc ctatgcagac ccacgcttta acagagaagt agacttgtac acaggctaca     1200

ccacgcggaa catcctgtgc atgcccatcg tcagccgagg cagcgtgata ggtgtggtgc     1260

agatggtcaa caaaatcagt ggcagtgcct tctctaaaac agatgaaaac aacttcaaaa     1320

tgtttgccgt cttttgtgct ttagccttac actgtgctaa tatgtatcat agaattcgcc     1380

actcagagtg catttaccgg gtaacgatgg aaaagctgtc ctaccatagc atttgtactt     1440

cagaagagtg gcaaggtctc atgcaattca cccttcccgt gcgtctctgc aaagaaattg     1500

aattattcca ctttgacatt ggtccttttg aaaacatgtg gcctggaatt tttgtctaca     1560

tggttcatcg gtcctgtggg acatcctgct ttgagcttga aaagttgtgt cgttttatta     1620

tgtctgtgaa gaagaactat cggcgggttc cttatcacaa ctggaagcat gcggtcactg     1680

tagcacactg catgtatgcc atacttcaga acaatcacac gcttttcaca gaccttgagc     1740

gcaaaggact gctgattgcg tgtctgtgtc atgacctgga ccacaggggc ttcagtaaca     1800

gctacctgca gaagttcgac caccctctgg ccgctctcta ctccacttcc accatggagc     1860

agcaccactt ctcccagact gtgtccatcc tccagttgga agggcacaat atcttctcca     1920

ctctgagctc cagtgaatat gagcaggtgc ttgagatcat ccgcaaagcc atcattgcca     1980

cagaccttgc tttatacttt ggaaacagga agcagttgga agagatgtac cagaccggat     2040

cactaaacct taataatcaa tcacatagag accgtgtaat tggtttgatg atgactgcct     2100

gtgacctttg ttctgtgaca aaactgtggc ccgttacaaa attgacggca aatgatatat     2160

atgcagaatt ctgggctgag ggtgatgaaa tgaagaaatt gggaatacag cctattccta     2220

tgatggacag agacaagaag gatgaagtcc cccaaggcca gcttgggttc tacaatgccg     2280

tggccattcc ctgctataca acccttaccc agatcctccc tcccacggag cctcttctga     2340

aagcatgcag ggataatctc agtcagtggg agaaggtgat tcgaggggag gagactgcaa     2400

cctggatttc atccccatcc gtggctcaga aggcagctgc atctgaagat tgagcactgg     2460

tcaccctgac acgctgtccc acctacagat cctcatcttg cttctttgac attcttttcc     2520

tttttttggg gggggtgggg ggaacctgca cctggtaact ggggtgcaaa cctcttcaag     2580

aaggtaacat caaataaata agtcaagcag aggacttcct gccaatctct tctgtgaggc     2640

atcatagaca ctgagcaacc aggaccaccc ccacgttcag aaatcagctg gccaagtgac     2700

tccatttgac ttgcaaacca gccttttcta ataggctaat attgctgagg ccttaaagga     2760

aatggacaaa aattatccag aaggggtact tttccattgt atctttctaa taagggttta     2820

aaatggtact attatggtat tgtacttggg ctttaacatc aatgttgctt tgatgttgtt     2880

ggatataaat aggaattttt acacattact attgtgaatg gtgaatgttc atgtatgacc     2940

tacttgtaat taacttgagt tgtagtccac agcctcagga caaatgtcgt tgaggttaca     3000

gagtaagaaa tgatggcaaa acgtcaaact cttatttcag agcttcatga atttagttag     3060

actaaacata attctttaag ttcaacctaa agggctgaga tcaataaatt taacactaga     3120

cgaagtagac ttcctgtctt tttgagaaga gatgaggtat atgttacaat aaatctcaga     3180

acttcaagta gcagttcaaa agatgtcagt ttttaaaatt gtttttgttg ttgtcttggc     3240

agttttactg aaccctttgc ataaagaaca aaataaaagc tcggcattgt aattttttta     3300

atggacaagt cttatggata cgaagggtac atttttcata atgattcctt tatattttca     3360

ctttgtgtca ttgcagaatt ttagactctc attcacaatg aaaagtttat tttaaacatt     3420

gtttaattaa aataccatac agttctcttt taaacatcaa accataaaaa gtgtattttg     3480

taattttact ctgacctgcc gcagtcacct ctcacttatc tcttccacgt actgcacggt     3540

cgtatttcat gagctttctg tccatagcac agaaacagag cagaaagtag tacaatcatg     3600

ttggaccttc tttctgttct ctttactctt ctcacagatc agatcactcc atagaagcct     3660

gtgggtttcg atggtttctt ctatacacct ttttggttga ccagtattac tatacaatgt     3720

aagtgtttta aaaaatacga aagtaatact ctgcacccct tcctacaaag atgataaagc     3780

agtcacttct ggcgcatttt aataatttaa agatttttag tgcaatggca cggtaacctc     3840

caaacctgaa ttagacagag actcactcag gaagtgacag gcccatcata tcaaataact     3900

tattcacttt tcatgtggca ggaaactgga atatcgcttt taataaaatg gaaaaatatg     3960

cttctacata tttaccacca taggcgtttt gttcatatga gcctggtttg tgcaaaatta     4020

aatcagaggc ttctacaaca tggtttattt atgttgtagc aaagttggct ctacataaac     4080

attgttctta ttttaaaatt aacactatgt gttcagtttt cttgtgggct tctgaaagtt     4140

gccatcttcc ctccgtggag ctccatttgc tattttcatt atacactatg aggtaaaatg     4200

taataacaaa agagagagaa gtaccactgt ggctagatat atacacacac atatatatat     4260

ggatggatgt aatatatgta gaacacacac atagatgtat ataggataca cactcatgta     4320

tgtaaacgta tacatatgtg tatatatgat acatacacat acacacacac gagagacaga     4380

aggaaagaga ggaagagaga agcaaacatg taggaaaaaa tataaatcag ccccattctc     4440

ccattcttta agaacaatga tttttcttga tggaaaatgc atatcacttg acagttgaca     4500

agaaagtgtc atttttgtgt tagtgtatca tataattgaa tttgaacaag atacatattt     4560

ttctgcatac aaatttatga agctggagtc taccaaacac agctttagtc acaaaagtta     4620

gtttagttat ctcatttcgc ttggagatgg aatttcagga agggatatat tatttaagat     4680

tattgtttaa ttacaagaat tttaaaagaa tgtatgaatt ctgtttttta atatagaaaa     4740

taattatgga gttaggaatc tcatggctac atttacattt ttaggttatt acagaaaatt     4800

ctcttaattt attatagtca agtgtattat gtaatctcta tttagaacag tttcccaaag     4860

gaatgtgatt ggatttactg gttggttaat ttcttgtgaa atattgtcat aatagaagca     4920

cagcttgaac aaaagactga attctgatat aaactgtcaa tattgctttt accatgtgta     4980

agatttactt agtaatcaca gatttaccta aaataaaagg acccgggttg cagtgatatt     5040

tagttaatga tttgttttgg aaaacatgca gttaggagta tttttgtatt ttgtcagatg     5100

tttaggagac agactttcgg gtcatgtttc ttgtcttgtt cccagatctt ttcttaaaag     5160

aacagtgtga caccagaagc caagagatgg tttttactaa caacagcttt gatgagttcc     5220

tattaaggtc gtattgtgta ttgtgccaaa ttttccaccc agtataaatt tagtaacccg     5280

ctatgagcat atgtaggata ttcaatttgc agatactttt gttggttatg ttggtttata     5340

atagacaagt tttatggtca tatgcaatta ttccattatc tttttggaca cagtgaatat     5400

gttttttagc taaaaatgtc cttggaaaca taaatgcctg ccaataacat ggaatattga     5460

attcgggcaa tgtgaattga ttaattagaa aagggtcaaa agaaatacaa tggatgtgga     5520

aactaattct aaaaaatagc cctattaata gggcagagac tctggtccat ttcccagctg     5580

tacttctctc taagaggtgt atgaaaaacc catcttgcaa aagagaccaa aatattagac     5640

acaatcgttc ccattcctga ctcttcaatg gaaaaggaag gtacagatgt ttacagtggt     5700

gccccaggtg actcgttctc accacaacaa aagcaactaa ttggaaacta gatgtgttca     5760

ataatagatt tcctcttttt tggcatgctt tttagatttt ttttcatttt gtaaaatctc     5820

agttaatttt tctttattgg tatatttgtg tatgcgagac aaatcctgta ttgtacagga     5880

tataaataga tgcataaatc cttagatacc tgggtttttt aataggttta ggtttgggta     5940

ttgtgtttct ggtcttttaa ctcaaaatta aggtttgagc tttaatagga ctaaattatt     6000

cacctgcctt ggcctgtgcc tttattttaa atactgcaat tttacttctt cattcatgta     6060

tttattattt tgcttttctt gcttaagtat aattgaaaat atttgcagga acgcacaatt     6120

cattttatca agttgaatga ataggaccat tctctcctca tcagatttct gttctttatt     6180

tgacttcatt gacatatacc ctggtgacta taaccagtga actgttcaga gtcagtcttt     6240

tcggcaagaa cttcagagaa ctgtgacact ggttatgatg tgattttggg gggtttcagg     6300

tacctaagca tgatttttaa aatcacttct ctctttacat atttcgaaca tatgtttgct     6360

ttctacactt tgcagatttt atttaggatt taattcttta aagactatat tcatttagtc     6420

actatagtgg atctcttcta ctgcaagtat tcatctgatt tttaaattat gtaaaatgta     6480

aatcagccaa gtatgtcatc cgttatagtt tccccatgct ttcagcgcat ggccatgaga     6540

tttttacatg tgcataagta tttagccaat acacattttg ctgacttctt taaccattta     6600

tattgtttaa attagtaata tccaatgcag tgcacacttt tttgtctttt ttccaacgga     6660

atattttggt tgtctgtagc gttggaagca ttttatatga taaaaatagc aagaaaaaat     6720

taaaaagtgt caacggtgtg ctggttctaa attaagaaga tagaacaaag agaaagacat     6780

taatgttacc taagaaacac atttaacatc cgaagaagca atgctgtcct cacttgatgt     6840

ttctcttctc aacccagcaa tggagagcag ggcttgcaaa gccgtacaga gcctacgtgc     6900

tctttcctgc aagtgggaga aaactaatca atggcacaca gggccaggtg tggccctgtg     6960

aggcaaagga taatgtcacc tcaggaccaa ggtggaaact tacagctgaa tccagggctt     7020

actaagtagg gaagtcagtt tacatatttc agttttcctc tgatgttttt gaggtactgt     7080

gtatttgcag aagtttaagc agaagggttt tgtttctatt gtaagttagg ttctaaaagt     7140

gtataatctg atactctagc ccaactgaaa tattatatct tgggcgttac agcctttgtc     7200

tttttcttta gtcaccttaa tacccagtcc tatgctgtat ctctgatagc ctatataaat     7260

gacatatagg aatattattt tccatatgat ctgttgtatg gtgtatatgc tatgtgttca     7320

tttcgtgtgc aagttcagag tgtaatagat ttacccagag aaggtgtttc tatacaatgc     7380

ccctacctat ttgaaattac atgcttgccc aacacactgt gaaatagtta ccaaaatttg     7440

tacaaatgca gcatcttcat tctttctgag aagacaagat ggttttcttt acatgaacaa     7500

atgaacaaaa gagatcctag atccataacg tagctaaggc atctaagagt ttgctgttga     7560

taatcttgct gaccaaaaac tactggagag taacacaggt tatatgccat cacaaataca     7620

atgctcatga agaactgatt tgtagagtca atgaacctgt gtccagaatt ttaataggct     7680

ctctattgga aggagaaaga atttcaagtt aacagtatct aactttatca tagttgatgt     7740

tagtaaattt taaaaaatga ttttatatgt atgacaaaaa tctttgtaaa atgcgcaagt     7800

gcaataattt aaagaggtct taactttgca tttataaatt ataaatattg tacatgtgtg     7860

taattttttc atgtattcat ttgcagtctt tgtatttaaa aaacatttac tgttatgttt     7920

gtataataga acagtaatca tttattataa tctaggcaag ttgtaaataa attcataatt     7980

caaacagcca gtatatatgc atatatgagt gttatattgc aaaatctttg ttttacttac     8040

atggttaaag cagcaagaat tcttttgttg atatgtaatt atacacataa aatatatata     8100

tgtatgatac atgaaatata tttagaaatg ttcataattt taatggatat cctttggtgt     8160

gaataattga atacagagtt tttaaaata                                       8189


<210> 1245
<211> 2190
<212> DNA
<213> Homo sapiens

<400> 1245
gagggcgggg cgagggcggg gcggtgggcg gggacggggc ccgcacggcg gctacggcct       60

aggtgagcgg ctcggactcg gcggccgcac ctgcccaacc caacccgcac ggtccggaag      120

tcgccgaggg gccgggagcg ggaggggacg tcgtcctaga gggccggagc gggcgggcgg      180

ccgaggaccc ggctcccgcg caggacggag ccgtggctca ggtcggcccc tccccaacac      240

caccccgggc ctccgcccct tcctgggcct ctcggtggag cagggacccg aaccggtgcc      300

catccagtcc ggtgccatct gaagccccct tcccagaaaa tgagccacag agcaagctga      360

ccccagcgac acagcccccc agccctactg tatttccgtt cctatcaaaa aatggatgac      420

tcggagacag gtttcaatct gaaagtcgtc ctggtcagtt tcaagcagtg tctcgatgag      480

aaggaagagg tcttgctgga cccctacatt gccagctgga agggcctggt caggtttctg      540

aacagcctgg gcaccatctt ctcattcatc tccaaggacg tggtctccaa gctgcggatc      600

atggagcgcc tcaggggcgg cccgcagagc gagcactacc gcagcctgca ggccatggtg      660

gcccacgagc tgagcaaccg gctggtggac ctggagcgcc gctcccacca cccggagtct      720

ggctgccgga cggtgctgcg cctgcaccgc gccctgcact ggctgcagct gttcctggag      780

ggcctgcgta ccagccccga ggacgcacgc acctccgcgc tctgcgccga ctcctacaac      840

gcctcgctgg ccgcctacca cccctgggtc gtgcgccgcg ccgtcaccgt ggccttctgc      900

acgctgccca cacgcgaggt cttcctggag gccatgaacg tggggccccc ggagcaggcc      960

gtgcagatgc taggcgaggc cctccccttc atccagcgtg tctacaacgt ctcccagaag     1020

ctctacgccg agcactccct gctggacctg ccctaggggc gggaagccag ggccgcaccg     1080

gctttcctgc tgcagatctg ggctgcggtg gccagggccg tgagtcccgt ggcagagcct     1140

tctgggcgct gcgggaacag gagatcctct gtcgcccctg tgagctgagc tggttaggaa     1200

ccacagactg tgacagagaa ggtggcgacc agcccagaag aggcccaccc tctcggtccg     1260

gaacaagacg cctcggccac ggctccccct cggcctatta cacgcgtgcg cagccaggcc     1320

tcgccagggt gcggtgcaga gcagagcagg caggggtggg ggccgggcct gcaagagccc     1380

gaaaggtcgc caccccctag cctgtggggt gcatctgcga accagggtga agtcacaggt     1440

cccggggtgt ggaggctcca tcctttctcc tttctgccag ccgatgtgtc ctcatctcag     1500

gcccgtgcct gggaccccgt gtctgcccag gtgggcagcc ttgagcccag gggactcagt     1560

gccctccatg ccctggctgg cagaaaccct caacagcagt ctgggcactg tggggctctc     1620

cccgcctctc ctgccttgtt tgcccctcag cgtgccaggc agactggggg caggacagcc     1680

ggaagctgag accaaggctc ctcacagaag ggcccaggaa gtccccgccc ttgggacagc     1740

ctcctccgta gcccctgcac ggcaccagtt ccccgaggga cgcagcaggc cgcctcccgc     1800

agcggccgtg ggtctgcaca gcccagccca gcccaaggcc cccaggagct gggactctgc     1860

tacacccagt gaaatgctgt gtcccttctc ccccgtgccc cttgatgccc cctccccaca     1920

gtgctcagga gacccgtggg gcacggaaca ggagggtctg gaccctgtgg cccagccaaa     1980

ggctaccaga cagccacaac cagcccagcc accatccagt gcctggggcc tggccactgg     2040

ctcttcacag tggaccccag cacctcgggg tggcagaggg acggccccca cggcccagca     2100

gacatgcgag cttccagagt gcaatctatg tgatgtcttc caacgttaat aaatcacaca     2160

gcctcccagg agggagacgc tggggtgcac                                      2190


<210> 1246
<211> 9288
<212> DNA
<213> Homo sapiens

<400> 1246
agtgctcgcc cgcccgaccc cggcggctcg cgcccgggag cgccgcaggg tcgctagagt       60

cggccgcgtc ctttgtgtgg cgctcaggct gcgccgcggg gcggcgggac ggaatgtggg      120

cgctgcgggg gcttttctct cctacccgaa ctgtgggaac aatggactga aaggggaaga      180

tggattgagg ggccgagcgg ggaagcgagc tgcaccgggg aatcatgact tctgcagccg      240

agataaagaa gccaccagtg gcccccaagc ccaagtttgt tgtggcaaat aataagccag      300

ccccacctcc tattgcacct aaacccgaca ttgtgatttc tagtgttcca cagtcgacaa      360

agaaaatgaa accagcaata gccccaaaac caaaagtcct gaagacctca cctgttcgag      420

agattgggca gtcgccatca aggaaaatca tgttgaacct ggaagggcat aaacaggaat      480

tagctgaaag cactgacaac tttaattgta aatatgaagg caatcagagc aatgattata      540

tttcaccaat gtgttcctgc agttctgagt gtatccataa gctgggccat agagagaatt      600

tgtgtgtaaa gcagcttgtt ttagagcccc tggaaatgaa tgaaaattta gaaaacagta      660

aaattgatga gactttgact ataaaaacta ggagtaaatg tgatttgtat ggtgaaaaag      720

ccaagaacca gggtggggtt gttttaaagg caagcgtttt agaagaggag ctcaaagatg      780

ccttaataca ccaaatgcca ccttttattt ctgcacagaa gcacaggccc acagacagcc      840

cagaaatgaa tggtggctgt aattcaaatg gacaattcag aattgaattt gcggatttgt      900

caccttcccc atccagcttt gaaaaagttc ctgatcatca cagttgccac ttacagcttc      960

ctagtgatga atgtgaacat tttgaaactt gccaggatga cagtgaaaaa agcaataatt     1020

gctttcagtc atctgaacta gaggctctgg aaaatgggaa aaggagtact ttaatatctt     1080

cagatggagt tagtaagaaa tcagaagtca aagaccttgg tcccttagaa attcatttag     1140

taccatatac cccaaaattt ccaactccca agcccagaaa gacacgaact gctcgtctgt     1200

tacgccaaaa gtgtgtagat actcctagtg aaagcactga agaaccgggg aattcagaca     1260

gtagctcttc ctgtcttact gaaaatagtt tgaaaatcaa taaaatcagt gttctgcatc     1320

agaatgtttt gtgtaagcag gaacaggtgg ataaaatgaa gctaggaaat aaaagtgaat     1380

tgaatatgga atccaacagt gatgcacagg acttagtcaa ttcacagaaa gccatgtgta     1440

atgaaacaac ttcctttgaa aaaatggcac cttcttttga taaagactct aatttgagtt     1500

ctgacagcac aactgtagat ggttctagta tgtcgcttgc tgtggacgaa gggaccggtt     1560

ttataagatg tactgtatct atgagcctgc ctaagcagct caaattaact tgcaatgaac     1620

atttgcaatc tgggagaaac ctgggagttt ctgcccctca aatgcaaaag gaatctgtta     1680

taaaagagga aaattctcta cgaattgtcc ccaaaaaacc tcaaagacat agcttgcctg     1740

ctacaggagt gcttaaaaag gctgcctccg aggagctttt ggaaaaaagt tcttatcctt     1800

caagtgaaga aaaaagttca gagaagagtc tagaaagaaa tcaccttcag catttgtgtg     1860

cccaaaaccg tggtgtgtca tcctcctttg atatgcctaa acgggcttca gaaaagccag     1920

tgtggaagtt acctcatcct attttaccct tttcagggaa cccagaattc ttaaagtctg     1980

tcaccgtatc gtcaaacagt gagccttcaa cagccctaac caagcccaga gcaaaatcgt     2040

tatctgctat ggatgtggaa aagtgcacta agccttgcaa agactctaca aagaaaaact     2100

cttttaaaaa gttgctcagc atgaaactgt ccatctgttt catgaagagt gactttcaaa     2160

aattttggtc caagagtagc caactcggag acaccaccac aggccacctc tccagtgggg     2220

agcagaaggg gattgaaagt gattggcaag gcttgttggt aggagaggag aagagaagta     2280

aacccatcaa ggcatattcc acagaaaact atagcctgga atctcaaaag aagaggaaga     2340

agtctcgggg ccagaccagt gcagctaatg gtctgagagc tgagtctttg gatgaccaaa     2400

tgctctcccg ggagtcatca tctcaggcac cttacaagtc tgttacaagc ctctgtgcac     2460

cggagtatga aaatatacgc cattatgagg aaataccaga gtacgagaac ttgccattta     2520

ttatggctat acggaaaact caagagttgg aatggcagaa ttccagcagc atggaggacg     2580

ctgatgcaaa tgtgtatgag gtagaagagc cgtatgaagc tccagatggc cagctgcagc     2640

ttggacccag acatcagcat tccagttcag gagcatccca ggaggaacag aatgatcttg     2700

gtcttggtga ccttccctct gatgaggagg aaatcatcaa cagttctgat gaagatgatg     2760

tcagctctga gtcaagtaaa ggagagcctg acccactgga agataaacag gatgaagata     2820

atggaatgaa aagtaaagtt catcatattg ccaaggagat catgagctca gagaaagtgt     2880

ttgtggatgt gttaaaactt ttgcatattg atttccggga tgcagtagct catgcttcca     2940

ggcaacttgg gaaaccagtg attgaggacc ggattctaaa tcagatccta tactacttgc     3000

ctcagctgta tgagctcaac cgggatctct tgaaggaact ggaggaaaga atgttgcact     3060

ggactgaaca acaaagaatt gctgatatct ttgtaaagaa gggaccatat ctaaaaatgt     3120

attccacata catcaaagaa tttgataaga atatagcctt gctggatgaa cagtgcaaga     3180

aaaatccagg ttttgctgct gttgttagag aatttgagat gagccctcgc tgtgctaatc     3240

tggccctcaa gcactacctg ctcaagccgg ttcagaggat cccccagtac aggctgttgc     3300

tgacagatta tttgaagaat ctcatagaag atgctggaga ttacagagac actcaagatg     3360

cccttgctgt tgttatagag gtagccaacc acgccaatga caccatgaag caaggagaca     3420

actttcagaa acttatgcaa attcagtaca gcttaaatgg acaccatgaa attgtgcagc     3480

ctggtcgggt ttttctcaaa gaaggaattc tgatgaagct gtctcggaaa gtgatgcaac     3540

ctcgaatgtt tttcctgttt aatgatgccc tgctgtatac aacaccagtg cagtctggga     3600

tgtataaact gaacaacatg ctctcactgg ctggaatgaa ggtcagaaaa cctacccaag     3660

aagcctatca gaatgaatta aagattgaaa gtgtagaacg ttccttcatt ctctcagcca     3720

gttctgccac agaaagggat gaatggctag aagcgatttc cagggcaata gaagagtatg     3780

ccaagaaaag aatcaccttc tgtcctagta ggagtcttga tgaggcagac tcagaaaata     3840

aagaagaagt tagtcctctt ggatcgaagg ctcccatctg gattcctgat accagagcca     3900

caatgtgtat gatctgcaca agcgaattca ctctcacctg gagacgacac cactgccggg     3960

cctgtggaaa gattgtatgc caagcttgtt cgtctaataa gtatggctta gattacctga     4020

aaaatcaacc agcaagagta tgtgaacatt gtttccaaga actgcagaaa ttagatcacc     4080

agcactcccc taggattgga tctcctggaa atcacaaatc tccttcaagt gccttatcat     4140

cagtcttaca tagcattcca tcagggagga aacagaaaaa aatcccagct gctctcaaag     4200

aagtatcagc aaacacagag gattcttcta tgagtggcta cttgtacaga tcaaagggca     4260

ataaaaaacc ctggaaacac ttttggtttg tcataaaaaa taaagtacta tatacatatg     4320

ctgcaagtga ggacgtggcc gctttggaga gtcagccttt attaggattc actgttattc     4380

aagttaaaga tgagaattcc gagtctaaag tatttcagtt actgcacaaa aacatgttat     4440

tttatgtatt caaagcagag gatgctcatt cggctcagaa gtggatagaa gcatttcagg     4500

aaggcacaat attgtagcag tattggtttc atctcttctg tgattccaaa gaggtggaat     4560

ttcatcagaa tggagtaaat gcaattcaaa aattgtataa aaatgaacac tgccaagata     4620

aagccaacca gacccttcat caaagaaatt gttttgttag gtataagcaa tttttaaaag     4680

gtgtttgttt tttcatttat gttatttatt aaaattttga tgtttactta atggtcagaa     4740

ttatttctga gacacactga attctaaagt accatttctt tagagaccag aaaaactatc     4800

ttaatactgt atactgtatt aactattcgt gacatagttc acactgtttt cttaccttac     4860

attgtaacaa tcttactggt ggaaagtctt tgtaaggaaa aaacacatag caaggagcaa     4920

atttccacaa agtgcttggt ttaggaattg tgattattat aaaactgctg atgaaaaaaa     4980

tgcatgtctt tgaatcaata aacttgggtg aatatttgta tcttttagtg gaaaaacatg     5040

gccagcttct acctcagtaa ctgtgaactg aaatttcagt aaattatcta aagtatttct     5100

gttgttaggt acctctttgg caggagttaa tattacatca tcaaagaatt atagcaaaga     5160

gatagaatct gaatttttta aaactgtgag taggaatgaa gatgttttta tttgcagaat     5220

accacaaata accaactctt ccggctttta agtccaatct tttaaaaaat ctaccacttc     5280

gaaacaaaca taaatgtatc attttttaaa atagcaaaat atagcaagca ttatgtcaca     5340

taatattccc tgctattata agagttctga gcccaagtca atgatgatat ttgtatctat     5400

aagtaatgtt acatttccaa aaatattgtg cattacaaat ggaactggaa ttactatatc     5460

agaaaagcat aattataagc cagtaataac tgaaattcta tagtattcat tttcaaaagg     5520

tctttttctg ccagtttgtg atatcctccc tcctaattaa aaaaaaaaac aacaaatcct     5580

ttctctataa gcagctatca gcacacctcc ttaggaaaga tttagattca taattctggt     5640

gcacttactg tttaacatat gaactacctt gcacatacaa ttgttgatta gcagaagaaa     5700

atgaaataac actgtgataa aagccatccc tgatgttcac aatacacaat ttattaacta     5760

agtttaaact ataaattatc ttaactgcca tgagcggtgg ctcacaccta caatctcagc     5820

attttgggag gccgaggccg ttggaccacc tgaggtcagg agatcgagac cagcctggcc     5880

aatatggtga aaccccatct ctattaaaaa tacaagaatt agccggtcgt ggtggtacat     5940

ggctgtagtc ctagctattc agcaggctga ggcaggagca tcgcttgaac ccaggaggca     6000

gaggttgcag tgagccgaga tggtgccact gcactccagc ctgggatgac agagcgagac     6060

tccatctcaa aaaaaaaaaa aaaaaaaaaa ttgaacagca aggttatcca tataatattt     6120

ctttaaaggg tacaagaatt ttcctttctg cctctaaata aaggatttcc taattcagtg     6180

tgatccttaa cagcaaccat gaggattact gagtgccttt ctggggcctt ttgaatgctg     6240

tttggtacag caccagagtc cctactagat ctagagttgg ctgctatagt tttttgtggc     6300

gattttttgc catggagtca tttgaacctc atacacaatc ctaacatgcc atcccctttc     6360

tgtcatagca ggtacactaa aatttctttg tagctcaatt ttatataatc aagatcacat     6420

aaataaggct tccatgttag aatcgttgca gtttttagtg tattcctttt tggaggctaa     6480

agttgtacct tataaactgt ttctgcgtct ggcatttagc aagacaagtt atttgggttt     6540

tctttccctc ctcttgagct ctcagccttc tgactacaag gtttggctta agccttataa     6600

tctaaaaaat atcagccagg ctattctatc ttctaagacc tggctgaatc atgagccagt     6660

tctaaatcta aagagagtga gagagggaag aaatctggca caaacttaca gtctctttaa     6720

ttacatgtaa aatgcatgtg actgtattac ctattggctt agccccatgg agggtttaga     6780

aaaatgtgta gtctttgtgg aagctatcca attatccttc tcccaaaaag atgttttaaa     6840

tgtggaatag tattacattc ccctgcccct ttatgagtcc ttcataactt actaaagctg     6900

accaattgtt atttatgtaa cctggctcat tcattgtcaa ctaagaacct aattatatgc     6960

aatttattgt aaaaaaagct ataaaaatat attttgctag tattttagag gaaaaatgat     7020

attgggcaca gtctataaat ggggagaaaa gttaagtagt atctagattc caaggatact     7080

atatttatta tacagatatg tgtgcctgtg cttccatcaa accctttttc aggtatctcc     7140

ttttaattca taaggaggaa agagtagggc atttataaag ctaagctaaa aatgatgcta     7200

agcataacgt agatgagacg ccaggctgaa ccaggggaag gctggcattg ttagtgtccc     7260

caactagcag tccaccttta tctgtggcag ctataaatgt acaggaccca tcagagtcct     7320

aagaaaatga gagtaattat ctctggcatc atccacattt ccgactcttt ccaatctctt     7380

ttcccttttt ctgtaatgta cccagcatcc ccctattgta ttttggttgc ccaagattct     7440

tgattctttg agtgtgtagt agcatttctt aaaatgagat catcagacca acccttgatt     7500

cacatgaaag ctgtaatgac acaacaaaga gaaggcgaca gttttaaagt ataattgtca     7560

gccaaatgtg tattttatat ttggttcata gaatatatct agatgtgggg aaagtctcct     7620

atttggtaat ttagttaaaa tgtaaatgtt atatcacagc atatgttggt atgttttgga     7680

gtgtgcttcc attgtgctca gcttttgaaa agtttgaaat ccactttagt caaatgtagt     7740

caatgggatt tccagagata catattgttt ttcttagtgt accacacact ccttgaaggc     7800

agatactgta cttaatatat cactgtcttc cataatactg ccctaggtct ttttagtttt     7860

taagagaccg ggtctcgcta tgtttcccat gctgaactca aatgcctggg cttaagcaat     7920

cctcccacct cagcctctgg agtagctggg actacagggg catgcaccac caggcctggc     7980

ttcctaggag ggtctttaaa gagaaaatat ttgttcaatt gaaaacagga ttcttgtcat     8040

ctacaactcc aacacagcct gaaaatatcc acattataac ctggacctta gacctacttt     8100

ctccactatc ctgcaaagct acatctgtaa ctacctattg gctatctata tgagtcctca     8160

agcatctcag actttacatg aataaaactc aacttccttc ccattcaaat ctgtttattt     8220

tcttctgtaa gagaaagata ccatttgaga ctccagaatc tgcctctaac tctcaacaag     8280

actctgcaat tactcaagta tcctttccat cctcattgcc ctgctgttat tacataggcc     8340

ctggttcaag tccttgttac ttgttcccat tattgcaata acttctaatt ccaatgccgt     8400

tgtgtgatcc cattttaaac acggccagag cagtcttcca acaacatagc tctaatctag     8460

tttcatcccc acttttacat gcctcagtgg ctttcccagt gacttggcat ggaacacgtc     8520

ctcagttgcc atacattcca gctaactctt acccaacctt tctttgttca cacagtttcc     8580

ttttccttcc tcattgaccc atccgcatct ctgtttatcc aagacttctc tgtgatagct     8640

gacccttagt ctttctctcc cctattcctc cagactagat cctgtctcct tcctgcagcc     8700

ccgacacagc cttcagttca tatcttttgc atgatgctta gcaccttcta tccctaagga     8760

caacttactc atttgagatt tctggcaggg taccttgcat gcagtggaca ctcagtattt     8820

gctgaattaa attccttcct atggatccct tctgattttt tttaagtgcc tctaatacac     8880

atatcattct agggctcatg ccacttttaa tgtcattttc taaaggaaaa tcttatctat     8940

gatattttcc cttataagag atagttgttt tgagtagggt tttttaaaag ataaaggtag     9000

taggaaattt tttaaagcct aaatatcaaa ttcctttccc tttggagttg ggggaaggaa     9060

tgaaggggga gcaacttgct ctttcatatg agttggtcat agcatgtaag aaccaatctt     9120

gaaatatcgt ttttttttta atggcttata atgtatttct agaaatactt tgtacttaaa     9180

atgataacag tttgtatctt tttgtccata tatactttat aaataaaaaa attagcattg     9240

taaataatgt taatatgtat ttatacaaaa taaatttact ataatata                  9288


<210> 1247
<211> 2311
<212> DNA
<213> Homo sapiens

<400> 1247
ggcgagttgc taaggaaatg actgcccgca gcgcctggcc ccgccgcgca ggccgggcgg       60

ggtctggagc ggcgccgttt ccgcttccgc tccctcacag ctcccgtccc gttaccgcct      120

cctggccggc ctcgcgcctt tcaccggcac cttgcgtcgg tcgcgccgcg gggcctgctc      180

ctgccgcgcg cacccccggg gcttcggctc cggcacgggt cgcgcccagc tttcctgcac      240

ctgaggccgc cggccagccg ccgccatggg tgcctacctc tcccagccca acacggtgaa      300

gtgctccggg gacggggtcg gcgccccgcg cctgccgctg ccctacggct tctccgccat      360

gcaaggctgg cgcgtctcca tggaggatgc tcacaactgt attcctgagc tggacagtga      420

gacagccatg ttttctgtct acgatggaca tggaggggag gaagttgcct tgtactgtgc      480

caaatatctt cctgatatca tcaaagatca gaaggcctac aaggaaggca agctacagaa      540

ggctttagaa gatgccttct tggctattga cgccaaattg accactgaag aagtcattaa      600

agagctggca cagattgcag ggcgacccac tgaggatgaa gatgaaaaag aaaaagtagc      660

tgatgaagat gatgtggaca atgaggaggc tgcactgctg catgaagagg ctaccatgac      720

tattgaagag ctgctgacac gctacgggca gaactgtcac aagggccctc cccacagcaa      780

atctggaggt gggacaggcg aggaaccagg gtcccagggc ctcaatgggg aggcaggacc      840

tgaggactca actagggaaa ctccttcaca agaaaatggc cccacagcca aggcctacac      900

aggcttttcc tccaactcgg aacgtgggac tgaggcaggc caagttggtg agcctggcat      960

tcccactggt gaggctgggc cttcctgctc ttcagcctct gacaagctgc ctcgagttgc     1020

taagtccaag ttctttgagg acagtgagga tgagtcagat gaggcggagg aagaagagga     1080

agacagtgag gaatgcagcg aggaagagga tggctacagc agtgaggagg cagagaatga     1140

ggaagatgag gatgacaccg aggaggctga agaggacgat gaagaagaag aagaagagat     1200

gatggtgcca gggatggaag gcaaagagga gcctggctct gacagtggta caacagcggt     1260

ggtggccctg atacgaggga agcagttgat tgtagccaac gcaggagact ctcgctgtgt     1320

ggtatctgag gctggcaaag ctttagacat gtcctatgat cacaaaccag aggatgaagt     1380

agaactagca cgcatcaaga atgctggtgg caaggtcacc atggatgggc gagtcaacgg     1440

gggcctcaac ctctccagag ccattgggga ccacttctat aagagaaaca agaacctgcc     1500

acctgaggaa cagatgattt cagcccttcc tgacatcaag gtgctgactc tcactgacga     1560

ccatgaattc atggtcattg cctgtgatgg catctggaat gtgatgagca gccaggaagt     1620

tgtagatttc attcaatcaa agatcagcca gcgtgatgaa aatggggagc ttcggttatt     1680

gtcatccatt gtggaagagc tgctggatca gtgcctggca ccagacactt ctggggatgg     1740

tacagggtgt gacaacatga cctgcatcat catttgcttc aagccccgaa acacagcaga     1800

gctccagcca gagagtggca agcgaaaact agaggaggtg ctctctactg agggggctga     1860

agaaaatggc aacagcgaca agaagaagaa ggccaagcga gactagcagt catccagacc     1920

cctgcccacc tagactgttt tctgagccct ccggacctga gactgagttt tgtctttttc     1980

ctttagcctt agcagtgggt atgaggtgtg cagggggagc tgggtggctt cactccgccc     2040

attccaaaga gggctctccc tccacactgc agccgggagc ctctgctgtc cttcccagcc     2100

gcctctgctc ctcgggctca tcaccggttc tgtgcctgtg ctctgttgtg ttggagggaa     2160

ggactggcgg ttctggtttt tactctgtga actttattta aggacattct tttttattgg     2220

cggctccatg gccctcggcc gcttgcaccc gctctctgtt gtacactttc aatcaacact     2280

ttttcagact aaaggccaaa acctaatcgt a                                    2311


<210> 1248
<211> 3666
<212> DNA
<213> Homo sapiens

<400> 1248
gtgctcggcg ctcccggggt gcctgctcgg cgctccgccg gccgccctgc gtacgctcgc       60

aaggcgctcg cagactccgg agtcgccaac atgtcgaccg ccatgaattt cgggaccaag      120

agcttccagc cgcggccccc ggacaagggc agcttcccgc tggatcactt aggtgaatgt      180

aaaagcttta aagagaaatt catgaagtgt cttcataaca ataattttga aaatgctttg      240

tgcagaaagg aatcaaaaga atatttagaa tgcaggatgg agagaaaatt gatgctacaa      300

gaaccattgg agaaactggg atttggagac ttgactagtg gaaaatcaga ggcaaaaaaa      360

tgaattttga tgagaagacc cctgggccgt gttcagtggt ctctcaggac ggagggcatc      420

atcctgcctc ttaggttggc tgaggcctgc gtgtggtgtc cttagaaatg ggcttcgaat      480

agaagctcca gccctgtggg ggcgtctcct gggtagggag tggcgtcccg ttttccctta      540

ggagggtgtt tctgcattga acccctgagt gggacggcgt tcccggcaaa gctgggaggg      600

aggcgagcgt ggggcaagac ccttgtcttc gaggccgggg ccctcttgta tggggcggtt      660

ttatgttgca gtcctctgat actttctgag ttcaaagagg taaatgtata aatttcagtc      720

ccttctgaac acagatatca tcagaaaatt accattccct agcaggatgt tttcgtgttt      780

gtattcgtat atgccagttc atttcctttg aaaaaaaaaa aaagtggaac acaaagtagg      840

aagtgagaac cttctggctt tggatggatt gacttcttga ttctttctgg ttttgcctga      900

acaccaagta gcttcataat caaagggtca ttttctggtt tgtatcagac cgtatttata      960

aagttgggta tttaatttca gtaactcctg tattttaaca gaaaaagaac ctgagtccat     1020

ttgcagttag gctcgcacca gctgtcttct gtgccagcca gctccgcccg agaccccggc     1080

acgtgttcgc agcacagcct ggcaggggcc ctgagcggag ttctcagccc gtctgtgcca     1140

aagttgcctg tgggtcacgg aaacccggcc catgtccacc cagtgcgtca ggccagccgg     1200

ggcccaaacc tgtggatgga acgcaggtgc ctgcacatct ggggcctcag ccagacctgt     1260

ctccttccca ggcactgtcg gaaaggggct ggctcctgtc tggtcagtgg aggatggtgg     1320

caggagacgg ggtggggagg tccaggtcac gtcctctctg gcgaccctgg cagtggctgt     1380

ctccaagccc tggcaggtgg ggccaccaat ctggccgacc tcaggctctg ggaaacaggc     1440

tgccctcgtc cctctgcctg tgggtggctg aggcttctca gcccatctcc agttctctgc     1500

agcaaaggcc ctctgtttct gtcctgcagt ggtggccctt tcgtggttaa acatgtccct     1560

cccctcctca cagaactgag tacctattgc ggctgggccc gcccaaccct gtgtccctgc     1620

acccatgggt tctaccacct gattcggctg cagctgtcac tgtcccgtgt ctgctctctg     1680

tcaggcctct gagtgctgca gacgtattaa catatcaccg ctagttgatg gaaagtcttg     1740

tttcttatta gaatattttg tgtaggcaca gggttgcccc agcactgtct atagcaaccc     1800

cagtgtcctc acagtgcacg tgagccgtga cgcagccacc gtggagtcgg cgctgacgcg     1860

gtgtggccac gtgccatgag ctcgccaacg cagtgcggct atatggcgtg agcttactgt     1920

gaagtggaga caggcaggga cacaggaaac tacaaacgag aaatccagaa ggaggagctg     1980

gaactgatgg gcatagccgg ccgcgagccc ctccgagcac ccctgggggt ggagttctgg     2040

ctgtcatggc agagggtttc acatgctcaa aaagtaaatg aaccaggatg tgaggggaac     2100

acaacagacc atgccgacgg agctcccggg cccaggccgg ggcctcttcc catcgcactc     2160

tgacccgccg tcgggagtgc ccaggcccgg gtcgggcctg cctctccgct cgcaccgcac     2220

tctgacccat caggagtgtg gggaagaccg tcgaccaaag gtgggaaaga caggaaagat     2280

actgtactct aagtagtaaa tttgtttttt gcgtggacga ttctgaagct gtattctgag     2340

atggaaaaaa ctagaaatac atcgtggatg atgagagcca ggtgtattga gctcctgctt     2400

ttctaacgta caaaggtaac tggatagaga aacggagtga tcgccctcac ctggccaggg     2460

tgtgctccga gaccccagca ggtgccgaag ccgcggatag tcccgaatcc tgtccaggcg     2520

ctgttttttc ctgtacgtac ctgtgatcaa gtctgagatg tgacagcaaa actgacagaa     2580

cttcgtgctt ccctcttcaa aatgtcacag atgggcactg tgttcttacc ggagatctta     2640

gcaacctcgg catctggctg tttttcttat aggtcaggag tttccacctt ttcccttaaa     2700

ggaagcgctt ggcagcttct ctggtgtgtc tgagtcgcca gcatcaccac tgtcctgttc     2760

tggggccatt cttaagtaaa ataaaagctt cttggaccca agcaccacat caccgcgatg     2820

gctggtctga tcaccgagat ggctgctgag tgcctggcag gcagggtggc gtggatggcc     2880

cgaaacgctg gacggaggga gggttgatgt cccagcagga cggctgctca gaacagcaca     2940

gaatcaaaaa ctcatgaatg gtttatttct ggaattttcc acttagtatt tttggactgt     3000

ggctgaccat gggtaactga aaccgtgtgt aagggggact gttgtgaggg gctgtgcaca     3060

aatgcttccc agctcttgag ggcctggacg cagtgacccg tgcactcagg gtcttggccc     3120

tgataccatt ctgtaaccaa aaggaaccag ggccaggcca gagaaggtat cagatgagct     3180

agagagtgaa gaattgctgg gatgaggaga cttgttgaaa taacacgggg ggatgggaag     3240

gagcatacgg tggccagcct ggggcagtgt gagcgtgaaa ataaacaggc tgggcgcagc     3300

ggctcacgcc tgcaatccca gcactttagg aggccaaggt gggaggatca cttgaggcta     3360

ggagttcaag accagcctgg gcaacatggg tgaaaccctg tctctacaaa acaagaaaag     3420

tcagccgtgc gtggtgtcac ccgcctgtag tcccagatac tcaggaagct gaggcaggag     3480

gatcacttga gccagaggtt aagtctgcag tgagctgtga ttgtaccact gctctccagc     3540

ctgagcaaca gagccggacc ctgtctcacc aaaggaaaaa aaaaaaaaaa aaagaaagaa     3600

aattaattat tgtaatgggc tgtagccctc agaataaatt gatatccagt agtctataca     3660

acataa                                                                3666


<210> 1249
<211> 1605
<212> DNA
<213> Homo sapiens

<400> 1249
cttgtgggtg gaaacgcgct ggctgactgg ggtcggcgtt tagttcagcg cagcgactcg       60

gggacctgga gctgacgcct agacacttgt attagcttta atagaagaga aatggaggag      120

ccatagaata ttaaggatga attcaggaag gcctgagacc atggaaaact tgcctgctct      180

ctacactatt ttccaaggag aggttgctat ggtgacagac tatggggcct ttatcaaaat      240

cccaggctgt cggaagcaag gtctggtcca tcgaactcat atgtcatcct gtcgggtgga      300

taagccctct gagatagtag atgttggaga taaagtgtgg gtgaagctta ttggccgaga      360

gatgaaaaat gatagaataa aagtatccct ctccatgaag gttgtcaatc aagggactgg      420

gaaagacctt gatcccaaca atgttatcat tgagcaagaa gagaggcgga ggcgatcctt      480

ccaggattac actgggcaga agatcaccct tgaggctgtc ttgaacacta cctgcaagaa      540

gtgtggctgt aaaggccact ttgcaaaaga ttgtttcatg caaccaggtg ggactaaata      600

ctctctgata cctgatgagg aagaggaaaa ggaagaggca aagtcagcag agtttgagaa      660

gcctgaccct acaaggaatc cttctagaaa aagaaagaag gagaagaaga aaaagaaaca      720

tagagatagg aagtcatctg actctgacag ctcagactct gagagtgata caggcaagag      780

ggcaaggcac acatcaaaag acagcaaggc agcaaagaag aagaaaaaga agaagaagca      840

caagaagaag cacaaggagt gagagtataa agagtgtagg gggtggttga gagtaagaaa      900

ccaggagcct tgtgccttga gactcctgga aagactcaat agtgagaata tagcctccca      960

ccccattaac ttcgctccca tgggagatgg cttcccctca tgcaacaggc aggtttggga     1020

gttagaggtc aaaagcagct gcctgaatga gttgttgttt ccttatcact cctggtccct     1080

ttgcaagtga accctgcagc tcacccattc attcacccaa cttccttcat tcagcaggag     1140

gtcctattac cctctccagc tgccactgcc agagctggat tcctgtaaag gagtccaggc     1200

tagagccaca gagactgttg tggaggtgag ttcggctgta gttagagtga ttggaccctt     1260

cctattggtc tgtcctgggc caactggtgg gtgatctctg ctgcatccaa catgggagca     1320

gagactggca gcaggagggg ggaacatggt gagaagtggt gctcactttt cccattcctc     1380

ctaacatagt tctactatgc tagaagtggc atccagcggc cacagctaga aaacagtctg     1440

cagtgtgact taacttgtgt attgcattcc agcagaccac tgaaccagac agcgaagcca     1500

agatcattgt tctactttgt atttactact gtgtgaatca gttgattcta cttcaggtcc     1560

ttgcttaaat tcctgtcact aaatggaaat gtgtttggtt ttaaa                     1605


<210> 1250
<211> 2899
<212> DNA
<213> Homo sapiens

<400> 1250
ggcggtagcg gcagcggcgg cggcggcggc ggcggcggcg gcggcggcgg cggcggcggc       60

ggcagcggcg gcggcctggg cccgggcgca gcggcggcgg cggcggggcc tggagccgga      120

tctaagatgg cagcggcggc ggcggcggtg gggccgggcg cgggcggcgc ggggtcggcg      180

gtcccgggcg gcgcggggcc ctgcgctacc gtgtcggtgt tccccggcgc ccgcctcctc      240

accatcggcg acgcgaacgg cgagatccag cggcacgcgg agcagcaggc gctgcgcctc      300

gaggtgcgcg ccggcccgga ctcggcgggc atcgccctct acagccatga agatgtgtgt      360

gtctttaagt gctcagtgtc ccgagagaca gagtgcagcc gtgtgggcaa gcagtccttc      420

atcatcaccc tgggctgcaa cagcgtcctc atccagttcg ccacacccaa cgatttctgt      480

tccttctaca acatcctgaa aacctgccgg ggccacaccc tggagcggtc tgtgttcagc      540

gagcggacgg aggagtcttc tgccgtgcag tacttccagt tttatggcta cctgtcccag      600

cagcagaaca tgatgcagga ctacgtgcgg acaggcacct accagcgcgc catcctgcaa      660

aaccacaccg acttcaagga caagatcgtt cttgatgttg gctgtggctc tgggatcctg      720

tcgttttttg ccgcccaagc tggagcacgg aaaatctacg cggtggaggc cagcaccatg      780

gcccagcacg ctgaggtctt ggtgaagagt aacaacctga cggaccgcat cgtggtcatc      840

ccgggcaagg tggaggaggt gtcactcccc gagcaggtgg acatcatcat ctcggagccc      900

atgggctaca tgctcttcaa cgagcgcatg ctggagagct acctccacgc caagaagtac      960

ctgaagccca gcggaaacat gtttcctacc attggtgacg tccaccttgc acccttcacg     1020

gatgaacagc tctacatgga gcagttcacc aaggccaact tctggtacca gccatctttc     1080

catggagtgg acctgtcggc cctccgaggt gccgcggtgg atgagtattt ccggcagcct     1140

gtggtggaca catttgacat ccggatcctg atggccaagt ctgtcaagta cacggtgaac     1200

ttcttagaag ccaaagaagg agatttgcac aggatagaaa tcccattcaa attccacatg     1260

ctgcattcag ggctggtcca cggcctggct ttctggtttg acgttgcttt catcggctcc     1320

ataatgaccg tgtggctgtc cacagccccg acagagcccc tgacccactg gtaccaggtg     1380

cggtgcctgt tccagtcacc actgttcgcc aaggcagggg acacgctctc agggacatgt     1440

ctgcttattg ccaacaaaag acagagctac gacatcagta ttgtggccca ggtggaccag     1500

accggctcca agtccagtaa cctcctggat ctgaaaaacc ccttctttag atacacgggc     1560

acaacgccct cacccccacc cggctcccac tacacatctc cctcggaaaa catgtggaac     1620

acgggcagca cctacaacct cagcagcggg atggccgtgg cagggatgcc gaccgcctat     1680

gacttgagca gtgttattgc cagtggctcc agcgtgggcc acaacaacct gattccttta     1740

gggtcctccg gcgcccaggg cagtggtggt ggcagcacga gtgcccacta tgcagtcaac     1800

agccagttca ccatgggcgg ccccgccatc tccatggcgt cgcccatgtc catcccgacc     1860

aacaccatgc actacgggag ctaggggccc gccccgcgga ctgacagcac caggaaacca     1920

aatgatgtcc ctgcccgccg cccccgccgg gcggctttcc cccttgtact ggagaagctc     1980

gaacacccgg tcacagctct ctttgctatg ggaactggga cactttttta cacgatgttg     2040

ccgccgtccc caccctaacc cccacctccc ggccctgagc gtgtgtcgct gccatatttt     2100

acacaaaatc atgttgtggg agccctcgtc ccccctcctg cccgctctac cctgacctgg     2160

gcttgtcatc tgctggaaca ggcgccatgg ggcctgccag ccctgcctgc caggtccctt     2220

agcacctgtc cccctgcctg tctccagtgg gaaggtagcc tggccaggcg gggcctcccc     2280

ttcgacgacc aggcctcggt cacaacggac gtgacatgct gcttttttta attttatttt     2340

tttatgaaaa gaaccagtgt caatccgcag accctctgtg aagccaggcc ggccgggccg     2400

agccagcagc ccctctccct agactcagag gcgccgcggg gaggggtggc cccgccgagg     2460

cttcaggggc cccctcccca ccaaagggtt cacctcacac ttgaatgtac aacccacccc     2520

actgtcggga aggcctccgt cctcggcccc tgcctcttgc tgctgtcctg tccccgagcc     2580

cctgcaggtc cccccccgcc cccccactca agagttagag caggtggctg caggccttgg     2640

gcccggaggg aaggccactg ccggccactt ggggcagaca cagacacctc aaggatctgt     2700

cacggaaggc gtcctttttc cttgtagcta acgttaggcc tgagtagctc ccctccatcc     2760

ttgtagacgc tccagtccct actactgtga cggcatttcc atccctcccc tgcccgggaa     2820

gggaccttgc agggacctct ccctccaaaa aaagaaaaaa agaaaaagaa agaaaaaata     2880

aatgaggaaa cgtgttgca                                                  2899


<210> 1251
<211> 1760
<212> DNA
<213> Homo sapiens

<400> 1251
ggcatggcct aagccggtca gctaaggcca tgttaatacg gggctgtccc atctctctgc       60

ggggcgcgac agctggaaga gccgaacgga taagagaaga ggagggcgcg gatggcgtcg      120

gggcgccccg aggagctgtg ggaggccgtg gtgggggccg ctgagcgctt ccgggcccgg      180

actggcacgg agctggtgct gctgaccgcg gccccgccgc caccaccccg cccgggcccc      240

tgtgcctatg ctgcccatgg tcgaggagcc ctggcggagg cagcgcgccg ttgcctccac      300

gacatcgcac tggcccacag ggctgccact gctgctcggc ctcctgcgcc cccaccagca      360

ccacagccac ccagtcccac acccagccca ccccggccta ccctggccag agaggacaac      420

gaggaggacg aggatgagcc cacagagaca gagacctccg gggagcagct gggcattagt      480

gataatggag ggctctttgt gatggatgag gacgccaccc tccaggacct tccccccttc      540

tgtgagtcag accccgagag tacagatgat ggcagcctga gcgaggagac ccccgccggc      600

ccccccacct gctcagtgcc cccagcctca gccctaccca cacagcagta cgccaagtcc      660

ctgcctgtgt ctgtgcccgt ctggggcttc aaggagaaga ggacagaggc gcggtcatca      720

gatgaggaga atgggccgcc ctcttcgccc gacctggacc gcatcgcggc gagcatgcgc      780

gcgctggtgc tgcgagaggc cgaggacacc caggtcttcg gggacctgcc acggccgcgg      840

cttaacacca gcgacttcca gaagctgaag cggaaatatt gaagtccagg gagggagcgc      900

cccgggccgc gtccgccccg tcccacacta cgcccccgcc ccactcccgg ggcctgctaa      960

tctgaggccg atccgggacc ggcctccttg cgtctcccat tcccaagatt gtcccgcctc     1020

tgccaatccc cgccgtcctt ccagcccacg acctgccgcg ccgaggagcg gcatctgtcc     1080

cgtttcccga ttgggtctgt cgtctctctc cgcctagcga cagattcctt ctattaaggg     1140

attggctcgc tgagttctaa gctctaaatg ggtcaactcc tttgttttcc gcctagcgac     1200

aagggatttg ctcgcacggc attggctcca tcccctagtc gctggacagc tctttttttg     1260

attggctcaa atcctgtaaa gggcttgacc agtctctaca tagtcaccgt ccgcttttcc     1320

tgagttctcc ctcccaattg gctccagctt cctgggggcg tggccaagcc ctcctcttcc     1380

cagaattggc ccggggcctt caatttacgt tctttacact acggggactg gggtcgtctt     1440

tgcccacgtc ccgacaactt gttccctgac cccctcaggg atggccccaa actgtccctg     1500

cctctggcac cccctttcat tggttccatc catccccaca acagcctgcc aatcgaagcc     1560

cgtccctgca tccaggatgg taccagctcc cgcccctcgc cccccacctc cacaggtgcc     1620

ttaaagggcc ctcgtccacc caaggtgggg ggcaggggcc ctcactctcc ggccctggtg     1680

tgggggagag agtgaggggt tgggggatcg gcagttggga ggggcgctct gagattaaag     1740

agttttacct ctgagataaa                                                 1760


<210> 1252
<211> 7325
<212> DNA
<213> Homo sapiens

<400> 1252
ggaagcggaa gtgaagggtg cgcttggcgg cggcggcggg agctgcggag tcgggaatca       60

aaacaaaggg cctggggggg gcggggggaa ggcggcgggg ccggaatgtg agcggaggtg      120

gagccggcgg cagagggtgg aagaatgaaa gaaaagaaag atgaaaggat gttgaatcac      180

tttgcatggc tgtatgatgg aaggaaacgg aactgagaac tcctgcagta gaacacgtgg      240

atggcttcaa caagataatg atgctaagcc atggctttgg aaattctcta attgcttttc      300

tcgtcctgag cagacgctgc cacatagtcc ccaaacgaaa gagtacatgg agaacaagaa      360

agttgctgtg gaactaaagg atgtaccatc accccttcat gctggctcta agctttttcc      420

agcagtccca cttcctgata ttcgttctct tcagcagcct aaaatacagc tttcttctgt      480

ccccaaagta agctgctgtg ctcattgccc taatgaaccc tccacttcgc caatgcgttt      540

tggtggtggt ggtggcggta gcggaggtac cagtagcttg attcacccgg gcgcactgtt      600

agactcgcaa agcaccagga caatcacgtg tcaggtaggg tcagggtttg ctttccagtc      660

tgcatcttca ctccagaatg cctcagctag gaacaatttg gcaggcattg caagtgactt      720

tcccagcatg tgtctagaga gtaacctgtc ttcctgcaaa cacctgccct gttgtggaaa      780

actccacttc cagtcatgtc atggtaatgt gcacaagctg catcagtttc cgagtctgca      840

gggctgcacc tccgctggct atttcccctg ttctgatttc acaagcgggg ctccagggca      900

tttggaagag cacatttcac agtcggagct aacgcctcac ttgtgcacca actctttgca      960

ccttaatgtg gtacctccgg tttgtttaaa gggctcactt tactgcgaag actgtctaaa     1020

caagccagca agaaatagca taatcgatgc ggctaaagtc tggccaaata taccacctcc     1080

aaatactcaa cctgcacctc ttgctgtccc tctgtgtaat ggctgtggaa ccaaaggaac     1140

agggaaggag accacgttgt tattggcgac cagtctaggc aaagctgctt caaaatttgg     1200

gtcaccagaa gttgcagtag ctggacaggt gctagaaaac ttacccccca ttggagtttt     1260

ttgggatatt gaaaactgct ccgttccctc tggccggtca gcaactgctg ttgtgcaaag     1320

aatccgtgag aagtttttta aaggccacag agaagcagaa ttcatctgtg tatgtgacat     1380

cagtaaagaa aacaaggaag ttattcaaga gctgaataat tgccaggtaa ccgttgccca     1440

catcaatgct actgcaaaga atgccgctga tgataaactg cggcagagtc tccgcagatt     1500

tgcaaataca cacactgctc cagccacagt ggttcttgtg tcaactgatg tcaattttgc     1560

attggaactt agtgacctga gacacaggca tggtttccac attattttgg tccataaaaa     1620

ccaggcctca gaagcactgc tgcatcatgc taacgagctg atcagatttg aagagttcat     1680

ttccgacttg ccccccaggt taccactaaa aatgccacag tgccacactc tgctctatgt     1740

ttataaccta ccagcaaata aggatggcaa gagcgtcagc aacaggctca gacgcctgtc     1800

cgataattgt ggtgggaaag tgctgagtat cacaggctgc agtgcaattc tccgcttcat     1860

aaaccaagat agtgcagagc gcgctcagaa gcgaatggaa aacgaagatg tctttgagaa     1920

aaaagataaa gaggagactg tattccaagt gagttacccg tctgctttta gcaagttagt     1980

tgcatccagg caagtcagtc ctctgctcgc atctcagtct tggtcttcta gagcatcccc     2040

gcttgctttc aacattgcaa attcgagcag cgaagccgac tgcccagacc catttgcaaa     2100

tggtgctgat gtccaagtca gcaacataga ctacagatta tcccggaagg agctgcagca     2160

gctcctgcag gaagcatttg ccaggcatgg caaggtgaag agtgttgagc tcagccccca     2220

tacagattat caactcaagg ctgttgtgca aatggaaaac ttacaagatg cgatcggtgc     2280

agtgaatagc ctccacagat acaaaattgg cagcaaaaag atcctggtct cacttgccac     2340

cggggctgcc agcaaatcac tctctttact gaggtttgga cacaagttga atgtgtcaga     2400

tctatataaa ttaacagaca cggtcgcaat ccgtgaacaa ggaaacggac ggctggtgtg     2460

tctcctaccc agcagtcagg cccgccagag ccccttgggg tcttcccagt cacacgacgg     2520

ctcctccacg aattgcagcc caattatatt tgaagagtta gaatatcacg agcctgtctg     2580

cagacagcat tgttccaata aggatttcag ctttccagat tgttacattg cagagtttgg     2640

cgatctagaa gtagtgcaag aaaaccaagg aggtgttccc ttagaacact tcattacctg     2700

tgttccaggt gtaaacattg ccactgctca gaatggcatc aaagtggtta aatggattca     2760

caacaagccc ccgcctccca acactgaccc ttggcttctg cgttcgaaga gtcctgtagg     2820

taacccccag ctgatccagt tcagtagaga agtgattgac ttgctgaaaa gccagccatc     2880

ttgtgtcata cccatcagtc atttcatccc atcctatcac catcattttg caaagcagtg     2940

ccgagtgtca gactacggat actccaagct gattgagtta ttagaagcag tgcctcatgt     3000

attgcagatt cttggaatgg gctccaaacg tctgctgacc cttacccaca gggcccaggt     3060

gaagcgcttt actcaggatt tactaaaact tctcaaatcc caggccagca aacaggtcat     3120

tgtgagagaa ttctcacagg cttatcactg gtgtttctca aaggactggg atgtcactga     3180

atatggtgtt tgtgagttga ttgacatcgt atcagagatt ccagacacaa ccatctgctt     3240

gtcccaacaa gataatgaaa tggtgatttg tatccccaaa agagaacgca ctcaggatga     3300

aatagaaagg acaaaacagt tctccaagga tgtcgttgat ttgctgcgtc accaacccca     3360

tttccggatg ccctttaata aatttatccc ttcttaccat caccactttg gccggcagtg     3420

caaacttgcg tactatgggt ttaccaaact acttgaactt tttgaagcca tacctgatac     3480

tttacaagta ttggaatgtg gagaagaaaa gatccttact ctgacagagg tggagcggtt     3540

caaagctcta gctgcccagt ttgttaaact ccttcggtcc caaaaagata actgccttat     3600

gatgacagat ctccttacag aatatgctaa aacttttggt tatacatttc gtctccaaga     3660

ctatgatgtc agttccattt cggctttaac tcagaaactc tgccatgtcg tgaaggttgc     3720

cgatatagaa tctggcagac agattcagct gatcaaccga aagtctctgc gatctctcac     3780

tgcccagttg ctggtattgt tgatgtcttg ggaaggaacc acccatcttt ctgttgagga     3840

gctcaagaga cattacgaaa gtacccacaa cactcccctt aacccctgtg aatatggatt     3900

catgaccttg accgaactgc tgaagagcct gccatacttg gttgagaccg ctgcagcctt     3960

cgacttgcaa atagaactga agtttgctgg aggctatagc cttctcttgg aggaaatcct     4020

tgaatatatc cctcctcctt ttctttctcc tcttccttct ttccttcctc ctcctccttt     4080

cttcttcttt gtcttttttg tcatcttcat cttcttcatc tttgtctttg tccaattcgt     4140

cgtcttcgtc ttctttatcg tcgtcttcgt cttcttcatc gtcgtcttcg ttttcactaa     4200

tgataagatg gaagaatgtg tgaagctcac aagtctgtat ttgtttgcaa agaatgtgcg     4260

gtctttactt catacttacc actaccagca gattttcctt catgagtttt ccatggccta     4320

taccaagtat gtcggagaaa ctctgcagcc caagacctac ggccacagca gcgtggagga     4380

gctcttggga gcaattccac aggtggttgt tcagtttctg caaaaaaatg gcaaagagct     4440

ctcatgtgag aactacctta atttatatgc caaagctggt cgtttgagtt cactcagtct     4500

ctcccctgcc aatcatgaaa accagccctc ggagggcgag cgcatcctgg aggtgcccga     4560

atcgcacaca gcctcggaac tcaagcttgg agctgacggc agtgggccca gtcacacaga     4620

gcaggagctt ctccgcctga ccgacgactc ccccgtcgac ctcctgtgtg cgcctgtccc     4680

ctcgtgcctg ccgtcccctc agctgagacc agaccccgtt atcctccaat ctgctgatct     4740

cattcagttt gaggagcgcc ctcaagagcc ttctgaaatt atgattttaa accaagaaga     4800

aaaaatggag attccaatac caggaaagag caaaactctg acctctgact ccagctcgtc     4860

ctgcatctca gcagctgtcc ccgtgcctcc ctgcccctcc tcggaaacct ccgagtcact     4920

gctcagcaag gaccccgtgg aaagcccggc caaaaagcaa cccaaaaata gagtcaaatt     4980

ggcagccaac ttttccttag cacctataac caagctttaa ctcccatttg gaatatagaa     5040

ttaggatggg aaaacactgt ctgattctgc acacaaaagt gggtttcaaa aatacatcct     5100

tttctgtgtc atgaaaaccc cccgaagcca ttgacttcat cttacctgtg ttctatcatg     5160

tttttctttt ccattgaaca cagctttgag ctgaagtctt tcttttcttc ttcctttttc     5220

tttctttttt caattatttg aagaacttgt ggcatttgtt aaagaatcct taatatattt     5280

taccaaattt ttagtaacta ttatgaaata caatggtgtt ccaaaagaag aaagcactaa     5340

aaactcaact agcaggaagc ggttttgctt ccattgagcc acgtcggtgg tgtcatccta     5400

catgtagcat aatagagtct ctcagccttt gcttactggt gtttccgaca gtattaaccc     5460

agtgcgtggc atgtctttga agcaaagcct gtcccgctag cctgtgtgtt cacacaccaa     5520

aggagaaggg taggcgaggg gttcggagtg tattttcagg ttggaatgtg aaggttcctg     5580

gcttccatgt gacttgtaag tgtgccttgt tttttattta aactatgtct gtagttgaca     5640

aaagtggctt catcacaaat ttttttaaac gtttctactt tggggttcca tttaggagct     5700

ttctagaaag ttgaggatgt ttgaagcttc ccttctgtgt tccagtttga tatgggttag     5760

gttaaggaaa aggagatggt ctcgatgtca tggatttaaa gtcagcattt ggattacaac     5820

acacattatt gtgtgtcgag aggcagcatt ggaaagagcc tgattttcta aaatatgcat     5880

caagtgcata aattacaaat cagagctgag tggggaggtg cttcagcagc agcgggatca     5940

atacgatttc cactgggaag agacaggaat tctacctaca cataggaagg ccaaggttga     6000

tccacttaac cttgttattg taattttaaa gctggtatcg gtagctggga agctttatgt     6060

gtgtgtatgt cagctcagca tcttttaatc gtgtctgatt ttactctcgt tacttctcgc     6120

tgttggaagc atctctgggt ttcttgtggc gtctggtgtg gaatggcctt cctctctagg     6180

tgcctgaggt gtccgctgac gggtggcctc tcacccccct ctagagaaac ctgacattta     6240

caatggattg tatttgtccg gcaaaaaagg cggattcatt catagagcag aaagaacctg     6300

ttggcgtaag gtcttccact agttagatgg tttcttttgg ggaaatgttt atatttggta     6360

acttctagaa agccagaaaa tggactctga tttcatagca ttttgataaa atgccacaaa     6420

ataagggcta tagagagatt tttacaagtc agattttttg ttccccaaat cttttaaatg     6480

aagccagtga ctcccagttc tcaacacatg gccccagtca agacagaaca ccatggaaaa     6540

aaccctgtaa gtattatggc actctccgaa tcctcctgaa ggcatttcct ctacagacat     6600

agtgttacag gaagtgaaat gcaaatgtgc aatttttttt aaaggagctt ttaaacaaag     6660

taataataat tggtgttgag aacatcagtt gccttattct aagatttcat aaggctgagt     6720

ttgcacgctt ggacttcagt tctgctagca tgtaaagagt ggtggacttt aaaaccgtaa     6780

gaggtatcat tacaagtcac ctggaacaga ctcaaagaac aggttctttg ggcaacagac     6840

aaagaagaat caagttctgt gctgtcccgt gagtgtgtct gagtaccatt cactggagtt     6900

gctgcttagg tctgggacgt gtgtgtgact cttaacaatt gctgtctgaa aatgagagag     6960

aagacttcgg aagcacattg tgttcataat gtactccaca atggccagtc caattgctat     7020

ctattttttt atccagaggc ttaattaaat gatgtggtaa aatgatgttt gagcattaag     7080

acaatgtaat tctttatttc tgggtggaaa gatataccgg attaaattta tctgtttaaa     7140

aaaatgacaa aagttatcac caaaaccccc tttcccatct tgcactgttt gttttggatt     7200

gggtttgggg gaaagagatg tttttcttag ttgtctactt tgtttgaaca cttttgttgt     7260

ggttcaagtg ctgttttgtg tgttgggacc aaacagttgt caataaactt tacaagcgag     7320

catct                                                                 7325


<210> 1253
<211> 7900
<212> DNA
<213> Homo sapiens

<400> 1253
gacggcggct cggcgatggc tctcccgcag gcgcagaaac ggctgctggg cagctgatgg       60

gcaggagctt accaggctgg cttgctctga gctgcggtta ctgtgtccag gccccgggtt      120

ctcagaactg tcatacataa agtacacaga aatgaagaga aaagtcgtga atactcacaa      180

gctgagattg agtcctaatg aggaagcctt cattttgaag gaagattatg aaagaaggcg      240

aaaactaaga ttgctacagg ttcgagaaca agaaagagat atcgccttac agataagaga      300

agacataaaa cagaggagaa atcaacaatt tacacgtttg gcagaggagc taagggcaga      360

atgggaagaa tcacaaactc agaaaataca gaacttggaa aaactgtatt tggcaagttt      420

aagaagtatg ggagagggac atcgacaggc caaagaaaat gaacctgatt tggatgcttt      480

ggcacagcgg gcagcagaaa ggaaaagaaa agcagatttg aggcataaag aagccttgaa      540

agtacagaaa aatcaaaaag aaatattact gaaacaaaaa acctggcata taaaagctcg      600

aaaggaagca ctgcttgtgg aaaaagagag atcagccaaa attacaagtc tgccacctcc      660

tcctccaact ctttttgaga acatcgaagt aaaaagaatt tctgcagtca aaaccaatag      720

ttctacctac catcatcttc acacttttgt gaatagagag acagacacaa aacggccaga      780

tgctcgtttg gctgctgaag aggaagctaa acgattggaa gaactacaaa aacaggcagc      840

acaagagaga atggaacggt ttgaaaaggc acatgtacgg ggattccaag caatgaagaa      900

gatccatttg gctcaaaatc aggagaaact aatgaaagaa ctcaaacagc tacagcaaga      960

ggacctggca cgtaggagac agactgtagc acaaatgcca ccacaactag ttgaacttcc     1020

atacaaacgc agtgaaatga aagaagactg gcagagagaa ttggaatttg cctttgaaga     1080

tatgtacaat gcagacagga aggtgaaagg gaatctgatt ctgcaccttg aaccagagcc     1140

cttgcccact gtgactaatc agatccaaga tgaagagctg gacctttcaa tggaacaaga     1200

aaatttgggt gcagctgaag accttccagt gacagaagct gaaatatgtt ctagtgaaac     1260

agatgttccc ttggtaatga agacccaaca gattccttca aaagttcttt ttaaaaaatt     1320

attaaataag atccgaagcc aaaaatctct ctggacaatt aaatctatgt ctgaggatga     1380

aagtgaaatg attacgactg ttagtgaaat tgagagtaaa gcaccaacgg ttgagtcagg     1440

aacaattgcc agcaaagaga gaacgttatc ctctgggcag gaacaagttg ttgaaagtga     1500

tacactaaca attgagtctg gaccacttgc tagtgaagat aaaccacttt cgtgtggtac     1560

aaactctgga aaagaacaag aaataaatga gactctgcct atcacaactg tagctcagag     1620

ttcagttcta cttcatcctc aagaagcagc agccaggatt agaatgtcag caaggcagaa     1680

acagataatg gaaatagaag agcagaagca aaagcaattg gaattacttg aacaaattga     1740

acagcagaaa ttaagattag aaactgactg cttcagggct cagctggaag aagaaaaaag     1800

aaaaaaaact caaccgactg gggttggcat tgctccagca tcatgccctg taatttctga     1860

tgaagatagt cataggcaga tgattcgtaa ctatcaacat cagcttttac aacaaaacag     1920

gttacacagg cagtctgttg aaacagccag gaaacaatta cttgaatatc aaactatgtt     1980

aaaaggaagg tgcccatcgg tgtcagctcc atcattgata actgattctg ttatatcagt     2040

gccatcatgg aaatctgaga gaccgactgc tatatcagag cattgggatc aaggtcagag     2100

actcaagttg agtcctaaca aataccaacc catacaacct atacagacct ccaaattaga     2160

acaagatcat tttcaggtag cgagacaaaa tcactttcca caaagacagg tggaaacaac     2220

agaaacatta cgcgcttcag atattttaac caatcaagct ttagaatcac aagaacatct     2280

aaggcaattc tctcagactg aaacacaaca gagagactat aaattggtcc ccaaagattc     2340

tgagacactt tcaagggctt tgtcacatga caggcagcta atatcacagg atgctagaaa     2400

aatatctgaa acatttgggg caacaacttt tcaaagttta gaatcccaac aattgttctc     2460

agagaatagt gaaaatatat cttaccattt aactgaacct tcttcatttg taccactggt     2520

acctcagcat tcttttagtt ctctgcctgt taaagttgag tcaggaaaaa ttcaagaacc     2580

cttttcagcc atgagcaaaa gtacagtttc cacaagccat tctataatca gccaaatgca     2640

tgataggcct ttgctgccgt cagagaatat cacagcccag caaggtaata tgaaggccct     2700

ccaagaacag ttagacctac agaagaaagt tcttcaggca actcaggaag ctcaggaaca     2760

gttgcttttg tgcaaacaga aagaagtgga acagcaaacg ggcctctcgg tattccttcc     2820

cttggtaact ccagattcat ctgctttatt gccttctgcc aaagcagatt tggggagaat     2880

ccaggaatct tcaccaacca agaataatat tgcagtttcc tcagaccatc atgtgatctc     2940

acaacttcag gataagcgtt tgagtctttc acagcctatc ctatcacagc aaaataattt     3000

taaatttctc caagagcagt tgaatattca gaaggatagc cttcaggcta ggcgagaagc     3060

ccaggaagta ttgtatgtac ataaacagag tgaattggat agaagagtat gttccgaaca     3120

ggctgagccc tctttcccat ttcaggtagc tcagcataca tttacttcac taccatctgc     3180

tgatacaaaa tctggaaaaa tacaggagca acattcatct aagagcgaga aaggacttgt     3240

ttcatgccaa tctgacatcc ccatatctca ggatgggtct ttgagtttcc tacagcagtt     3300

cctacctcta catgatagtt tgaagttgct ccaagaacag ttgactaaac agagggatac     3360

tcttcaggct aggcatgaag ctcaggtgga attactttta catagacaaa gagatttggg     3420

ggacagtaag tctgggctgg tgagctcttc atcctcacca gtggttgttc agcattcagt     3480

tgcttcacaa gcttctgcta aagctgagcc taggagaatt caggagcttt atttatctga     3540

gaaggagaat gtaggtccct cctgtcattt gataatccca acatttcagg ataagtctct     3600

tagttttcca cagcatagcc tggcacagca agaaaatttg acaatactcc aagaacagtc     3660

acaaatacaa agggtaatac ttggtgctaa agaaggaact caggaatttg tacacacaga     3720

aagtgaattg gagaaaagaa tttcttctga acagactggc acctcctcat ccctttccca     3780

ggtggatgaa tctgagagat tccaggaatg tatatcaatc aagagtgaca gtaccattcc     3840

cttaagccat cctaagatcc caagatgtca ggaaagactt ttgagagttt cacaacatat     3900

gctacctcta caagataatt tggaggaaca ccaagcatgg ctagacactg agaaagaagc     3960

ctttcatttc agccagaaaa cccaagaaaa tacatcttct gaacaaactg gttcatcttc     4020

attcataccc cagttggtac agctttcatt tacttcgtta gcttcagctg agtctggcac     4080

aatcctggaa cctcttttta cagagagtga aagtaaaatt ttttcaagcc accttcagat     4140

cccacaattg caggataggc ttttgaggat atcgcaactt atccagcctc aacaagataa     4200

tttgaaggca cttcaagaac agttagctac acagagagaa gccatcattc tagctagaca     4260

agaagctcgg gaagaattac ttttacatca gagtgaatgg gagggaagaa tatctcccga     4320

gcaggttgac acctcttcct tacccctagt accacagcat tcattcgcct cattacctct     4380

taatgaatct gaaagaaacc aagaaccatg ttcaattaac agtgataata tagtatcctc     4440

aggtcactca gagataccaa cattgcctga tgggctgttg ggtttatcac atcttgtttt     4500

acctcaacaa gataatttga ttgcacttga agaacacttg catgcacaga cagatttcct     4560

tccttctatt gagaaaaccc agaaagaatt ggttttgtca aaaccatgta aatttgagga     4620

aaaggtatct tctgagcatt ttatccagtc tcaccatggt gatttgcagg cacttcaaca     4680

gcagttagat acacagaaga aagccattcg atctatacag gaagtccaag aagaattgct     4740

tttgcaaaga ttaagtgaat tggagaaaag ggtatcatct gaacaagttt gctcctcttc     4800

atttgtatcc caggtgcctg ttgctgactc tgaaagaacc cagaagtctt tcccaaccaa     4860

aagtaatgat actcttccct caagtcatcg tgagattcca agattacagg atagactttt     4920

gagtttatca aagcctattc tgcctcagca agataatatg acagcacaat tggatgcaca     4980

aagggaagtg atgtattctt atgagaaacc ccaggaagaa ctgtctttaa acaaacaaag     5040

aaagttgaac aaaagtgaat ctgctgagca tactatcccc tctttgtttc tacccaagga     5100

aacagagcat tcgtttattc cactaccttt tgcagaagct aaacctaaaa gcacttgtga     5160

attgtattca tcccagaatg aacatgcagc ccccccaagt aatcctgtga tcccagggtt     5220

tcaagataga cttttgagtt tttcacagtc tgtcttaact cagcaagata acttgggact     5280

tcagaaacag ttggatctac aaagagaagt tctgcattat agccagaaag cccaggaaaa     5340

attgcttgta cagagacaaa cagcattgca gcagcagata cagaaacatg aagagacttt     5400

gaaggatttc tttaaagaca gtcagataag taagcccaca gttgaaaatg atttaaaaac     5460

ccagaagatg gggcagctca gagactggtt tcctaataca caagacctag caggaaatga     5520

tcaagaaaat attaggcatg cagataggaa caactctgat gataatcatt tggcttcaga     5580

agatactagt gccaagcaaa gtggtaaacc aggtatttat gaagacagag accccctgcg     5640

agtctcaata agccgagaac aaagtttctt tgggagccca ctggcccatg atccgtttag     5700

ttgtcttcaa ctggttggcc aagagaatgt ctgtggtgat gactatgatg aagcagttaa     5760

gctgaaggaa tctgttgttg aaaatcatgc agtgttaagt tatgctgtgg aggaagaaca     5820

tgcatatttg ggtccaactg tgaagccaga tgataaggct aaaacactgt cttatgaacc     5880

attatcttca gcaactgttt ccactgggag ccttttaagt tatgaaaaca cagatttgag     5940

ccttacagat ccagagtcat tttcagagca catggatgat agcaagcaag aatctaccac     6000

cagtaaagaa gaggaaacaa atattataag ttccatagtt ccttcaacac aagatattta     6060

tcagcggcag aactcttcag acgttcataa atctctgttg cctgcagtgg atgaaactac     6120

atgtggtcac acacactttc agcaaatgat agacaagtac attaatgaag caaatttgat     6180

acctgaaaaa acagatttgc aagaattgga acacattttt cctaatttgc atcatcagct     6240

gtttaaaccc ttagaaccac atccagattt tgacttatca tcatcatcct ctgggatttc     6300

tccagacaac agagactttt accagagatc agattcttca tctgaaagcc actgtgctac     6360

tggattatcc aaaagtacag tttatttcac agcactgagg aggaccagca tgcattcttc     6420

tcttaacaca agtccgaatc aacaacctga cactaacttg gctcatgttg gagctcacag     6480

ttttgctaca gaaaatatta ttgggggatc tgaacaatgt tttgaacagc ttcagccaga     6540

atattcttca caggaggaga gccagcatgc tgatctacca agtattttta gcattgaagc     6600

aagagattct tcccaaggca tgaaaaatca gaactatccc tctgaagaac atactgaaat     6660

attacaaaac aagaaaaaaa ttgttcattt ccagctttct ataggaaact taagttcagt     6720

ctacagttca tctgatgaag ctaatgtatt tgatcagtta aatgtacagc atagcactcc     6780

atgtggttct aactctagtg agtgctcaac aaaacaccaa ctagaaagca gaaaggaaag     6840

tatgggcttt gaagaactat caaaaagagg ggttgttaca atgttacaaa gtcaaggact     6900

cattgaagat aataaaaatg aaacctgtag ggttttagac ataaatccac aggtagagga     6960

aactgactct cgattatgtg taagaacagt ggagatggga acttcaattc aggcaccata     7020

ttccttaact actcaaaatg aaaaatattt tgagaattca gctgaaacag acattccaaa     7080

aatcaccaaa aaactatctc aactaggaga atcagagctt tttgcaagtt ctggatcatt     7140

ttcattacag agctctatac cagtctggga aacagaaact ggccatggta taatggaaga     7200

accagaactt actttaataa gcaccactga taccagtatt gctgaaatgg attttgcaaa     7260

tttaacccta gaagagaaga gcgagaatga agcaaaatgc ttctttcagg tgagtgagtt     7320

tctgcctctt gtatcagcaa cagaagcctc agattatcca gctgtatcag aactttccat     7380

agaaaaacca aggacagcat ctacagaaac ccctcgcagg cttacacctg taccagggag     7440

cttacaagaa gcatttataa agaggaaaaa atcatttatg gagagatccc accagaggca     7500

gaaagaaata aggaataaaa ttcatgtctc tgaaaattct caaatcaaaa cagttaaaga     7560

gaaaccatct ataagttcat ctgtgagtcg tctaaagggc gtgaataaag tcagagcatc     7620

ttttcctgaa gacagaaaga ctacacaggc tctaaggcac caaaggggtc taaggttata     7680

caatcaacta gctgaagtga aacaacaaaa ggaagaaaaa acaaaacaag aagcttatgc     7740

ccaaaacaga gcaagggcaa aagaattcca taagaaaaca ctagagaaac ttcgagccaa     7800

aaatacatgc tgactttcta gaaatagtgt aaaggttttt taattgtgta tatgtagcat     7860

tagacaaaat tatttaaagt caataaattg ttattcgagg                           7900


<210> 1254
<211> 899
<212> DNA
<213> Homo sapiens

<400> 1254
accggggagc caggtacctt ccgcgagacg tcgaggggcg agtcctagtc tcttttctcc       60

gcactggaag acttgaacac ttccttctct gcagcaaagc acctgctctg agtggccatg      120

gggaagcgat acttctgtga ctactgcgac cgctccttcc aggacaacct ccacaaccgc      180

aagaagcacc tgaacgggct gcagcacctc aaggccaaga aggtctggta cgacatgttc      240

cgagatgcag ctgccatctt gctggatgag cagaacaagc ggccctgcag gaagtttcta      300

ctgacaggcc agtgcgactt tggctccaac tgcagatttt cccacatgtc agagcgagac      360

ctgcaggagc tgagcatcca ggtggaggag gagaggcgag ccagggagtg gctactagat      420

gctcctgagc tccccgaggg ccatctggag gactggctgg agaagagagc caagcggctg      480

agctcagccc caagtagcag ggctgaaccc atcagaacca ctgtcttcca gtaccccgtg      540

ggctggccac cagttcagga gctgcctcca tccctgcggg cacccccacc tggggggtgg      600

cctctgcagc ccagagtcca gtggggctga gccccttgcc cccgactgac ccccacgtgg      660

tcacttttct catcagtcac aataggaagc caagcccggt tcctgctacg ccccatggag      720

gctccgagac catctgccca gcctcactga ggctcaggac acggccacac caagtgcagc      780

cctcgtcctg ggtctgcacc gggcagctct cccctcactc tcctccacct gcccccctgc      840

ttcttaagaa gatgggggag aaaacttcca aatgtttata aagaaagtct gtcaccaca       899


<210> 1255
<211> 4808
<212> DNA
<213> Homo sapiens

<400> 1255
aggttcaagt gcgcatgtgc gcgaggagtc gctcgggcac ttattgagcg ccgactgtct       60

acgggcggcc gggggtgatg ggcagaggct tcagtgtccc cttcgcctcc gcaggagagg      120

agaggcagca gcatggcgag tgtcctgtcc cgacgccttg gaaagcggtc cctcctggga      180

gcccgggtgt tgggacccag tgcctcggag gggccctcgg ctgccccacc ctcggagcca      240

ctgctagaag gggccgctcc ccagcctttc accacctctg atgacacccc ctgccaggag      300

cagcccaagg aagtccttaa ggctcccagc acctcgggcc ttcagcaggt ggcctttcag      360

cctgggcaga aggtttatgt gtggtacggg ggtcaagagt gcacaggact ggtggagcag      420

cacagctgga tggagggtca ggtgaccgtc tggctgctgg agcagaagct gcaggtctgc      480

tgcagggtgg aggaggtgtg gctggcagag ctgcagggcc cctgtcccca ggcaccaccc      540

ctggagcccg gagcccaggc cctggcctac aggcccgtct ccaggaacat cgatgtccca      600

aagaggaagt cggacgcagt ggaaatggat gagatgatgg cggccatggt gctgacgtcc      660

ctgtcctgca gccctgttgt acagagtcct cccgggaccg aggccaactt ctctgcttcc      720

cgtgcggcct gcgacccatg gaaggagagt ggtgacatct cggacagcgg cagcagcact      780

accagcggtc actggagtgg gagcagtggt gtctccaccc cctcgccccc ccacccccag      840

gccagcccca agtatttggg ggatgctttt ggttctcccc aaactgatca tggctttgag      900

accgatcctg accctttcct gctggacgaa ccagctccac gaaaaagaaa gaactctgtg      960

aaggtgatgt acaagtgcct gtggccaaac tgtggcaaag ttctgcgctc cattgtgggc     1020

atcaaacgac acgtcaaagc cctccatctg ggggacacag tggactctga tcagttcaag     1080

cgggaggagg atttctacta cacagaggtg cagctgaagg aggaatctgc tgctgctgct     1140

gctgctgctg ccgcaggcac cccagtccct gggactccca cctccgagcc agctcccacc     1200

cccagcatga ctggcctgcc tctgtctgct cttccaccac ctctgcacaa agcccagtcc     1260

tccggcccag aacatcctgg cccggagtcc tccctgccct caggggctct cagcaagtca     1320

gctcctgggt ccttctggca cattcaggca gatcatgcat accaggctct gccatccttc     1380

cagatcccag tctcaccaca catctacacc agtgtcagct gggctgctgc cccctccgcc     1440

gcctgctctc tctctccggt ccggagccgg tcgctaagct tcagcgagcc ccagcagcca     1500

gcacctgcga tgaaatctca tctgatcgtc acttctccac cccgggccca gagtggtgcc     1560

aggaaagccc gaggggaggc taagaagtgc cgcaaggtgt atggcatcga gcaccgggac     1620

cagtggtgca cggcctgccg gtggaagaag gcctgccagc gctttctgga ctgagctgtg     1680

ctgcaggttc tactctgttc ctggccctgc cggcagccac tgacaagagg ccagtgtgtc     1740

accagccctc agcagaaacc gaaagagaaa gaacggaaac acggagtttg ggctctgttg     1800

gctaaggtgt aacacttaaa gcaattttct cccattgtgc gaacatttta ttttttaaaa     1860

aaaagaaaca aaaatatttt tccccctaaa ataggagaga gccaaaactg accaaggcta     1920

ttcagcagtg aaccagtgac caaagaatta attaccctcc gtttcccaca tccccactct     1980

ctaggggatt agcttgtgcg tgtcaaaaga aggaacagct cgttctgctt cctgctgagt     2040

cggtgaattc tttgctttct aaactcttcc agaaaggact gtgagcaaga tgaatttact     2100

tttcttaaaa aaaaaaaaaa aaaaaaaaaa aaagagtttc tggctgatgg gtgactcaga     2160

gtgcaggact gcctggccgt ggggcagagg ggtttgccct tctcggaggg tacctcctgt     2220

tccctgtctg agcatcctgc atggaagtca aaggaaatcc ctttcttggt gacgacttaa     2280

atctgggttc cctcagacat tgggttgcac cccaacaaat attaaatggc ttcttcttaa     2340

agcccagaga aagaggtttt ttaaaagact gtcgccaaat agctgagcca aaaggctgat     2400

cagaattcac tttttggaat gtggcagtta aacactacct tgatcattct ctcctctttc     2460

ctcgaggaac tcctggaggg tttgagcgtc tggaaactct ctgctctgac ccgaggaagc     2520

accctcctga cgccgccttc ctccggttat tgaaaggacg cctcagaaat gctttgtttt     2580

cttttacgat gtattcagaa gcctttactg attaaagttt tcttttattt gggtggccgg     2640

gagagaccca gggaggttct ggaggttcct ttctgtctcc tggccccacc agggatttcc     2700

ccatttctgt ttgctgcctg aaagcaggat gaggaaggcc aaggagagtc cttgcacccg     2760

tgagcgtcag gatgaggaaa tgacaggagg aagacgtggg tttgggttag tggctgctgg     2820

cgttttggcc cttggtgttt ctggagcctc cagggatcta ggggagcctg ggctgcgtgc     2880

atgtcgataa gcagagctgt tcttggggag aaggagggag gtctcgggag tgtagcacca     2940

tgccaaccag ccctgcgcga agacagagtg agccacgccc ggatggcagg gcatgtttct     3000

gttttggtgt ctcactttcc tcccagcgtg acttatttgg ggattcctca gggcctactg     3060

gaatgtgact gcccactgcc cagctgcctc gggtacaagt cctggcccta tgtcccagct     3120

gtcaggggct cagggaatcc tacccagcca cctgtcctgg gatggagtgt cagcatccac     3180

cccttggttg tcatcgaggc cgccctccca gtcctgggtg aagatatttg ggccaccagg     3240

gctcccttgg ccccttcacg taggaaatag acacgtgctt tttaatgcag gacactttga     3300

gtgttacaaa atctgtagac ctggcagtag ggtcatgatg ttgggaaggg tgtagtgccc     3360

taggttggtg acagaaggga cagacacttg tgcacaggtg tctttggtga tggggttttt     3420

ttttttataa cttagtaaaa aaaaaaaaat gtatgtggaa ttctgtctct tggtaaagct     3480

caaagccagg ctagcctgag gtggcgcagg gctctccttc ctgtcccttc gatctccttg     3540

agaattaaga gctggcagct gctgatggtg tttcccaacc cccctcactt cccaagacaa     3600

cccccagctt caggtcctca tggggagggg agggcacgtt cttgacacat gggaacttcg     3660

ctcaggaggg cctccccttc ccctctccct cagagttttc actgccgtct cgtctttaga     3720

aagctgtttg aattcccccc gcccccagtt tggaccgtgt agatataact ggatatacgg     3780

atttttctct ttgtgcaggc ttcttatgcc gttggtatac agggcaggaa agagaggaat     3840

aaagggagag agcagtgtgg aaaccacggt ggttttgctt tgttcttact aggttttggt     3900

gccaccttcc ctgcctgcgc ttgtgccccc tctcctcctt ggcactggcg gcctccttgc     3960

ctcccttcca cccgtgctgc catcccgtgc ctgtcgtgtt ggttcttcac acgtgctctg     4020

ttctcggggt tgttccattc atgccttctt ggagggtgag ggtggcttgg gaaccgaccc     4080

agtgatcatg cctactttct tctttgtatc tccctccttc ccagcccacc cgggcagcag     4140

actctgatgg aaggaaggtg ccgtaggtgg gcttttagaa actaacggga ctggttttca     4200

aagcagttat cttgggaaac tgtttattcc agcgatgtga cttttttcag aatatttctt     4260

ggaatcatat tcagagtctg gggctgtgtg ttgagcagcc ttaaggatgc tagacactca     4320

tttagtgccc agggagtcca gcgaatgacg tctgtggcca agcgaggtct caggtgcaaa     4380

gcaaaaggac catttaaagt aaaatagctt ggattcaatc atgtgacttt taaattggct     4440

cagaaagcaa ttttgtaatt tcagagagtg ttttgagcca tggccacgtt gtcattgtga     4500

gtctatagct tgactccttg gagaacaata ttcatttggt tgtggagact gatttgctgg     4560

gagaaatctg tcctgttact ttctggtcat cccaggttct gacttttacc aggggcaaaa     4620

aaaaaaaaag caagagggag ataaatccca tctgtgagtt tgtcttattg gcgccttttt     4680

cctcagctgt cttccaagta ttatttttac tgttaaaaaa ttttttaaaa atgtgaaatg     4740

taatgttttt acagcaacaa tatgaaatat attttataag gaataaaatg gtaccttgtc     4800

tgatttaa                                                              4808


<210> 1256
<211> 1485
<212> DNA
<213> Homo sapiens

<400> 1256
gagcccgagc ctagtgcctc ccacgcccgg cggccgcgag ccggggtccg cgagggcgga       60

gtggggcgcg gcagccagga acccgactac gaatcccagg gtgcgggcgg gcggagcgag      120

gagggacgct gggcctgccc ggtgcgcacg ggggcgggga ccggcaaggc gggaccattt      180

cccggcatag gctccggtgc ccctgcccgg ctcccgccgg gaagttctag gccgccgcac      240

agaaagccct gccctccacg ccgggtctct ggagcgccct gggttgcccg gccggtccct      300

gccgctgact tgttgacact gcgagcactc agtccctccc gcgcgcctcc tccccgcccg      360

ccccgccgct cctcctccct gtaacatgcc atagtgcgcc tgcgaccaca cggccggggc      420

gctagcgttc gccttcagcc accatgggga atgggatgaa caagatcctg cccggcctgt      480

acatcggcaa cttcaaagat gccagagacg cggaacaatt gagcaagaac aaggtgacac      540

atattctgtc tgtccacgat agtgccaggc ctatgttgga gggagttaaa tacctgtgca      600

tcccagcagc ggattcacca tctcaaaacc tgacaagaca tttcaaagaa agtattaaat      660

tcattcacga gtgccggctc cgcggtgaga gctgccttgt acactgcctg gccggggtct      720

ccaggagcgt gacactggtg atcgcataca tcatgaccgt cactgacttt ggctgggagg      780

atgccctgca caccgtgcgt gctgggagat cctgtgccaa ccccaacgtg ggcttccaga      840

gacagctcca ggagtttgag aagcatgagg tccatcagta tcggcagtgg ctgaaggaag      900

aatatggaga gagccctttg caggatgcag aagaagccaa aaacattctg gccgctccgg      960

gaattctgaa gttctgggcc tttctcagaa gactgtaatg tacctgaagt ttctgaaata     1020

ttgcaaaccc acagagttta ggctggtgct gccaaaaaga aaagcaacat agagtttaag     1080

tatccagtag tgatttgtaa acttgttttt catttgaagc tgaatatata cgtagtcatg     1140

tttatgttga gaactaagga tattctttag caagagaaaa tattttcccc ttatccccac     1200

tgctgtggag gtttctgtac ctcgcttgga tgcctgtaag gatcccggga gccttgccgc     1260

actgccttgt gggtggcttg gcgctcgtga ttgcttcctg tgaacgcctc ccaaggacga     1320

gcccagtgta gttgtgtggc gtgaactctg cccgtgtgtt ctcaaattcc ccagcttggg     1380

aaatagccct tggtgtgggt tttatctctg gtttgtgttc tccgtggtgg aattgaccga     1440

aagctctatg ttttcgttaa taaagggcaa cttagccaag tttaa                     1485


<210> 1257
<211> 2189
<212> DNA
<213> Homo sapiens

<400> 1257
cggggtcggt aaggggtgcg gcaatgctgc aactgcggga ctcggtggac tcggccggta       60

cgagccccac ggcggtgctg gcggccggcg aggaggtggg ggcaggcggc ggcccgggcg      120

gggggcggcc gggggcgggg acgccgctgc gccagacact ctggcctctc agcatccacg      180

accccacgcg ccgcgcccgc gtcaaggagt acttcgtgtt ccggcccggc agcatcgagc      240

aggcagtgga ggagatccgc gtggtggtgc ggcccgtgga ggacggcgag atccagggag      300

tgtggctgct taccgagcga gaaggttttg ggattcgaat tcagtgggac aagcaaagtc      360

gtccttcctt cataaacaga tggaatccct ggtctaccaa cgtgccctat gccactttca      420

cagaacaccc gatggctggc gcagatgaga agacagcatc tctgtgtcag ttggaaagct      480

tcaaggctct gttaatccaa gctgtcaaaa aagcccaaaa agaaagccct ttgccaggac      540

aggcgaatgg cgtgctgatc ctggagcgcc ccctgctcat cgagacctac gtgggactca      600

tgtccttcat taacaacgag gcgaaactgg gctactccat gaccaggggc aaaataggct      660

tttagccgct gcgttctggg agctcctccc ccttctggga gctcctcccc ctccccagaa      720

ggccaaggga tgtgggggct gggggactgg gaggcctggc agtcttcatg ctgccctgct      780

gctgctggaa ggatggggat ctttcacctt tagggatctc agcacaatta gaatcgtaaa      840

gtgaattcta tctatttaat tggatattgg actctgctca tataagctac agacaaaagc      900

caaaagactc tcgctgtccc tgtgctgctg gtatttcatt ctctgtaact tcagttctgg      960

tgttttcctt gagtatctac ttggcttctc gtggtttttc ccaccccagc tgccccagca     1020

cgcgggaccc atagcacacc ccttagcgct tgcctaggtt gctgaaaaca gggaggcacc     1080

tggtatctcg agtgcctgca gttgcaagta tgtttacacc tggtgtccaa ttttgtattt     1140

taaaatgtaa tccattttta cttcagctca tccaaaagca gccagcagac cggttgactg     1200

agaccggtct gtggctgtgg gccccttggt gacccgctgc tcttttggaa atgggtgacc     1260

tgaagtgaca ctttttccac aattaaccca agttgtgtta atacttcagg tctgtttccc     1320

agacccagaa agctttacag aaaatcattg taagacaatt tattaatttg agaaagtcac     1380

cttgacagtt ctttgcacac aagttttaca cctctctgga ttcgaagttt gtattgtatt     1440

catagttaaa gggaatcggg tactttgctt gttgaataat gcactttaaa acaaggaacc     1500

gtatcaggcc agcatggtgg ctcatgcctg taatcccagc attttgggag gctcaggcag     1560

acaaatcgct ctagctcaga agttgcagag cagcctgggc aacatggtga aacccgtctc     1620

taccaaacag acaaaaagca gccaggcgtg gtggcacatc tgtggtccca gctacttgag     1680

aggctgagcc aggaggatcg cttgagccca ggaggcggag gttgcagtga gctgagatgg     1740

caccacttat tgcactccag cccgggcgac agagcgagac tccatctacc agatccttat     1800

gacgcagctg atgcctgcct tggttcctac cactctggtg tagacagagg actttgtcca     1860

agtctcacac taaacatgcc cgggcttcga tgtgcctgga ggatttcccc acagggaccc     1920

acgcacctcc ctgtatctgc gcagcttgct cgtgtggctg gaagcgctgt cgataagctt     1980

cacgcactgg cttgccagtt cttcagctct aggacttgta gctttaagca aacggtgtgg     2040

catgggttga gtgtggccac ctgcaggatg tgcagggctg cctcagaagc tggctgggga     2100

ctctagcctc tgtgttcata aagacattaa gaagtggatg gatgttgttc cttttttgaa     2160

gttgtcatta aagtaggtgc aacaaccaa                                       2189


<210> 1258
<211> 1592
<212> DNA
<213> Homo sapiens

<400> 1258
gtccctttga tgacgcggag cctgagccag accaggggga tccaggggcc tgctgctccc       60

tgtgcgccca gaccatccag gatgaagagg ggcccttgtg ttgcccccac cctggctgcc      120

tgctaagggc ccatgtgatc tgcctggcag aggagtttct tcaggaagaa ccagggcagc      180

ttctgcccct agagggccaa tgcccttgct gtgagaagtc actgctttgg ggagacctga      240

tctggctgtg ccagatggac actgagaaag aagtagaaga ctcagaatta gaagaggaac      300

atggagctga tccaggacac ctcccgcccg ccactggagt acgtgaaggg ggtcccgctc      360

atcaagtact ttgcagaggc actggggccc ctgcagagct tccaagcccg acctgatgac      420

ctgctcatca acacctaccc caagtctggc accacctggg tgagccagat actggacatg      480

atctaccagg gcggcgacct agagaagtgt aaccgggctc ccatctacgt acgggtgccc      540

ttccttgagg tcaatgatcc aggggaaccc tcagggctgg agactctgaa agacacaccg      600

cccccacggc tcatcaagtc acacctgccc ctggctctgc tccctcagac tctgttggat      660

cagaaggtca aggtggtcta tgttgcccga aacccaaagg acgtggcggt ctcctactac      720

catttccacc gtatggaaaa ggcgcaccct gagcctggga cctgggacag cttcctggaa      780

aagttcatgg ctggagaagt gtcctacggg tcctggtacc agcacgtgca ggagtggtgg      840

gagctgagcc gcacccaccc tgttctctac ctcttctatg aagacatgaa ggagaacccc      900

aaaagggaga ttcaaaagat cctggagttt gtggggcgct ccctgccaga ggagaccatg      960

gacttcatgg ttcagcacac gtcgttcaag gagatgaaga agaaccctat gaccaactac     1020

accaccgtcc cccaggagct catggaccac agcatctccc ccttcatgag gaaaggcatg     1080

gctggggact ggaagaccac cttcaccgtg gcgcagaatg agcgcttcga tgcggactat     1140

gcggagaaga tggcaggctg cagcctcagc ttccgctctg agctgtgaga ggggctcctg     1200

gagtcactgc agagggagtg tgcgaatcta ccctgaccaa tgggctcaag aataaagtat     1260

gatttttgag tcaggcacag tggctcatgt ctgcaatccc agcgatttgg gaggttgagc     1320

tggtaggatc acaataggcc acgaatttga gaccagcctg gtaaaatagt gagacctcat     1380

ctctacaaag atgtaaaaaa attagccaca tgtgctggca cttacctgta gtcccagcta     1440

cttgggaagc agaggctgga ggatcatttc agcccaggag gttgtggata cagtgagtta     1500

tgacatgccc attcactaca gcctggatga caagcaagac cctccctcca aagaaaataa     1560

agctcaaaat aaaatatgat ttgtgttcat gt                                   1592


<210> 1259
<211> 5356
<212> DNA
<213> Homo sapiens

<400> 1259
ccttaattag aaatgcgtta gcgaatatta tacgcttata ctatgggcgg acgggtggag       60

agccttaaaa acaacaacaa caaactaagc agttgctcaa tcgttgattg atcctcaggc      120

acgtctagat tttcccactt acataggtct tgttaagaaa ccagtcctgc cttcttgcca      180

ctcgtgtctt tcgatggctc ccttcccgaa gtcccgctgc ctctaagcgg agtgttaagc      240

ggggctctcg gaagccggtg gaccgagatt tccccgggtg gggcgggcgc ggtgtagcgg      300

cccgcgggct gacttgctcc cggctgtccc ccggccccag cgaccatgcc ccgtaaaggc      360

acccagccct ccactgcccg gcgcagagag gaagggccgc cgccgccgtc ccctgacggc      420

gccagcagcg acgcggagcc tgagccgccg tccggccgca cggagagccc agccaccgcc      480

gcagagactg caagtgagga acttgataat agaagtttag aagagatttt gaacagcatt      540

cctcctcccc cgcctccagc aatgaccaat gaagctggag ctcctcggct tatgataact      600

catattgtaa accagaactt caaatcctat gctggggaga aaattctggg acctttccat      660

aagcgctttt cctgtattat cgggccaaat ggcagtggca aatccaatgt tattgattct      720

atgctttttg tgtttggcta tcgagcacaa aaaataagat ctaaaaaact ctcagtatta      780

atacataatt ctgatgaaca caaggacatt cagagttgta cagtagaagt tcattttcaa      840

aagataattg ataaggaagg ggatgattat gaagtcattc ctaacagtaa tttctatgta      900

tccagaacgg cctgcagaga taatacttct gtctatcaca taagtggaaa gaaaaagaca      960

tttaaggatg ttggaaatct tcttcgaagc catggaattg acttggacca taatagattt     1020

ttaattttac agggtgaagt tgaacaaatt gctatgatga aaccaaaagg ccagactgaa     1080

cacgatgagg gtatgcttga atatttagaa gatataattg gttgtggacg gctaaatgaa     1140

cctattaaag tcttgtgtcg gagagttgaa atattaaatg aacacagagg agagaagtta     1200

aacagggtaa agatggtgga aaaggaaaag gatgccttag aaggagagaa aaacatagct     1260

atcgaatttc ttaccttgga aaatgaaata tttagaaaaa agaatcatgt ttgtcaatat     1320

tatatttatg agttgcagaa acgaattgct gaaatggaaa ctcaaaagga aaaaattcat     1380

gaagatacca aagaaattaa tgagaagagc aatatactat caaatgaaat gaaagctaag     1440

aataaagatg taaaagatac agaaaagaaa ctgaataaaa ttacaaaatt tattgaggag     1500

aataaagaaa aatttacaca gctagatttg gaagatgttc aagttagaga aaagttaaaa     1560

catgccacga gtaaagccaa aaaactggag aaacaacttc aaaaagataa agaaaaggtt     1620

gaagaattta aaagtatacc tgccaagagt aacaatatca ttaatgaaac aacaaccaga     1680

aacaatgccc tcgagaagga aaaagagaaa gaagaaaaaa aattaaagga agttatggat     1740

agccttaaac aggaaacaca agggcttcag aaagaaaaag aaagtcgaga gaaagaactt     1800

atgggtttca gcaaatcggt aaatgaagca cgttcaaaga tggatgtagc ccagtcagaa     1860

cttgatatct atctcagtcg tcataatact gcagtgtctc aattaactaa ggctaaggaa     1920

gctctaattg cagcttctga gactctcaaa gaaaggaaag ctgcaatcag agatatagaa     1980

ggaaaactcc ctcaaactga acaagaatta aaggagaaag aaaaagaact tcaaaaactt     2040

acacaagaag aaacaaactt taaaagtttg gttcatgatc tctttcaaaa agttgaagaa     2100

gcaaagagct cattagcaat gaatcgaagt agggggaaag tccttgatgc aataattcaa     2160

gaaaaaaaat ctggcaggat tccaggaata tatggaagat tgggggactt aggagccatt     2220

gatgaaaaat acgacgtggc tatatcatcc tgttgtcatg cactggacta cattgttgtt     2280

gattctattg atatagccca agaatgtgta aacttcctta aaagacaaaa tattggagtt     2340

gcaaccttta taggtttaga taagatggct gtatgggcga aaaagatgac cgaaattcaa     2400

actcctgaaa atactcctcg tttatttgat ttagtaaaag taaaagatga gaaaattcgc     2460

caagcttttt attttgcttt acgagatacc ttagtagctg acaacttgga tcaagccaca     2520

agagtagcat atcaaaaaga tagaagatgg agagtggtaa ctttacaggg acaaatcata     2580

gaacagtcag gtacaatgac tggtggtgga agcaaagtaa tgaaaggaag aatgggttcc     2640

tcacttgtta ttgaaatctc tgaagaagag gtaaacaaaa tggaatcaca gttgcaaaac     2700

gactctaaaa aagcaatgca aatccaagaa cagaaagtac aacttgaaga aagagtagtt     2760

aagttacggc atagtgaacg agaaatgagg aacacactag aaaaatttac tgcaagcatc     2820

cagcgtttaa tagagcaaga agaatatttg aatgtccaag ttaaggaact tgaagctaat     2880

gtacttgcta cagcccctga caaaaaaaag cagaaattgc tagaagaaaa cgttagtgct     2940

ttcaaaacag aatatgatgc tgtggctgag aaagctggta aagtagaagc tgaggttaaa     3000

cgcttacaca ataccatcgt agaaatcaat aatcataaac tcaaggccca acaagacaaa     3060

cttgataaaa taaataagca attagatgaa tgtgcttctg ctattactaa agcccaagta     3120

gcaatcaaga ctgctgacag aaaccttcaa aaggcacaag actctgtctt gcgtacagag     3180

aaagaaataa aagatactga gaaagaggtg gatgacctaa cagcagagct gaaaagtctt     3240

gaggacaaag cagcagaggt cgtaaagaat acaaatgctg cagaggaatc cttaccagag     3300

atccagaaag aacatcgcaa tctgcttcaa gaattaaaag ttattcaaga aaatgaacat     3360

gctcttcaaa aagatgcact tagtattaag ttgaaacttg aacaaataga tggtcacatt     3420

gctgaacata attctaaaat aaaatattgg cacaaagaga tttcaaaaat atcactgcat     3480

cctatagaag ataatcctat tgaagagatt tcggttctaa gcccagagga tcttgaagcg     3540

atcaagaatc cagattctat aacaaatcaa attgcacttt tggaagcccg gtgtcatgaa     3600

atgaaaccaa acctcggtgc catcgcagag tataaaaaga aggaagaatt gtatttgcaa     3660

cgggtagcag aattggacaa aattacttat gaaagagaca gttttagaca ggcatatgaa     3720

gatcttcgga aacaaaggct taatgaattt atggcaggtt tttatataat aacaaataaa     3780

ttaaaggaaa attaccaaat gcttactttg ggaggggacg ccgaactcga gcttgtagac     3840

agcttggatc ctttctctga aggaatcatg ttcagtgttc gaccacctaa gaaaagttgg     3900

aaaaagatct tcaacctttc gggaggagag aaaacactta gttcattggc tttagtattt     3960

gctcttcacc actacaagcc cactcccctt tacttcatgg atgagattga tgcagccctt     4020

gattttaaaa atgtgtccat tgttgcattt tatatatatg aacaaacaaa aaatgcacag     4080

ttcataataa tttctcttcg aaataatatg tttgagattt cggatagact tattggaatt     4140

tacaagacat acaacataac aaaaagtgtt gctgtaaatc caaaagaaat tgcatctaag     4200

ggactttgtt gaactttatg ctgaagattc ttcaagttga ttcagtgtat tactgatttt     4260

tttctatttg taaaggatta tgagttgtat aaaatacata ctccctaaac tagatcatga     4320

aactggtttc tgttttatgc agttgtcatt tgtaaagtct aataaaatat tctctataat     4380

tgcttctaga ttacaaaaat atgacaatct tgtaagtagc agactatgga gaaaaatgag     4440

ttacctggag ggtcaggtaa cttgccaaac taaaaagtat gttagttgag gcaaagtcct     4500

aagcaaggtt gtgctatcaa ggctcagcat accttcgtgg gcctttgatt taccaacact     4560

ggaaatgcct gccaactaat cttggataga ttctttaagg cattccactt agcttgccag     4620

ttgagacaat caccacagtt attacccaaa tactatgaac atatttttgt aaaccagtca     4680

ttctgaatta tagtgatgag aatttaaata tatgcttttc tagaatttga tgtttgacca     4740

tttatgactt aattaccaga gagccagtaa attaggacag tgtttcaaca agcctaggct     4800

atctcgtaag ttgaaaaata tcccactata gttgcttcat gagtatgaag taagatggcc     4860

tctgatttac actggttcaa tttacaaatt ttcaacttta tgataggttt atccgggtac     4920

taaatgcatt tcaacttgat agtttcaact tatgataggt ttaccaggat gtagtcccac     4980

tgttgaggag catctattta ggggttaatt actttagtaa taagtggaaa gtaagatacc     5040

ttgagtaatg tttgcctata aaattgtcag cgtattttta cactattggc tcaagaatgt     5100

tataatgcta agggacataa gttggcaacc acttggtttt tggaaggact ttcggtattg     5160

tattagaagt ctgccctagc tgttaaattt ctgggtattt atcctaagga attaattaaa     5220

gagttaattg ttcctttctt cagtgggcca ttgttttaga tatttaaaaa atccaacagt     5280

ttctatcata atgtaactgt aaaaatgtaa acacattatt agcatggact tttaaataaa     5340

gatttaaaga aagcaa                                                     5356


<210> 1260
<211> 3893
<212> DNA
<213> Homo sapiens

<400> 1260
ataaggctac ggatgggcgg gacggagcag cccaccgcaa agtggcggtc tacttgaggc       60

ggttacctta gtactccgag tagactgagt ctgtggcgag ctgcgggccg attcctggcc      120

agtgccatct cagccggagc aggcctcggg gcctcagaag caggctttta tctggcccga      180

ggctcccagc cgttcagcgc gtcttcccat aacctatacc gattattggg actctcggct      240

gcagacacag gagtcacaga tgctgggaag tatggcccga aagaaacctc gaaatacctc      300

aaggttgccc ctggctttaa accccctgaa gagcaaggac gtgttggcag tgctggctga      360

gaggaacgag gctatagtac cagttggggc atgggtggaa cctgcctcac caggtagttc      420

ggaaatccca gcatatacat cagcatattt aattgaagaa gaactaaagg aacagctaag      480

aaaaaaacaa gaagctttga aacattttca gaaacaagtt aaataccgag taaatcaaca      540

aattaggttg agaaaaaagc aacagcttca gaagtcttat gaaagagcac aaaaagaagg      600

ctccatagcc atgcagtctt cagcaacaca cttaacttcc aaaaggacaa gtgtttttcc      660

aaacaatttg aatgttgcta ttggaagttc taggttacct ccttccctga tgcctgggga      720

tggaatagag gatgaagaga atcagaacga attattccaa caacaagccc aggctcttag      780

tgaaactatg aaacaggcac gtcaccggct agcatccttt aaaaccgtga ttaaaaaaaa      840

gggatcagtg tttccagatg atggaaggaa aagctttctt accagagagg aagtgctttc      900

caggaaacca gcatccactg ggataaatac aggaataaga ggagagttgc ccattaaggt      960

ccatcaaggt cttttagctg ctgtacctta ccagaattat atggaaaatc aggaacttga     1020

ctatgaggaa cctgactatg aggaatcttc atctcttgta actgatgaga aagggaaaga     1080

agatttgttt gggagaggcc agcaggacca gcaggctatc cattctgaag ataagaacaa     1140

acctttcagc agagttcaga aagtaaaatt caaaaatcca ttatttgttc tgatggaaga     1200

ggaagaacaa aagcagttac attttgaggg ccttcaggat attctgccag aagcccagga     1260

ttattttcta gaagcccaag gtgatttgct ggaaacccag ggtgatttga caggaatcca     1320

gagtgttaag ccagataccc aggctgttga aatgaaggtt caggttactg agccagaagg     1380

ccaggccatt gagccagaag gccagcctat taagacagaa actcagggta ttatgctgaa     1440

agcccagagt attgagctag aagaagggag tattgtgttg aaaacccagg attttctacc     1500

cacaaatcag gctcttctaa cgaaaaacca ggatgtttta ctcaaagacc actgtgttct     1560

ccctaaagac cagagtattc tactcaaata tcaggaccag gacttcctac ccagagacca     1620

gcatgttctc cacaaagacc aagatattct gccaaaatat caggaccaga attttctacc     1680

taaggaccag aattttttat ctagagacca gcatgttctc cccaaagacc aagatattct     1740

gccaaaatat caggaccaga attttctacc taaggaccag aattttttgt ctagagacca     1800

gcatgttctc cccaaagacc agaatattct acctaaatat caaggccagg attttctacc     1860

taaagaccag gactttttat ctagagacca gcatgttctc cccaaagact ggaatattct     1920

acccaaatgt caggaccagg attttctacc cagagaccaa ggtgttcttc ccaaagacca     1980

aaatattcta cccatatgtc aggaccagga ttttctaccc agagaccaag gttatcttcc     2040

taaagaccaa aatattctac ccatatgtca ggaccgggat tttctaccca gagacctgca     2100

tgttctctcc aacgaccaga atattctacc caaatgtcag gaccaagatt ttctaccaaa     2160

atatcagaaa gtacacttta aggagccata ctctgatatg acagatgaga aagggagaga     2220

agacttttct ctggcagact atcagtgttt gcctcccaaa tcccaggacc aggatgacat     2280

caaaaatcag caacctgcat cttttatgag agaagaaaga gtgagagaag aattgcctct     2340

ggactatcat caatatgttg tacctaaaat ccaggaccaa gactccccta gagaacagaa     2400

caagcatatc aaactaccct catcttttga gaaatgggag attgcaagag gaaatactcc     2460

tggagtgccc ttggcttatg ataggtatca atcaggattg agcactgaat tccaagctcc     2520

actggcattt cagtctgacg tggataaaga agaagataag aaagagcgtc aaaagcagta     2580

cctgagacat agacgacttt tcatggatat tgagagagaa caagttaaag aacaacaaag     2640

gcaaaaagaa caaaagaaga aaattgaaaa aattaagaaa aagagagagc aagaatgtta     2700

tgctgcagag cagaggatcc taagaatgaa ctttcatgaa gatccatatt caggagagaa     2760

gttgagtgag atattagccc agttacaact tcaagaaata aaaggaacca gagaaaaaca     2820

acagagagaa aaagaatacc tgagatatgt agaagcttta cgagcccaaa tccaggagaa     2880

aatgcagctg tataatatta ctttacctcc actatgctgt tgtggtcctg atttttggga     2940

tgctcatcct gatacctgtg ccaacaactg tattttctat aaaaaccaca gagcatatac     3000

tcgggcacta cattcattca tcaattcctg tgatgtccct gggggtaatt caactcttcg     3060

agtcgcaatt cataattttg cttctgcaca caggcggact ttgaaaaatc tataataaga     3120

atctgaaatt aactggtagt attttggctt ttacttaaaa tcatccctga gagagtattt     3180

aagaaaagct gttcaagtta taaaatatat aatctgggaa gaaatactgt ctcatataat     3240

aattagattg taatcattgt tttaatctct gtctgggaac caagattgaa agctgactta     3300

cttctctctt ctgtcttgtg aaccatacgg agcctattat tttaaaatat gatcagacaa     3360

gtaaggcttc tcttactttg ctctgctctg atcagaagag ctcatgtgaa gtctttgaga     3420

ttctcttatt tatcatcttt ctaaaactgt gtttttgagc ttgacagtac tgaaaatgtc     3480

tggatgaagc agaaaagaaa gtgatgaaat gtgtttctga gcatcagaga ccatctatat     3540

tgccattacc ttttctagtt gtatataaga attcaagatt agaagaattt agatttgttg     3600

cacatttttt tcctcagcat tttttcctct tgttttttaa aatgtattgc ctctttcccc     3660

attcagtgac actggacata ggaattttta attgtgtaat tttctgttgc aaaaagggta     3720

aataaatcct ttgtcttttg aatatcttct atgtgaaata attgtgagtg acatttgaaa     3780

aagtgaatct gaagtcaaag tgagtaaatt ccttatttcc ctatttttta aaaacctggt     3840

atatgacatg gctacagggc aaatgaaata aaaattgcca tagttggtat gaa            3893


<210> 1261
<211> 1852
<212> DNA
<213> Homo sapiens

<400> 1261
gagtgcgcac gcatcctgcc cgcggcgcgc gcgcaggtcg gtgcgtctgt cgggggcgcg       60

ctcgggtacc tgtaccccac gtagtcgccg gttaccgatc ggactaagtt ccagtggtga      120

tttacaagtc aagttaaaat gtccccagaa gtggccttga accgaatatc tccaatgctc      180

tcccctttca tatctagcgt ggtccggaat ggaaaagtgg gactggatgc tacaaactgt      240

ttgaggataa ctgacttaaa atctggctgc acatcattga ctcctgggcc caactgtgac      300

cgatttaaac tgcacatacc atatgctgga gagacattaa agtgggatat cattttcaat      360

gcccaatacc cagaactgcc tcccgatttt atctttggag aagatgctga attcctgcca      420

gacccctcag ctttgcagaa tcttgcctcc tggaatcctt caaatcctga atgtctctta      480

cttgtggtga aggaacttgt gcaacaatat caccaattcc aatgtagccg cctccgggag      540

agctcccgcc tcatgtttga ataccagaca ttactggagg agccacagta tggagagaac      600

atggaaattt atgctgggaa aaaaaacaac tggactggtg aattttcagc tcgtttcctt      660

ttgaagctgc ccgtagattt cagcaatatc cccacatacc ttctcaagga tgtaaatgaa      720

gaccctggag aagatgtggc cctcctctct gttagttttg aggacactga agccacccag      780

gtgtacccca agctgtactt gtcacctcga attgagcatg cacttggagg ctcctcagct      840

cttcatatcc cagcttttcc aggaggagga tgtctcattg attacgttcc tcaagtatgc      900

cacctgctca ccaacaaggt gcagtacgtg attcaagggt atcacaaaag aagagagtat      960

attgctgctt ttctcagtca ctttggcaca ggtgtcgtgg aatatgatgc agaaggcttt     1020

acaaaactca ctctgctgct gatgtggaaa gatttttgtt ttcttgtaca cattgacctg     1080

cctctgtttt tccctcgaga ccagccaact ctcacatttc agtccgttta tcactttacc     1140

aacagtggac agctttactc ccaggcccaa aaaaattatc cgtacagccc cagatgggat     1200

ggaaatgaaa tggccaaaag agcaaaggga tgccaaggga gcagagatgc ctgcagcccg     1260

tgggagcaag tcctggcctt tgcagttgca aaaactggct gcaagctgct ccagccccag     1320

aggaactggc caagctccag agggcctcct tggagggcct cagagggaga gagaactgct     1380

cagtaatttt gatcactttg ggcttatttc aaaacctttg tccctcagtt ccaggaggca     1440

gcatttgcca atggaaagct ctaggaaaca ccagtcttga gaggtggcca gccagactgc     1500

ctgtccacat gcgtgtcagc acatacagcc gcttcctgga agccgcctgg aatgtcttca     1560

cggcagcgtt ttgctcacac agcagctttt gcacgcccca ggcagccccg actgctgaaa     1620

tccaacttga gctggctggt ggtccctgga tcctagagcc cttcacttcg ggttactccc     1680

tctttcttgc ctctatttct tagttggaag aaataaactc acaaattatg gtgcagtaat     1740

tttccgggga aagtaaagcc tcaggaatgc ccacgccttt cttccaaagc ctttgtctct     1800

gagacctctt aagttctaag attaaatgcc cctcgctgtt cttcctctga aa             1852


<210> 1262
<211> 1678
<212> DNA
<213> Homo sapiens

<400> 1262
ctctggttcc cttccacgct gtggaagctt tgttcttttg gtcttcatga taaatcttgc       60

tgctgctcac tcgttgggtc cgtgccacct ttaagagctg taacactcac cgcgaaggtc      120

tgcaacttca ctcctggggc cagcaagacc acgaatgcac cgagaggaat gaacaactct      180

ggacacacca tctttaagaa ccgtaatact caccgcaagg gtctgcaact tcattcttga      240

agtcagtgag gccaagaacc catcaattcc gtacacattt tggtgacttt gaagagactg      300

tcacctatca ccaagtggtg agactattgc caagcagtga gactattgcc aagtggtgag      360

accatcacca agcggtgaga ctatcaccta tcgccaagtg gcctgattca gcaggaagca      420

tctcagacac caaccactat gctgtcagca gttgcccggg gctaccaggg ctggtttcat      480

ccctgtgcta ggctttctgt gaggatgagc agcaccggga tagacaggaa gggcgtcctg      540

gctaaccggg tagccgtggt cacggggtcc accagtggga tcggctttgc catcgcccga      600

cgtctggccc gggacggggc ccacgtggtc atcagcagcc ggaagcagca gaacgtggac      660

cgggccatgg ccaagctgca gggggagggg ctgagtgtgg cgggcattgt gtgccacgtg      720

gggaaggctg aggaccggga gcagctggtg gccaaggccc tggagcactg tgggggcgtc      780

gacttcctgg tgtgcagcgc aggggtcaac cctctggtag ggagcactct ggggaccagt      840

gagcagatct gggacaagat cctaagtgtg aacgtgaagt ccccagccct gctgctgagc      900

cagttgctgc cctacatgga gaacaggagg ggtgctgtca tcctggtctc ttccattgca      960

gcttataatc cagtagtggc gctgggtgtc tacaatgtca gcaagacagc gctgctgggt     1020

ctcactagaa cactggcatt ggagctggcc cccaaggaca tccgggtaaa ctgcgtggtt     1080

ccaggaatta tcaaaactga cttcagcaaa gtggtgagga ttggtttcat gggaatgagt     1140

ctctctggaa gaacttcaag gaacatcatc agctgcagag gattggggag tcagaggact     1200

gtgcaggaat cgtgtccttc ctgtgctctc cagatgccag ctacgtcaac ggggagaaca     1260

ttgcggtggc aggctactcc actcggctct gagaggagtg ggggcggctg cgtagctgtg     1320

gtcccaggcc caggagcctg agggggtgtc taggtgatca tttggatctg gaggcagagt     1380

ctgccattct gccagactag caatttgggg gcttactcat gctaggcttg aggaagaaga     1440

aaaacgcttc ggcattctcc ttaggactta tctgcttgta gatttggctg atccaattaa     1500

catgtggggt tcttggtgtg ggtctgggga gctgaaggat tttatggagc tggtgctttg     1560

gaggaatctt aagggaaagg agtagaagct caggcctttg aaggatttca gctcctcctc     1620

tctgtaattt gtgctttaag catttttttt cctaaaataa actcaaattt atcctcaa       1678


<210> 1263
<211> 1187
<212> DNA
<213> Homo sapiens

<400> 1263
atgaggtttg atactttatg ggaaaacaaa ctaatgcagt ccagggcagt agatggattt       60

cattcagaag agcagcagct tctactgcaa gttcaacagc agcatcaacc ccagcagcag      120

cagcatcacc accatcacca tcatcagcaa gctcagcctc agcagacagt acctcagcaa      180

gcgcagaccc agcaggttct tattcctgca tcacagcaag ccacagcacc acaagttatt      240

gttccagatt ctaagttgat acagcatatg aatgcatcaa acatgagtgc tgctgctaca      300

gctgctacct tagcactccc tgcaggtgtg actcctgttc agcagatatt aacaaattca      360

ggccagcttc ttcaggtggt cagagcagcc aatggtgccc aatatatctt tcagcctcag      420

cagtcagtgg ttctacaaca acaggttata ccacaaatgc agcctggtgg agtacaagct      480

cctgttatac agcaggtgct ggctcctctt cctggaggga tttcaccaca gacaggtgtc      540

atcatccagc ctcagcaaat cttatttaca ggaaataaga ctcaagttat acctacgaca      600

gtggcagcac ctacaccagc ccaagcacag ataactgcaa ctggccagca gcaaccgcag      660

gcccagcctg ctcaaacaca agctccattg gtcttacaag ttgatggaac tggggataca      720

tcatctgaag aagatgaaga tgaagaagaa gactatgatg atgatgagga ggaagacaaa      780

gagaaagatg gagctgaaga tgggcaggtg gaagaagagc ccctcaatag tgaagatgat      840

gtgagtgatg aggaaggaca ggaactcttt gacacagaaa atgttgttgt atgccaatat      900

gataagatac acagaagtaa aaacaaatgg aaatttcatc tcaaggatgg cattatgaat      960

cttaatggaa gagattatat attttccaaa gccattggag atgcagaatg gtgaagagtt     1020

gctttttttc ttttataaat aaaagaaact taaaaaaaat gtaaagcgga cagtttgaaa     1080

cttggggcat atgccaacca aaacttcgtt tctgcatgtc agaaaagtgc agtagaagca     1140

aagctactgg aacaaagata gaccttgaca acatagacac tacttac                   1187


<210> 1264
<211> 561
<212> DNA
<213> Homo sapiens

<400> 1264
gcagtcgctg ccgaccggct ggctgggcct tgcggcgtga ggaccccggc ggcgccgcag       60

tcccgcgagc catggcccag tccggcgggg aggctcggcc cgggcccaag acggcggtgc      120

agatccgcgt cgccatccag gaggccgagg acgtggacga gttggaggac gaggaggagg      180

gggcggagac tcggggcgcc ggggacccgg cccggtacct cagccccggc tggggcagcg      240

cgagcgagga ggagccgagc cgcgggcaca ggaataggag ctcggtgaat tcaaggacca      300

tgcttgcttc gttcattgta tcttcagcac ctagcacagc acccagcaca taggacatgt      360

ttgttgactg aatgcgtatc tctatcatca cactcactca atggtgttga gatatttgtg      420

tttccccttc cctagacagt gagatccttg aaggcagctg ccttatctta ttcctttttg      480

tatttccata cctagcctaa tacctagctt atataaggga acagaataaa tgaacaataa      540

agaaaagtct ttacagcctc t                                                561


<210> 1265
<211> 892
<212> DNA
<213> Homo sapiens

<400> 1265
gtgcgcactg gcgtgcgaga ctcggcgggc gctgttgagg gagtcgggcc gcgactgtgg       60

tcgtttttat accttcccgc gcggacgccg gcgctgccaa cggaagggcg ggtagggcgg      120

tgcgtgatta ggttggcgaa gagacggagt ttcgtcatgt tggccaggcc catttgagat      180

ctttgaagat atcctcaacg tgaggctctg ctgccatgaa ggtgaagatt aagtgctgga      240

acggcgtggc cacttggctc tgggtggcca acgatgagaa ctgtggcatc tgcaggatgg      300

catttaacgg atgctgccct gactgcaagg tgcccggcga cgactgcccg ctggtgtggg      360

gccagtgctc ccactgcttc cacatgcatt gcatcctcaa gtggctgcac gcacagcagg      420

tgcagcagca ctgccccatg tgccgccagg aatggaagtt caaggagtga ggcccgacct      480

ggctctcgct ggaggggcat cctgagactc cttcctcatg ctggcgccga tggctgctgg      540

ggacagcgcc cctgagctgc aacaaggtgg aaacaagggc tggagctgcg tttgttttgc      600

catcactatg ttgacacttt tatccaataa gtgaaaactc attaaactac tcaaatcttg      660

ctggaggcct ctgggtgcct gtgttctcgg catatagatg tggtctcggt gtgttttgat      720

atgaaaactc tcatgaataa acatctccgt gaaacgccaa ggccctcgtc aaaccctgag      780

tcatgactgg gaggagaagg agcaggatca gacggtagag cctggggcat gctcttcagg      840

catgctcttg cctgctggat tgccggcggc ggccctggga ccctccctca gg              892


<210> 1266
<211> 1038
<212> DNA
<213> Homo sapiens

<400> 1266
taagtgtaca tgcttaggcc ttctgaagca gcatttgaag ctgcagtcct gaaaaccatg       60

caggccggaa gagtagataa agaaatattt atttgagatg gcacatgttt cttcagaaac      120

tcaagatgtt tcccccaaag atgaattaac tgcttcagaa gcctccacta ggtctccatt      180

gtgtgaacac accttccctg gggactcaga cttacggtca atgattgaag aacatgcttt      240

tcaggttttg tcacaaggat ccttgttaga aagtccaagt tacacagttt gtgtctctga      300

gccagataaa gatgatgatt ttctttctct gaactttccc aggaaacttt ggaaaatagt      360

ggaaagtgac caattcaagt ctatttcatg ggatgagaat ggaacttgca tagtgattaa      420

tgaagaactc ttcaagaaag aaattttgga aacaaaggct ccttacagaa tatttcaaac      480

tgatgctatc aaaagttttg ttcgacagct caacctttat ggatttagta aaattcaaca      540

gaattttcaa agatctgcct ttctagccac ctttctgtca gaagagaaag aatcgtctgt      600

cttaagcaag atacgcttca ccaaaatgaa actttccaga tcttcaactt atgaaaacag      660

gtatttatgt tgcaacttac atttaaaaga tgagtcgaat tactcataat ccttagaagt      720

tagcttgtcc gcatctgaaa attcactttt accttgaagt tcaatctgtc tctgggaaag      780

actagattgg aagaataaaa ttcaagaatg tgatgtttta gtaatggaaa agccaagagc      840

gtcaggtggc aaaagtcctt ctgttactca agaaaatgct ctgaaaaatt ccttttctct      900

tttttttttg taaagattaa ctccacctca ccaccacaat gaggtatttt tctcagcaat      960

tgacacctgt ttactcagtt actccctgta actatgttat gctgtgaagt aggcaataca     1020

gttgttaaag aagaataa                                                   1038


<210> 1267
<211> 2470
<212> DNA
<213> Homo sapiens

<400> 1267
aaggcggagc ggtccctgca acccggccgg cgggaactgc cttctagttt ttagtctcag       60

accagaccac cgggcgcacc ccgatgccga gcccgcagct tctggtgctc ttcggcagcc      120

agacaggcac ggctcaggat gtgtcggaga gactgggtcg cgaggcccgg cgccggcggc      180

ttggctgccg ggtgcaggcc ctggactcct acccggtggt gaatctgatt aacgagcccc      240

tggtgatatt tgtttgtgca actacaggcc aaggagaccc ccctgacaac atgaagaact      300

tctggaggtt tatattccgg aagaacctgc cctccactgc cctctgtcag atggactttg      360

ccgtcctggg cctcggggac tcctcatacg ccaagttcaa cttcgtggcc aagaagctgc      420

accgacggct actgcagctt gggggcagcg ccctcctgcc cgtgtgcctg ggcgatgacc      480

agcatgagct ggggcccgac gctgctgtgg acccctggct gcgagacttg tgggacaggg      540

ttctggggct gtacccgccg cctccgggcc tcactgagat ccctcccgga gtccccctgc      600

cctccaagtt caccctgctg ttcctccaag aggcacccag cacgggctct gaggggcagc      660

gggtagctca ccccggctct caggagcccc cgtcagagtc gaagcccttc ctagcaccca      720

tgatctccaa ccagagagtc accggcccct cccacttcca ggacgttcgg ctgattgagt      780

ttgacatctt gggctctggc atcagctttg ctgctggtga tgtggtgctg attcagccct      840

ccaactcggc tgcccatgtc cagcggttct gccaggtgct gggcctggac cctgaccagc      900

tcttcatgct gcagccgcgg gagccagatg tctcctcccc cacgaggctg ccccagccct      960

gctccatgcg gcacctcgtg tcccactacc tggacatcgc cagcgtgcct cgccgctcct     1020

tcttcgaact cctggcctgt ctatccctcc atgagctgga gcgggagaag ctgctggagt     1080

tcagttctgc ccaaggccag gaggagctct ttgaatactg caaccggccc cgcaggacca     1140

tcctggaggt gctctgtgac ttcccgcaca cagctgccgc catccctccc gactacctgt     1200

tggacctcat ccccgttatc cggccgaggg ccttctccat cgcctcctcg ctgctgactc     1260

acccctcacg gctgcagatc ctcgtggctg tagtgcagtt ccagactcgc ctcaaggagc     1320

cccgccgggg cctctgctcc tcctggctgg catccctgga ccctgggcaa ggacctgtcc     1380

gggtgcccct ctgggtgcgg cctgggagtc tggccttccc agagacacca gacacacctg     1440

tgatcatggt ggggcctggc actggggtag cccccttccg agcagccatc caggagcgtg     1500

tggcccaggg ccagactgga aacttcttgt tttttggctg ccgctggcgg gaccaagact     1560

tctactggga ggctgagtgg caggagctgg agaagcggga ctgtctgacc ctcatccctg     1620

ccttctcccg ggaacaggag cagaaagtat atgtgcagca ccggctccgg gagctggggt     1680

cgcttgtgtg ggaactgctg gaccgccagg gtgcatactt ctacctggca ggcaacgcca     1740

agtccatgcc agcggacgtc tcggaagccc tgatgtccat cttccaggag gagggtggac     1800

tctgcagccc ggacgcagcc gcgtatctag ccaggctcca gcagacacgg cgcttccaga     1860

cagagacgtg ggcctgaggc ccgcggctgc ccgtgccccc tctgacagcc atcctcctgg     1920

gagcccagga aggcatccac gagggagctc ctggccagca gccgtcatcc tctcggacca     1980

gccagctggt cctctgggaa cagccagctc ccgagcacag ccgcactcct gttgaccctg     2040

gatcccaccc tttgagcctg accccactgc agcctctgcc cagccagccc tgcgctcccc     2100

caccctgaca gtgagctgtg tcctcgtccc cccaccccct tcccagtcaa ggtggtggcc     2160

tgggccgctc cacctcaccg gtgcagtgac ccaggacggc atcagcagcc cagtgagcac     2220

caggggtggc atagggcacc catgaggctg cgctgcactc ctctgccctg gggccacctc     2280

ggctgctgca gcctgcccag cagcacattc cagtcactgc ccccgcactc ccacagggct     2340

caggctgggc tcagaggcca ctgagatgcc agctccttga gagcagtggg ggtgtcccag     2400

gccagagcag cctcttcctc tcctggtccc agaaaaaccc ttgcagtaaa tggtggcctc     2460

tgggtggtta                                                            2470


<210> 1268
<211> 2135
<212> DNA
<213> Homo sapiens

<400> 1268
ttttattaat atgctgatct gttttatctt ctcaggccat aaagaatgct gatgggagaa       60

ccattttcct aattttcaaa ttgttgagct gtttgccata atggatgatc agcaagcttt      120

gaactcaatc atgcaagatt tggctgtcct tcataaggcc agtcgaccag cattatcctt      180

gcaggaaacc agaaaagcaa aatcttcatc accaaaaaaa cagaatgatg tccgagtcaa      240

atttgaacat agaggagaaa aaagaatcct tcagttcccc agaccagtta aactggaaga      300

tctgagatct aaagctaaaa ttgcctttgg acagtctatg gatctacatt ataccaataa      360

cgagttggta attccattaa ctactcaaga tgacttggac aaagctgtgg aactgctgga      420

tcgtagtatt catatgaaga gcctcaagat attacttgta ataaatggaa gtacacaggc      480

tactaattta gaaccattgc catcactaga agatttggat aatacagtat ttggagcaga      540

gaggaaaaaa cggctatcta taataggtcc tactagtaga gatagaagtt ctcctccccc      600

aggttacatt ccagatgaat tacaccaggt tgcccggaat gggtcattca ctagtatcaa      660

cagtgaagga gagttcattc cagagagcat ggaccaaatg ctggatccat tatctttaag      720

cagccctgaa aattctggct caggaagttg tccatcactt gatagtcctt tggatggaga      780

gagctatcca aaatcacgaa tgcctagggc tcagagctac ccagataatc atcaggaatt      840

ttcagactat gataacccta tctttgagaa atttggaaaa ggaggaacat atccaagaag      900

gtatcatgtt tcatatcatc atcaagagta taatgatggt cgtaaaactt ttccaagagc      960

tagaaggacc caggggacca gcttacggtc tcctgtgagt ttcagtccta ctgatcattc     1020

cttaagcact agtagtggaa gcagtatctt taccccagag tatgatgata gtcgaataag     1080

aagaagggga agtgacatag acaatcctac tttgaccgta atggacatca gcccacccag     1140

ccgttcacct cgagctccga ccaactggag attgggcaaa ctgcttggcc aaggagcctt     1200

tggaagggtc tacctctgtt atgatgttga tacaggaaga gaattggctg ttaagcaagt     1260

tcaatttgac cccgatagtc ctgagaccag caaggaagta aatgcacttg agtgtgaaat     1320

tcagttgctg aaaaacttgc tacatgagcg aattgttcag tattatggct gtttgaggga     1380

tccccaggaa aaaacacttt ccatatttat ggaatatatg ccagggggtt caattaagga     1440

ccaattaaaa gcatatggcg ctcttactga gaatgtgact aggaaataca cccgtcagat     1500

tctggagggt gtccattatt tgcacagtaa tatgattgtc catagagata tcaaaggcgc     1560

aaatatcctg cgagattcaa caggcaacgt caaactagga gattttgggg ccagcaaacg     1620

gcttcagacc atctgtctct cagggacagg aatgaagtct gtcacgggca caccatactg     1680

gatgagccct gaagtcatca gtggagaagg ctatggaaga aaagcagaca tctggagtgt     1740

tgcatgtact gtggtagaaa tgctaactga aaagccgcct tgggctgaat ttgaagcaat     1800

ggctgccatc tttaaaatcg ccactcagcc aacaaaccca aagctgccac ctcatgtctc     1860

agactatact cgagatttcc tcaaacggat ttttgtagag gccaaactga gaccttcagc     1920

tgatgaactc ttaaggcaca tgtttgtgca ttatcactag cagccagtaa cctctcctgt     1980

gcctctacct agctcccatc tattcattca ccttctctct gactgcactt ttctttttta     2040

taaaaaaaga gagatggggg agaaaaaaga caagagggaa agtatttctc ttgattcttg     2100

gttaaatttg tttaataata ataatatcct aaatt                                2135


<210> 1269
<211> 5479
<212> DNA
<213> Homo sapiens

<400> 1269
cttggtgaag tgagattcag actgagtggg gtcacagcac agggcactgt cttgcctggc       60

tttatctgag ccaatcacac ctctcctggc cactatctgt ggtctagccc cctttgtgca      120

gaaagagaaa gaagagcctt gaggaccagc ctagtcaggc tgaagaaatg tcaacaattg      180

ggagttttga aggattccag gctgtgtctc tgaagcaaga gggagatgac caaccctctg      240

agactgacca cctatcgatg gaggaagagg acccgatgcc aagacagatt tcaaggcagt      300

caagtgtgac cgaatcaact ctttacccca atccttatca tcagccttat atctcacgga      360

agtactttgc tacacggccg ggggccattg agactgccat ggaagacttg aaaggtcacg      420

tagctgagac ttctggagag accattcaag gcttctggct cttgacaaag atagaccact      480

ggaacaatga gaaggagaga attctactgg tcacagacaa gactctcttg atctgcaaat      540

acgacttcat catgctgagt tgtgtgcagc tgcagcggat tcctctgagc gctgtctatc      600

gcatctgcct gggcaagttc accttccctg ggatgtccct ggacaagaga caaggagaag      660

gccttaggat ctactggggg agtccggagg agcagtctct tctgtcccgc tggaacccat      720

ggtccactga agttccttat gctactttca ctgagcatcc tatgaaatac accagtgaga      780

aattccttga aatttgcaag ttgtctgggt tcatgtctaa gcttgttcca gctatccaga      840

atgcccacaa gaattcaact ggatctggaa gaggaaagaa actgatggtg ttaactgaac      900

ccattttgat tgagacctac acagggctga tgtcattcat tggaaaccgc aacaaacttg      960

gctattccct tgcccgtggg agtattggtt tttgagagtc tttttggtac cataagcata     1020

tcatccacag atatgtcact ttgaaaattc cagtttgacc cacgctattt ttggactgaa     1080

acaattaatt atttttaaat gacgctttat gatttagaaa tttagtattt ccgaaaattt     1140

aaaagcttga ttggactgat agatacacac tttagacctc atacaagaat aatcaaattt     1200

tcttaaaact agaaaataaa tgctgctgag cctatcaaat actgttatca aatgagtgcc     1260

tgatcatcaa ctcaggaaag aagactctaa gtcctgttgc ttcagctctc taaatgtagg     1320

cttttttttt tttttttttt taggtcttgg tcttcagccc tcttatcctg atttattctc     1380

tcattggggt ctcactgtct ctagtatttt agctaccact tgataaggat gacttccaaa     1440

tttatattcc cattcccaat atttattcca agactcagtt ttgcatttct gactgctaat     1500

catctatata tcagtgtccc agtggcctct taattgagca ttatcaaaat cctgtggtat     1560

ttatatggtc ccagttatcc atccctgaag tctgtcaatt ttgatttctc taaattcctt     1620

gccatgacat cctatatatg atcacatctc tatacggctt agcattgtat tccgatgccc     1680

agatgtcaaa cttgaagctc attctcttat caaaattgtt catgtattcc tcctttccat     1740

tcttatagct gtattattag atcaggtttt taattctgct caaccaatta ttaccacagc     1800

ctgttaaatg gaatccctac tccaaggctg actgtttcaa tctatcctac acttggtttc     1860

tagctcattt acttatacca tcttttgttc aaatatatat tttttaataa cagacctttt     1920

tcttctaaag aaatcttttg tagaagcagc atatacgaag cagataaaag taggttcaat     1980

gcggttggag tgaagatgag aatgccacag gcatctttct ttctaggcct cagaggtgct     2040

gcatatggaa tgtccatgga tcgcagaggg ttttgaagac catgttttca aaaacactgt     2100

cttaacactc tattgtcatt gctcttttcc ctcttatttc ctctttgtct cttcccgact     2160

tagatctaat tttcaacaac ccaggaaatt atctcatatg tttgcatctc tcaagtttct     2220

tttctttttt ctttcagagt cttattttat ctaaatttat gtagaaaaaa aagctttgaa     2280

tgttgactac atagacatta ctacaataag ctttttgcct ttcccaagac tcaaaattga     2340

cacatctttg ttgatgttta agttgaaatt ccagccaact tttttttgac ttttatgtga     2400

agtttaaagt cttttctttg aaaagcttgc ttcctcaatt tcaaagattt gtcctctgat     2460

atatttataa acatcaattt aatgcagaca ttcaaaccct aaaccttgaa taactcttat     2520

tttattttgt ctttgtttac ttccattaat ttttttttct ttccctctct tccgccttta     2580

cagcacccac tttttcttcc ccccatgatg gcaaatattg ttatagtccc caaggcaggg     2640

aacttctatt cagactgtaa aaggaaatgt tgaaatccat agctgtcctg tcaacagtag     2700

tggaatgaaa agtcgttgga ttgttttggc actggttctg aagcaggcat aattggcaaa     2760

ttattataat actgctgccc gaaaatcccc atttgcctca agatagtggc atttattggc     2820

agaagcctct gaaatgtcca gcacattctt ttgagttacc atttaaggat cagcctgaca     2880

atcgacttct ctctgcacat ttgccccctt tgtaacctaa gccagactgt tcccaaatga     2940

ccttctaaag gacacagtgc accatcatca atggaaacag ttcagaaagg atgacaggag     3000

ggagatgttt cttagttctg agagccagtc tgtaacaatg ggataagcat ttaatggaat     3060

caaagctgtt ttgcataaag agtgaactca gagacgacaa gagggtcttt atgaattccc     3120

ttcacatttt gtaaaaactg tcatatatag gctatcccct taattgataa atgggatcta     3180

gaaagcggta ttatgaccag agggtgagaa gatttaggaa tttggatagc agttcaagat     3240

aagaaagaac ttcttatagt tataaatttt caatgatgga atgggttgct tctttaaaca     3300

gtgagcccac catcacttgg tatgttcaag gaaagactag ataaagtcga tattgtgaga     3360

ggaattgctg tatgataccg tttggagaaa tgattgacat aatcttttaa ggccggtgac     3420

cctatcattt tccaaataat tgttgctagt acttagttaa ttagacccat ttttttctta     3480

ggaaagagtt ggatcaatca tgggagaccc tgaaaaattt ccttaccttt cctaaggttt     3540

aatttcctct tctgcgaaat ggagacaatt atattacttt tgcttatttc ataaagatct     3600

tgtgaggatt caatgaaatg aggttaaatt cttttattaa acagaaagtt ttgagtattt     3660

gcctagagag tgatgtgact tttgcagcag aaggtgggaa aacatccaag ggaactacat     3720

ttcctccaga aattgtttct tcattaccat cgacctactg attatggttt tctcatttta     3780

cacttggtgt tcttacttgg gatctttgtc cttaagctca acagggagcc acaacccagg     3840

ggacctatgt gtacacttgg agtttttatc agactatcat ttgaacttac cactacagtt     3900

tagcaaatgg catgatgagt ttgattgata ataggagtag acgcaagata cattaagtag     3960

agtacaaagc atttcataac caaaatgtca tggttggagg tcttcattat tcggtcttta     4020

tctcattcag gaatttccac ttgaaaaatc tctgataagc tttatttcag aaactgcttg     4080

aacagctcca ctgacaaatg cctcactatc ttctgataca tcgtaggcag ttctgagggt     4140

gagaaagttc aaagcagata gatgttttaa cacaacagga ggacttttaa acaatcacca     4200

ggactcactc ctcggtggtc aattgggcct gtttggaggc ctgacctttg gtcatcttaa     4260

ggtcatctaa ggcagaaaag agaagctcac ttataagttg gcacttctga atcatttgcc     4320

ttgaggtcca ttttttattc agcctttgtt taaaccttct taggaagcca gtttgtagag     4380

ttctggggat aagaaggcag aaaaaccatg tcaattcagt gcttttattt cacagaaaat     4440

gaagcaaagg cctagaaact agaaagacat ttctcaaaaa gaagatggtg aacttttgga     4500

aatactgaga ttagactaca ttttccaatt tctatcccta gcccactgct ctttccaata     4560

taatatctgt attccatggg aaagacatgc catctgaatt gatgtatcgt agttgttgag     4620

ataattttga aatgagaaaa caatagggca cagtcgtttg ggaagaattt ccagaaattg     4680

ccatcatttt cttaaaggct aaggacactt atagagctct ccgatttcct atctgataaa     4740

aaaagcccaa acaaagctgc ggaagctggc agagccagca gatattttgt aaggcagctt     4800

cacctctgct ggcattttgt ggggcaggag agggggaggg caaaggtatt aaatttaggc     4860

ttaaaagctc ctcagaaatt ctttacacac aagagaccaa gttggagaaa agaagatgac     4920

ttgtgccaag gggaagaaag agagagacta atgcctgtgg ttttcaaagg ttaacaacaa     4980

cataaaaaag ccaaggtatt tgcacaggga tgaatgctca ttggctcttg gccaacaatt     5040

atacaagggc ttgtgcccac atcctgtagc tgtggtttag ggacgctgct catgagtgac     5100

ttcttatgct tagtggcagg aaactttagt cactgatgtg taaactcacc tttggtctgc     5160

acctcccaca acgtgctccg aaagcagtta ggggactagg cctcttgatt tccttgtaga     5220

taccagttcc ccagaagcta aggaaaaact ctgaggcctt ggagttactg agagtggacc     5280

aatacttgtc ttattctacc tgattttggc aactgcttag ggttcttctg tatccacaaa     5340

aaggaattat gatatcctct gctaaaccct ctctttagcc tcaaagccca agaccaaaaa     5400

aaatgagcca tatttcattg caggcctgct gccaatgtga aatataagga ataaagtcat     5460

gagactgctt ctcaaccta                                                  5479


<210> 1270
<211> 2606
<212> DNA
<213> Homo sapiens

<400> 1270
gatggcagcg gcagctgggg ctgcagcggc gccgggctct agagagccgc aggatcggcc       60

agagtgcgga gctggacacc cgggtcccag atactacaga cacccggaga ggtggctcct      120

tcgccctgaa gccttcctcg gccccctacg cactcgggcc ccttccgcag aggattcgca      180

gcgtgagcgc cccgcagccc gctcaggacc agctatgagc agacgtgtgg ttcggcaaag      240

caagttccgc catgtgtttg ggcaggcagc aaaggccgac caggcctacg aggacatccg      300

tgtgtccaag gtcacatggg acagctcctt ctgtgccgtc aaccccaaat tcctggccat      360

tattgtggag gctggaggcg ggggtgcctt catcgtcctg cctctggcca agacagggcg      420

agtggataag aactacccac tggtcactgg gcacactgcc cctgtgctgg atattgactg      480

gtgtccacac aatgacaacg ttatcgccag tgcctcagac gacaccacca tcatggtgtg      540

gcagattcca gactataccc ccatgcgcaa cattacggaa cctatcatca cacttgaggg      600

ccactccaag cgtgtgggca tcctctcctg gcaccctact gccaggaatg tcctgctcag      660

tgcaggtggt gacaatgtga tcatcatctg gaatgtgggc accggggagg tgctgctgag      720

cctggatgat atgcacccag acgtcatcca cagtgtgtgc tggaacagca acggtagcct      780

gctagccacc acctgcaagg acaagacctt gcgcatcatt gaccccagaa aaggccaagt      840

ggtggcggag aggtttgcgg cccacgaggg gatgaggccc atgcgggccg tcttcacgcg      900

ccagggccat atcttcacca cgggcttcac ccgcatgagc cagcgagagc tgggcctgtg      960

ggacccgaac aacttcgagg agccagtggc actgcaggag atggacacaa gcaacggggt     1020

cctattgccc ttttacgatc ccgactccag catcgtctac ctgtgtggca agggcgacag     1080

cagcattcgg tactttgaga ttaccgacga gccgcctttc gtgcactacc tgaacacgtt     1140

cagcagcaaa gagccgcagc ggggcatggg tttcatgccc aaaaggggac tggatgtcag     1200

caagtgtgag atcgcccggt tctacaagct acacgaaaga aagtgtgaac ctatcatcat     1260

gactgtgccc cgcaagtcag acctcttcca ggacgatctg tacccggata cgccaggccc     1320

ggagccggcc ctagaagcgg acgaatggct atccggccag gacgccgaac ccgtgctcat     1380

ttcgctgagg gacggctatg tgccccccaa gcaccgcgag ctccgggtca cgaagcgcaa     1440

catcctggac gtgcgcccgc cctccggccc ccgccgcagc cagtcggcca gcgacgcccc     1500

cttgtcgcag cacaccctgg agacgctgct ggaagagatc aaggccctcc gcgagcgggt     1560

gcaggcccag gagcagcgca tcacggctct ggagaacatg ctgtgcgagc tggtggacgg     1620

cacggactag ccccgcgcgc caggcaggcg gagcggggcg gggcgcacaa gctcggcccc     1680

gccccggctt ttagtcccga actccggacc ccgccttctt gggctgggcc cgggggcggg     1740

actggggagg gaactccgcc cctcgcggga gaccagaact cttggagctt aggggagacc     1800

cacgtcgctc cagcggaggc tggactgcga gcctcgtctg ggactcggct ggagctggcc     1860

tagggaggcc tggggtaacc tggggggctc agcaatggtg ctgcacggcg aggtggtgtc     1920

cccctttgtc ctccgcccag ggcagggaaa gtgcttagta ttagcgtgat gcttggggtt     1980

attggagcct gagcttgacc tcaaacgggt ggcgatttga tgggtacccc caggctgggg     2040

aaaatgacag cgcttctcct aatcagctca ctggattcca tcaccctgag cggtaaacca     2100

gatgggcgtc accccagttc tgcagacaca tacacaaccc gtttgctgca gagccggacc     2160

cagtggctac acccacagcg gtctgtggta gagaactctc ttccttcttt ccaccgacag     2220

gggcgagggc tgcttcctcg cggcagcccc cgcgaagaaa tctcgagaga actggcatga     2280

ggagttaggt tcatcacaaa tacacacaca ctgcccccaa ccctctgccg ttgcctctct     2340

cagaaaaaca agacgtactg aatgaaatat tttactaagc gttcagtctg tgcctcctgc     2400

atgggtggga gtgaggggaa cgagaccccc agcctctgca aatgctaccc ccaggctcct     2460

gggagacctg gcgatgcact cctgggctca gggtccatca ggcagcctct taccctagag     2520

ctctctccac tctgaggttc agaaggaccc caacccacac cgtaggcgtt ccccccaagt     2580

aaagttaggt agcaaaagcc tccggt                                          2606


<210> 1271
<211> 4384
<212> DNA
<213> Homo sapiens

<400> 1271
ggcggatctg tagtagttac cgcggcggcg ggagagcaag cgagccctgg ggggcaaaga       60

gacgggagag tgggtgtatg cgcgggtgaa gtgagaggta acggggctcc gggcggagag      120

gcctcagtgg ctcttgtcac cccttctcgc ggctgaacct ttggagccat ggtgaattcg      180

ggcctctccg aagccgccgc cgccgccacc gccactactg cctttaccgt ctcctaagag      240

tgaggagcgc ggacgaggta agcgaggagg cggcggctag agcggtggag acagcagcca      300

ccatgtcgga tacgcggcgg cgagtgaagg tctataccct gaacgaagac cggcaatggg      360

acgaccgagg caccgggcac gtctcctcca cttacgtgga ggagctcaag gggatgtcgc      420

tgctggttcg ggcagagtcc gacggatcac tactcttgga atcaaagata aatccaaata      480

ctgcatatca gaaacaacag gatacattaa ttgtttggtc agaagcagag aactatgatt      540

tggctctgag ttttcaggag aaagctggct gtgatgagat ctgggaaaaa atttgtcagg      600

ttcaaggtaa agacccatca gtggaagtca cacaggacct cattgatgaa tctgaagaag      660

aacgatttga agaaatgcct gaaactagtc atctgattga cctgcccaca tgtgaactca      720

ataaacttga agagattgct gacttagtta cctcagtgct ctcctcacct atccgtaggg      780

aaaagctggc tctcgccttg gaaaatgaag gctatattaa aaaactattg cagctgttcc      840

aagcttgcga gaacctagaa aacactgaag gcttacacca tttgtatgaa attattagag      900

gaatcttatt cctaaataag gcaactcttt ttgaggtaat gttttctgat gagtgtatca      960

tggatgtcgt gggatgcctt gaatatgacc ctgctttggc tcagccaaaa agacatagag     1020

aattcttgac caaaactgca aagttcaagg aagttatacc aataacagac tctgaactaa     1080

ggcaaaaaat acatcagact tacagggtac agtacattca ggacatcatt ttgcccacac     1140

catctgtttt tgaagagaat tttctttcta ctcttacgtc ttttattttc ttcaacaaag     1200

ttgagatagt cagcatgttg caggaagatg agaagttttt gtctgaagtt tttgcacaat     1260

taacagatga ggctacagat gatgataaac ggcgtgaatt ggttaatttt ttcaaggagt     1320

tttgtgcatt ttctcagaca ttacaacctc aaaacaggga tgcatttttc aaaacattgg     1380

caaaattggg aattcttcct gctcttgaaa ttgtaatggg catggatgat ttgcaagtca     1440

gatcagctgc tacagatata ttttcttatc tagtagaatt tagtccatct atggtccgag     1500

agtttgtaat gcaagaagct cagcagagtg atgacgatat tcttcttatt aatgtggtaa     1560

ttgaacaaat gatctgtgat actgatcctg agctaggagg cgctgttcag ttaatgggac     1620

ttcttcgtac tctaattgat ccagagaaca tgctggctac aactaataaa accgaaaaaa     1680

gtgaatttct aaattttttc tacaaccatt gtatgcatgt tctcacagca ccacttttga     1740

ccaatacttc agaagacaaa tgtgaaaagg attttttttt aaaacattac agatatagtt     1800

ggagtttcat atgtacccct tcacattccc attcccattc taccccctct tcctccatct     1860

ctcaagataa tatagttgga tcaaacaaaa acaacacaat ttgtcccgat aattatcaaa     1920

cagcacagct acttgcctta attttagagt tactcacatt ttgtgtggaa catcacacat     1980

atcacataaa aaactatatt atgaacaagg acttgctaag aagagtcttg gtcttgatga     2040

attcaaagca cacttttctg gccttgtgtg cccttcgctt tatgaggcgg ataattggac     2100

ttaaagatga attttataat cgttacatca ccaagggaaa tctttttgag ccagttataa     2160

atgcacttct ggataatgga actcggtata atctgttgaa ttcagctgtt attgagttgt     2220

ttgaatttat aagagtggaa gatatcaagt ctcttactgc ccatatagtt gaaaactttt     2280

ataaagcact tgaatcgatt gaatatgttc agacattcaa aggattgaag actaaatatg     2340

agcaagaaaa agacagacaa aatcagaaac tgaacagtgt accatctata ttgcgtagta     2400

acagatttcg cagagatgca aaagccttgg aagaggatga agaaatgtgg tttaatgaag     2460

atgaagaaga ggaaggaaaa gcagttgtgg caccagtgga aaaacctaag ccagaagatg     2520

attttccaga taattatgaa aagtttatgg agactaaaaa agcaaaagaa agtgaagaca     2580

aggaaaacct tcccaaaagg acatctcctg gtggcttcaa atttactttc tcccactctg     2640

ccagtgctgc taatggaaca aacagtaaat ctgtagtggc tcagatacca ccagcaactt     2700

ctaatggatc ctcttccaaa accacaaact tgcctacgtc agtaacagcc accaagggaa     2760

gtttggttgg cttagtggat tatccagatg atgaagagga agatgaagaa gaagaatcgt     2820

cccccaggaa aagacctcgt cttggctcat aaaatattta ttaggggacc ctcaacatgt     2880

ggtcttacaa tgctgcaact gttcagtgag ctgaaaatct gaatcagaaa gctttctcaa     2940

ttgaacttat aaaatataca aggagtagca aaagacagta tatcagctaa gagagtttag     3000

ttctaataaa aatcaggctt cccaggaact tgattgcttg ctagtaatta aggggtttgc     3060

cttttaggct gtcaaaacaa acattagtaa ccagaacctg ggagacagct tctcagcaag     3120

gaaaagtcac aggtttgggg acggtttagg ggaggggaaa aggttgatat aataatgcag     3180

ggttgctcct cggggtgtcg atctagaaac aattttacag aacttcagtt gtaaactcaa     3240

taacattact tgtataatgg tgctggccat gttgttgttt taatcagttg cctcttttta     3300

aaagaaattt ttatggaaaa cacattcaac tatcattaaa aaaatgaagt taagctgttg     3360

ggaccatttc tttaagattt aacaaaagtt cagcctttta ggtagttgaa gggaagtaca     3420

ccccgtattc agcacatgtt gagttttcta caccaggaat tttcaatatg tatattgatg     3480

aaaacaagct caattcaaac tggacagttt taagataatg ttaaaatcag cacttttaga     3540

gacaacgaag gccaagaatc agtacagtag tattccaaaa tgattttctc tagaaatttg     3600

aaagtagatc gaacagaatg ttgtcaaccg cctaccagta caatcttttg tggaagatac     3660

tttgaaatca ctttctactt tgttagtaaa gttctgtctt tccagagctg caagttttaa     3720

agtgttactt atacagacca accaagaata gtgctgaatt aagtggcatt tagtatctag     3780

aagccatttt gatccaagaa gctacttaag tgtcaaagtc agcatgcagc acatgtagct     3840

tttctgtaaa caagggtgtg atatgaaagc tgctttttta agaagagtaa aagcacattc     3900

catatacgta agtgaatttt aaaaataaat tgaggcaaac agttaagttt tatttttaga     3960

gcaacaagtt aactgtaaat attttaatgt tagtttgctc atctatgatc tgagatcatg     4020

ccgaagtgag aaaaatctcc ccaaaataca atttaatgca ttgggaaaaa aaaactttaa     4080

cagtaattcc agccacaatc tttagatcac ccttgtaatg tgttacgggt ccatttttcc     4140

tggaatcgtt taatctaaag cagtttcccc tgttttggag attttgtagt taattttaat     4200

tttggctatt gtttggaaaa gatgagctgt ctgtgtagat atgaagtata gttttttcca     4260

taaaacagat gtttattttg tattaaaaaa taccactgta cttgttttac accatttgta     4320

tacatgtggt gatattaatg ctaaactgta aaattcagga attaaaatgt gaccctgtaa     4380

ttcc                                                                  4384


<210> 1272
<211> 913
<212> DNA
<213> Homo sapiens

<400> 1272
gcggggcggc ggggcggccg gcggcggcca tgggagatat cccagccgtg ggcctcagct       60

cctggaaggc ttctccaggg aaagtgaccg aggcagtgaa agaggccatt gacgcagggt      120

accggcactt cgactgtgct tacttttacc acaatgagag ggaggttgga gcagggatcc      180

gttgcaagat caaggaaggc gctgtaagac gggaggatct gttcattgcc actaagctgt      240

ggtgcacctg ccataagaag tccttggtgg aaacagcatg cagaaagagt ctcaaggcct      300

tgaagctgaa ctatttggac ctctacctca tacactggcc catgggtttc aagcctcctc      360

atccagaatg gatcatgagc tgcagtgaac tttccttctg cctctcacat cctcgagtgc      420

aggacttgcc tctggacgag agcaacatgg ttattcccag tgacacggac ttcctggaca      480

cgtgggagat tttgatccga tttcaaatcc agaggaatgt gatagtgatc cccggatcta      540

tcaccccaag tcacattaaa gagaatatcc aggtgtttga ttttgaatta acacagcacg      600

atatggataa catcctcagc ctaaacagga atctccgact ggccatgttc cccataacta      660

aaaatcacaa agactatcct ttccacatag aatactgagg acgcttcccc ttccttgttt      720

ctgctcagcc cagatgcaca gacactattg gcaatgttga ccctcctctg tcatcacagc      780

gccagggcag ctgtgcctgg gacaggagcc acacagtcag agggggatgt aagagccacc      840

ttctctgaca aatctggaga attgagtgtg ttctaagtga aggcaatggg gtttctccaa      900

gacagcctgt gtg                                                         913


<210> 1273
<211> 3998
<212> DNA
<213> Homo sapiens

<400> 1273
aggctctttc ttctggggcc gggaaaaccg aggaatacac atgcgcagtt ggacccctca       60

ggcccttcgt gtcccttccc acccatctcc ccgccccggc cctctgggcg gggctgggcc      120

gacagtccag ctgcagctcg ctggagattc agtgacttcc ttgttgtgag ccccggcccg      180

gcagtgtccc gactcgtagc cccgctgttc ttaatccggg ccgctagcct gagtctaggt      240

cgcagccgca gccccacccc gtcggtcacc ttttcagcgc aggtcctttc cccgcacgcc      300

ctgcgctccc taacatgccc aaccccagca gcacctcctc tccctacccc ctccctgagg      360

aaattaggaa cctgttggca gatgttgaaa catttgtagc agatatactg aaaggagaaa      420

atttatccaa gaaagcaaag gaaaagagag aatcccttat taagaagata aaagatgtaa      480

agtctatcta tcttcaggaa tttcaagaca aaggtgatgc agaagatggg gaagaatatg      540

atgacccttt tgctgggcct ccagacacta tttcattagc ctcagaacga tatgataaag      600

acgatgaagc cccctctgat ggagcccagt ttcctccaat tgcagcacaa gaccttcctt      660

ttgttctaaa ggctggctac cttgaaaaac gcagaaaaga tcacagcttt ctgggatttg      720

aatggcagaa acggtggtgt gctctcagta aaacggtatt ctattattat ggaagtgata      780

aagacaaaca acagaaaggt gaatttgcaa tagatggcta cagtgtcaga atgaataaca      840

ctctaagaaa ggatggaaag aaagattgct gttttgaaat ctctgctcct gataaacgta      900

tatatcagtt tacagcagct tctcccaaag atgctgaaga atgggtacag cagctgaaat      960

ttgtattgca agatatggaa tctgatatta ttcctgagga ttatgatgag agaggagaat     1020

tatatgatga tgttgatcat cctctaccaa taagcaatcc actaacaagc agtcaaccaa     1080

tagatgatga aatttatgaa gaacttccag aagaagaaga ggacagtgct ccagtgaaag     1140

tggaagaaca aaggaagatg agtcaggata gtgtccatca cacctcaggg gataagagca     1200

ctgattatgc taatttttac cagggattgt gggattgtac tggagctttt tctgatgagt     1260

tgtcatttaa gcgtggtgat gtgatttaca ttcttagcaa ggaatacaat agatatggct     1320

ggtgggtagg agaaatgaag ggagccattg gcttggtgcc taaagcctac ataatggaga     1380

tgtatgatat ttgagagtcc tggaaaagga aaattcttct gcttgtctgc aaatgctttg     1440

gatttagaag cgtcatgaaa gcacgagtga cagctcctaa cctctccttg ttttattaaa     1500

cattacttat ctttgactgt tattttatgc agtcgctcat taaaatattc ctctgatgtg     1560

aaattaaatg aaggatatta atgtaaatta gatgcaacca gttaagttat acctgttgct     1620

attttgcaaa gaaataatta tagtttttat ttacccattt gatttgtgtg aagaattcat     1680

cactatttta tacgtaacat atagtctact atagcatagt atgctactat tgctacttct     1740

ggtgtgattt gtaatgtttc ttaatcattg gacatcaatt atttttagag agtaatgtat     1800

aatttcatag cattttaaat ttagtgtatc atgcgagttt tttttggtag atgctgaaga     1860

atgtggttgc taaacaaaga atgctaaaga atgttcaaac tttatagata actttattgt     1920

tattatttat tttcacacat ttaattccta ttaagtacag ccgcaagaaa gaaaaaatga     1980

tgaagttgca aatggcagtg tgctgtcacc tgcaacagaa gtgcgtacca gaagtatgac     2040

tcatgcaaag cattttaccg tacaaatatc ctggtgcgat gatgggcctg gcaacatttt     2100

ctactgtact tttgtttaaa tttaatgaaa caaaaaattc ctaagaaata ccaccctacc     2160

actaacaaaa tggtataaag aatctcccag ccaggccaac atggtgaaac cctgtctcta     2220

ctaaaaatta gccaagtgtg gtaatgttca cctgcagtcc cagctacttg ggaggccaag     2280

gcacgagaat tgcttgaaca aggtaggcag aggttgcagt gagccaagat cgcgccactg     2340

cactccagcc tgggcgacag agtgagactc catctcagaa aaaaaaaaaa aaaaaaacag     2400

aatctcagtg tattctcaaa gtaaaaaggc ataaccaagc actctcttat cttgccttat     2460

tgctatacta tttacatccc actgcagaac agcagatttg aggcttttct atatacttct     2520

cagagcactg aaaagaaagg aagggtttgc agaggagagt gtagaaatcc cagtggtagc     2580

atgtaccaac aggtgagtag aaaggtagtg ttagcctgac atttgagtta tactctgtgc     2640

tgcctgagca agatttgtag aatcatataa ttaccttttc atgtatattt gaaatcagag     2700

gtgtttaaaa tacctatgag ataccaatgt agccttaaca tatgtcaaaa tgcattgctg     2760

gttagataat tatttggact acacataaac tcctaatatt gaatcattac ctatcaggta     2820

ttatctttat ggaacttttc aatatctttg ctttataaag attctaaaca tgtatctgag     2880

ctggtaatat tttaaaatct ccattatttg tgtaaaactg tttataagca gtgtttgaga     2940

gggtctgctt taccattacc ccctcaatat catgatcatc caatctcaaa tgtgaaaaaa     3000

aaaaagaaat ttgattttag ggattgtgag taaacaagtt tatatagaga gacattgtga     3060

agttaaagtt ttcagaagtt acatttgtgc agttcttacc ttttcctcat atagtgccat     3120

tgaaatagac tgaaattatc ttggcaaaag ttagacaacc aaagacgact ttagtggact     3180

ggttttcaaa acttgagcag ctgaaaagca aaagccgttg tttcccatga caatgtagcc     3240

tttgtggatt tgggtttgtg ctttgggttg aaaagaagtt tttagtccta ggccagtaga     3300

tggcagcagc ttttcattgc agacaaaacc tcttgaaacc cttcccccat ggcacaaact     3360

cgcccatgat ggaaagcatc tagatttctg cctcctttta cagttaatcc aggagaggga     3420

gtcctttgcc aactgatgac caacagttcc aagccagata gtctcgtgaa cagtgacaat     3480

acagaaataa ggtgttattt ctgttcagat ctccaccggc ctttgttctt ttaaaacttg     3540

aatataggtg ggagacataa gaaaggaaag aaaagactta aaactggagt gacaggacaa     3600

ataatcatta ctttcaattc atgactgctt tatattcatt tgatgaaatc atttgtatac     3660

aaaccaggga gagttttctt tacacccttg acaatatatc acatactctt caagatcata     3720

ataatatcat taatataaat ttaaacaaca tggcttgtta gaaaatatgc taattgctat     3780

ggtctcatta tgtttgctta gcttttattt gtttttctgt gaacagttag agagctaatt     3840

tttttcaaag gtgattgtaa gtcatatttt atatagcatt ttgcttgatt atttgctctg     3900

tactgaattt gtactctatt gccattagat cttacaataa tgttccactc tgcaaatttt     3960

taaggttcaa ataaagttta attgtttgca aactgtta                             3998


<210> 1274
<211> 1475
<212> DNA
<213> Homo sapiens

<400> 1274
attggccgag cgcggccgtt gggggtgagg ccgcgtcggg ggaggacaac aaagggccgc       60

gggcggcggg cagtggtgtc ccagtctccc ggtgcttccc tgaggctgag gcgcccggcc      120

tcccgcccgc cgcgctccag atgaagtgtg agcactgcac gcgcaaggaa tgtagtaaga      180

aaacaaaaac tgatgaccaa gagaatgtgt cagccgatgc accgagtcca gcccaggaaa      240

atggagagaa atgtgatacc tcaaagcaca aagtgctggt agtgtctgtg tgtcctcaat      300

ctttgcctta ttttgctgct aaattcaacc tcagtgtaac tgatgcatcc agaagactct      360

gtggtttcct caaaagtctt ggggtgcact atgtatttga tacgacgata gctgcggatt      420

ttagtatcct ggagagtcaa aaagaattcg tgcgtcgcta tcgccagcac agtgaggagg      480

aacgcaccct gcccatgctg acctctgcct gtcctggctg ggtccgatac gccgagcggg      540

tgctgggtcg ccccatcact gcccacctct gcaccgccaa gtccccccag caggtcatgg      600

gctctttggt gaaggattat ttcgccagac agcagaacct gtctccagag aagattttcc      660

acgtcattgt ggccccttgt tatgacaaga agctggaggc tcttcaggaa agccttcccc      720

ctgctttgca tggctcccgg ggcgctgact gcgtgttaac atcaggtgaa attgctcaaa      780

taatggagca aggtgacctc tcagtgagag atgctgccgt cgacactctg tttggagact      840

tgaaggagga caaagtgacg cgtcatgatg gagccagctc agacgggcac ctggcacaca      900

tcttcagaca tgcggccaag gagctgttca acgaggatgt ggaggaggtc acttaccgag      960

ccctgagaaa caaagacttc caagaggtca cccttgagaa gaacggagag gtggtgttac     1020

gctttgctgc agcctatggc tttcgaaaca tccagaacat gatcctgaag cttaagaagg     1080

gcaagttccc attccacttt gtggaggtcc tcgcctgtgc tggaggatgc ttaaatggca     1140

gaggccaagc ccagactcca gacggacatg cggataaggc cctgctgcgg cagatggaag     1200

gcatttacgc tgacatccct gtgcggcgtc cggagtccag tgcacacgtg caggagctgt     1260

accaggagtg gctggagggg atcaactccc ccaaggcccg agaggtgctg cataccacgt     1320

accagagcca ggagcgtggc acacacagcc tggacatcaa gtggtgaagt caggccaggg     1380

ccttccagct gctcttgggg ccagagccaa gagcctctca gtagagggag gggctgccct     1440

gagtggagta ttaaagacac ttaagaaaac cgctc                                1475


<210> 1275
<211> 4669
<212> DNA
<213> Homo sapiens

<400> 1275
tgaaggtaaa attttccaga tacggcagac ggctttcaga gtacaataaa cagggaatga       60

gaactattta catggaagtt tctttctcat gatgcggtgg agaagcctcg gccacttggt      120

tctgccagat gttcctgggg ttactgtaaa tgggaaggac aggcagagct aaacaaggtt      180

tatcatttaa aagtgcctgt gtgaagtcac ttttgctgga aaactgcagc ttgggagctt      240

tctttgtatt cacatcccac tcttctgtca agtacacttt accctgacct tatgagtgga      300

tgaagatacc tcagttgtct gactttgcca attgcttaat ttcagaattt aaaaagggga      360

aagaaaaaca tcctgctaaa atatgaacat ctgagtgtct tattttccaa catcgtcaat      420

agctgtgagc gtcagcatta aatattctcc caaggagtgc catgatattg aagtcacttt      480

attaataaca gctgtatctg caaaacagtc aagagactcg gacgttgaaa gccagagatg      540

acactgagca tgcttttatt gcggcctacc atctttaagt gggacatatt gattgatgag      600

tgattgcctg tccatacact ctctcatcat cctgttcctt ggattggact tcactaagca      660

atttatcact caccttcaga cttacatgtg ggagttttca caacagtagt tttggaatca      720

ttagaacttg gattgatttc atcatttaac agaaacaaac agcccaaatt actttatcac      780

catggctttg aacgttgccc cagtcagaga tacaaaatgg ctgacattag aagtctgcag      840

acagtttcaa agaggaacat gctcacgctc tgatgaagaa tgcaaatttg ctcatccccc      900

caaaagttgt caggttgaaa atggaagagt aattgcctgc tttgattccc taaagggccg      960

ttgttcgaga gagaactgca agtatcttca ccctccgaca cacttaaaaa ctcaactaga     1020

aattaatgga aggaacaatt tgattcagca aaaaactgca gcagcaatgc ttgcccagca     1080

gatgcaattt atgtttccag gaacaccact tcatccagtg cccactttcc ctgtaggtcc     1140

cgcgataggg acaaatacgg ctattagctt tgctccttac ctagcacctg taacccctgg     1200

agttgggttg gtcccaacgg aaattctgcc caccacgcct gttattgttc ccggaagtcc     1260

accggtcact gtcccgggct caactgcaac tcagaaactt ctcaggactg acaaactgga     1320

ggtatgcagg gagttccagc gaggaaactg tgcccgggga gagaccgact gccgctttgc     1380

acaccccgca gacagcacca tgatcgacac aagtgacaac accgtaaccg tttgtatgga     1440

ttacataaag gggcgttgca tgagggagaa atgcaaatat tttcaccctc ctgcacactt     1500

gcaggccaaa atcaaagctg cgcagcacca agccaaccaa gctgcggtgg ccgcccaggc     1560

agccgcggcc gcggccacag tcatggcctt tccccctggt gctcttcatc ctttaccaaa     1620

gagacaagca cttgaaaaaa gcaatggtac cagcgcggtc tttaacccca gcgtcttgca     1680

ctaccagcag gctctcacca gcgcacagtt gcagcaacac gccgcgttca ttccaacagg     1740

gtcagttttg tgcatgacac ccgctaccag tattgtaccc atgatgcaca gcgctacgtc     1800

cgccactgtc tctgcagcaa caactcctgc aacaagtgtc cccttcgcag caacagccac     1860

agccaatcag ataattctga aataatcagc agaaacggaa tggaatgcca agaatctgca     1920

ttgagaataa ctaaacattg ttactgtaca tactatcctg tttcctcctc aatagaattg     1980

ccacaaactg catgctaaat aaagatgtag ttcttctgga cagaccacaa ctctaagaag     2040

ctagtgctgc tatctcatat atgagtatta aatatggtat gcttagtata ttccaaccta     2100

agatagttaa ctacctgaga ccagctgtga tgtttaaaga cataaaggat aaagtttact     2160

tttaaagggt ttctaaacat agtttctgtc ctaggaatat tgtcttatct ccataactat     2220

agctgatgca gaaagtccag ccagtttact catttcgatt cagaatattt caaatttagc     2280

aataaacaat tagcattagt taaaaaagaa acatattcca agggcaggtt cgattctagc     2340

tctaattact gtcatgtcat ttacccactg gatcaaaggg tatgtttcac ttcttgacaa     2400

tataaatgct gcagcaaaga tgagaggtga agtaaaaccg atacctgtcc tgcaggtcta     2460

aaatttgaat ggaaattcaa gcacaagtac tggggacaca tcaaagtgtg gtgtttggtt     2520

tgcctggaga tgccacgttg aatcatgtga ttctagatta acattaaata gattgaaaaa     2580

gaaactttgc acggtatgag cttcataccc caccaaacaa agtcttgaag gtattatttt     2640

acaagtatat ttttaaagtt gttttataag agagactttg tagaagtgcc tagattttgc     2700

cagacttcat ccagcttgac aagattgaga ggcccatgcc aacagtctaa tctaagagat     2760

tagtctttca aactcaccat ccagttgcct gttacagaat aactcttctt aactaaaaac     2820

ctagtcaaac aaggaagctg taggtgagga gatctgtata atattctaat ttaagtaagt     2880

ttgagtttag tcactgcaaa tttgactgtg actttaatct aaattactat gtaaacaaaa     2940

agtagatagt ttcacttttt aaaaaatcca ttactgtttt gcatttcaaa agttggatta     3000

aagggttgta actgactaca gcatggaaaa aaatagttct tttaattctt tcaccttaaa     3060

gcatatttta tgtctcaaaa gtataaaaaa ctttaataca agtacataca tattatatat     3120

acacatacat atatatacta tatatggatg aaacatattt taatgttgtt tactttttta     3180

aatacttggt tgatcttcaa ggtaatagcg atacaattaa attttgttca gaaagtttgt     3240

tttaaagttt attttaagca ctatcgtacc aaatatttca tatttcacat tttatatgtt     3300

gcacatagcc tatacagtac ctacatagtt tttaaattat tgtttaaaaa acaaaacagc     3360

tgttataaat gaatattatg tgtaattgtt tcaaacatcc attttctttg tgaacatatt     3420

agtgattgaa gtattttgac ttttgagatt gaatgtaaaa tattttaaat ttgggatcat     3480

cgcctgttct gaaaactaga tgcaccaacc gtatcattat ttgtttgagg aaaaaaagaa     3540

atctgcattt taattcatgt tggtcaaagt cgaattacta tctatttatc ttatatcgta     3600

gatctgataa ccctatctaa aagaaagtca cacgctaaat gtattcttac atagtgcttg     3660

tatcgttgca tttgttttaa tttgtggaaa agtattgtat ctaacttgta ttactttggt     3720

agtttcatct ttatgtatta ttgatatttg taattttctc aactataaca atgtagttac     3780

gctacaactt gcctaaaaca ttcaaacttg ttttcttttt tctgtttttt tctttgttaa     3840

ttcatttaaa ctcattgaaa acatagtata cattactaaa aggtaaatta tgggaatcac     3900

tgaaatattt ttgtagatta attgttgtaa cattgtcttt cttttttttc ttttgtttca     3960

tgattttgat ttttaaaatt attagcacac aactattttc agccctttaa taatggagca     4020

tcaaaaacat cacctgtaac cccaagcaaa tatagaagac tgtatttttt actatgatat     4080

ccattttcca gaattgtgat tacaatatgc aaagagtcat aaatatgcca tttacaataa     4140

ggaggaggca aggcaaatgc atagatgtac aaatatatgt acaacagatt ttgcttttta     4200

tttatttata atgtaatttt atagaataat tctgggattt gagaggatct aaaactattt     4260

ttctgtataa atattatttg ccaaaagttt gtttatattc agaagtctga ctatgatgaa     4320

taaatcttaa atgctttgtt taattaaaaa acaaaaatca ccaatatcca agacatgaag     4380

atatcagttc aacaaatact gtagttaaga gactaactct ccacttgtat gggaactaca     4440

tttcactctt ggttttcagg atataacagc acttcaccga aatattcttt cagccatacc     4500

actggtaaca tttctactaa atctttctgt aacacttaaa gaattccctc attcattacc     4560

ttacagtgta aacaggagtc taatttgtat caatactatg ttttggttgt aatattcagt     4620

tcactcaccc aatgtacaac caatgaaata aaagaagcat ttaaaagga                 4669


<210> 1276
<211> 5062
<212> DNA
<213> Homo sapiens

<400> 1276
gataaggtgg cggcggcgaa ggcagcggca ggtcgggagc aagatggcgc tgcggccagg       60

agctggttct ggtggcggcg gggccgcggg agctggcgcg gggtccgccg ggggaggcgg      120

cttcatgttt cctgttgcag gtgggataag accccctcaa gcaggcctga tgccgatgca      180

gcaacaagga tttcctatgg tctctgtcat gcagcctaat atgcaaggca ttatgggaat      240

gaattacagc tctcagatgt cccaaggacc tattgctatg caggcaggaa taccaatggg      300

accaatgcca gcagcgggaa tgccttacct aggacaagca cccttcctgg gcatgcgtcc      360

tccaggccca cagtacactc cagacatgca gaagcagttt gccgaagagc agcagaaacg      420

atttgaacag cagcaaaaac tcttagaaga agaaagaaaa agacgccagt ttgaagagca      480

gaagcaaaag ctcagacttt tgagcagtgt gaaacccaag acaggagaga agagtagaga      540

tgatgctttg gaagccataa aaggaaattt agatgggttt tccagagatg caaaaatgca      600

ccctactcca gcatcgcacc ccaagaaacc aggcccttcc ttggaggaga agttcctagt      660

atcttgtgat ataagtacat ctgggcagga acaaattaaa ttaaatactt ctgaagttgg      720

ccacaaagcc ctaggcccag gttccagtaa gaagtatccc agtttaatgg ccagtaacgg      780

ggttgctgta gatggatgtg taagtggtac caccactgca gaggcagaaa atacttcaga      840

tcaaaacctg tcaattgaag agagtggtgt gggagtattt ccctcacagg atcctgctca      900

gcccagaatg cctccttgga tttacaatga gagtttggtt ccagatgcct ataagaaaat      960

cttagaaacc acaatgactc caactggaat agatactgcc aaactgtatc ccattctgat     1020

gtcatctggg cttcccaggg aaactcttgg acagatatgg gccttagcta atcgaactac     1080

acctggcaaa cttacaaaag aagaacttta taccgttcta gccatgatag cggtaacaca     1140

gaggggcgtt cctgcaatga gtcctgatgc tttaaaccag ttcccagcag ctcctattcc     1200

aactttaagt ggcttttcta tgactctgcc tacaccggtg agtcagccaa ctgtgatacc     1260

ttcaggtcct gcgggctcca tgcccctcag ccttggacag ccagtcatgg gcattaacct     1320

tgttggacca gtgggtggag ctgcagccca ggcttctagt ggtttcatac caacctaccc     1380

tgcaaatcag gtagtaaagc cagaagaaga tgacttccag gattttcaag atgcttctaa     1440

gtcaggatcc cttgatgact cattcagtga tttccaagag ttgcctgctt cttcaaaaac     1500

aagtaactcc cagcatggaa acagtgcccc ttctttgttg atgccacttc ctggaactaa     1560

agcattgcct tcaatggaca aatatgctgt gtttaaagga attgcagctg acaagtcctc     1620

tgaaaatact gttccacctg gagatcctgg tgataaatat agtgctttca gagaacttga     1680

acagacagca gagaataaac ctttaggaga aagctttgca gaattcagat ctgcaggaac     1740

tgatgatggt ttcaccgatt ttaaaacagc cgatagtgta tcaccactag agccaccaac     1800

aaaagacaaa acttttccac catccttccc ctcaggaact atacaacaga aacaacaaac     1860

acaagtgaaa aaccctctga acttagcaga cctagatatg ttttcctcag ttaattgcag     1920

cagcgagaaa ccattgtctt tttcagctgt gtttagcaca tcaaaatcag tttctacacc     1980

acagtcaaca ggttctgctg ctactatgac agcattggca gcaacaaaaa cttctagttt     2040

ggctgatgat tttggagaat tcagcctttt tggggaatat tctggtctag cacctgttgg     2100

ggagcaggat gactttgcag attttatggc tttcagtaat agctctattt catctgagca     2160

aaagccggat gacaaatatg atgcccttaa agaggaagcc agtcctgttc ctctaaccag     2220

caacgtgggc agcacagtga agggtggaca aaactcgact gctgcgtcta ccaagtacga     2280

tgtcttcaga caactttctc tggaagggtc tggactaggt gttgaagacc tgaaagataa     2340

cactccttca ggaaaaagtg atgatgattt tgctgacttc cactccagta aattttcttc     2400

cataaactcg gacaaatccc tgggagagaa agcagtggct ttcagacaca ccaaagaaga     2460

ctctgcatca gtgaagtcct tagatctccc ttccattggt ggcagcagtg ttggcaagga     2520

ggactctgaa gatgcactct ctgttcagtt tgacatgaaa ttggctgatg tgggaggaga     2580

tcttaagcat gtcatgtctg atagctcttt ggatttacca acagttagtg gccagcatcc     2640

tcctgctgca gatatagagg acttaaaata tgctgctttt ggaagctaca gtagcaattt     2700

tgcagtgagc acacttacaa gctatgactg gtcagacagg gatgatgcaa ctcagggcag     2760

aaaactctct ccatttgtcc tctcagcagg aagtggatcc ccctcagcca cctcaattct     2820

tcaaaagaaa gagacttcat ttggcagttc tgaaaacatc accatgacat ctctctccaa     2880

agtaacgacc tttgtaagtg aagatgctct tccagagacc accttcccag ctcttgccag     2940

ttttaaagac acgattcctc agaccagtga gcaaaaggaa tatgaaaaca gagactataa     3000

agatttcaca aaacaggacc tgcctacggc tgaacggagc caggaggcca cgtgtcccag     3060

cccagcgtcc agtggtgcct ctcaagaaac cccgaacgaa tgttcggatg actttggaga     3120

gtttcaaagt gaaaagccca aaatcagcaa atttgacttc ttagtagcca cttcacaaag     3180

caaaatgaaa tccagtgaag aaatgatcaa aagtgagctg gcaacctttg acctttctgt     3240

tcaaggatca cacaagagga gtttgagcct tggtgataaa gaaataagcc gttcttctcc     3300

ttctccagct ttggagcagc ctttcagaga ccgttccaat actctgaatg agaagcccgc     3360

cctgcccgtc atccgagaca agtacaaaga cctgacggga gaggtggagg aaaatgagag     3420

atatgcatat gaatggcaga gatgcctggg gagtgccctg aatgtcatta agaaggcaaa     3480

tgatacctta aatggaatca gtagtagttc tgtttgcaca gaagtaattc agtcagctca     3540

aggcatggaa tatttattag gtgttgttga agtgtacagg gtaaccaagc gtgtggagct     3600

ggggataaaa gccactgcag tgtgcagtga gaaactccag cagttgctga aggacatcga     3660

taaagtatgg aataacctaa tcggcttcat gtcactcgcc acactcacac cagatgaaaa     3720

ctcgctggat ttttcctcct gtatgttacg gcctgggatt aaaaatgctc aggagcttgc     3780

ctgtggagtg tgcctcttga atgtggactc gaggagccgg gcattcaact cagaaacaga     3840

cagtttcaag ctggcctatg gagggcacca gtatcacgcc agctgtgcca acttctggat     3900

caactgtgtc gaaccaaagc ctcctggcct cgtcctgcct gacctgctct gaacaactcc     3960

tctgtgaagc attgactttt ttttttctgt gacaccccac ggggtgacag ggaccaataa     4020

atagaatgcg agcactgcac agttcgcttc cctgaatcga tatgaagaac accgcaaggg     4080

acggggcccc cgtcatcccc acggccagtc tgcaggactt caggtaaaat tgtcccaccc     4140

aaactgcacg tggcaccaga agcttgctca cttatctcta cttaagattt tctgaaatac     4200

ggaccacggc tttcttgatc taaggaagaa cttgctgctg cagtattgaa actgtgaaga     4260

actgacattt gaagaaaaat agattaccgt tgcgggacta gaatgggcga ctgcttggag     4320

ccagtgcttg tttttatcta ggacacttac tgtcctgtga agtagaatac atttatctgc     4380

atttagtttg ttaatgtctg aaatgaataa aaagaggaaa ttgcgattaa actgatgttc     4440

tgctttttat ggagaagatt ctgcccatct cccctggaca gtagcaggca ggtgagggca     4500

gattttaccc acttggttgt cacaactgaa ccagttctct actccttccc ttcacttctg     4560

tccactctca agactttttc ccaaaacatg cctgggcact ctgcagccgt gaagaatgct     4620

cattttgaca gaggcccaaa tcctgtgtat taggataata tccttccccc cgggagcctt     4680

cgctgcaaac ctgttctgcc gcatgcaaag actgtgacca tggagttttc tcagacaaga     4740

tttggaaagg cagtggaatg aaatctcttt gcagtggcct ctctccaaat ttccaaagat     4800

gactgcatag ggaccaacac tgcctgactt tgcagtatct gtgagaaaaa cctgaaaatt     4860

aattcagggt gaaaatgtgg agctctcggc ctagtgtaaa gtatcaagat gtatatttat     4920

gggatagata catgacttag aagaagtaga agaaaattgt ccagaaacag tactgaattt     4980

tagatagaaa aggctcatgc ttcctggagt agggaattgt ctttgccatt taatgtgaat     5040

gcataaaatt aggggaaaaa cc                                              5062


<210> 1277
<211> 2129
<212> DNA
<213> Homo sapiens

<400> 1277
ggagttgcag tttgagagca gttccgggca gggaggcgcc tttgctgccc tcacagactt       60

ggcccctagc agtgcagaac tacaagtccc agggatccta gcgaccgtcc gtccgtagtc      120

aagttgccgg tggaattggc ccaggatgac agctggagaa tggagtcagt tttatccaag      180

tatgaagatc agattactat tttcactgac tacctagaag aatatccaga tacagatgag      240

ctggtatgga tcttagggaa gcagcatctc cttaaaacag aaaaatctaa gctgttgtct      300

gatataagtg ctcgtctatg gtttacatac agaaggaaat tttcaccaat tggtggaacg      360

ggcccttcat cagatgctgg ttggggatgt atgctacgct gtggacagat gatgctggct      420

caagccctta tctgtagaca cttgggaagg gactggagct gggagaaaca aaaagaacaa      480

cccaaagaat accaacgcat cctacagtgc ttcttagata gaaaagattg ttgctactct      540

atccatcaaa tggcacaaat gggtgtagga gaagggaaat caattggaga atggtttgga      600

ccaaatacag ttgcacaggt gttaaaaaaa cttgctttat ttgacgaatg gaattccttg      660

gctgtttatg tttcaatgga taacacagtg gtcattgaag atatcaaaaa aatgtgccgt      720

gtccttccct tgagtgctga cacagctggt gacaggcctc ccgattcttt aactgcttca      780

aaccagagtg acgagctcat cttcttggac cctcatacaa cccagacctt tgttgacact      840

gaagagaatg gaacggttaa tgaccagact ttccattgcc tgcagtcccc acagcgaatg      900

aacatcctaa acctggatcc ttcagttgca ttgggatttt tctgcaaaga agaaaaagac      960

tttgataact ggtgtagcct tgttcagaag gaaattctaa aggagaattt aaggatgttt     1020

gaattagttc agaaacatcc atcacactgg cctccctttg tacctccagc caagccagaa     1080

gtgacaacca ctggggcaga attcattgac tctactgagc aactggagga gtttgatctg     1140

gaggaagatt ttgagattct gagtgtgtag aatcctggga actcaacttg aaggtctgtc     1200

ttccatctgg caccataaaa acatgaactt attgcataaa acttttctag tcagcaagtg     1260

cctgatatgc caatagcata caaactcaat agcaatcatg actgagccaa tcactgtttc     1320

tcagaaaaac aaaacaaaac aaaacaaatg acagtaaccc ttccccggaa agaaatagaa     1380

caatcatgga gcctaggagc agagagatga ggaggagttc attgcttccc agcttgtgtt     1440

atatggctac agcaagtctt cagctgctgc aatgaggaaa tgggcatctg gaagacaaac     1500

agcaactctc agcttgcttc aagaaccagc agataagaga tggttaagct gttcttcacc     1560

ctttcagatg tgacctcttt tggactaagc agcaatctgt tctcttgctc aaataataaa     1620

gtgactgaat cagggaggaa aaggttcttg ttaaattatt tgattgtgta gttgaagtaa     1680

ttataattta tatcaaaacg tttgtcaaag aaacgatgtc aaatatacac ttcttgatct     1740

cccttctgtt tgcggggatc ttactatttg atgggtcact gtccccattc ttactgatac     1800

ttttgtcaga tatcaccctg tccttaaatc atgatcactt aaatcagggg tcagcaaact     1860

ttttctgtaa agggccagac gggaaatatt ttgggctttg caggccatgc ggcctctgtc     1920

acatctactc aactctgctg ttgacatgca aaagcagcaa tagacaatat gcgtgtaaat     1980

gagtgtggct gtaatccaag aaaactttat ttacaaaagc aggtggaggg ctgggtttgg     2040

cctgcaggct gtagcttgcc aatcagtgac ttaaattgtt gatttttgtt tgataaatta     2100

aaaataaatt gtgtttgaag tatacccta                                       2129


<210> 1278
<211> 3544
<212> DNA
<213> Homo sapiens

<400> 1278
attggtgagt ggggcagggc aggagggaac tgaagagtga gaaagcatta tttcagcaaa       60

aggtctttcc tcccttgctc tctcctccaa ccactggctc agcctctccg cccgctgcct      120

gtgaatgatg caatggaagg tgtgctgggg tcgccctgtg tcccgtgcat aggagcatct      180

cagcctccag gtcctctcct ttggggctca cggcaccccc atgctacgaa ccgcaggcag      240

ggacggcctc tgtcgcctgt ccacctactt ggaagaactc gaggctgtgg aactgaagaa      300

gttcaagtta tacctgggga ccgcgacaga gctgggagaa ggcaagatcc cctggggaag      360

catggagaag gccggtcccc tggaaatggc ccagctgctc atcacccact tcgggccaga      420

ggaggcctgg aggttggctc tcagcacctt tgagcggata aacaggaagg acctgtggga      480

gagaggacag agagaggacc tggtgaggga taccccacct ggtggcccgt cctcacttgg      540

gaaccagtca acatgccttc tggaagtctc tcttgtcact ccaagaaaag atccccagga      600

aacctacagg gactatgtcc gcaggaaatt ccggctcatg gaagaccgca atgcgcgcct      660

aggggaatgt gtcaacctca gccaccggta cacccggctc ctgctggtga aggagcactc      720

aaaccccatg caggtccagc agcagcttct ggacacaggc cggggacacg cgaggaccgt      780

gggacaccag gctagcccca tcaagataga gaccctcttt gagccagacg aggagcgccc      840

cgagccaccg cgcaccgtgg tcatgcaagg cgcggcaggg ataggcaagt ccatgctggc      900

acacaaggtg atgctggact gggcggacgg gaagctcttc caaggcagat ttgattatct      960

cttctacatc aactgcaggg agatgaacca gagtgccacg gaatgcagca tgcaagacct     1020

catcttcagc tgctggcctg agcccagcgc gcctctccag gagctcatcc gagttcccga     1080

gcgcctcctt ttcatcatcg acggcttcga tgagctcaag ccttctttcc acgatcctca     1140

gggaccctgg tgcctctgct gggaggagaa acggcccacg gagctgcttc ttaacagctt     1200

aattcggaag aagctgctcc ctgagctatc tttgctcatc accacacggc ccacggcttt     1260

ggagaagctc caccgtctgc tggagcaccc caggcatgtg gagatcctgg gcttctctga     1320

ggcagaaagg aaggaatact tctacaagta tttccacaat gcagagcagg cgggccaagt     1380

cttcaattac gtgagggaca acgagcctct cttcaccatg tgcttcgtcc ccctggtgtg     1440

ctgggtggtg tgtacctgcc tccagcagca gctggagggt ggggggctgt tgagacagac     1500

gtccaggacc accactgcag tgtacatgct ctacctgctg agtctgatgc aacccaagcc     1560

gggggccccg cgcctccagc ccccacccaa ccagagaggg ttgtgctcct tggcggcaga     1620

tgggctctgg aatcagaaaa tcctatttga ggagcaggac ctccggaagc acggcctaga     1680

cggggaagac gtctctgcct tcctcaacat gaacatcttc cagaaggaca tcaactgtga     1740

gaggtactac agcttcatcc acttgagttt ccaggaattc tttgcagcta tgtactatat     1800

cctggacgag ggggagggcg gggcaggccc agaccaggac gtgaccaggc tgttgaccga     1860

gtacgcgttt tctgaaagga gcttcctggc actcaccagc cgcttcctgt ttggactcct     1920

gaacgaggag accaggagcc acctggagaa gagtctctgc tggaaggtct cgccgcacat     1980

caagatggac ctgttgcagt ggatccaaag caaagctcag agcgacggct ccaccctgca     2040

gcagggctcc ttggagttct tcagctgctt gtacgagatc caggaggagg agtttatcca     2100

gcaggccctg agccacttcc aggtgatcgt ggtcagcaac attgcctcca agatggagca     2160

catggtctcc tcgttctgtc tgaagcgctg caggagcgcc caggtgctgc acttgtatgg     2220

cgccacctac agcgcggacg gggaagaccg cgcgaggtgc tccgcaggag cgcacacgct     2280

gttggtgcag ctcagaccag agaggaccgt tctgctggac gcctacagtg aacatctggc     2340

agcggccctg tgcaccaatc caaacctgat agagctgtct ctgtaccgaa atgccctggg     2400

cagccggggg gtgaagctgc tctgtcaagg actcagacac cccaactgca aacttcagaa     2460

cctgaggctg aagaggtgcc gcatctccag ctcagcctgc gaggacctct ctgcagctct     2520

catagccaat aagaatttga caaggatgga tctcagtggc aacggcgttg gattcccagg     2580

catgatgctg ctttgcgagg gcctgcggca tccccagtgc aggctgcaga tgattcagtt     2640

gaggaagtgt cagctggagt ccggggcttg tcaggagatg gcttctgtgc tcggcaccaa     2700

cccacatctg gttgagttgg acctgacagg aaatgcactg gaggatttgg gcctgaggtt     2760

actatgccag ggactgaggc acccagtctg cagactacgg actttgtggc tgaagatctg     2820

ccgcctcact gctgctgcct gtgacgagct ggcctcaact ctcagtgtga accagagcct     2880

gagagagctg gacctgagcc tgaatgagct gggggacctc ggggtgctgc tgctgtgtga     2940

gggcctcagg catcccacgt gcaagctcca gaccctgcgg ttgggcatct gccggctggg     3000

ctctgccgcc tgtgagggtc tttctgtggt gctccaggcc aaccacaacc tccgggagct     3060

ggacttgagt ttcaacgacc tgggagactg gggcctgtgg ttgctggctg aggggctgca     3120

acatcccgcc tgcagactcc agaaactgtg gttatttggg atggacctga ataaaatgac     3180

ccacagtagg ttggcagcgc ttcgagtaac aaaaccttat ttggacattg gctgctgaat     3240

ggtcctatct gctggctctc ccctgagatc tggacagagg aagatgggag ggtgctcatc     3300

acccccccag cataatgatc agcctccttc ctagagacag actcatgcag attgagatca     3360

aaagtccctc tgcttgggat caaattaatg tttgacagag ctggccaggc gtggtggctc     3420

atgtatgtaa tcctagcact tcgagaggcc gaggcaggtg gatcacgagg tcaggagttt     3480

gagattagcc tggccaagat ggtgaaaccc tgtctctact aaaaataaaa aaaaattagc     3540

cagg                                                                  3544


<210> 1279
<211> 1055
<212> DNA
<213> Homo sapiens

<400> 1279
atggtcagct cctgttgtgg ttccgtctgc tctgaccagg gctgtggcct ggagacctgc       60

tgccgcccca gctgctgtca gaccacctgc tgcaggacca cctgctgccg ccccagctgc      120

tgtgtgtcca gctgctgcag accccagtgc tgccagtctg tgtgctgcca gcccacctgc      180

tgccgtccca gctgctgtcc cagctgctgt cagaccacct gctgcaggac cacctgctgc      240

cgccctagct gctgtgtatc cagctgctgc agaccccagt gctgccagtc tgtgtgctgc      300

cagcccactt gctgccgtcc cagctgcagc atctccagct gctgtcgccc cagctgctgt      360

gtgtccaggt gctgcaggtc ccagtgctgc cagtctgtgt gctgccagcc aacctgctgc      420

cgtcccagct gctgcatctc cagctgctgc cgcccctctt gctgtgaatc cagctgctgc      480

cgcccgtgct gctgccgccc ctgctgctgc ctgcgtccag tctgtggccg agtctcctgc      540

cacaccactt gctatcgccc aacctgtgtc atttccacct gcccccgtcc cttgtgctgt      600

gcctcctctt gctgctgagc tccttgcctg aaactatctc ctccccttca gctcactcct      660

cacagaagca gaccttgtgc atctcataaa caactcagaa gaggccattc ccaccaactg      720

tgtttccata tcctggacat atatctagga tatatgtcct ggctatacat ctagaatata      780

tgttccccat gttgacccaa gtgtgaaatt agatattatt tacagaaaga aattaataga      840

atttaccaaa ttttatacct tatatttgta tttatggata ccaagttctt ctgtcccaaa      900

catggaaatt cttgcagggt aactcggggc aaggttgtct cactctcaga tttgaaagtc      960

tgattgtttc accctgtatt tccttttaca gcaatgtttc tgtatcttat ttttgctgct     1020

tctgaataaa actccacttt tgtcgcatag aaata                                1055


<210> 1280
<211> 982
<212> DNA
<213> Homo sapiens

<400> 1280
cgccgctcgc cgcagactta cttccccggc tcagcaggga aaggttccta gaaggtgagc       60

gcggacggta tgcaaagttg tgaatccagt ggtgacagtg cggatgaccc tctcagtcgc      120

ggcctacgga gaaggggaca gcctcgtgtg gtggtgatcg gcgccggctt ggctggcctg      180

gctgcagcca aagcacttct tgagcagggt ttcacggatg tcactgtgct tgaggcttcc      240

agccacatcg gaggccgtgt gcagagtgtg aaacttggac acgccacctt tgagctggga      300

gccacctgga tccatggctc ccatgggaac cctatctatc atctagcaga agccaacggc      360

ctcctggaag agacaaccga tggggaacgc agcgtgggcc gcatcagcct ctattccaag      420

aatggcgtgg cctgctacct taccaaccac ggccgcagga tccccaagga cgtggttgag      480

gaattcagcg atttatacaa cgagcccatg caggtgctgt tttccggtga ggccacccac      540

cgcaagtact attccaccac ccacggtgct ctgctgtccg gccagcgtga ggctgcccgc      600

ctcattgaga tgtaccgaga cctcttccag caggggacct gagggctgtc ctcgctgctg      660

agaagagcca ctaactcgtg acctccagcc tgccccttgc tgccgtgtgc tcctgccttc      720

ctgatcctct gtagaaagga tttttatctt ctgtagagct agccgccctg actgccttca      780

gacctggccc tgtagctttt ctttttctcc aggctgggcc gtgagcaggt gggccgttga      840

gttacctctg tgctggatcc cgtgccccca cttgcctacc ctctgtcctg ccttgttatt      900

gtaagtgcct tcaatacttt gcattttggg ataataaaaa aggctccctc ccctgcccct      960

cagcttctct ctggttttct ca                                               982


<210> 1281
<211> 8131
<212> DNA
<213> Homo sapiens

<400> 1281
gataaggtgg cggcggcgaa ggcagcggca ggtcgggagc aagatggcgc tgcggccagg       60

agctggttct ggtggcggcg gggccgcggg agctggcgcg gggtccgccg ggggaggcgg      120

cttcatgttt cctgttgcag gtgggataag accccctcaa gcaggcctga tgccgatgca      180

gcaacaagga tttcctatgg tctctgtcat gcagcctaat atgcaaggca ttatgggaat      240

gaattacagc tctcagatgt cccaaggacc tattgctatg caggcaggaa taccaatggg      300

accaatgcca gcagcgggaa tgccttacct aggacaagca cccttcctgg gcatgcgtcc      360

tccaggccca cagtacactc cagacatgca gaagcagttt gccgaagagc agcagaaacg      420

atttgaacag cagcaaaaac tcttagaaga agaaagaaaa agacgccagt ttgaagagca      480

gaagcaaaag ctcagacttt tgagcagtgt gaaacccaag acaggagaga agagtagaga      540

tgatgctttg gaagccataa aaggaaattt agatgggttt tccagagatg caaaaatgca      600

ccctactcca gcatcgcacc ccaagaaacc aggcccttcc ttggaggaga agttcctagt      660

atcttgtgat ataagtacat ctgggcagga acaaattaaa ttaaatactt ctgaagttgg      720

ccacaaagcc ctaggcccag gttccagtaa gaagtatccc agtttaatgg ccagtaacgg      780

ggttgctgta gatggatgtg taagtggtac caccactgca gaggcagaaa atacttcaga      840

tcaaaacctg tcaattgaag agagtggtgt gggagtattt ccctcacagg atcctgctca      900

gcccagaatg cctccttgga tttacaatga gagtttggtt ccagatgcct ataagaaaat      960

cttagaaacc acaatgactc caactggaat agatactgcc aaactgtatc ccattctgat     1020

gtcatctggg cttcccaggg aaactcttgg acagatatgg gccttagcta atcgaactac     1080

acctggcaaa cttacaaaag aagaacttta taccgttcta gccatgatag cggtaacaca     1140

gaggggcgtt cctgcaatga gtcctgatgc tttaaaccag ttcccagcag ctcctattcc     1200

aactttaagt ggcttttcta tgactctgcc tacaccggtg agtcagccaa ctgtgatacc     1260

ttcaggtcct gcgggctcca tgcccctcag ccttggacag ccagtcatgg gcattaacct     1320

tgttggacca gtgggtggag ctgcagccca ggcttctagt ggtttcatac caacctaccc     1380

tgcaaatcag gtagtaaagc cagaagaaga tgacttccag gattttcaag atgcttctaa     1440

gtcaggatcc cttgatgact cattcagtga tttccaagag ttgcctgctt cttcaaaaac     1500

aagtaactcc cagcatggaa acagtgcccc ttctttgttg atgccacttc ctggaactaa     1560

agcattgcct tcaatggaca aatatgctgt gtttaaagga attgcagctg acaagtcctc     1620

tgaaaatact gttccacctg gagatcctgg tgataaatat agtgctttca gagaacttga     1680

acagacagca gagaataaac ctttaggaga aagctttgca gaattcagat ctgcaggaac     1740

tgatgatggt ttcaccgatt ttaaaacagc cgatagtgta tcaccactag agccaccaac     1800

aaaagacaaa acttttccac catccttccc ctcaggaact atacaacaga aacaacaaac     1860

acaagtgaaa aaccctctga acttagcaga cctagatatg ttttcctcag ttaattgcag     1920

cagcgagaaa ccattgtctt tttcagctgt gtttagcaca tcaaaatcag tttctacacc     1980

acagtcaaca ggttctgctg ctactatgac agcattggca gcaacaaaaa cttctagttt     2040

ggctgatgat tttggagaat tcagcctttt tggggaatat tctggtctag cacctgttgg     2100

ggagcaggat gactttgcag attttatggc tttcagtaat agctctattt catctgagca     2160

aaagccggat gacaaatatg atgcccttaa agaggaagcc agtcctgttc ctctaaccag     2220

caacgtgggc agcacagtga agggtggaca aaactcgact gctgcgtcta ccaagtacga     2280

tgtcttcaga caactttctc tggaagggtc tggactaggt gttgaagacc tgaaagataa     2340

cactccttca ggaaaaagtg atgatgattt tgctgacttc cactccagta aattttcttc     2400

cataaactcg gacaaatccc tgggagagaa agcagtggct ttcagacaca ccaaagaaga     2460

ctctgcatca gtgaagtcct tagatctccc ttccattggt ggcagcagtg ttggcaagga     2520

ggactctgaa gatgcactct ctgttcagtt tgacatgaaa ttggctgatg tgggaggaga     2580

tcttaagcat gtcatgtctg atagctcttt ggatttacca acagttagtg gccagcatcc     2640

tcctgctgca gatatagagg acttaaaata tgctgctttt ggaagctaca gtagcaattt     2700

tgcagtgagc acacttacaa gctatgactg gtcagacagg gatgatgcaa ctcagggcag     2760

aaaactctct ccatttgtcc tctcagcagg aagtggatcc ccctcagcca cctcaattct     2820

tcaaaagaaa gagacttcat ttggcagttc tgaaaacatc accatgacat ctctctccaa     2880

agtaacgacc tttgtaagtg aagatgctct tccagagacc accttcccag ctcttgccag     2940

ttttaaagac acgattcctc agaccagtga gcaaaaggaa tatgaaaaca gagactataa     3000

agatttcaca aaacaggacc tgcctacggc tgaacggagc caggaggcca cgtgtcccag     3060

cccagcgtcc agtggtgcct ctcaagaaac cccgaacgaa tgttcggatg actttggaga     3120

gtttcaaagt gaaaagccca aaatcagcaa atttgacttc ttagtagcca cttcacaaag     3180

caaaatgaaa tccagtgaag aaatgatcaa aagtgagctg gcaacctttg acctttctgt     3240

tcaaggatca cacaagagga gtttgagcct tggtgataaa gaaataagcc gttcttctcc     3300

ttctccagct ttggagcagc ctttcagaga ccgttccaat actctgaatg agaagcccgc     3360

cctgcccgtc atccgagaca agtacaaaga cctgacggga gaggtggagg aaaatgagag     3420

atatgcatat gaatggcaga gatgcctggg gagtgccctg aatgtcatta agaaggcaaa     3480

tgatacctta aatggaatca gtagtagttc tgtttgcaca gaagtaattc agtcagctca     3540

aggcatggaa tatttattag gtgttgttga agtgtacagg gtaaccaagc gtgtggagct     3600

ggggataaaa gccactgcag tgtgcagtga gaaactccag cagttgctga aggacatcga     3660

taaagtatgg aataacctaa tcggcttcat gtcactcgcc acactcacac cagatgaaaa     3720

ctcgctggat ttttcctcct gtatgttacg gcctgggatt aaaaatgctc aggagcttgc     3780

ctgtggagtg tgcctcttga atgtggactc gaggagccgg aaagaagaga agcctgcaga     3840

agaacatcct aaaaaagcat tcaactcaga aacagacagt ttcaagctgg cctatggagg     3900

gcaccagtat cacgccagct gtgccaactt ctggatcaac tgtgtcgaac caaagcctcc     3960

tggcctcgtc ctgcctgacc tgctctgaac aactcctctg tgaagcattg actttttttt     4020

ttctgtgaca ccccacgggg tgacagggac caataaatag aatgcgagca ctgcacagtt     4080

cgcttccctg aatcgatatg aagaacaccg caagggacgg ggcccccgtc atccccacgg     4140

ccagtctgca ggacttcagg taaaattgtc ccacccaaac tgcacgtggc accagaagct     4200

tgctcactta tctctactta agattttctg aaatacggac cacggctttc ttgatctaag     4260

gaagaacttg ctgctgcagt attgaaactg tgaagaactg acatttgaag aaaaatagat     4320

taccgttgcg ggactagaat gggcgactgc ttggagccag tgcttgtttt tatctaggac     4380

acttactgtc ctgtgaagta gaatacattt atctgcattt agtttgttaa tgtctgaaat     4440

gaataaaaag aggaaattgc gattaaactg atgttctgct ttttatggag aagattctgc     4500

ccatctcccc tggacagtag caggcaggtg agggcagatt ttacccactt ggttgtcaca     4560

actgaaccag ttctctactc cttcccttca cttctgtcca ctctcaagac tttttcccaa     4620

aacatgcctg ggcactctgc agccgtgaag aatgctcatt ttgacagagg cccaaatcct     4680

gtgtattagg ataatatcct tccccccggg agccttcgct gcaaacctgt tctgccgcat     4740

gcaaagactg tgaccatgga gttttctcag acaagatttg gaaaggcagt ggaatgaaat     4800

ctctttgcag tggcctctct ccaaatttcc aaagatgact gcatagggac caacactgcc     4860

tgactttgca gtatctgtga gaaaaacctg aaaattaatt cagggtgaaa atgtggagct     4920

ctcggcctag tgtaaagtat caagatgtat atttatggga tagatacatg acttagaaga     4980

agtagaagaa aattgtccag aaacagtact gaattttaga tagaaaaggc tcatgcttcc     5040

tggagtaggg aattgtcttt gccatttaat gtgaatgcat aaaattaggg gaaaaaccca     5100

agtggctaag agctgtgtta ttcctgggaa gaactaccaa tctagggcac acgtctctct     5160

gaattgttga ttatgcgctt tatgaagaga tttttcaatc tcgtgtgctt tactttgtgt     5220

ggtttagacc ctctgaccta gacttttatt tttaaactga aaaagttggt cttgtctata     5280

taattgctgc ttttacataa tttattttcc cctctcagga caaattctgt cttgctccat     5340

cttacagctt ttccatgttc tccaagaaag gtgtggaaca ttttcattaa acagctgttg     5400

ctgaggcttc tgcttgacct tctgcgtgcc cgaatgcaca gagaggcacc gaggagagaa     5460

aggcttttct cactcgctcc cgatgatacc gtctctggcc attcctgact gaggcagctc     5520

actctgaatg ggcacctttg gagcttttgc ccaccacaag gctagtgggg tgtttctaac     5580

aacacaagtg ggacagcttt tggcaggctt ttcctgaggc ctcggcgctt ccatcctgga     5640

cagcaccact tccacatgga gctggaatgc aagcaggctg ctaattggcc ttaaaaattc     5700

tttgtttttt tttgagatgg agtttcactc ttgttgccca ggcttgagtg caatggcaca     5760

atctcagctc agtgcaacct ccgcctcccg ggttcaagcg attctcctgc ctcagcctcg     5820

tgagtagctg ggattacagg cgtgcaccac cacgcccagc taattttgta tttttagtag     5880

aggcaaggtt tctccatgtt ggccaggctt gaactccgga cctcaggcga tccgcccgcc     5940

tcagcctccc aaagtaccgg gattacaggc gtgagccact gcgcctggcc taaatttcat     6000

aacagaacca tgacagcaga atctaccttt gcaataagaa tgtttcccag gagttagaga     6060

ccagccctgg gcatgatggt aaagacccca gctaattata caaaaaataa ttagccgggt     6120

aggtggagtg catctgtgga cattcgtggt cccagctact aggtaagctg aggcgggaga     6180

tcacaagtcc aggagtttga ggctgcacgt gacagcgtag gtgatgacag agcgagacac     6240

tgtctcttaa aaaaaaaaaa aaaaaagttt cccagtttga atttgtattg ctgaagcatt     6300

tttttgaaat gctatataga tgcctgtcat gtcacagtgg cccagtatca acattttaaa     6360

aagctcactt ggtagctggg ctggtttcta ttcctgagaa attccagaat gcctcagata     6420

aaattcctta gtataatccc cattttcctt accaaggatg gtaggcttag tcactccttg     6480

ggaggtgcca caggaaaatt cagcagatgt caacagaaaa aaagcctttg ctatgaaaag     6540

tattcactac ctttcatatc tcttgaatac ttgaaatgtt taattagatg ccaccaatag     6600

ggatccaagg agtgtgggac acggttgcgc tgcttttctt tataaacgtt tattaaaatg     6660

gctcaacgct gcattcagct tcacctcagc tcttcttgtc agccaggagc cccgtgtcct     6720

tggaaactgt agccaaggtt acttatttcc atactgtgca ttgtgtcagc ccgcttcacc     6780

ccactgcttg aatggccatt aataagcact tttctttttt tggtgggatg ttttgccttt     6840

aaaattttta tggcttagtg tgtaatttaa tttttgtctg gacatgcttg agatagaaga     6900

ggtactggat atatgaggat attttccatg ctttattttt cctgtggcta ctagttagca     6960

ttccataggg gttgtgaatt tttaattatt tgaatatttt gtgtacatat acatatttga     7020

agggttttgg gggggtctta tttgtttaaa ggtgtcttct gtttgcctat ttcaagtgta     7080

cttcagcttt gcaaagatta tagggctgta tgttacagaa ataggaaatg ctggccctgt     7140

actggggacc actacaaaaa ttccctttag ccgggcgtgg tggctcacgc ctgtaatccc     7200

cagcactttg ggaggccgag ccgggtggat cacccgaggt caggagttca agaccagcct     7260

ggccaacatg gcgagaccct gtctctacta aaaatacaaa aattagctgg gcatggtggc     7320

aggtgcctgt aatccgagct actcgggagg ctgaggcagg agaattgctt gaaccagaga     7380

ggcggaggtt gcagtgagcc gagatcgcgc cactgcactc cagcctgggc aacaagagcg     7440

aaactctgtc tcaaaaataa aaaattccct ttaacacctt caaggtcaaa tgcctgcctt     7500

tgtgaacagt taataaactg acattttcag acatttgcca ttcagaaggg agcattgtag     7560

cctgctgtag accattccag caaatgtcag aatgcagggc aagatgtgtg tcgactatgt     7620

tttttatgtt taagttactt acttatttct tcaggtaagt gtgtaccaaa taacaatact     7680

gaaaagccct ccccttgcca ggccgaggaa ataaagctta agtgaaacag ctcttggggg     7740

aaaaatgcca ctttacaaat acttttctaa caaaatagca ttataatgaa gtttttactt     7800

aattccatta tttatatgtt gacgtgaatg taagtggtta aaaagtattc atgtgggaca     7860

tctcattact ttgtagctgt ggctttatta accagtgaat gctgtggccc ttagcgaaat     7920

gcgttgtctt ctgcgtgatg tggaattcgc gcctgtattt taaaagatgg tgtggtttct     7980

cccttgtttg tattttaata aacaactgct ctaattgatg tgtttagaca ttataaagct     8040

tcacctttaa aatattttca gggtctgttc tgaaatcacc ccttgttaaa cttctctaac     8100

caaaatacaa gtgtagaaga atgtcaggct a                                    8131


<210> 1282
<211> 1398
<212> DNA
<213> Homo sapiens

<400> 1282
taatagttgc tgttgctgca cttccgcttc tctcccagcg agagagagac acgagtggcc       60

aggcccagcc gcagccgcag cagcagccgc cgcggcggca cggaggagcc agacacaaag      120

agaggggctg tttgcggggt ggggtggggg gttcgctatg tcggatgacg attcgagggc      180

cagcaccagc tcctcctcat cttcgtcttc caaccagcaa accgagaaag aaacaaacac      240

ccccaagaag aaggagagta aagtcagcat gagcaaaaac tccaaactcc tctccaccag      300

cgccaagagt gctggtccca aaggcgataa catctatgaa tggagatcaa ccattctagg      360

gcctccagga tccgtgtatg agggtggtgt attctttctc gatatcactt ttacaccaga      420

atatcccttc aagcctccaa aggttacatt tcggacaaga atctatcatt gtaatattaa      480

cagtcaaggt gttatttgct tggacatatt gaaagataat tggagtccag cactaaccat      540

ttctaaagtc ctcctttcta tctgctcact tcttacagac tgtaatcctg ccgacccctt      600

ggtgggaagt attgccactc agtatatgac caacagagca gaacatgaca gaatggccag      660

acagtggacc aagagatacg ctacataaat tggggtttca caattcttac attatttgtc      720

tgtcacagaa gagagctgct tatgattttg aaggggtcag ggagggtggg agttggtaaa      780

gagtagggta tttctataac agatattatt cagtcttatt tcctaagatt ttgttgtaac      840

ttaaggtatc ttgctacagt agacagaatt ggtaatagca acttttaaaa ttgtcattag      900

ttctgcaata ttagctgaaa tgtagtacag aaaagaatgt acatttagac atttgggttc      960

agttgcttgt agtctgtaaa tttaaaacag cttaatttgg tacaggttac acatatggcc     1020

atttatgtaa agtccctcta agactacata ctttttgttt aaaacaaaat tggaatttgt     1080

tttcccttct tggaagggaa cattgatatt taacagagtt tttagagatt gtcatctcat     1140

atatataaaa tggacacgtg gctataaaac accatataag agatgagtag tgcgttttat     1200

tttatatgcc aatctacttt gtttaaaaaa ggtctgaatc aggacttgtg aaaacctgta     1260

gtgaaatacc ttaagctgtt aactaactgt aaggcgtgga ataggagttg ctcagtggat     1320

tggttctatg ttgtggacta cttaagtctg catttgttac tgtgctaata aacaatatta     1380

aaaaccacct aataaaca                                                   1398


<210> 1283
<211> 9573
<212> DNA
<213> Homo sapiens

<400> 1283
aagcaatcga aagaagatgg ccgctcccac gattgtgggg gaggtctcca ctggggaggg       60

gcagaggaaa ttcggtcgaa aaagagataa agctgaagga aataaaattg gcacggagtc      120

tgggaaagta gtttccctaa aggagtctta gaaatagggt tggtctggaa cctaaggggc      180

ggagccgacg cgtagagccg ctttgcgcgt gcgcatcacc taggcggtta gatttgaata      240

cttcactgag gcgagccggg cgttgtgagc ggactgctag aggcggctgt ctgtttccgc      300

tctaaggaaa ctcagagcgt gtggacccca aacaagtctg cgcaaaattt gtcgaggagg      360

tttgccgcgg cagaaaagtt ttcttcaaaa atggatgggg tgtcttcaga ggctaatgaa      420

gaaaatgaca atatagagag acctgttaga agacggcatt cttcaatatt gaaaccccca      480

aggagtcctc ttcaggacct cagaggtggg aatgaaagag ttcaggaatc caatgctttg      540

agaaataaga aaaactctcg tcgagtcagc tttgcagata ctataaaggt attccagacg      600

gagtctcata tgaaaatagt gagaaagtca gaaatggaag gctgcagtgc aatggtgcca      660

tctcagctgc aacttctgcc tcctgggttt aagcgattct cctgcctcag cctcccagaa      720

acagaaacag gagaaaatct tcttttgata cagaataaga aattagaaga taattactgt      780

gaaattactg ggatgaacac attgctttct gctcccattc atacccagat gcaacagaag      840

gagttttcaa ttatagaaca tacccgtgaa aggaaacatg caaatgacca gacagtcatt      900

ttttcagatg aaaaccagat ggacctgaca tcaagtcaca ctgtaatgat taccaaaggc      960

cttttagata atcccataag tgaaaagtcc accaagatag ataccacatc atttctagct     1020

aatttaaagc ttcacaccga ggactcaaga atgaaaaaag aagtaaattt ttccgtggat     1080

caaaacactt cttcagaaaa taaaatagat ttcaatgact tcataaaaag attgaaaaca     1140

ggaaaatgta gtgcttttcc tgatgtgcct gataaagaaa attttgagat acctatttat     1200

tccaaggaac cgaacagtgc ctcttctaca catcaaatgc atgtatctct taaggaagat     1260

gaaaataaca gtaatattac taggctcttt agagaaaaag atgatgggat gaatttcacc     1320

cagtgtcata cagccaatat tcagacattg attcccacat ccagtgagac caactcacgg     1380

gaatctaaag gtaatgatat tacaatttat ggcaatgact ttatggactt gacatttaac     1440

cacactttgc agatcttacc tgcaacaggt aatttttctg aaatagaaaa tcaaactcag     1500

aatgccatgg atgtaacaac aggttatgga actaaagctt caggaaataa aacagttttt     1560

aagagtaaac aaaatactgc ttttcaagac ctttccataa actctgcaga caaaatacat     1620

attaccagaa gtcatattat gggggcagaa actcacatag tctcacagac ttgtaatcag     1680

gatgccagaa tattagccat gaccccagaa tctatatatt ctaatccatc tattcaaggt     1740

tgtaagactg ttttctattc tagttgtaat gatgccatgg aaatgaccaa atgtctctca     1800

aatatgagag aggagaaaaa tttgctaaag catgacagta attatgctaa aatgtattgc     1860

aatccagatg ctatgtcttc tctcacagag aaaactattt attccggaga ggagaacatg     1920

gacattacca agagtcatac agttgcaata gataatcaaa tttttaaaca agatcaatca     1980

aatgtgcaaa tagcagctgc accaacaccc gaaaaagaaa tgatgctcca aaatcttatg     2040

accacatcag aagatgggaa aatgaatgta aattgtaact cagttcctca tgtatctaag     2100

gaaagaatac agcagagcct gtcaaatcct ttgtctattt cattgactga tagaaagact     2160

gaactcttat caggtgaaaa tatggatttg actgaaagtc acacaagtaa cttaggaagt     2220

caggttcctc ttgcagctta taatctagca ccggagagta ccagtgaatc tcactctcag     2280

agcaaaagct cttcagatga atgtgaagaa attaccaaaa gtcgtaatga accatttcag     2340

cgatcagaca taatagccaa aaacagctta accgacacct ggaacaaaga caaagattgg     2400

gttttgaaga ttttgcccta ccttgataaa gattctcctc agtcagctga ttgtaatcag     2460

gagatagcaa caagccataa tatagtctac tgtggtggag ttcttgataa acaaataact     2520

aatagaaata cagtatcatg ggaacaatct ttgttttcta ccacaaagcc attattttca     2580

tcaggacagt tctctatgaa aaatcatgat actgctataa gtagtcatac agtgaaatct     2640

gtactaggcc agaattctaa actggctgag ccactgagga aaagtttaag caatcccaca     2700

cctgactatt gccatgacaa gatgattata tgttcagagg aagagcaaaa tatggatcta     2760

acaaagagcc acactgtcgt cattggattt ggtccttctg aactacaaga acttggtaaa     2820

actaatttag aacacactac tggccagcta acaacaatga acagacagat agctgtaaaa     2880

gttgaaaaat gtggtaaaag tcccatagaa aaaagtggag tgcttaaatc taactgtatt     2940

atggatgtgt tagaggacga aagtgtacag aaacctaaat ttccaaagga aaagcaaaat     3000

gtcaaaattt ggggaaggaa aagtgttggt ggaccaaaaa ttgataagac tattgtattt     3060

tcagaagacg ataagaatga tatggatatc actaagagtt atacaataga aataaaccat     3120

agacctttat tagagaaacg tgattgtcat ttggtgccat tggcaggaac ttctgaaact     3180

attttatata catgtaggca ggatgacatg gagatcacta gaagtcacac aactgcctta     3240

gaatgtaaaa ctgtctcacc agatgaaata actactaggc ctatggacaa aactgtagtg     3300

tttgtagata atcatgttga actagaaatg acagagtccc atactgtttt cattgactac     3360

caagaaaagg aaagaacaga cagacctaac tttgaactat cccaaaggaa aagcctagga     3420

acaccaacag tgatatgtac tcctactgag gagagtgttt tctttccagg aaatggtgaa     3480

agtgaccgtc tagtagcaaa tgacagccag ctaacccctc tggaggaatg gtctaataat     3540

aggggccctg tagaggtagc tgataacatg gaattgtcta aatcagccac ttgcaaaaac     3600

atcaaagatg tacaaagtcc tggatttctg aatgaacctc tatcaagcaa aagtcagaga     3660

agaaaaagcc ttaagctaaa aaatgacaag accattgtat tttcagagaa tcataaaaat     3720

gatatggata ttacccagag ttgtatggtg gaaatagata acgaaagtgc cctggaggat     3780

aaagaggact tccatttggc aggggcttct aaaactattt tgtattcatg tgggcaggat     3840

gacatggaga tcactaggag tcacacaact gccttagaat gtaaaactct cctgccaaat     3900

gaaatagcta ttaggcccat ggacaaaacc gtattgttca cagataatta cagtgatctg     3960

gaagtcaccg attcccatac tgttttcatt gactgtcaag ccacagagaa aatacttgaa     4020

gaaaacccta aatttggaat aggaaaagga aaaaacttgg gtgtttcctt tcctaaggat     4080

aatagctgtg ttcaagaaat cgctgaaaaa caagcactgg ctgtaggaaa caaaatagtt     4140

cttcacaccg agcaaaagca acaactcttt gctgctacta atagaactac taatgaaatc     4200

atcaaatttc atagtgctgc tatggatgaa aaggtcatag ggaaagttgt agaccaggcc     4260

tgtacattgg aaaaagcgca agttgaaagc tgtcagttaa ataatagaga tagaagaaat     4320

gtggacttta caagtagtca tgcaactgct gtttgtggat ccagtgataa ttattcctgt     4380

ttaccaaatg ttatttcctg tactgataat ttggagggta gtgccatgct cttatgtgat     4440

aaagatgagg aaaaagccaa ttattgccca gtgcaaaatg atcttgctta tgcaaatgat     4500

tttgccagtg aatattactt ggaatctgag ggacagcctc tctctgctcc ttgtcctttg     4560

ttagagaagg aagaagttat tcaaaccagt accaaaggac agttagactg tgttataaca     4620

ctgcacaaag atcaagatct gattaaggat ccacgaaatc tattggctaa tcaaacttta     4680

gtatatagtc aagatctggg ggagatgact aaacttaatt caaagcgagt atcttttaag     4740

cttccaaagg atcaaatgaa agtctatgtt gatgacattt atgttattcc tcagcctcat     4800

ttctcaaccg accaacctcc attacctaaa aaaggacaga gtagtatcaa taaagaagaa     4860

gtaatactgt ctaaagctgg aaataagagt ttaaatatta tagaaaattc ctctgcaccc     4920

atatgtgaaa acaagcccaa aatactcaat agtgaggaat ggtttgctgc agcctgtaaa     4980

aaagaactga aggaaaatat tcaaacaact aactataata cagctctaga tttccacagt     5040

aactcagacg taactaagca agtcattcaa actcatgtca atgctggaga agcaccagat     5100

cctgtaatta catctaatgt tccatgtttt catagtatca aaccaaatct gaataatttg     5160

aatggaaaaa ctggagagtt tttagccttt caaactgttc atctaccacc ccttccagag     5220

caattacttg aattaggaaa taaggcacac aatgatatgc atatagtgca agctacagaa     5280

atacataata ttaacataat ctccagcaat gctaaagata gtagagatga ggaaaataaa     5340

aagtctcata atggagctga aaccacctct ctaccgccaa agacagtttt taaagataaa     5400

gtaaggagat gttctttggg aatctttttg cctagattgc ccaacaagag aaattgtagt     5460

gtcactggta ttgatgacct ggaacagatt ccagcagaca caactgatat aaatcactta     5520

gaaactcagc cggtctctag caaagattca ggcattggat ctgttgcagg taaactgaac     5580

ctaagtcctt ctcaatatat aaatgaggaa aatcttcctg tatatcctga tgagatcaat     5640

tcttcagact ctattaacat agaaactgag gaaaaggcct tgattgagac ataccaaaaa     5700

gagatttcac catatgaaaa taaaatggga aaaacttgca atagccaaaa aagaacgtgg     5760

gtacaagaag aagaagatat tcataaggag aaaaaaatca gaaaaaatga gattaagttt     5820

agtgatacga cacaagatcg ggagattttt gatcaccata ctgaagagga tatagataaa     5880

agtgctaaca gtgtattgat aaaaaacctg agcaggaccc catctagttg cagcagctct     5940

ctggattcaa tcaaggctga tgggacctct ctggacttca gcacttaccg cagtagtcaa     6000

atggaatcac agtttctcag agatactatt tgtgaagaga gcttgaggga gaaactccaa     6060

gatgggagaa taacaataag ggagttcttt atacttctcc aggtccacat cttgatacag     6120

aaaccccgac agagcaatct cccaggcaat tttactgtaa acacaccacc tactccagaa     6180

gacctgatgt taagtcaata tgtttaccga cccaagatac agatttatag agaagattgt     6240

gaggctcgtc gccaaaagat tgaagaatta aagctttctg catcgaacca agataagctg     6300

ttggttgata taaataagaa cctgtgggaa aaaatgagac actgctctga caaagagctg     6360

aaggcctttg gaatttatct taacaaaata aagtcatgtt ttaccaagat gactaaagtc     6420

ttcactcacc aaggaaaagt ggctctgtat ggcaagctgg tgcagtcagc tcagaatgag     6480

agggagaaac ttcaaataaa gatagatgag atggataaaa tacttaagaa gatcgataac     6540

tgcctcactg agatggaaac agaaactaag aatttggagg atgaagagaa aaacaatcct     6600

gtggaagaat gggattctga aatgagagct gcagaaaaag aattggaaca gctgaaaact     6660

gaagaagagg agcttcaaag aaatctctta gaactggagg tacaaaaaga gcagaccctt     6720

gctcaaatag actttatgca aaaacaaaga aatagaactg aagagctact ggatcagttg     6780

agcttgtctg agtgggatgt cgttgagtgg agtgatgatc aagctgtatt cacctttgtt     6840

tatgacacga tacaactcac catcaccttt gaagagtcag ttgttggttt ccctttcctg     6900

gacaagcgtt ataggaagat tgttgatgtc aattttcaat ctctgttaga tgaggatcaa     6960

gctcctcctt cctccctttt agttcataag cttattttcc agtacgttga agaaaaggaa     7020

tcctggaaga agacatgtac aacccagcat cagttaccca agatgcttga agaattctca     7080

ctggtagtgc accattgcag actccttgga gaggagattg agtatttaaa gagatgggga     7140

ccaaattata acctaatgaa catagatatt aataataatg aattgagact tttattctct     7200

agctccgcag catttgcaaa gtttgaaata actttgtttc tctcagccta ttatccatct     7260

gtaccattac cttccaccat tcagaatcac gttgggaaca ctagccaaga tgatattgct     7320

accattctat ctaaagtgcc actggagaac aactacctga agaatgtagt caagcaaatt     7380

taccaagatc tgtttcagga ctgccatttc taccactaga cccttggacc accattggaa     7440

caaccaagca gaatgtactt gatattattt cagggtccca ttgctgttca gcctttgttt     7500

ttacgtcatt acaagctgag taaaattcct tctgatgatg ttatagttaa tctgtatgtt     7560

ttttatatct ctgcagaatg atggtgatga agtctggatg gtaggcctca tagcctacta     7620

tcaacttact catctttgta ccaaaggttt aagtaatagg acacttagga aaaatgtctc     7680

ctaactaaac tagtgctttc tgctttagta caagccctaa ggattaactt aagtataaga     7740

agtgttatca ctgacaagaa cattagccat tttcccataa ctagatagag ctatgatttt     7800

ttaggttgcc tggcttctgc ctagcagata tttctggagt agaaatgtat ctgtctacaa     7860

actattatcc tttttctccg ttactaaaat gctattaaga gaaagtaggg ctgggtgcgg     7920

tggctcacac ctgtaatacc agcagtttgg gaggccaaaa tgggtgaata gcctgagtcc     7980

aggaattcaa gaccagcctg ggcaacatgg caaaacccca cctctacaaa aaatacgaaa     8040

gttagccagt catggtggct tgcgcctgtg gtcccagcta cttaggagct taaggcagga     8100

ggatcacttg agcccaggag gcagaggttg cagtaagccg agaccattcc actgcactcc     8160

agcctaggca acagagcaag accctgtctc aaaaaaacaa aaagagagaa agcaatagca     8220

ctcagctatt gaaatggttg ccatcttttt ttgaaggcct tgctttttat tctatggtgt     8280

ctattatgtt ttctttttct ttttttttga gacggagtct tgctctgtcg cccaggctgg     8340

agtgcagtgg catgatctca gctcactgca agctccgcct cctgggttca cgccattctc     8400

ctgcctcagc ctcccgagta gctgggacta caggtgccca ccaccatgcc gggctaattt     8460

tttgtctttt tagtagaaat ggggtttcac gatgttagcc aggatggtct cgatctcctg     8520

acctcgtgat ccgcctgcct cggcttcaaa gtgctgggat tacaggtgtg agccaccaca     8580

cccagcaatg ttttcttaat aagtatagtt tttctaggga aagttaattc atttttgtct     8640

agtacatata tgtaaatata ttaatgttgt ttttgtgttt gtgatgtagt aaggagatgt     8700

acatagaaat tcattgaggt atatagatac tcatctgtct aggcagttcc caattttctg     8760

aagaatgttt tacagcaaaa ttttctattt tcttttatta aatagtgaca cgtcaaacaa     8820

tgtcacatcc aaaacactag tttcatcaat ttctagcagt aataatagac ttgctgtaag     8880

tattgttttc tgatgccata cccttgtcat acatattatt aaatgaccaa tattatgtat     8940

gaagtagaca aaaaaattta ctcaaacttc attcaaatcc taattgtgat aatttttgtt     9000

ttatatttaa ttataaacca aaatacattt gcatttttaa gctaatttgt ctcaaaattt     9060

tgctttatat ttttggatca ggttaaagtc ctgtggatcc cctgaatgtt attgtccctc     9120

ttgattggtt tttacttctg agctatacgt caaaagacac ataagcttca aaagtcaaga     9180

caaacctcat ttgccataaa aatcaagata tagatgttct gttccgtaaa ctccttgaaa     9240

aacattttaa agtcatcaat atgatctgtt tcccatgaaa cttaagttag ctttcttatt     9300

ggagttattt cttttctgta agtctgaaaa gtagagattt tgttttacgc attttagtaa     9360

cctgcaacaa ccaactctaa aaaagatttg gcttgtaatg acggtctctg cttttttggg     9420

tttggagtac acaattgtaa tatttactta gttatttgtg tttttctttg ttcaaggtat     9480

tgactagttt cataaatttt ttgaaagttt ttctttcatt ggttggaaag cagattacat     9540

tttgcactat taaaataagt ttattacttt aaa                                  9573


<210> 1284
<211> 5218
<212> DNA
<213> Homo sapiens

<400> 1284
cccatctcta cgaaaaatac aaaaattagc caagtatggt ggccggcgcc tgtaatccca       60

gctactcggg agactgaggc agagaactgc ttgaacctgg gaggcagagg ttgcagtgat      120

ccgagatcgc gtcactgcac tccagcgtgg gcgacagagc gagactccgt ttcagaaaag      180

aaaaaaaaaa aaaaaaaaaa gggagtcggg gtggagctct cattggctcg ttgcatgtga      240

gtgtccctac ggcctagaaa tacaagagaa gcacatcgga acgggctgga aatccaccca      300

gttaactaga gggctttgaa ccttttatta acttggaggt tgactctcct gtcaactcga      360

ttcccttttg gctgtttggc agggtcagtg agacatcccc tgggtcgctc gaccccgtag      420

gacggttcag ggagccctcc aggtcttcgt ttctcctctt ccccgcacag tgctgttatc      480

cagctggggg atccaacgca cacttaaggc tccagcaaag tggctccgct gccggatggg      540

agtgccccag tgtgctggat gaagctggcg catgcaccat gtcatcatgt gtctctagcc      600

agcccagcag caaccgggcc gccccccagg atgagctggg gggcaggggc agcagcagca      660

gcgaaagcca gaagccctgt gaggccctgc ggggcctctc atccttgagc atccacctgg      720

gcatggagtc cttcattgtg gtcaccgagt gtgagccggg ctgtgctgtg gacctcggct      780

tggcgcggga ccggcccctg gaggccgatg gccaagaggt cccccttgac acctccgggt      840

cccaggcccg gccccacctc tccggtcgca agctgtctct gcaagagcgg tcccagggtg      900

ggctggcagc cggtggcagc ctggacatga acggacgctg catctgcccg tccctgccct      960

actcacccgt cagctccccg cagtcctcgc ctcggctgcc ccggcggccg acagtggagt     1020

ctcaccacgt ctccatcacg ggtatgcagg actgtgtgca gctgaatcag tataccctga     1080

aggatgaaat tggaaagggc tcctatggtg tcgtcaagtt ggcctacaat gaaaatgaca     1140

atacctacta tgcaatgaag gtgctgtcca aaaagaagct gatccggcag gccggctttc     1200

cacgtcgccc tccaccccga ggcacccggc cagctcctgg aggctgcatc cagcccaggg     1260

gccccattga gcaggtgtac caggaaattg ccatcctcaa gaagctggac caccccaatg     1320

tggtgaagct ggtggaggtc ctggatgacc ccaatgagga ccatctgtac atggtgttcg     1380

aactggtcaa ccaagggccc gtgatggaag tgcccaccct caaaccactc tctgaagacc     1440

aggcccgttt ctacttccag gatctgatca aaggcatcga gtacttacac taccagaaga     1500

tcatccaccg tgacatcaaa ccttccaacc tcctggtcgg agaagatggg cacatcaaga     1560

tcgctgactt tggtgtgagc aatgaattca agggcagtga cgcgctcctc tccaacaccg     1620

tgggcacgcc cgccttcatg gcacccgagt cgctctctga gacccgcaag atcttctctg     1680

ggaaggcctt ggatgtttgg gccatgggtg tgacactata ctgctttgtc tttggccagt     1740

gcccattcat ggacgagcgg atcatgtgtt tacacagtaa gatcaagagt caggccctgg     1800

aatttccaga ccagcccgac atagctgagg acttgaagga cctgatcacc cgtatgctgg     1860

acaagaaccc cgagtcgagg atcgtggtgc cggaaatcaa gatcctggtg aagaccatga     1920

tacgtaaacg ctcctttggg aacccattcg agggcagccg gcgggaggaa cgctcactgt     1980

cagcgcctgg aaacttgctc accaaaaaac caaccaggga atgtgagtcc ctgtctgagc     2040

tcaaggaagc aaggcagcga agacaacctc cagggcaccg acccgccccc cgtgggggag     2100

gaggaagtgc tcttgtgaga ggcagtccct gcgtggaaag ttgctgggcc cccgcccccg     2160

gctcccccgc acgcatgcat ccactgcggc cggaggaggc catggagccc gagtagctgc     2220

ctggatcgct cgacctcgca tgcgcgccgc gtcgcctctg gggggctgct gcaccgcgtt     2280

tccatagcag catgtcctac ggaaacccag cacgtgtgta gagcctcgat cgtcatctct     2340

ggttatttgt tttttccttt gttgttttaa aggggacaaa aaaaaaaaaa ggacttgact     2400

ccatgacgtc gaccgtggcc gctggctggc tggacaggcg ggtgtgagga gttgcagacc     2460

caaacccacg tgcattttgg gacaattgct ttttaaaacg tttttatgcc aaaaatcctt     2520

cattgtgatt ttcagaacca cgtcagatat accaagtgac tgtgtgtggg gtttgacaac     2580

tgtggaaagg cgagcagaaa actccggcgg tctgaggcca tggaggtggt tgctgcattt     2640

gagagggagt agggggctag atgtggctcc tagtgcaaac cggaaaccat ggcaccttcc     2700

agagccgtgg tctcaaggag tcagagcagg gctggccctc agtagctgca gggagctttg     2760

atgcaactta tttgtaagaa ggatttttaa attttttatg ggtagaattg tagtcaggaa     2820

aacagaaagg gcttgaaatt taataagtgc tgctggaagg ggattttcca agcctggaag     2880

ggtattcagc agctgtggtg gggaaacatt tctcctgaaa gactgaacgt gtttcttcat     2940

gacagctgct caaagcaggt ttctgagata gctgaccgag ctctggtaaa tctctttgtc     3000

aaattacgaa aacttcaggg tgaaatccta tgcttccatg tacattacat ggcttaagat     3060

taaacaaaaa catttttcaa gtctctaact agagtgaact ctagagcaca gtagttcaga     3120

aactatttag agcttccagg atatatttca cagcttcagg catgtgatca gttagagccg     3180

atgaaaccta tgcccgcctg tatatatatt agcagcttag ctagttcata acctgtatat     3240

tctaaagact gctaaggttt tgttttcatt ttaaatccta gctgattgtt gtggtcaatg     3300

aaatacccag tttctggagg gccaggtggg aaatgctttc actggaccaa cacacaaatg     3360

atcatcctga ggatctgagc ttccctagac tccacacaat aaccttgggg caccctttta     3420

gagaagactg ttgaaaccca cagcactcgt tggggtatga ggaaaccagg gcttggcaca     3480

ggaagttccc ctttgtagct aaaagtccag aaagaaaggg ttcatctttt tgacttccaa     3540

ctgatattgg gaagtttggt tgaggttcaa gtgtgactcc ttccagagcc acaggtaggg     3600

gagtgtgaag ttgaggggga ggaaagctgg aaggactctg ccttgggaga ttcccagctc     3660

tgctttccag cgcttggtgg aatctgggct ggggaaagac ggcaccggga aactctgctt     3720

ccccattgtt tccatctgat cagctgtggt gtgaggactt ctcagacaaa ggcaaggcct     3780

cgtgcccctg cccagcccat tcatggagcc ctgggccttc ttggcttcca tagatcctaa     3840

gctcttgact gtagtttagc cagacttgtt ttgctatctt ataagcagtt cagaattagg     3900

gaatgctggt tttgaagagc aaaggacagg tagtctagag agggtcgtct ggcctgcttg     3960

ctgggtcttt gtaacccagc acttcctctt gccctcctgg ctttatgttt atggggagag     4020

gactcaatag ctccacccct tctggcacca gatggggctt ggttagtttg caataagcac     4080

cttgcagagg ttaaagccag cgggtcccta gtcttaggcc cagcctgctt gtgtgggctc     4140

tggcctggcc tggtggctgg cccagggggc agcagtgctt agagcttctg cagggcttct     4200

cttgtttaca cagctgcatc agacaatgcc atttctcccc accacggaac cttccatcta     4260

agatttcttc cagggaatgc cagcaatcag gcagcaccca gctgtggggg cagtggggtg     4320

ggggagaccc acattgatga cttttttttt ttcttttaat gaagaaacac caaagaaagc     4380

tgtggaaagg acctgcccca catgaaaagg ataagccaag atggctgtaa acacagagca     4440

tttgagctgc cactcttgga gcacattgat ttttcaaaag ccagctctgt caggaaagga     4500

ggtgctgtta tgagcagctc ttccagtggg caaagaggac gcccataatt tcttccattg     4560

ctagctcatc tgtgggacca atttggtgta agcaacctgt ggcctgcact tgtggcctcg     4620

aaggaagcac aaaccctcca tccacttccc atttcctctg cccttttcca cctccccctt     4680

ccatcccacc agctgccagt ggctcccaga aagccttatt gagccccttg ttgacacttg     4740

gggctgcgga ggcctctccc tactggtctg gcctttcctg agaggcaggt cttccgtcct     4800

cagagccttt ctggaacaag gagaatgcct gtgcaggtgg acacacaggc ctggcctgtc     4860

gctctcactt gtcttccagc ggggagcttc acgttgccga gtggaagaac catgacctcc     4920

acttgcttcc aaggtgctag ggaagtttca gggtacgctg gttcccctct ccagctggag     4980

gccgagtttc tggggactgc agatttttct actctgtgat cgattcaatg cccgatgctt     5040

ctgtttcatt cccgaccctt tctactatgc attttccttt tatcaggtgt ataaagttaa     5100

atactgtgta tttatcacta aaaagtacat gaacttaaga gacaactaag cctttcgtgt     5160

ttttccacag gtgtttaagc ttctctgtac agttgaaata aacagacagc aaaatggt       5218


<210> 1285
<211> 550
<212> DNA
<213> Homo sapiens

<400> 1285
gggctggcgg ccggggagct gcgtagctcc cggccccgcg gccatgccca agcggagctg       60

ccccttcgcg gacgtggccc cgctacagct caaggtccgc gtgagccaga gggagttgag      120

ccgcggcgtg tgcgccgagc gctactcgca ggaggtcttc gacccatctg gggtagcgtc      180

cattgcctgt tcctcatgcg tgcgagccgt ggatgggaag gcggtctgcg gtcagtgtga      240

gcgagccctg tgcgggcagt gtgtgcgcac ctgctggggc tgcggctccg tggcctgtac      300

cctgtgtggc ctcgtggact gcagtgacat gtacgagaaa gtgctgtgca ccagctgtgc      360

catgttcgag acctgaggct ggctcaagcc ggctgccttc accgggagcc acgccgtgca      420

tggcagcctt ccctggacga gcgctcggtg ttcacactga actgtggggt cgacgggagg      480

ggtgcctttt acatgttcta ttttgtatcc taatgacaga atgaataaac ctctttatat      540

ttgcacaaga                                                             550


<210> 1286
<211> 2524
<212> DNA
<213> Homo sapiens

<400> 1286
gaagaggagg tggagaaggc ttgggctcgc gccgctgaag aaaaggaagc aaatgagctg       60

atggaagatc tgtttgaaac tttccaagat gagatgggat tctccaacat ggaagatgat      120

ggcccagaag aggaggagcg tgtggctgag cctcaagcta actttaacac ccctcaagct      180

ctacggtttg aggaactact ggccaaccta ctaaatgaac aacatcagat agcgaaggaa      240

ctatttgaac agctgaagat gaagaaacct tcagccaaac agcagaagga ggtagagaag      300

gttaaacccc agtgtaagga agttcatcag accctgattc tggacccagc acaaaggaag      360

agactccagc agcagatgca gcagcatgtt cagctcttga cacaaatcca ccttcttgcc      420

acctgcaacc ccaatctcaa tccggaggcc agtagcacca ggatatgtct taaagagctg      480

ggaacctttg ctcaaagctc catcgccctt caccatcagt acaaccccaa gtttcagacc      540

ctgttccaac cctgtaactt gatgggagct atgcagctga ttgaagactt cagcacacat      600

gtcagcattg actgcagccc tcataaaact gtcaagaaga ctgccaatga atttccctgt      660

ttgccaaagc aagtggcttg gatcctggcc acaagcaagg ttttcatgta tccagagtta      720

cttccagtgt gttccctgaa ggcaaagaat ccccaggata agatcctctt caccaaggct      780

gaggacaatt tgttagcttt aggactgaag cattttgaag ggactgagtt tcttaaccct      840

ctaatcagca agtaccttct aacctgcaag actgcccgcc aactgacagt gagaatcaag      900

aacctcaaca tgaacagagc tcctgacaac atcattaaat tttataagaa gaccaaacag      960

ctgccagtcc taggaaaatg ctgtgaagag atccagccac atcagtggaa gccacctata     1020

gagagagaag aacaccggct cccattctgg ttaaaggcca gtctgccatc catccaggaa     1080

gaactgcggc acatggctga tggtgctaga gaggtaggaa atatgactgg aaccactgag     1140

atcaactcag atcaaggcct agaaaaagac aactcagagt tggggagtga aactcggtac     1200

ccactgctat tgcctaaggg tgtagtcctg aaactgaagc cagttgccga ccgtttcccc     1260

aagaaggctt ggagacagaa gcgttcatca gtcctgaaac ccctccttat ccaacccagc     1320

ccctctctcc agcccagctt caaccctggg aaaacaccag cccaatcaac tcattcagaa     1380

gcccctccga gcaaaatggt gctccggatt cctcacccaa tacagccagc cactgtttta     1440

cagacagttc caggtgtccc tccactgggg gtcagtggag gtgagagttt tgagtctcct     1500

gcagcactgc ctgctatgcc ccctgaggcc aggacaagct tccctctgtc tgagtcccag     1560

actttgctct cttctgcccc tgtgcccaag gtaatgatgc cctcccctgc ctcttccatg     1620

tttcgaaagc catatgtgag acggagaccc tcaaaaagaa ggggagccag ggcctttcgc     1680

tgtatcaaac ctgcccctgt tatccaccct gcatctgtta tcttcactgt tcctgctacc     1740

actgtgaaga ttgtgagcct tggcggtggc tgtaacatga tccagcctgt caatgcggct     1800

gtggcccaga gtccccagac tattcccatc gccaccctct tggttaaccc tacttccttc     1860

ccctgtccat tgaaccagcc ccttgtggcc tcctctgtct cacccttaat tgtttctggc     1920

aattctgtga atcttcctat accatccacc cctgaagata aggcccacat gaatgtggac     1980

attgcttgtg ctgtggctga tggggaaaat gcctttcagg gcctagaacc caaattagag     2040

ccccaggaac tatctcctct ctctgctact gttttcccca aagtggaaca tagcccaggg     2100

cctccaccag tcgataaaca gtgccaagaa ggattgtcag agaacagtgc ctatcgctgg     2160

accgttgtga aaacagagga gggaaggcaa gctctggagc cgctccctca gggcatccag     2220

gagtctctaa acaactcttc ccctggggat ttagaggaag ttgtcaagat ggaacctgaa     2280

gatgctacag aggaaatcag tggatttctt tgagctagga gaataagagt ctggagactg     2340

ggagccttca cttcggcctc cgattggtgg cgcatagggt gtaaccaata ggaaacccct     2400

aaagggtact taaaccccag attttgcaac tggggctctt gagcagcttg ctttagcctg     2460

ctcccactct gtggaatata cttttgcttc aataaatctg tgcttttatt gcttcattgt     2520

ttca                                                                  2524


<210> 1287
<211> 7068
<212> DNA
<213> Homo sapiens

<400> 1287
tgttaggaaa gaaaaaaaaa ttcctgatgt ctggtccaag caggaattcc ccggtggatt       60

ggggaatgtc tggcttttcc tcagcttatt gatctctgtg gtaaccactg gaggccccca      120

gaagacccat agaaatgaga ggcctgaggt ctacaagtcg ctgctagaaa tattttagcc      180

tctccaaagc ccagaatgca gccccgaccc aagtttgtaa gggttctggg tgcacgctga      240

ccctgcgcgg gcagacgcgc cctttgctcc aggtccggac ctgggcgctg ctatagcaac      300

gtcctggacg cccagacctt aggccgccgc cgccgcggaa gcgaggaacc cggccttctc      360

ccgctcctga gggctgtggc ggcggcggcc cgggaggcgg cccaggctgg gtaaagaccg      420

cccggctcct cctatgcaag ctgaggcagc ggattggttt tcaagcatgc ccttccagaa      480

gcatgtctac tacccgctcg ccagcggccc agaggggccc gacgtcgctg tggccgccgc      540

cgccgcgggt gcggcctcca tggcctgtgc gccccccagc gcggcttcgg ggcccctgcc      600

cttcttccag ttcaggccgc ggctggagag tgtggactgg cggcggctga gcgccatcga      660

cgtggacaag gtggcggggg ctgtggacgt gctgacgctg caggagaaca tcatgaacat      720

caccttctgc aagctggaag acgagaagtg cccacactgc cagtcggggg tggacccggt      780

gctgctgaag ctcatccgtc tggcgcagtt caccatcgag tacttgctgc actcacaaga      840

gttcctcacc tcgcagctgc acaccctgga ggagcggctg cgcctgagcc actgcgacgg      900

cgagcagagc aagaagctgc tcaccaagca ggcgggggag atcaagacgc tcaaggaaga      960

gtgcaaacgc cggaagaaga tgatctccac ccagcagctg atgatcgagg ccaaagccaa     1020

ctattaccag tgccattttt gtgacaaggc ctttatgaac caagcttttc tacaaagtca     1080

cattcaacgc cgccacactg aagaaaattc tcattttgag tatcagaaaa atgcacagat     1140

tgagaagctc cggagtgaga tcgtcgtatt gaaggaagag ctgcagctca ccaggtctga     1200

gctagaggct gcacaccatg ccagtgcagt cagattctcc aaggaatatg aaatgcagaa     1260

aacaaaagag gaagactttt tgaagttatt tgacaggtgg aaagaagaag aaaaggagaa     1320

actagttgat gaaatggaaa aagtcaagga gatgtttatg aaggaattta aagaattaac     1380

ttcgaagaat tcagcattag aatatcaact gtcagaaatc cagaagtcca atatgcagat     1440

caagtccaac ataggcacat taaaagatgc acacgagttt aaagaagacc gttctccata     1500

tccccaggat ttccataatg tcatgcagct tcttgatagt caggaaagca aatggacagc     1560

tcgagttcaa gctattcatc aagaacacaa gaaagagaag ggtcggctcc tgtcacatat     1620

agagaaactt cgaacctcaa tgatagatga tctaaatgca agcaatgttt tctataagaa     1680

aaggatagaa gagctagggc agagactcca ggagcagaat gagctgatta taactcagag     1740

acagcagatt aaagacttta cctgtaatcc attaaacagt atcagtgaac ccaaaggaaa     1800

tcctttagcc tggcaggctt ttgaatctca gccagctgct ccagctgtgc ctatgaatgc     1860

cccagccctg cacactttgg aaactaaatc aagtctgcca atggtgcatg aacaggcatt     1920

ctcgtcgcac atactggaac caatagaaga actttcagag gaagaaaaag gaagggaaaa     1980

tgaacagaaa ttaaataaca acaaaatgca tttaaggaaa gctttgaaga gtaactcctc     2040

cctcactaag ggactaagaa caatggtgga gcagaacttg atggagaaac tggaaacctt     2100

ggggattaat gcagatatac gtggcatttc aagtgatcag ttgcatagag tactaaaaag     2160

tgtggaatca gaaagacata agcaagaaag agaaatacct aactttcatc aaattcgaga     2220

attccttgaa catcaagtca gctgtaaaat tgaggagaaa gcactactct cttcagatca     2280

gtgcagtgtt tctcaaatgg ataccctttc aactggagaa gtacccaaaa tgatacaact     2340

tccttccaaa aacagacaac tgattagaca aaaagctgtt tctactgata ggacatctgt     2400

tccaaaaatt aagaaaaatg tcatggaaga tccttttccc agaaagtctt caactattac     2460

gacccctcct tttagttcag aggaggagca ggaggacgac gacctcatcc gggcatacgc     2520

atccccaggc ccacttcctg tgccgccacc acaaaacaag ggcagcttcg ggaagaacac     2580

agtgaaaagt gacgcggacg ggaccgaggg aagcgaaatc gaggacactg atgattctcc     2640

caagcccgca ggagtcgccg ttaaaacacc tactgaaaaa gttgaaaaga tgtttccaca     2700

tcgcaaaaat gtgaacaaac cagtcggtgg aactaatgtc cctgagatgt ttatcaaaaa     2760

agaagaatta caagaactaa agtgtgcgga tgtggaggat gaagactggg acatatcatc     2820

cctagaggaa gagatatctt tgggaaaaaa atctgggaaa gaacagaagg aacctccacc     2880

tgcgaaaaat gaaccacatt ttgctcatgt gctaaatgcc tggggcgcat ttaatcctaa     2940

ggggccaaag ggagaaggac ttcaagaaaa tgaatcaagc acattaaaaa gcagcttagt     3000

aactgtgact gattggagcg acacttcaga tgtctaattc cacatgtcag aagattattc     3060

cagaagccag cagtatttca gtatcacagt gtttcagtaa tttgcctcca tgattctagt     3120

gcttctgcct taccgtgttt cccacagcaa cacagagact gattcaaaga acaatggtct     3180

ctttaatggc acccaataca gtattgaaaa tcagatcatc aacagtattt cgaagcatgt     3240

aaaggtgttt aagacttccg ctgctgctta aaaataacat gtcattgaag tcataaaaag     3300

ttttttcttc agaaaggtac tctagtgtta agtgtatttt tttcaactaa ttttttagtg     3360

aatttttttt aaacttacag catgttttgg tttgaattac taaaacttta aaaaatattt     3420

ttcttatgta tgctgtcgta tcgtaggcgt ttatattata aaattctgtt agtagtctta     3480

aaattgaatt ggtggaacca ctaatcctta aaagttagtc tggttatttt tcatatagaa     3540

gtaagtttaa tccgagtgtg gtggtgttca cctttaatcc cagctacttg ggaggctgag     3600

gtgggaggat aacttgagca caggagttca agaccagcgt gggcaatata gcaagactcc     3660

acccctccac accccaaaaa agtaagttta ggattagaat atagctaggt ccaatgttaa     3720

atacattttc ctggagtaca tttgtcacat tcagctttga gccactgtaa gcatgttact     3780

attaaatggt tggttatttt atatagcata ttctttatct tggatatttt atgaataaag     3840

tatagttatt ttaagtgcca attaatttat cagactaaat agaaaatatt tgagccatta     3900

ctgaattcac atatgtatgt ttttttttac tatttaaaat acccaacatg tattatgaaa     3960

tacctcaaaa gtaatttagt tacattctta aacaatgaca ttgtcgaaag aaagttctta     4020

taagctgttt tttgcatttt tataacttgg ttatactata ttctgtttcc aagtaacctt     4080

ttaactaaaa gatttgttgg gttttagatc tcttttcatt tgtcaacctt ttcagtaaag     4140

ccctctgtta catcactgtg actgtggctg tgttattaga gatgaattct gagttaaatt     4200

tgtacttatt aggggtctta cagagggaga atctggcctt gattgctatg ccatatgaca     4260

ttctgtccta atggttagaa caaatcttta tctgtttcca cccaccctgg gatccttttt     4320

acttgtagcc cattcctgcc ctctaaaaga atccttccaa cttcctatag gggccatttc     4380

atgcagatat actcacttta tatgtatgtt tctaaaagct ttagtgaagg ctgaatccaa     4440

gtttcatgta gtaggacaga gaacagaagg ccgaatccaa gtttcatgtg gtaggacaga     4500

gaacggcaat ctacaaaact acaccaagcc taagatggcc catgtgccac tttgttcatt     4560

catttattta ttcagcagat atttattgaa ccacttggtc tggtttggtt ttgaacacgc     4620

actaattcat ttaattacaa caactttgcg atgtagttat tgttataatc ctcatcctaa     4680

aggtgtgaga aacagagtta ttaagtaagt tgccagaagc catacaagta caaagtgtca     4740

aggggagact ttaagccagg tctctattcc atgttttgtg tctgccatgt tttcattcct     4800

gagcagaaga gcttggggaa atgaactttt gctaagtaaa cccagtattt aaattaagtc     4860

actatatctg tgtcttttaa gagcccctcc tttagcttac atggttagtt gtatcttttt     4920

tttttttttt ttttgagaca gagtctcact atgttgccca ggcttgagcg cagtggcacc     4980

atctcggctc actacaacct ccgcctccca gattcaagcg attttcctgc ctcagcctcc     5040

caagtagctg ggattacagg tgcccaccac catgcctggc ttaatttttt gtatttttag     5100

tagagatgag gtttcaccat gttggccaga ctggtctcga actcctgacc tcaaatgatc     5160

cgctgtcttg tcctcccaaa gtgctgggat tataggcgtg agccatcgcg ccctgctgca     5220

tttcattttt ttgtataaaa tttggtttgt tcgtttttga ggggaaccat tcctttatgt     5280

tgccccttac tgatgcccaa ctaatgtgtt tctggttact aacagacctt catcccccac     5340

cctccctaaa ttcttcggtg taatctaagc gttatctgca ccacttctga ataataaatg     5400

tgtttgaaat gcacacctac acaaccctgt cccacactgg cctgtaggac ctaatctacc     5460

ttcatgtctt tcagttgatt tgtatttctg caaaagatat ttcaaggatt atcaaggtat     5520

ggaatttttt ttatttttta tcttttaaca aacttgttca tttccttttc tttccattga     5580

gcacctctga acaatgtgat tctttttttt aagtctttca cacttcagga aaatactaca     5640

ttcacccacg ttgtgattca tatcggacag tttcttactc aaagataaca caaataccaa     5700

ttcttattca tactttgaaa ctatatttta ccctagactg ccttggttca aaggcctagt     5760

ttcgacatta ctgtggcaaa ttatttaagc tctctgtttt catttctttt tctgtaaatg     5820

caggatgaaa acaatatgta tctcctagga tggctgtgag gagtgagtga gacaggacat     5880

gaaaggtgtg tatgaactgt gataactgtt gcccttgtgg gcatgttata tagggctggc     5940

tctaggaaga agcctgtgtc ttttttcaga aatccctgga gcaacttaaa tgtctttaga     6000

aatgacaagt ctctcagtta tccagttagc cgtaaacagg ttctggaaga cacacctaga     6060

tagaactcgg cccgtcagtt ctgagtgagg cacgtaccac ttgggcttgg gatgtcctta     6120

acccatttat gcctgaggtt gcaatttttt gaatttttcc aatcacacct tggcgatgac     6180

cttgagcagt aggatataaa taactcccac atgcttagtg ttccaataat ggaacactag     6240

gcataaacag gttttaattg gctcctcagt caaccatgac caatatctct atctcagctt     6300

ctgctgatgc cctagctcag ggctctgcat tccgtgccag ggacgcctca gccccttaac     6360

atggatgtgc cacatgacag gcaataatat attggcccca ttagcccttc ctggagcagt     6420

cataatgaat tacagtcatg acaggcacat gtaagaaacc aaaatttgct aaatatgtac     6480

atgagtcttc atcacagcat cgtttatgaa aacaactaaa tattcactaa tggtgccagt     6540

ggaataaatc agagaacatc ccctgctacg taactctctg catacatcaa agagaatggt     6600

gtggctttgc tttttcaaca atctactgag tggccatggg catgtggata tggccatgaa     6660

tgagcaagat cctctctgat cctgtagaag ttaagttcta ccagataact tgctgcttca     6720

acaaaaagat ttaccttttt aaataaatgt tgtagaatac ttaaaaaaaa caaactagaa     6780

tttgcctgtg tgcagccagt aacatgtcta tttaacctgg acaccttttg aggaatattc     6840

tcagattgcc cccatgctgt ttataagaca ttgttcctta tacacctgtt tatgaatgaa     6900

aagaaacata aggagtgggt acaaagactt ctatctatga atgattaaaa aggctagagt     6960

acgaatactt cttgaacctt tggtactaaa tgcttttcat gttctatata aatgtagaaa     7020

acattttaca aatcctgtaa ataaactgtt tattttttat agaaagcc                  7068


<210> 1288
<211> 2404
<212> DNA
<213> Homo sapiens

<400> 1288
agacccgtca aaacaattgc ctcgagcggc agccatcatg gatttaaagg ggcagtaccg       60

gcaagagcgg cagccacacc ggcagattgc agaccgggca aggtccccca ggccaggatg      120

tcaggcctgg tgttggggca gcgggatgag cctgcaggcc accggctcag ccaagaggag      180

atcctgggga gcacacggct ggtcagccaa gggctagagg ccctacgcag tgaacaccag      240

gccgtgctgc aaagcctgtc ccagaccatt gagtgtctgc agcagggagg ccatgaggaa      300

gggctggtgc atgagaaggc ccggcagctt cgccgttcta tggaaaacat tgagctcggg      360

ctgagtgagg cccaggtgat gctggctcta gccagccacc tgagcacagt ggagtcggag      420

aaacagaagc tgcgggctca ggtgcggcgg ctatgccagg agaaccagtg gctgcgggat      480

gagctggctg gcacccagca gcggctacag cgcagtgaac aggctgtggc tcagctggag      540

gaggaaaaga agcacctgga gttcctgggg cagctgcggc agtatgatga ggatggacat      600

acctcggagg agaaagaagg cgatgccacc aaggattccc tggatgacct ctttcctaat      660

gaggaggaag aggaccccag caatggcttg tcccgtggtc aaggtgctac agcagctcag      720

cagggtggat atgagatccc agcaaggttg cggacgttgc acaacctggt gatccagtac      780

gcagcccaag gtcgctatga ggtggccgtg ccactctgta agcaggcact agaggacctg      840

gagcgcacat caggccgtgg ccaccctgat gtcgccacca tgctcaacat ccttgctttg      900

gtgtatcgtg accagaataa gtataaggaa gctgcccacc tgctgaatga tgcccttagc      960

atccgggaga gcaccttggg acctgaccat cctgctgtgg ctgccacact caacaatttg     1020

gctgtgctct atggcaaaag gggcaagtac aaggaggcag agcctctgtg ccagcgggca     1080

ctggagattc gagaaaaggt cctgggcacg aatcatccag atgtggcaaa acagctgaac     1140

aacctggccc tcttgtgcca aaaccagggc aagtatgagg ccgtggaacg ctactaccag     1200

cgagcactgg ccatctacga ggggcagctg gggccggaca accctaatgt agcccggacc     1260

aagaacaacc tggcttcctg ttacctgaaa cagggcaaat atgctgaggc tgagacacta     1320

tacaaagaga tcctgacccg tgcccatgta caggagtttg ggtctgtgga tgatgaccac     1380

aagcccatct ggatgcatgc agaggagcgg gaggaaatga gcaaaagccg gcaccatgag     1440

ggtgggacac cctatgctga gtatggaggc tggtacaagg cctgcaaagt gagcagcccc     1500

acagtgaaca ctactctgag aaacctggga gctctgtata ggcgccaggg aaagctggag     1560

gctgctgaga ccctggagga atgtgccctg cggtcccgga gacagggcac tgaccctatc     1620

agccagacga aggtggcaga gctgcttggg gagagtgatg gtagaaggac ctcccaggag     1680

ggccctggag acagtgtgaa attcgaggga ggtgaagatg cttctgtggc tgtggagtgg     1740

tccggggatg gcagtgggac cctgcagagg agtggctctc ttggcaagat ccgggatgtg     1800

ctccgcagaa gcagtgaact cttggtgagg aagctccagg ggactgagcc tcggccctcc     1860

agcagcaaca tgaagcgagc agcctccttg aactatctga accaacctag tgcagcaccc     1920

ctccaggtct cccggggcct cagtgccagc accatggacc tctcttcaag cagctgacat     1980

tcaacccggc ccccaggtct gctgggtccc cccaccccca cagccctcac agcattcccc     2040

attgctcctg gctcttcccc acccctaggt gggacagtga aggggagcag tttaaccaga     2100

agattgctgc tgcccttagg gtctcagctc cctcctcagg aatccctctt aggaaggacc     2160

ctcaggacac cctctctgca ccctgtggtc ctctagagta gctagctctg aggccccaag     2220

gtgggtacaa agcaggtatg gccctcagag atgcagcctg ctgctggctt ttcagtcaga     2280

gggttggggg ctggccagcc aagctgcctt gccctggccg ctcttactcc ctccctctgc     2340

tgtctcactt caggtccatg tatttcactt ttcttaaata aaagaatcag gtaacctttc     2400

tgtg                                                                  2404


<210> 1289
<211> 1744
<212> DNA
<213> Homo sapiens

<400> 1289
gcacatttgg ctatttttca aagagagcat gtagttcaag aaatggctta ttttgttttt       60

tattcttctt tttgtggtct atttaggaaa acaaaatgaa ggaacagcta ccggacctgc      120

atagccattt ttctgatctg aacctggaag ctcatatgta tgcatcccag tggtttctca      180

ctctttttac tgccaagttc ccactctgca tggtgttcca catcattgac ttactgcttt      240

gtgagggttt gaacataatc tttcatgtag ctttggctct cctaaagacc tcaaaggaag      300

accttctgca ggctgatttt gaaggtgctt taaagttctt tagagttcag cttccaaaga      360

gatacagggc agaggaaaat gcaagaagac tgatggagca ggcttgcaat attaaagtac      420

caaccaagaa gctgaagaaa tatgagaaag aatatcagac aatgcgagag agtcagctgc      480

aacaggaaga cccaatggat agatacaaga gggagaaccg aagattacag gaggccagca      540

tgaggttgga acaagagaat gatgaccttg cccatgaact agtaacaagc aaaattgctc      600

tacggaatga cttggatcag gcagaagaca aggcagatgt gttgaataaa gagctccttt      660

tgaccaaaca gaggctggtg gagactgaag aggagaagag gaagcaagag gaagagactg      720

cccagctaaa agaagtcttc aggaaacagc tagagaaggc agaatatgaa ataaagaaga      780

ctacagctat cattgctgag tataaacaga tctgttcgca gttgagtacc aggctggaga      840

aacagcaagc agccagcaag gaggagctgg aagtggtaaa gggtaagatg atggcatgca      900

aacactgcag tgacattttc agcaaggagg gtgctttgaa actagcagcc acaggcagag      960

aggaccaggg aattgaaaca gatgatgaga aggactcact taagaagcag ctgagagaga     1020

tggaactgga actggcacaa accaaactgc agttggtgga ggccaagtgt aaaattcagg     1080

aacttgaaca tcagagagga gcccttatga atgaaatcca agctgcgaaa aactcttggt     1140

ttagcaaaac cctgaactct atcaaaacgg ccacgggcac ccagccattg cagccagcac     1200

cggtcaccca gccacccaag gagagcacat agttccagcc ttacccaagc acaagagcac     1260

aatgttcaaa ccaatggaaa tctgggagga ttcttcctgg tgtccctttg aaggaaagtc     1320

aaggaggcca gaaaacaagc cagaattttt cagtagctct cactctttct tgtatgacac     1380

ttttcaaagg gatgctattt aaactgacct gttctatgtt gaatacctat tttccagctt     1440

ctggaaggcc atgttcagat ccatcatagt attacacatt attttgtttg cctgatgttt     1500

agttggaaat aagtaattca gaactaaatg cttttttatt tagaattatt cataattatt     1560

tttatcttac ataaaaatgg agacatctgt tattccaagg ttgaagtgat aagaagatct     1620

ttgtcacagg aaaaaaaaaa ttgaaaccta aacatcttaa gttttcagga tttattcaga     1680

taaagcacac tgtggggcca ggcatgacca ctctcaggtt tcctcctgag cctgattccc     1740

aggg                                                                  1744


<210> 1290
<211> 2904
<212> DNA
<213> Homo sapiens

<400> 1290
gttcgcctct cttcggccct ctactcaaga gctccgtctc cgtctcgccc tcctcgaagt       60

cctcgtcgcg cgcccgcgac ccaggtcgcc ctgaaatcta gcccgtccga gcgcgagtcc      120

aacgccgcgg ccgcaccaag gccccctcag accgtgccat gggtgacagt gatgacgagt      180

acgatcgaag gcgcagggac aagttcagaa gagagcgcag cgactacgac cgttcccgcg      240

agagagatga aagacgtcga ggggacgatt ggaatgacag agagtgggac cgtggccgtg      300

agcgccgtag tcggggtgaa tatcgggact atgaccggaa tcggcgagag cgcttctcgc      360

cacctcgcca cgaactcagc ccgccacaga agcgcatgag gagagactgg gatgagcaca      420

gctctgaccc ataccacagt ggctatgaga tgccctatgc tggggggggt gggggcccaa      480

cttatggccc ccctcagccc tggggccacc ctgacgtcca catcatgcag caccatgtcc      540

tgcctatcca ggccaggctg ggcagcattg cagagattga cctgggtgtg ccgccgcccg      600

tgatgaagac cttcaaggag tttctcctct ccctggatga ctcggtggat gagacggagg      660

ccgtcaagcg ctataatgac tacaagctgg atttccggag gcaacagatg caggatttct      720

tcctggcgca caaagatgag gagtggtttc ggtctaagta ccacccagat gaggtgggga      780

agcgtcggca ggaggcccgg ggggccctgc aaaaccgact gagggtcttc ctgtccctca      840

tggagactgg ctggtttgat aaccttctcc tggacataga caaagctgat gccattgtca      900

agatgctgga tgcagccgtg attaagatgg aaggaggcac ggagaatgat cttcgcatcc      960

tggagcagga ggaggaggag gagcaggcag gaaagcctgg ggagcccagc aagaaagaag     1020

aaggacgggc tggagcaggc ctaggggacg gggagcgcaa aaccaacgac aaggatgaga     1080

agaaggaaga cggcaagcag gctgagaatg acagttctaa tgatgacaaa acaaagaagt     1140

cggagggtga tggggacaag gaagagaaga aagaagactc cgagaaggaa gccaaaaaga     1200

gtagcaagaa gcggaaccgg aagcacagtg gtgacgacag ctttgacgag ggcagcgtgt     1260

cagagtctga gtcggagtca gagagcggcc aggctgagga ggagaaggag gaggccgaag     1320

aagcgctcaa ggagaaggag aagcccaagg aagaagaatg ggagaagccc aaggacgccg     1380

cggggctgga gtgcaagccg cggccgctgc ataagacctg ctccctcttc atgcgcaaca     1440

tcgcgcccaa catctcccgg gccgagatca tctccctttg taaaaggtac ccaggcttta     1500

tgcgggtggc gctctcagag ccccagccag agaggaggtt tttccgtcgt ggctgggtga     1560

ccttcgaccg cagtgttaac attaaagaga tctgttggaa cctgcagaac atccgtctcc     1620

gggagtgtga gctgagccct ggtgtgaaca gggacctgac ccggcgcgtt cgcaacatca     1680

acggcatcac ccagcacaag cagattgtgc gcaacgacat caagctggcg gccaagctga     1740

tccacacgct ggatgacagg acacagcttt gggcctcaga accagggacg cctcccctgc     1800

ccacgagcct gccctcgcaa aacccgatct tgaagaatat caccgactac ctgatcgagg     1860

aagtaagcgc cgaggaggag gagctgctgg ggagcagcgg gggcgctcct cctgaggagc     1920

ctcctaagga agggaacccg gcagagatca acgtggagcg ggatgagaag ttgattaagg     1980

tcttggacaa gctcctcctt tacctgcgca tcgtgcattc cttggattat tacaacacct     2040

gtgagtaccc caacgaggac gagatgccca atcgctgtgg gatcatccac gttcgggggc     2100

ccatgccacc caaccgcatc agtcacgggg aagtgctgga gtggcagaag acttttgagg     2160

agaagctcac gccgttgctg agtgtgcggg agtcactctc agaggaagag gcccagaaga     2220

tggggcgcaa agacccagag caggaagtgg agaagttcgt cacctccaac acgcaggaac     2280

tgggcaagga taagtggctg tgtcctctca gtggcaagaa attcaagggt cctgagtttg     2340

tgcgcaaaca tatcttcaac aagcatgcag agaaaattga ggaagtgaaa aaggaagtcg     2400

cgttttttaa caacttcctc actgatgcta agcgcccagc tctgcctgag atcaagccag     2460

cccagccacc tggccccgcc cagatactcc ccccaggttt gaccccagga ctcccctacc     2520

cacaccagac tccccagggc ctgatgccct atggtcagcc ccggcccccg atcttgggct     2580

atggagctgg tgctgtccgc cctgcagtcc ccacaggagg ccctccatac ccccatgccc     2640

cgtatggtgc tggtcgaggg aactatgatg ccttccgagg ccagggaggt tatcctggga     2700

aacctcgcaa caggatggtt cgtggagacc caagggccat tgtggaatat cgggacctgg     2760

atgccccaga cgatgttgat ttcttttgag ccgtcccccg ttcctcagtc ctgtatcatc     2820

catacttgta ctaccttgtc ctatgaagct ctgagaattt tttgtacgat cagccttact     2880

gctaataaaa gcacttccac aggg                                            2904


<210> 1291
<211> 3136
<212> DNA
<213> Homo sapiens

<400> 1291
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc agaaagcata acccctactg tagaactaaa tgcactgtgc atgaaacttg      300

gaaaaaaacc aatgtataag cctgttgacc cttactctcg gatgcagtcc acctataact      360

acaacatgag aggaggtgct tatcccccga ggtactttta cccatttcca gttccacctt      420

tactttatca agtggaactt tctgtgggag gacagcaatt taatggcaaa ggaaagacaa      480

gacaggctgc gaaacacgat gctgctgcca aagcgttgag gatcctgcag aatgagcccc      540

tgccagagag gctggaggtg aatggaagag aatccgaaga agaaaatctc aataaatctg      600

aaataagtca agtgtttgag attgcactta aacggaactt gcctgtgaat ttcgaggtgg      660

cccgggagag tggcccaccc cacatgaaga actttgtgac caaggtttcg gttggggagt      720

ttgtggggga aggtgaaggg aaaagcaaga agatttcaaa gaaaaatgcc gccatagctg      780

ttcttgagga gctgaagaag ttaccgcccc tgcctgcagt tgaacgagta aagcctagaa      840

tcaaaaagaa aacaaaaccc atagtcaagc cacagacaag cccagaatat ggccagggga      900

tcaatccgat tagccgactg gcccagatcc agcaggcaaa aaaggagaag gagccagagt      960

acacgctcct cacagagcga ggcctcccgc gccgcaggga gtttgtgatg caggtgaagg     1020

ttggaaacca cactgcagaa ggaacgggca ccaacaagaa ggtggccaag cgcaatgcag     1080

ccgagaacat gctggagatc cttggtttca aagtcccgca ggcgcagccc accaaacccg     1140

cactcaagtc agaggagaag acacccataa agaaaccagg ggatggaaga aaagtaacct     1200

tttttgaacc tggctctggg gatgaaaatg ggactagtaa taaagaggat gagttcagga     1260

tgccttatct aagtcatcag cagctgcctg ctggaattct tcccatggtg cccgaggtcg     1320

cccaggctgt aggagttagt caaggacatc acaccaaaga ttttaccagg gcagctccga     1380

atcctgccaa ggccacggta actgccatga tagcccgaga gttgttgtat gggggcacct     1440

cgcccacagc cgagaccatt ttaaagaata acatctcttc aggccacgta ccccatggac     1500

ctctcacgag accctctgag caactggact atctttccag agtccaggga ttccaggttg     1560

aatacaaaga cttccccaaa aacaacaaga acgaatttgt atctcttatc aattgctcct     1620

ctcagccacc tctgatcagc catggtatcg gcaaggatgt ggagtcctgc catgatatgg     1680

ctgcgctgaa catcttaaag ttgctgtctg agttggacca acaaagtaca gagatgccaa     1740

gaacaggaaa cggaccaatg tctgtgtgtg ggaggtgctg aaccttttct ggccatgaac     1800

cattataaaa tcccaacata tatactgaaa atactgaaac tgctttgaaa atttggaatt     1860

tctgatacct ccagtgggcc gagagacacg gtgggtaaag gatgtgggca gcagcaggga     1920

agacaacaga aacacaagga ggcggctgtg gccgggctgg actgtgctgg ggtttgttgt     1980

gatggccact cggtgacctg gcggtcccta cgcaatagca gctgcctgtg gggaagaagg     2040

gctgcccagc cagctggttc tcccgggaca ccagcagatc cacaccctgg gcacctccgt     2100

gtttggtctt ttttttcccc tgtgtgaaag aagaaacggc acgacccctt ctcaagctgg     2160

ctcactcaga cacattggga caaaccctgg acagccatgc cagagagagg cctttgaccg     2220

gccccagagc taaaagcacc agagaaaatc aaatgcttcc tactcagcgt gacccaactt     2280

ttctagtgtg ccacggcccc accacctcct gcagtaccca caccatcacc actgctttct     2340

cttccaacag tgatctgtat tcttagtttc attattttct tttgattgat atgacactat     2400

ataaaatttt catttgagaa tttctcaatt gtatctagtt aaatagcaca gtttggaaac     2460

ttgtctgaga ctgactttat caataatcta accgacaaag atcatatcca tgtgtatgtg     2520

gttagacatt tttatttcat tgactaaccc aggacagttt cagtgatgca aattgtgtgc     2580

cctctggttc agctgaaaca gtcctggact ttcaaaaacc ttgaataagt ctcccacagt     2640

tgtataaatt ggacaattta ggaattttaa actttagatg atcatttggt tccattttta     2700

tttcattttt atttttgtta atgcaaacag gacttaaatg aactttgatc tctgttttaa     2760

agattattaa aaaacattgt gtatctatac atatggctct tgaggactta gctttcacta     2820

cactacagga tatgatctcc atgtagtcca tataaacctg cagagtgatt ttccagagtg     2880

ctcgatactg ttaattacat ctccattagg gctgaaaaga atgacctacg tttctgtata     2940

cagctgtgtt gcttttgatg ttgtgttact gtacacagaa gtgtgtgcac tgaggctctg     3000

cgtgtggtcc gtatggaaag cctggtagcc ctgcgagtta agtactgctt ccattcattg     3060

tttacgctgg aatttttctc cccatggaat gtaagtaaaa cttaagtgtt tgtcatcaat     3120

aaatggtaat actaaa                                                     3136


<210> 1292
<211> 429
<212> DNA
<213> Homo sapiens

<400> 1292
gagtagatat cccggagttc cgcgcggcgc cagcccttcc gccacggccg tctctggaga       60

gcagcagcca tggccctacg ctaccctatg gccgtgggcc tcaacaaggg ccacaaagtg      120

accaagaacg tgagcaagcc caggcacagc cgacgccgcg ggcgtctgac caaacacacc      180

aagttcgtgc gggacatgat tcgggaggtg tgtggctttg ccccgtacga gcggcgcgcc      240

atggagttac tgaaggtctc caaggacaaa cgggccctca aatttatcaa gaaaagggtg      300

gggacgcaca tccgcgccaa gaggaagcgg gaggagctga gcaacgtact ggccgccatg      360

aggaaagctg ctgccaagaa agactgagcc cctcccctgc cctctccctg aaataaagaa      420

cagcttgac                                                              429


<210> 1293
<211> 3792
<212> DNA
<213> Homo sapiens

<400> 1293
atggcgaacg actcccctgc aaaaagtctg gtggacatcg acctctcctc cctgcgggat       60

cctgctggga tttttgagct ggtggaagtg gttggaaatg gcacctatgg acaagtctat      120

aagggtcgac atgttaaaac gggtcagttg gcagccatca aagttatgga tgtcactgag      180

gatgaagagg aagaaatcaa actggagata aatatgctaa agaaatactc tcatcacaga      240

aacattgcaa catattatgg tgctttcatc aaaaagagcc ctccaggaca tgatgaccaa      300

ctctggcttg ttatggagtt ctgtggggct gggtccatta cagaccttgt gaagaacacc      360

aaagggaaca cactcaaaga agactggatc gcttacatct ccagagaaat cctgagggga      420

ctggcacatc ttcacattca tcatgtgatt caccgggata tcaagggcca gaatgtgttg      480

ctgactgaga atgcagaggt gaaacttgtt gactttggtg tgagtgctca gctggacagg      540

actgtggggc ggagaaatac gttcataggc actccctact ggatggctcc tgaggtcatc      600

gcctgtgatg agaacccaga tgccacctat gattacagaa gtgatctttg gtcttgtggc      660

attacagcca ttgagatggc agaaggtgct ccccctctct gtgacatgca tccaatgaga      720

gcactgtttc tcattcccag aaaccctcct ccccggctga agtcaaaaaa atggtcgaag      780

aagtttttta gttttataga agggtgcctg gtgaagaatt acatgcagcg gccctctaca      840

gagcagcttt tgaaacatcc ttttataagg gatcagccaa atgaaaggca agttagaatc      900

cagcttaagg atcatataga tcgtaccagg aagaagagag gcgagaaaga tgaaactgag      960

tatgagtaca gtgggagtga ggaagaagag gaggaagtgc ctgaacagga aggagagcca     1020

agttccattg tgaacgtgcc tggtgagtct actcttcgcc gagatttcct gagactgcag     1080

caggagaaca aggaacgttc cgaggctctt cggagacaac agttactaca ggagcaacag     1140

ctccgggagc aggaagaata taaaaggcaa ctgctggcag agagacagaa gcggattgag     1200

cagcagaaag aacagaggcg acggctagaa gagcaacaaa ggagagagcg ggaagctaga     1260

aggcagcagg aacgtgaaca gcgaaggaga gaacaagaag aaaagaggcg tctagaggag     1320

ttggagagaa ggcgcaaaga agaagaggag aggagacggg cagaagaaga aaagaggaga     1380

gttgaaagag aacaggagta tatcaggcga cagctagaag aggagcagcg gcacttggaa     1440

gtccttcagc agcagctgct ccaggagcag gccatgttac tggagtgccg atggcgggag     1500

atggaggagc accggcaggc agagaggctc cagaggcagt tgcaacaaga acaagcatat     1560

ctcctgtctc tacagcatga ccataggagg ccgcacccgc agcactcgca gcagccgcca     1620

ccaccgcagc aggaaaggag caagccaagc ttccatgctc ccgagcccaa agcccactac     1680

gagcctgctg accgagcgcg agaggtggaa gatagattta ggaaaactaa ccacagctcc     1740

cctgaagccc agtctaagca gacaggcaga gtattggagc caccagtgcc ttcccgatca     1800

gagtcttttt ccaatggcaa ctccgagtct gtgcatcccg ccctgcagag accagcggag     1860

ccacaggttc ctgtgagaac aacatctcgc tcccctgttc tgtcccgtcg agattcccca     1920

ctgcagggca gtgggcagca gaatagccag gcaggacaga gaaactccac cagtattgag     1980

cccaggcttc tgtgggagag agtggagaag ctggtgccca gacctggcag tggcagctcc     2040

tcagggtcca gcaactcagg atcccagccc gggtctcacc ctgggtctca gagtggctcc     2100

ggggaacgct tcagagtgag atcatcatcc aagtctgaag gctctccatc tcagcgcctg     2160

gaaaatgcag tgaaaaaacc tgaagataaa aaggaagttt tcagacccct caagcctgct     2220

gatctgaccg cactggccaa agagcttcga gcagtggaag atgtacggcc acctcacaaa     2280

gtaacggact actcctcatc cagtgaggag tcggggacga cggatgagga ggacgacgat     2340

gtggagcagg aaggggctga cgagtccacc tcaggaccag aggacaccag agcagcgtca     2400

tctctgaatt tgagcaatgg tgaaacggaa tctgtgaaaa ccatgattgt ccatgatgat     2460

gtagaaagtg agccggccat gaccccatcc aaggagggca ctctaatcgt ccgccagact     2520

cagtccgcta gtagcacact ccagaaacac aaatcttcct cctcctttac accttttata     2580

gaccccagat tactacagat ttctccatct agcggaacaa cagtgacatc tgtggtggga     2640

ttttcctgtg atgggatgag accagaagcc ataaggcaag atcctacccg gaaaggctca     2700

gtggtcaatg tgaatcctac caacactagg ccacagagtg acaccccgga gattcgtaaa     2760

tacaagaaga ggtttaactc tgagattctg tgtgctgcct tatggggagt gaatttgcta     2820

gtgggtacag agagtggcct gatgctgctg gacagaagtg gccaagggaa ggtctatcct     2880

cttatcaacc gaagacgatt tcaacaaatg gacgtacttg agggcttgaa tgtcttggtg     2940

acaatatctg gcaaaaagga taagttacgt gtctactatt tgtcctggtt aagaaataaa     3000

atacttcaca atgatccaga agttgagaag aagcagggat ggacaaccgt aggggatttg     3060

gaaggatgtg tacattataa agttgtaaaa tatgaaagaa tcaaatttct ggtgattgct     3120

ttgaagagtt ctgtggaagt ctatgcgtgg gcaccaaagc catatcacaa atttatggcc     3180

tttaagtcat ttggagaatt ggtacataag ccattactgg tggatctcac tgttgaggaa     3240

ggccagaggt tgaaagtgat ctatggatcc tgtgctggat tccatgctgt tgatgtggat     3300

tcaggatcag tctatgacat ttatctacca acacatatcc agtgtagcat caaaccccat     3360

gcaatcatca tcctccccaa tacagatgga atggagcttc tggtgtgcta tgaagatgag     3420

ggggtttatg taaacacata tggaaggatc accaaggatg tagttctaca gtggggagag     3480

atgcctacat cagtagcata tattcgatcc aatcagacaa tgggctgggg agagaaggcc     3540

atagagatcc gatctgtgga aactggtcac ttggatggtg tgttcatgca caaaagggct     3600

caaagactaa aattcttgtg tgaacgcaat gacaaggtgt tctttgcctc tgttcggtct     3660

ggtggcagca gtcaggttta tttcatgacc ttaggcagga cttctcttct gagctggtag     3720

aagcagtgtg atccagggat tactggcctc cagagtcttc aagatcctga gaacttggaa     3780

ttccttgtaa ct                                                         3792


<210> 1294
<211> 4955
<212> DNA
<213> Homo sapiens

<400> 1294
gtgctgtggc ggcggcggcg gcggtagtgg cggcggcggc ggtgcctggg cggcagcagc       60

agcagtagcg gcagccctga ggacggtgag acggccgcgg cggcggcgac agcgcggaag      120

tcgcgcggga cccagagctt cccccctgtc gctagtgctg aggctttcgc ctttcctacc      180

cagcttcttg ctcacggccc gggctgggct gggcagggca acgcgccccc ggggaggggc      240

ggagctgtag atatggtgta agatacttct tcaagattgg acagctgggg accttcttct      300

gattaacctt aaaccaactt gtagccatag agacacctca caaggttccc atttttgttg      360

ttgttgttgt tgattttctg ctcacacctt tcctgacctt gcaaccatgt atggaagtgc      420

ccgctctgtt gggaaggtgg agccgagcag ccagagccct gggcgttcac ccaggcttcc      480

acgttcccct cgcttgggtc accgtcgaac caacagtacg ggagggagtt cgggaagcag      540

tgttggaggt ggcagtggga aaaccctttc aatggaaaat atacaatctt taaatgctgc      600

ctatgccacc tctggcccta tgtatctaag tgaccatgaa aatgtgggtt cagaaacacc      660

taaaagcacc atgacacttg gccgttctgg gggacgtctg ccttacggtg ttcggatgac      720

tgctatgggt agtagcccca atatagctag cagtggggtt gctagtgaca ccatagcatt      780

tggagagcat cacctccctc ctgtgagtat ggcatccact gtacctcact cccttcgtca      840

ggcgagagat aacacaatca tggatctgca gacacagctg aaggaagtat taagagaaaa      900

tgatctcttg cggaaggatg tggaagtaaa ggagagcaaa ttgagttctt caatgaatag      960

catcaagacc ttctggagcc cagagctgaa gaaggaacga gccctgagaa aagatgaagc     1020

ttccaaaatc accatttgga aggaacagta cagagttgta caggaggaaa accagcacat     1080

gcagatgaca atccaggctc tccaggatga attgcggatc cagagggacc tgaatcagct     1140

gtttcagcag gatagtagca gcaggactgg cgaaccttgt gtagcagagc tgacagagga     1200

gaactttcag aggcttcatg ctgagcatga gcggcaggcc aaagagctgt ttcttcttcg     1260

aaagacattg gaggaaatgg agctgcgtat tgagactcaa aagcagaccc taaatgctcg     1320

ggatgaatcc attaagaagc ttctggaaat gttgcagagc aaaggacttt ctgccaaggc     1380

taccgaggaa gaccatgaga gaacaagacg actggcagag gcagagatgc acgttcatca     1440

cctagaaagc cttttggagc agaaggaaaa agagaacagt atgttgagag aggagatgca     1500

tcgaaggttt gagaatgctc ctgattctgc caaaacaaaa gctctgcaaa ctgttattga     1560

gatgaaggat tcaaaaattt cctctatgga gcgtgggctt cgagacctgg aagaggaaat     1620

tcagatgctg aaatcgaatg gtgctttgag tactgaggaa agggaagaag aaatgaagca     1680

aatggaagtg tatcggagcc attctaaatt tatgaaaaat aagattggcc aggtgaaaca     1740

ggagctgtcc agaaaggaca cagaactact cgccctgcag acaaagctag aaacactcac     1800

aaaccagttc tcagatagta aacagcacat tgaagtgttg aaggagtcct tgactgctaa     1860

ggagcagagg gctgccatcc tgcagactga ggtggatgct ctccgattgc gtttggaaga     1920

gaaggaaacc atgttgaata aaaagacaaa acaaattcag gatatggctg aagagaaggg     1980

gacacaagct ggagagatac atgacctcaa ggacatgttg gatgtgaagg agcggaaggt     2040

taatgttctt cagaagaaga ttgaaaatct tcaagagcag cttagagaca aggaaaagca     2100

gatgagcagc ttgaaagaac gggtcaaatc cttgcaggct gacaccacca acactgacac     2160

tgccttgaca actttggagg aggcccttgc agagaaagag cggacaattg aacgcttaaa     2220

ggagcagagg gacagagatg agcgagagaa gcaagaggaa attgataact acaaaaaaga     2280

tcttaaagac ttgaaggaaa aagtcagcct gttgcaaggc gacctttcag agaaagaggc     2340

ttcacttttg gatctgaaag agcatgcttc ttctctggca tcctcaggac tgaaaaagga     2400

ctcacggctt aagacactag agattgcttt ggagcagaag aaggaggagt gtctgaaaat     2460

ggaatcacaa ttgaaaaagg cacatgaggc agcattggaa gccagagcca gtccagagat     2520

gagtgaccga atacagcact tggagagaga gatcaccagg tacaaagatg aatctagcaa     2580

ggcccaggca gaagttgatc gactcttaga aatcttgaag gaggtggaaa atgagaagaa     2640

tgacaaagat aagaagatag ctgagttgga aagtctcacc tcaaggcaag tgaaagacca     2700

gaataagaag gtagcaaatc tgaagcacaa ggaacaggtg gaaaaaaaga agagtgcaca     2760

aatgttagag gaggcgcgac gacgggagga caatctcaac gacagctctc agcagctaca     2820

ggtggaggag ttactgatgg ccatggagaa ggtaaagcag gaactagaat ccatgaaagc     2880

aaagctgtcc tccacccagc agtctctggc agaaaaggaa actcacttga ctaatcttcg     2940

ggcagagaga aggaaacact tagaggaagt tctggagatg aagcaagaag ctcttctggc     3000

tgccattagt gaaaaagacg ccaatatagc tctcttggag ctttcgtcct ctaagaagaa     3060

gacccaagag gaagtggctg ccctgaagcg ggagaaggat cgtctggtac agcagcttaa     3120

gcagcagacg caaaatcgaa tgaagctaat ggccgacaac tacgaggatg accacttcaa     3180

atcctcccat tccaatcaaa caaatcacaa gccctcccca gaccaggatg aggaggaggg     3240

tatatgggca tagccaatca gaggcttagt tcagccattt tgttcagaac gatcatccag     3300

cccctcttag aacttgacca aaatagaagt aaattaaagt tgtacattgg acacctgaca     3360

accctctgcc atgaccgaga ccccctgatc ctccgtggac tcactccacc agcttcctat     3420

aacttggacg atgaccaggc ggcttgggag aatgagctgc agaagatgac ccgggggcag     3480

cttcaggatg agttagagaa aggtgaacgg gacaatgcag aactgcagga gtttgccaac     3540

gccattcttc agcagatagc agaccattgt cccgacatcc tagagcaagt ggtcaacgcc     3600

ctggaagagt cctcttgacc ctgctttatg gggaagcctg aggtagtcaa cccaggagcc     3660

aagaaaagag aactacgagg aacaggtgcc cggaaccttc ttggcaccaa acactacaaa     3720

cttcatccca acttgctcac ttgaagaagt gtgattccag caccgtttct acatctgcca     3780

tcttactctg cctttctgct ttggatgtgg tctctacact aaccttcttg atgtccaggg     3840

tagataaagg gtcgaatctc tctgaagaac tgccacctgg tcatcagcag tggagaactg     3900

tgggagctgg tggctctgcc ctgacagaga gccatggagc agaggagcct ctcacctcct     3960

gtcctctgac atgagaatga aaccaggaat ggacttggag ttcaacaggc tgagaggatg     4020

cctccaatgg accagagagc tgagtgttct aatatcacaa taggtgcttt ctcctaaaag     4080

ggcaaaaaac aatctcaaaa agattagaaa aagagaaggg gggaagggaa gagaaaatcg     4140

actcttcttt ttactgtctc ttctgcttac tttccacatg agatgctttg taccggggag     4200

ctgtgagcag gcctcacgat ggcttgggag cactcgttct cccaaggtct gagtcttcat     4260

ccagccctgc ctgtctgtcg cagccttcct cactctgttc ctcggccagt taacaagaag     4320

atggtgtgag gtgttctcca ccagtctctc ctgtttgaga ctgttgacgt tatcatactg     4380

aggtgttaga tcaaatatct ctaattgaag aacatgtgag gttgaaagag caccagccag     4440

ggcaacatag cgtgaccctg tctctacaaa aaattaaaaa gagaacatac aaagttgaca     4500

tatgagaccc tgttgtcccc gcctgcagct ttgccccagt aacagatgcc cgttgctctt     4560

gggctggttt cccctgaaca cctccaagag gctgcctgcc ttgccagcac ccgtgtcctg     4620

agctcctgca gcccagtggc tgctgaagtt gtgatccctc actcaccctg ctagctttgc     4680

ccttgactcg tcttctctga acctcagcct cgtgcattgc ctggaacctt cttctagcat     4740

aaatgaaggt ttttcctcct acacacattc cttcctcggt tatttcattc agagaatatt     4800

tatgaaatgc ctactgtgtg caagtcatcc atccttgaaa aggccacttc tcagtgaggg     4860

agagatgtag tggattctgt gagacatacc tgctggagtt gaagcagtaa atagcatgtc     4920

cttcccctcc ccgatcttaa ggtgtgtttt ctaga                                4955


<210> 1295
<211> 2998
<212> DNA
<213> Homo sapiens

<400> 1295
gccggcggga tcccaggcgc cgagcgcccg ctgagcagcc accctttgcg cgccgcctgc       60

agcgcagctt ccccgggcgc tgcctggaca ggcctgcctg cgtgctggga catgtctggc      120

ctccaaggac cgtcggtggg cgatggctgc aacggtggag gggccagagc tggaggcagc      180

tgctgccgca ggagatgctt cagaggattc ggacgcaggg tccagggcgc tgcctttcct      240

gggcggcaac cggctgagct tggacctgta ccccgggggc tgccagcagc tgctgcacct      300

gtgtgtccag cagcctctgc agctgctgca ggtggaattc ttgcgtctga gcactcacga      360

ggaccctcag ctgctggagg ccaccctggc ccagctgcct cagagcctgt cctgcctccg      420

ctccctggtc ctcaaaggag ggcaacgccg ggacacactg ggtgcctgtc tccggggtgc      480

cctgaccaac ctgcccgctg gtctgagtgg cctggcccat ctggcccacc tggacctgag      540

cttcaacagc ctggagacac tgccggcctg tgtcctgcag atgcgaggtc tgggtgcgct      600

cttgctgtct cacaactgcc tctctgagct gcctgaggct ctgggggccc tccccgccct      660

caccttcctc acagtgacac acaaccgcct gcagacgctg cccccagcac tgggggccct      720

atccaccctg cagcgcctcg atctctctca gaatctgctg gacacgctac ctcctgagat      780

tggaggcctg ggcagcctcc tggagctcaa cctggcctcc aaccggctgc agagcctccc      840

agcctctctg gcgggacttc ggtccttgcg gctccttgtc ctgcacagca acctcctggc      900

ctctgtgcca gctgacttgg cccgccttcc actcctcacc cggctcgacc tgagggacaa      960

ccagctccgg gacctgcccc ctgagctgct agacgccccc tttgtgcgcc tgcaggggaa     1020

ccccctgggt gaggcctcgc cagacgcccc gagttcacca gtggcagccc tcattccaga     1080

aatgcccaga ctgttcctga cctcagattt ggacagcttt cctgtgaccc ctcaaggctg     1140

ctcagtgacc ctggcctgtg gcgtccgcct gcagttccca gcgggagcca ccgccacccc     1200

catcaccatc cgctatcggc tgctgctgcc ggagccaggc ctcgtccccc tgggtcctca     1260

tgacgccctg ctcagccatg tgctggagct gcagccccat ggggtggcct tccagcagga     1320

tgtggggctg tggctgctct tcaccccacc gcaggcccgg cgctgccgtg aagtggtggt     1380

caggacccgg aatgacaaca gctggggtga cctggagacc tacctggagg aagaggcacc     1440

ccagcggctc tgggctcact gccaggtgcc ccacttctcc tggttccttg tggtttcccg     1500

ccctgtgtcc aatgcctgcc tggtgccacc ggaggggaca ctgctgtgct cctcgggtca     1560

tcctggggtc aaagtcatct tcccccctgg ggccactgag gagcctcgtc gagtctccat     1620

gcaggtggtg cgcatggctg gccgagagct gcaggccctc ctgggagaac cagaggctgc     1680

agtgagcccc ctgctgtgcc tgtcacagag cggtcccccc agcttcctcc aaccggtcac     1740

cgtgcagctg cctctgccct ctggcatcac aggcctcagt ctggaccgct cccgcctgca     1800

cctgttgtac tgggcccctc ctgcagccac ctgggatgac atcacagctc aggtggtcct     1860

ggagctcacc cacctgtacg cacgcttcca ggtcacacac ttctcctggt actggctctg     1920

gtacaccacc aagaactgtg tgggaggcct ggctcggaag gcctgggagc ggctgcggct     1980

gcaccgtgtg aacctcatcg ctctgcagcg gcgccgggac cctgagcagg tcctgctgca     2040

gtgcctgccc cgaaacaagg tggacgccac ccttcggcgg ctgctggagc ggtaccgggg     2100

ccccgagccc tctgacacgg tggagatgtt cgagggcgaa gagttctttg cggccttcga     2160

gcgcggcatc gacgtggatg ctgaccgccc tgactgtgtg gagggcagaa tctgctttgt     2220

cttctactcg cacctgaaga atgtgaagga ggtatacgtg accaccactc tggaccggga     2280

ggctcaggct gtgcggggcc aggtgtcctt ctaccgtggc gcggtgcctg tgcgggtgcc     2340

cgaggaggct gaggctgccc ggcagaggaa gggcgcagac gccctgtgga tggccactct     2400

gcccatcaag ctgccgagac ttcgagggtc cgaggggcca cggcgggggg ctggcctctc     2460

cttggcaccc ttgaatctgg gagatgccga gaccggcttt ctgacgcaga gcaacctgct     2520

gagtgtggct gggcgtctgg gtctggactg gccagccgtg gccctgcacc tgggggtgtc     2580

ctaccgggag gtgcagcgca tccggcacga gttccgggat gatctggatg agcagatccg     2640

tcacatgctc ttctcctggg ctgagcgcca ggctgggcag ccaggggctg tggggctcct     2700

ggtgcaggcc ctggagcaga gtgaccggca ggacgtggct gaagaggtgc gcgcagtctt     2760

ggagctcggc cgccgcaagt accaggacag catccgacgc atgggcttgg cccccaagga     2820

ccccgctctg cctggctcct cggctccaca gcccccagag cctgcccagg cctaggcccc     2880

acagactttt aggctggccc agatattccc cagtggatgg gcagagcccc caccttcaag     2940

tctctccagt gtgtggggac gggtccctgt gagcaacaaa actgcactgt ttctttca       2998


<210> 1296
<211> 5913
<212> DNA
<213> Homo sapiens

<400> 1296
agagccctag tgtcgtgctc tcctcggtag gggaggaatt ggttaggcgg cggcggcggc       60

gaagcggcgg cggcggctgt aggggagcag cggcagtggc ggcgacggcg aggaggtgtt      120

cggtttgcgc agcgtagaaa cgcccgcagc ttcagagaag gagttcttgt gggaccaaat      180

taggcattct gaacccacgc cggcttagct gggccgagtc caggcgctgc cgcacgtaca      240

gttttggtgg cggtgacaga cactgttctt gactctaggg gcctattagg ccgacgtctg      300

aggcgcagat cgctggctct cgacgcatta ctctttacgc cttacatttc tgtcttcctt      360

cctgggtcag tgattcccgg accctggaag agaagagggt ggctaatgat taaggctttc      420

cttaaagttt cccatgtctc aatggactcc tgaatataac gagctctaca ccttaaaagt      480

ggatatgaag agtgagattc cttctgatgc accaaagaca caggagagtc tgaaagggat      540

ccttttgcat ccagagccca ttggggcagc caaaagtttt cctgcaggag ttgagatgat      600

taatagtaaa gtggggaatg aattctctca cctgtgtgat gattctcaaa agcaagagaa      660

ggaaatgaat ggtaaccagc aagaacaaga aaaaagtctc gttgtgagga aaaaacgcaa      720

aagccagcag gctggccctt cgtatgtgca gaattgtgtt aaagaaaacc agggaatatt      780

aggactgagg caacacctag ggacaccaag tgatgaagat aatgattcct cttttagtga      840

ttgtctttct tctccttcat ctagtctgca ttttggagat tctgatactg tgacttcaga      900

tgaggataaa gaagtctctg taagacattc ccagaccatt ttgaatgcta aaagtagaag      960

ccatagtgca cggtctcata agtggcctcg gactgagaca gaatctgtat cgggattgtt     1020

aatgaaaaga ccctgtttac atggcagttc gttacggaga cttccatgca gaaagagatt     1080

tgtaaaaaat aattcctcac agaggacaca gaaacaaaaa gagaggatat taatgcagag     1140

gaagaaacga gaagtgttag ctcgaagaaa atatgccttg ctacctagtt ctagtagttc     1200

cagtgagaat gacctcagca gtgaatcctc ttctagctca tcaactgaag gagaagaaga     1260

tttgtttgtt tctgccagtg aaaaccacca aaacaatcca gctgttccct caggaagtat     1320

tgatgaagat gttgtggtga tagaagcttc ctccactccc caggttactg ccaatgaaga     1380

aattaatgtt acctcaactg acagtgaagt ggagattgta acagttggag aaagctatcg     1440

gtctcgttca acccttggac actccagatc tcattggagc cagggttcca gttctcatgc     1500

aagtcggcca caggagccac ggaaccgcag taggatttct actgttatac agcccttgag     1560

gcagaatgca gcagaagttg tggaccttac cgttgatgaa gatgaaccta ctgtagtacc     1620

aaccacttct gcaagaatgg aatcacaagc tactagcgct tccattaaca attcaaatcc     1680

atctacctct gagcaggcct ctgatactgc ttcagctgtc accagtagcc aaccttccac     1740

agtgtcagag acttcagcta ctcttacaag caatagtacc actggcactt ctataggaga     1800

tgactcaagg agaactacat ctagtgctgt aacggaaact ggccctcctg caatgccaag     1860

gttaccttcc tgctgtcccc agcactcacc atgtggaggg tcgtcacaga accaccatgc     1920

attaggacat cctcatacaa gttgctttca gcagcatggt caccattttc aacatcatca     1980

ccaccaccac catactcccc acccagctgt cccagtttct ccttccttta gtgatcctgc     2040

ttgccctgtg gaaagacctc cacaagtaca agcaccttgt ggagcaaata gtagttctgg     2100

taccagctat catgaacagc aggcattgcc agtggacctg agcaacagtg gtatcagaag     2160

tcatggaagt ggcagttttc atggagcatc tgcatttgac ccctgctgcc ctgtttcttc     2220

ctcccgagct gcaatctttg gccatcaggc cgctgctgct gccccaagtc aacctttatc     2280

atcaatagat ggctatggat caagcatggt tgcgcagccc cagccccagc cccctccaca     2340

gccctctctc tcatcatgtc gacattacat gccaccccct tatgcctctt tgacaaggcc     2400

acttcatcat caagcttctg cctgcccgca ttctcatgga aacccccctc ctcagactca     2460

gcctccgcct caagtggatt atgttattcc tcatcctgta catgctttcc attctcaaat     2520

atcttctcat gcaacatctc atcctgtggc acccccacca ccaactcact tagccagtac     2580

agctgcacca atccctcagc atcttcctcc tacacaccag ccaatttcgc accatattcc     2640

agccacagca cctccagcac agagactgca tcctcatgaa gtgatgcaga ggatggaagt     2700

tcaaaggagg aggatgatgc agcatccaac gcgggcacat gaacgccccc caccccatcc     2760

acataggatg cacccaaact atggtcatgg gcatcatatt catgtgcctc agactatgtc     2820

ctcacatcct cgacaggctc cagagaggtc tgcctgggaa ctgggaattg aagctggagt     2880

gactgcagct acttatacac ctggtgcatt gcatcctcac ttggcccatt atcacgcacc     2940

tcctcgactt catcacttac aattaggagc tcttccttta atggttcctg atatggcagg     3000

ctatcctcac atccgttaca tttcatcagg attggatgga acatcattca gaggtccttt     3060

caggggcaat tttgaggaac tgattcattt ggaagaaaga ttaggcaatg tcaatcgtgg     3120

agcatcccag gggacaattg aaagatgtac atatccacat aaatacaaaa agaggaaact     3180

gcactgcaaa caagatgggg aagaagggac tgaggaagac acagaggaaa aatgtactat     3240

ctgtttgtct attttagagg aaggtgaaga tgtgagacgt cttccatgta tgcacctttt     3300

ccaccaagtg tgtgttgacc aatggttgat taccaataag aagtgcccca tatgcagagt     3360

ggacattgag gcccagctgc caagtgaaag ttgacaccat gtttcagaac tcttgccctc     3420

cctctcattc ccatccttcc tggtactgca gtcaaccaaa gatggcatga cttacctgcg     3480

cagatttgga agcattgaac ttagagtgct ggctctgcta tatggtacaa ctaatgctag     3540

acctacagtt tatgtataca gttgattttg atgtatttat aaaagctttt ttttctagat     3600

ttgacatttt tctgtatcat tttactgtat ttttgcatgg ttccttgtat tgcatttctt     3660

tgcacatatt atgggcttgt gaccctaaac ttgcaggcaa ggttagctgc tttagtaagt     3720

agaattttgt ggtctttttg ttttttacat agtaccaagc cttgataatt atgaattttt     3780

tatccattac taacctttaa tttaatcaat catgtacttt agtttaatgt ataaagatcc     3840

tctagaaaat gataatattg tgtattaaga cattccttaa ttaggacaaa atggctgctg     3900

tatatttact atatggagtt ctgagttaaa taccatcctt aatactggga acagaataca     3960

acccatataa atcagatgca ggtggtagtc acatcaccag agtgatcagt ataaattttc     4020

ttggtgtatc cttttccttt caacacagtg cagataagag ttgaatattg atatcataca     4080

tttagactgc tgttctgatt gcatttatct ttttcctaca tcatttagaa ttttatttcc     4140

ctgattcagt ttttgctgct gtgaaacagc tctgatgaac actaaatatt aatttcaatt     4200

agctagattg tacatacttg cagatttaac aaaattttag ggaaattgaa aaagacatgt     4260

agaatttgtt gtcttctgct aagcacgaaa agttaagata tctgcttaca ttgattttgt     4320

agacacatta agtcaagatt tggaatttaa gtcactggca ggtatctgtg cattcataga     4380

acttataaag gtcccaggat cacttttaag ggatttttat tagtttaaag gtaaataaag     4440

tcagctgaat ctacatgtct cttgttttat ttctctctaa acttgaaaac agtaaatctg     4500

cagatactgt gaggcacaaa ttatactgtc aacctactgt tgctatggtt atatactccc     4560

acttcataca ttaccaagag tcgatcactg atttaaaatt tttaatttct atagttaaga     4620

tttactgcat aatatagaat ataaagttaa gttaacatac taacatttct cctttggagg     4680

aagttttaat ctacttcagg atgcatatta ttatcaagat actttcatat acaggatagc     4740

ctaattttat ttgtttaaat atgcttaata tgccccagat tgcaaatgca tccagtcagt     4800

aatatcactg tctgtatgtg gaggacatgt tcccatggat catatgtgaa gatgtcaata     4860

agcttgcatt aagccacctg ctttgtaagt ggattgatta ataaataact tatatttcta     4920

ttgtctttgt gtttcataat tagtttttat aaaaacagtt tacattaaac atcttggaat     4980

tcaacaatag tgatctcact caaattgaca tttgcataat ttgacattta tattcattca     5040

gttatgacta cttgcccttt tcttcatatt agtaaatgtt acactgtagt agttgtcaat     5100

gttaacaggc ttcaacatag tatgtgtgca gatggacgat ggatttaaag agcatacctt     5160

atgattaaac cgaggttata gaaggtcagg ggagagtgaa ggagtcagtg acctatgtct     5220

gccatcttac tggggaaaag agcaagtagc ctgtcttcct ttaagtaagt agcctgtaat     5280

ggatgtacta ctttgccact ggaatacccc gggtctgtgc caagggactg aagaagtgta     5340

agatggggag aactgtatgt catggagtcc tcttgacgtt cccccagata caagtaaagc     5400

acaggtggat ttctctattt ttgaatacta catcagattt agatgcacga ctacctgttg     5460

acttgtttta taattgctac tgattttttt aatgtaggca aagctttgtt actttgaaat     5520

ttatttaata aaagtatttg tgacataaac ctgaattgtt aatataggag cttattaagc     5580

tactgccatt agttatcgaa aaatgtgata agtaatgaag aaagtaagga agaaaatgac     5640

tttgaacatt ttgacttttt gtgctttgtt ttggtgtctt ccatatcctg ctgcatctta     5700

tatgtcaaaa tgaacatttc agtggtagct gtccaaatac ataaaaacta aaattctttt     5760

gttagcaagt ccttattttt attgttgtta acatgcaagt gataaactga taatttgaaa     5820

catttttctt actctggtga ctttctttta gctgctagca cacttcagca tttgaaccat     5880

aacagttgtg ataaactgat cgtttgaaac gtt                                  5913


<210> 1297
<211> 455
<212> DNA
<213> Homo sapiens

<400> 1297
cttcctcttt ccctcggagc gggcggcggc gttggcggct tgtgcagcaa tggccaagat       60

caaggctcga gatcttcgcg ggaagaagaa ggaggagctg ctgaaacagc tggacgacct      120

gaaggtggag ctgtcccagc tgcgcgtcgc caaagtgaca ggcggtgcgg cctccaagct      180

ctctaagatc cgagtcgtcc ggaaatccat tgcccgtgtt ctcacagtta ttaaccagac      240

tcagaaagaa aacctcagga aattctacaa gggcaagaag tacaagcccc tggacctgcg      300

gcctaagaag acacgtgcca tgcgccgccg gctcaacaag cacgaggaga acctgaagac      360

caagaagcag cagcggaagg agcggctgta cccgctgcgg aagtacgcgg tcaaggcctg      420

aggggcgcat tgtcaataaa gcacagctgg ctgag                                 455


<210> 1298
<211> 2502
<212> DNA
<213> Homo sapiens

<400> 1298
cgctttgggg ttctgtgtgc agcgagcatg gtgtccttgg caccagggtt tcggcagagg       60

agcctagcgt gggcctactt ggactcctcc gcgtggggca gctcgggaca cccgggcctg      120

caggagagcg gggttctagg ctggccccgg ctctgcagtg cagccgggtg cctgccactc      180

gcggggctct gtcgcagtac tcgtgcctgg cgcctcccct cagccacaga gaccgcagta      240

gctccaacca tcgcacccct aactgggcca cgagttctct gattgccaga cctgttgtct      300

ttgccactca ctgttctgag taattggaga gtcgtgtatt cactacacgc caaccagagt      360

ggtcctgtaa aagcgtaagc ctagtgtaga tacgcttctg cttaaaactc ttgagtggct      420

cccagtgctt ttagaacaaa atccaaacgc ctttccgaag tcgacaaggc ccagcttgat      480

tgagcagaag atgtgatagg agatgaggag cggggggctt ctgcaaaagt gcttcggtcg      540

ctcaggcttt tggcacattt tgcttatgca acctagttct ttctacctta gggccttttc      600

ttgggaaagt tgggagtctc actctgctgc ctaggctgag tgcagtggtg tgatcgaggc      660

gcactgcagc cttgacctcc tgggctcaag cgatcctcac ctcggcctac cgagtagctg      720

ggactacagg cacgcgccac tacactcgga tttctgacag tcagacttgt ccacaagaac      780

tcaactggca aggctgcttt tctgtgctaa aactggggag ctagtgggca ccatgaagat      840

cttctgcagt cgggccaatc cgaccacggg gtctgtggag tggctggagg aggatgaaca      900

ctatgattac caccaggaga ttgcaaggtc atcttatgca gatatgctac atgacaaaga      960

cagaaatgta aaatactacc aaggtatccg ggctgccgtg agcagggtga aggacagagg     1020

acagaaggcc ttggttctcg acattggcac tggcacggga ctcttgtcaa tgatggcggt     1080

cacagcaggt gccgacttct gctatgccat cgaggaaaat tgtgaggccg tgccccacag     1140

agccaccgtc tatgcacagc tggtggagtc cgggaggatg tggtcgtgga acaagctatt     1200

tcccatccac gtgcagacca gcctcggaga gcaggtcatc gtccctcccg ttgacgtgga     1260

gagctgccct ggcgcaccct ctgtctgtga cattcagctg aaccaggtgt caccagccga     1320

ctttacagtc ctcagcgatg tgctgcccat gttcagcata gacttcagca agcaagtcag     1380

tagctcagca gcctgccata gcaggcggtt tgaacctctg acatctggcc gagctcaggt     1440

ggttctctcg tggtgggaca ttgaaatgga ccctgagggg aagatcaagt gcaccatggc     1500

ccccttctgg gcacactcag acccagagga gatgcagtgg cgggaccact ggatgcagtg     1560

tgtgtacttc ctgccacaag aggagcctgt ggtgcagggc tcagcgctct atctggtagc     1620

ccaccacgat gactactgcg tatggtacag cctgcagagg accagccctg aaaagaatga     1680

gagagtccgc cagatgcgcc ccgtgtgtga ctgccaggct cacctgctct ggaaccggcc     1740

tcggtttgga gagatcaatg accaggacag aactgatcga tacgtccagg ctctgaggac     1800

cgtctctctc ctcctgggcg agccgttctt cactaccagc ctgctgccgt ggcacaacct     1860

ctacttctgg tacgtgcgga ccgctgtgga ccagcacctg gggccaggtg ccatggtgat     1920

gccccaggca gcctcgctgc acgctgtggt tgtggagttc agggacctgt ggcggatccg     1980

gagcccctgt ggtgactgcg aaggcttcga cgtgcacatc atggacgaca tgattaagcg     2040

tgccctggac ttcagggaga gcagggaagc tgagccccac ccgctgtggg agtacccatg     2100

ccgcagcctc tccgagccct ggcagatcct gacctttgac ttccagcagc cggtgcccct     2160

gcagcccctg tgtgccgagg gcaccgtgga gctcagaagg cccgggcaga gccacgcagc     2220

ggtgctatgg atggagtacc acctgacccc ggagtgcacg ctcagcactg gcctcctgga     2280

gcctgcagac cccgaggggg gctgctgctg gaacccccac tgcaagcagg ccgtctactt     2340

cttcagccct gccccagatc ccagagcact gctgggtggc ccacggactg tcagctatgc     2400

agtggagttt caccccgaca caggcgacat catcatggag ttcaggcatg cagatacccc     2460

agactgacca ctcttgagca ataaagtggc ctgagggctg gg                        2502


<210> 1299
<211> 1887
<212> DNA
<213> Homo sapiens

<400> 1299
tcctctccta ttatgcaaac ccacaccatg gatccagcag actactctgg ccccagcatg       60

ctgctccttg ggatgatggg agaaggggga aacctgtgtt ttctcttggt tttagggtat      120

gggtctactt ctttgaacat tcgctcagat cgtaaggtaa ccccaagaat cggcatcact      180

ctctggtctg ggcgcctgga tagtcacgca tggagtccgc gaggtgctgg cgccggagca      240

cgctgggaac gccgggctcc cggccggcct gacccggaag ggctggcgca tggtaacccc      300

agcttcccta gcaaccaagc aggcgcaaga agcaaccagc cgcgctatcc gctcccgttg      360

ctaccggaat gcctcttcag gttagcgatt acagctggca gcagacgaag actgcggtct      420

ttctgtctct gcccctcaaa ggcgtgtgcg tcagagacac ggacgtgttc tgcacggaaa      480

actatctgaa ggtcaacttt cctccatttt tatttgaggc atttctttat gctcccatag      540

acgatgagag cagcaaagca aagattggga atgacaccat tgtcttcacc ttgtataaaa      600

aagaagcggc catgtgggag accctttctg tgacgggtgt tgacaaagag atgatgcaaa      660

gaattagaga aaaatctatt ttacaagcac aagagagagc aaaagaagct acagaagcaa      720

aagctgcagc aaagcgggaa gatcaaaaat acgcactaag tgtcatgatg aagattgaag      780

aagaagagag gaaaaaaata gaagatatga aagaaaatga acggataaaa gccactaaag      840

cattggaagc ctggaaagaa tatcaaagaa aagctgagga gcaaaaaaaa attcagagag      900

aagagaaatt atgtcaaaaa gaaaagcaaa ttaaagaaga aagaaaaaaa ataaaatata      960

agagtcttac tagaaatttg gcatctagaa atcttgctcc aaaagggaga aattcagaaa     1020

atatatttac tgagaagtta aaggaagaca gtattcctgc tcctcgctct gttggcagta     1080

ttaaaatcaa ctttacccct cgagtattcc caacagctct tcgtgaatca caagtagcag     1140

aagaggagga gtggctacac aaacaagctg aggcacgaag agcaatgaat actgacatag     1200

ctgaactttg cgatttaaaa gaagaagaaa agaacccaga atggttgaag gataaaggaa     1260

acaaattgtt tgcaacggaa aactatttgg cagctatcaa tgcatataat ttagccataa     1320

gactaaataa taagatgcca ctattgtatt tgaaccgggc tgcttgccac ctaaaactaa     1380

aaaacttaca caaggctatt gaagattctt ctaaggccta caggattatg aagcggcact     1440

taagattgat ccatccaaca aaattgtaca aattgatgct gagaagattc ggaatgtaat     1500

tcaaggaaca gaactaaaat cttaatgact attagaagta actaagtatt gttataagtt     1560

ttttaaaaac aactggaggc atctttgtac atattatggc cagttgtaca gaatcgcttt     1620

ctgtttagta ctttagttct gttgagggca aaatattata aatctataga aaataaactg     1680

tttgacttga atcatttctg aataagtaaa tctaaataag aatctatttt aattccttat     1740

ttcttcatat taatacatat gtatactttt ttgtgttact gaattaagct tgcccttgta     1800

acaaaatatg ttttggtata gttaccagga cacttactga ttaattttta acaaggtaga     1860

attttaaaat aaaagattta taaataa                                         1887


<210> 1300
<211> 5083
<212> DNA
<213> Homo sapiens

<400> 1300
atgtggtcat tgacggccag tgagggcgag agtaccacgg cccacttctt ccttggagct       60

ggagatgagg ggctgggcac ccgtggaata ggcatgaggc cagaagagag tgacagcgag      120

ctccttgagg atgaggagga tgaagtgcct cctgaacctc agatcattgt tggcatctgt      180

gccatgacca agaaatccaa gtccaagcca atgactcaaa tcctagagcg actctgcaga      240

tttgactacc tgactgttgt cattctggga gaagatgtaa tccttaatga acctgtggaa      300

aactggccat cctgccactg cctcatctct ttccactcca aaggctttcc tctggacaaa      360

gctgttgctt actccaagct tcgaaacccc tttcttatca atgatctggc catgcagtat      420

tacatccaag ataggaggga ggtgtaccgg atcctgcagg aagagggtat tgatctgcct      480

cgatatgctg tgctcaaccg tgatcctgcc cggcctgagg aatgcaacct gatagaaggt      540

gaagaccaag tagaggtcaa tggagctgtc tttcccaagc cctttgtgga gaagccagtg      600

agtgcagaag accacaatgt ttacatctac taccccagct cagctggagg aggaagccag      660

cgtctctttc gtaagattgg cagccgaagc agtgtttact ctcctgagag cagcgtccga      720

aagacggggt cgtacatcta tgaggagttt atgccaacag atggcacaga tgtcaaggtg      780

tatacagtgg ggccagatta tgcccatgct gaagctagaa aatctccagc tttggatggg      840

aaggttgaac gagacagtga ggggaaagag attcgatatc cagtcatgct gactgccatg      900

gaaaagctgg tggccaggaa agtctgcgta gctttcaagc aaacagtttg tggatttgac      960

cttcttcgtg ccaatggtca ttcctttgtg tgtgatgtca atggctttag ttttgtcaag     1020

aactcgatga aatactacga tgactgtgcc aagattctgg ggaacaccat aatgcgggag     1080

cttgccccac agttccagat tccatggtcc atccccacgg aggctgagga cattcccatt     1140

gttcccacca catctggcac tatgatggaa cttcgttgtg tcattgcaat tattcgtcat     1200

ggggatcgta ctcccaagca gaagatgaag atggaagtga aacacccaag gttttttgct     1260

ctgtttgaaa aacatggtgg ctacaagaca gggaaattaa aactcaagcg acctgagcag     1320

ctccaggagg tgctggatat cacaaggctg ttgttggctg aactggagaa agaaccaggt     1380

ggtgagatcg aggagaagac tggaaaacta gagcagctga agtctgtact ggagatgtat     1440

ggtcacttct caggtataaa ccggaaggta caattgactt actaccctca tggagtaaaa     1500

gcttctaatg aggggcaaga tccacagagg gaaactctgg ccccatctct gttgctggta     1560

ctgaagtggg gtggagaact gactcctgct ggccgtgttc aggctgagga gctggggcga     1620

gcttttcgct gcatgtaccc tggaggacag ggtgactatg ctggcttccc tggttgtggg     1680

ctgcttcgtc tccatagcac tttccgccac gatctcaaga tctatgcctc tgatgagggt     1740

cgtgttcaga tgactgctgc tgccttcgcc aagggccttc tggctctaga aggggagctg     1800

acacccattt tggtgcaaat ggtgaagagt gccaacatga atgggctact ggacagcgat     1860

ggggattcct tgagcagctg ccagcaccgg gtgaaggctc ggctgcacca tattctacag     1920

caggatgcgc cctttggccc tgaggactac gatcagctgg ctcccaccag aagtacttcc     1980

ctgctcaact ccatgactat catccagaat cctgtgaagg tctgtgatca ggtatttgcc     2040

ctgatcgaaa acctcaccca ccagatccgg gaacgaatgc aggaccccag gtctgtagac     2100

ctgcagctct accacagtga gacactagag ctaatgctac agcgttggag caagctggag     2160

cgtgactttc gacagaagag tgggcgctat gatatcagta agatccctga catctatgac     2220

tgtgtcaagt atgatgtgca gcacaatggg agtctgggac ttcaaggcac agcagagttg     2280

ctccgtctct ctaaggcact ggctgatgtg gtcattcccc aggagtacgg gatcagtcgg     2340

gaggagaaac tggaaattgc tgtgggcttc tgtcttccac tgttgcggaa gatactactt     2400

gacctgcaga gaacccacga ggatgagtct gtcaacaagc tgcatcccct gtactcccga     2460

ggcgtgctct ccccaggtcg ccacgttcga acgcgtctct atttcaccag tgagagccat     2520

gtccactccc tgctcagtgt cttccgttat ggaggacttc ttgatgagac ccaggatgca     2580

caatggcagc gagctttgga ttatcttagt gccatctcag agcttaacta catgacccag     2640

attgtcatca tgctttatga ggacaacaca caggatccct tatcagagga acggttccat     2700

gtggagctac acttcagccc cggagtgaaa ggtgttgagg aagaaggcag tgccccggct     2760

ggctgtggat tccgtccagc ctcttctgag aatgaggaga tgaaaaccaa ccaaggcagt     2820

atggagaacc tgtgtccagg aaaggcatca gatgaaccag accgggcatt gcagacttca     2880

ccccagcctc ctgagggccc tggccttccg aggagatcac ccctcattcg taaccgaaaa     2940

gctggttcca tggaggtact ttctgagact tcatcctcga ggcctggtgg ctaccggctc     3000

ttttcatctt cacggccacc cacagaaatg aagcagagtg gcctagggtt tgaagggtgt     3060

tccatggtgc ctaccatcta ccctctggaa acactgcata atgccctttc cctacgtcaa     3120

gtgagtgaat tcttgagtag agtctgccag cgccacactg atgcccaggc acaggcatct     3180

gcagccctct ttgattccat gcacagcagc caggcctcag ataacccatt ttctccacca     3240

cgtactcttc attcacctcc cctgcaactc cagcagcgct ctgagaagcc cccttggtta     3300

gagacaaggt tttgccatgt tggccaggct ggtttagagc tcctgacctc aagtgatctg     3360

cctgcctcgg cctcccaaag tgctgggatt acaggcgtga gccaccgcac ccagccagac     3420

agcagtggcc cttctagcac tgtgtccagt gctggtcctt cttcccctac tacagtagat     3480

ggtaactccc aatttggctt cagtgatcaa ccctccctaa attcacacgt ggctgaagaa     3540

catcaaggcc ttgggctgct ccaggagacc cctgggagtg gagcacaaga gctctccata     3600

gaaggggagc aagagctttt tgaaccaaat cagtccccac aggtgccacc tatggaaacc     3660

agccagccat acgaggaggt cagccagcca tgtcaggagg tccctgacat cagccagcca     3720

tgccaggaca tttctgaggc gctcagccag ccatgtcaga aggtccctga catcagccag     3780

caatgccagg agaaccatga caatggtaac cacacatgcc aggaggtccc tcacatcagc     3840

cagccatgcc agaagtccag ccaactgtgc cagaaagtct ctgaggaagt ttgccagcta     3900

tgtctggaga actccgagga ggtcagccag ccatgccagg gggtctctgt ggaggttggc     3960

aagctggtcc ataagttcca tgtaggggtt ggtagcttgg tccaggaaac ccttgtagaa     4020

gttggcagcc cagctgaaga gatccctgag gaggtcatcc agccatacca ggagttctct     4080

gtggaggttg gcaggctggc ccaggagact tctgcgatca atctgttatc tcagggcatc     4140

cctgagattg ataaaccatc ccaagagttc cctgaggaga ttgatctgca ggcccaggag     4200

gtccctgagg agataaatta gaagtcctgg gtggtccctg aagtgattga tcagctgcct     4260

ggagagggta ttcctcaagc ccagcatcca tctggtgatc caaaccctca gagccagtct     4320

ctagcccatg accagcactc accccttcca ccagcaacat gtgattaatt ttctcattag     4380

tggtatcaca ctataccagc catttgagcc agcaaccttt tctgttggct aactcactgg     4440

ccagctctca ccagcggtgt ctggggaagt agttctcttt gtatgaagca tacctgtgcc     4500

agagctgtgg ttgaggagga gccagtttta ggttcgaaga agccattggc tcctcactta     4560

gccattagac ttgaatagga tttccttggg gtgggttggt ctgtcattac ccagccttct     4620

ctgagcatcc taggaaatca cagattgtta aaggaaatgc cgcttcactg ctgaagacac     4680

catctggcga cagcaaatgc aaaagagggg actctagggt cttcactttt ctggggaaat     4740

gttcacgact tctcaaggta cgcttagacc atatgtgcat tcaggggact cttgtctttg     4800

ccagcactcc tcaggtgagc ccgggatggc tatctgaaat gtctggaaaa tagagtccct     4860

tccccaaaca tctgacatgg ccactaaatc tttagacttg ccttatagat ccttccatat     4920

catccccaag tgccccttct gcctcagtcc tgttcctctg ggcaatagct ctagggaaaa     4980

gtaggtatta gactgctgtg caaaattcag agcaactact taaaatgctc tagaggattc     5040

ttagccagtc tgtgaaagtg ggcctcctct gtggtggggc tgt                       5083


<210> 1301
<211> 2783
<212> DNA
<213> Homo sapiens

<400> 1301
gaaggggcgg agctccgcct acgaaggctg agcatcgccg caagaggcgg agtctggagc       60

gaggcggagc tctcctaggg gcggggaaaa tggggcgggg cctccggaca gggggcggag      120

cgtggctgtt cgcgctcatc cccctccccc ggccctgggt gtccccgtga cgaggcagcg      180

cggagccgcc gcgggccggg cccatcccgc cgcagcggcc cggggccgag caggggctag      240

gcggggaggg agcggcgccc agcggggccc ggagcgtggc cagaatggtg ctggaaggaa      300

accctgaagt ggggtccccc cgaacctcag acctccagca ccgggggaac aagggctctt      360

gcgttctctc ctctcccggt gaagatgcgc agccaggcga ggagcccatc aagtatggtg      420

aactcatcgt cctgggctac aatggttgtc tggcaagtgg ggacaagggc cgccggcgaa      480

gccgcctggc actgagccgc cggtcgcacg ccaacggggt gaagccagac gtcatgcacc      540

acatctccac gccgctcgtc tccaaggcac tgagtaaccg tggtcagcac agcatctcgt      600

atacactgtc ccggagccac tcggtcatag tggagtatac acatgatagc gacacagaca      660

tgttccagat tggccgctcc acagagaaca tgattgactt cgtggtaaca gacacgtccc      720

ctggaggagg ggctgccgag ggcccttctg cccagagcac catctcccgc tatgcctgcc      780

gcatcctctg tgaccgccgg ccaccctata ctgcccgcat ctatgccgct ggcttcgatg      840

cctctagcaa catcttcctt ggagagcgag cggccaaatg gcggacccca gatggcctga      900

tggatggact gaccaccaat ggagtcctgg tgatgcaccc ggcaggcggc ttctccgagg      960

actcagcccc gggtgtctgg cgggagatct cggtctgtgg gaatgtgtac acattgcggg     1020

acagccgctc agcccagcag cggggcaagc tggtggaaaa cgagtccaac gtgctgcagg     1080

acggctctct catcgacctg tgtggggcca cactgctgtg gcgcacaccg gcggggctgc     1140

tgcgggctcc cacactgaag caactggagg cccagcggca ggaggcaaat gcagcgcggc     1200

cccagtgccc cgtgggcctc agcactctgg ccttccccag cccagcccgt ggccgcacag     1260

cgcccgacaa acagcagccc tgggtctacg tccgctgcgg gcacgtccat ggctaccacg     1320

gctggggctg ccggcgggag cggggccccc aggagcgcga atgtcctctc tgccgccttg     1380

tggggcctta tgtgcctcta tggcttggcc aggaggccgg cctctgcctg gaccctgggc     1440

cgcctagcca tgcctttgca ccttgcggcc acgtctgctc tgagaagact gcccgctact     1500

gggcccagac accactgccc cacggcaccc atgctttcca tgccgcctgc cccttttgcg     1560

gggcctggct taccggcgag catggctgcg tccgcctcat tttccagggc ccgctggatt     1620

aggctccctg gggccccctg ctgctgtgcc cacctgccca cccaggtccc cacctcctgc     1680

agcccagagg gagctctgca tgtgggacac tccctgctgg cacagccaca ccagatggac     1740

atgttggatg ggctgtgccc ttccccccaa ctgtggcccc ccaaggaggt ccccaagatc     1800

tccaccccag tcatgctgat ggggccttca gcaccagctc tgtcctgggt cgatggagga     1860

aagcccagcc ccatggcctt gcccttcctg gggcatccca catcgtgccg ccgacactgt     1920

gtgcccctgg gggagtgaag gggccagggg cctttgaccc ccagcttagg ctggctatgc     1980

cctgagcctg ccaacccagt ttcagacact catccttcat ccttcctgct gccgccctgg     2040

gttcctctat aaacctcgct gctcagctgc ccccacaagt cccacatgcc ccgcatgcgt     2100

gcaatgcctc cagcccccaa gtgagtggtg ggtgggtggc aggctgggcc tagcacttgc     2160

tgatagccac tatgggctcg actctgtgct aagtggtatc tggggacaca gaggcaatca     2220

gacctggttc cccccctggt ggagttcaca gtctagtgga ggacagactg ttaacaaatg     2280

gcaacacggc ttcatgcgtg ccaggatcag agtacaaatc aggctgtggc aggcctcact     2340

ggtaatggaa aagtgaggga ggcttcacgg aggaggtgtc ataggagctc agcctcaacg     2400

gctgctcgga accctccgag tccacaagat gggaagcaag tccacaagat gggaagcgtg     2460

ctctatacag aagggagggc ctgtgcacag gctcaggtgt cagtaagcca gaaatccagg     2520

gacagagtca ggatggctgg agcatggact gcggggggaa cagagaaggg ggtggagcaa     2580

aaggttggga ccatgtgacc agggaagatg ctggatggag gattctgaac ctcatttgtg     2640

gacggtcagg agtcaacaaa gggaggagag aggactcact ggtcaagagt gtcggctgtg     2700

acacaagggc catcatccct gaatgcccac catgtgcccc gcactgtgct gatgatgata     2760

ataataacta cgtccattga gca                                             2783


<210> 1302
<211> 1950
<212> DNA
<213> Homo sapiens

<400> 1302
atggggaccg cgcttgtgta ccatgaggac atgacggcca cccggctgct ctgggacgac       60

cccgagtgcg agatcgagcg tcctgagcgc ctgaccgcag ccctggatcg cctgcggcag      120

cgcggcctgg aacagaggtg tctgcggttg tcagcccgcg aggcctcgga agaggagctg      180

ggcctggtgc acagcccaga gtatgtatcc ctggtcaggg agacccaggt cctaggcaag      240

gaggagctgc aggcgctgtc cggacagttc gacgccatct acttccaccc gagtaccttt      300

cactgcgcgc ggctggccgc aggggctgga ctgcagctgg tggacgctgt gctcactgga      360

gctgtgcaaa atgggcttgc cctggtgagg cctcccgggc accatggcca gagggcggct      420

gccaacgggt tctgtgtgtt caacaacgtg gccatagcag ctgcacatgc caagcagaaa      480

cacgggctac acaggatcct cgtcgtggac tgggatgtgc accatggcca ggggatccag      540

tatctctttg aggatgaccc cagcgtcctt tacttctcct ggcaccgcta tgagcatggg      600

cgcttctggc ctttcctgcg agagtcagat gcagacgcag tggggcgggg acagggcctc      660

ggcttcactg tcaacctgcc ctggaaccag gttgggatgg gaaacgctga ctacgtggct      720

gccttcctgc acctgctgct cccactggcc tttgaggggc aaatgcaggc cacgccagag      780

tgcttcgccc acctcacaca gctgctgcag gtgctggccg gcggccgggt ctgtgccgtg      840

ctggagggcg gctaccacct ggagtcactg gcggagtcag tgtgcatgac agtacagacg      900

ctgctgggtg acccggcccc acccctgtca gggccaatgg cgccatgtca gagtgcccta      960

gagtccatcc agagtgcccg tgctgcccag gccccgcact ggaagagcct ccagcagcaa     1020

gatgtgaccg ctgtgccgat gagccccagc agccactccc cagaggggag gcctccacct     1080

ctgctgcctg ggggtccagt gtgtaaggca gctgcatctg caccgagctc cctcctggac     1140

cagccgtgcc tctgccccgc accctctgtc cgcaccgctg ttgccctgac aacgccggat     1200

atcacattgg ttctgccccc tgacgtcatc caacaggaag cgtcagccct gagggaggag     1260

acagaagcct gggccaggcc acacgagtcc ctggcccggg aggaggccct cactgcactt     1320

gggaagctcc tgtacctctt agatgggatg ctggatgggc aggtgaacag tggtatagca     1380

gccactccag cctctgctgc agcagccacc ctggatgtgg ctgttcggag aggcctgtcc     1440

cacggagccc agaggctgct gtgcgtggcc ctgggacagc tggaccggcc tccagacctc     1500

gcccatgacg ggaggagtct gtggctgaac atcaggggca aggaggcggc tgccctatcc     1560

atgttccatg tctccacgcc actgccagtg atgaccggtg gtttcctgag ctgcatcttg     1620

ggcttggtgc tgcccctggc ctatggcttc cagcctgacc tggtgctggt ggcgctgggg     1680

cctggccatg gcctgcaggg cccccacgct gcactcctgg ctgcaatgct tcgggggctg     1740

gcagggggcc gagtcctggc cctcctggag gagaactcca caccccagct agcagggatc     1800

ctggcccggg tgctgaatgg agaggcacct cctagcctag gcccttcctc tgtggcctcc     1860

ccagaggacg tccaggccct gatgtacctg agagggcagc tggagcctca gtggaagatg     1920

ttgcagtgcc atcctcacct ggtggcttga                                      1950


<210> 1303
<211> 2544
<212> DNA
<213> Homo sapiens

<400> 1303
ggcgacgggt cggcggagac agaaaagcgc cggacgccgg ggtgatcatg gacgcttgac       60

aacctgcggg caggcgccgg gaggccgagc cagcgactaa gaggaccgag aggtggcgtg      120

gacagatttc aaggccagag aatggcaggg gaacagaaac cctcaagtaa tctcctggag      180

cagtttattt tactagccaa aggtaccagt ggctcagccc tcactgctct cataagccag      240

gtcttagagg ctcccggagt gtatgtcttt ggagaacttc tggagctggc caacgtgcag      300

gagcttgcgg aaggagctaa tgctgcttat ttgcagttgt tgaacctgtt tgcctatggg      360

acatacccag attacatagc caacaaggag agcctgccag aactgagcac agctcagcag      420

aacaagctga agcatcttac catcgtgagc ttggcatcaa gaatgaagtg tatcccctac      480

tccgtgttgc tgaaagacct ggagatgcgg aatctccggg aactagaaga ccttatcatt      540

gaggctgtct acactgacat catccagggc aagctggacc agcgaaacca gctgctggaa      600

gtggatttct gcattggccg tgacatccga aagaaggata tcaataatat tgtcaagacc      660

ctgcatgaat ggtgtgatgg ctgtgaagca gttctactgg gcatcgagca gcaagttctg      720

agagccaacc agtacaaaga gaaccacaac cgaactcagc agcaggtaga agcagaggtt      780

accaacatca agaagacact caaagccacc gcatcctcct cggctcagga gatggagcag      840

cagctggctg aacgggagtg tccccctcac gctgagcaga ggcagcccac caagaagatg      900

tccaaagtga aaggtctggt ctccagccgc cactagggcc ggctggggca gctggcactc      960

accaggcctg ggtcaggtgg ggaggggaca ccaagggccc atttcctccc ctctctacct     1020

gcagtgagtt ccagacctgc ccgtcccctc accagcgcct ccccaccctg ttggtactgt     1080

tccagaaaaa ctgttactcc ccctcaccca ctccctcctt ccccagttgt tcccttcaga     1140

ctcaggggct ccaccaatgc catcccaaaa cagggtcaga cactgcccag cttccctcca     1200

ggaggttctt gtctctgtgt aagggcttgt ctccctccca gtttttcttt tgctccacgt     1260

cattttgtca ggctggttat aagccggagg cagctttaac cagcccccag ggatgattgt     1320

gaaggaggcc cctccccttg tgaggagggg gcactcctct ccagcccctg gtaccacagt     1380

cctcacgatg gtgcagtgat ttctagccag gcgtcaagat gcgctgcttt ccctctcctg     1440

cctcatccct tgttggcagc tccagttcag gccgtggagg gacgtgatgc tgggctgtgt     1500

ttactaaacc cacgggtttt cagcctctta agcccagctc cgatctccaa ttagttgaga     1560

gcgctgggtt gactaacctc tggtatctga gcacagacag agggtgctgt gggtctgctg     1620

ggtggcagaa atggttcctt ccggcttggc gttctctcct ggccactctt cctgctgcct     1680

ctgactactc agccttgttt tcggtgtgta ggccccagct gcccactgga actgccggct     1740

aatgcttgct ctcccaagat ctttaactcc tcctggctgc acctgggtag ggatggtggc     1800

atcgatgccc ctctgtctgc tgaaggacct gttgctgctt ctgtcttttc acccctcctt     1860

ggctgatgac ccagagccct ctgatgatgg cattctcctg gcaagagaaa aagacttaac     1920

tagacttctg aacttgaaca gtttcaggtt atattttaat tttttttttt ttgtacaggt     1980

tctgattcta atacatttca acatgctttt gtcccccctc gtgtcaatat ttgttataga     2040

ctaatcgccg gggatttttc acctggttgg agggtggggg tggggtgggg tgtgtgtgtg     2100

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtttgtagg tcctggactg attaaagttc     2160

attgaggaaa aagcacattt tacaacaaaa aaataaaagt gtagatttaa tgtatgtgac     2220

tggggtttgg ggttgcatac ctggtggatc ttgaggggct gggattaggg tggttcagga     2280

aaatgtgatg ctgtttcccc atgtttagcc atggtcaaaa aatggatttc tcctttttct     2340

aaaatgtcca gcaactgcct actgttgatc aaatgttgaa gtattcttgt ttccctttta     2400

agccaatcca tgtgcccaca taacattatg cccaagtgga gagttcactt taatttccaa     2460

agtatgtttc atgcagcccc ctgtcagctg ctctgtggaa aaggggttct gttatgaaat     2520

aaatgttgca ctccctgcat ccca                                            2544


<210> 1304
<211> 1177
<212> DNA
<213> Homo sapiens

<400> 1304
tcctgtcact ggcttatatg gacacgtcag cccaccgtca cgtgaccgca ggctgctaaa       60

aacagctcca gcacccactc caaaccaggg cctgaaacaa tgtcctccac cgagagaaac      120

gtaaaggaca cttgatcaca caatccctgg aataatatcc aggaaacact tgctggagcc      180

actcgcagca cccttccctg gcagcacact tggggacagc gaggagatga gcgcatctct      240

gaattacaaa tctttttcca aagagcagca gaccatggat aacttagaga agcaactcat      300

ctgtcccatc tgcttagaga tgttcacgaa acctgtggtg attctccctt gtcagcacaa      360

cctgtgtagg aaatgtgcca gtgatatttt ccaggcctct aacccgtatt tgcccacaag      420

aggaggtacc accatggcat cagggggccg attccgctgc ccatcctgta gacatgaagt      480

ggttttggat agacatgggg tatatggact tcagaggaac ctgctggtgg aaaatatcat      540

tgacatctac aagcaggagt ccaccaggcc agaaaagaaa tccgaccagc ccatgtgcga      600

ggaacatgaa gaggagcgca tcaacatcta ctgtctgaac tgcgaagtac ccacctgctc      660

tctgtgcaag gtgtttggtg cacacaaaga ctgccaggtg gctcccctca ctcatgtgtt      720

ccagagacag aagtctgagc tcagtgatgg catcgccatc ctcgtgggca gcaacgatcg      780

agtccaggga gtgatcagcc agctggaaga cacctgcaaa actatcgaga ttggatttga      840

ggctcctccc ctccagggac aggctgcagc tccagcgagt ggcagtggag ctgattctga      900

gccagctcgc catatcttct ccttttcctg gttgaactcc ctaaatgaat gatattcatt      960

ccaactgctg cccctctgtc tgcctggctg agatgcatgt gggcagcagg aagcccaagt     1020

gaaattaata ttatgcagat gatgaaaggg acctctgaac aggatttctg caaaaatagc     1080

cccaaactgc aattccatat gacttatcta acatcttggg gggaaagaat attttgagaa     1140

aatagttgca gaaagcactg gaaataataa acttgat                              1177


<210> 1305
<211> 3654
<212> DNA
<213> Homo sapiens

<400> 1305
ctggtctgcg gctgagatac acagagcgac agagacattt attgttattt gttttttggt       60

ggcaaaaagg gaaaatggcg aacgactccc ctgcaaaaag tctggtggac atcgacctct      120

cctccctgcg ggatcctgct gggatttttg agctggtgga agtggttgga aatggcacct      180

atggacaagt ctataagggt cgacatgtta aaacgggtca gttggcagcc atcaaagtta      240

tggatgtcac tgaggatgaa gaggaagaaa tcaaactgga gataaatatg ctaaagaaat      300

actctcatca cagaaacatt gcaacatatt atggtgcttt catcaaaaag agccctccag      360

gacatgatga ccaactctgg cttgttatgg agttctgtgg ggctgggtcc attacagacc      420

ttgtgaagaa caccaaaggg aacacactca aagaagactg gatcgcttac atctccagag      480

aaatcctgag gggactggca catcttcaca ttcatcatgt gattcaccgg gatatcaagg      540

gccagaatgt gttgctgact gagaatgcag aggtgaaact tgttgacttt ggtgtgagtg      600

ctcagctgga caggactgtg gggcggagaa atacgttcat aggcactccc tactggatgg      660

ctcctgaggt catcgcctgt gatgagaacc cagatgccac ctatgattac agaagtgatc      720

tttggtcttg tggcattaca gccattgaga tggcagaagg tgctccccct ctctgtgaca      780

tgcatccaat gagagcactg tttctcattc ccagaaaccc tcctccccgg ctgaagtcaa      840

aaaaatggtc gaagaagttt tttagtttta tagaagggtg cctggtgaag aattacatgc      900

agcggccctc tacagagcag cttttgaaac atccttttat aagggatcag ccaaatgaaa      960

ggcaagttag aatccagctt aaggatcata tagatcgtac caggaagaag agaggcgaga     1020

aagatgaaac tgagtatgag tacagtggga gtgaggaaga agaggaggaa gtgcctgaac     1080

aggaaggaga gccaagttcc attgtgaacg tgcctggtga gtctactctt cgccgagatt     1140

tcctgagact gcagcaggag aacaaggaac gttccgaggc tcttcggaga caacagttac     1200

tacaggagca acagctccgg gagcaggaag aatataaaag gcaactgctg gcagagagac     1260

agaagcggat tgagcagcag aaagaacaga ggcgacggct agaagagcaa caaaggagag     1320

agcgggaagc tagaaggcag caggaacgtg aacagcgaag gagagaacaa gaagaaaaga     1380

ggcgtctaga ggagttggag agaaggcgca aagaagaaga ggagaggaga cgggcagaag     1440

aagaaaagag gagagttgaa agagaacagg agtatatcag gcgacagcta gaagaggagc     1500

agcggcactt ggaagtcctt cagcagcagc tgctccagga gcaggccatg ttactgcatg     1560

accataggag gccgcacccg cagcactcgc agcagccgcc accaccgcag caggaaagga     1620

gcaagccaag cttccatgct cccgagccca aagcccacta cgagcctgct gaccgagcgc     1680

gagaggttcc tgtgagaaca acatctcgct cccctgttct gtcccgtcga gattccccac     1740

tgcagggcag tgggcagcag aatagccagg caggacagag aaactccacc agcagtattg     1800

agcccaggct tctgtgggag agagtggaga agctggtgcc cagacctggc agtggcagct     1860

cctcagggtc cagcaactca ggatcccagc ccgggtctca ccctgggtct cagagtggct     1920

ccggggaacg cttcagagtg agatcatcat ccaagtctga aggctctcca tctcagcgcc     1980

tggaaaatgc agtgaaaaaa cctgaagata aaaaggaagt tttcagaccc ctcaagcctg     2040

ctgtaaggat tgatctgacc gcactggcca aagagcttcg agcagtggaa gatgtacggc     2100

cacctcacaa agtaacggac tactcctcat ccagtgagga gtcggggacg acggatgagg     2160

aggacgacga tgtggagcag gaaggggctg acgagtccac ctcaggacca gaggacacca     2220

gagcagcgtc atctctgaat ttgagcaatg gtgaaacgga atctgtgaaa accatgattg     2280

tccatgatga tgtagaaagt gagccggcca tgaccccatc caaggagggc actctaatcg     2340

tccgccagac tcagtccgct agtagcacac tccagaaaca caaatcttcc tcctccttta     2400

caccttttat agaccccaga ttactacaga tttctccatc tagcggaaca acagtgacat     2460

ctgtggtggg attttcctgt gatgggatga gaccagaagc cataaggcaa gatcctaccc     2520

ggaaaggctc agtggtcaat gtgaatccta ccaacactag gccacagagt gacaccccgg     2580

agattcgtaa atacaagaag aggtttaact ctgagattct gtgtgctgcc ttatggggag     2640

tgaatttgct agtgggtaca gagagtggcc tgatgctgct ggacagaagt ggccaaggga     2700

aggtctatcc tcttatcaac cgaagacgat ttcaacaaat ggacgtactt gagggcttga     2760

atgtcttggt gacaatatct ggcaaaaagg ataagttacg tgtctactat ttgtcctggt     2820

taagaaataa aatacttcac aatgatccag aagttgagaa gaagcaggga tggacaaccg     2880

taggggattt ggaaggatgt gtacattata aagttgtaaa atatgaaaga atcaaatttc     2940

tggtgattgc tttgaagagt tctgtggaag tctatgcgtg ggcaccaaag ccatatcaca     3000

aatttatggc ctttaagtca tttggagaat tggtacataa gccattactg gtggatctca     3060

ctgttgagga aggccagagg ttgaaagtga tctatggatc ctgtgctgga ttccatgctg     3120

ttgatgtgga ttcaggatca gtctatgaca tttatctacc aacacatgta agaaagaacc     3180

cacactctat gatccagtgt agcatcaaac cccatgcaat catcatcctc cccaatacag     3240

atggaatgga gcttctggtg tgctatgaag atgagggggt ttatgtaaac acatatggaa     3300

ggatcaccaa ggatgtagtt ctacagtggg gagagatgcc tacatcagta gcatatattc     3360

gatccaatca gacaatgggc tggggagaga aggccataga gatccgatct gtggaaactg     3420

gtcacttgga tggtgtgttc atgcacaaaa gggctcaaag actaaaattc ttgtgtgaac     3480

gcaatgacaa ggtgttcttt gcctctgttc ggtctggtgg cagcagtcag gtttatttca     3540

tgaccttagg caggacttct cttctgagct ggtagaagca gtgtgatcca gggattactg     3600

gcctccagag tcttcaagat cctgagaact tggaattcct tgtaactgga gctc           3654


<210> 1306
<211> 2487
<212> DNA
<213> Homo sapiens

<400> 1306
gaccagttgg cgacatggtg gcacccgtgc tggagacttc tcacgtgttt tgctgcccaa       60

accgggtgcg gggagtcctg aactggagct ctgggcccag aggacttctg gcctttggca      120

cgtcctgctc cgtggtgctc tatgaccccc tgaaaagggt tgttgttacc aacttgaatg      180

gtcacaccgc ccgagtcaat tgcatacagt ggatttgtaa acaggatggc tccccttcta      240

ctgaattagt ttctggagga tctgataatc aagtgattca ctgggaaata gaggataatc      300

agcttttaaa agcagtgcat cttcaaggcc atgaaggacc tgtttatgcg gtgcatgctg      360

tttaccagag gaggacatca gatcctgcat tatgtacact gatcgtttct gcagctgcag      420

attctgctgt tcgactctgg tctaaaaagg gtccagaagt tacctggaag actggccagg      480

tggaacgagg cagggcctgg aagccaccag cctctctcgc cctctgtagc aggagctgcg      540

actctatggt ttcatgttac gcttccattc tgtgcaaggc tctgtggaag gagaagctgc      600

acacattctg gcatcataac agaatttcat ttcttccatc tgcattcagg ccaataccaa      660

tattagcatg tggcaatgat gattgcagaa ttcacatatt tgctcaacaa aatgatcagt      720

ttcagaaagt gctttctctc tgtggacatg aggattggat tagaggagtg gaatgggcag      780

cctttggtag agatcttttc ctagcaagct gttcacaaga ttgcctgata agaatatgga      840

agctgtatat aaagtcaaca tctttagaaa ctcaggatga cgataacata agactgaaag      900

aaaatacttt taccatagaa aatgaaagtg ttaaaatagc atttgctgtt actctggaga      960

cagtgctagc cggtcatgaa aactgggtaa atgcagttca ctggcaacct gtgttttaca     1020

aagatggtgt cctacagcag ccagtgagat tattatctgc ttccatggat aaaaccatga     1080

ttctctgggc tccagatgaa gagtcaggag tttggctaga acagagagag tggactccag     1140

agattgtcat ttcaggacac tttgatggtg tccaagacct agtctgggat ccagaaggag     1200

aatttattat cactgttggt actgatcaga caactagact ttttgctcca tggaagagaa     1260

aagaccaatc acaggtgact tggcatgaaa ttgcaaggcc tcagatacat gggtatgacc     1320

tgaaatgttt ggcaatgatt aatcggtttc agtttgtatc tggagcagat gaaaaagttc     1380

ttcgggtttt ttctgcacct cggaattttg tggaaaattt ttgtgccatt acaggacaat     1440

cactgaatca tgtgctctgt aatcaagata gtgatcttcc agaaggagcc actgtccctg     1500

cattgggatt atcaaataaa gctgtctttc agggagatat agcttctcag ccttctgatg     1560

aagaggagct gttaactagt actggttttg agtatcagca ggtggccttt cagccctcca     1620

tacttactga gcctcccact gaggatcatc ttctgcagaa tactttgtgg cctgaagttc     1680

aaaaactata tgggcacggt tatgaaatat tttgtgttac ttgtaacagt tcaaagactc     1740

tgcttgcctc agcttgtaag gcagctaaga aagagcatgc agctatcatt ctttggaaca     1800

ctacatcttg gaaacaggtg cagaatttag ttttccacag tttgacagtc acgcagatgg     1860

ccttctcacc taatgagaag ttcttactag ctgtttccag agatcgaacc tggtcattgt     1920

ggaaaaagca ggatacaatc tcacctgagt tcgagccagt ttttagtctt tttgccttca     1980

ccaacaaaat tacttctgtg cacagtagaa ttatttggtc ttgtgattgg agtcctgaca     2040

gcaagtattt cttcactggg agtcgagaca aaaaggtggt tgtctggggt gagtgcgact     2100

ccactgatga ctgtattgag cacaacattg gcccctgctc ctcagtcctg gacgtgggtg     2160

gggctgtgac agctgtcagc gtctgcccag tgctccaccc ttctcaacga tacgtggttg     2220

cagtaggatt ggagtgtgga aagatttgct tatatacctg gaaaaagact gatcaagttc     2280

cagaaataaa tgactggacc cactgtgtag aaacaagtca aagccaaagt catacactgg     2340

ctatcagaaa attatgctgg aagaattgca gtggaaaaac tgaacagaag gaagcagaag     2400

gtgctgagtg gttacacttt gcaagctgtg gtgaagatca cactgtgaag atacacagag     2460

tcaataaatg tgcactgtaa tggactt                                         2487


<210> 1307
<211> 1425
<212> DNA
<213> Homo sapiens

<400> 1307
ccgagcgcgt tgctgcccgg aggctcctac gccacggccc gtcgggcccg gcgccggaag       60

tgagctgttc cgaggcgccg ccgggagctg ccacgtccga gacctggagc agccaccgcc      120

gcaatcatgg tgtcagtaat taacactgtg gatacctccc atgaggacat gattcacgac      180

gcccagatgg actactatgg cacccgcctg gcaacctgct catcagacag gtccgtcaaa      240

atctttgatg tgcgcaatgg agggcagatc cttatcgccg acctcagggg tcatgagggt      300

cctgtgtggc aagtggcctg ggctcacccc atgtacggca acatcctggc atcgtgctcc      360

tatgaccgga aagtcattat ctggagagag gaaaacggca cctgggagaa gagccacgag      420

catgcgggac acgactcctc agtgaactcg gtgtgctggg ccccccatga ctacggcctg      480

atcctggcct gtgggagctc ggatggggcc atctccctgc tgacttacac cggggaaggc      540

caatgggaag taaagaagat caacaacgct cacaccattg gctgcaatgc cgtcagctgg      600

gcccctgctg ttgtacctgg aagcctcata gaccacccat cggggcagaa acccaattac      660

atcaagaggt ttgcatcagg tggctgtgac aacctcatca agctgtggaa ggaggaggag      720

gacggccagt ggaaggagga gcagaagcta gaagcgcaca gtgactgggt tcgagatgtg      780

gcctgggccc cctccatcgg cctgcccacc agcaccatcg ccagctgctc ccaggatggt      840

cgtgtgttca tttggacctg tgatgatgcc tcaagcaata cgtggtcccc taaattgttg      900

cacaagttca acgatgtggt gtggcatgtg agctggtcca tcacagccaa catcctggct      960

gtctctggtg gagacaataa ggtgaccctg tggaaggagt cagttgatgg gcagtgggtg     1020

tgcatcagtg atgtcaacaa gggccagggc tccgtatcag catcagtgac agagggccag     1080

cagaacgagc agtgacaaga caggtggggc ctggctcccc acccgccagc tccaggactg     1140

ccccttcctg ggccaactaa ccagacaact gggaagagcc cccaactcca acaggattat     1200

tttcccagga ggagttacag atgcagccac agattgatca tctgccttaa cgtgatcgga     1260

gatgctttgt aatctactgt ccagctgaaa gcactcatgt tacgaggaag aaactacaag     1320

tgatgttcaa atctattttg ggtcattttt atgtaccttt gggttcaggc attatttggg     1380

gggttttgtt tccaaaggaa ctaaataaag tcatattgct tataa                     1425


<210> 1308
<211> 2628
<212> DNA
<213> Homo sapiens

<400> 1308
tcccgcctcc ttctgcgaac cgcaccaccc agatcccggg gtgcgcggag ggcgcgtctc       60

tgacggaagc cggggcggac ggtcggagtc cggaagaaaa acagtccgcg acagctaggc      120

gcgtgagacc ggccgcccgc agggctgctc tggccgggac ccgctggccg ggagacgcga      180

acctgccgga ccaccgcgcg gggacgacgg cggccatgag ctcgcggaag ctgagcgggc      240

cgaaaggcag gaggctcagc atacacgtcg tgacttggaa cgtggcttcg gcagcgcccc      300

ctctagatct cagtgacctg cttcagctga acaaccggaa cctcaatctt gacatatatg      360

ttattggttt gcaggaattg aactctggga tcataagcct cctttccgat gctgccttta      420

atgactcgtg gagcagtttc ctcatggatg tgctttcccc tctgagcttc atcaaggtct      480

cccatgtccg tatgcagggg atcctcttac tggtctttgc caagtatcag catttgccct      540

atatccagat tctgtctact aaatccaccc ccactggcct gtttgggtac tgggggaaca      600

aaggtggagt caacatctgc ctgaagcttt atggctacta tgtcagcatc atcaactgcc      660

acctgcctcc ccacatttcc aacaattacc agcggctgga gcactttgac cggatcctgg      720

agatgcagaa ttgtgagggg cgagacatcc caaacatcct ggaccacgac ctcattatct      780

ggtttggaga catgaacttt cggatcgagg actttgggtt gcactttgtt cgggaatcca      840

ttaaaaatcg gtgctacggt ggcctgtggg agaaggacca gctcagcatt gccaagaaac      900

atgacccgct gctccgggag ttccaggagg gccgcctact cttcccgccc acctacaagt      960

ttgataggaa ctccaacgac tatgacacca gtgagaaaaa acgcaagcct gcatggaccg     1020

atcgcatcct gtggaggctg aagcggcagc cctgtgctgg ccccgacact cccataccgc     1080

cggcgtcaca cttctccttg tctctgaggg gctacagcag ccacatgacg tacggcatca     1140

gcgaccacaa gcctgtctcc ggcacgttcg acttggagct gaagccattg gtgtctgctc     1200

cgctgatcgt cctgatgccc gaggacctgt ggaccgtgga aaatgacatg atggtcagct     1260

actcttcaac ctcggacttc cccagcagcc cgtgggactg gattggactg tacaaggtgg     1320

ggctgcggga cgttaatgac tacgtgtcct atgcctgggt cggggacagc aaggtctcct     1380

gcagcgacaa cctgaaccag gtttacatcg acatcagcaa tatccctacc actgaagatg     1440

agtttctcct ctgttactac agcaacagtc tgcgttctgt ggtggggata agcagaccct     1500

tccagatccc gcctggctcc ttgagggagg acccactggg tgaagcacag ccacagatct     1560

gagccaggat gggagtgaat cccaggcgga ggccagagct ggcagccagc tctgcctttc     1620

cactgccggg agtgctgggg gcccagcctg gccccctgaa gagacagcca agtgtcgtcc     1680

acatactcct cccagagtga gctctaacca ggctcatttg ctctctccac tactcatctc     1740

tggaattagc cgcttaaata caggtttttg ttgctgagat gtgagtgaaa ccagctagtg     1800

tgtcaacagt gaagacctgg ggacagttct gcgtctcatt tctggattcc taccccctct     1860

tctagtcttg cccaagtagt cctgccaggc acatgcccca tttggcacag gcctgcattc     1920

ttgtcgtgcc gtcctgggcc tcaggctgtc tgggagggga gatgctcaca tttgtacagg     1980

ctacatagac tggtgcaagc agtgctggat tccaggagtc ttggcatctc atagcttgtc     2040

cccgtgagga gtgagcagag ggtctgggat ttctgctttc agcaaaagca gtctgactca     2100

gtgggcagaa tggaggggcc cctctagcca ggctcttacg ccatggttat gagcaggttg     2160

atgagggtcc ttcggccagc acaaccttcc tccctactca cggcatggag tctgactgca     2220

tggaagttcc agatcctgac agagagaact gggaaggatc caggttcgct tccgttggta     2280

gcttgagtcc catgcctcca ccctgccatc tgaggaaggg gtgacaagtg gtcaaggagc     2340

tgtggccaca gacttttcca gggtggtcct tggcaggtga ggtgcgtctg tgccaccctt     2400

gtcaggagcc attgacgacg ggccccccct ggaccccccg ggacctcaga gtgggggcag     2460

gcagaaggga gaaccagctc aagacatttt ggaggatctg gccctggggt tcttcagaga     2520

acaccctcta ggggctttgg ggacatggcc tgtccccaca tccagcactt gcctccgcca     2580

tggtcactcg gcagcccttt tcccaggaga agacacctct gggagcct                  2628


<210> 1309
<211> 2146
<212> DNA
<213> Homo sapiens

<400> 1309
gtcccgttac cgcctcctgc tcctgccgcg cgcacccccg gggcttcggc tccggcacgg       60

gtcgcgccca gctttcctgc acctgaggcc gccggccagc cgccgccatg ggtgcctacc      120

tctcccagcc caacacggtg aagtgctccg gggacggggt cggcgccccg cgcctgccgc      180

tgccctacgg cttctccgcc atgcaaggct ggcgcgtctc catggaggat gctcacaact      240

gtattcctga gctggacagt gagacagcca tgttttctgt ctacgatgga catggagggg      300

aggaagttgc cttgtactgt gccaaatatc ttcctgatat catcaaagat cagaaggcct      360

acaaggaagg caagctacag aaggctttag aagatgcctt cttggctatt gacgccaaat      420

tgaccactga agaagtcatt aaagagctgg cacagattgc agggcgaccc actgaggatg      480

aagatgaaaa agaaaaagta gctgatgaag atgatgtgga caatgaggag gctgcactgc      540

tgcatgaaga ggctaccatg actattgaag agctgctgac acgctacggg cagaactgtc      600

acaagggccc tccccacagc aaatctggag gtgggacagg cgaggaacca gggtcccagg      660

gcctcaatgg ggaggcagga cctgaggact caactaggga aactccttca caagaaaatg      720

gccccacagc caaggcctac acaggctttt cctccaactc ggaacgtggg actgaggcag      780

gccaagttgg tgagcctggc attcccactg gtgaggctgg gccttcctgc tcttcagcct      840

ctgacaagct gcctcgagtt gctaagtcca agttctttga ggacagtgag gatgagtcag      900

atgaggcgga ggaagaagag gaagacagtg aggaatgcag cgaggaagag gatggctaca      960

gcagtgagga ggcagagaat gaggaagatg aggatgacac cgaggaggct gaagaggacg     1020

atgaagaaga agaagaagag atgatggtgc cagggatgga aggcaaagag gagcctggct     1080

ctgacagtgg tacaacagcg gtggtggccc tgatacgagg gaagcagttg attgtagcca     1140

acgcaggaga ctctcgctgt gtggtatctg aggctggcaa agctttagac atgtcctatg     1200

atcacaaacc agaggatgaa gtagaactag cacgcatcaa gaatgctggt ggcaaggtca     1260

ccatggatgg gcgagtcaac gggggcctca acctctccag agccattggg gaccacttct     1320

ataagagaaa caagaacctg ccacctgagg aacagatgat ttcagccctt cctgacatca     1380

aggtgctgac tctcactgac gaccatgaat tcatggtcat tgcctgtgat ggcatctgga     1440

atgtgatgag cagccaggaa gttgtagatt tcattcaatc aaagatcagc cagcgtgatg     1500

aaaatgggga gcttcggtta ttgtcatcca ttgtggaaga gctgctggat cagtgcctgg     1560

caccagacac ttctggggat ggtacagggt gtgacaacat gacctgcatc atcatttgct     1620

tcaagccccg aaacacagca gagctccagc cagagagtgg caagcgaaaa ctagaggagg     1680

tgctctctac tgagggggct gaagaaaatg gcaacagcga caagaagaag aaggccaagc     1740

gagactagca gtcatccaga cccctgccca cctagactgt tttctgagcc ctccggacct     1800

gagactgagt tttgtctttt tcctttagcc ttagcagtgg gtatgaggtg tgcaggggga     1860

gctgggtggc ttcactccgc ccattccaaa gagggctctc cctccacact gcagccggga     1920

gcctctgctg tccttcccag ccgcctctgc tcctcgggct catcaccggt tctgtgcctg     1980

tgctctgttg tgttggaggg aaggactggc ggttctggtt tttactctgt gaactttatt     2040

taaggacatt cttttttatt ggcggctcca tggccctcgg ccgcttgcac ccgctctctg     2100

ttgtacactt tcaatcaaca ctttttcaga ctaaaggcca aaacct                    2146


<210> 1310
<211> 3919
<212> DNA
<213> Homo sapiens

<400> 1310
atgctacagg ccttacagct tcgtactggc ttcttctgtt ttagggtgtt ggtggcactt       60

tctccctgtg ctttgcatga ctctggcaga cttaccacag gatcattcaa cgttgtcagg      120

gatgaagagg aagaaatcaa actggagata aatatgctaa agaaatactc tcatcacaga      180

aacattgcaa catattatgg tgctttcatc aaaaagagcc ctccaggaca tgatgaccaa      240

ctctggcttg ttatggagtt ctgtggggct gggtccatta cagaccttgt gaagaacacc      300

aaagggaaca cactcaaaga agactggatc gcttacatct ccagagaaat cctgagggga      360

ctggcacatc ttcacattca tcatgtgatt caccgggata tcaagggcca gaatgtgttg      420

ctgactgaga atgcagaggt gaaacttgtt gactttggtg tgagtgctca gctggacagg      480

actgtggggc ggagaaatac gttcataggc actccctact ggatggctcc tgaggtcatc      540

gcctgtgatg agaacccaga tgccacctat gattacagaa gtgatctttg gtcttgtggc      600

attacagcca ttgagatggc agaaggtgct ccccctctct gtgacatgca tccaatgaga      660

gcactgtttc tcattcccag aaaccctcct ccccggctga agtcaaaaaa atggtcgaag      720

aagtttttta gttttataga agggtgcctg gtgaagaatt acatgcagcg gccctctaca      780

gagcagcttt tgaaacatcc ttttataagg gatcagccaa atgaaaggca agttagaatc      840

cagcttaagg atcatataga tcgtaccagg aagaagagag gcgagaaaga tgaaactgag      900

tatgagtaca gtgggagtga ggaagaagag gaggaagtgc ctgaacagga aggagagcca      960

agttccattg tgaacgtgcc tggtgagtct actcttcgcc gagatttcct gagactgcag     1020

caggagaaca aggaacgttc cgaggctctt cggagacaac agttactaca ggagcaacag     1080

ctccgggagc aggaagaata taaaaggcaa ctgctggcag agagacagaa gcggattgag     1140

cagcagaaag aacagaggcg acggctagaa gagcaacaaa ggagagagcg ggaagctaga     1200

aggcagcagg aacgtgaaca gcgaaggaga gaacaagaag aaaagaggcg tctagaggag     1260

ttggagagaa ggcgcaaaga agaagaggag aggagacggg cagaagaaga aaagaggaga     1320

gttgaaagag aacaggagta tatcaggcga cagctagaag aggagcagcg gcacttggaa     1380

gtccttcagc agcagctgct ccaggagcag gccatgttac tgcatgacca taggaggccg     1440

cacccgcagc actcgcagca gccgccacca ccgcagcagg aaaggagcaa gccaagcttc     1500

catgctcccg agcccaaagc ccactacgag cctgctgacc gagcgcgaga ggtacagtgg     1560

tcccacctgg catctctcaa gaacaatgtt tcccctgtct cgcgatccca ttccttcagt     1620

gacccttctc ccaaatttgc acaccaccat cttcgttctc aggacccatg tccaccttcc     1680

cgcagtgagg tgctcagtca gagctctgac tctaagtcag aggcgcctga ccctacccaa     1740

aaggcttggt ctagatcaga cagtgacgag gtgcctccaa gggttcctgt gagaacaaca     1800

tctcgctccc ctgttctgtc ccgtcgagat tccccactgc agggcagtgg gcagcagaat     1860

agccaggcag gacagagaaa ctccaccagc agtattgagc ccaggcttct gtgggagaga     1920

gtggagaagc tggtgcccag acctggcagt ggcagctcct cagggtccag caactcagga     1980

tcccagcccg ggtctcaccc tgggtctcag agtggctccg gggaacgctt cagagtgaga     2040

tcatcatcca agtctgaagg ctctccatct cagcgcctgg aaaatgcagt gaaaaaacct     2100

gaagataaaa aggaagtttt cagacccctc aagcctgctg taaggattga tctgaccgca     2160

ctggccaaag agcttcgagc agtggaagat gtacggccac ctcacaaagt aacggactac     2220

tcctcatcca gtgaggagtc ggggacgacg gatgaggagg acgacgatgt ggagcaggaa     2280

ggggctgacg agtccacctc aggaccagag gacaccagag cagcgtcatc tctgaatttg     2340

agcaatggtg aaacggaatc tgtgaaaacc atgattgtcc atgatgatgt agaaagtgag     2400

ccggccatga ccccatccaa ggagggcact ctaatcgtcc gccagagtac agttgaccaa     2460

aagcgtgcca gccatcatga gagcaatggc tttgccggtc gcattcacct cttgccagat     2520

ctcttacagc aaagccattc ctcctccact tcctccacct cctcctcccc atcctccagc     2580

cagccgacac ccaccatgtc cccacagaca ccccaggaca agctcactgc taatgagact     2640

cagtccgcta gtagcacact ccagaaacac aaatcttcct cctcctttac accttttata     2700

gaccccagat tactacagat ttctccatct agcggaacaa cagtgacatc tgtggtggga     2760

ttttcctgtg atgggatgag accagaagcc ataaggcaag atcctacccg gaaaggctca     2820

gtggtcaatg tgaatcctac caacactagg ccacagagtg acaccccgga gattcgtaaa     2880

tacaagaaga ggtttaactc tgagattctg tgtgctgcct tatggggagt gaatttgcta     2940

gtgggtacag agagtggcct gatgctgctg gacagaagtg gccaagggaa ggtctatcct     3000

cttatcaacc gaagacgatt tcaacaaatg gacgtacttg agggcttgaa tgtcttggtg     3060

acaatatctg gcaaaaagga taagttacgt gtctactatt tgtcctggtt aagaaataaa     3120

atacttcaca atgatccaga agttgagaag aagcagggat ggacaaccgt aggggatttg     3180

gaaggatgtg tacattataa agttgtaaaa tatgaaagaa tcaaatttct ggtgattgct     3240

ttgaagagtt ctgtggaagt ctatgcgtgg gcaccaaagc catatcacaa atttatggcc     3300

tttaagtcat ttggagaatt ggtacataag ccattactgg tggatctcac tgttgaggaa     3360

ggccagaggt tgaaagtgat ctatggatcc tgtgctggat tccatgctgt tgatgtggat     3420

tcaggatcag tctatgacat ttatctacca acacatatcc agtgtagcat caaaccccat     3480

gcaatcatca tcctccccaa tacagatgga atggagcttc tggtgtgcta tgaagatgag     3540

ggggtttatg taaacacata tggaaggatc accaaggatg tagttctaca gtggggagag     3600

atgcctacat cagtagcata tattcgatcc aatcagacaa tgggctgggg agagaaggcc     3660

atagagatcc gatctgtgga aactggtcac ttggatggtg tgttcatgca caaaagggct     3720

caaagactaa aattcttgtg tgaacgcaat gacaaggtgt tctttgcctc tgttcggtct     3780

ggtggcagca gtcaggttta tttcatgacc ttaggcagga cttctcttct gagctggtag     3840

aagcagtgtg atccagggat tactggcctc cagagtcttc aagatcctga gaacttggaa     3900

ttccttgtaa ctggagctc                                                  3919


<210> 1311
<211> 2643
<212> DNA
<213> Homo sapiens

<400> 1311
aagttaagct gaagaccgaa gcaagagctg gttcaggtgg cagccacagc agcctcaggg       60

acctcagcaa ctatggcctc ctgcccagac tctgataata gctgggtgct tgctggctcc      120

gagagcctgc cagtggagac actgggcccg gcatccagga tggacccaga atctgagaga      180

gccctgcagg cccctcacag cccctccaag acagatggga aagaattagc tgggaccatg      240

gatggagaag ggacgctctt ccagactgaa agccctcagt ctggcagcat tctaacagag      300

gagactgagg tcaagggcac cctggaaggt gatgtttgtg gtgtggagcc tcctggccca      360

ggagacacag tagtccaggg agacctgcag gagaccaccg tggtgacagg cctgggacca      420

gacacacagg acctggaagg ccagagccct ccacagagcc tgccttcaac ccccaaagca      480

gcttggatca gggaggaggg ccgctgctcc agcagtgacg atgacaccga cgtggacatg      540

gagggtctgc ggagacggcg gggccgggag gccggcccac ctcagcccat ggtgcccctg      600

gctgtggaga accaggctgg gggtgagggt gcaggcgggg agctgggcat ctccctcaac      660

atgtgcctcc ttggggccct ggttctgctt ggcctggggg tcctcctctt ctcaggtggc      720

ctctcagagt ctgagactgg gcccatggag gaagtggagc ggcaggtcct cccagacccc      780

gaggtgctgg aagctgtggg ggacaggcag gatgggctaa gggaacagct gcaggcccca      840

gtgcctcctg acagtgtccc cagcctgcaa aacatgggtc ttctgctgga caagctggcc      900

aaggagaacc aggacatccg gctgctgcag gcccagctgc aggcccaaaa ggaagagctt      960

cagagcctga tgcaccagcc caaagggcta gaggaggaga atgcccagct ccggggggct     1020

ctgcagcagg gcgaagcctt ccagcgggct ctggagtcag agctgcagca gctgcgggcc     1080

cggctccagg ggctggaggc cgactgtgtc cggggcccag atggggtgtg cctcagtggg     1140

ggtagaggcc cacagggtga caaggccatc agggagcaag gccccaggga gcaggagcca     1200

gaactcagct tcctgaagca gaaggaacag ctggaggctg aggcacaggc attaaggcaa     1260

gagttagaga ggcagcgacg gctgctgggg tctgtacagc aggatctgga gaggagcttg     1320

caggatgcca gccgcgggga cccagctcat gctggcttgg ctgagctggg ccacagattg     1380

gcccagaaac tgcagggcct ggagaactgg ggccaggacc ctggggtctc tgccaatgcc     1440

tcaaaggcct ggcaccagaa gtcccacttc cagaattcta gggagtggag tggaaaggaa     1500

aagtggtggg atgggcagag agaccggaag gctgagcact ggaaacataa gaaggaagaa     1560

tctggccggg aaaggaagaa gaactgggga ggtcaggagg acagggagcc agcaggaagg     1620

tggaaggagg gcaggccaag ggtggaggag tcggggagca agaaggaggg caagcgacag     1680

ggcccgaagg aacccccaag gaaaagtggt agcttccact cctctggaga aaagcagaag     1740

caacctcggt ggagggaagg gactaaggag ctacccctct cacctgcttt ctttggtgag     1800

gatggcatct tccgtcatga ccgcctccgc ttccgggatt ttgtggatgc cctggaggac     1860

agcttggagg aggtggctgt gcaacagaca ggtgatgatg atgaagtaga tgactttgag     1920

gacttcatct tcagccactt ctttggagac aaagcactga agaagaggtc agggaagaag     1980

gacaagcact cacagagccc aagagctgcg gggcccaggg aggggcacag ccatagccac     2040

caccaccacc accggggctg acaccctgcc ccacagggaa tggccttggc ctggcccagc     2100

ccaagatccc agcgttatct aactcctgga gggtggactc tgtcctggct tgtttggtgt     2160

cctcagatat ctttcacaca gtagagcaaa atcaccagcc ctgcactgat gtcactttat     2220

gtagaaaaag gccttagctg gacctgcgtt gccgtctatg caaatgcatg caaatactcc     2280

aggccctggg atgtgggctt gtgttttgtc actgtgaagg gggagatggg agaggagcct     2340

gttttggggt ggggtctggg gaaggcaatc tgattctgaa gctaaagagc tttcatcctc     2400

ttgagtgtat gtccccatag tgggcccctt gacccacatg ctgaccggtg ccttgggatt     2460

tgactagagt tgctggctcg aggcccagca cgaggactta ccctggggtt ttgttaggtt     2520

tggaagcagc tgtccctagg gggtgaagtc cccccccttt ttttttttac ccctgcttct     2580

cccacggctt cacctcccta tgtgaactgt agactcagat cccaataaag tgctgttgca     2640

gct                                                                   2643


<210> 1312
<211> 2453
<212> DNA
<213> Homo sapiens

<400> 1312
ggaagtgcgc gtctcttgtt tgtgcggctg accagttggc gacatggtgg cacccgtgct       60

ggagacttct cacgtgtttt gctgcccaaa ccgggtgcgg ggagtcctga actggagctc      120

tgggcccaga ggacttctgg cctttggcac gtcctgctcc gtggtgctct atgaccccct      180

gaaaagggtt gttgttacca acttgaatgg tcacaccgcc cgagtcaatt gcatacagtg      240

gatttgtaaa caggatggct ccccttctac tgaattagtt tctggaggat ctgataatca      300

agtgattcac tgggaaatag aggataatca gcttttaaaa gcagtgcatc ttcaaggcca      360

tgaaggacct gtttatgcgg tgcatgctgt ttaccagagg aggacatcag atcctgcatt      420

atgtacactg atcgtttctg cagctgcaga ttctgctgtt cgactctggt ctaaaaaggg      480

tccagaagta ccaatattag catgtggcaa tgatgattgc agaattcaca tatttgctca      540

acaaaatgat cagtttcaga aagtgctttc tctctgtgga catgaggatt ggattagagg      600

agtggaatgg gcagcctttg gtagagatct tttcctagca agctgttcac aagattgcct      660

gataagaata tggaagctgt atataaagtc aacatcttta gaaactcagg atgacgataa      720

cataagactg aaagaaaata cttttaccat agaaaatgaa agtgttaaaa tagcatttgc      780

tgttactctg gagacagtgc tagccggtca tgaaaactgg gtaaatgcag ttcactggca      840

acctgtgttt tacaaagatg gtgtcctaca gcagccagtg agattattat ctgcttccat      900

ggataaaacc atgattctct gggctccaga tgaagagtca ggagtttggc tagaacaggt      960

tcgagtaggt gaagtaggtg ggaatacttt gggattttat gattgccagt tcaatgaaga     1020

tggctccatg atcattgctc atgctttcca cggagcgttg cacctttgga aacagaatac     1080

agttaaccca agagagtgga ctccagagat tgtcatttca ggacactttg atggtgtcca     1140

agacctagtc tgggatccag aaggagaatt tattatcact gttggtactg atcagacaac     1200

tagacttttt gctccatgga agagaaaaga ccaatcacag gtgacttggc atgaaattgc     1260

aaggcctcag atacatgggt atgacctgaa atgtttggca atgattaatc ggtttcagtt     1320

tgtatctgga gcagatgaaa aagttcttcg ggttttttct gcacctcgga attttgtgga     1380

aaatttttgt gccattacag gacaatcact gaatcatgtg ctctgtaatc aagatagtga     1440

tcttccagaa ggagccactg tccctgcatt gggattatca aataaagctg tctttcaggg     1500

agatatagct tctcagcctt ctgatgaaga ggagctgtta actagtactg gttttgagta     1560

tcagcaggtg gcctttcagc cctccatact tactgagcct cccactgagg atcatcttct     1620

gcagaatact ttgtggcctg aagttcaaaa actatatggg cacggttatg aaatattttg     1680

tgttacttgt aacagttcaa agactctgct tgcctcagct tgtaaggcag ctaagaaaga     1740

gcatgcagct atcattcttt ggaacactac atcttggaaa caggtgcaga atttagtttt     1800

ccacagtttg acagtcacgc agatggcctt ctcacctaat gagaagttct tactagctgt     1860

ttccagagat cgaacctggt cattgtggaa aaagcaggat acaatctcac ctgagttcga     1920

gccagttttt agtctttttg ccttcaccaa caaaattact tctgtgcaca gtagaattat     1980

ttggtcttgt gattggagtc ctgacagcaa gtatttcttc actgggagtc gagacaaaaa     2040

ggtggttgtc tggggtgagt gcgactccac tgatgactgt attgagcaca acattggccc     2100

ctgctcctca gtcctggacg tgggtggggc tgtgacagct gtcagcgtct gcccagtgct     2160

ccacccttct caacgatacg tggttgcagt aggattggag tgtggaaaga tttgcttata     2220

tacctggaaa aagactgatc aagttccaga aataaatgac tggacccact gtgtagaaac     2280

aagtcaaagc caaagtcata cactggctat cagaaaatta tgctggaaga attgcagtgg     2340

aaaaactgaa cagaaggaag cagaaggtgc tgagtggtta cactttgcaa gctgtggtga     2400

agatcacact gtgaagatac acagagtcaa taaatgtgca ctgtaatgga ctt            2453


<210> 1313
<211> 4781
<212> DNA
<213> Homo sapiens

<400> 1313
acgcgcatgg aacgcagcga aggactatgg caggggagaa cttcgctacg ccgttccacg       60

ggcacgtggg ccgcggcgcc ttcagcgacg tgtacgagcc cgcggaggac acgtttctgc      120

ttttgaacgc gctggaggca gcggctgccg aactggcagg agtggaaata tgcctggaag      180

tagggtcagg gtctggtgta gtatctgcat tcctagcctc tatgataggc cctcaggctt      240

tgtacatgtg cactgatatc aaccctgagg cagcagcttg taccctagag acagcacgct      300

gtaacaaagt tcacattcaa ccagttatta cagatttggt aggaagtcac ggaatagagg      360

cagcttgggc tggtggcaaa aatggtcggg aagtcatgga caggtttttt cccctggttc      420

cagatctcct ttcaccaaaa ggattattct atttagttac cattaaagaa aacaacccag      480

aagaaatttt gaaaataatg aagacaaaag gtctgcaagg aaccactgca ctttccagac      540

aagcaggcca agaaactctt tcagtcctca agttcaccaa gtcttagcat acagtgtgtg      600

cccagaacta ctggaaactg aatgcattta gcatattttg aaactgaagt cattcattag      660

gtaacaagga attttatcag aaatttgtca ttaaaaaaag gtagaaaggt ggaacattcc      720

ctttcagtca ggcctataga attatttgca caagtacaag taaatatgtg tattatattt      780

atagtttgca ttttaaatat aaaaattatg tatgaaatat ttatttcagc attatgtggt      840

aaggcaatgg aattgatctg gcaaatgtct tttttttcat accagtccat aaaggcagtt      900

tgctttcaga tggcagggcc agcaacacac cttcattgtc gtatctccgg tgtgtatcag      960

ctctccaact ctatgtcata attcagttca tggggatctt gattaccttt cccttccaca     1020

aaatattaca ctgattggtt atatcgatga cattatgctg atttgaccta gtgagcaaga     1080

agtaggaact acattagact tagtggaaag acatttgcat cagagggtag gaaataaata     1140

tgactacaat tcaagggcct tctaccttag tgaaattggt agggatccag tgacatgggg     1200

catgttagga tatttcttct acggtgaagg ataagtactt gcatcttgct gctcttaaaa     1260

ccaagaaaga ggcacaatac ttagtgggcc tctttgggtt ttggaggcaa cattttccaa     1320

tttcattatg ttataccagc ctgtttacca attgactcaa aaagctgcta gttttgagta     1380

gggcccagaa caagaaaaga gtctgcaaca ggtccaggct gctgtgcaag ctgctctgcc     1440

acttgggtca tatgatccag cagatccagt ggtgtttcag tggcagtggc agatagggat     1500

gctgtttgaa gcttctggca ggtccctata ggtgaatctt ggtttaggat tttagagcaa     1560

agccgtgcca ttaccaacaa ataactagtc tctttttgag aaacagctct tggcctgcta     1620

ctgggcctta gtagagactg atacttaatg agtcaccaag ttaccgtgca acctgagctt     1680

cccatcatga actggatgtt atctgagcca ccaacgcaca aagttggata tgcacagcaa     1740

cactctgtca tcagatggaa gtggtataca catgattggg cctgagaggc cctgaaggca     1800

caaggaagtt acatgaagaa gtaggccaaa tttccgtagt ccccacttct gctacctgcc     1860

ttctctcttc cagcctgcat cggtggcttc atggggactt ccctgtgatc agctgacaga     1920

gaaagagaag acttaggcct ggtttacaga gtgttctgta tgatatgcag gtaccaccct     1980

aaagtggata gctgcagcac tacatctcac ctctgggcta ccttgaagga cagtggtgaa     2040

gggaaatcct cctggtggac acaactttga gcagtccccc tgttgacttt gcttagaagg     2100

aaaaatagcc agatattcaa ttatatgcca attcataggc cgtggccagt ggtttggctg     2160

gatggtcagg gagttcaata taactggaaa attggtgaca aagaaatttg gagatgaagt     2220

atgtggatag acactgaatg ggcaaaaagg gtgaagatat ttgtgcccca tgtgaatgct     2280

caccaaaggg ttagcaaaaa aggattttaa taaagtggac aagataacct gttctgtgga     2340

tactagtagg cctctttctc cagccacacc tgtcatcacc caattgtttc atgagcaaag     2400

tagccatggt gacaagaata gaggttatgc atgggctcag caacgtggac ttctactcac     2460

caaggctgac ctggccaagg ctatctctga gtgcccagtc tgccagcaac agagaccaac     2520

actgagcccc tgatatgaca ccattcccca gggtcatcag tcagttgcct agtggcaggt     2580

tcattacatt gatccacctc tatcattgaa gggatagtgt tttatcctta ctgaaataga     2640

tcttactctg gatacagatt cactttccct tcgcgcaggg tgtctgctaa aactaccatc     2700

cgtggactta cagaatgtct catctatgac catggtattc cacacagcat tacaagaaac     2760

tcagttcaca gcaaaagtgt ggcagtgggc ccatgatcat ggaattttct taccatgttc     2820

cctactatct tgaatcaact ggctacatag agcagtggaa tggcattttg aagacagtaa     2880

taacaccagc tatatagcag tgccttgtag ggctgggaca aggttctcta gaagactgtc     2940

tatgctctga atcaacatcc agtatatggt gcatttctct tatgactggg attcacaggt     3000

ccaggaatca aggggtcaga ataggaagga caccattcgc tattagccct ggtgacccac     3060

tagcaaaatt tttgcttcct gttcccatga cttatgcact gctggcctag aggtcttaca     3120

tagggtggaa tattttccac tgagagacgc aatcatgatt taattgaact ggaagtttaa     3180

gactgctcct cagccatttg gggcttctta tgcctctaac tcaatagaca aatgagttac     3240

agtgctggct gggtgattgt tcctgactac caagtagaaa ctggactacc ccgaatggtg     3300

gtaaggtaaa gtatgttggg aatacacagg attccttagg gcatctctta gtgttatcat     3360

gccctgtgat taaggtcaat ggaaaactac agcctaattc agacaggacc actaatgatc     3420

cagacctttc aggaatgaag gtttgggtca ccaccaggta agtaccatga ccagatgaag     3480

tgcttgctga aggcaaaggg aatacagaat aaatggtgga ataaatacta gctttgatca     3540

tatgaccagt tacagaaaca cagactgtga ttgtcataag tatgtcctcc atattttgct     3600

ataactacat tttgtgtgtg tgtagctttg ttttcttctc atttccttat tctgtaacat     3660

aagatgcatt gattttatag catagtgttt aaatattgtt aattttttta actggctcca     3720

gtgttcaacc ttgattaatt ttacatcata gtatttaagt tatgggatat caaggagaga     3780

gtaaacatca catgaagact ttaccacctc ttctgggaaa cgggttaaag tgtttctggt     3840

ggaatgctgg attgttaatc gtgttagatg gaattatgac cttgttgttg tctttatgtg     3900

gcagttaagt atggtttaaa gagatgttta tgggtgccaa gttgacaagg gtaaacttgt     3960

gatggttaat tttatatgtc aacttgaata ggccacaggg tgccaaatat ctgtttaaac     4020

attattctga agtgtcttga gtgtgtttac agacaagatt tgcatttgaa ctgggggact     4080

cagtaaagga gatagccatc cccaaggtgg gtggacatca tccagtttgt tgagggcgta     4140

aataaaataa aaggcagagg aaggaagaat tcccccccct tttttttcct gcctcattgt     4200

ttgagctgtg acatctcatc ttctgtcctc agatggattt acatcactgg cttccctggt     4260

tctcaagcct ttggattcag actgaattat accacaggcc ttcctgggtc tccagcttat     4320

agatgacaga tcatgggacc tcttagcctc cataatcatg taagccactt tcttgtagta     4380

ctggtaaaag atatattaaa ccaatctata aaacagatag ctatgaaaga gaaaggtgac     4440

aggcacaagc ctaggcaaat agagaagggt tcctggacag cctctgactt gcctaggtca     4500

ttgtgcacac gtggcttgcc tgaatgaaca tgcccactgt gaaagattcc atttctcaac     4560

acatgtgcag taagggaaat aaatcaatgt ggctcaaact aaccgcccac acatggggtg     4620

gagccacaag gagtttgctc cttatgcagg ggagaagccg tgcctcttca gctcgtgtgt     4680

ggtggcctgg cattcaattt gtgaggtgta aaacctgcat gaaggacccc tctttttgtg     4740

gagagctttc cttttgccta ataaattctg ccctcctcgc c                         4781


<210> 1314
<211> 4750
<212> DNA
<213> Homo sapiens

<400> 1314
accactgacc gggacaaaac cctgccaggc atcagaaagc tccgcagttc ttgagttcca       60

catgcagagc agatgcgaca gctagaagtg agtagggccc agaccctggc ccaggaagat      120

ccactaaagg aggccatcct tccgccttct tctgcaggag tcaggatgga aaggcagatg      180

taaagtccct catggcgaaa tataacacgg ggggcaaccc gacagaggat gtctcagtca      240

atagccgacc cttcagagtc acagggccaa actcatcttc aggaatacaa gcaagaaaga      300

acttattcaa caaccaagga aatgccagcc ctcctgcagg acccagcaat gtacctaagt      360

ttgggtcccc aaagccacct gtggcagtca aaccttcttc tgaggaaaag cctgacaagg      420

aacccaagcc cccgtttcta aagcccactg gagcaggcca aagattcgga acaccagcca      480

gcttgaccac cagagacccc gaggcgaaag tgggatttct gaaacctgta ggccccaagc      540

ccatcaactt gcccaaagaa gattccaaac ctacatttcc ctggcctcct ggaaacaagc      600

catctcttca cagtgtaaac caagaccatg acttaaagcc actaggcccg aaatctgggc      660

ctactcctcc aacctcagaa aatgaacaga agcaagcgtt tcccaaattg actggggtta      720

aagggaaatt tatgtcagca tcacaagatc ttgaacccaa gcccctcttc cccaaacccg      780

cctttggcca gaagccgccc ctaagtaccg agaactccca tgaagacgaa agccccatga      840

agaatgtgtc ttcatcaaaa gggtccccag ctcccctggg agtcaggtcc aaaagcggcc      900

ctttaaaacc agcaagggaa gactcagaaa ataaagacca tgcaggggag atttcaagtt      960

tgccctttcc tggagtggtt ttgaaacctg ctgcgagcag gggaggccca ggtctctcca     1020

aaaatggtga agaaaaaaag gaagatagga agatagatgc tgctaagaac accttccaga     1080

gcaaaataaa tcaggaagag ttggcctcag ggactcctcc tgccaggttc cctaaggccc     1140

cttctaagct gacagtgggg gggccatggg gccaaagtca ggaaaaggaa aagggagaca     1200

agaattcagc caccccgaaa cagaagccat tgcctccctt gtttaccttg ggtccacctc     1260

caccaaaacc caacagacca ccaaatgttg acctgacgaa attccacaaa acctcttctg     1320

gaaacagtac tagcaaaggc cagacgtctt actcaacaac ttccctgcca ccacctccac     1380

catcccatcc ggccagccaa ccaccattgc cagcatctca cccatcacaa ccaccagtcc     1440

caagcctacc tcccagaaac attaaacctc cgtttgacct aaaaagccct gtcaatgaag     1500

acaatcaaga tggtgtcacg cactctgatg gtgctggaaa tctagatgag gaacaagaca     1560

gtgaaggaga aacatatgaa gacatagaag catccaaaga aagagagaag aaaagggaaa     1620

aggaagaaaa gaagaggtta gagctggaga aaaaggaaca gaaagagaaa gaaaagaaag     1680

aacaagaaat aaagaagaaa tttaaactaa caggccctat tcaagtcatc catcttgcaa     1740

aagcttgttg tgatgtcaaa ggaggaaaga atgaactgag cttcaagcaa ggagagcaaa     1800

ttgaaatcat ccgcatcaca gacaacccag aaggaaaatg gttgggcaga acagcaaggg     1860

gttcatatgg ctatattaaa acaactgctg tagagattga ctatgattct ttgaaactga     1920

aaaaagactc tcttggtgcc ccttcaagac ctattgaaga tgaccaagaa gtatatgatg     1980

atgttgcaga gcaggatgat attagcagcc acagtcagag tggaagtgga gggatattcc     2040

ctccaccacc agatgatgac atttatgatg ggattgaaga ggaagatgct gatgatggtt     2100

tccctgctcc tcctaaacaa ttggacatgg gagatgaagt ttacgatgat gtggatacct     2160

ctgatttccc tgtttcatca gcagagatga gtcaaggaac taatgttgga aaagctaaga     2220

cagaagaaaa ggaccttaag aagctaaaaa agcaggaaaa agaagaaaaa gacttcagga     2280

aaaaatttaa atatgatggt gaaattagag tcctatattc aactaaagtt acaacttcca     2340

taacttctaa aaagtgggga accagagatc tacaggtaaa acctggtgaa tctctagaag     2400

ttatacaaac cacagatgac acaaaagttc tctgcagaaa tgaagaaggg aaatatggtt     2460

atgtccttcg gagttaccta gcggacaatg atggagagat ctatgatgat attgctgatg     2520

gctgcatcta tgacaatgac tagcactcaa ctttggtcat tctgctgtgt tcattaggtg     2580

ccaatgtgaa gtctggattt taattggcat gttattgggt atcaagaaaa ttaatgcaca     2640

aaaccactta ttatcatttg ttatgaaatc ccaattatct ttacaaagtg tttaaagttt     2700

gaacatagaa aataatctct ctgcttaatt gttaactcag aagactacat tagtgagatg     2760

taagaattat taaatattcc atttccgctt tggctacaat tatgaagaag ttgaaggtac     2820

ttcttttaga ccaccagtaa ataatcctcc ttcaaaaaat aaaaataaaa gaaaaaggaa     2880

aatcattcag gaagaaatga cctgtctaaa aaaacctaag gaagaataat aatataagaa     2940

aggaaattta aaaacattcc acaagaagaa aaattattgt ttatacttct acttatggtt     3000

atatcttata ttctctattc aagtgacctg tcttttaaaa aggcagtgct gtcttacctc     3060

ttgctagtgg gttaaatgtt ttcaaaaatt atagcagtag tagaagtttt gtataaaatt     3120

tgtccttatt tgttaattgt atataaatgt taattatttg atacgaatgt tatgcattta     3180

gtatgcacat tgaagtctaa actgtagaag agtctaaaac aagttctctt tttgcagatt     3240

cacatactaa tggtttaatt ctgtgctctg tttaaagtac tattataact agagtagatc     3300

tgaatgagga taaccctaaa atcatgagga atggaagaat ggaccttgaa actacctagg     3360

cttttatgca tggcacctct ttataatgaa gacacttttt aaagtttttg tttttgtttc     3420

aattaccgct agattttttt ttctcttttt ttaaaatcca ttttactgga aagttggcca     3480

gcagagggag tagaaattat taaaattcta gtgtttggat tgggcccttc tctaacagta     3540

catactcatt cccaaagcaa tccaaaaaca aaatgtgaac catttgggtt tcaaatgtta     3600

agaacactaa atagcatgat ttaaaaaatg aaaaatgcta acacccaaga aaagaagata     3660

ttaagtgctt tttaacaact cctagagtac aaaatgagta catcataatg ctggctcttc     3720

tactaatgaa ccatcgagtg atattgaata aattatttat cttctcagtt tccttatctg     3780

taaattacaa tattagacta agtaagtttt tccaactctt cactaccaat taccttaggc     3840

ttttataatg ctccgcctac ttcagtccca tgtttcagaa gcttttgtct attttttaaa     3900

ctcattgatt aaataatgat taatgcattc tccacatttt aatattgcaa aggcccattg     3960

gagtttctga agtggctcca cagaattgaa ataatttcaa ataactgtaa aggaactgaa     4020

aatcttcaca gagatgaagt ggggtttcca ttaggtgctt tgaaatttga taacaaatca     4080

tcaacttcca ctggtcaata tatagatttt gggtgtctga ggccccaaga ttagatgcca     4140

ctaatctcca aagattccct ccaattatga aatattttaa tgtctacttt tagagagcac     4200

tagccagtat atgaccatgt gattaatttc ttttcacact agataaaatt acctggttca     4260

aaagtggttt ttgtttatta aatttggtaa taaatatata taatacacag acaggatagt     4320

ttttatgctg aagtttttgg ccagctttag tttgaggact ccttgataag cttgctaaac     4380

tttcagagtg ccctgagaca cttccagcca tccctcctcc tgccttcatt ggggcagact     4440

tgcattgcag tctgacagta attttttttc tgattgagaa ttatgtaaat tcagtacaat     4500

gtcagttttt aaaagtcaaa gttagatcaa gagaatattt cagagttttg gtttacacat     4560

caagaaacag acacacatac ctaggaaaga tttacacaat agataatcat cttaatgtga     4620

aagatatttg aagtattaat tttaatatat taaatatgat ttctgttata gtcttctgta     4680

tggaattttg tcacttaaga tgagctgcaa ataaataata ccttcaatgg ataaccttgc     4740

ctcctacttc                                                            4750


<210> 1315
<211> 3067
<212> DNA
<213> Homo sapiens

<400> 1315
gggaccaaga gcggaagtgg gtgtgacggg gacgggggcc cggtgggccc gcggaggaaa       60

gatactgggg agtgggagcc gcggggttca gagcgatgat tcccccacag gaggcatccg      120

ctcgacggcg ggagattgag gacaagctga agcaggagga ggagactctg tccttcatcc      180

gagacagcct ggagaagagc gaccagctca ctaagaacat ggtgtctatc ttatcatcct      240

ttgagagccg ccttatgaag ctggagaact ccatcatccc tgtgcacaag cagacggaga      300

atctgcagcg gctgcaggag aatgttgaga agacgctgtc ctgcctggac catgtcatca      360

gctactacca tgtgatcagt ggtgacgatg atctggaggc ccaggaggac gtgaccctgg      420

agcacctgcc cgagagcgtg ctccaggatg tcattcgcat ctcccgctgg ctggtggaat      480

atggccgcaa ccaagatttc atgaacgtct actaccagat acgctccagc cagctggacc      540

gctccatcaa aggactgaag gagcatttcc ataagagcag ttcttcctct ggggttccct      600

actcccctgc tatccccaac aagaggaaag acacacctac caagaagcca gtcaagcggc      660

cagggagaga tgacatgctg gacgtggaga ccgatgccta catccactgc gtcagtgcct      720

tcgtcaagct ggcgcagagc gagtaccagc tgctggccga catcatcccc gagcaccacc      780

agaagaagac cttcgactcc ctgatacagg atgccctgga tgggctgatg cttgaagggg      840

agaacatcgt gtctgctgcc cggaaggcca ttgtgcgaca cgacttctcc acggtgctca      900

ccgtcttccc catcctgcga cacctcaagc agaccaagcc tgagtttgac caggtgctcc      960

agggcacggc tgccagcaca aagaacaagc tgcctggcct catcacatcc atggagacca     1020

tcggtgccaa agcgctggag gacttcgcag acaacatcaa gaatgacccg gacaaggagt     1080

acaacatgcc gaaggacggc accgtacacg agctcaccag caatgccatc ctcttcctgc     1140

agcagctttt ggacttccag gagacggcag gcgccatgct ggcctcccaa gagaccagct     1200

cttcggccac cagctacagc tctgagttca gcaagcggct gctaagcacc tatatctgta     1260

aagtgctggg caacctgcag ttgaacttgc tgagcaagtc caaggtgtac gaggacccag     1320

ctctgagcgc catcttcctg cacaacaact acaattacat cctcaagtcc ctggagaagt     1380

ctgaactgat ccagctggtg gcagtgacac agaagactgc tgagcgctcc taccgggagc     1440

acattgagca gcagatccag acctaccagc gcagctggtt aaaggtgact gattacatcg     1500

cagagaagaa tctacctgtg ttccagccgg gagtcaagct ccgggacaag gagcggcaga     1560

ttatcaagga gcgttttaag ggcttcaatg atggcctcga agaactgtgc aaaatccaga     1620

aggcctgggc tattccagac acagagcaga gggacaggat tcgccaggcc cagaagacca     1680

ttgtcaagga gacctacggg gcctttctac agaagtttgg cagcgtgccc ttcaccaaga     1740

acccggagaa gtacatcaag tacggggtgg agcaggtggg cgacatgatc gatcgccttt     1800

tcgacacctc tgcctgagcc tgctgctagc cctgcctggt tccaccagac tggcgtgtca     1860

ttggacagat aaaccagtgt tagcttgcct ctgggctggg tgagcttgaa gtcctctggg     1920

acagagacct gtctccacgc ctccgggagc tgtgtccctg agccccctag tcctggctcc     1980

tgctttttcc ccacagcccg tgttcccagc cgaaccagca ctctcccgga agcctggggt     2040

ccctccacac cttggctttt atgaccctga tggcttctga aacaggaaaa gagagaagga     2100

agacagaggc ctgtgcccac tgctgctcca tgtgtaccaa gagcagcagg gcagaagggc     2160

cctccctcca gcctaggtca gaggtgggga cagagaactc ccctacagcc cagagatgtg     2220

gcagggctca gagaagcagc cagagctcct ggaggaaagg cagtcgggac tgaccccctc     2280

tcttaaaaca cattcccgcc cgcccacagg cctgaggtct gggacctttc cctcccagga     2340

gtcccctagg tggctggggg aggcaggctc actggccatt ttccctagag tccagcacac     2400

tgcaggaggc gttcggagga ggagttccgc cccaccctct acagccttcc tcaggcccct     2460

gtctctggcc cccagcctca gtgcctcttg gcccagggcc aggcagtcgt ggttgcagaa     2520

ggagcaatta ggctgcctgc ctgtgggctg ggagacaggg acaatgggga aaagttaagg     2580

agcaaaatgg gggttggaag caaaaaatag ggccccacct atttaggacg agattgaaga     2640

ctgacccttg aggcacactt gcactggaga tgggtttatt tcacgctctg tgcttgtgtg     2700

ctagcggagg gagagctcag ggtggcttaa tccagaggcc ctgtcatggc ccgcccccag     2760

ccatgggaaa gcaaacttca tcctaaggtg tgcagcccag gccctgcccc tttacagtct     2820

aggccgcctg ccatggggtg cagcctctcc aggggctgcg tcagacttgc acgctgccca     2880

catccagatt cctgcaaaga cgaattgggt gcacagcacc ccaaccacat acacgaggaa     2940

gaagatgcgg tcagcagtct caggccagct tctctgtgac ccctttactc ctctggaggg     3000

ctctgtgggg agagatacag ggaaaggagc tgttcttcaa ggtcccctca acatgagcgg     3060

aagagcg                                                               3067


<210> 1316
<211> 2856
<212> DNA
<213> Homo sapiens

<400> 1316
cgcaccaccc ccttcccgcc gcgctctctc ccgcccccgc gcttccggcc ccgcccgccc       60

ccgcgcggag gactgtggga gcggcttcct tggattccgc gcttggcaac ggctcggcgt      120

cgcgctttgg ccaaccgctg cgtcgtccct gggcccgaat aactgtcgcc cgcttccctc      180

agcgtgaggt acaaatgatg caaaatgtgc acctggctcc agagacagat gaagatgatc      240

tttattccgg ctataatgac tacaatccaa tctatgatat cgaggaattg gagaatgatg      300

cagcttttca gcaagctgtg aggactagtc atggcagaag acctccaata actgctaaaa      360

tatcaagcac ggcagttact agacctatag ctactggata tgggtccaag acatctctgg      420

catcatcaat aggaagacca atgacagggg ctattcagga tggagttact agacccatga      480

cagcagtgag agcagctggt tttaccaaag cagctttgag aggctctgca tttgaccccc      540

ttagtcagtc aaggggccct gcttcccctt tggaagccaa gaaaaaagat agcccagagg      600

aaaaaataaa gcaattagag aaggaagtaa atgagttggt agaagaaagc tgtattgcca      660

atagttgtgg agacttaaaa ttggccttag aaaaggcaaa agatgcagga agaaaagaga      720

gagtcctggt gagacagcga gaacaagtta caactccaga aaatatcaat ttggatttaa      780

cttactcagt tcttttcaat ttggccagtc agtattcagt taatgaaatg tatgccgaag      840

cacttaacac ttatcaagtt atagtcaaaa ataagatgtt tagcaatgca ggaatattga      900

aaatgaatat gggaaatatc tatttaaagc aaagaaatta ttccaaagcc attaaattct      960

accgaatggc attagaccaa gttccaagtg tcaataagca aatgaggatt aaaataatgc     1020

agaatattgg agttacattt attcaggctg gtcagtattc agatgctatt aattcatatg     1080

agcacataat gagcatggca ccaaatctga aggcaggcta caacctaact atctgttatt     1140

ttgctattgg agaccgagaa aaaatgaaga aggcattcca aaaattgatt actgttccat     1200

tagaaattga tgaagataaa tatatttcac caagtgatga tcctcatact aacttagtaa     1260

ctgaagctat aaaaaatgat cacctcaggc aaatggaacg tgaaaggaaa gccatggcag     1320

aaaaatatat tatgacatct gcaaaactca ttgctcctgt aattgaaaca tcttttgctg     1380

caggttatga ttggtgcgtg gaagtggtga aagcttctca atatgtagag ctagccaatg     1440

atctggaaat aaacaaagca gttacatact tgagacaaaa agactataac caagctgtag     1500

agatcttaaa agtgttggaa aaaaaggaca gtagagtgaa aagtgcagct gcaaccaatc     1560

tctcagccct gtattatatg ggaaaggatt ttgcacaagc cagcagctat gcagatatag     1620

ctgtgaactc tgatagatat aatccagcag ctcttactaa taaagggaat acagtttttg     1680

caaatggtga ttatgagaag gccgctgaat tctataaaga ggctctaaga aatgattctt     1740

cttgtactga agcactttat aatattggcc ttacctatga gaaactaaat cggctagatg     1800

aggctttgga ctgtttcctg aaacttcacg caatcctacg aaacagtgcc gaagttcttt     1860

accagatagc aaatatatat gaattaatgg aaaatcccag tcaagctatt gaatggctaa     1920

tgcaggtggt cagtgttatt ccaaccgatc ctcaagtttt atctaagcta ggagaattat     1980

atgatcgtga aggagataaa tctcaagcat ttcaatatta ctatgagtca tataggtatt     2040

ttccttgtaa tattgaagtc attgagtggc ttggagccta ttacattgac acccaatttt     2100

gggaaaaagc tattcagtac tttgaaagag cttctcttat acagcctaca caagtgaaat     2160

ggcagctgat ggtagctagt tgtttcagaa gaagtggtaa ctaccaaaaa gcattagata     2220

cttacaaaga tactcacaga aaatttccag aaaatgtcga atgtctgcgt ttcttagttc     2280

gtctctgcac agatcttgga ttaaaagatg ctcaagaata tgccagaaaa ctgaagaggt     2340

tggaaaaaat gaaagaaata agggaacagc gcataaagtc aggcagagat ggcagtgggg     2400

gctcccgtgg caaaagagaa ggaagtgcta gcggtgatag tggccagaac tatagtgcca     2460

gtagtaaagg tgaacgacta agtgccagac tcagagcttt acctgggaca aatgaacctt     2520

atgaaagtag cagtaacaaa gaaatagatg cctcctatgt ggacccactt ggccctcaaa     2580

tagaacgacc aaaaactgca gccaagaaaa ggatcgatga ggatgatttt gctgatgaag     2640

aattaggaga tgatttgctt ccagaataat attcacttta atatttatta aaggaaagaa     2700

attgccttat gagatcatcc tcatgttaaa ccttggatta aatatctaac ctgtaattat     2760

tttttttcac tgtcaaaact taagtaagtg tattctattc tgtatgtatg catttaagtt     2820

gtttttttct tttaaggaat aaaaacaggt aaaact                               2856


<210> 1317
<211> 3516
<212> DNA
<213> Homo sapiens

<400> 1317
attggtgagt ggggcagggc aggagggaac tgaagagtga gaaagcatta tttcagcaaa       60

aggtctttcc tcccttgctc tctcctccaa ccactggctc agcctctccg cccgctgcct      120

gtgaatgatg caatggaagg tgtgctgggg tcgccctgtg tcccgtgcat aggagcatct      180

cagcctccag gtcctctcct ttggggctca cggcaccccc atgctacgaa ccgcaggcag      240

ggacggcctc tgtcgcctgt ccacctactt ggaagaactc gaggctgtgg aactgaagaa      300

gttcaagtta tacctgggga ccgcgacaga gctgggagaa ggcaagatcc cctggggaag      360

catggagaag gccggtcccc tggaaatggc ccagctgctc atcacccact tcgggccaga      420

ggaggcctgg aggttggctc tcagcacctt tgagcggata aacaggaagg acctgtggga      480

gagaggacag agagaggacc tggtgaggga taccccacct ggtggcccgt cctcacttgg      540

gaaccagtca acatgccttc tggaagtctc tcttgtcact ccaagaaaag atccccagga      600

aacctacagg gactatgtcc gcaggaaatt ccggctcatg gaagaccgca atgcgcgcct      660

aggggaatgt gtcaacctca gccaccggta cacccggctc ctgctggtga aggagcactc      720

aaaccccatg caggtccagc agcagcttct ggacacaggc cggggacacg cgaggaccgt      780

gggacaccag gctagcccca tcaagataga gaccctcttt gagccagacg aggagcgccc      840

cgagccaccg cgcaccgtgg tcatgcaagg cgcggcaggg ataggcaagt ccatgctggc      900

acacaaggtg atgctggact gggcggacgg gaagctcttc caaggcagat ttgattatct      960

cttctacatc aactgcaggg agatgaacca gagtgccacg gaatgcagca tgcaagacct     1020

catcttcagc tgctggcctg agcccagcgc gcctctccag gagctcatcc gagttcccga     1080

gcgcctcctt ttcatcatcg acggcttcga tgagctcaag ccttctttcc acgatcctca     1140

gggaccctgg tgcctctgct gggaggagaa acggcccacg gagctgcttc ttaacagctt     1200

aattcggaag aagctgctcc ctgagctatc tttgctcatc accacacggc ccacggcttt     1260

ggagaagctc caccgtctgc tggagcaccc caggcatgtg gagatcctgg gcttctctga     1320

ggcagaaagg aaggaatact tctacaagta tttccacaat gcagagcagg cgggccaagt     1380

cttcaattac gtgagggaca acgagcctct cttcaccatg tgcttcgtcc ccctggtgtg     1440

ctgggtggtg tgtacctgcc tccagcagca gctggagggt ggggggctgt tgagacagac     1500

gtccaggacc accactgcag tgtacatgct ctacctgctg agtctgatgc aacccaagcc     1560

gggggccccg cgcctccagc ccccacccaa ccagagaggg ttgtgctcct tggcggcaga     1620

tgggctctgg aatcagaaaa tcctatttga ggagcaggac ctccggaagc acggcctaga     1680

cggggaagac gtctctgcct tcctcaacat gaacatcttc cagaaggaca tcaactgtga     1740

gaggtactac agcttcatcc acttgagttt ccaggaattc tttgcagcta tgtactatat     1800

cctggacgag ggggagggcg gggcaggccc agaccaggac gtgaccaggc tgttgaccga     1860

gtacgcgttt tctgaaagga gcttcctggc actcaccagc cgcttcctgt ttggactcct     1920

gaacgaggag accaggagcc acctggagaa gagtctctgc tggaaggtct cgccgcacat     1980

caagatggac ctgttgcagt ggatccaaag caaagctcag agcgacggct ccaccctgca     2040

gcagggctcc ttggagttct tcagctgctt gtacgagatc caggaggagg agtttatcca     2100

gcaggccctg agccacttcc aggtgatcgt ggtcagcaac attgcctcca agatggagca     2160

catggtctcc tcgttctgtc tgaagcgctg caggagcgcc caggtgctgc acttgtatgg     2220

cgccacctac agcgcggacg gggaagaccg cgcgaggtgc tccgcaggag cgcacacgct     2280

gttggtgcag ctaccagaga ggaccgttct gctggacgcc tacagtgaac atctggcagc     2340

ggccctgtgc accaatccaa acctgataga gctgtctctg taccgaaatg ccctgggcag     2400

ccggggggtg aagctgctct gtcaaggact cagacacccc aactgcaaac ttcagaacct     2460

gaggctgaag aggtgccgca tctccagctc agcctgcgag gacctctctg cagctctcat     2520

agccaataag aatttgacaa ggatggatct cagtggcaac ggcgttggat tcccaggcat     2580

gatgctgctt tgcgagggcc tgcggcatcc ccagtgcagg ctgcagatga ttcagttgag     2640

gaagtgtcag ctggagtccg gggcttgtca ggagatggct tctgtgctcg gcaccaaccc     2700

acatctggtt gagttggacc tgacaggaaa tgcactggag gatttgggcc tgaggttact     2760

atgccaggga ctgaggcacc cagtctgcag actacggact ttgtggttgc agctggatag     2820

ctgtggcctc acagccaagg cttgtgagaa tctttacttc accctgggga tcaaccagac     2880

cttgaccgac ctttacctga ccaacaacgc cctaggggac acaggtgtcc gactgctttg     2940

caagcggctg agccatcctg gctgcaaact ccgagtcctc tggttatttg ggatggacct     3000

gaataaaatg acccacagta ggttggcagc gcttcgagta acaaaacctt atttggacat     3060

tggctgctga atggtcctat ctgctggctc tcccctgaga tctggacaga ggaagatggg     3120

agggtgctca tcaccccccc agcataatga tcagcctcct tcctagagac agactcatgc     3180

agattgagat caaaagtccc tctgcttggg atcaaattaa tgtttgacag agctggccag     3240

gcgtggtggc tcatgtatgt aatcctagca cttcgagagg ccgaggcagg tggatcacga     3300

ggtcaggagt ttgagattag cctggccaag atggtgaaac cctgtctcta ctaaaaataa     3360

aaaaaaatta gccaggcatg gtggcgggca cctgtagtcc cagctactca ggaggctgag     3420

gcaggagaat cgcttgaacc cgggaggtgg aggttgcagt gagccgagat cgcgccactg     3480

cactccagcc tgggcgacag agtgggactc catctc                               3516


<210> 1318
<211> 7033
<212> DNA
<213> Homo sapiens

<400> 1318
ctgggcatcc acttgacagc cggcggcgct cgcggccctc agcatgttcc gcgaggcgag       60

ggttttcctc ccgcctgtgg gctgaggcgg cggcggcccc cgaaacgaga tgcacctgac      120

gggcgcggct tagaggacgc ggctggcggg aagtcccggc agccagcggg agggctttcg      180

ttgccgggcc gccgccgcct cccgtcgccg ccgcgggccc gagcgggagc ggcgggtggg      240

cgccccgaca tggcggcccg gagcgccccg agctgccacc tgcggctcga gtgggtgtac      300

ggctaccggg gccaccagtg ccgcaacaac ctctactaca ctgcggccaa ggagatcgta      360

tacttcgtgg cgggggtcgg cgtggtgtac agcccgcggg agcacaggca gaagttctac      420

cggggccaca gcgacgacat catcagcctt gcattgcatc ctgaacgagt gttggtagca      480

acaggacaag ttgggaaaga gccttatatt tgtatttggg attcatacac tgtgcagacc      540

atatcagttt taaaggatgt tcatacacat ggtatagctt gcttggcgtt tgacttagat      600

ggacagcgct tggtttcagt tggacttgat tcaaagaatg cagtttgtgt ttgggactgg      660

aaaaggggaa aaatgttgtc tatggctcct ggtcatacag atagaatatt tgatatttct      720

tgggatttgt accagccaaa taaacttgtc agctgtggtg taaaacatat caagttctgg      780

agtttatgtg gaaatgctct gaccccaaaa cgaggtgtct ttggtaagac gggtgacctt      840

cagacaatac tgtgcctagc ctgtgcaagg gatgaattaa catattctgg tgcactcaat      900

ggggatatat atgtttggaa aggaatcaat cttatacgaa caatacaagg agcccatgct      960

gcaggaattt ttagcatgaa tgcttgtgaa gaaggctttg ctactggtgg cagagatggt     1020

tgtattcgtc tttgggattt aacttttaaa ccaattactg tgattgatct cagggaaaca     1080

gaccagggat acaaaggttt gtctgtaagg agtgtgtgtt ggcgaggtga ccacattcta     1140

gttggaacac aggacagtga aatttttgaa attgtggtgc aagaaagaaa taaacctttt     1200

ctaattatgc aagggcattg tgaaggtgaa ctttgggcac ttgctgtcca tcctactaaa     1260

cctttggctg tgactggaag tgatgatcgt tcggtcagga tatggagcct agtagatcat     1320

gcattaatag caaggtgtaa tatggaagaa ccaattcgtt gtgcagctgt caatgcagat     1380

ggaatccatc ttgcccttgg aatgaaggat ggctcattca ctgtacttag agtaagagat     1440

atgacggaag ttgtacatat taaagatagg aaggaggcaa ttcatgagtt aaaatattca     1500

ccagatggaa cttaccttgc tgttggatgc aatgacagct cggttgatat ttatggagtt     1560

gctcagcgtt ataaaaaagt tggcgagtgt ttgggatccc ttagtttcat cactcatctg     1620

gactggtctt cagacagtag atatttgcag acaaatgatg gaaatgggaa aagacttttt     1680

tatagaatgc caggaggaaa ggaagtgaca agtacagaag aaataaaagg tgttcattgg     1740

gcttcatgga catgtgtttc aggccttgaa gtaaatggaa tttggcccaa gtattcagat     1800

atcaacgata taaattcagt agatggaaat tatattggcc aagttttagt tacagctgat     1860

gactatggaa ttataaaatt attccgatat ccatgtttaa gaaaaggggc caagtttaga     1920

aaatatattg gccattcagc tcacgtaact aatgtcagat ggtcacatga ttatcagtgg     1980

gttatttcta ttggtggagc agatcactct gtctttcagt ggaaatttat tcctgaaaga     2040

aaactgaaag atgctgttca catagcaccc caagaaagtc tggctgactc tcatagtgat     2100

gaatcagatt cagatctgtc tgatgttcca gaactggatt ctgaaattga acaagagaca     2160

cagctcacct accgtcgaca ggtttacaaa gaagatctac ctcagcttaa agaacagtgc     2220

aaagagaaac aaaaaagtgc tacttctaaa agaagagagc gggctccagg aaatagtatt     2280

cgattacact ttgttcacgg ttacagaggt tatgactgtc gaagtaatct gttttatact     2340

caaattggtg aaattgtgta ccatgtggca gcagtgggtg tcatttataa tcgacagcaa     2400

aacacacagc gtttttatct gggtcatgat gatgatattc tctgcctaac tattcatcct     2460

ttgaaagact acgtggcaac aggccaggtt ggtagagatc cctcaattca tatatgggat     2520

acagagacca ttaaaccatt gtccatatta aagggccacc accagtatgg tgttagtgcc     2580

gttgatttct cagcggatgg gaaacgtttg gcatcagttg gcatagatga tagccatact     2640

gttgtgctct gggactggaa gaaaggagag aaactttcaa tagcaagagg aagtaaagat     2700

aagatttttg ttgtaaagat gaacccctat gtgcctgata aactaattac agctggaatt     2760

aaacacatga aattttggcg taaagcagga gatgtgtgta tctggagaga catctttctt     2820

gtaaaaacag tgaaagcgca tgatgggcca gtgttcagta tgcatgcatt ggaaaaaggg     2880

tttgtaactg gaggaaaaga tggtatagta gctctttggg atgactcttt tgaaagatgt     2940

ctcaagacct atgctataaa aagagctgca ttggccccag gatctaaagg tcttctcttg     3000

gaagataatc catctatacg tgccatatca ttaggacatg gtcatatttt agttggcaca     3060

aagaatggtg aaatactaga agtggataaa agtggcccaa taacacttct ggttcaggga     3120

cacatggaag gagaggtgtg gggtttagct acacaccctt atctgcccat ctgtgctact     3180

gtaagcgatg ataaaacctt aagaatatgg gatctctcac ctagtcattg tatgttggct     3240

gtccggaagc tgaaaaaggg tgggaggtgt tgctgttttt ctcctgatgg taaagcttta     3300

gccgtaggtc tcaacgatgg aagcttctta atggcaaatg cggatactct agaggatctt     3360

gtgtcttttc atcacagaaa agatatgatt tcagatattc gattttcacc tggttctggg     3420

aaatatcttg ctgtagcatc ccatgacagc tttatagata tatacaatgt aatgagtagt     3480

aaacgagtag gaatatgcaa aggagctacc agttacataa cccatattga ttgggatatt     3540

agaggaaagc ttttacaggt caacactggt gctaaggaac aattattctt tgaagctccc     3600

agagggaaaa aacaaaccat ccccagcgtg gaggtagaaa aaattgcttg ggcatcatgg     3660

acaagtgtac ttggtttatg ctgtgaagga atttggccag taattggaga agttacagat     3720

gtaactgctt cttgcctcac cagtgacaaa atggttctag ctaccgggga cgatttggga     3780

tttgtgaagt tatttagata tcctactaaa gggaaatttg gaaagtttaa gaggtatgtg     3840

gcccatagta cacatgtcac aaatgttcgc tggacttatg atgacagcat gttggttacc     3900

ctaggcggta cagatatgtc tttaatggtg tggacaaatg agatggaagg ctatcgagaa     3960

aaaaggcctt gtgatagtga agaatccgac attgattctg aagaagatgg gggctatgac     4020

agtgatgtta caagggagaa tgaaatcagt tacaccatca gagccttatc aacaaatatt     4080

cgcccaatgt taggaatcaa gcctcattta caacaaaaag aaccctcaat tgatgaaagg     4140

cctccagtga gcagggcccc accacagcca gagaaactcc agacaaacaa tgtaggcaag     4200

aaaaagagac ctatagagga ccttgtgttg gagctcattt ttggttatcg aggcagagac     4260

tgtaggaata atgttcacta tttaaatgat ggtgatgata taatttatca cactgcatct     4320

gttggaattc tgcacaatgt tgctacaggt tctcagagtt tttatcagga acataatgat     4380

gatattctgt gcctcacagt aaaccagcac cccaaattta tcaacatagt ggcaactggc     4440

caagtagttt tgagctgttc tttgttaact acagctcctt ctattcacat ctgggatgca     4500

atgaacaagc agactttatc tatcctaaga tgctaccatt caaagggagt atgttcagtc     4560

agcttcagtg ctactggcaa actattgctg tctgtgggac tagacccaga acatactatt     4620

accatttgga gatggcagga aggtgccaaa attgccagca gagctggtca caatcaacgt     4680

atttttgtgg cagaattccg accagattca gatacccagt ttgtctcagt gggagtaaaa     4740

catgtgaagt tctggaccct ggcaggaaga gctcttctta gcaaaaaagg gctactgagc     4800

acactggaag atgcccggat gcagaccatg ctcgctattg catttggtgc aaataacttg     4860

acgtttacag gtaccatcag tggtgatgtc tgtgtgtgga aagatcacat attgtgtaga     4920

atcgtggcga gagctcacaa cgggcctgtg tttgccatgt acaccaccct gcgagatgga     4980

cttatcgtga ctgggggaaa ggaaaggccg tcaaaagaag gaggagcggt taaactgtgg     5040

gatcaggaac tgaggcggtg ccgtgccttc aggcttgaga caggacaagc cacagattgt     5100

gttcgttctg tgtgcagagg caaaggcaag atccttgttg ggacaaggaa tgctgaaata     5160

atcgaagttg gagagaaaaa tgcagcttgt aatattttag ttaacggtca tgtggatggg     5220

ccaatctggg gactagcaac acatccttcc agggattttt tcctttctgc tgcagaagat     5280

gggacagtga gactttggga tattgctgat aaaaagatgt taaacaaagt gaatttggga     5340

catgctgctc gtactgtgtg ttacagccct gaaggggaca tggtggctat tggaatgaaa     5400

aatggagaat ttatcatttt actagtgagt tctctaaaaa tatggggaaa gaagagagac     5460

aggagatgtg caatccatga tatcagattt agtccggatt cccggtatct ggcagtaggt     5520

tctagtgaga actcagtgga tttttatgac ctaacgctgg gccccactct taacagaatc     5580

agctactgca aagacattcc aagctttgtc attcaaatgg acttctctgc agatagcagt     5640

tatctccagg tctctagtgg ctgctataaa cggcatgtct atgaagtgcc ttcaggaaaa     5700

catcttatgg atcatgccgc tattgacaga attacttggg ctacatggac tagtattcta     5760

ggagatgagg ttttgggaat ctggtccaga catgctgaga aagctgatgt caactgtgcc     5820

tgtgtatctc attcaggaat cagtcttgtt acaggagatg actttggcat ggttaagtta     5880

tttgacttcc catgtccaga aaaatttgca aaacacaaaa ggttcttggg tcattcgccc     5940

catgtgacaa atattcgatt taccagtggt gatcgacatg ttgttagtgc tggaggtgat     6000

gactgcagct tatttgtctg gaaatgtgta catacacctc actgagagat gctgagatga     6060

ctacagaaat taactttgag accagaatta cagagaagaa aaaccaaaac ccaaccctgc     6120

atggtcaagt ggtgctaacc caagactgta acagggagaa atgcccagaa tcatcaaaat     6180

agtgaaagac tgatctgttc aaaatatttg ctatatgcac tgggtataat ccgtaatcca     6240

tacactgcca gataatgcca tttcaaggaa ggatcgaata cttgatggta aaggccaagt     6300

ccccctgtat tgggaagtgt gtgatttcgg cagacctgct gggaaaattt agggtagagc     6360

actctttaca gaagaactca aaaacccaat ttggataatt ttcattatct ttttagcaaa     6420

atggtttctt aatgtttata ttttattttc aaggttcatt gtttaatgaa atattttatt     6480

cttgcatttc cataaggaaa gggaaagtca tgatcatcct aaaggatcac agtttttaaa     6540

aggcaaacat tttccctaag gaaacagaca caagctttcc tagagaatat gatgtttttt     6600

aggcattaat aaggtccttt tttataaagg acacttttct cctagtagtt ttgaattcag     6660

gaacagatcc aaagttagca gtatatggct gctacatttc cattttcatt ttcgagccat     6720

cagtttatgt tcagatgcca tctctgtaat cgcacattta aaacataact gtagcctcac     6780

taatggaaaa gtagtatgat gaacaatcat tcccaatggt gtacaatgta agggttttag     6840

ggagcaacag tatttaactg gaagaaagaa ttgcatattt aatgtagtct aatatataca     6900

catttgttta acatgtaaac aaaagtgtta aattcacata tacaacatta tacaatttaa     6960

tcactcttgg aataaaattt ttatagcctt ttttctattg ggaaaatttg tttagatgtg     7020

tgccactcca tag                                                        7033


<210> 1319
<211> 604
<212> DNA
<213> Homo sapiens

<400> 1319
aattgcctct caccccccgg aggggttatt ttgggggtgg ttggaggcgg tggcggcggc       60

ggcgaggagg ggaatttcct tgtgcctcca ttcccgggag gggggagcgg cgttggaggc      120

caccgtttcc agggttatat cctgtgttgt gacctcatgg tttaagtggg aataaagatg      180

agtataagca gtgatgaggt caacttcttg gtatatagat acttgcaaga gtcaggattt      240

tctcattcag catttacctt tggtatagaa agccatatca gtcagtccaa tataaatggt      300

gccctcgtcc cacccgctgc attgatttct atcatccaga aaggtctaca gtatgtagaa      360

gcagaagtta gtattaatga ggatggtacc ttgtttgatg gtcgaccaat agagtctctg      420

tccctgatag atgccgtaat gcctgatgta gtacaaacaa gacaacaagc ttatagagat      480

aagcttgcac agcaacaggc agcagctgct gcagctgccg cagctgcagc cagccaacaa      540

ggatctgcaa aaaatggaga aaacacagca aatggggagg agaatggagc acatactata      600

gcaa                                                                   604


<210> 1320
<211> 2143
<212> DNA
<213> Homo sapiens

<400> 1320
gttgccatgg cgactatgta cacagccagg cagccccgcg tggggagtgc aggtggtttc       60

ggttgcggca gtcgcgtccc gggagcgtcg ctgcctggtg aacgctagaa tgggtactag      120

gaaaaaagtt catgcatttg tccgtgtcaa acccaccgat gactttgctc atgaaatgat      180

cagatacgga gatgacaaaa gaagcattga tattcactta aaaaaagaca ttcggagagg      240

agttgtcaat aaccaacaga cagactggtc gtttaagttg gatggagttc ttcacgatgc      300

ctcccaggac ttggtttatg agacagttgc aaaggatgtg gtttctcagg ccctcgatgg      360

ctataatggt ttttaggatg atcgaagaac gccccacaca tgccatcact gtgcgtgttt      420

cctacttgga aatctataat gagagcctgt ttgatctcct gtccactctg ccctatgttg      480

gaccctcagt cacaccaatg accatcgtgg aaaaccctca aggagtcttc attaagggct      540

tgtcagttca cctcacaagt caggaggagg atgcattcag cctccttttt gagggtgaga      600

ccaacaggat tatagcctcc cacactatga acaaaaactc ttccagatca cactgcattt      660

tcaccatcta cttagaggcc cattcccgga ccttatcaga ggaaaagtac atcacttcca      720

aaattaactt ggtggatctg gcaggctcag agaggctggg gaagtctggg tctgagggcc      780

aagtcctgaa ggaagccacc tacatcaaca aatcgctctc attcctggag caggccatca      840

ttgcccttgg ggaccagaag cgggaccaca tcccctttcg gcagtgcaag ctcacccacg      900

ctctgaagga ctcgttaggg ggaaactgca atatggtcct cgtgacaaac atctatggag      960

aagctgccca gttagaagaa acgctatctt cactgagatt tgccagcagg atgaagctag     1020

tcaccactga gcctgccatc aatgaaaagt atgatgctga gagaatggtc aagaacctgg     1080

agaaggaact agcactactc aagcaggagc tggctatcca tgacagcctg accaaccgca     1140

cctttgtgac ctatgacccc atggatgaaa tccagattgc tgagatcaac tcccaggtgc     1200

ggaggtacct ggaggggaca ctggacgaga tcgacataat cagccttaga cagatcaagg     1260

aggtgttcaa ccagttccgg gtggttctga gccaacagga acaggaagtg gagtccactt     1320

tgcgcaggaa gtacaccctc attgacagga atgactttgc agccatttct gctatccaga     1380

aggcggggct tgtggatgtt gatggccacc tagtgggtga gcctgaagga caaaactttg     1440

gactcggagt cgcccctttc tctaccaaac ctgggaagaa agccaagtcc aagaagacat     1500

tcaaagagcc actcaggccc gacaccccac cctccaaacc agtggccttt gaggagttta     1560

agaatgagca aggtagtgag atcaaccgaa ttttcaaaga aaacaaatcc atcttgaatg     1620

aacggaggaa aagggccagc gagaccacac agcacatcaa tgccatcaag cgggagattg     1680

atgtgaccaa ggaggccctg aatttccaga agtcactacg ggagaagcaa ggcaagtacg     1740

aaaacaaggg gctgatgatc atcgatgagg aagaattcct gctgatcctc aagctcaaag     1800

acctcaagaa gcagtaccgc agcgagtacc aggacctgcg tgacctcagg gctgagatcc     1860

agtattgcca gcacctagtg gatcagtgtc gccaccgcct gctcatgggt gcgacagttg     1920

ggaagaattt gacatctggt acaatgagtc ctttgtcatc cctgaggaca tgcagatggc     1980

actgaagcca ggcggcagca tccggccagg catggtccct gtgaacagga ttgtgtctct     2040

gggagaagat gaccaggaca aattcagcca gctgcagcag agggtgcttc ctgagggccc     2100

tgattccatc tccttctaca atgccaaagt caagatagag cag                       2143


<210> 1321
<211> 1686
<212> DNA
<213> Homo sapiens

<400> 1321
attgctctaa aaggcctctg tgccctgact gatcctccct ccctgtcaac tcctaatctt       60

tttattgtct ccatagtttt gccttttcca gaatgttgta atcatacagt atgtagtctt      120

tttgaattgg cttctttcac ttagcaatgt gcatttaagt ttcctaagct gttgatcatg      180

agactgagtc cctttttata cttcaacaga catgagaacg gcctcaagga agactaacca      240

tctgcaatac tagaagccat ggctgaggga tcagtgatgt tcagtgatgt gtccatagac      300

ttctctcagg aggagtggga ctgcctggac cctgttcaga gggacttata cagagatgtg      360

atgttggaga actacggcaa tctggtttca atgggacttt acactcctaa gcctcaagtg      420

atctccttat tggaacaagg gaaagagccc tggatggttg gcagagagct tacaagaggc      480

ctgtgttcag atctggaatc gatgtgtgaa accaagttat tatctctaaa gaaggaagtt      540

tatgaaatag aattatgcca gagggagata atgggactta caaagcatgg ccttgagtac      600

tccagttttg gagatgtttt ggaatataga agccaccttg caaaacaact gggatatcca      660

aatgggcatt ttagtcaaga aatattcact cctgaataca tgcccacatt tattcaacag      720

acattcctta ctctccatca aataattaat aatgaagaca gaccctatga atgtaagaaa      780

tgtggaaagg cctttagtca gaactcacaa tttattcaac atcagagaat tcatattggt      840

gaaaaatctt atgaatgtaa agagtgtggg aaattcttta gttgtggttc acatgttact      900

cggcatctga aaattcatac tggcgaaaaa ccctttgaat gtaaggaatg tggaaaggcc      960

ttcagttgta gctcatacct ttctcaacat cagagaatcc ataccggtaa gaaaccctat     1020

gaatgtaagg aatgtgggaa ggcctttagt tattgctcaa atcttattga ccatcagcga     1080

attcacactg gtgaaaaacc ttatgaatgt aaagtatgtg ggaaagcctt tactaagagc     1140

tcacaacttt ttcagcatgc acgaattcat acaggtgaga aaccctatga atgtaaggaa     1200

tgtggcaaag cctttaccca gagctcaaag cttgttcaac atcagagaat tcatactggt     1260

gagaaaccct atgagtgcaa ggaatgtggc aaagccttta gtagtggctc agcacttact     1320

aatcatcaga gaattcacac tggtgagaaa ccctatgatt gtaaggaatg tggaaaggct     1380

tttactcaga gctcacagct tcgtcaacat cagagaattc acgctggtga gaaacccttt     1440

gaatgtcttg aatgtgggaa ggcctttact cagaactcac aacttttcca gcatcagaga     1500

attcatacag atgaaaaacc atatgaatgt aatgaatgtg gaaaggcctt taataaatgc     1560

tcaaacctta ctcgacatct gagaattcac actggtgaaa agccctataa ctgtaaggaa     1620

tgtgggaagg cttttagtag tggctcggat ctcattcgtc atcagggaat tcatactaat     1680

aaataa                                                                1686


<210> 1322
<211> 2498
<212> DNA
<213> Homo sapiens

<400> 1322
attcacggca cccctgatag cgaggtcggc gtcacggtgt aggcgcgcag ttggggaaac       60

cgaggcccaa cgtgggcggc agctaccaga gatggcacac ggaggactca aattcgtcca      120

ttcagtcatt cgttcattca ttccttcggg aaaccttgca gatctcccaa tctgggcaac      180

tctgagctgg gcgccagtag tctgggggtg ctgacgggag gaggggccag agttttcaaa      240

gacgattaac cgaggctcac gtcgcggagc caacctagaa gttctctggg gacagaacct      300

tggcggacaa ctgaattaat tgttctagtc tccaggccca gtacatggat gcttgttgga      360

tgaattaatg aaccttgacc cacaccaaga ttctgagaat ttggtttctg tcaagatgtg      420

cctctccagc caggcctctc ctgccaggac ggtggccaca gggccatctc cctctcctgg      480

cgcccccaac tgcctggcca aggtgactgc tacacacgtg gggtcgcaga atccctcgag      540

tcacaacgtc ttcaacgtct tgtcagtccc gtgatcgcac taaacgtatt taaagccccc      600

tactccttta agagggtcac ctctgtgtac aggcggcctc ctcgtactaa gtgtggtggc      660

gttcaaggct ccgagacaca ggcgcctccc gcgccactcc ccgggcacag gaactcctac      720

tcatccctca gtcatcagct cgaaggtttc ttctccaaga agcctgcccg gcactcgaga      780

agtagagccg cgagccttct cccgggggcc cagccttccc cagtaccggc agggatcacc      840

ccgggagcac gcgcccggcc ccgctgaggc caggggctcc tcggaggcgc gggaaagccg      900

gggaaccagc gcagttacgg cacacacgag gcggggcctg cacagatgcc gggcgcccga      960

tcctcagtga caaaatagag actccgtgga agggacactg aggtggggga ggctgcggtg     1020

atcccatacc gcactccagg tgccaggctc cgccccgccc ctgacggcgc ttccggatcc     1080

ggcgggtgcc ggaagtgggc gggcggcggc ggctgcgcgc ggaggcggtg gaggaggtgc     1140

tgggagcagc cgggcagccg cttcccgccc ccgagcagga gccggtgcga gcggagcaga     1200

gccgaggtcg ggccgcgagc ggagccggct gagcgggcgc cgagctcccg ccatggcccg     1260

gaacacgctg tcctcgcgct tccgccgggt ggacatcgac gaatttgacg agaacaaatt     1320

tgtggacgag caggaggagg cggcggcggc ggcggcggag ccaggcccgg acccgagcga     1380

ggtggacggg ctcctgcggc aaggggacat gcttcgggca ttccatgcag ccttgcggaa     1440

ctctcccgtc aacaccaaga atcaagctgt gaaggagcga gcccagggcg tggtgctgaa     1500

agtgctcaca aacttcaaga gcagtgagat tgagcaggct gtgcagtcac tggacagaaa     1560

cggcgttgac ttgttaatga agtacattta taaaggcttt gagaagccca cagaaaatag     1620

cagcgcagtg ttactccagt ggcacgaaaa ggccttagca gtaggaggac taggctccat     1680

tataagagtt cttacagcaa gaaagactgt ttaaaaaaaa taaaaagact catgttacct     1740

tgagaagaat tctggatgcc caggctggtg aagaagggat tgacaatgga ccatcttcct     1800

aggaactccc aagtaaacta tttcaggaca tgtatctgct gaaatgtatt ttattttcaa     1860

ggtggagggg aaaatcgtct gtttcctaaa tcctgtttag gatctgatag tctatgcctt     1920

tgtctccgag tactgcagaa ctgacatttt gacggtctac cagcgtggcg gctggtgttg     1980

gtcagatgca cctgtgtgca ctgggggagg gatggtttgg gcaggtgcag atccaagggc     2040

tgtggtaaac gggagagctt gtgtttttga agtggaaaaa aacccaagag tttgtacaga     2100

catcctgtct tcccagagaa ggtggacact cttgggctca ttgtaaagtg cctgctgcat     2160

caataaagct cttggcttat tagtctatac attgcggtgt gtttcgtgta tgtaaaaaaa     2220

aatggtaatg aatgggatgg taatgaatga gagttcagtt gttgttccgg aaacccgatg     2280

tggaaggagt agacctgtgt ccctgttgag ccacccctgg gagcgagcat ggcaatccac     2340

aggccctctg ccacaggacg ccagcctcgg cctcagagct gccggctgct gcagagaggt     2400

gtttgctgaa taaactattt attgtttctt attcctttga tttgtatgta attaattttg     2460

gagcttattt aattaattta ataaagtgcc aaacattt                             2498


<210> 1323
<211> 7164
<212> DNA
<213> Homo sapiens

<400> 1323
gacgcggccg gcggggcgga cgggagcggg ccgcgcgtgg cggcggcgat gggcgagggc       60

gggctgcccc cggccttcca gctgctgctg cgcgcgtgtg accagggcga cacggagacg      120

gcgcggcggc tgctggagcc gggggcggcg gagccagccg agcgcggcgc ggagccggag      180

gcgggcgcgg agccggcggg ggccgaggtg gccgggcccg gggccgcagc ggcgggggca      240

gtcggggctc cggtgcccgt ggattgctcg gacgaggcgg gcaacaccgc actgcagttc      300

gccgcggccg ggggccacga accgctggtg cgcttcctgc tgcgccgcgg tgcctcggtc      360

aacagccgca accactacgg ctggagcgcg ctcatgcagg cggccagatt tgggcatgtg      420

agtgtggcac acctcctgtt ggatcacggg gctgatgtca atgcccagaa ccggctgggg      480

gccagtgtgc tcactgtggc ttctcggggc ggccacctgg gtgtggtgaa gctgctcctg      540

gaagccggtg cctttgtgga ccatcaccac ccttcaggcg agcaactggg gttgggcggc      600

agcagggatg agcccttgga catcacagcc ctgatggctg ccatccagca cgggcacgag      660

gccgtggtgc gtctactgat ggagtggggc gcggacccca accacgcagc ccggaccgtg      720

ggctggagcc cgctgatgct ggccgcactc actgggcggc ttggagtggc ccagcagctg      780

gtggagaagg gcgccaaccc tgaccacctc agcgtgctgg agaagaccgc cttcgaggtt      840

gcactggact gcaagcacag ggaccttgta gactacctgg acccgctgac caccgtcagg      900

cccaaaacag atgaggagaa aaggcgacct gatattttcc atgcattgaa aatgggaaac      960

ttccagctgg tcaaagagat tgccgatgaa gaccccagcc acgtgaactt ggtcaatggg     1020

gacggggcga cgccactgat gctagcagct gttacggggc agctggctct ggtgcagctg     1080

ctggtggaga ggcacgcgga tgttgacaag caggacagcg tgcatggctg gacggccctc     1140

atgcaggcaa cctaccatgg gaataaggaa attgtgaaat atctgctaaa ccaaggggcc     1200

gatgtcactc ttcgtgcaaa aaatggatac acggcctttg acctggtgat gctgctgaat     1260

gatcccgaca cggaacttgt tcgactgctg gcatctgtct gcatgcaggt gaataaagac     1320

aaaggccggc cgagccacca gcctcccctg ccccactcga aggtccgaca gccctggagc     1380

atcccagtgc tgcccgatga caagggtgga ctgaagtcct ggtggaaccg aatgtccaat     1440

cggttccgaa agctcaaact gatgcagacg ctgccccgtg ggctgtccag caaccagcct     1500

ttgcctttct ctgacgagcc tgagccagct ctggactcca caatgagggc tgccccccag     1560

gacaagacaa gccgctctgc actccctgat gcggcccctg tgaccaaaga caatggtcct     1620

gggagcacaa gaggagaaaa ggaagacacg ttattgacaa ccatgcttcg aaacggagct     1680

cccctcacca gactcccgag tgacaagctg aaagcagtca tccccccatt cctaccccct     1740

tccagttttg agctgtggag ctctgatcgg tcccggacgc gtcacaacgg gaaggcagac     1800

cccatgaaga ctgcgctgcc ccagagagcc agcaggggcc accccgtggg cggcgggggc     1860

acagacacta cacccgtcag gcctgttaaa tttccaagcc tccccagaag cccagcctct     1920

tctgccaatt ctggaaactt caaccactcg cctcattcat cgggcggctc cagtggggta     1980

ggtgtgagcc ggcacggtgg ggagctgctt aaccgctcag gtggcagcat agacaatgtc     2040

ttgtcccaaa tcgctgccca gaggaaaaaa gcagccggat tattggagca gaaacccagc     2100

catcggtcaa gccctgtggg gccagcaccg gggtccagcc cgtctgagct tccagcctcc     2160

cctgcaggtg gcagcgctcc tgttggcaag aaattggaga ccagcaaaag gcctccatct     2220

ggaacttcca ctacctccaa gagcacctct ccaaccctca cgccctcccc ctcacccaaa     2280

gggcacactg cagagtcctc agtgtcttcc tcgtcatccc atcggcagtc caagagcagt     2340

gggggctcca gcagtggcac catcacagat gaggatgaac tgactggaat ccttaagaaa     2400

ttatcacttg agaaatatca gcccattttt gaggaacaag aggtggacat ggaagcgttc     2460

ctcacactga ctgacggtga cttgaaggag ctgggaatta agacagatgg gtccaggcag     2520

cagattctgg cagcgatttc tgaactgaac gcaggcaagg gacgcgagag acaaatttta     2580

caggaaacca ttcacaactt tcactcttcc tttgagagca gtgccagcaa caccagggcc     2640

cctggcaaca gcccctgtgc gtgatcctcc ttcccgcagc caccagcgtg agctctctga     2700

atcccgggac cccttcacgt ggccacagcc ccagccctgc ccccgtcaca ctgctgtgcc     2760

ttagtcatgt tgttcccttt gctcgggatg cccacttcac gtcgacggca ttcattggta     2820

gtacttcttg ctgcaacaaa cttcaacaca cagagacaga ttcccatgta acagtccagt     2880

gggggtgctt ctgcttggca ggttggttca cacagtgatg cagggactca gctcctttca     2940

tcctgtgctc tgccctcccc gggagcctca gagtttgctt ctggctggcg gcaagggaaa     3000

gggacgatgg agaaggcacg gctgcttctt acctgccttg ctcttaactg acacacatca     3060

ctcctgctca cgtcctcttg gccactggta gtcatgtggc cccacctgga tgcagaggag     3120

gccaggatgt gcagtctcca catagtggct tcccagcaac aacttttgac ttagatgggg     3180

ggtatgtatt atggtgagag gttagccttc ctggcacatc ttcccttaaa acttctaact     3240

tgcccctcct agtccaagtc acctctcaga tgaagtcttt tttgaccccc tttcagccac     3300

tgggtccctt agtgctgtgt atgtgactgc tgtagcattc cactgcacct gctgcataca     3360

gcttacattg gagatgtgta tgtcaaacgc atttttcttt attgcaaaga gagtctatta     3420

tagaaggaaa gaagtggagg cctgctgtgt ggatcccttc ttcttcctag ctttcagttt     3480

ccttatctgc aaagtggaag gtcagaccag atgatgctct ggtactccac agtgctcacc     3540

tgtatcactg cagggctttc tgcactgaaa gtggaagcag aaggctaatg ggtcacattg     3600

tgtaaaggtc tctggtgctc aaagtttcta ggcaaagaag tgaaaatttg gaattttgtc     3660

tacatcctat taatgctgtg ttcctcaaaa gggaattggc ttgtgtagtt tcctaccata     3720

tcatatttta ttaaattaga ggggccctga cttttaaaac ccactggctt tctgaagtgt     3780

tttccagtga atgactcatt cagccagtgc ttgttgcatt tatgttagct accaggtgcc     3840

aagtgtgcag acacaataca gagccttcag gctctcgaca ggcaagagaa cacctgtaaa     3900

tagatggtcc cgacattgag aggcagcatg gtagagtggg cagaccttgt gctctggact     3960

caggttcaaa gttcagatga agctcaatgg cctcttagtt ggagcttaga accagtatgc     4020

ccaaagtgct gggtctgcag gaagtaccca gtcgatggta ggctgcacag aattctgatc     4080

tctaccttga gccatgctga gccacaagtt ggtctccttg ggaggtgcca tctctcatct     4140

gtccctcccc cagccatgaa agcccattcc cctatgctgg ctttcagagg ctgtcgttaa     4200

cttactgccc agagcctcgt agttttcttc ccctgccctg atggttgggt gtttttcctt     4260

taaattctct cagccttaca ctcacagaag ccaactttcc acaggactga agacaaagtg     4320

tttcatttag ctgttactga tagacacctt tacaaaggtt actaatgtcc cagccttttt     4380

aaggagacac actcattcat cccctactat gtgctggcag ctttaccttt gtcatttcat     4440

cctcatggcc accctggagg tggcattgtg taacctcatc ttgcacattc gggaaacgga     4500

tgcttaggag agggaagcag cttgccagtt aaacagccca gaaggagcag atctggggtc     4560

agaaccggac ctggtgggct tgcaagcctg tgccttttcc actaactcct atagactcct     4620

ggagctagaa gcacttgtga ttcttgtttt aatttactga tggcttcagg ggttaacagt     4680

aggcctagaa ttgtttgcct ctgaaattca tggcccctga cgttatgtgc tttgaggttt     4740

tgtgcctgct ttttgctgtg gtcctgtttt tttcataaca atatactggt atagcttcca     4800

ctcaggtaag tttgattgaa caatgataca cagctgcacc ggggggtcac cttttcacaa     4860

atgtagacct ccatgaactc attggatgac cctggacaga gcggggctat tcccattttg     4920

cagacaggac agcagaggct ccagacaatg cctttccttt ctttttcact ggactcaagt     4980

gtccaaggct tttcatccta ggaagtttgt gtgctggttc acaagaggtc cctggcaccc     5040

tttctgggga tgtttggatg cggctggtag gcagggaaga gaaagggcac cccagcgggg     5100

gcatgtgtgg aggcagcacg gaacatgtag gttatagatc gtcagggagg aggggtcagt     5160

tgggtgcttg tttttctgat ttttggtcct tgatcacccc cttcccttcc cacacgtgtc     5220

cccagcctgc ctgtggctgt tccccccaca agaagcacct cccttgcttg gcaaccttca     5280

ccagcatttc ccaaaagtat gctcctggga accctagttc cacaggataa taggtttttc     5340

ataaagaaac gtagggtgtg tatgtgaaag tggggtgagg ttccctggtt gagtaggttt     5400

ggcagacact aaagcgagct acacgatcat ctttgctaca ggcctctcac aaccttcagc     5460

atgccagcat gggtcaggcc tcttcacagg gccaagaaac tcatagcatc tcccacatta     5520

ctctcatcac ttctccaagg tgcttttgca agactggaat tccttggaca ccattggaga     5580

agccccgctt tttctggaac agcggcaacc aagaggcctt gcagccctgg aagtgggtca     5640

gggcccttgg tggtcacctt tttctcccca gcagctctgc agaggtggcc tgcttggcag     5700

tgggacatca ggggaccggt cctgctttga gatggcaggg tccctgttct gagagctctc     5760

cagcctgagg gcattgagct gaggctccac cctgagctct cctgcagggt ggagggcatt     5820

gtttcccagc acccaggcag tgtcttgctg gtgtgtcgtg agtgctggat gtccaagtcc     5880

ctgctggcca cggagggctc ctgcctctct tcttcagcgc cacaaaatta catggaggcc     5940

agctggtttt gtgaggagat tgtttatttt ttaattcttt tgtttaccga acgtttactg     6000

agcatctacc ctgtgccagc cctactcgta cgctctgtct ccaaagatga aaaaggactt     6060

ctctgccctc aagggaaccc cacagtatct tagaggagac aatcatgtcg gtgagatggt     6120

gtggtgatga agcctgctgg gtatacagct cagggaaagt catcgatgat ggctcaggct     6180

cagcctgggc acgccccaga ggagagagat ggagtggggc ctcaaagggc aggtttaggc     6240

agaaaagaaa aagggcattc cagctggggc atgtgcaaag gcagcacgta atgtgtaagt     6300

tctagatcgt cagggaggaa gggtcagttg ggtgcctgtt tttctgtttt tagtccttta     6360

aaatgagtag aagcaacctg ttaccctgga aagagcactg gacatagacc tagtgctgcg     6420

tgatgttgag cacgtttctt cttccctttg agtcccagtt tcccttttgg ttacaggggg     6480

atagtagccc ccagggatca tgtgaaagtg agaaagccct tttcacactg tggagcggtg     6540

cagatgtggg aaacctcaaa gatggttgcc cattttaaat cctttcatct ctcatctctc     6600

tttcttctct cccttctgcc ctgacgtagc catggttggg tgggtgaggc cagaagaaac     6660

tgcctccggc aagaggtagc agccgctcag gtggctctgc tggcatcgga gcccacagaa     6720

gtgaggagtg gccgatggac ctgccctcca aatgtgcctg actctgggtc ttgctgtcac     6780

tggatttcct ggcatggcag acagaaagaa agatagtttg accaagtcgt agaagctgat     6840

ccagcgggta aaaagggggc agggaactcg tcccttttat tcttgcctca gagctgcctg     6900

aagacatggg ccaggccgga ggctggacaa ctttggataa cgctgacctg tacttccaag     6960

taaatgcctc ctgaagagcc cgggaccctt cctgggagaa ttctgcagcc agaatgaagg     7020

tgccatcagc aggaggcact gtgaagcacc atcctgtcgc tgtccttgtc cattcctagc     7080

aagttaatcg tgtcttgtta accagcagtt cctgttcaac gtgtaaagag acctgatgtt     7140

ttccctaata aagctgataa caga                                            7164


<210> 1324
<211> 2624
<212> DNA
<213> Homo sapiens

<400> 1324
tttgttgttg acaactgtca gcttcgacct ccttctcctc acaaccccgt ctaaatgggg       60

tttgtaatcc tccttcccac ccactctctt cactccctgg ggcaagaatg ttgactcctg      120

ctctccgtca cctgtcagga tccatcctcc tgtcactggc ttatatggac acgtcagccc      180

accgtcacgt gaccgcaggc tgctaaaaac agctccagca cccactccaa accagggcct      240

gaaacaatgt cctccaccga gagaaacgta aaggacactt gatcacacaa tccctggaat      300

aatatccagg aaacacttgc tggagccact cgcagcaccc ttccctggca gcacacttgg      360

ggacagcgag gagatgagcg catctctgaa ttacaaatct ttttccaaag agcagcagac      420

catggataac ttagagaagc aactcatctg tcccatctgc ttagagatgt tcacgaaacc      480

tgtggtgatt ctcccttgtc agcacaacct gtgtaggaaa tgtgccagtg atattttcca      540

ggcctctaac ccgtatttgc ccacaagagg aggtaccacc atggcatcag ggggccgatt      600

ccgctgccca tcctgtagac atgaagtggt tttggataga catggggtat atggacttca      660

gaggaacctg ctggtggaaa atatcattga catctacaag caggagtcca ccaggccaga      720

aaagaaatcc gaccagccca tgtgcgagga acatgaagag gagcgcatca acatctactg      780

tctgaactgc gaagtaccca cctgctctct gtgcaaggtg tttggtgcac acaaagactg      840

ccaggtggct cccctcactc atgtgttcca gagacagaag tctgagctca gtgatggcat      900

cgccatcctc gtgggcagca acgatcgagt ccagggagtg atcagccagc tggaagacac      960

ctgcaaaact atcgaggaat gttgcagaaa acagaaacaa gagctttgtg agaagtttga     1020

ttacctgtat ggcattttgg aggagaggaa gaatgaaatg acccaagtca ttacccgaac     1080

ccaagaggag aaactggaac atgtccgtgc tctgatcaaa aagtattctg atcatttgga     1140

gaacgtctca aagttggttg agtcaggaat tcagtttatg gatgagccag aaatggcagt     1200

gtttctgcag aatgccaaaa ccctgctaaa aaaaatctcg gaagcatcaa aggcatttca     1260

gatggagaaa atagaacatg gctatgagaa catgaaccac ttcacagtca acctcaatag     1320

agaagaaaag ataatacgtg aaattgactt ttacagagaa gatgaagatg aagaagaaga     1380

agaaggcgga gaaggagaaa aagaaggaga aggagaagtg ggaggagaag cagtagaagt     1440

ggaagaggta gaaaatgttc aaacagagtt tccaggagaa gatgaaaacc cagaaaaagc     1500

ttcagagctc tctcaggtgg agctgcaggc tgcccctggg gcacttccag tttcctctcc     1560

agagccacct ccagccctgc cacctgctgc ggatgcccct gtgacacaga ttggatttga     1620

ggctcctccc ctccagggac aggctgcagc tccagcgagt ggcagtggag ctgattctga     1680

gccagctcgc catatcttct ccttttcctg gttgaactcc ctaaatgaat gatattcatt     1740

ccaactgctg cccctctgtc tgcctggctg agatgcatgt gggcagcagg aagcccaagt     1800

gaaattaata ttatgcagat gatgaaaggg acctctgaac aggatttctg caaaaatagc     1860

cccaaactgc aattccatat gacttatcta acatcttggg gggaaagaat attttgagaa     1920

aatagttgca gaaagcactg gaaataataa acttgatctt atacaaatct tctattgtgt     1980

ggaaaatgtt gtgaagggtg tgtaggtgtg gtacatgtgt atgtcactaa caagtggcaa     2040

atggtgaaaa aagtggtcac tatgcttttg tctctcatag gcactgactt tttgttatta     2100

tattatggta gctttcattt cctttactct ttaacagtgc aggtggtcag tgaaaatcag     2160

tgtcaactca gaagtgactg atttatcaat acatggacaa aaagtaaatc attgaccaaa     2220

gctatgaaat gtttcacaaa gttttcctct tttgcataac agatgtcact ggatgtacat     2280

tcagaaatgt tctttgaatt tggtgacact ttcatggtcc agaaagctga aggcctgggc     2340

atctcttgtg acatttttct aatattagtt ttagattttc acgtattagg cactttagtt     2400

gaatcttcca gcaaaagctg tctactttct cttttattca ctgtggcacc aatctggtaa     2460

attgtagaac aattgcatgt gtttaaatat atatacaaac atatcacaca ttaaatatat     2520

atatatttaa atcatgcttt gttaatattt gtcccaccat aatgcctcct tcagaacata     2580

agtgtaactt tatatgaact cttaaataaa tgatgttttt aaaa                      2624


<210> 1325
<211> 2018
<212> DNA
<213> Homo sapiens

<400> 1325
agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg ccctctccta       60

taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg tttttctctt      120

ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct taacaccgaa      180

caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag ttgatgtgga      240

aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa tggatgatga      300

aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa aaaaggtcat      360

tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg agaacaaaga      420

aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg accaaggaac      480

actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc ttgatgttac      540

atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc gcaagacctt      600

caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag agaaccagtg      660

gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat tgttccaaat      720

actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga caaatgcagc      780

agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt gagcacagat      840

cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt tctttgctct      900

gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc tcttttttgt      960

aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta aaagttggca     1020

ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaacaaa atattatctt     1080

tattcatgag ttggaaactg gaaaaaggct tcttgaagta aatgttctga gtggagctac     1140

taggatgtct tccagcctcc tgcagtcaag gagtaccact gtattgatta gcctgtatgt     1200

agcagggctc ccttcattgc atctgaggac ttgttttctt tttctttatt tttaatcctc     1260

ttagttttaa atatattgcc tagagactca gttactaccc agtttgtggt tttttgggag     1320

aaatgtaact ggacagttag cttttcaatt aaaaagacac ttaacccatg tgggatgtca     1380

tctttttata attagtgttc ccatgtggag aaaattattc acactacttg catgtaaaga     1440

ataatttaac ttttaacatt aaaatatgtg gtaaaaccca gaaagcatcc atcatgaatg     1500

caagatactt tcaataaaaa gtaagttata tagtaggtag ttaagtttgc ttttgtggac     1560

ttaaatgtgt ctcttcactt aaatgggttg aatgtgtata tatttgttca gcttgaaaag     1620

acttagttta tatcctagct cactggaggc tgctgacata accataactt ctgtcccttc     1680

taattgtcat ttatatgcct aactggagct agtactttaa ttcttaacac aaaattactc     1740

tgccattgtt tccagcttcc ctcctacaat agaatgaagt ttttttgatg gcttgagatg     1800

gctcacaaat tttgattttt ttttcttcct tgtgctccct ttttttctcc ttgcttttcc     1860

agttaacatc tatattcaca tgtaatcttg ttttctcttc acattcactg agttgttcag     1920

gctcagatca tcccttgaca gtagtttgcc ttcatctcac ctttcatttg tcccaaattc     1980

accttattta ataaagtccc atatgttgtc tcacttaa                             2018


<210> 1326
<211> 3742
<212> DNA
<213> Homo sapiens

<400> 1326
ggccgtgcga gaggccgagc ttgctgcatt gcagccgccg cggcgccgct cggctcttca       60

ctcccaacaa tggcggctcc gagcccgagc ggcggcggcg gctccggggg cggcagcggc      120

agcggcaccc ccggccccgt agggtccccg gcgccaggcc acccggccgt cagcagcatg      180

cagggtaaac gcaaagcact gaagttgaat tttgcaaatc cacctttcaa atctacagca      240

aggtttactc tgaatcccaa tcctacagga gttcaaaacc cacacataga gagactgaga      300

acacacagca ttgagtcatc aggaaaactg aagatctccc ctgaacaaca ctgggatttc      360

actgcagagg acttgaaaga ccttggagaa attggacgag gagcttatgg ttctgtcaac      420

aaaatggtcc acaaaccaag tgggcaaata atggcagtta aaagaattcg gtcaacagtg      480

gatgaaaaag aacaaaaaca acttcttatg gatttggatg tagtaatgcg gagtagtgat      540

tgcccataca ttgttcagtt ttatggtgca ctcttcagag agggtgactg ttggatctgt      600

atggaactca tgtctacctc gtttgataag ttttacaaat atgtatatag tgtattagat      660

gatgttattc cagaagaaat tttaggcaaa atcactttag caactgtgaa agcactaaac      720

cacttaaaag aaaacttgaa aattattcac agagatatca aaccttccaa tattcttctg      780

gacagaagtg gaaatattaa gctctgtgac ttcggcatca gtggacagct tgtggactct      840

attgccaaga caagagatgc tggctgtagg ccatacatgg cacctgaaag aatagaccca      900

agcgcatcac gacaaggata tgatgtccgc tctgatgtct ggagtttggg gatcacattg      960

tatgagttgg ccacaggccg atttccttat ccaaagtgga atagtgtatt tgatcaacta     1020

acacaagtcg tgaaaggaga tcctccgcag ctgagtaatt ctgaggaaag ggaattctcc     1080

ccgagtttca tcaactttgt caacttgtgc cttacgaagg atgaatccaa aaggccaaag     1140

tataaagagc ttctgaaaca tccctttatt ttgatgtatg aagaacgtgc cgttgaggtc     1200

gcatgctatg tttgtaaaat cctggatcaa atgccagcta ctcccagctc tcccatgtat     1260

gtcgattgat atcgctgcta catcagactc tagaaaaaag ggctgagagg aagcaagacg     1320

taaagaattt tcatcccgta tcacagtgtt tttattgctc gcccagacac catgtgcaat     1380

aagattggtg ttcgtttcca tcatgtctgt atactcctgt cacctagaac gtgcatcctt     1440

gtaatacctg attgatcaca cagtgttagt gctggtcaga gagacctcat cctgctcttt     1500

tgtgatgaac atattcatga aatgtggaag tcagtacgat caagttgttg actgtgatta     1560

gatcacatct taaattcatt tctagactca aaacctggag atgcagctac tggaatggtg     1620

ttttgtcaga cttccaaatc ctggaaggac acagtgatga atgtactatg tctgaacata     1680

gaaactcggg cttgagtgag aagagcttgc acagccaacg agacacattg ccttctggag     1740

ctgggagaca aaggaggaat ttactttctt caccaagtgc aatagattac tgatgtgata     1800

ttctgttgct ttacagttac agttgatgtt tggggatcga tgtgctcagc caaatttcct     1860

gtttgaaata tcatgttaaa ttagaatgaa tttatcttta ccaaaaacca tgttgcgttc     1920

aaagaggtga acattaaaat atagagacag gacagaatgt gttcttttct cctttaccag     1980

tcctattttt caatgggaag actcaggagt ctgccacttg tcaaagaagg tgctgatcct     2040

aagaattttt cattctcaga attcggtgtg ctgccaactt gatgttccac ctgccacaaa     2100

ccaccaggac tgaaagaaga aaacagtaca gaaggcaaag tttacagatg tttttaattc     2160

tagtatttta tctggaacaa cttgtagcag ctatatattt ccccttggtc ccaagcctga     2220

tactttagcc atcataactc actaacaggg agaagtagct agtagcaatg tgccttgatt     2280

gattagataa agatttctag taggcagcaa aagaccaaat ctcagttgtt tgcttcttgc     2340

catcactggt ccaggtcttc agtttccgaa tctctttccc ttcccctgtg gtctattgtc     2400

gctatgtgac ttgcgcttaa tccaatattt tgcctttttt ctatatcaaa aaacctttac     2460

agttagcagg gatgttcctt accaaggatt tttagcccca aatctctcat attcgctagt     2520

gtttaaaagg ctaagaatag tggggcccag ccgatgtggt aggtgataaa gaggcatctt     2580

ttctagagac acattggacc agatgaggat ccgaaacggc agcctttacg ttcatcacct     2640

gctagaacct ctcgtagtcc atcaccattt cttggcattg gaattctact ggaaaaaaat     2700

acaaaaagca aaacaaaacc ctcagcactg ttacaagagg ccatttaagt atcttgtgct     2760

tcttcactta cccattagcc aggttctcat taggttttgc ttgggcctcc ctggcactga     2820

accttaggct ttgtatgaca gtgaagcagc actgtgagtg gttcaagcac actggaatat     2880

aaaacagtca tggcctgaga tgcaggtgat gccattacag aaccaaatcg tggcacgtat     2940

tgctgtgtct cctctcagag tgacagtcat aaatactgtc aaacaataaa gggagaatgg     3000

tgctgtttaa agtcacatcc ctgtaaattg cagaattcaa aagtgattat ctctttgatc     3060

tacttgcctc atttccctat cttctccccc acggtatcct aaactttaga cttcccactg     3120

ttctgaaagg agacattgct ctatgtctgc cttcgaccac agcaagccat catcctccat     3180

tgctcccggg gactcaagag gaatctgttt ctctgctgtc aacttcccat ctggctcagc     3240

atagggtcac tttgccatta tgcaaatgga gataaaagca attctgactg tccaggagct     3300

aatctgaccg ttctattgtg tggatgacca cataagaagg caattttagt gtattaatca     3360

tagattatta taaactataa acttaagggc aaggagttta ttacaatgta tctttattaa     3420

aacaaaaggg tgtatagtgt tcacaaactg tgaaaatagt gtaagaactg tacattgtga     3480

gctctggtta tttttctctt gtaccataga aaaatgtata aaaattatca aaaagctaat     3540

gtgcagggat attgccttat ttgtctgtaa aaaatggagc tcagtaacat aactgcttct     3600

tggagctttg gaatatttta tcctgtattc ttgtttgaat tcctcctcta tttaagatat     3660

atacatggaa tcgaagtgtt tatgtaatag ttctatcctt ttgcctgcag gtcagttgta     3720

ataaatctag gatgtgatga tg                                              3742


<210> 1327
<211> 3091
<212> DNA
<213> Homo sapiens

<400> 1327
acttccggct tcgctgctct tggttctggt tctggaggct gggttgagag gtcgccggtc       60

cgactgtcct cggcggttgg tcagtgtgaa tttgtgacag ctgcagttgc tccccgcccc      120

cgagcagccg aggtgcgtgg gggaagggga agaaggaaaa ggtccgggtc gcgtttccgc      180

tcagtttttg ccagggttga ggcgattcca gagagcggcg gaaaggataa gcctcgactt      240

agaagctacc gagttaccct aagaaaggag tctaccatgg ctcaagaatc tcccaaaaat      300

tcagcagcag aaattccagt gactagtaat ggagaagttg atgactctcg tgaacatagc      360

tttaataggg atttgaagca ttcattacca tctggacttg gtctctcaga aacccaaatt      420

acatctcatg gctttgacaa taccaaagag ggtgttattg aagcaggagc atttcaaggt      480

tccccagcac cgccactgcc atctgttatg tctcctagca gggttgcagc tagtcgactg      540

gctcagcaag gaagtgattt aattgttcct gcaggtggcc agagaacaca gacaaaaagt      600

ggaccagtta ttctagcaga tgaaattaaa aatcctgcaa tggaaaagtt agaacttgtt      660

agaaaatgga gtctaaacac ctataagtgt actcgacaga ttatctctga gaagctaggc      720

cgtggctcaa gaactgtgga ccttgaactt gaagctcaga ttgatatatt aagggataac      780

aagaaaaaat atgaaaatat tttaaaactg gctcaaacat tgtcgaccca gcttttccag      840

atggtacata cccaaaggca acttggagat gcatttgctg acctgagttt gaagtcacta      900

gaacttcatg aagaatttgg ctataatgcc gatacccaga aactgctggc taaaaatgga      960

gagactcttc ttggggccat taattttttc attgctagtg tgaacacttt ggtgaataaa     1020

accattgaag atacattaat gactgtgaaa cagtatgaaa gtgccaggat tgaatatgat     1080

gcatatcgca ctgatttgga agaactgaat cttggaccac gtgacgcaaa cactctgcca     1140

aagattgagc agtcacagca tctcttccaa gcacataagg aaaaatatga taaaatgcgc     1200

aatgatgttt ctgtcaaatt gaaatttcta gaagaaaata aggttaaagt attgcacaat     1260

cagctggtcc ttttccacaa tgccattgcc gcttactttg ctgggaatca gaagcagctt     1320

gaacagacac ttaaacagtt ccatatcaaa ttgaaaaccc ctggagtgga tgccccatct     1380

tggcttgaag aacagtaaaa tcacagcgga aaataaaaag aaagtcgcgt tgttatattt     1440

ctaaaccaac ctaacaagaa ttaagcagag ttgggggaag tgggaggggt gacaagcatt     1500

atagtgattc ttgcacaaac agctttaatt tttccctttt tcatacttta acaattgaac     1560

tgttaagggt ggttttaatg taaacatagt ttctataatc tgaacacaat aattttcctt     1620

tttgagaaat ccttttgtat tgtgagggtt gatggctatt tctgtagttt gaaaacatct     1680

aatagagatt tgcactgaca agataaaaat tcaaggtttt tggtcctgga aatgagggcc     1740

gattgtaact tttccaaagg gaggtttaca tgatttgtat caacatcaga tattttatat     1800

gtgaatatat taaacatctt taagagattc attttcatgt attaaagaaa aaagaaacta     1860

ttttgcagag taaagttata tggtgttcct gcagcgtcca cacagaggca gcagctctaa     1920

tgaatgatta gcttgtggag ttgtggcaaa taccttttta aaaatgaatc tgtaccactg     1980

taattttatt tagacttttt tttaaagaca cagaaatcac actgtcattt ctgtgaggct     2040

tttaagctta tgaatttgct tcacccgaag tcattggaca gttacatttg caatttcttt     2100

tggttcataa caaaacctgc ttaagagaat tttttttttt gacaggtgga cgtgggaatg     2160

gaaattctta atggtttctg gagtagaaat ctgtacttag aaaactagtt tttgggtcag     2220

ttccattttg atagaagtga atacatagac agcttttatt gacttccata tgtaacaata     2280

ccgtttaagc cttaaatcac agatatgtgc cttctcagat acagtaattc ttgttcaacc     2340

aatgtacaaa atccataaag aaacccctgt tggataatgt ttgatgtgtc tattccttcc     2400

atggaatgga gcactatgta tgaatgttgg gtttctttgt acttgttaag ccacatttga     2460

ggtttatggt aaaaatcatc ttttgagttt gctctttggt ttttcttcat tccttttgag     2520

gattgggaaa acagaaagat tctttgattt gggtaatgaa gaggtaattt gggacagtgt     2580

ggtggtacca ggaagaaaga ggattggaaa ggccagtact gttttagttg ctcggcactg     2640

ttggttttgt tttaatgtgg ttgccctgtc cactacatgg ttctatcagt agtgtaatcc     2700

attttcaatg taaagctctt ttagtttttg tcatagacat aaattaatat tttgagaggc     2760

atccctcacc tgttcatttc ttctgtgttg aaatgaagta cttaaaatta ccgttataca     2820

tgaactttgt ggactgtaag atttgttata tatgttcaaa tgccttttag ctggcttttt     2880

aattaatatg cctgttttga gtgcttaata caatgtaatg tgattgtaaa tcatacctat     2940

tttaaatcat tccttcctgt atatttgtac tcagagagcc ttattttatt cttccagcag     3000

aattactact tgtgatagtt catttacatt ccccagaatg tgcctctagt gtgaattttg     3060

tattcttatt aaacgtgttt gctgcagtaa a                                    3091


<210> 1328
<211> 5176
<212> DNA
<213> Homo sapiens

<400> 1328
tgggataaac ggagctggac gactcagtct cttggtctgt ggctgctgcg gttacctgga       60

tgggcgagca cctctgaggc tggctttgtt acctgggcaa taagggacta gcagttcagc      120

cgttttctat gcctgctgga tttgtttgta tttgttccca gccactgctc atgtaatgta      180

ctcccttaac caggaaatta aagcattctc ccggaataat ctcaggaagc aatgcaccag      240

ggtgacaacg ctaactggaa agaaaattat agaaacatgg aaagatgcca gaattcatgt      300

tgtggaagaa gtagagccga gcagtggggg tggttgtggt tatgtgcagg accttagctc      360

ggacctgcaa gttggcgtta ttaagccatg gttgctccta gggtcacaag atgctgctca      420

tgatttggat acactgaaaa agaataaggt gactcatatt cttaatgttg catatggagt      480

tgaaaatgct ttcctcagtg actttacata taagagcatt tctatattgg atctgcctga      540

aaccaacatc ctgtcttatt ttccagaatg ttttgaattt attgaagaag caaaaagaaa      600

agatggagtg gttcttgttc attgtaatgc aggcgtttcc agggctgctg caattgtaat      660

aggtttcctg atgaattctg aacaaacctc atttaccagt gctttttctt tggtgaaaaa      720

tgcaagacct tccatatgtc caaattctgg cttcatggag cagcttcgta catatcaaga      780

gggcaaagaa agcaataagt gtgacagaat acaggagaac agttcatgag ttgcattgta      840

gcagacaatg gacaactgta gtttctgaat tgacttctat agccatcttt tccctttttt      900

ggagagtaga ctagcaaaac tccctttttt ctcttgcctt ttttatgcat aaatggaggt      960

caatttgatt gtcctgacct actgtataag taaatttcaa atgtcattac tttctctttg     1020

ttattataat gtgtgattaa atgctttttt aaattgctaa gggaaaataa caaagtgtta     1080

gtaatcattg ctttctgtag aagaaaaagg tttaaattta aaatgtgtat ttagagcatg     1140

gagagaatca tttaatgaag cctatttttc tgttccagca actgttttta tgaaagaaaa     1200

acttgaaatg ctacttaact tactatttca aagggaagta tatttctttt taaagaatct     1260

ttttaagatt aaaaatgaat accttaaatc tcccaaaaga gataaccagt atctgaaggt     1320

ttatacaata tttacacagt ggctacaata ttcacaaaat tcttatgttc tcttatgaaa     1380

aatatacact tttcattttg tcttcttctt tttttttctt tttttagatg gagtttggct     1440

cttgtcaccc aggctggagt gcaatggcgc aatctcagct cactgcaacc tctgcctccc     1500

gggttcaagc gattctcctg ccccagcctc ccatatagct gggattatag gtgcctgcca     1560

ccatgcccag ctaatttttg tgtttttagt agagatggag tctcaccaca taggccaggc     1620

agtctcgaac tcctgacctc aggtgatcca cccaccttgg cctctctaaa tactgggatt     1680

acaggcgtga gccactgcat ccgacctcat tttgtttttt tcaattctgt tatcggcatt     1740

tctttctttt tttttttaat gtataggtgt tctgtcatac gttattgtga gctttggttc     1800

tttgaacagg tgatctattc tcttacattt tgtgcttttt atcttgggtg cctagcattc     1860

tgtttttttg atcctatgtc ataatttttt gagaaaatgt ttgatactgc aagatcattg     1920

tttagtggtc tgttttctac ttcagtattc taccagagaa catatttttt aggggagaag     1980

ggttatggtt ttgtaagaaa ctttaaatat acttttagga gacccacaat catttacagt     2040

tttatctttg gcctttgaat aggttctttt ttctttaatg tctccgtatt tgaagaactg     2100

agctctgtac attataaatt tgcttaaaga ttttgatttt ttcttcagaa tatggtatac     2160

ttaaaattaa ttaattaaga cagtttcttt tttcttttct tttttttttt tttcgagaca     2220

gggtcttgct ctgtcaccta ggctagagtg gagtggcatg aacacaacgc actgcagcct     2280

ctacctcctg ggctcaagca gtcctcccac ctcagtctcc tgagtagctg agactacagc     2340

tgtgcgccac cacatctggc taattttatt tttatttttg tagagacagg agtcttgcca     2400

tgttgcccag gctgatctca aactcctagg cttaagtgat cctcccgcct tagcctccca     2460

agtgctagga ttacaggcat cagccaccac gcctggcctg atagtttcca catagttttt     2520

catgacttag aagatatcat tgccatgtag gttttatttt taaaagtctt gagctcttct     2580

taaatataca ttataaagag caagcataga tggaaagtgc atattgaaca catctgtgca     2640

tttgagaagg caggctttca tatgctgtca tgagcaaaaa gtagaagtga taaatgcaag     2700

ttatgttttg agattgctta caccgtgaca agatgccatc acttgtgatg ttatgaactg     2760

ttataaactc tttgcttctg ctaagaagca gtctaaatat aatcaacgta cagtgagctc     2820

tttgaagcca accaaggcag gcagaaccct cttaaatatg agactgatgt ataggttctc     2880

tctatggtca gtatcactgg ataagccttc tcctttcata agaaaggatg tatttaaata     2940

cattttattt tgctaaatcc tgtttagttt tcagccatta aatgtcacat gaagccttga     3000

tagaatttgt tcataatggc tcatgtatta ttattatttt tgagatggag ttttgctctt     3060

aatgatatta ttattatttg agacagagtt ttgctcttat tgcccaggct ggagtgcagt     3120

ggcgtgatct tggctcactg caacctctgc ctcccagctt caagcgattc tcctgtatca     3180

gcctcccaag tagctgggat tataggcatg tgccaccatg cccagcaaat tttgtatttt     3240

tttttggtag agacagggtt caaccatgtt ggtcaggctg gtctcgaact cctgaccgca     3300

agtgatccac acgccttggt ctcccaaagt gctgggatta cggtgttagc cactacacct     3360

ggcctggatt gtgtattatt tatgtctgta gtttatatgc ttagttgttg cctatagtga     3420

tctgggtaag attcaaacat ttatcttttg tatcttctac agaagtgctt tgagcatcaa     3480

atttgtttta acgttaaatt gtagtttgct gtattaaaat agatcaatga atataattca     3540

gtcttttagg ggcaccaagt aaagcataag gtcatatata ctatacaata tgtttattgc     3600

acttcccatg gggataaatc actctgtcat tcctagttat tttaaaaaaa gaactttatg     3660

attacggtcc tctttctcac atactgcaaa cttaaaagat acatacacca aatataggtc     3720

tgttttaaag gagaggaaaa atagttcaag gagtttttgc ctctttgttt ttcaatagat     3780

tattctgcca ttttttaaag gaaagggaaa atgaaaacag catgtctttt taaacattga     3840

aaagaaatat ggaggcttta aaccgcaaac tgaaaaagct gagtagaaca aaggcagtgg     3900

agcatacaat acaattctat ttatttgagg ttaattgaag ttaataattt ttaaattttt     3960

ttctaatttt atgccttaaa ataggtttct gattacataa aatttgaata gaacactcaa     4020

gaagtatgta gatttttgaa aaacccaaac aatattcttc ttagattttt ggaggcaaaa     4080

tttagaccag tatactaatt caaaagacaa atatttcaga ggaagtggag tacagtattt     4140

aacattttgt ttgcaatttt actttttctt cccttcttcc ctattgaacc ttgattaaaa     4200

tgtatgaata caatacttgg attttttttt ttcagcttag actctgataa tttcagtggt     4260

agtggggaaa cctgaatttg tcagcatgat tatttgtaac tcagattgtt caaatgtata     4320

tagaaggtcc ccttcaagtg ttgtttctcc aagtagtcat aaatgtagca agtataaatc     4380

agaatatcat cttataatct tacagagtta acctaatgag tcaatacctt tataagcaaa     4440

accatgataa atttaaaaac aacagaaatg tggcatgatt acttatttat ttgttccagg     4500

tgactctaaa tagttgattt ttctgcctga aggatcctga acatatttag ttaccctgta     4560

gttatttagg aatttaaacc agaagacttt gaagttgtat attcttgcaa tgcataaaat     4620

gacattataa tcaacaaact tatggtttgt ttcaattgat gcacacaaaa aataacttat     4680

agttagactt ttctatttca agtaaagctt tgagttactt gtttttatac atattcatca     4740

tgtacccttt attgtttcta ggtgttgata tactttaata aaaatgatat gtttaatatt     4800

ttcccattaa tatatttctt tgaagctatt tgttttaaaa gatgtaacac ttatttgctg     4860

tcaaattctg aattaaaaaa tctgttggtg gccaggcgca gtggctcatg cctgtaatcc     4920

caacattttg ggaggccaag gagatggatc acttgaggcc aggagttcaa gaccagcctg     4980

gccaacatgg caaaacccca tcactaaaaa tacaaaaatt acccgggcat ggtggtgggt     5040

gcctgtaatc ccagcttctt aggaggctga ggtaggagaa ttgcttgacc ctgggaggtg     5100

gaggtggcag tgagccgaga tagcaccact gcacttctag ttgacagagt gagactctga     5160

ctcaaaaaaa aaaaaa                                                     5176


<210> 1329
<211> 3345
<212> DNA
<213> Homo sapiens

<400> 1329
attggtgagt ggggcagggc aggagggaac tgaagagtga gaaagcatta tttcagcaaa       60

aggtctttcc tcccttgctc tctcctccaa ccactggctc agcctctccg cccgctgcct      120

gtgaatgatg caatggaagg tgtgctgggg tcgccctgtg tcccgtgcat aggagcatct      180

cagcctccag gtcctctcct ttggggctca cggcaccccc atgctacgaa ccgcaggcag      240

ggacggcctc tgtcgcctgt ccacctactt ggaagaactc gaggctgtgg aactgaagaa      300

gttcaagtta tacctgggga ccgcgacaga gctgggagaa ggcaagatcc cctggggaag      360

catggagaag gccggtcccc tggaaatggc ccagctgctc atcacccact tcgggccaga      420

ggaggcctgg aggttggctc tcagcacctt tgagcggata aacaggaagg acctgtggga      480

gagaggacag agagaggacc tggtgaggga taccccacct ggtggcccgt cctcacttgg      540

gaaccagtca acatgccttc tggaagtctc tcttgtcact ccaagaaaag atccccagga      600

aacctacagg gactatgtcc gcaggaaatt ccggctcatg gaagaccgca atgcgcgcct      660

aggggaatgt gtcaacctca gccaccggta cacccggctc ctgctggtga aggagcactc      720

aaaccccatg caggtccagc agcagcttct ggacacaggc cggggacacg cgaggaccgt      780

gggacaccag gctagcccca tcaagataga gaccctcttt gagccagacg aggagcgccc      840

cgagccaccg cgcaccgtgg tcatgcaagg cgcggcaggg ataggcaagt ccatgctggc      900

acacaaggtg atgctggact gggcggacgg gaagctcttc caaggcagat ttgattatct      960

cttctacatc aactgcaggg agatgaacca gagtgccacg gaatgcagca tgcaagacct     1020

catcttcagc tgctggcctg agcccagcgc gcctctccag gagctcatcc gagttcccga     1080

gcgcctcctt ttcatcatcg acggcttcga tgagctcaag ccttctttcc acgatcctca     1140

gggaccctgg tgcctctgct gggaggagaa acggcccacg gagctgcttc ttaacagctt     1200

aattcggaag aagctgctcc ctgagctatc tttgctcatc accacacggc ccacggcttt     1260

ggagaagctc caccgtctgc tggagcaccc caggcatgtg gagatcctgg gcttctctga     1320

ggcagaaagg aaggaatact tctacaagta tttccacaat gcagagcagg cgggccaagt     1380

cttcaattac gtgagggaca acgagcctct cttcaccatg tgcttcgtcc ccctggtgtg     1440

ctgggtggtg tgtacctgcc tccagcagca gctggagggt ggggggctgt tgagacagac     1500

gtccaggacc accactgcag tgtacatgct ctacctgctg agtctgatgc aacccaagcc     1560

gggggccccg cgcctccagc ccccacccaa ccagagaggg ttgtgctcct tggcggcaga     1620

tgggctctgg aatcagaaaa tcctatttga ggagcaggac ctccggaagc acggcctaga     1680

cggggaagac gtctctgcct tcctcaacat gaacatcttc cagaaggaca tcaactgtga     1740

gaggtactac agcttcatcc acttgagttt ccaggaattc tttgcagcta tgtactatat     1800

cctggacgag ggggagggcg gggcaggccc agaccaggac gtgaccaggc tgttgaccga     1860

gtacgcgttt tctgaaagga gcttcctggc actcaccagc cgcttcctgt ttggactcct     1920

gaacgaggag accaggagcc acctggagaa gagtctctgc tggaaggtct cgccgcacat     1980

caagatggac ctgttgcagt ggatccaaag caaagctcag agcgacggct ccaccctgca     2040

gcagggctcc ttggagttct tcagctgctt gtacgagatc caggaggagg agtttatcca     2100

gcaggccctg agccacttcc aggtgatcgt ggtcagcaac attgcctcca agatggagca     2160

catggtctcc tcgttctgtc tgaagcgctg caggagcgcc caggtgctgc acttgtatgg     2220

cgccacctac agcgcggacg gggaagaccg cgcgaggtgc tccgcaggag cgcacacgct     2280

gttggtgcag ctaccagaga ggaccgttct gctggacgcc tacagtgaac atctggcagc     2340

ggccctgtgc accaatccaa acctgataga gctgtctctg taccgaaatg ccctgggcag     2400

ccggggggtg aagctgctct gtcaaggact cagacacccc aactgcaaac ttcagaacct     2460

gaggctgaag aggtgccgca tctccagctc agcctgcgag gacctctctg cagctctcat     2520

agccaataag aatttgacaa ggatggatct cagtggcaac ggcgttggat tcccaggcat     2580

gatgctgctt tgcgagggcc tgcggcatcc ccagtgcagg ctgcagatga ttcagttgag     2640

gaagtgtcag ctggagtccg gggcttgtca ggagatggct tctgtgctcg gcaccaaccc     2700

acatctggtt gagttggacc tgacaggaaa tgcactggag gatttgggcc tgaggttact     2760

atgccaggga ctgaggcacc cagtctgcag actacggact ttgtgctgga tgttatttgg     2820

gatggacctg aataaaatga cccacagtag gttggcagcg cttcgagtaa caaaacctta     2880

tttggacatt ggctgctgaa tggtcctatc tgctggctct cccctgagat ctggacagag     2940

gaagatggga gggtgctcat caccccccca gcataatgat cagcctcctt cctagagaca     3000

gactcatgca gattgagatc aaaagtccct ctgcttggga tcaaattaat gtttgacaga     3060

gctggccagg cgtggtggct catgtatgta atcctagcac ttcgagaggc cgaggcaggt     3120

ggatcacgag gtcaggagtt tgagattagc ctggccaaga tggtgaaacc ctgtctctac     3180

taaaaataaa aaaaaattag ccaggcatgg tggcgggcac ctgtagtccc agctactcag     3240

gaggctgagg caggagaatc gcttgaaccc gggaggtgga ggttgcagtg agccgagatc     3300

gcgccactgc actccagcct gggcgacaga gtgggactcc atctc                     3345


<210> 1330
<211> 2803
<212> DNA
<213> Homo sapiens

<400> 1330
cgccgccgcg ggctcaagcg gggcggccgg gccagcgcgg ggcggcggcg ggcaggggcg       60

gcgagtgcgc gggcgctcgc cgccgccctt ctcggcgggc agcgcgcgag gaccaggccg      120

aggaggaagt ggcggcggcg gcggcgggac tgcgcgcccc agctccgatc cccgttccgc      180

gtccccgccg ccgggaggag gtgcccactc gctcgcggcg cgcgccggcc gccagactcg      240

gcctgtgggc gatttcctcc ggacccaggc tccccgcccg aggaggaaga tgcagacctt      300

tctgaaaggg aagagagttg gctactggct gagcgagaag aaaatcaaga agctgaattt      360

ccaggccttc gccgagctgt gcaggaagcg agggatggag gttgtgcagc tgaaccttag      420

ccggccgatc gaggagcagg gccccctgga cgtcatcatc cacaagctga ctgacgtcat      480

ccttgaagcc gaccagaatg atagccagtc cctggagctg gtgcacaggt tccaggagta      540

catcgatgcc caccctgaga ccatcgtcct ggacccgctc cctgccatca gaaccctgct      600

tgaccgctcc aagtcctatg agctcatccg gaagattgag gcctacatgg aagacgacag      660

gatctgctcg ccacccttca tggagctcac gagcctgtgc ggggatgaca ccatgcggct      720

gctggagaag aacggcttga ctttcccatt catttgcaaa accagagtgg ctcatggcac      780

caactctcac gagatggcta tcgtgttcaa ccaggagggc ctgaacgcca tccagccacc      840

ctgcgtggtc cagaatttca tcaaccacaa cgccgtcctg tacaaggtgt tcgtggttgg      900

cgagtcctac accgtggtcc agaggccctc actcaagaac ttctccgcag gcacatcaga      960

ccgtgagtcc atcttcttca acagccacaa cgtgtcaaag ccggagtcgt catcggtcct     1020

gacggagctg gacaagatcg agggcgtgtt cgagcggccg agcgacgagg tcatccggga     1080

gctctcccgg gccctgcggc aggcactggg cgtgtcactc ttcggcatcg acatcatcat     1140

caacaaccag acagggcagc acgccgtcat tgacatcaat gccttcccag gggactgcca     1200

agtgtgcttt atagaaggct ggaagaccga ctgaagtagg aagctgtcac atgtttgagc     1260

caactgagca aagcagctgt tgcctgccag acagccaccc caagaccaag ggagccagcc     1320

tgtcgtttgt ccttctagcc tggaagacca gttcttggct cttgggcact cacattggcc     1380

actggccaca actgctgaat ggcttcacta atgtccctgg ggtctgtatc tgccctctct     1440

tctattccct agaaactctg gccgggcatg gcggctcacg cctgtcatcc cagcacttag     1500

ggaggctgag gcaggtggat cacaaggtca agagatcgac accatcctgg ccaacatggt     1560

gaaaccccat ctctactaaa aatacaaaaa ttagctggac atggtggtgg gcgcctgtag     1620

tcccagctac ttgggaggct gaggcaggag aattgcttga actcgggagg cgtaggttgc     1680

agtgagccaa gatcgcacca ctgcactcca gcctggcaac agagcaagac tcctcaaaaa     1740

acaaacaaac aaacaaacaa actctgatca ttcacccggt gggatccccg gcagctcctt     1800

ctccttcccg agctgtggct catgggccat tggattcaga gaccttgagc tgggtgctgg     1860

ctgccctaaa ggagcacgac ccctccagcc tggtgaccgg gaggcagaga agtgcagctg     1920

tccttgacaa aggcccagcc tctgctgcct caggccagcc tggccacacc ccgatgccac     1980

agtcatctgc cccgcccagg cataagcctg actcaggtga tacaggcgag gcttctccca     2040

tgggtcctcc ccttgtgaga aagggtctgt gctgtgtacc ttctctctgc acagccattg     2100

tcagtgtggt ttggagtgag tgagcctccc gcactgctca ggggagagct ggtgagcatg     2160

actccatggc ctcctgctgg ttggggtctt cttctgattc tcacccgcag gagcacccag     2220

accccccctt ttcagaaatg attacatttt cccttcaaga gtcatctgtg acctggtggt     2280

gtggagggac tgtcccctcc tgcagcctgg ccgaccccct tcctccaggg ctgtgtggaa     2340

tcacctctca gaagctcact ctgaaaagcc actcacaggg atttcaccag gatgttgctg     2400

ttcctgccga cacctgggct ttgtgacaaa tgctgtttgc ttcaagctgt tcacaagcaa     2460

cttcaccaga atcccaagct ggttcgtact taatttgtgt acatacatat gcataatata     2520

catgaccatg tatgagatac agacaccatg gcttctgtcc attggctcat tcgcctggtc     2580

gcatgttcac tccatgaggt taggacactg cgggtggctt tgggatgggt ggtttcaggg     2640

acaaggtgtc gctatgatct ctgtatttgc taactagtct tgttttgatt tctaacggtc     2700

tagtggagta cagttaatgt tgtgtttatt tctgtaactg taggggtgga gtataaacct     2760

aacttttgga aacatgaaga aataaacaat agcgccagcc gtt                       2803


<210> 1331
<211> 4007
<212> DNA
<213> Homo sapiens

<400> 1331
attccctctg gctgcggttc cgagaatagc ctggaaggag gcaggggtcc cggctggaga       60

agcgtggctc cggggtgggg cgtgcagggc tagcccgggc gggggacgct gcccaacaag      120

caggtttgcg gagactcaca ccttagattc tgagttttta agcttgtttc ctcagagcag      180

ggaactcacg aacgtttcgt gagcacctac ggtatgcagg gtacggtgcg gagccctagc      240

gtcactgacg accgggacag ccgagcagct gcaggatccg tcgtgttccc cagcaatttt      300

aatatttaaa aattcgttac tgttgctgtt acttgttttc tatgtattgg atgtcttcgt      360

gaagaaccct caaaagtgca acgaactcct ccctgccaga gggcggccgc gcgctctgag      420

tacagcttcc cgcggagccg gccaggtcct ccagggcacc gagaaagccg gccagaacgg      480

cggcgcccta tcccggccgc agcgatgtct gacggcgccc cggaactgac ggtctggtac      540

gcaggggcgc tcggcggcaa cggcggcttt aaacgtcatc gcgggcgcga cgcctgaggg      600

acagtctggg gtttggctgt ccggacggtg cagcggcgag gccggccgcg aagatgccag      660

tggcggtgat ggcggaaagc gcctttagtt tcaaaaagtt gctggatcag tgcgagaacc      720

aggagctcga ggcccctgga ggaattgcta cacccccagt gtatggtcag cttctagctt      780

tatatttgct ccataatgac atgaataatg caagatatct ttggaaaaga ataccacctg      840

ctataaaatc tgcaaattct gaacttgggg gaatttggtc agtaggacaa agaatctggc      900

agagagattt ccctgggatc tatacaacca tcaacgctca ccagtggtct gagacggtcc      960

agccaattat ggaagcactt agagatgcaa caaggagacg cgcctttgcc ctggtctctc     1020

aagcgtatac ttcaatcatc gccgatgatt ttgcagcctt tgttggactt cctgtagaag     1080

aggctgtgaa aggcatatta gaacaaggat ggcaagctga ttccaccaca agaatggttc     1140

tgcccagaaa gccagttgca ggggccctgg atgtttcctt taacaagttt attcccttat     1200

cagagcctgc tccagttccc ccaataccca atgaacagca gttagccaga ctgacggatt     1260

atgtggcttt ccttgaaaac tgatttatca ctctgagttc aagattcatc ttcagaatcc     1320

tgtatactga caaacgtaga aatgtaaagt ttgtattttc aatttattgg atggcttaag     1380

cacctcagca ttccttacta tgtgataaaa tacatataga atataagata tactatatac     1440

attttgtcca taaacgttat gctgaatagt tgttgaaaca gttctcattt tgtagtattt     1500

aataatctgg atggagcctg tcagtattac agttagtttt ctagtgactc ataaaataag     1560

atttcctgtt tcatgtagaa tagtgtttgt caactgtctt ttctctgtcc cagcacatgc     1620

cgtactctta tatgtaccat tggttgataa ttataatgat tcatttggac ttgaagaaag     1680

attgtcccca ggcacagtat ctgaatcact ggggattatg attcaccctc tttggagaac     1740

atgctctctt ttcacccccc acctcctgag agccactaat gtaagataca gaaacatagc     1800

tgaggaacaa atagaccatt tccatactaa accagtttgt taactttaga ttttttccaa     1860

tagtgtgagt atatccattg ctggcagtgg agggcttgcc atgaaaatgc aacttattta     1920

agacatttat gagacatatt aacttgtgct gtcgcctttt agaaggagaa acttaagtgt     1980

ggaatgcatt atatgggcaa agaagctatg aagatacatg atacactttg tacaactatc     2040

ctgcagccca ttggttgctt atatttatcg cttggctcaa gttctgccct ttggagaaat     2100

actgagcaag tctttcattc tctgtgtgac agccctctga atatttgaag ttgtttgttg     2160

taacttaagg ttataacagc ccttagttca tttactctgc atttgttcaa taaatattta     2220

actgaattct tcaattattt catctaagat agtttctgga aatttcactc tcgatctttc     2280

tgtggacaca atctattttg tcattgtgtc tatatgaatc tcttaagtag aaatgagttg     2340

tatggtgaat ctgtgtagtg ataattatat aatttattta ttttgaatgc attttagtgg     2400

ctatttcagt ttttcttaac atatatggga atactttttg aattgcaatt ttatttaacc     2460

cggataggta agtcatatta aaattccttg ttttacagtt gaggaaatgg gaattcaaga     2520

agtcagagga tcaggagagt gatcaagaga atgacagtgc cagttttttt aacttccagg     2580

tattaagtac aaattgtatc catggttatt ttttaaaagc agattagagt caatccaaat     2640

attcattaat aggggattgt ttgaataaac agcagtgtag actacgcagg tgtaaaagga     2700

gtgaagatct ctatactaaa ctggaatgat ctccagagtg agaacataga aagcacatgt     2760

agtttatatg gttattttga gggtaacaaa aggagaatga ttacaattat atatatgtac     2820

atatttcctt atatttcaaa actaagcaat tgggggatat atacaaaatg aatataatag     2880

ttccctaaag aggaaggaga ggacagtgaa ctactacata gagaaaaaat aatctcaagt     2940

gatcaaacac aatatttcaa ttttacattg tcagtgggat atacactaag gacagaaaaa     3000

aatcttagac taatgaatgt ggtttttcat gattaatttc acaaaatctt gatatctttt     3060

ttattattaa aagtatagat taaattaata atcatgtaac attagacccc agtaatctta     3120

aatttgacat ggaaacctca ttatatgctt tatttttctt tgtaaacagt aaatatttcc     3180

cactcctgtc tacatgaaaa ggtctagagt aattacagtt cagtaacaat gagcaccact     3240

agtacccaga tggtgttctt tcattttcat ttgcaattaa aaggaatcag aacttatttg     3300

caaaacagct aatagttcca gggcagtaag tgtacaagtt catatctggt acaagatgtc     3360

caggattcaa ggaggctctt aaagacttgg gattctgtca aagggttata caagccaact     3420

tgaagggatt tctacaggcc atgtaaaaat gagacagttt gagcatgaaa tatttgtata     3480

tgtgtctgtt tttaactctt aataacctca tcactgtaca agaaaggcag ggtaagtgct     3540

tgatttcact tccctttatt atcagttctc aggacaaatt gatatgctgc caatctctaa     3600

agcaacaaaa tcgaacctgt agggtagtca aaaagctcat gctggaaaat tccaccgaat     3660

aaagataaaa gttagaaaaa cggtacttgc agcccttaat gaaacaaaga agggatcatg     3720

gaaatatata tcaatgctgt tgagaccaca gggtaagaaa ttgagattga gcatgaaata     3780

tgtccagtac atccatcagc ctgtctttgt gctctggcta tttctgagcc agccatctgt     3840

gtacaagtgt agcctgacag caccctgttt cagatccatt ggatatctct aaaatttgct     3900

ctgggactta ccctggcact actatcagga tgcccacaca aacctgattg ggcagcccat     3960

cagcagttgt gaacatgaca tggtgaataa acactctctt ccttgtc                   4007


<210> 1332
<211> 5226
<212> DNA
<213> Homo sapiens

<400> 1332
aatttaccta atcccacgtc cctaacggtc ttcggaagcg aagcagtgtc aacagtccct       60

ggtaaacaca agtagtatta caagtcggga gctcttcaag tcttggatga gactgtagag      120

cggtcttgtg cggcaatgtg ctaccttaaa ataaataaat aaataaaccc ctgttatgtc      180

cggagtttgt ttccacccgg agaggaatgg aagagcacca gagagcgctt agctttctgg      240

ttggatgttt tggtgtggga cttgttttgt gaccaacaat atgaaaggct ctgaggtcag      300

cttggagaag aaaaaaaaga ttaagatgcc agtgaagaga cttcgtgagg tagtttctca      360

aaatcatgga gatcatttgg ttttgctgaa agatgagttg ccctgtgttc ctccggcatt      420

gtctgcaaat aaacgtcttc ctgttggaac ggggactagt ttgaatggaa catcacgtgg      480

ttcatcagac ttaacttctg ctagaaattg ttaccagcct ctattagaaa atcccatggt      540

gtcagaaagt gatttttcta aagacgttgc agtgcaagtg ttgcctttgg ataaaataga      600

agagaacaac aagcaaaaag caaatgacat cttcatttct cagtatacaa tgggacagaa      660

agatgctcta agaacagttt taaagcaaaa tgtctcactt tgtctcacag gctggagtga      720

tcacagtggg gtgatcacaa ctcactgcag tctctacctc ctcaggctca tgagatcctc      780

ccacctcagc ctcccgagta gctgggacta cagagctcaa agcatgcctg tttttaagga      840

agtaaaggta catctgttag aagatgcagg catagagaag gatgctgtta ctcaggagac      900

tagaatttca cccagtggaa ttgattcagc tacaaccgtg gctgcagcaa ctgctgctgc      960

cattgcaacc gcagctccgt tgataaaggt gcagagtgat ttggaagcaa aagtcaattc     1020

tgttacagaa ttacttagta aattacagga gactgataaa cacctgcaac gtgttacaga     1080

gcagcaaaca agcattcaga ggaaacaaga gaaattacat tgtcatgatc acgaaaagca     1140

aatgaatgtg tttatggagc agcacataag gcatcttgaa aagttacaac aacaacaaat     1200

agatattcag actcatttta ttagtgctgc actcaagact agtagttttc agcctgttag     1260

tatgccctcc tccagagcag tggaaaagta ttccgtaaaa ccagaacacc ctaatcttgg     1320

tagctgtaat ccatctttat ataacacatt tgcttccaaa caagcacctt taaaagaagt     1380

tgaagatacg agttttgata aacagaaatc tcctttggag acaccagcac ctcgcagatt     1440

tgctcctgta cctgtttcaa gggatgatga actatcaaag agggaaaatc ttttggaaga     1500

aaaagaaaat atggaagtgt cgtgtcacag aggaaatgta agactattgg aacaaatttt     1560

gaataataat gattctttga caagaaaaag tgaatcatca aacaccacct cactaactag     1620

gtcaaaaata ggatggactc ctgagaaaac aaacagattt ccttcctgtg aagagctaga     1680

aacaactaaa gtgactatgc agaagtctga tgatgttctt catgaccttg gccaaaaaga     1740

gaaagaaaca aatagcatgg tccagccaaa agaatctctg agtatgttga agcttccaga     1800

tcttccacag aattctgtta agcttcaaac aaccaataca acaagatctg tattgaaaga     1860

tgctgagaag attttgagag gagtacaaaa caataaaaaa gtacttgaag aaaacctgga     1920

agctattatt cgtgcaaaag atggagctgc catgtattcg cttatcaatg ctttatctac     1980

caacagagag atgtcagaga aaattaggat cagaaagaca gtggatgaat ggattaaaac     2040

tatttctgca gaaattcagg atgaactgtc aagaacagat tatgaacaaa aaagatttga     2100

tcagaagaat cagagaacca agaaaggtca gaatatgact aaagatatta gaaccaacac     2160

acaagataaa actgtcaaca aatctgtaat tccaagaaaa cattctcaaa agcaaataga     2220

agagcatttt agaaatctac ctatgagggg catgcctgct tcaagtttac agaaagagag     2280

aaaggaaggg cttttgaaag caaccacagt aatacaagat gaagattata tgttacaagt     2340

ctatggaaag ccagtttatc agggccatcg aagcactctt aaaaaaggac catatctcag     2400

atttaattct ccatctccta agtccagacc acagagacca aaagtaatag aacgagttaa     2460

aggcactaag gtaaagtcaa taagaacaca gactgacttc tatgcaacaa aacctaagaa     2520

gatggattct aaaatgaaac attctgttcc tgtgttacct catggcgatc agcaatattt     2580

gttcagccca agtagagaaa tgcctacttt ttcaggtaca ttggaaggtc atctgattcc     2640

tatggcaatt cttttaggac aaacccaaag taatagtgat accatgccac ctgctggagt     2700

gattgtcagc aagccacacc ctgtaactgt gactacttct attcctccat catctcgaaa     2760

agtagaaact ggagtaaaga aacctaacat agccattgta gaaatgaagt cagaaaaaaa     2820

ggatcctcct cagcttactg tgcaggtatt acccagtgta gatattgaca gcatttcaaa     2880

tagtagtgct gatgtccttt cacctctgtc tagccccaaa gaagcatctc ttcctcctgt     2940

gcaaacttgg ataaagactc cagaaattat gaaggtagat gaagaagagg tgaagtttcc     3000

aggaactaac tttgatgaaa taatcgatgt catacaggaa gaagaaaaat gtgatgaaat     3060

tccagactct gaaccaattc tggagtttaa cagaagtgtt aaagctgatt ctacaaaata     3120

taatggtcct ccatttccgc cagttgcttc tacttttcag cccactgctg atattctgga     3180

taaagtaatt gagagaaaag aaacactgga aaatagctta attcaatggg tagagcaaga     3240

aataatgtca agaattatct ctgggctctt tccagtccag caacagattg cacctagtat     3300

cagtgtttca gtcagtgaga caagtgaacc actgacttct gacattgtgg aaggaacaag     3360

cagtggcgcc ctccagcttt ttgttgatgc tggtgttcct gtgaactcaa atgtgattaa     3420

acattttgtt aacgaagctc ttgctgagac cattgctgtc atgctgggtg acagagaagc     3480

aaagaagcaa ggtcctgttg ctacaggtgt ttctggggat gcttcaacaa atgaaacata     3540

tttgccggca agagtgtgca ccccactgcc taccccacag cctacgcctc cttgctcacc     3600

ttcatcacct gctaaggagt gtgttttggt aaagactcca gattcttctc cctgtgattc     3660

ggatcatgat atggcttttc ctgtgaaaga aatatgtgct gaaaaaggag atgatatgcc     3720

tgccatcatg cttgttaata ctccaacagt tacccctact actacacctc ctccagcggc     3780

ggcagttttt accccaactt tgtcagatat ttccattgat aaattgaagg tatcaagccc     3840

agagcttccc aagccatggg gtgatggaga cctgccactg gaagaagaga accctaactc     3900

acctcaagaa gaacttcatc caagagctat tgtaatgtct gtggctaagg atgaagaacc     3960

agagagtatg gatttccctg ctcagcctcc acctccagag ccagttccct ttatgccatt     4020

tcctgccggc accaaggccc cttccccctc acagatgcca ggttctgatt catcaacact     4080

ggagagcaca ttgagtgtta ctgtcactga aactgaaact ttagataaac ccatctctga     4140

aggagagatt ttatttagct gtggtcaaaa attggccccc aagattttag aagatatagg     4200

actgtacctg acaaacctta atgatagctt atccagcact ctgcatgatg ccgttgaaat     4260

ggaggatgat cctcctagtg aagggcaagt gattaggatg tcccataaaa aatttcatgc     4320

agatgcaatt ctttcttttg ctaaacaaaa ccaggagtca gcagtttccc agcaagcagt     4380

ctatcattca gaggacttgg aaaacagtgt gggtgaactt agtgaaggac aaagacccca     4440

gctaacagcg gcagcagaga acatcttaat gggacattct ctctatatgc agccacctgt     4500

cactaataca cagtctttgg atcaacaatg tgatcctaaa ccattatctc ggcaatttga     4560

cacagtttca ggtagtattt atgaagattc atgtgctagt catggtccaa tgagtttggg     4620

agaattggag ttggagccaa attctaagct ggttcttccc acaacacttc tgacagcaca     4680

agaaaatgat gttaatttac cagtagccgc tgaagatttt tcccagtacc aactaaagca     4740

aaatcaggat gttaagcaag ttgaacacaa accatcacaa agttacctac gtgttagaaa     4800

taaatctgat attgcacctt cacagcaaca agtttcacca ggtgatatgg atcggacaca     4860

aattgagctt aatccgtacc tcacatgtgt attttcaggt ttgggggtac atgtgaagaa     4920

ggtttcctgt ataggtaaac tcgggctgtg gaggtttgtc atacagatta tttcatcacc     4980

caggtgggaa agcagtgcca ctctccgctt cacagatgcc ccctgccaag atgtcagtga     5040

tgctgccgtc agtgaacctc gaggactgct ctcagtctct gagtctcagc acaatgcagg     5100

aggacatgga gtcttcgggg gcagatacct tctgaacggg aagagacagc cagcacagtg     5160

tttatgccac tggttttaaa gtcattttac cttggcttaa aaccctctct cagactgttt     5220

ggtttt                                                                5226


<210> 1333
<211> 4596
<212> DNA
<213> Homo sapiens

<400> 1333
atataggaat ggtgcttctc ctgagacaga ggttttgttt agttttttca tctgatactg       60

gatatgtcaa gatgaatcta tgaacttcaa gcaaaactta ttgaagcttt ggtatatgtg      120

agtaatttgt tttagagaac tggagcctat agcgatataa aaaaatagca aatgcaaaca      180

ttttatatga atctactagc atggaaattc tcccatgctt accgtccaag tgaagacttc      240

ctctgccata gaacttccag attccttggc attcctgtgg atcatcccaa tgtggtactg      300

tgaaggcaag gagcttgaaa attccccaga tattcacatc gtccaggcag gaaatctgca      360

ctcactgacc attgcggaag cctttgaaga ggacacagga cgctattcct gctttgcttc      420

taacatctat gggacagatt cgacttctgc tgagatttat atagaagggg tttcttcttc      480

tgactcagaa ggcgacccta acaaggaaga gatgaatcga atccagaagc caaatgaggt      540

gtcatctcct cccactacct ctgcagtcat tcctccagca gtaccccaag cccagcattt      600

ggtggcccaa cctcgtgtgg caaccatcca gcagtgtcag agccccacca attacttgca      660

gggattggat ggaaaaccta tcattgcagc tcctgtgttt acaaagatgc tacaaaattt      720

gtcagcttct gagggtcagc tggttgtctt tgaatgcaga gtaaaaggag ctccatctcc      780

taaggttgag tggtatagag aagggacttt aatagaagat tctccagatt ttaggatttt      840

acagaaaaaa cctcgatcca tggcagagcc agaggagatt tgcaccttgg tcattgctga      900

ggtgtttgca gaagattctg ggtgcttcac atgtactgca agcaacaaat acggcacagt      960

gtcaagcatt gcacagctgc acgtgagagg aaatgaggac ctcagcaaca acgggtctct     1020

tcactcagcc aactctacca ccaacctggc agctattgag ccacagccct ccccacccca     1080

ctcagagcct ccatctgtgg aacaaccccc caaacccaaa ctcgaggggg ttctggtgaa     1140

ccacaatgag ccccggtcca gctccaggat tgggcttcgt gtgcacttca acctgcctga     1200

agatgacaaa ggaagtgaag catcctccga ggctggtgtg gtgaccacca gacagaccag     1260

gcccgattct ttccaggaga ggttcaacgg acaggcaaca aaaaccccag agccttcttc     1320

ccccgtgaaa gagccccctc cagttctggc caaacccaaa cttgattcca ctcagttaca     1380

acagcttcat aaccaagtct tactggaaca acaccaattg caaaacccac ctccttcatc     1440

tcctaaggag tttcctttca gcatgactgt tttgaactcc aatgctcccc cagcggtgac     1500

aacatccagt aagcaggtga aggctccttc atcacagacg ttcagcttgg cccggccgaa     1560

gtatttcttc ccctccacga acaccaccgc agcaactgtg gccccttcca gctctccggt     1620

gttcactttg agcagcactc ctcaaactat tcagaggaca gtgagcaaag aaagcctctt     1680

agtgtctcac ccctctgtgc aaaccaaatc tccaggaggg ctttccatcc aaaatgagcc     1740

actcccacca ggcccaacag aaccaacacc accaccattc acattttcca tccccagcgg     1800

aaaccagttt cagccccgct gtgtgtcccc aattcctgtc tctcctacca gccggattca     1860

gaacccagtg gctttcctca gctctgttct gccttctctc cctgccatcc cacccacaaa     1920

tgccatgggg ctgcctagaa gtgcaccatc catgccatcc cagggattag cgaagaaaaa     1980

tacaaagtct cctcaaccag tgaatgatga taacattcgt gaaactaaga acgcagtgat     2040

tcgagacttg gggaaaaaaa taactttcag tgatgtcaga ccaaaccagc aggagtacaa     2100

aatttcaagc tttgagcaga ggctgatgaa tgaaatagag tttcgcttgg aacgtactcc     2160

tgttgatgaa tcagatgatg aaattcaaca tgatgagatc cccacgggca agtgtattgc     2220

tcccatcttt gacaagagac tcaagcactt ccgggtcaca gaaggctctc cagttacatt     2280

cacctgcaaa attgttggga tacctgttcc aaaggtttac tggttcaaag atgggaagca     2340

gatttctaag agaaatgagc actgcaaaat gaggcgagaa ggagatggga catgctctct     2400

gcacattgaa tccactacca gtgatgacga tggcaactac accatcatgg cagccaaccc     2460

ccaggggaga atcagctgtt ctggccactt gatggtacaa agtttgccca ttcgcagtcg     2520

gctaacctct gctggtcagt ctcacagggg aagatcccga gtgcaagaaa gagacaaaga     2580

gcccctacag gaacgctttt tccgaccaca tttcctgcag gctcctgggg atatggtagc     2640

tcatgagggg cgcctctgtc ggctggactg taaggtgagt ggtttaccgc ccccggagct     2700

gacatggcta ctcaatggcc aacctgtgct accagatgcc tcccacaaga tgctggtcag     2760

ggagaccgga gtccactctc tgctcattga cccactcact cagcgcgacg cagggaccta     2820

taagtgcatc gctaccaaca aaaccgggca gaattctttt agtctggagc tctctgtagt     2880

agccaaagag gtgaagaaag cacctgtgat cctggagaaa ctacagaact gcggtgttcc     2940

cgaaggccac cccgtgagac tggagtgccg cgtgataggc atgcccccac ctgtgttcta     3000

ctggaagaaa gacaatgaga ccatcccttg caccagagag aggatcagta tgcaccagga     3060

cacaacaggg tatgcctgcc ttctcattca gccagccaag aaatcagacg ctggatggta     3120

cacgttgtca gccaagaatg aagccggcat cgtgtcgtgc actgccaggc tggatatata     3180

cgctcagtgg caccatcaga tcccaccgcc catgtctgtc cggcccagtg gcagtcgcta     3240

cggatctctc accagtaaag gacttgacat attttctgcc ttttcctcca tggaaagcac     3300

gatggtgtat tcatgctctt ctcggagtgt agtggagagt gatgaacttt aagaatgtct     3360

aggtacctgc tgtgtaagag agcggactgt ggagggggaa tgagaacaag ccagacttgg     3420

tggtttccaa gcaaccgaag ttgagtaagt tcccacactg ctggacctgt ggcaaagagt     3480

gctttgaata agtcagctag ggattcttgc agtctcagct gagggagaaa ggtagggctg     3540

tgccttctaa agattccaac agagatgtga gaagataata cagatgaacc aaagatgtca     3600

cacagttgcc atccactgct ttgggaaaaa actagcatgc tcccctgctc cctgttgtgt     3660

tagggatgtt taggtcatac taggagcaat taggagccat atgcctgggc tgagaagagc     3720

taggcagtag tgaccttagg atatgactaa ctcaccaaac aatgccaagg agaaaggcgg     3780

acaggtcacc atcacctttc atcgattaca tgtatagcag tagttttggt gaattcacca     3840

aatcagcttc cacttagcat taggaggtca tgccatacaa ctcacgtatg cgggcaaaca     3900

cttttgattt gcatatcctg ggtgtactga gccacataat aaggtgtcaa aatgtgcttg     3960

agattccaaa aacttgctga aacacttgat attgcacagt gcacttattt tgtggccaaa     4020

gcatggcctt accagcttgt ctgcactatt ttcttttggg tggtgactgt ttttttctga     4080

ctttgcatat ccctagacac tagaactaaa ggattggtaa taaaccaatc agaaagaaat     4140

cctctgtggg gtcactttaa aaactactag cttcaactac cacttacaaa atgtgcaaga     4200

gtcatcattt gcccataaaa tacacctcat gggctcctac ccctttcccc aaaagtctga     4260

aagtgtagga ggaaggaaga gatacaaaca aggagaggaa atgatgggag agtgttgttt     4320

ttgtcacttg ccccagcaga gcaggggttt tggaaggaga ggtctttaat agctttgaaa     4380

tgctttgaga tcattggtca aattgcattt tctatgtaga gaatattctg ctaggtggaa     4440

aagttgggag aaaggggaat atgcatcttt attctaatca ccaattcaaa ccctgcctct     4500

taaggaattt ttagacttaa gttcactgtg atatccctag tacctagaag agtacctagc     4560

acaaagtaga cattcaataa atatttgctg gttgaa                               4596


<210> 1334
<211> 1304
<212> DNA
<213> Homo sapiens

<400> 1334
actaagttcc tcctgcgcgg tctatggcgg actatgttag gtcttaatgg tgggaggacg       60

cccgagtgct cggcccgttt caccccgagg aggaaggaca ctgggtcatg acgccatcag      120

agggcgccag agcagggacc ggacgcgagt tggagatgtt ggactcgctg ttggccttgg      180

gcggcctggt gctgcttcgg gattccgtgg agtgggaggg gcgcagtctc ttgaaggcgc      240

ttgtcaagaa atctgcactg tgtggggagc aagtgcatat cctgggctgt gaagtgagcg      300

aggaagagtt tcgtgaaggt tttgactctg atatcaacaa tcggctggtt taccatgact      360

tcttcagaga ccctctcaac tggtcaaaaa ctgaggaggc ctttcctggg gggccgctgg      420

gagccttgag agccatgtgc aagaggacag atcctgttcc tgtcaccatt gctctcgatt      480

cactcagctg gctgctactt cgccttccct gcaccacact ctgccaggtc ctgcatgctg      540

tgagccatca ggactcttgt cctggtgaca gctcctcagt ggggaaagtg agtgtgctgg      600

gcttgctaca tgaagagctt catggaccag gccctgtggg agctctcagc agccttgctc      660

agactgaggt gaccctgggc ggtaccatgg gccaggcctc ggcccacatc ctgtgtcgga      720

ggccccgaca gcgcccaact gaccagactc agtggttctc catccttccg gacttcagcc      780

tggatctcca agaggggccc tctgtagagt cccagcccta ctccgatcct catatacccc      840

cggtggatcc cacaactcat ttgaccttta accttcacct gtccaagaaa gagagagaag      900

ccagagatag cctgatcctg cccttccagt tcagttctga aaaacagcag gctctcctgc      960

ggcctaggcc agggcaggct accagccaca tcttctatga gccagatgct tatgatgacc     1020

tggaccaaga agacccagat gacgacctgg atatttgact ggccagattt gattagattg     1080

taattggagg gggcgcggga agactttggg cccagaacca tctttctatt gtttgtgtta     1140

gccttaccct gtccctgccc caccttggtt ccccttgtct atggagcccc gccttgtgag     1200

ccaggaagca gcgtctcatc aggacagaag gtaggatgaa gacatggggt aatgtgagag     1260

agtagaacac ccccgtacct aataaaaatc tttatttttt tatt                      1304


<210> 1335
<211> 7121
<212> DNA
<213> Homo sapiens

<400> 1335
aaaagggcgg tggggcgggg ggcggggcag ggagagggag agaaatccag cagacatcta       60

gctctgcctt tctttcccag ccacagccag ggtagggctg ataaggcgct gatgcgttga      120

tggcagcctt gcagagctag acctgcactt aacttgcagc tgcctcccga gcctccaaga      180

tgtccacgcc ctgggtgaca ggcggcaggg cgctgccccg tgctcccccg gctctgctcg      240

acagcagcac gcagtgagag cctcgccgcc gccgaggagc aactcatgta acggcacagc      300

caacaagatg aacggagctt tggatcactc agaccaacca gacccagatg ccattaagat      360

gtttgtcgga cagatccccc ggtcatggtc ggaaaaggag ctgaaagaac tttttgagcc      420

ttacggagcc gtctaccaga tcaacgtcct ccgggaccgg agtcagaacc ctccgcagag      480

taaaggttgt tgtttcgtaa cattttatac aagaaaagct gcacttgagg cccagaatgc      540

actgcacaat attaaaactt tacctgggat gcatcatccc attcagatga aacctgcaga      600

tagtgaaaag tccaacgctg tggaagacag aaaattgttc ataggaatgg tatcgaagaa      660

atgtaatgag aacgacatca gggtgatgtt ctctccattt ggccagatag aagaatgccg      720

gatcctccgg ggacctgatg ggctgagtcg aggctgtgcg tttgtcacat tttctacaag      780

ggcaatggca cagaatgcaa tcaaagccat gcatcagtct cagaccatgg agggctgctc      840

ttcacctatc gtggtgaagt ttgctgacac tcagaaggac aaagagcaaa ggcgcctcca      900

gcagcagctc gctcagcaga tgcagcagct caacactgcc acctggggga acctgacagg      960

gctgggcgga ctgaccccac agtatctggc gctcctgcag caggccacct cctccagcaa     1020

cctgggtgcg ttcagcggca ttcaacaaat ggcaggcatg aatgctttac agttgcagaa     1080

cctggcgacg ctggctgctg ctgcagctgc ggcccagacc tcagccacca gcaccaatgc     1140

aaaccctctc tctaccacga gcagcgccct gggagccctc acgagtcccg tggctgcttc     1200

aacccccaac tccactgctg gtgcagccat gaactccttg acctctctcg ggactctgca     1260

aggactggct ggagccactg ttggactgaa taatattaat gcactagcag ttgctcaaat     1320

gctctcaggt atggcggctc tgaatggagg acttggcgcc acaggcttga cgaatggcac     1380

ggctggcacc atggacgccc tcacccaggc ctactcagga attcaacagt acgcagccgc     1440

cgcgctgccc actctgtaca gccagagcct gctgcagcag cagagcgctg caggcagcca     1500

gaaggaaggt ccagaggggg caaacctctt tatttaccac cttccacagg aatttggaga     1560

ccaggacatt ctgcagatgt tcatgccttt tggaaatgtt atctctgcta aagtcttcat     1620

tgacaaacag accaatctga gcaagtgctt tggttttgtt agctacgaca atccagtctc     1680

tgcacaagct gctatccaag ctatgaatgg ctttcagatc ggcatgaaac gcttgaaggt     1740

gcagctgaag cgttccaaaa acgacagcaa accttactga tcctaacccc agaggctccc     1800

tgctctcatt ttagctttct tagggtaagt cccacgagcc agcctgtctc aacagggaag     1860

gcagaggagg accacattgc caacttttac caagagagac ggttattttt acaataaggc     1920

ctccatgtcc ccacccactt cccctaccca gtttgccata attaaaactt gggctacttt     1980

gtttctattg agtaattcct cctccagttg tgccactgta ttctcctttg ttttgcgatt     2040

tgaatctcct tttacctttt tttttaattt ttttcatttt tgcttttttt taaagagaag     2100

catatacaca aataaatggc atcttgagaa tttaaaaggc aaacaaacaa acgctaatgt     2160

gcaattctaa ctctgaaacc actggtgccc cgagagcact gcctggagaa ttcacccctc     2220

cttgcccggc gcccgccccc ggagggaggg cccggtgctt agaggttaac ttggtggcct     2280

aggagaggga gaagccagga gaagcactta ctccaaccac acgtctttcc actacatcgg     2340

cttgttttac taagtaggat tttattttag ggttcaaaga aacatgacat ttattggtca     2400

aaatattaca ctggttgtct attttgttat tgttttattt tagtttttag aaaggattaa     2460

tgtacaaaaa gatttagaga tctgtttctt aaagctacag ggtttaaaaa ataaaaatga     2520

gtgaaaatac ttgatgtttc ttgaaagata aatttaataa taataaataa atacataaat     2580

acataaataa aaaagaaagc cacaggcctg taaattttat ttgtaaaaaa gcatttctat     2640

ttttatacaa aatttttact gcctcagaaa taatggaagt tatttattgc ctattgttaa     2700

cttattgggt acctaaagag cagttctctg tctagctaga accttctgaa gtagtctcta     2760

gaggaattgt tctaggaatg ggcttttttt caccgttgaa ccctagacct gaagttcatg     2820

ctttatcctc tcgttgtttg tatctgtctg attattttgt ttgtaacttc cattatctag     2880

tttacagttc agtcgtctga ctttccccgt atgtcacatt tgttgaaact ggaccttctc     2940

cccctgtccc tcaccccaaa acacccggaa tccatcccgt ttcgctctct ccagatggat     3000

tctcttgggg tttcattgtg ctgtggataa ggagtgtaag aaatgcaaat tatgtgaatg     3060

gctcggagac tccctaatga cctaagattt gcattagttt ttctcctgca cccttaaaag     3120

tgattttgtt gccgctgcat agattctgtg taacttttta ctcttccttg ttttttccct     3180

agacatcttc atgcccgtta gttcatcgtt tgcctagcat gtccctgtgg cgtctcaaaa     3240

aaaagtttca tcgtcccgtc attgtttctg atgtctttct gacctcacat catatttggt     3300

tctcctactg acctttgatc tagtttgacc tttgaaattt gcatgtgacc tcatctagct     3360

atgaattctg ggaagtcaat gtgaaaaaca ttgctgcatt catgcaagac tgaaatttat     3420

tattagacaa attcattata gaaaaaacct gtggcaaaaa cgtttctttc ttattttttt     3480

tcttttccta aaacagactt gaaagtatta tacagggatt ggcattcttc ccggtcactg     3540

gtaacaatag caatatgtgt ccagggacac agaatgttgg tttctaacag actacttcca     3600

aaaacagttt gagaaaaaaa ctgtctgatt ttaagtctct agaggtctgt aatagttttt     3660

acatttttca ggcagtgtaa agttttttga taaggccatt ttaggtggct cactttctca     3720

ttaagatata tatatagaac cactttttgt agattagtat aagaaaaata tttaccctgt     3780

tttggggcaa atgctaccta tttgtgtcac cttttgctga actcacagtt agacaatcca     3840

tggtttaatg cacatgaaat tacctatatt ttatactgtt tcaatgtaca ggagaaaggt     3900

tactgtaaac tgtgttatgt tggtgcttct gtgaattaag ttgtggtttc atcatgagtc     3960

ttaatgttct ttgttgataa gacaagttta gaattggttt acttaataca aaaaaaaaaa     4020

aaagaatttc aaaaaaaaaa gttgtttgct taaaaaaaat ttcatgtgag ggaaaaaaaa     4080

aaaacctatt ccagaataag ttttgtgttg gcttgtgaag cattgatgtc atttttttta     4140

attgtggact atttagatgt gtttgtgttc agcaaaatgt gatgtttttt tcttttaaag     4200

aaaaaaagtg aaaatatata gtgccaaatt ccaaaggtac ttccttccta gagcttcagt     4260

gtgtttcttg tgagaagtaa tttgataaca tgggtatttt attatgtgtt ttgtataaat     4320

ccctaatatt taaaaaaaaa aacaaaacaa aaaaaggtta caaagtttgt taacttgcta     4380

tcctgtggtc ttgttgcctg aaattgttat tgtttgttat ttctctctga tgttttttgt     4440

aagacattgt ataagtgccc atgtcccact tttttaacca ctccgcacat cagtgctgtg     4500

aaggcaacct caccatgtat tttcttcata atctatggaa acctctaagg tgagaaagtt     4560

ttgaactttt aaccctttct acccagagct atctggaatg ttgatgactt tttatactgt     4620

catgatttga gtttgttttg gggtgtttcc aatttggatt tttttccctg catctatcct     4680

ctaagttgtt tcggtttgac tactttgttc tttggttaag atccaaaaga aaacagaaaa     4740

caattccacg aggccaatct aaagggaaaa aatcctacac tacttttact acttttgatt     4800

atttctcatt tttgggaaaa gaattcctaa tgtgctacta gaattccttc ttcagtttta     4860

acgagtaatt ggataaaccc tgagggaaaa cggaggtaga ttcagcacct aacaatcctg     4920

tatgcttttg agatcacgtt tagtgctatg tcctagtcta gaatattttc atataccttg     4980

cagtaaaacg actttgtggc aggacagtct cttgaggggt tttgtttctg tttcctaaat     5040

actcctaaat aatatttcta atcagccatt atgctggggc atctctgatc ccagtaggta     5100

cctctgaata taccaggtgt ctggagttag aagcccatag ccctttccca gcctttttgg     5160

tttttttaat tgaacacatt tcatctaagt aaagctcagt tctttatcac aatttactga     5220

ccaaatacct agcaccagtt cctgctgcca ctttttaaag tgccatatga ctttctacga     5280

acaggtacct tgctgtcttg acaaatccta atgtcacgcc tacagcccca acacaagctc     5340

cagtcttcct cttcggcatg ccctggaagc ttcttccagt cttcctcttc ggcatgccct     5400

ggaagcttct tggcctcagc tccccttccc cgctcagcac cctgttagga tcagtgtgtg     5460

tggatgggat agccctggga tggaaaggac tagcctctac tgatgcaaaa aaacaaaaag     5520

caacacaaac gtttccttct tatagcacat gcacttcctt acaatgacat gatttgtatt     5580

atcctcacat gtgtttacta ctgctggggc cttccttcat cctctgaggg ctattttgta     5640

ctttctgcag caatcagctt aataacaaca cttattgcac ctgtctctct ctgagaacac     5700

ggtgtgtctc gacacgtacc acgtacgtgg aaacacaaga gcccaccact tgaatttcta     5760

agaccatttc attctgaaac ttcttatcaa ttacctaaat ctcaacgaaa aacaatttac     5820

tgaagccgac tcccctcccc atctccctct caacctcaac ccacctgcat gcatctcccc     5880

cagaggaaac actgagggta ggggacagga ggctcaggac gcgccctctg aatcgagtgt     5940

ttcttcttca caagtcacca agagaggaca tgagggggaa agtccttttt gcccttctcc     6000

aaaaaataac cttccacaga gacaaactgt ccttctatcc acttttatct tttaataaat     6060

atcaaaagga aaaagctgca agggtgcaaa gggcctgtgc cagaagaaaa cacacacagg     6120

gaaaccgctt tttttaatca attgtagaga atagtcattt ttaatctaaa ttagagaatt     6180

gtgatacaat ggcagtcctc aaaggcgtaa cgagttcatc tttctttcac cataggggtt     6240

atagttggct tgtgctactc tggaatcatt ttactgtttg tttttattat cttaagtgct     6300

aattaaaaaa aaaataaaat tttaaaaaaa cctgtagttt cattaccttt ttgaataatg     6360

tcatacaaaa aatgtatttg tttttttgtg ctgtgagaat tgatgtttgt agattaataa     6420

tcattttgtt tagaattaca aaatagtttt taaatattgt ctgagaaaag ccaaagttaa     6480

tgcaacctag tggaaactgt aagaccattt gagtattgtt tgttttattg atgcatttgg     6540

attttgttgt ttgatggaat ttgagccaaa aaaaaaatac gcaggctttc ctatttctac     6600

aactgattgt acttatgcat tttgtaccag tggaactttt tatactggag attaaaaaaa     6660

aaatggaaat ttttgtggct tgctctggtg ggcccctgac aatgactgat ttcaagtttg     6720

atttcgggtt gattgattga ttgattgata gaaagaaagt tgcttttctt ttgagaatta     6780

aaaactttgg cttgatttct tttttccctt tgcttatatc tagcattaga attttgtctt     6840

aaaataacag cggtaagttt cactttttat tctgtattgt gcagttacac aataaggtaa     6900

ttagatttag aagtactcag tcactttaag tggataaatg tattagttaa aactttaggg     6960

tttgcttttt tgctgtttag atcaaagttt tttctgattc ttctgtcctc attgtgaaca     7020

taaccgtgta gttgaaacag tcaaacttat ttttgtaatg tatgttattg tgtgatgcag     7080

ttttttgctt ctgtctccaa tattaaacca ttttcctaat a                         7121


<210> 1336
<211> 1835
<212> DNA
<213> Homo sapiens

<400> 1336
acgcaagtcc ctttcctccc gacacgagtg cagtaaagaa aaacggttat gagcgtaaag       60

tgacagcctc ggccgatggg aataggggga agtccgacac tgagcaacga acgcattccc      120

gcgcctccaa aacctaggcc gggggcgctg gaaaccctta ccggcacccg gccaccgcgg      180

cagacgcttg ctcctgccac gccccccccc cctcccccgc atcacgtgtc tgcactcgct      240

ttcctcggat tcccggatgt ggttgccaaa acaaagggga tttggtgatg gaggctttgt      300

tagaaggaat acaaaatcga gggcatggtg ggggattttt gacatcttgt gaagcagaac      360

tacaggagct catgaaacag attgacataa tggtggctca taaaaaatct gaatgggaag      420

gacgtacaca tgctctagaa acttgcttga aaatccgtga acaggaactt aagagtctta      480

ggagtcagtt ggatgtgaca cataaggagg ttggaatgtt gcatcagcag gtagaagaac      540

atgaaaaaat caagcaagag atgaccatgg aatataagca ggagttgaag aaactacatg      600

aagaattatg catactgaag agaagctatg aaaagcttca gaaaaagcaa atgagggaat      660

tcagaggaaa taccaaaaat cacagggaag atcggtctga aattgagagg ttaactgcaa      720

aaatagagga attccgtcag aaatcgctgg actgggagaa gcaacgcttg atttatcagc      780

aacaggtatc ttcactggag gcacaaagga aggctctggc tgaacaatca gagataattc      840

aggctcagct tgtcaatcgg aaacagaaat tagagtctgt ggaactttct agccaatcag      900

aaattcaaca cttaagcagt aaactggagc gggctaatga cactatctgt gccaatgagt      960

tggaaataga gcgcctcacc atgagggtca atgacttggt tggaaccagt atgactgtcc     1020

tacaggagca gcagcaaaaa gaagaaaaat tgagggaatc tgaaaaacta ttagaggctc     1080

tgcaggaaga aaagagagaa ttgaaggcag ctcttcagtc tcaagaaaat ctcatacatg     1140

aggccagaat acaaaaggag aagttacaag aaaaagtaaa ggcaactaac actcaacatg     1200

ctgtagaagc tataagtttg gaatctgtga gtgcaacgtg taaacagctg agccaagaac     1260

taatggaaaa atatgaagaa ctgaagagga tggaagcaca taacaatgaa tacaaagcag     1320

agattaagaa gttgaaagaa cagattttac agggtgaaca aagttacagt tctgcactag     1380

aaggaatgaa gatggaaatc tcccatctaa ctcaggagtt acatcagcga gatatcacta     1440

ttgcttccac caaaggttct tcctcagaca tggaaaagcg actcagagca gagatgcaaa     1500

aggcagaaga caaagcagta gagcataagg agattttgga tcagctggag tcactcaaat     1560

tagaaaatcg tcatctttct gaaatggtga tgaaattgga attgggttta catgagagat     1620

ggggttttac catgttgtcc agtctggttt tgaacttcgg gattcaagca atccgccagc     1680

ctcagcgtcc caaagtgctg gaattacaag tgtgagctac caccactggc agttaagaat     1740

tttaacaatt tgtcaatgaa acaagaatct caattagagt ctttatatac aatctgtact     1800

gttggaattt tcaaataaat attgtaaaga aaatt                                1835


<210> 1337
<211> 8076
<212> DNA
<213> Homo sapiens

<400> 1337
atgaggatag aagagaggaa atcccaacat ttaacaggtt tgacagatga aaaagtgaag       60

gcatatcttt ctcttcaccc ccaggtatta gatgaatttg tatctgaaag tgttagtgca      120

gagacagtag agaaatggct gaagaggaag aacaacaaat cagaagatga atcagctcct      180

aaggaagtca gcaggtacca agatacgaat atgcagggag ttgtatatga actaaacagc      240

tatatagaac aacggttgga cacaggagga gacaaccagc tactcctcta tgaactgagc      300

agcatcatta aaatagccac aaaagccgat ggatttgcac tgtatttcct tggagagtgc      360

aataatagcc tgtgtatatt cacgccacct gggataaagg aaggaaaacc ccgcctcatc      420

cctgctgggc ccatcactca gggcaccacc gtctctgctt atgtggccaa gtccaggaaa      480

acactgctag tagaagacat ccttggagat gaacgatttc caagaggtac tggactggaa      540

tcagggactc gtatccagtc tgttctttgc ttaccaattg tcactgcaat tggtgacttg      600

attggtattc tcgagctgta tcggcactgg ggcaaagaag ccttctgtct tagtcaccag      660

gaggttgcaa cagcaaatct tgcctgggct tcagtagcaa tacatcaggt gcaggtatgc      720

agaggccttg ccaaacagac agaattgaat gacttcctac tcgacgtatc aaaaacatat      780

tttgataaca tagttgcaat agattctcta cttgaacaca taatgatata tgcaaaaaac      840

ctggtgaatg ccgatcgttg tgcgcttttc caggtggacc ataagaacaa ggagttatat      900

tcagaccttt ttgatattgg agaggaaaag gaaggaaaac ctgtcttcaa gaagaccaaa      960

gagataagat tttcaattga gaaaggaatt gctggccaag tagcaagaac aggggaagtc     1020

ctgaacattc cagatgccta tgcagaccca cgctttaaca gagaagtaga cttgtacaca     1080

ggctacacca cgcggaacat cctgtgcatg cccatcgtca gccgaggcag cgtgataggt     1140

gtggtgcaga tggtcaacaa aatcagtggc agtgccttct ctaaaacaga tgaaaacaac     1200

ttcaaaatgt ttgccgtctt ttgtgcttta gccttacact gtgctaatat gtatcataga     1260

attcgccact cagagtgcat ttaccgggta acgatggaaa agctgtccta ccatagcatt     1320

tgtacttcag aagagtggca aggtctcatg caattcaccc ttcccgtgcg tctctgcaaa     1380

gaaattgaat tattccactt tgacattggt ccttttgaaa acatgtggcc tggaattttt     1440

gtctacatgg ttcatcggtc ctgtgggaca tcctgctttg agcttgaaaa gttgtgtcgt     1500

tttattatgt ctgtgaagaa gaactatcgg cgggttcctt atcacaactg gaagcatgcg     1560

gtcactgtag cacactgcat gtatgccata cttcagaaca atcacacgct tttcacagac     1620

cttgagcgca aaggactgct gattgcgtgt ctgtgtcatg acctggacca caggggcttc     1680

agtaacagct acctgcagaa gttcgaccac cctctggccg ctctctactc cacttccacc     1740

atggagcagc accacttctc ccagactgtg tccatcctcc agttggaagg gcacaatatc     1800

ttctccactc tgagctccag tgaatatgag caggtgcttg agatcatccg caaagccatc     1860

attgccacag accttgcttt atactttgga aacaggaagc agttggaaga gatgtaccag     1920

accggatcac taaaccttaa taatcaatca catagagacc gtgtaattgg tttgatgatg     1980

actgcctgtg acctttgttc tgtgacaaaa ctgtggcccg ttacaaaatt gacggcaaat     2040

gatatatatg cagaattctg ggctgagggt gatgaaatga agaaattggg aatacagcct     2100

attcctatga tggacagaga caagaaggat gaagtccccc aaggccagct tgggttctac     2160

aatgccgtgg ccattccctg ctatacaacc cttacccaga tcctccctcc cacggagcct     2220

cttctgaaag catgcaggga taatctcagt cagtgggaga aggtgattcg aggggaggag     2280

actgcaacct ggatttcatc cccatccgtg gctcagaagg cagctgcatc tgaagattga     2340

gcactggtca ccctgacacg ctgtcccacc tacagatcct catcttgctt ctttgacatt     2400

cttttccttt ttttgggggg ggtgggggga acctgcacct ggtaactggg gtgcaaacct     2460

cttcaagaag gtaacatcaa ataaataagt caagcagagg acttcctgcc aatctcttct     2520

gtgaggcatc atagacactg agcaaccagg accaccccca cgttcagaaa tcagctggcc     2580

aagtgactcc atttgacttg caaaccagcc ttttctaata ggctaatatt gctgaggcct     2640

taaaggaaat ggacaaaaat tatccagaag gggtactttt ccattgtatc tttctaataa     2700

gggtttaaaa tggtactatt atggtattgt acttgggctt taacatcaat gttgctttga     2760

tgttgttgga tataaatagg aatttttaca cattactatt gtgaatggtg aatgttcatg     2820

tatgacctac ttgtaattaa cttgagttgt agtccacagc ctcaggacaa atgtcgttga     2880

ggttacagag taagaaatga tggcaaaacg tcaaactctt atttcagagc ttcatgaatt     2940

tagttagact aaacataatt ctttaagttc aacctaaagg gctgagatca ataaatttaa     3000

cactagacga agtagacttc ctgtcttttt gagaagagat gaggtatatg ttacaataaa     3060

tctcagaact tcaagtagca gttcaaaaga tgtcagtttt taaaattgtt tttgttgttg     3120

tcttggcagt tttactgaac cctttgcata aagaacaaaa taaaagctcg gcattgtaat     3180

ttttttaatg gacaagtctt atggatacga agggtacatt tttcataatg attcctttat     3240

attttcactt tgtgtcattg cagaatttta gactctcatt cacaatgaaa agtttatttt     3300

aaacattgtt taattaaaat accatacagt tctcttttaa acatcaaacc ataaaaagtg     3360

tattttgtaa ttttactctg acctgccgca gtcacctctc acttatctct tccacgtact     3420

gcacggtcgt atttcatgag ctttctgtcc atagcacaga aacagagcag aaagtagtac     3480

aatcatgttg gaccttcttt ctgttctctt tactcttctc acagatcaga tcactccata     3540

gaagcctgtg ggtttcgatg gtttcttcta tacacctttt tggttgacca gtattactat     3600

acaatgtaag tgttttaaaa aatacgaaag taatactctg caccccttcc tacaaagatg     3660

ataaagcagt cacttctggc gcattttaat aatttaaaga tttttagtgc aatggcacgg     3720

taacctccaa acctgaatta gacagagact cactcaggaa gtgacaggcc catcatatca     3780

aataacttat tcacttttca tgtggcagga aactggaata tcgcttttaa taaaatggaa     3840

aaatatgctt ctacatattt accaccatag gcgttttgtt catatgagcc tggtttgtgc     3900

aaaattaaat cagaggcttc tacaacatgg tttatttatg ttgtagcaaa gttggctcta     3960

cataaacatt gttcttattt taaaattaac actatgtgtt cagttttctt gtgggcttct     4020

gaaagttgcc atcttccctc cgtggagctc catttgctat tttcattata cactatgagg     4080

taaaatgtaa taacaaaaga gagagaagta ccactgtggc tagatatata cacacacata     4140

tatatatgga tggatgtaat atatgtagaa cacacacata gatgtatata ggatacacac     4200

tcatgtatgt aaacgtatac atatgtgtat atatgataca tacacataca cacacacgag     4260

agacagaagg aaagagagga agagagaagc aaacatgtag gaaaaaatat aaatcagccc     4320

cattctccca ttctttaaga acaatgattt ttcttgatgg aaaatgcata tcacttgaca     4380

gttgacaaga aagtgtcatt tttgtgttag tgtatcatat aattgaattt gaacaagata     4440

catatttttc tgcatacaaa tttatgaagc tggagtctac caaacacagc tttagtcaca     4500

aaagttagtt tagttatctc atttcgcttg gagatggaat ttcaggaagg gatatattat     4560

ttaagattat tgtttaatta caagaatttt aaaagaatgt atgaattctg ttttttaata     4620

tagaaaataa ttatggagtt aggaatctca tggctacatt tacattttta ggttattaca     4680

gaaaattctc ttaatttatt atagtcaagt gtattatgta atctctattt agaacagttt     4740

cccaaaggaa tgtgattgga tttactggtt ggttaatttc ttgtgaaata ttgtcataat     4800

agaagcacag cttgaacaaa agactgaatt ctgatataaa ctgtcaatat tgcttttacc     4860

atgtgtaaga tttacttagt aatcacagat ttacctaaaa taaaaggacc cgggttgcag     4920

tgatatttag ttaatgattt gttttggaaa acatgcagtt aggagtattt ttgtattttg     4980

tcagatgttt aggagacaga ctttcgggtc atgtttcttg tcttgttccc agatcttttc     5040

ttaaaagaac agtgtgacac cagaagccaa gagatggttt ttactaacaa cagctttgat     5100

gagttcctat taaggtcgta ttgtgtattg tgccaaattt tccacccagt ataaatttag     5160

taacccgcta tgagcatatg taggatattc aatttgcaga tacttttgtt ggttatgttg     5220

gtttataata gacaagtttt atggtcatat gcaattattc cattatcttt ttggacacag     5280

tgaatatgtt ttttagctaa aaatgtcctt ggaaacataa atgcctgcca ataacatgga     5340

atattgaatt cgggcaatgt gaattgatta attagaaaag ggtcaaaaga aatacaatgg     5400

atgtggaaac taattctaaa aaatagccct attaataggg cagagactct ggtccatttc     5460

ccagctgtac ttctctctaa gaggtgtatg aaaaacccat cttgcaaaag agaccaaaat     5520

attagacaca atcgttccca ttcctgactc ttcaatggaa aaggaaggta cagatgttta     5580

cagtggtgcc ccaggtgact cgttctcacc acaacaaaag caactaattg gaaactagat     5640

gtgttcaata atagatttcc tcttttttgg catgcttttt agattttttt tcattttgta     5700

aaatctcagt taatttttct ttattggtat atttgtgtat gcgagacaaa tcctgtattg     5760

tacaggatat aaatagatgc ataaatcctt agatacctgg gttttttaat aggtttaggt     5820

ttgggtattg tgtttctggt cttttaactc aaaattaagg tttgagcttt aataggacta     5880

aattattcac ctgccttggc ctgtgccttt attttaaata ctgcaatttt acttcttcat     5940

tcatgtattt attattttgc ttttcttgct taagtataat tgaaaatatt tgcaggaacg     6000

cacaattcat tttatcaagt tgaatgaata ggaccattct ctcctcatca gatttctgtt     6060

ctttatttga cttcattgac atataccctg gtgactataa ccagtgaact gttcagagtc     6120

agtcttttcg gcaagaactt cagagaactg tgacactggt tatgatgtga ttttgggggg     6180

tttcaggtac ctaagcatga tttttaaaat cacttctctc tttacatatt tcgaacatat     6240

gtttgctttc tacactttgc agattttatt taggatttaa ttctttaaag actatattca     6300

tttagtcact atagtggatc tcttctactg caagtattca tctgattttt aaattatgta     6360

aaatgtaaat cagccaagta tgtcatccgt tatagtttcc ccatgctttc agcgcatggc     6420

catgagattt ttacatgtgc ataagtattt agccaataca cattttgctg acttctttaa     6480

ccatttatat tgtttaaatt agtaatatcc aatgcagtgc acactttttt gtcttttttc     6540

caacggaata ttttggttgt ctgtagcgtt ggaagcattt tatatgataa aaatagcaag     6600

aaaaaattaa aaagtgtcaa cggtgtgctg gttctaaatt aagaagatag aacaaagaga     6660

aagacattaa tgttacctaa gaaacacatt taacatccga agaagcaatg ctgtcctcac     6720

ttgatgtttc tcttctcaac ccagcaatgg agagcagggc ttgcaaagcc gtacagagcc     6780

tacgtgctct ttcctgcaag tgggagaaaa ctaatcaatg gcacacaggg ccaggtgtgg     6840

ccctgtgagg caaaggataa tgtcacctca ggaccaaggt ggaaacttac agctgaatcc     6900

agggcttact aagtagggaa gtcagtttac atatttcagt tttcctctga tgtttttgag     6960

gtactgtgta tttgcagaag tttaagcaga agggttttgt ttctattgta agttaggttc     7020

taaaagtgta taatctgata ctctagccca actgaaatat tatatcttgg gcgttacagc     7080

ctttgtcttt ttctttagtc accttaatac ccagtcctat gctgtatctc tgatagccta     7140

tataaatgac atataggaat attattttcc atatgatctg ttgtatggtg tatatgctat     7200

gtgttcattt cgtgtgcaag ttcagagtgt aatagattta cccagagaag gtgtttctat     7260

acaatgcccc tacctatttg aaattacatg cttgcccaac acactgtgaa atagttacca     7320

aaatttgtac aaatgcagca tcttcattct ttctgagaag acaagatggt tttctttaca     7380

tgaacaaatg aacaaaagag atcctagatc cataacgtag ctaaggcatc taagagtttg     7440

ctgttgataa tcttgctgac caaaaactac tggagagtaa cacaggttat atgccatcac     7500

aaatacaatg ctcatgaaga actgatttgt agagtcaatg aacctgtgtc cagaatttta     7560

ataggctctc tattggaagg agaaagaatt tcaagttaac agtatctaac tttatcatag     7620

ttgatgttag taaattttaa aaaatgattt tatatgtatg acaaaaatct ttgtaaaatg     7680

cgcaagtgca ataatttaaa gaggtcttaa ctttgcattt ataaattata aatattgtac     7740

atgtgtgtaa ttttttcatg tattcatttg cagtctttgt atttaaaaaa catttactgt     7800

tatgtttgta taatagaaca gtaatcattt attataatct aggcaagttg taaataaatt     7860

cataattcaa acagccagta tatatgcata tatgagtgtt atattgcaaa atctttgttt     7920

tacttacatg gttaaagcag caagaattct tttgttgata tgtaattata cacataaaat     7980

atatatatgt atgatacatg aaatatattt agaaatgttc ataattttaa tggatatcct     8040

ttggtgtgaa taattgaata cagagttttt aaaata                               8076


<210> 1338
<211> 4959
<212> DNA
<213> Homo sapiens

<400> 1338
ggaagttgag cggcggcaag aaataatggc ggcagctacg ggggatcctg gactctctaa       60

actgcagttt gcccctttta gtagtgcctt ggatgttggg ttttggcatg agttgaccca      120

gaagaagctg aacgagtatc ggctggatga agctcccaag gacattaagg gttattacta      180

caatggtgac tctgctgggc tgccagctcg cttaacattg gagttcagtg cttttgacat      240

gagtgctccc accccagccc gttgctgccc agctattgga acactgtata acaccaacac      300

actcgagtct ttcaagactg cagataagaa gctccttttg gaacaagcag caaatgagat      360

atgggaatcc ataaaatcag gcactgctct tgaaaaccct gtactcctca acaagttcct      420

cctcttgaca tttgcagatc taaagaagta ccacttctac tattggtttt gctatcctgc      480

cctctgtctt ccagagagtt tacctctcat tcaggggcca gtgggtttgg atcaaaggtt      540

ttcactaaaa cagattgaag cactagagtg tgcatatgat aatctttgtc aaacagaagg      600

agtcacagct cttccttact tcttaatcaa gtatgatgag aacatggtgc tggtttcctt      660

gcttaaacac tacagtgatt tcttccaagg tcaaaggacg aagataacaa ttggtgtata      720

tgatccctgt aacttagccc agtaccctgg atggcctttg aggaattttt tggtcctagc      780

agcccacaga tggagtagca gtttccagtc tgttgaagtt gtttgcttcc gtgaccgtac      840

catgcagggg gcgagagacg ttgcccacag catcatcttc gaagtgaagc ttccagaaat      900

ggcatttagc ccagattgtc ctaaagcagt tggatgggaa aagaaccaga aaggaggcat      960

gggaccaagg atggtgaacc tcagtgaatg tatggaccct aaaaggttag ctgagtcatc     1020

agtggatcta aatctcaaac tgatgtgttg gagattggtt cctactttag acttggacaa     1080

ggttgtgtct gtcaaatgtc tgctgcttgg agccggcacc ttgggttgca atgtagctag     1140

gacgttgatg ggttggggcg tgagacacat cacatttgtg gacaatgcca agatctccta     1200

ctccaatcct gtgaggcagc ctctctatga gtttgaagat tgcctagggg gtggtaagcc     1260

caaggctctg gcagcagcgg accggctcca gaaaatattc cccggtgtga atgccagagg     1320

attcaacatg agcataccta tgcctgggca tccagtgaac ttctccagtg tcactctgga     1380

gcaagcccgc agagatgtgg agcaactgga gcagctcatc gaaagccatg atgtcgtctt     1440

cctattgatg gacaccaggg agagccggtg gcttcctgcc gtcattgctg caagcaagag     1500

aaagctggtc atcaatgctg ctttgggatt tgacacattt gttgtcatga gacatggtct     1560

gaagaaacca aagcagcaag gagctgggga cttgtgtcca aaccaccctg tggcatctgc     1620

tgacctcctg ggctcatcgc tttttgccaa catccctggt tacaagcttg gctgctactt     1680

ctgcaatgat gtggtggccc caggagattc aaccagagac cggaccttgg accagcagtg     1740

cactgtgagt cgtccaggac tggccgtgat tgcaggagcc ctggccgtgg aattgatggt     1800

atctgttttg cagcatccag aagggggcta tgccattgcc agcagcagtg acgatcggat     1860

gaatgagcct ccaacctctc ttgggcttgt gcctcaccag atccggggat ttctttcacg     1920

gtttgataat gtccttcccg tcagcctggc atttgacaaa tgtacagctt gttcttccaa     1980

agttcttgat caatatgaac gagaaggatt taacttccta gccaaggtgt ttaattcttc     2040

acattccttc ttagaagact tgactggtct tacattgctg catcaagaaa cccaagctgc     2100

tgagatctgg gacatgagcg atgatgagac catctgagat ggccccgctg tggggctgac     2160

ttctccccgg ccgcctgctg aggagctctc catcgccaga gcaggactgc tgaccccagg     2220

cctggtgatt ctgggcccct cctccatacc ccgaggtctg ggattccccc ctctgctgcc     2280

caggagtggc cagtgttcgg cgttgctcgg gattcaagat accaccagtt cagagctaaa     2340

taataacctt ggccttggcc ttgctattga cctgggactt ggtcctccat gcagttttta     2400

tttcttgtca cagtgactga tagccatccc ccaggatcct ttccccttgg ccctgagggg     2460

gtgacccaac acagaccaaa tggggaaatg agcaaccagc tcctgcccag agccactgcg     2520

ggaggtggca ccctcatccc cggaatgtgc tgcccaccgc accgcaggct cctcctgtgg     2580

gggccctggg catgggtgag ggtgggaccc cgtgagcgca ctgcaccctg gccctggtgg     2640

agcgggagga ggaggagagc cgagctgggt acgagactaa agggcccaca tgacccagtg     2700

acgccagatt tccaccaagg actgagtgag ctgctcagac atggctttct gcctcccagc     2760

ctgtcctcca ctgtgggcat agcatctgtg cctgcctgcc tgcttgaggg agaggagttt     2820

ctgctgctgc cttgagctgg ggggaagagc ccaggggcag atcctggcag ctgcctggat     2880

ggggctcctc cctgccctta tgagcaggcc aggcccagaa aggccgagcc tgggctgcct     2940

tcctgcccca gccgagggag gggtcagacg gctctaccat gggtaactca ggcaagagct     3000

ggttttcctc tttattctgg gtgtgtgcag ctgtgaggcc ccaacccagg agaggccatg     3060

gcctaggtac ctgtgaccac cctgcccccg tgtagagggc atcgtctttc ctgctatttt     3120

attctttcag cttttgtctt aggcccagaa tcaaagtgaa aattgagtcg agctgaccct     3180

tacaacagta ggatttagta gggtagattt caaatgaggc ttcgcttctc ccaaagtagc     3240

cagtccaagt tccagtggct gtcgttcagc tcatgggagc ttcatgggga cacagccggc     3300

acaggtgcag ggcccgagtc cgcccaccca gcctggcgct gaaactgcac acgtacacta     3360

tgtggtttaa gagcacttta ttattgttct taaggctact tttaagtaca aaaaaagatg     3420

gcctgccaaa cctttttttt tcttcttcca ggaaaaacag gccacagaga atggtatatt     3480

acagatttac acacatgaag agaaggtcag agcgcactgc aggcagcgcg gctctgggaa     3540

gaacttcacg gagccccttc ttagagcagg gagggggctt tctcagtgaa atgtttggtt     3600

ttctgctgcc tcctctgccc caggcccccc tccagggtac tgcctatccc agataggtca     3660

gtgcaccagg gacccggccg ccagcaccgc cgacccctcc cagagtgacg cccttgttca     3720

ctgacaaaga gacctgtccc aggagtgtcc tccaccgagc cggtcagctg tgggtggttt     3780

tcctgttacg acgctcagta gcctgtagca ataacaaact cgtggctatg aatgcagatg     3840

cagtgttctc atagaataac tgttcctgca cttttacaga caaatctacg acaaaaaaaa     3900

agatcaactt tttttttccg aacaacaaaa aaaatgaatg attacaatag gaaagggaaa     3960

aattaaatag ctacatatca ttaacaaatt aatgttcttc aaaaaatacc tacaaatttc     4020

tctgtacatt ctttacgcac agcgtaacga tggtctcaaa atcacccata tagaaaagtg     4080

ttctcaacga tttttcctac agaaaatata ggggcctgaa tgccaaagct tggaagccca     4140

gtacagtggg agtgaaatgt gtgcggggca aggagaaggg cttttctttc ctccactttt     4200

caaaggcctg cagccactct gtgactacaa gagccagtcc tccgaccttt tcacccagtg     4260

ccaatttcca aaattcaaca gctaaaaact gtaaaaccgg gggtcatacg gtgtgcagag     4320

tccacaaagc cttgcaggtg aggtgaccac gcccacgtca cctggtcagg tgccatcgtc     4380

gtgagcctct ggtgggccag gtgggacaca gcacacccca gggggagggg atagaaacgc     4440

tcattgacca aaaaggagca gctgtgacct ccacagctgt gtctgtcatg cttgcttcat     4500

ctaatttcta gttagtagct attaatatag caaataataa atgcagtaat aacagtataa     4560

agtcagagga atgtatactg ccttggcccc agcgtacgag gaagcgtata aaacaccata     4620

tcacagattg tctgtcagta atctgctgtt cagccaagag agttcaaagg gagcagtttc     4680

tgcatgtagg gaagttggaa gacacaaacc ccacctcccc tgggagcttg taacaaagca     4740

gacagggatg caaaaataaa tgatgtcagc ctgcagccaa actccagcat cccacaccgc     4800

agctgaccca ctgctcatcg cgagggcctg ccaggagctg gcctcccgca ctacttgtga     4860

gtaaagtgaa tatcaaatac caatcttaga gtacaactgt accagcagta agtatatcta     4920

ggactgtaac tgacaaaaat aaactaattc tgaaaagaa                            4959


<210> 1339
<211> 3646
<212> DNA
<213> Homo sapiens

<400> 1339
gctcagccta acggaagtgg aggagccgga cctctttgtg ggaagcgaat tgaatcacct       60

tggcaacccg cggggcgtgc agcaacgccc tttcctccgg aagtgggtgt cagaacctcc      120

acgtgctgtc cctccccctc cccttttcgg cccagtagcg gcggctcagt tgctgccatg      180

gagtcagccg ggctagagca gctcctacgg gagctgctgc taccggacac cgagcgcatc      240

cgtcgggcca cggaacagct ccagatcgtt cttcgggccc ccgccgcttt gccggctctc      300

tgcgacctgc tagcctcggc ggccgacccc cagatccgcc agtttgcggc cgtgctgacc      360

cgcagacgac tgaacacccg ctggcgacgg ctggcggcgg agcaacggga gagcctcaag      420

tccctgatcc tgacggccct gcagagagaa acagagcact gtgtgagcct cagcctggcc      480

cagctctcag ccaccatttt tcgaaaggaa ggcttggagg cctggccaca gcttttgcag      540

ctgcttcagc acagtaccca cagcccccac agcccagaga gagagatggg gcttttgctg      600

ctaagtgtgg tggtgacctc ccggcccgag gccttccaac cccaccaccg ggagcttctt      660

cggcttctga atgagactct tggtgaggtg ggctctcctg ggctgctctt ctactccctg      720

cgcactctga ccaccatggc tccctacctc agcactgaag atgtgcctct cgctcggatg      780

ttggtgccca agctgatcat ggccatgcag actctgatcc ccatagatga ggcaaaggcc      840

tgtgaggccc ttgaggcttt ggatgaactg ttggagtcag aggtgccggt catcaccccc      900

tacctctctg aagtcctcac attctgcctg gaggtagcta gaaatgtggc cctgggcaat      960

gcgatacgca tacgtattct ctgctgcctc actttcttgg tcaaagtcaa gagcaaggcc     1020

ttactgaaga atcgtctcct gccacccttg ctgcacaccc ttttccccat tgtggctgct     1080

gagcccccac caggccagtt ggatcccgag gaccaggatt cagaagagga agagttggag     1140

attgagctga tgggggagac tcccaagcat ttcgctgtac aagttgtgga catgctggca     1200

ctacacctgc cccccgagaa gctctgtccc cagctgatgc ccatgttgga agaggctttg     1260

cggagcgaga gcccatacca gcgcaaagct ggactcctgg tgctggccgt gctgtctgac     1320

ggagctggcg accacatcag gcagagactg ctgcccccac tgctgcagat tgtgtgcaag     1380

ggcctggagg acccctcgca agttgtacgc aatgctgcgc tgtttgccct gggccagttc     1440

tcagaaaacc tacagcccca tatcagcagc tattcaaggg aggtaatgcc actgctcctc     1500

gcctacttga agtcggtgcc tcttggacac acacaccacc tagccaaggc ctgctatgcc     1560

ctggagaatt ttgtggagaa cctagggccc aaggtgcagc cctaccttcc ggagcttatg     1620

gaatgcatgc tgcagcttct gaggaacccc agcagtcccc gggccaagga gctggctgtg     1680

agcgccctgg gagccattgc tacggctgcc caggcctcgc tgctgcccta cttccctgcc     1740

atcatggagc acctgcggga attcctgtta acaggccgtg aggaccttca gcctgtgcag     1800

atccagagcc tggagacact gggggtgctg gcacgagcag tgggggagcc catgaggccg     1860

ctggctgagg aatgctgcca gctgggtctg ggcctctgcg accaggtaga cgaccctgac     1920

ttgcggcgct gcacgtacag cctatttgca gccttatcgg gtctgatggg tgagggcctg     1980

gcgccccact tggaacagat caccacgctc atgctgctgt cactgcgttc caccgagggc     2040

attgtgcctc agtatgacgg gagcagctcc ttccttctgt ttgacgatga gagtgatggg     2100

gaagaagagg aggagctcat ggatgaggat gtggaagaag aggatgactc agagatctca     2160

gggtacagcg tggagaatgc cttcttcgat gagaaggaag acacctgtgc tgccgtgggg     2220

gagatctctg tgaacaccag tgtggccttc cttccataca tggaaagtgt ctttgaagaa     2280

gtatttaaac tgctggagtg ccctcacctg aatgtgcgga aggcagccca tgaggctctg     2340

ggtcagtttt gctgtgcact gcacaaggcc tgtcaaagct gcccctcgga acccaacact     2400

gctgctttgc aggctgccct ggcccgagtc gtgccatcct acatgcaggc agtgaacagg     2460

gagcgggaac gccaggtggt gatggccgtg ctggaggccc tgacaggggt gctccgcagc     2520

tgtgggaccc tcacactgaa gccccctggg cgcctcgctg agctctgtgg cgtgctcaag     2580

gctgtgctgc agaggaagac agcctgtcag gatactgacg aggaggagga agaggaagat     2640

gatgatcagg ctgaatacga cgccatgttg ctggagcacg ctggagaggc catccctgcc     2700

ctggcagccg cggctggggg agactccttt gccccattct ttgccggttt cctgccatta     2760

ttggtgtgca agacaaaaca gggctgcaca gtggcagaga agtcctttgc agtggggacc     2820

ttggcagaga ctattcaggg cctgggtgct gcctcagccc agtttgtgtc tcggctgctc     2880

cctgtgctgt tgagcaccgc ccaagaggca gaccccgagg tgcgaagcaa tgccatcttc     2940

gggatgggcg tgctggcaga gcatgggggc caccctgccc aggaacactt ccccaagctg     3000

ctggggctcc tttttcccct cctggcgcgg gagcgacatg atcgtgtccg tgacaacatc     3060

tgtggggcac ttgcccgcct gttgatggcc agtcccacca ggaaaccaga gccccaggtg     3120

ctggctgccc tactgcatgc cctgccactg aaggaggact tggaggagtg ggtcaccatt     3180

gggcgcctct tcagcttcct gtaccagagc agccctgacc aggttataga tgtggctccc     3240

gagcttctgc gtatctgcag cctcattctg gctgacaaca agatcccacc agacaccaag     3300

gccgcactgt tgctgctcct gacgttcctg gccaaacagc acaccgacag ctttcaagca     3360

gctctgggct cactgcctgt tgacaaggct caggagctcc aggctgtact gggcctctcc     3420

tagactgcag gctgcagcca gtccagagag aatagagcct gcccaggcct taagaccacc     3480

tctcagccca gttcagttct gccttaccaa agattctgag actcataccc atttggagcc     3540

agccccactt gctgccttac agggctgtcc ctgaggctgg atctgttaca aatgagtcat     3600

gacatcatac tgtaataaaa gcagcttgtt ttctgcttga acaata                    3646


<210> 1340
<211> 7441
<212> DNA
<213> Homo sapiens

<400> 1340
gaggcggggc caggacggcg ggaccggccg ctgggtccca gcgagggctg agccgggcgg       60

tgggaggagg tcaggatggt gggggaacgg catgctgggg acctcatggt gcccttaggg      120

cctcggctgc aggcatatcc tgaagaactc attcgacaga ggcctgggca tgacgggcat      180

cctgaatacc tgatccgatg gagtgtcctg aagtgtgggg aagtgggcaa agtgggtgtg      240

gaagaaggca aagcagagca catcctcatg tggctgtcgg ctcctgaggt ctacgccaac      300

tgccctgggc tgttaggtga gcgggcacta tctaagggac ttcagcacga accagctggg      360

gtttcaggaa gctttcctcg agatccagga ggcctggatg aagtggcaat gggagagatg      420

gaggctgatg ttcaggcgct ggtacgcagg gcggccaggc agctggcaga aagtgggacc      480

ccaagcctca cggccgctgt gcttcacacc atccacgtgc tcagtgccta cgccagcatc      540

gggcccctca ctggtgtctt cagggagaca ggagccctgg acctgctcat gcacatgtta      600

tgcaatcctg agcctcagat ccgccggagt gcaggcaaaa tgctgcaggc tctggcagcc      660

cacgatgctg ggagtcgggc tcacgtcctt ctatcactga gccagcaaga tggcatcgag      720

cagcacatgg attttgacag tcgctataca ttgctggagc tgtttgcaga aaccacatcc      780

tctgaagaac actgcatggc ctttgagggc attcatctgc ctcagatccc aggaaagctg      840

cttttctcct tggtgaagcg ctacctttgt gtcacgtccc tcctggatca gctgaatagc      900

agtccagagc tgggagctgg agaccaaagc tccccatgtg ccacaagaga gaaaagccgg      960

ggacagcggg aactggagtt cagcatggct gtgggcaacc tcatctctga gcttgtgcgg     1020

agcatgggct gggcccggaa cctcagcgaa cagggcatgt cacctccccg gccaacccgg     1080

tccatctttc agccctacat ttcaggcccc agccttttac tccccaccat tgtcaccacc     1140

cccagaagac aagggtgggt cttccgccag cgctctgaat tctccagccg tagtggctat     1200

ggagaatatg tgcagcagac actccagcca gggatgcgag tgcggatgct ggatgattat     1260

gaggagatca gtgctgggga cgagggcgag ttccggcaga gcaacaacgg cattccccct     1320

gtgcagaccc tgggtgaaaa ggccctaggt gagatctctg tgtccgtgga aatggccgag     1380

agtctgctgc aggttctcag tagtcgattt gagggcagca ctctcaatga cctgctcaac     1440

tcccagatct acaccaagta tgggctgctg tctaatgaac caagcagctc gtctacttca     1500

cgaaatcact cctgtacccc agatccagaa gaggagtcca agtcggaggc cagcttctca     1560

gaggaagaga ctgagtccct caaagcaaag gccgaggccc ctaagacaga ggccgagccc     1620

accaagacaa ggaccgagac ccccatggca cagagtgatt ctcagctgtt taaccagctt     1680

ctggtgactg aggggatgac cctgcccact gagatgaagg aggcagccag tgaaatggcc     1740

agagccttgc ggggtcccgg tcctcgcagc tccctggatc agcatgtggc agcggtcgtg     1800

gccactgtgc agatatccag cttggacaca aacctgcagc tttcagggct ctctgccctc     1860

tctcaggctg tggaggaggt cactgagcgg gaccaccctc tggtccgtcc tgacagatcg     1920

ctgagagaga agctagtgaa gatgctggtg gagctgctga ccaaccaggt gggagagaag     1980

atggtggtcg tgcaggccct gcgcctcctt tacctgctca tgaccaagca cgagtggcgg     2040

ccgctctttg ccagggaggg tggcatctat gctgtgctgg tctgcatgca agaatataag     2100

acttctgtct tggtgcagca ggctgggctg gcggcactga agatgctggc cgtcgccagc     2160

tcctcggaga tccccacttt tgttactggc cgagattcta tccactcttt gtttgatgct     2220

cagatgacca gagagatctt cgccagcatc gactcagcca cacgcccggg ctctgagagc     2280

ctgctcctca ctgtccctgc agccgtgatc ctgatgctga atactgaggg gtgctcttct     2340

gcagcgagaa atggcttact cctgctcaac ctacttttgt gcaaccacca cactctggga     2400

gaccagatta taacccaaga gctgagagac acgttgttta ggcactcagg gatagcacca     2460

agaacagaac ctatgcctac cacacgcacc atcctcatga tgcttctcaa tcgctactca     2520

gagccgccgg gcagccctga gcgtgcagca ctagagaccc ccatcatcca gggtcaggat     2580

gggtcccctg agctactgat tcgatccctg gttgggggcc catctgcaga actactcctg     2640

gacttggagc gtgtgctgtg ccgtgagggc agccccggag gtgccgtgag gcccctcctc     2700

aagcgcctcc agcaggagac ccagcctttc ctcctgttgc tgcggactct ggatgctccg     2760

gggcccaaca agactctgct gctgtctgtg ctgagggtca taacccgact gctggatttc     2820

cctgaggcaa tggtcctccc ctggcacgag gtcttggagc cctgcctcaa ctgcctgagt     2880

ggccctagca gtgactccga gattgttcag gagctgacct gcttcctaca tcgcctggcc     2940

tcgatgcata aggactatgc tgtggtgctc tgctgcctgg gagcaaaaga gatcctctcc     3000

aaagtcctgg acaagcactc agctcagctg ctgctgggct gtgagcttcg ggacctggtg     3060

acagagtgtg agaagtacgc acagctctat agcaacctca cctccagcat cctggccggc     3120

tgcattcaga tggtgctggg ccagatcgaa gaccacagac gaacccacca acccatcaat     3180

atccccttct ttgatgtgtt cctcaggcat ctctgccagg gctccagtgt ggaagtgaag     3240

gaggacaagt gctgggagaa ggtggaggtg tcctccaacc cgcaccgagc cagcaagctg     3300

acggaccaca accccaagac ctactgggag tccaacggca gcaccggctc ccactacatc     3360

accctgcaca tgcaccgtgg tgttcttgtt aggcagctca ctttgctggt ggccagtgag     3420

gactcaagct acatgccagc cagggtggtg gtgtttgggg gtgacagcac cagctgcatc     3480

ggcactgagc tcaacacggt gaatgtgatg ccctctgcca gccgggtgat cctcttggag     3540

aacctgaacc gcttctggcc catcatccag atccgcataa agcgctgcca gcagggcggc     3600

attgacaccc gggttcgggg tgtggaggtc ctgggcccta agcccacatt ctggccactg     3660

ttccgggagc agctgtgtcg ccgaacatgt ctcttctaca caattcgggc acaagcctgg     3720

agccgggaca tagcagagga ccaccggcgc ctcctccagc tctgtcccag actgaacagg     3780

gttttgcgcc acgagcagaa ttttgctgac cgcttcctcc ctgatgatga ggccgcccag     3840

gcactgggca agacctgctg ggaggccctg gtcagccccc tggtgcagaa catcacctct     3900

cccgatgcgg aaggcgtgag tgccctggga tggctgctgg atcagtactt agaacagaga     3960

gagacctctc ggaacccctt gagtcgagca gcgtcctttg cttctcgagt tcgtcgcctt     4020

tgccacttgc tggtgcatgt ggaacctcct cctgggcctt ctcctgagcc atccactcgg     4080

cccttcagca agaacagcaa gggtcgggac cggagcccgg cgccttcgcc agtgcttcca     4140

agcagcagcc tgaggaacat aacccagtgc tggctgagcg tggtgcagga gcaggtcagc     4200

agattcctgg ctgcagcttg gagggcccca gactttgtgc ctcgttactg taaactctat     4260

gagcacttgc agagagcagg ctccgagctg tttgggcctc gggcagcctt catgctggct     4320

ctgcgcagtg gcttctctgg cgccttgctg cagcagtcct tcctcactgc tgctcacatg     4380

agtgagcagt ttgccaggta cattgaccaa cagatccagg gtggcctgat tggtggagcc     4440

cctggagtgg aaatgctggg gcagcttcag cggcacctgg aacccattat ggtcctttct     4500

ggtctggaac tggccacaac ttttgagcac ttctatcagc attatatggc ggaccgtctc     4560

ctgagctttg gttcgagctg gctggagggg gctgtgctag agcagattgg cctctgtttt     4620

cccaaccgcc tcccacagct gatgctgcag agcctgagca cctctgagga gctgcagcgc     4680

cagttccacc tcttccagct ccagcggctc gacaagttgt tcttggagca ggaagatgag     4740

gaggaaaaga gactagagga agaggaggag gaagaggagg aagaggaagc tgagaaagaa     4800

ttatttatcg aagatccaag tccagccatt tctatactgg tcctgtcacc acgctgctgg     4860

cccgtctccc cactctgcta cctgtaccat cccagaaagt gccttcccac agaattctgt     4920

gatgcccttg accgtttctc cagtttctac agccagagtc agaaccatcc agtcctggac     4980

atgggaccac atcggcgact gcagtggacg tggctgggcc gggctgagct gcagtttggg     5040

aagcagatac tgcatgtgtc caccgtgcag atgtggctgc tgctgaaatt caatcagaca     5100

gaggaggtgt cagtagagac cttgctgaag gattctgacc tctccccaga gctgctgctc     5160

caggcactcg tgcccctcac ctcagggaat ggccctttga ccctgcatga gggccaggac     5220

tttccacacg ggggtgtgct gcggcttcat gagcctgggc cccagcgcag tggggaggcc     5280

ctgtggctga tacctcccca ggcatacctg aacgtagaga aggatgaagg ccgaaccctg     5340

gaacagaaga ggaatctctt gagctgtctt cttgttcgta ttctcaaagc ccatggggaa     5400

aagggcctcc acattgatca gctggtttgt ctggtgctgg aggcctggca gaagggtcca     5460

aatcctcctg gaaccctggg ccacactgtt gctgggggtg tggcctgtac cagtacagat     5520

gtcctctctt gcatcctgca cctcttaggc cagggctacg tgaaacggcg tgatgaccgg     5580

ccccagatcc tgatgtatgc cgctccagag cccatggggc cctgccgggg tcaggcagat     5640

gtccctttct gtggcagcca gagcgaaacc tccaagccca gcccagaagc tgtggctacc     5700

ctggcatctc tacagctgcc tgcaggccgc accatgagcc cccaggaagt agaagggttg     5760

atgaagcaga cggtgcgtca ggtgcaggag acgctgaact tagagccaga tgtcgctcag     5820

caccttttgg ctcattccca ctggggcgct gaacagctgc tgcagagcta cagtgaggac     5880

cctgagccac tgctgctggc agctgggctg tgcgtacacc aggctcaggc tgtacccgta     5940

cggcctgacc actgccccgt ctgtgtgagc cccctggggt gtgacgacga cctgccctct     6000

ctctgctgca tgcactattg ctgtaagtct tgctggaatg agtacctgac aactcggatc     6060

gagcagaacc ttgttttgaa ttgcacctgc cccattgccg actgccccgc ccagcccacc     6120

ggagccttca ttcgtgccat cgtctcctcg ccagaggtca tctccaagta tgagaaggcg     6180

ctcctgcgtg gctatgtgga gagctgctcc aacctgacct ggtgcaccaa cccccagggc     6240

tgcgaccgca tcctgtgccg ccagggcctg ggctgtggga ccacctgctc caagtgtggc     6300

tgggcctctt gcttcaactg tagcttccct gaggcacact accctgctag ctgtggccat     6360

atgtctcagt gggtcgacga cggtggctac tatgacggca tgagcgtgga ggcgcagagc     6420

aagcacctgg ccaagctcat ctccaagcgc tgtcccagct gtcaggctcc catcgagaag     6480

aacgaggggt gcctgcacat gacctgtgcc aaatgtaacc atggattctg ctggcgctgc     6540

ctcaagtcct ggaagccaaa tcacaaagac tattacaact gctctgccat ggtaagcaag     6600

gcagctcgcc aggagaagcg gtttcaggac tataatgaga ggtgcacttt ccatcaccag     6660

gcgcgggagt ttgctgtgaa cttgcggaac cgggtgtctg ccatccatga agtgcccccg     6720

cccagatcct tcaccttcct caatgatgcc tgccagggac tggagcaggc tcggaaggtg     6780

ctggcctacg cctgcgtgta cagcttctac agccaggacg cagagtacat ggatgtggtg     6840

gagcagcaga cagagaacct ggagctgcac accaatgccc tgcagatcct cctggaggaa     6900

accctgctgc ggtgcagaga cctggcctcc tccctgcgcc tcctgcgggc cgactgcctc     6960

agcacgggca tggagctgct ccggcggatc caggagaggc tgcttgccat cctgcagcat     7020

tctgcccagg atttccgggt tggtcttcag agtccatcag tagaggcctg ggaggcaaaa     7080

ggacccaaca tgcctggcag tcagccccag gcctcctcag ggccagaggc agaagaggag     7140

gaggaagacg atgaggatga tgtgcccgag tggcagcagg atgagtttga tgaggagctg     7200

gacaatgaca gcttctccta cgatgagtct gagaacctgg accaagagac tttcttcttt     7260

ggtgatgagg aagaggatga agatgaggcc tatgactgag ggggcagatg caggaaacac     7320

ctagagcagc cccagagtca cggggctgag ggggcgggag ctgcccctgt catagggagg     7380

gggattccca gcgtctgtag tgcttcctgt ttgctgaata aaggtctctt tctcacacac     7440

a                                                                     7441


<210> 1341
<211> 4857
<212> DNA
<213> Homo sapiens

<400> 1341
cctgtgctgg atcctgggcg gcctgagggg tacggagact ctgggggagg gagacggcag       60

cggcatggcg gccgggtgta agacgcccga ccctcctctt ccctgtcttc gccgccgccg      120

ctgctggagt cactgggacc ctgtagtctg cgtgtgttag ttgtaatccc gccgccctcc      180

tgtcagccct ccgctccgcc ggccctcctt ccttccgccg ccgcagccag cccgagggtc      240

ggccggctgt gtaacactct cccaccccac ccaccagccc gcgggccagc accatggagg      300

acgtgaagct ggagttccct tcccttccac agtgcaagga agacgccgag gagtggacct      360

accctatgag acgagagatg caggaaattt tacctggatt gttcttaggc ccatattcat      420

ctgctatgaa aagcaagcta cctgtactac agaaacatgg aataacccat ataatatgca      480

tacgacaaaa tattgaagca aactttatta aaccaaactt tcagcagtta tttagatatt      540

tagtcctgga tattgcagat aatccagttg aaaatataat acgttttttc cctatgacta      600

aggaatttat tgatgggagc ttacaaatgg gaggaaaagt tcttgtgcat ggaaatgcag      660

ggatctccag aagtgcagcc tttgttattg catacattat ggaaacattt ggaatgaagt      720

acagagatgc ttttgcttat gttcaagaaa gaagattttg tattaatcct aatgctggat      780

ttgtccatca acttcaggaa tatgaagcca tctacctagc aaaattaaca atacagatga      840

tgtcaccact ccagatagaa aggtcattat ctgttcattc tggtaccaca ggcagtttga      900

agagaacaca tgaagaagag gatgattttg gaaccatgca agtggcgact gcacagaatg      960

gctgacttga agagcaacat catagagtgt gaatttctat ttgggaagga gaaaatacaa     1020

gagaaaatta taatgtaaaa tggtaaaaac ataagtagtt tttttttcaa ttacatgttg     1080

cttccagaca tacttctctg caacttgttg agcaacattt taagatgttg gacttctgca     1140

atagatgaca ctgatggttt tactcctttt tttaaaaaca catgcgcgcg cacacacaca     1200

tgctttacaa gttttattat aaaccaagaa ttttggactt gcaaagaggt attattgcaa     1260

taatgcactt ttcatacttg aaatttattt gtatgatata aagttattac tttaaacaaa     1320

atgcaagtat ggggggattg tttataaagt ttgggtaatt tataacaaaa tttgctaagg     1380

tttgctaaaa attcattttt ctgttctata tattacattt ttaacataat tttacagttc     1440

aattttatga tggagcctct tacagaaaca ttaacaaaat gcaggaatct gccacatttc     1500

ttttttagta taacttaata gcttaattac cattttattt tttatacttc ttccattatt     1560

aatctttaaa tcatgatcct aattagctgt ccttacttta acttgatcta attattgctt     1620

cctttcttat tactttccta atttttctat attttaaaaa ctacagtttc catgataaaa     1680

ggaaaacgtt ttgatttata gtaccaagtg cttaaacaca aggatagtgt tagattttcg     1740

agtgactttc ctttttgcat tttttggcag taaaagccaa acgttgtatt tgttcttttc     1800

agagttgtcc agcccttttt tcctttgtcc aaaatgattc taaatagaat ctaataaacc     1860

aatgtagcat tatttttttc taaatgaagc cccaaaaaag aaaagtgcct tgcatcattt     1920

aaaaaaaata attaaatcct catggcctct aaattagtat gtagaacact gaaaagttct     1980

taacattttt gtgtaatttc ctttcttttt aaaccataaa ttagtttaaa ctgaaagtac     2040

gaggctggaa gaaatattag taaattattt ggaatataga atgtttactc tttcttttta     2100

tgttgtctta atgattctgt gagattgttc cggctcaaac agaagctttt ctttggggaa     2160

ggtgatttgt gggagactag tgtattttaa attagcattt taatccattc ttgacattca     2220

gttagtccag atctgcccca taatttgctt tagtaaagtc actttatgga tttttggcta     2280

tgttttagtt tgtgtgtata aaagttctaa gaaaacattt ttgctatttt aagtatgtaa     2340

gggaagagag gagtgttttt aactttttat agttgatgac tttagggtag cacaaacaaa     2400

actcctttgt atctaacttt tctcaatcct ctcttgaggt gctttactaa tgggaatgat     2460

ttctgtatgt tcccttggta ccaagaggta ctatgcaaag taacctatta caccaagtta     2520

cttgctttgc tttcctctct atgatgtgat aatacagtaa aagctttctt acccagcata     2580

gtgggagagt ggagattaat taaaattgtt aattaagagt taattcctat tgacccaggt     2640

gatatttctc ttctgatttc cctccccttc ccttctctta tcttaccact gtgaaaacag     2700

catattgtta atctcgttgt cgtccagtat tctgctttgt gattaggtct tttgatgtac     2760

agtggtctag tggagtcaag attcgcattg ggttttctaa aattccagtt gataaaagtt     2820

ccagataaca cagctttcct gtatatagat cactattggg caggtcagca aagatctctt     2880

acagtgtaat aataatctat gatgcttcat ttagcagaaa ctctgcttaa aagaatcttc     2940

ataatagtaa gtttaggttt taaaaacttg tttcataaat atacatatat cctctctagt     3000

agtctggcca aaagaacaga ttttgttatt gataatttgt agctggtaat tttccacatt     3060

ttctatccac tgtaattttt atgttgtcac tgaagtgcct gcccagtact gtatattaca     3120

gtctctcaca aacactggga aaagggactg tcatcatctt gagtactctg tgtgtatata     3180

tatatatata gatagataga tttttttttt tttttgagac agagtctcta atgtcaccca     3240

ggctggagta cagtggcaca atcttggctc actgcaacct ccacctcctg ggttcaagtg     3300

attttcctgc ctcagcctcc caagtagctg gggttagagg cacatgccac catgcctggc     3360

taatttttgt agttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaac     3420

tcctgacctc aagtgatcca cccacctcgg cctcccaaag tgctgggatt acaggcgtga     3480

gccactgcgc ctggctgagt acaatattaa tgtagacaaa ccatgaagtt tattatttca     3540

tataagaaca ttacaggttt gttttttctt gcatgtctgt ccacctaatg tttaagtagt     3600

tctggtagct cttcctattc tttattctat ttgattccat ttctgtgatt cttttattac     3660

cactgatgtt ttgtgatagt taactatgat aaatttaact gatcatgatt tatcttctag     3720

agtatttaaa taatgtatga gtgaccaccc aattccaaca ttaaaagtgt aatctgggcc     3780

cataatttat agtgaaattg tatcaaaaca tagggaaact gtattactgt ccattttgaa     3840

aatatgaaac ttgagtattg aaaatattca aacatggaat ggcagtattc taatttcagt     3900

tagttggttc atgttaattt cttacctgtt agatgtttaa actgcagtga cctttacttg     3960

tatctactct gtggtggaaa tgttaaacca tgatagcttt tgctaccaac tcaaccactt     4020

aacttttaga gcagttttgg ggagagttta tgcttcatct gagtttagaa gtaatgtcag     4080

aaaatgttaa gcatgtctgt attaagaaaa tataaggttt ctaattgtct tattaatatg     4140

gtaattcaag tgaattagaa atatttaact gcaatcttga attataaagt tgagatatat     4200

atatatatgt atcaagatct caacttgatg taaagtaaat gagcagttac ctggcggatt     4260

tttttttttt taaataactg atttaatcca taatcccata acaaacatag cttcacctca     4320

gtattttctt tctttctttg ttcaacagtg ctccgataag ggaatgctag aaaatagatg     4380

agaagtactg aaagaccttt ttttttaatt gattagaaaa gtaagtctct agggtctttg     4440

aatgctggaa tttttttttt tttttttgtc tttcccatct gtggcagcta aaacaaaaat     4500

cactcaaaat attcaggttt acatgttagc tctctctcat agggagctgc catacctcac     4560

agttcaaagt gtattctata gatcagtaac attatactga catgtaattg caatttacta     4620

tgcagcaaaa atgattcaag aagaaaaata acctacagtg tctgtatacc tttgtataca     4680

caattgctta agttactctg cttttaacat ttgtacttgg ataaaatgct tatgtctgta     4740

taggaatgtc acagtgcaag atgctgctag cccaggcaca aagtattaaa attattttgt     4800

gaagattggt ggttgtatta aaactgctgt gccattatac ctccaaaata ttgaaaa        4857


<210> 1342
<211> 2707
<212> DNA
<213> Homo sapiens

<400> 1342
ggaaatggct gcgagaccct agaggcctgc ggcctgcgga gcttactcca cgggaacagc       60

ctctagataa tctgagttgt tgaaaatacg aagcctgtta ctcgtgaaca gtggctgaca      120

acagtgttgt tgtgagcctg gctgtctgct tggacccaga ggtttcgtct gccagggttt      180

ttggttgtat ttaggatttc agggaaaagt gtccaagctt tcagtgttgg agcaggtatg      240

gacgacaaag gcgacccgag caatgaggag gcacctaagg ccatcaaacc caccagcaaa      300

gagttcagga aaacatgggg ttttcgaagg accactatcg ccaagcgaga gggcgcaggg      360

gacgcggagg ctgacccact ggagccgcca cccccacagc agcagctggg cctgtccctg      420

cggcgcagtg ggaggcagcc caagcgcact gagcgcgtgg agcagttcct gaccattgcg      480

cggcgccgcg gcaggaggag catgcctgtc tccctggagg attctggtga gcccacgtcc      540

tgccccgcca cagacgccga gacagcctcc gagggcagcg tggaaagcgc ttctgagacc      600

agaagcggcc cccagtctgc ttccacagct gtgaaggaac gaccagcctc ttctgaaaag      660

gtgaaaggag gggatgacca cgatgacacc tccgatagtg acagcgatgg cctgaccttg      720

aaagagcttc agaatcgcct tcgcaggaag cgggaacagg agcccactga gaggcccctg      780

aaagggatcc agagtcgcct gcggaagaag cgccgggagg agggtcccgc cgagactgtg      840

ggctccgagg ccagtgacac tgtggagggc gtcctgccca gtaagcagga gcccgagaac      900

gatcaggggg ttgtgtccca ggctgggaaa gatgacagag agagtaagtt ggagggaaag      960

gcggctcagg acatcaaaga tgaggagcct ggagacttgg gccgaccgaa gcctgaatgt     1020

gagggttacg accccaacgc cctgtattgc atttgccgcc agcctcacaa caacaggttt     1080

atgatttgct gtgaccgctg tgaagaatgg tttcatggcg attgtgtggg catttctgag     1140

gctcgaggga ggcttttgga aaggaatggg gaagactata tctgcccaaa ctgcaccatt     1200

ctgcaagtgc aggatgagac tcattcagaa acggcagatc agcaggaagc taaatggaga     1260

cctggagatg ctgatggcac cgattgtaca agtataggaa caatagagca gaagtctagc     1320

gaagaccaag ggataaaggg tagaattgag aaagctgcaa atccaagtgg caagaagaaa     1380

ctcaagatct tccagcctgt gatagaggcg cctggtgcct caaaatgtat tggccccggg     1440

tgctgtcacg tggcgcagcc cgactcggtg tactgcagta atgactgtat cctcaaacac     1500

gccgcagcga caatgaagtt tctaagctca ggtaaagaac agaagccaaa gcctaaagaa     1560

aagatgaaga tgaagccaga gaagcccagt cttccgaaat gcggtgctca ggcaggtatt     1620

aaaatctctt ctgtgcacaa gagaccagct ccagaaaaaa aagagaccac agtgaagaag     1680

gcagtggtgg tccctgcgcg gagtgaagca ctcgggaagg aagcagcttg tgagagcagc     1740

acgccgtcgt gggcgagcga tcacaattac aatgcagtaa agccagaaaa gactgctgct     1800

ccctcgccgt cactgttgta taaatgtatg tatcacctag gggttggcct cctggacccc     1860

tcccgttctt tctggatagc catcccctgg gcctgtccag gactgggagt tgcagctttg     1920

tgttaagctg atcacagaca ccggctgcac catcagcggg aagcagagcc catgtccagg     1980

atgcctcctg ctgccctgtg tccatcccta gtctgtcagg acttcctgtc actgttttcc     2040

aaagctgtaa acctcactgg tgaacgttca ccttaatgat tgattcttta atctctgttt     2100

tcactctcag gctctggtaa gtattcgtat tctcttcatc ccagtctgat tgcatagcca     2160

cactgcccgg cacgccacat ccacccctgt ctgcacatga gttgttctga caacagcgct     2220

gtatacgctt cagtttttcc acattgtcca cggccagcac atgaaagcat cacttctttt     2280

ttatgttgtg ggaatctttg caagttagtg ttgcatctga ttttcaggtg tacatttatt     2340

tttgactggg cagatagggg attttttttt ttccatgtcc gattcacacg ctacacaccc     2400

acatgaacac attcgaactt cgaaggccac acactcctgc ttcataggcc ccacggtaag     2460

tgagttcaca cctagaacac tgtcctgacc gcaggacgcg tgccttggac ttggtattct     2520

acatgtgact ggctttcttg ccctcgtctc ttgaatgttt agactcttaa gatcatatcc     2580

tgccccaaat ttcaaattaa tgaaatgaag atatttcaaa cagatctttg aaacctcaga     2640

ttctgtggtg caattttaat gttttcttgt ttctcagttt tctgctataa aactattttc     2700

aattcag                                                               2707


<210> 1343
<211> 943
<212> DNA
<213> Homo sapiens

<400> 1343
aacctcacga ggccttacgt gcctagagcg gttcctctcc gtggcgccct accgccttcg       60

gcgcgaaggt ggctggtgcg taccgtcccg aaccctagga gccgaggtga gcgccgcgaa      120

gacccccgac attaagaagt ggtgtccacc gcagccccct taagccggat accctccccc      180

accccgagga gcaagcctgc cttccgccac gcgccgcccg tcttccgcgc ccgcgcagaa      240

cctcgcggct gtgcccgcct aaagccacgc ccatcctctc ttggccacgc cctcagagac      300

tcctcccctg tcgcccagat cccacccgca ggaccccaaa acccaatgat cctgcagcag      360

cccttgcagc gaggccccca gggaggggcc cagcgcctcc cgcgggccgc cttgggggtg      420

acttggggcc tggacgccag ggagcctctg cgcaagcagt ttctgtctga ggagaacatg      480

gccacccact tctctcaact cagcctgcac aatgaccacc cctactgcag cccccccatg      540

accttctccc cagccctgcc cccactcagg agcccttgct ctgagctgct tctctggcgc      600

tatcctggca gcctcatccc tgaggccctc cgtctgctga ggctggggga cacccccagt      660

cccccctacc ctgcaacccc agctggggac ataatggagc tctgagtgct ggtggacagt      720

gcccctccca ccttccttct tccccacaac agaagagacc agcgactccc gcaaagggac      780

aaggttcctc cctctcctgc agagtaggca tctgggcacc aagaccttcc ctcaacagag      840

gacactgagc ccaacggagt tctgggatgg gaggggtggg agcatgggaa gggaggcatc      900

ccacccccaa gaagaactga ataaagattg ctgagcaaag gaa                        943


<210> 1344
<211> 3205
<212> DNA
<213> Homo sapiens

<400> 1344
ttctaacagc tgggtgcggg tggagctgcg ggcgatcgcc agctcgagtg cagattcctt       60

gctgtgaccg aggttcagag tgagctctgt cggtgtgtca gtttgcctct tcaggtgatt      120

gcacgtctgt gtgcgagtct ctccgtgtat gggtggctat gattagggtg agcctcagac      180

tggaactcaa gtctaagttc attcactgct ccagcaggca ctcttcaatg aaacctcatc      240

agcagatcgg gctctcttcc cttgccttgc ctcctaaccc ccctaggcca ggtgaggggg      300

acagggtact gggaggtaag aaggaactct tctgcaagga gggctctcac gtctgtctta      360

ggcctgctcc ttaccagagt ctttggggaa gcagtaggga gggcctgagg gtctcaggaa      420

aggctctctg ctggtctggc tctgctctgt agctccatct atttccctgt cccaggtcct      480

ttcttcctcc taaccccatt gactctgacc atcccctgcc cagagcctga ggtcccttct      540

ctggcccctc tgctgggctg gcccatgcag gtgaggcccc gcatctggca tcctggaact      600

ggcagttgga gcctgagcta tgggcaaggt cacttcgaca gcagttgaat gcccagctcc      660

tcatggtccc ggaggagagg agggtaggtt tgtcttctga tgagacatca tctgattccc      720

ttaagtcttg gcactccata tgtgtcttgg acagcaaaga acagcccttg gcctgccagc      780

agaaacagag gcagttcgtg aagccagtga ctgagtcaga gcagcccaca gtgctggaac      840

tcctgctagc tgagctccga actctgttct cagctgtgtt gcaggacagt agccctgcag      900

cttggcgcta tcttcatgca gtactgggtc tactgcctcc atatcgtgag ttgctagttg      960

gccaccttga tttgctgccc ttcctggagc agctgtactg ctgggcaccc tgggtccaaa     1020

cccacctcca tctggacctg ctaggtgcca ttgtccaggc ctttcctcca gacagctctt     1080

tgttagacag tgcttcccat gctgactgct gtccccagaa gcggaggctc catcacaggc     1140

ccccatgccc agcttgccct tttgtgcagg cccagtggag caggcagcaa gtaaaggagg     1200

agctggccac ctggctgcga ccattgacac tgcctgagct acagcgctgc ctgggcattg     1260

ttggtgctca ggtggcccta gaagaggctg tgtggctgga tggacttagt ctccttccct     1320

tggcactggc agcggacatc cctgtacggt atgaaagcag tgacactgac aatgcagagg     1380

tggagcctgt tggaagaaaa gagaccaggt ctcagcttga ctatgaagtt cccagggaaa     1440

aggccttcca aaagagcagc accggctttt cacctgagac ttccttcctg gatagccagg     1500

tgatgactgc tctgaagatg gagagatacc tgaagaagat ccacttcctc tatctcaatg     1560

tggctcccag ccggtacttt aggccttaca gcctgatggt ggtgccaccc gacaaggtga     1620

atcccgagca ctacatcttc tctccctttg ggatcttgca tgtacatcct gtggaaggta     1680

gcgagacgat gacactgggt acctggcacc atcactgtgt tctctggcag cagctccagt     1740

tcattccatt ctttaagtat tgcctcttac gcaagtcctt tacctgttgg aagaagaatg     1800

tgagattaca ggggctgcat cgactccaga aattcctaga gaatcatctg ctcttggctg     1860

tgccccactt tggagctggg ctactccata ttagcaggct tctgcaggag ctacactctg     1920

tgtcctggct accccaggaa ctggatcggt gctatgagct gctggacctg cagacggctc     1980

tagccgagga gaagcataag gctctacggc tgctccatcg ttgcctaaac ctctgcacat     2040

ccattcttcg actggttcac gaggacacat accacatgca acagtgccta caggagcgag     2100

tacaaaactg tgacaggatc aggacaggcc aaggctccat ataccttcag agggtacagc     2160

acaagcaact ggagcagaag ctgaagcaag cagaggcctg gtggctgcag ctgggaaagt     2220

ttgcccgcct ggttgactac atgatttgtc agagcctcat ttctgtcttg gaagagcaga     2280

taacctcttt tgtggccaac atccttcaag ccccaaggca gaaacccttt ctctcatcac     2340

agctggtctt tgatgatcat ggtcaactgt ctcatgtgcc ctgtgttgaa aatatgatcc     2400

agactctaac tggaggccta cagtctgtca agacctctgc cttgcaggta ttctgaattg     2460

ggcagagagc tggctgtggg aattcccagt tcctatcctc tgagtaatca gaagctcaca     2520

acctggtttg aatccctcat tgctttccca tttctgcccc ttctccatat cctggcatga     2580

aggtagtgca gtctgcagac ctgaagacct cctcggattc cctgtattct gaaggtattt     2640

agggagacct aggcaggggg taggaaggct gaaggaggga aagggcacaa gtactaatgg     2700

catgggaaga aggcaggagg tccaggctat agagtcaggc actgggtgtg gatggagcag     2760

ctctaacctg ggtactgcac atatgtgttg tgggtagaaa ggtcagggaa tgtttttgct     2820

cacaaattca cgtggttatg tgtatgtgcg tgcaatgaga gggtgtatga aagagtgtga     2880

gtacattgtc cttccaaacc tgattcatcc caaactctgt gaggtttttc tccagtgcca     2940

taattgcatt tcatttacta ctgaatttta ttgctaagta aatttgtact tgtttgaaga     3000

gctctgcttg ctcaacactt gctttatgtc atatagctct ttttcatttc atatggatta     3060

attcattgta ttgaaatatt ttatggttac caattattat tggttatcag tcttcacact     3120

tattaaccat cagcgtggaa acacatcttc acatttccct tatttaggat actaatgctg     3180

tcacaaataa aatcattaaa tgcaa                                           3205


<210> 1345
<211> 2498
<212> DNA
<213> Homo sapiens

<400> 1345
gagaaggctt gggctcgcgc cgctgaagtc ggcttacccg ctggccgcct cctgacaagc       60

gggagggatc cgcggtggac ccagggaagc ggaggagcct ggcggccacc ccctcttcct      120

cacttccctg tactctcatc gctctcggcc tccgacacga aaaggaagca aatgagctga      180

tggaagatct gtttgaaact ttccaagatg agatgggatt ctccaacatg gaagatgatg      240

gcccagaaga ggaggagcgt gtggctgagc ctcaagctaa ctttaacacc cctcaagctc      300

tacggtttga ggaactactg gccaacctac taaatgaaca acatcagata gcgaaggaac      360

tatttgaaca gctgaagatg aagaaacctt cagccaaaca gcagaaggag gtagagaagg      420

ttaaacccca gtgtaaggaa gttcatcaga ccctgattct ggacccagca caaaggaaga      480

gactccagca gcagatgcag cagcatgttc agctcttgac acaaatccac cttcttgcca      540

cctgcaaccc caatctcaat ccggaggcca gtagcaccag gatatgtctt aaagagctgg      600

gaacctttgc tcaaagctcc atcgcccttc accatcagta caaccccaag tttcagaccc      660

tgttccaacc ctgtaacttg atgggagcta tgcagctgat tgaagacttc agcacacatg      720

tcagcattga ctgcagccct cataaaactg tcaagaagac tgtttgttag ctttaggact      780

gaagcatttt gaagggactg agtttcttaa ccctctaatc agcaagtacc ttctaacctg      840

caagactgcc cgccaactga cagtgagaat caagaacctc aacatgaaca gagctcctga      900

caacatcatt aaattttata agaagaccaa acagctgcca gtcctaggaa aatgctgtga      960

agagatccag ccacatcagt ggaagccacc tatagagaga gaagaacacc ggctcccatt     1020

ctggttaaag gccagtctgc catccatcca ggaagaactg cggcacatgg ctgatggtgc     1080

tagagaggta ggaaatatga ctggaaccac tgagatcaac tcagatcaag gcctagaaaa     1140

agacaactca gagttgggga gtgaaactcg gtacccactg ctattgccta agggtgtagt     1200

cctgaaactg aagccagttg ccgaccgttt ccccaagaag gcttggagac agaagcgttc     1260

atcagtcctg aaacccctcc ttatccaacc cagcccctct ctccagccca gcttcaaccc     1320

tgggaaaaca ccagcccaat caactcattc agaagcccct ccgagcaaaa tggtgctccg     1380

gattcctcac ccaatacagc cagccactgt tttacagaca gttccaggtg tccctccact     1440

gggggtcagt ggaggtgaga gttttgagtc tcctgcagca ctgcctgcta tgccccctga     1500

ggccaggaca agcttccctc tgtctgagtc ccagactttg ctctcttctg cccctgtgcc     1560

caaggtaatg atgccctccc ctgcctcttc catgtttcga aagccatatg tgagacggag     1620

accctcaaaa agaaggggag ccagggcctt tcgctgtatc aaacctgccc ctgttatcca     1680

ccctgcatct gttatcttca ctgttcctgc taccactgtg aagattgtga gccttggcgg     1740

tggctgtaac atgatccagc ctgtcaatgc ggctgtggcc cagagtcccc agactattcc     1800

catcgccacc ctcttggtta accctacttc cttcccctgt ccattgaacc agccccttgt     1860

ggcctcctct gtctcaccct taattgtttc tggcaattct gtgaatcttc ctataccatc     1920

cacccctgaa gataaggccc acatgaatgt ggacattgct tgtgctgtgg ctgatgggga     1980

aaatgccttt cagggcctag aacccaaatt agagccccag gaactatctc ctctctctgc     2040

tactgttttc cccaaagtgg aacatagccc agggcctcca ccagtcgata aacagtgcca     2100

agaaggattg tcagagaaca gtgcctatcg ctggaccgtt gtgaaaacag aggagggaag     2160

gcaagctctg gagccgctcc ctcagggcat ccaggagtct ctaaacaact cttcccctgg     2220

ggatttagag gaagttgtca agatggaacc tgaagatgct acagaggaaa tcagtggatt     2280

tctttgagct aggagaataa gagtctggag actgggagcc ttcacttcgg cctccgattg     2340

gtggcgcata gggtgtaacc aataggaaac ccctaaaggg tacttaaacc ccagattttg     2400

caactggggc tcttgagcag cttgctttag cctgctccca ctctgtggaa tatacttttg     2460

cttcaataaa tctgtgcttt tattgcttca ttgtttca                             2498


<210> 1346
<211> 2195
<212> DNA
<213> Homo sapiens

<400> 1346
gcggtgcccg gggcatctcc gcggcggaac tcagggaagg agctagctgg ggcgggggtg       60

atgatccagg ctgggttcca gcatagggct cttggtgggc acgctggggt cgggtggaat      120

gcaggagaga gaggaggtgg gacaggtggg tacctgggct ggaggcaggg cctgaggtgg      180

gcaggtgcag agggctgcac ttctcggctg aagccgggaa tgaggacccc gctctcgggt      240

gggattggag gggacccgcg gctgaggcgc tgggctgcga cagggacatc accgttctcc      300

tcctcaggga gatggtgctc gtcgtgcacg gcttcccgtc ctccgtggcc gcccttcggt      360

ttgagtgggc ttggcagcac ccgcacgcct cgcgccgcct ggcgcacgtg gggcctcgcc      420

tgcgaggaga gacagccttc gctttccacc tgcgcgtgct ggcgcacatg ctgcgcgcac      480

cgccctgggc tcgcctcccg ctcacgctgc gctgggtgcg cccagacctc cgccaggacc      540

tctgcctccc gccgccgccg cacgtgcctc tggccttcgg gcctccaccg ccccaggccc      600

cggccccaag gcgccgcgca ggtccctttg atgacgcgga gcctgagcca gaccaggggg      660

atccaggggc ctgctgctcc ctgtgcgccc agaccatcca ggatgaagag gggcccttgt      720

gttgccccca ccctggctgc ctgctaaggg cccatgtgat ctgcctggca gaggagtttc      780

ttcaggaaga accagggcag cttctgcccc tagagggcca atgcccttgc tgtgagaagt      840

cactgctttg gggagacctg atctggctgt gccagatgga cactgagaaa gaagtagaag      900

actcagaatt agaagaggaa catggagctg atccaggaca cctcccgccc gccactggag      960

tacgtgaagg gggtcccgct catcaagtac tttgcagagg cactggggcc cctgcagagc     1020

ttccaagccc gacctgatga cctgctcatc aacacctacc ccaagtctgg caccacctgg     1080

gtgagccaga tactggacat gatctaccag ggcggcgacc tagagaagtg taaccgggct     1140

cccatctacg tacgggtgcc cttccttgag gtcaatgatc caggggaacc ctcagggctg     1200

gagactctga aagacacacc gcccccacgg ctcatcaagt cacacctgcc cctggctctg     1260

ctccctcaga ctctgttgga tcagaaggtc aaggtggtct atgttgcccg aaacccaaag     1320

gacgtggcgg tctcctacta ccatttccac cgtatggaaa aggcgcaccc tgagcctggg     1380

acctgggaca gcttcctgga aaagttcatg gctggagaag tgtcctacgg gtcctggtac     1440

cagcacgtgc aggagtggtg ggagctgagc cgcacccacc ctgttctcta cctcttctat     1500

gaagacatga aggagaaccc caaaagggag attcaaaaga tcctggagtt tgtggggcgc     1560

tccctgccag aggagaccat ggacttcatg gttcagcaca cgtcgttcaa ggagatgaag     1620

aagaacccta tgaccaacta caccaccgtc ccccaggagc tcatggacca cagcatctcc     1680

cccttcatga ggaaaggcat ggctggggac tggaagacca ccttcaccgt ggcgcagaat     1740

gagcgcttcg atgcggacta tgcggagaag atggcaggct gcagcctcag cttccgctct     1800

gagctgtgag aggggctcct ggagtcactg cagagggagt gtgcgaatct accctgacca     1860

atgggctcaa gaataaagta tgatttttga gtcaggcaca gtggctcatg tctgcaatcc     1920

cagcgatttg ggaggttgag ctggtaggat cacaataggc cacgaatttg agaccagcct     1980

ggtaaaatag tgagacctca tctctacaaa gatgtaaaaa aattagccac atgtgctggc     2040

acttacctgt agtcccagct acttgggaag cagaggctgg aggatcattt cagcccagga     2100

ggttgtggat acagtgagtt atgacatgcc cattcactac agcctggatg acaagcaaga     2160

ccctccctcc aaagaaaata aagctcaatt aaaat                                2195


<210> 1347
<211> 2293
<212> DNA
<213> Homo sapiens

<400> 1347
ttccccactc ccccgccctc cccagggccc tgggaagggg ctcagcgtgg gaaaggatgg       60

ttgagtttta accagaggca aagcgtgagc gggatcagtg tgtgcggaac gcaagcagcc      120

gagagcggag aggcgccgct gtagttaact cctccctgcc cgccgcgccg accctcccca      180

ggaaccccca gggagccagc atgaagcgag ctcaccccga gtacagctcc tcggacagcg      240

agctggacga gaccatcgag gtggagaagg agagtgcgga cgagaatgga aacttgagtt      300

cggctctagg ttccatgtcc ccaactacat cttcccagat tttggccaga aaaagacgga      360

gaggaataat tgagaagcgc cgacgagacc ggatcaataa cagtttgtct gagctgagaa      420

ggctggtacc cagtgctttt gagaagcagg gatctgctaa gctagaaaaa gccgagatcc      480

tgcagatgac cgtggatcac ctgaaaatgc tgcatacggc aggagggaaa ggttactttg      540

acgcgcacgc ccttgctatg gactatcgga gtttgggatt tcgggaatgc ctggcagaag      600

ttgcgcgtta tctgagcatc attgaaggac tagatgcctc tgacccgctt cgagttcgac      660

tggtttcgca tctcaacaac tacgcttccc agcgggaagc cgcgagcggc gcccacgcgg      720

gcctcggaca cattccctgg gggaccgtct tcggacatca cccgcacatc gcgcacccgc      780

tgttgctgcc ccagaacggc cacgggaacg cgggcaccac ggcctcaccc acggaaccgc      840

accaccaggg caggctgggc tcggcacatc cggaggcgcc tgctttgcga gcgcccccta      900

gcggcagcct cggaccggtg ctccctgtgg tcacctccgc ctccaaactg tcgccgcctc      960

tgctctcctc agtggcctcc ctgtcggcct tccccttctc tttcggctcc ttccacttac     1020

tgtctcccaa tgcactgagc ccttcagcac ccacgcaggc tgcaaacctt ggcaagccct     1080

atagaccttg ggggacggag atcggagctt tttaaagaac tgatgtagaa tgagggaggg     1140

gaaagtttaa aatcccagct gggctggact gttgccaaca tcaccttaaa gtcgtcagta     1200

aaagtaaaaa ggaaaaaggt acactttcag ataatttttt ttttaaagac taaaggtttg     1260

ttggtttact tttatctttt ttaatgtttt tttcatcatg tcatgtatta gcagttttta     1320

aaaactagtt gttaaatttt gttcaagaca ttaaattgaa atagtgagta taagccaaca     1380

ctttgtgata ggtttgtact gtgcctaatt tactttgtaa accagaatga ttccgttttt     1440

gcctcaaaat ttggggaatc ttaacattta gtatttttgg tctgtttttc tccttgtata     1500

gttatggtct gtttttagaa ttaattttcc aaaccactat gcttaatgtt aacatgattc     1560

tgtttgttaa tattttgaca gattaaggtg ttgtataaat aatattcttt tggggggagg     1620

ggaactatat tgaattttat atttctgagc aaagcgttga caaatcagat gatcagcttt     1680

atccaagaaa gaagactagt aaattgtctg cctcctatag cagaaaggtg aatgtacaaa     1740

ctgttggtgg ccctgaatcc atctgaccag ctgctggtat ctgccaggac tggcagttct     1800

gatttagtta ggagagagcc gctgataggt taggtctcat ttggagtgtt ggtggaaagg     1860

aaactgaagg taattgaata gaatacgcct gcatttacca gccccagcaa cacaaagaat     1920

ttttaatcac acggatctca aattcacaaa tgttaacatg gataagtgat catggtgtgc     1980

gagtggtcaa ttgagtagta cagtggaaac tgttaaatgc ataacctaat tttcctggga     2040

ctgccatatt ttcttttaac tggaaatttt tatgtgagtt ttccttttgg tgcatggaac     2100

tgtggttgcc aaggtattta aaagggcttt cctgcctcct tctctttgat ttatttaatt     2160

tgatttgggc tataaaatat catttttcag gtttattctt ttagcaggtg tagttaaacg     2220

acctccactg aactgggttt gacctctgtt gtactgatgt gttgtgacta aataaaaaag     2280

aaagaacaaa gta                                                        2293


<210> 1348
<211> 3391
<212> DNA
<213> Homo sapiens

<400> 1348
ctgcctttct cggaacggaa cggagcagag tcgtgcgtgg ttgagtttag ataaaagccg       60

agtgagcgcg ctctgttcct taagattagt ttaaggtgcc ttggattgct ctgaagagct      120

ttgaccacct gatattgctt acatctggaa cttcttggct tctcattccc cagatgtgcg      180

ggtcagagag gattctacag gcaggaaaca tcttagaaat cagggttggg caggcaggag      240

ccaggagagt agctacaatg acttcaccag tactggtgga catacgagaa gaggtgacct      300

gccctatctg cctggagctc ctaacagaac ccctgagcat agactgtggc cacagcttct      360

gccaagcctg catcacacca aatggcaggg aatcagtgat tggtcaagaa ggggaaagaa      420

gctgccctgt gtgccagacc agctaccagc cagggaacct gcggcctaat cggcatctgg      480

ccaacatagt gaggcggctc agagaggtag tgttgggccc tgggaagcag ctgaaagcag      540

ttctttgtgc agaccatgga gaaaaactgc agctcttctg tcaggaggat gggaaggtca      600

tttgctggct ttgtgagcgg tctcaggagc accgtggtca ccacacgttc ctcgtggagg      660

aggttgccca ggagtaccag gagaagtttc aggagtctct aaagaagctg aagaacgagg      720

agcaggaagc tgagaagcta acagctttta tcagagagaa gaaaacatcc tggaagaatc      780

agatggagcc tgagagatgc aggatccaga cagagtttaa tcagctgcga aatatcctag      840

acagagtgga gcaacgggag ctgaaaaagc tggaacagga agagaagaag gggctacgaa      900

ttatagaaga ggctgagaat gatctggtcc accagaccca gtcgctgcga gagctcatct      960

cggatctgga gcgtcgatgt caggggtcaa caatggagct gctgcaggat gtgagtgatg     1020

tcacagaaag gagtgagttc tggaccctga ggaagccaga agctctccct acaaagctga     1080

gaagtatgtt ccgagcccca gatctgaaaa ggatgctgcg agtgtgtaga gagctgacag     1140

atgtccaaag ctactgggcc atccaggggt ctttaaccag aagagagagg agagcctcag     1200

gagttaggac cagaagaagc cagggaagca gtgcaatggc ttcaaaaatc ttgcttaacg     1260

tacaagagga ggtgacctgt cccatctgcc tggagctgtt gacagaaccc ttgagtctag     1320

actgtggcca cagcctctgc cgagcctgca tcactgtgag caacaaggag gcagtgacca     1380

gcatgggagg aaaaagcagc tgtcctgtgt gtggtatcag ttactcattt gaacatctac     1440

aggctaatca gcatctggcc aacatagtgg agagactcaa ggaggtcaag ttgagcccag     1500

acaatgggaa gaagagagat ctctgtgatc atcatggaga gaaactccta ctcttctgta     1560

aggaggatag gaaagtcatt tgctggcttt gtgagcggtc tcaggagcac cgtggtcacc     1620

acacagtcct cacggaggaa gtattcaagg aatgtcagga gaaactccag gcagtcctca     1680

agaggctgaa gaaggaagag gaggaagctg agaagctgga agctgacatc agagaagaga     1740

aaacttcctg gaagtatcag gtacaaactg agagacaaag gatacaaaca gaatttgatc     1800

agcttagaag catcctaaat aatgaggagc agagagagct gcaaagattg gaagaagaag     1860

aaaagaagac gctggataag tttgcagagg ctgaggatga gctagttcag cagaagcagt     1920

tggtgagaga gctcatctca gatgtggagt gtcggagtca gtggtcaaca atggagctgc     1980

tgcaggacat gagtggaatc atgaaatgga gtgagatctg gaggctgaaa aagccaaaaa     2040

tggtttccaa gaaactgaag actgtattcc atgctccaga tctgagtagg atgctgcaaa     2100

tgtttagaga actgacagct gtccggtgct actgggtgga tgtcacactg aattcagtca     2160

acctaaattt gaatcttgtc ctttcagaag atcagagaca agtgatatct gtgccaattt     2220

ggccttttca gtgttataat tatggtgtct tgggatccca atatttctcc tctgggaaac     2280

attactggga agtggacgtg tccaagaaaa ctgcctggat cctgggggta tactgtagaa     2340

catattcccg ccatatgaag tatgttgtta gaagatgtgc aaatcgtcaa aatctttaca     2400

ccaaatacag acctctattt ggctactggg ttatagggtt acagaataaa tgtaagtatg     2460

gtgtctttga agagtctttg tcctctgatc ccgaggtttt gactctctcc atggctgtgc     2520

ctccctgccg tgttggggtt ttcctcgact atgaagcagg cattgtctca tttttcaatg     2580

tcacaagcca tggctccctc atttacaagt tctctaaatg ttgcttttct cagcctgttt     2640

atccatattt caatccttgg aactgtccag ctcccatgac tctatgccca ccaagctctt     2700

gaattttctc atttcttcac ctacaaccct ttgtcttgac ttatctcctg caactgactc     2760

atctgcaaca ttcacaccat tgcttccttg tggtttccct tctttagaac ttttactcat     2820

ccttgagatg tatggtgtat ttggcttgag ttatgagaga tgcttattta ttcatttact     2880

ctttttcata ttttcagaga aagttaccta atccctccta aagacacagc agtatgggta     2940

taacatcctt gccttcccat ttatccatgt ttcactttat cactgatatg aagaggccca     3000

aagcctgtta gccaccatcc atgctaccta ggtagtccat aggaaccacc cccatgacca     3060

ccaccaacat caactaaagg ttcttggagg gtatgtcagt gtgttgctca ggatacccca     3120

ggtacatcaa ggaatcaagg agaggaaaat atgagcaata tgtgtattca gagtgaagat     3180

tttatgtcca gagtatttga gctcaaacct tgcctgttgt tttctaatca tgatgaatac     3240

tttctcagtt tctttttcct gaaatataaa ttgggattta agactgtacc taactattaa     3300

gatcactgtg taaaactaag tgtctctaaa tgtaatgcat cgatttagtg tctggaacat     3360

aataaatatt tgctctcatg attgctaaaa a                                    3391


<210> 1349
<211> 5787
<212> DNA
<213> Homo sapiens

<400> 1349
aaaagggcgg tggggcgggg ggcggggcag ggagagggag agaaatccag cagacatcta       60

gctctgcctt tctttcccag ccacagccag ggtagggctg ataaggcgct gatgcgttga      120

tggcagcctt gcagagctag acctgcactt aacttgcagc tgcctcccga gcctccaaga      180

tgtccacgcc ctgggtgaca ggcggcaggg cgctgccccg tgctcccccg gctctgctcg      240

acagcagcac gcagtgagag cctcgccgcc gccgaggagc aactcatgta acggcacagc      300

caacaagatg aacggagctt tggatcactc agaccaacca gacccagatg ccattaagat      360

gtttgtcgga cagatccccc ggtcatggtc ggaaaaggag ctgaaagaac tttttgagcc      420

ttacggagcc gtctaccaga tcaacgtcct ccgggaccgg agtcagaacc ctccgcagag      480

taaaggttgt tgtttcgtaa cattttatac aagaaaagct gcacttgagg cccagaatgc      540

actgcacaat attaaaactt tacctgggat gcatcatccc attcagatga aacctgcaga      600

tagtgaaaag tccaacgctg tggaagacag aaaattgttc ataggaatgg tatcgaagaa      660

atgtaatgag aacgacatca gggtgatgtt ctctccattt ggccagatag aagaatgccg      720

gatcctccgg ggacctgatg ggctgagtcg aggctgtgcg tttgtcacat tttctacaag      780

ggcaatggca cagaatgcaa tcaaagccat gcatcagtct cagaccatgg agggctgctc      840

ttcacctatc gtggtgaagt ttgctgacac tcagaaggac aaagagcaaa ggcgcctcca      900

gcagcagctc gctcagcaga tgcagcagct caacactgcc acctggggga acctgacagg      960

gctgggcgga ctgaccccac agtatctggc gctcctgcag caggccacct cctccagcaa     1020

cctgggtgcg ttcagcggca ttcaacaaat ggcaggcatg aatgctttac agttgcagaa     1080

cctggcgacg ctggctgctg ctgcagctgc ggcccagacc tcagccacca gcaccaatgc     1140

aaaccctctc tctaccacga gcagcgccct gggagccctc acgagtcccg tggctgcttc     1200

aacccccaac tccactgctg gtgcagccat gaactccttg acctctctcg ggactctgca     1260

aggactggct ggagccactg ttggactgaa taatattaat gcactagcag ctcccagaag     1320

caaaaggctt ttacttccaa aagataacaa cggtatggcg gctctgaatg gaggacttgg     1380

cgccacaggc ttgacgaatg gcacggctgg caccatggac gccctcaccc aggcctactc     1440

aggaattcaa cagtacgcag ccgccgcgct gcccactctg tacagccaga gcctgctgca     1500

gcagcagagc gctgcaggca gccagaagga aggtccagag ggggcaaacc tctttattta     1560

ccaccttcca caggaatttg gagaccagga cattctgcag atgttcatgc cttttggaaa     1620

tgttatctct gctaaagtct tcattgacaa acagaccaat ctgagcaagt gctttggttt     1680

tgttagctac gacaatccag tctctgcaca agctgctatc caagctatga atggctttca     1740

gatcggcatg aaacgcttga aggtgcagct gaagcgttcc aaaaacgaca gcaaacctta     1800

ctgatcctaa ccccagaggc tccctgctct cattttagct ttcttaggac atcttcatgc     1860

ccgttagttc atcgtttgcc tagcatgtcc ctgtggcgtc tcaaaaaaaa gtttcatcgt     1920

cccgtcattg tttctgatgt ctttctgacc tcacatcata tttggttctc ctactgacct     1980

ttgatctagt ttgacctttg aaatttgcat gtgacctcat ctagctatga attctgggaa     2040

gtcaatgtga aaaacattgc tgcattcatg caagactgaa atttattatt agacaaattc     2100

attatagaaa aaacctgtgg caaaaacgtt tctttcttat tttttttctt ttcctaaaac     2160

agacttgaaa gtattataca gggattggca ttcttcccgg tcactggtaa caatagcaat     2220

atgtgtccag ggacacagaa tgttggtttc taacagacta cttccaaaaa cagtttgaga     2280

aaaaaactgt ctgattttaa gtctctagag gtctgtaata gtttttacat ttttcaggca     2340

gtgtaaagtt ttttgataag gccattttag gtggctcact ttctcattaa gatatatata     2400

tagaaccact ttttgtagat tagtataaga aaaatattta ccctgttttg gggcaaatgc     2460

tacctatttg tgtcaccttt tgctgaactc acagttagac aatccatggt ttaatgcaca     2520

tgaaattacc tatattttat actgtttcaa tgtacaggag aaaggttact gtaaactgtg     2580

ttatgttggt gcttctgtga attaagttgt ggtttcatca tgagtcttaa tgttctttgt     2640

tgataagaca agtttagaat tggtttactt aatacaaaaa aaaaaaaaag aatttcaaaa     2700

aaaaaagttg tttgcttaaa aaaaatttca tgtgagggaa aaaaaaaaaa cctattccag     2760

aataagtttt gtgttggctt gtgaagcatt gatgtcattt tttttaattg tggactattt     2820

agatgtgttt gtgttcagca aaatgtgatg tttttttctt ttaaagaaaa aaagtgaaaa     2880

tatatagtgc caaattccaa aggtacttcc ttcctagagc ttcagtgtgt ttcttgtgag     2940

aagtaatttg ataacatggg tattttatta tgtgttttgt ataaatccct aatatttaaa     3000

aaaaaaaaca aaacaaaaaa aggttacaaa gtttgttaac ttgctatcct gtggtcttgt     3060

tgcctgaaat tgttattgtt tgttatttct ctctgatgtt ttttgtaaga cattgtataa     3120

gtgcccatgt cccacttttt taaccactcc gcacatcagt gctgtgaagg caacctcacc     3180

atgtattttc ttcataatct atggaaacct ctaaggtgag aaagttttga acttttaacc     3240

ctttctaccc agagctatct ggaatgttga tgacttttta tactgtcatg atttgagttt     3300

gttttggggt gtttccaatt tggatttttt tccctgcatc tatcctctaa gttgtttcgg     3360

tttgactact ttgttctttg gttaagatcc aaaagaaaac agaaaacaat tccacgaggc     3420

caatctaaag ggaaaaaatc ctacactact tttactactt ttgattattt ctcatttttg     3480

ggaaaagaat tcctaatgtg ctactagaat tccttcttca gttttaacga gtaattggat     3540

aaaccctgag ggaaaacgga ggtagattca gcacctaaca atcctgtatg cttttgagat     3600

cacgtttagt gctatgtcct agtctagaat attttcatat accttgcagt aaaacgactt     3660

tgtggcagga cagtctcttg aggggttttg tttctgtttc ctaaatactc ctaaataata     3720

tttctaatca gccattatgc tggggcatct ctgatcccag taggtacctc tgaatatacc     3780

aggtgtctgg agttagaagc ccatagccct ttcccagcct ttttggtttt tttaattgaa     3840

cacatttcat ctaagtaaag ctcagttctt tatcacaatt tactgaccaa atacctagca     3900

ccagttcctg ctgccacttt ttaaagtgcc atatgacttt ctacgaacag gtaccttgct     3960

gtcttgacaa atcctaatgt cacgcctaca gccccaacac aagctccagt cttcctcttc     4020

ggcatgccct ggaagcttct tccagtcttc ctcttcggca tgccctggaa gcttcttggc     4080

ctcagctccc cttccccgct cagcaccctg ttaggatcag tgtgtgtgga tgggatagcc     4140

ctgggatgga aaggactagc ctctactgat gcaaaaaaac aaaaagcaac acaaacgttt     4200

ccttcttata gcacatgcac ttccttacaa tgacatgatt tgtattatcc tcacatgtgt     4260

ttactactgc tggggccttc cttcatcctc tgagggctat tttgtacttt ctgcagcaat     4320

cagcttaata acaacactta ttgcacctgt ctctctctga gaacacggtg tgtctcgaca     4380

cgtaccacgt acgtggaaac acaagagccc accacttgaa tttctaagac catttcattc     4440

tgaaacttct tatcaattac ctaaatctca acgaaaaaca atttactgaa gccgactccc     4500

ctccccatct ccctctcaac ctcaacccac ctgcatgcat ctcccccaga ggaaacactg     4560

agggtagggg acaggaggct caggacgcgc cctctgaatc gagtgtttct tcttcacaag     4620

tcaccaagag aggacatgag ggggaaagtc ctttttgccc ttctccaaaa aataaccttc     4680

cacagagaca aactgtcctt ctatccactt ttatctttta ataaatatca aaaggaaaaa     4740

gctgcaaggg tgcaaagggc ctgtgccaga agaaaacaca cacagggaaa ccgctttttt     4800

taatcaattg tagagaatag tcatttttaa tctaaattag agaattgtga tacaatggca     4860

gtcctcaaag gcgtaacgag ttcatctttc tttcaccata ggggttatag ttggcttgtg     4920

ctactctgga atcattttac tgtttgtttt tattatctta agtgctaatt aaaaaaaaaa     4980

taaaatttta aaaaaacctg tagtttcatt acctttttga ataatgtcat acaaaaaatg     5040

tatttgtttt tttgtgctgt gagaattgat gtttgtagat taataatcat tttgtttaga     5100

attacaaaat agtttttaaa tattgtctga gaaaagccaa agttaatgca acctagtgga     5160

aactgtaaga ccatttgagt attgtttgtt ttattgatgc atttggattt tgttgtttga     5220

tggaatttga gccaaaaaaa aaatacgcag gctttcctat ttctacaact gattgtactt     5280

atgcattttg taccagtgga actttttata ctggagatta aaaaaaaaat ggaaattttt     5340

gtggcttgct ctggtgggcc cctgacaatg actgatttca agtttgattt cgggttgatt     5400

gattgattga ttgatagaaa gaaagttgct tttcttttga gaattaaaaa ctttggcttg     5460

atttcttttt tccctttgct tatatctagc attagaattt tgtcttaaaa taacagcggt     5520

aagtttcact ttttattctg tattgtgcag ttacacaata aggtaattag atttagaagt     5580

actcagtcac tttaagtgga taaatgtatt agttaaaact ttagggtttg cttttttgct     5640

gtttagatca aagttttttc tgattcttct gtcctcattg tgaacataac cgtgtagttg     5700

aaacagtcaa acttattttt gtaatgtatg ttattgtgtg atgcagtttt ttgcttctgt     5760

ctccaatatt aaaccatttt cctaata                                         5787


<210> 1350
<211> 2981
<212> DNA
<213> Homo sapiens

<400> 1350
agtgtaatgc tagaagtcct agaagaaatt tggagtgtgc gtgcgcgccg agcgcaccgg       60

ccttgcccag gccccagcct ggccgatgac accgatgcca acagcaatgg ttcaagtggc      120

aatgagtcca acgggcatga gtctagaggc gcatctcagc ggagctcaca cagctcctcc      180

tcaggcaacg gcaaggactc agccctgctg gagaccactg agagcagcaa gagcacaaac      240

tctcagagcc catccccacc cagcagttcc attgcctaca gcctcctgag tgccagctca      300

gagcaggaca acccgtccac cagtggctgc agcagtgaac agtcagcccg ggcaaggact      360

cagaaggaac tcatgacagc acttcgagag ctcaagcttc gactgccgcc agagcgccgg      420

ggcaagggcc gctctgggac cctggccacg ctgcagtacg cactggcctg tgtcaagcag      480

gtgcaggcca accaggaata ctaccagcag tggagcctgg aggagggcga gccttgctcc      540

atggacatgt ccacctatac cctggaggag ctggagcaca tcacgtctga gtacacactt      600

cagaaccagg ataccttctc agtggctgtc tccttcctga cgggccgaat cgtctacatt      660

tcggagcagg cagccgtcct gctgcgttgc aagcgggacg tgttccgggg tacccgcttc      720

tctgagctcc tggctcccca ggatgtggga gtcttctatg gttccactgc tccatctcgc      780

ctgcccacct ggggcacagg ggcctcagca ggttcaggcc tcagggactt tacccaggag      840

aagtccgtct tctgccgtat cagaggaggt cctgaccggg atccagggcc tcggtaccag      900

ccattccgcc taaccccgta tgtgaccaag atccgggtct cagatggggc ccctgcacag      960

ccgtgctgcc tgctgattgc agagcgcatc cattcgggtt acgaagctcc ccggataccc     1020

cctgacaaga ggattttcac tacgcggcac acacccagct gcctcttcca ggatgtggat     1080

gaaagggctg cccccctgct gggctacctg ccccaggacc tcctgggggc cccagtgctc     1140

ctgttcctgc atcctgagga ccgacccctc atgctggcta tccacaagaa gattctgcag     1200

ttggcgggcc agccctttga ccactcccct atccgcttct gtgcccgcaa cggggagtat     1260

gtcaccatgg acaccagctg ggctggcttt gtgcacccct ggagccgcaa ggtagccttc     1320

gtgttgggcc gccacaaagt acgcacggcc cccctgaatg aggacgtgtt cactcccccg     1380

gcccccagcc cagctccctc cctggacact gatatccagg agctgtcaga gcagatccac     1440

cggctgctgc tgcagcccgt ccacagcccc agccccacgg gactctgtgg agtcggcgcc     1500

gtgacatccc caggccctct ccacagccct gggtcctcca gtgatagcaa cgggggtgat     1560

gcagaggggc ctgggcctcc tgcgccagtg actttccagc agatctgtaa ggatgtgcat     1620

ctggtgaagc accagggcca gcagcttttt attgagtctc gggcccggcc tcagtcccgg     1680

ccccgcctcc ctgctacagg cacgttcaag gccaaggccc ttccctgcca atccccagac     1740

ccagagctgg aggcgggttc tgctcccgtc caggccccac tagccttggt ccctgaggag     1800

gccgagagga aagaagcctc cagctgctcc taccagcaga tcaactgcct ggacagcatc     1860

ctcaggtacc tggagagctg caacctcccc agcaccacta agcgtaaatg tgcctcctcc     1920

tcctcctata ccacctcctc agcctctgac gacgacaggc agaggacagg tccagtctct     1980

gtggggacca agaaagatcc gccgtcagca gcgctgtctg gggagggggc caccccacgg     2040

aaggagccag tggtgggagg caccctgagc ccgctcgccc tggccaataa ggcggagagt     2100

gtggtgtccg tcaccagtca gtgtagcttc agctccacca tcgtccatgt gggagacaag     2160

aagcccccgg agtcggacat catcatgatg gaggacctgc ctggcctagc cccaggccca     2220

gcccccagcc cagcccccag ccccacagta gcccctgacc cagccccaga cgcctaccgt     2280

ccagtggggc tgaccaaggc cgtgctgtcc ctgcacacac agaaggaaga gcaagccttc     2340

ctcagccgct tccgagacct gggcaggctg cgtggactcg acagctcttc cacagctccc     2400

tcagcccttg gcgagcgagg tagccacctg gggcctcctg gagcctgccc tctgcccagt     2460

ctaggactgg attgttgggg ggtgggtctt aagggaggtg tttctgctcc agggacccag     2520

gctggtgttg cttccaccac taggccctgc ctagggacag gcccctcgct agcttctccc     2580

cactaggatg gggttccggg ctgcagccag aggagggcag cctgggggga tggcactggg     2640

atgggcaggc agaggtgctg tctccaggta agcgacttca ggcctagcct gggggcaggg     2700

gcaggaagta tgcccactta ggagtcagtt gtcactgatg aagagacatg catagattct     2760

gggccaactc tgggtggggt ctgggcttca agggcaggtg gaaggcagcc cctccaggtg     2820

cctgagggag atcccctgca ggcagacgca ggactcagga ctgggctttc cagccccact     2880

cttcactcca ttgcaagcta ggcagaatac ggcctcgatg ggcaggagga atgcctaggc     2940

tggcagtgcc cacaggagtt tggcggacca gagccatctg t                         2981


<210> 1351
<211> 2924
<212> DNA
<213> Homo sapiens

<400> 1351
ggttgcgcgg gagactatgg cgtcctcctc ggtcccacca gccacggtat cggcggcgac       60

agcaggcccc ggcccaggtt tcggcttcgc ctccaagacc aagaagaagc atttcgtgca      120

gcagaaggtg aaggtgttcc gggcggccga cccgctggtg ggtgtgttcc tgtggggcgt      180

agcccactcg atcaatgagc tcagccaggt gcctcccccg gtgatgctgc tgccagatga      240

ctttaaggcc agctccaaga tcaaggtcaa caatcacctt ttccacaggg aaaatctgcc      300

cagtcatttc aagttcaagg agtattgtcc ccaggtcttc aggaacctcc gtgatcgatt      360

tggcattgat gaccaagatt acttggtgtc ccttacccga aaccccccca gcgaaagtga      420

aggcagtgat ggtcgcttcc ttatctccta cgatcggact ctggtcatca aagaagtatc      480

cagtgaggac attgctgaca tgcatagcaa cctctccaac tatcaccagt acattgtgaa      540

gtgccatggc aacacgcttc tgccccagtt cctggggatg taccgagtca gtgtggacaa      600

cgaagacagc tacatgcttg tgatgcgcaa tatgtttagc caccgtcttc ctgtgcacag      660

gaagtatgac ctcaagggtt ccctagtgtc ccgggaagcc agcgataagg aaaaggttaa      720

agaattgccc acccttaagg atatggactt tctcaacaag aaccagaaag tatatattgg      780

tgaagaggag aagaaaatat ttctggagaa gctgaagaga gatgtggagt ttctagtgca      840

gctgaagatc atggactaca gccttctgct aggcatccac gacatcattc ggggctctga      900

accagaggag gaagcgcccg tgcgggagga tgagtcagag gtggatgggg actgcagcct      960

gactggacct cctgctcttg tgggctccta tggcacctcc ccagagggta tcggaggcta     1020

catccattcc catcggcccc tgggcccagg agagtttgag tccttcattg atgtctatgc     1080

catccggagt gctgaaggag ccccccagaa ggaggtctac ttcatgggcc tcattgatat     1140

ccttacacag tatgatgcta agaagaaagc agctcatgca gccaaaactg tcaagcatgg     1200

ggctggggca gagatctcta ctgtccatcc ggagcagtat gctaagcgat tcctggattt     1260

tattaccaac atctttgcct aagagactgc ctggttctct ctgatgttca aggtggtggg     1320

gttctgagac acttggggga attgtgggga tattctagcc accagttctc ttcttccttt     1380

gctaaattca ggctgcaggc tccttccatc cagataactc catcctgtcg agtaggctct     1440

ttctgaccct cagaaataca ttgtcctttt tcctctttgc ccatttttct tccctctctt     1500

cctccccatg agaagtctgc ttgtagtatt agaatgttat tgttgactct ctcccaagtg     1560

ccttgatctt tgtaatatct cctgttgttt ctatgatata ggagctaggg gaagggggtt     1620

gtttgccttc ttcaggacct gactggacag atggacctgg ctcaagcaac tactctggat     1680

gcactttgct gtgtgggatg aactaaaagt gtctgaattt tgctgataac tttataaaac     1740

tcactatggc atgcttccct cctggtgggc cctaggatgg atgacactca agatactaca     1800

gatgtgggtg caggcatgca cacacacgat ggaatatggc cattcctaca caggtggggt     1860

agagagtggg tcagcagcct ggcacctcac agaggtggga cctaagagga ctcatgatta     1920

tgcagagaat tggattgggt ctctgtcata gattgagtaa tctcttccct tacctcaatt     1980

ccatctccac ccatctctac atctgggcac agcaacccag agatggccaa aagcattcaa     2040

gcctggggga agatgtttga ctattgctgc tcttcaccag aacctcacac ctctcctggg     2100

actggaaccc ttcagtgggt gtgtggccag ttttggaggc tggaatgatg ggccagggtg     2160

taggattcat tctccatgta aagtttcctt tcatcctgcc tagccatccc caaggtttat     2220

ttccagaaga aaggaatatc tctacttgga tcaattctgg tcatttcaag aggatggagg     2280

cctcaagtgt gggaacttcc cctactccct ggatgtgtgt acctagcaca cttccttctc     2340

ccaccccttt ttccagttgg atttgttttt ctgttctctt ctgtcctgtc ttatactgca     2400

actgtgtctc ctaggggaca gatggccttc tttgtcatct tcactctcca cccccagaga     2460

ggagtcagag ccataactca atcactcagc ccctccaaag atagttgatg tgtgataatc     2520

tcataatgtt gagaaccctg atgagataca ttgtcttcct ctccctacaa tgcctctggg     2580

gccaaggcac ccattcttct tgctatcctc catccccctt gaggcttcca cttttttttt     2640

ttttagacat aaagctgggc atcagcaact ggcctgtggt gatgcaaagc tgctttgctc     2700

tgtatctggc tggactgatc tgtctcacaa gaagccatga ggccataggg agaagctccc     2760

tctccccttc atcttctgct ccaaaggtgg tagcaagagg agtacccagt taggggttgg     2820

agcccccata taacatcttc ctgtcagaag actgatggat ctttttcatt ccaaccatct     2880

ccctttcccc cgatgaatgc aataaaactc tgtgacacca gcaa                      2924


<210> 1352
<211> 2296
<212> DNA
<213> Homo sapiens

<400> 1352
ggaagttgag cggcggcaag aaataatggc ggcagctacg ggggatcctg gactctctaa       60

actgcagttt gcccctttta gtagtgcctt ggatgttggg ttttggcatg agttgaccca      120

gaagaagctg aacgagtatc ggctggatga agctcccaag gacattaagg gttattacta      180

caatggtgac tctgctgggc tgccagctcg cttaacattg gagttcagtg cttttgacat      240

gagtgctccc accccagccc gttgctgccc agctattgga acactgtata acaccaacac      300

actcgagtct ttcaagactg cagataagaa gctccttttg gaacaagcag caaatgagat      360

atgggaatcc ataaaatcag gcactgctct tgaaaaccct gtactcctca acaagttcct      420

cctcttgaca tttgcagatc taaagaagta ccacttctac tattggtttt gctatcctgc      480

cctctgtctt ccagagagtt tacctctcat tcaggggcca gtgggtttgg atcaaaggtt      540

ttcactaaaa cagattgaag cactagagtg tgcatatgat aatctttgtc aaacagaagg      600

agtcacagct cttccttact tcttaatcaa gtatgatgag aacatggtgc tggtttcctt      660

gcttaaacac tacagtgatt tcttccaagg tcaaaggacg aagataacaa ttggtgtata      720

tgatccctgt aacttagccc agtaccctgg atggcctttg aggaattttt tggtcctagc      780

agcccacaga tggagtagca gtttccagtc tgttgaagtt gtttgcttcc gtgaccgtac      840

catgcagggg gcgagagacg ttgcccacag catcatcttc gaagtgaagc ttccagaaat      900

ggcatttagc ccagattgtc ctaaagcagt tggatgggaa aagaaccaga aaggaggcat      960

gggaccaagg atggtgaacc tcagtgaatg tatggaccct aaaaggttag ctgagtcatc     1020

agtggatcta aatctcaaac tgatgtgttg gagattggtt cctactttag acttggacaa     1080

ggttgtgtct gtcaaatgtc tgctgcttgg agccggcacc ttgggttgca atgtagctag     1140

gacgttgatg ggttggggcg tgagacacat cacatttgtg gacaatgcca agatctccta     1200

ctccaatcct gtgaggcagc ctctctatga gtttgaagat tgcctagggg gtggtaagcc     1260

caaggctctg gcagcagcgg accggctcca gaaaatattc cccggtgtga atgccagagg     1320

attcaacatg agcataccta tgcctgggca tccagtgaac ttctccagtg tcactctgga     1380

gcaagcccgc agagatgtgg agcaactgga gcagctcatc gaaagccatg atgtcgtctt     1440

cctattgatg gacaccaggg agagccggtg gcttcctgcc gtcattgctg caagcaagag     1500

aaagctggtc atcaatgctg ctttgggatt tgacacattt gttgtcatga gacatggtct     1560

gaagaaacca aagcagcaag gagctgggga cttgtgtcca aaccaccctg tggcatctgc     1620

tgacctcctg ggctcatcgc tttttgccaa catccctggt tacaagcttg gctgctactt     1680

ctgcaatgat gtggtggccc caggagattc aaccagagac cggaccttgg accagcagtg     1740

cactgtgagt cgtccaggac tggccgtgat tgcaggagcc ctggccgtgg aattgatggt     1800

atctgttttg cagcatccag aagggggcta tgccattgcc agcagcagtg acgatcggat     1860

gaatgagcct ccaacctctc ttgggcttgt gcctcaccag gttcttgatc aatatgaacg     1920

agaaggattt aacttcctag ccaaggtgtt taattcttca cattccttct tagaagactt     1980

gactggtctt acattgctgc atcaagaaac ccaagctgct gagatctggg acatgagcga     2040

tgatgagacc atctgagatg gccccgctgt ggggctgact tctccccggc cgcctgctga     2100

ggagctctcc atcgccagag caggactgct gaccccaggc ctggtgattc tgggcccctc     2160

ctccataccc cgaggtctgg gattcccccc tctgctgccc aggagtggcc agtgttcggc     2220

gttgctcggg attcaagata ccaccagttc agagctaaat aataaccttg gccttggcct     2280

tgctattgac ctggga                                                     2296


<210> 1353
<211> 1484
<212> DNA
<213> Homo sapiens

<400> 1353
gagttccgta ttctagttct gtgtgatctg atctttacct tcccttcctt ggatccctgt       60

gcacctactg gagccaggtt actctgggtc ctggacctga ctgcctcatt ctggaggctt      120

ccagacagcc acagttagtg cccaaacctg agaggatggc ttcagatgga gcatctgcat      180

tgccgggacc ggatatgagc atgaaaccta gtgccgcccc gtctccatcc cctgcacttc      240

cctttctccc accaacttct gacccaccag accacccacc cagggagcca cctccacagc      300

ccatcatgcc ttcagtattc tctccagaca accctctgat gctctctgct ttccccagct      360

cactgttggt gacaggggat gggggccctt gcctcagtgg ggctggggct ggcaaggtca      420

ttgtcaaagt caagacagaa ggggggtcag ctgagccctc tcaaactcag aactttatcc      480

ttactcagac tgccctcaat tcgactgccc cgggcactcc ctgtggaggc cttgagggtc      540

ctgcacctcc atttgtgaca gcatctaatg tgaagaccat tctgccctct aaggctgttg      600

gtgtcagcca ggagggtcct ccaggccttc cgcctcagcc tccaccacca gttgctcaac      660

tggtccccat tgtgcccctg gaaaaagctt ggccagggcc acatgggaca accggggaag      720

gaggtcctgt ggccactcta tccaagcctt ccctaggtga ccgctccaaa atttccaagg      780

acgtttatga gaacttccgt cagtggcagc gttacaaagc cttggcccgg aggcacctat      840

cccagagtcc tgacacagaa gctgtgaagg agtatgttga catcatggaa tggctggtgg      900

ggactcactt ggccactggg gagtcagatg gaaaacaaga ggaagaaggg cagcagcagg      960

aggaggaagg gatgtatcca gatccaggtc tcctgagcta catcaatgag ctgtgttctc     1020

agaaggtctt tgtctccaag gtggaggctg tcattcaccc tcaatttctg gcagatctgc     1080

tgtccccaga aaaacagaga gatcccttgg ccttaattga ggagctagag caagaagaag     1140

gactcactct tgcccagctg gtccagaagc gactcatggc cttggaagag gaggaagatg     1200

cagaggcgcc tccaagtttc agtggcgctc agttggactc aagtccttct ggttctgttg     1260

aggatgaaga tggggatggg cggcttcggc cctcacctgg gcttcagggg gctgggggcg     1320

ccgcttgcct tggaaaggtt tcttcttcag gaaaacgggc aagagaagtg catggtgggc     1380

aggagcaagc cctagatagc cccagaggga tgcacaggga tgggaacact ctgccatccc     1440

ccagcagctg ggacctgccc accaatggag aatcccaatg ttga                      1484


<210> 1354
<211> 1382
<212> DNA
<213> Homo sapiens

<400> 1354
gctcaggccc cgccctcaga cgagcaccgc ccgccggctc ctcccgcggc tcgaatcgcc       60

gtctctctcc tccccgcccc gccgagttct agaattcgcc gcgcagctgc ttcagcccct      120

cagccccagc cggaccctcg ggtcctcatc caccctcgca ggcgcaggcc gtggctaccc      180

cgaagtcaac tgtggaggat ccttcctggc ttccttcagc tccatcctgc ccttggatct      240

aggtcacccg cttggaccca actatctgag gcccgaatgc cccgcagctc ccgctgctcc      300

ctcgcgttct gctgaccccc ctccgagtca ggacatcccc tttagacccc actttaggcc      360

ctttcagccc aactccaact agccccatct gccgcttccg cacgcaccaa aaaggagact      420

aactacccag ccccgtccag tcatgcaggt gcaggatgat ggagtcaacc tcatcccctt      480

tgccaagtgt tccagggtgg tcagccgatc tccaccccca aggttgcctt cccagagcct      540

cagacccatg ccccagcgtt atggagatgt cttctggaag aaccttaatc aaaggcccac      600

ccccacttgg ctggaggagc agcacattcc acccatgctg ctcccacccc ctgaaatgct      660

ttggagaaga aagaagagga ggccatgttt ggaaggaatg cagcagcagg gccttggggg      720

agtccccgcc cgggtgaggg ctgtcactta ccacctggag gacctaagaa ggcgtcagag      780

catcatcaac gaactgaaga aggcccagtg gggcagctct ggggctgcat ctgagccagt      840

ggtgcttggc gaagagggct gtggattccc cagcaccaat gaataccctg atctggaaga      900

ggagagagca acctatccac aggaagagga ccgttttctc actcctggca gggcccagct      960

gctttggtct ccctggagcc ccctggatca ggaggaggct tgtgcctcca ggcagctgca     1020

ctctctggcc tcgttcagca ctgtcacagc cagaaggaac ccccttcaca atccctgggg     1080

gatggagttg gcagcgtctg aagagtaagg agaaaccacc gatgccgaga ggctagtggt     1140

gccccaggga cccaagacta gttccgtcac tagagtcacc ctcattgctg acatgaaggc     1200

gtttcccctt ccttcgtctc tccaactgcc tttcccatcc tctgaactag gcattaacag     1260

cccccgtggg ctcccatctc aacccaccgc tctcacagga gcaccccaag tcctgttttc     1320

ctccaggccc cgctcctggc cttgtattct ctctgctctg ttattaaaaa gcaagcaagt     1380

gg                                                                    1382


<210> 1355
<211> 616
<212> DNA
<213> Homo sapiens

<400> 1355
agcggagctg agctcgggta ggccgcgcga ggtccctcct ctccgggcgt ccgtgcgcct       60

agctctgcgc tgggagcctc gcgccctttg acagcagtta gttgctgact cggatgcaga      120

gagtcggtaa caccttctcc aacgagagcc gggtggcatc ccggtgtccc agcgtgggcc      180

ttgctgaacg gaaccgggtg gccacaatgc cggtgcggct gctcagggac agtccagcgg      240

ctcaggagga caatgaccat gccagagacg gtttccaaat gaagctggat gcccacggct      300

tcgccccgga ggaactggtg gtgcaggtgg atggccaatg gctgatggtg accggacagc      360

agcaactgga cgtcagggac ccggaaaggg tcagttaccg catgtcacag aaggtgcacc      420

ggaaaatgct cccgtccaac ctgagtccta ccgccatgac ctgctgcctg accccctccg      480

ggcagctgtg ggtcagaggc cagtgtgtgg cgctggccct ccctgaagcc caaacaggac      540

cgtccccgag actcgggagc ctcggctcta aggcttccaa cctgacccgg taaacaaacg      600

acgcgatgtg cagcag                                                      616


<210> 1356
<211> 2674
<212> DNA
<213> Homo sapiens

<400> 1356
ctgctttgtc tgctgtcccc tctctgctgg agaacttagc ccagagctag tgaacgagcc       60

tctgccgcag acatggagaa actcagcgcg ctgcaggagc agaagggcga gctgcgcaag      120

cggctgtcct acaccacaca caagctcgag aagctcgaga ccgagttcga ctccacgcgc      180

cactacctgg agatcgagct gcggcgcgcg caggaggaac tggagaaggt cacggagaag      240

ctgcgcagga ttcagagcaa ctacatggca ctgcagagga tcaaccagga gctggaggac      300

aagctgtacc gcatgggcca gcactatgag gaggagaagc gtgcgctgag ccacgagatt      360

gttgccctca acagccatct gctagaagcc aaggtgacca tcgacaagct gtcagaggac      420

aacgagctct ataggaagga ctgcaatcta gcggcccagc tgctgcagtg cagccagacc      480

tacggcaggg tccacaaggt gtctgagctg ccctcggatt tccaggagcg cgtgagcctg      540

cacatggaga agcacggctg cagcctgcca tccccgctct gccacccggc ctacgccgac      600

agcgtcccca cctgcgtcat tgccaaggtg ctggagaagc cggaccccgc cagcctgtcc      660

tcccgcctgt ccgatgcctc cgcccgcgac ctggccttct gcgacggggt ggagaaacca      720

ggcccgcggc ccccctacaa gggagacatc tactgcagtg acacagccct ctactgcccg      780

gaggagcggc ggcgagaccg gcggcctagc gtggacgcgc ccgtgaccga cgtgggcttc      840

ctgcgggccc agaactccac tgacagcgcg gccgaggagg aggaggaggc cgaggcggcg      900

gccttcccgg cgggcttcca gcatgaggcc ttccccagct acgcaggctc actgcccacg      960

tccagctcct actccagctt cagcgccacg tcggaggaga aggagcacgc gcaggccagc     1020

acgctgaccg cgtcgcagca ggccatctac ctgaacagcc gcgacgagct cttcgaccgc     1080

aagccacccg ccaccaccta cgagggcagc cctcgctttg ccaaggccac ggccgcggtg     1140

gcggccccgc tggaggccga agtggcccca ggcttcgggc ggaccatgtc accgtacccg     1200

gccgagacct tccgcttccc ggcctctccg ggtccccagc aggccctgat gcccccaaac     1260

ctgtggagcc tgcgggccaa gccggggacc gcccggctcc ccggggagga catgaggggc     1320

cagtggcgtc ccctgagcgt ggaggacatc ggcgcctact cctaccccgt gagcgctgcc     1380

ggccgcgcct caccctgcag cttctctgaa cgctactacg gcggggccgg gggcagcccg     1440

ggcaagaagg ccgacggccg cgccagcccg ctctacgcca gctacaaggc cgacagcttc     1500

tccgaggggg acgacctctc ccagggccac ctggcagagc cctgcttcct gcgggcgggc     1560

ggcgacctga gcctcagtcc cggccgctcg gctgacccac tgcccggcta tgcacccagc     1620

gagggggggg acggggacag gctcggggtg cagctgtgtg ggaccgccag cagccctgag     1680

cccgagcagg gttccaggga ctccttggag ccgagctcca tggaggcctc cccggaaatg     1740

catcctgccg cccgcctcag cccccagcag gcctttccgc ggactggtgg ctcggggctg     1800

agccgcaagg acagcctcac caaggcccag ctctacggaa ccttgctcaa ctgagcgcct     1860

gcgtgcaggc ctggccgtgg ttcgctcccc gccagcccac gtgccccaga agggccggcc     1920

tcacctctcc ccagcccccg ctgttcccct gccccggcca acaacgagga gtctgttcct     1980

ccccgcacct cctctcctcc ccagccctgt aggcctgagg ggagggtccc ccacaccacg     2040

gtgtccaccc ggccccggcc cgtggaactc cacttagagc gtttttcacg cgtccttccc     2100

ccatgtgaga ggagcatccc cccttttata aagcgaaact atttttatag agaaaaaggg     2160

tctttcttaa cgcacttggc ctccagctcc ctggacggct gccttggcgt tttcaacaca     2220

aagctccttt attttttggg cgagggtgcg tggggcctgc cccttggaag ggaagggaag     2280

gacggtgtcc tgtggagacc agactctgca agtggggaga ccacccccgc aagccagtga     2340

caagggagcc ctgaagttgt gtccacgaag agggagctga aacaaattcg gggctatgaa     2400

gtgttttaaa aatccattct tcgcagtgtg gccaccacac cgccctgagc cctcccacgg     2460

cccatcgtcc cgggtgggcc gggatgatgc cccagtgcgg ccggtgctca tctccgcccc     2520

cgggtccgcc ccctgacacc gtcttactct acctcagaca tgaggaggcc ctccattcct     2580

ggtttctgta gcttgcattc ttgttgtctc tgatgcatgc cctgccagtt agtactgtat     2640

tttgcattca ttaataaaag acaccggtgg aaag                                 2674


<210> 1357
<211> 3280
<212> DNA
<213> Homo sapiens

<400> 1357
agccaagcgg cgggctggcg gcgggctccg acgtctgcgc caggacctgg ctggctgagc       60

ccggcgcagc agcagcagcc agggcagcgc ggcccctact ccctgtcagg tcgtagaggc      120

gagcagggac cagctggtcg ccggcccctc gggcaagatg gggaaccggg agatggagga      180

gctgatcccg ctggtgaacc gtctgcagga cgcgttttcg gcgctgggac agagctgcct      240

gctggagctg ccgcagatcg ccgtggtggg cggccagagc gccggcaaga gctcggtgct      300

cgagaacttc gtgggcaggg actttctccc tcgagggtcg ggcattgtaa caagacgacc      360

tcttgtgctg cagcttgtta cttctaaagc agaatatgcc gagtttctac attgcaaagg      420

aaagaaattt acagattttg atgaagttcg ccttgagatt gaagcagaaa cagatcgcgt      480

gactggaatg aataaaggca tttcctccat acccattaat ttacgagtct attccccaca      540

cgtgttaaat ctaaccctta ttgatctacc tggaataact aaagtgcctg tgggagatca      600

gccaccagat atcgagtatc agatcagaga aatgattatg cagttcatca cgagggagaa      660

ctgtctgatt ttagctgtta ctccagccaa cactgatctt gcaaactcag atgcgctgaa      720

gctagctaaa gaagttgatc ctcaaggtct gagaaccatt ggagttatca ccaaactgga      780

ccttatggat gaaggaacgg atgccaggga tgttctagag aacaaactgt tgcctcttcg      840

caggggttac gtgggggtgg taaacagaag ccagaaggac atagatggga agaaggacat      900

aaaggcagcc atgctggcag agaggaagtt tttcctttcc cacccggctt acagacatat      960

cgctgaccga atgggaaccc cacacctgca gaaggtcctt aatcagcaac ttaccaacca     1020

cattcgggat accctaccaa acttcaggaa caaactacag ggacagttgc tctccataga     1080

acatgaagta gaagcctaca aaaatttcaa accagaagac ccaacaagga agaccaaagc     1140

attgctgcag atggttcagc aatttgctgt ggactttgag aagagaattg aagggtcagg     1200

ggatcaagta gataccctgg aactctcagg tggtgctaaa atcaatcgta tttttcatga     1260

acgctttcct tttgagatag taaagatgga gttcaatgag aaagaattgc gaagagaaat     1320

aagctatgca atcaaaaaca tacatggtat caggacaggg ttgtttactc cagacatggc     1380

atttgaagcg atagtcaaga aacagattgt aaagttgaaa gggccttcct tgaagagtgt     1440

ggatctggta atacaagaat taatcaacac tgtgaagaag tgtaccaaaa aactggcaaa     1500

cttccccaga ctctgcgagg aaacggaaag gattgttgct aaccacattc gtgagcgaga     1560

agggaagaca aaggaccagg tattgctatt gattgacatt caagtctctt acatcaacac     1620

caaccatgaa gacttcattg gcttcgcaaa tgctcagcag aggagcagtc aggttcacaa     1680

gaaaaccaca gttggaaatc agggaaccaa tcttccgcct tcaaggcaaa ttgtgattcg     1740

caaggggtgg ctcaccatca gcaacattgg catcatgaaa ggcggctcga agggatactg     1800

gttcgtcctt actgcggaaa gcttgtcctg gtataaagat gatgaggaaa aagaaaagaa     1860

gtacatgctt cccttggaca acctgaaagt tcgggatgtg gaaaagagct ttatgtctag     1920

caagcacatc tttgcactct ttaatacaga gcaaaggaat gtatacaaag actatcgctt     1980

ccttgagctg gcatgtgatt cccaggagga tgtcgacagc tggaaggcat ctctactaag     2040

agctggggtc tatcctgaca aatctgtagc tgaaaatgat gagaatggac aagcagaaaa     2100

cttttccatg gacccacaat tggagaggca agtggagacc attcgcaacc tcgtagactc     2160

ctacatgtcc attatcaaca aatgtatccg agatctaatt ccaaaaacaa taatgcacct     2220

tatgatcaat aacgttaaag atttcataaa ttccgagctc ctagcacagt tgtattcttc     2280

agaggaccaa aataccctga tggaggaatc tgctgagcag gctcagcgcc gggatgagat     2340

gcttcgaatg tatcaagcac tgaaagaagc ccttgggata attggggaca tcagcacagc     2400

caccgtgtcc actccggcac cccctccagt ggatgactcc tggatacagc actctcgcag     2460

gtcacctcct ccaagcccca caacccaaag gaggccaaca ctaagtgctc ccctcgcaag     2520

gcccacatcc ggccgaggac cagctcctgc cattccctct cctggccccc actctggggc     2580

tcctccagtc ccattccgtc caggcccatt acctcctttc cccagcagca gtgactcctt     2640

cggagcccct ccacaagttc catctaggcc tacgagggcc ccgcccagtg tcccaagccg     2700

gagaccaccc ccatcaccaa ctcgtcccac tataatccgc ccactagaat cctccctgtt     2760

agactaaacg aagtgtctgg catggcaatt aatcactaat gaattatgcg aaagcaacat     2820

atttgataac cgttgcagta aatcatgagt agtcgcatgt gtggacatca gtaggcaagt     2880

aaccagtttt actaatgcat tcatcgctca tcttcattgc tcatggtatg tcaaaccttt     2940

ggggtttgac tcagaaactg ctaacctttt agaggcttta tatgttgtac tgaccaaggt     3000

aggtttgtat agcagcccta tactttgggg atcatttgcc taccatggca tatatttgaa     3060

attgctttgg acaagttttc taggctatct accaggtagc tcattaaacg taattcttca     3120

gatatgagat agtgggctta gacctaagcc atacatattt cttttcccac attctgttta     3180

ggatgacagt aattctgttg tctaccatta atgctactac ctactccata attgcctatt     3240

tagctcctct tttcttcctt tttatttcat aagactgcta                           3280


<210> 1358
<211> 3941
<212> DNA
<213> Homo sapiens

<400> 1358
attgcgtccc gctctacctc tgtggttctt tgggagcgac ccccgggaag cgtccaaagt       60

ggagttccca cacacgctgc gaacccacag ccggttttct ctgaactcgc gtccctgagt      120

ccgggaggtg gaggcggaga aaagggtgcg gagcgacccc acgcagggcc gccccccctc      180

ccaccagcgc gtcctgccgc gccggcagcc acaggctggc atagcggctg ccgacccgcc      240

ctcgttcctc caccccctga acgggactgc tgggcccgcc ccgccccgcc tgcaggtgaa      300

gcggccgcag ccgccgagta ggtgcgtggg gatgatctca ctcgcgcgct ccgcgccagg      360

aggaggagga gcgggagcgg atccaacttc cgggtagtgg agccgcaagc caccggcatc      420

ttgctttttc ttccccctcc tcctgtgtgc cccgcgccgc tccctctttc ccttttattc      480

ccggccccac ccgccaaaat gaacagctcg gacgaagaga agcagctgca gctcattacc      540

agtctgaagg agcaagcaat aggcgaatat gaagacctta gagcagagaa ccagaaaaca      600

aaggagaagt gtgacaaaat taggcaagaa cgagatgaag ccgttaaaaa actggaagaa      660

tttcagaaaa tttctcacat ggtcatagag gaagttaatt tcatgcagaa ccatcttgaa      720

atagagaaga cttgtcgaga aagtgctgaa gctttggcaa caaagctaaa taaagaaaat      780

aaaacgttga aaagaatcag catgttgtac atggccaagc tgggaccaga tgtaataact      840

gaagagataa acattgatga tgaagattcg actacagaca cagacggtgc cgccgagact      900

tgtgtctcag tacagtgtca gaagcaaatt aaagaacttc gagatcaaat tgtatctgtt      960

caggaggaaa agaagatttt agccattgag ctggaaaatc tcaagagcaa actcgtagaa     1020

gtaattgaag aagtaaataa agttaaacaa gaaaagactg ttttaaattc agaagttctt     1080

gaacagagaa aagtcttaga aaaatgcaat agagtgtcca tgttagctgt agaagagtat     1140

gaggagatgc aagtaaacct ggagctggag aaggaccttc gaaagaaagc agagtcattt     1200

gcacaagaga tgttcattga gcaaaacaag ctaaagagac aaagccacct tctgctgcag     1260

agctccatcc ctgatcagca gcttttgaaa gctttagacg aaaatgcaaa actcacccag     1320

caacttgaag aagagagaat tcagcatcaa caaaaggtca aagaattaga agagcaacta     1380

gaaaatgaaa cactccacaa agaaatacac aacctcaaac agcaactgga gcttctagag     1440

gaagataaaa aggaattgga attgaaatat cagaattctg aagagaaagc cagaaattta     1500

aagcactctg ttgatgaact ccagaaacga gtgaaccagt ctgagaattc agtacctcca     1560

ccacctcctc ctccaccacc acttccccct ccacctccca atcctatccg atccctcatg     1620

tccatgatcc ggaaacgatc ccaccccagt ggcagtggtg ctaagaaaga aaaggcaact     1680

caaccagaaa caactgaaga agtcacagat ctaaagaggc aagcagttga agagatgatg     1740

gatagaatta aaaagggagt tcatcttaga cccgttaatc agacagccag accgaagaca     1800

aagccagaat cttcgaaagg ctgcgaaagt gcagtggatg aactaaaagg aatactgggg     1860

acacttaaca aatccactag ttcaagaagc ttaaaatccc ttgaccctga aaacagtgaa     1920

actgagttag aaaggatttt gcgtcgcaga aaggtgacag cagaagcaga tagcagtagt     1980

ccaactggga tattagccac ctcagagtcc aaatccatgc cagtgttggg ttctgtatcc     2040

agtgtaacaa aaacagcctt gaacaagaaa actctggagg cagaattcaa cagcccgtcc     2100

cccccaacac ctgagccagg tgaagggccc cgtaaattgg aaggatgcac aagttccaag     2160

gttacgtttc agcctcccag tagcattgga tgcaggaaaa aatacattga cggtgaaaaa     2220

caagccgaac cagttgtagt tttagatcct gtttctacac atgaacccca aaccaaagac     2280

caggttgctg aaaaagatcc aactcaacac aaggaggatg aaggcgaaat tcaaccagaa     2340

aacaaagaag acagcattga aaacgtgaga gagacagaca gctccaactg ctgatccata     2400

aaccagaagc ctgacatgtt tggaagtcct tttcaataag cacatgatta gtgttgttat     2460

attggcaagg gctgtagaca ttctgctctg gtcactgtat tcagaataca ggttcttttc     2520

tggtgtcact tttgtaagta gcaactataa acataagtaa gctgtttagc aaaacacaca     2580

ttcctagtag gttttggttt tttgatcttt ataaagatga ggtttttttc ctagttactg     2640

tattaagtat gacttctttt agaaggttac aaaaaaattc agatgttgat acctttttag     2700

gaaatgtgca taccactcat caaatggaat gctgaaagtt tgaggtgctt gtatataatc     2760

ggataaacaa aactgatcaa cccaatgtga ttttaaaagc ccccaaagaa gcttctgttt     2820

tgggtctgat cctcttgatg gagaaactgc agcagcatgg aaattgttgg gtactgtggc     2880

atacaagtta ttttctacag tagactgaga taaactgaaa actcaggagc tggcatcaaa     2940

ctcgtagtcc catagtcagt gttaattaca cacattgtta actattggat gaaaaataca     3000

tgctattgat tgtgtccaaa gcctcccgag gacctccgtg gggatgctct ggtagcctga     3060

atacagaact gaggtgaaag tccaaacctt gaattttaca gtagtaagtt ggtaaaccat     3120

gtgctctgtg ctatgagtta attatgtttt cccaaatact aatgtggcac aagtaccata     3180

ttttatcaga gttcttatgt acagtatggt gaagataagt gacaagcaca catttttctt     3240

gcttcactgc tgttctatat tacacaggtt tgttgttgtt ttttttaaaa aagaaattaa     3300

gcagtagtta gtctctaaaa atacaatgtt tcaggctacc acagtgaata aatagaaatg     3360

taatcaggga ttaaaaaaaa aacttatgca gcttttcaaa gttgattgtt tcaaaattgg     3420

tgtttattta aaataagtgg taatgtactt gaatgcactt tttatgacaa tgattcagta     3480

atggtaattt tactattaaa gaaagtgaaa ggtttagttt tgttagcatg gctcagcatg     3540

tagctgtcag gtgtttttca cctaagggca aaagaaaatg atagtaataa ttgcagtagt     3600

tgtattgtat tgtatttttg cacgtgtggt aagcataggc ttgaagaggt gggtaggcag     3660

gtacatgtac ttcctaaatt tggagataat tatctttctg taagttcgtt atgcttgact     3720

gtttccatgt tctcccaata atgattttat agttacttat cactttactc atggagaatt     3780

aaaacgtaat gtttttcaac tgtatctttc tttaactgga taatactgct atatgatatg     3840

cttactacag actgcattaa ttcacgaaac gaattctgtt atgctgtaat ttgaactctc     3900

ctcaccacaa cttattaaaa aggcaccaat agtttcccat t                         3941


<210> 1359
<211> 3099
<212> DNA
<213> Homo sapiens

<400> 1359
tgcgtgcgtg tgtgtgtgcg cgcgtgtgtg tgtctccgag tccctgggag agtggaggct       60

cattcactga ttagatccag cgctgagagg cagcactgct ccttctctca cgccaactga      120

gtctcttgat ctgtacatgc aatcccaggc agctcgcgaa cacaaacccg gggccagccg      180

cctactgctg ctgctgctgc tgccgctgcc gccgccgccg ccgccgctgc ctccgccggc      240

tctgcgaacc cgggactttt catgcaccac actctccgcc tgcttccctc cgtgtcctga      300

aaagtgcgac cgttctccca aggaatttcc acggtcttag gagggaatga ttccccagta      360

atattccctg ccctgaccca aagtgctggt tggcctccct cccagggaag actgcttctt      420

gcgtaacgcc ggccacagaa agagactccg atggacttac accgggcagc cttcaagatg      480

gagaactcat cctaccttcc caaccctctg gcatccccag cactgatggt cctggcatcc      540

acggctgagg ccagccgtga tgcttccatc ccttgtcagc agccacgacc ctttggtgta      600

cctgtctcag ttgacaagga cgtgcatatt cctttcacca acggttccta tacctttgcc      660

tctatgtacc atcggcaagg tggggtgcca ggcacttttg ccaatcgtga tttcccccct      720

tctctactac acctccaccc tcaatttgct cccccaaatc tagattgcac cccaatcagt      780

atgctgaatc atagtggtgt gggggctttc cggccctttg cctccaccga ggaccgggag      840

agctatcagt cagcctttac gccggccaag cgacttaaga actgccatga cacagagtct      900

ccccacttgc gcttctcaga tgcagatggc aaggaatatg actttgggac acagctgcca      960

tctagctccc ccggttcact aaaggttgat gacactggga agaagatttt tgctgtctct     1020

ggcctcattt ctgatcggga agcctcatct agcccagagg atcggaatga cagatgtaag     1080

aagaaagcag cggcattgtt cgacagccag gccccaattt gccccatctg ccaggtcctg     1140

ctgaggccca gtgagctgca ggagcatatg gagcaggaac tggagcagct agcccaactg     1200

ccctcgagca agaattccct tctgaaggat gccatggctc caggcacccc aaagtccctc     1260

ctgttgtctg cttccatcaa gagggaagga gagtctccaa cggcatcacc ccactcatct     1320

gccaccgatg acctccacca ttcagacaga taccagacct ttctgcgagt acgagccaac     1380

cggcagaccc gactgaatgc tcggattggg aaaatgaaac ggaggaagca agatgaaggg     1440

cagagggaag gctcctgcat ggctgaggat gatgctgtgg acatcgagca tgagaacaac     1500

aaccgctttg aggagtatga gtggtgtgga cagaagcgga tacgggccac cactctcctg     1560

gaaggtggct tccgaggctc tggcttcatc atgtgcagcg gcaaagagaa cccggacagt     1620

gatgctgact tggatgtgga tggggatgac actctggagt atgggaagcc acaatacaca     1680

gaggctgatg tcatcccctg cacaggcgag gagcctggtg aagccaagga gagagaggca     1740

cttcggggcg cagtcctaaa tggcggccct cccagcacgc gcatcacacc tgagttctct     1800

aaatgggcca gtgatgagat gccatccacc agcaatggtg aaagcagcaa gcaggaggcc     1860

atgcagaaga cctgcaagaa cagcgacatc gagaaaatca ccgaagattc agctgtgacc     1920

acgtttgagg ctctgaaggc tcgggtcaga gaacttgaac ggcagctatc tcgtggggac     1980

cgttacaaat gcctcatctg catggactcg tactcgatgc ccctaacgtc catccagtgt     2040

tggcacgtgc actgcgagga gtgctggctg cggaccctgg gtgccaagaa gctctgccct     2100

cagtgcaaca cgatcacagc gcccggagac ctgcggagga tctacttgtg agctatctgc     2160

cccaggcagg cctcgcctcc agcagcccca cctgccccca gcctctgtga cagtgaccgt     2220

ctccctttgt acatacttgc acacaggttc cccatgtaca tacatgcaca tactcaaaca     2280

tgcgtacaca cacacacatt tacacacgca ggactctgga gccagagtag aggctgtggc     2340

ccaggcacta cctgctggct cccacctatg gtttgggggc catacctgtt ccagctctgt     2400

tcccagggtg gggcagggag gtgggggttg ggggagtagt ggggcacggc tcctaagatc     2460

cagcccccat actgacagac ggacagacag acatgcaaac accagactga agcacatgta     2520

atatagaccg tgtatgttta caatgttgtg tataaatggg acaactcctc gccctctacc     2580

tgtcccctcc ccctttggtt gtatgatttt cttctttttt aagaacccct ggaagcagcg     2640

cctccttcag ggttggctgg gagctcggcc catccacctc ttggggtacc tgcctctctc     2700

tctcctgtgg tgtcccttcc ctctcccatg tgctcggtgt tcagtggtgt atatttcttc     2760

tcccagacat ggggcacacg ccccaaggga catgatcctc tccttagtct tagctcatgg     2820

ggctctttat aaggagttgg ggggtagagg caggaaatgg gaaccgagct gaagcagagg     2880

ctgagttagg gggctagagg acagtgctcc tggccaccca gcctctgctg agaaccattc     2940

ctgggattag agctgccttt cccagggaaa aagtgtcgtc tccccgaccc tcccgtgggc     3000

cctgtggtgt gatgctgtgt ctgtatattc tatacaaagg tacttgtcct ttccctttgt     3060

aaactacatt tgacatggat taaaccagta taaacagtt                            3099


<210> 1360
<211> 2561
<212> DNA
<213> Homo sapiens

<400> 1360
tgtctgatga tgctggtgac accttagcca ctggagacaa agcagaagtt actgaaaacg       60

gagtccctga aagtgagtga aagcccaccc acttcccctt catcagcctc tcggggtatg      120

ctgtctgcca tcaccaatgt ggttcaaaac acaggtaaaa gtgtcttaac tggaggcctt      180

gatgcgttgg aattcatcgg caagaaaacc atgaatgtcc ttgcagaaag tgacccgggc      240

tttaagcgga ccaagacgct catggagaga actgtttcct tgtctcagat gttaagggaa      300

gctaaggaga aggagaagca gagactggca cagcagctca cgatggagag aaccgcgcac      360

tacgggatgc tgtttgatga atatcaaggc ttgtcacacc tggaagccct ggaaattctg      420

tccaatgaaa gcgaaagcaa ggttcagtca tttttagcat cacttgatgg agagaagctg      480

gaactcttaa aaaatgacct aatttccatt aaagacatct ttgcagccaa agaattagag      540

aatgaagaaa atcaagaaga acaaggctta gaagaaaagg gagaagaatt tgctcgcatg      600

cttacagagc ttctctttga attacatgtg gcggccacac ctgacaaact caataaggcc      660

atgaagaggg ctcatgactg ggtggaagag gatcaaaccg tggtgtcagt agatgtggca      720

aaagtgtccg aagaagaaac aaagaaggaa gaaaaggaag agaaatctca agaccctcaa      780

gaagacaaaa aggaggaaaa gaaaactaag accatagagg aagtatacat gtcgtccatt      840

gaaagtctgg cggaggtaac agcgcgctgt attgagcagc ttcataaagt agcagaatta      900

attcttcatg gacaagaaga ggaaaaacca gctcaggacc aagcaaaagt tctaataaaa      960

ttaactactg caatgtgcaa tgaagtggcc tctttatcaa agaagtttac gaattcttta     1020

accactgttg ggagcaacaa gaaggccgag gtccttaacc ccatgatcag tagtgtattg     1080

ttagagggct gcaacagtac aacgtacata caggatgcct tccagctgct gctgcctgtt     1140

ctgcaggtct cacatatcca gaccagttgt ttgaaagcac agccgtgacc tggccagact     1200

ccatctagtt aaaggagaca gctggccgcc ttgcctcaat atgtaccatt taaggggatg     1260

ttctctgtgc gcctggccac agacatccat ttgaggacac tacaagcaat tttgcacaga     1320

caatattgag aatgcaaatt tagagagagt tatcatttct ctcaatgtgt ataattgttt     1380

ttacaaacaa ttgtgttttc tttatgttaa tttaaactta cacagcttat attgaaaatt     1440

tcctttcatc tgaaatttat ttacaaatat tcgtgttcat tttcctggtt aagcatgcta     1500

tatttagaaa ctcatgggga gaccttagac ttttgtttaa tcctttatgt ttcaaccttt     1560

aaatgttcca ttcttatagt attactttaa atcaattcta aaactgaact ttgttttgtt     1620

acataaatgt cgcaggcaaa aataacacta cttatagatt ttacctatta tggtaaaaaa     1680

taggaacata ttgtcattct tttttttttt ttttttttga gacagagtct cactctgtcg     1740

ccaggctgga gtgcgttggc acaatctcgg ctcactgcaa cctccgcctc ctgggttcaa     1800

tcgattctcc tgcctcagcc tcctgagtag ctgggactac aggtgtgtgc caccacgccc     1860

agccaatttt ttttgtattt ttagtagaga cagggtttca ccatgttggc caggatggtc     1920

tcgatctcct gacctcgtga tctgcccgcc tcagcctccc aaagtgctgg gattacaggc     1980

ttgagccacc gcgcccggcc ggtcattcat tcttgcaaca agcatttatt gagcacctac     2040

tgtgtgctca cagtaaagaa acgtgatctt atcccagtag aggtagatat tctgaaaaag     2100

aataattctt aaactgctta aaacaggggt ccccaccccc aggccacaga ccagtaccag     2160

tccgtggcac tggttaggaa ccaggccaca cagcaggggg tgagcggtgg gtgagtgagc     2220

acagcttcat ctgtatttac agctgctccc cagagcttgc attactgcct gagctctgcc     2280

tcccgtcagg tcagcagcag cattagagtc tcatgggagt gcgaaccctg ttgtgaactg     2340

cacatgcgag ggatctaggt tgtgcactcc ttatgagaat ctaatgcctg atgaatctaa     2400

tgcctcatga tctgaggttg aatagcttcg tgccgaaacc atcccccacc cccatcccgc     2460

taccccgagt ccgtgaaaaa attgtcttcc atgaaaccgg tccctggtac cagaaaggtt     2520

ggggaccact ggcttaaaat accaataaat ttttgaacct t                         2561


<210> 1361
<211> 745
<212> DNA
<213> Homo sapiens

<400> 1361
atctcccatc aacatgtcct acaactgctg ctctggaaac ttctcctccc gctcctgtgg       60

tggctacctg cactacccag cctcctcctg tggcttttcc taccccagca accaggtcta      120

cagcactgac ctctgctctc ccagcacgtg ccagctgggt tcctctctct ataggggctg      180

tcagcagacc tgctgggagc ccaccagctg ccagacatcc tatgtggagt ccagcccctg      240

ccagacctcc tgctaccgtc ccagaacctc cttgctctgc agtccctgcc agacaactta      300

ctctgggtct ctaggctttg gatccagcag ctgccgctcc ctgggctatg gatcgaggag      360

ctgctactca gtgggctgtg ggtccagtgg cttcagatcc ctgggttatg gaggctgtgg      420

cttcccttcc ctgggctatg gcgttggatt ctgccgccca acctacttgg cttctaggag      480

ctgccagtct tcttgctaca gaccaacttg tggatcaggc ttctactatt gatcatcttg      540

ttaaattgct gattttgttg gctaatgcct tcaatgcctc tactcataac ctttattgtc      600

ttcatcatgt acagaaagaa ttagcctctt attctataat tatcaagttc tcagtttgtc      660

tttgtcccca aatactggct ggcaggcttc atctgaaaaa ctgtaattgg agaactagct      720

caaaataaat cttgaaatac acatt                                            745


<210> 1362
<211> 2663
<212> DNA
<213> Homo sapiens

<400> 1362
ggaggagaga agaggaggtg gagaaggctt gggctcgcgc cgctgaagtc ggcttacccg       60

ctggccgcct cctgacaagc gggagggatc cgcggtggac ccagggaagc ggaggagcct      120

ggcggccacc ccctcttcct cacttccctg tactctcatc gctctcggcc tccgacacga      180

aaaggaagca aatgagctga tggaagatct gtttgaaact ttccaagatg agatgggatt      240

ctccaacatg gaagatgatg gcccagaaga ggaggagcgt gtggctgagc ctcaagctaa      300

ctttaacacc cctcaagctc tacggtttga ggaactactg gccaacctac taaatgaaca      360

acatcagata gcgaaggaac tatttgaaca gctgaagatg aagaaacctt cagccaaaca      420

gcagaaggag gtagagaagg ttaaacccca gtgtaaggaa gttcatcaga ccctgattct      480

ggacccagca caaaggaaga gactccagca gcagatgcag cagcatgttc agctcttgac      540

acaaatccac cttcttgcca cctgcaaccc caatctcaat ccggaggcca gtagcaccag      600

gatatgtctt aaagagctgg gaacctttgc tcaaagctcc atcgcccttc accatcagta      660

caaccccaag tttcagaccc tgttccaacc ctgtaacttg atgggagcta tgcagctgat      720

tgaagacttc agcacacatg tcagcattga ctgcagccct cataaaactg tcaagaagac      780

tgccaatgaa tttccctgtt tgccaaagca agtggcttgg atcctggcca caagcaaggt      840

tttcatgtat ccagagttac ttccagtgtg ttccctgaag gcaaagaatc cccaggataa      900

gatcctcttc accaaggctg aggacaattt gttagcttta ggactgaagc attttgaagg      960

gactgagttt cttaaccctc taatcagcaa gtaccttcta acctgcaaga ctgcccgcca     1020

actgacagtg agaatcaaga acctcaacat gaacagagct cctgacaaca tcattaaatt     1080

ttataagaag accaaacagc tgccagtcct aggaaaatgc tgtgaagaga tccagccaca     1140

tcagtggaag ccacctatag agagagaaga acaccggctc ccattctggt taaaggccag     1200

tctgccatcc atccaggaag aactgcggca catggctgat ggtgctagag aggtaggaaa     1260

tatgactgga accactgaga tcaactcaga tcaaggccta gaaaaagaca actcagagtt     1320

ggggagtgaa actcggtacc cactgctatt gcctaagggt gtagtcctga aactgaagcc     1380

agttgccgac cgtttcccca agaaggcttg gagacagaag cgttcatcag tcctgaaacc     1440

cctccttatc caacccagcc cctctctcca gcccagcttc aaccctggga aaacaccagc     1500

ccaatcaact cattcagaag cccctccgag caaaatggtg ctccggattc ctcacccaat     1560

acagccagcc actgttttac agacagttcc aggtgtccct ccactggggg tcagtggagg     1620

tgagagtttt gagtctcctg cagcactgcc tgctatgccc cctgaggcca ggacaagctt     1680

ccctctgtct gagtcccaga ctttgctctc ttctgcccct gtgcccaagg taatgatgcc     1740

ctcccctgcc tcttccatgt ttcgaaagcc atatgtgaga cggagaccct caaaaagaag     1800

gggagccagg gcctttcgct gtatcaaacc tgcccctgtt atccaccctg catctgttat     1860

cttcactgtt cctgctacca ctgtgaagat tgtgagcctt ggcggtggct gtaacatgat     1920

ccagcctgtc aatgcggctg tggcccagag tccccagact attcccatcg ccaccctctt     1980

ggttaaccct acttccttcc cctgtccatt gaaccagccc cttgtggcct cctctgtctc     2040

acccttaatt gtttctggca attctgtgaa tcttcctata ccatccaccc ctgaagataa     2100

ggcccacatg aatgtggaca ttgcttgtgc tgtggctgat ggggaaaatg cctttcaggg     2160

cctagaaccc aaattagagc cccaggaact atctcctctc tctgctactg ttttccccaa     2220

agtggaacat agcccagggc ctccaccagt cgataaacag tgccaagaag gattgtcaga     2280

gaacagtgcc tatcgctgga ccgttgtgaa aacagaggag ggaaggcaag ctctggagcc     2340

gctccctcag ggcatccagg agtctctaaa caactcttcc cctggggatt tagaggaagt     2400

tgtcaagatg gaacctgaag atgctacaga ggaaatcagt ggatttcttt gagctaggag     2460

aataagagtc tggagactgg gagccttcac ttcggcctcc gattggtggc gcatagggtg     2520

taaccaatag gaaaccccta aagggtactt aaaccccaga ttttgcaact ggggctcttg     2580

agcagcttgc tttagcctgc tcccactctg tggaatatac ttttgcttca ataaatctgt     2640

gcttttattg cttcattgtt tca                                             2663


<210> 1363
<211> 2218
<212> DNA
<213> Homo sapiens

<400> 1363
caggctgggt tccagcatag ggctcttggt gggcacgctg gggtcgggtg gaatgcagga       60

gagagaggag gtgggacagg tgggtacctg ggctggaggc agggcctgag gtgggcaggt      120

gcagagggct gcacttctcg gctgaagccg ggaatgagga ccccgctctc gggtgggatt      180

ggaggggacc cgcggctgag gcgctgggct gcgacaggga catcaccgtt ctcctcctca      240

gggagatggt gctcgtcgtg cacggcttcc cgtcctccgt ggccgccctt cgggtaagga      300

aggagaccgg gcagcggcgg ccgggtgagg gcttgggttc cgcccctcgc tccgagccgc      360

cctgatgccc ctgtacgccg cccgcagttt gagtgggctt ggcagcaccc gcacgcctcg      420

cgccgcctgg cgcacgtggg gcctcgcctg cgaggagaga cagccttcgc tttccacctg      480

cgcgtgctgg cgcacatgct gcgcgcaccg ccctgggctc gcctcccgct cacgctgcgc      540

tgggtgcgcc cagacctccg ccaggacctc tgcctcccgc cgccgccgca cgtgcctctg      600

gccttcgggc ctccaccgcc ccaggccccg gccccaaggc gccgcgcagg tccctttgat      660

gacgcggagc ctgagccaga ccagggggat ccaggggcct gctgctccct gtgcgcccag      720

accatccagg atgaagaggg gcccttgtgt tgcccccacc ctggctgcct gctaagggcc      780

catgtgatct gcctggcaga ggagtttctt caggaagaac cagggcagct tctgccccta      840

gagggccaat gcccttgctg tgagaagtca ctgctttggg gagacctgat ctggctgtgc      900

cagatggaca ctgagaaaga agtagaagac tcagaattag aagaggaaca tggagctgat      960

ccaggacacc tcccgcccgc cactggagta cgtgaagggg gtcccgctca tcaagtactt     1020

tgcagaggca ctggggcccc tgcagagctt ccaagcccga cctgatgacc tgctcatcaa     1080

cacctacccc aagtctggca ccacctgggt gagccagata ctggacatga tctaccaggg     1140

cggcgaccta gagaagtgta accgggctcc catctacgta cgggtgccct tccttgaggt     1200

caatgatcca ggggaaccct cagggctgga gactctgaaa gacacaccgc ccccacggct     1260

catcaagtca cacctgcccc tggctctgct ccctcagact ctgttggatc agaaggtcaa     1320

ggtggtctat gttgcccgaa acccaaagga cgtggcggtc tcctactacc atttccaccg     1380

tatggaaaag gcgcaccctg agcctgggac ctgggacagc ttcctggaaa agttcatggc     1440

tggagaagtg tcctacgggt cctggtacca gcacgtgcag gagtggtggg agctgagccg     1500

cacccaccct gttctctacc tcttctatga agacatgaag gagaacccca aaagggagat     1560

tcaaaagatc ctggagtttg tggggcgctc cctgccagag gagaccatgg acttcatggt     1620

tcagcacacg tcgttcaagg agatgaagaa gaaccctatg accaactaca ccaccgtccc     1680

ccaggagctc atggaccaca gcatctcccc cttcatgagg aaaggcatgg ctggggactg     1740

gaagaccacc ttcaccgtgg cgcagaatga gcgcttcgat gcggactatg cggagaagat     1800

ggcaggctgc agcctcagct tccgctctga gctgtgagag gggctcctgg agtcactgca     1860

gagggagtgt gcgaatctac cctgaccaat gggctcaaga ataaagtatg atttttgagt     1920

caggcacagt ggctcatgtc tgcaatccca gcgatttggg aggttgagct ggtaggatca     1980

caataggcca cgaatttgag accagcctgg taaaatagtg agacctcatc tctacaaaga     2040

tgtaaaaaaa ttagccacat gtgctggcac ttacctgtag tcccagctac ttgggaagca     2100

gaggctggag gatcatttca gcccaggagg ttgtggatac agtgagttat gacatgccca     2160

ttcactacag cctggatgac aagcaagacc ctccctccaa agaaaataaa gctcaatt       2218


<210> 1364
<211> 1696
<212> DNA
<213> Homo sapiens

<400> 1364
cacagacctg gaacaaacta aagccagaca catactatgg acaccaaggg ctgtacaaca       60

accaattctc cttcaacccc atgtcaaaac tgctctagga ttacaaatgt tagtaccatc      120

tcttctaaca acggctgcca tcctggtggc cttacagtca acaactgtca accagctggc      180

cacgttctca gaattccctg ggaccagggc tgccaaccca ctcctcgctt ttgtcgcaag      240

cccatctacc taatgaacaa cttcaatgcc cgtttttctc tggatgactg cagctggtat      300

ggtgaaggca tcaacagtaa tgagaaggag accatgcaaa tcttgaacga gcgccttgct      360

aactacctgc aaaaggtgcg aatgctagaa cgagagaatg ctgaactgga atctaaaatc      420

caggaagaaa gtaacaaaga gctccctgtt ctatgtcctg attacctgtc ttactacact      480

accattgagg agctccagca gaagatcttg tgtaccaagg ccgagaattc cagactggtc      540

tcgcaaattg acaacaccaa actgactgca gatgacttga gagccaaata cgaagctgag      600

gtgtctctac gccagctggt agagtcagat gccaatggcc tcaagcagat cctgaatgtg      660

ctgaccctgg gcaaggccga cctagaggca caagtccagt ctctgaaaga ggagctcctt      720

tgcctcaaga acaaccacaa agaggaaatc aattctttac agtgtcagct tggggagaga      780

cttgacattg aagtgactgc tgccccttct gctgacctaa accaggttct acaagaaatg      840

agatgtcaat atgagcccat catggagaca aaccgcaaag atgtggaaca gtggttcaac      900

acgcagatag aggagctgaa tcaacaagtg gtgaccagct ctcaacagca gcaatgctgc      960

caaaaggaga tcatagaact gagacgcagt gtgaacactc tggaggttga actgcaggcc     1020

cagcatcgaa tgagagattc ccaagagtgc atcctaacgg agacagaggc tcgctacacg     1080

gccttgctga cccagatcca gagtctgatt gataacctgg aagctcagct ggcagagatc     1140

cggtgtgccc tggaaagaca gaaccaagaa tacgagatcc tgctggacgt caagtcccgg     1200

ctggaatgtg agattaccac ataccgcagc cttctggaga gctcggatgg caagcgtccc     1260

tgttacccac gtgccaccaa atgtgagcct tccccttgga catcttgtaa gtccggagcc     1320

atagaaagca cggccccagc ttgcacatcc tcatccccct gcagcttaaa ggagcactgc     1380

agtgcctgcg gacccctgtc ccggatactg gttaaaattt gcaccatcac caaggagatt     1440

aaggatggga aggtcatttc ttcttacgag catgtgcagc cttgtttcat catcagacct     1500

gccaaagtct aacatcccaa ggtgatgaaa atgacccaca tttatgaaac agaggccaat     1560

acatgctcct gccagagagg tttaagaaaa ctccccagtc ccttaaggta cttagtttct     1620

tactactaca gcgggtcccc attgctaggt agaatatctt ttattctgct ccttccctaa     1680

ctcaccactg ctaaca                                                     1696


<210> 1365
<211> 3503
<212> DNA
<213> Homo sapiens

<400> 1365
gtttgtggcc caggtgcagg aagcttacgc ggtggcagcc gctcgctgag gtagtctctc       60

gcggcgccgg ggatccctga acacagacag cgcgggactg agaaggaaag cttctttctg      120

ggcagccaga gccgcaaagg tggagccgcg ttggcgccct ccgcgggacc agcgcctcgg      180

atgcgggcgg agcgcggggg gccgcggctg cgggagcgcg aagcgggggg ccaggggcgc      240

ctcatgtgag agccgcggga cctgcagccg ccgccgtccc cggagcacgg ggtggtgtgt      300

gggggaagcc gcccccggca gcaggatgaa acgaggagga agagatagtg accgtaattc      360

atcagaagaa ggaactgcag agaaatccaa gaaactgagg actacaaatg agcattctca      420

gacttgtgat tggggtaatc tccttcagga cattattctc caagtattta aatatttgcc      480

tcttcttgac cgggctcatg cttcacaagt ttgccgcaac tggaaccagg tatttcacat      540

gcctgacttg tggagatgtt ttgaatttga actgaatcag ccagctacat cttatttgaa      600

agctacccat ccagagctga tcaaacagat tattaaaaga cattcaaacc atctacaata      660

tgtcagcttc aaggtggaca gcagcaagga atcagctgaa gcagcttgtg atatactatc      720

gcaacttgtg aattgctctt taaaaacact tggacttatt tcaactgctc gaccaagctt      780

tatggattta ccaaagtctc actttatctc tgcactgaca gttgtgttcg taaactccaa      840

atccctgtct tcgcttaaga tagatgatac tccagtagat gatccatctc tcaaagtact      900

agtggccaac aatagtgata cactcaagct gttgaaaatg agcagctgtc ctcatgtctc      960

tccagcaggt atcctttgtg tggctgatca gtgtcacggc ttaagagaac tagccctgaa     1020

ctaccactta ttgagtgatg agttgttact tgcattgtct tctgaaaaac atgttcgatt     1080

agaacatttg cgcattgatg tagtcagtga gaatcctgga cagacacact tccatactat     1140

tcagaagagt agctgggatg ctttcatcag acattcaccc aaagtgaact tagtgatgta     1200

ttttttttta tatgaagaag aatttgaccc cttctttcgc tatgaaatac ctgccaccca     1260

tctgtacttt gggagatcag taagcaaaga tgtgcttggc cgtgtgggaa tgacatgccc     1320

tagactggtt gaactagtag tgtgtgcaaa tggattacgg ccacttgatg aagagttaat     1380

tcgcattgca gaacgttgca aaaatttgtc agctattgga ctaggggaat gtgaagtctc     1440

atgtagtgcc tttgttgagt ttgtgaagat gtgtggtggc cgcctatctc aattatccat     1500

tatggaagaa gtactaattc ctgaccaaaa gtatagtttg gagcagattc actgggaagt     1560

gtccaagcat cttggtaggg tgtggtttcc cgacatgatg cccacttggt aaaaactgca     1620

tgatgaatag caccttaatt tcaagcaaat gtattataat taaagtttta tttgctgtag     1680

ttctgatata attctactat tttgtggcac agaaatttga tatcttcagt cagtatatgt     1740

aaagattgtt tatcggaaga cccatgaatg agttttggtc agaaaattcc acttgtttcc     1800

ttagtgtaat agcagtcata tctccgaatt ttttttaatg tggttcggat gtgaaataac     1860

cagttatacg tattaaacag tttacagtct aaaggaaaca aaacctatat gttataatat     1920

ccaagaagta ctaataggtt ttctgaaatg ttatattctc tatgcattta aaaaaaaatg     1980

taaacttgac attttagggt cttcagttac acatacacct gttataaggt gtttaatata     2040

gctcaggaaa gtgagcattt tgtgagaaaa atgaatatat catatctaat ggaaaagatt     2100

ggatgaatgt tctcaaatgt tacaaagctg tttaaagaaa aaggtatata taagtaatca     2160

gaacacttag aagactgata gatgtcacac agtggtatta tagaaggata atacagagcc     2220

aagatcaaat taaaagacaa taaatggaac agaagggagg cagtgtttag ctttgtataa     2280

acttttaggt ttgctctgta atctgctaaa ccatatacat tcttttgtga tatgttatta     2340

tgtatgtggc acttgaggca ctgtatgtaa agtaaggaat gctttactag ttctccttgg     2400

ttttatcttt gtttaaacta gctttaaagt attaaacaat aattgaaatg aaaagcttac     2460

ctattttaaa aagccaaatt taaataaata tagaacttta aaatgtttat cagttgtttc     2520

catgaaagaa tattagtttc cagtaaattt tagtgatggc tcactcactt ttctattttg     2580

gaattacata gttatgtaag taaaattttt aaaaatcata aagggagcac cattgtacag     2640

tctagcataa acagcaaatt ttaaagagga catatttaag ttcataatca tatttttcag     2700

taaatattgc tcagtgaact ggaaaacttt aatagaaaaa tgtctgcagt tttgtgattg     2760

ttaatttggt taaaccgata ttttatatta tttaagttag gtaacatttt atattacttt     2820

catatgaata aaagtaatcc atgcattgta gagtctataa aatgttgagt tttaaaagat     2880

gatataaact ttgatgctgg gcactagtgc tagtagatat tactaccctc ctgagggaaa     2940

tcagaaatga tttaaccccg gtggaataca ttaattctta aagcggctct tttcagtggt     3000

gtgactttta gattgtgtct cagtggttga ggaagctaac agtcttagat ctacttttaa     3060

aacggatggc cttcttaaga ataaagcaaa aggtgatttt ctacataatt tttgctttcc     3120

aaaagtgatg atatgctctc ctacagcaac atatgagaag aaaaaaggct tatctagatt     3180

cgaaaattaa cagcaattat agtaatatat cccctccttc taaatagtaa aaagctctga     3240

ttgtacaaga attacctgtg ctagtcaagt tgttgttttt ccttgaacaa ctttggaaaa     3300

atggatttga cagtacataa tcagttctac taaccaaagc ttgtatttgg aaatttactt     3360

tttgtacaaa ttgaattata taatgcttaa aatactttgt cactttataa gcaaaatgca     3420

tagtacttaa tttgtttata ctgtaaagta tatgttaaat gcttttatca ctttgagaat     3480

aaaaagttac taatgctgtt gta                                             3503


<210> 1366
<211> 4622
<212> DNA
<213> Homo sapiens

<400> 1366
ttttattacg tctctccttg tggattacgt agaactttgg aaaattaaac attagacatc       60

ttcatagaaa atcatgtcac tgatttttaa agccagctca atttaacctg ccactgattc      120

cctaaccagc tcttctctga ctgtatcccg agggaaaatg tattgaacgc agcagaaggt      180

taaggcagag gagttcggct agaccgggta gcagccaatc agatggggag ggtccaagga      240

tctgatgcct ccaggcgagc agcgccaagc tgagctggtt agtctccttt tattgtggat      300

gaacaccacg tacatgccgt aaatgctccc taggctggct gcggctacaa ggcagacccg      360

ggagctgaga atagaggaat acctgcccaa gcaactcatt ctgcacagca gccgacaaga      420

cagcgatttt cctgtgctgg aatgtgccca tccaaagcca accaatttgt tggaaaatca      480

gtcaaaatct aattttgatg ttctgcaagt tccctggggg ccatgaagca cctgacactt      540

ggattggact taatcttaaa cctctggagt tcaagacctt ttaaaaaggg ctaaataaac      600

aatctctaca tgtaaaaggc cactgactcc tacttcctct gtatagagca actgttgaac      660

tcagctgcct gtaggaaaac tgaagacttt aataacaaac tctccaaggt gaaaatgaac      720

acagatagcg gtgggtgtgc tcgcaaacgt gccgccatgt ctgttacgct aacatctgtg      780

aagagagtgc aaagttctcc aaacctattg gctgcagggc gtgattctca gtcaccagac      840

tcagcttgga gatcttacaa tgatggcaat caggagacac tgaacggaga tgctacatat      900

tcctctcttg cagcaaaagg ttttagaagc gttcgaccaa acctacaaga taaaagatca      960

ccaactcaga gccagataac agtgaatgga aactcaggag gtgccgtgag tcccatgagt     1020

tactatcaga ggccgttttc cccctcggca tattctctcc cagcctcact caactccagc     1080

attgtcatgc agcacggcac atccctcgat tccacagaca catatcccca gcatgcgcag     1140

tctctggatg gcaccaccag cagctctatc cccctgtacc gatcctcaga ggaagagaag     1200

agagtgacag tcatcaaagc cccgcattac ccagggatcg ggcccgtgga tgaatccgga     1260

atccccacag caattagaac gacagtcgac cggcccaagg actggtacaa gacgatgttt     1320

aagcaaattc acatggtgca caagccggat gatgacacag acatgtataa tactccttat     1380

acatacaatg caggtctgta caacccaccc tacagtgctc agtcacaccc tgctgcaaag     1440

acccaaacct acagacctct ttccaaaagc cactccgaca acagccccaa tgcctttaag     1500

gatgcgtcct ccccagtgcc tcccccacat gttccacctc cagtcccgcc gcttcgacca     1560

agagatcggt cttcaacaga aaagcatgac tgggatcctc cagacagaaa agtggacaca     1620

agaaaatttc ggtctgagcc aaggagtatt tttgaatatg aacctggcaa gtcatcaatt     1680

cttcagcatg aaagaccagc ctccttgtat cagtcctcta tagacagaag cctggaaaga     1740

cccatgagtt ctgcaagcat ggccagtgac ttcaggaagc ggaggaagag cgagcctgca     1800

gtgggtccac cacggggctt gggagatcaa agtgcgagca ggactagccc aggccgagtg     1860

gacctcccag gatcaagcac cactcttaca aagtctttca ctagctcttc tccttcttcc     1920

ccatcaagag caaaaggtgg ggatgatagc aaaatatgtc catccctttg cagttactca     1980

gggctcaacg gcaacccctc cagtgagtta gattactgta gcacttacag acagcacttg     2040

gatgtccctc gggactcacc aagagccatt agtttcaaga acggctggca aatggcccgg     2100

caaaacgcag aaatctggag cagcacggaa gaaaccgtct ctcccaaaat caaatcccgg     2160

agctgtgacg atctcctaaa cgacgactgc gatagcttcc cggacccgaa agtcaagtcg     2220

gaaagcatgg gctccctgtt atgtgaggag gactccaagg agagctgccc catggcgtgg     2280

gggtccccct acgtcccgga ggttcgcagt aacggcagat caaggatcag acacaggtca     2340

gcccgcaacg ccccggggtt cctgaagatg tacaagaaaa tgcaccgcat caaccgcaag     2400

gacctgatga actccgaggt gatctgctcc gtgaagtcca ggattctgca gtacgagagc     2460

gagcagcagc acaaggacct gctgcgcgcc tggagccagt gctccacgga ggaggtgccc     2520

cgggacatgg tgcccacacg catctccgaa ttcgaaaagc tgatccagaa gtccaaatcc     2580

atgccaaatt taggggatga catgctgtct cccgtaaccc tagaaccacc gcaaaatggc     2640

ctatgtccca agaggcggtt ttccattgag tatttgctgg aggaagaaaa tcaaagcggc     2700

ccccccgctc ggggccggcg aggctgccag tctaacgccc tggtgcccat tcacattgaa     2760

gtcaccagcg atgagcagcc ccgagcacac gtggagtttt ccgacagcga ccaggacggg     2820

gttgtgtccg accacagtga ctacattcac ctagaggggt catccttctg cagtgaaagt     2880

gactttgatc acttttcctt cacatcctcc gaaagctttt acggatccag ccaccaccac     2940

caccatcacc accaccacca ccaccgccac ctcatcagct cctgcaaagg caggtgcccg     3000

gcctcctaca ctcgatttac cacaatgtta aaacacgaaa gagccagaca cgaaaacacc     3060

gaggagccca gaaggcaaga aatggaccct ggcctttcta aacttgcttt tctagtcagt     3120

cctgtgcctt tccggaggaa aaaaaattcg gctcctaaga aacagactga aaaggcaaaa     3180

tgtaaagcat ctgtgtttga ggctctggac tctgccctta aagacatctg tgaccaaatt     3240

aaagctgaaa agaaaagggg gagcttgccg gacaacagca tcctgcaccg cctcatcagt     3300

gagctgctgc cagatgttcc cgagaggaac tcatccctga gagcgctgag gaggagcccc     3360

ctgcaccagc ctctccaccc actgcctccc gatggtgcta ttcattgtcc accctaccag     3420

aatgactgcg ggagaatgcc ccgcagtgcc tctttccaag acgtggacac agccaacagc     3480

agctgccacc accaagaccg tggcggtgca ctccaagacc gtgagtcccc tagaagttac     3540

tcatccactt tgactgacat ggggagaagt gcaccaaggg aaagaagagg aactccagaa     3600

aaagagaaat tgcctgcaaa agctgtttat gattttaagg ctcagacatc taaggagttg     3660

tcatttaaga aaggagatac tgtctacatc ctcaggaaaa ttgatcaaaa ttggtatgag     3720

ggagaacacc acgggagagt gggcatcttc ccgatctcat acgtagagaa actcacacct     3780

cctgagaaag cacagcctgc aagaccacct ccgccagccc agcccggaga aatcggagaa     3840

gctatagcca aatacaactt caacgcagac acaaatgtgg agctgtcact gagaaaggga     3900

gatagagtta ttcttcttaa aagagttgat caaaactggt atgaaggtaa aatcccagga     3960

accaacagac aaggcatctt ccctgtttcc tatgtggagg tcgtcaagaa gaacacaaaa     4020

ggtgctgagg actaccctga ccctccaata ccccacagct attctagtga taggattcac     4080

agcttgagct caaataagcc acagcgtcct gtgtttactc atgaaaatat tcaaggtggg     4140

ggggaaccgt ttcaggctct gtataactat actcccagga atgaagatga gctggagctc     4200

agagaaagtg atgtcattga tgtcatggaa aagtgtgatg acggctggtt tgtggggacc     4260

tcaagaagaa ccaaattctt tggtactttc cccggaaact acgtcaagag gctgtgaatt     4320

gcgctccctc cttctgtaga ggccgcctgc cagccatgca cctgcgtcaa cgcgcctgaa     4380

acaccccgcg ggcctcccgt tgtcatgcct tacggtttcc aatgcgccgt caccatctcc     4440

acctgccacc aaaccaccag cagagtagcc gccgctgctg tgagcctggg gacgacatgg     4500

caggctggtc cccctccgtg aaagtgtgga ttcctacttc ctgctctaag ctttgacacg     4560

tcaaaatgtg ggatcagaaa gaaaaaaatc atgatattta aaaatggtca aatatttgag     4620

gc                                                                    4622


<210> 1367
<211> 1950
<212> DNA
<213> Homo sapiens

<400> 1367
gcacacgcgc ctcttcacga ggtggaaaca agatggagga ttcggcctcg gcctcgctgt       60

cttctgcagc cgctactgga acctccacct cgactccagc ggccccgaca gcacggaagc      120

agctggataa agaacaggtt agaaaggcag tggacgctct cttgacgcat tgcaagtcca      180

ggaaaaacaa ttatgggttg cttttgaatg agaatgaaag tttattttta atggtggtat      240

tatggaaaat tccaagtaaa gaactgaggg tcagattgac cttgcctcat agtattcgat      300

cagattcaga agatatctgt ttatttacga aggatgaacc caattcaact cctgaaaaga      360

cagaacagtt ttatagaaag cttttaaaca agcatggaat taaaaccgtt tctcagatta      420

tctccctcca aactctaaag aaggaatata aatcctatga agccaagctc cgccttctga      480

gcagttttga tttcttcctt actgatgcca gaattaggcg gctcttaccc tcactcattg      540

ggagacattt ctatcaaaga aagaaagttc cagtatctgt aaaccttctg tccaagaatt      600

tatcaagaga gatcaatgac tgtataggtg gaacagtctt aaacatttct aaaagtggtt      660

cttgcagtgc tatacgtatt ggtcacgttg gaatgcaaat tgagcacatc attgaaaaca      720

ttgttgctgt caccaaagga ctttcagaaa aattgccaga gtgggagagc gtgaaactcc      780

tgtttgtgaa aactgagaaa tcggctgcac ttcccatctt ttcctcgttt gtcagcaatt      840

gggatgaagc caccaaaaga tctttgctta ataagaagaa aaaagaggca aggagaaaac      900

gaagagaaag aaattttgaa aaacaaaagg agaggaagaa gaagaggcag caggctagga      960

agactgcatc agttcttagt aaagatgatg tggcacctga aagtggtgat actacagtga     1020

agaaacctga atcaaagaag gaacagaccc cagagcatgg gaagaaaaaa cgtggcagag     1080

gaaaagccca agttaaagca acaaatgaat ccgaagacga aatcccacag ctggtaccaa     1140

taggaaagaa gactccagct aatgaaaaag tagagattca aaaacatgcc acaggaaaga     1200

agtctccagc aaagagtcct aatcccagca cacctcgtgg gaagaaaaga aaggctttgc     1260

cagcatctga gaccccaaaa gctgcagagt ctgagacccc agggaaaagc ccagagaaga     1320

agccaaaaat caaagaagag gcagtgaagg aaaaaagtcc ttcgctgggg aaaaaagatg     1380

cgagacagac tccaaaaaag ccagaggcca agtttttcac cactcctagt aaatctgtga     1440

gaaaagcttc ccacaccccc aaaaaatggc ccaaaaaacc caaagtaccc cagtcgacct     1500

aaagtcagtg attcaactgg aaggaaacct caatgctgcc tccagagctt tttggaaata     1560

ctcagatcct ggccgccttt gtaaccttct ctaaacgtca ggcctggact taaaagattt     1620

tttaaaacct ccataagtag tccaggggcg gtggctcacg cctgtaatcc cagcactttg     1680

ggaggccgag gcaggcggat cacaaggtca acgagatcga gaccatcctg gccaacatgg     1740

tgaaaccctg tctgtaccaa aaatacaaaa attaattggg catggtggtg gacacctgta     1800

atcccagcta ctagggaggc tgaggcagga gaattgcttg aacctgggag gcggaggttg     1860

cagtgagcca ctgcactcca gcctgatgac agagcaagac tcagtctcaa aaataaataa     1920

aaataataaa acctccataa gtaatcctga                                      1950


<210> 1368
<211> 3290
<212> DNA
<213> Homo sapiens

<400> 1368
ggtgcttgcc ctgcccatcc ccgtggcggg ggcgtggcca tggcgggggc gctccggcgg       60

gggcgggccc tgggctcccg cccttcgggt cccacagttt ccagccgccg ctctcctcag      120

tgcccggtgg cccaggaggg cctgggagcc cgaagccgtc cccgagtcgc tcctaggtca      180

ctggcgcgat gcgggccgtc ctctcggctg atgggttgga agcccagcga ggctagaggc      240

cagtcccaaa gtttccaggc atcagggctg cagcccagga gcctcaaggc ggcccggcgg      300

gcgactggac ggccggacag gtcccgagca gccccgccca acatggaccc agacccccag      360

gcgggcgtgc aggtgggcat gcgggtggtg cgcggcgtgg actggaagtg gggccagcag      420

gacggcggcg agggcggcgt gggcacggtg gtggagcttg gccgccacgg cagcccctcg      480

acacccgacc gcacagtggt cgtgcagtgg gaccagggca cgcgcaccaa ctaccgcgcc      540

ggctaccagg gcgcgcacga cctgctgctg tacgacaacg cccagatcgg cgtccggcac      600

cccaacatca tctgtgactg ctgcaagaag cacgggctgc gggggatgcg ctggaagtgc      660

cgtgtgtgcc tggactacga cctctgcacg cagtgctaca tgcacaacaa gcatgagctc      720

gcccacgcct tcgaccgcta cgagaccgct cactcgcgcc ctgtcacact gagtccccgc      780

cagggcctcc cgaggatccc actaaggggc atcttccagg gagcgaaggt ggtgcgaggc      840

cccgactggg agtggggctc acaggatgga ggggaaggga aaccgggccg tgtggtggac      900

atccgtggct gggatgtgga gacaggccgg agtgtggcca gcgtgacgtg ggctgatggt      960

accaccaatg tgtaccgtgt gggccacaag ggcaaggtgg acctcaagtg tgtgggcgag     1020

gcagcgggcg gcttctacta caaggaccac ctcccaaggc tcggcaagcc ggcggagctg     1080

cagcgcaggg tgagtgctga cagccagccc ttccagcacg gggacaaggt caagtgtctg     1140

ctggacactg atgtcctgcg ggagatgcag gaaggccacg gcggctggaa ccccaggatg     1200

gcggagttta tcggacagac gggcaccgtg catcgtatca cggaccgcgg ggacgtgcgc     1260

gtgcagttca accacgagac gcgctggacc ttccaccccg gggcgctcac caagcaccac     1320

tccttctggg tgggcgacgt ggtccgggtc atcggcgacc ttgacacagt gaagcggctg     1380

caggctgggc atggcgagtg gacggacgac atggcccctg ccctgggccg cgtcgggaag     1440

gtggtgaaag tgtttggaga cgggaacctg cgtgtagcag tcgctggtca gcggtggacc     1500

ttcagcccct cctgcctggt ggcctaccgg cccgaggagg atgccaacct ggacgtggcc     1560

gagcgcgccc gggagaacaa aagctcactg agcgtggccc tggacaagct tcgggcccag     1620

aagagtgacc cagagcaccc gggaaggctg gtggtggagg tggcgctggg taacgcagcc     1680

cgggctctgg acctgctgcg gaggcgccca gagcaggtgg acaccaagaa ccaaggcagg     1740

accgctctgc aagtggctgc ctacctgggc caggtggagt tgatacggct gctgctacaa     1800

gccagggcgg gcgtggacct gccggacgac gagggcaaca cggcactgca ctacgcggcc     1860

ctggggaacc agcccgaggc caccagggtg ctcctgagtg ctgggtgccg ggcggacgcc     1920

atcaacagca cccagagcac agcactgcac gtggccgtgc agaggggctt cctggaggtg     1980

gtgcgggccc tgtgtgagcg cggctgtgac gtcaacctgc ccgacgccca ctcggacacg     2040

cccctgcact ccgccatctc ggcgggcact ggagccagcg gcattgtcga ggtcctcacg     2100

gaggtgccaa acatcgatgt taccgccacc aacagccagg gtttcaccct gctgcaccat     2160

gcctccctca agggtcacgc gctagctgtg agaaagattc tggctcgggc gcggcagctg     2220

gtggacgcca agaaggagga cggcttcacg gcgctgcatc tggctgccct caacaaccac     2280

cgcgaggtgg cccagatcct catccgggag ggccgctgtg acgtgaacgt gcgcaaccgg     2340

aagctgcagt ccccgctgca tctcgccgtg caacaggccc acgtggggct ggtgccgcta     2400

ctggtggacg ctgggtgcag tgtcaacgcc gaggacgagg agggggacac agccctgcac     2460

gtggcgctgc agcgtcatca gctgctgccc ctggtggctg atggggccgg gggggaccca     2520

gggcccttgc agctgctgtc caggctacag gcctcgggcc tccccggcag cgcggagctg     2580

acggtgggcg cggcggtcgc ctgcttcctg gcgctggagg gcgccgacgt gagctacacc     2640

aaccaccgcg gtcggagccc gctggacctg gccgccgagg gtcgcgtgct caaggccctt     2700

cagggctgcg cccagcgctt ccgggagcgg caggcgggcg ggggcgcggc cccgggcccc     2760

aggcaaacgc tcgggacccc caacaccgtg acgaacctgc acgtgggcgc cgcgccgggg     2820

cccgaggccg ctgagtgcct ggtgtgctcc gagctggcgc tgctggtgct gttctcgccg     2880

tgccagcacc gcaccgtgtg tgaggagtgc gcgcgcagga tgaagaagtg catcaggtgc     2940

caggtggtcg tcagcaagaa actgcgccca gacggctctg aggtggcgag cgccgccccc     3000

gcccccggcc cgccgcgcca gctggtggag gagctgcaga gccgctaccg gcagatggag     3060

gaacgcatca cctgccccat ctgcatcgac agccacatcc gcctcgtgtt ccagtgcggc     3120

cacggcgcat gcgccccctg cggctccgcg ctcagcgcct gccccatctg ccgccagccc     3180

atccgcgacc gcatccagat cttcgtgtga gccgcgccgt ccgccgcgcc cgagctgcct     3240

tcgcgtgccc ccgccctgtg ttttataaaa agaaagattc tcggacgttg                3290


<210> 1369
<211> 1602
<212> DNA
<213> Homo sapiens

<400> 1369
cggcaccgcg cgggacggag cttggctgtt ggtcggtggg ttcccgtgcg gcggcggcca       60

aggaggagga gacacagttg gagcagctcc gtgggctgac tggggcgagg cctcagcagc      120

gcgagcttga gtgcggccga gcctgcggcg ccttcccctg cgggtgggga cgagcgggcc      180

ccgcggcgtc atcggcggcg aggagccgcc gcgcctcggc ctagcatgtc ggaagcgggc      240

gaggagcagc ccatggagac gacgggcgcc accgagaacg gacatgaggc cgtccccgaa      300

ggcgagtcgc cggccggggc tggcacgggc gccgcggcgg gggctggagg cgcgaccgcg      360

gcgcccccga gcgggaatca gaacggcgcc gagggcgacc agatcaacgc cagcaagaac      420

gaggaggacg cgggaaaaat gttcgttggt ggcctgagct gggatactag caaaaaagat      480

ttaaaagact attttactaa atttggagag gtcgttgact gtacaataaa aatggatccc      540

aacactggac ggtcaagagg gtttgggttt atcctgttca aagatgcagc cagtgtggag      600

aaggtcctag accagaagga gcacaggctg gatggccgtg tcattgaccc taaaaaggcc      660

atggctatga agaaggaccc ggtgaagaaa atcttcgttg ggggtctgaa tcctgaagcc      720

actgaggaaa agatcaggga gtactttggc gagtttgggg agattgaggc cattgaattg      780

ccaatggatc caaagttgaa caaaagacga ggttttgtgt ttatcacctt taaagaagaa      840

gaacccgtga agaaggttct ggagaaaaag ttccatactg tcagtggaag caagtgtgag      900

atcaaggtgg cccagcccaa agaagtctat cagcagcagc agtatggctc tgggggccgt      960

ggaaaccgca accgagggaa ccgaggcagc ggaggtggtg gtggaggtgg aggtcagggt     1020

agtacaaact acggcaagag ccagcgacgt ggtggccatc agaataacta caagccatac     1080

tgaggcggca gcaggagcga ccaactgatc gcacacatgc tttgtttgga tatggagtga     1140

acacaattat gtaccaaatt taacttggca aactttctat tgcctgtccc atgtgcatct     1200

tatttaaaat ttcccccatg gaaatcactc tcctgttgac tatttccaga gctctaggtg     1260

tttaggcagc gtgtggtgtc tgagaggcca tagcgccatc atgggctgat ttttattacc     1320

aggtccccca gaagcaggtg ggaggctctg cttcctgctg ccgctctgca gcctggacct     1380

gtggaccctg gttgtaaaga gtaaattgta tcttaggaaa ccagtgtcac ctttttttca     1440

ccttttaatt ttatattatt tgcgtcatac atttcctgta acggaagtgt taattttact     1500

gtactttttg gtaccttttg ggaatctaat gtattgtaag gtattttaca cgtgtcctga     1560

ttttgccaca acctggatat tgaagctatc caagcttttg aa                        1602


<210> 1370
<211> 2015
<212> DNA
<213> Homo sapiens

<400> 1370
gtcaaacccc tcattgttcg cagctgatgt cactcgcagt tgtgagcggc cgcctctccc       60

ggggacaatg tgggactgag cggcccagcc gccgtgccgc cgccgccgcc gccgcaggac      120

agccccagcg agagccggcc aggttgcagc gcggacacac tcgcaggtcg ctgtggcccc      180

agcctcgcct gacagaatga gcggctcgga cgggggactg gaggaggagc cagagctcag      240

catcaccctc acgctgcgga tgctgatgca cgggaaggaa gtgggcagca tcatcgggaa      300

gaagggcgag actgtaaagc gaatccggga gcagagcagt gcccggatca ccatctccga      360

gggctcctgc cctgaacgca tcaccaccat caccgggtct acagcagctg tcttccatgc      420

agtctccatg attgctttca aactggatga ggacctttgt gctgctcctg caaatggtgg      480

aaatgtctcc aggcctccag tgaccctgcg ccttgtcatc cctgccagtc agtgtggctc      540

actgattggg aaggctggca ccaagatcaa ggagatccga gagactacgg gtgcccaggt      600

acaggtggca ggggacctgc tccccaactc cacagagcga gctgttacgg tatctggggt      660

gcctgatgcc atcatcctgt gtgtgcgcca gatctgcgct gttatcctgg agtccccacc      720

caaaggagcc actatcccct accatccgag cctctcccta ggtactgttc ttctctctgc      780

caaccagggc ttctctgtcc agggtcagta tggggctgtg accccagctg aggtcaccaa      840

gctccagcag ctctcaagcc atgcggtccc ctttgccaca cccagcgtgg tgccaggact      900

ggatcccggc acacagacca gctcacagga gttcttggtt cccaacgatt tgattggctg      960

tgtgatcggg cgccagggca gcaagatcag cgagatccgg cagatgtcag gggcacatat     1020

caagatcggg aaccaagcag agggcgctgg ggagcggcat gtcaccatca ctggctctcc     1080

ggtctccatc gccctggccc agtacctcat cactgcctgt ctagagacgg ccaagtctac     1140

ctctgggggg acgcccagct cggcccccgc agacctgcct gcccccttct cgccacccct     1200

gacggccctg cccacagctc cccctggcct gctgggcaca ccctatgcca tctccctctc     1260

caacttcatc ggcctcaagc ccatgccctt cttggcttta ccacctgctt ccccagggcc     1320

gccgccgggc ttggcggcct acactgccaa gatggcagca gctaatggga gcaagaaggc     1380

tgagcggcag aaattctccc cctactgagg ccagctgagg tacaggcagg ggcaggcagg     1440

accaccagca gggggctgcc tctgcaccct acccgcccaa ggagactcca ccctggggtc     1500

ccaaacgccg ctaacgccca gacgcatgga tgcaccccct accctgcctc catctatggg     1560

agttctttct ctcagagtgg gggcagtttc tggcccaggg gtctgagctg cggcagcccc     1620

agggcagggg gccctacctc ctcagctctg tgcttggata cagggagcag ccaggagact     1680

ccctagtgcc cccaccatgg cgggtgtcac tcacgcactc cccatccctt agggcttcct     1740

ggcctactgc atccttgtgg gagtcaggga ggagggcccg ttgggtagct ggggccaggc     1800

ttctctcccc accacctgca gatttcttgc tgcttccact gatacccttt tgactggaat     1860

gaactggctg ggcttgtcag ggggcacccc aaagaggggg cactgccagg tagctggggg     1920

agtggcatgg ggcaggggcc cagttctcag cagcagacac tctgtacagt tttttcaatc     1980

cctgtttttg aataaatatt ctcagcgacc aggaa                                2015


<210> 1371
<211> 1720
<212> DNA
<213> Homo sapiens

<400> 1371
cgcgccgctt ccggtctgca gccttgtagt ggggctggag cagagcctgc cgcgaacccc       60

cggagcccac gatccctcgt gccatccctc gaatccacca gcacgagcgt cccacccgcg      120

cctgggacca tggccactga ctcatgggcc ctggcggtgg acgagcagga agctgcggct      180

gagtcgttga gcaacttgca tcttaaggaa gagaaaatca aaccagatac caatggtgct      240

gttgtcaaga ccaatgccaa tgcagagaag acagatgaag aagagaaaga ggacagagct      300

gcccagtcct tactcaacaa gctgatcaga agcaaccttg ttgataacac aaaccaagtg      360

gaagtcctgc agcgggatcc aaactcccct ctgtactcgg tgaagtcttt tgaagagctt      420

cggctcccac agaacttaat tgcccaatct cagtctggta ctggtaaaac agctgccttc      480

gtgctggcca tgcttagcca agtagaacct gcaaacaaat acccccagtg tctatgtctc      540

tccccaacgt atgagctcgc cctccaaaca ggaaaagtga ttgaacaaat gggcaaattt      600

taccctgaac tgaagctagc ttatgctgtt cgaggcaata aattggaaag aggccagaag      660

atcagtgagc agattgtcat tggcacccct gggactgtgc tggactggtg ctccaagctc      720

aagttcattg atcccaagaa aatcaaggtg tttgttctgg atgaggctga tgtcatgata      780

gccactcagg gccaccaaga tcagagcatc cgcatccaga ggatgctgcc caggaactgc      840

cagatgctgc ttttctccgc cacctttgaa gactctgtgt ggaagtttgc ccagaaagtg      900

gtcccagacc caaacgttat caaactgaag cgtgaggaag agaccctgga caccatcaag      960

cagtactatg tcctgtgcag cagcagagac gagaagttcc aggccttgtg taacctctac     1020

ggggccatca ccattgctca agccatgatc ttctgccata ctcgcaaaac agctagttgg     1080

ctggcagcag agctctcaaa agaaggccac caggtggctc tgctgagtgg ggagatgatg     1140

gtggaacaga gggctgcagt gattgagcgc ttccgagagg gcaaagagaa ggttttggtg     1200

accaccaacg tgtgtgcccg cggcattgat gttgaacaag tgtctgtcgt catcaacttt     1260

gatcttcccg tggacaagga cgggaatcct gacaatgaga cctacctgca ccggatcggg     1320

cgcacgggcc gctttggcaa gaggggcctg gcagtgaaca tggtggacag caagcacagc     1380

atgaacatcc tgaacagaat ccaggagcat tttaataaga agatagaaag attggacaca     1440

gatgatttgg acgagattga gaaaatagcc aactgagaag ctccaccagc cactgatgcc     1500

agccctggca ctgcccctgc acaggagaca agtgcgttca gggcacaggc cccgacatca     1560

ccccaaggac aacggcacaa gtagagagaa actacctacc tcacttcaaa ttatgtttgg     1620

acttgacaaa aatgtatgca aatgatgggg gatggtagaa aaaaattatt tacacaacct     1680

tggaagatta ggcatgaata cacagagatt taccttttgg                           1720


<210> 1372
<211> 2670
<212> DNA
<213> Homo sapiens

<400> 1372
gctcgcaggc gggggtttcc atggtgatgg tcaacaagcc tcaactgcct ctgctacaac       60

tgccaagttc cccgcgtccc accctcctct aggtgctcca agggaccacc ggggtgcctg      120

atatgagagc gggagtgtag agactcggag gccgaggttg agaacaaaaa catgcacctg      180

gagtttcccc ggagccctct gcgtggttga gcttcggtgg aatttcgggg ctcttggctg      240

ccagccgcgc ttgcctggta gcaacagaaa ccagtcctgc tcgcctccgt ggacatttca      300

ttaccatcca gaagtgtctc ccactgaagg catccgtggt tgtttttaag ccacaaaaaa      360

gccacaccca agatcacctg acacccaccc tgacaagtgt ccatgatgct gggccctgag      420

ggaggtgaag gctttgtggt caagctccgt ggcctgccct ggtcctgctc tgttgaggac      480

gtgcagaact tcctctctga ctgcacgatt catgatgggg ccgcaggtgt ccatttcatc      540

tacactagag agggcaggca gagtggtgag gcttttgttg aacttggatc agaagatgat      600

gtaaaaatgg ccctgaaaaa agacagggaa agcatgggac accggtacat tgaggtgttc      660

aagtcccaca gaaccgagat ggattgggtg ttgaagcaca gtggtcccaa cagtgccgac      720

agcgccaacg atggcttcgt gcggcttcga ggactcccat ttggatgcac aaaggaagaa      780

attgttcagt tcttctcagg gttggaaatt gtgccaaacg ggatcacatt gcctgtggac      840

cccgaaggca agattacagg ggaagcgttc gtgcagtttg cctcgcagga gttagctgag      900

aaggctctag ggaaacacaa ggagaggata gggcacaggt acattgaggt gtttaagagc      960

agccaggagg aagttaggtc atactcagat ccccctctga agttcatgtc cgtgcagcgg     1020

ccagggccct atgaccggcc cgggactgcc aggaggtaca ttggcatcgt gaagcaggca     1080

ggcctggaaa ggatgaggcc tggtgcctac agcacaggct acgggggcta cgaggagtac     1140

agtggcctca gtgatggcta cggcttcacc accgacctgt tcgggagaga cctcagctac     1200

tgtctctccg gaatgtatga ccacagatac ggcgacagtg agttcacagt gcagagcacc     1260

acaggccact gtgtccacat gaggggcctg ccgtacaaag cgaccgagaa cgacatttac     1320

aacttcttct ctcctctcaa ccctgtgaga gtccatattg agattggccc agatggaaga     1380

gtgacgggtg aagcagatgt tgagtttgct actcatgaag aagctgtggc agctatgtcc     1440

aaagacaggg ccaatatgca gcacagatat atagaactct tcttgaattc aacaacaggg     1500

gccagcaatg gggcgtatag cagccaggtg atgcaaggca tgggggtgtc tgctgcccag     1560

gccacttaca gtggcctgga gagccagtca gtgagtggct gttacggggc cggctacagt     1620

gggcagaaca gcatgggtgg ctatgactag ttttgttagg aacatttgag ttacttcaat     1680

cattttcaca ggcagccaac aagcaattaa gagcagttat aatagaggaa gctgggggac     1740

ccattttgca ccatgagttt gtgaaaaatc tggattaaaa aattacctct tcagtgtttt     1800

ctcatgcaaa attttcttct agcatgtgat aatgagtaaa ctaaaactat tttcagcttt     1860

tctcaattaa cattttggta gtatacttca gagtgatgtt atctaagttt aagtagttta     1920

agtatgttaa atgtggatct tttacaccac atcacagtga acacactggg gagacgtgct     1980

tttttggaaa actcaaaggt gctagctccc tgattcaaag aaatatttct catgtttgtt     2040

cattctagtt tatattttca tttaaaatcc tttaggttaa gtttaagctt tttaaaagtt     2100

agttttgaga attgagacac aatactaata ctgtaggaat tggtgaggcc ttgacttaaa     2160

actttctttg tactgtgatt tccttttggg tgtattttgc taagtgaaac ttgttaaatt     2220

ttttgttaac taaatttttt tcttaaaata aagacttttt cacaatgact ggcacagatt     2280

actcagcaaa agatagcaaa acgggtggtt gaagataatt cattttaatc gtaatgtatt     2340

ttagtgtgaa tttaaaaatt tcatacatca aatctatgat ctcccttata ttcttatgat     2400

gaggctaaat aaaagtctaa taaaaatgtt aaatatgtga atggtggaaa tggtgactag     2460

cagcacacat tctgggaagc atcaaataga cacacggccc cagccacctg caacttatgt     2520

gcactgttgt aaaccattca gaattttcct gctaggccct tgatgctgga gtcacatctg     2580

ttgatagctg gagaacttta gtttcaagta ctacattgtg aaagcaatta ttttgtttct     2640

agtttttata aaatgctgat ttaaactttt                                      2670


<210> 1373
<211> 1302
<212> DNA
<213> Homo sapiens

<400> 1373
ctggttctgg aggctgggtt gagaggtcgc cggtccgact gtcctcggcg gttggtcagt       60

gtgaatttgt gacagctgca gttgctcccc gcccccgagc agccgaggtg cgtgggggaa      120

ggggaagaag gaaaaggtcc gggtcgcgtt tccgctcagt ttttgccagg gttgaggcga      180

ttccagagag cggcggaaag gataagcctc gacttagaag ctaccgagtt accctaagaa      240

aggagtctac catggctcaa gaatctccca aaaattcagc agcagaaatt ccagtgacta      300

gtaatggaga agttgatgac tctcgtgaac atagctttaa tagggatttg aagcattcat      360

taccatctgg acttggtctc tcagaaaccc aaattacatc tcatggcttt gacaatacca      420

aagagggtgt tattgaagca ggagcatttc aaggtggcca gagaacacag acaaaaagtg      480

gaccagttat tctagcagat gaaattaaaa atcctgcaat ggaaaagtta gaacttgtta      540

gaaaatggag tctaaacacc tataagtgta ctcgacagat tatctctgag aagctaggcc      600

gtggctcaag aactgtggac cttgaacttg aagctcagat tgatatatta agggataaca      660

agaaaaaata tgaaaatatt ttaaaactgg ctcaaacatt gtcgacccag cttttccaga      720

tggtacatac ccaaaggcaa cttggagatg catttgctga cctgagtttg aagtcactag      780

aacttcatga agaatttggc tataatgccg atacccagaa actgctggct aaaaatggag      840

agactcttct tggggccatt aattttttca ttgctagtgt gaacactttg gtgaataaaa      900

ccattgaaga tacattaatg actgtgaaac agtatgaaag tgccaggatt gaatatgatg      960

catatcgcac tgatttggaa gaactgaatc ttggaccacg tgacgcaaac actctgccaa     1020

agattgagca gtcacagcat ctcttccaag cacataagga aaaatatgat aaaatgcgca     1080

atgatgtttc tgtcaaattg aaatttctag aagaaaataa ggttaaagta ttgcacaatc     1140

agctggtcct tttccacaat gccattgccg cttactttgc tgggaatcag aagcagcttg     1200

aacagacact taaacagttc catatcaaat tgaaaacccc tggagtggat gccccatctt     1260

ggcttgaaga acagtaaaat cacagcggaa aataaaaaga aa                        1302


<210> 1374
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 1374
tggaggccgg gcgcgcgggc cctactcggc agggcctgct cggggccggc ttcgggcctg       60

cccggccggg cctgcccgca cccttccgcc cggcctggcc ggcgccccct cgcgccccgg      120

gcgggccctg cacgtctcgc gagcagcccg gagcggcggg ggaggcgggg cccgcgggct      180

gccgggcagg gccggggcgg tgccgaggcc gggccggagc ggggcgaagg gggccgagcg      240

gcgggccggg ccgggccggg cagggccggg gcgtgggccg gcaggaagat ggcgaacgtg      300

gggctgcagt tccaggcgag cgcgggggac tcggacccac agagccggcc cctgctgctg      360

ctcgggcagc tgcaccacct gcaccgcgtg ccctggagcc acgtccgcgg gaagctgcag      420

ccccgggtca ccgaggagct ctggcaggct gccctgagca cgctcaaccc caaccccacg      480

gacagctgtc ccctctacct gaactacgcc accgtggctg ccctgccctg cagggtgagc      540

cggcacaaca gcccctcggc cgcccacttc atcacgcggc tggtgcggac ctgcctgccg      600

cccggagcgc atcgctgcat tgtgatggtc tgcgagcagc cggaggtctt tgcttccgcc      660

tgtgccctgg cccgggcctt cccgctgttc acccaccgct caggtgcctc tcggcgcttg      720

gagaagaaga cggtcaccgt ggagtttttc ctggtgggac aagacaacgg gccggtggag      780

gtgtccacat tgcagtgctt agcgaatgcc acagacggcg tgcggctagc agcccgcatc      840

gtggacacac cctgcaatga gatgaacacc gacaccttcc tcgaggagat taacaaagtt      900

ggaaaggagc tggggatcat cccaaccatc atccgggatg aggaactgaa gacgagagga      960

tttggaggaa tctatggggt tggcaaagcc gccctgcatc ccccagccct ggccgtcctc     1020

agccacaccc cagatggagc cacgcagacc atcgcctggg tgggcaaagg catcgtctat     1080

gacactggag gcctcagcat caaagggaag actaccatgc cggggatgaa gcgagactgc     1140

gggggtgctg cggccgtcct gggggccttc agagccgcaa tcaagcaggg tttcaaagac     1200

aacctccacg ctgtgttctg cttggctgag aactcggtgg ggcccaatgc gacaaggcca     1260

gatgacatcc acctgctgta ctcagggaag acggtggaaa tcaacaacac ggatgccgag     1320

ggcaggctgg tgctggcaga tggcgtgtcc tatgcttgca aggacctggg ggccgacatc     1380

atcctggaca tggccaccct gaccggggct cagggcattg ccacagggaa gtaccacgcc     1440

gcggtgctca ccaacagcgc tgagtgggag gccgcctgtg tgaaggcggg caggaagtgt     1500

ggggacctgg tgcacccgct ggtctactgc cccgagctgc acttcagcga gttcacctca     1560

gctgtggcgg acatgaagaa ctcagtggcg gaccgagaca acagccccag ctcctgtgct     1620

ggcctcttca tcgcctcaca catcggcttc gactggcccg gagtctgggt ccacctggac     1680

attgctgcac cggtgcatgc tggtgagcga gccacaggct tcggtgtggc cctcctgctg     1740

gcgctcttcg gccgtgcctc tgaggaccct ctgctgaacc tggtgtcccc actgggctgt     1800

gaggtggatg tcgaggaggg ggacctgggg agggactcca agagacgcag gcttgtgtga     1860

gcctcctgcc tcggccctga caaacgggga tcttttacct cactttgcac tgattaattt     1920

taagcaattg aaagattgcc cttcatatgg gttttggttt gtctttctgg tcgtcagcgt     1980

ggtggtggaa acagctgaag ttttaggaga cagcttaggg tttggtgcgg gccacgggga     2040

ggggaccggg aagcgctggg gcttgtttct gtttgttact tacaggactg agacatcttc     2100

tgtaaactgc tacccctggg gccttctgca ccccggggtg aggcctcctg cctgcctggt     2160

gccctgtccc agccccaggt cctgtgcagg gcacctgcgt ggctgacagc caggctctta     2220

ctccagccgg ggctgccagc gcatccagcc agcccagccc tgtgaaagat ggagctgact     2280

tgctgcaggg gacctgattt atagggcaag agaagtcaca ctccggcctc tcagaattca     2340

cttgaggttc aattaaatac agtcacaccg ccccctca                             2378


<210> 1375
<211> 4406
<212> DNA
<213> Homo sapiens

<400> 1375
gcgtgggctc ccgatgggct gcctgagcgg gtgcgcgggc aacttccggt gtgggtgacg       60

agtggtggcc gaagcagggg gacagcaagg gacgctcagg cggggaccat ggcggacggc      120

ggctcggagc gggctgacgg gcgcatcgtc aagatggagg tggactacag cgccacggtg      180

gatcagcgcc tacccgagtg tgcgaagcta gccaaggaag gaagacttca agaagtcatt      240

gaaacccttc tctctctgga aaagcagact cgtactgctt ccgatatggt atcgacatcc      300

cgtatcttag ttgcagtagt gaagatgtgc tatgaggcta aagaatggga tttacttaat      360

gaaaatatta tgcttttgtc caaaaggcgg agtcagttaa aacaagctgt tgccaaaatg      420

gttcaacagt gctgtactta tgttgaggaa atcacagacc ttcctatcaa acttcgatta      480

attgatactc tacgaatggt taccgaaggc aagatttatg ttgaaattga gcgtgcgcga      540

ctgactaaaa cattagcaac tataaaagaa caaaatggtg atgtgaaaga ggcagcctcc      600

attttacagg agttacaggt ggaaacctac gggtcaatgg aaaagaaaga gcgagtggaa      660

tttattttgg agcaaatgag gctctgccta gctgtgaagg attacattcg aacacaaatc      720

atcagcaaga aaattaacac caaatttttc caggaagaaa atacagagaa attaaagttg      780

aagtactata atttaatgat tcagctggat caacatgagg gatcctattt gtctatttgt      840

aagcactaca gagcaatata tgatactccc tgtatacagg cagaaagtga aaaatggcag      900

caggctctga agagtgttgt actctatgtt atcctggctc cttttgacaa tgaacagtca      960

gatttggttc accgaataag tggtgacaag aagttagaag aaattcccaa atacaaggat     1020

cttttaaagc tttttaccac aatggagttg atgcgttggt ccacacttgt tgaggactat     1080

ggaatggaat taagaaaagg ttcccttgag agtcctgcaa cggatgtttt tggttctaca     1140

gaggaaggtg aaaaaaggtg gaaagacttg aagaacagag ttgttgaaca taatattaga     1200

ataatggcca agtattatac tcggataaca atgaaaagga tggcacagct tctggatcta     1260

tctgttgatg agtccgaagc ctttctctca aatctagtag ttaacaagac catctttgct     1320

aaagtagaca gattagcagg aattatcaac ttccagagac ccaaggatcc aaataattta     1380

ttaaatgact ggtctcagaa actgaactca ttaatgtctc tggttaacaa aactacgcat     1440

ctcatagcca aagaggagat gatacataat ctacaataag ggtcttagtg ctttagaaaa     1500

aagttaaaat tggaagtcat taaaaaaaga ctgttataat ggtgtatatg ttggggtttt     1560

ttttctaagc ttctttgtct taaattttaa aatagtgaat atgtttgaga ctccctttga     1620

cctttcagtt ccccaagttc attgttaact ttgcatttgc aattggtgca aaaatacaga     1680

tttctgtcgt ctgaatacac aaaaagttgt gtcataactt acccagatat gtttttctat     1740

catttgaaac ctttttagct actgtttgtt ttcattcaac taacaaacat attccaataa     1800

taaaagcagt atatacatat ttcctttcta cagttacctc tgattctcaa cattttgtgg     1860

ggtagtgatt tggcaagtgt tttttaaata aaacaaatct cattgtaaag ctatcagtca     1920

tttagtagaa tagaaaagca acatagagca tacaagaaca tttgggatag agttgtgatt     1980

tgtgaagaat ttgtactttg atattgtggc ggaaagtcta gactgagtgt gtatgctggt     2040

aaactgtaga cttttttttt tttttttttg agtccggctg gttccaatca cagtagcttg     2100

attgctttca gccctcatcc tctcacttga tcagttgttc aacagaatca gctgacataa     2160

ttgacacagt ttattgggtg ttaagtccgc tctataggga tagtgactac tttttttttt     2220

tttttttttt tgctcttctt cctctcccct ttctttatat gggtttaaat ttaacataaa     2280

gttgttttta taaggcttat ttgtggcttt aacttgtaag tctgattaca tcattattgt     2340

tccaaattca ttatctctgt aggaactttt agttccatta tatgaacact ggataaccta     2400

atttttttta atgctttaaa aaaatggcaa aaagacgtca ggccaccctc atagtaagtg     2460

gtgtagtatt aaaatatttt cacggaatta aaagtagctt gctgtcaaag aaacacctga     2520

gatgaattgg tgtgaacgaa ttttgcaagt ttaatttgat ttatttcaga gaaaatagaa     2580

aaaacaatgt tagaaggtta tttaaaatga tacttaaata aagaaagtgt gaggtctact     2640

ttaaaaaaat tcaaatgaag agaaaaagaa aaacagcatt ctagaaatgg catttctcct     2700

aattaatttt ccacttaatg gaagattatc aattgtccta ttttatgatc ccaggactga     2760

agacagttgt gggatatctg tcatatttat cctgtgagtc attgtgaata atgacataca     2820

gtactgaagt aatctgattt tattctttgg aaattcaatg cattggtcac actaataaca     2880

tcaacatctg ctatcactta tctttttaaa actaaccaaa aaaggccggg tgcagtggat     2940

cccagcactt tgggaggcca aggcgggtgg atcatctaag gtcaggattt cgagactagc     3000

ctggccaaca tggcaaaacc ctgtctctac taaaaaaaat acaaaaattt gccgggcgtg     3060

gtggcgtgtg cctgtagtcc cagttacttg ggaggctgag gtgggagaat tccttgaagc     3120

caggaggcgg aggttgcagt gagccaagat cacaccattg cactccagcc tgggtgacag     3180

agtgagactc cgtctcaaaa aaaaaaaaac aaaactggaa agttcagaaa cagaagttca     3240

cactaacaga gtatggtttt aattttcctt tgaatgaaaa ggatagaaga taaaattgtg     3300

tattgttaac atgtaaataa aattggagct aatttgaaac tagcttctca ataacttcat     3360

ctttctagag actcattacc tgtgggcttg tcaaacctgg actatttggc caaataggtt     3420

gctatagaga ttgcaagtgt tcctcctctt tatttttttc atattttttg agacggagtt     3480

tcactcttgt tgcccaggct ggattgcagt gtcacgatct cggctcactg caacctttgc     3540

ctcccatatt caagcagttc tcctgcctca acctcccaag tagctgggat tataggcgcc     3600

tgccaccaca cctagctaat ttttgtgttt ttagtagaga tggtttcatc atgttggccg     3660

ggctggtctc aaactcctga cctcaggtga tccacccgcc ttggctgccc aaagtgctgg     3720

gattacaggc atgagccact gcacccaact cctctttcgt ctttctttaa cacacactag     3780

gctctttgtg tattatgatt cagtgctatt tgtaactgtg tcccagtgac caaattgcac     3840

tcgactcgat cagctgttca tccatttcgt gttttttcct gtcaaacatt aatccagcaa     3900

atatatgagg tatttaccaa tttattttct tagtattaca aaataattca ttagcataaa     3960

gtacaatagt gaaatatttg agttgttcgg aacctcaatt aatcctgttt tacatttcag     4020

acctaaagct ggcaatcagg agaagaagca ctttgtttta aatgtggaga agataacact     4080

tgattccatt tcattgtcat tagtgtatta accagcagga gaggtgatga gccatttttc     4140

aaatgaaata ccttttattt ccatataatt tttttatttt agagttcaat agctgtttct     4200

atgattatcc tcaatttcca tatgttactg aatctgaaaa acatctttaa aattcaaaca     4260

gttccatttt ctctcttgta agtgttaaat gtgataaaag tacatatttt aaattgtttt     4320

cagctcttgg atatagcagc aataaaaaca ctaatttgtg ggtatttaag aaaacctgga     4380

gaataaactc atactttaaa agatca                                          4406


<210> 1376
<211> 1321
<212> DNA
<213> Homo sapiens

<400> 1376
gggttgggca ggcctactga ctgctgcctg aaggttgctg taaagggact aagtaaatca       60

attaactcca cagttttcac aaaggtctct tgatatcaaa acttctttcc ttgcatgctt      120

ctctgatcct gtggagatga aaattgacat ccatagtcat attctaccaa aagaatggcc      180

agatctaaaa aagaggtttg gctacggagg ctgggtgcag ctccaacacc acagcaaggg      240

agaagcaaag ttgttgaaag atgggaaagt cttcagagtg gtgcgagaga attgctggga      300

tccagaagtt cgtattagag aaatggacca aaaaggagta acagtgcaag ccctttccac      360

agttcctgtc atgtttagct actgggccaa acctgaggac actttaaacc tgtgccagct      420

tttaaacaac gaccttgcca gcaccgttgt gagctacccc aggaggttcg tgggtctggg      480

gacgttgccc atgcaggccc ctgagctggc ggtcaaggag atggagcgct gtgtgaaaga      540

gctgggcttt cccggggtcc aaattggcac ccacgtcaac gagtgggacc tgaacgcgca      600

ggagctcttt cctgtctatg cggcagccga aaggctgaag tgttccctgt tcgtgcatcc      660

ctgggacatg cagatggatg gacgaatggc caaatactgg ctcccttggc ttgtaggaat      720

gccagcagag accaccatag ccatttgctc catgatcatg ggtggagtat ttgagaagtt      780

tcccaaactg aaagtgtgtt tcgcacatgg tggtggtgcc ttccccttca cagtgggaag      840

aatctcccat ggattcagca tgcgcccaga tctgtgtgcc caggacaacc ccatgaaccc      900

gaagaaatac cttggttcct tttacacaga tgctttggtt catgatcctc tgtccctcaa      960

gctgttaaca gatgtcatag gaaaggataa agtcattttg ggaaccgatt acccctttcc     1020

actaggtgag ctggaacctg ggaaactaat agagtccatg gaagaatttg atgaagaaac     1080

aaagaataaa ctcaaagccg gcaatgccct ggcatttttg ggtcttgaga gaaaacaatt     1140

tgaatgactg aatttactac aaaggcaaac tttcaaaagg atatctcatt tttgtttcta     1200

aatatgtatc aacaggtatc aacaaaatcc tattttgaac tattttactc agaaatgaat     1260

gtcccaaata tcctaaatta ttcataataa aaatgatttg taagtgtttt cattctgaaa     1320

a                                                                     1321


<210> 1377
<211> 2903
<212> DNA
<213> Homo sapiens

<400> 1377
agtaactgac tacttttctc ccttctctag ggtcctagca cagtgtctga tggagctttc       60

ctaccagacc ctgaaattca cgcatcaggc gcgggaagcg tgcgagatga ggacagaagc      120

acgacgaaaa aatcttctca ttttgatttc gcattattta acacaagaag ggtatatcga      180

tacagcaaat gctttggagc aagaaactaa actggggtta cgacggtttg aagtttgtga      240

caacattgat cttgaaacta ttttgatgga atatgagagt tattattttg taaaatttca      300

gaaatacccc aaaattgtca aaaagtcatc agacacagca gaaaataatt taccgcaaag      360

aagtagaggg aagaccagaa ggatgatgaa cgacagttgt caaaatcttc ccaagatcaa      420

tcagcagagg ccccggtcca aaaccacagc ggggaagaca ggggacacca aatcgctcaa      480

taaggagcat cctaatcagg aggtagttga taacactcgc ctggaaagtg ccaacttcgg      540

cctacatata tcaagaatcc gtaaagacag tggagaggaa aatgcccacc cacgaagagg      600

ccaaatcatt gacttccaag ggctgctcac agatgccatc aagggagcaa ccagtgaact      660

tgccttgaac accttcgacc ataatccaga cccctcagaa cgactgctga aacctctgag      720

tgcatttatt ggcatgaaca gtgagatgcg agaattggca gccgtggtga gccgggacat      780

ttatctccat aatccaaaca taaagtggaa tgacattatt ggacttgatg cagccaagca      840

gttagtcaaa gaagctgttg tgtatcctat aaggtatcca cagctattta caggaattct      900

ttctccctgg aaaggactac tgctgtacgg ccctccaggt acaggaaaga ctttactggc      960

caaagctgtg gccactgaat gtaaaacaac cttctttaac atttctgcat ccaccattgt     1020

cagcaaatgg agaggggatt cagaaaaact cgttcgggtg ttatttgagc ttgcccgcta     1080

ccacgcccca tccacgatct tcctggacga gctggagtcg gtgatgagtc agagaggcac     1140

agcttctggg ggagaacatg aaggaagcct gcggatgaag acagagttac tggtgcagat     1200

ggatgggctg gcacgctcag aagatctcgt atttgtctta gcagcttcta acctgccgtg     1260

ggagctggac tgtgccatgt tacgccgcct ggagaagagg attctggtcg atctccccag     1320

ccgggaggcc aggcaggcca tgatctacca ctggctgcct cctgtgagca agagcagggc     1380

cttggagctg cacacagagc tggagtacag tgtgctgagc caggagactg agggctactc     1440

aggctcagat attaagctcg tctgcaggga agcagccatg cggcccgtga ggaagatctt     1500

tgatgcactt gaaaatcacc agtcagaaag cagcgactta cccaggatcc agttggatat     1560

agtaaccact gccgactttc tggatgtgct aactcacacc aagccctccg caaagaatct     1620

ggctcagaga tactcagact ggcaaagaga gttcgagtct gtctgaaacc acatttaccc     1680

tgacctggcc acaaaggcaa ccacaaagac ctcctagttt attaatgtcc gtgggagaac     1740

aaaatgattg gaatggaaaa gagaaaatta tttttgaaga ctggattaac ttgagccact     1800

gtattgtttt ggatagctga gatatattta ttaacttacc attatcgatg tcagcaaaat     1860

attgagagtt tcagttacat acatatatgt gctattgggt catacaatgg agatttttct     1920

gacaattaga ctccataaaa ttttaatgaa caattttctg taatgttact catttgtaaa     1980

ctttttaaga aaaagatgta cttagaaaag ttgtgttggc cacacacagg atgaccctga     2040

gttggggcag ccaagtagaa gctaagcttg acaggcactg cccagctgac agtcccaggg     2100

tgaaggagga cggaagcagg gaaggcaatg cagtctgttt ctcattccgg acaatattct     2160

gaatctcatc agctccccct aattctgact ccatccagct ttgtcagcag caaacccctc     2220

ccaaactaag ccccactcag aaatgtcact gagcattctg atgctagagc taatagccag     2280

ggtgactagc acaccatcac catcagctgc cagtctgatt gttttgggtt ctggccccca     2340

ataacatctt ttcactcttc acacctcaca tccggtgtgc tctgcccttc tctttccatt     2400

gccgcagctt ctcatcagat ccaaagctta ggatggggca cctaagcttc gagaacattc     2460

atcccaagtc ttccctgctc ttaggctctt ccccctctcc ttaaggggtt ataaacaact     2520

agacgcatct ctctcagaaa cccacaatcc gaggcatcta ctttcaaccc ttgataaatt     2580

ttgaaggctt ctactaagta atgccacttc ttttccccca ctagaactta cctatgggaa     2640

atcaccttct tttctcttcc ttgccttgtc ttcatcatcc ctgcagacag actcttcaag     2700

aggaaaaacc tccagaaaga gacactttgg atagctaagt atcccaaagg attttaccct     2760

tttaaacaaa accaaagcat ttttttcggt atcgattatt ttgagattat tctcaaatgc     2820

ctctttaaac atcatttcat ggaaaatgtc aaattgaaaa tataccttat ttaacaaatt     2880

gaaaataaaa aagatttcat ctc                                             2903


<210> 1378
<211> 1400
<212> DNA
<213> Homo sapiens

<400> 1378
gtaactgtcc ggccgcggcg ctggcttaag ccatggctga gggtagccgg attcctcagg       60

cccgggcgct cctacagcag tgcctgcacg cccggctgca aattcgccca gccgatgggg      120

acgtcgcggc ccagtgggtg gaggtccaaa gaggactggt gatctacgtg tgctttttca      180

agggagctga taaagaactt cttcccaaaa tggttaatac actgttaaat gtgaaattaa      240

gtgagacaga aaatggcaag catgtctcta tattggatct acctggcaac attcttatta      300

tccctcaagc tacccttgga ggaagactaa aaggaagaaa catgcaatat cactctaact      360

ctggaaaaga agaagggttt gaactttact ctcaatttgt gactctatgt gaaaaagaag      420

tagctgctaa tagcaagtgt gctgaagcta gggttgtagt ggaacatggc acttatggga      480

acaggcaggt gttaaagctg gacaccaacg gaccattcac acacttaatt gagttttgaa      540

aatgaaaaac tagtttctat agctgttttc tggtatgaaa tgatctaaag tataattaga      600

ttttcttccc cttaatcttg aatatactaa tcttcagcat ttttagacag gaaaatcttg      660

ggtttcatat ataactctgc acctgctaat tggatgactt tgccaagtca cctaaactct      720

ggatctcagt caccttttgt cctacattcc tctacccttc tacttgaaaa tttgaaatat      780

gctgtctatt cacttcatag tcattaagga aatgttctta attgtttttt tgtttttgtt      840

ttttttttga gatggagtct tgctctgtcg ccagactgga gtgcagtggc gcaatctcgg      900

ctcactgcaa cctccacctc ctggattcaa gcgattctcc tgcctcagcc tcccaagtag      960

ctgggactac aggcatgagc caccgtgccc ggcctcttag ttgtttttta aaaattatgt     1020

acattttaag tattttgcaa tgaagaaatt catgcaaaca agaaaaacac atttcttata     1080

ccatcaaatt tgtgtagcat gtaataaaaa taactatttg tattaaaatt aggtaaactt     1140

cagcactttg ggaggccgag gtgggaggat cacttgagcc caggagtttg cgaccagcct     1200

gggcagaata gcaagaccca gtctctaaca tatacatata catatagata tatatgtaat     1260

atagaagggt tattgtgtgt tatattactt tccagggaca ttcaaatgtt ttacattact     1320

ttaagaatct ttacttgata taagaacaaa gtataagggt ttaaaagttg tttttattaa     1380

acatactata taaatgggtt                                                 1400


<210> 1379
<211> 3060
<212> DNA
<213> Homo sapiens

<400> 1379
gaacaaatca aatcgaagca aagaaactgc cggctttcaa aatcctcctc ctccgccatc       60

atccgccgcg gtgcggagag caggtggtgc tggaagcgcg tgaggccggg agctcgagag      120

agctaacaga ctagccggct ggacatctgg accgctggat ccggaggtgg cgaccccggc      180

ctgacccgga ccctaaatcc gtccccgccc cagagggcgg aggcgcgcgc tcgattcccc      240

ccacgcggcg gcgccgcctg tttacgtctg cagatctcca ggggagccca ccagcctagt      300

caacatggcc tcggaagaca ttgccaagct ggcagagaca cttgccaaga ctcaggtggc      360

cgggggacag ctgagtttca aaggcaagag cctcaaactc aacactgcag aagatgctaa      420

agatgtgatt aaagagattg aagactttga cagcttggag gctctgcgtc tggaaggcaa      480

cacagtgggc gtggaagcag ccagggtcat cgccaaggcc ttagagaaga agtcggagtt      540

gaagcgctgc cactggagtg acatgttcac gggaaggctg cggaccgaga tcccaccagc      600

cctgatctca ctaggggaag gactcatcac agctggggct cagctggtgg agctggactt      660

aagcgacaac gcattcgggc ccgacggtgt gcaaggcttc gaggccctgc tcaagagctc      720

agcctgcttc accctgcagg aactcaagct caacaactgt ggcatgggca ttggcggcgg      780

caagatcctg gctgcagctc tgaccgaatg tcaccggaaa tccagtgccc aaggcaagcc      840

tctggccctg aaggtctttg tggctggcag aaaccgtctg gagaatgatg gcgccactgc      900

cttggcagaa gcttttaggg tcatcgggac cctggaggag gtccacatgc cacagaatgg      960

gatcaaccac cctggcatca ctgccctggc ccaggctttc gctgtcaacc ccctgctgcg     1020

ggtcatcaac ctgaatgaca acaccttcac tgagaagggc gccgtggcca tggccgagac     1080

cttgaagacc ttgcggcagg tggaggtgat taattttggg gactgcctgg tgcgctccaa     1140

gggtgcagtt gccattgcag atgccatccg cggcggcctg cccaagctaa aggagctgaa     1200

cttgtcattc tgtgaaatca agagggatgc tgccctggct gttgctgagg ccatggcaga     1260

caaagctgag ctggagaagc tggacctgaa tggcaacacc ctgggagaag aaggctgtga     1320

acagcttcag gaggtgctgg agggcttcaa catggccaag gtgctggcgt ccctcagtga     1380

tgacgaggac gaggaggagg aggaggaagg agaagaggaa gaagaggaag cagaagaaga     1440

ggaggaggaa gatgaggaag aggaggaaga agaggaggag gaggaggaag aagagcctca     1500

gcagcgaggg cagggagaga agtcagccac gccctcacgg aagattctgg accctaacac     1560

tggggagcca gctcccgtgc tgtcctcccc acctcctgca gacgtctcca ccttcctggc     1620

ttttccctct ccagagaagc tgctgcgcct agggcccaag agctccgtgc tgatagccca     1680

gcagactgac acgtctgacc ccgagaaggt ggtctctgcc ttcctaaagg tgtcatctgt     1740

gttcaaggac gaagctactg tgaggatggc agtgcaggat gcagtagatg ccctgatgca     1800

gaaggctttc aactcctcgt ccttcaactc caacaccttc ctcaccaggc tgctcgtgca     1860

catgggtctg ctcaagagtg aagacaaggt caaggccatt gccaacctgt acggccccct     1920

gatggcgctg aaccacatgg tgcagcagga ctatttcccc aaggcccttg cacccctgct     1980

gctggcgttc gtgaccaagc ccaacagcgc cctggaatcc tgctccttcg cccgccacag     2040

tctgctgcag acgctgtaca aggtctagac tcaaagcctc tcccatccct tggcctggac     2100

cagtgagctg gggagggact cggatgaact gaggcgcagc ctacgccatt gccttggaca     2160

ggactctggc cacaggcagg gcgggtctgt gtcccatgtg tcctgtcagt cccctgagta     2220

tgtgtgtggg tgtggcgcat gtgcaggtct gtgcctcctg tcgggatttg ggttttaacg     2280

tcttctgctg gcccagccct gctctgttgt ggggagttgg cccccagggg aaagggctgt     2340

gagctgctcc gccattaaac tcacctccac ctgagggcgc tctgctgatc tccgcctggg     2400

ccctgatggc cgtccccacc cacctgcctt ccggcccggc tccctggcgg agccagaacc     2460

cagggagttg cccgcgtgct gtccttcccc tctgtgttgt gattgggttg tttcctgccc     2520

tgcctggggc tgcttctcgt caccaagccc tggtcctgcg gcagctgtca cccctaccat     2580

ccataccact gtgctgaccg ctcagcctga agagcagaga atgccatggg tgggactgtg     2640

ggggtcggat cgtggggttg ttggcagagg gcaaccctgg gccccacacc gtgtggacag     2700

gcagacacca gattgtccag gagcaggagc tgctgggact gcgctggccc cggacctagt     2760

gggccttctc ctggctgctg agatgtcgtc tgtgactggc ctggctggag ggggagtgtt     2820

gacaacccaa agctgttctc cagtctgggg agggagaggc agggtcccca atgtccgagc     2880

tgcatctgga cgctgctctt aaaggacctc ctggggcagg ggagcggtag ggtctggact     2940

gggcagatgc tgtatgacct ccctgagcac ccgtgactgc cccatgcttt cccctttgtg     3000

ctctgtgtgt gtctgggctg tgcccggggg cttcacaaat aaagtcgtgt ggcagcttca     3060


<210> 1380
<211> 2745
<212> DNA
<213> Homo sapiens

<400> 1380
ttgtacaggt agccaggtgt cggtctccag cctgagaact ctggctgttg ttccttgtgt       60

cgtcccatat tcctgcctgg cctgcgatgg acatcagcaa gggcctccca ggcatgcagg      120

gaggcctcca catatggatc tctgagaacc ggaagatggt gccggtaccc gagggggctt      180

acgggaactt ttttgaggaa cactgctatg tcatcctcca cgtcccccag agcccgaagg      240

ccacgcaggg ggcgtccagc gacctgcact actgggtcgg gaagcaggcg ggtgcggaag      300

cgcagggcgc tgcggaggcc ttccagcagc gcctacagga cgagctgggg ggccagaccg      360

tgctgcaccg cgaggcgcag ggccacgagt ccgactgctt ctgcagctac ttccgcccgg      420

gaatcatcta caggaaggga ggcctagcat ctgacctcaa gcatgtggag accaacttgt      480

tcaacatcca gcgactgctg cacatcaaag ggaggaagca cgtgtctgcc actgaggtgg      540

agctctcctg gaacagcttt aataagggtg acatcttcct gctggaccta ggcaagatga      600

tgattcagtg gaatgggccc aagaccagca tttctgagaa ggctcggggg ctggctttga      660

cctacagcct ccgggacagg gaacgtggtg gtggtcgtgc acagattggt gtggtggatg      720

atgaggccaa agccccggac ctcatgcaga tcatggaggc tgtgctgggc cgcagggtgg      780

gcagcctgcg tgccgccacg cccagcaagg atatcaacca gctgcagaag gccaatgttc      840

gcctgtacca tgtctatgag aagggcaaag acctgctgca ggaggaggac ttctacatcc      900

tggaccaggg tggcttcaag atctatgtgt ggcagggacg catgtctagc ctccaggaga      960

gaaaggctgc cttcagccgg gctgtgggct tcatccaggc caagggctac ccgacctaca     1020

ccaacgtgga ggtggtgaac gacggcgccg agtcggccgc gttcaagcag ctcttccgga     1080

cttggtctga gaagcggcgc aggaaccaga agctcggcgg gagggataaa tcgattcatg     1140

taaagctgga cgtgggcaag ctgcacaccc agcctaagtt agcggcccag ctcaggatgg     1200

tggacgacgg ctctgggaag gtggaggtgt ggtgcatcca ggacttacac aggcagcccg     1260

tggaccccaa gcgtcatgga cagctgtgtg caggcaactg ctaccttgtg ctctacacat     1320

accagaggct gggccgtgtc cagtacatcc tgtacctatg gcagggccac caggccactg     1380

cggatgagat tgaggccctg aacagcaacg ctgaggaact agatgtcatg tatggtggcg     1440

tcctagtaca ggagcatgtg accatgggca gcgagccccc ccacttcctc gccatcttcc     1500

agggccagct ggtgatcttc caggagagag ctgggcacca tggaaagggg cagtcagcat     1560

ccaccacaag gcttttccaa gtgcaaggca ctgacagcca caacaccagg accatggagg     1620

tgccagcccg tgcctcatcc ctcaactcca gtgacatctt cttgctggtc acagccagcg     1680

tctgctacct ctggtttggg aagggctgta atggtgatca gcgtgagatg gcacgggtgg     1740

tggtcactgt catttccagg aagaatgagg aaacggtgct ggagggtcag gagcctcccc     1800

acttctggga ggccctggga ggccgggccc cctaccccag caacaagagg ctccctgagg     1860

aggtccccag cttccagcca cgactgtttg agtgctccag ccacatgggc tgcctggtcc     1920

tcgcagaagt ggggttcttc agccaggagg acctggacaa gtatgacatc atgttactgg     1980

acacctggca ggagatcttc ctgtggcttg gggaagctgc aagtgagtgg aaggaggcgg     2040

tggcctgggg ccaggagtac ctgaagactc acccagcagg gaggagcccg gccacaccca     2100

tcgtgctggt caagcagggc catgagcctc ccaccttcat tggatggttc ttcacttggg     2160

acccctacaa gtggactagc cacccgtccc acaaggaagt ggtggatggc agcccggcag     2220

cagcatcaac catctctgag ataacagcag aagtcaacaa cttgcggcta tccagatggc     2280

cgggcaatgg cagggcaggt gccgtggccc tgcaggccct caagggctcc caggacagct     2340

cagagaatga tctggtgcga agccccaagt cggctggcag cagaaccagc agctccgtca     2400

gcagcaccag cgccacgatc aacgggggcc tgcgccggga acaactgatg caccaggctg     2460

ttgaggacct gccagagggc gtggaccctg cccgcaggga gttctatctc tcagactctg     2520

acttccaaga tatctttggg aaatccaagg aggaattcta cagcatggcc acgtggaggc     2580

agcggcagga gaaaaagcag ctgggcttct tctgaaccca agccctctcg actgccccta     2640

tcccctggac cccaacatac ctacaatgct ggggaggccc tgcttccact cccctcagag     2700

gcttttggtc atcctctgcg tgtcagtaaa agcaggcagc ccata                     2745


<210> 1381
<211> 2157
<212> DNA
<213> Homo sapiens

<400> 1381
ggccgccatc ttggattgcg aactgggtcg ctacgcttca cgccaggggc ggagtggcgg       60

cccttctgtt acccgccaca cacgtcgccg ctggggactg ggaaatcagg gcatcggaga      120

gtgccacatt aatggatgcc atggctagtc cagggaaaga taactataga atgaaaagtt      180

ataagaataa agccctaaat cctcaagaga tgcgtagacg aagagaagaa gaaggaatac      240

agcttagaaa acaaaaaaga gaagaacagt tgttcaaacg cagaaatgtc tatttgccca      300

gaaatgatga atctatgctt gaaagtccta tacaggatcc agatattagt tccactgtac      360

ccattccaga ggaagaagtt gttactacag atatggttca gatgattttt tctaataatg      420

ctgatcaaca gctaacagca acacagaaat ttagaaagct gctttctaaa gaacctaatc      480

caccaataga tcaagttata cagaaaccag gagttgtaca gagatttgtg aaatttcttg      540

aaagaaatga aaattgcact ttacaatttg aagctgcatg ggcattaaca aatatagcat      600

ctggaacttt tctgcatacc aaggtagtga ttgaaactgg ggctgttccg atttttatca      660

aacttcttaa ttctgaacat gaagatgttc aggaacaggc tgtttgggca cttggtaata      720

ttgctggtga caatgcagaa tgcagagatt ttgttttgaa ttgtgaaata cttccacctc      780

ttttagagtt attaacaaat tcaaacagac tcacaacaac aagaaatgcc gtgtgggccc      840

tctcaaattt atgtagaggc aaaaaccctc ctccaaactt tagtaaggtt tcaccttgct      900

taaatgtcct gtcacgactg ttgtttagca gtgacccaga tgtgttagca gacgtgtgtt      960

gggccctttc ttatctctcc gatggaccca atgataaaat tcaagcagtc attgattctg     1020

gagtctgtcg aagattggtg gaacttttga tgcacaatga ttataaagtt gtatcacctg     1080

cattaagggc agttggtaat attgtgactg gtgatgatat tcaaacacag gtaattttga     1140

attgttctgc attaccctgt ctcttacatt tattgagtag cccaaaggag tcaattagaa     1200

aagaagcctg ctggactgtt tctaacatca ctgctggaaa tagagctcag attcaggctg     1260

ttatagatgc aaatattttt cctgttttga ttgagattct tcagaaagca gagtttcgta     1320

ccagaaaaga agcagcttgg gctataacta atgcaacatc aggaggtact ccagagcaaa     1380

taaggtattt ggtagcttta ggctgcatta aaccactttg tgatcttttg actgttatgg     1440

actccaaaat agtccaagtg gctttaaatg gacttgaaaa tattttacgt cttggagaac     1500

aagaatctaa gcagaatgga ataggcatta atccatactg tgctctcatt gaagaagcat     1560

atggtctgga taaaattgag tttttgcaaa gccatgaaaa tcaggaaatt taccagaagg     1620

catttgatct gattgaacat tactttggtg tagaagaaga tgaccccagc attgtacctc     1680

aggtggatga aaaccaacaa cagtttatat ttcagcagca ggaagcacca atggatggat     1740

ttcaacttta acttactgga ggaaaaaaaa tttatggcta aaaagggtag cttcagaaat     1800

gacagacttt ttcattgaat gatgaggaca cagcagccat attatgccaa gaggaaaaat     1860

atcatgatca tattgaaaga tcaagcatga gcttccatgg tgaagtcttc tgtaccaatg     1920

caccagagaa tgcctaccat ccaaaaaagc agtcagctga tggaaaagaa gattattaaa     1980

cctttgttct gggatttact gttaaaaaac aaacaaaaaa caacaaaaaa gcggtgacag     2040

gaaacagtta aggaaatgat ttaactgaag ggaagcaaga tttttttaaa gcattgttct     2100

taatccccat gactgtcctt cagtcacaat tccagaataa aagaatctac tttgtgt        2157


<210> 1382
<211> 4225
<212> DNA
<213> Homo sapiens

<400> 1382
agggactgca ggggcgccgg cgggcggatc gagaggaagg tcggggccat gggccggcac       60

tgcgcctcgg gagggtccgg ccaccgctgg aacccgaggc cggggctggg ggcgctccgg      120

gctccgaccc acgggccggc cggccctgcc cgggctgggt gaggggcgcc cgcctcaagc      180

tagaggagga gcggaggccg cgcgcggccc gccgagcgcc ttcaggatgc tcatcaagga      240

ataccacatt ctgctgccca tgagcctgga cgagtaccag gtggcccagc tctacatgat      300

ccagaaaaag agccgggagg agtctagtgg tgagggcagc ggcgtggaga tcctggccaa      360

ccggccctac acggatgggc ccgggggcag cgggcaatac acacacaagg tgtaccacgt      420

gggctcccac atcccaggct ggttccgggc actgctgccc aaggctgccc tgcaggtaga      480

agaggaatcc tggaatgcct acccctacac ccgaacccgg tacacctgcc ctttcgtgga      540

gaaattctcc attgaaattg agacctatta cctgcctgat ggggggcagc agccaaacgt      600

cttcaacctg agcggggccg agaggagaca gcgcatcctg gacaccatcg acatcgtgcg      660

ggatgcagtg gccccaggcg agtacaaagc agaagaggac ccccggcttt atcactcggt      720

caagacgggc cgagggccac tgtctgatga ctgggcacgg acggcggcac agacggggcc      780

ccttatgtgt gcctataagc tgtgcaaggt tgagttccgc tactggggca tgcaagccaa      840

gatcgagcag ttcatccatg atgtaggtct gcgtcgggtg atgctgcggg cccaccgcca      900

ggcctggtgc tggcaggatg agtggacaga gctgagcatg gctgacatcc gggcactgga      960

agaggagact gctcgcatgc tggcccagcg catggccaag tgcaacacag gcagtgaggg     1020

gtccgaggcc cagccccccg ggaaaccgag caccgaggcc cggtctgcgg ccagcaacac     1080

tggcaccccc gatgggcctg aggccccccc aggcccagat gcctcccccg atgccagctt     1140

tgggaagcag tggtcctcat cctcccgttc ctcctactca tcccaacatg gaggggctgt     1200

gtctccccag agcttgtctg agtggcgcat gcagaacatt gcccgagact ctgagaacag     1260

ctccgaggaa gagttctttg atgcccacga aggcttctcg gacagtgagg aggtcttccc     1320

caaggagatg accaagtgga actccaatga cttcattgat gcctttgcct ccccagtgga     1380

ggcagaggga acgccagagc ctggagccga ggcagctaaa ggcattgagg atggggccca     1440

agcacccagg gactcagagg gcctggatgg agccggggag ctgggggctg aggcatgcgc     1500

agtccacgcc ctcttcctta tcctgcacag cggcaacatc ctggactcag gccctggaga     1560

cgccaactcc aagcaggcgg atgtgcagac gctgagctcc gccttcgagg ccgtcacccg     1620

catccacttc cctgaggcct tgggccacgt ggcgctgcga ctggtgccct gtccacccat     1680

ctgcgccgcc gcctatgccc ttgtctccaa cctgagccct tacagccacg atggggacag     1740

cctgtctcgc tcccaagacc acattccact ggctgccctg ccactgctgg ccacctcatc     1800

ctcccgctac cagggcgccg tggccaccgt cattgcccgc accaaccagg cctactcagc     1860

cttcctgcgc tcacctgagg gtgccggctt ctgtgggcag gtcgcactga ttggagatgg     1920

tgttggtggc atcctgggct ttgatgcact ctgccacagt gctaacgcgg gcaccgggag     1980

tcggggcagc agccgccgtg ggagcatgaa caatgagctg ctctctccgg agtttggccc     2040

agtgcgggac cccctggcag atggtgtgga aggcctgggt cggggcagcc cagaaccctc     2100

ggccttgcct ccccagcgca tccccagcga catggccagt cctgagcccg agggctctca     2160

gaacagcctt caggcagccc ccgcaaccac ctcctcctgg gagccccggc gggcaagcac     2220

ggccttctgc ccacccgctg ccagttccga ggcacctgac ggccccagca gcactgcccg     2280

ccttgacttc aaggtctctg gcttcttcct cttcggctcc ccactgggcc tggtgctggc     2340

tctgcgcaaa actgtgatgc ccgccctgga ggcagcccag atgcgcccag cctgtgaaca     2400

gatctacaac ctcttccacg cggctgaccc ctgcgcctca cgcctcgagc ccctgctggc     2460

cccgaagttc caggccatcg ccccactgac cgtgccccgc taccagaagt tccccctggg     2520

agatggctca tccctgctgc tggccgacac tctgcagacg cactccagcc tctttctgga     2580

ggagctggag atgctggtgc cctcaacacc cacctctact agcggtgcct tctggaaggg     2640

cagtgagttg gccactgacc ccccggccca gccagccgcc cccagcacca ccagtgaggt     2700

ggttaagatc ctggagcgct ggtgggggac caagcggatc gactactcgc tgtactgccc     2760

cgaggcgctc accgcctttc ccaccgtcac gctgccccac ctcttccacg ccagctactg     2820

ggagtccgcc gacgtggtgg cgttcatcct gcgccaggtg atcgagaagg agcggccaca     2880

gctggcggaa tgcgaggagc cgtccatcta cagcccggcc ttccccaggg agaagtggca     2940

gcgaaaacgc acgcaggtca agatccggaa cgtcacttcc aaccaccggg cgagcgacac     3000

ggtggtgtgc gagggccgcc cccaggtgct aagcgggcgc ttcatgtacg ggcccctgga     3060

cgtcgtcacg ctcactggag agaaggtgga tgtctacatc atgacgcagc cgctgtcggg     3120

caagtggatc cactttggca ccgaagtcac caatagctcg ggccgcctca ccttcccagt     3180

tcccccagaa cgcgcgctgg gcattggtgt ctaccccgtg cgcatggtgg tcaggggcga     3240

ccacacctat gccgaatgct gcctgactgt ggtggcccgc ggcacggagg ctgtggtctt     3300

cagcatcgac ggctccttca ccgccagcgt ctccatcatg ggcagcgacc ccaaggtgcg     3360

agctggcgcc gtggacgtgg tcaggcactg gcaggactcc ggctacctga tcgtgtatgt     3420

cacaggccgg ccggatatgc agaagcaccg cgtggtggca tggctgtcgc agcacaactt     3480

cccccacggc gtcgtctcct tctgcgacgg cctcacccac gacccactac gccagaaggc     3540

aatgtttctg cagagcctgg tgcaggaggt agaactgaac atcgtggccg gttatgggtc     3600

tcccaaagat gtggctgtat acgcggcgct ggggctgtcc ccgagccaga cctacatcgt     3660

gggccgtgcc gtgcggaagc tacaggcgca gtgccagttc ctgtcagacg gctatgtggc     3720

ccacctgggc cagctggaag cgggctcgca ctcgcatgcc tcctcgggac ccccgagagc     3780

tgccttgggc aagagcagct atggtgtggc tgcccccgtg gacttcctgc gcaaacagag     3840

ccagctgctt cgctcgaggg gccccagcca ggcggagcgt gagggcccgg gaacaccacc     3900

caccaccctg gcacggggca aagcacggag catcagcctg aagctggaca gcgaggagtg     3960

aggcccacac cagcctggac ctgggttatt tattgacaca cccaaggggc ccgaggggct     4020

gcgtgtggga ggctggggac ccagactttt ggccccagcg ctggcccccc cagccccaca     4080

ccctatatct ccgtgtgctc ctcggtgtta cttccctttc atatgagggg acccagcgcc     4140

ggggggaggg aggagggcgt gggcatgggc gcagaggctt ttccagtgtg tataaatcca     4200

tgaaaataaa cgccacctgc acccc                                           4225


<210> 1383
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 1383
gcggcggcgg cagcggcagc ggcagcggcg ctgagttttg tctcccgggc cgtctgggcg       60

cgcgcgggtg tcccagaatg aaatatgact gaggactctc agagaaactt tcgttcagta      120

tattatgaga aagtggggtt tcgtggagtt gaagaaaaga aatcattaga aattctccta      180

aaagatgacc gtctggatac tgagaaactt tgtactttta gtcagaggtt ccctctcccg      240

tccatgtacc gtgcattggt atggaaggtg cttctaggaa tcttgcctcc acaccacgag      300

tcccatgcca aggtgatgat gtatcgtaag gagcagtact tggatgtcct tcatgccctg      360

aaagtcgttc gctttgttag tgatgccaca cctcaggctg aagtctatct ccgcatgtat      420

cagctggagt ctgggaagtt acctcgaagt ccctcttttc cactggagcc agatgatgaa      480

gtgtttcttg ccatagctaa agccatggag gaaatggtgg aagatagtgt cgactgttac      540

tggatcaccc gacgctttgt gaaccaatta aataccaagt accgggattc cttgccccag      600

ttgccaaaag cgtttgaaca atacttgaat ctggaagatg gcagactgct gactcatctg      660

aggatgtgtt ccgcggcgcc caaacttcct tatgatctct ggttcaagag gtgctttgcg      720

ggatgtttgc ctgaatccag tttacagagg gtttgggata aagttgtgag tggatcctgt      780

aagatcctag tttttgtagc tgtcgaaatt ttattaacct ttaaaataaa agttatggca      840

ctgaacagtg cagagaagat aacaaagttt ctggaaaata ttccccagga cagctcagac      900

gcgatcgtga gcaaggccat tgacttgtgg cacaaacact gtgggacccc ggtccattca      960

agctgaacgc acccgctggt tgtggaccgt ctgccaggca ccacagtgag cattgtgttc     1020

ttggcatgtg atctgggaaa ctgattgaat aatacacttt tcttgctttg gtgctcaaag     1080

tggttttttt cccccaataa aattatttaa ttgaaa                               1116


<210> 1384
<211> 585
<212> DNA
<213> Homo sapiens

<400> 1384
gtgtagagaa gggatggata gtgaatgcca aggttagttc tagctggata aattagccaa       60

gggtttcagc tggataagtt ggctgagggt gctacaggtc tagccttaag gctgtctcac      120

tgaaacattt tggagtctgg agtcatctgt tctgaatagc gcccacatag tttatatttt      180

tttatttttt gagacagagt ctcactctgt tgcccaagct ggagtgcagt ggcacgatct      240

cagctcactg caacctctgc ctcccgggtt caagtgattc tcctgcctca gcctcctgag      300

tagctgggac tacagtgcag gcctgagtgt tccttccagc atgtcggagg gggagtccca      360

gacagtactt agcagtggct cagacccaaa ggtagaatcc tcatcttcag ctcctggcct      420

gacatcagtg tcacctcctg tgacctccac aacctcagct gcttccccag aggaagaaga      480

agaaagtgaa gatgagtctg agattttgga agagtcgccc tgtgggcgct ggcagaagag      540

gcgagaagag gtgaatcaac ggaatgtacc aggtattgac agtgc                      585


<210> 1385
<211> 5847
<212> DNA
<213> Homo sapiens

<400> 1385
ggcattatgc aattatatta ctaaggctgc tacctgccca tgcccctctc ctcctcctgg       60

tttggaacta ccctccccat ctgctgctat atttatctgc cttcttggcc ataaaaggct      120

ggttgtgtgg cctgacattc gactgcctga ccacatgcat tatttttgaa ctggccccca      180

gggtcctgtc tttagccctg cctcttaaca ttgtcttgga ttcaacctag gtggagtctt      240

cattctctca tccagctcct cggcctcatc ggaacatttc caccaccatt actcctttgg      300

aaactggtgg cccggttcct tcaaggggca caggatgtct ttgccttttt atcagaggtg      360

ccaccagcac tatgatctca gctaccgcaa caaggacgtg cgcagcaccg tgagtcacta      420

ccagcgggag aagaaacgct ccgccgtcta cacccagggc tccacggcct acagcagccg      480

ctcctccgcc gcgcaccgcc gggagtccga ggccttccgt cgggcgtccg cctcctcctc      540

ccagcagcag gcctcgcagc acgccctgag ctctgaagtc agtcggaagg cagcctcagc      600

ctacgattat ggctcctccc atggacttac agattccagt ctgctgttag atgattattc      660

atccaagttg agccccaaac caaagagagc caagcacagc ctactgtctg gagaagagaa      720

agaaaatttg cccagtgact acatggtacc cattttctca ggacgtcaaa agcatgtcag      780

tggaattact gatacggaag aagaaagaat taaagaagct gctgcttata tagcccagag      840

gaatcttctt gctagtgagg aaggaatcac aacatctaaa cagtccacgg catccaagca      900

gaccacggca tctaagcagt ccacggcatc caagcagtcc acagcatcca agcagtccac      960

ggcatccagg cagtccacgg catccaggca gtctgtggtt tccaaacagg ccacatccgc     1020

tcttcaacag gaagaaactt ctgaaaagaa gtcaaggaaa gttgtgattc gagaaaaggc     1080

agaacgcctg tccctgagga aaacattaga agaaaccgag acatatcatg ccaagctgaa     1140

tgaagaccat cttctccatg ctcctgagtt tatcattaaa cctcgctccc acacggtttg     1200

ggagaaggag aatgtaaaat tgcattgctc catagcaggc tggccagaac ctcgtgtcac     1260

gtggtataaa aaccaggtgc caataaatgt ccatgcaaac cctggaaagt atattattga     1320

gagtcgatat gggatgcaca ctctggagat taatggatgt gattttgaag atacagctca     1380

gtaccgggcc tcggcgatga atgttaaagg agagctttcg gcatatgctt cagttgtggt     1440

aaaaaggtat aagggagagt ttgatgagac tcgcttccac gctggggctt ccaccatgcc     1500

cctcagcttt ggtgtgaccc catatggtta tgcatcccgg tttgagatcc actttgatga     1560

caaatttgat gtgtcttttg ggagagaggg agagacaatg agtctaggct gtcgtgttgt     1620

catcactcct gaaattaaac atttccagcc agagatccag tggtacagaa acggagtacc     1680

tctttctcca tcaaaatggg tgcaaacact ttggagtgga gagcgggcaa cgctgacatt     1740

ttcccatctc aacaaagaag atgaaggcct ctatacaatc cgtgtacgga tgggagaata     1800

ttatgaacaa tatagtgctt atgtctttgt tcgagatgct gatgcagaga ttgaaggagc     1860

cccagctgct cccttggatg tgaagtgctt ggaggccaac aaagattata tcatcatctc     1920

ctggaaacag ccagctgtcg atggagggag tcctattctc ggatatttta ttgataagtg     1980

tgaggtgggc acagatagct ggtcgcagtg caatgacaca cctgtgaagt ttgctcgttt     2040

tcctgtcact ggattgatcg aaggtcgttc ctatatcttc cgagttcgag ctgtgaataa     2100

aatgggaata ggtttcccat ctcgagtttc cgagcccgtg gctgctctgg atccggctga     2160

gaaagctaga cttaaaagtc gcccctcagc accctggact ggacagatca ttgttactga     2220

agaggaacct tcagagggta ttgtgcctgg ccccccgaca gacctctctg tcactgaggc     2280

cacccggagc tatgtggtgc tcagctggaa gccccctggc cagcgtggtc atgagggcat     2340

tatgtacttt gtggaaaagt gtgaggcagg aacagaaaac tggcagcgag tgaacacgga     2400

gctccctgtg aagtctcccc gctttgctct gtttgacttg gccgagggga aatcctactg     2460

tttccgtgtc cgctgttcta attctgcagg agttggtgag ccctcagagg caacggaggt     2520

gactgtggta ggggacaaac ttgatatccc caaggctcct ggcaaaatca tcccaagcag     2580

aaacacagac acctcagtgg tagtttcgtg ggaggagtcc aaagatgcca aagagctggt     2640

cgggtactac atagaggcga gcgttgctgg ctctggcaag tgggagccct gtaacaacaa     2700

ccccgtgaag ggctcacgat tcacttgtca tggattagtg actggtcaga gttatatttt     2760

ccgggtcaga gcagtcaatg cagctggact tagtgaatat tcccaggatt cagaagctat     2820

tgaagtcaaa gctgctattg ggggaggagt gtctccagat gtgtgtcccg cactgagcga     2880

tgagcctggt ggactaaccg cctccagggg gcgcgtgcat gaagcctccc cgccaacctt     2940

ccagaaagat gctttgcttg gcagcaaacc taacaaacct tcactaccca gtagctctca     3000

aaacctgggc caaacagaag tgagtaaagt aagtgaaaca gttcaggaag agcttacccc     3060

gccaccacag aaagcggctc ctcaggggaa aagtaagtct gaccccctga aaaagaagac     3120

agacagagca ccaccatctc caccctgtga tatcacctgt cttgaaagtt ttcgtgactc     3180

aatggttctt ggatggaagc aaccagataa gattggaggg gcagaaatta ctggctatta     3240

tgtgaactat cgcgaggtca ttgatggggt accaggaaaa tggagagaag ccaatgtcaa     3300

ggctgtcagt gaggaggcat acaagattag caacttgaag gaaaacatgg tgtatcagtt     3360

ccaagtggca gccatgaaca tggctgggct gggcgcgccc tccgcagtaa gcgaatgctt     3420

caaatgtgaa gagtggacca tcgccgtccc aggaccaccg cacagtctca agtgtagtga     3480

agtcaggaaa gactcactgg ttctccagtg gaagccgcca gtccactccg ggcggactcc     3540

ggtcactggt tacttcgtgg acttgaagga ggccaaggcc aaagaagacc agtggcgagg     3600

gctcaatgag gcggctatta aaaacgtata cctgaaggtt cgaggcctca aggagggcgt     3660

cagctacgtg ttccgtgttc gagccataaa ccaggcggga gttgggaagc catctgacct     3720

tgctggccct gttgtggcag agacccgtcc aggaaccaaa gaggttgttg taaatgtgga     3780

tgatgatgga gtcatttcat tgaacttcga gtgtgataag atgactccaa agtccgagtt     3840

ctcctggtcc aaagattatg tatccactga ggactctcca cgattggaag tcgaaagcaa     3900

gggcaacaag acgaaaatga ccttcaaaga ccttgggatg gatgacttgg gtatttactc     3960

ttgcgatgta acagacactg atggaatagc atcaagctac ttaatagatg aggaagaatt     4020

gaaacgttta cttgctctca gccatgaaca caagttccca actgtcccag ttaaatcaga     4080

gttggcagtt gaaattttgg agaaaggcca ggtccggttt tggatgcagg ctgagaaact     4140

gtctggcaat gccaaagtca actacatatt taacgagaag gaaatttttg aaggcccgaa     4200

atataaaatg catattgacc gaaacactgg catcatcgaa atgttcatgg aaaagctaca     4260

ggatgaggat gagggaacgt acactttcca gcttcaagat ggaaaagcaa ctaaccattc     4320

tactgttgtt ctcgttggag atgttttcaa aaagctccag aaagaagctg aattccagcg     4380

gcaagaatgg atcaggaaac aaggtcctca ctttgttgag tatttgagct gggaagtgac     4440

tggtgaatgt aatgtactat tgaaatgcaa ggtggcaaat attaagaagg agactcatat     4500

tgtgtggtac aaagatgaga gggagatatc agtggatgaa aagcatgact ttaaggatgg     4560

tatatgtacc ctgcttataa cagagttttc caagaaagat gctgggattt atgaagttat     4620

cctgaaagat gaccgaggaa aagataagag cagactgaag cttgtggatg aagcctttaa     4680

ggaactgatg atggaagtat gcaaaaaaat agctttgtct gctacagacc tgaaaatcca     4740

gagcacagcc gagggcatcc aactgtactc ttttgtaact tactatgtgg aggatttgaa     4800

agttaactgg tcccacaatg ggtccgccat taggtactca gacagagtta agaccggggt     4860

cactggagag cagatctggc tacaaatcaa cgagcccacc ccgaatgaca aagggaagta     4920

tgtcatggag ctctttgatg gcaaaactgg acatcagaag acagtggatc tctctggaca     4980

agcatacgat gaggcctatg ctgaattcca gaggttgaaa caagctgcca ttgccgagaa     5040

aaatcgtgcc cgggtgttgg gaggtctccc agacgtggtc accatccagg aggggaaggc     5100

ccttaatctc acttgcaacg tgtggggaga cccgcctccg gaggtgtcgt ggttgaagaa     5160

cgagaaggcc ctggcctcag acgaccactg caacctcaag ttcgaggctg ggaggaccgc     5220

gtacttcacc atcaacggcg tgagcaccgc tgactcgggc aaatacgggc tggttgtgaa     5280

gaacaagtat ggctcggaga ccagcgactt caccgtcagc gtgttcatcc cagaggagga     5340

ggcgaggatg gccgccttgg agtccctgaa aggtggcaag aaggccaagt gaccggaggt     5400

gcgaggagag ccagccggcc tgtgtgactt gggtgtgaat ggtttgggtt aaggatgaga     5460

cgtcttcatg ctttctcctc cctattattt tctggcttga ggggaaaata atgtcaggtc     5520

tttcactcat ataaaaaagc accaactaat gacactttaa ttgtttttct ttatctacaa     5580

aattatgtgt taagaaaata ccattcatag catgaagatt aggaaacagt tttaaggaga     5640

agacttgaat gaagttggag ggacattgaa tgatggtcag agggcagacg aatgtgtcgt     5700

ggggcgaatt gggatttgct gcagctgtga agccatggcc gtgtctcgtg tgttgttaca     5760

gaggtgatgt gcttttcgac gggcgcctcg tggcttggaa cctcctctgt atgaataaac     5820

agttttcacg tctgtcctct tccccga                                         5847


<210> 1386
<211> 8320
<212> DNA
<213> Homo sapiens

<400> 1386
gatatagact gtcaatttcg gatccaaaga cggcgatggc agagctcacc cgggttgcct       60

gtcaaatcaa ggctatcgca gaataaatcc cgccgcctgc cgcgaagccc cggcgcaccg      120

caaacttcag tgagcgaact gggtgatcgc tgttgggata tgcagattcc tgatgtaaaa      180

ggcggggtgg cccccccgag agcctctccc gggggccgga gcccgcaggt gcagtgaggc      240

gcgcgcgccg gtgccggcgc ccccagagcc gccttgcccg ggtagaggga gcccggcgcc      300

cggcggggtc tggcggccgc acaccggcgg cggcggcttg tctgcggcgg ctgcagcgga      360

tgatggtggc ggccggcccg ctgggctgtg cctgtgtgtc gccgcggaaa tcagcgccct      420

gcgccgcgcg ctgagcccct gcaggtccgc cgcagcccca gcctcggcga ggacggcccc      480

ggcgcgcggg ggggcggggg gcgcgcgggg tcggcttatc atggcggatc ggacggcgcc      540

ccgctgccag ctccggctgg agtgggtgta cgggtaccgg ggtcaccagt gccgcaacaa      600

cctgtactac acggcaggca aggaggtggt ctactttgtg gctggggtcg gggtggttta      660

caacacccgc gagcacagcc aaaaattctt cctgggacac aacgacgaca ttatcagcct      720

tgccttacac ccagacaaaa ctctcgttgc aactggccaa gtcgggaagg agccatatat      780

atgcatatgg gattcctata atgtccagac tgtgtctctt cttaaagatg tccatacaca      840

tggagttgcc tgcctggctt ttgactcaga tggacagcgt ttagcctctg tggggttgga      900

tgccaaaaac acagtctgca tttgggactg gaggaaggga aaacttctgg cgtcagccac      960

cggccattct gacaggattt ttgatatttc ctgggatcca tatcagccaa acagagtggt     1020

tagctgtgga gtaaaacaca taaagttttg gacactgtgt ggaaatgccc tgactgcaaa     1080

aagagggata tttggcaaaa caggggatct tcagaccatc ctttgccttg catgtgccaa     1140

agaagacatc acctactctg gtgctttaaa tggtgacatc tatgtctgga aagggctcaa     1200

tttagtccgc accattcaag gagcacatag tgctggaatc tttagcatgt atgcttgtga     1260

agaaggcttt gccactggtg ggcgagatgg gtgtatacga ctgtgggaca ctgatttcaa     1320

accaataacc aaaattgatc tcagggagac agaacaagga tacaaaggcc tctctatccg     1380

gagcgtgtgc tggaaagcag accgccttct agcagggacc caggacagtg agatatttga     1440

agtgattgtg cgagagcgag acaagccgat gttgatccta cagggccact gcgagggtga     1500

gctctgggct ctggccctgc accccaagaa gcctctggct gtgacaggca gcgatgaccg     1560

ctctgtcagg ctgtggagcc tggctgatca tgccttgatc gcccgctgta acatggaaga     1620

ggcggttcgc agtgtagctt tcagccccga cggatctcag ctggccctgg gcatgaagga     1680

cggctctttc attgttctcc gagtcagaga tatgacagaa gtagttcaca tcaaagatcg     1740

aaaagaagtc attcatgaaa tgaaattttc tccagatggt tcttaccttg cagtgggatc     1800

caatgatggc ccagtagatg tctatgctgt tgcccagagg tataagaaaa ttggagaatg     1860

cagcaagtcc cttagtttca tcacgcatat tgactggtcc ttggatagta aatacttaca     1920

aactaatgac ggtgcaggag aacgattgtt ctacagaatg ccatctggga agcctttaac     1980

aagtaaagaa gaaattaaag ggattccttg ggcctcctgg acatgcgtga aaggccctga     2040

agtgagtgga atttggccca aatacactga ggttactgac atcaactcag tggatgcgaa     2100

ttacaacagc tcagtgctgg tgtctggaga tgattttgga ctggttaaat tgtttaaatt     2160

tccttgtctc aagagaggag ccaaatttag aaagtatgtg ggccattctg cacatgtcac     2220

aaatgtccgc tggtcccatg actttcagtg ggtgttgagc acaggagggg ctgatcactc     2280

agttttccag tggaggttta ttccagaagg tgtcagcaac ggcatgctgg aaactgcacc     2340

ccaagaaggt ggagctgatt cctacagtga agaatctgat tcagatttat ctgatgtgcc     2400

cgaactggac tctgatattg agcaagaagc tcaaatcaat tatgatcgcc aggtttacaa     2460

agaagatcta cctcagctaa agcaacaaag taaagagaaa aaccacgcag tgcccttcct     2520

caaacgagaa aaggctcctg aggacagctt gaaactccag ttcatacacg gttatagagg     2580

ctacgactgt agaaacaatc tgttctacac acaagctgga gaagtagtct accacattgc     2640

tgcagttgct gtcgtgtata atcggcagca gcactcccag aggctgtacc tggggcacga     2700

tgacgacatt ctcagcctga ccatccatcc agtgaaggac tatgtggcta ctgggcaggt     2760

tggaagagat gctgctattc atgtgtggga cacacaaact ctaaaatgtt tgtcgctgtt     2820

gaaaggacaa catcagagag gagtgtgtgc acttgatttt tcagccgatg gaaaatgtct     2880

ggtgtcggtt ggtttagacg attttcacag tattgtattt tgggactgga aaaagggaga     2940

aaagatagcc acaacaagag gacataaaga taagatattt gtggtaaagt gtaacccaca     3000

ccatgttgac aaactggtta cagttgggat aaaacacatc aaattctggc aacaagcagg     3060

tgggggcttc acttctaaaa gaggaacttt tggaagcgtt ggaaaattgg aaacaatgat     3120

gtgtgtttct tacggacgaa tggaagatct agtgttctca ggagcagcta ctggagatat     3180

ttttatttgg aaagacattc tactactgaa gacagtgaaa gctcatgatg ggcctgtgtt     3240

tgctatgtat gcactggata agggctttgt aacaggtgga aaggacggca tcgtggagct     3300

ctgggatgat atgtttgaaa gatgtttgaa gacttatgcc attaaaagat cagcattgtc     3360

gactagctca aaaggcttgc ttttggaaga taacccttca attcgtgcca tcactttggg     3420

acatggacat atcctggtgg gaacaaaaaa tggagagatt ctggaaattg ataagagtgg     3480

cccaatgaca ctgcttgttc aggggcacat ggaaggagaa gtgtgggggt tggcagctca     3540

ccctctcctg cccatctgtg caacagtgag cgatgataaa acacttcgca tctgggaact     3600

atctgcccag caccgtatgc tggcagtacg gaaactcaaa aaaggtggaa gatgctgtgc     3660

cttttcccct gatgggaaag ccttagcggt tggcttgaac gatgggagtt tcctggtggt     3720

aaatgctgac actgttgaag acatggtctc tttccatcac agaaaagaaa tgatctctga     3780

tattaagttt tcaaaagata cgggaaaata ccttgccgtg gcatcccatg ataactttgt     3840

ggatatttac aacgtactta caagcaaaag ggttggcatc tgtaaaggtg cttctagtta     3900

tattacacac attgactggg actctagagg aaaattattg caagtgaatt caggtgccag     3960

agaacaactt ttttttgaag ctccaagagg caaacggcat ataataagac cttcagagat     4020

cgagaagata gagtgggaca catggacctg tgtcctgggg cccacctgtg agggaatctg     4080

gccagcacat agcgatataa ctgacgtaaa tgctgccagt cttaccaaag actgttccct     4140

tttagccacc ggagatgatt ttggtttcgt taagcttttt tcatatcctg tcaagggaca     4200

gcacgcaaga ttcaagaagt atgtggggca cagtgcacat gtcactaacg tgaggtggct     4260

gcacaatgac tctgtgctgc tcacggtggg cggcgccgac acagccctga tgatctggac     4320

cagggagttt gtggggaccc aggagagcaa gctggtggac agcgaggagt cagacaccga     4380

cgtggaagag gatggaggct atgacagcga tgttgctaga gaaaaggcca ttgactacac     4440

caccaagatt tatgctgtga gcatcaggga aatggaaggc accaagccac accagcagct     4500

gaaggaagtt tccgtggaag aaagaccacc cgttagccga gcagctcccc agcctgagaa     4560

actgcagaag aacaatatca ccaaaaaaaa gaaactggtt gaggagctgg ctctagacca     4620

cgtgtttggc tacagaggtt tcgactgtcg aaataacctg cattacctta atgatggcgc     4680

tgacatcatc ttccacacag cagcggctgg catcgttcag aacctctcca cagggagcca     4740

gagcttctat ctggagcaca cagatgacat cctctgtctc acagtgaacc agcaccccaa     4800

gtacagaaac gtggtggcca ccagccagat agggacaaca ccttccatcc acatatggga     4860

cgccatgacc aaacacaccc tctccatgct gcggtgcttc cactccaagg gggtgaatta     4920

catcaacttc agtgcaactg gaaagctcct ggtgtcggtg ggagtggacc ctgagcacac     4980

catcactgtc tggcgatggc aggaaggtgc caaggttgcc agccgagggg gtcacctgga     5040

gcgcatattt gtggtggaat ttcgccccga ctcagacacg cagtttgtat ctgtcggggt     5100

caaacatatg aagttctgga ccctggcagg cagcgccttg ctttacaaga aaggggtcat     5160

cgggtccctg ggagctgcca aaatgcagac gatgctctcc gtggccttcg gtgctaacaa     5220

tctcactttc acgggtgcca tcaatggaga tgtctacgtc tggaaggacc acttcctcat     5280

ccggctggtg gccaaggctc acacaggccc cgtgttcaca atgtacacaa cccttcggga     5340

tggactcata gtgaccggcg gaaaagagag gccgaccaaa gaaggaggtg ctgtaaaatt     5400

gtgggaccag gagatgaagc gctgccgggc ctttcagctg gagaccgggc agctggtgga     5460

gtgtgtgcgc tccgtgtgcc gtggaaaagg aaaaatctta gtgggaacca aagacggaga     5520

aataattgaa gttggtgaaa aaaatgctgc ttctaacatc ctgattgatg gtcacatgga     5580

aggggagatc tggggcctgg ccactcaccc ttccaaggac ctcttcatct ctgccagcaa     5640

cgatggcaca gcccggatct gggacctggc tgacaagaag ctgttaaaca aggtgagctt     5700

gggccatgcg gccaggtgtg cagcctacag ccctgatggg gagatggtgg ccattggcat     5760

gaagaatgga gagtttgtca tcttgttggt gaacagcctg aaagtttggg ggaaaaaacg     5820

agaccggaaa tctgctatcc aagatatcag aatcagccca gacaaccgat tcttagccgt     5880

tggttcttct gaacacacag ttgacttcta tgacctcact cagggcacaa atctgaaccg     5940

cattggctac tgcaaagata tcccaagctt tgtcattcag atggattttt ctgcggatgg     6000

caaatacatt caggtgtcaa caggtgccta taagcgccag gtgcatgagg tccccctggg     6060

gaagcaggta actgaagccg tggtcattga gaagatcacc tgggcctcct ggacaagcgt     6120

cctgggagat gaagtcattg gaatctggcc acgaaatgca gacaaggctg atgtcaactg     6180

cgcatgtgtg acccacgctg gcctgaacat tgtcacagga gatgactttg ggctggtgaa     6240

gctctttgat tttccatgca cagaaaaatt tgccaaacat aagcgatact tcggtcactc     6300

ggctcacgtg acgaacatcc gtttctctta tgatgacaag tatgtggtca gcactggagg     6360

agacgactgc agtgtatttg tgtggcgatg tctgtaaaat gccagaagcc tcttatgtta     6420

ttgctgctgc tgctaccagc cagcaactgc agaggccatg ctgaggtgcc tccttgccac     6480

cagccgttgg gaaatgccta ccatgctgcc ccggatgcac aagctcaaaa cgctgcagaa     6540

gttacacaac tgctcccata atctggactc tccaaaaccg tgatgccacg aaggaaggtc     6600

aagttttaaa atgttaaaga ctgcttgcct ctgttcctga gactaaacag tatacatact     6660

aactacattg acaaagaaat cctatctgat aatgtagccc gctgacgaat tttgaagcct     6720

cggttaccct aaccaatatg tagcttttaa tttgcatcaa aacttttaca aagatgtttt     6780

gctattgttt ctatatactt caagaatgtt catttttaca aataagttga acaagacagc     6840

ctaagttaga tgcaccgaag tactagaaat atcgctagcc tctgttctcc agtttagctt     6900

tcaaaaccaa atgagccatg tataaaggag ttgagaaact taatttttaa atgtttcatt     6960

tgcagagttt tatatccatt aagtgccttt gaaagtttcc agttgtgtgg gctgctgtct     7020

cacctcccac caatttctcc tttctccata tggtgctaaa acctcaaagc tgaggagggc     7080

tgcaggaccc ttagcagatt cagtgtgtca cccttgtcct gtgttcacgc caaggcttcc     7140

taaatgaaag acatcggtta cctgcttatg ggaaggtgag cagcaaagga attgaagttc     7200

gggacagggt agaattatgg gttttcattg tgtttcatgc caaacccaca aaatccaaaa     7260

tagaattcaa gttaaacaaa cttctactac aaaatggaag gggaaaaagg ctcaggaagg     7320

tctatgagaa tgagctgact tatctcgtta aatcttaaga taaatgaggg taacccaagg     7380

ctgcaccttg gtgtaccacc ctgagtggag ttgaggtgac ttcatttgat tgcttcaggc     7440

gaactatata ggtcaagtcc agattataaa aaaattatct gcagaacaaa ttgtaaaccc     7500

aaggaatagc tggtaaatca aaattataaa gtgagttaga gttccttgga gttggttgta     7560

tgacggaata tgacttggac aatctttacc agaagccatc cgtaagcccc tcagtcacac     7620

tttccatgta gctgaccagt gactacagga tgtggctgac agtgctcact gaaaggagag     7680

ttggtgcggg actggtggtt ctgagcacat agacgcctat tagtccttct ggtcagtgaa     7740

cgaaaattct agacctacag ttactggcta cttgcatttg tcagtttaga gaaaaggtaa     7800

aatgaggcat tttcaattgt agaatagact aacatttacc acagaagtgc ttcagcattc     7860

taaatggatt agatcactca ttaagctatt tttatatgcc aatttactaa tgccttacat     7920

caatccacta ataggttgtt gggcccgcag tagagtccct atgcagtccc aattctgttt     7980

tctgtaacca tgtgactggt gatgcagagt gataaccatg tctgcctatc ttgtactaga     8040

ctcttcatgc tgatcggatc ttgcattgaa ataaccatgt ggaagaacaa tgaatcgatt     8100

aatgatgaca tgtacaacca tatttaaaga gcaatagtgt ccgtgtgtca tgaaaaactt     8160

atttgtaaac gtttatatgg tatgattttg attttatgta tgttcataaa tcctgcactg     8220

tatgatatat gtgagttaaa acattggtgc atgaatttat tttcaaagta taaaacacat     8280

cacttaaaca ttttatgtgt caaataaaat ttgattatgt                           8320


<210> 1387
<211> 1133
<212> DNA
<213> Homo sapiens

<400> 1387
gtctgcgtca gttggtcacg tggttgttcg gagcgggcga gcggagttag cagggcttta       60

ctgcagagcg cgccgggcac tccagcgacc gtggggatca gcgtaggtga gctgtggcct      120

tttgcgaggt gctgcagcca tagctacgtg cgttcgctac gaggattgag cgtctccacc      180

catcttctgt gcttcaccat ctacataatg aatcccagta tgaagcagaa acaagaagaa      240

atcaaagaga atataaagaa tagttctgtc ccaagaagaa ctctgaagat gattcagcct      300

tctgcatctg gatctcttgt tggaagagaa aatgagctgt ccgcaggctt gtccaaaagg      360

aaacatcgga atgaccactt aacatctaca acttccagcc ctggggttat tgtcccagaa      420

tctagtgaaa ataaaaatct tggaggagtc acccaggagt catttgatct tatgattaaa      480

gaaaatccat cctctcagta ttggaaggaa gtggcagaaa aacggagaaa ggcgctgtat      540

gaagcactta aggaaaatga gaaacttcat aaagaaattg aacaaaagga caatgaaatt      600

gcccgcctga aaaaggagaa taaagaactg gcagaagtag cagaacatgt acagtatatg      660

gcagagctaa tagagagact gaatggtgaa cctctggata attttgaatc actggataat      720

caggaatttg attctgaaga agaaactgtt gaggattctc tagtggaaga ctcagaaatt      780

ggcacgtgtg ctgaaggaac tgtatcttcc tctacggatg caaagccatg tatatgaaat      840

gcattaatat ttgactgttg agaattttac tgccgaagtt tacctccact agttctttgt      900

agcagagtac ataactacat aatgccaact ctggaatcaa atttccttgt ttgaatcctg      960

ggaccctatt gcattaaagt acaaatacta tgtattttta atctatgatg gtttatgtga     1020

ataggatttt ctcagttgtc agccatgact tatgtttatt actaaataaa cttcaaactc     1080

ctgttgaaca ttgtgtataa cttagaataa tgaaatataa ggagtatgtg tag            1133


<210> 1388
<211> 1886
<212> DNA
<213> Homo sapiens

<400> 1388
gcgccccctg cgctgccaac ccgcgagccc gcatcatgga tgtcgagctc ccctatttcg       60

cattgctagc cctggaattc gagaccccag acgaggacca ggattcatga aatcagtcgc      120

aggggccggg gcaggggcct ctggctcccg acactggccg agaggtgatg agtgaggttc      180

gaagaacgga agatttaaaa agcagccggg gcctccgtat tgaatgaaag acccagtgca      240

aagacatcac catgaacact agcattcctt atcagcagaa tccttacaat ccacggggca      300

gctccaatgt catccagtgc taccgctgtg gagacacctg caaaggggaa gtggtccgcg      360

tgcacaacaa ccacttccac atcagatgct tcacctgtca agtatgtggc tgtggcctgg      420

cccagtcagg cttcttcttc aagaaccagg agtacatctg cacccaggac taccagcaac      480

tctatggcac ccgctgtgac agctgccggg acttcatcac aggcgaagtc atctcggccc      540

tgggccgcac ttaccacccc aagtgcttcg tgtgcagctt gtgcaggaag cctttcccca      600

ttggagacaa ggtgaccttc agcggtaaag aatgtgtgtg ccaaacgtgc tcccagtcca      660

tggccagcag taagcccatc aagattcgtg gaccaagcca ctgtgccggg tgcaaggagg      720

agatcaagca cggccagtca ctcctggctc tggacaagca gtggcacgtc agctgcttca      780

agtgccagac ctgcagcgtc atcctcaccg gggagtatat cagcaaggat ggtgttccat      840

actgtgagtc cgactaccat gcccagtttg gcattaaatg tgagacttgt gaccgataca      900

tcagtggcag agtcttggag gcaggaggga agcactacca cccaacctgt gccaggtgtg      960

tacgctgcca ccagatgttc accgaaggag aggaaatgta cctcacaggt tccgaggttt     1020

ggcaccccat ctgcaaacag gcagcccggg cagagaagaa gttaaagcat agacggacat     1080

ctgaaacctc catctcaccc cctggatcca gcattgggtc acccaaccga gtcatctgcg     1140

acatctacga gaacctggac ctccggcaga gacgggcctc cagcccgggg tacatagact     1200

cccccaccta cagccggcag ggcatgtccc ccaccttctc ccgctcacct caccactact     1260

accgctctgg tgatttgtct acagcaacca agagcaaaac aagtgaagac atcagccaga     1320

cctccaagta cagtcccatc tactcgccag acccctacta tgcttcggag tctgagtact     1380

ggacctacca tgggtccccc aaagtgcccc gagccagaag gttctcgtct ggaggagagg     1440

aggatgattt tgaccgcagc atgcacaagc tccaaagtgg aattggccgg ctgattctga     1500

aggaagaaat gaaggcccgg tcgagctcct atgcagatcc ctggacccct ccccggagct     1560

ccaccagcag ccgggaagcc ctgcacacag ctggctatga gatgtccctc aatggctccc     1620

ctcggtcgca ctacctggct gacagtgatc ctctcatctc caaatctgcc tccctgcctg     1680

cctaccgaag aaatgggctg cacaggacac ccagcgcaga cctcttccac tacgacagca     1740

tgaacgcagt caactggggc atgcgagagt acaagatcta cccttatgaa ctgctgctgg     1800

tgactacaag aggaagaaac cgactgccca aggatgtaga caggacccgt ttagagggaa     1860

acttttggaa gagtggctgc ttatga                                          1886


<210> 1389
<211> 2166
<212> DNA
<213> Homo sapiens

<400> 1389
ggccctcgcg gggggcttgt gggtcctcct ccccctccca ctgacaactg ccccaactgc       60

tcttcccgcc ccggtcacag tgaaaatgta gacggggtcg ttgtccacta tgttaggtct      120

taatggtggg aggacgcccg agtgctcggc ccgtttcacc ccgaggagga aggacactgg      180

gtcatgacgc catcagaggg cgccagagca gggaccggac gcgagttgga gatgttggac      240

tcgctgttgg ccttgggcgg cctggtgctg cttcgggatt ccgtggagtg ggaggggcgc      300

agtctcttga aggcgcttgt caagaaatct gcactgtgtg gggagcaagt gcatatcctg      360

ggctgtgaag tgagcgagga agagtttcgt gaaggttttg actctgatat caacaatcgg      420

ctggtttacc atgacttctt cagagaccct ctcaactggt caaaaactga ggaggccttt      480

cctggggggc cgctgggagc cttgagagcc atgtgcaaga ggacagatcc tgttcctgtc      540

accattgctc tcgattcact cagctggctg ctacttcgcc ttccctgcac cacactctgc      600

caggtcctgc atgctgtgag ccatcaggac tcttgtcctg gtgacagctc ctcagtgggg      660

aaagtgagtg tgctgggctt gctacatgaa gagcttcatg gaccaggccc tgtgggagct      720

ctcagcagcc ttgctcagac tgaggtgacc ctgggcggta ccatgggcca ggcctcggcc      780

cacatcctgt gtcggaggcc ccgacagcgc ccaactgacc agactcagtg gttctccatc      840

cttccggact tcagcctgga tctccaagag gggccctctg tagagtccca gccctactcc      900

gatcctcata tacccccggt atctaagaat gccaaggcca gaacaaggaa atgtagttta      960

gtatctggtc acgggagaga aaataaaagc tgcagaggtt gggggtgggg tcagggattc     1020

tagggatggg gcagagtggc agcatccttt gtacctacag gtggatccca caactcattt     1080

gacctttaac cttcacctgt ccaagaaaga gagagaagcc agagatagcc tgatcctgcc     1140

cttccagttc agttctgaaa agtaaggttg ggacctgggt acgtggatcc ctgagtagat     1200

cccagcatct gggccatgga gaggttgggg caacaggtta ttgattaacc tgactttata     1260

gggactgaag tccacctcca gagacaagtc caagttcttg atccacccat tccccctata     1320

atggcagagg acctttatgt ctcttttctc tcccttatac ccttgggtca cagctccagt     1380

tgtccccaga gcaccctggg cctgggctga gccagaccag acccttggga ggtggcccta     1440

tccctaggca gtggtgctag gaggacagaa ggctatatgg gcgtggcaga ggctggttaa     1500

caagggctta gtacacgctt gctgttctgt gcccagtatg tgggcggatg acgcaagact     1560

acaagatcct tgccctcaag ctgctaggaa cttacggttt tattaggaga gcagtacaag     1620

ggtatctatc ccagtaccaa atggtgcttc agctctaaca tggaggtcag agaaagggac     1680

ttggaccaat aaaatgacat ggaggcctaa caggttgcct gaatgagagt cacagtcacc     1740

tggaagaaag tatccagacc caacctgtta gctaccctca ccagcaccaa atcttccctt     1800

ctcagacagc aggctctcct gcggcctagg ccagggcagg ctaccagcca catcttctat     1860

gagccagatg cttatgatga cctggaccaa gaagacccag atgacgacct ggatatttga     1920

ctggccagat ttgattagat tgtaattgga gggggcgcgg gaagactttg ggcccagaac     1980

catctttcta ttgtttgtgt tagccttacc ctgtccctgc cccaccttgg ttccccttgt     2040

ctatggagcc ccgccttgtg agccaggaag cagcgtctca tcaggacaga aggtaggatg     2100

aagacatggg gtaatgtgag agagtagaac acccccgtac ctaataaaaa tctttatttt     2160

tttatt                                                                2166


<210> 1390
<211> 834
<212> DNA
<213> Homo sapiens

<400> 1390
ggacagcttg gagatagggc ccggaattgc gggcgtcact ctgctcctgc gacctagcca       60

ggcgtgaggg agtgacagca gcgcattcgc gggacgagag cgatgagtga gaacgccgca      120

ccaggccttt gcggggagct tctcctgcaa agaggaacca cgaaggtggc cacaggtctg      180

gttctgaaca gagaccagag gctcgcctgg gcagagaaca gcattgactt catcagcagg      240

gagctgtgtg cgcattccat caggaagctg caggcccatg tcctgttgat caaagcagtc      300

cacggatatt ttgattcaag acagaattac tctgagaagg agtccctgtc gttcatgata      360

gacacgatga aatccaccct caaagagcag ttccagtttg tggaagtccc aggcaatcac      420

tgtgtccaca tgagcgaacc ccagcacgtg gccagtatca tcagctcctt cttacagtgc      480

acacacatgc tcccagccca gctgtagctc tgggcctgga actatgaaga cctagtgctc      540

ccagactcaa cactgggact ctgagttcct gagccccaca acaaggccag ggatggtggg      600

gacaggcctc actagtcttg aggcccagcc taggatggta gtcaggggaa ggagcgagat      660

tccaacttca acatctgtga cctcaagggg gagacagagt ctgggttcca gggctgcttt      720

ctcctggcta ataataaata tccagccagc tggaggaagg aagggcaggc tgggcccacc      780

tagcctttcc ctgctgccca actggatgga aaataaaagg ttcttgtatt ctca            834


<210> 1391
<211> 3667
<212> DNA
<213> Homo sapiens

<400> 1391
gtgctgctag aaaccacgaa cattagtcat ctcgcagcat gtgtgcacat ggggtgaccc       60

gggggcctcc tcgaatgcag cgtctacgcc tggtgaatgg acgcactctt accaattctg      120

ctctgggaga tgcagcggta acctaccgag cgcagaggcc ggcgcgcacc cgtggagccc      180

gcgctcgcga tccctcctcg tgccagggcc ccagggcagt caaggcctgc cgaccgttag      240

gcgggtcaag gggtacacag ggtgcgaatt cgttaggcaa aagctgggta caggcgcgag      300

ccacaggcac ggaaacctcg cgccgaccgg ggccctaggc ccgacgacgg caggtaaggg      360

gaagtggagg cacacagggc tgggacgtgc cccaggcacc atacgggtgg cttcgggcgc      420

gggacgtccg cagccccgca gctcccagga cgttcgacaa tctgcagctg accagcttcg      480

gccggtttgg ggataaaggg aagacaggcg gcgcggggag tgggaacgcc tgaaggccgc      540

gcccctcctt tcaggtcggc caggagcgcg ccggtaagag cctgggggca aggggtagaa      600

agacgcccac ctcatcacaa cccagagctc gggactccta tacagtccca tagggaacag      660

gcggccgcca ttcccctccc ccacgctggc gggtaaggct agagaacggt ttcaaggaag      720

acgcatgcgc atgaaataat tataaaccgc taggactccg aagttcaata ttcgcgggaa      780

ggcgcaggcg caacaaaaag cccggcgggt ttatgggtgg gggtgctgag cccaaaaccc      840

aagcgtgtaa taatccgccg gcgggaggtg ggctggctct tgaaattacg catgcgccag      900

agctctttgt gacgcaacgg ggcggtgcgg gcagctggct gcgcgtgcgc agaactcgca      960

caagggacct tatttaggtt gcgcaggcgc ccgctggcca tttcgtctta gccacgcaga     1020

agtcgcgtgt ctaggtgagt cgcggtgggt cctcgcttgc agttcagcga ccacggtggg     1080

taccgttttt gcgaggattg tttgtcccca tatctctggg agggccacgg ggaccttggc     1140

gagctgcagg ctgccgtcga gagccgcgag tggttcgctg aatctcggca ccgccgctga     1200

ggcctgcagg ccgcgccgac tctattgtgt gagaagtcgg aggaggcgga gcggaagcgg     1260

ccgccgccat ttcctttcct ctacgctggc tctcggcccg ggcccccacg gttcggggcg     1320

ccgacagctg ttgctcagga cagctttggg ggtccggtcg ccggacgagg aggtgttgga     1380

gtcgccgggg tgggtgcatc cgcccggttt ttgctccgtg ggggggcggt gcgggcccgg     1440

gcgcgcctcg gaggcgaagg acagcttaat tggcgctctc agttctggtc ctccccgctt     1500

tgcagtttgt ttcgacgccg gaccgcgtaa gagacgatga tgttgggcac ggaaggtgga     1560

gagggattcg tggtgaaggt ccggggcttg ccctggtctt gctcggccga tgaagtgcag     1620

aggttttttt ctgactgcaa aattcaaaat ggggctcaag gtattcgttt catctacacc     1680

agagaaggca gaccaagtgg cgaggctttt gttgaacttg aatcagaaga tgaagtcaaa     1740

ttggccctga aaaaagacag agaaactatg ggacacagat atgttgaagt attcaagtca     1800

aacaacgttg aaatggattg ggtgttgaag catactggtc caaatagtcc tgacacggcc     1860

aatgatggct ttgtacggct tagaggactt ccctttggat gtagcaagga agaaattgtt     1920

cagttcttct cagggttgga aatcgtgcca aatgggataa cattgccggt ggacttccag     1980

gggaggagta cgggggaggc cttcgtgcag tttgcttcac aggaaatagc tgaaaaggct     2040

ctaaagaaac acaaggaaag aatagggcac aggtatattg aaatctttaa gagcagtaga     2100

gctgaagtta gaactcatta tgatccacca cgaaagctta tggccatgca gcggccaggt     2160

ccttatgaca gacctggggc tggtagaggg tataacagca ttggcagagg agctggcttt     2220

gagaggatga ggcgtggtgc ttatggtgga ggctatggag gctatgatga ttacaatggc     2280

tataatgatg gctatggatt tgggtcagat agatttggaa gagacctcaa ttactgtttt     2340

tcaggaatgt ctgatcacag atacggggat ggtggctcta ctttccagag cacaacagga     2400

cactgtgtac acatgcgggg attaccttac agagctactg agaatgacat ttataatttt     2460

ttttcaccgc tcaaccctgt gagagtacac attgaaattg gtcctgatgg cagagtaact     2520

ggtgaagcag atgtcgagtt cgcaactcat gaagatgctg tggcagctat gtcaaaagac     2580

aaagcaaata tgcaacacag atatgtagaa ctcttcttga attctacagc aggagcaagc     2640

ggtggtgctt acgaacacag atatgtagaa ctcttcttga attctacagc aggagcaagc     2700

ggtggtgctt atggtagcca aatgatggga ggcatgggct tgtcaaacca gtccagctac     2760

gggggcccag ccagccagca gctgagtggg ggttacggag gcggctacgg tggccagagc     2820

agcatgagtg gatacgacca agttttacag gaaaactcca gtgattttca atcaaacatt     2880

gcataggtaa ccaaggagca gtgaacagca gctactacag tagtggaagc cgtgcatcta     2940

tgggcgtgaa cggaatggga gggttgtcta gcatgtccag tatgagtggt ggatggggaa     3000

tgtaattgat cgatcctgat cactgactct tggtcaacct tttttttttt tttttttttt     3060

tctttaagaa aacttcagtt taacagtttc tgcaatacaa gcttgtgatt tatgcttact     3120

ctaagtggaa atcaggattg ttatgaagac ttaaggccca gtatttttga atacaatact     3180

catctaggat gtaacagtga agctgagtaa actataactg ttaaacttaa gttccagctt     3240

ttctcaagtt agttatagga tgtacttaag cagtaagcgt atttaggtaa aagcagttga     3300

attatgttaa atgttgccct ttgccacgtt aaattgaaca ctgttttgga tgcatgttga     3360

aagacatgct tttatttttt tgtaaaacaa tataggagct gtgtctacta ttaaaagtga     3420

aacattttgg catgtttgtt aattctagtt tcatttaata acctgtaagg cacgtaagtt     3480

taagcttttt ttttttttaa gttaatggga aaaatttgag acgcaatacc aatacttagg     3540

attttggtct tggtgtttgt atgaaattct gaggccttga tttaaatctt tcattgtatt     3600

gtgatttcct tttaggtata ttgcgctaag tgaaacttgt caaataaatc ctccttttaa     3660

aaactgc                                                               3667


<210> 1392
<211> 5015
<212> DNA
<213> Homo sapiens

<400> 1392
gaggtcagac cggttgcttt cccgggagtt cggcgtttgc tggggctgca gcagctgaag       60

tgtagtgttt tcttgggact ggcggtctgc acttctctcc cgggttccat ctccccccgc      120

ccggtggtga ggccctcgag gagggctcgg acgggtgtag cgatccgcgc tagaggaaga      180

cgaggcccgg gaacgcatgt cccccagggc aggttagggg gctggagggg tcaaatcccg      240

gggtacttgt ggagactctt tagcgtggct tcttctctct gctgagaccc cgagagcttt      300

cccagttctc ctcccaggac caccggggtt cctgaagatc gggacttttc tgcgcccctc      360

caccaacagc ccatctcctg tctatgaaga aagacccttc gtagaaacaa cttccccgct      420

gctgacgcgt tttcccgtcc cgtccccgaa gtagtctact atgacctcgt tgtgagcctc      480

tgaacgattt tgacactttc ccgaggccta gggtattata tcctaacctt actaaagacc      540

acagaggtgc ttgccattat gggaaatcag cttgctggca ttgctccctc ccagatcctt      600

tctgtagaga gttatttttc agatattcat gactttgaat atgataaaag cctggggagt      660

actcggtttt ttaaagttgc tcgagccaag caccgagaag gcctggtcgt tgtgaaggtt      720

tttgcaattc aggatcccac attgccttta accagctata aacaagagct ggaggaactg      780

aaaatcaggc ttaattctgc acagaattgt ctacctttcc agaaagcatc agaaaaagca      840

tctgagaaag cagctatgct ctttaggcag tatgtgcgag acaatctcta tgatcgcatc      900

agtacccgtc cattcttgaa taacattgag aagcgctgga ttgctttcca gatcctgaca      960

gctgtggacc aagcacacaa atctggagtt cgtcatgggg acatcaagac tgagaatgtg     1020

atggtcacca gttggaattg ggttcttcta actgattttg ccagttttaa gcccacttat     1080

cttccagaag acaacccggc agatttcaat tatttctttg acacatcacg gaggagaact     1140

tgctatattg ctcctgaacg ttttgttgat ggtgggatgt ttgccactga gttagaatat     1200

atgagagatc cttcaactcc gcttgtagac ttaaatagca atcagagaac aagaggagag     1260

ttgaagagag caatggacat cttttcagca ggttgtgtga tagctgagct ttttacagaa     1320

ggtgtaccat tatttgatct ctctcaactt ttggcttata gaaatggaca ttttttccct     1380

gaacaagtgc taaataaaat tgaagatcac agtatcagag aattggtaac tcagatgatt     1440

caccgtgagc cagataaacg tttagaggca gaagattact taaaacagca gcgtggcaat     1500

gcctttcctg aaatatttta cacttttctt cagccctaca tggcccagtt tgccaaggaa     1560

acgtttcttt ctgcagatga gcgtattctg gttatacgga aggatttggg caacattatt     1620

cacaatctct gtggacatga tctgccagaa aaagccgaag gagagcctaa ggaaaatggg     1680

ctggttatct tggtatctgt tataacatcc tgcctacaga cccttaaata ctgtgattcc     1740

aaactagctg ctttggaact gattcttcat ttggctccaa gattaagtgt tgaaatcctt     1800

ttggatcgta ttactccata tcttttgcat ttcagcaatg actctgttcc tagggtgagg     1860

gctgaagcct tgaggacgtt gaccaaagtt cttgctctcg tcaaagaggt tcctcgtaat     1920

gatatcaata tttatccgga atacattctg ccaggcatag cccacttagc ccaagatgat     1980

gctactatcg ttagactagc ctatgctgaa aacatagctc tgctggcaga aacagctctg     2040

agattcctgg aattagtaca gttaaaaaat cttaatatgg aaaatgaccc caataatgaa     2100

gaaatagatg aggttacaca tccaaatgga aattatgaca cagagctcca agccttacat     2160

gaaatggtcc agcagaaagt tgttactttg ctaagtgacc ctgaaaatat tgtaaaacaa     2220

accttgatgg aaaatggaat aacacggctg tgtgtattct ttggacgtca gaaagccaac     2280

gatgttttgt tgtcccacat gattactttc ctaaatgata agaatgattg gcatctacgt     2340

ggagcatttt ttgatagtat agttggtgtt gctgcctatg ttggctggca aagctcctca     2400

attctcaagc ctctgctgca acaaggtctt agtgatgctg aggaatttgt cattgtgaaa     2460

gctctttatg cccttacttg tatgtgccag ttaggactgc tacaaaaacc ccatgtttac     2520

gaatttgcca gtgatattgc ccccttcctg tgtcatccca atttatggat acgttatggt     2580

gccgtgggat ttatcacagt ggtagctcgt caaataagta cagctgatgt ctactgtaaa     2640

ctgatgcctt atcttgaccc atatattacc caaccaataa tacagattga aagaaaactt     2700

gttctgctca gtgttttaaa ggaaccagta agtcgttcta tatttgatta tgctttgagg     2760

tctaaagata ttactagctt gttcagacat cttcacatgc gtcagaagaa acgaaatggt     2820

tctcttcccg actgccctcc gccagaggat cctgccatag cacagcttct gaagaagttg     2880

ctctcacagg gaatgacaga ggaagaggaa gacaaacttc tggcactgaa agacttcatg     2940

atgaaatcta ataaagcaaa ggccaatata gtggaccaga gccatcttca tgatagtagt     3000

cagaaaggtg taattgactt ggcagcttta ggcataactg ggagacaagt tgatcttgtt     3060

aaaaccaaac aagaaccaga tgacaaacgg gccagaaaac atgtaaaaca agactcaaat     3120

gtaaatgaag aatggaaaag catgtttggg tcactggacc caccaaacat gccacaggcc     3180

ctacctaaag ggagtgatca ggaggtgatt cagactggga aacctcctcg ttccgagtcc     3240

tctgctggca tttgtgtccc tttgtcaact tcttcacagg ttccagaagt gacaactgtc     3300

caaaataaaa aaccagtaat accggtttta agtagtacaa tcttaccatc cacctatcag     3360

attcgaatta caacttgtaa aactgaactt cagcaactca tccagcaaaa gcgggagcag     3420

tgcaatgctg agagaatagc taagcagatg atggaaaatg ctgaatggga gagtaaacca     3480

ccaccacctg gatggcgtcc taaagggctg ttagttgccc atcttcatga gcataaatct     3540

gctgtgaatc gaattagagt ctctgatgaa cactcacttt ttgcaacatg ttcaaatgat     3600

ggcacagtga aaatctggaa cagtcaaaag atggagggga agaccaccac taccagatct     3660

attcttacat acagccgaat tggaggacga gtcaagacgc tcacattctg ccaaggctcc     3720

cactatttag ccatagcatc tgataatggt gctgtccagc ttcttggaat tgaggcttct     3780

aagctgccca agtctcctaa aatccatcct ctacaaagca gaattctaga tcagaaggag     3840

gacggttgtg ttgtggatat gcatcacttc aactctggag cacagtctgt tcttgcctat     3900

gccactgtga atggctctct ggttggctgg gaccttaggt cttcaagcaa tgcgtggact     3960

ttaaagcatg atttaaagtc gggcctcatc acttcctttg ctgtggacat ccaccaatgc     4020

tggctctgca ttggtacaag cagtggtacc atggcttgtt gggacatgag gttccagttg     4080

ccaatttcaa gtcactgtca tccttccagg gctcgaatca gacgcctctc aatgcaccct     4140

ctgtatcagt cctgggtgat tgcagctgtt cagggcaaca acgaagtgtc catgtgggac     4200

atggagactg gtgacagaag atttactctc tgggccagca gtgcaccacc actttctgaa     4260

ttacagcctt ctcctcatag cgtccatggt atctactgta gtcctgcaga tggaaatcct     4320

atcctactaa cagctggctc agatatgaaa ataaggtttt gggacttggc ttacccagaa     4380

aggtcctatg ttgttgcagg aagtactagt tccccatctg tgtcctacta caggaaaata     4440

attgaaggca ctgaagttgt ccaggaaatt cagaataagc agaaagtagg accaagtgat     4500

gacacccctc gaaggggccc agagtccctg cccgtgggac atcatgacat catcactgat     4560

gtcgccacat tccagaccac acagggcttc atcgtaactg cttctagaga tgggattgtg     4620

aaggtgtgga aataaaacct actgatttgt ataaatttta atagttataa atataatact     4680

ataactcgag aaaaggcatt tctagagaac agattcattt gcttaatttt caaaattatg     4740

tctccatatt actgtttcat gactgactga ctaaatgaca cccaaaatgg ttaagatgta     4800

cttgactagt ttacttatgc atctctttgc aagaatcagc cagccaacaa tgtctgggat     4860

ttttattgta tatgttatag aggtgagaaa tgtaaaatat gaaaatgaat atgtttattt     4920

tgtattgaaa aagatggttg aaaagatggt tgtaagctat tatagtataa acacattttt     4980

gctattaaaa atgctattca aagcagttaa actgt                                5015


<210> 1393
<211> 1289
<212> DNA
<213> Homo sapiens

<400> 1393
gcctgggagg agactctctg agggtgtaga gctagaggga gcattcactg gccatgccag       60

tagttaccac tgatgctgag tcagaaacag gtatcccaaa atccctttcc aatgagcctc      120

cctcagaaac catggaggaa atagagcaca catgcccaca gcctcgactg accctgactg      180

cacctgcccc atttgctgat gaaaccaact gccagtgtca agcaccccat gaaaaactga      240

ccattgctca ggcccgctta ggaacaccag ctgacaggcc tgtcagagta tacgccgatg      300

gaatatttga cctcttccac tcaggtcatg caagagccct tatgcaagca aaaacactgt      360

ttcccaacag ctacttgttg gtaggagttt gcagtgatga tctcacccac aaattcaaag      420

gtttcaccgt gatgaatgaa gccgagagat acgaagctct cagacactgt cgctacgtag      480

acgaagttat cagagatgct ccctggacac tcacgccaga gtttctggaa aaacacaaga      540

ttgactttgt ggctcatgat gacattccgt attcctctgc tggctctgat gatgtttaca      600

agcacataaa ggaagcaggg atgttcgttc caacgcagag aacagaaggc atctcaacat      660

cggacatcat taccagaatt gttcgtgact atgatgttta tgcccgacgt aacctccaga      720

gagggtatac agccaaggaa ctgaatgtca gctttataaa tgagaagagg taccgtttcc      780

agaaccaagt ggacaaaatg aaggaaaaag tcaagaatgt ggaggaaaga tcaaaggaat      840

ttgtgaacag agtggaagaa aagagccatg atctaattca aaagtgggaa gagaagtcaa      900

gggaattcat tggcaacttc ctagaactgt ttggacctga tggagcatgg aagcagatgt      960

tccaggagag gagcagccgg atgctgcagg ccttatcccc gaagcagagc cctctgaaga     1020

gttgggcgag gtgcagagac ttctagctgg acaacctaca caaaccttag cgtctagagt     1080

cactctaacc ttgctaagga aggatgcaga gttccctaga gagacttgca ctgatggggt     1140

gacttctgct ttggtccttc caccaccccc accaagtaaa ccacctgtgg cagcggctgt     1200

tccctcaacc tgctacttct gcgtccataa gggtcctgca cgttgcctcc caccacccca     1260

gctctgccag aataaaattg tttccaata                                       1289


<210> 1394
<211> 3466
<212> DNA
<213> Homo sapiens

<400> 1394
gccagcgtcc cacaccagcc gcaggtgaaa accggcagaa agacattaag agattttcct       60

gcagtcactg ctggcagatg atagagccag gatttgaaag caggcagcct ggctccagac      120

cctgtgctct taactcccgt tttgcatcaa gaacagaatc ctatgaaagg cttgcacagt      180

gcttggtact gagatagcag catcaaggag cattgtgtac atgcagaagt gcacagtacc      240

tggagtgaaa ctgcttgtgt tcgatttctg ataccattca taactggctg tgtgatctca      300

aaacctctaa aatgcagacc tccagctcta gatctgtgca cctgagtgaa tggcagaaga      360

attacttcgc aattacatct ggcatatgta ccggaccgaa ggcagatgca taccgtgcac      420

agatattacg cattcagtat gcatgggcaa actctgagat ttcccaggtc tgtgctacca      480

aactgttcaa aaaatatgca gagaaatatt ctgcaattat tgattctgac aatgttgaat      540

ctgggttgaa taattatgca gaaaacattt taactttggc aggatctcaa caaacagata      600

gtgacaagtg gcagtctgga ttgtcaataa ataatgtttt caaaatgagt agtgtacaga      660

agatgatgca agctggcaaa aaattcaaag actctctgtt ggaacctgct cttgcatcag      720

tggtaatcca taaggaggcc actgtctttg atcttcctaa atttagtgtt tgtggtagtt      780

ctcaagagag tgactcatta cctaactcag ctcatgatcg agaccggacc caagacttcc      840

cggagagcaa tcgtttgaaa ctccttcaga atgcccagcc acctatggtg actaacactg      900

ctaggacttg tcctacattc tcagcacctg taggtgagtc agctactgca aaattccatg      960

tcacaccatt gtttggaaat gtcaaaaagg aaaatcacag ctctgcaaaa gaaaacatag     1020

gacttaatgt gttcttatct aaccagtctt gttttcctgc tgcctgtgaa aatccacaga     1080

ggaagtcttt ttatggttct ggcaccattg atgcactttc caatccaata ctgaataagg     1140

cttgtagtaa aacagaagat aatggcccaa aggaggatag cagcctgcct acatttaaaa     1200

ctgcaaaaga acaattatgg gtagatcagc aaaaaaagta ccaccaacct cagcgtgcat     1260

cagggtcttc atatggtggt gtaaaaaagt ctctaggagc tagtagatcc cgagggatac     1320

ttggaaagtt tgttcctcct atacccaagc aagatggggg agagcagaat ggaggaatgc     1380

aatgtaagcc ttatggggca ggacctacag aaccagcaca tccagttgat gagcgtctga     1440

agaacttgga gccaaagatg attgaactta ttatgaatga gattatggat catggacctc     1500

cagtaaattg ggaagatatt gcaggagtag aatttgctaa agccaccata aaggaaatag     1560

ttgtgtggcc catgttgagg ccagacatct ttactggttt aaggggaccc cctaaaggaa     1620

ttttgctctt tggtcctcct gggactggta aaactctaat tggcaagtgc attgctagtc     1680

agtctggggc aacattcttt agcatctctg cttcatcctt aacttctaaa tgggtaggtg     1740

agggggagaa aatggtccgt gcattgtttg ctgttgcaag gtgtcagcaa ccagctgtga     1800

tatttattga cgaaattgat tccttgttat ctcaacgggg agatggtgag catgaatctt     1860

ctagaaggat aaaaacagaa tttttagttc aattagatgg agcaacaaca tcttctgaag     1920

atcgtatcct agtggtggga gcaacaaatc ggccacaaga aattgatgag gctgcccgga     1980

gaagattggt gaaaaggctt tatattcccc tcccagaagc ttcagccagg aaacagatag     2040

taattaatct aatgtccaaa gagcagtgtt gcctcagtga agaagaaatt gaacagattg     2100

tacagcagtc tgatgcgttt tcaggagcag acatgacaca gctttgcagg gaggcttctc     2160

ttggtcctat tcgcagttta caaactgctg acattgctac cataacaccg gatcaagttc     2220

gacccatagc ttacattgat tttgaaaatg cttttagaac tgtgcgacct agtgtttctc     2280

caaaagattt agagctttat gaaaactgga acaaaacttt tggttgtgga aagtaagtgg     2340

gatacttgga atcaaggcat ctctgtagta cagtcttctt tattttttag catagaaagt     2400

tggggatgtg ttaattgtat ttttaagaat atattctaag ttctgtactt caaataatag     2460

cacagatttt acatctgatt gacatagtgt atgttaatgt aagttttgct ttccagtgat     2520

tacctgatac gtaagcctat ttgaacaaag tgagaatgaa cttttgtttc taagaagtct     2580

ttatcttgaa gctatataac atgaaaagtg agctcaaatt ttttttagtt gaagattaca     2640

tataaagttg tgtctgatta atattcatct tttattgaag aaagtgcctt ctgatggcca     2700

cataattctt aatgtcagct agtataatgg tttacatttg gacaaagtat tgcttagtgt     2760

tatttaagta gatttaagat ctcaaagcta aagtgccaat ttttactttc ttcagccaat     2820

ttgttacctc ttttatggtt tttaattttt atcaggacta acattttcag aaatagcaag     2880

gtgtgatcta gtattagatt cacagaactg aaaggttaat taagaatgtt ggttattttc     2940

acgggagcgt gtgatattta acattaatat tttatttgac actacagcct gtaatactgc     3000

tctctttcaa aaacaagttt tcagattttt ataacagacc cattttgttt tatgaaacat     3060

gttcattaca gaaacatgag aaaatagaga taagtaaaaa gaataaaagt cactattatc     3120

ctaccacttt gcgggacaca ctattaatat ttaagcatag attcttccag atgttttgtt     3180

ttatacagca gtaggattgt gtaatgtatt ctctcttgta gcctattctt caaagcgtat     3240

cttcactttc catgttaaca taaatgtcct tttatgattg tctaggattc catggatgga     3300

tggaatataa ttgagtcatc tggtagagcg catataggac aggacgctag gttgtttatc     3360

ttttgtttat tgtaaaggaa ctatgtggga tgcatttggt gatcttttta aaaaatgtat     3420

aaatttcttg agtaattcct ggattaaaga atatgcactt tttaaa                    3466


<210> 1395
<211> 2626
<212> DNA
<213> Homo sapiens

<400> 1395
gctgaaggct cggttcatgc cgtgcccccg ggcagttctg gtgaggctaa gcaagaggcc       60

tctgcatctt gacacctagg agagcaggga cggagtctcc cagggtggag gaccatgctg      120

cgccgcaagc cctccaatgc cagtgagaag gagcccactc agaagaaaaa gctctccctt      180

cagcgctcca gcagcttcaa ggattttgcc aaatccaaac ccagctcccc cgtggtgagc      240

gagaaggagt ttaatctgga tgataacatt ccagaagatg actcaggtgt ccccacccca      300

gaagatgctg ggaagagtgg caaaaagctg gggaagaagt ggagggcagt gatttcccga      360

accatgaaca ggaagatggg caagatgatg gtgaaggccc tgtcagaaga gatggcagac      420

actctggagg agggctctgc ctccccgaca tctccagact acagcctgga cagccctggc      480

cctgagaaga tggcgctggc cttttctgag caagaggagc atgaacttcc ggtgctcagc      540

cgccaggcat caacaggcag tgagctctgc agccccagcc caggttctgg cagcttcggg      600

gaggaaccac ctgcccccca gtacacaggg cctttctgtg gccgggcacg agtccacacc      660

gacttcactc ccagccccta tgaccacgac tcgctgaaac tgcagaaagg agatgtgatc      720

cagatcattg aaaagccacc tgtgggcacg tggctgggcc tactcaatgg caaggtgggc      780

tctttcaaat tcatctatgt ggatgtgctg cccgaggagg ccgtggggca tgcccgcccc      840

agccgccgac agagcaaggg caagaggccc aagcctaaga ccctgcatga gctgctggag      900

cgcatcggcc tggaggagca cacatccacc ctcctgctca atggctacca gacactggaa      960

gacttcaaag agctgcgaga aacacacctc aatgagctga acatcatgga tccacagcac     1020

cgggccaagc tgctcacggc cgccgagctg ctgctggact atgacactgg cagtgaggag     1080

gctgaagagg gcgccgagag cagccaggag ccagtggcac acacagtgtc ggaacccaag     1140

gtggacatcc cgcgcgactc aggctgcttt gagggctcgg agagcgggcg cgatgacgca     1200

gagctggcag gcactgagga gcagctgcaa ggcctctccc tggccggggc accttgaggt     1260

ggcggtggca ataggccaag gctgggaccc agctgcaaag gctgtaggag tgggcccagc     1320

ctcccgtggt ggcccaggtc ctgaggactg gcactgagcc tggccctgct tccccaggga     1380

cacttagggc cacagaggcc aggccagggc cctacaggtt ccaggctcag ctggagtggt     1440

tggggagtcg cccaagggca catcccacct gcctgagccc cgccctccac cagcgactga     1500

cagcgcagcc cctcctggca ccaactgctc ccctgccatg gccacggcca cagcaagtgg     1560

ggcactggga aaccctgccc atgtccctca ccaacaaggc ctccaaatcc tcctcacccc     1620

cacaccacct acccctgtcg cactgctcct gaaaaggggg ccaagtcaat gtttcaggtc     1680

agtctaaaaa ccctagggaa gctggccatt taaaagaacc caaactgacc atgggtaaat     1740

ccagttcccc taaataaggc ctgaagaaat ccacaggtac cattcccact ttccttctcc     1800

ctagctttct tagaggtttg gccactaaat cttatgagac ttgaaccaag tggcttcctc     1860

tttctaggct taggacgggt tggggttaga aagggtgatc actgaaggcc ttgcctgctc     1920

tgacattctg tgacattaaa tgtctattct cctgttacct gtggcctggg acaccagtgg     1980

ggtttatcga ggggaccaga ggggcctcag gctttcagat gaaatggctc ctcctactca     2040

cccactttat tcctctccat gtaattcagg acaagctgca acttccccca gcttaacaca     2100

atgcccatac ctcatacgat atgcgccctc ccgttccatc cctggccccc tcaaacgaga     2160

cttctcacaa ggctgattac agatggtcaa acctggcttc caaggacaga attgcctctc     2220

ggaagccagc tgtggatctg agtccagagt tggccacttg tgtgggtcct cacaagcaaa     2280

gagagcacta aacttgacat tgggggtcca ccactccaac tttgctttct gaaggttttg     2340

gtgtacattg agccccagaa ggaaaggaga gtatctgtga gtgggggcct cccttgaccc     2400

cagtacgaag tctatgccct gaatccccag agtagccctt cctggtgccc aactggcctg     2460

gggacaaaca gcgtccacta catctaggac tgccggctaa gtggacacac ttcttgacct     2520

cctaccagga actttggtaa aagctagctt tggggaaggg gttgggtgta aatatgagag     2580

ggtggaggga gaccagctgg tagcaataaa catgggtaga actaaa                    2626


<210> 1396
<211> 2680
<212> DNA
<213> Homo sapiens

<400> 1396
cctgctcctg caccggtctg catctcccag cagaaggcgc agccatgaat ccgttattcg       60

gccccaacct cttcctcctg cagcaggagc agcagggcct ggccgggcca ctgggggact      120

cactgggagg cgaccacttc gccgggggag gagacttgcc cccggcgcct ctctcgccgg      180

ccggccctgc tgcctactcg ccgcccgggc cgggcccggc cccgcctgcc gccatggccc      240

tccgcaatga cctgggctcc aacatcaacg tgctcaagac cctgaacctc cggttccgct      300

gcttcctggc caaggtgcat gagctggagc gccggaaccg gctgttggag aagcaactgc      360

agcaagcgct ggaggagggt aagcagggcc ggcggggcct gggtcgtcgc gaccaggcag      420

tgcagaccgg cttcgtcagc cccatccggc ccctggggct gcagctgggc gcccggccgg      480

ccgctgtctg cagcccttcg gcgcgcgtgc tgggctcgcc cgcgcgctcc ccggccggcc      540

ccctcgcgcc ctccgcggcc agcctctcgt cgtcctccac ctccacctcc accacctatt      600

cctcgtcggc ccgcttcatg cccggcacca tctggtcgtt ctcgcacgcc cgccggctcg      660

ggccgggact ggagcccact ctggtgcaag ggcctggctt gtcgtgggtg cacccggatg      720

gggtgggcgt ccagatcgac accatcacgc ccgagatccg cgctctctac aacgtgctgg      780

ccaaagtgaa gcgggagcgg gacgagtaca agcggaggtg ggaagaggag tacacggtgc      840

ggatccagct gcaagaccgt gtaaatgagc tccaggagga agcccaggag gctgatgcct      900

gccaggagga gctggcactg aaggtggaac agttgaaggc tgagctggtg gtcttcaagg      960

ggctcatgag taacaacctg tcggagctgg acaccaagat ccaggagaaa gccatgaagg     1020

tggatatgga catctgccgc cgcatcgaca tcaccgccaa gctctgcgat gtggctcagc     1080

agcgcaactg cgaggacatg atccagatgt tccagaagaa gctggtccca tccatggggg     1140

ggcggaagcg ggagcgcaag gctgccgtcg aggaggacac ctccctgtcg gagagtgagg     1200

ggccccgcca gcccgatggg gatgaggagg agagcacagc cctcagcatc aacgaggaga     1260

tgcagcgcat gctcaaccag ctgagggagt atgattttga ggacgactgt gacagcctga     1320

cttgggagga gactgaggag accctgctgc tttgggagga tttctcaggc tatgccatgg     1380

cagctgcaga ggcccaggga gagcagcagg aagatagcct ggagaaggtg attaaagata     1440

cggagtccct gttcaaaacc cgggagaagg agtatcagga gaccattgac cagatagagc     1500

tggagttggc cacggccaag aacgacatga accggcacct gcacgagtac atggagatgt     1560

gcagcatgaa gcgcggcctg gacgtgcaga tggagacctg ccgccggctc atcacccagt     1620

ctggagaccg aaagtctcct gctttcactg cggtcccgct tagcgacccg ccgccgccgc     1680

caagcgaggc tgaggactcc gatcgcgatg tctcatctga cagctccatg agatagagac     1740

ctgcctcccc cttgcacccg aggccctcgc agcagggagc tcagcgaggc agagggtggg     1800

gctgcacaga ggggaacatc agctgcagct ctgcaccagg ccggtccctg gggactgggg     1860

cgctcctccc tcaggctttc tccctcagtc ttggcttctc cagggctctg gggtgtctgg     1920

agctaggctt ggccctacca ttctggggcc atttccacca cagttggggc tctcctgcct     1980

tcacgcgtgg gtgtctgcta cttccccatc tttaaaatgc tgccagagcg attgcggccc     2040

ctcaccttgt ccacgtatca ggaatgtgaa tgtgggacct ttcctccatc cctgttgtcc     2100

ggagccagct cactgtcttc cacactggtg ctaactggcc caggcactgg agtggaatag     2160

aatgcagctg gaggctacgc atggcctctg cagcacacgc agctggagag ggcttctgtc     2220

cctgtcagcg gcagagggcg ttggggctgg ccggggcacc ttgtccctgc tatggtccac     2280

gtgctcacgc tgtccacctg ccaggtggag tgtatgtggc tgtggccctc cctcgtggag     2340

gtgccgtgct ttaaagaggc cttagtgccc gggatgggca cagtgttttg aagggaggtg     2400

ggagctcttg ctctcctggt cactgcagaa tgacagagaa ggtgaagctc catgcatgtg     2460

tgcgcgggtg tatgtgcgct cagggtctct gtttaagtat cagctaaaga tgtgcttcct     2520

ccgtgtctgt catacactga gaccaacagg ctacagtgtc cctgattctt ggaaaagcct     2580

ggagaagctg gggagatgcg gttcacaatg cctcggtata ggaggctgtg ttgagctgac     2640

attcaaatgg attctttaat aataatgaaa ctggcgagta                           2680


<210> 1397
<211> 2264
<212> DNA
<213> Homo sapiens

<400> 1397
gatggaatag cattgaccca gtttacaaag ccatctgaag tgcctgagtt gtatttgaag       60

ggtttcacca tgttggccag gctggtctca aactcctgac ctcaagtgat ctgcccacct      120

cagcctccca aagtgttggg attacaggcg tgagccacca cacccagcca agagatactt      180

cttgaatagt tttattctgt atctacttga aatataagtg aactttttgt ttatttggaa      240

tgcttttctt ggcaatccca cagagtattg atgaggaaac tgaagtttgg agcgatcaca      300

tcattttccc aagaattcct agaggacctg tgcaacaacc tcttgaggat cgaatcttca      360

ctcccgctgt ctcagcagtc tacagcacgg taacacaagt ggcaagacag ccgggaaccc      420

ctaccccatc cccttattca gcacatgaaa taaacaaggg gcatccaaat cttgcggcaa      480

cgcccccggg acatgcatcg tcccctggac tctctcaaac cccttatccc tctggacaga      540

atgcaggtcc aaccacgctg gtataccctc aaacccctca gacaatgaat tcacaacctc      600

aaacccgttc tccgtttgca gcggggcctc gacctcccca tcatcagttt ttccagaggc      660

ctcaaataca gcctcctaga gctaccatcc cgaacagcag tccttccatt cgtcctggtg      720

cacagacacc cactgcagtg taccaggcta atcagcacat catgatggtt aaccatctgc      780

ccatgccgta cccagtgccc caggggcctc agtactgtat accacagtac cgtcatagtg      840

gccctcctta tgttgggccc ccccaacaat atccagttca accaccgggg ccaggtcctt      900

tttatcctgg accaggacct ggggacttcc ccaatgctta tggaacgcct ttttacccaa      960

gtcagccggt gtatcagtca gcacctatca tagtgcctac gcagcaacag ccgcctccag     1020

ccaagagaga gaaaaaaact ataagaattc gggatccaaa ccagggaggt aaagacataa     1080

cagaggagat tatgtctgga ggtggcagca gaaatcctac tccacccata ggaagaccca     1140

cgtccacacc tactcctcct cagcagctgc ccagccaggt ccccgagcac agccctgtgg     1200

tttatgggac tgtggagagc gctcatcttg ctgccagcac ccctgtcact gcagctagcg     1260

accagaagca agaggagaag ccaaaaccag atccagtgtt aaagtctcct tccccagtcc     1320

ttaggctagt cctcagtgga gagaagaaag aacaagaagg ccagacatct gaaactactg     1380

caatagtatc catagcagag cttcctctgc ctccatcacc taccactgtt tcttctgttg     1440

ctcgaagtac aattgcagcc cccacctctt ctgctcttag tagccaacca atattcacca     1500

ctgctataga tgacagatgt gaactctcat ccccaagaga agacacaatt cctataccca     1560

gcctcacatc ttgcacagaa acatcagacc ctttaccaac aaatgaaaat gatgatgata     1620

tatgcaagaa accctgtagt gtagcaccta atgatattcc actggtttct agtactaacc     1680

taattaatga aataaatgga gttagcgaaa aattatcagc cacggagagc attgtggaaa     1740

tagtaaaaca ggaagtattg ccattgactc ttgaattgga gattctcgaa aatcccccag     1800

aagaaatgaa actggagtgt atcccagctc ccatcacccc ttccacagtt ccttcctttc     1860

ctccaactcc tccaactcct ccagcttctc ctcctcacac tccagtcatt gttcctgctg     1920

ctgccactac tgttagttct ccgagtgctg ccatcacagt ccagagagtc ctagaggagg     1980

acgagagcat aagaacttgc cttagtgaag atgcaaaaga gattcagaac aaaatagagg     2040

tagaagcaga tgggcaaaca gaagagattt tggattctca aaacttaaat tcaagaagga     2100

gccctgtccc agaaacatcg aatgaatgct gaaattccta gtctggtttc ttcagtggtg     2160

tgtttgtgtt ttagtacaac ctgcaaaaga gttactccat tgtctaaaaa tgcaaatgag     2220

aatttccaaa tatacaaaat gcctccaagg tatatgtcac gaaa                      2264


<210> 1398
<211> 2437
<212> DNA
<213> Homo sapiens

<400> 1398
gccttctggc agtttctggg agctgcgaac gcgccgcccc ggggctcggc ggccggaaac       60

gctggcttcg gagccttagg cgccgcggcc tttccttgtt ttccgcccag tccacgccgc      120

catggccaag tggggccagg ggaaccccca ctggatcgtg gaggagcggg aggacgggac      180

caacgtgaac aactggcgct ggcgcggctg gcggcggcct ccttccggga tctggggagg      240

gccgggccgc gggagccggg gctgccctgg ggtctgtgcg gggccgcggg gccagggggt      300

cagggggccg ccccccctca gctgctggac gcagggctcg gccttcgcct ctcggctcgg      360

gagagtcctt gagtacggag accggctagg agggttgcag ctgcctcttt ttgaaagttg      420

ggttgggccc caagagtgac ttccgacaga cctttccact cccaccgtct gtggcctgag      480

ggccttccct tctcctcccg cccacccctc tggatgtttc ggggagttag aagggagctg      540

gattgagaga ctgtgttagg ggcgggggta tggaacgtag tggaaagggc agaaatttgg      600

atctcagttc gcgcccaccc cgcaggcgcc tcccgcgagc cgggccctct gtgagtgaga      660

caagctcccc ttcctttacg cgcctcacct ggcgcgtggg gagaggtcgg cagccctccg      720

ccgcagaacc tccggaaggg atgtcctctg ccctgcgcct ctggccgggg ctgtggtccc      780

tccaggccgt cgaggggatg ctgaggccgg tccccagagg agcatgactt ggctggtccg      840

gaggagctct gagggcatgg gcaatcttgg ctcgctgcaa cctcagcttc cagagttcaa      900

gcgagtctcc tgcttcagcc tcatgagtag ctgggactac agatgcgtgc cactacgtcc      960

gtctgatgac agagcgggat gccaccagct tgtccaaagg gaagttccag gagctcctgg     1020

tgggcatcgt tgtggagaat gacgctggcc gcggcgagat caacgagttg aagcaggtgg     1080

aaggggaggc ttcgtgcagc agccgcaaag gaaagctgat tttcttctat gagtggaaca     1140

tcaaactggg ctggaaaggc atcgttaaag aatctggagt gaagcacaag ggattgattg     1200

aaatacccaa tctttctgag gaaaatgaag tagatgacac tgagaattta caacgggaat     1260

gattttacca acgaaagcta tggcaaccca ggaattgact gtcaaaagaa aactgagtgg     1320

gaataccctg caggttcagg cctcatctcc agtggcactg ggtgtaagga ttcccactgt     1380

ggctcttcac atgatggaac tgtttgacac aactgtagag cagctgtata gcatcttcac     1440

tgtaaaggag ttaacaaata agaagatcat catgaaatgg agatgtggga actggccaga     1500

agaacactat gccatggttg cactgaattt tgtgcctact ctagggcaaa cagaattaca     1560

attgaaggag ttcctatcta tctgtaaaga agagaacatg aaattctgtt ggcagaagca     1620

gcattttgaa gaaataaaag gttcactgca gctgaccccc ctaaatggtt gaattaaaat     1680

ttattataag gcattacttt ttgtaagcgg aaaaagtgtc acatttacct cttccctatc     1740

ttttgtttaa aaggactgtc tttattttat attggatgaa atctatgaac atatatacaa     1800

tgtaaagcat tgtttgactc tttattataa ctagacactg cattgattta aaagtagcaa     1860

acaacctgaa attaagtatt aacctgacct tccatcgata ttcctctgga aataggtaag     1920

tcctgagtgc agatagttga tgtttcccaa gctgaagctt gtcctatagc aagcttgctt     1980

gcagctgtac ttttagttca agatgacaaa aaataaatgg catgttgaca ctattccttt     2040

attttacttt agggttttta aggtgtgtag atcttaggtc gtaaaacagt ggtatattgc     2100

attcaaaagc atgttgaggt gagggcaaat tggctgtgtt ttgctccaca tctccctgca     2160

catctccctg ctgtggtttt gcacttcggt gtggagagga ttgagaagtc tgtggggaca     2220

cattagttct gtggactgct ggtaacactt ccagtgaaac agcatataat ggataaatgt     2280

ttcccccctc tttcacggtt ttctcactac tttcacctga gaagactgaa gcaacgtatg     2340

taaacaaatg aaaagtcatc acaatcagtt taattaagtg cacagaatag caatcaatca     2400

atcagtcatg tcaataaaaa taaaacaatt attttta                              2437


<210> 1399
<211> 2617
<212> DNA
<213> Homo sapiens

<400> 1399
cggttcccgt agccttagct ctcggccccg ggcccttttt cctcctcggc tgcgccgcgt       60

gtcctcggag cgcggtccct gtattggtct cctgctccta gaggttgaga acaaaaacat      120

gcacctggag tttccccgga gccctctgcg tggttgagct tcggtggaat ttcggggctc      180

ttggctgcca gccgcgcttg cctggtagca acagaaacca gtcctgctcg cctccgtgga      240

catttcatta ccatccagaa gtgtctccca ctgaaggcat ccgtggttgt ttttaagcca      300

caaaaaagcc acacccaaga tcacctgaca cccaccctga caagtgtcca tgatgctggg      360

ccctgaggga ggtgaaggct ttgtggtcaa gctccgtggc ctgccctggt cctgctctgt      420

tgaggacgtg cagaacttcc tctctgactg cacgattcat gatggggccg caggtgtcca      480

tttcatctac actagagagg gcaggcagag tggtgaggct tttgttgaac ttggatcaga      540

agatgatgta aaaatggccc tgaaaaaaga cagggaaagc atgggacacc ggtacattga      600

ggtgttcaag tcccacagaa ccgagatgga ttgggtgttg aagcacagtg gtcccaacag      660

tgccgacagc gccaacgatg gcttcgtgcg gcttcgagga ctcccatttg gatgcacaaa      720

ggaagaaatt gttcagttct tctcagggtt ggaaattgtg ccaaacggga tcacattgcc      780

tgtggacccc gaaggcaaga ttacagggga agcgttcgtg cagtttgcct cgcaggagtt      840

agctgagaag gctctaggga aacacaagga gaggataggg cacaggtaca ttgaggtgtt      900

taagagcagc caggaggaag ttaggtcata ctcagatccc cctctgaagt tcatgtccgt      960

gcagcggcca gggccctatg accggcccgg gactgccagg aggtacattg gcatcgtgaa     1020

gcaggcaggc ctggaaagga tgaggcctgg tgcctacagc acaggctacg ggggctacga     1080

ggagtacagt ggcctcagtg atggctacgg cttcaccacc gacctgttcg ggagagacct     1140

cagctactgt ctctccggaa tgtatgacca cagatacggc gacagtgagt tcacagtgca     1200

gagcaccaca ggccactgtg tccacatgag gggcctgccg tacaaagcga ccgagaacga     1260

catttacaac ttcttctctc ctctcaaccc tgtgagagtc catattgaga ttggcccaga     1320

tggaagagtg acgggtgaag cagatgttga gtttgctact catgaagaag ctgtggcagc     1380

tatgtccaaa gacagggcca atatgcagca cagatatata gaactcttct tgaattcaac     1440

aacaggggcc agcaatgggg cgtatagcag ccaggtgatg caaggcatgg gggtgtctgc     1500

tgcccaggcc acttacagtg gcctggagag ccagtcagtg agtggctgtt acggggccgg     1560

ctacagtggg cagaacagca tgggtggcta tgactagttt tgttaggaac atttgagtta     1620

cttcaatcat tttcacaggc agccaacaag caattaagag cagttataat agaggaagct     1680

gggggaccca ttttgcacca tgagtttgtg aaaaatctgg attaaaaaat tacctcttca     1740

gtgttttctc atgcaaaatt ttcttctagc atgtgataat gagtaaacta aaactatttt     1800

cagcttttct caattaacat tttggtagta tacttcagag tgatgttatc taagtttaag     1860

tagtttaagt atgttaaatg tggatctttt acaccacatc acagtgaaca cactggggag     1920

acgtgctttt ttggaaaact caaaggtgct agctccctga ttcaaagaaa tatttctcat     1980

gtttgttcat tctagtttat attttcattt aaaatccttt aggttaagtt taagcttttt     2040

aaaagttagt tttgagaatt gagacacaat actaatactg taggaattgg tgaggccttg     2100

acttaaaact ttctttgtac tgtgatttcc ttttgggtgt attttgctaa gtgaaacttg     2160

ttaaattttt tgttaactaa atttttttct taaaataaag actttttcac aatgactggc     2220

acagattact cagcaaaaga tagcaaaacg ggtggttgaa gataattcat tttaatcgta     2280

atgtatttta gtgtgaattt aaaaatttca tacatcaaat ctatgatctc ccttatattc     2340

ttatgatgag gctaaataaa agtctaataa aaatgttaaa tatgtgaatg gtggaaatgg     2400

tgactagcag cacacattct gggaagcatc aaatagacac acggccccag ccacctgcaa     2460

cttatgtgca ctgttgtaaa ccattcagaa ttttcctgct aggcccttga tgctggagtc     2520

acatctgttg atagctggag aactttagtt tcaagtacta cattgtgaaa gcaattattt     2580

tgtttctagt ttttataaaa tgctgattta aactttt                              2617


<210> 1400
<211> 1555
<212> DNA
<213> Homo sapiens

<400> 1400
acaagatggc ggcgctgcgg gacggctagc ggccctgcgt gggagttcct gacagctgga       60

ttctagaagt agaactatga gctcaccttt ggcctccctt agcaagaccc gaaaagtgcc      120

cctgccctcg gagcctatga atcctgggag gcgaggaatc cgcatctatg gagatgtccc      180

tgcatcccat gactcggagc tgatggcctt catgacgagg aagttgtggg acctggagca      240

gcaggtgaag gcccagactg atgagatact gtccaaggat cagaagatag cggccctaga      300

ggacctggtg cagaccctcc ggccacaccc agccgaggca accctgcagc ggcaggagga      360

actggagacg atgtgtgtgc agctgcagcg gcaggtcagg gagatggagc ggttcctcag      420

tgactatggc ctgcagtggg tgggcgagcc catggaccag gaggactcag agagcaagac      480

agtctcagag catggcgaga gggactggat gacagccaag aagttctgga agccagggga      540

ctcattggcg ccccctgagg tggactttga caggctgctg gccagcctgc aggatcttag      600

tgagctggtg gtagagggtg acacccaagt gacaccagtg cccggcgggg cacggctgcg      660

taccctcgag cccatcccgc tgaagctcta ccggaatggc atcatgatgt tcgacgggcc      720

cttccagccc ttctacgatc cctccacaca gcgctgcctc cgagacatat tggatggctt      780

ctttccctca gagctccagc gactgtaccc caatggggtc ccctttaagg tgagtgactt      840

gcgcaatcag gtctacctgg aggatggact ggaccccttc ccaggcgagg gccgtgtggt      900

gggcaggcag ctgatgcaca aggccttgga cagggtggag gagcacccag gctccaggat      960

gactgctgag aaatttctga acaggctccc caagtttgtg atccggcaag gcgaggtgat     1020

tgacatccgg ggccccatca gggacacctt gcagaactgc tgcccattgc ctgcccggat     1080

ccaggagatt gtggtggaga cgcccacctt ggccgctgag cgagagagga gccaggagtc     1140

acccaacacg ccggcacccc cgctctccat gctgcgcatc aagtctgaga atggggaaca     1200

ggccttccta ctgatgatgc agcctgacaa caccattggg gacgtgcgag ctctgctagc     1260

gcaggccagg gtcatggatg cctctgcctt tgagatcttc agcacattcc cgcccaccct     1320

ctaccaggac gatacactca cgctgcaggc tgcaggcctt gtgcccaaag cagcactgct     1380

gctgcgggca cgccgagccc cgaagtccag cctgaaattc agtcctggtc cctgtcccgg     1440

tcccggtccc ggccccagtc ccggtcccgg tcccggcccc agtcccggtc ccggtcccgg     1500

ccccagtccc tgtcctggac ccagtcccag cccccaataa agcacccgcc ccctc          1555


<210> 1401
<211> 1662
<212> DNA
<213> Homo sapiens

<400> 1401
gctgcgggct ccgcgcgcgc gggccatgtc cgctttctgc ctgggcttgg tcggccgcgc       60

ttcagcaccc gccgagccgg acagcgcctg ctgcatggag ctgcccgccg cggccgggga      120

cgcagtccgg agtcccgccg ccgccgccgc cctcatcttc cccgggggct ccggggagct      180

agaactggcg ttagaggagg agctggcgct gctggcggcc ggggagcggc cgtccgaccc      240

cggggaacac cctcaggccg agctgctgtc ggtgatccga cagaaggaga aggatctggt      300

gttggcggcc cggctgggta aggcgctgct cgagaggaac caggacatga gccggcagta      360

cgagcagatg cataaggagc tgacagacaa gctcgagcac ttagagcaag agaaacatga      420

attgagaaga cgatttgaga accgagaagg ggagtgggaa ggccgagtgt cagagctgga      480

gagtgatgtg aagcagctac aggatgagtt ggagaggcag cagattcatc tgcgggaagc      540

agatcgagaa aaatcacggg ctgtccagga actgtcggaa cagaaccaaa ggctattgga      600

tcagctcagc agggcatcag aagttgagag acaactctcc atgcaggtcc acgccctcag      660

agaagacttt cgggagaaaa actcatcaac caaccagcac attatccggc tggagagcct      720

tcaggccgag atcaagatgc tgtcagatcg gaaacgggag ctggagcatc gtctcagcgc      780

tactttagag gaaaatgacc tgctccaagg gaccgtggag gagctacagg accgggtgct      840

aatcctggag aggcagggcc atgacaagga cctacagctg caccaaagcc agctggagct      900

tcaggaggtg cgtctctcct gccgacagct gcaggtgaag gtggaagaac tcactgagga      960

gaggagtctg cagagctctg ccgccaccag cacatccctc ctgtcagaga tcgagcagag     1020

catggaggct gaggagctgg agcaggagcg agagcagctg agactgcagc tctgggaagc     1080

ctactgccag gttcgctatc tgtgctcaca ccttcgaggc aatgacagtg ctgactcagc     1140

cgtctccacg gactcctcca tggacgagtc ttcagaaacc tcgtccgcca aggatgtgcc     1200

agccggcagc ttgcgcactg ccctcaatga gctcaagaga ctgatacaga gcattgtgga     1260

tggcatggag cccacgggct cccggagact tgatgatgac tccttagaag aacagataag     1320

gcagaccagt gaggactcga gagccctaag ggagctcatg gagggagaga gggggaggct     1380

gccggaagcc tccagatgct gcctgcctgc ctgctcacaa ccgattcagt ctccctccct     1440

ccctcacgtg gggaaagcac agcagggatg cgcggcaaga atgtacctgt agatgtgtac     1500

ataccacagt gctgtaattt tgtatgtagc aatcatgtaa atacatgtat ggattttata     1560

atatacatat ataaaaatct ataaaggcat atttttagaa aaacagcaca ccactgcttc     1620

ttttgaaaat agtctgaata agaataaaat gaatttctac ag                        1662


<210> 1402
<211> 1428
<212> DNA
<213> Homo sapiens

<400> 1402
atgacacgtg gcaccggggg aactgcccag cgtggaaggt ctgggccaga ttctcagggg       60

ctgctagatt catccctgat ggcatcaggc actgccagcc gctcagagga tgaggagtca      120

ctggcagggc agaagcgagc ctcctcccag gccttgggca ccatccctaa acggagaagc      180

tcctccaggt tcatcaagag gaagaagttc gatgatgagc tggtggagag cagcctggca      240

aaatcttcta cccgggcaaa gggggccagt ggggtggaac cagggcgctg ttcggggagt      300

gaaccctcct ccagtgagaa gaagaaggta tccaaagccc ccagcactcc tgtgccaccc      360

agcccagccc cagcccctgg actcaccaag cgtgtgaaga agagtaaaca gccacttcag      420

gtgaccaagg atctgggccg ctggaagcct gcagatgacc tcctgctcat aaatgctgtg      480

ttgcagacca acgacctgac ctccgtccac ctgggcgtga aattcagctg ccgcttcacc      540

cttcgggagg tccaggagcg ttggtacgcc ctgctctacg atcctgtcat ctccaagttg      600

gcctgtcagg ccatgaggca gctgcaccca gaggctattg cagccatcca gagcaaggcc      660

ctgtttagca aggctgagga gcagctgctg agcaaagtgg gatcgaccag ccagcccacc      720

ttggagacct tccaggacct gctgcacaga caccctgatg ccttctacct ggcccgtacc      780

gcgaaggccc tgcaggccca ctggcagctc atgaagcagt attacctgct ggaggaccag      840

acagtgcagc cgctgcccaa aggggaccaa gtgctgaact tctctgatgc agaggacctg      900

attgatgaca gtaagctcaa ggacatgcga gatgaggtcc tggaacatga gctgatggtg      960

gctgaccggc gccagaagcg agagattcgg cagctggaac aggaactgca taagtggcag     1020

gtgctagtgg acagcatcac aggcatgagc tctccggact tcgacaacca gacactggca     1080

gtgctgcggg gccgcatggt gcggtacctg atgcgctcgc gtgagatcac cctgggcaga     1140

gcaaccaagg ataaccagat tgatgtggac ctgtctctgg agggtccggc ctggaagata     1200

tcccggaaac aaggtgtcat caagctgaag aacaacggtg atttcttcat tgccaatgag     1260

ggtcgacggc ccatctacat cgatggacgg ccggtgctct gtggctccaa atggcgcctc     1320

agcaacaact ctgtggtgga gatcgccagc ctgcgattcg tcttccttat caaccaggac     1380

ctcattgccc tcatcagggc tgaggctgcc aagatcacac cacagtga                  1428


<210> 1403
<211> 2437
<212> DNA
<213> Homo sapiens

<400> 1403
ctgagcgggt gcgcgggcaa cttccggtgt gggtgacgag tggtggccga agcaggggga       60

cagcaaggga cgctcaggcg gggaccatgg cggacggcgg ctcggagcgg gctgacgggc      120

gcatcgtcaa gatggaggtg gactacagcg ccacggtgga tcagcgccta cccgagtgtg      180

cgaagctagc caaggcttcc gatatggtat cgacatcccg tatcttagtt gcagtagtga      240

agatgtgcta tgaggctaaa gaatgggatt tacttaatga aaatattatg cttttgtcca      300

aaaggcggag tcagttaaaa caagctgttg ccaaaatggt tcaacagtgc tgtacttatg      360

ttgaggaaat cacagacctt cctatcaaac ttcgattaat tgatactcta cgaatggtta      420

ccgaaggcaa gatttatgtt gaaattgagc gtgcgcgact gactaaaaca ttagcaacta      480

taaaagaaca aaatggtgat gtgaaagagg cagcctccat tttacaggag ttacaggtgg      540

aaacctacgg gtcaatggaa aagaaagagc gagtggaatt tattttggag caaatgaggc      600

tctgcctagc tgtgaaggat tacattcgaa cacaaatcat cagcaagaaa attaacacca      660

aatttttcca ggaagaaaat acagagaaat taaagttgaa gtactataat ttaatgattc      720

agctggatca acatgaggga tcctatttgt ctatttgtaa gcactacaga gcaatatatg      780

atactccctg tatacaggca gaaagtgaaa aatggcagca ggctctgaag agtgttgtac      840

tctatgttat cctggctcct tttgacaatg aacagtcaga tttggttcac cgaataagtg      900

gtgacaagaa gttagaagaa attcccaaat acaaggatct tttaaagctt tttaccacaa      960

tggagttgat gcgttggtcc acacttgttg aggactatgg aatggaatta agaaaaggtt     1020

cccttgagag tcctgcaacg gatgtttttg gttctacaga ggaaggtgaa aaaaggtgga     1080

aagacttgaa gaacagagtt gttgaacata atattagaat aatggccaag tattatactc     1140

ggataacaat gaaaaggatg gcacagcttc tggatctatc tgttgatgag tccgaagcct     1200

ttctctcaaa tctagtagtt aacaagacca tctttgctaa agtagacaga ttagcaggaa     1260

ttatcaactt ccagagaccc aaggatccaa ataatttatt aaatgactgg tctcagaaac     1320

tgaactcatt aatgtctctg gttaacaaaa ctacgcatct catagccaaa gaggagatga     1380

tacataatct acaataaggg tcttagtgct ttagaaaaaa gttaaaattg gaagtcatta     1440

aaaaaagact gttataatgg tgtatatgtt ggggtttttt ttctaagctt ctttgtctta     1500

aattttaaaa tagtgaatat gtttgagact ccctttgacc tttcagttcc ccaagttcat     1560

tgttaacttt gcatttgcaa ttggtgcaaa aatacagatt tctgtcgtct gaatacacaa     1620

aaagttgtgt cataacttac ccagatatgt ttttctatca tttgaaacct ttttagctac     1680

tgtttgtttt cattcaacta acaaacatat tccaataata aaagcagtat atacatattt     1740

cctttctaca gttacctctg attctcaaca ttttgtgggg tagtgatttg gcaagtgttt     1800

tttaaataaa acaaatctca ttgtaaagct atcagtcatt tagtagaata gaaaagcaac     1860

atagagcata caagaacatt tgggatagag ttgtgatttg tgaagaattt gtactttgat     1920

attgtggcgg aaagtctaga ctgagtgtgt atgctggtaa actgtagact tttttttttt     1980

tttttttgag tccggctggt tccaatcaca gtagcttgat tgctttcagc cctcatcctc     2040

tcacttgatc agttgttcaa cagaatcagc tgacataatt gacacagttt attgggtgtt     2100

aagtccgctc tatagggata gtgactactt tttttttttt tttttttttg ctcttcttcc     2160

tctccccttt ctttatatgg gtttaaattt aacataaagt tgtttttata aggcttattt     2220

gtggctttaa cttgtaagtc tgattacatc attattgttc caaattcatt atctctgtag     2280

gaacttttag ttccattata tgaacactgg ataacctaat tttttttaat gctttaaaaa     2340

aatggcaaaa agacgtcagg ccaccctcat agtaagtggt gtagtattaa aatattttca     2400

cggaattaaa agtagcttgc tgtcaaagaa acacctg                              2437


<210> 1404
<211> 1999
<212> DNA
<213> Homo sapiens

<400> 1404
agcgcgagcc ccgccgccgc cgagcatgga cgaccccgac tgcgactcca cctgggagga       60

ggacgaggag gatgcggagg acgcggagga cgaggactgc gaggacggcg aggccgccgg      120

cgcgagggac gcggacgcag gggacgagga cgaggagtcg gaggagccgc gggcggcgcg      180

gcccagctcg ttccagtcca gaatgacagg gtccagaaac tggcgagcca cgagggacat      240

gtgtaggtat cggcacaact atccggatct ggtggaacga gactgcaatg gggacacgcc      300

aaacctgagt ttctacagaa atgagatccg cttcctgccc aacggctgtt tcattgagga      360

cattcttcag aactggacgg acaactatga cctccttgag gacaatcact cctacatcca      420

gtggctgttt cctctgcgag aaccaggagt gaactggcat gccaagcccc tcacgctcag      480

ggaggtcgag gtgtttaaaa gctcccagga gatccaggag cggcttgtcc gggcctacga      540

gctcatgctg ggcttctacg ggatccggct ggaggaccga ggcacgggca cggtgggccg      600

agcacagaac taccagaagc gcttccagaa cctgaactgg cgcagccaca acaacctccg      660

catcacacgc atcctcaagt cgctgggtga gctgggcctc gagcacttcc aggcgccgct      720

ggtccgcttc ttcctggagg agacgctggt gcggcgggag ctgccggggg tgcggcagag      780

tgccctggac tacttcatgt tcgccgtgcg ctgccgacac cagcgccgcc agctggtgca      840

cttcgcctgg gagcacttcc ggccccgctg caagttcgtc tgggggcccc aagacaagct      900

gcggaggttc aagcccagct ctctgcccca tccgctcgag ggctccagga aggtggagga      960

ggaaggaagc cccggggacc ccgaccacga ggccagcacc cagggtcgga cctgtgggcc     1020

agagcatagc aagggtgggg gcagggtgga cgaggggccc cagccacgga gcgtggagcc     1080

ccaggatgcg ggacccctgg agaggagcca gggggatgag gcagggggcc acggggaaga     1140

taggccggag cccttaagcc ccaaagagag caagaagagg aagctggagc tgagccggcg     1200

ggagcagccg cccacagagc caggccctca gagtgcctca gaggtggaga agatcgctct     1260

gaatttggag gggtgtgccc tcagccaggg cagcctcagg acggggaccc aggaagtggg     1320

cggtcaggac cctggggagg cagtgcagcc ctgccgccaa cccctgggag ccagggtggc     1380

cgacaaggtg aggaagcgga ggaaggtgga tgagggtgct ggggacagtg ctgcggtggc     1440

cagtggtggt gcccagacct tggcccttgc cgggtcccct gccccatcgg ggcaccccaa     1500

ggctggacac agtgagaacg gggttgagga ggacacagaa ggtcgaacgg ggcccaaaga     1560

aggtacccct gggagcccat cggagacccc aggccccagc ccagcaggac ctgcagggga     1620

cgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga     1680

cgagccagcc gagagcccat cggagacccc aggccccagc ccggcaggac ctacaaggga     1740

tgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga     1800

cgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga     1860

cgagccagcc gagagcccat cggagacccc aggccccagc ccggcaggac ctacaaggga     1920

tgagccagcc aaggcggggg aggcagcaga gttgcaggac gcagaggtgg agtcttctgc     1980

caagtctggg aagccttaa                                                  1999


<210> 1405
<211> 1705
<212> DNA
<213> Homo sapiens

<400> 1405
agaggcagag acacacgcgg agaggaggag aggctgaggg agggaggtgg agaaggacgg       60

gagaggcaga gagaggagac acgcagagac actcaggagg ggagagacac cgagacgcag      120

agacactcag gaggggagag acaccgagac gcagagacac ccaggccggg gagcgcgccc      180

tcccctcggc gggcacggta tttttatccg tgcgcgaaca gccctcctcc tcctctcgcc      240

gcacagcccg ccgcctgcgc gggggagccc agcacagacc gccgccggga ccccgagtcg      300

cgcaccccag ccccaccgcc caccccgcgc gccatggacc ccaaggaccg caagaagatc      360

cagttctcgg tgcccgcgcc ccctagccag ctcgaccccc gccaggtgga gatgatccgg      420

cgcaggagac caacgcctgc catgctgttc cggctctcag agcactcctc accagaggag      480

gaagcctccc cccaccagag agcctcagga gaggggcacc atctcaagtc gaagagaccc      540

aacccctgtg cctacacacc accttcgctg aaagctgtgc agcgcattgc tgagtctcac      600

ctgcagtcta tcagcaattt gaatgagaac caggcctcag aggaggagga tgagctgggg      660

gagcttcggg agctgggtta tccaagagag gaagatgagg aggaagagga ggatgatgaa      720

gaagaggaag aagaagagga cagccaggct gaagtcctga aggtcatcag gcagtctgct      780

gggcaaaaga caacctgtgg ccagggtctg gaagggccct gggagcgccc accccctctg      840

gatgagtccg agagagatgg aggctctgag gaccaagtgg aagacccagc actaagtgag      900

cctggggagg aacctcagcg cccttccccc tctgagcctg gcacataggc acccagcctg      960

catctcccag gaggaagtgg aggggacatc gctgttcccc agaaacccac tctatcctca     1020

ccctgttttg tgctcttccc ctcgcctgct agggctgcgg cttctgactt ctagaagact     1080

aaggctggtc tgtgtttgct tgtttgccca cctttggctg atacccagag aacctgggca     1140

cttgctgcct gatgcccacc cctgccagtc attcctccat tcacccagcg ggaggtggga     1200

tgtgagacag cccacattgg aaaatccaga aaaccgggaa cagggatttg cccttcacaa     1260

ttctactccc cagatcctct cccctggaca caggagaccc acagggcagg accctaagat     1320

ctggggaaag gaggtcctga gaaccttgag gtacccttag atccttttct acccactttc     1380

ctatggagga ttccaagtca ccacttctct caccggcttc taccagggtc caggactaag     1440

gcgtttttct ccatagcctc aacattttgg gaatcttccc ttaatcaccc ttgctcctcc     1500

tgggtgcctg gaagatggac tggcagagac ctctttgttg cgttttgtgc tttgatgcca     1560

ggaatgccgc ctagtttatg tccccggtgg ggcacacagc ggggggcgcc aggttttcct     1620

tgtcccccag ctgctctgcc cctttcccct tcttccctga ctccaggcct gaacccctcc     1680

cgtgctgtaa taaatctttg taaat                                           1705


<210> 1406
<211> 3338
<212> DNA
<213> Homo sapiens

<400> 1406
acttccggtg cttgccctgc ccatccccgt ggcgggggcg tggccatggc gggggcgctc       60

cggcgggggc gggccctggg ctcccgccct tcgggtccca cagtttccag ccgccgctct      120

cctcagtgcc cggtggccca ggagggcctg ggagcccgaa gccgtccccg agtcgctcct      180

aggtcactgg cgcgatgcgg gccgtcctct cggctgatgg gttggaagcc cagcgaggct      240

agaggccagt cccaaagttt ccaggcatca gggctgcagc ccaggagcct caaggcggcc      300

cggcgggcga ctggacggcc ggacaggtcc cgagcagccc ggcccaccat ggacccctct      360

gcccacaggt cccgagcagc cccgcccaac atggacccag acccccaggc gggcgtgcag      420

gtgggcatgc gggtggtgcg cggcgtggac tggaagtggg gccagcagga cggcggcgag      480

ggcggcgtgg gcacggtggt ggagcttggc cgccacggca gcccctcgac acccgaccgc      540

acagtggtcg tgcagtggga ccagggcacg cgcaccaact accgcgccgg ctaccagggc      600

gcgcacgacc tgctgctgta cgacaacgcc cagatcggcg tccggcaccc caacatcatc      660

tgtgactgct gcaagaagca cgggctgcgg gggatgcgct ggaagtgccg tgtgtgcctg      720

gactacgacc tctgcacgca gtgctacatg cacaacaagc atgagctcgc ccacgccttc      780

gaccgctacg agaccgctca ctcgcgccct gtcacactga gtccccgcca gggcctcccg      840

aggatcccac taaggggcat cttccaggga gcgaaggtgg tgcgaggccc cgactgggag      900

tggggctcac aggatggagg ggaagggaaa ccgggccgtg tggtggacat ccgtggctgg      960

gatgtggaga caggccggag tgtggccagc gtgacgtggg ctgatggtac caccaatgtg     1020

taccgtgtgg gccacaaggg caaggtggac ctcaagtgtg tgggcgaggc agcgggcggc     1080

ttctactaca aggaccacct cccaaggctc ggcaagccgg cggagctgca gcgcagggtg     1140

agtgctgaca gccagccctt ccagcacggg gacaaggtca agtgtctgct ggacactgat     1200

gtcctgcggg agatgcagga aggccacggc ggctggaacc ccaggatggc ggagtttatc     1260

ggacagacgg gcaccgtgca tcgtatcacg gaccgcgggg acgtgcgcgt gcagttcaac     1320

cacgagacgc gctggacctt ccaccccggg gcgctcacca agcaccactc cttctgggtg     1380

ggcgacgtgg tccgggtcat cggcgacctt gacacagtga agcggctgca ggctgggcat     1440

ggcgagtgga cggacgacat ggcccctgcc ctgggccgcg tcgggaaggt ggtgaaagtg     1500

tttggagacg ggaacctgcg tgtagcagtc gctggtcagc ggtggacctt cagcccctcc     1560

tgcctggtgg cctaccggcc cgaggaggat gccaacctgg acgtggccga gcgcgcccgg     1620

gagaacaaaa gctcactgag cgtggccctg gacaagcttc gggcccagaa gagtgaccca     1680

gagcacccgg gaaggctggt ggtggaggtg gcgctgggta acgcagcccg ggctctggac     1740

ctgctgcgga ggcgcccaga gcaggtggac accaagaacc aaggcaggac cgctctgcaa     1800

gtggctgcct acctgggcca ggtggagttg atacggctgc tgctacaagc cagggcgggc     1860

gtggacctgc cggacgacga gggcaacacg gcactgcact acgcggccct ggggaaccag     1920

cccgaggcca ccagggtgct cctgagtgct gggtgccggg cggacgccat caacagcacc     1980

cagagcacag cactgcacgt ggccgtgcag aggggcttcc tggaggtggt gcgggccctg     2040

tgtgagcgcg gctgtgacgt caacctgccc gacgcccact cggacacgcc cctgcactcc     2100

gccatctcgg cgggcactgg agccagcggc attgtcgagg tcctcacgga ggtgccaaac     2160

atcgatgtta ccgccaccaa cagccagggt ttcaccctgc tgcaccatgc ctccctcaag     2220

ggtcacgcgc tagctgtgag aaagattctg gctcgggcgc ggcagctggt ggacgccaag     2280

aaggaggacg gcttcacggc gctgcatctg gctgccctca acaaccaccg cgaggtggcc     2340

cagatcctca tccgggaggg ccgctgtgac gtgaacgtgc gcaaccggaa gctgcagtcc     2400

ccgctgcatc tcgccgtgca acaggcccac gtggggctgg tgccgctact ggtggacgct     2460

gggtgcagtg tcaacgccga ggacgaggag ggggacacag ccctgcacgt ggcgctgcag     2520

cgtcatcagc tgctgcccct ggtggctgat ggggccgggg gggacccagg gcccttgcag     2580

ctgctgtcca ggctacaggc ctcgggcctc cccggcagcg cggagctgac ggtgggcgcg     2640

gcggtcgcct gcttcctggc gctggagggc gccgacgtga gctacaccaa ccaccgcggt     2700

cggagcccgc tggacctggc cgccgagggt cgcgtgctca aggcccttca gggctgcgcc     2760

cagcgcttcc gggagcggca ggcgggcggg ggcgcggccc cgggccccag gcaaacgctc     2820

gggaccccca acaccgtgac gaacctgcac gtgggcgccg cgccggggcc cgaggccgct     2880

gagtgcctgg tgtgctccga gctggcgctg ctggtgctgt tctcgccgtg ccagcaccgc     2940

accgtgtgtg aggagtgcgc gcgcaggatg aagaagtgca tcaggtgcca ggtggtcgtc     3000

agcaagaaac tgcgcccaga cggctctgag gtggcgagcg ccgcccccgc ccccggcccg     3060

ccgcgccagc tggtggagga gctgcagagc cgctaccggc agatggagga acgcatcacc     3120

tgccccatct gcatcgacag ccacatccgc ctcgtgttcc agtgcggcca cggcgcatgc     3180

gccccctgcg gctccgcgct cagcgcctgc cccatctgcc gccagcccat ccgcgaccgc     3240

atccagatct tcgtgtgagc cgcgccgtcc gccgcgcccg agctgccttc gcgtgccccc     3300

gccctgtgtt ttataaaaag aaagattctc ggacgttg                             3338


<210> 1407
<211> 2191
<212> DNA
<213> Homo sapiens

<400> 1407
ggacgggggc ccggtgggcc cgcggaggaa agatactggg gagtgggagc cgcggggttc       60

agagcgatga ttcccccaca ggaggcatcc gctcgacggc gggagattga ggacaagctg      120

aagcaggagg aggagactct gtccttcatc cgagacagcc tggagaagag cgaccagctc      180

actaagaaca tggtgtctat cttatcatcc tttgagagcc gccttatgaa gctggagaac      240

tccatcatcc ctgtgcacaa gcagacggag aatctgcagc ggctgcagga gaatgttgag      300

aagacgctgt cctgcctgga ccatgtcatc agctactacc atgtggccag tgacactgag      360

aagatcatca gagagggccc cacaggtagg ctggaagagt acctgggaag catggccaag      420

attcagaagg cagtggagta tttccaggac aacagcccag acagcccgga actcaacaaa      480

gtgaaactgc tctttgagcg cgggaaggag gccctggagt ccgaatttcg cagcctgatg      540

acgcggcaca gtaaggtcgt ctcgcccgtg ctcatcttgg atctgatcag tggtgacgat      600

gatctggagg cccaggagga cgtgaccctg gagcacctgc ccgagagcgt gctccaggat      660

gtcattcgca tctcccgctg gctggtggaa tatggccgca accaagattt catgaacgtc      720

tactaccaga tacgctccag ccagctggac cgctccatca aaggactgaa ggagcatttc      780

cataagagca gttcttcctc tggggttccc tactcccctg ctatccccaa caagaggaaa      840

gacacaccta ccaagaagcc agtcaagcgg ccagggacga tccgtaaggc tcagaacctt      900

ctgaaacagt attcccagca tggtctagat gggaaaaagg ggggctctaa cctcattcct      960

ctggaaggga gagatgacat gctggacgtg gagaccgatg cctacatcca ctgcgtcagt     1020

gccttcgtca agctggcgca gagcgagtac cagctgctgg ccgacatcat ccccgagcac     1080

caccagaaga agaccttcga ctccctgata caggatgccc tggatgggct gatgcttgaa     1140

ggggagaaca tcgtgtctgc tgcccggaag gccattgtgc gacacgactt ctccacggtg     1200

ctcaccgtct tccccatcct gcgacacctc aagcagacca agcctgagtt tgaccaggtg     1260

ctccagggca cggctgccag cacaaagaac aagctgcctg gcctcatcac atccatggag     1320

accatcggtg ccaaagcgct ggaggacttc gcagacaaca tcaagaatga cccggacaag     1380

gagtacaaca tgccgaagga cggcaccgta cacgagctca ccagcaatgc catcctcttc     1440

ctgcagcagc ttttggactt ccaggagacg gcaggcgcca tgctggcctc ccaagagacc     1500

agctcttcgg ccaccagcta cagctctgag ttcagcaagc ggctgctaag cacctatatc     1560

tgtaaagtgc tgggcaacct gcagttgaac ttgctgagca agtccaaggt gtacgaggac     1620

ccagctctga gcgccatctt cctgcacaac aactacaatt acatcctcaa gtccctggag     1680

aagtctgaac tgatccagct ggtggcagtg acacagaaga ctgctgagcg ctcctaccgg     1740

gagcacattg agcagcagat ccagacctac cagcgcagct ggttaaaggt gactgattac     1800

atcgcagaga agaatctacc tgtgttccag ccgggagtca agctccggga caaggagcgg     1860

cagattatca aggagcgttt taagggcttc aatgatggcc tcgaagaact gtgcaaaatc     1920

cagaaggcct gggctattcc agacacagag cagagggaca ggattcgcca ggcccagaag     1980

accattgtca aggagaccta cggggccttt ctacagaagt ttggcagcgt gcccttcacc     2040

aagaacccgg agaagtacat caagtacggg gtggagcagg tgggcgacat gatcgatcgc     2100

cttttcgaca cctctgcctg agcctgctgc tagccctgcc tggttccacc agactggcgt     2160

gtcattggac agataaacca gtgttagctt g                                    2191


<210> 1408
<211> 3991
<212> DNA
<213> Homo sapiens

<400> 1408
gtcgcggcct tcgccgccgc caacggggct gtccctgtag ctcccgatgg agtttgaggt       60

cgtgaaacct ccgccgagct ctgccccggc gagacgaggc gcctccgtcg ccaagccgcg      120

ccgtcgcggg gctcccggga gcggccctta gcgaccccgc ccgggccccc tcagcttaca      180

aaacactaca cagcaaaata atgatctgct agactgctaa cccgagcatc cagcttccac      240

aatgcctgtg caggcagctc aatggacaga atttctgtcc tgtccaatct gctataatga      300

atttgatgag aatgtgcaca aacccatcag tttaggttgt tcacacactg tttgcaagac      360

ctgcttgaat aaacttcatc gaaaagcttg tccttttgac cagactgcca tcaacacaga      420

tattgatgta cttcctgtca acttcgcact tctccagtta gttggagccc aggtaccaga      480

tcatcagtca attaagttaa gtaatctagg tgagaataaa cactatgagg ttgcaaagaa      540

atgcgttgag gatttggcac tctacttaaa accactaagt ggaggtaaag gtgtagctag      600

cttgaaccag agtgcactga gccgtccaat gcaaaggaaa ctggtgacac ttgtaaactg      660

tcaactggtg gaggaagaag gtcgtgtaag agccatgcga gcagctcgtt cccttggaga      720

aagaactgta acagaactga tattacagca ccagaaccct cagcagttgt ctgccaatct      780

atgggccgct gtcagggctc gaggatgcca gtttttaggg ccagctatgc aagaagaggc      840

cttgaagctg gtgttactgg cattagaaga tggttctgcc ctctcaagga aagttctggt      900

actttttgtt gtgcagagac tagaaccaag atttcctcag gcatcaaaaa caagtattgg      960

tcatgttgtg caactactgt atcgagcttc ttgttttaag gttaccaaaa gagatgaaga     1020

ctcttcccta atgcagctga aggaggaatt tcggagttat gaagcattac gcagagaaca     1080

tgatgcccaa attgttcata ttgccatgga agcaggactc cgtatttcac ctgaacagtg     1140

gtcctctctt ttgtatggtg atttggctca taaatcacac atgcagtcta tcattgataa     1200

gctacagtct ccagagtcat ttgcaaagag tgtccaggaa ttgacaattg ttttgcaacg     1260

aacaggtgac ccagctaact taaatagact gaggcctcat ttagagcttc ttgcaaacat     1320

agaccctaat ccagacgctg tttcaccaac ttgggagcag ctggaaaatg caatggtagc     1380

tgttaaaaca gtagttcatg gccttgtgga cttcatacaa aattatagta gaaaaggcca     1440

tgagacccct cagcctcagc caaacagcaa atacaagact agcatgtgcc gagatttgcg     1500

acagcaaggg ggttgtccac gaggaacaaa ttgtacattt gcccattctc aggaagagct     1560

tgaaaagtat cgattaagga acaaaaagat caatgccact gtaagaacgt ttcctcttct     1620

aaataaagtt ggtgtaaaca acactgtcac aaccacagcc ggaaatgtca tttctgtcat     1680

aggaagtact gaaacaacag ggaaaattgt tccaagtaca aacggaattt caaatgcaga     1740

aaacagtgtt tcccagctaa tctcacgtag tactgacagt accttaagag ctctggagac     1800

cgtgaagaaa gtgggaaagg ttggcgctaa tggtcagaat gctgctgggc cctctgcaga     1860

ttctgtaact gaaaataaaa ttggttctcc acccaagact cctgtaagta atgtagcagc     1920

tacctcagct gggccctcta atgttggaac agagctgaat tctgtgcctc aaaaatccag     1980

cccatttcta actagagtac cagtatatcc tccgcattct gaaaacattc agtattttca     2040

agatccaagg actcagatac cctttgaagt cccacagtac ccacagacag gatactatcc     2100

accacctcca acggtaccag ctggtgtggc tccctgtgtt cctcgctttg tgaggtccaa     2160

taacgttcca gagtcctccc tcccacctgc ttccatgcca tatgccgatc attacagtac     2220

attttcccct cgagatcgaa tgaattcttc tccttaccag cctcctcctc cgcagccgta     2280

tggaccagtt cctccagtac cttctggaat gtatgctcct gtgtacgaca gcaggcgcat     2340

ctggcgccca cctatgtacc aacgagatga cattattaga agcaattctt tacctccaat     2400

ggatgtgatg cactcatctg tctatcagac atctttgcgg gaaagatata actcattaga     2460

tggatattat tcggtggctt gtcagccacc aagtgagcca aggacaactg tgcctttacc     2520

aagggaacct tgtggtcatt tgaagaccag ttgcgaggag cagataagaa gaaagccaga     2580

tcagtgggca cagtaccaca ctcagaaagc acctcttgtc tcttcaactc ttcctgtggc     2640

aacacagtca ccaacaccac cttctcctct gttcagtgta gactttcgtg cggatttctc     2700

agagagtgtg agtggtacaa aatttgaaga agatcatctt tcccattatt ctccctggtc     2760

ttgtggcacc ataggctcct gtataaatgc cattgattca gagcccaaag atgtcattgc     2820

taattcaaat gctgtgttaa tggacctgga cagtggtgat gttaagagaa gagtacattt     2880

atttgaaacc cagagaagga caaaagaaga agatccaata attcccttta gtgatggacc     2940

catcatctca aaatggggtg cgatttccag atcttcccgt acaggttacc ataccacaga     3000

tcctgtccag gccactgctt cccaaggaag tgcgactaag cccatcagtg tatcagatta     3060

tgtcccttat gtcaatgctg ttgattcaag gtggagttca tatggcaacg aggccacatc     3120

atcagcacac tatgttgaaa gggacagatt cattgttact gatttatctg gtcatagaaa     3180

gcattccagt actggggacc ttttgagcct tgaacttcag caggccaaga gcaactcatt     3240

acttcttcag agagaggcca atgctttggc catgcaacag aagtggaatt ccctggatga     3300

aggccgtcac cttaccttaa accttttaag caaggaaatt gaactaagaa atggagagtt     3360

acagagtgat tatacagaag atgcaacaga tactaaacct gatagggata tcgagttaga     3420

gctttcagca cttgatactg atgaacctga tggacaaagt gaaccaattg aagagatctt     3480

ggacatacag cttggtatca gttctcaaaa tgatcagttg ctaaatggaa tggcagtgga     3540

aaatgggcat ccagtacagc agcaccaaaa ggagccacca aagcagaaga aacagagttt     3600

aggtgaagac catgtgattc tggaggagca aaaaacaatt ctgccggtaa cttcttgctt     3660

tagccagcca ctcccagtgt ctattagcaa tgcaagttgc ctccccatca ccacatctgt     3720

cagtgctggc aacctcattc tgaaaactca tgttatgtct gaagataaaa acgacttttt     3780

aaaacctgtt gcaaatggga agatggttaa cagctgaaag gaggttcatc tttcaaattt     3840

gtgaccacac catggaagca tttacactag ctttttatat atataatata tattatataa     3900

tgtatatttt ttttaaaaaa aagatattac tgggggcatc catttcctgt ggactctttg     3960

atacttcaag ccctcttgca ttagcattat g                                    3991


<210> 1409
<211> 8695
<212> DNA
<213> Homo sapiens

<400> 1409
gctggcggag cccgggaggc ggagaaggct gtcgttgcct tggccgtcgc atccccgagg       60

gagtcgtgtc ggcgccaccc cggcccccga gcccgcagat tgcccaccga agctcgtgtg      120

tgcacccccg atcccgccag ccactcgccc ctggcctcgc gggccgtgtc tccggcatca      180

tgtgtggtat atttgcttac ttaaactacc atgttcctcg aacgagacga gaaatcctgg      240

agaccctaat caaaggcctt cagagactgg agtacagagg atatgattct gctggtgtgg      300

gatttgatgg aggcaatgat aaagattggg aagccaatgc ctgcaaaatc cagcttatta      360

agaagaaagg aaaagttaag gcactggatg aagaagttca caagcaacaa gatatggatt      420

tggatataga atttgatgta caccttggaa tagctcatac ccgttgggca acacatggag      480

aacccagtcc tgtcaatagc cacccccagc gctctgataa aaataatgaa tttatcgtta      540

ttcacaatgg aatcatcacc aactacaaag acttgaaaaa gtttttggaa agcaaaggct      600

atgacttcga atctgaaaca gacacagaga caattgccaa gctcgttaag tatatgtatg      660

acaatcggga aagtcaagat accagcttta ctaccttggt ggagagagtt atccaacaat      720

tggaaggtgc ttttgcactt gtgtttaaaa gtgttcattt tcccgggcaa gcagttggca      780

caaggcgagg tagccctctg ttgattggtg tacggagtga acataaactt tctactgatc      840

acattcctat actctacaga acagctagga ctcagattgg atcaaaattc acacggtggg      900

gatcacaggg agaaagaggc aaagacaaga aaggaagctg caatctctct cgtgtggaca      960

gcacaacctg ccttttcccg gtggaagaaa aagcagtgga gtattacttt gcttctgatg     1020

caagtgctgt catagaacac accaatcgcg tcatctttct ggaagatgat gatgttgcag     1080

cagtagtgga tggacgtctt tctatccatc gaattaaacg aactgcagga gatcaccccg     1140

gacgagctgt gcaaacactc cagatggaac tccagcagat catgaagggc aacttcagtt     1200

catttatgca gaaggaaata tttgagcagc cagagtctgt cgtgaacaca atgagaggaa     1260

gagtcaactt tgatgactat actgtgaatt tgggtggttt gaaggatcac ataaaggaga     1320

tccagagatg ccggcgtttg attcttattg cttgtggaac aagttaccat gctggtgtag     1380

caacacgtca agttcttgag gagctgactg agttgcctgt gatggtggaa ctagcaagtg     1440

acttcctgga cagaaacaca ccagtctttc gagatgatgt ttgctttttc cttagtcaat     1500

caggtgagac agcagatact ttgatgggtc ttcgttactg taaggagaga ggagctttaa     1560

ctgtggggat cacaaacaca gttggcagtt ccatatcacg ggagacagat tgtggagttc     1620

atattaatgc tggtcctgag attggtgtgg ccagtacaaa ggcttatacc agccagtttg     1680

tatcccttgt gatgtttgcc cttatgatgt gtgatgatcg gatctccatg caagaaagac     1740

gcaaagagat catgcttgga ttgaaacggc tgcctgattt gattaaggaa gtactgagca     1800

tggatgacga aattcagaaa ctagcaacag aactttatca tcagaagtca gttctgataa     1860

tgggacgagg ctatcattat gctacttgtc ttgaaggggc actgaaaatc aaagaaatta     1920

cttatatgca ctctgaaggc atccttgctg gtgaattgaa acatggccct ctggctttgg     1980

tggataaatt gatgcctgtg atcatgatca tcatgagaga tcacacttat gccaagtgtc     2040

agaatgctct tcagcaagtg gttgctcggc aggggcggcc tgtggtaatt tgtgataagg     2100

aggatactga gaccattaag aacacaaaaa gaacgatcaa ggtgccccac tcagtggact     2160

gcttgcaggg cattctcagc gtgatccctt tacagttgct ggctttccac cttgctgtgc     2220

tgagaggcta tgatgttgat ttcccacgga atcttgccaa atctgtgact gtagagtgag     2280

gaatatctat acaaaatgta cgaaactgta tgattaagca acacaagaca ccttttgtat     2340

ttaaaacctt gatttaaaat atcacccctt gaagcctttt tttagtaaat ccttatttat     2400

atatcagtta taattattcc actcaatatg tgatttttgt gaagttacct cttacatttt     2460

cccagtaatt tgtggaggac tttgaataat ggaatctata ttggaatctg tatcagaaag     2520

attctagcta ttattttctt taaagaatgc tgggtgttgc atttctggac cctccacttc     2580

aatctgagaa gacaatatgt ttctaaaaat tggtacttgt ttcaccatac ttcattcaga     2640

ccagtgaaag agtagtgcat ttaattggag tatctaaagc cagtggcagt gtatgctcat     2700

acttggacag ttagggaagg gtttgccaag ttttaagaga agatgtgatt tattttgaaa     2760

tttgtttctg ttttgttttt aaatcaaact gtaaaactta aaactgaaaa attttattgg     2820

taggatttat atctaagttt ggttagcctt agtttctcag acttgttgtc tattatctgt     2880

aggtggaaga aatttaggaa gcgaaatatt acagtagtgc attggtgggt ctcaatcctt     2940

aacatatttg cacaatttta tagcacaaac tttaaattca agctgctttg gacaactgac     3000

aatatgattt taaatttgaa gatgggatgt gtacatgttg ggtatcctac tactttgtgt     3060

tttcatctcc taaaagtggt ttttatttcc ttgtatctgt agtcttttat tttttaaatg     3120

actgctgaat gacatatttt atcttgttct ttaaaatcac aacacagagc tgctattaaa     3180

ttaatattga tatattcagt attctcttca actttgtcac gaggaagaat ttcctgtagt     3240

taattttaac tttccttcat tacattgttg cataaaacta gtcccttagt gccagtttgg     3300

aagttacttg caattgtttg gaagatttgc aggtcgctga cctcatcatt tcactctaag     3360

tatatgtggt aggctaagct cagaaaaagg tatgtatgct ttacactgat aggcaccaaa     3420

tttagtattg tatcctaagt atttttcctc ttctgtattt tctgtgctct acccctgaaa     3480

tatatttagg aataaagaag atataaataa agtgatattg gggtatgttc agcttgtaag     3540

tgtcagaaat ggaagttgac aatttggatt aaaatattta aagtagaatg ttattatttg     3600

atacccccaa aattgtgagt aataatttct taatggagct tttctggcca gatcttcagg     3660

gctataggag agtgtgtttg tttttggtga agtccttctt tttcaaaggt ttttactttt     3720

aaattgtgaa gataagctat ttagcacaat tatttaagta agctgttttt tcctttcttt     3780

tctttctttt cttgttttaa cttctgggtg aggttaagat tttctaatag ttattgttgt     3840

tgccagagaa gcatagaatt ctgcttgtgt cttagggtta gagaaagatt tgttatattt     3900

tgaggtaatt tggaaggact ttcatacatg gtgactagaa acctgatctt tttaagaata     3960

aaatagggtc actatttaca ttatatataa tatatggcta ttatagctat attaatctac     4020

tttaattgtt tctaagatta ttttgtgtaa gtcagctagc gtgtgtatag tgtcatttct     4080

tatgttttgt atattaacgt tttacaaaca caatttgtgt gggtttgtag catttcttat     4140

agtttaaagt atgattcagc attctaagtt aaaactaata tgtgaagtca gtcattagtc     4200

tgcataatct ctgtctccct ctgtgtgtgt ctttctataa agcacatgtg tacacacaca     4260

cacacaaata tactgaaagc tagggtaagt tctaaactga atatcaaaaa ccaaaatcaa     4320

gaacaaagaa gtgatatttt ccaaacaaac atggattctc tgccgggtgc agtggctcag     4380

cctgtaatac cagcctccac tttgggagtc tgaggtggga gtattgcttg agctcaagag     4440

ttggagaaca gcctgggcaa catggtgaga cctggtcttt acaaaaattt ttttggccgg     4500

acgcagtggc tcacacctgt aatcccagca ctttgggagg ccgaggcagg ttgatcatga     4560

ggtcaagaga tcgagaccat cctggccaac atggtgaaac cccgtcttta ctaaaaatac     4620

aaaaattagc tgggagtggt ggcgtgcgcc tgtagtccca actacttggg aggctgaggc     4680

aggagaatcg cttgaaccca ggaggcggag gttgcagtga ggcgagatca cgccactaca     4740

ctccagcctg gcgacagagc aagactctct caaaaaaaaa aaaaaaaaat ttttttttta     4800

aatgggctgg gcatggtggc ttgtgcctgt agtctcagca acttgggagg cttaagtagt     4860

aggatcgctt gagcctggga ggttgaggct gcagtgagct gtgattgtgc cactgtgctt     4920

cagcttgagt gacagagtga gaccctcctg actcaaaaca aaaaacatgg tttctcctct     4980

ctctcctgtc ttcttactct ctatcccatt tgatgtagtg atttttaaat gcttttgtaa     5040

gttaattctt aacacaaaag agacattgta atgaggcaca ccactaaagt gagcatgccc     5100

aattaaaacc agtgtaatat aggataagaa aatctgattt ttcaaaaaag atactctaca     5160

taaagaatcc ttcatataaa aagttctttc ttgtagtaca tttaaagttt taattcactc     5220

atgtataact gagagttcct ttgagccctt tttaggcagg gaggcatgtc tgtcatctag     5280

cgtgtggccc agtaagtgat tattacattg gaatcagttt ttcagtcttt taaaataaat     5340

tctgtgccat aagaataaaa gataaagaga aaaattaatg ttaactattt ttagcttatt     5400

ataactatgt caacaagtgt ttattaatac ctattatggg aaagtcactg tggttggcat     5460

tgaaaattac atcatcttta aagcagtatt tgtccccaga tggactcatc actagcaaag     5520

actaggttca ttggaaggca tagggtgaga gaatgggaag atgaagtgga ggcgggttgt     5580

taaagtgctg tcagtgagtg attttgtcta cttgaataat ggtccatgtt tgggggcata     5640

ttgtgtttca taagaagtga aaggtatttg caaagtaagc tacaaatgac ccataaatct     5700

gttaacaaca gtccttaata tgcaaagatg aaaaacaagc attactgcta cccaaaggga     5760

actggtgctt ggtgatgtgc agatggggct gttggttaag agagctatta caggttttct     5820

ctcttaggtt tcataggagg tagttactga gatgagattg ttttatcttt ttgaatacag     5880

atctcttgtc ttgagttagt tctgaggatg ggagtaataa aggagttttt tgtttttttg     5940

tttgtttgtt tgttttggct ccttagtaat actcctctga catttatttc tattattctt     6000

caaagaaagg aaaccaactg aaatgtttgc tttaacaaac attttaataa gttctctggg     6060

tttttttttc cccttttaaa aaaattagca tataccatag caataaaaga actaatgtta     6120

actattgtat gctacaactt aagtgatttt tctaaagaag cacaatgtca ttgaaagtat     6180

tattgaaaag gatcatagtc acattgaatt tgtgaaggcc aaagaaattg aagggagtga     6240

tattttcatt ttatgatatt cacatattta gtaaattttg tgtacaagaa taccaggcag     6300

agtgttttac ccatggaaac aggtttcaga ttactttatt tttactgtta gagtctcaag     6360

tttagaaatg ctaacactta aatcagtttt tttctcacta tacttgaaga ttgttaatat     6420

tttgatatct tcctagcttg atgaatttaa acatatcttc agatctgtga cagtgacagc     6480

caataggact gataatatta gcttcaaacc aataatatcc agggttaaaa taaaaatcat     6540

agtgaaagta cgattgtaaa attatgctat attaactttt aagtctgtaa taacttgaca     6600

tcaaaatgtt atgtaattac cataaataat ggctagcgag aacatctttg gaaattctca     6660

aattaccttt cttactacac tgtttgcaga atgaatgtag aaatgatcct gttagctttc     6720

tgaatgttct gtggttgaat gtgtttttgc ttaaataaag cttttggtat ttgtttaaat     6780

tacacttctt gagaagtgga aattttagga tcatctttgc tttgtttcag ttttgtgatt     6840

tttgaaatga atgtttagtt tactgagcca gttggtcatt tcttcctcat gtcgttaagt     6900

ccagtgagta agcctgaact gtgaataaat taccaaaaac ttgcttagaa tttcattttg     6960

aagcaatttg ctaatatttg aagtgtatac acatttgtag ttatgttaga aattgtattg     7020

tactaagaat gtaatcaatg tctactttag ttgtaaacat ttctgatgtc aaaactttat     7080

tcattactgt tgattttaag aataagaaat cactgcctaa atattaccaa aagccactgt     7140

ctctacccga acttcccagt ttgggaaaga atcgttagat aaaacaaagg ctctgccctt     7200

tctgatacca aactccacag atactttctc acatctttta aaacattttg caataacata     7260

ttgtttatag gaagtttacg gggtatgcaa tgattaaaac ttttaagtga attgatagtt     7320

gcaaaagaaa ggataatatt taaggtcagt gagtagcaag acaatctaaa gtttctgtaa     7380

tatctggctc tctgttaatt atagagcaaa gtttccctta cagaatcctt ttatgaacag     7440

caagctagag tctatcccta gtggttatag cacctgctgc gtttttcagg agacagttag     7500

gccagggtga tttgaatgga tagatgtgct gttttgcctg cttgtagaat tcagcccagt     7560

ctttggtctc tctctctctc tccctcctcc acctctccct ctctcttctt ctgcaccaga     7620

gcctaaggct gcgccaccaa gatgcgtcat tttttccaga ggcttctttt tttttttttt     7680

gagatggagt tttgctctgt tgcccaggct ggcatgcagt gctgcaatct tggctgactg     7740

caacttccac ctcccgtgtt cacacgagtc ttttgcctca gcctctggat tagctgggat     7800

tacaggcacg tgccaccatg cctagctaat ttttgtgttt ttagtagaga cggggtttca     7860

ccatgttggc caggctagtc tcaaactcct gaccttaagt gatctgcccg ccttggcctc     7920

ccaaagtgct gggattacag gcatgagtca ccgtgtcctg cccagacata tcaaatttga     7980

caggtattgt ataccctttg gatctttagg aattaatttt tgcctctgtc actcagcttt     8040

gtatattttg aaatggagat aagtataggg aggtcttgga aggaaaattg ccagaattcc     8100

caaaccatgt aacactcatt gagaattcca gatccattat atctaaaggg caagtgaagg     8160

aaacagtatt gtgaactggg tataactcct tggttcttaa ctagtacatt cttaatctgt     8220

gagacccaaa ggttgataaa caataattta agattgtaca gtactctaaa cgtctgcaaa     8280

ggtctagatg ttatcagtat cactagtttt tatttctgcc agtagctccc ttttaggtta     8340

cattgttgtc ctctttccag tgtcgcatct gtcattggtt tttcactatg gcaagttcat     8400

taaaaagctt gctccattgt tatcttcaag taatgcccat aaggagatgg aagatatctg     8460

agacaattaa ggctttagct tctaggcaag agaaataacg ttgcattaaa tttcaagttt     8520

ctttctgcta gacttgaatg tgtctagcca ctctaattta tgggggcttt tggttttttc     8580

ctattgtact ttgtatgtag aattgttttg aaatatcaag catatttact ttgaatttga     8640

actctttctt aattttgtat ttatcctttg aataaaatgt aaatccaata tttat          8695


<210> 1410
<211> 3700
<212> DNA
<213> Homo sapiens

<400> 1410
ccattgaatc ccagtcctaa cagaagtact gcgaatcttg tggcctcatt ctgaacaaaa       60

gggattagag aagaaaaatc tcttgatata aggcttgaaa gcaagggcag gcaatcttgg      120

ttgtgaatat tttctgattt ttccagaaat caagcagaag attgagctgc tgatgtcagt      180

taactctgag aagtcgtcct cttcagaaag gccggagcct caacagaaag ctcctttagt      240

tcctcctcct ccaccgccac caccaccacc accgccacct ttgccagacc ccacaccccc      300

ggagccagag gaggagatcc tgggatcaga tgatgaggag caagaggacc ctgcggacta      360

ctgcaaaggt ggatatcatc cagtgaaaat tggagacctc ttcaatggcc ggtatcatgt      420

tattagaaag cttggatggg ggcacttctc tactgtctgg ctgtgctggg atatgcaggg      480

gaaaagattt gttgcaatga aagttgtaaa aagtgcccag cattatacgg agacagcctt      540

ggatgaaata aaattgctca aatgtgttcg agaaagtgat cccagtgacc caaacaaaga      600

catggtggtc cagctcattg acgacttcaa gatttcaggc atgaatggga tacatgtctg      660

catggtcttc gaagtacttg gccaccatct cctcaagtgg atcatcaaat ccaactatca      720

aggcctccca gtacgttgtg tgaagagtat cattcgacag gtccttcaag ggttagatta      780

cttacacagt aagtgcaaga tcattcatac tgacataaag ccggaaaata tcttgatgtg      840

tgtggatgat gcatatgtga gaagaatggc agctgaggcc actgagtggc agaaagcagg      900

tgctcctcct ccttcagggt ctgcagtgag tacggctcca cagcagaaac ctataggaaa      960

aatatctaaa aacaaaaaga aaaaactgaa aaagaaacag aagaggcagg ctgagttatt     1020

ggagaagcgc ctgcaggaga tagaagaatt ggagcgagaa gctgaaagga aaataataga     1080

agaaaacatc acctcagctg caccttccaa tgaccaggat ggcgaatact gcccagaggt     1140

gaaactaaaa acaacaggat tagaggaggc ggctgaggca gagactgcaa aggacaatgg     1200

tgaagctgag gaccaggaag agaaagaaga tgctgagaaa gaaaacattg aaaaagatga     1260

agatgatgta gatcaggaac ttgcgaacat agaccctacg tggatagaat cacctaaaac     1320

caatggccat attgagaatg gcccattctc actggagcag caactggacg atgaagatga     1380

tgatgaagaa gactgcccaa atcctgagga atataatctt gatgagccaa atgcagaaag     1440

tgattacaca tatagcagct cctatgaaca attcaatggt gaattgccaa atggacgaca     1500

taaaattccc gagtcacagt tcccagagtt ttccacctcg ttgttctctg gatccttaga     1560

acctgtggcc tgcggctctg tgctttctga gggatcacca cttactgagc aagaggagag     1620

cagtccatcc catgacagaa gcagaacggt ttcagcctcc agtactgggg atttgccaaa     1680

agcaaaaacc cgggcagctg acttgttggt gaatcccctg gatccgcgga atgcagataa     1740

aattagagta aaaattgctg acctgggaaa tgcttgttgg gtgcataaac acttcacgga     1800

agacatccag acgcgtcagt accgctccat agaggtttta ataggagcgg ggtacagcac     1860

ccctgcggac atctggagca cggcgtgtat ggcatttgag ctggcaacgg gagattattt     1920

gtttgaacca cattctgggg aagactattc cagagacgaa gaccacatag cccacatcat     1980

agagctgcta ggcagtattc caaggcactt tgctctatct ggaaaatatt ctcgggaatt     2040

cttcaatcgc agaggagaac tgcgacacat caccaagctg aagccctgga gcctctttga     2100

tgtacttgtg gaaaagtatg gctggcccca tgaagatgct gcacagttta cagatttcct     2160

gatcccgatg ttagaaatgg ttccagaaaa acgagcctca gctggcgaat gccttcggca     2220

tccttggttg aattcttagc aaattctacc aatattgcat tctgagctag caaatgttcc     2280

cagtacattg gacctaaacg gtgactctca ttctttaaca ggattacaag tgagctggct     2340

tcatcctcag acctttattt tgctttgagg tactgttgtt tgacattttg ctttttgtgc     2400

actgtgatcc tggggaaggg tagtcttttg tcttcagcta agtagtttac tgaccatttt     2460

cttctggaaa caataacatg tctctaagca ttgtttcttg tgttgtgtga cattcaaatg     2520

tcattttttt gaatgaaaaa tactttcccc tttgtgtttt ggcaggtttt gtaactattt     2580

atgaagaaat attttagctg agtactatat aatttacaat cttaagaaat tatcaagttg     2640

gaaccaagaa atagcaagga aatgtacaat tttatcttct ggcaaaggga catcattcct     2700

gtattatagt gtatgtaaat gcaccctgta aatgttactt tccattaaat atgggagggg     2760

gactcaaatt tcagaaaagc taccaagtct tgagtgcttt gtagcctatg ttgcatgtag     2820

cggactttaa ctgctccaag gagttgtgca aacttttcat tccataacag tcttttcaca     2880

ttggatttta aacaaagtgg ctctgggtta taagatgtca ttctctatat ggcactttaa     2940

aggaagaaaa gatatgtttc tcattctaaa atatgcatta taatttagca gtcccatttg     3000

tgattttgca tatttttaaa agtactttta aagaagagca atttcccttt aaaaatgtga     3060

tggctcagta ccatgtcatg ttgcctcctc tgggcgctgt aagttaagct ctacatagat     3120

taaattggag aaacgtgtta attgtgtgga atgaaaaaat acatatattt ttggaaaagc     3180

atgatcatgc ttgtctagaa cacaaggtat ggtatataca atttgcagtg cagtgggcag     3240

aatacttctc acagctcaaa gataacagtg atcacattca ttccataggt agctttacgt     3300

gtggctacaa caaattttac tagctttttc attgtctttc catgaaacga agttgagaaa     3360

atgattttcc ctttgcaggt tgcacacagt tttgtttatg catttcctta aaattaattg     3420

tagactccag gatacaaacc atagtaggca atacaatttt agaatgtaat atatagaggt     3480

atatttagcc tcttttagaa gtcagtggat tgaatgtctt tttattttaa attttacatt     3540

cattaaggtg cctcgttttt gactttgtcc attaacattt atccatatgc ctttgcaata     3600

actagattgt gaaaagctaa caagtgttgt aacaataatc cattgtttga ggtgcttgca     3660

gttgtcttaa aaattaaagt gttttggttt ttttttttcc                           3700


<210> 1411
<211> 2301
<212> DNA
<213> Homo sapiens

<400> 1411
ggcggccgag cggcgggcga cgggggcggg cgacgggggc gggcgacgcg ggccgcggca       60

cgggcggagc cggggccatg gagccgccgc tgccgggcta ggcaggtcgt gccccgccgg      120

gccggcggcg atgtcgggct accagcgccg cccgggcgcc accccgctgt cccgagcccg      180

gagcctcgcc attcccgacg ctccagcgtt ctatgagcgc cggtcttgtc tcccccagct      240

aaattgtgag cgcccccatg gcagggacct ggactccccc ttcttcggca ttcggccggc      300

ctttatgtgc tatgtgccca gcccggtgct ggcttccgtg ggagacacag attttggcta      360

tggaaagggg aaatgttcta agcagagccc gtcaggagcc cacgggacac attttggaga      420

tgacagattt gaagatctgg aagaggcaaa tccattctct tttagagagt ttctgaagac      480

caagaacctc ggcctctcga aagaggatcc ggccagcaga atttatgcaa aggaagcctc      540

gaggcattcc ctgggacttg accacaactc cccaccctcc caaaccggcg ggtatggcct      600

ggagtatcag cagccatttt tcgaggatcc gacaggggct ggtgacctcc tggatgagga      660

ggaggatgag gacaccggat ggagtggggc ctacctgccg tccgccatcg agcagactca      720

ccccgagagg gtccctgccg gcacgtcgcc ctgcagcaca tacctttcct ttttctccac      780

cccgtcggag ctggcagggc ctgagtctct gccctcgtgg gcgttgagtg acactgattc      840

tcgcgtgtct ccggcctctc cggcagggag tcctagcgca gactttgcgg ttcatggaga      900

gtctctggga gacaggcacc tgcggacgct gcagataagt tacgacgcac tgaaagatga      960

aaattctaag ctgagaagaa agctgaatga ggttcagagc ttctctgaag ctcaaacaga     1020

aatggtgagg acgcttgagc ggaagttaga agcaaaaatg atcaaggagg aaagcgacta     1080

ccacgacctg gagtcggtgg ttcagcaggt ggagcagaac ctggagctga tgaccaaacg     1140

ggctgtaaag gcagaaaacc acgtcgtgaa actaaaacag gaaatcagtt tgctccaggc     1200

gcaggtctcc aacttccagc gagagaatga agccctgcgg tgcggccagg gtgccagcct     1260

gaccgtggtg aagcagaacg ccgacgtggc cctgcagaac ctccgggtgg tcatgaacag     1320

tgcacaggct tccatcaagc aactggtttc cggagctgag acactgaatc ttgttgccga     1380

aatccttaaa tctatagaca gaatttctga agttaaagac gaggaggaag actcttgagg     1440

acccctgggt gttctcagca tgaagctccg tgtataccct gaggtcacca ccgctcgatc     1500

taaatgtgca gttgtgtcct taaatatgca gtcttcaccc agagtaaagt gttgatcgca     1560

agagtccagt gtcgtgccct cagccagttc ttggccacca caatgggagc agccctggcc     1620

gagttgtctc tgtggtttct atgcagccct tcttggcgaa attcctgcga tcttatagat     1680

tctaatgagc tcttggaaga cattgtcata aaagccagtg attttaagaa aaagagtggt     1740

tctggaatca atgttttcca gtcccatccc agaacatcag ttgtaagata agtacaattg     1800

gttgtccttg atttcataag tagaacaaac actaaatgtg cctctgagat ggccaccccg     1860

ggcagggacc tgtgccttcc gccgatgctc agggctccct ctggctcccg ggtcactctt     1920

gtggccccag tgggtggtcc ctgcagtcat ggcctgagtg cgcaggggcc accgcgtggc     1980

tgctgctgtc ctcctccggg acccacgggg accaaggtca cacgttccgt gctgtgaagc     2040

tgtccagatg tgcctctttg gctgggggtt ctggtggacg tttcaagtgg cattttgtac     2100

aatgcaggtt agaattcagg aatttcaagt atgtgcccgg gtctgtcagg tcccagttgc     2160

ctttctgacg gcccccctca gagggacggc gatgagcact aaatgctttt ttgactattt     2220

tcctatagat tttttttaaa actttttttt cctcctgttc caattgatag ctttcttatt     2280

taataaattc tgtagttcac c                                               2301


<210> 1412
<211> 1130
<212> DNA
<213> Homo sapiens

<400> 1412
gtgcgcactg gcgtgcgaga ctcggcgggc gctgttgagg gagtcgggcc gcgactgtgg       60

tcgtttttat accttcccgc gcggacgccg gcgctgccaa cggaagggcg ggtagggcgg      120

tgcgtgatta ggttggcgaa ggctctgctg ccatgaaggt gaagattaag tgctggaacg      180

gcgtggccac ttggctctgg gtggccaacg atgagaactg tggcatctgc aggatggcat      240

ttaacggatg ctgccctgac tgtcctctcc atggagaaag catttctagg tgtttgggct      300

ggtgcccgca gcctgtgcct gtcctgggag gcagggccca tccacaggtg cccatcaaca      360

cagcttcccc aacgcctggg cagcacaccg gatccctgat gtctagggaa gagtcttcta      420

ggtccccaga ccccacccct cctgcccttg atcaagagac cagttcacta ctcagatgca      480

cgtctccttg gtgccttgac cattcatgtg acctttttgg catcacagat caagtgtctg      540

cagatgggcc cagggcctgt aggcaaggtg cccggcgacg actgcccgct ggtgtggggc      600

cagtgctccc actgcttcca catgcattgc atcctcaagt ggctgcacgc acagcaggtg      660

cagcagcact gccccatgtg ccgccaggaa tggaagttca aggagtgagg cccgacctgg      720

ctctcgctgg aggggcatcc tgagactcct tcctcatgct ggcgccgatg gctgctgggg      780

acagcgcccc tgagctgcaa caaggtggaa acaagggctg gagctgcgtt tgttttgcca      840

tcactatgtt gacactttta tccaataagt gaaaactcat taaactactc aaatcttgct      900

ggaggcctct gggtgcctgt gttctcggca tatagatgtg gtctcggtgt gttttgatat      960

gaaaactctc atgaataaac atctccgtga aacgccaagg ccctcgtcaa accctgagtc     1020

atgactggga ggagaaggag caggatcaga cggtagagcc tggggcatgc tcttcaggca     1080

tgctcttgcc tgctggattg ccggcggcgg ccctgggacc ctccctcagg                1130


<210> 1413
<211> 9543
<212> DNA
<213> Homo sapiens

<400> 1413
gtttccggtg ttgtgactga aacccgtcaa tatggcggcg atcggccgcg gccgctctct       60

gaagaacctc cgagtacgag ggcggaatga cagcggcgag gagaacgtcc cgctggatct      120

gacccgagaa ccttctgata acttaagaga gattctccaa aatgtggcca gattgcaggg      180

agtatcaaat atgagaaagc taggccatct gaataacttt actaagcttc tttgtgatat      240

tggccacagt gaagaaaaac tgggctttca ctatgaggat atcataattt gtttgcggtt      300

agctttatta aatgaagcaa aagaagtgcg agcagcaggg ctacgagcgc ttcgatatct      360

catccaagac tccagtattc tccagaaggt gctaaaattg aaagtggact atttaatagc      420

taggtgcatt gacatacaac agagcaacga ggtagagagg acacaagcac ttcgattagt      480

cagaaagatg attactgtga atgcttcctt gtttcctagt tctgtgacca actcattaat      540

tgcagttgga aatgatggac ttcaagaaag agacagaatg gtccgagcat gcattgccat      600

tatctgtgaa ctagcacttc agaatccaga ggtggtggcc cttcgaggtg gactaaacac      660

catcttgaaa aatgtgatcg attgccaatt aagtcgaata aatgaggccc taattactac      720

aattttgcac cttcttaatc atccaaagac tcgacagtat gtgcgagctg atgtagaatt      780

agagagaatt ttagcaccct atactgattt tcactacaga catagtccag atacagctga      840

aggacagctc aaagaagaca gagaagcacg atttctagcc agtaaaatgg gaatcatagc      900

aacattccga tcatgggcag gtattattaa tttatgtaaa cctggaaatt ctgggatcca      960

gtctctaata ggagtacttt gcataccaaa tatggaaata aggcgaggtc tacttgaagt     1020

gctttatgat atatttcgtc ttcctctacc tgttgtgact gaggagttca tagaagcact     1080

actcagtgta gatccaggga ggttccaaga cagttggagg ctttcagatg gctttgtggc     1140

agctgaggca aaaactattc ttcctcatcg tgccagatcc aggccagacc tcatggataa     1200

ttatttggca ctgatactct ctgcatttat tcgtaatgga cttttagagg gtctagttga     1260

agtgataaca aacagtgatg atcatatctc agttagagct accatccttt taggagagct     1320

tttacatatg gcaaacacaa ttcttcctca ttcacatagc catcatttac actgcttgcc     1380

aaccctaatg aatatggctg catcctttga tatccccaag gaaaagagac tgcgagccag     1440

tgcagccttg aactgtttaa aacgcttcca tgaaatgaag aaacgaggac ctaagcctta     1500

tagtcttcat ttagaccaca ttattcagaa agcaattgca acacaccaga aacgggatca     1560

gtatctccga gttcagaaag atatatttat ccttaaggat acagaggaag ctcttttaat     1620

taaccttaga gatagccaag tccttcaaca taaagagaat cttgaatgga attggaatct     1680

tatagggacc attcttaagt ggccaaatgt aaatctaaga aactataaag atgaacagtt     1740

acacaggttt gtacgaagac tactttattt ttacaagccc agcagtaaat tatatgccaa     1800

cctggatctg gattttgcca aggccaaaca gctcacggtt gtaggttgcc agtttacaga     1860

atttcttctt gaatctgaag aggatgggca aggctactta gaagatctag taaaggatat     1920

tgttcagtgg ctcaatgctt catctggaat gaaacccgaa agaagtcttc aaaataatgg     1980

tttattgacc acccttagtc aacactactt tttatttatt ggaacacttt cttgccaccc     2040

tcatggagtt aaaatgctgg aaaaatgcag tgtatttcag tgtctcctta atctttgctc     2100

cttgaaaaac caagatcact tgctaaaact tactgtttct agcttggact atagcagaga     2160

tggattggct agagtcatcc tttccaaaat tttaactgca gctactgatg cctgcagact     2220

ctatgcaaca aaacatttaa gggtattatt gagagctaat gttgaattct ttaataattg     2280

gggaattgag ttgttagtga cccagctaca tgataaaaac aaaacgattt cctctgaagc     2340

tcttgatatc ctcgatgaag catgtgaaga caaggccaat cttcatgctc tcattcagat     2400

gaaaccagcg ttatcccacc ttggagacaa gggtttgctt ctcctgctga gatttctctc     2460

cattccaaaa ggattttcct atctgaatga aagaggttat gtagcaaaac aattggaaaa     2520

gtggcacagg gaatacaact ccaaatatgt tgacttgatt gaggaacaac tcaatgaagc     2580

acttactact taccggaagc ctgttgatgg tgataactat gttcgtcgga gtaaccaaag     2640

attacagcgt cctcacgtct acctgcctat acacctttat ggacaactag tacaccataa     2700

aacaggctgc catttgttgg aagtacagaa tattattaca gaactctgtc gtaatgttcg     2760

tacaccagat ttggataagt gggaagaaat taaaaaactg aaagcatctc tttgggcctt     2820

gggaaatatc ggctcatcaa attggggtct caatttgcta caggaagaaa acgtgattcc     2880

agatatacta aaacttgcaa aacagtgtga agttctttcc atcagaggga cctgtgtata     2940

tgtacttggg ctcatagcta aaaccaaaca aggctgtgat attctaaaat gtcacaactg     3000

ggatgctgtg aggcatagtc gcaaacatct gtggccagtg gttccagatg atgtggaaca     3060

actctgtaat gaactttcat ctatcccaag cactctaagt ttgaactcgg agtcaaccag     3120

ctctagacat aatagtgaaa gtgaatctgt gccatcgagt atgttcatat tggaggatga     3180

ccggtttggc agcagctcta ctagcacatt tttccttgat atcaatgaag atacagagcc     3240

aacattttat gaccgatctg gacccataaa ggataaaaat tcattccctt tctttgcttc     3300

tagtaaactt gtgaagaatc gtatcttaaa ttcgcttact ttgcctaaca aaaaacatcg     3360

tagtagcagt gatccaaaag gagggaaatt atcatctgaa agtaagacaa gcaacaggcg     3420

aatcagaaca cttacggagc ccagtgttga ttttaatcat agtgatgatt ttacacccat     3480

atccactgta cagaaaacat tacaattaga gacttcattt atggggaata agcacattga     3540

agacactggt agtacaccaa gcattggaga aaatgactta aaattcacca agaattttgg     3600

tacagagaat cacagagaaa atacaagccg agagaggtta gtagtagaaa gttcaacgag     3660

ctcacatatg aagatacgta gccaaagttt caatacagac actacaacaa gtggcataag     3720

ttcaatgagc tcaagtcctt cacgagagac agtaggtgta gatgctacaa ctatggacac     3780

agactgtgga agcatgagta ctgtggtaag tactaaaact attaagacaa gccactattt     3840

gacgccacag tctaaccatc tgtctctctc caaatcaaat tcggtgtccc tggtgcctcc     3900

aggttcttct catacgcttc ctagaagagc acagtccctt aaagcaccct ctattgctac     3960

aattaaaagt ctagcagatt gtaactttag ttacacaagt tctagagatg cttttggcta     4020

tgctacactg aaaagactac agcaacaaag aatgcatcca tccttatctc actctgaagc     4080

tttggcatct ccagcaaaag atgtgctatt tactgatacc atcaccatga aggccaacag     4140

ttttgagtcc agattaacac caagcaggtt catgaaagcc ttaagttatg catcattaga     4200

taaagaagat ttattgagtc ctattaatca aaataccctg caacgatctt cctcagtgcg     4260

gtccatggtg tccagtgcca catatggggg ttcagatgat tacattggtc ttgctctccc     4320

ggtggatata aatgatatat tccaggtaaa ggatattccc tattttcaga caaaaaacat     4380

accaccacat gatgatcgag gtgcaagagc atttgcccat gatgcaggag gtcttccatc     4440

tggaactgga ggtcttgtaa aaaattcttt tcacttgcta cgacagcaga tgagtcttac     4500

ggaaataatg aattcaatcc attcagatgc ctctctgttt ttagaaagta cagaagacac     4560

tggactacag gaacatacag atgataactg cctttattgt gtctgtattg aaattctggg     4620

tttccagccc agcaaccaac tgagtgcaat atgtagtcat tcagactttc aagatattcc     4680

atattctgat tggtgtgagc agactatcca taatccttta gaagtggttc cctctaagtt     4740

ttcggggatt tctggatgca gtgatggggt gtctcaagaa ggctcagcta gcagcaccaa     4800

aagcacagaa ttgttactag gtgttaaaac aattccagat gatacaccaa tgtgccgtat     4860

actccttcgc aaagaagttc taagattagt cattaatttg agtagttcag tttcaactaa     4920

atgtcatgag actgggcttt taacaattaa ggagaagtat cctcaaacat ttgatgacat     4980

atgcctttac tctgaggttt cccatttgct gtcacactgc acattcagac ttccgtgtcg     5040

gaggttcata caagaattat ttcaagatgt acagtttcta caaatgcatg aagaagcaga     5100

ggctgtgttg gcaacaccac caaagcaacc tatagttgat acatctgctg aatcctgacc     5160

tcatatttat gatggatata gatacatact atatatattc atatttgtgg atttcctaaa     5220

agcctcagaa aatacgactg actaggcagc aaagacagga gtatcttctg tacactgttc     5280

cgcagttact ggtacatgaa cagttggaac tgctgacttt cctaaccaaa acaacttcct     5340

tctctccttt gttgagcctt ttgaggggtt catgattcat taccacagtt ttaagagttt     5400

cagttaccat tgtatgcaag agccaagcac tgaataccta cataggtttt ctattttctt     5460

tcattttaaa agcataatga cagtggaaca ataatgggat atgcagaagc acccttcaca     5520

agttatttct gaatgatttt tagggtaaat aatacagatg ccttgtttgt taactaactt     5580

gtggaaagca ggaatcagtg tctctaaggc tgcatcctat taccacaatg gggtgtgcta     5640

taactgctgg tattagagag ggaactttgg ccctttcacg tttttcttaa tgtttgtaac     5700

actacttcag aggtttataa cctcaaagca gaagaagagc ctcaacaacc cgggacttat     5760

aagttatttt tatgttacta gacttgcata aagattcttg ttttccaact cttcattttg     5820

ttgcaatgtg ttattacagg atatatgaac caattaaggt ttttcactac agttcttgaa     5880

taaaatttaa aaatcatttt ttattttaat taaaaatatt tcccatttat agaatgcata     5940

tatttgcaat ggacttccac tttcatcaac tttccatctc atcgctttaa acaggaactt     6000

gaacaagcac tgttagttta gacctaaagg ataggaaagc attaaataat actttggatc     6060

tcctgaggaa aagataagtt tgcttgcaat ttacacattc catggggaaa gaagagccat     6120

atttccttaa aaaaaacatt aataaagctt gttattgaga aaaattgtag tgaaaagcct     6180

taagtaccaa attttaaagc agcagtaact taatttttat atcagtgttt ttgttttgca     6240

caaactaaat gcagtggtag gtgggtttat gagtatatta attgccttta tccatttgtg     6300

aagttaagtt gatgagggca aggtttttgt ttgtttaatt tgtatatgtc taaaggtatt     6360

tggaactttt tacaggaatt aaacatatat gcaaatttgt atataaaaat agcatggcca     6420

tcatttgaat gcttgtaaat gaaaggatta tcttttttga gatctatata taaatagaaa     6480

tagaaaatcc agctggactg attaggattc ttttttaatt catttgtgta taacattttt     6540

attacaatta cacatcagtt ttgacacagt catagcaaca ttaatatttt cccatgatgc     6600

agatcctttt tgtaatgggc ttgttctttg agatctctgt aaagaaccct gtgaactaga     6660

aaacataact cacagagata cttttttaaa aaatttattt actggaactg aaagttccag     6720

ttgggatgaa gcatttcatc tcacttcata acacctcttt gactgcactt cagtgaattg     6780

ttcttatgtg cactgtgtag caacttacat tataacaaag cagataaggg ctgtaagctg     6840

ctgcttatgt tgaaaagtgg ttcttcagat tttctctcat aaaatccagt tgaagataaa     6900

taattttttt atactttatc actgaaccca agtgtttatt taaatgtcaa cagtacttct     6960

aagaacgttg cctgtcatcg tggtctttgg tcttggataa ctaaactgcc tttccagaga     7020

accaaatgtc agagttacta gaccaaatag tggttaaaac ctccaaagga agtaatgtaa     7080

tcttattcat aatgggatta acatatttta gacattcatt ttaaacacta cctcagttaa     7140

tatagagtat aaaaatctgt ggtttaatcc ctcaaaagtt aacagtaatt ttttttttgt     7200

cttacacaca cacacacccc ctcccccacc atcactatcc ctgtaccctc accttggtca     7260

tctatcctga aataaggctt agttagtatt ggcctgaatg ttttgtgttt ttttttttgt     7320

tttttttttt tactgttact ttgaaaaata tgtatgtata ccttatcata tctgcctata     7380

tcacttactt tggggagata ctcagagctt tgtggttatc agtatactaa aaaaaaaaaa     7440

aagtctacgc ttaaatttat agtgctattt ggtttctcca tgatttcact gacaggtcta     7500

atacattttc tttgagtact tgtttgtaaa aagtagactt tatggtgaaa aatacatgca     7560

gtgccaagtg attaacttaa gtgtttaaaa atattaaatt atagcagaag aggttaggaa     7620

tgatatcagc agtaatagaa ataattgaga aaatcatcta taaataatag atattacaga     7680

ctatagaata ccaaaataat gtcaatactg tagtttttaa agattttagg attaatctta     7740

gtccatataa atttgtacta ttggtaatta ttgaataatt gggaggaatc tgggcagttg     7800

tgctggttgt aaactatgaa tttctaatcg taaagtgaat tgttatttct aattgaactt     7860

tttttcaaga acagatttca gcctcacata ctaagtaaat actgataaat aaggaaatta     7920

gaaatttagt attcataatt aaatatgctc taaaatttcc tatactttta tttcctgttt     7980

attcttaggt agattggaag ggggaaacag tctgttctcc ctaattaaat tttttctaat     8040

aacgattagt agaatatgga cattctatat gacagtgaca ttaaaagagg ctctttggaa     8100

gtatatacat tattaacata atgtgtacaa gtccttttga aatgacaact ttaatgggtt     8160

tcagctcttt tatctagagc ttgagataat tcaagctgag tttttcaggg catatcacaa     8220

cggccaagtg ttcagcagtg ggatatcaat gcttatttac attttcctac tgctatttat     8280

ataaaatgtt attccattca gaggatgcct tttatcccca cattaaagca cagatcatta     8340

agcaataaaa accaaattgt ctgtcattca aattataact gcagttattt ttgcatggta     8400

agagtgaggt gctaattttg tgtgagatga actttgtaaa ctactttggg aaatgttctt     8460

tggaagtaag gttttttctc ctttagtctt atgcttccac ttttgtctca gattcacaat     8520

ccattaaaac atggggaaaa aagaaaaggt aaaattgaga gacttttgtt agaggagcta     8580

tttggaatga accaacattt cagattttcc aaaatgtaag ttaggaagtc tccattgtct     8640

ctgcattaac aaaatacact gttactatct taatctcaag agtgtcatta cagtgagaat     8700

ctcatttaaa agcataccag tgaaattaat agcagtgctt atcaaagaac actgaaatct     8760

gtgagaatct ttctaggagc attcttttct tcttttagtt ccaagttcca gggtattttt     8820

cattcctagt aggtttatat gactcacaga atgtggactt ttttcctgtt tggagtattt     8880

ttgtaatgta agtatcggat agctgcacca cagcatgcat aaattgcaca ttttgtttta     8940

ctttctttat agaatattta atttcaaaaa tataatttat gccaaaaaaa gcataccttt     9000

caattttgct acttggttga tttagcacaa aatgcaaagt cttggggcag agagggggag     9060

tgaaaaaaat tttataggta attgttacaa aaatacctgt cagaaaccct aaagctgcat     9120

tgtaaaacaa atggtgtaaa ctagttttga aaagtggtaa ggaattgtga aaaaaatctc     9180

agacttaatg ctctctaacc acatgagttt cttctttttt atttagtaat acgctgctac     9240

atatttggag gttctggtgt ttgtaggtca ctgaacagac attgaaatct gatttatatt     9300

gtataactgt aacatagaaa gaaaaagtat ttatattttt tctgtaagaa tatttcattg     9360

agttgtgtat aatttaaata agatttgtcc ccaaatggtt ttgctcacct tgattttttt     9420

tgttgtgatt ttcttgtttt tgtataatgt gtatagttta tgtcaagggc attaaaagcc     9480

tcctgaagca taatcttatc aaagggatac attgttaata aaatgtactt aaaattctta     9540

aac                                                                   9543


<210> 1414
<211> 5471
<212> DNA
<213> Homo sapiens

<400> 1414
gccctcttct gaagaggcgt ttctggacca ctgagccccg cctcccactg tgagcggaac       60

cctaccgttt ttaaaaaaat ctttttcaaa acttgccagg ttgtctttcc aaatattttt      120

aataatagtg ctgctgctgt agaccacaga gaaaagaatc cctcgctctt ccttttcact      180

tagtagaaac ttctaccgcg taggtcccgc caggagttcg cgcatgcgca ggagcgacaa      240

taagatggcg gtgataatcg ccgcactttt tttcaaatta gtggatccca gaaatcattg      300

cgcgcatttg taacgaattt ccgttcgagt ttgtatttta ggcgccattt tcgagtgaag      360

gacccggagc cgaaacaccg gtaggagcgg ggaggtgggt actacacaac cgtctccagc      420

cttggtctga gtggactgtc ctgcagcgac catgccccgt aaaggcaccc agccctccac      480

tgcccggcgc agagaggaag ggccgccgcc gccgtcccct gacggcgcca gcagcgacgc      540

ggagcctgag ccgccgtccg gccgcacgga gagcccagcc accgccgcag agactgcaag      600

tgaggaactt gataatagaa gtttagaaga gattttgaac agcattcctc ctcccccgcc      660

tccagcaatg accaatgaag ctggagctcc tcggcttatg ataactcata ttgtaaacca      720

gaacttcaaa tcctatgctg gggagaaaat tctgggacct ttccataagc gcttttcctg      780

tattatcggg ccaaatggca gtggcaaatc caatgttatt gattctatgc tttttgtgtt      840

tggctatcga gcacaaaaaa taagatctaa aaaactctca gtattaatac ataattctga      900

tgaacacaag gacattcaga gttgtacagt agaagttcat tttcaaaaga taattgataa      960

ggaaggggat gattatgaag tcattcctaa cagtaatttc tatgtatcca gaacggcctg     1020

cagagataat acttctgtct atcacataag tggaaagaaa aagacattta aggatgttgg     1080

aaatcttctt cgaagccatg gaattgactt ggaccataat agatttttaa ttttacaggg     1140

tgaagttgaa caaattgcta tgatgaaacc aaaaggccag actgaacacg atgagggtat     1200

gcttgaatat ttagaagata taattggttg tggacggcta aatgaaccta ttaaagtctt     1260

gtgtcggaga gttgaaatat taaatgaaca cagaggagag aagttaaaca gggtaaagat     1320

ggtggaaaag gaaaaggatg ccttagaagg agagaaaaac atagctatcg aatttcttac     1380

cttggaaaat gaaatattta gaaaaaagaa tcatgtttgt caatattata tttatgagtt     1440

gcagaaacga attgctgaaa tggaaactca aaaggaaaaa attcatgaag ataccaaaga     1500

aattaatgag aagagcaata tactatcaaa tgaaatgaaa gctaagaata aagatgtaaa     1560

agatacagaa aagaaactga ataaaattac aaaatttatt gaggagaata aagaaaaatt     1620

tacacagcta gatttggaag atgttcaagt tagagaaaag ttaaaacatg ccacgagtaa     1680

agccaaaaaa ctggagaaac aacttcaaaa agataaagaa aaggttgaag aatttaaaag     1740

tatacctgcc aagagtaaca atatcattaa tgaaacaaca accagaaaca atgccctcga     1800

gaaggaaaaa gagaaagaag aaaaaaaatt aaaggaagtt atggatagcc ttaaacagga     1860

aacacaaggg cttcagaaag aaaaagaaag tcgagagaaa gaacttatgg gtttcagcaa     1920

atcggtaaat gaagcacgtt caaagatgga tgtagcccag tcagaacttg atatctatct     1980

cagtcgtcat aatactgcag tgtctcaatt aactaaggct aaggaagctc taattgcagc     2040

ttctgagact ctcaaagaaa ggaaagctgc aatcagagat atagaaggaa aactccctca     2100

aactgaacaa gaattaaagg agaaagaaaa agaacttcaa aaacttacac aagaagaaac     2160

aaactttaaa agtttggttc atgatctctt tcaaaaagtt gaagaagcaa agagctcatt     2220

agcaatgaat cgaagtaggg ggaaagtcct tgatgcaata attcaagaaa aaaaatctgg     2280

caggattcca ggaatatatg gaagattggg ggacttagga gccattgatg aaaaatacga     2340

cgtggctata tcatcctgtt gtcatgcact ggactacatt gttgttgatt ctattgatat     2400

agcccaagaa tgtgtaaact tccttaaaag acaaaatatt ggagttgcaa cctttatagg     2460

tttagataag atggctgtat gggcgaaaaa gatgaccgaa attcaaactc ctgaaaatac     2520

tcctcgttta tttgatttag taaaagtaaa agatgagaaa attcgccaag ctttttattt     2580

tgctttacga gataccttag tagctgacaa cttggatcaa gccacaagag tagcatatca     2640

aaaagataga agatggagag tggtaacttt acagggacaa atcatagaac agtcaggtac     2700

aatgactggt ggtggaagca aagtaatgaa aggaagaatg ggttcctcac ttgttattga     2760

aatctctgaa gaagaggtaa acaaaatgga atcacagttg caaaacgact ctaaaaaagc     2820

aatgcaaatc caagaacaga aagtacaact tgaagaaaga gtagttaagt tacggcatag     2880

tgaacgagaa atgaggaaca cactagaaaa atttactgca agcatccagc gtttaataga     2940

gcaagaagaa tatttgaatg tccaagttaa ggaacttgaa gctaatgtac ttgctacagc     3000

ccctgacaaa aaaaagcaga aattgctaga agaaaacgtt agtgctttca aaacagaata     3060

tgatgctgtg gctgagaaag ctggtaaagt agaagctgag gttaaacgct tacacaatac     3120

catcgtagaa atcaataatc ataaactcaa ggcccaacaa gacaaacttg ataaaataaa     3180

taagcaatta gatgaatgtg cttctgctat tactaaagcc caagtagcaa tcaagactgc     3240

tgacagaaac cttcaaaagg cacaagactc tgtcttgcgt acagagaaag aaataaaaga     3300

tactgagaaa gaggtggatg acctaacagc agagctgaaa agtcttgagg acaaagcagc     3360

agaggtcgta aagaatacaa atgctgcaga ggaatcctta ccagagatcc agaaagaaca     3420

tcgcaatctg cttcaagaat taaaagttat tcaagaaaat gaacatgctc ttcaaaaaga     3480

tgcacttagt attaagttga aacttgaaca aatagatggt cacattgctg aacataattc     3540

taaaataaaa tattggcaca aagagatttc aaaaatatca ctgcatccta tagaagataa     3600

tcctattgaa gagatttcgg ttctaagccc agaggatctt gaagcgatca agaatccaga     3660

ttctataaca aatcaaattg cacttttgga agcccggtgt catgaaatga aaccaaacct     3720

cggtgccatc gcagagtata aaaagaagga agaattgtat ttgcaacggg tagcagaatt     3780

ggacaaaatt acttatgaaa gagacagttt tagacaggca tatgaagatc ttcggaaaca     3840

aaggcttaat gaatttatgg caggttttta tataataaca aataaattaa aggaaaatta     3900

ccaaatgctt actttgggag gggacgccga actcgagctt gtagacagct tggatccttt     3960

ctctgaagga atcatgttca gtgttcgacc acctaagaaa agttggaaaa agatcttcaa     4020

cctttcggga ggagagaaaa cacttagttc attggcttta gtatttgctc ttcaccacta     4080

caagcccact cccctttact tcatggatga gattgatgca gcccttgatt ttaaaaatgt     4140

gtccattgtt gcattttata tatatgaaca aacaaaaaat gcacagttca taataatttc     4200

tcttcgaaat aatatgtttg agatttcgga tagacttatt ggaatttaca agacatacaa     4260

cataacaaaa agtgttgctg taaatccaaa agaaattgca tctaagggac tttgttgaac     4320

tttatgctga agattcttca agttgattca gtgtattact gatttttttc tatttgtaaa     4380

ggattatgag ttgtataaaa tacatactcc ctaaactaga tcatgaaact ggtttctgtt     4440

ttatgcagtt gtcatttgta aagtctaata aaatattctc tataattgct tctagattac     4500

aaaaatatga caatcttgta agtagcagac tatggagaaa aatgagttac ctggagggtc     4560

aggtaacttg ccaaactaaa aagtatgtta gttgaggcaa agtcctaagc aaggttgtgc     4620

tatcaaggct cagcatacct tcgtgggcct ttgatttacc aacactggaa atgcctgcca     4680

actaatcttg gatagattct ttaaggcatt ccacttagct tgccagttga gacaatcacc     4740

acagttatta cccaaatact atgaacatat ttttgtaaac cagtcattct gaattatagt     4800

gatgagaatt taaatatatg cttttctaga atttgatgtt tgaccattta tgacttaatt     4860

accagagagc cagtaaatta ggacagtgtt tcaacaagcc taggctatct cgtaagttga     4920

aaaatatccc actatagttg cttcatgagt atgaagtaag atggcctctg atttacactg     4980

gttcaattta caaattttca actttatgat aggtttatcc gggtactaaa tgcatttcaa     5040

cttgatagtt tcaacttatg ataggtttac caggatgtag tcccactgtt gaggagcatc     5100

tatttagggg ttaattactt tagtaataag tggaaagtaa gataccttga gtaatgtttg     5160

cctataaaat tgtcagcgta tttttacact attggctcaa gaatgttata atgctaaggg     5220

acataagttg gcaaccactt ggtttttgga aggactttcg gtattgtatt agaagtctgc     5280

cctagctgtt aaatttctgg gtatttatcc taaggaatta attaaagagt taattgttcc     5340

tttcttcagt gggccattgt tttagatatt taaaaaatcc aacagtttct atcataatgt     5400

aactgtaaaa atgtaaacac attattagca tggactttta aataaagatt taaagaaagc     5460

aagatcggaa a                                                          5471


<210> 1415
<211> 4155
<212> DNA
<213> Homo sapiens

<400> 1415
atgacaggat caaattcaca cataacgata ttaaccttaa aggtgttacc tcattttgaa       60

agtcttggga aacaggaaaa aattcctaac aaaatgtcag cttttcgaaa tcattgtcca      120

catttggatt cagttggtga aataacaaaa gaagatttga tacaaaaatc ccttggtact      180

tgtcaggatt gtaaagtcca aggaccaaat ctttgggcat gtctggagaa tagatgttca      240

tatgttggct gtggtgaatc acaagtagat cacagcacca tacattctca ggagacaaag      300

cattatctaa ctgtgaacct taccactctt cgagtatggt gttatgcttg cagcaaagaa      360

gtatttttgg ataggaaatt aggaactcag ccttcattgc ctcatgtaag acaacctcac      420

caaatacaag aaaacagtgt ccaggatttt aaaataccca gtaatacaac attaaaaact      480

cctctggttg ccgtatttga tgatctggat atagaagcgg atgaagaaga tgaacttagg      540

gccagaggtc ttacaggttt gaaaaatatt ggaaatactt gttacatgaa tgcagctttg      600

caggctcttt ctaattgccc acctttgaca cagttttttc ttgattgtgg aggactagct      660

cgaacagata agaaacctgc catttgtaaa agttatctca aactaatgac agagctgtgg      720

cataaaagca ggccaggatc tgttgtgcct actactctgt ttcaaggaat taaaactgta      780

aatccaacat ttcgggggta ttctcagcag gatgctcaag aattccttcg atgtttaatg      840

gatttgcttc atgaagaatt gaaagagcaa gtcatggaag tagaagaaga tccgcaaacc      900

ataaccactg aggagacaat ggaagaagac aagagccagt cggatgtaga ttttcagtct      960

tgtgaatctt gtagcaacag tgatagagca gaaaatgaaa atggctctag atgcttttct     1020

gaagataata atgaaacaac aatgttaatt caggatgatg aaaacaattc agaaatgtca     1080

aaggattggc aaaaagagaa gatgtgcaat aagattaata aagtaaattc tgaaggcgaa     1140

tttgataaag atagagactc tatatctgaa acagtcgact taaacaacca ggaaactgtc     1200

aaagtgcaaa tacacagcag agcttcagaa tatatcactg atgtccattc gaatgacctg     1260

tctacaccac agatccttcc atcaaatgaa ggtgttaatc cacgtttatc ggcaagccct     1320

cctaaatcag gcaatttgtg gccaggattg gcaccaccac acaaaaaagc tcagtctgca     1380

tctccaaaga gaaaaaaaca gcacaagaaa tacagaagtg ttatttcaga catatttgat     1440

ggaacaatca ttagttcagt gcagtgtctg acttgtgaca gggtgtctgt aaccctcgag     1500

acctttcaag atctgtcctt gccaattcct ggcaaggaag accttgctaa gctgcattca     1560

tcaagtcatc caacttctat agtcaaagca ggatcatgtg gcgaagcata tgctccacaa     1620

gggtggatag cttttttcat ggaatatgtg aagaggtttg ttgtctcatg tgtccctagc     1680

tggttttggg gtccagtagt aaccttgcaa gattgtcttg ctgccttctt tgccagagat     1740

gaactaaaag gtgacaatat gtacagttgt gaaaaatgca aaaagttgag aaatggagtg     1800

aagttttgta aagtacaaaa ctttcctgag attttgtgca tccaccttaa aagattcaga     1860

catgaactaa tgttttccac caaaatcagt acccatgttt catttccgct agaaggcttg     1920

gatcttcagc catttcttgc taaggatagt ccagctcaaa ttgtgacata tgatcttctg     1980

tcagtcattt gccatcatgg aactgcaagt agtggacact atatagccta ctgccgaaac     2040

aatctaaata atctctggta tgaatttgat gatcagagtg tcactgaagt ttcagaatct     2100

actgtacaaa atgcagaagc ttacgttctt ttctatagga agagcagcga agaggcacaa     2160

aaagagagga gaaggatatc aaatttattg aacataatgg aaccaagcct ccttcagttt     2220

tatatttctc gacagtggct taataaattt aagacctttg ccgaacctgg ccctatttca     2280

aataatgact ttctttgtat tcatggaggt gttcctccaa gaaaagctgg ttatattgaa     2340

gacctggttt tgatgctgcc tcagaacatt tgggataacc tatatagcag gtatggtgga     2400

ggaccagctg tcaaccatct gtacatttgt catacttgcc aaattgaggc ggagaaaatt     2460

gaaaaaagaa gaaaaactga attggaaatt tttattcggc ttaacagagc gttccaaaaa     2520

gaggactctc cagctacttt ttattgcatc agtatgcagt ggtttagaga atgggaaagt     2580

tttgtgaagg gtaaagatgg agatcctcca ggtcctattg acaatactaa gattgcagtc     2640

actaaatgtg gtaatgtgat gcttaggcaa ggagcagatt ctggccagat ttctgaagaa     2700

acatggaatt ttctgcagtc tatttatggt ggagggcctg aagttatcct gcgacctccg     2760

gttgttcatg ttgatccaga tatacttcaa gcagaagaaa aaattgaagt agaaactcgg     2820

tctttgtaat ttttaggatg tagagagttc taatgaggaa tcattttcat gtgccctgac     2880

atgtacacat gcgaaaacat tcctaaaagc gtgtttattt gctttatttt ttttcatcat     2940

ttatcccatt tatttcttct tagtgggcat tatggaagaa tatattaaaa tgtgtaatat     3000

accacaggtt ggtatattta gttttaaata cttaccataa agtctttcag tgtaattttt     3060

ttttgagaca gagtcttgct ttgtcaccca ggctggagtg ctgtggtgtt acctcagctc     3120

actgcagcct ccacctcctg ggttcaagcg attctcctgc ctcagcctct cgagtagctg     3180

ggattacagg cacctgccac catgcccggc taatttttgt attttagtag agatggggtt     3240

tcaccatgtt ggccaggcta gtctcaaact cctgacctca ggtgatccac ccacctcggc     3300

ctcccaaagt gctgggatta caggtgtgag ccacagcgcc tggcccagtg taatattttt     3360

gaaagaggag ggacaattgt gaaatcagta ggttatcttt aatctttaca ctacatgcag     3420

atccatagta tcctttgtag tgttgtaaat acttttgctt tgaaaacttt ttcattgtcc     3480

taaatcaccc tgactctgac cagtctttca gttctccaaa agcccaattt aattgtatag     3540

ttttgtcatg gcttcatata ataaagagcc tattttaagt tgaaagtagt agtcagaaaa     3600

ttgttaattt cctaaagctc aggaaactag ggtgtcactt tttttgcact gcagcatata     3660

cactaactag cttattaaaa tttacaaaat gtctttttga atgtatcaag gatatattta     3720

gtttgagtgg aatttgtcag cagatatcag taacttattg ccgcttatat tgtacaatgt     3780

taaacttcaa ttcctgtaac ctggttagta ttaatgtcag tgactaaaaa acttagagtt     3840

agttttaggg cactttttat tttgagagca tgaagtgtgg aatgtgtcac tacgattgtt     3900

gataaagctg aggccacttg caacttgatt ttttaaatga aatagataaa gtctttttga     3960

ataatatagt atgcactgct atttgcttga ttatgtaatg tcaaaagttt aactatattc     4020

caagtacaaa aacatactgg attacattga ggatgttgaa tagcattcat gatggctttg     4080

ttttggtttg gggcagctgt caccagctaa agcaatgttg ttaaaattag ctcaataaaa     4140

atgtctttaa aatgt                                                      4155


<210> 1416
<211> 2852
<212> DNA
<213> Homo sapiens

<400> 1416
aacctgtgga cggccgcggc cggcggacac acagcagcgg gggcccggcc gggggtcgcc       60

cgggggcccg gaagccgggg aagagcgagg aaaccaactt ggagagagga gtgacctggg      120

ggccgggggc ggagtcgtga gcgggggagg agagagccgg ccgccagcaa gagccgcgcg      180

gcggcccagg aagcgagagc gccgcccacc catccggggc aagagccgcg ccgcaggaga      240

ggcaggctgg accgggggct ccccgggccc gcgacccccg ccgtgacccc gcagccccca      300

gctcgccccc aagatgatga agaggcagct gcaccgcatg cggcagctgg cccagacggg      360

cagcttggga cgcaccccgg agaccgctga gttcctgggt gaggacctgc tgcaggtaga      420

acagcggctg gagccggcca agcgggcagc ccacaacatc cacaagcggc tgcaggcctg      480

tctgcagggc cagagcgggg cagacatgga caagcgggtg aagaagcttc ccctcatggc      540

tctgtccacc acgatggctg agagcttcaa ggagctggac cctgattcca gcatggggaa      600

ggccttggag atgagctgtg ccatccagaa tcagctggcc cgcatcctgg ccgagtttga      660

gatgaccctg gagagggacg tcctgcagcc actcagcagg ctgagtgagg aggagctgcc      720

agccatcctc aaacacaaga aaagcctcca gaagctcgtg tccgactgga acacactcaa      780

gagcaggctc agtcaggcaa ccaagaattc aggcagcagt caaggcctag gaggcagccc      840

gggtagtcac agccatacga ccatggccaa caaggtggag acgctgaagg aggaggagga      900

ggagctgaag aggaaagtgg agcaatgcag ggacgagtac ttggctgacc tgtaccactt      960

tgttaccaag gaggactcct atgccaacta cttcattcgt ctcctggaga ttcaggccga     1020

ttaccatcgc aggtcactga gctcgctgga cacagccctg gctgagctga gggagaacca     1080

cggccaagca gaccactccc cttcgatgac agccacccac ttccccaggg tgtatggggt     1140

gtcgctggca acccacctgc aagagctggg ccgggagatt gccctgccca tcgaggcctg     1200

cgtcatgatg ctgctttctg agggcatgaa ggaagagggt ctcttccgtc tggctgctgg     1260

ggcctcggtg ctgaagcgtc tcaagcagac aatggcctcg gacccccaca gcctggagga     1320

gttctgctcc gacccgcacg ctgtggcagg tgccctcaag tcctatctgc gggagctgcc     1380

agagcctctg atgaccttcg acctctatga tgactggatg agggcagcca gcctgaagga     1440

gccaggggcc cggctgcagg ccctccaaga ggtgtgcagc cgcctacccc ccgagaacct     1500

cagcaacctc aggtacctga tgaagttcct ggcacggctg gccgaggagc aggaggtgaa     1560

caagatgaca cccagcaaca tcgccatagt cctgggaccc aacttgctgt ggccacctga     1620

gaaagaaggg gaccaggccc agctggatgc agcctccgtg tcttccatcc aggtggtggg     1680

cgtcgtcgag gcgctgatcc agagcgcaga caccctcttc cctggagaca tcaacttcaa     1740

cgtgtcaggc ctcttctcag ctgttaccct ccaggacaca gtcagtgaca ggctggcctc     1800

tgaggaactt ccgtccactg ccgtgcccac cccagccacc accccggctc cggctccggc     1860

tccagctcca gctccggccc cagccttggc ttcagcagct accaaggaaa ggacagagtc     1920

tgaggtgcct cccagaccag cctcccccaa ggtcaccagg agtcccccgg agacagctgc     1980

cccagtggag gacatggctc ggaggaccaa gcgcccggcg ccagcccggc ccaccatgcc     2040

gcccccccag gtctccggct cccgctcctc ccctccagcc ccgcccttgc cccctggctc     2100

tggcagccct gggacccccc aagccctgcc ccgacgtctg gttggcagca gcctccgagc     2160

ccccacagtg ccacccccgt taccccccac accccctcag cctgcccggc gccaaagccg     2220

gcgttcacca gcctccccca gcccggcctc cccaggtcca gcctccccca gcccagtctc     2280

tttgagtaac cctgcacagg tggacctggg ggctgccaca gcagagggag gagcccctga     2340

ggctatcagt ggggtcccca ctcccccagc tatcccccct cagccccgcc ccaggagcct     2400

tgcctcagag accaactgag tggctggttt ctccctaagc agccctcagc accccctccc     2460

tccccacctg gccctcccag gacagctctc gccccccaca aaggggcatg ggcctccagc     2520

ctttgcccac aagtgcctca gtgcccactg ggtcggcccc catggccagg agggctcagg     2580

acaatcctct atttcctgac cttttcctcg tccaccctgg gcttggggac ccccccaccg     2640

gactctccac tctccggcag gtcctagggg agccaccgga aggaaggaga ggtttgcctg     2700

ctcctacggg actgattctt ctcttgccga catgtttttt gtaaggctgg taaataaatt     2760

attttggaca aaactggagc agctgcccaa atgatagttt tattttctgt ccttgaaata     2820

aagaagccaa ttttataaag gggaaaacaa ta                                   2852


<210> 1417
<211> 2605
<212> DNA
<213> Homo sapiens

<400> 1417
ggcctggacg agcgcgcttc cgacccgccg ccaccgcctc ctcccctcct tctcggcccg       60

ccccctccct cgcctcttcc tgccaggcgg cccttctccc ctcccctctc agttccctcc      120

gccctcctcg ggctccagcg gtggcggagc gaacgggacc ggcccggctt cagagcgcga      180

ggtggagggt ggaacgcggg cgcctgaagg agttgttgtc tcggcagcgc ccgcggagac      240

gtgaagaggt ggttgtggga agagaagttt gcagaactga aatggaggtc agagcttcat      300

tacagaagat agtttctaat ggtgatgaac aattggaaaa agccatggaa gagattttga      360

gagattccga gaaaaggcca agcagtcttc ttgttgattg tcaaagttcc agtgagattt      420

cagaccattc gtttggagat attccagcca gccaaacaaa taagccatct cttcagttaa      480

ttttggatcc gtctaacaca gaaatttcta cacccagacc atcttctcca ggtggactac      540

ctgaagaaga tagtgtttta tttaataaac tgacctactt aggatgtatg aaggtttctt      600

ccccacgtaa tgaagtagag gctttacggg caatggcaac catgaaatct tccagtcaat      660

acccctttcc tgttaccctg tatgtaccaa atgttccaga aggttctgtg agaattatag      720

accaatccag caatgtggag atagcatctt ttccaatcta taaggtgtta ttctgtgcac      780

gtggacatga cggaacaaca gagagcaatt gctttgcatt tacagagagt tcccatggtt      840

cggaagaatt tcagatacat gttttctcct gtgaaattaa agaggcagta agcagaattt      900

tgtacagttt ctgtacagca ttcaaacgtt cttccagaca agtgtctgat gttaaagact      960

cagttattcc tacccccgac agtgatgtgt ttaccttcag tgtctccttg gaggtaaaag     1020

aagacgatgg aaaaggaaac tttagccctg tgcctaagga tagagataaa ttttatttca     1080

aattaaagca aggaatagag aagaaggttg tgattacagt gcagcaactt tctaacaaag     1140

aattagctat tgaaagatgt tttggaatgt tattaagccc aggtcgaaac gtgaagaaca     1200

gtgacatgca tttactggat atggaatcca tgggaaagag ctatgatggg agagcttatg     1260

tcatcactgg catgtggaac cccaatgcac cagtatttct ggcacttaac gaggaaaccc     1320

caaaagataa gcaagtatac atgactgtgg cagtggatat ggtagtcaca gaggtggtgg     1380

agcctgttcg ctttctcctg gagacagtag tccgtgtgta ccctgcaaat gagcgatttt     1440

ggtatttcag cagaaagact ttcacagaga ctttcttcat gagattgaaa cagtctgagg     1500

gaaaaggcca taccaatgct ggagatgcaa tatatgaggt ggtgagtcta cagcgagagt     1560

ctgacaagga ggaaccagtc actcctacta gtggaggggg tccaatgtca ccccaggatg     1620

atgaagcaga agaggagagt gataatgaac tctcaagtgg aacaggtgat gtgtctaagg     1680

attgtcctga gaagatcctg tattcttggg gagagttgct aggaaaatgg cacagtaacc     1740

ttggtgcacg accgaaaggg ctgtctactc tggtgaagag tggtgtccct gaagcattga     1800

gggcagaggt atggcagtta ttggcaggct gccatgacaa ccaggcaatg ctggatagat     1860

accgaattct tatcacaaag caacagatga aatttagtct tacaccgaga cagactattc     1920

acctagttaa atatgaaggg tctatgaagg tctccatgac accctgtaac cagctgcaat     1980

ttgacattag acttgatgtt ctgattactt atactttttg ttttagttcc tttcctgagc     2040

ctgaattgta caaatatgtc ctaaaacacc aacttattaa gaggcttaat gcctgttaaa     2100

tgcgtcagtg ctcttggcag cttagcatga gtgctttctt tgcatgggag gttgcagttt     2160

agaagcaact ttatggatca tttcccaggt tgatgttaca tatgttcatt ttacaacctg     2220

tgtgcataat ctctcagggt gaaggtaatt aagagaaagc ataatctaca gaattgaagc     2280

caagtaatct aagattctgt ttttaaactc tttgctatat aacattagtt aagttgttta     2340

ccctcttaat ttatccattt gtaaaatgat agtttttgtt tttaaagtgc tctattaccc     2400

ttactttaaa agtcctgtct accatatatt taaaactata agtggaaata atgaagaaac     2460

tctgaacttg cttttgctta tatatggata tatcatatta tatgcctaag attggagata     2520

aattttataa cctgattttc tcatggcagt gtacaaatga aattattctg taagtttttc     2580

aaaacagtaa aatcactatt tttca                                           2605


<210> 1418
<211> 6815
<212> DNA
<213> Homo sapiens

<400> 1418
gaacgctcac agaacaggca gtgcaattcc atgttcctct taagtatgtt agccctaccg       60

ggagctgagc tggccagtct acttggagag gaaaagtaga tctggggaag gtggaagggt      120

cagttcctaa gtgacttcct cctcggggat ggtaagggca tttgctgatc tccagtgact      180

gcctggtgcc tcatggtcag actcggctgt ctcactccca gatatctgat tttgcaaaaa      240

gggacacacc tatctgcagc aaagaagaca ctgaccagat tgcgagcggt gcttttggat      300

gctctgtagc cacccggggc ccaggaggac tgactcggca gcaggattcg tgcatgggaa      360

tcggagacca tggcagtgca gctggtgccc gactcagctc tcggcctgct gatgatgacg      420

gagggccgcc gatgtcaagt acatcttctt gatgacagga agctggaact cctagtacag      480

cccaagctgt tggccaagga gcttcttgac cttgtggctt ctcacttcaa tctgaaggaa      540

aaggagtact ttggaatagc attcacagat gaaacgggac acttaaactg gcttcagcta      600

gatcgaagag tattggaaca tgacttccct aaaaagtcag gacccgtggt tttatacttt      660

tgtgtcaggt tctatataga aagcatttca tacctgaagg ataatgctac cattgagctt      720

ttctttctga acgcgaagtc ctgcatctac aaggagctta ttgacgttga cagcgaagtg      780

gtgtttgaat tagcttccta tattttacag gaggcaaagg gagatttttc tagcaatgaa      840

gttgtgagga gtgacttgaa gaagctgcca gcccttccca cccaagccct gaaggagcac      900

ccttccctgg cctactgtga agacagagtc attgagcact acaagaaact gaacggtcag      960

acaagaggtc aagcaatcgt aaactacatg agcatcgtgg agtctctccc aacctacggg     1020

gttcactatt atgcagtgaa ggacaagcag ggcataccat ggtggctggg cctgagctac     1080

aaagggatct tccagtatga ctaccatgat aaagtgaagc caagaaagat attccaatgg     1140

agacagttgg aaaacctgta cttcagagaa aagaagtttt ccgtggaagt tcatgaccca     1200

cgcagggctt cagtgacaag gaggacgttt gggcacagcg gcattgcagt gcacacgtgg     1260

tatgcatgtc cggcattgat caagtccatc tgggctatgg ccataagcca acaccagttc     1320

tatctggaca gaaagcagag taagtccaaa atccatgcag cacgcagcct gagtgagatc     1380

gccatcgacc tgaccgagac ggggacgctg aagacctcga agctggccaa catgggtagc     1440

aaggggaaga tcatcagcgg cagcagcggc agcctgctgt cttcaggttc tcaggaatca     1500

gatagctcgc agtcggccaa gaaggacatg ctggctgcct tgaagtccag gcaggaagct     1560

ctggaggaaa ccctgcgtca gaggctggag gaactgaaga agctgtgtct ccgagaagct     1620

gagctcacgg gcaagctgcc agtagaatat cccctggatc caggggagga accacccatt     1680

gttcggagaa gaataggaac agccttcaaa ctggatgaac agaaaatcct gcccaaagga     1740

gaggaagctg agctggaacg cctggaacga gagtttgcca ttcagtccca gattacggag     1800

gccgcccgcc gcctagccag tgaccccaac gtcagcaaaa aactgaagaa acaaaggaaa     1860

acctcgtatc tgaatgcact gaagaaactg caggagattg aaaatgcaat caatgagaac     1920

cgcatcaagt ctgggaagaa acccacccag agggcttcgc tgatcataga cgatggaaac     1980

attgccagtg aagacagctc cctctcagat gcccttgttc ttgaggatga agactctcag     2040

gttaccagca caatatcccc cctacattct cctcacaagg gactccctcc tcggccaccg     2100

tcgcacaaca ggcctcctcc tccccagtcc ctggagggac tccgacagat gcactatcac     2160

cgcaacgact atgacaagtc acccatcaag cccaaaatgt ggagtgagtc ctctttagat     2220

gaaccctatg agaaggtcaa gaagcgctcc tctcacagcc attccagcag ccacaagcgc     2280

ttccccagca caggaagctg tgcggaagcc ggcggaggaa gcaactcctt gcagaacagc     2340

cccatccgcg gcctcccgca ctggaactcc cagtccagca tgccgtccac gccagacctg     2400

cgggtccgga gtccccacta cgtccattcc acgaggtcgg tggacatcag ccccacccga     2460

ctgcacagcc tcgcactgca ctttaggcac cggagctcca gcctggagtc ccagggcaag     2520

ctcctgggct cggaaaacga caccgggagc cccgacttct acaccccgcg gactcgtagc     2580

agcaacggct cagaccccat ggacgactgc tcgtcgtgca ccagccactc gagctcggag     2640

cactactacc cggcgcagat gaacgccaac tactccacgc tggccgagga ctcgccgtcc     2700

aaggcgcgcc agaggcagag gcagcggcag cgggcggcgg gcgcactggg ctcagccagc     2760

tcgggcagca tgcccaacct ggcggcgcgc gggggtgcgg ggggcgcggg gggcgcgggg     2820

ggcggtgtgt acctgcacag ccagagccag cccagctcgc agtaccgcat caaggagtac     2880

ccgctgtaca tcgagggcgg cgccacgccc gtggtggtgc gcagcctgga gagcgaccag     2940

gagggccact acagcgtcaa ggctcagttc aagacgtcca actcctacac ggcgggcggc     3000

ctgttcaagg agagctggcg cggcggcggc ggcgacgagg gcgacacggg ccgcctgacg     3060

ccgtcgcgat cgcagatcct gcggactccg tcgctgggcc gcgagggcgc ccacgacaag     3120

ggcgcgggcc gtgccgccgt ctcagacgag ctgcgccagt ggtaccagcg ttccaccgcc     3180

tcgcacaagg agcacagccg cctgtcgcac accagctcca cctcctcgga cagcggctcg     3240

cagtacagca cctcctccca gagcaccttc gtggcgcaca gcagggtcac caggatgccc     3300

cagatgtgca aggccacgtc agctgcctta cctcaaagcc agagaagctc gacaccgtca     3360

agtgaaattg gagccacccc cccaagcagc ccccaccaca tcctaacctg gcagactgga     3420

gaagcaacag aaaactcacc cattctggat gggtctgagt ctccacctca ccaaagtact     3480

gatgaataga ggagctacaa tgatagctgt ttcctggatt cctccctcta tccagaacta     3540

gctgatgtcc agtggtacgg gcaggaaaaa gccaagcccg ggaccctcgt gtgagccagc     3600

ccggcctaat ctgaccgcct caacgccatt ctgagatcac ctcactgcct ctcatttgcc     3660

ttacccagac gcaccgtcac cctgcaccag ctttggccct cagcactttt tttctcctgt     3720

ctccgcattc cctccccctt gaaaacctga ctgaggagac attctggaag gttccggtcc     3780

cactgtgtgt cccctggcgc tcttgcccat agagagccag acaccaatcc tcaatggcac     3840

cttggtggct tccctctgcc atgacagccc ctaggccagg aaccatcagg ggggccagcc     3900

ggcatccaat tcctgcggat aagtagcgtt gggagagaac gggaaagggg acttgagtta     3960

cagggtgacc cagaaagacg attcagctgt gtccagcctg ccacccatac gtaggccaac     4020

caagcacttc atgaagagga ggcctcgtgg catattcagt ttacacctga aatattcctt     4080

gatgggacag cttgtgggga tggctatggg ggaaggggag gttgagaaag gaagttctcg     4140

acaccagaaa tgcatcggag gaccacaatc agttctatgc tgccaaagat taaaaataaa     4200

taaaaacata aaaaattaag aggggccaag aggaagacat tctttctgca aggaaatttc     4260

ttttaaattc tgaactgcta ctacacacaa gtgaaagtca accctatgta aactggtgtc     4320

ctctctctag ccctctccct tactggccca cttctctctc cgtagagagc ctgaaaaact     4380

gccccaatgc cacggtaaag gcgaggaagt cttggctggc gttgctgact cacagtcgcc     4440

atccatctgg acacaaagag agacctgtgg gagtcgtaga gggtactgtt agccccggtc     4500

catgcagggg gttcagccga gcccaagact caaagctgct ttcctttcag gatttgtagt     4560

aacgtaaggt gataatggcc aaaagtggtt ctctctcatt aaaccaacca gtaaaagcgt     4620

atcctatttt tttgcacaag gtgtttcatt ttcgttttta tgggaaacca agggaaaagc     4680

acattgcgat ccattcagtg tttaactgtc gtggctcatt ttctgttcgt tagcacttgt     4740

gtgacaaaag agctcagatc cgacttctcc tatgtgtcac ttattccaag aacccaacta     4800

tgcccttagg tagaaagatt tgactcgtgt gtctactagc caacaggcag agcagggttg     4860

aaaaaaatat cagctcccaa agggcccatg tgtctacatc atcagttact gtcatgcacc     4920

acatttgtgt gcagatacca aaagaggagg aaagaagaaa aaaattaatg tgtgggagct     4980

gcacgtttac atgttttgag ctatgcttca aacacaactg gaaagccatc aatcttcaaa     5040

ggcctcaaaa atacttttat agtaacaagt gcacgacttt agttgggtta ttcaagatgg     5100

cacaaaaagg tttccgcaga ggtggtatgc tgtgcttttg gcgcaagtgg tggggggatg     5160

gggtgggggt ggaatttttt tctcactcta atgacttcct attggaaagg cattgacagc     5220

cagggacagg agccagggtg ggggtagttt tgtgggaaag cagaactgaa gttagcttaa     5280

gcataaaaac aaagaaaaat cttcgctttt catgtatgtg gaatccaaga ataaccatag     5340

gctctaccag accagaaggg taaggatgga cactaaaatg aaacaaatac caaggtattc     5400

cttctgctgc agcctggaga ccaccgagag tcgagctggg gcacacacac acctggccgg     5460

gacccggcag ggacaaggcg ggccgtggcc tcctccacca agtctctcta gacaattcag     5520

ggcctgcttt ccccagctcc atgcatggct ggactggtga ttccagggtg cagaagggat     5580

tcatattccc agaacgcttt aagtgtacac ctgcaggata aagagatacc ggttacatta     5640

ttaaatgatt ctagggattc actgggggat atttttgttg cttttacttt catggttaga     5700

gctacaaaga acagtgattt tttttttttc tcccttcccc attcagaaac attatacatt     5760

gggccatttt tctttctccc aaagaagatt catggatagt cagactgaac tgtgtgcaac     5820

aggaaaagtc aaaagggaaa aggtagctga tgaggttaca tggttacatg ttctacatca     5880

tgcatagtag cttgaaatct agtctggaga aaactggatc aagattctag cccactggag     5940

ttgcaaggaa tgagaggcaa aaattctaaa gatttgggtt atattttcaa cttgggggac     6000

agagagaaat ggagagcagg aattacagtt ccaacaaaca tcatgatagt ctggtagtca     6060

agacagagat taagtaaaac aggttttact gtttagctga gttcagttaa tacaaaatgt     6120

acataaaacg ttagtccttt gagactgaca tgattaatga tcagtgtggt gggaaatgat     6180

gtagttattg tacacaagca cttgcaaact ctttatccct atttctttaa aacaaaataa     6240

ggtgaaatac gaagtccttg gtctgatata aagcccctat tggattcttc ggatgcgtaa     6300

aagaaattgc ctgtttcagc cagaagactg gtgaaaacac atacatcaga ctatgttgtg     6360

agccaggttg attttttatt ttattatatg caggtgagtg ttgaaactgt taaaattcca     6420

atttgttttc attcagtatt agtttagttc taaatatagc aaaccccatc caggtgctat     6480

cagatgacca gttactgctt agttaactag gtgtaaagtt ttacatatac attaatgtca     6540

atagtttatt acaagttgtg taaaatggac tctagtttaa taatggggga aaaaagatta     6600

ggttgctcct gaaactgact gtagagcatg taaaatgatt ttactggatt ctgttcaact     6660

gtaatcaatg aaaaagatgt acgttgtaga caaagttgca gaattaaaaa aagaaatctg     6720

cttttaattt attctttttg tattaagaat ttgtatagta cctttacatt ttgcaaaaca     6780

gtgttgtcaa cacttattaa agcattttca aaatg                                6815


<210> 1419
<211> 4031
<212> DNA
<213> Homo sapiens

<400> 1419
gattggaaac ccggagttac ctgctagttg gtgaaactgg ttggtagacg cgatctgttg       60

gctactactg gcttctcctg gctgttaaaa gcagatggtg gttgaggttg attccatgcc      120

ggctgcctct tctgtgaaga agccatttgg tctcaggagc aagatgggca agtggtgctg      180

ccgttgcttc ccctgctgca gggagagcgg caagagcaac gtgggcactt ctggagacca      240

cgacgactct gctatgaaga cactcaggag caagatgggc aagtggtgcc gccactgctt      300

cccctgctgc agggggagtg gcaagagcaa cgtgggcgct tctggagacc acgacgactc      360

tgctatgaag acactcagga acaagatggg caagtggtgc tgccactgct tcccctgctg      420

cagggggagc agcaagagca aggtgggcgc ttggggagac tacgatgaca gtgccttcat      480

ggagcccagg taccacgtcc gtggagaaga tctggacaag ctccacagag ctgcctggtg      540

gggtaaagtc cccagaaagg atctcatcgt catgctcagg gacactgacg tgaacaagca      600

ggacaagcaa aagaggactg ctctacatct ggcctctgcc aatgggaatt cagaagtagt      660

aaaactcctg ctggacagac gatgtcaact taatgtcctt gacaacaaaa agaggacagc      720

tctgataaag gccgtacaat gccaggaaga tgaatgtgcg ttaatgttgc tggaacatgg      780

cactgatcca aatattccag atgagtatgg aaataccact ctgcactacg ctatctataa      840

tgaagataaa ttaatggcca aagcactgct cttatatggt gctgatatcg aatcaaaaaa      900

caagcatggc ctcacaccac tgttacttgg tgtacatgag caaaaacagc aagtcgtgaa      960

atttttaatt aagaaaaaag cgaatttaaa tgcactggat agatatggaa gaactgctct     1020

catacttgct gtatgttgtg gatcagcaag tatagtcagc cttctacttg agcaaaatat     1080

tgatgtatct tctcaagatc tatctggaca gacggccaga gagtatgctg tttctagtca     1140

tcatcatgta atttgccagt tactttctga ctacaaagaa aaacagatgc taaaaatctc     1200

ttctgaaaac agcaatccag aacaagactt aaagctgaca tcagaggaag agtcacaaag     1260

gttcaaaggc agtgaaaata gccagccaga gaaaatgtct caagaaccag aaataaataa     1320

ggatggtgat agagaggttg aagaagaaat gaagaagcat gaaagtaata atgtgggatt     1380

actagaaaac ctgactaatg gtgtcactgc tggcaatggt gataatggat taattcctca     1440

aaggaagagc agaacacctg aaaatcagca atttcctgac aacgaaagtg aagagtatca     1500

cagaatttgt gaattacttt ctgactacaa agaaaagcag atgccaaaat actcttctga     1560

aaacagcaac ccagaacaag acttaaagct gacatcagag gaagagtcac aaaggcttaa     1620

aggcagtgaa aatggccagc cagagaaaag atctcaagaa ccagaaataa ataaggatgg     1680

tgatagagag ctagaaaatt ttatggctat cgaagaaatg aagaagcaca gaagtactca     1740

tgtcggattc ccagaaaacc tgactaatgg tgccactgct ggcaatggtg atgatggatt     1800

aattcctcca aggaagagca gaacacctga aagccagcaa tttcctgaca ctgagaatga     1860

agagtatcac agtgacgaac aaaatgatac tcagaagcaa ttttgtgaag aacagaacac     1920

tggaatatta cacgatgaga ttctgattca tgaagaaaag cagatagaag tggttgaaaa     1980

aatgaattct gagctttctc ttagttgtaa gaaagaaaaa gacatcttgc atgaaaatag     2040

tacgttgcgg gaagaaattg ccatgctaag actggagcta gacacaatga aacatcagag     2100

ccagctaaga gaaaagaaat atttggagga tattgaaagt gtgaaaaaaa ggaatgataa     2160

tcttttaaag gctctacaat tgaatgagct caccatggat gatgataccg ctgtgctcgt     2220

cattgacaac ggctctggca tgtgcaaggc cggctttgcg ggcgacgatg ccccccgggc     2280

tgtcttccct tccatcgtgg ggcgccccag gcagcagggc atgatggggg gcatgcatca     2340

gaaagagtcc tatgtgggca aggaggccca gagcaaaaga ggcatcctga ccctgaagta     2400

ccccatggaa cacggcatca tcaccaactg ggatgacatg gagaagatct ggcaccacac     2460

cttctacaac gagctgcgtg tggctcccga ggagcacccc gtcctgctga ccgaggccac     2520

cctgaaccct aaggccaacc gcgagaagat gacccagatc atgtttgaga ccttcaacac     2580

cccagccatg tacgtggcca tccaggctgt gctgtccctg tacacctctg gccgtactac     2640

tggcatcgtg atggactctg gtgacggggt cacccacact gtgcccatct atgaggggaa     2700

tgccctcccc catgccaccc tgcgcctaga cctggctggg cgggaactgc ctgactacct     2760

catgaagatc ctcaccgagc atggctatag gttcaccacc atggccgagc gggaaatcgt     2820

gcgtgacatc aaagagaagc tgtgctatgt tgccctggac ttcgagcagg agatggccac     2880

ggtggcctcc agctcctccc tagagaagag ctacgagctg cccgatggcc aggtcatcac     2940

catcggcaac gagcggttcc gctgccccga ggcgctcttc cagccttgct tcctgggcat     3000

ggaatcctgt ggcatccatg aaactacctt caactccatc atgaagtctg atgtggacat     3060

ccgcaaagac ctgtacacca acacagtgct gtctggcggc accaccatgt accctggcat     3120

ggcccacaga atgcagaagg agatcgctgc cctggcgcct agcatgatga agatcaggat     3180

cattgctcct cccaagcgca agtactccgt gtgggtcggt ggctccatcc tggcctcgct     3240

gtccaccttc cagcagatgt ggatcagcaa gcaggagtat gatgagtcag gcccctccat     3300

tgtccaccgc aaatgcttgt aggtggactc tgacttagtt gcgttacacc ctttcttgac     3360

aaaaccaaac ttctcagaaa acaacatgag attggcatgg ctttatttgt tttcttgttt     3420

cattttttgt tttgtttttt attggcttga ctcaggattt aaaaaccgga atggtgaagg     3480

tgacagcagt cggttggagg aagcttcctc caaagttcta caatgtggcc aaggactttg     3540

attgtacctt gttcttcttt tcaatagtca ttccaaatat tgtgagacgc attgtttcag     3600

gaagcccctt gccctgctaa aagccacccc acttctctct aaggagaatg gcccagtcct     3660

ctccctagtt cacacagggg aggtgatagc attgcttttg tgcaaattac ataatgcaaa     3720

attttttgaa tcttcgcctt aatacttttt aattttgttt tattttgaat gatcagcctt     3780

cgtggccccc ctcttttgta ccccaacttg gggtgtatga aggcttttgg tctccctgag     3840

agtggctgga ggcagccagg gcttacctgt actctgactt gaggagagtt ggataaaagt     3900

gcacacctta aaacaaattg aggaagcaca gtatttcagt acagtggaca gcttagcatg     3960

ttgacaactg agaataaaat gctcagttct gaactggaca atgtaagaca caacgaggaa     4020

acactggaaa t                                                          4031


<210> 1420
<211> 2563
<212> DNA
<213> Homo sapiens

<400> 1420
ctcccctgct gcagcaaggc cctcccccat ccgcacacac aggctgctgg gtaagtggca       60

agatggctcc cctgcatgtc tccggctgat cgctgccgct ccgccaatac aatagagcca      120

gccactacca gcagcctggc cctcttcctc cttctccaga gagaccaatc cagccgaact      180

cggggtttgc caaagggata aacagcactt ccagggggag aaaaaaaatc atgttatcag      240

aaagcaaaga aggtgaggag aaggaggaag tgaccatgga cacaagtgaa aacagacctg      300

aaaatgatgt tccagaacct cccatgccta ttgcagacca agtcagcaat gatgaccgcc      360

cggagggcag tgttgaagat gaggagaaga aagagagctc gctgcccaaa tcattcaaga      420

ggaagatctc cgttgtctca gctaccaagg gggtgccagc tggaaacagt gacacagagg      480

ggggccagcc tggtcggaaa cgacgctggg gagccagcac agccaccaca cagaagaaac      540

cttccatcag tatcaccact gaatcactaa agagcctcat ccccgacatc aaacccctgg      600

cggggcagga ggctgttgtg gatcttcatg ctgatgactc tcgcatctct gaggatgaga      660

cagagcgtaa tggcgatgat gggacccatg acaaggggct gaaaatatgc cggacagtca      720

ctcaggtagt acctgcagag ggccaggaga atgggcagag ggaagaagag gaagaagaga      780

aggaacctga agcagaacct cctgtacctc cccaggtgtc agtagaggtg gccttgcccc      840

cacctgcaga gcatgaagta aagaaagtga ctttaggaga taccttaact cgacgttcca      900

ttagccagca gaagtccgga gtttccatta ccattgatga cccagtccga actgcccagg      960

tgccctcccc accccggggc aagattagca acattgtcca tatctccaat ttggtccgtc     1020

ctttcacttt aggccagcta aaggagttgt tggggcgcac aggaaccttg gtggaagagg     1080

ccttctggat tgacaagatc aaatctcatt gctttgtaac gtactcaaca gtagaggaag     1140

ctgttgccac ccgcacagct ctgcacgggg tcaaatggcc ccagtccaat cccaaattcc     1200

tttgtgctga ctatgccgag caagatgagc tggattatca ccgaggcctc ttggtggacc     1260

gtccctctga aactaagaca gaggagcagg gaataccacg gcccctgcac cccccacccc     1320

cacccccggt ccagccacca cagcaccccc gggcagagca gcgggagcag gaacgggcag     1380

tgcgggaaca gtgggcagaa cgggaacggg aaatggagcg gcgggagcgg actcgatcag     1440

agcgtgaatg ggatcgggac aaagttcgag aagggccccg ttcccgatca aggtcccgtg     1500

accgccgccg caaggaacgt gcgaagtcta aagaaaagaa gagtgagaag aaagagaaag     1560

cccaggagga accacctgcc aagctgctgg atgacctttt ccgaaagacc aaggcagctc     1620

cctgcatcta ttggctccca ctgactgaca gccagatcgt tcagaaagag gcagagcggg     1680

ccgaacgggc caaggagcgg gagaagcggc gaaaggagca agaagaagaa gagcaaaagg     1740

agcgggagaa ggaagccgag cgggaacgga accgacagct ggagcgagag aaacgtcggg     1800

agcacagtcg ggagagggac agggagagag agagagaaag ggagcgggac aggggggacc     1860

gagatcggga tagggaaagg gaccgagaac gaggcaggga aagggatcgc agggacacca     1920

agcgccacag cagaagccgg agtcggagca cacctgtgcg ggaccggggt gggcgccgct     1980

agctgggaaa acactagagc tgcaggtacc agccactcgg ccccaggggg ttatggccac     2040

agagggatag gcacagtctc caccaccctg gagccaaggg tctttcacat cacctatccc     2100

tacatacata ccaaatggaa aagtggccat ccttttcccc ccaaacacac ccccttaacc     2160

tatctcttgg gacttagccc gaccctccct ctcatttccc attaagtctg agaggcaaga     2220

gctaggttag gcaaggaggt ggttggccag agatggggaa cagccaggtg ccccagtcct     2280

ctgatttttc ctccatcctg cttaccacct ccctgggtac ttacagcctt ctcttgggaa     2340

cagccggggc caggactggg tcacctatga gctgaatcag catctcctcc tgagtcccag     2400

ggcccctgca gttcccagtc tcttctgtcc tgcagccctt gcctctttcc cacaggttcc     2460

actttatatc caccttttcc ttttgttcaa tttttatttt tatttttttt attattaaat     2520

gatgtggtct atggaaaaaa aaataaaaat ctgacttagt ttt                       2563


<210> 1421
<211> 1348
<212> DNA
<213> Homo sapiens

<400> 1421
ttttctgccc gtggacgccg ctgaagaagc atcgttaaag tctctcttca ccttgccgtc       60

atgtctaagt cagcgtctcc aaaagagccc gaacagctga ggaagctctt cattggaggg      120

ttgagctttg aaacaactga tgagagcctg aggagccatt ttgagcaatg gggaacgctc      180

acagactgtg tggtaatgag agatccaaac accaagcgct ccaggggctt tgggtttgtc      240

acatatgcca ctgtggagga ggtggatgca gctatgaata caacgccaca caaggtggat      300

ggaagagttg tggaaccaaa gagagctgtc tccagagaag attctcaaag accaggtgcc      360

cacttaactg tgaaaaagat atttgttggt ggcattaaag aagacactga agaacatcac      420

ctaagagatt attttgaaca gtatggaaaa attgaagtaa ttgaaatcat gactgaccga      480

ggcagtggca agaaaagggg ctttgccttt gtaacctttg acgaccatga ctccgtggat      540

aagattgtca ttcagaaata ccatactgtg aagggccaca actgtgaagt tagaaaagcc      600

ctgccaaagc aagagatggc tagtgcttca tccagccaaa gaggtcgaag gggttctgga      660

aactttggtg gtggtcgtgg agatggtttc ggtgggaatg acaactttgg tcgtggagga      720

aacttcagtg gtcgtggtgg ctttggtggc agctgtggtg gtggtggata tggtggcagt      780

ggggatggct ataatggatt tggtaatgat ggaagcaatt ttggaggtgg tggaagctac      840

aatgattttg gcaattacaa caatcagtct tcaaattttg gacccatgaa gggaggaaat      900

tttggaggca gaagctctgg cccctatggc ggtggaggcc aatactttgc aaaaccacaa      960

aaccaaggtg gctatggcgt ttccagcagc agcagtagct atggcagtgg cagaagattt     1020

taattaggaa acaaagctta gcaggagagg agagccagag aagtgacagg gaagctacag     1080

gttacaacag atttgtgaac tcagccaagc acagtggtgg cagggcctag ctgctacaaa     1140

gaagacatgt tttagacaaa tactcatgtg tatgggcaaa aaactcgagg actgtatttg     1200

tgactaattg tataacaggt tattttagtt tctgttctgt ggaaagtgta aagcattcca     1260

acaaagtgtt ttaatgtaga tttttttttt tgcacccatg ctgttgattg ctaaatgtaa     1320

tagtctgatt gtgacgctga ataaatgt                                        1348


<210> 1422
<211> 4335
<212> DNA
<213> Homo sapiens

<400> 1422
gatacttgct gtaagtagca aaaagatggg aaggaaagtc tacagaccaa atcatatctg       60

aatctcccca ttctccctct ccacaaatat tggtttagga attctccgaa gtttgaaggt      120

tatgaatggt tatcactcaa ggattcagaa ctaagcagag gaaagaaatt cctaagggaa      180

cactgctcag aaagtactgc agcatgtctt caaatgcctg aggatcaagt tggaaaacta      240

gaagcaacag aaaacacaat aagccccagg cgtgagtcac tggagagcgc gacgggagga      300

aggggcgccc tgagtccaca gccctggggg aggtcggagg gtctgaaagc gagaagtccg      360

tgagtagaag cgcaatggcg gcggccgcgg cggagcagca acagttctac ctgctcctgg      420

gaaacctgct cagccccgac aatgtggtcc ggaaacaggc agaggaaacc tatgagaata      480

tcccaggcca gtcaaagatc acattcctct tacaagccat cagaaataca acagctgctg      540

aagaggctag acaaatggcc gccgttctcc taagacgtct cttgtcctct gcatttgatg      600

aagtctatcc agcacttccc tctgatgttc agactgccat caagagtgag ctactcatga      660

ttattcagat ggaaacacaa tctagcatga ggaaaaaagt ttgtgatatt gcggcagaac      720

tggccaggaa tttaatagat gaggatggca ataaccagtg gcccgaaggt ttgaagttcc      780

tttttgattc agtcagctct caaaatgtgg gactgcggga agctgccctt cacattttct      840

ggaactttcc tggaattttt gggaaccagc aacaacacta tttagatgtc atcaaacgaa      900

tgttagttca gtgtatgcaa gatcaggaac acccgtcgat caggacgtta tctgctagag      960

ctacagctgc atttatactt gcaaatgagc ataatgttgc tctgttcaaa cattttgcag     1020

acttgctacc gggattccta caggcggtaa atgactcgtg ctaccagaat gatgattctg     1080

tcctaaaatc cctcgttgag attgcagata ctgttccaaa gtatttgcgt cctcacttgg     1140

aagcaactct acagctaagt ctaaagttgt gtggagacac tagcctcaac aatatgcaac     1200

gccagcttgc ccttgaagtg atcgtcaccc tctctgagac tgcagctgct atgttaagaa     1260

aacataccaa tattgttgca cagactattc ctcagatgtt agcaatgatg gttgatttgg     1320

aagaagatga ggactgggca aatgcagatg aactagaaga tgatgatttt gacagcaatg     1380

cagttgcagg cgagagtgct ctagatcgaa tggcttgcgg acttggtgga aagctcgttc     1440

tgccgatgat caaggaacac attatgcaaa tgcttcaaaa tcctgactgg aaataccggc     1500

atgcaggatt gatggcctta tctgccattg gtgaagggtg ccaccagcaa atggaaggaa     1560

ttctaaatga gatcgtaaat tttgttttac tttttctcca ggatcctcat ccaagagtaa     1620

ggtatgcagc ctgtaatgcc gtgggacaga tggctacaga ttttgcacct ggtttccaaa     1680

agaaatttca tgagaaggtg attgcagctc tgctgcagac catggaagac caaggcaatc     1740

aacgtgtgca ggcccatgca gctgctgccc tcattaactt tactgaagac tgtcccaagt     1800

cactacttat tccatacttg gataatttgg tgaaacatct gcattccatt atggtactga     1860

agcttcaaga gctgattcag aaaggcacca agttagtttt ggaacaagtt gtgacatcca     1920

ttgcatcagt tgccgatact gcagaagaaa aatttgtccc ctactatgat ttatttatgc     1980

catcactgaa gcacatcgtt gagaatgcgg ttcaaaaaga actgagactt ctgagaggaa     2040

aaactattga atgcattagc ctcattggtc tggctgttgg gaaggaaaaa ttcatgcagg     2100

atgcatcaga tgtgatgcag cttttgttaa agacccagac agacttcaat gatatggaag     2160

atgatgatcc tcagatctct tacatgatct cagcatgggc cagaatgtgc aaaatccttg     2220

gaaaagaatt tcagcaatac cttccagtgg ttatggggcc tttaatgaag acggcttcaa     2280

ttaagcccga agtagccctt ttagataccc aagacatgga gaatatgagt gatgatgatg     2340

gttgggaatt tgtgaacctt ggagatcagc aaagctttgg tattaaaact gcaggactag     2400

aagaaaaatc aactgcttgc cagatgttgg tttgctatgc taaggagtta aaggaaggct     2460

ttgtggagta caccgaacag gttgtcaaac tgatggtccc tttactgaaa ttttatttcc     2520

acgatggtgt tcgagtggca gcagcggaat ccatgcctct tctcctggag tgtgcaagag     2580

tccgtggtcc tgagtatctc acacagatgt ggcattttat gtgtgatgct ctaattaagg     2640

ccattggtac agaaccagat tcagacgtcc tctcagaaat aatgcattct tttgcaaagt     2700

gcattgaagt aatgggagat ggatgcctta ataatgaaca ctttgaagaa ctgggaggta     2760

tattgaaagc aaagcttgaa gaacatttta aaaatcaaga attacgacaa gttaaaagac     2820

aagatgaaga ctatgatgaa caggtcgaag agtcactaca agatgaggat gataatgatg     2880

tttatattct gaccaaagtg tcagatattt tacactcaat attcagtagc tacaaagaaa     2940

aggtgttacc atggtttgaa cagctgcttc cattaattgt caacctcatt tgtccacata     3000

gaccatggcc agacagacaa tggggattat gcatctttga tgatgtcata gaacactgta     3060

gtccagcctc atttaaatac gcagaatatt tcttaagacc aatgctccaa tatgtatgtg     3120

acaacagccc agaagtcagg caagcagctg catatggcct gggagtcatg gcacagtacg     3180

gtggagataa ttatcgccct ttttgtacag aagcacttcc cctgctggta agagttattc     3240

agtctgcgga ttctaagacc aaagaaaatg tcaatgctac agagaactgc atctcagcag     3300

tagggaaaat catgaagttc aagcctgact gtgtaaacgt tgaagaggtc cttccacact     3360

ggttgtcttg gcttccacta catgaagata aagaagaagc tgttcagact ttcaattatc     3420

tgtgtgacct gattgaaagt aatcatccaa ttgttcttgg cccaaacaat accaatctgc     3480

ccaaaatatt tagtataatt gcggaaggag aaatgcacga ggcaattaaa catgaagatc     3540

cttgtgccaa acgtctggcc aatgtcgttc gccaagtaca gacttctgga ggactgtgga     3600

ctgagtgcat agcacagctc agtcctgagc agcaggccgc cattcaggag ctcctgaact     3660

ctgcgtgaag ggccttaatg tcacccacca gaaaactaac tccaaataaa cgcttaccct     3720

ttcctttagg tttctttgtt ttgtttttga gcaaaagaga tcggtagtgt tgtgtgtagg     3780

ccattcttct ggagagccac aagcaggaag agcagcgctg tgttgcagaa tggagtttcc     3840

atggatttct accagaccac tgaaggagtt cctggaagcc ctgcggtagc tagcactgaa     3900

gactattttt ctattggtat aacccgccca cctgaagggg aaagggaaat caaattaatt     3960

tttctcgtta gacataagga aatttaagga aaaacagctt taagaacagt tactcagcgt     4020

agatgtgtgt tcacacaaat tgctctgcat tcagtgttca ttgtgaattg ggagtgtgag     4080

tctttctgta gggtagaaag aagcctccta cccagcaaac cagtagaccc aaaagttgaa     4140

aaaaactgat gacagacaac aagcatgaag atggcatatt tgatgtcact ttggttcttt     4200

ttcccagaag gcttatacag tgactcagtc gggaagcttt ccagcttcca gcccttgaat     4260

gtgaagtgtc attggcatgt ctggcagtag tctctcattc actcctcaat aaacaacatt     4320

gaatacaaaa gaggc                                                      4335


<210> 1423
<211> 3395
<212> DNA
<213> Homo sapiens

<400> 1423
cttctcttgt gtaatcagct gcctatttgg aaattgggca gggtttgcga ctggatgcta       60

atgtcactga ctagttttca gcctaccatc cagaagtaac atgttcccag ctttggaaac      120

gcacctaaag cagactattc ctgatcctta tgaagacttt atgtaccgtc acctccaata      180

ttatggctac tttaaagctc agagaggcag tttaccaaac tctgctacgc atcagcatgt      240

tcggaagaat aaccctcaat gcctgttgaa tggctctctt ggggaaaaag atgatttgat      300

accagacacc ctgcaaaagg agaagcttct atggcctatc agtttatctt cagctgtgca      360

cagacagata gaagccatca acagagactt tcactcttgc ctgggctgga tgcagtggcg      420

cggcctcagc tcactgcaac ctccacctcc cagattcaag gattctcctg cctcagcttt      480

ccgagtagct gggattacag attcacatat gctgagttta ccacatctta ggagcagaca      540

gcttctttat gatgagttgg atgaagtaaa cccacgtctt cgagaacccc aagagctctt      600

ttccattttg tctaccaaga ggccactgca ggctccaaga tggccaattg aatgtgaggt      660

catcaaggaa aacatccatc atattgagtg ggctccacct caaccagaat atttctatca      720

gcctaaagga aatgaaaagg taccagagat tgtaggagag aaaaaaggaa cagttgtcta      780

tcaattagat tcagtgccta tagaaggttc ctattttacc agttccagag tgggaggcaa      840

acgaggaatt gtcaaggaac ttgctgtcac gttgcaagga ccagaagata atactctact      900

gtttgaatca aggtttgaga gtgggaatct gcaaaaagct gtcagagtag acacctatga      960

gtatgaactc accttgcgaa ctgacctcta cactaacaaa cacactcagt ggttttattt     1020

tcgtgttcag aacaccagaa aagatgctac ctatcgcttc accattgtca acttgctaaa     1080

acccaagagt ctttatactg tagggatgaa gccactcttg tactcccaat tggatgccaa     1140

cacccgcaat attggctgga ggagagaagg aaatgaaatc aagtactaca agaacaacac     1200

ggatgatggg cagcagccct tctactgtct cacgtggacc attcagtttc catatgacca     1260

ggacacttgc ttctttgcac acttctaccc atatacatac actgatttgc aatgctacct     1320

cctgtcagtg gcaaacaacc ctatccagtc tcagttctgc aagctccaaa ctttatgcag     1380

gagcctagca ggaaataccg tttacttgct caccatcacc aacccatccc agacccctca     1440

agaggcagct gcaaagaaag ctgtggtctt gagtgccaga gttcaccctg gagaaagtaa     1500

tggctcctgg gttatgaaag gctttttgga cttcatcctt agcaactccc cagatgccca     1560

gctcctcaga gatatttttg tcttcaaggt gcttcccatg ttaaatccag atggtgtgat     1620

tgtggggaat tatcggtgtt ccttggccgg aagggatttg aacaggcatt ataaaaccat     1680

tctgaaggag tctttccctt gtatttggta caccaggaac atgatcaaaa gacttcttga     1740

agaaagagag gttctgttgt attgtgattt ccatggccac agtcgtaaga ataatatctt     1800

cctgtatggc tgtaataaca acaatcgcaa atactggctt catgaacgag tctttccttt     1860

aatgttatgc aaaaatgcac cagataagtt ctcttttcac agttgtaatt ttaaggtcca     1920

aaaatgcaaa gaaggaacag gacgagttgt tatgtggcgg atgggaatcc taaacagcta     1980

caccatggag tctacctttg gcgggtccac cctgggtaat aaaagagaca cccactttac     2040

catcgaagat ctgaagtcct taggttatca tgtctgtgac acccttctgg acttttgtga     2100

tcctgaccaa atgaagttca ctcagtgtct agcagagctt aaggagcttt tacgacagga     2160

aatccacaag aaattccatg aacttggaca agatgtagat ttagaaggaa gttggagtga     2220

catctctttg tctgacattg aatccagaaa cagcaccagt ggctctgaca gttctctctc     2280

agatggtctt cctgttcacc tagcaaacat agcagatgag ctgactcaga aaaagaagat     2340

gtttaagaag aaaaaaaaga agtcacttca gactaggaaa cagcgaaatg agcagtatca     2400

gaaaaaaaat ttgatgcaga agttaaagtt aacagaagat acctcagaaa aggcaggatt     2460

tgcttctact ctgcaaaagc agccaacctt tttcaaaaac tcagagaatt ccagtttttt     2520

accaatgaaa aatgaaaacc caaggttaaa tgagacaaat ttaaatagaa gagacaaaga     2580

cacccccctg gacccatcaa tggccaccct gattctgcct aagaataaag ggagaatgca     2640

gaataagaag ccaggcttta cagtatcatg ctctccaaag agaaccataa actccagcca     2700

agagccagct ccaggtatga agccaaactg gcctaggagc agatatcctg ccacaaagag     2760

aggctgtgct gccatggcgg catacccatc cttgcacata tacacatacc cgtaggtgag     2820

cctgggctgt gccacacaag cacttcatcg ggggttttga gattagacac attttataat     2880

gggggagatg tatgactggg aactgcattt acttgtggta tactgtgttg tgcactcatg     2940

cactgacctt acactttgta cttacactgt gggcatgtgg tcaagatgca tacctcatga     3000

attcaactat tttttcataa aatgaaattt tattatgatg tgtaaaaatg ctttatcaga     3060

aactgaagtg tgttctcatg gcacacttca tggcagcaca gatatacctc attttaacca     3120

atagatattc tctctaaaat tatgtgcaaa tcaattttta aaaatcaaaa tctatgttaa     3180

acacattttg gcagtgtgct ataataaaaa aaagtgttgt gtcaaagctt tctagtgacg     3240

gtcagtccta ctgctgtatg tcaggtttgc tcacaatgag gtattcccac atagaaataa     3300

caatgcatgt attacccaga atttaatgtt gcgtacctta tgttcaatga ggttttgtaa     3360

tttttttagg ctgatgatta aaattctttc tctct                                3395


<210> 1424
<211> 6128
<212> DNA
<213> Homo sapiens

<400> 1424
agtctagtgg gataccaggc cctgagagac ccctacgatc ccaggacact gatgtggggt       60

aactaacacc cactggaagt ctacgctgag ttcacaggct atagtcagag gttccggttg      120

agatcaagtt gggagacaca cccttgttca ttctccttga gaagcagcta ttatcaacag      180

aacattgaca gaacctgtgt ttggggaaag gactgatggc tttgagtcta ggttggaaag      240

cacacaggaa ccactgtggt ctcctcttgc aggctctgcg aagcagtggt cttctcttgt      300

ttccctgtgg ccagtgtccc tggagaggag ctggaagctt tttggaccct gagataaagg      360

ctttcctgga ggagaacact gaagtcacca gcagtggtag cctcacccct gaaatccagt      420

tgcggctttt gacccccaga tgcaaattct ggtgggagag agctgacctg tggccccaca      480

gtgatcctta ctgggcaatc tactggccag gaggccaagc cctgtctagg tatcttttgg      540

ataatcctga tgttgtcaga ggaaaatctg tattagatct tgggagtgga tgtggagcta      600

cagctattgc tgctaagatg agtggggcat caaggatctt ggccaatgac atagacccta      660

ttgcaggaat ggctattaca ctaaattgtg aattgaacag actgaatcct tttcctattt      720

taatccaaaa cattttgaat ttggaacaag ataagtggga ccttgttgtt cttggcgata      780

tgttttatga tgaagacctt gcagatagtc ttcatcagtg gctgaagaag tgcttctgga      840

cctatagaac tcgagtactg attggtgacc ctgggcggcc ccagttcagt ggacacagca      900

ttcagcatca cctgcacaaa gtggtagaat attcactttt ggagtctact aggcaggaaa      960

acagtggact gacaacaagc acagtgtggg gttttcagcc ttgagttgtc aaagtgcttc     1020

caagtatgaa tatagtaatg tttggatctg actctaaaag ttttctctat aggagatact     1080

ctccagttta atgaatgtaa ttcttgttaa atggaaaatc ttgtttttaa aatatgaagg     1140

tttagagttt tgtttacttt tgtcatgtaa ctggttctgt atttctatgc atgccaatta     1200

tacacatctc tatctgcatt tttttttcta ttttaaccgc tgaaggaata tgattataca     1260

atgccatact caatggtggc agcatttaat ttaagtaatg gagaagaatt aaacattgta     1320

gctggatctg tttctgtagt cgaggacaac tgtgatgtaa ctttgaatta aacaaacaaa     1380

acaaaacaga agaagactat atatatattt tttctttttt tagagacagt ctcactttgc     1440

tcccaggctg gaatgcagtg gctattcaga ggcttaatca ttgggcactg cagccttgaa     1500

ctctgggctt tttttttttt ttgagatgga gtctcagctc tgtcgtccag gctggagtgc     1560

agtgactcat gtctcggctc actgtagcct ccacctcccc caatcaagcg attgtcctgt     1620

ctcagcctcc agagtagctg ggattttagg tgtgcaccac catgcctggc taatttttgt     1680

atttttagta gagacggggt tttgccatgt tggccaggcc ggtctcaaac tcctgacctc     1740

aggtgatcca cccgccttgg cctcccaaag tgctaggatt acaggtgtga gccaccacgc     1800

cagcctgacg atgtttttta cttctatcac ttccttttga ttttttctta tagcttctat     1860

ctctgcttac gtcacccatc attcttgcgt gttgtatgct tttcgcatta gagccctttg     1920

catgttaatc agttatttta aatttatgat ctggtaattc taaaatgtct gccataactg     1980

agtctggttc tgatgcttgt tttcttttca gactgttttt ttgtctttta gcatgccttg     2040

taattttttg ttgatagcta gacatgatgt attgcataaa taaacaagta aactaaggta     2100

gcatgaggtt ttaaaatctg ggtagggcta ctgtttgctg tagagtagat attacaggct     2160

aaattttcct ctagtgtcct ggctattgtc tcctctgtta tctttgagtt tccctagaga     2220

ttccttctta tatagagtct gaagcttgca gtttttttca cctgtaattc cctgttatta     2280

tacagtagcc taactgatgt gataaggtat gggagaaggt atgttctata gtcctgtgat     2340

taagtctcag tcagttaagt cagcctgtgc ccctgctgtg accttcacaa gtgctttcag     2400

cttttctttt gtcactttgg tgagacagga aggctagagg cagctggagt tgggtgcttc     2460

ctttccccca ggtcaacgag gctctggtaa aatagtttcc cttgagaact ggcttttgtt     2520

aaggagaact gaacacttgg gcatatttca aaatggttac tttccctatc ctcataccag     2580

aagaggggat ttttctctga tcctcaccct gagaacctgg taggtatcct ggaggtaaaa     2640

ctatgaaagt gtggtgtctc ccctaggagt gggccccctg gagtttgttt gttttaattt     2700

aacaaagttt aattgagcaa agaacaatct gtgaattggg cagctcccaa aagcagaata     2760

ggttcagagt gactgcaggg ttgccacacc tggttagata acgtttatgg acagattcct     2820

agagcttttg attctttttt tttttttttt gaggcagagt ttcactctta ttgcccaggc     2880

tggagtgcaa tggcgtgatc ttggctcact gcaacctcca cctcctgggt taaagtgatt     2940

ctcctgcctc agcctcctga gtagctggga ttacaggtat acaccaccaa acccagctgg     3000

gattacaggc atgcaccacc atgcccagct aatttttgta tttttagtaa agacagggct     3060

tcgccatgtt ggccaggctg gtctcgaact cctgacctca ggtgatccac ctgcctcagc     3120

ctccccaagt gctgggatta cacgtgtgag ccactgtgcc aggctggagc ttttgattct     3180

taagtccatc cacatggagc ctccagcaac tcaggaatta cagcataaat gttcctattg     3240

gtactggctc cagcaacagg cttctgctcc ctgtaagcta tggttctttg tatttgcgtt     3300

tctaatttgt gaggcattct ctctttaacc ttaattctct aatggatcta agtgttgttg     3360

acttttcagt ttattgagct tttttcttat tgtgaggatg ggaatgatga cttccaatct     3420

ctttatatta gaaaatataa atcagactag agactggaaa tttttgttgt tgttgttggg     3480

tgttttgttt tgtttgtttt tagacaggtc ttgctctctc atccaggctg gagttcagca     3540

atgcgaccgt gctcactgca gcctcgactt tctaggctca ggtaatcctc ccacttcagc     3600

ctccttagta gctaggactg taggcatgca ccaccatgat gcctggctag tttttttatt     3660

ttgtattttt tgtagacatg gagtcttgct acattggcca ggctgggtat tactgggtat     3720

ttctttcttt cctcctttat ttctttccat atttacttat tcaatgaata tttgagtgct     3780

tattatatac caggcactgt tctaggcact ggggatatgg ggatacagca atgaaaaaaa     3840

aagataaata ctttgtcctt atgaaatttg tattctagag tagggagaca taatgaacaa     3900

atgaaaacag gcatcagatg gtgataggta gtaaggagaa aaagaagtaa gggtaatagg     3960

gaatactggg tactggatgg ggtacagata ttttaaacag agtggtgaga aatagttaat     4020

acagctagca acataaaaaa ggagaaatat caaactgcaa actgttttag gaagataaat     4080

ccttcataga cccaaagaag ctcacaattt agatgtcgaa actagtttct gcaaaaaggg     4140

gaaaatgtga ttgacttggt taaatattca gtattaaatt ttattgaatt tgtctttaga     4200

aaaatttcat agttagaaca ggccttaccc attttgcaca tatatacata tgcaccacct     4260

ttgcagtggc aacatatata tccacactat aaacatacca catttataaa tcttgtaagg     4320

acaagaaatg gagttgaata agtacccccc aacatataca agaaagttag catacttacc     4380

ccgtttttca ctacatcaga ggcaaaataa gaaatctttt aagaaaatct caagactggc     4440

tcatggcaaa atgaatatgc taaatttggg ggttggttta agcgtggtat gtgtcaggta     4500

attttgtgat taccaaaaag ttttcacttg aaaactaaga cctttgctgt ttatttcaca     4560

atgtgaaatc aataaacctg aggatacaag tctctgtagt gatattctgt atttactcat     4620

ttttacacat ttttgaatgc aattttgcta aggaaggaaa gcttacagat gcataaaatg     4680

taactgggaa gagtagccat aaaaatcaat gaatggatgt ggctgggcaa gagcctctgt     4740

aatactaata cgctgaatgg ctaataagtc acttcatttc ggtgaaacaa atacctaaat     4800

tctttgaaga attaacaggc ttgatgttca ggtctgcttt tggcaaatgg gcatttaaat     4860

actccaagaa ggtaagagcc agaaaatagg aaggtaacta tgcttttaga aatatgttta     4920

cttagattct cccaaggttt atacttacag gtaaacttag aacaatagct caaataccta     4980

cataggagaa ggaaatctca agggaaaaca gttaatttta aagttattta agaaacagaa     5040

tccaacacca tagatcagag ttcatgctag gattatcatt tcaaaaataa tgactcatcc     5100

aacagatata gaataatagc actttaaaga tgtttaagag taaagcacaa accatgtata     5160

taccaagact tagctaattc tctgagagtt ataacttaag acaataaaat aattaaaaat     5220

agtgttaaca ttaagtagaa tgcaaatctc tatagatggt ttcctgggaa agtagttttg     5280

ataagctttc ctagcattga tcatcttcaa aaaagcatca ataaacagtc catgtcactt     5340

gctttagttt gtttgggcct actaattgct ccaacacttc tcgggaatga tctataaaag     5400

aaaacaatga caatatatta attgacaata aaaaatgttt aatgtttcct catgtctaac     5460

tggaggtgat gttaattatt atacagttat ttaaaggatt aaaggaggtg atctataaag     5520

cacaatatac aactaactca ctaataatta attaatggta gccctcacta ttattaggtg     5580

tagtgcacct atcatggtat tacttgttta aaaaaaaaaa acaggcattt gttgttttct     5640

ctgtaatttc atcataattc caccaaccag agtaatggtc taatttcacc attaacctgt     5700

gttaatggtt aataactttt ttcaggatct tagccggaaa tagatgattc actaaagtgg     5760

ggtgactgaa cagcatttaa tgaagggaat atttaccaaa aaagtaggat taaagaaagc     5820

caataggtac ggtaaaccac cttgggaagc tgcaacacac ccaaagggtt aaaggaggta     5880

gtagtcaccg aacgtgacaa gttgacctgt agctgaacat ttttccatgt ctgtataata     5940

ctactataaa gcatgatttt aaatagataa ccattatata aatacactgt aatttaacca     6000

atctatatta ttggacattt agatgttttc agtttttcac aatgtacagt cgtgattttg     6060

atatggtttc catcctagtt ttaggatgtc ttttaaaaat ctgaattaaa gcaaaaatac     6120

tgataaaa                                                              6128


<210> 1425
<211> 5603
<212> DNA
<213> Homo sapiens

<400> 1425
aacgcagctg cggcggctgc gggtctcgtg ggggcggagc ggtcgccgct gccgccgcag       60

ctcgggtcgg gatttgaaag attagaaact tcgggtggag agggcggcgg cgttgaatgt      120

gtggcggaag cgctgggggt cacggctccg cgcgccgccg gacagccggc ggcgtctcca      180

cagcatgaat tacccgggcc gcgggtcccc acggagcccc gagcataacg gccgaggcgg      240

cggcggcggc gcctgggagc tgggctcaga cgcgaggcca gcgttcggcg gcggcgtctg      300

ctgcttcgag cacctgcccg gcggggaccc ggacgacggc gacgtgcccc tggccctgct      360

gcgcggggaa cccgggctgc atttggcgcc gggcaccgac gaccacaacc accacctcgc      420

gctggacccc tgcctcagtg acgagaacta tgacttcagc tccgccgagt cgggctcctc      480

gctgcgctac tacagcgagg gtgagagcgg cggcggcggc agctccttgt cgctgcaccc      540

gccgcagcag cctccgctgg tcccgacgaa ctcggggggc ggcggcgcga caggagggtc      600

ccccggggaa aggaaacgta cccggcttgg cggcccggcg gcccggcacc gctatgaggt      660

agtgacggag ctgggcccgg aggaggtacg ctggttctac aaggaggaca agaagacctg      720

gaagcccttc atcggctacg actcgctccg catcgagctc gccttccgga ccctgctgca      780

gaccacgggt gcccggcccc agggcgggga ccgggacggc gaccatgtgt gctcccccac      840

gggcccagcc tccagttccg gagaagatga cgatgaggac cgcgcctgcg gcttctgcca      900

gagtacgacg gggcacgagc cggagatggt ggagcttgtg aacatcgagc ctgtgtgcgt      960

gcggggcggc ctctacgagg tggatgtgac ccaaggagag tgctacccgg tgtactggaa     1020

ccaggctgat aaaataccag taatgcgtgg acagtggttt attgacggca cttggcagcc     1080

tctagaagag gaagaaagta atttaattga gcaagaacat ctcaattgtt ttaggggcca     1140

gcagatgcag gaaaatttcg atattgaagt gtcaaaatcc atagatggaa aagatgctgt     1200

tcatagtttc aagttgagtc gaaaccatgt ggactggcac agtgtggatg aagtatatct     1260

ttatagtgat gcaacaacat ctaaaattgc aagaacagtt acccaaaaac tgggattttc     1320

taaagcatca agtagtggta ccagacttca tagaggttat gtagaagaag ccacattaga     1380

agacaagcca tcacagacta cccatattgt atttgttgtg catggcattg ggcagaaaat     1440

ggaccaagga agaattatca aaaatacagc tatgatgaga gaagctgcaa gaaaaataga     1500

agaaaggcat ttttccaacc atgcaacaca tgttgaattt ctgcctgttg agtggcggtc     1560

aaaacttact cttgatggag acactgttga ttccattact cctgacaaag tacgaggttt     1620

aagggatatg ctgaacagca gtgcaatgga cataatgtat tatactagtc cactttatag     1680

agatgaacta gttaaaggcc ttcagcaaga gctgaatcga ttgtattccc ttttctgttc     1740

tcggaatcca gactttgaag aaaaaggggg taaagtctca atagtatcac attccttggg     1800

atgtgtaatt acttatgaca taatgactgg ctggaatcca gttcggctgt atgaacagtt     1860

gctgcaaaag gaagaagagt tgcctgatga acgatggatg agctatgaag aacgacatct     1920

tcttgatgaa ctctatataa ctaaacgacg gctgaaggaa atagaagaac ggcttcacgg     1980

attgaaagca tcatctatga cacaaacacc tgccttaaaa tttaaggttg agaatttctt     2040

ctgtatggga tccccattag cagttttctt ggcgttgcgt ggcatccgcc caggaaatac     2100

tggaagtcaa gaccatattt tgcctagaga gatttgtaac cggttactaa atatttttca     2160

tcctacagat ccagtggctt atagattaga accattaata ctgaaacact acagcaacat     2220

ttcacctgtc cagatccact ggtacaatac ttcaaatcct ttaccttatg aacatatgaa     2280

gccaagcttt ctcaacccag ctaaagaacc tacctcagtt tcagagaatg aaggcatttc     2340

aaccatacca agccctgtga cctcaccagt tttgtcccgc cgacactatg gagaatctat     2400

aacaaatata ggcaaagcaa gcatattagg ggctgctagc attggaaagg gacttggagg     2460

aatgttgttc tcaagatttg gacgttcatc tacaacacag tcatctgaaa catcaaaaga     2520

ctcaatggaa gatgagaaga agccagttgc ctcaccttct gctaccaccg tagggacaca     2580

gacccttcca catagcagtt ctggcttcct cgattctgca ttggagttgg atcacaggat     2640

tgattttgaa ctcagagaag gccttgtgga gagccgctat tggtcagctg tcacgtcgca     2700

tactgcctat tggtcatcct tggatgttgc cctttttctt ttaaccttca tgtataaaca     2760

tgagcacgat gatgatgcaa aacccaattt agatccaatc tgaactctct tgaaggacat     2820

gaatggccta aaactgattt tttttttttc cgttaaaatg tgtgtgtcaa gatacggaga     2880

tttcagggtt aaagtatatt tcagttttct ttagggcaac atatatttga atttaaaagc     2940

actttattta aaaaaaaaag aagttttcag ttctgaagaa gtcatttaca gtttgcatca     3000

ttttaattat gagtctgaca aaaccttctc cagagaatca agcaagacct ggatgtgaag     3060

aaggtttggg taaactgcat gtaaaggcta caaatcacaa tctgattcct cccaaatata     3120

aaggcatatg gaacataatg tattaaccaa agtatgttat aaatcaaaaa tggtcaaggt     3180

tcagcatatt ctatatgaag atcacaaggt ggtatcgttt tagatttcta tgaaggcttt     3240

catttgtaca tccctttgaa aaaatataac agatttaaaa tgttttgaat ttaacttgtt     3300

tagaaaaact aatgcttaaa acaatatttg aactactgta tttataattt attacctcta     3360

attgctttat ttcagtgtat gagacattac tgttttaatg tttgctttga acataattta     3420

agaaccagat ttattttcta tagtgataaa cccttttttc tcagaactcc atctttgtac     3480

tcttcagatg aatatataga cactgtggca tacatttttt ttcattaaaa acttatggct     3540

tcatacaaca ctagttcaat tttttaaata aactttttat tatgttacat gtacttcaga     3600

gaaagctaaa gtttctctaa acttgacacg gagtactcca taatgggtac atttcattag     3660

ctttattaga aaactagtaa atgcttttga ataggtagta tgacagctat tttaaatgta     3720

taaacatttg tgtgccaaac aacatatatg aagggatgtg atgccactaa ctagtgcaca     3780

ttgtttctca atgtgccatt gagacacaag gcacagtaag tcaggattct gaggcattgg     3840

aagggttttc ttcagctgta attgtttcca cagtgctttt catctgaggg gctcaaagtt     3900

taagagtgca ttcaataacc catgtactag cttcttgagg taagtaaata aatcttgttc     3960

tcatgttaca tgttaataca ccaaggcacc aaaacattta aagtgccatg aattagatta     4020

catcagaaat cagaaaagct tggattgagc tagtcaccgt ggttcacgcc tgtaatccca     4080

acacttcggg aggccaagat gggaggatct cttgagccca ggatttcaag accagcttgg     4140

gcaacatagt gagaccctct tctctgcaaa aactgacaaa aattagccac ttgtagtggt     4200

gtacacctgt agtcccagct actcaagagg ctgaggtggg aggatcaccc gagcccagaa     4260

gttcaaagct gcagtgagct ctgatcacac caatgcactc cagcctgggt gacagagcca     4320

gaccctgtct ctaaaaaaca aaaaagaaaa gcttgggttg aagccaggcc atattctttt     4380

atatgctgtt caatgacttg attcacatgt gaccttttag tagtttgcaa acaataataa     4440

cagaagttgc aattcataat tcagagaaat gaccatgaag ccggtgtttc cctgcttgat     4500

ttctatgttc ttggattctc acacaaaaga ggagttacct agaggggatc agtagccatc     4560

cctgttgcac acaaccctca cttctgagtg gtttccacta ggttccactt aaggtgctgt     4620

cttttcttaa cttgcaagga attgcttagc ttcccaataa tcattgtcaa actgggagca     4680

aagttggtca gctgtatctc tcacctcctc ctttcttcat aagatagtag aatctgtggc     4740

ttacttgtag gttttactta gtgcttcagt actgttggct gttttggcct tttgctgaat     4800

ttgcacaaca acataaagca cttcttttta atgtttaaaa aaaattccaa ggctccatga     4860

ccaagtatgt gactcactaa gaaacccttg ctataaaagg cttttgatga aatcttagca     4920

aagctaaatt atctctaact tagagattcc tatgaactca ggtcattttc atagcctgtt     4980

tattttgtag gtctaattta gttctcagga aaattaaact catgctatat gactgtatcg     5040

ttaaaggtac ttgagcgtat gttgctgtag gtggtatgac actcaaatgc ataagaactt     5100

gaagggattt attcttaacc actagaatat gaagagccct ttttacctga gaagagtgaa     5160

attatgtcag accttttaat ttgatatcac tgagtaaaag gtatgttcct atagccatag     5220

gaatatgtct gcttcctttt tttcatgttg agaaaacagt caaatttaac catttggagt     5280

ttatttgaat tcttggaaag agcaatattc aaaacctttt caaaaataag atattctgga     5340

ctactggatg gatgttttgt tttcagttca tttttcatca gtagagatgg tgatttcggt     5400

tttgtagtat ccttgtttct atgtctgtgc atgttaacat tggatgtatt tgtatatact     5460

taattaatat acagactgtg tgtcattctg gcttgattag aagctaagtc agttactgag     5520

taacattttg caactttatt ccagcaagta ctaaatcggc caaaaaaagt tttgtttttg     5580

ataccattaa aattttattc tct                                             5603


<210> 1426
<211> 1883
<212> DNA
<213> Homo sapiens

<400> 1426
aagatggttg attcacagaa cccaggctgg acgggacttg tggcgagcag tccagcacag       60

cctcacagtg cagagcatga gctttggagc ctgcccccac cctagctttg tgaccttaag      120

tgagctacat agcttctcat gtgtaaacta ctcatcataa tggttctgac ctcagtggtt      180

tgttgtgttc taggaaatga tgccagtgaa tgcgtagtcc cagcctcagc acaggggagc      240

caccttgaag ctctcaaata tcactgttgt gaatacagag agggaaaacc aactgtaacg      300

tgccacccaa ataaagctca ttactagtcc tgtccagcaa cgtgcctctc ctggccctag      360

agttcttgga aatagcccag gccaaagaga aggcctttct ccccatggtc agccacacgt      420

tccacatgcg cacagaggag tctgatgcct cacaggaggg cgatgaccta cccaagtcct      480

cagcaaacac cagccatccc aagcaggatg acagccccaa gtcctcagaa gaaaccatcc      540

agcccaagga gggtgacatc cccaaggccc cagaagaaac catccaatcc aagaaggagg      600

acctccccaa gtcctcagaa aaagccatcc agcccaaaga gagtaacatc cccaagtcct      660

cagcaaaacc catccagccc aagctgggca atattcccaa ggcctcagtg aagcccagcc      720

agcccaagga gggtgacatc cccaaggccc cagaagaaac catccaatcc aagaaggagg      780

acctccccaa gtcctcagaa gaagccatcc agcccaaaga gggtgacatc cccaagtcct      840

cagcaaaacc catccagccc aagctgggca atattgccaa gacctcagtg aagcccagcc      900

agcccaagga gagtgatatc cccaagtccc cagaagaaac catccagccc aaggagggtg      960

acatccccaa gtcctcagca aagcccatcc agcccaagct gggcaatatt cccaaggcct     1020

cagtgaagcc cagccagccc aaggagggtg acatctccaa gtccccagaa gaagccatcc     1080

agcccaagga gggtgacctc cccaagtccc tagaggaagc catccagccc aaggagggtg     1140

acatccccaa gtccccagaa gaagccatcc agcccaagga gggtgacatc cccaagtccc     1200

tagaggaagc catccagcct aaggagggtg acatccccaa gtccccagaa gaaaccatcc     1260

agcccaagaa gggtgacatc cccaagtccc cagaagaagc catccagccc aaggagggtg     1320

acattcccaa gtctccaaaa caagccatcc agcccaagga gggtgacatt cccaagtccc     1380

tagaggaagc catcccaccc aaggagattg acatccccaa gtccccagaa gaaaccatcc     1440

agcccaagga ggatgacagc cccaagtccc tagaagaagc caccccatcc aaggagggtg     1500

acatcctaaa gcctgaagaa gaaacaatgg agttcccgga gggggacaag gtgaaagtga     1560

tcctgagcaa ggaggacttt gaggcatcac tgaaggaggc cggggagagg ctggtggctg     1620

tggacttctc ggccacgtgg tgtgggccct gcaggaccat cagaccattc ttccatgccc     1680

tgtctgtgaa gcatgaggat gtggtgttcc tggaggtgga cgctgacaac tgtgaggagg     1740

tggtgagaga gtgcgccatc atgtgtgtcc caacctttca gttttataaa aaagaagaaa     1800

aggtggatga actttgcggc gcccttaagg aaaaacttga agcagtcatt gcagaattaa     1860

agtaaacatg tattctgaaa aca                                             1883


<210> 1427
<211> 1480
<212> DNA
<213> Homo sapiens

<400> 1427
ctcccatacc ctataacttt gtttgttcta tttcacacat ataattttcc gagacaagat       60

gttctcattt aagcaacaag aagattcgtc tctcgctatt actgtaactg ctgtttatat      120

cgtcatgtcc cggaaaggtc cctgtcttcc ctgaatggtc tctaccaact tcacctccgg      180

ttctaggtgt catggctgcc ccaagagtct aggtaagagt ttgttcccgt ggtgcggagg      240

gtcaaggccc acacccggaa acctagcgag gtaaagttgc gtcttggttg tagagacgac      300

aacttctccg cttcctcggc gatggcggcg tccgggagcg gtatggccca gaaaacctgg      360

gaactggcca acaacatgca ggaagctcag agtatcgatg aaatctacaa atacgacaag      420

aaacagcagc aagaaatcct ggcggcgaag ccctggacta aggatcacca ttactttaag      480

tactgcaaaa tctcagcatt ggctctgctg aagatggtga tgcatgccag atcgggaggc      540

aacttggaag tgatgggtct gatgctagga aaggtggatg gtgaaaccat gatcattatg      600

gacagttttg ctttgcctgt ggagggcact gaaacccgag taaatgctca ggctgctgca      660

tatgaataca tggctgcata catagaaaat gcaaaacagg ttggccgcct tgaaaatgca      720

atcgggtggt atcatagcca ccctggctat ggctgctggc tttctgggat tgatgttagt      780

actcagatgc tcaatcagca gttccaggaa ccatttgtag cagtggtgat tgatccaaca      840

agaacaatat ccgcagggaa agtgaatctt ggcgccttta ggacataccc aaagggctac      900

aaacctcctg atgaaggacc ttctgagtac cagactattc cacttaataa aatagaagat      960

tttggtgtac actgcaaaca atattatgcc ttagaagtct catatttcaa atcctctttg     1020

gatcgcaaat tgcttgagct gttgtggaat aaatactggg tgaatacgtt gagttcttct     1080

agcttgctta ctaatgcaga ctataccact ggtcaggtct ttgatttgtc tgaaaagtta     1140

gagcagtcag aagcccagct gggacgaggg agtttcatgt tgggtttaga aacgcatgac     1200

cgaaaatcag aagacaaact tgccaaagct acaagagaca gctgtaaaac taccatagaa     1260

gctatccatg gattgatgtc tcaggttatt aaggataaac tgtttaatca aattaacatc     1320

tcttaaacag tctctgagaa gtactttacc tgaaagacag tatgagaaaa atattcaagt     1380

aacactttaa aaccagttac ccaaaatctg attagaagta taaggtgctc tgaagtgtcc     1440

taaatattaa tatcctgtaa taaagctctt taaaatgaaa                           1480


<210> 1428
<211> 2609
<212> DNA
<213> Homo sapiens

<400> 1428
ccttgtcgca cgtcgcagcg cctggcgccc gggaagaggt ggttgtgagg cagacgaact       60

cgcggctctc cggcttccga ggcttccgag ttgtcggagg aagggggcgg cgagcaataa      120

gaacccgccg cacccggtcc tcagcgactc ttctgacctc cgcgcgacgt acccgccgcc      180

gccgttggct ggagcatttg acattgtgca gcaaagaaat ggttatggag aagcccagtc      240

cgctgcttgt agggcgggag tttgtgaggc aatattatac tttgctgaat aaagctccgg      300

aatatttaca caggttttat ggcaggaatt cttcctatgt tcatggtgga gtagatgcta      360

gtggaaagcc ccaggaagct gtttatggcc aaaatgatat acaccacaaa gtattatctc      420

tgaacttcag tgaatgtcat actaaaattc gtcatgtgga tgctcatgca accttgagtg      480

atggagtagt tgtccaggtc atgggtttgc tgtctaacag tggacaacca gaaagaaagt      540

ttatgcaaac ctttgttctg gctcctgaag gatctgttcc aaataaattt tatgttcaca      600

atgatatgtt tcgttatgaa gatgaagtgt ttggtgattc tgagcctgaa cttgatgaag      660

aatcagaaga tgaagtagaa gaggaacaag aagaaagaca accatctcct gaacctgtgc      720

aagaaaatgc taacagtggt tactatgaag ctcaccctgt gactaatggc atagaggagc      780

ctttggaaga atcctctcat gaacctgaac ctgagccaga atctgaaaca aagactgaag      840

agctgaaacc acaagtggag gagaagaact tagaagaact agaggagaaa tctactactc      900

ctcctccggc agaacctgtt tctctgccac aagaaccacc aaagccaaga gtcgaagcta      960

aaccagaagt tcaatctcag ccacctcgtg tgcgtgaaca acgacctaga gaacgacctg     1020

gttttcctcc tagaggacca agaccaggca gaggagatat ggaacagaat gactctgaca     1080

accgtagaat aattcgctat ccagatagtc atcaactttt tgttggtaac ttgccacatg     1140

atattgatga aaatgagcta aaggaattct tcatgagttt tggaaacgtt gtggaacttc     1200

gcatcaatac caagggtgtt gggggaaagc ttccaaattt tggttttgtg gtttttgatg     1260

actctgaacc agttcagaga atcttaattg caaaaccgat tatgtttcga ggggaagtac     1320

gtttaaatgt ggaagagaaa aaaacaagag ctgcaagaga gcgagaaacc agaggtggtg     1380

gtgatgatcg cagggatatt aggcgcaatg atcgaggtcc cggtggtcca cgtggaattg     1440

tgggtggtgg aatgatgcgt gatcgtgatg gaagaggacc tcctccaagg ggtggcatgg     1500

cacagaaact tggctctgga agaggaaccg ggcaaatgga gggccgcttc acaggacagc     1560

gtcgctgaag ctccactgtt ggcaaagtct tggcagtggt acattattca tcgtgtttgc     1620

attcttgtta attttttttt tggctttgga atgtgacaca gcctttttga tcatttcttt     1680

gatgtgaaaa gcatctttgg ttatcagtta aattgaggtg gacattattt ccccaatttc     1740

acaacaggat tcacattgtt aatttataaa tctagacttg gagaattaag gactgagaaa     1800

tgaccatatc ttaaactatc tacgacaaag tgaacttaaa aggacatgcc cactgaattc     1860

aggtcctttg agtaaaaaaa aaatcttctg ctgcacattt tgtttaagtg ttactgtttc     1920

tgcctgttaa tgctgggaac acaaatagtg caatttgtgc aattggagaa tcttgccttt     1980

tttcttggct ccccccaaaa atacaaacca acagaaactt gttatgcact catcaaaatg     2040

tactaatggg tactctgaac tcattaacat tgacatctgc aacaggaggc aacagggaaa     2100

aaatctcatc ttcttttcca gtagaaaata gtttgtgaaa tgatgagggc attttatctg     2160

cttgctgtga ccagcgtgtg tacacataaa ccttaacaag actacaagta tattccagaa     2220

ggaaatcatt ttagttatga actaaataat aaaaattaga acttcaaatg cgatggtctt     2280

gactattaga ccagatttag tagctccata tctaagattt ttctacctgc ccctcttcag     2340

tacagggatg gctggctgct caacacactc ctcctcccct tttttccttt ctttaagctg     2400

tgtacagtga aaattgtctt tactgtattt ttgttctctg gtaatgtaat aagcatgatg     2460

gtgccttcta ttaatacatc attccagtct tgctggtaat tttgtacagt atagtgtatg     2520

aattgctgtg ctgcaaagcc aaacagctgc aaaatgttga aaaatcatcg aaatgtataa     2580

aaattgcagt atctttaaaa tcagtaaaa                                       2609


<210> 1429
<211> 1370
<212> DNA
<213> Homo sapiens

<400> 1429
cagtgagtta gcatggaggg cagtgggacc ggaaaaagac gtggaaaagc tgcgaaaacg       60

agccttcgaa tcatggacgc gcgggcccag ctcctcctcc gagttcctca tccggggccg      120

tcactcacat ccggggccct cactcacatc cgggaccctc atccggggct ctcacccaca      180

tccgggaccc tcatgcctgg gcggaggagg gggggccctc attcgggacc ctgcactccg      240

tcgccggaag tgccaccgag aagcgccggc ctcggggctg tctacagcgg cccgggagag      300

gctgtggtgg ccccgagcgc gagtgtgtag gtgacaggac agcggccagg cccgcccctc      360

ccctcgtgat ggtcattgtc ctccagagca gtgatggagg aaataccagc ccaggaagca      420

gcagggtcac caagggtcca gtttcagtct ttggagaccc agtctgagtg tctgtcccca      480

gagcctcagt ttgtgcagga caccgacatg gaacagggac tcactggggg catacttctc      540

cgccttccca ccacccggat tcatagtgtg aattcctgcc cggccctgag tcatacccag      600

gcaagtgctt tctctggaga aacacttgcc gtccttacag caggaatctc caagagatgg      660

cccaagtatc ggcttcccat cgatattgct cgtccctgct cggaaactcc ttttccacga      720

ttgtgagata ttaaaattga ctgatggaat agaagctccc caggatgcca ccactgtgta      780

aaatcgcagc tcctcaaatt acctctgttt aatttcaaat gttagggtcc aaggaagccc      840

tctgttgcaa ccagatatgt tttgaaccca gttcattcag aaaccatggt tggtggtcat      900

catctacttg tattgtgaaa aaccagaaat tccaaattca gctcttcagt tatggtcttt      960

tcatattatt ttagaatgtg aaacttatgc tgtgtgcccc tccttttatg tggcgaacac     1020

aacctgcccc gtatggtgcc taactctcct gtgaaccctg ggcttccctc atgtttaaca     1080

ttctggtttc ctccttcctt gaagtccctg tggccctctt caaggtccta ccttcctacc     1140

ctttattctt tgtggttctg tacagattga tgcaattata ttgcctttcc tgattaagtg     1200

ttccttactc tgtccttgat ggaggggaga agggagggca aagaagttaa atttatttca     1260

gggcatcaaa ttgaatatct acttaataac tttgtaaact gtaaagtgac atacatataa     1320

ttgtaaagta ctgttaattt tatctaataa ttacagagtt tccaacagtt                1370


<210> 1430
<211> 1439
<212> DNA
<213> Homo sapiens

<400> 1430
ccctctctgg aacactgtct ccactgagtt ttaggtaagt gtgtgacaga caaacgagca       60

gaagcttgga gaagctcagg gtggatcttg gtggccggag ctactgtctc ggcgcatgag      120

cttggaagct tcaggaagca gggctgggga agcaccctcc aggctgcagt tccagggaag      180

gcaatactga acactgcgca gcttgcagag gtctcctggc agccctcatt aggaattctg      240

tctggccccg atcagaatac tggagacgag accacgagat tgatgagttt gccttgggag      300

tcggtaagaa ggtgaagcca ggggcgaaca tgggtcagaa ggtcactgga gggatcaaga      360

ctgtggacat gagggacccc acgtacaggc ccctgaagca ggagctccag ggtctggatt      420

actgcaagcc cacccggctg gatctgctac tggacatgcc ccctgtgtcc tatgatgtcc      480

agctgctgca ttcatggaac aacaacgacc gatcgctcaa tgtctttgtg aaggaggacg      540

acaagctcat ctttcaccgg catccggtgg cccagagcac ggacgctatc aggggcaaag      600

tcgggtatac ccgtgggctg cacgtgtggc agatcacgtg ggccatgaga cagcggggca      660

cacacgccgt ggtgggggtg gcgacggcag acgcccccct gcactctgtc gggtacacaa      720

ccctcgtggg gaataaccac gagtcctggg gctgggactt ggggcgcaac cggctctacc      780

acgatggcaa gaaccagcca agcaaaacat acccagcctt tctggaacca gatgagacat      840

tcattgtccc tgactccttc ctggtagccc tggacatgga cgacgggact ctgagcttca      900

ttgtggatgg acagtacatg ggagtggctt ttcggggact caagggcaaa aaactgtatc      960

ctgtagtgag tgccgtctgg ggccactgtg agatccgaat gcgctacttg aacggactcg     1020

atcccgagcc gctgccgctc atggatttgt gccgtcgctc ggtgcgcctg gccctgggga     1080

gggagcgcct gggggagatc cacacgctgc cgctgccggc ttccctcaag gcctacctcc     1140

tctaccagtg acgttcgcca tcataccgcc agcgcgacag ccacctggtg ccaactcact     1200

gagccgcctg ccgctggggc cgccgcaccc tgcaccttgg accggcatcc gtagccatgg     1260

acagaggtcc ctggtcttcc ctcatcctcc gtggctgcct ccatgggaca aggaccgatt     1320

ccaacacagg ctcctctttc ccccttcccg acatcagcag aaggcagcat ccctgcatgc     1380

cgtccgtata caacccctct ttgaaaaaag acacagagaa taaactccta cgaaagccc      1439


<210> 1431
<211> 4295
<212> DNA
<213> Homo sapiens

<400> 1431
aggccgccgc ctgggtcgct caacttccgg gtcaaaggtg cctgagccgg cgggtcccct       60

gtgtccgccg cggctgtcgt cccccgctcc cgccacttcc ggggtcgcag tcccgggcat      120

ggagccgcga ccgtgaggcg ccgctggacc cgggacgacc tgcccagtcc ggccgccgcc      180

ccacgtcccg gtctgtgtcc cacgcctgca gctggaatgg aggctctctg gaccctttag      240

aaggcacccc tgccctcctg aggtcagctg agcggttaat gcggaaggtt aagaaactgc      300

gcctggacaa ggagaacacc ggaagttgga gaagcttctc gctgaattcc gagggggctg      360

agaggatggc caccaccggg accccaacgg ccgaccgagg cgacgcagcc gccacagatg      420

acccggccgc ccgcttccag gtgcagaagc actcgtggga cgggctccgg agcatcatcc      480

acggcagccg caagtactcg ggcctcattg tcaacaaggc gccccacgac ttccagtttg      540

tgcagaagac ggatgagtct gggccccact cccaccgcct ctactacctg ggaatgccat      600

atggcagccg agagaactcc ctcctctact ctgagattcc caagaaggtc cggaaagagg      660

ctctgctgct cctgtcctgg aagcagatgc tggatcattt ccaggccacg ccccaccatg      720

gggtctactc tcgggaggag gagctgctga gggagcggaa acgcctgggg gtcttcggca      780

tcacctccta cgacttccac agcgagagtg gcctcttcct cttccaggcc agcaacagcc      840

tcttccactg ccgcgacggc ggcaagaacg gcttcatggt gtcccctatg aaaccgctgg      900

aaatcaagac ccagtgctca gggccccgga tggaccccaa aatctgccct gccgaccctg      960

ccttcttctc cttcatcaat aacagcgacc tgtgggtggc caacatcgag acaggcgagg     1020

agcggcggct gaccttctgc caccaaggtt tatccaatgt cctggatgac cccaagtctg     1080

cgggtgtggc caccttcgtc atacaggaag agttcgaccg cttcactggg tactggtggt     1140

gccccacagc ctcctgggaa ggttcagagg gcctcaagac gctgcgaatc ctgtatgagg     1200

aagtcgatga gtccgaggtg gaggtcattc acgtcccctc tcctgcgcta gaagaaagga     1260

agacggactc gtatcggtac cccaggacag gcagcaagaa tcccaagatt gccttgaaac     1320

tggctgagtt ccagactgac agccagggca agatcgtctc gacccaggag aaggagctgg     1380

tgcagccctt cagctcgctg ttcccgaagg tggagtacat cgccagggcc gggtggaccc     1440

gggatggcaa atacgcctgg gccatgttcc tggaccggcc ccagcagtgg ctccagctcg     1500

tcctcctccc cccggccctg ttcatcccga gcacagagaa tgaggagcag cggctagcct     1560

ctgccagagc tgtccccagg aatgtccagc cgtatgtggt gtacgaggag gtcaccaacg     1620

tctggatcaa tgttcatgac atcttctatc ccttccccca atcagaggga gaggacgagc     1680

tctgctttct ccgcgccaat gaatgcaaga ccggcttctg ccatttgtac aaagtcaccg     1740

ccgttttaaa atcccagggc tacgattgga gtgagccctt cagccccggg gaagatgaat     1800

ttaagtgccc cattaaggaa gagattgctc tgaccagcgg tgaatgggag gttttggcga     1860

ggcacggctc caagatctgg gtcaatgagg agaccaagct ggtgtacttc cagggcacca     1920

aggacacgcc gctggagcac cacctctacg tggtcagcta tgaggcggcc ggcgagatcg     1980

tacgcctcac cacgcccggc ttctcccata gctgctccat gagccagaac ttcgacatgt     2040

tcgtcagcca ctacagcagc gtgagcacgc cgccctgcgt gcacgtctac aagctgagcg     2100

gccccgacga cgaccccctg cacaagcagc cccgcttctg ggctagcatg atggaggcag     2160

ccagctgccc cccggattat gttcctccag agatcttcca tttccacacg cgctcggatg     2220

tgcggctcta cggcatgatc tacaagcccc acgccttgca gccagggaag aagcacccca     2280

ccgtcctctt tgtatatgga ggcccccagg tgcagctggt gaataactcc ttcaaaggca     2340

tcaagtactt gcggctcaac acactggcct ccctgggcta cgccgtggtt gtgattgacg     2400

gcaggggctc ctgtcagcga gggcttcggt tcgaaggggc cctgaaaaac caaatgggcc     2460

aggtggagat cgaggaccag gtggagggcc tgcagttcgt ggccgagaag tatggcttca     2520

tcgacctgag ccgagttgcc atccatggct ggtcctacgg gggcttcctc tcgctcatgg     2580

ggctaatcca caagccccag gtgttcaagg tggccatcgc gggtgccccg gtcaccgtct     2640

ggatggccta cgacacaggg tacactgagc gctacatgga cgtccctgag aacaaccagc     2700

acggctatga ggcgggttcc gtggccctgc acgtggagaa gctgcccaat gagcccaacc     2760

gcttgcttat cctccacggc ttcctggacg aaaacgtgca ctttttccac acaaacttcc     2820

tcgtctccca actgatccga gcagggaaac cttaccagct ccagatctac cccaacgaga     2880

gacacagtat tcgctgcccc gagtcgggcg agcactatga agtcacgttg ctgcactttc     2940

tacaggaata cctctgagcc tgcccaccgg gagccgccac atcacagcac aagtggctgc     3000

agcctccgcg gggaaccagg cgggagggac tgagtggccc gcgggcccca gtgaggcact     3060

ttgtcccgcc cagcgctggc cagccccgag gagccgctgc cttcaccgcc ccgacgcctt     3120

ttatcctttt ttaaacgctc ttgggtttta tgtccgctgc ttcttggttg ccgagacaga     3180

gagatggtgg tctcgggcca gcccctcctc tccccgcctt ctgggaggag gaggtcacac     3240

gctgatgggc actggagagg ccagaagaga ctcagaggag cgggctgcct tccgcctggg     3300

gctccctgtg acctctcagt cccctggccc ggccagccac cgtccccagc acccaagcat     3360

gcaattgcct gtcccccccg gccagcctcc ccaacttgat gtttgtgttt tgtttggggg     3420

gatatttttc ataattattt aaaagacagg ccgggcgcgg tggctcacgt ctgtaatccc     3480

agcactttgg gaggctgagg cgggcggatc acctgaggtt gggagttcaa gaccagcctg     3540

gccaacatgg ggaaaccccg tctctactaa aaatacaaaa aattagccgg gtgtggtggc     3600

gcgtgcctat aatcccagct actcgggagg ctgaggcagg agaatcgctt gaacccggga     3660

ggtggaggtt gcggtgagcc aagatcgcac cattgcactc cagcctgggc aacaagagcg     3720

aaactctgtc tcaaaataaa taaaaaataa aagacagaaa gcaaggggtg cctaaatcta     3780

gacttggggt ccacaccggg cagcggggtt gcaacccagc acctggtagg ctccatttct     3840

tcccaagccc gagcagaggg tcatgcgggc cccacaggag aagcggccag ggcccgcggg     3900

gggcaccacc tgtggacagc cctcctgtcc ccaagctttc aggcaggcac tgaaacgcac     3960

cgaacttcca cgctctgctg gtcagtggcg gctgtcccct ccccagccca gccgcccagc     4020

cacatgtgtc tgcctgaccc gtacacacca ggggttccgg ggttgggagc tgaaccatcc     4080

ccacctcagg gttatatttc cctctcccct tccctccccg ccaagagctc tgccaggggc     4140

gggcaaaaaa aaaagtaaaa agaaaagaaa aaaaaaaaaa agaaacaaac cacctctaca     4200

tattatggaa agaaaatatt tttgtcgatt cttattcttt tataattatg cgtggaagaa     4260

gtagacacat taaacgattc cagttggaaa catgt                                4295


<210> 1432
<211> 7643
<212> DNA
<213> Homo sapiens

<400> 1432
gcgggtcgtt agctgtcaga gccaagcggc gggctggcgg cgggctccga cgtctgcgcc       60

aggacctggc tggctgagcc cggcgcagca gcagcagcca gggcagcgcg gcccctactc      120

cctgtcaggt cgtagaggcg agcagggacc agctggtcgc cggcccctcg ggcaagatgg      180

ggaaccggga gatggaggag ctgatcccgc tggtgaaccg tctgcaggac gcgttttcgg      240

cgctgggaca gagctgcctg ctggagctgc cgcagatcgc cgtggtgggc ggccagagcg      300

ccggcaagag ctcggtgctc gagaacttcg tgggcaggga ctttctccct cgagggtcgg      360

gcattgtaac aagacgacct cttgtgctgc agcttgttac ttctaaagca gaatatgccg      420

agtttctaca ttgcaaagga aagaaattta cagattttga tgaagttcgc cttgagattg      480

aagcagaaac agatcgcgtg actggaatga ataaaggcat ttcctccata cccattaatt      540

tacgagtcta ttccccacac gtgttaaatc taacccttat tgatctacct ggaataacta      600

aagtgcctgt gggagatcag ccaccagata tcgagtatca gatcagagaa atgattatgc      660

agttcatcac gagggagaac tgtctgattt tagctgttac tccagccaac actgatcttg      720

caaactcaga tgcgctgaag ctagctaaag aagttgatcc tcaaggtctg agaaccattg      780

gagttatcac caaactggac cttatggatg aaggaacgga tgccagggat gttctagaga      840

acaaactgtt gcctcttcgc aggggttacg tgggggtggt aaacagaagc cagaaggaca      900

tagatgggaa gaaggacata aaggcagcca tgctggcaga gaggaagttt ttcctttccc      960

acccggctta cagacatatc gctgaccgaa tgggaacccc acacctgcag aaggtcctta     1020

atcagcaact taccaaccac attcgggata ccctaccaaa cttcaggaac aaactacagg     1080

gacagttgct ctccatagaa catgaagtag aagcctacaa aaatttcaaa ccagaagacc     1140

caacaaggaa gaccaaagca ttgctgcaga tggttcagca atttgctgtg gactttgaga     1200

agagaattga agggtcaggg gatcaagtag ataccctgga actctcaggt ggtgctaaaa     1260

tcaatcgtat ttttcatgaa cgctttcctt ttgagatagt aaagatggag ttcaatgaga     1320

aagaattgcg aagagaaata agctatgcaa tcaaaaacat acatggtatc aggacagggt     1380

tgtttactcc agacatggca tttgaagcga tagtcaagaa acagattgta aagttgaaag     1440

ggccttcctt gaagagtgtg gatctggtaa tacaagaatt aatcaacact gtgaagaagt     1500

gtaccaaaaa actggcaaac ttccccagac tctgcgagga aacggaaagg attgttgcta     1560

accacattcg tgagcgagaa gggaagacaa aggaccaggt attgctattg attgacattc     1620

aagtctctta catcaacacc aaccatgaag acttcattgg cttcgcaaat gctcagcaga     1680

ggagcagtca ggttcacaag aaaaccacag ttggaaatca ggtgattcgc aaggggtggc     1740

tcaccatcag caacattggc atcatgaaag gcggctcgaa gggatactgg ttcgtcctta     1800

ctgcggaaag cttgtcctgg tataaagatg atgaggaaaa agaaaagaag tacatgcttc     1860

ccttggacaa cctgaaagtt cgggatgtgg aaaagagctt tatgtctagc aagcacatct     1920

ttgcactctt taatacagag caaaggaatg tatacaaaga ctatcgcttc cttgagctgg     1980

catgtgattc ccaggaggat gtcgacagct ggaaggcatc tctactaaga gctggggtct     2040

atcctgacaa atctgtaggg aacaacaaag ctgaaaatga tgagaatgga caagcagaaa     2100

acttttccat ggacccacaa ttggagaggc aagtggagac cattcgcaac ctcgtagact     2160

cctacatgtc cattatcaac aaatgtatcc gagatctaat tccaaaaaca ataatgcacc     2220

ttatgatcaa taacgttaaa gatttcataa attccgagct cctagcacag ttgtattctt     2280

cagaggacca aaataccctg atggaggaat ctgctgagca ggctcagcgc cgggatgaga     2340

tgcttcgaat gtatcaagca ctgaaagaag cccttgggat aattggggac atcagcacag     2400

ccaccgtgtc cactccggca ccccctccag tggatgactc ctggatacag cactctcgca     2460

ggtcacctcc tccaagcccc acaacccaaa ggaggccaac actaagtgct cccctcgcaa     2520

ggcccacatc cggccgagga ccagctcctg ccattccctc tcctggcccc cactctgggg     2580

ctcctccagt cccattccgt ccaggcccat tacctccttt ccccagcagc agtgactcct     2640

tcggagcccc tccacaagtt ccatctaggc ctacgagggc cccgcccagt gtcccaagcc     2700

ggagaccacc cccatcacca actcgtccca ctataatccg cccactagaa tcctccctgt     2760

tagactaaac gaagtgtctg gcatggcaat taatcactaa tgaattatgc gaaagcaaca     2820

tatttgataa ccgttgcagt aaatcatgag tagtcgcatg tgtggacatc agtaggcaag     2880

taaccagttt tactaatgca ttcatcgctc atcttcattg ctcatggtat gtcaaacctt     2940

tggggtttga ctcagaaact gctaaccttt tagaggcttt atatgttgta ctgaccaagg     3000

taggtttgta tagcagccct atactttggg gatcatttgc ctaccatggc atatatttga     3060

aattgctttg gacaagtttt ctaggctatc taccaggtag ctcattaaac gtaattcttc     3120

agatatgaga tagtgggctt agacctaagc catacatatt tcttttccca cattctgttt     3180

aggatgacag taattctgtt gtctaccatt aatgctacta cctactccat aattgcctat     3240

ttagctcctc ttttcttcct ttttatttca taagactgct aggaagtgat tttttaaaat     3300

taggactcct taagaataaa cttttccaga agcacgaggt agtttgcaaa ggaaaagtct     3360

gcactgtttg ctctaaagag cttctcctca ttccaatgtg ttttgcttca tgctagaagc     3420

atatgcaaca gtgaataaaa gcttcttttt ttgttaatca gtcaataaat ttggctaatt     3480

agtttcagag ttcaaggaag aagcaaaata tcacatctct agaagtgttg ggaaaaatat     3540

aatttctttc tttacttata ttcacctcat ggtaggttat attgaaggct gacatggaga     3600

atgtttactt ttctatttgg catagctaac tacactttga tactaactcc agttttacta     3660

ttattatttt ggttggaaaa aaaattcact ctttacgtgc taatttgtaa tcttgttttg     3720

taagaattta tcctaccctt gaaacaggct cagtgtaact gtatatccat tctaggcttt     3780

cttaataaat cttgaggcta tgggataatc acatttaaag aatggttcct gaaatgaagt     3840

cagtagaaat ggcatgggat aagagcagag ctcacacttt tacagttgca gtatttcaaa     3900

gtccctatcc aggtcactcc agaaaagggt attgaaacgt tgaaatctaa agcaaatttg     3960

caatttctta agatttctaa aatttaccag aacagtttag cctgggggtt aatagttaag     4020

tcttgaggct aagttttgga ctaccaagga ccagatgatt cacatgtagg aaacagccag     4080

aagccaactg gaattttgtg tgctaactgt tcccagacag cagagcaagt attcactgag     4140

taggggtgtc ccatgacact atttcatatt ctacagaagt aaatcaggtt tcaccaactg     4200

aaatgtctcc ctttgaaagt agcaaacatg atttgtatgt taacttaact ttaatttcct     4260

gtgtagttta cacccagagc agatactcat aaagtataaa gtaaaaactt ttaaccatta     4320

ttaaacagag aacttgccat gttgagtgcc attgtattga acttattcta aaggcttatg     4380

ctaacccatt tataattggt aaaaatcaga aaatacaaga tttacataaa ggtcatttca     4440

acttttaagg ttaccagtga ttgtataaaa acatcacaat cctaaatcct ctcgtatctc     4500

accccaaacc ccaaactggg ggaaaaaaag ttaactcttt gtgaatggaa ccaatgtgca     4560

agatacatac tgcattttta aaatagtgtc tcagctaaat ggaaaactgt taagcaaaca     4620

tccatagtaa aacaaataat cttcagtgag atctttttat aaaacttctt gtttttagga     4680

ttccctttgc ttcttccttt gaattctcta aaataggcag ctaacggatt atatacttca     4740

gggtttggct ttgtgctaaa tgtggttttg tgttttgctg tatttcaaaa ttttccttct     4800

gttaaaggaa aatattgtga ataaccactg gtgtgttctt agatcagcac aaaccatgtc     4860

aaaaaaaatt ggagattttt ttccaatttt ccttccactg atcttaggca gtaataaaca     4920

atggcatttg tcatctttgg cacttgcttt tagattatag tcccacagtt gcactgcccc     4980

aattgtctac ctttgtgggt acatttttgt tctttactcc taagttattt ctcatagaac     5040

ccagcctact ctagaatttc agcagtgaca ttggagaata tttttaattt gctgcagtac     5100

tatgtcatat tattagtatg aatctcattt cccaaagggt ttgtattctg ctaaaaggag     5160

atgccaatgt tgaatgaagt ctgaaactct agtatgtgca tagtttgacg tgcagcatgc     5220

acaccaggcc ttaagatggg aatgtagctt aatgattttc tgtttcccat accatttcta     5280

atcttttgtg taattttctc ttaactgatt gctctgatat tgtaaacaca atagatgtag     5340

ctctatcatg tctagcataa tttaaaaaat cagtgttttt aggatttggg aaaataaact     5400

gtaaatgttt atttgatagg taaatatagt tttattgtca catgctaaat attgcatgca     5460

tattgactaa ttggaataac catttactca attatggaca gcttattgaa atagtattga     5520

tttagaaaaa gtatattgca tttctaaaaa acatctacca aggttactcg tctgaatatt     5580

gcttttagcc gtgttttata acatagacga gcagtagggt ctgtttatta gcaaatttcc     5640

tatttgttcc aatacaaact cactttattc taaagtatat taatgaaacc agttcctgtg     5700

atgtaactgt aagccttctc gacttagact taaaaagtgg tcacatagat taattttgtg     5760

actttttagt atagactgta gccataattc tcaaatatga aatgggacct aataccagta     5820

tgtgataaat gttgatgttt tctgtgtaca aacacatttt ctatgcatgt gtctctgtgt     5880

atatggcata tacctagtaa gtatgtttct gtaagtatgt gtattttatg tccatttgag     5940

taggtaggta ggttttaaaa atactagtta aaatgccaca agcatgagtg tgattgtatg     6000

tgcactgtgt gtatatatat aaatatatgt atatgtatgg ttgtaaatat ctatgtatac     6060

atgtacttag tatgtgtggt atcaggatat tttttaaact gtgataatac aacagatagc     6120

tttgaatgat ctgccataac atgtggtaac aatagttcat ttctcataac atatatgagg     6180

tatacaaaat tttctaactc cagattgtag tcattttgag aggtacaaag ctcataatta     6240

ccatgacaac atggtaatgt ccatagacat ttgtatctga atccacaaga agatctgaat     6300

ctaagaagga attacctttg acaatatttt tcggtaagaa gtaaaacctc tggagaccta     6360

tctttaagat ctctaattgg aattataaat tatttttgga ttgctgagct gaatcttaaa     6420

aagccaagtt gatatacata gtcatttttc ctctatggta gaagtaaaaa aaaaaaaaaa     6480

ggacatagca acattaaagt agtggatttt tctgagtaaa tttgctgaaa atataagaga     6540

gaagctatct aataccttgg aggtaggtca tccacttttt caggtaaaca tttttcattt     6600

ggcaaatggc ataattattt gaaagtgaca ggaatctcct cagaatgaag aataaagcct     6660

actaggtctc taactgttga actcatgaaa gaagatagtg tatgagactt aagccatgag     6720

ttttgtatca tttcaattag aagactacta gctgtgagct cagagtttaa tgtaaatgaa     6780

tctagatgat tttgaagaaa tgattattcg ttcaccagat cactcattgt acattctaaa     6840

aagctcaaat gagtcttcta gatactctta ctcatcctgt ctggttgcta tgtttaaaat     6900

tatgtggtgc tgtgtaggtg aaactttaag aatatttttg aagcatatgt aatatatgca     6960

ctgctatttg tgtgtgtgtg tgtgtctttg tatatatgta agaatgtgtg tatgtgtgag     7020

agcaagagag aggaaactca aagaggagtg tttgtcttaa gacctgttca tactggtata     7080

ttggtgagac ttctcacttc tggttggagg tttcacatat ggctcaactc aagtcattaa     7140

tctcttttta atttttactc ttgaattcct taaacttcgc tcattatgaa atgttttaaa     7200

attatgacaa aaattactct gtctaaccac ttgccttgtc tgctaccagt ttgttaaaaa     7260

ttattccccc caaccagtaa ttccaccagt actacttgat ttgtgttata tttcctatgt     7320

acatgtacag cctttgtttt gcttgcttgt ctatttttac tttccctttt ttgggtcaaa     7380

tttttctttt gctttgtttg aagaaggaat atacagaagt aaaatcttgt cttctctgct     7440

gattctttaa ttaatatgag ccggatactt tccactgtct tcttggcact ttcaggattt     7500

cttaatgctg atatatggac tcttagaatg gaatttttga agaaaaatct caaagcctgt     7560

atcgttcttg aaggtcacat gtacctattg tgaaaatgtg aagctgtatt tctgaagctg     7620

aaataaatta taacatttga agg                                             7643


<210> 1433
<211> 1822
<212> DNA
<213> Homo sapiens

<400> 1433
agtagcgggc ggcagagctg gagtgaaggg agctagtggt aaagggagct ggtggagggg       60

tggcggcagg ggtaaggggc aggggacacc ctctagacgg agagcgggct ccgaggtcct      120

ggctggccct cggtgcgccc gcccctgtgt tggtcccaca atccctggca atgagaggcc      180

agggtttatt ggacagagtc agttgtgggg ttcagagggt cagcaatcaa tcaatcctcc      240

gaatccagag atttagaccc agtcgtccgt attaggactg gaggggggtc aataggttca      300

gtgtttgaga tgccaaggga acctgtcttt tgatttgggg ttcaacatac agaggtagca      360

gtcaccatta tgctcaaagc ggtgatcctg attggaggcc ctcaaaaggg aactcgcttc      420

agacctttgt cttttgaggt gcccaaacca ttgtttcctg tggcaggggt ccctatgatc      480

caacaccata ttgaagcctg tgcccaggtc cctggaatgc aggagattct gctcattggc      540

ttctaccaac ctgatgagcc cctcacccag ttcctagaag ccgcccagca ggagtttaac      600

cttccagtca ggtacctgca ggaatttgcc cccctaggca cagggggtgg tctttaccat      660

tttcgagacc agatcctggc tgggagcccc gaggcattct tcgtgctcaa tgctgatgtc      720

tgctccgact tccccttgag tgctatgttg gaagcccacc gacgccagcg tcaccctttc      780

ttactccttg gcactacggc taacaggacg caatccctca actacggctg catcgttgag      840

aatccacaga cacacgaggt attgcactat gtggagaaac ccagcacatt tatcagtgac      900

atcatcaact gcggcatcta cctcttttct cctgaagcct tgaagcctct tcgggatgtc      960

ttccagcgta atcagcagga tgggcaattg gaggactcac caggcttgtg gccaggggca     1020

ggtaccatcc gcctagagca ggatgtgttt tcagccctgg cagggcaggg ccagatatac     1080

gtgcatctca ctgatggtat ctggagtcag atcaagtccg caggttcagc cctctacgcc     1140

tcccgcctct acctgagccg ataccaggac actcacccag aacggctggc caagcacacc     1200

ccagggggcc catggatccg agggaatgtg tacatccacc cgaccgccaa ggtggccccc     1260

tcggctgtgc tgggccccaa cgtctccatc gggaaggggg tgaccgtggg tgagggtgtg     1320

cggctccggg agagcatcgt cctccatgga gccactttgc aggagcacac gtgtgttctg     1380

catagcatcg tgggctgggg gagcaccgtg ggacgctggg cccgcgtgga gggtaccccc     1440

agtgacccta accccaacga tccccgagcc cgcatggaca gtgagagcct cttcaaggac     1500

gggaagctgc tgcctgctat caccatcctg ggctgccgag tccggatccc tgccgaggtg     1560

ctcatcctga actcgattgt tctgccacac aaggagctga gccgaagctt caccaaccag     1620

atcatcctct gagtagggct gccagaaggc ccccagctcc tacccactcc ccttgaggct     1680

gctgcctgct tggccagcct ctgtccagaa aggaccagag aaagccaggc tggatcgtca     1740

catgccgggg agcaatgtgg atggcctggg gactcctggg ttttctccct cccgactccc     1800

taataaaccc cgtgaacctt gg                                              1822


<210> 1434
<211> 5849
<212> DNA
<213> Homo sapiens

<400> 1434
agtagttccg ctccgagggc ggaagtgcgc gtctcttgtt tgtgcggctg accagttggc       60

gacatggtgg cacccgtgct ggagacttct cacgtgtttt gctgcccaaa ccgggtgcgg      120

ggagtcctga actggagctc tgggcccaga ggacttctgg cctttggcac gtcctgctcc      180

gtggtgctct atgaccccct gaaaagggtt gttgttacca acttgaatgg tcacaccgcc      240

cgagtcaatt gcatacagtg gatttgtaaa caggatggct ccccttctac tgaattagtt      300

tctggaggat ctgataatca agtgattcac tgggaaatag aggataatca gcttttaaaa      360

gcagtgcatc ttcaaggcca tgaaggacct gtttatgcgg tgcatgctgt ttaccagagg      420

aggacatcag atcctgcatt atgtacactg atcgtttctg cagctgcaga ttctgctgtt      480

cgactctggt ctaaaaaggg tccagaagta atgtgccttc agactttaaa ctttggaaat      540

ggatttgctt tggctctctg cttatctttt ttgccaaata ctgatgtacc aatattagca      600

tgtggcaatg atgattgcag aattcacata tttgctcaac aaaatgatca gtttcagaaa      660

gtgctttctc tctgtggaca tgaggattgg attagaggag tggaatgggc agcctttggt      720

agagatcttt tcctagcaag ctgttcacaa gattgcctga taagaatatg gaagctgtat      780

ataaagtcaa catctttaga aactcaggat gacgataaca taagactgaa agaaaatact      840

tttaccatag aaaatgaaag tgttaaaata gcatttgctg ttactctgga gacagtgcta      900

gccggtcatg aaaactgggt aaatgcagtt cactggcaac ctgtgtttta caaagatggt      960

gtcctacagc agccagtgag attattatct gcttccatgg ataaaaccat gattctctgg     1020

gctccagatg aagagtcagg agtttggcta gaacaggttc gagtaggtga agtaggtggg     1080

aatactttgg gattttatga ttgccagttc aatgaagatg gctccatgat cattgctcat     1140

gctttccacg gagcgttgca cctttggaaa cagaatacag ttaacccaag agagtggact     1200

ccagagattg tcatttcagg acactttgat ggtgtccaag acctagtctg ggatccagaa     1260

ggagaattta ttatcactgt tggtactgat cagacaacta gactttttgc tccatggaag     1320

agaaaagacc aatcacaggt gacttggcat gaaattgcaa ggcctcagat acatgggtat     1380

gacctgaaat gtttggcaat gattaatcgg tttcagtttg tatctggagc agatgaaaaa     1440

gttcttcggg ttttttctgc acctcggaat tttgtggaaa atttttgtgc cattacagga     1500

caatcactga atcatgtgct ctgtaatcaa gatagtgatc ttccagaagg agccactgtc     1560

cctgcattgg gattatcaaa taaagctgtc tttcagggag atatagcttc tcagccttct     1620

gatgaagagg agctgttaac tagtactggt tttgagtatc agcaggtggc ctttcagccc     1680

tccatactta ctgagcctcc cactgaggat catcttctgc agaatacttt gtggcctgaa     1740

gttcaaaaac tatatgggca cggttatgaa atattttgtg ttacttgtaa cagttcaaag     1800

actctgcttg cctcagcttg taaggcagct aagaaagagc atgcagctat cattctttgg     1860

aacactacat cttggaaaca ggtgcagaat ttagttttcc acagtttgac agtcacgcag     1920

atggccttct cacctaatga gaagttctta ctagctgttt ccagagatcg aacctggtca     1980

ttgtggaaaa agcaggatac aatctcacct gagttcgagc cagtttttag tctttttgcc     2040

ttcaccaaca aaattacttc tgtgcacagt agaattattt ggtcttgtga ttggagtcct     2100

gacagcaagt atttcttcac tgggagtcga gacaaaaagg tggttgtctg gggtgagtgc     2160

gactccactg atgactgtat tgagcacaac attggcccct gctcctcagt cctggacgtg     2220

ggtggggctg tgacagctgt cagcgtctgc ccagtgctcc acccttctca acgatacgtg     2280

gttgcagtag gattggagtg tggaaagatt tgcttatata cctggaaaaa gactgatcaa     2340

gttccagaaa taaatgactg gacccactgt gtagaaacaa gtcaaagcca aagtcataca     2400

ctggctatca gaaaattatg ctggaagaat tgcagtggaa aaactgaaca gaaggaagca     2460

gaaggtgctg agtggttaca ctttgcaagc tgtggtgaag atcacactgt gaagatacac     2520

agagtcaata aatgtgcact gtaatggact taataactac atgcttgcag tcactggtat     2580

cttaaaatat tatcatgtaa acaggtcatc tttaccttca taactgaatt gagtttctgg     2640

gttttttttt tttttgagat ggagtcttgc tttgtcacaa cctccacctc ccaggttcaa     2700

gcgattctct ttcttcagcc tcctgagtag ctgggactag aggcacacca ccaattccgg     2760

ctaatttttg tatttttagt agagactggg tttcaccgtt ggccaggcgg gtctcaaact     2820

cctcgtctca ggtgatctgc ttgcctcggc ctcccaaagt gctgggatta caggcgtgag     2880

ccactgcgcc cagcctgagt ttcatttttt aagtcacata gcagtagtcc ttatttcagt     2940

gctagaccct ttgaaatgcg atgaaagcta tatggaccct tcgctttgtt atataacata     3000

tgcacacata cccagaattt tgcacatatg ttcagagatt cctagacctg cagacctgcc     3060

tctgtgtgtc ccaatttaag aacctctgtt ctttcttcat gactggattt gcccaatttt     3120

gtgttatttt gggacttaat ttgtccctct ttgggacatt tccttattta ttgccctctt     3180

cagagagtag atgtagaaaa taaagagagg aaacctagat tacttaattt tattttaaca     3240

ttttctatag atagcatacc acgccaagtg tgctctgtct tgatcccctt ctttctagca     3300

tctgccagac attgtagagt ttcgcaagca gttgtaggtt tgagctgcag ccagtcattt     3360

cttttattct ttaaaagtac atagatttgt ctttttaggg ctttactgaa agtaaaatat     3420

cctgacattt aaactgacag atgtaggagg taaaaaatag agttctgaaa catttgaatt     3480

tatgtgacag ctgaagtcac gagatgaggg atatatgtcc cccagggagg atgcagaaag     3540

aagaaaaggg tactggaaac agcatgtcag tggtgccagc tgagggctgg aggcagccag     3600

gagagttggg agcctgggtg ctgggtggag agaggttaac agggaagaca tgggaagtat     3660

tgtgaaggct ggtgtgagca ggggactact ccagccctgt tggaacatag agccatttgg     3720

cagattgaca atgcagtgac agctgtatat aataaatgtg ttgaaaggag gaaggtgagg     3780

attttcttgg tgggagttta tgctgttatt taacatattt tgcttccaaa ggggttaaga     3840

tgttttacct aaatggaggt ttctaggtca gtgctataca atatttctaa tctgtgtttt     3900

atagtgtgag ctacatatgt aattttaaaa ttttcaagta gccacataat aaaggaaaca     3960

ggtgaaattt aatgacatat ttcctttaat acggtatatc caaaatatta ttatgtcaac     4020

ctataatcag tataaaaacc tgttactgaa atattttata gggcccatct cagttcagac     4080

tagccacatt taagtgcttc atagccacat gtggctcatg gccatccata tttggacaat     4140

gtactttaga ctattgcatc tgtatactct tgtgccgtca gctggggggt ggggtgtgtg     4200

tgcgtgtata ccaaggcagt gagcatctga gctttgaacc tcaaagacca aaatgccctg     4260

cccattttcc tgcttatcag ctgaggaatc tttacccaca ttgacacatg ggcttgttct     4320

gacccaagtg catgcaggct tccagagcag attcagaggc ctaacttagt cctttagctt     4380

tcctcccagc acagaactcc caaggttatc tgcaagtagg ccttgcctag agagactgag     4440

ttttcaagtt gtcagttttc ccaaattgtc ctcaagcatc ttcctctgga atcaccttac     4500

tgtttagtaa acattcagag gacttgctac acatctgggc agtctgcatt gtaattcata     4560

tgtgtttaca catttgtgtc ttcatctgct aaagcacctt tgaaccatat tgtaattcat     4620

aatatctgaa gcaattatta tgaattgtag taattcataa tattgaagcg attcataata     4680

tctgaagcaa tccccagata cgggttaggc atggccctgc tctgagcagg atggcaaaag     4740

tggcagtccg tgacgcagcc cttgttaccc caggctatta ctaaatggtg gtggtggttt     4800

tatcttaatt aaaatgacat caccaacaat gggccctttc ctgtctgcca ggaaaagttt     4860

tctgtagtga cgcacgtgtt gtgtgtgtat gtgtgcgttt gaggctatat tactcattgc     4920

tacggcagtt caaaatgact tggaaaaaaa caatgaacgc tggtcattga tatgtatact     4980

gacatgtttg agggaagtta ctgtggtctg taacttatga aatacataaa aaatatgatg     5040

ggtggagtga cggacacatg gacagatatg aagcaagcac tgtaaaatat tagtggtagt     5100

ttttgtatgc ccatactcac ggcaccatta ttcacagtag ctaagagatg gaagcaatat     5160

gtgcccatca gtgggtgaat gatcaacaaa atgtggtata ttcatacagt ggaatattat     5220

tcagcctcta aaaggaagat acgctgacat gtgctgcaac atggatgaat cttgaggaca     5280

tgatgctaag tgaagtaagc cagtcactgg aagacaaata ctctatgctt ccatttatgt     5340

gaagtatcta gagcagtcaa atgcatagaa acaagtagaa tggtagttgc caaggactgg     5400

gggaggagga aatgaggagt tgtttaatgg gtatagtgtt tcagttttgc aagataaaaa     5460

gtcctgtgga ttggttgcac agttaagtta tgtgaatgct gtatgccaac tcaactgtac     5520

actctaaaat ggttaagatg gtaaatctta tctttatttt accacagttt tttttaaagc     5580

atggtaaaca ccatttccca ggatgtaaat cggtactaaa aaaaaagtgc tccaaagtaa     5640

gatatatttg ggaaacacag ggataactaa ggttagatag gtgttcttta ttgcaggaat     5700

tctaagagca tttaacaaat taatttacac tgggaatttt cagtgtggag ggtctggctc     5760

atagcatttc acaaacatta tacttcagag tcccaaagcc tttaaataaa atgttaatgg     5820

tagaaactcc ttaaggggtg ttcactgta                                       5849


<210> 1435
<211> 4080
<212> DNA
<213> Homo sapiens

<400> 1435
aaacggggtc acagcaggac aaggaagtag ccgatctccc agatgcggtc tcttcgctcc       60

gctccacccg caccagcagc ggcccaccca cctctcctgt aagaggaaga acgtcccgga      120

gacacttccg gccccgcccc ccgaggcgga agcggagtgc caggctactc ctcccgcagt      180

gtgggtggtt ccgaggctga ctaccctgcg gcggcgcggc tcgcagtcct tctcagcatg      240

gaccgcactt gtgaggagag gcccgctgag gatgggagcg acgaggagga cccagactcc      300

atggaagccc caacccggat ccgggacact ccggaagaca tcgtgctgga agctccggct      360

agtgggctgg cgttccatcc ggcccgtgac ctactggctg caggggacgt ggacggggac      420

gtgttcgtct tttcctactc ttgccaagag ggagaaacca aggagctctg gtcatcaggt      480

caccatctca aggcctgccg agctgtggcc ttctctgaag atgggcagaa gctcattact      540

gtctccaagg acaaagccat ccatgttcta gatgtggagc agggccaact ggaaagacgt      600

gtttccaagg ctcatggtgc ccccatcaat agtcttctgc tggtggatga gaatgttctg      660

gccactgggg atgacacagg tggtatctgt ctctgggacc agcggaagga gggcccctta      720

atggatatga ggcaacatga agagtacatc gcagacatgg ctctggatcc agccaaaaag      780

ctgctgctga cagccagcgg ggatggctgc cttggcatct tcaacattaa gaggcgtcgg      840

tttgagctgc tctcagaacc tcagtctggg gacctgacct ctgtcactct catgaaatgg      900

gggaagaagg tagcctgtgg ctccagtgaa ggtaccatct acctcttcaa ttggaatggc      960

tttggggcca caagtgaccg ctttgccctg agagctgaat ctatcgactg catggttcca     1020

gtcaccgaga gtctgctgtg tactggctcc actgatggag tcatcagggc tgtgaacatc     1080

ctaccgaacc gagtggtggg cagtgtgggc cagcacactg gggagcctgt ggaggagctg     1140

gccctctccc actgtggccg cttcctggcc agtagtggcc atgaccagcg cctcaagttt     1200

tgggacatgg cccagctgcg agctgtggtg gtggatgact accgtcggcg caaaaaaaag     1260

ggaggaccac tgcgggctct gagcagcaag acttggagca ccgatgactt cttcgcagga     1320

ctgagggaag agggagaaga ctccatggct caggaagaaa aggaggagac tggggatgac     1380

agtgactgaa ggaatgaatt gaatcttgag acgggtcctc accaggcaag agtcttgctt     1440

attgggctgc atccccagag aggatatgaa ttattttttg aaaagacagg gttttgccat     1500

cgtccaggct ggagtgcgct ggcttgatct tggctcactg cagcctcaat gtccccaggc     1560

tcagattgtc cttccacctt agcctctgga gcagctggga ctacaggtgt gcactaccac     1620

accaggccaa tttttgtttt ttttttttgg tagaaacggg tctgttttgc ccaggctggt     1680

cttcaactcc tggactcaaa tgatccacct gcctctgctt cccaaagtgc tgggattaca     1740

ggcacgagcc accacacctg gccaaaaaaa tttatatttt ttgagacaag gtctcactct     1800

gtcacccagg ctggagtaca gtgggttgat catggctcac tgcatccttg acttcctggg     1860

ctcaagtgat ccacctcagc ctgcctggta gctgagactt aacaggcatc tgccaccatg     1920

cttgactaat ttttgtgatt tttttttggt agagaccagg ggtttcacta tgttgaccaa     1980

gctggtcttg gaactcctgg gctcaagtga tcctcctgcc ttggcctccc aaaatgctgg     2040

gattacaggc atgagccact gtgcctggct ggatatgaaa tttttttttt tttttttttt     2100

gagacagggt ttcgctcttg ttgccagggc tggagtgcaa tggcgtgatc ttggctcact     2160

gcaacctccg cctcccgggt tcaagcaatt ctcctgcctc agcctcccaa gtagctggga     2220

ttacaggtgt ctgccaccat gccaggctaa tttttgtatt ttcagtagag acggggtttc     2280

tccatgctgg ccaggctggt ctcgaactcc tgacctcagg tgatccaccc gcctcagcct     2340

cccaaagtgc tgggattaca ggcaaaagcc aacacacccg gcctggatat gaatttataa     2400

taccctacag tgcaacacaa gaagatgcac tcaaagcact gatgtgagga agtacttgcc     2460

ccgtagcagc tattcactct accagtgtaa acaaactcta agctagggca agacagcaca     2520

gacacaagta tatactaacc aggggtttaa tataaataca accagcatag aaagacccaa     2580

aactatacag aaaccaaaac cagaatgcca tgtggtggag gcaaagggca gaatttctga     2640

cccctttggc tcagctgccc ttccccacaa ataaaaacca acaaagagga caaatcagga     2700

caataaagaa gattcatgct aagctgtggc agagggggga aggtatgatc gggtgggggt     2760

gggacaagga acggccatgg aagatcactg ggtcaggttg gaccctgggc tgggagcggg     2820

agggcaaggc ccctcaccac aacttaaccc aaacctaagc tgcccccagg tgccataggt     2880

ccctgtccca gcagggaggc tgatgggcct gggcccatgc ccctccccac ctttgggggt     2940

cagaaagtgg ccacccaggc ctgctgggat ggggcctgac acaggctctg catgcccatt     3000

cagggtgcct gtggagaaag aatggagtca ctgtttaacc atggtacctg cctcagcccc     3060

agcagaccac aggaggttgg ccccagactc actgagtgcc tgcagcagcc gtacagacac     3120

agcatccttg gccacctcat gcccatcccg gccatctagg gtcagcacaa cccagatgag     3180

gccgctgaag ggcaccggat gcccaggaat caccacctgg taccagaagc ggtgccagcc     3240

agcaggtcct atgcccaaac acttggtgag gaacacaggg ctgcccagct tcattcgttg     3300

gcacagcaac tgcagggtag cccgagcccc ttggaaccct aacttgtccc ttgccaaagc     3360

caactggctg ccctctggct gtggggaccg caagaaggga cccacaagct gctggcgaag     3420

tcgctgcttc aggtctggct tgagccactc cacagccacc tgctctccac agaggtgtga     3480

ctgccctgta ggaaaaatgc aaagacaagg gcaggtctaa accctgggcc caagcctcca     3540

ggtggtgagc cctttggagc tacacagtcc tgttatttgt agccttccca tttcctggta     3600

gtgtgaccat gggtaagaaa agacaatgaa gccttcagcc tccattattt gcaaagggag     3660

tataacacac tgctacctta caagtttcct tggagaagta ctggttaatt gcaggctttg     3720

tctgcctcat aaccatcata atggctaatc tttactggga aaacttgctg taagtcagtc     3780

agtgtgctaa gtaccgtaca cccattatgt tacttaattc tcataacagt ctgaggaaac     3840

agattctata gtagtaaaaa gctcagttgg attcccttga gcaaatcaat ttctctaaca     3900

gtttcctcat agcttgaggg tcctgtgcct attttgcggt gtgggggtgg gggaaggttg     3960

agaattaagt caggaggtaa tgctcgggaa gtgtcacaaa tttaggtaag cggtggtggt     4020

agcaccattg gaagttttaa aaatctgaga tcaaatagta aaaggttgca aattctggca     4080


<210> 1436
<211> 1796
<212> DNA
<213> Homo sapiens

<400> 1436
aaagggcgcc acgagtcggc attgtcaggc ggcggcaccg cgcgggacgg agcttggctg       60

ttggtcggtg ggttcccgtg cggcggcggc caaggaggag gagacacagt tggagcagct      120

ccgtgggctg actggggcga ggcctcagca gcgcgagctt gagtgcggcc gagcctgcgg      180

cgccttcccc tgcgggtggg gacgagcggg ccccgcggcg tcatcggcgg cgaggagccg      240

ccgcgcctcg gcctagcatg tcggaagcgg gcgaggagca gcccatggag acgacgggcg      300

ccaccgagaa cggacatgag gccgtccccg aaggcgagtc gccggccggg gctggcacgg      360

gcgccgcggc gggggctgga ggcgcgaccg cggcgccccc gagcgggaat cagaacggcg      420

ccgagggcga ccagatcaac gccagcaaga acgaggagga cgcgggaaaa atgttcgttg      480

gtggcctgag ctgggatact agcaaaaaag atttaaaaga ctattttact aaatttggag      540

aggtcgttga ctgtacaata aaaatggatc ccaacactgg acggtcaaga gggtttgggt      600

ttatcctgtt caaagatgca gccagtgtgg agaaggtcct agaccagaag gagcacaggc      660

tggatggccg tgtcattgac cctaaaaagg ccatggctat gaagaaggac ccggtgaaga      720

aaatcttcgt tgggggtctg aatcctgaag ccactgagga aaagatcagg gagtactttg      780

gcgagtttgg ggagattgag gccattgaat tgccaatgga tccaaagttg aacaaaagac      840

gaggttttgt gtttatcacc tttaaagaag aagaacccgt gaagaaggtt ctggagaaaa      900

agttccatac tgtcagtgga agcaagtgtg agatcaaggt ggcccagccc aaagaagtct      960

atcagcagca gcagtatggc tctgggggcc gtggaaaccg caaccgaggg aaccgaggca     1020

gcggaggtgg tggtggaggt ggaggtcaga gtcagagttg gaatcagggc tacggcaact     1080

actggaacca gggctacggc taccagcagg gctacgggcc tggctatggc ggctacgact     1140

actcgcccta tggctattac ggctacggcc ccggctacga ctacagtcag ggtagtacaa     1200

actacggcaa gagccagcga cgtggtggcc atcagaataa ctacaagcca tactgaggcg     1260

gcagcaggag cgaccaactg atcgcacaca tgctttgttt ggatatggag tgaacacaat     1320

tatgtaccaa atttaacttg gcaaactttc tattgcctgt cccatgtgca tcttatttaa     1380

aatttccccc atggaaatca ctctcctgtt gactatttcc agagctctag gtgtttaggc     1440

agcgtgtggt gtctgagagg ccatagcgcc atcatgggct gatttttatt accaggtccc     1500

ccagaagcag gtgggaggct ctgcttcctg ctgccgctct gcagcctgga cctgtggacc     1560

ctggttgtaa agagtaaatt gtatcttagg aaaccagtgt cacctttttt tcacctttta     1620

attttatatt atttgcgtca tacatttcct gtaacggaag tgttaatttt actgtacttt     1680

ttggtacctt ttgggaatct aatgtattgt aaggtatttt acacgtgtcc tgattttgcc     1740

acaacctgga tattgaagct atccaagctt ttgaaataaa atttaaaaac ccccaa         1796


<210> 1437
<211> 4371
<212> DNA
<213> Homo sapiens

<400> 1437
ggcggcgcag ttgcgagtgc aggtgagttc cgggccgcca ccggctgctt ctgtgggccg       60

ggcctctgag cattggcgac cccagcccgg ctccgggctg acagggcctg gcttcgccag      120

gctccttgcc agaggcctcc actcactcca gacccctata gcccgtcgct gtcagctgtc      180

aacaaaggat gcgaatgctg gccgcttcct gtgggcttcg tgtcacccag aggtgagccc      240

aggccaggat gggggactcc agggaccttt gccctcacct tgactccata ggagaggtga      300

ccaaagagga cttgctgctc aaatctaagg gaacctgtca gtcgtgtggg gtcaccggac      360

caaacctatg ggcctgtctg caggttgcct gcccctatgt tggctgcgga gaatcctttg      420

ctgaccacag caccattcat gcacaggcaa aaaagcacaa cttgaccgtg aacctgacca      480

cgttccgact gtggtgttac gcctgtgaga aggaggtatt cctggagcag cggctggcag      540

cccctctgct gggctcctct tccaagttct ctgaacagga ctccccgcca ccctcccacc      600

ctctgaaagc tgttcctatt gctgtggctg atgaaggaga gtctgagtca gaggacgatg      660

acctgaaacc tcgaggcctc acgggcatga agaacctcgg gaactcctgc tacatgaacg      720

ctgccctgca ggccctgtcc aattgcccgc cgctgactca gttcttcttg gagtgtggcg      780

gcctggtgcg cacagataag aagccagccc tgtgcaagag ctaccagaag ctggtctctg      840

aggtctggca taagaaacgg ccaagctacg tggtccccac cagtctgtct catgggatca      900

agttggtcaa cccaatgttc cgaggctatg cccagcagga cacccaagag ttccttcgct      960

gcctgatgga ccagctgcac gaggagctca aggagccggt ggtggccacg gtggcgctga     1020

cggaggctcg ggactcagat tcgagtgaca cggatgagaa acgggagggt gaccggagcc     1080

catcagaaga tgagttcttg tcctgtgact cgagcagtga ccggggtgag ggtgacgggc     1140

aggggcgtgg cgggggcagc tcgcaggccg agacggagct gctgatccca gatgaggcgg     1200

gccgagccat ctctgagaag gagcggatga aggaccgcaa gttctcctgg ggccagcagc     1260

gtacaaactc ggagcaagtg gacgaggacg ctgatgtgga cactgccatg gctgcccttg     1320

acgaccagcc cgcggaggcc cagcccccgt caccacggtc ctccagcccc tgccggacgc     1380

cagagccgga caatgatgct cacctacgca gctcctctcg cccctgcagc cccgtccacc     1440

accacgaggg ccatgccaag ctgtctagca gcccccctcg tgcaagcccc gtgaggatgg     1500

caccgtcgta cgtgctcaag aaagcccagg tattgagtgc tggcagccgg aggcggaagg     1560

agcagcgcta ccgcagcgtc atctcagaca tctttgacgg ctccattctc agccttgtgc     1620

agtgtctcac ctgtgaccgg gtatccacca cagtggaaac gttccaggac ttatcactgc     1680

ccattcctgg aaaggaggac ctggccaagc tccattcagc catctaccag aatgtgccgg     1740

ccaagccagg cgcctgtggg gacagctatg ccgcccaggg ctggctggcc ttcattgtgg     1800

agtacatccg acggtttgtg gtatcctgta cccccagctg gttttggggg cctgtcgtca     1860

ccctggaaga ctgccttgct gccttctttg ccgctgatga gttaaagggt gacaacatgt     1920

acagctgtga gcggtgtaag aagctgcgga acggagtgaa gtactgcaaa gtcctgcggt     1980

tgcccgagat cctgtgcatt cacctaaagc gctttcggca cgaggtgatg tactcattca     2040

agatcaacag ccacgtctcc ttccccctcg aggggctcga cctgcgcccc ttccttgcca     2100

aggagtgcac atcccagatc accacctacg acctcctctc ggtcatctgc caccacggca     2160

cggcaggcag tgggcactac atcgcctact gccagaacgt gatcaatggg cagtggtacg     2220

agtttgatga ccagtacgtc acagaagtcc acgagacggt ggtgcagaac gccgagggct     2280

acgtactctt ctacaggaag agcagcgagg aggccatgcg ggagcgacag caggtggtgt     2340

ccctggccgc catgcgggag cccagcctgc tgcggttcta cgtgtcccgc gagtggctca     2400

acaagttcaa caccttcgcg gagccaggcc ccatcaccaa ccagaccttc ctctgctccc     2460

acggaggcat cccgccccac aaataccact acatcgacga cctggtggtc atcctgcccc     2520

agaacgtctg ggagcacctg tacaacagat tcgggggtgg ccccgccgtg aaccacctgt     2580

acgtgtgctc catctgccag gtggagatcg aggcactggc caagcgcagg aggatcgaga     2640

tcgacacctt catcaagttg aacaaggcct tccaggccga ggagtcgccg ggcgtcatct     2700

actgcatcag catgcagtgg ttccgggagt gggaggcgtt cgtcaagggg aaggacaacg     2760

agccccccgg gcccattgac aacagcagga ttgcacaggt caaaggaagc ggccatgtcc     2820

agctgaagca gggagctgac tacgggcaga tttcggagga gacctggacc tacctgaaca     2880

gcctgtatgg aggtggcccc gagattgcca tccgccagag tgtggcgcag ccgctgggcc     2940

cagagaacct gcacggggag cagaagatcg aagccgagac gcgggccgtg tgatctgctg     3000

ggctagtctc cccatgtgcc ccaccccgcg gaaggcgtgt ttgtgcccag aagagaggcc     3060

gggctgctgc agaaccccgc cgtgtaaaga ggcagaaaag ttggtttggt ttgcagtaac     3120

gctgcaacta gaaaatatat gcacttcagg cttgttgaaa cgaccaagac tctgtgacgt     3180

taatttgggt ctttgtcctg gcagtgcctc tgccagtcac tgtcatcgtt gtgtccccca     3240

caactgtcct cttgctagct cggcccagct ttgtccctgg agcccgatgc tacccctgtc     3300

agacagaggc tgcggcctgg gccagagtca gggagtagct gctgcttcac ggcgtctcca     3360

ctgtgcgatt ggcccggagc cccgaagact cggagggagc tgctcagggc cggtgagcgc     3420

agccagaagc cctggccagt gaggagctca caggtcctcc ctggtggtcc cgccgcacct     3480

ctgcatctcc tgggcgtcac caggaaggct ctgaagtccc gggctgctct cagcacttct     3540

cctgcagact gaagactctg gactcattgc tgattggaac accaggagga ggttggattt     3600

ctgccagtgg gggatgtttc tggaggcagc tggtccccca caccgcgtcc tgctgagcct     3660

gccccctgga ttggctgtaa tttgcctcga agttcagcag ttcatcttca tgggaaattt     3720

gctgagcccc caccagggaa ccggatgatg aaacagggat acctcacagc ttggccattt     3780

gaggcaaagg cagcttcccg agctgatgct aaagaagaca gactttccct tcctcccagc     3840

agcagcagtg cagagcccac ctggagggat gtgggggctg tgcagggtgc agcgctcagg     3900

tggatcctgg gaagcagcct ctggatgctg agtggaggga gccactgagc acagcaaggc     3960

accaaagccc ctggagaaac cgccagggcg aggtgcgacc atcatcagga tcaaagcaga     4020

cggggcgtgg gtggggaagg ggctctggga ccagaccccc cacactactg cgtctttgtt     4080

tctatcagtc tttgtagaag caggtggtgg tggaaattcc agcaggtggg tcccgcagag     4140

gccctgaggc ctcacttttc ggatcttctg tcccagatcc tgctccctcc ctgctgagcc     4200

tggggttccc ctggcattgg ccccagcctt ctgaaagccg gcgctgcagc cagaggccgc     4260

acgctgcact gtcgcgacgc agagaggctt ctgtgcaggc tgggatcggg ccccatgtct     4320

gtgctgtcta gtttgtgttc aaaatgtcag aataaacaca gaataaatgt t              4371


<210> 1438
<211> 2983
<212> DNA
<213> Homo sapiens

<400> 1438
agtatggccg ggctatggcg gcgagcactg gctacgtgcg actgtgggga gcggcgcggt       60

gctgggtgct gcggcggccg atgctggccg ccgccggggg gcgggttccc actgcagcag      120

gagcgtggtt gctccgaggc cagcggacct gcgacgcctc tcctccttgg gcactgtggg      180

gccgaggccc ggcaattggg ggcagcgcgg gcgccgggga aggcccggtc ataacggcgc      240

tcacgcccat gacgatcccc gatgtgtttc cgcacctgcc gctcatcgcc atcacccgca      300

acccggtgtt cccgcgcttt atcaagatta tcgaggttaa aaataagaag ttggttgagc      360

tgctgagaag gaaagttcgt ctcgcccagc cttatgtcgg cgtctttcta aagagagatg      420

acagcaatga gtcggatgtg gtcgagagcc tggatgaaat ctaccacacg gggacgtttg      480

cccagatcca tgagatgcag gaccttgggg acaagctgcg catgatcgtc atgggacaca      540

gaagagtcca tatcagcaga cagctggagg tggagcccga ggagccggag gcggagaaca      600

agcacaagcc ccgcaggaag tcaaagcggg gcaagaagga ggcggaggac gagctgagcg      660

ccaggcaccc ggcggagctg gcgatggagc ccacccctga gctcccggct gaggtgctca      720

tggtggaggt agagaacgtt gtccacgagg acttccaggt cacggaggag gtgaaagccc      780

tgactgcaga gatcgtgaag accatccggg acatcattgc cttgaaccct ctctacaggg      840

agtcagtgct gcagatgatg caggctggcc agcgggtggt ggacaacccc atctacctga      900

gcgacatggg cgccgcgctc accggggccg agtcccatga gctgcaggac gtcctggaag      960

agaccaatat tcctaagcgg ctgtacaagg ccctctccct gctgaagaag gaatttgaac     1020

tgagcaagct gcagcagcgc ctggggcggg aggtggagga gaagatcaag cagacccacc     1080

gtaagtacct gctgcaggag cagctaaaga tcatcaagaa ggagctgggc ctggagaagg     1140

acgacaagga tgccatcgag gagaagttcc gggagcgcct gaaggagctc gtggtcccca     1200

agcacgtcat ggatgttgtg gacgaggagc tgagcaagct gggcctgctg gacaaccact     1260

cctcggagtt caatgtcacc cgcaactacc tagactggct cacgtccatc ccttggggca     1320

agtacagcaa cgagaacctg gacctggcgc gggcacaggc agtgctggag gaagaccact     1380

acggcatgga ggacgtcaag aaacgcatcc tggagttcat tgccgttagc cagctccgcg     1440

gctccaccca gggcaagatc ctctgcttct atggcccccc tggcgtgggt aagaccagca     1500

ttgctcgctc catcgcccgc gccctgaacc gagagtactt ccgcttcagc gtcgggggca     1560

tgactgacgt ggctgagatc aagggccaca ggcggaccta cgtgggcgcc atgcccggga     1620

agatcatcca gtgtttgaag aagaccaaga cggagaaccc cctgatcctc atcgacgagg     1680

tggacaagat cggccgaggc taccaggggg acccgtcgtc ggcactgctg gagctgctgg     1740

acccagagca gaatgccaac ttcctggacc actacctgga cgtgcccgtg gacttgtcca     1800

aggtgctgtt catctgcacg gccaacgtca cggacaccat ccccgagccg ctgcgagacc     1860

gtatggagat gatcaacgtg tcgggctacg tggcccagga gaagctggcc attgcggagc     1920

gctacctggt gccccaggct cgcgccctgt gtggcttgga tgagagcaag gccaagctgt     1980

catcggacgt gctgacgctg ctcatcaagc agtactgccg cgagagcggt gtccgcaacc     2040

tgcagaagca agtggagaag gtgttacgga aatcggccta caagattgtc agcggcgagg     2100

ccgagtccgt ggaggtgacg cccgagaacc tgcaggactt cgtggggaag cccgtgttca     2160

ccgtggagcg catgtatgac gtgacaccgc ccggcgtggt catggggctg gcctggaccg     2220

caatgggagg ctccacgctg tttgtggaga catccctgag acggccacag gacaaggatg     2280

ccaagggtga caaggatggc agcctggagg tgacaggcca gctgggggag gtgatgaagg     2340

agagcgcccg catagcctac accttcgcca gagccttcct catgcagcac gcccccgcca     2400

atgactacct ggtgacctca cacatccacc tgcatgtgcc cgagggcgcc acccccaagg     2460

acggcccaag cgcaggctgc accatcgtca cggccctgct gtccctggcc atgggcaggc     2520

ctgtccggca gaatctggcc atgactggcg aagtctccct cacgggcaag atcctgcctg     2580

ttggtggcat caaggagaag accattgcgg ccaagcgcgc aggggtgacg tgcatcgtcc     2640

tgccagccga gaacaagaag gacttctacg acctggcagc cttcatcacc gagggcctgg     2700

aggtgcactt cgtggaacac taccgggaga tcttcgacat cgccttcccg gacgagcagg     2760

cagaggcgct ggccgtggaa cggtgacggc caccccggga ctgcaggcgg cggatgtcag     2820

gccctgtctg ggccagaact gagcgctgtg gggagcgcgc ccggacctgg cagtggagcc     2880

accgagcgag cagctcggtc cagtgaccca gatcccaggg acctcagtcg gcttaatcag     2940

agtgtggcat agaagctatt taatgattaa agtcatttgc agt                       2983


<210> 1439
<211> 1044
<212> DNA
<213> Homo sapiens

<400> 1439
aagctgggca gcctctgccg ggttccggga aaaggagctc ctgctgccac tgctcttccg       60

gagcctgcag catggggccc ctgccgcgca ccgtggagct cttctatgac gtgctgtccc      120

cctactcctg gctgggcttc gagatcctgt gccggtatca gaatatctgg aacatcaacc      180

tgcagttgcg gcccagcctc ataacaggga tcatgaaaga cagtggaaac aagcctccag      240

gtctgcttcc ccgcaaagga ctatacatgg caaatgactt aaagctcctg agacaccatc      300

tccagattcc catccacttc cccaaggatt tcttgtctgt gatgcttgaa aaaggaagtt      360

tgtctgccat gcgtttcctc accgccgtga acttggagca tccagagatg ctggagaaag      420

cgtcccggga gctgtggatg cgcgtctggt caaggaatga agacatcacc gagccgcaga      480

gcatcctggc ggctgcagag aaggctggta tgtctgcaga acaagcccag ggacttctgg      540

aaaagatcgc aacgccaaag gtgaagaacc agctcaagga gaccactgag gcagcctgca      600

gatacggagc ctttgggctg cccatcaccg tggcccatgt ggatggccaa acccacatgt      660

tatttggctc tgaccggatg gagctgctgg cgcacctgct gggagagaag tggatgggcc      720

ctatacctcc agccgtgaat gccagacttt aagattgccc ggaggaagca aactcttcgt      780

ataaaaaaag caggccatct gcttaaccct tggctccacc ataaggcact gggactcgga      840

tttctctatc tgatagaggt attttctgtg gccctgggag ctgtctgtct ttcccctacc      900

cccaaggatg ccaggaagac gtccaccatt agccatgtgg caacctttac ttctatgcct      960

cacaagtgcc tttcagagag ccccaattct gctttcccac aaaataaacc taatgccatc     1020

aggcaaaaca tttctgtgtc tgta                                            1044


<210> 1440
<211> 4753
<212> DNA
<213> Homo sapiens

<400> 1440
cagactgctg cctccatcag tgcctgtggc gtgtgtgtgt gtgtgtgtgt gtgcgcgcgc       60

gtgcgtgcac gtgtgtatgt gtgtgtgtgt gtattgggtt tctctctccc ttgtaagaac      120

acagccagcc cgccctctcc tgctgttgct gcagctctga cttgcttttt cctgcctcct      180

tcctctcctc tctcttcttg cttagcttct tgccttctga tactactccc aagatggagg      240

ctaatcactc tgaacagctc tcagcggaac gacagtcaac acctccaggt gacagttcat      300

cattacccag tcacaatggc ctggagaagg aagatggcca ggattctcca accccagtcc      360

aaccaccaga gaaagaggca agtgtgcacc ccgatatctc tgaagagctg aatcgacagc      420

tggaagacat cattaacact tatgggtctg ctgccagcac agcagggaaa gagggctctg      480

ccagggccag tgagcagcct gagaatgcag aatcacctga caacgaggat ggggactgtg      540

aggaaacaac tgaagaggct ggaagagaac ccgttgcttc tggagagcca cccactgtca      600

aagagcccgt cagcaataag gagcaaaaat tggaaaagaa aatcctaaaa ggattaggca      660

aagaagccaa cctgctaatg caaaatctga acaagttgca aacaccggaa gaaaagtttg      720

attttttatt caagaagtat gctgaattgc tggatgaaca tcgtactgag caaaagaagt      780

taaagctcct ccaaaagaaa caggtacaaa ttcaaaaaga aaaggaccag ttacaaggtg      840

aacacagcag agctatcctc gctcgaagca aattggagag tctgtgccgg gagctgcaga      900

gacacaacaa gactctgaag gaagaggcgc ttcagcgggc acgtgaggaa gaagagaaaa      960

ggaaggaaat cacaagccat ttccagagta ccctcacgga catccagggc cagatcgagc     1020

agcagagtga gcgaaatatg aagctctgtc aggagaacac agagcttgca gaaaagctga     1080

aaagcatcat cgatcagtat gagctcagag aggagcatct ggacaaaata tttaaacaca     1140

gagaactgca gcagaagctg gtggatgcaa agcttgagca ggcccaagaa atgatgaagg     1200

aagcggagga gcgacacaaa cgagaaaagg aatatttgct gaaccaggca gcagagtgga     1260

aacttcaggc gaaagtgctg aaggagcaag agacagtcct gcaggctcag ctcactctct     1320

actcaggaag gtttgaagaa ttccagagca cactaactaa aagcaacgag gtgtttgcca     1380

cgttcaaaca ggaaatggac aaaacaacta agaaaatgaa gaagctggaa aaggacacag     1440

ccacatggaa agcccgattt gagaactgta acaaagctct gttggacatg attgaagaga     1500

aagcactgag agctaaagaa tatgagtgct ttgtgatgaa aatcgggagg ctagagaacc     1560

tctgccgtgc tttacaagaa gagagaaacg aactccacaa aaaaatcaga gacgcagaaa     1620

tatctgaaaa ggatgaccaa agtcagcaca actccgatga agagccagag tcaaacgtct     1680

ctgtggatca agagattgac gcagaggagg ttaatagtgt ccaaaccgcc gtgaaaaatc     1740

tggccacagc cttcatgata attcatcatc cagagtcaac cccgcaccag tccaaagaaa     1800

cccaacccga aataggcagt tctcaggaga gtgctgacgc cgctctcaag gagccagagc     1860

aaccccctct gatcccttca cgggattcag agagtcccct gcctccccta actcctcagg     1920

ctgaagccga aggaggcagt gatgctgaac ctccctccaa ggccagtaat tctcctgccg     1980

ggttgggagc agaaacccaa tgcgagggtc tccctgttgg agcacaggct gatcaggcgt     2040

cctggaagcc agaggcagaa gcttccggtc aggccccaca ggctcccacc gaggcctccc     2100

tacagaagat ggaggcagat gtgcctgctc cagcatgcgc agcagaagag cacgttgcag     2160

ccatggtgcc tgcatgcgag cccagtaggc agcccccacg agcagcagca gaggagctgc     2220

cagtaggggc ctcagctggg ccccagccgc gcaacgtggc tgacaccaat ctggaaggcg     2280

tcgactaagc ctcaccgtgc cttcagaggc ttcttcctgc ctctttgcat attcagcata     2340

acagcttgtc ttccgaaaaa ggcattaagg gctagagatg tcaaatggaa gagacttagg     2400

atcaagacat tttttaatgt taggcagaac acattcattc agactttgct atttgttgtc     2460

aatttatagc tgatttgaag gttttctatt taacactggt tgacagtata attttcccaa     2520

agggcaacaa aacatacaga tagcaaattt atattccttt tctgttaaga taatacttaa     2580

atttgttaat caccagtaag atttgatgtt taaagacttc cactgcaata tataaatact     2640

gaaaatgtga tgttctgctt atttggatat atagtttaac aagttccata gtaatttatg     2700

gatgcccagg ttacatttaa actatacata tacataatat atacatacgt gtgtacttat     2760

tatatgtata tatacacgta tgtatagatg tgtgaatatt tgtttatata catatatgca     2820

cgtatctata tgtatatata aatgcattat tacacataca tttctctcac cccttaatgc     2880

atttttctca atgcagaata tttagatgct aatcaaaaaa atgatctctt acttgcactt     2940

gagactatgg ttgactaatg ctctataaat ccgaagagag ttcggactat aagtatttag     3000

gctatcatta tgttgggcaa aaataagtaa cccaatggta gataaatgaa ttcaaccagt     3060

tgatcaaatg gcagaaaagc agttagacta caatctgtgc agacagcatg gacacaaaga     3120

tgaccacaag gggcccaaaa cagaaaagag aaacacaagc tcacctcttg gagctgcttc     3180

tcctacactt ctcagcccat tgctttgcca ccccctcatg tgccagggca tcccattcca     3240

ggcttcctgc aaggaaacgg ttggaagtgg gaaaggggag ctagggattg aggggttaag     3300

ggacctcaca ctaagaaggg gctgtgcttt gatcccctgc ctcttgcact accaatgtct     3360

caagacataa tattcatctc ttgctgtcag acccattcta tattctaaaa gcttctgctc     3420

cttccttccc aatttctcct ttgtagcagg aaattacacc cagccctcat ctcaattaat     3480

gctaaataaa gctattgttt ttccaaaaca caaatctaca ctgggtctca atatcagtga     3540

tgaggcttac aaaccaacac gttttctgcc atgaggattt ctctttaggc cagaagtaca     3600

aaacaaaaaa accaatggat tttaaccaaa atgatttgaa atataggtga ggattcagga     3660

gaaggcaaaa gctagaaaca cttggggttg tcaacatgag tattacatta acattgcttg     3720

atgagaacct ctaatgatac tgacaacata aattacctag ggtaaaggat agctgcaaca     3780

atgaaacagg aaagaagaga gggagagaga ggaaagggaa ggaagaaagg aaggagggag     3840

aagggaagaa agaaacaatg tctaacccaa ccctatcttg aaagttgaac tcaagtagaa     3900

aaatggatag aaacaaaatt ctctagtact catccaggaa accattcttc aatgttgcat     3960

gtggctgttt gccaaggcac acaaagtgct tgtaggcagc aaccatatgc tacaagaatt     4020

gtaaactgca tacagtttgt ttgaagtaga cagtgaggat aataacaaag ttgctaggca     4080

ggaaaaaaaa tcaggaaaaa agcttgtcgc tatttgagaa tctgtatatt tttaaaggct     4140

taaaatatta taaccacagg gtatccagcc aaattcaaca ttactgcaag tcttagagat     4200

ttaaacattc atttgattca gagctaaata ttcaccataa tccaggaggg tctccttccc     4260

cactgcagag gcagaacgtc caagaatgga gtaagattag tcatagtaaa gtctcagtct     4320

gaatatttag caagagaaac aggcagcaga ggaacccaaa ggcagtaaat caaatattct     4380

aaaacccaaa gttcattatt ttcatccaaa agactttcac agaaacacat tactcacagc     4440

catgtatatc ttggacagag tttcagatgg aatgacttgt ctgaaatttg taaagcttaa     4500

tataggtttt gggggaatta ttttaatatt caaagaatgt tttattatag tcctttgtgt     4560

taaaatttag ccttactaat tataacaata actcataaag ttctaaattc agaaggaatg     4620

tctgttcttt atcaagtgta tgtaactatt ttttagaaat gccatctact ttctagaaac     4680

actaaagtta ttgttttcta agttaaataa ctataattta tatatctatt aaaaaggtac     4740

ttctcttccc aaa                                                        4753


<210> 1441
<211> 2108
<212> DNA
<213> Homo sapiens

<400> 1441
atgaacggca ccctggacca cccagaccaa ccagatcttg atgctatcaa gatgtttgtg       60

ggccaggttc caaggacctg gtctgaaaag gacttgcggg aactcttcga acagtatggt      120

gctgtgtatg aaatcaacgt cctaagggat aggagccaaa acccgcctca gagcaaaggg      180

tgctgttttg ttacatttta cacccgtaaa gctgcattag aagctcagaa tgctcttcac      240

aacatgaaag tcctcccagg gatgcatcac cctatacaga tgaaacctgc tgacagtgag      300

aagaacaatg cagtggaaga caggaagctg tttattggta tgatttccaa gaagtgcact      360

gaaaatgaca tccgagtcat gttctcttcg tttggacaga ttgaagaatg ccggatattg      420

cggggacctg atggcctgag ccgaggttgt gcatttgtga cttttacaac aagagccatg      480

gcacagacgg ctatcaaggc aatgcaccaa gcacagacca tggagggttg ctcatcaccc      540

atggtggtaa aatttgctga tacacagaag gacaaagaac agaagagaat ggcccagcag      600

ctccagcagc agatgcagca aatcagcgca gcatctgtgt ggggaaacct tgctggtcta      660

aatactcttg gaccccagta tttagcactt tatttgcagc tccttcagca gactgcctcc      720

tctgggaacc tcaacaccct gagcagcctc cacccaatgg gagggttgaa tgcaatgcag      780

ttacagaatt tggctgcact agctgctgca gctagtgcag ctcagaacac accaagtggt      840

accaatgctc tcactacatc cagcagtccc ctcagcgtgc tcactagttc agggtcctca      900

cctagctcta gcagcagtaa ttctgtcaac cccatagcct cacttggagc cctgcagaca      960

ttagctggag caacggctgg cctcaatgtt ggctctttgg caggaatggc tgctttaaat     1020

ggtggcctgg gcagcagtgg cctttccaat ggcaccggga gcaccatgga ggccctcact     1080

caggcctact cgggtatcca gcaatatgct gctgctgcgc tccccactct gtacaaccag     1140

aatcttctga cacagcagag tattggtgct gctggaagcc agaaggaagg tccagaggga     1200

gccaacctgt tcatctacca cctgccccag gagtttggtg atcaggacct gctgcagatg     1260

tttatgccct ttgggaatgt cgtgtctgcc aaggttttca tagacaagca gacaaacctg     1320

agcaagtgtt ttggttttgt aagttacgac aatcctgttt cggcccaagc tgccatccag     1380

tccatgaacg gctttcagat tggcatgaag cggcttaaag tgcagctcaa acgttcgaag     1440

aatgacagca agccctactg agcgtgctcc cctctgagac tggagtgaga gggtcttctg     1500

attcctgccg tttgttcatc gttgtgccta aagcatgtcg atgtggcgtc aagtacatcg     1560

tccaaatccc tgtctcttca gcttctctga tgcttgaact ctcacctttg accttgtgtt     1620

gacctttgat gctgatgtgt atttttatta tgtttgtttc tttcttcgtt tttttttctt     1680

tttttctttc cttttttttt ccttttgtgc tgccaaattg gttttgctag aacgactgct     1740

gaaggggaaa tatttaaact tgcatttgaa tataaaaaaa atctattttt ctagaacttc     1800

ataagataac cacttgattt tgtgattcca attctttgta attgtcttca gagcagccct     1860

actagcacat accgcgtggt gtttgtattt ctgtgaacac acagccagtc cgtttctagg     1920

ctttgtttct ctgtgtgctt agttttaaag acaactttga agtaaacaat gaaataaaag     1980

atgtcactaa aacctctgag gctcctgagc acattttgct gatacagtct gtggggcttg     2040

aggagaccgc atgtattgtt ctttcttttg tttttcttct gagttctcaa ctgcggagag     2100

cacctgaa                                                              2108


<210> 1442
<211> 10784
<212> DNA
<213> Homo sapiens

<400> 1442
gaggcggtgg cggcggaggc ggcaccgatt gctgtgtcgg ccccagtgcg gccgaagtcg       60

cggtagagcg tagccccacg cccctccccc gtccgcgccc tccctctttc cctggggatg      120

gagaaggcga cggttccggt ggcggcggcg acggctgcag aaggagaagg gagccccccg      180

gcggtggcgg ctgtggcggg cccccccgcg gcggcggagg tcggcggcgg cgttggcggc      240

agcagcagag ctcgctcggc ctcgtctcct cgtgggatgg tgcgagtctg cgacctgctc      300

ctgaagaaga agccgccgca gcagcagcac cacaaggcca agcgtaaccg gacttgccga      360

ccccccagca gcagcgaaag cagcagcgac agcgacaaca gcggcggcgg tggaggcggc      420

ggtggaggcg gaggtggcgg cggcggcacc agcagtaaca acagcgagga agaagaggac      480

gacgacgacg aggaagagga ggtttctgag gtggagtctt tcattttgga tcaggatgat      540

ttggaaaatc caatgctgga aacagcttcc aagttgctct tatcaggtac tgctgatggt      600

gcagacctca ggacagtaga tccagaaaca caggctagac tggaagcttt actagaagct      660

gcaggaatag gaaaattgtc cacggctgat ggtaaagcct ttgcagatcc tgaagtactt      720

cggaggttga catcgtctgt tagttgtgcg ttggatgaag ctgctgctgc acttacccgt      780

atgagagctg aaagcacagc aaatgcaggg cagtcggaca accgcagttt ggcagaagcc      840

tgttcagaag gagatgtaaa tgctgtgcga aagttactca ttgaagggcg aagtgtaaat      900

gaacacacag aggaagggga gagcctcctt tgtttagctt gttctgctgg atactatgag      960

cttgcacagg ttttgttggc aatgcatgca aatgtggaag ataggggaat caaaggtgac     1020

attacacctt taatggctgc tgctaatgga ggacatgtca aaattgtgaa gttgctgcta     1080

gctcataaag cagatgttaa tgcacagtct tcaacaggca atacagcact tacatatgct     1140

tgtgctggag gctatgtaga tgttgtaaag gtgctcttgg aatccggtgc tagtattgag     1200

gaccataatg aaaatggtca tacccctctt atggaagctg gaagtgctgg acatgtggaa     1260

gtagccagat tgctgctaga aaatggggct ggcattaata cgcattctaa tgaatttaaa     1320

gagagtgccc ttaccttagc ttgttacaaa ggacacttag agatggtgcg atttcttttg     1380

gaagcaggcg cggatcaaga gcataaaaca gatgaaatgc acactgctct gatggaggct     1440

tgcatggatg gccatgttga agtagctagg ttacttcttg acagcggtgc ccaagtgaac     1500

atgcctgctg attcatttga gtcaccatta actttggctg catgtggtgg gcatgtggaa     1560

cttgcggctt tacttattga aagaggagct agcctggaag aggtcaatga tgaaggttat     1620

acaccattga tggaagcagc tcgagaagga catgaagaaa tggtggcatt acttcttggt     1680

caaggagcaa atatcaatgc acagacagaa gaaactcaag aaactgcctt gactctggct     1740

tgctgtggag gctttctgga agtggcagac tttctaatta aggcaggagc cgatatagaa     1800

ctagggtgtt ctaccccttt aatggaagct gctcaagagg gtcatttgga gttagttaaa     1860

tacttattag ctgcaggagc taacgttcat gcaacaacag caacagggga tacagcacta     1920

acatatgcct gtgaaaatgg tcatactgat gtagcagatg tcttacttca ggcaggcgca     1980

gatctggaac atgaatctga aggtggaaga actcctttaa tgaaagctgc aagagctggt     2040

catgtttgta ctgttcagtt cttaattagt aaaggagcga atgtgaatag aaccacagct     2100

aataatgacc atactgtact gtccctggct tgtgcagggg gtcatctggc agtggtggaa     2160

ctacttttgg ctcatggggc agatcctact caccgtttga aagatggctc aactatgttg     2220

atagaagcag caaaaggtgg ccatacaagt gttgtttgct atctcttgga ttatcctaat     2280

aacttgcttt cagcccctcc accagatgtc actcagttaa ctcccccatc ccacgattta     2340

aatagggctc ctcgtgtacc agttcaagca ctgcccatgg ttgttccacc tcaggagcct     2400

gacaaaccac ctgccaatgt tgccaccact cttcccatca ggaataaagc tgcttctaaa     2460

caaaagtcca gcagccattt gccagcaaac agccaggatg tacagggtta catcaccaat     2520

cagtctccag agagcattgt agaagaggct cagggaaagt taacagaact ggaacagagg     2580

ataaaagaag ccatagaaaa gaatgcacag ctgcagtcct tggaactggc tcatgctgac     2640

caacttacca aggagaagat cgaggagctc aacaaaacaa gggaggaaca aattcagaag     2700

aaacaaaaga ttttggagga actacagaaa gtagaacgag agttacaact gaaaactcag     2760

cagcagctaa aaaagcagta tctagaggtt aaagctcaaa gaattcaact tcagcaacag     2820

cagcaacagt cttgccaaca cctgggatta ctaactcctg ttggagttgg agagcagctt     2880

tctgagggag actatgcacg gttacagcaa gtggatcctg ttttacttaa agatgaaccc     2940

cagcagactg ctgctcagat gggttttgcg ccaatccagc ctctggcgat gcctcaagct     3000

ttgcctctgg cggcaggtcc cttgcctcca gggtccatcg caaatcttac agaactgcaa     3060

ggagtgatag ttggacagcc agtactgggc caagcacagt tggcagggct ggggcaagga     3120

attctgacag aaacacaaca agggttaatg gtagccagcc ctgctcagac cctcaatgac     3180

acgctggatg acatcatggc agcagtcagt ggaagagcat ctgcaatgtc aaacactcct     3240

acccacagta ttgctgcatc catttcccaa cctcagactc caactccaag tcctatcatc     3300

tctccttcag ccatgcttcc tatctaccct gccattgata ttgatgcaca gactgagagt     3360

aatcatgaca cggcactaac acttgcctgt gctggtggcc acgaggaact ggtacaaaca     3420

ctgctagaga gaggagctag tatagagcac cgagacaaga aaggttttac tccactcatc     3480

ttggctgcca cagctggtca tgttggtgtt gtggaaatat tgctggacaa tggtgcagac     3540

attgaagccc agtctgaaag aaccaaggac acaccactct ccttggcttg ttctggggga     3600

agacaggagg tggtggagct attgttagct cgaggggcaa ataaagagca caggaatgtt     3660

tctgattaca cacctctaag tctggctgct tctggtggct atgtgaacat catcaaaata     3720

ttactaaatg caggagctga gattaactct agaactggta gcaaattggg catctctcct     3780

ctgatgttag cagctatgaa tgggcataca gctgctgtta agctcctgtt agacatgggc     3840

tctgacataa atgctcagat agaaaccaat cggaacactg cccttacttt agcctgcttc     3900

caaggaagaa ctgaagtggt tagtcttctg cttgatagaa aagcaaatgt tgaacacaga     3960

gctaagactg gtctcacacc actaatggaa gctgcctctg gtggatatgc ggaggtgggc     4020

cgagttcttt tggataaagg tgctgatgtt aatgcccctc cagttccctc ctcaagagat     4080

acagctttaa ccatagcagc agataaaggg cattacaaat tctgtgagct tcttattggc     4140

aggggagctc atattgatgt acgtaacaag aaggggaaca ctccattgtg gctagcagca     4200

aatggtggac acctcgatgt ggttcagtta ctggtgcaag caggtgcaga tgtggatgca     4260

gcagataacc gcaagataac tcctcttatg gcagcattta gaaagggtca tgtgaaggtg     4320

gtgcgctact tagtcaaaga agtcaatcag tttccatcag attctgaatg tatgagatac     4380

atagcaacca tcactgataa ggagatgctg aagaagtgtc atctttgtat ggagtcaata     4440

gtacaagcca aagatagaca ggctgctgaa gcaaacaaaa acgccagcat tttgttagag     4500

gagttagact tggaaaagtt aagggaagaa agtcggaggc tggctttggc tgcgaaaaga     4560

gaaaaaagaa aagagaagag aaggaagaaa aaggaagaac aaagaaggaa actagaagaa     4620

attgaagcca aaaataaaga gaactttgaa ctccaagctg ctcaagaaaa agaaaagctt     4680

aaagttgaag atgagcctga agtcttgaca gaacctccaa gtgccacaac cactactacc     4740

ataggtatat ctgcaacctg gacaactttg gcaggttctc atggtaaaag aaataatacc     4800

ataactacaa ccagttcaaa gaggaaaaac aggaaaaata aaattactcc agaaaacgtt     4860

caaattatat ttgatgatcc actaccaatt tcatacagtc agccagagaa ggtgaatgga     4920

gagtccaaga gcagcagtac cagcgagagt ggggacagtg ataacatgag gatttccagc     4980

tgcagcgatg aaagtagtaa cagcaacagc agtcgtaaga gtgacaatca ttcaccagct     5040

gtggtcacta ccactgtgag cagcaaaaag cagccatcag ttcttgttac atttccaaag     5100

gaagagagaa aatctgtttc tggcaaggct tcaataaaat tgtcagaaac tatcagtgaa     5160

gggaccagta attctctatc tacttgtaca aaatctggtc catctcccct ttcttctcca     5220

aatgggaagt taacagtagc aagtcctaag cgtgggcaaa agagggaaga aggatggaaa     5280

gaagttgtaa gaaggtcaaa gaaagtatct gttccatcaa ctgtgatatc cagagtgatt     5340

ggaagaggag gctgtaatat caatgctatt cgggagttta ctggtgcaca catagatatt     5400

gataaacaga aagacaagac tggagaccgg ataatcacta taaggggtgg cactgaatca     5460

acaagacaag caactcaatt gattaatgct ttgatcaagg atccagacaa agaaattgat     5520

gaacttattc caaagaatcg tttgaaaagc tcctcagcaa attccaaaat agggtcatca     5580

gcacctacca ccactgctgc taacacttcc ttaatgggaa ttaaaatgac aactgtagct     5640

ctgtcatcaa catctcaaac tgccacagca ctcactgtgc ctgcaatttc ttctgcatcc     5700

actcacaaaa ccattaagaa cccagtgaat aatgtgaggc ctggttttcc agtttctctt     5760

ccattagcat atcctcctcc acagtttgca catgctttgc ttgctgctca gactttccag     5820

cagatccgtc caccaaggtt gcccatgacc cactttggag gtacttttcc accagctcaa     5880

tccacttggg gtccgtttcc tgtcaggcct ttgagccctg ccagagctac taactcgcct     5940

aagcctcaca tggtgcctcg ccatagcaat cagaatagca gtggttctca ggtgaattca     6000

gcaggttctt taacttcaag cccaacaact acaaccagtt catcagcttc aacggtgcct     6060

ggtacatcta caaatggcag tccaagttca ccttctgtcc gaaggcagct ttttgtcaca     6120

gttgtgaaga catccaatgc caccacaaca acagtcacaa ccacggcaag caacaacaac     6180

actgcaccca caaatgccac atatcctatg cctactgcca aagaacacta tccagtatca     6240

tccccatctt ccccatcacc accagcccag ccaggagggg tttctagaaa cagccctttg     6300

gattgtggat cagcatctcc aaataaagtg gcatcttcct ccgaacagga agcaggtagt     6360

ccaccagtag tagaaacaac aaacactaga cctccaaaca gcagcagttc ttctgggagt     6420

tcatcagctc attctaatca gcaacaacct ccgggatctg tttctcagga accaagacca     6480

cctcttcagc agtctcaggt tcctcccccg gaagttagaa tgactgttcc tcctttagca     6540

acaagttctg ctccagtggc ggtgccttct actgccccag tgacttaccc tatgcctcag     6600

acaccaatgg gatgccccca gcctactcct aaaatggaaa cccctgctat tagaccaccc     6660

cctcatggca caactgcccc tcacaagaat tcagcttcag tgcaaaattc atctgttgca     6720

gtcctcagtg tcaatcacat taaaagacct cacagtgttc cctcttctgt ccagctacct     6780

tcgaccttaa gtacacaaag tgcttgtcag aattcagtac atccagcaaa taagcctatt     6840

gctcccaatt tcagtgcccc cttaccattt gggcccttta gcacattgtt tgaaaacagc     6900

cctacttctg ctcatgcctt ctggggagga tctgttgttt catctcagtc aacaccagaa     6960

tctatgctat caggaaaatc ctcatatttg ccaaattcag atcctttaca tcagtctgat     7020

acttccaaag ctccaggttt tagaccacca ttacagagac ctgctccaag tccctcaggt     7080

attgtcaata tggactcgcc atatggttct gtaacacctt cttcaacaca tttgggaaac     7140

tttgcttcaa acatttcagg aggtcagatg tacggacctg gggcacccct tggaggagca     7200

cccgcagctg ctaactttaa cagacaacat ttttccccgc ttagtttgtt gactccgtgt     7260

tcatcagcat caaatgattc ttctgcacag tcagtatcct cgggagttcg tgcaccatct     7320

cctgccccat catcagtacc gttagggtca gaaaagccca gcaatgtgtc tcaggacagg     7380

aaagttccag tccctattgg gactgaacgt tctgcacgta tcaggcaaac tggaacgtca     7440

gctccatctg ttattgggag caatttgtct acatcagtag gacatagtgg catctggtcc     7500

tttgaaggga ttggtggcaa tcaagacaaa gtagactggt gtaaccctgg gatgggaaat     7560

cctatgatcc acagaccgat gtctgaccca ggagtatttt cacaacatca agcaatggag     7620

cgagatagta caggaattgt aactccttct ggtacattcc atcagcatgt tcctgcaggc     7680

tacatggact ttcctaaagt tgggggtatg cctttttctg tgtatgggaa tgcaatgatt     7740

cctccagtag cacctatccc tgatggtgct ggaggaccca tatttaatgg ccctcatgct     7800

gcagaccctt cttggaactc actgataaag atggtttcca gctccacgga aaataatggc     7860

cctcaaacgg tgtggactgg accctgggca cctcacatga acagtgtgca tatgaaccag     7920

cttggctgat gaggatcagc ttgttagcct gcagattcct tttcatttgg aggaaatcac     7980

aagtggccga aaaaaaaaat tatgctccca aatcattcta ctgatgtgct tgactgaagt     8040

gtgtaggctt tttgcagaag atcttactaa ctgacctatt ttctgtgaac atttgtgact     8100

gcccattccc catcatcatc cgttttacct tagttagcat ttttcttatc atttttcttt     8160

ttttctttcc ctcttcccct ttggacataa ctttctgttg aagctgttct ttggctggtt     8220

ggttttagta ctgtaaactg cttctgagca aacacggaaa tttagcaaaa ttatgtaaac     8280

ttgatcctga agttttagaa tggcaaataa atgtacaatt gtttacataa cagaaaaggc     8340

taagcagaaa gtaaatttca atatgtcagt atagaggctc tactttatgt agacttaaat     8400

taatgtgaga tatgtacctt catattcaga aatctggatg tttccttcat acattaaact     8460

attaataagc ataacttttc tactggtgta atttaagtat aaagtaaaat aatgggcatt     8520

atcattggat gtttccccac attggctttt aaaataccca tcttgctttc tttttggttt     8580

atttgtagca aggcacatat agaagaagaa atttctggct tttccatgtt gttttattac     8640

cttttctcac ttttaaaact aatacagact tatctcctca ctcctttttc tctccttacc     8700

tttaccacta ataccagtaa aattatcttt ctgatagtga aaaggttctg tcaagatttt     8760

cactgtaatg gctgctacag agatggacca tcttcatcat caccagtggt ttcttctaat     8820

tataaaatgt ttaaactttc tgagaattta aaaagccacc actgttccca gtcagcatat     8880

acaagctctt aatattctgt ttattaaata attcaatgta ctattttata ttggatgata     8940

ttgattctta acattggctt ttcagtcatc aacagtcaac ataaaaattt caattttcag     9000

taatttagtg gaaaatatct tatttctttt ttcaatttta aaggcttcct gcttttttac     9060

ccttgtatat tatcagtgaa aaggatcaac agttaatttg agccaagtaa taaaagaaat     9120

tctgcatttg tcacgaagac aatttatggt agacagataa atacacagat tacagtgtaa     9180

agtctccatt taacctgttt ataaaagata caaggccaca ctaaactact cagtgggatt     9240

tatatattcc atccacttga aacaataaac agtaatgtat ccaagaagat tatgtgtcct     9300

accctgtctc atggaaaaat taattatatg gttgaaatgt aaaagaaagt aagcataaaa     9360

atcgagtaat gtatatatca atttgtcttc ttttttttta attagacata aaatttcaca     9420

ctggtaaaac ataaaaacta actaaaattc atataaatca cctagagttg atgatattaa     9480

catggttcct tggttgtcaa gtaaatcaaa tgatttcttc catctgagta aagagtaaag     9540

cctgagtaaa gagtaaaaag atgacttctc aaacatatcc agaaatttgt aaacagtaca     9600

ctcatatctt ttagtttaag aagtggtctt aaaatatata aatttgtttt tccacctatg     9660

tttaatatgc ccaaatttaa agggagagct aaaagacagc ctacaaataa atatagctat     9720

gaaataaaat tatagcactt tactaaaaaa gggatgtaat aatgttattt aacgaagtat     9780

tttatatatg acttgccact attctataca taaaattttt tttcttaatt ctttcctgtg     9840

ttaactaggg ttattttcta tttaaggtaa tcctgctgga gaacagatgc tatccaatat     9900

ttattacaac acatgagttg tgttgtttca caatactgaa tttcttaggt gaggtatttt     9960

atttaaaaag gagggggaaa actcctatat tttcttgact tcaaacctgt ggggccaggg    10020

gatatagatt gaaatgctcc gtatttagtc ttggggatca ggcttgttta gtacaatacc    10080

atggttttag aagtctgtac taggaacatt tttaaaatac attttttata tttcagatgt    10140

aatgcagtgc acttttattt gaacaataaa aaaacccata actttttgag accatgaagg    10200

tcttttattt tttaattttg aaaatatgtg gtatgtgtat atgcagacta catcattgtt    10260

ttaagaaatg atttaactct tggacattac acttgggtta gttcacacct taaatcccca    10320

agtagttaat atctcaatta ttgtataatc agtttatacc atccattccc aacaaaattc    10380

cacatttcat gccttttcaa catacatttc aacataatca acatatttac aaacactgac    10440

ttcactgttt ataaagaaga aatttcccct cctatttccc attactgaaa agtcaagtca    10500

tttttattga tacatgaaaa ttaatttttt tgtaaatgac tacgtatagt catttttctc    10560

ctttggaaaa ggtaaatagc ttattaacta atcctgtctt gttcttcaca aaaataatag    10620

tccatccgtg ttttgactca aataacctaa atacacattt tgtaaaaatt ttgtacccta    10680

tattacttat ttttaaaaca gtacagtgtt agactaaaca ggaaaactca aagttataaa    10740

atctcttcag atcctctagt ttattaaatc tattttcatg ttga                     10784


<210> 1443
<211> 6407
<212> DNA
<213> Homo sapiens

<400> 1443
atgacggagg gccgccgatg tcaagtacat cttcttgatg acaggaagct ggaactccta       60

gtacagccca agctgttggc caaggagctt cttgaccttg tggcttctca cttcaatctg      120

aaggaaaagg agtactttgg aatagcattc acagatgaaa cgggacactt aaactggctt      180

cagctagatc gaagagtatt ggaacatgac ttccctaaaa agtcaggacc cgtggtttta      240

tacttttgtg tcaggttcta tatagaaagc atttcatacc tgaaggataa tgctaccatt      300

gagcttttct ttctgaacgc gaagtcctgc atctacaagg agcttattga cgttgacagc      360

gaagtggtgt ttgaattagc ttcctatatt ttacaggagg caaagggaga tttttctagc      420

aatgaagttg tgaggagtga cttgaagaag ctgccagccc ttcccaccca agccctgaag      480

gagcaccctt ccctggccta ctgtgaagac agagtcattg agcactacaa gaaactgaac      540

ggtcagacaa gaggtcaagc aatcgtaaac tacatgagca tcgtggagtc tctcccaacc      600

tacggggttc actattatgc agtgaaggac aagcagggca taccatggtg gctgggcctg      660

agctacaaag ggatcttcca gtatgactac catgataaag tgaagccaag aaagatattc      720

caatggagac agttggaaaa cctgtacttc agagaaaaga agttttccgt ggaagttcat      780

gacccacgca gggcttcagt gacaaggagg acgtttgggc acagcggcat tgcagtgcac      840

acgtggtatg catgtccggc attgatcaag tccatctggg ctatggccat aagccaacac      900

cagttctatc tggacagaaa gcagagtaag tccaaaatcc atgcagcacg cagcctgagt      960

gagatcgcca tcgacctgac cgagacgggg acgctgaaga cctcgaagct ggccaacatg     1020

ggtagcaagg ggaagatcat cagcggcagc agcggcagcc tgctgtcttc aggttctcag     1080

gaatcagata gctcgcagtc ggccaagaag gacatgctgg ctgccttgaa gtccaggcag     1140

gaagctctgg aggaaaccct gcgtcagagg ctggaggaac tgaagaagct gtgtctccga     1200

gaagctgagc tcacgggcaa gctgccagta gaatatcccc tggatccagg ggaggaacca     1260

cccattgttc ggagaagaat aggaacagcc ttcaaactgg atgaacagaa aatcctgccc     1320

aaaggagagg aagctgagct ggaacgcctg gaacgagagt ttgccattca gtcccagatt     1380

acggaggccg cccgccgcct agccagtgac cccaacgtca gcaaaaaact gaagaaacaa     1440

aggaaaacct cgtatctgaa tgcactgaag aaactgcagg agattgaaaa tgcaatcaat     1500

gagaaccgca tcaagtctgg gaagaaaccc acccagaggg cttcgctgat catagacgat     1560

ggaaacattg ccagtgaaga cagctccctc tcagatgccc ttgttcttga ggatgaagac     1620

tctcaggtta ccagcacaat atccccccta cattctcctc acaagggact ccctcctcgg     1680

ccaccgtcgc acaacaggcc tcctcctccc cagtccctgg agggactccg acagatgcac     1740

tatcaccgca acgactatga caagtcaccc atcaagccca aaatgtggag tgagtcctct     1800

ttagatgaac cctatgagaa ggtcaagaag cgctcctctc acagccattc cagcagccac     1860

aagcgcttcc ccagcacagg aagctgtgcg gaagccggcg gaggaagcaa ctccttgcag     1920

aacagcccca tccgcggcct cccgcactgg aactcccagt ccagcatgcc gtccacgcca     1980

gacctgcggg tccggagtcc ccactacgtc cattccacga ggtcggtgga catcagcccc     2040

acccgactgc acagcctcgc actgcacttt aggcaccgga gctccagcct ggagtcccag     2100

ggcaagctcc tgggctcgga aaacgacacc gggagccccg acttctacac cccgcggact     2160

cgtagcagca acggctcaga ccccatggac gactgctcgt cgtgcaccag ccactcgagc     2220

tcggagcact actacccggc gcagatgaac gccaactact ccacgctggc cgaggactcg     2280

ccgtccaagg cgcgccagag gcagaggcag cggcagcggg cggcgggcgc actgggctca     2340

gccagctcgg gcagcatgcc caacctggcg gcgcgcgggg gtgcgggggg cgcggggggc     2400

gcggggggcg gtgtgtacct gcacagccag agccagccca gctcgcagta ccgcatcaag     2460

gagtacccgc tgtacatcga gggcggcgcc acgcccgtgg tggtgcgcag cctggagagc     2520

gaccaggagg gccactacag cgtcaaggct cagttcaaga cgtccaactc ctacacggcg     2580

ggcggcctgt tcaaggagag ctggcgcggc ggcggcggcg acgagggcga cacgggccgc     2640

ctgacgccgt cgcgatcgca gatcctgcgg actccgtcgc tgggccgcga gggcgcccac     2700

gacaagggcg cgggccgtgc cgccgtctca gacgagctgc gccagtggta ccagcgttcc     2760

accgcctcgc acaaggagca cagccgcctg tcgcacacca gctccacctc ctcggacagc     2820

ggctcgcagt acagcacctc ctcccagagc accttcgtgg cgcacagcag ggtcaccagg     2880

atgccccaga tgtgcaaggc cacgtcagct gccttacctc aaagccagag aagctcgaca     2940

ccgtcaagtg aaattggagc caccccccca agcagccccc accacatcct aacctggcag     3000

actggagaag caacagaaaa ctcacccatt ctggatgggt ctgagtctcc acctcaccaa     3060

agtactgatg aatagaggag ctacaatgat agctgtttcc tggattcctc cctctatcca     3120

gaactagctg atgtccagtg gtacgggcag gaaaaagcca agcccgggac cctcgtgtga     3180

gccagcccgg cctaatctga ccgcctcaac gccattctga gatcacctca ctgcctctca     3240

tttgccttac ccagacgcac cgtcaccctg caccagcttt ggccctcagc actttttttc     3300

tcctgtctcc gcattccctc ccccttgaaa acctgactga ggagacattc tggaaggttc     3360

cggtcccact gtgtgtcccc tggcgctctt gcccatagag agccagacac caatcctcaa     3420

tggcaccttg gtggcttccc tctgccatga cagcccctag gccaggaacc atcagggggg     3480

ccagccggca tccaattcct gcggataagt agcgttggga gagaacggga aaggggactt     3540

gagttacagg gtgacccaga aagacgattc agctgtgtcc agcctgccac ccatacgtag     3600

gccaaccaag cacttcatga agaggaggcc tcgtggcata ttcagtttac acctgaaata     3660

ttccttgatg ggacagcttg tggggatggc tatgggggaa ggggaggttg agaaaggaag     3720

ttctcgacac cagaaatgca tcggaggacc acaatcagtt ctatgctgcc aaagattaaa     3780

aataaataaa aacataaaaa attaagaggg gccaagagga agacattctt tctgcaagga     3840

aatttctttt aaattctgaa ctgctactac acacaagtga aagtcaaccc tatgtaaact     3900

ggtgtcctct ctctagccct ctcccttact ggcccacttc tctctccgta gagagcctga     3960

aaaactgccc caatgccacg gtaaaggcga ggaagtcttg gctggcgttg ctgactcaca     4020

gtcgccatcc atctggacac aaagagagac ctgtgggagt cgtagagggt actgttagcc     4080

ccggtccatg cagggggttc agccgagccc aagactcaaa gctgctttcc tttcaggatt     4140

tgtagtaacg taaggtgata atggccaaaa gtggttctct ctcattaaac caaccagtaa     4200

aagcgtatcc tatttttttg cacaaggtgt ttcattttcg tttttatggg aaaccaaggg     4260

aaaagcacat tgcgatccat tcagtgttta actgtcgtgg ctcattttct gttcgttagc     4320

acttgtgtga caaaagagct cagatccgac ttctcctatg tgtcacttat tccaagaacc     4380

caactatgcc cttaggtaga aagatttgac tcgtgtgtct actagccaac aggcagagca     4440

gggttgaaaa aaatatcagc tcccaaaggg cccatgtgtc tacatcatca gttactgtca     4500

tgcaccacat ttgtgtgcag ataccaaaag aggaggaaag aagaaaaaaa ttaatgtgtg     4560

ggagctgcac gtttacatgt tttgagctat gcttcaaaca caactggaaa gccatcaatc     4620

ttcaaaggcc tcaaaaatac ttttatagta acaagtgcac gactttagtt gggttattca     4680

agatggcaca aaaaggtttc cgcagaggtg gtatgctgtg cttttggcgc aagtggtggg     4740

gggatggggt gggggtggaa tttttttctc actctaatga cttcctattg gaaaggcatt     4800

gacagccagg gacaggagcc agggtggggg tagttttgtg ggaaagcaga actgaagtta     4860

gcttaagcat aaaaacaaag aaaaatcttc gcttttcatg tatgtggaat ccaagaataa     4920

ccataggctc taccagacca gaagggtaag gatggacact aaaatgaaac aaataccaag     4980

gtattccttc tgctgcagcc tggagaccac cgagagtcga gctggggcac acacacacct     5040

ggccgggacc cggcagggac aaggcgggcc gtggcctcct ccaccaagtc tctctagaca     5100

attcagggcc tgctttcccc agctccatgc atggctggac tggtgattcc agggtgcaga     5160

agggattcat attcccagaa cgctttaagt gtacacctgc aggataaaga gataccggtt     5220

acattattaa atgattctag ggattcactg ggggatattt ttgttgcttt tactttcatg     5280

gttagagcta caaagaacag tgattttttt tttttctccc ttccccattc agaaacatta     5340

tacattgggc catttttctt tctcccaaag aagattcatg gatagtcaga ctgaactgtg     5400

tgcaacagga aaagtcaaaa gggaaaaggt agctgatgag gttacatggt tacatgttct     5460

acatcatgca tagtagcttg aaatctagtc tggagaaaac tggatcaaga ttctagccca     5520

ctggagttgc aaggaatgag aggcaaaaat tctaaagatt tgggttatat tttcaacttg     5580

ggggacagag agaaatggag agcaggaatt acagttccaa caaacatcat gatagtctgg     5640

tagtcaagac agagattaag taaaacaggt tttactgttt agctgagttc agttaataca     5700

aaatgtacat aaaacgttag tcctttgaga ctgacatgat taatgatcag tgtggtggga     5760

aatgatgtag ttattgtaca caagcacttg caaactcttt atccctattt ctttaaaaca     5820

aaataaggtg aaatacgaag tccttggtct gatataaagc ccctattgga ttcttcggat     5880

gcgtaaaaga aattgcctgt ttcagccaga agactggtga aaacacatac atcagactat     5940

gttgtgagcc aggttgattt tttattttat tatatgcagg tgagtgttga aactgttaaa     6000

attccaattt gttttcattc agtattagtt tagttctaaa tatagcaaac cccatccagg     6060

tgctatcaga tgaccagtta ctgcttagtt aactaggtgt aaagttttac atatacatta     6120

atgtcaatag tttattacaa gttgtgtaaa atggactcta gtttaataat gggggaaaaa     6180

agattaggtt gctcctgaaa ctgactgtag agcatgtaaa atgattttac tggattctgt     6240

tcaactgtaa tcaatgaaaa agatgtacgt tgtagacaaa gttgcagaat taaaaaaaga     6300

aatctgcttt taatttattc tttttgtatt aagaatttgt atagtacctt tacattttgc     6360

aaaacagtgt tgtcaacact tattaaagca ttttcaaaat gaaaaga                   6407


<210> 1444
<211> 2619
<212> DNA
<213> Homo sapiens

<400> 1444
agtccctttt tcttgagaga gtgtggctct gtcaccaagg ctggagtgca ggggcacaat       60

ctcagctcac tgcaacctcc accttgcgtg tctcagcctc ctgagcagct gggaccacag      120

gagtgtgcca ccacacccag ctaatttttg tattttttta gtagagatgg ggtgtcacca      180

tgttggccag gctggtctca aactctcggc ctcagcctcc caaagtgctg ggattatagg      240

tgtgagccac cacacccagc ctctatatcc cttttatcgg tggacccaac aatcttctgt      300

agacagaaga ctgtgtgaat aagccaatgg tcccaagaga gcacgcatcc taatgagaac      360

ggagacagat aataaagagg gaaacaagta aaccaactat caatgattag gagcgtcaga      420

tagagccagg tgcagcctgg acaacatgat gagatcccca tctctaaaaa tataaaataa      480

attagctggt catgatggtg cacacctgta gccccagctt ctcagtaggc tgaggtggga      540

ggattgctta agcctgggag gtcaagccta cagtgagcca tgatctcacc atgcactcca      600

gcctagacaa cagggcaagg ccctctaaaa aaaaaaatga aaagatagca tgctttggcc      660

ggatgtggtg gctcacgcct gtaatcccag cacttcagga ggttgaggcg ggcagatcac      720

ctgaggtcag gagtacgaga tcagcctggc caacacggtg aaaccccatc tctactaaaa      780

atacaaaatt aactgggcgt ggtggctcat gcctgtaatc ccagctactc tggaggctga      840

ggcaggagaa tcgcttgaac ccaggaggcg gaggttgtgg tgagctgaga ttgcgccatt      900

gcactccagc ctgggcaaca agagcgaaac tccgtctcaa aaaaggatag catgcttcat      960

aaacggtgaa atgacatgca aaggccatag ttgtcaagca ccagtaacac cagagagtgg     1020

cctgtctttc cttcaagcag accagagagg accgttctgc tggacgccta cagtgaacat     1080

ctggcagcgg ccctgtgcac caatccaaac ctgatagagc tgtctctgta ccgaaatgcc     1140

ctgggcagcc ggggggtgaa gctgctctgt caaggactca gacaccccaa ctgcaaactt     1200

cagaacctga gcactttggg aggcccagat ggggaggatc acttgaccca ggagttcaag     1260

accagcctgg ccaacatggt gaaaccccat ctctactaaa aataccaaaa tgagccaggc     1320

atggtggcac acgtctgtaa gcccagctac tcaggaggcc aaggcaggag gattgcttca     1380

acccaggagg cagaggttgt ggctgaagag gtgccgcatc tccagctcag cctgcgagga     1440

cctctctgca gctctcatag ccaataagaa tttgacaagg atggatctca gtggcaacgg     1500

cgttggattc ccaggcatga tgctgctttg cgagggcctg cggcatcccc agtgcaggct     1560

gcagatgatt cagttgagga agtgtcagct ggagtccggg gcttgtcagg agatggcttc     1620

tgtgctcggc accaacccac atctggttga gttggacctg acaggaaatg cactggagga     1680

tttgggcctg aggttactat gccagggact gaggcaccca gtctgcagac tacggacttt     1740

gtggctgaag atctgccgcc tcactgctgc tgcctgtgac gagctggcct caactctcag     1800

tgtgaaccag agcctgagag agctggacct gagcctgaat gagctggggg acctcggggt     1860

gctgctgctg tgtgagggcc tcaggcatcc cacgtgcaag ctccagaccc tgcggctgga     1920

tagctgtggc ctcacagcca aggcttgtga gaatctttac ttcaccctgg ggatcaacca     1980

gaccttgacc gacctttacc tgaccaacaa cgccctaggg gacacaggtg tccgactgct     2040

ttgcaagcgg ctgagccatc ctggctgcaa actccgagtc ctctggttat ttgggatgga     2100

cctgaataaa atgacccaca gtaggttggc agcgcttcga gtaacaaaac cttatttgga     2160

cattggctgc tgaatggtcc tatctgctgg ctctcccctg agatctggac agaggaagat     2220

gggagggtgc tcatcacccc cccagcataa tgatcagcct ccttcctaga gacagactca     2280

tgcagattga gatcaaaagt ccctctgctt gggatcaaat taatgtttga cagagctggc     2340

caggcgtggt ggctcatgta tgtaatccta gcacttcgag aggccgaggc aggtggatca     2400

cgaggtcagg agtttgagat tagcctggcc aagatggtga aaccctgtct ctactaaaaa     2460

taaaaaaaaa ttagccaggc atggtggcgg gcacctgtag tcccagctac tcaggaggct     2520

gaggcaggag aatcgcttga acccgggagg tggaggttgc agtgagccga gatcgcgcca     2580

ctgcactcca gcctgggcga cagagtggga ctccatctc                            2619


<210> 1445
<211> 1202
<212> DNA
<213> Homo sapiens

<400> 1445
tgggcggggt tatataagcc agcggcgggc ggaaggcggg gcgtgggggt ctgtggctgc       60

tgggctggcg gggcgcaggc cgcgggaccc gagcccgggg aagcgagaga gcggaggcgc      120

cgaggatccg attcactccc tggggagacc tatgggccga agccgtgtaa atgcgtttta      180

agcagaggcc tcggctccgc aactgccact cctcctcggg gtgttgcaca agtttcgagg      240

tcaccggcga ccccccctag cagcgcgcct ggctctggcc cccgcgaagg aggacggagt      300

ttggagcttg cggcccccac ccaccgcgtg gcgtccccag gcacgcctag aattctagca      360

cctcaggatc agtccagccc ccatttacaa ttggggaaac tgcggctccg aaagggtcag      420

agggtacccg aggtcaagca gtagagagcg gactcgaact taagctcttg ctcttaggct      480

gagacgcctt gatgtggcca ccggctaccc tctagtgtgt tgcatacttt ctaaggcggc      540

ggctgcagca gcggctccat ccagcccgtc agctcctcct gcaaggcatg gctggctacc      600

tgagtgaatc ggactttgtg atggtggagg agggcttcag tacccgagac ctgctgaagg      660

aactcactct gggggcctca caggccacca cggacgaggt agctgccttc ttcgtggctg      720

acctgggtgc catagtgagg aagcactttt gctttctgaa gtgcctgcca cgagtccggc      780

ccttttatgc tgtcaagtgc aacagcagcc caggtgtgct gaaggttctg gcccagctgg      840

ggctgggctt tagctgtgcc aacaagattg cttccgtgat caactcagcc ttggacctgt      900

acttcccaga gggctgtggc gtggacatct ttgctgagct ggggcgctac tacgtgacct      960

cggccttcac tgtggcagtc agcatcattg ccaagaagga ggttctgcta gaccagcctg     1020

gcagggagga ggaaaatggt tccacctcca agaccatcgt gtaccacctt gatgagggcg     1080

tgtatgggat cttcaactca gtcctgtttg acaacatctg ccctaccccc atcctgcaga     1140

agtctaagaa ccactcaccc tgctacatgt ctctagagtc cattcatttc attgccgtgt     1200

ag                                                                    1202


<210> 1446
<211> 1364
<212> DNA
<213> Homo sapiens

<400> 1446
gccttacgcc gctgacgcat cgcgcccaag atggcggcgc ggtcgtcgtc gggggtggcg       60

gcggcagagg gggcggcggc cctggcggca gcggagacgg cagccgtgac ggtggcagcg      120

gcggcgcggg acctgggcct gggggaatga ggcggccgcg gcgggccagc ggcggagccg      180

tgtagcggag aagctccccc tccctgcttc ccttggccga gccgggggcg cgcgcgcacg      240

cggccgtcca gagcgggctc cccacccctc gactcctgcg acccgcaccg cacccccacc      300

cgggcccgga ggatgatgaa gctcaagtcg aaccagaccc gcacctacga cggcgacggc      360

tacaagaagc gggccgcatg cctgtgtttc cgcagcgaga gcgaggagga ggtgctactc      420

gtgagcagta gtcgccatcc agacagatgg attgtccctg gaggaggcat ggagcccgag      480

gaggagccaa gtgtggcagc agttcgtgaa gtctgtgagg aggctggagt aaaagggaca      540

ttgggaagat tagttggaat ttttgagaac caggagagga agcacaggac gtatgtctat      600

gtgctcattg tcactgaagt gctggaagac tgggaagatt cagttaacat tggaaggaag      660

agggaatggt ttaaaataga agacgccata aaagtgctgc agtatcacaa acccgtgcag      720

gcatcatatt ttgaaacatt gaggcaaggc tactcagcca acaatggcac cccagtcgtg      780

gccaccacat actcggtttc tgctcagagc tcgatgtcag gcatcagatg actgaagact      840

tcctgtaaga gaaatggaaa ttggaaacta gactgaagtg caaatcttcc ctctcaccct      900

ggctctttcc acttctcaca ggcctcctct ttcaaataag gcatggtggg cagcaaagaa      960

agggtgtatt gataatgttg ctgtttggtg ttaagtgatg gggctttttc ttctgttttt     1020

attgagggtg ggggttgggt gtgtaatttg taagtacttt tgtgcatgat ctgtccctcc     1080

ctcttcccac ccctgcagtc ctctgaagag aggccaacag ccttcccctg ccttggattc     1140

tgaagtgttc ctgtttgtct tatcctggcc ctggccagac gttttctttg atttttaatt     1200

tttttttttt attaaaagat accagtatga gatgaaaact tccaataatt tgtcctataa     1260

tgtgctgtac agttcagtag agtggtcact ttcactgcag tatacattta tctacacatt     1320

atatatcgga catataatat gtaaataaat gacttctaga aaga                      1364


<210> 1447
<211> 5880
<212> DNA
<213> Homo sapiens

<400> 1447
gctgctgctg cagtgggaca ggtggcggcg accggcggcg tccgaggaga tttaatccag       60

agactgactt cactatagaa cccacagttg tatcaatggt tggggaaaga tagtggcaac      120

aggcaaagga gaaacagctc tgacatacaa agaaaatgag tatgctaaag ccaagtgggc      180

ttaaggcccc caccaagatc ctgaagcctg gaagcacagc tctgaagaca cctacggctg      240

ttgtagctcc agtagaaaaa accatatcca gtgaaaaagc atcaagcact ccatcatctg      300

agactcagga ggaatttgtg gatgactttc gagttgggga gcgagtttgg gtgaatggaa      360

ataagcctgg atttatccag tttcttggag aaacccagtt tgcaccaggc cagtgggctg      420

gaattgtttt agatgaaccc ataggcaaga acgatggttc ggtggcagga gttcggtatt      480

tccagtgtga acctttaaag ggcatattta cccgaccttc aaagttaaca aggaaggtgc      540

aagcagaaga tgaagctaat ggcctgcaga caacgcccgc ctcccgagct acttcaccgc      600

tgtgcacttc tacggccagc atggtgtctt cctccccctc caccccttca aacatccctc      660

agaaaccatc acagccagca gcaaaggaac cttcagctac gcctccgatc agcaacctta      720

caaaaactgc cagtgaatct atctccaacc tttcagaggc tggctcaatc aagaaaggag      780

aaagagagct caaaatcgga gacagagtat tggttggtgg cactaaggct ggtgtagtcc      840

ggtttcttgg ggagaccgac tttgccaagg gggagtggtg tggcgtggag ttagatgagc      900

cacttgggaa gaatgatggc gctgttgctg gaacaaggta ttttcagtgt caacccaaat      960

atggcttgtt cgctcctgtc cacaaagtta ccaagattgg cttcccttcc actacaccag     1020

ccaaagccaa ggccaacgca gtgaggcgag tgatggcgac cacgtccgcc agcctgaagc     1080

gcagcccttc tgcctcttcc ctcagctcca tgagctcagt ggcctcctct gtgagcagca     1140

ggcccagtcg gacaggacta ttgactgaaa cctcctcccg ttacgccagg aagatctccg     1200

gtaccactgc cctccaggag gccctgaagg agaagcagca gcacattgag cagctgctgg     1260

cggaacggga tctggagagg gcggaggtgg ccaaggccac gagccacgtg ggggagatag     1320

agcaggagct agctctggcc cgggacggac atgaccagca tgtcctggaa ttggaagcca     1380

aaatggacca gctgcgaaca atggtggaag ctgctgacag ggagaaggtg gagcttctca     1440

accagcttga agaggagaaa aggaaggttg aggaccttca gttccgggtt gaagaagaat     1500

caattaccaa aggtgatctt gagacgcaga ccaaactgga gcatgcccgc attaaggagc     1560

ttgaacagag cctgctcttt gaaaagacca aagctgacaa actccagagg gagttagaag     1620

acactagggt ggctacagtt tcagaaaagt cacgtataat ggaactggag aaagacctag     1680

cattgagagt acaggaagta gctgagctcc gaagaaggct agagtccaat aagcctgctg     1740

gggatgtgga catgtcactt tcccttttgc aagagataag ctctttgcaa gaaaagttag     1800

aagtcacccg tactgaccac cagagagaaa taacttctct gaaggagcat tttggagccc     1860

gggaagaaac tcatcagaag gagataaagg ctctgtatac cgccacggaa aagctttcca     1920

aagagaacga gtcattgaaa agcaagctgg agcatgccaa caaagagaac tcagatgtga     1980

tagctctatg gaagtccaaa ctggagactg ccatcgcatc ccaccagcag gcgatggaag     2040

aactgaaggt atctttcagc aaagggcttg gaacagagac ggcagaattt gctgaactaa     2100

aaacacaaat agagaaaatg agactagatt accaacacga aatagaaaat ttgcagaatc     2160

aacaagactc tgaacgggct gcccatgcta aagagatgga agccttgagg gctaaactga     2220

tgaaagttat taaagaaaag gaaaacagtc tggaagccat caggtcgaaa ctggacaaag     2280

cagaagacca gcatctcgta gaaatggaag acacgttaaa caaattacag gaagctgaaa     2340

taaaggtaaa ggagctagag gtactgcaag ccaaatgcaa tgaacaaacc aaggttattg     2400

ataattttac atcacagctc aaggctactg aagaaaagct cttggatctt gatgcacttc     2460

ggaaagccag ttccgaaggt aaatcggaaa tgaagaaact tagacagcag cttgaggcag     2520

ctgagaaaca gattaaacat ttagagattg aaaagaatgc tgaaagtagc aaggctagta     2580

gcattaccag agagctccag gggagagagc taaagcttac taaccttcag gaaaatttga     2640

gtgaagtcag tcaagtgaaa gagactttgg aaaaagaact tcagattttg aaagaaaagt     2700

ttgctgaagc ttcagaggag gcagtctctg ttcagagaag tatgcaagaa actgtaaata     2760

agttacacca aaaggaggaa cagtttaaca tgctgtcttc tgacttggag aagctgagag     2820

aaaacttagc agatatggag gcaaaattta gagagaaaga tgagagagaa gagcagctga     2880

taaaggcaaa ggaaaaactg gaaaatgaca ttgcagaaat aatgaagatg tcaggagata     2940

actcttctca gctgacaaaa atgaacgatg aattacgtct gaaagaaaga gatgtagaag     3000

aattacagct aaaacttaca aaggctaatg aaaatgcaag ttttctgcaa aaaagtattg     3060

aggacatgac tgtcaaagct gaacagagcc agcaagaagc agctaaaaag catgaggaag     3120

aaaagaaaga attggagagg aaattgtcgg acctggaaaa gaaaatggaa acaagccaca     3180

accagtgtca ggagctgaaa gccaggtatg agagagccac ttctgagaca aaaaccaagc     3240

atgaagaaat cctacagaac ctccagaaga cgctgctgga cacagaggac aagctgaagg     3300

gcgcacggga ggagaacagt ggcttgctgc aggagctgga ggagctgaga aagcaagccg     3360

acaaagccaa agctgctcaa acagcggaag atgccatgca gataatggaa cagatgacca     3420

aagagaagac tgagactctg gcctccttgg aggacaccaa gcaaacaaat gcaaaactac     3480

agaatgaatt ggacacactt aaagaaaaca acttgaaaaa tgtggaagag ctgaacaaat     3540

caaaagaact cctgactgta gagaatcaaa aaatggaaga atttaggaaa gaaatagaaa     3600

ccctaaagca ggcagcagct cagaagtccc agcagctttc agcgttgcaa gaagagaacg     3660

ttaaacttgc tgaggagctg gggagaagca gggacgaagt cacaagtcat caaaagctgg     3720

aagaagaaag atctgtgctc aataatcagt tgttagaaat gaaaaaaaga gaatccaagt     3780

tcataaaaga cgcagatgaa gagaaagctt ccttgcagaa atccatcagt ataactagtg     3840

ccttactcac agaaaaggat gccgagctgg agaaactgag aaatgaggtc acagtgctca     3900

ggggagaaaa cgcctctgcc aagtccttgc attcagttgt tcagactcta gagtctgata     3960

aggtgaagct cgagctcaag gtaaagaact tggagcttca actcaaagaa aacaagaggc     4020

agctcagcag ctcctcaggt aatacagaca ctcaggcaga cgaggatgaa agagcccagg     4080

agagtcagat tgatttccta aattcagtaa tagtggacct tcaaaggaag aatcaagacc     4140

tcaagatgaa ggtggagatg atgtcagaag cagccctgaa tgggaacggg gatgacctaa     4200

acaattatga cagtgatgat caggagaaac agtccaagaa gaaacctcgc ctcttctgtg     4260

acatttgtga ctgctttgat ctccacgaca cagaggattg tcctacccag gcacagatgt     4320

cagaggaccc tccccattcc acacaccatg gcagtcgggg tgaggaacgc ccatactgtg     4380

aaatctgtga gatgtttgga cactgggcca ccaactgcaa tgacgacgaa accttctgat     4440

gaagcctcca gtggagaact gggcttgctc agacgcactc gcattgacac aacgtaacac     4500

cagcattgtg tgtgcagact tcaggagaac tcatgttatt ttttaacccc gtcaacaaat     4560

ctaggaaaat attttgatct tcaacaaatt gccctttagt ctccccgtat gagttagaat     4620

aataaatatt tagtaggtga gttttcacct cgaattttgt tttcttgatt tttacgtttg     4680

aagacattgc accagatgcc attacattta ttggcccccc gaccttgtag aaaaacccct     4740

accctcacaa taccttattt aagtaacttt aaattatgcc gttacttttc atatttgcac     4800

taagatattt ccaggctgca tttgtatatt tagatttttt ggttaagctt tgacactgga     4860

atgagttgaa aaaatgtgcc attttgcatt ttcatctact catttaaagt attttattct     4920

tattcaaaga aatatctgag ctctttgcac tacctgttat cagtagtgcc tttacttcag     4980

gcttgataat acttaggtgt gattataaaa tcatgaagca ggtaaaggga ggggcaagcc     5040

cccaaactgc tgtggggaca ttttataatc tatatgctgc acccacttaa tctactgtgg     5100

tgttttgttt attagttttg cataatttca gcttctatat attgtatgta tatatttttt     5160

aaaaatctat attttgggaa aaaaacatac acaatgtgtc tttctttttg gacatttacc     5220

tttttgaaaa agaaaacact taaaatgatc attaggacat aacagactag gccagacata     5280

gcatcttgtg gctttgcaac cattttcatt tgtttgtttt ccttttattt cttcaccaga     5340

tttaaataac tggaggaatt ttctccaatt tttttttcct tctctggcag gtatccccag     5400

cagtcaatta acaataagcc agtataaaac acctaaataa ccaatctaca atctcccttc     5460

acaagttttt ttactgtttt tagatgaatg tacgatgaga aattcaacgt taataattct     5520

ggattttctt atcacaaaaa agaaaatgaa ggacctcaaa gcacctgaac agtttatcga     5580

ccagtttgaa tctatttatc ttcatttgaa tgtcttctag aatatgtaaa aagtcataaa     5640

atgtatcttc catgctacat gtacaataag aacttctata attgtatata tgcctttgat     5700

gtattttccc ctcaagatta tcaactgtgt gttcgacagt gaatattcaa tctggtacca     5760

gttgaaattt ttggttataa atgtaatacg aattgtttca caaacagaaa acatgtaaag     5820

cagtattaaa atttggccaa acaagtgttc tgtatctact ttaataaatg gttattcttt     5880


<210> 1448
<211> 1194
<212> DNA
<213> Homo sapiens

<400> 1448
atgggggact cttgccctgc agtcacattc aggtcccaga aagagaatcg agctggactt       60

caggagaagc tgcgctacct ccagcagcag ctgcaggatg agacgccgcg acggcaggag      120

gccgagctgc aggagccgga ggagaagcag gagccggagg agaagcagga gccggaggag      180

aagcagaagc cggaggctgg cctctcctgg aacagcctgg gccccgccgc cacgtcccag      240

ggctgccccg gcccgccagg gagtcccgac aaaccctcgc ggccacacgg cctggtcccc      300

gcaggctggg gaatggggcc tcgggctggc gagggcccct acgtgagcga gcaggaattg      360

cagaagctgt tcaccggcat cgaagagctg aggagagagg tgtcctcact gaccgcccgg      420

tggcatcagg aggagggggc ggtgcaggaa gccctgcggc tgctcggggg cctgggcggc      480

agggtcgacg gcttcctagg ccagtgggag cgggcacagc gcgaacaggc acagacggcg      540

cgggacttgc aggagctgcg aggtcgggcg gatgagctgt gcaccatggt ggagcggtca      600

gcagtgtctg tggcttcact gaggagcgaa ctggaggggc tgggcccact gaaacccatt      660

ctggaggagt tcgggcggca atttcagaac tctcgaagag ggcctgacct ctccatgaac      720

ctggatcggt cccaccaagg caactgtgcc cgctgtgcca gccaggggtc gcagttgtct      780

acggagtccc tgcagcagct gctggaccga gcactgacct cactagtgga cgaggtgaag      840

cagaggggcc tgactcctgc ctgtcccagc tgtcagaggc tacacaagaa gattctggag      900

ctggagcgcc aggccttagc caaacacgtc agggcagagg ccctgagctc cacccttcgg      960

ctggcccaag acgaggccct gcgggccaag aacctactgc tgacagacaa gatgaagcca     1020

gaggagaaga tggccactct ggaccatcta cacttgaaga tgtgctccct ccacgatcat     1080

ctcagcaacc tgccacttga ggggtccacg ggaacaatgg ggggaggcag cagtgcagga     1140

acccccccaa aacagggggg ctcagcccct gaacaataaa tggcctctca tgct           1194


<210> 1449
<211> 4050
<212> DNA
<213> Homo sapiens

<400> 1449
gtactcggcc gcctgagcgc cgacccacgc cctgcctgct cttccagtcc agccaacact       60

ctaagcaggc accgcctcca ctcgcagccc ccgggatggg tcccactccc taccgcagat      120

ccccaggccc cctccaccca gtcggctagc cctcgcctct gccatccgat actaaaatgt      180

ctgatgatgc tggtgacacc ttagccactg gagacaaagc agaagttact gagatgccta      240

atagtgattc tttacctgag gatgcagaag tgcattgtga ttcagctgca gtttcacatg      300

agccaacacc agctgacccc agaggggagg ggcatgaaaa tgcagctgtg cagggtgcag      360

gggctgccgc cattgggccc cctgtgcagc ctcaggatgc caacgccctg gagccccctc      420

tcaatggaga cgtgactgag gatacacttg ctgaatgtat tgattccgtc agccttgagg      480

cagaacccag atccgaaata cccctgcaag aacagaatta tctggctgtg gattcccctc      540

caagtggagg aggatgggca ggctggggat cctggggcaa atctctgctg tcgtcagcat      600

ctgccacagt aggtcatgga ttgacggcag tcaaggaaaa agcaggagcc actctacgga      660

ttcatggtgt aaattctgga tcttctgaag gagcccaacc aaatactgaa aacggagtcc      720

ctgaaataac agatgcagcc acagatcagg gccctgcaga aagcccaccc acttcccctt      780

catcagcctc tcggggtatg ctgtctgcca tcaccaatgt ggttcaaaac acaggtaaaa      840

gtgtcttaac tggaggcctt gatgcgttgg aattcatcgg caagaaaacc atgaatgtcc      900

ttgcagaaag tgacccgggc tttaagcgga ccaagacgct catggagaga actgtttcct      960

tgtctcagat gttaagggaa gctaaggaga aggagaagca gagactggca cagcagctca     1020

cgatggagag aaccgcgcac tacgggatgc tgtttgatga atatcaaggc ttgtcacacc     1080

tggaagccct ggaaattctg tccaatgaaa gcgaaagcaa ggttcagtca tttttagcat     1140

cacttgatgg agagaagctg gaactcttaa aaaatgacct aatttccatt aaagacatct     1200

ttgcagccaa agaattagag aatgaagaaa atcaagaaga acaaggctta gaagaaaagg     1260

gagaagaatt tgctcgcatg cttacagagc ttctctttga attacatgtg gcggccacac     1320

ctgacaaact caataaggcc atgaagaggg ctcatgactg ggtggaagag gatcaaaccg     1380

tggtgtcagt agatgtggca aaagtgtccg aagaagaaac aaagaaggaa gaaaaggaag     1440

agaaatctca agaccctcaa gaagacaaaa aggaggaaaa gaaaactaag accatagagg     1500

aagtatacat gtcgtccatt gaaagtctgg cggaggtaac agcgcgctgt attgagcagc     1560

ttcataaagt agcagaatta attcttcatg gacaagaaga ggaaaaacca gctcaggacc     1620

aagcaaaagt tctaataaaa ttaactactg caatgtgcaa tgaagtggcc tctttatcaa     1680

agaagtttac gaattcttta accactgttg ggagcaacaa gaaggccgag gtccttaacc     1740

ccatgatcag tagtgtattg ttagagggct gcaacagtac aacgtacata caggatgcct     1800

tccagctgct gctgcctgtt ctgcaggtct cacatatcca gaccagttgt ttgaaagcac     1860

agccgtgacc tggccagact ccatctagtt aaaggagaca gctggccgcc ttgcctcaat     1920

atgtaccatt taaggggatg ttctctgtgc gcctggccac agacatccat ttgaggacac     1980

tacaagcaat tttgcacaga caatattgag aatgcaaatt tagagagagt tatcatttct     2040

ctcaatgtgt ataattgttt ttacaaacaa ttgtgttttc tttatgttaa tttaaactta     2100

cacagcttat attgaaaatt tcctttcatc tgaaatttat ttacaaatat tcgtgttcat     2160

tttcctggtt aagcatgcta tatttagaaa ctcatgggga gaccttagac ttttgtttaa     2220

tcctttatgt ttcaaccttt aaatgttcca ttcttatagt attactttaa atcaattcta     2280

aaactgaact ttgttttgtt acataaatgt cgcaggcaaa aataacacta cttatagatt     2340

ttacctatta tggtaaaaaa taggaacata ttgtcattct tttttttttt ttttttttga     2400

gacagagtct cactctgtcg ccaggctgga gtgcgttggc acaatctcgg ctcactgcaa     2460

cctccgcctc ctgggttcaa tcgattctcc tgcctcagcc tcctgagtag ctgggactac     2520

aggtgtgtgc caccacgccc agccaatttt ttttgtattt ttagtagaga cagggtttca     2580

ccatgttggc caggatggtc tcgatctcct gacctcgtga tctgcccgcc tcagcctccc     2640

aaagtgctgg gattacaggc ttgagccacc gcgcccggcc ggtcattcat tcttgcaaca     2700

agcatttatt gagcacctac tgtgtgctca cagtaaagaa acgtgatctt atcccagtag     2760

aggtagatat tctgaaaaag aataattctt aaactgctta aaacaggggt ccccaccccc     2820

aggccacaga ccagtaccag tccgtggcac tggttaggaa ccaggccaca cagcaggggg     2880

tgagcggtgg gtgagtgagc acagcttcat ctgtatttac agctgctccc cagagcttgc     2940

attactgcct gagctctgcc tcccgtcagg tcagcagcag cattagagtc tcatgggagt     3000

gcgaaccctg ttgtgaactg cacatgcgag ggatctaggt tgtgcactcc ttatgagaat     3060

ctaatgcctg atgaatctaa tgcctcatga tctgaggttg aatagcttcg tgccgaaacc     3120

atcccccacc cccatcccgc taccccgagt ccgtgaaaaa attgtcttcc atgaaaccgg     3180

tccctggtac cagaaaggtt ggggaccact ggcttaaaat accaataaat ttttgaacct     3240

taaaaacttt gaagaacaag gtaaattggt gttttattta atgtcctacc ctttaatttg     3300

ttgcattttc ctatactctt tacactattt tatcccaaac tatgtatatg aggtgaaaat     3360

atatatgaaa agggatactg aagaatattt agtttaaaat taatttctta cgatcacgag     3420

cacatggtgg cataattaca aagcttggaa gtattcaaat agaaaatcaa aggtgtttca     3480

atacagtaga atcccaggac tgcattttaa aatcgcctca cagatcacac tcgctggtgg     3540

caaatatcat catcgttgct aaaggacaga aaatactgat gtgtgtttta actaactggt     3600

atattgatcc atgggaggct gcacagaaga ccctgcggcc aggaggggca ttgtcagtgg     3660

ctgcttctcc tgagctccac gccttcattg cagctgcatg ttcgatacaa tacacctgct     3720

tcacagcccc atggacatcc ctacaggtac tgtcatgtga agccttgcct agtagttctc     3780

tccagggcaa atgaagctca cagttttgca aggtggaaac ctcttattca catttgcttt     3840

gattccccga tggagtagac tgcctttgtt ccatacaggc aaagtaagga tattttaata     3900

tcatcctact tcttattagc atttcatttg tctatgtact gtatttcatt tgtatgtctc     3960

ctgaaacatc caaatagaga acataagaac actttatgta caatctggaa aaaaattacc     4020

tgagaaatca attaaagatt tttccccttt                                      4050


<210> 1450
<211> 3750
<212> DNA
<213> Homo sapiens

<400> 1450
ggctagaccc ctcccctcct tgcgagtgta tgtcagtgac ccagaggcgg tgtgaggcgg       60

agggaccgtc ggggggcgcc gccgccgcct ccactagcag cagcggcagc agccctagtc      120

ccgcggtgcg gtcgaattgg tccccagccc tccgggagcg caccacaaag cagccccaac      180

gcctctccct gcgtccgcgg ctcctcagcg ctcggctccg tggtcaactt cccctcgctg      240

ggctcggctg gcgggcgcgg agggcagcgg cggaacggcg ggctgtctgc tcgcgctccc      300

cgcgcacaac acttcaccct ctcgcctcgg gtctcggggg ccgctctggg atcccggcca      360

ccagcaattg tccggaaata atgcaaaagg tgtcccaagg ctcctgacca gtgaacaaag      420

atttgagaaa gacagccaag ctcatgtttt ctcctgatca agaaaatcat ccatctaaag      480

caccagtaaa atatggtgaa ctcattgtct tagggtataa tgggtctctc ccaaatggcg      540

atagaggaag gaggaaaagt aggtttgctt tgtttaaaag acctaaggca aatggggtga      600

agcccagcac tgtgcatatt gcttgtactc ctcaggctgc aaaggcaata agcaacaaag      660

accagcatag catatcatat actttatctc gggcccagac tgtggtggtt gaatatactc      720

atgacagcaa caccgatatg tttcagattg gccggtcgac tgaaagcccc attgattttg      780

tagtaactga cacggttcct ggaagtcaaa gtaattctga tacacagtca gtacaaagca      840

ctatatcaag atttgcctgc agaatcatat gtgaacggaa tcctcccttt acagcacgga      900

tttatgctgc aggatttgac tcatcaaaaa acatctttct tggggagaag gctgccaaat      960

ggaagacatc agatggacag atggatggct tgaccactaa tggtgttctt gtgatgcatc     1020

cacgcaatgg gttcacagaa gactccaagc ctggaatatg gagagaaata tcggtgtgtg     1080

gaaatgtatt tagcctacgt gaaaccagat cggctcagca gagaggaaaa atggtggaaa     1140

ttgaaaccaa tcagttacaa gatggctcgt taattgacct ctgtggtgca acattgttat     1200

ggcgtactgc agaaggcctt tcccacactc ctaccgtgaa gcatttagaa gctttaagac     1260

aggaaatcaa tgcagcacga cctcagtgcc ctgtagggtt caacacacta gcatttccta     1320

gtatgaagag gaaagacgtt gtagatgaaa aacaaccatg ggtatatcta aactgcggcc     1380

atgtacatgg ctatcataac tggggaaaca aagaagaacg tgatggaaaa gatcgtgaat     1440

gtcctatgtg taggtctgtt ggtccctatg ttcctctgtg gcttggatgt gaagctggat     1500

tttatgtgga cgccggccct ccaacccatg cgtttagccc gtgtgggcat gtgtgttcag     1560

aaaagacaac tgcctattgg tcccagatcc cacttcctca tggtactcat acttttcatg     1620

cagcctgtcc cttttgtgca catcagttgg ctggtgaaca aggctacatc agacttattt     1680

ttcaaggacc tctagactaa cagaccattg tcttgcagga ctacattata aatttataag     1740

ctaagtgagt tgggttttcg aacctgttgt ccacgtcaca gtttttctgc tctggtcatt     1800

tgcattaaga tgaagaattt tttaaaacat ttataataaa tagtagcaat ttctgagcaa     1860

aaatctggga aactcaagca aaggaatttc tgaaagtatc agtcttctga attctgagtt     1920

ttgaaaatat attttgagga gaaaaagaca tagtctaatt tgatgccttc cttttagtgt     1980

ttttgaatca cctatcctca gtgctgaaat tgttttgtat aactgagggt actgttggtt     2040

caaactatgt tagtttacag tttgttgcaa acattgtaaa atacagcgac atgtatatta     2100

acttttttct atttatcttt attatagaaa ataccttaga atgttcttga tagagtagca     2160

tggtaacgat ggtgtcacac ccttggtgtg aatggtagct tagtgagcaa cctagctcaa     2220

ggatttgcaa agttaggaag aaggacgaga gagcctctct ccccacccca atctaaatat     2280

ggaatttggt aaattagaat actttgtaat ttgtaagacc aaattcatac taattacccg     2340

cgtgaaaggt gtttgttttt aacaacattg aagataatca ggaaagattt tttcttaatg     2400

tttctctcga gcgtagtact ataacaaaaa cttaatgcta agaaacattt tatatgctcc     2460

tttggatatg caatttaatc tagattatct atttttctcc catgataact aatctgtttt     2520

tagtatcagc agcatttggc aagtttattt tttggatata aactgtggtt catctgttca     2580

ctgtttctag aaaaaaatca ttgccataag aaaaagtata aattagcaag aaaggagagt     2640

gacttgattt gcttttggaa aaagaaatgc ttaattaatt attctgtatt tggccttatt     2700

cgggcattag gaaatctaga gatctaaagg gttgaatgac aatagtgccc ccgtttttag     2760

cagaccagcc ttaactctgg gtttgaatcc taaggagatt gccacagtga gacttaagga     2820

aatgtttggt tggcagatga gcaccaatga ctgcagcgtg gagtgacgca ctgcatggtc     2880

tgtttattct ctaattccaa tatgtctttt gcttccagaa gcaagaaaag tttcttctct     2940

cccctccttc ccaccctttt ttcaaaggca ccacaagtat agacagttgc actacatcaa     3000

atcttttttt gacacttgta gaaaccagta cacttttaga ttagacagta tcttctttta     3060

atattttgat ttgttttcct ttagtttgaa aagttgtata atacttaact gactgtagca     3120

aagttttata tgtggtagca tacctttaat ttatcctatt acaaaactgt tctgaatttt     3180

cttttggttt ttaaaaaaca aaacttgttg cttagaagcc atgaattatt ttattttact     3240

tcaactgtcg aaacttcctt gttttaaaaa atgatcattt gggttcactc aggaaatgca     3300

tgtcaggaaa cttgtattat aagtttatta gttgtgatgt atcagtaact gctgttaccc     3360

ctttttcaaa gaaatgtaat tgattttgaa gttttctaga ttgtcacatg ctttgtgact     3420

aatgcaagaa agcaagtcct gtgttgtatt tgttctagtc atttttattc aggctatata     3480

ttgtagctta atttttattt gcaattaatt tatttaaact aagtaaatac ttttcaaaat     3540

acataattga attcgtctct gtgagttcat ttttgcataa tcgagaatga gaaaccagaa     3600

gtgaaaactg tgaacaactc tattccacac tccaaaaata ctcatttgaa atagatgaag     3660

agtttgcatt taatgtaaca ctttaaagta tctggttctt ttttaaaagc atctcttact     3720

aataaaggaa ctttgttagt ggttgaataa                                      3750


<210> 1451
<211> 6013
<212> DNA
<213> Homo sapiens

<400> 1451
aaaaataatg ccattttttt gaatgatgaa ctatggtata atgcatttag tgttcattcc       60

aaacgtcaat caataaataa catgggcctc tagctataag ggaaattcta taggtaaaag      120

aactgattga cccccacccc cataggtgct gtcctgctat ggaatccctt tgctcagttt      180

tctcctgtcc aatcaggtgg aatgtttcac aggcacatgg tttatacagc tcaaaataac      240

ttgggacctg tgagctgaca aatgctctgg ctccggtggt gacaggttgt ccagcttctt      300

acagccatct tcactgaaac taaggttaac tcctcactct ctatggacgg ctactctcta      360

tttccaaggg cgtgaagaat ttccctcttc tcctgtgctt tcatctaaaa gttctccctg      420

gataattatc attgcagtgg agtgcctgga ttggacatcc tcatctgggt caactaaaaa      480

aagaaagcat gcaagacgac agcatagaag cttctacttc catatctcag cttctaagag      540

agagctattt agctgaaacc agacatcggg gaaacaatga gaggagtcga gcggagccct      600

cctccaaccc ttgccatttc ggcagtcctt ctggggccgc tgaaggaggc ggaggccaag      660

atgaccttcc agatctttca gcctttctga gccaagaaga attagacgaa agtgtcaatt      720

tggcaagact ggccatcaat tacgaccctt tggagaaggc agatgaaact caagctagaa      780

aacgactttc tcctgatcag atgaaacact cacctaattt aagttttgag cctaacttct      840

gccaggataa ccctcgaagt cccaccagct ctaaagaaag cccccaggag gcaaaaaggc      900

cacagtattg ttctgaaacc cagtccaaaa aagtattttt aaataaggct gccgacttca      960

ttgaagagct atcctccctt ttcaaatccc acagctccaa aaggattaga cctcgtgcct     1020

gcaaaaacca caagagtaaa ctggaatctc aaaacaaagt tatgcaggaa aacagctcca     1080

gtttctcaga tctgtcagaa agacgagaaa gatcttctgt tcccatccct atccctgcgg     1140

ataccaggga taatgaagtg aatcacgccc tggaacagca ggaagccaag aggcgtgaag     1200

cggagcaggc tgccagtgag gcggctggtg gagacactac accagggtct tccccttcat     1260

ctctgtacta tgaagaacct ctggggcaac ctccccggtt cactcaaaag ttacggagca     1320

gagaagttcc agaaggaact cgagtacagt tggattgcat agtggtagga attccaccac     1380

ctcaagtaag gtggtactgt gaaggcaagg agcttgaaaa ttccccagat attcacatcg     1440

tccaggcagg aaatctgcac tcactgacca ttgcggaagc ctttgaagag gacacaggac     1500

gctattcctg ctttgcttct aacatctatg ggacagattc gacttctgct gagatttata     1560

tagaaggggt ttcttcttct gactcagaag gcgaccctaa caaggaagag atgaatcgaa     1620

tccagaagcc aaatgaggtg tcatctcctc ccactacctc tgcagtcatt cctccagcag     1680

taccccaagc ccagcatttg gtggcccaac ctcgtgtggc aaccatccag cagtgtcaga     1740

gccccaccaa ttacttgcag ggattggatg gaaaacctat cattgcagct cctgtgttta     1800

caaagatgct acaaaatttg tcagcttctg agggtcagct ggttgtcttt gaatgcagag     1860

taaaaggagc tccatctcct aaggttgagt ggtatagaga agggacttta atagaagatt     1920

ctccagattt taggatttta cagaaaaaac ctcgatccat ggcagagcca gaggagattt     1980

gcaccttggt cattgctgag gtgtttgcag aagattctgg gtgcttcaca tgtactgcaa     2040

gcaacaaata cggcacagtg tcaagcattg cacagctgca cgtgagagga aatgaggacc     2100

tcagcaacaa cgggtctctt cactcagcca actctaccac caacctggca gctattgagc     2160

cacagccctc cccaccccac tcagagcctc catctgtgga acaacccccc aaacccaaac     2220

tcgagggggt tctggtgaac cacaatgagc cccggtccag ctccaggatt gggcttcgtg     2280

tgcacttcaa cctgcctgaa gatgacaaag gaagtgaagc atcctccgag gctggtgtgg     2340

tgaccaccag acagaccagg cccgattctt tccaggagag gttcaacgga caggcaacaa     2400

aaaccccaga gccttcttcc cccgtgaaag agccccctcc agttctggcc aaacccaaac     2460

ttgattccac tcagttacaa cagcttcata accaagtctt actggaacaa caccaattgc     2520

aaaacccacc tccttcatct cctaaggagt ttcctttcag catgactgtt ttgaactcca     2580

atgctccccc agcggtgaca acatccagta agcaggtgaa ggctccttca tcacagacgt     2640

tcagcttggc ccggccgaag tatttcttcc cctccacgaa caccaccgca gcaactgtgg     2700

ccccttccag ctctccggtg ttcactttga gcagcactcc tcaaactatt cagaggacag     2760

tgagcaaaga aagcctctta gtgtctcacc cctctgtgca aaccaaatct ccaggagggc     2820

tttccatcca aaatgagcca ctcccaccag gcccaacaga accaacacca ccaccattca     2880

cattttccat ccccagcgga aaccagtttc agccccgctg tgtgtcccca attcctgtct     2940

ctcctaccag ccggattcag aacccagtgg ctttcctcag ctctgttctg ccttctctcc     3000

ctgccatccc acccacaaat gccatggggc tgcctagaag tgcaccatcc atgccatccc     3060

agggattagc gaagaaaaat acaaagtctc ctcaaccagt gaatgatgat aacattcgtg     3120

aaactaagaa cgcagtgatt cgagacttgg ggaaaaaaat aactttcagt gatgtcagac     3180

caaaccagca ggagtacaaa atttcaagct ttgagcagag gctgatgaat gaaatagagt     3240

ttcgcttgga acgtactcct gttgatgaat cagatgatga aattcaacat gatgagatcc     3300

ccacgggcaa gtgtattgct cccatctttg acaagagact caagcacttc cgggtcacag     3360

aaggctctcc agttacattc acctgcaaaa ttgttgggat acctgttcca aaggtttact     3420

ggttcaaaga tgggaagcag atttctaaga gaaatgagca ctgcaaaatg aggcgagaag     3480

gagatgggac atgctctctg cacattgaat ccactaccag tgatgacgat ggcaactaca     3540

ccatcatggc agccaacccc caggggagaa tcagctgttc tggccacttg atggtacaaa     3600

gtttgcccat tcgcagtcgg ctaacctctg ctggtcagtc tcacagggga agatcccgag     3660

tgcaagaaag agacaaagag cccctacagg aacgcttttt ccgaccacat ttcctgcagg     3720

ctcctgggga tatggtagct catgaggggc gcctctgtcg gctggactgt aaggtgagtg     3780

gtttaccgcc cccggagctg acatggctac tcaatggcca acctgtgcta ccagatgcct     3840

cccacaagat gctggtcagg gagaccggag tccactctct gctcattgac ccactcactc     3900

agcgcgacgc agggacctat aagtgcatcg ctaccaacaa aaccgggcag aattctttta     3960

gtctggagct ctctgtagta gccaaagagg tgaagaaagc acctgtgatc ctggagaaac     4020

tacagaactg cggtgttccc gaaggccacc ccgtgagact ggagtgccgc gtgataggca     4080

tgcccccacc tgtgttctac tggaagaaag acaatgagac catcccttgc accagagaga     4140

ggatcagtat gcaccaggac acaacagggt atgcctgcct tctcattcag ccagccaaga     4200

aatcagacgc tggatggtac acgttgtcag ccaagaatga agccggcatc gtgtcgtgca     4260

ctgccaggct ggatatatac gctcagtggc accatcagat cccaccgccc atgtctgtcc     4320

ggcccagtgg cagtcgctac ggatctctca ccagtaaagg acttgacata ttttctgcct     4380

tttcctccat ggaaagcacg atggtgtatt catgctcttc tcggagtgta gtggagagtg     4440

atgaacttta agaatgtcta ggtacctgct gtgtaagaga gcggactgtg gagggggaat     4500

gagaacaagc cagacttggt ggtttccaag caaccgaagt tgagtaagtt cccacactgc     4560

tggacctgtg gcaaagagtg ctttgaataa gtcagctagg gattcttgca gtctcagctg     4620

agggagaaag gtagggctgt gccttctaaa gattccaaca gagatgtgag aagataatac     4680

agatgaacca aagatgtcac acagttgcca tccactgctt tgggaaaaaa ctagcatgct     4740

cccctgctcc ctgttgtgtt agggatgttt aggtcatact aggagcaatt aggagccata     4800

tgcctgggct gagaagagct aggcagtagt gaccttagga tatgactaac tcaccaaaca     4860

atgccaagga gaaaggcgga caggtcacca tcacctttca tcgattacat gtatagcagt     4920

agttttggtg aattcaccaa atcagcttcc acttagcatt aggaggtcat gccatacaac     4980

tcacgtatgc gggcaaacac ttttgatttg catatcctgg gtgtactgag ccacataata     5040

aggtgtcaaa atgtgcttga gattccaaaa acttgctgaa acacttgata ttgcacagtg     5100

cacttatttt gtggccaaag catggcctta ccagcttgtc tgcactattt tcttttgggt     5160

ggtgactgtt tttttctgac tttgcatatc cctagacact agaactaaag gattggtaat     5220

aaaccaatca gaaagaaatc ctctgtgggg tcactttaaa aactactagc ttcaactacc     5280

acttacaaaa tgtgcaagag tcatcatttg cccataaaat acacctcatg ggctcctacc     5340

cctttcccca aaagtctgaa agtgtaggag gaaggaagag atacaaacaa ggagaggaaa     5400

tgatgggaga gtgttgtttt tgtcacttgc cccagcagag caggggtttt ggaaggagag     5460

gtctttaata gctttgaaat gctttgagat cattggtcaa attgcatttt ctatgtagag     5520

aatattctgc taggtggaaa agttgggaga aaggggaata tgcatcttta ttctaatcac     5580

caattcaaac cctgcctctt aaggaatttt tagacttaag ttcactgtga tatccctagt     5640

acctagaaga gtacctagca caaagtagac attcaataaa tatttgctgg ttgaatgaat     5700

cttctgttat tatgtctatt ataagataac ctaatcttat attctgcagg aatatgccac     5760

ccacacacca gtccaaacac tgccctggga atgctcatca cagcacagtt tgctctaggc     5820

tgtgcaggga aatgaattgc aggtgtctgt tttcaattcc ctgtgctgga atccctggtg     5880

ctgtctgtgc caagcacact cagctggcat tgtatttgtg tgaacagaca gtaactgctt     5940

agaaaggctt gaaactgtct tcacttcaag gcaaggattt ccagcataaa aataaattca     6000

ttcactggag aaa                                                        6013


<210> 1452
<211> 4751
<212> DNA
<213> Homo sapiens

<400> 1452
ggaagtggag gcggttggtg gggttggcgg ggctcagcga cgctgcgcgg gtggcggttt       60

gcgaactgcg ggtggactgt gtagtgaccg gcgtcccgct gtctcgcccc gtggcgggtg      120

agcgagggtg cgtggtgcgc ggcggcggcg gaacgaacgc ggtgcgggcg gggcgcccgc      180

cgcagggccc atggcctcct gcgcgagcat cgacatcgag gacgccacgc agcacctgcg      240

ggacatcctc aagctggacc ggcccgcggg cggccccagt gcagagagcc cacggccatc      300

cagtgcctac aatggggacc tcaatggact tctggtccca gacccgctct gctcaggtga      360

tagtacctca gcaaacaaga ctggtcttcg gaccatgcca cccattaacc tgcaagagaa      420

gcaggtcatc tgtctctcag gagatgatag ctccacctgc attgggattt tggccaagga      480

ggtggagatt gtggctagca gtgactctag catttcaagc aaggcccggg gaagcaacaa      540

ggtgaaaatt cagcctgtcg ccaagtatga ctgggaacag aagtactact atggcaacct      600

gattgctgtg tctaactcct tcttggccta tgccattcgg gctgccaaca atggctctgc      660

catggtgcgg gtgatcagcg tcagcacttc ggagcggacc ttgctcaagg gcttcacagg      720

cagtgtggct gatctggctt tcgcgcacct caactctcca cagctggcct gcctggatga      780

ggcaggcaac ctgttcgtgt ggcgcttggc tctggttaat ggcaaaattc aagaagagat      840

cttggtccat attcggcagc cagagggcac gccactgaac cactttcgca ggatcatctg      900

gtgccccttc atccctgagg agagcgaaga ctgctgtgag gagagcagcc caacagtggc      960

cctgctgcat gaagaccggg ctgaggtgtg ggacctggac atgctccgct ccagccacag     1020

tacctggcct gtggatgtta gccagatcaa gcagggcttc attgtggtaa aaggtcatag     1080

cacgtgcctc agtgaaggag ccctctctcc tgatgggact gtgctggcta ctgcgagcca     1140

cgatggctat gtcaagttct ggcagatcta cattgagggg caagatgagc caaggtgtct     1200

gcacgagtgg aaacctcatg atgggcggcc cctctcctgc ctcctgttct gtgacaacca     1260

taagaaacaa gaccctgatg tccctttctg gaggttcctt attactggtg ctgaccagaa     1320

ccgagagtta aagatgtggt gtacagtatc ctggacctgc ctgcagacta ttcgcttctc     1380

cccagatatc ttcagctcag tgagtgtgcc ccctagcctc aaggtttgct tggacctctc     1440

agcagaatac ctgattctca gcgatgtgca acggaaggtc ctctatgtga tggagctgct     1500

gcaaaaccag gaggagggcc acgcctgctt cagctccatc tcggagttcc tgctcaccca     1560

ccctgtgctg agctttggta tccaggttgt gagtcgctgc cggctacggc acactgaggt     1620

gctgcctgcc gaagaggaaa atgacagcct gggtgctgat ggtacccatg gagccggtgc     1680

catggagtct gcggccggtg tgctcatcaa gctcttttgt gtgcatacta aggcactgca     1740

agatgtgcag atccgcttcc agccacagct gaaccctgat gtggtggccc cactgcccac     1800

ccacactgcc cacgaggact tcacatttgg agagtctcgg cccgaactgg gctctgaggg     1860

cctggggtca gccgctcacg gctcccagcc tgacctccga cgaatcgtgg agctgcctgc     1920

acctgccgac ttcctcagtc tgagcagtga gaccaagccc aagttgatga cacctgacgc     1980

cttcatgaca cctagcgcct ccttgcagca gatcactgcc tctcccagca gcagcagcag     2040

cggtagcagc agcagcagca gcagtagcag cagctccctt acagctgtgt ctgccatgag     2100

cagcacctca gctgtggacc cctccttgac caggccacct gaggagctga ccttgagccc     2160

caagctgcag ctggatggca gcctgacaat gagcagcagt ggcagccttc aggcaagccc     2220

gcgtggcctc ctgcctggcc tgctcccagc cccagctgac aaactgactc ccaaggggcc     2280

gggccaggtg cctactgcca cctctgcact gtccctggag ctgcaggaag tggagcccct     2340

ggggctaccc caagcctccc ctagccgcac tcgttcccct gatgtcatct cctcagcttc     2400

cactgccctg tcccaggaca tccctgagat tgcatctgag gccctgtccc gtggttttgg     2460

ctcctctgca ccagagggcc ttgagccaga cagtatggct tcagccgcct cggcactgca     2520

cctgctgtcc ccacggcccc ggccagggcc cgagctcggc ccccagctcg ggcttgatgg     2580

aggccctggg gatggagatc ggcataatac cccctccctc ctggaggcag ccttgaccca     2640

ggaggcctcg actcctgaca gtcaggtttg gcccacagca cctgacatta ctcgtgagac     2700

ctgcagcacc ctggcagaaa gccccaggaa tggccttcag gaaaagcaca agagcctggc     2760

cttccaccga ccaccatatc acctgctgca gcaacgtgac agccaggatg ccagtgctga     2820

gcaaagtgac catgatgatg aggtggccag ccttgcctct gcttcaggag gctttggcac     2880

caaagttcct gctccacggc tgcctgccaa ggactggaag accaagggat cccctcgaac     2940

ctcacccaag ctcaagagga aaagcaagaa ggatgatggg gatgcagcca tgggatcccg     3000

gctcacagag caccaggtgg cagagccccc tgaggactgg ccagcactaa tttggcaaca     3060

gcagagagag ctggcagagc tgcggcacag ccaggaagag ctgctgcagc gtctgtgtac     3120

ccaactcgaa ggcctgcaga gcacagtcac aggccacgta gaacgtgccc ttgagactcg     3180

gcacgagcag gaacagcggc ggctggagcg agcactggct gaggggcagc agcggggagg     3240

gcagctgcag gagcagctga cacaacagtt gtcccaagca ctgtcgtcag ctgtagctgg     3300

gcggctagag cgcagcatac gggatgagat caagaagaca gtccctccat gtgtctcaag     3360

gagtctggag cctatggcag gccaactgag caactcagtg gctaccaagc tcacagctgt     3420

ggagggcagc atgaaagaga acatctccaa gctgctcaag tccaagaact tgactgatgc     3480

catcgcccga gcagctgcag acacattaca agggccgatg caggctgcct accgggaagc     3540

cttccagagt gtggtgctgc cggcctttga gaagagctgc caggccatgt tccagcaaat     3600

caatgatagc ttccggctgg ggacacagga atacttgcag cagctagaaa gccacatgaa     3660

gagccggaag gcacgggaac aggaggccag ggagcctgtg ctagcccagc tgcggggcct     3720

ggtcagcaca ctgcagagtg ccactgagca gatggcagcc accgtggccg gcagtgttcg     3780

tgctgaggtg cagcaccagc tgcatgtggc tgtgggcagc ctgcaggagt ccattttagc     3840

acaggtacag cgcatcgtta agggtgaggt gagtgtggcg ctcaaggagc agcaggccgc     3900

cgtcacctcc agcatcatgc aggccatgcg ctcagctgct ggcacacctg tcccctctgc     3960

ccaccttgac tgccaggccc agcaagccca tatcctgcag ctgctgcagc agggccacct     4020

caatcaggcc ttccagcagg cgctgacagc tgctgacctg aacctggtgc tgtatgtgtg     4080

tgaaactgtg gacccagccc aggtttttgg gcagccaccc tgcccgctct cccagcctgt     4140

gctcctttcc ctcatccagc agctggcatc tgaccttggc actcgaactg acctcaagct     4200

cagctacctg gaagaggccg tgatgcacct ggaccacagt gaccccatca ctcgggacca     4260

catgggctcc gttatggccc aggtgcgcca aaagcttttt cagttcctgc aggctgagcc     4320

acacaactca cttggcaaag cagctcggcg tctcagcctc atgctgcatg gcctcgtgac     4380

ccccagcctc ccttagctgc taagcctgcc ttgcccaggg gtgggatggc actgaaggcc     4440

agcagacagg cctaggctgg ggcagggtca cggctggcct ttacctgctc aggcccccat     4500

ctctggggtg tttgggggtc agggagcagg gagcactggc cgtggtctac agcgtgtggt     4560

agtcagaagg tttagctggg cccagggcag gtattgcgcc tgcttgggtt ctgccatgcc     4620

tggagcatga ccctgagatc gtgacaccac ttgagtggaa ttttccatgt tcctttttac     4680

ctctaatttg gatctttttg tttttgaaaa acattgagaa attcaattaa atgcttttgg     4740

aataaaatgg a                                                          4751


<210> 1453
<211> 613
<212> DNA
<213> Homo sapiens

<400> 1453
atggcggccc caacggccgt ccaggacgtg gagcgaaatg agctcgggcg ctgacggcgg       60

cggtggcgct gcggtggcgg cgcggtcgga caagggcagt cccggggagg acggtttcgt      120

cccgtcggcg ctggggaccc gcgagcattg ggatgctgtc tatgagagag aactgcaaac      180

tttccgagaa tatggagata caggtgaaat ctggtttgga gaagagagta tgaatcgact      240

aataaggtgg atgcagaaac acaagattcc actggatgct tcagtgcttg atattggaac      300

tggaaatggt gttttcctgg ttgaacttgc aaaatttggt ttctctaata ttactggaat      360

tgattactct ccttctgcaa ttcagctttc tggaagtatt atagaaaaag aaggtttatc      420

taacattaag ttaaaggtag aagacttttt gaatctctcc acacagctgt ctggatttca      480

tatttgtatt gacaaaggga cttttgatgc cataagcctt aatcctgaca atgcaattga      540

gaagaggaag caatatgtga aatctctctc cagggtgttg aaagtaaaag gcttttttaa      600

taacgtcatg taa                                                         613


<210> 1454
<211> 7673
<212> DNA
<213> Homo sapiens

<400> 1454
gcgggtcgtt agctgtcaga gccaagcggc gggctggcgg cgggctccga cgtctgcgcc       60

aggacctggc tggctgagcc cggcgcagca gcagcagcca gggcagcgcg gcccctactc      120

cctgtcaggt cgtagaggcg agcagggacc agctggtcgc cggcccctcg ggcaagatgg      180

ggaaccggga gatggaggag ctgatcccgc tggtgaaccg tctgcaggac gcgttttcgg      240

cgctgggaca gagctgcctg ctggagctgc cgcagatcgc cgtggtgggc ggccagagcg      300

ccggcaagag ctcggtgctc gagaacttcg tgggcaggga ctttctccct cgagggtcgg      360

gcattgtaac aagacgacct cttgtgctgc agcttgttac ttctaaagca gaatatgccg      420

agtttctaca ttgcaaagga aagaaattta cagattttga tgaagttcgc cttgagattg      480

aagcagaaac agatcgcgtg actggaatga ataaaggcat ttcctccata cccattaatt      540

tacgagtcta ttccccacac gtgttaaatc taacccttat tgatctacct ggaataacta      600

aagtgcctgt gggagatcag ccaccagata tcgagtatca gatcagagaa atgattatgc      660

agttcatcac gagggagaac tgtctgattt tagctgttac tccagccaac actgatcttg      720

caaactcaga tgcgctgaag ctagctaaag aagttgatcc tcaaggtctg agaaccattg      780

gagttatcac caaactggac cttatggatg aaggaacgga tgccagggat gttctagaga      840

acaaactgtt gcctcttcgc aggggttacg tgggggtggt aaacagaagc cagaaggaca      900

tagatgggaa gaaggacata aaggcagcca tgctggcaga gaggaagttt ttcctttccc      960

acccggctta cagacatatc gctgaccgaa tgggaacccc acacctgcag aaggtcctta     1020

atcagcaact taccaaccac attcgggata ccctaccaaa cttcaggaac aaactacagg     1080

gacagttgct ctccatagaa catgaagtag aagcctacaa aaatttcaaa ccagaagacc     1140

caacaaggaa gaccaaagca ttgctgcaga tggttcagca atttgctgtg gactttgaga     1200

agagaattga agggtcaggg gatcaagtag ataccctgga actctcaggt ggtgctaaaa     1260

tcaatcgtat ttttcatgaa cgctttcctt ttgagatagt aaagatggag ttcaatgaga     1320

aagaattgcg aagagaaata agctatgcaa tcaaaaacat acatggtatc aggacagggt     1380

tgtttactcc agacatggca tttgaagcga tagtcaagaa acagattgta aagttgaaag     1440

ggccttcctt gaagagtgtg gatctggtaa tacaagaatt aatcaacact gtgaagaagt     1500

gtaccaaaaa actggcaaac ttccccagac tctgcgagga aacggaaagg attgttgcta     1560

accacattcg tgagcgagaa gggaagacaa aggaccaggt attgctattg attgacattc     1620

aagtctctta catcaacacc aaccatgaag acttcattgg cttcgcaaat gctcagcaga     1680

ggagcagtca ggttcacaag aaaaccacag ttggaaatca gggaaccaat cttccgcctt     1740

caaggcaaat tgtgattcgc aaggggtggc tcaccatcag caacattggc atcatgaaag     1800

gcggctcgaa gggatactgg ttcgtcctta ctgcggaaag cttgtcctgg tataaagatg     1860

atgaggaaaa agaaaagaag tacatgcttc ccttggacaa cctgaaagtt cgggatgtgg     1920

aaaagagctt tatgtctagc aagcacatct ttgcactctt taatacagag caaaggaatg     1980

tatacaaaga ctatcgcttc cttgagctgg catgtgattc ccaggaggat gtcgacagct     2040

ggaaggcatc tctactaaga gctggggtct atcctgacaa atctgtaatg aacaaaaaag     2100

ctgaaaatga tgagaatgga caagcagaaa acttttccat ggacccacaa ttggagaggc     2160

aagtggagac cattcgcaac ctcgtagact cctacatgtc cattatcaac aaatgtatcc     2220

gagatctaat tccaaaaaca ataatgcacc ttatgatcaa taacgttaaa gatttcataa     2280

attccgagct cctagcacag ttgtattctt cagaggacca aaataccctg atggaggaat     2340

ctgctgagca ggctcagcgc cgggatgaga tgcttcgaat gtatcaagca ctgaaagaag     2400

cccttgggat aattggggac atcagcacag ccaccgtgtc cactccggca ccccctccag     2460

tggatgactc ctggatacag cactctcgca ggtcacctcc tccaagcccc acaacccaaa     2520

ggaggccaac actaagtgct cccctcgcaa ggcccacatc cggccgagga ccagctcctg     2580

ccattccctc tcctggcccc cactctgggg ctcctccagt cccattccgt ccaggcccat     2640

tacctccttt ccccagcagc agtgactcct tcggagcccc tccacaagtt ccatctaggc     2700

ctacgagggc cccgcccagt gtcccaagcc ggagaccacc cccatcacca actcgtccca     2760

ctataatccg cccactagaa tcctccctgt tagactaaac gaagtgtctg gcatggcaat     2820

taatcactaa tgaattatgc gaaagcaaca tatttgataa ccgttgcagt aaatcatgag     2880

tagtcgcatg tgtggacatc agtaggcaag taaccagttt tactaatgca ttcatcgctc     2940

atcttcattg ctcatggtat gtcaaacctt tggggtttga ctcagaaact gctaaccttt     3000

tagaggcttt atatgttgta ctgaccaagg taggtttgta tagcagccct atactttggg     3060

gatcatttgc ctaccatggc atatatttga aattgctttg gacaagtttt ctaggctatc     3120

taccaggtag ctcattaaac gtaattcttc agatatgaga tagtgggctt agacctaagc     3180

catacatatt tcttttccca cattctgttt aggatgacag taattctgtt gtctaccatt     3240

aatgctacta cctactccat aattgcctat ttagctcctc ttttcttcct ttttatttca     3300

taagactgct aggaagtgat tttttaaaat taggactcct taagaataaa cttttccaga     3360

agcacgaggt agtttgcaaa ggaaaagtct gcactgtttg ctctaaagag cttctcctca     3420

ttccaatgtg ttttgcttca tgctagaagc atatgcaaca gtgaataaaa gcttcttttt     3480

ttgttaatca gtcaataaat ttggctaatt agtttcagag ttcaaggaag aagcaaaata     3540

tcacatctct agaagtgttg ggaaaaatat aatttctttc tttacttata ttcacctcat     3600

ggtaggttat attgaaggct gacatggaga atgtttactt ttctatttgg catagctaac     3660

tacactttga tactaactcc agttttacta ttattatttt ggttggaaaa aaaattcact     3720

ctttacgtgc taatttgtaa tcttgttttg taagaattta tcctaccctt gaaacaggct     3780

cagtgtaact gtatatccat tctaggcttt cttaataaat cttgaggcta tgggataatc     3840

acatttaaag aatggttcct gaaatgaagt cagtagaaat ggcatgggat aagagcagag     3900

ctcacacttt tacagttgca gtatttcaaa gtccctatcc aggtcactcc agaaaagggt     3960

attgaaacgt tgaaatctaa agcaaatttg caatttctta agatttctaa aatttaccag     4020

aacagtttag cctgggggtt aatagttaag tcttgaggct aagttttgga ctaccaagga     4080

ccagatgatt cacatgtagg aaacagccag aagccaactg gaattttgtg tgctaactgt     4140

tcccagacag cagagcaagt attcactgag taggggtgtc ccatgacact atttcatatt     4200

ctacagaagt aaatcaggtt tcaccaactg aaatgtctcc ctttgaaagt agcaaacatg     4260

atttgtatgt taacttaact ttaatttcct gtgtagttta cacccagagc agatactcat     4320

aaagtataaa gtaaaaactt ttaaccatta ttaaacagag aacttgccat gttgagtgcc     4380

attgtattga acttattcta aaggcttatg ctaacccatt tataattggt aaaaatcaga     4440

aaatacaaga tttacataaa ggtcatttca acttttaagg ttaccagtga ttgtataaaa     4500

acatcacaat cctaaatcct ctcgtatctc accccaaacc ccaaactggg ggaaaaaaag     4560

ttaactcttt gtgaatggaa ccaatgtgca agatacatac tgcattttta aaatagtgtc     4620

tcagctaaat ggaaaactgt taagcaaaca tccatagtaa aacaaataat cttcagtgag     4680

atctttttat aaaacttctt gtttttagga ttccctttgc ttcttccttt gaattctcta     4740

aaataggcag ctaacggatt atatacttca gggtttggct ttgtgctaaa tgtggttttg     4800

tgttttgctg tatttcaaaa ttttccttct gttaaaggaa aatattgtga ataaccactg     4860

gtgtgttctt agatcagcac aaaccatgtc aaaaaaaatt ggagattttt ttccaatttt     4920

ccttccactg atcttaggca gtaataaaca atggcatttg tcatctttgg cacttgcttt     4980

tagattatag tcccacagtt gcactgcccc aattgtctac ctttgtgggt acatttttgt     5040

tctttactcc taagttattt ctcatagaac ccagcctact ctagaatttc agcagtgaca     5100

ttggagaata tttttaattt gctgcagtac tatgtcatat tattagtatg aatctcattt     5160

cccaaagggt ttgtattctg ctaaaaggag atgccaatgt tgaatgaagt ctgaaactct     5220

agtatgtgca tagtttgacg tgcagcatgc acaccaggcc ttaagatggg aatgtagctt     5280

aatgattttc tgtttcccat accatttcta atcttttgtg taattttctc ttaactgatt     5340

gctctgatat tgtaaacaca atagatgtag ctctatcatg tctagcataa tttaaaaaat     5400

cagtgttttt aggatttggg aaaataaact gtaaatgttt atttgatagg taaatatagt     5460

tttattgtca catgctaaat attgcatgca tattgactaa ttggaataac catttactca     5520

attatggaca gcttattgaa atagtattga tttagaaaaa gtatattgca tttctaaaaa     5580

acatctacca aggttactcg tctgaatatt gcttttagcc gtgttttata acatagacga     5640

gcagtagggt ctgtttatta gcaaatttcc tatttgttcc aatacaaact cactttattc     5700

taaagtatat taatgaaacc agttcctgtg atgtaactgt aagccttctc gacttagact     5760

taaaaagtgg tcacatagat taattttgtg actttttagt atagactgta gccataattc     5820

tcaaatatga aatgggacct aataccagta tgtgataaat gttgatgttt tctgtgtaca     5880

aacacatttt ctatgcatgt gtctctgtgt atatggcata tacctagtaa gtatgtttct     5940

gtaagtatgt gtattttatg tccatttgag taggtaggta ggttttaaaa atactagtta     6000

aaatgccaca agcatgagtg tgattgtatg tgcactgtgt gtatatatat aaatatatgt     6060

atatgtatgg ttgtaaatat ctatgtatac atgtacttag tatgtgtggt atcaggatat     6120

tttttaaact gtgataatac aacagatagc tttgaatgat ctgccataac atgtggtaac     6180

aatagttcat ttctcataac atatatgagg tatacaaaat tttctaactc cagattgtag     6240

tcattttgag aggtacaaag ctcataatta ccatgacaac atggtaatgt ccatagacat     6300

ttgtatctga atccacaaga agatctgaat ctaagaagga attacctttg acaatatttt     6360

tcggtaagaa gtaaaacctc tggagaccta tctttaagat ctctaattgg aattataaat     6420

tatttttgga ttgctgagct gaatcttaaa aagccaagtt gatatacata gtcatttttc     6480

ctctatggta gaagtaaaaa aaaaaaaaaa ggacatagca acattaaagt agtggatttt     6540

tctgagtaaa tttgctgaaa atataagaga gaagctatct aataccttgg aggtaggtca     6600

tccacttttt caggtaaaca tttttcattt ggcaaatggc ataattattt gaaagtgaca     6660

ggaatctcct cagaatgaag aataaagcct actaggtctc taactgttga actcatgaaa     6720

gaagatagtg tatgagactt aagccatgag ttttgtatca tttcaattag aagactacta     6780

gctgtgagct cagagtttaa tgtaaatgaa tctagatgat tttgaagaaa tgattattcg     6840

ttcaccagat cactcattgt acattctaaa aagctcaaat gagtcttcta gatactctta     6900

ctcatcctgt ctggttgcta tgtttaaaat tatgtggtgc tgtgtaggtg aaactttaag     6960

aatatttttg aagcatatgt aatatatgca ctgctatttg tgtgtgtgtg tgtgtctttg     7020

tatatatgta agaatgtgtg tatgtgtgag agcaagagag aggaaactca aagaggagtg     7080

tttgtcttaa gacctgttca tactggtata ttggtgagac ttctcacttc tggttggagg     7140

tttcacatat ggctcaactc aagtcattaa tctcttttta atttttactc ttgaattcct     7200

taaacttcgc tcattatgaa atgttttaaa attatgacaa aaattactct gtctaaccac     7260

ttgccttgtc tgctaccagt ttgttaaaaa ttattccccc caaccagtaa ttccaccagt     7320

actacttgat ttgtgttata tttcctatgt acatgtacag cctttgtttt gcttgcttgt     7380

ctatttttac tttccctttt ttgggtcaaa tttttctttt gctttgtttg aagaaggaat     7440

atacagaagt aaaatcttgt cttctctgct gattctttaa ttaatatgag ccggatactt     7500

tccactgtct tcttggcact ttcaggattt cttaatgctg atatatggac tcttagaatg     7560

gaatttttga agaaaaatct caaagcctgt atcgttcttg aaggtcacat gtacctattg     7620

tgaaaatgtg aagctgtatt tctgaagctg aaataaatta taacatttga agg            7673


<210> 1455
<211> 6379
<212> DNA
<213> Homo sapiens

<400> 1455
gccacaggga cagccggtgg gctcggtggg gctgcagaag gtcggggctg cactgctctc       60

ggcccccaca cggttggttg gttggcgtgg taagtgccct gatccctggt cctgagaact      120

caggctggca cagggattcc cagggcatct accaccacgc agctggagca gggctgagcc      180

caggagcatg gagatggacg cccccaggcc ccccagtctt gctgtccctg gagcagcatc      240

gaggcccggg agggctgcca tcagcagcag tgagccatca cctctgctgg ccacattgtg      300

ttttttctcc tagaactgtg gacaacggaa ggctgagccc catccattga gttcctgggg      360

ccccactgga ggggctgctg tggccagggt gcacggtcac aaatgaagac accaaggcgc      420

agagaggtga ctcagcctgc cctcagtcac ctatctgctc ctggaggtga tccccgactc      480

catgaggaag caagaggtgc ggacgggcag ggaggccggc cagggccacg gtacgggctc      540

cccagccgag caggtgaaag ccctcatgga tctgctggct gggaagggca gtcaaggctc      600

ccaggccccg caggccctgg ataggacacc ggatgccccg ctggggccct gcagcaatga      660

ctcaaggata cagaggcacc gcaaggccct gctgagcaag gtgggaggtg gcccggagct      720

gggcggaccc tggcacaggc tggcctccct cctgctggtg gagggcctga cggacctgca      780

gctgagggaa cacgacttca cacaggtgga ggccacccgc gggggcgggc accccgccag      840

gaccgtcgcc ctggaccggc tcttcctgcc tctctcccgg gtgtctgtcc caccccgggt      900

ctccatcact atcggggtgg ccggcatggg caagaccacc ctggtgaggc acttcgtccg      960

cctctgggcc catgggcagg tcggcaagga cttctcgctg gtgctgcctc tgaccttccg     1020

ggatctcaac acccacgaga agctgtgtgc cgaccgactc atctgctcgg tcttcccgca     1080

cgtcggggag cccagcctgg cggtggcagt cccagccagg gccctcctga tcctggacgg     1140

cttggatgag tgcaggacgc ctctggactt ctccaacacc gtggcctgca cggacccaaa     1200

gaaggagatc ccggtggacc acctgatcac caacatcatc cgtggcaacc tctttccgga     1260

agtttccatc tggatcacct cccgtcccag tgcatctggc cagatcccag ggggcctggt     1320

ggaccggatg acggagatcc ggggctttaa cgaggaggag atcaaggtgt gtttggagca     1380

gatgttcccc gaggaccagg cccttctggg ctggatgctg agccaagtgc aggctgacag     1440

ggccctgtac ctgatgtgca ccgtcccagc cttctgcagg ctcacgggga tggcgctagg     1500

ccacctgtgg cgcagcagga cggggcccca ggatgcagag ctgtggcccc cgaggaccct     1560

gtgcgagctc tactcatggt actttaggat ggccctcagc ggggaggggc aggagaaggg     1620

caaggcaagc cctcgcatcg agcaggtggc ccatggtggc cgcaagatgg tggggacatt     1680

gggccgtctg gccttccatg ggctgctcaa gaagaaatac gtgttttacg agcaagacat     1740

gaaggcgttt ggtgtagacc tcgctctgct gcagggcgcc ccgtgcagct gcttcctgca     1800

gagagaggag acgttggcat cgtcagtggc ctactgcttc acccacctgt ccctgcagga     1860

gtttgtggca gccgcgtatt actatggcgc atccaggagg gccatcttcg acctcttcac     1920

tgagagcggc gtatcctggc ccaggctggg cttcctcacg catttcagga gcgcagccca     1980

gcgggccatg caggcagagg acgggaggct ggacgtgttc ctgcgcttcc tctccggcct     2040

cttgtctccg agggtcaatg ccctcctggc cggctccctg ctggcccaag gcgagcacca     2100

ggcctaccgg acccaggtgg ctgagctcct gcagggctgc ctgcgccccg atgccgcagt     2160

ctgtgcacgg gccatcaacg tgttgcactg cctgcatgag ctgcagcaca ccgagctggc     2220

ccgcagcgtg gaggaggcca tggagagcgg ggccctggcc aggctgactg gtcccgcgca     2280

ccgcgctgcc ctggcctacc tcctgcaggt gtccgacgcc tgtgcccagg aggccaacct     2340

gtccctgagc ctcagccagg gcgtccttca gagcctgctg ccccagctgc tctactgccg     2400

gaagctcagg ctggacacca accagttcca ggaccccgtg atggagctgc tgggcagcgt     2460

gctgagtggg aaggactgtc gcattcagaa gatcagcttg gcggagaacc agatcagtaa     2520

caaaggggcc aaagctctgg ccagatccct cttggtcaac agaagtctga cctctctgga     2580

cctccgcggt aactccattg gaccacaagg ggccaaggcg ctggcagacg ctttgaagat     2640

caaccgcacc ctgacctccc tgagcctcca gggcaacacc gttagggatg atggtgccag     2700

gtccatggct gaggccttgg cctccaaccg gaccctctcc atgctgcacc tgcagaagaa     2760

cagcatcggg cccatgggag cccagcggat ggcagatttg aagcagaaca ggagtctgaa     2820

agagctcatg ttctccagta atagtattgg tgatggaggt gccaaggccc tggctgaggc     2880

cctgaaggtg aaccagggcc tggagagcct ggacctgcag agcaattcca tcagtgacgc     2940

aggagtggca gcactgatgg gggccctctg caccaaccag accctcctca gcctcagcct     3000

tcgagaaaac tccatcagtc ccgagggagc ccaggccatc gctcatgccc tctgcgccaa     3060

cagcaccctg aagaacctgg acctgcagtg gaacttcatc caggccggcg ctgcccaggc     3120

cctgggacaa gcactacagc tcaacaggag cctcaccagc ttagatttac aggagaacgc     3180

catcggggat gacggagcgt gtgcggtggc ccgtgcactg aaggtcaaca cagccctcac     3240

tgctctctat ctccaggtgg cctcaattgg tgcttcaggc gcccaggtgc taggggaagc     3300

cttggctgtg aacagaacct tggagattct cgacttaaga ggaaatgcca ttggggtggc     3360

tggagccaaa gccctggcaa atgctctgaa ggtaaactca agtctccgga gactcaatct     3420

tcaagagaat tctctgggga tggacggggc gatatgcatt gccacagcac tgtctggaaa     3480

ccacaggctc cagcatatca atctccaggg aaaccacatt ggggactccg gggccaggat     3540

gatctcagag gccatcaaga caaatgctcc cacgtgcact gttgaaatgt gatcctggtg     3600

gacggatcag gagaatgggc agatgctcag ctggaagctt ttgaacagaa aggccgactt     3660

ctggggggcc tgtctgggag ctgggaacgc tgcttgctca gcacgagagc cgggctctgc     3720

agggaggaag gagaggtgct gccggaggag gtcgtgagct cctcttctgc tgcaggagtg     3780

gtccaggcag ggggtgacgg gtactctgtt atggcacaga gaagggaggg gccaccccca     3840

agggactagg ggccaaaggc ctgaaagctg agcagtacag gaggctggtt ccagctttac     3900

accctgagga cttcatgtgt ccccaacctt taaaaatgtt tattactgcc cctttccact     3960

cacctggtta aaaatcatcc catgctctga gatgagctgc cacctcaagc ccgtgaggag     4020

catccgtttg gtaggggtaa cagaggggac ccttctttat cttctcaaga agaagatttc     4080

agggtatcat ccttacagac atgaaaaagc tatgggaaaa ttgtgaagat aaatgaaagt     4140

tttaattcta ggattctgga aacagagaca gtaagagttc tccaaggatt ttgccttttt     4200

tgtttgtttt tgagatggag tctcgctctt gtcgcccagg ctggagtgca gtggcacgat     4260

ctcagctccc tgcaacctcc gcctcccggg ttcatgtgat tctcctgcct cagcctcccc     4320

agtagctggg aatacaggca cccgccacca tgcccggcta atttttgtag ttttagtaga     4380

gacggggttt catcatgttg gccaggctgg tctcgaactc ctgacctcag gtgatccatc     4440

agcctgggcc tcccaaagta ctgggattac aggcatgagc caccacacct ggccccattt     4500

tttatttatt acaaaatcaa agacatgggt gatgcctggc acatgttgtc tggagtctgg     4560

cacactggtt atcaatagca cattcagtgt attcagtgat gtcattcttt atttattttt     4620

gagacagaat ctgtcaccca ggctggagtg cagtggcatg atctcagctc actgtaggct     4680

ctacctcatg ggttccagtg attctcctgc ctcggcctcc caagtagttg ggtctacagg     4740

cacgcaccac cacacccagc taatttttgt atttttagta gagatggggt ttcaccatgt     4800

tgatcaggct ggtctttaac tcctgacctc aagtgatcca cccacctcag cctcccaaag     4860

tgctgggatt acaggtgtga gccactgcac ctggcagtga tgtcattcct tactaggctt     4920

ccaaagccac tgctgtggcc acagcttcca tggagacagg caagctgagc ctctatgtgg     4980

caccaattcc tgcagctgtt tgtgttggag ggaaaaaaat ccaaatggac atcaacagct     5040

ttcatcaact aaataaccac agaaaatatt tatgaagact ataaagcaat gattactttt     5100

gaattggaaa ggaatcacta ttatttgaaa tgtttcttca aaagtgagca tccggacagg     5160

aaccatcatg gatgctgagg ccatggatga aggcctactc gggaagatga tatccttgca     5220

gtctcaaaac ggcaccccac aaaggtgata tcctaattta caaagggaaa aaggtacctt     5280

aatctgaaat ctggcaaatg cagcctcaac agaagtgaca gaattgaaca tcgccaataa     5340

tgggacacac agacatcaca tgcccccagt ctgatgcacc acggagtcgt ctctgatgta     5400

ttcttgtcaa aaaatgtttg cctgattcta atcatgaaag aacaattaga aaaaatccaa     5460

attgacagat attctgcaga ataaatggcc tgacctcatc aaaaacatca atgtcatgaa     5520

aaacacaaaa cattgcagat agcgtgaaat taaagattac agagatataa tttaatgcaa     5580

gatctctgac tggatcctag actgcaggaa aaagtctgct ataaagaaca tttggatcac     5640

ttgtagtagc tgggaaataa aacaaaacat tatttgtaaa aggggggaaa tctgaacatg     5700

ggtcttgcag tatttatgac agtttttgcg gggcagagat ttctagattg acagctgttt     5760

tagtactttc aaggtgatgc tctgtctgct ggtttgcatt gtttctgtct gagttaagag     5820

actggcagaa cacagagttg cagtagccaa acactggaga aagctgggcc ctacagaaac     5880

ctaacgctga agaaacctca ggagccaaac tggtggagaa aacaaagagt cctccctctc     5940

tcccttttca aataatgatc atacatcttc aagctgtctg aaatggttaa ggagttcagt     6000

ctgtcgtcag gcacacacca gagccagcta gcccacacag accccatcag agcaaaacag     6060

acaagagaat ttaattcata tccacataga aaggacttct aggtaggagg tagacccttt     6120

agctcccttc caattaaagg agtccccaat tctggcacct gagagtcccc tgggtctaac     6180

agctatgata tttatgtagt gtgttgctta cctaaatgaa tacaatttcc ttccagacac     6240

gtgacactga tattaaagtg ctaatgagag ggatctattt cttcttgtac gctaaaagag     6300

aaacagcagt tcagatttcc catcagaagt ccgaggactt tgttcttgat aactactacc     6360

aataaaaatt gagtatttg                                                  6379


<210> 1456
<211> 4030
<212> DNA
<213> Homo sapiens

<400> 1456
ggagcgcgtg cccgtgcgcc gccgccgcca ttttggagcg atcggagtgc cgcccgcggc       60

cccgagtcgg tctcgagccg ccggccggcc gtgccggtgt ccgtaggcgc tgcgccctcg      120

gccgggccca tgtgtgtgcg gcccgcccga ggccgcccgg gctttgcctc caccagcgcc      180

ctggcctccg ctcgggcctc cacacgggcc tccgaagagc tgccgcgacg cccggcccgc      240

agggcaggta aagagattat aaatcttcca ctgaatgaaa aaaattttct taaagctgca      300

tatactccaa gaaaaaaacc acaaatgttt ttctgttttg cctgaataca tgatttaaac      360

aagagatttc cacagaagct ctgcggccgt cacgatgttc tggaagtttg acttgaacac      420

cacgtcccat gttgacaagc tgctggacaa ggagcatgtg acgctgcagg agttaatgga      480

tgaagatgac atcttgcagg agtgtaaggc tcagaaccag aagctgctgg acttcctgtg      540

caggcagcag tgcatggagg agctggtgag cctcatcaca caggatccgc ccctggacat      600

ggaggagaag gtccgcttca aatatccaaa cacagcctgt gagcttctga cttgtgatgt      660

gccgcagatc agcgaccgcc tcggtgggga cgagagcctg ctgagcctcc tgtacgactt      720

cttggaccat gagccgcctc tcaatcctct gctcgccagt tttttcagca agaccattgg      780

caatctcatt gcaagaaaaa ccgaacaggt gattacgttt ttgaagaaga aggacaagtt      840

catcagcctg gtgttgaagc acatcggcac ctcagcgctt atggacctgc tgctgcgcct      900

ggtcagctgt gtggagccag ccgggctccg gcaggacgtc ctgcactggc tgaatgaaga      960

gaaggtcatc cagaggcttg tggagttgat ccacccgagc caggatgaag ataggcagtc     1020

aaatgcttct cagactctct gtgacatagt taggctgggc agagaccagg gcagtcagct     1080

gcaagaggct ctggagccag acccgctcct cacagcgctg gagtcgcagg actgtgtgga     1140

gcagcttctg aagaacatgt ttgatggaga ccggacggag agctgcctcg tcagtgggac     1200

tcaggtgtta ctcaccttgc tggaaaccag gcgggttggg acagagggct tggtggactc     1260

cttttctcag ggactggaaa ggtcatacgc tgtcagcagc agcgtactac acggcatcga     1320

gcctcggctg aaggacttcc accagctcct gctcaacccg cccaagaaga aagcgatcct     1380

gaccaccatt ggtgtgctgg aggagcccct ggggaatgcc cgtctgcatg gcgcccgcct     1440

catggcagca ctgctgcaca caaacacacc cagcatcaac caggagctct gccggctcaa     1500

cacgatggac ttactgctgg acttgttctt taagtacacc tggaataact ttttgcactt     1560

ccaagtggaa ctatgcatag ccgctattct ctcccacgct gcccgtgagg agaggacaga     1620

agccagcgga tccgagagca gggtggagcc tccgcatgag aacgggaacc ggagcctgga     1680

gactccccag ccggccgcca gcctccctga caacacaatg gtgacccacc tgttccagaa     1740

gtgctgcctg gtgcagagga tcctggaggc ctgggaagcc aacgaccaca cgcaggcagc     1800

gggtggcatg agacgtggga acatgggcca cctcacacgg atcgccaacg cggtggtgca     1860

gaacctggag cggggccctg tgcagacgca catcagcgag gtcatccgag ggctccctgc     1920

ggactgccgt ggccgctggg agagcttcgt ggaggagacg ctgacggaga cgaaccgcag     1980

gaacactgtg gacctggcct tctctgacta ccagatccag cagatgacag ccaacttcgt     2040

ggatcagttt ggcttcaatg atgaggagtt tgccgaccag gacgacaaca tcaatgcccc     2100

gtttgacagg atcgcagaga tcaacttcaa catcgacgct gacgaggaca gtcccagcgc     2160

agctctgttt gaggcctgct gcagtgaccg catccagccc tttgatgatg atgaggacga     2220

ggacatctgg gaggacagtg acactcgctg tgctgcccgg gtgatggcca gacccaggtt     2280

tggagccccc catgcttcag agagttgctc aaagaatggc ccagagcgtg gaggccagga     2340

tgggaaggcg agcttggaag cacacagaga tgcacctggg gcaggtgccc caccggcccc     2400

cgggaagaag gaagcgcccc ctgtggaggg tgactcagaa gcaggcgcca tgtggacggc     2460

agtgtttgat gagccagcga actcaacgcc cacagcccca ggagtggtga gggacgtggg     2520

ttccagtgtg tgggcagctg gcacctcagc tccagaggag aaaggctggg ccaagttcac     2580

tgacttccaa cctttctgct gctccgagtc agggcccagg tgcagctctc cggtggacac     2640

agaatgcagc catgctgagg gcagccggag ccaaggccct gagaaagcct tcagcccggc     2700

ttctccatgt gcctggaacg tgtgtgtcac caggaaggcc cccctgctgg cctctgacag     2760

tagctcctct gggggctccc acagcgagga tggcgaccag aaggcagcga gtgccatgga     2820

tgcggtgagc aggggtcccg gccgggaggc ccccccgctg cccacagtgg ccaggacaga     2880

ggaggctgtc ggcagggtcg ggtgtgctga cagccggctg ttaagccctg cctgccccgc     2940

gccaaaggaa gtgactgctg ccccagccgt ggctgtgccc cccgaggcta ctgtggccat     3000

caccacagca ctgagcaagg ctggccccgc catacccacc ccagcagtct cttctgcact     3060

ggccgtggcg gtccccctag ggcccatcat ggcagtcaca gcagccccag ccatggtggc     3120

caccctgggg acagtgacaa aggacggaca gatgccccgc cagaaggagc tgccttaaat     3180

ggcccagtgt gatgctgctg ccgcccggcc acggcccacc ctggtcaggc tgcctcctta     3240

atcgagaaaa ctacctggtg atgcaatctt tttttttttt aatttaattt aattttaaaa     3300

taaatgctgc attggtaaag ctggcagttg aaaccagttg gacggcccag cttgcgtctc     3360

ttctgcctga gtgggcctct caggtcactc gtgccctgct ggaggacaga ggggcacctc     3420

agccgccccc aagcccagag cacagcaata aggtcggcct gcaggagccg gggtgggggt     3480

gggggtgggg ggggcaggac cctgagatgc caccaggacc tgatgggcca ggaagggcgt     3540

ggacatggag gctgttttta cagttttttt tttgttgttg ttttgttttt aaagaataca     3600

gaaggagcca agcttttttg cactttgtat ccagctgcaa gctcagggca gagtcaaggg     3660

cctgggttgg aaaaacctga ctcacaggaa tgcataattg acccttgcag ctacccaata     3720

gcccttggag ctggcactga accaggctgc aagatttgac tgccttaaaa acacaaggcc     3780

ctctaggcct ggcagggatg tccctgtgcc cagcacaggg tgcctggcag ggggagacca     3840

caggtatgca ggtgggggga catggtgtgg cactaggggc tcgaagactg gtttctagca     3900

ctaccggtca cggccatgtc gtcctagaag ggtccagaag attattttac gttgagtcca     3960

tttttaatgt tctgatcacc tgacagggca ccccaaaccc ccaactccca ataaaagccg     4020

tgacgttcgg                                                            4030


<210> 1457
<211> 2690
<212> DNA
<213> Homo sapiens

<400> 1457
gtagggtggg ggtgctggcg gcggctgctt tggcggcggt tggtggccgt gcgggcgggg       60

agggaggggg aggagagaag aggaggtgga gaaggcttgg gctcgcgccg ctgaagtcgg      120

cttacccgct ggccgcctcc tgacaagcgg gagggatccg cggtggaccc agggaagcgg      180

aggagcctgg cggccacccc ctcttcctca cttccctgta ctctcatcgc tctcggcctc      240

cgacacgttc caagatgaga tgggattctc caacatggaa gatgatggcc cagaagagga      300

ggagcgtgtg gctgagcctc aagctaactt taacacccct caagctctac ggtttgagga      360

actactggcc aacctactaa atgaacaaca tcagatagcg aaggaactat ttgaacagct      420

gaagatgaag aaaccttcag ccaaacagca gaaggaggta gagaaggtta aaccccagtg      480

taaggaagtt catcagaccc tgattctgga cccagcacaa aggaagagac tccagcagca      540

gatgcagcag catgttcagc tcttgacaca aatccacctt cttgccacct gcaaccccaa      600

tctcaatccg gaggccagta gcaccaggat atgtcttaaa gagctgggaa cctttgctca      660

aagctccatc gcccttcacc atcagtacaa ccccaagttt cagaccctgt tccaaccctg      720

taacttgatg ggagctatgc agctgattga agacttcagc acacatgtca gcattgactg      780

cagccctcat aaaactgtca agaagactgc caatgaattt ccctgtttgc caaagcaagt      840

ggcttggatc ctggccacaa gcaaggtttt catgtatcca gagttacttc cagtgtgttc      900

cctgaaggca aagaatcccc aggataagat cctcttcacc aaggctgagg acaatttgtt      960

agctttagga ctgaagcatt ttgaagggac tgagtttctt aaccctctaa tcagcaagta     1020

ccttctaacc tgcaagactg cccgccaact gacagtgaga atcaagaacc tcaacatgaa     1080

cagagctcct gacaacatca ttaaatttta taagaagacc aaacagctgc cagtcctagg     1140

aaaatgctgt gaagagatcc agccacatca gtggaagcca cctatagaga gagaagaaca     1200

ccggctccca ttctggttaa aggccagtct gccatccatc caggaagaac tgcggcacat     1260

ggctgatggt gctagagagg taggaaatat gactggaacc actgagatca actcagatca     1320

aggcctagaa aaagacaact cagagttggg gagtgaaact cggtacccac tgctattgcc     1380

taagggtgta gtcctgaaac tgaagccagt tgccgaccgt ttccccaaga aggcttggag     1440

acagaagcgt tcatcagtcc tgaaacccct ccttatccaa cccagcccct ctctccagcc     1500

cagcttcaac cctgggaaaa caccagccca atcaactcat tcagaagccc ctccgagcaa     1560

aatggtgctc cggattcctc acccaataca gccagccact gttttacaga cagttccagg     1620

tgtccctcca ctgggggtca gtggaggtga gagttttgag tctcctgcag cactgcctgc     1680

tatgccccct gaggccagga caagcttccc tctgtctgag tcccagactt tgctctcttc     1740

tgcccctgtg cccaaggtaa tgatgccctc ccctgcctct tccatgtttc gaaagccata     1800

tgtgagacgg agaccctcaa aaagaagggg agccagggcc tttcgctgta tcaaacctgc     1860

ccctgttatc caccctgcat ctgttatctt cactgttcct gctaccactg tgaagattgt     1920

gagccttggc ggtggctgta acatgatcca gcctgtcaat gcggctgtgg cccagagtcc     1980

ccagactatt cccatcgcca ccctcttggt taaccctact tccttcccct gtccattgaa     2040

ccagcccctt gtggcctcct ctgtctcacc cttaattgtt tctggcaatt ctgtgaatct     2100

tcctatacca tccacccctg aagataaggc ccacatgaat gtggacattg cttgtgctgt     2160

ggctgatggg gaaaatgcct ttcagggcct agaacccaaa ttagagcccc aggaactatc     2220

tcctctctct gctactgttt tccccaaagt ggaacatagc ccagggcctc caccagtcga     2280

taaacagtgc caagaaggat tgtcagagaa cagtgcctat cgctggaccg ttgtgaaaac     2340

agaggaggga aggcaagctc tggagccgct ccctcagggc atccaggagt ctctaaacaa     2400

ctcttcccct ggggatttag aggaagttgt caagatggaa cctgaagatg ctacagagga     2460

aatcagtgga tttctttgag ctaggagaat aagagtctgg agactgggag ccttcacttc     2520

ggcctccgat tggtggcgca tagggtgtaa ccaataggaa acccctaaag ggtacttaaa     2580

ccccagattt tgcaactggg gctcttgagc agcttgcttt agcctgctcc cactctgtgg     2640

aatatacttt tgcttcaata aatctgtgct tttattgctt cattgtttca                2690


<210> 1458
<211> 5723
<212> DNA
<213> Homo sapiens

<400> 1458
cggcaagcag gtctaggaat tcgcctggtt cccacctcgc gtcccttgcc ttccttccta       60

gtctacccac tgtagtgccc cctgcgtccc gctccctcct agccgactca gagcacaaga      120

aggattgcca cggtttccat tgcagcagcc gtggcgcctc tgaccctttt tttatatcgc      180

ggcgacggcg ggctgtcgtc acgacgacgt gcggacgcag cggcgggggc cttatgtgga      240

gaagtcgctg tgaagccacc tataaatcca tttactgaat ttatggagaa ggctgtaaat      300

gatggaagtc attcagaaga actcttttgc catcttaaaa ctatatcaga gaaagaagat      360

ttaccacggt gtaccagtga aagtcatctc agctgcctga agcaggacat tctaaatgaa      420

aagactgaat tggaagcaac acttaaggaa gcggagttgg taactcattc tgtagaattg      480

cttttgccac tatttaagga caccattgaa aagattaatt ttgaaaatgc gaatctttct      540

gcattgaatt tgaagatttc tgaacagaag gaaatattaa taaaagaatt agacaccttc      600

aaaagtgtaa aactagcttt agaacatctt cttagaaaga gagactacaa acaaacagga      660

gacaatttat ccagcatgtt gctagaaaat ctaactgata atgaaagtga aaatactaat      720

cttaagaaga aggtatttga aaaggaggcc catatccaag aactttcttg tttgtttcag      780

agtgaaaagg caaatacttt gaaagcaaac cgtttttccc aatcagtaaa agtagtacat      840

gaacgactac agatccaaat tcataaaagg gaagccgaga acgataagtt gaaagaatat      900

gtaaagagct tagaaaccaa gatagccaag tggaacctgc aatcaagaat gaataagaat      960

gaggctatag tgatgaaaga agcaagtagg caaaaaactg tagctttaaa aaaggcatct     1020

aaagtttaca aacaaaggct tgaccatttt acaggagcta ttgaaaagct tacttcccaa     1080

attagagatc aggaagccaa gttgtctgaa acaatttcag cttccaatgc ctggaaaagt     1140

cattatgaga aaattgtgat agaaaaaacc gaattggaag tacagattga aacaatgaaa     1200

aagcaaatca ttaatctttt ggaagatctg aagaaaatgg aagaccatgg aaaaaattca     1260

tgtgaagaaa ttcttagaaa agttcactca attgaatatg aaaatgaaac tctgaatctt     1320

gagaatacaa aattaaagct tagattccca tgtagaatta ctgagtcaaa gaatatgaac     1380

attttgattg ttcttgatat gctttgctac atttcttctg aaaagactac acttgctgct     1440

ttgaaggatg aagttgtatc tgttgaaaat gaactctcag aattgcaaga agtagaaaaa     1500

aaacagaaaa cccttattga aatgtataaa actcaggtac aaaagttgca agaagcagct     1560

gaaatagtaa aaagcagatg tgaaaatttg ctacataaaa ataaccaaat aacaaaaacc     1620

aaaaataaaa atgtagagaa gatgagaggc cagatggagt ctcatctgaa ggagttagag     1680

cgtgtctgcg attccttgac ggcggcggaa cggaggcttc acgagtgtca ggagagtctg     1740

cagtgctgca aggggaagtg tgcagaccag gaacacacca ttagggagct tcagggccag     1800

gttgatggaa atcacaatct tctgacaaag ctttctctgg aagaggaaaa ctgtcttatt     1860

cagctgaagt gtgaaaacct tcaacaaaaa ttagaacaga tggacgcaga aaataaagag     1920

cttgagaaga agctggcaaa ccaagaagaa tgtcttaagc acagcaatct taagtttaaa     1980

gagaaatctg cagagtatac agcattggcc agacaactgg aagctgcttt agaagaagga     2040

agacaaaagg ttgctgaaga aatagagaaa atgtcatcta gagagagtgc tttacaaatt     2100

aaaatattag atctggaaac tgagcttaga aagaaaaatg aagaacaaaa tcaacttgtt     2160

tgcaaaatga acagtgatcc agagactcca tgaaatctat ttttttaatt cccaagtgtc     2220

taaaaagttg aaaacctaaa agattcaaga gttaaatgat ttttggcatg cacaatttga     2280

ttttattgcc atcaaaagtt tcatgacaac ttagtcagaa caaaacgtcg atcaccttta     2340

atttagcaca ggccttccat ttatttctaa actttttttt aactcaccat ttgactttct     2400

gatattgtaa aatgtgtgtg ctgttttttt gtgtaattga agcctctgaa aaaataaatg     2460

aggtgggttt tgctgtaatg tccctagtac ttggctaaag ctagtaaaat aaatagatcc     2520

cattcacaat tgccacaaag agaataaaat acctaggaat ccaaattaca aggaatgtga     2580

aggacctctt caaggagaac tacaaaccac tgcttaagga aataagagag gacacaaaca     2640

aatggaaaac attccatgct tatgaataag atgaaacaag atcatgaaaa tggctatact     2700

ccccaaagta atttatagat tcagtgctat ccccatcaag ctaccattga ctttcttcac     2760

agaattagaa aaaactactt caaatttcat atggaaccaa aaaagagctc acataaccaa     2820

gacaatccta agcaaaaaga acaaagctgt aggcatcacg ctacctgact tcaaactata     2880

ctacaaggct acagtaacca aaatagcatg gtactggtgc caaaacagat atatagacca     2940

atggaacaga acagaggcct cagaaataac tccacacatc tacaaccatc tgctgtttga     3000

catacctgag aaaaacaaga aatggggaaa ggattcccta tttaataaat ggtgttggga     3060

aaactggcta gccatatgca gaaaactgaa actggatccc ttccttacac cttatacaaa     3120

aattaactca agatggatta aagacttaag tgtaagacct aaaaccataa aaaccctaga     3180

ggaaaaccta ggcaatacca ttcaggacat aggcatggac gaatacttca tgactaaaac     3240

accaaaagta atggcaataa aagccaagat tgacaaatgg gatctaatta aactaaagag     3300

cttctgcaca gcaaaagaaa ctatcatcag agtgaacagg aaccgacaga atgggagaaa     3360

atttttgcaa tctatccatc tgacaaaggg ccaatatcca gaatctacaa agaacttaaa     3420

caaatttaca agaaaaaaaa ccccatcaaa aagtgtgcaa agaatatgaa cagacacttc     3480

tcaagagaag acatttagtc agccaaaaaa catatgaaaa aaagctcatc actggtcatt     3540

cagagaaatg caaatcaaaa ctacagtgag ataccatgtc acaccaatta gaatggtgat     3600

cattaaaaag acaggaaaca acagatgctg gagaggatgt ggagaaatag gatgctttta     3660

cactgttggt gggagtgtaa attagttcaa ccactgcgga agacagtgtg gcgattcctc     3720

aaggatctag aaccagaaat accatttgac ccagcaatcc cattactggg tatataccca     3780

aaggactata aatcatgctg ctatagagac acatgcacac gtatatttat tgtggcacta     3840

ttcacaatag caaagacttg gagccaaccc aaatgcccat caatgataga ctgaataaag     3900

aaaatgtggc acatacacca tggaatacta tgcagccata aaaaaggatg agttcatgtc     3960

ctttgcaggg acatggatga agctggaaac catcattctc agcaaactaa cacaagaaca     4020

gaaaaccaaa caccgcatgt tctcactcat aagtgggagt tgaacaatga gaatacatgg     4080

atacagggca gggaacatca cacaccaggg cctgtcaggg cgtggggggc taggggaggg     4140

ataacattag aaattcctaa tgtagatgac gggttgatga gtgcagcaaa ccaccatggc     4200

acgtgtatac ctatgtaacc aacctgtacg ttctgtacat gtatcccaga acttaaagta     4260

taataaaaat taaaaaaaat aaagatctga tgttttgtta aacctgataa gttttgtact     4320

agtaaaattc tagaattcta agcatagatt taaacattgc tgaaaaatga gtttgtgtgt     4380

tttatgcctt ccaggggaca gttaagtggg cagtatttat ttaatatacc tgcttcagcc     4440

ccatttgaat tgtaagcact ctgaaagcat gtctcatagt cgtctgtatc cctggtgtct     4500

cccacagtgc cctgcttacc tgcaggcctt tttgtatttt ctgtccaagt accctaatag     4560

ggtggtgcag aatggatgta cagatctgtg gatgacctca gcagcttaat ccaaggcacc     4620

cctcgggaag cctgaaatgt ctttgaagtc ttatgtatta tcctaaaatc cattgacatt     4680

ttatattcta ccctacaaaa taagtatgtg ttactatttt tctttccaaa ttgttgagta     4740

aaactcattg tattcatcct gtgactttgt actgcccagc ctagctcatt gttttttacc     4800

tgcctcattt cctgagctgg gcattgctca gtttcagaag gtatcaggtg tcattgaaca     4860

cctgatatga aggatgtaaa agttctctct tttctatcta ggtgtctata ttttaattgg     4920

aggctagatg atatttgcaa cctgtcttta tctaaagcat tgtcagtgaa ctcacctact     4980

taggaattca tatgcacctt agttaaaaaa aatgtattgt ggttttaaat tttttcctca     5040

accagtgtaa tatgaagaat tctttttatt ttttaagaga ttctaagaaa atgttcacat     5100

tatcaaaact agaattctat caacttttaa gacatttaat tattttggaa taaaatgtga     5160

atttttagac agaaaatggc aaaaactagt atgaaaatat atcatgttac atgtgaaatt     5220

atgacagttg ttaacctatt aagttaatca tgttaaatat gtaataattt ggggctaaat     5280

gaatgtatat tataaattat atcagtgaag atcaaccatg tgtgtgcttt aattattaat     5340

tttaaagagt gagctctaag aatgaacaca tcagatgtga gtattatttt aaaaaatcaa     5400

aaagaattat ctagttattg tatatatgtt tttaatatta tgactctggt cctttggaat     5460

gaatgctatt attgcttatc tgtatttttt tccttttttc tttagaaagc acaacatcag     5520

gaagtgtgtt tgaaagaagt acaaaatagt cttgagaagt cggaaaatca aaatgagagt     5580

attaagaatt atttacagtt tcttaaaact tcttatgtaa caatgtttga ataaattgtc     5640

aaatttattt tctctaagta gtagattttt attatgagtc taaaatgtga ttgggtaaaa     5700

aaataaatat actaccagtt aca                                             5723


<210> 1459
<211> 1113
<212> DNA
<213> Homo sapiens

<400> 1459
ctcagcgaag atggcggcag tggagaagcg gcggcaagcg gtaccaccgc cggccggttt       60

cacggacagc ggccgccagt cggtatcccg ggcggcgggg gcggccgaga gcgaggagga      120

cttcctgcgg caggtcggcg tgacggaaat gctacgtgcg gccctgctga aggtgctgga      180

ggcgcggccc gaggagccga tcgccttcct ggctcactac ttcgagaaca tgggcctgcg      240

ctcgcctgta aacggcggcg ccggggagcc cccgggccag ctcctgctgc agcagcagcg      300

cctgggccgc gcgctatggc accttcgcct ggcccaccac tcccagaggg ccgccttcaa      360

caacaacgtg agcgtggcct acgagtgcct gagcgccggc gggcgcagga agaggccggg      420

gctggacggg cgcacctaca gcgagctgct caggcgcatc tgccgggacg gccaagcccc      480

cgaggaggtg gtggcgccgc tgctgcgcaa ggtgcagtgc cgtgaccacg aggcggtgcc      540

gctgagcgtc ttccgcgcgg gcacactcac ctgcttcgtg ctgctggagt tcgtggcgcg      600

cgccggcgcg ctcttccagc tgctggagga ctcggccgcc gccgtggccg accgccgcgt      660

gggccaggcc gtgctggaca ccctggaggg cgcgctgcag gccagcgacg ccgccgcgcc      720

cgcgcgcttc ctggaggccg gctcgcgctt ggggcccgac agcctggcgc tggcgctgga      780

ccgcgccgtc ggggggcggc ggcccagcgc gcccatgacc cgcgaggagt ttctggagag      840

ggccgccgcg ctcttcatcg cgaaggtcaa gccggtgggc tgaggcccgt gggccgcgcg      900

gatccgggat ctgcgctggg gggtccccgc gtgcggggcg cgcggagcct tcccttcgcc      960

ctggtgaggc cctgccataa ccaggcgccc agccctgcgg aggaggccgg ggctcccagg     1020

aagcggacgc ccggtcccca cacagcgccg cggccgcccc tccacccccg cgggagcccc     1080

tgccccacgc taataaaatg tgttgcgagg ctg                                  1113


<210> 1460
<211> 2691
<212> DNA
<213> Homo sapiens

<400> 1460
gttcgtgcgt ggagcagtcg gggctggagg cgaggccgcc gggcgggcag gggttgtggc       60

gcggcaagcg gcgggccagc gacggcgcga atggcggact ctcagctgtt ctgtgtggcg      120

gaggaacgca gcggccactg cgccgtggtg gacggaaact tcctctacgt gtgggggggc      180

tacgtgtcta ttgaagacaa tgaagtatat ttgcctaatg atgaaatttg gacctatgat      240

attgatagtg ggttgtggag aatgcacctc atggaaggag aactcccagc ctccatgtca      300

ggaagctgtg gtgcttgcat taatggaaag ctgtacattt ttggaggata tgatgacaaa      360

ggatacagca atcgacttta ttttgttaat ttacgaacaa gagatgaaac ctacatttgg      420

gagaaaatca ccgactttga agggcaacca cctacaccac gtgataaact ttcctgctgg      480

gtatataaag acagactaat atattttggt ggttatgggt gtaggagaca cagtgaactc      540

caagactgtt ttgatgttca tgatgcatct tgggaagagc agatattctg gggatggcat      600

aatgatgtcc acatatttga cacaaagaca cagacttggt ttcaaccaga aattaaaggt      660

ggagttccac cacagccacg agccgcgcat acatgtgcag ttcttggaaa taagggttat      720

atctttggcg gacgtgttct gcaaactagg atgaatgatt tgcactatct aaacctagac      780

acctggactt ggtctggaag gattactatt aatggagaaa gcccaaaaca tcggtcatgg      840

catactttaa cacctatagc tgatgataaa cttttcctat gtggtggact aagtgcagat      900

aatatcccat taagtgatgg ttggattcat aatgtcacaa caaattgttg gaaacaactt      960

acacatttac ctaaaacaag acctaggtta tggcacacag cctgtttggg aaaagaaaat     1020

gaaataatgg tatttggtgg gagcaaagat gacttacttg ccttggatac aggtcactgt     1080

aatgatttat tgatctttca aacacagcct tattcactac tcaggtcatg ccttgactgc     1140

attggtaaaa attctatcat gttagaaagt cagatatctt tattacctcc taaacttctg     1200

caacaagtac tcaaaaaaat aacattttgg gctgcagcta atcaccgaga agaacaaaga     1260

gtccaaaaag aagaaacaga aaataaatat cagtggatca gtagcaatta aattgttata     1320

tactttacat atttagtatg ttttaacttt ttaatcagac tatacattta cactcccaaa     1380

ttgcaggctt tatttaaagg ataaaattta aaggataaaa aaacagtcac tctgttaagt     1440

gactatatgc catgggatat atggaaaaaa gatattaatg cagattaatt tatatttgta     1500

aacaaatttc cttacaaact gcagaacaaa tattctttct gaaagtaagt acagttataa     1560

cagattttaa atcaatgtgt attctttact ggaaagatta catacatttg agaataagaa     1620

attactctca agaacttcag aaatctgcaa cataatttta taaatatata aatacatgta     1680

tgtatgtcaa aacactacat atacactttc agaaagaata aactttctca agtcatttta     1740

aagttaccta acgttcttct tgaataacta atacagtggg tcaaatatta taaaataggc     1800

aaacaccaaa atggtattaa atattgaact cctgaccttt tcgacactta cctagtaaag     1860

tattcttagg catcatcata acttttcctc acctttattc gaatagagga ataaatgtct     1920

tcagttgtct ctccattacc cctaagttat tagtttgtct agtttatata taaagaccat     1980

gttttaaagt acataaagtg gaggtttatt tatcatacag gctttgaaac attaagaagc     2040

agtattttta ttaacttttt gagacatatt aaaatacatt ttgccttaga agactgcttc     2100

taaagtaatt tttgtaagta atgagatggg atggtaatct agtaatttga ctttatagaa     2160

atccctcagt ttggccccca ccattctaca gagttgtact caagacagat actgaaaaaa     2220

tctaatacct tcccttgtat tttcagcatt accatctata cagaaatgga acactgtatc     2280

tttatattcc taaaaatggt acttttggca taattaagaa atttttcttc atattatcac     2340

aatcatgccc ttccattgaa ttattaatta caattaatta ctaaaaagct tggtatgtaa     2400

aattattctc cacaatatta ccatgcaagt tatctctgaa atttaaaatg ttaaagaaaa     2460

acatttctat attgaaatat atataattta taatgaaaat tatagtagtt tgtagtattt     2520

cattgaattt tagagagata tttcatatat atgtactgta ttttggatgt gtaaagcttc     2580

tatgtattga aatatttttt tacgttttat ttattgtaca aagtgtatat aattactgtt     2640

ttcttttttg tcagtgtaaa gcagtcatta gaattgatta tacaaaaaat a              2691


<210> 1461
<211> 1409
<212> DNA
<213> Homo sapiens

<400> 1461
aacgagcctc tgactccagg ttatcatgga ttcccagcgc gggacagcca gggtaaccag       60

gagccgacaa caactcctga cgcaatggtt cagcctttta ctaccatccc atttccacca      120

cctccgcaga atggaattcc cacagagtat ggggtgccac acactcaaga ctatgccggc      180

cagaccggtg agcataacct gacactctac ggaagtacgc aagcccacgg ggagcagagc      240

agcaactcac ccagcacaca aaatggatct cttacgacag aaggtggagc acagacagac      300

ggccagcagt cacagacaca aagtagtgaa aattcagaga gtaaatctac cccgaaacgg      360

ctgcatgtct ctaatattcc tttccgcttc cgggaccctg acctccggca gatgtttggg      420

cagtttggca aaatcctaga tgtagaaata atctttaatg aacgtggctc taagggattc      480

gggttcgtaa ctttcgagaa tagtgctgat gcagacaggg ccagggagaa attacacggc      540

accgtggtag agggccgtaa aatcgaggtg aataatgcta cagcacgtgt aatgaccaat      600

aagaagatgg tcacaccata tgcaaatggt tggaaattaa gcccagtagt tggagctgta      660

tatggtccgg agttatatgc agcatccagc tttcaagcag atgtgtccct aggcaatgat      720

gcagcagtgc ccctatcagg aagagggggt atcaacactt acattccttt aatcattcct      780

ggcttccctt accctactgc agccaccacg gcagccgctt tcagaggagc ccatttgagg      840

ggcagagggc ggacagtata tggtgcagtc cgagcggtac ctccaacagc catccccgcc      900

tatccaggtg tggtttacca ggacggattt tacggtgctg acctctatat agaatctgca      960

aactgcttca gatcaaacag ggtggatatg cagcctacag atatgcacag cctgctactg     1020

caaccgcagc caccgctgct gcagccgctg cagccgctta cagtgacggt tatggcaggg     1080

tgtacacagc cgacccctac catgcccttg cccctgccgc tagctatgga gttggcgctg     1140

tggcgagttt ataccgaggt ggctacagcc gatttgcccc ctactgaagt gacgtgagac     1200

ccctgcaaat gggacagccc cccagttcat gaggcctggc tattgcaata tttactagta     1260

gaggaactct atagcaagat gaagaggaaa aacaaacaaa caaacaaaaa aaaacacaaa     1320

aaaagaaaga atactttttt atacctcact atgttctttg aatatgtatt tttcctttaa     1380

atttctgcct ttaattcttt tgttccaaa                                       1409


<210> 1462
<211> 787
<212> DNA
<213> Homo sapiens

<400> 1462
gttgcctgat gacgagagtt gggagtgtgg ctggggctgc ggatctccag cagtggcgtt       60

acttctagcg gctggatacc gggttctccg cgagatcgcg agatcccgag atattctccc      120

cgcacggaag cgacgactgg cctggccaga ggactcgcgt gggagcgagg tgccggcccc      180

gacaggacgg tgagaaattg ttttacagcc tacccgtata ttacaagaaa tctcaagtca      240

aacactggaa aagatgtcag aagattcaga aaaggaagac tattcagaca gaacaatcag      300

tgatgaagat gaatcggatg aggatatgtt catgaaattt gtaagtgaag atcttcatcg      360

gtgtgcactt ttaacagctg actcttttgg tgatcccttc ttcccccgga ctacacagat      420

actattagaa tatcagctag ggagatgggt gccacgtctt cgtgaaccaa gggatttata      480

tggtgtctct tcttctggtc cattgagccc aacacggtgg ccataccatt gtgaagtcat      540

cgatgaaaaa gtccagcata ttgatggagt ctcatgctgg agtgagtctc accaggctgg      600

agcgcagtgg tgcgatctcg gctcactgca acctccacct cccaggttca agcgattcgc      660

ctgcttcagc ctcctgagta gcagagacta caggcgcgtg ccaccacgct cagctaattt      720

tgtattttta gtagagacgg ggtttcacca tgttggccag gatggtctcc gtctcttgac      780

ctcgtga                                                                787


<210> 1463
<211> 2843
<212> DNA
<213> Homo sapiens

<400> 1463
gaggaagtga tcgctcccgg aggagcgcga gccgagcggc cggcgcagcg tgagacagca       60

catcctgccc gcgccggccc cgccaccttc gggagccgcc tgcaccaacg ctgccgccgc      120

ccaggagccg ccgccggctc ggggagccca gttccgccgc tgccgagcgc gtccaggaaa      180

ccaacatgtc tgacaaaagt gacttaaaag ctgagctaga gcgcaaaaag cagcgcttag      240

cacagataag agaagagaag aaacggaagg aagaggagag gaaaaagaaa gaggctgata      300

tgcagcagaa gaaagaaccc gttcaggacg actctgatct ggatcgcaaa cgacgagaga      360

cagaggcttt gctgcaaagc attggtatct caccggagcc gcctctagtc ccaaccccta      420

tgtctccctc ctcgaaatca gtgagcactc ccagtgaagc tggaagccaa gactcaggcg      480

atctggggcc attaacaaga agaagactgc ataaactggg cgtgtcaaag gtcacccaag      540

tggatttcct gccaagggaa gtagtgtcct actcaaagga gacccagact cctcttgcca      600

cgcatcagtc tgaagaggat gaggaagatg aggaaatggt ggaatctaaa gttggccagg      660

actcagaact ggaaaatcag gacaaaaaac aggaagtgaa ggaagcccct ccaagagagt      720

tgacagagga agaaaaacag cagatccttc attcagagga atttctcatc ttttttgacc      780

ggacaatacg ggtaattgaa agagccctgg ctgaagattc cgacatcttt tttgactaca      840

gcggccgaga gttagaggaa aaagatgggg atgttcaggc tggagccaat ctttctttca      900

atcgtcagtt ctatgatgaa cattggtcca agcatcgagt ggtcacttgt atggactggt      960

ccctccagta ccctgagctg atggtggctt cttacaacaa caatgaagat gctccccatg     1020

aaccagatgg agtggccttg gtttggaaca tgaagtttaa gaaaaccaca ccagaatacg     1080

tcttccactg tcagtcctct gtgatgtcgg tctgcttcgc ccgtttccat cctaacttgg     1140

tggttggtgg gacttactcg ggccagattg tcctctggga caatcgcagt catcgaagga     1200

ctccagtgca gcggacaccc ttatcagctg ctgcacacac gcatcccgtg tactgtgtaa     1260

atgttgttgg gacccagaat gctcataacc tcatcactgt ctccactgat ggcaaaatgt     1320

gttcctggag cctggacatg ctctcaactc cacaggagag catggagctg gtgtacaata     1380

agtccaagcc tgtcgctgtt accggaatgg ctttcccaac gggagacgtc aataacttcg     1440

tggttggcag tgaggaaggt acagtctaca cggcttgtcg tcatggaagc aaagcaggta     1500

ttggtgaggt ctttgaaggt caccaagggc cagtgacagg aattaactgc cacatggcag     1560

tgggcccaat cgacttttct cacctgtttg tcacatcatc atttgactgg actgtcaaac     1620

tgtggaccac caagcacaac aagccgctct actcctttga agacaatgca gactatgtgt     1680

acgatgtcat gtggtccccc gtgcatcctg cgctttttgc ctgcgtggac gggatggggc     1740

gcttggacct ctggaacctc aacaatgaca ccgaggttcc aacagcaagt gtggccattg     1800

agggggcatc cgccctaaac cgtgttcgtt gggcccaagc tggcaaagaa gttgctgttg     1860

gggactcgga aggccgtatt tgggtctatg acgttggaga gcttgcagtt ccccacaatg     1920

atgaatggac ccgatttgcc aggacccttg tggaaattcg tgctaacaga gctgatagcg     1980

aggaggaagg cactgttgag ttatctgcct agtggaaatg agccaccccc actgcagccc     2040

ccacctttgt gtcctagagc tcagcgtctg cagtcaagtc tcttgtattc ggtgtccatt     2100

cagtatcagt attgctgtga tattttgggt gccatattgt gccagctttg ctccaagtat     2160

tctaaatgtg tcccatcatg ctttccactg acccaaaatt caccacagca tttctatctt     2220

tatatttctg tctcaaaaat gaagagaagg gggttatggg ttaagttgct gccttttaac     2280

tactttgtag ctgtatttaa tagctggaaa cctctggtta aatttgtgct tacatgcact     2340

cctggcatag tcctattaaa tccatatgaa gccagatatg attgggtgca gatgtggtgt     2400

tcctcatatt atggtacagg gccaaagact tgagacgtgg tgttttacat ggtgactcac     2460

attatgaatg gatttactag aagaacattg ctgctcctta tttattgtag tgtgctgcat     2520

ggaacgtatt tatttgaaag cattaaaata aatgatccta gagcatgtgc ataatgagag     2580

gactgtattc tctctgctgc tgttgaggtt atattaagtt ccacatagca attacagtat     2640

gccagttcca ctgaagacat gaaatcttta gaggtttctt gcagtgaacg aaatgaattt     2700

taatgcctat tatttctggg tactttaaca atatttcaaa tatcattgac cactaatact     2760

tctcactgaa gctaacacag tctgacaaaa gtctatggtt cctaaatatg acatcagtgt     2820

tgccaataaa atgtttcaaa cca                                             2843


<210> 1464
<211> 687
<212> DNA
<213> Homo sapiens

<400> 1464
gacatcccag cgctgtgccc ggtcttgccc tctgtagccc ggctcgcccc gcgcttggac       60

atggaagggg ccgccgcgcc tgtggcgggg gaccgccccg acttggggct gggggcgccg      120

ggctctcccc gagaggcggt ggcgggggcg actgcagccc tggagcccag gaagccgcac      180

ggggtgaagc ggcatcacca caagcacaac ttgaagcacc gctacgagct gcaggagacc      240

ctgggcaaag gcacctacgg caaagtcaag cgggccaccg agaggttttc tggccgagtg      300

gttgctataa aatccattcg taaggacaaa attaaggatg aacaagacat ggttcacatc      360

agacgagaga ttgagatcat gtcatctctc aaccatcctc atatcatcag tatttatgaa      420

gtgtttgaga acaaagataa gattgtgatc atcatggaat atgccagcaa aggggagctg      480

tacgattaca tcagtgagcg gcgacgcctc agtgagaggg agacccggca cttcttccgg      540

cagatcgtct ctgctgtgca ctattgtcac aagaacggtg tggtccaccg ggacttgaag      600

ctgaaaagac ccagcagaga gaatcaggtt actactcttc cccagagcgc agtgagtctt      660

cggagctgtt ggacagtaat gatgtga                                          687


<210> 1465
<211> 1451
<212> DNA
<213> Homo sapiens

<400> 1465
ggaggcgtcg gggctgcgcc gtacaacttc cggctgtaaa gatggcggct tcctagtgag       60

tcggcggctg atttagaagg aggttcaggc tacggtgagc cgaaggggag gattctggct      120

tcccctgtcc gtgttccatc tagccacaca ggagccatgg aagtggcaga gcccagcagc      180

cccactgaag aggaggagga ggaagaggag cactcggcag agcctcggcc ccgcactcgc      240

tccaatcctg aaggggctga ggaccgggca gtaggggcac aggccagcgt gggcagccgc      300

agcgagggtg agggtgaggc cgccagtgct gatgatggga gcctcaacac ttcaggagcc      360

ggccctaagt cctggcaggt gcccccgcca gcccctgagg tccaaattcg gacaccaagg      420

gtcaactgtc cagagaaagt gattatctgc ctggacctgt cagaggaaat gtcactgcca      480

aagctggagt cgttcaacgg ctccaaaacc aacgccctca atgtctccca gaagatgatt      540

gagatgttcg tgcggacaaa acacaagatc gacaaaagcc acgagtttgc actggtggtg      600

gtgaacgatg acacggcctg gctgtctggc ctgacctccg acccccgcga gctctgtagc      660

tgcctctatg atctggagac ggcctcctgt tccaccttca atctggaagg acttttcagc      720

ctcatccagc agaaaactga gcttccggtc acagagaacg tgcagacgat tcccccgcca      780

tatgtggtcc gcaccatcct tgtctacagc cgtccacctt gccagcccca gttctccttg      840

acggagccca tgaagaaaat gttccagtgc ccatatttct tctttgacgt tgtttacatc      900

cacaatggca ctgaggagaa ggaggaggag atgagttgga aggatatgtt tgccttcatg      960

ggcagcctgg ataccaaggg taccagctac aagtatgagg tggcactggc tgggccagcc     1020

ctggagttgc acaactgcat ggcgaaactg ttggcccacc ccctgcagcg gccttgccag     1080

agccatgctt cctacagcct gctggaggag gaggatgaag ccattgaggt tgaggccact     1140

gtctgaacca tccctgtaca tctgcacctt cttgtgcaag gaagtccttg gcctaaagcc     1200

ttggttctca aactgggttc cttgggacct ccggggtggg ggggttccag gaggcacgta     1260

gggtaccttg cagggtccta ggagggaaac ccaggattcc aggagggatc ccaggaactg     1320

tgggcaccca ttttctgtgt ctcccagccc atttccactc ctagtttgtc atggataatt     1380

tttgttcttc cctgtgtgat ttttgccatc aaaataaaaa tttgagactc gttaaccgaa     1440

gtccacgcca a                                                          1451


<210> 1466
<211> 913
<212> DNA
<213> Homo sapiens

<400> 1466
ccacctcctg ccctgctggg gtccagccat gtcccagcct gcgggaggca ggaggaagcc       60

caggacccta gggccgcctg tgtgcagtat ccggcctttc aagtcgagtg agcagtacct      120

ggaggccatg aaggaagacc tggctgagtg gcttcgcgac ctctatgggc tggacatcga      180

cgcagccaac ttcctgcagg tgctggaaac gggcctggtg ctgtgccaac acgccaacgt      240

tgtcactgac gctgccctgg ccttcctggc tgaggcacct gcccaagccc agaagattcc      300

catgccccgg gtcggggtct cctgcaatgg ggccgcccag ccaggtacct tccaggccag      360

ggacaatgtc tctaacttca tccagtggtg tcgaaaggag atgggcatcc aagaggtgct      420

gatgttcgag acggaggact tggtgctgcg caagaacgtg aagaacgtgg tgctgtgttt      480

gctggagctg ggccgccggg cgtggcgctt tggtgttgcg gcgcccacac tcgtgcagct      540

ggaggaggag atcgaggagg aggtgcggcg ggagctggcc ctgcccccac ttccgcaacc      600

tggaccagat ggtgcagagc cttgtgagcc actgcacgtg cccagtgcag ttctccatgg      660

tcaaagtgtc tatgtcttcc tgggtccagc caggcagccc cccaaggaca ggctgttgag      720

agctgtgctg ggcagcaagg gaggggaggc atcccgggtg gatggagctt cagtaggtga      780

ggaggaggag gaaggaaagg aggagaaaga gccagccgct ccattggaga gcagccccca      840

acctccagag ggcctgcaac ctcactggct taatcaagct ccacttccac ctgaggagga      900

gtcctgggtc tga                                                         913


<210> 1467
<211> 4348
<212> DNA
<213> Homo sapiens

<400> 1467
cgccgggaag cgaccggctg ctgggcttaa ggcgggagtg accgcttaac cagtgaggga       60

agcactgaag agcgccagtc gacgtgggtg cgacaactcg cggagtctta ggagcaaaac      120

gtctggggcc tgcgagccag gacccttctg aagccttagg tgtctatcgg cgacgtgtac      180

ggtcactgca gctccggagc gcggaaccct cagccaggag gcgcggctgg tcggtcccag      240

gtcccggcct ccgtaatgag agcccggaac cactctttgt gccgcagctt cgcagattcc      300

tataggcaat ggaaactgat ctcaattccc aggacagaaa ggacctggac aagtttatta      360

aattttttgc cctcaagact gtccaagtga ttgtccaggc tcggcttggt gaaaagattt      420

gcactcgttc atcatcttct ccaacgggtt cagattggtt caacttagca atcaaagaca      480

tcccagaggt tacacatgaa gcaaagaagg cactggcagg acagctgcct gcagtcggga      540

ggtccatgtg tgtggagatt tcacttaaga cttctgaggg agattccatg gagctggaaa      600

tatggtgtct tgaaatgaat gaaaagtgtg ataaagaaat caaagtttcc tacacggtgt      660

acaacagact gtcattgctg ctgaagtccc ttcttgctat aactagggtg acaccagcct      720

ataggctctc caggaaacaa gggcatgaat atgtcatatt atacaggata tattttggag      780

aagttcagct gagtggctta ggagaaggct tccagacagt tcgtgttggg acagtgggca      840

cccctgtggg caccatcact ctttcttgtg cttacagaat taacttggca ttcatgtcta      900

ccaggcaatt tgagaggacc ccacctatca tggggattat tattgatcac tttgtggacc      960

gtccctatcc cagctcctct cccatgcacc cctgcaatta cagaactgct ggtgaggaca     1020

ctggagtaat atacccgtct gtagaagact ctcaagaagt gtgtaccacc tctttttcca     1080

cctccccacc atcccagctc tcaagctctc gcctttccta tcagcctgct gccctgggcg     1140

ttggatcagc tgacctggct tatccagtag tgtttgctgc tggcttaaat gctacacacc     1200

ctcaccagct gatggttcct gggaaggaag gtggggtacc ccttgctccc aaccagcctg     1260

tccatggtac ccaggctgac caggagagac tggcaacctg caccccttct gacagaaccc     1320

actgtgctgc cacaccctcc agtagtgagg atactgaaac cgtatcaaac agcagtgagg     1380

gacgggcctc ccctcacgat gtcttggaga ccatctttgt ccgaaaagtg ggggcttttg     1440

tcaacaaacc cattaaccag gtgaccctga cgagtttgga tatacccttt gccatgtttg     1500

ctcccaagaa tttggagctg gaggataccg atccaatggt gaatcctcca gattccccag     1560

agactgaatc tcctctccag ggcagcctgc actcagatgg ctccagcggg ggcagcagtg     1620

gcaataccca tgatgacttt gttatgatag actttaaacc agctttttct aaagatgaca     1680

ttcttccgat ggacctgggg accttctatc gggagtttca gaacccacct cagctgagca     1740

gcctctccat agatattgga gcacagtcca tggctgaaga cttggactca ttaccagaga     1800

agctggctgt gcatgagaag aatgtccgcg agtttgatgc ctttgtggaa accctgcagt     1860

aaaagtatcc ttgagtccca gcagcacccc ctttttgtgg ccccagggca taagcagcct     1920

cccatgcatc agctgctccc acccctcatc ctgctctgag ccaggtggaa gggaggctgg     1980

cttctcccat ggggacccag aagtccctac tcttggacct cctggagact ccgtggcggc     2040

agtcaagccc agtgcccagt tggagaagac tcacgtgctg gccttggaga tgggaagaac     2100

cttcgtacga aaaagccctc agcagggcca tctgtgtgcc ctgcccatca ccaactgctt     2160

cccaagggtg tcatcctgtt cctcctgctg ccggcctcct gcctgggcct gccttgcagc     2220

tggccccttc cctgcctgct gtcaccatcc actgtttgac attccagctg gtggccaaga     2280

gattggtgtg gagtcgcaga aagaggaagg agacagtgcc aggaggaaga aggaaggagt     2340

cccttagctc tcttcattgt cccctttact tcctgctatc ttcttctcct cttcttctct     2400

ctcttgcctc tatgcctgta tttctggcaa tatgacaggc ctgcctaccc aagatcagaa     2460

ctccaaaacc actcccaccc ctgaaggtcg ggagggtctg agcagccctg gtggctgcct     2520

gtgctcaggt cctcagctcc atgggaaata aaaatggcac cctgaatctc taggattttg     2580

tcacttggag tcacagcaaa gttctcttcc tcttgtcccc ccgttgctgc tccttggtta     2640

tagaacatgg taaatattta ttactttcag agaaaccaga tattttatag aggaaatatg     2700

tttgaggtga gttgtttttc acttggagaa ggcggagggc tcttcctggg acggagacct     2760

cctcctccgg aggttattga gaatccgggc tgctgctttg aggatcttcc caccatacag     2820

acagcgagat ccaagaagag ggctggccgg gggcaaagtc acctcccagt gtggctgcac     2880

tggaactgac taaaggcttt accttggata gttgcgtatt cctggtgaga gccttacatc     2940

tcccacagtt tctgcagagt gactgactcc attctggcag cccaggaagt cctgggtgct     3000

aaatgtgatg gccacatgta gtggttaggg gatgttgtgt gtgtccccca actgcctggg     3060

tacttgttcc tgatccctgg ggctgtcctg tggagctttt cctcctgctt gggcctagct     3120

accatctccc tctaatccca ggttctctac actgccctgg ggtttaccag ctggattggc     3180

ttctggttga gaaatcaaag ctgggcgtat gattgactta acccttcagg tattgttact     3240

tgaataagtc aagtgcctag cctcacccac ctatgatctg tcctttccca gcctcgctgg     3300

tagtcctggt caaggagatc taggtctact ccattcctcc tggcccacct ggggcattca     3360

ctggcagcag ctgtgcttca gtggagcagg tggttctcag ctgcttgtta gtatactgca     3420

tgtgacactg ttcccacata caaggctgac ttctgaggat tggagcaggc tctggcgggg     3480

accagagctc tgcgtgctgc tgctgccacc aagaagtgtt agcagaagca gtagcagcca     3540

actggccctc ctgactttgg cccagagcac atgcgtggct tgctgaaccc aggctcaggt     3600

ttatccccaa ggccccagct ttgagaaggg ggaaggcccc tggtaagtta ttgatgcccc     3660

catatttcag ctactgctct ctttccaagg ccttgcatgg aaaggcctag ccattgtctg     3720

aggcagcaat ctttggcatc tacaggtggc agcagccttt caccagggct ccatctgtga     3780

agagtctcag ccatgacttt gagctgagct tgggagaagt aaagcaactg ttaaggccag     3840

cccttgcccc tcagacctgc catgaaagga atgagcccta gactgactcc tgcagcaccc     3900

ccgggacagg ctgggaccag ctgtttgtct ccaggtgtca gagtccctcc tcctcctcca     3960

acctctccaa cctactttgt ttggaaatac cgagctacac ttcaaaatgt attcaaggga     4020

tttccaataa atttttttct gtactttaca gcctcctgtc ctgtaggttg tctgaagacc     4080

tcgtaacccc ttccccaccc ctgccccagt gcaggtctgg gaaaggggag agtggtgcgt     4140

tgtgaagcgc agaaagacct caagtgtctg ggcaagcctg ttttgagtcg ggtgtggcct     4200

cttaggggct gtataccctg gggtttcctg ggtcaggaaa cttcttagta tttctctttc     4260

cctggtcccc tatcaggggc ttgaatttga atattcagtt ggagaatgca tttaaaatac     4320

acccatagta aaatctccat aaaatgca                                        4348


<210> 1468
<211> 1590
<212> DNA
<213> Homo sapiens

<400> 1468
acagtagctc acacctgtaa tcccagcact ttggaaggcc gaggtgggcg gatcacctga       60

gctcaggagt ttgagaccag cctgtctcta ctaacaatat aaaaattagc tgggagtcac      120

ggtgggcgcc tgtaatccca gctactcggg aggctgaggc aggagaattg cttgaaccca      180

ggagacagag gttgtagtga gctgagatcg caccactgca ctctagcctt ggcaacagtg      240

caagactgtc tcaaaaacag caacagagag caggacgtga gacttctacc tgctcactca      300

gaatcatttc tgcaccaacc atggccacgt ttgtggagct cagtaccaaa gccaagatgc      360

ccattgtggg cctgggcact tggaagtctc ctcttggcaa agtgaaagaa gcagtgaagg      420

tggccattga tgcaggatat cggcacattg actgtgccta tgtctatcag aatgaacatg      480

aagtggggga agccatccaa gagaagatcc aagagaaggc tgtgaagcgg gaggacctgt      540

tcatcgtcag caagttgtgg cccactttct ttgagagacc ccttgtgagg aaagcctttg      600

agaagaccct caaggacctg aagctgagct atctggacgt ctatcttatt cactggccac      660

agggattcaa gtctggggat gaccttttcc ccaaagatga taaaggtaat gccatcggtg      720

gaaaagcaac gttcttggat gcctgggagg ccatggagga gctggtggat gaggggctgg      780

tgaaagccct tggggtctcc aatttcagcc acttccagat cgagaagctc ttgaacaaac      840

ctggactgaa atataaacca gtgactaacc aggttgagtg tcacccatac ctcacacagg      900

agaaactgat ccagtactgc cactccaagg gcatcaccgt tacggcctac agccccctgg      960

gctctccgga tagaccttgg gccaagccag aagacccttc cctgctggag gatcccaaga     1020

ttaaggagat tgctgcaaag cacaaaaaaa ccgcagccca ggttctgatc cgtttccata     1080

tccagaggaa tgtgattgtc atccccaagt ctgtgacacc agcacgcatt gttgagaaca     1140

ttcaggtctt tgactttaaa ttgagtgatg aggagatggc aaccatactc agcttcaaca     1200

gaaactggag ggcctgtaac gtgttgcaat cctctcattt ggaagactat cccttcaatg     1260

cagaatattg aggttgaatc tcctggtgag attatacagg agattctctt tcttcgctga     1320

agtgtgacta cctccactca tgtcccattt tagccaagct tatttaagat cacagtgaac     1380

ttagtcctgt tatagacgag aatcgaggtg ctgttttaga catttatttc tgtatgttca     1440

actaggatca gaatatcaca gaaaagcatg gcttgaataa ggaaatgaca attttttcca     1500

cttatctgat cagaacaaat gtttattaag catcagaaac tctgccaaca ctgaggatgt     1560

aaagatcaat aaaaaaaata ataatcataa                                      1590


<210> 1469
<211> 9411
<212> DNA
<213> Homo sapiens

<400> 1469
gagcccaagg tggtgtttgc caaggagcag ccagtgcaca gggaggtgca ggcccaggcg       60

ggggccagca ccacactcag ctgcgaggtg gctcaggccc agacggaggt gatgtggtac      120

aaggacggga agaagctgag cttcagctcg aaagtgcgca tggaggctgt gggctgcaca      180

cggaggctgg tggtgcagca ggcgggccag gcggtcgccg gggagtacag ctgcgaggcg      240

gggagccagc ggctctcctt ccacctgcac gtggcagagc ccaaggcggt gtttgctaag      300

gagcagccag cacacaggga ggtgcaggct gaagcagggg ctagcgccac actgagctgt      360

gaggtggccc aggcccagac agaggtgact tggtacaagg acgggaagaa gctgagctcc      420

agcttgaaag tgcatgtgga ggctgcaggc tgtacacgga ggctggtggt gcagcaggca      480

ggccaggcag acaccggaga gtatagctgt gaggctgggg gccagcagct ctccttccgc      540

ctgcaagtgg cagagcccaa ggcggtgttt gccaaggagc agccagcgag cagggaggtg      600

caggctgagg cggggaccag tgccacgctg agctgcgagg tggcccaggc ccagacagag      660

gtgacgtggt acaaggacgg gaagaaactg agctccagct cgaaagtgcg aatggaggcc      720

gtgggctgca cacggaggct ggtggtgcag gaggcaggcc aggcggacgc cggggagtac      780

agctgcaagg ccggggatca gcggctgtcc ttccacctgc acgtggcaga gcccaaggtg      840

gtgtttgcca aggagcagcc agcacacagg gaggtgcagg ctgaggcggg ggccagtgcc      900

acgctgagct gcgaggtggc ccaggcccag acagaggtga cgtggtacaa ggatgggaag      960

aagctgagtt ccagctcgaa agtgcgcgtg gaggccgtgg gctgcacacg gaggctggtg     1020

gtgcagcagg cgggccaggc agaggccggg gagtacagct gcgaggcagg gggtcagcag     1080

ctctccttcc gcctgcaggt ggcagagccc aaggcggtgt ttgccaagga gcaggtggtg     1140

tttgccaagg atcagccggt gcacagggag gtgcaggctg aggcagggac cagcaccatg     1200

ctgagctgcg aggtggccca agcccagacg gaggttatgt ggtacaagga cgggaagaag     1260

ctgagctcca gctcgaaaat gcgtgtggag gccgtgggct gcacacggag gctggtggtg     1320

caggaggcag gccaggcgga cgccggggag tacagctgcg aggctggggg ccagcggctc     1380

tccttccatc tgcatgtggc tgagcccaag gtggtgtttg ccaaggagca gccggcatgc     1440

agggaggtgc aggcggaggc gggggccagt gccacgctga gctgtgaggt ggcccagggc     1500

cagatggagg tgacatggta caaggacggg aagaagctga gctccagctc aaaagtgcac     1560

atggaggcca gcggctacac acggaggctg gtagtgcagc aggcgggcca ggcggatgct     1620

ggggagtaca gctgtgaggc ggggggccaa cggctgtcct tccgcctgca cgtggcagag     1680

ctggagcccc aaatttcaga gagaccctgc cgcagggagc ctctggtggt caaggagcat     1740

gaagacatca tcctgaccgc cacactggcc acaccctctg cggccacggt gacctggctc     1800

aaggatggtg tggagattcg ccgcagcaag cggcatgaga cagccagcca gggggacacc     1860

cacaccctga ccgtgcatgg cgcccaggtt ctggacagcg ccatctacag ctgccgtgtg     1920

ggcgcagagg ggcaggactt cccagtgcag gtggaagagg tggccgccaa gttctgccgg     1980

ctgctggagc ctgtgtgcgg cgagctgggt ggcacggtga cactggcctg cgagctaagc     2040

ccagcgtgtg cagaggtggt gtggcgctgc ggcaacacgc agcttcgggt gggcaagcgc     2100

ttccagatgg tggccgaggg gcccgtgcgc tcactcactg tgttggggct gcgcgcagag     2160

gacgcagggg agtacgtgtg tgagagccgt gatgaccaca ccagtgcgca gctcaccgtc     2220

agtgtgcccc gagtggtgaa gtttatgtct gggctgagca ccgtggtcgc agaggagggc     2280

ggcgaggcca ccttccagtg cgtggtgtcc cccagtgatg tggcagtcgt gtggttccgg     2340

gacggtgccc tgcttcagcc cagcgagaag tttgccatat cacagagtgg cgccagccac     2400

agcctgacca tctcagacct ggtgctggag gacgcgggcc agatcaccgt ggaggctgag     2460

ggcgcctcat cctctgctgc cctgagggtc cgagaggcgc ctgtgctgtt caaaaagaag     2520

ctggagccgc agacggtgga ggagcggagc tcggtgaccc tggaggtgga gctgacgcgg     2580

ccgtggccgg agctgaggtg gacacggaac gcgacggccc tggcgccggg aaagaacgtg     2640

gagatccacg ccgagggcgc ccgccaccgc ctggttctgc acaacgtagg ttttgccgac     2700

cgtggcttct ttggctgcga gacgccggat gacaagacac aggccaaact caccgtggag     2760

atgcgccagg tacggctcgt acggggcctg caggcagtgg aggcacggga gcagggcacg     2820

gctaccatgg aggtgcagct gtcgcatgcg gacgtggatg gcagctggac tcgtgacggt     2880

ctgcggttcc agcaggggcc cacgtgccac ctggctgtgc ggggccccat gcacaccctc     2940

acactctcgg ggctgcggcc agaggatagt ggccttatgg tcttcaaggc cgaaggagtg     3000

cacacgtcgg cgcggctcgt ggtcaccgag cttcccgtga gcttcagccg cccgctgcag     3060

gacgtggtga ccactgagaa ggagaaggtt accctggagt gcgagctgtc gcgtcctaat     3120

gtggatgtgc gctggctgaa ggacggtgtg gagctgcggg caggcaagac gatggccatc     3180

gcagcccagg gcgcctgcag gagcctcacc atttaccggt gcgagttcgc ggatcaggga     3240

gtgtatgtgt gtgatgccca tgatgcccag agctctgcct ccgtgaaggt acaaggaagg     3300

acatacactc tcatctaccg gagagtcctg gcggaagatg caggagagat ccaatttgta     3360

gccgaaaatg cagaatcgcg agcccagctc cgagtgaagg agctgccagt gaccctcgtg     3420

cgcccgctgc gggacaagat tgccatggag aagcaccgcg gtgtgctgga gtgtcaggtg     3480

tcccgggcca gcgcccaggt gcggtggttc aagggcagtc aggagctgca gcccgggccc     3540

aagtacgagc tggtcagtga tggcctctac cgcaagctga tcatcagtga tgtccacgca     3600

gaggacgagg acacctacac ctgtgacgcc ggtgatgtca agaccagtgc acagttcttc     3660

gtggaagagc aatccatcac cattgtgcgg ggtctgcagg acgtgacagt gatggagccc     3720

gctcctgcct ggtttgagtg tgagacctcc atcccctcag tgcggccacc taagtggctc     3780

ctggggaaga cggtgttgca ggctgggggg aacgtgggcc tggagcagga gggcacggtg     3840

caccggctga tgctgcggcg gacctgctcc accatgaccg ggcccgtgca cttcaccgtt     3900

ggcaagtcgc gctcctctgc ccgcctggtg gtctcagaca tccccgtagt cctcacacgg     3960

ccgttggagc ccaagacagg gcgtgagctg cagtcagtgg tcctgtcctg cgacttccgg     4020

ccagccccca aggctgtgca gtggtacaag gatgacacgc ccctgtctcc ctctgagaag     4080

tttaagatga gcctggaggg tcagatggct gagctgcgca tcctccggct catgcctgct     4140

gatgctggtg tctaccggtg ccaggcgggc agtgcccaca gcagcactga ggtcactgtg     4200

gaagcgcggg aggtgacagt gacagggccg ctacaggatg cagaggccac ggaggagggc     4260

tgggccagct tctcctgtga gctgtcccac gaggatgagg aggtcgagtg gtcgctcaac     4320

gggatgcccc tgtacaacga cagcttccat gagatctcac acaagggccg gcgccacacg     4380

ctggtactga agagcatcca gcgggctgat gcgggcatag tacgcgcctc ctccctgaag     4440

gtgtcgacct ctgcccgcct ggaggtccga gtgaagccgg tggtgttcct gaaggcgctg     4500

gatgacctgt ccgcagagga gcgcggcacc ctggccctgc agtgtgaagt ctctgacccc     4560

gaggcccatg tggtgtggcg caaagatggc gtgcagctgg gccccagtga caagtatgac     4620

ttcctgcaca cggcgggcac gcgggggctc gtggtgcatg acgtgagccc tgaagacgcc     4680

ggcctgtaca cctgccacgt gggctccgag gagacccggg cccgggtccg cgtgcacgat     4740

ctgcacgtgg gcatcaccaa gaggctgaag acaatggagg tgctggaagg ggaaagctgc     4800

agctttgagt gcgtcctgtc ccacgagagt gccagcgacc cggccatgtg gacagtcggt     4860

gggaagacag tgggcagctc cagccgcttc caggccacac gtcagggccg aaaatacatc     4920

ctggtggtcc gggaggctgc accaagtgat gccggggagg tggtcttctc tgtgcggggc     4980

ctcacctcca aggcctcact cattgtcaga gagaggccgg ccgccatcat caagcccctg     5040

gaagaccagt gggtggcgcc aggggaggac gtggagctgc gctgtgagct gtcacgggcg     5100

ggaacgcccg tgcactggct gaaggacagg aaggccatcc gcaagagcca gaagtatgat     5160

gtggtctgcg agggcacgat ggccatgctg gtcatccgcg gggcctcgct caaggacgcg     5220

ggcgagtaca cgtgtgaggt ggaggcttcc aagagcacag ccagcctcca tgtggaagaa     5280

aaagcaaact gcttcacaga ggagctgacc aatctgcagg tggaggagaa aggcacagct     5340

gtgttcacgt gcaagacgga gcaccccgcg gccacagtga cctggcgcaa gggcctcttg     5400

gagctacggg cctcagggaa gcaccagccc agccaggagg gcctgaccct gcggctcacc     5460

atcagtgccc tggagaaggc agacagcgac acctatacct gcgacattgg ccaggcccag     5520

tcccgggccc agctcctagt gcaaggccgg agagtgcaca tcatcgagga cctggaggat     5580

gtggatgtgc aggagggctc ctcggccacc ttccgttgcc ggatctcccc ggccaactac     5640

gagcctgtgc actggttcct ggacaagaca cccctgcatg ccaacgagct caatgagatc     5700

gatgcccagc ccgggggcta ccacgtgctg accctgcggc agctggcgct caaggactcg     5760

ggcaccatct actttgaggc gggtgaccag cgggcctcgg ccgccctgcg ggtcactgag     5820

aagccaagcg tcttctcccg ggagctcaca gatgccacca tcacagaggg tgaggacttg     5880

accctggtgt gcgagaccag cacctgcgac attcctgtgt gctggaccaa ggatgggaag     5940

accctgcggg ggtctgcccg gtgccagctg agccatgagg gccaccgggc ccagctgctc     6000

atcactgggg ccaccctgca ggacagtgga cgctacaagt gtgaggctgg gggcgcctgc     6060

agcagctcca ttgtcagggt gcatgcgcgg ccagtgcggt tccaggaggc cctgaaggac     6120

ctggaggtgc tggagggtgg tgctgccaca ctgcgctgtg tgctgtcatc tgtggctgcg     6180

cccgtgaagt ggtgctatgg aaacaacgtc ctgaggccag gtgacaaata cagcctacgc     6240

caggagggtg ccatgctgga gctggtggtc cggaacctcc ggccgcagga cagcgggcgg     6300

tactcatgct ccttcgggga ccagactact tctgccaccc tcacagtgac tgccctgcct     6360

gcccagttca tcgggaaact gagaaacaag gaggccacag aaggggccac ggccacgctg     6420

cggtgtgagc tgagcaaggc agcccctgtg gagtggagaa aggggtccga gaccctcaga     6480

gatggggaca gatactgtct gaggcaggac ggggccatgt gtgagctgca gatccgtggc     6540

ctggccatgg tggatgccgc ggagtactcg tgtgtgtgtg gagaggagag gacctcagcc     6600

tcactcacca tcaggcccat gcctgcccac ttcataggaa gactgagaca ccaagagagc     6660

atagaagggg ccacagccac gctgcggtgt gagctgagca aggcggcccc cgtggagtgg     6720

aggaaggggc gtgagagcct cagagatggg gacagacata gcctgaggca ggacggggct     6780

gtgtgcgagc tgcagatctg tggcctggct gtggcagatg ctggggagta ctcctgtgtg     6840

tgtggggagg agaggacctc tgccactctc accgtgaagg ccctgccagc caagttcaca     6900

gagggtctga ggaatgaaga ggccgtggaa ggggccacag ccatgttgtg gtgtgaactg     6960

agcaaggtgg cccctgtgga gtggaggaag gggcccgaga acctcagaga tggggacaga     7020

tacatcctga ggcaggaggg gaccaggtgt gagctgcaga tctgtggcct ggccatggcg     7080

gacgccgggg agtacttgtg tgtgtgcggg caggagagga cctcagccac gctcaccatc     7140

agggctctgc ctgccaggtt catagaagat gtgaaaaacc aggaggccag agaaggggcc     7200

acagctgtgc tgcagtgtga gctgaacagt gcagcccctg tggagtggag aaaggggtct     7260

gagaccctta gagatgggga cagatacagc ctgaggcagg acgggactaa atgtgagctg     7320

cagattcgtg gcctggccat ggcagacact ggggagtact cgtgcgtgtg cgggcaggag     7380

aggacctcgg ctatgctcac cgtcagggct ctacccatca agttcacaga gggtctgagg     7440

aacgaagagg ccacagaagg ggcaacagcc gtgctgcggt gtgagctgag caagatggcc     7500

cccgtggagt ggtggaaggg gcatgagacc ctcagagatg gagacagaca cagcctgagg     7560

caggacgggg ccaggtgtga gctgcagatc cgcggcctcg tggcagagga cgctggggag     7620

tacctgtgca tgtgcgggaa ggagaggacc tcagccatgc tcaccgtcag ggccatgcct     7680

tccaagttca tagagggtct gaggaatgaa gaggccacag aaggggacac ggccacgctg     7740

tggtgtgagc tgagcaaggc ggcaccggtg gagtggagga aggggcatga gaccctcaga     7800

gatggggaca gacacagcct gaggcaggac gggtccaggt gtgagctgca gatccgtggc     7860

ctggctgtgg tggatgccgg ggagtactcg tgtgtgtgcg ggcaggagag gacctcagcc     7920

acactcactg tcagggccct gcctgccaga ttcatagaag atgtgaaaaa ccaggaggcc     7980

agagaagggg ccacggccgt gctgcaatgt gagctgagca aggcggcccc cgtggagtgg     8040

aggaaggggt ctgagaccct cagaggtggg gacagataca gcctgaggca ggatgggacc     8100

agatgtgagc tgcagattca tggcctgtct gtggcagaca ctggggagta ctcgtgtgtg     8160

tgcgggcagg agaggacctc ggccacactc accgtcaggg ccctgcctgc acgacactca     8220

agatctgaag accaaggagg cctcagaagg ggccacagct acactgcagt gtgagctgag     8280

caaggtggcc cctgtggaat ggaagaaggg tcctgagacc ctcagagatg ggggcagata     8340

cagcctgaag caggatggga cgaggtgtga gctgcagatc catgacctgt ctgtggcgga     8400

tgctggggaa tactcatgca tgtgtggaca agagaggacc tcggccacgc tcactgtcag     8460

ggccctgcct gccaggttca cagagggtct gaggaatgaa gaggccatgg aaggggccac     8520

agccacactg caatgtgagc tgagcaaggc agcccctgtg gagtggagga aaggccttga     8580

ggctctcaga gatggggaca aatacagcct gagacaagac ggggctgtgt gtgagctgca     8640

gattcatggc ctggctatgg cagataacgg ggtgtactca tgtgtgtgtg ggcaggagag     8700

gacctcagct acactcactg tcagggccct gcctgccaga ttcatagagg atatgagaaa     8760

ccagaaggcc acagaagggg ctacagtcac attgcaatgt aagctgagaa aggcggcccc     8820

cgtggagtgg agaaaggggc ccaacaccct caaagatggg gacaggtaca gcctgaagca     8880

ggatgggacc agttgtgagc tgcagattcg tggcctggtc atagcagatg ctggagaata     8940

ctcgtgcata tgtgagcagg agaggacctc ggccacgctc actgtcaggg ccctgccggc     9000

cagattcata gaagatgtga gaaatcacga ggccacagaa ggggccacag ctgtgctgca     9060

gtgtgagctg agcaaggcgg cccccgtgga gtggcggaag gggtctgaga ccctcagaga     9120

tggggacaga tatagcctga ggcaggacgg gacgaggtgt gagctgcaga ttcgtggcct     9180

ggctgtggag gacactggag agtatttgtg tgtgtgcggg caggagagaa cctcagctac     9240

actcactgtc agggccctgc cagccagatt catagacaac atgacaaacc aggaggccag     9300

agaaggggcc acggccacac tgcactgtga actgagcaag gtggcccctg tggagtggag     9360

gaagggacct gaaaccctcc gagatgggga cagacacagc ctgaggcagg a              9411


<210> 1470
<211> 4883
<212> DNA
<213> Homo sapiens

<400> 1470
taaagcccac gtcatgttct tcctttactg cagggcctct taatggggct taaaacctag       60

gatgggttaa gtaaacaatg taggtgagtt tagtgtgcaa acagctgaaa tcaccggctg      120

cattttaagc tcgtctacag cagcaacctg cagacaccta ttcagagaga ttactaaatt      180

ccctccttcc cattaataaa aaggaccaga atatcagtct acaaaagaca ctgcgttgct      240

gcgaaccagc tctcgcttgc gcgatcagga agaagggcgg caaggctgga gcctcgggac      300

cggagaaagg cagcctgctt gtgacgtcaa atcagcggac tcttatcttg gctttaggcc      360

ggttccggtt ccccggcttt ccgggcgcga gcgtgtgcga gcgcggcagc gtactgcgcg      420

tgctccgcag agggacacgg gaaggttggg tccggctctg gaggagatgc gtgattggct      480

gacgctgtgc tcgggggttc cctggccctt tcggcagggg taaaacaata agagggggcg      540

gtggcaaagg gggcgggacg tccgtggtcc ttgtcgcacg tcgcagcgcc tggcgcccgg      600

gaagaggtgg ttgtgaggca gacgaactcg cggctctccg gcttccgagg cttccgagtt      660

gtcggaggaa gggggcggcg agcaataaga acccgccgca cccggtcctc agcgactctt      720

ctgacctccg cgcgacgtac ccgccgccgc cgttggctgg agcatttgac attgtgcagc      780

aaagaaatgg ttatggagaa gcccagtccg ctgcttgtag ggcgggagtt tgtgaggcaa      840

tattatactt tgctgaataa agctccggaa tatttacaca ggttttatgg caggaattct      900

tcctatgttc atggtggagt agatgctagt ggaaagcccc aggaagctgt ttatggccaa      960

aatgatatac accacaaagt attatctctg aacttcagtg aatgtcatac taaaattcgt     1020

catgtggatg ctcatgcaac cttgagtgat ggagtagttg tccaggtcat gggtttgctg     1080

tctaacagtg gacaaccaga aagaaagttt atgcaaacct ttgttctggc tcctgaagga     1140

tctgttccaa ataaatttta tgttcacaat gatatgtttc gttatgaaga tgaagtgttt     1200

ggtgattctg agcctgaact tgatgaagaa tcagaagatg aagtagaaga ggaacaagaa     1260

gaaagacaac catctcctga acctgtgcaa gaaaatgcta acagtggtta ctatgaagct     1320

caccctgtga ctaatggcat agaggagcct ttggaagaat cctctcatga acctgaacct     1380

gagccagaat ctgaaacaaa gactgaagag ctgaaaccac aagtggagga gaagaactta     1440

gaagaactag aggagaaatc tactactcct cctccggcag aacctgtttc tctgccacaa     1500

gaaccaccaa aggctttctc ctgggcttca gtgaccagta aaaacctgcc tcctagtggt     1560

actgtttctt cctctggaat tccaccccat gttaaagcac cagtctcaca gccaagagtc     1620

gaagctaaac cagaagttca atctcagcca cctcgtgtgc gtgaacaacg acctagagaa     1680

cgacctggtt ttcctcctag aggaccaaga ccaggcagag gagatatgga acagaatgac     1740

tctgacaacc gtagaataat tcgctatcca gatagtcatc aactttttgt tggtaacttg     1800

ccacatgata ttgatgaaaa tgagctaaag gaattcttca tgagttttgg aaacgttgtg     1860

gaacttcgca tcaataccaa gggtgttggg ggaaagcttc caaattttgg ttttgtggtt     1920

tttgatgact ctgaaccagt tcagagaatc ttaattgcaa aaccgattat gtttcgaggg     1980

gaagtacgtt taaatgtgga agagaaaaaa acaagagctg caagagagcg agaaaccaga     2040

ggtggtggtg atgatcgcag ggatattagg cgcaatgatc gaggtcccgg tggtccacgt     2100

ggaattgtgg gtggtggaat gatgcgtgat cgtgatggaa gaggacctcc tccaaggggt     2160

ggcatggcac agaaacttgg ctctggaaga ggaaccgggc aaatggaggg ccgcttcaca     2220

ggacagcgtc gctgaagctc cactgttggc aaagtcttgg cagtggtaca ttattcatcg     2280

tgtttgcatt cttgttaatt ttttttttgg ctttggaatg tgacacagcc tttttgatca     2340

tttctttgat gtgaaaagca tctttggtta tcagttaaat tgaggtggac attatttccc     2400

caatttcaca acaggattca cattgttaat ttataaatct agacttggag aattaaggac     2460

tgagaaatga ccatatctta aactatctac gacaaagtga acttaaaagg acatgcccac     2520

tgaattcagg tcctttgagt aaaaaaaaaa tcttctgctg cacattttgt ttaagtgtta     2580

ctgtttctgc ctgttaatgc tgggaacaca aatagtgcaa tttgtgcaat tggagaatct     2640

tgcctttttt cttggctccc cccaaaaata caaaccaaca gaaacttgtt atgcactcat     2700

caaaatgtac taatgggtac tctgaactca ttaacattga catctgcaac aggaggcaac     2760

agggaaaaaa tctcatcttc ttttccagta gaaaatagtt tgtgaaatga tgagggcatt     2820

ttatctgctt gctgtgacca gcgtgtgtac acataaacct taacaagact acaagtatat     2880

tccagaagga aatcatttta gttatgaact aaataataaa aattagaact tcaaatgcga     2940

tggtcttgac tattagacca gatttagtag ctccatatct aagatttttc tacctgcccc     3000

tcttcagtac agggatggct ggctgctcaa cacactcctc ctcccctttt ttcctttctt     3060

taagctgtgt acagtgaaaa ttgtctttac tgtatttttg ttctctggta atgtaataag     3120

catgatggtg ccttctatta atacatcatt ccagtcttgc tggtaatttt gtacagtata     3180

gtgtatgaat tgctgtgctg caaagccaaa cagctgcaaa atgttgaaaa atcatcgaaa     3240

tgtataaaaa ttgcagtatc tttaaaatca gtaaaatgga ctagcatatt atttatcttg     3300

ttcttcagtt aacaactttg tgttctctgt gggagggagg gagtcctgtg tgtttgtggg     3360

gagagggaag gaggaagtca gttatttgag taagcctcta gttgactttt ctcttagcct     3420

gaatgtggac gttgaaacat atcacttcag ggcttggaaa agtcagtcaa cttgacgtac     3480

atttttagtg acattttaaa agcagtcaga ttctataaat ggcaagtaag cctgaagtga     3540

ggatactgca attttcggag aaaagaacag cagctcttta agtgtttgca ttttctattt     3600

ggggggcagg gaactgtcat tcattttgca caattcttga actgatgtca gcacccgagt     3660

ggctcctgaa tttaagtctg ggacgacatc ttttattttt acatgaatct ttaaacaatt     3720

ctgtgagcaa agtttgtagc tgctggatta ttgtctgtct ttatagcaag ttccagtaaa     3780

ccacaagtat ggcaaagctt atccaatttt atgcttggag cagtcagtac ataccagttt     3840

ctgatgtttc aggcaggagt ggggtaaata agtgtgacca cttaaagctg ctcgttagca     3900

tggaagactt ctccattcta tctttgtaaa acagacaaga tatgcacttg acatagtagc     3960

aaattggttc tgaattatgc aactgtttgc tatttagtaa actagcaaat gatgcatgta     4020

ttttgttttt catgtactgg gcaatatgag taaaatctgt ccctttttcc ccctttgaat     4080

gaggtcttcc atgtttgagg gaaagtcttg cactattgca tatattttgg ggacacagat     4140

tttcatagtt tccatttttg gggggcttaa ggattttttt tttttctgtt tgaaacagtt     4200

ttatactttc tgatatagta cttgaaattc ttaccagaaa attactttgg agttttgaag     4260

cctttattaa tactactttt aaagaagcag ttgttttatt gtcaatgttt tttttccccc     4320

aagcatattt tcttgtattt ctgtttccat atatatatat atatatataa tttccaattc     4380

aggatattgc cctgccatcc atgaaaactg ttctggcacc aaaagtaatg acaaatgtta     4440

agtgtaataa tagaaaagta gagcaaagag ccattcagct tcagtcttta cataccatga     4500

ataaaacatt aaaacatcat atggagaagt ttacatggtg attgttcacc tgcagtactg     4560

tggagtttta acattttgtc ctcttttcag tgaaacagag taaaaatatt catctaccat     4620

tactgttatt tgctgatttt gttttatttt ttgatggtaa tattctatcc ttatgacact     4680

attgcaacca aattggcttt accatcttgg ctttagtagg tatagaagac aatggattac     4740

catctttatt gctgtaatgt gttaagcatt atatgctagt agaatctagt ttaattgttt     4800

caggtggaaa gtattctttg agtttccata ttgaatgtgt ttggactaaa caaacaataa     4860

actactgatg tctgcagcat tta                                             4883


<210> 1471
<211> 818
<212> DNA
<213> Homo sapiens

<400> 1471
gcggcggcgg caccatgagc ggccggaagc gcagcttcac cttcggggcc tacggcgggg       60

tggacaagtc cttcacttct cgccggagtg tgtggaggag cgatgggcag aaccagcact      120

tccctcaggc actagacctg tcacgagtga acttagttcc ctcctatact ccttcactct      180

accctaagaa cacagatcta tttgagatga ttgagaagat gcagggaagc aggatggatg      240

aacaacgctg ctccttcccg ccgcccctca aaacagagga ggactacatt ccatacccga      300

gcgtgcacga ggtcttgggg cgagaaggac ccttccccct catcctgctg ccccagtttg      360

ggggctactg gattgagggc accaaccacg aaatcaccag catccccgag acagagccac      420

tgcagtcgcc cacaaccaag gtgaagctcg agtgcaaccc cacagcccgc atctaccgga      480

agcactttct cggcaaggag catttcaatt actactcact ggacgctgcc ctcggccacc      540

ttgtcttctc actcaagtac gatgtcatcg gggaccaaga gcacctgcgg ctgctgctca      600

ggaccaagtg ccggacatac catgatgtca tccccatctc ctgcctcacc gagttcccta      660

atgttgtcca gatggcaaag ttggtgtgtg aagacgtcaa tgtggatcgg ttctatcctg      720

tgctctaccc caaggcttcc cggctcatcg tcacctttga cgagcatgtc atcagcaata      780

acttcaagtt tggcgtcatt tatcagaagc ttgggcag                              818


<210> 1472
<211> 2965
<212> DNA
<213> Homo sapiens

<400> 1472
gcactccagg agcagccgcg ccgctgctca cccgccctgt agtccgctcc ccccagggcc       60

gtccccgttt taagaaatgg ggtgatgggg cgtccctacc cggcgcctgc aggggctcct      120

ggggagcgcg ccggtggctc gctgctcccg ggtggggcgc ggggctggcg ctcgagggtg      180

ccgtggccca ggcggggctg cagcgagtgt gttccccgtt ccgcgcgcgt gaagcgtggg      240

agcgaagcct cgggggaggg cgggagcgcg gctgagctca ctgtgaacac ccggctgggt      300

agtcccgcga gcaggggagg ggccggaacc gatgtgtatg cggagaggtc gcagtcattg      360

ctgtgagcag gacacagtgg cggctgacct gggagaagtt acagagggac ggggtgggag      420

agggacgagg agtcgggaat ggcccccagg ctctcgtcct gagcggtcgg ctggacgtgg      480

ggcgccactg accaccgtgg agaagcccgg gggaggggag gtgctttctg gctgcacact      540

gacctatgtt ggggtgccca gggcaggatg tacacgctgc tgtcgggctt gtacaagtac      600

atgtttcaga aggacgagta ctgcatcctg atcctgggcc tggacaatgc tgggaagacg      660

accttcctgg agcagtcgaa aacccgattt aacaagaact acaaggggat gagtctatcc      720

aaaatcacca ccaccgtggg cctaaacatc ggcactgtgg atgtgggaaa ggctcggctc      780

atgttctggg acttaggagg gcaggaagag ctgcagtctt tgtgggacaa gtattatgcg      840

gagtgtcacg gcgtcatcta cgtcattgac tccaccgacg aggagaggct ggctgagtcc      900

aagcaggcgt ttgagaaggt ggtgaccagc gaggcgctgt gcggtgtccc cgtcttggtg      960

ctggccaaca agcaggatgt ggagacgtgc ctctcaatcc ctgacatcaa gacggccttc     1020

agcgactgca ccagcaagat cggcaggcga gattgcctga cccaggcctg ctcggccctc     1080

acaggcaaag gggtgcgcga gggcatcgag tggatggtga agtgtgtcgt gcggaatgtg     1140

caccggccgc cgcggcagag ggacatcacg taggcgcagc cgcgctgccg tcgggacggc     1200

tggtcccctg gtgctggagg agtggcctcc tgttggctcc catgctgctg atctgggggg     1260

tgggtttgct ttgctttggg gttcttctat ttactttgtt ttctcgaaga caaactttcc     1320

tctatgtctg gaaaagcgta ggcatccgga ggctttggag gggagtctgg cagcccggct     1380

ggcccaggcc ctgcagcggc agcctttcca cagggcgcag cggcggcctt tcgaggccct     1440

ttctgggggg tctgagggag acctggttgg gaattggggc tccagtgctc aggctggctt     1500

gggctgcatg aggacagccc tgtgggaccc tcgggagacc ccgtggctgt ctccgcccca     1560

tcgaggagga ggcccgtcag ccatggctgc catctggctt ctgccctgtg accccgtgac     1620

cccgtgaccc cgaagtggtc tggggctgat cttgccttga ggaagaccca ggccatgttc     1680

ccaaaggcca gcgggggccc tggattgtga tgcagcctcg ggacagggct gaggcctgcg     1740

ggggaagacc tataccccac gcctgggcct ggcttcacct caccctaatc ccccgggagg     1800

gagctgactg atgcaaaaag ctgagggggc ctgctgggag tggctgtttt tatgccccag     1860

ccccgcaagt tggggagtgt ttgtgggggt ccagagccct cccccagcca ggagagaacc     1920

tcccggaggg gttctctgtg gggccctgtg tcccctgctc gggagtaagg ctggtcctgg     1980

ggtcctccct gcacggaccc cactgggcct gccgagtgct gtgttcttcc tcagtctggc     2040

tgtgggcagg agcggcctgc ccagtgtcac ccagggtgag tgcaaaataa agacggcgag     2100

tgtggctctg tccatccctt ccctcctgga gggtggaggc tcctggctgt tggacacggt     2160

gatggtgtta ctgggctgct caggggctgg tgggcaggtg aggggctccc caggtgggcc     2220

tggagagtcc aggcactccc ttcctgcgga tgtgggaagg acatggggtc ctgggaggag     2280

ctgctgggaa ggggcatgag tcagggtggg ggtggcgcag cagctgcggg gctgtgactc     2340

acaggagtcg ggccctggaa gtccccgcgt cctctccagg ggaccctgtg tgtgttctgc     2400

aggttggttc ccaggacctg ggggggacct ccagccccgg gaacctggcc gtgctgggga     2460

ggcgagtggc tggtgcagcc ccccggttgc tctgggtgca tcgggaggct tcagagcctg     2520

ccccagagag ggagaagctt cacttcccgg aaagcatggg aggcctggag gaggtctttg     2580

gcaggtcccc tctcgggaaa tcccctgtga gttgggagtg ggaggaattc ataagtgggg     2640

ggttagtgtg ggccccggcg actagggctg gcctgagccc catcctgttc ttccagcaat     2700

gataccctcc caggccctga ccctcgctga gcttcagggg cccctgccac gtgccacagc     2760

cactgggggc agaggtggca ctccccactg atcctcccag ggagggtctg tctgaggtag     2820

gggaagcccc gggcagcagt tctgatggca ggcagcctga gggatctggg cacagcgggc     2880

ggctcaggtg tccccggctg ccctcccagt agctgtgcaa ctacaaccag ttttatgaaa     2940

aagctttata aaaataagct ttaag                                           2965


<210> 1473
<211> 2209
<212> DNA
<213> Homo sapiens

<400> 1473
agcagacaag atggcttccg ggatttggcg gcgcctttgt ctctcgctgc agccggagct       60

ccaggtctcg ctttcattgc tctgtgtcct ctgctcctag aggtccagcc tctgtgggcc      120

tgtgacctgc agaaattgag agatccacag ctaagactcc aggaccccct ggaagcctag      180

aaatgggact gttgacattt agggatgtgg ccatagaatt ctctctggaa gaatggcaat      240

gcctggacac tgcacagcgg aatttatata aaaatgtgat tttagagaac tacagaaacc      300

tggtcttcct gggtattgct gtctctaagc aagacctgat cacctgtctg gagcaagaaa      360

aagagccttt gactgtgaag agacatgaga tggtgaatga acccccagta atgtgttctc      420

attttgccca agagttttgg ccagagcaga acataaaaga ttcttttgaa aaagtgacac      480

tgagaagata tgaaaaatgt ggaaatgata attttcagtt aaaaggctgt aaaagtgtgg      540

atgaatgtaa gttgcacaag ggaggttata atggacttaa ccaatgttta ccaactatgc      600

agagcaaaat gtttcaatgt gataaatatg tgaaagtctt taataaattt tcacattcag      660

atagacataa gataaaacat atggaaaata aacctttcaa atgtaaagaa tgtggcagat      720

cattttgcat gctttcacac ctaactcgac atgaaagaaa ttataccaag gtgaatttct      780

gcaaatgtga agaatgtgaa aaagctgtta accaatcttc aaagcttact aaacataaaa      840

gaatttatac ttgtgagaaa ctctacaaat gtcaagaatg tgacagaact tttaaccaat      900

tctcaaacct tactgaatat aaaaaagatt atgctcgaga gaaaccatac aaatgtgaag      960

aatgtggcaa agcctttaac cagtcctcac accttactac acataagata attcatacag     1020

gagagaaacc ctacaaatgt gaagaatgtg gcaaagcctt taaccagttc tcaaatctta     1080

ctacacataa aaaaattcat actggagagc aaccctacat atgtgaagaa tgtggcaagg     1140

cttttaccca atcctcaacc cttactacac ataagagaat tcatactgga gaaaaaccct     1200

acaaatgtga agaatgtgga aaagctttta accgatcctc aaaacttact gaacataaaa     1260

acattcatac tggagagcaa ccctacaaat gtgaggaatg cggcaaagct tttaaccgat     1320

cctcaaatct tacggaacat aggaaaattc ataccgaaga gaaaccctac aaatgtaaag     1380

aatgtggcaa agcttttaaa cactcctcag cccttactac acataagaga attcacactg     1440

gagagaaacc ctacaaatgt gaagaatgtg gcaaagcttt taaccgatcc tcaaaactta     1500

ctgaacataa gaaacttcat actggaaaga aaccctacaa atgtgaagaa tgtggcaaag     1560

cttttatcca atcctcaaaa cttactgaac ataagaaaat tcattctgga gagataccct     1620

acaagtgtga agaatgtggc aaagctttta aacactcctc atcccttact acacataaaa     1680

gaattcatac tggggagaaa ccctacaaat gtgaagaatg tggcaaagct tttagccgat     1740

cctcaaaact tactgaacat aagataattc atactggaga gaaaccctat aaatgtgaga     1800

gatgtgacaa agcttttaac caatctgcaa accttactaa acataaaaaa atacatactg     1860

gagagaaact acagaactgg aatgtgtgat aatgattttg acaacacctc aaatttttct     1920

aaatataaag gaaatcatac tggtgaaaaa ttctagaaat gtaaagaatg tgtcaaagac     1980

tttaaatggt tttcacactt cattgtatgt aagataattc atactggaga aaactacaag     2040

tgtgaagaat ttggcaatac tgttaattaa ggctcaaacc ttattgcaca ggaaagcgtt     2100

tatacttaag aaaaattgta caaatataaa gagtgtaaaa tagccattaa tatctgttga     2160

catcttaata tcagaatgtt ggtacttaat aaaagcatta taaatgcaa                 2209


<210> 1474
<211> 2515
<212> DNA
<213> Homo sapiens

<400> 1474
aaaatggatc ctcacttctt cacttggata taataatata gactgccgac attctgggaa       60

ctgatcagtc ttccagcttc cagtgtggtg ccctccctca attgtgctga gtgtccccca      120

atccagagat attctgtaat ttcttcctca gaaagaaaca aaacaaaatt ctgatcttcc      180

cagatgaaga taatggattc tgaattaatg catagtatag taggaagcta tcataaacct      240

ccagaaagag tatttgttcc ctcattcacc cagaatgaac catctcagaa ttgccatcct      300

gcaaacttag aagttacctc tcctaagata cttcatagcc caaatagcca agctcttatt      360

ttagccttaa aaactcttca ggaaaaaatt catcgtttag agctggagag aacacaagct      420

gaagataacc tgaacattct ttccagagaa gcagcacagt ataagaaggc cttagagaat      480

gaaacaaatg agagaaatct ggcacaccag gagctgataa agcagaaaaa agatataagt      540

atacagttaa gctcagccca gtctcgttgt actcttctag agaagcaact agaatataca      600

aagagaatgg ttctcaacgt agagcgagaa aagaacatga tcctagaaca acaggcccag      660

cttcagaggg aaaaagaaca agatcagatg aagctgtatg caaaacttga aaagcttgat      720

gtcttagaaa aagagtgttt cagacttaca acaactcaga aaactgctga ggacaagatt      780

aaacatttag aagaaaaact taaggaagaa gaacatcagc gtaagctatt tcaagacaaa      840

gcttctgagc ttcaaactgg acttgaaatc agtaaaatta taatgtcttc agtttcaaat      900

ctaaagcact ccaaggaaaa gaagaaatct tcaaagaaaa ctaaatgtat aaagagacga      960

ccaccttggc aaatttgttc aaagtttgga gcactgcctt ttgtggctga aaagatgagg     1020

caacatcgtg acccacatat ccttcagaaa ccttttaacg tgactgagac tagatgtctc     1080

cccaagcctt ctagaacaac ttcctggtgt aaagctattc ctcctgactc agaaaagtcc     1140

atttccattt gtgacaattt atctgaactt ttgatggcaa tgcaagatga gctggaccaa     1200

atgagcatgg agcaccaaga actactgaaa caaatgaagg aaactgaaag tcattcagtc     1260

tgtgacgaca tagaatgtga actagagtgt ttactcaaga aaatggaaat taaaggagaa     1320

caaatctcca aactgaagaa gcatcaagac agtgtctgta aactgcagca aaaagttcaa     1380

aactcaaaga tgagtgaagc ttcaggtatt cagcaagaag acagctaccc taaaggatca     1440

aagaacataa aaaatagccc cagaaaatgt ttgactgaca ctaacctttt tcagaaaaac     1500

agcagctttc atccaatacg agttcataat cttcaaatga aattgagaag agatgatatc     1560

atgtgggaac agtaacaaaa cagcaaaact gtcaccttaa tgaactttgt cagtgagacc     1620

ttgaattgtc taaagtggtt ttaatttaat ataactttgt gacattttga atcatgtttc     1680

tagtttctat aaaacatgaa gttgcagtat ttaaaaatta atgcctaatg acctggtggg     1740

ttccaaataa taaattaatt gcttttttat ttttcttatt gattgaagcc cgtaacctca     1800

tcttgtctta gaaacattgt tggctttgca gatatcttaa gctaaattta agaaattgta     1860

ctagattgac aatattcaaa attgagttaa atccaagcta caagtaccat tcattccact     1920

tttcatttag taggtttgga accttaaaaa ccaatgttca atgaacagag ttcagaaaga     1980

tcatttagct ttcctggtgc cttctttcta ttttgtttta gagctgtgaa atgtttttct     2040

cttttggaaa aggaaaaact taatagttac acagttttgt gaagaagcct ttaatccaag     2100

ttttatgaga cagtaggaac ctatagctac ttaattttta ggagacagta attcagttgc     2160

agaagctttc ctctgctatt cccattctct tttacaaaac tagttttttt taaaaaatca     2220

atgatcaatt ttatcttact actttataac ttttgctgac ttttattctt tgcattgtat     2280

gtaatgtcca tcagtataaa ttgagactgt gaatttctag gacccacaaa agtggtattt     2340

tttttttgta caagaaagta tagaggaaga ggaagctggg cattaaatta cctcatccag     2400

cagaaattca cggtagtatg gtatattttt attttttata ttttaaaatc aataatgtca     2460

aatgtcattg tgtatgcatg ctttataata aatttacact tgatcatttt tctgg          2515


<210> 1475
<211> 2475
<212> DNA
<213> Homo sapiens

<400> 1475
agcaagggaa gtgacaggaa atggagctgg ggagacaaaa atgtggataa caacaaaaga       60

atttcaacag gtaaaaaaat gagtcaaaca tctctcaaac agaaaaagaa tgagcctgga      120

atgaggtcct caaaagagag tctagaagca gaaaaaagaa aggaatctga caaaacagga      180

gttcgtctga gcaatcagat gaggcgtgca gtcaatccga atcactcgct gagatgttgc      240

cccttccagg gtcactcgtc gtgtagacgc tgcctttgtg cagctgaggg aacagccctt      300

ggcccctgcc acacaatacg tatttatatt cacatgtgcc tgttgtggga gcagggccag      360

cagatcacca tgatgagggg atcacaagaa tcatcactgc ggaagacaga ctctcgaggg      420

taccttgtgc gcagtcaatg gtctagaata tcccggagcc catccaccaa ggctccatcc      480

atagatgagc ctagaagcag gaacaccagt gctaagctcc ccagcagctc cacgagctcc      540

cggactccat ccacctcccc aagcctgcat gactcctcac cgccgccgct gtccgggcag      600

ccctcgctcc agccacccgc gtcgccccag ctgccccggt cgctggactc gcggcctccc      660

acgcccccag agcccgatcc tggctcccgg cgcagcacca aaatgcaaga gaatccggag      720

gcctgggccc aaggcatcgt gcgggaaatc cgccagaccc gggactcgca gccgctggaa      780

tattcgcgca cgtcccccac cgagtggaag tcctccagcc agcgcagggg gatctacccc      840

gcctccaccc agctggaccg caactctctg tccgagcagc agcagcagca gcgggaggac      900

gaggacgact acgaggctgc ctactgggca tccatgaggt cgttctacga gaagaacccg      960

agctgctcgc gcccctggcc gcccaaaccc aagaacgcca tcaccattgc tctctcatcc     1020

tgcgcgctct tcaacatggt ggacggcagg aaaatctacg agcaagaggg tctggaaaag     1080

tacatggagt atcagctcac caatgagaac gtcatcctga ccccgggccc ggcgttccgc     1140

ttcgtcaagg cactacagta tgtcaatgct agactccgtg atctatatcc tgatgaacag     1200

gacttatttg atattgtact gatgactaat aaccatgccc aagtgggagt gcggcttata     1260

aacagcgtca atcactacgg cttactgatt gaccgcttct gtctgaccgg gggaaaagac     1320

cccattggct atttgaaggc atatcttacc aacttgtata ttgctgcaga ttctgaaaaa     1380

gtgcaagagg caatacaaga aggtattgcc tctgcgacaa tgtttgatgg agccaaagac     1440

atggcttact gtgacactca gctccgtgta gcctttgatg gggatgctgt cctcttctct     1500

gatgagtctg aacattttac caaggagcat gggctcgaca aattcttcca gtatgataca     1560

ttatgtgaaa gtaagcctct tgctcagggt cccctaaaag gctttctgga agatttaggc     1620

agactgcaaa agaagttcta tgccaaaaat gaacggttac tttgtcctat caggacctac     1680

ctggttacag ctaggagtgc agccagttca ggcgcccgtg tgctgaagac ccttcgacgc     1740

tggggtctag agatagacga agctcttttc cttgctggag cccccaaaag tcccatcttg     1800

gtgaagatcc ggccccacat cttctttgat gaccacatgt tccacattga aggggcacag     1860

aggttaggtt ccatcgcagc ttatggcttt aataaaaaat tcagtagtta ggggcaggga     1920

ggagaaataa agtggtgata gtctggtgtt acagaagcca cttcttttgg ctctctagga     1980

taattagata ggtatttcag aaaattggac cttaaaactt tgcttctttg gaaaggtttt     2040

ctcctgattt tttggaaaac cttttgaacc ctcaagttac catcaaacta cttctctttg     2100

aactaccaat actgttgaat gccattacac ctatctctgt gtaagtcata atgatgactc     2160

tttaggataa gtttagaact tgaatatttg catgcttaag gcactgtttt agaagcttac     2220

ttagttttat aaacactgct catttttgga tgtttgtaga taacaatgaa ttgttaccca     2280

tcagcattgt agaatagtgt cttcaaaggt agaaggagta tggttaagca cactcttgaa     2340

aactggagct ttgtattctg tgactgctat ggctagcttt gtaaccaaag caaaatgaga     2400

atttcactct acctgcatga gtataacaat tttgatactg ctcatttaga aataaatcat     2460

ctggttgttc ctcca                                                      2475


<210> 1476
<211> 1838
<212> DNA
<213> Homo sapiens

<400> 1476
gctgggctgg gcttgctgag gtagaggcag cgccaagaag aggcctttgc cgctggtcgg       60

gattgggatg tcgaagaaca cagtgtcgtc ggcccgcttc cggaaggtgg acgtggatga      120

atatgacgag aacaagttcg tggacgaaga agatgggggc gacggccagg ccgggcccga      180

cgagggcgag gtggactcct gcctgcggca aggaaacatg acagctgccc tacaggcagc      240

tctgaagaac ccccctatca acaccaagag tcaggcagtg aaggaccggg caggcagcat      300

tgtcttgaag gtgctcatct cttttaaagc taatgatata gaaaaggcag ttcaatctct      360

ggacaagaat ggtgtggatc tcctaatgaa gtatatttat aaaggatttg agagcccgtc      420

tgacaatagc agtgctatgt tactgcaatg gcatgaaaag gcacttgctg ctggaggagt      480

agggtccatt gttcgtgtct tgactgcaag aaaaactgtg tagtctggca ggaagtggat      540

tatctgcctc gggagtggga attgctggta caaagaccaa aacaaccaaa tgccaccgct      600

gccctgtggg tagcatctgt ttctctcagc tttgccttct tgctttttca tatctgtaaa      660

gaaaaaaatt acatatcagt tgtcctttaa tgaaaattgg gataatatag aagaaattgt      720

gttaaaatag aagtgtttca tcctttcaaa accatttcag tgatgtttat accaatctgt      780

atatagtata atttacattc aagtttaatt gtgcaacttt taacccctgt tggctggttt      840

tttgttctgt tttgttttgt attattttta actaatactg agagatttgg tcagaatttg      900

aggccagttt cctagctcat tgctagtcag gaaatgatat ttataaaaaa tatgagagac      960

tggcagctat taacattgca aaactggacc atatttccct tatttaataa gcaaaatatg     1020

tttttggaat aagtggtggg tgaataccac tgctaagtta tagctttgtt tttgcttgcc     1080

tcctgattat ctgtactgtg ggtttaagta tgctactttc tctcagcatc caataatcat     1140

ggcccctcaa tttatttgtg gtcacccagg gttcagagca agaagtcttg ctttatacaa     1200

atgtatccat aaaatatcag agcttgttgg gcatgaacat caaacttttg ttccactaat     1260

atggctctgt ttggaaaaaa ctgcaaatca gaaagaatga tttgcagaaa gaaagaaaaa     1320

ctatggtgta atttaaactc tgggcagcct ctgaatgaaa tgctactttc tttagaaata     1380

taatagctgc cttagacatt atgaggtata caactagtat ttaagatacc atttaatatg     1440

ccccgtaaat gtcttcagtg ttcttcaggg tagttgggat ctcaaaagat ttggttcaga     1500

tccaaacaaa tacacattct gtgttttagc tcagtgtttt ctaaaaaaag aaactgccac     1560

acagcaaaaa attgtttact ttgttggaca aaccaaatca gttctcaaaa aatgaccggt     1620

gcttataaaa agttataaat atcgagtagc tctaaaacaa accacctgac caagagggaa     1680

gtgagcttgt gcttagtatt tacattggat gccagttttg taatcactga cttatgtgca     1740

aactggtgca gaaattctat aaactctttg ctgtttttga tacctgcttt ttgtttcatt     1800

ttgttttgtt ttgtaaaaat gataaaactt cagaaaat                             1838


<210> 1477
<211> 5740
<212> DNA
<213> Homo sapiens

<400> 1477
aaacaccatg ccctgccatc tctgggtctt agagtcaccc taacatctga tctagattaa       60

ttatcatcat gtgcgaggtt ttggcatgaa gcacgccagg ctcaccgttt catgatctta      120

gactatttac agcaaactca aacagctcac ttgcttttta caccctgcaa agaccaaggg      180

agagcctgga ggggttgttt tttttttctg ttttattcta tcaaagcagc aaatactgca      240

atttccacag taaatggtca cagtggggac caatatcctg ccctccagac ccgctgcttc      300

agccaataca gcaagggaag acgcagctct gttttctaga aggatcccac cgaggcataa      360

aaacggcgca gcccagcctg gcgccgcgcc gggtcccgga gccccgggcg cgaacatggg      420

gaatgcgcac tccaaaagcg gggacaggca cagcgcgctc cccggccgcc ccgagctgtc      480

tttttacggc tctttcccca ggaaatggag cgagaacgtc ttcttggata acgagctgct      540

gacctccaag atcctgtctg tgctgcggcc gcagtcggag cggggcttcc gcgccgggga      600

cctccgctac ccgacccact ttctcagcac caactctgtc cttgcctctg tcacagcctc      660

gctcaaggag cacccccggg gcaccctcct gtccgatggc agcccggccc tgtccaggaa      720

tgtcggtatg acggtctctc agaaaggggg tccccagcca acaccgagcc cggctggccc      780

tgggacgcaa ctcggaccaa tcacaggaga gatggatgaa gccgattctg cgtttttaaa      840

atttaagcag acagctgatg actctctgtc ccttacatct ccaaacaccg agtccatttt      900

tgtagaagat ccctacaccg cctcgctgag gagtgagatt gagtcagacg gccacgagtt      960

tgaagctgag tcctggagcc tcgccgtgga tgcagcctac gccaagaagc aaaagaggga     1020

ggtggtgaaa agacaagatg tcctttatga gctgatgcag acagaggtgc accacgtgcg     1080

gacgctcaag atcatgctga aggtgtactc cagggccctg caggaggagc tgcagttcag     1140

cagcaaggcc attggccgcc tcttcccatg cgctgacgac ctgctggaga cgcacagcca     1200

cttcctcgct cggctcaagg agcgccgcca ggagtccctg gaggagggca gtgaccggaa     1260

ttatgtcatc cagaaaatcg gcgacctcct ggttcagcag ttttcaggtg aaaatgggga     1320

gagaatgaaa gaaaagtacg gtgtgttttg tagtggccac aatgaagctg ttagtcatta     1380

caagttgctg cttcagcaaa acaagaaatt tcaaaacttg atcaagaaaa ttggcaactt     1440

ctccatcgtg cggcggcttg gcgtgcagga gtgcattctc ctggttacac aacgcataac     1500

caaataccca gtgctggtgg agcgcatcat ccagaacacg gaagctggca ctgaggacta     1560

tgaagacctg acccaggcct tgaacctcat caaagatatc atctcacaag tggacgccaa     1620

ggtcagtgag tgtgagaagg gccagcgcct cagggagatc gcagggaaga tggacctgaa     1680

gtcttccagc aaactcaaga acgggctcac cttccgcaag gaagacatgc ttcagcggca     1740

gctccacctg gagggcatgc tatgctggaa gaccacatca gggcgcttga aagatatcct     1800

ggctatcctg ctgaccgacg tacttttgct gctacaagaa aaagatcaga aatacgtctt     1860

tgcttctgtg gactcaaagc cacccgtcat ctcgttacaa aagctcatcg tgagggaagt     1920

ggccaacgag gagaaagcga tgtttctgat cagcgcctcc ttgcaagggc cggagatgta     1980

tgaaatctac acgagctcca aagaggacag gaacgcctgg atggcccaca tccaaagggc     2040

tgtggagagc tgccctgacg aggaggaggg gcccttcagc ctgcccgaag aggaaaggaa     2100

ggtggtcgag gcccgcgcca cgagactccg ggactttcaa gagcggttga gcatgaaaga     2160

ccagctgatc gcacagagcc tcctagagaa acagcagatc tacctggaga tggccgagat     2220

gggcggcctc gaagacctgc cccagccccg aggcctattc cgtggagggg acccatccga     2280

gaccctgcag ggggagctaa ttctcaagtc ggccatgagc gagatcgagg gcatccagag     2340

cctgatctgc aggcagctgg gcagcgccaa cggccaggcg gaagacggag gcagctccac     2400

aggcccgccc aggagggctg agaccttcgc gggctacgac tgcacaaaca gccccaccaa     2460

gaatggcagt ttcaagaaga aagtcagcag cactgacccc aggccccgag actggcgagg     2520

ccccccaaac agcccggact tgaagctcag tgacagtgac attcctggga gctctgagga     2580

atcgccgcag gtggtggagg cgccaggcac ggaatccgat ccccgtctgc ccaccgtcct     2640

ggagtcggag cttgtccagc ggatccagac actgtcccag ctgctcctga accttcaggc     2700

ggtaatcgcc caccaggaca gctatgtgga gacgcagcgg gctgccatcc aggagcggga     2760

gaagcagttc cggctgcagt cgacgcgtgg gaacctgctg ctggagcagg agcggcaacg     2820

caacttcgag aagcagcggg aggagcgcgc ggccctggag aagctgcaga gccagctgcg     2880

gcacgagcag cagcgctggg agcgcgagcg ccagtggcag caccaggagc tggagcgtgc     2940

gggcgcgcgg ctgcaggagc gcgagggcga ggcgcggcag ctacgcgagc ggctggagca     3000

ggagcgggcc gagctggagc gccagcgcca ggcctaccag cacgacctgg agcggctgcg     3060

cgaggcccag cgtgccgtgg agcgcgagcg ggagcgcctg gagctgctgc gccgcctcaa     3120

gaagcagaac accgcgccag gcgcgctgcc gcccgacaca ctggccgagg cccagccccc     3180

aagccaccct cccagcttca acggggaagg gctggagggc cctcgtgtga gcatgctgcc     3240

atccggcgtg gggccagagt acgcagagcg ccccgaggtg gctcgccggg acagcgcccc     3300

caccgagaac cggctggcca agagcgatgt gcccatccag ctgctcagcg ccaccaacca     3360

gttccagagg caggcggccg tgcagcagca gatccccacc aagctggcgg cctccaccaa     3420

gggtggcaag gacaagggcg gcaagagcag gggctctcag cgctgggaga gctcagcgtc     3480

cttcgacctg aagcagcagc tgctgctcaa caagctcatg gggaaagatg agagcacctc     3540

acggaaccgc cgctcgctga gccctatcct gcccggcaga cacagtcctg cgcccccacc     3600

agaccctggc ttccccgccc cgagcccacc gccagctgac agcccctccg agggcttctc     3660

tctcaaggcc gggggcacag ccctcctgcc cgggccccca gctccctcgc cactgccggc     3720

cacaccactc agcgccaagg aggacgccag caaagaagac gtcatcttct tctaaaaggg     3780

ccgtgactca aggaaagttt ttaatggaaa gttgagccag aactaaacca gggagctgtc     3840

tgaaatcata gcaccccatc cgggtggcgg ggagatcaac tccgagctgt ttttccgagg     3900

cagtgaggaa cggtgccggc tctgcacgga gctgaggaca ggacagacct tgctttgaga     3960

aggagctgcc ggccggggcc acgctccaca gccgccgcgc gacagtggag ccaagggtta     4020

gggcaccagg aggggccagg tggcgtcggc agcatctgtc cccagaatca ggcagaatcc     4080

acttcccaaa cagagcccca cgcaggttca ccatgaacct cagggtcagg gaatgagcca     4140

ggcacggggg catgggcaga gagggccacg gggcagggcc cactgaggga acatcagtgg     4200

ccctccagtc aggttctgtg ggtttggaag cccatcgtga aaggggctga cctttgcccc     4260

tttttacttg gcattggttt tgaaaccagc tgtttcccaa actctgcttc ccaagggcaa     4320

ccgttgctgt tcacacgctc agcctgtctg ggggagcggg cctctagctt cagccagggc     4380

gggtacacac cctgggcaca gggtcctcag cccccgggaa atgagctccc agggctggcg     4440

tcccaccttc caggtggggg ctggcacatc acagactgtc gagagcgcca tgtcccaggg     4500

catgcagagg atgcacctag agacgttgca gcaagtggac aagtggccgc tgtgcgggcc     4560

cctcgcttgt agtgagctgt tgcagcttac ggtccgttcc ctggaggggt ggaggaagga     4620

ggtgttgggc agcatcaaag gtgctgggac atcccagggt ggtgagatcc atccacgatc     4680

cagctccggt ggagaaaggg cccatgtcaa gccttgttct gcaccccaag cattggtggt     4740

aggactgggt cctggctgat cgtccttgtt cccagtgggg tacatgtgag cccctgccag     4800

ggccaagtcc ttctcccgaa cccagggtcc tgggaactgc agatcccggg gggattcagc     4860

ccttctccca ctgtgctggc agaggcactc ctgtgacgct gaatacagtg aacagggaca     4920

ttcccgccac tcggggacag atgggcacaa gggaggggaa actccatcag gaagtgctcc     4980

cctgggcaga ggcgcccact gggtgctgtg ggctcaggag ggggcggggc aggagctggt     5040

gccaaccggg aaccagagcc ccacagccat acagcccatt ggtgacaagg tcctgagaac     5100

acagtggcca ggtgtcccca ggctcctggc ccctccgacg acctcaactc tgcccagccc     5160

ggtccctggc catcagcgac gctgtccgcc ccccgtcaga tcccatgtgt gccatgttta     5220

tcatcagtgt tttgtatttt tgtactgagt atcggagcac tttacagaag ctgactgtac     5280

attcctgttc tgttgtgaag agaacattcc cagaccctgg caccctcctg agccggcgtg     5340

tgccggtcca gccctccgag atgccacaat tccttggatg ggggagaagt tcaaggaatt     5400

tctgctcggc cacgcggtgg gaaccccgcg tccccgccat gtggcagagg ggtctcagtc     5460

gtgctaggca tcgggcggca gcgccgacag cccttccctc gccagtgccc ctcggccact     5520

cctgggttgg agcccgattt tatttgtaaa gttgacagtc gagcaaatgt tcctattttc     5580

gtgggatctg cacacgtctt tgtcagttgt ggtcatgatc ttagtcacct gctaattatt     5640

tttacaatga ttacaacatt tcctcactgc gggatatttc tgacccgctt tagaacttaa     5700

gacctgattc tagcaataaa cgtgtccgag atgagcggtg                           5740


<210> 1478
<211> 2034
<212> DNA
<213> Homo sapiens

<400> 1478
gttgagaggc cccaagaccc agttccttta cagaatcaac cctggggtgg ctttaggact       60

gggctctttg gagctcatcc ttggacccac agtggagtgc tggtccgtgc tgatgtcttc      120

agataccaat caatgggcat ttggctcctt gcttccactg acctcttgag tactttcaac      180

gatcggtgtc aggagtgccc cagctgctgt ttctagagca tctctgcaac ccacggtggc      240

ctctcctctc tctgcgggcc atggacagca cagtcccttc agccctggag ctgccccagc      300

ggctggcact gaacccaagg gagagcccga ggagtccaga agaggaggag ccccacctgc      360

tgagcagctt ggctgcagtc cagaccctgg ccagtgtcat ccggccttgc tatggccccc      420

acggccggca gaagttcctg gtgaccatga aaggagaaac agtgtgcacg gggtgtgcca      480

ctgccatcct cagggccctg gagctggagc acccagcagc atggctcctc cgggaagcag      540

gacaaaccca ggcagagaat agtggggacg gcacagcctt cgtggttctg ctgacggaag      600

ccttgctgga acaggcagag cagctgctga aggctggcct gcctcgcccg cagctccggg      660

aggcctacgc cacggccact gcagaggtcc tggccacact gccctccctg gccatccaat      720

ctctggggcc tttggaagat ccatcctggg ccctccattc tgtgatgaat acccacaccc      780

tgtcccccat ggaccacttg accaagctgg tggcccacgc ctgctgggct atcaaggaac      840

tagacggcag cttcaagcct gagcgtgttg gggtgtgcgc gctgcccggg gggacactgg      900

aggattcctg cctcctcccg gggttagcaa tatctgggaa gctctgtggg caaatggcca      960

cagtgttaag tggtgccagg gtggctctct ttgcttgccc ctttggtcct gcccatccaa     1020

atgcaccagc aacggcccgt ctttctagtc ctgctgatct agctcaattt agtaaaggaa     1080

gcgatcaatt actagaaaag caagtaggcc agctagcagc tgcaggaatt aatgtggcag     1140

tggtgttggg ggaggtcgac gaggagaccc tcacactggc ggacaagtat ggcatcgtgg     1200

tgattcaagc taggtcttgg atggagatca tttacctgag tgaggtgttg gacacacctc     1260

tgctgcctcg tctgctccct ccccagaggc caggcaagtg ccagagggtt tacaggcagg     1320

agctgggaga tggtttggct gtggtatttg aatgggaatg tacaggcaca cctgccctca     1380

ctgtggttct caggggagcc accacccagg ggctgcggag tgcagagcag gccgtctacc     1440

acggcattga tgcctatttc cagctatgtc aagatcccag actgattcca ggagctgggg     1500

ccacagaaat ggctttggca aaaatgcttt ctgataaagg aagcagattg gaagggccca     1560

gtgggcctgc attcctagca tttgcctggg ccctgaagta tcttcctaaa actttggcag     1620

agaatgcagg cttagctgtc tcagacgtga tggcagaaat gagtggagtg caccaaggtg     1680

ggaacctcct aatgggtgtg ggaactgaag ggataataaa tgtggcccag gaaggggtgt     1740

gggacaccct aatagtcaaa gcccaaggat ttcgagcagt ggctgaggtg gtgctacagc     1800

tcgtgactgt agatgaaatc gtagtggcca agaaaagtcc cacacatcag gagatctgga     1860

atcctgactc taagaagaca aagaaacacc cacctcctgt ggaaacaaaa aaaatccttg     1920

gattgaataa ctagtgatac cctcaataaa acagggattg ccaagaaggg aacaatcacc     1980

ccaaaaatga atgtttgcct ttattccgtg tttggtactt gattcacttt cttt           2034


<210> 1479
<211> 2900
<212> DNA
<213> Homo sapiens

<400> 1479
ggcagtcagg cctccccgct ctgtgctacc tgcggcccgg ctctcctccg cgcccccact       60

cgcgctgcga tgacgcgctc actgttcaag ggaaactttt ggagtgcaga catcctcagc      120

accatcggct atgacaacat tatccaacat ctgaacaatg gccgcaagaa ctgcaaagag      180

tttgaagact ttctaaaaga aagggcagca attgaagaga ggtatggcaa agatctgctc      240

aacctctcta ggaagaagcc gtgtggacag tctgaaatca acaccctgaa gcgggccctt      300

gaagtcttca agcagcaagt agacaatgtg gcacaatgtc acattcagct tgcacagagt      360

ttaagagaag aggccaggaa gatggaagaa ttcagggaaa agcaaaaact acaacgaaaa      420

aagacagagc tcataatgga tgctatccat aaacaaaaga gcttacaatt caagaaaacc      480

atggatgcaa agaagaacta tgagcagaaa tgccgggaca aagatgaggc agaacaggcc      540

gtcagccgga gtgccaacct ggtgaacccg aagcaacaag aaaagctttt tgtgaaactg      600

gcaacttcaa agaccgcagt agaggactca gacaaagcat acatgctgca catcggcacc      660

ctggataagg tccgagaaga gtggcagagt gagcacatca aggcctgcga ggcatttgag      720

gctcaagaat gtgaacgaat aaacttcttc cggaatgcat tgtggttaca tgtgaatcag      780

ctgtcacaac aatgtgtcac cagtgatgaa cacccatcat gtatgagaat ttctactcct      840

cccagaagaa tgcagtccca gcaggaaagg ctacagggcc taacttggca aggagaggac      900

ccctcccaat tcctaaaagc tcaccagatg atcccaatta ctctttggtt gatgactaca      960

gtttgctcta tcagtaaaat caatgaaacc agagcttttt ccggctagtg cttctgtgat     1020

atggaaaggg cacccagagc agcaggacct atagccacgt tatgtcagca atgaagactt     1080

tgaagtgaac ccttgctata attttttaga gatttaaaat ttatggtaga catttaggac     1140

aacataagca agtagagttc tgcagttttt tgaagtttac aaattgcccc attctgaaga     1200

attattcttt cccagttact caggttatga atgaattagg ttttcaacat gggaagcatg     1260

aaatccactt ctggatttgg agcatccact tgaggagcag aggtggcagc agaggattct     1320

gagccaccaa ctgcagtagt ggctcctttg gctttgggca gcctggctgt ggagtttcca     1380

cggcgacaca cagcctcagt ggtgcaagat ttaaaattac cttccttttt ggctggaaga     1440

cttagaagcc gcctgatcat actttctcat tttacagatg aggaaataaa gcctacaagt     1500

gtgaaattaa tttccttaca gttttcctag ctgatgaggg acagaaccag aactagagcc     1560

tgagcccaac ccacatcact attcttctaa cccttcctga agttgtgatg ctcatgctga     1620

aatttaagat gccaaatatt tttgccagca ctttttcagt tgggagaatc accagggttt     1680

aaatgtcaga tttattttta tgtggatccc tgtgtatgct gaactacaga gcatgatgtt     1740

taatctaatt taaggagcca ctgattgtaa aacatgccat tattttatgt tgcactaaga     1800

aggtggggtc gaggagttgc caataaactt gggacagact attgatggcc aagcccatct     1860

gaatttaaga tgctaaagta tgaaaaaaat acatcttaga atcaatgaaa taccatattt     1920

tgattccatt cctcaagata attttagagt tataaaacca gtcctcaatt ttgggtcttc     1980

acagagaatc tttcccttgc tagaccccag aattttaaat gcatccgtct tacactttca     2040

caaatatttg ggttttcctt tttcactcac aaacagcagg gaggtcatgt actttttgta     2100

caacacctgt gcactatgag aaaatggtac cttttagtta ttgacaagtt aaaatagcac     2160

tctcagtttt tcagtattac agagagcaaa tagtttcctc tcctgctctg tgcagtagct     2220

tttccagaac tatggacaaa ttgatcagaa gaagattgat tatttcctca tctttttttc     2280

ttttttttga gacagagtct ctctctgtcc cccaggctga agtgcagcgg catgatctca     2340

gctcactgca acctctgcct cccgggttca agtgattctc ctgcctcagc ctcctgagta     2400

gctgggatta caggcaccca ccaccacacc tggctaattt tttgtatttt tagtaaagac     2460

agggttttac catgttggtc aggctggtct caaactcctg acctcaggtg atccacctgc     2520

ctcggcctcc caaagtgctg ggattacagg cgtgagccac tgcgcccggc ctatttcccc     2580

acctttcgtg taaggtgcta ctgaacatga cagcttcttg tcatgacagg aaacttgcat     2640

cagttggata tccttttgag aaactgaatt ttgcaaaggg ccaaatttcc ccaaactgaa     2700

cgggctcagg aaatgttcct ttacactcag aacattctat tttaagtata ttatttattg     2760

ttggcagttc ctcagggatt tcccttttct ctgtattggt cagtgtagtt gatgtaaaac     2820

cgttttgtgg atggaaaata tttttatttt attgctcttt tagtttggta ggttaaataa     2880

aggttcttgg taatttggga                                                 2900


<210> 1480
<211> 4948
<212> DNA
<213> Homo sapiens

<400> 1480
taggcgccat tttcgagtga aggacccgga gccgaaacac cggtaggagc ggggaggtgg       60

gtactacaca accgtctcca gccttggtct gagtggactg tcctgcagcg accatgcccc      120

gtaaaggcac ccagccctcc actgcccggc gcagagagga agggccgccg ccgccgtccc      180

ctgacggcgc cagcagcgac gcggagcctg agccgccgtc cggccgcacg gagagcccag      240

ccaccgccgc agagactgca agtgaggaac ttgataatag aagtttagaa gagattttga      300

acagcattcc tcctcccccg cctccagcaa tgaccaatga agctggagct cctcggctta      360

tgataactca tattgtaaac cagaacttca aatcctatgc tggggagaaa attctgggac      420

ctttccataa gcgcttttcc tgtattatcg ggccaaatgg cagtggcaaa tccaatgtta      480

ttgattctat gctttttgtg tttggctatc gagcacaaaa aataagatct aaaaaactct      540

cagtattaat acataattct gatgaacaca aggacattca gagttgtaca gtagaagttc      600

attttcaaaa gataattgat aaggaagggg atgattatga agtcattcct aacagtaatt      660

tctatgtatc cagaacggcc tgcagagata atacttctgt ctatcacata agtggaaaga      720

aaaagacatt taaggatgtt ggaaatcttc ttcgaagcca tggaattgac ttggaccata      780

atagattttt aattttacag ggtgaagttg aacaaattgc tatgatgaaa ccaaaaggcc      840

agactgaaca cgatgagggt atgcttgaat atttagaaga tataattggt tgtggacggc      900

taaatgaacc tattaaagtc ttgtgtcgga gagttgaaat attaaatgaa cacagaggag      960

agaagttaaa cagggtaaag atggtggaaa aggaaaagga tgccttagaa ggagagaaaa     1020

acatagctat cgaatttctt accttggaaa atgaaatatt tagaaaaaag aatcatgttt     1080

gtcaatatta tatttatgag ttgcagaaac gaattgctga aatggaaact caaaaggaaa     1140

aaattcatga agataccaaa gaaattaatg agaagagcaa tatactatca aatgaaatga     1200

aagctaagaa taaagatgta aaagatacag aaaagaaact gaataaaatt acaaaattta     1260

ttgaggagaa taaagaaaaa tttacacagc tagatttgga agatgttcaa gttagagaaa     1320

agttaaaaca tgccacgagt aaagccaaaa aactggagaa acaacttcaa aaagataaag     1380

aaaaggttga agaatttaaa agtatacctg ccaagagtaa caatatcatt aatgaaacaa     1440

caaccagaaa caatgccctc gagaaggaaa aagagaaaga agaaaaaaaa ttaaaggaag     1500

ttatggatag ccttaaacag gaaacacaag ggcttcagaa agaaaaagaa agtcgagaga     1560

aagaacttat gggtttcagc aaatcggtaa atgaagcacg ttcaaagatg gatgtagccc     1620

agtcagaact tgatatctat ctcagtcgtc ataatactgc agtgtctcaa ttaactaagg     1680

ctaaggaagc tctaattgca gcttctgaga ctctcaaaga aaggaaagct gcaatcagag     1740

atatagaagg aaaactccct caaactgaac aagaattaaa ggagaaagaa aaagaacttc     1800

aaaaacttac acaagaagaa acaaacttta aaagtttggt tcatgatctc tttcaaaaag     1860

ttgaagaagc aaagagctca ttagcaatga atcgaagtag ggggaaagtc cttgatgcaa     1920

taattcaaga aaaaaaatct ggcaggattc caggaatata tggaagattg ggggacttag     1980

gagccattga tgaaaaatac gacgtggcta tatcatcctg ttgtcatgca ctggactaca     2040

ttgttgttga ttctattgat atagcccaag aatgtgtaaa cttccttaaa agacaaaata     2100

ttggagttgc aacctttata ggtttagata agatggctgt atgggcgaaa aagatgaccg     2160

aaattcaaac tcctgaaaat actcctcgtt tatttgattt agtaaaagta aaagatgaga     2220

aaattcgcca agctttttat tttgctttac gagatacctt agtagctgac aacttggatc     2280

aagccacaag agtagcatat caaaaagata gaagatggag agtggtaact ttacagggac     2340

aaatcataga acagtcaggt acaatgactg gtggtggaag caaagtaatg aaaggaagaa     2400

tgggttcctc acttgttatt gaaatctctg aagaagaggt aaacaaaatg gaatcacagt     2460

tgcaaaacga ctctaaaaaa gcaatgcaaa tccaagaaca gaaagtacaa cttgaagaaa     2520

gagtagttaa gttacggcat agtgaacgag aaatgaggaa cacactagaa aaatttactg     2580

caagcatcca gcgtttaata gagcaagaag aatatttgaa tgtccaagtt aaggaacttg     2640

aagctaatgt acttgctaca gcccctgaca aaaaaaagca gaaattgcta gaagaaaacg     2700

ttagtgcttt caaaacagaa tatgatgctg tggctgagaa agctggtaaa gtagaagctg     2760

aggttaaacg cttacacaat accatcgtag aaatcaataa tcataaactc aaggcccaac     2820

aagacaaact tgataaaata aataagcaat tagatgaatg tgcttctgct attactaaag     2880

cccaagtagc aatcaagact gctgacagaa accttcaaaa ggcacaagac tctgtcttgc     2940

gtacagagaa agaaataaaa gatactgaga aagaggtgga tgacctaaca gcagagctga     3000

aaagtcttga ggacaaagca gcagaggtcg taaagaatac aaatgctgca gagatttcaa     3060

aaatatcact gcatcctata gaagataatc ctattgaaga gatttcggtt ctaagcccag     3120

aggatcttga agcgatcaag aatccagatt ctataacaaa tcaaattgca cttttggaag     3180

cccggtgtca tgaaatgaaa ccaaacctcg gtgccatcgc agagtataaa aagaaggaag     3240

aattgtattt gcaacgggta gcagaattgg acaaaattac ttatgaaaga gacagtttta     3300

gacaggcata tgaagatctt cggaaacaaa ggcttaatga atttatggca ggtttttata     3360

taataacaaa taaattaaag gaaaattacc aaatgcttac tttgggaggg gacgccgaac     3420

tcgagcttgt agacagcttg gatcctttct ctgaaggaat catgttcagt gttcgaccac     3480

ctaagaaaag ttggaaaaag atcttcaacc tttcgggagg agagaaaaca cttagttcat     3540

tggctttagt atttgctctt caccactaca agcccactcc cctttacttc atggatgaga     3600

ttgatgcagc ccttgatttt aaaaatgtgt ccattgttgc attttatata tatgaacaaa     3660

caaaaaatgc acagttcata ataatttctc ttcgaaataa tatgtttgag atttcggata     3720

gacttattgg aatttacaag acatacaaca taacaaaaag tgttgctgta aatccaaaag     3780

aaattgcatc taagggactt tgttgaactt tatgctgaag attcttcaag ttgattcagt     3840

gtattactga tttttttcta tttgtaaagg attatgagtt gtataaaata catactccct     3900

aaactagatc atgaaactgg tttctgtttt atgcagttgt catttgtaaa gtctaataaa     3960

atattctcta taattgcttc tagattacaa aaatatgaca atcttgtaag tagcagacta     4020

tggagaaaaa tgagttacct ggagggtcag gtaacttgcc aaactaaaaa gtatgttagt     4080

tgaggcaaag tcctaagcaa ggttgtgcta tcaaggctca gcataccttc gtgggccttt     4140

gatttaccaa cactggaaat gcctgccaac taatcttgga tagattcttt aaggcattcc     4200

acttagcttg ccagttgaga caatcaccac agttattacc caaatactat gaacatattt     4260

ttgtaaacca gtcattctga attatagtga tgagaattta aatatatgct tttctagaat     4320

ttgatgtttg accatttatg acttaattac cagagagcca gtaaattagg acagtgtttc     4380

aacaagccta ggctatctcg taagttgaaa aatatcccac tatagttgct tcatgagtat     4440

gaagtaagat ggcctctgat ttacactggt tcaatttaca aattttcaac tttatgatag     4500

gtttatccgg gtactaaatg catttcaact tgatagtttc aacttatgat aggtttacca     4560

ggatgtagtc ccactgttga ggagcatcta tttaggggtt aattacttta gtaataagtg     4620

gaaagtaaga taccttgagt aatgtttgcc tataaaattg tcagcgtatt tttacactat     4680

tggctcaaga atgttataat gctaagggac ataagttggc aaccacttgg tttttggaag     4740

gactttcggt attgtattag aagtctgccc tagctgttaa atttctgggt atttatccta     4800

aggaattaat taaagagtta attgttcctt tcttcagtgg gccattgttt tagatattta     4860

aaaaatccaa cagtttctat cataatgtaa ctgtaaaaat gtaaacacat tattagcatg     4920

gacttttaaa taaagattta aagaaagc                                        4948


<210> 1481
<211> 3177
<212> DNA
<213> Homo sapiens

<400> 1481
ggcaccgcgg cgctcgggtg tttttggggg cccgggtgga gggcccgggt gccggggccc       60

aaggtgcggc ctcgctagcg ggagagggag cgggatcacc ggcccggaga gagctctcag      120

ggccagagcg gggcaggagg atgctttccc agccccacca tggagctgcg ctgtggggga      180

ttgctgttca gttctcgctt tgattcaggg aatctagccc acgtggagaa ggtggaatct      240

ttgtccagtg atggggaagg ggtaggaggt ggggcgtcag ccctgaccag tggcattgcc      300

tcttcccctg actatgaatt caacgtgtgg acccgaccag actgtgctga aacggaattt      360

gagaatggga acaggtcatg gttctacttc agcgtccggg gaggaatgcc aggaaaactc      420

atcaagatca acattatgaa catgaacaag cagagcaagc tgtattccca gggcatggcc      480

ccctttgtgc gcacactgcc cacccggcca cgctgggaac gcattcgaga ccggcccacc      540

tttgagatga cagagacgca gtttgtgtta tcctttgttc atcgtttcgt ggagggccgt      600

ggggccacca ccttcttcgc cttctgctac cccttctcct acagtgactg ccaggaactg      660

ctaaaccagc tagaccagcg ctttccggag aaccacccta cccatagcag ccccctggat      720

accatctatt accatcggga gctcctttgc tattctctgg atggacttcg tgtagatctg      780

ctgacgatca cttcctgcca tgggcttcga gaagatcgag agccccgtct agagcagcta      840

tttcctgata ccagcacccc tcgaccattc cgtttcgcag gcaagaggat attcttctta      900

agcagtagag tacacccagg ggagactcca tctagctttg tcttcaatgg ctttctggac      960

ttcatcctcc gacctgatga tccccgggcc caaaccctcc gtcgcctctt cgtctttaag     1020

ctgattccca tgttgaaccc cgatggtgtg gtccggggac actaccgcac agactcacgt     1080

ggagtgaatc tgaaccgtca gtacctgaag cctgatgccg tcctgcaccc ggccatctat     1140

ggggccaaag ctgtgcttct ctaccaccat gtgcactctc gtctgaactc ccagagttcc     1200

tctgagcacc agcccagttc ctgtctccct cctgatgctc ctgtttctga cctggagaaa     1260

gccaacaatc tccaaaatga agctcagtgt gggcactcag ctgacaggca taacgctgaa     1320

gcctggaaac aaacagagcc agcagaacag aagctcaaca gtgtgtggat tatgccacaa     1380

cagtctgcgg ggcttgaaga gtcagcccct gataccatcc cccccaaaga gagtggcgtt     1440

gcttactatg tggacctgca tggacatgct tccaaaaggg gctgcttcat gtacggaaac     1500

agctttagtg atgagagcac ccaggtggaa aacatgctat atccaaagct catctccttg     1560

aattcagccc acttcgactt ccagggctgc aatttctcag agaagaatat gtatgcccga     1620

gaccgtagag atggccagtc taaagaggga agcggccgtg ttgcaatcta caaagcctca     1680

gggataatcc acagctacac acttgaatgc aactacaaca ctggacgctc agtaaacagc     1740

atccctgctg cctgccatga caatgggcgt gccagccccc ctcccccgcc ggctttcccc     1800

tccagataca ctgtggaact atttgagcag gtgggacgag ctatggccat tgcagccctg     1860

gacatggcgg aatgtaatcc gtggccccga attgtactgt cagagcacag cagccttact     1920

aatctacggg cctggatgct gaaacatgta cgcaacagcc gaggcctaag cagcactctg     1980

aatgtgggtg tcaacaagaa gaggggcctt cgaactccac ccaaaagtca caatgggttg     2040

cctgtctcct gctccgaaaa caccttgagt cgggcacgaa gttttagcac cggcacaagt     2100

gccggtggta gcagcagcag ccaacaaaat tctccacaga tgaagaattc ccccagcttt     2160

ccttttcatg gcagtcggcc tgcagggctg ccaggcctgg gctctagtac ccaaaaggtc     2220

acccaccggg tgctgggccc cgtcagagag ccccgaagcc aggacaggag acggcagcag     2280

cagcccctga accatcgtcc tgcaggcagc ctcgctccat ccccagctcc tactagttct     2340

ggcccagcct cctcacacaa gctgggctcc tgtctactgc ctgattcatt caacatacca     2400

gggagcagtt gctcactctt gtcctctgga gacaaaccag aggctgtcat ggtaatcggg     2460

aaaggtctgc tagggactgg agctcggatg ccctgcatca agactcgatt gcaggctagg     2520

cccaggttgg gccggggctc accgccgact cgcagaggga tgaaaggctc ttcaggcccc     2580

acatccccta ccccccggac cagggagagc agtgagctgg agctgggatc ctgctctgct     2640

acaccagggc tgcctcaggc caggccccca cggccccgct ctgcccctgc cttttctcct     2700

atatcctgta gtctatctga ctccccatcc tggaattgtt acagcagggg tcccttgggc     2760

caacctgagg tttgttttgt ccctaaatct cccccactga ctgtttctcc ccgggtctga     2820

taatgccttt atgttcaagc ccaggatata gccccaagat ggggtaacag tgggaaatat     2880

gctagttccc ctccaggccg ctgattccat gtgacagccg ttaagtcctt ggaatgccag     2940

ccacgctgtc caaggcatta cagagtatca ccttgagaca gaacaaaaca gggacctgcc     3000

accccttccc tccctccgca gcacaagatt ttgggaccac aaaaaaaagt ctatattttt     3060

atattggggg gagggagtag aaaagcaagc ccctatactg ggccctattc agtggcagct     3120

tcttgttcca taggattaag gaagactctg aggaaataaa agttgtttgg aaaaatc        3177


<210> 1482
<211> 5559
<212> DNA
<213> Homo sapiens

<400> 1482
gcgggactca agagtagcct tcctcgagga cctgcctttc ccatttgctg cctgaagtta       60

atgtttcttg ctggccaaat cagggacatg ccggcattag cgggatgagt gggtgttccg      120

gcagggatgt ggtcattgac ggccagtgag ggcgagagta ccacggccca cttcttcctt      180

ggagctggag atgaggggct gggcacccgt ggaataggca tgaggccaga agagagtgac      240

agcgagctcc ttgaggatga ggaggatgaa gtgcctcctg aacctcagat cattgttggc      300

atctgtgcca tgaccaagaa atccaagtcc aagccaatga ctcaaatcct agagcgactc      360

tgcagatttg actacctgac tgttgtcatt ctgggagaag atgtaatcct taatgaacct      420

gtggaaaact ggccatcctg ccactgcctc atctctttcc actccaaagg ctttcctctg      480

gacaaagctg ttgcttactc caagcttcga aacccctttc ttatcaatga tctggccatg      540

cagtattaca tccaagatag gagggaggtg taccggatcc tgcaggaaga gggtattgat      600

ctgcctcgat atgctgtgct caaccgtgat cctgcccggc ctgaggaatg caacctgata      660

gaaggtgaag accaagtaga ggtcaatgga gctgtctttc ccaagccctt tgtggagaag      720

ccagtgagtg cagaagacca caatgtttac atctactacc ccagctcagc tggaggagga      780

agccagcgtc tctttcgtaa gattggcagc cgaagcagtg tttactctcc tgagagcagc      840

gtccgaaaga cggggtcgta catctatgag gagtttatgc caacagatgg cacagatgtc      900

aaggtgtata cagtggggcc agattatgcc catgctgaag ctagaaaatc tccagctttg      960

gatgggaagg ttgaacgaga cagtgagggg aaagagattc gatatccagt catgctgact     1020

gccatggaaa agctggtggc caggaaagtc tgcgtagctt tcaagcaaac agtttgtgga     1080

tttgaccttc ttcgtgccaa tggtcattcc tttgtgtgtg atgtcaatgg ctttagtttt     1140

gtcaagaact cgatgaaata ctacgatgac tgtgccaaga ttctggggaa caccataatg     1200

cgggagcttg ccccacagtt ccagattcca tggtccatcc ccacggaggc tgaggacatt     1260

cccattgttc ccaccacatc tggcactatg atggaacttc gttgtgtcat tgcaattatt     1320

cgtcatgggg atcgtactcc caagcagaag atgaagatgg aagtgaaaca cccaaggttt     1380

tttgctctgt ttgaaaaaca tggtggctac aagacaggga aattaaaact caagcgacct     1440

gagcagctcc aggaggtgct ggatatcaca aggctgttgt tggctgaact ggagaaagaa     1500

ccaggtggtg agatcgagga gaagactgga aaactagagc agctgaagtc tgtactggag     1560

atgtatggtc acttctcagg tataaaccgg aaggtacaat tgacttacta ccctcatgga     1620

gtaaaagctt ctaatgaggg gcaagatcca cagagggaaa ctctggcccc atctctgttg     1680

ctggtactga agtggggtgg agaactgact cctgctggcc gtgttcaggc tgaggagctg     1740

gggcgagctt ttcgctgcat gtaccctgga ggacagggtg actatgctgg cttccctggt     1800

tgtgggctgc ttcgtctcca tagcactttc cgccacgatc tcaagatcta tgcctctgat     1860

gagggtcgtg ttcagatgac tgctgctgcc ttcgccaagg gccttctggc tctagaaggg     1920

gagctgacac ccattttggt gcaaatggtg aagagtgcca acatgaatgg gctactggac     1980

agcgatgggg attccttgag cagctgccag caccgggtga aggctcggct gcaccatatt     2040

ctacagcagg atgcgccctt tggccctgag gactacgatc agctggctcc caccagaagt     2100

acttccctgc tcaactccat gactatcatc cagaatcctg tgaaggtctg tgatcaggta     2160

tttgccctga tcgaaaacct cacccaccag atccgggaac gaatgcagga ccccaggtct     2220

gtagacctgc agctctacca cagtgagaca ctagagctaa tgctacagcg ttggagcaag     2280

ctggagcgtg actttcgaca gaagagtggg cgctatgata tcagtaagat ccctgacatc     2340

tatgactgtg tcaagtatga tgtgcagcac aatgggagtc tgggacttca aggcacagca     2400

gagttgctcc gtctctctaa ggcactggct gatgtggtca ttccccagga gtacgggatc     2460

agtcgggagg agaaactgga aattgctgtg ggcttctgtc ttccactgtt gcggaagata     2520

ctacttgacc tgcagagaac ccacgaggat gagtctgtca acaagctgca tcccctgtac     2580

tcccgaggcg tgctctcccc aggtcgccac gttcgaacgc gtctctattt caccagtgag     2640

agccatgtcc actccctgct cagtgtcttc cgttatggag gacttcttga tgagacccag     2700

gatgcacaat ggcagcgagc tttggattat cttagtgcca tctcagagct taactacatg     2760

acccagattg tcatcatgct ttatgaggac aacacacagg atcccttatc agaggaacgg     2820

ttccatgtgg agctacactt cagccccgga gtgaaaggtg ttgaggaaga aggcagtgcc     2880

ccggctggct gtggattccg tccagcctct tctgagaatg aggagatgaa aaccaaccaa     2940

ggcagtatgg agaacctgtg tccaggaaag gcatcagatg aaccagaccg ggcattgcag     3000

acttcacccc agcctcctga gggccctggc cttccgagga gatcacccct cattcgtaac     3060

cgaaaagctg gttccatgga ggtactttct gagacttcat cctcgaggcc tggtggctac     3120

cggctctttt catcttcacg gccacccaca gaaatgaagc agagtggcct agggtttgaa     3180

gggtgttcca tggtgcctac catctaccct ctggaaacac tgcataatgc cctttcccta     3240

cgtcaagtga gtgaattctt gagtagagtc tgccagcgcc acactgatgc ccaggcacag     3300

gcatctgcag ccctctttga ttccatgcac agcagccagg cctcagataa cccattttct     3360

ccaccacgta ctcttcattc acctcccctg caactccagc agcgctctga gaagccccct     3420

tggttagaga caaggttttg ccatgttggc caggctggtt tagagctcct gacctcaagt     3480

gatctgcctg cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcacccag     3540

ccagacagca gtggcccttc tagcactgtg tccagtgctg gtccttcttc ccctactaca     3600

gtagatggta actcccaatt tggcttcagt gatcaaccct ccctaaattc acacgtggct     3660

gaagaacatc aaggccttgg gctgctccag gagacccctg ggagtggagc acaagagctc     3720

tccatagaag gggagcaaga gctttttgaa ccaaatcagt ccccacaggt gccacctatg     3780

gaaaccagcc agccatacga ggaggtcagc cagccatgtc aggaggtccc tgacatcagc     3840

cagccatgcc aggacatttc tgaggcgctc agccagccat gtcagaaggt ccctgacatc     3900

agccagcaat gccaggagaa ccatgacaat ggtaaccaca catgccagga ggtccctcac     3960

atcagccagc catgccagaa gtccagccaa ctgtgccaga aagtctctga ggaagtttgc     4020

cagctatgtc tggagaactc cgaggaggtc agccagccat gccagggggt ctctgtggag     4080

gttggcaagc tggtccataa gttccatgta ggggttggta gcttggtcca ggaaaccctt     4140

gtagaagttg gcagcccagc tgaagagatc cctgaggagg tcatccagcc ataccaggag     4200

ttctctgtgg aggttggcag gctggcccag gagacttctg cgatcaatct gttatctcag     4260

ggcatccctg agattgataa accatcccaa gagttccctg aggagattga tctgcaggcc     4320

caggaggtcc ctgaggagat aaattagaag tcctgggtgg tccctgaagt gattgatcag     4380

ctgcctggag agggtattcc tcaagcccag catccatctg gtgatccaaa ccctcagagc     4440

cagtctctag cccatgacca gcactcaccc cttccaccag caacatgtga ttaattttct     4500

cattagtggt atcacactat accagccatt tgagccagca accttttctg ttggctaact     4560

cactggccag ctctcaccag cggtgtctgg ggaagtagtt ctctttgtat gaagcatacc     4620

tgtgccagag ctgtggttga ggaggagcca gttttaggtt cgaagaagcc attggctcct     4680

cacttagcca ttagacttga ataggatttc cttggggtgg gttggtctgt cattacccag     4740

ccttctctga gcatcctagg aaatcacaga ttgttaaagg aaatgccgct tcactgctga     4800

agacaccatc tggcgacagc aaatgcaaaa gaggggactc tagggtcttc acttttctgg     4860

ggaaatgttc acgacttctc aaggtacgct tagaccatat gtgcattcag gggactcttg     4920

tctttgccag cactcctcag gtgagcccgg gatggctatc tgaaatgtct ggaaaataga     4980

gtcccttccc caaacatctg acatggccac taaatcttta gacttgcctt atagatcctt     5040

ccatatcatc cccaagtgcc ccttctgcct cagtcctgtt cctctgggca atagctctag     5100

ggaaaagtag gtattagact gctgtgcaaa attcagagca actacttaaa atgctctaga     5160

ggattcttag ccagtctgtg aaagtgggcc tcctctgtgg tggggctgtt tggcttagga     5220

gatgctgtag tagtagagat aatcaggttc tattttaagc aatcagcaga gatcaatatt     5280

gtacagatac aagcaaaggt ttaataaata tatatatata tatttatttc tgtagttgtg     5340

ccagggacag actggccaaa gaccaaacac tgcagggtcc ccaagaaatt tgtccttata     5400

tcattgtgtc tgagggccag atatgattat gaagcttttt ccaaagatcc agggatggga     5460

atgggagtgg gtaggagggg taatgcggtc attggagtcg ggggctggaa cattatgagt     5520

gctcaataaa tataaactaa tgagaatggt ggtgatgga                            5559


<210> 1483
<211> 1757
<212> DNA
<213> Homo sapiens

<400> 1483
aacccgtttc catggctgcg agaactgacg ctccccaacc gtcccgcaac tgtcctgtcc       60

cagactttgg caccgtcggg gtccgtcgtc cccgaatgtg acagcatccc caccccggct      120

gctgcccagg atccgccgga ccccggcctc gatatgggag acctggaact gctgctgccc      180

ggggaagctg aagtgctggt gcggggtctg cgcagcttcc cgctacgcga gatgggctcc      240

gaagggtgga accagcagca tgagaacctg gagaagctga acatgcaagc catcctcgat      300

gccacagtca gccagggcga gcccattcag gagctgctgg tcacccatgg gaaggtccca      360

acactggtgg aggagctgat cgcagtggag atgtggaagc agaaggtgtt ccctgtgttc      420

tgcagggtgg aggacttcaa gccccagaac accttcccca tctacatggt ggtgcaccac      480

gaggcctcca tcatcaacct cttggagaca gtgttcttcc acaaggaggt gtgtgagtca      540

gcagaagaca ctgtcttgga cttggtagac tattgccacc gcaaactgac cctgctggtg      600

gcccagagtg gctgtggtgg cccccctgag ggggagggat cccaggacag caaccccatg      660

caggagctgc agaagcaggc agagctgatg gaatttgaga ttgcactgaa ggccctctca      720

gtactacgct acatcacaga ctgtgtggac aggcagtggt cagtctccca gcccccacag      780

ctggctcact tgaagagaat tcaacgtctg cacccagtgt gctggttcct ctccccaggc      840

aagctgcagc agttcgaggg cagccgttgg catactgtgg ccccctcaga gcagcaaaag      900

ctgagcaagt tggacgggca agtgtggatc gccctgtaca acctgctgct aagccctgag      960

gctcaggcgc gctactgcct cacaagtttt gccaagggac ggctactcaa gcttcgggcc     1020

ttcctcacag acacactgct ggaccagctg cccaacctgg cccacttgca gagtttcctg     1080

gcccatctga ccctaactga aacccagcct cctaagaagg acctggtgtt ggaacagatc     1140

ccagaaatct gggagcggct ggagcgagaa aacagaggca agtggcaggc aattgccaag     1200

caccagctcc agcatgtgtt cagcccctca gagcaggacc tgcggctgca ggcgcgaagg     1260

tgggctgaga cctacaggct ggatgtgcta gaggcagtgg ctccagagcg gccccgctgt     1320

gcttactgca gtgcagaggc ttctaagcgc tgctcacgat gccagaatga gtggtattgc     1380

tgcagggagt gccaagtcaa gcactgggaa aagcatggaa agacttgtgt cctggcagcc     1440

cagggtgaca gagccaaatg agggctgcag ttgctgaggg ccgaccaccc atgccaaggg     1500

aatccaccca gaatgcaccc ctgaacctca agatcacggt ccagcctctg ccggagcccc     1560

agtctccgca gtggagagca gagcgggcgg taaagctgct gaccgatctc cctcctcctc     1620

accccaagtg aaggctcgag acttcctgcc ccacccagtg ggtaggccaa gtgtgttgct     1680

tcagcaaacc ggaccaggag ggccagggcc ggatgtgggg accctcttcc tctagcacag     1740

taaagctggc ctccaga                                                    1757


<210> 1484
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 1484
atgaatgaag ctatggctac agattcccca agaagaccca gtcgttgtac tggtggagtt       60

gtggttcgcc cccaggctgt cacagagcag tcctacatgg aaagtgttgt gacttttctg      120

caggatgttg tgccacaggt atattgttgt ggagacaaca ttcagtctta tactgccaca      180

gtcattagtg ctgctaaaac attgaaaagt ggcctgacaa tggtagggaa agtggtgact      240

cagctgacag gcacactgcc ttcaggtgtg acagaagatg atgttgccat ccacagtaat      300

tcacggcgga gtcctttggt cccaggcatc atcacagtta ttgacaccga aaccgttgga      360

gagggccagg tgcttgtgag tgaggattct gacagtgatg gcattgtggc ccacttccct      420

gcccatgaga agccagtgtg ctgcatggct tttaatacaa gtggaatgct tctagtcaca      480

acagacaccc ttggccatga ctttcatgtc ttccaaattc tgactcatcc ttggtcctca      540

tcacaatgtg ctgtccacca tctgtatact cttcacaggg gagaaactga agccaaagta      600

caggacatct gcttcagcca tgactgtcgc tgggttgtgg tcagtactct ccggggtact      660

tcccacgttt tccccatcaa cccttatggt ggccagcctt gtgttcgtac acatatgtca      720

ccacgagtag tgaatcgcat gagccgtttc cagaaaagtg ctggactgga agagattgaa      780

caagaactga cgtctaagca aggaggtcgc tgtagccctg ttccaggtct atcaagcagc      840

ccttctgggt cacccttgca tgggaaactg aacagccaag actcctataa caattttacc      900

aacaacaacc ctggcaaccc tcggctctct cctcttccca gcttgatggt agtgatgcct      960

cttgcacaaa tcaagcagcc aatgacattg gggaccatca ccaaacgaac cggcaaagtt     1020

aaacctcctc cacaaatttc acccagcaaa tcgatgggcg gagaattttg tgtggctgct     1080

atcttcggaa catccaggtc atggtttgca aataatgcag gtctgaaaag agaaaaagat     1140

cagtccaaac aagttgtagt tgagtccctg tacattatca gttgctatgg caccttagtg     1200

gaacacatga tggagccgca acccctcaat ggaatgaatt gcagccaccg tttaatgcaa     1260

accaccctct gctcctcgct gcagatgcag tacagtatta tcagttcctg cttgctggcc     1320

tggttccccc tggaagtcct gggcccatta ctcgacatgg gtcttacgac agtttag        1377


<210> 1485
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 1485
gagagactac aactcccagt atgcaccgcg atgcgcgcct caccctgcat ctcccagccc       60

gcagccagct ggcatcctag accctctgcc ctgcgaccaa cagccgggag cggaccagac      120

accagaactc ccggaacggt tgaagacggt tccgctccct gtcccgcctt tcgcagccca      180

gcagtttcgc cctgcggaga ggagccttgc tgtttccaaa tctctcctgc tgaagagaca      240

ttggagctag ggcggctagt ttcacctggc tgtcacaaat cctctgcacc ccaggagcgc      300

cgcttggacc cccgggctcg ctgcgtggtc catatctagg tcgggcctct cacggagact      360

ttcccaccag tgtaataaag aggagaaaac gtcacagcgg aagggcctga ccctgctgca      420

tccactaagg aaacagctac ggggatggga ccctgggagc tgctgtggag cctcatccac      480

cgcttctctg accccaccca ggctgcttcc caggcctcag ggtcttagtg tggacctccg      540

ggccgtgatt aatgcaggtc agcaggacca gagcgcccct tggtccctcc caacacatga      600

gggtagtttg tgtggtgagg tcagggatag tgtctgcgct tctaccctga atagggctcc      660

cttggaaaat actttaatat ctctttttaa ataccccctt ggaccacttt taatagtttt      720

ctgatagaac taaacagtga tcattctctt aattcatgtt tccattaagt ttttcaggtt      780

aagtactgca cgactactcg cttctgaaac tgatagacac tgcctcagct ccgtgcaggg      840

cagacgcaca agagcagaat ctccgtggga catctctctg gagcatcaat attactgcag      900

tatttggaag aaacaaattt aaataagttc taaggtgaag aatggaacat ttaagacaag      960

tctggaaagt catctgcctt taataactgt cgtttgtcct taacgtcaga ctttctccaa     1020

gaccaaaact ctaagaactt atttccattc ttacaaatag taaaaatgat aaatcatatc     1080

aagtcaattg aaagtcctgc ctgctgcttt cctaaa                               1116


<210> 1486
<211> 5565
<212> DNA
<213> Homo sapiens

<400> 1486
gcgggactca agagtagcct tcctcgagga cctgcctttc ccatttgctg cctgaagtta       60

atgtttcttg ctggccaaat cagggacatg ccggcattag cgggatgagt gggtgttccg      120

gcagggatgt ggtcattgac ggccagtgag ggcgagagta ccacggccca cttcttcctt      180

ggagctggag atgaggggct gggcacccgt ggaataggca tgaggccaga agagagtgac      240

agcgagctcc ttgaggatga ggaggatgaa gtgcctcctg aacctcagat cattgttggc      300

atctgtgcca tgaccaagaa atccaagtcc aagccaatga ctcaaatcct agagcgactc      360

tgcagatttg actacctgac tgttgtcatt ctgggagaag atgtaatcct taatgaacct      420

gtggaaaact ggccatcctg ccactgcctc atctctttcc actccaaagg ctttcctctg      480

gacaaagctg ttgcttactc caagcttcga aacccctttc ttatcaatga tctggccatg      540

cagtattaca tccaagatag gagggaggtg taccggatcc tgcaggaaga gggtattgat      600

ctgcctcgat atgctgtgct caaccgtgat cctgcccggc ctgaggaatg caacctgata      660

gaaggtgaag accaagtaga ggtcaatgga gctgtctttc ccaagccctt tgtggagaag      720

ccagtgagtg cagaagacca caatgtttac atctactacc ccagctcagc tggaggagga      780

agccagcgtc tctttcgtaa gattggcagc cgaagcagtg tttactctcc tgagagcagc      840

gtccgaaaga cggggtcgta catctatgag gagtttatgc caacagatgg cacagatgtc      900

aaggtgtata cagtggggcc agattatgcc catgctgaag ctagaaaatc tccagctttg      960

gatgggaagg ttgaacgaga cagtgagggg aaagagattc gatatccagt catgctgact     1020

gccatggaaa agctggtggc caggaaagtc tgcgtagctt tcaagcaaac agtttgtgga     1080

tttgaccttc ttcgtgccaa tggtcattcc tttgtgtgtg atgtcaatgg ctttagtttt     1140

gtcaagaact cgatgaaata ctacgatgac tgtgccaaga ttctggggaa caccataatg     1200

cgggagcttg ccccacagtt ccagattcca tggtccatcc ccacggaggc tgaggacatt     1260

cccattgttc ccaccacatc tggcactatg atggaacttc gttgtgtcat tgcaattatt     1320

cgtcatgggg atcgtactcc caagcagaag atgaagatgg aagtgaaaca cccaaggttt     1380

tttgctctgt ttgaaaaaca tggtggctac aagacaggga aattaaaact caagcgacct     1440

gagcagctcc aggaggtgct ggatatcaca aggctgttgt tggctgaact ggagaaagaa     1500

ccaggtggtg agatcgagga gaagactgga aaactagagc agctgaagtc tgtactggag     1560

atgtatggtc acttctcagg tataaaccgg aaggtacaat tgacttacta ccctcatgga     1620

gtaaaagctt ctaatgaggg gcaagatcca cagagggaaa ctctggcccc atctctgttg     1680

ctggtactga agtggggtgg agaactgact cctgctggcc gtgttcaggc tgaggagctg     1740

gggcgagctt ttcgctgcat gtaccctgga ggacagggtg actatgctgg cttccctggt     1800

tgtgggctgc ttcgtctcca tagcactttc cgccacgatc tcaagatcta tgcctctgat     1860

gagggtcgtg ttcagatgac tgctgctgcc ttcgccaagg gccttctggc tctagaaggg     1920

gagctgacac ccattttggt gcaaatggtg aagagtgcca acatgaatgg gctactggac     1980

agcgatgggg attccttgag cagctgccag caccgggtga aggctcggct gcaccatatt     2040

ctacagcagg atgcgccctt tggccctgag gactacgatc agctggctcc caccagaagt     2100

acttccctgc tcaactccat gactatcatc cagaatcctg tgaaggtctg tgatcaggta     2160

tttgccctga tcgaaaacct cacccaccag atccgggaac gaatgcagga ccccaggtct     2220

gtagacctgc agctctacca cagtgagaca ctagagctaa tgctacagcg ttggagcaag     2280

ctggagcgtg actttcgaca gaagagtggg cgctatgata tcagtaagat ccctgacatc     2340

tatgactgtg tcaagtatga tgtgcagcac aatgggagtc tgggacttca aggcacagca     2400

gagttgctcc gtctctctaa ggcactggct gatgtggtca ttccccagga gtacgggatc     2460

agtcgggagg agaaactgga aattgctgtg ggcttctgtc ttccactgtt gcggaagata     2520

ctacttgacc tgcagagaac ccacgaggat gagtctgtca acaagctgca tcccctgtac     2580

tcccgaggcg tgctctcccc aggtcgccac gttcgaacgc gtctctattt caccagtgag     2640

agccatgtcc actccctgct cagtgtcttc cgttatggag gacttcttga tgagacccag     2700

gatgcacaat ggcagcgagc tttggattat cttagtgcca tctcagagct taactacatg     2760

acccagattg tcatcatgct ttatgaggac aacacacagg atcccttatc agaggaacgg     2820

ttccatgtgg agctacactt cagccccgga gtgaaaggtg ttgaggaaga aggcagtgcc     2880

ccggctggct gtggattccg tccagcctct tctgagaatg aggagatgaa aaccaaccaa     2940

ggcagtatgg agaacctgtg tccaggaaag gcatcagatg aaccagaccg ggcattgcag     3000

acttcacccc agcctcctga gggccctggc cttccgagga gatcacccct cattcgtaac     3060

cgaaaagctg gttccatgga ggtactttct gagacttcat cctcgaggcc tggtggctac     3120

cggctctttt catcttcacg gccacccaca gaaatgaagc agagtggcct aggctcacag     3180

tgcacagggc tgttcagcac cacagtgctg ggtggctcct ccagtgcccc gaatcttcag     3240

gactacgccc gcagccatgg caaaaagcta ccacctgcca gtctgaagca ccgagatggg     3300

tttgaagggt gttccatggt gcctaccatc taccctctgg aaacactgca taatgccctt     3360

tccctacgtc aagtgagtga attcttgagt agagtctgcc agcgccacac tgatgcccag     3420

gcacaggcat ctgcagccct ctttgattcc atgcacagca gccaggcctc agataaccca     3480

ttttctccac cacgtactct tcattcacct cccctgcaac tccagcagcg ctctgagaag     3540

cccccttggt acagcagtgg cccttctagc actgtgtcca gtgctggtcc ttcttcccct     3600

actacagtag atggtaactc ccaatttggc ttcagtgatc aaccctccct aaattcacac     3660

gtggctgaag aacatcaagg ccttgggctg ctccaggaga cccctgggag tggagcacaa     3720

gagctctcca tagaagggga gcaagagctt tttgaaccaa atcagtcccc acaggtgcca     3780

cctatggaaa ccagccagcc atacgaggag gtcagccagc catgtcagga ggtccctgac     3840

atcagccagc catgccagga catttctgag gcgctcagcc agccatgtca gaaggtccct     3900

gacatcagcc agcaatgcca ggagaaccat gacaatggta accacacatg ccaggaggtc     3960

cctcacatca gccagccatg ccagaagtcc agccaactgt gccagaaagt ctctgaggaa     4020

gtttgccagc tatgtctgga gaactccgag gaggtcagcc agccatgcca gggggtctct     4080

gtggaggttg gcaagctggt ccataagttc catgtagggg ttggtagctt ggtccaggaa     4140

acccttgtag aagttggcag cccagctgaa gagatccctg aggaggtcat ccagccatac     4200

caggagttct ctgtggaggt tggcaggctg gcccaggaga cttctgcgat caatctgtta     4260

tctcagggca tccctgagat tgataaacca tcccaagagt tccctgagga gattgatctg     4320

caggcccagg aggtccctga ggagataaat tagaagtcct gggtggtccc tgaagtgatt     4380

gatcagctgc ctggagaggg tattcctcaa gcccagcatc catctggtga tccaaaccct     4440

cagagccagt ctctagccca tgaccagcac tcaccccttc caccagcaac atgtgattaa     4500

ttttctcatt agtggtatca cactatacca gccatttgag ccagcaacct tttctgttgg     4560

ctaactcact ggccagctct caccagcggt gtctggggaa gtagttctct ttgtatgaag     4620

catacctgtg ccagagctgt ggttgaggag gagccagttt taggttcgaa gaagccattg     4680

gctcctcact tagccattag acttgaatag gatttccttg gggtgggttg gtctgtcatt     4740

acccagcctt ctctgagcat cctaggaaat cacagattgt taaaggaaat gccgcttcac     4800

tgctgaagac accatctggc gacagcaaat gcaaaagagg ggactctagg gtcttcactt     4860

ttctggggaa atgttcacga cttctcaagg tacgcttaga ccatatgtgc attcagggga     4920

ctcttgtctt tgccagcact cctcaggtga gcccgggatg gctatctgaa atgtctggaa     4980

aatagagtcc cttccccaaa catctgacat ggccactaaa tctttagact tgccttatag     5040

atccttccat atcatcccca agtgcccctt ctgcctcagt cctgttcctc tgggcaatag     5100

ctctagggaa aagtaggtat tagactgctg tgcaaaattc agagcaacta cttaaaatgc     5160

tctagaggat tcttagccag tctgtgaaag tgggcctcct ctgtggtggg gctgtttggc     5220

ttaggagatg ctgtagtagt agagataatc aggttctatt ttaagcaatc agcagagatc     5280

aatattgtac agatacaagc aaaggtttaa taaatatata tatatatatt tatttctgta     5340

gttgtgccag ggacagactg gccaaagacc aaacactgca gggtccccaa gaaatttgtc     5400

cttatatcat tgtgtctgag ggccagatat gattatgaag ctttttccaa agatccaggg     5460

atgggaatgg gagtgggtag gaggggtaat gcggtcattg gagtcggggg ctggaacatt     5520

atgagtgctc aataaatata aactaatgag aatggtggtg atgga                     5565


<210> 1487
<211> 6773
<212> DNA
<213> Homo sapiens

<400> 1487
cggccgccgc cggccgggcc ccaagccccc gagggcgcca gggcgggatc gcgaccggtg       60

caacttctag ccttgttgtc ctcctggtgc gaagagctcg gccgcctgct gctgctccga      120

catcagaaga gccgccagag cgatccccct gggaaactcc ccatgcagcc ccctctcagc      180

tccatgagct ccatgaaacc cactctgtcg cacagtgatg ggtcgttccc ctatgactct      240

gtcccttggc agcagaacac caaccagcct cccggctccc tttccgtggt caccacggtt      300

tggggagtaa ccaacacatc ccagagccag gtccttggga accctatggc caatgccaac      360

aaccccatga atccaggcgg caaccccatg gcgtcgggca tgaccaccag caacccaggc      420

ctcaactccc cacagtttgc ggggcagcag cagcagttct cagccaaggc tggccccgct      480

cagccctaca tccagcagag catgtatggc cggcccaact accccggcag cgggggcttt      540

ggggccagtt accctggggg tcctaacgcc cccgcaggca tgggcatccc tccgcacacc      600

aggccgcctg ctgacttcac tcagcccgcg gcagccgctg cagcagcggc agtggcagca      660

gcagcagcca cagctacagc cacagccacg gccactgtgg cagccctgca ggagacacag      720

aacaaggata taaaccagta tggaccgatg ggtcccaccc aggcgtataa cagccaattc      780

atgaaccagc ccgggccgcg ggggcctgcc tccatggggg gcagcatgaa ccccgcgagc      840

atggcggctg gcatgacgcc ctcggggatg agcggccctc ccatgggcat gaaccagccc      900

cggccgcccg gcatcagccc ctttggcaca cacgggcagc ggatgcccca gcagacctac      960

ccgggccccc ggccccagtc ccttcctatt cagaacataa agaggccata ccctggagag     1020

cccaactatg gaaaccagca atatggacca aacagccagt tccccaccca gccaggccag     1080

tacccagccc ccaacccccc gaggccactc acctccccca actacccagg acagaggatg     1140

cccagccagc cgagctccgg gcagtacccg ccccccacgg tcaacatggg gcagtattac     1200

aagccagaac agtttaatgg acaaaataac acgttctcgg gaagcagcta cagtaactac     1260

agccaaggga atgtcaacag gcctcccagg ccggttcctg tggcaaatta cccccactca     1320

cctgttccag ggaaccccac accccccatg acccctggga gcagcatccc tccatacctg     1380

tcccccagcc aagacgtcaa accacccttc ccgcctgaca tcaagccaaa tatgagcgct     1440

ctgccaccac ccccagccaa ccacaatgac gagctgcggc tcacattccc tgtgcgggat     1500

ggcgtggtgc tggagccctt ccgcctggag cacaacctgg cggtcagcaa ccatgtgttc     1560

cacctgcggc ccacggtcca ccagacgctg atgtggaggt ctgacctgga gctgcagttc     1620

aagtgctacc accacgagga ccggcagatg aacaccaact ggcccgcctc ggtgcaggtc     1680

agcgtgaacg ccacgcccct caccattgag cgcggcgaca acaagacctc ccacaagccc     1740

ctgcacctga agcacgtgtg ccagccgggc cgcaacacca tccagatcac cgtcacggcc     1800

tgctgctgct cccacctctt cgtgctgcag ctggtacacc ggccctccgt ccgctctgtg     1860

ctgcaaggac tcctcaagaa gcgcctcctg cccgcagagc actgtatcac gaaaatcaag     1920

cggaatttca gcagcgtggc tgcctcctcg ggcaacacga ccctcaacgg ggaggatggg     1980

gtggagcaga cggccatcaa ggtgtctctg aagtgcccca tcacattccg gcgcatccag     2040

ctgcctgctc gaggacacga ttgcaagcat gtgcagtgct ttgatctgga gtcatacctg     2100

cagctgaatt gcgagagagg gacctggagg tgtcctgtgt gcaataaaac cgctctgctg     2160

gagggcctgg aggtggatca gtacatgtgg ggaatcctga atgccatcca acactccgag     2220

tttgaagagg tcaccatcga tcccacgtgc agctggcggc cggtgcccat caagtcggac     2280

ttacacatca aggacgaccc tgatggcatc ccctccaagc ggttcaagac catgagtccc     2340

agccagatga tcatgcccaa tgtcatggag atgatcgcag ccctgggccc cggcccgtcc     2400

ccctatcccc tcccgcctcc cccagggggc accaactcca acgactacag cagccaaggc     2460

aacaactacc aaggccatgg caactttgac ttcccccacg ggaaccctgg agggacatcc     2520

atgaatgact tcatgcacgg gcccccccag ctctcccacc ccccggacat gcccaacaac     2580

atggccgccc tcgagaaacc cctcagccac cccatgcagg aaactatgcc acacgctggc     2640

agctctgacc agccccaccc ctccatacaa caaggtttgc acgtaccaca ccccagcagc     2700

cagtcagggc ctccattaca tcacagtggg gctcctcctc ctcctccttc ccagcctccc     2760

cggcagccgc cacaggccgc tcccagcagc catccacaca gcgacctgac ctttaacccc     2820

tcctcagcct tagagggtca ggccggagcg cagggagcgt ccgacatgcc ggagccttcg     2880

ctggatctcc ttcccgaact cacaaatcct gacgagctcc tgtcttatct ggaccccccc     2940

gacctgccga gcaatagtaa cgatgacctc ctgtctctat ttgagaacaa ctgagggcca     3000

cccggtcggg gccatccctc cacactctgc atcctacccc acctacccaa cacacttttc     3060

cacctgggag cctgtgccct cagaccgccc cgcaccagag ccacgggctg tggggcgggg     3120

agccctcccc cgctgcagcc ctctcagaac agaggggtag ggagggtgca ccagtgcacc     3180

aggaaggctg tgtgggtctg gagcccacgt cccacctcca cacccttggc ttgggcccat     3240

gcccagcgca ggcctgaaga ccaccctccc gagaggaacc agcccggtaa gagggcacac     3300

gctgatgcgg cttcccggtc cctccgcgtg tgccgattcc agatgacctt ccagtgtccc     3360

caaggttctt ccatcttcta gactgtaacc ctgcctccct gcttcctggt ccagagcctc     3420

cctccagtga ctgtggagcc tgagaaggcc cccgggcccc agcatgggcc ccgagccttg     3480

gaggagcact ggcagttggt ggcagtgaga ccagcccacc caccaccacc caccacagaa     3540

aagcacaaac ctctgggaaa gacaacgtct ctcgggggcc aggggtcatc ggtttgaccc     3600

ctgacctata agccaagata ccccataaac acactcagaa agcagagaaa aaggacaaga     3660

gtctgtgttt gagagggggt ctgccattcc tgcttgggga ctggtgggga agagggccag     3720

gacatcttct gagccaggac gtccctgagg ctccacctcc aagctcagac agggcccagg     3780

cttggggaac agagagagca ggtgtacacc caaccaaagt gattgtgccc ttggttgggg     3840

ggcgcgggca tataacctgt cagaagcaaa caggagcggc aacttctaac tttgctccaa     3900

gccactctct ttttaaacag caacaattta aagctatgaa gtcacctgga gaaaaggaac     3960

gttgctcttg gacagcaagc aaaccatttc tctccgtctg ttctgttttt ctcctagtcc     4020

ctctcctgcc acctctccaa gacttccgtg ggacacccac ttccctctgt cctagttctc     4080

tttgtccaat cagatggcaa gggcagtgcg tggaaaggcc ggggaggtgc agaaaccaga     4140

gcccagggca atggtgtctg tccagcccct ccctctgtcc ctgtgctcca agctgccccc     4200

ggctgcagcc caggccatgg acatgtgcac cagtatgtac ctgcaggcat gggggggagg     4260

ggggcgtgtt tctgggcctg ccccagacac tgcccttggc tgccagccta ccctgcctgc     4320

actcctccac catcacaatc tcacccaaac tcctgctcac tcaagcaaaa gcagcctctg     4380

gccttccctc caccgctttg ctccatctgg cttaccactc tccagggcct cctggggagc     4440

ctgtcctgtg ttcactttgt ttcaggctgg tctgtgcccc gtgagccaca tggcctaggg     4500

tgatgccagg ttgtcccgtc actggggtcc catctgtaaa ttctttgcgc ccttcccggc     4560

tgctgcctgg ggccctttcc tgctctcccg tccgctgtgg gtggtcccca gctctcctct     4620

gtgggtttta ccggaaaggt ggccccagct gttgacttcc agtcactgtc ccagacggca     4680

caaggttttc tgtaggaaag ctgccattgc cccggcccct tttcttcctt tgtcccgttg     4740

tcgaggtttt ttcaaatagc gtgttgttca gtatgcaaat caattatttt aagaatcgct     4800

tttgtaaata tctttgtgaa tattttagta tcgtctttga taatattcaa cattttcatg     4860

acctggttat agcctttgct ggtgttttta aaatacctgg actcaatgac aaagaccgag     4920

tcttcttttt ttttaaacaa aaacaaaaaa agcaaccagg gctatttgta cagttgaagg     4980

ggtgaacaga atgggcggct gtgctgggag ttggaagacc gggcagcccg ctatttagag     5040

ccatccctca gtcagctggc agggacaagc caacgccagg tagcatgtgg ccacccttgc     5100

ccagtgtctg tggcctggca agtggccacg ccctgtgtca gaccatctgg gaattaagct     5160

ccagacagac ttacagatgc cttccttagg agttcttgct tcttgcgttg atactttgcc     5220

ccagaaaggc ctgggattca ttctggttct tatcagggtg tgtccacact ctgctcacag     5280

gtggatccac ggctttccag tgcggagagt cgagatgctc cctgcagccc aggccccggg     5340

cacctcctgc aaccatctct gggctcagca cctgaggcgg gtttcctggg tcccctctcc     5400

agcaagcctc caccagcaag ctcggcccag agcttccctt ccggctggct ctgaaccgtg     5460

cgtggtgcct acagcctgca gtctggagac aagctcttcc ggagtgctct gggagccagg     5520

ccagggtgtg agggaggtgc agaggcatcc ggggcgggag caagccccag gttgtgacag     5580

gtgcaggtag acaacgccca taaacagaga tggtcctgaa ctctggagag atccttccct     5640

gatcctttcg gacgactact tggagccata agtaacctca gcaaaaacga ggcctctgca     5700

agccactttt ccatgccaag catccacccg gcccacaggc atgtttctgc cgccactccg     5760

caagatggac agggagccag caggcaggcg ggaagggcca agtacaggca atcaccccca     5820

tcttcttggt ttgaagcttt atccatgtat catgttccgt gtagccattt tattttttaa     5880

gaaactgcta atactttctc cctaatggaa gccctgatcc cccagagagc tacaggtctg     5940

ctcccgacgg gcctcgggcc tgacccgtcc acacagggcc gtgtcaacag cagcgactca     6000

agggacgtgt gtacatatgt aaatgagaaa tagagacgtg tcaacagatg cattcatttc     6060

tcttggaatg tgtattgttt ttattttgcg aaacaaaaca aaacaaaaaa aaaagcttgg     6120

aactccatca cgtggaaaaa ctagatcctg ttggttatag catttgtgag ttctccacgt     6180

ctgtctctct cgctcatgta atatactctg accctgagtg gaaaggggtt tttgttctgt     6240

ttttatttta cctacatgta ctatttagct tcagtgtact agtcctgcca cctgtgtatt     6300

tttagggtgc tatggaaata atgaaaagaa acggggattt cagaagaaaa ttgtaaccaa     6360

attcatactt tgtataattt ttgatatcat gatcacaggt gattcacacg tacacacata     6420

aacacaccca ccagtgcagc ctgaagtaac tcccacagaa accatcatcg tctttgtaca     6480

tcgtatgtac aatgcaatca tttcatactt taaactggtc aaaaaactaa ttgtgatttc     6540

tagtcttgca aagctgtatg tagttagatg atgtgacaac ctctaatatt tatctaataa     6600

atatgtattc agatgaaacc tgtatattag gtgttcatgt ggttattttg tatttaaaga     6660

tcaaattatt tgactattgc tagacatttc tatactctgt tgtaacactg aggtatctca     6720

tttgcccatg ttaatttttt tctaaataaa ttgacaaaaa caaaggtttg gcg            6773


<210> 1488
<211> 6336
<212> DNA
<213> Homo sapiens

<400> 1488
tcgtggggaa aaggcaggga gggggtggtg tccccagccg gtttgggggg tgcgttgccc       60

ggagacggaa agtttgggag cccgagcagg ctcggctgca gcctcgggga gggggtccag      120

cgggtggcgg ccctggggat ggggaaggag caggagctgc tggaggcggc ccgcaccggg      180

cacctcccgg cggtggagaa gctgctgtcc gggaagcggc tctcctcagg ctttgggggc      240

ggcggcggcg gtggctctgg gggcggcggc ggcggcagcg gcggcggcgg cggcggcctc      300

ggctcttcca gccaccccct ctccagtctg ctcagcatgt ggagagggcc aaatgtgaac      360

tgtgttgaca gcactggcta cacacccctg caccatgctg ctttgaatgg ccataaggat      420

gtggtcgagg ttcttctgag gaacgatgcg ctgaccaacg tggctgactc aaaaggctgc      480

taccctctgc atttggcagc ctggaaagga gatgcccaga tagtgcggtt gctcatccat      540

caagggcctt cacacaccag agtcaatgaa cagaacaatg acaacgagac agccctgcat      600

tgtgcagcgc agtatggcca cacagaggtg gtgaaggtgc tcttagagga gctgacggac      660

cccaccatgc gcaacaacaa attcgagacc cctttggacc tggcagcact gtacgggcga      720

ctggaggtgg tgaaaatgct ccttaatgca caccccaacc tcctgagctg caacactaag      780

aagcacaccc ctctgcactt ggcagcaagg aatggccaca aagccgtggt ccaggtcctc      840

ctcgatgctg gcatggacag caactaccag acggagatgg gcagtgcttt gcatgaggct      900

gctttgtttg gcaagaccga tgtggtgcaa atcctgctgg ctgcaggaac tgacgtcaac      960

ataaaagata accatggact gactgcccta gacactgttc gggaactgcc ttctcaaaag     1020

agccagcaaa tagcagcatt aattgaagat cacatgactg gaaaaagaag tacaaaagaa     1080

gtagataaaa cccccccacc ccagccacct ctcatctcca gtatggactc catatcacag     1140

aagtctcagg gtgacgtgga gaaagcagtg actgaactga ttatagattt tgatgcaaat     1200

gctgaagaag agggtcccta cgaagctctg tataatgcca tctcctgcca ttcgttggac     1260

agcatggcca gcgggcgatc atctgaccaa gactccacga acaaggaggc tgaggcagca     1320

ggagtgaaac ctgctggagt gaggcctagg gaacgtccac cacctccagc aaagccaccg     1380

cccgatgaag aggaagaaga ccacatagat aagaagtatt ttcccttgac agcttctgag     1440

gttctgtcca tgagacctag gattcatggg agtgcagccc gggaagaaga cgaacaccct     1500

tatgaactgt tgttaacagc agagacaaag aaagtggtgt tggtggatgg aaaaacaaaa     1560

gaccacaggc ggagcagcag cagccggagc caggactctg cggaggggca ggacgggcag     1620

gtcccagagc agttctcagg cctcctccac ggctcctccc cggtgtgcga ggtggggcag     1680

gaccctttcc agctgctctg taccgctggc cagagccatc cagacgggtc cccccagcag     1740

ggcgcctgcc acaaggccag catgcagctg gaggagacgg gtgtgcatgc tcctggagcc     1800

tcccagccca gtgccctgga ccagagcaag agagtgggct acctcacagg cctgcccacc     1860

accaacagcc gctcgcaccc tgaaactttg actcacacag catctccgca ccctggtggt     1920

gctgaggaag gagaccggag tggggccagg agccgagcgc ctcccactag caaacccaaa     1980

gctgaactca aactcagccg cagcttgtcc aagtctgact ctgatctcct gacctgctca     2040

cccacagagg acgctaccat ggggagtcgg agtgagtcct tatccaactg cagcattggg     2100

aagaaaaggc tagagaagtc accctccttc gcctcggagt gggatgagat tgagaaaatc     2160

atgagttcta ttggagaagg gattgacttt tctcaggaac ggcagaagat ctcaggttta     2220

cggacgctgg agcagagtgt cggggagtgg ctggagtcga ttgggctgca gcagtatgag     2280

agcaagttgc ttctgaatgg ctttgacgat gtccacttcc tggggtctaa tgtgatggaa     2340

gagcaggacc tgcgggacat cggcatcagc gacccacagc accggcggaa gctgctccag     2400

gcggcacgct ccctacccaa ggtgaaggct ctgggttatg acgggaacag cccccctagc     2460

gtgccctcct ggctggactc cctggggctg caggactacg tccattcctt cttgtcaagt     2520

ggttacagct ccattgacac cgtgaagaac ctctgggagc tagagctcgt caatgtcctg     2580

aaggtccagc tgctcggcca tcgcaagcgc atcatcgcct ccctcgcaga cagaccgtac     2640

gaggagccgc cccagaagcc ccccagattc tcccagctga ggtgccaaga tttgctctcc     2700

cagacgtcat ccccactgag tcagaatgat tcctgcactg ggcggtcggc agatctgctg     2760

ctgcctccag gggacacagg caggaggcgc catgacagtc tccatgaccc tgcggcaccc     2820

tcccgagcgg agcgcttcag gatccaggag gagcaccgtg aggccaagct gaccctgcgg     2880

cccccgagcc tggcagcccc ctacgcccca gtgcagagtt ggcaacacca gccagagaaa     2940

ctcatcttcg agtcctgtgg ttatgaagcc aattatctgg gctccatgct gatcaaagat     3000

ctgcgaggga cagaatccac gcaagacgcc tgtgccaaga tgcggaaatc tacggagcac     3060

atgaagaaga tccccaccat catcctgtcc atcacataca aaggtgtcaa gttcatcgat     3120

gcctccaaca agaacgtcat tgcagagcac gagatccgga acatttcctg tgcggcccag     3180

gacccggagg acctctgtac ctttgcctac atcaccaagg acctgcagac cagccaccac     3240

tattgccatg tgttcagcac cgtggatgtg aacctgacct acgagatcat cctgacgctg     3300

gggcaggcct tcgaagtggc ctatcagttg gccctgcagg cccagaagtc cagggcgacg     3360

ggcgcctctg cagctgagat gattgaaaca aaatcttcca aaccggtgcc taagcctcgg     3420

gtcggcgtga ggaaatccgc actggaacca cctgatatgg accaagatgc ccaatcccat     3480

gccagtgtct cctgggttgt ggaccccaaa ccagactcta agcggagcct cagcaccaac     3540

tgagccactg aggaaccaca ctgtgctgcg gaaacataga cgtgggggca taggctccca     3600

ctgccaccac cgccatcgcc tcacctgcag ctctgaagac ccaggcctca cctccgcctg     3660

caggacctcc tcttggccac ttggcctggg cctgccacca ccacgtcctg cagaacgagc     3720

cctgccttgg ctgtggagaa gcactccagg ccgctagcag atgggactgg cattccagag     3780

ggtcaagaag tgacttgttc agaacacatt gtttttaaca gaaaaaaaat ctttttataa     3840

aatgaacttt taacacttgg ctcaaacctc taggtcatac tgccaatctt tagacaaatg     3900

gccatggggc agaggacagg ggagctgagg ttggttcaga ggccagcctg catagcctct     3960

gtcctcagga cggaacttgg gtgcagctca gtgggtcgga agagaaggcg gtggcctgtg     4020

ggtgagggga acggagcagg ctcaggcaga attgagtacg gtgcgtctgc ttttcaaacc     4080

caaccatatc agctgctgct ctttatgaac tgcccaactt cctgtccctt tcaggggcta     4140

gacacaggct tctcgtaaga acacagcctt agaggcacct gagcaactca aaggtttccg     4200

gtccatttct ggggttcccg atgggaaggt tcagtggcca aatgaagata agtgtgcagt     4260

ttctagtgct gggaagtctt agccagcacc agagcgccag gcctctccct ggcctcttac     4320

ctgtcagtga tcggagcact gccctgggct ggccggcgcc gtactgcctg cgttgtgtca     4380

gagaatagga aaagcagctt tgtttggggc attaatgctt ggagtggggt cagctaaggt     4440

tgctacttgc caatttgtga tttgtctaat cagcctgtgt gattggggct cattttgatt     4500

ctctgaatta tcggtttgac ggttacactt ggctgctggg cccatccctg gcccccggtg     4560

tggaaaaggc taaataaggt gacagtgcat cgatgctccc ccgcgtggcc tttggggcag     4620

gctggcatcc cggtgcgcct ctgcttctta agctttcctg ctgctcgctt tgtttttaaa     4680

agtaacttgg gttgcattct tccctctgga ctagagtaga aatgcagggg aaactgctgt     4740

ggatttgaga ggcaaagttg gctcagctgt gtgcccagtt cctcctgtgg gcactttagc     4800

aggctccgag ctttcctggc ataggtcaat caggtcccag gatgaataat ccaggcttca     4860

gcaacactcc tctttcccag ccagcaaagg ctgtgaattt gaattctttg ttggtatgta     4920

tgtgcaggga gtactgttag gcacattctt aacccatgtg gttggccaga aatcagaagt     4980

ggggctgtgt ctctgactgg ctagaggcca ggccttgtgg gtttctatct gctaagcacc     5040

cagcaggttg gggcctggga ctcagctctc tctgcggtag aggcaggccc tcctccactt     5100

cttggtacta aacgaagatc tcgacacctt gcagttttac ttcatttcct gcccctttca     5160

gggcctgtga ggatgcccat gagctaccgc tgtacagttc tcggccccgg ctttcttcca     5220

agagttgacc aggaacccta aagcatccag agtagactgc gctgccactg cgcacatgct     5280

ggtgcccgtc ttcctcctaa ggggccaggc cacatccaag tgggcctctg tcgggggcgg     5340

ggcggtaggt ccgaaagaaa ccgcagacac tacgatgcac tcctcaagct gtcttttgtg     5400

cttagatcat ccataggtgt ttcttctgct tgaagctgct atatcatctt tatttattca     5460

gggtattttc atattggaag ccttggctag tctgctctag ctctgggttc tgtttagaga     5520

ttggtttatt tctgaatatt caagaaagga aaatgactgg gcctttcttt cttttcttct     5580

cctctgggat gggtagtctc cctttcctag aaaggttatt ataactttaa ggacaggctt     5640

caagtgggaa ggcccctact tttgcacttc tccaagtgca ggtcacacca ggggcagacc     5700

ctgtcgctgc gtttctgaac tgtgaaggag cccattcggg tgggagactt cagatgggct     5760

cagtacctgt cccagccaca ggcttcttgt ccacctcttc tcccctgccc accagctgct     5820

cagcgcataa gaccttcccg acaggctctg cgtgtgcagc tctctgcgtc cctcctgggc     5880

cctccagcgt cagacactaa tgggagttcc cgagatgctc gggtttgagc agggagcagg     5940

cagagctgca gtcagagaca ttagaaaacc agtctgaatt gggtctgtct ttgagatgcc     6000

caggccagca gaaagcagct cagaagtatt gttgctcatg gtgtggcaat ggactgaact     6060

gtaatgaaaa tgttatttaa tctttgtctc tgtattttga tacttgaatg actttccctt     6120

ttgttttact gtatataaaa ttgttaatct gtctgatttt gtctgaatta taaacacttt     6180

gaggtaccaa acataaccaa tctgtgcaac aacatagact gacctcagta cccaagagag     6240

tgtaaatatt tctgggcttc cagctttggt tttgttattt tcataactgt acacaactta     6300

gaacagactg aattaataaa tgagaagcga catgaa                               6336


<210> 1489
<211> 3813
<212> DNA
<213> Homo sapiens

<400> 1489
gggaaagttc ccggctgtcg gttggagggt gggtcctcgc cccgccccgc cccctcgggc       60

cgcccttccg cgcttccggg aggcttgtcc caagctcacg gacccctcgc tgggtgccgg      120

ttaagacccc gctccccgtc gccagtgcta tggaggcggc ggcggcggtg gtggcggcag      180

aggcggaagt ggaaaacgaa gacggcgaca gcagctgcgg ggatgtatgc ttcatggaca      240

aaggcttgca gagcatatca gaattatctt tagattcaac tcttcatgcc gtcaatcttc      300

attgcaataa catctccaag atcgaagcca ttgatcatat ttggaattta caacatctag      360

atctgtcatc taatcaaata agtagaattg aaggactaaa cacactgaca aaactgtgca      420

cattaaattt gtcctgcaat ttgattacaa aagtagaagg acttgaagaa ctaattaatc      480

tgactagact aaatgtatct tataaccaca tagatgatct tagtggattg attccccttc      540

atggaattaa gcataaactt agatatattg atctacatag taatcgtata gatagtatcc      600

atcacttact tcagtgtatg gtaggattgc acttcctgac caatcttatt ttggagaaag      660

atggagacga taatcctgtc tgtcgactgc cagggtacag agcagttatt ctccagactt      720

tgccacagct tagaatccta gattgcaaga acatatttgg tgaaccagta aatttgacag      780

aaataaattc atcacagctg cagtgcctag aaggtctttt ggataattta gtttcttctg      840

attctcccct aaatataagt gaagatgaga tcattgatag aatgccagtg ataacagcac      900

ctatcgatga gttagttccc ttggaacagt ttgcaagtac accaagtgat gctgtgttga      960

cgtcttttat gtctgtgtgt caatcttctg agccagagaa aaataatcat gaaaacgatt     1020

tgcagaatga gataaaactt cagaaattag atgaccaaat tctacaactt ctaaatgaaa     1080

cttctaattc aatagataac gttcttgaga aagaccccag accaaaaaga gacacagata     1140

taacttctga aagtgactat ggaaacagaa aagaatgcaa tagaaaagtt cctcgaagat     1200

caaaaatccc ttatgatgcc aaaaccattc aaactattaa gcaccacaat aaaaactaca     1260

actcttttgt aagttgtaat cgtaaaatga aaccacctta ccttaaagaa ttatatgtaa     1320

gctcatcttt agcaaactgt cctatgttac aagaatcaga aaagccaaag actgaaataa     1380

ttaaagtaga ccaaagtcac tcagaagaca acacttacca gtcccttgtt gaacagctag     1440

accaagagag agagaagaga tggagagctg agcaagccga aaataaactc atggattata     1500

ttgatgagct gcataaacat gcaaatgaaa aagaggatat tcatagtctg gctctactta     1560

ccacagatag gctaaaggaa attattttta gagagagaaa ttccaaagga caactcgaag     1620

ttatggttca caaacttcaa aatgaaatta aaaaactgac tgttgaacta atgaaagcaa     1680

aagatcaaca agaggatcac cttaaacact taagaaccct cgaaaaaaca ttagaaaaaa     1740

tggagagaca aaaaaggcag cagcaggcag cacagataag actgatccaa gaggtggaac     1800

tcaaagcttc agctgccgat agagaaatat acttacttag aacttccctt catcgagaaa     1860

gagaacaagc gcaacaactt catcaacttc ttgcattgaa agaacaggaa cacaggaagg     1920

aacttgaaac aagggagttt tttactgatg ctgacttcca ggatgcctta gctaaagaaa     1980

tagccaaaga agagaaaaag catgagcaaa tgataaaaga ataccaagag aaaattgacg     2040

tgttaagcca gcagtatatg gatttagaaa atgaattccg tattgcttta actgttgaag     2100

ccagaagatt tcaagatgtt aaagatggtt ttgaaaatgt tgcaactgag ttagcaaaga     2160

gcaaacatgc tcttatttgg gctcaacgaa aagaaaatga gtcttcctct ttaattaaag     2220

atctgacctg tatggtaaag gaacaaaaaa caaaactggc agaagtttct aaattgaaac     2280

aagaaacagc agcaaattta cagaatcaaa tcaacaccct tgaaatttta attgaagatg     2340

acaagcagaa gagtattcaa atagaacttc tcaagcacga aaaagtccag cttatttctg     2400

agctagcagc caaggaatca ctaatatttg gtttaaggac agaaagaaaa gtatggggac     2460

atgagctggc acaacaagga tcttctctag cccaaaatcg tggaaaattg gaggctcaaa     2520

ttgagagttt atctagagag aatgaatgtc tgcgaaagac aaatgaaagt gatagtgatg     2580

cattaagaat aaagtgcaaa atcatagacg accaaactga aactattaga aaattaaaag     2640

attgtttaca agaaaaagat gaacacatca aaagattaca agaaaagatc acagaaatag     2700

aaaaatgcac tcaagaacaa cttgatgaaa aatcttcaca actggatgag gtacttgaga     2760

agttggaaag gcacaatgaa agaaaagaaa aactaaaaca acagttgaaa ggaaaggaag     2820

tagaacttga agaaatcaga aaagcttaca gtacactgaa tcggaagtgg catgataaag     2880

gagaacttct atgtcatctt gaaacacaag taaaagaagt gaaagaaaaa tttgaaaaca     2940

aggaaaagaa acttaaagcg gaaagagaca aaagtattga actacaaaag aatgcaatgg     3000

aaaaacttca tagtatggat gatgccttta aaagacaagt tgatgcaatt gttgaagctc     3060

atcaagctga aatagcacag ctggccaatg aaaagcagaa gtgtattgat tctgcaaatt     3120

taaaggtcca tcaaattgaa aaagaaatgc gtgaactttt ggaagaaaca tgcaagaaca     3180

aaaaaacaat ggaagcaaaa attaagcaac ttgcttttgc tttaaatgaa attcagcaag     3240

atatgtgatg gttctgagaa tgaatttaat tgaaatagac cagcagacct attgtaaaaa     3300

tgattaaata ttgtaatagt agtaactgct atgactttga aatgtctctt tctatacatt     3360

tcattatgaa tatattttta aagacttttg atcaagtatt tattaattgt ataggttttt     3420

tataataaat tgttgacaat tttgtctatt agaaaaaact atcataacta gacttacaat     3480

atttttcttg tttctgtact atacattgtt tggtaattac acatttgcct acaaatttgt     3540

gaatgaaaag attagtattt tcaccatatg aggtaaaaca ttttaatcat tgttatctta     3600

ttgtgatgat gaagaactaa ttatatttgt tatttaattg atgtagctca attcttttaa     3660

agtacttatg tagccaaaaa gcatttgaaa tctgtatgat aaaagatgtg gcattcttaa     3720

gaaagtatat gtagccatct ccacatcact cattatgacc ccttctttta taatgcttat     3780

atcttttcat taaagattac atttaaggtt tta                                  3813


<210> 1490
<211> 682
<212> DNA
<213> Homo sapiens

<400> 1490
aactcctggt actctagcac cgatctgctt tggagaacct gatcctgaga ctccagcagg       60

atgtcttatc aacagcagca gtgcaagcag ccctgccagc cacctcctgt gtgccccacg      120

ccaaagtgcc cagagccatg tccacccccg aagtgccctg agccctgccc atcaccaaag      180

tgtccacagc cctgcccacc tcagcagtgc cagcagaaat atcctcctgt gacaccttcc      240

ccaccctgcc agccaaagtg tccacccaag agcaagtaac agcttcagga ttcatcagga      300

gcatgagagg ataaggataa ttggctcacc tcgttccaca gctccacttg catcttctca      360

ccaaagcctt ccatggatgc acagggagct tctttctcct taacctgtgg cctgcctgtg      420

atgatctgtg acagcaaaag attccctttc tgaggctgcc atactgccac tgtccaggtg      480

gagctaagaa aaggaagtcc tcagctgtgc cagctcccag agcttcggaa gaaagagcag      540

cagctctctc cctgggaacc atcagacaat tctgttgatg tgttctgtgt ctgtctgtca      600

cctggtcatg agcttctacc acctttgcaa ttgtcattta tctttcactc cctgaataaa      660

gtatctatgc atatatattt gt                                               682


<210> 1491
<211> 1390
<212> DNA
<213> Homo sapiens

<400> 1491
accctcaggg cagagagcag ccctacactc cctacaccac acccatactc agcccctgca       60

ggcaaggaga gaacaggtca ggttcccgag agctcaggaa catggagctg atccaggaca      120

cctcccgccc gccactggag tacgtgaagg gggtcccgct catcaagtac tttgcagagg      180

cactggggcc cctgcagagc ttccaagccc gacctgatga cctgctcatc aacacctacc      240

ccaagtctgg caccacctgg gtgagccaga tactggacat gatctaccag ggcggcgacc      300

tagagaagtg taaccgggct cccatctacg tacgggtgcc cttccttgag gtcaatgatc      360

caggggaacc ctcagggctg gagactctga aagacacacc gcccccacgg ctcatcaagt      420

cacacctgcc cctggctctg ctccctcaga ctctgttgga tcagaaggtc aaggtggtct      480

atgttgcccg aaacccaaag gacgtggcgg tctcctacta ccatttccac cgtatggaaa      540

aggcgcaccc tgagcctggg acctgggaca gcttcctgga aaagttcatg gctggagaag      600

tgtcctacgg gtcctggtac cagcacgtgc aggagtggtg ggagctgagc cgcacccacc      660

ctgttctcta cctcttctat gaagacatga aggagaaccc caaaagggag attcaaaaga      720

tcctggagtt tgtggggcgc tccctgccag aggagaccat ggacttcatg gttcagcaca      780

cgtcgttcaa ggagatgaag aagaacccta tgaccaacta caccaccgtc ccccaggagc      840

tcatggacca cagcatctcc cccttcatga ggaaaggcat ggctggggac tggaagacca      900

ccttcaccgt ggcgcagaat gagcgcttcg atgcggacta tgcggagaag atggcaggct      960

gcagcctcag cttccgctct gagctgtgag aggggctcct ggagtcactg cagagggagt     1020

gtgcgaatct accctgacca atgggctcaa gaataaagta tgatttttga gtcaggcaca     1080

gtggctcatg tctgcaatcc cagcgatttg ggaggttgag ctggtaggat cacaataggc     1140

cacgaatttg agaccagcct ggtaaaatag tgagacctca tctctacaaa gatgtaaaaa     1200

aattagccac atgtgctggc acttacctgt agtcccagct acttgggaag cagaggctgg     1260

aggatcattt cagcccagga ggttgtggat acagtgagtt atgacatgcc cattcactac     1320

agcctggatg acaagcaaga ccctccctcc aaagaaaata aagctcaaaa taaaatatga     1380

tttgtgttca                                                            1390


<210> 1492
<211> 3211
<212> DNA
<213> Homo sapiens

<400> 1492
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc agagtttatt aaccacttaa cctctcagaa ctgaacaaag acaacattgt      300

tcctggaacg ccctcttttt aaaaaagaaa gcataacccc tactgtagaa ctaaatgcac      360

tgtgcatgaa acttggaaaa aaaccaatgt ataagcctgt tgacccttac tctcggatgc      420

agtccaccta taactacaac atgagaggag gtgcttatcc cccgaggtac ttttacccat      480

ttccagttcc acctttactt tatcaagtgg aactttctgt gggaggacag caatttaatg      540

gcaaaggaaa gacaagacag gctgcgaaac acgatgctgc tgccaaagcg ttgaggatcc      600

tgcagaatga gcccctgcca gagaggctgg aggtgaatgg aagagaatcc gaagaagaaa      660

atctcaataa atctgaaata agtcaagtgt ttgagattgc acttaaacgg aacttgcctg      720

tgaatttcga ggtggcccgg gagagtggcc caccccacat gaagaacttt gtgaccaagg      780

tttcggttgg ggagtttgtg ggggaaggtg aagggaaaag caagaagatt tcaaagaaaa      840

atgccgccat agctgttctt gaggagctga agaagttacc gcccctgcct gcagttgaac      900

gagtaaagcc tagaatcaaa aagaaaacaa aacccatagt caagccacag acaagcccag      960

aatatggcca ggggatcaat ccgattagcc gactggccca gatccagcag gcaaaaaagg     1020

agaaggagcc agagtacacg ctcctcacag agcgaggcct cccgcgccgc agggagtttg     1080

tgatgcaggt gaaggttgga aaccacactg cagaaggaac gggcaccaac aagaaggtgg     1140

ccaagcgcaa tgcagccgag aacatgctgg agatccttgg tttcaaagtc ccgcaggcgc     1200

agcccaccaa acccgcactc aagtcagagg agaagacacc cataaagaaa ccaggggatg     1260

gaagaaaagt aacctttttt gaacctggct ctggggatga aaatgggact agtaataaag     1320

aggatgagtt caggatgcct tatctaagtc atcagcagct gcctgctgga attcttccca     1380

tggtgcccga ggtcgcccag gctgtaggag ttagtcaagg acatcacacc aaagatttta     1440

ccagggcagc tccgaatcct gccaaggcca cggtaactgc catgatagcc cgagagttgt     1500

tgtatggggg cacctcgccc acagccgaga ccattttaaa gaataacatc tcttcaggcc     1560

acgtacccca tggacctctc acgagaccct ctgagcaact ggactatctt tccagagtcc     1620

agggattcca ggttgaatac aaagacttcc ccaaaaacaa caagaacgaa tttgtatctc     1680

ttatcaattg ctcctctcag ccacctctga tcagccatgg tatcggcaag gatgtggagt     1740

cctgccatga tatggctgcg ctgaacatct taaagttgct gtctgagttg gaccaacaaa     1800

gtacagagat gccaagaaca ggaaacggac caatgtctgt gtgtgggagg tgctgaacct     1860

tttctggcca tgaaccatta taaaatccca acatatatac tgaaaatact gaaactgctt     1920

tgaaaatttg gaatttctga tacctccagt gggccgagag acacggtggg taaaggatgt     1980

gggcagcagc agggaagaca acagaaacac aaggaggcgg ctgtggccgg gctggactgt     2040

gctggggttt gttgtgatgg ccactcggtg acctggcggt ccctacgcaa tagcagctgc     2100

ctgtggggaa gaagggctgc ccagccagct ggttctcccg ggacaccagc agatccacac     2160

cctgggcacc tccgtgtttg gtcttttttt tcccctgtgt gaaagaagaa acggcacgac     2220

cccttctcaa gctggctcac tcagacacat tgggacaaac cctggacagc catgccagag     2280

agaggccttt gaccggcccc agagctaaaa gcaccagaga aaatcaaatg cttcctactc     2340

agcgtgaccc aacttttcta gtgtgccacg gccccaccac ctcctgcagt acccacacca     2400

tcaccactgc tttctcttcc aacagtgatc tgtattctta gtttcattat tttcttttga     2460

ttgatatgac actatataaa attttcattt gagaatttct caattgtatc tagttaaata     2520

gcacagtttg gaaacttgtc tgagactgac tttatcaata atctaaccga caaagatcat     2580

atccatgtgt atgtggttag acatttttat ttcattgact aacccaggac agtttcagtg     2640

atgcaaattg tgtgccctct ggttcagctg aaacagtcct ggactttcaa aaaccttgaa     2700

taagtctccc acagttgtat aaattggaca atttaggaat tttaaacttt agatgatcat     2760

ttggttccat ttttatttca tttttatttt tgttaatgca aacaggactt aaatgaactt     2820

tgatctctgt tttaaagatt attaaaaaac attgtgtatc tatacatatg gctcttgagg     2880

acttagcttt cactacacta caggatatga tctccatgta gtccatataa acctgcagag     2940

tgattttcca gagtgctcga tactgttaat tacatctcca ttagggctga aaagaatgac     3000

ctacgtttct gtatacagct gtgttgcttt tgatgttgtg ttactgtaca cagaagtgtg     3060

tgcactgagg ctctgcgtgt ggtccgtatg gaaagcctgg tagccctgcg agttaagtac     3120

tgcttccatt cattgtttac gctggaattt ttctccccat ggaatgtaag taaaacttaa     3180

gtgtttgtca tcaataaatg gtaatactaa a                                    3211


<210> 1493
<211> 1960
<212> DNA
<213> Homo sapiens

<400> 1493
aagctgagcc gagccgagcc gagctggggg cgcagagcgc gggaggcggc ggcggcgcgg       60

agcccaggtg gctccgctgc cggatgggag tgccccagtg tgctggatga agctggcgca      120

tgcaccatgt catcatgtgt ctctagccag cccagcagca accgggccgc cccccaggat      180

gagctggggg gcaggggcag cagcagcatc cacctgggca tggagtcctt cattgtggtc      240

accgagtgtg agccgggctg tgctgtggac ctcggcttgg cgcgggaccg gcccctggag      300

gccgatggcc aagaggtccc ccttgacacc tccgggtccc aggcccggcc ccacctctcc      360

ggtcgcaagc tgtctctgca agagcggtcc cagggtgggc tggcagccgg tggcagcctg      420

gacatgaacg gacgctgcat ctgcccgtcc ctgccctact cacccgtcag ctccccgcag      480

tcctcgcctc ggctgccccg gcggccgaca gtggagtctc accacgtctc catcacgggt      540

atgcaggact gtgtgcagct gaatcagtat accctgaagg atgaaattgg aaagggctcc      600

tatggtgtcg tcaagttggc ctacaatgaa aatgacaata cctactatgc aatgaaggtg      660

ctgtccaaaa agaagctgat ccggcaggcc ggctttccac gtcgccctcc accccgaggc      720

acccggccag ctcctggagg ctgcatccag cccaggggcc ccattgagca ggtgtaccag      780

gaaattgcca tcctcaagaa gctggaccac cccaatgtgg tgaagctggt ggaggtcctg      840

gatgacccca atgaggacca tctgtacatg gtgttcgaac tggtcaacca agggcccgtg      900

atggaagtgc ccaccctcaa accactctct gaagaccagg cccgtttcta cttccaggat      960

ctgatcaaag gcatcgagta cttacactac cagaagatca tccaccgtga catcaaacct     1020

tccaacctcc tggtcggaga agatgggcac atcaagatcg ctgactttgg tgtgagcaat     1080

gaattcaagg gcagtgacgc gctcctctcc aacaccgtgg gcacgcccgc cttcatggca     1140

cccgagtcgc tctctgagac ccgcaagatc ttctctggga aggccttgga tgtttgggcc     1200

atgggtgtga cactatactg ctttgtcttt ggccagtgcc cattcatgga cgagcggatc     1260

atgtgtttac acagtaagat caagagtcag gccctggaat ttccagacca gcccgacata     1320

gctgaggact tgaaggacct gatcacccgt atgctggaca agaaccccga gtcgaggatc     1380

gtggtgccgg aaatcaagct gcacccctgg gtcacgaggc atggggcgga gccgttgccg     1440

tcggaggatg agaactgcac gctggtcgaa gtgactgaag aggaggtcga gaactcagtc     1500

aaacacattc ccagcttggc aaccgtgatc ctggtgaaga ccatgatacg taaacgctcc     1560

tttgggaacc cattcgaggg cagccggcgg gaggaacgct cactgtcagc gcctggaaac     1620

ttgctcacga agcaaggcag cgaagacaac ctccagggca ccgacccgcc ccccgtgggg     1680

gaggaggaag tgctcttgtg agaggcagtc cctgcgtgga aagttgctgg gcccccgccc     1740

ccggctcccc cgcacgcatg catccactgc ggccggagga ggccatggag cccgagtagc     1800

tgcctggatc gctcgacctc gcatgcgcgc cgcgtcgcct ctggggggct gctgcaccgc     1860

gtttccatag cagcatgtcc tacggaaacc cagcacgtgt gtagagcctc gatcgtcatc     1920

tctggttatt tgttttttcc tttgttgttt taaaggggac                           1960


<210> 1494
<211> 2154
<212> DNA
<213> Homo sapiens

<400> 1494
aacagatgat tccctgattc tccagagaga ttacacactt cgtttgtggc taaggtgacc       60

caatgaaaga agaaaatgaa agccataaag aaaagtctta cagaagaaga atacctgtac      120

ctggactttt ctcaccaaac agaaggatgc atctttcctc ttcatacatc tgtaacttta      180

tttctgttat cttactgtga ctgtaaaatc tttaaaattt gcttagttgt caccaaagag      240

gtgagtagag atagttcact actaagagat gacctgatcc aggatgttga aatacagatt      300

atttcaaggc aggagctccc accaatagtc caaaattgct gtttgcctgc agtagtagaa      360

cgatcagaca atttttgtag agcaggactt gctgttgtat tgagacacat aatccagaaa      420

tcctatgaag cagacccctt aaagaaggaa cttttggaac ttctgggctt taaaaagact      480

tgcttgaaag cctgtgctga agttagtcag tggaccaggc tatgtgaact caccatccct      540

ttggctattg agaattttct cagagaatct tctgaccagc ccccaactat acctgtagaa      600

atactacagc tagagaaaaa gcttagtgag cctgttagag tgcataatga tgataaactc      660

cgcaggcaga agctcaagca acagaaggct gatggagttg ggcctcccct tactaaggga      720

aaggcaaaga gcaaggtcca cacacaggaa acatctgaag ggttggattc ttcatccaag      780

agtctggaac tgaaagtggc attctcaaag ctcacagtac aggaagaacc agctactacc      840

aacagagagc cttctcacat cagaaaagca aaagcctccg accttccacc tctggagcat      900

gtgtttgcag aagggcttta cttcactctg gcagatattg tgctcttgcc ctgtatccat      960

catttcttgg taattatcag caggaaattt tctgagaagc tggtagaatt tccattgcta     1020

gcctcttggt accagaggat tcaggaagtg ccaggagtaa aaacagcagc ttctaagtgt     1080

gggatccaat ttctccattt accaaagttg ttgacaacct caactgaaca gcatccaaac     1140

ttatgtgaag tcccaggtgt agaagagcaa agcgatcctt tatttatagg aggaccaaga     1200

ccaaccatgg ccaagttaat ggaaaagggc attgaagtga tgttttctcc ccacccttgc     1260

cctacttgga ctcttgattg gaatgttctc cctgcagcag tcagcccaaa ggaaggtaaa     1320

atgtccagtg atcgagcttt gaggaagcag caacagttga acaaccttgt ctatgtggta     1380

acaaatcagg ccaaacctgg tgacagaatt gtggatttct gcagcggtgg gggccatgtt     1440

ggaattgtcc ttgctcacat gctgccatca tgtcaggtta cattaataga aaacaaggaa     1500

ttatcattaa ttcgtgctaa gaagagaagt gatgaactgg gtttaagcaa catttggttc     1560

attcaagcaa atatggaata ttttactggg atgtttaata ttggagtagc attgcatgct     1620

tgtggagtgg caacagacat ggtgattgag cactgtatca aaacacgggc ttccttcgtc     1680

acatgccctt gctgttatgg tttcattcag aacacctcaa agttcaattt tccaaaaagt     1740

gaacaattca agaaaacttt atcatacaag gaacacatga ttctgtgcag atttgcagac     1800

cagacagctg tccagctccc accccaacga aggctcatag gaaaacagtg catgtgcttg     1860

gtggatctgg atcgagcaag agctgcagaa gaatgtggat actccgttca agtgatatcc     1920

atggagccag agagctgctc tcccaaaaat aacatgattg tgggagtccc catttaaaat     1980

gagatattca catttgatat tttgccatcc gtcttcacgt tggatgccca gtggcattca     2040

ggaggttctt ggcataacta ggaaacagca ttagccatct tgaacctatt gtgctcagga     2100

aggaaagcaa cagggaaatc ttggaagtaa aggctccctg caaagcatca caaa           2154


<210> 1495
<211> 632
<212> DNA
<213> Homo sapiens

<400> 1495
gcgggcgctg cggcccctgc tctacctcct agcgccggtg cgcggccgag gccgcactac       60

ctgtctgcgg gaaagcggga tccaccccag gacgtcgggt cgctgccgac ataatgtcaa      120

gtggaaacta tcagcagtca gaggctctta gcaaacccac tttcagtgag gaacaagcct      180

ctgcgttagt ggagtcagtg tttgggttga aagtttccaa ggtccggcca cttcctagct      240

atgatgacca aaactttcat gtctacgttt caaaaaccaa agatggccca actgaatatg      300

tcctcaaaat aagcaacacc aaggctagca aaaatccaga cctgattgaa gtgcagaatc      360

acatcatcat gtttctgaaa gccgctggat ttccaacagc ctctgtgtgt cacactaaag      420

gagacaacac agcttctctc gtgtctgtag atagtggctc tgaaatcaaa agctacttgg      480

tgaggctgct gacttacctc ccaggaagac ccatcgctga gcttcccgtc agcccccagc      540

tattgtatga aattggaaaa ctagctgcca aattggataa gacactgcag gagggtaagc      600

cccgcgttac acccctattg gccaaaaact ga                                    632


<210> 1496
<211> 3233
<212> DNA
<213> Homo sapiens

<400> 1496
acttccggtg cttgccctgc ccatccccgt ggcgggggcg tggccatggc gggggcgctc       60

cggcgggggc gggccctggg ctcccgccct tcgggtccca cagtttccag ccgccgctct      120

cctcagtgcc cggtggccca ggagggcctg ggagcccgaa gccgtccccg agtcgctcct      180

aggtcactgg cgcgatgcgg gccgtcctct cggctgatgg gttggaagcc cagcgaggct      240

agaggccagt cccaaagttt ccaggcatca gggctgcagc ccaggagcct caaggcggcc      300

cggcgggcga ctggacggcc ggacaggtcc cgagcagccc ggcccaccat ggacccctct      360

gcccacaggt cccgagcagc cccgcccaac atggacccag acccccaggc gggcgtgcag      420

gtgggcatgc gggtggtgcg cggcgtggac tggaagtggg gccagcagga cggcggcgag      480

ggcggcgtgg gcacggtggt ggagcttggc cgccacggca gcccctcgac acccgaccgc      540

acagtggtcg tgcagtggga ccagggcacg cgcaccaact accgcgccgg ctaccagggc      600

gcgcacgacc tgctgctgta cgacaacgcc cagatcggcg tccggcaccc caacatcatc      660

tgtgactgct gcaagaagca cgggctgcgg gggatgcgct ggaagtgccg tgtgtgcctg      720

gactacgacc tctgcacgca gtgctacatg cacaacaagc atgagctcgc ccacgccttc      780

gaccgctacg agaccgctca ctcgcgccct gtcacactga gtccccgcca gggcctcccg      840

aggatcccac taaggggcat cttccaggga gcgaaggtgg tgcgaggccc cgactgggag      900

tggggctcac aggatggagg ggaagggaaa ccgggccgtg tggtggacat ccgtggctgg      960

gatgtggaga caggccggag tgtggccagc gtgacgtggg ctgatggtac caccaatgtg     1020

taccgtgtgg gccacaaggg caaggtggac ctcaagtgtg tgggcgaggc agcgggcggc     1080

ttctactaca aggaccacct cccaaggctc ggcaagccgg cggagctgca gcgcagggtg     1140

agtgctgaca gccagccctt ccagcacggg gacaaggtca agtgtctgct ggacactgat     1200

gtcctgcggg agatgcagga aggccacggc ggctggaacc ccaggatggc ggagtttatc     1260

ggacagacgg gcaccgtgca tcgtatcacg gaccgcgggg acgtgcgcgt gcagttcaac     1320

cacgagacgc gctggacctt ccaccccggg gcgctcacca aggccctggg ccgcgtcggg     1380

aaggtggtga aagtgtttgg agacgggaac ctgcgtgtag cagtcgctgg tcagcggtgg     1440

accttcagcc cctcctgcct ggtggcctac cggcccgagg aggatgccaa cctggacgtg     1500

gccgagcgcg cccgggagaa caaaagctca ctgagcgtgg ccctggacaa gcttcgggcc     1560

cagaagagtg acccagagca cccgggaagg ctggtggtgg aggtggcgct gggtaacgca     1620

gcccgggctc tggacctgct gcggaggcgc ccagagcagg tggacaccaa gaaccaaggc     1680

aggaccgctc tgcaagtggc tgcctacctg ggccaggtgg agttgatacg gctgctgcta     1740

caagccaggg cgggcgtgga cctgccggac gacgagggca acacggcact gcactacgcg     1800

gccctgggga accagcccga ggccaccagg gtgctcctga gtgctgggtg ccgggcggac     1860

gccatcaaca gcacccagag cacagcactg cacgtggccg tgcagagggg cttcctggag     1920

gtggtgcggg ccctgtgtga gcgcggctgt gacgtcaacc tgcccgacgc ccactcggac     1980

acgcccctgc actccgccat ctcggcgggc actggagcca gcggcattgt cgaggtcctc     2040

acggaggtgc caaacatcga tgttaccgcc accaacagcc agggtttcac cctgctgcac     2100

catgcctccc tcaagggtca cgcgctagct gtgagaaaga ttctggctcg ggcgcggcag     2160

ctggtggacg ccaagaagga ggacggcttc acggcgctgc atctggctgc cctcaacaac     2220

caccgcgagg tggcccagat cctcatccgg gagggccgct gtgacgtgaa cgtgcgcaac     2280

cggaagctgc agtccccgct gcatctcgcc gtgcaacagg cccacgtggg gctggtgccg     2340

ctactggtgg acgctgggtg cagtgtcaac gccgaggacg aggaggggga cacagccctg     2400

cacgtggcgc tgcagcgtca tcagctgctg cccctggtgg ctgatggggc cgggggggac     2460

ccagggccct tgcagctgct gtccaggcta caggcctcgg gcctccccgg cagcgcggag     2520

ctgacggtgg gcgcggcggt cgcctgcttc ctggcgctgg agggcgccga cgtgagctac     2580

accaaccacc gcggtcggag cccgctggac ctggccgccg agggtcgcgt gctcaaggcc     2640

cttcagggct gcgcccagcg cttccgggag cggcaggcgg gcgggggcgc ggccccgggc     2700

cccaggcaaa cgctcgggac ccccaacacc gtgacgaacc tgcacgtggg cgccgcgccg     2760

gggcccgagg ccgctgagtg cctggtgtgc tccgagctgg cgctgctggt gctgttctcg     2820

ccgtgccagc accgcaccgt gtgtgaggag tgcgcgcgca ggatgaagaa gtgcatcagg     2880

tgccaggtgg tcgtcagcaa gaaactgcgc ccagacggct ctgaggtggc gagcgccgcc     2940

cccgcccccg gcccgccgcg ccagctggtg gaggagctgc agagccgcta ccggcagatg     3000

gaggaacgca tcacctgccc catctgcatc gacagccaca tccgcctcgt gttccagtgc     3060

ggccacggcg catgcgcccc ctgcggctcc gcgctcagcg cctgccccat ctgccgccag     3120

cccatccgcg accgcatcca gatcttcgtg tgagccgcgc cgtccgccgc gcccgagctg     3180

ccttcgcgtg cccccgccct gtgttttata aaaagaaaga ttctcggacg ttg            3233


<210> 1497
<211> 4252
<212> DNA
<213> Homo sapiens

<400> 1497
ggcggctccg gagtccggga ggctctggct gctccagtcg cgggtccggg ccccgcctct       60

ccactcggcg gtggcgtccg tgttgttatt gtggtggtag cggcgtctgg ctgctgcgga      120

ccccgccgag tcctagcgcc tggcctgcgc gccgctgccc gcgccacagc cccatcactg      180

agaagaattt tttcactgta tagttgcctc tgcacttaaa gcaggcttgg tccatgaatc      240

ccatgacaag agctttgagg acatgaggag cattctttgt tcaaacatac tgtgttttcc      300

tttggatcac tggattaatt tatttttgga aatcaagtgc aatattggaa gccatttcta      360

ctaattttat ttcactttta aatttatgat ttgatttgaa tactatcatg ggaggagctg      420

tgagtgctgg ggaagataat gatgacttaa ttgataattt aaaagaagct cagtatattc      480

gtactgaaag agtggagcaa gccttcagag cgattgatcg tggagattac tatttggaag      540

gctacagaga caatgcttac aaagacttag cctggaagca tggaaacatc cacttgtcag      600

caccttgcat ttattctgaa gttatggaag cattgaaact tcaaccagga ttgtcttttc      660

ttaacctggg aagtggaacc ggatatttaa gtacaatggt gggcttaatt ttaggtcctt      720

ttggaataaa tcatgggatt gagcttcatt cagatgtggt ggaatatgcc aaggaaaaac      780

tggagagctt catcaaaaat agtgatagct ttgataaatt tgagttctgt gaacctgcat      840

ttgttgttgg taattgcctc cagatagctt ctgacagtca tcagtatgat cgaatttatt      900

gtggagctgg agtgcagaaa gaccatgaaa actacatgaa aatattacta aaagttggag      960

gcatattagt catgcctata gaggatcagt taacacagat tatgcgaact ggacagaaca     1020

cttgggaaag taaaaatatc cttgctgttt catttgctcc acttgtgcaa ccaagtaaga     1080

atgataatgg caaaccagat tctgtgggac tccctccctg tgctgtcagg aatctacagg     1140

acttggctcg tatttacatt cgacgcacac ttagaaattt cataaatgat gagatgcagg     1200

ccaaggggat tcctcaaagg gctccaccca aaaggaaaag aaagagagtt aaacagagaa     1260

ttaacactta cgtatttgtg ggtaatcagc ttattcctca gcctctagac agtgaagagg     1320

atgaaaaaat ggaagaggat aacaaagaag aggaggaaaa agatcacaat gaagcaatga     1380

agccagagga gccacctcaa aatttactga gagaaaaaat catgaagctg cccctccctg     1440

aatctttaaa agcttacttg acatatttta gagacaaata acttagatca agaagaaaaa     1500

tgcctactga taattccttt agtcttgaaa atgtagcatt tgttaggagt taaaagagag     1560

aattatttct ttcatcagag caaattatag tggaaaaaaa atcacttgtt tctgtcagta     1620

acacaaatga tgtattcagt gaataaaaga atccctttta taaaatctat ttttctttaa     1680

atcttggaaa aatgttgttt tagctcagag tgatttcaaa gtggaatgca acagtagtca     1740

agacttgtgt actataaatc cttttctgat tccttacaga tttgtagtga tgaggtttag     1800

atttaatttt atatatggtt taaataattg ttaagcttat ataacctgat ctgaattgca     1860

gttgtttgca tttcctctat gaaaacttca tttatctaat aaggaagtca aatgctttgt     1920

agactattta ccttactttt gttgcaatca ctgttgttgg gttgctgtat atatattccg     1980

ggcaatatat gagtgcaata acaatacaag atattgaata atttagcttt aaaaaatccc     2040

acaaatttta tgaaatttta cagccctgct acttttgctt ttgaatctct tgccaaaaga     2100

catgggtaaa atatctgcct ctctcataga gattttaaga gcacagcaag tgaattatta     2160

aaacaaagtc tatacttaat acaactcttt atatggaccc tttacatttt cagtatttaa     2220

aaaaatgagg ttatcttaac tctatagaat tttaaaagta tatttagaat tgttttttct     2280

gtagttcact gtataaagta tttggttttt taaaaaaagc aaaaccattg ttatgtgtga     2340

ctcttgatag gacacagaac gagtgaatga gcatgagtga ggccactttc ttggatggct     2400

gtaagtagca gggccagggt agacctggtc agcggatgca ctttagcaga tggaacttct     2460

agtttatctg aatatttatc tttgacaagg tagggctgag cctacatttg cttttgatct     2520

atctagtata agaaatattc acagaaattg tatgtagata ccctttgttt tgaaaatgct     2580

gttcagaatc atagtgtaat ctttgggacc tatgccatgt tcatttcact ccttcccata     2640

ttttttgtgt ttcttttggt aaaactataa tggttttcat tttttactta atatcacaca     2700

gttaaactgt ccatatttga gctttatttt agcttatcag tgataaaaaa caggtagtaa     2760

ctgccattgt ttgtttgttt tcctaataag gcctgaaaac agccattcct tgttaagaaa     2820

gtgtacaatg taacatattt gctagagtta catggattat atatttctta aagggaaaaa     2880

tttgagagta tcatggacta ccaccagcat tattattaca gtagttactc agatttggtt     2940

aaggaagccc aagcaatgta tagtgaaagg attattatct ctctgctaag attcagatat     3000

tgtttcagaa atctcagctc cagtaattcc acaacatcta aaaacaaatg tttgtgatca     3060

tgtgtaagca tgaaattgtt ccaagtaagt gaggatattt tagttatgtg aaagacagtt     3120

tcatggaagg tatttgtttt ataccagtgg ctgggatggt ggaattgggg ttatttctac     3180

aattattctt agacgattac taaactgtta agaaatgccc catatcattt ttgtatctag     3240

gaaagaaaaa aatcagtttc atactgttgt catctgtcag aaatgctcat tttattttga     3300

attaaatgtg gcttttgaag tacctagtta ccttgaattc ctggtgacca catgttttta     3360

tctggaaaac ctggagaaag ttatctgtcc catctcccct gcttgttttt tttttttttt     3420

ttggttggag ctgctgttta gatgatgctt ttactatgca ggagagagtt tttgttaagg     3480

atatatttga agattggctt ttccatattg tccttcattc tttgaccatg gcaaagtgta     3540

cagtagattt tcatgatcat tgcatatttc ttgtcattga aatgtatctt ttatgttttt     3600

aaatgcattc attttacact tgtgagttta tcattgactt taagaggtag aaatgaaaaa     3660

tgaaaattaa agctaaagcc tttttatcta ttaatgcaga tatattagaa taagaatatt     3720

ttgggtttgt gtttattttt taatgaattt atgtttactt gatatggaaa attacgcttt     3780

ataggtggaa aagtagcaaa taaagattaa gtaaaagtaa gtgaaaatga tggggaatat     3840

agtattggaa ttttatagct agttaaaaca gtaagtatca tctaatttgg gtgtttattt     3900

tgcagatgag aaaacagacc tagaaccgtg gcatgttttg cctgaaacat acagtgagtt     3960

agagacaggg cctaagatag cttctagcat cagatcaatc ccaagaatcc atcagcaacc     4020

tcagaccaac ccaagaagat aatttaaatc tatactgctt attggtcaat atatttggtt     4080

ctagtattaa taaagaaaaa tgttattaaa atagcataca tagtagtaaa ataaaataca     4140

aaaagtgtgt tgatttatag ctgtttgaga tgataaaagt gaagcaaagc ctgttaaatc     4200

attggaagac ttggaaaatt attttaaata aacaattaca tgtaattaag ca             4252


<210> 1498
<211> 1156
<212> DNA
<213> Homo sapiens

<400> 1498
gtcgcattgg tttatagata gacgtaatca atggatggca ttgcaaggag catccagttt       60

tatggagggt ggaagcctca cttccttggc tataataaag agttctgatg catcttcata      120

caacaagagg aagagtctgc acgcagaagc accaccttct agggataaat aaagggtcaa      180

gctaaggaag ggcagaacaa acttcagaca ctcacttctt tgcctcaact tcagcctgct      240

ctcacaacct cactatgtct tgccccaact actgctcggg aaactccaac tcaggatctc      300

tcagaacctc ccgccatatt cctctcacct ccatcgacct ctgccctacc agcgtgagct      360

gtggagatgt cctctactta cccactagct ctcaagacca tacctgggtc acagacaact      420

gccaagagac ctgcggtgaa ccaaccagct gccagccggt ccactgtgag accggcaatc      480

ttgaaacctc ttgcggttct tccactgctt actacgtgcc caggccttgc caaggaagca      540

gttttcttcc tgcttctttc ttctccagtt cctgccttcc agtatcctgt agaccacaga      600

ggtatgtgtc cagcggctgt cgtccactga ggccgctgct caatagttac cagcccatag      660

gagactgtgt gcccaatgcc tatcgccccc aattctgctt gtccaagagt tgccagcccc      720

aaaacctcct cacttctgga tgccaaccct cgagttgctt ggcctatcgt cctcaaagtc      780

ttcacgttgt gtccagcagc ctcagacctc tggggcctct gttcagtggt tgccaacctc      840

tgacccatgt gttcagcacg tgtcgtccat cttgctctgg actgtgaaac cagcagcttc      900

tttgttccag tgaataatca ctctgagcat ccacaacaaa aattcaaact ccatggactt      960

ttgcttcttt gctagtagca actgatgttt cttagtttta ctgtgcctga tctaatgcaa     1020

gctgcttctc tcgcatgttt tatcttgttt tcatctttcc ttgacatcaa aaaaattagt     1080

ttacaatgct attcaatgtt gctctggtct gggaagaatg tatttgtttt gcactataat     1140

aaatgcgatt aagtcc                                                     1156


<210> 1499
<211> 1157
<212> DNA
<213> Homo sapiens

<400> 1499
tgggtccgtg gcggcgggag gggtggcctc ctgcgctggt cgccccaggg gacctgagag       60

gcgcgacaaa cagtcggcgc gtttggtact cgcgcctgca gagctttcaa cctccgcgcc      120

ggctgcgcct gtttctcggc caggggagca aggccacgcg gcctacgcag ccgagtcgga      180

accaaccggt tgtttggtga aacctacccc agagcctccc gcggcccaca gagcacagac      240

tgtttttgcc aaccatggca tctggagatg acagtcctat ctttgaagat gatgaaagcc      300

ctccttacag cctagaaaaa atgacagatc tcgtagctgt ttgggatgtt gctttaagtg      360

acggagtcca caagatcgaa tttgaacatg ggactacatc aggcaaacga gtagtatatg      420

tagatggaaa ggaagagata agaaaagagt ggatgttcaa attagtgggc aaagaaacat      480

tctatgttgg agctgcaaag acaaaagcga ccataaatat agacgctatc agtggttttg      540

cttatgaata tactctggaa attaatggga aaagtctcaa gaagtatatg gaggacagat      600

caaaaaccac caatacttgg gtattacaca tggatggtga gaactttaga attgttttgg      660

aaaaagatgc tatggacgta tggtgcaatg gtaaaaaatt ggagacagcg ggtgagtttg      720

tagatgatgg gactgaaact cacttcagta tcgggaacca tgactgttac ataaaggctg      780

tcagtagtgg gaagcggaaa gaagggatta ttcatactct cattgtggat aatagagaaa      840

tcccagagat tgcaagttaa tgaattttca tcttaagaag taaagatcag gactttttaa      900

ttactgtggt aattaaatgt gttcagtatg tacttatcag tacatttagt ctgcaatgtt      960

ttaatttttt aaaaagttac atgaaactaa cattccaagg gtcaggaaaa aaaccaatta     1020

tgtatagtca taaaaattac aatttatgat gcaaataatg taaaatgttt taaagacaaa     1080

tggcaaataa gatatggacc aaagtcacta atgttttaca acagtaacct ttactataat     1140

aaatactttt aaaaaaa                                                    1157


<210> 1500
<211> 5996
<212> DNA
<213> Homo sapiens

<400> 1500
gcgggaagca gctcttgtgg atcctcagtg gcggaggctc ggtcacccgg ataggtaaag       60

gaaaacatgc ctgccacacg gaagccaatg agatatgggc atacagaggg acacacggag      120

gtctgttttg atgattctgg gagttttatt gtgacttgtg gaagtgatgg tgatgtgagg      180

atttgggaag acttggatga tgatgatcct aagttcatta atgttggaga aaaggcatat      240

tcatgtgctt tgaagagtgg aaaactggtc actgcagttt ctaataatac tattcaagtc      300

cacacatttc ctgaaggagt tccagatggt atattgactc gcttcactac aaatgcaaac      360

catgtggtct ttaatgggga tggtactaaa attgctgctg gatctagtga ttttctagtc      420

aaaattgtgg atgtgatgga tagcagccaa cagaaaacat ttcgaggaca tgatgcccct      480

gttttaagtc tttcctttga tcctaaggac atctttctgg catcagctag ttgtgatgga      540

tctgtcagag tgtggcaaat ttcagatcag acatgtgcta ttagttggcc actgctacaa      600

aaatgcaacg atgtgataaa tgcaaaatca atctgcagac ttgcttggca gccaaaaagt      660

gggaagttac tggcaattcc tgtggaaaaa tctgttaagc tatatagaag agaatcttgg      720

agtcatcaat ttgatctttc agataatttc atctctcaga ccctcaatat agtaacctgg      780

tctccctgtg ggcaatattt agctgcaggt agtattaatg gtctaatcat agtttggaat      840

gtggaaacca aagactgcat ggaaagggtg aaacatgaga aaggttatgc aatttgtggt      900

ctggcatggc atcctacttg tggtcgaata tcgtatactg atgcggaagg aaatctaggg      960

cttctagaga atgtttgtga ccccagtgga aagacatcaa gcagtaaggt atctagcaga     1020

gtggaaaagg attataatga tctttttgat ggagatgata tgagtaatgc tggtgatttt     1080

ctaaatgaca atgcagttga gatcccttct ttttcaaaag ggattataaa tgatgatgag     1140

gatgatgaag acctcatgat ggcttcaggt cgtcctagac agcgaagtca catcctagaa     1200

gatgatgaaa actcagttga tatttcaatg ctaaaaactg gttctagtct tctcaaagag     1260

gaggaggaag atggtcaaga aggcagcatt cacaatctac cacttgtaac atcccaaagg     1320

ccattttatg atggacccat gccaactccc cggcaaaagc catttcagtc aggttctaca     1380

ccgttgcatc tcactcacag attcatggtg tggaactcta ttggaattat tcgctgctat     1440

aatgatgagc aagacaatgc catagatgtg gagttccatg atacctccat acaccatgca     1500

acacacttat caaacacttt gaattataca atagcagatc tttcccacga agctattttg     1560

ttggcatgtg aaagcactga tgaactagca agcaagcttc actgcctgca ctttagttct     1620

tgggattcaa gcaaagagtg gataatagac ttgcctcaga atgaggatat tgaagccata     1680

tgtctcggtc aaggatgggc tgctgccgct actagtgccc tgcttcttcg attgtttact     1740

attggagggg ttcaaaaaga ggtattcagc cttgctggac ctgtggtgtc aatggcagga     1800

catggagaac agcttttcat tgtttatcac agaggtacag gatttgatgg ggatcagtgc     1860

cttggagttc aactgctaga gctggggaaa aagaaaaaac aaattttgca tggtgaccct     1920

cttcctctta caaggaaatc ctaccttgca tggattgggt tttcagctga aggtacccct     1980

tgttacgtgg attcagaagg aattgttcga atgcttaaca gaggacttgg taatacgtgg     2040

actcctatat gtaatacaag agagcactgc aaaggaaaat ctgatcacta ctgggtggtt     2100

ggtatccatg aaaatcccca gcaactaagg tgcattcctt gtaaaggttc tcggtttccc     2160

ccaacccttc cacgccctgc tgttgctata ttatccttta agcttcctta ctgtcagatt     2220

gcaacagaga aaggacaaat ggaggagcaa ttttggcgtt cagttatatt tcacaaccac     2280

cttgattatt tagctaaaaa tggttatgaa tatgaagaga gcactaaaaa tcaagcaaca     2340

aaagagcaac aggaactttt aatgaaaatg cttgcgcttt cttgtaaact ggagcgagaa     2400

ttccgttgtg tggaacttgc tgatctaatg actcaaaatg ctgtgaattt agccattaaa     2460

tatgcttctc gctctcggaa attaatactg gctcaaaaac taagtgaact ggctgtagag     2520

aaggcagccg aattgacagc aacccaggtg gaagaggaag aagaagaaga agatttcaga     2580

aaaaagctga atgctggtta cagcaatact gctacagagt ggagccaacc aaggttcaga     2640

aatcaagttg aagaagatgc tgaggacagt ggagaagctg atgatgaaga aaaaccagaa     2700

atacataagc ctggacagaa ctcgttttcc aaaagtacaa attcctctga tgtttcagct     2760

aagtcaggtg cagttacctt tagcagccaa ggacgagtaa atccctttaa ggtatcagcc     2820

agttccaaag aaccagccat gtcaatgaat tcagcacgtt caactaatat tttagacaat     2880

atgggcaaat catccaagaa atccactgca cttagtcgaa ctacaaataa tgaaaagtct     2940

cccattataa agcctctgat tccaaagccg aagcctaagc aggcatctgc agcatcctat     3000

ttccagaaaa gaaattctca aactaataaa actgaggaag tgaaagaaga aaatcttaaa     3060

aatgtattat ctgaaacccc agctatatgt cctcctcaaa acactgaaaa ccaaaggcca     3120

aagaccgggt tccagatgtg gttagaagaa aatagaagta atattttgtc tgacaatcct     3180

gacttttcag atgaagcaga cataataaaa gaaggaatga ttcgatttag agtattgtca     3240

actgaagaaa gaaaggtgtg ggctaacaaa gccaaaggag aaacggcaag tgaaggaact     3300

gaagcaaaga agcgaaaacg tgtggttgat gaaagtgatg aaacagaaaa ccaggaagaa     3360

aaagcaaaag agaacctgaa tttgtctaaa aagcagaaac ctttagattt ttctacaaat     3420

cagaaactat cagcttttgc atttaagcag gagtaaagga agaaagtgac cctagggaag     3480

taatggattt ttttttactc atctttgaat atagactcga gtctttggga aactcattat     3540

atatatattt tttaaagagt ttgaagcaac tgtttgtctt tataagataa tgtagtaatt     3600

atattggtgt aggtaacagg acatatgtaa aaactatcat ctttgcagat tactctgcct     3660

ccaaatgcag ggcctttcag agatgcattg tgattgtaat tactgagttg aagctccaac     3720

caatttgaat ttgtttctta accttgaaaa atcattaaag ccaaggtatt aaaacctttg     3780

tgcattaata ccttctaggg gtttggttca tttggttttt gtcatgtgca aggaaggaca     3840

atagtcctct ttccaagtgt gttagcatag acttctctat atgtttctac tagacctagg     3900

ggatgacgtc ttttaataat actggcccta aacatgtaaa taatcttgta ggtgagactt     3960

tttcttttgt gtttcggaaa tttcctatgt ggctttcagt tgtctgtttg tatagcctgg     4020

atttttttga ggtaaatgaa actttctcat ttgtatattt ggcttgatat ggtcttaata     4080

ttatctttcc acgaaatgga tatatttcta gaaaatatat atttactacc ataatttcta     4140

ccaccacccc cattttgctc tgcattatac acagtagaga agaactgaag acactgctgt     4200

gacagtattg cagtccaagg catcatgtgc tcttggtggg atactctgat tatcagcatc     4260

aacagtactt tactgagcaa gactttgaag gcctgagaag agagcaaagt tatggaaagt     4320

atttaactct tattttatat tgaacaaaca aggtttaatc atgtcataca tttttggttt     4380

tctaagcaga gactaataca aatgcagcca cataaaggca gtgtactggg ggtgggaggg     4440

aaggaaacaa tcacataaaa tcagctgact caaaattgag gatagttaat aggttgaaag     4500

ggaaaaagta tgttgaaaat ttagacataa atgaaccaag aatattcctt atctggtgat     4560

gattaaagtt aggaaaacat acatttttta ttttttaatt agtagctgct atcagagaca     4620

ttatagcaca gtggttatga gcacagattc caaagccaga ttacctaggt tcggagaccc     4680

gcttctctac ctactactaa tagttgggtc atgttgggcc ggtgacccaa attctagcct     4740

tcattcactc atctgtaaaa tggatataat gatagtacct actttatagg ttgttatgag     4800

aattgaatga aatgaaagcc cttagtttct gacacatagt aatcttttat ataaatgtta     4860

gttactattc tgataatgat gatgctgttg gttatttcat cttgctttgt cattaggttt     4920

gattctgaat actatacaaa ctaattttga tttcaagatc ttaagtaaag gtttatttat     4980

agtacattgg aaagcatgtt tgtagacatg tattttgtgt ttggttcctc aacttgcttt     5040

gtatatattt tataatacta ggttgatata aaagtaaatg cagtttcgcc atttcagtgg     5100

caaaaaccgc gatttctttt gtgccaacct aatgcttaag gatataatct gtgtatattg     5160

tatttcagat tcatagcaac ctaataacaa ggatttacaa aagggttttt acttccctac     5220

ttttttttgg ctgaaggaag gtttttgtat tgacttggtt taacttacaa atcagaactt     5280

tgaaaccaag aaacattatc cttatttctc tgctatataa tagtaaacct gtttttttcc     5340

agtgttcttt tttttttttc cagagaattg ggactgaata gtatgaaagt gaaaatggaa     5400

ataaattaat tattaatcat catcatatca ataatattgc ctacttgagc ttattgtata     5460

ctatagaaaa ttgacatata cttaatttta ttctccaaaa gcaaaaactc ctcacaggag     5520

gttactttac agatttattt tggagaacaa gtgaataggc actggggtta tgtgcagctc     5580

tggggactgt gctatgatct aaagcctctc atatctgtgc agcaacctgg ggtgagtcac     5640

tgtcactaac atggaacaga tgccaggtag tccctttgga caaaaggatg aggcccatcc     5700

atgtagaaag catcttaatc agtgactgtc ttatgggccc tctttgtttc ccatctgttt     5760

tattatcaga atatataatt ttcccccaag ttttcatctt gaatctctca aacctacaga     5820

aaatttgaaa tttgacagta agcacctgta tatccttcct ctagtttgtc ttattgttga     5880

cattttatca tgtatgcttt atagacagga tttttcctga accatttgga atatgcatat     5940

acttcatccc tcagttccca gcatgtaccc taagaataaa gattttcttc tgcata         5996


<210> 1501
<211> 1576
<212> DNA
<213> Homo sapiens

<400> 1501
agtgggtctt ctcactcttt tccaggctcc ttggaggtca ctgccctgat gacaacatgg       60

tcttcccttc aaggaagcca cgtttctaag agggctctgg catatgcatt ggtggtcact      120

aactgccaag agagaatcca gcattggaag aaggtagata atgactataa tgcccttcga      180

gaaagactca gcaccttgcc tgataaattg tcttataata taatggtacc atttggccct      240

tttgccttca tgccaggaaa acttgtccat actaatgaag tcactgtttt actgggggac      300

aactggtttg caaagtgctc agcaaagcag gctgtaggtt tagttgagca ccggaaagaa      360

catgtaagaa aaacaataga tgacttaaaa aaagtgatga aaaattttga atccagagtt      420

gaattcacag aagatttgca gaaaatgagc gatgctgcag gtgatattgt tgacatacga      480

gaagaaatta aatgtgactt cgaatttaaa gcaaaacacc gaattgctca taaaccgcat      540

tccaaaccaa aaacttcaga tatttttgaa gcagatattg caaatgatgt gaaatccaag      600

gatttgctag ctgataaaga actgtgggct cgacttgaag aactagagag acaggaagaa      660

ttgctgggtg aacttgatag taagcctgat actgtgattg caaatggaga agatacgaca      720

tcttctgaag aggaaaagga agatcgtaac acaaatgtga atgcgatgca tcaagtaaca      780

gactctcata ctccttgtca taaggatgtt gcaagttcag aaccattcag tggtcaagtg      840

aatagtcagt tgaactgttc agtgaatggt tccagttctt accacagtga tgatgatgat      900

gatgatgatg atgacgacga cgacgacaac attgacgacg atgatggtga taacgaccat      960

gaggctttag gggttggaga taattctata ccaacaatat atttttcaca tactgttgag     1020

cctaagaggg tccgaataaa tactggaaag aataccactt taaaattcag tgaaaagaaa     1080

gaagaagcca aacgtaaacg aaagaacagc actggcagtg gccactctgc ccaggagctg     1140

ccgaccatca ggacgcctgc agacatttac agagcctttg ttgatgttgt gaatggagaa     1200

tatgtccctc gcaaatccat cctgaagtct cgaagtagag agaatagtgt gtgtagcgac     1260

actagtgaaa gcagtgctgc tgaatttgat gataggcggg gagttttgag gagtatcagc     1320

tgcgaagaag ccacttgcag tgacaccagt gagagcattt tggaagagga accacaagaa     1380

aatcaaaaga aacttttgcc cttatcagta acacctgagg ttttgcggct agttggctat     1440

tcaagaaacc tcgcccctct gaatgtcata ctgtaatctt taaggaagaa agctacatga     1500

attaattgta ctctatggga aaatttcttt ggaaagatat tttgtaaaac ttttttttcc     1560

aagtaaaaac tttatg                                                     1576


<210> 1502
<211> 2369
<212> DNA
<213> Homo sapiens

<400> 1502
agcggaccga cgcgacacgc cgtgcgcctc cgcggctgcg ctacgaaaac gagtcccgga       60

gcggccccgc gcccgccgca cccggccctc gcccgcccga agacaggcgc caagctgccc      120

cgccgtctcc ccagctagcg cccggccgcc gccgcctcgc gggccccggg cggaaggggg      180

cggggtcccg attcgccccg cccccgcgga gggatacgcg gcgccgcggc ccaaaacccc      240

cgggcgaggc ggccggggcg ggtgaggcgc tccgcctgct gcgcgtctac gcggtccccg      300

cgggccttcc gggcccactg cgccgcgcgg accgcctcgg gctcggacgg ccggtgtccc      360

cggcgcgccg ctcgcccgga tcggccgcgg cttcggcgcc tggggctcgg ggctccgggg      420

aggccgtcgc ccgcgatgct gctctccaag ttcggctccc tggcgcacct ctgcgggccc      480

ggcggcgtgg accacctccc ggtgaagatc ctgcagccag ccaaggcgga caaggagagc      540

ttcgagaagg cgtaccaggt gggcgccgtg ctgggtagcg gcggcttcgg cacggtctac      600

gcgggtagcc gcatcgccga cgggctcccg gtggctgtga agcacgtggt gaaggagcgg      660

gtgaccgagt ggggcagcct gggcggcgcg accgtgcccc tggaggtggt gctgctgcgc      720

aaggtgggcg cggcgggcgg cgcgcgcggc gtcatccgcc tgctggactg gttcgagcgg      780

cccgacggct tcctgctggt gctggagcgg cccgagccgg cgcaggacct cttcgacttt      840

atcacggagc gcggcgccct ggacgagccg ctggcgcgcc gcttcttcgc gcaggtgctg      900

gccgccgtgc gccactgcca cagctgcggg gtcgtgcacc gcgacattaa ggacgaaaat      960

ctgcttgtgg acctgcgctc cggagagctc aagctcatcg acttcggttc gggtgcgctg     1020

ctcaaggaca cggtctacac cgacttcgac ggcacccgag tgtacagccc cccggagtgg     1080

atccgctacc accgctacca cgggcgctcg gccaccgtgt ggtcgctggg cgtgcttctc     1140

tacgatatgg tgtgtgggga catccccttc gagcaggacg aggagatcct ccgaggccgc     1200

ctgctcttcc ggaggagggt ctctccagag tgccagcagc tgatccggtg gtgcctgtcc     1260

ctgcggccct cagagcggcc gtcgctggat cagattgcgg cccatccctg gatgctgggg     1320

gctgacgggg gcgtcccgga gagctgtgac ctgcggctgt gcaccctcga ccctgatgac     1380

gtggccagca ccacgtccag cagcgagagc ttgtgaggag ctgcacctga ctgggagcta     1440

ggggaccacc tgccttggcc agacctggga cgcccccaga ccctgacttt ctcctgcgtg     1500

ggccgtctcc tcctgcggaa gcagtgacct ctgacccctg gtgaccttcg ctttgagtgc     1560

cttttgaacg ctggtcccgc gggacttggt tttctcaagc tctgtctgtc caaagacgct     1620

ccggtcgagg tcccgcctgc cctgggtgga tacttgaacc ccagacgccc ctctgtgctg     1680

ctgtgtccgg aggcggcctt cccatctgcc tgcccacccg gagctctttc cgccggcgca     1740

gggtcccaag cccacctccc gccctcagtc ctgcggtgtg cgtctgggca cgtcctgcac     1800

acacaatgca agtcctggcc tccgcgcccg cccgcccacg cgagccgtac ccgccgccaa     1860

ctctgttatt tatggtgtga ccccctggag gtgccctcgg cccaccgggg ctatttattg     1920

tttaatttat ttgttgaggt tatttcctct gagcagtctg cctctcccaa gccccagggg     1980

acagtgggga ggcaggggag ggggtggctg tggtccaggg accccaggcc ctgattcctg     2040

tgcctggcgt ctgtcccggc cccgcctgtc agaagatgaa catgtatagt ggctaactta     2100

aggggagtgg gtgaccctga cacttccagg cactgtgccc agggtttggg ttttaaatta     2160

ttgactttgt acagtctgct tgtgggctct gaaagctggg gtggggccag agcctgagcg     2220

tttaatttat tcagtacctg tgtttgtgtg aatgcggtgt gtgcaggcat cgcagatggg     2280

ggttctttca gttcaaaagt gagatgtctg gagatcatat ttttttatac aggtatttca     2340

attaaaatgt ttttgtacat agtggataa                                       2369


<210> 1503
<211> 3111
<212> DNA
<213> Homo sapiens

<400> 1503
gcgagttgtg tgagccgcca gtatggccgg gctatggcgg cgagcactgg ctacgtgcga       60

ctgtggggag cggcgcggtg ctgggtgctg cggcggccga tgctggccgc cgccgggggg      120

cgggttccca ctgcagcagg agcgtggttg ctccgaggcc agcggacctg cgacgcctct      180

cctccttggg cactgtgggg ccgaggcccg gcaattgggg gccaatggcg ggggttttgg      240

gaagcgagca gccgcggcgg aggcgcattc tcggggggcg aggacgcctc cgagggcggc      300

gcggaggaag gagccggcgg cgcggggggc agcgcgggcg ccggggaagg cccggtcata      360

acggcgctca cgcccatgac gatccccgat gtgtttccgc acctgccgct catcgccatc      420

acccgcaacc cggtgttccc gcgctttatc aagattatcg aggttaaaaa taagaagttg      480

gttgagctgc tgagaaggaa agttcgtctc gcccagcctt atgtcggcgt ctttctaaag      540

agagatgaca gcaatgagtc ggatgtggtc gagagcctgg atgaaatcta ccacacgggg      600

acgtttgccc agatccatga gatgcaggac cttggggaca agctgcgcat gatcgtcatg      660

ggacacagaa gagtccatat cagcagacag ctggaggtgg agcccgagga gccggaggcg      720

gagaacaagc acaagccccg caggaagtca aagcggggca agaaggaggc ggaggacgag      780

ctgagcgcca ggcacccggc ggagctggcg atggagccca cccctgagct cccggctgag      840

gtgctcatgg tggaggtaga gaacgttgtc cacgaggact tccaggtcac ggaggaggtg      900

aaagccctga ctgcagagat cgtgaagacc atccgggaca tcattgcctt gaaccctctc      960

tacagggagt cagtgctgca gatgatgcag gctggccagc gggtggtgga caaccccatc     1020

tacctgagcg acatgggcgc cgcgctcacc ggggccgagt cccatgagct gcaggacgtc     1080

ctggaagaga ccaatattcc taagcggctg tacaaggccc tctccctgct gaagaaggaa     1140

tttgaactga gcaagctgca gcagcgcctg gggcgggagg tggaggagaa gatcaagcag     1200

acccaccgta agtacctgct gcaggagcag ctaaagatca tcaagaagga gctgggcctg     1260

gagaaggacg acaaggatgc catcgaggag aagttccggg agcgcctgaa ggagctcgtg     1320

gtccccaagc acgtcatgga tgttgtggac gaggagctga gcaagctggg cctgctggac     1380

aaccactcct cggagttcaa tgtcacccgc aactacctag actggctcac gtccatccct     1440

tggggcaagt acagcaacga gaacctggac ctggcgcggg cacaggcagt gctggaggaa     1500

gaccactacg gcatggagga cgtcaagaaa cgcatcctgg agttcattgc cgttagccag     1560

ctccgcggct ccacccaggg caagatcctc tgcttctatg gcccccctgg cgtgggtaag     1620

accagcattg ctcgctccat cgcccgcgcc ctgaaccgag agtacttccg cttcagcgtc     1680

gggggcatga ctgacgtggc tgagatcaag ggccacaggc ggacctacgt gggcgccatg     1740

cccgggaaga tcatccagtg tttgaagaag accaagacgg agaaccccct gatcctcatc     1800

gacgaggtgg acaagatcgg ccgaggctac cagggggacc cgtcgtcggc actgctggag     1860

ctgctggacc cagagcagaa tgccaacttc ctggaccact acctggacgt gcccgtggac     1920

ttgtccaagg tgctgttcat ctgcacggcc aacgtcacgg acaccatccc cgagccgctg     1980

cgagaccgta tggagatgat caacgtgtcg ggctacgtgg cccaggagaa gctggccatt     2040

gcggagcgct acctggtgcc ccaggctcgc gccctgtgtg gcttggatga gagcaaggcc     2100

aagctgtcat cggacgtgct gacgctgctc atcaagcagt actgccgcga gagcggtgtc     2160

cgcaacctgc agaagcaagt ggagaaggtg ttacggaaat cggcctacaa gattgtcagc     2220

ggcgaggccg agtccgtgga ggtgacgccc gagaacctgc aggacttcgt ggggaagccc     2280

gtgttcaccg tggagcgcat gtatgacgtg acaccgcccg gcgtggtcat ggggctggcc     2340

tggaccgcaa tgggaggctc cacgctgttt gtggagacat ccctgagacg gccacaggac     2400

aaggatgcca agggtgacaa ggatggcagc ctggaggtga caggccagct gggggaggtg     2460

atgaaggaga gcgcccgcat agcctacacc ttcgccagag ccttcctcat gcagcacgcc     2520

cccgccaatg actacctggt gacctcacac atccacctgc atgtgcccga gggcgccacc     2580

cccaaggacg gcccaagcgc aggctgcacc atcgtcacgg ccctgctgtc cctggccatg     2640

ggcaggcctg tccggcagaa tctggccatg actggcgaag tctccctcac gggcaagatc     2700

ctgcctgttg gtggcatcaa ggagaagacc attgcggcca agcgcgcagg ggtgacgtgc     2760

atcgtcctgc cagccgagaa caagaaggac ttctacgacc tggcagcctt catcaccgag     2820

ggcctggagg tgcacttcgt ggaacactac cgggagatct tcgacatcgc cttcccggac     2880

gagcaggcag aggcgctggc cgtggaacgg tgacggccac cccgggactg caggcggcgg     2940

atgtcaggcc ctgtctgggc cagaactgag cgctgtgggg agcgcgcccg gacctggcag     3000

tggagccacc gagcgagcag ctcggtccag tgacccagat cccagggacc tcagtcggct     3060

taatcagagt gtggcataga agctatttaa tgattaaagt catttgcagt a              3111


<210> 1504
<211> 2103
<212> DNA
<213> Homo sapiens

<400> 1504
ataattcaac agctcaactt tcgggcccgc ctctttcctg ggggtgggag tttgctccaa       60

actttgttta tgggacagtc cgggagctgc tgcggccgcg ctgtctgctt ctcctgcgcc      120

tccttttcgc ccagcactag cgccttaggc cagctcgggg gatgtgagag ccgaagccct      180

tagactgcca ggcacagagt cgggtcggga tttgtcagcc aagcctcggc tccagctccg      240

caatctcggg actcacccga gcgacccagg cccgacggca agttcgggcg ggacggcggc      300

cgccgcgcgc tcaggctcag cttcgctgcc cgcccagaag atgaatccgg cctcggcgcc      360

ccctccgctc ccgccgcctg ggcagcaagt gatccacgtc acgcaggacc tagacacaga      420

cctcgaagcc ctcttcaact ctgtcatgaa tccgaagcct agctcgtggc ggaagaagat      480

cctgccggag tctttcttta aggagcctga ttcgggctcg cactcgcgcc agtccagcac      540

cgactcgtcg ggcggccacc cggggcctcg actggctggg ggtgcccagc atgtccgctc      600

gcactcgtcg cccgcgtccc tgcagctggg caccggcgcg ggtgctgcgg gtagccccgc      660

gcagcagcac gcgcacctcc gccagcagtc ctacgacgtg accgacgagc tgccactgcc      720

cccgggctgg gagatgacct tcacggccac tggccagagg tacttcctca atcacataga      780

aaaaatcacc acatggcaag accctaggaa ggcgatgaat cagcctctga atcatatgaa      840

cctccaccct gccgtcagtt ccacaccagt gcctcagagg tccatggcag tatcccagcc      900

aaatctcgtg atgaatcacc aacaccagca gcagatggcc cccagtaccc tgagccagca      960

gaaccacccc actcagaacc cacccgcagg gctcatgagt atgcccaatg cgctgaccac     1020

tcagcagcag cagcagcaga aactgcggct tcagagaatc cagatggaga gagaaaggat     1080

tcgaatgcgc caagaggagc tcatgaggca ggaagctgcc ctctgtcgac agctccccat     1140

ggaagctgag actcttgccc cagttcaggc tgctgtcaac ccacccacga tgaccccaga     1200

catgagatcc atcactaata atagctcaga tcctttcctc aatggagggc catatcattc     1260

gagggagcag agcactgaca gtggcctggg gttagggtgc tacagtgtcc ccacaactcc     1320

ggaggacttc ctcagcaatg tggatgagat ggatacagga gaaaacgcag gacaaacacc     1380

catgaacatc aatccccaac agacccgttt ccctgatttc cttgactgtc ttccaggaac     1440

aaacgttgac ttaggaactt tggaatctga agacctgatc cccctcttca atgatgtaga     1500

gtctgctctg aacaaaagtg agccctttct aacctggctg taatcactac cattgtaact     1560

tggatgtagc catgacctta catttcctgg gcctcttgga aaaagtgatg gagcagagca     1620

agtctgcagg tgcaccactt cccgcctcca tgactcgtgc tccctccttt ttatgttgcc     1680

agtttaatca ttgcctggtt ttgattgaga gtaacttaag ttaaacataa ataaatattc     1740

tattttcatt ttctgcaagc ctgcgttctt gtgacagatt atacagaatt gtgtctgcag     1800

gattgattat gcagaatact tttctctttc ttctctgctg ccccatggct aagctttatg     1860

ggtgttaatt gaaatttata caccaattga ttttaaacca taaaaagctg accacaggca     1920

gttacttctg agggcatctt ggtccaggaa atgtgcacaa aattcgacct gatttacagt     1980

ttcaaaaact gtattgatga cagtagtacc aaatgcttta aaaactattt aacttgagct     2040

ttaaaaatca ttgtatggat agtaaaattc tactgtatgg aatacaatgt aattttgaat     2100

cca                                                                   2103


<210> 1505
<211> 3031
<212> DNA
<213> Homo sapiens

<400> 1505
atggagatgg ctaacagcta gagcaggctg tcctcggagg gaaccgggtc acatcgcagg       60

gccacctcta gctgcaagag aatctgggaa gctgagcaat tcaaaccagg cacactgctg      120

ccccccacac aactggggtt ctgccgtata gaagaggaga ctggatcttt ggagacattc      180

catctccaga cacccagaga cgctccagaa tggaggtcct gagggagaag gtggaggagg      240

aggaggaggc cgagcgggag gaggcggccg agtgggctga atgggcgagg atggagaaaa      300

tgatgaggcc agttgaggtg cggaaggagg aaatcacctt aaagcaggag acgctcagag      360

acctggagaa gaagctgtca gagatccaga tcactgtctc agcggagctc ccggccttta      420

ccaaggacac tattgacatc tccaagctgc ccatttccta caaaaccaac acacccaagg      480

aggaacacct gctgcaggtg gcagacaact tctcccgcca gtacagccat ctgtgcccgg      540

accgcgtgcc cctcttcctg caccccctga acgagtgtga agtgcccaag ttcgtgagca      600

caaccctccg gcccacactg atgccctacc ccgagctcta caactgggac agctgtgccc      660

agtttgtctc cgacttcctc accatggtgc ccctgcctga ccctctcaag ccgccctcgc      720

acctgtactc ctcgaccact gtgctcaagt accagaaggg gaactgcttt gacttcagta      780

cgctgctctg ctccatgctt atcggctctg gctatgatgc ttactgcgtc aacggctacg      840

gctcgctgga cctgtgccac atggacctga cgcgggaggt gtgcccactc actgtgaagc      900

ccaaggagac catcaagaag gaggaaaagg tgctgcctaa gaagtatacc atcaaacccc      960

ccagggacct gtgcagcagg tttgagcagg agcaagaggt gaagaagcag caggagatca     1020

gagcccagga gaagaagcgg ctgagggagg aggaggagcg cctcatggaa gcggagaagg     1080

caaagccgga tgccctgcac ggcctgcggg tgcactcctg ggtccttgtg ctatcgggga     1140

agcgcgaggt gcctgagaac ttcttcatcg acccattcac aggacatagc tacagcaccc     1200

aggatgagca cttcctgggc atcgaaagcc tgtggaacca caagaactac tggatcaaca     1260

tgcaggattg ctggaactgc tgcaaggact tgatctttga cctgggtgac cctgtgagat     1320

gggagtacat gctcctgggg actgataagt ctcagctgtc cttgactgaa gaagacgaca     1380

gtgggataaa cgatgaggat gatgtggaaa atctgggcaa ggaggatgag gataagagct     1440

tcgacatgcc ccactcgtgg gtggagcaga ttgagatctc cccggaagca tttgagaccc     1500

gctgcccgaa cgggaagaag gtgattcagt acaagagggc aaagctggag aagtgggccc     1560

cgtacctcaa tagcaatggc cttgtgagcc gcctcaccac ctatgaggac ttgcagtgta     1620

ccaatatttt ggagataaag gagtggtacc agaaccggga agacatgctg gagctgaaac     1680

acataaacaa gaccacagac ctgaagacag actacttcaa gcctggccac ccccaggctc     1740

tgcgcgtgca ctcgtacaag tccatgcaac ctgagatgga ccgtgtcatt gagttttatg     1800

aaacggcccg tgtggatggc ctgatgaagc gggaggagac acccaggaca atgacagagt     1860

actatcaagg acgcccagac ttcctctcct accgccatgc cagcttcgga ccccgagtca     1920

agaagctcac tctgagcagt gcagagtcaa acccccggcc cattgtgaaa atcacagagc     1980

ggttcttccg caacccagcg aagcccgcgg aggaggacgt ggcagagcgc gtgtttctgg     2040

tcgcggagga gcgcatccag ctgcgctacc actgccgtga ggaccacatc acggcctcca     2100

agcgcgagtt cctgcggcgc accgaggtgg acagcaaagg caacaagatc atcatgacgc     2160

ccgacatgtg catcagcttc gaggtggagc ccatggagca caccaagaag ctgctctacc     2220

agtacgaggc catgatgcac ctgaagaggg aggagaagct gtccagacat caggtctggg     2280

agtcagagct ggaggtgctg gagattctga agcttcgaga ggaagaggag gcggcgcaca     2340

cactgaccat ctccatctat gacaccaagc ggaatgagaa gagcaaggaa tatcgggagg     2400

ccatggagcg catgatgcac gaagagcacc tgcggcaggt ggagacccag ctggactacc     2460

tggccccatt cctggcccag ctcccgccag gagagaaact aacatgctgg caggcggtgc     2520

gcctcaagga tgagtgcctc agcgacttca agcagcggct catcaacaag gccaacctca     2580

tccaggcccg ctttgagaag gagacccagg agctgcaaaa gaagcagcag tggtaccagg     2640

agaaccaggt gacgctgaca cccgaggatg aagacctgta cctgagttac tgctctcagg     2700

ccatgttccg catccgcatc ctggagcagc gcctcaatcg acacaaggaa ctggccccac     2760

tgaagtacct ggctctggag gaaaagctct acaaggaccc acgcctgggg gagctccaga     2820

aaatattcgc ttgatgtccc tcctggggcc tcagccagag ctgccagaga aaggaaacct     2880

cttcccgcag cctggctcct gtgttccctc tatccagcca atgcctgttt acacagacac     2940

ctggcctcac tgccagccca cctcccctac agccctgttt gttcctgctt ctcatgattt     3000

tcctgtaaat aaacacactc ttaatttgcc a                                    3031


<210> 1506
<211> 2686
<212> DNA
<213> Homo sapiens

<400> 1506
gtctttagct ctcatggatt gggagctggg aaaggaatga gaagacagaa gtcagagaca       60

agaagaggct aacatgactg ataccactat aatttagtgg atcagtgtct ttcaatgatg      120

tgactgtgga cttcactcag gaggagtggc agcacctgga tcatgctcag aagactctat      180

atatggatgt gatgttggaa aactattgcc acctcatctc tgtggggtgt cacatgacca      240

aacctgatgt gatcctcaag ttggaacgag gagaagagcc atggacatca tttgcaggtc      300

atacctgctt ggaagaaaac tggaaagctg aagacttttt agtgaaattc aaggaacacc      360

aagagaagta ttctagatca gttgtaagca tcaaccacaa aaaactggtg aaggagaaga      420

gtaaaatata tgaaaagaca tttactctag gcaaaaaccc tgtgaattca aaaaatctac      480

ctcctgaata tgatactcat ggaaggattt tgaaaaatgt ttcagaatta atcatcagta      540

atctaaatcc tgcaagaaag agacttagtg agtataatgg atatgggaaa tcactcctga      600

gtactaaaca agagactact catcctgaag tcaaatccca taatcaaagt gccagagctt      660

tcagtcataa tgaagttctt atgcagtatc agaaaacgga aactccagca cagtcatttg      720

gatataatga ctgtgagaaa tcattccttc aaaggggagg cctgattaca catagtagac      780

cttacaaagg agaaaaccca tctgtatata ataaaaaaag aagagcaacc aatattgaaa      840

aaaaacatac atgcaatgaa tgtgggaaat ctttctgcag gaaatcagta ttgattctgc      900

atcagggaat tcactcagaa gaaaaaccct atcaatgtca tcaatgtgga aatgcattta      960

gaaggaaatc atatctcatt gatcatcaga gaactcacac aggagagaaa ccctttgttt     1020

gcaatgaatg tggtaagtcc ttccgcctca agacagccct cactgatcat cagagaacac     1080

acacagggga gaaatcgtat gaatgtctgc aatgtaggaa tgccttcaga ttgaagtcac     1140

acctcattcg tcatcagaga actcacacgg gagagaaacc atatgagtgt aatgactgtg     1200

ggaagtcctt ccgccagaag acaacactct ctctacatca gagaatccat acaggtgaga     1260

aaccctacat ttgtaaagaa tgtgggaagt cctttcacca gaaggcaaat cttactgtac     1320

atcagagaac tcatacaggg gaaaagccct atatttgtaa tgaatgtggg aaatccttct     1380

cccagaagac aacccttgct cttcatgaga aaactcataa tgaggagaaa ccctatattt     1440

gtagtgaatg tggaaagtcc ttccgccaga agacaaccct tgtagcacat cagagaacac     1500

atacagggga gaaatcttat gaatgtcctc actgtgggaa ggcctttaga atgaagtcat     1560

acctcattga tcatcaccga actcacacag gagagaaacc atatgaatgt aatgaatgtg     1620

gtaaatcatt cagtcaaaag acaaatctca atctacatca gagaattcat acaggggaga     1680

aaccctatgt ttgtaatgaa tgtgggaagt cctttcgcca gaaagcaacc ctcactgtac     1740

atcagaaaat acataccggc cagaaatcct atgaatgtcc tcagtgtggg aaagccttta     1800

gcaggaagtc atatctcatt catcatcaaa gaactcatac gggagagaaa ccatataaat     1860

gtagtgaatg tggaaagtgc ttccgccaga agacaaatct tattgtacat cagagaactc     1920

acacaggtga gaaaccctat gtttgtaatg agtgtggtaa gtctttcagt tataagagaa     1980

acctcattgt ccatcaaaga actcacaagg gagaaaacat tgaaatgcaa taaatgatgt     2040

ggtttcttat atgaattctt tacaagctgt tgtaaacatt tagttttaaa aagaaaagca     2100

tgctgaaaca tgttaatgta attttaaatc acaagtctaa taattattaa agtaccatac     2160

ggaataactg tctactgttt actagcatat aaaataagta tgatcattat tattgaactc     2220

tatcagctat gaagctaaat tttaaagtca actgctcttc ctactgactc aaatagttta     2280

ttttttaaaa atacttatat aatacatgca gagacaagat acacaatgat tataagtatt     2340

aatctccata agagaaaata tttatgaact atatttctca ttgcactctg taataaaaag     2400

cagttagttg ttacttacct aagagttacc acttccgtag cctataacat caaaacgtag     2460

tttttgcatg ttttcaattt tataaatata tattttatca gacatcatga attattttgt     2520

gtcttgctta tttcactcaa ttttttaaga tctgtacatt attgcatgtg gcagtagtgt     2580

attttcattt tgcatactat tccattttaa gaatatattg ctgtttatcc tattgatgga     2640

tatttgtatt ttttatactt ttgtgtaata ataaaaatac tgctgt                    2686


<210> 1507
<211> 739
<212> DNA
<213> Homo sapiens

<400> 1507
tcactgccct ctgcctcgac cttatccagc cacacgccac catgtgtcat accagctgct       60

cctcgggctg ccagccagcc tgctgcgcgc ccagcccctg ccagccagcc tgttgtgtgc      120

ccagctcctg ccaggcatcc tgctgtgtgc ctgtgggctg ccagtcctcc gtgtgtgtgc      180

ccgtgagctt caagccagcc gtgtgcctgc ccgtgagctg ccagtcttct gtgtgtgtgc      240

ccatgagctt caagtcagct gtgtgcgtgc ccgtgagctg ccagtcttct gtgtgtgtgc      300

ctgtgagctg caggcccatt gtgtgtgcag ccccctcctg ccagtcctcc ctgtgcgtgc      360

ctgtgagctg caggcctgtc gtgtatgcgg ctccgtcctg ccagtcctct gggtgctgcc      420

agccctcctg caccagcgtc ctctgcagac ccatctccta cagtatctct tcctgctgct      480

gagcatgaat ctccagaccc gctgctccca gtgcagatga ggccacacct gtacactccc      540

tggatgagtc ctcagttggt cttctgcaca tggtgcaggt gaaaagcatg ctcagttgaa      600

ccctctgaat tctggattga gaatgtgaca gaatgatctg gagcccttgc tgaccttgcc      660

catcccccca gggaagtctg gggtcccaga gtcattctct gaccccatga gagccaaata      720

aaccagcttt ccccatgca                                                   739


<210> 1508
<211> 1305
<212> DNA
<213> Homo sapiens

<400> 1508
gttgaggtca agtagtagcg ttgggctgcg gcagcggagg agctcaacat gcgtgagtgt       60

atctctatcc acgtggggca ggcaggagtc cagatcggca atgcctgctg ggaactgtac      120

tgcctggaac atggaattca gcccgatggt cagatgccaa gtgataaaac cattggtggt      180

ggggacgact ccttcaacac gttcttcagt gagactggag ctggcaagca cgtgcccaga      240

gcagtgtttg tggacctgga gcccactgtg gtcgatgaag tgcgcacagg aacctatagg      300

cagctcttcc acccagagca gctgatcacc gggaaggaag atgcggccaa taattacgcc      360

agaggccatt acaccatcgg caaggagatc gtcgacctgg tcctggaccg gatccgcaaa      420

ctggcggatc tgtgcacggg actgcagggc ttcctcatct tccacagttt tgggggtggc      480

actggctctg ggttcgcatc tctgctcatg gagcggctct cagtggatta cggcaagaag      540

tccaagctag aatttgccat ttacccagcc ccccaggtct ccacggccgt ggtggagccc      600

tacaactcca tcctgaccac ccacacgacc ctggaacatt ctgactgtgc cttcatggtc      660

gacaatgaag ccatctatga catatgtcgg cgcaacctgg acatcgagcg tcccacgtac      720

accaacctca atcgcctgat tgggcagatc gtgtcctcca tcacggcctc cctgcgattt      780

gacggggccc tgaatgtgga cttgacggaa ttccagacca acctagtgcc gtacccccgc      840

atccacttcc ccctggccac ctacgccccg gtcatctcag ccgagaaggc ctaccacgag      900

cagctgtccg tggctgagat caccaatgcc tgcttcgagc cagccaatca gatggtcaag      960

tgtgaccctc gccacggcaa gtacatggcc tgctgcatgt tgtacagggg ggatgtggtc     1020

ccgaaagatg tcaacgcggc catcgccacc atcaagacca agcgcaccat ccagtttgta     1080

gattggtgcc caactggatt taaggtgggc attaactacc agccccccac ggtggtccct     1140

gggggagacc tggccaaggt gcagcgggct gtgtgcatgc tgagcaacac cacggccatc     1200

gcggaggcct gggctcgcct ggacctggca gctctggaga aggattatga agaggtgggc     1260

gtggattccg tggaagccga ggctgaagaa ggtgaagaat actga                     1305


<210> 1509
<211> 5740
<212> DNA
<213> Homo sapiens

<400> 1509
gattggacag ctggggacct tcttctgatt aaccttaaac caacttgtag ccatagagac       60

acctcacaag gttcccattt ttgttgttgt tgttgttgat tttctgctca cacctttcct      120

gaccttgcaa ccatgtatgg aagtgcccgc tctgttggga aggtggagcc gagcagccag      180

agccctgggc gttcacccag gcttccacgt tcccctcgct tgggtcaccg tcgaaccaac      240

agtacgggag ggagttcggg aagcagtgtt ggaggtggca gtgggaaaac cctttcaatg      300

gaaaatatac aatctttaaa tgctgcctat gccacctctg gccctatgta tctaagtgac      360

catgaaaatg tgggttcaga aacacctaaa agcaccatga cacttggccg ttctggggga      420

cgtctgcctt acggtgttcg gatgactgct atgggtagta gccccaatat agctagcagt      480

ggggttgcta gtgacaccat agcatttgga gagcatcacc tccctcctgt gagtatggca      540

tccactgtac ctcactccct tcgtcaggcg agagataaca caatcatgga tctgcagaca      600

cagctgaagg aagtattaag agaaaatgat ctcttgcgga aggatgtgga agtaaaggag      660

agcaaattga gttcttcaat gaatagcatc aagaccttct ggagcccaga gctgaagaag      720

gaacgagccc tgagaaaaga tgaagcttcc aaaatcacca tttggaagga acagtacaga      780

gttgtacagg aggaaaacca gcacatgcag atgacaatcc aggctctcca ggatgaattg      840

cggatccaga gggacctgaa tcagctgttt cagcaggata gtagcagcag gactggcgaa      900

ccttgtgtag cagagctgac agaggagaac tttcagaggc ttcatgctga gcatgagcgg      960

caggccaaag agctgtttct tcttcgaaag acattggagg aaatggagct gcgtattgag     1020

actcaaaagc agaccctaaa tgctcgggat gaatccatta agaagcttct ggaaatgttg     1080

cagagcaaag gactttctgc caaggctacc gaggaagacc atgagagaac aagacgactg     1140

gcagaggcag agatgcacgt tcatcaccta gaaagccttt tggagcagaa ggaaaaagag     1200

aacagtatgt tgagagagga gatgcatcga aggtttgaga atgctcctga ttctgccaaa     1260

acaaaagctc tgcaaactgt tattgagatg aaggattcaa aaatttcctc tatggagcgt     1320

gggcttcgag acctggaaga ggaaattcag atgctgaaat cgaatggtgc tttgagtact     1380

gaggaaaggg aagaagaaat gaagcaaatg gaagtgtatc ggagccattc taaatttatg     1440

aaaaataagg tagaacaact gaaggaggaa ctaagttcga aagaggctca atgggaggag     1500

ctgaaaaaga aagcggctgg tcttcaggct gagattggcc aggtgaaaca ggagctgtcc     1560

agaaaggaca cagaactact cgccctgcag acaaagctag aaacactcac aaaccagttc     1620

tcagatagta aacagcacat tgaagtgttg aaggagtcct tgactgctaa ggagcagagg     1680

gctgccatcc tgcagactga ggtggatgct ctccgattgc gtttggaaga gaaggaaacc     1740

atgttgaata aaaagacaaa acaaattcag gatatggctg aagagaaggg gacacaagct     1800

ggagagatac atgacctcaa ggacatgttg gatgtgaagg agcggaaggt taatgttctt     1860

cagaagaaga ttgaaaatct tcaagagcag cttagagaca aggaaaagca gatgagcagc     1920

ttgaaagaac gggtcaaatc cttgcaggct gacaccacca acactgacac tgccttgaca     1980

actttggagg aggcccttgc agagaaagag cggacaattg aacgcttaaa ggagcagagg     2040

gacagagatg agcgagagaa gcaagaggaa attgataact acaaaaaaga tcttaaagac     2100

ttgaaggaaa aagtcagcct gttgcaaggc gacctttcag agaaagaggc ttcacttttg     2160

gatctgaaag agcatgcttc ttctctggca tcctcaggac tgaaaaagga ctcacggctt     2220

aagacactag agattgcttt ggagcagaag aaggaggagt gtctgaaaat ggaatcacaa     2280

ttgaaaaagg cacatgaggc agcattggaa gccagagcca gtccagagat gagtgaccga     2340

atacagcact tggagagaga gatcaccagg tacaaagatg aatctagcaa ggcccaggca     2400

gaagttgatc gactcttaga aatcttgaag gaggtggaaa atgagaagaa tgacaaagat     2460

aagaagatag ctgagttgga aaggcaagtg aaagaccaga ataagaaggt agcaaatctg     2520

aagcacaagg aacaggtgga aaaaaagaag agtgcacaaa tgttagagga ggcgcgacga     2580

cgggaggaca atctcaacga cagctctcag cagctacagg acagtctccg taagaaggat     2640

gacaggattg aagagctgga agaagcacta agagaaagtg tacagataac tgcagagcgg     2700

gaaatggtgc tagcacaaga ggaatcagcc aggaccaatg ctgaaaaaca ggtggaggag     2760

ttactgatgg ccatggagaa ggtaaagcag gaactagaat ccatgaaagc aaagctgtcc     2820

tccacccagc agtctctggc agaaaaggaa actcacttga ctaatcttcg ggcagagaga     2880

aggaaacact tagaggaagt tctggagatg aagcaagaag ctcttctggc tgccattagt     2940

gaaaaagacg ccaatatagc tctcttggag ctttcgtcct ctaagaagaa gacccaagag     3000

gaagtggctg ccctgaagcg ggagaaggat cgtctggtac agcagcttaa gcagcagacg     3060

caaaatcgaa tgaagctaat ggccgacaac tacgaggatg accacttcaa atcctcccat     3120

tccaatcaaa caaatcacaa gccctcccca gaccagatca tccagcccct cttagaactt     3180

gaccaaaata gaagtaaatt aaagttgtac attggacacc tgacaaccct ctgccatgac     3240

cgagaccccc tgatcctccg tggactcact ccaccagctt cctataactt ggacgatgac     3300

caggcggctt gggagaatga gctgcagaag atgacccggg ggcagcttca ggatgagtta     3360

gagaaaggtg aacgggacaa tgcagaactg caggagtttg ccaacgccat tcttcagcag     3420

atagcagacc attgtcccga catcctagag caagtggtca acgccctgga agagtcctct     3480

tgaccctgct ttatggggaa gcctgaggta gtcaacccag gagccaagaa aagagaacta     3540

cgaggaacag gtgcccggaa ccttcttggc accaaacact acaaacttca tcccaacttg     3600

ctcacttgaa gaagtgtgat tccagcaccg tttctacatc tgccatctta ctctgccttt     3660

ctgctttgga tgtggtctct acactaacct tcttgatgtc cagggtagat aaagggtcga     3720

atctctctga agaactgcca cctggtcatc agcagtggag aactgtggga gctggtggct     3780

ctgccctgac agagagccat ggagcagagg agcctctcac ctcctgtcct ctgacatgag     3840

aatgaaacca ggaatggact tggagttcaa caggctgaga ggatgcctcc aatggaccag     3900

agagctgagt gttctaatat cacaataggt gctttctcct aaaagggcaa aaaacaatct     3960

caaaaagatt agaaaaagag aaggggggaa gggaagagaa aatcgactct tctttttact     4020

gtctcttctg cttactttcc acatgagatg ctttgtaccg gggagctgtg agcaggcctc     4080

acgatggctt gggagcactc gttctcccaa ggtctgagtc ttcatccagc cctgcctgtc     4140

tgtcgcagcc ttcctcactc tgttcctcgg ccagttaaca agaagatggt gtgaggtgtt     4200

ctccaccagt ctctcctgtt tgagactgtt gacgttatca tactgaggtg ttagatcaaa     4260

tatctctaat tgaagaacat gtgaggttga aagagcacca gccagggcaa catagcgtga     4320

ccctgtctct acaaaaaatt aaaaagagaa catacaaagt tgacatatga gaccctgttg     4380

tccccgcctg cagctttgcc ccagtaacag atgcccgttg ctcttgggct ggtttcccct     4440

gaacacctcc aagaggctgc ctgccttgcc agcacccgtg tcctgagctc ctgcagccca     4500

gtggctgctg aagttgtgat ccctcactca ccctgctagc tttgcccttg actcgtcttc     4560

tctgaacctc agcctcgtgc attgcctgga accttcttct agcataaatg aaggtttttc     4620

ctcctacaca cattccttcc tcggttattt cattcagaga atatttatga aatgcctact     4680

gtgtgcaagt catccatcct tgaaaaggcc acttctcagt gagggagaga tgtagtggat     4740

tctgtgagac atacctgctg gagttgaagc agtaaatagc atgtccttcc cctccccgat     4800

cttaaggtgt gttttctaga aaagttccct aatggaattc atgagtttgg gggtctcagt     4860

cacccgcttg cctgtaggat tccatttgat gattctggat ttttgctgtt tgttattgcc     4920

cttagagggg ctctgagtat ctacttgtgg gtggccattt cctgacatct gcatgtacct     4980

cgtggaattc agccagcttc atgttgcaaa tcagaaagct gaccccaaga ctgcaaatca     5040

atgaaggtat tggcattgtt aaggacgtag cgtagacaac agcagtcata aataattagg     5100

caggaactta acccaaatct agttctttga ccacctctac caccagaacc cagcagacac     5160

tcacatctcc tgataagagt tgctggactc gatgtttttg ttttgcattt tctcctctcc     5220

ttccccactt actcagagaa tttaaagtct gtagagtcag cacagcccca tcagtccagg     5280

aacttcccac caccagccct tgactgtccc attaactgac atggtcagat ttccagctcc     5340

ccctactccc tgctgtgaaa caatccctct ccctgtgaga ggaaactgtg gagcgtttct     5400

tatcgaaggt taaatggact ctgctcataa acctcttact gagatgcttc ctgatagcca     5460

ggctggccag agaggggtgc aggggttaga tagtaagtgg tggtcgtttg tggtcagtta     5520

cctcaattct gttcattgca gtgcccgtaa accatgtaga aagctcccag cactgaaagg     5580

caggagtgtt agcatctcgc tttatccacc ataacgtaaa gaactgcggt gtgataacag     5640

ccttcacggg gccacggtgg aaccaagaca gcaggcgagg ccatgcctaa acaagtggtc     5700

tggcacgggc actggccagc tgctctctcc aagcaggtgg                           5740


<210> 1510
<211> 3359
<212> DNA
<213> Homo sapiens

<400> 1510
tgtttatact ccggagggtg tccccgtgcg tcatcggtgg agtggaccaa aactggtgat       60

ctgtttgccc tgtgtgacct tgcccagaac cctgctgact gagagaacac atctgctgga      120

agtcctctgg gattcaaggt acagggaatg aagagtagtt ttacagaaaa aagaggacaa      180

tattgggatc acctttgacc tttccatttg gaaataatat tttctattgt gttatagaaa      240

ggtgggaagc tttcatccag aacaatgaat ttcataaagg acaatagccg agcccttatt      300

caaagaatgg gaatgactgt tataaagcaa atcacagatg acctatttgt atggaatgtt      360

ctgaatcgcg aagaagtaaa catcatttgc tgcgagaagg tggagcagga tgctgctaga      420

gggatcattc acatgatttt gaaaaagggt tcagagtcct gtaacctctt tcttaaatcc      480

cttaaggagt ggaactatcc tctatttcag gacttgaatg gacaaagtct ttttcatcag      540

acatcagaag gagacttgga cgatttggct caggatttaa aggacttgta ccatacccca      600

tcttttctga acttttatcc ccttggtgaa gatattgaca ttatttttaa cttgaaaagc      660

accttcacag aacctgtcct gtggaggaag gaccaacacc atcaccgcgt ggagcagctg      720

accctgaatg gcctcctgca ggctcttcag agcccctgca tcattgaagg ggaatctggc      780

aaaggcaagt ccactctgct gcagcgaatt gccatgctct ggggctccgg aaagtgcaag      840

gctctgacca agttcaaatt cgtcttcttc ctccgtctca gcagggccca gggtggactt      900

tttgaaaccc tctgtgatca actcctggat atacctggca caatcaggaa gcagacattc      960

atggccatgc tgctgaagct gcggcagagg gttcttttcc ttcttgatgg ctacaatgaa     1020

ttcaagcccc agaactgccc agaaatcgaa gccctgataa aggaaaacca ccgcttcaag     1080

aacatggtca tcgtcaccac taccactgag tgcctgaggc acatacggca gtttggtgcc     1140

ctgactgctg aggtggggga tatgacagaa gacagcgccc aggctctcat ccgagaagtg     1200

ctgatcaagg agcttgctga aggcttgttg ctccaaattc agaaatccag gtgcttgagg     1260

aatctcatga agacccctct ctttgtggtc atcacttgtg caatccagat gggtgaaagt     1320

gagttccact ctcacacaca aacaacgctg ttccatacct tctatgatct gttgatacag     1380

aaaaacaaac acaaacataa aggtgtggct gcaagtgact tcattcggag cctggaccac     1440

tgtggagacc tagctctgga gggtgtgttc tcccacaagt ttgatttcga actgcaggat     1500

gtgtccagcg tgaatgagga tgtcctgctg acaactgggc tcctctgtaa atatacagct     1560

caaaggttca agccaaagta taaattcttt cacaagtcat tccaggagta cacagcagga     1620

cgaagactca gcagtttatt gacgtctcat gagccagagg aggtgaccaa ggggaatggt     1680

tacttgcaga aaatggtttc catttcggac attacatcca cttatagcag cctgctccgg     1740

tacacctgtg ggtcatctgt ggaagccacc agggctgtta tgaagcacct cgcagcagtg     1800

tatcaacacg gctgccttct cggactttcc atcgccaaga ggcctctctg gagacaggaa     1860

tctttgcaaa gtgtgaaaaa caccactgag caagaaattc tgaaagccat aaacatcaat     1920

tcctttgtag agtgtggcat ccatttatat caagagagta catccaaatc agccctgagc     1980

caagaatttg aagctttctt tcaaggtaaa agcttatata tcaactcagg gaacatcccc     2040

gattacttat ttgacttctt tgaacatttg cccaattgtg caagtgccct ggacttcatt     2100

aaactggact tttatggggg agctatggct tcatgggaaa aggctgcaga agacacaggt     2160

ggaatccaca tggaagaggc cccagaaacc tacattccca gcagggctgt atctttgttc     2220

ttcaactgga agcaggaatt caggactctg gaggtcacac tccgggattt cagcaagttg     2280

aataagcaag atatcagata tctggggaaa atattcagct ctgccacaag cctcaggctg     2340

caaataaaga gatgtgctgg tgtggctgga agcctcagtt tggtcctcag cacctgtaag     2400

aacatttatt ctctcatggt ggaagccagt cccctcacca tagaagatga gaggcacatc     2460

acatctgtaa caaacctgaa aaccttgagt attcatgacc tacagaatca acggctgccg     2520

ggtggtctga ctgacagctt gggtaacttg aagaacctta caaagctcat aatggataac     2580

ataaagatga atgaagaaga tgctataaaa ctagctgaag gcctgaaaaa cctgaagaag     2640

atgtgtttat ttcatttgac ccacttgtct gacattggag agggaatgga ttacatagtc     2700

aagtctctgt caagtgaacc ctgtgacctt gaagaaattc aattagtctc ctgctgcttg     2760

tctgcaaatg cagtgaaaat cctagctcag aatcttcaca atttggtcaa actgagcatt     2820

cttgatttat cagaaaatta cctggaaaaa gatggaaatg aagctcttca tgaactgatc     2880

gacaggatga acgtgctaga acagctcacc gcactgatgc tgccctgggg ctgtgacgtg     2940

caaggcagcc tgagcagcct gttgaaacat ttggaggagg tcccacaact cgtcaagctt     3000

gggttgaaaa actggagact cacagataca gagattagaa ttttaggtgc attttttgga     3060

aagaaccctc tgaaaaactt ccagcagttg aatttggcgg gaaatcgtgt gagcagtgat     3120

ggatggcttg ccttcatggg tgtatttgag aatcttaagc aattagtgtt ttttgacttt     3180

agtactaaag aatttctacc tgatccagca ttagtcagaa aacttagcca agtgttatcc     3240

aagttaactt ttctgcaaga agctaggctt gttgggtggc aatttgatga tgatgatctc     3300

agtgttatta caggtgcttt taaactagta actgcttaaa taaagtgtac tcgaagcca      3359


<210> 1511
<211> 3122
<212> DNA
<213> Homo sapiens

<400> 1511
agcaccgtct gggctgtgga agcggagggg gtggggacac tctggcccgg ttctcggtgg       60

tgcgggagcg ggcgggagca gcggccgctc tggtcggcgg acgtgctgcc gagtagtccc      120

ggaagcgaag cagcgatggc ggagagtccg actgaggagg cggcaacggc gggcgccggg      180

gcggcgggcc ccggggcgag cagcgttgct ggtgttgttg gcgttagcgg cagcggcggc      240

gggttcgggc cgcctttcct gccggatgtg tgggcggcgg cggcggcagc gggcggggcc      300

gggggcccgg ggagcggcct ggctccgctg cccgggctcc cgccctcagc cgctgcccac      360

ggggccgcgc tgcttagcca ctgggacccc acgctcagct ccgactggga cggcgagcgc      420

accgcgccgc agtgtctact ccggatcaag cgggatatca tgtccattta taaggagcct      480

cctccaggaa tgttcgttgt acctgatact gttgacatga ctaagattca tgcattgatc      540

acaggcccat ttgacactcc ttatgaaggg ggtttcttcc tgttcgtgtt tcggtgtccg      600

cccgactatc ccatccaccc acctcgggtc aaactgatga caacgggcaa taacacagtg      660

aggtttaacc ccaacttcta ccgcaatggg aaagtctgct tgagtattct aggtacatgg      720

actggacctg cctggagccc agcccagagc atctcctcag tgctcatctc tatccagtcc      780

ctgatgactg agaaccccta tcacaatgag cccggctttg aacaggagag acatccagga      840

gacagcaaaa actataatga atgtatccgg cacgagacca tcagagttgc agtctgtgac      900

atgatggaag gaaagtgtcc ctgtcctgaa cccctacgag gggtgatgga gaagtccttt      960

ctggagtatt acgacttcta cgaggtggcc tgcaaagatc gcctgcacct tcaaggccaa     1020

actatgcagg acccttttgg agagaagcgg ggccactttg actaccagtc cctcttgatg     1080

cgcctgggac tgatacgtca gaaagtgctg gagaggctcc ataatgagaa tgcagaaatg     1140

gactctgata gcagttcatc tgggacagag acagaccttc atgggagcct gagggtttag     1200

accctgctcc catctcccct tcccccactc aagagtccca gcagaatccc ttccccccac     1260

cccagggatg gagaggcact gtgtatctcc ctccagactc gaagtcatcc tgcaagatgg     1320

caagaaccaa gcaagctccg atcccagggt gtgggagtgg gggcctgttc ccggtctgac     1380

ctccttggca ctggagcatc tggggcttcg ttcatccatt catcccgtat caggggccaa     1440

ggtaccttta caggagcacc tagagcgagg gcctttggca aaaacaaaac aaccaacaca     1500

cctctccaca gggccagctc cttagggata agtggaagat ggaaattgca attccaagag     1560

ggagtgtgcc caaatgattt atggggatac ctggaaggga gcttggggtg ggggctgtct     1620

gtgacactta agcagtctgg gtggttgtct atttgtctgt cttcagtctt gaagcagggc     1680

ttcccaatgc ccttttcctc cctgccttcc ttcccccatt atttcccaca ggccagcata     1740

attttgtttt tcctaattta tagtcactgt tctagacaga ccaaagagaa ggaacagtgg     1800

tggagtctag gctgctgatc agtaagcttt acctagcacc tgagcacctt tctcccctcc     1860

cctctttcct cacccttttc tagatgtaag acagaaagta aatgtgactg ggacttaacc     1920

aaggtcttgg taaagcctgc atggcaccgt aagaagctga aaatactgtt tgttcccgca     1980

atcactgatt tgaaaagttc ccaacacagg cagctgctgt gtatatggga ttagagccac     2040

tacatagaat agtctcttac agattttcat aaatactagt cacaataagg gtatttttct     2100

tgggggtgga gtaaggggga gactgatgct agtccttgtt gtattttgtt gggctgtcct     2160

tgtgtatttt caccccagcc tgtagtcctc ctcacttcaa ccccagggat ttttggggag     2220

caagggtagc caatggcaga gggggttggg gctgggactc tggaggctcc tccccttctt     2280

tctcttcctt ccgcctcccc cgtgccccca gctgctcttg tcactgtctc tgatgggtat     2340

ttgcctggct ttgttgcttc tctatctgta tttagctgca gtgatccttt agctggttgg     2400

ctcagaaaaa aaaaaatgtg ctttaggtgc cctgtaatcc tgggcatcaa gggaatccat     2460

ccttcccctt tttgatatgt tctccccgta cttccagatt tattgttatg gctcccagtg     2520

ggtattggcg attcttgtga tgcagggcct cagtcagtgt ccagccatgc ataagggaga     2580

ggatagtgtg tacctgccct gccctctgct atgaaggtct ctgccttgtg gatcatggga     2640

ctccccttgg aggatctgtg caaagggggg ctgggcacaa aggagaatgt cctatttggg     2700

agggcaggaa gcaaaggaac tggacaggga ttggtgggct tggggaacgg aagtttatct     2760

tggataccct tgaagaggct gggtctcttc acatgaagat cgaaaaggga ccctgcttcc     2820

aatttccctc ttccattcct cgagctactc cagggcttag aagaatgctc ttggtctgtg     2880

ggtccagtgt tgtctgtcat ccatttaagt gttcccactt tcaagtgaca atcctctcct     2940

tggccctgcc atagggcaga gcatgtctgg catagcagcc tgacttttat gccctaatct     3000

tgagttgagg aaatatatgc acaggagtca aagagatgtc tttatatctg actgtatata     3060

aatgaagttt ttttgttttt tttgttttcc tttttggtgc aataaagttt gttttggcag     3120

aa                                                                    3122


<210> 1512
<211> 3120
<212> DNA
<213> Homo sapiens

<400> 1512
ccaagccgga gcccgagctg gaggaagccc ccaggtgcca ggatctgccc ggatccgcgc       60

ccgctccggc cggcaccatg gacagcgagg cattccagag cgcgcgggac tttctggaca      120

tgaacttcca gtcgctggcc atgaaacaca tggatctgaa gcagatggag ctggacacgg      180

cggcggccaa ggtggatgaa ctgaccaagc agctggagtc gctgtggtca gactctcccg      240

cgcctcctgg cccgcaggcc ggaccccctt ctaggccgcc ccggtacagc tccagctcga      300

tccctgagcc cttcggcagc cgagggtccc cccggaaggc ggccaccgac ggcgcagaca      360

ccccgttcgg acgatcagag agtgccccaa ccctacaccc ctacagcccg ctgtccccca      420

agggacggcc gtcgtcgccg cgcaccccgc tctacctgca gccggacgcc tacggcagcc      480

tggaccgcgc gacctcgccc cggccccgcg ccttcgatgg cgcaggcagc tccctcggcc      540

gtgcgccctc cccgcggccc gggccaggcc cgctccgcca gcagggtccc cccacgcctt      600

tcgacttcct gggccgcgca ggctcccccc gcggcagccc cctggcggag gggccccagg      660

ccttcttccc cgagcgtggg ccgtcaccgc gcccccctgc cacagcctac gacgcgccag      720

cgtccgcctt cgggagctcc ctgctaggct ccggcggcag cgcattcgcc ccgcctctgc      780

gcgcgcaaga cgacctgacg ctgcgccggc ggcctccgaa agcctggaac gagtctgacc      840

tggacgtggc gtacgagaag aagccttcgc agacagcgag ctatgaacgc ctggacgtct      900

tcgcaaggcc tgcctcgccg agcctgcagc tgttgccttg gagggagagc agcctggatg      960

gactgggggg caccggcaag gacaacctca ctagcgccac cctgccgcgc aattacaagg     1020

tctctcctct ggccagcgac cggcgttcag acgcgggcag ctaccggcgc tcgctgggct     1080

ccgcggggcc gtcgggcact ttgcctcgca gctggcagcc cgtcagccgc atccccatgc     1140

ccccctccag cccccagccc cgcggggccc cgcgccagcg tcccatcccc ctcagcatga     1200

tcttcaagct gcagaacgcc ttctgggagc acggggccag ccgcgccatg ctccctgggt     1260

cccccctctt cacccgagca cccccgccta agctgcagcc ccaaccacaa ccacagcccc     1320

agccacaatc acaaccacag ccccagctgc ccccacagcc ccagacccaa ccccaaaccc     1380

ctaccccagc cccccagcat ccccaacaga catggccccc tgtgaacgaa ggacccccca     1440

aaccccccac cgagctggag cctgagccgg agatagaggg gctgctgaca ccagtgctgg     1500

aggctggcga tgtggatgaa ggccctgtag caaggcctct cagccccacg aggctgcagc     1560

cagcactgcc accggaggca cagtcggtgc ccgagctgga ggaggtggca cgggtgttgg     1620

cggaaattcc ccggcccctc aaacgcaggg gctccatgga gcaggcccct gctgtggccc     1680

tgccccctac ccacaagaaa cagtaccagc agatcatcag ccgcctcttc catcgtcatg     1740

gggggccagg gcccgggggg ccggagccag agctgtcccc catcactgag ggatctgagg     1800

ccagggcagg gccccctgct cctgccccac cagctcccat tccacccccg gccccgtccc     1860

agagcagccc accagagcag ccgcagagca tggagatgcg ctctgtgctg cggaaggcgg     1920

gctccccgcg caaggcccgc cgcgcgcgcc tcaaccctct ggtgctcctc ctggacgcgg     1980

cgctgaccgg ggagctggag gtggtgcagc aggcggtgaa ggagatgaac gacccgagcc     2040

agcccaacga ggagggcatc actgccttgc acaacgccat ctgcggcgcc aactactcta     2100

tcgtggattt cctcatcacc gcgggtgcca atgtcaactc ccccgacagc cacggctgga     2160

cacccttgca ctgcgcggcg tcgtgcaacg acacagtcat ctgcatggcg ctggtgcagc     2220

acggcgctgc aatcttcgcc accacgctca gcgacggcgc caccgccttc gagaagtgcg     2280

acccttaccg cgagggttat gctgactgcg ccacctacct ggcagacgtc gagcagagta     2340

tggggctgat gaacagcggg gcagtgtacg ctctctggga ctacagcgcc gagttcgggg     2400

acgagctgtc cttccgcgag ggcgagtcgg tcaccgtgct gcggagggac gggccggagg     2460

agaccgactg gtggtgggcc gcgctgcacg gccaggaggg ctacgtgccg cggaactact     2520

tcgggctgtt ccccagggtg aagcctcaaa ggagtaaagt ctagcaggat agaaggaggt     2580

ttctgaggct gacagaaaca agcattcctg ccttccctcc agacctctcc ctctgttttt     2640

tgctgccttt atctgcaccc ctcaccctgc tggtggtggt ccttgccacc ggttctctgt     2700

tctcctggaa gtccagggaa gaaggagggc cccagcctta aatttagtaa tctgccttag     2760

ccttgggagg tctgggaagg gctggaaatc actggggaca ggaaaccact tccttttgcc     2820

aaatcagatc ccgtccaaag tgcctcccat gcctaccacc atcatcacat cccccagcaa     2880

gccagccacc tgcccagccg ggcctgggat gggccaccac accactggat attcctggga     2940

gtcactgctg acaccatctc tcccagcagt cttggggtct gggtgggaaa cattggtctc     3000

taccaggatc cctgccccac ctctccccaa ttaagtgcct tcacacagca ctggtttaat     3060

gtttataaac aaaatagaga aactttcctt ataaataaaa gtagtttgca cagaaattga     3120


<210> 1513
<211> 2072
<212> DNA
<213> Homo sapiens

<400> 1513
ggtagacgcg atctgttggc tactactggc ttctcctggc tgttaaaagc agatggtggt       60

tgaggttgat tccatgccgg ctgcctcttc tgtgaagaag ccatttggtc tcaggagcaa      120

gatgggcaag tggtgctgcc gttgcttccc ctgctgcagg gagagcggca agagcaacgt      180

gggcacttct ggagaccacg acgactctgc tatgaagaca ctcaggagca agatgggcaa      240

gtggtgccgc cactgcttcc cctgctgcag ggggagtggc aagagcaacg tgggcgcttc      300

tggagaccac gacgactctg ctatgaagac actcaggaac aagatgggca agtggtgctg      360

ccactgcttc ccctgctgca gggggagcag caagagcaag gtgggcgctt ggggagacta      420

cgatgacagt gccttcatgg agcccaggta ccacgtccgt ggagaagatc tggacaagct      480

ccacagagct gcctggtggg gtaaagtccc cagaaaggat ctcatcgtca tgctcaggga      540

cactgacgtg aacaagcagg acaagcaaaa gaggactgct ctacatctgg cctctgccaa      600

tgggaattca gaagtagtaa aactcctgct ggacagacga tgtcaactta atgtccttga      660

caacaaaaag aggacagctc tgataaaggc cgtacaatgc caggaagatg aatgtgcgtt      720

aatgttgctg gaacatggca ctgatccaaa tattccagat gagtatggaa ataccactct      780

gcactacgct atctataatg aagataaatt aatggccaaa gcactgctct tatatggtgc      840

tgatatcgaa tcaaaaaaca agcatggcct cacaccactg ttacttggtg tacatgagca      900

aaaacagcaa gtcgtgaaat ttttaattaa gaaaaaagcg aatttaaatg cactggatag      960

atatggaaga actgctctca tacttgctgt atgttgtgga tcagcaagta tagtcagcct     1020

tctacttgag caaaatattg atgtatcttc tcaagatcta tctggacaga cggccagaga     1080

gtatgctgtt tctagtcatc atcatgtaat ttgccagtta ctttctgact acaaagaaaa     1140

acagatgcta aaaatctctt ctgaaaacag caatccaggt tgaagaagaa atgaagaagc     1200

atgaaagtaa taatgtggga ttactagaaa acctgactaa tggtgtcact gctggcaatg     1260

gtgataatgg attaattcct caaaggaaga gcagaacacc tgaaaatcag caatttcctg     1320

acaacgaaag tgaagagtat cacagaattt gtgaattact ttctgactac aaagaaaagc     1380

agatgccaaa atactcttct gaaaacagca acccagaaca agacttaaag ctgacatcag     1440

aggaagagtc acaaaggctt aaaggcagtg aaaatggcca gccagagaaa agatctcaag     1500

aaccagaaat aaataaggat ggtgatagag agctagaaaa ttttatggct atcgaagaaa     1560

tgaagaagca cagaagtact catgtcggat tcccagaaaa cctgactaat ggtgccactg     1620

ctggcaatgg tgatgatgga ttaattcctc caaggaagag cagaacacct gaaagccagc     1680

aatttcctga cactgagaat gaagagtatc acagtgacga acaaaatgat actcagaagc     1740

aattttgtga agaacagaac actggaatat tacacgatga gattctgatt catgaagaaa     1800

agcagataga agtggttgaa aaaatgaatt ctgagctttc tcttagttgt aagaaagaaa     1860

aagacatctt gcatgaaaat agtacgttgc gggaagaaat tgccatgcta agactggagc     1920

tagacacaat gaaacatcag agccagctaa gagaaaagaa atatttggag gatattgaaa     1980

gtgtgaaaaa aaggaatgat aatcttttaa aggctctaca attgaatgag ctcaccatgg     2040

atgatgatac cgctgtgctc gtcattgaca ac                                   2072


<210> 1514
<211> 1698
<212> DNA
<213> Homo sapiens

<400> 1514
atgcctgcat ccttcccgat gctgcgctgt gcgcgttcac cttgctggac agtgtgctgg       60

tcaccctggt gcagggccct gcccgatgga agatgcagct gtttgagcag ccctccctcc      120

ccactcggcc ccacccgaga ccctgtggcc acttttctgg aaacttgtcg ggagcctggc      180

agccagccag caggacccgc ctccctgcgg gccgagtacc tgcccccatc tgtggcttcc      240

atcaaggtgt cggcggagct gctcagagct gccttgaagg acggccactc aggcgtgccc      300

ctgtgctgtg ccaccctgca gtggctcctt gctgagaatg ctgctgtgga cgtcgtgagg      360

gcccgagcac tatcttccat ccagggagtg gcccctgatg gcgccaacgt tcacctcatc      420

gtccgagagg tggccatgac tgacctgtgc ccagcagggc ccatccaggc cgtggagatt      480

caagtggaaa gctcctctct ggccgacatt tgcagggcgc accatgccgt tgtcgggcgc      540

atgcagacga tggtgacaga gcaggccacc cagggctcca gcgctcctga tctccgtgtg      600

cagtacctcc gccagatcca cgccaaccac gagacactgc tgcgggaggt gcagaccctg      660

cgcgaccggc tctgcacgga ggatgaggcc agctcctgtg ccaccgccca gaggctgcta      720

caggtgtacc ggcagctgcg ccaccccagc ctcatcctgc tgtgaccagg cgggcctgcc      780

cctgggctct ggccacgctt ccagcctctg tcacagcccc cccaggcctc atgggttaga      840

gggaaaccga gctggcctgg ccagagccgt cagggaaggt aggacctggc cacgtaggag      900

cagaacgctc atgaaagtgc ttggaggccg tggagcacaa agcagattct gattgggagc      960

aaccgaggcg ggctctgaac ctggccggtc cagcttcgcg tcctctgctg gtgtctctcc     1020

ttctctgacc gcggccgcag cccctgcact cgccttcctc actgctgggc agccttccca     1080

ccaccgcagc agcccctgag gccaggaggc agtgcagggc attctggacc cggagggcca     1140

gagaaacagg atttctgggg tttggacttg gggtgagttt gtaactgttg ctgccacacc     1200

accaggagca ccggctgccc ctctgggtgg cactaccagg tgccccacgg tacccttgtc     1260

acactgttca cacctgcccg gctgcccact ctgggacccc gaggtaggag ggtgctccct     1320

gagaccaaag cacaaaacag catgcaggga gctcctgcaa gtgcccgtgg tctcgtgcca     1380

caccaaggaa gggccagcgg gtggcctgtg gccggaatgc tcaacaacta ggtgcctcca     1440

gccggggcag tacccagcac tgtgcactat tttcagggcc actcagggtg gcgctgtggc     1500

ccgggggggg gccctgagcc ccagccccca gcctcctccc tcagcctggg ctacggccca     1560

cctcctggtg ctggtgtttt catctgggga gggtgctcgc gccgctcccg ctgcaggcac     1620

tgtccgcgat gagtgcgggt aggagccgtg aggtgcttct ctgctgtgac aaacgaccct     1680

gtctgtccgt gaaccttc                                                   1698


<210> 1515
<211> 3141
<212> DNA
<213> Homo sapiens

<400> 1515
tggcggagcc cgggaggcgg agaaggctgt cgttgccttg gccgtcgcat ccccgaggga       60

gtcgtgtcgg cgccaccccg gcccccgagc ccgcagattg cccaccgaag ctcgtgtgtg      120

cacccccgat cccgccagcc actcgcccct ggcctcgcgg gccgtgtctc cggcatcatg      180

tgtggtatat ttgcttactt aaactaccat gttcctcgaa cgagacgaga aatcctggag      240

accctaatca aaggccttca gagactggag tacagaggat atgattctgc tggtgtggga      300

tttgatggag gcaatgataa agattgggaa gccaatgcct gcaaaatcca gcttattaag      360

aagaaaggaa aagttaaggc actggatgaa gaagttcaca agcaacaaga tatggatttg      420

gatatagaat ttgatgtaca ccttggaata gctcataccc gttgggcaac acatggagaa      480

cccagtcctg tcaatagcca cccccagcgc tctgataaaa ataatgaatt tatcgttatt      540

cacaatggaa tcatcaccaa ctacaaagac ttgaaaaagt ttttggaaag caaaggctat      600

gacttcgaat ctgaaacaga cacagagaca attgccaagc tcgttaagta tatgtatgac      660

aatcgggaaa gtcaagatac cagctttact accttggtgg agagagttat ccaacaattg      720

gaaggtgctt ttgcacttgt gtttaaaagt gttcattttc ccgggcaagc agttggcaca      780

aggcgaggta gccctctgtt gattggtgta cggagtgaac ataaactttc tactgatcac      840

attcctatac tctacagaac aggcaaagac aagaaaggaa gctgcaatct ctctcgtgtg      900

gacagcacaa cctgcctttt cccggtggaa gaaaaagcag tggagtatta ctttgcttct      960

gatgcaagtg ctgtcataga acacaccaat cgcgtcatct ttctggaaga tgatgatgtt     1020

gcagcagtag tggatggacg tctttctatc catcgaatta aacgaactgc aggagatcac     1080

cccggacgag ctgtgcaaac actccagatg gaactccagc agatcatgaa gggcaacttc     1140

agttcattta tgcagaagga aatatttgag cagccagagt ctgtcgtgaa cacaatgaga     1200

ggaagagtca actttgatga ctatactgtg aatttgggtg gtttgaagga tcacataaag     1260

gagatccaga gatgccggcg tttgattctt attgcttgtg gaacaagtta ccatgctggt     1320

gtagcaacac gtcaagttct tgaggagctg actgagttgc ctgtgatggt ggaactagca     1380

agtgacttcc tggacagaaa cacaccagtc tttcgagatg atgtttgctt tttccttagt     1440

caatcaggtg agacagcaga tactttgatg ggtcttcgtt actgtaagga gagaggagct     1500

ttaactgtgg ggatcacaaa cacagttggc agttccatat cacgggagac agattgtgga     1560

gttcatatta atgctggtcc tgagattggt gtggccagta caaaggctta taccagccag     1620

tttgtatccc ttgtgatgtt tgcccttatg atgtgtgatg atcggatctc catgcaagaa     1680

agacgcaaag agatcatgct tggattgaaa cggctgcctg atttgattaa ggaagtactg     1740

agcatggatg acgaaattca gaaactagca acagaacttt atcatcagaa gtcagttctg     1800

ataatgggac gaggctatca ttatgctact tgtcttgaag gggcactgaa aatcaaagaa     1860

attacttata tgcactctga aggcatcctt gctggtgaat tgaaacatgg ccctctggct     1920

ttggtggata aattgatgcc tgtgatcatg atcatcatga gagatcacac ttatgccaag     1980

tgtcagaatg ctcttcagca agtggttgct cggcaggggc ggcctgtggt aatttgtgat     2040

aaggaggata ctgagaccat taagaacaca aaaagaacga tcaaggtgcc ccactcagtg     2100

gactgcttgc agggcattct cagcgtgatc cctttacagt tgctggcttt ccaccttgct     2160

gtgctgagag gctatgatgt tgatttccca cggaatcttg ccaaatctgt gactgtagag     2220

tgaggaatat ctatacaaaa tgtacgaaac tgtatgatta agcaacacaa gacacctttt     2280

gtatttaaaa ccttgattta aaatatcacc ccttgaagcc tttttttagt aaatccttat     2340

ttatatatca gttataatta ttccactcaa tatgtgattt ttgtgaagtt acctcttaca     2400

ttttcccagt aatttgtgga ggactttgaa taatggaatc tatattggaa tctgtatcag     2460

aaagattcta gctattattt tctttaaaga atgctgggtg ttgcatttct ggaccctcca     2520

cttcaatctg agaagacaat atgtttctaa aaattggtac ttgtttcacc atacttcatt     2580

cagaccagtg aaagagtagt gcatttaatt ggagtatcta aagccagtgg cagtgtatgc     2640

tcatacttgg acagttaggg aagggtttgc caagttttaa gagaagatgt gatttatttt     2700

gaaatttgtt tctgttttgt ttttaaatca aactgtaaaa cttaaaactg aaaaatttta     2760

ttggtaggat ttatatctaa gtttggttag ccttagtttc tcagacttgt tgtctattat     2820

ctgtaggtgg aagaaattta ggaagcgaaa tattacagta gtgcattggt gggtctcaat     2880

ccttaacata tttgcacaat tttatagcac aaactttaaa ttcaagctgc tttggacaac     2940

tgacaatatg attttaaatt tgaagatggg atgtgtacat gttgggtatc ctactacttt     3000

gtgttttcat ctcctaaaag tggtttttat ttccttgtat ctgtagtctt ttatttttta     3060

aatgactgct gaatgacata ttttatcttg ttctttaaaa tcacaacaca gagctgctat     3120

taaattaata ttgatatatt c                                               3141


<210> 1516
<211> 2701
<212> DNA
<213> Homo sapiens

<400> 1516
gctttggcgg cggttggtgg ccgtgcgggc ggggagggag ggggaggaga gaagaggagg       60

tggagaaggc ttgggctcgc gccgctgaag tcggcttacc cgctggccgc ctcctgacaa      120

gcgggaggga tccgcggtgg acccagggaa gcggaggagc ctggcggcca ccccctcttc      180

ctcacttccc tgtactctca tcgctctcgg cctccgacac gaaaaggaag caaatgagct      240

gatggaagat ctgtttgaaa ctttccaaga tgagatggga ttctccaaca tggaagatga      300

tggcccagaa gaggaggagc gtgtggctga gcctcaagct aactttaaca cccctcaagc      360

tctacggttt gaggaactac tggccaacct actaaatgaa caacatcaga tagcgaagga      420

actatttgaa cagctgaaga tgaagaaacc ttcagccaaa cagcagaagg aggtagagaa      480

ggttaaaccc cagtgtaagg aagttcatca gaccctgatt ctggacccag cacaaaggaa      540

gagactccag cagcagatgc agcagcatgt tcagctcttg acacaaatcc accttcttgc      600

cacctgcaac cccaatctca atccggaggc cagtagcacc aggatatgtc ttagctggga      660

acctttgctc aaagctccat cgcccttcac catcagtaca accccaagtt tcagaccctg      720

ttccaaccct gtaacttgat gggagctatg cagctgattg aagacttcag cacacatgtc      780

agcattgact gcagccctca taaaactgtc aagaagactg ccaatgaatt tccctgtttg      840

ccaaagcaag tggcttggat cctggccaca agcaaggttt tcatgtatcc agagttactt      900

ccagtgtgtt ccctgaaggc aaagaatccc caggataaga tcctcttcac caaggctgag      960

gacaatttgt tagctttagg actgaagcat tttgaaggga ctgagtttct taaccctcta     1020

atcagcaagt accttctaac ctgcaagact gcccgccaac tgacagtgag aatcaagaac     1080

ctcaacatga acagagctcc tgacaacatc attaaatttt ataagaagac caaacagctg     1140

ccagtcctag gaaaatgctg tgaagagatc cagccacatc agtggaagcc acctatagag     1200

agagaagaac accggctccc attctggtta aaggccagtc tgccatccat ccaggaagaa     1260

ctgcggcaca tggctgatgg tgctagagag gtaggaaata tgactggaac cactgagatc     1320

aactcagatc aaggcctaga aaaagacaac tcagagttgg ggagtgaaac tcggtaccca     1380

ctgctattgc ctaagggtgt agtcctgaaa ctgaagccag ttgccgaccg tttccccaag     1440

aaggcttgga gacagaagcg ttcatcagtc ctgaaacccc tccttatcca acccagcccc     1500

tctctccagc ccagcttcaa ccctgggaaa acaccagccc aatcaactca ttcagaagcc     1560

cctccgagca aaatggtgct ccggattcct cacccaatac agccagccac tgttttacag     1620

acagttccag gtgtccctcc actgggggtc agtggaggtg agagttttga gtctcctgca     1680

gcactgcctg ctatgccccc tgaggccagg acaagcttcc ctctgtctga gtcccagact     1740

ttgctctctt ctgcccctgt gcccaaggta atgatgccct cccctgcctc ttccatgttt     1800

cgaaagccat atgtgagacg gagaccctca aaaagaaggg gagccagggc ctttcgctgt     1860

atcaaacctg cccctgttat ccaccctgca tctgttatct tcactgttcc tgctaccact     1920

gtgaagattg tgagccttgg cggtggctgt aacatgatcc agcctgtcaa tgcggctgtg     1980

gcccagagtc cccagactat tcccatcgcc accctcttgg ttaaccctac ttccttcccc     2040

tgtccattga accagcccct tgtggcctcc tctgtctcac ccttaattgt ttctggcaat     2100

tctgtgaatc ttcctatacc atccacccct gaagataagg cccacatgaa tgtggacatt     2160

gcttgtgctg tggctgatgg ggaaaatgcc tttcagggcc tagaacccaa attagagccc     2220

caggaactat ctcctctctc tgctactgtt ttccccaaag tggaacatag cccagggcct     2280

ccaccagtcg ataaacagtg ccaagaagga ttgtcagaga acagtgccta tcgctggacc     2340

gttgtgaaaa cagaggaggg aaggcaagct ctggagccgc tccctcaggg catccaggag     2400

tctctaaaca actcttcccc tggggattta gaggaagttg tcaagatgga acctgaagat     2460

gctacagagg aaatcagtgg atttctttga gctaggagaa taagagtctg gagactggga     2520

gccttcactt cggcctccga ttggtggcgc atagggtgta accaatagga aacccctaaa     2580

gggtacttaa accccagatt ttgcaactgg ggctcttgag cagcttgctt tagcctgctc     2640

ccactctgtg gaatatactt ttgcttcaat aaatctgtgc ttttattgct tcattgtttc     2700

a                                                                     2701


<210> 1517
<211> 1636
<212> DNA
<213> Homo sapiens

<400> 1517
gctggatggg gcccggcctc ttcccagcgt tcctcctccg gccccaggtc accgccagca       60

cgcgcctgct tcccgtctgc gcgagtccac gcagctcccc aggcccttca ccagcacagc      120

agcagcaggc atggcagcaa gcgtggagca gcgcgagggc accatccagg tgcagggcca      180

ggccctcttc ttccgagagg ccctgcccgg cagtgggcag gctcgcttct ctgtactgct      240

gctgcatggt attcgcttct cctccgagac ctggcagaac ctgggtacac tgcacaggct      300

ggcccaggct ggctaccggg ctgtggccat tgacctgcca ggtctggggc actccaagga      360

agcagcagcc cctgccccta ttggggagct ggcccctggc agcttcctgg cggctgtggt      420

ggatgccttg gagctgggcc ccccggttgt gatcagtcca tcactgagtg gcatgtactc      480

cctgcccttc ctcacggccc ctggctccca gctcccgggc tttgtgccag tggcccccat      540

ctgcactgac aaaatcaatg ctgccaacta tgccagtgtg aagactccag ctctgattgt      600

atatggagac caggacccca tgggtcagac cagctttgag cacctgaagc agctgcccaa      660

ccaccgggtg ctgatcatga agggggcggg gcacccctgt tacctggaca aaccagagga      720

gtggcataca gggctgctgg acttcctgca ggggctccag tgaagcccag cactgctgca      780

gggggtgggc tgcctgcctg ctctgagctc tctcttgcac gctctctctt ctctcccagg      840

ctctggctca tgcacatgca acaggtgcgt ctgtctatat gtctgggttc ttgtcttttg      900

tggtctgttt gtcttttcta cctctttctc ttgcagtgat agactgaggg ggtaaaatca      960

agagaaaaaa ctctcaggaa tcaaggaaca taatcctgtg gagggtaatc cattacatga     1020

gcttctcctg ttcttccact ttcctgcctg gctttcactc cttcccctgc tctgcccagc     1080

ctttccctcc cacccactcc tccttctgca aatgccctga aggccagccc ttaccccaac     1140

acccacttcc ccacctcctt aggccccaga tacatacatg cccacatgca cgcttacatg     1200

tttagagcca tccttgtttc caaatatgac ccttcgcttg agggcaactg cataggtaca     1260

tctaactctg gactggcatg cacattgtca tgtgcagctt tgcatataca cacatgcata     1320

catgagcctc cacacaagca cttgcacaca tgtggactcc taaccatgct aacctcactg     1380

gctgggaagg tggggacccc atgggccagc ccttgcagga ggcccttttg caaggcttag     1440

ggtgtggcca gccctgaaag ctacttggac acaggtttca gctggcccca gcccagaagt     1500

gacccccaga aagggagggc caccgctttg ccccctgctt ttacccttcc ttctgggtgc     1560

tctacacctc aggttaccag gcctgaggca tctcagccaa gcttgtttcc tgctctgagg     1620

cttgtggggt gggagc                                                     1636


<210> 1518
<211> 3838
<212> DNA
<213> Homo sapiens

<400> 1518
agccgttccc acgtgagagg ctccgcggcc gaattcctcg cgtgcagcag gcgcggaccg       60

cccggcgtcc ggccggactg agagccctgg tccggcgcgc gccgccggcc gggcgggagg      120

cgggggcggg ctcggctgcg ccccgatgcg gcggcgacct ccgggtctgt gagcccggcg      180

cgcgccgtcg gagcccctcg cgcagccgct ggtagcgtcc ccccgggcac ccggcatgcg      240

ggcggccgac tcgggctcgt gggagcgcgt ccgccagctc gcggcgcagg gcgagccggc      300

gccttcctgc ggggcggggg ccgggcccgc gcggcccccg ggacccgcag cctgcgagca      360

gtgcgtggac gcggcggggc ccggcgatcg gccccgcgcc ggggttcccc gggtccgagc      420

ggatggcgac tgcagccagc ccgtgctcct gcgggaagaa gtgtcgcggc tccaggagga      480

agttcacctt ctccggcaga tgaaggagat gttggcgaag gacctggagg agtcgcaggg      540

cggcaagtcc tctgaggtcc tctcggccac cgagctcagg gtccagctgg cccagaagga      600

gcaggagcta gccagagcca aagaagcctt gcaggccatg aaagctgatc ggaagcgctt      660

aaagggcgag aagacagacc tggtgagcca gatgcagcag ctgtatgcca cactggagag      720

ccgcgaggag cagctccgag acttcatccg caactatgag cagcaccgca aggagagcga      780

ggatgcggtc aaagcgctgg ccaaggagaa ggacctgctg gagcgtgaga agtgggagct      840

gcggcgccaa gccaaggagg ccacagacca cgccacggca ctgcgctccc agctggacct      900

caaggacaac cggatgaagg agctggaggc cgagctggcc atggccaaac agtccttagc      960

tacgctgacc aaggacgtcc ccaagcggca ttccctcgcc atgccgggcg agacggtgct     1020

caatggcaac caggagtggg tggtgcaggc ggacctcccg ctgaccgcag ccatccggca     1080

gagtcaacag actctctacc actcacaccc ccctcaccct gcggaccggc aagcggtcag     1140

ggtgagcccc tgccactccc ggcagccctc tgtcatctcc gacgcatctg ccgccgaagg     1200

cgaccggtcg tccacaccga gcgacatcaa ctcccctcga caccggacac actccctctg     1260

caacggcgac agtcccggcc cagttcagaa gaacctgcac aaccctattg tacagtcact     1320

agaggatctt gaagaccaaa aacggaaaaa gaagaaagag aagatgggat tcggctccat     1380

ctcccgcgtc ttcgccagag ggaagcagcg gaagtccctc gaccccggcc tctttgatgg     1440

taccgcccct gattattaca tagaggagga cgcggactgg tgatacgcgc tcccctgcgc     1500

ctgctgcccg caggcgtgtc tgtgcgtgtg ggcgtgtgtg caagcgagcg tgggtgcgcg     1560

tgtggccgtg cgtggggtgc gtgtgcacgt gtgcgctggc acacatgggt gctgggtgtg     1620

gccgagcgcc tctaacaagt gaaaacacga gtgtgaacct ctctcccctg cgtcgccacc     1680

tctgtaattg atgtacatac cgcaaaccgt gtgtgaacct gtcaactctc tgtcgtcttt     1740

ggagcgatac agttgtgttg ttaatctggt ttattatttt tcttcagtgt ttggtttttc     1800

tttttctttt tgtttggttc gtcggtttgt ttttgttttt gtttttttcc ccctttctcc     1860

tcccctcctc ctttttatga aacttgaaaa cttgaaggac tgctgtgtat ttgtaaataa     1920

caaaactatt gtgcactctg tgcttgtaaa tgtccctcgt ccaaaccgct actcctggag     1980

cccgtctggc agaggatgtg gtctgttttt gatgtccccc ctcccgcccc cctggtgtga     2040

acgtgtggga ccagaccctg tcctgggggt gcgcccaagt cactttaacc acaaaacgcc     2100

atcgtcgtca gggtaagctc tgctctctac aaagactcgc gagccgggcc aaggggcctt     2160

gtcttggctg ggtttgtcag aggtcaaacc ggctctttta aacggcctac cagtttttaa     2220

attgcattgc cgtttctttc tttatgaaaa aaaagaaaaa aagaaaattg tttcatttaa     2280

tttatttgca caaatgctga aaacttattc tatctaaatt attacataaa tattggaatg     2340

tctatttttc catggggtgg gcgggaggtg ggtgtctctg ttgacttgtc tgttctgtta     2400

ccatgctgct acccaactgt gcaaagtagt ttagggtggc cagaacccag ggaccattgg     2460

atttcaaagc ttgctttttc tgttggttct tctctctcct tctctctctg tctctcccat     2520

tctcctgccc atgcatgaaa ggatcctcca ccttcttccc acccagagct ccctccaggc     2580

ctttctctat atatttattt atctgacata cagaacacga ctttagtgag cagagtgctg     2640

acagtcatgg tccccttctt tgggtctgtc ttttgagaga ggttgagttc agggcaagac     2700

agcctgccac acatccaagg gtacgaccag tgggaccctg gcctgagtct gttctccgag     2760

gggcctccag cagcttctgt tcctccctgc agctgtgtct ttcttgtcct gggtttagga     2820

tgcaggtggg ccaggcaggt gttgttaggg gaggcaccca cttcaaaagg agggccacag     2880

tggggacaca gagtccagca cctgagccct ccaccctccc cattctggtt ggttccatca     2940

gccacactta gaatctccca ggatcccttg gactccgtcc cccaacttgt cacagcagcc     3000

tgagcctacc caccccagga gacaagagct ggcaggaaca tctgcctata tggggggtgg     3060

cgttggcccc aaagaggctt caccagcaaa ggaactgtgt gtattttaat gccaggggac     3120

ggaggatgtg tgagctgttc agcaaggtct gcccaaggcc taaaactcaa tttccttatt     3180

cttttgcttc tgctcgtcct taacaactaa cagctcaacc cacacctcta gacaacagta     3240

gtcgtgcttt ctgctaacgg tgacattttc agctcttaaa aagaagcaag gagattttca     3300

aatgctagag tatctctatc agaaggcata ggacattgtg tccaaagtct caagaacaaa     3360

caacactttc cttctgacct ggtccaaaag tcagcaaaca gcaagcaggc agaggccctc     3420

ataaggactt ttctgtcctc ctttgaccaa actgtttaac cgagcctagg ggtgacgggg     3480

agcgacccaa gctggcatct ttctctacgg agacagattt tagaaaatac ttttcttgcc     3540

catgaatttc ttttctggtt gatttttatc attttccctt tacttacaag aaaataagat     3600

tgcaaccact cctgctaatg atttagtagt tccttttcat ttcagttttt gtaaattagg     3660

agataattct aagagttact aaaggatgat ttatttaaga gaactacgtc aaatagcgaa     3720

tgagttatgg gtaacattag acgaaaataa cctttcccgt gggaaaggtt tctcgaaggc     3780

atggatgcaa atataaaata ttaaaaaaaa tctaaataaa gcttatttta aaatatga       3838


<210> 1519
<211> 807
<212> DNA
<213> Homo sapiens

<400> 1519
ggaaggcagc tgaactcggc gcctggaaag atggaggcag cggagacaga ggcggaagct       60

gcagccctag aggtcctggc tgaggtggca ggcatcttgg aacctgtagg cctgcaggag      120

gaggcagaac tgccagccaa gatcctggtt gagtttgtgg tggactctca gaagaaagac      180

aagctgctct gcagccagct tcaggtagcg gatttcctgc agaacatcct ggctcaggag      240

gacactgcta agggtctcga ccccttggct tctgaagaca cgagccgaca gaaggcaatt      300

gcagctaagg aacaatggaa agagctgaag gccacctaca gggagcacgt agaggccatc      360

aaaattggcc tcaccaaggc cctgactcag atggaggaag cccagaggaa acggacacaa      420

ctccgggaag cctttgagca gctccaggcc aagaaacaaa tggccatgga gaaacgcaga      480

gcagtccaga accagtggca gctacaacag gagaagcatc tgcagcatct ggcggaggtt      540

tctgcagagg gtaagctgtt gttccctgag gctgaggctg aggcagagaa tcttccagat      600

gataaacccc agcagccgac tcgaccccag gagcagagta caggagacac catggggaga      660

gaccctggtg tgtccttcaa ggctgttggt ctacaacctg ctggagatgt aaatttgcca      720

tgacttcctg gaggacagca gcatggagaa agatcctaga aaaggcctct gacttccctc      780

acctcccaac catcattaca ggaaaga                                          807


<210> 1520
<211> 7011
<212> DNA
<213> Homo sapiens

<400> 1520
tgttaggaaa gaaaaaaaaa ttcctgatgt ctggtccaag caggaattcc ccggtggatt       60

ggggaatgtc tggcttttcc tcagcttatt gatctctgtg gtaaccactg gaggccccca      120

gaagacccat agaaatgaga ggcctgaggt ctacaagtcg ctgctagaaa tattttagcc      180

tctccaaagc ccagaatgca gccccgaccc aagtttgtaa gggttctggg tgcacgctga      240

ccctgcgcgg gcagacgcgc cctttgctcc aggtccggac ctgggcgctg ctatagcaac      300

gtcctggacg cccagacctt aggccgccgc cgccgcggaa gcgaggaacc cggccttctc      360

ccgctcctga gggctgtggc ggcggcggcc cgggaggcgg cccaggctgg gtaaagaccg      420

cccggctcct cctatgcaag ctgaggcagc ggattggttt tcaagcatgc ccttccagaa      480

gcatgtctac tacccgctcg ccagcggccc agaggggccc gacgtcgctg tggccgccgc      540

cgccgcgggt gcggcctcca tggcctgtgc gccccccagc gcggcttcgg ggcccctgcc      600

cttcttccag ttcaggccgc ggctggagag tgtggactgg cggcggctga gcgccatcga      660

cgtggacaag gtggcggggg ctgtggacgt gctgacgctg caggagaaca tcatgaacat      720

caccttctgc aagctggaag acgagaagtg cccacactgc cagtcggggg tggacccggt      780

gctgctgaag ctcatccgtc tggcgcagtt caccatcgag tacttgctgc actcacaaga      840

gttcctcacc tcgcagctgc acaccctgga ggagcggctg cgcctgagcc actgcgacgg      900

cgagcagagc aagaagctgc tcaccaagca ggcgggggag atcaagacgc tcaaggaaga      960

gtgcaaacgc cggaagaaga tgatctccac ccagcagctg atgatcgagg ccaaagccaa     1020

ctattaccag tgccattttt gtgacaaggc ctttatgaac caagcttttc tacaaagtca     1080

cattcaacgc cgccacactg aagaaaattc tcattttgag tatcagaaaa atgcacagat     1140

tgagaagctc cggagtgaga tcgtcgtatt gaaggaagag ctgcagctca ccaggtctga     1200

gctagaggct gcacaccatg ccagtgcagt cagattctcc aaggaatatg aaatgcagaa     1260

aacaaaagag gaagactttt tgaagttatt tgacaggtgg aaagaagaag aaaaggagaa     1320

actagttgat gaaatggaaa aagtcaagga gatgtttatg aaggaattta aagaattaac     1380

ttcgaagaat tcagcattag aatatcaact gtcagaaatc cagaagtcca atatgcagat     1440

caagtccaac ataggcacat taaaagatgc acacgagttt aaagaagacc gttctccata     1500

tccccaggat ttccataatg tcatgcagct tcttgatagt caggaaagca aatggacagc     1560

tcgagttcaa gctattcatc aagaacacaa gaaagagaag ggtcggctcc tgtcacatat     1620

agagaaactt cgaacctcaa tgatagatga tctaaatgca agcaatgttt tctataagaa     1680

aaggatagaa gagctagggc agagactcca ggagcagaat gagctgatta taactcagag     1740

acagcagatt aaagacttta cctgtaatcc attaaacagt atcagtgaac ccaaagtgaa     1800

tgccccagcc ctgcacactt tggaaactaa atcaagtctg ccaatggtgc atgaacaggc     1860

attctcgtcg cacatactgg aaccaataga agaactttca gaggaagaaa aaggaaggga     1920

aaatgaacag aaattaaata acaacaaaat gcatttaagg aaagctttga agagtaactc     1980

ctccctcact aagggactaa gaacaatggt ggagcagaac ttgatggaga aactggaaac     2040

cttggggatt aatgcagata tacgtggcat ttcaagtgat cagttgcata gagtactaaa     2100

aagtgtggaa tcagaaagac ataagcaaga aagagaaata cctaactttc atcaaattcg     2160

agaattcctt gaacatcaag tcagctgtaa aattgaggag aaagcactac tctcttcaga     2220

tcagtgcagt gtttctcaaa tggataccct ttcaactgga gaagtaccca aaatgataca     2280

acttccttcc aaaaacagac aactgattag acaaaaagct gtttctactg ataggacatc     2340

tgttccaaaa attaagaaaa atgtcatgga agatcctttt cccagaaagt cttcaactat     2400

tacgacccct ccttttagtt cagaggagga gcaggaggac gacgacctca tccgggcata     2460

cgcatcccca ggcccacttc ctgtgccgcc accacaaaac aagggcagct tcgggaagaa     2520

cacagtgaaa agtgacgcgg acgggaccga gggaagcgaa atcgaggaca ctgatgattc     2580

tcccaagccc gcaggagtcg ccgttaaaac acctactgaa aaagttgaaa agatgtttcc     2640

acatcgcaaa aatgtgaaca aaccagtcgg tggaactaat gtccctgaga tgtttatcaa     2700

aaaagaagaa ttacaagaac taaagtgtgc ggatgtggag gatgaagact gggacatatc     2760

atccctagag gaagagatat ctttgggaaa aaaatctggg aaagaacaga aggaacctcc     2820

acctgcgaaa aatgaaccac attttgctca tgtgctaaat gcctggggcg catttaatcc     2880

taaggggcca aagggagaag gacttcaaga aaatgaatca agcacattaa aaagcagctt     2940

agtaactgtg actgattgga gcgacacttc agatgtctaa ttccacatgt cagaagatta     3000

ttccagaagc cagcagtatt tcagtatcac agtgtttcag taatttgcct ccatgattct     3060

agtgcttctg ccttaccgtg tttcccacag caacacagag actgattcaa agaacaatgg     3120

tctctttaat ggcacccaat acagtattga aaatcagatc atcaacagta tttcgaagca     3180

tgtaaaggtg tttaagactt ccgctgctgc ttaaaaataa catgtcattg aagtcataaa     3240

aagttttttc ttcagaaagg tactctagtg ttaagtgtat ttttttcaac taatttttta     3300

gtgaattttt tttaaactta cagcatgttt tggtttgaat tactaaaact ttaaaaaata     3360

tttttcttat gtatgctgtc gtatcgtagg cgtttatatt ataaaattct gttagtagtc     3420

ttaaaattga attggtggaa ccactaatcc ttaaaagtta gtctggttat ttttcatata     3480

gaagtaagtt taatccgagt gtggtggtgt tcacctttaa tcccagctac ttgggaggct     3540

gaggtgggag gataacttga gcacaggagt tcaagaccag cgtgggcaat atagcaagac     3600

tccacccctc cacaccccaa aaaagtaagt ttaggattag aatatagcta ggtccaatgt     3660

taaatacatt ttcctggagt acatttgtca cattcagctt tgagccactg taagcatgtt     3720

actattaaat ggttggttat tttatatagc atattcttta tcttggatat tttatgaata     3780

aagtatagtt attttaagtg ccaattaatt tatcagacta aatagaaaat atttgagcca     3840

ttactgaatt cacatatgta tgtttttttt tactatttaa aatacccaac atgtattatg     3900

aaatacctca aaagtaattt agttacattc ttaaacaatg acattgtcga aagaaagttc     3960

ttataagctg ttttttgcat ttttataact tggttatact atattctgtt tccaagtaac     4020

cttttaacta aaagatttgt tgggttttag atctcttttc atttgtcaac cttttcagta     4080

aagccctctg ttacatcact gtgactgtgg ctgtgttatt agagatgaat tctgagttaa     4140

atttgtactt attaggggtc ttacagaggg agaatctggc cttgattgct atgccatatg     4200

acattctgtc ctaatggtta gaacaaatct ttatctgttt ccacccaccc tgggatcctt     4260

tttacttgta gcccattcct gccctctaaa agaatccttc caacttccta taggggccat     4320

ttcatgcaga tatactcact ttatatgtat gtttctaaaa gctttagtga aggctgaatc     4380

caagtttcat gtagtaggac agagaacaga aggccgaatc caagtttcat gtggtaggac     4440

agagaacggc aatctacaaa actacaccaa gcctaagatg gcccatgtgc cactttgttc     4500

attcatttat ttattcagca gatatttatt gaaccacttg gtctggtttg gttttgaaca     4560

cgcactaatt catttaatta caacaacttt gcgatgtagt tattgttata atcctcatcc     4620

taaaggtgtg agaaacagag ttattaagta agttgccaga agccatacaa gtacaaagtg     4680

tcaaggggag actttaagcc aggtctctat tccatgtttt gtgtctgcca tgttttcatt     4740

cctgagcaga agagcttggg gaaatgaact tttgctaagt aaacccagta tttaaattaa     4800

gtcactatat ctgtgtcttt taagagcccc tcctttagct tacatggtta gttgtatctt     4860

tttttttttt tttttttgag acagagtctc actatgttgc ccaggcttga gcgcagtggc     4920

accatctcgg ctcactacaa cctccgcctc ccagattcaa gcgattttcc tgcctcagcc     4980

tcccaagtag ctgggattac aggtgcccac caccatgcct ggcttaattt tttgtatttt     5040

tagtagagat gaggtttcac catgttggcc agactggtct cgaactcctg acctcaaatg     5100

atccgctgtc ttgtcctccc aaagtgctgg gattataggc gtgagccatc gcgccctgct     5160

gcatttcatt tttttgtata aaatttggtt tgttcgtttt tgaggggaac cattccttta     5220

tgttgcccct tactgatgcc caactaatgt gtttctggtt actaacagac cttcatcccc     5280

caccctccct aaattcttcg gtgtaatcta agcgttatct gcaccacttc tgaataataa     5340

atgtgtttga aatgcacacc tacacaaccc tgtcccacac tggcctgtag gacctaatct     5400

accttcatgt ctttcagttg atttgtattt ctgcaaaaga tatttcaagg attatcaagg     5460

tatggaattt tttttatttt ttatctttta acaaacttgt tcatttcctt ttctttccat     5520

tgagcacctc tgaacaatgt gattcttttt tttaagtctt tcacacttca ggaaaatact     5580

acattcaccc acgttgtgat tcatatcgga cagtttctta ctcaaagata acacaaatac     5640

caattcttat tcatactttg aaactatatt ttaccctaga ctgccttggt tcaaaggcct     5700

agtttcgaca ttactgtggc aaattattta agctctctgt tttcatttct ttttctgtaa     5760

atgcaggatg aaaacaatat gtatctccta ggatggctgt gaggagtgag tgagacagga     5820

catgaaaggt gtgtatgaac tgtgataact gttgcccttg tgggcatgtt atatagggct     5880

ggctctagga agaagcctgt gtcttttttc agaaatccct ggagcaactt aaatgtcttt     5940

agaaatgaca agtctctcag ttatccagtt agccgtaaac aggttctgga agacacacct     6000

agatagaact cggcccgtca gttctgagtg aggcacgtac cacttgggct tgggatgtcc     6060

ttaacccatt tatgcctgag gttgcaattt tttgaatttt tccaatcaca ccttggcgat     6120

gaccttgagc agtaggatat aaataactcc cacatgctta gtgttccaat aatggaacac     6180

taggcataaa caggttttaa ttggctcctc agtcaaccat gaccaatatc tctatctcag     6240

cttctgctga tgccctagct cagggctctg cattccgtgc cagggacgcc tcagcccctt     6300

aacatggatg tgccacatga caggcaataa tatattggcc ccattagccc ttcctggagc     6360

agtcataatg aattacagtc atgacaggca catgtaagaa accaaaattt gctaaatatg     6420

tacatgagtc ttcatcacag catcgtttat gaaaacaact aaatattcac taatggtgcc     6480

agtggaataa atcagagaac atcccctgct acgtaactct ctgcatacat caaagagaat     6540

ggtgtggctt tgctttttca acaatctact gagtggccat gggcatgtgg atatggccat     6600

gaatgagcaa gatcctctct gatcctgtag aagttaagtt ctaccagata acttgctgct     6660

tcaacaaaaa gatttacctt tttaaataaa tgttgtagaa tacttaaaaa aaacaaacta     6720

gaatttgcct gtgtgcagcc agtaacatgt ctatttaacc tggacacctt ttgaggaata     6780

ttctcagatt gcccccatgc tgtttataag acattgttcc ttatacacct gtttatgaat     6840

gaaaagaaac ataaggagtg ggtacaaaga cttctatcta tgaatgatta aaaaggctag     6900

agtacgaata cttcttgaac ctttggtact aaatgctttt catgttctat ataaatgtag     6960

aaaacatttt acaaatcctg taaataaact gtttattttt tatagaaagc c              7011


<210> 1521
<211> 2147
<212> DNA
<213> Homo sapiens

<400> 1521
ggtagacgcg atctgttggc tactactggc ttctcctggc tgttaaaagc agatggtggt       60

tgaggttgat tccatgccgg ctgcctcttc tgtgaagaag ccatttggtc tcaggagcaa      120

gatgggcaag tggtgctgcc gttgcttccc ctgctgcagg gagagcggca agagcaacgt      180

gggcacttct ggagaccacg acgactctgc tatgaagaca ctcaggagca agatgggcaa      240

gtggtgccgc cactgcttcc cctgctgcag ggggagtggc aagagcaacg tgggcgcttc      300

tggagaccac gacgactctg ctatgaagac actcaggaac aagatgggca agtggtgctg      360

ccactgcttc ccctgctgca gggggagcag caagagcaag gtgggcgctt ggggagacta      420

cgatgacagt gccttcatgg agcccaggta ccacgtccgt ggagaagatc tggacaagct      480

ccacagagct gcctggtggg gtaaagtccc cagaaaggat ctcatcgtca tgctcaggga      540

cactgacgtg aacaagcagg acaagcaaaa gaggactgct ctacatctgg cctctgccaa      600

tgggaattca gaagtagtaa aactcctgct ggacagacga tgtcaactta atgtccttga      660

caacaaaaag aggacagctc tgataaaggt atgcagtagc caactatatc agcatgaggc      720

cgtacaatgc caggaagatg aatgtgcgtt aatgttgctg gaacatggca ctgatccaaa      780

tattccagat gagtatggaa ataccactct gcactacgct atctataatg aagataaatt      840

aatggccaaa gcactgctct tatatggtgc tgatatcgaa tcaaaaaaca agcatggcct      900

cacaccactg ttacttggtg tacatgagca aaaacagcaa gtcgtgaaat ttttaattaa      960

gaaaaaagcg aatttaaatg cactggatag atatggaaga actgctctca tacttgctgt     1020

atgttgtgga tcagcaagta tagtcagcct tctacttgag caaaatattg atgtatcttc     1080

tcaagatcta tctggacaga cggccagaga gtatgctgtt tctagtcatc atcatgtaat     1140

ttgccagtta ctttctgact acaaagaaaa acagatgcta aaaatctctt ctgaaaacag     1200

caatccagaa aatgtctcaa gaaccagaaa taaataagga tggtgataga gaggttgaag     1260

aagaaatgaa gaagcatgaa agtaataatg tgggattact agaaaacctg actaatggtg     1320

tcactgctgg caatggtgat aatggattaa ttcctcaaag gaagagcaga acacctgaaa     1380

atcagcaatt tcctgacaac gaaagtgaag agtatcacag aatttgtgaa ttactttctg     1440

actacaaaga aaagcagatg ccaaaatact cttctgaaaa cagcaaccca gaacaagact     1500

taaagctgac atcagaggaa gagtcacaaa ggcttaaagg cagtgaaaat ggccagccag     1560

agaaaagatc tcaagaacca gaaataaata aggatggtga tagagagcta gaaaatttta     1620

tggctatcga agaaatgaag aagcacagaa gtactcatgt cggattccca gaaaacctga     1680

ctaatggtgc cactgctggc aatggtgatg atggattaat tcctccaagg aagagcagaa     1740

cacctgaaag ccagcaattt cctgacactg agaatgaaga gtatcacagt gacgaacaaa     1800

atgatactca gaagcaattt tgtgaagaac agaacactgg aatattacac gatgagattc     1860

tgattcatga agaaaagcag atagaagtgg ttgaaaaaat gaattctgag ctttctctta     1920

gttgtaagaa agaaaaagac atcttgcatg aaaatagtac gttgcgggaa gaaattgcca     1980

tgctaagact ggagctagac acaatgaaac atcagagcca gctaagagaa aagaaatatt     2040

tggaggatat tgaaagtgtg aaaaaaagga atgataatct tttaaaggct ctacaattga     2100

atgagctcac catggatgat gataccgctg tgctcgtcat tgacaac                   2147


<210> 1522
<211> 1826
<212> DNA
<213> Homo sapiens

<400> 1522
gcttgtgggg ttggcagttc tttaagtctg caaataacta cagaacacaa tagagtcctc       60

ctcccttcct ctctctctct ttcttttttt tttttctttt cctgcttcca aacgccttct      120

tcgaggctga agctgggcag gtctccagag gtgcagcagc cacaacaatc ccgcagttca      180

aagttaagca gcagttgcac aacttccagc aactttctca gccggctact aatgagctga      240

aagccaggaa catccgagga gaagagaaag cttccagccc tcctcccttc accctggaaa      300

tccagacacc cccaccccca ccctcagatc actttaagat aatttcttta ttcgtttgcc      360

cgacagacca tggctccctt tggaagaaac ttgctaaaga ctcggcataa aaacagatct      420

ccaactaaag acatggattc agaagagaag gaaattgtgg tttgggtttg ccaagaagag      480

aagcttgtct gtgggctgac taaacgcacc acctctgctg atgtcatcca ggctttgctt      540

gaggaacatg aggctacgtt tggagagaaa cgatttcttc tggggaagcc cagtgattac      600

tgcatcatag agaagtggag aggctccgaa agggttcttc ctccactaac tagaatcctg      660

aagctttgga aagcgtgggg agatgagcag cccaatatgc aatttgtttt ggttaaagca      720

gatgcttttc ttccagttcc tttgtggcgg acagctgaag ccaaattagt gcaaaacaca      780

gaaaaattgt gggagctcag cccagcaaac tacatgaaga ctttaccacc agataaacaa      840

aaaagaatag tcaggaaaac tttccggaaa ctggctaaaa ttaagcagga cacagtttct      900

catgatcgag ataatatgga gacattagtt catctgatca tttcccagga ccatactatt      960

catcagcaag tcaagagaat gaaagagctg gatctggaaa ttgaaaagtg tgaagctaag     1020

ttccatcttg atcgagtaga aaatgatgga gaaaactatg ttcaggatgc atatttaatg     1080

cccagtttca gtgaagttga gcaaaatcta gacttgcagt atgaggaaaa ccagactctg     1140

gaggacctga gcgaaagtga tggaattgaa cagctggaag aacgactgaa atattaccga     1200

atactcattg ataagctctc tgctgaaata gaaaaagagg taaaaagtgt ttgcattgat     1260

ataaatgaag atgcggaagg ggaagctgca agtgaactgg aaagctctaa tttagagagt     1320

gttaagtgtg atttggagaa aagcatgaaa gctggtttga aaattcactc tcatttgagt     1380

ggcatccaga aagagattaa atacagtgac tcattgcttc agatgaaagc aaaagaatat     1440

gaactcctgg ccaaggaatt caattcactt cacattagca acaaagatgg gtgccagtta     1500

aaggaaaaca gagcgaagga atctgaggtt cccagtagca atggggagat tcctcccttt     1560

actcaaagag tatttagcaa ttacacaaat gacacagact cggacactgg tatcagttct     1620

aaccacagtc aggactccga aacaacagta ggagatgtgg tgctgttgtc aacatagttc     1680

caatggctcc tttctgacct gctttcatgt tttaatgttt gtttaattta ataggaaacc     1740

tcattttaaa tataacactc aaaaaaatgt aaatcatatt gtagtattca atagttaata     1800

aaaactcgag aaatgtgttg tttctg                                          1826


<210> 1523
<211> 3974
<212> DNA
<213> Homo sapiens

<400> 1523
gagaggagtg ttttcttgca tccagaaaag acctgagagg cggacgacac ctgtgctccg       60

cagagcagaa cgtgggagga acggcgggat gttaaggagc tcaagaagca gagagtctac      120

ctgcccgacg cgttcgtgga gaggagcagc ggttgctgtt ggaggaggtg ggtgcaagga      180

cggcagatgg catccctgag aggtggtgac tgagactaga tgcgggtgca ggtccatctc      240

cactggtggc tgtggtggct ttggattgtt ggaagaccat caccttcagc aggtctgcac      300

ttgggaacaa tcattctccc ccagcccgag cgtgcctctg ccctctgtat cattgacaga      360

ggctgtatgt ttggaaagag aactttgtga ctgcagaact gacagttgac tctaattctt      420

gctaccaagt ttttccccga cccagtgaaa gagtgttaag acttcgacct aggacacatt      480

gagaaccaag gccaagactg gacagggcca tataactggg cttcaaccat ggctgggact      540

aagaataaga caagagccca ggccaaaact gaaaaaaagg ctgctataca agctaaagct      600

ggagcagaga gggaggctac tggtgttgtt aggcctgtag ccaagaccag ggccaaagca      660

aaagccaaga cagggtctaa gacagatgca gtagcagaga tgaaggcagt gtctaagaac      720

aaggttgttg ctgagacgaa ggaaggagct ctgtcagagc ctaagactct gggcaaagcc      780

atgggagatt tcactcccaa ggctgggaat gagtccacca gctccacatg taaaaatgag      840

gctggtactg atgcctggtt ctgggctggg gaagaggcca ctatcaattc ctggttctgg      900

aatggagaag aggctggtaa tagtttcagc actaagaatg ataaacctga aattggtgcc      960

caggtctgtg ctgaggagtt ggaacctgcg gctggggccg attgcaaacc taggtcaggg     1020

gctgaggagg aggaggaaga gaatgttatt gggaactggt tttgggaagg agatgatact     1080

agttttgacc ctaatcctaa acctgtgagc aggatagtta agcctcagcc tgtgtatgaa     1140

attaatgaaa aaaataggcc caaggactgg tctgaggtaa ctatctggcc caatgcccct     1200

gctgtaactc cagctgtgtt aggatttaga tcccaggcac catctgaggc aagccctcct     1260

tcatatattg ttctggcctc cgctgaagaa aatgcctgtt ctttgcctgt ggcaacagct     1320

tgccgccctt ctaggaacac tcgctcatgc tcacagccta tccctgagtg tcgttttgat     1380

tctgacccct gcatccagac catagatgag attagacgtc aaatcaggat cagggaggta     1440

aatgggatta agccatttgc ttgtccttgc aaaatggaat gctatatgga ttctgaggaa     1500

tttgaaaaac ttgttagctt acttaagtca actactgatc ctcttattca taaaatagca     1560

cggattgcaa tgggtgtcca taatgttcac ccatttgccc aagagtttat taacgaagta     1620

ggtgtagtga cacttattga aagcttgctc agttttcctt cccctgaaat gagaaaaaag     1680

actgtaatta ctctgaatcc tccttctggg gatgaaagac aacgcaaaat tgaattacat     1740

gttaagcata tgtgtaaaga aaccatgtca tttcctttga actcaccggg acagcaatct     1800

ggattaaaga tactaggaca actgactact gattttgtcc atcactacat tgttgccaat     1860

tacttttcag agcttttcca tttgctgtcc tcaggaaatt gcaaaaccag aaatcttgtt     1920

ttgaaactac ttttaaatat gtctgaaaat ccaactgcag ccagagacat gatcaatatg     1980

aaggcattgg cagcattaaa actcatcttt aaccagaaag aggcaaaagc caatcttgtt     2040

agtggtgtgg ccatatttat taacataaag gagcatatca gaaaaggctc aattgtagtt     2100

gttgatcact tgagttataa tacactcatg gccattttca gggaagttaa agagattatt     2160

gaaacaatgt aaaatgagcc agagatagaa cattttaagc catcttcaaa ctctagcagg     2220

ctgtacatta cagtgtacac attatacact gcatctttaa cacagagtca cctgtgacag     2280

gctctaggtt tgagctagac tattttgggg gtatcaaatg aatattatac cttgggctga     2340

aaatgtttga tttttatctt gtctagattg gcatattttt aacattttac ttaagatagc     2400

aaaccagttc gttttaagta agctaacttg ttcattagta tctgtggctt aaaatggcaa     2460

aaaagaaaat atccttgagt ttgtaatcta gttacagaag taaggcatac acacacacaa     2520

agataacagt acctagagag agagtgtgtg tgagtgtgcg tgtctctgtg tgtgcacgtg     2580

cacgctcatg gccaaatgtg cgcactctac ataaaggagg caggagttcc tataggctat     2640

ttaatgtaag agaaactatt tttctcctgt tccagctgta tcagatactc gttccgcaac     2700

acagaaatga ctcagaatct cagacaaaat gtattatttg ttcaatttta attttgctac     2760

tacattcata actcttaaat tgttaggctg tttcatttac atcaaagtta tctcacaaaa     2820

gagaaggcag gaaacgtttt gtgagtgcct attctatgtc aaacactgtg ttggcaccat     2880

attttacaag tttttttcct cttctcacag tgatcttgtg agttagttac ttatattttt     2940

attagaactc attattctgg gtaccctcca atgagaatta gagaggttaa ataccttttc     3000

ctagattccc acagcaggaa ggtggcatag ctgttttgtc tgacaccaga acccatctca     3060

ccacactgct ttacagtctt cctgaaggac attttgaggt gggggggcct tcaaagctca     3120

gagactggtt tgaatggttt aattttgcaa tggatcatgt ccatgccagg tgttacaatt     3180

cttaacttcc tccaaattcg tgtgtccatt agacatttgg ctacatctgg ctggaggtca     3240

ggagaaaatt ctgaggtaaa tagatggatt ttatctggca gtgtcgaaaa tagtaggagc     3300

ctaaaacttt gttcaatgag taagatgtag atttggagtc atcagcaggg gaaacttgtt     3360

agatgtcctt tgtatctttt tctatccatt tgtatttttt ctttcccaaa gagctgaaat     3420

cattttatac cctgaattta aaaggtaatt gcttttttcc tccttgcgaa atcatacctt     3480

aatttttttt tttttttttt ttaccattta tgatttattc tcctatgtgt catatgaaag     3540

gccaaggggc tttatctttt actagtaggc aagcctgggc atttctgcat ttgtgccagc     3600

taacactaca aaatagactt aattagagaa atttagaccc agaattgcag cttcaacaac     3660

acaaaacagg aaagctagaa gaggttgctg tgtcaaccta caagatagtg attcttggaa     3720

gttggtatgg accagaaagc attcccagga catttaggct atggctgagt tctctaagac     3780

tcagggtggg aattataatc cctggtctaa gctgatatga aagtttctat gtgtgaaaat     3840

atggagttat atgctttgag attttctgcc agttaaacta aaacaagatc atactgtaaa     3900

tgtttgtaac ttgcttcccc ccactgtata ctgtaaacat ctttgcatgt caataaatat     3960

gcctctacaa cata                                                       3974


<210> 1524
<211> 3530
<212> DNA
<213> Homo sapiens

<400> 1524
tttccgtggc gacgctatcc gaagtgcggc tgcgcaaggg tgacggcgcg cgagcaaggg       60

ggagggggtg ttttggttct agccgctcgc cgtccttgca ggctctgccg tcggaaagcc      120

gctcattctc gcttcccctt ccctttcccg gctcaagtcc ttcctctctc tttcctttct      180

ttccgcctat cttttttctg ctgccgctcc gggtccgggc cattttccgg gccgggcgca      240

ctaaggtgcg cggccccggg gcccagtata tgacccgccg tcctgctatc cttcgcttcc      300

cccgccccat gtggctgcgg ggccgcggcg gcgctgccca ctatggcccg gaaagtagtt      360

agcaggaagc ggaaagcgcc cgcctcgccg ggagctggga gcgacgctca gggcccgcag      420

tttggctggg atcactcgct tcacaaaagg aaaagacttc ctcctgtgaa gagatcctta      480

gtatactact tgaagaaccg ggaagtcagg ctacagaatg aaaccagcta ctctcgagtg      540

ttgcatggtt atgcagcaca gcaacttccc agtctcctga aggagagaga gtttcacctt      600

gggaccctta ataaagtgtt tgcatctcag tggttgaatc ataggcaagt ggtgtgtggc      660

acaaaatgca acacgctatt tgtcgtagat gtccagacaa gccagatcac caagatcccc      720

attctgaaag accgggagcc tggaggtgtg acccagcagg gctgtggtat ccatgccatc      780

gagctgaatc cttctagaac actgctagcc actggaggag acaaccccaa cagtcttgcc      840

atctatcgac tacctacgct ggatcctgtg tgtgtaggag atgatggaca caaggactgg      900

atcttttcca tcgcatggat cagcgacact atggcagtgt ctggctcacg tgatggttct      960

atgggactct gggaggtgac agatgatgtt ttgaccaaaa gtgatgcgag acacaatgtg     1020

tcacgggtcc ctgtgtatgc acacatcact cacaaggcct taaaggacat ccccaaagaa     1080

gacacaaacc ctgacaactg caaggttcgg gctctggcct tcaacaacaa gaacaaggaa     1140

ctgggagcag tgtctctgga tggctacttt catctctgga aggctgaaaa tacactatct     1200

aagctcctct ccaccaaact gccatattgc cgtgagaatg tgtgtctggc ttatggtagt     1260

gaatggtcag tttatgcagt gggctcccaa gctcatgtct ccttcttgga tccacggcag     1320

ccatcataca acgtcaagtc tgtctgttcc agggagcgag gcagtggaat ccggtcagtg     1380

agtttctacg agcacatcat cactgtggga acagggcagg gctccctgct gttctatgac     1440

atccgagctc agagatttct ggaagagagg ctctcagctt gttatgggtc caagcccaga     1500

ctagcagggg agaatctgaa actaaccact ggcaaaggct ggctgaatca tgatgaaacc     1560

tggaggaatt acttttcaga cattgacttc ttccccaatg ctgtttacac ccactgctac     1620

gactcgtctg gaacgaaact ctttgtggca ggaggtcccc tcccttcagg gctccatgga     1680

aactatgctg ggctctggag ttaatgacaa ctccccaaat gcagagattt acactaactt     1740

ccattctcag tttccttgtt tcttttgatt ttttttttcc taattgtgtg aggctcttgt     1800

gttttagtgg gaacaccaaa gtttgcctat agtttaggca cttaatagga agaagctctg     1860

tacagaaatc tgaaagttgt tttgcttttt gttttcccct ttggtaatca aaattttact     1920

atcttttatt atttctggct tttcaaccaa acattgttgc taatccctat ttttctttaa     1980

gtgacacaca ttctcctgtc tctggcttct tcaggctgaa atgacatagc tcacccttac     2040

ttcactcttg agaggtaggg ctcctttata attacatggt tgctctcaga ctttctgtga     2100

aagtttggga gctgtgtgtg tctgtgtgtg tgtgagagag agatcttgtc tgcgtgtgtg     2160

tgtgtgatct tgtgtgcctg taggtactgt gtgtcactga aattacctgg agtgaggatt     2220

acttgtaatt aaaatattta taaaagaaac aactttattc acagagtcca gctttgggac     2280

tagtctgtat cttgtttttt aagtctaaca acactgataa taggaagtaa aaacagaaag     2340

gaaaagaaat taccactggg aaaatctttt tagttagatt gtaggcttcc tggggcctcc     2400

catgccagga ctgcaaagtg atccagccct acctgtcttc ccacctgtgt gtcccccgtg     2460

tgggaagttg gtgtcacttc cccttcccac cctcacatct gcttagccag tagccacacc     2520

cctaaaacat cagactcacc atccaggtgc agctccagag gctacaaaag gcttcatggg     2580

acttgaatcc ccatcctagc ttctctctcc ttcccctcaa gacctgatct ggttttaagg     2640

ggcctggagc tgggagtctc aagtctgcta agattcacat ccatagcccc catggctttg     2700

aggagaatcc tctctgccat tcttccaatc tccccagtgg gttttgctat tattttctaa     2760

attgggttaa gtctaagaag gtgggggtga gcagggggtt tatctgtgtg tagtgagtgc     2820

ttcatgtgtg gaatattcat tttcttactg cagtgggact tggggttgaa gccacccctc     2880

ctactctgtt ggcttagccc tgagatggtg acaggctggc ctgcagtcag catcattgtg     2940

catgtgacag catcaatgtg attagtaatt tgtctgttcc tcccttgaac tgtctgttta     3000

gtctgaggtt tttaaacttg caggcagctg actgtgatgt ccacttgttc cctgattttt     3060

acacatcatg tcaaagataa cagctgttcc cacccaccag ttcctctaag cacatactct     3120

gcttttctgt caacatccca ttttggggaa aggaaaagtc atatttattc ctgcacccca     3180

gttttttaac ttgttctccc agttgtcccc ctcttctctg ggtgtaagaa gggaaattgg     3240

aaaaaaaatt atatatatat tctcctttta atggtggggg gctactggag aggagagaca     3300

gcaagtccac cctaacttgt tacacagcac ataccacagg ttctggaatt ctcatcttcg     3360

aacctagaga aataggtgct ataaacaggg aattaagcaa aatgctggat gctatagatc     3420

ttttaattgt cttaattttt tttctattat taaactacag gctgtagatt tcttagttct     3480

cacagaactt ctatcatttt aaactgactt gtatatttaa aaaaaaaatc                3530


<210> 1525
<211> 3788
<212> DNA
<213> Homo sapiens

<400> 1525
atcccggctc ctgcatccag tcgccattcg ggaggccgct gcgctgcagg gcctcgcgga       60

gccgcccgcg accgcgagcc gggccctccg cgcggtccat cgcccactgg acgccgcccg      120

cggccggacc ggttcaactt ctcatctttg ttcttcttca tatactatag gctgtttgct      180

gtggtttagt caaaaagcca tgtagaatgc ctgccttttg aagaccactt ttaaggtgtc      240

tagtaagaca gcagcagtat tgaaagtttt taaagaatat aaccgtgtgt gttggtaaca      300

gacagaagaa tggaagcatt ccaggaactt cgtaaaccat cagcacgttt ggagtgtgac      360

cattgcagtt tcagaggcac agactatgaa aatgtacaaa tccatatggg taccatccat      420

ccagaatttt gtgatgaaat ggatgctggt gggctaggca aaatgatatt ttaccagaaa      480

agtgcaaagt tatttcactg ccataaatgc ttcttcacca gcaagatgta ctctaatgta      540

tactatcaca tcacatccaa acatgcatcc ccagacaaat ggaatgataa accaaaaaat      600

cagttgaaca aagaaacaga tcctgtgaaa agccctcctc ttcctgaaca ccagaaaata      660

ccctgcaatt cagcagaacc aaaatccata cctgcccttt caatggaaac acagaaactt      720

ggttcagttt tgtctccaga atcgccaaaa cctactcctc ttactcccct ggagcctcag      780

aaacctggct ctgttgtttc tcctgagcta cagacacctc ttccttctcc tgagccttca      840

aaacctgcct ctgtttcttc tcctgaacct ccaaaatcag tccctgtttg tgagtctcag      900

aaacttgccc ctgttccttc tccagaacca cagaaacctg cccctgtatc tcctgagtca      960

gtaaaggcta ctcttagtaa tcccaaaccc cagaagcagt ctcatttccc ggaaacattg     1020

gggccacctt cagcctcatc tccagagtca ccagttctag ctgcttcccc agaaccttgg     1080

ggaccatccc cagctgcatc tccagaatct cggaagtcag cccggactac ctcccctgag     1140

ccaaggaagc catccccttc agagtctcct gaaccttgga agccgttccc tgctgtctcc     1200

ccagagccta ggagaccagc ccccgctgtg tcaccaggct cttggaaacc agggccacct     1260

gggtccccta ggccttggaa atccaatcct tcagcatcat caggaccttg gaagccagct     1320

aaacctgctc catctgtgtc tcctggacct tggaaaccaa ttccttctgt atctcctgga     1380

ccttggaaac caactccatc tgtgtcttct gcatcctgga aatcttcatc agtctcaccc     1440

agctcctgga agtctccccc tgcatctcct gagtcatgga agtctggccc accagaactc     1500

cgaaagacag ctcccacgtt gtctcctgaa cattggaagg cagttccccc agtgtctcca     1560

gagcttcgca aacccggccc accactatcc ccagagatcc gtagtccagc aggatctcca     1620

gagctcagaa aaccctcagg gtcaccagat ctttggaagc tttctcctga tcagcggaaa     1680

acttctcctg cttcacttga tttccctgag tcccagaaaa gttcccgtgg tggttctcct     1740

gatctctgga agtcttcctt ttttattgag cctcagaaac ctgtcttccc tgagacccga     1800

aaaccaggtc cttctgggcc atctgagtcc cccaaagcag cctcagatat ctggaagcct     1860

gttctctcta tcgatactga gcctagaaaa cctgccctgt ttcccgagcc tgccaaaaca     1920

gcccctcctg cttctccaga agcacgcaaa cgtgcccttt ttccagagcc ccggaagcat     1980

gcccttttcc ctgaactccc caaatctgct ctattctcag aatcacagaa ggctgttgag     2040

cttggtgatg aactacaaat agatgccata gatgatcaaa aatgtgatat tttggttcag     2100

gaagaacttc tagcttcacc taagaaactc ttagaagata ctttatttcc ttcctcaaag     2160

aagctcaaga aagacaacca agagagctca gacgctgagc ttagtagtag tgagtacata     2220

aaaacagatt tggatgcgat ggatattaag ggccaggaat caagcagtga tcaagagcag     2280

gttgatgtgg aatccattga ttttagcaaa gagaacaaaa tggacatgac tagtccagag     2340

cagtctagaa atgtgctaca gtttactgaa gaaaaagaag cttttatctc tgaagaggag     2400

attgcaaaat acatgaagcg tggaaaagga aagtattatt gcaaaatttg ttgctgtcgt     2460

gctatgaaaa aaggtgctgt tttgcatcat ttggttaata agcataatgt tcatagccct     2520

tacaaatgca caatctgtgg aaaggctttt cttttggaat ctctccttaa aaatcatgta     2580

gcagcccatg ggcaaagttt acttaaatgt ccacgttgta attttgaatc aaatttccca     2640

agaggtttta agaaacattt aactcattgt caaagccggc ataatgaaga ggcaaataaa     2700

aagctaatgg aagctcttga accgccactg gaggagcagc aaatttgata acacagtgtg     2760

aatatttgtt ctacaaaggt gtttgttgga accattcttt gtaagtatag cttatcagat     2820

agcatagttg gatcagtaga tgacatgtat ggtgtaccgt gtttcactgt ctcagttgtg     2880

ttactaagaa tgagcatttg atcatttttt tctggtctct gtctatgtga ctatcttgta     2940

agtcaataaa tttctgtata gtccagatgg attaaacttc tcatttcttt taaatatgta     3000

tgaataataa tacaaggaag taggcattcc atttaataat caagagcaag ttgtactcaa     3060

agcattcagt taaagtgtat ctgtgtgtgg aactaatttc agacaataga aaatattagt     3120

tgaaatgttt aagaattagg catgaaaaat aaatttgaga aattttgttt ccttacatgt     3180

atttttaaat cataagagtt attttctatc tgatgtaaaa ttagtttata aatcttaatc     3240

agcttctaga tgtttattag cttttatgtc atgaaatgtt ggagtctcag ggttgctgat     3300

tttctgctaa tgggaaaaat tgactaagtc tttaaaatag tttgcagcct tctcccacag     3360

gagacaagtg aaagataagt gtgattttag atctttcttg tccatagttg ttttcagtgg     3420

agtcttccat tctgtatctt accctaagat ctggttcttc cctccccatc cccacccccc     3480

acccaccgcc tgccagctca cactaataga tgattcttaa ttgccaaatg tgttagagtt     3540

tgtatatcct actcctgggc cttacatgtc gcctgttggg gcttaagacc aggttgataa     3600

gtaggaactg aaagtcttcc agattcacag tagaaaattt tatagacatt tctgttaaag     3660

aaatatatcg attttatgtt tttcaattat gttactgtaa ataccttgta cctgttcatg     3720

gattatttta ttctaaaata ttttgtcaaa tgtgtatcaa ccaaattaaa aagaaaggtt     3780

ttcatgtc                                                              3788


<210> 1526
<211> 4823
<212> DNA
<213> Homo sapiens

<400> 1526
gagaacggtg gccggacgga gagactgcgg gtctgaggga ctggcgggcg ggcgggccga       60

gcggcgccgc cgaggccggg ctgggccgag cccaggagcg cccgggatgt agcgggccac      120

cctgccgatg ccacagcgcc cggccgcggg cggagccgga gccggagcct ggggaggcgg      180

cgggggccca gagcgcagcc cgcgcccccc gcgcggagcc aggcccgctg ccgtccccgc      240

cgcccgggcc cccggcatgc agccccggct gcggaggtga cactcacgga ccttagccac      300

cgccgccgcc atcgccacca tggacgaaca ggaggcattg aactcaatca tgaacgatct      360

ggtggccctc cagatgaacc gacgtcaccg gatgcctgga tatgagacca tgaagaacaa      420

agacacaggt cactcaaata ggcagaaaaa acacaacagc agcagctcag cccttctgaa      480

cagccccaca gtaacaacaa gctcatgtgc aggggccagt gagaaaaaga aatttttgag      540

tgacgtcaga atcaagttcg agcacaacgg ggagaggcga attatagcgt tcagccggcc      600

tgtgaaatat gaagatgtgg agcacaaggt gacaacagta tttggacaac ctcttgatct      660

acattacatg aacaatgagc tctccatcct gctgaaaaac caagatgatc ttgataaagc      720

aattgacatt ttagatagaa gctcaagcat gaaaagcctt aggatattgc tgttgtccca      780

ggacagaaac cataacagtt cctctcccca ctctggggtg tccagacagg tgcggatcaa      840

ggcttcccag tccgcagggg atataaatac tatctaccag ccccccgagc ccagaagcag      900

gcacctctct gtcagctccc agaaccctgg ccgaagctca cctccccctg gctatgttcc      960

tgagcggcag cagcacattg cccggcaggg gtcctacacc agcatcaaca gtgaggggga     1020

gttcatccca gagaccagcg agcagtgcat gctggatccc ctgagcagtg cagaaaattc     1080

cttgtctgga agctgccaat ccttggacag gtcagcagac agcccatcct tccggaaatc     1140

acgaatgtcc cgtgcccaga gcttccctga caacagacag gaatactcag atcgggaaac     1200

tcagctttat gacaaagggg tcaaaggtgg aacctacccc cggcgctacc acgtgtctgt     1260

gcaccacaag gactacagtg atggcagaag aacatttccc cgaatacggc gtcatcaagg     1320

caacttgttc accctggtgc cctccagccg ctccctgagc acaaatggcg agaacatggg     1380

tctggctgtg caatacctgg acccccgtgg gcgcctgcgg agtgcggaca gcgagaatgc     1440

cctctctgtg caggagagga atgtgccaac caagtctccc agtgccccca tcaactggcg     1500

ccggggaaag ctcctgggcc agggtgcctt cggcagggtc tatttgtgct atgacgtgga     1560

cacgggacgt gaacttgctt ccaagcaggt ccaatttgat ccagacagtc ctgagacaag     1620

caaggaggtg agtgctctgg agtgcgagat ccagttgcta aagaacttgc agcatgagcg     1680

catcgtgcag tactatggct gtctgcggga ccgcgctgag aagaccctga ccatcttcat     1740

ggagtacatg ccagggggct cggtgaaaga ccagttgaag gcttacggtg ctctgacaga     1800

gagcgtgacc cgaaagtaca cgcggcagat cctggagggc atgtcctacc tgcacagcaa     1860

catgattgtt caccgggaca ttaagggagc caacatcctc cgagactctg ctgggaatgt     1920

aaagctgggg gactttgggg ccagcaaacg cctgcagacg atctgtatgt cggggacggg     1980

catgcgctcc gtcactggca caccctactg gatgagccct gaggtgatca gcggcgaggg     2040

ctatggaagg aaagcagacg tgtggagcct gggctgcact gtggtggaga tgctgacaga     2100

gaaaccaccg tgggcagagt atgaagctat ggccgccatc ttcaagattg ccacccagcc     2160

caccaatcct cagctgccct cccacatctc tgaacatggc cgggacttcc tgaggcgcat     2220

ttttgtggag gctcgccaga gaccttcagc tgaggagctg ctcacacacc actttgcaca     2280

gctcatgtac tgagctctca cggccacaca gctgccggtc gccctttgct gcatggcagg     2340

gggctgctgc tgggctcagt gaagttgctg cttctcccag gcaaggctgt ggaccatgga     2400

gtggcagccc agccagcgtc ggtctgtgcc ccttccgcca ctggggctca gagccggggt     2460

ggggtggctg cagcctcagg actgggagcc cccagcctgt cagatccagg agctccagtg     2520

tcctgagctc agcgtggagg ggtaggggct gggaacagtg tgcaaggcag ccgtgggccc     2580

caccctcggg gatgtgtcct gacactgcaa ttggcaccga agcccagagg gtctgggggc     2640

acaagactga cgccagggta tgaagagtgt tattttcatt caaagtgtta ttttgttttt     2700

ccttccaatg tctggagacc accagggcat ctctgggctg gatgagctcc cacaagcctg     2760

agggaaaggc cagcactcgc tagcagtggc aggcagaggc ccaggctgcc gtcccctaga     2820

gtcccaggtt ggctctgcca gtcctgtcct ttaccaaaga tgaatgaagc aaatgtcatg     2880

ctgccttatt cagggaagga ggagcctgtc ctgcctgtgg ccatgaccct gcctctccca     2940

ggcaggggcc cgcgatgtgg aactgctgcc actgaggggg gatccagttt tgtcaatgca     3000

gttgtctctg ttttacaagt tggagtcact cttatgctgt acccagtttc taaactggag     3060

actgtgtgtg ccctctgggc tctgagtacc cctgctttgg gcttgggcct aggctgcatt     3120

gaaaagagct gaaggttgtg gcctttgcgc tcctggccca gcctttgttc cccactggag     3180

cagaagggga gatggacgac acggtcgggg catctggcct ggccagtgcc ctgatcccag     3240

agagcccgag gaggtgtctc aggctgcctg agtcgtgacc tgctaggcca gagcccactc     3300

catctggtag aagggaaagc ccatatgcta ccaccagctg tgtccaaaac cgccagctct     3360

gttcttcctc agccagcctc gcccatcccc ttgaggtctc agcccctttc ccttgtagct     3420

cctcccctgg agggggaatg gcagcagggg ttggggaaac agcatctcca agcagcttag     3480

agttggccat atttacctca gcctgggcgc tggtcctttc ttccggcccc tcccctccaa     3540

aatgtgccta ttgctagagc tcctccctct caacacccag tttccttggg agttgtcatt     3600

aaaggaaaaa aaaaaaaaaa aaagccagtg cccagggatg ggcatctcca gggagctggg     3660

gattagtgcc aggcagccct gccagccatg cctacatccc catgggcaca gaacaagcca     3720

aagccttcgt tgtatgttga cgatgcactt ttatgaatgt agtttctatc gctgttttta     3780

gccttttcac atcatgtaat gtgaggcctt gtacttgtta atttatatct cagatcatat     3840

ttgatggttt ttatatatat caattctaga ctgttacagg tgacggacgc ctcaagagag     3900

agaagagaaa atgaaagcag ctggttttgc agaagtgtgt gtcgcatgcg ccagttgggc     3960

ctggaccctc ctgtgtccat ccctgttccc ccaggggctc tatcagcccc tgtaccccac     4020

actgccctct gaagacaaca caggctcctg cttccacctc ggcccttgcc cagggtgggg     4080

cctggccctc atcttgacca aagctgctgt gtggcagctc ggcctctcta cgaccccatc     4140

ttggtggctg cacactcttc ctggcccgca cccccatccc cagtccctgt tccccaagag     4200

gatacagagc acggtgctgg ctgactcaac tgtgcgtccc aggttcaggg tcttacagag     4260

ctccaccccc tggggtctta cctcactggg aatgtgtttt gaaaatgaat ttgaagacaa     4320

gccaacaaac cctgcactcc aaaaaagcaa aacagaccct aatttttttg tgccaaaaac     4380

tgtggacatg ctggctcagc atcctcagga ccaagttgtt gcttaattta ttgtttttta     4440

ataactaatc cagataaaaa gttgtggggc ttcagggtga cctgggccca aaggttctga     4500

agggcagttc ctggcagccc caggcttgct gtgggaaggg gccgtgccgt cactttctca     4560

tcattccatg gggtgtgtct gcctgggcca actctgcatg gagaggccag ggctggggac     4620

agtccgcact ctgccaccct cctgcccctt ccacccaccc cagctctatg tctgtgtctg     4680

aattgtggat cgtgcagcca tggttattgt ggaactgtgg aacctgcagc catagttatt     4740

tgactatatc ttgaccgagg gcttgcagtg caaagccagg ccagtgttgc gcattactta     4800

caataaaagg gatcatttat atc                                             4823


<210> 1527
<211> 4503
<212> DNA
<213> Homo sapiens

<400> 1527
cgagggaaga ggccggaggg agatcgcgga ggggaggggg cgggaggggg gtggggtatc       60

ctgagtcgtc cgtggtccgg agtctggaag gccctagagc ggcgccagtc gacccgcctc      120

gccacaactt gcccagacca gacacgtttc atcctgcgcc ctgcaagaag gagccggcct      180

gcctctctcc gctttgctgc tcctcggcct ccgcgggccc ggcccgcgtc agcagcgacc      240

ctggggtctg ggtcccctgt gtcgcccccg cccgcctgca gcgcccggca cccgcccagg      300

agcgcgcagc tggggttcta gggacgtata cttgagcaag agagaccaca gctcttgttc      360

ccgctgatcc tgcagcccag tggatggagt ccagaatcta cagacctgcc aggaaagaaa      420

aaaaaattcc tgatgtctgg tccaagcagg aattccccgg tggattgggg aatgtctggc      480

ttttcctcag cttattgatc tctgtggtaa ccactggagg cccccagaag acccatagaa      540

atgagaggcc tgaggtctac aagtcgctgc tagaaatatt ttagcctctc caaagcccag      600

aatgcagccc cgacccaagt ttgtaagggt tctgggtgca cgctgaccct gcgcgggcag      660

acgcgccctt tgctccaggt ccggacctgg gcgctgctat agcaacgtcc tggacgccca      720

gaccttaggc cgccgccgcc gcggaagcga ggaacccggc cttctcccgc tcctgagggc      780

tgtggcggcg gcggcccggg aggcggccca ggctgggtaa agaccgcccg gctcctccta      840

tgcaagctga ggcagcggat tggttttcaa gcatgccctt ccagaagcat gtctactacc      900

cgctcgccag cggcccagag gggcccgacg tcgctgtggc cgccgccgcc gcgggtgcgg      960

cctccatggc ctgtgcgccc cccagcgcgg cttcggggcc cctgcccttc ttccagttca     1020

ggccgcggct ggagagtgtg gactggcggc ggctgagcgc catcgacgtg gacaaggtgg     1080

cgggggctgt ggacgtgctg acgctgcagg agaacatcat gaacatcacc ttctgcaagc     1140

tggaagacga gaagtgccca cactgccagt cgggggtgga cccggtgctg ctgaagctca     1200

tccgtctggc gcagttcacc atcgagtact tgctgcactc acaagagttc ctcacctcgc     1260

agctgcacac cctggaggag cggctgcgcc tgagccactg cgacggcgag cagagcaaga     1320

agctgctcac caagcaggcg ggggagatca agacgctcaa ggaagagtgc aaacgccgga     1380

agaagatgat ctccacccag cagctgatga tcgaggccaa agccaactat taccagtgcc     1440

atttttgtga caaggccttt atgaaccaag cttttctaca aagtcacatt caacgccgcc     1500

acactgaaga aaattctcat tttgagtatc agaaaaatgc acagattgag aagctccgga     1560

gtgagatcgt cgtattgaag gaagagctgc agctcaccag gtctgagcta gaggctgcac     1620

accatgccag tgcagtcaga ttctccaagg aatatgaaat gcagaaaaca aaagaggaag     1680

actttttgaa gttatttgac aggtggaaag aagaagaaaa ggagaaacta gttgatgaaa     1740

tggaaaaagt caaggagatg tttatgaagg aatttaaaga attaacttcg aagaattcag     1800

cattagaata tcaactgtca gaaatccaga agtccaatat gcagatcaag tccaacatag     1860

gcacattaaa agatgcacac gagtttaaag aagaccgttc tccatatccc caggatttcc     1920

ataatgtcat gcagcttctt gatagtcagg aaagcaaatg gacagctcga gttcaagcta     1980

ttcatcaaga acacaagaaa gagaagggtc ggctcctgtc acatatagag aaacttcgaa     2040

cctcaatgat agatgatcta aatgcaagca atgttttcta taagaaaagg atagaagagc     2100

tagggcagag actccaggag cagaatgagc tgattataac tcagagacag cagattaaag     2160

actttacctg taatccatta aacagtatca gtgaacccaa agtgaatgcc ccagccctgc     2220

acactttgga aactaaatca agtctgccaa tggtgcatga acaggcattc tcgtcgcaca     2280

tactggaacc aatagaagaa ctttcagagg aagaaaaagg aagggaaaat gaacagaaat     2340

taaataacaa caaaatgcat ttaaggaaag ctttgaagag taactcctcc ctcactaagg     2400

gactaagaac aatggtggag cagaacttga tggagaaact ggaaaccttg gggattaatg     2460

cagatatacg tggcatttca agtgatcagt tgcatagagt actaaaaagt gtggaatcag     2520

aaagacataa gcaagaaaga gaaataccta actttcatca aattcgagaa ttccttgaac     2580

atcaagtcag ctgtaaaatt gaggagaaag cactactctc ttcagatcag tgcagtgttt     2640

ctcaaatgga taccctttca actggagaag tacccaaaat gatacaactt ccttccaaaa     2700

acagacaact gattagacaa aaagctgttt ctactgatag gacatctgtt ccaaaaatta     2760

agaaaaatgt catggaagat ccttttccca gaaagtcttc aactattacg acccctcctt     2820

ttagttcaga ggaggagcag gaggacgacg acctcatccg ggcatacgca tccccaggcc     2880

cacttcctgt gccgccacca caaaacaagg gcagcttcgg gaagaacaca gtgaaaagtg     2940

acgcggacgg gaccgaggga agcgaaatcg aggacactga tgattctccc aagcccgcag     3000

gagtcgccgt taaaacacct actgaaaaag ttgaaaagat gtttccacat cgcaaaaatg     3060

tgaacaaacc agtcggtgga actaatgtcc ctgagatgtt tatcaaaaaa gaagaattac     3120

aagaactaaa gtgtgcggat gtggaggatg aagactggga catatcatcc ctagaggaag     3180

agatatcttt gggaaaaaaa tctgggaaag aacagaagga acctccacct gcgaaaaatg     3240

aaccacattt tgctcatgtg ctaaatgcct ggggcgcatt taatcctaag gggccaaagg     3300

gagaaggact tcaagaaaat gaatcaagca cattaaaaag cagcttagta actgtgactg     3360

attggagcga cacttcagat gtctaattcc acatgtcaga agattattcc agaagccagc     3420

agtatttcag tatcacagtg tttcagtaat ttgcctccat gattctagtg cttctgcctt     3480

accgtgtttc ccacagcaac acagagactg attcaaagaa caatggtctc tttaatggca     3540

cccaatacag tattgaaaat cagatcatca acagtatttc gaagcatgta aaggtgttta     3600

agacttccgc tgctgcttaa aaataacatg tcattgaagt cataaaaagt tttttcttca     3660

gaaaggtact ctagtgttaa gtgtattttt ttcaactaat tttttagtga atttttttta     3720

aacttacagc atgttttggt ttgaattact aaaactttaa aaaatatttt tcttatgtat     3780

gctgtcgtat cgtaggcgtt tatattataa aattctgtta gtagtcttaa aattgaattg     3840

gtggaaccac taatccttaa aagttagtct ggttattttt catatagaag taagtttaat     3900

ccgagtgtgg tggtgttcac ctttaatccc agctacttgg gaggctgagg tgggaggata     3960

acttgagcac aggagttcaa gaccagcgtg ggcaatatag caagactcca cccctccaca     4020

ccccaaaaaa gtaagtttag gattagaata tagctaggtc caatgttaaa tacattttcc     4080

tggagtacat ttgtcacatt cagctttgag ccactgtaag catgttacta ttaaatggtt     4140

ggttatttta tatagcatat tctttatctt ggatatttta tgaataaagt atagttattt     4200

taagtgccaa ttaatttatc agactaaata gaaaatattt gagccattac tgaattcaca     4260

tatgtatgtt tttttttact atttaaaata cccaacatgt attatgaaat acctcaaaag     4320

taatttagtt acattcttaa acaatgacat tgtcgaaaga aagttcttat aagctgtttt     4380

ttgcattttt ataacttggt tatactatat tctgtttcca agtaaccttt taactaaaag     4440

atttgttggg ttttagatct cttttcattt gtcaaccttt tcagtaaagc cctctgttac     4500

atc                                                                   4503


<210> 1528
<211> 6458
<212> DNA
<213> Homo sapiens

<400> 1528
cggcgtctct ctcccccgcg ccagctcccg tacacggagc cgcattcctt ggccccccca       60

cccccctccc tcggggcccc cccgcccccc tcgggaaaaa aatccacccc gaatcactcg      120

aacccgaggg aggcttcctt tcacccttgg ggagacgagc tttcaacggt tacctcttct      180

tcgtctcccc ccaagccccc gtcccctccc cctgctccca cccccttctg gcgccgggtg      240

taaggtccct ttaaggcgac ggcgccttcc tcgggtcaga ctaccggcgg cgacgaccac      300

aggagcatgg cggacaccga cctgttcatg gaatgtgagg aggaggagtt ggagccatgg      360

cagaaaatca gtgatgtcat tgaggactct gtagttgaag attataattc agtggataaa      420

actaccacag ctggcaatcc tttggtccag caaggtggac agccactcat cctgacccag      480

aatccagccc caggtctggg cacaatggtt actcaaccag tattgaggcc tgttcaggtc      540

atgcagaatg ccaatcatgt gactagttcc cctgtggcct cacaaccaat atttatcact      600

acgcagggat ttcctgtaag gaatgtccgg cctgtacaaa atgcaatgaa tcaggttggg      660

attgtgctga acgtacagca aggccaaacg gttagaccaa ttacactagt tccagcccca      720

ggtacccagt ttgttaagcc gacagttgga gttccacaag tgttctccca gatgacccct      780

gtgaggccag gctccacaat gcctgtgagg cccaccacca acaccttcac caccgtcatc      840

ccggccactc ttaccattcg aagcaccgtc ccacagtccc agtcccagca gaccaagtcc      900

actcccagca cttctaccac tcccactgcc acacagccaa cctcactggg gcaactagct      960

gttcagtctc caggccagtc aaaccagacc acgaatccca agctagctcc ctccttcccc     1020

tctccacctg cagtgagcat tgccagcttt gtcactgtga agcgacctgg tgttacaggc     1080

gaaaatagca atgaagtggc caaattggtg aataccctta acaccatccc ttccctgggc     1140

cagagtcctg ggccagtggt ggtgtccaac aacagctctg ctcatggctc tcaaagaacc     1200

agcggacctg agtcttcaat gaaagtgacc tcttccatcc cagtatttga cctccaggat     1260

ggtggacgga aaatatgtcc acgatgtaat gctcaatttc gtgttactga agctttgaga     1320

ggtcacatgt gttactgttg cccagaaatg gttgaatacc agaagaaagg aaagtccctg     1380

gattcagaac ccagtgtccc atcagcagca aagcccccat cccctgagaa aacagctcct     1440

gttgcttcca caccctcttc tacacctatt cctgctctgt caccgcctac caaagtacca     1500

gaaccaaatg agaacgtggg cgatgccgtc cagaccaaac tcattatgct tgtagatgac     1560

ttctactatg gacgggatgg tggcaaagta gcccagctca caaatttccc taaggtcgcc     1620

acatctttcc gatgcccaca ttgtaccaaa aggctaaaaa acaatattcg attcatgaac     1680

catatgaaac accacgtaga actcgatcag cagaacggtg aggtagatgg tcacactatc     1740

tgccagcact gttaccgcca gttttccact cccttccagc ttcagtgcca cttggaaaat     1800

gttcatagtc cctatgaatc tactaccaag tgcaagatct gtgaatgggc gtttgaaagt     1860

gagccactat ttctccagca tatgaaggat actcataagc ctggagagat gccttatgtt     1920

tgccaggtgt gtcaatatcg ctcctcactc tactctgagg tagatgtcca ttttcggatg     1980

atccatgagg atacccggca tctgctctgc ccttattgcc tgaaggtctt caaaaatggc     2040

aatgcattcc aacagcatta catgaggcac cagaagagaa atgtttatca ctgcaacaaa     2100

tgccggctgc agtttctctt tgccaaggac aaaattgaac acaagcttca acaccataaa     2160

accttccgta aacccaagca gctggagggc ttgaaaccag gcaccaaggt gacaatccgg     2220

gcttcccgag ggcagccacg aactgttcct gtatcctcta atgatacacc tcccagcgcc     2280

ttgcaggagg cagcaccgct gacctcctca atggaccctc tgcctgtctt cctttatccc     2340

cctgtccagc gcagcatcca gaagagagct gttaggaaaa tgagtgtcat gggccggcag     2400

acatgcctgg agtgcagctt cgagatccca gacttcccta atcatttccc tacttacgta     2460

cactgctctc tgtgtcgcta tagcacctgc tgttctcgag cttatgccaa ccacatgatc     2520

aacaatcatg ttccacggaa gagccccaag tatttggctt tgtttaaaaa ttctgtgagt     2580

ggaatcaagc tggcctgcac ttcatgtacc tttgttacct ctgtgggcga tgctatggcc     2640

aagcatttgg tattcaaccc ctctcacaga tccagcagca tcctgccacg gggactcact     2700

tggatagctc actcaaggca tggccagact cgtgaccgag tgcatgaccg gaacgtgaag     2760

aatatgtacc ctcctccttc cttccccact aacaaagctg ccactgtgaa atctgcgggg     2820

gccaccccag ctgagcctga agagctacta actcccttag ccccagcact cccatcacca     2880

gcctcaactg caaccccacc accaaccccc actcacccgc aggctttagc ccttccaccg     2940

ctggctacag agggagccga atgtctgaat gttgatgatc aggatgaagg gagcccagtc     3000

acccaagaac ctgagctagc atcaggtggt ggtggtagtg gtggagttgg caaaaaggag     3060

cagctgtctg tgaagaagct tcgagtagta ctgtttgctc tatgctgcaa tacagaacag     3120

gcagctgaac acttccgaaa tccccagcga cgtattcgcc gttggcttcg acgtttccag     3180

gcctcccagg gggagaatct agagggcaaa tatctgagct ttgaggcaga agagaaactg     3240

gctgagtggg tgctaaccca gcgcgaacaa cagctacctg taaatgagga gaccttgttc     3300

cagaaggcca ccaaaatagg acgttctttg gaaggggggt ttaagatctc ctatgagtgg     3360

gctgtgcgtt tcatgctgcg gcaccacctg actccccatg cccggcgagc tgtggcccac     3420

accctaccta aggatgtagc agagaatgca ggactcttca ttgattttgt acaacggcag     3480

attcacaacc aggacttacc cttgtctatg attgtggcta ttgatgagat ctctttgttc     3540

ctggatacag aggtgctgag cagtgatgat cgaaaggaga atgccctgca gacagtgggc     3600

acaggggaac cttggtgtga tgtagtccta gccattctgg cagatggcac tgtccttccc     3660

accctggttt tctacagagg gcagatggat cagcctgcta acatgccaga ctccatattg     3720

ctagaggcaa aggagagtgg ctacagtgat gacgagatca tggagctgtg gtcaactcga     3780

gtgtggcaga agcacacagc ttgccagcgc agcaaaggca tgcttgtgat ggactgtcat     3840

cgcactcact tgtcagaaga ggtactggct atgcttagtg cctctagcac tttgcctgca     3900

gtggtcccag caggctgtag ctccaaaatt cagccattag atgtatgcat caaaagaact     3960

gtcaagaact tcctgcataa aaaatggaag gaacaggctc gggaaatggc agatactgca     4020

tgtgattctg atgtcctgct tcagctggtg cttgtctggc tgggtgaagt gctaggtgtc     4080

attggggact gtccagagct agttcagcgc tccttcctgg tggctagtgt tctgcctggc     4140

cccgatggca acattaactc acctacaaga aatgctgaca tgcaggagga gctaattgcc     4200

tccctagagg agcaactgaa gctgagtggg gaacattctg agtcttccac tccacgaccc     4260

agatcatctc ctgaagagac aattgagcct gaaagtcttc accagctctt tgagggtgaa     4320

agtgagaccg agtctttcta tggctttgaa gaagctgacc tagatctgat ggagatttga     4380

gtgttggggt catgaggggg tgtggagtga gggtgggaac atgtgaggga gggtaaaggg     4440

gcttagggaa aagggggcat accaggtggg gtatttggtt tctatttttt aattttatac     4500

caccactccc ccctgaagtt gacttacact tccctgtgga tttgtggatt aattaggaaa     4560

accaatagta atcacgtctg agccaaggag ctggcccatt ggtcattcac ttctgctaaa     4620

aacaggtttt tgtgactttt ttttttttta aatttaaatc actgtgtttg gtatttttct     4680

gacaaaatta agaaaaagaa aaaaaattat ttgtgggcaa atgttaaatt tttttgtttc     4740

cccttttacc tcaattgtat catagtactg ggtttttttg tttgttttat tgtgtggcca     4800

atgtctttgg gcatgatgct atctaatcat tgttaatgtg agaacatttc tgaagatggg     4860

aaagacaaat tatgtagctc acaaactggt ttattatata tatggataaa aaactttttt     4920

cattgtggtc ttaacacttt tatataaaaa tgaaaatgga aaaaaagtcc cactgaactc     4980

tctcttcctt ctccttttct ttccttccct ctccagagat gttggtttct acagcaaccc     5040

tagatataaa attgtggctt taaaaatgca tgaaaccacc tttaattatc cagaatgaat     5100

agatttgtct tttcctcacc accttccctc caaaacatga cataaacaat attttttgca     5160

cttgtgatcc ttggcccctt tccccattct caacaccatc catccctctg gacaaaggat     5220

catacaggtg ttattagcaa gcaagagata ctgaagcgat caaacagttt tagggtggaa     5280

gccattccca gtttgagtct tcatcctgta agcccccagg ggcagtccct gctttactga     5340

acttcatcct gttagatgga gagcatgcct gtttaaggga ttactggtcc tacagccagg     5400

agctaattgt tcaagaagtg ttgaacttta aaaagacaag accacttgtt gaaatccagc     5460

gtgctctgtg gctttcccct atttctctta atacttaggg aagaatctga caggaagaag     5520

cgcacagggg tgtgcacaaa gaaaatgaca tgaatcttta tttttcactg ccagcttcaa     5580

ggaaagaaaa ttttttctac aatttgcatg agggattttt ttaattgtat gtactcatgg     5640

ttgtaaacca aaacgtactg taccgtacag agaaaaggag caaaaaacca agtcttctgt     5700

ttatcctgag gctttccaca atgttcccct cctgtgagcc aaggaggcaa actgcacaag     5760

cttgtaaatg gttcgtcttt aaaatgtaca taagtggaac atttaataaa atgaggggaa     5820

atggatttat aaacttgttt tttttctagg tgaccctgtt taataggctt tcacagactg     5880

gggaatgctc aagatgtgat gggcctggtg gtacaggtgt gacatttgtt accacccatt     5940

tctcccaccc caccctgctt ttttgtttgt ttgttttttc atcccccagc acactataat     6000

atagtgaact ggaaaagtcc cttccagaaa cagcttggcc agctttgtga acctttgaca     6060

tctgaaaaca accaaggatc catctgggct tctcttcccc agctttttgc ctgatgccat     6120

tttattgaca gacaatggac tttgaagtca gcctttgcct ttgagaaagt tcaagaacta     6180

tggttggtca cgtctatcta caacctaatc ctactctttg gtagtctctg cagcagccac     6240

agccttagca gagctggggt tcctgtcttc tgcacacgat tgactttctt gatgggtaat     6300

tttttttaag attataccaa cagtggatca gctgggtttt ggccaggaag ttgtctttgt     6360

ggactctgcc tgcatggctt agtagtagaa ggaaattttt ttttggtttt gttttttata     6420

attcagttta atcaataaac atgtatttat tgactgtt                             6458


<210> 1529
<211> 4684
<212> DNA
<213> Homo sapiens

<400> 1529
aatccatccg catggctttt tgctctagtt cctcagatct ttctgcgcta gctgcactcc       60

caagcccagg cttagatcta ccctaatcta gtcccagccc cgacctcatg gacactggct      120

gcaaaactta ccgccttgca acacctggat ccttaaatag ttcagggcct caaaggctcc      180

caagccgccc tgcgcctgtt gctatggcga ctgggcaggc ggccggaagc gcggccttgt      240

tgggggcccc cgttgcccgc ctcccagtag ccgcgcctca ccctaggcca ggaatggttt      300

tagggaagac tgttgccgga tgacaaggct gtcactattg ttctgtacta cctgacatta      360

tgggaccagg ccagccagct tcaacctgtg ttcatctagc acctaggacc caacttgatg      420

ggaggagcga ccccaaagta cttcagaccc agaaccagct gcagtttaat aggaatgttc      480

ctacacattc aagcaacttg gcgatccgat attcttgccc acatgccatt agaattgaaa      540

aactgaagca ctcatacaat gaatcatacc attgtaaaga tgcagattgt agagttggtc      600

ctgacctggg cagttctgtt tcattttccg tcatatccca agagagactt agctatgctg      660

tccacctagc cagaagagat gtgaaacgaa gacaatttga aaaacatata aaagaacatc      720

atctcagaag tcagcctcaa agctctcaga agtgtggaca tactaagtat aaaatacccg      780

accacagggt ggaaaggaag gaatcaaaga gtcaagcagc ctgtcagtgt agccaccagc      840

catccaaagt agaaatctcc agctctggtg ccaaagtata cctttactca tctcatccag      900

gccagtcaga tcttactgtg ccaaattcgc cacccaccca tgatccggga cttcagcctc      960

atcccaggat aggtgaccac aaaaacataa gtgaacagaa aagcctgcta gaagtccagc     1020

gactccagaa agaactgagc agttgtatcc acaaaattga agaggtaact aaaaaagata     1080

gactagaaga agctttggat ccagatgaag aacgtcgaat ccgtatcagg agacaggagc     1140

aagctgctcg ctctgcccga atgctctacg tcctccagca gcaggtaaaa gaaatccagg     1200

aagaattgga taaattgagt ccacataaaa ttaaacacac taagaagtca tgggcaatgt     1260

ctaagctggc ggctgcccat cgaggagcca ttcgggcctt acagatgttt gtcactcagt     1320

ttactgaccg aggggagcat ccacttcctg ctcggtgtaa ggaactgggc agccttattc     1380

gccagctttc actttgttct gtcaagctgg atgcagaccc ttctgttcct gatgtggtta     1440

tagatattct gcaacaaatt gaggctttgg aatctctcct ggaaaagaaa ctgtcaccaa     1500

aaaaggtgaa aaaatgtttc agtgaaattc ggagcagatt tcctatcggt agccaaaagg     1560

ccttggagag atggccaagt acatcaccaa agggtgagag gaggcccctc acagcaaagg     1620

acacattccc acaggaaaca agtcgacctt ctgtagcaaa gcagcttctt gccgataagt     1680

atcagcccga tacggagctt ccggagaccc agaggttgca gagtgagctt gatgtattag     1740

atgcggatat agttctggaa gaaggaccat ttattctaga ccaaagtgca agcttcaaag     1800

acgaggtgtt agccgtggca aaaacaaaag cagggaaaaa gaagcctgtg actgagaatg     1860

tgccgtttag gaagaaagat actctggcgc cagcaagaca gcaaggactc cgcaaagctg     1920

aaagaggtag acaaagccaa cctcacagta aaagcagagt gcagcagaca acagtttcat     1980

ccagattaaa aatgaaccgg cagcctgtga aagaccgcaa ggcaccatgg atacccccaa     2040

accccacatc cccaccagcg tctcctaaat gtgctgcatg gctaaaggtg aaaactagcc     2100

ccagagatgc cacaaaagag cctctccagc aagaagatcc tcaagaggaa agtcacctga     2160

caggtgctgt tgagcatgaa gcagccaggc tcgcttggct tgatgctgaa acttccaaaa     2220

gattgaagga actagaagag ttaaaagcca aggaaattga cagcatgcaa aaacagaggc     2280

ttgattggct tgatgctgaa acttctagaa gaacaaagga actgaatgag ctcaaagctg     2340

aagaaatgta tagactccaa caattgagtg tttctgccac ccacttagca gacaaggtag     2400

aggaggcagt tctggatcgt ttgaagcctc tcttggtcaa ggcccagaga gtcaattcta     2460

ctacagaagc aaatattcat ttgaaagatg gctcgtcagt aaacacagcg aaagcccagc     2520

ctgcacagga ggttgcagct gttgattttg aatccaacaa cattcgtcag cttgatgatt     2580

ttttggaaga ttgtgccagt gagctctggg ctgtgactca tgctaagatc ttggggtctg     2640

aaaccttagc caccgttgag gacagcaagg atagcccaga tctggagatc atgatgcgcc     2700

gaatggaaga gatggaaaaa taccaggagt ctgttcgtca aagatataat aaaatcgcat     2760

atgctgatcc tcgactttgg atgcaggaag aaaacaatga ccaaaaaatc tcagcaataa     2820

gtgaaaagcc tctatctcct catccaatca gaatcacgaa gacagtggat cgcaaggatc     2880

cagccgtgaa catcatgtta gaaaggccct gtaatggcaa ttccctggat gaaagtgtgg     2940

gaacagagga aggatcagag aaaagagagg cccctcttct ctccctagcc gaagattctc     3000

aacagaaaga aggccgagct cccctctttg tcccaccggg tatgcagcac agcatcggtg     3060

actactgtag tcgttttgag cagtaccttc ggatcatatc tcatgaggct gtaggctcct     3120

tcaacccgtg gctgatagct gaaagctttt cagaagagct ggtagatgaa gctctgggtg     3180

ctgtggctgc tgaacttcag gatatgtgcg aagattatgc agaagctgtg ttcacctcag     3240

aattcttaga ggctgctaca taaaggctct ctgaggcgag gccatttgtg tcacactgga     3300

gaagggatgg caccaccctt tgttttggcc cacaggaaat tttcatcctc agctgtccat     3360

ccaggcccag aaggtgctgc ccactgaaag gaaggcagtg ccggggaggt catcctcact     3420

ttgcattttc ttttgtcatg gcaatggttc tggaaatgta tgatgcaatg tatcacactt     3480

atcagtgccc aggcaacaca acttgattat ggcaatattt tcagaatgtg tacttttcct     3540

attgaaatac catgttcatt cctctggctc agtttggtga tgaaaatgtt ttgaaagata     3600

atcgatacgt atatttcaca caaggattca ggttgctgtt gaacccttgc tggcattgat     3660

accaacacaa gtgcggctac tagctggtcc catcacgggg cccctgtttt gcatctttgg     3720

cgatttcctg tcaggacctc tggccctact aggctgtaga ctcagggaga gcacagtctg     3780

gctgtgctgc caaacctctc ctctgctgca gtttattcca aacaggagcc ccctggctgt     3840

cagtgcacaa taatagacac acatttcttc aacgttccat tcctaggtga ttttcacatt     3900

tttagttcct cagcatattt tattgctgtg tgttgacaca atctggtata aaaaactttc     3960

tctggattca gaggaagttt gaggaatcag gagaggacca ggccttctcc tgtgcctggg     4020

tgaaggtaca gacctcgctg tgtctccgat gaggtcagaa gtgtctctat ttcataccac     4080

aaaggaaccc aagtgggagt agggaacaga tggatggcgc gaagacctct gtgtctcccc     4140

agagaaagga agaaacttaa gaaccatcat agcctggtcc tccaacatct tacagatcat     4200

gttttccaag agaaaagcct gtgttttcag aaactctgaa ttcagaaaaa gaaacggaat     4260

gtgcgtaaga atcaggccac tgcctggaaa gactttctct caattcgtag cctgaggctc     4320

agtgaaggaa acatgcagaa agaatgcctg agacgccccc agggaataag ggaactcttt     4380

ataacctgtc cagtgccgtc atctgggatt tttctctgaa gtacaagaat ttcaggtgat     4440

ttaagctgct tgatcacact tatttgtgca aaattgattt tcatttaatg ttaatgtttt     4500

cctgcttaat tttatataac ttcagaatgt aaagagcttc aaggtaaatt acagggtgtt     4560

taacctgggg agttaaatgt gtacacttga attaatagga gcaccggttg ttgctagtat     4620

aaagtaattt gtgtggcagt ttgtactgtg ctgagttttt aaaataaacc caatatttta     4680

aagt                                                                  4684


<210> 1530
<211> 8006
<212> DNA
<213> Homo sapiens

<400> 1530
ctgcggcggc gcgctccgag cctgcgtcta gggcgccccc gggtcagagc tgtcgccgtg       60

gccgccgctg caagaaccat gtaccgcagc agcgctcgct cctccgtctc ttcccaccgg      120

cctaaagacg acggcggggg cggcccgcgc agcggccgca gctctggctc ctcctcaggc      180

ccggctcgcc gcagctcacc gccgcctccg ccctccggct cctcgtcgcg gaccccggct      240

cgccgacccc gctcgccctc agggcaccgc ggccgccggg cctcgccgtc cccgccacgg      300

ggtcgtcgcg tctccccgtc cccgcctcgg gcccgtcgcg gctccccgtc gccaccgcgg      360

ggccgacgac tcttcccgcc gggcccggcc ggcttcagag gcagcagccg gggggagtcc      420

cgcgccgact atgcccggga cggccgcgga gaccatccag gcgacagcgg cagccggaga      480

cgctctcctg gtctgtgttc tgactctttg gaaaagagct taaggatcac tgttggcaat      540

gaccacttct gtgttagcac accagaacgg cgacggctta gtgatcggct ggggtcacca      600

gtggataatc tggaagacat ggacagggat gacctgactg atgattctgt cttcactcga      660

agctcccagt gctctcgggg tcttgagcga tatatttccc aggaggaagg gcctctcagt      720

cccttcttgg gacaacttga tgaggactac cgaacaaaag aaactttcct gcatcgatct      780

gattatagtc cccatatcag ttgtcatgat gagctgttgc ggggaacaga acggaatcga      840

gaaaaactca aaggctactc catacgatct gaagaaagga gccgggaggc caaaagaccc      900

cgttatgatg acacagtgaa gataaacagc atgggagggg atcacccaag ttttacatca      960

ggaactcgca actatcgaca gcgtagaaga agcccaagtc ctaggtttct cgaccctgag     1020

tttcgagaac tggatcttgc cagacgaaag cgagaggaag aggaggagcg aagtaggagc     1080

ttgagtcagg agctggttgg agttgatggt ggtggtactg gctgttccat ccctggattg     1140

tcaggtgtcc taacagcatc ggagccagga tattctttgc atcggcctga ggaagtatct     1200

gtgatgccca agaaatccat tttgaagaag cggattgagg tggacataat ggagccctcc     1260

atgcagcttg agagtttttc cagcagtacc agctccagcc aggatcaccc tctctactct     1320

gggcacccat cccttccact aagtggtgct attgctgctt ttgcctcaga gattgaaaac     1380

aaggggacta tggtagagac tgccttgaag gaacctcagg gcaacctcta ccaatggggt     1440

ccccttcctg ggattcccaa agacaacagt cctctcagag aaaaatttgg aagttttcta     1500

tgccacaagg ataatttgga tttgaaggct gagggacctg agcgacacac agacttcctg     1560

ctgccccatg agagagctag ccaggatggc agtggttttt cccgcattct gagcatgttg     1620

gctgattcta ccagtacaca ggaaaaaagg cgacgtagct ttcccgacat tgaagatgag     1680

gagaaatttc tctatgggga tgaagaagag gatttaaagg cagaatccgt accaaagccc     1740

cttgggagct ctgagagtga agttatgagg cagaaggcaa gctccctgcc gtcttcagct     1800

ccagctgtaa agctagaatc actagaagag accaatccag aatatgcgaa gatccatgac     1860

ttgctcaaga caatagggct ggatattgga gtagcagaga ttagtcaatt ggctgcacgc     1920

acccaggaac gacttcatgg caagaagcca tcattacgct cctcagctga ccgccgttcc     1980

tcagttgacc gatacttttc agctgaccac tgttcctcag ttgaccaccg cttctcagct     2040

gaccgctgtt cctcagttga ccactgcttc tcagctgatc gacgttcctc agatccccac     2100

agactagaga gcagggaggc acatcatagc aatacccact ctccagaggt gtcccatcca     2160

cacccacctt ctcctgtgga tccttacctg ctcacaaaaa acagccctcc attcctaaag     2220

tctgaccatc cagtgggtca tatttcagga ccagaggtgg ttggtagtgg gtttcagtca     2280

tctgttgcag tcaggtgcat gttgccatca gccccatctg ccccaattag acttccacac     2340

actgctgctt tatctcagtt tcacatgcca agggcctctc agtttgctgc agctcggata     2400

cctccgaact accagggacc tgccattccc cctgcctctt ttgatgccta taggcactac     2460

atggcatatg cagcctccag atggcccatg tatcccacct ctcaaccgtc aaaccaccct     2520

gtacctgaac cacacaggat aatgccaata accaaacaag ctactcgtag ccgtcccaat     2580

cttcgtgtga tccccactgt gactcctgat aagcctaagc agaaagagtc tctgcgaggc     2640

tcaattcctg cggcccaagt gcctgtccag gtgtccattc catcactcat aagatataat     2700

ccagagaaga tctctgatga gaagaaccgt gcttcccaga agcaaaaggt tattgaagag     2760

agggaaaaac taaagaatga ccgggaagcc cgccagaaga agatgtacta tcttaggacc     2820

gagttagagc ggcttcataa acaacaagga gaaatgctgc gcaagaaacg aagggagaag     2880

gatggccaca aagatcctct cttggtggag gtgagtcggc ttcaggataa cattatgaag     2940

gacattgcag agctacggca agaggcagaa gaggcagaaa agaagcaatc tgaactggac     3000

aaagtggctc agatcttggg aattaacatc ttcgataaat cccagaagtc tttaagtgac     3060

agtagagagc ctacagagaa gcctgggaaa gcagaaaaat ctaagagccc agaaaaagtg     3120

tcatcgttct caaactcctc ctccaacaag gaatcaaaag taaacaatga gaagtttcgt     3180

actaagagcc ccaagcctgc cgaaagcccc cagtcagcca ctaagcagtt ggatcagccc     3240

actgctgctt atgagtatta tgatgctggc aatcactggt gcaaagactg caacaccatc     3300

tgtgggacca tgtttgattt cttcactcat atgcacaata agaagcacac acagacactg     3360

gatccctaca acagaccttg ggcttcaaag acccagagtg aggccaagca agatgccata     3420

aagcgcactg acaagataac tgttcctgca aaaggctctg agtttctggt tcccatcagt     3480

ggattttatt gccagctctg tgaggaattt ttgggggatc caatttctgg ggagcaacat     3540

gtgaagggtc accaacacaa tgagaaatac aagaaatatg tggatgaaaa cccattatat     3600

gaggagcggc ggaatctgga ccgccaagct ggcttggctg tggtcctaga gacagaacgg     3660

cgacggcaga gtgagctaaa gcgcaaactt agtgagaaac caaaggagga gaagaaagaa     3720

aaaaaggcaa aggctgtgaa agaagtaaag gaggatgaca aggtctctga gaaattagaa     3780

gaccaactct ctgagggtag gaactcccct gaaaaagctg aaaataaaag gaacactggc     3840

atcaaactcc agttaaaaga agaggtaaag aaggaatcac caacatcatc ttcttttggg     3900

aaattcagct ggaagaagcc agaaaaagaa gaggagaaaa gttcattggt gaccccaagt     3960

atctctaaag aagagattct agaaagtagt aaggacaaag aggatggcaa aactgaagct     4020

gggaaggcaa agcctatcaa aatcaagctc tctgggaaaa ctgttgttgc acataccagc     4080

ccttggatgc ctgttgtgac aacttccaca cagactaaga tccgacccaa cctgcctatt     4140

ccatccacag tactccgcaa gtcatgttca gccacaatga gcaagccagc tcctcttaac     4200

acctttctgt ctattaagtc ctctggaacc actgctaaac ctctgccagt ggttaaagag     4260

tcttcagctg atctcctctt acctccagac atcatctcca aagcatttgg aggggaagag     4320

gtgattctaa aagggtctcc agaggaaaaa gtggtgttgg ctgaaaagag tgagccatct     4380

catttacctg aacaaatact accacctcct ccaccacccc cacctccacc acctccacca     4440

ccccccgtta tacctcatcc agctgccccg tctgctgctc aagcaaatgc tatcttggct     4500

ccagtaaaat caaacccagt tgtatctcag actctcagcc ctggcttcgt gggtcctaac     4560

attttgaacc cagtgttgcc tgtagccatc atggcctcag cacagccagc tgccattcct     4620

tctgatgaga cagctcctgg ggtgagtgag agtgaccgag accagaccct gttctctgtg     4680

ttagtacgtc ctccaccacc cctctcaagt gtgttcagtg aacaagccaa aaaattagag     4740

aagcgaaatt catgcttagc cacagccaat gctaaggacc tgtatgacat attctatagt     4800

agtggtggaa agggggcccc tgagactaag ggggcccctg agactaagct aagtggtggt     4860

ccattggcca atggggaaaa tagcaacctc tctagaacca aaagttcaga cacctcttct     4920

acttctcctt tgaacagcag tgcatcccaa gaggagttgc atcaagatga gggtttggtc     4980

gctgctccta tagttagcaa ctctgaaaag cccattgcaa aaactctggt ggccctaggg     5040

aaatggtcag ttgtagaaca tgtaggccca aaaagcacag gcagcaccta tggcttccta     5100

cagcctctga caaggttgtg ccaaagcagg ccttatgaaa caattacccc aaagacagac     5160

actttggcca tatggacctc tagttccttc cagagtgaca ctagtaggga tatatctcca     5220

gagaagagtg agcttgacct gggagagcca ggaccacctg gtgtagaacc acctcctcaa     5280

ctgttagata tacagtgcaa agaatctcag aagttggtag aaatccacct cagagaatct     5340

gttaaccagg ataaggaaag ccaagagctc cgtaaatctg aggattgtag agaaagtgag     5400

atagagacaa acactgaact aaaagaaagg gtaaaggagc tgtctgaggg gatagttgat     5460

gagggagtaa gtaccagcat tggaccccac agcatagatg attctaattt gaaccatgga     5520

aacagataca tgtgggaggg agaagtaaaa cagcccaact tgctaatgat tgacaaagag     5580

gctgaacagt ccaataaatt gatgacagga agtgaaactc caagtaaagt agtgatcaaa     5640

ttgagtccac aggcttgctc tttcacaaag gcaaaattag actcattttt atcagaagct     5700

aggtctttac tcaacccaca agatacacct gtgaaaattt ctgccccaga gttgctgctt     5760

cattccccag ccagatcagc tatgtgttta acaggtagtc cacaagagca aggagtttca     5820

gttgttagtg aggaggggct agagaattca gctccagaat cagcttctag aacttctagg     5880

tacagaagtc tcaaactcaa gagagaaaga tcaaaagact ttcaagttaa aaagatctat     5940

gagttggctg tttgggatga aaacaagaag aggccagaga cctgggagag cccagagaaa     6000

ccaaaaacag aagcactgga gctacaagat gtccatccag agttaacagt gacaatagaa     6060

agcaaggccc tagaagactt tgaagctaca gacttaaagg tagaggagct tactgccctg     6120

gggaatctgg gggatatgcc tgttgatttc tgcactactc gggtaagccc agcacataga     6180

tccccaactg tcttgtgtca gaaagtgtgt gaagaaaatt ctgtatcacc tatagggtgt     6240

aattcctccg atcccgctga cttcgaacca atcccatctt tttctgggtt tccgttagat     6300

tctcccaaaa ccttggtgct tgactttgag acagagggtg aacgaaactc acctaatccc     6360

aggagtgtta ggatcccttc tcctaacatt ttgaaaactg gacttacaga aaatgttgac     6420

cgtggcttgg ggggcctaga gggaacacac caggcccttg acctgttagc aggaggaatg     6480

atgcctgagg aagtaaaaga atcttcccaa ttagacaaac aagagtcact cggattggaa     6540

ttaaaaacaa ttaattctgc aggccttggg ccatctcctt gccttccaga ccttgttgac     6600

tttgtcacac ggacctctgg agttcaaaaa gataaactgt gttctccact ctctgagcca     6660

ggtgaccctt ctaaatgtag ttccctggag ttggggccat tacagctaga aatatcgaat     6720

gcatccacca cagaggtggc aattctgcaa gtagatgatg acagtggcga ccctctgaat     6780

ttggttaaag ctccagtgtc aaggtcccct ccaagggagc aggtaattga agacaatatg     6840

gtccctcagg gaatgcctga acaggaaact acagttggtg ccatccagga ccacacagaa     6900

tccagtgttc acaactaaga ataaatacct agagctactt gtgagtgaat cattggcttc     6960

tagaaatcag atgcccagat gatccaagac tagtttgtta tctcatctgg aacctacacc     7020

aagagatgca gtcagcatct taaagtaaat gttcatggaa gctaaaaaat ttacctcctt     7080

tccttttccc tttcccctta aaacaccaga caaatcgata acaacttata tatatatata     7140

tatatctgta aaaatgtatt ttgttaattt ttttggccaa tttattttct cccactttgt     7200

cattaaaatc acatgtctaa ctggctcacc acatagtgtg ctttgattgt attttggctt     7260

tgactctgcc atttctgaaa tgtgggggag gatggaggca gctgacctct ccagttgctg     7320

tgttgtattc ctacccaatt tcctgggcag ttgatgcatc tctgggaaaa acaccagaaa     7380

gcttgctgaa atggaaaact tggaagaatt gttcatctct taggcttcca tttggatggg     7440

cctgccttaa cattgtttga aatgcagcgt gagtagctct tttgtttact gtttacaccc     7500

cttattggca tgtcaactcc tgtacttccc ttactctgtt gcctttcttg agatgcattg     7560

tcctgctaac ccacaaacct gtttggaaat aaacatggaa gaatatctgg caggcttact     7620

tttagaagac gacaaatcgg taaggcttat tcatggttca ttgccaggag cagatatgct     7680

tttgagatca cttttatttt tgaaatggcc tttgttcatt gtattgtgat ccaataacac     7740

tttgtattaa attgtttagc agccatttgt gttgtgaagg ggtagaagat ctctgaaact     7800

tgtcttgaga ttgaactcat tccctgttcc acaaacccat atgtatcctt tcctctacct     7860

cctcctttcc caattaattt caaccatagt acgatgtttg gggttgtata ttttgttaaa     7920

aagattaaag aatttatgag ttggcttgga caagtttaac tttattttta atgtgttaat     7980

tacttggaat aaatgcatta atctca                                          8006


<210> 1531
<211> 2755
<212> DNA
<213> Homo sapiens

<400> 1531
acaatcactt ccgccgccgc agtcgccgcc cgccccgctg ctgtctggcg ggggaggagc       60

tcgggaccgg gagcagcggc tctggcggtc gtggcggtcg gagatccgag agctctgctt      120

ctctgaaaag cgtgtggctt tctggacttg gtctacacct gacagtcact ggaatgctac      180

tccaggcctt agaagaaagt gaaactaatt ttaaaggccc cttattcttt ctgttacctg      240

cctgctgaag tgaaaataaa tctccctgct cctttattct aaactgattt tactttccca      300

tctcaaaaac gtgtgcaggg agcaggagcc ctcctacccg agccccagct gtattggaaa      360

ccctcctaag tcagagtgat gggtcaggaa tctagcaagc ctgtatggcc caatccaaca      420

ggagggtatc agtccaatac aggtaggagg tatggaagaa ggcatgctta tgtcagtttc      480

aggccaccca cgagccagcg ggaaaggatt gccagccaga gaaagacgaa ctccgaagtc      540

ccaatgcaca gatcagcccc cagtcaaacc accaagagga gccgatcgcc attttccact      600

actcgtcgta gttgggacga cagcgagagt tcgggaacca acctgaatat tgataatgag      660

gactattcca ggtatccgcc aagagagtac agagcttcgg gtagcagaag aggaatggcc      720

tatggacata ttgactctta tggggcagat gatagtgagg aggagggggc tgggcctgtt      780

gagcgaccgc cagtgagagg gaaaactggc aagtttaaag atgataagct gtatgaccca      840

gagaaagggg caaggtcttt ggctgggcca cctccacatt tctctagttt tagccgtgat      900

gtgagagagg agcgagacaa gttagaccca gtccctgcag caagatgctc agctagcaga      960

gctgacttcc tgccacaaag tagtgtggcc tcacagtcgt cttctgaagg caagctggct     1020

acaaaaggtg acagctcgga gagggagaga agggagcaaa atttacctgc acgtcccagc     1080

agggctcctg tgagtatttg tggtggtggg gaaaacacct caaagagtgc agaggaacct     1140

gtggtcaggc ccaaaatcag aaacctggca agtccaaact gcgtgaaacc aaaaattttt     1200

tttgatactg atgatgatga cgatatgcca cacagtactt ccaggtggag ggataccgcc     1260

aatgacaatg agggccactc ggatggcctg gcaagaagag ggagaggcga gagttcaagt     1320

ggctatcccg agccaaagta ccctgaagac aaacgggaag cgaggagtga ccaagtgaaa     1380

ccagaaaagg tgccgagacg acgacgcacc atggccgacc ctgacttctg gacgcacagt     1440

gatgattact acaaatactg cgacgaagac tctgacagtg acaaagagtg gattgctgct     1500

ctgcgtcgga aatatcgaag ccgagagcaa accctgtcct ccagtggcga aagctgggag     1560

actctgccgg ggaaagaaga gcgggaacct ccacaggcta aggtgagtgc cagcactggc     1620

accagccctg gccccggtgc tagtgccagt gccggggctg gcgccggggc cagtgctggc     1680

agcaatggca gcaattacct tgaagaagtt cgagaaccat ctcttcagga agagcaggca     1740

tccctggaag aaggagaaat tccttggctc cagtaccatg agaatgacag tagcagtgag     1800

ggggataatg attctggtca cgagttgatg caacctgggg tattcatgct ggatggaaac     1860

aacaaccttg aagatgactc cagtgtgagc gaagacctag aagtggattg gagcctcttt     1920

gatggatttg cagatgggtt aggagtggct gaagccattt cctatgtgga ccctcagttc     1980

ctcacctaca tggcacttga agaacgcctg gcccaggcaa tggaaactgc ccttgcgcac     2040

ttggagtctc tcgcagtgga tgtagaggtg gccaatccac cagcaagcaa ggagagcatt     2100

gacgctcttc ccgagatcct ggtcactgaa gatcatggcg cagttggtca ggagatgtgc     2160

tgccccatct gctgtagcga atatgtgaag ggggaggtgg caactgagct gccgtgccac     2220

cactatttcc acaagccgtg tgtgtccatc tggcttcaga agtcaggcac ctgccccgtg     2280

tgccgctgca tgttccctcc cccactctaa agaccaaggc cgtttactcc tggtctgatt     2340

attttcccca tctgaaatcc acaatactgc aggagccctc ttgaaattaa caatggaaat     2400

aaaaccaatc agtcagttag cctaaaccta ttgattcctc gtgattattt ccaatgtgaa     2460

aacagttgtg tatgattgca ttaaaaatca tatcatcttt tagaggttag aaaagggaaa     2520

actaaacttt ctaaatgcta cttgagattg cagtaagaag atacgttttc taacctgaaa     2580

gttaaatcgc atttgttttc ttcagtagaa tgggaatgtg ttgctgttac ttgtaatgtc     2640

aagtttatct gttaaatatg tccaaaaggc aaaatcattt ttgttgcatg ttatgggtcg     2700

atgttcctgt aattgcagtg ccgtaaaagc ttattaaagt tgttcttttg gtttt          2755


<210> 1532
<211> 3438
<212> DNA
<213> Homo sapiens

<400> 1532
actcggtgca gaccgaacca tcgcggccgc cgccagccgg gcccttcgcg gccgcgcgtc       60

ctgggcccgt tccgccagcc ccgtctgctc tctacccgcg gccccgcggc ggcgaccgtg      120

aacactcggc ggcccctaca gcccgctctc ggcccttcgt ccctcgcggg ccccgactct      180

ccctccttgc agtcccccgg agcctggctc ccggctcggg ccgcaccgcc agggactggg      240

gtgagcggcc cagaaatctc caaattggac atccagagca gcattcttgt tctgtctacg      300

tcttgaatta gaaactatca agctctgtaa gtcctgaaaa ggaaataaaa ggtgcgtccc      360

tacccaagag gagaggtggc cagtaaatgt cagctgaggc accgaaggct gcgatgcacc      420

agcccggtgc cctgtgagga cggccacatc aatagtggta acactcacaa tttcctgctg      480

cagagagcat tttaagaaag gacagcattc ctgtgacctc tgcctaccat ccataaaata      540

ctcattcccc tctcagctct gcctgcagtt gaacacaaag acctggagga gactcccacc      600

tccttcaggg agaagaaagg aggcagcgaa gcagattaaa ggaacttgtg gcttgtggcc      660

tttttgtgca agggccgcct ggaaggggag aaaagtgtat gaaagccacc gtggcggtta      720

atgagctgtg agatgaggcg ctgctgcggc cgctgctgct gacactcgct cccaggctgc      780

acccgccgcc cttggcgctt catgtacatg tgtctattca ggccttgcgg aggcgcccag      840

aagagcatcc aacacggctg ccggggaaag accgcccacc atgcccacgg agaccctaca      900

gacaggtagc atggtgaagc cggtcagccc cgcgggcacc ttcacctctg ctgtgcccct      960

gcgcatcctg aacaaggggc cagactactt ccgcaggcag gccgagccca accccaagag     1020

gctcagcgcc gtggagaggc tggaggccga caaggccaag tacgtcaaga gccaggaggt     1080

gatcaacgcc aagcaggagc ccgtgaagcc cgccgtgctg gccaagcccc cggtgtgccc     1140

ggctgccaag cgcgcactgg gcagccccac gctcaaagtg ttcggcaacc acgccaagac     1200

cgagagcggc gtgcagaggg agaacctgaa gctggagatc ctgaagaaca tcatcaatag     1260

ctccgagggc tctagctcgg gctcggggca caagcacagc tcccgcaact ggccgcccca     1320

ccggtcggaa gccactgacc tgcaccgtca ctccttcgcg gagtccctga aggtctaccc     1380

cacgcagggc cgcaggagcc cgcaggaggg cggctcccac gtgggcagga gactgctgga     1440

gcagtcagcc gagtccttcc tccacgtgtc ccacagctct tcggacatcc gcaaggtgac     1500

cagcgtgaag cccctcaagg ccatcccctg cagtagctct gcccctcccc tgcctcccaa     1560

gcccaaaatc gcagccatcg cctccatgaa gtcccccgag gccgaccctg tggaaccagc     1620

ttgtggagtc agccgaagac cctccctcca gcggtctaag tcagacttga gtgacagata     1680

tttccgagtg gacgcggacg tggagaggtt cttcaactac tgtggactgg acccggaaga     1740

gctggaaaac ctgggaatgg aaaactttgc aagggctaat tctgacataa tatccctcaa     1800

cttccgcagc gcaagcatga tcagctcaga ctgtgaacag tctcaggaca gtaacagtga     1860

ccttagaaat gatgacagtg ccaatgaccg cgtgccgtat ggcatttctg ccatcgaaag     1920

aaatgctaga atcatcaagt ggttatatag catcaaacaa gctagagagt cacagaaggt     1980

ctcccatgtg taagacagtg cgtggaaagg agggagcgtg ggtctctgtg cttacgcagt     2040

tgtgaaggtt gtgaggtctc cttgaagtgt tgtgagcttc tccactcttt gtgttgcttg     2100

ttgtgcaatg ttttcaagtt gcatgcttgt caacatgggg actgacctgg cttccacgtc     2160

accatcgcta cagagcctgg ctgaacacgc gtcatctgcc aaaagtttca ggccagaatc     2220

taattagggc tttgctcgta agcaaaactg tttacatgaa aatggtatac aacttcttcg     2280

atatttatgt ggttcttgtg tttttatatc ccgcgctatt gtgtcttaat taaaagtttt     2340

atcaactggc ttttaagttg agagcagaat ctttttgaaa taaaaagcca ctttgcctac     2400

atgtgagact attccagtgg gacagtaaat gggatctgct accaaacaga taatgactga     2460

ccgaacatag aaccaggctg ggttttctgt ggaataaagt ggtgagcctg acgttaatcg     2520

tttacatgtt gaaattctct tgccacttag tgaagcagtc attggggtaa caatgctacg     2580

ttttgtgtcc gattcagtgt gtaaacgttg gtggttctat gtaatactga ccccaaggaa     2640

agacgatcag atacaaagaa agatggttaa atctaggagg ttgggtgttt gggggttttg     2700

ttgatgttgt tctgattggg ataattcaga aattcctaat attatctttc gacagaatga     2760

ccaccctaaa acaaatactg aatgccttta aaaaaaaaaa aagttgtggt tttttgtttt     2820

tttttttttt ttttttggtc gagaactact aatttcatgc tatttctttc tctctccctt     2880

tgttgttatt tgatttgggg gaagggagtg aggcttgtgc agatttgagc tatctgaaga     2940

catgaacaga agtcaaatac cagccatatc agtagagcct tccattcaaa agtgaacaca     3000

cttggtagct gaaccatatc tgagcagcgt gattctgttg tcttgcatat gttattctct     3060

caggctgtgg atctttgtta cagctctagg aaactgtaga aatacaatgc tatgtagctt     3120

ttccacccca tggtctctag tgctgcctat caacttgtcc ccttttttcc caataacctg     3180

tcttccaggt ggtacagtta gctgtcactc agctgacacc atgatgtggc agcagagagg     3240

gaaacctaca agtggtttgc ctcattgcct ttgccacatc tgaagttctc agcagcacta     3300

ccttagactt catgagctaa taggaaactt tttatggtgt aaatgctgta agactttgta     3360

catacttcag ttgttatgaa atctttaaag aaaaaaagaa aaagttacgc taataaattg     3420

ctgtggtgca ggcactaa                                                   3438


<210> 1533
<211> 11435
<212> DNA
<213> Homo sapiens

<400> 1533
gccgcgcgcg ggggccgtca ttcggtggcg ggtcccggcc gcggggctgg cgggctgagg       60

ggagaaaaga tggcggcggc ggcggcagct ggtgcggcct ccgggctgcc gggtccagtg      120

gcacaaggat taaaggaagc gttagtggat acgctcaccg ggatcctatc cccagtacag      180

gaggtgcggg cggctgctga agaacagatt aaggtgctgg aggtgacgga ggaatttggt      240

gttcacttgg cagaactgac tgtagatccc cagggggcac tggcaatccg tcagctggca      300

tcagtcatct tgaaacaata tgtggagact cactggtgtg cccaatcaga gaaatttagg      360

cctcctgaaa ctacagaaag ggcaaaaatt gttatccggg agctattgcc taatgggttg      420

agagaatcga taagcaaagt gcgctccagt gtggcctatg cagtgtcagc cattgcccac      480

tgggactggc ctgaagcttg gccccaactc ttcaacctgc tcatggagat gttggtgagc      540

ggagacttaa atgccgtcca tggagccatg cgtgtgctga cagaattcac tcgtgaagta      600

acagacacac agatgccact tgttgctcct gtcattctcc cagagatgta taagatcttc      660

accatggctg aggtgtatgg tattcgaacc cgttcccgag ccgtggagat ttttaccact      720

tgtgcccata tgatctgtaa catggaggag ctggaaaagg gtgcagccaa agtcctgatc      780

tttcccgtgg tacagcagtt cacagaggcc tttgttcagg ccctccagat accagatggc      840

cccacatctg acagtgggtt taagatggag gtcctaaagg cagtgacagc cctagtgaaa      900

aacttcccaa agcacatggt gtcctccatg cagcagattc tgcctattgt ttggaacacc      960

ctaaccgaga gtgcagcttt ttatgtgagg acagaagtaa attacacaga agaagtagaa     1020

gatcctgtgg attctgatgg tgaagtcctg ggctttgaaa atctcgtctt tagcattttt     1080

gaatttgtcc atgctctact agaaaatagc aaattcaaaa gcactgttaa gaaagccttg     1140

cctgaattga tttattatat tatcctgtac atgcaaatca ctgaggagca gattaaagta     1200

tggacagcca acccccaaca atttgtagaa gatgaagatg atgatacatt ctcctatact     1260

gttagaatag cagctcaaga cttgttgctg gctgtggcca cagatttcca gaatgaaagt     1320

gcagcagccc tggctgctgc agccactcga catttacaag aagctgagca aaccaaaaac     1380

agtggcactg agcactggtg gaagatccat gaggcatgca tgcttgccct aggctcagtg     1440

aaggccatca tcactgacag tgtgaaaaat ggcaggattc attttgacat gcatgggttc     1500

ctgaccaatg tcatccttgc agacctcaac ctctcagtgt ctcctttcct cttgggccgg     1560

gcactttggg ctgccagtcg gttcactgtt gctatgtccc ctgaactgat ccagcagttc     1620

ctacaggcaa cagttagtgg tcttcacgag acacagcccc catcagttcg aatttctgca     1680

gtgagagcca tctggggtta ttgtgaccaa ctgaaagtct cagagagtac ccacgtgctc     1740

cagcccttcc tccccagcat ccttgatggc ttaattcacc tagcagccca gttcagctca     1800

gaggtcctca acctggtgat ggagaccctg tgcatcgttt gtacagtaga ccccgaattc     1860

acagcaagca tggaaagcaa aatctgcccc ttcaccatcg ccattttcct aaagtacagt     1920

aatgatcccg tcgtcgcctc actggctcag gacatcttca aggagctgtc ccagattgaa     1980

gcctgtcagg gcccaatgca aatgaggctg attcccactc tggtcagcat aatgcaggcc     2040

ccagcagaca agattcctgc agggctttgt gcgacagcca ttgatatcct gacaacagta     2100

gtacgaaata caaagcctcc cctttcccag cttctcatct gccaagcttt ccctgctgtg     2160

gcacagtgta cccttcacac agatgacaat gccaccatgc agaatggcgg agagtgcttg     2220

cgggcctatg tgtcagtgac cctggaacaa gtagcccagt ggcatgatga gcagggccac     2280

aatggactgt ggtatgtgat gcaagtggtg agccagctcc tggacccccg cacctcagag     2340

ttcactgcgg cctttgtggg ccgccttgtt tccaccctca tctccaaggc agggcgggaa     2400

ctcggggaga atctagacca gattcttcgt gccatcctca gtaagatgca gcaggcagag     2460

acgctcagtg tcatgcagtc cctgatcatg gtgttcgctc atctggtgca cactcagcta     2520

gaacctctct tggagttcct gtgtagcctc ccaggaccta ctggcaaacc tgctctagag     2580

tttgtgatgg ctgagtggac aagccgacag cacctgttct atggacagta tgaaggcaaa     2640

gtcagctctg tggcactctg taagctgctc cagcatggca tcaatgcaga tgacaaacgg     2700

ctacaggata tccgtgtgaa gggagaggag atctacagca tggatgaggg catccgcacc     2760

cgctctaagt cagccaaaaa cccagaacgc tggacaaaca ttcctttgct ggtcaagatc     2820

ctaaagctga tcatcaacga gctctccaac gtcatggagg ctaatgccgc tcgccaggcc     2880

actcctgcag agtggagtca agatgactcc aatgatatgt gggaggacca ggaggaggaa     2940

gaggaggagg aggaggatgg tttagctggc caacttttat ctgacattct tgctacaagt     3000

aaatatgagg aggattacta cgaggatgat gaggaagatg accctgatgc cctgaaggat     3060

cctctctatc agattgatct gcaggcatat ctcacagatt tcctctgcca gtttgctcag     3120

cagccctgct acataatgtt ttcaggccac cttaatgaca atgagaggcg agttctacag     3180

accatcggca tctaaaaagg ggagcctttc tacatttgct ccttctgggc cagccgcaaa     3240

ccattttgca gccctcactg gccttgagat gcactttctt ctcaacctaa agtggcatct     3300

tgacccttgg cccttggcct cggcagtgac actgatgaca attcagacca ggctcaccgg     3360

tgccgtcact taggaatgct ggaacaaagg acatttctca aagttcccct gaagacatgc     3420

catctctaga accttttttc tccccgactc tacccccacc tctgttccta gagccctctg     3480

ctggcgagtc cagaaacatt attgcccaga aggattatgt gtttatggat tattttgccc     3540

cgcctcagga gcgcaggaag tcactaccat ttatattcta aaacagacct atctatgttc     3600

ataggacttc tgatgtgttc agataggaat cctcatgaga gatcattatg ctttgtgccc     3660

tggaccactg ctgctctggg ttctcaggag gaacaggcaa gagcagcttc attctaagcc     3720

tttccagtga cctcagcctt gcttctcttc tacaacacta aggctcctct gtcagaggag     3780

gtcgtcttgt ttttgcttca ttgcatgaca taacccttcc cctcaagctg ttcctatata     3840

tacatgcaca cacaaaataa gccagacaga tggcaatttg atcttccttt tttagaaaaa     3900

aaaaaaaaaa tggggaaaag ggattttttt taaatccacc tgacccaact atatttaata     3960

tgcctctccc acacattacc acagagtctg atattcaaag gttatcccct ttccctcagg     4020

aagcctctaa agtgcttaag ttgtagccct caaatttgca acatgtattt ttctaggaca     4080

gtaaagtaat ctttacaaat gaatttagtt gcatggtata aggtgtctca gcacctgttt     4140

gccttctatt ccctttagaa ggtaagtaaa agtaatgggg gaaaggatta ggtggagcct     4200

gtctaaacat tctagtgtgt cttggcaaac atagcctgaa atgattctta aagaactggc     4260

attgtttaat caaatatttt taagggagat tccttaattg ggaagtttag tctgtttggg     4320

gttcaaagag taaatgagga ttagaaaatc atggagagag gctgggcgcg gtggctaacg     4380

cctgtaatcc tagcactttg ggaggctgag atgggcggat cacttgagat caggagtttg     4440

aggctagcct ggccaacaca gtgaaacctg catttctact aaaaatacaa aaattagctg     4500

ggcatggtgg tgcatgcctg taatcccagt taacttgaga tgctgaggca ggagaatcgc     4560

ttgaacttgg gaagcagagg ttgcagtgaa ccgatatcac accgttgcat tccaaggcaa     4620

gactcaatca cacacacaca cacacacaca cacaaatcat ggggagaaag atgaaacctg     4680

tgttcccctt tttttggtag tgcccacatc tggtgcccca tttttaataa ccacaggata     4740

tttctttaga ttgatattct cacaaagaag aaatagaata taggctgggc gtggtgtgtc     4800

acacctgtaa tcccagcact tacggaggcc gaagccagcg gatcaccaga ggtcaggagt     4860

tcgagaccag cctgaccaac atgatgaaac cctgtctcta ctaaaaatac aaaaattagc     4920

caggcatggt ggcatgcact tgtaatccca gctactcggg aggctgagac aggagaatcg     4980

cttgaacctg ggaggcagag gttgcagtaa gccaagatcg caccattgca ctacagcctg     5040

ggcaacaaga ggagcgaaac tctgtctcaa aaaaaaaaaa gagaaagaat ataaagtgaa     5100

tctgaatctc cactcaaggg gatggcccca aggatattgt agctggtaat ttcttcatgc     5160

cactaggtgt ccccagtgtt caacctccat gactgagatt ggaagaagta gagttaaaag     5220

tttttactac ctttgagaag cctgcgggca tgttcacagt cgtcccatgc cagccaggtt     5280

ctgaggctaa ctgcttgtgc ccctgctgct tcacatggca ttgtgggagt tgctgatact     5340

ggggaaatga tggcagatct gaccaagtgg tgctgagaaa accaccctcg gccttgcaga     5400

ctccatagtt tatctcaagg cagtgccagt cggatttggt gctaaaggca taaggccaag     5460

tcagcctctg atattggcac aaaagaatgg tctcatgcca gtagcattga actgctgagc     5520

ttgggaaggc ttaaggctcc cacacacaga ctgagaatga tgggggtccc tctgcgtctg     5580

ctaattagac aaacattcta tatctagtgc caaaagtggt cctaaatcct ttggcaaggg     5640

tcctttctgc tctcatgctg atttggggga ggactgggca tcctgcctca ggagaacttg     5700

agtcctgagg aaagggccct agtaacactt aagggctacc cctggctaac agatactcgg     5760

ctgtgggtga gagcagaagg tcttggaccc ctcgatgtgc aggtacttaa ttgtgtttcc     5820

agtgcatttt catatacatt atcccattta acctttataa caggttcaca gagtggatat     5880

tcccattctg ttgatgagaa aaagagtgga gagactgtgt ccagtgtcag caggaagaaa     5940

aaagatctgt tggaggccag tacatgttga cagaaactct agaccatatt ttgtctcctg     6000

tctttggcca aagagaacta gcttcagtct gaaaagggca gggctaagtg gttacaagga     6060

actaaaaagt tcaaggtaag acaaatgagg taaaaataaa aaagagcact tagctgctct     6120

gagacatttt agtctcctga ctggtaaaca gcagctgggg caccaagggg ctcccaggag     6180

tttgtcgagc ttttattgga gtgaactgaa aggaaaatgg aaggaatgct ataagactga     6240

aaagaagtta aagccctagg aaggaagctg ataacacaag ttacagacgt atatgtgaca     6300

ttgatttggg agaatgaacc tacaacaaat gacccaaaag cacctaaata agagtgacga     6360

gagtttaaca gacattcatt atggacttca gagaaaatga tgctaaactg gtcttagaat     6420

cttctttaat tttgttaact aggtaaataa tctggacatt ttagtcaaag cattagacag     6480

acagagaagt tggtaactga ccactaacta acaaactata aattcaccca ttgtgggttg     6540

acctggtaag ttcccccagg gctgtgtcct tggcccctcc tttgatatta gtgacagatg     6600

acttttttta tgccttaccc attccacaaa agaatttgaa gccatttaca caagagatag     6660

tactagtaaa ttaggagtgc tgatcaaatt tttagataat aagaaaccct taggaaggat     6720

gacaatttag aatccaaatt taggatccaa acaaatacca ttacaaacta taaaaatgag     6780

cagaatctaa atgtaacatt tcaataaatg cagattgata ataacatctg tgcagagttg     6840

aggactatag agtactgtgc tgtcactaac agtattgtgt gctactaaga gtttaatggc     6900

tgggtgtggt ggctcacacc tgtaatccca acactttggg aggcctaggt gggtaaatca     6960

gctgagatca ggagttcgag accagcctgg ccaatgtggt gaaaccccgc ctctactaaa     7020

aataaaaaaa ttagctgggc atggtggcac gtgcctgtaa tcccagctac tcgggaggct     7080

gaggcgggag aatcacttga acctgggaga cagaggttgc agtgagtcga gatcacacca     7140

ttgcactcca gcctgggcaa cagagcaaga ttctgtctca aaaaataaag tttattatgc     7200

caggagggcc aggtgtggtg ccacacccat gtaatcccag cactttagga ggctgaggag     7260

ggcagatcac ttaagcccaa gagtttgaga ccagtctggg caatgtggca ataccttgtc     7320

tcttaaaatt taaaataaaa aaaaagttta ttatgccagg aactgttaat gtgtccaaaa     7380

aaactccagt gtggttctag gatgagataa taaaaacagg ttgtctaggg tagtgtggaa     7440

ggtcctttca gtcttcctgt gcctatcagt gatcctcatt gccatgttcc cttctggtgc     7500

tcaaccggag gctccctgac agatgagtcc tctgccagag gaaggctaag atgtagagga     7560

caaatcgtgt caaggaaaag aagcttgaag gagctaagaa tgcttagctt agagaagaca     7620

agaggaaaca ggacatggct ttgggaagtt caaggatggt ccagtgaaat acatactata     7680

cttttgcacc ccagctaagc tgacccatga tcagtaagta ggaaataaaa ggccaatttc     7740

tggctactct tgcccccaac cccatttcag tgaactatga acctctatta gatatgcaag     7800

gccggtgcta aatgctggag ggctttggcc ctttccctca aggagctagt ctagtagggg     7860

gtcagaaata cagatgggcc tgaacataat gatggtttga cttccagttt ttcaacttta     7920

ggattgtgca aaagctatac acattcggta gaaacagtac ttcaagtatc catacaatca     7980

gtacagtatt caataaatta catgagacat tcaacacttt attataaaat aggctttgtg     8040

ttagatgagt ttgcccaact gtaagctaat gtaagtgatc tgagtaggtt taaggtagcc     8100

taggtgtatt aaatgcattt ttcacttaac ggtattttca acttttgttg ggtttattgg     8160

gatgtagccc cattataagc tgaaaagcat ctgtagtata ataaatgtgg ggagtgctgt     8220

gagagaaata agtgtactgg gtttagttcc cactgcccaa aaaaggaact ggctaatggt     8280

aacctggggg aggaagtcgg gtaagttgca tggagaaggc aacccttgaa cacttgcaag     8340

gagctaacaa tacctgcttc tggagtattt aaacgccagt gggtatgcta aatactttta     8400

cctcagacca cctactaacc ttacaaagta gtccactttg ctcacccagt tttacagatt     8460

gatgaaactg aagcagacag atattgttaa cctatcaaag gtcaccctgc aagtgtgtga     8520

ttatagtcca agcagcttgt acttgttgcc tatttgtttt gcctttcctg tgcatttgcc     8580

aggcagatga gagtggggta agacattgca gagaaaaagt aagaaaaggc cgtcatgaaa     8640

caatttcatt ttcagacctt ataagcacgt tacaagtact gatatttatg cttaagttca     8700

cgggagtcct ggccagaaat aaagctggaa ggacaagtgg ggggcagatt gtgaaggatc     8760

cttcaagacc tgcttcctct agagaatggg agactaccca agataactaa acagggaagt     8820

gatcaggttt tgtgtcttag aaaagtgttg cagtgttgat gcaaatgtga ctagaagggt     8880

gacttggaac ctggattgaa ggggtgggag atgggagaaa ggaatgcagt ctggcagcag     8940

ctacagcagt ccaggtggga aaacccagag cctgaactaa ggttgtaact agaggggata     9000

gggtggaaga gctggattag agatgttgac aagataaagt cagtaggact taaagactga     9060

caagtaagga ttttccaaaa gtgagagctg tggaatgaat tgtcttaaaa tgttgcagtg     9120

agttcctcct catcaatcca agtgctcgat cagaggctag acctttagtt agcagtcacg     9180

ggaaaattcc ccattctcac ggggatttag actaggtctt aaccatactt taccaagatt     9240

ccagtagcaa agcacccaaa agtaatcgca ataaaattcc aatttttgta ggccgggcat     9300

agtggctcac acctgtaatc ccagcacttt gggaggccga ggcaggcgga ccacgacatc     9360

aagagttcaa gagcagcctg gccagcatgg tgaaaccccg tctctactaa aaatacaaaa     9420

aaattagctg ggcatggtgg cgcatgccta taatcctagc tactcaggca gctgaagcag     9480

gagaattgct tgaacccggg aggcagaggt tgcagtgagc caagatcatg ccactacact     9540

ccagcctggg cgacagagcg acactctgcc tcaaaaaaaa aaaaaaacaa aaaaaaaaac     9600

aagttttgtg aatttaagtt tccctaatgg atggtacagg tcaacatttg ccatctaatg     9660

acacttacat tccagttttt tccttttttg agtaactggg aaaagggtgg cattactgct     9720

ggcttcctaa aattgaaaag tatactaggg tttttaaacc tgtgtagaat acatgatatg     9780

gtagcaaatg tgctgtagga agaaaagcaa tgaggaacta ctggcctgac taggaggcct     9840

agaagtccct cccaggcttg agttgttctg acttggcatg attacatagc tgcggcaagt     9900

gacgtttcct tcaagccttg gttccctcat ctgtaaaata gggaactaat acctacctca     9960

caggattgta gttagaatta aggatgactt cattaaagca cctctagtgg tggaagatgt    10020

cccatcctat cccccaccca tagctgggag ctatgtttgg ctcattcttc ctgactcact    10080

ggattacact gtgactcagt tcaatttcac acatgctgct gctaaattag ggtcttggtg    10140

agcctttggg aggacagctc tgaggaatga attgtagcac tgcagccctg cctgaggaac    10200

atgatagaaa caggtggtag gcccagctct tgccttccac ctactaagca gtttttctgt    10260

ggttagctgt gtgacataaa ctatcggtgt attaatttgc tttcactaga ttcccccccc    10320

cccaacaact tagtccaaga acatacctga attctttgca tttccttgcc ttagttgctt    10380

ttgtagggtg gacagcagga ctgcatgaga atagctgtgc ttctggaccc tatggtgaaa    10440

gctctagtga actgcaatta ggcccagggt cccggaggaa gaaggggaga gaaaaagggg    10500

ggtagttttc caaaagataa gtaggggaca aaaaagtcca cggggcctat gagcggtgag    10560

actcctgccc tgattgtggc aaagcacctg gagatgatag aacttcctag ggaaaaggct    10620

gcatggagtc cccagggatg ctgggccctg gtcaccaagg ctccctggga aggtctcttg    10680

tacctggggc acacagacca acacttctga atttgcaagc ttaagagcat gtatgagcag    10740

aacctgtgca gaccaaggct tagagggctc acctcaatgt tttgcactgt gtgagacccc    10800

aggacctttt cgtgattctg gagaggggaa caaaccataa taacaacaaa ccaggtagca    10860

ggatagagac tcattctcat ctattttggt taaaagaaaa taaatgtatt tcttccacac    10920

ctgattttgt gattgcaaat tcataactaa tatccctcgt cagctccgct gactcatccc    10980

tgccacaggg aggttcacag caagagcaca gaaactaggg ccagtgcccg gttgtgtgac    11040

cttgagtaag ttctttttcc cttgaacagg gagagagaca caatggatca gagtgtctct    11100

gccagttcta acttggggat tctagtgggt tgaaccgaac ggtagtccgt ttccaaaaga    11160

ggaagccaag accagagggg gagtggttcc ttcaagtttg cagaaccagt aagtggcaga    11220

gcaggactca tatctagtta gtggttcaga gcatgggctc cggagctaga ctgcctggat    11280

ttgaaccctg gctttgccac ttgcctgttg ggtgactttg gacaagctgc ttaaattatg    11340

tctccatttc ctaatccaca gaacaagtgt aatactagtt atctgtttca tggagtgatt    11400

gtgaggatta aataaagtta atataacaca aagca                               11435


<210> 1534
<211> 401
<212> DNA
<213> Homo sapiens

<400> 1534
cttccgccag cttccctcct cttcctttct ccgccatcgt ggtgtgttct tgactccgct       60

gctcgccatg tcttctcaca agactttcag gattaagcga ttcctggcca agaaacaaaa      120

gcaaaatcgt cccattcccc agtggattcg gatgaaaact ggaaataaaa tcaggtacaa      180

ctccaaaagg agacattgga gaagaaccaa gctgggtcta taaggaattg cacatgagat      240

ggcacacata tttatgctgt ctgaaggtca cgatcatgtt accatatcaa gctgaaaatg      300

tcaccactat ctggagattt cgacgtgttt tcctctctga atctgttatg aacacgttgg      360

ttggctggat tcagtaataa atatgtaagg cctttctttt t                          401


<210> 1535
<211> 5350
<212> DNA
<213> Homo sapiens

<400> 1535
ttctcgggag aggaatcggt taggagaagg gggattcctc actcagctgt gcgctctgat       60

ttcgtgcgct tcctcgtcct tcatgttgga tggccagttt ttcgtttgtg cgtcatcctc      120

tacctgagaa atggtcgctt gcccctagtc tagacacgca ttaaagggca gtatttaaag      180

tcagttggca agcagtggaa taagattttt gtaaagaaac cttgtgcagc atggattctc      240

taccagatga attttttgtg aggcatcctg ctgtggagga tcagaggaag gaagaaactg      300

agaataagct agaaaaatca tctggtcaac tgaacaaaca ggaaaatgac atacctactg      360

atcttgtccc tgttaaccta ctattagaag tgaagaagtt attaaatgca attaatactc      420

taccaaaagg tgtggttcct cacattaaga agttcttaca agaagatttt tccttccaaa      480

ctatgcagag agaagttgca gctaacagcc agaatggtga ggaaattgtt cctgctttga      540

ctttacgttt cttgattaca cagctagaag cagcacttag gaacattcaa gctggcaatt      600

ataccgcaca ccagattaat attggttatt atttgacatt actgttttta tatggagtag      660

cactcactga aagaggaaag aaagaggatt atacagaagc tgagaataaa tttctggtga      720

tgaagatgat gatccaagaa aatgaaattt gtgaaaactt tatgtcttta gtttattttg      780

gacgtggttt actgcgatgt gctcaaaaga gatataatgg aggactgcta gaatttcata      840

aaagcttaca agaaattgga gacaaaaatg accattggtt tgacatagat cctacagaag      900

atgaagattt acctacaact tttaaagatc ttcttaataa ttttatcaag acaactgaaa      960

gcaatataat gaagcagacg atttgtagtt acctagattg tgaacgatct tgtgaagctg     1020

acattttgaa gaacaccagt tataagggat tttttcagtt aatgtgcagt aaaagttgct     1080

gtgtttattt ccataaaatt tgctggaaaa agttcaagaa tttaaagtat ccaggtgaaa     1140

atgatcagag ttttagtggg aaaaaatgtt tgaaggaagg atgtacaggt gacatggtaa     1200

ggatgctgca atgtgatgta cctggaattg ttaaaatttt gtttgaagtt gtgagaaagg     1260

atgaatatat caccattgaa aatttaggag caagttatag aaagttgata tctctgaaaa     1320

taactgatac tgatataaga ccgaagatca gtttaaaatt taatacaaaa gatgaaatgc     1380

ctatcttcaa gcttgattat aattatttct atcatctgct tcatataatt attatttctg     1440

gtactgacat tgttcgacaa atatttgatg aggctatgcc acctcctctt ttgaaaaaag     1500

agcttcttat acacaagaat gtgctggaat cctactacaa ccatctttgg accaatcatc     1560

ctttgggtgg atcatggcat ctgctttatc ctcctaacaa ggagttaccg caatccaaac     1620

agtttgactt atgcctcctg ttagctctta taaaacattt aaatgtgttc cctgcaccca     1680

aaaaaggatg gaatatggaa ccgccatctt ctgacatctc taaatctgca gacatcctga     1740

gactgtgcaa atacagggat atcctcctta gtgagatttt gatgaatggt ctcactgagt     1800

cacagttcaa ttcaatttgg aaaaaagttt cagatattct tctgcgcctt gggatgatgc     1860

aagaggatat tgacaaagtg aaggagaatc ccattgagaa tatctccctt gattaccatc     1920

agctatctgt ctacctaggc ataccagtac cagaaatcat acagaggatg ttatcctgct     1980

atcaacaagg aattgctcta cagtcaataa caggcagtca gcgtattgaa atagaagagt     2040

tacagaatga ggaagaagaa ctaagtccac ctctcatgga gtacaatata aatgtgaaat     2100

cacaccctga gatacagttt gcagaaatta ataaagatgg gacctcaata cccagtgaat     2160

cttcaacaga atctcttaaa gatctccagg aagttaagag taaacaaagg aaaaagaaga     2220

agactaagaa taaaaagaat aaagactcaa aagaagacca agtcccatat gtggtagaaa     2280

aggaagagca gttgaggaaa gaacaagcaa atccacactc agtcagtaga cttataaaag     2340

atgatgcaag tgatgttcaa gaggattctg caatggaaga caagttctat agcctggatg     2400

aattgcatat tctggacatg atagagcagg gctcagctgg caaagtaact acagactatg     2460

gagaaactga aaaggaaagg cttgctcgtc aaaggcagct ttataaattg cactatcagt     2520

gtgaagattt caaaagacag ttgagaacag tgacttttcg gtggcaagaa aaccaaatgc     2580

agattaaaaa gaaagacaaa attatcgcat ctcttaatca acaagttgct tttggaatca     2640

ataaggtttc caaattacag cgtcaaatcc atgctaaaga taatgaaatc aagaacctta     2700

aagagcaact ttctatgaaa agatctcagt gggaaatgga aaaacataat ctggaaagca     2760

caatgaaaac atacgtaagc aaactgaacg cagaaactag cagagcttta acagccgagg     2820

tgtatttctt acagtgtcgt agggattttg gtttgcttca tctagagcag actgaaaagg     2880

aatgtctcaa tcagcttgcc agggtgactc acatggcagc aagcaaccta gaatcacttc     2940

aattaaaggc tgcggtagac agttggaatg ccattgtggc agatgttaga aacaagattg     3000

cattcctcag gacacagtac aatgaacaaa taaacaaagt caagcaagga tttgccttga     3060

gtaccttgcc tccagtccag cttcctcctc caccacccag tcctgagata ctgatgcagc     3120

agttcttagg aagacctctt gtgaaagaat ctttctttag acccatactt actgttcctc     3180

aaatgcctgc agtttgcccg ggagtcgtct ctgcaactgg ccaacctaga gcccccctga     3240

tgactggcat agcctgggct ctgccagcgc ctgtgggaga cgctgtgcct cccagtgcag     3300

gtctgcggag tgatccctcc atcatgaatt gggagagaat tacagacagg ctgaaaactg     3360

cctttccaca gcaaaccaga aaggaactta cagatttctt acggaaattg aaggatgctt     3420

atggaaaatc cttgtctgaa ctgacatttg atgaaattgt ttgcaagatt tcccagttta     3480

ttgaccccaa aaagtctcag agtcaaggaa aatcagtgtc aaatgttaat tgtgtttcac     3540

ctagtcattc tccatcacag cctgatgctg cccagccccc aaaaccagcc tggaggccac     3600

tcacttcaca gggtcctgcc acatgggaag gagccagtaa tccagatgag gaagaggaag     3660

aagaagagcc ttgtgtgatc tgtcatgaga atctgtctcc agaaaatctt tcagttttgc     3720

cttgcgctca caaattccat gctcagtgca ttagaccatg gttgatgcaa caggggacat     3780

gtccaacgtg cagactccac gttttgctac cagaagaatt ccctggtcac cccagccggc     3840

agttgcccaa gatctgatac aaggtaccca tgaagagatt atgaactact tgaaggtgga     3900

gactgtacgg tggtgtgttg gagctggctt gtaatgtctt atgagtgaca atcgttagtt     3960

tgaggaattt tgtgagacag ttgtcaaatt gttgctagct tgaaatctgc ggcaattgga     4020

gtatttacac catagaaatg ctataagtga agacctacct ttcccttaag agctagttgt     4080

taaaccttta ccagcatacc actggacctt gtctaaaatt tctttgtgtt cccagtgtct     4140

tgcccagtag atacaagata aatattgcca gaatcagata tcaggaagta gtaagaaaag     4200

gagttaatat gcaaactaaa tcactcgctc aattgaataa ttgagatctt ctgttcattt     4260

gttccttgga ccttaatcat ttgcattttg gagaaaattt tttctgcttt aaaagtctgt     4320

aatttcagtt tttgtgtcgg ggagagggaa aaactatttg tctgtagttg ctttttgtga     4380

caaagtgaat acccactggg ctaagtttca tatctaaagc ttgtcactaa gaattttcat     4440

ttttaggggt caaaaaccta ttttgaaaat agtgttgtgt gaatgctgta agtgttgtac     4500

atgtctctgg tttcagaatt aaaagaattc agagttacct tgtgagataa atgttctttg     4560

cttcatattc acagtttcac ctccatttaa atttatgggg aagaataaat gtttcctgac     4620

tcagaaacaa ttttgcctcc atatttcagt gcaaatatat tttgaagtta cttttaaata     4680

tttatttaaa acctctgttt ctgtaactgt atgttaaacg tattcttctg taatgagaat     4740

agactggaac atgtgaggga aaaatattta aaaaaagatg gcagtcatct agacatgtaa     4800

aatgccaaga atgtcttaga attgcacaat ttagaattta tagagccttt aatcaccttg     4860

tctagcacct tgtattagtc cattttcatg ctgctgataa agacatacct gagattgggc     4920

aatttacaaa agaaagaggt ttaacggact tacagttcca catgactaag gaggcctcac     4980

aatcatggtg gaaggcaaag aggagcaagt cacatcttac atggatggca gcagacaagg     5040

agagagagct tgtgcaggga aactcccatt tttaaaacca tcagatctca tgaggcttac     5100

tatcacgaga acagcatggg aaagacctgc ccccgtgatt aaattatttc ccaccaggcc     5160

cctcccacaa catggaataa tgggagatac aagatatttg ggtggagaca cagagccaaa     5220

ccatatcaca ccttaaggtc atggtcatat agctagttat cttgtaaaac caatgtttct     5280

tagttcatac ttacaactgc aatttcactt tcatttagaa aagaataaat gtttcttaat     5340

tgaacaacta                                                            5350


<210> 1536
<211> 1710
<212> DNA
<213> Homo sapiens

<400> 1536
ttcttttctt tcaacacttt aaccatgtca ctccatgggg acgctgtctt gagcctttgg       60

taagcctcat tctccaggac cacacggcag gcgcgacagc cctaggtcca ccccaccccg      120

taagcgctcc ctccgggagg agacagaaac ccaggacagc tccggggcaa ggccgaggaa      180

ggagggacga cggggcaggg aggcccgaag agtccccgcc ttttgggata gtcgccaccc      240

ttggaccccc tcacccttgg ggacgttgag gagtgttaaa atctccaaga cgcgagtcac      300

cggtacgaag ccacagccat ttcgctgctt gctcggtgca agtgcagaag gtcctagtag      360

ccgagcgtgg agtcgagctc gtgggcggcg tcgggcacct tcggccgcgc cctcagctgc      420

acccgccggt gggcggggcc cgagcccgtc tctaaagcca cgaggccgcc cgctccgagc      480

ctggtgcttc cgaccgctgc gcgcggctcc tgggctgtca cagtctcccg ttgccgccgt      540

catgtcccgg cagctgtcgc gggcccggcc agccacggtg ctgggcgcca tggagatggg      600

gcgccgcatg gacgcgccca ccagcgccgc agtcacgcgc gccttcctgg agcgcggcca      660

caccgagata gacacggcct tcgtgtacag cgagggccag tccgagacca tccttggcgg      720

cctggggctc cggctgggcg gcagcgactg cagagtgaaa attgatacca aggccattcc      780

actgtttggg aactccctga agcctgacag tctccggttc cagctggaga cgtcactgaa      840

gcggctgcag tgtccccgag tggacctctt ctacctgcat atgccagacc acagcacccc      900

ggtggaagag acactgcgtg cctgccacca gctgcaccag gagggcaagt tcgtggagct      960

tggcctctcc aactatgcag cctgggaagt ggccgagatc tgtaccctct gcaagagcaa     1020

cggctggatc ctgcccactg tgtaccaggg catgtacaat gccatcaccc ggcaggtgga     1080

aacggagctc ttcccctgcc tcaggcactt tggactgagg ttctatgcct tcaaccctct     1140

ggctgggggc ctgctgaccg gcaagtacaa gtatgaggac aagaatggga aacagcccgt     1200

gggccgcttc tttgggaata cctgggcaga gatgtacagg aatcgctact ggaaggagca     1260

ccactttgag ggcattgccc tggtggagaa ggccctgcag gccgcgtatg gcgccagcgc     1320

ccccagcatg acctcggcca ccctccggtg gatgtaccac cactcacagc tgcagggtgc     1380

ccacggggac gcggtcatcc tgggcatgtc cagcctggag cagctggagc agaacttggc     1440

agcggcagag gaagggcccc tggagccggc tgtcgtggac gcctttaatc aagcctggca     1500

tttggttact cacgaatgtc ccaactactt ccgctaggcc catcgtttct caggctgccc     1560

aaggctcttc tgtaacatct tttgttactc acattttctt taatttagaa ctgcctcagt     1620

aaattcttag ggatggaagt atttggacaa aaacctaata gaagagtcac caccaaatga     1680

agaataaaac tcccagggtg ctgtgtgtta                                      1710


<210> 1537
<211> 1686
<212> DNA
<213> Homo sapiens

<400> 1537
ggtacctgta ccccacgtag tcgccggtta ccgatcggac taagttccag tggtgattta       60

caagtcaagt taaaatgtcc ccagaagtgg ccttgaaccg aatatctcca atgctctccc      120

ctttcatatc tagcgtggtc cggaatggaa aagtgggact ggatgctaca aactgtttga      180

ggataactga cttaaaatct ggctgcacat cattgactcc tgggcccaac tgtgaccgat      240

ttaaactgca cataccatat gctggagaga cattaaagtg ggatatcatt ttcaatgccc      300

aatacccaga actgcctccc gattttatct ttggagaaga tgctgaattc ctgccagacc      360

cctcagcttt gcagaatctt gcctcctgga atccttcaaa tcctgaatgt ctcttacttg      420

tggtgaagga acttgtgcaa caatatcacc aattccaatg tagccgcctc cgggagagct      480

cccgcctcat gtttgaatac cagacattac tggaggagcc acagtatgga gagaacatgg      540

aaatttatgc tgggaaaaaa aacaactgga ctggtgaatt ttcagctcgt ttccttttga      600

agctgcccgt agatttcagc aatatcccca cataccttct caaggatgta aatgaagacc      660

ctggagaaga tgtggccctc ctctctgtta gttttgagga cactgaagcc acccaggtgt      720

accccaagct gtacttgtca cctcgaattg agcatgcact tggaggctcc tcagctcttc      780

atatcccagc ttttccagga ggaggatgtc tcattgatta cgttcctcaa gtatgccacc      840

tgctcaccaa caaggtgcag tacgtgattc aagggtatca caaaagaaga gagtatattg      900

ctgcttttct cagtcacttt ggcacaggtg tcgtggaata tgatgcagaa ggctttacaa      960

aactcactct gctgctgatg tggaaagatt tttgttttct tgtacacatt gacctgcctc     1020

tgtttttccc tcgagaccag ccaactctca catttcagtc cgtttatcac tttaccaaca     1080

gtggacagct ttactcccag gcccaaaaaa attatccgta cagccccaga tgggatggaa     1140

atgaaatggc caaaagagca aaaagagaga gcaacagaga tggggaggaa tccagctctg     1200

cctgacatcc aggcatcctc tccaaattgc atagggctta tttcaaaacc tttgtccctc     1260

agttccagga ggcagcattt gccaatggaa agctctagga aacaccagtc ttgagaggtg     1320

gccagccaga ctgcctgtcc acatgcgtgt cagcacatac agccgcttcc tggaagccgc     1380

ctggaatgtc ttcacggcag cgttttgctc acacagcagc ttttgcacgc cccaggcagc     1440

cccgactgct gaaatccaac ttgagctggc tggtggtccc tggatcctag agcccttcac     1500

ttcgggttac tccctctttc ttgcctctat ttcttagttg gaagaaataa actcacaaat     1560

tatggtgcag taattttccg gggaaagtaa agcctcagga atgcccacgc ctttcttcca     1620

aagcctttgt ctctgagacc tcttaagttc taagattaaa tgcccctcgc tgttcttcct     1680

ctgaaa                                                                1686


<210> 1538
<211> 4730
<212> DNA
<213> Homo sapiens

<400> 1538
gagaacggtg gccggacgga gagactgcgg gtctgaggga ctggcgggcg ggcgggccga       60

gcggcgccgc cgaggccggg ctgggccgag cccaggagcg cccgggatgt agcgggccac      120

cctgccgatg ccacagcgcc cggccgcggg cggagccgga gccggagcct ggggaggcgg      180

cgggggccca gagcgcagcc cgcgcccccc gcgcggagcc aggcccgctg ccgtccccgc      240

cgcccgggcc cccggcatgc agccccggct gcggaggtga cactcacgga ccttagccac      300

cgccgccgcc atcgccacca tggacgaaca ggaggcattg aactcaatca tgaacgatct      360

ggtggccctc cagatgaacc gacgtcaccg gatgcctgga tatgagacca tgaagaacaa      420

agacacaggt cactcaaata ggcagagtga cgtcagaatc aagttcgagc acaacgggga      480

gaggcgaatt atagcgttca gccggcctgt gaaatatgaa gatgtggagc acaaggtgac      540

aacagtattt ggacaacctc ttgatctaca ttacatgaac aatgagctct ccatcctgct      600

gaaaaaccaa gatgatcttg ataaagcaat tgacatttta gatagaagct caagcatgaa      660

aagccttagg atattgctgt tgtcccagga cagaaaccat aacagttcct ctccccactc      720

tggggtgtcc agacaggtgc ggatcaaggc ttcccagtcc gcaggggata taaatactat      780

ctaccagccc cccgagccca gaagcaggca cctctctgtc agctcccaga accctggccg      840

aagctcacct ccccctggct atgttcctga gcggcagcag cacattgccc ggcaggggtc      900

ctacaccagc atcaacagtg agggggagtt catcccagag accagcgagc agtgcatgct      960

ggatcccctg agcagtgcag aaaattcctt gtctggaagc tgccaatcct tggacaggtc     1020

agcagacagc ccatccttcc ggaaatcacg aatgtcccgt gcccagagct tccctgacaa     1080

cagacaggaa tactcagatc gggaaactca gctttatgac aaaggggtca aaggtggaac     1140

ctacccccgg cgctaccacg tgtctgtgca ccacaaggac tacagtgatg gcagaagaac     1200

atttccccga atacggcgtc atcaaggcaa cttgttcacc ctggtgccct ccagccgctc     1260

cctgagcaca aatggcgaga acatgggtct ggctgtgcaa tacctggacc cccgtgggcg     1320

cctgcggagt gcggacagcg agaatgccct ctctgtgcag gagaggaatg tgccaaccaa     1380

gtctcccagt gcccccatca actggcgccg gggaaagctc ctgggccagg gtgccttcgg     1440

cagggtctat ttgtgctatg acgtggacac gggacgtgaa cttgcttcca agcaggtcca     1500

atttgatcca gacagtcctg agacaagcaa ggaggtgagt gctctggagt gcgagatcca     1560

gttgctaaag aacttgcagc atgagcgcat cgtgcagtac tatggctgtc tgcgggaccg     1620

cgctgagaag accctgacca tcttcatgga gtacatgcca gggggctcgg tgaaagacca     1680

gttgaaggct tacggtgctc tgacagagag cgtgacccga aagtacacgc ggcagatcct     1740

ggagggcatg tcctacctgc acagcaacat gattgttcac cgggacatta agggagccaa     1800

catcctccga gactctgctg ggaatgtaaa gctgggggac tttggggcca gcaaacgcct     1860

gcagacgatc tgtatgtcgg ggacgggcat gcgctccgtc actggcacac cctactggat     1920

gagccctgag gtgatcagcg gcgagggcta tggaaggaaa gcagacgtgt ggagcctggg     1980

ctgcactgtg gtggagatgc tgacagagaa accaccgtgg gcagagtatg aagctatggc     2040

cgccatcttc aagattgcca cccagcccac caatcctcag ctgccctccc acatctctga     2100

acatggccgg gacttcctga ggcgcatttt tgtggaggct cgccagagac cttcagctga     2160

ggagctgctc acacaccact ttgcacagct catgtactga gctctcacgg ccacacagct     2220

gccggtcgcc ctttgctgca tggcaggggg ctgctgctgg gctcagtgaa gttgctgctt     2280

ctcccaggca aggctgtgga ccatggagtg gcagcccagc cagcgtcggt ctgtgcccct     2340

tccgccactg gggctcagag ccggggtggg gtggctgcag cctcaggact gggagccccc     2400

agcctgtcag atccaggagc tccagtgtcc tgagctcagc gtggaggggt aggggctggg     2460

aacagtgtgc aaggcagccg tgggccccac cctcggggat gtgtcctgac actgcaattg     2520

gcaccgaagc ccagagggtc tgggggcaca agactgacgc cagggtatga agagtgttat     2580

tttcattcaa agtgttattt tgtttttcct tccaatgtct ggagaccacc agggcatctc     2640

tgggctggat gagctcccac aagcctgagg gaaaggccag cactcgctag cagtggcagg     2700

cagaggccca ggctgccgtc ccctagagtc ccaggttggc tctgccagtc ctgtccttta     2760

ccaaagatga atgaagcaaa tgtcatgctg ccttattcag ggaaggagga gcctgtcctg     2820

cctgtggcca tgaccctgcc tctcccaggc aggggcccgc gatgtggaac tgctgccact     2880

gaggggggat ccagttttgt caatgcagtt gtctctgttt tacaagttgg agtcactctt     2940

atgctgtacc cagtttctaa actggagact gtgtgtgccc tctgggctct gagtacccct     3000

gctttgggct tgggcctagg ctgcattgaa aagagctgaa ggttgtggcc tttgcgctcc     3060

tggcccagcc tttgttcccc actggagcag aaggggagat ggacgacacg gtcggggcat     3120

ctggcctggc cagtgccctg atcccagaga gcccgaggag gtgtctcagg ctgcctgagt     3180

cgtgacctgc taggccagag cccactccat ctggtagaag ggaaagccca tatgctacca     3240

ccagctgtgt ccaaaaccgc cagctctgtt cttcctcagc cagcctcgcc catccccttg     3300

aggtctcagc ccctttccct tgtagctcct cccctggagg gggaatggca gcaggggttg     3360

gggaaacagc atctccaagc agcttagagt tggccatatt tacctcagcc tgggcgctgg     3420

tcctttcttc cggcccctcc cctccaaaat gtgcctattg ctagagctcc tccctctcaa     3480

cacccagttt ccttgggagt tgtcattaaa ggaaaaaaaa aaaaaaaaaa gccagtgccc     3540

agggatgggc atctccaggg agctggggat tagtgccagg cagccctgcc agccatgcct     3600

acatccccat gggcacagaa caagccaaag ccttcgttgt atgttgacga tgcactttta     3660

tgaatgtagt ttctatcgct gtttttagcc ttttcacatc atgtaatgtg aggccttgta     3720

cttgttaatt tatatctcag atcatatttg atggttttta tatatatcaa ttctagactg     3780

ttacaggtga cggacgcctc aagagagaga agagaaaatg aaagcagctg gttttgcaga     3840

agtgtgtgtc gcatgcgcca gttgggcctg gaccctcctg tgtccatccc tgttccccca     3900

ggggctctat cagcccctgt accccacact gccctctgaa gacaacacag gctcctgctt     3960

ccacctcggc ccttgcccag ggtggggcct ggccctcatc ttgaccaaag ctgctgtgtg     4020

gcagctcggc ctctctacga ccccatcttg gtggctgcac actcttcctg gcccgcaccc     4080

ccatccccag tccctgttcc ccaagaggat acagagcacg gtgctggctg actcaactgt     4140

gcgtcccagg ttcagggtct tacagagctc caccccctgg ggtcttacct cactgggaat     4200

gtgttttgaa aatgaatttg aagacaagcc aacaaaccct gcactccaaa aaagcaaaac     4260

agaccctaat ttttttgtgc caaaaactgt ggacatgctg gctcagcatc ctcaggacca     4320

agttgttgct taatttattg ttttttaata actaatccag ataaaaagtt gtggggcttc     4380

agggtgacct gggcccaaag gttctgaagg gcagttcctg gcagccccag gcttgctgtg     4440

ggaaggggcc gtgccgtcac tttctcatca ttccatgggg tgtgtctgcc tgggccaact     4500

ctgcatggag aggccagggc tggggacagt ccgcactctg ccaccctcct gccccttcca     4560

cccaccccag ctctatgtct gtgtctgaat tgtggatcgt gcagccatgg ttattgtgga     4620

actgtggaac ctgcagccat agttatttga ctatatcttg accgagggct tgcagtgcaa     4680

agccaggcca gtgttgcgca ttacttacaa taaaagggat catttatatc                4730


<210> 1539
<211> 3009
<212> DNA
<213> Homo sapiens

<400> 1539
actgctcctt ctctcacgcc aactgagtct cttgatctgt acatgcaatc ccaggcagct       60

cgcgaacaca aacccggggc cagccgccta ctgctgctgc tgctgctgcc gctgccgccg      120

ccgccgccgc cgctgcctcc gccggctctg cgaacccggg acttttcatg caccacactc      180

tccgcctgct tccctccgtg tcctgaaaag tgcgaccgtt ctcccaagga atttccacgg      240

caagtcttag gagggaatga ttccccagta atattccctg ccctgaccca aagtgctggt      300

tggcctccct cccagggaag actgcttctt gcgtaacgcc ggccacagaa agagactccg      360

atggacttac accgggcagc cttcaagatg gagaactcat cctaccttcc caaccctctg      420

gcatccccag cactgatggt cctggcatcc acggctgagg ccagccgtga tgcttccatc      480

ccttgtcagc agccacgacc ctttggtgta cctgtctcag ttgacaagga cgtgcatatt      540

cctttcacca acggttccta tacctttgcc tctatgtacc atcggcaagg tggggtgcca      600

ggcacttttg ccaatcgtga tttcccccct tctctactac acctccaccc tcaatttgct      660

cccccaaatc tagattgcac cccaatcagt atgctgaatc atagtggtgt gggggctttc      720

cggccctttg cctccaccga ggaccgggag agctatcagt cagcctttac gccggccaag      780

cgacttaaga actgccatga cacagagtct ccccacttgc gcttctcaga tgcagatggc      840

aaggaatatg actttgggac acagctgcca tctagctccc ccggttcact aaaggttgat      900

gacactggga agaagatttt tgctgtctct ggcctcattt ctgatcggga agcctcatct      960

agcccagagg atcggaatga cagatgtaag aagaaagcag cggcattgtt cgacagccag     1020

gccccaattt gccccatctg ccaggtcctg ctgaggccca gtgagctgca ggagcatatg     1080

gagcaggaac tggagcagct agcccaactg ccctcgagca agaattccct tctgaaggat     1140

gccatggctc caggcacccc aaagtccctc ctgttgtctg cttccatcaa gagggaagga     1200

gagtctccaa cggcatcacc ccactcatct gccaccgatg acctccacca ttcagacaga     1260

taccagacct ttctgcgagt acgagccaac cggcagaccc gactgaatgc tcggattggg     1320

aaaatgaaac ggaggaagca agatgaaggg cagagggaag gctcctgcat ggctgaggat     1380

gatgctgtgg acatcgagca tgagaacaac aaccgctttg aggagtatga gtggtgtgga     1440

cagaagcgga tacgggccac cactctcctg gaaggtggct tccgaggctc tggcttcatc     1500

atgtgcagcg gcaaagagaa cccggacagt gatgctgact tggatgtgga tggggatgac     1560

actctggagt atgggaagcc acaatacaca gaggctgatg tcatcccctg cacaggcgag     1620

gagcctggtg aagccaagga gagagaggca cttcggggcg cagtcctaaa tggcggccct     1680

cccagcacgc gcatcacacc tgagttctct aaatgggcca gtgatgagat gccatccacc     1740

agcaatggtg aaagcagcaa gcaggaggcc atgcagaaga cctgcaagaa cagcgacatc     1800

gagaaaatca ccgaagattc agctgtgacc acgtttgagg ctctgaaggc tcgggtcaga     1860

gaacttgaac ggcagctatc tcgtggggac cgttacaaat gcctcatctg catggactcg     1920

tactcgatgc ccctaacgtc catccagtgt tggcacgtgc actgcgagga gtgctggctg     1980

cggaccctgg gtgccaagaa gctctgccct cagtgcaaca cgatcacagc gcccggagac     2040

ctgcggagga tctacttgtg agctatctgc cccaggcagg cctcgcctcc agcagcccca     2100

cctgccccca gcctctgtga cagtgaccgt ctccctttgt acatacttgc acacaggttc     2160

cccatgtaca tacatgcaca tactcaaaca tgcgtacaca cacacacatt tacacacgca     2220

ggactctgga gccagagtag aggctgtggc ccaggcacta cctgctggct cccacctatg     2280

gtttgggggc catacctgtt ccagctctgt tcccagggtg gggcagggag gtgggggttg     2340

ggggagtagt ggggcacggc tcctaagatc cagcccccat actgacagac ggacagacag     2400

acatgcaaac accagactga agcacatgta atatagaccg tgtatgttta caatgttgtg     2460

tataaatggg acaactcctc gccctctacc tgtcccctcc ccctttggtt gtatgatttt     2520

cttctttttt aagaacccct ggaagcagcg cctccttcag ggttggctgg gagctcggcc     2580

catccacctc ttggggtacc tgcctctctc tctcctgtgg tgtcccttcc ctctcccatg     2640

tgctcggtgt tcagtggtgt atatttcttc tcccagacat ggggcacacg ccccaaggga     2700

catgatcctc tccttagtct tagctcatgg ggctctttat aaggagttgg ggggtagagg     2760

caggaaatgg gaaccgagct gaagcagagg ctgagttagg gggctagagg acagtgctcc     2820

tggccaccca gcctctgctg agaaccattc ctgggattag agctgccttt cccagggaaa     2880

aagtgtcgtc tccccgaccc tcccgtgggc cctgtggtgt gatgctgtgt ctgtatattc     2940

tatacaaagg tacttgtcct ttccctttgt aaactacatt tgacatggat taaaccagta     3000

taaacagtt                                                             3009


<210> 1540
<211> 768
<212> DNA
<213> Homo sapiens

<400> 1540
aagtagttgc tgggacagcg aaatggaggg gtgtgtgtct aacctaatgg tctgcaacct       60

ggcctacagc gggaagctgg aagagttgaa ggagagtatt ctggccgata aatccctggc      120

tactagaact gaccaggaca gcagaactgc attgcactgg gcatgctcag ctggacatac      180

agaaattgtt gaatttttgt tgcaacttgg agtgccagtg aatgataaag acgatgcagg      240

ttggtctcct cttcatattg cggcttctgc tggccgggat gagattgtaa aagcccttct      300

gggaaaaggt gctcaagtga atgctgtcaa tcaaaatggc tgtactccct tacattatgc      360

agcttcgaaa aacaggcatg agatcgctgt catgttactg gaaggcgggg ctaatccaga      420

tgctaaggac cattatgagg ctacagcaat gcaccgggca gcagccaagg acacttagcc      480

tgtgatgagg agagagtgga agaagcaaaa ctgctggtgt cccaaggagc aagtatttac      540

attgagaata aagaagaaaa gacacccctg caagtggcca aaggtggcct gggtttaata      600

ctcaagagaa tggtggaagg ttaaacagct tggatttatt cttactttgt atgttgtgtt      660

gttgtcccca gtgtcctaca aactaatgta tttgtgcaca agacatcatc tatgaatgat      720

gaagttttct caccttcaaa gtcttataaa catgttgact cttgttcc                   768


<210> 1541
<211> 2743
<212> DNA
<213> Homo sapiens

<400> 1541
gaggagagaa gaggaggtgg agaaggcttg ggctcgcgcc gctgaagtcg gcttacccgc       60

tggccgcctc ctgacaagcg ggagggatcc gcggtggacc cagggaagcg gaggagcctg      120

gcggccaccc cctcttcctc acttccctgt actctcatcg ctctcggcct ccgacacgaa      180

aaggaagcaa atgagctgat ggaagatctg tttgaaacta gacagggtct tgccatgttc      240

tggaactcat aggctcaagt aatcttcctg cctcaacctc ccaaagtgct ggaattacag      300

ttccaagatg agatgggatt ctccaacatg gaagatgatg gcccagaaga ggaggagcgt      360

gtggctgagc ctcaagctaa ctttaacacc cctcaagctc tacggtttga ggaactactg      420

gccaacctac taaatgaaca acatcagata gcgaaggaac tatttgaaca gctgaagatg      480

aagaaacctt cagccaaaca gcagaaggag gtagagaagg ttaaacccca gtgtaaggaa      540

gttcatcaga ccctgattct ggacccagca caaaggaaga gactccagca gcagatgcag      600

cagcatgttc agctcttgac acaaatccac cttcttgcca cctgcaaccc caatctcaat      660

ccggaggcca gtagcaccag gatatgtctt aaagagctgg gaacctttgc tcaaagctcc      720

atcgcccttc accatcagta caaccccaag tttcagaccc tgttccaacc ctgtaacttg      780

atgggagcta tgcagctgat tgaagacttc agcacacatg tcagcattga ctgcagccct      840

cataaaactg tcaagaagac tgccaatgaa tttccctgtt tgccaaagca agtggcttgg      900

atcctggcca caagcaaggt tttcatgtat ccagagttac ttccagtgtg ttccctgaag      960

gcaaagaatc cccaggataa gatcctcttc accaaggctg aggacaattt gttagcttta     1020

ggactgaagc attttgaagg gactgagttt cttaaccctc taatcagcaa gtaccttcta     1080

acctgcaaga ctgcccgcca actgacagtg agaatcaaga acctcaacat gaacagagct     1140

cctgacaaca tcattaaatt ttataagaag accaaacagc tgccagtcct aggaaaatgc     1200

tgtgaagaga tccagccaca tcagtggaag ccacctatag agagagaaga acaccggctc     1260

ccattctggt taaaggccag tctgccatcc atccaggaag aactgcggca catggctgat     1320

ggtgctagag aggtaggaaa tatgactgga accactgaga tcaactcaga tcaaggccta     1380

gaaaaagaca actcagagtt ggggagtgaa actcggtacc cactgctatt gcctaagggt     1440

gtagtcctga aactgaagcc agttgccgac cgtttcccca agaaggcttg gagacagaag     1500

cgttcatcag tcctgaaacc cctccttatc caacccagcc cctctctcca gcccagcttc     1560

aaccctggga aaacaccagc ccaatcaact cattcagaag cccctccgag caaaatggtg     1620

ctccggattc ctcacccaat acagccagcc actgttttac agacagttcc aggtgtccct     1680

ccactggggg tcagtggagg tgagagtttt gagtctcctg cagcactgcc tgctatgccc     1740

cctgaggcca ggacaagctt ccctctgtct gagtcccaga ctttgctctc ttctgcccct     1800

gtgcccaagg taatgatgcc ctcccctgcc tcttccatgt ttcgaaagcc atatgtgaga     1860

cggagaccct caaaaagaag gggagccagg gcctttcgct gtatcaaacc tgcccctgtt     1920

atccaccctg catctgttat cttcactgtt cctgctacca ctgtgaagat tgtgagcctt     1980

ggcggtggct gtaacatgat ccagcctgtc aatgcggctg tggcccagag tccccagact     2040

attcccatcg ccaccctctt ggttaaccct acttccttcc cctgtccatt gaaccagccc     2100

cttgtggcct cctctgtctc acccttaatt gtttctggca attctgtgaa tcttcctata     2160

ccatccaccc ctgaagataa ggcccacatg aatgtggaca ttgcttgtgc tgtggctgat     2220

ggggaaaatg cctttcaggg cctagaaccc aaattagagc cccaggaact atctcctctc     2280

tctgctactg ttttccccaa agtggaacat agcccagggc ctccaccagt cgataaacag     2340

tgccaagaag gattgtcaga gaacagtgcc tatcgctgga ccgttgtgaa aacagaggag     2400

ggaaggcaag ctctggagcc gctccctcag ggcatccagg agtctctaaa caactcttcc     2460

cctggggatt tagaggaagt tgtcaagatg gaacctgaag atgctacaga ggaaatcagt     2520

ggatttcttt gagctaggag aataagagtc tggagactgg gagccttcac ttcggcctcc     2580

gattggtggc gcatagggtg taaccaatag gaaaccccta aagggtactt aaaccccaga     2640

ttttgcaact ggggctcttg agcagcttgc tttagcctgc tcccactctg tggaatatac     2700

ttttgcttca ataaatctgt gcttttattg cttcattgtt tca                       2743


<210> 1542
<211> 2130
<212> DNA
<213> Homo sapiens

<400> 1542
cactagcaga gaagctgctg tccttccacc accagcaccg gaccacctgc tccaagacca       60

gcctcctggg gggaccaggc acccggcctt cactggcacc cagggagccg tcctcagcag      120

cgtcaacatg tcaaggccca gcagcagagc catttacttg caccggaagg agtactccca      180

gaacctcacc tcagagccca ccctcctgca gcacagggtg gagcacttga tgacatgcaa      240

gcaggggagt cagagagtcc aggggcccga ggatgccttg cagaagctgt tcgagatgga      300

tgcacagggc cgggtgtgga gccaagactt gatcctgcag gtcagggacg gctggctgca      360

gctgctggac attgagacca aggaggagct ggactcttac cgcctagaca gcatccaggc      420

catgaatgtg gcgctcaaca catgttccta caactccatc ctgtccatca ccgtgcagga      480

gccgggcctg ccaggcacta gcactctgct cttccagtgc caggaagtgg gggcagagcg      540

actgaagacc agcctgcaga aggctctgga ggaagagctg gagcaaagac ctcgacttgg      600

aggccttcag ccaggccagg acagatggag ggggcctgct atggaaaggc cgctccctat      660

ggagcaggca cgctatctgg agccggggat ccctccagaa cagccccacc agaggaccct      720

agagcacagc ctcccaccat ccccaaggcc cctgccacgc cacaccagtg cccgagaacc      780

aagtgccttt actctgcctc ctccaaggcg gtcctcttcc cccgaggacc cagagaggga      840

cgaggaagtg ctgaaccatg tcctaaggga cattgagctg ttcatgggaa agctggagaa      900

ggcccaggca aagaccagca ggaagaagaa atttgggaaa aaaaacaagg accagggagg      960

tctcacccag gcacagtaca ttgactgctt ccagaagatc aagcacagct tcaacctcct     1020

gggaaggctg gccacctggc tgaaggagac aagtgcccct gagctcgtac acatcctctt     1080

caagtccctg aacttcatcc tggccaggtg ccctgaggct ggcctagcag cccaagtgat     1140

ctcacccctc ctcaccccta aagctatcaa cctgctacag tcctgtctaa gcccacctga     1200

gagtaacctt tggatggggt tgggcccagc ctggaccact agccgggccg actggacagg     1260

cgatgagccc ctgccctacc aacccacatt ctcagatgac tggcaacttc cagagccctc     1320

cagccaagca cccttaggat accaggaccc tgtttccctt cggccctcca gccccaaacc     1380

tgcccagcca gccctgaaaa tgcaagtctt gtacgagttt gaagctagga acccacggga     1440

actgactgtg gtccagggag agaagctgga ggttctggac cacagcaagc ggtggtggct     1500

ggtgaagaat gaggcgggac ggagcggcta cattccaagc aacatcctgg agcccctaca     1560

gccggggacc cctgggaccc agggccagtc accctctcgg gttccaatgc ttcgacttag     1620

ctcgaggcct gaagaggtca cagactggct gcaggcagag aacttctcca ctgccacggt     1680

gaggacactt gggtccctga cggggagcca gctacttcgc ataagacctg gggagctaca     1740

gatgctatgt ccacaggagg ccccacgaat cctgtcccgg ctggaggctg tcagaaggat     1800

gctggggata agcccttagg caccagctta gacacctcca agaaccaggc cccgctgatg     1860

caagatggca gatctgatac ccattagagc cccgagaatt cctcttctgg atcccagttt     1920

gcagcaaacc ccacacccca gctcacacag caaaaacaat ggacaggccc agaggctgaa     1980

gcaaacagtg tcccttctgg ctgtgttgga gcctccccag taaccaccta tttattttac     2040

ctctttccca aacctggagc atttatgcct aggcttgtca agaatctgtt cagtccctct     2100

ccttctcaat aaaagcatct tcaagcttgt                                      2130


<210> 1543
<211> 1177
<212> DNA
<213> Homo sapiens

<400> 1543
cagaaactcc tccaagcaac ctaactctta acccaacttc tgacaccatg acctgctgcc       60

agaccagctt ctgtggatat cccagcttct ccatcagtgg gacctgtggc tccagctgct      120

gccagccaag ctgctgtgag accagctgct gccagccacg cagctgccag actagcttct      180

gcggatttcc cagcttctca accagtggga cctgcagctc cagttgctgc cagccaagct      240

gctgtgagac cagctgctgc cagccaagct gctgtgagac cagctgctgc cagccaagct      300

gctgccagat cagctcctgc ggaactggct gtggcattgg tggtggcatc agctatggcc      360

aggagggcag cagtggagct gtgagcaccc gtatcaggtg gtgccgccca gacagtcgtg      420

tggagggcac ctacctaccc ccctgctgtg tggtgagctg cacgccccca tcctgctgcc      480

aactgcacca tgcccaggcc tcctgctgcc gcccgtccta ctgtggacag tcctgctgcc      540

gcccagtctg ctgctgtgag cccacttgct gaaagccagt ttgcttattt tcaattgcct      600

aggtcacagt gtctctgaac tgttcatccc ttgaccacct ctggaccact aacaagttct      660

cagactttgc attgcttgtg atggagacta ctaagtatat gagctcacaa ttctatctga      720

ttccattcta caatgaatac cttgaccctt cactggggac acagaaatgc tacaaagcca      780

cctgctgatc atcaatttgc ttgggatata ctatttctga tatttctgca ggattaaaaa      840

ttactgacat gttgtggaat ttatccatga gaactatcca caagtctaat gtttccatgc      900

tttataatct attttatctt gtttacctaa aattttttgc aacatcaaag acaccaaatt      960

atagccaagt gacattcctc aagtcaccag agagaatgga agctcatcac ccaacattca     1020

gcttctaaga agtaggctgg actttccaca ttttaacatc tgatccatcc cttggttttt     1080

ggatcataat gatcttgcct gctggatatt tcagttatat ctgtgataca atgtcttctg     1140

tcatttctta ataaatatta tatactaggc aaagaaa                              1177


<210> 1544
<211> 1659
<212> DNA
<213> Homo sapiens

<400> 1544
gggtaaggcg ggagccaatc gcaccgggtt ttattgggac acgccggcaa gacgcctctt       60

cagttgtctg ctactcagag gaaggggcgg ttggtgcggc ctccattgtt cgtgttttaa      120

ggcgccatga ggggtgacag aggccgtggt cgtggtgggc gctttggttc cagaggaggc      180

ccaggaggag ggttcaggcc ctttgtacca catatcccat ttgacttcta tttgtgtgaa      240

atggcctttc cccgggtcaa gccagcacct gatgaaactt ccttcagtga ggccttgctg      300

aagaggaatc aggacctggc tcccaattct gctgaacagg catctatcct ttctctggtg      360

acaaaaataa acaatgtgat tgataatctg attgtggctc cagggacatt tgaagtgcaa      420

attgaagaag ttcgacaggt gggatcctat aaaaagggga caatgactac aggacacaat      480

gtggctgacc tggtggtgat actcaagatt ctgccaacgt tggaagctgt tgctgccctg      540

gggaacaaag tcgtggaaag cctaagagca caggatcctt ctgaagtttt aaccatgctg      600

accaacgaaa ctggctttga aatcagttct tctgatgcta cagtgaagat tctcattaca      660

acagtgccac ccaatcttcg aaaactggat ccagaactcc atttggatat caaagtattg      720

cagagtgcct tagcagccat ccgacatgcc cgctggttcg aggaaaatgc ttctcagtcc      780

acagttaaag ttctcatcag actactgaag gacttgagga ttcgttttcc tggctttgag      840

cccctcacac cctggatcct tgacctacta ggccattatg ctgtgatgaa caaccccacc      900

agacagcctt tggccctaaa cgttgcatac aggcgctgct tgcagattct ggctgcagga      960

ctgttcctgc caggttcagt gggtatcact gacccctgtg agagtggcaa ctttagagta     1020

cacacagtca tgaccctaga acagcaggac atggtctgct atacagctca gactctcgtc     1080

cgaatcctct cacatggtgg ctttaggaag atccttggcc aggagggtga tgccagctat     1140

cttgcttctg aaatatctac ctgggatgga gtgatagtaa caccttcaga aaaggcttat     1200

gagaagccac cagagaagaa ggaaggagag gaagaagagg agaatacaga agaaccacct     1260

caaggagagg aagaagaaag catggaaact caggagtgac attcccttca ctccttttcc     1320

tacccaaggg ggaagactgg agcctaagct gcctgctact gggctttaca tggtgacaga     1380

catttccgtg ggatagggaa gatagcagga agaaaagtaa actccataga agtgtcattc     1440

cactgggttt tgatattggc ttagctgcca gtctcccatt tgtgacctat gccatccatc     1500

tataatggag gataccaaca tttcttccta atattctata atctccaact cctgaaaacc     1560

cctctctcaa ctaatacttt gctgttgaaa tgttgtgaaa tgttaagtgt ctggaaattt     1620

ttttttctaa gaaaaactat taaagtactt cctagtagg                            1659


<210> 1545
<211> 6203
<212> DNA
<213> Homo sapiens

<400> 1545
ggaaaagctc ctcggagatg agcgtgaccc cctggctcgt ggtggccgcc tgttctcact       60

aacgccatgg cggggaccgg agtgagaaac cggtgtctgt cactgactgc aaagtgagcg      120

agaagcaggc tgcgggccgt cccagcacga cgtggagccc cgcggagacc tcgagatgcc      180

ccgcggggaa gctcctggcc ccgggagacg gggggctaag gacgaggccc tgggcgaaga      240

atcgggggag cggtggagcc ccgagttcca tctgcagagg aaattggcgg acagcagcca      300

cagtgaacag caagatcgaa acagagtttc tgaagaactt atcatggttg tccaagaaat      360

gaaaaaatac ttcccctcgg agagacgcaa taaaccaagc actctagatg ccctcaacta      420

tgctctccgc tgtgtccaca gcgttcaagc aaacagtgag tttttccaga ttctcagtca      480

gaatggagca cctcaggcag atgtgagcat gtacagtctt gaggagctgg ccactatcgc      540

ttcagaacac acttccaaaa acacagatac ctttgtggca gtattttcat ttctgtctgg      600

aaggttagtg cacatttctg aacaggctgc tttgatcctg aatcgtaaga aagatgtcct      660

ggcgtcttct cactttgttg acctgcttgc acctcaagac atgagggtat tctacgcgca      720

cactgccaga gctcagcttc ctttctggaa caactggacc caaagagctg cacggtatga      780

atgtgctccg gtgaaacctt ttttctgcag gatccgtgga ggtgaagaca gaaagcaaga      840

gaagtgtcac tccccattcc ggatcatccc ctatctgatt catgtacatc accctgccca      900

gccagaattg gaatcggaac cttgctgtct cactgtggtt gaaaagattc actctggtta      960

tgaagctcct cggatcccag tgaataaaag aatcttcacc accacacaca ccccagggtg     1020

tgtttttctt gaagtagatg aaaaagcagt gcctttgctg ggttacctac ctcaggacct     1080

gattggaaca tcgatcctaa gctacctgca ccctgaagat cgttctctga tggttgccat     1140

acaccaaaaa gttttgaagt atgcagggca tcctcccttt gaacattctc ccattcgatt     1200

ttgtactcaa aacggagact acatcatact ggattccagt tggtccagct ttgtgaatcc     1260

ctggagccgg aagatttctt tcatcattgg tcggcataaa gttcgaacga gcccactaaa     1320

tgaggatgtt tttgctacca aaattaaaaa gatgaacgat aatgacaaag acataacaga     1380

attacaagaa caaatttaca aacttctctt acagccagtt cacgtgagcg tgtccagcgg     1440

ctacgggagc ctggggagca gcgggtcgca ggagcagctt gtcagcatcg cctcctccag     1500

tgaggccagt gggcaccgtg tggaggagac gaaggcggag cagatgacct tgcagcaggt     1560

ctatgccagt gtgaacaaaa ttaaaaatct gggtcagcag ctctacattg agtcaatgac     1620

caaatcatca ttcaagccag tgacggggac acgcacagaa ccgaatggtg gtggtgaatg     1680

taagaccttt acttccttcc accaaacact gaaaaacaat agtgtgtaca ctgagccctg     1740

tgaggatttg aggaacgatg agcacagccc atcctatcaa cagatcaact gtatcgacag     1800

tgtcatcaga tacctgaaga gctacaacat tccagctttg aaaagaaagt gtatctcctg     1860

tacaaataca acttcttcct cctcagaaga agacaaacag aaccacaagg cagatgatgt     1920

ccaagcctta caagctggtt tgcaaatccc agccatacct aaatcagaaa tgccaacaaa     1980

tggacggtcc atagacacag gaggaggagc tccacagatc ctgtccacgg cgatgctgag     2040

cttggggtcg ggcataagcc aatgcggtta cagcagcacc attgtccatg tcccaccccc     2100

agagacagcc agggatgcta ccctcttctg tgagccctgg accctgaaca tgcagccagc     2160

ccctttgacc tcggaagaat ttaaacacgt ggggctcaca gcggctgttc tgtcagcgca     2220

cacccagaag gaagagcaga attatgttga taaattccga gaaaagatcc tgtcatcacc     2280

ctacagctcc tatcttcagc aagaaagcag gagcaaagct aaatattcat attttcaagg     2340

agattctact tccaagcaga cgcggtcggc cggctgcagg aaagggaagc acaagcggaa     2400

gaagctgccg gagccgccag acagcagcag ctcgaacacc ggctctggtc cccgcagggg     2460

agcgcatcag aacgcacagc cctgctgccc ctccgcggcc tcctctccgc acacctcgag     2520

cccgaccttc ccacctgccg ccatggtgcc cagccaggcc ccttacctcg tcccagcttt     2580

tcccctccca gccgcgacct cacccggaag agaatacgca gcccccggaa ctgcaccgga     2640

aggcctgcat gggctgccct tgtccgaggg cttgcagcct tacccagctt tcccttttcc     2700

ttacttggat acttttatga ccgttttcct gcctgacccc cctgtctgtc ctctgttgtc     2760

gccatcgttt ttgccatgtc cattcctggg ggcgacagcc tcttctgcga tatcaccctc     2820

aatgtcgtca gcaatgagtc caactctgga cccaccccct tcagtcacca gccaaaggag     2880

agaggaggaa aagtgggagg cacaaagcga ggggcacccg ttcattactt cgagaagcag     2940

ctcacccttg cagttaaact tacttcagga agagatgccc agaccctctg aatctccaga     3000

tcagatgaga aggaacacgt gcccacaaac tgagtattgt gttacaggca acaatggcag     3060

tgagagcagt cctgctacta ccggtgcact gtccacgggg tcacctccca gggagaatcc     3120

atcccatcct actgccagcg ctctgtccac aggatcgcct cccatgaaga atccatccca     3180

tcctactgcc agcgctctgt ccacaggatc gcctcccatg aagaatccat cccatcctac     3240

tgccagcaca ctgtccatgg gattgcctcc cagcaggact ccatcccatc ctactgccac     3300

tgttctgtcc acggggtcac ctcccagcga atccccatcc agaactggtt cagcagcatc     3360

aggaagcagc gacagcagta tataccttac tagtagtgtt tattcttcta aaatctccca     3420

aaatgggcag caatctcagg acgtacagaa aaaagaaaca tttcctaatg tcgccgaaga     3480

gcccatctgg agaatgatac ggcagacacc tgagcgcatt ctcatgacat accaggtacc     3540

tgagagggtt aaagaagttg tactaaaaga agacctggaa aagctagaaa gtatgaggca     3600

gcagcagccc cagttttctc atgggcaaaa ggaggagctg gctaaggtgt ataattggat     3660

tcaaagccag actgtcactc aagaaatcga cattcaagcc tgtgtcactt gtgaaaatga     3720

agattcagct gatggtgcgg ccacatcctg tggtcaggtt ctggtagaag acagctgttg     3780

agtgactgtg aggatgaacc ttcataccct ttccaagacg tgttacacag acagaccttt     3840

ttaagtcctg gacttttaaa tgaccatgaa gttatcattg aatgttaaga ttttttcttc     3900

ttgatttttt aatacacgta atctttttga agcagacatt gtatacagaa tcttacttct     3960

ctttgttcct gatatattaa aatggccagt taggctcttt ttgtagttga attgtcttct     4020

aaagagattg gatggcctct aaagaggtat gtgtatcttt atttcagatg tcacccagag     4080

taaattataa ttagaagtat agctagaatg agccccaaac cttagcctca tttattttgt     4140

tctgttacat aagtcatttt ccccttagag tgcttgaaga aatgccacct acaggttgtg     4200

tacttttcat aatggtttcc atgaatgtag tacgttcata caggcttcat tcaacctggc     4260

gttcccctcc ataattaaga tgaaacattc cggttttctc acaacacatt agcacatact     4320

gtccattagc atatctggga taaccaggtt ttgggggttg agttttggcc ttcatccttg     4380

tagatccctt tcctattgat ttcccacctt ccagtgaaat tctgaaagtc ttatcttaaa     4440

aatcgatccg cttaccatgg gcctattctt gtaagtttca gttagcattt gcatgtgtaa     4500

tattaaaatg aaagagcttc ttacccagtg ctgttgccct tttgagtatt tttgttttta     4560

aaataatgat tgtaaaatgt tttacaagta atgtaaaagc tagtatcatt cttacatact     4620

tctgtgttta aattttcatt cttaccaaaa cagttaactc tttctttcca atcaatttat     4680

acaaaagagg tcgctccagc cctaccacag gtctgactgg cactgccttt tgtttgccct     4740

tgaacagggc agtgttgtgg ggactgcaaa agagaaaacg tccaggcgag cccagttgtc     4800

ctcgcccaca gggtcctgca ggctccatca gtcaccgctt tctatggcgt ttgtagttgt     4860

gtcttttaag aagtgagtgt gattgtttac ttgataaatc agctcactct ctggtgcttt     4920

ttagagaagt ccctgattcc ttcttaaact tggaatgata gatgaaattc acacccctgc     4980

agatcagaaa aaacaaatag aagaaaatga gggttacagt aacctgttgt ctttatataa     5040

cttgcaacaa actaatttat ttttttttcc tttttttgtt tttggttttt tatggttttt     5100

taaggaaaat acttttctcc tttgaagttt tacagctttt tgtaaatgcg tcctgataat     5160

gattaggaaa atcgaccttt tcatccatga tgaccatcct catagctcag atctcctttc     5220

aaagtagtgg ctttctggat ggtaattcca tcttaaggtg tcagaactat tttcaaatgc     5280

tgcctttgac agttcttgga attttctgat attaagcagt tccatgcaaa tattcgtgtt     5340

ttataaatag ctctcatagt ctgctccatc ttgatagtta agtgatttct gaagcgtttg     5400

tgtgtgtgtt gatcaggttg tgtgatattt ttgcttgata gagaatcaaa tttgaaacaa     5460

ttaaccagcc agtagattgt ctgtcagtga ccttctgtag taataaagtt tttgccactg     5520

taaataaaaa cagtatccgt agctatcagg atcattgcgc actcatatat gctaagcctt     5580

ctgttctcta atagaagcct ttcttttcca ttgtttctgg atatttgtat tatccaaatg     5640

tgcttatttc tttgccttag cacacgtttt atggagtact tgttatacta ggtttgattt     5700

gaaactggtg cttgtcgcag aactgtcaga gcatgaggag cgctcctcct gtgggtggac     5760

gcattcacgc actcccaggt tgcacctgct gctggcggtg agcagggggt tcagcagctt     5820

gaccgatgcc ccccgagggg gctctcccca gcttaaactt tgttgtttaa atttgttaac     5880

tttttatatt aatgactatt gaaagtggta ataaaaattt atattatagg cttcaatgtt     5940

ttcatgaatg ttacccaaaa agctgtgttt tctttggtca gaggtcaaaa tttatgaaaa     6000

acaaaatgct gtatgaatgg aaatcatttt gcaattgagt gacacttcat tgtaattcac     6060

agtgtaaatt taatccaaac tgaaattttg tttcaactga atttgtaatt aactctgaat     6120

ttgtttttaa tcattagtaa tatttcagtt gggtatcttt ttaagtaaaa acaacaaata     6180

aactctgtac atgtaaaacg tga                                             6203


<210> 1546
<211> 3048
<212> DNA
<213> Homo sapiens

<400> 1546
gtaactctac ggcctagcaa ccgttgccaa ggagctcgac tctgggagcg gtctagagcc       60

cgggcgcctc ctggggggtg gggaaacggt ttcgtgagga gaatttgagg taacctcgcc      120

aactcgcggt cggaagctcc tctgaacccc gaaataggag agagctcccg tcctctctcg      180

gtcctgatgc agcacctcgc aagtggaagg ggtcgtcgcg gttaagcccc cggatagggg      240

aatcgggccc cttctgggat tcgagcggat ccaggccgct ccctggaggg atgaactgtc      300

gaggggccca gggcagcccc cgctagaggc ccggtcgggt gtggggtccc ctgtcccctg      360

tcccgagccc ggggaggggg acactatttc tggtactccc aggaggctgc gggtcgatgc      420

tcgtgccagc ctgggaccca ggcagcacgg tttctctccc aaattgtgcc agagaacacg      480

cacgtcctgg ttttcattgt tccccgcctc ctgcgactcg tttgtggtta aaattataag      540

acctaattat gagtgatcaa attaaattca ttatggacag tctcaataag gagcccttta      600

ggaagaacta taatttaatc acgtttgatt ccttggagcc aatgcaacta ttacaagttc      660

tcagtgatgt tctggctgag attgacccaa agcaacttgt ggatatcaga gaggagatgc      720

cagagcagac agccaaacga atgttgagcc ttcttggtat tcttaagtac aaaccttcag      780

gaaatgccac agatatgagt acttttcgtc agggtttggt gattggaagt aaacctgtaa      840

tttacccagt gctccactgg cttcttcaga ggactaatga actgaagaaa agagcatatt      900

tagctcgttt tttaataaaa cttgaggtac caagtgagtt tcttcaggat gaaactgtgg      960

ctgacaccaa taaacagtat gaagagttaa tggaagcctt taaaactttg cataaagaat     1020

atgagcagct caagatatct ggattttcta cagcagaaat aagaaaggat atcagtgcaa     1080

tggaagaaga aaaggatcag ctcattaaga gagttgaaca tttgaagaaa agggttgaga     1140

cagctcagaa tcatcaatgg atgcttaaaa tagcaaggca acttcgagtt gaaaaagaga     1200

gagaagaata tcttgcacaa cagaaacagg aacaaaagaa tcagctattt catgcagtgc     1260

aaagattgca aagagtacaa aaccagctga aaagcatgcg ccaagctgca gcagatgcaa     1320

agcctgaaag tttaatgaag aggctagagg aggagataaa atttaattta tatatggtaa     1380

ctgaaaaatt tcctaaagaa ttagaaaata agaaaaagga attacatttt ttacaaaaag     1440

tagtttcaga gccagctatg ggccattctg atcttcttga acttgaatct aaaataaatg     1500

aaataaacac agaaattaac cagttgattg aaaagaaaat gatgagaaat gagcccattg     1560

aaggcaaact ctcactgtat aggcaacagg catctatcat ttcccgtaaa aaagaagcca     1620

aagctgagga acttcaggag gccaaggaga agttagccag cctagagaga gaagcatcag     1680

taaagagaaa tcagacccgt gaatttgatg gtactgaagt tttaaaggga gatgagagac     1740

aggatctcac tctgtcaccc aggctggagt gcggtggtgt gatcatggct tactgcagcc     1800

tgaaactcct aggctcaagt gatcctccta cctcagcctc ctgagaagct cggactacag     1860

gcacgagcca ccatgcccag ctaattttct ttttttgttt tgttttgtag agatgtggtc     1920

tcactatgtt tcccaggctg gtcttaaact cccggcctca agcagtcctc ccacttcggc     1980

ctcctgaagt gttaggatta caggcgtgag cctgcgcctg gctgtaatta ctatacccag     2040

tttttacaga taaaggatct gagacatgca gaggttttaa gctgacttgc ctgacacccc     2100

attgctagta agtagtagaa ccaggagttg gatttagcag tctggctgta gagtcatcaa     2160

tagtttgcac atgacagaaa gctggaagaa atagtcaacc tgaaacacat gatggaatta     2220

taattcagaa tcatcttggt agataggggc actgtgctta aacaaaatgc cattaatggg     2280

attataataa atataatgtg gtagaattca agttttgttt gccaattcaa cacatcatct     2340

gttactaacg cagctttaaa aaatgcataa acgattatac tacattaatt tttttaaaaa     2400

gtatcctgtt tatggtctga ttatgcctgg agtattattt tatatttttg acttcatgtt     2460

ttaagagaca atcatgccag agtcccacat gagggtgact aaaatggaca aaaagtctgg     2520

aaactttcat atcaataatt gattatgtat taactgaaac aaaagactag agaaagacac     2580

agtgggaatt gattatgtat taactgagga ataaaagact gaagaaagac ataataaata     2640

gttaaaggat tatggaaaag atggtgttca gaaaaaaatt aacatgcagg cctgagactg     2700

ctatccctag aaaggtctgc ttgcaaagtt ggcccttggc tggcatctgg gggaacttgg     2760

ttcttggatg gattcctgcc attcactgat aagaatggct caccttgcct aaagtatatg     2820

aagagtgtgc tttatgtcga gctcctgctt gcttgcctct ttctttgtct ttctttcttt     2880

tccttcctcc cttccttcct tccttccttc cttccttcct tccttccttc cttccttcct     2940

tccttcctct ctctctctct ttctttcttt cttctttctg gaattttggt acaggctagg     3000

cagaatgtgc ctagatgatc agctcctagt aaaaaccttg agaactaa                  3048


<210> 1547
<211> 1657
<212> DNA
<213> Homo sapiens

<400> 1547
gacggaaacc agaatcgttt tgggtctggt cgccaagatg gcgtcctccg cctccgcccg       60

gactccggca gggaagcgag tgataaatca ggaagaattg cggcggttaa tgaaggagaa      120

gcagcgtctg agcaccagtc ggaaacggat agaatctcca ttcgcgaagt acaaccgttt      180

ggggcagctg agttgtgccc tgtgtaacac tccggttaag agcgagctcc tgtggcagac      240

tcacgtcctg ggaaagcagc accgagagaa agtggccgag ctgaaaggcg cgaaggaagc      300

cagccagggt tcgtccgcca gttcagcgcc tcattccgtc aagaggaaag cgccggacgc      360

agacgaccaa gatgtcaaga gagcgaaggc caccttggtg cctcaggtac agccctccac      420

atctgcgtgg accaccaact ttgacaaaat aggaaaggag ttcattagag cgactcccag      480

taagccttca ggactcagtt tactccccga ttatgaagat gaggaggagg aggaagagga      540

ggaggaagga gatggagaaa gaaaaagggg ggacgccagc aagccgctct ccgacgcaca      600

gggcaaggag cactcagttt cctcttcacg ggaggtaaca agtagtgtgc tgccaaacga      660

tttctttagt actaatcctc ccaaggcccc cataattcct cattcagggt caattgagaa      720

agcagaaata catgaaaaag tggtggaaag gagagaaaac accgcggaag cgttaccgga      780

aggttttttt gacgaccctg aggtagatgc aagagtacga aaggttgatg ctccaaaaga      840

tcagatggac aaagagtggg acgaattcca aaaagccatg aggcaggtca acactatttc      900

cgaagccata gttgccgaag aggatgagga gggacggttg gaccgccaga ttggggagat      960

cgatgagcag atagagtgtt accgacgggt ggaaaagcta cggaatcgcc aggatgaaat     1020

aaaaaataaa cttaaagaaa tcctgaccat aaaagaactg cagaaaaagg aagaagagaa     1080

tgctgacagc gatgatgagg gggaactaca ggatttgttg tctcaggatt ggagggtgaa     1140

aggggcattg ttatagggtt ttaaagaccc aaggtttcta acagcctctg ctgttgtata     1200

aaaagtgctg tctctcagta gtatagcggt tacttcatgc ctcaagattt gggtacctgg     1260

attgctaaac tggattgttg agataaaatg agccagtgag ctacagcact ttggaaaatt     1320

tgtgtaacat gtttttgagg taaagttgtt tttgaaattt ctgaagtgtt atataccaaa     1380

atgccaacat ttccacgaca gacttaactg tataatttcg ttgtaaaatc tgtaagttgt     1440

aaatattgta catagttaaa tctgtattct gttttgaatt tttttaatta atagaaagac     1500

caaccggcaa actttcagat gaatgcttac tgtggtattt ggaatgtatg tatcttctga     1560

accctacatc aagttgaaaa ggtttgtttt cttgtttctt tggtttttgt atggtttttt     1620

agaacacttc ataaacacat aagtcattgt aggttaa                              1657


<210> 1548
<211> 1971
<212> DNA
<213> Homo sapiens

<400> 1548
tccttccacc accagcaccg gaccacctgc tccaagacca gcctcctggg gggaccaggc       60

acccggcctt cactggcacc cagggagccg tcctcagcag cgtcaacatg tcaaggccca      120

gcagcagagc catttacttg caccggaagg agtactccca gaacctcacc tcagagccca      180

ccctcctgca gcacagggtg gagcacttga tgacatgcaa gcaggggagt cagagagtcc      240

aggggcccga ggatgccttg cagaagctgt tcgagatgga tgcacagggc cgggtgtgga      300

gccaagactt gatcctgcag gtcagggacg gctggctgca gctgctggac attgagacca      360

aggaggagct ggactcttac cgcctagaca gcatccaggc catgaatgtg gcgctcaaca      420

catgttccta caactccatc ctgtccatca ccgtgcagga gccgggcctg ccaggcacta      480

gcactctgct cttccagtgc caggaagtgg gggcagagcg actgaagacc agcctgcaga      540

aggctctgga ggaagagctg gagcaaagac ctcgacttgg aggccttcag ccaggccagg      600

acagatggag ggggcctgct atggaaaggc cgctccctat ggagcaggca cgctatctgg      660

agccggggat ccctccagaa cagccccacc agaggaccct agagcacagc ctcccaccat      720

ccccaaggcc cctgccacgc cacaccagtg cccgagaacc aagtgccttt actctgcctc      780

ctccaaggcg gtcctcttcc cccgaggacc cagagaggga cgaggaagtg ctgaaccatg      840

tcctaaggga cattgagctg ttcatgggaa agctggagaa ggcccaggca aagaccagca      900

ggaagaagaa atttgggaaa aaaaacaagg accagggagg tctcacccag gcacagtaca      960

ttgactgctt ccagaagatc aagcacagct tcaacctcct gggaaggctg gccacctggc     1020

tgaaggagac aagtgcccct gagctcgtac acatcctctt caagtccctg aacttcatcc     1080

tggccaggtg ccctgaggct ggcctagcag cccaagtgat ctcacccctc ctcaccccta     1140

aagctatcaa cctgctacag tcctgtctaa gcccacctga gagtaacctt tggatggggt     1200

tgggcccagc ctggaccact agccgggccg actggacagg cgatgagccc ctgccctacc     1260

aacccacatt ctcagatgac tggcaacttc cagagccctc cagccaagca cccttaggat     1320

accaggaccc tgtttccctt cggcggggaa gtcataggtt agggagcacc tcacactttc     1380

ctcaggagaa gacacacaac catgaccctc agcctgggga ccccaactcc aggccctcca     1440

gccccaaacc tgcccagcca gccctgaaaa tgcaagtctt gtacgagttt gaagctagga     1500

acccacggga actgactgtg gtccagggag agaagctgga ggttctggac cacagcaagc     1560

ggtggtggct ggtgaagaat gaggcgggac ggagcggcta cattccaagc aacatcctgg     1620

agcccctaca gccggggacc cctgggaccc agggccagtc accctctcgg gttccaatgc     1680

ttcgacttag ctcgaggcct gaagaggtca cagactggct gcaggcagag aacttctcca     1740

ctgccacggt gaggacactt gggtccctga cggggagcca gctacttcgc ataagacctg     1800

gggagctaca gatgctatgt ccacaggagg ccccacgaat cctgtcccgg ctggaggctg     1860

tcagaaggat gctggggata agcccttagg caccagctta gacacctcca agaaccaggc     1920

cccgctgatg caagatggca gatctgatac ccattagagc cccgagaatt c              1971


<210> 1549
<211> 5164
<212> DNA
<213> Homo sapiens

<400> 1549
gcatcatgga atgatataaa aatgcagctt tccaatcaca ctaagggtct ctctatttct       60

tctcttgacc accaatcagg aacctttgct ggaagcttgt ttctgattgg tgaaagtaag      120

ccataacagt ggaatgccaa ggagtaaata caaaagtgta gcaacaactg agtttgctgt      180

ctcactaccc tcagcctagg ccaacctgga ctccttcacc ccaaatgagg tgaccgctac      240

attttatatg aagacactga tttaccattc aactgtgatc catcttataa catggcaatc      300

caatacagac aggaagataa aactcaacaa cagctaaaat aaagtgtatt cccaggtaaa      360

atagacaagt gctttaattt gaaatggatt cgtccgatga gtgtcagtta caagggcaga      420

gaaggtacca gtgcagaaga gctctgactg tgggcagtgt caccaggtcc cactaagtgg      480

caacacttgt gctgggtgac ttgacccatc ttgatgtata aacccatagc cagacaggac      540

gtgcaaacag gtctcatggt gaatgcgatg ctgtggaaaa tgacatggag aatggctgtc      600

tctcagctag ggaggagggt cttggtgtcc tagtaaagaa tgttcacgtc ctggagttgg      660

tggttggtgt tctatctagg cgatgagaga aggatgcttt tcctaatgag cacctggtgg      720

gaatagagtc tctctttgca cttcgctgga ggaagaaatt tctaccactt attttttctt      780

cttgcttata gaatacacat tgcagaaaaa ggatgaagtt gaccagtgaa aagttgccca      840

agaacccctt ttatgcctct gtatctcagt atgctgctaa aaaccaaaaa tttttccagt      900

ggaaaaagga aaagactgaa tcagattaca cccatgctaa tttggtggat aaggcattgc      960

agctcttgaa ggaaagaata ctgaaaggag acactctggc atatttccta cgaggtcaac     1020

tatattttga agagggatgg tatgaagaag cattagaaca gtttgaagaa atcaaggaga     1080

aagaccatca agcaacttac cagctaggag tgatgtacta tgatgggctg gggaccactc     1140

tagacgctga gaaaggggtg gactatatga agaaaattct tgattctcca tgtcccaaag     1200

caagacactt aaaatttgca gctgcttaca acctcggaag agcttattat gaaggaaaag     1260

gtgttaaacg atcaaatgag gaagctgaaa gactgtggct tatcgcagca gacaatggaa     1320

atcccaaagc tagtgtgaag gctcaaagta tgctcgggct gtattactca accaaggagc     1380

ccaaggagtt agaaaaggca ttttactggc attccgaagc atgtggcaat gggaatctgg     1440

agtcccaggg tgcacttggg ctcatgtact tgtatggaca aggcatccgg caggatacgg     1500

aagctgccct gcagtgctta agagaagcag cagaacgcgg aaacgtctat gctcaaggga     1560

atctcgtgga gtattactat aagatgaaat tttttacaaa gtgtgttgca ttttccaaaa     1620

ggatcgctga ctatgatgag gttcacgaca tccccatgat cgcccaggtc acagactgtc     1680

tcccggagtt catcggcaga ggcatggcaa tggcatcctt ctaccacgca aggtgtcttc     1740

agcttggctt gggcatcacc agggatgaaa caaccgctaa acactattat tctaaagctt     1800

gtcgtctgaa tcccgcattg gcagatgaac ttcactcctt acttattcgt caaagaattt     1860

agaccacaat gtatttcaac aaagatcatc aatgctaaca cctcacaatg tgtgtatttt     1920

tacagtagct atgtttggtt attttgcaca tcacaaatta cactatcctg ggtattttac     1980

aggtgacatg ttacttcgtt cttgaattcg tacgctgtta agttttgcaa cttgaaacct     2040

agacacaagg tcaaattgct ggaagagtcc tcagaggtcc acctcttacc ctacagactg     2100

gccgagacca tatcaagtat taaaaccatt ctatacagca agtatcgttt atcctttctt     2160

aaacaccgag tctccaaaaa tacttagttt agctttagtt tagtaagttc agaagtagaa     2220

acaaacttat ttaaaaccat catttgaaag tttaattctt taaatttgtc tcttagtttt     2280

gtgaattttg aataataatg tttaaatttt gtttcagtca tttaaaattt aaattttcag     2340

tcatttaaaa ttttaaaaat ttaaaatttc acaaaactaa gggtaaaaga catttaaaga     2400

attaaactta aataagtgtg tgcagcattt ctacttctga agttattaaa gctaaaactg     2460

cactaagcct tttgagacat cctttattct taaaaagctc ataaataatt ggcttattac     2520

atataaactt caaaaaagtg ggttataaga cattgcttta gaatcttgcc cctccaaatc     2580

ttccctcaaa gatcttaatg agtaaaacaa ctgctacata catatgcaga atgtgtaata     2640

aaacaaaaag caattgctat atgaaaatat tcgtaagaaa agtaaagcaa attgtttctt     2700

tgtgcttcag ctcattttcc atatttttaa aaccctgtgg taaaagcctc aatgaaatca     2760

tttacaagaa ctacaattaa atattgttaa aattagcaaa aggctttccg tatatagatg     2820

acatctatga aggcaaaagg tgacagtaaa aacagtaaga tccatatgca taagattgta     2880

caaggctatt catttgtgaa acaaatatac atatcgaaga caggtctcag agatacctta     2940

actattcctt tttttataaa catattaaag gatgtggctt tattttataa atcacaacca     3000

tcccaacagt ggatttaaac aagatttctt tttagtaatg ggaaaatgca attaatatgg     3060

aggtgatagt cactaagaac tgttgaatgg cagaaaagta tttgctctcg ttttatgttc     3120

tggcttgtct gtattgcctg aacttcattt tgtctttgtg taagggaaga aatttcaaca     3180

gactcgggtt tgagatatcc tcaaatggtc atgtatttct gtctcaaatc tcttaatacc     3240

acccatgtaa cattccttca accacttgaa gatccaaatt cccaactagt attctcttct     3300

ccacacttaa tccagttcct aaagattatt attattatta ttattattat tttttttttt     3360

ttgagacgga gtctcctgac ctaatcttag cccggcgcag tggctcacgt ctgtaatccc     3420

agcactttgg gaggctgagg cgggcagatc atgaggtcag gagtttgaga ccaggctggc     3480

caacgtggtg aaaccccgtc tctactaaaa atacaaaaat tagccgggcg tgatggcgga     3540

cgcctgtagt cccagctact cgggaggctg agacagaaga actgcttgaa accaggaggc     3600

agaggttgca gtgagctgag atcgcgcaaa ttgcactcca gcctcggtga caagagcgag     3660

actccatctc aaaaaaaaat aaaaagaatc ttaaaatagg aacataataa aagatcggcc     3720

ctaagtaaag agcacttttt aaactgccat taaagatggg tttcagaaat cataaacttt     3780

gacgtgtgcc atacatggta acatgctatg cttatatgtc ttctataaat ccaatgcaga     3840

atttaaaatt tcagtttact ctagttacca taaagctaat gctctggcac aagcgagtcc     3900

ctgcaaacta ccactgctga ggacagtagt aaaccccttg acctgagact gcggtgagtc     3960

tgtaactcga gtgcattgag acttccagat cattactctt acacacacac acacacacac     4020

acatacacac acacacactc cttctctaag attccttgta gctgatatct catggaaaaa     4080

tgacatttta tcataaataa atatagagac aaaataatag tgatctttct cattcgcaat     4140

gtaaacttaa cagctacagt ttaaatgata gcatagaatt atgcctaaaa tagacatttc     4200

ccataattgt attgtgataa gttcttcagg cttgacaact tcacattgcc tctcttcctt     4260

gaatgtattt tatctggtct tttctatata gtcttttgaa ggataatttt tatcaatagc     4320

caactttggg tattttttta agtgtcaaat atcatcatgg tttgaaaaaa ggataaaaaa     4380

gctataacta aaaaaatctt aaggataaca tttggtttac taatttttaa tcatttatct     4440

ttcagaactt gtttcttatc aagaagttag caggtatgat atgtatatca tacgtatata     4500

aactggcata ggttacatcc tagggcatga ggggagtatc tttcagggat tcaaatggaa     4560

tttttacctg ttacttgttt aattgttttg ttttcaatat tcttggggat tagacagggg     4620

aaggtatttt attactgcat aatagatggt gaaacccagg aaaattaagt acttgtgcat     4680

ggccccacta tcaataacac aaagtctgta ctctggatct cccctaatgt ccctgtggtc     4740

taaacggctt gataatacaa ccgagcccct gaagtagctg ccctcctctt tccgctcccc     4800

catctcggcc ctgcccatac tccaagggtc agctcccatc tctcctccct aatgcctcac     4860

ttcaagcact aatttggctc tttctgctca ctaaaaatca tatattttac agatttattt     4920

tgtttctgga gaaggcagca aacttttact tccctgcaga agtagttaag tacatagtgt     4980

tttctctaaa aaggcatttg ataaatattt gaacagcctg tagagtttca acctctttga     5040

gatataagta tcttaaatat catagagcac tgtgattcat ttttatattt tattgctttg     5100

aatgctcaaa ctatgggaaa tctttggtaa aaataaagac aataaaatct tcacaataac     5160

ttta                                                                  5164


<210> 1550
<211> 2055
<212> DNA
<213> Homo sapiens

<400> 1550
ggttacctgg cggcgggcgg gcgcggccgg gagcggaggg ccgcggtcgc gaagaggatg       60

aagagagagt tcccgaacaa gtcggaagca gctcacaaca ccggacgccg cgcggcaggg      120

ctgtggacct ggggtggttt cgtgtcccag tcttaggaaa ctacgcgcga ggcaccgtgc      180

tgaggcgtag aggtcaccct cgggaggttt cggtgaaacc tggtgggaaa ttccgggcag      240

gcgcccggag tcgcgcccaa gtaggcagct ccgtgccgcc agacttgtgt tcgggggagt      300

tgagacgaac tgcacgggtg ggattgcatg gctctgccct cccagcgttg acaactcgcc      360

ccgaccgccc aggaagcgcg agcttactgg ctccagaagt gatgatgctg ggtggaagtc      420

gcagcatgtg aagagttgcc ggttgttatg ggattaaaaa agatgaaagg gttatcttat      480

gatgaggctt ttgctatggc taatgatccc ttggaaggct tccatgaagt aaaccttgct      540

tcacctactt ctccggacct tcttggtgtg tatgaatcag gaactcaaga gcagactacc      600

tcaccaagtg tcatctaccg gccacaccct tcagctttat cctctgtacc tatccaggca      660

aatgcattag atgtttctga acttcctaca caacccgtgt attcatcccc cagacgttta      720

aattgtgcgg aaatatctag tatcagcttt catgttacag acccagcccc ttgctctacc      780

tctggagtca cagctggatt aactaaatta actacaagaa aggacaacta taatgcagag      840

agagagtttt tacagggtgc tactataaca gaggcttgcg atggcagtga tgatattttt      900

gggttgagta ctgatagtct gtctcgttta cgaagcccat ctgttttgga agttagagaa      960

aagggctatg aacgattaaa agaagaactc gcaaaagctc agagggaact gaagttaaaa     1020

gatgaagaat gtgagaggct ttcaaaagtg cgagatcaac ttggacagga attggaagaa     1080

ctcacagcta gtctatttga ggaagctcat aaaatggtga gagaagcaaa tatcaagcag     1140

gcaacagcag aaaaacagct aaaagaagca caaggaaaaa ttgatgtact tcaagctgaa     1200

gtagctgcat tgaagacact tgtattgtcc agttctccaa catcacctac gcaggagcct     1260

ttgccaggtg gaaagacacc ttttaaaaag gggcatacaa gaaataaaag cacaagcagt     1320

gctatgagtg gcagtcatca ggacctcagt gtgatacagc caattgtaaa agactgcaaa     1380

gaggctgact tatccttgta taatgaattc cgattgtgga aggatgagcc cacaatggac     1440

aggacgtgtc ctttcttaga caaaatctac caggaagata tctttccatg tttaacattc     1500

tcaaaaagtg agttggcttc agctgttctg gaggctgtgg aaaacaatac tctaagcatt     1560

gaaccagtgg gattacaacc tatccggttt gtgaaagctt ctgcagttga atgcggagga     1620

ccaaaatcac ttctgtatgt aactttttta catacattcg atacattcag cagggactcg     1680

tgaaacagca ggatgttgat cagatgtttt gggaggttat gcagttgaga aaagagatgt     1740

cattggcaaa gctgggttat ttcaaagagg aactctgatg ctctgcgtgg gaccatgcct     1800

gaactccccg aataactgaa aaatggctga atatttttat ggttacttga tatttatttc     1860

caaggagtga gcctaagact tttttcccct tttgcaaatt gctctaagaa gtaccatgat     1920

ttcttttaaa ctgatctatg ctgtgtttgc ttattcttta gttgaacaca ctatgaagaa     1980

ttccaggtgt actagtgaat gtaatttata gttgccaaaa aaaaaaaaaa cctgaaataa     2040

ataaatgtta gattg                                                      2055


<210> 1551
<211> 6617
<212> DNA
<213> Homo sapiens

<400> 1551
actgaccccg ctgtaccacg gccctcttgc ggacagcccc ggggacgtcg ttgggacatc       60

gctgggaccc cgggctctgc agccacaacc atgtttggcc ggaagcgcag tgtctccttt      120

gggggcttcg gatggatcga caagaccatg ctggcaagtc tgaaggtcaa gaagcaggag      180

ctggccaaca gctcggatgc gaccctccca gaccggccgc tctcccctcc tctcacggca      240

cctcccacca tgaagtcgtc ggagttcttt gagatgctgg agaaaatgca ggacgactat      300

atcccatacc ccagcatcga cgaggttgtg gagaagggag gcccgtaccc tcaggtcatc      360

ctgccacagt ttgggggcta ttggatcgag gacccggaga acgtgggcac cccaacatcg      420

ctggggagca gcatctgtga ggaggaggaa gaggacaacc tcagccccaa cacatttggc      480

tacaagctcg agtgcaaggg tgaagccagg gcctaccgga ggcacttcct ggggaaggat      540

catctaaact tttactgtac cggcagcagc ctggggaact tgatcctgtc cgtcaagtgc      600

gaggaagcag aggggatcga gtacctccgg gtcatcctta ggtccaaact gaagacggta      660

catgagcgga tccccttggc tggactgagc aagcttccca gtgtccctca gattgcaaag      720

gctttctgtg atgatgcagt gggactgaga ttcaatcctg tcctgtaccc caaggcctcc      780

caaatgattg tgtcctatga tgagcatgaa gtcaacaaca cattcaaatt cggagtcatt      840

tatcaaaaag ccaggcagac cctggaggag gagctatttg ggaacaatga ggagagccca      900

gcttttaagg agttcttgga cctgctgggg gacacgatca cactgcagga tttcaaaggt      960

ttccgaggag gcctggacgt gacccacgga cagacagggg tggaatcagt gtacacaaca     1020

ttccgggaca gggagatcat gtttcacgtt tccacaaagc tgccatttac cgacggagac     1080

gcccagcagc tccagagaaa gagacacatt ggaaatgaca tcgtggccat catcttccaa     1140

gaggaaaaca cgccgtttgt cccagacatg atagcctcca atttcttaca tgcctacatc     1200

gtcgtgcagg tcgagacccc aggcacagag accccatcct acaaggtctc tgtcactgcg     1260

cgggaagatg tgcccacctt tggtccacct ctgcccagtc cccccgtttt ccagaagggc     1320

ccggaattca gggagtttct gctcaccaag ctcaccaatg ccgagaacgc ctgctgcaag     1380

tcggacaagt ttgcaaagct ggaggaccgg accagggctg ccctcctgga caaccttcac     1440

gatgagctcc acgcccacac acaggccatg ctgggactgg gcccagagga ggacaagttt     1500

gagaatggag gccacggggg gttcctggag tcttttaaga gggccatccg cgtacgcagc     1560

cactccatgg agaccatggt gggcggccag aagaagtcgc acagtggggg catccctggc     1620

agcctcagcg ggggcatctc ccacaacagc atggaggtca ccaagaccac cttctcgcct     1680

ccagtggtgg cggcaacggt gaagaaccag tcacggagtc ccatcaagcg acgctcgggg     1740

ctcttccccc gcctgcacac gggctcagaa ggccagggcg acagccgggc acgatgtgac     1800

agcacatcca gcacacccaa gaccccagat ggtggacact cctctcagga gataaagtct     1860

gagacctcat ccaatcccag ctctccggaa atctgcccca acaaggagaa gcccttcatg     1920

aagttgaagg aaaacggccg tgccatctcc cgctcctcct ccagcaccag cagcgtcagc     1980

agcactgcag gggagggcga ggccatggag gagggcgaca gtgggggcag ccagccgtcc     2040

acgacctcac ccttcaagca ggaggtgttt gtctacagcc cgtccccgag cagcgagagc     2100

cccagcctgg gggcagctgc caccccgatc atcatgagcc ggagtcccac agatgccaaa     2160

agcagaaact ccccgagatc gaacctgaaa ttccgctttg acaagctcag ccatgccagc     2220

tctggtgcgg gtcactaatg tgaaagtgga gtccttcgcc tgtccaaggg aatcccctct     2280

tctgtcctgg aaaaggctcc tgtaccagca gtttgggagt gccgtccacg accctgacag     2340

tcccagccct gctgccccat ggccacgtgc ccacagatgt gctgttggtc caggtgtccc     2400

agtctggcca cagccctgcc tccgccctca cctacatgcc ctcccagccc ctcccatctc     2460

tggacgaggc ctccttcctc aggttcctcc tgctcctgac ctcccagtgt gatgtccggg     2520

tcctttatca tcctattcat cctggagagg aaaagtgtcg ggcaaagggg gatctggggg     2580

gagctcagca gtgactgggg agctggtctg cctcagagac agagtagggg gtgggagcag     2640

agcctcggtg agggtcttgg ccacagggca gtgccttcct gaacgtggca ggctttacta     2700

ccaggaacgc actcggtggt ggaggcccca tgttcccagg agccaagatt cgtagcatcc     2760

ttgaggccat cctgataaaa ttcggcgcta ttgcccccgt agctctggag ctctaaaccg     2820

tctatctgct tctgtgctga acgcctttcc catctgctga cgtaggccca gggctgccct     2880

gcccctgctg ccagtgtacc gtgagcgggg ctccagccag ttcaagctca gagccagagc     2940

tggacgggcc agaactgcgc tgcacacttc ctggactgag gcggggactt tgggtcccac     3000

ccggtttctc ctgattatgg ctgctgtggg gtgaggggag ggaggggcag ccccgaggca     3060

gtctcttccc tttgagaaga tattttccca caaaggggtg ggaagccagg agtgagaagg     3120

aattcaggga gagcaaagga gccagtgctg agatgctgct gtgttggttg aggaaaacct     3180

cgggcctgag ggccaggccg gagcccaggt ctctgctgac aatgggggtt caaggaagac     3240

gtcgttatct cccctcccca cttactcgag gagagaggtg agggggggat gacttgcggg     3300

ttctgatcag gcccctgggt ggggaagggg cacagtgtcc ctcagcagct tacgcccctg     3360

gagtcttggg gggcccagcc tggccctggg gccttttcca gctactgtgc ccttgggcag     3420

ctgcgtctgg ggctcaaccc cccaatcctg ttcccctctc cagctgcggg tctgtaggca     3480

gctgtcacat ctgaagggtt tctgcaacct ggaccccatc tgggtgtggg tcagaccctg     3540

tgacccacat gccaccccca ccctccacag agcccccttg ctgggacagc cagctcacct     3600

ccaaggacat cccctcctgg cttctccccc ttccgagtct gcagcgccgt gggcttctct     3660

gccgatgggc ccgggttggg gttaaggtgg gcatcctcca ggtacaacga gcctgaagag     3720

cccctttcag tgcagacggg gctgcagagt gacactggct gggcacctgc cccacgacca     3780

atgacaagga tttccagctg aatgctttat tcccataggg atctggacct gtgcccaaga     3840

tataaatact acactttttt tttttttttt taactgacat tgtgaaattc tccctatagc     3900

ttttgccatt caagcaacat tgtgatcttt cttccccgcc acgtgtgtgg gaatgattga     3960

gtcctgtttg caagctggag aggagctctc cctttgctag tactttctct aaagtactag     4020

tctagtaaaa tttattcttg ttagaaggtc aacaaaatat ctgtttagct tttatgaaga     4080

gtcaccgtag cagcccccac ggctggaaag aggcctgtac gttctggacg cgttttgttg     4140

gctgggcttc tggaggcact ggcaaggtca aactgcattt ctttaagaac agttgcagga     4200

tctggctcgc ctctgtggga agccggcatt acaggtgctt ggtggatggg ccgtgtcaca     4260

ttgccatctg gggtcctttg gggtttccag gttgtcacca tgctgtccca tttgggaatc     4320

ccatacctgc ctgtccccac tgcgctggct gacccttgct gcctgctgcc tcttgggagg     4380

gctttgtccc tgcctctgag ctggtgggca ggatggctgg gtggccccca gagaagcaca     4440

gacctgagat ggggtctcca tgcccggttt gctgttggaa tgatctgaac aggaccccaa     4500

atgcctcttc cctctggtca tgcctcacta tctctaggag ctccatcctg tggcttccag     4560

agtgtgcact tccagcccac ccgggcagtg ctgagaggga ggaggagaac aaggatggcc     4620

cagcctcccc tccctcccct agaccacggg gcgggcagct cgggttcctg gagggctgtt     4680

tcccccacgc tgtccctaca tctgctctga tctaaaatgt ctttcctttt atgctgcgcc     4740

cagtcttggg gctcaaagat ttgcccaaac ctcattggcc ctcgtgacta ggctcatcta     4800

gatggtgctc acgctggtgt ttgaggcatt tccactgtga tctccacgag gggatgtttt     4860

ccgggacaca tctctggctc tgggaactgc ctgactcact gaagaaacta cttttcaggc     4920

actgtagggt cacccatatg cctccagctc agttgacgct taaaaacagg tgcagaaaag     4980

ctcgcgatgg aaggtcttaa tgagagtgtc tgtctatgcc aatcatgtaa aatgacgttt     5040

cttgaaaaag attcagtggt tcagctttgt cagcatcatc tcaacacaag cctgctggct     5100

ctttttagca tctcatccaa ccatgtcatc gtccagatga gaaatcttag cccaggtgag     5160

gggagtaact tgcttgaggt cacacagctg gctgttggca aagctgggat tagaaccctc     5220

aacccagggt cccttcctct gcagcgccta catggttggt tgaataagtg gctgcgtttc     5280

ctggggccct gggttttggg gaagccagtt agctgctgct ttggcactgg catggaggtg     5340

agcagtcaag gatgctggtg aggctgcagt ttctgctctt tttcatcagg ggggatagtc     5400

tctaggattt ttcagtgagg acccttgggc tttggatgca gcttgaacca agaaaacgag     5460

gagggaaagg gattcagtga actattcctc agtgggatcg gttcttcagc tcctgatggg     5520

ggctgtgtaa tgggggcaga ggccagggaa aaagatgctg ttcacccacc ctcagcttcc     5580

cttttcctaa attaagagga aaagtggtca aagaaaaact cttcatttct ccctgattct     5640

taaacgaagg tggttaatag aaactcaggc tcccgtgaca aggcaggaca agagcctgtt     5700

tcgctttcct ccctgaccct gccaggtgcc aactcaaaca ctacctttct cattggtttc     5760

taagtcagta gagacagatc tgttttaagc agttgggggt tcgagtagat ctcatgggta     5820

caggaggcca gcagggacca ggccagtcag ccatgctcag gacccctcgg ctcctccccc     5880

agcctctagc taccctgtat cgaggcaagg ggaggccagt aaagtttgcc aagcctgatc     5940

ctgcagcctg gtggggctgg ctggggtatt cttttaccaa actctgtttt accgccagcc     6000

ccttgtacac cccaatccca tgtctccctc ccttcagctg gaccgtgtgc ccctttggga     6060

ggaagaagac aagccccact agggccaagg gcagcagagc cctgccgagt gagaggctgt     6120

ggggcagcgg ctctgtcctg tgccttacca gccctgggga ggggggcatt tggctggaag     6180

actggaattt aattgccatc gtctttgatt ttgtgacatt tctgcttgga agtgtgaact     6240

accccccccc ccccgcttcc tgctccttag catgcgtgca gctctctcct gttttgggtg     6300

ttccccttgg acactccagc tcggggactg ctggcgtgtg aatgtgcaga ttcccctgtg     6360

tggtcgaacc taagaactgt ggcttggaag tgatgctcca tgtgacgacg actttgcttt     6420

ctttcctctt agtgaggagg tgattcgtag atcccaactg cctatgtaat gtaaataatg     6480

tacatttaat ttattgctat ggtagcacat tgtatttgtt aatgtacaaa acaaattcta     6540

aaaggttgac aaatgtatat tttgttgctt aaatgtgtct ttgcagaaat tgacaataaa     6600

taacatattt tgtgtcc                                                    6617


<210> 1552
<211> 2313
<212> DNA
<213> Homo sapiens

<400> 1552
attcatcccc agcgcagagc agcgctggca gccggcgccg cgatggagga agagctgaag       60

tgtcccgtgt gcggctctct gtttcgggag cctatcatcc tgccctgttc ccacaatgtc      120

tgcctgcctt gcgctcgcac catcgcggtg cagaccccgg acggtgagca gcacctgccc      180

cagccgctcc tgctttcccg gggatcgggg ctgcaggcgg gcgccgccgc cgctgcctct      240

ctggagcacg acgctgcggc tggcccggcc tgcggcggtg caggcgggag tgcagctggc      300

ggcctcggcg gcggtgcggg aggtggcgga gaccacgcgg acaagctcag cttgtacagc      360

gagacagaca gcggctacgg gtcctacacc ccgagcctca agtcccccaa cggggttcgc      420

gtgctgccca tggtgcccgc accacccggc tcctcggctg cggcggctcg gggtgccgcc      480

tgctcctcgc tgtcctcgtc ttcgagctcc atcacgtgcc cgcagtgcca ccgcagcgca      540

tccctggacc accgcggcct gcgcggcttc cagcgcaacc ggctgctcga ggccatcgtg      600

cagcggtacc agcagggccg cggggccgtg ccggggacgt ctgcagccgc ggcggtggcc      660

atctgccagc tgtgcgaccg caccccgcca gagccagcag ccacgctctg cgagcagtgc      720

gacgtcctct actgctctgc ctgccagctc aagtgccatc catcccgggg acccttcgcc      780

aagcatcgcc tggtgcagcc gccgccgccg ccgccgccgc ccgccgaggc agcctccggg      840

cccactggca ccgcccaggg cgcccccagc ggaggcggcg gctgcaagag cccgggaggc      900

gcgggggcgg gggcgactgg gggcagcacg gcccgcaagt tccccacgtg tcccgagcat      960

gaaatggaga actacagcat gtactgcgtg agctgtcgaa ccccggtgtg ttatctgtgc     1020

ctggaggagg gccggcacgc caagcacgag gtgaagccgc tgggggccat gtggaagcag     1080

cacaaggcac aactatctca ggccttaaat ggagtttcag ataaggcaaa ggaagcaaag     1140

gagtttctgg ttcagctaaa gaacatattg cagcagatcc aggaaaacgg actggactac     1200

gaagcctgcc tcgttgctca gtgtgatgcc cttgtggatg ctttaactcg tcagaaagcc     1260

aagctgctca ccaaggtgac taaagagagg gaacacaagt tgaagatggt ttgggaccag     1320

atcaatcact gcacattgaa gctgcgtcag tccaccggac tgatggagta ctgcctggag     1380

gtgatcaagg agaacgaccc ctccgggttc ttacagatct cagatgctct gatcaagcgc     1440

gtccaggtgt ctcaggagca gtgggtcaaa ggcgccctgg agccgaaagt gtctgcggag     1500

tttgatctga ctttggacag cgagccgctg ctgcaggcca tccaccagct ggacttcatt     1560

cagatgaaat gtagggtgcc acccgtcccc ctactgcagc tggagaaatg ctgcacccgt     1620

aacaacagcg tcacgctggc ctggaggatg ccacccttca cccacagccc cgtggacggc     1680

tacatcctgg agctggacga cggtgccggg ggacagttcc gggaagtgta cgtcggtaag     1740

gagactttgt gtaccatcga cggtcttcac ttcaacagca cctacaacgc ccgagtcaaa     1800

gctttcaact cttctggtgt cgggccttac agtaaaactg tcgtcctgca gacatccgat     1860

gtggcctggt tcacatttga ccccaactct gggcatcggg acatcatttt atccaatgac     1920

aaccagacag ccacctgcag cagctatgac gaccgggtgg tgctgggcac agctgcgttc     1980

tccaagggcg tgcactactg ggagctgcac gtggaccggt acgacaacca cccagacccc     2040

gccttcgggg tggccagggc cagcgtggtc aaggacatga tgctgggcaa ggatgacaag     2100

gcctgggcca tgtatgtgga caacaaccgc agctggttca tgcactgcaa ctcccacacc     2160

aacaggacgg aaggtggcgt gtgcaagggg gccaccgtgg gcgtgctgct ggacctgaat     2220

aagcacactc tcaccttctt catcaacggg cagcagcagg gccccacagc cttcagccac     2280

gaggttcagc cctcggttac ttccctcttt taa                                  2313


<210> 1553
<211> 3936
<212> DNA
<213> Homo sapiens

<400> 1553
atggaggaag agctgaagtg tcccgtgtgc ggctctctgt ttcgggagcc tatcatcctg       60

ccctgttccc acaatgtctg cctgccttgc gctcgcacca tcgcggtgca gaccccggac      120

ggtgagcagc acctgcccca gccgctcctg ctttcccggg gatcggggct gcaggcgggc      180

gccgccgccg ctgcctctct ggagcacgac gctgcggctg gcccggcctg cggcggtgca      240

ggcgggagtg cagctggcgg cctcggcggc ggtgcgggag gtggcggaga ccacgcggac      300

aagctcagct tgtacagcga gacagacagc ggctacgggt cctacacccc gagcctcaag      360

tcccccaacg gggttcgcgt gctgcccatg gtgcccgcac cacccggctc ctcggctgcg      420

gcggctcggg gtgccgcctg ctcctcgctg tcctcgtctt cgagctccat cacgtgcccg      480

cagtgccacc gcagcgcatc cctggaccac cgcggcctgc gcggcttcca gcgcaaccgg      540

ctgctcgagg ccatcgtgca gcggtaccag cagggccgcg gggccgtgcc ggggacgtct      600

gcagccgcgg cggtggccat ctgccagctg tgcgaccgca ccccgccaga gccagcagcc      660

acgctctgcg agcagtgcga cgtcctctac tgctctgcct gccagctcaa gtgccatcca      720

tcccggggac ccttcgccaa gcatcgcctg gtgcagccgc cgccgccgcc gccgccgccc      780

gccgaggcag cctccgggcc cactggcacc gcccagggcg cccccagcgg aggcggcggc      840

tgcaagagcc cgggaggcgc gggggcgggg gcgactgggg gcagcacggc ccgcaagttc      900

cccacgtgtc ccgagcatga aatggagaac tacagcatgt actgcgtgag ctgtcgaacc      960

ccggtgtgtt atctgtgcct ggaggagggc cggcacgcca agcacgaggt gaagccgctg     1020

ggggccatgt ggaagcagca caaggcacaa ctatctcagg ccttaaatgg agtttcagat     1080

aaggcaaagg aagcaaagga gtttctggtt cagctaaaga acatattgca gcagatccag     1140

gaaaacggac tggactacga agcctgcctc gttgctcagt gtgatgccct tgtggatgct     1200

ttaactcgtc agaaagccaa gctgctcacc aaggtgacta aagagaggga acacaagttg     1260

aagatggttt gggaccagat caatcactgc acattgaagc tgcgtcagtc caccggactg     1320

atggagtact gcctggaggt gatcaaggag aacgacccct ccgggttctt acagatctca     1380

gatgctctga tcaagcgcgt ccaggtgtct caggagcagt gggtcaaagg cgccctggag     1440

ccgaaagtgt ctgcggagtt tgatctgact ttggacagcg agccgctgct gcaggccatc     1500

caccagctgg acttcattca gatgaaatgt agggtgccac ccgtccccct actgcagctg     1560

gagaaatgct gcacccgtaa caacagcgtc acgctggcct ggaggatgcc acccttcacc     1620

cacagccccg tggacggcta catcctggag ctggacgacg gtgccggggg acagttccgg     1680

gaagtgtacg tcggtaagga gactttgtgt accatcgacg gtcttcactt caacagcacc     1740

tacaacgccc gagtcaaagc tttcaactct tctggtgtcg ggccttacag taaaactgtc     1800

gtcctgcaga catccgatgt ggcctggttc acatttgacc ccaactctgg gcatcgggac     1860

atcattttat ccaatgacaa ccagacagcc acctgcagca gctatgacga ccgggtggtg     1920

ctgggcacag ctgcgttctc caagggcgtg cactactggg agctgcacgt ggaccggtac     1980

gacaaccacc cagaccccgc cttcggggtg gccagggcca gcgtggtcaa ggacatgatg     2040

ctgggcaagg atgacaaggc ctgggccatg tatgtggaca acaaccgcag ctggttcatg     2100

cactgcaact cccacaccaa caggacggaa ggtggcgtgt gcaagggggc caccgtgggc     2160

gtgctgctgg acctgaataa gcacactctc accttcttca tcaacgggca gcagcagggc     2220

cccacagcct tcagccacgt ggacggggtc ttcatgccag ccctcagcct caaccgcaac     2280

gtgcaggtca ccctgcacac aggattggaa gtgccgacta acctggggcg gccaaagctg     2340

tcaggcaatt agccccgctc cagctcggca ctgtgcctgt gacagtgaca ttcacaggca     2400

aaacgcccac cattctcact aagctcaaat aacccacaaa agcaggatat gcaaatcatg     2460

ggtgcaacct ggcagcgtgg agtgtcatag aaacacattt tcttggggac gcagggaatg     2520

ggtccacggg ccatgctcac agctgccact gtcagtggca aaggaaggta cgtgtgtcac     2580

ccttattcca cccagacatt acgaacactc cccaagaagg acctttctca agggagtcag     2640

cattcgggct tcatgtctat gtttcctgcc atctgttttc aaagcttgtc tttttttgga     2700

gggagaggaa ggtagacttt gagactggcc tcctgagagc ggcagtcagg agctgcgctg     2760

taatcccacg ccccgggtgt tggccctccg tggggacctt gcctcctcag agtcccgaga     2820

ttgcagattc tcatcatgct gagaaagtta tcttttagct tcttggtcct agagtcttta     2880

gtagcacctg ccacttgcag acccaatgca ggattgatag aaagggacat taatcattca     2940

tgcttgactt ttgcctctct cactgaagtg ttagaacctt ttaaaatggc ttcctttatt     3000

aatcagccaa ttgtgttctc tctctctctt cctccatcct tcatttcttc tccctccctc     3060

cttctctttc tctcttcttc tctctctcct tccttccctc ctttgctctc tctttcttcc     3120

tttcctcctt ctctcttact ttcctccatc cctgcctctt tcttccctct ttcgctctct     3180

ttccctccct ccttctctct ctctctcaca cacacacagg catgacagtc tcctaaaatt     3240

aattcactca gttcttagtt cttaaatcca cgtgaaaaca caagaatttt aacaactatg     3300

tcataggtct tcgcctggtg atggctcctt tctgaaactg gcagcccaag aagttaactg     3360

aaaatgcatc cagattgctc ttctgagctg aaccactctc agactcataa gcatttaaaa     3420

tgggagaccc tgggaaagcc tgttctagtc agtccaccct attgtcatta tgaaagcatc     3480

atgaacacaa gtggcccctg tggcaggccg ggacggctct gccctgatgc agtgggcggg     3540

atctctgggg aaggcaggaa atagaagggc agtatcaggt accttgtctc ccagcttccc     3600

actgtgagac tgggtgtgcc gagtctgacc tgccagggca ggactctgga aacaccaggc     3660

ttctcccttg agatccacat tgattcatcc acacctctca gagacagctc atggcagggg     3720

ttttgagcct gccaggctct tgttcccagg gaacccttcc tctcctccct cctctcatct     3780

tcccagtcac ctgccacctc cagctccacc tggtagtaac atttctctct ccttttaaaa     3840

agaatatatt ttgtcaagca ttttatttct gaggctgaga agtgacttgt caatttgctg     3900

gactggattt ttataaaatt cgcccattca ccagca                               3936


<210> 1554
<211> 4399
<212> DNA
<213> Homo sapiens

<400> 1554
ctgctagaaa tgcaaataac agaaggtgga gggggtaggg aacatgcctt ccagattatt       60

cctgtgggta ctgatctgct agctaaattg agatgtactt tatcaggcta aatggctttt      120

ctctccccga tcttttattg tttgtgatgg agttgtcaaa tatttgcatg caatataaat      180

acaattttta ggcagcgttg tgatatggat ggtgcctgta tttaccagct cagcactgcc      240

agtgaaagat gtagaagata aacctgaaca acaaaccaga acaagagaga ctgacaaatc      300

acccaccagt actgagcctc gacagcaacc aagtgcctta tttgctagag gaaacaggaa      360

agcggtcaaa agtccccaaa gatcatcgag taaaataaaa gaaaacaagc atccatttgc      420

tctttatggc tggggagaaa aacagaccga tacaggaagc cagaagactc acaacgtctg      480

tgcgtccgct cctgtgcacg agattcatga atcagcatta cgagccaaga acagaagaca      540

ggtggaaaaa aggaaactgg ttgctcaaag gcagcgagct cactctgtgg atgtggagaa      600

gaacagaaag atgaaggctt cctcctcaga gaacccgtgg atgacagaat acatgaggtg      660

ctattcggca agagcttaaa gaaacacttg cgtggacagc ctcttttaaa aagtgtaaat      720

gactgaaagg aaaaacaaaa caaaaaccat caaaagaaac ggacacaggt ttaagaaacc      780

aactgattat gcaaggtttt ttttagggaa tttgtaaaag attgttttat tttgatgaat      840

attggtcacc tacctcggca gtagggcaga cagttgaagc catagacatt tggttattta      900

tgaagataat tccctaaatc tttgatattc ttataaggtt tttgttttaa agcatcttaa      960

tcttttaaga tactgacacc aaatgccttt aaatggcaac agatgcttac agttcagtat     1020

tcttttcata agcttaggta gagcctatta tcatcttgtt ctaaataact ttccagattc     1080

catagctata agatcattcc atcctacagc ataagactcg ttttccttat atgccgtttt     1140

gtttgtgaaa gaatatcaag tcaaaaatga gtgtcagcac tactactgat tccatgtata     1200

atgaaagtag aactttgcta gttcctgaaa atttttaact tatttgtatt tcagttcagc     1260

agcatcttta tgtagattgt gatatttaag aattatctgg gctgggcgag ggtctctttt     1320

tctctttcag tgatcatcta ggcagttatt atttaatagt ttaatagctc aagtacattc     1380

caatagacga agtgcacaca acacaatatg tgtgtacagt agtagtaaag tttcttttga     1440

gtagtcaaag actcactttt tttattgcct tttttttttt ttttaaagaa tacatactgt     1500

ggattcagtc ccttgtcaca cttgaccttt tggcatacac ccactgtgga cttttgcctc     1560

ttctgtaatg gctggcaatg acatttcaaa cttacaatct ggaattgcac ttggtacatt     1620

ggcattgctt gttccactgg gatggggacc agtgtgaaga tgcctgttag atagactgcc     1680

cacccctact ttctcttttt ctttatagca cttaacaata acaaagtctt gatgatgtac     1740

agtattcaaa ctttaggttg aaatacgtta ctctttgatt cctagccagt agatcttatc     1800

tacactttaa tgggagagaa tggtggtgtg tgggtaggca caaatttatg taaatagtgc     1860

tccttctctt tagtatgttt gctttggggg tagaaaaatg gttttaacaa acactggttt     1920

ccatcaaatg aatgatgtct tctccatcct gtggagacaa gaatctgcta gaaggatatg     1980

tgctaagttc cttataagag ataatggtgc tctgcctatg ccagcttggc acccgaagat     2040

gtgtgagtgg acgtgaggct gagtattacc ttagtatttt tctctgggtc tttggaaaac     2100

catagtcaat ttttagaaca tattgctttc attccccata aactcttcac acatgataac     2160

tgtttaagct ttgaaaacac atactgaagt attgtgagct taaaaaaact ttttaaatat     2220

ttgcatagtt ttgaggtgaa tttgtttcct tacagatctc tcctaatcat tgagatgtat     2280

atttcaaaag aggaaatttt acatgttgtc caaaacagcc ttgctagtaa ctggtgaatt     2340

ttggtattaa ctattattaa agtctttaaa cgacacaggt acctaaagat caccttaatg     2400

tggcaatttg tgatggtgta gctagctgat tgtgaaaact gttcctttaa agtcgcttct     2460

tgcatgttcg gtgttagtca tccagctcag gcttgtgttg cagctgacaa tctaggaaag     2520

acggccttag agagtggtgc aggccccaca ctgacggact gccttagaaa cccgacttcc     2580

tctagacttt gaaccgccag acttttctct tgtttagaaa acaaacttat atttaatgta     2640

cttactactt aaaactccag acagagatat aatgtagaag gcaaatattg gccaattttt     2700

tcctcttttt aagtggaaga caaatgaacg ggatttttaa agtgctttta aagtgcatga     2760

atggttaata aatcagtatg aattgtaagc cttcatctta catccaagtc cttagttggt     2820

tagggtttct tttctttctt ttttaaagag tgtcaattac cttttgaacc tgtgaaaatt     2880

tgatagttgt taacagtctg atggtcctaa ttctttcttt tcattctaga aatgaatgtg     2940

gttgtaatca tgttcctaat tcttgggaca acctgcaaga cagtgagaca gtttaaaaat     3000

tacctttcat gttgaaaaag tctgaaacag agaacccaat gatatttaaa ataaatgcta     3060

cataaaactc tttttaaaat tttgatttta acttaattaa aacaatgtca taaatatgct     3120

ttttgatttt gttactgctt ttaatattaa agtaatagaa tattgaagca atattgtcta     3180

gcactctgct ggacattaag tccgcgggag gagaagtgaa caggaatcga ttctttgtct     3240

tttaactgcc cttagttagg agatgttaaa atacttggca cctctggtta tatgtatgtt     3300

atgtgtgttc tcccccctaa aatttctaag cacatttatt cacttttaaa atgaatcttt     3360

aaaagattat agttagtagt tatagttaat attctattta cttggaaaaa tgtgaataaa     3420

tggatcttca aaagattcat tttaaaaatg aataaatgta taataggcta taggtgatct     3480

tacttgcgta ttaggtagga ggcacatatt tataccattt catatgtaat atctttgtca     3540

ttgtgtttca tcgaagatca attgctagca acttgaaggg tatttatact tgggtcactt     3600

gaactcagct gactaaattg taagaacgag agcaagcaag atggctgtta ttggaagcca     3660

taacttccag aagataattc tgcacaattc gtaagttaaa aaaaatctgt agggtcttcc     3720

actatccttt ttcaggttga taatgctgtt ctgggcacac actttgtaaa tggaatgtta     3780

tggtacagtc gcctctcagt atccatgggg cattggttcc aggcctccct taggatgcca     3840

aactccatgg atactcaaac cccttctata aaatggtgta gtatttgcat atatcctaga     3900

cacatcctcc tgtatgcttt aaatcatctc tagattactt aaaataccta atacaatgta     3960

aatgctctgt aaatagttgt tatactatat tgtttaggga ataatgacaa ggaaaaaaaa     4020

gcctgtacat gttcagcaca agtgaaacca tcctttttgc ccccaaatat tttcaatttg     4080

tatttggttg aatccatgga tgcagaactc acggatacag agggccgact gtactttctt     4140

taaagtgttc aaaagtatta ctagcaaaga ggaggaggag caaagcatat atcagaagta     4200

aaacaatttt tcttgttgac tgctttggta aaaaacagtt tgatggatag ttttacattt     4260

cactggacta gataaaaaat ggtgctaata tttatgtagc ttgatgctat agttgctttg     4320

gtatcaaact taatacctaa cccatataag atccttatta tataattttg tgatcagtaa     4380

aatgatattt taaagagtg                                                  4399


<210> 1555
<211> 5089
<212> DNA
<213> Homo sapiens

<400> 1555
gtaggctgcg ggcagcgagg agcggctggc gctcgaggcg gcggacggca ccatgtcccc       60

ggggagcggg gtgaagagcg agtacatgaa gcgctaccag gagccgcgct gggaggagta      120

cgggccgtgc taccgcgagc tgctgcacta ccgcctaggc cgccggctgc tggagcaggc      180

gcacgcgccc tggctctggg acgactgggg cccggccggc tcctcggagg actcggcgtc      240

gtcagagtcg tcgggcgccg ggggccccgc accccggtgc gccccgccct cgcccccgcc      300

gcccgtagag ccggcgaccc aggaggaggc ggaacggcgg gcgcgcgggg ccccggagga      360

gcaggacgcg gaggccgggg acgcggaggc cgaggacgcg gaggacgcgg ctctgccagc      420

actgccagtg aaagatgtag aagataaacc tgaacaacaa accagaacaa gagagactga      480

caaatcaccc accagtactg agcctcgaca gcaaccaagt gccttatttg ctagaggaaa      540

caggaaagcg gtcaaaagtc cccaaagatc atcgagtaaa ataaaagaaa acaagcatcc      600

atttgctctt tatggctggg gagaaaaaca gaccgataca ggaagccaga agactcacaa      660

cgtctgtgcg tccgctcctg tgcacgagat tcatgaatca gcattacgag ccaagaacag      720

aagacaggtg gaaaaaagga aactggttgc tcaaaggcag cgagctcact ctgtggatgt      780

ggagaagaac agaaagatga aggcttcctc ctcagagaac ccgtggatga cagaatacat      840

gaggtgctat tcggcaagag cttaaagaaa cacttgcgtg gacagcctct tttaaaaagt      900

gtaaatgact gaaaggaaaa acaaaacaaa aaccatcaaa agaaacggac acaggtttaa      960

gaaaccaact gattatgcaa ggtttttttt agggaatttg taaaagattg ttttattttg     1020

atgaatattg gtcacctacc tcggcagtag ggcagacagt tgaagccata gacatttggt     1080

tatttatgaa gataattccc taaatctttg atattcttat aaggtttttg ttttaaagca     1140

tcttaatctt ttaagatact gacaccaaat gcctttaaat ggcaacagat gcttacagtt     1200

cagtattctt ttcataagct taggtagagc ctattatcat cttgttctaa ataactttcc     1260

agattccata gctataagat cattccatcc tacagcataa gactcgtttt ccttatatgc     1320

cgttttgttt gtgaaagaat atcaagtcaa aaatgagtgt cagcactact actgattcca     1380

tgtataatga aagtagaact ttgctagttc ctgaaaattt ttaacttatt tgtatttcag     1440

ttcagcagca tctttatgta gattgtgata tttaagaatt atctgggctg ggcgagggtc     1500

tctttttctc tttcagtgat catctaggca gttattattt aatagtttaa tagctcaagt     1560

acattccaat agacgaagtg cacacaacac aatatgtgtg tacagtagta gtaaagtttc     1620

ttttgagtag tcaaagactc acttttttta ttgccttttt tttttttttt aaagaataca     1680

tactgtggat tcagtccctt gtcacacttg accttttggc atacacccac tgtggacttt     1740

tgcctcttct gtaatggctg gcaatgacat ttcaaactta caatctggaa ttgcacttgg     1800

tacattggca ttgcttgttc cactgggatg gggaccagtg tgaagatgcc tgttagatag     1860

actgcccacc cctactttct ctttttcttt atagcactta acaataacaa agtcttgatg     1920

atgtacagta ttcaaacttt aggttgaaat acgttactct ttgattccta gccagtagat     1980

cttatctaca ctttaatggg agagaatggt ggtgtgtggg taggcacaaa tttatgtaaa     2040

tagtgctcct tctctttagt atgtttgctt tgggggtaga aaaatggttt taacaaacac     2100

tggtttccat caaatgaatg atgtcttctc catcctgtgg agacaagaat ctgctagaag     2160

gatatgtgct aagttcctta taagagataa tggtgctctg cctatgccag cttggcaccc     2220

gaagatgtgt gagtggacgt gaggctgagt attaccttag tatttttctc tgggtctttg     2280

gaaaaccata gtcaattttt agaacatatt gctttcattc cccataaact cttcacacat     2340

gataactgtt taagctttga aaacacatac tgaagtattg tgagcttaaa aaaacttttt     2400

aaatatttgc atagttttga ggtgaatttg tttccttaca gatctctcct aatcattgag     2460

atgtatattt caaaagagga aattttacat gttgtccaaa acagccttgc tagtaactgg     2520

tgaattttgg tattaactat tattaaagtc tttaaacgac acaggtacct aaagatcacc     2580

ttaatgtggc aatttgtgat ggtgtagcta gctgattgtg aaaactgttc ctttaaagtc     2640

gcttcttgca tgttcggtgt tagtcatcca gctcaggctt gtgttgcagc tgacaatcta     2700

ggaaagacgg ccttagagag tggtgcaggc cccacactga cggactgcct tagaaacccg     2760

acttcctcta gactttgaac cgccagactt ttctcttgtt tagaaaacaa acttatattt     2820

aatgtactta ctacttaaaa ctccagacag agatataatg tagaaggcaa atattggcca     2880

attttttcct ctttttaagt ggaagacaaa tgaacgggat ttttaaagtg cttttaaagt     2940

gcatgaatgg ttaataaatc agtatgaatt gtaagccttc atcttacatc caagtcctta     3000

gttggttagg gtttcttttc tttctttttt aaagagtgtc aattaccttt tgaacctgtg     3060

aaaatttgat agttgttaac agtctgatgg tcctaattct ttcttttcat tctagaaatg     3120

aatgtggttg taatcatgtt cctaattctt gggacaacct gcaagacagt gagacagttt     3180

aaaaattacc tttcatgttg aaaaagtctg aaacagagaa cccaatgata tttaaaataa     3240

atgctacata aaactctttt taaaattttg attttaactt aattaaaaca atgtcataaa     3300

tatgcttttt gattttgtta ctgcttttaa tattaaagta atagaatatt gaagcaatat     3360

tgtctagcac tctgctggac attaagtccg cgggaggaga agtgaacagg aatcgattct     3420

ttgtctttta actgccctta gttaggagat gttaaaatac ttggcacctc tggttatatg     3480

tatgttatgt gtgttctccc ccctaaaatt tctaagcaca tttattcact tttaaaatga     3540

atctttaaaa gattatagtt agtagttata gttaatattc tatttacttg gaaaaatgtg     3600

aataaatgga tcttcaaaag attcatttta aaaatgaata aatgtataat aggctatagg     3660

tgatcttact tgcgtattag gtaggaggca catatttata ccatttcata tgtaatatct     3720

ttgtcattgt gtttcatcga agatcaattg ctagcaactt gaagggtatt tatacttggg     3780

tcacttgaac tcagctgact aaattgtaag aacgagagca agcaagatgg ctgttattgg     3840

aagccataac ttccagaaga taattctgca caattcgtaa gttaaaaaaa atctgtaggg     3900

tcttccacta tcctttttca ggttgataat gctgttctgg gcacacactt tgtaaatgga     3960

atgttatggt acagtcgcct ctcagtatcc atggggcatt ggttccaggc ctcccttagg     4020

atgccaaact ccatggatac tcaaacccct tctataaaat ggtgtagtat ttgcatatat     4080

cctagacaca tcctcctgta tgctttaaat catctctaga ttacttaaaa tacctaatac     4140

aatgtaaatg ctctgtaaat agttgttata ctatattgtt tagggaataa tgacaaggaa     4200

aaaaaagcct gtacatgttc agcacaagtg aaaccatcct ttttgccccc aaatattttc     4260

aatttgtatt tggttgaatc catggatgca gaactcacgg atacagaggg ccgactgtac     4320

tttctttaaa gtgttcaaaa gtattactag caaagaggag gaggagcaaa gcatatatca     4380

gaagtaaaac aatttttctt gttgactgct ttggtaaaaa acagtttgat ggatagtttt     4440

acatttcact ggactagata aaaaatggtg ctaatattta tgtagcttga tgctatagtt     4500

gctttggtat caaacttaat acctaaccca tataagatcc ttattatata attttgtgat     4560

cagtaaaatg atattttaaa gagtgatctt aaaaatatga cctggtcatt gcacaacgtt     4620

tgcatttgaa atgaatttgt gtactatagg gtggatatgg agttattcag tgcaagtgtg     4680

tgcttaatat caaaccctat gcaaggagct atgtctagat ttttggtcca aatttgcctc     4740

cttcaagcct actagtgtga gatggaaaaa aatcgattgc tcttttaata ttatttccat     4800

tttgaaattc tcgacacttg aatgaaggca gtagaggcct ctttttggat ttctcttcta     4860

ataacaaaac tttatttagg gaaggtttcc ctgtgctatc gtaagtttgt tttgagcact     4920

gcattcactt taaaattctg gaggaacaaa ggctgggcac ataatcacaa agcccaggcc     4980

acacaataat tcggggttgt attttctaag aactatgtat tgtttttagc ttatagttaa     5040

tattgtattt acttggaaaa atgtgaataa agttaattaa cattacaag                 5089


<210> 1556
<211> 2511
<212> DNA
<213> Homo sapiens

<400> 1556
ctacgtcccg cgtcccccga gcgctcggag cctacgcgcc cagcgctacc gaaacccaga       60

gtcctgcgcc ctggagtccc cgcgccccgg agcccgagca cccgggagtc ccgagcctcg      120

cgccccggag tgcccgagcc tgcgccgccg cacccggata ccccgcgtcc ccgcgagctg      180

ccgaggccgc ccgccgccgc cccgcggaca gtaccgcctt cctcccctct gtccgcgcca      240

tggccgcccc cgacctgtcc accaacctcc aggaggaggc cacctgcgcc atctgcctcg      300

actacttcac ggatccggtg atgaccgact gcggccacaa cttctgccgc gagtgcatcc      360

ggcgctgctg gggccagccc gagggcccgt acgcgtgccc cgagtgccgc gagctgtccc      420

cgcagaggaa cctgcggccc aaccgcccgc ttgctaagat ggccgagatg gcgcggcgcc      480

tgcacccgcc gtcgccggtc ccgcagggcg tgtgccccgc gcaccgcgag ccactggccg      540

ccttctgtgg cgacgagctg cgcctcctgt gtgcggcctg cgagcgctct ggggagcact      600

gggcgcaccg cgtgcggccg ctgcaggacg cggccgaaga cctcaaggcg aagctggaga      660

agtcactgga gcatctccgg aagcagatgc aggatgcgtt gctgttccaa gcccaggcgg      720

atgagacctg cgtcttgtgg cagaagatgg tggagagcca gcggcagaac gtgctgggtg      780

agttcgagcg tcttcgccgt ttgctggcag aggaggagca gcagctgctg cagaggctgg      840

aggaggagga gctggaggtg ctgccccggc tgcgggaggg cgcagcccac ctaggccagc      900

agagcgccca cctagctgag ctcatcgccg agctcgaggg ccgctgccag ctgcctgctc      960

tggggctgct gcaggacatc aaggacgccc tgcgcagggt ccaggatgtg aagctgcagc     1020

ccccagaagt tgtgcctatg gagctgagga ccgtgtgcag ggtcccggga ctggtagaga     1080

cactgcggag gtttcgaggt aggtgtggag gccccaggtg gggagatgac tccaggaggg     1140

gacctgccaa ggacctgggc agccagccac gtgttctgtg ccctgccact gccagctcca     1200

aactcacagt gtcatggtgg tgggttgttg ggaaaacgtc ctctgctcat acttctgaca     1260

tcagttgtgt gggtattttc acaccaaaca attcttcaac ttctggaaac gaattgggta     1320

tccaaggatt ccattcagca ttgaacagaa ttgccagtgc tgacactaca ggagttagta     1380

cagaccccac agattaaggg ctcagtccca taagactgcc cccacttcag atgccagtca     1440

caacttccag gggctgccca tacttctgtt ccctcagcgc ctctgcagat gtgagcattc     1500

gctagcacag cccatggaac tcagaagagc actttactta ctgtcattgg tttattgtga     1560

aggataccac tcaggaagag ccaaatggaa gagacacatg ggcaaagcct ggggaagggc     1620

tcagagcttt cccaccctcc ctgggtgcac cttcccagca cctcagtgtg ctcaccaacc     1680

tggaaactcc ctgagcccca agagctgttt aggtgtcttt gtggaggttc cattacatgg     1740

ttatgattga ttaaatcatt ggtcattggt gatggggctc aacctcagac ccctttcccc     1800

ttcctgaggt cagaggctgg ggctgagtgt tcccgccctc tactgacagg attggtcttt     1860

ctggtggctg gccttatgct gggctctcag gtccccacct cagccactgc agtggcatca     1920

actcaggtgt gatggaaagg ggcatcttat gatagcacaa gatgcttcta tcagtcagga     1980

aattcccagg gttctgtgag ctctgcgcca ggaactgggc acaaaaccca aatctgagtc     2040

ttgtatcaca gtcacccaaa ggaagtacta tcctcagctc ttgctagcag gtcaggagcc     2100

tgttgtgtag gaactgtgtg caggcctcca gaggtggata gatctgaaat cggagtggtc     2160

agggttggga cagctgccct aattcacatc cttcatttgg agattgaaag gaaaaacaga     2220

ctggatgcat tggctcacct ctgtaatccc agcactttga gaggctcagg cgggaggatt     2280

gcttgaggcc atcagttcaa gaccaacccg ggaaacatag caagactccc atctctacaa     2340

ataaaaaaca aaaaaatgag ccagccatgg tggcacacgc ctgtaatccc agcagcttgg     2400

gaggatctga ggcgggagga tcatttgagc ccaggagatc aaggctgcag tgagccatga     2460

tcgcaccact gcactgcagc ctggggccac agagcaagac cctgcctctt t              2511


<210> 1557
<211> 2534
<212> DNA
<213> Homo sapiens

<400> 1557
caggatgcag aggccacgga ggagggctgg gccagcttct cctgtgagct gtcccacgag       60

gatgaggagg tcgagtggtc gctcaacggg atgcccctgt acaacgacag cttccatgag      120

atctcacaca agggccggcg ccacacgctg gtactgaaga gcatccagcg ggctgatgcg      180

ggcatagtac gcgcctcctc cctgaaggtg tcgacctctg cccgcctgga ggtccgagtg      240

aagccggtgg tgttcctgaa ggcgctggat gacctgtccg cagaggagcg cggcaccctg      300

gccctgcagt gtgaagtctc tgaccccgag gcccatgtgg tgtggcgcaa agatggcgtg      360

cagctgggcc ccagtgacaa gtatgacttc ctgcacacgg cgggcacgcg ggggctcgtg      420

gtgcatgacg tgagccctga agacgccggc ctgtacacct gccacgtggg ctccgaggag      480

acccgggccc gggtccgcgt gcacgatctg cacgtgggca tcaccaagag gctgaagaca      540

atggaggtgc tggaagggga aagctgcagc tttgagtgcg tcctgtccca cgagagtgcc      600

agcgacccgg ccatgtggac agtcggtggg aagacagtgg gcagctccag ccgcttccag      660

gccacacgtc agggccgaaa atacatcctg gtggtccggg aggctgcacc aagtgatgcc      720

ggggaggtgg tcttctctgt gcggggcctc acctccaagg cctcactcat tgtcagagag      780

aggccggccg ccatcatcaa gcccctggaa gaccagtggg tggcgccagg ggaggacgtg      840

gagctgcgct gtgagctgtc acgggcggga acgcccgtgc actggctgaa ggacaggaag      900

gccatccgca agagccagaa gtatgatgtg gtctgcgagg gcacgatggc catgctggtc      960

atccgcgggg cctcgctcaa ggacgcgggc gagtacacgt gtgaggtgga ggcttccaag     1020

agcacagcca gcctccatgt ggaagaaaaa gcaaactgct tcacagagga gctgaccaat     1080

ctgcaggtgg aggagaaagg cacagctgtg ttcacgtgca agacggagca ccccgcggcc     1140

acagtgacct ggcgcaaggg cctcttggag ctacgggcct cagggaagca ccagcccagc     1200

caggagggcc tgaccctgcg gctcaccatc agtgccctgg agaaggcaga cagcgacacc     1260

tatacctgcg acattggcca ggcccagtcc cgggcccagc tcctagtgca aggtgaggcg     1320

gccaagtgtg ctcgggccta ggctttgaat ggcacggaga cttggaggtg gacaggccca     1380

gcctcagttt cttatcatga gggtataggg ggtgcaccct gggtggtcac tgaggctccc     1440

cagcatggct gtgaatgagc tgctggtgct cacttactcg tgtgtttatt tggtcactgt     1500

gtgtttctcc cacatgcccc gtgtgcctgg cccccatgcg taagctcagc gtgtatccgt     1560

acataaaacg tgtcaccctt atcccagagg gacagcctga ctcagccgtg ccaggcagcc     1620

tcaggtgctc ccagggaaga actgatggtc attagggttg tcattgagag ttacagtggc     1680

attttagtct ttttcttgtt gtttacaaca gaatacctga aactgggtaa tttataaagg     1740

aaataaattt acttcttaca gctctggagg ctgggaagtc caaggtcaag gggccacatc     1800

tggtgagggc ccttttgctg acaggaactc tctgcagagt ccccaaggga cggcacaggg     1860

catcccatgg ggagggggct gagtgtgcta gcttgggcct ctcttcatct tcttttaaag     1920

ccaccactca tatggaagca ctttaaccca ttaacctgtt aacccgttga tccatgaatg     1980

ggttaatcca ttcccgcctt ggacccaatc ccctcttaaa ggctccacct cttaatattg     2040

ccacattggg attaagtttc aacatgagtt tccaggggga cattcagatc atagtaggtg     2100

gctgttcgat cttactgttt ggctccacat ttgagtggca ggcagagtga gagctgtcat     2160

tctctcaact ctgtagataa gaaaactgaa gctttagtgg gtccatggcc agggcaaggt     2220

catcaggcac attgggatca gagcaggcga ggcccagccc catcaccgca gccttcactt     2280

ggctctgaag tcccgggctg gtgtccagag ctgagtttgc aggaggtccc tactggggtc     2340

tgaccacagg gcgttcacag ggttcagtat ttgaaaggcc ccagttgtga tcatcagaag     2400

taacgtaaac caggaatcat cactgatttt ttctctccaa tggatttggt gaccctggtg     2460

aaagtattct gttagcacag taacgcccca tgatctaata aagttggtac ccagagttaa     2520

tttttaaaaa agtc                                                       2534


<210> 1558
<211> 2712
<212> DNA
<213> Homo sapiens

<400> 1558
ctgacaacgt gcgcatccgc caggaaggaa ggacatacac tctcatctac cggagagtcc       60

tggcggaaga tgcaggagag atccaatttg tagccgaaaa tgcagaatcg cgagcccagc      120

tccgagtgaa ggagctgcca gtgaccctcg tgcgcccgct gcgggacaag attgccatgg      180

agaagcaccg cggtgtgctg gagtgtcagg tgtcccgggc cagcgcccag gtgcggtggt      240

tcaagggcag tcaggagctg cagcccgggc ccaagtacga gctggtcagt gatggcctct      300

accgcaagct gatcatcagt gatgtccacg cagaggacga ggacacctac acctgtgacg      360

ccggtgatgt caagaccagt gcacagttct tcgtggaaga gcaatccatc accattgtgc      420

ggggtctgca ggacgtgaca gtgatggagc ccgctcctgc ctggtttgag tgtgagacct      480

ccatcccctc agtgcggcca cctaagtggc tcctggggaa gacggtgttg caggctgggg      540

ggaacgtggg cctggagcag gagggcacgg tgcaccggct gatgctgcgg cggacctgct      600

ccaccatgac cgggcccgtg cacttcaccg ttggcaagtc gcgctcctct gcccgcctgg      660

tggtctcaga catccccgta gtcctcacac ggccgttgga gcccaagaca gggcgtgagc      720

tgcagtcagt ggtcctgtcc tgcgacttcc ggccagcccc caaggctgtg cagtggtaca      780

aggatgacac gcccctgtct ccctctgaga agtttaagat gagcctggag ggtcagatgg      840

ctgagctgcg catcctccgg ctcatgcctg ctgatgctgg tgtctaccgg tgccaggcgg      900

gcagtgccca cagcagcact gaggtcactg tggaagcgcg ggaggtgaca gtgacagggc      960

cgctacagga tgcagaggcc acggaggagg gctgggccag cttctcctgt gagctgtccc     1020

acgaggatga ggaggtcgag tggtcgctca acgggatgcc cctgtacaac gacagcttcc     1080

atgagatctc acacaagggc cggcgccaca cgctggtact gaagagcatc cagcgggctg     1140

atgcgggcat agtacgcgcc tcctccctga aggtgtcgac ctctgcccgc ctggaggtcc     1200

gagtgaagcc ggtggtgttc ctgaaggcgc tggatgacct gtccgcagag gagcgcggca     1260

ccctggccct gcagtgtgaa gtctctgacc ccgaggccca tgtggtgtgg cgcaaagatg     1320

gcgtgcagct gggccccagt gacaagtatg acttcctgca cacggcgggc acgcgggggc     1380

tcgtggtgca tgacgtgagc cctgaagacg ccggcctgta cacctgccac gtgggctccg     1440

aggagacccg ggcccgggtc cgcgtgcacg atctgcacgt gggcatcacc aagaggctga     1500

agacaatgga ggtgctggaa ggggaaagct gcagctttga gtgcgtcctg tcccacgaga     1560

gtgccagcga cccggccatg tggacagtcg gtgggaagac agtgggcagc tccagccgct     1620

tccaggccac acgtcagggc cgaaaataca tcctggtggt ccgggaggct gcaccaagtg     1680

atgccgggga ggtggtcttc tctgtgcggg gcctcacctc caaggcctca ctcattgtca     1740

gagagaggcc ggccgccatc atcaagcccc tggaagacca gtgggtggcg ccaggggagg     1800

acgtggagct gcgctgtgag ctgtcacggg cgggaacgcc cgtgcactgg ctgaaggaca     1860

ggaaggccat ccgcaagagc cagaagtatg atgtggtctg cgagggcacg atggccatgc     1920

tggtcatccg cggggcctcg ctcaaggacg cgggcgagta cacgtgtgag gtggaggctt     1980

ccaagagcac agccagcctc catgtggaag aaaaagcaaa ctgcttcaca gaggagctga     2040

ccaatctgca ggtggaggag aaaggcacag ctgtgttcac gtgcaagacg gagcaccccg     2100

cggccacagt gacctggcgc aagggcctct tggagctacg ggcctcaggg aagcaccagc     2160

ccagccagga gggcctgacc ctgcggctca ccatcagtgc cctggagaag gcagacagcg     2220

acacctatac ctgcgacatt ggccaggccc agtcccgggc ccagctccta gtgcaaggtg     2280

aggcggccaa gtgtgctcgg gcctaggctt tgaatggcac ggagacttgg aggtggacag     2340

gcccagcctc agtttcttat catgagggta tagggggtgc accctgggtg gtcactgagg     2400

ctccccagca tggctgtgaa tgagctgctg gtgctcactt actcgtgtgt ttatttggtc     2460

actgtgtgtt tctcccacat gccccgtgtg cctggccccc atgcgtaagc tcagcgtgta     2520

tccgtacata aaacgtgtca cccttatccc agagggacag cctgactcag ccgtgccagg     2580

cagcctcagg tgctcccagg gaagaactga tggtcattag ggttgtcatt gagagttaca     2640

gtggcatttt agtctttttc ttgttgttta caacagaata cctgaaactg ggtaatttat     2700

aaaggaaata aa                                                         2712


<210> 1559
<211> 25575
<212> DNA
<213> Homo sapiens

<400> 1559
gctgcccaga gcccccatag agagaggtcc ccgccgccac cctcatggat cagccacagt       60

tcagcggggc gccccgcttt ctcacccggc ccaaggcctt cgtggtgtcg gtgggcaagg      120

acgccaccct cagctgccag atcgtgggta atcccacgcc acaggtgagc tgggagaagg      180

accagcagcc ggtggcggcc ggcgcgcgct tccgtctggc ccaggacggc gacctctacc      240

gcctcactat cctggacctg gcgctgggcg acagtgggca atacgtgtgc cgcgcgcgca      300

atgccatagg cgaggccttc gctgctgtgg gcctgcaggt ggacgcggag gccgcgtgcg      360

ccgagcaggc gccgcacttc ctgctgcggc ccacgtccat ccgcgtgcgc gagggctcag      420

aggccacctt ccgctgccgc gtgggtggct ccccgaggcc ggcagtgagc tggtccaagg      480

acgggcggcg cctgggtgag cccgacggcc cccgcgtgcg cgtggaggag ctcggcgagg      540

caagtgcgct gcgcattcgg gcggcgcggc cgcgcgacgg cggcacttac gaggtccgcg      600

ccgagaaccc gctgggcgct gccagcgccg ccgcggcgct agtggtggac tcggacgccg      660

cggacacggc cagccggccc gggacctcca cggccgcgct cctggcgcac ctgcagcggc      720

ggcgcgaggc tatgcgcgcc gagggcgccc ccgcctcacc gcccagcacc ggcacgcgca      780

cctgcacggt gactgaaggc aagcacgcgc gcctcagctg ctacgtgacc ggcgagccca      840

agcccgagac ggtgtggaag aaggacggcc agctggtgac cgagggccgg cgccacgtgg      900

tgtacgagga cgcgcaggag aacttcgtgc tcaagatcct cttctgcaag cagtcggacc      960

gcggcctcta cacctgcacg gcgtccaacc tcgtgggcca gacctacagc tctgtgctgg     1020

tcgtagtgcg cgagcccgcg gttcccttca aaaagcggct gcaagatctg gaggtgcggg     1080

agaaggagtc ggccacgttc ctatgtgagg tgccccagcc gtccactgag gccgcgtggt     1140

tcaaggagga gacgcggttg tgggcgagcg ccaagtacgg catcgaggag gagggcaccg     1200

agcgccgcct gaccgtgcgc aatgtctcgg ccgacgacga cgcggtgtac atctgcgaga     1260

cgccagaggg cagccgcacg gtggcggagc tcgcagtcca aggaaacctc ctccgaaagc     1320

tccctcggaa gacggcggtg cgcgtgggcg acacggctat gttttgcgtg gagctggcgg     1380

tcccggtggg ccccgtccac tggctgcgga accaggagga agtggtggcg gggggccgcg     1440

tggccatctc cgcggagggc acgcgccaca cactaaccat ctcccagtgc tgcctggagg     1500

atgtgggcca ggtggccttt atggctggcg actgccagac gtccacccag ttctgcgtgt     1560

cggcccccag gaagcctccc ctgcaacccc ctgtggatcc tgtggtaaag gccaggatgg     1620

agagttccgt gattctcagc tggtccccac caccccatgg ggaacgccct gtcactatcg     1680

acggctacct ggtagagaag aagaagcttg gcacctacac ctggatcagg tgccacgagg     1740

ctgaatgggt ggctacacct gagctgaccg tggctgatgt ggcggaggag gggaacttcc     1800

agttccgagt gtccgctctc aacagctttg gtcagagtcc ctacctcgag ttcccgggga     1860

ctgtccacct ggcccccaag ctggccgtga ggacaccgct gaaggcggtg caggcggtag     1920

agggtggcga ggtcactttc tccgtggacc tcacggtggc ctcagcgggt gagtggttcc     1980

tggatgggca ggccctgaag gccagcagtg tgtatgagat ccactgtgat cgcacccggc     2040

acacgctcac catccgggag gtgcccgcca gcctgcacgg ggcgcagctg aagttcgtgg     2100

ccaacggcat tgagagcagc atccggatgg aggtccgggc ggccccaggg ctgactgcca     2160

acaagccgcc agccgcagct gcccgggagg tgctggctcg gctgcacgag gaggcgcagc     2220

tgctggctga gctgtcagat caggctgcgg ctgtgacgtg gctgaaggat ggtcgcacac     2280

tgtccccagg ccccaagtat gaggtgcagg catcggccgg gcggcgggtg ctccttgtgc     2340

gagatgtggc ccgggacgat gcaggcctct acgagtgcgt cagccgcggg ggccgcatcg     2400

cctaccagct ctccgtgcaa ggcctcgcgc gctttctgca caaggacatg gcgggcagct     2460

gtgtggatgc cgtggctggg ggcccggcgc agtttgagtg tgagacctcc gaagcccacg     2520

tccacgtgca ctggtacaag gatggcatgg agctgggcca ctccggtgag cgcttcttgc     2580

aggaggatgt ggggacgcgg caccggctgg tggcagccac agtcaccagg caggatgaag     2640

gcacctactc ctgccgcgtg ggcgaggact ctgtggactt ccggctccgc gtctctgagc     2700

ccaaggtggt gtttgctaag gagcagctgg cacgcaggaa gctgcaggca gaggcaggag     2760

ccagtgccac actgagctgc gaggtggccc aggcccagac ggaggtgacg tggtacaagg     2820

atgggaagaa gctgagctcc agctcgaaag tgtgcatgga ggccacaggc tgcacgcgca     2880

ggctggttgt gcagcaggca ggccaggcgg atgccgggga gtatagctgc gaggctgggg     2940

gccagcggct ctccttccat ctggatgtca aagagcccaa ggtggtgttt gccaaggacc     3000

aggtggcaca cagtgaggtg caggctgagg caggggccag tgccacgctg agctgcgagg     3060

tggcccaggc ccagacggag gtgatgtggt acaaagatgg gaagaagctg agctccagct     3120

tgaaagtgca tgtagaggcc aagggctgca gacggaggct ggtggtgcag caggcaggca     3180

agacagatgc cggggactac agctgcgagg ccaggggcca gagggtctcc ttccgcctgc     3240

acatcacaga gcccaagatg atgtttgcaa aggagcagtc agtgcataat gaggtgcagg     3300

ctgaggcggg ggccagtgcc atgctgagct gtgaggtggc ccaggcccag acggaggtga     3360

cgtggtacaa ggatgggaag aagctgagct ccagctcaaa agtgggcatg gaggtcaaag     3420

ggtgcacacg gaggctggtg ctgccacagg cgggcaaagc agatgctggg gagtacagct     3480

gtgaggctgg gggccagaga gtctccttcc acctgcacat cacagagccc aagggggtgt     3540

ttgcgaagga gcagtcagtg cataatgagg tgcaggctga ggcggggacc actgccatgc     3600

tgagctgtga ggtggcccag ccccagacag aggtgacgtg gtacaaggac gggaagaagc     3660

tgagctccag ctcaaaagta cgcatggagg tcaagggctg cacacgaagg ctggtagtgc     3720

agcaggtggg caaagcagat gctggggagt acagctgcga ggctgggggc cagagagtct     3780

cctttcaact gcacatcaca gagcccaagg cagtgtttgc caaggagcag ttggtgcata     3840

atgaggtgcg gactgaggca ggggccagtg ccacactgag ctgtgaggtg gcccaggccc     3900

agacagaggt gacgtggtac aaggatggga agaagctgag ctccagttcg aaagtgcgca     3960

tagaggctgc gggctgcatg cggcagctgg tggtgcagca ggcaggccag gcagatgctg     4020

gggagtacac ctgtgaggct gggggccagc ggctctcctt ccacctggat gtttcagagc     4080

ccaaggcggt gtttgcaaag gagcagctgg cacacaggaa ggtgcaggcc gaggcggggg     4140

ccattgccac gctgagctgc gaggtggccc aggcccagac agaggtgacg tggtacaagg     4200

acgggaagaa gctgagctcc agctcgaaag ttcgaatgga ggctgtgggc tgcacacgga     4260

ggctggtggt gcagcaggca tgccaggcgg acaccgggga gtatagctgc gaggccgggg     4320

gccagcggct ctccttcagc ctggacgtgg cagagcccaa ggtggtgttt gccaaggagc     4380

agccagtgca cagggaggtg caggcccagg cgggggccag caccacactc agctgcgagg     4440

tggctcaggc ccagacggag gtgatgtggt acaaggacgg gaagaagctg agcttcagct     4500

cgaaagtgcg catggaggct gtgggctgca cacggaggct ggtggtgcag caggcgggcc     4560

aggcggtcgc cggggagtac agctgcgagg cggggagcca gcggctctcc ttccacctgc     4620

acgtggcaga gcccaaggcg gtgtttgcca aggagcagcc agcgagcagg gaggtgcagg     4680

ctgaggcggg gaccagtgcc acgctgagct gcgaggtggc ccaggcccag acagaggtga     4740

cgtggtacaa ggacgggaag aaactgagct ccagctcgaa agtgcgaatg gaggccgtgg     4800

gctgcacacg gaggctggtg gtgcaggagg caggccaggc ggacgccggg gagtacagct     4860

gcaaggccgg ggatcagcgg ctgtccttcc acctgcacgt ggcagagccc aaggtggtgt     4920

ttgccaagga gcagccagca cacagggagg tgcaggctga ggcgggggcc agtgccacgc     4980

tgagctgcga ggtggcccag gcccagacag aggtgacgtg gtacaaggat gggaagaagc     5040

tgagttccag ctcgaaagtg cgcgtggagg ccgtgggctg cacacggagg ctggtggtgc     5100

agcaggcggg ccaggcagag gccggggagt acagctgcga ggcagggggt cagcagctct     5160

ccttccgcct gcaggtggca gagctggagc cccaaatttc agagagaccc tgccgcaggg     5220

agcctctggt ggtcaaggag catgaagaca tcatcctgac cgccacactg gccacaccct     5280

ctgcggccac ggtgacctgg ctcaaggatg gtgtggagat tcgccgcagc aagcggcatg     5340

agacagccag ccagggggac acccacaccc tgaccgtgca tggcgcccag gttctggaca     5400

gcgccatcta cagctgccgt gtgggcgcag aggggcagga cttcccagtg caggtggaag     5460

aggtggccgc caagttctgc cggctgctgg agcctgtgtg cggcgagctg ggtggcacgg     5520

tgacactggc ctgcgagcta agcccagcgt gtgcagaggt ggtgtggcgc tgcggcaaca     5580

cgcagcttcg ggtgggcaag cgcttccaga tggtggccga ggggcccgtg cgctcactca     5640

ctgtgttggg gctgcgcgca gaggacgcag gggagtacgt gtgtgagagc cgtgatgacc     5700

acaccagtgc gcagctcacc gtcagtgtgc cccgagtggt gaagtttatg tctgggctga     5760

gcaccgtggt cgcagaggag ggcggcgagg ccaccttcca gtgcgtggtg tcccccagtg     5820

atgtggcagt cgtgtggttc cgggacggtg ccctgcttca gcccagcgag aagtttgcca     5880

tatcacagag tggcgccagc cacagcctga ccatctcaga cctggtgctg gaggacgcgg     5940

gccagatcac cgtggaggct gagggcgcct catcctctgc tgccctgagg gtccgagagg     6000

cgcctgtgct gttcaaaaag aagctggagc cgcagacggt ggaggagcgg agctcggtga     6060

ccctggaggt ggagctgacg cggccgtggc cggagctgag gtggacacgg aacgcgacgg     6120

ccctggcgcc gggaaagaac gtggagatcc acgccgaggg cgcccgccac cgcctggttc     6180

tgcacaacgt aggttttgcc gaccgtggct tctttggctg cgagacgccg gatgacaaga     6240

cacaggccaa actcaccgtg gagatgcgcc aggtacggct cgtacggggc ctgcaggcag     6300

tggaggcacg ggagcagggc acggctacca tggaggtgca gctgtcgcat gcggacgtgg     6360

atggcagctg gactcgtgac ggtctgcggt tccagcaggg gcccacgtgc cacctggctg     6420

tgcggggccc catgcacacc ctcacactct cggggctgcg gccagaggat agtggcctta     6480

tggtcttcaa ggccgaagga gtgcacacgt cggcgcggct cgtggtcacc gagcttcccg     6540

tgagcttcag ccgcccgctg caggacgtgg tgaccactga gaaggagaag gttaccctgg     6600

agtgcgagct gtcgcgtcct aatgtggatg tgcgctggct gaaggacggt gtggagctgc     6660

gggcaggcaa gacgatggcc atcgcagccc agggcgcctg caggagcctc accatttacc     6720

ggtgcgagtt cgcggatcag ggagtgtatg tgtgtgatgc ccatgatgcc cagagctctg     6780

cctccgtgaa ggtacaagga aggacataca ctctcatcta ccggagagtc ctggcggaag     6840

atgcaggaga gatccaattt gtagccgaaa atgcagaatc gcgagcccag ctccgagtga     6900

aggagctgcc agtgaccctc gtgcgcccgc tgcgggacaa gattgccatg gagaagcacc     6960

gcggtgtgct ggagtgtcag gtgtcccggg ccagcgccca ggtgcggtgg ttcaagggca     7020

gtcaggagct gcagcccggg cccaagtacg agctggtcag tgatggcctc taccgcaagc     7080

tgatcatcag tgatgtccac gcagaggacg aggacaccta cacctgtgac gccggtgatg     7140

tcaagaccag tgcacagttc ttcgtggaag agcaatccat caccattgtg cggggtctgc     7200

aggacgtgac agtgatggag cccgctcctg cctggtttga gtgtgagacc tccatcccct     7260

cagtgcggcc acctaagtgg ctcctgggga agacggtgtt gcaggctggg gggaacgtgg     7320

gcctggagca ggagggcacg gtgcaccggc tgatgctgcg gcggacctgc tccaccatga     7380

ccgggcccgt gcacttcacc gttggcaagt cgcgctcctc tgcccgcctg gtggtctcag     7440

acatccccgt agtcctcaca cggccgttgg agcccaagac agggcgtgag ctgcagtcag     7500

tggtcctgtc ctgcgacttc cggccagccc ccaaggctgt gcagtggtac aaggatgaca     7560

cgcccctgtc tccctctgag aagtttaaga tgagcctgga gggtcagatg gctgagctgc     7620

gcatcctccg gctcatgcct gctgatgctg gtgtctaccg gtgccaggcg ggcagtgccc     7680

acagcagcac tgaggtcact gtggaagcgc gggaggtgac agtgacaggg ccgctacagg     7740

atgcagaggc cacggaggag ggctgggcca gcttctcctg tgagctgtcc cacgaggatg     7800

aggaggtcga gtggtcgctc aacgggatgc ccctgtacaa cgacagcttc catgagatct     7860

cacacaaggg ccggcgccac acgctggtac tgaagagcat ccagcgggct gatgcgggca     7920

tagtacgcgc ctcctccctg aaggtgtcga cctctgcccg cctggaggtc cgagtgaagc     7980

cggtggtgtt cctgaaggcg ctggatgacc tgtccgcaga ggagcgcggc accctggccc     8040

tgcagtgtga agtctctgac cccgaggccc atgtggtgtg gcgcaaagat ggcgtgcagc     8100

tgggccccag tgacaagtat gacttcctgc acacggcggg cacgcggggg ctcgtggtgc     8160

atgacgtgag ccctgaagac gccggcctgt acacctgcca cgtgggctcc gaggagaccc     8220

gggcccgggt ccgcgtgcac gatctgcacg tgggcatcac caagaggctg aagacaatgg     8280

aggtgctgga aggggaaagc tgcagctttg agtgcgtcct gtcccacgag agtgccagcg     8340

acccggccat gtggacagtc ggtgggaaga cagtgggcag ctccagccgc ttccaggcca     8400

cacgtcaggg ccgaaaatac atcctggtgg tccgggaggc tgcaccaagt gatgccgggg     8460

aggtggtctt ctctgtgcgg ggcctcacct ccaaggcctc actcattgtc agagagaggc     8520

cggccgccat catcaagccc ctggaagacc agtgggtggc gccaggggag gacgtggagc     8580

tgcgctgtga gctgtcacgg gcgggaacgc ccgtgcactg gctgaaggac aggaaggcca     8640

tccgcaagag ccagaagtat gatgtggtct gcgagggcac gatggccatg ctggtcatcc     8700

gcggggcctc gctcaaggac gcgggcgagt acacgtgtga ggtggaggct tccaagagca     8760

cagccagcct ccatgtggaa gaaaaagcaa actgcttcac agaggagctg accaatctgc     8820

aggtggagga gaaaggcaca gctgtgttca cgtgcaagac ggagcacccc gcggccacag     8880

tgacctggcg caagggcctc ttggagctac gggcctcagg gaagcaccag cccagccagg     8940

agggcctgac cctgcggctc accatcagtg ccctggagaa ggcagacagc gacacctata     9000

cctgcgacat tggccaggcc cagtcccggg cccagctcct agtgcaaggc cggagagtgc     9060

acatcatcga ggacctggag gatgtggatg tgcaggaggg ctcctcggcc accttccgtt     9120

gccggatctc cccggccaac tacgagcctg tgcactggtt cctggacaag acacccctgc     9180

atgccaacga gctcaatgag atcgatgccc agcccggggg ctaccacgtg ctgaccctgc     9240

ggcagctggc gctcaaggac tcgggcacca tctactttga ggcgggtgac cagcgggcct     9300

cggccgccct gcgggtcact gagaagccaa gcgtcttctc ccgggagctc acagatgcca     9360

ccatcacaga gggtgaggac ttgaccctgg tgtgcgagac cagcacctgc gacattcctg     9420

tgtgctggac caaggatggg aagaccctgc gggggtctgc ccggtgccag ctgagccatg     9480

agggccaccg ggcccagctg ctcatcactg gggccaccct gcaggacagt ggacgctaca     9540

agtgtgaggc tgggggcgcc tgcagcagct ccattgtcag ggtgcatgcg cggccagtgc     9600

ggttccagga ggccctgaag gacctggagg tgctggaggg tggtgctgcc acactgcgct     9660

gtgtgctgtc atctgtggct gcgcccgtga agtggtgcta tggaaacaac gtcctgaggc     9720

caggtgacaa atacagccta cgccaggagg gtgccatgct ggagctggtg gtccggaacc     9780

tccggccgca ggacagcggg cggtactcat gctccttcgg ggaccagact acttctgcca     9840

ccctcacagt gactgccctg cctgcccagt tcatcgggaa actgagaaac aaggaggcca     9900

cagaaggggc cacggccacg ctgcggtgtg agctgagcaa ggcagcccct gtggagtgga     9960

gaaaggggtc cgagaccctc agagatgggg acagatactg tctgaggcag gacggggcca    10020

tgtgtgagct gcagatccgt ggcctggcca tggtggatgc cgcggagtac tcgtgtgtgt    10080

gtggagagga gaggacctca gcctcactca ccatcaggcc catgcctgcc cacttcatag    10140

gaagactgag acaccaagag agcatagaag gggccacagc cacgctgcgg tgtgagctga    10200

gcaaggcggc ccccgtggag tggaggaagg ggcgtgagag cctcagagat ggggacagac    10260

atagcctgag gcaggacggg gctgtgtgcg agctgcagat ctgtggcctg gctgtggcag    10320

atgctgggga gtactcctgt gtgtgtgggg aggagaggac ctctgccact ctcaccgtga    10380

aggccctgcc agccaagttc acagagggtc tgaggaatga agaggccgtg gaaggggcca    10440

cagccatgtt gtggtgtgaa ctgagcaagg tggcccctgt ggagtggagg aaggggcccg    10500

agaacctcag agatggggac agatacatcc tgaggcagga ggggaccagg tgtgagctgc    10560

agatctgtgg cctggccatg gcggacgccg gggagtactt gtgtgtgtgc gggcaggaga    10620

ggacctcagc cacgctcacc atcagggctc tgcctgccag gttcatagaa gatgtgaaaa    10680

accaggaggc cagagaaggg gccacagctg tgctgcagtg tgagctgaac agtgcagccc    10740

ctgtggagtg gagaaagggg tctgagaccc ttagagatgg ggacagatac agcctgaggc    10800

aggacgggac taaatgtgag ctgcagattc gtggcctggc catggcagac actggggagt    10860

actcgtgcgt gtgcgggcag gagaggacct cggctatgct caccgtcagg gctctaccca    10920

tcaagttcac agagggtctg aggaacgaag aggccacaga aggggcaaca gccgtgctgc    10980

ggtgtgagct gagcaagatg gcccccgtgg agtggtggaa ggggcatgag accctcagag    11040

atggagacag acacagcctg aggcaggacg gggccaggtg tgagctgcag atccgcggcc    11100

tcgtggcaga ggacgctggg gagtacctgt gcatgtgcgg gaaggagagg acctcagcca    11160

tgctcaccgt cagggccatg ccttccaagt tcatagaggg tctgaggaat gaagaggcca    11220

cagaagggga cacggccacg ctgtggtgtg agctgagcaa ggcggcaccg gtggagtgga    11280

ggaaggggca tgagaccctc agagatgggg acagacacag cctgaggcag gacgggtcca    11340

ggtgtgagct gcagatccgt ggcctggctg tggtggatgc cggggagtac tcgtgtgtgt    11400

gcgggcagga gaggacctca gccacactca ctgtcagggc cctgcctgcc agattcatag    11460

aagatgtgaa aaaccaggag gccagagaag gggccacggc cgtgctgcaa tgtgagctga    11520

gcaaggcggc ccccgtggag tggaggaagg ggtctgagac cctcagaggt ggggacagat    11580

acagcctgag gcaggatggg accagatgtg agctgcagat tcatggcctg tctgtggcag    11640

acactgggga gtactcgtgt gtgtgcgggc aggagaggac ctcggccaca ctcaccgtca    11700

gggccctgcc tgcacgattc actcaagatc tgaagaccaa ggaggcctca gaaggggcca    11760

cagctacact gcagtgtgag ctgagcaagg tggcccctgt ggaatggaag aagggtcctg    11820

agaccctcag agatgggggc agatacagcc tgaagcagga tgggacgagg tgtgagctgc    11880

agatccatga cctgtctgtg gcggatgctg gggaatactc atgcatgtgt ggacaagaga    11940

ggacctcggc cacgctcact gtcagggccc tgcctgccag gttcacagag ggtctgagga    12000

atgaagaggc catggaaggg gccacagcca cactgcaatg tgagctgagc aaggcagccc    12060

ctgtggagtg gaggaaaggc cttgaggctc tcagagatgg ggacaaatac agcctgagac    12120

aagacggggc tgtgtgtgag ctgcagattc atggcctggc tatggcagat aacggggtgt    12180

actcatgtgt gtgtgggcag gagaggacct cagctacact cactgtcagg gccctgcctg    12240

ccagattcat agaggatatg agaaaccaga aggccacaga aggggctaca gtcacattgc    12300

aatgtaagct gagaaaggcg gcccccgtgg agtggagaaa ggggcccaac accctcaaag    12360

atggggacag gtacagcctg aagcaggatg ggaccagttg tgagctgcag attcgtggcc    12420

tggtcatagc agatgctgga gaatactcgt gcatatgtga gcaggagagg acctcggcca    12480

cgctcactgt cagggccctg ccggccagat tcatagaaga tgtgagaaat cacgaggcca    12540

cagaaggggc cacagctgtg ctgcagtgtg agctgagcaa ggcggccccc gtggagtggc    12600

ggaaggggtc tgagaccctc agagatgggg acagatatag cctgaggcag gacgggacga    12660

ggtgtgagct gcagattcgt ggcctggctg tggaggacac tggagagtat ttgtgtgtgt    12720

gcgggcagga gagaacctca gctacactca ctgtcagggc cctgccagcc agattcatag    12780

acaacatgac aaaccaggag gccagagaag gggccacggc cacactgcac tgtgaactga    12840

gcaaggtggc ccctgtggag tggaggaagg gacctgaaac cctccgagat ggggacagac    12900

acagcctgag gcaggatggg accaggtgtg agctgcagat tcgtggcctg tctgtggcag    12960

atgccgggga gtactcgtgc gtgtgtgggc aggagaggac ctcagccaca ctcacgatca    13020

gggaggccac agaaggggcc acggctatgt tgcagtgtga gctgagcaag gtggcccctg    13080

ttgagtggag gaagggacct gaaaccctca gagatgggga cagatacaac ctgaggcagg    13140

atgggaccag atgtgagctg cagattcatg gcctgtccgt ggcagacact ggggagtact    13200

catgtgtatg tggtcaggag aagacgtcgg ccactctcac tgtcaaggcc ccacagccag    13260

tgttccggga gccgctgcag agtctgcagg cggaggaggg ctccacggcc accctgcagt    13320

gtgagctgtc tgagcccact gctacagtgg tctggagcaa gggtggcctg cagctgcagg    13380

ccaatgggcg ccgggagcca cggcttcagg gctgcaccgc ggagctggtg ttacaggacc    13440

tacaacgtga agacactggc gaatacactt gcacctgtgg ctcccaggcc accagtgcca    13500

ccctcactgt cacagctgcg cctgtgcggt tcctccgaga gctgcagcac caggaggtgg    13560

atgagggagg caccgcacac ttatgctgcg agctgagccg ggcgggtgcg agcgtggagt    13620

ggcgcaaggg ctccctacag ctcttccctt gtgccaagta ccagatggtg caggatggtg    13680

cagctgcaga gctgctggta cgcggagtgg agcaggagga tgcgggtgac tacacgtgtg    13740

acacgggcca cacgcagagc atggccagcc tctctgtccg tgtccccagg cccaagttca    13800

agacccggct tcagagtctg gagcaggaga caggtgacat agcccggctg tgctgtcagc    13860

tgagtgatgc agagtcgggg gccgtggtgc aatggctcaa ggagggcgtg gagctgcatg    13920

cgggccccaa gtacgagatg cggagccagg gggccacgcg ggagctgctg atccaccaac    13980

tggaggccaa ggacacgggc gagtatgcct gtgtgacagg cggccagaaa accgctgcct    14040

ccctcagggt cacagagcct gaggtgacca ttgtacgggg gctggttgat gcggaggtga    14100

cggccgatga ggatgttgag ttcagctgtg aggtgtccag ggctggagcc acaggcgtgc    14160

agtggtgcct acagggcctg ccactgcaaa gcaatgaggt gacagaggtg gctgtgcggg    14220

atggccgcat ccacaccctg cggctgaagg gcgtgacgcc cgaggacgct ggcactgtct    14280

ccttccattt gggaaaccat gcttcctctg cccagctcac cgtcagagct cctgaggtga    14340

ccatcctgga gcccctgcag gacgtgcagc tcagtgaggg ccaggatgcc agcttccagt    14400

gccggctatc cagagcttca ggccaggagg cccgctgggc tttaggaggg gtgcccctgc    14460

aggccaacga gatgaatgac atcactgtgg agcagggcac actccacctg ctcaccctgc    14520

acaaggtgac ccttgaggat gctggaactg tcagtttcca cgtgggcacg tgtagctctg    14580

aggcccagct gaaagtcaca gccaagaaca cggtggtgcg ggggctggag aatgtggagg    14640

cgctggaggg cggcgaggcg ctgttcgagt gccagctgtc ccagcccgag gtggccgccc    14700

acacctggct gctggacgac gaacccgtgc acacctcgga gaacgccgag gtggtcttct    14760

tcgagaacgg cctgcgccac ctgctgctgc tcaaaaactt gcggccacaa gacagctgcc    14820

gggtgacctt cctggctggg gatatggtga cgtccgcatt cctcacggtc cgaggctggc    14880

gcctggagat cctggagcct ctgaaaaacg cggcggtccg ggccggcgca caggcatgct    14940

tcacctgcac gctcagcgag gcggtgcccg tgggagaggc gtcctggtac atcaatggcg    15000

cggcagtgca gccggatgac agcgactgga ctgtcaccgc cgacggcagt caccacgccc    15060

tactgctgcg cagcgcccag ccccaccacg ccggggaggt caccttcgct tgccgcgacg    15120

ccgtggcctc tgcgcggctc accgtgctgg gcctccctga tcccccagag gatgctgagg    15180

tggtggctcg cagcagccac actgtgacac tgtcttgggc agctcccatg agtgatggag    15240

gcggtggtct ctgtggctac cgcgtggagg tgaaggaggg ggccacaggc cagtggcggc    15300

tgtgccacga gctggtgcct ggacccgagt gtgtggtgga tggcctggcc cccggggaga    15360

cctaccgctt ccgtgtggca gctgtgggcc ctgtgggtgc tggggaaccg gttcacctgc    15420

cccagacagt gcggcttgca gagccaccga agcctgtgcc tccccagccc tcagcccctg    15480

agagccggca ggtggcagct ggtgaagatg tctctctgga gcttgaggtg gtggctgagg    15540

ctggtgaggt catctggcac aagggaatgg agcgcatcca gcccggtggg cggttcgagg    15600

tggtctccca gggtcggcaa cagatgctgg tgatcaaggg cttcacggca gaagaccagg    15660

gcgagtacca ctgtggcctg gctcagggct ccatctgccc tgcggctgcc accttccagg    15720

tggcactgag cccagcctct gtggatgagg cccctcagcc cagcttgccc cccgaggcag    15780

cccaggaggg tgacctgcac ctactgtggg aggccctggc tcggaaacgt cgcatgagcc    15840

gtgagcccac gctggactcc attagcgagc tgccagagga ggacggccgc tcgcagcgcc    15900

tgccacagga ggcagaggag gtggcacctg atctctctga aggctactcc acggccgatg    15960

agctggcccg cactggagat gctgacctct cacacaccag ctctgatgat gagtcccggg    16020

caggcacccc ttccctggtc acctacctca agaaggctgg gaggccaggc acctcaccac    16080

tggccagcaa ggttggggcc ccagcagccc cctctgtgaa gccacagcag cagcaggagc    16140

cactggctgc tgtgcgccca ccactgggag acctgagcac caaagacctg ggtgatccct    16200

caatggacaa ggcagctgtg aagatccagg ctgcctttaa gggctacaag gtccggaagg    16260

agatgaagca gcaggaaggg cccatgttct cccacacatt tggggacacc gaggcacagg    16320

tgggggatgc cctgcggctg gagtgtgtcg tggccagcaa ggcagatgtg cgagcccgct    16380

ggctgaagga tggtgtggag ctgaccgatg ggcggcacca tcacatcgac cagcttgggg    16440

atggcacctg ctctctgctg atcactggcc tggaccgtgc tgatgctggc tgctacacct    16500

gtcaggtgag caacaagttt ggccaggtga cccacagtgc ctgtgtggtg gtcagtgggt    16560

cagagagtga agccgagagc tcctctgggg gtgagctgga cgatgccttc cgccgggctg    16620

cccgtcggct gcaccggctc ttccgcacca aaagtccggc tgaagtttca gatgaggagc    16680

tcttcctgag tgcagacgag ggccctgcag agccagagga gcccgcggac tggcagacat    16740

accgcgaaga tgagcatttc atctgcatcc gttttgaggc gctcactgag gcccgccagg    16800

cggtaactcg cttccaggag atgtttgcca cactgggcat tggggtggag atcaagctgg    16860

tggaacaggg gcctcggagg gtagagatgt gcatcagcaa agagactcct gcccctgtgg    16920

tgcctccaga gccattgccc agcctactga cttctgacgc tgccccagtg ttcctgactg    16980

agttgcagaa ccaagaagtg caggatgggt atcctgtgag ctttgactgc gtggtgacag    17040

gtcagcccat gcccagtgtg cgctggttca aggatgggaa gttgttggag gaggatgatc    17100

actacatgat taatgaagac caacagggtg gccatcagct catcatcaca gccgtggtgc    17160

cagcagacat gggcgtctac cgctgcctgg ccgagaacag catgggtgtc tcctccacca    17220

aggctgagct ccgtgtggac ttgacaagca cagactatga cactgcagca gatgccacgg    17280

agtcctcatc ctacttcagt gcccaaggct acctgtccag ccgggagcag gagggaacag    17340

agtccaccac tgatgagggc cagctgcccc aggtggtgga ggagctgaga gacctccagg    17400

tggcccctgg cacacgcctg gccaagttcc agctcaaggt gaaaggctac cctgctccca    17460

gattatactg gttcaaagat ggccagcccc tgaccgcatc tgcccacatc cgcatgactg    17520

acaagaagat cctgcacacc ctggagatca tctccgtcac ccgggaggac tctggccagt    17580

atgcagccta tatcagcaat gccatgggtg ctgcctactc gtctgcccgg ctgctggttc    17640

gaggccctga tgagccagaa gagaagcctg catcagatgt gcatgagcag ctggtgccgc    17700

cccgaatgct ggagaggttc acccccaaga aagtgaagaa aggctccagc atcaccttct    17760

ctgtgaaggt agaaggacgc ccggtgccca ccgtgcactg gctcagggag gaggctgaga    17820

gaggcgtgct gtggattggc cctgacacac cgggctacac cgtggccagc tctgcgcagc    17880

agcacagcct ggtcctgctg gacgtgggcc ggcagcacca gggcacctac acatgcattg    17940

ccagcaacgc tgccggccag gccctctgct ccgccagcct gcacgtctcg ggcctgccta    18000

aggtggagga gcaggagaaa gtgaaggaag cgctgatttc cactttcctg caggggacca    18060

cacaagccat ctcagcacag gggttggaaa ctgcgagttt tgctgacctt ggtgggcaga    18120

ggaaagaaga gcctctggct gccaaggagg ccctcggcca cctgtccctc gctgaggtgg    18180

gcacagagga gttcctgcag aaactgacct cccagatcac tgagatggta tcggccaaga    18240

tcacgcaggc caagctgcag gtgcccggag gtgacagtga tgaggactcc aagacaccat    18300

ctgcatcccc ccgccatggc cgatcacggc catcctccag catccaggag tcttcctcag    18360

agtcagagga cggcgatgcc cgaggcgaga tctttgacat ctacgtggtc accgctgact    18420

acctgcccct aggggctgag caggatgcca tcacgctgcg ggaaggccag tatgtggagg    18480

tcctggatgc agcccaccca ctgcgctggc ttgtccgcac caagcccacc aagtccagcc    18540

cctcacggca gggctgggtg tcaccagcct acctggacag gaggctcaag ctgtcacctg    18600

agtggggggc cgctgaggcc cctgagttcc ctggggaggc tgtgtctgaa gacgaataca    18660

aggcaaggct gagctctgtg atccaggagc tgctgagttc tgagcaggcc ttcgtggagg    18720

agctgcagtt cctgcagagc caccacctgc agcacctgga gcgctgcccc cacgtgccca    18780

tagctgtggc cggccagaag gcagtcatct tccgcaatgt gcgggacatc ggccgcttcc    18840

acagcagctt cctgcaggag ttgcagcagt gcgacacgga cgacgacgtg gccatgtgct    18900

tcatcaagaa ccaggcggcc tttgagcagt acctggagtt cctggtgggg cgtgtgcagg    18960

ctgagtcggt ggtcgtcagc acggccatcc aggagttcta caagaaatac gcggaggagg    19020

ccctgttggc aggggacccc tctcagcccc cgccaccacc tctgcagcac tacctggagc    19080

agccagtgga gcgggtgcag cgctaccagg ccttgctgaa ggagctgatc cgcaacaagg    19140

cgcggaacag acagaactgc gcgctgctgg agcaggccta tgccgtggtg tctgccctgc    19200

cacagcgcgc tgagaacaag ctgcacgtgt ccctcatgga gaactaccca ggcaccctgc    19260

aggccctggg cgagcccatc cgccagggcc acttcatcgt gtgggagggt gcaccggggg    19320

cccgcatgcc ctggaagggc cacaaccgtc acgtgttcct cttccgcaac cacctggtaa    19380

tctgcaagcc ccggcgagac tcccgcaccg ataccgtcag ctacgtgttc cggaacatga    19440

tgaagctgag cagcatcgac ctgaacgacc aggtggaggg ggatgaccgc gccttcgagg    19500

tgtggcagga gcgggaggac tcggtgcgca agtacctgct gcaggcacgg acagccatta    19560

tcaagagctc gtgggtgaag gagatctgtg gcatccagca gcgtctggcc ctgcctgtgt    19620

ggcggccccc ggactttgaa gaggagctgg ccgactgcac agccgagctg ggtgagacag    19680

tcaagctggc ctgccgcgtg acgggcacac ccaagcctgt catcagctgg tacaaagatg    19740

ggaaagcagt gcaggtggac ccccaccaca tcctcattga agaccctgat ggctcgtgtg    19800

cactcatcct ggacagcctg accggtgtgg actctggcca gtacatgtgc ttcgcggcca    19860

gcgccgctgg caactgcagt accctgggca agatcctggt gcaagtccca ccacggttcg    19920

tgaacaaggt ccgggcctca ccctttgtgg agggagagga cgcccagttc acctgcacca    19980

tcgaaggcgc cccgtacccg cagatcaggt ggtacaagga cggggccctg ctgaccactg    20040

gcaacaagtt ccagacactg agtgagcctc gcagcggcct gctagtgctg gtgatccggg    20100

cggccagcaa ggaggacctg gggctctacg agtgtgagct ggtgaaccgg ctgggctccg    20160

cgcgggctag tgcggagctg cgcattcaga gccccatgct gcaggcccag gagcagtgtc    20220

acagggagca gctcgtggct gcagtggaag acaccaccct ggagcgagcg gaccaggagg    20280

tcacatctgt cctgaagaga ctgctgggcc ccaaggcgcc aggcccctcc acaggggacc    20340

tcactggccc tggcccctgc cccagggggg cacccgcact ccaggaaacc ggctcccagc    20400

ccccagtcac cggaacttcg gaggcacctg ccgtgccccc gagggtgcca cagcccctcc    20460

tccacgaagg cccagagcag gagccggagg ccattgccag agcccaggaa tggactgtgc    20520

ccattcggat ggagggtgca gcctggcccg gggcaggcac aggggagctg ctctgggacg    20580

tccacagcca cgtggtcaga gagaccacac agaggaccta cacataccag gccatcgaca    20640

cgcacaccgc acggccccca tccatgcagg taaccatcga ggatgtgcag gcacagacag    20700

gcggaacggc ccaattcgag gctatcattg agggcgaccc acagccctcg gtgacctggt    20760

acaaggacag cgtccagctg gtggacagca cccggcttag ccagcagcaa gaaggcacca    20820

catactccct ggtgctgagg catgtggcct cgaaggatgc cggcgtttac acctgcctgg    20880

cccaaaacac tggtggccag gtgctctgca aggcagagct gctggtgctt gggggggaca    20940

atgagccgga ctcagagaag caaagccacc ggaggaagct gcactccttc tatgaggtca    21000

aggaggagat tggaaggggc gtgtttggct tcgtaaaaag agtgcagcac aaaggaaaca    21060

agatcttgtg cgctgccaag ttcatccccc tacggagcag aactcgggcc caggcataca    21120

gggagcgaga catcctggcc gcgctgagcc acccgctggt cacggggctg ctggaccagt    21180

ttgagacccg caagaccctc atcctcatcc tggagctgtg ctcatccgag gagctgctgg    21240

accgcctgta caggaagggc gtggtgacgg aggccgaggt caaggtctac atccagcagc    21300

tggtggaggg gctgcactac ctgcacagcc atggcgttct ccacctggac ataaagccct    21360

ctaacatcct gatggtgcat cctgcccggg aagacattaa aatctgcgac tttggctttg    21420

cccagaacat caccccagca gagctgcagt tcagccagta cggctcccct gagttcgtct    21480

cccccgagat catccagcag aaccctgtga gcgaagcctc cgacatttgg gccatgggtg    21540

tcatctccta cctcagcctg acctgctcat ccccatttgc cggcgagagt gaccgtgcca    21600

ccctcctgaa cgtcctggag gggcgcgtgt catggagcag ccccatggct gcccacctca    21660

gcgaagacgc caaagacttc atcaaggcta cgctgcagag agcccctcag gcccggccta    21720

gtgcggccca gtgcctctcc cacccctggt tcctgaaatc catgcctgcg gaggaggccc    21780

acttcatcaa caccaagcag ctcaagttcc tcctggcccg aagtcgctgg cagcgttccc    21840

tgatgagcta caagtccatc ctggtgatgc gctccatccc tgagctgctg cggggcccac    21900

ccgacagccc ctccctcggc gtagcccggc acctctgcag ggacactggt ggctcctcca    21960

gttcctcctc ctcctctgac aacgagctcg ccccatttgc ccgggctaag tcactgccac    22020

cctccccggt gacacactca ccactgctgc acccccgggg cttcctgcgg ccctcggcca    22080

gcctgcctga ggaagccgag gccagtgagc gctccaccga ggccccagct ccgcctgcat    22140

ctcccgaggg tgccgggcca ccggccgccc agggctgcgt gccccggcac agcgtcatcc    22200

gcagcctgtt ctaccaccag gcgggtgaga gccctgagca cggggccctg gccccgggga    22260

gcaggcggca cccggcccgg cggcggcacc tgctgaaggg cgggtacatt gcgggggcgc    22320

tgccaggcct gcgcgagcca ctgatggagc accgcgtgct ggaggaggag gccgccaggg    22380

aggagcaggc caccctcctg gccaaagccc cctcattcga gactgccctc cggctgcctg    22440

cctctggcac ccacttggcc cctggccaca gccactccct ggaacatgac tctccgagca    22500

ccccccgccc ctcctcggag gcctgcggtg aggcacagcg actgccttca gccccctccg    22560

ggggggcccc tatcagggac atggggcacc ctcagggctc caagcagctt ccatccactg    22620

gtggccaccc aggcactgct cagccagaga ggccatcccc ggacagccct tgggggcagc    22680

cagccccttt ctgccacccc aagcagggtt ctgcccccca ggagggctgc agcccccacc    22740

cagcagttgc cccatgccct cctggctcct tccctccagg atcttgcaaa gaggccccct    22800

tagtaccctc aagccccttc ttgggacagc cccaggcacc ccctgcccct gccaaagcaa    22860

gccccccatt ggactctaag atggggcctg gagacatctc tcttcctggg aggccaaaac    22920

ccggcccctg cagttcccca gggtcagcct cccaggcgag ctcttcccaa gtgagctccc    22980

tcagggtggg ctcctcccag gtgggcacag agcctggccc ctccctggat gcggagggct    23040

ggacccagga ggctgaggat ctgtccgact ccacacccac cttgcagcgg cctcaggaac    23100

aggcgaccat gcgcaagttc tccctgggtg gtcgcggggg ctacgcaggc gtggctggct    23160

atggcacctt tgcctttggt ggagatgcag ggggcatgct ggggcagggg cccatgtggg    23220

ccaggatagc ctgggctgtg tcccagtcag aggaggagga gcaggaggag gccagggctg    23280

agtcccagtc ggaggagcag caggaggcca gggctgagag cccactgccc caggtcagtg    23340

caaggcctgt gcctgaggtc ggcagggctc ccaccaggag ctctccagag cccaccccat    23400

gggaggacat cgggcaggtc tccctggtgc agatccggga cctgtcaggt gatgcggagg    23460

cggccgacac aatatccctg gacatttccg aggtggaccc cgcctacctc aacctctcag    23520

acctgtacga tatcaagtac ctcccattcg agtttatgat cttcaggaaa gtccccaagt    23580

ccgctcagcc agagccgccc tcccccatgg ctgaggagga gctggccgag ttcccggagc    23640

ccacgtggcc ctggccaggt gaactgggcc cccacgcagg cctggagatc acagaggagt    23700

cagaggatgt ggacgcgctg ctggcagagg ctgccgtggg caggaagcgc aagtggtcct    23760

cgccgtcacg cagcctcttc cacttccctg ggaggcacct gccgctggat gagcctgcag    23820

agctggggct gcgtgagaga gtgaaggcct ccgtggagca catctcccgg atcctgaagg    23880

gcaggccgga aggtctggag aaggaggggc cccccaggaa gaagccaggc cttgcttcct    23940

tccggctctc aggtctgaag agctgggacc gagcgccgac attcctaagg gagctctcag    24000

atgagactgt ggtcctgggc cagtcagtga cactggcctg ccaggtgtca gcccagccag    24060

ctgcccaggc cacctggagc aaagacggag cccccctgga gagcagcagc cgtgtcctca    24120

tctctgccac cctcaagaac ttccagcttc tgaccatcct ggtggtggtg gctgaggacc    24180

tgggtgtgta cacctgcagc gtgagcaatg cgctggggac agtgaccacc acgggcgtcc    24240

tccggaaggc agagcgcccc tcatcttcgc catgcccgga tatcggggag gtgtacgcgg    24300

atggggtgct gctggtctgg aagcccgtgg aatcctacgg ccctgtgacc tacattgtgc    24360

agtgcagcct agaaggcggc agctggacca cactggcctc cgacatcttt gactgctgct    24420

acctgaccag caagctctcc cggggtggca cctacacctt ccgcacggca tgtgtcagca    24480

aggcaggaat gggtccctac agcagcccct cggagcaagt cctcctggga gggcccagcc    24540

acctggcctc tgaggaggag agccaggggc ggtcagccca acccctgccc agcacaaaga    24600

ccttcgcatt ccagacacag atccagaggg gccgcttcag cgtggtgcgg caatgctggg    24660

agaaggccag cgggcgggcg ctggccgcca agatcatccc ctaccacccc aaggacaaga    24720

cagcagtgct gcgcgaatac gaggccctca agggcctgcg ccacccgcac ctggcccagc    24780

tgcacgcagc ctacctcagc ccccggcacc tggtgctcat cttggagctg tgctctgggc    24840

ccgagctgct cccctgcctg gccgagaggg cctcctactc agaatccgag gtgaaggact    24900

acctgtggca gatgttgagt gccacccagt acctgcacaa ccagcacatc ctgcacctgg    24960

acctgaggtc cgagaacatg atcatcaccg aatacaacct gctcaaggtc gtggacctgg    25020

gcaatgcaca gagcctcagc caggagaagg tgctgccctc agacaagttc aaggactacc    25080

tagagaccat ggctccagag ctcctggagg gccagggggc tgttccacag acagacatct    25140

gggccatcgg tgtgacagcc ttcatcatgc tgagcgccga gtacccggtg agcagcgagg    25200

gtgcacgcga cctgcagaga ggactgcgca aggggctggt ccggctgagc cgctgctacg    25260

cggggctgtc cgggggcgcc gtggccttcc tgcgcagcac tctgtgcgcc cagccctggg    25320

gccggccctg cgcgtccagc tgcctgcagt gcccgtggct aacagaggag ggcccggcct    25380

gttcgcggcc cgcgcccgtg accttcccta ccgcgcggct gcgcgtcttc gtgcgcaatc    25440

gcgagaagag acgcgcgctg ctgtacaaga ggcacaacct ggcccaggtg cgctgagggt    25500

cgccccggcc acacccttgg tctccccgct gggggtcgct gcagacgcgc caataaaaac    25560

gcacagccgg gcgag                                                     25575


<210> 1560
<211> 19907
<212> DNA
<213> Homo sapiens

<400> 1560
gctgcccaga gcccccatag agagaggtcc ccgccgccac cctcatggat cagccacagt       60

tcagcggggc gccccgcttt ctcacccggc ccaaggcctt cgtggtgtcg gtgggcaagg      120

acgccaccct cagctgccag atcgtgggta atcccacgcc acaggtgagc tgggagaagg      180

accagcagcc ggtggcggcc ggcgcgcgct tccgtctggc ccaggacggc gacctctacc      240

gcctcactat cctggacctg gcgctgggcg acagtgggca atacgtgtgc cgcgcgcgca      300

atgccatagg cgaggccttc gctgctgtgg gcctgcaggt ggacgcggag gccgcgtgcg      360

ccgagcaggc gccgcacttc ctgctgcggc ccacgtccat ccgcgtgcgc gagggctcag      420

aggccacctt ccgctgccgc gtgggtggct ccccgaggcc ggcagtgagc tggtccaagg      480

acgggcggcg cctgggtgag cccgacggcc cccgcgtgcg cgtggaggag ctcggcgagg      540

caagtgcgct gcgcattcgg gcggcgcggc cgcgcgacgg cggcacttac gaggtccgcg      600

ccgagaaccc gctgggcgct gccagcgccg ccgcggcgct agtggtggac tcggacgccg      660

cggacacggc cagccggccc gggacctcca cggccgcgct cctggcgcac ctgcagcggc      720

ggcgcgaggc tatgcgcgcc gagggcgccc ccgcctcacc gcccagcacc ggcacgcgca      780

cctgcacggt gactgaaggc aagcacgcgc gcctcagctg ctacgtgacc ggcgagccca      840

agcccgagac ggtgtggaag aaggacggcc agctggtgac cgagggccgg cgccacgtgg      900

tgtacgagga cgcgcaggag aacttcgtgc tcaagatcct cttctgcaag cagtcggacc      960

gcggcctcta cacctgcacg gcgtccaacc tcgtgggcca gacctacagc tctgtgctgg     1020

tcgtagtgcg cgagcccgcg gttcccttca aaaagcggct gcaagatctg gaggtgcggg     1080

agaaggagtc ggccacgttc ctatgtgagg tgccccagcc gtccactgag gccgcgtggt     1140

tcaaggagga gacgcggttg tgggcgagcg ccaagtacgg catcgaggag gagggcaccg     1200

agcgccgcct gaccgtgcgc aatgtctcgg ccgacgacga cgcggtgtac atctgcgaga     1260

cgccagaggg cagccgcacg gtggcggagc tcgcagtcca aggaaacctc ctccgaaagc     1320

tccctcggaa gacggcggtg cgcgtgggcg acacggctat gttttgcgtg gagctggcgg     1380

tcccggtggg ccccgtccac tggctgcgga accaggagga agtggtggcg gggggccgcg     1440

tggccatctc cgcggagggc acgcgccaca cactaaccat ctcccagtgc tgcctggagg     1500

atgtgggcca ggtggccttt atggctggcg actgccagac gtccacccag ttctgcgtgt     1560

cggcccccag gaagcctccc ctgcaacccc ctgtggatcc tgtggtaaag gccaggatgg     1620

agagttccgt gattctcagc tggtccccac caccccatgg ggaacgccct gtcactatcg     1680

acggctacct ggtagagaag aagaagcttg gcacctacac ctggatcagg tgccacgagg     1740

ctgaatgggt ggctacacct gagctgaccg tggctgatgt ggcggaggag gggaacttcc     1800

agttccgagt gtccgctctc aacagctttg gtcagagtcc ctacctcgag ttcccgggga     1860

ctgtccacct ggcccccaag ctggccgtga ggacaccgct gaaggcggtg caggcggtag     1920

agggtggcga ggtcactttc tccgtggacc tcacggtggc ctcagcgggt gagtggttcc     1980

tggatgggca ggccctgaag gccagcagtg tgtatgagat ccactgtgat cgcacccggc     2040

acacgctcac catccgggag gtgcccgcca gcctgcacgg ggcgcagctg aagttcgtgg     2100

ccaacggcat tgagagcagc atccggatgg aggtccgggc ggccccaggg ctgactgcca     2160

acaagccgcc agccgcagct gcccgggagg tgctggctcg gctgcacgag gaggcgcagc     2220

tgctggctga gctgtcagat caggctgcgg ctgtgacgtg gctgaaggat ggtcgcacac     2280

tgtccccagg ccccaagtat gaggtgcagg catcggccgg gcggcgggtg ctccttgtgc     2340

gagatgtggc ccgggacgat gcaggcctct acgagtgcgt cagccgcggg ggccgcatcg     2400

cctaccagct ctccgtgcaa ggcctcgcgc gctttctgca caaggacatg gcgggcagct     2460

gtgtggatgc cgtggctggg ggcccggcgc agtttgagtg tgagacctcc gaagcccacg     2520

tccacgtgca ctggtacaag gatggcatgg agctgggcca ctccggtgag cgcttcttgc     2580

aggaggatgt ggggacgcgg caccggctgg tggcagccac agtcaccagg caggatgaag     2640

gcacctactc ctgccgcgtg ggcgaggact ctgtggactt ccggctccgc gtctctgagc     2700

ccaaggtggt gtttgctaag gagcagctgg cacgcaggaa gctgcaggca gaggcaggag     2760

ccagtgccac actgagctgc gaggtggccc aggcccagac ggaggtgacg tggtacaagg     2820

atgggaagaa gctgagctcc agctcgaaag tgtgcatgga ggccacaggc tgcacgcgca     2880

ggctggttgt gcagcaggca ggccaggcgg atgccgggga gtatagctgc gaggctgggg     2940

gccagcggct ctccttccat ctggatgtca aagagcccaa ggtggtgttt gccaaggacc     3000

aggtggcaca cagtgaggtg caggctgagg caggggccag tgccacgctg agctgcgagg     3060

tggcccaggc ccagacggag gtgatgtggt acaaagatgg gaagaagctg agctccagct     3120

tgaaagtgca tgtagaggcc aagggctgca gacggaggct ggtggtgcag caggcaggca     3180

agacagatgc cggggactac agctgcgagg ccaggggcca gagggtctcc ttccgcctgc     3240

acatcacaga gcccaagatg atgtttgcaa aggagcagtc agtgcataat gaggtgcagg     3300

ctgaggcggg ggccagtgcc atgctgagct gtgaggtggc ccaggcccag acggaggtga     3360

cgtggtacaa ggatgggaag aagctgagct ccagctcaaa agtgggcatg gaggtcaaag     3420

ggtgcacacg gaggctggtg ctgccacagg cgggcaaagc agatgctggg gagtacagct     3480

gtgaggctgg gggccagaga gtctccttcc acctgcacat cacagagccc aagggggtgt     3540

ttgcgaagga gcagtcagtg cataatgagg tgcaggctga ggcggggacc actgccatgc     3600

tgagctgtga ggtggcccag ccccagacag aggtgacgtg gtacaaggac gggaagaagc     3660

tgagctccag ctcaaaagta cgcatggagg tcaagggctg cacacgaagg ctggtagtgc     3720

agcaggtggg caaagcagat gctggggagt acagctgcga ggctgggggc cagagagtct     3780

cctttcaact gcacatcaca gagcccaagg cagtgtttgc caaggagcag ttggtgcata     3840

atgaggtgcg gactgaggca ggggccagtg ccacactgag ctgtgaggtg gcccaggccc     3900

agacagaggt gacgtggtac aaggatggga agaagctgag ctccagttcg aaagtgcgca     3960

tagaggctgc gggctgcatg cggcagctgg tggtgcagca ggcaggccag gcagatgctg     4020

gggagtacac ctgtgaggct gggggccagc ggctctcctt ccacctggat gtttcagagc     4080

ccaaggcggt gtttgcaaag gagcagctgg cacacaggaa ggtgcaggcc gaggcggggg     4140

ccattgccac gctgagctgc gaggtggccc aggcccagac agaggtgacg tggtacaagg     4200

acgggaagaa gctgagctcc agctcgaaag ttcgaatgga ggctgtgggc tgcacacgga     4260

ggctggtggt gcagcaggca tgccaggcgg acaccgggga gtatagctgc gaggccgggg     4320

gccagcggct ctccttcagc ctggacgtgg cagagcccaa ggtggtgttt gccaaggagc     4380

agccagtgca cagggaggtg caggcccagg cgggggccag caccacactc agctgcgagg     4440

tggctcaggc ccagacggag gtgatgtggt acaaggacgg gaagaagctg agcttcagct     4500

cgaaagtgcg catggaggct gtgggctgca cacggaggct ggtggtgcag caggcgggcc     4560

aggcggtcgc cggggagtac agctgcgagg cggggagcca gcggctctcc ttccacctgc     4620

acgtggcaga gcccaaggcg gtgtttgcca aggagcagcc agcgagcagg gaggtgcagg     4680

ctgaggcggg gaccagtgcc acgctgagct gcgaggtggc ccaggcccag acagaggtga     4740

cgtggtacaa ggacgggaag aaactgagct ccagctcgaa agtgcgaatg gaggccgtgg     4800

gctgcacacg gaggctggtg gtgcaggagg caggccaggc ggacgccggg gagtacagct     4860

gcaaggccgg ggatcagcgg ctgtccttcc acctgcacgt ggcagagccc aaggtggtgt     4920

ttgccaagga gcagccagca cacagggagg tgcaggctga ggcgggggcc agtgccacgc     4980

tgagctgcga ggtggcccag gcccagacag aggtgacgtg gtacaaggat gggaagaagc     5040

tgagttccag ctcgaaagtg cgcgtggagg ccgtgggctg cacacggagg ctggtggtgc     5100

agcaggcggg ccaggcagag gccggggagt acagctgcga ggcagggggt cagcagctct     5160

ccttccgcct gcaggtggca gagctggagc cccaaatttc agagagaccc tgccgcaggg     5220

agcctctggt ggtcaaggag catgaagaca tcatcctgac cgccacactg gccacaccct     5280

ctgcggccac ggtgacctgg ctcaaggatg gtgtggagat tcgccgcagc aagcggcatg     5340

agacagccag ccagggggac acccacaccc tgaccgtgca tggcgcccag gttctggaca     5400

gcgccatcta cagctgccgt gtgggcgcag aggggcagga cttcccagtg caggtggaag     5460

aggtggccgc caagttctgc cggctgctgg agcctgtgtg cggcgagctg ggtggcacgg     5520

tgacactggc ctgcgagcta agcccagcgt gtgcagaggt ggtgtggcgc tgcggcaaca     5580

cgcagcttcg ggtgggcaag cgcttccaga tggtggccga ggggcccgtg cgctcactca     5640

ctgtgttggg gctgcgcgca gaggacgcag gggagtacgt gtgtgagagc cgtgatgacc     5700

acaccagtgc gcagctcacc gtcagtgtgc cccgagtggt gaagtttatg tctgggctga     5760

gcaccgtggt cgcagaggag ggcggcgagg ccaccttcca gtgcgtggtg tcccccagtg     5820

atgtggcagt cgtgtggttc cgggacggtg ccctgcttca gcccagcgag aagtttgcca     5880

tatcacagag tggcgccagc cacagcctga ccatctcaga cctggtgctg gaggacgcgg     5940

gccagatcac cgtggaggct gagggcgcct catcctctgc tgccctgagg gtccgagagg     6000

cgcctgtgct gttcaaaaag aagctggagc cgcagacggt ggaggagcgg agctcggtga     6060

ccctggaggt ggagctgacg cggccgtggc cggagctgag gtggacacgg aacgcgacgg     6120

ccctggcgcc gggaaagaac gtggagatcc acgccgaggg cgcccgccac cgcctggttc     6180

tgcacaacgt aggttttgcc gaccgtggct tctttggctg cgagacgccg gatgacaaga     6240

cacaggccaa actcaccgtg gagatgcgcc aggtacggct cgtacggggc ctgcaggcag     6300

tggaggcacg ggagcagggc acggctacca tggaggtgca gctgtcgcat gcggacgtgg     6360

atggcagctg gactcgtgac ggtctgcggt tccagcaggg gcccacgtgc cacctggctg     6420

tgcggggccc catgcacacc ctcacactct cggggctgcg gccagaggat agtggcctta     6480

tggtcttcaa ggccgaagga gtgcacacgt cggcgcggct cgtggtcacc gagcttcccg     6540

tgagcttcag ccgcccgctg caggacgtgg tgaccactga gaaggagaag gttaccctgg     6600

agtgcgagct gtcgcgtcct aatgtggatg tgcgctggct gaaggacggt gtggagctgc     6660

gggcaggcaa gacgatggcc atcgcagccc agggcgcctg caggagcctc accatttacc     6720

ggtgcgagtt cgcggatcag ggagtgtatg tgtgtgatgc ccatgatgcc cagagctctg     6780

cctccgtgaa ggtacaagga aggacataca ctctcatcta ccggagagtc ctggcggaag     6840

atgcaggaga gatccaattt gtagccgaaa atgcagaatc gcgagcccag ctccgagtga     6900

aggagctgcc agtgaccctc gtgcgcccgc tgcgggacaa gattgccatg gagaagcacc     6960

gcggtgtgct ggagtgtcag gtgtcccggg ccagcgccca ggtgcggtgg ttcaagggca     7020

gtcaggagct gcagcccggg cccaagtacg agctggtcag tgatggcctc taccgcaagc     7080

tgatcatcag tgatgtccac gcagaggacg aggacaccta cacctgtgac gccggtgatg     7140

tcaagaccag tgcacagttc ttcgtggaag agcaatccat caccattgtg cggggtctgc     7200

aggacgtgac agtgatggag cccgctcctg cctggtttga gtgtgagacc tccatcccct     7260

cagtgcggcc acctaagtgg ctcctgggga agacggtgtt gcaggctggg gggaacgtgg     7320

gcctggagca ggagggcacg gtgcaccggc tgatgctgcg gcggacctgc tccaccatga     7380

ccgggcccgt gcacttcacc gttggcaagt cgcgctcctc tgcccgcctg gtggtctcag     7440

acatccccgt agtcctcaca cggccgttgg agcccaagac agggcgtgag ctgcagtcag     7500

tggtcctgtc ctgcgacttc cggccagccc ccaaggctgt gcagtggtac aaggatgaca     7560

cgcccctgtc tccctctgag aagtttaaga tgagcctgga gggtcagatg gctgagctgc     7620

gcatcctccg gctcatgcct gctgatgctg gtgtctaccg gtgccaggcg ggcagtgccc     7680

acagcagcac tgaggtcact gtggaagcgc gggaggtgac agtgacaggg ccgctacagg     7740

atgcagaggc cacggaggag ggctgggcca gcttctcctg tgagctgtcc cacgaggatg     7800

aggaggtcga gtggtcgctc aacgggatgc ccctgtacaa cgacagcttc catgagatct     7860

cacacaaggg ccggcgccac acgctggtac tgaagagcat ccagcgggct gatgcgggca     7920

tagtacgcgc ctcctccctg aaggtgtcga cctctgcccg cctggaggtc cgagtgaagc     7980

cggtggtgtt cctgaaggcg ctggatgacc tgtccgcaga ggagcgcggc accctggccc     8040

tgcagtgtga agtctctgac cccgaggccc atgtggtgtg gcgcaaagat ggcgtgcagc     8100

tgggccccag tgacaagtat gacttcctgc acacggcggg cacgcggggg ctcgtggtgc     8160

atgacgtgag ccctgaagac gccggcctgt acacctgcca cgtgggctcc gaggagaccc     8220

gggcccgggt ccgcgtgcac gatctgcacg tgggcatcac caagaggctg aagacaatgg     8280

aggtgctgga aggggaaagc tgcagctttg agtgcgtcct gtcccacgag agtgccagcg     8340

acccggccat gtggacagtc ggtgggaaga cagtgggcag ctccagccgc ttccaggcca     8400

cacgtcaggg ccgaaaatac atcctggtgg tccgggaggc tgcaccaagt gatgccgggg     8460

aggtggtctt ctctgtgcgg ggcctcacct ccaaggcctc actcattgtc agagagaggc     8520

cggccgccat catcaagccc ctggaagacc agtgggtggc gccaggggag gacgtggagc     8580

tgcgctgtga gctgtcacgg gcgggaacgc ccgtgcactg gctgaaggac aggaaggcca     8640

tccgcaagag ccagaagtat gatgtggtct gcgagggcac gatggccatg ctggtcatcc     8700

gcggggcctc gctcaaggac gcgggcgagt acacgtgtga ggtggaggct tccaagagca     8760

cagccagcct ccatgtggaa gaaaaagcaa actgcttcac agaggagctg accaatctgc     8820

aggtggagga gaaaggcaca gctgtgttca cgtgcaagac ggagcacccc gcggccacag     8880

tgacctggcg caagggcctc ttggagctac gggcctcagg gaagcaccag cccagccagg     8940

agggcctgac cctgcggctc accatcagtg ccctggagaa ggcagacagc gacacctata     9000

cctgcgacat tggccaggcc cagtcccggg cccagctcct agtgcaaggc cggagagtgc     9060

acatcatcga ggacctggag gatgtggatg tgcaggaggg ctcctcggcc accttccgtt     9120

gccggatctc cccggccaac tacgagcctg tgcactggtt cctggacaag acacccctgc     9180

atgccaacga gctcaatgag atcgatgccc agcccggggg ctaccacgtg ctgaccctgc     9240

ggcagctggc gctcaaggac tcgggcacca tctactttga ggcgggtgac cagcgggcct     9300

cggccgccct gcgggtcact gagaagccaa gcgtcttctc ccgggagctc acagatgcca     9360

ccatcacaga gggtgaggac ttgaccctgg tgtgcgagac cagcacctgc gacattcctg     9420

tgtgctggac caaggatggg aagaccctgc gggggtctgc ccggtgccag ctgagccatg     9480

agggccaccg ggcccagctg ctcatcactg gggccaccct gcaggacagt ggacgctaca     9540

agtgtgaggc tgggggcgcc tgcagcagct ccattgtcag ggtgcatgcg cggccagtgc     9600

ggttccagga ggccctgaag gacctggagg tgctggaggg tggtgctgcc acactgcgct     9660

gtgtgctgtc atctgtggct gcgcccgtga agtggtgcta tggaaacaac gtcctgaggc     9720

caggtgacaa atacagccta cgccaggagg gtgccatgct ggagctggtg gtccggaacc     9780

tccggccgca ggacagcggg cggtactcat gctccttcgg ggaccagact acttctgcca     9840

ccctcacagt gactgccctg cctgcccagt tcatcgggaa actgagaaac aaggaggcca     9900

cagaaggggc cacggccacg ctgcggtgtg agctgagcaa ggcagcccct gtggagtgga     9960

gaaaggggtc cgagaccctc agagatgggg acagatactg tctgaggcag gacggggcca    10020

tgtgtgagct gcagatccgt ggcctggcca tggtggatgc cgcggagtac tcgtgtgtgt    10080

gtggagagga gaggacctca gcctcactca ccatcaggcc catgcctgcc cacttcatag    10140

gaagactgag acaccaagag agcatagaag gggccacagc cacgctgcgg tgtgagctga    10200

gcaaggcggc ccccgtggag tggaggaagg ggcgtgagag cctcagagat ggggacagac    10260

atagcctgag gcaggacggg gctgtgtgcg agctgcagat ctgtggcctg gctgtggcag    10320

atgctgggga gtactcctgt gtgtgtgggg aggagaggac ctctgccact ctcaccgtga    10380

aggccctgcc agccaagttc acagagggtc tgaggaatga agaggccgtg gaaggggcca    10440

cagccatgtt gtggtgtgaa ctgagcaagg tggcccctgt ggagtggagg aaggggcccg    10500

agaacctcag agatggggac agatacatcc tgaggcagga ggggaccagg tgtgagctgc    10560

agatctgtgg cctggccatg gcggacgccg gggagtactt gtgtgtgtgc gggcaggaga    10620

ggacctcagc cacgctcacc atcagggctc tgcctgccag gttcatagaa gatgtgaaaa    10680

accaggaggc cagagaaggg gccacagctg tgctgcagtg tgagctgaac agtgcagccc    10740

ctgtggagtg gagaaagggg tctgagaccc ttagagatgg ggacagatac agcctgaggc    10800

aggacgggac taaatgtgag ctgcagattc gtggcctggc catggcagac actggggagt    10860

actcgtgcgt gtgcgggcag gagaggacct cggctatgct caccgtcagg gctctaccca    10920

tcaagttcac agagggtctg aggaacgaag aggccacaga aggggcaaca gccgtgctgc    10980

ggtgtgagct gagcaagatg gcccccgtgg agtggtggaa ggggcatgag accctcagag    11040

atggagacag acacagcctg aggcaggacg gggccaggtg tgagctgcag atccgcggcc    11100

tcgtggcaga ggacgctggg gagtacctgt gcatgtgcgg gaaggagagg acctcagcca    11160

tgctcaccgt cagggccatg ccttccaagt tcatagaggg tctgaggaat gaagaggcca    11220

cagaagggga cacggccacg ctgtggtgtg agctgagcaa ggcggcaccg gtggagtgga    11280

ggaaggggca tgagaccctc agagatgggg acagacacag cctgaggcag gacgggtcca    11340

ggtgtgagct gcagatccgt ggcctggctg tggtggatgc cggggagtac tcgtgtgtgt    11400

gcgggcagga gaggacctca gccacactca ctgtcagggc cctgcctgcc agattcatag    11460

aagatgtgaa aaaccaggag gccagagaag gggccacggc cgtgctgcaa tgtgagctga    11520

gcaaggcggc ccccgtggag tggaggaagg ggtctgagac cctcagaggt ggggacagat    11580

acagcctgag gcaggatggg accagatgtg agctgcagat tcatggcctg tctgtggcag    11640

acactgggga gtactcgtgt gtgtgcgggc aggagaggac ctcggccaca ctcaccgtca    11700

gggccccaca gccagtgttc cgggagccgc tgcagagtct gcaggcggag gagggctcca    11760

cggccaccct gcagtgtgag ctgtctgagc ccactgctac agtggtctgg agcaagggtg    11820

gcctgcagct gcaggccaat gggcgccggg agccacggct tcagggctgc accgcggagc    11880

tggtgttaca ggacctacaa cgtgaagaca ctggcgaata cacttgcacc tgtggctccc    11940

aggccaccag tgccaccctc actgtcacag ctgcgcctgt gcggttcctc cgagagctgc    12000

agcaccagga ggtggatgag ggaggcaccg cacacttatg ctgcgagctg agccgggcgg    12060

gtgcgagcgt ggagtggcgc aagggctccc tacagctctt cccttgtgcc aagtaccaga    12120

tggtgcagga tggtgcagct gcagagctgc tggtacgcgg agtggagcag gaggatgcgg    12180

gtgactacac gtgtgacacg ggccacacgc agagcatggc cagcctctct gtccgtgtcc    12240

ccaggcccaa gttcaagacc cggcttcaga gtctggagca ggagacaggt gacatagccc    12300

ggctgtgctg tcagctgagt gatgcagagt cgggggccgt ggtgcaatgg ctcaaggagg    12360

gcgtggagct gcatgcgggc cccaagtacg agatgcggag ccagggggcc acgcgggagc    12420

tgctgatcca ccaactggag gccaaggaca cgggcgagta tgcctgtgtg acaggcggcc    12480

agaaaaccgc tgcctccctc agggtcacag agcctgaggt gaccattgta cgggggctgg    12540

ttgatgcgga ggtgacggcc gatgaggatg ttgagttcag ctgtgaggtg tccagggctg    12600

gagccacagg cgtgcagtgg tgcctacagg gcctgccact gcaaagcaat gaggtgacag    12660

aggtggctgt gcgggatggc cgcatccaca ccctgcggct gaagggcgtg acgcccgagg    12720

acgctggcac tgtctccttc catttgggaa accatgcttc ctctgcccag ctcaccgtca    12780

gagctcctga ggtgaccatc ctggagcccc tgcaggacgt gcagctcagt gagggccagg    12840

atgccagctt ccagtgccgg ctatccagag cttcaggcca ggaggcccgc tgggctttag    12900

gaggggtgcc cctgcaggcc aacgagatga atgacatcac tgtggagcag ggcacactcc    12960

acctgctcac cctgcacaag gtgacccttg aggatgctgg aactgtcagt ttccacgtgg    13020

gcacgtgtag ctctgaggcc cagctgaaag tcacagccaa gaacacggtg gtgcgggggc    13080

tggagaatgt ggaggcgctg gagggcggcg aggcgctgtt cgagtgccag ctgtcccagc    13140

ccgaggtggc cgcccacacc tggctgctgg acgacgaacc cgtgcacacc tcggagaacg    13200

ccgaggtggt cttcttcgag aacggcctgc gccacctgct gctgctcaaa aacttgcggc    13260

cacaagacag ctgccgggtg accttcctgg ctggggatat ggtgacgtcc gcattcctca    13320

cggtccgagg ctggcgcctg gagatcctgg agcctctgaa aaacgcggcg gtccgggccg    13380

gcgcacaggc atgcttcacc tgcacgctca gcgaggcggt gcccgtggga gaggcgtcct    13440

ggtacatcaa tggcgcggca gtgcagccgg atgacagcga ctggactgtc accgccgacg    13500

gcagtcacca cgccctactg ctgcgcagcg cccagcccca ccacgccggg gaggtcacct    13560

tcgcttgccg cgacgccgtg gcctctgcgc ggctcaccgt gctgggcctc cctgatcccc    13620

cagaggatgc tgaggtggtg gctcgcagca gccacactgt gacactgtct tgggcagctc    13680

ccatgagtga tggaggcggt ggtctctgtg gctaccgcgt ggaggtgaag gagggggcca    13740

caggccagtg gcggctgtgc cacgagctgg tgcctggacc cgagtgtgtg gtggatggcc    13800

tggcccccgg ggagacctac cgcttccgtg tggcagctgt gggccctgtg ggtgctgggg    13860

aaccggttca cctgccccag acagtgcggc ttgcagagcc accgaagcct gtgcctcccc    13920

agccctcagc ccctgagagc cggcaggtgg cagctggtga agatgtctct ctggagcttg    13980

aggtggtggc tgaggctggt gaggtcatct ggcacaaggg aatggagcgc atccagcccg    14040

gtgggcggtt cgaggtggtc tcccagggtc ggcaacagat gctggtgatc aagggcttca    14100

cggcagaaga ccagggcgag taccactgtg gcctggctca gggctccatc tgccctgcgg    14160

ctgccacctt ccaggtggca ctgagcccag cctctgtgga tgaggcccct cagcccagct    14220

tgccccccga ggcagcccag gagggtgacc tgcacctact gtgggaggcc ctggctcgga    14280

aacgtcgcat gagccgtgag cccacgctgg actccattag cgagctgcca gaggaggacg    14340

gccgctcgca gcgcctgcca caggaggcag aggaggtggc acctgatctc tctgaaggct    14400

actccacggc cgatgagctg gcccgcactg gagatgctga cctctcacac accagctctg    14460

atgatgagtc ccgggcaggc accccttccc tggtcaccta cctcaagaag gctgggaggc    14520

caggcacctc accactggcc agcaaggttg gggccccagc agccccctct gtgaagccac    14580

agcagcagca ggagccactg gctgctgtgc gcccaccact gggagacctg agcaccaaag    14640

acctgggtga tccctcaatg gacaaggcag ctgtgaagat ccaggctgcc tttaagggct    14700

acaaggtccg gaaggagatg aagcagcagg aagggcccat gttctcccac acatttgggg    14760

acaccgaggc acaggtgggg gatgccctgc ggctggagtg tgtcgtggcc agcaaggcag    14820

atgtgcgagc ccgctggctg aaggatggtg tggagctgac cgatgggcgg caccatcaca    14880

tcgaccagct tggggatggc acctgctctc tgctgatcac tggcctggac cgtgctgatg    14940

ctggctgcta cacctgtcag gtgagcaaca agtttggcca ggtgacccac agtgcctgtg    15000

tggtggtcag tgggtcagag agtgaagccg agagctcctc tgggggtgag ctggacgatg    15060

ccttccgccg ggctgcccgt cggctgcacc ggctcttccg caccaaaagt ccggctgaag    15120

tttcagatga ggagctcttc ctgagtgcag acgagggccc tgcagagcca gaggagcccg    15180

cggactggca gacataccgc gaagatgagc atttcatctg catccgtttt gaggcgctca    15240

ctgaggcccg ccaggcggta actcgcttcc aggagatgtt tgccacactg ggcattgggg    15300

tggagatcaa gctggtggaa caggggcctc ggagggtaga gatgtgcatc agcaaagaga    15360

ctcctgcccc tgtggtgcct ccagagccat tgcccagcct actgacttct gacgctgccc    15420

cagtgttcct gactgagttg cagaaccaag aagtgcagga tgggtatcct gtgagctttg    15480

actgcgtggt gacaggtcag cccatgccca gtgtgcgctg gttcaaggat gggaagttgt    15540

tggaggagga tgatcactac atgattaatg aagaccaaca gggtggccat cagctcatca    15600

tcacagccgt ggtgccagca gacatgggcg tctaccgctg cctggccgag aacagcatgg    15660

gtgtctcctc caccaaggct gagctccgtg tggacttgac aagcacagac tatgacactg    15720

cagcagatgc cacggagtcc tcatcctact tcagtgccca aggctacctg tccagccggg    15780

agcaggaggg aacagagtcc accactgatg agggccagct gccccaggtg gtggaggagc    15840

tgagagacct ccaggtggcc cctggcacac gcctggccaa gttccagctc aaggtgaaag    15900

gctaccctgc tcccagatta tactggttca aagatggcca gcccctgacc gcatctgccc    15960

acatccgcat gactgacaag aagatcctgc acaccctgga gatcatctcc gtcacccggg    16020

aggactctgg ccagtatgca gcctatatca gcaatgccat gggtgctgcc tactcgtctg    16080

cccggctgct ggttcgaggc cctgatgagc cagaagagaa gcctgcatca gatgtgcatg    16140

agcagctggt gccgccccga atgctggaga ggttcacccc caagaaagtg aagaaaggct    16200

ccagcatcac cttctctgtg aaggtagaag gacgcccggt gcccaccgtg cactggctca    16260

gggaggaggc tgagagaggc gtgctgtgga ttggccctga cacaccgggc tacaccgtgg    16320

ccagctctgc gcagcagcac agcctggtcc tgctggacgt gggccggcag caccagggca    16380

cctacacatg cattgccagc aacgctgccg gccaggccct ctgctccgcc agcctgcacg    16440

tctcgggcct gcctaaggtg gaggagcagg agaaagtgaa ggaagcgctg atttccactt    16500

tcctgcaggg gaccacacaa gccatctcag cacaggggtt ggaaactgcg agttttgctg    16560

accttggtgg gcagaggaaa gaagagcctc tggctgccaa ggaggccctc ggccacctgt    16620

ccctcgctga ggtgggcaca gaggagttcc tgcagaaact gacctcccag atcactgaga    16680

tggtatcggc caagatcacg caggccaagc tgcaggtgcc cggaggtgac agtgatgagg    16740

actccaagac accatctgca tccccccgcc atggccgatc acggccatcc tccagcatcc    16800

aggagtcttc ctcagagtca gaggacggcg atgcccgagg cgagatcttt gacatctacg    16860

tggtcaccgc tgactacctg cccctagggg ctgagcagga tgccatcacg ctgcgggaag    16920

gccagtatgt ggaggtcctg gatgcagccc acccactgcg ctggcttgtc cgcaccaagc    16980

ccaccaagtc cagcccctca cggcagggct gggtgtcacc agcctacctg gacaggaggc    17040

tcaagctgtc acctgagtgg ggggccgctg aggcccctga gttccctggg gaggctgtgt    17100

ctgaagacga atacaaggca aggctgagct ctgtgatcca ggagctgctg agttctgagc    17160

aggccttcgt ggaggagctg cagttcctgc agagccacca cctgcagcac ctggagcgct    17220

gcccccacgt gcccatagct gtggccggcc agaaggcagt catcttccgc aatgtgcggg    17280

acatcggccg cttccacagc agcttcctgc aggagttgca gcagtgcgac acggacgacg    17340

acgtggccat gtgcttcatc aagaaccagg cggcctttga gcagtacctg gagttcctgg    17400

tggggcgtgt gcaggctgag tcggtggtcg tcagcacggc catccaggag ttctacaaga    17460

aatacgcgga ggaggccctg ttggcagggg acccctctca gcccccgcca ccacctctgc    17520

agcactacct ggagcagcca gtggagcggg tgcagcgcta ccaggccttg ctgaaggagc    17580

tgatccgcaa caaggcgcgg aacagacaga actgcgcgct gctggagcag gcctatgccg    17640

tggtgtctgc cctgccacag cgcgctgaga acaagctgca cgtgtccctc atggagaact    17700

acccaggcac cctgcaggcc ctgggcgagc ccatccgcca gggccacttc atcgtgtggg    17760

agggtgcacc gggggcccgc atgccctgga agggccacaa ccgtcacgtg ttcctcttcc    17820

gcaaccacct ggtaatctgc aagccccggc gagactcccg caccgatacc gtcagctacg    17880

tgttccggaa catgatgaag ctgagcagca tcgacctgaa cgaccaggtg gagggggatg    17940

accgcgcctt cgaggtgtgg caggagcggg aggactcggt gcgcaagtac ctgctgcagg    18000

cacggacagc cattatcaag agctcgtggg tgaaggagat ctgtggcatc cagcagcgtc    18060

tggccctgcc tgtgtggcgg cccccggact ttgaagagga gctggccgac tgcacagccg    18120

agctgggtga gacagtcaag ctggcctgcc gcgtgacggg cacacccaag cctgtcatca    18180

gctggtacaa agatgggaaa gcagtgcagg tggaccccca ccacatcctc attgaagacc    18240

ctgatggctc gtgtgcactc atcctggaca gcctgaccgg tgtggactct ggccagtaca    18300

tgtgcttcgc ggccagcgcc gctggcaact gcagtaccct gggcaagatc ctggtgcaag    18360

tcccaccacg gttcgtgaac aaggtccggg cctcaccctt tgtggaggga gaggacgccc    18420

agttcacctg caccatcgaa ggcgccccgt acccgcagat caggtggtac aaggacgggg    18480

ccctgctgac cactggcaac aagttccaga cactgagtga gcctcgcagc ggcctgctag    18540

tgctggtgat ccgggcggcc agcaaggagg acctggggct ctacgagtgt gagctggtga    18600

accggctggg ctccgcgcgg gctagtgcgg agctgcgcat tcagagcccc atgctgcagg    18660

cccaggagca gtgtcacagg gagcagctcg tggctgcagt ggaagtcact gagcaagaga    18720

ctaaagtccc caagaaaacc gtcatcatag aagagaccat caccactgtg gtgaagagcc    18780

cacgtggcca acgacggtcc cccagcaagt ccccctcccg ctcaccttcc cgctgctctg    18840

ccagcccgct gaggccaggc ctactggccc ccgacctgct gtacctgcca ggtgctggcc    18900

agccccgcag gccggaggca gaaccaggcc agaagcccgt ggtgcccaca ctgtatgtga    18960

cggaggccga ggcccactct ccagctctgc ccggactctc ggggccccag cccaagtggg    19020

tggaggtgga ggagaccatt gaagtccggg tgaagaagat gggcccgcag ggtgtgtctc    19080

ccaccacaga ggtgcccagg agctcatcgg ggcatctctt cacactgccc ggtgcgaccc    19140

ccggagggga ccccaattcc aacaactcca acaacaagct gctggcccag gaggcctggg    19200

cccagggcac agccatggtc ggcgtcagag agccccttgt cttccgcgtg gatgccagag    19260

gcagtgtgga ctgggctgct tctggcatgg gcagcctgga ggaggagggc accatggagg    19320

aggcgggaga ggaagagggg gaagacggag acgcctttgt gacggaggag tcccaggaca    19380

cacacagcct tggggatcgt gaccccaaga tcctcacgca caacggccgc atgctgacac    19440

tggctgacct ggaagattac gtgcctgggg aaggggagac cttccactgt ggtggccctg    19500

ggcctggcgc ccctgatgac cctccctgcg aggtctcggt gatccagaga gagatcgggg    19560

agcccacggt ggggcagcct gtgctgctca gcgtggggca tgcactgggt ccccgaggcc    19620

ctctcggcct ctttaggcct gagccccgtg gggcgtcacc accgggaccc caggtccgta    19680

gccttgaggg cacctccttc ctcttgcggg aggccccggc tcggcctgtg ggcagtgctc    19740

cctggacgca gtctttctgc acccgcatcc ggcgttctgc ggacagtggc cagagcagct    19800

tcaccacaga gctttccacc cagaccgtca acttcgggac agtgggggag acggtcaccc    19860

ttcacatctg cccagacagg gatggggatg aggcggcaca gccctga                  19907


<210> 1561
<211> 7817
<212> DNA
<213> Homo sapiens

<400> 1561
agatggcgac cgcggcgctg cttcgaggcg ccactccggg gcgcggcggc ccggtctggc       60

gctggcggct gcgcgcggcc ccaaggtgcc gcctggccca cagctcctgc agtcctggtg      120

gcgacccaac ggccggagcg gcctgggcct gcttccggct ggacgggcgc accctgctgc      180

gcgtgcgtgg ccccgacgcg gcgcccttcc tgctagggct gctgaccaat gaactgccgc      240

ttccgagtcc tgcggccgcg ggggccccgc ctgctgcgcg cgcgggctac gcccacttcc      300

tgaacgtgca gggccggacg ctctatgacg tcatcttgta cgggctccag gaacactcgg      360

aggtgtctgg cttccttctg gagtgtgaca gctcggtgca gggcgcgctg cagaagcacc      420

tcgcgctata caggatccgg cggaaggtca cggtggagcc gcacccggag ctgcgagtgt      480

gggcggtgtt gcccagttcc cctgaggcct gcggggctgc atcgctgcag gagagggcag      540

gggctgccgc catcctcatc cgcgacccgc gaacagcacg catggggtgg cggctcctca      600

cccaggatga aggcccagcc ctggtgcccg ggggccggct cggggacttg tgggattatc      660

accagcaccg atacctgcaa ggcgttcctg agggggtccg agacttgcct cctggggtgg      720

ccctgcccct ggagtccaac ctggccttca tgaacggcgt gagcttcacc aaaggctgct      780

acattggcca ggagctgacg gcccgcaccc accacatggg cgtcatccgc aagcgcctct      840

tccctgtccg gttcttggac ccccttccca ccagtggcat cacccctggt gccacggtgc      900

tgactgcctc aggacagact gtgggcaagt tcagggctgg ccagggcaac gtggggctgg      960

ccctgctgtg gtcagagaag atcaagggtc ctctgcacat cagagcctct gagggtgccc     1020

aggtggcctt agccgcatct gtgccagact ggtggcctac agtctccaag tagtccgaag     1080

ccttggctgg cgcaggctga tggggaggct ggggcctggg gcctttggcc tctgtccagg     1140

gtcttcccgt cccatctgtc tgctgcgcct actgggtggg agccctggtt tccatctggg     1200

aaagtccccc ttgtaggtgc cctgcctggc cccacccatg ctcaggggcc ccaggcacgt     1260

gggttgtttt ctccctggac ttcctgtggc cccagaggag cccaccgtgt gagtgctggg     1320

ctccagatgg cgccgggtcc caatcgtggc tccacacagg gttgtctggg aggacgggac     1380

ggtgtctctg gccagcactg gcagcttccg ggccttgtac cccactctgc ctggcatgag     1440

cctcatgggg ggttggtccc tgtgcctgga agcggggtgg tgtccagggt ctgcaggctg     1500

gggctcgggc tttgggagtt gtttcactgt gcttgcttcc agcatgtctc agggtggggc     1560

tatgcgtggt ctagaggggt ctggggcatt ggatcaggtg gcatgtgggt gtctacacat     1620

cgagaagcac acagggatga gccactaggt atcccatgct ggaggcttgt ggaaggctgt     1680

gcccatctcc catgtttccc cacctctgtt cctcctcaga gccctccagg agcgtggggt     1740

gggggccagc gcagggctca ggagccagca gggcagagtt ctgcctgtgt gtgctgggtt     1800

ttggcatagc ctgtgtttgc agtgagagtg acttgctgtc agtcacgggg cacagcctcc     1860

tgttcaccca ctggcttccc ccttcccact gaagtgtgag ctctatgttt cagggcatct     1920

attaaagagt gagccacagg cagccccttg ggagctctgg tttcatttgg gggagaggga     1980

ggtgggggct tagtttttgt gatctggctg actggacccc gggaacagcg ctcctttgag     2040

aacgcccaga cctaccagat gaagcacttg gcatggctgc aggccagcag gggaggcctc     2100

agaggcccag gctgggcacg tgggtgccga gtctgcaaag gacagcccca tggctgtgag     2160

ctgtcggctg cagggcgcag ggcctggggg gcaggcgttt gggccaccaa gctggacgtt     2220

agggtggcca cagagggcca agcaggcagg gagcctgtgc cgccatcctg gggggccaca     2280

ggtgctctct agaaatctgc agccatggcg gttttggggt caggggtcta aaggcagctc     2340

tgagctgcag tgtagtttgt gatcacccag gaggagggtg tagagcggat ggacgggagg     2400

aagcggctgc agctggaggg aagagagggg ccgtccagcc tcacccgctg cagtcagctc     2460

tcctatgggc aaggaaacag ctaggtggcc ctgacccctg cggtcctgag agccggtggc     2520

cttcagcccc tcttggacag gtcatggtct ggaagcgccc agcgcaggat ggattccaga     2580

ccagcatccc tgcaaccttt tcagccccac tggctgctgc tttaaactgg catggagaca     2640

tttgatcagc ttcccagcca gttttctctc cagctcagcc aggagtgggt gcctgtggcc     2700

tgtgtcacca agagctggtg tctcctgcat gaggggcatg cacccctgga atgagggtct     2760

gtgcctcgag ctcaaagtgt cccggctctg tcatctgcct gaagttgcct ggcttttcca     2820

gtggggcctc cttgagtgct gcagcatctg ggagcatcct agcctgtccc gtgggtgtgg     2880

ctgggtgagg gctaggaggt gagccaggaa ggaagcactc cactccagag tgaggtgccg     2940

cctgagccat cctgtgcccc ctcagtgtct tcaggtctct gcaggtgtca ggatctcaaa     3000

atacttggtt cagatcaaac acatttcgtg ttcttctgtg tccttttttt tttttttttt     3060

tttttttgag atggagtctt gctctgttgg ccaggctgga gctcagtggc acaatctctg     3120

ctcactgcaa cctctgcctc ccaggttcca gtgattttcc tgcctcagcc tcctgggtag     3180

ctgggactac aggcacatgc cccatgcccg gctaattttt gtatttttag tagagatggg     3240

gttttaccat gttggccagg atggtctcaa ttacaggcat gagccactgt gcccagcctc     3300

ttctgtgtct ttaaaaagga aagtgtcagt caacaaaaga gcccctctgt catacaaacc     3360

aaatcagttt tcaccaaaat gtccttagtc ctctcagaaa ggcctggcct ttaggacctt     3420

ggaagcaggc cctaaagcgc atcggcaggg tcagagcttt gtgttcagga acactgggat     3480

ctgctgagag ctggtgtagc cgctccaaaa ctgcacactg cttttcctgt ctgctttagt     3540

ttgtgttgta aaaacatagg aagttcgtgt gtgtgtgtgt gtgtgtgaat tcaaggcata     3600

aggtgcagtt gtgttatgtg ggtatagtgc atggtggtgc agtctgggct tcttaccctc     3660

acacctcctg cctcccctcg ttagagtccc ccacatccgc cttccacttt ctgagcccac     3720

attgcctgtt gggcagctcc tggttatgag gcaggacgtg tggtgtttga ctgtctgttt     3780

ctgagctgtt ttacttaaca cagtgtatat ggtgcatctt taggaaagca tgcttgtatt     3840

ttcctttcaa agccagatat gggcgggtgt ggtggctcat gcctgtgatc ccagcacttt     3900

gggaggccga ggcaggagga ttgcttgagc ccaggagttt gagagcagcc tgggcaacat     3960

atcaagactc tgtctcttaa aaaaaaaaaa attagccagg catggtggtc cacacctgtg     4020

gtcccaccta ttcgggaggc tgaagtgcga ggatcacttg agcccaggag gttgaggctg     4080

cagtgagctg tgattgtgcc actgcactcc agcctgggca acagagcaag accctgtctt     4140

aaaacaaaga aagaataaaa aagaagagaa gttgcagttg gtagtatttc cagagcccgg     4200

cagacagtgt agaaactgtg agaaacccac ctccaaatca ggccttagat agaaaacatc     4260

ctaagaagta tacgttcatt gtaaaatcat tatcatcatc atcttctaat ccccaaggag     4320

acaagctccc tgttctgtgt tcttgtatga ggcggtcagt caagcgcagc ccgagaggag     4380

aggcaggagc ctgggagagc ctctgctaga cctttcctgg cacttcccca ggaaaggcaa     4440

ggcagggcag atgtgcggct ggccagctgg agtgatttcc atgggctcca agctgtagga     4500

gtggtccctg gctgccagag tgctctggcc agatagaggt gggctctgga ctggtgaggc     4560

tgcattgcgg aggcgcgcac acccagctgg gcccttatct gtaaggactg gctggcctgg     4620

gaggggcagt ctcccagcca gaaggtggaa tttttttttt tttttgagat accaaaacat     4680

cctaaggtac aggaaagaaa ttgtcaacac acacacacag taccataaac aaggcccagc     4740

agaaaggcag acagaagcac acacaccaat gttctgatct tagagtaagc agacacatca     4800

catggaatga ggatgtttaa tatatttaaa gaaaacaatt tatgcacagg aagcaagaga     4860

ctataaaaat gaccaagcag attttaaaaa gagaacttgt tgaaataaaa ataaaatact     4920

ctaaaaaata ttccatgatg tgtttcctga agaatcggga actgtttgaa gaaatgaccc     4980

aaagtgcagc acagaaagac agagctggaa aatatgagat gggatgagac aagaagatgg     5040

agagtttagt atgacatccg caatttacga gtaattccag aaggagggga aagagaatat     5100

ggggtggagg caagtattca gagaaatacg gctgagaact ttcccaaacc aacaggagcc     5160

cctgctcctt aggttcagga accagcagct cccaagcagc atagttaaaa agctctaccc     5220

aaacagtcac gtcttggtga aagtacagaa tctcatgaca aagagatctt aaggcagaaa     5280

agaaagagat tatctggaaa gaagaaaata agtagttgat taaaagcaac agtggaagcc     5340

agaaagatag taaataatat cttcaaagtc ctgggagaaa atagtgatag cctagaattg     5400

tgtacccaga aaatccgtct ttcaagaatg aggggccagg cgcagtggct cacgtctgta     5460

ttcccagcac tttgggaggc caaggcaggt ggatcacctg aggtcaggag ttcaagacca     5520

gcctgatcaa catggtgaaa ccctgtctct actaaaaata taaaaattag ctgggtgtgg     5580

tggcatattc ctgtaatccc agctactcgg gaggctgagg caggagaatc acttgaaccc     5640

aggaggcaga ggttgcagtg agccaagatt gtgccattgc actccagcct gggcaataga     5700

atgagactct gtctcaaaaa aaaaaaaaaa aaaaaaaaaa aaaagagggc taaacgcatt     5760

ttcataccac gaaactgccc tcactccgga gtttgctgcc agcagagcct agagcgtcta     5820

aggcatgtct gggcttctgg cgagggatcc tgtggggaag ctggagatgg aagaaggagt     5880

gaataggcag gaaggtggat ttgtgggcat gtctaaaaca ccacatctag aagcttctac     5940

ttagaatgcc tacttttgga gtttataaaa aagatgccac atgttgagtt gggagagagg     6000

tgcccaaacc tacagtgttc taaagtcccc ctactggtcg gaaggagggc acggacactg     6060

acttcagcat ctgttacaag gcttatcaga gttttcagat aatctctaaa agaatggaaa     6120

tatatcttcc aaactataga gggaagacca tggaatttaa aagccagtcc ttcaaggaga     6180

aatgaacaaa ctcaaaatcg tagttgggag tgtttttttt ttttttgaga cagagtctca     6240

ctcttgccca ggctggagtg gagtggcata aacacagctc actacagcct caaccttctg     6300

ggctcagatg attctcctgc ctcagcctcc tgagtagcag gaactacagg tgtgagtcat     6360

cacactcagc taattttttt tttttttttt tactttttgt agagatgggg ttctcactgc     6420

attgcccagg ctggtcttga atttctgggc tcaggtgatc ttcccacctc agcctcctga     6480

gtagctggga ccacaggtgc atgctaattt ttaaaatttt ttgtttttaa atgctggtct     6540

tcaactcttg tccccaagta gctgggattg gggcatgagg cactgtgcta acttcatgtt     6600

gaaattgaat tgccattcta acagtgttaa gagatggggc ctgtaagagg tgattaggct     6660

gtgagggctc cactctccaa gggcggagtt aatgttatga aagggtaagt ccagcccgct     6720

tgtgcctctc ttgccctcca gtgttcaaag caccatcttg gaggtggaat tcccaagtcg     6780

gccagttcct ggatcttgga ctgtccggtc tccagaaccg tgagccaata aacctctgtt     6840

ccttgtaaat gagtcagcct caggtattct cttgtagcag cacaaatgga ggcagacact     6900

tccttcacca atctcatggg aggcccactc ctgtgagctg cctctagttc cccaggccac     6960

agactccatc agggctcacc tggagccgtc cctgtctcac ctggaagctc tcccactcct     7020

ctggccagcc tgggcatctc cacccaatat gagtgatggc gactgattcc cttactttag     7080

caagctggga ataaggaatg tttgcctgtt cttattcagg ggtctctgca tctccacact     7140

tgcacaggtt gtgtgtacat acattttcct gtctttctgg taagcccctg gggtggagct     7200

ctgggccaca gggcaggaaa actcagtgtt gctaggaact gccagacatt ttcccggagt     7260

gagtgcagca tttacattcc caccagaagt gtgccaggtt cttgtcatac tgcgtcctcg     7320

ccagcgcttg gtgctgtcag tcttcttagt ttccatttag agattcagtg tttaaatttt     7380

gaacgtcttg ggtgaacacc ttggtttgag aaaagtaaga aaaagggtct gtctggctat     7440

gggccatgga gacccagggc agtgctccac gtgccaaccc tggggcaggg agcccaagct     7500

aggactgtga ctgtctgggc tgtgggcatc tgaccatctc cagtgtcccc gtctttgatt     7560

tccctggcga tggtgctagc ttagtttgtg cgcatcggca tttgtgggag aaatgaagga     7620

ttaatacatt ttgttttatg tcagactctc tcagtgagaa gttctcaggg acaataatag     7680

cagggggtcc tgctgaagaa aaactgggag atggctgagc tctggtccat ctttcattga     7740

ttcattcatt tcttcattca ttcaaccatg tattgaatgc ttatagccaa tgaaaataaa     7800

gtacacagta tatttta                                                    7817


<210> 1562
<211> 2362
<212> DNA
<213> Homo sapiens

<400> 1562
gcggccgccg ccccaccgta ggtccgtagc aggtggtcga agtcgggcct ccccgcgggc       60

gtcacccagc gccgccggct gccccagccc tgcgtgaagg cgctggaaaa cacgcagggc      120

aggttgggca gcaagaagcc ccgcacaaag tcggcgtagg agaaggcgcc cggctccgag      180

acgaaggcta cccggcccgg agcctggccg acgccgggga catcgacccc caggcctcgg      240

aagtggctgt cggcgagggc gcgcgtctcg cggtccatcc agctcagcac gggtcgaagg      300

accctcctcc tcacttccgc cggagcggaa acggtgagga ccagcctcgg aaccagaaga      360

cgcagggcgc cgcgtttctg ccccgccagc gcctggggct ccgggcctgc acgcatgcgc      420

gcggctcgcc gcggtcttca ctgcgcaggc gccgagcggc cgaggcgccg cggtcggctc      480

tgggactcgt ctggcgtccc tcagaggcag aagaggcctg gaccttggcg cacacagacc      540

caggaacaga tgagcaggga tgtctgcatc cacacctggc cgtgcaccta ctacctggag      600

cccaagaggc gatgggttac tggacagctg tccttaacat cgctgtcgct caggttcatg      660

actgacagca ctggagagat tctggtcagc ttccccctct ccagcatagt tgagatcaag      720

aaggaggctt cacattttat cttcagctcc atcaccatcc tggagaaggg ccatgccaag      780

cactggttca gctccctgcg gccaagtcga aatgtggtct tcagcatcat cgagcatttc      840

tggagggagc tgctgctgtc tcagcctgga gccgtggcag acgcatctgt cccaaggacc      900

cggggcgagg agctgacggg actcatggct ggatcccaga aacgcctgga ggacacggcg      960

agggtcctgc accaccaggg ccagcagctg gacagcgtca tgagaggcct ggacaagatg     1020

gagtcagacc tggaggtggc ggacagattg ctgacagaac tggaatctcc tgcttggtgg     1080

ccctttagct ccaagctttg gaagacacca ccggaaacaa agcccaggga agatgtctcc     1140

atgaccagtt gtgaaccctt tgggaaagaa gggatactga taaaaattcc tgctgttatt     1200

tcccacagaa cagagtctca cgttaaacca gggaggctca ccgtccttgt gtctgggttg     1260

gaaatacatg actccagttc tttgctcatg cacaggtttg aaagagaaga cgtggacgac     1320

atcaaggtcc actcacctta cgaaattagc atccgccagc ggtttattgg aaagccagac     1380

atggcctatc gtttgatatc tgccaagatg ccagaggtta tccccatttt agaagtgcag     1440

ttcagcaaga agatggagct gttagaagat gcattggtgc tcagaagcgc aagaacctct     1500

tcccccgcag agaagagctg ctcagtctgg catgcagcat ctgggctgat gggccgtacc     1560

ctgcaccgtg agccacccgc aggagaccag gagggcacag cactgcacct gcagacaagc     1620

ctgccagccc tttctgaggc agatacccag gaactaaccc agatcctgag gaggatgaag     1680

gggctggccc tggaggccga gagtgagctg gagagacaag acgaagccct ggatggcgtt     1740

gcagcagctg tggacagggc aaccttgacc atcgacaagc acaacaggcg gatgaagagg     1800

ctgacctagg ggcagaacgt ccctgcattc ctgtctcacc ctgcacatcc cgctgagatg     1860

gagggctggg cggcagtgcc agggctgcag aggcctgtgg ccctccggag tggtcttcct     1920

ctggatgggg ctgctactgt ggggctgctt ctgcaccagg ggcctcccca ggtgtgcacc     1980

atgcctgcct cccacttggc tgtccctgct gctgggcagg acccggccac atgttctgcg     2040

gatgctgcag aagtgtggac catggcggga ccccaaggac acttggcaca ggcctggaag     2100

aggccgccct cgtcttgtct cggctccctt tcatggacag actggccttc ttagctgtac     2160

tataaatttg tgagtgaagt tagagcccag ctcacttagc cagctcactt tgagggcatc     2220

ctataaacac ccaactgttc ttttatcgtc tcggttttag ccaaaagtga aattagcatg     2280

actgcatctt tcaaacaaaa atattgattt ctgcttttag ggccccgttt ccatccagaa     2340

ataaagggaa atgctggctt ca                                              2362


<210> 1563
<211> 1446
<212> DNA
<213> Homo sapiens

<400> 1563
atgagggcaa ggctccggtt cctgccctca cagggtccca gaagcaaggg cagtgaggac       60

ctggcccacg tccctggcac gggctgtctg attctccttc gctgtggcgg gaagatggcc      120

ggatttgaag attgctgaca gaactggaat ctcctgcttg gtggcccttt agctccaagc      180

tttggaagac accaccggaa acaaagccca gggaagatgt ctccatgacc agttgtgaac      240

cctttgggaa agaagggata ctgataaaaa ttcctgctgt tatttcccac agaacagagt      300

ctcacgttaa accagggagg ctcaccgtcc ttgtgtctgg gttggaaata catgactcca      360

gttctttgct catgcacagg tttgaaagag aagacgtgga cgacatcaag gtccactcac      420

cttacgaaat tagcatccgc cagcggttta ttggaaagcc agacatggcc tatcgtttga      480

tatctgccaa gatgccagag gttatcccca ttttagaagt gcagttcagc aagaagatgg      540

agctgttaga agatgcattg gtgctcagaa gcgcaagaac ctcttccccc gcagagaaga      600

gctgctcagt ctggcatgca gcatctgggc tgatgggccg taccctgcac cgtgagccac      660

ccgcaggaga ccaggagggc acagcactgc acctgcagac aagcctgcca gccctttctg      720

aggcagatac ccaggaacta acccagatcc tgaggaggat gaaggggctg gccctggagg      780

ccgagagtga gctggagaga caagacgaag ccctggatgg cgttgcagca gctgtggaca      840

gggcaacctt gaccatcgac aagcacaaca ggcggatgaa gaggctgacc taggggcaga      900

acgtccctgc attcctgtct caccctgcac atcccgctga gatggagggc tgggcggcag      960

tgccagggct gcagaggcct gtggccctcc ggagtggtct tcctctggat ggggctgcta     1020

ctgtggggct gcttctgcac caggggcctc cccaggtgtg caccatgcct gcctcccact     1080

tggctgtccc tgctgctggg caggacccgg ccacatgttc tgcggatgct gcagaagtgt     1140

ggaccatggc gggaccccaa ggacacttgg cacaggcctg gaagaggccg ccctcgtctt     1200

gtctcggctc cctttcatgg acagactggc cttcttagct gtactataaa tttgtgagtg     1260

aagttagagc ccagctcact tagccagctc actttgaggg catcctataa acacccaact     1320

gttcttttat cgtctcggtt ttagccaaaa gtgaaattag catgactgca tctttcaaac     1380

aaaaatattg atttctgctt ttagggcccc gtttccatcc agaaataaag ggaaatgctg     1440

gcttca                                                                1446


<210> 1564
<211> 540
<212> DNA
<213> Homo sapiens

<400> 1564
gccacgatgc cgcagtacca gacctgggag gagttcagcc gcgctgccga gaagctttac       60

ctcgctgacc ctatgaaggc acgtgtggtt ctcaaatata ggcattctga tgggaacttg      120

tgtgttaaag taacagatga tttagttcag tggcatttaa attactgtac tttaagacat      180

ggaattgctg gaggcttgga aacttgagtg caatttccct agtacgacct ccaaggagaa      240

tagagcaaaa cagtgtgttt ggtgtataaa acagaccaag ctcaagatgt aaagaagatt      300

gagaaattcc acagtcaact aatgcgactt atggtagcca aggaagcccg caatgttacc      360

atggaaactg agtgaatggt ttgaaatgaa gactttgtcg tgtacttagg aagtaaatat      420

cttttgaatt agagaaagtg ttgggacaga aagtacttta tgtaactaag tgggctgttc      480

agaagcttag aggtcatttt ttgtaatttt ctttttaatt actttagaga gctagggatg      540


<210> 1565
<211> 1596
<212> DNA
<213> Homo sapiens

<400> 1565
ggggctgctg ggactcgcgt cggttggcga ctcccggacg taggtagttt gttgggccgg       60

gttctgaggc cttgcttctc tttacttttc cactctaggc cacgatgccg cagtaccaga      120

cctgggagga gttcagccgc gctgccgaga agctttacct cgctgaccct atgaaggcac      180

gtgtggttct caaatatagg cattctgatg ggaacttgtg tgttaaagta acagatgatt      240

tagttagaca gtgtcttgct ctattgctca ggctgcagtg cagtggcatg atcatagctc      300

actgcatcct cgacctcctg ggctcaagcg gtcctcttgc ttcagcctcc tgaatagcag      360

agactacagt gtttggtgta taaaacagac caagctcaag atgtaaagaa gattgagaaa      420

ttccacagtc aactaatgcg acttatggta gccaaggaag cccgcaatgt taccatggaa      480

actgagtgaa tggtttgaaa tgaagacttt gtcgtgtact taggaagtaa atatcttttg      540

aattagagaa agtgttggga cagaaagtac tttatgtaac taagtgggct gttcagaagc      600

ttagaggtca ttttttgtaa ttttcttttt aattacttta gagagctagg gatgcaaatg      660

ttttcagtta gaaagccttt atttactttt ggaaattgaa caagaaatgc atctgtctta      720

gaaactggag attatttgat gttaggtaaa acatgtaatt gtttctctgg caaatttgta      780

tcagtaattt gaaaatgaga tattaggaaa aaccaattct tcttaaattt agttcatctt      840

tctttaaaag aacattaaat gtaaccattt tgtcagatcc atgtattttg gagcataaaa      900

tgtatgctgt tgtgaccaat aaatataaaa tatggtaatt ggaattaact ccacaccata      960

gtatgcattg ttatacatac tgtgtaccta attatgtata gcagtgtagt ctcaattata     1020

tctgaaagta attgtgacta acaagtatgc tttgccttat ttccacattt aaactacctg     1080

ttaatataag ggatttgtag tatcagcttg ttgagcaatg actttgaatc tagttttcag     1140

tgatcagaag cagcagttat ttgagtgtat gaatggaatg atgatcactg tgctataatg     1200

tactgaaacc accatattac agaaatattt actacatatt ttccatctgt agtttctcag     1260

aagggctatg gattagtttg aactgtcaaa tccttgcata cttctgtgac acccctgccc     1320

attttctgtc tttaattaac caaggtgtta ggtgtgactg tcacaactgt tatgttttcc     1380

agtaaactag aagtacgata tttgataatt atatttgtat ttcaccacct aaatgtaatg     1440

ttgattcctc aagaatgaaa tgaaggcact acattgaaat atgttttgta taaatttgtc     1500

atgttgaaca gcattttagc atggtaagtt cccttagcta tatgaatttt ggcatgtttc     1560

agagagatca gtaaataaaa tattagataa aatata                               1596


<210> 1566
<211> 2890
<212> DNA
<213> Homo sapiens

<400> 1566
atgcaggcca atggggcagg aggaggagga ggaggtggcg gcggcggcgg tggaggagga       60

gggggcggcg ggggccaggg acagaccccg gaactcgcct gcttgtcggc ccagaacggg      120

gagtcgtccc cctcgtcgtc gtcgtccgcg ggggacctgg cccacgccaa tgggctcctg      180

ccttccgccc cctccgccgc cagcaacaat agcaacagcc tgaatgtcaa taacggggtt      240

cccggcgggg cggccgccgc atcctcagcc accgtcgcag ctgcctccgc caccaccgcc      300

gcctcctctt ccttggccac cccagaactg ggcagcagcc tcaagaagaa gaagcggctc      360

tcccagtcag atgaggatgt cattaggcta ataggacagc acttgaatgg cttagggctc      420

aaccagactg ttgatctcct catgcaagag tcaggatgtc gtttagaaca tccttctgct      480

accaaattcc gaaatcatgt catggaagga gactgggata aggcagaaaa tgacctgaat      540

gaactaaagc ctttagtgca ttctcctcat gctattgtgg cacaaacatt ttctgaaact      600

tccatcaact tttttcccct gactgctgct ttctgtcatg tcagaggatg aagtttttgc      660

tgctgcagca gaagtaccta gaatacctgg aggatggcaa ggtcctggag gcacttcaag      720

ttctacgctg tgaattgacg ccgctgaaat acaatacaga gcgcattcat gttcttagtg      780

ggtatctgat gtgtagccat gcagaagacc tacgtgcaaa agcagaatgg gaaggcaaag      840

ggacagcttc ccgatctaaa ctattggata aacttcagac ctatttacca ccatcagtga      900

tgcttccccc acggcgttta cagactctcc tgcggcaggc ggtggaacta caaagggatc      960

ggtgcctata tcacaatacc aaacttgata ataatctaga ttctgtgtct ctgcttatag     1020

accatgtttg tagtagactg gtgaattgac aaaatgtaat tctaaattat tgattgggaa     1080

aagaagcaag gaagaccgtg tttcaagata cacttaaagg aggcagttcc catgttatac     1140

gcagcagata cttacggagc attgtaatga agtgtggttc tgtaaattct ctaatgatgg     1200

cactaaacta gcaacaggat caaaagatac aacagttatc atatggcaag ttgatccgga     1260

tacacacctg ctaaaactgc ttaaaacatt agaaggacat gcttatggcg tttcttatat     1320

tgcatggagt ccagatgaca actatcttgt tgcttgtggc ccagatgact gctctgagct     1380

ttggctttgg aatgtacaag aaaactatcc ccatgtacct tttattatta caccaagggc     1440

agctattatc tctcagatcc tgtttctaat ccatgaacaa aatggaatca agactagatt     1500

aaatgacagg agaactaagg acaaaaatga gccagtctca tgaagacagt ttgacaagtg     1560

tggcttggaa tccagatggg aagcgctttg tgactggagg tcagcgtggg cagttctatc     1620

agtgtgactt agatggtaat ctccttgact cctgggaagg ggtaagagtg caatgccttt     1680

ggtgcttgag tgatggaaag actgttctgg catcagatac acaccagcga attcggggct     1740

ataacttcga ggaccttaca gataggaaca tagtacaaga agatcatcct attatgtctt     1800

ttactatttc aaaaaatggc cgattagctt tgttaaatgt agcaactcag ggagttcatt     1860

tatgggactt gcaagacaga gttttagtaa gaaagtatca aggtgttaca caagggtttt     1920

atacaattca ttcatgtttt ggaggccata atgaagactt catcgctagt ggcagtgaag     1980

atcacaaggt ttacatctgg cacaaacgta gtgaactgcc aattgcggag ctgacagggc     2040

acacacgtac agtaaactgt gtgagctgga acccacagat tccatccatg atggccagcg     2100

cctcagatga tggcactgtt agaatatggg gaccagcacc ttttatagac caccagaata     2160

ttgaagagga atgcagtagc atggatagtt gatggtgaat ttggagcaga cgacttctgt     2220

ttaacttaaa attagtcgta ttttaatggc ttgggatttg gtgcaaacaa acatgattga     2280

tagctggaca gacatgctcg tcatgaaaaa agaaccattt ctgaagcccg attggggcca     2340

aacatttaca ccttgcttca tagtaaccag ttgagatgaa gcacgtcgtt agaacgttgt     2400

tggacaccat gttgaattat tcccccatcg gttgtgaaga actgtgctac attcaggctt     2460

acccattgaa ctcagtatat atattttttt ccttcctgtc ttttgtctgg caggatacca     2520

ttcttgttgc tcttctgtgt aatgaagttt aaatgcttgt ttggaaaact ttatttaaca     2580

gtttagaagg cttgatagaa agagtgcatt agtctgaaga gtatacattg gataggaaag     2640

aatttccttc ttttgtttct ccaaatcttt ccgccttatt tagcttgaga tctttgcagc     2700

ttggttcatg gattctagcc ttgcccgttg cgcagtatat actgatccag atgataaacc     2760

agtgaactat gtcaaaagca ctctcaatat tacatttgac aaaaagtttt gtacttttca     2820

catagcttgt tgccccgtaa aagggttaac agcacaattt tttaaaaata aattaagaag     2880

tatttatagg                                                            2890


<210> 1567
<211> 8233
<212> DNA
<213> Homo sapiens

<400> 1567
ccaggcggcg gcggccaaac tccgcggcgt ccccagggcg ccagcttcgc cctcgccgcc       60

gcggccgcgc tgctcttcgg ctccgacatg gaagatggac cttctaataa tgcgagctgc      120

ttccgaaggc tgaccgagtg cttcctgagc cccaaatgag gatagaagag aggaaatccc      180

aacatttaac aggtttgaca gatgaaaaag tgaaggcata tctttctctt cacccccagg      240

tattagatga atttgtatct gaaagtgtta gtgcagagac agtagagaaa tggctgaaga      300

ggaagaacaa caaatcagaa gatgaatcag ctcctaagga agtcagcagg taccaagata      360

cgaatatgca gggagttgta tatgaactaa acagctatat agaacaacgg ttggacacag      420

gaggagacaa ccagctactc ctctatgaac tgagcagcat cattaaaata gccacaaaag      480

ccgatggatt tgcactgtat ttccttggag agtgcaataa tagcctgtgt atattcacgc      540

cacctgggat aaaggaagga aaaccccgcc tcatccctgc tgggcccatc actcagggca      600

ccaccgtctc tgcttatgtg gccaagtcca ggaaaacact gctagtagaa gacatccttg      660

gagatgaacg atttccaaga ggtactggac tggaatcagg gactcgtatc cagtctgttc      720

tttgcttacc aattgtcact gcaattggtg acttgattgg tattctcgag ctgtatcggc      780

actggggcaa agaagccttc tgtcttagtc accaggaggt tgcaacagca aatcttgcct      840

gggcttcagt agcaatacat caggtgcagg tatgcagagg ccttgccaaa cagacagaat      900

tgaatgactt cctactcgac gtatcaaaaa catattttga taacatagtt gcaatagatt      960

ctctacttga acacataatg atatatgcaa aaaacctggt gaatgccgat cgttgtgcgc     1020

ttttccaggt ggaccataag aacaaggagt tatattcaga cctttttgat attggagagg     1080

aaaaggaagg aaaacctgtc ttcaagaaga ccaaagagat aagattttca attgagaaag     1140

gaattgctgg ccaagtagca agaacagggg aagtcctgaa cattccagat gcctatgcag     1200

acccacgctt taacagagaa gtagacttgt acacaggcta caccacgcgg aacatcctgt     1260

gcatgcccat cgtcagccga ggcagcgtga taggtgtggt gcagatggtc aacaaaatca     1320

gtggcagtgc cttctctaaa acagatgaaa acaacttcaa aatgtttgcc gtcttttgtg     1380

ctttagcctt acactgtgct aatatgtatc atagaattcg ccactcagag tgcatttacc     1440

gggtaacgat ggaaaagctg tcctaccata gcatttgtac ttcagaagag tggcaaggtc     1500

tcatgcaatt cacccttccc gtgcgtctct gcaaagaaat tgaattattc cactttgaca     1560

ttggtccttt tgaaaacatg tggcctggaa tttttgtcta catggttcat cggtcctgtg     1620

ggacatcctg ctttgagctt gaaaagttgt gtcgttttat tatgtctgtg aagaagaact     1680

atcggcgggt tccttatcac aactggaagc atgcggtcac tgtagcacac tgcatgtatg     1740

ccatacttca gaacaatcac acgcttttca cagaccttga gcgcaaagga ctgctgattg     1800

cgtgtctgtg tcatgacctg gaccacaggg gcttcagtaa cagctacctg cagaagttcg     1860

accaccctct ggccgctctc tactccactt ccaccatgga gcagcaccac ttctcccaga     1920

ctgtgtccat cctccagttg gaagggcaca atatcttctc cactctgagc tccagtgaat     1980

atgagcaggt gcttgagatc atccgcaaag ccatcattgc cacagacctt gctttatact     2040

ttggaaacag gaagcagttg gaagagatgt accagaccgg atcactaaac cttaataatc     2100

aatcacatag agaccgtgta attggtttga tgatgactgc ctgtgacctt tgttctgtga     2160

caaaactgtg gcccgttaca aaattgacgg caaatgatat atatgcagaa ttctgggctg     2220

agggtgatga aatgaagaaa ttgggaatac agcctattcc tatgatggac agagacaaga     2280

aggatgaagt cccccaaggc cagcttgggt tctacaatgc cgtggccatt ccctgctata     2340

caacccttac ccagatcctc cctcccacgg agcctcttct gaaagcatgc agggataatc     2400

tcagtcagtg ggagaaggtg attcgagggg aggagactgc aacctggatt tcatccccat     2460

ccgtggctca gaaggcagct gcatctgaag attgagcact ggtcaccctg acacgctgtc     2520

ccacctacag atcctcatct tgcttctttg acattctttt cctttttttg gggggggtgg     2580

ggggaacctg cacctggtaa ctggggtgca aacctcttca agaaggtaac atcaaataaa     2640

taagtcaagc agaggacttc ctgccaatct cttctgtgag gcatcataga cactgagcaa     2700

ccaggaccac ccccacgttc agaaatcagc tggccaagtg actccatttg acttgcaaac     2760

cagccttttc taataggcta atattgctga ggccttaaag gaaatggaca aaaattatcc     2820

agaaggggta cttttccatt gtatctttct aataagggtt taaaatggta ctattatggt     2880

attgtacttg ggctttaaca tcaatgttgc tttgatgttg ttggatataa ataggaattt     2940

ttacacatta ctattgtgaa tggtgaatgt tcatgtatga cctacttgta attaacttga     3000

gttgtagtcc acagcctcag gacaaatgtc gttgaggtta cagagtaaga aatgatggca     3060

aaacgtcaaa ctcttatttc agagcttcat gaatttagtt agactaaaca taattcttta     3120

agttcaacct aaagggctga gatcaataaa tttaacacta gacgaagtag acttcctgtc     3180

tttttgagaa gagatgaggt atatgttaca ataaatctca gaacttcaag tagcagttca     3240

aaagatgtca gtttttaaaa ttgtttttgt tgttgtcttg gcagttttac tgaacccttt     3300

gcataaagaa caaaataaaa gctcggcatt gtaatttttt taatggacaa gtcttatgga     3360

tacgaagggt acatttttca taatgattcc tttatatttt cactttgtgt cattgcagaa     3420

ttttagactc tcattcacaa tgaaaagttt attttaaaca ttgtttaatt aaaataccat     3480

acagttctct tttaaacatc aaaccataaa aagtgtattt tgtaatttta ctctgacctg     3540

ccgcagtcac ctctcactta tctcttccac gtactgcacg gtcgtatttc atgagctttc     3600

tgtccatagc acagaaacag agcagaaagt agtacaatca tgttggacct tctttctgtt     3660

ctctttactc ttctcacaga tcagatcact ccatagaagc ctgtgggttt cgatggtttc     3720

ttctatacac ctttttggtt gaccagtatt actatacaat gtaagtgttt taaaaaatac     3780

gaaagtaata ctctgcaccc cttcctacaa agatgataaa gcagtcactt ctggcgcatt     3840

ttaataattt aaagattttt agtgcaatgg cacggtaacc tccaaacctg aattagacag     3900

agactcactc aggaagtgac aggcccatca tatcaaataa cttattcact tttcatgtgg     3960

caggaaactg gaatatcgct tttaataaaa tggaaaaata tgcttctaca tatttaccac     4020

cataggcgtt ttgttcatat gagcctggtt tgtgcaaaat taaatcagag gcttctacaa     4080

catggtttat ttatgttgta gcaaagttgg ctctacataa acattgttct tattttaaaa     4140

ttaacactat gtgttcagtt ttcttgtggg cttctgaaag ttgccatctt ccctccgtgg     4200

agctccattt gctattttca ttatacacta tgaggtaaaa tgtaataaca aaagagagag     4260

aagtaccact gtggctagat atatacacac acatatatat atggatggat gtaatatatg     4320

tagaacacac acatagatgt atataggata cacactcatg tatgtaaacg tatacatatg     4380

tgtatatatg atacatacac atacacacac acgagagaca gaaggaaaga gaggaagaga     4440

gaagcaaaca tgtaggaaaa aatataaatc agccccattc tcccattctt taagaacaat     4500

gatttttctt gatggaaaat gcatatcact tgacagttga caagaaagtg tcatttttgt     4560

gttagtgtat catataattg aatttgaaca agatacatat ttttctgcat acaaatttat     4620

gaagctggag tctaccaaac acagctttag tcacaaaagt tagtttagtt atctcatttc     4680

gcttggagat ggaatttcag gaagggatat attatttaag attattgttt aattacaaga     4740

attttaaaag aatgtatgaa ttctgttttt taatatagaa aataattatg gagttaggaa     4800

tctcatggct acatttacat ttttaggtta ttacagaaaa ttctcttaat ttattatagt     4860

caagtgtatt atgtaatctc tatttagaac agtttcccaa aggaatgtga ttggatttac     4920

tggttggtta atttcttgtg aaatattgtc ataatagaag cacagcttga acaaaagact     4980

gaattctgat ataaactgtc aatattgctt ttaccatgtg taagatttac ttagtaatca     5040

cagatttacc taaaataaaa ggacccgggt tgcagtgata tttagttaat gatttgtttt     5100

ggaaaacatg cagttaggag tatttttgta ttttgtcaga tgtttaggag acagactttc     5160

gggtcatgtt tcttgtcttg ttcccagatc ttttcttaaa agaacagtgt gacaccagaa     5220

gccaagagat ggtttttact aacaacagct ttgatgagtt cctattaagg tcgtattgtg     5280

tattgtgcca aattttccac ccagtataaa tttagtaacc cgctatgagc atatgtagga     5340

tattcaattt gcagatactt ttgttggtta tgttggttta taatagacaa gttttatggt     5400

catatgcaat tattccatta tctttttgga cacagtgaat atgtttttta gctaaaaatg     5460

tccttggaaa cataaatgcc tgccaataac atggaatatt gaattcgggc aatgtgaatt     5520

gattaattag aaaagggtca aaagaaatac aatggatgtg gaaactaatt ctaaaaaata     5580

gccctattaa tagggcagag actctggtcc atttcccagc tgtacttctc tctaagaggt     5640

gtatgaaaaa cccatcttgc aaaagagacc aaaatattag acacaatcgt tcccattcct     5700

gactcttcaa tggaaaagga aggtacagat gtttacagtg gtgccccagg tgactcgttc     5760

tcaccacaac aaaagcaact aattggaaac tagatgtgtt caataataga tttcctcttt     5820

tttggcatgc tttttagatt ttttttcatt ttgtaaaatc tcagttaatt tttctttatt     5880

ggtatatttg tgtatgcgag acaaatcctg tattgtacag gatataaata gatgcataaa     5940

tccttagata cctgggtttt ttaataggtt taggtttggg tattgtgttt ctggtctttt     6000

aactcaaaat taaggtttga gctttaatag gactaaatta ttcacctgcc ttggcctgtg     6060

cctttatttt aaatactgca attttacttc ttcattcatg tatttattat tttgcttttc     6120

ttgcttaagt ataattgaaa atatttgcag gaacgcacaa ttcattttat caagttgaat     6180

gaataggacc attctctcct catcagattt ctgttcttta tttgacttca ttgacatata     6240

ccctggtgac tataaccagt gaactgttca gagtcagtct tttcggcaag aacttcagag     6300

aactgtgaca ctggttatga tgtgattttg gggggtttca ggtacctaag catgattttt     6360

aaaatcactt ctctctttac atatttcgaa catatgtttg ctttctacac tttgcagatt     6420

ttatttagga tttaattctt taaagactat attcatttag tcactatagt ggatctcttc     6480

tactgcaagt attcatctga tttttaaatt atgtaaaatg taaatcagcc aagtatgtca     6540

tccgttatag tttccccatg ctttcagcgc atggccatga gatttttaca tgtgcataag     6600

tatttagcca atacacattt tgctgacttc tttaaccatt tatattgttt aaattagtaa     6660

tatccaatgc agtgcacact tttttgtctt ttttccaacg gaatattttg gttgtctgta     6720

gcgttggaag cattttatat gataaaaata gcaagaaaaa attaaaaagt gtcaacggtg     6780

tgctggttct aaattaagaa gatagaacaa agagaaagac attaatgtta cctaagaaac     6840

acatttaaca tccgaagaag caatgctgtc ctcacttgat gtttctcttc tcaacccagc     6900

aatggagagc agggcttgca aagccgtaca gagcctacgt gctctttcct gcaagtggga     6960

gaaaactaat caatggcaca cagggccagg tgtggccctg tgaggcaaag gataatgtca     7020

cctcaggacc aaggtggaaa cttacagctg aatccagggc ttactaagta gggaagtcag     7080

tttacatatt tcagttttcc tctgatgttt ttgaggtact gtgtatttgc agaagtttaa     7140

gcagaagggt tttgtttcta ttgtaagtta ggttctaaaa gtgtataatc tgatactcta     7200

gcccaactga aatattatat cttgggcgtt acagcctttg tctttttctt tagtcacctt     7260

aatacccagt cctatgctgt atctctgata gcctatataa atgacatata ggaatattat     7320

tttccatatg atctgttgta tggtgtatat gctatgtgtt catttcgtgt gcaagttcag     7380

agtgtaatag atttacccag agaaggtgtt tctatacaat gcccctacct atttgaaatt     7440

acatgcttgc ccaacacact gtgaaatagt taccaaaatt tgtacaaatg cagcatcttc     7500

attctttctg agaagacaag atggttttct ttacatgaac aaatgaacaa aagagatcct     7560

agatccataa cgtagctaag gcatctaaga gtttgctgtt gataatcttg ctgaccaaaa     7620

actactggag agtaacacag gttatatgcc atcacaaata caatgctcat gaagaactga     7680

tttgtagagt caatgaacct gtgtccagaa ttttaatagg ctctctattg gaaggagaaa     7740

gaatttcaag ttaacagtat ctaactttat catagttgat gttagtaaat tttaaaaaat     7800

gattttatat gtatgacaaa aatctttgta aaatgcgcaa gtgcaataat ttaaagaggt     7860

cttaactttg catttataaa ttataaatat tgtacatgtg tgtaattttt tcatgtattc     7920

atttgcagtc tttgtattta aaaaacattt actgttatgt ttgtataata gaacagtaat     7980

catttattat aatctaggca agttgtaaat aaattcataa ttcaaacagc cagtatatat     8040

gcatatatga gtgttatatt gcaaaatctt tgttttactt acatggttaa agcagcaaga     8100

attcttttgt tgatatgtaa ttatacacat aaaatatata tatgtatgat acatgaaata     8160

tatttagaaa tgttcataat tttaatggat atcctttggt gtgaataatt gaatacagag     8220

tttttaaaat atc                                                        8233


<210> 1568
<211> 1819
<212> DNA
<213> Homo sapiens

<400> 1568
ggcagtggca tcagcgatgg cggctgcgtc ggggtcggtt ctgcagcgct gtatcgtgtc       60

gccggcaggg aggcatagcg cctctctgat cttcctgcat ggctcaggtg attctggaca      120

aggattaaga atgtggatca agcaggtttt aaatcaagat ttaacattcc aacacataaa      180

aattatttat ccaacagctc ctcccagatt taaaataacc aatgactgcc cagaacacct      240

tgaatcaatt gatgtcatgt gtcaagtgct tactgatttg attgatgaag aagtaaaaag      300

tggcatcaag aagaacagga tattaatagg aggattctct atgggaggat gcatggcaat      360

acatttagca tatagaaatc atcaagatgt ggcaggagta tttgctcttt ctagttttct      420

gaataaagca tctgctgttt accaggctct tcagaagagt aatggtgtac ttcctgaatt      480

atttcagtgt catggtactg cagatgagtt agttcttcat tcttgggcag aagagacaaa      540

ctcaatgtta aaatctctag gagtgaccac gaagtttcat agttttccaa atgtttacca      600

tgagctaagc aaaactgagt tagacatatt gaagttatgg attcttacaa agctgccagg      660

agaaatggaa aaacaaaaat gaatgaatca agagtgattt gttaatgtaa gtgtaatgtc      720

tttgtgaaaa gtgattttta ctgccaaatt ataatgataa ttaaaatatt aagaaataac      780

actttcctga cttttttatt attaaaatgc ttatcactgt agacagtagc taatcttatt      840

aatgaaaaac aatagacaaa catctgtgca taatttttca gacacaattc tgtaaatatt      900

tggaaacctt ttaagtattt aaacttttaa atttttgaaa taaagtattc taaactaata      960

taaataagga caatgaaaaa acatgaaagg acttagcata atgttatttt atcttttcta     1020

caactttgtt taaattacct ttccaaagat atttgtgttt atgtaatttt ccacggaata     1080

acattaatac tctaggttta taaaccggtt tcacattatt tcatttgatc atcacaagag     1140

ctttgtgaag taagccgaga agttgttact ggtatttaat aatagcaata gaggagttaa     1200

agactttccc acagcttgca ggtcaagaca agaaattcag gtctcctaat tctcagtgga     1260

gctctatttc tgttaaccca aattgctgct ctgttttagg tctcaatttc atctgtaaaa     1320

tgatactaat agtacttatc ccattggatt tttgttgaga tttaaataaa tagccaaaag     1380

ccaatacata ataaacactc aataaagatt aaccataagg agagtcatga tctggttcca     1440

ggaatacatt gttagatgac tgaaaaattg tattacttca atgaaaatac tataaataat     1500

aacattttca tatattagtt ggttctcatg catacataat ctaattttat ttgatcctca     1560

caactgttta agttttatta aatatacatt atccctattt gtataaatag aatcatacaa     1620

tacctgcctg ctttcattca acaaaattat catgagattt ttccatgttg tgtacatcaa     1680

tagttcatct attttattgc tcagtaatat tccattgtgt ggatgtatca ctatttgttt     1740

acacattcac cactgatata taagttgctt ccagtgtgag gctgttttaa ataaagctgc     1800

tatgaatatt catgtaaga                                                  1819


<210> 1569
<211> 1898
<212> DNA
<213> Homo sapiens

<400> 1569
cgcggcaacg caggggcgga accgcatgac tggcagtggc atcagcgatg gcggctgcgt       60

cggggtcggt tctgcagcgc tgtatcgtgt cgccggcagg gaggcatagc gcctctctga      120

tcttcctgca tggctcaggt gattctggac aaggattaag aatgtggatc aagcaggttt      180

taaatcaaga tttaacattc caacacataa aaattattta tccaacagct cctcccagat      240

catatactcc tatgaaagga ggaatctcca atgtatggtt tgacagattt aaaataacca      300

atgactgccc agaacacctt gaatcaattg atgtcatgtg tcaagtgctt actgatttga      360

ttgatgaaga agtaaaaagt ggcatcaaga agaacaggat attaatagga ggattctcta      420

tgggaggatg catggcaata catttagcat atagaaatca tcaagatgtg gcaggagtat      480

ttgctctttc tagttttctg aataaagcat ctgctgttta ccaggctctt cagaagagta      540

atggtgtact tcctgaatta tttcagtgtc atggtactgc agatgagtta gttcttcatt      600

cttgggcaga agagacaaac tcaatgttaa aatctctagg agtgaccacg aagtttcata      660

gttttccaaa tgtttaccat gagctaagca aaactgagtt agacatattg aagttatgga      720

ttcttacaaa gctgccagga gaaatggaaa aacaaaaatg aatgaatcaa gagtgatttg      780

ttaatgtaag tgtaatgtct ttgtgaaaag tgatttttac tgccaaatta taatgataat      840

taaaatatta agaaataaca ctttcctgac ttttttatta ttaaaatgct tatcactgta      900

gacagtagct aatcttatta atgaaaaaca atagacaaac atctgtgcat aatttttcag      960

acacaattct gtaaatattt ggaaaccttt taagtattta aacttttaaa tttttgaaat     1020

aaagtattct aaactaatat aaataaggac aatgaaaaaa catgaaagga cttagcataa     1080

tgttatttta tcttttctac aactttgttt aaattacctt tccaaagata tttgtgttta     1140

tgtaattttc cacggaataa cattaatact ctaggtttat aaaccggttt cacattattt     1200

catttgatca tcacaagagc tttgtgaagt aagccgagaa gttgttactg gtatttaata     1260

atagcaatag aggagttaaa gactttccca cagcttgcag gtcaagacaa gaaattcagg     1320

tctcctaatt ctcagtggag ctctatttct gttaacccaa attgctgctc tgttttaggt     1380

ctcaatttca tctgtaaaat gatactaata gtacttatcc cattggattt ttgttgagat     1440

ttaaataaat agccaaaagc caatacataa taaacactca ataaagatta accataagga     1500

gagtcatgat ctggttccag gaatacattg ttagatgact gaaaaattgt attacttcaa     1560

tgaaaatact ataaataata acattttcat atattagttg gttctcatgc atacataatc     1620

taattttatt tgatcctcac aactgtttaa gttttattaa atatacatta tccctatttg     1680

tataaataga atcatacaat acctgcctgc tttcattcaa caaaattatc atgagatttt     1740

tccatgttgt gtacatcaat agttcatcta ttttattgct cagtaatatt ccattgtgtg     1800

gatgtatcac tatttgttta cacattcacc actgatatat aagttgcttc cagtgtgagg     1860

ctgttttaaa taaagctgct atgaatattc atgtaaga                             1898


<210> 1570
<211> 1101
<212> DNA
<213> Homo sapiens

<400> 1570
ggaacatcgg cggctgcccg ggtgacttgg ttatatgtca cagaataaca ttcgagaatg       60

ggacatggaa tgaggcgacg gccccagcaa gccccagcag ccccagcccc agccccaggc      120

ccagcagcag cagcagcagc ccctgctctc ccgccgcccg gagaggctct gcagccatga      180

agccaaccgt cccgaggcac cgccggtaag cagggagcct ccgcggagct cccgccgccg      240

ctcccccttg gcgccaaagg cacccggtcc cggagcagcc acgcgcggcc cgtgagcctc      300

gccaccagcg ggggctcaga ggaggaggac aaagacggcg gggtgctgtt ccacgtcaac      360

aagagcggct tccccatcga cagccacacc tgggagcgca tgtggatgca cgtggccaag      420

gtgcacccta aggggggaga aatggtgggc gccatcagga acgccgcctt cttggcaaag      480

ccttcaatac cccaggtccc aaactacagg ctgtcgatga cgatcccaga ctggctccag      540

gcgatccaga attacatgaa gaccctacaa tataatcaca cagggaccca gttctttgaa      600

attaggaaaa tgagaccgct gagtgggtta atggaaacag caaaagaaat gacccgagag      660

tccttgccta tcaaatgcct tgaagctgtc atcctgggca tctacttaac caatgggcag      720

ccttccattg agcggttccc catcagcttt aaaacctact tctcaggaaa ctactttcac      780

cacgttgtgc tggggattta ctgcaatggc cgctatggct cattgggcat gagccgcagg      840

gctgagctga tggacaagcc attgactttt cggactctga gtgacctcat ctttgacttt      900

gaggactctt acaagaaata cctgcacaca gtcaagaagg tcaagattgg gctgtacgtc      960

ccccatgagc ctcatagctt ccagcccatt gagtggaagc agctggtcct caacgtctca     1020

aagatgctga gggctgacat aaggaaggag ctggagaaat atgccaggga catgagaatg     1080

aagggcttgt gcagtcacta a                                               1101


<210> 1571
<211> 3572
<212> DNA
<213> Homo sapiens

<400> 1571
gccccagcag ccccagcccc agccccaggc ccagcagcag cagcagcagc ccctgctctc       60

ccgccgcccg gagaggctct gcagccatga agccaaccgt cccgaggcac cgccggtaag      120

cagggagcct ccgcggagct cccgccgccg ctcccccttg gtgagtcctg ccgcagcgag      180

aggcatggag aaggccgccc ccgcggggcg ctgatcccct cgccgcgccc gcgcgcacac      240

gccccccgcc gccgccgccg ctgccgccgc cgcgcgcccc cagtacctcg ctccccgccc      300

aggccccacc atgaccggct ccgcggccga cactcaccgc tgcccccacc ccaaaggcgc      360

caaaggcacc cggtcccgga gcagccacgc gcggcccgtg agcctcgcca ccagcggggg      420

ctcagaggag gaggacaaag acggcggggt gctgttccac gtcaacaaga gcggcttccc      480

catcgacagc cacacctggg agcgcatgtg gatgcacgtg gccaaggtgc accctaaggg      540

gggagaaatg gtgggcgcca tcaggaacgc cgccttcttg gcaaagcctt caatacccca      600

ggtcccaaac tacaggctgt cgatgacgat cccagactgg ctccaggcga tccagaatta      660

catgaagacc ctacactact taaccaatgg gcagccttcc attgagcggt tccccatcag      720

ctttaaaacc tacttctcag gaaactactt tcaccacgtt gtgctgggga tttactgcaa      780

tggccgctat ggctcattgg gcatgagccg cagggctgag ctgatggaca agccattgac      840

ttttcggact ctgagtgacc tcatctttga ctttgaggac tcttacaaga aatacctgca      900

cacagtcaag aaggtcaaga ttgggctgta cgtcccccat gagcctcata gcttccagcc      960

cattgagtgg aagcagctgg tcctcaacgt ctcaaagatg ctgagggctg acataaggaa     1020

ggagctggag aaatatgcca gggacatgag aatgaagatc ctgaaacctg caagtgccca     1080

ctctccgacc caagtgagaa gccggggaaa atccctgtcc cccagaagga gacaggcaag     1140

ccccccgagg aggctcggcc ggcgagagaa gtcgcctgca ctgcctgaaa agaaggtggc     1200

tgatctgagc actctgaatg aagtgggcta tcaaatccga atttagccaa gccataccgg     1260

ccagcaagag ggtttctgtg gtgcttctct ctgcacttta cccagcatct tcaggaggaa     1320

ctgcaactat ttattaagaa cttgtgaatt ttatttttaa ggattcacct ggaaatagaa     1380

tctgagtggg tggtaaccat tagctttaaa aaattcacta aaaggcacca tgaaaaggct     1440

gaagtaataa gccccactgg ggttggacta tgtccctcac tcaagatctt aaggataacc     1500

gtaactgaag ttttatattt ttccatttac ctactttctt ttacttgctt tgaacattat     1560

gcctcaccaa tagtaaatgt tcatgaaata atctcttgaa cttttggtat agtaaggtaa     1620

ctctaacagt attactgtct ttttcagcaa taacagaaag caaaaatggg tgggtttttt     1680

ttaagcagtt attacctcag cattttgaca tcagatatgc aaacttaatg gcgttttgtt     1740

tttttatatt ctatttgtat tctttcccca gtatttccca tggggatctc cacaagtttg     1800

gagttttttc ctggtgcaca cacgtgagga gatttaaggt actatatgca agtgttttac     1860

taaaaagcac tgaaattctt ctggcaatac aagaaccatt ttcaggatct tggagttact     1920

tccttcttaa tctttcttaa agcattcact gatgtttttg ttttttcaaa atgaaacaaa     1980

aatatcacat tgagaagcta gtctatgttc tgtcactaac atttaaactt tgcagactct     2040

aacaaaaagc acaagaggtc acgtactatt atacaaattt agcggtactg gatttacctc     2100

tgacattaac acactcaggc agagaccagg agtgatcagc aggtcttcag aaccaaaaaa     2160

cctttctgtt cacatttcat ctgattttta aactgaggca ggctttgatt cttctgaagg     2220

atgccaagaa tcaaactaag ggaggactca ctgttaaaga tgtgttctga tgtcttatat     2280

taagaccaaa tgtgacatga tgtgattatc ttccagtact ttgcttttag gtaccatttc     2340

atgacatttt aggaatgagt attggaaaat ataaagaatt agaaaagcag cacttttttt     2400

ttaatggaaa agtcttcggt ccagtgttac accttatagt gtaattcagt ccctaagcac     2460

agaatgaatg tctggcctgc atatggtagt tacagtgtaa cctctggctg cagaccacac     2520

aggacaaccc taacagccta gtcttgtatg gtgtaaatat caagagtaca gcttcaattt     2580

catttgcttt atcttagcaa caatgccaac tcaggagagc agacggccga tttcagtgaa     2640

gtctggtagt caacagatgt tatttcagtc tcagtgcatc tcctctggct ttctttgact     2700

gaaggtgttt ataggaagga agttaaaaaa aaaaaaagct cattgagatt ctttaccaat     2760

tctttacaag atttctgggg gtgacaggga aagcaaaagg acttcaaagc aaaagggtgc     2820

acaagagctt acttcaccct gaaaatcagt attattaatg aaaagtactg ttttcttaaa     2880

gaagtcgaat gtcctttaga tgaacaagac caagtataca tctccattag attaaaatgt     2940

agcacagggt taaaaattat cagtttaatc tctttaagaa cagtattatc agagtttaaa     3000

atgagttagc tctgtttatc tacacacagc aaacccattc gcagcctctt ggccacatgt     3060

attcagatgt ttgaaatagt gaatcatttc attttcattc taaaacaata ctgacttagc     3120

catatacctt ctgtttgtca atctgaaact tgcttacatc taataagtag acctcttata     3180

acactgcaac cattctaaga gttggaattt atttttgcca agtattaagt actgttacat     3240

ctaaaataca gaatgtcaaa tggttgcata gcttgtttcc cacaacaagg aggaaaagaa     3300

caggaataca aactctgtaa tatgctgata aagaagcctt agaactgcca actggcttga     3360

tggttcaatt agtaagctaa tttctcccac acccgctcct tgatttttag actaattttc     3420

ccaaagcaag gtttagtcac acaaacttga aagtacattt aaaatgttct tagttgtcat     3480

cctactttta ttgcctatgg aatatgctaa tttctaaaaa aaatacggga gaggcaccaa     3540

acccctaaat tctagtgcaa taatttaaaa aa                                   3572


<210> 1572
<211> 1369
<212> DNA
<213> Homo sapiens

<400> 1572
gttgcggtgg ccaatagacg cattcggaac atcggcggct gcccgggtga cttggttata       60

tgtcacagaa taacattcga gaatgggaca tggaatgagg cgacggcccc agcaagcccc      120

agcagcccca gccccagccc caggcccagc agcagcagca gcagcccctg ctctcccgcc      180

gcccggagag gctctgcagc catgaagcca accgtcccga ggcaccgccg gtaagcaggg      240

agcctccgcg gagctcccgc cgccgctccc ccttggtgac ctcgccacca gcgggggctc      300

agaggaggag gacaaagacg gcggggtgct gttccacgtc aacaagagcg gcttccccat      360

cgacagccac acctgggagc gcatgtggat gcacgtggcc aaggtgcacc ctaagggggg      420

agaaatggtg ggcgccatca ggaacgccgc cttcttggca aagccttcaa taccccaggt      480

cccaaactac aggctgtcga tgacgatccc agactggctc caggcgatcc agaattacat      540

gaagacccta caatataatc acacagggac ccagttcttt gaaattagga aaatgagacc      600

gctgagtggg ttaatggaaa cagcaaaaga aatgacccga gagtccttgc ctatcaaatg      660

ccttgaagct gtcatcctgg gcatctactt aaccaatggg cagccttcca ttgagcggtt      720

ccccatcagc tttaaaacct acttctcagg aaactacttt caccacgttg tgctggggat      780

ttactgcaat ggccgctatg gctcattggg catgagccgc agggctgagc tgatggacaa      840

gccattgact tttcggactc tgagtgacct catctttgac tttgaggact cttacaagaa      900

atacctgcac acagtcaaga aggtcaagat tgggctgtac gtcccccatg agcctcatag      960

cttccagccc attgagtgga agcagctggt cctcaacgtc tcaaagatgc tgagggctga     1020

cataaggaag gagctggaga aatatgccag ggacatgaga atgaagatcc tgaaacctgc     1080

aagtgcccac tctccgaccc aagtgagaag ccggggaaaa tccctgtccc ccagaaggag     1140

acaggcaagc cccccgagga ggctcggccg gcgagagaag tcgcctgcac tgcctgaaaa     1200

gaaggtggct gatctgagca ctctgaatga agtgggctat caaatccgaa tttagccaag     1260

ccataccggc cagcaagagg gtttctgtgg tgcttctctc tgcactttac ccagcatctt     1320

caggaggaac tgcaactatt tattaagaac ttgtgaattt tatttttaa                 1369


<210> 1573
<211> 1206
<212> DNA
<213> Homo sapiens

<400> 1573
agcagcagca gcagcagccc ctgctctccc gccgcccgga gaggctctgc agccatgaag       60

ccaaccgtcc cgagccttca ataccccagg tcccaaacta caggctgtcg atgacgatcc      120

cagactggct ccaggcgatc cagaattaca tgaagaccct acaatataat cacacaggga      180

cccagttctt tgaaattagg aaaatgagac cgctgagtgg gttaatggaa acagcaaaag      240

aaatgacccg agagtccttg cctatcaaat gccttgaagc tgtcatcctg ggcatctact      300

taaccaatgg gcagccttcc attgagcggt tccccatcag ctttaaaacc tacttctcag      360

gaaactactt tcaccacgtt gtgctgggga tttactgcaa tggccgctat ggctcattgg      420

gcatgagccg cagggctgag ctgatggaca agccattgac ttttcggact ctgagtgacc      480

tcatctttga ctttgaggac tcttacaaga aatacctgca cacagtcaag aaggtcaaga      540

ttgggctgta cgtcccccat gagcctcata gcttccagcc cattgagtgg aagcagctgg      600

tcctcaacgt ctcaaagatg ctgagggctg acataaggaa ggagctggag aaatatgcca      660

gggacatgag aatgaagatc ctgaaacctg caagtgccca ctctccgacc caagtgagaa      720

gccggggaaa atccctgtcc cccagaagga gacaggcaag ccccccgagg aggctcggcc      780

ggcgagagaa gtcgcctgca ctgcctgaaa agaaggtggc tgatctgagc actctgaatg      840

aagtgggcta tcaaatccga atttagccaa gccataccgg ccagcaagag ggtttctgtg      900

gtgcttctct ctgcacttta cccagcatct tcaggaggaa ctgcaactat ttattaagaa      960

cttgtgaatt ttatttttaa ggattcacct ggaaatagaa tctgagtggg tggtaaccat     1020

tagctttaaa aaattcacta aaaggcacca tgaaaaggct gaagtaataa gccccactgg     1080

ggttggacta tgtccctcac tcaagatctt aaggataacc gtaactgaag ttttatattt     1140

ttccatttac ctactttctt ttacttgctt tgaacattat gcctcaccaa tagtaaatgt     1200

tcatga                                                                1206


<210> 1574
<211> 4224
<212> DNA
<213> Homo sapiens

<400> 1574
attcgagaat gggacatgga atgaggcgac ggccccagca agccccagca gccccagccc       60

cagccccagg cccagcagca gcagcagcag cccctgctct cccgccgccc ggagaggctc      120

tgcagccatg aagccaaccg tcccgaggca ccgccggtaa gcagggagcc tccgcggagc      180

tcccgccgcc gctccccctt ggcgccaaag gcacccggtc ccggagcagc cacgcgcggc      240

ccgtgagcct cgccaccagc gggggctcag aggaggagga caaagacggc ggggtgctgt      300

tccacgtcaa caagagcggc ttccccatcg acagccacac ctgggagcgc atgtggatgc      360

acgtggccaa ggtgcaccct aaggggggag aaatggtggg cgccatcagg aacgccgcct      420

tcttggcaaa gccttcaata ccccaggtcc caaactacag gctgtcgatg acgatcccag      480

actggctcca ggcgatccag aattacatga agaccctaca atataatcac acagggaccc      540

agttctttga aattaggaaa atgagaccgc tgagtgggtt aatggaaaca gcaaaagaaa      600

tgacccgaga gtccttgcct atcaaatgcc ttgaagctgt catcctgggc atctacttaa      660

ccaatgggca gccttccatt gagcggttcc ccatcagctt taaaacctac ttctcaggaa      720

actactttca ccacgttgtg ctggggattt actgcaatgg ccgctatggc tcattgggca      780

tgagccgcag ggctgagctg atggacaagc cattgacttt tcggactctg agtgacctca      840

tctttgactt tgaggactct tacaagaaat acctgcacac agtcaagaag gtcaagattg      900

ggctgtacgt cccccatgag cctcatagct tccagcccat tgagtggaag cagctggtcc      960

tcaacgtctc aaagatgctg agggctgaca taaggaagga gctggagaaa tatgccaggg     1020

acatgagaat gaagatcctg aaacctgcaa gtgcccactc tccgacccaa gtgagaagcc     1080

ggggaaaatc cctgtccccc agaaggagac aggcaagccc cccgaggagg ctcggccggc     1140

gagagaagtc gcctgcactg cctgaaaaga aggtggctga tctgagcact ctgaatgaag     1200

tgggctatca aatccgaatt tagccaagcc ataccggcca gcaagagggt ttctgtggtg     1260

cttctctctg cactttaccc agcatcttca ggaggaactg caactattta ttaagaactt     1320

gtgaatttta tttttaagga ttcacctgga aatagaatct gagtgggtgg taaccattag     1380

ctttaaaaaa ttcactaaaa ggcaccatga aaaggctgaa gtaataagcc ccactggggt     1440

tggactatgt ccctcactca agatcttaag gataaccgta actgaagttt tatatttttc     1500

catttaccta ctttctttta cttgctttga acattatgcc tcaccaatag taaatgttca     1560

tgaaataatc tcttgaactt ttggtatagt aaggtaactc taacagtatt actgtctttt     1620

tcagcaataa cagaaagcaa aaatgggtgg gtttttttta agcagttatt acctcagcat     1680

tttgacatca gatatgcaaa cttaatggcg ttttgttttt ttatattcta tttgtattct     1740

ttccccagta tttcccatgg ggatctccac aagtttggag ttttttcctg gtgcacacac     1800

gtgaggagat ttaaggtact atatgcaagt gttttactaa aaagcactga aattcttctg     1860

gcaatacaag aaccattttc aggatcttgg agttacttcc ttcttaatct ttcttaaagc     1920

attcactgat gtttttgttt tttcaaaatg aaacaaaaat atcacattga gaagctagtc     1980

tatgttctgt cactaacatt taaactttgc agactctaac aaaaagcaca agaggtcacg     2040

tactattata caaatttagc ggtactggat ttacctctga cattaacaca ctcaggcaga     2100

gaccaggagt gatcagcagg tcttcagaac caaaaaacct ttctgttcac atttcatctg     2160

atttttaaac tgaggcaggc tttgattctt ctgaaggatg ccaagaatca aactaaggga     2220

ggactcactg ttaaagatgt gttctgatgt cttatattaa gaccaaatgt gacatgatgt     2280

gattatcttc cagtactttg cttttaggta ccatttcatg acattttagg aatgagtatt     2340

ggaaaatata aagaattaga aaagcagcac ttttttttta atggaaaagt cttcggtcca     2400

gtgttacacc ttatagtgta attcagtccc taagcacaga atgaatgtct ggcctgcata     2460

tggtagttac agtgtaacct ctggctgcag accacacagg acaaccctaa cagcctagtc     2520

ttgtatggtg taaatatcaa gagtacagct tcaatttcat ttgctttatc ttagcaacaa     2580

tgccaactca ggagagcaga cggccgattt cagtgaagtc tggtagtcaa cagatgttat     2640

ttcagtctca gtgcatctcc tctggctttc tttgactgaa ggtgtttata ggaaggaagt     2700

taaaaaaaaa aaaagctcat tgagattctt taccaattct ttacaagatt tctgggggtg     2760

acagggaaag caaaaggact tcaaagcaaa agggtgcaca agagcttact tcaccctgaa     2820

aatcagtatt attaatgaaa agtactgttt tcttaaagaa gtcgaatgtc ctttagatga     2880

acaagaccaa gtatacatct ccattagatt aaaatgtagc acagggttaa aaattatcag     2940

tttaatctct ttaagaacag tattatcaga gtttaaaatg agttagctct gtttatctac     3000

acacagcaaa cccattcgca gcctcttggc cacatgtatt cagatgtttg aaatagtgaa     3060

tcatttcatt ttcattctaa aacaatactg acttagccat ataccttctg tttgtcaatc     3120

tgaaacttgc ttacatctaa taagtagacc tcttataaca ctgcaaccat tctaagagtt     3180

ggaatttatt tttgccaagt attaagtact gttacatcta aaatacagaa tgtcaaatgg     3240

ttgcatagct tgtttcccac aacaaggagg aaaagaacag gaatacaaac tctgtaatat     3300

gctgataaag aagccttaga actgccaact ggcttgatgg ttcaattagt aagctaattt     3360

ctcccacacc cgctccttga tttttagact aattttccca aagcaaggtt tagtcacaca     3420

aacttgaaag tacatttaaa atgttcttag ttgtcatcct acttttattg cctatggaat     3480

atgctaattt ctaaaaaaaa tacgggagag gcaccaaacc cctaaattct agtgcaataa     3540

tttaaaaaac aaaaaacaaa acaaaacaaa aaacatgtta tatgcacccc cctcccaaag     3600

ctgattttaa gactggctag aattcaaaat ataaaaaata aaactatgaa gtgatttgaa     3660

atcggtttta aaaagttgtt agtgcaagag aaattttatg tttaagccat catggcaata     3720

tatgcaaagt ttaaatgaat gacagaaatc ttgattttag actgtatgtt gtgctgtttt     3780

gagtacactt tatttcggag atatttagta ttttctatac actctgaaat catgagcatt     3840

tcactttttc taagtcaatt atttcataag gattttatta atagatattg gtaaatagaa     3900

ctttggaaat cttaattcag aattcttact atacctgagt cttttgtaag ctatagtttt     3960

atgtacaacc ttgtacagtt tttttgacat acaattcaga actttgttta ttctcttgga     4020

ctttgttctg gccaatacat tttttttaaa tctttaagaa gaactgtgat tgttttagtg     4080

ggtatttttc taattaaatg aaaacttgta taatggtatt ttagagaatg ccagtaagtg     4140

catgtttcaa gttaatgttt ttctcatcac ttgtatgttt ctaacacagc atgggacttt     4200

aataaaacca tcctggaaac ttaa                                            4224


<210> 1575
<211> 1218
<212> DNA
<213> Homo sapiens

<400> 1575
agttccgacg aaaaatggcg gggtctcctg agttggtggt ccttgaccct ccatgggaca       60

aggagctcgc ggctggcaca gagagccagg ccttggtctc cgccactccc cgagaagact      120

ttcgggtgcg ctgcacctcg aagcgggctg tgaccgaaat gctacaactg tgcggccgct      180

tcgtgcaaaa gctcggggac gctctgccgg aggagattcg ggagcccgct ctgcgagatg      240

cgcagtggac ttttgaatca gctgtgcaag agaatatcag cattaatggg caagcatggc      300

aggaagcttc agataattgt tttatggatt ctgacatcaa agtacttgaa gatcagtttg      360

atgaaatcat agtagatata gccacaaaac gtaagcagta tcccagaaag atcctggaat      420

gtgtcatcaa aaccataaaa gcaaaacaag aaattctgtc cttgcctgca ttaattgaac      480

aaggagaggg attttcccaa gttctcagga tgcagcctgt tatccacctc cagaggattc      540

accaagaagt cttttccagt tgtcatagga aaccagatgc taaacctgag aactttataa      600

cacagataga aaccacacca acagagactg cttccaggaa aacctctgac atggtactga      660

aaagaaagca aactaaagac tgcccccaga gaaaatggta tccattgcgg ccaaagaaaa      720

ttaatcttga tacatgagct ctttctgttt attttgggag ttgaaaatag gcaccatcaa      780

catttagatt acagcctaat taatacctag ataagacttc atttgaaata agaaataact      840

cttttactag tgattcattt atacagatat agtatctctg tgcggggata tgatataata      900

ttgtatttcc ttactgtttt atctattgta aataaaaagc attttaaaaa gtattgacac      960

aaagcccatc agtgggcatt aaaaatatta aaagtgcaga cttttactgt ccttaagtgc     1020

catcaactct cagctccctt gtagcttttg tgggatttaa caagtaacaa attctgttgt     1080

gtttccctgg tatacatctt tctaggaaaa aaaaaaaaaa gagagagagc tgtataatga     1140

tttttcgttt acatgctgaa aagtaattat cagttctgca cagcagcaga tgcagggttt     1200

ttttttaaag atgtagtt                                                   1218


<210> 1576
<211> 722
<212> DNA
<213> Homo sapiens

<400> 1576
cccacagttc cgacgaaaaa tggcggggtc tcctgagttg gtggtccttg accctccatg       60

ggacaaggag ctcgcggctg gcacagagag ccaggccttg gtctccgcca ctccccgaga      120

agactttcgg gtgcgctgca cctcgaagcg ggctgtgacc gaaatgctac aactgtgcgg      180

ccgcttcgtg caaaagctcg gggacgctct gccggaggag attcgggagc ccgctctgcg      240

agatgcgcag tggacttttg aatcagctgt gcaagagaat atcagcatta atgggcaagc      300

atggcaggaa gcttcagata attgttttat ggattctgac atcaaagtac ttgaagatca      360

gtttgatgaa atcatagtag atatagccac aaaacgtaag cagtatccca gaaagatcct      420

ggaatgtgtc atcaaaacca taaaagcaaa acaagaaatt ctgaagcagt accaccctgt      480

tgtacatcca ctggacctaa aatatgaccc tgatccagtc cttgcctgca ttaattgaac      540

aaggagaggg attttcccaa gttctcagga tgcagcctgt tatccacctc cagaggattc      600

accaagaagt cttttccagt tgtcatagga aaccagatgc taaacctgag aactttataa      660

cacagataga aaccacacca acagagactg cttccaggaa aacctctgac atggtactga      720

aa                                                                     722


<210> 1577
<211> 2317
<212> DNA
<213> Homo sapiens

<400> 1577
cccacagttc cgacgaaaaa tggcggggtc tcctgagttg gtggtccttg accctccatg       60

ggacaaggag ctcgcggctg gcacagagag ccaggccttg gtctccgcca ctccccgaga      120

agactttcgg gtgcgctgca cctcgaagcg ggctgtgacc gaaatgctac aactgtgcgg      180

ccgcttcgtg caaaagctcg gggacgctct gccggaggag attcgggagc ccgctctgcg      240

agatgcgcag tggacttttg aatcagctgt gcaagagaat atcagcatta atgggcaagc      300

atggcaggaa gcttcagata attgttttat ggattctgac atcaaagtac ttgaagatca      360

gtttgatgaa atcatagtag atatagccac aaaacgtaag cagtatccca gaaagatcct      420

ggaatgtgtc atcaaaacca taaaagcaaa acaagaaatt ctgaagcagt accaccctgt      480

tgtacatcca ctggacctaa aatatgaccc tgatccagcc cctcatatgg aaaatttgaa      540

atgcagaggg gaaacagtag caaaggagat cagtgaagcc atgaagtcct tgcctgcatt      600

aattgaacaa ggagagggat tttcccaagt tctcaggatg cagcctgtta tccacctcca      660

gaggattcac caagaagtct tttccagttg tcataggaaa ccagatgcta aacctgagaa      720

ctttataaca cagatagaaa ccacaccaac agagactgct tccaggaaaa cctctgacat      780

ggtactgaaa agaaagcaaa ctaaagactg cccccagaga aaatggtatc cattgcggcc      840

aaagaaaatt aatcttgata catgagctct ttctgtttat tttgggagtt gaaaataggc      900

accatcaaca tttagattac agcctaatta atacctagat aagacttcat ttgaaataag      960

aaataactct tttactagtg attcatttat acagatatag tatctctgtg cggggatatg     1020

atataatatt gtatttcctt actgttttat ctattgtaaa taaaaagcat tttaaaaagt     1080

attgacacaa agcccatcag tgggcattaa aaatattaaa agtgcagact tttactgtcc     1140

ttaagtgcca tcaactctca gctcccttgt agcttttgtg ggatttaaca agtaacaaat     1200

tctgttgtgt ttccctggta tacatctttc taggaaaaaa aaaaaaaaga gagagagctg     1260

tataatgatt tttcgtttac atgctgaaaa gtaattatca gttctgcaca gcagcagatg     1320

cagggttttt ttttaaagat gtagtttgat ttatcaaatt aatgtgctga tgataatact     1380

ggctttgact ttgttactcc atgttcagct aatttaggtt tgtgagatta actttaggat     1440

tttttgttgt gtaagacaat gataactatt atttgtgcaa cattactctt tgaaataaaa     1500

attggcatgt agccaatgtt tcctgcccac actcactttt ttctatagac cattaacata     1560

atttgacttg gaactaatgg tttcttttta gggtttctta tttatttctt tacaaatcat     1620

tccagttcaa aatatatatc agattaatac actggcaaag tgtcattgtg ttattgaact     1680

atttcacatt tgaagatgtt tatatatcag gtatataatc actgggagaa gtctgagaaa     1740

acgatattgg ctttacttct aacatttaac tatagtttct tatagctctt attgtgtgtc     1800

ttacattata cagtgtaggc agggccatca aacttaccaa ctgtttcccc ttttgatgac     1860

tctgatacct tcattcattt ttcaaaggaa tttactgatc atgaggttgg aaaatctgta     1920

tttctcttgc ttattatgta ttaataatca taaatgtcta gattcaccag aagtcaccag     1980

aaggtctgtc tcagtgaaga aaacttataa agccactttg ttgcattttg tgtttcagtg     2040

ttacagtttg agatctgtat atttgtacac agctatgtgt ttttcattga aataatgtac     2100

aaagactgat cttgatgctg tgtattttta tgagttgtct taggcattcc tgagctcagc     2160

ttcagttgga tggtgggtca gcaccctgcg tttctgaaca tactagactt cagtttaaaa     2220

ctgttttgag gctgtataat atgttgctgt ttttacagtg ctaatgtttt tatagtatta     2280

aaattctgta tgatttgttt cacttcagag gtcccca                              2317


<210> 1578
<211> 1344
<212> DNA
<213> Homo sapiens

<400> 1578
ggacgctctg ccggaggaga ttcgggagcc cgctctgcga gatgcgcagt ggacttttga       60

atcagctgtg caagagaata tcagcattaa tgggcaagca tggcaggaag cttcagataa      120

ttgttttatg gattctgaca tcaaagtact tgaagatcag tttgatgaaa tcatagtaga      180

tatagccaca aaacgtaagc agtatcccag aaagatcctg gaatgtgtca tcaaaaccat      240

aaaagcaaaa caagaaattc tgaagcagta ccaccctgtt gtacatccac tggacctaaa      300

atatgaccct gatccaggag ccaagcctgg tggactagct ctaggggcag tttaggagag      360

aaggggatcg gggaaccttc atcccttctg cctctggtga actggcaaga tgaagaggat      420

gaagctgggt gacccagagc ccgccctccc tctctcggca gtcatctcca aggccggagt      480

agactggact ggagggcctc tgagaggaca cagccaggaa gcacactctc cctgtgctct      540

tcacccacca tgaagagaca ggacgggaaa gtccgtgctg tgctggtgtc catcagaggg      600

agggacacca tccagcccct gggaccgggc tcggctctgt tgttgcacag aagtcatttg      660

gagatcccca cgtgccacat ggaggattgt gggaggaccc caccgaggtg gctggcagcc      720

tctcatggac accatggaga gtgacccaat cactctgcat ttgaggactg cagagtggct      780

cagcggtctg gacattgaag aggagccaac ctcaggggta acacagtgcc gctgggagct      840

gagatgagcc aggtggtcgg tgggggacac aagcctagaa caaattcaat aaaccagcca      900

cagacgttat catcagatgt gcccagagac aaggtggaca ggggcatttg ctgtggagac      960

cagagggcca gagagagtac agggacctgg atagatggct ccagcacctc ttcttctccc     1020

tacacccata tgccatcttg ataaacagca gggaaatctg aaaaatacca agtcttccca     1080

tagggacagt gttacctccc aaaaactgtt tgaataattg gcttgaactg gattttctga     1140

actgaactaa tgctattgtt ttgtgggttt ttttcttcct actgagtaga gtagttgttt     1200

atgggggaca tctgatcctt tcattttctt ccagagagct aaccacctgt tctgacacca     1260

tttattgaat agtacctctt ttcccccact gatgtgagag gctgcatttt tcatctaata     1320

aaatcgaata tatatttaga tcta                                            1344


<210> 1579
<211> 774
<212> DNA
<213> Homo sapiens

<400> 1579
gggagccgga ggggacgcgc cggaggaaag atggaagact accaggctgc ggaggagact       60

gcttttgttg ttgatgaagt gagcaacatt gtaaaagagg ctatagaaag cgcaattggt      120

ggtaacgctt atcaacacag caaagtgaac cagtggacca caaatgtagt agaacaaact      180

ttaagccaac tcaccaagct gggaaaacca tttaaataca tcggtaatgg agtcttgttt      240

cttttatatt tgcgggatgg ttttttaaca ctgatcagag gggcatccag taccagaaac      300

aacagctaac gtggctcaac tcaaggaagg ctcctggtgg gagtcggtcg tgtgtgtagt      360

atacgttagc gtacgcttga ccatttggct gctggtacaa ttgcagatcg tatgtgaagc      420

gggatcttac aggaggtccc atcagatgct tttagaacaa gtgaagcata gaggaagtgt      480

ggacagcccc cagctgacag tggctcaact tagaattttt caactttgat ggatttacca      540

gggtattaag tgcatttgca acttacattt tcatatattg ttgatttatg atgggtttat      600

gggatgttgt aagtcaagga gcacctataa tttgtcaata tagtgagaca aggcaatctg      660

tccctataat ttttatcgag aacatcaacc acgtggagct acatacattg tacgtttgct      720

aaaagtggac agaatgacat ttgtgttacc cagtagactt ctctaacaaa aatt            774


<210> 1580
<211> 2891
<212> DNA
<213> Homo sapiens

<400> 1580
ttttcgtact gtaaccatat gggaggtgat acagtgcctt tcctttgtga ttaaggtcac       60

ggtagtcact tggaaggatc ctttaagctt ccagaaatga cttaatctct aagatattgc      120

aaattgttct tcactcagtg agttggtttt gtttccaagt ccgacttctg agtacagcaa      180

gtgaggtggc ttcgggcagt cagctcctga accccctaaa aagaaagggc agggcctgca      240

gtggacagca gccagacagg gaggaagact cactgccaag tcagggttct ctgccttgat      300

tccctcagga tgcacgttga ctgagggccc caggggttgc cctctcgaag gcgtgtccag      360

agctacgtac ctttcctggg actcagcagt aactttaaac gcttgtgctc atgtgaagag      420

cacattggca ggcaagtgcc tgactaatgt tattttcagg atgacctttt acccattcag      480

atctaccatg tgtaaaagga aaactatact cctggcacta gattcctgca ggcagcccac      540

ctcctgagtc atccagacac tgacagagaa cagccatgct ggcagctggt ggttagtcct      600

ggagtcggag ggcagcactg ggaaagaaaa ataattacct ggagataatg taatcatcgt      660

acattttaca agtaatggtg ctttaaaaaa atctcctcaa ggtcaaactg atcctcctaa      720

tcagtttaca tcatggaaga gagaattaca tcttaaatgg attacttcag cagcttcagt      780

taatttatac aaaaatcaac caactcatta agcctctcta ttggttaatg attctagcag      840

ccagttgaaa tggaagaaga gaatgaattc tagtttaaag tgaagtctta gattgtggca      900

tgattaaaac aaaacagggc caggtgtggt ggcttacgcc tgtaatccca gcattttggg      960

aggctgaggc gggaggatca cctgaggtca ggagttcgag accagcctgg ccaacatgat     1020

gaaaccccat ctctactaaa aatacgaaaa ttagccgggt gtggtggagg gcacctgtaa     1080

tcccagctac ttgggaggct gaggcaggag aatcacttga acctgggagg cagagattgc     1140

agtgagctga gattgcgcca ctgcattcca gcctgggcta cagagcgaca ctccgtctca     1200

aaaataaata aataaaaata aaacaatacc tttaaattat gtgcatgtat tctagtcttc     1260

tggtttctga agactgtaat gccatccttg gtaaagctga acagtctagt tagattattt     1320

ctaaggtctt catttctaca ttatgttcat tacctacatt tgcatttatc aatgtagtgg     1380

aaatatcttt taaataaatc aaacttaact gaatgttctt ccttacagac tgcttttgtt     1440

gttgatgaag tgagcaacat tgtaaaagag gctatagaaa gcgcaattgg tggtaacgct     1500

tatcaacaca gcaaagtgaa ccagtggacc acaaatgtag tagaacaaac tttaagccaa     1560

ctcaccaagc tgggaaaacc atttaaatac atcggtaatg gagtcttgtt tcttttatat     1620

ttgcgggatg gttttttaac actgatcaga ggggcatcca gtaccagaaa caacagctaa     1680

cgtggctcaa ctcaaggaag gctcctggtg ggagtcggtc gtgtgtgtag tatacgttag     1740

cgtacgcttg accatttggc tgctggtaca attgcagatc gtatgtgaag cgggatctta     1800

caggaggtcc catcagatgc ttttagaaca agtgaagcat agaggaagtg tggacagccc     1860

ccagctgaca gtggctcaac ttagaatttt tcaactttga tggatttacc agggtattaa     1920

gtgcatttgc aacttacatt ttcatatatt gttgatttat gatgggttta tgggatgttg     1980

taagtcaagg agcacctata atttgtcaat atagtgagac aaggcaatct gtccctataa     2040

tttttatcga gaacatcaac cacgtggagc tacatacatt gtacgtttgc taaaagtgga     2100

cagaatgaca tttgtgttac ccagtagact tctctaacaa aaatttgttt taacttaagt     2160

gacctgtgta attatgcaga agaatggagc tggattacac acagcaagtt cctgcttctg     2220

ggacagctct actgacggta tgattttcat tcatgtttgt gaagttttgt tgtgtgaaat     2280

atatgactgg aagtttccta tctttgaatg caatgcatgt ttatcacctt ttaaaacatt     2340

taataataga cttgccaagg ttctttgtgt agcatagaga tgggtacttg aatgttggcc     2400

ttattgtgag taaaacgtcg tcccccagct ttccctgccg taaatgctgc tctcttccct     2460

cccgcaggga gctgcactgt gcgatgggag aataagacca tgtactgcat cgtcagtgcc     2520

ttcggactgt ctatttgacc tgcagtccag cctatggcct ttctcctttt gtctctagtt     2580

catcctctaa ccaccagcca tgaattcagt gaactctttt ctcattctct ttgttttgtg     2640

gcactttcac aatgtagagg aaaaaaccaa atgaccgcac tgtgatgtga atggcaccga     2700

agtcagatga gtatccctgt aggtcacctg cagcctgcgt tgccacttgt cttaactctg     2760

aatatttcat ttcaaaggtg ctaaaatctg aaatctgcta gtgtgaaact tgctctactc     2820

tctgaaatga ttcaaataca ctaattttcc atactttata cttttgttag aataaattat     2880

tcaaatctaa a                                                          2891


<210> 1581
<211> 726
<212> DNA
<213> Homo sapiens

<400> 1581
agggagccgg aggggacgcg ccggaggaaa gatggaagac taccaggctg cggaggagac       60

tgcttttgtt gttgatgaag tgagcaacat tgtaaaagag gctatagaaa gcgcaattgg      120

tggtaacgct tatcaacaca gcaaagtgaa ccagtggacc acaaatgtag tagaacaaac      180

tttaagccaa ctcaccaagc tgggaaaacc atttaaatac atcgtgacct gtgtaattat      240

gcagaagaat ggagctggat tacacacagc aagttcctgc ttctgggaca gctctactga      300

cgggagctgc actgtgcgat gggagaataa gaccatgtac tgcatcgtca gtgccttcgg      360

actgtctatt tgacctgcag tccagcctat ggcctttctc cttttgtctc tagttcatcc      420

tctaaccacc agccatgaat tcagtgaact cttttctcat tctctttgtt ttgtggcact      480

ttcacaatgt agaggaaaaa accaaatgac cgcactgtga tgtgaatggc accgaagtca      540

gatgagtatc cctgtaggtc acctgcagcc tgcgttgcca cttgtcttaa ctctgaatat      600

ttcatttcaa aggtgctaaa atctgaaatc tgctagtgtg aaacttgctc tactctctga      660

aatgattcaa atacactaat tttccatact ttatactttt gttagaataa attattcaaa      720

tctaaa                                                                 726


<210> 1582
<211> 5170
<212> DNA
<213> Homo sapiens

<400> 1582
gaaattttaa tttattattc cccccctttt ttcctgcatc tataggataa tattgtaaaa       60

tagcaattga aaccaataat tattaaataa atatcaagga aaatccaagc aaagctttct      120

ttttgttgga ctagtggtgt ggtgtttgga gacagtctct gaatgtgaac aggaaagcac      180

ccatcagcaa aacactatca ctctctaggg agacagctgg gggaatctga ctctggcttc      240

tgcttttgtt ttaagggatt aacttccctg tcaagtccaa gaagacttgc gtatgagaag      300

attacctgat ggacttaatt ctaagattag cttttttcat caagatggaa aaagatcttt      360

aggagcagaa aaggggagtg ctaactgggg gagcgagaag ggagacgagc aaaagaaaca      420

aaatcttgcc acgtggctct gttttgtcag caagaggatt taagactcac ccagggcaaa      480

cactgggacc actgtaagag cgctggaaca ttctgcctct tgagtgaagg ggccttcttt      540

ctagcctcta tggcactgag gggtgcgccg gctggtggag gagcagtccg atggagccct      600

gcgttccccg gggacacagg gccaagcttt gaggtggaaa gtttctggtt ctgaaacaac      660

aaggagagag tctgtttttc ttcctaaaat ttggactctt gtctgcacaa actctggtct      720

gttttgcacg gtttgtgtgc ctttttttcc ctttatgcaa tctttttcag ctttagcagc      780

agaaatttgt ctagttcagg aaacatgcta gagggtggct tcagaaggaa gatgatcctg      840

tgtattctgt ctctgcatcc gaacttttga agagaaaaat tcgagctaga gggattctta      900

aagccttaag ttacttgaaa tctatgtatt tgcaaccctt tgtctctgga atcatattac      960

actaaactgg aatctcaggc tgaatgagaa taaccaagtg gagtaaaaag aagaaaaccg     1020

tttcttgatc accacttaat taacgatgct ctttctccaa aggatcagca cgttcttcct     1080

ctgagaactt gaaaatacaa atggacccca tgttttttta agcattacct tttcttagaa     1140

gactgccatc atcttttata gaggaatttt ttcactatgc attcggtgga tctttataaa     1200

atactgacct tctaattaga ttcaggtcag tcttaattaa agggggaaaa aagcaacgca     1260

agccaaccac aaaaacacat ataccaatga aagaaattgg tttaaatttc acagcattaa     1320

cattactttt taagtaaaac agttcattga agaaagtatg tatgcagcag tggaacatgg     1380

gcctgtgctt tgcagcgatt ccaacatcct gtgcctgtcc tggaaggggc gtgtccccaa     1440

gagtgagaag gagaagcctg tgtgcaggag acgctactat gaggaaggct ggctggccac     1500

gggcaacggg cgaggagtgg ttggggtgac tttcacctct agtcactgtc gcagggacag     1560

gagtactcca cagaggataa atttcaacct ccggggccac aatagcgagg ttgtgctggt     1620

gaggtggaat gagccctacc agaaactggc cacgtgcgat gcggacggag gcatattcgt     1680

gtggattcag tacgagggca ggtggtctgt ggagctggtc aacgaccgcg gggcgcaggt     1740

gagtgatttc acgtggagcc atgatggaac tcaagcactt atttcctatc gagatgggtt     1800

tgtcctggtt gggtctgtca gtggacaaag acactggtca tccgaaatca acttggaaag     1860

tcaaattacg tgtggcatat ggactcctga cgaccaacag gtgctgtttg gcacggccga     1920

tgggcaggtg attgtcatgg attgccacgg cagaatgctg gcccacgtcc tcttgcacga     1980

gtcagacggt gtcctcggca tgtcctggaa ctacccgatc ttcctggtgg aggacagcag     2040

cgagagcgac acggactcag atgactacgc ccctccccaa gatggtccgg cagcatatcc     2100

catcccagtg cagaacatca agcctctgct caccgtcagc ttcacctcgg gagacatcag     2160

cttaatgaac aactacgatg acttgtctcc cacggtcatc cgctcagggc tgaaagaggt     2220

ggtagcccag tggtgcacac agggggactt gctggcagtc gctgggatgg aacggcagac     2280

ccagcttggt gagcttccca atggtcccct tctgaagagt gccatggtca agttctacaa     2340

tgttcgtggg gagcacatct tcacactgga cactctcgtg cagcgcccca tcatctccat     2400

ctgctggggt caccgggatt cgaggctgtt gatggcatca ggaccagccc tgtacgtggt     2460

gcgtgtggag caccgggtgt ccagcctgca gctgctgtgc cagcaggcca tcgccagcac     2520

cttgcgtgag gacaaggacg tcagcaagct gactctgccc ccccgcctct gctcctacct     2580

ctccactgcc ttcatcccca ccatcaagcc cccaattcca gatccgaaca acatgagaga     2640

ctttgtcagc tacccatcag ccggcaacga gcggctgcac tgcaccatga agcgcacaga     2700

ggacgacccg gaggtgggcg gcccgtgcta cacgctctac ctggagtacc tgggcgggct     2760

tgtgcccatc ctcaaagggc ggcgcatcag caagctgcgg ccagagttcg tcatcatgga     2820

cccgcggaca gatagcaaac cagatgaaat ctatgggaac agcttgattt ctactgtgat     2880

cgacagctgc aactgctcag actccagtga cattgagctg agtgatgact gggctgccaa     2940

gaaatctccc aaaatctcca gagctagcaa atcacccaaa ctcccaagga tcagcattga     3000

ggcccgcaag tcacccaagc tgccccgggc tgctcaggag ctctcccggt ccccacggtt     3060

gcccctgcgc aagccctctg tgggctcgcc cagcctgact cggagagagt ttccttttga     3120

agacatcact cagcacaact atcttgctca ggtcacgtct aatatctggg gaaccaaatt     3180

taagattgtg ggcttggctg ctttcctgcc aaccaacctc ggtgcagtaa tctataaaac     3240

cagcctcctg catctccagc cgcggcagat gaccatttat ctcccagaag ttcggaaaat     3300

ttccatggac tatattaatt tacctgtctt caacccaaat gttttcagtg aagatgaaga     3360

tgatttacca ggtgatgcag tttggacgga ttgatggcag tgcgtacatt ctagacttcc     3420

agtatccgtt ctcagccgtg caggcctttg cagttgccct ggccaacgtg actcagcgcc     3480

tcaaatgaag agactggtgt ggggaggaga gagatgcaga gagcctttgg aagaggtctt     3540

cggagatgcc agaggagccc tctaggggtc cgatgcctgg gaggaccaga agccaacagc     3600

aaaactggaa aagcccggca ggcccaggag agggcgctga cctgtggtcg tcatttattt     3660

ggttgggttt tattaccttt tattgtctgt tcttcttttc ttctttcatt tcagtggcat     3720

ttggaagcaa agagtgctag gcacctgctg ttctttcagg aaacagcttg gctgtggtaa     3780

tgctctactg ggcccttcag aatgaagaca gtctgcctta gagcctgcta ttcttttaga     3840

catagggagg atgcattatc ctgtattctc ctccaacatc accactagcg taaaagcaaa     3900

aagcttttac aaaacacagc caaaaattct caagatgcag gttcttgggg aatgggatgg     3960

ggacagcatt tgatttacac tgattatgtt actccccaaa aggtgactta attaataaag     4020

ggcatttggg cagacacact gtgttggacc aacaaagtag gctctttaca ggggtgttct     4080

caccaggtag aaatgcgatt tgctcactga ggatgttggg gaagggacga agggtaaaga     4140

agaaactgca cgtatacaca ggttcacatc actctgcaga cagcaatgtg actcagcgtg     4200

tgacttgtag cagcagtacg agggctacac tcctctgctg aggatgtcta cattgaaagc     4260

ctccactagt ttcatcgttt gtcaaagttc cgtaggatca gtgatggtca ttcagcatga     4320

ctggttctgg gagaaggtga gagacaaaaa tggaaagatc ctggcctgtg gtagtggtag     4380

cagttttctc aaataatgtg gtgacagtca ctagatcctc acatgctgag aaacagcctc     4440

tactctctct gcccctttta ctttttaatc tggaatgcat tactgtaaac atgatctttc     4500

ccatgagata ccatgttcta tgccttccca ttctaaaagt gtggacaacg cttgatttga     4560

aaccactcct tttctcctct tggctacatt aaaattcagt tgactacaaa tgctttctat     4620

caaattagaa atgtaaccaa aaaaatgtta agtgttcacc agggtattaa aatacagagg     4680

agtatggtca aatctttgac aaaattttca tgatcttctc taacaaaaaa agttgtttat     4740

taactgtaca gactgtttac taaggagcta aaccactgag aaaacgttat taaaattgta     4800

atacctaggt agttggttga tcacagtttg ttaattgtat aaaaaaaaat tacctagaat     4860

atctcttccc acttcctcgt cctcgtgaga acctgtgggc agtattcaag ccctgatgac     4920

aaaacccagt gttttttgtt gttgtttttt gttgttgttt tttgtttttg tttttgtttt     4980

tctcagtctt acctgtgatg ttgtttagga tcaggcccct ctcctgggcc tgctgtgcag     5040

gagcacagga actatctgct ggcgttgggt tccaaatttg cattttattt ggaaacagac     5100

aagtagaaga tgctacagaa aagtattttc aaatttaaac gttttttaat cccctgtttt     5160

agttaaaaaa                                                            5170


<210> 1583
<211> 11123
<212> DNA
<213> Homo sapiens

<400> 1583
gaaattttaa tttattattc cccccctttt ttcctgcatc tataggataa tattgtaaaa       60

tagcaattga aaccaataat tattaaataa atatcaagga aaatccaagc aaagctttct      120

ttttgttgga ctagtggtgt ggtgtttgga gacagtctct gaatgtgaac aggaaagcac      180

ccatcagcaa aacactatca ctctctaggg agacagctgg gggaatctga ctctggcttc      240

tgcttttgtt ttaagggatt aacttccctg tcaagtccaa gaagacttgc gtatgagaag      300

attacctgat ggacttaatt ctaagattag cttttttcat caagatggaa aaagatcttt      360

aggagcagaa aaggggagtg ctaactgggg gagcgagaag ggagacgagc aaaagaaaca      420

aaatcttgcc acgtggctct gttttgtcag caagaggatt taagactcac ccagggcaaa      480

cactgggacc actgtaagag cgctggaaca ttctgcctct tgagtgaagg ggccttcttt      540

ctagcctcta tggcactgag gggtgcgccg gctggtggag gagcagtccg atggagccct      600

gcgttccccg gggacacagg gccaagcttt gaggtggaaa gtttctggtt ctgaaacaac      660

aaggagagag tctgtttttc ttcctaaaat ttggactctt gtctgcacaa actctggtct      720

gttttgcacg gtttgtgtgc ctttttttcc ctttatgcaa tctttttcag ctttagcagc      780

agaaatttgt ctagttcagg aaacatgcta gagggtggct tcagaaggaa gatgatcctg      840

tgtattctgt ctctgcatcc gaacttttga agagaaaaat tcgagctaga gggattctta      900

aagccttaag ttacttgaaa tctatgtatt tgcaaccctt tgtctctgga atcatattac      960

actaaactgg aatctcaggc tgaatgagaa taaccaagtg gagtaaaaag aagaaaaccg     1020

tttcttgatc accacttaat taacgatgct ctttctccaa aggatcagca cgttcttcct     1080

ctgagaactt gaaaatacaa atggacccca tgttttttta agcattacct tttcttagaa     1140

gactgccatc atcttttata gaggaatttt ttcactatgc attcggtgga tctttataaa     1200

atactgacct tctaattaga ttcaggtcag tcttaattaa agggggaaaa aagcaacgca     1260

agccaaccac aaaaacacat ataccaatga aagaaattgg tttaaatttc acagcattaa     1320

cattactttt taagtaaaac agttcattga agaaagtatg tatgcagcag tggaacatgg     1380

gcctgtgctt tgcagcgatt ccaacatcct gtgcctgtcc tggaaggggc gtgtccccaa     1440

gagtgagaag gagaagcctg tgtgcaggag acgctactat gaggaaggct ggctggccac     1500

gggcaacggg cgaggagtgg ttggggtgac tttcacctct agtcactgtc gcagggacag     1560

gagtactcca cagaggataa atttcaacct ccggggccac aatagcgagg ttgtgctggt     1620

gaggtggaat gagccctacc agaaactggc cacgtgcgat gcggacggag gcatattcgt     1680

gtggattcag tacgagggca ggtggtctgt ggagctggtc aacgaccgcg gggcgcaggt     1740

gagtgatttc acgtggagcc atgatggaac tcaagcactt atttcctatc gagatgggtt     1800

tgtcctggtt gggtctgtca gtggacaaag acactggtca tccgaaatca acttggaaag     1860

tcaaattacg tgtggcatat ggactcctga cgaccaacag gtgctgtttg gcacggccga     1920

tgggcaggtg attgtcatgg attgccacgg cagaatgctg gcccacgtcc tcttgcacga     1980

gtcagacggt gtcctcggca tgtcctggaa ctacccgatc ttcctggtgg aggacagcag     2040

cgagagcgac acggactcag atgactacgc ccctccccaa gatggtccgg cagcatatcc     2100

catcccagtg cagaacatca agcctctgct caccgtcagc ttcacctcgg gagacatcag     2160

cttaatgaac aactacgatg acttgtctcc cacggtcatc cgctcagggc tgaaagaggt     2220

ggtagcccag tggtgcacac agggggactt gctggcagtc gctgggatgg aacggcagac     2280

ccagcttggt gagcttccca atggtcccct tctgaagagt gccatggtca agttctacaa     2340

tgttcgtggg gagcacatct tcacactgga cactctcgtg cagcgcccca tcatctccat     2400

ctgctggggt caccgggatt cgaggctgtt gatggcatca ggaccagccc tgtacgtggt     2460

gcgtgtggag caccgggtgt ccagcctgca gctgctgtgc cagcaggcca tcgccagcac     2520

cttgcgtgag gacaaggacg tcagcaagct gactctgccc ccccgcctct gctcctacct     2580

ctccactgcc ttcatcccca ccatcaagcc cccaattcca gatccgaaca acatgagaga     2640

ctttgtcagc tacccatcag ccggcaacga gcggctgcac tgcaccatga agcgcacaga     2700

ggacgacccg gaggtgggcg gcccgtgcta cacgctctac ctggagtacc tgggcgggct     2760

tgtgcccatc ctcaaagggc ggcgcatcag caagctgcgg ccagagttcg tcatcatgga     2820

cccgcggaca gatagcaaac cagatgaaat ctatgggaac agcttgattt ctactgtgat     2880

cgacagctgc aactgctcag actccagtga cattgagctg agtgatgact gggctgccaa     2940

gaaatctccc aaaatctcca gagctagcaa atcacccaaa ctcccaagga tcagcattga     3000

ggcccgcaag tcacccaagc tgccccgggc tgctcaggag ctctcccggt ccccacggtt     3060

gcccctgcgc aagccctctg tgggctcgcc cagcctgact cggagagagt ttccttttga     3120

agacatcact cagcacaact atcttgctca ggtcacgtct aatatctggg gaaccaaatt     3180

taagattgtg ggcttggctg ctttcctgcc aaccaacctc ggtgcagtaa tctataaaac     3240

cagcctcctg catctccagc cgcggcagat gaccatttat ctcccagaag ttcggaaaat     3300

ttccatggac tatattaatt tacctgtctt caacccaaat gttttcagtg aagatgaaga     3360

tgatttacca gtgacaggag catctggtgt ccctgagaac agcccacctt gtaccgtgaa     3420

catccctatt gcaccgatcc acagctcggc tcaggctatg tcccccacgc agagcatagg     3480

gctggtgcag tccctactgg ccaatcagaa tgtgcagcta gatgtcctga ccaaccagac     3540

gacagctgta gggacagcag aacatgcagg tgacagtgcc acccagtacc cagtctccaa     3600

ccggtactcc aatcctggac aggtgatttt cggaagcgtg gaaatgggcc gcatcattca     3660

gaacccccct ccactgtccc tgcctccccc gccgcagggg cccatgcagc tgtccacggt     3720

gggccatgga gaccgagacc acgaacacct gcagaagtca gccaaggccc tgcggccaac     3780

accgcagctg gcagctgagg gggacgcagt ggtctttagt gccccccagg aggtccaggt     3840

gacgaagata aaccctccac ccccgtaccc aggaaccatc cccgctgccc ccaccacagc     3900

agcacccccg ccccctctgc cgcccccaca gcccccagtg gatgtgtgct tgaagaaggg     3960

cgacttctcc ctctacccca cgtcagtgca ctaccagacc cccctgggct atgagaggat     4020

caccaccttc gacagcagtg gcaacgtgga ggaggtgtgc cggccccgca cccggatgct     4080

gtgctcccag aacacgtaca ccctccccgg cccgggtagc tctgccacct tgaggctcac     4140

ggccactgag aagaaggtcc ctcagccctg cagcagtgcc accctgaacc gcctgaccgt     4200

ccctcgctac tccatcccca ccggggaccc acccccgtat cctgaaattg ccagccagct     4260

ggcccagggg cggggggctg cccagaggtc cgacaatagc ctcatccacg ctaccctgcg     4320

gaggaacaac cgtgaggcta cgctcaagat ggcccagctg gccgacagcc cgcgggcccc     4380

cctgcagccc ctggccaagt ccaagggcgg gcccgggggg gtggtgacac agctcccagc     4440

gcggccccca cctgccctgt acacctgcag tcagtgcagt ggcacagggc ccagctcaca     4500

gcccggagcc tccctggccc ataccgccag cgcctccccg ttggcctccc agtcctccta     4560

cagcctcctg agcccacccg acagcgcccg cgaccgcacc gactacgtca actcggcctt     4620

cacggaggac gaggccctgt cccagcactg tcagcttgag aagcccttga ggcaccctcc     4680

cctgcctgaa gctgctgtca ccctgaaacg gccaccccct taccagtggg accccatgct     4740

gggtgaggat gtttgggttc ctcaagaaag gacagcacag acttcagggc ccaacccctt     4800

aaaactgtcc tctctgatgc tgagtcaggg ccagcacctg gacgtgtccc gactgccctt     4860

catctccccc aagtctcctg ccagccccac tgccactttc caaacaggct atgggatggg     4920

agtgccatat ccaggaagct ataacaaccc ccctttgcct ggagtgcagg ctccctgctc     4980

tcccaaagat gccctgtccc caacgcagtt tgcacaacag gagcctgctg tggtccttca     5040

gccgctgtac ccacccagcc tctcctattg caccctgccc cccatgtacc caggaagcag     5100

cacgtgctct agtttacagc tgccacctgt cgccttgcat ccatggagtt cctacagcgc     5160

ctgcccgccc atgcagaacc cccagggcac tctcccccca aagccacact tggtggtgga     5220

gaagcccctt gtgtccccac cacctgccga cctccaaagc cacttgggca cagaggtgat     5280

ggtagagact gcagacaact tccaggaagt cctctccctg accgaaagcc cagtccccca     5340

gcggacagaa aaatttggaa agaagaaccg gaagcgcctg gacagccgag cagaagaagg     5400

cagcgttcag gccatcactg agggcaaagt gaagaaggag gctaggactt tgagtgactt     5460

taattcccta atctccagcc cacacctggg gagagagaag aagaaagtga agagtcagaa     5520

agaccaactg aagtcaaaga agttgaataa gacaaacgag ttccaggaca gctccgagag     5580

cgagcctgag ctgttcatca gcggggatga gctcatgaac cagagccagg gcagcagaaa     5640

gggctggaaa agcaagcgct ccccacgggc cgccggcgag ctggaggagg ccaagtgccg     5700

gcgggccagt gagaaggagg acgggcggct gggcagccaa ggcttcgtgt acgtgatggc     5760

caacaagcag ccgctgtgga acgaggccac ccaggtctac cagctggact tcggggggcg     5820

ggtgacccag gagtccgcca agaacttcca gattgagtta gaggggcggc aggtgatgca     5880

gtttggacgg attgatggca gtgcgtacat tctagacttc cagtatccgt tctcagccgt     5940

gcaggccttt gcagttgccc tggccaacgt gactcagcgc ctcaaatgaa gagactggtg     6000

tggggaggag agagatgcag agagcctttg gaagaggtct tcggagatgc cagaggagcc     6060

ctctaggggt ccgatgcctg ggaggaccag aagccaacag caaaactgga aaagcccggc     6120

aggcccagga gagggcgctg acctgtggtc gtcatttatt tggttgggtt ttattacctt     6180

ttattgtctg ttcttctttt cttctttcat ttcagtggca tttggaagca aagagtgcta     6240

ggcacctgct gttctttcag gaaacagctt ggctgtggta atgctctact gggcccttca     6300

gaatgaagac agtctgcctt agagcctgct attcttttag acatagggag gatgcattat     6360

cctgtattct cctccaacat caccactagc gtaaaagcaa aaagctttta caaaacacag     6420

ccaaaaattc tcaagatgca ggttcttggg gaatgggatg gggacagcat ttgatttaca     6480

ctgattatgt tactccccaa aaggtgactt aattaataaa gggcatttgg gcagacacac     6540

tgtgttggac caacaaagta ggctctttac aggggtgttc tcaccaggta gaaatgcgat     6600

ttgctcactg aggatgttgg ggaagggacg aagggtaaag aagaaactgc acgtatacac     6660

aggttcacat cactctgcag acagcaatgt gactcagcgt gtgacttgta gcagcagtac     6720

gagggctaca ctcctctgct gaggatgtct acattgaaag cctccactag tttcatcgtt     6780

tgtcaaagtt ccgtaggatc agtgatggtc attcagcatg actggttctg ggagaaggtg     6840

agagacaaaa atggaaagat cctggcctgt ggtagtggta gcagttttct caaataatgt     6900

ggtgacagtc actagatcct cacatgctga gaaacagcct ctactctctc tgcccctttt     6960

actttttaat ctggaatgca ttactgtaaa catgatcttt cccatgagat accatgttct     7020

atgccttccc attctaaaag tgtggacaac gcttgatttg aaaccactcc ttttctcctc     7080

ttggctacat taaaattcag ttgactacaa atgctttcta tcaaattaga aatgtaacca     7140

aaaaaatgtt aagtgttcac cagggtatta aaatacagag gagtatggtc aaatctttga     7200

caaaattttc atgatcttct ctaacaaaaa aagttgttta ttaactgtac agactgttta     7260

ctaaggagct aaaccactga gaaaacgtta ttaaaattgt aatacctagg tagttggttg     7320

atcacagttt gttaattgta taaaaaaaaa ttacctagaa tatctcttcc cacttcctcg     7380

tcctcgtgag aacctgtggg cagtattcaa gccctgatga caaaacccag tgttttttgt     7440

tgttgttttt tgttgttgtt ttttgttttt gtttttgttt ttctcagtct tacctgtgat     7500

gttgtttagg atcaggcccc tctcctgggc ctgctgtgca ggagcacagg aactatctgc     7560

tggcgttggg ttccaaattt gcattttatt tggaaacaga caagtagaag atgctacaga     7620

aaagtatttt caaatttaaa cgttttttaa tcccctgttt tagttaaaaa attggaaaag     7680

aaaccgaccc atttttttcc cagatcaaga tgacatgaca tcactcccaa ttctctccaa     7740

accccagaga aatactgacg aagttttctg atgtggcaaa ggatatttcc catctaatac     7800

cagtttctca tttatattta acgtattgga cctgatattt ttagtgggtg cattcttcca     7860

gaaagaattc agcaatgtta tcagaattaa ttcttttata tgagtttatg tagcttgata     7920

tggtgtttca gtgcttattg gttgtgcaat aatggttata gcctgttaga taatctaaat     7980

gcaattcccc tgttttgtcg tttaggagat aattatttat cttgcttttc atagtgttct     8040

taggaattat tttgttgtta cgttttggtg agttataccc attttattta tttagaaaaa     8100

tagtatcttt gttaacgact tacatggtca cagtatattt tgctgcaaga aataaagagg     8160

atatgataga aggttttttt tttttttttt tttttttttt gagacggagt cccactcttg     8220

tcgcccaact agagtgtagt ggcacaatct cggctcccca caacctctga ctccagggtt     8280

caggtgatta ttttgcctca gcctcccaag cagctgggat tatagacacc cgccaacacg     8340

ccaggctaat gtttttgtat ttttaataga gatggggttt tgccatgttg gccaggctgg     8400

tcttgaactc ctgacctcag gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac     8460

agacgtgagc caccactccc ggcccataga aggttttttg ctggataatt tgtaactttt     8520

ctaattggga aaaaattcct attaatcact taaaaatttt tttttgtatt ttgtgttatt     8580

gattatatac aaaggagact ttttttttga gataacactc aaatagtatt ctcttctttt     8640

gaaaatttta tttttatctg aaaataacag ttgatctgaa ataaaaaggg gagacctatt     8700

agaatgagag tagccaagga aagagttact aggtaataag cttcactttt tgtgttctaa     8760

ttgtttttga gatataaaga ccctgaaaaa gcccatttta gaacctgttt aataagagca     8820

aatatagggg aaaatctttg aaatgaaagc tacaaataca tgtgagaaga aaaaaatgga     8880

tttttttagc aaataattaa ctaagcttct aaatgcctag ctccctcccc caaaggcgct     8940

ttcccccgat ggaggcacag gcttctgtct cggatgtttg gcgcacgtga gtttgtatga     9000

gtttgtaccg gagtgacccc ggcagccact gcccacctcc cctctaccca ggggcctgaa     9060

aagaggggct gccctcctgc gccaaggcag acacaagctg cgggctgtgc ggtcctagta     9120

gtgtgacgtt tcagttaata gtggtggtct tattttcaac tatgctttca ttcagtcagt     9180

ctctgttgac taaatacgac gaaaattcat actttatgca ggagatttct aaaaatttaa     9240

tgtttattaa tagtttatga atatcaagat acctcattga atccctaaat ttaaaagcag     9300

tccagtaaaa ggttaactgt ataaagaatc tatgactttt tgagggaagt gtgatatatt     9360

aacaaatata accaattcta aatttgtttt agctctaacc tcatcaaacc aaaggcacag     9420

atttgtgtac aatataccca ttgaatgtat atcctgagaa aaattggggc caaagaagca     9480

ggaaaatctc aaagctctaa tggcagcata aatcaaagaa tttcacaggc tagtgttttt     9540

atccatagcc attgctccct tgtcaagtgt ctcacaagga catggaagaa tgtgttatgt     9600

tcatcttgta atcatagcaa aaagtctgca aaccccaggg tcaagcctgc tctgccacag     9660

ggttggatgg tgaccttggg caagtccctg gggctggcta ggcctccact tgtccatctg     9720

tgaaatgaaa ggatcagcct ggacagccct ctaaactccc ttacagctct cagcctaaga     9780

gcgcagcact gaacagcctc atcattccac ttttcatggg aaatatattt cacaccattg     9840

cctttgtgta gagaaatatt tcttttcctg tgttaatgag ctatgtactg aatataaacc     9900

agtgcattta aagtaatatc ttttgtgcac ctctaaatgt gtttggaatt gtgtttgttc     9960

tcatagaata tacaaaagta ctgattctag gtaagaagga gtctccacgg gtgtgccctg    10020

ctcagctgga tgtccatgag aacagccatg aaataagtca ctacttgtcc ccaaaaccac    10080

aggaatatat acctaggtca cctcaaattc ctgagtgtgc tctgccatgt tacacggtct    10140

tcaaattgaa aaggtttctt gaaaaggaaa gtttggccca gcaactggag aaggagtcca    10200

tggtgtcgct gtgtgcctgt atcatttggc caagtcaatg gttgtaagca aagttagtgg    10260

agacaaaaat gtgtccaaaa tgtcgtttga gttcctggga tttctgtaat agcacacaac    10320

tcagaactct tcagcatttg tgtgattcct tacctctggc tgataaaact ctaatgggtt    10380

gtggcttact ttgtttccat tttctttggc tttgtgcaat ttttgtgtaa ctttacttgt    10440

acctatattt tctgtttaca gttcttttta aggggagggg tagggttcta agatcttgtt    10500

gtttattgta gataaaaatt ttttcgtgtt gtagaaaagc atgggttatg cgtttgactg    10560

aaaaagacac tgtattattt accaaagggg tattgttttt gcatttgttt ataaatgcat    10620

tattttggta ctgtaaattt ggacataatt tctgagttta ttactactgg cattttcttt    10680

ttcccttttt ttttttttta accgtaagtg cacgatgcag gtgcataggc cccagaccaa    10740

actagaccac cagcatgttc atgtccagac ctcggcagtg gcgtgcactg cttgtgcacc    10800

tcagttcctc cagtgttggt ttgtttgttt tttaattcag catcctgctg gttttacttt    10860

ccaagcaaga tctgttgcga ctcccaaatg cgttttaatg agctcatcct tatttgcctt    10920

tcttcttacg tattttgtgt attagattgt gcaggagata ttctagaagg cattaatggt    10980

ttgcattcaa aacgatgtgg tttgtccaag ttattttctg tctttattac tgagacggat    11040

taatctcctt atttttttct tgatgatttg aagttgtaag agttgtccag ctattgctta    11100

ataaaatttt gcagatcaaa aaa                                            11123


<210> 1584
<211> 5988
<212> DNA
<213> Homo sapiens

<400> 1584
ggctctgtgt atgaatgaca aggatacctt cagccagctc attctggatg aatgaatgat       60

tacactaagt gtcctccaca ttcctctgtg ggctcacttc atggactcac tttgcgtgct      120

tgttaaatgt gctgtgttgc tcccaagacc atgtaaagcc tactgaccac taacctccct      180

cacagcagaa actagacgtc aggttaaaat gggcaactcc gacagtcagt acacccttca      240

aggatctaaa aatcatagca atactattac tggtgctaag caaattcctt gctccctgaa      300

aatacgtggc attcatgcaa aagaggaaaa gtcattgcat ggatggggtc acggaagcaa      360

cggagcaggt tacaagtcca ggtccctggc ccgaagctgc ctttctcact ttaagagtaa      420

ccagccttac gcatcgagac tcggtggccc cacatgcaag gtctccagag gtgttgccta      480

ctccacgcac aggacaaatg ccccagggaa ggatttccag ggcatcagtg ctgctttctc      540

aactgagaat ggcttccact ctgttggcca cgagctggca gataaccaca tcacctccag      600

agactgcaac ggacaccttc tcaactgcta cgggaggaat gagagcattg cctccacccc      660

accgggcgaa gaccgcaaga gcccccgagt gctcatcaaa acgctgggga agctggatgg      720

gtgtttaagg gtcgagttcc acaatggtgg caaccccagc aaagtgcctg cagaggactg      780

cagtgagccg gtgcagctgc tgaggtactc acctacctta gcatcggaaa cctcccctgt      840

gcctgaagcc aggagggggt ccagcgccga ttccctgccc agccatcgcc cctctcccac      900

ggactctcgc ctgcggtcca gcaaaggcag ctccctgagt tctgagtcat cctggtacga      960

ctccccttgg ggcaatgctg gagagctgag cgaggctgag ggctccttcc tggcccccgg     1020

catgcctgac cccagtctcc atgccagctt cccacctggc gatgccaaaa agcctttcaa     1080

ccaaagctct tccctctcct ccctccggga actgtacaaa gatgccaacc tggggagcct     1140

ctccccctca ggtatccgcc tttctgatga atacatgggc acgcatgcca gcctgagcaa     1200

ccgtgtctct tttgcttccg acattgatgt gccctccaga gtggcacacg gggaccccat     1260

ccagtacagt tccttcactc tcccctgtcg gaagcccaaa gcctttgttg aggatactgc     1320

gaagaaggac tccctcaaag ccaggatgcg acggatcagt gactggacgg gaagcctctc     1380

aaggaagaaa aggaaactcc aggagccgag gtccaaggag ggcagtgact actttgacag     1440

tcgctctgat ggactgaata cagatgtgca gggatcctcc caggcatctg cttttctgtg     1500

gtcagggggc tctactcaga tcctgtctca gagaagtgaa tccacacatg cgattggcag     1560

cgatcccctc cggcagaaca tttatgagaa tttcatgcga gagttggaaa tgagcaggac     1620

caacactgag aacatagaaa catctacaga aaccgccgag tccagcagcg agtcactcag     1680

ctctctggaa cagctggatc tgctctttga gaaggaacag ggggtggtcc ggaaggccgg     1740

gtggctcttc ttcaagcccc tggtcactgt gcagaaggaa aggaagcttg agctggtggc     1800

acgaaggaaa tggaaacagt actgggtaac gctgaaagga tgcacgctgc tgttttatga     1860

gacctatggg aagaattcca tggatcagag cagtgcccct cggtgtgctc tgtttgcaga     1920

agacagcata gtgcagtctg ttccagagca tcccaagaaa gaaaatgtgt tctgcctcag     1980

caactccttt ggagatgtct accttttcca ggccaccagc cagacagatc tagaaaactg     2040

ggtcactgct gtacactctg cttgtgcatc cctttttgca aagaagcatg ggaaagagga     2100

cacgctgcgg ctgctgaaga accagaccaa aaacctgctt cagaagatag acatggacag     2160

caagatgaag aagatggcag agctgcagct gtccgtggtg agcgacccaa agaacaggaa     2220

agccatagag aaccagatcc agcaatggga gcagaatctt gagaaatttc acatggatct     2280

gttcaggatg cgctgctatc tggccagcct acaaggtggg gagttaccga acccaaagag     2340

tctccttgca gccgccagcc gcccctccaa gctggccctc ggcaggctgg gcatcttgtc     2400

tgtttcctct ttccatgctc tggtatgttc tagagatgac tctgctctcc ggaaaaggac     2460

actgtcactg acccagcgag ggagaaacaa gaagggaata ttttcttcgt taaaagggct     2520

ggacacactg gccagaaaag gcaaggagaa gagaccttct ataactcaga tatttgattc     2580

aagtggcagc catggatttt ctggaactca gctacctcaa aactccagta actccagtga     2640

ggtcgatgaa cttctgcata tatatggttc aacagtagac ggtgttcccc gagacaatgc     2700

atgggaaatc cagacttatg tccactttca ggacaatcac ggagttactg tagggatcaa     2760

gccagagcac agagtagaag atattttgac tttggcatgc aagatgaggc agttggaacc     2820

cagccattat ggcctacagc ttcgaaaatt agtagatgac aatgttgagt attgcatccc     2880

tgcaccatat gaatatatgc aacaacaggt ttatgatgaa atagaagtct ttccactaaa     2940

tgtttatgac gtgcagctca cgaagactgg gagtgtgtgt gactttgggt ttgcagttac     3000

agcgcaggtg gatgagcgtc agcatctcag ccggatattt ataagcgacg ttcttcccga     3060

tggcctggcg tatggggaag ggctgagaaa gggcaatgag atcatgacct taaatgggga     3120

agctgtgtct gatcttgacc ttaagcagat ggaggccctg ttttctgaga agagcgtcgg     3180

actcactctg attgcccggc ctccggacac aaaagcaacc ctgtgtacat cctggtcaga     3240

cagtgacctg ttctccaggg accagaagag tctgctgccc cctcctaacc agtcccaact     3300

gctggaggaa ttcctggata actttaaaaa gaatacagcc aatgatttca gcaacgtccc     3360

tgatatcaca acaggtctga aaaggagtca gacagatggc actctggatc aggtttccca     3420

cagggagaaa atggagcaga cattcaggag tgctgagcag atcactgcac tgtgcaggag     3480

ttttaacgac agtcaggcca acggcatgga aggaccgcgg gagaatcagg atcctcctcc     3540

gaggtctctg gcccgccacc tgtctgatgc agaccgcctc cgcaaagtca tccaggagct     3600

tgtggacaca gagaagtcct acgtgaagga tttgagctgc ctctttgaat tatacttgga     3660

gccacttcag aatgagacct ttcttaccca agatgagatg gagtcacttt ttggaagttt     3720

gccagagatg cttgagtttc agaaggtgtt tctggagacc ctggaggatg ggatttcagc     3780

atcatctgac tttaacaccc tagaaacccc ctcacagttt agaaaattac tgttttccct     3840

tggaggctct ttcctttatt acgcggacca ctttaaactg tacagtggat tctgtgctaa     3900

ccatatcaaa gtacagaagg ttctggagcg agctaaaact gacaaagcct tcaaggcttt     3960

tctggacgcc cggaacccca ccaagcagca ttcctccacg ctggagtcct acctcatcaa     4020

gccggttcag agagtgctca agtacccgct gctgctcaag gagctggtgt ccctgacgga     4080

ccaggagagc gaggagcact accacctgac ggaagcacta aaggcaatgg agaaagtagc     4140

gagccacatc aatgagatgc agaagatcta tgaggattat gggaccgtgt ttgaccagct     4200

agtagctgag cagagcggaa cagagaagga ggtaacagaa ctttcgatgg gagagcttct     4260

gatgcactct acggtttcct ggttgaatcc atttctgtct ctaggaaaag ctagaaagga     4320

ccttgagctc acagtatttg tttttaagag agccgtcata ctggtttata aagaaaactg     4380

caaactgaaa aagaaattgc cctcgaattc ccggcctgca cacaactcta ctgacttgga     4440

cccatttaaa ttccgctggt tgatccccat ctccgcgctt caagtcagac tggggaatcc     4500

agcagggaca gaaaataatt ccatatggga actgatccat acgaagtcag aaatagaagg     4560

acggccagaa accatctttc agttgtgttg cagtgacagt gaaagcaaaa ccaacattgt     4620

taaggtgatt cgttctattc tgagggagaa cttcaggcgt cacataaagt gtgaattacc     4680

actggagaaa acgtgtaagg atcgcctggt acctcttaag aaccgagttc ctgtttcggc     4740

caaattagct tcatccaggt ctttaaaagt cctgaagaat tcctccagca acgagtggac     4800

cggtgagact ggcaagggaa ccttgctgga ctctgacgag ggcagcttga gcagcggcac     4860

ccagagcagc ggctgcccca cggctgaggg caggcaggac tccaagagca cttctcccgg     4920

gaaataccca caccccggct tggcagattt tgccgacaat ctcatcaaag agagtgacat     4980

cctgagcgat gaagatgatg accaccgtca gactgtgaag cagggcagcc ctactaaaga     5040

catcgaaatt cagttccaga gactgaggat ttccgaggac ccagacgttc accccgaggc     5100

tgagcagcag cctggcccgg agtcgggtga gggtcagaaa ggaggagagc agcccaaact     5160

ggtccggggg cacttctgcc ccattaaacg aaaagccaac agcaccaaga gggacagagg     5220

aactttgctc aaggcgcaga tccgtcacca gtcccttgac agtcagtctg aaaatgccac     5280

catcgaccta aattctgttc tagagcgaga attcagtgtc cagagtttaa catctgttgt     5340

cagtgaggag tgtttttatg aaacagagag ccacggaaaa tcatagtatg attcaatcca     5400

gatatgggtt aaattcctca ttttactttt aaactggtgg taaagtggaa attgcaaaaa     5460

aaaaaaaaaa aaaaaactgt tcattcctgg gttttgtgca gtatacattt tcccacaaaa     5520

tggttgtaaa gatttaagtt attttaattt attgtggatc agaaacctag atgaaactgg     5580

tcagaatctg taaattactt agtttatatc cactttgagc aggtatcaaa tgatttagga     5640

tccttaaaat tacattctaa taattaagtt atgtggaaaa agtaaggctg gggaagtcgt     5700

gattaatagt tttcaaaggg ccatttttta aaatcctctg ggcattttct ttcagctgtt     5760

tgttagtttt tgctttattt aaagcatatt taagttattt taatgtggtt taggggcaaa     5820

atgtgcagat acttcatttt tgtaagatag attgtaatag atgctgttta tactaaacat     5880

gtcataacta tctatacagt atatattaaa agaaagcttg tactgtatct tatttgatga     5940

tatttatttt ctctgccaag ctgtatagta aaaggaaaat aagtcaca                  5988


<210> 1585
<211> 3281
<212> DNA
<213> Homo sapiens

<400> 1585
gccagggcgg cacgggaggg cggcgcagga ggtgggacct gcgccgggaa ggctccggga       60

cgccagcgca cgcggagcgg ggaccccgga gagccagcag gcgagaagac cggccgaggg      120

agagccgatc gcgcctcgag agatccgagg aagtggtcgc gggccgggag gctcccgtgc      180

cgagccgagg ccaggggtct ggggtcgcag cccggcgtgc ctgcagctgc cgtcgctcgg      240

gagcagcagc tgtgcccggg atcccggcgg cggcggggga aggaggagct gcagctggac      300

tgtggcagct ggagggagag ggccgggctc ccctggcgga gccgcgctgg gacgactggc      360

tgaccgcggc catgcagtct tgacggagtc gctcgggcgc aggggagcag ccgcgggcgc      420

gccctcccgg gaaggggcac cggagcgcag gcagcagcac tttatctgcg actctccagc      480

ccagcgagag gcgaagcggt ttaccatgga acccgtgacc aagtggagcc ccaaacaagt      540

ggtggactgg actagagggt tggatgactg cctgcaacaa tatgtccaca agtttgaacg      600

agagaagatc aacggcgagc agctgctgca gatttcccat caggacctgg aggagctggg      660

ggtcacacgg attggacacc aggagcttgt gttggaggct gtggaccttc tctgtgcact      720

gaattatggc ctcgaaactg ataacatgaa gaacttggtt ctgaaactga gagcatcttc      780

ccacaattta cagaattaca taagtagccg acggaaaagt cccgcttacg atggcaacac      840

ctcccgcaag gcccccaatg agttcctgac ctcggtggtg gagctcatcg gcgccgccaa      900

ggccctgctg gcgtggctgg accgggctcc gtttacaggg atcactgatt tctcagtcac      960

gaagaacaaa attatccagc tttgcttgga cctgaccact acagtccaga aggattgctt     1020

tgtagcggaa atggaggata aagttttaac tgtggtcaag gttttaaatg gcatctgtga     1080

caaaacaatc cgatctacca cagatcctgt gatgagccag tgtgcatgtc tggaggaagt     1140

tcacttacca aacattaaac ctggggaagg cctgggcatg tacatcaaat caacctatga     1200

tgggttacac gtgattactg gaaccacaga aaatgtggga tggcagctga aaaatctggt     1260

gaagaaattg agagagaatc ccaccggagt tgtgttactg cttaagaagc gccccaccgg     1320

gtctttcaac tttactcctg ctcccctgaa aaacctacgg tggaagccac ctcttgtaca     1380

gacctcacct ccacccgcga caacccagtc ccctgaaagc actatggata cctcactgaa     1440

gaaggagaag tcagccatcc tggatcttta tattcctcct ccgcctgctg ttccctactc     1500

tccccgggat gagaatggca gttttgttta tggagggtcc agtaagtgca aacaaccatt     1560

gcctggtcct aagggttcag agtccccgaa ttccttcttg gaccaggaaa gccggagacg     1620

aagattcacc attgcagact cggatcagtt gcctgggtac tcggtggaaa ccaacattct     1680

gcccacaaaa atgagagaga aaacaccatc ttatggcaag ccacggcctt tgtccatgcc     1740

tgctgatggg aactggatgg ggattgtgga cccttttgcc agacctcgag gtcatggcag     1800

gaaaggggag gatgcccttt gccggtattt cagtaacgag cggattcctc cgatcattga     1860

agagagctcc tctcccccat accggttctc cagacccacg accgagcggc atctggtccg     1920

gggtgcggac tacatccgag gaagcaggtg ctacatcaac tcagatctcc acagcagcgc     1980

cacgattcca ttccaggagg aagggaccaa aaagaaatct ggctcctcag ctacgaagtc     2040

ctcgtccaca gaaccgtccc tcctggtcag ctggtttacg cgcctcaaac tgttgactca     2100

ctgagaggga ccctgctcag gccacctgcc tggctcctgc cccaagtgcc ttgcttttac     2160

agtggacagc ctcttctcgt ttcagcctca gtattatgta gggaccttat gcaatttctt     2220

tttcttttga aaagttatct actgcccttc ttggaagttt gcaggattgg atgggaacaa     2280

attcagagga tcttaggtgc tggcttgtgg agacaaaagg agggaaatgg gtagagcctg     2340

tttgtcttgc ttccccagag atagaatgtg aagacacgcg ctagaaatcg cagtcctggc     2400

cagagacgtt atggtcattg tgagggactg gtggcattgt tcctttttga ggggctgggg     2460

ggactcaaat tggtggctgt tttcacacag atgtgttggt ttgtggtcca acttctttat     2520

ctgaaaaagc cagtgagaaa acatttttga tttgattttt ctaaactatc taccatattt     2580

taagtgtagc agctttgact ttgcaataac gtggcaagta tctgatttct cctttgaggc     2640

agaggtttaa gtgtaggcct gttacacttg tttgatacct ttttcatgac agtctcagta     2700

tagatcagtt ggtacagaaa tacatgaaca cattttgata gggcttattt cacacaaaga     2760

agtttatggt tatttgtgtg gggtggtgtt gttatatatt attgtcttta agggaaaaga     2820

agctataaga ttcgctgaca gccaaagtat catttagaaa agtgaagcaa caagatttag     2880

gttgatgaaa gatacatgag tttgcatttt gacctgttca gtgtctgtct tccagcacgg     2940

tgtgtacact tcttcaaaat tgtacacagt ttgctaatta gaaatatctt ggaaagcctc     3000

atggtcacta attttcaact agcatcaggt attttgaaaa cgtgtgtctg gatattaact     3060

cttgtttaaa ctgaatgtat gatattttgt tagaatggaa aagtactatc ttgttaattt     3120

aagtatttta aatatagttg tatatttttc ttactcttag tcacctgtaa ttgaaatatt     3180

tctgttttgc gtcatacacg aagctagtga aaaagaaagt gcaaggcatt ttcagatgag     3240

caagtgacta tcgtggctgt tgccagcagg gcagtattgt t                         3281


<210> 1586
<211> 3268
<212> DNA
<213> Homo sapiens

<400> 1586
aactttgcaa cccgagcgcg cacgctctgc gctcggccct gccagggcgg cacgggaggg       60

cggcgcagga ggtgggacct gcgccgggaa ggctccggga cgccagcgca cgcggagcgg      120

ggaccccgga gagccagcag gcgagaagac cggccgaggg agagccgatc gcgcctcgag      180

agatccgagg aagtggtcgc gggccgggag gctcccgtgc cgagccgagg ccaggggtct      240

ggggtcgcag cccggcgtgc ctgcagctgc cgtcgctcgg gagcagcagc tgtgcccggg      300

atcccggcgg cggcggggga aggaggagct gcagctggac tgtggcagct ggagggagag      360

ggccgggctc ccctggcgga gccgcgctgg gacgactggc tgaccgcggc catgcagtct      420

tgacggagtc gctcgggcgc aggggagcag ccgcgggcgc gccctcccgg gaaggggcac      480

cggagcgcag gcagcagcac tttatctgcg actctccagc ccagcgagag gcgaagcggt      540

ttaccatgga acccgtgacc aagtggagcc ccaaacaagt ggtggactgg actagagggt      600

tggatgactg cctgcaacaa tatgtccaca agtttgaacg agagaagatc aacggcgagc      660

agctgctgca gatttcccat caggacctgg aggagctggg ggtcacacgg attggacacc      720

aggagcttgt gttggaggct gtggaccttc tctgtgcact gaattatggc ctcgaaactg      780

ataacatgaa gaacttggtt ctgaaactga gagcatcttc ccacaattta cagaattaca      840

taagtagccg acggaaaagt cccgcttacg atggcaacac ctcccgcaag gcccccaatg      900

agttcctgac ctcggtggtg gagctcatcg gcgccgccaa ggccctgctg gcgtggctgg      960

accgggctcc gtttacaggg atcactgatt tctcagtcac gaagaacaaa attatccagc     1020

tttgcttgga cctgaccact acagtccaga aggattgctt tgtagcggaa atggaggata     1080

aagttttaac tgtggtcaag gttttaaatg gcatctgtga caaaacaatc cgatctacca     1140

cagatcctgt gatgagccag tgtgcatgtc tggaggaagt tcacttacca aacattaaac     1200

ctggggaagg cctgggcatg tacatcaaat caacctatga tgggttacac gtgattactg     1260

gaaccacaga aaattctcct gcagacagat ctcagaagat tcatgctggt gacgaagtca     1320

ttcaagttaa tcagcaaact gtggtgggat ggcagctgaa aaatctggtg aagaaattga     1380

gagagaatcc caccggagtt gtgttactgc ttaagaagcg ccccaccggg tctttcaact     1440

ttactcctgc tcccctgaaa aacctacggt ggaagccacc tcttgtacag acctcacctc     1500

cacccgcgac aacccagtcc cctgaaagca ctatggatac ctcactgaag aaggagaagt     1560

cagccatcct ggatctttat attcctcctc cgcctgctgt tccctactct ccccgggatg     1620

agaatggcag ttttgtttat ggagggtcca gtaagtgcaa acaaccattg cctggtccta     1680

agggttcaga gtccccgaat tccttcttgg accaggaaag ccggagacga agattcacca     1740

ttgcagactc ggatcagttg cctgggtact cggtggaaac caacattctg cccacaaaaa     1800

tgagagagaa aacaccatct tatggcaagc cacggccttt gtccatgcct gctgatggga     1860

actggatggg gattgtggac ccttttgcca gacctcgagg tcatggcagg aaaggggagg     1920

atgccctttg ccggtatttc agtaacgagc ggattcctcc gatcattgaa gagagctcct     1980

ctcccccata ccggttctcc agacccacga ccgagcggca tctggtccgg ggtgcggact     2040

acatccgagg aagcaggtgc tacatcaact cagatctcca cagcagcgcc acgattccat     2100

tccaggagga agggaccaaa aagaaatctg gctcctcagc tacgaagtcc tcgtccacag     2160

aaccgtccct cctggtcagc tggtttacgc gcctcaaact gttgactcac tgagagggac     2220

cctgctcagg ccacctgcct ggctcctgcc ccaagtgcct tgcttttaca gtggacagcc     2280

tcttctcgtt tcagcctcag tattatgtag ggaccttatg caatttcttt ttcttttgaa     2340

aagttatcta ctgcccttct tggaagtttg caggattgga tgggaacaaa ttcagaggat     2400

cttaggtgct ggcttgtgga gacaaaagga gggaaatggg tagagcctgt ttgtcttgct     2460

tccccagaga tagaatgtga agacacgcgc tagaaatcgc agtcctggcc agagacgtta     2520

tggtcattgt gagggactgg tggcattgtt cctttttgag gggctggggg gactcaaatt     2580

ggtggctgtt ttcacacaga tgtgttggtt tgtggtccaa cttctttatc tgaaaaagcc     2640

agtgagaaaa catttttgat ttgatttttc taaactatct accatatttt aagtgtagca     2700

gctttgactt tgcaataacg tggcaagtat ctgatttctc ctttgaggca gaggtttaag     2760

tgtaggcctg ttacacttgt ttgatacctt tttcatgaca gtctcagtat agatcagttg     2820

gtacagaaat acatgaacac attttgatag ggcttatttc acacaaagaa gtttatggtt     2880

atttgtgtgg ggtggtgttg ttatatatta ttgtctttaa gggaaaagaa gctataagat     2940

tcgctgacag ccaaagtatc atttagaaaa gtgaagcaac aagatttagg ttgatgaaag     3000

atacatgagt ttgcattttg acctgttcag tgtctgtctt ccagcacggt gtgtacactt     3060

cttcaaaatt gtacacagtt tgctaattag aaatatcttg gaaagcctca tggtcactaa     3120

ttttcaacta gcatcaggta ttttgaaaac gtgtgtctgg atattaactc ttgtttaaac     3180

tgaatgtatg atattttgtt agaatggaaa agtactatct tgttaattta agtattttaa     3240

atatagttgt atatttttct tactctta                                        3268


<210> 1587
<211> 3431
<212> DNA
<213> Homo sapiens

<400> 1587
atgcggtccc gggttctgtg gggcgctgcc cggtggctct ggccccgccg ggccgttggc       60

ccagcccgcc ggcccctgag ctccggtagc ccgccgctgg aggagctgtt cacccggggc      120

gggcccttgc ggaccttcct cgagcgccag gcggggtctg aagcccattt gaaggtcagg      180

aggcccgagt tgctggcggt gatcaaactg ctgaacgaga aggagcggga gctgcgggag      240

actgagcact tgctgcacga tgagaatgaa gatttaagga aacttgcaga gaatgaaatc      300

actttgtgtc aaaaagaaat aactcagctg aagcatcaga ttatcttact tttggttccc      360

tcagaagaaa cagatgaaaa tgatttgatc ctggaagtaa ctgcaggagt tggaggtggc      420

cttagacatg catctgccag cattgggggt tcagaagcct ataggcacat gaaatttgaa      480

ggaggtgttc acagagtaca aagagtgcca aagacagaaa agcaaggccg cgtccatact      540

agcaccatga ctgtagcaat attaccccag cctactgaga ttaatctggt gattaatccg      600

aaagatttga gaattgacac taagcgagcc agtggagctg gggggcagca tgtaaatacc      660

acggacagtg ctgtccggat agttcatctt ccaacagatt ggaagtaaag gaagatcaga      720

gaaaataaga acatataatt ttccacagaa ccgggtcaca gatcacagaa taaacaagac      780

gctgcatgat cttgaaactt ttatgcaagg agattatcta ctggatgaac ttgtacagtc      840

attgaaggaa tacgccgatt atgaatcttt agtagaaatt atttcccaaa aagtttaagt      900

tgatttgtta tttatagact ttcgtatctt agaaaaattc tacagtacat ccacataggg      960

tgaaagtacc cttactctct tgaaaaacgt tgagttaaca cagttggagg taatatgcat     1020

attctgaagt catagataat ttacacagat ctctctcaat gcattagcaa aaatcataca     1080

atatacagat ggtcctcgat ttacattgtg gttaattccc aataaaccca tcataagtta     1140

aaaatgcata taacgttagc aacacagcag tctcctaatt aatgacagct tgacttaaca     1200

attttccaac tttaccatgg tgtgaaagag gtatgattcc taagccctaa ggagctcctc     1260

agcttgaaat ggggctgcat ccctataaac ccatcataaa gtcaaaaaat cctaaaacat     1320

aagttggtga ccatctgtaa tcatgatgtg gtggtaaatc ttggacgcta ccttacaata     1380

actagacaaa ggaaaatcat cctttgtcct gttctgtgta aatatttaat gaatgatcaa     1440

aacttcagtt taaatattat gaaaaacttt aaacataaag tagtagaaat aagacagtaa     1500

atactgtatc ctaatatcca gtcaggatac agaaaccata ccattaactt gaacagggat     1560

aattttaata taaaaactgt taactgataa tggtattaac ttttaagagg gatgaaagag     1620

agctatgatg tcctaggact gagagtaccc caggaaagaa tacccttgaa agggtctccc     1680

cttccccatg gtgaagtcag gcctaatgga gagagtggct acagcctact cagtgattgg     1740

gaaattccct gtcttgccct gggccagagc tggtgtaccg ctggtggatc aggtcttaca     1800

agcaaagaac ctcacactcc caactggtaa gccagaagcc tcttgctagg gtgtgagcaa     1860

aacttggaca ggaactctca gtagatgttt gtgtttgtca agattctcca gacaaacttc     1920

cttaaaagga ttggcttgtg ttgttattat taagtctaac aagtccaaaa gctggagtgt     1980

gaggcaggag gctggaaacc caggaaagct gatggtgcaa ggtccagtcc aaaggtatct     2040

gttggaggat tctcttgttc tgggaagagg acggtctttt tttctcttca gaccttcacc     2100

tgactggatc aagcccacta acatcgagga ggacagtctg cattactcag agttcactga     2160

ttgatttaaa tgtcaatctc atataaaaca ccctcacaga aacacctaga ataatgtttg     2220

accttataat tggaaaatca gagcaaaagt taaatctcaa aaaaaaaaaa aaaaaaagta     2280

tgacccagta gctaggcacc tgtggccccg ccaagttgac acataaaatt aactgtcaca     2340

gtatcatctt agaagtgaaa gaagcccctt tatcctgcag tgcccctcta ccaccaccta     2400

ctgacaaaga acatggtgct atctggcatg ggagaaatgt tcagtttgct atggcttgta     2460

tgtgtcccct caaattcaag tgttgccaat gtgacagcat caagaggtgg ggtctttaag     2520

agatcactag gccatgaggg attctcttag gactgggatg aaggcccata ataaaagagg     2580

tttcggggag catcctgcta gcttgccttc tgtatgtgag aacacagcaa gaaagcccta     2640

gtcaacaagt gccagctcct tgatcttaga cttcccatcc tccagaactg tgagaaatac     2700

atttctgttc cttacaaatt acccagtctc ctgtattctg ttatagcagc acaaaatgaa     2760

gataccatac ctgaacacct gaacattctt cacaaggtag taaatgcact gctttattct     2820

ggtctcagta ttgtgtgctt aataaggaaa tgagaaaggg tggatcaggg cataggatga     2880

acaagttact gctagacctc tcacaatgcc actaatggat aagattgtat tttcatcatt     2940

cttgtctctt cggaagctaa caccatgcta taataggcac taaatagatg tctaaaaaca     3000

ccttaagtat ttgtctagaa atctggtgca ttgttcagaa agaaccaaaa ttcaaaataa     3060

tttcaaaggg cctaaagcac tagttaatca aaattcatta gtttttaatg gtactaccac     3120

tctcaaattt aaaatgtcat cttacgttcc tcttcctcgc attggattta ttgctaaaac     3180

ctggtaaaca cttttaatcc ttttcaattc cattaccact gctcttgtcc agaattactt     3240

cgcagactaa tagtcacctg acttctcccc tgcatccgat ttgctgtcta attctggtta     3300

caaataagta actgccaaac taatctttct aaaaagcaag actgatctcg tcactccttt     3360

gctcaacaat gtaaaagctc ccattgtctc ccaaataaaa ccagctttcc actgtgtata     3420

caatacatcc a                                                          3431


<210> 1588
<211> 3539
<212> DNA
<213> Homo sapiens

<400> 1588
atgcggtccc gggttctgtg gggcgctgcc cggtggctct ggccccgccg ggccgttggc       60

ccagcccgcc ggcccctgag ctccggtagc ccgccgctgg aggagctgtt cacccggggc      120

gggcccttgc ggaccttcct cgagcgccag gcggggtctg aagcccattt gaaggtcagg      180

aggcccgagt tgctggcggt gatcaaactg ctgaacgaga aggagcggga gctgcgggag      240

actgagcact tgctgcacga tgagaatgaa gatttaagga aacttgcaga gaatgaaatc      300

actttgtgtc aaaaagaaat aactcagctg aagcatcaga ttatcttact tttggttccc      360

tcagaagaaa cagatgaaaa tgatttgatc ctggaagtaa ctgcaggagt tggaggtcag      420

gaggcaatgt tgtttacatc agagatattt gatatgtatc agcaatatgc tgcatttaaa      480

agatggcatt ttgaaaccct ggaatatttt ccaagtgaac taggtggcct tagacatgca      540

tctgccagca ttgggggttc agaagcctat aggcacatga aatttgaagg aggtgttcac      600

agagtacaaa gagtgccaaa gacagaaaag caaggccgcg tccatactag caccatgact      660

gtagcaatat taccccagcc tactgagatt aatctggtga ttaatccgaa agatttgaga      720

attgacacta agcgagccag tggagctggg gggcagcatg taaataccac ggacagtgct      780

gtccggatag ttcatcttcc aacagattgg aagtaaagga agatcagaga aaataagaac      840

atataatttt ccacagaacc gggtcacaga tcacagaata aacaagacgc tgcatgatct      900

tgaaactttt atgcaaggag attatctact ggatgaactt gtacagtcat tgaaggaata      960

cgccgattat gaatctttag tagaaattat ttcccaaaaa gtttaagttg atttgttatt     1020

tatagacttt cgtatcttag aaaaattcta cagtacatcc acatagggtg aaagtaccct     1080

tactctcttg aaaaacgttg agttaacaca gttggaggta atatgcatat tctgaagtca     1140

tagataattt acacagatct ctctcaatgc attagcaaaa atcatacaat atacagatgg     1200

tcctcgattt acattgtggt taattcccaa taaacccatc ataagttaaa aatgcatata     1260

acgttagcaa cacagcagtc tcctaattaa tgacagcttg acttaacaat tttccaactt     1320

taccatggtg tgaaagaggt atgattccta agccctaagg agctcctcag cttgaaatgg     1380

ggctgcatcc ctataaaccc atcataaagt caaaaaatcc taaaacataa gttggtgacc     1440

atctgtaatc atgatgtggt ggtaaatctt ggacgctacc ttacaataac tagacaaagg     1500

aaaatcatcc tttgtcctgt tctgtgtaaa tatttaatga atgatcaaaa cttcagttta     1560

aatattatga aaaactttaa acataaagta gtagaaataa gacagtaaat actgtatcct     1620

aatatccagt caggatacag aaaccatacc attaacttga acagggataa ttttaatata     1680

aaaactgtta actgataatg gtattaactt ttaagaggga tgaaagagag ctatgatgtc     1740

ctaggactga gagtacccca ggaaagaata cccttgaaag ggtctcccct tccccatggt     1800

gaagtcaggc ctaatggaga gagtggctac agcctactca gtgattggga aattccctgt     1860

cttgccctgg gccagagctg gtgtaccgct ggtggatcag gtcttacaag caaagaacct     1920

cacactccca actggtaagc cagaagcctc ttgctagggt gtgagcaaaa cttggacagg     1980

aactctcagt agatgtttgt gtttgtcaag attctccaga caaacttcct taaaaggatt     2040

ggcttgtgtt gttattatta agtctaacaa gtccaaaagc tggagtgtga ggcaggaggc     2100

tggaaaccca ggaaagctga tggtgcaagg tccagtccaa aggtatctgt tggaggattc     2160

tcttgttctg ggaagaggac ggtctttttt tctcttcaga ccttcacctg actggatcaa     2220

gcccactaac atcgaggagg acagtctgca ttactcagag ttcactgatt gatttaaatg     2280

tcaatctcat ataaaacacc ctcacagaaa cacctagaat aatgtttgac cttataattg     2340

gaaaatcaga gcaaaagtta aatctcaaaa aaaaaaaaaa aaaaagtatg acccagtagc     2400

taggcacctg tggccccgcc aagttgacac ataaaattaa ctgtcacagt atcatcttag     2460

aagtgaaaga agccccttta tcctgcagtg cccctctacc accacctact gacaaagaac     2520

atggtgctat ctggcatggg agaaatgttc agtttgctat ggcttgtatg tgtcccctca     2580

aattcaagtg ttgccaatgt gacagcatca agaggtgggg tctttaagag atcactaggc     2640

catgagggat tctcttagga ctgggatgaa ggcccataat aaaagaggtt tcggggagca     2700

tcctgctagc ttgccttctg tatgtgagaa cacagcaaga aagccctagt caacaagtgc     2760

cagctccttg atcttagact tcccatcctc cagaactgtg agaaatacat ttctgttcct     2820

tacaaattac ccagtctcct gtattctgtt atagcagcac aaaatgaaga taccatacct     2880

gaacacctga acattcttca caaggtagta aatgcactgc tttattctgg tctcagtatt     2940

gtgtgcttaa taaggaaatg agaaagggtg gatcagggca taggatgaac aagttactgc     3000

tagacctctc acaatgccac taatggataa gattgtattt tcatcattct tgtctcttcg     3060

gaagctaaca ccatgctata ataggcacta aatagatgtc taaaaacacc ttaagtattt     3120

gtctagaaat ctggtgcatt gttcagaaag aaccaaaatt caaaataatt tcaaagggcc     3180

taaagcacta gttaatcaaa attcattagt ttttaatggt actaccactc tcaaatttaa     3240

aatgtcatct tacgttcctc ttcctcgcat tggatttatt gctaaaacct ggtaaacact     3300

tttaatcctt ttcaattcca ttaccactgc tcttgtccag aattacttcg cagactaata     3360

gtcacctgac ttctcccctg catccgattt gctgtctaat tctggttaca aataagtaac     3420

tgccaaacta atctttctaa aaagcaagac tgatctcgtc actcctttgc tcaacaatgt     3480

aaaagctccc attgtctccc aaataaaacc agctttccac tgtgtataca atacatcca      3539


<210> 1589
<211> 3676
<212> DNA
<213> Homo sapiens

<400> 1589
atgcggtccc gggttctgtg gggcgctgcc cggtggctct ggccccgccg ggccgttggc       60

ccagcccgcc ggcccctgag ctccggtagc ccgccgctgg aggagctgtt cacccggggc      120

gggcccttgc ggaccttcct cgagcgccag gcggggtctg aagcccattt gaaggtcagg      180

aggcccgagt tgctggcggt gatcaaactg ctgaacgaga aggagcggga gctgcgggag      240

actgagcact tgctgcacga tgagaatgaa gatttaagga aacttgcaga gaatgaaatc      300

actttgtgtc aaaaagaaat aactcagctg aagcatcaga ttatcttact tttggttccc      360

tcagaagaaa cagatgaaaa tgatttgatc ctggaagtaa ctgcaggagt tggaggtcag      420

gaggcaatgt tgtttacatc agagatattt gatatgtatc agcaatatgc tgcatttaaa      480

agatggcatt ttgaaaccct ggaatatttt ccaagtgaac taggtggcct tagacatgca      540

tctgccagca ttgggggttc agaagcctat aggcacatga aatttgaagg aggtgttcac      600

agagtacaaa gagtgccaaa gacagaaaag caaggccgcg tccatactag caccatgact      660

gtagcaatat taccccagcc tactgagatt aatctggtga ttaatccgaa agatttgaga      720

attgacacta agcgagccag tggagctggg gggcagcatg taaataccac ggacagtgct      780

gtccggatag ttcatcttcc aacaggtgtt gtttctgaat gtcaacaaga gagatctcag      840

ctgaaaaata aagagctggc tatgacaaag ttacgtgcaa aactgtacag catgcatcta      900

gaagaagaaa taaataaaag acagaatgct agaaaaattc agattggaag taaaggaaga      960

tcagagaaaa taagaacata taattttcca cagaaccggg tcacagatca cagaataaac     1020

aagacgctgc atgatcttga aacttttatg caaggagatt atctactgga tgaacttgta     1080

cagtcattga aggaatacgc cgattatgaa tctttagtag aaattatttc ccaaaaagtt     1140

taagttgatt tgttatttat agactttcgt atcttagaaa aattctacag tacatccaca     1200

tagggtgaaa gtacccttac tctcttgaaa aacgttgagt taacacagtt ggaggtaata     1260

tgcatattct gaagtcatag ataatttaca cagatctctc tcaatgcatt agcaaaaatc     1320

atacaatata cagatggtcc tcgatttaca ttgtggttaa ttcccaataa acccatcata     1380

agttaaaaat gcatataacg ttagcaacac agcagtctcc taattaatga cagcttgact     1440

taacaatttt ccaactttac catggtgtga aagaggtatg attcctaagc cctaaggagc     1500

tcctcagctt gaaatggggc tgcatcccta taaacccatc ataaagtcaa aaaatcctaa     1560

aacataagtt ggtgaccatc tgtaatcatg atgtggtggt aaatcttgga cgctacctta     1620

caataactag acaaaggaaa atcatccttt gtcctgttct gtgtaaatat ttaatgaatg     1680

atcaaaactt cagtttaaat attatgaaaa actttaaaca taaagtagta gaaataagac     1740

agtaaatact gtatcctaat atccagtcag gatacagaaa ccataccatt aacttgaaca     1800

gggataattt taatataaaa actgttaact gataatggta ttaactttta agagggatga     1860

aagagagcta tgatgtccta ggactgagag taccccagga aagaataccc ttgaaagggt     1920

ctccccttcc ccatggtgaa gtcaggccta atggagagag tggctacagc ctactcagtg     1980

attgggaaat tccctgtctt gccctgggcc agagctggtg taccgctggt ggatcaggtc     2040

ttacaagcaa agaacctcac actcccaact ggtaagccag aagcctcttg ctagggtgtg     2100

agcaaaactt ggacaggaac tctcagtaga tgtttgtgtt tgtcaagatt ctccagacaa     2160

acttccttaa aaggattggc ttgtgttgtt attattaagt ctaacaagtc caaaagctgg     2220

agtgtgaggc aggaggctgg aaacccagga aagctgatgg tgcaaggtcc agtccaaagg     2280

tatctgttgg aggattctct tgttctggga agaggacggt ctttttttct cttcagacct     2340

tcacctgact ggatcaagcc cactaacatc gaggaggaca gtctgcatta ctcagagttc     2400

actgattgat ttaaatgtca atctcatata aaacaccctc acagaaacac ctagaataat     2460

gtttgacctt ataattggaa aatcagagca aaagttaaat ctcaaaaaaa aaaaaaaaaa     2520

aagtatgacc cagtagctag gcacctgtgg ccccgccaag ttgacacata aaattaactg     2580

tcacagtatc atcttagaag tgaaagaagc ccctttatcc tgcagtgccc ctctaccacc     2640

acctactgac aaagaacatg gtgctatctg gcatgggaga aatgttcagt ttgctatggc     2700

ttgtatgtgt cccctcaaat tcaagtgttg ccaatgtgac agcatcaaga ggtggggtct     2760

ttaagagatc actaggccat gagggattct cttaggactg ggatgaaggc ccataataaa     2820

agaggtttcg gggagcatcc tgctagcttg ccttctgtat gtgagaacac agcaagaaag     2880

ccctagtcaa caagtgccag ctccttgatc ttagacttcc catcctccag aactgtgaga     2940

aatacatttc tgttccttac aaattaccca gtctcctgta ttctgttata gcagcacaaa     3000

atgaagatac catacctgaa cacctgaaca ttcttcacaa ggtagtaaat gcactgcttt     3060

attctggtct cagtattgtg tgcttaataa ggaaatgaga aagggtggat cagggcatag     3120

gatgaacaag ttactgctag acctctcaca atgccactaa tggataagat tgtattttca     3180

tcattcttgt ctcttcggaa gctaacacca tgctataata ggcactaaat agatgtctaa     3240

aaacacctta agtatttgtc tagaaatctg gtgcattgtt cagaaagaac caaaattcaa     3300

aataatttca aagggcctaa agcactagtt aatcaaaatt cattagtttt taatggtact     3360

accactctca aatttaaaat gtcatcttac gttcctcttc ctcgcattgg atttattgct     3420

aaaacctggt aaacactttt aatccttttc aattccatta ccactgctct tgtccagaat     3480

tacttcgcag actaatagtc acctgacttc tcccctgcat ccgatttgct gtctaattct     3540

ggttacaaat aagtaactgc caaactaatc tttctaaaaa gcaagactga tctcgtcact     3600

cctttgctca acaatgtaaa agctcccatt gtctcccaaa taaaaccagc tttccactgt     3660

gtatacaata catcca                                                     3676


<210> 1590
<211> 6434
<212> DNA
<213> Homo sapiens

<400> 1590
cgcgcttggg cggcggaggc tgcagctacc tcggcgccgg ctcggctcta ggacgtgtcg       60

ggctgcacgg gtcgggggcg gctccctgct gcttccgagc ctagccgcct ggccttcggc      120

atttgcagac acactgccct ccagaaacga tgggtgtcgc tagatccagc tgggactctg      180

ccagcctccg gcactcagtc taagagaagg gccatcttcc agccctgctg tccctgcctg      240

tcatggccac attcggctgc tgtctgcatg tctggggaca cagggcaccc agccccagcc      300

ctgagaagtt aagccaggcc ttctggctca gttccacagg ggcactccag accccaggcc      360

cctttcagag caaaagcaac tgatgctatg ggagaagccc ctgcccacct gtccactcgc      420

ctggcactgc ccactctgag acccatgcac tgggttcccc tggaggtgcc aaccctgtga      480

gtccctccct gtcccctgac gctgagaagg ccctgccaac ccccaccatg tgtgaggtga      540

tgcccacaat caatgagggg gaccgcctgg gtccccctca tggcgccgat gctgacgcca      600

acttcgagca gctgatggtg aacatgctgg acgagcggga gaagttgctg gagtctcttc      660

gggagagtca ggagaccttg gcggccacac agagccggct ccaggatgcc atacacgagc      720

gggaccagct ccagcgccac cttaactccg ccctccccca ggaatttgcc accttaaccc      780

gggagctgag catgtgtcgg gagcagcttc tagagcggga ggaagagata tcagaactga      840

aagcagaacg gaataacaca cggctgcttc tggaacatct ggagtgcctg gtgtcccgcc      900

atgaacggtc actgcggatg actgtggtga agcgccaggc ccagtcacct tcgggggtct      960

ccagtgaggt ggaggtgctg aaggccctca agtcactgtt tgagcaccac aaggccctgg     1020

atgagaaggt gcgagagcgg ctccgggcag cgctggagcg agtcaccacc ttggaggagc     1080

agctggcagg tgcccaccag caggtgtctg ccctgcagca gggggcaggg gtgcgggatg     1140

gagcggcaga agaggagggg actgtggagc tggggccgaa acgcctgtgg aaggaggata     1200

cgggccgggt agaggagctg caggagctcc tggagaagca gaactttgag ttgagccagg     1260

cccgggagcg actggtcacc ctaacaacaa ccgtgactga actcgaggag gacctgggca     1320

cggcccgccg ggacctcatc aagtcggagg agctgagcag caagcatcag cgggacctcc     1380

gggaggctct ggcccagaag gaggacatgg aagagcggat tactacactg gagaagcgct     1440

acctggctgc tcagcgtgag gcaacatcca tccatgacct caatgacaag ctggagaatg     1500

agctggccaa caaggagtcc ctgcaccgcc agtgtgagga gaaggcccga cacctgcagg     1560

agctgctgga ggtggcagag cagaagctgc agcagacgat gcgcaaggca gagacgctgc     1620

cagaggtgga ggctgagctg gcccagagaa ttgcagccct caccaaggct gaagaacggc     1680

atggcaacat tgaggagcac ctgcggcagc tggagggaca gctggaggag aagaaccagg     1740

agctggcacg ggtgcgccag cgggaaaaga tgaatgagga ccacaacaag cggctgtcgg     1800

acacagtgga ccggctgctc agcgagtcca acgagcgtct gcagctccac ctgaaggagc     1860

gcatggctgc cctggaggag aagggccgcc tgtctgaaga gattgagaag ctgcgccaag     1920

aggtggacca gctgaagggc cgaggggggc cgtttgtgga tggcgtccac tccaggtcgc     1980

acatgggcag tgcagcagac gtgcggttct ccctgggcac aaccacacac gcacccccag     2040

gcgtgcatcg ccgctactcg gcattgaggg aagagtctgc caaggactgg gagacttctc     2100

cactgcctgg gatgctggcc ccggcagctg gccctgcctt tgacagtgac cctgagatct     2160

ccgacgtgga tgaggatgag ccagggggtc tggtgggctc tgcggatgtt gtctccccca     2220

gcggccactc agatgcccag accctggcca tgatgctgca ggagcagctg gatgccatca     2280

atgaggaaat caggatgatt caggaagaga aggagtccac ggagctccgc gcggaggaga     2340

ttgagacgcg tgtaaccagt ggcagcatgg aagccctaaa cctgaagcag ctgcgcaagc     2400

gtggttccat ccccacctct ctgacggccc tgtccctggc cagcgcgtcc ccaccactca     2460

gcggccgctc cacacctaag ctcacctccc gcagtgctgc ccaggacctg gaccgaatgg     2520

gggtcatgac cctgcccagt gacttaagaa agcataggag gaagctgctg tcgccagtgt     2580

ctcgggaaga gaaccgagag gataaagcca ccataaaatg tgagacttct cctccttcct     2640

cacccaggac gctgcggcta gagaagcttg gccacccagc cctgagccag gaagaaggca     2700

agagtgcctt ggaggatcag ggcagcaacc ccagcagcag caacagcagc caggactccc     2760

tgcacaaggg cgccaagcgc aagggcatca agtcgtccat tggccgcctg tttgggaaga     2820

aggagaaggg caggctgatc cagctgagtc gggatggagc cacaggccat gttctgctaa     2880

cagactccga attcagtatg caggagccta tggtgcctgc caagctgggg acccaggcag     2940

agaaggaccg gcggctaaag aagaaacacc agctgcttga agatgcccgc aggaaaggaa     3000

tgccctttgc ccagtgggat ggtcctactg tggtctcctg gttggagctc tgggtgggga     3060

tgcctgcctg gtatgtggca gcctgccggg ccaacgtcaa gagtggtgcc atcatgtccg     3120

ctctgtcgga cacagagatc cagcgggaga tcggcatcag caatgccctg caccggctca     3180

agctccgcct ggccattcag gagatggtgt cattgaccag cccctctgcc ccacccacct     3240

ccaggacttc ttctgggaat gtctgggtca cccatgaaga gatggaaact ctggaaacat     3300

ctactaaaac agacagtgag gagggcagct gggctcagac cctggcctat ggggacatga     3360

accatgagtg gattgggaat gaatggctac ccagcctggg gctcccgcag taccgcagct     3420

acttcatgga gtgcctggtg gacgcccgca tgctggacca cctcaccaag aaggacctgc     3480

gggtccacct gaagatggtg gacagcttcc atcgaaccag tcttcagtat ggcatcatgt     3540

gtctgaagag gctgaattat gaccggaagg agctggagaa gaggcgagag gagagccagc     3600

atgagatcaa ggatgtgtta gtctggacca acgaccaggt ggttcattgg gtccagtcta     3660

ttgggctccg ggactacgca ggaaacctgc atgagagtgg tgtgcatgga gccttgctgg     3720

ccctggacga gaacttcgac cacaacacac tggccctgat cctccagatc cccacacaga     3780

acacccaggc acgccaagtg atggaaagag agttcaataa cctgttggcc ttgggcacag     3840

accggaagct ggatgacggg gatgacaagg tgtttcgccg cgcgccctcc tggaggaagc     3900

gcttccggcc gcgggagcac cacggtcgcg gcggcatgct cagcgcttcc gcggagaccc     3960

tcccggcggg cttccgtgtg tccaccctgg ggaccctgca gcccccaccg gccccgccaa     4020

agaagatcat gcctgaagct cactcccact atctctacgg acacatgctc tccgccttcc     4080

gggactagcc atggccccca gggctggctt cctccttctg ggtttcacag gctcctctgg     4140

ccctgacccc tcttgctcgt tccccttcct tccgcagctc ctagtctcgt ccgtgacttt     4200

ccggttgccc tggatctcag aatatattcg tccaccccct cggcacccca ttaccccgag     4260

tcccaccgtg tgtccgttgt aagtccggtg gatgtggctg gggtttcctg gtattgtgga     4320

ggcacccagg ttgtccatgc ttgggattct gggggaagga gagaagggca gctcagggtg     4380

gatgtgaagc cacccttcct cttctggacc cagcctggtc tgcactgcaa cctccaccag     4440

gaccaggatc ctgggccaca ggctgggatg gtccttccaa gaaagggtca tttcagacgc     4500

agccctgctt gggctattca atcttagggt gtctatccac gtctggctgt gccaaatggt     4560

ctggcagctg gttttggcat ccccagcatc accactctcc caacccatca ccgtgactgc     4620

agttcctgcc cccattctct tggggtcagg gaggggctgg gaagggctac tgaaggcccc     4680

attctcccac aggatggtga ggctgggagg aggaagactg aggtagagat tccaggccct     4740

ggcataagct gaatcccaaa tttgagtttg ggaagaacca gagagaaatg gatccctgag     4800

ctctgagcca agggtgagga tggggaaact ctaagctccc acctaataag aagcataggc     4860

agaccagcca gagggagagc caatggcctc tggtagcctt aagcccaaag ggcagtggga     4920

atgtcccctg ccccaaccat cgggtggagc tcctgctggg ctatggggaa gggaggttgt     4980

gcggatcttg actctagggc agaacagatc taaccatgca ttgctagctc tgctcccagc     5040

atcccttccc cttctctcct cctctgcctc acttctttag taatcccaac cctataaaaa     5100

tgaacctaat gggtggattg aatatacatt gagcccaaag tcaagtttgg ggaaaaggca     5160

gactaaggcc tcctttctct gacctcccag gaagaaaata gcttctccta cagtgattca     5220

tgtcccaggt ccaggaaatc caatgttggt gaaggcagcc actctcttgc ttgtccccaa     5280

atcacctaac cctcatccag ggctattttg gtgggcaggg actgcctcct cccggaattc     5340

ctaagatccg cccagctgcc accattttca ttgctttccc cagcagcatg atgggaaccc     5400

aagctgaggg atacaggtcc tgatttggta ggaatattat tcccaagaaa tacccgctcc     5460

tcacctactc cctcatccta ccaaggtgcc tgaaaatgtt caagacttat gttcagggtg     5520

ggatgatgga accgagggct tcatcaaagt gagaggaaag gaaaagcatc tggcatgtgt     5580

ttcttggata ggggccagtg cagtgccatc ctacaggtgg ctggagcagc tgctttgcaa     5640

cctgatcacc ttgagttctg agcagggact aggcttgcag gtgagataat gggccagggc     5700

acccagtcca gaaggagcaa tggcacctgg gcagtgccag ggcttaaagc ccgctgctcc     5760

ttttcggtag aggagaggcc catcactggt gtggtggggt gggctctccc ttaggcttgg     5820

gcaaggcagc cacctgccct tgctctccct tagtgttccc tggcctccct gccatcaggt     5880

tgctgggagt ggagatggag ggattattga gcagaaaatg agttggatgg agataaacag     5940

ctcccatccc tgggtaatgg atggtaagat gatggagatt cctaagattg gtggagttgg     6000

gcaatgcata gccatctgac tccttcaggg tgctcttgat gggctggctg taagggagac     6060

tcagtcccag cctctcccct ctacaactcc tgccactgtt ggccatgtcg taaggcagca     6120

gctgtgccag gatagctggg tccattcaga gcaccttgag aagtgttgca gggaggtgtt     6180

aagaagagaa ctctgtgcaa acagtgatgg aaggctgttg tcttggtgta tcccttgcct     6240

catagtcaat atattttttt tttggcgagt caccagtgac ccgagccctc cacaccagcc     6300

tcctgtatct catcaggtcc cttctcagta ctgtatttgc tcagtgcatc aggaatgggt     6360

gtatgggtgt gtgtgggtgg gtgtgagtgt gggtgtgtac gtaccaataa acaacctggt     6420

tttaagacaa tgta                                                       6434


<210> 1591
<211> 3970
<212> DNA
<213> Homo sapiens

<400> 1591
gttgtcgggt cttattggcc gctgattaga ccagccgggg tccactagcc ctgggcttca       60

gggaggctgc tgcgtccagt gaacacttca gcacctgtag cacagaaggg ccaaggagct      120

gcagtcctcg accagcagga ggtttgctcc tcagcccact cgctgcatcc agatcagctc      180

acccctctcc cttccctgcc caccaggact ctgatagccc ctggcagcca cagcccattt      240

tgccaagatg tctagagtag ccaaatatcg ccggcaggtg agtgaagacc ccgacatcga      300

cagcctgctg gagaccctgt ctcccgagga gatggaggag ctggagaagg agctggacgt      360

ggtggaccca gacgggagtg ttcccgtggg gctgcggcag agaaaccaga cggagaaaca      420

gtccacgggt gtgtacaacc gggaggccat gctcaacttc tgtgaaaagg agaccaagaa      480

acttatgcag agggagatgt ccatggatga aagcaagcaa gtggagacca agacagatgc      540

caagaatgga gaggaaaggg gcagagatgc cagcaaaaaa gccctgggcc ccagacggga      600

ctcagatctg gggaaggagc caaagagggg tggtttaaag aaaagcttct ctagagacag      660

agatgaagct ggtggcaaga gtggcgagaa gcccaaggag gagaagatca tccggggcat      720

tgacaagggc cgggtcaggg ctgcagtgga taagaaggag gcagggaagg atgggagagg      780

agaggagagg gcagtggcca ccaagaagga agaggagaag aaagggagtg acaggaacac      840

aggcttgagc agggacaagg ataaaaagag agaggagatg aaggaggtgg ccaagaaaga      900

ggatgatgag aaggtaaaag gggagcgtag gaacacagac accagaaaag agggtgagaa      960

gatgaaaaga gcaggtggga acacagacat gaaaaaggag gatgagaagg taaaaagagg     1020

aactgggaac acagacacca aaaaggacga tgaaaaagtc aagaagaatg aacccttaca     1080

tgaaaaggaa gccaaggatg acagcaagac caaaacaccc gagaaacaga cgcccagtgg     1140

ccccaccaag ccctctgaag gaccggccaa ggtggaggag gaggcagctc ccagcatatt     1200

tgatgagcct ctggagagag tgaagaacaa tgaccccgag atgactgagg tgaacgtcaa     1260

caactcagac tgcatcacaa atgagatctt ggtccggttt actgaggctc tggagttcaa     1320

cactgtggtt aagctgttcg ccttggccaa cacgcgagcc gatgaccacg tggcctttgc     1380

cattgccatc atgctcaagg ccaacaagac catcaccagc ctcaacctgg actccaacca     1440

catcacaggc aaaggcatcc tggccatctt ccgggccctc ctccagaaca acacgctgac     1500

cgagctccgc ttccacaacc agcgacacat ctgtggaggc aagacggaga tggagatcgc     1560

caagctgctg aaggagaata ctaccctgct caagctgggc taccattttg agctggccgg     1620

gccccgaatg actgtcacca atctgctcag ccgcaacatg gacaagcaga gacaaaagcg     1680

gctgcaggag caaaggcagg cacaggaagc caagggagag aagaaggatc tgctggaggt     1740

acccaaggcc ggggccgtgg ctaagggctc cccaaaacct tcacctcaac catctccaaa     1800

gccctctcca aagaactcac ccaaaaaagg gggtgctcca gctgccccac caccccctcc     1860

ccctcccttg gctccacccc ttatcatgga gaacctgaag aattcactct caccagctac     1920

ccagaggaag atgggagaca aagtcctccc tgcccaggag aagaactccc gtgaccagct     1980

attggctgcc atccgctcca gcaacctcaa gcagctcaag aaggtggaag tgcccaaact     2040

gcttcagtag gaccaggctg ccaggcacca tctgccaatg ccatgactgc tcaggcctca     2100

cctcccaggg ctacacagac cctgcccacc ccatccctgg ctgacctgct gtggatgtcc     2160

ctattctgcc atgggagagt ccaggcctgg gtcacgctca aggaaggatg ccttatctct     2220

tctcactttc cttttcttgt ctctgaggct ctccaaattt tgctttagta catggagctc     2280

aggtttctgg acaagaagag tccttttagc acatcactga gaagatggca ctgtccaggg     2340

cccatgtagc tggcaagctg caaaaggcct gtgatccagg aaagatgtcc cacagggacc     2400

acatccaccc cagccccact gccctccagg gccaggattc aggcctctga ggagcccacg     2460

gggcaaagct gctgggccag tggcactctg tgtgggaaaa tggcagaaag atggagaggc     2520

atgggggccc aaaggggagc gtggggaggg gctgaggata ccccaaagtc caggctaatt     2580

agaggatgtg gcaggggcag tggcctggat gcacagtgcc tgatgggagt aggctccaga     2640

caggaggagt gggacagaca gcagctggac ttgaaggttt gatgccaaag cagacatttt     2700

cctcacaccc acctgctgct gtatgaatag ctgtgtatct gtttttccat aagattttga     2760

taatatatac aaacctttag ctgtgaatgg ctgtgcccca cctgttgtcc tgaactgtga     2820

gtcctgatcc taaccctggg ctccctggag gactctagaa gctcaggttc cctgccacac     2880

tatttgagtt ggccaagaaa taaattcaca tcctcagaaa gtgcagcatg gaggaaaatc     2940

tgaactctaa gcagaagact ctccactgac ctggttgtcc aggtctagaa ggccaggcct     3000

ctactaggtc tgctcctgaa ccagtcctgc tgcctggagt cagtagccag agttgttctc     3060

aggggtgctg gggcagagtg gagcccaggg tgctgggatg gctatattag gcatgttcag     3120

ggatgctcat tccatgactc tgcctaacca tgggctcagg gccaggtcct cacagcagtc     3180

acaggcccag gaaggcggca ggcagagaag tggagtgact atttggagaa tagcacccat     3240

atctgtgtgc cctagggctc agaggggcct catcttcccc agccctcccc acctgctcac     3300

caattccact tcctgcccca actgcaggaa tgctgacaat gctgccatgc ccaccatcgg     3360

gtgtaggtga aaggcatctt tctgaatttc attctcttga aggtgctgcc accccttggc     3420

actgtggaac tgccaccttg ggtctgtgtc acttgtaggt ttctctgcct ccaggttgcc     3480

tcaacagcag gaggcacagc agtttcacca tctttgaggt gagggtgggg tgccccagct     3540

aggaagcaag atcgctgtgc taggtctgac caaaaccaga gggcagtcta gtcctggggg     3600

taaagccctc agatcccagg gtacactctt ctccattccc tccacccact tgcctgtcac     3660

cccagtcacc taagcaatca ctgggcccag aggagaggag acagacacac actggctcct     3720

ggacctaaag ggtatgagct ggagctaagg ccagctagag cttccactgt cagccctcac     3780

tgtcagtccc actgcacccc cctgtgcctg ctgggcactg ggcactagct agatgcttta     3840

ggttgcttca gctgatcctt caactctgtg aggtggatac caatattcta ttttgcagat     3900

agaatttggc ccagagaggt taactaatat atccatgatc acacagctaa taaaagtcag     3960

agctcaggtc                                                            3970


<210> 1592
<211> 1096
<212> DNA
<213> Homo sapiens

<400> 1592
ccactccgca ccccaccctc tgtctggtac agcttaccaa accaaagtgc ccaaagccgt       60

gacatcccgg ccggcggctc gcaggccccc gccctccgca cgtcacggcc gccgggtgca      120

gtgcccccta ggggcccctg ggacgaggag gaagcgccag gtccttcccg ccgccgccgc      180

cgccgccgcc gcctgctccc ctggcacgcg ccccgccgcc ctcggcagcc gcagctccgt      240

gtcccctgag aaccagccgt cccgcgccat gggcacgcgt ctgccgctcg tcctgcgcca      300

gctccgccgc ccgccccagc ccccgggccc tccgcgccgc ctccgtgtgc cctgtcgcgc      360

tagcagcggc ggcggcggag gcggcggcgg tggccgggag ggcctgcttg gacagcggcg      420

gccgcaggat ggccaggccc ggagcagctg cagccccggc ggccgaacgc ccgcggcgcg      480

ggactccatc gtcagagaag tcattcagaa ttcaaaagaa gttctaagtt tattgcaaga      540

aaaaaaccct gccttcaagc cggttcttgc aattatccag gcaggtgacg acaacttgat      600

gcaggaaatc aaccagaatt tggctgagga ggctggtctg aacatcactc acatttgcct      660

ccctccagat agcagtgaag ccgagattat agatgaaatc ttaaagatca atgaagatac      720

cagagtacat ggccttgccc ttcagatctc tgagaacttg tttagcaaca aagtcctcaa      780

tgccttgaaa ccagaaaaag atgtggatgg agtaacagac ataaacctgg ggaagctggt      840

gcgaggggat gcccatgaat gttttgtttc acctgttgcc aaagctgtaa ttgaacttct      900

tgaaaaatca ggtgtcaacc tagatggaaa gaagattttg gtagtggggg cccatgggtc      960

tttggaagct gctctacaat gcctgttcca gagaaaaggg tccatgacaa tgagcatcca     1020

gtggaaaaca cgccagcttc aaagcaagac ggagtctcgt tctgtcacca ggctggagtg     1080

caggcgcgtg atctag                                                     1096


<210> 1593
<211> 996
<212> DNA
<213> Homo sapiens

<400> 1593
gtggccggga gggcctgctt ggacagcggc ggccgcagga tggccaggcc cggagcagct       60

gcagccccgg cggccgaacg cccgcggcgc gggactccat cgtcagagaa gtcattcaga      120

attcaaaaga agttctaagt ttattgcaag aaaaaaaccc tgccttcaag ccggttcttg      180

caattatcca ggcaggtgac gacaacttga tgcaggaaat caaccagaat ttggctgagg      240

aggctggtct gaacatcact cacatttgcc tccctccaga tagcagtgaa gccgagatta      300

tagatgaaat cttaaagatc aatgaagata ccagagtaca tggccttgcc cttcagatct      360

ctgagaactt gtttagcaac aaagtcctca atgccttgaa accagaaaaa gatgtggatg      420

gagtaacaga cataaacctg gggaagctgg tgcgagggga tgcccatgaa tgttttgttt      480

cacctgttgc caaagctgta attgaacttc ttgaaaaatc agtaggtgtc aacctagatg      540

gaaagaagat tttggtagtg ggggcccatg ggtctttgga agctgctcta caatgcctgt      600

tccagagaaa agggtccatg acaatgagca tccagtggaa aacacgccag cttcaaagca      660

agcttcacga ggctgacatt gtggtcctag gctcacctaa gccagaagag attcccctta      720

cttggataca accaggaact actgttctca actgctccca tgacttcctg tcagggaagg      780

ttgggtgtgg ctctccaaga atacattttg gtggactcat tgaggaagat gatgtgattc      840

tccttgctgc agctctgcga attcagaaca tggtcagtag tggaaggaga tggcttcgtg      900

aacagcagca caggcggtgg agacttcact gcttgaaact tcagcctctc tcccctgtgc      960

caagtgacat tgagatttca agaggacaaa ctccaa                                996


<210> 1594
<211> 3604
<212> DNA
<213> Homo sapiens

<400> 1594
tgagtcccac tccgcacccc accctctgtc tggtacagct taccaaacca aagtgcccaa       60

agccgtgaca tcccggccgg cggctcgcag gcccccgccc tccgcacgtc acggccgccg      120

ggtgcagtgc cccctagggg cccctgggac gaggaggaag cgccaggtcc ttcccgccgc      180

cgccgccgcc gccgccgcct gctcccctgg cacgcgcccc gccgccctcg gcagccgcag      240

ctccgtgtcc cctgagaacc agccgtcccg cgccatgggc acgcgtctgc cgctcgtcct      300

gcgccagctc cgccgcccgc cccagccccc gggccctccg cgccgcctcc gtgtgccctg      360

tcgcgctagc agcggcggcg gcggaggcgg cggcggtggc cgggagggcc tgcttggaca      420

gcggcggccg caggatggcc aggcccggag cagctgcagc cccggcggcc gaacgcccgc      480

ggcgcgggac tccatcgtca gagaagtcat tcagaattca aaagaagttc taagtttatt      540

gcaagaaaaa aaccctgcct tcaagccggt tcttgcaatt atccaggcag gtgacgacaa      600

cttgatgcag gaaatcaacc agaatttggc tgaggaggct ggtctgaaca tcactcacat      660

ttgcctccct ccagatagca gtgaagccga gattatagat gaaatcttaa agatcaatga      720

agataccaga gtacatggcc ttgcccttca gatctctgag aacttgttta gcaacaaagt      780

cctcaatgcc ttgaaaccag aaaaagatgt ggatggagta acagacataa acctggggaa      840

gctggtgcga ggggatgccc atgaatgttt tgtttcacct gttgccaaag ctgtaattga      900

acttcttgaa aaatcaggtg tcaacctaga tggaaagaag attttggtag tgggggccca      960

tgggtctttg gaagctgctc tacaatgcct gttccagaga aaagggtcca tgacaatgag     1020

catccagtgg aaaacacgcc agcttcaaag caagcttcac gaggctgaca ttgtggtcct     1080

aggctcacct aagccagaag agattcccct tacttggata caaccaggaa ctactgttct     1140

caactgctcc catgacttcc tgtcagggaa ggttgggtgt ggctctccaa gaatacattt     1200

tggtggactc attgaggaag atgatgtgat tctccttgct gcagctctgc gaattcagaa     1260

catggtcagt agtggaagga gatggcttcg tgaacagcag cacaggcggt ggagacttca     1320

ctgcttgaaa cttcagcctc tctcccctgt gccaagtgac attgagattt caagaggaca     1380

aactccaaaa gctgtggatg tccttgccaa ggagattgga ttgcttgcag atgaaattga     1440

aatctatggc aaaagcaaag ccaaagtacg tttgtccgtg ctagaaaggt taaaggatca     1500

agcagatgga aaatacgtct tagttgctgg gatcacaccc acccctcttg gagaagggaa     1560

gagcacagtc accatcgggc ttgtgcaggc tctgaccgca cacctgaatg tcaactcctt     1620

tgcctgcttg aggcagcctt cccaaggacc gacgtttgga gtgaaaggag gagccgcggg     1680

tggtggatat gcccaggtca tccccatgga ggagttcaac cttcacttga ctggagacat     1740

ccacgccatc accgctgcca ataacttgct ggctgccgcc atcgacacga ggattcttca     1800

tgaaaacacg caaacagata aggctctgta taatcggctg gttcctttag tgaatggtgt     1860

cagagaattt tcagaaattc agcttgctcg gctaaaaaaa ctgggaataa ataagactga     1920

tccgagcaca ctgacagaag aggaagtgag taaatttgcc cgtctcgaca tcgacccatc     1980

taccatcacg tggcagagag tattggatac aaatgaccga tttctacgaa aaataaccat     2040

cgggcaggga aacacagaga agggccatta ccggcaggcg cagtttgaca tcgcagtggc     2100

cagcgagatc atggcggtgc tggccctgac ggacagcctc gcagacatga aggcacggct     2160

gggaaggatg gtggtggcca gtgacaaaag cgggcagcct gtgacagcag atgatttggg     2220

ggtgacaggt gctttgacag ttttgatgaa agatgcaata aaaccaaacc tgatgcagac     2280

cctggaaggg acacctgtgt tcgtgcatgc gggccctttt gctaacattg ctcacggcaa     2340

ctcttcagtg ttggctgata aaattgccct gaaactggtt ggtgaagaag gatttgtagt     2400

gaccgaagct ggctttggtg ctgacatcgg aatggagaaa ttcttcaaca tcaagtgccg     2460

agcttccggc ttggtgccca acgtggttgt gttagtggca acggtgcgag ctctgaagat     2520

gcatggaggc gggccaagtg taacggctgg tgttcctctt aagaaagaat atacagagga     2580

gaacatccag ctggtggcag acggctgctg taacctccag aagcaaattc agatcactca     2640

gctctttggg gttcccgttg tggtggctct gaatgtcttc aagaccgaca cccgcgctga     2700

gattgacttg gtgtgtgagc ttgcaaagcg ggctggtgcc tttgatgcag tcccctgcta     2760

tcactggtcc gttggtggaa aaggatcggt ggacttggct cgggctgtga gagaggctgc     2820

gagtaaaaga agccgattcc agttcctgta tgatgttcag gttccaattg tggacaagat     2880

aaggaccatt gctcaggctg tctatggagc caaagatatt gaactctctc ctgaggcaca     2940

agccaaaata gatcgttaca ctcaacaggg ttttggaaat ttgcccatct gcatggcaaa     3000

gacccacctt tctctatctc accaacctga caaaaaaggt gtgccaaggg acttcatctt     3060

acctatcagt gacgtccggg ccagcatagg cgctgggttc atttaccctt tggtcggaac     3120

gatgagcacc atgccaggac tgcccacccg gccctgcttt tatgacatag atcttgatac     3180

cgaaacagaa caagttaaag gcttgttcta agtggacaag gctctcacag gacccgatgc     3240

agactcctga aacagactac tctttgcctt tttgctgcag ttggagaaga aactgaattt     3300

gaaaaatgtc tgttatgcaa tgctggagac atggtgaaat aggccaaaga tttcttcttc     3360

gttcaagatg aattctgttc acagtggagt atggtgttcg gcaaaaggac ctccaccaag     3420

actgaaagaa actaatttat ttctgtttct gtggagtttc cattatttct actgcttaca     3480

ctttagaatg tttattttat ggggactaag ggattaggag tgtgaactaa aaggtaacat     3540

tttccactct caagttttct actttgtctt tgaactgaaa ataaacatgg atctagaaaa     3600

ccaa                                                                  3604


<210> 1595
<211> 746
<212> DNA
<213> Homo sapiens

<400> 1595
ttcccagaaa tacatttgcc accaacagag tagccaaatt tataaggaaa aatgattccc       60

aatggatatt tgatgtttga ggatgaaaat tttattgagt cttctgttgc caaattaaat      120

gccctgagga aaagtggcca gttctgtgat gttcgacttc aggtctgtgg ccatgaaatg      180

ttagcacaca gagcagtgct agcttgctgc agtccctatt tatttgaaat ctttaatagt      240

gatagtgatc ctcatggaat ttctcacgtt aaatttgatg atctcaatcc agaagctgtt      300

gaagtcttgt tgaattatgc ctacactgct cagttgaaag cagataagga attggtaaaa      360

gatgtttatt ctgcagcaaa aaagctgaag atggatcgag taaagcagca tcttctctac      420

ttctgtctgc attcaacatc aacatcatct ctcctgtaga gcccagttca gatactgcgt      480

ttcatgaagc cttaccaaat tattctactt gaaaatactt atgtgaactt acatagcatt      540

tcaatttgtt gtacctctcc ttaaactaaa acttacatat ctgtatggca taattagatg      600

tttatcattt gtatacgtgt tattaccact attaacattt gttgtattaa gacagtgatt      660

tttgattctt tgtatcttca catagtcttt accacactga acattaaata tttgttgaat      720

aaaagatatg taagtgttgg cactca                                           746


<210> 1596
<211> 4199
<212> DNA
<213> Homo sapiens

<400> 1596
gaagcgggct gggaggcgtc ggcggcggca gcgcacgtgg tgacgtgcga gggggtgcgg       60

cgcgagcggt cggcggcggc ggaggcagtg tctcccggtc gcgcgtggag gtcggtcgct      120

cagagctgct gggcgcagtt tctccgcctg ctgcttcggc gcggctgtat cggcgagcga      180

gcgagttccc gcgagttctc ggtggcgctc ccccttcctt tcagtctcca cggactggcc      240

cctcgtcctt ctacttgacc gctcccgtct tccgccgcct tctggcgctt tccgttgggc      300

cgattcccgc ccgcttcctc ctgcttccca tcgaagctct agaaatgaat gtttccatct      360

cttcagagat gaaccagatt atgatgcatc attatcacag aagaaattcg tgtctatagc      420

ttttaaggac ttgattacat cattttcaag cctgatagtt ttggaatcac cattagagct      480

taagacacac ctgccttcat ttcaaccacc tgtcttcata ccctgacgaa gtgcaccttt      540

taacactcct ttgtccttgg attacttaag agttcccaga aatacatttg ccaccaacag      600

agtagccaaa tttataagga aaaatgattc ccaatggata tttgatgttt gaggatgaaa      660

attttattga gtcttctgtt gccaaattaa atgccctgag gaaaagtggc cagttctgtg      720

atgttcgact tcaggtctgt ggccatgaaa tgttagcaca cagagcagtg ctagcttgct      780

gcagtcccta tttatttgaa atctttaata gtgatagtga tcctcatgga atttctcacg      840

ttaaatttga tgatctcaat ccagaagctg ttgaagtctt gttgaattat gcctacactg      900

ctcagttgaa agcagataag gaattggtaa aagatgttta ttctgcagca aaaaagctga      960

agatggatcg agtaaagcag gtttgtggtg attatttact gtctagaatg gatgttacca     1020

gctgcatctc ttaccgaaat tttgcaagtt gtatgggaga ctcccgtttg ttgaataagg     1080

ttgatgctta tattcaggag catttgttac aaatttctga agaggaggag tttcttaagc     1140

ttccaaggct aaagttggag gtaatgcttg aagataatgt ttgcttgccc agcaatggca     1200

aattatatac aaaggtaatc aactgggtgc agcgtagcat ctgggagaat ggagacagtc     1260

tggaagagct gatggaagag gttcaaacct tgtactactc agctgatcac aagctgcttg     1320

atgggaacct actagatgga caggctgagg tgtttggcag tgatgatgac cacattcagt     1380

ttgtgcagaa aaagccacca cgtgagaatg gccataagca gataagtagc agttcaactg     1440

gatgtctctc ttctccaaat gctacagtac aaagccctaa gcatgagtgg aaaatcgttg     1500

cttcagaaaa gacttcaaat aacacttact tgtgcctggc tgtgctggat ggtatattct     1560

gtgtcatttt tcttcatggg agaaacagcc cacagagctc accaacaagt actccaaaac     1620

taagtaagag tttaagcttt gagatgcaac aagatgagct aatcgaaaag cccatgtctc     1680

ctatgcagta cgcacgatct ggtctgggaa cagcagagat gaatggcaaa ctcatagctg     1740

caggtggcta taacagagag gaatgtcttc gaacagtcga atgctataat ccacatacag     1800

atcactggtc ctttcttgct cccatgagaa caccaagagc ccgatttcaa atggctgtac     1860

tcatgggcca gctctatgtg gtaggtggat caaatggcca ctcagatgac ctgagttgtg     1920

gagagatgta tgattcaaac atagatgact ggattcctgt tccagaattg agaactaacc     1980

gttgtaatgc aggagtgtgt gctctgaatg gaaagttata catcgttggt ggctctgatc     2040

catatggtca aaaaggactg aaaaattgtg atgtatttga tcctgtaaca aagttgtgga     2100

caagctgtgc ccctcttaac attcggagac accagtctgc agtctgtgag cttggtggtt     2160

atttgtacat aatcggaggt gcagaatctt ggaattgtct gaacacagta gaacgataca     2220

atcctgaaaa taatacctgg actttaattg cacccatgaa tgtggctagg cgaggagctg     2280

gagtggctgt tcttaatgga aaactgtttg tatgtggtgg ctttgatggt tctcatgcca     2340

tcagttgtgt ggaaatgtat gatccaacta gaaatgaatg gaagatgatg ggaaatatga     2400

cttcaccaag gagcaatgct gggattgcaa ctgtagggaa caccatttat gcagtgggag     2460

gattcgatgg caatgaattt ctgaatacgg tggaagtcta taaccttgag tcaaatgaat     2520

ggagccccta tacaaagatt ttccagtttt aacaaattta agaccctctc aaactaacag     2580

gcttagtgat gtaattatgg ttagtagagg tacacttgtg aataaagagg gtgggtgggt     2640

atagatgttg ctaacagcaa cacaaagctt ttgcatattg catactatta aacatgctgt     2700

acatactttt tgggtttatt tggaaaggaa tgcaaagatg aaggtctgtt ttgtgtactt     2760

ttaagacttt ggttatttta ctttttggaa aagaataaac caagaattga ttgggcacat     2820

catttcaaga agtcccctct cctccacatt tgttttgcca atttgcacat taaatgactc     2880

ttccctcaaa tgtgtactat ggggtaaaag gggtagggtt taaagatgta gacagttggg     2940

ttttttaagg gccctttttc aataactgga acactctata acaaaggata cttatttaaa     3000

tagatgacat tgactatttt tgtttttatt aaaaggaagc ttacatgcct accaatattt     3060

aatcttttat gattgccttt ttataacttt ttatattctc agcagagtgc tttaccaatt     3120

gaagtaaaat gtggcaggct ggagttattg aagcagagtg gcagtcttca gtttgcagag     3180

taggggtctg tcttttaaac tctgagtgca aacttcagag ttcttgcctt ggctgcagtt     3240

tttttccttc aagaatgcag tactaacatt tatttgagtg gagttactga acagtaacat     3300

agctgtgatt tttggtattt gaaacactgg ttttaaatat tttgacttgt tgagggtatg     3360

ttttatatag caagacatta tatagcagta aaaaatggtg ttttatcttc tatataattc     3420

ctgtttttat tattaacaaa acagtcctaa atagcagccc tcaattgtga aaaaatttac     3480

tttaaactac attaggttgt gaatgcaggt tttatcagaa ctatgttttt gttcagttta     3540

tctgttcata tggataaata ttggttggga tgacttggtg tctaatgtgt agtgctacac     3600

acctaactta tggggccaaa atagcatgtc ctaatgcttg ctgctgattt aaacacatta     3660

aaggtacttt gcaggaaatc cttgcaccat gggattaata tccaattgct gcttgtacac     3720

tcattcatta ctaaaagttt tgagaaattt ttttttccag taatgagctt aagaaatttg     3780

tggaaaataa ctcacctggc atcttacatc tgaaataagg aatgatataa ggtttttttt     3840

tctcacagaa gatgaagcac acaggaacct aatgggccaa ctgggatgag gtgactattc     3900

tgagatgact attcagtggc taacttgggt taggaagaaa ataattaggt attttctcca     3960

aatgttcact ggtactctgc cactttattt ctctcatctg ttacacaaag aaccaccagg     4020

aaagcaaatc agtttggttg gtaactctgt aattcctaac tatcactggt ttggttctgg     4080

actaaaacta cattgacaga ttgaatttgc ctaatatgat gactgttttt aatatggatc     4140

tgtatgtgtt ctattcagca caaggaaata aaattttagt tgaggattca gcactaaaa      4199


<210> 1597
<211> 622
<212> DNA
<213> Homo sapiens

<400> 1597
ctttgccgct ggtcgggatt gggatgtcga agaacacagt gtcgtcggcc cgcttccgga       60

aggtggacgt ggatgaatat gacgagaaca agttcgtgga cgaagaagat gggggcgacg      120

gccaggccgg gcccgacgag ggcgaggtgg actcctgcct gcggcaagga aacatgacag      180

ctgccctaca ggcagctctg aagaaccccc ctatcaacac caagagtcag gcagtgaagg      240

accgggcagg cagcattgtc ttgaaggtgc tcatctcttt taaagctaat gatatagaaa      300

aggcagttca atctctggac aagaatggtg tggatctcct aatgaagtat atttataaag      360

gatttgagag cccgtctgac aatagcagtg ctatgttact gcaatggcat gaaaaggtgc      420

ctcttgtatg attccagata tggaggaggc ccgggaagcc cacagaggta cagcatgtca      480

tctgcctcaa ggtggtgcta cttcaccaca ttgatgatcc aaccacaagc aacatgggac      540

acagcattca ctttaacatt tctattttcc tttatcattt ctgttacttg agtgtgtaag      600

agtaatcaac ataaataatc ta                                               622


<210> 1598
<211> 1670
<212> DNA
<213> Homo sapiens

<400> 1598
gggctgtttg gaggcgcttg gggcgcacaa tctggggcag gcggaacctt agtcctcagc       60

ctcgcgtttc ccgcgactcc gctctcaccg ctacactacc acacaaacgg cctccttccc      120

ccacccccgg gggcccatcc cggtggcggg ctccggagct cgggactgct aatttcagcg      180

aaacgattaa aagacgcccc tacagctgac ggcactttct ctcctccggc agggaaggac      240

gtccagcgta gcgtcgcccg cgcttccccg ccggcgcaga gcaggcctca cagaatcgca      300

cgccgctggc acgcacgccg ccccgccccc acggcccagc gccagccgcg ccccgcgctc      360

gcacgcatcc cggcctcact gcccctcgac tcctgttccg ttggaggggc ctgaggcgag      420

cctgagcgcg ctgttggccg gagggaagcc ggaggagacc gggtcgactg ggcagagcgg      480

cagagggtcg aggagcctgc tctgcacgcc cagggagtag aagtgggcag ggagcagggt      540

cacgtgaggg agcgcgccgc gactgagctt gggtccgact ggagctcagg ctcgcgaccc      600

agactggtgg gccaggcctc caagccggcc ttacacccaa tccaaggagg acagaccgga      660

cacagaggga cggagcgagc aaggagacat ggcttcatca ttcctgcccg cgggggccat      720

caccggcgac agcggtggag agctgagctc aggggacgac tccggggagg tggagttccc      780

ccatagccct gagatcgagg agaccagttg cctggccgag ctgtttgaga aggctgccgc      840

gcacctgcaa ggcctgattc aggtggccag cagggagcag ctcttgtacc tgtatgccag      900

gtacaaacag gtcaaagttg gaaattgtaa tactcctaaa ccaagcttct ttgattttga      960

aggaaagcaa aaatgggaag cttggaaagc acttggtgat tcaagcccca gccaagcaat     1020

gcaggaatat atcgcagtag ttaaaaaact agatccaggt tggaatcctc agataccaga     1080

gaagaaagga aaagaagcaa atacaggttt tggtgggcca gttattagtt ctctatatca     1140

tgaagaaacc atcagggaag aagacaaaaa tatatttgat tactgcaggg aaaacaacat     1200

tgaccatata accaaagcca tcaaatcgaa aaatgtggat gtgaatgtga aagatgaaga     1260

gggtagggct ctacttcact gggcctgtga tcgaggacat aaggaactag tcacagtgtt     1320

gctgcaacat agagctgaca ttaactgtca ggacaatgaa ggccaaacag ctctacatta     1380

tgcctctgcc tgtgagtttc tggatattgt agagctgctg ctccagtctg gtgctgaccc     1440

cactctccga gaccaggatg gctgcctgcc agaggaggtg acaggctgca aaacagtttc     1500

tttggtgctg cagcggcaca caactggcaa ggcttaatca aaagactgga aaactgcagt     1560

ctgtaatagc ataaggcttc cattatgaaa gaaaactaca aaaataatac ttcttttcca     1620

cccgtctttg gtatgtattg gctaataaaa tcagttctgt ggaactggga                1670


<210> 1599
<211> 13491
<212> DNA
<213> Homo sapiens

<400> 1599
gcccgactgc tcccgccctg cctcgcgccg ccgccacagc cgctgccgct ggcgccgctc       60

ctcctccgtg tcagttgttg ggctgtaatg gcgactgggc cgcccctgac gaagtgactc      120

ccgggccggg gagcggggcc agacctgcgc cagagagaac tgcagggagc cgcagctcgg      180

ggggtggctt gccctgaggg aggggaggca gcctttccgc cttgtcttcc ttcccagcgg      240

accggcggat ccccggagcc ggtgcgagga gggcacccgg tgcgtccccg gagcggggag      300

gccaggccgg gcagccctgg ggccggtcgg ggcggcgtca ctgcaccctc cgccaggctc      360

cgcgggatgc accgtggtag ccgagggcgg aggcgacact ctcaggtaaa ttggcaggat      420

gaggagcagc aaatcaaaag aggtgccttt accaaatcca aggaactctc aaagcaagga      480

tactgttcaa gcagatataa ccacatcgtg ggatgcactt tctcaaacca aggctgctct      540

gagacacatt gaaaataaat tagaagtagc ccctacaagt acagctgtgt gtgattctgt      600

catggatacc aagaagtctt ctacaagtgc tactcgaaaa ataagtagaa aagatggtag      660

atacctggat gattcttggg ttaatgctcc aatctccaaa tccactaaat cacgaaaaga      720

gaaatctcgt agtcctctca gggccaccac cctggagagt aatgtgaaga aaaataatcg      780

tgtggaattt cgtgaacctt tggtttctta tagggaaatc catggtgcac cttccaattt      840

cagttccagc catctggaat caaagcacgt atactgtgta gatgttaatg aagaaaagac      900

tgagagcggt aactggatga taggcagtcg agaagaacgg aatatacgga gctgtgattt      960

tgagagctcc caatcatctg tcatcaatga tacagttgtt aggtttttaa atgatcgacc     1020

agcaattgat gcattgcaaa attctgaatg tttgattagg atgggagctt ctatgagaac     1080

tgaggaagaa atgcctaaca gaacaaaagg aagtgagaat aatttgaagc tttctgtgaa     1140

taacatggcc catgatactg atccaaaagc gttacgacta actgactctt ctccatcctc     1200

tactagtact tctaattccc aaagattaga tattctaaag cggcgacaac atgatgtcaa     1260

actggaaaaa cttaaggaac ggattagaaa acagtgggaa cactcagaag aaacaaatgg     1320

ccggggccag aagctgggtc atattgacca tccagtaatg gttgttaatg ttgataactc     1380

agtaacagca aaagtcagaa aagtggcaac agcaccacct gctccagcat ataaaggttt     1440

caacccttca gagaccaaga ttcgaacacc tgatgggaaa gtgtggcagg aggctgagtt     1500

tcaaaacatg agtagagaac tgtatcgaga tttagcactt cactttgcag atgatatttc     1560

tataaaggag aaacctgctg aaaaaagtaa agagaagaaa gtagtcaagc cagtacgaaa     1620

agtccaaaaa gtagcacagt tatcaagtac agaatgcaga acaggtagta gtcatcttat     1680

aagtacatct tcttggcgag atggacaaaa attagtaaag aagattctgg gacctgctcc     1740

cagaatggag ccaaaagagc aaagaacagc atcaagtgac agaggtggaa gagaaagaac     1800

tgctaaatct gggggtcaca ttggaagagc agaatctgat cccaggttgg acgttttaca     1860

tagacatctt caaagaaact cagaacgttc gagaagtaaa tctcggtctg aaaataatat     1920

aaagaaacta gcttcatctc ttccagataa taagcaggag gaaaatactg ccttaaataa     1980

ggacttttta cctattgaaa ttcgtggcat tcttgatgac ctacagctgg attctacagc     2040

tcacactgca aagcaagata ctgtagagtt acagaaccag aagtcatcag caccagtaca     2100

tgctcctagg agtcacagcc cagtaaaaag aaaacctgac aaaataacag ctaatgaaga     2160

tccccctgtt atttccaaaa ggcgccacta tgacacagat gaggtacgac agtacattgt     2220

taggcagcag gaggaaagga agagaaagca aaatgaagag aagaaggctc aaaaggaggc     2280

tacagaacag aaaaacaaac gattacaaga gctctaccgg aagcagaagg aagcctttac     2340

taaagtaaaa aatgtccctc cttctgagcc atcagcaact aggcgactac aggaaactta     2400

ctccaaattg ctactagaaa agaccttgct tgaagagcca tctcatcaac atgttacgca     2460

ggaaacacag gccaaaccag ggtatcagcc atctggagaa tctgacaaag aaaacaaagt     2520

acaggaacgt cccccaagtg catcttccag tagtgacatg tctctctcag aacctccaca     2580

gcctcttgca agaaaagact tgatggaatc tacatggatg cagcctgaaa gattgagccc     2640

acaagttcac cattctcaac cacagccttt tgctggaaca gctggaagtt tactctccca     2700

tctcttgagt ttagagcatg taggaatttt gcataaggat tttgaatcta ttttaccaac     2760

caggaagaat cataatatgg cttcaaggcc attaactttt acacctcaac catatgtgac     2820

ctcaccagct gcttatacag atgccttgtt aaaacctagt gccagccaat ataagagtaa     2880

actggatcgt attgaagcct tgaaagcaac agctgcttct ttgtccagca gaattgaaag     2940

tgaagccaag aaattagctg gggccagcat taactatggg tcagcatgga acactgagta     3000

tgatgtgcag caggcacctc aagaagatgg accttggacc aaggctgtaa ctccacctgt     3060

gaaagatgat aatgaagatg ttttctctgc cagaattcag aagatgctgg gaagctgtgt     3120

atctcatgca acttttgatg atgatcttcc tggtgtaggc aatcttagtg aatttaaaaa     3180

gcttcctgag atgataagac cacagagtgc catatcaagc tttagagtga gatcccctgg     3240

tcccaaacca gaagggctac tggcacagtt atgtaaaagg cagactgact cttctagctc     3300

tgatatgcaa gcctgttctc aagacaaagc caaaatatct cttggttcca gcatagattc     3360

agtcagtgaa gggcctcttc ttagtgaggg gagtctctct gaagaagagg gagaccagga     3420

tggacagccc cttttgaaag tagcagaaat tttaaaagaa aaggaatttt gtcctggaga     3480

aagaaatagt tatgaaccca tcaaagagtt tcagaaagaa gctgaaaaat tcttgccact     3540

ttttgggcac ataggtggta cacaaagcaa aggaccatgg gaagaattgg caaagggaag     3600

tccacatagc gtcattaata tttttacaaa atcctatcag ttatatggaa aagggtttga     3660

agacaagttg gacagaggaa catcaacatc acggcctttg aatgccaccg caactcctct     3720

aagtggtgtt tcatatgaag atgattttgt ctcctctcca gggactggga cttcgacaga     3780

aaaaaaatca actcttgaac ctcatagcac tttaagccct caggaggacc attctaacag     3840

aaagtctgcc tatgatcctt cctctgtgga tgttacctcc cagcattcat caggagccca     3900

gtctgctgca tcgtctcgtt catctacttc ttctaaagga aagaaaggaa aaaaggaaaa     3960

gacagaatgg ttggattcat tcactggaaa tgttcagaac tcacttcttg atgaggaaaa     4020

agcagaacgt ggctcccatc aaggaaagaa atctgggacc agcagcaaac tttctgttaa     4080

agattttgag cagactcttg atacagatag cactttggag gatctttctg gacattctgt     4140

gagtgtctca tcagataagg gaagatctca gaaaactcca acttctcccc tgtcaccaag     4200

ttcccagaaa tcattgcagt ttgacgttgc aggaacttct tcagaaagat ctaagtcgtc     4260

agtaatgcct ccaactataa caggatttaa gcctaatgca cctctcactg atctgaaccc     4320

ggcagccagc agaacaacga cagagaacat ggctccaata ccaggttcta agcgcttttc     4380

tcctgctggc ctccatcatc gtatggcagc agaactcagt tatctgaacg ccattgagga     4440

gtcggtgcgc caactgtcag atgtagaaag agttagaggc atttcacttg ctcagcagga     4500

gagtgtgtct ctagctcaga taataaaggc acaacagcaa cgccatgaaa gagacttggc     4560

cctcttgaaa ctaaaggctg aacaagaggc tctggagagt cagagacaat tagaagaaac     4620

ccgaaacaaa gcagctcagg tccatgcaga atcattacag caggtggttc aatcacaacg     4680

ggaagtaact gaagtcctgc aggaagcaac gtgtaaaata gcagctcagc agtcagaaac     4740

tgctcgcctc accacagacg cagcacgtca aatctgtgag atggcagagt tgactagaac     4800

tcatatctca gatgctgtcg tggcttcagg agctcccctt gcaatactgt atgaccacca     4860

acggcagcac cttccagact ttgtgaaaca gctgaggacc agaactgaaa cagataggaa     4920

aagtccatct gtttcactct ctcagagtaa agaagggacc cttgactcaa agcatcagaa     4980

gtattctgct tcatatgata gttattctga gtcttcagga tacaagaatc atgatagaag     5040

aagtagcagt ggtagcagcc gccaagaaag tccttcagtt ccatcttgta aggaaaatga     5100

gaagaaactt aatggtgaaa agatagagag ttccattgat gaacaggttc agactgctgc     5160

agatgattct ctacgaagtg atagtgttcc atctcttcct gatgaaaaag actcaacgtc     5220

tattgcaaca gaatattctc tgaaatttga tgaatccatg acagaagatg aaatagaaga     5280

acaatcattt cgatcattac taccttcaga gagtcaccgc agatttaaca tggaaaagag     5340

aagaggtcat catgatgact ctgatgaaga agcttctcca gaaaaaacta cactgtctac     5400

tgccaaggaa ctgaacatgc cattctcagg aggacaagat agcttttcta aatttactat     5460

ggagatggtt cgacagtata tgaaagagga agaaatgagg gcagctcacc agtcttcact     5520

cctgcgtctc cgtgaaaagg ccttgaagga gaagactaag gctgaattgg cctggttaga     5580

gcatcaaaaa aaacatctac gagacaaagg agaggatgat aaaatgcccc cgctccggaa     5640

gaaacagcgt ggtttgcttt taaggttgca gcaagaaaag gcagaaataa aacgtcttca     5700

agaagccaat aaggcagctc ggaaggaaag acagctgatt cttaaacagc aggaggagat     5760

agaaaagatc cgacagacca ccataaaact acaggagaaa ttgaagtctg caggggagag     5820

taaattggac tctcatagtg atgatgatac aaaggataat aaggcaacca gtcctggtcc     5880

aactgacttg gagacccgca gtccttctcc catttcaatc tccagcagtg aaactagcag     5940

cattatgcag aaactgaaga aaatgagaag ccgcatggat gaaaagtttc tgacaaagcg     6000

ggagcaaaaa ttaatgcaac ggcgacaaca tgcagaggag ctcctagagt ggaagcgacg     6060

tttagatgca gaagaagcag aaattcgtca aatggaaaaa caagctttgg ctgcctggga     6120

caaagaatta ataaaaccca aaactcctaa gaaagaactg gaggaccaga gaacagaaca     6180

gaaagaaata gcaagtgaag aggaatctcc agtacctctg tactctcatc taaacagtga     6240

aagctccatt ccagaagaat taggcagccc tgctgttgaa tatgtaccat ccgagtctat     6300

aggacaggag cagccaggga gtccagatca cagtatactt actgaagaaa tgatttgttc     6360

acaggaacta gaatcttcta cctctcctag taaacattca cttcccaaaa gctgcacatc     6420

tgtgtcaaag caggagtcta gcaaaggaag tcataggact ggaggacaat gtcacctgcc     6480

tatcaagtcc catcagcact gttatagttg gtcagatgag tcattatcta tgacacagtc     6540

agaaactaca tctgaccaga gtgatattga aggtaggatc agagctctga aggatgagtt     6600

gcggaaaaga aaatcagttg tgaaccagct gaagaaggaa cagaaaaaaa ggcaaaagga     6660

aagactgaaa gcccaagaag ccagtctgat caagcagtta gagtcatatg atgaatttat     6720

taagaaaact gaagccgagc ttagccaaga tttggaaaca tcaccaacag ccaagcctca     6780

gattaaaacg ctctcctcag cttctgaaaa acccaagatc aaacccctca caccactaca     6840

cagatctgaa acggcaaaga attggaaatc actaacagag tcagaacgtt ccagaggatc     6900

cctggagtct attgctgaac atgttgatgc ttcactgtct ggttctgaga gatcagtatc     6960

agaaaggtct ttatctgcat atgcaaagag agtaaatgaa tgggacagtc gaacagaaga     7020

ttttcagacc ccatctccag ttctcagatc atcaaggaaa atcagagaag aatctggaga     7080

ttctctagaa aatgtacctg cattacatct tctcaaagaa ttaaatgcca ctagtagaat     7140

tcttgatatg tcagatggca aggttggaga atctagtaaa aaatcagaaa taaaagaaat     7200

agagtataca aaattgaaga agagtaagat tgaagatgcc ttttctaaag aaggtaaatc     7260

tgatgtctta ctgaaattag tcctagaaca gggagattca tctgaaattc tttcaaagaa     7320

agatcttcct ttagattctg aaaatgttca gaaagaccta gttggattag ctattgaaaa     7380

tctccataaa agtgaggaaa tgttgaaaga gagacagtca gatcaagata tgaatcatag     7440

tccaaacatc caatcaggaa aagacattca cgaacaaaag aacacaaagg aaaaagattt     7500

gtcttggtca gaacatcttt ttgctcctaa agagatacca tactctgaag attttgaagt     7560

gtcttctttc aagaaagaaa tttcagctga attgtacaaa gatgattttg aggtgtcatc     7620

tttgctgtca ctcaggaaag actctcagtc ttgcagagat aagccacagc caatgaggag     7680

ctctacaagt ggagccacta gctttggtag taatgaggaa atcagtgagt gcctaagtga     7740

gaaaagcctt tctatccata gcaatgttca ttctgacagg ctgttggaac tcaagtcccc     7800

tactgagctg atgaaaagta aggagcgcag tgatgtggag catgaacagc aagttactga     7860

atccccttcc ttggcttcag ttcctactgc agacgagtta tttgatttcc acattggtga     7920

tagggtgttg attggaaatg ttcagccagg aattcttcga ttcaaaggtg agactagttt     7980

tgctaaagga ttttgggccg gagtggagtt agataaacct gaaggaaata acaatggaac     8040

atatgatggt attgcatatt ttgagtgcaa agaaaagcat ggtatttttg ctcctcctca     8100

aaaaatatct cacattccag aaaactttga tgactatgta gacattaatg aagatgaaga     8160

ctgttactca gatgaacgat atcagtgcta taatcaagag caaaatgata cagagggtcc     8220

aaaagacaga gaaaaggatg tcagtgaata tttttatgag aaatccctac ctagtgtgaa     8280

tgatatagaa gcctcagtta atagaagtag aagccttaaa atagaaacag acaatgtaca     8340

ggacatttct ggggtacttg aagcccatgt tcaccagcag tcttcagtgg attcacagat     8400

ttcttcaaag gaaaacaaag acctcatttc tgatgccaca gaaaaggttt ccatcgctgc     8460

agaagatgac actttagaca ataccttttc cgaagaattg gagaagcaac agcagtttac     8520

agaagaggaa gacaacctat atgctgaagc ttcagaaaag ctttgtacac cacttctgga     8580

tcttttaaca agagaaaaaa accaactgga agcccagctg aagtcatcac taaatgagga     8640

aaaaaagtca aaacaacaac tggaaaaaat cagcttactg acagacagtt tactaaaagt     8700

ctttgtaaag gacacagtca atcaactaca acaaatcaaa aaaaccaggg atgagaaaat     8760

ccagcttagc aatcaggagc ttcttggtga tgaccaaaag aaagtaacac cccaagacct     8820

atcccaaaat gttgaggaac agtcgccaag tatttcaggt tgcttcttaa gttctgaatt     8880

ggaagatgaa aaagaagaga tttcctctcc agatatgtgt cccagaccgg agagcccagt     8940

atttggtgcc agtgggcagg aagaacttgc taagagactt gctgaacttg aactcagccg     9000

ggagttcctg agcgcgttag gagatgatca agactggttt gatgaagact ttggtttgag     9060

ctcttctcac aagatccaaa aaaataaggc agaagaaacc attgtacctc taatggcaga     9120

acctaaaaga gtaacccaac aaccatgtga aacattattg gcagtccccc atactgcaga     9180

agaagtagag attcttgtac ataatgcagc agaagaactt tggaaatgga aagaattagg     9240

ccacgatctt catagcatca gtattcctac aaaactgctt ggctgtgcca gtaaaggtct     9300

agatatagaa agcactagta aaagggtcta caaacaggcg gtttttgatt taacaaaaga     9360

gatttttgag gaaatatttg ctgaggatcc caacttaaat caacctgtct ggatgaagcc     9420

atgtagaatc aactctagtt atttccgacg agtgaaaaat ccaaataacc ttgatgaaat     9480

caagagcttc atagcaagtg aagtactcaa gttgttcagt cttaaaaagg agccaaacca     9540

caaaacagat tggcagaaaa tgatgaaatt tggaagaaag aaaagagacc gagtggatca     9600

tatcctggtt caggagctcc atgaggagga ggcacagtgg gtgaactatg atgaggatga     9660

gttgtgtgtg aaaatgcagc tagccgacgg gatctttgag accctgatca aagatactat     9720

tgatgttctg aatcagatca gtgaaaagca ggggagaatg ctacttgtgt gacatcttgc     9780

aaataaatcg aacgctgagt gctaatgtga gtcctgggcc tttctgcctc ctgatgtaca     9840

cccatcgcca tcatagcaag agtgcttctg gaccttgtac ttattcttaa agactaccag     9900

tatggagttc ataggacaat gtggtacacc tggtattaca gcctttgcct ttcgagacta     9960

tccactggat taatgggtta ttttcagtgg gcagggttgc acagtgtaat cctacacctt    10020

ttgctaacac ccctactagg tcccagaggg ccagaaacac ctgacttacc tctgagttta    10080

gactagggta tcacttcttt gagtctgaag tcaagtgaga gaggtataga taaatgcatc    10140

acatcacttt tgaaatgtaa ttctggtcta taccatggaa gtcataaatg gacattatag    10200

tctctaaaca gtattaaacc cttaaccact tctaaaatag gcaagctcaa taatgtctgc    10260

caacttcaca ttctggagtt tatttcattt ctttttgaag accattttct tccattattg    10320

tagttgagca gcaccaagtg gactgtcagg ctaacaggaa taagtggtag ccttgctttc    10380

tgagcaccat ctaaagaatt ttaaacctct gcattatgtt tagtgttctc tgtgtgggca    10440

tgaaaacaaa gaaatgcccc tactgaagac tgggctcaaa ggaccaatgc agggctggtt    10500

cttttacccc ttggtttact cctgcacttg tcttactcat tctgaatctc taccagctgc    10560

tcccagaatc acagatactc aggaccatct caggcatcca ggcatggcaa agtggaaata    10620

attcattttg gcctgcaaac cttcaactcc catctttccc caagaagtca gagatgctgt    10680

tacttgaatg atttaggaaa tgagtgtgtg caccaaagac aaaaagatat tgtctattgt    10740

ttgtgtgctt gttttgcgct atggaacatt ttttaattta ttttaagata aattattaag    10800

ttgaaaatgt gtgtccctat tcagaagtga aagattcatc ttgtaatagt taaacctcca    10860

tcttgaagct tctatggttc atagtctttg cacaggaacc tgtggtttta acaaaccaat    10920

acacatattg aagaagtcat tttaattcag tgaaacgaag atgggctttt ccagatcacc    10980

tgcaatagca gcagtgggat aaaatgattt aaaaacactg tacaatttaa ctctgcctct    11040

cttgcagcat tgcttctcac aactattacc tgcatctgaa aaaaaatcta tagactccag    11100

ctgctacatt agagcataag agatgctctc ctgggacctc agtaccctgc cttcttgact    11160

ggtttccgtt catcagtcct gtccctcttc aagtaatcta gaagaatgtg gatactctta    11220

ggcgtgaatg taaatgcctt aatattgaag gtcctggtta gaagcatgat acaagacatc    11280

tactggattc atatttacaa atatcctgga atgttatagc ttcaaagtat attagaaaaa    11340

ccccaaagat ggtataatct ttaagtgtgc acgttcgttt atttctgcat cttccctcca    11400

aacttgcctt tgcatcttaa atatttcact atgcacactc ccattcctct tgggtttcat    11460

cttgtcgttt aagaaatgta ctgaaataat cattggaata tttgcatttt gcacaatgac    11520

tggtatgata gctcttgaca aataaggaaa gcactgaaat gttgtgattg ggtctcggga    11580

aatgctcaga ttgatgtctt accagcattt cttctgggct tgtgatgttg agctgtagtc    11640

ttgtagccat aatgagcaaa ttgactaaga gaagcaaagg tttcttgggg ttattaacca    11700

gtagtgtgga aatactagtt ttatgtggcc aaggaaaagc aaaggctttt cttttcagtt    11760

tgtgttattt ggaagacaga aaaacatctt gtctacatcc tttggctgtt tgtaggatca    11820

cgttgtcctt acgatactga aactttacag ctgctgtaaa ttttttataa atgaatttca    11880

aaatgttata atgggactgt aggttgtttt tctacatctt cattatttgg acctaaaacc    11940

agtttttaat aagaaagttt atctttactc tttctgaaat tatgactcca gaaaaagaaa    12000

aaaaaaatac aagtcatgga atcagcaatc tggtaagaaa tgctgccaag aatgtggcag    12060

tagctgtcct gacagactcc aactgtcttt actatctgaa gaatcctagg ctccacatga    12120

gaggcagaaa tggatcagtc ttattctttt ctagaaatgg ttatctgtag tttggtagca    12180

aaaaaaaaga aaaaagaatc cataattagc agatttctta ttaactattt ggatctaatt    12240

gaaatggctt tattcttagg attaagaaag atagatgtgg atacccagcc actcgttcca    12300

tattggtatc tttttaaatc agctctgcct cttaatcaag aacctaaata ttccctcttt    12360

ctaatctttg ttccttctcc ctacaccctc atcctctttc actcttcctt cataattcct    12420

ctaagaaaaa tatctttgca tcagcagtaa tatcttttag aatagcacta tcagaattta    12480

gcagtaaacc aacatacagg cttcagattt acttctgagt ccaaaacaat ttgtgctatc    12540

cagggtagtt aactctgggt taaacaagta cagggtatag attccctctt caggtctaca    12600

caggaatttt taccataggg aaaagtgggg agagctcaaa cgtagttaat aaggaaggta    12660

atttgttttt cttttaccta aaagaaaaga aaattccttc tgtgactaca ggtctctgag    12720

aaattatctt tcaaaagaga tttcattgct cataagagtg ttgtggccta ttgataaaaa    12780

caattttgtt cagtttcttg tcttgaaaaa aaagtggcct tagctttttg caatacttga    12840

ataaagtgtg tactcgcaaa agaatttctg tagcacagca ttagagactc ataacttttc    12900

tgcaagaaat acaaacttac atcttccttt tactacctta agaatactag tgaataaaac    12960

attaattcaa agagcaaatt atagaaacta caatgacatt taatgcaaat tgtaggaatt    13020

tacatgttta caaatcatct tcaactggtt gtgcagcaat tcaataaaat atctttgtat    13080

tataaaaatg tgaagaaaaa atgtaaactg atgtaaagga ggtactgtca ttttaattaa    13140

cctatgttta atagcttttc cttctggact ttgcaaagcc ttcttggcaa acacattgca    13200

aagcattctc tgggaggttc agcctccttg tgtgtactgt actgtgcaga catgaaaaaa    13260

taaacccgtt tactgtgtgc gtgtaaatag cctggtcatc aggccatttt cagccaatag    13320

tcacatccag tgcaattttg caccgaacac ttaagggtgt ggtttgtaag tacgatctgt    13380

aaaataactg ggatgaattc ccatgtatac ctgtgtaaat agatttgtta actgaaatat    13440

actttaagaa agataaaatc tgtaaataaa ctgatttata aattaatttc a             13491


<210> 1600
<211> 3632
<212> DNA
<213> Homo sapiens

<400> 1600
acctcgcgtc ttcccaccgc gtcggaggac gtaggcgcct gggatcctgg aaggcttcgg       60

atgggaagtt tgcgttggag tccaacaccc gacaggaacc ccagttaacg cctccgcatg      120

gccaggggca gagttcttga cacctgtagc ttaatcaacg caggtggaga ttcagggctt      180

gaatcgcccg gccacgcgca agccgcaggg caccctcata ctactacttc tgccttatta      240

cccttaaaac tggagtctca gttatttgta tcccactatt ggtttttttt taaatctttt      300

ttcgtgggtt tgcccccttt tcctcagctg cgtttctgtc ttcagtcctg tagggcacaa      360

tgtctgaaca agagcgtata caggaatgtc tgcggaagga aataaggtca cttctcattt      420

ccaccaaaga tggtttgagc ccacaggagt tggagaagga gtaccttttg atggttggca      480

accatctacc actccgaatc cttgggtatc ggtccactat ggagctggta ttggacatgc      540

ctgatgttgt tcgtgtctgc cccggtgcag gtggtactgt aatactgaaa gccattccag      600

atgaatctac caaaggaata gcaagcttag ttgcaaaaca gaggagcagc cataagcttc      660

gaaactcaat gcataaggga agacctagta tttattctgg accgagatct catcggcgag      720

taccttaccg aggaagggtt gcccctattc ttccagctgt tgtgaagagt gagttgaagg      780

acctgttggc gttatctcct gttcttcttt ctgattttga aaaggcattt gccaaaagat      840

ttggacgatc attccaatac atgcaatatg gatttctctc tatgtttgaa gtgcttaatg      900

cggcttcaga tgtcatttct gtagagcaga ccagagcagg ttctttgttg atgctaaaga      960

agagtgtaac agaggaaaag ccgagaggat gtccagcagg taaaattttt acccagccat     1020

ttagaatgaa acaagggtca tactccacag gctttccggt agcaaagcca tgcttttcac     1080

aacccacttc aaacatggaa ccaccgaagc aaataatgag catggaaaag acttccaagt     1140

taaatgtagt ggagacttca agactgaatc acactgaaaa attaaaccag ctggagaaca     1200

cattcaaatc agttattgca cagattggac ctggaggaac tatcagttca gaactaaaac     1260

ataagataaa atttgttgta tctaagttcc cagagggttt gtttatttct aaactgcttg     1320

gagagtatga ggtaattttt aaagagcaac tatcaccaaa aaaattaggc ttcttaaatg     1380

tgacagaact tgttggagct cttagtgaca ttctccatgt tgagttcagg aaaggacacc     1440

aagacttact agtgtttgat gcggataaga agcctctacc acctgttcag tcagataaga     1500

aaatagaagc caaagcttgt gtctccagtc cacctagaaa ttcattgtct actgctgctg     1560

tcaaagagac tgtatggaat tgcccttcaa aaaaacaaaa agagccacaa cagaagattt     1620

gcaagaagcc taatctggtg gtaaagcctt tacagctgca agtagaaaca aacaaatcag     1680

agctcaactt ggcaatggca aatcatgaca tcccgccaga cgctgtgccg aacaagaaat     1740

tatgcagact cccaccatta gacaccagtt ccctcatagg ggtctttgtg gagtatatca     1800

tctctcctag tcaattctac atccggatct atagcaggga ttcgtcagag ttactcgaag     1860

acatgatgat tgaaatgcgg cgctgttatt ctaatcagct ggtttctgat cgatatgtca     1920

tgccagaatg ttttattcag ccgggacatc tctgttgtgt aaggatttct gaggataagt     1980

ggtggtatcg ggtcattatc catcgagtcc ttgagaaaca ggaagttgaa gtgttctacc     2040

cagactttgg aaatattgga attgttcaga agtcctccct gaggttcctc aagtgctgct     2100

acacaaagct tccagctcag gctatccctt gttctttggc ttgggtgaga ccagtagagg     2160

aacactggac atcgaaagct attttgcagt tccagaagtt gtgcggtttg aagccattag     2220

tgggggtagt ggatgaatat gtagatggaa tccttaacat ttttttgtgt gacacatcct     2280

caaacgaaga tgtctatttc catcatgtct tgagaacaga gggccatgct attgtatgcc     2340

gagaaaatat ctcttctaag ggtttcagtg agctcaaccc tttagcttta tacacgacat     2400

ccagtggagg gccagaggac attgtcttga cagaactggg ttatccttcc cagcagcact     2460

attttaatga agaccgaaag ataagtccac agtcaaaaga gagtgagtta cgtatcttgg     2520

atgagatccc cactggaatg ccatgcctgg agtcagtgac cataggtgat gatatttggg     2580

atgagaactg gttacctcta caggctaaga tgggaaaagg aggtgatgct gcctcccatc     2640

tatttactgc aagccttggt ggaaagaatc agtattcatc atgtaaagaa atgccacaga     2700

aggactggtg tttttctacc cctaaagata catgggatga ttcttggcag ccttcaggcc     2760

ttgtaaatgg aacgaaagta gaagttcata agccagaagt actgggtgct caggaaaaaa     2820

atactggcac aaacaggact caaaagcaac tagacataaa tggttcttca gattcttcca     2880

cactgcccaa attggaagaa ttctgtacct ctcttaccca gtcagagcag tcagcagacg     2940

ggagccagtc tgaacccaac aacagtcaga ctcagccaaa gcaaattcag ctttccacag     3000

cagcaccctg ttcaacaact gcagtggatg attccgcaga aaagccctct ggttctgtgg     3060

aaagctcacc agagatccta aagaatgaag atttttctag cagccgtgct attacattgt     3120

acaaagacaa gcgtcaagaa tctgtagacc agctgtcttt gattttgtct tatgagtgcc     3180

agatttctca gaagctctac attcctcgaa gtacagccac tgctgcctta ggtgctgccg     3240

cacggttagc tacatccagg agcctcctac actggtaccc cagtgtgaaa aggatggaag     3300

catgagggag ggagggagga gggagaaaaa cagaatccag ccgcttaggc tttgatgaac     3360

tcccaggcca aaatgaggag ttattgaagc aaaatagtat cttgatcatt gatacttttg     3420

tctttctgtg actatatgtt agctttatta tgctaacagt ctactttgat gtgtaagtaa     3480

gtattgatat ttactgttaa tcttgatttt tcttgatttt attctgtgtc attttgttca     3540

cctttgtttt taatgtagtt taaaggaatt tgtttttttg tgtttgtttt tcttgtacat     3600

tatcatgact gataaatgaa aattgaaaaa ct                                   3632


<210> 1601
<211> 785
<212> DNA
<213> Homo sapiens

<400> 1601
aggggctgtt gtggggagtt gaagaacacc ctggcctcct ccatcatgtc ggccaagagg       60

gcagaattga agaaaacaca tctggtaaaa gagagacatt gctggacaag caagaactac      120

aaggcagttt gcctggaatt gaagccagag ccgaccaaaa catttgatta caaagcagtt      180

aaacaagaag ggcggtttac caaagcagga gtgacacagg acctaaagaa tgaactcagg      240

gaagtgagag aagagctcaa ggagaaaatg gaggagataa aacagataaa ggatctaatg      300

gacaaggatt ttgataaact tcacgaattt gtggaaatta tgaaggaaat gcagaaagat      360

atggatgaga agatggacat tttaataaat acacagaaga actataagct tccccttaga      420

agagcaccaa aggagcagca ggaactcagg ctgatgggaa agactcacag agaaccacag      480

ctcaggccca agaaaatgga tggagccagt ggagtcaatg gagcaccctg tgctcttcac      540

aagaagacga tggcaccaca aaaaacaaaa cagggctcac tggatcccct tcatcactgt      600

gggacctgct gcgagaaatg tttgttgtgt gctctaaaga acaactacaa tcggggtata      660

tacgctgcag tgggactgct ggatctatgg tagctcaatt tttagttttt tgaggaacaa      720

cctccaaact gttctccata gtggctgtac taatttacat tcccaccaac agtgtacaaa      780

gattc                                                                  785


<210> 1602
<211> 2377
<212> DNA
<213> Homo sapiens

<400> 1602
agtggcctgg tcccaggggc tgttgtgggg agttgaagaa caccctggcc tcctccatca       60

tgtcggccaa gagggcagaa ttgaagaaaa cacatctgag caagaactac aaggcagttt      120

gcctggaatt gaagccagag ccgaccaaaa catttgatta caaagcagtt aaacaagaag      180

ggcggtttac caaagcagga gtgacacagg acctaaagaa tgaactcagg gaagtgagag      240

aagagctcaa ggagaaaatg gaggagataa aacagataaa ggatctaatg gacaaggatt      300

ttgataaact tcacgaattt gtggaaatta tgaaggaaat gcagaaagat atggatgaga      360

agatggacat tttaataaat acacagaaga actataagct tccccttaga agagcaccaa      420

aggagcagca ggaactcagg ctgatgggaa agactcacag agaaccacag ctcaggccca      480

agaaaatgga tggagccagt ggagtcaatg gagcaccctg tgctcttcac aagaagacga      540

tggcaccaca aaaaacaaaa cagggctcac tggatcccct tcatcactgt gggacctgct      600

gcgtaagtga aaccctgccc gagcccagca ctggtgccag acccctggct ccggctccct      660

ggtgacttcc ccgagcttgt gctgtatcat agtgaaggga caggtccgcc cgctgctgac      720

ttctgggtgc cgcccgagcc tgcgccctcc ctgacctgcc ttgccttcta ggcctgtgga      780

gcctccttag ctgtgaccat gcaggacttg accctggatg ggcctacccg ccagctccac      840

cctcttattc tgtccttccc tttagcaagg gcagataagg tgcctagcag gctgcccttc      900

ttggaccagg ggaaattgat ctttcttgtg ccgtttctgt cctctgcagg agaaatgttt      960

gttgtgtgct ctaaagaaca actacaatcg gggtaggtag attcatacaa gatgtgcctt     1020

ttctcgatca ggtgccttgt tgtccccaag gccatgtgct cccagccgca ttcacatcac     1080

acccctcctg aggttgtgcc aggagtaggg actgttagca gatgctgcca cccagcatgc     1140

tcagtcatac aggatgtggc accaggaagg aggacttggg tcacccagcc tagaggctgc     1200

tgcctggggc tcccatggtg gggagggtgc accactagtg gcggaactga ccttgcctca     1260

ggtcctgccc tttctcccca tccagtggga aatattcaca ccaggtctgg gcaccctttt     1320

cacccttggc ttctggagct gccttctgat ttatctgtac ctcaaccccg gtgacatcga     1380

atatgtgttt ccaacctagc gcagctgcag aacctaccag cagttccgat tcatcacctc     1440

caagctcctt aagatgcaca gtcagggctt cttgtcctgt taaataccac cccaacccca     1500

ggcctccact ggagattaaa aaccttcatt caaagccaaa ggggatgtca tggttttgag     1560

taccagtcca aaacttgagt gtgtggaggt tgattatttt tggttctata tcagtgtatt     1620

tcagactcca acccttcccc ctgcttcctg atggattggt gggaaattac atcttagtca     1680

tcttagggtc ctcccaacca ccacctccct ccattccacc tgggtctgca aacgtcccag     1740

gtcatagcat ggggagggcc cctgatgata gcggacgcca gtctgtgtgg tctcaggaga     1800

gaccctgctg cctggcccat ccgctccctc cacataatca gcctccacct gtgcatgggg     1860

ccagggtgtc ttgggtgatg cagggaaccc ctcagcctcg agttctgcct gcaccacacc     1920

cctctgaggt cttgtcacca agcaggactc aggtccctgc tgctcatagg aactgggtag     1980

ctttcttggg ttctggggat ccacccttct cacccccttg aaggtttcct ctccctccct     2040

ccacccccaa agggaacatt ccttcagagg cctcaggcct ttacaaaggt ggagaggagc     2100

cagtgaccac ccaaccttct gtgggccacg ctgtgcctgc cccaaagtcc cagactgagg     2160

gaaggtgaag cttaactgcc agcttgaaat gagagtaaag aagatacaga gcaaacagtg     2220

tttcagaaac tgtcctgccc tgggtgtgat tctttggctt caatttgaag gacgaggaat     2280

gatgggattt catattttat ttcacaccag ttcctccttg tttcatctct ttgctaagct     2340

ggctgcttct accatctaat aaataattgg ccaagtt                              2377


<210> 1603
<211> 2452
<212> DNA
<213> Homo sapiens

<400> 1603
gttgcctagg acagtggcct ggtcccaggg gctgttgtgg ggagttgaag aacaccctgg       60

cctcctccat catgtcggcc aagagggcag aattgaagaa aacacatctg agcaagaact      120

acaaggcagt ttgcctggaa ttgaagccag agccgaccaa agtaagaagc ccttttgagg      180

ccatgcaggc agccaggcct gagatccatg gggaagtgac caggagtcag gggtcatttg      240

ctgatcctag tggccaagat ttgtcccaga catttgatta caaagcagtt aaacaagaag      300

ggcggtttac caaagcagga aggacaccca gactcttgga ggagttgtct ttgctcctac      360

tgcccctgtg acttggagtc aaggccttcc atggccaccc gtgtactggt tatctccttg      420

tcatgctgca aaatgtctcc ccaactctct gcccctccct ggccctcctc ccccagtccc      480

cttagaagag caccaaagga gcagcaggaa ctcaggctga tgggaaagac tcacagagaa      540

ccacagctca ggcccaagaa aatggatgga gccagtggag tcaatggagc accctgtgct      600

cttcacaaga agacgatggc accacaaaaa acaaaacagg gctcactgga tccccttcat      660

cactgtggga cctgctgcgt aagtgaaacc ctgcccgagc ccagcactgg tgccagaccc      720

ctggctccgg ctccctggtg acttccccga gcttgtgctg tatcatagtg aagggacagg      780

tccgcccgct gctgacttct gggtgccgcc cgagcctgcg ccctccctga cctgccttgc      840

cttctaggcc tgtggagcct ccttagctgt gaccatgcag gacttgaccc tggatgggcc      900

tacccgccag ctccaccctc ttattctgtc cttcccttta gcaagggcag ataaggtgcc      960

tagcaggctg cccttcttgg accaggggaa attgatcttt cttgtgccgt ttctgtcctc     1020

tgcaggagaa atgtttgttg tgtgctctaa agaacaacta caatcggggt aggtagattc     1080

atacaagatg tgccttttct cgatcaggtg ccttgttgtc cccaaggcca tgtgctccca     1140

gccgcattca catcacaccc ctcctgaggt tgtgccagga gtagggactg ttagcagatg     1200

ctgccaccca gcatgctcag tcatacagga tgtggcacca ggaaggagga cttgggtcac     1260

ccagcctaga ggctgctgcc tggggctccc atggtgggga gggtgcacca ctagtggcgg     1320

aactgacctt gcctcaggtc ctgccctttc tccccatcca gtgggaaata ttcacaccag     1380

gtctgggcac ccttttcacc cttggcttct ggagctgcct tctgatttat ctgtacctca     1440

accccggtga catcgaatat gtgtttccaa cctagcgcag ctgcagaacc taccagcagt     1500

tccgattcat cacctccaag ctccttaaga tgcacagtca gggcttcttg tcctgttaaa     1560

taccacccca accccaggcc tccactggag attaaaaacc ttcattcaaa gccaaagggg     1620

atgtcatggt tttgagtacc agtccaaaac ttgagtgtgt ggaggttgat tatttttggt     1680

tctatatcag tgtatttcag actccaaccc ttccccctgc ttcctgatgg attggtggga     1740

aattacatct tagtcatctt agggtcctcc caaccaccac ctccctccat tccacctggg     1800

tctgcaaacg tcccaggtca tagcatgggg agggcccctg atgatagcgg acgccagtct     1860

gtgtggtctc aggagagacc ctgctgcctg gcccatccgc tccctccaca taatcagcct     1920

ccacctgtgc atggggccag ggtgtcttgg gtgatgcagg gaacccctca gcctcgagtt     1980

ctgcctgcac cacacccctc tgaggtcttg tcaccaagca ggactcaggt ccctgctgct     2040

cataggaact gggtagcttt cttgggttct ggggatccac ccttctcacc cccttgaagg     2100

tttcctctcc ctccctccac ccccaaaggg aacattcctt cagaggcctc aggcctttac     2160

aaaggtggag aggagccagt gaccacccaa ccttctgtgg gccacgctgt gcctgcccca     2220

aagtcccaga ctgagggaag gtgaagctta actgccagct tgaaatgaga gtaaagaaga     2280

tacagagcaa acagtgtttc agaaactgtc ctgccctggg tgtgattctt tggcttcaat     2340

ttgaaggacg aggaatgatg ggatttcata ttttatttca caccagttcc tccttgtttc     2400

atctctttgc taagctggct gcttctacca tctaataaat aattggccaa gt             2452


<210> 1604
<211> 802
<212> DNA
<213> Homo sapiens

<400> 1604
ctgtaagttg cctaggacag tggcctggtc ccaggggctg ttgtggggag ttgaagaaca       60

ccctggcctc ctccatcatg tcggccaaga gggcagaatt gaagaaaaca catctgagca      120

agaactacaa ggcagtttgc ctggaattga agccagagcc gaccaaaaca tttgattaca      180

aagcagttaa acaagaaggg cggtttacca aagcaggagt gacacaggac ctaaagaatg      240

aactcaggga agtgagagaa gagctcaagg agaaaatgga ggagataaaa cagataaagg      300

atctaatgga caaggatttt gataaacttc acgaatttgt ggaaattatg aaggaaatgc      360

agaaagatat ggatgagaag atggacattt taataaatac acagaagaac tataagcttc      420

cccttagaag agcaccaaag gagcagcagg aactcaggct gatgggaaag actcacagag      480

aaccacagct caggcccaag aaaatggatg gagccagtgg agtcaatgga gcaccctgtg      540

ctcttcacaa gaagacgatg gcaccacaaa aaacaaaaca gggctcactg gatccccttc      600

atcactgtgg gacctgctgc gagaaatgtt tgttgtgtgc tctaaagaac aactacaatc      660

gggcgcagct gcagaaccta ccagcagttc cgattcatca cctccaagct ccttaagatg      720

cacagtcagg gcttcttgtc ctgttaaata ccaccccaac cccaggcctc cactggagat      780

taaaaacctt cattcaaagc ca                                               802


<210> 1605
<211> 398
<212> DNA
<213> Homo sapiens

<400> 1605
gtatgagctc agagaggagc atctggacaa aatatttaaa cacagagaac tgcagcagaa       60

gctggtggat gcaaagcttg agcaggccca agaaatgatg aaggaagcgg aggagcgaca      120

caaacgagaa aaggaatatt tgctgaacca ggcagcagag tggaaacttc aggcgaaagt      180

gctgaaggag caagagacag tcctgcaggc tcaggtgagg ccaggtggac gaggcatggg      240

ggtgctgtcc tcactgtccc cagataaaaa ggctggggcc aaaggtgggc agcagaagtc      300

ctcctatgtg gcaggggatg gggggatggg aattggaaat gaagaacaac ttcacattta      360

ttcatatttt caagtaaaaa taaaagcaca atattata                              398


<210> 1606
<211> 2766
<212> DNA
<213> Homo sapiens

<400> 1606
gcgactgcgc agcgtggccc agcgcggtca aattataata cataaaagtt gtcagggcgg       60

agagcaagac attactcttc tcggattgcc ggttcgctcg cgagacttga gcgttgctag      120

gagattcggc aggcgggcgg agccagactc ggcggggcgg ggaggggtgg ggctaggctc      180

ggcgaggcga ggaagggtgg gtggagccag gcttggcggg ctgtgcgtgc tcgcggtggg      240

cggtggcggc ggctgcctcg cgaaggttcg agatccgtcg cgtgcgggag gcgggccgcg      300

atcttgcgca gggtcggtgt gggcgcaggc tgcagcgccg cgactcgtgc gggtaggcgt      360

ctgcgctcgg tttgagggct cggcgcgggg tttcctgttc ctccttctgc gcggctgcag      420

ctcgggactt cggcctgacc cagcccccat ggcttcagaa gagctacaga aagatctaga      480

agaggtaaag gtgttgctgg aaaaggctac taggaaaaga gtacgtgatg cccttacagc      540

tgaaaaatcc aagattgaga cagaaatcaa gaacaagatg caacagaaat cacagaagaa      600

agcagaactt cttgataatg aaaaaccagc tgctgtggtt gctcccatta caacgggcta      660

tacggtgaaa atcagtaatt atggatggga tcagtcagat aagtttgtga aaatctacat      720

taccttaact ggagttcatc aagttcccac tgagaatgtg caggtgcatt tcacagagag      780

gtcatttgat cttttggtaa agaatctaaa tgggaagagt tactccatga ttgtgaacaa      840

tctcttgaaa cccatctctg tggaaggcag ttcaaaaaaa gtcaagactg atacagttct      900

tatattgtgt agaaagaaag tggaaaacac aaggtgggat tacctgaccc aggttgaaaa      960

ggagtgcaaa gaaaaagaga agccctccta tgacactgaa acagatccta gtgagggatt     1020

gatgaatgtt ctaaagaaaa tttatgaaga tggagacgat gatatgaagc gaaccattaa     1080

taaagcctgg gtggaatcaa gagagaagca agccaaagga gacacggaat tttgagactt     1140

taaagtcgtt ttgggaactg tgatgtgatg tggaaatact gatgtttcca gtaagggaat     1200

attggtgagc tgcatatata aatttgacag atagctattt acatagcctt ctaagtaaag     1260

gcaatgaatt ctccatttcc tactggagga tttatttaaa taaaatatgc ttattaaaca     1320

ctcctgcaaa gatggtttta ttagtaccct ggtcattttg ttcaaggaag ggttatattg     1380

cattctcacg tgaaatataa aaagcaagtc ttgcccaata aaaacgctac attgtgtgta     1440

ttttttgttc agctaagaat tggaaaagta tttgcttgcc ttttaagtta ctgacatcag     1500

cttccaccag tgtaaaaatt gagtaaaacc tgaagttttg cataaaatgc aaatcggtgc     1560

ctgtgcttga aggttgctgt agagcatctg accccttatt accaccttaa gcaatgtata     1620

tgccatgcat taccatgcac taattcaatc acaggtgttt ctatctagat ttaaatatat     1680

ttgtcaatga atgtggaata gaaaatctaa acatgacaat aatagacata tctttgtatg     1740

gtaccagtta gttttgccgt ggatcagatg gtttataaaa gtaataacca taaagcaaaa     1800

aataatttga aagcccgtct attcctatgc tcaataaagt taagtttttc ttcattagaa     1860

cagttttatg atttatttgt ctaggagtat gtcagaaaaa tcaggctttt agtaggaatt     1920

actcctattc cccctgaagt caggaccagt gcctgtgatc tccattactt tattttcctg     1980

gaggtattag ccaacacagt tagatcagag aaagcaattg aagccaggca tgaaggctgg     2040

cgcccgtaat cccagctact aaggctggag gatcacttca gcccaggagt ttaaggctgc     2100

agtgagctat gatgatgcca ctgtactgca gcttgggtaa cagattgaga acctgtctca     2160

ttaaaaaaaa aaaaaaaaaa aaagccgtta gacacacagg aaaaatccag aagggtaaac     2220

taaactaaag ctacaattaa tatgggaatt tggaagaagt ggtaggattt aaaatacaga     2280

aacagtttat gtataggata gctataagta aatactgaaa cacattatgc ctctgtaatt     2340

ggggttgaca catgaacaga atagcagaca caatgcatat gaaagttaca gaatatggta     2400

aaagtggggt aaagatgggt ttttaatgat actaagataa ctgaaaatag gcatatagat     2460

atattccaag ccgcctgacg atctaattgt aaaaagtaaa gcatacaaat actagaagaa     2520

aatggaggaa aacgacatta tatgtgactt aaaacctaga agaaataaat aaaactattg     2580

atcaatttta actacataaa aatgtttata ggacaagaaa aaccccacca taacccaagg     2640

caaacaatgt attgacagga ttccaataat taagaatact tcatacaaaa agaaatgtaa     2700

atgaccttta acatgtaaag atgctcacct tgttcagaag agaataaacc agtgttttta     2760

cctttc                                                                2766


<210> 1607
<211> 2834
<212> DNA
<213> Homo sapiens

<400> 1607
cattttcttt gatggtaaac aggctcactt ataccgaatc caaacccagg cgagaactac       60

ggactcttga aatggtcggt gaaaggggcg aaagcaccag gaaatcgtgc ttcaacagtc      120

catgactgaa aggagggcct gaaactgtgg ccataggcgg gcccttttgt tagggccttg      180

acctgggctt ccgctacagg gcccggtcac gaggccaacg tagctccacc tctacggcgg      240

ccagtgatga cgccaccacg tcggaactgt tagaccgcgg tgacgtctcc accgcgccaa      300

actcactgaa aatcaaaccg ctaccattag gagccctcca cgcttaacat atccgttctt      360

tctcgtttga aagtaaccag gctgctcctc cccatttttc gccttcttct cgcggaggct      420

gagagactaa ccttacacaa catggcggcc tggtgtgtct ggtgtcctag agcggacgaa      480

agcaggtgac tctctagtca acttccgact tggactccga agatcgctac agaaagatct      540

agaagaggta aaggtgttgc tggaaaaggc tactaggaaa agagtacgtg atgcccttac      600

agctgaaaaa tccaagattg agacagaaat caagaacaag atgcaacaga aatcacagaa      660

gaaagcagaa cttcttgata atgaaaaacc agctgctgtg gttgctccca ttacaacggg      720

ctatacggtg aaaatcagta attatggatg ggatcagtca gataagtttg tgaaaatcta      780

cattacctta actggagttc atcaagttcc cactgagaat gtgcaggtgc atttcacaga      840

gaggtcattt gatcttttgg taaagaatct aaatgggaag agttactcca tgattgtgaa      900

caatctcttg aaacccatct ctgtggaagg cagttcaaaa aaagtcaaga ctgatacagt      960

tcttatattg tgtagaaaga aagtggaaaa cacaaggtgg gattacctga cccaggttga     1020

aaaggagtgc aaagaaaaag agaagccctc ctatgacact gaaacagatc ctagtgaggg     1080

attgatgaat gttctaaaga aaatttatga agatggagac gatgatatga agcgaaccat     1140

taataaagcc tgggtggaat caagagagaa gcaagccaaa ggagacacgg aattttgaga     1200

ctttaaagtc gttttgggaa ctgtgatgtg atgtggaaat actgatgttt ccagtaaggg     1260

aatattggtg agctgcatat ataaatttga cagatagcta tttacatagc cttctaagta     1320

aaggcaatga attctccatt tcctactgga ggatttattt aaataaaata tgcttattaa     1380

acactcctgc aaagatggtt ttattagtac cctggtcatt ttgttcaagg aagggttata     1440

ttgcattctc acgtgaaata taaaaagcaa gtcttgccca ataaaaacgc tacattgtgt     1500

gtattttttg ttcagctaag aattggaaaa gtatttgctt gccttttaag ttactgacat     1560

cagcttccac cagtgtaaaa attgagtaaa acctgaagtt ttgcataaaa tgcaaatcgg     1620

tgcctgtgct tgaaggttgc tgtagagcat ctgacccctt attaccacct taagcaatgt     1680

atatgccatg cattaccatg cactaattca atcacaggtg tttctatcta gatttaaata     1740

tatttgtcaa tgaatgtgga atagaaaatc taaacatgac aataatagac atatctttgt     1800

atggtaccag ttagttttgc cgtggatcag atggtttata aaagtaataa ccataaagca     1860

aaaaataatt tgaaagcccg tctattccta tgctcaataa agttaagttt ttcttcatta     1920

gaacagtttt atgatttatt tgtctaggag tatgtcagaa aaatcaggct tttagtagga     1980

attactccta ttccccctga agtcaggacc agtgcctgtg atctccatta ctttattttc     2040

ctggaggtat tagccaacac agttagatca gagaaagcaa ttgaagccag gcatgaaggc     2100

tggcgcccgt aatcccagct actaaggctg gaggatcact tcagcccagg agtttaaggc     2160

tgcagtgagc tatgatgatg ccactgtact gcagcttggg taacagattg agaacctgtc     2220

tcattaaaaa aaaaaaaaaa aaaaaagccg ttagacacac aggaaaaatc cagaagggta     2280

aactaaacta aagctacaat taatatggga atttggaaga agtggtagga tttaaaatac     2340

agaaacagtt tatgtatagg atagctataa gtaaatactg aaacacatta tgcctctgta     2400

attggggttg acacatgaac agaatagcag acacaatgca tatgaaagtt acagaatatg     2460

gtaaaagtgg ggtaaagatg ggtttttaat gatactaaga taactgaaaa taggcatata     2520

gatatattcc aagccgcctg acgatctaat tgtaaaaagt aaagcataca aatactagaa     2580

gaaaatggag gaaaacgaca ttatatgtga cttaaaacct agaagaaata aataaaacta     2640

ttgatcaatt ttaactacat aaaaatgttt ataggacaag aaaaacccca ccataaccca     2700

aggcaaacaa tgtattgaca ggattccaat aattaagaat acttcataca aaaagaaatg     2760

taaatgacct ttaacatgta aagatgctca ccttgttcag aagagaataa accagtgttt     2820

ttacctttca cttg                                                       2834


<210> 1608
<211> 1849
<212> DNA
<213> Homo sapiens

<400> 1608
gggcacattt ggctattttt caaagagagc atgtagttca agaaatggct tattttgttt       60

tttattcttc tttttgtggt ctatttagga aaacaaaatg aaggtggcct ttgtctttca      120

gttatggaac agctaccgga cctgcatagc catttttctg atctgaacct ggaagctcat      180

atgtatgcat cccagtggtt tctcactctt tttactgcca agttcccact ctgcatggtg      240

ttccacatca ttgacttact gctttgtgag ggtttgaaca taatctttca tgtagctttg      300

gctctcctaa agacctcaaa ggaagacctt ctgcaggctg attttgaagg tgctttaaag      360

ttctttagag ttcagcttcc aaagagatac agggcagagg aaaatgcaag aagactgatg      420

gagcaggctt gcaatattaa agtaccaacc aagaagctga agaaatatga gaaagaatat      480

cagacaatgc gagagagtca gctgcaacag gaagacccaa tggatagata caagagggag      540

aaccgaagat tacaggaggc cagcatgagg ttggaacaag agaatgatga ccttgcccat      600

gaactagtaa caagcaaaat tgctctacgg aatgacttgg atcaggcaga agacaaggca      660

gatgtgttga ataaagagct ccttttgacc aaacagaggc tggtggagac tgaagaggag      720

aagaggaagc aagaggaaga gactgcccag ctaaaagaag tcttcaggaa acagctagag      780

aaggcagaat atgaaataaa gaagactaca gctatcattg ctgagtataa acagatctgt      840

tcgcagttga gtaccaggct ggagaaacag caagcagcca gcaaggagga gctggaagtg      900

gtaaagggta agatgatggc atgcaaacac tgcagtgaca ttttcagcaa ggagggtgct      960

ttgaaactag cagccacagg cagagaggac cagggaattg aaacagatga tgagaaggac     1020

tcacttaaga agcagctgag agagatggaa ctggaactgg cacaaaccaa actgcagttg     1080

gtggaggcca agtgtaaaat tcaggaactt gaacatcaga gaggagccct tatgaatgaa     1140

atccaagctg cgaaaaactc ttggtttagc aaaaccctga actctatcaa aacggccacg     1200

ggcacccagc cattgcagcc agcaccggtc acccagccac ccaaggagag cacatagttc     1260

cagccttacc caagcacaag agcacaatgt tcaaaccaat ggaaatctgg gaggattctt     1320

cctggtgtcc ctttgaagga aagtcaagga ggccagaaaa caagccagaa tttttcagta     1380

gctctcactc tttcttgtat gacacttttc aaagggatgc tatttaaact gacctgttct     1440

atgttgaata cctattttcc agcttctgga aggccatgtt cagatccatc atagtattac     1500

acattatttt gtttgcctga tgtttagttg gaaataagta attcagaact aaatgctttt     1560

ttatttagaa ttattcataa ttatttttat cttacataaa aatggagaca tctgttattc     1620

caaggttgaa gtgataagaa gatctttgtc acaggaaaaa aaaaattgaa acctaaacat     1680

cttaagtttt caggatttat tcagataaag cacactgtgg ggccaggcat gaccactctc     1740

aggtttcctc ctgagcctga ttcccaggga agtgttaatc ctgtccaaag gaaagaacca     1800

atcagcgatc attggtttac tttcattttc tgttcggtac atctggaaa                 1849


<210> 1609
<211> 1425
<212> DNA
<213> Homo sapiens

<400> 1609
aagtatcttt gttccattga atgtttgcgg tcacagagag aacttagagt tatatgacac       60

tcaaaggaaa agcaaaagag cattaagaag tgtctgtttt tgttattgcc atttcataaa      120

tattttagta ggtgttcaat ttcattggat attctttttt tttaattgtc tttgtaccta      180

tgattgaaaa cagtagttgg tctatgactt ttgaggagag ggagaaccga agattacagg      240

aggccagcat gaggttggaa caagagaatg atgaccttgc ccatgaacta gtaacaagca      300

aaattgctct acggaatgac ttggatcagg cagaagacaa ggcagatgtg ttgaataaag      360

agctcctttt gaccaaacag aggctggtgg agactgaaga ggagaagagg aagcaagagg      420

aagagactgc ccagctaaaa gaagtcttca ggaaacagct agagaaggca gaatatgaaa      480

taaagaagac tacagctatc attgctgagt ataaacagat ctgttcgcag ttgagtacca      540

ggctggagaa acagcaagca gccagcaagg aggagctgga agtggtaaag ggtaagatga      600

tggcatgcaa acactgcagt gacattttca gcaaggaggg tgctttgaaa ctagcagcca      660

caggcagaga ggaccaggga attgaaacag atgatgagaa ggactcactt aagaagcagc      720

tgagagagat ggaactggaa ctggcacaaa ccaaactgca gttggtggag gccaagtgta      780

aaattcagga acttgaacat cagagaggag cccttatgaa tgaaatccaa gctgcgaaaa      840

actcttggtt tagcaaaacc ctgaactcta tcaaaacggc cacgggcacc cagccattgc      900

agccagcacc ggtcacccag ccacccaagg agagcacata gttccagcct tacccaagca      960

caagagcaca atgttcaaac caatggaaat ctgggaggat tcttcctggt gtccctttga     1020

aggaaagtca aggaggccag aaaacaagcc agaatttttc agtagctctc actctttctt     1080

gtatgacact tttcaaaggg atgctattta aactgacctg ttctatgttg aatacctatt     1140

ttccagcttc tggaaggcca tgttcagatc catcatagta ttacacatta ttttgtttgc     1200

ctgatgttta gttggaaata agtaattcag aactaaatgc ttttttattt agaattattc     1260

ataattattt ttatcttaca taaaaatgga gacatctgtt attccaaggt tgaagtgata     1320

agaagatctt tgtcacagga aaaaaaaaat tgaaacctaa acatcttaag ttttcaggat     1380

ttattcagat aaagcacact gtggggccag gcatgaccac tctca                     1425


<210> 1610
<211> 1988
<212> DNA
<213> Homo sapiens

<400> 1610
ggcctggacg agcgcgcttc cgacccgccg ccaccgcctc ctcccctcct tctcggcccg       60

ccccctccct cgcctcttcc tgccaggcgg cccttctccc ctcccctctc agttccctcc      120

gccctcctcg ggctccagcg gtggcggagc gaacgggacc ggcccggctt cagagcgcga      180

ggtggagggt ggaacgcggg cgcctgaagg agttgttgtc tcggcagcgc ccgcggagac      240

gtgaagaggt ggttgtggga agagaagttt gcagaactga aatggaggtc agagcttcat      300

tacagaagat agtttctaat ggtgatgaac aattggaaaa agccatggaa gagattttga      360

gagattccga gaaaaggcca agcagtcttc ttgttgattg tcaaagttcc agtgagattt      420

cagaccattc gtttggagat attccagcca gccaaacaaa taagccatct cttcagttaa      480

ttttggatcc gtctaacaca gaaatttcta cacccagacc atcttctcca ggtggactac      540

ctgaagaaga tagtgtttta tttaataaac tgacctactt aggatgtatg aaggtttctt      600

ccccacgtaa tgaagtagag gctttacggg caatggcaac catgaaatct tccagtcaat      660

acccctttcc tgttaccctg tatgtaccaa atgttccaga aggttctgtg agaattatag      720

accaatccag caatgtggag atagcatctt ttccaatcta taaggtgtta ttctgtgcac      780

gtggacatga cggaacaaca gagagcaatt gctttgcatt tacagagagt tcccatggtt      840

cggaagaatt tcagatacat gttttctcct gtgaaattaa agaggcagta agcagaattt      900

tgtacagttt ctgtacagca ttcaaacgtt cttccagaca agtgtctgat gttaaagact      960

cagttattcc tacccccgac agtgatgtgt ttaccttcag tgtctccttg gaggtaaaag     1020

aagacgatgg aaaaggaaac tttagccctg tgcctaagga tagagataaa ttttatttca     1080

aattaaagca aggaatagag aagaaggttg tgattacagt gcagcaactt tctaacaaag     1140

aattagctat tgaaagatgt tttggaatgt tattaagccc aggtcgaaac gtgaagaaca     1200

gtgacatgca tttactggat atggaatcca tgggaaagag ctatgatggg agagcttatg     1260

tcatcactgg catgtggaac cccaatgcac cagtatttct ggcacttaac gaggaaaccc     1320

caaaagataa gcaagtatac atgactgtgg cagtggatat ggtagtcaca gaggtggtgg     1380

agcctgttcg ctttctcctg gagacagtag tccgtgtgta ccctgcaaat gagcgatttt     1440

ggtatttcag cagaaagact ttcacagaga ctttcttcat gagattgaaa cagtctgagg     1500

gaaaaggcca taccaatgct ggagatgcaa tatatgaggt ggtgagtcta cagcgagagt     1560

ctgacaagga ggaaccagtc actcctacta gtggaggggg tccaatgtca ccccaggatg     1620

atgaagcaga agaggagagt gataatgaac tctcaagtgg aacaggtgat gtgtctaagg     1680

attgtcctga gaagatcctg tattcttggg gagagttgct aggaaaatgg cacagtaacc     1740

ttggtgcacg accgaaaggg ctgtctactc tggtgaagag tggtgtccct gaagcattga     1800

gggcagaggt atggcagtta ttggcaggct gccatgacaa ccaggcaatg ctggatagat     1860

accgaattct tatcacaaag gtctgttgga gtttgctgga ggtccactcc agaccctgtt     1920

tgcctgggta tcaccagtgg aagctgcaga acagcaaata ttgcagaatg gcaaatgttg     1980

ctgcctga                                                              1988


<210> 1611
<211> 2481
<212> DNA
<213> Homo sapiens

<400> 1611
atggaggtca gagcttcatt acagaaggtt agtggatcat ctgattctgt ggctacaatg       60

aacagtgaag aatttgtttt ggttcctcag tatgcagatg ataattctac aaaacatgaa      120

gaaaaacctc aactgaagat agtttctaat ggtgatgaac aattggaaaa agccatggaa      180

gagattttga gagattccga gaaaaggcca agcagtcttc ttgttgattg tcaaagttcc      240

agtgagattt cagaccattc gtttggagat attccagcca gccaaacaaa taagccatct      300

cttcagttaa ttttggatcc gtctaacaca gaaatttcta cacccagacc atcttctcca      360

ggtggactac ctgaagaaga tagtgtttta tttaataaac tgacctactt aggatgtatg      420

aaggtttctt ccccacgtaa tgaagtagag gctttacggg caatggcaac catgaaatct      480

tccagtcaat acccctttcc tgttaccctg tatgtaccaa atgttccaga aggttctgtg      540

agaattatag accaatccag caatgtggag atagcatctt ttccaatcta taaggtgtta      600

ttctgtgcac gtggacatga cggaacaaca gagagcaatt gctttgcatt tacagagagt      660

tcccatggtt cggaagaatt tcagatacat gttttctcct gtgaaattaa agaggcagta      720

agcagaattt tgtacagttt ctgtacagca ttcaaacgtt cttccagaca agtgtctgat      780

gttaaagact cagttattcc tacccccgac agtgatgtgt ttaccttcag tgtctccttg      840

gaggtaaaag aagacgatgg aaaaggaaac tttagattat tggtaattcc tattcctttt      900

gaatatttca gccctgtgcc taaggataga gataaatttt atttcaaatt aaagcaagga      960

atagagaaga aggttgtgat tacagtgcag caactttcta acaaagaatt agctattgaa     1020

agatgttttg gaatgttatt aagcccaggt cgaaacgtga agaacagtga catgcattta     1080

ctggatatgg aatccatggg aaagagctat gatgggagag cttatgtcat cactggcatg     1140

tggaacccca atgcaccagt atttctggca cttaacgagg aaaccccaaa agataagcaa     1200

gtatacatga ctgtggcagt ggatatggta gtcacagagg tggtggagcc tgttcgcttt     1260

ctcctggaga cagtagtccg tgtgtaccct gcaaatgagc gattttggta tttcagcaga     1320

aagactttca cagagacttt cttcatgaga ttgaaacagt ctgagggaaa aggccatacc     1380

aatgctggag atgcaatata tgaggtggtg agtctacagc gagagtctga caaggaggaa     1440

ccagtcactc ctactagtgg agggggtcca atgtcacccc aggatgatga agcagaagag     1500

gagagtgata atgaactctc aagtggaaca ggtgatgtgt ctaaggattg tcctgagaag     1560

atcctgtatt cttggggaga gttgctagga aaatggcaca gtaaccttgg tgcacgaccg     1620

aaagggctgt ctactctggt gaagagtggt gtccctgaag cattgagggc agaggtatgg     1680

cagttattgg caggctgcca tgacaaccag gcaatgctgg atagataccg aattcttatc     1740

acaaaggact cagcccagga gagtgttatt actcgagata ttcatcgtac atttcccgca     1800

catgattact ttaaagatac tggaggagat ggtcaagaat cgctctataa gatctgcaag     1860

gcctactctg tgtatgatga agacattggg tactgtcaag ggcagtcttt tcttgctgct     1920

gtattactgc tgcatatgcc agaggaacaa gcattctgtg ttttggtgaa aatcatgtac     1980

gactatggtt tgagagacct ctacagaaac aacttcgaag atcttcattg caaattctac     2040

cagttggaga gactaatgca ggaacagcta ccggacctgc atagccattt ttctgatctg     2100

aacctggaag ctcatatgta tgcatcccag tggtttctca ctctttttac tgccaagttc     2160

ccactctgca tggtgttcca catcattgac ttactgcttt gtgagggttt gaacataatc     2220

tttcatgtag ctttggctct cctaaagacc tcaaaggaag accttctgca ggctgatttt     2280

gaaggtgctt taaagttctt tagagttcag cttccaaaga gatacagggc agaggaaaat     2340

gcaagaagac tgatggagca ggcttgcaat attaaagtac caaccaagaa gctgaagaaa     2400

tatgagaaag aatatcagac aatgcgagag agtcagctgc aacaggaaga cccaatggat     2460

agatacaagt ttttttttct t                                               2481


<210> 1612
<211> 7613
<212> DNA
<213> Homo sapiens

<400> 1612
agccaagcgg cgggctggcg gcgggctccg acgtctgcgc caggacctgg ctggctgagc       60

ccggcgcagc agcagcagcc agggcagcgc ggcccctact ccctgtcagg tcgtagaggc      120

gagcagggac cagctggtcg ccggcccctc gggcaagatg gggaaccggg agatggagga      180

gctgatcccg ctggtgaacc gtctgcagga cgcgttttcg gcgctgggac agagctgcct      240

gctggagctg ccgcagatcg ccgtggtggg cggccagagc gccggcaaga gctcggtgct      300

cgagaacttc gtgggcaggg actttctccc tcgagggtcg ggcattgtaa caagacgacc      360

tcttgtgctg cagcttgtta cttctaaagc agaatatgcc gagtttctac attgcaaagg      420

aaagaaattt acagattttg atgaagttcg ccttgagatt gaagcagaaa cagatcgcgt      480

gactggaatg aataaaggca tttcctccat acccattaat ttacgagtct attccccaca      540

cgtgttaaat ctaaccctta ttgatctacc tggaataact aaagtgcctg tgggagatca      600

gccaccagat atcgagtatc agatcagaga aatgattatg cagttcatca cgagggagaa      660

ctgtctgatt ttagctgtta ctccagccaa cactgatctt gcaaactcag atgcgctgaa      720

gctagctaaa gaagttgatc ctcaaggtct gagaaccatt ggagttatca ccaaactgga      780

ccttatggat gaaggaacgg atgccaggga tgttctagag aacaaactgt tgcctcttcg      840

caggggttac gtgggggtgg taaacagaag ccagaaggac atagatggga agaaggacat      900

aaaggcagcc atgctggcag agaggaagtt tttcctttcc cacccggctt acagacatat      960

cgctgaccga atgggaaccc cacacctgca gaaggtcctt aatcagcaac ttaccaacca     1020

cattcgggat accctaccaa acttcaggaa caaactacag ggacagttgc tctccataga     1080

acatgaagta gaagcctaca aaaatttcaa accagaagac ccaacaagga agaccaaagc     1140

attgctgcag atggttcagc aatttgctgt ggactttgag aagagaattg aagggtcagg     1200

ggatcaagta gataccctgg aactctcagg tggtgctaaa atcaatcgta tttttcatga     1260

acgctttcct tttgagatag taaagatgga gttcaatgag aaagaattgc gaagagaaat     1320

aagctatgca atcaaaaaca tacatggtat caggacaggg ttgtttactc cagacatggc     1380

atttgaagcg atagtcaaga aacagattgt aaagttgaaa gggccttcct tgaagagtgt     1440

ggatctggta atacaagaat taatcaacac tgtgaagaag tgtaccaaaa aactggcaaa     1500

cttccccaga ctctgcgagg aaacggaaag gattgttgct aaccacattc gtgagcgaga     1560

agggaagaca aaggaccagg tattgctatt gattgacatt caagtctctt acatcaacac     1620

caaccatgaa gacttcattg gcttcgcaaa tgctcagcag aggagcagtc aggttcacaa     1680

gaaaaccaca gttggaaatc aggtgattcg caaggggtgg ctcaccatca gcaacattgg     1740

catcatgaaa ggcggctcga agggatactg gttcgtcctt actgcggaaa gcttgtcctg     1800

gtataaagat gatgaggaaa aagaaaagaa gtacatgctt cccttggaca acctgaaagt     1860

tcgggatgtg gaaaagagct ttatgtctag caagcacatc tttgcactct ttaatacaga     1920

gcaaaggaat gtatacaaag actatcgctt ccttgagctg gcatgtgatt cccaggagga     1980

tgtcgacagc tggaaggcat ctctactaag agctggggtc tatcctgaca aatctgtagc     2040

tgaaaatgat gagaatggac aagcagaaaa cttttccatg gacccacaat tggagaggca     2100

agtggagacc attcgcaacc tcgtagactc ctacatgtcc attatcaaca aatgtatccg     2160

agatctaatt ccaaaaacaa taatgcacct tatgatcaat aacgttaaag atttcataaa     2220

ttccgagctc ctagcacagt tgtattcttc agaggaccaa aataccctga tggaggaatc     2280

tgctgagcag gctcagcgcc gggatgagat gcttcgaatg tatcaagcac tgaaagaagc     2340

ccttgggata attggggaca tcagcacagc caccgtgtcc actccggcac cccctccagt     2400

ggatgactcc tggatacagc actctcgcag gtcacctcct ccaagcccca caacccaaag     2460

gaggccaaca ctaagtgctc ccctcgcaag gcccacatcc ggccgaggac cagctcctgc     2520

cattccctct cctggccccc actctggggc tcctccagtc ccattccgtc caggcccatt     2580

acctcctttc cccagcagca gtgactcctt cggagcccct ccacaagttc catctaggcc     2640

tacgagggcc ccgcccagtg tcccaagccg gagaccaccc ccatcaccaa ctcgtcccac     2700

tataatccgc ccactagaat cctccctgtt agactaaacg aagtgtctgg catggcaatt     2760

aatcactaat gaattatgcg aaagcaacat atttgataac cgttgcagta aatcatgagt     2820

agtcgcatgt gtggacatca gtaggcaagt aaccagtttt actaatgcat tcatcgctca     2880

tcttcattgc tcatggtatg tcaaaccttt ggggtttgac tcagaaactg ctaacctttt     2940

agaggcttta tatgttgtac tgaccaaggt aggtttgtat agcagcccta tactttgggg     3000

atcatttgcc taccatggca tatatttgaa attgctttgg acaagttttc taggctatct     3060

accaggtagc tcattaaacg taattcttca gatatgagat agtgggctta gacctaagcc     3120

atacatattt cttttcccac attctgttta ggatgacagt aattctgttg tctaccatta     3180

atgctactac ctactccata attgcctatt tagctcctct tttcttcctt tttatttcat     3240

aagactgcta ggaagtgatt ttttaaaatt aggactcctt aagaataaac ttttccagaa     3300

gcacgaggta gtttgcaaag gaaaagtctg cactgtttgc tctaaagagc ttctcctcat     3360

tccaatgtgt tttgcttcat gctagaagca tatgcaacag tgaataaaag cttctttttt     3420

tgttaatcag tcaataaatt tggctaatta gtttcagagt tcaaggaaga agcaaaatat     3480

cacatctcta gaagtgttgg gaaaaatata atttctttct ttacttatat tcacctcatg     3540

gtaggttata ttgaaggctg acatggagaa tgtttacttt tctatttggc atagctaact     3600

acactttgat actaactcca gttttactat tattattttg gttggaaaaa aaattcactc     3660

tttacgtgct aatttgtaat cttgttttgt aagaatttat cctacccttg aaacaggctc     3720

agtgtaactg tatatccatt ctaggctttc ttaataaatc ttgaggctat gggataatca     3780

catttaaaga atggttcctg aaatgaagtc agtagaaatg gcatgggata agagcagagc     3840

tcacactttt acagttgcag tatttcaaag tccctatcca ggtcactcca gaaaagggta     3900

ttgaaacgtt gaaatctaaa gcaaatttgc aatttcttaa gatttctaaa atttaccaga     3960

acagtttagc ctgggggtta atagttaagt cttgaggcta agttttggac taccaaggac     4020

cagatgattc acatgtagga aacagccaga agccaactgg aattttgtgt gctaactgtt     4080

cccagacagc agagcaagta ttcactgagt aggggtgtcc catgacacta tttcatattc     4140

tacagaagta aatcaggttt caccaactga aatgtctccc tttgaaagta gcaaacatga     4200

tttgtatgtt aacttaactt taatttcctg tgtagtttac acccagagca gatactcata     4260

aagtataaag taaaaacttt taaccattat taaacagaga acttgccatg ttgagtgcca     4320

ttgtattgaa cttattctaa aggcttatgc taacccattt ataattggta aaaatcagaa     4380

aatacaagat ttacataaag gtcatttcaa cttttaaggt taccagtgat tgtataaaaa     4440

catcacaatc ctaaatcctc tcgtatctca ccccaaaccc caaactgggg gaaaaaaagt     4500

taactctttg tgaatggaac caatgtgcaa gatacatact gcatttttaa aatagtgtct     4560

cagctaaatg gaaaactgtt aagcaaacat ccatagtaaa acaaataatc ttcagtgaga     4620

tctttttata aaacttcttg tttttaggat tccctttgct tcttcctttg aattctctaa     4680

aataggcagc taacggatta tatacttcag ggtttggctt tgtgctaaat gtggttttgt     4740

gttttgctgt atttcaaaat tttccttctg ttaaaggaaa atattgtgaa taaccactgg     4800

tgtgttctta gatcagcaca aaccatgtca aaaaaaattg gagatttttt tccaattttc     4860

cttccactga tcttaggcag taataaacaa tggcatttgt catctttggc acttgctttt     4920

agattatagt cccacagttg cactgcccca attgtctacc tttgtgggta catttttgtt     4980

ctttactcct aagttatttc tcatagaacc cagcctactc tagaatttca gcagtgacat     5040

tggagaatat ttttaatttg ctgcagtact atgtcatatt attagtatga atctcatttc     5100

ccaaagggtt tgtattctgc taaaaggaga tgccaatgtt gaatgaagtc tgaaactcta     5160

gtatgtgcat agtttgacgt gcagcatgca caccaggcct taagatggga atgtagctta     5220

atgattttct gtttcccata ccatttctaa tcttttgtgt aattttctct taactgattg     5280

ctctgatatt gtaaacacaa tagatgtagc tctatcatgt ctagcataat ttaaaaaatc     5340

agtgttttta ggatttggga aaataaactg taaatgttta tttgataggt aaatatagtt     5400

ttattgtcac atgctaaata ttgcatgcat attgactaat tggaataacc atttactcaa     5460

ttatggacag cttattgaaa tagtattgat ttagaaaaag tatattgcat ttctaaaaaa     5520

catctaccaa ggttactcgt ctgaatattg cttttagccg tgttttataa catagacgag     5580

cagtagggtc tgtttattag caaatttcct atttgttcca atacaaactc actttattct     5640

aaagtatatt aatgaaacca gttcctgtga tgtaactgta agccttctcg acttagactt     5700

aaaaagtggt cacatagatt aattttgtga ctttttagta tagactgtag ccataattct     5760

caaatatgaa atgggaccta ataccagtat gtgataaatg ttgatgtttt ctgtgtacaa     5820

acacattttc tatgcatgtg tctctgtgta tatggcatat acctagtaag tatgtttctg     5880

taagtatgtg tattttatgt ccatttgagt aggtaggtag gttttaaaaa tactagttaa     5940

aatgccacaa gcatgagtgt gattgtatgt gcactgtgtg tatatatata aatatatgta     6000

tatgtatggt tgtaaatatc tatgtataca tgtacttagt atgtgtggta tcaggatatt     6060

ttttaaactg tgataataca acagatagct ttgaatgatc tgccataaca tgtggtaaca     6120

atagttcatt tctcataaca tatatgaggt atacaaaatt ttctaactcc agattgtagt     6180

cattttgaga ggtacaaagc tcataattac catgacaaca tggtaatgtc catagacatt     6240

tgtatctgaa tccacaagaa gatctgaatc taagaaggaa ttacctttga caatattttt     6300

cggtaagaag taaaacctct ggagacctat ctttaagatc tctaattgga attataaatt     6360

atttttggat tgctgagctg aatcttaaaa agccaagttg atatacatag tcatttttcc     6420

tctatggtag aagtaaaaaa aaaaaaaaag gacatagcaa cattaaagta gtggattttt     6480

ctgagtaaat ttgctgaaaa tataagagag aagctatcta ataccttgga ggtaggtcat     6540

ccactttttc aggtaaacat ttttcatttg gcaaatggca taattatttg aaagtgacag     6600

gaatctcctc agaatgaaga ataaagccta ctaggtctct aactgttgaa ctcatgaaag     6660

aagatagtgt atgagactta agccatgagt tttgtatcat ttcaattaga agactactag     6720

ctgtgagctc agagtttaat gtaaatgaat ctagatgatt ttgaagaaat gattattcgt     6780

tcaccagatc actcattgta cattctaaaa agctcaaatg agtcttctag atactcttac     6840

tcatcctgtc tggttgctat gtttaaaatt atgtggtgct gtgtaggtga aactttaaga     6900

atatttttga agcatatgta atatatgcac tgctatttgt gtgtgtgtgt gtgtctttgt     6960

atatatgtaa gaatgtgtgt atgtgtgaga gcaagagaga ggaaactcaa agaggagtgt     7020

ttgtcttaag acctgttcat actggtatat tggtgagact tctcacttct ggttggaggt     7080

ttcacatatg gctcaactca agtcattaat ctctttttaa tttttactct tgaattcctt     7140

aaacttcgct cattatgaaa tgttttaaaa ttatgacaaa aattactctg tctaaccact     7200

tgccttgtct gctaccagtt tgttaaaaat tattcccccc aaccagtaat tccaccagta     7260

ctacttgatt tgtgttatat ttcctatgta catgtacagc ctttgttttg cttgcttgtc     7320

tatttttact ttcccttttt tgggtcaaat ttttcttttg ctttgtttga agaaggaata     7380

tacagaagta aaatcttgtc ttctctgctg attctttaat taatatgagc cggatacttt     7440

ccactgtctt cttggcactt tcaggatttc ttaatgctga tatatggact cttagaatgg     7500

aatttttgaa gaaaaatctc aaagcctgta tcgttcttga aggtcacatg tacctattgt     7560

gaaaatgtga agctgtattt ctgaagctga aataaattat aacatttgaa gga            7613


<210> 1613
<211> 5492
<212> DNA
<213> Homo sapiens

<400> 1613
agtgaatcgc tctcgtcggc agtgtttgtg gagggcctga agagacaggg aggttgtgcc       60

aggctggagg aggcttgtct ttccgaagct ggagaggatc ttacgggggt tcgcttttcc      120

ctgcctggga agaatttccc ctgtggtagc agcagcagca gcagcagaag cagaaacagc      180

agcagcagca acagcagcag cagcagcagc accaccacca ccactacctc ctcttctggg      240

gcacaagaca gaatgcctgt gctagagcga tatttccacc cagcagagct aggcaggagg      300

tggacaggcc cagaaggtgt gctgccctcc tccccgggaa gccggccggg gtgccagcag      360

gggccgctgc cctgggactt gccagagatg atcaggatgg taaagctggt ttggaaatcc      420

aaaagtgagc tgcaggcgac caaacagaga ggcattctgg acaatgaaga tgctctccgc      480

agctttccag gagatatacg actaaggggt cagacggggg ttcgtgctga acgccgtggc      540

tcctacccat tcattgactt ccgcctactt aacagtacaa catactcagg ggagattggc      600

accaagaaaa aggtgaaaag actattaagc tttcaaagat acttccatgc atcaaggctg      660

cttcgtggaa ttataccaca agcccctctg cacctgctgg atgaagacta ccttggacaa      720

gcaaggcata tgctctccaa agtgggaatg tgggattttg acattttctt gtttgatcgc      780

ttgacaaatg gaaacagcct ggtaacactg ttgtgccacc tcttcaatac ccatggactc      840

attcaccatt tcaagttaga tatggtgacc ttacaccgat ttttagtcat ggttcaagaa      900

gattaccaca gccaaaaccc gtatcacaat gctgttcacg cagccgacgt cacccaggcc      960

atgcactgct acctgaaaga gccaaagctt gccagcttcc tcacgcctct ggacatcatg     1020

cttggactgc tggctgcagc agcacacgat gtggaccacc caggggtgaa ccagccattt     1080

ttgataaaaa ctaaccacca tcttgcaaac ctatatcaga atatgtctgt gctggagaat     1140

catcactggc gatctacaat tggcatgctt cgagaatcaa ggcttcttgc tcatttgcca     1200

aaggaaatga cacaggatat tgaacagcag ctgggctcct tgatcttggc aacagacatc     1260

aacaggcaga atgaattttt gaccagattg aaagctcacc tccacaataa agacttaaga     1320

ctggaggatg cacaggacag gcactttatg cttcagatcg ccttgaagtg tgctgacatt     1380

tgcaatcctt gtagaatctg ggagatgagc aagcagtgga gtgaaagggt ctgtgaagaa     1440

ttctacaggc aaggtgaact tgaacagaaa tttgaactgg aaatcagtcc tctttgtaat     1500

caacagaaag attccatccc tagtatacaa attggtttca tgagctacat cgtggagccg     1560

ctcttccggg aatgggccca tttcacgggt aacagcaccc tgtcggagaa catgctgggc     1620

cacctcgcac acaacaaggc ccagtggaag agcctgttgc ccaggcagca cagaagcagg     1680

ggcagcagtg gcagcgggcc tgaccacgac cacgcaggcc aagggactga gagcgaggag     1740

caggaaggcg acagccccta ggggccggcc caacttagac gcggctctcc tccggcaggg     1800

cccccagagg gcagaagcag cgtggagggg ccctcacgca gcagcccagc cactttctga     1860

gtgttgtcct ggggctcttt ggaacgccat cttcctccca cttacctgcc tcccctcctt     1920

ttcgcaaatg tacagaagcc atttgtcacc tcagcattcg ctgccgaaat gagcaactcc     1980

attcagtaac gtgggagctg atcccacggg caggctctcc ctgctccagg agaagactag     2040

gaggaagaat gaggtgctcc tgccgtgtcc gccttgttcc gggtcgcact ggaacaggca     2100

gcaattccta agtccggagc gtttgagcgt ttgctatctg actgctgatc tgcgtgacag     2160

aaacaccagc atatttgcaa cgccaaggat attggtctta agtgcaagag cacaaatgag     2220

agtgtgagag aaagtacctt ctattttaat aataatatta ttataaaaat aataaatctt     2280

tttaactttt atattttatg cactagacaa tggatctgca actttggact aaggtcattc     2340

aatgtaccca aacttgaaca gggggttcat tgttttgcta ttgactttat tatgccactt     2400

tggggcagag acttggcatc ttcgcagttt aagaaaccac gtttcctatc caatccgaag     2460

ggaaggtgct gtacagttca ttcctttgca ccattagcca atctgtcttt tatggattct     2520

gtgacatgtt tatattcacc catgtacatt ttctgtaaat accaaacgct actgattccc     2580

atgccaaaat acatgagtat tatgggattg ctacctgtat aaacaatggc actgtgaaaa     2640

tactgttagt tttaatacaa gagaatgcat ttgtaaatat ggtatagagt ttattaatat     2700

actattgttt gcagataaag gccttaactt taaacatctt tcatcttctg aaagctgccc     2760

aacttaaatc ctcatagatg tctttctcaa ctgccttccc atgttcatct gtatgttttc     2820

cagctaaggt cacaaaccaa aactgaataa agtctttgag gaaacatttt ggaaacttca     2880

catgcattcc gcttgagacc atagtgttta atctatggca ccaagcatcg tttcctcaga     2940

ttaatgagac ccttcaacaa gcctgaatca gtcacttttc aacacagcga tgttttaaca     3000

agccagctgc taagcttgtg tttatgtgac tcttgttaca gatcatggcg gtgcgtcagc     3060

ctcacaggag acatagcagg tctcagaaac cttctatgac cctgtcatct aaccatcagg     3120

gaattccctg ctcccatgcc acacatttgt ctattatggc tatagtacca aagtactttt     3180

ggtgtttggt tggtgtgcat ttctttagtg tcgatagtaa ctggattttt ctttttcctt     3240

aatctcatgt gaacaactac ccaactgttt agctgaagtt catattattt aagtaaagaa     3300

aatatttcag ttttataaca gactttacct tcctggcagg tcattgtagt taattatgtc     3360

tctagcttgg agtgtcacct tggaatttcg ttgccatttt ttctcagaca cctggccgta     3420

aaatcagttt gttacagcat tcttctctag gctgctaaac gctgtgcatt gaaccttttc     3480

tttagaagtt tcagcgtaac taatgttaga tgaaaattgt tgatgcccct ttctttttac     3540

tttaaacaat gtggtagtgg gagaatgact gtttctgcca ctatcaacct gatcctcatg     3600

ctgatagaat gacagctagc acttatttcc taagtgcaac tgttttagag atttttctcc     3660

taacatgcaa aggaaatact gattggccta taataagttc ctatagggag actgaggctt     3720

gcagaattaa ggttcagggg aaattttgga aagttggttg tattttcatt gaagtaggag     3780

agattatcag atggtgctaa agaaagtgtg aagatcttat gaaataggtg gatggtaagt     3840

tgaaattatt gatgtgggta agaagggagg ttgtggaaag ttaacactag ctttgtattt     3900

ttttttctgt aaaactgtga actgatatat tttcctttat cactttagta ttctgcagtt     3960

ctcagcttgg tgaggctcca aaagagaata tgtcagatgt attcctactt ccaaacctgt     4020

cttactttgg tttgatggta cacatagggc ttttgaacag tctattttta atgtatatga     4080

ggtcaaatca aggaaggcaa ttgctgggga caagaaaagt agaggtagga aagaagacac     4140

tattttagct aatggggttt cttgggacta aaaaatggct ttgtttaaat tataattata     4200

taataattta aataaatgag attggaggta ttcttagtag ttctgagttg atagtttaca     4260

ttacaattag gtcttgaaga agagctcaca gagaaaaaac taccaaatat ccaatgggta     4320

agcccatgat gtagccacta gtacaataaa aatctgaagt aaaatgaggc ataaacttga     4380

tgcagctgcc tccctcattc aactggggag ttcttgagtt cctcatttgt tggtaaaaag     4440

aaaaagaatg tgaaaatgtc tctttttttc ttggctatta gtggctgtct tgcaatattt     4500

caataggagt ccaattacta gttaaaacac tggcggggtg cggtggctca cgcctgtaat     4560

cctagcactt tgggaggcca agttgggcag atcacaagtt caagagatcg agaccattct     4620

ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aattagctgg gcatggcagt     4680

gcgtgcctgc aatcccagct actcaggaag ctgaggcagg agaatcgctt gaacctggga     4740

ggtggaagtt gtagtgaact gagatcgcac cactgcactc cagcctggca acagagctag     4800

aatccgtctc aaacaaacaa acaaaaaatc ccacagctat tggatcatcc acagattttt     4860

tctttacaat cttgttctcc ttgtccatgg accatcaata gttgacttgc caggtttaat     4920

tctttcattg cttgagaaga aaggaatcaa aggactgtgt gtagtaagct gacggtaaag     4980

ttaagattaa attaagacag agagagaata catatcactg ccaggcctga taggaaaaat     5040

ctgctcttcc ttttaataac agtgatgaat tgtcaggacc ttatttagga aaccctgacc     5100

tacccataac tccctgctag gctaagtaga aaccaggtta tttctccctg cttatggctc     5160

cccgcaaagg gacttgcagc gtgtcctgca actttgtctt cagatagtgc ttcctacaaa     5220

actaggtctt gttttgtaat cttttctcgt gttgaatcag atctgcttac ttatttaggt     5280

ttggttatga gcttgtatct cactgtattt ctcatgcttt gttcttttaa acaaatcctt     5340

taaactgtgt cattttgtat acacatgtga ggtttgaaaa aaaaaaaaaa aaaaaaaaga     5400

actaccttgt gagttttgct caaaatgtgg cctaagtagc cattggcatg tctagatgaa     5460

caaataaaaa taaagataat ttctttaaaa ta                                   5492


<210> 1614
<211> 1295
<212> DNA
<213> Homo sapiens

<400> 1614
ttgtttaaca gctggcccgg aagtttaagt gaatatgcgg cttgggctcc aaaagttgct       60

gtacggtatt ttattttaaa gtagaaatct gtccgctttt cacttacgga ggccttacag      120

tgtgtgttct gtgttacttg agtttatacg cactgcagaa tttgtttacc ctgctctttt      180

ggaaacgtat tccggaagcg aaaccctgag taatcggaag tggttaggag tgagagagct      240

gctggatatg cggagggact gggcgggtcg gcttccgaat ggaagaggtc tgtgagaagt      300

taacctggtg ataccgatcc gaagagccta tcaagtgaag ccccctgaaa tacggagaat      360

aagaatctta gaggttgttc agcagaagtc ttggagtgca ttttcagtgg ttaaggtgaa      420

aaaatgacta ctaaaaattt agaaaccaaa gtcaccgtta cttcatcccc aatccgagga      480

gcaggagatg gaatggaaac tgaggaacca cctaaatctg ttgaagttac ctccggagtc      540

caatctagaa agcatcatag tcttcagagt ccatggaaga aagcagttcc atcagagagc      600

ccaggagttc ttcagctagg gaaaatgctc actgaaaaag caatggaagt taaagctgta      660

agaatattag ttcccaaagc tgctataact catgatatcc ccaacaaaaa tacaaaggtt      720

aagtctctgg gacatcataa aggagaattc cttggtcagt cagagggagt tatagaacct      780

aataaggaac tctcagaggt aaagaatgta ttggaaaagc tcaagaattc tgaaagaagg      840

ttactacagg acaaagaagg tctttcaaac cagctccgtg tacagacaga ggtaagaaga      900

gccttaatcg ataaaatgag tactactctt tacgtctgga ccttttaaac gtgcatgtta      960

gaaaactaca tttctttatg ggaatgtcat tcatcctagc ttgtcagttc tctaaaatgc     1020

ttcctcttaa atttctcatt ctttctcagt tctctaggga tactttatat tgggaactta     1080

tactctaaac ctcattgaag atggaggtgt gaggtgcttt ggacaagacc accaataagt     1140

tgtaaaagta ggttacaatt ataaactgcc agaccaaaga ttgaccaagt caggcatagt     1200

aattgaccag cagtccttgt tttaaggatc cgtaaattcc aagtagtttt gcttgtgtat     1260

acgggatact tggaataaag agaatggcga tataa                                1295


<210> 1615
<211> 2749
<212> DNA
<213> Homo sapiens

<400> 1615
ttgtttaaca gctggcccgg aagtttaagt gaatatgcgg cttgggctcc aaaagttgct       60

gtacggtatt ttattttaaa gtagaaatct gtccgctttt cacttacgga ggccttacag      120

tgtgtgttct gtgttacttg agtttatacg cactgcagaa tttgtttacc ctgctctttt      180

ggaaacgtat tccggaagcg aaaccctgag taatcggaag tggttaggag tgagagagct      240

gctggatatg cggagggact gggcgggtcg gcttccgaat ggaagaggtc tgtgagaagt      300

taacctggtg ataccgatcc gaagagccta tcaagtgaag ccccctgaaa tacggagaat      360

aagaatctta gaggttgttc agcagaagtc ttggagtgca ttttcagtgg ttaaggtgaa      420

aaaatgacta ctaaaaattt agaaaccaaa gtcaccgtta cttcatcccc aatccgagga      480

gcaggagatg gaatggaaac tgaggaacca cctaaatctg ttgaagttac ctccggagtc      540

caatctagaa agcatcatag tcttcagagt ccatggaaga aagcagttcc atcagagagc      600

ccaggagttc ttcagctagg gaaaatgctc actgaaaaag caatggaagt taaagctgta      660

agaatattag ttcccaaagc tgctataact catgatatcc ccaacaaaaa tacaaaggtt      720

aagtctctgg gacatcataa aggagaattc cttggtcagt cagagggagt tatagaacct      780

aataaggaac tctcagaggt aaagaatgta ttggaaaagc tcaagaattc tgaaagaagg      840

ttactacagg acaaagaagg tctttcaaac cagctccgtg tacagacaga ggtaaatcgt      900

gagttaaaaa agttactggt ggcttctgtt ggggatgatc ttcagtatca ctttgaacgt      960

ctagcccgtg agaaaaatca gcttatttta gaaaatgaag ccctaggtcg aaacacagct     1020

cagctttctg aacagttaga acgtatgtca atacagtgtg atgtatggcg aagtaaattc     1080

cttgcaagca gggtaatggc agatgagtta accaactcaa gagcagcttt acagcgtcaa     1140

aaccgtgatg cacacggggc tatacaagat ctcctaagtg aacgggaaca gtttcgtcaa     1200

gaaatgatag ctacccagaa attattggag gagctcttag tttccttgca atggggaaga     1260

gagcaaactt actcccctag tgtacaaccc cacagcacag cagagctagc attaacaaat     1320

cacaagttgg caaaagcagt aaattctcat cttctgggaa atgttggcat taacaatcaa     1380

aaaaagattc catcaacagt tgaattctgc agcaccccag ctgagaaaat ggctgaaacg     1440

gttctaagaa ttttagatcc agttacctgc aaagagagtt cacctgataa tccatttttt     1500

gagtcttcac caaccacctt acttgctaca aagaaaaata ttggacgatt tcatccctat     1560

actagatatg aaaatataac tttcaattgc tgcaatcact gccggggaga actgattgcc     1620

ctttaacagt caatatgttg gaggcatgct aaggtacttc cttattaccc aagagtcatt     1680

attatttggg agctggggtt cttacaatgc tagaaataat atcacttcct atttacataa     1740

tgtatacacc caaagatatt ttatgtacta gactccagat taccctttct taataaatat     1800

ctcagggtaa ggaaagaaag aaactgtata gatatattta aaatagagaa tactttccaa     1860

gcaatacatg atacttttcc taaaagactc taaaagaaaa agattctgta actctctttt     1920

agcaccaaat tattgtttat cttgctggat attttatatg aacagtgtta atttagatgc     1980

actaaagcaa aggtaggcaa actacaacca tgagtcaaac atggccacac ccattcatgt     2040

gctattgtct aagctggttt tgcactacaa ctgcagagtt gaatagatgc agcagatcct     2100

ttacagaaaa agttttctga cctcaattct aaagtaattg tagtagggag ctggaggact     2160

ttctttccct ttatggtaat tttttgagct acaaaagagc cttgcagaaa tgggtgaagg     2220

gattaatctt ttaaaaataa atgctatata ttaggaaaat aaaaaatatt ttagagccaa     2280

gttaacaagt acttcagcaa aacatgctag ttttatgcag gggattctgt attccaaatg     2340

gatacaatcc gacatatata aaagaaacag attcttaact attgactctt atttagcaaa     2400

tgcaacagac aagaatatcc aacttgatat ttataaaagg tagacttttt ccaaaagtgt     2460

ataagctcaa agaaaaaatg caacctgtca attaatatat actatgtaat atatattatt     2520

gtgtatttat gattagccat cataaatgcc cattgcttgg cctttaagaa taatcacaaa     2580

atatttatat taaattatac aaatttgttg cagaagtgcc tgtgagagaa atcttcaaaa     2640

gacaaacctg gtcaaataat aataatttta atgtcaatga ttttttttgt ctgactcatc     2700

tgagttatat ttagttttca agtggcaata aatttatcta ccttcttta                 2749


<210> 1616
<211> 623
<212> DNA
<213> Homo sapiens

<400> 1616
ctcgcacccg gaacaacaaa gcaaggaaga cggagtccga gcctcggggg ctcctagcaa       60

cgggccgggg cgggagttcc atggagactg gggagcgcgc ccgtctcatc ctcatccttg      120

tcctccagct tctccttcgc atccgacgca accggcagca gcgctgccgc cgcgtcctca      180

gccaccgctc cctcttccca cggagcgagg tttcaccagg ctggtctcca actcctgacc      240

tcaaatgatc cacccatctt ggcctcccag agtgctgaga ttacaggcgt gaggcaccac      300

tcctggatgt gatcttcgtg gtggaaagct aaattttaaa accaccccaa tggatgcaga      360

cagtgatgtt gcattggaca ttctaattac aaatgtagtc tgtgttttta gaacaagatg      420

tcatttaaac ttaaggaaga ttgctttgga aggagcaaat gtaatttata aacgtgatgt      480

tggaaaagta ttaatgaagc ttagaaaacc tagaattaca gctacaattt ggtcctcagg      540

aaaaattatt tgcactggag caacaagtga agaagaagct aaatttggtg ccagacgctt      600

agcccgtagt ctgcagaaac tag                                              623


<210> 1617
<211> 808
<212> DNA
<213> Homo sapiens

<400> 1617
atttattgtc gcggggaagc tgcggccgcc tcgcacccgg aacaacaaag caaggaagac       60

ggagtccgag cctcgggggc tcctagcaac gggccggggc gggagttcca tggagactgg      120

ggagcgcgcc cgtctcatcc tcatccttgt cctccagctt ctccttcgca tccgacgcaa      180

ccggcagcag cgctgccgcc gcgtcctcag ccaccgctcc ctcttcccac ggatgtgatc      240

ttcgtggtgg aaagctaaat tttaaaacca ccccaatgga tgcagacagt gatgttgcat      300

tggacattct aattacaaat gtagtctgtg tttttagaac aagatgtcat ttaaacttaa      360

ggaagattgc tttggaagga gcaaatgtaa tttataaacg tgatgttgga aaagtattaa      420

tgaagcttag aaaacctaga attacagcta caatttggtc ctcaggaaaa attatttgca      480

ctggagcaac aagtgaagaa gaagctaaat ttggtgccag acgcttagcc cgtagtctgc      540

agaaactagg ttttcaggta atatttacag attttaaggt tgttaacgtt ctggcagtgt      600

gtaacatgcc atttgaaatc cgtttgccag aattcacaaa gaacaataga cctcatgcca      660

gttacgaacc tgaacttcat cctgctgtgt gctatcggat aaaatctcta agagctacat      720

tacagatttt ttcaacagga agtatcacag taacaggtat tctatgatat tgaaaccaca      780

cttatcaatt atggattgaa tgatacaa                                         808


<210> 1618
<211> 1270
<212> DNA
<213> Homo sapiens

<400> 1618
ggcaggaagc cgccttgtct ctgggcgcgg ccatgttgga ggctccgggc ccgagtgatg       60

gctgcgagct cagcaacccc agcgccagca gagtcagctg tgccgggcag atgctggaag      120

tgcagccagg attgtatttc ggtggggccg cggccgtcgc ggagccagat cacctgaggg      180

aagcgggcat cacggccgtg ctaacagtgg actcggagga gcccagcttc aaggcggggc      240

ctggggtcga ggatctatgg cgcctcttcg tgccagcgct ggacaaaccc gagacggacc      300

tactcagcca tctggaccgg tgcgtggcct tcatcggtca ggcccgcgct gagggccgtg      360

cggtgttggt gcactgtcat gcaggagtca gtcgaagtgt ggccataata actgcttttc      420

tcatgaagac tgaccaactt ccctttgaaa aagcctatga aaagctccag attctcaaac      480

cagaggctaa gatgaatgag gggtttgagt ggcaactgaa attataccag gcaatgggat      540

acgaagtgga tacctctagt gcaatttata agcaatatcg tttacaaaag gttacagaga      600

agtatccaga attgcagaat ttacctcaag aactctttgc tgttgaccca actaccgttt      660

cacaaggatt gaaagatgag gttctctaca agtgtagaaa gtgcaggcga tcattatttc      720

gaagttctag tattctggat caccgtgaag gaagtggacc tatagccttt gcccacaaga      780

gaatgacacc atcttccatg cttaccacag ggaggcaagc tcaatgtaca tcttatttca      840

ttgaacctgt acagtggatg gaatctgctt tgttgggagt gatggatgga cagcttcttt      900

gcccaaaatg cagtgccaag ttgggttcct tcaactggta tggtgaacag tgctcttgtg      960

gtaggtggat aacacctgct tttcaaatac ataagaatag agtggatgaa atgaaaatat     1020

tgcctgtttt gggatcacaa acaggaaaaa tatgaacatg atattttata gcttgggaag     1080

aaacttgcag atgatatgtg ctgcctttgc ttcttatcat tcatggcaga ttgtttgtgc     1140

tttcaacatt tcatttgaaa tgggagaaga taaaatcact tgatgtaacc tggaaactat     1200

gctttacatg gcaatcaaag ccttttgatc atgtacattt tatttgatat taaaatcttt     1260

tataaccaga                                                            1270


<210> 1619
<211> 1172
<212> DNA
<213> Homo sapiens

<400> 1619
cagtcagatc catcatgtgg ccactgacag cccttctgct cctggctact ctggagaagc       60

ccatattgtc tctacatcca ccttggacca ccatcttcaa aggggagcgg gtaactttga      120

agtgtgatgg ataccaccca ctgctcctgg agctccagcc catcagcact ctctggtatt      180

tgggccacct acttctgccc tctcacaaga agagcattga ggtgcagaca ccaggggtgt      240

atcgatgcca gacacgggga gcacccgtca gtgaccccat ccacctctct gtatccaatg      300

attggctgat tctgcaagtg ccctatgcgc cagtgttcga gggtgagccg ctagtcctgc      360

gctgccgcgg ctggtacgac aaggtggtct acaagcttca ctactaccac gacggccagg      420

ccgtgcgcta cttccactcc agcgccaact acactgtgtt acaggcgcgt gccagcgaca      480

gcgggcgcta ccagtgctcg ggcaccatgc gcatcccggt ggagagcgcg cccatgttct      540

ccgctaaggt ggctgtgaca gtgcaagaag cgcgacacgc cgctgcagtt cgcgttttac      600

aagtacagcc gcgcggtgcg ccgcttcgac tggggcgccg agtacacagt cccggagccc      660

gaggtcgagg agctcgaatc gtactggtgc gaggcggcta ccgccacccg cagtgtccgg      720

aaacgcagtc cgtggctgca gctcccgggg ccgggttctc ccctggaccc ggcctccacc      780

accgccccag ctccatgggc cgcagccttg gctcctggta ataggccgct ttccttcaga      840

aagcccccgg tgtccagatc ggtcccgttg gtcacctccg tccggaacac cacctccacc      900

gggctgcagt tcccggcgag cggcgccccg actgcggggc cacccgcctg cgctccgccg      960

acgcccttgg aacaatcggc tggagccctg aaacccgacg tggaccttct gctccgagaa     1020

atgcagctgc tcaaaggcct tctgagccgg gtggtcctgg aattaaagga gccacaggcc     1080

ctccgggagc tcaggggaac gcccgagacc cccacctctc actttgctgt gagcccggga     1140

accccagaga ccactcctgt ggagagctga gg                                   1172


<210> 1620
<211> 1131
<212> DNA
<213> Homo sapiens

<400> 1620
cagtcagatc catcatgtgg ccactgacag cccttctgct cctggctact ctggagaagc       60

ccatattgtc tctacatcca ccttggacca ccatcttcaa aggggagcgg gtaactttga      120

agtgtgatgg ataccaccca ctgctcctgg agctccagcc catcagcact ctctggtatt      180

tgggccacct acttctgccc tctcacaaga agagcattga ggtgcagaca ccaggggtgt      240

atcgatgcca gacacgggga gcacccgtca gtgaccccat ccacctctct gtatccaatg      300

attggctgat tctgcaagtg ccctatgcgc cagtgttcga gggtgagccg ctagtcctgc      360

gctgccgcgg ctggtacgac aaggtggtct acaagcttca ctactaccac gacggccagg      420

ccgtgcgcta cttccactcc agcgccaact acactgtgtt acaggcgcgt gccagcgaca      480

gcgggcgcta ccagtgctcg ggcaccatgc gcatcccggt ggagagcgcg cccatgttct      540

ccgctaaggt ggctgtgaca gtgcaagccg cgcggtgcgc cgcttcgact ggggcgccga      600

gtacacagtc ccggagcccg aggtcgagga gctcgaatcg tactggtgcg aggcggctac      660

cgccacccgc agtgtccgga aacgcagtcc gtggctgcag ctcccggggc cgggttctcc      720

cctggacccg gcctccacca ccgccccagc tccatgggcc gcagccttgg ctcctggtaa      780

taggccgctt tccttcagaa agcccccggt gtccagatcg gtcccgttgg tcacctccgt      840

ccggaacacc acctccaccg ggctgcagtt cccggcgagc ggcgccccga ctgcggggcc      900

acccgcctgc gctccgccga cgcccttgga acaatcggct ggagccctga aacccgacgt      960

ggaccttctg ctccgagaaa tgcagctgct caaaggcctt ctgagccggg tggtcctgga     1020

attaaaggag ccacaggccc tccgggagct caggggaacg cccgagaccc ccacctctca     1080

ctttgctgtg agcccgggaa ccccagagac cactcctgtg gagagctgag g              1131


<210> 1621
<211> 1152
<212> DNA
<213> Homo sapiens

<400> 1621
cagtcagatc catcatgtgg ccactgacag cccttctgct cctggttcca agcagtgggc       60

aagctgctac tctggagaag cccatattgt ctctacatcc accttggacc accatcttca      120

aaggggagcg ggtaactttg aagtgtgatg gataccaccc actgctcctg gagctccagc      180

ccatcagcac tctctggtat ttgggccacc tacttctgcc ctctcacaag aagagcattg      240

aggtgcagac accaggggtg tatcgatgcc agacacgggg agcacccgtc agtgacccca      300

tccacctctc tgtatccaat gattggctga ttctgcaagt gccctatgcg ccagtgttcg      360

agggtgagcc gctagtcctg cgctgccgcg gctggtacga caaggtggtc tacaagcttc      420

actactacca cgacggccag gccgtgcgct acttccactc cagcgccaac tacactgtgt      480

tacaggcgcg tgccagcgac agcgggcgct accagtgctc gggcaccatg cgcatcccgg      540

tggagagcgc gcccatgttc tccgctaagg tggctgtgac agtgcaagcc gcgcggtgcg      600

ccgcttcgac tggggcgccg agtacacagt cccggagccc gaggtcgagg agctcgaatc      660

gtactggtgc gaggcggcta ccgccacccg cagtgtccgg aaacgcagtc cgtggctgca      720

gctcccgggg ccgggttctc ccctggaccc ggcctccacc accgccccag ctccatgggc      780

cgcagccttg gctcctggta ataggccgct ttccttcaga aagcccccgg tgtccagatc      840

ggtcccgttg gtcacctccg tccggaacac cacctccacc gggctgcagt tcccggcgag      900

cggcgccccg actgcggggc cacccgcctg cgctccgccg acgcccttgg aacaatcggc      960

tggagccctg aaacccgacg tggaccttct gctccgagaa atgcagctgc tcaaaggcct     1020

tctgagccgg gtggtcctgg aattaaagga gccacaggcc ctccgggagc tcaggggaac     1080

gcccgagacc cccacctctc actttgctgt gagcccggga accccagaga ccactcctgt     1140

ggagagctga gg                                                         1152


<210> 1622
<211> 1977
<212> DNA
<213> Homo sapiens

<400> 1622
aagatactat cttcctggga gttgacagta cctgataatt gatctccttc ccatcagatt       60

tccaagggat caaggtgccc cggttctaaa caaccacagg tacggtcaca tggctcagaa      120

agcacaagaa gtagagcccc gaggtcagat ctgagaggct tctgaggggc cgatgcagtg      180

acttctctgc tgcagctgct gcagtcagat ccatcatgtg gccactgaca gcccttctgc      240

tcctggttcc aagcagtggg caagctgcta ctctggagaa gcccatattg tctctacatc      300

caccttggac caccatcttc aaaggggagc gggtaacttt gaagtgtgat ggataccacc      360

cactgctcct ggagctccag cccatcagca ctctctggta tttgggccac ctacttctgc      420

cctctcacaa gaagagcatt gaggtgcaga caccaggggt gtatcgatgc cagacacggg      480

gagcacccgt cagtgacccc atccacctct ctgtatccaa tgattggctg attctgcaag      540

tgccctatgc gccagtgttc gagggtgagc cgctagtcct gcgctgccgc ggctggtacg      600

acaaggtggt ctacaagctt cactactacc acgacggcca ggccgtgcgc tacttccact      660

ccagcgccaa ctacactgtg ttacaggcgc gtgccagcga cagcgggcgc taccagtgct      720

cgggcaccat gcgcatcccg gtggagagcg cgcccatgtt ctccgctaag gtggctgtga      780

cagtgcaaga gctgttccgg gcgccggtgc tgagggtgat gggtccgcgg gaggcccgcg      840

gcgcggcgct gggtggggtg gtgctgcgct gcgacacgcg cctgcacccg cagaagcgcg      900

acacgccgct gcagttcgcg ttttacaagt acagccgcgc ggtgcgccgc ttcgactggg      960

gcgccgagta cacagtcccg gagcccgagg tcgaggagct cgaatcgtac tggtgcgagg     1020

cggctaccgc cacccgcagt gtccggaaac gcagtccgtg gctgcagctc ccggggccgg     1080

gttctcccct ggacccggcc tccaccaccg ccccagctcc atgggccgca gccttggctc     1140

ctggtaatag gccgctttcc ttcagaaagc ccccggtgtc cagatcggtc ccgttggtca     1200

cctccgtccg gaacaccacc tccaccgggc tgcagttccc ggcgagcggc gccccgactg     1260

cggggccacc cgcctgcgct ccgccgacgc ccttggaaca atcggctgga gccctgaaac     1320

ccgacgtgga ccttctgctc cgagaaatgc agctgctcaa aggccttctg agccgggtgg     1380

tcctggaatt aaaggagcca caggccctcc gggagctcag gggaacgccc gagaccccca     1440

cctctcactt tgctgtgagc ccgggaaccc cagagaccac tcctgtggag agctgagggg     1500

gcggctaccg tcccctctgc aggctcattc ctccttggtc tcctgcttcc cctcacgcga     1560

atttctttca aagccatctg tttgcatcct tgtgttttgc tgtggttttt aaaggagcgc     1620

ccacgaagtg tagtggctga cgatttcaac ctcacacagc agtttgtaac cgcaagcatt     1680

ctctttgaat tctcacagaa ttcagcaaga agtagaaacc tgttatttac tacattgtga     1740

tttaactttg gatgtgaatt tagtcaccct tagcccttca gataagccta gccagtacat     1800

atttcagcac aggcagtttt tttggtattt aagtacattg aggtaactga gcacttgaga     1860

atattttagg gtcaaagtgt aattattcat aatgaattta ctctgttgat attaaaaaga     1920

cgttcagtcc tattactgat gagtttacat cttcaaataa atcctgggtt ctattta        1977


<210> 1623
<211> 574
<212> DNA
<213> Homo sapiens

<400> 1623
gcaggcgccg agagggcggg ccagggccgc actccggaga ctcgcggttg ctacgcgcac       60

catggctgga ggctgtcgcg ccccttcctc agcgcccacg gtctcgcttc ctgaactccg      120

ttcactccta gcctccggac gggcccggct cttcgacgtg cgctctcgcg aggaggcggc      180

agctgggacc atcccagggg cgctcaacat cccggtgtcc gagttggaga gtgctctgca      240

gatggagcca gctgccttcc aggctttata ttctgctgag aagccaaagc tggaagatga      300

gcatctcgtt ttcttctgtc agatgggcaa gcggggcctc caggccacgc agctggcccg      360

gagtcttgga tacactgggg ctcgcaacta cgctggagcc tatagagaat ggttggagaa      420

agagagttag gcaggaggca gcttactgat tgccaccccc tggcccctta atggccacct      480

taactaaggg tgtgaacggg ctgacttggt gaattgggca actccttata gtgttgtgca      540

cacaaaagca tcaaataaag aacatttaat caaa                                  574


<210> 1624
<211> 457
<212> DNA
<213> Homo sapiens

<400> 1624
cagctctggg agggaacggg agatgttgca ggcgccgaga gggcgggcca gggccgcact       60

ccggagactc gcggttgcta cgcgcaccat ggctggagtg tccgagttgg agagtgctct      120

gcagatggag ccagctgcct tccaggcttt atattctgct gagaagccaa agctggaaga      180

tgagcatctc gttttcttct gtcagatggg caagcggggc ctccaggcca cgcagctggc      240

ccggagtctt ggatacactg gggctcgcaa ctacgctgga gcctatagag aatggttgga      300

gaaagagagt taggcaggag gcagcttact gattgccacc ccctggcccc ttaatggcca      360

ccttaactaa gggtgtgaac gggctgactt ggtgaattgg gcaactcctt atagtgttgt      420

gcacacaaaa gcatcaaata aagaacattt aatcaaa                               457


<210> 1625
<211> 4106
<212> DNA
<213> Homo sapiens

<400> 1625
agtgtaagat ggcggcggcg ttggtggtgg cagtggacgg ggcggctggg cctggaacag       60

tcggagcagc cgctagcaga aggatgaccc aagacgggaa gcgggctgct gagcctcgcc      120

gattcccgtg cttgtaactg ccccagccgg acaccccccc tcccttgacc tacccggtct      180

gtgtctcgtt ccggctcggc ctgcgccccc cctcgcttcc cagccggttt cccctaagga      240

tgggcctgac ccgtatccca agctcttagc gctcaggtct tttccttccg ccgacccgaa      300

gtcatcgctg ggagtactgg ttgccctttc ctcagtcctt cagtgaatct acagacctat      360

tttctcagga gctcagcctg gccttacttc agtgataaaa ggaggaaagg ctggctacag      420

caaacatcat tcaagatgtc cagcaaaggg agcagcacag atggcagaac agacttagct      480

aatggaagcc tgtctagcag tccagaggag atgtctggag ctgaagaggg gagggagaca      540

tcctcaggca ttgaagtgga ggcctcagac ctgagtttga gcttgactgg ggatgatggt      600

ggccccaacc gcaccagcac agaaagtcga ggcacagaca cagagagctc aggtgaagat      660

aaggactctg acagcatgga ggacactggt cattactcca ttaatgatga aaatcgagtc      720

catgaccgct cagaggaaga ggaagaggag gaagaagagg aggaagaaga gcagcctcgg      780

cgccgtgtac agcgcaagcg ggctaaccgt gaccaggact catcagatga tgagcgggcc      840

ctagaggact gggtgtcctc agaaacatca gctctacccc gacctcgctg gcaagccctc      900

cctgcccttc gggagcggga gctgggttca agtgcccgct ttgtctatga ggcctgtggg      960

gcaagagtct ttgtgcagcg tttccgcctg cagcatgggc ttgagggcca tactggttgt     1020

gtcaataccc tgcactttaa ccagcgcggc acctggctgg ccagtggcag cgatgacctg     1080

aaggtggtgg tgtgggattg ggtacggcgg cagccagtac tggactttga gagtggccac     1140

aaaagtaatg tgttccaggc caagtttctt cctaacagtg gtgattctac tctggccatg     1200

tgtgcccgtg acgggcaggt tcgagtagca gaactgtctg ccacacagtg ttgcaagaat     1260

acaaaacgtg tggcccagca caagggagcg tcccacaagt tggcactgga accagactct     1320

ccctgtacgt tcttatctgc aggtgaagat gcagttgttt tcaccattga cctgagacaa     1380

gaccgcccag cgtcgaaact ggtggtgaca aaagagaaag agaagaaagt ggggctgtat     1440

acgatctatg tgaatcctgc caatacccac cagtttgcag tgggtggacg agatcagttt     1500

gtaaggattt atgaccagag gaaaattgat gagaatgaga acaatggagt actcaagaag     1560

ttctgtcctc atcacctggt gaacagtgag tccaaagcaa acatcacctg tcttgtgtac     1620

agccacgacg gcacagagct cctggccagt tacaatgatg aagacattta cctcttcaac     1680

tcctctcaca gtgatggggc ccagtatgtt aagagataca agggccacag aaataatgcc     1740

acagtaaaag gcgtcaattt ctatggcccc aagagtgagt ttgtggtgag cggtagtgac     1800

tgtgggcaca tcttcctctg ggagaaatca tcctgccaga ttattcagtt catggagggg     1860

gacaagggag gcgtggtaaa ctgtcttgag ccccaccctc acctgcctgt gctggcaacc     1920

agtggcctag accatgatgt gaagatctgg gcacccacag ctgaagcttc cactgagctg     1980

acagggttaa aagatgtgat taagaagaac aagcgggagc gggatgaaga tagcttgcac     2040

caaactgacc tgtttgatag tcacatgctg tggttcctta tgcatcacct gagacagaga     2100

cgccatcacc ggcgctggcg agaacctggg gttggggcca cagacgcgga ctctgatgag     2160

tctcccagct cctcagacac atcggacgag gaggagggcc ctgaccgggt gcagtgcatg     2220

ccatcttgag gcctcatacc taggtggggc aggctggggc tgccaacctg atcctgcctg     2280

ggcaaccctt tcctgtccca ggccctacat tcagcagaaa cgcactttgg actttttgct     2340

ttagataaaa gaaagacatc ccaggagaag gacaaaccag aggagtgaac caacaaagag     2400

tacctaggaa tgggagttga gccctggaat ggggctctat ggagaggtgc ataggactcg     2460

gcagaaatgg cctctcccca aagcctcttt ttgagaggag agggaagcct attttgttaa     2520

ctggtttggg atagggaatg gggtttcttt ttctttaatc tcccttgttt cttgggctgg     2580

gggaggggtg gggggaacaa ctggctattc agtaccaagg ggccagagtg gagggtagga     2640

gtgccactct ctctttggtt taggtttttg accttttctt cctttgtttt ttaaaagttt     2700

atgacagttg gctccccccc cacccccagc aaccccatcc cagaatccta ttttcctggg     2760

aagtccttaa agcccctaac catcccacac tcttcacttt cctttccacc ttattcattc     2820

tctgtactta ccacagtatt ttgcacttga ttacatatcc ttcactctct tctcttcatc     2880

ccatcacccc ctaaataggt caggtgaggg aggctgggaa gaggtgggag gaggggcaga     2940

agtgaaggaa gaataggaag gatattacct cttctgttat ttttttaaga aacattgttt     3000

ggtggcagca atctccctgt ccctatcact gttagaggcc taattttata tctataaata     3060

tattaaaaag caagtcaaac ttggatgtat caaggtaaaa ttattgtcaa agtttaaata     3120

cctatatatt ctctgaatgc aataaaggga cttaagagtg aacaagagta atggtgtgga     3180

agtgacacct ggggtcagtt tacctctgtg tatggtcact agagattggg acttaccctt     3240

taggttttag gaggcttgag aatggaagga tcctcatttc tgcccttcct ggttccctgc     3300

tttggtgtag gggttgggaa aaacaggaaa ttcctctcag ctctgcctca gatctcctac     3360

ctctccttaa gtcttgtagg gggttccaag gatggctctt ctaaccagag gctggcctgt     3420

ctttaaaact taactacttt agggtggtgc caccactgca gactattgtg gtactttgtg     3480

acagaagaca tgtacacaca caccacacac atacatacac actctctcac tctgtctctc     3540

ttacctttag ctgcttgatc attaagccat ccaacttcat gccagttccc ttctttatag     3600

aagagtgaag ggaaagactt cctgggtttg acttaaacct tgtccacctc ttgatatttt     3660

aggattgagg aataagtcat taatctaagg actgattaca gtggctggag cttgggcact     3720

tgtcttatca ctggtcactg agtctgaaag tcccagctga attcttgccc ttaagtgctt     3780

ttgctgctat ttttttgccc ccagttccac aagatccaac caagaattct gtatcctggg     3840

acagtcagat tcttctaaat caggccagga aggaggggaa aagagtgaga gaatggtatt     3900

cccagatact tcttcctcct gccccttttc ccagcagctc tgagaccaga tgttggctgc     3960

tgtacttact ccctgaggta gggaatgtgt ggtgatcgag tggtctgtgt tcctattgct     4020

ggtggggtga tagggtgggc taaaaaccat gcactctgga atttgttgta ttttctccca     4080

gtaaagcttt tcttctcccg actgct                                          4106


<210> 1626
<211> 3824
<212> DNA
<213> Homo sapiens

<400> 1626
gcaggcgcaa gcgcagagag cggaggcggt ggtggtggcg gccgctggcc agttccttca       60

gtgaatctac agacctattt tctcaggagc tcagcctggc cttacttcag tgataaaagg      120

aggaaaggct ggctacagca aacatcattc aagatgtcca gcaaagggag cagcacagat      180

ggcagaacag acttagctaa tggaagcctg tctagcagtc cagaggagat gtctggagct      240

gaagagggga gggagacatc ctcaggcatt gaagtggagg cctcagacct gagtttgagc      300

ttgactgggg atgatggtgg ccccaaccgc accagcacag aaagtcgagg cacagacaca      360

gagagctcag gtgaagataa ggactctgac agcatggagg acactggtca ttactccatt      420

aatgatgaaa atcgagtcca tgaccgctca gaggaagagg aagaggagga agaagaggag      480

gaagaagagc agcctcggcg ccgtgtacag cgcaagcggg ctaaccgtga ccaggactca      540

tcagatgatg agcgggccct agaggactgg gtgtcctcag aaacatcagc tctaccccga      600

cctcgctggc aagccctccc tgcccttcgg gagcgggagc tgggttcaag tgcccgcttt      660

gtctatgagg cctgtggggc aagagtcttt gtgcagcgtt tccgcctgca gcatgggctt      720

gagggccata ctggttgtgt caataccctg cactttaacc agcgcggcac ctggctggcc      780

agtggcagcg atgacctgaa ggtggtggtg tgggattggg tacggcggca gccagtactg      840

gactttgaga gtggccacaa aagtaatgtg ttccaggcca agtttcttcc taacagtggt      900

gattctactc tggccatgtg tgcccgtgac gggcaggttc gagtagcaga actgtctgcc      960

acacagtgtt gcaagaatac aaaacgtgtg gcccagcaca agggagcgtc ccacaagttg     1020

gcactggaac cagactctcc ctgtacgttc ttatctgcag gtgaagatgc agttgttttc     1080

accattgacc tgagacaaga ccgcccagcg tcgaaactgg tggtgacaaa agagaaagag     1140

aagaaagtgg ggctgtatac gatctatgtg aatcctgcca atacccacca gtttgcagtg     1200

ggtggacgag atcagtttgt aaggatttat gaccagagga aaattgatga gaatgagaac     1260

aatggagtac tcaagaagtt ctgtcctcat cacctggtga acagtgagtc caaagcaaac     1320

atcacctgtc ttgtgtacag ccacgacggc acagagctcc tggccagtta caatgatgaa     1380

gacatttacc tcttcaactc ctctcacagt gatggggccc agtatgttaa gagatacaag     1440

ggccacagaa ataatgccac agtaaaaggc gtcaatttct atggccccaa gagtgagttt     1500

gtggtgagcg gtagtgactg tgggcacatc ttcctctggg agaaatcatc ctgccagatt     1560

attcagttca tggaggggga caagggaggc gtggtaaact gtcttgagcc ccaccctcac     1620

ctgcctgtgc tggcaaccag tggcctagac catgatgtga agatctgggc acccacagct     1680

gaagcttcca ctgagctgac agggttaaaa gatgtgatta agaagaacaa gcgggagcgg     1740

gatgaagata gcttgcacca aactgacctg tttgatagtc acatgctgtg gttccttatg     1800

catcacctga gacagagacg ccatcaccgg cgctggcgag aacctggggt tggggccaca     1860

gacgcggact ctgatgagtc tcccagctcc tcagacacat cggacgagga ggagggccct     1920

gaccgggtgc agtgcatgcc atcttgaggc ctcataccta ggtggggcag gctggggctg     1980

ccaacctgat cctgcctggg caaccctttc ctgtcccagg ccctacattc agcagaaacg     2040

cactttggac tttttgcttt agataaaaga aagacatccc aggagaagga caaaccagag     2100

gagtgaacca acaaagagta cctaggaatg ggagttgagc cctggaatgg ggctctatgg     2160

agaggtgcat aggactcggc agaaatggcc tctccccaaa gcctcttttt gagaggagag     2220

ggaagcctat tttgttaact ggtttgggat agggaatggg gtttcttttt ctttaatctc     2280

ccttgtttct tgggctgggg gaggggtggg gggaacaact ggctattcag taccaagggg     2340

ccagagtgga gggtaggagt gccactctct ctttggttta ggtttttgac cttttcttcc     2400

tttgtttttt aaaagtttat gacagttggc tcccccccca cccccagcaa ccccatccca     2460

gaatcctatt ttcctgggaa gtccttaaag cccctaacca tcccacactc ttcactttcc     2520

tttccacctt attcattctc tgtacttacc acagtatttt gcacttgatt acatatcctt     2580

cactctcttc tcttcatccc atcaccccct aaataggtca ggtgagggag gctgggaaga     2640

ggtgggagga ggggcagaag tgaaggaaga ataggaagga tattacctct tctgttattt     2700

ttttaagaaa cattgtttgg tggcagcaat ctccctgtcc ctatcactgt tagaggccta     2760

attttatatc tataaatata ttaaaaagca agtcaaactt ggatgtatca aggtaaaatt     2820

attgtcaaag tttaaatacc tatatattct ctgaatgcaa taaagggact taagagtgaa     2880

caagagtaat ggtgtggaag tgacacctgg ggtcagttta cctctgtgta tggtcactag     2940

agattgggac ttacccttta ggttttagga ggcttgagaa tggaaggatc ctcatttctg     3000

cccttcctgg ttccctgctt tggtgtaggg gttgggaaaa acaggaaatt cctctcagct     3060

ctgcctcaga tctcctacct ctccttaagt cttgtagggg gttccaagga tggctcttct     3120

aaccagaggc tggcctgtct ttaaaactta actactttag ggtggtgcca ccactgcaga     3180

ctattgtggt actttgtgac agaagacatg tacacacaca ccacacacat acatacacac     3240

tctctcactc tgtctctctt acctttagct gcttgatcat taagccatcc aacttcatgc     3300

cagttccctt ctttatagaa gagtgaaggg aaagacttcc tgggtttgac ttaaaccttg     3360

tccacctctt gatattttag gattgaggaa taagtcatta atctaaggac tgattacagt     3420

ggctggagct tgggcacttg tcttatcact ggtcactgag tctgaaagtc ccagctgaat     3480

tcttgccctt aagtgctttt gctgctattt ttttgccccc agttccacaa gatccaacca     3540

agaattctgt atcctgggac agtcagattc ttctaaatca ggccaggaag gaggggaaaa     3600

gagtgagaga atggtattcc cagatacttc ttcctcctgc cccttttccc agcagctctg     3660

agaccagatg ttggctgctg tacttactcc ctgaggtagg gaatgtgtgg tgatcgagtg     3720

gtctgtgttc ctattgctgg tggggtgata gggtgggcta aaaaccatgc actctggaat     3780

ttgttgtatt ttctcccagt aaagcttttc ttctcccgac tgct                      3824


<210> 1627
<211> 756
<212> DNA
<213> Homo sapiens

<400> 1627
gagttacttg gctcggagcg ggcgagggga cgcgtgggcg gagcggggct ggccagcctc       60

ggcccccatg acccgctgtc ctgtgccctt tcccagcgat gggcgtgcag ccccccaact      120

tctcctgggt gcttccgggc cggctggcgg gactggcgct gccgcggctc cccgcccact      180

accagttcct gttggacctg ggcgtgcggc acctggtgtc cctgacggag cgcgggcccc      240

ctcacagcga cagctgcccc ggcctcaccc tgcaccgcct gcgcatcccc gacttctgcc      300

cgccggcccc cgaccagatc gaccgcttcg tgcagatcgt ggacgaggcc aacgcacggg      360

gagaggctgt gggagtgcac tgtgctctgg gctttggccg cactggcacc atgctggcct      420

gttacctggt gaaggagcgg ggcttggctg caggagatgc cattgctgaa atccgacgac      480

tacgacccgg ctccatcgag acctatgagc aggagaaagc agtcttccag ttctaccagc      540

gaacgaaata aggggcctta gtacccttct accaggccct cactcccctt ccccatgttg      600

tcgatggggc cagagatgaa gggaagtgga ctaaagtatt aaaccctcta gctcccattg      660

gctgaagaca ctgaagtagc ccacccctgc aggcaggtcc tgattgaagg ggaggcttgt      720

actgctttgt tgaataaatg agttttacga accagg                                756


<210> 1628
<211> 694
<212> DNA
<213> Homo sapiens

<400> 1628
gcagaccacg tggcccggga ggcgccgagg ccagcgatgg gcgtgcagcc ccccaacttc       60

tcctgggtgc ttccgggccg gctggcggga ctggcgctgc cgcggctccc cgcccactac      120

cagttcctgt tggacctggg cgtgcggcac ctggtgtccc tgacggagcg cgggccccct      180

cacagcgaca gctgccccgg cctcaccctg caccgcctgc gcatccccga cttctgcccg      240

ccggcccccg accagatcga ccgcttcgtg cagatcgtgg acgaggccaa cgcacgggga      300

gaggctgtgg gagtgcactg tgctctgggc tttggccgca ctggcaccat gctggcctgt      360

tacctggtga aggagcgggg cttggctgca ggagatgcca ttgctgaaat ccgacgacta      420

cgacccggct ccatcgagac ctatgagcag gagaaagcag tcttccagtt ctaccagcga      480

acgaaataag gggccttagt acccttctac caggccctca ctccccttcc ccatgttgtc      540

gatggggcca gagatgaagg gaagtggact aaagtattaa accctctagc tcccattggc      600

tgaagacact gaagtagccc acccctgcag gcaggtcctg attgaagggg aggcttgtac      660

tgctttgttg aataaatgag ttttacgaac cagg                                  694


<210> 1629
<211> 729
<212> DNA
<213> Homo sapiens

<400> 1629
gggcagagcg acccgagggc ggcgccctgc agaccacgtg gcccgggagg cgccgaggcc       60

aggtaggtgc gatgggcgtg cagcccccca acttctcctg ggtgcttccg ggccggctgg      120

cgggactggc gctgccgcgg ctccccgccc actaccagtt cctgttggac ctgggcgtgc      180

ggcacctggt gtccctgacg gagcgcgggc cccctcacag cgacagctgc cccggcctca      240

ccctgcaccg cctgcgcatc cccgacttct gcccgccggc ccccgaccag atcgaccgct      300

tcgtgcagat cgtggacgag gccaacgcac ggggagaggc tgtgggagtg cactgtgctc      360

tgggctttgg ccgcactggc accatgctgg cctgttacct ggtgaaggag cggggcttgg      420

ctgcaggaga tgccattgct gaaatccgac gactacgacc cggctccatc gagacctatg      480

agcaggagaa agcagtcttc cagttctacc agcgaacgaa ataaggggcc ttagtaccct      540

tctaccaggc cctcactccc cttccccatg ttgtcgatgg ggccagagat gaagggaagt      600

ggactaaagt attaaaccct ctagctccca ttggctgaag acactgaagt agcccacccc      660

tgcaggcagg tcctgattga aggggaggct tgtactgctt tgttgaataa atgagtttta      720

cgaaccagg                                                              729


<210> 1630
<211> 5558
<212> DNA
<213> Homo sapiens

<400> 1630
gctactccca ccccgccccg ccccgtcatt gtccccgtcg gtctcttttc tcttccgtcc       60

taaaagctct gcgagccgct cccttctccc ggtgccccgc gtctgtccat cctcagtggg      120

tcagacgagc aggatggagg gctgcatggg ggaggagtcg tttcagatgt gggagctcaa      180

tcggcgcctg gaggcctacc tggcccgggt caaggcgctg gaggagcaga atgagctgct      240

cagcgcggag ctcggggggc tccgggcaca atccgcggac acctcctggc gggcgcatgc      300

cgacgacgag ctggcggccc tgcgggccct cgttgaccaa cgctggcggg agaagcacgc      360

ggccgaggtg gcgcgcgaca acctggctga agagctggag ggcgtggcag gccgatgcca      420

gcagctgcgg ctggcccggg agcggacgac ggaggaggta gcccgcaacc ggcgcgccgt      480

cgaggcagag aaatgcgccc gggcctggct gagtagccag gtggcagagc tggagcgcga      540

gctagaggct ctacgcgtgg cgcacgagga ggagcgcgtc ggcctgaacg cgcaggctgc      600

ctgtgccccc cgctgccccg cgccgccccg cgggcctccc gcgccggccc cggaggtaga      660

ggagctggca aggcgactgg gcgaggcgtg gcgcggggca gtgcgcggct accaggagcg      720

cgtggcacac atggagacgt cgctgggcca ggcccgcgag cggctgggcc gggcggtgca      780

gggtgcccgc gagggccgcc tggagctgca gcagctccag gctgagcgcg gaggcctcct      840

ggagcgcagg gcagcgttgg aacagaggtt ggagggccgc tggcaggagc ggctgcgggc      900

tactgaaaag ttccagctgg ctgtggaggc cctggagcag gagaaacagg gcctacagag      960

ccagatcgct caggtcctgg aaggtcggca gcagctggcg cacctcaaga tgtccctcag     1020

cctggaggtg gccacgtaca ggaccctcct ggaggctgag aactcccggc tgcaaacacc     1080

tggcggtggc tccaagactt ccctcagctt tcaggacccc aagctggagc tgcaattccc     1140

taggacccca gagggccggc gtcttggatc tttgctccca gtcctgagcc caacttccct     1200

cccctcaccc ttgcctgcta cccttgagac acctgtgcca gcctttctta agaaccaaga     1260

attcctccag gcccgtaccc ctaccttggc cagcaccccc atccccccca cacctcaggc     1320

accctctcct gctgtagatg cagagatcag agcccaggat gctcctctct ctctgctcca     1380

gacacagggt gggaggaaac aggctccaga gcccctgcgg gctgaagcca gggtggccat     1440

tcctgccagc gtcctgcctg gaccagagga gcctgggggc cagcggcaag aggccagtac     1500

aggccagtcc ccagaggacc atgcctcctt ggcaccaccc ctcagccctg accactccag     1560

tttagaggct aaggatggag aatccggtgg gtctagagtg ttcagcatat gccgagggga     1620

aggtgaaggg caaatctggg ggttggtaga gaaagaaaca gccatagagg gcaaagtggt     1680

aagcagcttg cagcaggaaa tatgggaaga agaggatcta aacaggaagg aaatccagga     1740

ctcccaggtt cctttggaaa aagaaaccct gaagtctctg ggagaggaga ttcaagagtc     1800

actgaagact ctggaaaacc agagccatga gacactagaa agggagaatc aagaatgtcc     1860

gaggtcttta gaagaagact tagaaacact aaaaagtcta gaaaaggaaa ataaagagct     1920

attaaaggat gtggaggtag tgagacctct agaaaaagag gctgtaggcc aacttaagcc     1980

tacaggaaaa gaggacacac agacattgca atccctgcaa aaggagaatc aagaactaat     2040

gaaatctctt gaaggtaatc tagagacatt tttatttcca ggaacggaaa atcaagaatt     2100

agtaagttct ctgcaagaga acttagagtc attgacagct ctggaaaagg agaatcaaga     2160

gccactgaga tctccagaag taggggatga ggaggcactg agacctctga caaaggagaa     2220

tcaggaaccc ctgaggtctc ttgaagatga gaacaaagag gcctttagat ctctagaaaa     2280

agagaaccag gagccactga agactctaga agaagaggac cagagtattg tgagacctct     2340

agaaacagag aatcacaaat cactgaggtc tttagaagaa caggaccaag agacattgag     2400

aactcttgaa aaagagactc aacagcgacg gaggtctcta ggggaacagg atcagatgac     2460

attaagaccc ccagaaaaag tggatctaga accactgaag tctcttgacc aggagatagc     2520

tagacctctt gaaaatgaga atcaagagtt cttaaagtca ctcaaagaag agagcgtaga     2580

ggcagtaaaa tctttagaaa cagagatcct agaatcactg aagtctgcgg gacaagagaa     2640

cctggaaaca ctgaaatctc cagaaactca agcaccactg tggactccag aagaaataaa     2700

tcagggggca atgaatcctc tagaaaagga aattcaagaa ccactggagt ctgtggaagt     2760

gaaccaagag acattcagac tcctggaaga ggagaatcag gaatcattga gatctctggg     2820

agcatggaac ctggagaatt tgagatctcc agaggaggta gacaaggaaa gtcaaaggaa     2880

tctggaagag gaagagaacc tgggaaaggg agagtaccaa gagtcactga ggtctctgga     2940

ggaggaggga caggagctgc cgcagtctgc agatgtgcag aggtgggaag atacggtgga     3000

gaaggaccaa gaactggctc aggaaagccc tcctgggatg gctggagtgg aaaatgagga     3060

tgaggcagag ctgaatctga gggagcagga tggcttcact gggaaggagg aggtggtaga     3120

gcagggagag ctgaatgcca cagaggaggt ctggatccca ggcgaggggc acccagagag     3180

ccctgagccc aaagagcaga gaggcctggt tgagggagcc agtgtgaagg gaggggctga     3240

gggcctccag gaccctgaag ggcaatcaca acaggtgggg gccccaggcc tccaggctcc     3300

ccaggggctg ccagaggcga tagagcccct ggtggaagat gatgtggccc cagggggtga     3360

ccaagcctcc ccagaggtca tgttggggtc agagcctgcc atgggtgagt ctgctgcggg     3420

agctgagcca ggcccggggc agggggtggg agggctgggg gacccaggcc atctgaccag     3480

ggaagaggtg atggaaccac ccctggaaga ggagagtttg gaggcaaaga gggttcaggg     3540

cttggaaggg cctagaaagg acctagagga ggcaggtggt ctggggacag agttctccga     3600

gctgcctggg aagagcagag acccttggga gcctcccagg gagggtaggg aggagtcaga     3660

ggctgaggcc cccaggggag cagaggaggc gttccctgct gagaccctgg gccacactgg     3720

aagtgatgcc ccttcacctt ggcctctggg gtcagaggaa gctgaggagg atgtaccacc     3780

agtgctggtc tcccccagcc caacgtacac cccgatcctg gaagatgccc ctgggcctca     3840

gcctcaggct gaagggagtc aggaggctag ctggggggtg caggggaggg ctgaagccct     3900

ggggaaagta gagagcgagc aggaggagtt gggttctggg gagatccccg agggccccca     3960

ggaggaaggg gaggagagca gagaagagag cgaggaggat gagctcgggg agacccttcc     4020

agactccact cccctgggct tctacctcag gtcccccacc tcccccaggt gggaccccac     4080

tggagagcag aggccacccc ctcaagggga gactggaaag gagggctggg atcctgctgt     4140

cctggcttcc gagggccttg aggccccacc ctcagaaaag gaggaggggg aggagggaga     4200

agaggagtgt ggccgtgact ctgacctgtc agaagaattt gaggacctgg ggactgaggc     4260

accttttctt cctggggtcc ctggggaggt ggcagaacct ctgggccagg tgccccagct     4320

gctactggat cctgcagcct gggatcgaga tggggagtcc gatgggtttg cagatgagga     4380

agaaagtggg gaggagggag aggaggatca ggaggagggg agggagccag gggctgggcg     4440

gtgggggcca gggtcttctg ttggcagcct ccaggccctg agtagctccc agagagggga     4500

attcctggag tctgattctg tgagtgtcag tgtcccctgg gatgacagct tgaggggtgc     4560

agtggctggt gcccccaaga ctgccctgga aacggagtcc caggacagtg ctgagccttc     4620

tggctcagag gaagagtctg accctgtttc cttggagagg gaggacaaag tccctggccc     4680

tctagagatc cccagtggga tggaggatgc aggcccaggg gcagacatca ttggtgttaa     4740

tggccagggt cccaacttgg aggggaagtc acagcatgtg aatgggggag tgatgaacgg     4800

gctggagcag tctgaggaag tggggcaagg aatgccgcta gtctctgagg gagaccgagg     4860

gagccccttt caggaggagg aggggagtgc tctgaagacc tcttgggcag gggctcctgt     4920

tcacctgggc cagggtcagt tcctgaagtt cactcagagg gaaggagata gagagtcctg     4980

gtcctcaggg gaggactagg aaaagaccat ctgcccggca ctggggactt aggggtgcgg     5040

ggaggggaag gacgcctcca agcccgctcc ctgctcagga gcagcactct taacttacga     5100

tctcttgaca tatggtttct ggctgagagg cctggcccgc taaggtgaaa aggggtgtgg     5160

caaaggagcc tactccaaga atggaggctg taggaatata acctcccacc ctgcaaaggg     5220

aatctcttgc ctgctccatc tcataggcta agtcagctga atcccgatag tactaggtcc     5280

ccttccctcc gcatcccgtc agctggaaaa ggcctgtggc ccagaggctt ctccaaaggg     5340

agggtgacat gctggctttt gtgcccaagc tcaccagccc tgcgccacct cactgcagta     5400

gtgcaccatc tcactgcagt agcacgccct cctgggccgt ctggcctgtg gctaatggag     5460

gtgacggcac tcccatgtgc tgactccccc catccctgcc acgctgtggc cctgcctggc     5520

tagtccctgc ctgaataaag taatgcctcc gcttcaaa                             5558


<210> 1631
<211> 438
<212> DNA
<213> Homo sapiens

<400> 1631
tgaggctgtg agcagtaccg gagggcacca cacctgttgg tgttcagatg gagcggcaca       60

ctagtcatcc taacagaaaa gttccagcca aagaggaagc taatgctgtg cctctctgta      120

gagcaaaacc ctcccccagc tatattaatc ttcaagcaag ttccccacca gccacttttc      180

tgaacatcca gacaacaaag ctgccctcgg ttgatcacaa gcccaaggaa tgcctaggac      240

tcctggaatg tatgtatgca aacctccagc ttcagaccca gctcgcccaa caacagatgg      300

ctgttttgga acatttacag gcatctgtga cacaactggc tcctgggagg ggaagcaata      360

actcttctct cccagcctta tctcctaatc cattgttaaa tcacctgccc caattcagta      420

aatgaattgt ggaacaaa                                                    438


<210> 1632
<211> 491
<212> DNA
<213> Homo sapiens

<400> 1632
agccttagca acaggtggac tagagaggcg ggactccagc cagcacatgg gggaaagacc       60

tgccggcttg gcgcagggca ccacacctgt tggtgttcag atggagcggc acactagtca      120

tcctaacaga aaagttccag ccaaagagga agctaatgct gtgcctctct gtagagcaaa      180

accctccccc agctatatta atcttcaagc aagttcccca ccagccactt ttctgaacat      240

ccagacaaca aagctgccct cggttgatca caagcccaag gaatgcctag gactcctgga      300

atgtatgtat gcaaacctcc agcttcagac ccagctcgcc caacaacaga tggctgtttt      360

ggaacattta caggcatctg tgacacaact ggctcctggg aggggaagca ataactcttc      420

tctcccagcc ttatctccta atccattgtt aaatcacctg ccccaattca gtaaatgaat      480

tgtggaacaa a                                                           491


<210> 1633
<211> 448
<212> DNA
<213> Homo sapiens

<400> 1633
gtgctggggt tgcggctttc ggttaacacc gcaggcacca cacctgttgg tgttcagatg       60

gagcggcaca ctagtcatcc taacagaaaa gttccagcca aagaggaagc taatgctgtg      120

cctctctgta gagcaaaacc ctcccccagc tatattaatc ttcaagcaag ttccccacca      180

gccacttttc tgaacatcca gacaacaaag ctgccctcgg ttgatcacaa gcccaaggaa      240

tgcctaggac tcctggaatg tatgtatgca aacctccagc ttcagaccca gctcgcccaa      300

caacagatgg ctgttttgga acatttacag gcatctgtga cacaactggc tcctgggagg      360

ggaagcaata actcttctct cccagcctta tctcctaatc cattgttaaa tcacctgccc      420

caattcagta aatgaattgt ggaacaaa                                         448


<210> 1634
<211> 598
<212> DNA
<213> Homo sapiens

<400> 1634
ggcagttggc cagcacacca ctacgcatgt gtgtcaactc tagggttggg tgctggggtt       60

gcggctttcg gttaacaccg cagattggaa caggctgaga tctgctggag acaacttagg      120

aaattatcat agtgaaaata ctaacatgga ttgttgatca tctgatgcta tgattctttc      180

ccaggcacca cacctgttgg tgttcagatg gagcggcaca ctagtcatcc taacagaaaa      240

gttccagcca aagaggaagc taatgctgtg cctctctgta gagcaaaacc ctcccccagc      300

tatattaatc ttcaagcaag ttccccacca gccacttttc tgaacatcca gacaacaaag      360

ctgccctcgg ttgatcacaa gcccaaggaa tgcctaggac tcctggaatg tatgtatgca      420

aacctccagc ttcagaccca gctcgcccaa caacagatgg ctgttttgga acatttacag      480

gcatctgtga cacaactggc tcctgggagg ggaagcaata actcttctct cccagcctta      540

tctcctaatc cattgttaaa tcacctgccc caattcagta aatgaattgt ggaacaaa        598


<210> 1635
<211> 751
<212> DNA
<213> Homo sapiens

<400> 1635
aggaggatcg cttgaacctg ggaggcagag gttgcagtga acagagatcg cgccactgca       60

acccagcctg ggtgacagag cgagactttg tctcaaaata taaaaagaaa aaaaataagg      120

gatcttccaa aaggaaaagg tgaccagtcg agaaatctgg gaaaacccaa ctggttagtg      180

ggaaagagta caacgccggg gacacggagg gaacgattac atctaagatc agtgagattg      240

gaacaggctg agatctgctg gagacaactt aggaaattat catagtgaaa atactaacat      300

ggattgttga tcatctgatg ctatgattct ttcccaggca ccacacctgt tggtgttcag      360

atggagcggc acactagtca tcctaacaga aaagttccag ccaaagagga agctaatgct      420

gtgcctctct gtagagcaaa accctccccc agctatatta atcttcaagc aagttcccca      480

ccagccactt ttctgaacat ccagacaaca aagctgccct cggttgatca caagcccaag      540

gaatgcctag gactcctgga atgtatgtat gcaaacctcc agcttcagac ccagctcgcc      600

caacaacaga tggctgtttt ggaacattta caggcatctg tgacacaact ggctcctggg      660

aggggaagca ataactcttc tctcccagcc ttatctccta atccattgtt aaatcacctg      720

ccccaattca gtaaatgaat tgtggaacaa a                                     751


<210> 1636
<211> 884
<212> DNA
<213> Homo sapiens

<400> 1636
caacttcaac atggccgaag caagtagcgc caatctaggc agcggctgtg aggaaaaaag       60

gcatgagggg tcgtcttcgg aatctgtgcc acccggcact accatttcga gggtgaagct      120

cctcgacacc atggtggaca cttttcttca gaagctggtc gccgccggca gctctccact      180

ccttcattgg gacggaagtg ctggtccccg cctgccctct ggtggacagt ctgtgaaaca      240

ggccttcagt tgggcggcgt gcaggttacc acaggggagg aaggaggaaa tctctgacat      300

caaagaggag gggaacctag aagctgtctt gaatgccttg gataaaattg tggaagaagg      360

caaagtccgc aaagagccag cctggcgccc cagcgggatc ccagagaagg atctgcacag      420

tgttatggca ccctacttcc tgcagcaacg ggacaccctg cggcgccatg tgcagaaaca      480

ggaggccgag aaccagcagc tggcagatgc cgtcctggca gggcggaggc aggtggagga      540

gctgcagcta caggtccagg cccagcagca ggcctggcag gctctacaca gagaacagag      600

ggagctggtt gctgtgctga gggagcctga gtgaggagac cgccagcccc agaagcagag      660

ggcagtcaag gtcaagagcc tgtggtccag catgcctggc ctgggcgggc tacctctgag      720

aacggctgaa atggtgccca gtccatcagc agtgatggaa tttgctggag gactaggcca      780

gagcaagcct cactgccact gtgcctttgg ggcacccttg gggttggaca tacaccccct      840

ttagattcct ctgtttcttc tacctggata attcttggcc atgt                       884


<210> 1637
<211> 1068
<212> DNA
<213> Homo sapiens

<400> 1637
aacttcaaca tggccgaagc aagtagcgcc aatctaggca gcggctgtga ggaaaaaagg       60

catgaggggt cgtcttcgga atctgtgcca cccggcacta ccatttcgag ggtgaagctc      120

ctcgacacca tggtggacac ttttcttcag aagctggtcg ccgccggcag ctaccagaga      180

ttcactgact gctataagtg cttctaccag ttgcagcctg cgatgacaca gcaaatctat      240

gacaagttta tagctcagtt gcagacatct atccgggagg aaatctctga catcaaagag      300

gaggggaacc tagaagctgt cttgaatgcc ttggataaaa ttgtggaaga aggcaaagtc      360

cgcaaagagc cagcctggcg ccccagcggg atcccagaga aggatctgca cagtgttatg      420

gcaccctact tcctgcagca acgggacacc ctgcggcgcc atgtgcagaa acaggaggcc      480

gagaaccagc agctggcaga tgccgtcctg gcagggcgga ggcaggtgga ggagctgcag      540

ctacaggtcc aggcccagca gcaggcctgg caggctctac acagagaaca gagggagctg      600

gttgctgtgc tgagggagcc tgagtgagga gaccgccagc cccagaagca gagggcagtc      660

aaggtcaaga gcctgtggtc cagcatgcct ggcctgggcg ggctacctct gagaacggct      720

gaaatggtgc ccagtccatc agcagtgatg gaatttgctg gaggactagg ccagagcaag      780

cctcactgcc actgtgcctt tggggcaccc ttggggttgg acatacaccc cctttagatt      840

cctctgtttc ttctacctgg ataattcttg gccatgttct ctcttctcta ggttcaggtc      900

agctctgccc ctccgccccc ctcctgctgg ttccccagcc cttttccctg gccctggctt      960

ggagaatctg ttttcaatct ccactgattg cccccttgct ggccagccca ggggccttta     1020

ccatgttctc tccacatccg taaataaact tccttcacta cactgtaa                  1068


<210> 1638
<211> 1019
<212> DNA
<213> Homo sapiens

<400> 1638
agatttggag gttcaacttc aacatggccg aagcaagtag cgccaatcta ggcagcggct       60

gtgaggaaaa aaggcatgag gggtcgtctt cggaatctgt gccacccggc actaccattt      120

cgagggtgaa gctcctcgac accatggtgg acacttttct tcagaagctg gtcgccgccg      180

gcagctacca gagattcact gactgctata agtgcttcta ccagttgcag cctgcgatga      240

cacagcaaat ctatgacaag tttatagctc agttgcagac atctatccgg gaggaaatct      300

ctgacatcaa agaggagggg aacctagaag ctgtcttgaa tgccttggat aaaattgtgg      360

aagaaggcaa agtccgcaaa gagccagcct gcaacgggac accctgcggc gccatgtgca      420

gaaacaggag gccgagaacc agcagctggc agatgccgtc ctggcagggc ggaggcaggt      480

ggaggagctg cagctacagg tccaggccca gcagcaggcc tggcaggctc tacacagaga      540

acagagggag ctggttgctg tgctgaggga gcctgagtga ggagaccgcc agccccagaa      600

gcagagggca gtcaaggtca agagcctgtg gtccagcatg cctggcctgg gcgggctacc      660

tctgagaacg gctgaaatgg tgcccagtcc atcagcagtg atggaatttg ctggaggact      720

aggccagagc aagcctcact gccactgtgc ctttggggca cccttggggt tggacataca      780

ccccctttag attcctctgt ttcttctacc tggataattc ttggccatgt tctctcttct      840

ctaggttcag gtcagctctg cccctccgcc cccctcctgc tggttcccca gcccttttcc      900

ctggccctgg cttggagaat ctgttttcaa tctccactga ttgccccctt gctggccagc      960

ccaggggcct ttaccatgtt ctctccacat ccgtaaataa acttccttca ctacactgt      1019


<210> 1639
<211> 2555
<212> DNA
<213> Homo sapiens

<400> 1639
cctcgatccc ctcgccgcgg tcccatggag gaggaggcga gccgcagcgc cgcggcgacg       60

aacccaggga gaaaaggaag caaatgagct gatggaagat ctgtttgaaa ctttccaaga      120

tgagatggga ttctccaaca tggaagatga tggcccagaa gaggaggagc gtgtggctga      180

gcctcaagct aactttaaca cccctcaagc tctacggttt gaggaactac tggccaacct      240

actaaatgaa caacatcaga tagcgaagga actatttgaa cagctgaaga tgaagaaacc      300

ttcagccaaa cagcagaagg aggtagagaa ggttaaaccc cagtgtaagg aagttcatca      360

gaccctgatt ctggacccag cacaaaggaa gagactccag cagcagatgc agcagcatgt      420

tcagctcttg acacaaatcc accttcttgc cacctgcaac cccaatctca atccggaggc      480

cagtagcacc aggatatgtc ttaaagagct gggaaccttt gctcaaagct ccatcgccct      540

tcaccatcag tacaacccca agtttcagac cctgttccaa ccctgtaact tgatgggagc      600

tatgcagctg attgaagact tcagcacaca tgtcagcatt gactgcagcc ctcataaaac      660

tgtcaagaag actgccaatg aatttccctg tttgccaaag caagtggctt ggatcctggc      720

cacaagcaag gttttcatgt atccagagtt acttccagtg tgttccctga aggcaaagaa      780

tccccaggat aagatcctct tcaccaaggc tgaggacaat ttgttagctt taggactgaa      840

gcattttgaa gggactgagt ttcttaaccc tctaatcagc aagtaccttc taacctgcaa      900

gactgcccgc caactgacag tgagaatcaa gaacctcaac atgaacagag ctcctgacaa      960

catcattaaa ttttataaga agaccaaaca gctgccagtc ctaggaaaat gctgtgaaga     1020

gatccagcca catcagtgga agccacctat agagagagaa gaacaccggc tcccattctg     1080

gttaaaggcc agtctgccat ccatccagga agaactgcgg cacatggctg atggtgctag     1140

agaggtagga aatatgactg gaaccactga gatcaactca gatcaaggcc tagaaaaaga     1200

caactcagag ttggggagtg aaactcggta cccactgcta ttgcctaagg gtgtagtcct     1260

gaaactgaag ccagttgccg accgtttccc caagaaggct tggagacaga agcgttcatc     1320

agtcctgaaa cccctcctta tccaacccag cccctctctc cagcccagct tcaaccctgg     1380

gaaaacacca gcccaatcaa ctcattcaga agcccctccg agcaaaatgg tgctccggat     1440

tcctcaccca atacagccag ccactgtttt acagacagtt ccaggtgtcc ctccactggg     1500

ggtcagtgga ggtgagagtt ttgagtctcc tgcagcactg cctgctatgc cccctgaggc     1560

caggacaagc ttccctctgt ctgagtccca gactttgctc tcttctgccc ctgtgcccaa     1620

ggtaatgatg ccctcccctg cctcttccat gtttcgaaag ccatatgtga gacggagacc     1680

ctcaaaaaga aggggagcca gggcctttcg ctgtatcaaa cctgcccctg ttatccaccc     1740

tgcatctgtt atcttcactg ttcctgctac cactgtgaag attgtgagcc ttggcggtgg     1800

ctgtaacatg atccagcctg tcaatgcggc tgtggcccag agtccccaga ctattcccat     1860

cgccaccctc ttggttaacc ctacttcctt cccctgtcca ttgaaccagc cccttgtggc     1920

ctcctctgtc tcacccttaa ttgtttctgg caattctgtg aatcttccta taccatccac     1980

ccctgaagat aaggcccaca tgaatgtgga cattgcttgt gctgtggctg atggggaaaa     2040

tgcctttcag ggcctagaac ccaaattaga gccccaggaa ctatctcctc tctctgctac     2100

tgttttcccc aaagtggaac atagcccagg gcctccacca gtcgataaac agtgccaaga     2160

aggattgtca gagaacagtg cctatcgctg gaccgttgtg aaaacagagg agggaaggca     2220

agctctggag ccgctccctc agggcatcca ggagtctcta aacaactctt cccctgggga     2280

tttagaggaa gttgtcaaga tggaacctga agatgctaca gaggaaatca gtggatttct     2340

ttgagctagg agaataagag tctggagact gggagccttc acttcggcct ccgattggtg     2400

gcgcataggg tgtaaccaat aggaaacccc taaagggtac ttaaacccca gattttgcaa     2460

ctggggctct tgagcagctt gctttagcct gctcccactc tgtggaatat acttttgctt     2520

caataaatct gtgcttttat tgcttcattg tttca                                2555


<210> 1640
<211> 2874
<212> DNA
<213> Homo sapiens

<400> 1640
gctacatggc cggagtcggg cgaagcgggg gaccgtgggg aagaacgcga ggagggagga       60

gtgggaggtt gggggtgtcg ctaggcgccc ttagctccct ccctctggag gagctgccgc      120

ggccactctg ctgccgccgc tgccgccgcc attttgggtt cgctttgcga ggggaaacga      180

tcccagtgtc ggttgcggga tccgcctcct ctcagtttgc ccctttagcc ctccaccttt      240

cccttctcct ctctcgcatt tccgccagtc ggcttacccg ctggccgcct cctgacaagc      300

gggagggatc cgcggtggac ccagggaagc ggaggagcct ggcggccacc ccctcttcct      360

cacttccctg tactctcatc gctctcggcc tccgacacga aaaggaagca aatgagctga      420

tggaagatct gtttgaaact ttccaagatg agatgggatt ctccaacatg gaagatgatg      480

gcccagaaga ggaggagcgt gtggctgagc ctcaagctaa ctttaacacc cctcaagctc      540

tacggtttga ggaactactg gccaacctac taaatgaaca acatcagata gcgaaggaac      600

tatttgaaca gctgaagatg aagaaacctt cagccaaaca gcagaaggag gtagagaagg      660

ttaaacccca gtgtaaggaa gttcatcaga ccctgattct ggacccagca caaaggaaga      720

gactccagca gcagatgcag cagcatgttc agctcttgac acaaatccac cttcttgcca      780

cctgcaaccc caatctcaat ccggaggcca gtagcaccag gatatgtctt aaagagctgg      840

gaacctttgc tcaaagctcc atcgcccttc accatcagta caaccccaag tttcagaccc      900

tgttccaacc ctgtaacttg atgggagcta tgcagctgat tgaagacttc agcacacatg      960

tcagcattga ctgcagccct cataaaactg tcaagaagac tgccaatgaa tttccctgtt     1020

tgccaaagca agtggcttgg atcctggcca caagcaaggt tttcatgtat ccagagttac     1080

ttccagtgtg ttccctgaag gcaaagaatc cccaggataa gatcctcttc accaaggctg     1140

aggacaattt gttagcttta ggactgaagc attttgaagg gactgagttt cttaaccctc     1200

taatcagcaa gtaccttcta acctgcaaga ctgcccgcca actgacagtg agaatcaaga     1260

acctcaacat gaacagagct cctgacaaca tcattaaatt ttataagaag accaaacagc     1320

tgccagtcct aggaaaatgc tgtgaagaga tccagccaca tcagtggaag ccacctatag     1380

agagagaaga acaccggctc ccattctggt taaaggccag tctgccatcc atccaggaag     1440

aactgcggca catggctgat ggtgctagag aggtaggaaa tatgactgga accactgaga     1500

tcaactcaga tcaaggccta gaaaaagaca actcagagtt ggggagtgaa actcggtacc     1560

cactgctatt gcctaagggt gtagtcctga aactgaagcc agttgccgac cgtttcccca     1620

agaaggcttg gagacagaag cgttcatcag tcctgaaacc cctccttatc caacccagcc     1680

cctctctcca gcccagcttc aaccctggga aaacaccagc ccaatcaact cattcagaag     1740

cccctccgag caaaatggtg ctccggattc ctcacccaat acagccagcc actgttttac     1800

agacagttcc aggtgtccct ccactggggg tcagtggagg tgagagtttt gagtctcctg     1860

cagcactgcc tgctatgccc cctgaggcca ggacaagctt ccctctgtct gagtcccaga     1920

ctttgctctc ttctgcccct gtgcccaagg taatgatgcc ctcccctgcc tcttccatgt     1980

ttcgaaagcc atatgtgaga cggagaccct caaaaagaag gggagccagg gcctttcgct     2040

gtatcaaacc tgcccctgtt atccaccctg catctgttat cttcactgtt cctgctacca     2100

ctgtgaagat tgtgagcctt ggcggtggct gtaacatgat ccagcctgtc aatgcggctg     2160

tggcccagag tccccagact attcccatcg ccaccctctt ggttaaccct acttccttcc     2220

cctgtccatt gaaccagccc cttgtggcct cctctgtctc acccttaatt gtttctggca     2280

attctgtgaa tcttcctata ccatccaccc ctgaagataa ggcccacatg aatgtggaca     2340

ttgcttgtgc tgtggctgat ggggaaaatg cctttcaggg cctagaaccc aaattagagc     2400

cccaggaact atctcctctc tctgctactg ttttccccaa agtggaacat agcccagggc     2460

ctccaccagt cgataaacag tgccaagaag gattgtcaga gaacagtgcc tatcgctgga     2520

ccgttgtgaa aacagaggag ggaaggcaag ctctggagcc gctccctcag ggcatccagg     2580

agtctctaaa caactcttcc cctggggatt tagaggaagt tgtcaagatg gaacctgaag     2640

atgctacaga ggaaatcagt ggatttcttt gagctaggag aataagagtc tggagactgg     2700

gagccttcac ttcggcctcc gattggtggc gcatagggtg taaccaatag gaaaccccta     2760

aagggtactt aaaccccaga ttttgcaact ggggctcttg agcagcttgc tttagcctgc     2820

tcccactctg tggaatatac ttttgcttca ataaatctgt gcttttattg cttc           2874


<210> 1641
<211> 2927
<212> DNA
<213> Homo sapiens

<400> 1641
cgcgtacggg atggctggct cgcaggacgg ccgaaggtgg tggttggtgg gagcagccag       60

cgacgagccc gtagacactc gtacgcgtgc gggctgacgt gcgcgctaca tggccggagt      120

cgggcgaagc gggggaccgt ggggaagaac gcgaggaggg aggagtggga ggttgggggt      180

gtcgctaggc gcccttagct ccctccctct ggaggagctg ccgcggccac tctgctgccg      240

ccgctgccgc cgccattttg ggttcgcttt gcgaggggaa acgatcccag tgtcggttgc      300

gggatccgcc tcctctcagt ttgccccttt agccctccac ctttcccttc tcctctctcg      360

catttccgcc agtcggctta cccgctggcc gcctcctgac aagcgggagg gatccgcggt      420

ggacccaggg aagcggagga gcctggcggc caccccctct tcctcacttc cctgtactct      480

catcgctctc ggcctccgac acgaaaagga agcaaatgag ctgatggaag atctgtttga      540

aactttccaa gatgagatgg gattctccaa catggaagat gatggcccag aagaggagga      600

gcgtgtggct gagcctcaag ctaactttaa cacccctcaa gctctacggt ttgaggaact      660

actggccaac ctactaaatg aacaacatca gatagcgaag gaactatttg aacagctgaa      720

gatgaagaaa ccttcagcca aacagcagaa ggaggtagag aaggttaaac cccagtgtaa      780

ggaagttcat cagaccctga ttctggaccc agcacaaagg aagagactcc agcagcagat      840

gcagcagcat gttcagctct tgacacaaat ccaccttctt gccacctgca accccaatct      900

caatccggag gccagtagca ccaggatatg tcttaaagag ctgggaacct ttgctcaaag      960

ctccatcgcc cttcaccatc agtacaaccc caagtttcag accctgttcc aaccctgtaa     1020

cttgatggga gctatgcagc tgattgaaga cttcagcaca catgtcagca ttgactgcag     1080

ccctcataaa actgtcaaga agactgccaa tgaatttccc tgtttgccaa agcaagtggc     1140

ttggatcctg gccacaagca aggttttcat gtatccagag ttacttccag tgtgttccct     1200

gaaggcaaag aatccccagg ataagatcct cttcaccaag gctgaggaca acaagtacct     1260

tctaacctgc aagactgccc gccaactgac agtgagaatc aagaacctca acatgaacag     1320

agctcctgac aacatcatta aattttataa gaagaccaaa cagctgccag tcctaggaaa     1380

atgctgtgaa gagatccagc cacatcagtg gaagccacct atagagagag aagaacaccg     1440

gctcccattc tggttaaagg ccagtctgcc atccatccag gaagaactgc ggcacatggc     1500

tgatggtgct agagaggtag gaaatatgac tggaaccact gagatcaact cagatcaagg     1560

cctagaaaaa gacaactcag agttggggag tgaaactcgg tacccactgc tattgcctaa     1620

gggtgtagtc ctgaaactga agccagttgc cgaccgtttc cccaagaagg cttggagaca     1680

gaagcgttca tcagtcctga aacccctcct tatccaaccc agcccctctc tccagcccag     1740

cttcaaccct gggaaaacac cagcccaatc aactcattca gaagcccctc cgagcaaaat     1800

ggtgctccgg attcctcacc caatacagcc agccactgtt ttacagacag ttccaggtgt     1860

ccctccactg ggggtcagtg gaggtgagag ttttgagtct cctgcagcac tgcctgctat     1920

gccccctgag gccaggacaa gcttccctct gtctgagtcc cagactttgc tctcttctgc     1980

ccctgtgccc aaggtaatga tgccctcccc tgcctcttcc atgtttcgaa agccatatgt     2040

gagacggaga ccctcaaaaa gaaggggagc cagggccttt cgctgtatca aacctgcccc     2100

tgttatccac cctgcatctg ttatcttcac tgttcctgct accactgtga agattgtgag     2160

ccttggcggt ggctgtaaca tgatccagcc tgtcaatgcg gctgtggccc agagtcccca     2220

gactattccc atcgccaccc tcttggttaa ccctacttcc ttcccctgtc cattgaacca     2280

gccccttgtg gcctcctctg tctcaccctt aattgtttct ggcaattctg tgaatcttcc     2340

tataccatcc acccctgaag ataaggccca catgaatgtg gacattgctt gtgctgtggc     2400

tgatggggaa aatgcctttc agggcctaga acccaaatta gagccccagg aactatctcc     2460

tctctctgct actgttttcc ccaaagtgga acatagccca gggcctccac cagtcgataa     2520

acagtgccaa gaaggattgt cagagaacag tgcctatcgc tggaccgttg tgaaaacaga     2580

ggagggaagg caagctctgg agccgctccc tcagggcatc caggagtctc taaacaactc     2640

ttcccctggg gatttagagg aagttgtcaa gatggaacct gaagatgcta cagaggaaat     2700

cagtggattt ctttgagcta ggagaataag agtctggaga ctgggagcct tcacttcggc     2760

ctccgattgg tggcgcatag ggtgtaacca ataggaaacc cctaaagggt acttaaaccc     2820

cagattttgc aactggggct cttgagcagc ttgctttagc ctgctcccac tctgtggaat     2880

atacttttgc ttcaataaat ctgtgctttt attgcttcat tgtttca                   2927


<210> 1642
<211> 2245
<212> DNA
<213> Homo sapiens

<400> 1642
agcgcagtat ggcgggcggg gcccgggagg tgctcacact gcagttggga cattttgccg       60

gtttcgtggg cgcgcactgg tggaaccagc aggatgctgc gctgggccga gcgaccgatt      120

ccaaggagcc cccgggagag ctgtgccccg acgtcctgta tcgtacgggc cggacgctgc      180

acggccagga gacctacacg ccgcgactca tcctcatgga tctgaagggt agtttgagct      240

ccctaaaaga ggaaggtgga ctctacaggg acaaacagtt ggatgctgca atagcatggc      300

aggggaagct caccacacac aaaggttcct caccactccc caccgctaca actccaaaac      360

cacttatccc tacagaggcc agcatcaggg tctggtcaga cttcctcaga gtccatctcc      420

atccccggag catctgtatg attcagaagt acaaccacga tggggaagca ggtcggctgg      480

aggcttttgg ccaaggggaa agtgtcctaa aggaacccaa gtaccaggaa gagctggagg      540

acaggctgca tttctacgtg gaggaatgtg actacttgca gggcttccag atcctgtgtg      600

acctgcacga tggcttctct ggggtaggcg cgaaggcggc agagctgcta caagatgaat      660

attcagggcg gggaataata acctggggcc tgctacctgg tccctaccat cgtggggagg      720

cccagagaaa catctatcgt ctattaaaca cagcttttgg tctcgtgcac ctgactgctc      780

acagctctct tgtctgcccc ttgtccttgg gtgggagcct gggcctgcga cccgagccac      840

ctgtcagctt cccttacctg cattatgatg ccactctgcc cttccactgc agtgccatcc      900

tggctacagc cctggacaca gtcactgttc cttatcgcct gtgttcctct ccagtttcca      960

tggttcatct ggctgacatg ctgagcttct gtgggaaaaa ggtggtgaca gcaggagcaa     1020

tcatcccttt ccccttggct ccaggccagt cccttcctga ttccctgatg cagtttggag     1080

gagccacccc atggacccca ctgtctgcat gtggggagcc ttctggaaca cgttgctttg     1140

cccagtcagt ggtgctgagg ggtatagaca gagcatgcca cacaagccag ctcaccccag     1200

ggacacctcc accctctgcc cttcatgcat gtaccactgg ggaagaaatc ttggctcagt     1260

atttacaaca gcagcagcct ggagtcatga gttcttccca tctgctgctg actccctgca     1320

gggtggctcc tccttacccc cacctcttct caagctgcag tccaccggca gtggagagca     1380

tcccagtgtt tggggcactg tgttcctctt cgtccctgca ccagaccctg gaagccttgg     1440

ccagagacct caccaaactc gacttgcggc gctgggccag cttcatggat gctggagtgg     1500

agcacgatga cgtagcagag ctgctgcagg agctacaaag cctggcccag tgctaccagg     1560

gtggtgacag cctcgtggac taaagttccc agtgtgggag aaaggagcta gtttgcaata     1620

aaaacagctg gatgcaggag cccagtgtct tcatgcagag gagctcaatg tcgcgggact     1680

agctacacca acatatgcac tttttacatt tagaaacact gtgattagac cacagaacaa     1740

taaatatgtg ccatcagacc aaaaaaaagt agagaaagga gctgaactcc actctcgatg     1800

ctacttacag aggacatctg taaagtcttc ataaaagacc ttgaatgatg cctaggatgg     1860

cagagcccct gggtcctact ccatcctcca gcctttgtcc ttgtcctggc ctcctgctct     1920

ccagatctgt aaactgggct caaggactgt acaagcagag tacaactacc cgcctccccg     1980

gtgccagggc gcctgttggg tttggtcctg tgtagatgat tcccagagtc tcattcatcc     2040

agctcctctt cagacagaag gtccccatgg tcagacagct ggtctgcatt gctggtactg     2100

gttgcatcat cctcatcctc agagctggct tcacaggcag tgtggaagag ctgcatgagt     2160

tctcgaaaat ggtgggaaac ctaagaaagg aggagggctg tattcactga tccttagtaa     2220

catgttaaca tttatgaagc actat                                           2245


<210> 1643
<211> 2503
<212> DNA
<213> Homo sapiens

<400> 1643
gccgactcca agcaagtttg tcggccttgg ggagtctggc cccgttccta gtgctggagg       60

gggaagttgt tgcctttcct gctccgtggg ccggccccct ctccctccag acccacctgg      120

gcatagtgga cgcgggctta cccagcctcc atgccaagtc tagggggtcc cagcgagtct      180

gttgttaggg gctttgggtc acaccctctg tggaattcct tggcctgtgc agctcgggcc      240

tgccccccga ccttgctagg gaggggtgga gggtgaagct cccgggagct cattggcact      300

agaggttctg gccacgccct ctccgcgagt ccagtcccac gcgggatgaa gagggcaccc      360

tccgccaaga ggctgctgcg ggacccgggt ttcccctttc cggcgccttc cagcctccca      420

atcctcgggt ctcgcctccc tccgtctcct ccctttcccc tgtctgtctt tccattggtc      480

catgccgccc acgtgctccc cggggctccg caggcaggac tgggccccgg ggcggtgcgc      540

tgggctacac ctccctcccc gcgccccgtc ctctcccgcc ctacaggccc tagcagggca      600

ggcgggagtc cgtagttcgt ggtccttcgc cggtgtcccc ggagcccagc ggctgtggat      660

ggcagaagcc cagagtggga ctggtcagct gcaggagcag aagaaaggtc ttctgatagc      720

cgtcagcgtc tccgttgata aaatcatctc gcatttcggg gccgcccgga acttggtgca      780

gaaggcccag ttgggtgata gccggctgag cccggatgtg gggcacctgg tgctgaccac      840

cctctgcccg gccctccacg ccctggtggc ggacgggctg aagcctttcc ggaaggacct      900

catcaccggg cagcgcagga gcagcccctg gagcgtggtg gaggcgtcgg tgaagccagg      960

ctccagcacc cgctcccttg gaaccctgta tagccaggtc agccgtctag ccccgctgag     1020

cagcagccgt agccgcttcc atgcctttat cctgggcctc ctcaacacca agcagttgga     1080

gctgtggttt tccagtctcc aggaagatgc aggcctgctc tccctcctgt acctgccaac     1140

aggatttttc tccctggccc gcggtggttg tccctccctg tccacagagc tgctgctcct     1200

gctgcagcca ttgtcggtgc tcactttcca cctggacctg ctctttgagc accaccacca     1260

cctgcccctg ggcccacctc aggcccctgc ccctccaggc ccacctccag ctctgcagca     1320

gactatgcaa gccatgctgc actttggggg ccggctggcc cagagccttc gggggacttc     1380

caaggaagct gcttcagacc cctctgactc tccaaacctt cccacaccag ggagctggtg     1440

ggagcagttg acccaggcct cccgggtcta tgcctctggg ggcactgagg gctttcctct     1500

ttcccgatgg gcaccggggc gtcatgggac tgcagctgaa gaaggtgcac aggagagacc     1560

cctgcccaca gatgagatgg caccaggcag gggcctctgg ttgggaagac tatttggagt     1620

gcctgggggc cccgcagaaa atgagaatgg agccctaaag tccaggagac catctagctg     1680

gctgcccccg acagtgagtg tgttggctct tgtgaagcgg ggggcacctc ccgagatgcc     1740

ttctcctcag gagcttgagg cctcagcacc caggatggtg caaacccata gggcagtgcg     1800

ggctctctgt gatcacactg ctgcaagacc tgaccagttg agcttccggc gtggggaagt     1860

gctgcgtgtc atcaccacag tggatgagga ctggctccgc tgtgggcggg atggcatgga     1920

gggtctggtg cctgtggggt atacctccct tgttctgtag ccctgggacc ctttcctgcg     1980

tatgtgtctc cttcctgtca cctgggaatg gaatggccag tgaacaccat cccagaagca     2040

ttttccctct gcaaaatgac gtttcttccc acgtctgttt ctgctaatat ttaaaataaa     2100

ctttccttct tccctcctat acccacctgt aaggtgaaat ctgctcttct tccaaatata     2160

taaaaaagga attgccctcc aggtaatccc tttccttttt cccgtctata taagggaatg     2220

tcttccttcc tatctatctg caaaatggaa atctagacct ccttcttcat ccataagtgg     2280

actgtgccag tacaatacat gcctcagccc ccaagcctag aaggacctct agtctccttc     2340

ctgtgtggaa tcttccccac tccatccctc ccaagttgcc tgtattgata atgtactcac     2400

tcatgctgta ctaggtgctg aagcctggac acccttggtg ggtgggcctg tggtgatggt     2460

ttgcatcctt cctcctttgt cccaataaag tatgggagtt gaa                       2503


<210> 1644
<211> 1968
<212> DNA
<213> Homo sapiens

<400> 1644
cgccctacag gccctagcag ggcaggcggg aggtgagcgc ggccatcccg ctcccggagt       60

tccgggatcc tggagtccgt agttcgtggt ccttcgccgg tgtccccgga gcccagcggc      120

tgtggatggc agaagcccag agtgggactg gtcagctgca ggagcagaag aaaggtcttc      180

tgatagccgt cagcgtctcc gttgataaaa tcatctcgca tttcggggcc gcccggaact      240

tggtgcagaa ggcccagttg ggtgatagcc ggctgagccc ggatgtgggg cacctggtgc      300

tgaccaccct ctgcccggcc ctccacgccc tggtggcgga cgggctgaag cctttccgga      360

aggacctcat caccgggcag cgcaggagca gcccctggag cgtggtggag gcgtcggtga      420

agccaggctc cagcacccgc tcccttggaa ccctgtatag ccaggtcagc cgtctagccc      480

cgctgagcag cagccgtagc cgcttccatg cctttatcct gggcctcctc aacaccaagc      540

agttggagct gtggttttcc agtctccagg aagatgcagg cctgctctcc ctcctgtacc      600

tgccaacagg atttttctcc ctggcccgcg gtggttgtcc ctccctgtcc acagagctgc      660

tgctcctgct gcagccattg tcggtgctca ctttccacct ggacctgctc tttgagcacc      720

accaccacct gcccctgggc ccacctcagg cccctgcccc tccaggccca cctccagctc      780

tgcagcagac tatgcaagcc atgctgcact ttgggggccg gctggcccag agccttcggg      840

ggacttccaa ggaagctgct tcagacccct ctgactctcc aaaccttccc acaccaggga      900

gctggtggga gcagttgacc caggcctccc gggtctatgc ctctgggggc actgagggct      960

ttcctctttc ccgatgggca ccggggcgtc atgggactgc agctgaagaa ggtgcacagg     1020

agagacccct gcccacagat gagatggcac caggcagggg cctctggttg ggaagactat     1080

ttggagtgcc tgggggcccc gcagaaaatg agaatggagc cctaaagtcc aggagaccat     1140

ctagctggct gcccccgaca gtgagtgtgt tggctcttgt gaagcggggg gcacctcccg     1200

agatgccttc tcctcaggag cttgaggcct cagcacccag gatggtgcaa acccataggg     1260

cagtgcgggc tctctgtgat cacactgctg caagacctga ccagttgagc ttccggcgtg     1320

gggaagtgct gcgtgtcatc accacagtgg atgaggactg gctccgctgt gggcgggatg     1380

gcatggaggg tctggtgcct gtggggtata cctcccttgt tctgtagccc tgggaccctt     1440

tcctgcgtat gtgtctcctt cctgtcacct gggaatggaa tggccagtga acaccatccc     1500

agaagcattt tccctctgca aaatgacgtt tcttcccacg tctgtttctg ctaatattta     1560

aaataaactt tccttcttcc ctcctatacc cacctgtaag gtgaaatctg ctcttcttcc     1620

aaatatataa aaaaggaatt gccctccagg taatcccttt cctttttccc gtctatataa     1680

gggaatgtct tccttcctat ctatctgcaa aatggaaatc tagacctcct tcttcatcca     1740

taagtggact gtgccagtac aatacatgcc tcagccccca agcctagaag gacctctagt     1800

ctccttcctg tgtggaatct tccccactcc atccctccca agttgcctgt attgataatg     1860

tactcactca tgctgtacta ggtgctgaag cctggacacc cttggtgggt gggcctgtgg     1920

tgatggtttg catccttcct cctttgtccc aataaagtat gggagttg                  1968


<210> 1645
<211> 3403
<212> DNA
<213> Homo sapiens

<400> 1645
cgccgggcgg ggaccgtggg agccgcggac aagcccaagg ccggagcggt tccaggagga       60

ccctggtctg cacctgtggt tgccaggtag gtggatgtga gagaccctac ccttctggtt      120

ctctagaagc catcccatcg ccgctagcat catgctgtcc cctcagagag ctttactctg      180

caacctcaac cacatccacc tccagcacgt ctccctgggc ctgcacttgt cccgccgtcc      240

tgagctacag gaggggcctt tgagcacacc ccctcctcca ggagacactg ggggcaagga      300

gagcaggggc ccctgcagtg gcaccctggt ggacgccaat tccaacagcc cagctgtgcc      360

ctgccggtgc tgccaggagc acggtccggg cctagaaaac cggcaggacc cgtcacagga      420

ggaagagggg gctgcctctc cctcagaccc aggctgctcc tcctcactca gctcctgctc      480

agatcttagc cccgatgagt cccctgtctc agtctacttg cgggacctcc ctggtgatga      540

ggatgcccac cctcagccca gtatcatccc cctggagcag ggctccccac tggcttcagc      600

aggccctggc acctgctcac cggacagctt ctgctgctct cctgattcct gctccggagc      660

ttcttcttca cccgatcctg gcctggactc gaactgcaac gccctgacca cctgccagga      720

cgtcccttcc ccaggcttgg aggaagagga cgagagggcg gagcaggatc tccctacctc      780

tgagctctta gaggcggatg atgggaaaat cgacgctggg aaaacggagc ccagttggaa      840

gattaaccca atttggaaaa ttgacacaga gaaaactaaa gctgaatgga aaaccactga      900

aaacaataac actggttgga aaaacaacgg gaatgttaac tctagctgga aaagtgaacc      960

tgaaaaattc gactctggtt ggaaaaccaa cacaagaata actgattctg gctcgaaaac     1020

agatgcaggg aaaattgatg gaggatggag aagtgacgtc agcgaggagc cggtgcccca     1080

ccggacaatc acgtccttcc acgagctggc ccagaagcgc aagcggggcc cagggctgcc     1140

ccttgtcccg caggcgaaga aagatcgcag tgactggctc atagtcttct cgcccgacac     1200

cgagctcccc ccctcggggt cgccgggcgg ctcctcggca cctcctcggg aagtcaccac     1260

cttcaaggaa ctccggtccc gaagccgggc cccagccccg ccagtcccgc ctcgagaccc     1320

cccagttggc tgggctttgg tcccgccccg gcccccaccc ccgcctgtcc ctccccgaag     1380

gaagaagaac cgacctggac tgcagcccat agcggagggg cagtccgagg agggccgggc     1440

tgtcagccca gcggctggcg aggaggcccc agccgcgaag gagccgggcg cgcaggccgg     1500

cctggaggtc cgtagttcgt ggtccttcgc cggtgtcccc ggagcccagc ggctgtggat     1560

ggcagaagcc cagagtggga ctggtcagct gcaggagcag aagaaaggtc ttctgatagc     1620

cgtcagcgtc tccgttgata aaatcatctc gcatttcggg gccgcccgga acttggtgca     1680

gaaggcccag ttgggtgata gccggctgag cccggatgtg gggcacctgg tgctgaccac     1740

cctctgcccg gccctccacg ccctggtggc ggacgggctg aagcctttcc ggaaggacct     1800

catcaccggg cagcgcagga gcagcccctg gagcgtggtg gaggcgtcgg tgaagccagg     1860

ctccagcacc cgctcccttg gaaccctgta tagccaggtc agccgtctag ccccgctgag     1920

cagcagccgt agccgcttcc atgcctttat cctgggcctc ctcaacacca agcagttgga     1980

gctgtggttt tccagtctcc aggaagatgc aggcctgctc tccctcctgt acctgccaac     2040

aggatttttc tccctggccc gcggtggttg tccctccctg tccacagagc tgctgctcct     2100

gctgcagcca ttgtcggtgc tcactttcca cctggacctg ctctttgagc accaccacca     2160

cctgcccctg ggcccacctc aggcccctgc ccctccaggc ccacctccag ctctgcagca     2220

gactatgcaa gccatgctgc actttggggg ccggctggcc cagagccttc gggggacttc     2280

caaggaagct gcttcagacc cctctgactc tccaaacctt cccacaccag ggagctggtg     2340

ggagcagttg acccaggcct cccgggtcta tgcctctggg ggcactgagg gctttcctct     2400

ttcccgatgg gcaccggggc gtcatgggac tgcagctgaa gaaggtgcac aggagagacc     2460

cctgcccaca gatgagatgg caccaggcag gggcctctgg ttgggaagac tatttggagt     2520

gcctgggggc cccgcagaaa atgagaatgg agccctaaag tccaggagac catctagctg     2580

gctgcccccg acagtgagtg tgttggctct tgtgaagcgg ggggcacctc ccgagatgcc     2640

ttctcctcag gagcttgagg cctcagcacc caggatggtg caaacccata gggcagtgcg     2700

ggctctctgt gatcacactg ctgcaagacc tgaccagttg agcttccggc gtggggaagt     2760

gctgcgtgtc atcaccacag tggatgagga ctggctccgc tgtgggcggg atggcatgga     2820

gggtctggtg cctgtggggt atacctccct tgttctgtag ccctgggacc ctttcctgcg     2880

tatgtgtctc cttcctgtca cctgggaatg gaatggccag tgaacaccat cccagaagca     2940

ttttccctct gcaaaatgac gtttcttccc acgtctgttt ctgctaatat ttaaaataaa     3000

ctttccttct tccctcctat acccacctgt aaggtgaaat ctgctcttct tccaaatata     3060

taaaaaagga attgccctcc aggtaatccc tttccttttt cccgtctata taagggaatg     3120

tcttccttcc tatctatctg caaaatggaa atctagacct ccttcttcat ccataagtgg     3180

actgtgccag tacaatacat gcctcagccc ccaagcctag aaggacctct agtctccttc     3240

ctgtgtggaa tcttccccac tccatccctc ccaagttgcc tgtattgata atgtactcac     3300

tcatgctgta ctaggtgctg aagcctggac acccttggtg ggtgggcctg tggtgatggt     3360

ttgcatcctt cctcctttgt cccaataaag tatgggagtt gaa                       3403


<210> 1646
<211> 3114
<212> DNA
<213> Homo sapiens

<400> 1646
gctagtgccc ctcccctccc gctctgtgcc ccgccgggcg gggaccgtgg gagccgcgga       60

caagcccaag gccggagcgg ttccaggagg accctggtct gcacctgtgg ttgccaggta      120

ggtggatgtg agagacccta cccttctggt tctctagaag ccatcccatc gccgctagca      180

tcatgctgtc ccctcagaga gctttactct gcaacctcaa ccacatccac ctccagcacg      240

tctccctggg cctgcacttg tcccgccgtc ctgagctaca ggaggggcct ttgagcacac      300

cccctcctcc aggagacact gggggcaagg agagcagggg cccctgcagt ggcaccctgg      360

tggacgccaa ttccaacagc ccagctgtgc cctgccggtg ctgccaggag cacggtccgg      420

gcctagaaaa ccggcaggac ccgtcacagg aggaagaggg ggctgcctct ccctcagacc      480

caggctgctc ctcctcactc agctcctgct cagatcttag ccccgatgag tcccctgtct      540

cagtctactt gcgggacctc cctggtgatg aggatgccca ccctcagccc agtatcatcc      600

ccctggagca gggctcccca ctggcttcag caggccctgg cacctgctca ccggacagct      660

tctgctgctc tcctgattcc tgctccggag cttcttcttc acccgatcct ggcctggact      720

cgaactgcaa cgccctgacc acctgccagg acgtcccttc cccaggcttg gaggaagagg      780

acgagagggc ggagcaggat ctccctacct ctgagctctt agaggcggat gatgggaaaa      840

tcgacgctgg gaaaacggag cccagttgga agattaaccc aatttggaaa attgacacag      900

agaaaactaa agctgaatgg aaaaccactg aaaacaataa cactggttgg aaaaacaacg      960

ggaatgttaa ctctagctgg aaaagtgaac ctgaaaaatt cgactctggt tggaaaacca     1020

acacaagaat aactgattct ggctcgaaaa cagatgcagg gaaaattgat ggaggatgga     1080

gaagtgacgt cagcgaggag ccggtgcccc accggacaat cacgtccttc cacgagctgg     1140

cccagaagcg caagcggggc ccagggctgc cccttgtccc gcaggcgaag aaagatcgca     1200

gtgactggct catagtcttc tcgcccgaca ccgagctccc cccctcgggg tcgccgggcg     1260

gctcctcggc acctcctcgg gaagtcacca ccttcaagga actccggtcc cgaagccggg     1320

ccccagcccc gccagtcccg cctcgagacc ccccagttgg ctgggctttg gtcccgcccc     1380

ggcccccacc cccgcctgtc cctccccgaa ggaagaagaa ccgacctgga ctgcagccca     1440

tagcggaggg gcagtccgag gagggccggg ctgtcagccc agcggctggc gaggaggccc     1500

cagccgcgaa ggagccgggc gcgcaggccg gcctggaggt ccgtagttcg tggtccttcg     1560

ccggtgtccc cggagcccag cggctgtgga tggcagaagc ccagagtggg actggtcagc     1620

tgcaggagca gaagaaaggt cttctgatag ccgtcagcgt ctccgttgat aaaatcatct     1680

cgcatttcgg ggccgcccgg aacttggtgc agaaggccca gttgggtgat agccggctga     1740

gcccggatgt ggggcacctg gtgctgacca ccctctgccc ggccctccac gccctggtgg     1800

cggacgggct gaagcctttc cggaaggacc tcatcaccgg gcagcgcagg agcagcccct     1860

ggagcgtggt ggaggcgtcg gtgaagccag gctccagcac ccgctccctt ggaaccctgt     1920

atagccaggt cagccgtcta gccccgctga gcagcagccg tagccgcttc catgccttta     1980

tcctgggcct cctcaacacc aagcagttgg agctgtggtt ttccagtctc caggaagatg     2040

cagggagctg gtgggagcag ttgacccagg cctcccgggt ctatgcctct gggggcactg     2100

agggctttcc tctttcccga tgggcaccgg ggcgtcatgg gactgcagct gaagaaggtg     2160

cacaggagag acccctgccc acagatgaga tggcaccagg caggggcctc tggttgggaa     2220

gactatttgg agtgcctggg ggccccgcag aaaatgagaa tggagcccta aagtccagga     2280

gaccatctag ctggctgccc ccgacagtga gtgtgttggc tcttgtgaag cggggggcac     2340

ctcccgagat gccttctcct caggagcttg aggcctcagc acccaggatg gtgcaaaccc     2400

atagggcagt gcgggctctc tgtgatcaca ctgctgcaag acctgaccag ttgagcttcc     2460

ggcgtgggga agtgctgcgt gtcatcacca cagtggatga ggactggctc cgctgtgggc     2520

gggatggcat ggagggtctg gtgcctgtgg ggtatacctc ccttgttctg tagccctggg     2580

accctttcct gcgtatgtgt ctccttcctg tcacctggga atggaatggc cagtgaacac     2640

catcccagaa gcattttccc tctgcaaaat gacgtttctt cccacgtctg tttctgctaa     2700

tatttaaaat aaactttcct tcttccctcc tatacccacc tgtaaggtga aatctgctct     2760

tcttccaaat atataaaaaa ggaattgccc tccaggtaat ccctttcctt tttcccgtct     2820

atataaggga atgtcttcct tcctatctat ctgcaaaatg gaaatctaga cctccttctt     2880

catccataag tggactgtgc cagtacaata catgcctcag cccccaagcc tagaaggacc     2940

tctagtctcc ttcctgtgtg gaatcttccc cactccatcc ctcccaagtt gcctgtattg     3000

ataatgtact cactcatgct gtactaggtg ctgaagcctg gacacccttg gtgggtgggc     3060

ctgtggtgat ggtttgcatc cttcctcctt tgtcccaata aagtatggga gttg           3114


<210> 1647
<211> 1513
<212> DNA
<213> Homo sapiens

<400> 1647
gaagtggggg aggaggagga ggagttggaa ggggaggagg aagaggggga gcaggaagag       60

gggcagaagg aagaagaaga gggggaggag aaagagatag aagagtaaga ggagggggaa      120

gaaagacaag gggaagggga ggaggaggag gacggggagg agcttcgccg cggcctgctc      180

cgcccagccg gggtcggtgg ccgcatggct tcggtctcct ctgcgacctt ctcgggccac      240

ggggctcggt ccctactgca gttcctgcgg ctggtagggc agctcaagag agtcccacga      300

actggctggg tatacagaaa tgtccagagg ccggagagcg tttcagatca catgtaccgg      360

atggcagtta tggctatggt gatcaaagat gaccgtctta acaaagaccg agaagctatg      420

aagcagataa cccagctcct accagaggac ctcagaaagg agctctatga actttgggaa      480

gagtacgaga cccaatctag tgcagaagcc aaatttgtga agcagctaga ccaatgtgaa      540

atgattcttc aagcatctga atatgaagac cttgaacaca aacctgggag actgcaagac      600

ttctatgatt ccacagcagg aaaattcaat caccctgaga tagtccagct tgtttctgaa      660

cttgaggcag aaagaagcac taacatagct gcagctgcca gtgagccaca ctcctgagac      720

actctctaaa ttgctgcact cctgtaacaa acattatttt tccatttcat tgtattgtgt      780

tttgccattg ttggtctgtt gatttcccta gatgtgagtc tgtttgtttt caattgtctg      840

aacttcagca agaaatgtga tacaacttgg gcactaaaag aagccacaga acaggaagcg      900

gtcatgaaag tgccatggat gaacactgga ggtggcagtg cctgtttatg aactaaataa      960

ataaatatta aacacctaaa atattagaat atttattgga gatttaaaat catcttattc     1020

tgacttaatt accgatatcc ccgaaggcta ggttcattga ataatagaaa atttcattat     1080

gattgctttt aagaacagat tcttcagctg atttagtgat aagaatccag aaaagaaaat     1140

gtactagtga tgtattctct ccccagatga aattgctgcc ttattcagat ttactctctt     1200

gagccagatt ttgaatttca ctgcagactg cttcagactt ctaatcatag gcttgtaaac     1260

ctactaatag gctctgcccc tcttcccaat actttttgtc atttagagat ataaaccggg     1320

gcatataaaa atgcaacttg tattcctttg tatatttttc cctgtctgac ttataaatct     1380

tgagaccttt attgtaaaag catgtatcat caggtgagaa atataaatag gaactggggt     1440

cattgagcct caggtaggga atatatcaac ccgatttctt cctctctttt cccttttata     1500

ggataaataa tcc                                                        1513


<210> 1648
<211> 2147
<212> DNA
<213> Homo sapiens

<400> 1648
aggtaaccag aagcggctag tggcggctgc ctgcgtcccc aaccccctcc gcgcagcgct       60

cgcgacacgc gtgccaggag tgggagcgag cggcggggcc agctgcgttc tgagcctggg      120

cgcagctgcc atctgctctg ggaagcacca gggtgtcccc gccgccctca gctcgaagtc      180

agccaccatg gaggcgcagg cacaaggttt gttggagact gaaccgttgc aaggaacaga      240

cgaagatgca gtagccagtg ctgacttctc tagcatgctc tctgaggagg aaaaggaaga      300

gttaaaagca gagttagttc agctagaaga cgaaattaca acactacgac aagttttgtc      360

agcgaaagaa aggcatctag ttgagataaa acaaaaactc ggcatgaacc tgatgaatga      420

attaaaacag aacttcagca aaagctggca tgacatgcag actaccactg cctacaagaa      480

aacacatgaa accctgagtc acgcagggca aaaggcaact gcagctttca gcaacgttgg      540

aacggccatc agcaagaagt tcggagacat gagacgaaag taggcggtac gaaccctaat      600

ggaggcagtt ttgaggaggt cctcagctcc acggcccatg ccagtgccca gagcttggca      660

ggaggctccc ggcggaccaa ggaggaggag ctgcagtgct aagtccagcc agcgtgcagc      720

tgcatccaga aaccggccac tacccagccc atctctgcct gtgcttatcc agataagaag      780

accaaaatcc cgctgggaaa aacccaggcc ttgacattgt tattcaaatg gcccctccag      840

aaagtttaat gatttccatt tgtatttgtg ttgatgatgg accacttgac catcacattt      900

cagtattcat agatgactgt cacattttaa aatgttccca cttgagcagg tacacaactg      960

gtcataattc ctgtctgtgt aattcgatgt atatttttcc aaacatgtag ctattgtttg     1020

ctttgatttt tgcttggcct cctttatgat gtgcatgtcc ttgaaggctg aatgaacagt     1080

ccctttcagt tcagcagatc aacaggatgg agctcttcat gactgtctcc agcaatagga     1140

tgatttacta taaatttcat ccaactactt gtgatctctc tcacctacat caattatgta     1200

tgttaatttc agcaattaaa agaattgatt ttaatgactt tgaattctta atttctttgt     1260

cttaaaagtt gctagttatg attttacaga tgcaatttta aatcaacttt tagccaggtg     1320

cggcggctca cacctgtaat cccaactatt ttggatgcca aggtgagagg attgcttgag     1380

gccaggagtt aaagatcagc ctgggcaaca cagaccctgt ctctacaaaa aaagaaaaaa     1440

attagccaga catagtgttg cttgcctgta gtcccagcta ctctagaggc tgaggcagga     1500

ggattgcatg agcctaggag ttcgaaactg cagtgagcta tgattgcacc actgcactac     1560

tccagcctgg gtgacagagt gggacactgt ctccaaaaat agtaataata agtagtcaac     1620

ttttactgct aatttggtga acatgagaga ggatatgaaa ataaatatta cctcagctat     1680

cctaggatgt taaaataatc tccaatttta aaattctctc caatctacat acagtagtag     1740

ttagtcagat aaaggatatc caaaaaagag atagctagaa aatgggagaa gcagagttct     1800

gcaacccctt tcagtttgta aattgttcac atgtatgaaa ataactggta tttatcaatc     1860

cactcagatt tctgcactaa cttttatctt atatatcata tgtatctctt ttctttttct     1920

aaatgggaac atatatttgt tattaggtgg cagagatata gccttaagat atatttgtaa     1980

aatgcacact gaatagacat ccaacctaaa aaaaatcact atttaaaaag cccatataat     2040

atatacatat ttgttagcat gctaattgtt catgttttgt gtttattaaa tagaagtgat     2100

atatatgaca ttttgaagta aagcacatct gaaaaattct actcaaa                   2147


<210> 1649
<211> 1308
<212> DNA
<213> Homo sapiens

<400> 1649
ttggtttggg ccaggtggac tggaaggggc ggaggtaacc agaagcggct agtggcggct       60

gcctgcgtcc ccaaccccct ccgcgcagcg ctcgcgacac gcgtgccagg agtgggagcg      120

agcggcgggg ccagctgcgt tctgagcctg ggcgcagctg ccatctgctc tgggaagcac      180

cagggtgtcc ccgccgccct cagctcgaag tcagccacca tggaggcgca ggcacaaggt      240

ttgttggaga ctgaaccgtt gcaaggaaca gacgaagatg cagtagccag tgctgacttc      300

tctagcatgc tctctgagga ggaaaaggaa gagttaaaag cagagttagt tcagctagaa      360

gacgaaatta caacactacg acaagttttg tcagcgaaag aaaggcatct agttgagata      420

aaacaaaaac tcggcatgaa cctgatgaat gaattaaaac agaacttcag caaaagctgg      480

catgacatgc agactaccac tgcctacaag aaaacacatg aaaccctgag tcacgcaggg      540

caaaaggcaa ctgcagcttt cagcaacgtt ggaacggcca tcagcaagaa gttcggagac      600

atgagttact ccattcgcca ttccataagt atgcctgcta tgagacgaaa gtaggcggta      660

cgaaccctaa tggaggcagt tttgaggagg tcctcagctc cacggcccat gccagtgccc      720

agagcttggc aggaggctcc cggcggacca aggaggagga gctgcagtgc taagtccagc      780

cagcgtgcag ctgcatccag aaaccggcca ctacccagcc catctctgcc tgtgcttatc      840

cagataagaa gaccaaaatc ccgctgggaa aaacccaggc cttgacattg ttattcaaat      900

ggcccctcca gaaagtttaa tgatttccat ttgtatttgt gttgatgatg gaccacttga      960

ccatcacatt tcagtattca tagatgactg tcacatttta aaatgttccc acttgagcag     1020

gtacacaact ggtcataatt cctgtctgtg taattcgatg tatatttttc caaacatgta     1080

gctattgttt gctttgattt ttgcttggcc tcctttatga tgtgcatgtc cttgaaggct     1140

gaatgaacag tccctttcag ttcagcagat caacaggatg gagctcttca tgactgtctc     1200

cagcaatagg atgatttact ataaatttca tccaactact tgtgatctct ctcacctaca     1260

tcaattatgt atgttaattt cagcaattaa aagaattgat tttaatga                  1308


<210> 1650
<211> 1175
<212> DNA
<213> Homo sapiens

<400> 1650
ctgcaacaag ttaagctgaa gaccgaagca agagctggtt caggtggcag ccacagcagc       60

ctcagggacc tcagcaacta tggcctcctg cccagactct gataatagct gggtgcttgc      120

tggctccgag agcctgccag tggagacact gggcccggca tccaggatgg acccagaatc      180

tgagagagcc ctgcaggccc ctcacagccc ctccaagaca gatgggaaag aattagctgg      240

gaccatggat ggagaaggga cgctcttcca gactgaaagc cctcagtctg gcagcattct      300

aacagaggag actgaggtca agggcaccct ggaaggtgat gtttgtggtg tggagcctcc      360

tggcccagga gacacagtag tccagggaga cctgcaggag accaccgtgg tgacaggcct      420

gggaccagac acacaggacc tggaaggcca gagccctcca cagagcctgc cttcaacccc      480

caaagcagct tggatcaggg aggagggccg ctgctccagc agtgacgatg acaccgacgt      540

ggacatggag ggtctgcgga gacggcgggg ccgggaggcc ggcccacctc agcccatggt      600

gcccctggct gtggagaacc aggctggggg tggcctctca gagtctgaga ctgggcccat      660

ggaggaagtg gagcggcagg tcctcccaga ccccgaggtg ctggaagctg tgggggacag      720

gcaggatggg ctaagggaac agctgcaggc cccagtgcct cctgacagtg tccccagcct      780

gcaaaacatg ggtcttctgc tggacaagct ggccaaggag aaccaggaca tccggctgct      840

gcaggcccag ctgcaggtgg gcacaggcag gaggggctgg gctagggtaa cccacctagg      900

ccaggcgtct gtcctagcat cctcccccaa aaggaatgtt tcctatttac ccacacatcc      960

tgaccctccc ctctcccact atagtcaggg cgtcttccca gttcttggtt cacatccctt     1020

gtgctaaggt ttgggccagg gctggcatac ctgttccaca tggtacatga aacatacatg     1080

gtatcacctg tgattgattg gtgtggtctg cctggagcac tgtgtggaaa aggatttaaa     1140

gaacatgcca ggtgccatga tcagttaaca ctgtt                                1175


<210> 1651
<211> 3212
<212> DNA
<213> Homo sapiens

<400> 1651
aagttaagct gaagaccgaa gcaagagctg gttcaggtgg cagccacagc agcctcaggg       60

acctcagcaa ctatggcctc ctgcccagac tctgataata gctgggtgct tgctggctcc      120

gagagcctgc cagtggagac actgggcccg gcatccagga tggacccaga atctgagaga      180

gccctgcagg cccctcacag cccctccaag acagatggga aagaattagc tgggaccatg      240

gatggagaag ggacgctctt ccagactgaa agccctcagt ctggcagcat tctaacagag      300

gagactgagg tcaagggcac cctggaaggt gatgtttgtg gtgtggagcc tcctggccca      360

ggagacacag tagtccaggg agacctgcag gagaccaccg tggtgacagg cctgggacca      420

gacacacagg acctggaagg ccagagccct ccacagagcc tgccttcaac ccccaaagca      480

gcttggatca gggaggaggg ccgctgctcc agcagtgacg atgacaccga cgtggacatg      540

gagggtctgc ggagacggcg gggccgggag gccggcccac ctcagcccat ggtgcccctg      600

gctgtggaga accaggctgg gggtgagggt gcaggcgggg agctgggcat ctccctcaac      660

atgtgcctcc ttggggccct ggttctgctt ggcctggggg tcctcctctt ctcaggtggc      720

ctctcagagt ctgagactgg gcccatggag gaagtggagc ggcaggtcct cccagacccc      780

gaggtgctgg aagctgtggg ggacaggcag gatgggctaa gggaacagct gcaggcccca      840

gtgcctcctg acagtgtccc cagcctgcaa aacatgggtc ttctgctgga caagctggcc      900

aaggagaacc aggacatccg gctgctgcag gcccagctgc aggcccaaaa ggaagagctt      960

cagagcctga tgcaccagcc caaagggcta gaggaggaga atgcccagct ccggggggct     1020

ctgcagcagg gcgaagcctt ccagcgggct ctggagtcag agctgcagca gctgcgggcc     1080

cggctccagg ggctggaggc cgactgtgtc cggggcccag atggggtgtg cctcagtggg     1140

ggtagaggcc cacagggtga caaggccatc agggagcaag gccccaggga gcaggagcca     1200

gaactcagct tcctgaagca gaaggaacag ctggaggctg aggcacaggc attaaggcaa     1260

gagttagaga ggcagcgacg gctgctgggg tctgtacagc aggatctgga gaggagcttg     1320

caggatgcca gccgcgggga cccagctcat gctggcttgg ctgagctggg ccacagattg     1380

gcccagaaac tgcagggcct ggagaactgg ggccaggacc ctggggtctc tgccaatgcc     1440

tcaaaggcct ggcaccagaa gtcccacttc cagaattcta gggagtggag tggaaaggaa     1500

aagtggtggg atgggcagag agaccggaag gctgagcact ggaaacataa gaaggaagaa     1560

tctggccggg aaaggaagaa gaactgggga ggtcaggagg acagggagcc agcaggaagg     1620

tggaaggagg gcaggccaag ggtggaggag tcggggagca agaaggaggg caagcgacag     1680

ggcccgaagg aacccccaag gaaaagtggt agcttccact cctctggaga aaagcagaag     1740

caacctcggt ggagggaagg gactaaggac agccatgacc ccctgccatc ctgggcagag     1800

ctgttgaggc ccaagtaccg ggcaccccag ggctgctcag gtgtggacga gtgtgcccgg     1860

caggagggcc tgactttctt tggcacagag ctagccccag tgcggcaaca ggagctggcc     1920

tctctgctaa gaacatactt ggcacggctg ccctgggctg ggcagctgac caaggagcta     1980

cccctctcac ctgctttctt tggtgaggat ggcatcttcc gtcatgaccg cctccgcttc     2040

cgggattttg tggatgccct ggaggacagc ttggaggagg tggctgtgca acagacaggt     2100

gatgatgatg aagtagatga ctttgaggac ttcatcttca gccacttctt tggagacaaa     2160

gcactgaaga agaggtcagg gaagaaggac aagcactcac agagcccaag agctgcgggg     2220

cccagggagg ggcacagcca tagccaccac caccaccacc ggggctgaca ccctgcccca     2280

cagggaatgg ccttggcctg gcccagccca agatcccagc gttatctaac tcctggaggg     2340

tggactctgt cctggcttgt ttggtgtcct cagatatctt tcacacagta gagcaaaatc     2400

accagccctg cactgatgtc actttatgta gaaaaaggcc ttagctggac ctgcgttgcc     2460

gtctatgcaa atgcatgcaa atactccagg ccctgggatg tgggcttgtg ttttgtcact     2520

gtgaaggggg agatgggaga ggagcctgtt ttggggtggg gtctggggaa ggcaatctga     2580

ttctgaagct aaagagcttt catcctcttg agtgtatgtc cccatagtgg gccccttgac     2640

ccacatgctg accggtgcct tgggatttga ctagagttgc tggctcgagg cccagcacga     2700

ggacttaccc tggggttttg ttaggtttgg aagcagctgt ccctaggggg tgaagtcccc     2760

cccctttttt tttttacccc tgcttctccc acggcttcac ctccctatgt gaactgtaga     2820

ctcagatccc aataaagtgc tgttgcagct atgatgctag gtggtttcta agcacagggg     2880

acaccccaca ccccctgcct gaatggatgg gtccatccca ggcactggta cttgccccct     2940

tgttctgtat ccccctttgc ccttgccttg cccttccaac aaaccctagg cccttgagaa     3000

gctgatactt ctccttttgc tcacagctgc cttggcccca cccctgggag atgtagcaaa     3060

ttgagtgtgg gttttggagt ctgagcctca ggctcaaatc caggccaagt gatcttgggc     3120

aagttaatct ctgggaactt tgggtttctt atcctcaaaa aaggcgatgg aagggctggg     3180

gaagtgatta aataaaagca acgcaagaaa aa                                   3212


<210> 1652
<211> 3144
<212> DNA
<213> Homo sapiens

<400> 1652
aaagggaagc ctgcaacaag ttaagctgaa gaccgaagca agagctggtt cagcctgcca       60

gtggagacac tgggcccggc atccaggatg gacccagaat ctgagagagc cctgcaggcc      120

cctcacagcc cctccaagac agatgggaaa gaattagctg ggaccatgga tggagaaggg      180

acgctcttcc agactgaaag ccctcagtct ggcagcattc taacagagga gactgaggtc      240

aagggcaccc tggaaggtga tgtttgtggt gtggagcctc ctggcccagg agacacagta      300

gtccagggag acctgcagga gaccaccgtg gtgacaggcc tgggaccaga cacacaggac      360

ctggaaggcc agagccctcc acagagcctg ccttcaaccc ccaaagcagc ttggatcagg      420

gaggagggcc gctgctccag cagtgacgat gacaccgacg tggacatgga gggtctgcgg      480

agacggcggg gccgggaggc cggcccacct cagcccatgg tgcccctggc tgtggagaac      540

caggctgggg gtgagggtgc aggcggggag ctgggcatct ccctcaacat gtgcctcctt      600

ggggccctgg ttctgcttgg cctgggggtc ctcctcttct caggtggcct ctcagagtct      660

gagactgggc ccatggagga agtggagcgg caggtcctcc cagaccccga ggtgctggaa      720

gctgtggggg acaggcagga tgggctaagg gaacagctgc aggccccagt gcctcctgac      780

agtgtcccca gcctgcaaaa catgggtctt ctgctggaca agctggccaa ggagaaccag      840

gacatccggc tgctgcaggc ccagctgcag gcccaaaagg aagagcttca gagcctgatg      900

caccagccca aagggctaga ggaggagaat gcccagctcc ggggggctct gcagcagggc      960

gaagccttcc agcgggctct ggagtcagag ctgcagcagc tgcgggcccg gctccagggg     1020

ctggaggccg actgtgtccg gggcccagat ggggtgtgcc tcagtggggg tagaggccca     1080

cagggtgaca aggccatcag ggagcaaggc cccagggagc aggagccaga actcagcttc     1140

ctgaagcaga aggaacagct ggaggctgag gcacaggcat taaggcaaga gttagagagg     1200

cagcgacggc tgctggggtc tgtacagcag gatctggaga ggagcttgca ggatgccagc     1260

cgcggggacc cagctcatgc tggcttggct gagctgggcc acagattggc ccagaaactg     1320

cagggcctgg agaactgggg ccaggaccct ggggtctctg ccaatgcctc aaaggcctgg     1380

caccagaagt cccacttcca gaattctagg gagtggagtg gaaaggaaaa gtggtgggat     1440

gggcagagag accggaaggc tgagcactgg aaacataaga aggaagaatc tggccgggaa     1500

aggaagaaga actggggagg tcaggaggac agggagccag caggaaggtg gaaggagggc     1560

aggccaaggg tggaggagtc ggggagcaag aaggagggca agcgacaggg cccgaaggaa     1620

cccccaagga aaagtggtag cttccactcc tctggagaaa agcagaagca acctcggtgg     1680

agggaaggga ctaaggacag ccatgacccc ctgccatcct gggcagagct gttgaggccc     1740

aagtaccggg caccccaggg ctgctcaggt gtggacgagt gtgcccggca ggagggcctg     1800

actttctttg gcacagagct agccccagtg cggcaacagg agctggcctc tctgctaaga     1860

acatacttgg cacggctgcc ctgggctggg cagctgacca aggagctacc cctctcacct     1920

gctttctttg gtgaggatgg catcttccgt catgaccgcc tccgcttccg ggattttgtg     1980

gatgccctgg aggacagctt ggaggaggtg gctgtgcaac agacaggtga tgatgatgaa     2040

gtagatgact ttgaggactt catcttcagc cacttctttg gagacaaagc actgaagaag     2100

aggtcaggga agaaggacaa gcactcacag agcccaagag ctgcggggcc cagggagggg     2160

cacagccata gccaccacca ccaccaccgg ggctgacacc ctgccccaca gggaatggcc     2220

ttggcctggc ccagcccaag atcccagcgt tatctaactc ctggagggtg gactctgtcc     2280

tggcttgttt ggtgtcctca gatatctttc acacagtaga gcaaaatcac cagccctgca     2340

ctgatgtcac tttatgtaga aaaaggcctt agctggacct gcgttgccgt ctatgcaaat     2400

gcatgcaaat actccaggcc ctgggatgtg ggcttgtgtt ttgtcactgt gaagggggag     2460

atgggagagg agcctgtttt ggggtggggt ctggggaagg caatctgatt ctgaagctaa     2520

agagctttca tcctcttgag tgtatgtccc catagtgggc cccttgaccc acatgctgac     2580

cggtgccttg ggatttgact agagttgctg gctcgaggcc cagcacgagg acttaccctg     2640

gggttttgtt aggtttggaa gcagctgtcc ctagggggtg aagtcccccc cctttttttt     2700

tttacccctg cttctcccac ggcttcacct ccctatgtga actgtagact cagatcccaa     2760

taaagtgctg ttgcagctat gatgctaggt ggtttctaag cacaggggac accccacacc     2820

ccctgcctga atggatgggt ccatcccagg cactggtact tgcccccttg ttctgtatcc     2880

ccctttgccc ttgccttgcc cttccaacaa accctaggcc cttgagaagc tgatacttct     2940

ccttttgctc acagctgcct tggccccacc cctgggagat gtagcaaatt gagtgtgggt     3000

tttggagtct gagcctcagg ctcaaatcca ggccaagtga tcttgggcaa gttaatctct     3060

gggaactttg ggtttcttat cctcaaaaaa ggcgatggaa gggctgggga agtgattaaa     3120

taaaagcaac gcaagaaaaa tgcc                                            3144


<210> 1653
<211> 7118
<212> DNA
<213> Homo sapiens

<400> 1653
gcctatcatt tgaagacgtt ccttgaggag gtttgaaaaa aaacagctga cccttggcta       60

acattacatg atttggagaa ataattggaa gtctaccaca gggagactaa atgtaaaact      120

ccaatcagat aaattacaac acggatgtgg cccagattat tcatcagcat ggctacctgc      180

taatgaatca ttgtggcagg ccacaactgt tccatctaac catcgaaata accatatcag      240

gagacacagt atagcttctg acagtggaga cactggcatt ggaacttcct gttctgatag      300

cgtggaagat cattcaactt caagtggcac attatctttt aagcctagtc aatcattgat      360

tactcttcct actgcccatg tgatgccgtc taattccagc gcttcaattt ccaaacttag      420

ggaatcattg acaccagatg gctcaaaatg gagtacaagc ctcatgcaaa cattgggaaa      480

ccacagtagg ggggagcagg actcttccct agacatgaag gacttccggc cacttcggaa      540

atggtcatct ttatccaaac tcactgcccc ggataactgt ggccagggtg gcactgtatg      600

cagagaagag tcaaggaatg gtttggagaa gatagggaag gctaaggctt taacatcaca      660

actgaggaca attgggccta gctgtttaca tgatagtatg gagatgctta ggttagagga      720

caaggaaata aataaaaaac ggtcatcaac tctggactgc aagtataaat ttgagagctg      780

tagcaaggag gactttagag cctcttcctc tactcttagg agacagcctg tagacatgac      840

atatagtgcc ttacctgaaa gcaagcccat tatgacaagc tcagaggctt ttgaacctcc      900

aaaatattta atgcttggtc aacaggcagt aggtggagtt cccattcagc cttccgtaag      960

gactcagatg tggcttacag agcagctgcg gacaaatcct ttggaaggta gaaatacaga     1020

ggattcttac agtttagctc cttggcaaca gcagcaaatt gaagactttc gacaaggaag     1080

tgaaacacca atgcaggttt tgactggatc atctcgtcaa agttattcac ctggctatca     1140

ggatttcagt aagtgggaat caatgttgaa aataaaagaa ggacttctaa ggcagaaaga     1200

aattgtaatc gatcggcaga agcaacaaat tacccacctg catgagagga taagggataa     1260

tgaattacgg gctcaacatg ccatgttagg acattatgta aattgtgagg attcttatgt     1320

ggctagtttg cagccacaat atgagaacac ttcactccag acaccatttt cagaggaatc     1380

agtttcccat tcccaacaag gggaatttga gcaaaagctt gcatctactg agaaagaagt     1440

tttacagctt aatgagtttc tcaaacaaag actaagccta tttagtgaag agaagaagaa     1500

actagaggaa aaacttaaaa ctagagatcg atacatcagt agtctgaaaa agaaatgcca     1560

gaaggaatct gaacaaaaca aagaaaagca gagaagaatt gagaccttgg aaaagtatct     1620

ggctgatctt ccaactctag atgatgtaca gagtcagagt ctacagctgc agattctgga     1680

agaaaaaaat aagaatttac aagaggcttt gatagataca gaaaaaaaac ttgaagagat     1740

caaaaagcag tgtcaagata aagagacaca gttaatatgc cagaaaaaga aagaaaagga     1800

gttagtaact accgttcaga gtttgcaaca aaaagtagaa agatgccttg aagatggaat     1860

ccgccttccc atgttagatg caaaacagct tcagaatgaa aatgataatc tcagacaaca     1920

aaatgagact gctagtaaga taatagacag ccaacaagat gagattgaca gaatgatttt     1980

agaaattcag tctatgcaag gaaagctttc taaagagaaa ctgaccactc aaaagatgat     2040

ggaagagctg gaaaagaaag aaagaaatgt acagagatta acaaaagcat tgcttgaaaa     2100

ccaaagacaa acagatgaga catgctcttt attggatcag ggccaggaac ctgaccaatc     2160

taggcagcag acagttcttt ccaaacggcc actatttgat ttgactgtga ttgatcagct     2220

gttcaaggaa atgtcctgtt gtttgtttga cttgaaagca ttgtgtagta ttcttaatca     2280

gcgtgctcag ggcaaggagc ctaatctttc attattactg ggaataagat caatgaactg     2340

ttcagctgaa gagactgaga atgaccacag cacagaaaca ctcactaaaa agctgtcaga     2400

tgtgtgccag ttacgaagag acattgatga attaaggact acaatatcag accgctatgc     2460

tcaggacatg ggagacaact gcattactca gtgatcaagt gttagtccca cagcaataat     2520

gacctgttgt ttaaatgctg ctgtgttatg gagccataat ggaaggttgc aagtgacatg     2580

acttgcactt agggattttt tttctgtgga tttgttttgt tgaaggggag aagggaagtg     2640

aagagatttt gaaggggctt atctaatcag gcaaaaagaa aaaaaatcaa attacctttg     2700

gaaaatatga taaaatctac aaggaaaaaa atgtctatat tctcaaacta ctgattgtag     2760

gaccaagctg tgaagagtac ccttcacatg aaggagtagg attcctttta atcctatagc     2820

tttgtgtgtt tgtgtgtgca tgtatgtgtg ttgttgtgtg tgtgtgcacg tgctttattc     2880

acaaatttat aagggtttct agggtcagag cagagcttct gagaaaggca cacgctgttt     2940

attcttatat ttctttcata tagaagcttg tgttgtactt tgggattttc agtggctggc     3000

tgaacaagag ttcaaacagc aggcaagtgt tgtcatggta gtacaggagg caaaaccatt     3060

tatattttga acacttactg cactgatagg atgtttgtgg ttgagctgat tttagtactg     3120

tagataggtc agctgttttt ccagagtgat tgtggatttc ccaagaggtg tgaaattttg     3180

acgtgatgct ctttttcctt agcattgtaa tgtatgtgtt acaagaaagg ttaacataac     3240

ttgaactaat tttaacatgt tccttactat ttacaatttt ttatttatat gttttatata     3300

tatacatata taaatgtaaa caaagccata tataattaat aaaggcattg gatcattatt     3360

ataaaaggaa gattaacaaa gttaccctgg aacaatagct tacttatcca aatctcaaca     3420

tttacatttt aacagttttg tatgtttcaa agttgaaact actgtaagag aaagccaata     3480

ctatttatat ctgaatcaac agtagcataa acatttttta attgagattg tattttaatc     3540

ccttttgtta aagtacatta acaacagttt ttcacaggat atgaacttgg cgaaattagt     3600

tcttaatctg aattacaggg tattactatg aaatgcagtt gattttgcag tagacgtaca     3660

gtcatttaaa cttccaaatg agtgttgtcc atgtttctgt tggtattttg gaaggattat     3720

acattttatt gccttcagca ttgattatgt tcttttgaat atacttagtt ttggcgaaag     3780

ccttgtcctt tgtaagttgg tttgatcttg tgatgcaacc aagtctcatt taggtcaaga     3840

ctaaataaga gatggagggg tagagggtgt gactcaagca ggataatatt gatttgataa     3900

agagcatatc acatgcctgt tttcttgcca gataaagggc atagcacatg cctgttttct     3960

tatatactag aataaaggct ctcctaggaa agatttttct taaatattta aaagtgaaaa     4020

tgtgagacaa ggccttcaag gagactaccc aggaagatac acagtttaaa atgttggcta     4080

tacagctctc aatagattat tttatagtta tagttgaata atcagttata atacactgta     4140

aagaaatcag attttccttc tgtttggtgt ctgagtcctt cctgctcttc ttacttctga     4200

gaatctgggc actaagaaat cagtaagtac attgtagtgc tcctgcatcc cagagtcctt     4260

aacctaagga gggtcttagt cactggtaag aacttggctt tctaattata ttcacttggt     4320

ttttaacatt agtagcttga cgataatcag ggtatagtaa atttccacca aaaatgtgat     4380

gcgaagaatt ctgccttggt cctttatggt aaaacagata ataacgtcta aaatagatca     4440

gccacaagtg cagcaaatat ttttacactc tctttgaata gaatcccaac caccctcccc     4500

catgatttta gaaataaagg cttcctaaaa taatagaaca aattggcaaa caatcactaa     4560

ttggaccagt aggttcttac ttaaatatct ctcctagatt tttagtgtat gttttgggat     4620

tttatgggtt tatttatttt ttttttttta agcagacgtt acagtttgtt ttaatctact     4680

atagatacgt ttttgttttt tggcttagtt ggggataaaa taatttattt gtaagttagc     4740

tttctaaaac ttagagaaag taatttaatt cacgtatctt aaaaataaaa ttccaaagtt     4800

aaaaaatttc tgacttagta ggaagttaac aaaactactg ctgatgcatt tcagtttcca     4860

aaatctgtac cctcccccca taaaaaaggg agttaagatg tgctagttta agtagttagc     4920

tgaattatag attgatcctc ttaaaatctg gagtttgtaa aggggcctac ataaacagta     4980

gatagacttg gagggatttt gtgggggaat tgaaactaat agtattctat ctagtttgtc     5040

agtatttact ttttgatttt tatttttcag aaaattttcc tttcccagga caccctcttg     5100

tattagaata tcctcttctg tatcacatta aaaacagatt ttactgttag accaaataag     5160

atgggcaaat agcaacacta gagcatctca cccagtttga actaggatgt tcgtggaagt     5220

tatgacacca atatattcct gaaatgaaaa ttaacctaaa ttttaaagtg aatctatttg     5280

aaaatttact tagataatga aacctcgttt taattgtgct ttttgtgaat ccaacacttg     5340

tttgcttaga aagtatctta tccagtatta atattttgtt cttttgggtt ttaaagttga     5400

gcttattcag cctcaatcac attacagcaa gcataaagta acagttgact caatgaaaga     5460

cccaaattgc ctgtacagat aaaattcact gaatcaaagg cacaatagct atcttttcac     5520

ttgagctcag aaaagtaaaa tggcttaatt tgaactatta attttcagtg gcctctaatt     5580

aaacaaaaac aaaaaaccac aaatactggc taggtaagat attcctgagg tcattttaaa     5640

agaagtgtgg cacctaggat tcaatattta atgctaacag tattatattt tagtgaaatt     5700

tattttggtg gtgacagttt attaaaccta attagacttc tttcaatagc ttgttgtaga     5760

gacaatctca agggctggaa agtgttgcta aaatgaatgt catacatttc tgatatacta     5820

aggagcttat aaagtaattc tttcatagtg caagaattat taatttctta gaggatgttt     5880

ttaaaggagc tacttaattg ggaaaatgtt ctttaaatat cagtaatagt tcattaagta     5940

acatagtagc taagaacatg gactatattt tcacagcata gttcagctta ggcacacctt     6000

tagtttggat tattggcatt ctcttacgta ggaattatat cattgtagat atgtaattat     6060

ggtaataagc aattttcata accatgctca ctcagactat atcatttgaa actgccatgt     6120

ttccattttt gacaattcat gttcacaaaa caacaggaac aatttcctat ttggtataaa     6180

gagcaaaatt tccaactttg ccccaaaatg ccatgggtgg catattgcca tatgattata     6240

tcatatattt aatcatgtat gggaaagatt ttggattttt tttcttattt aaaaaagtgc     6300

taaatataag aatatagttt taaatcagca agtctaataa cactattgca gctgtacaca     6360

gagagaacct tttgtgcctt tttgcctgca gtaagcattt atttctattt tacatgagtt     6420

ctaagaatgt tgatgattat tgcaccttgt tcttctgtat ataaacttga ttaaggaatt     6480

ttttttttta aagcaaggag ccgttttttg ttactaggtg gataccttag taaacatgag     6540

gggaattatc agatagatgt ctttggagcc cagccttccc tgtgtagtga gctggaaact     6600

cctttagatt gtattcattg gtgtgtatgt atatgtacat atatgtataa atagttaaat     6660

acataaacat aaaacttaac atcgcattgt tgtgatgaca agaagtagta aggtgctagg     6720

tggttacatt aaaaagcaca gcacagtgta taatcagtca ctatgactgg tggttttgta     6780

agctgggttc agtttttgaa ccacccagaa tacctcatgt gtaaatacag tgttcatgac     6840

ttaattgaaa tacagttatt gtttaaaaaa aaaaaaaaag aatgtgaagc cactggttgg     6900

cttatgcctt ctgatctatc attcttgcct ctttttttgt aaaggggttt tcttcttgtt     6960

gttctgtttt ttaatagggt ttacagctag aattttgaat gccaaagttc tatttattaa     7020

attaagaaaa aagttttcaa tgttaatggc tagtattttt ccactggact attgtttgtt     7080

gatgttggaa tttgtattta cagagaaata aatttttt                             7118


<210> 1654
<211> 7673
<212> DNA
<213> Homo sapiens

<400> 1654
gggagggcgt gagggattac ccaagggagg ggcgagtatc gcaaaatagg ccaagtcgct       60

gccctctact caactcgcag ggcgggagga tggagacaga gggatgcggc gggagggcgg      120

gacagcccag tcgccgccaa ggaggcgaag cggggtcggg gtagctcacc cgccccccgc      180

agtccccgcc ccccgcagtc cccgccccgc gcggcgccgc gcacgcctga agtcattgcc      240

cgaggccccg ccccctcgcg gccccagccc cggctctggc tctgccggcg gagggggcgg      300

agagaacccg cagctgcaac ttcgcctgga gcctttgagc ctgggctcag ccggggatct      360

agcagccgtc accgccgagt cgccgcttcc ccggcgcggg cctcagccca gccggcttgg      420

ccatggcagg cgccggcagt gcggcgaatc tggcccctgc gctccccgcc cgtagctgag      480

cagccgttaa ccagccatcc cgcctttcct cctgcccgtg tcgccgaggc ccacgctccg      540

cgcaagtttc cgccgccgaa gaagcaggag gacggacgtg aggagtcggg cgtccctggc      600

ccacccggcc ctctcgcccg cgatgtgggg gcgcttcctg gctccggagg ccagcggccg      660

ggatagcccc ggcggagccc gcagcttccc tgccggccca gattattcat cagcatggct      720

acctgctaat gaatcattgt ggcaggccac aactgttcca tctaaccatc gaaataacca      780

tatcaggaga cacagtatag cttctgacag tggagacact ggcattggaa cttcctgttc      840

tgatagcgtg gaagatcatt caacttcaag tggcacatta tcttttaagc ctagtcaatc      900

attgattact cttcctactg cccatgtgat gccgtctaat tccagcgctt caatttccaa      960

acttagggaa tcattgacac cagatggctc aaaatggagt acaagcctca tgcaaacatt     1020

gggaaaccac agtagggggg agcaggactc ttccctagac atgaaggact tccggccact     1080

tcggaaatgg tcatctttat ccaaactcac tgccccggat aactgtggcc agggtggcac     1140

tgtatgcaga gaagagtcaa ggaatggttt ggagaagata gggaaggcta aggctttaac     1200

atcacaactg aggacaattg ggcctagctg tttacatgat agtatggaga tgcttaggtt     1260

agaggacaag gaaataaata aaaaacggtc atcaactctg gactgcaagt ataaatttga     1320

gagctgtagc aaggaggact ttagagcctc ttcctctact cttaggagac agcctgtaga     1380

catgacatat agtgccttac ctgaaagcaa gcccattatg acaagctcag aggcttttga     1440

acctccaaaa tatttaatgc ttggtcaaca ggcagtaggt ggagttccca ttcagccttc     1500

cgtaaggact cagatgtggc ttacagagca gctgcggaca aatcctttgg aaggtagaaa     1560

tacagaggat tcttacagtt tagctccttg gcaacagcag caaattgaag actttcgaca     1620

aggaagtgaa acaccaatgc aggttttgac tggatcatct cgtcaaagtt attcacctgg     1680

ctatcaggat ttcagtaagt gggaatcaat gttgaaaata aaagaaggac ttctaaggca     1740

gaaagaaatt gtaatcgatc ggcagaagca acaaattacc cacctgcatg agaggataag     1800

ggataatgaa ttacgggctc aacatgccat gttaggacat tatgtaaatt gtgaggattc     1860

ttatgtggct agtttgcagc cacaatatga gaacacttca ctccagacac cattttcaga     1920

ggaatcagtt tcccattccc aacaagggga atttgagcaa aagcttgcat ctactgagaa     1980

agaagtttta cagcttaatg agtttctcaa acaaagacta agcctattta gtgaagagaa     2040

gaagaaacta gaggaaaaac ttaaaactag agatcgatac atcagtagtc tgaaaaagaa     2100

atgccagaag gaatctgaac aaaacaaaga aaagcagaga agaattgaga ccttggaaaa     2160

gtatctggct gatcttccaa ctctagatga tgtacagagt cagagtctac agctgcagat     2220

tctggaagaa aaaaataaga atttacaaga ggctttgata gatacagaaa aaaaacttga     2280

agagatcaaa aagcagtgtc aagataaaga gacacagtta atatgccaga aaaagaaaga     2340

aaaggagtta gtaactaccg ttcagagttt gcaacaaaaa gtagaaagat gccttgaaga     2400

tggaatccgc cttcccatgt tagatgcaaa acagcttcag aatgaaaatg ataatctcag     2460

acaacaaaat gagactgcta gtaagataat agacagccaa caagatgaga ttgacagaat     2520

gattttagaa attcagtcta tgcaaggaaa gctttctaaa gagaaactga ccactcaaaa     2580

gatgatggaa gagctggaaa agaaagaaag aaatgtacag agattaacaa aagcattgct     2640

tgaaaaccaa agacaaacag atgagacatg ctctttattg gatcagggcc aggaacctga     2700

ccaatctagg cagcagacag ttctttccaa acggccacta tttgatttga ctgtgattga     2760

tcagctgttc aaggaaatgt cctgttgttt gtttgacttg aaagcattgt gtagtattct     2820

taatcagcgt gctcagggca aggagcctaa tctttcatta ttactgggaa taagatcaat     2880

gaactgttca gctgaagaga ctgagaatga ccacagcaca gaaacactca ctaaaaagct     2940

gtcagatgtg tgccagttac gaagagacat tgatgaatta aggactacaa tatcagaccg     3000

ctatgctcag gacatgggag acaactgcat tactcagtga tcaagtgtta gtcccacagc     3060

aataatgacc tgttgtttaa atgctgctgt gttatggagc cataatggaa ggttgcaagt     3120

gacatgactt gcacttaggg attttttttc tgtggatttg ttttgttgaa ggggagaagg     3180

gaagtgaaga gattttgaag gggcttatct aatcaggcaa aaagaaaaaa aatcaaatta     3240

cctttggaaa atatgataaa atctacaagg aaaaaaatgt ctatattctc aaactactga     3300

ttgtaggacc aagctgtgaa gagtaccctt cacatgaagg agtaggattc cttttaatcc     3360

tatagctttg tgtgtttgtg tgtgcatgta tgtgtgttgt tgtgtgtgtg tgcacgtgct     3420

ttattcacaa atttataagg gtttctaggg tcagagcaga gcttctgaga aaggcacacg     3480

ctgtttattc ttatatttct ttcatataga agcttgtgtt gtactttggg attttcagtg     3540

gctggctgaa caagagttca aacagcaggc aagtgttgtc atggtagtac aggaggcaaa     3600

accatttata ttttgaacac ttactgcact gataggatgt ttgtggttga gctgatttta     3660

gtactgtaga taggtcagct gtttttccag agtgattgtg gatttcccaa gaggtgtgaa     3720

attttgacgt gatgctcttt ttccttagca ttgtaatgta tgtgttacaa gaaaggttaa     3780

cataacttga actaatttta acatgttcct tactatttac aattttttat ttatatgttt     3840

tatatatata catatataaa tgtaaacaaa gccatatata attaataaag gcattggatc     3900

attattataa aaggaagatt aacaaagtta ccctggaaca atagcttact tatccaaatc     3960

tcaacattta cattttaaca gttttgtatg tttcaaagtt gaaactactg taagagaaag     4020

ccaatactat ttatatctga atcaacagta gcataaacat tttttaattg agattgtatt     4080

ttaatccctt ttgttaaagt acattaacaa cagtttttca caggatatga acttggcgaa     4140

attagttctt aatctgaatt acagggtatt actatgaaat gcagttgatt ttgcagtaga     4200

cgtacagtca tttaaacttc caaatgagtg ttgtccatgt ttctgttggt attttggaag     4260

gattatacat tttattgcct tcagcattga ttatgttctt ttgaatatac ttagttttgg     4320

cgaaagcctt gtcctttgta agttggtttg atcttgtgat gcaaccaagt ctcatttagg     4380

tcaagactaa ataagagatg gaggggtaga gggtgtgact caagcaggat aatattgatt     4440

tgataaagag catatcacat gcctgttttc ttgccagata aagggcatag cacatgcctg     4500

ttttcttata tactagaata aaggctctcc taggaaagat ttttcttaaa tatttaaaag     4560

tgaaaatgtg agacaaggcc ttcaaggaga ctacccagga agatacacag tttaaaatgt     4620

tggctataca gctctcaata gattatttta tagttatagt tgaataatca gttataatac     4680

actgtaaaga aatcagattt tccttctgtt tggtgtctga gtccttcctg ctcttcttac     4740

ttctgagaat ctgggcacta agaaatcagt aagtacattg tagtgctcct gcatcccaga     4800

gtccttaacc taaggagggt cttagtcact ggtaagaact tggctttcta attatattca     4860

cttggttttt aacattagta gcttgacgat aatcagggta tagtaaattt ccaccaaaaa     4920

tgtgatgcga agaattctgc cttggtcctt tatggtaaaa cagataataa cgtctaaaat     4980

agatcagcca caagtgcagc aaatattttt acactctctt tgaatagaat cccaaccacc     5040

ctcccccatg attttagaaa taaaggcttc ctaaaataat agaacaaatt ggcaaacaat     5100

cactaattgg accagtaggt tcttacttaa atatctctcc tagattttta gtgtatgttt     5160

tgggatttta tgggtttatt tatttttttt tttttaagca gacgttacag tttgttttaa     5220

tctactatag atacgttttt gttttttggc ttagttgggg ataaaataat ttatttgtaa     5280

gttagctttc taaaacttag agaaagtaat ttaattcacg tatcttaaaa ataaaattcc     5340

aaagttaaaa aatttctgac ttagtaggaa gttaacaaaa ctactgctga tgcatttcag     5400

tttccaaaat ctgtaccctc cccccataaa aaagggagtt aagatgtgct agtttaagta     5460

gttagctgaa ttatagattg atcctcttaa aatctggagt ttgtaaaggg gcctacataa     5520

acagtagata gacttggagg gattttgtgg gggaattgaa actaatagta ttctatctag     5580

tttgtcagta tttacttttt gatttttatt tttcagaaaa ttttcctttc ccaggacacc     5640

ctcttgtatt agaatatcct cttctgtatc acattaaaaa cagattttac tgttagacca     5700

aataagatgg gcaaatagca acactagagc atctcaccca gtttgaacta ggatgttcgt     5760

ggaagttatg acaccaatat attcctgaaa tgaaaattaa cctaaatttt aaagtgaatc     5820

tatttgaaaa tttacttaga taatgaaacc tcgttttaat tgtgcttttt gtgaatccaa     5880

cacttgtttg cttagaaagt atcttatcca gtattaatat tttgttcttt tgggttttaa     5940

agttgagctt attcagcctc aatcacatta cagcaagcat aaagtaacag ttgactcaat     6000

gaaagaccca aattgcctgt acagataaaa ttcactgaat caaaggcaca atagctatct     6060

tttcacttga gctcagaaaa gtaaaatggc ttaatttgaa ctattaattt tcagtggcct     6120

ctaattaaac aaaaacaaaa aaccacaaat actggctagg taagatattc ctgaggtcat     6180

tttaaaagaa gtgtggcacc taggattcaa tatttaatgc taacagtatt atattttagt     6240

gaaatttatt ttggtggtga cagtttatta aacctaatta gacttctttc aatagcttgt     6300

tgtagagaca atctcaaggg ctggaaagtg ttgctaaaat gaatgtcata catttctgat     6360

atactaagga gcttataaag taattctttc atagtgcaag aattattaat ttcttagagg     6420

atgtttttaa aggagctact taattgggaa aatgttcttt aaatatcagt aatagttcat     6480

taagtaacat agtagctaag aacatggact atattttcac agcatagttc agcttaggca     6540

cacctttagt ttggattatt ggcattctct tacgtaggaa ttatatcatt gtagatatgt     6600

aattatggta ataagcaatt ttcataacca tgctcactca gactatatca tttgaaactg     6660

ccatgtttcc atttttgaca attcatgttc acaaaacaac aggaacaatt tcctatttgg     6720

tataaagagc aaaatttcca actttgcccc aaaatgccat gggtggcata ttgccatatg     6780

attatatcat atatttaatc atgtatggga aagattttgg attttttttc ttatttaaaa     6840

aagtgctaaa tataagaata tagttttaaa tcagcaagtc taataacact attgcagctg     6900

tacacagaga gaaccttttg tgcctttttg cctgcagtaa gcatttattt ctattttaca     6960

tgagttctaa gaatgttgat gattattgca ccttgttctt ctgtatataa acttgattaa     7020

ggaatttttt tttttaaagc aaggagccgt tttttgttac taggtggata ccttagtaaa     7080

catgagggga attatcagat agatgtcttt ggagcccagc cttccctgtg tagtgagctg     7140

gaaactcctt tagattgtat tcattggtgt gtatgtatat gtacatatat gtataaatag     7200

ttaaatacat aaacataaaa cttaacatcg cattgttgtg atgacaagaa gtagtaaggt     7260

gctaggtggt tacattaaaa agcacagcac agtgtataat cagtcactat gactggtggt     7320

tttgtaagct gggttcagtt tttgaaccac ccagaatacc tcatgtgtaa atacagtgtt     7380

catgacttaa ttgaaataca gttattgttt aaaaaaaaaa aaaaagaatg tgaagccact     7440

ggttggctta tgccttctga tctatcattc ttgcctcttt ttttgtaaag gggttttctt     7500

cttgttgttc tgttttttaa tagggtttac agctagaatt ttgaatgcca aagttctatt     7560

tattaaatta agaaaaaagt tttcaatgtt aatggctagt atttttccac tggactattg     7620

tttgttgatg ttggaatttg tatttacaga gaaataaatt ttttataaaa aga            7673


<210> 1655
<211> 2685
<212> DNA
<213> Homo sapiens

<400> 1655
ctggtggggt ctgtcggctt ctcttcagtg cgatatattt aaatggataa aaatatgtta       60

gttcccaaag aattgtatta tgtctattac gtcaagatac cgttgttgaa atattttcaa      120

aaaatacatt agtgatgtgg aaatgttatt tctttactaa tggaccaaat aaaatctggt      180

ataatgggca cctttaaaga aagcaccttc acacttgaag tgcgtaaatg atgtttgaag      240

ttgttcagat gatgacgtgg agatgtctgg tttctgtcaa tgttggcccc gcctacccca      300

cacgagcatc attttgggtg tcagggcccc acgcacccca cacgagcatc attttgttgc      360

ctgggctcat catggaagga aatgctaaat tccaaaaaga ggtgggtgca gataaagaca      420

aatcagtttc ccacctatct ctgcggaccg tacattctcc ctgagcccag gttaaatact      480

ccgttccaga gcgaggtttg taggtttgtt ggttttcttt tttttttttt tctttttttt      540

tttgaggcag agtctcgctc cattgccagg ctggagtgca gtggcatgat ctcggctcgc      600

tgcaaccccc acctcccagg ttcaagcgat tcccctgcct taacctccca agtagctggg      660

actacaggtg cacaccacca cgcccagctg attttttgta ttttagtaga gacggggttt      720

cactgtgttg gccaggatgg tcttgatctc ttgacttcgt gatctgccca cctcagcctc      780

ccaaagtgct ggggttacag gcgtgagcca ctgtgcccgg cccctaggtt cgttttagcc      840

gagaagtgtt ggggttacag gcgtgagcca ccgtgcccgg cccctaggtt cgttttagcc      900

cacagttgag aagtaactgg tagattaggc tcggcccttg tggaacgtta cttggaagtg      960

tgctggcctc tgttaatgtc cctgcgcgct gccggcctgg agaagtgtcg cctgcctcag     1020

gcgcccttgc tttgcctgtg accgaagcgc tccctgtggt tttagtgagt ttatggtcga     1080

ggagcacgag ctgcggaagg agaggatcca ggaggattac aacgacaagt actgggacca     1140

gcggtacacc atcgtccagc agcagatccc gtccttcctg cagaaaatgg cggacaagat     1200

cctcagcaca ggaaaatatc taaatgtggt cagagagtgt ggccatgacg tcacctgccc     1260

ggtggctaaa gagatcatct acacgttaaa agagcgggcg tatgtggagc agatcgagaa     1320

ggcgtttaac tacgccagca aggtgctgct ggacttcctg atggaggaga aggagctggt     1380

ggctcacctc aggtccatca agcgctactt cctcatggac cagggcgact tcttcgtgca     1440

cttcatggac ctcgcggagg aggagctccg gaagccggtg gaggacatca cgccccctcg     1500

cctggaagcg ctcctggagc tggcgctgcg catgagcacg gccaacactg accccttcaa     1560

ggacgacctc aagatcgacc tgatgcccca tgacctcatc actcagctct tgcgcgtcct     1620

ggccatcgag accaagcagg agaaggcgat ggcgcacgcc gaccccacgg agctggcgct     1680

gagcggcctg gaggccttct ctttcgacta catcgtcaag tggccccttt cgctcatcat     1740

caacaggaaa gccctcactc gctaccagat gctcttcagg cacatgttct actgcaagca     1800

cgtggagcgg cagctctgca gcgtctggat cagcaacaaa accgccaagc agcactcgct     1860

gcactccgcc cagtggtttg ctggggcttt cactctgcgg cagcgaatgc tcaacttcgt     1920

ccagaatatt caatactaca tgatgtttga agtgatggaa ccgacctggc acatcctgga     1980

gaaaaacctg aaatccgcct ccaacattga cgacgtcctt ggccaccaca caggcttcct     2040

ggacacctgc ctgaaggact gcatgctcac caaccccgag ctgctgaagg tcttctccaa     2100

gctcatgtct gtgtgcgtca tgttcaccaa ctgcatgcag aaatttacac agagcatgaa     2160

attagatggc gagctgggcg ggcagacgct ggagcacagc accgtcctgg ggctgcccgc     2220

aggggccgag gagcgggccc ggaaggagct cgccaggaag cacctggctg agcacgcaga     2280

cactgtgcag ctggtgtccg gcttcgaggc caccatcaac aagtttgaca agaacttctc     2340

agcccacctg ctggacctcc tggcccggct gagcatctat agcaccagtg actgtgagca     2400

cggcatggcc agcgtcatct ccaggcttga cttcaatggt ttctacacgg agcgcctgga     2460

gcgcctgtct gcagagagga gccagaaggc caccccccaa gtgcctgtcc tgcgggggcc     2520

cccggctcct gcacccaggg tcgcagtcac cgcacagtga gccctggctg tgacaggaag     2580

gaagggtgtg gggtcagcag ggactggtgc aaatgggtcc agaattttca aatcgaatgc     2640

tctgtgttct gtctttgcag tttaaatata aagcaggaat gattg                     2685


<210> 1656
<211> 3198
<212> DNA
<213> Homo sapiens

<400> 1656
ccactggatc ctacaactac tttttccctc ttttgctcac gcacctcgaa gaactggtgc       60

tcccgcggga agcgcacggg gcgcgcaacg aagcgaaagg gcgcggcccc agccgcggga      120

tcccgctcta caggcagcgg ctccgccgcc ccgggccccg cagcgaggcg ggcgcacagc      180

gcggggggca actgcatcac cccgggcgcg ggcgggcgca gcctgtcggc caccgtccgc      240

gagccgagcc ggacgtgacg tcacgctcac ttccgccgcc gtcgggggct gcgcgggggc      300

tgtggctccg ggactgcgga gaacatattg tgatgttcgt gcctcagagc taaaactatg      360

agtgaatttc ggattcacca tgacgtcaat gaactgctta gcctgctgcg tgtccacgga      420

ggagatgggg ctgaggtcta cattgacctg cttcaaaaga acaggacccc gtacgtcact      480

accactgtct ctgctcacag tgccaaggtt aaaattgcag agttttctcg tactccagaa      540

gactttctaa agaaatatga tgaactgaaa tctaaaaata caaggaacct tgacccgctg      600

gtgtacctgt tgtcaaagct cacggaagac aaagagactc tgcagtactt acaacagaat      660

gcaaaagaaa gagctgagct tgcagccgct gctgtgggca gcagtaccac cagcatcaac      720

gtccctgccg cggcctccaa gatctccatg caggagcttg aggaactgag gaagcagctt      780

ggcagcgtgg ccacaggctc cacgctgcag cagtctctgg aacttaaaag aaagatgctt      840

cgagacaagc agaacaaaaa aaattcaggc cagcacctcc ccatcttccc agcatgggtg      900

tatgagagac ctgccctgat cggggatttc ctgattggtg ctggcatcag cacagacacc      960

gctttgccga taggcacgtt gcccctggcc tcgcaggagt cggccgtggt ggaggacctg     1020

ctgtacgtgc tggtgggcgt ggacgggagg tacgtcagtg ctcagcccct ggctgggagg     1080

cagagccgga ccttcctcgt ggaccccaac ctggacctgt ccatcaggga gctggtgcac     1140

aggatcctcc cagtggccgc cagctactcc gctgtgacca ggttcattga agagaagtct     1200

tccttcgagt acgggcaggt gaaccacgcc ctggcggccg ccatgcgcac cctggtgaag     1260

gagcacctga ttctggtgtc acagctggag cagctgcaca ggcagggcct cctttcgctg     1320

cagaagctct ggttctacat ccagccagcc atgcgcacca tggacatcct ggcctccctc     1380

gccacctcgg tggacaaagg cgaatgtctt ggggggtcca cgctgagcct gctccacgac     1440

aggagcttca gctacacagg ggacagccag gcgcaggagc tatgcctgta cctaaccaag     1500

gcggccagtg ctccctactt cgaggttctg gagaagtgga tctacagggg catcatccac     1560

gacccataca gtgagtttat ggtcgaggag cacgagctgc ggaaggagag gatccaggag     1620

gattacaacg acaagtactg ggaccagcgg tacaccatcg tccagcagca gatcccgtcc     1680

ttcctgcaga aaatggcgga caagatcctc agcacaggaa aatatctaaa tgtggtcaga     1740

gagtgtggcc atgacgtcac ctgcccggtg gctaaagaga tcatctacac gttaaaagag     1800

cgggcgtatg tggagcagat cgagaaggcg tttaactacg ccagcaaggt gctgctggac     1860

ttcctgatgg aggagaagga gctggtggct cacctcaggt ccatcaagcg ctacttcctc     1920

atggaccagg gcgacttctt cgtgcacttc atggacctcg cggaggagga gctccggaag     1980

ccggtggagg acatcacgcc ccctcgcctg gaagcgctcc tggagctggc gctgcgcatg     2040

agcacggcca acactgaccc cttcaaggac gacctcaaga tcgacctgat gccccatgac     2100

ctcatcactc agctcttgcg cgtcctggcc atcgagacca agcaggagaa ggcgatggcg     2160

cacgccgacc ccacggagct ggcgctgagc ggcctggagg ccttctcttt cgactacatc     2220

gtcaagtggc ccctttcgct catcatcaac aggaaagccc tcactcgcta ccagatgctc     2280

ttcaggcaca tgttctactg caagcacgtg gagcggcagc tctgcagcgt ctggatcagc     2340

aacaaaaccg ccaagcagca ctcgctgcac tccgcccagt ggtttgctgg ggctttcact     2400

ctgcggcagc gaatgctcaa cttcgtccag aatattcaat actacatgat gtttgaagtg     2460

atggaaccga cctggcacat cctggagaaa aacctgaaat ccgcctccaa cattgacgac     2520

gtccttggcc accacacagg cttcctggac acctgcctga aggactgcat gctcaccaac     2580

cccgagctgc tgaaggtctt ctccaagctc atgtctgtgt gcgtcatgtt caccaactgc     2640

atgcagaaat ttacacagag catgaaatta gatggcgagc tgggcgggca gacgctggag     2700

cacagcaccg tcctggggct gcccgcaggg gccgaggagc gggcccggaa ggagctcgcc     2760

aggaagcacc tggctgagca cgcagacact gtgcagctgg tgtccggctt cgaggccacc     2820

atcaacaagt ttgacaagaa cttctcagcc cacctgctgg acctcctggc ccggctgagc     2880

atctatagca ccagtgactg tgagcacggc atggccagcg tcatctccag gcttgacttc     2940

aatggtttct acacggagcg cctggagcgc ctgtctgcag agaggagcca gaaggccacc     3000

ccccaagtgc ctgtcctgcg ggggcccccg gctcctgcac ccagggtcgc agtcaccgca     3060

cagtgagccc tggctgtgac aggaaggaag ggtgtggggt cagcagggac tggtgcaaat     3120

gggtccagaa ttttcaaatc gaatgctctg tgttctgtct ttgcagttta aatataaagc     3180

aggaatgatt gactcagc                                                   3198


<210> 1657
<211> 5089
<212> DNA
<213> Homo sapiens

<400> 1657
ggagaagggg cgcaggtggc cgccatcttg gattgcgaac tgggtcgcta cgcttcacgc       60

caggggcgga gtggcggccc ttctgttacc cgccacacac gtcgccgctg gggactggga      120

aatcagggca tcggagagtg ccacattaat ggatgccatg gctagtccag ggaaagataa      180

ctatagaatg aaaagttata agaataaagc cctaaatcct caagagatgc gtagacgaag      240

agaagaagaa ggaatacagc ttagaaaaca aaaaagagaa gaacagttgt tcaaacgcag      300

aaatgtctat ttgcccagaa atgatgaatc tatgcttgaa agtcctatac aggatccaga      360

tattagttcc actgtaccca ttccagagga agaagttgtt actacagata tggttcagat      420

gattttttct aataatgctg atcaacagct aacagcaaca cagaaattta gaaagctgct      480

ttctaaagaa cctaatccac caatagatca agttatacag aaaccaggag ttgtacagag      540

atttgtgaaa tttcttgaaa gaaatgaaaa ttgcacttta caatttgaag ctgcatgggc      600

attaacaaat atagcatctg gaacttttct gcataccaag gtagtgattg aaactggggc      660

tgttccgatt tttatcaaac ttcttaattc tgaacatgaa gatgttcagg aacaggctgt      720

ttgggcactt ggtaatattg ctggtgacaa tgcagaatgc agagattttg ttttgaattg      780

tgaaatactt ccacctcttt tagagttatt aacaaattca aacagactca caacaacaag      840

aaatgccgtg tgggccctct caaatttatg tagaggcaaa aaccctcctc caaactttag      900

taaggtttca ccttgcttaa atgtcctgtc acgactgttg tttagcagtg acccagatgt      960

gttagcagac gtgtgttggg ccctttctta tctctccgat ggacccaatg ataaaattca     1020

agcagtcatt gattctggag tctgtcgaag attggtggaa cttttgatgc acaatgatta     1080

taaagttgta tcacctgcat taagggcagt tggtaatatt gtgactggtg atgatattca     1140

aacacaggta attttgaatt gttctgcatt accctgtctc ttacatttat tgagtagccc     1200

aaaggagtca attagaaaag aagcctgctg gactgtttct aacatcactg ctggaaatag     1260

agctcagatt caggctgtta tagatgcaaa tatttttcct gttttgattg agattcttca     1320

gaaagcagag tttcgtacca gaaaagaagc agcttgggct ataactaatg caacatcagg     1380

aggtactcca gagcaaataa ggtatttggt agctttaggc tgcattaaac cactttgtga     1440

tcttttgact gttatggact ccaaaatagt ccaagtggct ttaaatggac ttgaaaatat     1500

tttacgtctt ggagaacaag aatctaagca gaatggaata ggcattaatc catactgtgc     1560

tctcattgaa gaagcatatg gtctggataa aattgagttt ttgcaaagcc atgaaaatca     1620

ggaaatttac cagaaggcat ttgatctgat tgaacattac tttggtgtag aagaagatga     1680

ccccagcatt gtacctcagg tggatgaaaa ccaacaacag tttatatttc agcagcagga     1740

agcaccaatg gatggatttc aactttaact tactggagga aaaaaaattt atggctaaaa     1800

agggtagctt caggtaactc ctctttgttg ccaatgtaag aatgtttgtt tttttacata     1860

gaacagtaaa gagaatttga tgcactttta gaaagcaaaa tgaaacaaaa atttccattc     1920

agatgcaacc tttcattgta gtttgttgtt gttttagttt tgttgttgtg cctgtattta     1980

tatcttctat tgtttggatt tttgtatcta tttgtgaata attgaatatg caattattta     2040

gtaatttaag cttgaaaagg agaattttgg tgaagcatta cttagtaatt ctgaattttt     2100

tcaagcattc ttggaaactg cacattagca gtaaacctat tgataattgc attttggcag     2160

taagtcttac acatctaatc tctactaaat ctacctctat cttgaagcag aaataaaaac     2220

aaaaaagctt cagaagcatg aaataatgca aatgctaaat tagaatgtga aaatatttat     2280

taccttaaat tatacatatc actgtgctgt aggttatact ttgcaaaaaa ttgcaacaga     2340

aaacctataa aatttattta taaaacagaa gaaatattat actgataatc cattaaaatg     2400

tggcaattgt gaagggagaa gctgtttttc atgttgaaca cattaaaaag attactttat     2460

aaaatgttta aatatttctg tttttaacat ataagtgcta tgtatattag tatattttgt     2520

atttcaacca aatatgctac catttttgaa atagtgtttt attgtttttc actcattgtt     2580

ttaaagagca tcatgacaga gatgtcatca tgaatctaaa gtagtgctgc atatctaaaa     2640

taataactaa ttatttctct gatttttcag agcagtaatt gaaaagtttc attttctgta     2700

taatagtact agtttaagtt taagtacaag tacaagttta ggtactcgaa tgacaaaatt     2760

accctgaaga aataacctta ttatgtgtta aattgtatta aatgcattta acatttggat     2820

gctaaatgat aatgaaaatt gctaaaggtt ctttaatatg gttcaaatct ataagacttt     2880

tttcttttag taatactcag agggtcattc tgctgcttgt tatgaatcat agattacatt     2940

catgtcagat tgatcaatat gtatgtttta tgatttaaca gcaaaaacct cttcaaacgg     3000

aaaatttgaa agaaaggttt caatagaaaa attatatata tatttataca tatatatgtg     3060

tgtgtgttac tctcacagtt caactactgt tgaactcaat cttttaattt atagttatac     3120

gtaggctatt tatgtgtcca attgtatacc tagaatactt acttaaaact tagtttacaa     3180

ctctttttaa gatgagaact aaggcaattt tgatatgatt catggtctat tctttaaaaa     3240

aagatttcat ttatgatagt atttgtaatg tttctgctgg aaatcagagg cacgttccaa     3300

gaggaaaatg tatataggag tacttttaaa gaatatgtca ctttgtaaat tacatatcat     3360

gaaactaagc ttttgacaag atacttaaaa cctacagctg taaaatacag gtttaaatgg     3420

tgttcgtaat gctgagtgca tctgccagcc cttttttatt attaagtaga agattgtatc     3480

tgtgcccctt ttttcgtagt ggaaggtata tagccgagta taaaatggtt ttcttttgca     3540

ttatctgtat tcaaaaaaca gggtagttat attaaagctt accaaattga tggtgaattt     3600

atcagattaa cctttttgtg gtgcagatgg ttctaagtat caggtgacag ggtattctac     3660

tctttctagt caattaaaat tgataatgca gcatgattca taaactaacc agctgtgcct     3720

ccttttattt tgaggaccct gtagtcacta taataaattt ctaagccaaa tttttcaaac     3780

aagatagttc ttatagaagg agaaataata aatatgtgtg tgttgatgca tgcacacaga     3840

atgacctgtg aaaggaaact taaattttgc cggtaaaaca aacatatctc tacagactgt     3900

gattatactt cataagcatt taaatacagt tttatttatt tccttaaata tattacttgg     3960

gtaattaatt ttagatttga ttgcaaagag cactgtatag cagttgggac cagctcttgg     4020

cttggcttgg cttggcttat tgttaagagt ttattggatc aagactaaca aataactttg     4080

tgatgaaaat tcttcaaaaa tatagctact cttttcaagt ataccattta aaatatttca     4140

tcaggcagag ccctgaccag gaaaaaaaaa aaaaaagaaa gaaagaaaag aaaaaaataa     4200

ataaaatgct ccaaaaagtg ttttcagtag tcttcactgg cccttgtggg aggaaaaata     4260

cttttttaac ttgcttttct aagatttgtt atatttaaat ccaagagaaa ctatgccgaa     4320

aaaaagtgtt ataaagagga atgcatgtag cattaatgca aatatcaaga aaatacttga     4380

aagagtcctt ttcatttatt taattaaatt tggtgtttta ttttgtctga atctgaattt     4440

ctcctattta atctatgcaa ttatgcttgt tttatattta taagcacttg actcactggg     4500

tgtggtcttt ttactgtgtt ttatttcaaa acgttgtttt aagtgatagt gtccttaaat     4560

tttagtgtca tttggtcaac ttactggtaa caccagaaca agaaagcaaa aaagtaataa     4620

attctgctgg cacagaacta acatatcatt tggtaactgt aaaacctatt tgcagttaaa     4680

ggttgattta ttggataagg gactaaaaga agcatatatt acctttgcct ttatattttt     4740

tcttctttta agaaggagca ttatggaaaa ataaatataa agtcttagtg aatttttgtt     4800

atggttctca attcagcaat ctactggctg cttgcgaaac tgtgaaatca aattgttctt     4860

aacctttatt cagtttagtt tatagcatta ctgttttatg aaatgtgaca ttttaggagc     4920

caatataata gagctctaaa aggatagtat atctttaaat tctgactggg gagtaagaag     4980

agaagatatt cttaccctac taaataaacc aacttttgag tagtatgcaa tattatgaaa     5040

tgttacaaca ctatattaaa aataataaaa tattttaaaa ttgcattta                 5089


<210> 1658
<211> 726
<212> DNA
<213> Homo sapiens

<400> 1658
tctgctactc agaggaaggg gcggttggtg cggcctccat tgttcgtgtt ttaaggcgcc       60

atgaggggtg acagaggccg tggtcgtggt gggcgctttg gttccagagg aggcccagga      120

ggagggttca ggccctttgt accacatatc ccatttgact tctatttgtg tgaaatggcc      180

tttccccggg tcaagccagc acctgatgaa acttccttca gtgaggcctt gctgaagagg      240

aatcaggacc tggctcccaa ttctgctgaa caggcatcta tcctttctct ggtgacaaaa      300

ataaacaatg tgattgataa tctgattgtg gctccaggga catttgaagt gcaaattgaa      360

gaagttcgac aggtgggatc ctataaaaag gggacaatga ctacaggaca caatgtggct      420

gacctggtgg tgatactcaa gattctgcca acgtgtgagt gtgcctgttt ctggtcatgg      480

gaacagaaca tagcacttgg attaggggtt taggtatctt tttttgtttt gagacaaatt      540

ctccctccgt tggccaggct ggagtgcagt ggtaccattg tagctcactg cagccttgac      600

ctccactaca gcaagtgatc ttcccgcctt agcctcccga gtagctggga ctacagatgt      660

gtgctaccac acccagctaa tttttgtatt ttttgtagat acagggtttc accgtgttgc      720

tcgggc                                                                 726


<210> 1659
<211> 476
<212> DNA
<213> Homo sapiens

<400> 1659
aggggtgaca gaggccgtgg tcgtggtggg cgctttggtt ccagaggagg cccaggagga       60

gggttcaggc cctttgtacc acatatccca tttgacttct atttgttgtt tacttctggt      120

ttagtgtgaa atggcctttc cccgggtcaa gccagcacct gatgaaactt ccttcagtga      180

ggccttgctg aagaggaatc aggacctggc tcccaattct gctgaacagg catctatcct      240

ttctctggtg acaaaaataa acaatgtgat tgataatctg attgtggctc cagggacatt      300

tgaagtgcaa attgaagaag ttcgacaggt gggatcctat aaaaagggga caatgactac      360

aggacacaat gtggctgacc tggtggtgat actcaagatt ctgccaacgt tggaagctgt      420

tgctgccctg gggaacaaag tcgtggaaag cctaagagca caggatcctt ctgaag          476


<210> 1660
<211> 947
<212> DNA
<213> Homo sapiens

<400> 1660
ctctgttccc cttttcctgc caccttcttc tccagggacc agaaacaagg gccccgccag       60

caggcgaagc agggagatgt cagactgcta cacggagctg gagaaggcag tcattgtcct      120

ggtggaaaac ttctacaaat atgtgtctaa gtacagcctg gtcaagaaca agatcagcaa      180

gagcagcttc cgcgagatgc tccagaaaga gctgaaccac atgctgtcgg acacagggaa      240

ccggaaggct gcggataagc tcatccagaa cctggatgcc aatcatgatg ggcgcatcag      300

cttcgatgag tactggacct tgataggcgg catcaccggc cccatcgcca aactcatcca      360

tgagcaggag cagcagagca gcagctagag acccctttgg ccacaccttc caggcactgg      420

cctgatgccc cgccctggtg ctctccccag gctccctcct cagcctcctg cccacccagg      480

gccctttact ctcttctccc tccagacctt cctctgaccc ttgctgaact ggggtccctt      540

tgtgagtgtc tcagtctaga ggtacctccc tccctggggg gtctcagctc ctggagtcgc      600

aggcccttgg ggcccctctg tgagatctca atgctgtctg gggaccctaa gagttttctc      660

acctgttcag tctcatctaa ccttccaatg tctgatgttc ctgccaaatt cctgcctgat      720

tctgggtccg tcctgacctc caaaggtcag cttggtgctt gaggtctccc tgctcttggt      780

ggcagtggta gcagcaacag cagcagcagc agcagcagca gcagcagaga cctctccact      840

ttcccttagc ccctctgctg ggtagagagg cactttcagg gacttccctc cagctgcctc      900

ttcatctggg aatgagctaa gcaaggctga gcctcctcct gttgctt                    947


<210> 1661
<211> 1146
<212> DNA
<213> Homo sapiens

<400> 1661
aatggccaca agtggccaac ggaaagcagg tggcaggaca ggaggctgtg gtggggcctg       60

accgagcagc ctttccttcc aaatctgact gtggcttgct caggccccta tggtggctgt      120

gaccctgttt tgtccatctc ctttcaccag gacccgccgg gccccgccag caggcgaagc      180

agggagatgt cagactgcta cacggagctg gagaaggcag tcattgtcct ggtggaaaac      240

ttctacaaat atgtgtctaa gtacagcctg gtcaagaaca agatcagcaa gagcagcttc      300

cgcgagatgc tccagaaaga gctgaaccac atgctgtcgg acacagggaa ccggaaggct      360

gcggataagc tcatccagaa cctggatgcc aatcatgatg ggcgcatcag cttcgatgag      420

tactggacct tgataggcgg catcaccggc cccatcgcca aactcatcca tgagcaggag      480

cagcagagca gcagctagag acccctttgg ccacaccttc caggcactgg cctgatgccc      540

cgccctggtg ctctccccag gctccctcct cagcctcctg cccacccagg gccctttact      600

ctcttctccc tccagacctt cctctgaccc ttgctgaact ggggtccctt tgtgagtgtc      660

tcagtctaga ggtacctccc tccctggggg gtctcagctc ctggagtcgc aggcccttgg      720

ggcccctctg tgagatctca atgctgtctg gggaccctaa gagttttctc acctgttcag      780

tctcatctaa ccttccaatg tctgatgttc ctgccaaatt cctgcctgat tctgggtccg      840

tcctgacctc caaaggtcag cttggtgctt gaggtctccc tgctcttggt ggcagtggta      900

gcagcaacag cagcagcagc agcagcagca gcagcagaga cctctccact ttcccttagc      960

ccctctgctg ggtagagagg cactttcagg gacttccctc cagctgcctc ttcatctggg     1020

aatgagctaa gcaaggctga gcctcctcct gttgcttgaa ataatgatga tataaaggct     1080

ggatttggag tttgtatccc ctggtccctc tgggatgctc attaaaacct tcccactcct     1140

tggaaa                                                                1146


<210> 1662
<211> 1443
<212> DNA
<213> Homo sapiens

<400> 1662
agccggcatg ggagtaggaa tggccacaag tggccaacgg aaagcaggtg gcaggacagg       60

aggctgtggt ggggcctgac cgagcagcct ttccttccaa atctgactgt ggcttgctca      120

ggcccctatg gtggctgtga ccctgttttg tccatctcct ttcaccagga cccgccgggt      180

gagggtgact ggagcacatt cctgggcttg ggggtgggaa gggagtctga tttgcctggg      240

gttgatgtgg gggggttttg ggcatgggcc gtgactcaca gagtagatcc agatccgcct      300

gctcccctca tatcctgtta ttcagaaggc tgtatccgct tagaaagtgt cttttgtcct      360

ggggtgagag ggtgacgcat gtgccctctg gcagtctgct gctgtgtcca gagtccgact      420

ccagctgggc tgtaactggg cttggccccc gccttaggcc ccgccagcag gcgaagcagg      480

gagatgtcag actgctacac ggagctggag aaggcagtca ttgtcctggt ggaaaacttc      540

tacaaatatg tgtctaagta cagcctggtc aagaacaaga tcagcaagag cagcttccgc      600

gagatgctcc agaaagagct gaaccacatg ctgtcggaca cagggaaccg gaaggctgcg      660

gataagctca tccagaacct ggatgccaat catgatgggc gcatcagctt cgatgagtac      720

tggaccttga taggcggcat caccggcccc atcgccaaac tcatccatga gcaggagcag      780

cagagcagca gctagagacc cctttggcca caccttccag gcactggcct gatgccccgc      840

cctggtgctc tccccaggct ccctcctcag cctcctgccc acccagggcc ctttactctc      900

ttctccctcc agaccttcct ctgacccttg ctgaactggg gtccctttgt gagtgtctca      960

gtctagaggt acctccctcc ctggggggtc tcagctcctg gagtcgcagg cccttggggc     1020

ccctctgtga gatctcaatg ctgtctgggg accctaagag ttttctcacc tgttcagtct     1080

catctaacct tccaatgtct gatgttcctg ccaaattcct gcctgattct gggtccgtcc     1140

tgacctccaa aggtcagctt ggtgcttgag gtctccctgc tcttggtggc agtggtagca     1200

gcaacagcag cagcagcagc agcagcagca gcagagacct ctccactttc ccttagcccc     1260

tctgctgggt agagaggcac tttcagggac ttccctccag ctgcctcttc atctgggaat     1320

gagctaagca aggctgagcc tcctcctgtt gcttgaaata atgatgatat aaaggctgga     1380

tttggagttt gtatcccctg gtccctctgg gatgctcatt aaaaccttcc cactccttgg     1440

aaa                                                                   1443


<210> 1663
<211> 1203
<212> DNA
<213> Homo sapiens

<400> 1663
tttaacaagg gcccaacccc agggccaagt caagaaggag ctcagccact atctccccac       60

cgagccagct cagcgggcag ggctgggagg gagtgggaca gattctggga gtgcagcggg      120

gaggagtccc ggctgggctg agcgcaggga gctgcttggc agtgccagag cccaggcccc      180

agagccctgc tggagaggag gcagactgag gcagcaggcc ccgccagcag gcgaagcagg      240

gagatgtcag actgctacac ggagctggag aaggcagtca ttgtcctggt ggaaaacttc      300

tacaaatatg tgtctaagta cagcctggtc aagaacaaga tcagcaagag cagcttccgc      360

gagatgctcc agaaagagct gaaccacatg ctgtcggaca cagggaaccg gaaggctgcg      420

gataagctca tccagaacct ggatgccaat catgatgggc gcatcagctt cgatgagtac      480

tggaccttga taggcggcat caccggcccc atcgccaaac tcatccatga gcaggagcag      540

cagagcagca gctagagacc cctttggcca caccttccag gcactggcct gatgccccgc      600

cctggtgctc tccccaggct ccctcctcag cctcctgccc acccagggcc ctttactctc      660

ttctccctcc agaccttcct ctgacccttg ctgaactggg gtccctttgt gagtgtctca      720

gtctagaggt acctccctcc ctggggggtc tcagctcctg gagtcgcagg cccttggggc      780

ccctctgtga gatctcaatg ctgtctgggg accctaagag ttttctcacc tgttcagtct      840

catctaacct tccaatgtct gatgttcctg ccaaattcct gcctgattct gggtccgtcc      900

tgacctccaa aggtcagctt ggtgcttgag gtctccctgc tcttggtggc agtggtagca      960

gcaacagcag cagcagcagc agcagcagca gcagagacct ctccactttc ccttagcccc     1020

tctgctgggt agagaggcac tttcagggac ttccctccag ctgcctcttc atctgggaat     1080

gagctaagca aggctgagcc tcctcctgtt gcttgaaata atgatgatat aaaggctgga     1140

tttggagttt gtatcccctg gtccctctgg gatgctcatt aaaaccttcc cactccttgg     1200

aaa                                                                   1203


<210> 1664
<211> 4295
<212> DNA
<213> Homo sapiens

<400> 1664
gcttggggtg cagggcagcc caggctggct actggctgga agatctgctt tggaaagctt       60

tttgaaagca aagatgagca acactcaagc tgagaggtcc ataataggca tgatcgacat      120

gtttcacaaa tacaccggac gtgatggcaa gattgagaag ccaagcctgc tgacgatgat      180

gaaggagaac ttccccaatt tcctcagtgc ctgtgacaaa aagggcatac attacctcgc      240

cactgtcttt gagaaaaagg acaagaatga ggataagaag attgattttt ctgagtttct      300

gtccttgctg ggagacatag ccgcagacta ccacaagcag agccatggag cggcgccctg      360

ttctggggga agccagtgat ccagccccac caaggggcct ccagagaccc caggaacaat      420

aagtgtctcc tcccaccaga cacttgcctt atttcttctt ctctttggtg acctacattg      480

tcaaaactac caattccagg ttaactttgt tggagaattt cccccacccc catccagtgg      540

gtcacccagg agtaatgtcc ctccagcaac gttcccccta tggcctccag cagagctgat      600

ctgcctctca cacaggtcct ggtgtctgcc tctgcaccgt tccctaaatg cagccacctt      660

ggcaggttcc aggtggaagt tggtagaagg cccctgccag gtcacagcaa tgctctcctt      720

gtcaaggcat ggaccagggt cattcagaca cattcagata ctgcactgag aaggagctgg      780

catctctcag tgtgctcctg ccctcccact cctgccccag ctgttctcca gggcttgggg      840

aaacagaaac cactcacata gggattcctg gatggcttca ggttcagcgc ccttggggct      900

atgaatggga ggctcagcag tgccctgagg atgggcttcc ttgtcctgtg gcctctgctc      960

caggggcagt gtcctttccc tgtgctgtgt gcttgtgtgc atgtgcctat gtgggtgacc     1020

ctgtggaagt gagaaggagt cactgtgatg cttagctgtc ctaaatgatg gtttgctcaa     1080

tgccaggact gggtttctgg tgatgaatga atattccaga ttttgaggag ctctaagtgg     1140

tccaggagtc caagtaagca gtctggctgg aataaggcag catcacggaa attctgtaag     1200

gactgacaca gagagctcat gctgactgtg atgagaaatt gcagcacctc tatctcgcag     1260

gtaatggagt agtttgttat tggtagtcta ctccaggcca ggcagtgtgt tatgggctga     1320

ggatgcagaa acaggcagga cacagtgctg tcctagcagt gcactggcgg gtctctccat     1380

gcaggccaca acacagggtc agtgttcacc tggtgtcact tccaggcaat gttctgtgca     1440

gccgctctta gtattcttcc ttgaggctca catcatgtgt ccctatcact cttactactc     1500

tggtcagtct ccagctaacc tctcaatcag gcaaacattc ttcttggagg aatcaggcaa     1560

acatctcaaa aattctcttt ccatcctacc agcagcagtg tgtaagatgg gctatttgtt     1620

ctttggaatg actgctccac tccacactca cacctctatt cacagaccag catctcctct     1680

ccttatcagg aacattcctt cctgaacata ttctgcacct cgtcagcctt caggactgat     1740

ctgccatttt cacctctaaa tccccatgtc tgaccattag ttttcttctc tttccttctc     1800

tccctttctc attctcattc cacctgttct tggaactcac ggagacctac agtccctggg     1860

ctttcatttt ctcctcccag ccccctgctg ccttctctat gcagcctgcc ctccatcatc     1920

caccccagaa ttgctctctt tcctctctta gctctgttgc ccactttcct tgggccatac     1980

cttccctgca gatctccagc ccagaaccat cttcccctgt tgtcctcctc tctcctccac     2040

cgggactgct ggtcactgct tagaaccgtc atgccagggt cccaaaagtg tgggtgcctg     2100

acttcctctc tgtgcagcac tctctgaatc cctcctattc accttgctgc tgttattccc     2160

cgaatgcgca acataccccc catcaatata tctcagtatt tcatgtctca ataccaatct     2220

tttaaactac tgcctctacc agaaatgtct tttaatactt cttctgtctc attaacatta     2280

catttcaagg ctgagcttta atgtcagtgt ctcttagaca ttcagagggt gaaccaccat     2340

cccttcaccc caaagaaatg atctctgctt catttgtgcc tccctcacca tgaccccact     2400

cttaccatag tggctacatt acttcagatt cccctaatgt ctttccagcc agacttggaa     2460

tcatggaggg aaaacattgt tacctcggat ctcctggtta cccagcacat agtagtactg     2520

gattccagct cataataagt actctatatc atttttcaat ataaaatgta tttgtgcaaa     2580

ttctagtcaa tactacttta tgtaaacagc agtgtaaaat ccaaaaactt ccagtcctgg     2640

aggcaggttg tgcagcttag gggaggaccc cagaatctgg accccagagt ctggaagcag     2700

gccagaaagg ataaggcaaa tgactgaaca gttccctcag gactcacgta ctgatctccc     2760

aaaagaagag agggtctccc tggggtgggg ttgctggacc ttcaatccat cgctacagtc     2820

cagaaggcaa ttggccactc ctaatgtggg cctgccctcc ctttattttt ccagttctta     2880

tttcacctga taatattccg tccaattggc aatggcacat aaaaattagg atggagtgtg     2940

tggacaaata cttcttcatc ttcttgtcta ggttttagaa atcaccttct caagggagcc     3000

ttgtctaatg ttcctgagac tatttcacac tctccatgct tatgtcaatg caggactcat     3060

cacatctatt cggatattct gtttacacac ccatgtcatc ccagagaggt gatcacaggg     3120

cagggacaca tgtgtggcat acagttccta gttaagatcc caaatcctga gatattgctg     3180

atttgctatg gcaggtcgtc aagagaactg tgtcattcca aactcaccaa ggtggcttat     3240

agaacagaag cagatggata tgaagaggag aggggaccag accatctccg caaccacagc     3300

ccagagctcc agtcaccaga tagaaaattg atttgatttc atccaatatt ccttcgaaag     3360

agtgtcaagg aatagggtgg ggcaatgtgt cattctgcat tggaaggagg acattttaga     3420

gcaaggccta agggcacagg tattagtgtc atattgatca gaattcaacc tttgttctaa     3480

cacatactag agcaagaatt tacttgattt ggaataatta atagctactg gacattatat     3540

tggtactaaa gagaaagaat acttgacagc tctatgccca cactcacatt acagctgatg     3600

tgaaagagat tctggaaatc caaatgttcc ccagaaattc tgatatcaaa acattccaat     3660

aacttttttt tttcaggcgc agtctcactc tgtcgcccgg gctggagtgc tgtgagctgt     3720

ccgtggtgct gaattcactg tgacgtcact cctgtctctc tttgctttct tctgactgac     3780

atttattcag ccttctctac aggaatctct tatgttcccc cacatgcagg tggtttttca     3840

gtaggctcct gaagagtgat ctcaactttc caggaagaaa agagggcaaa gggaacaatg     3900

tgaaaagaag cagaaaatca taaaagacca tgtgtttgat aaacaaccag attgtttctg     3960

gttccctgcc actataaaaa caccatgaga gcatactcat acatgttccc ttataaatct     4020

gcgaggtagt ttctttggta ttcttgccca ggaaatgggt tgattcatca cagattttat     4080

atatatactt ttttttaact aagtgtgaga taatatctta ttgtttttgt aacttgcatt     4140

ttacaagagt tctgaccagc accagataag cttcagtgct ctcctttctt tggccttaat     4200

attattggat taaagaatta ctgcctctca ctaggagcat catttattta ccattatttt     4260

caatttcata ttaaaactca atttctagta gagtc                                4295


<210> 1665
<211> 4334
<212> DNA
<213> Homo sapiens

<400> 1665
gtgggaagag ccaggctgag ccttataaag gactgctctt tgtccaaaca cacacatctc       60

actcatcctt ctactcgtga cacttcccag ttctggcttt ttgaaagcaa agatgagcaa      120

cactcaagct gagaggtcca taataggcat gatcgacatg tttcacaaat acaccggacg      180

tgatggcaag attgagaagc caagcctgct gacgatgatg aaggagaact tccccaattt      240

cctcagtgcc tgtgacaaaa agggcataca ttacctcgcc actgtctttg agaaaaagga      300

caagaatgag gataagaaga ttgatttttc tgagtttctg tccttgctgg gagacatagc      360

cgcagactac cacaagcaga gccatggagc ggcgccctgt tctgggggaa gccagtgatc      420

cagccccacc aaggggcctc cagagacccc aggaacaata agtgtctcct cccaccagac      480

acttgcctta tttcttcttc tctttggtga cctacattgt caaaactacc aattccaggt      540

taactttgtt ggagaatttc ccccaccccc atccagtggg tcacccagga gtaatgtccc      600

tccagcaacg ttccccctat ggcctccagc agagctgatc tgcctctcac acaggtcctg      660

gtgtctgcct ctgcaccgtt ccctaaatgc agccaccttg gcaggttcca ggtggaagtt      720

ggtagaaggc ccctgccagg tcacagcaat gctctccttg tcaaggcatg gaccagggtc      780

attcagacac attcagatac tgcactgaga aggagctggc atctctcagt gtgctcctgc      840

cctcccactc ctgccccagc tgttctccag ggcttgggga aacagaaacc actcacatag      900

ggattcctgg atggcttcag gttcagcgcc cttggggcta tgaatgggag gctcagcagt      960

gccctgagga tgggcttcct tgtcctgtgg cctctgctcc aggggcagtg tcctttccct     1020

gtgctgtgtg cttgtgtgca tgtgcctatg tgggtgaccc tgtggaagtg agaaggagtc     1080

actgtgatgc ttagctgtcc taaatgatgg tttgctcaat gccaggactg ggtttctggt     1140

gatgaatgaa tattccagat tttgaggagc tctaagtggt ccaggagtcc aagtaagcag     1200

tctggctgga ataaggcagc atcacggaaa ttctgtaagg actgacacag agagctcatg     1260

ctgactgtga tgagaaattg cagcacctct atctcgcagg taatggagta gtttgttatt     1320

ggtagtctac tccaggccag gcagtgtgtt atgggctgag gatgcagaaa caggcaggac     1380

acagtgctgt cctagcagtg cactggcggg tctctccatg caggccacaa cacagggtca     1440

gtgttcacct ggtgtcactt ccaggcaatg ttctgtgcag ccgctcttag tattcttcct     1500

tgaggctcac atcatgtgtc cctatcactc ttactactct ggtcagtctc cagctaacct     1560

ctcaatcagg caaacattct tcttggagga atcaggcaaa catctcaaaa attctctttc     1620

catcctacca gcagcagtgt gtaagatggg ctatttgttc tttggaatga ctgctccact     1680

ccacactcac acctctattc acagaccagc atctcctctc cttatcagga acattccttc     1740

ctgaacatat tctgcacctc gtcagccttc aggactgatc tgccattttc acctctaaat     1800

ccccatgtct gaccattagt tttcttctct ttccttctct ccctttctca ttctcattcc     1860

acctgttctt ggaactcacg gagacctaca gtccctgggc tttcattttc tcctcccagc     1920

cccctgctgc cttctctatg cagcctgccc tccatcatcc accccagaat tgctctcttt     1980

cctctcttag ctctgttgcc cactttcctt gggccatacc ttccctgcag atctccagcc     2040

cagaaccatc ttcccctgtt gtcctcctct ctcctccacc gggactgctg gtcactgctt     2100

agaaccgtca tgccagggtc ccaaaagtgt gggtgcctga cttcctctct gtgcagcact     2160

ctctgaatcc ctcctattca ccttgctgct gttattcccc gaatgcgcaa catacccccc     2220

atcaatatat ctcagtattt catgtctcaa taccaatctt ttaaactact gcctctacca     2280

gaaatgtctt ttaatacttc ttctgtctca ttaacattac atttcaaggc tgagctttaa     2340

tgtcagtgtc tcttagacat tcagagggtg aaccaccatc ccttcacccc aaagaaatga     2400

tctctgcttc atttgtgcct ccctcaccat gaccccactc ttaccatagt ggctacatta     2460

cttcagattc ccctaatgtc tttccagcca gacttggaat catggaggga aaacattgtt     2520

acctcggatc tcctggttac ccagcacata gtagtactgg attccagctc ataataagta     2580

ctctatatca tttttcaata taaaatgtat ttgtgcaaat tctagtcaat actactttat     2640

gtaaacagca gtgtaaaatc caaaaacttc cagtcctgga ggcaggttgt gcagcttagg     2700

ggaggacccc agaatctgga ccccagagtc tggaagcagg ccagaaagga taaggcaaat     2760

gactgaacag ttccctcagg actcacgtac tgatctccca aaagaagaga gggtctccct     2820

ggggtggggt tgctggacct tcaatccatc gctacagtcc agaaggcaat tggccactcc     2880

taatgtgggc ctgccctccc tttatttttc cagttcttat ttcacctgat aatattccgt     2940

ccaattggca atggcacata aaaattagga tggagtgtgt ggacaaatac ttcttcatct     3000

tcttgtctag gttttagaaa tcaccttctc aagggagcct tgtctaatgt tcctgagact     3060

atttcacact ctccatgctt atgtcaatgc aggactcatc acatctattc ggatattctg     3120

tttacacacc catgtcatcc cagagaggtg atcacagggc agggacacat gtgtggcata     3180

cagttcctag ttaagatccc aaatcctgag atattgctga tttgctatgg caggtcgtca     3240

agagaactgt gtcattccaa actcaccaag gtggcttata gaacagaagc agatggatat     3300

gaagaggaga ggggaccaga ccatctccgc aaccacagcc cagagctcca gtcaccagat     3360

agaaaattga tttgatttca tccaatattc cttcgaaaga gtgtcaagga atagggtggg     3420

gcaatgtgtc attctgcatt ggaaggagga cattttagag caaggcctaa gggcacaggt     3480

attagtgtca tattgatcag aattcaacct ttgttctaac acatactaga gcaagaattt     3540

acttgatttg gaataattaa tagctactgg acattatatt ggtactaaag agaaagaata     3600

cttgacagct ctatgcccac actcacatta cagctgatgt gaaagagatt ctggaaatcc     3660

aaatgttccc cagaaattct gatatcaaaa cattccaata actttttttt ttcaggcgca     3720

gtctcactct gtcgcccggg ctggagtgct gtgagctgtc cgtggtgctg aattcactgt     3780

gacgtcactc ctgtctctct ttgctttctt ctgactgaca tttattcagc cttctctaca     3840

ggaatctctt atgttccccc acatgcaggt ggtttttcag taggctcctg aagagtgatc     3900

tcaactttcc aggaagaaaa gagggcaaag ggaacaatgt gaaaagaagc agaaaatcat     3960

aaaagaccat gtgtttgata aacaaccaga ttgtttctgg ttccctgcca ctataaaaac     4020

accatgagag catactcata catgttccct tataaatctg cgaggtagtt tctttggtat     4080

tcttgcccag gaaatgggtt gattcatcac agattttata tatatacttt tttttaacta     4140

agtgtgagat aatatcttat tgtttttgta acttgcattt tacaagagtt ctgaccagca     4200

ccagataagc ttcagtgctc tcctttcttt ggccttaata ttattggatt aaagaattac     4260

tgcctctcac taggagcatc atttatttac cattattttc aatttcatat taaaactcaa     4320

tttctagtag agtc                                                       4334


<210> 1666
<211> 568
<212> DNA
<213> Homo sapiens

<400> 1666
agatctttga agactctgat tctctgagac tgaggagaga tgtcttacca gcagcagcag       60

tgcaagcagc cctgccagcc acctcctgtg tgccccacgc caaagtgccc agagccatgt      120

ccacccccga agtgccctga gccttacctg cctcctcctt gtccacctga gcattgccca      180

cctccaccat gccaggataa atgccctcct gtgcaaccat acccaccctg ccagcagaag      240

tatccaccca agagcaagta acatcactag aattcatcag gaccatgaaa caacaagatc      300

cagtggctct tcttactccc aggactccat catcttccct tcagctgtag tgggaggctg      360

catcttccct aacctctgtc tggcttgagc gttgacagag aaaaggctta gttctgaaaa      420

ccgatatgtt gttggaagat gagcagccag atcactgcct aatctcgctt tgctgtctgt      480

gatgtagatg gtggttccta tcctgagagc aagtgtgttt attcttttgc ttctccccaa      540

taaagcacat gtttcatggt caagccca                                         568


<210> 1667
<211> 678
<212> DNA
<213> Homo sapiens

<400> 1667
aaactcctgg tacttgagca ctgatctgct ttggagaacc tgattctgag actccagcag       60

gatgtcttat caacagcagc agtgcaagca gccctgccag ccacctcctg tgtgccccac      120

gccaaagtgc ccagagccat gtccaccccc gaagtgccct gagccctgcc caccaccaaa      180

gtgtccacag ccctgcccac ctcagcagtg ccagcaaaaa tgtcctcctg tgacaccttc      240

cccaccctgc cagccaaagt gtccacccaa gagcaagtaa cagcttcaga attcatcagg      300

agcatgaaag gataaggata attggctcac cttgttccac agcttcacct gcatcttctc      360

atcaaagcct accatggata cacagttagc ttctttcctc ttagccagtg atctgcccat      420

gatgatccct gatagcaaaa ggtttccttt ctgaggctgc catattgcca ctgtccaggt      480

ggagactgag aaaggaagtc ctcagcagtg tcagttccca gagctttgga agaaggacca      540

gcagctctgt ccctgggaac catcaaaaaa tgctgttgat gttttctgtg tctgtctgtc      600

acctgggcat gggcttctaa cacctgtgca attgtcactt ttctttcact ccctgaataa      660

aatatctttg catacgta                                                    678


<210> 1668
<211> 692
<212> DNA
<213> Homo sapiens

<400> 1668
gaaagtgtct gttcttgtct tttgttcact tttcaaaggg gctgtttatt tttcatattc       60

tgagactcca gcaggatgtc ttatcaacag cagcagtgca agcagccctg ccagccacct      120

cctgtgtgcc ccacgccaaa gtgcccagag ccatgtccac ccccgaagtg ccctgagccc      180

tgcccaccac caaagtgtcc acagccctgc ccacctcagc agtgccagca aaaatgtcct      240

cctgtgacac cttccccacc ctgccagcca aagtgtccac ccaagagcaa gtaacagctt      300

cagaattcat caggagcatg aaaggataag gataattggc tcaccttgtt ccacagcttc      360

acctgcatct tctcatcaaa gcctaccatg gatacacagt tagcttcttt cctcttagcc      420

agtgatctgc ccatgatgat ccctgatagc aaaaggtttc ctttctgagg ctgccatatt      480

gccactgtcc aggtggagac tgagaaagga agtcctcagc agtgtcagtt cccagagctt      540

tggaagaagg accagcagct ctgtccctgg gaaccatcaa aaaatgctgt tgatgttttc      600

tgtgtctgtc tgtcacctgg gcatgggctt ctaacacctg tgcaattgtc acttttcttt      660

cactccctga ataaaatatc tttgcatacg ta                                    692


<210> 1669
<211> 788
<212> DNA
<213> Homo sapiens

<400> 1669
ctgtagtaca catccttgat ggcaccaagt agcaaacgtg ctgtggagac tagatctcac       60

tctcaaatct gtcctgggat gcaagtgcct ctacgaatgt ggtgcagaag ctacaaatgt      120

ggtgcagaag acagcttcaa agaggaaagg aatataggtg ccaagagcct gcaatccttc      180

ccaaacagcc ctttgttctg tgctcaagtc aacccactgg gactttacta cagataatga      240

taagagaaat ggcttgtgag attgctcatg atcctgagac tccagcagga tgtcttatca      300

acagcagcag tgcaagcagc cctgccagcc acctcctgtg tgccccacgc caaagtgccc      360

agagccatgt ccacccccga agtgccctga gccctgccca tcaccaaagt gtccacagcc      420

ctgcccacct cagcagtgcc agcagaaata tcctcctgtg acaccttccc caccctgcca      480

gccaaagtgt ccacccaaga gcaagtaaca gcttcaggat tcatcaggag catgagagga      540

taaggataat tggctcacct cgttccacag ctccacttgc atcttctcac caaagccttc      600

catggatgca cagggagctt ctttctcctt aacctgtggc ctgcctgtga tgatctgtga      660

cagcaaaaga ttccctttct gaggctgcca tactgccact gtccaggtgg agctaagaaa      720

aggaagtcct cagctgtgcc agctcccaga gcttcggaag aaagagcagc agctctctcc      780

ctgggaac                                                               788


<210> 1670
<211> 800
<212> DNA
<213> Homo sapiens

<400> 1670
aggctgtagt acacatcctt gatggcacca agtagcaaac gtgctgtgga gactagatct       60

cactctcaaa tctgtcctgg gatgcaagtg cctctacgaa tgtggtgcag aagctacaaa      120

tgtggtgcag aagacagctt caaagaggaa aggaatatag gtaaaaatct gaggttttat      180

ctgagaaaaa ggtggcaaag aaaatttcag tcttgaacag ggtcagcaga tagcacaatg      240

tggtcagcct gcaaacccag agatcctgag actccagcag gatgtcttat caacagcagc      300

agtgcaagca gccctgccag ccacctcctg tgtgccccac gccaaagtgc ccagagccat      360

gtccaccccc gaagtgccct gagccctgcc catcaccaaa gtgtccacag ccctgcccac      420

ctcagcagtg ccagcagaaa tatcctcctg tgacaccttc cccaccctgc cagccaaagt      480

gtccacccaa gagcaagtaa cagcttcagg attcatcagg agcatgagag gataaggata      540

attggctcac ctcgttccac agctccactt gcatcttctc accaaagcct tccatggatg      600

cacagggagc ttctttctcc ttaacctgtg gcctgcctgt gatgatctgt gacagcaaaa      660

gattcccttt ctgaggctgc catactgcca ctgtccaggt ggagctaaga aaaggaagtc      720

ctcagctgtg ccagctccca gagcttcgga agaaagagca gcagctctct ccctgggaac      780

catcagacaa ttctgttgat                                                  800


<210> 1671
<211> 782
<212> DNA
<213> Homo sapiens

<400> 1671
aggctgtagt acacatcctt gatggcacca agtagcaaac gtgctgtgga gactagatct       60

cactctcaaa tctgtcctgg gatgcaagtg cctctacgaa tgtggtgcag aagctacaaa      120

tgtggtgcag aagacagctt caaagaggaa aggaatatag atcctgagac tccagcagga      180

tgtcttatca acagcagcag tgcaagcagc cctgccagcc acctcctgtg tgccccacgc      240

caaagtgccc agagccatgt ccacccccga agtgccctga gccctgccca tcaccaaagt      300

gtccacagcc ctgcccacct cagcagtgcc agcagaaata tcctcctgtg acaccttccc      360

caccctgcca gccaaagtgt ccacccaaga gcaagtaaca gcttcaggat tcatcaggag      420

catgagagga taaggataat tggctcacct cgttccacag ctccacttgc atcttctcac      480

caaagccttc catggatgca cagggagctt ctttctcctt aacctgtggc ctgcctgtga      540

tgatctgtga cagcaaaaga ttccctttct gaggctgcca tactgccact gtccaggtgg      600

agctaagaaa aggaagtcct cagctgtgcc agctcccaga gcttcggaag aaagagcagc      660

agctctctcc ctgggaacca tcagacaatt ctgttgatgt gttctgtgtc tgtctgtcac      720

ctggtcatga gcttctacca cctttgcaat tgtcatttat ctttcactcc ctgaataaag      780

ta                                                                     782


<210> 1672
<211> 9623
<212> DNA
<213> Homo sapiens

<400> 1672
accctgaaag ctgtttctgt ctctacccta cttgttcctc tggtgagcta ggttactcaa       60

acttgcaaaa aaaaaaatgc ctaaactcct acaaggcgtc atcactgtca tcgatgtttt      120

ctaccaatat gccacccagc atggggagta tgatacgttg aacaaggcag agctgaaaga      180

acttctggaa aatgagtttc atcaaattct gaagaatcca aacgatccag atactgtgga      240

tatcatcttg caaagtctgg atcgagacca taacaagaaa gtggatttta ctgagtatct      300

tctgatgata ttcaagctgg ttcaggctcg taataaaatc attggcaaag attactgcca      360

agtttcaggg tcaaagctga gagatgacac tcaccagcac caagaggaac aagaagaaac      420

tgaaaaagag gagaacaaac ggcaagaatc ctcttttagt cattcaagtt ggagtgcagg      480

agagaatgat tcctattcca gaaacgtcag aggaagtctt aaacctggga ctgaatccat      540

atccagaaga ctgagttttc aaagagactt ttctggccaa cataactcct actcaggtca      600

gtcttccagc tatggtgagc aaaactccga ctcccatcag tcttcaggcc gcggccaatg      660

tgggtctggg tcagggcagt ctcccaacta tggccaacac ggctctggct ccggacagtc      720

ttccagcaat gacacacatg ggtctggctc aggccagtct tctggcttta gtcaacacaa      780

gtctagctca gggcagtcct ctggttacag tcagcatgga tctggctcag gtcactcctc      840

tggctacgga caacacggct ctaggtcagg acagtcatct aggggtgaac gacacagatc      900

tagctcaggt tcgtcttcca gctatggtca gcatgggtct ggttcccgtc agtctttggg      960

ccacggccga caagggtctg gatctcgcca gtctcctagc cacgtccgac atgggtccgg     1020

ttcggggcac tcctccagcc acggccaaca cgggtctggc tcaagttact cttacagccg     1080

tggccattat gagtctggct caggccagac ttctggcttt gggcaacatg agtctggctc     1140

aggacagtcc tctggctata gtaagcatgg ttctggctca ggtcactcct ctagccaggg     1200

acaacatgga tctacgtcag ggcaggcatc aagctctggc caacatggct ccagctcacg     1260

tcagtcttcc agctatggtc agcatgagtc tgcctcccgt cactcttcag gccgcggcca     1320

acacagctct ggatctggcc agtctccagg ccacggccag cgtgggtctg ggtcagggca     1380

gtctcccagc tccggccaac atgggactgg ctttggtcga tcttccagca gtggcccata     1440

tgtgtctggt tcaggctact cttctggctt tggtcaccac gagtctagct cagagcattc     1500

ctctggttac actcagcatg gatctggctc aggtcactcc tccggccacg gacaacacgg     1560

ctctaggtca ggacagtcat ctaggggtga acgacaagga tctagtgcag gttcatcttc     1620

cagctatggt cagcatgggt ctggctcccg tcaatctttg ggacacagcc gacatgggtc     1680

tggatctggc cagtctccta gccctagccg tggccgacat gagtctggtt ccaggcagtc     1740

ttccagctat ggcccacatg ggtatggctc agggaggtct tcaagccgtg gcccatatga     1800

gtctggctcc ggtcactctt ctggcttagg tcaccaagag tctcgctcag gacagtcctc     1860

tggctacggt caacacggat ctagctcggg tcattcctct acccatgggc aacatggttc     1920

tacatcagga cagtcatcga gctgtggcca acatggagct acctcaggtc agtcttccag     1980

ccacggtcag catggctctg gctcaagtca gtcttctcgc tatggccaac agggctctgg     2040

atctggccag tctcctagtc gcggccgaca tgggtccgat tttgggcact cttccagcta     2100

cggccaacat gggtctggct ccggttggtc ttcaagcaat ggcccacatg ggtctgtctc     2160

aggccagtct tccggctttg gtcacaagtc tggctcaggg cagtcctctg gttacagtca     2220

gcatggatct ggctcaagtc actcctccgg ctacagaaaa cacggctcta ggtcaggaca     2280

gtcatctagg agtgaacaac acggatctag ctcaggtttg tcttccagct atggtcagca     2340

tgggtcgggc tcccatcaat cttcgggcca cggccgacaa gggtctggat ctggccactc     2400

tcctagccgt gtccgacatg ggtccagttc agggcactcc tccagccacg gccaacacgg     2460

gtctggcaca agttgttctt ccagctgtgg ccattatgag tctggctcag gccaggcttc     2520

tggttttggg caacacgagt ctggctcagg acagggctat agtcagcatg gttctgcctc     2580

aggtcacttc tctagccagg gacgacatgg atctacgtca gggcagtcat caagctccgg     2640

ccaacatgac tctagctcag gtcaatcttc cagctatggt cagcatgagt ctgcctccca     2700

tcacgcttcg ggccgcggcc gacatggctc tggatctggc cagtctccag gccacggcca     2760

gcgtgggtct gggtcagggc agtctcccag ctatggccga catgggtctg gctccggtcg     2820

gtcttccagc agtggccgac atgggtctgg ctcaggccag tcttctggct ttggtcacaa     2880

gtctagctca gggcagtcct ctggttacac tcagcatgga tctggctcag gtcactcctc     2940

cagctacgaa caacacggct ctaggtcagg acagtcatct aggagcgaac aacatggatc     3000

tagctcaggt tcgtcttcca gctatggtca gcatgggtct ggctcccgtc agtctttggg     3060

ccacggccaa catgggtctg gatctggcca gtctcctagc cctagccgtg gccgacatgg     3120

gtctggttcc gggcagtctt ccagctatgg cccatatagg tctggctcag ggtggtcttc     3180

aagccgtggc ccatatgagt ctggctccgg tcactcttct ggcttaggtc accgagagtc     3240

tcgctcagga cagtcctctg gctacggtca acatggatct agctcaggtc attcctctac     3300

ccatgggcaa cacggttcta catcaggaca gtcatcgagc tgtggccaac atggagctag     3360

ctcaggtcag tcttccagcc acggtcagca tggctctggc tcaagtcagt cttctggcta     3420

tggccgacag ggctctggat ctggccagtc tccaggccac ggccagcgtg ggtctgggtc     3480

aaggcagtct cccagctacg gccgacatgg gtctggctcc ggtcggtctt ccagcagtgg     3540

ccaacatggg tctggcttag gcgagtcttc tggctttggt caccacgagt ctagctcagg     3600

gcagtcctct agttacagtc agcatgggtc tggctcaggt cactcctctg gctacggaca     3660

acacggctct agatcaggac agtcatctag gggtgaacga cacggatcta gctcaggttc     3720

gtcttcccac tatggtcagc atgggtctgg ctcccgtcag tcttcgggcc acggccgaca     3780

agggtctgga tctggccatt cccctagccg cggccgacat gggtccggtt tggggcactc     3840

ctccagccac ggccaacatg ggtctggctc aggtcgttct tccagccgtg gcccatatga     3900

gtctcgctcg ggtcactctt ctgtctttgg tcaacatgag tctggctcag gacattcctc     3960

tgcttacagt cagcatggta gtggctcagg gcacttctgt agccaaggac agcatggttc     4020

tacatcagga cagtcatcaa cctttgacca ggagggatct agcacaggcc agtcttccag     4080

ctatggccac cgtggctctg gctccagtca gtcttctggc tatggccgac atggggctgg     4140

atctggccag tctcctagtc gcggccgaca tgggtccggt tctgggcact cttccagcta     4200

cggccaacat gggtctggct ccggttggtc ttccagcagt ggccgacatg ggtctggctc     4260

aggtcagtct tctggatttg gtcaccacga gtctagctca tggcagtcct ctggttgcac     4320

tcagcatgga tctggctcag gtcactcctc cagctacgaa caacacggct ctaggtcagg     4380

acagtcatct aggggtgaac gacacggatc tagctcaggt tcatcttcca gctatggtca     4440

gcatgggtct ggctcccgtc agtctttggg ccacggccaa catgggtctg gatctggcca     4500

gtctcctagc cctagccgtg gccgacatgg gtctggttct gggcagtctt ccagctacag     4560

cccatatggg tctggctcag ggtggtcttc cagccgtggc ccatatgagt ctggctccag     4620

tcactcttct ggcttaggtc accgagagtc tcgctcagga cagtcctctg gctacggtca     4680

acatggatct agctcaggtc attcctctac ccatgggcaa catggttcta catcaggaca     4740

gtcatcgagc tgtggccaac atggagctag ctcaggtcag tcttccagcc acggtcagca     4800

tggctctggc tcaagtcagt cttctggcta tggccgacag ggctctggat ctggccagtc     4860

tccaggccac ggccagcgtg ggtctgggtc aaggcagtct cccagctacg gccgacatgg     4920

gtctggctcc ggtcggtctt ccagcagtgg ccaacatggg tctggcttag gcgagtcttc     4980

tggctttggt caccacgagt ctagctcagg gcagtcctct agttacagtc agcatgggtc     5040

tggctcaggt cactcctctg gctacggaca acacggctct agatcaggac agtcatctag     5100

gggtgaacga cacggatcta gctcacgttc gtcttcccgc tatggtcagc atgggtctgg     5160

ctcccgtcag tcttcgggcc acggccgaca agggtctgga tctggccagt cccctagccg     5220

cggccgacat gggtccggtt tggggcactc ctccagccac ggccaacatg ggtctggctc     5280

aggtcgttct tccagccgtg gcccatatga gtctcgctcg ggtcactctt ctgtctttgg     5340

tcaacatgag tctggctcag gacattcctc tgcttacagt cagcatggta gtggctcagg     5400

gcacttctgt agccaaggac agcatggttc tacatcagga cagtcatcaa cctttgacca     5460

ggagggatct agcacaggtc agtcttccag ccacggtcag catggctctg gctcaagtca     5520

gtcttctagc tatggccaac agggctctgg atctggccag tctcctagtc gcggccgaca     5580

tgggtccggt tccgggcact cttccagcta cggccaacat gggtctggct ccggttggtc     5640

ttccagcagt ggccgacatg ggtctggctc aggtcagtct tctggatttg gtcaccatga     5700

gtctagctca tggcagtcct ctggttacac tcagcatgga tctggctcag gtcactcctc     5760

cagctacgaa caacacggct ctaggtcagg acagtcatct aggggtgaac aacacggatc     5820

tagctcaggt tcatcttcca gctatggtca gcatgggtct ggctcccgtc agtctttggg     5880

ccacggccaa catgggtctg gatctggcca gtctcctagc cctagccgtg gccgacatgg     5940

gtctggttct gggcagtctt ccagctacgg cccatatggg tctggctcag ggtggtcttc     6000

cagccgtggc ccatatgagt ctggctccgg tcactcttct ggcttaggtc accgagagtc     6060

tcgctcagga cagtcctctg gctacggtca acatggatct agctcaggtc attcctctac     6120

ccatgggcaa catggttctg catcaggaca gtcatcgagc tgtggccaac atggagctag     6180

ctcaggtcag tcttccagcc acggtcagca tggctctggc tcaagtcagt cttctggcta     6240

tggccgacag ggctctggat ctggccagtc tccaggccac ggccagcgtg ggtctgggtc     6300

aaggcagtct cccagctatg gccgacatgg gtctggctcc ggtcggtctt ccagcagtgg     6360

ccaacatggg cctggcttag gcgagtcttc tggctttggt caccacgagt ctagctcagg     6420

gcagtcctct agttacagtc agcatgggtc tggctcaggt cactcctctg gctacggaca     6480

acacggctct agatcaggac agtcatctag gggtgaacga cacggatcta gctcaggttc     6540

gtcttcccgc tatggtcagc atgggtctgg ctcccgtcag tcttcgggcc acggccgaca     6600

agggtctgga tctggccatt cccctagccg cggccgacat gggtccggtt cggggcactc     6660

ctccagccac ggccaacatg ggtctggctc aggtcgttct tccagccgtg gcccatatga     6720

gtctcgctcg ggtcactctt ctgtctttgg tcaacatgag tctggctcag gacattcctc     6780

tgcttacagt cagcatggta gtggctcagg gcacttctgt agccaaggac agcatggttc     6840

tacatcagga cagtcatcaa cctttgacca ggagggatct agcacaggtc agtcttccag     6900

ccacggtcag catggctctg gctcaagtca gtcttctagc tatggccaac agggctctgg     6960

atctggccag tctcctagtc gcggccgaca tgggtccggt tccgggcact cttccagcta     7020

cggccaacat gggtctggct ccggttggtc ttccagcagt ggccgacatg ggtctggctc     7080

aggtcagtct tctggatttg gtcaccacga gtctagctca tggcagtcct ctggttacac     7140

tcagcatgga tctggctcag gtcactcctc cagctacgaa caacacggct ctaggtcagg     7200

acagtcatct aggggtgaac gacacggatc tagctcaggt tcatcttcca gctatggtca     7260

gcatgggtct ggctcccgtc agtctttggg ccacggccaa catgggtctg gatctggcca     7320

gtctcctagc cctagccgtg gccgacatgg gtctggttct gggcagtctt ccagctacag     7380

cccatatggg tctggctcag ggtggtcttc cagccgtggc ccatatgagt ctggctccgg     7440

tcactcttct ggcttaggtc accgagagtc tcgctcagga cagtcctctg gctacggtca     7500

acatggatct agctcaggtc attcctctac ccatgggcaa catggttcta catcaggaca     7560

gtcatcgagc tgtggccaac atggagctag ctcaggtcag tcttccagcc acggtcagca     7620

tggctctggc tcaagtcagt cttctggcta tggccgacag ggctctggat ctggccagtc     7680

tccaggccac ggccagcgtg ggtctgggtc aaggcagtct cccagctacg gccgacatgg     7740

gtctggctcc ggtcggtctt ccagcagtgg ccaacatggg tctggcttag gcgagtcttc     7800

tggctttggt caccacgagt ctagctcagg gcagtcctct agttacagtc agcatgggtc     7860

tggctcaggt cactcctctg gctacggaca acacggctct agatcaggac agtcatctag     7920

gggtgaacga cacggatcta gctcaggttc gtcttcccac tatggtcagc atgggtctgg     7980

ctcccgtcag tcttcgggcc acggccgaca agggtctgga tctggccagt cccctagccg     8040

cggccgacat gggtccggtt tggggcactc ctccagccac ggccaacatg ggtctggctc     8100

aggtcgttct tccagccgtg gcccatatga gtctcgcttg ggtcactctt ctgtctttgg     8160

tcaacatgag tctggctcag gacattcctc tgcttacagt cagcatggta gtggctcagg     8220

gcacttctgt agccaaggac agcatggttc tacatcagga cagtcatcaa cctttgacca     8280

ggagggatct agcacaggcc agtcttccag ctatggccac cgtggctctg gctccagtca     8340

gtcttctggc tatggccgac atggggctgg atctggccag tctcttagcc acggccgaca     8400

cgggtctggt tcagggcagt cttccagcta cggccaacat gggtctggct caggacagtc     8460

ctctggttat agtcagcatg gaagtggctc agggcaagat gggtattctt attgcaaagg     8520

aggaagtaac catgatgggg gaagttctgg ctcatatttt ctcagttttc ctagtagcac     8580

ttcaccctat gaatatgtcc aagagcagag gtgctacttt tatcagtgaa taataaacat     8640

aaatgcaatt tactcaagta gcaatttaag aaataggaaa gtcatctatg aattcatcat     8700

gaaagacaag caatccatca tgaaattcgt tctaaaagtg aatcaatgca tttctgtctc     8760

tttctttaga gcctaaaact gtagcatata tcttgttatg gggttccttc caaagactgt     8820

taggcatttg tgctactttg ttagaaaata ctgagtggaa taacttgtta gaatgagggt     8880

taaactttga ggaataatga aaagctttta aagagctttg ggtttagttg gagttgtctt     8940

tttgagagct catcattcat ttatagatgg tgccaaagct aaccttacat ttcttagaag     9000

caaaatatta caaatgcatt accagtccta gatacaaagc tttgttttac agcaattagt     9060

gtaccctaat ttttagtgtg ccccaagttt ggtgtgtccc aatttttggt attgtggcag     9120

aaggtgaagg ctctgaaagc aaagatgcag cagcggtagt gtctttactt atcaaaacca     9180

tcaagtcctt tttcttgggt atatatttaa tcagtaagtt aattagtggc ataaaaaagt     9240

agcatcaggg tcttttccca agccagtgag caagagcatt atttcataaa gaatagggat     9300

ttatcatttc aggaaaaaaa aaaacattca aatgtgggct ttagcttgtt ttcagcagaa     9360

agatcttgct ccctatttct aagaggctgc tcaatattgg gaaatatatt gaggagttat     9420

tccatggaaa tacaatgctt tccacctact actgtagttc aataacgttt ccacctgaaa     9480

aaatatcatc catgcccaga tgaaaaggaa gagtatctgt cactgctaca tagttcctta     9540

atttgactgt aacacatttg tttcaagtct ttggattcaa acaaccggat tgtattaaaa     9600

ttgacaataa ataaatgttg att                                             9623


<210> 1673
<211> 1462
<212> DNA
<213> Homo sapiens

<400> 1673
atggcggccc caacggccgt ccaggacgtg gagcgaaatg agctcgggcg ctgacggcgg       60

cggtggcgct gcggtggcgg cgcggtcgga caagggcagt cccggggagg acggtttcgt      120

cccgtcggcg ctggggaccc gcgagcattg ggatgctgtc tatgagagag aactgcaaac      180

tttccgagaa tatggagata caggtgaaat ctggtttgga gaagagagta tgaatcgact      240

aataaggtgg atgcagaaac acaagattcc actggatgct tcagtgcttg atattggaac      300

tggaaatggt gttttcctgg ttgaacttgc aaaatttggt ttctctaata ttactggaat      360

tgattactct ccttctgcaa ttcagctttc tggaagtatt atagaaaaag aaggtttatc      420

taacattaag ttaaaggtag aagacttttt gaatctctcc acacagctgt ctggatttca      480

tatttgtatt gacaaaggga cttttgatgc cataagcctt aatcctgaca atgcaattga      540

gaagaggaag caatatgtga aatctctctc cagggtgttg aaagtaaaag gcttttttct      600

aataacgtca tgtaattgga ccaaggaaga gttgctaaat gaattcagtg aaggttggag      660

tacagtggca ggattttggc tcactgcagc cttgacttcc tgggctcaag cgatcttttc      720

cacttcagcc tcccgagtag gtggaactac aggcacacat catcatgcct ggataatttt      780

tgtattttta gcagagacga ggttttgcca tgttgtccag gctggtctgg aactcctggg      840

ctcaagtgat tctcccacct ggcctcccaa agtgctggga ttataccatg ccaggccctc      900

gttggcattt tagatttgaa cttctcgaag agctaccaac acccaagttc agctttggag      960

gcagatctgg aaacagtgta gcagcattgg ttttccaaaa aatgtgagac tttttcttgg     1020

acgaattcag gtagctacac agaatctaca cagcaaagtt aacctgacac agaaaatcct     1080

tgtgcaaata aatgcttagt aagtacacag gatgcacatg ttgaatagag tatactggat     1140

tggtgaaaga aaataataat aatgagcatc taagtggttg ggttttagag atcaatcaag     1200

aataatttta attttctttt gtatttgaaa tgtaaatagt tttcttttcg attaaaaaaa     1260

tttcctataa ctgctaaaca gttaaaaact ttaaagtagt aaatgagttt atagaaagca     1320

tgtattcttg atttttgtgc cttggtaaag ttgataacta tttatgaata tttgaccaaa     1380

ttattccagc atcagaataa taagcaaaat aactttgtta gtgttttgtt agactgttta     1440

tgaaatataa caagaaatac ta                                              1462


<210> 1674
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 1674
gaggagcagg gccgggcgcc atggcaccgt ggggcaagcg gctggctggc gtgcgcgggg       60

tgctgcttga catctcgggc gtgctgtacg acagcggcgc gggcggcggc acggccatcg      120

ccggctcggt ggaggcggtg gccagactga agcgttcccg gctgaaggtg aggttctgca      180

ccaacgagtc gcagaagtcc cgggcagagc tggtggggca gcttcagagg ctgggatttg      240

acatctctga gcaggaggtg accgccccgg caccagctgc ctgccagatc ctgaaggagc      300

aaggcctgcg accatacctg ctcatccatg acggagtccg ctcagaattt gatcagatcg      360

acacatccaa cccaaactgt gtggtaattg cagacgcagg agaaagcttt tcttatcaaa      420

acatgaataa cgccttccag gtgctcatgg agctggaaaa acctgtgctc atatcactgg      480

gaaaagggcg ttactacaag gagacctctg gcctgatgct ggacgttggt ccctacatga      540

aggcgcttga gtatgcctgt ggcatcaaag ccgaggtggt ggggaagcct tctcctgagt      600

ttttcaagtc tgccctgcaa gcgataggag tggaagccca ccaggcccag tgacgagcac      660

catccggaag tgaaggctga tgggtacgtg gacaacctcg cagaggcagt ggacctgctg      720

ctgcagcacg ccgacaagtg atggcctcct gggagagccc cgcctcctcc acccctgcct      780

ctcctccacc cctgcctccc ctccacccct gcctctcctc cacccgccca ggagagcccc      840

acctcctcca cccctgcctc tcctccaccc ctgcctcccc tccacctgcc ccagtgccca      900

gaccaaccaa ggccctgaca gccctgcctt ctgccctctg ccctgcatgg gcaggcattt      960

gttccctacc tgggtggcct gctcccctgc ctgggccctg acttcagctc cctgtagtga     1020

agtccaggag ggtgggacag gcctgtcagg cctctgggaa tctcccaaat cccagaactc     1080

accactcacc atgggccttt aaatgcagta aactccacct aaccagattc aggggcacta     1140

tgcccactgc ctcctcttca gactctttgc atttcagtga agagcctgga agaaacccag     1200

gggcctccta tgcacagatc ttgcagccca gaaccaagtc agcctccctg cgactgccca     1260

ggcacactgc ccaccacccc acccccgaaa caatgccagc ccgctgcttt ttctatcctc     1320

ccagtcacct ttgcagacaa agaccagggg cagctcccga gggcactgtg aaggctccca     1380

tgccacacag tgagaactgt agcctctgcg tccaaggcac acagggtact ttctggaccc     1440

actgctggac agacttgaag gtgtcatgcc cggtgtgtgc aggaggaaac taacagttca     1500

gtaaactctg ccttgaccag ca                                              1522


<210> 1675
<211> 1622
<212> DNA
<213> Homo sapiens

<400> 1675
gcggagctga ggagcagggc cgggcgccat ggcaccgtgg ggcaagcggc tggctggcgt       60

gcgcggggtg ctgcttgaca tctcgggcgt gctgtacgac agcggcgcgg gcggcggcac      120

ggccatcgcc ggctcggtgg aggcggtggc cagactgaag cgttcccggc tgaaggtgag      180

gttctgcacc aacgagtcgc agaagtcccg ggcagagctg gtggggcagc ttcagaggct      240

gggatttgac atctctgagc aggaggtgac cgccccggca ccagctgcct gccagatcct      300

gaaggagcaa ggcctgcgac catacctgct catccatgac ggagtccgct cagaatttga      360

tcagatcgac acatccaacc caaactgtgt ggtaattgca gacgcaggag aaagcttttc      420

ttatcaaaac atgaataacg ccttccaggt gctcatggag ctggaaaaac ctgtgctcat      480

atcactggga aaagggcgtt actacaagga gacctctggc ctgatgctgg acgttggtcc      540

ctacatgaag gcgcttgagt atgcctgtgg catcaaagcc gaggtggtgg ggaagccttc      600

tcctgagttt ttcaagtctg ccctgcaagc gataggagtg gaagcccacc aggccgtcat      660

gattggggac gatatcgtgg gcgacgtcgg cggtgcccag cggtgtggaa tgagagcgct      720

gcaggtgcgc accgggaagt tcaggcccag tgacgagcac catccggaag tgaaggctga      780

tgggtacgtg gacaacctcg cagaggcagt ggacctgctg ctgcagcacg ccgacaagtg      840

atggcctcct gggagagccc cgcctcctcc acccctgcct ctcctccacc cctgcctccc      900

ctccacccct gcctctcctc cacccgccca ggagagcccc acctcctcca cccctgcctc      960

tcctccaccc ctgcctcccc tccacctgcc ccagtgccca gaccaaccaa ggccctgaca     1020

gccctgcctt ctgccctctg ccctgcatgg gcaggcattt gttccctacc tgggtggcct     1080

gctcccctgc ctgggccctg acttcagctc cctgtagtga agtccaggag ggtgggacag     1140

gcctgtcagg cctctgggaa tctcccaaat cccagaactc accactcacc atgggccttt     1200

aaatgcagta aactccacct aaccagattc aggggcacta tgcccactgc ctcctcttca     1260

gactctttgc atttcagtga agagcctgga agaaacccag gggcctccta tgcacagatc     1320

ttgcagccca gaaccaagtc agcctccctg cgactgccca ggcacactgc ccaccacccc     1380

acccccgaaa caatgccagc ccgctgcttt ttctatcctc ccagtcacct ttgcagacaa     1440

agaccagggg cagctcccga gggcactgtg aaggctccca tgccacacag tgagaactgt     1500

agcctctgcg tccaaggcac acagggtact ttctggaccc actgctggac agacttgaag     1560

gtgtcatgcc cggtgtgtgc aggaggaaac taacagttca gtaaactctg ccttgaccag     1620

ca                                                                    1622


<210> 1676
<211> 6054
<212> DNA
<213> Homo sapiens

<400> 1676
agactaccgg cggcgacgac cacaggagca tggcggacac cgacctgttc atggaatgtg       60

aggaggagga gttggagcca tggcagaaaa tcagtgatgt cattgaggac tctgtagttg      120

aagattataa ttcagtggat aaaactacca cagtttctgt gagccagcag ccagtctcgg      180

ctccagtgcc catcgctgcc catgcttctg ttgctgggca cctctctaca tccaccaccg      240

ttagtagcag cggggcacag aacagcgaca gtacaaagaa gactcttgtc acactaattg      300

ccaacaacaa tgccccaggt acccagtttg ttaagccgac agttggagtt ccacaagtgt      360

tctcccagat gacccctgtg aggccaggct ccacaatgcc tgtgaggccc accaccaaca      420

ccttcaccac cgtcatcccg gccactctta ccattcgaag caccgtccca cagtcccagt      480

cccagcagac caagtccact cccagcactt ctaccactcc cactgccaca cagccaacct      540

cactggggca actagctgtt cagtctccag gccagtcaaa ccagaccacg aatcccaagc      600

tagctccctc cttcccctct ccacctgcag tgagcattgc cagctttgtc actgtgaagc      660

gacctggtgt tacaggcgaa aatagcaatg aagtggccaa attggtgaat acccttaaca      720

ccatcccttc cctgggccag agtcctgggc cagtggtggt gtccaacaac agctctgctc      780

atggctctca aagaaccagc ggacctgagt cttcaatgaa agtgacctct tccatcccag      840

tatttgacct ccaggatggt ggacggaaaa tatgtccacg atgtaatgct caatttcgtg      900

ttactgaagc tttgagaggt cacatgtgtt actgttgccc agaaatggtt gaataccaga      960

agaaaggaaa gtccctggat tcagaaccca gtgtcccatc agcagcaaag cccccatccc     1020

ctgagaaaac agctcctgtt gcttccacac cctcttctac acctattcct gctctgtcac     1080

cgcctaccaa agtaccagaa ccaaatgaga acgtgggcga tgccgtccag accaaactca     1140

ttatgcttgt agatgacttc tactatggac gggatggtgg caaagtagcc cagctcacaa     1200

atttccctaa ggtcgccaca tctttccgat gcccacattg taccaaaagg ctaaaaaaca     1260

atattcgatt catgaaccat atgaaacacc acgtagaact cgatcagcag aacggtgagg     1320

tagatggtca cactatctgc cagcactgtt accgccagtt ttccactccc ttccagcttc     1380

agtgccactt ggaaaatgtt catagtccct atgaatctac taccaagtgc aagatctgtg     1440

aatgggcgtt tgaaagtgag ccactatttc tccagcatat gaaggatact cataagcctg     1500

gagagatgcc ttatgtttgc caggtgtgtc aatatcgctc ctcactctac tctgaggtag     1560

atgtccattt tcggatgatc catgaggata cccggcatct gctctgccct tattgcctga     1620

aggtcttcaa aaatggcaat gcattccaac agcattacat gaggcaccag aagagaaatg     1680

tttatcactg caacaaatgc cggctgcagt ttctctttgc caaggacaaa attgaacaca     1740

agcttcaaca ccataaaacc ttccgtaaac ccaagcagct ggagggcttg aaaccaggca     1800

ccaaggtgac aatccgggct tcccgagggc agccacgaac tgttcctgta tcctctaatg     1860

atacacctcc cagcgccttg caggaggcag caccgctgac ctcctcaatg gaccctctgc     1920

ctgtcttcct ttatccccct gtccagcgca gcatccagaa gagagctgtt aggaaaatga     1980

gtgtcatggg ccggcagaca tgcctggagt gcagcttcga gatcccagac ttccctaatc     2040

atttccctac ttacgtacac tgctctctgt gtcgctatag cacctgctgt tctcgagctt     2100

atgccaacca catgatcaac aatcatgttc cacggaagag ccccaagtat ttggctttgt     2160

ttaaaaattc tgtgagtgga atcaagctgg cctgcacttc atgtaccttt gttacctctg     2220

tgggcgatgc tatggccaag catttggtat tcaacccctc tcacagatcc agcagcatcc     2280

tgccacgggg actcacttgg atagctcact caaggcatgg ccagactcgt gaccgagtgc     2340

atgaccggaa cgtgaagaat atgtaccctc ctccttcctt ccccactaac aaagctgcca     2400

ctgtgaaatc tgcgggggcc accccagctg agcctgaaga gctactaact cccttagccc     2460

cagcactccc atcaccagcc tcaactgcaa ccccaccacc aacccccact cacccgcagg     2520

ctttagccct tccaccgctg gctacagagg gagccgaatg tctgaatgtt gatgatcagg     2580

atgaagggag cccagtcacc caagaacctg agctagcatc aggtggtggt ggtagtggtg     2640

gagttggcaa aaaggagcag ctgtctgtga agaagcttcg agtagtactg tttgctctat     2700

gctgcaatac agaacaggca gctgaacact tccgaaatcc ccagcgacgt attcgccgtt     2760

ggcttcgacg tttccaggcc tcccaggggg agaatctaga gggcaaatat ctgagctttg     2820

aggcagaaga gaaactggct gagtgggtgc taacccagcg cgaacaacag ctacctgtaa     2880

atgaggagac cttgttccag aaggccacca aaataggacg ttctttggaa ggggggttta     2940

agatctccta tgagtgggct gtgcgtttca tgctgcggca ccacctgact ccccatgccc     3000

ggcgagctgt ggcccacacc ctacctaagg atgtagcaga gaatgcagga ctcttcattg     3060

attttgtaca acggcagatt cacaaccagg acttaccctt gtctatgatt gtggctattg     3120

atgagatctc tttgttcctg gatacagagg tgctgagcag tgatgatcga aaggagaatg     3180

ccctgcagac agtgggcaca ggggaacctt ggtgtgatgt agtcctagcc attctggcag     3240

atggcactgt ccttcccacc ctggttttct acagagggca gatggatcag cctgctaaca     3300

tgccagactc catattgcta gaggcaaagg agagtggcta cagtgatgac gagatcatgg     3360

agctgtggtc aactcgagtg tggcagaagc acacagcttg ccagcgcagc aaaggcatgc     3420

ttgtgatgga ctgtcatcgc actcacttgt cagaagaggt actggctatg cttagtgcct     3480

ctagcacttt gcctgcagtg gtcccagcag gctgtagctc caaaattcag ccattagatg     3540

tatgcatcaa aagaactgtc aagaacttcc tgcataaaaa atggaaggaa caggctcggg     3600

aaatggcaga tactgcatgt gattctgatg tcctgcttca gctggtgctt gtctggctgg     3660

gtgaagtgct aggtgtcatt ggggactgtc cagagctagt tcagcgctcc ttcctggtgg     3720

ctagtgttct gcctggcccc gatggcaaca ttaactcacc tacaagaaat gctgacatgc     3780

aggaggagct aattgcctcc ctagaggagc aactgaagct gagtggggaa cattctgagt     3840

cttccactcc acgacccaga tcatctcctg aagagacaat tgagcctgaa agtcttcacc     3900

agctctttga gggtgaaagt gagaccgagt ctttctatgg ctttgaagaa gctgacctag     3960

atctgatgga gatttgagtg ttggggtcat gagggggtgt ggagtgaggg tgggaacatg     4020

tgagggaggg taaaggggct tagggaaaag ggggcatacc aggtggggta tttggtttct     4080

attttttaat tttataccac cactcccccc tgaagttgac ttacacttcc ctgtggattt     4140

gtggattaat taggaaaacc aatagtaatc acgtctgagc caaggagctg gcccattggt     4200

cattcacttc tgctaaaaac aggtttttgt gacttttttt ttttttaaat ttaaatcact     4260

gtgtttggta tttttctgac aaaattaaga aaaagaaaaa aaattatttg tgggcaaatg     4320

ttaaattttt ttgtttcccc ttttacctca attgtatcat agtactgggt ttttttgttt     4380

gttttattgt gtggccaatg tctttgggca tgatgctatc taatcattgt taatgtgaga     4440

acatttctga agatgggaaa gacaaattat gtagctcaca aactggttta ttatatatat     4500

ggataaaaaa cttttttcat tgtggtctta acacttttat ataaaaatga aaatggaaaa     4560

aaagtcccac tgaactctct cttccttctc cttttctttc cttccctctc cagagatgtt     4620

ggtttctaca gcaaccctag atataaaatt gtggctttaa aaatgcatga aaccaccttt     4680

aattatccag aatgaataga tttgtctttt cctcaccacc ttccctccaa aacatgacat     4740

aaacaatatt ttttgcactt gtgatccttg gcccctttcc ccattctcaa caccatccat     4800

ccctctggac aaaggatcat acaggtgtta ttagcaagca agagatactg aagcgatcaa     4860

acagttttag ggtggaagcc attcccagtt tgagtcttca tcctgtaagc ccccaggggc     4920

agtccctgct ttactgaact tcatcctgtt agatggagag catgcctgtt taagggatta     4980

ctggtcctac agccaggagc taattgttca agaagtgttg aactttaaaa agacaagacc     5040

acttgttgaa atccagcgtg ctctgtggct ttcccctatt tctcttaata cttagggaag     5100

aatctgacag gaagaagcgc acaggggtgt gcacaaagaa aatgacatga atctttattt     5160

ttcactgcca gcttcaagga aagaaaattt tttctacaat ttgcatgagg gattttttta     5220

attgtatgta ctcatggttg taaaccaaaa cgtactgtac cgtacagaga aaaggagcaa     5280

aaaaccaagt cttctgttta tcctgaggct ttccacaatg ttcccctcct gtgagccaag     5340

gaggcaaact gcacaagctt gtaaatggtt cgtctttaaa atgtacataa gtggaacatt     5400

taataaaatg aggggaaatg gatttataaa cttgtttttt ttctaggtga ccctgtttaa     5460

taggctttca cagactgggg aatgctcaag atgtgatggg cctggtggta caggtgtgac     5520

atttgttacc acccatttct cccaccccac cctgcttttt tgtttgtttg ttttttcatc     5580

ccccagcaca ctataatata gtgaactgga aaagtccctt ccagaaacag cttggccagc     5640

tttgtgaacc tttgacatct gaaaacaacc aaggatccat ctgggcttct cttccccagc     5700

tttttgcctg atgccatttt attgacagac aatggacttt gaagtcagcc tttgcctttg     5760

agaaagttca agaactatgg ttggtcacgt ctatctacaa cctaatccta ctctttggta     5820

gtctctgcag cagccacagc cttagcagag ctggggttcc tgtcttctgc acacgattga     5880

ctttcttgat gggtaatttt ttttaagatt ataccaacag tggatcagct gggttttggc     5940

caggaagttg tctttgtgga ctctgcctgc atggcttagt agtagaagga aatttttttt     6000

tggttttgtt ttttataatt cagtttaatc aataaacatg tatttattga ctgt           6054


<210> 1677
<211> 3331
<212> DNA
<213> Homo sapiens

<400> 1677
cgcagccggg gcctggtgca gcctccgcgg ccgctgtcag ggaagcgcag gcggccaatg       60

gaacccggga gcggtcgctg ctgctgaggc ggcagtgtcg gcagtccaac cgcgactgcc      120

cgcaccccct ccgcgggggt cccccagagg atcaactaaa ccttgaacta agaagaaaaa      180

tgtgttgtga gcagggggag cctcagctgc ctcaggccgt tcaggacaga agggtgtttc      240

tgaaggccgg agcaagtttt gaagaagtcc ctatcagatt acacttggtt gactactccg      300

gagcagccac taagagggat gaacaggcct gcgtggaaat tgaatgagat tagttgagtc      360

cacgctccat gagaatgctg aacaccatcc aaagcagcaa attgagattc cttgatttgg      420

ggaagaggtt tgggaggaac ccttcaataa ttggcatggg acaagagggg acccagtcca      480

agtgtatttg ggactcgcag tagggaggaa caattcagag agagcttgga agctcgaagt      540

ctggctgtgg ccatgggaga tacagtagtg gagcctgccc ccttgaagcc aacttctgag      600

cccacttctg gcccaccagg gaataatggg gggtccctgc taagtgtcat cacggagggg      660

gtcggggaac tatcagtgat tgaccctgag gtggcccaga aggcctgcca ggaggtgttg      720

gagaaagtca agcttttgca tggaggcgtg gcagtctcta gcagaggcac cccactggag      780

ttggtcaatg gggatggtgt ggacagtgag atccgttgcc tagatgatcc acctgcccag      840

atcagggagg aggaagatga gatgggggcc gctgtggcct caggcacagc caaaggagca      900

agaagacggc ggcagaacaa ctcagctaaa cagtcttggc tgctgaggct gtttgagtca      960

aaactgtttg acatctccat ggccatttca tacctgtata actccaagga gcctggagta     1020

caagcctaca ttggcaaccg gctcttctgc tttcgcaacg aggacgtgga cttctatctg     1080

ccccagttgc ttaacatgta catccacatg gatgaggatg tgggtgatgc cattaagccc     1140

tacatagtcc accgttgccg ccagagcatt aacttttccc tccagtgtgc cctgttgctt     1200

ggggcctatt cttcagacat gcacatttcc actcaacgac actcccgtgg gaccaagcta     1260

cggaagctga tcctctcaga tgagctaaag ccagctcaca ggaagaggga gctgccctcc     1320

ttgagcccgg cccctgacac agggctgtct ccctccaaaa ggactcacca gcgctctaag     1380

tcagatgcca ctgccagcat aagtctcagc agcaacctga aacgaacagc cagcaaccct     1440

aaagtggaga atgaggatga gcctgttcga ctggctcctg agagagaatt catcaagtcc     1500

ctgatggcga tcggcaagcg gctggccacg ctccccacca aagagcagaa aacacagagg     1560

ctgatctcag agctctccct gctcaaccat aagctccctg cccgagtctg gctgcccact     1620

gctggctttg accaccacgt ggtccgtgta ccccacacac aggctgttgt cctcaactcc     1680

aaggacaagg ctccctacct gatttatgtg gaagtccttg aatgtgaaaa ctttgacacc     1740

accagtgtcc ctgcccggat ccccgagaac cgaattcgga gtacgaggtc cgtagaaaac     1800

ttgcccgaat gtggtattac ccatgagcag cgagctggca gcttcagcac tgtgcccaac     1860

tatgacaacg atgatgaggc ctggtcggtg gatgacatag gcgagctgca agtggagctc     1920

cccgaagtgc ataccaacag ctgtgacaac atctcccagt tctctgtgga cagcatcacc     1980

agccaggaga gcaaggagcc tgtgttcatt gcagcagggg acatccgccg gcgcctttcg     2040

gaacagctgg ctcatacccc gacagccttc aaacgagacc cagaagatcc ttctgcagtt     2100

gctctcaaag agccctggca ggagaaagta cggcggatca gagagggctc cccctacggc     2160

catctcccca attggcggct cctgtcagtc attgtcaagt gtggggatga ccttcggcaa     2220

gagcttctgg cctttcaggt gttgaagcaa ctgcagtcca tttgggaaca ggagcgagtg     2280

cccctttgga tcaagccata caagattctt gtgatttcgg ctgatagtgg catgattgaa     2340

ccagtggtca atgctgtgtc catccatcag gtgaagaaac agtcacagct ctccttgctc     2400

gattacttcc tacaggagca cggcagttac accactgagg cattcctcag tgcacagcgc     2460

aattttgtgc aaagttgtgc tgggtactgc ttggtctgct acctgctgca agtcaaggac     2520

agacacaatg ggaatatcct tttggacgca gaaggccaca tcatccacat cgactttggc     2580

ttcatcctct ccagctcacc ccgaaatctg ggctttgaga cgtcagcctt taagctgacc     2640

acagagtttg tggatgtgat gggcggcctg gatggcgaca tgttcaacta ctataagatg     2700

ctgatgctgc aagggctgat tgccgctcgg aaacacatgg acaaggtggt gcagatcgtg     2760

gagatcatgc agcaaggttc tcagcttcct tgcttccatg gctccagcac cattcgaaac     2820

ctcaaagaga ggttccacat gagcatgact gaggagcagc tgcagctgct ggtggagcag     2880

atggtggatg gcagtatgcg gtctatcacc accaaactct atgacggctt ccagtacctc     2940

accaacggca tcatgtgaca cgctcctcag cccaggagtg gtggggggtc cagggcaccc     3000

tccctagagg gcccttgtct gagaaacccc aaaccaggaa accccaccta cccaaccatc     3060

cacccaaggg aaatggaagg caagaaacac gaaggatcat gtggtaactg cgagagcttg     3120

ctgaggggtg ggagagccag ctgtggggtc cagacttgtt ggggcttccc tgcccctcct     3180

ggtctgtgtc agtattacca ccagactgac tccaggactc actgccctcc agaaaacaga     3240

ggtgacaaat gtgagggaca ctggggcctt tcttctcctt gtaggggtct ctcagaggtt     3300

ctttccacag gccatcctct tattccgttc t                                    3331


<210> 1678
<211> 3340
<212> DNA
<213> Homo sapiens

<400> 1678
gggcctggtg cagcctccgc ggccgctgtc agggaagcgc aggcggccaa tggaacccgg       60

gagcggtcgc tgctgctgag gcggcagtgt cggcagtcca accgcgactg cccgcacccc      120

ctccgcgggg gtcccccaga gcttggaagc tcgaagtctg gctgtggcca tgggagatac      180

agtagtggag cctgccccct tgaagccaac ttctgagccc acttctggcc caccagggaa      240

taatgggggg tccctgctaa gtgtcatcac ggagggggtc ggggaactat cagtgattga      300

ccctgaggtg gcccagaagg cctgccagga ggtgttggag aaagtcaagc ttttgcatgg      360

aggcgtggca gtctctagca gaggcacccc actggagttg gtcaatgggg atggtgtgga      420

cagtgagatc cgttgcctag atgatccacc tgcccagatc agggaggagg aagatgagat      480

gggggccgct gtggcctcag gcacagccaa aggagcaaga agacggcggc agaacaactc      540

agctaaacag tcttggctgc tgaggctgtt tgagtcaaaa ctgtttgaca tctccatggc      600

catttcatac ctgtataact ccaaggagcc tggagtacaa gcctacattg gcaaccggct      660

cttctgcttt cgcaacgagg acgtggactt ctatctgccc cagttgctta acatgtacat      720

ccacatggat gaggatgtgg gtgatgccat taagccctac atagtccacc gttgccgcca      780

gagcattaac ttttccctcc agtgtgccct gttgcttggg gcctattctt cagacatgca      840

catttccact caacgacact cccgtgggac caagctacgg aagctgatcc tctcagatga      900

gctaaagcca gctcacagga agagggagct gccctccttg agcccggccc ctgacacagg      960

gctgtctccc tccaaaagga ctcaccagcg ctctaagtca gatgccactg ccagcataag     1020

tctcagcagc aacctgaaac gaacagccag caaccctaaa gtggagaatg aggatgagga     1080

gctctcctcc agcaccgaga gtattgataa ttcattcagt tcccctgttc gactggctcc     1140

tgagagagaa ttcatcaagt ccctgatggc gatcggcaag cggctggcca cgctccccac     1200

caaagagcag aaaacacaga ggctgatctc agagctctcc ctgctcaacc ataagctccc     1260

tgcccgagtc tggctgccca ctgctggctt tgaccaccac gtggtccgtg taccccacac     1320

acaggctgtt gtcctcaact ccaaggacaa ggctccctac ctgatttatg tggaagtcct     1380

tgaatgtgaa aactttgaca ccaccagtgt ccctgcccgg atccccgaga accgaattcg     1440

gagtacgagg tccgtagaaa acttgcccga atgtggtatt acccatgagc agcgagctgg     1500

cagcttcagc actgtgccca actatgacaa cgatgatgag gcctggtcgg tggatgacat     1560

aggcgagctg caagtggagc tccccgaagt gcataccaac agctgtgaca acatctccca     1620

gttctctgtg gacagcatca ccagccagga gagcaaggag cctgtgttca ttgcagcagg     1680

ggacatccgc cggcgccttt cggaacagct ggctcatacc ccgacagcct tcaaacgaga     1740

cccagaagat ccttctgcag ttgctctcaa agagccctgg caggagaaag tacggcggat     1800

cagagagggc tccccctacg gccatctccc caattggcgg ctcctgtcag tcattgtcaa     1860

gtgtggggat gaccttcggc aagagcttct ggcctttcag gtgttgaagc aactgcagtc     1920

catttgggaa caggagcgag tgcccctttg gatcaagcca tacaagattc ttgtgatttc     1980

ggctgatagt ggcatgattg aaccagtggt caatgctgtg tccatccatc aggtgaagaa     2040

acagtcacag ctctccttgc tcgattactt cctacaggag cacggcagtt acaccactga     2100

ggcattcctc agtgcacagc gcaattttgt gcaaagttgt gctgggtact gcttggtctg     2160

ctacctgctg caagtcaagg acagacacaa tgggaatatc cttttggacg cagaaggcca     2220

catcatccac atcgactttg gcttcatcct ctccagctca ccccgaaatc tgggctttga     2280

gacgtcagcc tttaagctga ccacagagtt tgtggatgtg atgggcggcc tggatggcga     2340

catgttcaac tactataaga tgctgatgct gcaagggctg attgccgctc ggaaacacat     2400

ggacaaggtg gtgcagatcg tggagatcat gcagcaaggt tctcagcttc cttgcttcca     2460

tggctccagc accattcgaa acctcaaaga gaggttccac atgagcatga ctgaggagca     2520

gctgcagctg ctggtggagc agatggtgga tggcagtatg cggtctatca ccaccaaact     2580

ctatgacggc ttccagtacc tcaccaacgg catcatgtga cacgctcctc agcccaggag     2640

tggtgggggg tccagggcac cctccctaga gggcccttgt ctgagaaacc ccaaaccagg     2700

aaaccccacc tacccaacca tccacccaag ggaaatggaa ggcaagaaac acgaaggatc     2760

atgtggtaac tgcgagagct tgctgagggg tgggagagcc agctgtgggg tccagacttg     2820

ttggggcttc cctgcccctc ctggtctgtg tcagtattac caccagactg actccaggac     2880

tcactgccct ccagaaaaca gaggtgacaa atgtgaggga cactggggcc tttcttctcc     2940

ttgtaggggt ctctcagagg ttctttccac aggccatcct cttattccgt tctggggccc     3000

aggaagtggg gaagagtagg ttctcggtac ttaggacttg atcctgtggt tggccactgg     3060

ccatgctgct gcccagctct acccctccca gggacctacc cctcccaggg accgacccct     3120

ggcccaagct ccccttgctg gcgggcgctg cgtgggccct gcacttgctg aggttcccca     3180

tcatgggcaa ggaagggaat tcccacagcc ctccagtgta ctgagggtac tggcctagcc     3240

atgtggaatt ccctaccctg actccttccc caaacccagg gaaaagagct ctcaattttt     3300

tatttttaat ttttgtttga aataaagtcc ttagttagcc                           3340


<210> 1679
<211> 3934
<212> DNA
<213> Homo sapiens

<400> 1679
ccccgccccc ttttctattt ctgaacaggc atgttccagg cagctcaccc gactccttag       60

attactatgg aatcggtagg gtcctgaccg ctggggaagc aggaaagcgt atcctgggaa      120

gaaaggcttg gcttggactc cggagaagaa tactacatcg agacctgctg gggaatttta      180

ttttatttta ttattttttt ggtcttggtt gtactgaggg aggaagaaga ggttgtgtgg      240

cccggtcgaa cttgtggcag cctgaaggcc ccctcaggcg gcgccgcggg cagccccgca      300

gccggggcct ggtgcagcct ccgcggccgc tgtcagggaa gcgcaggcgg ccaatggaac      360

ccgggagcgg tcgctgctgc tgaggcggca gtgtcggcag tccaaccgcg actgcccgca      420

ccccctccgc gggggtcccc cagagcttgg aagctcgaag tctggctgtg gccatgggag      480

atacagtagt ggagcctgcc cccttgaagc caacttctga gcccacttct ggcccaccag      540

ggaataatgg ggggtccctg ctaagtgtca tcacggaggg ggtcggggaa ctatcagtga      600

ttgaccctga ggtggcccag aaggcctgcc aggaggtgtt ggagaaagtc aagcttttgc      660

atggaggcgt ggcagtctct agcagaggca ccccactgga gttggtcaat ggggatggtg      720

tggacagtga gatccgttgc ctagatgatc cacctgccca gatcagggag gaggaagatg      780

agatgggggc cgctgtggcc tcaggcacag ccaaaggagc aagaagacgg cggcagaaca      840

actcagctaa acagtcttgg ctgctgaggc tgtttgagtc aaaactgttt gacatctcca      900

tggccatttc atacctgtat aactccaagg agcctggagt acaagcctac attggcaacc      960

ggctcttctg ctttcgcaac gaggacgtgg acttctatct gccccagttg cttaacatgt     1020

acatccacat ggatgaggat gtgggtgatg ccattaagcc ctacatagtc caccgttgcc     1080

gccagagcat taacttttcc ctccagtgtg ccctgttgct tggggcctat tcttcagaca     1140

tgcacatttc cactcaacga cactcccgtg ggaccaagct acggaagctg atcctctcag     1200

atgagctaaa gccagctcac aggaagaggg agctgccctc cttgagcccg gcccctgaca     1260

cagggctgtc tccctccaaa aggactcacc agcgctctaa gtcagatgcc actgccagca     1320

taagtctcag cagcaacctg aaacgaacag ccagcaaccc taaagtggag aatgaggatg     1380

agcctgttcg actggctcct gagagagaat tcatcaagtc cctgatggcg atcggcaagc     1440

ggctggccac gctccccacc aaagagcaga aaacacagag gctgatctca gagctctccc     1500

tgctcaacca taagctccct gcccgagtct ggctgcccac tgctggcttt gaccaccacg     1560

tggtccgtgt accccacaca caggctgttg tcctcaactc caaggacaag gctccctacc     1620

tgatttatgt ggaagtcctt gaatgtgaaa actttgacac caccagtgtc cctgcccgga     1680

tccccgagaa ccgaattcgg agtacgaggt ccgtagaaaa cttgcccgaa tgtggtatta     1740

cccatgagca gcgagctggc agcttcagca ctgtgcccaa ctatgacaac gatgatgagg     1800

cctggtcggt ggatgacata ggcgagctgc aagtggagct ccccgaagtg cataccaaca     1860

gctgtgacaa catctcccag ttctctgtgg acagcatcac cagccaggag agcaaggagc     1920

ctgtgttcat tgcagcaggg gacatccgcc ggcgcctttc ggaacagctg gctcataccc     1980

cgacagcctt caaacgagac ccagaagatc cttctgcagt tgctctcaaa gagccctggc     2040

aggagaaagt acggcggatc agagagggct ccccctacgg ccatctcccc aattggcggc     2100

tcctgtcagt cattgtcaag tgtggggatg accttcggca agagcttctg gcctttcagg     2160

tgttgaagca actgcagtcc atttgggaac aggagcgagt gcccctttgg atcaagccat     2220

acaagattct tgtgatttcg gctgatagtg gcatgattga accagtggtc aatgctgtgt     2280

ccatccatca ggtgaagaaa cagtcacagc tctccttgct cgattacttc ctacaggagc     2340

acggcagtta caccactgag gcattcctca gtgcacagcg caattttgtg caaagttgtg     2400

ctgggtactg cttggtctgc tacctgctgc aagtcaagga cagacacaat gggaatatcc     2460

ttttggacgc agaaggccac atcatccaca tcgactttgg cttcatcctc tccagctcac     2520

cccgaaatct gggctttgag acgtcagcct ttaagctgac cacagagttt gtggatgtga     2580

tgggcggcct ggatggcgac atgttcaact actataagat gctgatgctg caagggctga     2640

ttgccgctcg gaaacacatg gacaaggtgg tgcagatcgt ggagatcatg cagcaaggtt     2700

ctcagcttcc ttgcttccat ggctccagca ccattcgaaa cctcaaagag aggttccaca     2760

tgagcatgac tgaggagcag ctgcagctgc tggtggagca gatggtggat ggcagtatgc     2820

ggtctatcac caccaaactc tatgacggct tccagtacct caccaacggc atcatgtgac     2880

acgctcctca gcccaggagt ggtggggggt ccagggcacc ctccctagag ggcccttgtc     2940

tgagaaaccc caaaccagga aaccccacct acccaaccat ccacccaagg gaaatggaag     3000

gcaagaaaca cgaaggatca tgtggtaact gcgagagctt gctgaggggt gggagagcca     3060

gctgtggggt ccagacttgt tggggcttcc ctgcccctcc tggtctgtgt cagtattacc     3120

accagactga ctccaggact cactgccctc cagaaaacag aggtgacaaa tgtgagggac     3180

actggggcct ttcttctcct tgtaggggtc tctcagaggt tctttccaca ggccatcctc     3240

ttattccgtt ctggggccca ggaagtgggg aagagtaggt tctcggtact taggacttga     3300

tcctgtggtt ggccactggc catgctgctg cccagctcta cccctcccag ggacctaccc     3360

ctcccaggga ccgacccctg gcccaagctc cccttgctgg cgggcgctgc gtgggccctg     3420

cacttgctga ggttccccat catgggcaag gaagggaatt cccacagccc tccagtgtac     3480

tgagggtact ggcctagcca tgtggaattc cctaccctga ctccttcccc aaacccaggg     3540

aaaagagctc tcaatttttt atttttaatt tttgtttgaa ataaagtcct tagttagcca     3600

cttgtgtcat ttccaggttt tctgggggag tgcaggggga gatgggtgat gaggtatgaa     3660

cggatgcctc agtgtccaag atacaaaagg cactacatag aagtttgctt tttccctgcc     3720

tgtcttggtc actaccacct cttccctgag aagggcgggc cttccatgtt ctctcacccg     3780

cttcaactcc acattgtcca agtcacagaa aaagagaggc ctgaatggag attcgaccac     3840

aaacagtttt aatggtctgg ttttctccct agttccccaa ctgtttgtta gtattattat     3900

tactacaaga ataaaggatt cctgagagcc tgtc                                 3934


<210> 1680
<211> 3983
<212> DNA
<213> Homo sapiens

<400> 1680
agattactat ggaatcggta gggtcctgac cgctggggaa gcaggaaagc gtatcctggg       60

aagaaaggct tggcttggac tccggagaag aatactacat cgagacctgc tggggaattt      120

tattttattt tattattttt ttggtcttgg ttgtactgag ggaggaagaa gaggttgtgt      180

ggcccggtcg aacttgtggc agcctgaagg ccccctcagg cggcgccgcg ggcagccccg      240

cagccggggc ctggtgcagc ctccgcggcc gctgtcaggg aagcgcaggc ggccaatgga      300

acccgggagc ggtcgctgct gctgaggcgg cagtgtcggc agtccaaccg cgactgcccg      360

caccccctcc gcgggggtcc cccagaggat caactaaacc ttgaactaag aagaaaaatg      420

tgttgtgagc agggggagcc tcagctgcct caggccgttc aggacagaag ggtgtttctg      480

aaggccggag caagttttga agaagtccct atcagattac acttggttga ctactccgga      540

gcagccacta agagggatga acaggcctgc gtggaaattg aatgagattc ttggaagctc      600

gaagtctggc tgtggccatg ggagatacag tagtggagcc tgcccccttg aagccaactt      660

ctgagcccac ttctggccca ccagggaata atggggggtc cctgctaagt gtcatcacgg      720

agggggtcgg ggaactatca gtgattgacc ctgaggtggc ccagaaggcc tgccaggagg      780

tgttggagaa agtcaagctt ttgcatggag gcgtggcagt ctctagcaga ggcaccccac      840

tggagttggt caatggggat ggtgtggaca gtgagatccg ttgcctagat gatccacctg      900

cccagatcag ggaggaggaa gatgagatgg gggccgctgt ggcctcaggc acagccaaag      960

gagcaagaag acggcggcag aacaactcag ctaaacagtc ttggctgctg aggctgtttg     1020

agtcaaaact gtttgacatc tccatggcca tttcatacct gtataactcc aaggagcctg     1080

gagtacaagc ctacattggc aaccggctct tctgctttcg caacgaggac gtggacttct     1140

atctgcccca gttgcttaac atgtacatcc acatggatga ggatgtgggt gatgccatta     1200

agccctacat agtccaccgt tgccgccaga gcattaactt ttccctccag tgtgccctgt     1260

tgcttggggc ctattcttca gacatgcaca tttccactca acgacactcc cgtgggacca     1320

agctacggaa gctgatcctc tcagatgagc taaagccagc tcacaggaag agggagctgc     1380

cctccttgag cccggcccct gacacagggc tgtctccctc caaaaggact caccagcgct     1440

ctaagtcaga tgccactgcc agcataagtc tcagcagcaa cctgaaacga acagccagca     1500

accctaaagt ggagaatgag gatgaggagc tctcctccag caccgagagt attgataatt     1560

cattcagttc ccctgttcga ctggctcctg agagagaatt catcaagtcc ctgatggcga     1620

tcggcaagcg gctggccacg ctccccacca aagagcagaa aacacagagg ctgatctcag     1680

agctctccct gctcaaccat aagctccctg cccgagtctg gctgcccact gctggctttg     1740

accaccacgt ggtccgtgta ccccacacac aggctgttgt cctcaactcc aaggacaagg     1800

ctccctacct gatttatgtg gaagtccttg aatgtgaaaa ctttgacacc accagtgtcc     1860

ctgcccggat ccccgagaac cgaattcgga gtacgaggtc cgtagaaaac ttgcccgaat     1920

gtggtattac ccatgagcag cgagctggca gcttcagcac tgtgcccaac tatgacaacg     1980

atgatgaggc ctggtcggtg gatgacatag gcgagctgca agtggagctc cccgaagtgc     2040

ataccaacag ctgtgacaac atctcccagt tctctgtgga cagcatcacc agccaggaga     2100

gcaaggagcc tgtgttcatt gcagcagggg acatccgccg gcgcctttcg gaacagctgg     2160

ctcatacccc gacagccttc aaacgagacc cagaagatcc ttctgcagtt gctctcaaag     2220

agccctggca ggagaaagta cggcggatca gagagggctc cccctacggc catctcccca     2280

attggcggct cctgtcagtc attgtcaagt gtggggatga ccttcggcaa gagcttctgg     2340

cctttcaggt gttgaagcaa ctgcagtcca tttgggaaca ggagcgagtg cccctttgga     2400

tcaagccata caagattctt gtgatttcgg ctgatagtgg catgattgaa ccagtggtca     2460

atgctgtgtc catccatcag gtgaagaaac agtcacagct ctccttgctc gattacttcc     2520

tacaggagca cggcagttac accactgagg cattcctcag tgcacagcgc aattttgtgc     2580

aaagttgtgc tgggtactgc ttggtctgct acctgctgca agtcaaggac agacacaatg     2640

ggaatatcct tttggacgca gaaggccaca tcatccacat cgactttggc ttcatcctct     2700

ccagctcacc ccgaaatctg ggctttgaga cgtcagcctt taagctgacc acagagtttg     2760

tggatgtgat gggcggcctg gatggcgaca tgttcaacta ctataagatg ctgatgctgc     2820

aagggctgat tgccgctcgg aaacacatgg acaaggtggt gcagatcgtg gagatcatgc     2880

agcaaggttc tcagcttcct tgcttccatg gctccagcac cattcgaaac ctcaaagaga     2940

ggttccacat gagcatgact gaggagcagc tgcagctgct ggtggagcag atggtggatg     3000

gcagtatgcg gtctatcacc accaaactct atgacggctt ccagtacctc accaacggca     3060

tcatgtgaca cgctcctcag cccaggagtg gtggggggtc cagggcaccc tccctagagg     3120

gcccttgtct gagaaacccc aaaccaggaa accccaccta cccaaccatc cacccaaggg     3180

aaatggaagg caagaaacac gaaggatcat gtggtaactg cgagagcttg ctgaggggtg     3240

ggagagccag ctgtggggtc cagacttgtt ggggcttccc tgcccctcct ggtctgtgtc     3300

agtattacca ccagactgac tccaggactc actgccctcc agaaaacaga ggtgacaaat     3360

gtgagggaca ctggggcctt tcttctcctt gtaggggtct ctcagaggtt ctttccacag     3420

gccatcctct tattccgttc tggggcccag gaagtgggga agagtaggtt ctcggtactt     3480

aggacttgat cctgtggttg gccactggcc atgctgctgc ccagctctac ccctcccagg     3540

gacctacccc tcccagggac cgacccctgg cccaagctcc ccttgctggc gggcgctgcg     3600

tgggccctgc acttgctgag gttccccatc atgggcaagg aagggaattc ccacagccct     3660

ccagtgtact gagggtactg gcctagccat gtggaattcc ctaccctgac tccttcccca     3720

aacccaggga aaagagctct caatttttta tttttaattt ttgtttgaaa taaagtcctt     3780

agttagccac ttgtgtcatt tccaggtttt ctgggggagt gcagggggag atgggtgatg     3840

aggtatgaac ggatgcctca gtgtccaaga tacaaaaggc actacataga agtttgcttt     3900

ttccctgcct gtcttggtca ctaccacctc ttccctgaga agggcgggcc ttccatgttc     3960

tctcacccgc ttcaactcca cat                                             3983


<210> 1681
<211> 1333
<212> DNA
<213> Homo sapiens

<400> 1681
gagcgacggg ccaattggag gagttgttgt taggccgtcc cggagacccg gtcgggaggg       60

aggaaggtgg caagatggtg ttggaaagca ctatggtgtg tgtggacaac agtgagtata      120

tgcggaatgg agacttctta cccaccaggc tgcaggccca gcaggatgct gtcaacatag      180

tttgtcattc aaagacccgc agcaaccctg agaacaacgt gggccttatc acactggcta      240

atgactgtga agtgctgacc acactcaccc cagacactgg ccgtatcctg tccaagctac      300

atactgtcca acccaagggc aagatcacct tctgcacggg catccgcgtg gcccatctgg      360

ctctgaagca ccgacaaggc aagaatcaca agatgcgcat cattgccttt gtgggaagcc      420

cagtggagga caatgagaag gatctggtga aactggctaa acgcctcaag aaggagaaag      480

taaatgttga cattatcaat tttggggaag aggaggtgaa cacagaaaag ctgacagcct      540

ttgtaaacac gttgaatggc aaagatggaa ccggttctca tctggtgaca gtgcctcctg      600

ggcccagttt ggctgatgct ctcatcagtt ctccgatttt ggctggtgaa ggtggtgcca      660

tgctgggtct tggtgccagt gactttgaat ttggagtaga tcccagtgct gatcctgagc      720

tggccttggc ccttcgtgta tctatggaag agcagcggca gcggcaggag gaggaggccc      780

ggcgggcagc tgcagcttct gctgctgagg ccgggattgc tacgactggg actgaaggtg      840

aaagagactc agacgatgcc ctgctgaaga tgaccatcag ccagcaagag tttggccgca      900

ctgggcttcc tgacctaagc agtatgactg aggaagagca gattgcttat gccatgcaga      960

tgtccctgca gggagcagag tttggccagg cggaatcagc agacattgat gccagctcag     1020

ctatggacac atctgagcca gccaaggagg aggatgatta cgacgtgatg caggaccccg     1080

agttccttca gagtgtccta gagaacctcc caggtgtgga tcccaacaat gaagccattc     1140

gaaatgctat gggctccctg gcctcccagg ccaccaagga cggcaagaag gacaagaagg     1200

aggaagacaa gaagtgagac tggagggaaa gggtagctga gtctgcttag gggactgcat     1260

gggaagcacg gaatataggg ttagatgtgt gttatctgta accattacag cctaaataaa     1320

gcttggcaac ttt                                                        1333


<210> 1682
<211> 1350
<212> DNA
<213> Homo sapiens

<400> 1682
ggtgaagagc gacgggccaa ttggaggagt tgttgttagg ccgtcccgga gacccggtcg       60

ggagggagga aggtggcaag atggtgttgg aaagcactat ggtgtgtgtg gacaacagtg      120

agtatatgcg gaatggagac ttcttaccca ccaggctgca ggcccagcag gatgctgtca      180

acatagtttg tcattcaaag acccgcagca accctgagaa caacgtgggc cttatcacac      240

tggctaatga ctgtgaagtg ctgaccacac tcaccccaga cactggccgt atcctgtcca      300

agctacatac tgtccaaccc aagggcaaga tcaccttctg cacgggcatc cgcgtggccc      360

atctggctct gaagcaccga caaggcaaga atcacaagat gcgcatcatt gcctttgtgg      420

gaagcccagt ggaggacaat gagaaggatc tggtgaaact ggctaaacgc ctcaagaagg      480

agaaagtaaa tgttgacatt atcaattttg gggaagagga ggtgaacaca gaaaagctga      540

cagcctttgt aaacacgttg aatggcaaag atggaaccgg ttctcatctg gtgacagtgc      600

ctcctgggcc cagtttggct gatgctctca tcagttctcc gattttggct ggtgaaggtg      660

gtgccatgct gggtcttggt gccagtgact ttgaatttgg agtagatccc agtgctgatc      720

ctgagctggc cttggccctt cgtgtatcta tggaagagca gcggcagcgg caggaggagg      780

aggcccggcg ggcagctgca gcttctgctg ctgaggccgg gattgctacg actgggactg      840

aagactcaga cgatgccctg ctgaagatga ccatcagcca gcaagagttt ggccgcactg      900

ggcttcctga cctaagcagt atgactgagg aagagcagat tgcttatgcc atgcagatgt      960

ccctgcaggg agcagagttt ggccaggcgg aatcagcaga cattgatgcc agctcagcta     1020

tggacacatc tgagccagcc aaggaggagg atgattacga cgtgatgcag gaccccgagt     1080

tccttcagag tgtcctagag aacctcccag gtgtggatcc caacaatgaa gccattcgaa     1140

atgctatggg ctccctggcc tcccaggcca ccaaggacgg caagaaggac aagaaggagg     1200

aagacaagaa gtgagactgg agggaaaggg tagctgagtc tgcttagggg actgcatggg     1260

aagcacggaa tatagggtta gatgtgtgtt atctgtaacc attacagcct aaataaagct     1320

tggcaacttt ttttcctttt ttgcttcaaa                                      1350


<210> 1683
<211> 1953
<212> DNA
<213> Homo sapiens

<400> 1683
ctctgtctct cagggcatga gaccagccag gcactgggaa acaaggtttg gtgccagaga       60

ttttggtggc ttccaagact gctttttcag agacaggctc atggacacag cacggattgc      120

agttgtcggg gcaggtgtgg tggggctctc cacggctgtg tgcatctcca aactggtgcc      180

ccgatgctcc gttaccatca tttcagacaa gtttactcca gataccacca gtgatgtggc      240

agccggaatg cttattcctc acacttatcc agatacaccc attcacacgc agaagcagtg      300

gttcagagaa acctttaatc acctctttgc aattgccaat tctgcagaag ctggagatgc      360

tggtgttcat ttggtatcag ggataaaggg aagtggaggc tggacactca ctcggcgaat      420

agaagacctg tgggaacttc atccgtcctt tgacatcgtg gtcaactgtt caggccttgg      480

aagcagacag cttgcaggag actcaaagat tttccctgta aggggccaag tcctccaagt      540

tcaggctccc tgggtggagc attttatccg agatggcagt gggctgacat atatttatcc      600

tggtacatcc catgtaaccc taggtggaac taggcaaaaa ggggactgga atctgtcccc      660

ggatgcagaa aatagcagag agattctttc ccgatgctgt gctctggagc cctccctcca      720

cggagcctgc aacatcaggg agaaggtggg cttgaggccc tacaggccag gcgtgcgact      780

gcagacagag ctccttgcgc gagatggaca gaggctgcct gtagtccacc actatggcca      840

tgggagtggg ggcatctcag tgcactgggg cactgctctg gaggccgcca ggctggtgag      900

cgagtgtgtc catgccctca ggacccccat tcccaagtca aacctgtaga tgacataaaa      960

tgacagcaaa gagactgaga gactgttgat caaagcacag aacaggttca aataactttt     1020

ccactgcatg aaagtttaat tagacatttc tttgttttca acattagaag tggtgtaaca     1080

tgtaagctga gcacggtggc atgcctatag tcccagctac ttgagaggct gaggcaggag     1140

gattgttgag cccaggagtt tgagtgcaat ctgggtaaca ttttttagag gtgccagttc     1200

ccacctctaa aaaaaacacc aacaacaaaa gaaatgatgc aacatgtagg cttacttagg     1260

aagtccagca ttaatggcat agggcataaa gctctatttt ttgttaaaaa tacttcttat     1320

agagtaaaat ttatttagaa ctgatgtcca aggacctatg cagatttata tgaatgttgg     1380

aagctataga gattttgata tcatttggct tataaatcca caggaggaga taatgtatgg     1440

aaaacattta aatcactgtc aattgcagag ctgcctgtga tcttcttagg ttatagccaa     1500

gtcagcaaca taattcctct aaataaaatt acattgtgct cacacagtgc tggattatta     1560

catttaattg aagacaaagc atgcttgctc ctagtactag cagcaagctt ttcctcccct     1620

cagctggtaa tgatggtagg agacagagat gaagttgcct atgtatgtca tatcaattca     1680

atagctgcct ggggtcaaac acctaggggt tgtacattcc attactgtaa atgattgaga     1740

gctggtttgt ggtatggttg gctttgccta agcatttttg aagatgaaca gcatgtgcag     1800

ccaaagaact aatttgctaa ttaaggtgga acaatcattc tgaatgaaat ataatcagag     1860

tactccgcag tttgttaaga agtattgggg aggaggggaa tgtgtctcac aataaaatga     1920

gttggaattg ttgagttaaa tgaatttaac ctg                                  1953


<210> 1684
<211> 2130
<212> DNA
<213> Homo sapiens

<400> 1684
ctctgtctct cagggcatga gaccagccag gcactgggaa acaaggtttg gtgccagaga       60

ttttggtggc ttccaagact gctttttcag agacaggctc atggacacag cacggattgc      120

agttgtcggg gcaggtgtgg tggggctctc cacggctgtg tgcatctcca aactggtgcc      180

ccgatgctcc gttaccatca tttcagacaa gtttactcca gataccacca gtgatgtggc      240

agccggaatg cttattcctc acacttatcc agatacaccc attcacacgc agaagcagtg      300

gttcagagaa acctttaatc acctctttgc aattgccaat tctgcagaag ctggagatgc      360

tggtgttcat ttggtatcag gttggcagat atttcagagc actccgactg aagaagtgcc      420

attctgggct gacgtggttc tgggatttcg aaagatgact gaggctgagc tgaagaaatt      480

cccccagtat gtgtttggtc aggcttttac aaccctgaaa tgtgaatgcc ctgcctacct      540

cccgtggttg gagaaaagga taaagggaag tggaggctgg acactcactc ggcgaataga      600

agacctgtgg gaacttcatc cgtcctttga catcgtggtc aactgttcag gccttggaag      660

cagacagctt gcaggagact caaagatttt ccctgtaagg ggccaagtcc tccaagttca      720

ggctccctgg gtggagcatt ttatccgaga tggcagtggg ctgacatata tttatcctgg      780

tacatcccat gtaaccctag gtggaactag gcaaaaaggg gactggaatc tgtccccgga      840

tgcagaaaat agcagagaga ttctttcccg atgctgtgct ctggagccct ccctccacgg      900

agcctgcaac atcagggaga aggtgggctt gaggccctac aggccaggcg tgcgactgca      960

gacagagctc cttgcgcgag atggacagag gctgcctgta gtccaccact atggccatgg     1020

gagtgggggc atctcagtgc actggggcac tgctctggag gccgccaggc tggtgagcga     1080

gtgtgtccat gccctcagga cccccattcc caagtcaaac ctgtagatga cataaaatga     1140

cagcaaagag actgagagac tgttgatcaa agcacagaac aggttcaaat aacttttcca     1200

ctgcatgaaa gtttaattag acatttcttt gttttcaaca ttagaagtgg tgtaacatgt     1260

aagctgagca cggtggcatg cctatagtcc cagctacttg agaggctgag gcaggaggat     1320

tgttgagccc aggagtttga gtgcaatctg ggtaacattt tttagaggtg ccagttccca     1380

cctctaaaaa aaacaccaac aacaaaagaa atgatgcaac atgtaggctt acttaggaag     1440

tccagcatta atggcatagg gcataaagct ctattttttg ttaaaaatac ttcttataga     1500

gtaaaattta tttagaactg atgtccaagg acctatgcag atttatatga atgttggaag     1560

ctatagagat tttgatatca tttggcttat aaatccacag gaggagataa tgtatggaaa     1620

acatttaaat cactgtcaat tgcagagctg cctgtgatct tcttaggtta tagccaagtc     1680

agcaacataa ttcctctaaa taaaattaca ttgtgctcac acagtgctgg attattacat     1740

ttaattgaag acaaagcatg cttgctccta gtactagcag caagcttttc ctcccctcag     1800

ctggtaatga tggtaggaga cagagatgaa gttgcctatg tatgtcatat caattcaata     1860

gctgcctggg gtcaaacacc taggggttgt acattccatt actgtaaatg attgagagct     1920

ggtttgtggt atggttggct ttgcctaagc atttttgaag atgaacagca tgtgcagcca     1980

aagaactaat ttgctaatta aggtggaaca atcattctga atgaaatata atcagagtac     2040

tccgcagttt gttaagaagt attggggagg aggggaatgt gtctcacaat aaaatgagtt     2100

ggaattgttg agttaaatga atttaacctg                                      2130


<210> 1685
<211> 2090
<212> DNA
<213> Homo sapiens

<400> 1685
ggagcaggtg gtcagcagtc tcttgaaacc aaagtttact gctttttcag agacaggctc       60

atggacacag cacggattgc agttgtcggg gcaggtgtgg tggggctctc cacggctgtg      120

tgcatctcca aactggtgcc ccgatgctcc gttaccatca tttcagacaa gtttactcca      180

gataccacca gtgatgtggc agccggaatg cttattcctc acacttatcc agatacaccc      240

attcacacgc agaagcagtg gttcagagaa acctttaatc acctctttgc aattgccaat      300

tctgcagaag ctggagatgc tggtgttcat ttggtatcag gttggcagat atttcagagc      360

actccgactg aagaagtgcc attctgggct gacgtggttc tgggatttcg aaagatgact      420

gaggctgagc tgaagaaatt cccccagtat gtgtttggtc aggcttttac aaccctgaaa      480

tgtgaatgcc ctgcctacct cccgtggttg gagaaaagga taaagggaag tggaggctgg      540

acactcactc ggcgaataga agacctgtgg gaacttcatc cgtcctttga catcgtggtc      600

aactgttcag gccttggaag cagacagctt gcaggagact caaagatttt ccctgtaagg      660

ggccaagtcc tccaagttca ggctccctgg gtggagcatt ttatccgaga tggcagtggg      720

ctgacatata tttatcctgg tacatcccat gtaaccctag gtggaactag gcaaaaaggg      780

gactggaatc tgtccccgga tgcagaaaat agcagagaga ttctttcccg atgctgtgct      840

ctggagccct ccctccacgg agcctgcaac atcagggaga aggtgggctt gaggccctac      900

aggccaggcg tgcgactgca gacagagctc cttgcgcgag atggacagag gctgcctgta      960

gtccaccact atggccatgg gagtgggggc atctcagtgc actggggcac tgctctggag     1020

gccgccaggc tggtgagcga gtgtgtccat gccctcagga cccccattcc caagtcaaac     1080

ctgtagatga cataaaatga cagcaaagag actgagagac tgttgatcaa agcacagaac     1140

aggttcaaat aacttttcca ctgcatgaaa gtttaattag acatttcttt gttttcaaca     1200

ttagaagtgg tgtaacatgt aagctgagca cggtggcatg cctatagtcc cagctacttg     1260

agaggctgag gcaggaggat tgttgagccc aggagtttga gtgcaatctg ggtaacattt     1320

tttagaggtg ccagttccca cctctaaaaa aaacaccaac aacaaaagaa atgatgcaac     1380

atgtaggctt acttaggaag tccagcatta atggcatagg gcataaagct ctattttttg     1440

ttaaaaatac ttcttataga gtaaaattta tttagaactg atgtccaagg acctatgcag     1500

atttatatga atgttggaag ctatagagat tttgatatca tttggcttat aaatccacag     1560

gaggagataa tgtatggaaa acatttaaat cactgtcaat tgcagagctg cctgtgatct     1620

tcttaggtta tagccaagtc agcaacataa ttcctctaaa taaaattaca ttgtgctcac     1680

acagtgctgg attattacat ttaattgaag acaaagcatg cttgctccta gtactagcag     1740

caagcttttc ctcccctcag ctggtaatga tggtaggaga cagagatgaa gttgcctatg     1800

tatgtcatat caattcaata gctgcctggg gtcaaacacc taggggttgt acattccatt     1860

actgtaaatg attgagagct ggtttgtggt atggttggct ttgcctaagc atttttgaag     1920

atgaacagca tgtgcagcca aagaactaat ttgctaatta aggtggaaca atcattctga     1980

atgaaatata atcagagtac tccgcagttt gttaagaagt attggggagg aggggaatgt     2040

gtctcacaat aaaatgagtt ggaattgttg agttaaatga atttaacctg                2090


<210> 1686
<211> 2143
<212> DNA
<213> Homo sapiens

<400> 1686
gaagatgagg ttacctccct tccacacctc cctccttgga ggcaagagct acaacagctg       60

agacagaaaa gaggtaagga agtgttgggg gctgggacaa ccagctcccc aacaactcct      120

aggtgtttaa agaaggaggc aggaagactt gtgaagatgg gaactataca agaggcagga      180

aaaaagacag atgttggggt cagggagatt gcagaagcac cagaactagg agcagccctg      240

agacatgggg agttggagct gaaggaggaa tggcaggatg aagaattccc tagattgctt      300

cctgaggagg ctggcacttc tgaagatcct gaagacccta aaggagattc acaggcagct      360

gcaggtaccc ccagcacttt agccctgtgt ggccagcgcc ccatgcgcaa gcgtctttct      420

gccccagagt tgcggctgag tctgactaag gggcctggaa atgatggagc ttcacccacc      480

cagtctgcac cttcctctcc tgatggcagt tctgacctgg agatagacga attggagaca      540

ccttcagact cggagcagct ggacagtgga catgaatttg aatgggaaga tgaactaccc      600

cgggcagagg gtctgggcac cagtgagaca gctgaaaggc tgggccgagg ttgtatgtgg      660

gatgtgactg gagaagatgg acatcactgg agggtgttcc gaatgggacc acgggagcag      720

cgcgtagaca tgactgtcat tgagccctat aagaaagtcc tgtctcatgg aggttaccac      780

ggtgatggcc tcaatgctgt catccttttt gcttcctgtt atctacccag aagcagcatc      840

cccaactaca cctatgtcat ggaacacttg tttaggtata tggtgggaac tctggagctg      900

ctagtagctg aaaattacct gcttgttcat ttgagtggag gcacaagcag ggcccaagtt      960

ccacctctaa gctggatacg tcagtgttac cgtaccctgg atcggcggct acggaaaaac     1020

ctgcgagccc tggtggttgt ccatgctaca tggtatgtga aagcatttct ggcactgctt     1080

cggcccttca tcagttccaa attcacacga aaaatccgtt ttctggacag cctgggggag     1140

ctggcccaac tcatatccct ggatcaagtc cacatccctg aagctgtcag acagctggac     1200

cgggatctcc atggctcagg agggacatag cacaggactg gataaaaggc cttagaacca     1260

gttagtgatc tgcctacacc tgaatccctg aaacatctga actgttttgt aaatcatctt     1320

atccccaacc tcagtaccac cggatcttca cttctcagtg ggattttgtc ctttgcatga     1380

ccctactttc agcagggctt tgaggctggg aaactgatct gctgggtgac tttcattcca     1440

gttgctggga cggaaggctg aatgtagggt cattttgtat gggatatgca gagctctggg     1500

tttttttgtt ttttgttttt tgagacggag tctcgctctg tcgccaggct ggagtgcagt     1560

ggtgcgatct cggctcactg caacctccgc ctcccggttc aagccattct tctgcctcag     1620

cctcagcgag tagctgagac taccggcgca cgccaccacg cccagctaat tgttttgtat     1680

ttttagtaga gacggggttt caccatgttg gccaggatgg tctcgatctc ttgacctcgt     1740

gatctgcccg cctcggcctc ccaaagtgcc gagattacag gtgtgagcca ccgcgctcgg     1800

ccagagctct gggttttaat cctactttag ctgtagaacc ttgggcaaat aacttcatct     1860

ttttgggtcc taattttcct cctgtctaac tggagggact gtgatccttc caccttggat     1920

ggaagaggct tacctgacag ccagcctgcc tgctgggagc caggagagtc agctcattaa     1980

atcttgaaga accgctgtat gccctttttc cttctaagtc atgtctgctg cctgtgagcc     2040

tgggaaggag tgctttcaaa acctgtattt ttgccctctt tagtaaattt agaactgtag     2100

aggctaataa actgcgatga gacatttaag ctctgctcca aag                       2143


<210> 1687
<211> 1998
<212> DNA
<213> Homo sapiens

<400> 1687
attgtggggt ggcggcggcg gccgcgctag cgacgcgggg ccgggcggct gagcgttcgc       60

ggggccgagg ccatggcttt ctgggcgggg ggttcgccca gcgtcgtgga ctatttccct      120

agcgaggact tctaccgctg cggctactgc aagaacgagt cgggcagccg ctccaatggt      180

gccgaccttt acaatttcag ccttcaaaat ctcacaagaa ggttttgaaa aaaatgttga      240

aatttctagc taaaggggag gttcccaaag gaagttgtga ggatgagccc atggattcca      300

caatggatga tgctgttgcg ggtgactttg cattgataaa taaactggat atacagtgtg      360

atcttaaaac actcagtgat gacatcaaag agagtttaga gagtgaagga aaaaattcaa      420

agaaagaaga acctcaggaa ttacttcagt cacaagattt cgtaggagag aagttgggct      480

ctggtgaacc gtcacattca gttaaagttc acacagttcc taagccaggc aaaggggctg      540

atttgagtaa gcctccatgt cgaaaagcaa aggaaatccg gaaagaaagg aaaaggttaa      600

aactaatgca gcagaaccca gctggagaac ttgagggttt ccaggctcaa ggtcacccac      660

catctttgtt tccaccaaag gctaaatcca accagccaaa atcactcgaa gatttaattt      720

ttgagtcttt accagagaat gcatcacaca agttagaggt gaggttagta cctgtctcct      780

ttgaggaccc agagttcaag tcgtctttca gccagtcctt ttctttgtat gtcaagtatc      840

aagtggccat acaccaggat ccacccgatg aatgtgggaa gactgagttc acaagattcc      900

tttgcagttc acccttggag gcagagactc cccctaatgg gccagattgt ggctatggct      960

cctttcacca gcagtactgg cttgacggaa agatcattgc tgtgggggtg attgacatcc     1020

tcccaaactg tgtatcatct gtgtatttgt actacgatcc tgattattcg tttttgtctt     1080

tgggcgtcta ctctgcacta cgagaaattg cttttactag gcagcttcat gagaaaactt     1140

ctcaactcag ctattattat atgggtttct acattcattc atgtcccaag atgaaatata     1200

agggtcagta tagaccttct gatttgctgt gccctgagac atatgtttgg gtacccattg     1260

agcaatgcct gccttcactt gaaaactcca agtactgccg tttcaaccag gacccagaag     1320

cagtggatga ggatcgcagt acggaacctg accgattgca ggtgtttcac aagagagcca     1380

tcatgcctta cggtgtttat aagaaacagc agaaagaccc aagtgaggag gctgctgttc     1440

tgcagtacgc cagcctggtg gggcagaagt gctccgagcg gatgctgctg ttcagaaact     1500

gacctgttca cctctgccgg gaagttcctg tgttgtgctg atgatttgtg ccaggataca     1560

tattcagtac ctgtggggaa ataactgtca ccacccacaa attagacatt ttttattttg     1620

actatctatg gcttttaaaa aatattttgt ggcaatgtat ctgtgagaat ctcatagtta     1680

atataaagat tttaaaactg cattatgacc tagcccccat aattgggatt tatcattttg     1740

gaggattctt tctagagcaa gatacgctca aattctcctg tttgtatttt gtaaaatgaa     1800

gaagtgaatc taagtaactt aatcacagtt gtgcattttt tttggttctg ttagagaaat     1860

taaaacagac tgtttcctca ggcccatttt aaactgaact tatgctagga aaccttaagt     1920

atggggaagg tagaaagttc atttcatcac ttagaaaata tgtcttctca agaacaaaac     1980

tgtgctgtta caactcag                                                   1998


<210> 1688
<211> 4900
<212> DNA
<213> Homo sapiens

<400> 1688
cgggcggcgc gctgcattgt ggggtggcgg cggcggccgc gctagcgacg cggggccggg       60

cggctgagcg ttcgcggggc cgaggccatg gctttctggg cggggggttc gcccagcgtc      120

gtggactatt tccctagcga ggacttctac cgctgcggct actgcaagaa cgagtcgggc      180

agccgctcca atggcatgtg ggcacattcc atgacagtac aggattatca ggatctcata      240

gaccgaggat ggcgaagaag tggaaaatat gtgtacaaac ctgtcatgaa tcaaacatgt      300

tgtcctcagt acacaataag gtgccgacct ttacaatttc agccttcaaa atctcacaag      360

aaggttttga aaaaaatgtt gaaatttcta gctaaagggg aggttcccaa aggaagttgt      420

gaggatgagc ccatggattc cacaatggat gatgctgttg cgggtgactt tgcattgata      480

aataaactgg atatacagtg tgatcttaaa acactcagtg atgacatcaa agagagttta      540

gagagtgaag gaaaaaattc aaagaaagaa gaacctcagg aattacttca gtcacaagat      600

ttcgtaggag agaagttggg ctctggtgaa ccgtcacatt cagttaaagt tcacacagtt      660

cctaagccag gcaaaggggc tgatttgagt aagcctccat gtcgaaaagc aaaggaaatc      720

cggaaagaaa ggaaaaggtt aaaactaatg cagcagaacc cagctggaga acttgagggt      780

ttccaggctc aaggtcaccc accatctttg tttccaccaa aggctaaatc caaccagcca      840

aaatcactcg aagatttaat ttttgagtct ttaccagaga atgcatcaca caagttagag      900

gtgaggttag tacctgtctc ctttgaggac ccagagttca agtcgtcttt cagccagtcc      960

ttttctttgt atgtcaagta tcaagtggcc atacaccagg atccacccga tgaatgtggg     1020

aagactgagt tcacaagatt cctttgcagt tcacccttgg aggcagagac tccccctaat     1080

gggccagatt gtggctatgg ctcctttcac cagcagtact ggcttgacgg aaagatcatt     1140

gctgtggggg tgattgacat cctcccaaac tgtgtatcat ctgtgtattt gtactacgat     1200

cctgattatt cgtttttgtc tttgggcgtc tactctgcac tacgagaaat tgcttttact     1260

aggcagcttc atgagaaaac ttctcaactc agctattatt atatgggttt ctacattcat     1320

tcatgtccca agatgaaata taagggtcag tatagacctt ctgatttgct gtgccctgag     1380

acatatgttt gggtacccat tgagcaatgc ctgccttcac ttgaaaactc caagtactgc     1440

cgtttcaacc aggacccaga agcagtggat gaggatcgca gtacggaacc tgaccgattg     1500

caggtgtttc acaagagagc catcatgcct tacggtgttt ataagaaaca gcagaaagac     1560

ccaagtgagg aggctgctgt tctgcagtac gccagcctgg tggggcagaa gtgctccgag     1620

cggatgctgc tgttcagaaa ctgacctgtt cacctctgcc gggaagttcc tgtgttgtgc     1680

tgatgatttg tgccaggata catattcagt acctgtgggg aaataactgt caccacccac     1740

aaattagaca ttttttattt tgactatcta tggcttttaa aaaatatttt gtggcaatgt     1800

atctgtgaga atctcatagt taatataaag attttaaaac tgcattatga cctagccccc     1860

ataattggga tttatcattt tggaggattc tttctagagc aagatacgct caaattctcc     1920

tgtttgtatt ttgtaaaatg aagaagtgaa tctaagtaac ttaatcacag ttgtgcattt     1980

tttttggttc tgttagagaa attaaaacag actgtttcct caggcccatt ttaaactgaa     2040

cttatgctag gaaaccttaa gtatggggaa ggtagaaagt tcatttcatc acttagaaaa     2100

tatgtcttct caagaacaaa actgtgctgt tacaactcag tgttcaatgt gaaattgctg     2160

ccaaatgtta tgtagtttaa tagagaactt gaaaaaataa aacattaaaa tggagcttgt     2220

gttagcatca ggtatccatt tgttcaggac agtcctgttc atgtctgttg tcttggcata     2280

gttttttccc ctagaatata gtactccctt ttactctaaa aaatatccca gtttggacaa     2340

taaaatacat aattactcta gttatattat ttgctttact tctaaaaatg taagaaattg     2400

aattttttta aagaaaaatg ttggttcctg ccttgatcta agtctcatcc aaaggaaata     2460

aatagtcact agttttttat cttacaactc aggacatttg tctttggtta ttaatggaaa     2520

ttagtatgtg attactttca tagttatgcc acaaatcaca ttgaagaagg aatcattccg     2580

acctctgttc caggacaaga gctagaacaa tccatttctt gtcctttgat ttgagagtca     2640

cagtcagggt ggcttctgcc acccttagta actcagagca gaggccagcc ccctccttcc     2700

ctcactttct tttgctgagt cctttgccca cctgtcaagg tggcaggcac tgtgctgggt     2760

acaggaggac agtcagacat gtcccttctt agctatagtc gagctgtctg ggaaacagga     2820

tgaaaaacag gagggttatt ttcttgtgcc ctctttgtca gctgatcccc tcttctgcta     2880

ccagctattt ggccagcaag ccgtttttag tccccacttt gcccattttt ctgttttggt     2940

tcatcgtttc ttaaaagcca tgttataaaa catggtagtt tgaatcctgt tgctaatttt     3000

aaactttcct ctaaaatgta ctgaattttg acaaaaattt gaaaatatcc tcagctaact     3060

agaataaaaa ggatcataaa acaatgattt taaaactgaa atctctagaa actcaacatc     3120

caagtcagcc gcatttcttc attcagagtg tgtgtgtcac acctgccaag gtgctgcgta     3180

ctctgctaac cgagctagag tagtgagcaa agccattttc tctgatcaca agattttaca     3240

tttttctggg attttgacct gcaaagtagt ctcgtaagag catttgagag acttacttgg     3300

aactgccttc agaatctata gagccttttt tctctttttc ctctaaaatg aaaagagctt     3360

cattttatga ttataacaaa agtgacactg taagcagtta gaacattaag aagtataaat     3420

aaaaagtaaa aatcatctac aaccctacca tactcagaag gagaaaagaa ctgtcatgta     3480

tgtatacaca catacctatg taattttaat ataaatagaa ttatgttcta catgctgttt     3540

tatttcctca acagtaaatt atggacatgt ctgaaatgtg aaataaattt caaaataagg     3600

cttcagaaag tgtagtaagt aatctctgca ttattaaaaa taagcagggt agggctggta     3660

cttggctcgc ttagcatttg aatgtccaac ttggtgttat cactgtatct tccctccatt     3720

tgtctttgtg attagcatgt aaaatggtat tcataaagat cacaaccctt gaatatcaga     3780

tgaagagaaa acttgactcc aacatcttac cacaactctg gtttcttcct gcagaattca     3840

ttttcagagg aaaatgatga atcatccctg tctgtgaacc actgtgcttt ccttgagggt     3900

ggcattgtag gttgacacca gcaaagactc agagtgactt gagcattgga gatccttcta     3960

cttggctgct gtattcatgc attatgttgg tttgagaata gctagtgtat tgatccaagt     4020

agtcaaagtg tcttaaaagg acacctattt gtccttttga gccccagctg agtgaatact     4080

gatagtggac tagaaaagca tagtcaagaa aagtgaccca ccttgttact tgaccagcag     4140

tctagctgag agatctgatt ttatgttcgt aactttctgt aaagaaagac acaaggactt     4200

ttcaaagaca gtttatatct ttccaaggca ggaagctttg catttgcaat cttagtgttg     4260

tgtccctttc tgattttcaa atacatcaca cctgccttcc tgttttggga gcaaagatgt     4320

aatttcaatt ccccttgcta ccgtccttat ttaaattatt tccattctaa gagatttttg     4380

ttattttttt aaatgtaatc tgagcacttt tttgtattct aaaagataga tgatatcaga     4440

taaatatgtt gtacatttga ttaaaattat ttagataaat attactatgt tgacttttaa     4500

atagctttat cctatttttc attcattttg caaatatttg ttgtgtgtag tttcttaacg     4560

tgtcagaatc tattatgtaa aagaaccttt ccagatttct gaacagtata tgctttgatt     4620

ttataggctt tatattattt cagtatgaat aaagataagg aatatgaaac agttaactaa     4680

aatgtatctg tcgttgctaa cttgaaaaat gaagtagaaa cagttggaaa atgtttgaat     4740

tagaagttat tcaagtgcac actcttttct aaaagaaagc caatgactat aaggcaaaag     4800

aagtttgact gcatgtggta ttttttgctc ttgtatatgc tttttgaaca agctatttga     4860

taaagcctga atggaaaaaa taaagctgtt tctatctgca                           4900


<210> 1689
<211> 4656
<212> DNA
<213> Homo sapiens

<400> 1689
gcgtgatcgg tttccggtca gtggtgtggt accgggtacc cggagacgtg tatcggacgg       60

tgggccgcag ccatggccga gagaaaacct aacggtggca gcggcggcgc ctccacttcc      120

tcatcgggca ctaacttact tttctcctcc tcggccacgg agttcagctt caatgtgccc      180

ttcatcccag tcacccaggc ctccgcttct ccggcctccc tgctcttacc gggagaggat      240

tccacagatg ttggtgagga ggacagcttc cttggtcaga cttctattca cacatctgcc      300

ccacagacat ttagttactt ctctcaggta tcaagcagca gtgatccttt tgggaatatt      360

ggacagtcac cattaacaac tgcagcaacc tcagttggac aatcaggatt ccccaagccc      420

ctgactgctc tcccttttac aactggatcc caagatgtct cgaatgcatt ttcaccatcc      480

atttcgaagg ctcaacctgg tgctccacct tcctcactga tgggaataaa ttcttatctg      540

ccttctcagc caagtagtct ccctccttca tattttggga accaacccca aggaattccc      600

caaccaggat acaatccata tcgccatacc cctggcagca gcagggctaa tccttacatt      660

gcaccacccc agctgcagca gtgccaaaca ccaggccctc ctgctcatcc tccaccttct      720

ggaccccctg ttcagatgta ccagatgcct ccaggatctt tgccaccggt tccttcttca      780

gtgcagtcac cggcacagca gcaggtacct gccagacctg gggctccctc tgttcaagtg      840

ccatctcctt ttctacttca aaaccaatat gagcctgttc agccccactg gttttactgc      900

aaggaggtag aatacaaaca actgtggatg ccttttagtg tgttcgactc tttgaatctt      960

gaagaaatct ataattcagt tcagccagat ccggagagcg tggttcttgg cacggatgga     1020

gggcgctacg atgtttacct ctatgaccga ataaggaagg ctgcctactg ggaagaggag     1080

ccagccgaag tgagacgctg tacttggttt tacaaggggg acacagatag tcgatttatt     1140

ccctatactg aggagttcag tgaaaaacta gaggctgaat ataaaaaagc tgtaaccact     1200

aatcagtggc accgaagatt agagtttcca agtggagaga caattgttat gcacaatcca     1260

aaggttattg ttcagttcca gccctcctca gtgccagatg aatggggcac cacgcaagat     1320

ggacagacaa ggcccagggt tgtaaagcgt ggaattgatg ataaccttga tgaaattccc     1380

gacggggaga tgcctcaagt tgaccatttg gtgtttgtgg tgcatggcat tggacctgtg     1440

tgtgacttac gctttaggag cattattgag tgtgtggatg attttagggt ggtttctctc     1500

aaattgctgc ggacacattt caagaaatct ttagatgacg ggaaagtaag cagagtggag     1560

ttccttccag ttcattggca tagttctttg ggtggggacg ccacaggtgt ggacaggaat     1620

attaagaaaa tcactttgcc aagtattggt cgatttcgtc actttaccaa tgaaactttg     1680

ctagatattt tattttataa cagccccacc tactgtcaga caattgtgga aaaagtagga     1740

atggagataa accatctgca tgcactcttt atgagtcgga acccagactt caaaggaggt     1800

gtctctgttg ctggtcacag tttaggttct ttaatattgt ttgacatcct gtctaatcaa     1860

aaagatttga atttatcaaa gtgccctgga cctcttgctg ttgctaatgg agttgtgaag     1920

cagctacatt ttcaggaaaa gcagatgcct gaagagccaa agctgacttt ggatgagtcg     1980

tatgaccttg ttgttgaaaa taaagaagtc ctaactttgc aagaaactct ggaagcactt     2040

agcctctctg aatattttag cacttttgaa aaggaaaaga ttgatatgga gtccctgctt     2100

atgtgtacag ttgatgacct gaaggaaatg gggatacccc ttggacccag aaagaagata     2160

gctaactttg tagaacataa agcagccaaa ctgaaaaaag cagcgtcaga aaagaaggca     2220

gtggcggcca cttctacaaa aggacaagag caaagtgccc agaagactaa agacatggct     2280

tccctcccct cagaatccaa tgagccaaag aggaaacttc cagttggtgc ttgcgtgtct     2340

tctgtgtgtg tgaattatga atcttttgaa gttggcgccg gacaggtttc tgttgcttac     2400

aactcattag attttgaacc agagatattc tttgccttgg ggtctccaat tgctatgttt     2460

ctcactattc gaggagttga taggatagat gagaattaca gccttcctac ctgtaaaggg     2520

ttcttcaata tttatcatcc gcttgatcca gtggcatata gattagaacc tatgattgtt     2580

ccagatttgg acctaaaagc tgttctcatt ccacatcaca aaggcagaaa aagacttcat     2640

ttagaattga aagagagtct ctctcgtatg ggatctgatt tgaagcaggg ttttattagc     2700

tctctcaaaa gtgcttggca gacattaaat gagtttgccc gtgctcatac gtcttcaacc     2760

cagttgcaag aagaattgga gaaggtggcc aatcagatca aagaagaaga agaaaagcaa     2820

gtagttgaag cagaaaaggt tgttgaaagt ccagattttt ccaaggatga ggactactta     2880

ggaaaggttg gaatgttaaa tggaggccgc cgaattgact acgttctcca agaaaaacca     2940

atagagagtt ttaatgaata ccttttcgct cttcagagtc acttatgcta ttgggaatct     3000

gaagatactg ctctgttact acttaaagaa atttatcgaa caatgaacat tagtccagaa     3060

cagccccagc attgatcaaa cttcagtttt actgtacttt cttgtctgca cagaaagtcc     3120

cagtacaact tccattgctg agaaaatcct cagaggactt tcccacttcg ctcctgtgat     3180

ggatgacaga agagtgattc attaacaatt gctcagccac aattctcgga tatagggatt     3240

caaaagacag gacacagaac taacacagtg aaaaaaatca gtaccacatt tggacagtat     3300

aggtgagaaa acataattat aaaaatgatg ccatgaaaaa ttccacagat cagtttagtt     3360

gtatagttgt caaagttata tgtgatatca atgaagaaat atttgtagca tgtaaacggt     3420

tatttctgtt tcttaaaaag tattgttagt gggctattaa acttggattt ttctttttat     3480

taatgcagta tgttcttttt attcaagtat gaacttgttg agaaactata gtaatatgat     3540

ttttaagaga tttatgttct acttaaaatg tgaattgtac ttctgagctg ccttaatgca     3600

aggtcattta tatttgttaa gaggaaataa tcaagatcac tcatatccca actgaatctg     3660

aggttttata aatccctcaa acgattgctg agagcctgat tgtggaaaga agtgagatgc     3720

accttatttt caagaagtcc tgggaagcgc tctcctagca cgtccatttc caggaggaga     3780

agcaagcaga tgagaggttt tccattttgt catccaaggt agctgtgcac ttgccttgtt     3840

gctgaagttc caataatgtg aaaaccaaag tagaggtttt tttcttcttc tttttgtttt     3900

ctattaattt cacttatacc aaagtgtttg aaagtatgaa atgtgttgct tctgagttat     3960

ataaggctac ttcatgacaa gactgctttg taatatttca ctttgtttta ctacaaattc     4020

agatcacttt gttttactat aaattcagat tatccaaata ttttcctaat actatgtggg     4080

aatgctgatt ttcttttgtt acgtagtgga aacattttgc attgtttaca tagttctcat     4140

ggaacatgga aatttttgaa agtgatatat gatacacatt ttttgtgtat gtattctaat     4200

tagtgtgaat aaagcagtaa cattaatgca ttttttaagc agcaaactta tgtatttctc     4260

ttgtcttcct taaaagtgtc cccatgaact cagtgtttat tcccttttca ttttgagtac     4320

ctgcttatat ggtcagtatg taacgttagc attggctcct aatggtagaa ttagaacagc     4380

aagattgtag agctgtaatt gactccagac aacatagatt tcagccacct cattctacag     4440

ctgaggccag gacaataaat gcctttccca gactgggtag tggcagatct gggatggaat     4500

atggttttct tgattccctt tcagccttca tttctctctc tcaggactac tactttttaa     4560

ttacttttca cttaatttcc caatactgat gaaataaaga aaaatgaggg ttatttatat     4620

acatttcaat aaaatccaat ttgatttttc aactta                               4656


<210> 1690
<211> 785
<212> DNA
<213> Homo sapiens

<400> 1690
actataaaga cagtaaaaag atcagtggtt atctttgcag acgccaccat cactgtgagc       60

cctgtactat cagccatggt caactccgtc gtcttttttg acatcaccgt cgacggcaag      120

cccttgggcc gcatctccat caaactgttt gcagacaaga ttctaaagac agcggaaaac      180

tttcgtgctc tgagcactgg agagaaagga tttcgttata agggttcctg ctttcacaga      240

attattccag ggtttatgtg tcagggtggt gacttcacac gccataatgg cactggtgac      300

aagtccatct atggggagaa atttgatgat gagaacctca tccgaaagca tacaggttct      360

ggcatcttgt ccatggcaaa tgctggaccc aacacaaatg gttcccagtt tttcatctgt      420

gctgccaaga ctgagtggtt ggatggcaag catgtggcct ttggcaaggt gaaagaacgt      480

gtgaatattg tggaagccat ggagcacttt gggtacagga atagcaagac cagcaagaag      540

atcaccattg ctgactgtgg acaattctaa tgagtttgac ttgtgtttta ttttcaccac      600

cagacccatt ccttctgtag ctcaggagag cacccctcca ccacatttgc ttgcaatatc      660

ctagaatctt ggtgctcttg ctgcagttcc ctttgggttc catgttttcc ttgttccctt      720

ccatgcctag ctggattgca gagttgagtt aagtttatga ttatgaaata aaaactaagt      780

aacaa                                                                  785


<210> 1691
<211> 646
<212> DNA
<213> Homo sapiens

<400> 1691
cagccaggaa aacctttgtt ggggatgaag attcttgacg ttggctgtgg tggtgggctg       60

ttaactgaac ccggtggttc tttattcatt actacaatca acaaaacaca actttcctat      120

gccttgggaa ttgttttttc agagcaaatt gcaagtattg taccaaaagg tactcataca      180

tgggagaagt ttgtttcacc tgaaacacta gagagcattc tggaatcaaa tggtctgtca      240

gttcaaacag tggtaggaat gctctataac cccttctcag gttactggca ttggagtgaa      300

aataccagcc ttaactatgc agcttatgct gtgaaatcca gggtccagga acacccagcc      360

tctgctgagt ttgttttaaa gggagaaaca gaagagctcc aagctaatgc ctgcaccaat      420

ccagctgtgc atgaaaagct gaagaaatga attgtttctg agaactatag taatatggct      480

tggatatctg atgttttcaa atacaaaaat gtacaattta tcctttgaga gagaatcatg      540

aagaaaagaa ggtcaataaa aagggctaaa accttggaca aaagtttttg ttatttcgtc      600

taatagctac tttcaaggga ttctgtgaat aaaaagtttt gtcaag                     646


<210> 1692
<211> 1092
<212> DNA
<213> Homo sapiens

<400> 1692
aaaagaggtg ggatcgtttg tcgcgatgtg gagtggccgt aagctgggct cctccggggg       60

ttggttttta agagtgctgg ggcctggagg ctgtaataca aaagctgcgc gtcccttaat      120

ttcctcggcg gtttatgtga agaaccagct cagtgggact ctacagatta aaccaggggt      180

tttcaatgaa tacagaacca tatggttcaa atcctacagg acgatctttt cctgtttgaa      240

cagaataaag agtttcaggt acccttgggc gagactgtac agtacttccc aaaccactgt      300

cgacagcggt gaggtaaaaa ccttcttggc cctggctcac aaatggtggg atgaacaagg      360

agtatatgca cctcttcatt ccatgaatga cctgagggtg ccatttatta gggacaatct      420

tctgaaaaca attcctaatc accagccagg aaaacctttg ttggggatga agattcttga      480

cgttggctgt ggtggtgggc tgttaactga acccggtggt tctttattca ttactacaat      540

caacaaaaca caactttcct atgccttggg aattgttttt tcagagcaaa ttgcaagtat      600

tgtaccaaaa ggtactcata catgggagaa gtttgtttca cctgaaacac tagagagcat      660

tctggaatca aatggtctgt cagttcaaac agtggtagga atgctctata accccttctc      720

aggttactgg cattggagtg aaaataccag ccttaactat gcagcttatg ctgtgaaatc      780

cagggtccag gaacacccag cctctgctga gtttgtttta aagggagaaa cagaagagct      840

ccaagctaat gcctgcacca atccagctgt gcatgaaaag ctgaagaaat gaattgtttc      900

tgagaactat agtaatatgg cttggatatc tgatgttttc aaatacaaaa atgtacaatt      960

tatcctttga gagagaatca tgaagaaaag aaggtcaata aaaagggcta aaaccttgga     1020

caaaagtttt tgttatttcg tctaatagct actttcaagg gattctgtga ataaaaagtt     1080

ttgtcaagat at                                                         1092


<210> 1693
<211> 7606
<212> DNA
<213> Homo sapiens

<400> 1693
gtcattgagc tgatgtgctt ttgcaagggg tctctttaga agtggtaggg gcagggtcga       60

gagaagaagg ggatgcagaa tctgtacatg aggaaggagc cagagtcact caggaaactc      120

ctcattcttc ctgcgctggc tgtggcacac ccaccggtgg cacacccctc cctcgggtcc      180

agttcagccc acagactcct gggaggagag ccagggcccc agcctctcct ttgaggagtg      240

ttgcagcctt tctgtgtgcc agatgcctag tgaagaaaag ctgaaaccct ggagctttgt      300

gcatgttaat gaccttggaa atgactgagc tcacggaccc tcatcacacc atgggagact      360

acaaagtggc ccaccctcag gaccctcacc acccatcaga gaagcctgtc attcactgcc      420

ataaatgtgg ggagccttgc aagggtgaag tgcttcgggt ccagaccaaa catttccaca      480

tcaagtgttt cacctgcaaa gtgtgtggct gtgacctggc acaagggggc ttcttcataa      540

agaacggaga gtatctctgc accctggact accagcggat gtacgggaca cgctgccatg      600

gctgtgggga gttcgtggag ggcgaagtgg tgactgctct gggcaagacc taccatccca      660

attgctttgc ttgtactatc tgcaagcgcc cgtttccacc cggagaccga gtcacattca      720

atgggagaga ctgcctttgt caactctgtg cacagccgat gtcgtccagt ccgaaagaaa      780

ccaccttctc cagcaattgt gccggctgcg gaagagatat caagaatggg caggcgctgc      840

tggcgctgga taagcagtgg cacttggggt gctttaaatg caagtcctgc gggaaggtcc      900

tcaccgggga gtacatcagc aaggatggtg ctccgtactg tgaaaaggac taccagggac      960

tctttggggt gaaatgtgag gcgtgtcacc agtttatcac agggaaagtc ctggaggcag     1020

gtgacaaaca ttaccacccc agctgtgcac gatgcagcag atgcaaccag atgttcacag     1080

aaggagagga aatgtatctt caaggctcca ccgtttggca tcccgactgt aagcaatcta     1140

cgaagaccga ggaaaagctg cggcctacca ggacatcctc ggaaagtatt tattctaggc     1200

caggctccag tattcctggc tcaccaggtc atactatcta tgcaaaagta gacaatgaga     1260

tcctggatta caaggattta gcagccattc cgaaggtcaa ggcaatttat gacattgaac     1320

gtccagatct tattacctat gagcctttct acacttcggg ctatgatgac aaacaggaga     1380

gacagagcct tggagagtct ccgaggactt tgtctcctac tccatcagca gaagggtacc     1440

aggatgttcg ggatcggatg atccatcggt ccacgagcca gggctccatc aactcccctg     1500

tgtacagccg ccacagctac actccaacca cgtcccgctc tccccagcat ttccacagac     1560

ctggcaatga gccgtccagc ggccggaact cccctctccc ttaccggcca gacagccgcc     1620

ctctaactcc aacttacgct caggccccta aacatttcca tgttccagat caaggaatca     1680

acatttaccg aaagccaccc atctacaaac agcatgctgc cttggcagcc cagagcaagt     1740

cctcagaaga tatcatcaag ttttccaagt tcccagcagc ccaggcacca gaccccagcg     1800

agacaccaaa gattgagacg gaccactggc ctggtccccc ctcatttgct gtcgtaggac     1860

ctgacatgaa acgcagatct agtggcagag aggaagatga tgaggaactt ctgagacgtc     1920

ggcagcttca agaagagcaa ttaatgaagc ttaactcagg cctgggacag ttgatcttga     1980

aagaagagat ggagaaagag agccgggaaa ggtcatctct gttagccagt cgctacgatt     2040

ctcccatcaa ctcagcttca catattccat catctaaaac tgcatctctc cctggctatg     2100

gaagaaatgg gcttcaccgg cctgtttcta ccgacttcgc tcagtataac agctatgggg     2160

atgtcagcgg gggagtgcga gattaccaga cactcccaga tggccacatg cctgcaatga     2220

gaatggaccg aggagtgtct atgcccaaca tgttggaacc aaagatattt ccatatgaaa     2280

tgctcatggt gaccaacaga gggcgaaaca aaatcctcag agaggtggac agaaccaggc     2340

tggagcgcca cttagcccct gaagtgtttc gggaaatctt tggaatgtcc atacaggagt     2400

ttgacaggtt acctctttgg agacgcaacg acatgaagaa aaaagcaaaa ctcttctaag     2460

tcccactcgt gaatggcaat tagagaaagg actgacagtg gcggtgcccc ataggatgtc     2520

atattgaggc ccaaacttga ttggagaatt tgcaaactac cgtcgctcag caacaccaaa     2580

aagagaaagt ctggttaaaa caccatgagt caaatgtcgg gccagccaac agtaacactt     2640

gccaagaagc atggcgtaga aatttctatg ttccgaaaca cagagtagtg tccacatgtg     2700

agcttttcac attaccttat gtatacaaca ggagctgcgt tgttttcttc tttttctttt     2760

cctttatctg ttgtccaaca acagtgctga ctgtccggat aagagctggc aagtgccctt     2820

aggatgccgc atgggaaaaa tcggttatca taatttcaaa gtataaatat atttattaag     2880

tagcgctgcg gctaagaagg aagagtgagg ggtctgtcca tggggtggca gtgatttcac     2940

acccgccttt cttgaatggc ttcgtgttac tcagccgtgc cctggcagga atggaactcc     3000

atcagggaac agggcagctc tgtttgaatg gggtgaaaaa cagcaaaatt aattcttagc     3060

aagctccttg ttctctactg ttcaccggga cctggctggc aaatgactta gctattagta     3120

tatttaaaaa ctgttcaaaa gcaaaagaga aggaacagga atgaaaggaa accttccctt     3180

aactctttct gcttcccata gcaggtctgg ttcctgctcc ccgcctagga caggagctgt     3240

ctggagctcc acctttgcaa agaaaggaaa aacacaaatt gcccccagat tggcccagtg     3300

gcatgccatt aggtgatttt gcataggggc catatcattc atggccaaaa aaaaccaaaa     3360

agcaaaaaac aaaaacaagt cccatgtcct actgactcta gttcttccag tcgttatcct     3420

ctgctgtctc tctggcatcc tatgaatcag atcaagccca tgctgttgtt ggtttttaag     3480

gtttctttca ataataggct aaggaaagac atgtttttct cttttaaatc tctgcaactc     3540

caaagtagac tccttcgaac gtatttaatt tggccttttc agctttcttc ttgcccagct     3600

ctgtcgaatt catgggtgtg tgtgcacatg ttggtttcac tcacccagag taattttgtg     3660

agcatgcatg tgctttttaa tttctgcttg aatgtttgtc ctgctgtgtt gcagcttcta     3720

aagacattgt caccgagtgt gtgtgactca aagatcaaga gtgaggctaa actgcgaccc     3780

caacatcact tccttcatgg aaaggtgttg gcgctgatgt agctcatgga aggatcagac     3840

tgggaaccac agaggaagga tgaggtggga tgtggaggtc agagcatctc acgagagtcc     3900

ctcaggctct gcaacactag attcgaatat gagcctaggg tttccccaac acgtgcgtgc     3960

atatgaaacc acatcatgat tcccgacgtg agttagatga gggagagttt gtgtaactcc     4020

acacccagga gggtaagcca ctttattatc atgctttggg gctgtgctta agaatttaag     4080

ctctgtttta aagccgaaga agaaaacatt tgaatttacc ttcatatgcc actaagaaca     4140

aaagctctga agttcttcct gctggcacca aatattagga ttacaagctg tctctctgac     4200

accagtggta aaaaagcaag tagaatagtt tctgagtctg tgttgcagcc tctgacacgt     4260

ggctcaccgc tgtcatttgg gggatggaat gaacagtcac tgttctatag catcctcctg     4320

tgctcttacc taaggaatct aaattgtcct agccttccat tgctatgcac tgaatgagga     4380

ctactctcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg     4440

gatctactaa catgtttagc aaatggctct gacagggtgg ccatgagcag atgagaccag     4500

ctcttgcttg gttggaagcc acactgcagt ttgcagttta gcctttggtg tctcagtggc     4560

ttcttgctta ttccatgctt tttctatccc atcctctctc tgtgccctcc tgcaatggca     4620

gccttggcac aatgcctggg tgtcctcatc cttgctttac tctggaaagt gtggggatgg     4680

agaggatggt gcatttccag tgcttcctta cctgtcaata acaatggtgg ccacctgggt     4740

cccagcactt ggctggtgga gagatttttt tcattatgga gctaataaag ggtccctacg     4800

ttttacattg attaatgaat tatcacccag acatgtgcag atgaaatgtc aatataagaa     4860

aaatcaaggt atttgggaaa catgggcata atcaggtagt tttgctaaaa ttcctcttcc     4920

ttggtctaca taaagaagac atgggtctgt catagaatgg ggacattaga ctgaaaactg     4980

ggacaacccc cttccttatt ttatagagac taggagttaa ggggcctgcc taagattgca     5040

gtgataaaga actgaaccct aaatcagctc ccactaatga aaccctgctt tccttgtatc     5100

ttttaaactc agttctgcat ccaacttgag aagaaaaaaa gcttctttcc atatcaagta     5160

ccatatgagt tcatttaaac tgcaccttgc agaaatgcat tgccagaaag caccagtagc     5220

ctcctatctg caagcagagt agtgctctgc tctggggagg ggtcattgga aaccataatg     5280

cagagtgggc cccctactcc atttcccagc aaaaggctcc agctggaggg atgggttgtg     5340

gggcaacctg gttcctgcta actgccagat tgaatgtgtg ggctagaatg cctgcacatt     5400

tagttaaact gggctcagca tgcttgtcct caaaatgtcc atcctggtca cagcacacaa     5460

gatggctatt ggtctgcttt taccctaccc tgtactatac atgaaaattc cagttattaa     5520

cacactcaaa ctggtggagc ttgttcaccc taggaagggg attgtatata tggcaggctt     5580

ccctggtgcc gatgtaaagg gctacatttg ggaacatttg acttccttgg gactcttaag     5640

tgcataatga tggcatgaag taaaaggggc ctcaatgatg ataggaaaat cagttctttt     5700

aaaatttctt caagaaaatc caggctatca catagtcttt ctgtgtgact tattaggaga     5760

taggaagagc attgggaaac ttgcacagct agctatgcat ctacattttg gtttggggtt     5820

agttatgaaa tgttcttaat atgacgtgtt caataacttc acataaactt cctgttctcc     5880

aaaacctcaa agagatagag ttaatgagtt gttgtttttt tttaaatggg ggtagttttc     5940

tatctgtcat gggctctagc atctactccg ctacccaatt ctgtcatctc caagctgagt     6000

ttcctcttct gaggcagagg ctggagcagt tctttttcag ttctcatcct ctccatccca     6060

atccagtata tcaatcaact ctaactcgga gacgtctagc tggcaatgtt tctaaaactt     6120

tcactggatt tctttagaca ttgaagcaaa catttttttc taagaattgc ttctcagatg     6180

atgatatcaa atgtatatgc ttttgcaagt ttgaaaagtt caaattaacc acttttgact     6240

aggtaagtct ttctaaaaac catttaaagc taactgggtc ttagcatcct cctgtgtatg     6300

gaagagacag gtgaccgctc caggttgggt gctcacagaa cccttttcct gactctcatg     6360

gaagatggtg gaaggaaaat agactgtctc atcaaccctc ctgtgtcctc tgaagcaatc     6420

tcagttttta ttaaccacct cttctgtgtt tctggtagct atttaacctg tatttaatct     6480

gtacttccta tgccagcctc aattttattt gatttttaca attattctct tctaaccaat     6540

gaagtgtttg tcagtatgcc ccaaagcttg ctcttttgtg ctcccttttg aataactttc     6600

tatccagaaa aagagattat ttgggacttg agatttgcag tgataccaac ttatagcaat     6660

gatgtacttt aagggaacta cccaactatg ttgtgataga agaaagagaa accttcactt     6720

tggcattttt ttttaatcac tgtttatttt tctgtttgcg gcccaggaag cagtgggagg     6780

tggtggcaga tatgctttgc atatggattg ttatgttttt atttgggcaa gtttaatcat     6840

ggaaaactca aaaagaaggg gggaaatggt cagtttaagc caaaagaaac tttctaaaca     6900

atgtataggt acacagcaaa attaaacaaa tccaacaatt tctgaagctt agtgtaattg     6960

agtggtggtt gttattcaat aaaattattc ccaaaagtgt ttctcctaag agtgcagttc     7020

ccatgagtca cttcctgaac ccattgacca aaggtggaca gagacaatcc tgtagacctt     7080

gacattcaga aagatgtgag ctgcttactg atcatatatg catacgtttc tttacagcag     7140

aggaaaccat tgtccacaaa actgatgttc ttttggggtt ttatgtacag acttgtccaa     7200

tcatgtgtgt ggttcctgcg agttgctgat gactccgcat tgaagctctc tgagttcttt     7260

gattttaagt tgggtttatg gaattttttc aaatgttgga aggtgtgtgg ttcttcctgc     7320

cctccctccc cttttggaaa tatgaaagca aatgtttaga agaattcctt ttgaaaagct     7380

gtgtcgtgtt ccctgtgaaa ctgagcaggt gtgtgttggc gcgctaagtg ccacatgctt     7440

gtgtgtagag gaggaggtgg ccctgccggc tccgcgctgc tgtgcctgtg atccctacct     7500

gctccccgct cctgttgcca gcagcactca ctgcactcct ttgtcatata ctctgcatca     7560

ctgtcatact cacaacttcg tgaataaagt tgtgtgcttt attcgt                    7606


<210> 1694
<211> 1747
<212> DNA
<213> Homo sapiens

<400> 1694
gcacaaacca tcgcactttg gccatagcag gtgacaaaca ttaccacccc agctgtgcac       60

gatgcagcag atgcaaccag atgttcacag aaggagagga aatgtatctt caaggctcca      120

ccgtttggca tcccgactgt aagcaatcta cgaagaccga ggaaaagctg cggctgccaa      180

acattcggcg ttcttcatcc gatttctttt attccaaaag tctgattcga cgcacaggac      240

ggtctccgtc tctgcagcct accaggacat cctcggaaag tatttattct aggccaggct      300

ccagtattcc tggctcacca ggtcatacta tctatgcaaa agtagacaat gagatcctgg      360

attacaagga tttagcagcc attccgaagg tcaaggcaat ttatgacatt gaacgtccag      420

atcttattac ctatgagcct ttctacactt cgggctatga tgacaaacag gagagacaga      480

gccttggaga gtctccgagg actttgtctc ctactccatc agcagaaggg taccaggatg      540

ttcgggatcg gatgatccat cggtccacga gccagggctc catcaactcc cctgtgtaca      600

gccgccacag ctacactcca accacgtccc gctctcccca gcatttccac agacctgagc      660

ttttgtctcc tggtgtgcag aggttgtcgt acctgcgcac cagcagcctc agccccaccc      720

acagcgactc ccgccccaac ccccctttcc gacaccactt cattccccat atcaaaggca      780

atgagccgtc cagcggccgg aactcccctc tcccttaccg gccagacagc cgccctctaa      840

ctccaactta cgctcaggcc cctaaacatt tccatgttcc agatcaagga atcaacattt      900

accgaaagcc acccatctac aaacagcatg ctgccttggc agcccagagc aagtcctcag      960

aagatatcat caagttttcc aagttcccag cagcccaggc accagacccc agcgagacac     1020

caaagattga gacggaccac tggcctggtc ccccctcatt tgctgtcgta ggacctgaca     1080

tgaaacgcag atctagtggc agagaggaag atgatgagga acttctgaga cgtcggcagc     1140

ttcaagaaga gcaattaatg aagcttaact caggcctggg acagttgatc ttgaaagaag     1200

agatggagaa agagagccgg gaaaggtcat ctctgttagc cagtcgctac gattctccca     1260

tcaactcagc ttcacatatt ccatcatcta aaactgcatc tctccctggc tatggaagaa     1320

atgggcttca ccggcctgtt tctaccgact tcgctcagta taacagctat ggggatgtca     1380

gcgggggagt gcgagattac cagacactcc cagatggcca catgcctgca atgagaatgg     1440

accgaggagt gtctatgccc aacatgttgg aaccaaagat atttccatat gaaatgctca     1500

tggtgaccaa cagagggcga aacaaaatcc tcagagaggt ggacagaacc aggctggagc     1560

gccacttagc ccctgaagtg tttcgggaaa tctttggaat gtccatacag gagtttgaca     1620

ggttacctct ttggagacgc aacgacatga agaaaaaagc aaaactcttc taagtcccac     1680

tcgtgaatgg caattagaga aaggactgac agtggcggtg ccccatagga tgtcatattg     1740

aggccca                                                               1747


<210> 1695
<211> 3983
<212> DNA
<213> Homo sapiens

<400> 1695
gcttccactc ccagagttta ttcctcgttc cttcttcagt cctgctcgtc ggaggacccg       60

gttgccatgg tgaaggaaaa agtggcccac cctcaggacc ctcaccaccc atcagagaag      120

cctgtcattc actgccataa atgtggggag ccttgcaagg gtgaagtgct tcgggtccag      180

accaaacatt tccacatcaa gtgtttcacc tgcaaagtgt gtggctgtga cctggcacaa      240

gggggcttct tcataaagaa cggagagtat ctctgcaccc tggactacca gcggatgtac      300

gggacacgct gccatggctg tggggagttc gtggagggcg aagtggtgac tgctctgggc      360

aagacctacc atcccaattg ctttgcttgt actatctgca agcgcccgtt tccacccgga      420

gaccgagtca cattcaatgg gagagactgc ctttgtcaac tctgtgcaca gccgatgtcg      480

tccagtccga aagaaaccac cttctccagc aattgtgccg gctgcggaag agatatcaag      540

aatgggcagg cgctgctggc gctggataag cagtggcact tggggtgctt taaatgcaag      600

tcctgcggga aggtcctcac cggggagtac atcagcaagg atggtgctcc gtactgtgaa      660

aaggactacc agggactctt tggggtgaaa tgtgaggcgt gtcaccagtt tatcacaggg      720

aaagtcctgg aggcaggtga caaacattac caccccagct gtgcacgatg cagcagatgc      780

aaccagatgt tcacagaagg agaggaaatg tatcttcaag gctccaccgt ttggcatccc      840

gactgtaagc aatctacgaa gaccgaggaa aagctgcggc ctaccaggac atcctcggaa      900

agtatttatt ctaggccagg ctccagtatt cctggctcac caggtcatac tatctatgca      960

aaagtagaca atgagatcct ggattacaag gatttagcag ccattccgaa ggtcaaggca     1020

atttatgaca ttgaacgtcc agatcttatt acctatgagc ctttctacac ttcgggctat     1080

gatgacaaac aggagagaca gagccttgga gagtctccga ggactttgtc tcctactcca     1140

tcagcagaag ggtaccagga tgttcgggat cggatgatcc atcggtccac gagccagggc     1200

tccatcaact cccctgtgta cagccgccac agctacactc caaccacgtc ccgctctccc     1260

cagcatttcc acagacctgg caatgagccg tccagcggcc ggaactcccc tctcccttac     1320

cggccagaca gccgccctct aactccaact tacgctcagg cccctaaaca tttccatgtt     1380

ccagatcaag gaatcaacat ttaccgaaag ccacccatct acaaacagca tgctgccttg     1440

gcagcccaga gcaagtcctc agaagatatc atcaagtttt ccaagttccc agcagcccag     1500

gcaccagacc ccagcgagac accaaagatt gagacggacc actggcctgg tcccccctca     1560

tttgctgtcg taggacctga catgaaacgc agatctagtg gcagagagga agatgatgag     1620

gaacttctga gacgtcggca gcttcaagaa gagcaattaa tgaagcttaa ctcaggcctg     1680

ggacagttga tcttgaaaga agagatggag aaagagagcc gggaaaggtc atctctgtta     1740

gccagtcgct acgattctcc catcaactca gcttcacata ttccatcatc taaaactgca     1800

tctctccctg gctatggaag aaatgggctt caccggcctg tttctaccga cttcgctcag     1860

tataacagct atggggatgt cagcggggga gtgcgagatt accagacact cccagatggc     1920

cacatgcctg caatgagaat ggaccgagga gtgtctatgc ccaacatgtt ggaaccaaag     1980

atatttccat atgaaatgct catggtgacc aacagagggc gaaacaaaat cctcagagag     2040

gtggacagaa ccaggctgga gcgccactta gcccctgaag tgtttcggga aatctttgga     2100

atgtccatac aggagtttga caggttacct ctttggagac gcaacgacat gaagaaaaaa     2160

gcaaaactct tctaagtccc actcgtgaat ggcaattaga gaaaggactg acagtggcgg     2220

tgccccatag gatgtcatat tgaggcccaa acttgattgg agaatttgca aactaccgtc     2280

gctcagcaac accaaaaaga gaaagtctgg ttaaaacacc atgagtcaaa tgtcgggcca     2340

gccaacagta acacttgcca agaagcatgg cgtagaaatt tctatgttcc gaaacacaga     2400

gtagtgtcca catgtgagct tttcacatta ccttatgtat acaacaggag ctgcgttgtt     2460

ttcttctttt tcttttcctt tatctgttgt ccaacaacag tgctgactgt ccggataaga     2520

gctggcaagt gcccttagga tgccgcatgg gaaaaatcgg ttatcataat ttcaaagtat     2580

aaatatattt attaagtagc gctgcggcta agaaggaaga gtgaggggtc tgtccatggg     2640

gtggcagtga tttcacaccc gcctttcttg aatggcttcg tgttactcag ccgtgccctg     2700

gcaggaatgg aactccatca gggaacaggg cagctctgtt tgaatggggt gaaaaacagc     2760

aaaattaatt cttagcaagc tccttgttct ctactgttca ccgggacctg gctggcaaat     2820

gacttagcta ttagtatatt taaaaactgt tcaaaagcaa aagagaagga acaggaatga     2880

aaggaaacct tcccttaact ctttctgctt cccatagcag gtctggttcc tgctccccgc     2940

ctaggacagg agctgtctgg agctccacct ttgcaaagaa aggaaaaaca caaattgccc     3000

ccagattggc ccagtggcat gccattaggt gattttgcat aggggccata tcattcatgg     3060

ccaaaaaaaa ccaaaaagca aaaaacaaaa acaagtccca tgtcctactg actctagttc     3120

ttccagtcgt tatcctctgc tgtctctctg gcatcctatg aatcagatca agcccatgct     3180

gttgttggtt tttaaggttt ctttcaataa taggctaagg aaagacatgt ttttctcttt     3240

taaatctctg caactccaaa gtagactcct tcgaacgtat ttaatttggc cttttcagct     3300

ttcttcttgc ccagctctgt cgaattcatg ggtgtgtgtg cacatgttgg tttcactcac     3360

ccagagtaat tttgtgagca tgcatgtgct ttttaatttc tgcttgaatg tttgtcctgc     3420

tgtgttgcag cttctaaaga cattgtcacc gagtgtgtgt gactcaaaga tcaagagtga     3480

ggctaaactg cgaccccaac atcacttcct tcatggaaag gtgttggcgc tgatgtagct     3540

catggaagga tcagactggg aaccacagag gaaggatgag gtgggatgtg gaggtcagag     3600

catctcacga gagtccctca ggctctgcaa cactagattc gaatatgagc ctagggtttc     3660

cccaacacgt gcgtgcatat gaaaccacat catgattccc gacgtgagtt agatgaggga     3720

gagtttgtgt aactccacac ccaggagggt aagccacttt attatcatgc tttggggctg     3780

tgcttaagaa tttaagctct gttttaaagc cgaagaagaa aacatttgaa tttaccttca     3840

tatgccacta agaacaaaag ctctgaagtt cttcctgctg gcaccaaata ttaggattac     3900

aagctgtctc tctgacacca gtggtaaaaa agcaagtaga atagtttctg agtctgtgtt     3960

gcagcctctg acacgtggct cac                                             3983


<210> 1696
<211> 6583
<212> DNA
<213> Homo sapiens

<400> 1696
cgagcttcgg agagaagcct gatatgtaac ccaggcaggt gggagcctca gtctgtcggg       60

ctgaggtctg gcatctacaa agcctcttgg ccgtgttctg aacttgaagc ctggaggagt      120

tctctgctca gcacagccaa ggaacagaat tagaagaaaa ggaaccctgg cctgaggcag      180

gtgacaaaca ttaccacccc agctgtgcac gatgcagcag atgcaaccag atgttcacag      240

aaggagagga aatgtatctt caaggctcca ccgtttggca tcccgactgt aagcaatcta      300

cgaagaccga ggaaaagctg cgggcaaaag tagacaatga gatcctggat tacaaggatt      360

tagcagccat tccgaaggtc aaggcaattt atgacattga acgtccagat cttattacct      420

atgagccttt ctacacttcg ggctatgatg acaaacagga gagacagagc cttggagagt      480

ctccgaggac tttgtctcct actccatcag cagaagggta ccaggatgtt cgggatcgga      540

tgatccatcg gtccacgagc cagggctcca tcaactcccc tgtgtacagc cgccacagct      600

acactccaac cacgtcccgc tctccccagc atttccacag acctgatcaa ggaatcaaca      660

tttaccgaaa gccacccatc tacaaacagc atgctgcctt ggcagcccag agcaagtcct      720

cagaagatat catcaagttt tccaagttcc cagcagccca ggcaccagac cccagcgaga      780

caccaaagat tgagacggac cactggcctg gtcccccctc atttgctgtc gtaggacctg      840

acatgaaacg cagatctagt ggcagagagg aagatgatga ggaacttctg agacgtcggc      900

agcttcaaga agagcaatta atgaagctta actcaggcct gggacagttg atcttgaaag      960

aagagatgga gaaagagagc cgggaaaggt catctctgtt agccagtcgc tacgattctc     1020

ccatcaactc agcttcacat attccatcat ctaaaactgc atctctccct ggctatggaa     1080

gaaatgggct tcaccggcct gtttctaccg acttcgctca gtataacagc tatggggatg     1140

tcagcggggg agtgcgagat taccagacac tcccagatgg ccacatgcct gcaatgagaa     1200

tggaccgagg agtgtctatg cccaacatgt tggaaccaaa gatatttcca tatgaaatgc     1260

tcatggtgac caacagaggg cgaaacaaaa tcctcagaga ggtggacaga accaggctgg     1320

agcgccactt agcccctgaa gtgtttcggg aaatctttgg aatgtccata caggagtttg     1380

acaggttacc tctttggaga cgcaacgaca tgaagaaaaa agcaaaactc ttctaagtcc     1440

cactcgtgaa tggcaattag agaaaggact gacagtggcg gtgccccata ggatgtcata     1500

ttgaggccca aacttgattg gagaatttgc aaactaccgt cgctcagcaa caccaaaaag     1560

agaaagtctg gttaaaacac catgagtcaa atgtcgggcc agccaacagt aacacttgcc     1620

aagaagcatg gcgtagaaat ttctatgttc cgaaacacag agtagtgtcc acatgtgagc     1680

ttttcacatt accttatgta tacaacagga gctgcgttgt tttcttcttt ttcttttcct     1740

ttatctgttg tccaacaaca gtgctgactg tccggataag agctggcaag tgcccttagg     1800

atgccgcatg ggaaaaatcg gttatcataa tttcaaagta taaatatatt tattaagtag     1860

cgctgcggct aagaaggaag agtgaggggt ctgtccatgg ggtggcagtg atttcacacc     1920

cgcctttctt gaatggcttc gtgttactca gccgtgccct ggcaggaatg gaactccatc     1980

agggaacagg gcagctctgt ttgaatgggg tgaaaaacag caaaattaat tcttagcaag     2040

ctccttgttc tctactgttc accgggacct ggctggcaaa tgacttagct attagtatat     2100

ttaaaaactg ttcaaaagca aaagagaagg aacaggaatg aaaggaaacc ttcccttaac     2160

tctttctgct tcccatagca ggtctggttc ctgctccccg cctaggacag gagctgtctg     2220

gagctccacc tttgcaaaga aaggaaaaac acaaattgcc cccagattgg cccagtggca     2280

tgccattagg tgattttgca taggggccat atcattcatg gccaaaaaaa accaaaaagc     2340

aaaaaacaaa aacaagtccc atgtcctact gactctagtt cttccagtcg ttatcctctg     2400

ctgtctctct ggcatcctat gaatcagatc aagcccatgc tgttgttggt ttttaaggtt     2460

tctttcaata ataggctaag gaaagacatg tttttctctt ttaaatctct gcaactccaa     2520

agtagactcc ttcgaacgta tttaatttgg ccttttcagc tttcttcttg cccagctctg     2580

tcgaattcat gggtgtgtgt gcacatgttg gtttcactca cccagagtaa ttttgtgagc     2640

atgcatgtgc tttttaattt ctgcttgaat gtttgtcctg ctgtgttgca gcttctaaag     2700

acattgtcac cgagtgtgtg tgactcaaag atcaagagtg aggctaaact gcgaccccaa     2760

catcacttcc ttcatggaaa ggtgttggcg ctgatgtagc tcatggaagg atcagactgg     2820

gaaccacaga ggaaggatga ggtgggatgt ggaggtcaga gcatctcacg agagtccctc     2880

aggctctgca acactagatt cgaatatgag cctagggttt ccccaacacg tgcgtgcata     2940

tgaaaccaca tcatgattcc cgacgtgagt tagatgaggg agagtttgtg taactccaca     3000

cccaggaggg taagccactt tattatcatg ctttggggct gtgcttaaga atttaagctc     3060

tgttttaaag ccgaagaaga aaacatttga atttaccttc atatgccact aagaacaaaa     3120

gctctgaagt tcttcctgct ggcaccaaat attaggatta caagctgtct ctctgacacc     3180

agtggtaaaa aagcaagtag aatagtttct gagtctgtgt tgcagcctct gacacgtggc     3240

tcaccgctgt catttggggg atggaatgaa cagtcactgt tctatagcat cctcctgtgc     3300

tcttacctaa ggaatctaaa ttgtcctagc cttccattgc tatgcactga atgaggacta     3360

ctctcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttggat     3420

ctactaacat gtttagcaaa tggctctgac agggtggcca tgagcagatg agaccagctc     3480

ttgcttggtt ggaagccaca ctgcagtttg cagtttagcc tttggtgtct cagtggcttc     3540

ttgcttattc catgcttttt ctatcccatc ctctctctgt gccctcctgc aatggcagcc     3600

ttggcacaat gcctgggtgt cctcatcctt gctttactct ggaaagtgtg gggatggaga     3660

ggatggtgca tttccagtgc ttccttacct gtcaataaca atggtggcca cctgggtccc     3720

agcacttggc tggtggagag atttttttca ttatggagct aataaagggt ccctacgttt     3780

tacattgatt aatgaattat cacccagaca tgtgcagatg aaatgtcaat ataagaaaaa     3840

tcaaggtatt tgggaaacat gggcataatc aggtagtttt gctaaaattc ctcttccttg     3900

gtctacataa agaagacatg ggtctgtcat agaatgggga cattagactg aaaactggga     3960

caaccccctt ccttatttta tagagactag gagttaaggg gcctgcctaa gattgcagtg     4020

ataaagaact gaaccctaaa tcagctccca ctaatgaaac cctgctttcc ttgtatcttt     4080

taaactcagt tctgcatcca acttgagaag aaaaaaagct tctttccata tcaagtacca     4140

tatgagttca tttaaactgc accttgcaga aatgcattgc cagaaagcac cagtagcctc     4200

ctatctgcaa gcagagtagt gctctgctct ggggaggggt cattggaaac cataatgcag     4260

agtgggcccc ctactccatt tcccagcaaa aggctccagc tggagggatg ggttgtgggg     4320

caacctggtt cctgctaact gccagattga atgtgtgggc tagaatgcct gcacatttag     4380

ttaaactggg ctcagcatgc ttgtcctcaa aatgtccatc ctggtcacag cacacaagat     4440

ggctattggt ctgcttttac cctaccctgt actatacatg aaaattccag ttattaacac     4500

actcaaactg gtggagcttg ttcaccctag gaaggggatt gtatatatgg caggcttccc     4560

tggtgccgat gtaaagggct acatttggga acatttgact tccttgggac tcttaagtgc     4620

ataatgatgg catgaagtaa aaggggcctc aatgatgata ggaaaatcag ttcttttaaa     4680

atttcttcaa gaaaatccag gctatcacat agtctttctg tgtgacttat taggagatag     4740

gaagagcatt gggaaacttg cacagctagc tatgcatcta cattttggtt tggggttagt     4800

tatgaaatgt tcttaatatg acgtgttcaa taacttcaca taaacttcct gttctccaaa     4860

acctcaaaga gatagagtta atgagttgtt gttttttttt aaatgggggt agttttctat     4920

ctgtcatggg ctctagcatc tactccgcta cccaattctg tcatctccaa gctgagtttc     4980

ctcttctgag gcagaggctg gagcagttct ttttcagttc tcatcctctc catcccaatc     5040

cagtatatca atcaactcta actcggagac gtctagctgg caatgtttct aaaactttca     5100

ctggatttct ttagacattg aagcaaacat ttttttctaa gaattgcttc tcagatgatg     5160

atatcaaatg tatatgcttt tgcaagtttg aaaagttcaa attaaccact tttgactagg     5220

taagtctttc taaaaaccat ttaaagctaa ctgggtctta gcatcctcct gtgtatggaa     5280

gagacaggtg accgctccag gttgggtgct cacagaaccc ttttcctgac tctcatggaa     5340

gatggtggaa ggaaaataga ctgtctcatc aaccctcctg tgtcctctga agcaatctca     5400

gtttttatta accacctctt ctgtgtttct ggtagctatt taacctgtat ttaatctgta     5460

cttcctatgc cagcctcaat tttatttgat ttttacaatt attctcttct aaccaatgaa     5520

gtgtttgtca gtatgcccca aagcttgctc ttttgtgctc ccttttgaat aactttctat     5580

ccagaaaaag agattatttg ggacttgaga tttgcagtga taccaactta tagcaatgat     5640

gtactttaag ggaactaccc aactatgttg tgatagaaga aagagaaacc ttcactttgg     5700

catttttttt taatcactgt ttatttttct gtttgcggcc caggaagcag tgggaggtgg     5760

tggcagatat gctttgcata tggattgtta tgtttttatt tgggcaagtt taatcatgga     5820

aaactcaaaa agaagggggg aaatggtcag tttaagccaa aagaaacttt ctaaacaatg     5880

tataggtaca cagcaaaatt aaacaaatcc aacaatttct gaagcttagt gtaattgagt     5940

ggtggttgtt attcaataaa attattccca aaagtgtttc tcctaagagt gcagttccca     6000

tgagtcactt cctgaaccca ttgaccaaag gtggacagag acaatcctgt agaccttgac     6060

attcagaaag atgtgagctg cttactgatc atatatgcat acgtttcttt acagcagagg     6120

aaaccattgt ccacaaaact gatgttcttt tggggtttta tgtacagact tgtccaatca     6180

tgtgtgtggt tcctgcgagt tgctgatgac tccgcattga agctctctga gttctttgat     6240

tttaagttgg gtttatggaa ttttttcaaa tgttggaagg tgtgtggttc ttcctgccct     6300

ccctcccctt ttggaaatat gaaagcaaat gtttagaaga attccttttg aaaagctgtg     6360

tcgtgttccc tgtgaaactg agcaggtgtg tgttggcgcg ctaagtgcca catgcttgtg     6420

tgtagaggag gaggtggccc tgccggctcc gcgctgctgt gcctgtgatc cctacctgct     6480

ccccgctcct gttgccagca gcactcactg cactcctttg tcatatactc tgcatcactg     6540

tcatactcac aacttcgtga ataaagttgt gtgctttatt cgt                       6583


<210> 1697
<211> 2803
<212> DNA
<213> Homo sapiens

<400> 1697
gcaatcattt atcagactgt gggagggggc cagcgttcgg gagcttttca tagcccgtcc       60

tcggtgcgag gaatacaagg tggtgtcagt gaccagagat taggacagta gaattttgca      120

tttgttacag cagcagctgt agcgagtggt ttcagccgca gggcagagtc cccgagctgg      180

gcgcggctgc agctcggcgg gcgggcggag aagagcgcgg gggcgatagc ggggcgggca      240

tgggagcggg gcccgccgag gcggggcggg actcgagacc acagccccgg acctcacaag      300

cggatgccgg ggcttctcct ggctgcccca gcgcccgcgg atctgtctgc cgaggcgcgc      360

ttccactccc agagtttatt cctcgttcct tcttcagtcc tgctcgtcgg aggacccggt      420

tgccatggtg aaggaaaaag tggcccaccc tcaggaccct caccacccat cagagaagcc      480

tgtcattcac tgccataaat gtggggagcc ttgcaagggt gaagtgcttc gggtccagac      540

caaacatttc cacatcaagt gtttcacctg caaagtgtgt ggctgtgacc tggcacaagg      600

gggcttcttc ataaagaacg gagagtatct ctgcaccctg gactaccagc ggatgtacgg      660

gacacgctgc catggctgtg gggagttcgt ggagggcgaa gtggtgactg ctctgggcaa      720

gacctaccat cccaattgct ttgcttgtac tatctgcaag cgcccgtttc cacccggaga      780

ccgagtcaca ttcaatggga gagactgcct ttgtcaactc tgtgcacagc cgatgtcgtc      840

cagtccgaaa gaaaccacct tctccagcaa ttgtgccggc tgcggaagag atatcaagaa      900

tgggcaggcg ctgctggcgc tggataagca gtggcacttg gggtgcttta aatgcaagtc      960

ctgcgggaag gtcctcaccg gggagtacat cagcaaggat ggtgctccgt actgtgaaaa     1020

ggactaccag ggactctttg gggtgaaatg tgaggcgtgt caccagttta tcacagggaa     1080

agtcctggag gcaggtgaca aacattacca ccccagctgt gcacgatgca gcagatgcaa     1140

ccagatgttc acagaaggag aggaaatgta tcttcaaggc tccaccgttt ggcatcccga     1200

ctgtaagcaa tctacgaaga ccgaggaaaa gctgcggcct accaggacat cctcggaaag     1260

tatttattct aggccaggct ccagtattcc tggctcacca ggtcatacta tctatgcaaa     1320

agtagacaat gagatcctgg attacaagga tttagcagcc attccgaagg tcaaggcaat     1380

ttatgacatt gaacgtccag atcttattac ctatgagcct ttctacactt cgggctatga     1440

tgacaaacag gagagacaga gccttggaga gtctccgagg actttgtctc ctactccatc     1500

agcagaaggg taccaggatg ttcgggatcg gatgatccat cggtccacga gccagggctc     1560

catcaactcc cctgtgtaca gccgccacag ctacactcca accacgtccc gctctcccca     1620

gcatttccac agacctggca atgagccgtc cagcggccgg aactcccctc tcccttaccg     1680

gccagacagc cgccctctaa ctccaactta cgctcaggcc cctaaacatt tccatgttcc     1740

agatcaagga atcaacattt accgaaagcc acccatctac aaacagcatg gacctgacat     1800

gaaacgcaga tctagtggca gagaggaaga tgatgaggaa cttctgagac gtcggcagct     1860

tcaagaagag caattaatga agcttaactc aggcctggga cagttgatct tgaaagaaga     1920

gatggagaaa gagagccggg aaaggtcatc tctgttagcc agtcgctacg attctcccat     1980

caactcagct tcacatattc catcatctaa aactgcatct ctccctggct atggaagaaa     2040

tgggcttcac cggcctgttt ctaccgactt cgctcagtat aacagctatg gggatgtcag     2100

cgggggagtg cgagatttcc agacactccc agatggccac atgcctgcaa tgagaatgga     2160

ccgaggagtg tctatgccca acatgttgga accaaagata tttccatatg aaatgctcat     2220

ggtgaccaac agagggcgaa acaaaatcct cagagaggtg gacagaacca ggctggagcg     2280

ccacttagcc cctgaagtgt ttcgggaaat ctttggaatg tccatacagg agtttgacag     2340

gttacctctt tggagacgca acgacatgaa gaaaaaagca aaactcttct aagtcccact     2400

cgtgaatggc aattagagaa aggactgaca gtggcggtgc cccataggat gtcatattga     2460

ggcccaaact tgattggaga atttgcaaac taccgtcgct cagcaacacc aaaaagagaa     2520

agtctggtta aaacaccatg agtcaaatgt cgggccagcc aacagtaaca cttgccaaga     2580

agcatggcgt agaaatttct atgttccgaa acacagagta gtgtccacat gtgagctttt     2640

cacattacct tatgtataca acaggagctg cgttgttttc ttctttttct tttcctttat     2700

ctgttgtcca acaacagtgc tgactgtccg gataagagct ggcaagtgcc cttaggatgc     2760

cgcatgggaa aaatcggtta tcataatttc aaagtataaa tat                       2803


<210> 1698
<211> 7688
<212> DNA
<213> Homo sapiens

<400> 1698
atgcctgcct tccttggtct aaagtgtctg gggaaattgt gcagctctga gaaaagcaaa       60

gtcacctcat ctgagagaac cagtgccagg ggctcgaaca gaaagagact gattgttgag      120

gaccggaggg tctctgggac ctccttcacc gctcataggc gtgccactat cactcatttg      180

ctgtatctct gtcccaagga ctactgccca cgtgggcgtg tatgtaacag cgttgatcct      240

tttgtggccc accctcagga ccctcaccac ccatcagaga agcctgtcat tcactgccat      300

aaatgtgggg agccttgcaa gggtgaagtg cttcgggtcc agaccaaaca tttccacatc      360

aagtgtttca cctgcaaagt gtgtggctgt gacctggcac aagggggctt cttcataaag      420

aacggagagt atctctgcac cctggactac cagcggatgt acgggacacg ctgccatggc      480

tgtggggagt tcgtggaggg cgaagtggtg actgctctgg gcaagaccta ccatcccaat      540

tgctttgctt gtactatctg caagcgcccg tttccacccg gagaccgagt cacattcaat      600

gggagagact gcctttgtca actctgtgca cagccgatgt cgtccagtcc gaaagaaacc      660

accttctcca gcaattgtgc cggctgcgga agagatatca agaatgggca ggcgctgctg      720

gcgctggata agcagtggca cttggggtgc tttaaatgca agtcctgcgg gaaggtcctc      780

accggggagt acatcagcaa ggatggtgct ccgtactgtg aaaaggacta ccagggactc      840

tttggggtga aatgtgaggc gtgtcaccag tttatcacag ggaaagtcct ggaggcaggt      900

gacaaacatt accaccccag ctgtgcacga tgcagcagat gcaaccagat gttcacagaa      960

ggagaggaaa tgtatcttca aggctccacc gtttggcatc ccgactgtaa gcaatctacg     1020

aagaccgagg aaaagctgcg gctgccaaac attcggcgtt cttcatccga tttcttttat     1080

tccaaaagtc tgattcgacg cacaggacgg tctccgtctc tgcagcctac caggacatcc     1140

tcggaaagta tttattctag gccaggctcc agtattcctg gctcaccagg tcatactatc     1200

tatgcaaaag tagacaatga gatcctggat tacaaggatt tagcagccat tccgaaggtc     1260

aaggcaattt atgacattga acgtccagat cttattacct atgagccttt ctacacttcg     1320

ggctatgatg acaaacagga gagacagagc cttggagagt ctccgaggac tttgtctcct     1380

actccatcag cagaagggta ccaggatgtt cgggatcgga tgatccatcg gtccacgagc     1440

cagggctcca tcaactcccc tgtgtacagc cgccacagct acactccaac cacgtcccgc     1500

tctccccagc atttccacag acctgagctt ttgtctcctg gtgtgcagag gttgtcgtac     1560

ctgcgcacca gcagcctcag ccccacccac agcgactccc gccccaaccc ccctttccga     1620

caccacttca ttccccatat caaaggcaat gagccgtcca gcggccggaa ctcccctctc     1680

ccttaccggc cagacagccg ccctctaact ccaacttacg ctcaggcccc taaacatttc     1740

catgttccag atcaaggaat caacatttac cgaaagccac ccatctacaa acagcatgct     1800

gccttggcag cccagagcaa gtcctcagaa gatatcatca agttttccaa gttcccagca     1860

gcccaggcac cagaccccag cgagacacca aagattgaga cggaccactg gcctggtccc     1920

ccctcatttg ctgtcgtagg acctgacatg aaacgcagat ctagtggcag agaggaagat     1980

gatgaggaac ttctgagacg tcggcagctt caagaagagc aattaatgaa gcttaactca     2040

ggcctgggac agttgatctt gaaagaagag atggagaaag agagccggga aaggtcatct     2100

ctgttagcca gtcgctacga ttctcccatc aactcagctt cacatattcc atcatctaaa     2160

actgcatctc tccctggcta tggaagaaat gggcttcacc ggcctgtttc taccgacttc     2220

gctcagtata acagctatgg ggatgtcagc gggggagtgc gagaatatca gacactccca     2280

gatggccaca tgcctgcaat gagaatggac cgaggagtgt ctatgcccaa catgttggaa     2340

ccaaagatat ttccatatga aatgctcatg gtgaccaaca gagggcgaaa caaaatcctc     2400

agagaggtgg acagaaccag gctggagcgc cacttagccc ctgaagtgtt tcgggaaatc     2460

tttggaatgt ccatacagga gtttgacagg ttacctcttt ggagacgcaa cgacatgaag     2520

aaaaaagcaa aactcttcta agtcccactc gtgaatggca attagagaaa ggactgacag     2580

tggcggtgcc ccataggatg tcatattgag gcccaaactt gattggagaa tttgcaaact     2640

accgtcgctc agcaacacca aaaagagaaa gtctggttaa aacaccatga gtcaaatgtc     2700

gggccagcca acagtaacac ttgccaagaa gcatggcgta gaaatttcta tgttccgaaa     2760

cacagagtag tgtccacatg tgagcttttc acattacctt atgtatacaa caggagctgc     2820

gttgttttct tctttttctt ttcctttatc tgttgtccaa caacagtgct gactgtccgg     2880

ataagagctg gcaagtgccc ttaggatgcc gcatgggaaa aatcggttat cataatttca     2940

aagtataaat atatttatta agtagcgctg cggctaagaa ggaagagtga ggggtctgtc     3000

catggggtgg cagtgatttc acacccgcct ttcttgaatg gcttcgtgtt actcagccgt     3060

gccctggcag gaatggaact ccatcaggga acagggcagc tctgtttgaa tggggtgaaa     3120

aacagcaaaa ttaattctta gcaagctcct tgttctctac tgttcaccgg gacctggctg     3180

gcaaatgact tagctattag tatatttaaa aactgttcaa aagcaaaaga gaaggaacag     3240

gaatgaaagg aaaccttccc ttaactcttt ctgcttccca tagcaggtct ggttcctgct     3300

ccccgcctag gacaggagct gtctggagct ccacctttgc aaagaaagga aaaacacaaa     3360

ttgcccccag attggcccag tggcatgcca ttaggtgatt ttgcataggg gccatatcat     3420

tcatggccaa aaaaaaccaa aaagcaaaaa acaaaaacaa gtcccatgtc ctactgactc     3480

tagttcttcc agtcgttatc ctctgctgtc tctctggcat cctatgaatc agatcaagcc     3540

catgctgttg ttggttttta aggtttcttt caataatagg ctaaggaaag acatgttttt     3600

ctcttttaaa tctctgcaac tccaaagtag actccttcga acgtatttaa tttggccttt     3660

tcagctttct tcttgcccag ctctgtcgaa ttcatgggtg tgtgtgcaca tgttggtttc     3720

actcacccag agtaattttg tgagcatgca tgtgcttttt aatttctgct tgaatgtttg     3780

tcctgctgtg ttgcagcttc taaagacatt gtcaccgagt gtgtgtgact caaagatcaa     3840

gagtgaggct aaactgcgac cccaacatca cttccttcat ggaaaggtgt tggcgctgat     3900

gtagctcatg gaaggatcag actgggaacc acagaggaag gatgaggtgg gatgtggagg     3960

tcagagcatc tcacgagagt ccctcaggct ctgcaacact agattcgaat atgagcctag     4020

ggtttcccca acacgtgcgt gcatatgaaa ccacatcatg attcccgacg tgagttagat     4080

gagggagagt ttgtgtaact ccacacccag gagggtaagc cactttatta tcatgctttg     4140

gggctgtgct taagaattta agctctgttt taaagccgaa gaagaaaaca tttgaattta     4200

ccttcatatg ccactaagaa caaaagctct gaagttcttc ctgctggcac caaatattag     4260

gattacaagc tgtctctctg acaccagtgg taaaaaagca agtagaatag tttctgagtc     4320

tgtgttgcag cctctgacac gtggctcacc gctgtcattt gggggatgga atgaacagtc     4380

actgttctat agcatcctcc tgtgctctta cctaaggaat ctaaattgtc ctagccttcc     4440

attgctatgc actgaatgag gactactctc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     4500

gtgtgtgtgt gtgtgtgtgt tggatctact aacatgttta gcaaatggct ctgacagggt     4560

ggccatgagc agatgagacc agctcttgct tggttggaag ccacactgca gtttgcagtt     4620

tagcctttgg tgtctcagtg gcttcttgct tattccatgc tttttctatc ccatcctctc     4680

tctgtgccct cctgcaatgg cagccttggc acaatgcctg ggtgtcctca tccttgcttt     4740

actctggaaa gtgtggggat ggagaggatg gtgcatttcc agtgcttcct tacctgtcaa     4800

taacaatggt ggccacctgg gtcccagcac ttggctggtg gagagatttt tttcattatg     4860

gagctaataa agggtcccta cgttttacat tgattaatga attatcaccc agacatgtgc     4920

agatgaaatg tcaatataag aaaaatcaag gtatttggga aacatgggca taatcaggta     4980

gttttgctaa aattcctctt ccttggtcta cataaagaag acatgggtct gtcatagaat     5040

ggggacatta gactgaaaac tgggacaacc cccttcctta ttttatagag actaggagtt     5100

aaggggcctg cctaagattg cagtgataaa gaactgaacc ctaaatcagc tcccactaat     5160

gaaaccctgc tttccttgta tcttttaaac tcagttctgc atccaacttg agaagaaaaa     5220

aagcttcttt ccatatcaag taccatatga gttcatttaa actgcacctt gcagaaatgc     5280

attgccagaa agcaccagta gcctcctatc tgcaagcaga gtagtgctct gctctgggga     5340

ggggtcattg gaaaccataa tgcagagtgg gccccctact ccatttccca gcaaaaggct     5400

ccagctggag ggatgggttg tggggcaacc tggttcctgc taactgccag attgaatgtg     5460

tgggctagaa tgcctgcaca tttagttaaa ctgggctcag catgcttgtc ctcaaaatgt     5520

ccatcctggt cacagcacac aagatggcta ttggtctgct tttaccctac cctgtactat     5580

acatgaaaat tccagttatt aacacactca aactggtgga gcttgttcac cctaggaagg     5640

ggattgtata tatggcaggc ttccctggtg ccgatgtaaa gggctacatt tgggaacatt     5700

tgacttcctt gggactctta agtgcataat gatggcatga agtaaaaggg gcctcaatga     5760

tgataggaaa atcagttctt ttaaaatttc ttcaagaaaa tccaggctat cacatagtct     5820

ttctgtgtga cttattagga gataggaaga gcattgggaa acttgcacag ctagctatgc     5880

atctacattt tggtttgggg ttagttatga aatgttctta atatgacgtg ttcaataact     5940

tcacataaac ttcctgttct ccaaaacctc aaagagatag agttaatgag ttgttgtttt     6000

tttttaaatg ggggtagttt tctatctgtc atgggctcta gcatctactc cgctacccaa     6060

ttctgtcatc tccaagctga gtttcctctt ctgaggcaga ggctggagca gttctttttc     6120

agttctcatc ctctccatcc caatccagta tatcaatcaa ctctaactcg gagacgtcta     6180

gctggcaatg tttctaaaac tttcactgga tttctttaga cattgaagca aacatttttt     6240

tctaagaatt gcttctcaga tgatgatatc aaatgtatat gcttttgcaa gtttgaaaag     6300

ttcaaattaa ccacttttga ctaggtaagt ctttctaaaa accatttaaa gctaactggg     6360

tcttagcatc ctcctgtgta tggaagagac aggtgaccgc tccaggttgg gtgctcacag     6420

aacccttttc ctgactctca tggaagatgg tggaaggaaa atagactgtc tcatcaaccc     6480

tcctgtgtcc tctgaagcaa tctcagtttt tattaaccac ctcttctgtg tttctggtag     6540

ctatttaacc tgtatttaat ctgtacttcc tatgccagcc tcaattttat ttgattttta     6600

caattattct cttctaacca atgaagtgtt tgtcagtatg ccccaaagct tgctcttttg     6660

tgctcccttt tgaataactt tctatccaga aaaagagatt atttgggact tgagatttgc     6720

agtgatacca acttatagca atgatgtact ttaagggaac tacccaacta tgttgtgata     6780

gaagaaagag aaaccttcac tttggcattt ttttttaatc actgtttatt tttctgtttg     6840

cggcccagga agcagtggga ggtggtggca gatatgcttt gcatatggat tgttatgttt     6900

ttatttgggc aagtttaatc atggaaaact caaaaagaag gggggaaatg gtcagtttaa     6960

gccaaaagaa actttctaaa caatgtatag gtacacagca aaattaaaca aatccaacaa     7020

tttctgaagc ttagtgtaat tgagtggtgg ttgttattca ataaaattat tcccaaaagt     7080

gtttctccta agagtgcagt tcccatgagt cacttcctga acccattgac caaaggtgga     7140

cagagacaat cctgtagacc ttgacattca gaaagatgtg agctgcttac tgatcatata     7200

tgcatacgtt tctttacagc agaggaaacc attgtccaca aaactgatgt tcttttgggg     7260

ttttatgtac agacttgtcc aatcatgtgt gtggttcctg cgagttgctg atgactccgc     7320

attgaagctc tctgagttct ttgattttaa gttgggttta tggaattttt tcaaatgttg     7380

gaaggtgtgt ggttcttcct gccctccctc cccttttgga aatatgaaag caaatgttta     7440

gaagaattcc ttttgaaaag ctgtgtcgtg ttccctgtga aactgagcag gtgtgtgttg     7500

gcgcgctaag tgccacatgc ttgtgtgtag aggaggaggt ggccctgccg gctccgcgct     7560

gctgtgcctg tgatccctac ctgctccccg ctcctgttgc cagcagcact cactgcactc     7620

ctttgtcata tactctgcat cactgtcata ctcacaactt cgtgaataaa gttgtgtgct     7680

ttattcgt                                                              7688


<210> 1699
<211> 7256
<212> DNA
<213> Homo sapiens

<400> 1699
atggtgccag accctgtggc ccaccctcag gaccctcacc acccatcaga gaagcctgtc       60

attcactgcc ataaatgtgg ggagccttgc aagggtgaag tgcttcgggt ccagaccaaa      120

catttccaca tcaagtgttt cacctgcaaa gtgtgtggct gtgacctggc acaagggggc      180

ttcttcataa agaacggaga gtatctctgc accctggact accagcggat gtacgggaca      240

cgctgccatg gctgtgggga gttcgtggag ggcgaagtgg tgactgctct gggcaagacc      300

taccatccca attgctttgc ttgtactatc tgcaagcgcc cgtttccacc cggagaccga      360

gtcacattca atgggagaga ctgcctttgt caactctgtg cacagccgat gtcgtccagt      420

ccgaaagaaa ccaccttctc cagcaattgt gccggctgcg gaagagatat caagaatggg      480

caggcgctgc tggcgctgga taagcagtgg cacttggggt gctttaaatg caagtcctgc      540

gggaaggtcc tcaccgggga gtacatcagc aaggatggtg ctccgtactg tgaaaaggac      600

taccagggac tctttggggt gaaatgtgag gcgtgtcacc agtttatcac agggaaagtc      660

ctggaggcag gtgacaaaca ttaccacccc agctgtgcac gatgcagcag atgcaaccag      720

atgttcacag aaggagagga aatgtatctt caaggctcca ccgtttggca tcccgactgt      780

aagcaatcta cgaagaccga ggaaaagctg cggcctacca ggacatcctc ggaaagtatt      840

tattctaggc caggctccag tattcctggc tcaccaggtc atactatcta tgcaaaagta      900

gacaatgaga tcctggatta caaggattta gcagccattc cgaaggtcaa ggcaatttat      960

gacattgaac gtccagatct tattacctat gagcctttct acacttcggg ctatgatgac     1020

aaacaggaga gacagagcct tggagagtct ccgaggactt tgtctcctac tccatcagca     1080

gaagggtacc aggatgttcg ggatcggatg atccatcggt ccacgagcca gggctccatc     1140

aactcccctg tgtacagccg ccacagctac actccaacca cgtcccgctc tccccagcat     1200

ttccacagac ctggcaatga gccgtccagc ggccggaact cccctctccc ttaccggcca     1260

gacagccgcc ctctaactcc aacttacgct caggccccta aacatttcca tgttccagat     1320

caaggaatca acatttaccg aaagccaccc atctacaaac agcatgctgc cttggcagcc     1380

cagagcaagt cctcagaaga tatcatcaag ttttccaagt tcccagcagc ccaggcacca     1440

gaccccagcg agacaccaaa gattgagacg gaccactggc ctggtccccc ctcatttgct     1500

gtcgtaggac ctgacatgaa acgcagatct agtggcagag aggaagatga tgaggaactt     1560

ctgagacgtc ggcagcttca agaagagcaa ttaatgaagc ttaactcagg cctgggacag     1620

ttgatcttga aagaagagat ggagaaagag agccgggaaa ggtcatctct gttagccagt     1680

cgctacgatt ctcccatcaa ctcagcttca catattccat catctaaaac tgcatctctc     1740

cctggctatg gaagaaatgg gcttcaccgg cctgtttcta ccgacttcgc tcagtataac     1800

agctatgggg atgtcagcgg gggagtgcga gaatatcaga cactcccaga tggccacatg     1860

cctgcaatga gaatggaccg aggagtgtct atgcccaaca tgttggaacc aaagatattt     1920

ccatatgaaa tgctcatggt gaccaacaga gggcgaaaca aaatcctcag agaggtggac     1980

agaaccaggc tggagcgcca cttagcccct gaagtgtttc gggaaatctt tggaatgtcc     2040

atacaggagt ttgacaggtt acctctttgg agacgcaacg acatgaagaa aaaagcaaaa     2100

ctcttctaag tcccactcgt gaatggcaat tagagaaagg actgacagtg gcggtgcccc     2160

ataggatgtc atattgaggc ccaaacttga ttggagaatt tgcaaactac cgtcgctcag     2220

caacaccaaa aagagaaagt ctggttaaaa caccatgagt caaatgtcgg gccagccaac     2280

agtaacactt gccaagaagc atggcgtaga aatttctatg ttccgaaaca cagagtagtg     2340

tccacatgtg agcttttcac attaccttat gtatacaaca ggagctgcgt tgttttcttc     2400

tttttctttt cctttatctg ttgtccaaca acagtgctga ctgtccggat aagagctggc     2460

aagtgccctt aggatgccgc atgggaaaaa tcggttatca taatttcaaa gtataaatat     2520

atttattaag tagcgctgcg gctaagaagg aagagtgagg ggtctgtcca tggggtggca     2580

gtgatttcac acccgccttt cttgaatggc ttcgtgttac tcagccgtgc cctggcagga     2640

atggaactcc atcagggaac agggcagctc tgtttgaatg gggtgaaaaa cagcaaaatt     2700

aattcttagc aagctccttg ttctctactg ttcaccggga cctggctggc aaatgactta     2760

gctattagta tatttaaaaa ctgttcaaaa gcaaaagaga aggaacagga atgaaaggaa     2820

accttccctt aactctttct gcttcccata gcaggtctgg ttcctgctcc ccgcctagga     2880

caggagctgt ctggagctcc acctttgcaa agaaaggaaa aacacaaatt gcccccagat     2940

tggcccagtg gcatgccatt aggtgatttt gcataggggc catatcattc atggccaaaa     3000

aaaaccaaaa agcaaaaaac aaaaacaagt cccatgtcct actgactcta gttcttccag     3060

tcgttatcct ctgctgtctc tctggcatcc tatgaatcag atcaagccca tgctgttgtt     3120

ggtttttaag gtttctttca ataataggct aaggaaagac atgtttttct cttttaaatc     3180

tctgcaactc caaagtagac tccttcgaac gtatttaatt tggccttttc agctttcttc     3240

ttgcccagct ctgtcgaatt catgggtgtg tgtgcacatg ttggtttcac tcacccagag     3300

taattttgtg agcatgcatg tgctttttaa tttctgcttg aatgtttgtc ctgctgtgtt     3360

gcagcttcta aagacattgt caccgagtgt gtgtgactca aagatcaaga gtgaggctaa     3420

actgcgaccc caacatcact tccttcatgg aaaggtgttg gcgctgatgt agctcatgga     3480

aggatcagac tgggaaccac agaggaagga tgaggtggga tgtggaggtc agagcatctc     3540

acgagagtcc ctcaggctct gcaacactag attcgaatat gagcctaggg tttccccaac     3600

acgtgcgtgc atatgaaacc acatcatgat tcccgacgtg agttagatga gggagagttt     3660

gtgtaactcc acacccagga gggtaagcca ctttattatc atgctttggg gctgtgctta     3720

agaatttaag ctctgtttta aagccgaaga agaaaacatt tgaatttacc ttcatatgcc     3780

actaagaaca aaagctctga agttcttcct gctggcacca aatattagga ttacaagctg     3840

tctctctgac accagtggta aaaaagcaag tagaatagtt tctgagtctg tgttgcagcc     3900

tctgacacgt ggctcaccgc tgtcatttgg gggatggaat gaacagtcac tgttctatag     3960

catcctcctg tgctcttacc taaggaatct aaattgtcct agccttccat tgctatgcac     4020

tgaatgagga ctactctcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     4080

gtgtgtgttg gatctactaa catgtttagc aaatggctct gacagggtgg ccatgagcag     4140

atgagaccag ctcttgcttg gttggaagcc acactgcagt ttgcagttta gcctttggtg     4200

tctcagtggc ttcttgctta ttccatgctt tttctatccc atcctctctc tgtgccctcc     4260

tgcaatggca gccttggcac aatgcctggg tgtcctcatc cttgctttac tctggaaagt     4320

gtggggatgg agaggatggt gcatttccag tgcttcctta cctgtcaata acaatggtgg     4380

ccacctgggt cccagcactt ggctggtgga gagatttttt tcattatgga gctaataaag     4440

ggtccctacg ttttacattg attaatgaat tatcacccag acatgtgcag atgaaatgtc     4500

aatataagaa aaatcaaggt atttgggaaa catgggcata atcaggtagt tttgctaaaa     4560

ttcctcttcc ttggtctaca taaagaagac atgggtctgt catagaatgg ggacattaga     4620

ctgaaaactg ggacaacccc cttccttatt ttatagagac taggagttaa ggggcctgcc     4680

taagattgca gtgataaaga actgaaccct aaatcagctc ccactaatga aaccctgctt     4740

tccttgtatc ttttaaactc agttctgcat ccaacttgag aagaaaaaaa gcttctttcc     4800

atatcaagta ccatatgagt tcatttaaac tgcaccttgc agaaatgcat tgccagaaag     4860

caccagtagc ctcctatctg caagcagagt agtgctctgc tctggggagg ggtcattgga     4920

aaccataatg cagagtgggc cccctactcc atttcccagc aaaaggctcc agctggaggg     4980

atgggttgtg gggcaacctg gttcctgcta actgccagat tgaatgtgtg ggctagaatg     5040

cctgcacatt tagttaaact gggctcagca tgcttgtcct caaaatgtcc atcctggtca     5100

cagcacacaa gatggctatt ggtctgcttt taccctaccc tgtactatac atgaaaattc     5160

cagttattaa cacactcaaa ctggtggagc ttgttcaccc taggaagggg attgtatata     5220

tggcaggctt ccctggtgcc gatgtaaagg gctacatttg ggaacatttg acttccttgg     5280

gactcttaag tgcataatga tggcatgaag taaaaggggc ctcaatgatg ataggaaaat     5340

cagttctttt aaaatttctt caagaaaatc caggctatca catagtcttt ctgtgtgact     5400

tattaggaga taggaagagc attgggaaac ttgcacagct agctatgcat ctacattttg     5460

gtttggggtt agttatgaaa tgttcttaat atgacgtgtt caataacttc acataaactt     5520

cctgttctcc aaaacctcaa agagatagag ttaatgagtt gttgtttttt tttaaatggg     5580

ggtagttttc tatctgtcat gggctctagc atctactccg ctacccaatt ctgtcatctc     5640

caagctgagt ttcctcttct gaggcagagg ctggagcagt tctttttcag ttctcatcct     5700

ctccatccca atccagtata tcaatcaact ctaactcgga gacgtctagc tggcaatgtt     5760

tctaaaactt tcactggatt tctttagaca ttgaagcaaa catttttttc taagaattgc     5820

ttctcagatg atgatatcaa atgtatatgc ttttgcaagt ttgaaaagtt caaattaacc     5880

acttttgact aggtaagtct ttctaaaaac catttaaagc taactgggtc ttagcatcct     5940

cctgtgtatg gaagagacag gtgaccgctc caggttgggt gctcacagaa cccttttcct     6000

gactctcatg gaagatggtg gaaggaaaat agactgtctc atcaaccctc ctgtgtcctc     6060

tgaagcaatc tcagttttta ttaaccacct cttctgtgtt tctggtagct atttaacctg     6120

tatttaatct gtacttccta tgccagcctc aattttattt gatttttaca attattctct     6180

tctaaccaat gaagtgtttg tcagtatgcc ccaaagcttg ctcttttgtg ctcccttttg     6240

aataactttc tatccagaaa aagagattat ttgggacttg agatttgcag tgataccaac     6300

ttatagcaat gatgtacttt aagggaacta cccaactatg ttgtgataga agaaagagaa     6360

accttcactt tggcattttt ttttaatcac tgtttatttt tctgtttgcg gcccaggaag     6420

cagtgggagg tggtggcaga tatgctttgc atatggattg ttatgttttt atttgggcaa     6480

gtttaatcat ggaaaactca aaaagaaggg gggaaatggt cagtttaagc caaaagaaac     6540

tttctaaaca atgtataggt acacagcaaa attaaacaaa tccaacaatt tctgaagctt     6600

agtgtaattg agtggtggtt gttattcaat aaaattattc ccaaaagtgt ttctcctaag     6660

agtgcagttc ccatgagtca cttcctgaac ccattgacca aaggtggaca gagacaatcc     6720

tgtagacctt gacattcaga aagatgtgag ctgcttactg atcatatatg catacgtttc     6780

tttacagcag aggaaaccat tgtccacaaa actgatgttc ttttggggtt ttatgtacag     6840

acttgtccaa tcatgtgtgt ggttcctgcg agttgctgat gactccgcat tgaagctctc     6900

tgagttcttt gattttaagt tgggtttatg gaattttttc aaatgttgga aggtgtgtgg     6960

ttcttcctgc cctccctccc cttttggaaa tatgaaagca aatgtttaga agaattcctt     7020

ttgaaaagct gtgtcgtgtt ccctgtgaaa ctgagcaggt gtgtgttggc gcgctaagtg     7080

ccacatgctt gtgtgtagag gaggaggtgg ccctgccggc tccgcgctgc tgtgcctgtg     7140

atccctacct gctccccgct cctgttgcca gcagcactca ctgcactcct ttgtcatata     7200

ctctgcatca ctgtcatact cacaacttcg tgaataaagt tgtgtgcttt attcgt         7256


<210> 1700
<211> 6836
<212> DNA
<213> Homo sapiens

<400> 1700
gaggagagga ggcgtgagag agcgtgcctg cccgccgcac acggggctgg tttccggagt       60

gcgtctctag agggatgcac gttgccttag ccgagcttcg gagagaagcc tgatatgtaa      120

cccaggcagg tgggagcctc agtctgtcgg gctgaggtct ggcatctaca aagcctcttg      180

gccgtgttct gaacttgaag cctggaggag ttctctgctc agcacagcca aggaacagaa      240

ttagaagaaa aggaaccctg gcctgaggca ggtgacaaac attaccaccc cagctgtgca      300

cgatgcagca gatgcaacca gatgttcaca gaaggagagg aaatgtatct tcaaggctcc      360

accgtttggc atcccgactg taagcaatct acgaagaccg aggaaaagct gcggctgcca      420

aacattcggc gttcttcatc cgatttcttt tattccaaaa gtctgattcg acgcacagga      480

cggtctccgt ctctgcagcc taccaggaca tcctcggaaa gtatttattc taggccaggc      540

tccagtattc ctggctcacc aggtcatact atctatgcaa aagtagacaa tgagatcctg      600

gattacaagg atttagcagc cattccgaag gtcaaggcaa tttatgacat tgaacgtcca      660

gatcttatta cctatgagcc tttctacact tcgggctatg atgacaaaca ggagagacag      720

agccttggag agtctccgag gactttgtct cctactccat cagcagaagg gtaccaggat      780

gttcgggatc ggatgatcca tcggtccacg agccagggct ccatcaactc ccctgtgtac      840

agccgccaca gctacactcc aaccacgtcc cgctctcccc agcatttcca cagacctgat      900

caaggaatca acatttaccg aaagccaccc atctacaaac agcatgctgc cttggcagcc      960

cagagcaagt cctcagaaga tatcatcaag ttttccaagt tcccagcagc ccaggcacca     1020

gaccccagcg agacaccaaa gattgagacg gaccactggc ctggtccccc ctcatttgct     1080

gtcgtaggac ctgacatgaa acgcagatct agtggcagag aggaagatga tgaggaactt     1140

ctgagacgtc ggcagcttca agaagagcaa ttaatgaagc ttaactcagg cctgggacag     1200

ttgatcttga aagaagagat ggagaaagag agccgggaaa ggtcatctct gttagccagt     1260

cgctacgatt ctcccatcaa ctcagcttca catattccat catctaaaac tgcatctctc     1320

cctggctatg gaagaaatgg gcttcaccgg cctgtttcta ccgacttcgc tcagtataac     1380

agctatgggg atgtcagcgg gggagtgcga gatttccaga cactcccaga tggccacatg     1440

cctgcaatga gaatggaccg aggagtgtct atgcccaaca tgttggaacc aaagatattt     1500

ccatatgaaa tgctcatggt gaccaacaga gggcgaaaca aaatcctcag agaggtggac     1560

agaaccaggc tggagcgcca cttagcccct gaagtgtttc gggaaatctt tggaatgtcc     1620

atacaggagt ttgacaggtt acctctttgg agacgcaacg acatgaagaa aaaagcaaaa     1680

ctcttctaag tcccactcgt gaatggcaat tagagaaagg actgacagtg gcggtgcccc     1740

ataggatgtc atattgaggc ccaaacttga ttggagaatt tgcaaactac cgtcgctcag     1800

caacaccaaa aagagaaagt ctggttaaaa caccatgagt caaatgtcgg gccagccaac     1860

agtaacactt gccaagaagc atggcgtaga aatttctatg ttccgaaaca cagagtagtg     1920

tccacatgtg agcttttcac attaccttat gtatacaaca ggagctgcgt tgttttcttc     1980

tttttctttt cctttatctg ttgtccaaca acagtgctga ctgtccggat aagagctggc     2040

aagtgccctt aggatgccgc atgggaaaaa tcggttatca taatttcaaa gtataaatat     2100

atttattaag tagcgctgcg gctaagaagg aagagtgagg ggtctgtcca tggggtggca     2160

gtgatttcac acccgccttt cttgaatggc ttcgtgttac tcagccgtgc cctggcagga     2220

atggaactcc atcagggaac agggcagctc tgtttgaatg gggtgaaaaa cagcaaaatt     2280

aattcttagc aagctccttg ttctctactg ttcaccggga cctggctggc aaatgactta     2340

gctattagta tatttaaaaa ctgttcaaaa gcaaaagaga aggaacagga atgaaaggaa     2400

accttccctt aactctttct gcttcccata gcaggtctgg ttcctgctcc ccgcctagga     2460

caggagctgt ctggagctcc acctttgcaa agaaaggaaa aacacaaatt gcccccagat     2520

tggcccagtg gcatgccatt aggtgatttt gcataggggc catatcattc atggccaaaa     2580

aaaaccaaaa agcaaaaaac aaaaacaagt cccatgtcct actgactcta gttcttccag     2640

tcgttatcct ctgctgtctc tctggcatcc tatgaatcag atcaagccca tgctgttgtt     2700

ggtttttaag gtttctttca ataataggct aaggaaagac atgtttttct cttttaaatc     2760

tctgcaactc caaagtagac tccttcgaac gtatttaatt tggccttttc agctttcttc     2820

ttgcccagct ctgtcgaatt catgggtgtg tgtgcacatg ttggtttcac tcacccagag     2880

taattttgtg agcatgcatg tgctttttaa tttctgcttg aatgtttgtc ctgctgtgtt     2940

gcagcttcta aagacattgt caccgagtgt gtgtgactca aagatcaaga gtgaggctaa     3000

actgcgaccc caacatcact tccttcatgg aaaggtgttg gcgctgatgt agctcatgga     3060

aggatcagac tgggaaccac agaggaagga tgaggtggga tgtggaggtc agagcatctc     3120

acgagagtcc ctcaggctct gcaacactag attcgaatat gagcctaggg tttccccaac     3180

acgtgcgtgc atatgaaacc acatcatgat tcccgacgtg agttagatga gggagagttt     3240

gtgtaactcc acacccagga gggtaagcca ctttattatc atgctttggg gctgtgctta     3300

agaatttaag ctctgtttta aagccgaaga agaaaacatt tgaatttacc ttcatatgcc     3360

actaagaaca aaagctctga agttcttcct gctggcacca aatattagga ttacaagctg     3420

tctctctgac accagtggta aaaaagcaag tagaatagtt tctgagtctg tgttgcagcc     3480

tctgacacgt ggctcaccgc tgtcatttgg gggatggaat gaacagtcac tgttctatag     3540

catcctcctg tgctcttacc taaggaatct aaattgtcct agccttccat tgctatgcac     3600

tgaatgagga ctactctcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     3660

gtgtgtgttg gatctactaa catgtttagc aaatggctct gacagggtgg ccatgagcag     3720

atgagaccag ctcttgcttg gttggaagcc acactgcagt ttgcagttta gcctttggtg     3780

tctcagtggc ttcttgctta ttccatgctt tttctatccc atcctctctc tgtgccctcc     3840

tgcaatggca gccttggcac aatgcctggg tgtcctcatc cttgctttac tctggaaagt     3900

gtggggatgg agaggatggt gcatttccag tgcttcctta cctgtcaata acaatggtgg     3960

ccacctgggt cccagcactt ggctggtgga gagatttttt tcattatgga gctaataaag     4020

ggtccctacg ttttacattg attaatgaat tatcacccag acatgtgcag atgaaatgtc     4080

aatataagaa aaatcaaggt atttgggaaa catgggcata atcaggtagt tttgctaaaa     4140

ttcctcttcc ttggtctaca taaagaagac atgggtctgt catagaatgg ggacattaga     4200

ctgaaaactg ggacaacccc cttccttatt ttatagagac taggagttaa ggggcctgcc     4260

taagattgca gtgataaaga actgaaccct aaatcagctc ccactaatga aaccctgctt     4320

tccttgtatc ttttaaactc agttctgcat ccaacttgag aagaaaaaaa gcttctttcc     4380

atatcaagta ccatatgagt tcatttaaac tgcaccttgc agaaatgcat tgccagaaag     4440

caccagtagc ctcctatctg caagcagagt agtgctctgc tctggggagg ggtcattgga     4500

aaccataatg cagagtgggc cccctactcc atttcccagc aaaaggctcc agctggaggg     4560

atgggttgtg gggcaacctg gttcctgcta actgccagat tgaatgtgtg ggctagaatg     4620

cctgcacatt tagttaaact gggctcagca tgcttgtcct caaaatgtcc atcctggtca     4680

cagcacacaa gatggctatt ggtctgcttt taccctaccc tgtactatac atgaaaattc     4740

cagttattaa cacactcaaa ctggtggagc ttgttcaccc taggaagggg attgtatata     4800

tggcaggctt ccctggtgcc gatgtaaagg gctacatttg ggaacatttg acttccttgg     4860

gactcttaag tgcataatga tggcatgaag taaaaggggc ctcaatgatg ataggaaaat     4920

cagttctttt aaaatttctt caagaaaatc caggctatca catagtcttt ctgtgtgact     4980

tattaggaga taggaagagc attgggaaac ttgcacagct agctatgcat ctacattttg     5040

gtttggggtt agttatgaaa tgttcttaat atgacgtgtt caataacttc acataaactt     5100

cctgttctcc aaaacctcaa agagatagag ttaatgagtt gttgtttttt tttaaatggg     5160

ggtagttttc tatctgtcat gggctctagc atctactccg ctacccaatt ctgtcatctc     5220

caagctgagt ttcctcttct gaggcagagg ctggagcagt tctttttcag ttctcatcct     5280

ctccatccca atccagtata tcaatcaact ctaactcgga gacgtctagc tggcaatgtt     5340

tctaaaactt tcactggatt tctttagaca ttgaagcaaa catttttttc taagaattgc     5400

ttctcagatg atgatatcaa atgtatatgc ttttgcaagt ttgaaaagtt caaattaacc     5460

acttttgact aggtaagtct ttctaaaaac catttaaagc taactgggtc ttagcatcct     5520

cctgtgtatg gaagagacag gtgaccgctc caggttgggt gctcacagaa cccttttcct     5580

gactctcatg gaagatggtg gaaggaaaat agactgtctc atcaaccctc ctgtgtcctc     5640

tgaagcaatc tcagttttta ttaaccacct cttctgtgtt tctggtagct atttaacctg     5700

tatttaatct gtacttccta tgccagcctc aattttattt gatttttaca attattctct     5760

tctaaccaat gaagtgtttg tcagtatgcc ccaaagcttg ctcttttgtg ctcccttttg     5820

aataactttc tatccagaaa aagagattat ttgggacttg agatttgcag tgataccaac     5880

ttatagcaat gatgtacttt aagggaacta cccaactatg ttgtgataga agaaagagaa     5940

accttcactt tggcattttt ttttaatcac tgtttatttt tctgtttgcg gcccaggaag     6000

cagtgggagg tggtggcaga tatgctttgc atatggattg ttatgttttt atttgggcaa     6060

gtttaatcat ggaaaactca aaaagaaggg gggaaatggt cagtttaagc caaaagaaac     6120

tttctaaaca atgtataggt acacagcaaa attaaacaaa tccaacaatt tctgaagctt     6180

agtgtaattg agtggtggtt gttattcaat aaaattattc ccaaaagtgt ttctcctaag     6240

agtgcagttc ccatgagtca cttcctgaac ccattgacca aaggtggaca gagacaatcc     6300

tgtagacctt gacattcaga aagatgtgag ctgcttactg atcatatatg catacgtttc     6360

tttacagcag aggaaaccat tgtccacaaa actgatgttc ttttggggtt ttatgtacag     6420

acttgtccaa tcatgtgtgt ggttcctgcg agttgctgat gactccgcat tgaagctctc     6480

tgagttcttt gattttaagt tgggtttatg gaattttttc aaatgttgga aggtgtgtgg     6540

ttcttcctgc cctccctccc cttttggaaa tatgaaagca aatgtttaga agaattcctt     6600

ttgaaaagct gtgtcgtgtt ccctgtgaaa ctgagcaggt gtgtgttggc gcgctaagtg     6660

ccacatgctt gtgtgtagag gaggaggtgg ccctgccggc tccgcgctgc tgtgcctgtg     6720

atccctacct gctccccgct cctgttgcca gcagcactca ctgcactcct ttgtcatata     6780

ctctgcatca ctgtcatact cacaacttcg tgaataaagt tgtgtgcttt attcgt         6836


<210> 1701
<211> 7690
<212> DNA
<213> Homo sapiens

<400> 1701
gtcattgagc tgatgtgctt ttgcaagggg tctctttaga agtggtaggg gcagggtcga       60

gagaagaagg ggatgcagaa tctgtacatg aggaaggagc cagagtcact caggaaactc      120

ctcattcttc ctgcgctggc tgtggcacac ccaccggtgg cacacccctc cctcgggtcc      180

agttcagccc acagactcct gggaggagag ccagggcccc agcctctcct ttgaggagtg      240

ttgcagcctt tctgtgtgcc agatgcctag tgaagaaaag ctgaaaccct ggagctttgt      300

gcatgttaat gaccttggaa atgactgagc tcacggaccc tcatcacacc atgggagact      360

acaaagtggc ccaccctcag gaccctcacc acccatcaga gaagcctgtc attcactgcc      420

ataaatgtgg ggagccttgc aagggtgaag tgcttcgggt ccagaccaaa catttccaca      480

tcaagtgttt cacctgcaaa gtgtgtggct gtgacctggc acaagggggc ttcttcataa      540

agaacggaga gtatctctgc accctggact accagcggat gtacgggaca cgctgccatg      600

gctgtgggga gttcgtggag ggcgaagtgg tgactgctct gggcaagacc taccatccca      660

attgctttgc ttgtactatc tgcaagcgcc cgtttccacc cggagaccga gtcacattca      720

atgggagaga ctgcctttgt caactctgtg cacagccgat gtcgtccagt ccgaaagaaa      780

ccaccttctc cagcaattgt gccggctgcg gaagagatat caagaatggg caggcgctgc      840

tggcgctgga taagcagtgg cacttggggt gctttaaatg caagtcctgc gggaaggtcc      900

tcaccgggga gtacatcagc aaggatggtg ctccgtactg tgaaaaggac taccagggac      960

tctttggggt gaaatgtgag gcgtgtcacc agtttatcac agggaaagtc ctggaggcag     1020

gtgacaaaca ttaccacccc agctgtgcac gatgcagcag atgcaaccag atgttcacag     1080

aaggagagga aatgtatctt caaggctcca ccgtttggca tcccgactgt aagcaatcta     1140

cgaagaccga ggaaaagctg cggctgccaa acattcggcg ttcttcatcc gatttctttt     1200

attccaaaag tctgattcga cgcacaggac ggtctccgtc tctgcagcct accaggacat     1260

cctcggaaag tatttattct aggccaggct ccagtattcc tggctcacca ggtcatacta     1320

tctatgcaaa agtagacaat gagatcctgg attacaagga tttagcagcc attccgaagg     1380

tcaaggcaat ttatgacatt gaacgtccag atcttattac ctatgagcct ttctacactt     1440

cgggctatga tgacaaacag gagagacaga gccttggaga gtctccgagg actttgtctc     1500

ctactccatc agcagaaggg taccaggatg ttcgggatcg gatgatccat cggtccacga     1560

gccagggctc catcaactcc cctgtgtaca gccgccacag ctacactcca accacgtccc     1620

gctctcccca gcatttccac agacctggca atgagccgtc cagcggccgg aactcccctc     1680

tcccttaccg gccagacagc cgccctctaa ctccaactta cgctcaggcc cctaaacatt     1740

tccatgttcc agatcaagga atcaacattt accgaaagcc acccatctac aaacagcatg     1800

ctgccttggc agcccagagc aagtcctcag aagatatcat caagttttcc aagttcccag     1860

cagcccaggc accagacccc agcgagacac caaagattga gacggaccac tggcctggtc     1920

ccccctcatt tgctgtcgta ggacctgaca tgaaacgcag atctagtggc agagaggaag     1980

atgatgagga acttctgaga cgtcggcagc ttcaagaaga gcaattaatg aagcttaact     2040

caggcctggg acagttgatc ttgaaagaag agatggagaa agagagccgg gaaaggtcat     2100

ctctgttagc cagtcgctac gattctccca tcaactcagc ttcacatatt ccatcatcta     2160

aaactgcatc tctccctggc tatggaagaa atgggcttca ccggcctgtt tctaccgact     2220

tcgctcagta taacagctat ggggatgtca gcgggggagt gcgagatttc cagacactcc     2280

cagatggcca catgcctgca atgagaatgg accgaggagt gtctatgccc aacatgttgg     2340

aaccaaagat atttccatat gaaatgctca tggtgaccaa cagagggcga aacaaaatcc     2400

tcagagaggt ggacagaacc aggctggagc gccacttagc ccctgaagtg tttcgggaaa     2460

tctttggaat gtccatacag gagtttgaca ggttacctct ttggagacgc aacgacatga     2520

agaaaaaagc aaaactcttc taagtcccac tcgtgaatgg caattagaga aaggactgac     2580

agtggcggtg ccccatagga tgtcatattg aggcccaaac ttgattggag aatttgcaaa     2640

ctaccgtcgc tcagcaacac caaaaagaga aagtctggtt aaaacaccat gagtcaaatg     2700

tcgggccagc caacagtaac acttgccaag aagcatggcg tagaaatttc tatgttccga     2760

aacacagagt agtgtccaca tgtgagcttt tcacattacc ttatgtatac aacaggagct     2820

gcgttgtttt cttctttttc ttttccttta tctgttgtcc aacaacagtg ctgactgtcc     2880

ggataagagc tggcaagtgc ccttaggatg ccgcatggga aaaatcggtt atcataattt     2940

caaagtataa atatatttat taagtagcgc tgcggctaag aaggaagagt gaggggtctg     3000

tccatggggt ggcagtgatt tcacacccgc ctttcttgaa tggcttcgtg ttactcagcc     3060

gtgccctggc aggaatggaa ctccatcagg gaacagggca gctctgtttg aatggggtga     3120

aaaacagcaa aattaattct tagcaagctc cttgttctct actgttcacc gggacctggc     3180

tggcaaatga cttagctatt agtatattta aaaactgttc aaaagcaaaa gagaaggaac     3240

aggaatgaaa ggaaaccttc ccttaactct ttctgcttcc catagcaggt ctggttcctg     3300

ctccccgcct aggacaggag ctgtctggag ctccaccttt gcaaagaaag gaaaaacaca     3360

aattgccccc agattggccc agtggcatgc cattaggtga ttttgcatag gggccatatc     3420

attcatggcc aaaaaaaacc aaaaagcaaa aaacaaaaac aagtcccatg tcctactgac     3480

tctagttctt ccagtcgtta tcctctgctg tctctctggc atcctatgaa tcagatcaag     3540

cccatgctgt tgttggtttt taaggtttct ttcaataata ggctaaggaa agacatgttt     3600

ttctctttta aatctctgca actccaaagt agactccttc gaacgtattt aatttggcct     3660

tttcagcttt cttcttgccc agctctgtcg aattcatggg tgtgtgtgca catgttggtt     3720

tcactcaccc agagtaattt tgtgagcatg catgtgcttt ttaatttctg cttgaatgtt     3780

tgtcctgctg tgttgcagct tctaaagaca ttgtcaccga gtgtgtgtga ctcaaagatc     3840

aagagtgagg ctaaactgcg accccaacat cacttccttc atggaaaggt gttggcgctg     3900

atgtagctca tggaaggatc agactgggaa ccacagagga aggatgaggt gggatgtgga     3960

ggtcagagca tctcacgaga gtccctcagg ctctgcaaca ctagattcga atatgagcct     4020

agggtttccc caacacgtgc gtgcatatga aaccacatca tgattcccga cgtgagttag     4080

atgagggaga gtttgtgtaa ctccacaccc aggagggtaa gccactttat tatcatgctt     4140

tggggctgtg cttaagaatt taagctctgt tttaaagccg aagaagaaaa catttgaatt     4200

taccttcata tgccactaag aacaaaagct ctgaagttct tcctgctggc accaaatatt     4260

aggattacaa gctgtctctc tgacaccagt ggtaaaaaag caagtagaat agtttctgag     4320

tctgtgttgc agcctctgac acgtggctca ccgctgtcat ttgggggatg gaatgaacag     4380

tcactgttct atagcatcct cctgtgctct tacctaagga atctaaattg tcctagcctt     4440

ccattgctat gcactgaatg aggactactc tcgtgtgtgt gtgtgtgtgt gtgtgtgtgt     4500

gtgtgtgtgt gtgtgtgtgt gttggatcta ctaacatgtt tagcaaatgg ctctgacagg     4560

gtggccatga gcagatgaga ccagctcttg cttggttgga agccacactg cagtttgcag     4620

tttagccttt ggtgtctcag tggcttcttg cttattccat gctttttcta tcccatcctc     4680

tctctgtgcc ctcctgcaat ggcagccttg gcacaatgcc tgggtgtcct catccttgct     4740

ttactctgga aagtgtgggg atggagagga tggtgcattt ccagtgcttc cttacctgtc     4800

aataacaatg gtggccacct gggtcccagc acttggctgg tggagagatt tttttcatta     4860

tggagctaat aaagggtccc tacgttttac attgattaat gaattatcac ccagacatgt     4920

gcagatgaaa tgtcaatata agaaaaatca aggtatttgg gaaacatggg cataatcagg     4980

tagttttgct aaaattcctc ttccttggtc tacataaaga agacatgggt ctgtcataga     5040

atggggacat tagactgaaa actgggacaa cccccttcct tattttatag agactaggag     5100

ttaaggggcc tgcctaagat tgcagtgata aagaactgaa ccctaaatca gctcccacta     5160

atgaaaccct gctttccttg tatcttttaa actcagttct gcatccaact tgagaagaaa     5220

aaaagcttct ttccatatca agtaccatat gagttcattt aaactgcacc ttgcagaaat     5280

gcattgccag aaagcaccag tagcctccta tctgcaagca gagtagtgct ctgctctggg     5340

gaggggtcat tggaaaccat aatgcagagt gggcccccta ctccatttcc cagcaaaagg     5400

ctccagctgg agggatgggt tgtggggcaa cctggttcct gctaactgcc agattgaatg     5460

tgtgggctag aatgcctgca catttagtta aactgggctc agcatgcttg tcctcaaaat     5520

gtccatcctg gtcacagcac acaagatggc tattggtctg cttttaccct accctgtact     5580

atacatgaaa attccagtta ttaacacact caaactggtg gagcttgttc accctaggaa     5640

ggggattgta tatatggcag gcttccctgg tgccgatgta aagggctaca tttgggaaca     5700

tttgacttcc ttgggactct taagtgcata atgatggcat gaagtaaaag gggcctcaat     5760

gatgatagga aaatcagttc ttttaaaatt tcttcaagaa aatccaggct atcacatagt     5820

ctttctgtgt gacttattag gagataggaa gagcattggg aaacttgcac agctagctat     5880

gcatctacat tttggtttgg ggttagttat gaaatgttct taatatgacg tgttcaataa     5940

cttcacataa acttcctgtt ctccaaaacc tcaaagagat agagttaatg agttgttgtt     6000

tttttttaaa tgggggtagt tttctatctg tcatgggctc tagcatctac tccgctaccc     6060

aattctgtca tctccaagct gagtttcctc ttctgaggca gaggctggag cagttctttt     6120

tcagttctca tcctctccat cccaatccag tatatcaatc aactctaact cggagacgtc     6180

tagctggcaa tgtttctaaa actttcactg gatttcttta gacattgaag caaacatttt     6240

tttctaagaa ttgcttctca gatgatgata tcaaatgtat atgcttttgc aagtttgaaa     6300

agttcaaatt aaccactttt gactaggtaa gtctttctaa aaaccattta aagctaactg     6360

ggtcttagca tcctcctgtg tatggaagag acaggtgacc gctccaggtt gggtgctcac     6420

agaacccttt tcctgactct catggaagat ggtggaagga aaatagactg tctcatcaac     6480

cctcctgtgt cctctgaagc aatctcagtt tttattaacc acctcttctg tgtttctggt     6540

agctatttaa cctgtattta atctgtactt cctatgccag cctcaatttt atttgatttt     6600

tacaattatt ctcttctaac caatgaagtg tttgtcagta tgccccaaag cttgctcttt     6660

tgtgctccct tttgaataac tttctatcca gaaaaagaga ttatttggga cttgagattt     6720

gcagtgatac caacttatag caatgatgta ctttaaggga actacccaac tatgttgtga     6780

tagaagaaag agaaaccttc actttggcat ttttttttaa tcactgttta tttttctgtt     6840

tgcggcccag gaagcagtgg gaggtggtgg cagatatgct ttgcatatgg attgttatgt     6900

ttttatttgg gcaagtttaa tcatggaaaa ctcaaaaaga aggggggaaa tggtcagttt     6960

aagccaaaag aaactttcta aacaatgtat aggtacacag caaaattaaa caaatccaac     7020

aatttctgaa gcttagtgta attgagtggt ggttgttatt caataaaatt attcccaaaa     7080

gtgtttctcc taagagtgca gttcccatga gtcacttcct gaacccattg accaaaggtg     7140

gacagagaca atcctgtaga ccttgacatt cagaaagatg tgagctgctt actgatcata     7200

tatgcatacg tttctttaca gcagaggaaa ccattgtcca caaaactgat gttcttttgg     7260

ggttttatgt acagacttgt ccaatcatgt gtgtggttcc tgcgagttgc tgatgactcc     7320

gcattgaagc tctctgagtt ctttgatttt aagttgggtt tatggaattt tttcaaatgt     7380

tggaaggtgt gtggttcttc ctgccctccc tccccttttg gaaatatgaa agcaaatgtt     7440

tagaagaatt ccttttgaaa agctgtgtcg tgttccctgt gaaactgagc aggtgtgtgt     7500

tggcgcgcta agtgccacat gcttgtgtgt agaggaggag gtggccctgc cggctccgcg     7560

ctgctgtgcc tgtgatccct acctgctccc cgctcctgtt gccagcagca ctcactgcac     7620

tcctttgtca tatactctgc atcactgtca tactcacaac ttcgtgaata aagttgtgtg     7680

ctttattcgt                                                            7690


<210> 1702
<211> 3560
<212> DNA
<213> Homo sapiens

<400> 1702
tctttggtgc tgggaggcgg gccgcagggt agctgttggc gccgccgcgt ttctgggcct       60

ggccaactca cgtgaccgac gcgggctctg aagcggtggg ccgcaccgag gcggcggcgg      120

cggcgacgac tgcagctcgg gaggtagcgg cctggcgagg gacgggccgg ctgccctctc      180

ggacggccgc ggcggagggc aaaaatggcg gaggcttcgg cggccggggc ggactcgggc      240

gccgctgtag ccgcccaccg gtttttctgc cacttttgca agggcgaggt cagccccaaa      300

ctaccggaat atatatgtcc cagatgtgaa tcaggcttta ttgaagaagt gacagatgat      360

tccagttttt taggtggtgg cggcagtcgg atagacaata ccacaacaac acattttgca      420

gagctttggg gccatttgga tcacacgatg ttttttcaag attttagacc ctttctaagt      480

agcagtccac tggaccaaga taatagagcc aatgaaaggg gtcaccagac tcacactgac      540

ttctggggag caagacctcc acggttgcca ttgggtcgga gatacagatc tcgaggaagt      600

tctcgtcctg acagatctcc agctattgaa ggaatactac aacacatctt tgcaggattc      660

tttgcaaatt ctgccattcc tggatctcca cacccttttt cctggagcgg gatgctgcac      720

tccaaccctg gggactatgc ctggggtcag acagggcttg atgccattgt aacccagctt      780

ttaggacaac tggaaaacac aggccctccc ccagctgaca aggaaaagat cacatctctt      840

ccaacagtga cagtaactca ggaacaagtt gatatgggtt tagagtgtcc agtatgcaaa      900

gaagattaca cagttgaaga ggaagtccgg cagttacctt gcaatcactt ctttcacagc      960

agttgtattg tgccgtggct agaactgcat gacacatgtc ctgtatgtag gaagagctta     1020

aatggtgagg actctactcg gcaaagccag agcactgagg cctctgcaag caacagattt     1080

agcaatgaca gtcagctaca tgaccgatgg actttctgaa gctaaagacc acacctgaat     1140

cagggctgtg gtaatcatct taccatagct gtaaattgta tcaaaacaaa aaattagtag     1200

atggatttag gaatatgtaa gaaactcaac acataatata aatgcaatga atgtttttct     1260

tctttaaatt taaagttagt atctacagat ggaattgtat ctacaaccaa atgcctctta     1320

tccctgaatt cagagtgata attttataag tgtgaaactt aattatgtag ggctcccccc     1380

gtctgaatag aattaattcc ttaaagtcta gttagggtcc tgctgtctgt catgttgcct     1440

tgtaacggat gtttccacct ccttctccaa cctctacccc accattagtg tattttacta     1500

taaaaacagt ggaaccacag ccctaaagtc ctgctgatat aaagtccttt tgtcttaatt     1560

gtatttaaaa aaaaaaaaaa actactcttg atcacattag ctatgaggcg aggtcaaatt     1620

caggtatcta agactaatga ttttgttttg tcttgatccc cagagagcaa atcaaagaaa     1680

aattacagca agaagagaaa agtggtttat cattgtgtgc tttggttttc ttattttaat     1740

tttttttgtt tttttttttt gagatggagt ctcgctctgt cgcctaggct ggagtgcagt     1800

ggcacgatct tggctcattg caaactctgc ctcctgagtt caagcgattc tcctacctca     1860

gcctccagag tagctgggac cacaggcatt tgttaccatg cccagctaat tttttgtata     1920

tttagtagag atggggtttc accgtgttag ccaggatggt ctcaatctcc tgaccttgtg     1980

ctccgcctgc ctcagcctcc caaagtgctg ggattacagg cgtgagccac tgcgcctggc     2040

ctcttatttt aatttttaaa gactacttca gttgatgcag tttcccaaga aacctacata     2100

acatatattg ggagccttat gttgatagga atctgattcc cattcctttt tgggaatgag     2160

ttgggcagca tacaggcaca gaaagacaga tgtttgagac ctttgcttct gagattttaa     2220

aaaatgatta ccgctgggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg     2280

aggcaggcgg atcacaaggt caagagatca agaccagcct ggccaacaag gtaaaacctt     2340

gtctctacta aaaatataaa attagctggg cctggtggtg catgcctgta atcccagcta     2400

ctcatgaggc tgaggtggga gaatcgcttg aacccaggag gtggaggttg cggtgagccg     2460

gatcatacca atgcactcca gtctgggcaa caagagcgaa actccatctc aaaaaaaaaa     2520

aaaaaatccc caactcactg ctttttttgt ttgtttctgt cgcctaggct ggagtgcagt     2580

ggcacgatct cagctcacca cagcctcgac ctcccaggct caagtgatcc tcccacctca     2640

gcctaccaag tggctgggac tacaggcgtg tgccaccatg cctgggtaat ttttgtattt     2700

ttgtagagat agggttttgc cgtgttgccc aggctggtct caaactcctg ggctcaagtg     2760

atctgcctgc ctcaacctct caaagtgctc aactcattgt ttactgtctt ttttcctagt     2820

aatcttaaaa taatttgcct cacagaaata gagacagtaa gtgtctgcag ccagttcact     2880

gtttttggta attcattggt cttcaggagt taagatttta cattgtcaca ttttaatttt     2940

taagcctatt tttcatctct gaaactttcc ttttctcctt ggttctggct atacttggac     3000

tcaaactgat cagtgtgatc atgtccaaaa cagcttggcc tggaagaggt aggccttatt     3060

ttttcagcct agtagtgtcc catgcacatg ctctttgtag cattcaagtg tttaacattg     3120

gataaattaa gaaggtcaag aatgttgttg aaacttcaag gtctcaaaag gaaatgatgg     3180

ggacatagaa caactgttgg tgtaccaaaa aaaggtacag aggggcacca tttgtattgt     3240

cacacaacaa tgatcagaat gatcagttta gaatgatcag aacaaaaaca ccactcttta     3300

atgggtcttt ttcttggcta gaagtctttc ctcagttttt gttgactatc atacgctgat     3360

ttgtgggtga cggaaggggg ctagagataa cgtttctctg tactttggta aaggatgaag     3420

gagtcagaga gggaacagaa aaagtgagag agtggcctgc tgaaataata gcctgcctct     3480

aaaagttgtg accagaaagt atgattcatt tgggcccaga gggaataaaa tatgtttttt     3540

catatacctc ccatattaca                                                 3560


<210> 1703
<211> 5506
<212> DNA
<213> Homo sapiens

<400> 1703
aatgctgaga cagactccca gaagatctga gcgagtcgcg tagctgagcc cggcaggggc       60

tggggtggtg ctgctgctat gagctgcacc atcgagaaga tcctgacaga cgccaagacg      120

ctgctggaga ggctacggga gcacgatgcg gccgccgagt cgctggtgga tcagtcggcg      180

gcgctgcacc ggcgggtagc agctatgcgg gaggcgggga cagcgcttcc ggaccaggtc      240

aggcagaggt atcaagagga tgcatccgat atgaaggaca tgtccaaata caaacctcac      300

attctgctgt cccaagagaa cacacagatt agagacttgc aacaggaaaa cagagagcta      360

tggatttcct tggaggaaca ccaggatgct ttggaactta tcatgagcaa atatcggaaa      420

cagatgttac agttaatggt tgctaaaaaa gcggtggatg ctgaaccagt cctgaaagct      480

caccagtctc actctgcaga aattgagagt cagattgaca gaatctgtga aatgggagaa      540

gtgatgagga aagcagttca ggtggatgat gaccagtttt gtaagattca ggaaaaatta      600

gcccaattag agcttgaaaa taaggaactt cgagaattat tgtccatcag cagtgagtct      660

cttcaagcca gaaaggaaaa ctcaatggac actgcttccc aagccatcaa ataactgaac      720

tctgaatgat ggctggagat tgtctatcaa ggaaggaagt tactgtcttc ccattcaagt      780

actgtccatt aagtgtcttg cctcagattt gatttaatct taattaaagg tatcaggtgg      840

caatttagaa ttccagtcaa tattggctgt ccacagttct cagatgtgtt aatgtgaata      900

ctacatgctg aatttcacca ttcctttctc aaagagacta cttttaattt tcatttctgg      960

gaccttgatt tatataaact atgttttcag ttctttgtta tttttcacat ctctgaaact     1020

ttgagcattt tttataagcc agcaatttat tttacatagc attgtaaaat acacttctag     1080

gaaattttag gaaagattta actgtttaaa tctatttggc ataaaccttg attttttttt     1140

tccatttgac aaaaataata caattccaca gaactagatc agcagattct ctgatttgta     1200

atgtcattca cctgtgacat tttaagtctc tctggtgcta agaattggca ctttatagcc     1260

tggtgccttt acttttaatt tgagagaacc tactgctagt cccaggaaac acacttggaa     1320

ataagtcagc tatttttttt gcccagtgat gctatagttg tcatattgtc caaagttcat     1380

attgttcaaa gctgaggagc ttgtcctgtg tatgtgaatg cacacatgtg cacttagttc     1440

aaatactaaa agtagctttt attaaatata atcagccaaa aacacacaca aaataaaaaa     1500

aacaaatata agtagtcagt ttttcaatgt tatcctacta gttctacatt ctattttaat     1560

ttttatacaa tttccatttt atagttaaga accatcactt acttggattg gatgtctttc     1620

attcctagca ctaatagttg gctttctttt tttttgttta catagaagca gggttttttt     1680

ttatcttttt tctttttttt tgtttaagct atataaaaag gtgaggaagc agttttgtta     1740

cctaatgaaa attattacac tcataatgct gtgtaggcaa cattgagatt caaatgccca     1800

gtggtcaact gggttcactc atcaactcat tcccgtccca gtttactcac atttcaaatt     1860

tataaatttc ttcatgttat actattctat ttagatttgc ccagaattag ttgaaataat     1920

gctaaacctg tcaatatttt ccagtaacat taagcaccat actgcatggg agagacacag     1980

tactaaaaag agttgttagt gctttatgtg agtgatattt ctttcgtaat gctataaaga     2040

actacagtta aaataacaaa atattttaaa gatgtcctaa aagcatctga tcccagtaat     2100

aactaatgga tgtcatctag agcagtgggt gttaatgaat aggtatatgt catttaagaa     2160

tttttcaaat ttctgtttga tatcctgcat agaatttgac aaaaaaaaca cttccaagtg     2220

tgagcatttt ttatttcatt tcccaagagt aagtaagtaa ctattagccc agccatctgc     2280

ctcgaagtat accttaagtg accccataaa tccattcaag aggcaggtac tctataccat     2340

ttggcagcca cggccaaacc taccatggcc agatttcagt gaaaatgatg aagtaatcaa     2400

atcaaggtat aatatggtgt ccctttatgt gctttatgtt cctttagagc tgtttataaa     2460

gttctttata tctcaagtgt taggataaat cgacatacta acttttcccc ctgcaaaatt     2520

aaaagcctga ggtacaagtc taagaagctt ttagtgctct acataatata aattctggct     2580

ggtgttaatg ctatgaagat aatatgtagt tagaaaattg agtcggggag gaatgctctt     2640

cattttaagt ggattttaaa gtttctcctt gagtggatga agaacttgcc tggtttgcaa     2700

aaatcttagt tcaaaattat attttctaac aaaaactgca ttttgagaag ataagctaat     2760

tttactcagt agtaagtcaa atgaggaagt gcagagggtt tttttacata tatatagcaa     2820

ccttgtcaag tggtcctcac aagagtcata aatactttgt aattagcaca gtatattcag     2880

cagtgtataa ctctacaaat agtaccttat attagtgtag tattatatca atatcttatg     2940

tataattctt atattaatac cttatgcata attggattca aacattgaag gtctatttta     3000

gtgttcttca aaatgtgctt ccctgaccta ctgaaataga aacttggtga tgaagttcaa     3060

gaatttgtat tctaatcatc tcaaacaatt cctaaagaca ctgattttaa aatatctagt     3120

ctaggcccca ttgtgtaata gttagcactc taaaagatga aaaagaaaat agtctatgtg     3180

ccaaccactt cattagtact tatgaattta aaaatgaaaa agtctggtac aggagacaag     3240

tatatatata aaattataat gcagtgtgat aaatccatta tagtatgtat aagatacaga     3300

agagggactt taaacttgag aattcaatag agataataaa tgggtaggag ggaaatagaa     3360

aactttggtg ccacaaaagc aaagtatgta tggtattgcc aataatagct accatctatt     3420

gagtgcttta ctacctgtca ggtactgtat tatataaact ccattttaac tgtacctcat     3480

tttgcagata ctcaggcaca aggaggtggt tatttgtcca aactggaacc aagattcaaa     3540

cccagacaga gtcttaagca catttttaat cactaactaa cttgagatgc ctaaatgcca     3600

aatactgttg ggagttcaag tggttcttga ttagcaaaat ctatttttat tagtgcaaaa     3660

gaaacaccac agcttataaa gtattatgaa ttcaataaat ggagtcttaa ctaatgagat     3720

attattttct agaatggtgt agctgagagt atgtgtgatt caactgaaag gaataatgtt     3780

taatcagtga ctcttactat atacaggaaa aggtgcagtt ctgtctttca aatctgcctc     3840

cttaccatat tggcttacat ccctcatgct gttttcttgt gtttgctaga aagttgttgc     3900

caagccaaat gtcatggcca tgttgaaggc aaggaagaaa aaatggaaat ggcctgtgcc     3960

agctatatat atcgcctttt atgagggaaa gcaaagcttt ctcagaaatc ccaaatggat     4020

tttcccttga cttaattgcc tgaccagtta aatggccact ggtacctgca aagaaagcag     4080

ggtacatagc tgtcccaaat aaaatcagta ttagcaagaa gaaagaatat tgagaaagca     4140

attaacagtg tctgtgactg tgacatgtct gtgactttat attgtcaagt cctttcccct     4200

tgaatatagt tttggaagaa ttagctgaag gagtgtgttg acattgaatg gccaagagaa     4260

tgggctgtag cagacatctg tcatttctct tttggctgcc cagtatccta actcctgtgt     4320

ttaaggaatc cctcacctaa tgaggcagag catttcttcc tcctaaagaa tttgaaagta     4380

ccaggtaatg ttttctcagc ctccttttgc agctaaggaa gaaacatctg ccttcaattt     4440

taaaattagt gatacaaaga aggagggaac catgcagatt cctttgaaga tggtgattaa     4500

caacactact gcattcatct ccacagaggt acagcaaaag tgatttagtt agcgataacc     4560

tctaattcta tttttttatt tttatttttt gagacagtct tgctctgtca accaggctgg     4620

agtgcagtag cactgtctta actcactgca acctccacct cctgggttca agcgattctc     4680

ctgcctcagc ctcccaagtc gctgggatta caagtgccca ccaccatgca cagctaattt     4740

ttgtgttttt agtagatggg gtttctccat gttggccagg ctggtctcga acttatgact     4800

tcaggtgatc cgcccgcctt ggcctcccaa agtgctggga ttataggcgt gagccactgt     4860

gcctggcctg taacctctaa ttcttgtttg ctggctgtcc tagagatcct gagaattact     4920

tttaataaaa tcattttttt gctgttatta aaactaacct gaattgccta aaaccaagaa     4980

ctctgcttga taaaataagc atagttttag gaacagccat gcagatataa attttatcaa     5040

cactttatac ataatttggg acttatattt aaatgtaata tttgatgctt ataaaagggt     5100

aaatggggaa tgcaaataaa ttatcaagca taataactca tcacctaact taagaataac     5160

attatgagtg cttgtatttt atctatttga gctcttctcc tatctttgcc gacccccccg     5220

ctctcttttt aatagatttg ttcgaatgta gaaagaccta aaatacatat gtatccctaa     5280

agtgacttat tttatagttt tctttctttt tgaacttcaa aaaaattgta tcatactcta     5340

tgtagtctaa ggatttggtt tttttcactc aacatgtctc tagaattcac aagttttatt     5400

gttttatagc tgtcattttc attgatgtat atttcattgt tgggttatac aacatattgt     5460

taaggaatac atacatatat aataaattat acatttttta aaaaaa                    5506


<210> 1704
<211> 2883
<212> DNA
<213> Homo sapiens

<400> 1704
agattgtttc acatcaccag tgtatcctca gctcctaaca ctgtgtctgg tacacattgt       60

ttgatggttt tgatgtttca gattcgttat atttcacaaa cacaaggctt gccagctgaa      120

tatcttctca gtgccggaac aaaaacaacc aggtttttca acagagatcc taatttgggg      180

tacccactgt ggaggcttaa gacacctgaa gaacatgaac tggagactgg aataaaatca      240

aaagaagctc ggaagtacat ttttaattgc ttagatgaca tggctcaggt gaatatgtct      300

acagacctgg agggaacaga catgttggca gagaaggcag accgaagaga atacattgat      360

ctgttaaaga aaatgctcac aattgatgca gataagagaa ttacccctct aaaaactctt      420

aaccatcagt ttgtgacaat gactcacctt ttggattttc cacatagcaa tcatgttaag      480

tcttgttttc agaacatgga gatctgcaag cggagggttc acatgtatga tacagtgagt      540

cagatcaaga gtcccttcac tacacatgtt gccccaaata caagcacaaa tctaaccatg      600

agcttcagca atcagctcaa tacagtgcac aatcaggcca gtgttctagc ttccagttct      660

actgcagcag ctgctactct ttctctggct aattcagatg tctcactact aaactaccag      720

tcagctttgt acccatcatc tgctgcacca gttcctggag ttgcccagca gggtgtttcc      780

ttgcagcctg gaaccaccca gatttgcact cagacagatc cattccaaca gacatttata      840

gtatgtccac ctgcgtttca aactggacta caagcaacaa caaagcattc tggattccct      900

gtgaggatgg ataatgctgt accgattgta ccccaggcac cagctgctca gccactacag      960

attcagtcag gagttctcac gcagggaagc tgtacaccac taatggtagc aactctccac     1020

cctcaagtag ccaccatcac accgcagtat gcggtgccct ttactctgag ctgcgcagcc     1080

ggccggccgg cgctggttga acagactgcc gctgtactgc aggcgtggcc tggagggact     1140

cagcaaattc tcctgccttc aacttggcaa cagttgcctg gggtagctct acacaactct     1200

gtccagccca cagcaatgat tccagaggcc atggggagtg gacagcagct agctgactgg     1260

aggaatgccc actctcatgg caaccagtac agcactatca tgcagcagcc atccttgctg     1320

actaaccatg tgacattggc cactgctcag cctctgaatg ttggtgttgc ccatgttgtc     1380

agacaacaac aatccagttc cctcccttcg aagaagaata agcagtcagc tccagtctct     1440

tccaagtcct ctctagatgt tctgccttcc caagtctatt ctctggttgg gagcagtccc     1500

ctccgcacca catcttctta taattccttg gtccctgtcc aagatcagca tcagcccatc     1560

atcattccag atactcccag ccctcctgtg agtgtcatca ctatccgaag tgacactgat     1620

gaggaagagg acaacaaata caagcccagt agctctggac tgaagccaag gtctaatgtc     1680

atcagttatg tcactgtcaa tgattctcca gactctgact cttctttgag cagcccttat     1740

tccactgata ccctgagtgc tctccgaggc aatagtggat ccgttttgga ggggcctggc     1800

agagttgtgg cagatggcac tggcacccgc actatcattg tgcctccact gaaaactcag     1860

cttggtgact gcactgtagc aacccaggcc tcaggtctcc tgagcaataa gactaagcca     1920

gtcgcttcag tgagtgggca gtcatctgga tgctgtatca cccccacagg gtatcgagct     1980

caacgcgggg ggaccagtgc agcacaacca ctcaatctta gccagaacca gcagtcatcg     2040

gcggctccaa cctcacagga gagaagcagc aacccagccc cccgcaggca gcaggcgttt     2100

gtggcccctc tctcccaagc cccctacacc ttccagcatg gcagcccgct acactcgaca     2160

gggcacccac accttgcccc ggcccctgct cacctgccaa gccaggctca tctgtatacg     2220

tatgctgccc cgacttctgc tgctgcactg ggctcaacca gctccattgc tcatcttttc     2280

tccccacagg gttcctcaag gcatgctgca gcctatacca ctcaccctag cactttggtg     2340

caccaggtcc ctgtcagtgt tgggcccagc ctcctcactt ctgccagcgt ggcccctgct     2400

cagtaccaac accagtttgc cacccaatcc tacattgggt cttcccgagg ctcaacaatt     2460

tacactggat acccgctgag tcctaccaag atcagccagt attcctactt atagttggtg     2520

agcatgaggg aggaggaatc atggctacct tctcctggcc ctgcgttctt aatattgggc     2580

tatggagaga tcctccttta ccctcttgaa atttcttagc cagcaacttg ttctgcaggg     2640

gcccactgaa gcagaaggtt tttctctggg ggaacctgtc tcagtgttga ctgcattgtt     2700

gtagtcttcc caaagtttgc cctattttta aattcattat ttttgtgaca gtaattttgg     2760

tacttggaag agttcagatg cccatcttct gcagttacca aggaagagag attgttctga     2820

agttaccctc tgaaaaatat tttgtctctc tgacttgatt tctataaatg cttttaaaaa     2880

caa                                                                   2883


<210> 1705
<211> 7947
<212> DNA
<213> Homo sapiens

<400> 1705
gcagagtctg cagtgcggag ggggcgggaa gtccaggccc cgcactcgat ccacgctggc       60

tccctacgga ggcccaccta ctcgaggccc accgactcct actgcaatca gtactatgcg      120

atcgtcctag agagtccatt cagctgcact tccgcctcag tatggcatca cagctgcaag      180

tgttttcgcc cccatcagtg tcgtcgagtg ccttctgcag tgcgaagaaa ctgaaaatag      240

agccctctgg ctgggatgtt tcaggacaga gtagcaacga caaatattat acccacagca      300

aaaccctccc agccacacaa gggcaagcca actcctctca ccaggtagca aatttcaaca      360

tccctgctta cgaccagggc ctcctcctcc cagctcctgc agtggagcat attgttgtaa      420

cagccgctga tagctcgggc agtgctgcta catcaacctt ccaaagcagc cagaccctga      480

ctcacagaag caacgtttct ttgcttgagc catatcaaaa atgtggattg aaacgaaaaa      540

gtgaggaagt tgacagcaac ggtagtgtgc agatcataga agaacatccc cctctcatgc      600

tgcaaaacag gactgtggtg ggtgctgctg ccacaaccac cactgtgacc acaaagagta      660

gcagttccag cggagaaggg gattaccagc tggtccagca tgagatcctt tgctctatga      720

ccaatagcta tgaagtcttg gagttcctag gccgggggac atttggacag gtggctaagt      780

gctggaagag gagcaccaag gaaattgtgg ctattaaaat cttgaagaac cacccctcct      840

atgccagaca aggacagatt gaagtgagca tcctttcccg cctaagcagt gaaaatgctg      900

atgagtataa ttttgtccgt tcatacgagt gctttcagca taagaatcac acctgccttg      960

tttttgaaat gttggagcag aacttatatg attttctaaa gcaaaacaaa tttagcccac     1020

tgccactcaa gtacatcaga ccaatcttgc agcaggtggc cacagccttg atgaagctca     1080

agagtcttgg tctgatccac gctgacctta agcctgaaaa catcatgctg gttgatccag     1140

ttcgccagcc ctaccgagtg aaggtcattg actttggttc tgctagtcac gtttccaaag     1200

ctgtgtgctc aacctactta cagtcacgtt actacagagc tcctgaaatt attcttgggt     1260

taccattttg tgaagctatt gatatgtggt cactgggctg tgtgatagct gagctgttcc     1320

tgggatggcc tctttatcct ggtgcttcag aatatgatca gattcgttat atttcacaaa     1380

cacaaggctt gccagctgaa tatcttctca gtgccggaac aaaaacaacc aggtttttca     1440

acagagatcc taatttgggg tacccactgt ggaggcttaa gacacctgaa gaacatgaac     1500

tggagactgg aataaaatca aaagaagctc ggaagtacat ttttaattgc ttagatgaca     1560

tggctcaggt gaatatgtct acagacctgg agggaacaga catgttggca gagaaggcag     1620

accgaagaga atacattgat ctgttaaaga aaatgctcac aattgatgca gataagagaa     1680

ttacccctct aaaaactctt aaccatcagt ttgtgacaat gactcacctt ttggattttc     1740

cacatagcaa tcatgttaag tcttgttttc agaacatgga gatctgcaag cggagggttc     1800

acatgtatga tacagtgagt cagatcaaga gtcccttcac tacacatgtt gccccaaata     1860

caagcacaaa tctaaccatg agcttcagca atcagctcaa tacagtgcac aatcaggcca     1920

gtgttctagc ttccagttct actgcagcag ctgctactct ttctctggct aattcagatg     1980

tctcactact aaactaccag tcagctttgt acccatcatc tgctgcacca gttcctggag     2040

ttgcccagca gggtgtttcc ttgcagcctg gaaccaccca gatttgcact cagacagatc     2100

cattccaaca gacatttata gtatgtccac ctgcgtttca aactggacta caagcaacaa     2160

caaagcattc tggattccct gtgaggatgg ataatgctgt accgattgta ccccaggcac     2220

cagctgctca gccactacag attcagtcag gagttctcac gcagcaggcg tggcctggag     2280

ggactcagca aattctcctg ccttcaactt ggcaacagtt gcctggggta gctctacaca     2340

actctgtcca gcccacagca atgattccag aggccatggg gagtggacag cagctagctg     2400

actggaggaa tgcccactct catggcaacc agtacagcac tatcatgcag cagccatcct     2460

tgctgactaa ccatgtgaca ttggccactg ctcagcctct gaatgttggt gttgcccatg     2520

ttgtcagaca acaacaatcc agttccctcc cttcgaagaa gaataagcag tcagctccag     2580

tctcttccaa gtcctctcta gatgttctgc cttcccaagt ctattctctg gttgggagca     2640

gtcccctccg caccacatct tcttataatt ccttggtccc tgtccaagat cagcatcagc     2700

ccatcatcat tccagatact cccagccctc ctgtgagtgt catcactatc cgaagtgaca     2760

ctgatgagga agaggacaac aaatacaagc ccagtagctc tggactgaag ccaaggtcta     2820

atgtcatcag ttatgtcact gtcaatgatt ctccagactc tgactcttct ttgagcagcc     2880

cttattccac tgataccctg agtgctctcc gaggcaatag tggatccgtt ttggaggggc     2940

ctggcagagt tgtggcagat ggcactggca cccgcactat cattgtgcct ccactgaaaa     3000

ctcagcttgg tgactgcact gtagcaaccc aggcctcagg tctcctgagc aataagacta     3060

agccagtcgc ttcagtgagt gggcagtcat ctggatgctg tatcaccccc acagggtatc     3120

gagctcaacg cggggggacc agtgcagcac aaccactcaa tcttagccag aaccagcagt     3180

catcggcggc tccaacctca caggagagaa gcagcaaccc agccccccgc aggcagcagg     3240

cgtttgtggc ccctctctcc caagccccct acaccttcca gcatggcagc ccgctacact     3300

cgacagggca cccacacctt gccccggccc ctgctcacct gccaagccag gctcatctgt     3360

atacgtatgc tgccccgact tctgctgctg cactgggctc aaccagctcc attgctcatc     3420

ttttctcccc acagggttcc tcaaggcatg ctgcagccta taccactcac cctagcactt     3480

tggtgcacca ggtccctgtc agtgttgggc ccagcctcct cacttctgcc agcgtggccc     3540

ctgctcagta ccaacaccag tttgccaccc aatcctacat tgggtcttcc cgaggctcaa     3600

caatttacac tggatacccg ctgagtccta ccaagatcag ccagtattcc tacttatagt     3660

tggtgagcat gagggaggag gaatcatggc taccttctcc tggccctgcg ttcttaatat     3720

tgggctatgg agagatcctc ctttaccctc ttgaaatttc ttagccagca acttgttctg     3780

caggggccca ctgaagcaga aggtttttct ctgggggaac ctgtctcagt gttgactgca     3840

ttgttgtagt cttcccaaag tttgccctat ttttaaattc attatttttg tgacagtaat     3900

tttggtactt ggaagagttc agatgcccat cttctgcagt taccaaggaa gagagattgt     3960

tctgaagtta ccctctgaaa aatattttgt ctctctgact tgatttctat aaatgctttt     4020

aaaaacaagt gaagcccctc tttatttcat tttgtgttat tgtgattgct ggtcaggaaa     4080

aatgctgata gaaggagttg aaatctgatg acaaaaaaag aaaaattact ttttgtttgt     4140

ttataaactc agacttgcct attttatttt aaaagcggct tacacaatct cccttttgtt     4200

tattggacat ttaaacttac agagtttcag ttttgtttta atgtcatatt atacttaatg     4260

ggcaattgtt atttttgcaa aactggttac gtattactct gtgttactat tgagattctc     4320

tcaattgctc ctgtgtttgt tataaagtag tgtttaaaag gcagctcacc atttgctggt     4380

aacttaatgt gagagaatcc atatctgcgt gaaaacacca agtattcttt ttaaatgaag     4440

caccatgaat tcttttttaa attatttttt aaaagtcttt ctctctctga ttcagcttaa     4500

atttttttat cgaaaaagcc attaaggtgg ttattattac atggtggtgg tggttttatt     4560

atatgcaaaa tctctgtcta ttatgagata ctggcattga tgagctttgc ctaaagatta     4620

gtatgaattt tcagtaatac acctctgttt tgctcatctc tcccttctgt tttatgtgat     4680

ttgtttgggg agaaagctaa aaaaacctga aaccagataa gaacatttct tgtgtatagc     4740

ttttatactt caaagtagct tcctttgtat gccagcagca aattgaatgc tctcttatta     4800

agacttatat aataagtgca tgtaggaatt gcaaaaaata ttttaaaaat ttattactga     4860

atttaaaaat attttagaag ttttgtaatg gtggtgtttt aatattttac ataattaaat     4920

atgtacatat tgattagaaa aatataacaa gcaatttttc ctgctaaccc aaaatgttat     4980

ttgtaatcaa atgtgtagtg attacacttg aattgtgtac ttagtgtgta tgtgatcctc     5040

cagtgttatc ccggagatgg attgatgtct ccattgtatt taaaccaaaa tgaactgata     5100

cttgttggaa tgtatgtgaa ctaattgcaa ttatattaga gcatattact gtagtgctga     5160

atgagcaggg gcattgcctg caaggagagg agacccttgg aattgttttg cacaggtgtg     5220

tctggtgagg agtttttcag tgtgtgtctc ttccttccct ttcttcctcc ttcccttatt     5280

gtagtgcctt atatgataat gtagtggtta atagagttta cagtgagctt gccttaggat     5340

ggaccagcaa gcccccgtgg accctaagtt gttcaccggg atttatcaga acaggattag     5400

tagctgtatt gtgtaatgca ttgttctcag tttccctgcc aacattgaaa aataaaaaca     5460

gcagcttttc tcctttacca ccacctctac ccctttccat tttggattct cggctgagtt     5520

ctcacagaag cattttcccc atgtggctct ctcactgtgc gttgctacct tgcttctgtg     5580

agaattcagg aagcaggtga gaggagtcaa gccaatatta aatatgcatt cttttaaagt     5640

atgtgcaatc acttttagaa tgaatttttt tttccttttc ccatgtggca gtccttcctg     5700

cacatagttg acattcctag taaaatattt gcttgttgaa aaaaacatgt taacagatgt     5760

gtttatacca aagagcctgt tgtattgctt accatgtccc catactatga ggagaagttt     5820

tgtggtgccg ctggtgacaa ggaactcaca gaaaggtttc ttagctggtg aagaatatag     5880

agaaggaacc aaagcctgtt gagtcattga ggcttttgag gtttcttttt taacagcttg     5940

tatagtcttg gggcccttca agctgtgaaa ttgtccttgt actctcagct cctgcatgga     6000

tctgggtcaa gtagaaggta ctggggatgg ggacattcct gcccataaag gatttgggga     6060

aagaagatta atcctaaaat acaggtgtgt tccatctgaa ttgaaaatga tatatttgag     6120

atataatttt aggactggtt ctgtgtagat agagatggtg tcaaggaggt gcaggatgga     6180

gatgggagat ttcatggagc ctggtcagcc agctctgtac caggttgaac accgaggagc     6240

tgtcaaagta tttggagttt cttcattgta aggagtaagg gcttccaaga tggggcaggt     6300

agtccgtaca gcctaccagg aacatgttgt gttttcttta ttttttaaaa tcattatatt     6360

gagttgtgtt ttcagcacta tattggtcaa gatagccaag cagtttgtat aatttctgtc     6420

actagtgtca tacagttttc tggtcaacat gtgtgatctt tgtgtctcct ttttgccaag     6480

cacattctga ttttcttgtt ggaacacagg tctagtttct aaaggacaaa ttttttgttc     6540

cttgtctttt ttctgtaagg gacaagattt gttgtttttg taagaaatga gatgcaggaa     6600

agaaaaccaa atcccattcc tgcaccccag tccaataagc agataccact taagatagga     6660

gtctaaactc cacagaaaag gataatacca agagcttgta ttgttacctt agtcacttgc     6720

ctagcagtgt gtggctttaa aaactagaga tttttcagtc ttagtctgca aactggcatt     6780

tccgattttc cagcataaaa atccacctgt gtctgctgaa tgtgtatgta tgtgctcact     6840

gtggctttag attctgtccc tggggttagc cctgttggcc ctgacaggaa gggaggaagc     6900

ctggtgaatt tagtgagcag ctggcctggg tcacagtgac ctgacctcaa accagcttaa     6960

ggctttaagt cctctctcag aacttggcat ttccaacttc ttcctttccg ggtgagagaa     7020

gaagcggaga agggttcagt gtagccactc tgggctcata gggacacttg gtcactccag     7080

agtttttaat agctcccagg aggtgatatt attttcagtg ctcagctgaa ataccaaccc     7140

caggaataag aactccattt caaacagttc tggccattct gagcctgctt ttgtgattgc     7200

tcatccattg tcctccacta gaggggctaa gcttgactgc ccttagccag gcaagcacag     7260

taatgtgtgt tttgttcagc attattatgc aaaaattcac tagttgagat ggtttgtttt     7320

aggataggaa atgaaattgc ctctcagtga caggagtggc ccgagcctgc ttcctatttt     7380

gatttttttt ttttttaact gatagatggt gcagcatgtc tacatggttg tttgttgcta     7440

aactttatat aatgtgtggt ttcaattcag cttgaaaaat aatctcacta catgtagcag     7500

tacattatat gtacattata tgtaatgtta gtatttctgc tttgaatcct tgatattgca     7560

atggaattcc tactttatta aatgtatttg atatgctagt tattgtgtgc gatttaaact     7620

ttttttgctt tctccctttt tttggttgtg cgctttcttt tacaacaagc ctctagaaac     7680

agatagtttc tgagaattac tgagctatgt ttgtaatgca gatgtactta gggagtatgt     7740

aaaataatca ttttaacaaa agaaatagat atttaaaatt taatactaac tatgggaaaa     7800

gggtccattg tgtaaaacat agtttatctt tggattcaat gtttgtcttt ggttttacaa     7860

agtagcttgt attttcagta ttttctacat aatatggtaa aatgtagagc aattgcaatg     7920

catcaataaa atgggtaaat tttctga                                         7947


<210> 1706
<211> 4099
<212> DNA
<213> Homo sapiens

<400> 1706
gaggcggcgg cggcggcggc gggaaggggc tgggtggtgg agcgggaggg aggctgagga       60

ggctccccct gcgggacggg cgcggggacg gctccggggg gcgggggccg gggcccgggc      120

cggctcgcgc ggggggtatg atgacccggc tgcggggccc cagatctcgt ctcctccgcc      180

gcctcctcac ggcagcccca gctcgcggct gagaaccaga cacaccggcg gtatggcatc      240

acagctgcaa gtgttttcgc ccccatcagt gtcgtcgagt gccttctgca gtgcgaagaa      300

actgaaaata gagccctctg gctgggatgt ttcaggacag agtagcaacg acaaatatta      360

tacccacagc aaaaccctcc cagccacaca agggcaagcc aactcctctc accaggtagc      420

aaatttcaac atccctgctt acgaccaggg cctcctcctc ccagctcctg cagtggagca      480

tattgttgta acagccgctg atagctcggg cagtgctgct acatcaacct tccaaagcag      540

ccagaccctg actcacagaa gcaacgtttc tttgcttgag ccatatcaaa aatgtggatt      600

gaaacgaaaa agtgaggaag ttgacagcaa cggtagtgtg cagatcatag aagaacatcc      660

ccctctcatg ctgcaaaaca ggactgtggt gggtgctgct gccacaacca ccactgtgac      720

cacaaagagt agcagttcca gcggagaagg ggattaccag ctggtccagc atgagatcct      780

ttgctctatg accaatagct atgaagtctt ggagttccta ggccggggga catttggaca      840

ggtggctaag tgctggaaga ggagcaccaa ggaaattgtg gctattaaaa tcttgaagaa      900

ccacccctcc tatgccagac aaggacagat tgaagtgagc atcctttccc gcctaagcag      960

tgaaaatgct gatgagtata attttgtccg ttcatacgag tgctttcagc ataagaatca     1020

cacctgcctt gtttttgaaa tgttggagca gaacttatat gattttctaa agcaaaacaa     1080

atttagccca ctgccactca agtacatcag accaatcttg cagcaggtgg ccacagcctt     1140

gatgaagctc aagagtcttg gtctgatcca cgctgacctt aagcctgaaa acatcatgct     1200

ggttgatcca gttcgccagc cctaccgagt gaaggtcatt gactttggtt ctgctagtca     1260

cgtttccaaa gctgtgtgct caacctactt acagtcacgt tactacagag ctcctgaaat     1320

tattcttggg ttaccatttt gtgaagctat tgatatgtgg tcactgggct gtgtgatagc     1380

tgagctgttc ctgggatggc ctctttatcc tggtgcttca gaatatgatc agattcgtta     1440

tatttcacaa acacaaggct tgccagctga atatcttctc agtgccggaa caaaaacaac     1500

caggtttttc aacagagatc ctaatttggg gtacccactg tggaggctta agacacctga     1560

agaacatgaa ctggagactg gaataaaatc aaaagaagct cggaagtaca tttttaattg     1620

cttagatgac atggctcagg tgaatatgtc tacagacctg gagggaacag acatgttggc     1680

agagaaggca gaccgaagag aatacattga tctgttaaag aaaatgctca caattgatgc     1740

agataagaga attacccctc taaaaactct taaccatcag tttgtgacaa tgactcacct     1800

tttggatttt ccacatagca atcatgttaa gtcttgtttt cagaacatgg agatctgcaa     1860

gcggagggtt cacatgtatg atacagtgag tcagatcaag agtcccttca ctacacatgt     1920

tgccccaaat acaagcacaa atctaaccat gagcttcagc aatcagctca atacagtgca     1980

caatcaggcc agtgttctag cttccagttc tactgcagca gctgctactc tttctctggc     2040

taattcagat gtctcactac taaactacca gtcagctttg tacccatcat ctgctgcacc     2100

agttcctgga gttgcccagc agggtgtttc cttgcagcct ggaaccaccc agatttgcac     2160

tcagacagat ccattccaac agacatttat agtatgtcca cctgcgtttc aaactggact     2220

acaagcaaca acaaagcatt ctggattccc tgtgaggatg gataatgctg taccgattgt     2280

accccaggca ccagctgctc agccactaca gattcagtca ggagttctca cgcagcaggc     2340

gtggcctgga gggactcagc aaattctcct gccttcaact tggcaacagt tgcctggggt     2400

agctctacac aactctgtcc agcccacagc aatgattcca gaggccatgg ggagtggaca     2460

gcagctagct gactggagga atgcccactc tcatggcaac cagtacagca ctatcatgca     2520

gcagccatcc ttgctgacta accatgtgac attggccact gctcagcctc tgaatgttgg     2580

tgttgcccat gttgtcagac aacaacaatc cagttccctc ccttcgaaga agaataagca     2640

gtcagctcca gtctcttcca agtcctctct agatgttctg ccttcccaag tctattctct     2700

ggttgggagc agtcccctcc gcaccacatc ttcttataat tccttggtcc ctgtccaaga     2760

tcagcatcag cccatcatca ttccagatac tcccagccct cctgtgagtg tcatcactat     2820

ccgaagtgac actgatgagg aagaggacaa caaatacaag cccagtagct ctggactgaa     2880

gccaaggtct aatgtcatca gttatgtcac tgtcaatgat tctccagact ctgactcttc     2940

tttgagcagc ccttattcca ctgataccct gagtgctctc cgaggcaata gtggatccgt     3000

tttggagggg cctggcagag ttgtggcaga tggcactggc acccgcacta tcattgtgcc     3060

tccactgaaa actcagcttg gtgactgcac tgtagcaacc caggcctcag gtctcctgag     3120

caataagact aagccagtcg cttcagtgag tgggcagtca tctggatgct gtatcacccc     3180

cacagggtat cgagctcaac gcggggggac cagtgcagca caaccactca atcttagcca     3240

gaaccagcag tcatcggcgg ctccaacctc acaggagaga agcagcaacc cagccccccg     3300

caggcagcag gcgtttgtgg cccctctctc ccaagccccc tacaccttcc agcatggcag     3360

cccgctacac tcgacagggc acccacacct tgccccggcc cctgctcacc tgccaagcca     3420

ggctcatctg tatacgtatg ctgccccgac ttctgctgct gcactgggct caaccagctc     3480

cattgctcat cttttctccc cacagggttc ctcaaggcat gctgcagcct ataccactca     3540

ccctagcact ttggtgcacc aggtccctgt cagtgttggg cccagcctcc tcacttctgc     3600

cagcgtggcc cctgctcagt accaacacca gtttgccacc caatcctaca ttgggtcttc     3660

ccgaggctca acaatttaca ctggataccc gctgagtcct accaagatca gccagtattc     3720

ctacttatag ttggtgagca tgagggagga ggaatcatgg ctaccttctc ctggccctgc     3780

gttcttaata ttgggctatg gagagatcct cctttaccct cttgaaattt cttagccagc     3840

aacttgttct gcaggggccc actgaagcag aaggtttttc tctgggggaa cctgtctcag     3900

tgttgactgc attgttgtag tcttcccaaa gtttgcccta tttttaaatt cattattttt     3960

gtgacagtaa ttttggtact tggaagagtt cagatgccca tcttctgcag ttaccaagga     4020

agagagattg ttctgaagtt accctctgaa aaatattttg tctctctgac ttgatttcta     4080

taaatgcttt taaaaacaa                                                  4099


<210> 1707
<211> 8157
<212> DNA
<213> Homo sapiens

<400> 1707
gaggcggcgg cggcggcggc gggaaggggc tgggtggtgg agcgggaggg aggctgagga       60

ggctccccct gcgggacggg cgcggggacg gctccggggg gcgggggccg gggcccgggc      120

cggctcgcgc ggggggtatg atgacccggc tgcggggccc cagatctcgt ctcctccgcc      180

gcctcctcac ggcagcccca gctcgcggct gagaaccaga cacaccggcg gtatggcatc      240

acagctgcaa gtgttttcgc ccccatcagt gtcgtcgagt gccttctgca gtgcgaagaa      300

actgaaaata gagccctctg gctgggatgt ttcaggacag agtagcaacg acaaatatta      360

tacccacagc aaaaccctcc cagccacaca agggcaagcc aactcctctc accaggtagc      420

aaatttcaac atccctgctt acgaccaggg cctcctcctc ccagctcctg cagtggagca      480

tattgttgta acagccgctg atagctcggg cagtgctgct acatcaacct tccaaagcag      540

ccagaccctg actcacagaa gcaacgtttc tttgcttgag ccatatcaaa aatgtggatt      600

gaaacgaaaa agtgaggaag ttgacagcaa cggtagtgtg cagatcatag aagaacatcc      660

ccctctcatg ctgcaaaaca ggactgtggt gggtgctgct gccacaacca ccactgtgac      720

cacaaagagt agcagttcca gcggagaagg ggattaccag ctggtccagc atgagatcct      780

ttgctctatg accaatagct atgaagtctt ggagttccta ggccggggga catttggaca      840

ggtggctaag tgctggaaga ggagcaccaa ggaaattgtg gctattaaaa tcttgaagaa      900

ccacccctcc tatgccagac aaggacagat tgaagtgagc atcctttccc gcctaagcag      960

tgaaaatgct gatgagtata attttgtccg ttcatacgag tgctttcagc ataagaatca     1020

cacctgcctt gtttttgaaa tgttggagca gaacttatat gattttctaa agcaaaacaa     1080

atttagccca ctgccactca agtacatcag accaatcttg cagcaggtgg ccacagcctt     1140

gatgaagctc aagagtcttg gtctgatcca cgctgacctt aagcctgaaa acatcatgct     1200

ggttgatcca gttcgccagc cctaccgagt gaaggtcatt gactttggtt ctgctagtca     1260

cgtttccaaa gctgtgtgct caacctactt acagtcacgt tactacagag ctcctgaaat     1320

tattcttggg ttaccatttt gtgaagctat tgatatgtgg tcactgggct gtgtgatagc     1380

tgagctgttc ctgggatggc ctctttatcc tggtgcttca gaatatgatc agattcgtta     1440

tatttcacaa acacaaggct tgccagctga atatcttctc agtgccggaa caaaaacaac     1500

caggtttttc aacagagatc ctaatttggg gtacccactg tggaggctta agacacctga     1560

agaacatgaa ctggagactg gaataaaatc aaaagaagct cggaagtaca tttttaattg     1620

cttagatgac atggctcagg tgaatatgtc tacagacctg gagggaacag acatgttggc     1680

agagaaggca gaccgaagag aatacattga tctgttaaag aaaatgctca caattgatgc     1740

agataagaga attacccctc taaaaactct taaccatcag tttgtgacaa tgactcacct     1800

tttggatttt ccacatagca atcatgttaa gtcttgtttt cagaacatgg agatctgcaa     1860

gcggagggtt cacatgtatg atacagtgag tcagatcaag agtcccttca ctacacatgt     1920

tgccccaaat acaagcacaa atctaaccat gagcttcagc aatcagctca atacagtgca     1980

caatcaggcc agtgttctag cttccagttc tactgcagca gctgctactc tttctctggc     2040

taattcagat gtctcactac taaactacca gtcagctttg tacccatcat ctgctgcacc     2100

agttcctgga gttgcccagc agggtgtttc cttgcagcct ggaaccaccc agatttgcac     2160

tcagacagat ccattccaac agacatttat agtatgtcca cctgcgtttc aaactggact     2220

acaagcaaca acaaagcatt ctggattccc tgtgaggatg gataatgctg taccgattgt     2280

accccaggca ccagctgctc agccactaca gattcagtca ggagttctca cgcagggaag     2340

ctgtacacca ctaatggtag caactctcca ccctcaagta gccaccatca caccgcagta     2400

tgcggtgccc tttactctga gctgcgcagc cggccggccg gcgctggttg aacagactgc     2460

cgctgtactg caggcgtggc ctggagggac tcagcaaatt ctcctgcctt caacttggca     2520

acagttgcct ggggtagctc tacacaactc tgtccagccc acagcaatga ttccagaggc     2580

catggggagt ggacagcagc tagctgactg gaggaatgcc cactctcatg gcaaccagta     2640

cagcactatc atgcagcagc catccttgct gactaaccat gtgacattgg ccactgctca     2700

gcctctgaat gttggtgttg cccatgttgt cagacaacaa caatccagtt ccctcccttc     2760

gaagaagaat aagcagtcag ctccagtctc ttccaagtcc tctctagatg ttctgccttc     2820

ccaagtctat tctctggttg ggagcagtcc cctccgcacc acatcttctt ataattcctt     2880

ggtccctgtc caagatcagc atcagcccat catcattcca gatactccca gccctcctgt     2940

gagtgtcatc actatccgaa gtgacactga tgaggaagag gacaacaaat acaagcccag     3000

tagctctgga ctgaagccaa ggtctaatgt catcagttat gtcactgtca atgattctcc     3060

agactctgac tcttctttga gcagccctta ttccactgat accctgagtg ctctccgagg     3120

caatagtgga tccgttttgg aggggcctgg cagagttgtg gcagatggca ctggcacccg     3180

cactatcatt gtgcctccac tgaaaactca gcttggtgac tgcactgtag caacccaggc     3240

ctcaggtctc ctgagcaata agactaagcc agtcgcttca gtgagtgggc agtcatctgg     3300

atgctgtatc acccccacag ggtatcgagc tcaacgcggg gggaccagtg cagcacaacc     3360

actcaatctt agccagaacc agcagtcatc ggcggctcca acctcacagg agagaagcag     3420

caacccagcc ccccgcaggc agcaggcgtt tgtggcccct ctctcccaag ccccctacac     3480

cttccagcat ggcagcccgc tacactcgac agggcaccca caccttgccc cggcccctgc     3540

tcacctgcca agccaggctc atctgtatac gtatgctgcc ccgacttctg ctgctgcact     3600

gggctcaacc agctccattg ctcatctttt ctccccacag ggttcctcaa ggcatgctgc     3660

agcctatacc actcacccta gcactttggt gcaccaggtc cctgtcagtg ttgggcccag     3720

cctcctcact tctgccagcg tggcccctgc tcagtaccaa caccagtttg ccacccaatc     3780

ctacattggg tcttcccgag gctcaacaat ttacactgga tacccgctga gtcctaccaa     3840

gatcagccag tattcctact tatagttggt gagcatgagg gaggaggaat catggctacc     3900

ttctcctggc cctgcgttct taatattggg ctatggagag atcctccttt accctcttga     3960

aatttcttag ccagcaactt gttctgcagg ggcccactga agcagaaggt ttttctctgg     4020

gggaacctgt ctcagtgttg actgcattgt tgtagtcttc ccaaagtttg ccctattttt     4080

aaattcatta tttttgtgac agtaattttg gtacttggaa gagttcagat gcccatcttc     4140

tgcagttacc aaggaagaga gattgttctg aagttaccct ctgaaaaata ttttgtctct     4200

ctgacttgat ttctataaat gcttttaaaa acaagtgaag cccctcttta tttcattttg     4260

tgttattgtg attgctggtc aggaaaaatg ctgatagaag gagttgaaat ctgatgacaa     4320

aaaaagaaaa attacttttt gtttgtttat aaactcagac ttgcctattt tattttaaaa     4380

gcggcttaca caatctccct tttgtttatt ggacatttaa acttacagag tttcagtttt     4440

gttttaatgt catattatac ttaatgggca attgttattt ttgcaaaact ggttacgtat     4500

tactctgtgt tactattgag attctctcaa ttgctcctgt gtttgttata aagtagtgtt     4560

taaaaggcag ctcaccattt gctggtaact taatgtgaga gaatccatat ctgcgtgaaa     4620

acaccaagta ttctttttaa atgaagcacc atgaattctt ttttaaatta ttttttaaaa     4680

gtctttctct ctctgattca gcttaaattt ttttatcgaa aaagccatta aggtggttat     4740

tattacatgg tggtggtggt tttattatat gcaaaatctc tgtctattat gagatactgg     4800

cattgatgag ctttgcctaa agattagtat gaattttcag taatacacct ctgttttgct     4860

catctctccc ttctgtttta tgtgatttgt ttggggagaa agctaaaaaa acctgaaacc     4920

agataagaac atttcttgtg tatagctttt atacttcaaa gtagcttcct ttgtatgcca     4980

gcagcaaatt gaatgctctc ttattaagac ttatataata agtgcatgta ggaattgcaa     5040

aaaatatttt aaaaatttat tactgaattt aaaaatattt tagaagtttt gtaatggtgg     5100

tgttttaata ttttacataa ttaaatatgt acatattgat tagaaaaata taacaagcaa     5160

tttttcctgc taacccaaaa tgttatttgt aatcaaatgt gtagtgatta cacttgaatt     5220

gtgtacttag tgtgtatgtg atcctccagt gttatcccgg agatggattg atgtctccat     5280

tgtatttaaa ccaaaatgaa ctgatacttg ttggaatgta tgtgaactaa ttgcaattat     5340

attagagcat attactgtag tgctgaatga gcaggggcat tgcctgcaag gagaggagac     5400

ccttggaatt gttttgcaca ggtgtgtctg gtgaggagtt tttcagtgtg tgtctcttcc     5460

ttccctttct tcctccttcc cttattgtag tgccttatat gataatgtag tggttaatag     5520

agtttacagt gagcttgcct taggatggac cagcaagccc ccgtggaccc taagttgttc     5580

accgggattt atcagaacag gattagtagc tgtattgtgt aatgcattgt tctcagtttc     5640

cctgccaaca ttgaaaaata aaaacagcag cttttctcct ttaccaccac ctctacccct     5700

ttccattttg gattctcggc tgagttctca cagaagcatt ttccccatgt ggctctctca     5760

ctgtgcgttg ctaccttgct tctgtgagaa ttcaggaagc aggtgagagg agtcaagcca     5820

atattaaata tgcattcttt taaagtatgt gcaatcactt ttagaatgaa tttttttttc     5880

cttttcccat gtggcagtcc ttcctgcaca tagttgacat tcctagtaaa atatttgctt     5940

gttgaaaaaa acatgttaac agatgtgttt ataccaaaga gcctgttgta ttgcttacca     6000

tgtccccata ctatgaggag aagttttgtg gtgccgctgg tgacaaggaa ctcacagaaa     6060

ggtttcttag ctggtgaaga atatagagaa ggaaccaaag cctgttgagt cattgaggct     6120

tttgaggttt cttttttaac agcttgtata gtcttggggc ccttcaagct gtgaaattgt     6180

ccttgtactc tcagctcctg catggatctg ggtcaagtag aaggtactgg ggatggggac     6240

attcctgccc ataaaggatt tggggaaaga agattaatcc taaaatacag gtgtgttcca     6300

tctgaattga aaatgatata tttgagatat aattttagga ctggttctgt gtagatagag     6360

atggtgtcaa ggaggtgcag gatggagatg ggagatttca tggagcctgg tcagccagct     6420

ctgtaccagg ttgaacaccg aggagctgtc aaagtatttg gagtttcttc attgtaagga     6480

gtaagggctt ccaagatggg gcaggtagtc cgtacagcct accaggaaca tgttgtgttt     6540

tctttatttt ttaaaatcat tatattgagt tgtgttttca gcactatatt ggtcaagata     6600

gccaagcagt ttgtataatt tctgtcacta gtgtcataca gttttctggt caacatgtgt     6660

gatctttgtg tctccttttt gccaagcaca ttctgatttt cttgttggaa cacaggtcta     6720

gtttctaaag gacaaatttt ttgttccttg tcttttttct gtaagggaca agatttgttg     6780

tttttgtaag aaatgagatg caggaaagaa aaccaaatcc cattcctgca ccccagtcca     6840

ataagcagat accacttaag ataggagtct aaactccaca gaaaaggata ataccaagag     6900

cttgtattgt taccttagtc acttgcctag cagtgtgtgg ctttaaaaac tagagatttt     6960

tcagtcttag tctgcaaact ggcatttccg attttccagc ataaaaatcc acctgtgtct     7020

gctgaatgtg tatgtatgtg ctcactgtgg ctttagattc tgtccctggg gttagccctg     7080

ttggccctga caggaaggga ggaagcctgg tgaatttagt gagcagctgg cctgggtcac     7140

agtgacctga cctcaaacca gcttaaggct ttaagtcctc tctcagaact tggcatttcc     7200

aacttcttcc tttccgggtg agagaagaag cggagaaggg ttcagtgtag ccactctggg     7260

ctcataggga cacttggtca ctccagagtt tttaatagct cccaggaggt gatattattt     7320

tcagtgctca gctgaaatac caaccccagg aataagaact ccatttcaaa cagttctggc     7380

cattctgagc ctgcttttgt gattgctcat ccattgtcct ccactagagg ggctaagctt     7440

gactgccctt agccaggcaa gcacagtaat gtgtgttttg ttcagcatta ttatgcaaaa     7500

attcactagt tgagatggtt tgttttagga taggaaatga aattgcctct cagtgacagg     7560

agtggcccga gcctgcttcc tattttgatt tttttttttt ttaactgata gatggtgcag     7620

catgtctaca tggttgtttg ttgctaaact ttatataatg tgtggtttca attcagcttg     7680

aaaaataatc tcactacatg tagcagtaca ttatatgtac attatatgta atgttagtat     7740

ttctgctttg aatccttgat attgcaatgg aattcctact ttattaaatg tatttgatat     7800

gctagttatt gtgtgcgatt taaacttttt ttgctttctc cctttttttg gttgtgcgct     7860

ttcttttaca acaagcctct agaaacagat agtttctgag aattactgag ctatgtttgt     7920

aatgcagatg tacttaggga gtatgtaaaa taatcatttt aacaaaagaa atagatattt     7980

aaaatttaat actaactatg ggaaaagggt ccattgtgta aaacatagtt tatctttgga     8040

ttcaatgttt gtctttggtt ttacaaagta gcttgtattt tcagtatttt ctacataata     8100

tggtaaaatg tagagcaatt gcaatgcatc aataaaatgg gtaaattttc tgactta        8157


<210> 1708
<211> 3424
<212> DNA
<213> Homo sapiens

<400> 1708
gcagagtctg cagtgcggag ggggcgggaa gtccaggccc cgcactcgat ccacgctggc       60

tccctacgga ggcccaccta ctcgaggccc accgactcct actgcaatca gtactatgcg      120

atcgtcctag agagtccatt cagctgcact tccgcctcag tatggcatca cagctgcaag      180

tgttttcgcc cccatcagtg tcgtcgagtg ccttctgcag tgcgaagaaa ctgaaaatag      240

agccctctgg ctgggatgtt tcaggacaga gtagcaacga caaatattat acccacagca      300

aaaccctccc agccacacaa gggcaagcca actcctctca ccaggtagca aatttcaaca      360

tccctgctta cgaccagggc ctcctcctcc cagctcctgc agtggagcat attgttgtaa      420

cagccgctga tagctcgggc agtgctgcta catcaacctt ccaaagcagc cagaccctga      480

ctcacagaag caacgtttct ttgcttgagc catatcaaaa atgtggattg aaacgaaaaa      540

gtgaggaagt tgacagcaac ggtagtgtgc agatcataga agaacatccc cctctcatgc      600

tgcaaaacag gactgtggtg ggtgctgctg ccacaaccac cactgtgacc acaaagagta      660

gcagttccag cggagaaggg gattaccagc tggtccagca tgagatcctt tgctctatga      720

ccaatagcta tgaagtcttg gagttcctag gccgggggac atttggacag gtggctaagt      780

gctggaagag gagcaccaag gaaattgtgg ctattaaaat cttgaagaac cacccctcct      840

atgccagaca aggacagatt gaagtgagca tcctttcccg cctaagcagt gaaaatgctg      900

atgagtataa ttttgtccgt tcatacgagt gctttcagca taagaatcac acctgccttg      960

tttttgaaat gttggagcag aacttatatg attttctaaa gcaaaacaaa tttagcccac     1020

tgccactcaa gtacatcaga ccaatcttgc agcaggtggc cacagccttg atgaagctca     1080

agagtcttgg tctgatccac gctgacctta agcctgaaaa catcatgctg gttgatccag     1140

ttcgccagcc ctaccgagtg aaggtcattg actttggttc tgctagtcac gtttccaaag     1200

ctgtgtgctc aacctactta cagtcacgtt actacagagc tcctgaaatt attcttgggt     1260

taccattttg tgaagctatt gatatgtggt cactgggctg tgtgatagct gagctgttcc     1320

tgggatggcc tctttatcct ggtgcttcag aatatgatca gattcgttat atttcacaaa     1380

cacaaggctt gccagctgaa tatcttctca gtgccggaac aaaaacaacc aggtttttca     1440

acagagatcc taatttgggg tacccactgt ggaggcttaa gacacctgaa gaacatgaac     1500

tggagactgg aataaaatca aaagaagctc ggaagtacat ttttaattgc ttagatgaca     1560

tggctcaggt gaatatgtct acagacctgg agggaacaga catgttggca gagaaggcag     1620

accgaagaga atacattgat ctgttaaaga aaatgctcac aattgatgca gataagagaa     1680

ttacccctct aaaaactctt aaccatcagt ttgtgacaat gactcacctt ttggattttc     1740

cacatagcaa tcatgttaag tcttgttttc agaacatgga gatctgcaag cggagggttc     1800

acatgtatga tacagtgagt cagatcaaga gtcccttcac tacacatgtt gccccaaata     1860

caagcacaaa tctaaccatg agcttcagca atcagctcaa tacagtgcac aatcaggcca     1920

gtgttctagc ttccagttct actgcagcag ctgctactct ttctctggct aattcagatg     1980

tctcactact aaactaccag tcagctttgt acccatcatc tgctgcacca gttcctggag     2040

ttgcccagca gggtgtttcc ttgcagcctg gaaccaccca gatttgcact cagacagatc     2100

cattccaaca gacatttata gtatgtccac ctgcgtttca aactggacta caagcaacaa     2160

caaagcattc tggattccct gtgaggatgg ataatgctgt accgattgta ccccaggcac     2220

cagctgctca gccactacag attcagtcag gagttctcac gcagggaagc tgtacaccac     2280

taatggtagc aactctccac cctcaagtag ccaccatcac accgcagtat gcggtgccct     2340

ttactctgag ctgcgcagcc ggccggccgg cgctggttga acagactgcc gctgtactgc     2400

aggcgtggcc tggagggact cagcaaattc tcctgccttc aacttggcaa cagttgcctg     2460

gggtagctct acacaactct gtccagccca cagcaatgat tccagaggcc atggggagtg     2520

gacagcagct agctgactgg aggaatgccc actctcatgg caaccagtac agcactatca     2580

tgcagcagcc atccttgctg actaaccatg tgacattggc cactgctcag cctctgaatg     2640

ttggtgttgc ccatgttgtc agacaacaac aatccagttc cctcccttcg aagaagaata     2700

agcagtcagc tccagtctct tccaagtcct ctctagatgt tctgccttcc caagtctatt     2760

ctctggttgg gagcagtccc ctccgcacca catcttctta taattccttg gtccctgtcc     2820

aagatcagca tcagcccatc atcattccag atactcccag ccctcctgtg agtgtcatca     2880

ctatccgaag tgacactgat gaggaagagg acaacaaata caagcccagt agctctggac     2940

tgaagccaag gtctaatgtc atcagttatg tcactgtcaa tgattctcca gactctgact     3000

cttctttgag cagcccttat tccactgata ccctgagtgc tctccgaggc aatagtggat     3060

ccgttttgga ggggcctggc agagttgtgg cagatggcac tggcacccgc actatcattg     3120

tgcctccact gaaaactcag cttggtgact gcactgtagc aacccaggcc tcaggtctcc     3180

tgagcaataa gactaagcca gtcgcttcag tgagtgggca gtcatctgga tgctgtatca     3240

cccccacagg gtatcgagct caacgcgggg ggaccagtgc agcacaacca ctcaatctta     3300

gccaggtaag tgctatgggc tactgccttc tgtttgggcc ctgcactgtt gttactttct     3360

ggagaaccct gcttctggct ggatgctgaa taaagccaaa tgaagcccct tttgtgtcaa     3420

acaa                                                                  3424


<210> 1709
<211> 748
<212> DNA
<213> Homo sapiens

<400> 1709
atcctcgtgg gccctgacct tctctctgag agccgggcag aggctccgga gccatgcagg       60

ccgaaggcca gggcacaggg ggttcgacgg gcgatgctga tggcccagga ggccctggca      120

ttcctgatgg cccagggggc aatgctggcg gcccaggaga ggcgggtgcc acgggcggca      180

gaggtccccg gggcgcaggg gcagcaaggg cctcggggcc gagaggaggc gccccgcggg      240

gtccgcatgg cggtgccgct tctgcgcagg atggaaggtg cccctgcggg gccaggaggc      300

cggacagccg cctgcttcag ttgcacatca cgatgccttt ctcgtcgccc atggaagcgg      360

agctggtccg caggatcctg tcccgggatg ccgcacctct cccccgacca ggggcggttc      420

tgaaggactt caccgtgtcc ggcaacctac tgtttatccg actgactgct gcagaccacc      480

gccaactgca gctctccatc agctcctgtc tccagcagct ttccctgttg atgtggatca      540

cgcagtgctt tctgcccgtg tttttggctc aggctccctc agggcagagg cgctaagccc      600

agcctggcgc cccttcctag gtcatgcctc ctcccctagg gaatggtccc agcacgagtg      660

gccagttcat tgtgggggcc tgattgtttg tcgctggagg aggacggctt acatgtttgt      720

ttctgtagaa aataaagctg agctacga                                         748


<210> 1710
<211> 1110
<212> DNA
<213> Homo sapiens

<400> 1710
tcccgaggtg aagcggaggc ccaaggctga ggagcccgcc tcgccggaga cgcccaggcg       60

ctggccctgg atcccggagc cacggccgtc tctcagccag agctgagcct cggcggcccg      120

gccggcgctg gcctccgtgc ggcggcggca aacacggccc gcaggggacc gggtcgggtg      180

gggctgggcg ccgcgcggct ccctgtggag cctgcctgtt ggagcgcggc ggggctccgg      240

cggtggtctt ggagctggcg tgtggatttc cacgtccgaa tgatcgagtt gtggcgggct      300

ttgagatgtc agaggattta gcaaagcagc tggcaagcta caaagctcag ctccagcaag      360

ttgaagctgc attatctgga aatggagaaa atgaagattt gctaaaattg aagaaagatt      420

tacaagaagt tatagaacta accaaagacc ttctgtcaac tcaaccttct gagacgcttg      480

caagttcaga cagttttgct tctactcaac ctactcattc atggaaagta ggagacaagt      540

gtatggcagt ctggagtgaa gatggacagt gttatgaagc ggagattgag gagatagatg      600

aagaaaatgg caccgctgca atcacctttg ctggttatgg caatgctgaa gtgactccac      660

tgttgaacct caagcctgta gaagaaggaa ggaaggcaaa ggaggacagt ggcaacaaac      720

ccatgtcaaa aaaagaaatg attgcccagc agcgtgaata taaaaagaag aaagctttga      780

aaaaagctca gagaataaaa gaacttgagc aggaaagaga ggaccagaaa gtgaaatggc      840

aacaattcaa caacagagcc tattctaaaa acaaaaaagg ccaggtaaag aggagtattt      900

ttgcttcacc tgagagtgtg actggtaaag ttggagtagg aacctgtgga attgctgata      960

aacctatgac acaatatcaa gatacctcta aatacaatgt caggcatttg atgcctcaat     1020

aatcagaaaa actgttggat ttcatctctg cagggcttta catttacctt tttatcctta     1080

tatttttcta aaggtaaatt atttgttaga                                      1110


<210> 1711
<211> 2031
<212> DNA
<213> Homo sapiens

<400> 1711
tctctgtctt ttcctccttc cagtgcccgg cgttcctccc ttccccctcg ccgccgaccg       60

agttcttcct tttcagaccg ggtcgccttg ctgtcgtcgc ggtgattttc ctgctactgc      120

tactgctgct gctgccaccg ccactaccac tgggctcatt tgccccgacc ccttcccgcc      180

gccccgcccc cagccccaca caagatgtca gaggatttag caaagcagct ggcaagctac      240

aaagctcagc tccagcaagt tgaagctgca ttatctggaa atggagaaaa tgaagatttg      300

ctaaaattga agaaagattt acaagaagtt atagaactaa ccaaagacct tctgtcaact      360

caaccttctg agacgcttgc aagttcagac agttttgctt ctactcaacc tactcattca      420

tggaaagtag gagacaagtg tatggcagtc tggagtgaag atggacagtg ttatgaagcg      480

gagattgagg agatagatga agaaaatggc accgctgcaa tcacctttgc tggttatggc      540

aatgctgaag tgactccact gttgaacctc aagcctgtag aagaaggaag gaaggcaaag      600

gaggacagtg gcaacaaacc catgtcaaaa aaagaaatga ttgcccagca gcgtgaatat      660

aaaaagaaga aagctttgaa aaaagctcag agaataaaag aacttgagca ggaaagagag      720

gaccagaaag tgaaatggca acaattcaac aacagagcct attctaaaaa caaaaaaggc      780

caggtaaaga ggagtatttt tgcttcacct gagagtgtga ctggtaaagt tggagtagga      840

acctgtggaa ttgctgataa acctatgaca caatatcaag atacctctaa atacaatgtc      900

aggcatttga tgcctcaata atcagaaaaa ctgttggatt tcatctctgc agggctttac      960

atttaccttt ttatccttat atttttctaa aggtaaatta tttgttagat gagtaagcaa     1020

gataccattg tcgtcattgg ttggcttcag tagaatgaaa cgtgaagaaa ttgcatttga     1080

taactgctat tcatttaact tttctcatta tcagtaccac ggttccctca aagtttgttg     1140

aataaagcaa cttttgtaga tgctgtttca tacagcactt agatgaatta ttgatcttcc     1200

taatatcagg cgcctactta acctatggtg tgtacttttt gtaagttgta acttgaaatt     1260

ttcagatgct ttgaacttga cacatactct agcaattcat tggaacacca aggcaaaaac     1320

accaacctgc taaaagagat cttttcattt ttcttatttt cagctttaaa acttagctgt     1380

cgttcagtta agcttaaaga taggttaatt tgtaaatggc aaagtttgtt ttgaggtttt     1440

tcctcaataa cttgtttccc aggcctatta ggccatctct aaaattgatc tagctgtttt     1500

atttttatgt actcttagtt ttatgtaaga aaccttagga tgagctccct tttctaaggt     1560

gtttttgttt tttgtatgtt tgcttttttc ctgttttttg ttttttccat ttacggcagt     1620

ggtaccatgt tttggatgtg tgatgtttat atgggagaac aaaaagctga tgtatagccc     1680

tgtatacagt gtagatacta tttttgtaaa aacacaaggc taaattaatg aacaagaata     1740

ctgaatattt catcattaaa aatttcttgt atttcttgtg cattaatctg acgataattt     1800

ccctgtatat tatgttcatt tagctgtttg taatttttgt taattagatc aggttgtctg     1860

catttgttgg tgtaagtgaa catcatcaca gttatcctga gttgagttta agccaaatac     1920

atgcatagaa aagggtcttc ctattaatgg aagaaggtaa tttttaggat gtgtattatt     1980

tcagttttgt atgtttaact tttattaaat aaagtgtttt taaaatctcc a              2031


<210> 1712
<211> 2377
<212> DNA
<213> Homo sapiens

<400> 1712
gacctcagca gtgggggagg aatagaacct cagtgtagtt ctgaggtgta cttcagggcc       60

agggagagag gatgtgaaaa tgtggcctgg tctcttgggc tgcgttcaca ttgctttctg      120

gaagctgagc tccatcccct cccttggttt ttgccaacta atgtgtgctc tcccttacca      180

ggtgctgccc ataaactcgt gtgttatttc accaactggg cacacagtcg gccaggccct      240

gcctcgatct tgccccatga cctggacccc tttctctgca cccacctgat atttgccttt      300

gcctcaatga acaacaatca gattgttgct aaggatctcc aggatgagaa aattctctac      360

ccagagttca acaaactaaa ggagagaatg tggcagcagc tgcccaccgg agtgaagaac      420

ccagctcatc aaccctctct ctcacatcat aggaacagag agctgaaaac actactgtcc      480

atcggcgggt ggaactttgg cacctcaaga ttcaccacta tgttgtccac atttgccaac      540

cgtgaaaagt ttattgcttc agttatatcc cttctgagga cacatgactt tgatggtctt      600

gaccttttct tcttatatcc tggactaaga ggcagcccca tgcatgaccg gtggactttt      660

ctcttcttaa ttgaagagct cctgtttgcc ttccggaagg aggcactgct caccatgcgc      720

ccgaggctgc tgctgtctgc tgctgtttct ggggtcccac acatcgtcca aacatcctat      780

gatgtgcgct ttctaggaag actcctggat ttcatcaatg tcttgtctta tgacttacat      840

ggaagttggg aaaggttcac aggacataat agccccctct tctctctgcc tgaagacccc      900

aaatcttcgg catatgctat gaattattgg agaaagcttg gggcaccctc agagaagctc      960

atcatgggga tccccaccta tggacgtacc tttcgcctcc tcaaagcctc taagaatggg     1020

ttgcaggcca gagcgatcgg accagcatct ccagggaagt acaccaagca agaaggcttc     1080

ttggcttatt ttgagatttg ttcctttgtc tggggagcga agaagcactg gattgattac     1140

cagtatgtcc cgtatgccaa caaggggaaa gagtgggttg gctatgacaa tgccatcagc     1200

ttcagttaca aggcatggtt tataaggcga gagcattttg ggggggccat ggtgtggaca     1260

ttggacatgg atgacgtcag gggcacgttc tgtggcactg gccctttccc ccttgtctac     1320

gtattgaatg atatcctggt gcgggctgag ttcagttcaa cttctttacc acaattttgg     1380

ctgtcatctg ctgtgaattc ttcaagcact gaccctgaaa ggctggctgt gaccacggca     1440

tggaccactg atagtaagat tttgccccca ggaggagagg ctggggtcac tgagatccac     1500

ggaaagtgtg aaaatatgac tataacccct agaggtacaa ctgtgacccc tacaaaggaa     1560

actgtatccc ttggaaagca cactgtagct ctaggagaga agactgagat cactggggca     1620

atgaccatga cttctgtggg tcatcagtcc atgacccctg gagagaaggc cctgacccct     1680

gtgggtcatc aatctgtgac cactggacag aagaccctga cctctgtggg ttatcagtct     1740

gtgacccctg gggaaaagac cctgacccct gtgggtcatc agtctgtgac ccctgtgagt     1800

catcagtctg tgagccctgg aggaacgact atgacccctg tccattttca gactgagacc     1860

cttagacaga atacagtggc ccctagaagg aaggctgtgg cccgtgaaaa ggtgactgtc     1920

ccctccagaa acatatcagt cacccctgaa gggcagacta tgcctttaag aggggagaat     1980

ttgacttctg aggtgggcac tcaccccagg atgggtaact tgggtcttca gatggaagct     2040

gaaaacagga tgatgctgtc ctccagcccc gtcatccagc tcccggaaca aactcctcta     2100

gcttttgaca accgctttgt tcccatctat ggaaaccatt cctctgtcaa ctcagtaacc     2160

cctcaaacaa gtcctctttc tctaaaaaaa gaaatcccag aaaactctgc tgtggatgaa     2220

gaagcctaag cccctctggt gtcagaaacc agggaaaacc cttgtctttt cttctaagtg     2280

acatgttgga agccttctca tcccggggca aagcaggcat caaaaccaga ataggccaat     2340

ctcttttcca ttaaataaac tgtaaacaca agaaccc                              2377


<210> 1713
<211> 2243
<212> DNA
<213> Homo sapiens

<400> 1713
agggaagctc ctataaaggg ctgcatctct ggactcacag ctatcagacc attgagatgt       60

ggaagctgtt gctgtgggtt gggctggttc ttgtgctgaa acaccacgat ggtgctgccc      120

ataaactcgt gtgttatttc accaactggg cacacagtcg gccaggccct gcctcgatct      180

tgccccatga cctggacccc tttctctgca cccacctgat atttgccttt gcctcaatga      240

acaacaatca gattgttgct aaggatctcc aggatgagaa aattctctac ccagagttca      300

acaaactaaa ggagaggaac agagagctga aaacactact gtccatcggc gggtggaact      360

ttggcacctc aagattcacc actatgttgt ccacatttgc caaccgtgaa aagtttattg      420

cttcagttat atcccttctg aggacacatg actttgatgg tcttgacctt ttcttcttat      480

atcctggact aagaggcagc cccatgcatg accggtggac ttttctcttc ttaattgaag      540

agctcctgtt tgccttccgg aaggaggcac tgctcaccat gcgcccgagg ctgctgctgt      600

ctgctgctgt ttctggggtc ccacacatcg tccaaacatc ctatgatgtg cgctttctag      660

gaagactcct ggatttcatc aatgtcttgt cttatgactt acatggaagt tgggaaaggt      720

tcacaggaca taatagcccc ctcttctctc tgcctgaaga ccccaaatct tcggcatatg      780

ctatgaatta ttggagaaag cttggggcac cctcagagaa gctcatcatg gggatcccca      840

cctatggacg tacctttcgc ctcctcaaag cctctaagaa tgggttgcag gccagagcga      900

tcggaccagc atctccaggg aagtacacca agcaagaagg cttcttggct tattttgaga      960

tttgttcctt tgtctgggga gcgaagaagc actggattga ttaccagtat gtcccgtatg     1020

ccaacaaggg gaaagagtgg gttggctatg acaatgccat cagcttcagt tacaaggcat     1080

ggtttataag gcgagagcat tttggggggg ccatggtgtg gacattggac atggatgacg     1140

tcaggggcac gttctgtggc actggccctt tcccccttgt ctacgtattg aatgatatcc     1200

tggtgcgggc tgagttcagt tcaacttctt taccacaatt ttggctgtca tctgctgtga     1260

attcttcaag cactgaccct gaaaggctgg ctgtgaccac ggcatggacc actgatagta     1320

agattttgcc cccaggagga gaggctgggg tcactgagat ccacggaaag tgtgaaaata     1380

tgactataac ccctagaggt acaactgtga cccctacaaa ggaaactgta tcccttggaa     1440

agcacactgt agctctagga gagaagactg agatcactgg ggcaatgacc atgacttctg     1500

tgggtcatca gtccatgacc cctggagaga aggccctgac ccctgtgggt catcaatctg     1560

tgaccactgg acagaagacc ctgacctctg tgggttatca gtctgtgacc cctggggaaa     1620

agaccctgac ccctgtgggt catcagtctg tgacccctgt gagtcatcag tctgtgagcc     1680

ctggaggaac gactatgacc cctgtccatt ttcagactga gacccttaga cagaatacag     1740

tggcccctag aaggaaggct gtggcccgtg aaaaggtgac tgtcccctcc agaaacatat     1800

cagtcacccc tgaagggcag actatgcctt taagagggga gaatttgact tctgaggtgg     1860

gcactcaccc caggatgggt aacttgggtc ttcagatgga agctgaaaac aggatgatgc     1920

tgtcctccag ccccgtcatc cagctcccgg aacaaactcc tctagctttt gacaaccgct     1980

ttgttcccat ctatggaaac cattcctctg tcaactcagt aacccctcaa acaagtcctc     2040

tttctctaaa aaaagaaatc ccagaaaact ctgctgtgga tgaagaagcc taagcccctc     2100

tggtgtcaga aaccagggaa aacccttgtc ttttcttcta agtgacatgt tggaagcctt     2160

ctcatcccgg ggcaaagcag gcatcaaaac cagaataggc caatctcttt tccattaaat     2220

aaactgtaaa cacaagaacc cac                                             2243


<210> 1714
<211> 3830
<212> DNA
<213> Homo sapiens

<400> 1714
gcagtcaggc cgttgtgcgc aggcgcagag gcggcggcgg cggcggcggc ggcggatgtt       60

tacggcggcc gaggttggag cggcgctgct cggccgcgga cacacgaggg acgcgcccga      120

ggagctgcag gtggcagccc aggcggtccg aacccgtcgg ccggccgagc ctggagtatt      180

gcctaagtgt aatcttgaac atgggcggtg ctgtgagtgc tggtgaagac aatgatgagc      240

tgatagataa tttgaaagaa gcacagtata tccggactga gctggtagag caggctttca      300

gagctatcga tcgtgcagac tattatcttg aagaatttaa agaaaatgct tataaagact      360

tggcatggaa gcatggaaac attcacctct cagccccgtg catctactcg gaggtgatgg      420

aagccctaga tctgcagcct ggactctcgt ttctgaacct gggcagtggc actgggtatc      480

tcagctccat ggtgggcctc attctaggtc cttttggtgt gaaccatggg gtggaacttc      540

actcagatgt gatagagtat gcaaagcaga aactggactt cttcatcaga acaagtgata      600

gttttgacaa gtttgacttc tgtgaacctt cctttgttac tgggaattgc ctggagattt      660

ctccggattg ttctcagtat gatcgtgtat actgtggggc tggcgtgcag aaagagcatg      720

aagagtacat gaagaatctt ctcaaagtgg gagggatcct tgtcatgcca ctggaagaga      780

agccctgcca ttcagagtca ggaaaatcaa gacttgtcca gttaccacca gtggcagttc      840

gcagcctcca ggacttggct cgcatcgcca tccggggcac cattaaaaag attattcatc      900

aggaaactgt gagcaaaaac ggaaacggac taaagaacac ccccaggttt aaacgaagga      960

gagttcgccg ccgtcgaatg gaaacgattg tctttttgga caaagaagtc tttgccagtc     1020

ggatttccaa cccctcagat gacaacagct gtgaagactt ggaagaggaa cggagggaag     1080

aagaagagaa gaccccgccg gaaacaaagc cagacccccc agtgaacttc ctacgccaga     1140

aggtcctgag cctccctctg ccagatcccc tgaaatacta cttgctttat tacagagaaa     1200

aataagtctc ctgtttgaaa gggggaaata ggaagagcag attgctgagt gtgaagttcg     1260

tgctgcctgt gtgctgttga agggtcacct ggaggcagac gttgtgggga agggaactgc     1320

tgggctcatc cacaccatgg ttttcttcta gttcctgatt gacctctaaa attctattca     1380

gttgtatgat ttgtttacat agttccacaa gaccttcatt gcatagaaga ttgttttccc     1440

aaagtggaga gaatcttcat agagaaaaag agaaggctgt ttctttttcg gctctgacga     1500

aacactgaag tctgcgtaag agagactgtt tgatgaccgt ccctcatgca acatgcacgg     1560

tactcactaa aaatgaaaac tgaagtggaa actaacctgt gttgcttata aagtgtgaaa     1620

gcacaagctt ataaatgtat aaaatctttt ctgggtgtga cgcacctgcg tccaagtttg     1680

aatttttatg atatgtacca cttaattact ggcactgagt atcactgaat ttcttagttt     1740

tctagtgggg aaacattatt gagaagccct cccttatttt aagtaagttg attaaatctt     1800

atgtgagttg ccagttgtaa tttttcaaag gaaaaatttt gatggggtgg aggaatgaat     1860

tgccagataa tctttctgga attccgagag aattccaaag agggtttttt tttttttttt     1920

taggacatct tttgatacct ttaaaagaac cactgtcaag taatccttaa aagaatatct     1980

tggaaaagga aacagatttt ttcctgtgtg taagcaataa gtgaagttac atttgcccta     2040

accctaggga tgattcttta cccagtttta aagcccatca tggtattcta aggtgttgac     2100

accctccatc ctcagagcag gtcgaaaata ttaaatagac tggggactct atgatgggca     2160

gcctgtgctt tttgacttca gtttgctatt tttctgtgat cacattagta ctgattcata     2220

gattctatct tttataattc tggagaaaaa gatttgttag ttttgtaatt tttttgtaag     2280

accaaatgta tgtattttag tagctccatt gcatgagaag agtgtaactc acactgactt     2340

gtgatatcag ccttctctgg gccttgtgtg tggagagctt tctatcttac caagtggtag     2400

ggctaaaaga acaacagcct ttttggtagt cacatagcag aatgatcaga gttacattgc     2460

ttattccaaa acattggttc tttttaaaac attttttttt acccaaagaa aagaataata     2520

gaaattacta acaataaata taaattcaga gtgttgatat aggattcagt atccagagtt     2580

tatttttaat cttaatcctc agcttcttgg gagttgctgg gcttcagtgt ctctgtggtt     2640

tcaccagctt agcttgagct ctggttattt tggatctttt ctgctttttt taagtaactg     2700

agtcattttt accacacagt ccagtttgca tgtatagcta ggaaacatgt attgctctag     2760

attgggcagt ttaagtcatt ttaaagaaag ttagttcata gttgttgcct tttaactcat     2820

agtcaagctt cagtctttca aagagaaatg tgtgattttc atttacttgc tgatattttg     2880

tagtttggag atccttgtgg gcattattct aactgatacg tagacactta cttggaaatt     2940

tttggacatt atattaaatg agtgctatct gtgaaattgg ttatattagg tggcttgact     3000

aatgtttttt ctataattgt atatggactg catttttaaa aaaaccgcat ttgcctttat     3060

gctagattgt aaaaaattat attagaatgc ataagacatg tttttccttc atatgctaga     3120

cttttcctag catttcgtat ttctgtgttg tcagtgtgtg atttttaaac cggaatttgg     3180

tttaaaaaaa atctggtggt aatatatgtg agaaatactt tggtgtttac cttatgaaaa     3240

taaaggattg taagtaaagt ttcctgcgca ccttatacca gaattcagta taatacacta     3300

ctttctgttt tcaaacagat aaatcataat atagtctgta ttatctgtaa gatctgtctt     3360

gtaaaccaca ttcttgacaa ctatttgctt ttgagtagtt tgtattttaa tatgtgactt     3420

ttgtcttgaa aagtagtaaa gccatagact tgtgcaaaac aagtttcaag tttatagata     3480

ttaagtttgt aatgtgagca tcaaatgtgt atgtaaaaat actttttacc agtctggaac     3540

ttgggaaaat ccagggaatt tgaaacatag attttaatga gctggtaaac acaaatcatg     3600

tcaataaagg tagtcaggat attttatcct tagcattgct tctgcatcct gtgtaggatt     3660

ccaattcttg aatatgttct tttcaaaatc ttaagaaaag aacctttttt ctttattaac     3720

atcatgtgtt tactttcagc aaatatttgt attactgctt gattctgtga cagtcacaat     3780

agatgtagag aaggcattat ttttcattaa taaatgtgaa attggaatgg                3830


<210> 1715
<211> 2325
<212> DNA
<213> Homo sapiens

<400> 1715
gttgagcggt tagtgaccag gaagcctccc cacccaccag agtccaaaga gcacaggcgt       60

ggctgcctct gtaacctcat caaaggcagg ctctgcctgt ggccactagc agagaagctg      120

ctgtccttcc accaccagca ccggaccacc tgctccaaga ccagcctcct ggggggacca      180

ggcacccggc cttcactggc acccagggag ccgtcctcag cagcgtcaac atgtcaaggc      240

ccagcagcag agccatttac ttgcaccgga aggagtactc ccagaacctc acctcagagc      300

ccaccctcct gcagcacagg gtggagcact tgatgacatg caagcagggg agtcagagag      360

tccaggggcc cgaggatgcc ttgcagaagc tgttcgagat ggatgcacag ggccgggtgt      420

ggagccaaga cttgatcctg caggtcaggg acggctggct gcagctgctg gacattgaga      480

ccaaggagga gctggactct taccgcctag acagcatcca ggccatgaat gtggcgctca      540

acacatgttc ctacaactcc atcctgtcca tcaccgtgca ggagccgggc ctgccaggca      600

ctagcactct gctcttccag tgccaggaag tgggggcaga gcgactgaag accagcctgc      660

agaaggctct ggaggaagag ctggagcaaa gcagacctcg acttggaggc cttcagccag      720

gccaggacag atggaggggg cctgctatgg aaaggccgct ccctatggag caggcacgct      780

atctggagcc ggggatccct ccagaacagc cccaccagag gaccctagag cacagcctcc      840

caccatcccc aaggcccctg ccacgccaca ccagtgcccg agaaccaagt gcctttactc      900

tgcctcctcc aaggcggtcc tcttcccccg aggacccaga gagggacgag gaagtgctga      960

accatgtcct aagggacatt gagctgttca tgggaaagct ggagaaggcc caggcaaaga     1020

ccagcaggaa gaagaaattt gggaaaaaaa acaaggacca gggaggtctc acccaggcac     1080

agtacattga ctgcttccag aagatcaagc acagcttcaa cctcctggga aggctggcca     1140

cctggctgaa ggagacaagt gcccctgagc tcgtacacat cctcttcaag tccctgaact     1200

tcatcctggc caggtgccct gaggctggcc tagcagccca agtgatctca cccctcctca     1260

cccctaaagc tatcaacctg ctacagtcct gtctaagccc acctgagagt aacctttgga     1320

tggggttggg cccagcctgg accactagcc gggccgactg gacaggcgat gagcccctgc     1380

cctaccaacc cacattctca gatgactggc aacttccaga gccctccagc caagcaccct     1440

taggatacca ggaccctgtt tcccttcggc ggggaagtca taggttaggg agcacctcac     1500

actttcctca ggagaagaca cacaaccatg accctcagcc tggggacccc aactccaggc     1560

cctccagccc caaacctgcc cagccagccc tgaaaatgca agtcttgtac gagtttgaag     1620

ctaggaaccc acgggaactg actgtggtcc agggagagaa gctggaggtt ctggaccaca     1680

gcaagcggtg gtggctggtg aagaatgagg cgggacggag cggctacatt ccaagcaaca     1740

tcctggagcc cctacagccg gggacccctg ggacccaggg ccagtcaccc tctcgggttc     1800

caatgcttcg acttagctcg aggcctgaag aggtcacaga ctggctgcag gcagagaact     1860

tctccactgc cacggtgagg acacttgggt ccctgacggg gagccagcta cttcgcataa     1920

gacctgggga gctacagatg ctatgtccac aggaggcccc acgaatcctg tcccggctgg     1980

aggctgtcag aaggatgctg gggataagcc cttaggcacc agcttagaca cctccaagaa     2040

ccaggccccg ctgatgcaag atggcagatc tgatacccat tagagccccg agaattcctc     2100

ttctggatcc cagtttgcag caaaccccac accccagctc acacagcaaa aacaatggac     2160

aggcccagag gctgaagcaa acagtgtccc ttctggctgt gttggagcct ccccagtaac     2220

cacctattta ttttacctct ttcccaaacc tggagcattt atgcctaggc ttgtcaagaa     2280

tctgttcagt ccctctcctt ctcaataaaa gcatcttcaa gcttg                     2325


<210> 1716
<211> 3231
<212> DNA
<213> Homo sapiens

<400> 1716
cttctgtagc tcgcgttgaa gccgcacgtc cggccccgat cccggcacca tgagcttcgg       60

ctcggagcac tacctgtgct cctcctcctc ctaccgcaag gtgttcgggg atggctctcg      120

cctgtccgcc cgcctctctg gggccggcgg cgcgggcggc ttccgctcgc agtcgctgtc      180

ccgcagcaat gtggcctcct cggccgcctg ctcctcggcc tcgtcgctcg gcctcggcct      240

ggcctatcgc cggccgccgg cgtccgacgg gctggacctg agccaggcgg cggcgcgcac      300

caacgagtac aagatcatcc gcaccaacga gaaggagcag ctgcagggcc tcaacgaccg      360

cttcgccgtg ttcatcgaga aggtgcatca gctggagacg cagaaccgcg cgttggaggc      420

cgagctggcc gcgctgcgac agcgccacgc tgagccgtcg cgcgtcggcg agctcttcca      480

gcgcgagctg cgcgacctgc gcgcgcagct ggaggaggcc agctcggctc gctcgcaggc      540

cctgctggag cgcgacgggc tggcggagga ggtgcagcgg ctgcgggcgc gctgcgagga      600

ggagagccgc ggacgcgaag gcgccgagcg cgccctgaag gcgcagcagc gcgacgtgga      660

cggcgccacg ctggcccgcc tggacctgga gaagaaggtg gagtcgctgc tggacgagct      720

ggccttcgta cgccaggtgc acgacgagga ggtagccgag ctgctggcca cgctgcaggc      780

gtcgtcgcag gccgcggccg aggtggacgt gactgtggct aaaccagacc tgacctcggc      840

tctgagggag atccgcgccc agtatgagtc cctggccgct aagaacctgc agtccgcgga      900

agaatggtac aagtccaagt ttgccaacct gaacgagcag gcggcgcgca gcaccgaggc      960

catccgggcc agccgcgagg agatccacga gtatcggcgc cagctgcagg cgcgcaccat     1020

cgagatcgag ggcctgcgcg gggccaacga gtccttggag aggcagatcc tggagctgga     1080

ggagcggcac agtgccgagg tagctggcta ccaggatagc attgggcagc tggagaatga     1140

tctgaggaac accaagagtg agatggcacg ccaccttcgg gaataccagg acttgctcaa     1200

tgtcaaaatg gctcttgaca ttgagatagc agcttacagg aaactgctgg aaggcgagga     1260

gacacgtttt agcaccagtg ggttaagcat ttcggggctg aatccacttc ccaatccaag     1320

ttacctgctc ccacctagaa tcctcagtgc tacaacctcc aaagtctcat ccactgggct     1380

atcacttaag aaagaggagg aggaggagga ggcatctaag gtagcctcta agaaaacctc     1440

ccagataggg gaaagttttg aagaaatatt agaggagaca gtaatatcta ctaagaaaac     1500

cgagaaatca aatatagaag aaaccaccat ttcaagccaa aaaatataat tccattgctt     1560

tgaaaaagtt aatgcttaag agggaatgat atgcatttga cttgttaaac agcctattcc     1620

tgaactataa cacctgccac cactataaaa tgtcttcaag gcttcagtct catatttagt     1680

attgaatact tacattctct aataagaaaa ccacccctta gattgaagta aactgcagtc     1740

ctggagcaat cacagatgag ttatctaaga atacagcttt ctgaccttca gctcacgctt     1800

cacagtgatc gatgattcag gtgcagagga agtacaaact aaggtgctaa atctgcgatc     1860

atcgtcattt gctgtgaact gaaattaaaa ctattcatgc tacccagcca ttacccagct     1920

aaataatctt actctagata cctaaaacat aagatcactg ccagagataa actaatggtc     1980

cacacccaat tccactctga tagaattatt tcacaaataa taggtgtttg tttaatggac     2040

acttttcacc tccttcaatt ccatatatcc ttttcttcta tgtaggaaaa aaatagtcta     2100

gtgtagtatt cttccctttt aaacacattt tggttcttct caaaagaact tacccccatt     2160

cgcgctctgc tcagtgggta aaattagatg catgttgacc atgtctatga ttcgtgtaat     2220

tacttatccc tgcccatttc atattctttc aattctgtag gttaaaaaaa tggcagtgat     2280

gaattttaag ggtttccccc aacatataaa ataatgcaaa gaatccctag actttaggct     2340

ttcagcttac acaaatctat ttaattagga aaaaaactat taaggatgta gcttttcacc     2400

tttactttag aagcacagta aatatcccaa actgtgatga agccgacctt agatttagta     2460

gtgtaagcta gaagaagtga gtgtttctat gagtggaaaa agccaaggtg tcatttatgt     2520

gtcagttcat ttgtggtgat atagaattag ctttttcatc cccttaccct tagaatccac     2580

gtattcccct tcccactagc ctaggtcata aagaggcgtt gctttcactc tcctatgcct     2640

tttacgagtg ctaagtgtag gatattttgt caccagaaca caatgctacc gccccaaagt     2700

aaaagaaacc acttctggtc aatcaacact accagcgtat atataagaaa gacatctttc     2760

tcttttctaa aagacttccc taacacttac cccatggctg cacagttggt ggggtcctgc     2820

cggagaggaa gagacactca gaccagagaa ggggtgtgca tgcgcctact cgcttgctag     2880

aagtagattc tggacagtca gctcttcatc tgcccaactg tgtagcatct gcattgccca     2940

gtctttcatg tgtgccaagg ctgatgcagg atttgttctc tgtccagcag tcacttcggc     3000

cagagctgaa gagttgcccc gtctctgttc catgtctcct ttaagagctc tggtgataag     3060

gacatgatgc ttttactgaa ctttcttatc ctagcacatg cttcaatagt tcaaggaact     3120

tgaaaaatac ttttccttac ctttacccca tccctgtctt tactcctcac acttactgta     3180

agacattagt aacataataa attaaaagtc acacgaatct caccaacata a              3231


<210> 1717
<211> 2829
<212> DNA
<213> Homo sapiens

<400> 1717
tcagtggcgc tagcggcgga cccggctggg cagttccttc cccagaagga gagattcctc       60

tgccatggag tcctacgatg tgatcgccaa ccagcctgtc gtgatcgaca acggatccgg      120

tgtgattaaa gctggttttg ctggtgatca gatccccaaa tactgctttc caaactatgt      180

gggccgaccc aagcacgttc gtgtcatggc aggagccctt gaaggcgaca tcttcattgg      240

ccccaaagct gaggagcacc gagggctgct ttcaatccgc tatcccatgg agcatggcat      300

cgtcaaggat tggaacgaca tggaacgcat ttggcaatat gtctattcta aggaccagct      360

gcagactttc tcagaggagc atcctgtgct cctgactgag gcgcctttaa acccacgaaa      420

aaaccgggaa cgagctgccg aagttttctt cgagaccttc aatgtgcccg ctcttttcat      480

ctccatgcaa gctgtactca gcctttacgc tacaggcagg accacagggg tggtgctgga      540

ttctggggat ggagtcaccc atgctgtgcc catctatgag ggctttgcca tgccccactc      600

catcatgcgc atcgacatcg cgggccggga cgtctctcgc ttcctgcgcc tctacctgcg      660

taaggagggc tacgacttcc actcatcctc tgagtttgag attgtcaagg ccataaaaga      720

aagagcctgt tacctatcca taaaccccca aaaggatgag acgctagaga cagagaaagc      780

tcagtactac ctgcctgatg gcagcaccat tgagattggt ccttcccgat tccgggcccc      840

tgagttgctc ttcaggccag atttgattgg agaggagagt gaaggcatcc acgaggtcct      900

ggtgttcgcc attcagaagt cagacatgga cctgcggcgc acgcttttct ctaacattgt      960

cctctcagga ggctctaccc tgttcaaagg ttttggtgac aggctcctga gtgaagtgaa     1020

gaaactagct ccaaaagatg tgaagatcag gatatctgca cctcaggaga gactgtattc     1080

cacgtggatt gggggctcca tccttgcctc cctggacacc tttaagaaga tgtgggtctc     1140

caaaaaggaa tatgaggaag acggtgcccg atccatccac agaaaaacct tctaatgtcg     1200

ggacatcatc ttcacctctc tctgaagtta actccacttt aaaactcgct ttcttgagtc     1260

ggagtgtttg cgaggaactg cctgtgtgtg agtgcgtgtg tggatatgag tgtgtgtgca     1320

catgcgagtg ccgtgtggcc ctgggaccct gggcccagaa aggacgatga actacctgca     1380

gtggtgatgg cctgaggcct ggggttgacc actaactggc tcctgacagg gaagagcgct     1440

ggcagaggct gtgctccctc ctcaggtggc ctctggctgg ctgtggggga ctccgtttac     1500

taccacaggg agacagaggg aggtaagcca tcccccggga gaccttgctg ctgaccatcc     1560

taggctgggc tggccccacc ctcaccccca cccccagggt gccctgaggc cccaggcagc     1620

tgctgcctcc actatcgatg cctcctgact gcacactgag gactgggact ggggttgagt     1680

tctgtctggt tttgttgcca ttttggtttg ggaggctgga aaagcacccc aagagctatt     1740

acagagactg gagtcaggag agagcaggag gccctcatgt tcaccaggga acaggaccac     1800

accggccact ggaggagggc aggagcagtc ctcactctga atggctgcag agttaatgtt     1860

cccagcccag tcccctttcg ggggccttgg gagagtttaa ggcacctgct ggttccagga     1920

cctcgctttc catctgttct tgttgcaatg ccatcttcaa accgttttat ttattgaagt     1980

gtttgttcag ttaggggctg gagagaggga gcttgctgcc tcctgccttg ctacactaat     2040

gtttacagca cctaagctta gcctccaggg ccccacctct cccagctgat ggtgagctga     2100

cagtgtccac aggttccagg accatttgag attggaagct acactcaaag acactcccac     2160

caggctcttt ctcccttttc ctcttgctca ctgccctgga atcaacaggc tggttgctgg     2220

ttagattttc tgaaacagga ggtaaaattt ttctttggca gaggccccta agcaagggag     2280

gggtgttgga gagccagtgc ccttaagact ggagaaagct gcaatttacc aagttgcctt     2340

ttgccactgt agctgaccag gggactaggt tgtagaggtg ggaaggcccc ctctgggctg     2400

atcttgtgcc attcttgacc ttggacctgc ttggttaagg agggagtggg ccagaccaga     2460

gtgccaggag ctaatggagc caggcctgac tcctaggagt ggtccaaagg ccttcagcct     2520

agatggtgca aagctggggc cagcctgtct tcaccggcac cctcacctgt gacaccaaga     2580

cccaccccaa tcccagactt cacacagtat tctcccccac gccgtcctat gaccaaaggc     2640

ccctgccagg tgtgggccac agcagcaggt atgtgtgaaa gcaacgtagc gccccgcgga     2700

ctgcagtgcg cttaaccaac tcacctccct tctcttagcc caagcctgtc cctcgcacag     2760

cctcgcacaa accacattgc ctggtggggc ccagtgtact gaaataaagt cgttccgata     2820

gacacgtca                                                             2829


<210> 1718
<211> 1157
<212> DNA
<213> Homo sapiens

<400> 1718
ccatcccggc atactttgcg ccgtgcacag gcaagccctg gtgcgcattg gccccttcgg       60

ccgccgtcgg ccggtagtta ctatggaaac ccagctgcca tcgctatgtc tctgcaaaag      120

acccctccga cccgagtgtt cgtggaactg gttccctggg ctgaccggag ccgggagaac      180

aacctggcct cagggagaga gacgctaccg ggcttacgcc accccctctc ctcaacacaa      240

gcccaaactg ctacccgcga ggtgcaagta agcggcacct cagaagtgtc tgcgggccct      300

gaccgggcgc aggtggtggt gcgagtgagc agcaccaagg aggcggcagc cgaggccaaa      360

aagagcgttt gtcgccgtct agattacatc acgcagagcc tccagcagca gggcgtgcag      420

gcagaaaata taactgtgac aaaggatttt aggagagtgg aaaatgctta tcacatggaa      480

gcagaggtct gcattacatt tactgaattt ggaaaaatgc aaaatatttg taactttctt      540

gttgaaaagc tagatagctc tgttgtcatc agcccacccc agttctatca tactccaggt      600

tctgttgaga atcttcgacg gcaagcctgt cttgttgctg ttgagaatgc gtggcgcaaa      660

gctcaagaag tctgtaacct tgttggccaa accttaggaa aacctttact aatcaaagaa      720

gaagaaacaa aagaatggga aggccaaata gatgatcacc agtcatccag actctcaagt      780

tcattaactg tacaacaaaa aatcaaaagt gcaacaatac atgctgcttc aaaagtattt      840

ataacttttg aggtaaaggg aaaagagaag agaaaaaagc acctttgaaa ttccaaacaa      900

attatattgt acttgtatct ttttacctat ttttatactt tttataatgt ttacgtttgt      960

cctgaatata tatatatata tatatatata tatatatatg gtataggaga taagctattt     1020

ctttccaaaa tctataaatc tttgaatata gtcccacaga atacttatgt tcactttcta     1080

tttttaaaag actactctga aaaacactct tggataataa atgtattatg tgcatactta     1140

tatactgaca gttcata                                                    1157


<210> 1719
<211> 2344
<212> DNA
<213> Homo sapiens

<400> 1719
ctccctaagc aggctgagga agaagagata gcaagccctc acctaacttg acccctttct       60

tgtctctccc cgctgctagc ttctcccttc tcgctgcctt gcggggtggg gaaacgtgga      120

aggaattctg ggaaaaccag atgtctgggt tctctattcc cgtctggctt gattctggac      180

aaggggcttc ctctccaggg cctcggtttc cccatcttta aaatggactg atagcataga      240

cctgcccacc tttcagaggt gcccgaagcc ttgacgagat aacagatgag aagtggtttt      300

cgttgtgatg agccagctga agcggttgca ccggagcgcc agaccgtcag cggtgcagtg      360

gctctcgcgt ccttcacatc cccccacacc catcccgtgg atgatggggg aaggcactac      420

tcctggggtt ccccgaagcg gatcctggga ctgggacctg gggacgcggt gagaggcagc      480

cctgaagctg agtccagagg tctggggcgt cattgtccca gggcggaccc agccccagac      540

cctacaacta aacccaaggc cagccgagaa gcactaccac tggcgggctg agctgagctc      600

tcattcttct taggactctg gacctttgga ggaaatgaaa gggacccagt tggaaatata      660

gtctttcttc gcgcccccta catctctctc ccccggcgga aacgcggccc aaactgttac      720

gaagtggaag aggctggata gctcttcata attaatcagg aatgggaggt ttgagcaggt      780

ttacttgatg agggaaacat tatagcctcg ccaattcatt cattatttca acaattactt      840

attgaacacc tgctacgtgg cagacagtaa gagcctggat agtttctccc cgtttttcaa      900

agtcgctaaa cgcgaccaga gggcagagga gaggccggta acctaagagt cctggctccg      960

ccccctccgc gtttggcctt gcctgctcct cccaccacca cttcgctcag aggcggctac     1020

tggctcaaga ggacgacaga agccagtctc tgatgcccac cgcattctcc agcttcaggc     1080

ctcaagccct gtagccgaga aggcgaggcc taatgttaca ccaccggtct gttccgcctc     1140

cgtttcgggg tccacccgaa aagctttcag atcggatcct cggtgagacg gcactcgatt     1200

aaataggtct gtctctacag gccaaggagg cgggtttggt gcggccactc caaggccaaa     1260

gcgagaaaat cttactgcgc acgcgcaata gacagccgat ggagccaccg atggagccgt     1320

ccggagggga gcaagagccc ggagccgtca ggttcctgga cctgccctgg gaagacgtgc     1380

tgctcccaca cgtcctgaac cgggtcccgc tgcgccagct gctccggctg cagcgcgtta     1440

gccgggcctt ccggtcgctg gtgcagcttc acctggccgg gctgcgtcgc ttcgatgccg     1500

cgcaggtggg tccgcagatc ccgcgggccg cattggcccg gctgctgcgg gatgccgagg     1560

ggctgcagga gctggcactg gcgccgtgtc acgaatggct gtcagacgag gacctggtgc     1620

cggtgctggc gcggaatccg cagctgcgga gtgtggcgtt gggcggctgc gggcaactga     1680

gtcgccgggc gcttggggct ttggccgagg gctgcccacg cctgcagcgc ctgtcgctcg     1740

cgcactgtga ctgggtggac gggctggcgc tgcgcggcct cgctgatcgc tgcccggccc     1800

tggaggagct ggatctcacc gcctgccgcc agctcaagga cgaggccatc gtgtacctgg     1860

cgcagaggcg cggcgctggt ctccgcagcc tctctctggc cgtcaacgcc aacgtggggg     1920

acgccgcggt tcaagagttg gctcggaact gcccagaact ccaccacctt gacctcaccg     1980

gctgcctccg cgtcggaagc gacggtgtca ggacattggc cgagtactgc cccgtgctgc     2040

gttcgctgcg ggtgcggcac tgccaccatg tggcggagtc cagcctgagc cgcttgcgga     2100

agcgcggcgt ggacatcgac gtggagccgc cgctgcacca ggccctggtg ctgctgcagg     2160

atatggcggg cttcgcacct tttgtcaacc tgcaggtctg acccgcctgc caatcggagc     2220

acagctggac tgtgtggctg gggcctgaca ctgagctgta gggaaactga actgtgagga     2280

cctctggtga gaggccagtg ccctgcccca ccctggagct tcaaataaag agctttttac     2340

cccc                                                                  2344


<210> 1720
<211> 3748
<212> DNA
<213> Homo sapiens

<400> 1720
ttcctgagtc gtgctgcgtc gacaacggta gtgacgcgta ttgcctggag gatggcggac       60

gccggcattc gccgcgtggt tcccagcgac ctgtatcccc tcgtgctcgg cttcctgcgc      120

gataaccaac tctcagaggt ggccaataag ttcgccaaag cgacaggagc tacacagcag      180

gatgccaatg cctcttccct cttagacatc tatagcttct ggctcaagtc tgccaaggtc      240

ccagagcgaa agttacaggc aaatggacca gtggctaaga aagctaagaa gaaggcctca      300

tccagtgaca gtgaggacag cagcgaggag gaggaggaag ttcaagggcc tccagcaaag      360

aaggctgctg tacctgccaa gcgagtcggt ctgcctcctg ggaaggctgc agccaaagca      420

tcagagagta gcagcagtga agagtccagt gatgatgatg atgaggagga ccaaaagaaa      480

cagcctgtcc agaagggagt taagccccaa gccaaggcag ccaaagctcc tcctaagaag      540

gccaagagct ctgattctga ttctgactca agctccgagg atgagccacc aaagaaccag      600

aagccaaaga taacacctgt gacagttaaa gctcagacta aagcccctcc caaaccagct      660

cgagcagcac ctaaaatagc caatggtaaa gcagccagta gcagcagtag cagcagcagc      720

agcagtagca gtgatgactc agaggaggag aaggcagcag ccacccccaa gaagactgta      780

cctaaaaagc aagttgtggc caaggcccca gtgaaagcag ctaccacccc tacccggaag      840

agttctagca gtgaggattc ctccagtgac gaggaagagg agcaaaaaaa acccatgaaa      900

aataaaccag gtccctacag ttcagtcccc ccgccttctg ctcccccacc aaagaagtct      960

ctgggaaccc agcctcccaa gaaggctgtg gagaagcagc agcctgtgga aagcagtgaa     1020

gacagcagtg atgagtctga ttcaagttct gaagaagaga agaaaccccc aactaaggca     1080

gtagtctcta aagcaaccac taaaccacct ccagcaaaga aagcagcaga gagctcttca     1140

gacagctcag actctgacag ctctgaggat gatgaagctc cttctaagcc agctggtacc     1200

accaagaatt cttcaaataa gccagctgtc accaccaagt cacctgcagt gaagccagct     1260

gcagccccca agcaacctgt gggcggtggc cagaagcttc tgacgagaaa ggctgacagc     1320

agctccagtg aggaagagag cagctccagt gaggaggaga agacaaagaa gatggtggcc     1380

accactaagc ccaaggcgac tgccaaagca gctctatctc tgcctgccaa gcaggctcct     1440

cagggtagta gggacagcag ctctgattca gacagctcca gcagtgagga ggaggaagag     1500

aagacatcta agtctgcagt taagaagaag ccacagaagg tagcaggagg tgcagcccct     1560

tccaagccag cctctgcaaa gaaaggaaag gctgagagca gcaacagttc ttcttctgat     1620

gactccagtg aggaagagga agagaagctc aagggcaagg gctctccaag accacaagcc     1680

cccaaggcca atggcacctc tgcactgact gcccagaatg gaaaagcagc taagaacagt     1740

gaggaggagg aagaagaaaa gaaaaaggcg gcagtggtag tttccaaatc aggttcatta     1800

aagaagcgga agcagaatga ggctgccaag gaggcagaga ctcctcaggc caagaagata     1860

aagcttcaga cccctaacac atttccaaaa aggaagaaag gagaaaaaag ggcatcatcc     1920

ccattccgaa gggtcaggga ggaggaaatt gaggtggatt cacgagttgc ggacaactcc     1980

tttgatgcca agcgaggtgc agccggagac tggggagagc gagccaatca ggttttgaag     2040

ttcaccaaag gcaagtcctt tcggcatgag aaaaccaaga agaagcgggg cagctaccgg     2100

ggaggctcaa tctctgtcca ggtcaattct attaagtttg acagcgagtg acctgaggcc     2160

atcttcggtg aagcaagggt gatgatcgga gactacttac tttctccagt ggacctggga     2220

accctcaggt ctctaggtga gggtcttgat gaggacagaa gtttagagta ggtcctaaga     2280

ctttacagtg taacatcctc tctggtcctt ttctgtgttc ctagttttgt acagacttgt     2340

ttttgagtgt tgagtagcag ggacaaaata agggaatgtt attttttaag aaaattcatt     2400

ttcattgttg tctccttcct tttctgtgaa agtcctcata ctgagaaatt tgtatatttt     2460

atattaaatc acttactatt gatttttgtt gtgattttca aaggtggatt cccacagata     2520

aaatcttggc tattgcccaa aacatagtaa agggtcacgt gtgacttttt ataataggaa     2580

gaaaattctg cctttgtgag tgcacatgtc cacatttcat ccctccttcc ctcaaaaccc     2640

tagagagggg cattaaagaa ttgttgatgt atatgcaatg tctgttaagc atgcactatg     2700

tatttcatcc tcatttattg ggtctgggac tgaagttttt agccagcatg gacctaacct     2760

actttttggg ataaaattct ctgttttgtt acaggcaaaa ttctggtatg gcgtgaatgc     2820

catgggtcat tctgaatata tttttttctg taattttatc attacacgat gtttgcaata     2880

cgtgctttgt tttttaattt gaaagcaaac ttttctactg ttgaaagaca ttttttgaca     2940

acttgaccct tcctagtatt gagttctaag ttgaggactg catcttctcg ttttttacag     3000

tatagagaac aaaatgacat gagtttgaaa aatacatatc acttggtatt gctgtcttgg     3060

ttgcagtggt gatacagaat tggtttcatt aattcctaca tggttgagaa tcactgatca     3120

agaaagtggg gggaaaaaaa acaaacgtta aaacctcaat cctcagtagg aaggtagatt     3180

acattaggtg aaattatagg taatctatgt atgtgctaat ggggttggaa agaaccttac     3240

agagcatatt acctgataaa ctggagtggg tttgggagaa caaactaata ggattattgt     3300

gtctcctagt tggtacctgg gagcaattga catgccccct tcagaacctt aactgttagt     3360

agcagtggct gtaacaacac aaaccagtga ccagagataa cagcttttag gccaagctgg     3420

cctgacggta tggctgcagg aagtgactga gcagtagcgg tactcagcca gaccaagacg     3480

gagagggaag agtccacagc tttctggaag ctaaggcatt ctggtggtag aaaagtgtgc     3540

cccaagcctt catggacgag ttataggtct taagattagt ctcctcttgt ttggattcca     3600

tacttgctaa ataacctgat aataacctgg ttttccatgt aactgcctct aggaagaaaa     3660

tgtactgttc atgctgacac agatatttca gtctgcatgg taaaagttct aaatcttact     3720

acaaaataat aaactggctg gtttataa                                        3748


<210> 1721
<211> 1717
<212> DNA
<213> Homo sapiens

<400> 1721
tccgcgacga gctttgtttt ttcggttggg catgctgctt accgcaggat gatggaagcg       60

acggcccgta caaagacaga agcgttggtt tcactgagtc agtgctgatt ctctcaaata      120

gagcttgaag gataaatctt catttttgtt tcaacaaaac ttcgaaacaa aatggaagaa      180

aataatctac agtgcagtag tgtggttgac ggtaattttg aagaagttcc cagggagacg      240

gcaattcagt ttaaacctcc actatacaga cagcggtacc agttcgttaa aaatttagtg      300

gatcaacatg agcctaagaa ggttgcagac ctgggatgtg gtgatacttc actcttaagg      360

ctgctaaaag tcaatccatg cattgaattg cttgttggag tagatattaa tgaggataaa      420

ttacgatgga gaggggattc gttagctcct ttcctggggg attttctgaa acctcgggat      480

ctgaatttga ccatcacatt gtatcatggc tccgttgtgg agagagactc tcgtttgctt      540

ggatttgact tgataacgtg tattgaatta atagaacatt tggattcagg tgatctggcc      600

agatttcctg aagtggtatt tgggtacctg tctccatcca tgattgtcat cagcacacca      660

aactctgaat tcaatcccct gtttccatca gtgaccttaa gagattcaga tcataaattt      720

gagtggacca gaatggagtt tcagacctgg gctttatatg tggcaaatcg ctatgattac      780

tctgtggagt ttactggtgt cggggaacca ccagctggag ctgagaatgt tggatactgt      840

acccagatag gaatcttccg gaaaaatgga ggaaaggcaa cagaatcatg tctttcagag      900

cagcatgatc agcatgttta taaagctaga cagggtctca ctatgttgcc caggctggtc      960

ttgaacttcc atcctcaagc aatcctcctg ccccatcttc ctaaaatgct gagattacag     1020

gtttttacca cctcataccc aagcttacag caggaaaggt tctttaaact tgtgttggtt     1080

aatgaggtgt cccaacaagt ggaaagctta agagtgagcc acctgccaag gcggaaagaa     1140

caggctgggg aacggggtga taagcccaaa gacattggtg gctcaaaggc ccctgtccca     1200

tgctttggac cagtcttcac agaggttgag aaggccaaga tagagaactc tcccacaccc     1260

ttctgtgttg gagataaatt tttcgtacct ctgcagagac tccttgcgta tcccaagttg     1320

aaccgcttat gtgctaatga agagatgatg agatcagtca ttgctgactc aattcctctg     1380

agcagtgatg gttctgcagt ggtggctgac ctgcgtaatt attttgatga acagtttgag     1440

ttttgaacca tgtttatttc ctgaaatttc agggtctcag cgatagttgt gctcacttag     1500

aatttagttt tttttgtgta atcctaattc aagtaatgtt tttaaagttt cactgcaaaa     1560

gtctatgttc caagccattg gacagacctg cttgagatat ggccagactg cagtgagccc     1620

tgagaaagat atgagggttt aaaacgggtg ctttcctttg attttggact tttttgtttt     1680

ctcaagaata aagaagttgg atgtggtaat atgttaa                              1717


<210> 1722
<211> 1874
<212> DNA
<213> Homo sapiens

<400> 1722
gtttttaggc ctttgccacg cctcgggagc gccacgaact caacagccgc ccaagccgcc       60

ttccggctcg cggtctgcgg acgcgctcgg agttgggggc cttcgccaac agctgccgta      120

ccgtgccgcg tcgcagccgc acgctagcgg ggtcaacggc gcggcaggcg caggggtcct      180

cgccaaggtt cggaagagga ccttgaaaat ggcttctggg catgcgccac agcggccgtt      240

acgagacgca aaaccgacgc cttggaactg agagcctaga gggacggagc tcggcgcacc      300

atgaggctcc cggggcccaa ggccgaccgt gagagcgcac gagctgagtc agtgctgatt      360

ctctcaaata gagcttgaag gataaatctt catttttgtt tcaacaaaac ttcgaaacaa      420

aatggaagaa aataatctac agtgcagtag tgtggttgac ggtaattttg aagaagttcc      480

cagggagacg gcaattcagt ttaaacctcc actatacaga cagcggtacc agttcgttaa      540

aaatttagtg gatcaacatg agcctaagaa ggttgcagac ctgggatgtg gtgatacttc      600

actcttaagg ctgctaaaag tcaatccatg cattgaattg cttgttggag tagatattaa      660

tgaggataaa ttacgatgga gaggggattc gttagctcct ttcctggggg attttctgaa      720

acctcgggat ctgaatttga ccatcacatt gtatcatggc tccgttgtgg agagagactc      780

tcgtttgctt ggatttgact tgataacgtg tattgaatta atagaacatt tggattcagg      840

tgatctggcc agatttcctg aagtggtatt tgggtacctg tctccatcca tgattgtcat      900

cagcacacca aactctgaat tcaatcccct gtttccatca gtgaccttaa gagattcaga      960

tcataaattt gagtggacca gaatggagtt tcagacctgg gctttatatg tggcaaatcg     1020

ctatgattac tctgtggagt ttactggtgt cggggaacca ccagctggag ctgagaatgt     1080

tggatactgt acccagatag gaatcttccg gaaaaatgga ggaaaggcaa cagaatcatg     1140

tctttcagag cagcatgatc agcatgttta taaagctgtt tttaccacct catacccaag     1200

cttacagcag gaaaggttct ttaaacttgt gttggttaat gaggtgtccc aacaagtgga     1260

aagcttaaga gtgagccacc tgccaaggcg gaaagaacag gctggggaac ggggtgataa     1320

gcccaaagac attggtggct caaaggcccc tgtcccatgc tttggaccag tcttcacaga     1380

ggttgagaag gccaagatag agaactctcc cacacccttc tgtgttggag ataaattttt     1440

cgtacctctg cagagactcc ttgcgtatcc caagttgaac cgcttatgtg ctaatgaaga     1500

gatgatgaga tcagtcattg ctgactcaat tcctctgagc agtgatggtt ctgcagtggt     1560

ggctgacctg cgtaattatt ttgatgaaca gtttgagttt tgaaccatgt ttatttcctg     1620

aaatttcagg gtctcagcga tagttgtgct cacttagaat ttagtttttt ttgtgtaatc     1680

ctaattcaag taatgttttt aaagtttcac tgcaaaagtc tatgttccaa gccattggac     1740

agacctgctt gagatatggc cagactgcag tgagccctga gaaagatatg agggtttaaa     1800

acgggtgctt tcctttgatt ttggactttt ttgttttctc aagaataaag aagttggatg     1860

tggtaatatg ttaa                                                       1874


<210> 1723
<211> 1753
<212> DNA
<213> Homo sapiens

<400> 1723
acaggagcag ccgcccgggg caccggagct gcgggctgcg tggccgggat gagcgccagc       60

acgggcggtg gtggggacag cggcggcagc ggcggcagta gcagcagctc acaggcctcc      120

tgcgggcccg agtcctcggg ctccgaacta gccctggcca caccggtgcc tcagatgctg      180

cagggccttc tgggctccga cgacgaggaa caggaagacc ccaaagacta ctgcaagggc      240

ggctaccacc ctgtgaagat cggcgacgtg ttcaatgggc ggtaccacgt ggtgcgcaaa      300

ctgggctggg gccacttctc caccgtctgg ctctgctggg acatccagcg caagcgcttt      360

gtggccctca aagtggtgaa gagtgcgggg cattacacgg agacagctgt ggatgagatc      420

aagctcctga aatgtgtccg ggacagcgac cccagtgacc ccaaaagaga gaccattgtc      480

cagctcattg atgacttcag gatctcagga gtcaatggag tccatgtgtg catggtgctg      540

gaggtgctgg gccaccagct cctcaaatgg atcatcaagt ccaactacca gggcctgccc      600

gtgccctgcg tgaagagcat cgtgaggcag gtgctgcacg gcctggacta cctccacacc      660

aagtgcaaga tcatccacac ggacatcaag cccgagaaca tcttgctgtg tgtgggggac      720

gcttacatca ggcgcctggc tgccgaggcc acggagtggc aacaggcagg ggcgccgccc      780

ccctcccgct ccatagtcag cactgccccc caggaggtct tgaccggtaa gctgtccaaa      840

aacaagagga agaagatgag gcgcaaacgg aaacagcaga agcggctgct ggaggagcgg      900

ctgcgggacc tgcagaggct ggaggccatg gaggctgcca cccaggctga ggactctggc      960

ttgagactag acgggggcag cggctccaca tcctcttcag gctgtcaccc cgggggcgcc     1020

agagcaggtc cctccccagc ctcttcctcc cccgccccag ggggcggccg tagcctcagc     1080

gcgggctcac agacctcagg cttctccggc tccctcttct ctcctgcctc ctgctccatc     1140

ctctccggct cgtccaatca gcgagagacc gggggcctcc tgtcgcctag cacaccattc     1200

ggtgcctcga acctcctggt gaaccccctg gagccccaaa atgcagataa gatcaagatc     1260

aagatcgcag acctgggcaa cgcctgctgg gtgcacaagc acttcacgga agacatccag     1320

actcggcagt accgggccgt cgaggtgctg atcggcgccg aatacggccc cccggcagac     1380

atctggagca cagcctgcat ggccttcgag ctggccactg gtgactacct gttcgagccg     1440

cattctggag aagactacag tcgtgatgag gaccacatcg ctcacatagt ggagcttctg     1500

ggggacatcc ccccagcctt cgccctctca ggccgctatt cccgggagtt cttcaaccgg     1560

agaggagagc tgcggcacat ccacaatctc aagcactggg gcctgtacga ggtactcatg     1620

gaaaagtacg agtggcccct agagcaggcc acacagttca gcgcctttct gctgcccatg     1680

atggagtaca tccccgaaaa gcgggccagt gccgctgact gcctccagca cccctggctc     1740

aacccctagg ccc                                                        1753


<210> 1724
<211> 538
<212> DNA
<213> Homo sapiens

<400> 1724
gaactactgg gcgggagcca acgtctcttc tttctcccgc tctggcggag gctttgtcgc       60

tgcgggctgg gccccagggt gtcccccatg gcggggccgc gggtggaggt cgatggcagc      120

atcatggaag ggggcggcca gatcctgaga gtctctacgg ccttgagctg tctcctaggc      180

ctccccttgc gggtgcagaa gatccgagcc ggccggagca cgccaggcct gaggtaaatc      240

tggctggagg gggagttggg ccgtgaagct gggggatcgg ggggtcgggc tgccgggctg      300

gggcatcggg agtccgagtg gtggaaccca gaaggtccca gacgcaggta tgggcgatcc      360

agggcggggc actctgcctg ggcggtggcc tgggttgtaa agtcttgaaa gcctggaggg      420

gtgagtttag aaatggtctc gagttttctc tgtttgacta aatagtgtca tttgctgaag      480

agctagcttt taaaatgttt tctcacctca ccgggcattc caaatatccg aacagcac        538


<210> 1725
<211> 2535
<212> DNA
<213> Homo sapiens

<400> 1725
gctgactcca gtgtcccgag aggcgccgct tcttccgctt tctcgtcagg ctcctgcgcc       60

ccaggcatga accaaggttt ctgaactact gggcgggagc caacgtctct tctttctccc      120

gctctggcgg aggctttgtc gctgcgggct gggccccagg gtgtccccca tggcggggcc      180

gcgggtggag gtcgatggca gcatcatgga agggggcggc cagatcctga gagtctctac      240

ggccttgagc tgtctcctag gcctcccctt gcgggtgcag aagatccgag ccggccggag      300

cacgccaggc ctgaggcctc aacatttatc tggactggaa atgattcgag atttgtgtga      360

tgggcaactg gagggggcag aaattggctc aacagaaata acctttacac cagagaagat      420

caaaggtgga atccacacag cagataccaa gacagcaggg agtgtgtgcc tcttgatgca      480

ggtctcaatg ccgtgtgttc tctttgctgc ttctccatca gaacttcatt tgaaaggtgg      540

aactaatgct gaaatggcac cacagatcga ttatacagtg atggtcttca agccaattgt      600

tgaaaaattt ggtttcatat ttaattgtga cattaaaaca aggggatatt acccaaaagg      660

gggtggtgaa gtgattgttc gaatgtcacc agttaaacaa ttgaacccta taaatttaac      720

tgagcgtggc tgtgtgacta agatatatgg aagagctttc gttgctggtg ttttgccatt      780

taaagtagca aaagatatgg cagcggcagc agttagatgc atcagaaagg agatccggga      840

tttgtatgtt aacatccagc ctgttcaaga acctaaagac caagcatttg gcaatggaaa      900

tggaataata attattgctg agacctccac tggctgtttg tttgctggat catcgcttgg      960

taaacgaggt gtaaatgcag acaaagttgg aattgaagct gccgaaatgc tattagcaaa     1020

tcttagacat ggtggtactg tggatgagta tctgcaagac cagctgattg ttttcatggc     1080

attagccaat ggagtttcca gaataaaaac aggaccagtt acactccata cgcaaaccgc     1140

gatacatttt gctgaacaaa tagcaaaggc taaatttatt gtgaagaaat cagaagatga     1200

agaagacgcc gctaaagata cttatattat tgaatgccaa ggaattggga tgacaaatcc     1260

aaatctatag agtatttgcc tcttaaatga tacctcattg atatattgca ctatttcata     1320

aatactataa aataatgact aggaagtaac ttattaaagg ctatgactta aatttgaaga     1380

tgaagtacag tgttctaggt ttgctgagaa ggcttcatta aattaatctc actttgaata     1440

tctcctgaga gatggacaat gaaatatcag ttggtggata tgtgtgatag ctgatttcaa     1500

tattgaagta ttgaaataaa atattcttta cacctgaagt aaatacattt ttctttttta     1560

tgtaattaat taaatcaggg atatagattt gatctgtaat ttgggtataa ttctaatctt     1620

tgctgaaatc acatctcaag tataatgagg caactttatg caaatgtact tgttgtgaca     1680

acaataacat tttccttttt tttttttttt tttgagacag tctcgttctg tcacccaggc     1740

tggggtgctg tggtgtgatc ttggctcact gcaacctctg cctcccgggt tcaagcaatt     1800

ctactgcctc agcttcctga gtagttggta ttacaccacc atgcccagct aatttttgta     1860

tttttagtag agacagggtt tcaccatatt ggtcaggctg gtttcgaact cctgacctcg     1920

tgatctgccc gcctcggcct cccaaagtgg tgggattaca ggcgtgagcc agtgcacccg     1980

gcaacaataa catttaatag gcattgtctc attctaatga tatatacctt ctacctagtg     2040

ggcactttgt acatatttat tttttatttt atttattcat tttttttgag acagagtctc     2100

actctgtcac caagttggag tgcagtggca caatctcagc tcactgcaac ctccgccttc     2160

caggttgaag tgattctcca gcctcagcct cccgagtagc tgggactcca ggcacgtacc     2220

accataccca gataattttt gcatttttag tagagacggg gtttcaccat gttggctagg     2280

atggtctcca tctcctgacc tcgtgatccg cccaccttgg cctcccaaag tgctgggatt     2340

acaggcatga gccaccacag ctggtcgtaa atattttttg aatttgaatc tgttttggaa     2400

gccaaatatg ttttggaagc caaacaatta agagaagtaa aattttaacc ctagtaggtt     2460

tcgcagattc atccccagat atgtttttgt ttggcttgtg ttattaacaa ataaatgagt     2520

gtctttcaaa tggaa                                                      2535


<210> 1726
<211> 2289
<212> DNA
<213> Homo sapiens

<400> 1726
cgcttcccgc cgcccgagct tcggaaactt cccggccgcg acgcagggaa ccggcgcgga       60

gaaccgagca gagcggagcg cccgtggtcc agcgtgtagg gagccgatcg cccatggagg      120

gtctgggccg ctcgtgcctg tggctgcgtc gggagctgtc gcccccgcgg ccgcggctcc      180

tgctcctgga ctgccgcagc cgcgagctgt acgagtcggc gcgcatcggt ggggcgctga      240

gcgtggccct gccggcgctc ctgctgcgcc gcctgcggag gggcagcctg tcggtgcgcg      300

cgctcctgcc tgggccgccg ctgcagccgc ccccgcctgc ccccgtgctc ctgtacgacc      360

agggcggggg ccggcgccgg cgcggggagg ccgaggccga ggccgaggag tgggaggccg      420

agtcggtgct gggcaccctg ctgcagaagc tgcgagagga aggctacctg gcctactacc      480

tccagggagg cttcagcaga ttccaggccg agtgccctca cctgtgtgag accagccttg      540

ctggccgtgc cggctccagc atggcgccgg tgcccggtcc agtgcccgtg gtggggttgg      600

gcagcctgtg cctgggctcc gactgctctg atgcggaatc cgaggctgac cgcgactcca      660

tgagctgtgg cctggattcg gagggtgcca cacccccacc agtggggctg cgggcatcct      720

tccctgtcca gatcctgccc aacctctatc tgggcagtgc ccgggattcc gccaatttgg      780

agagcctggc caaactgggc atccgctaca tcctcaatgt cacccccaac ctcccaaact      840

tcttcgagaa gaatggtgac tttcactaca agcagatccc catctccgac cactggagcc      900

agaacctgtc gcggttcttt ccggaggcca ttgagttcat tgatgaggcc ttgtcccaga      960

actgcggggt gctcgtccac tgcttggcgg gggtcagccg ttctgtcacc gtcactgtgg     1020

cctacctcat gcagaagctc cacctctctc tcaacgatgc ctatgacctg gtcaagagga     1080

agaagtctaa catctccccc aacttcaact tcatggggca gttgctggac tttgagcgca     1140

gcttgcggct ggaggagcgc cactcgcagg agcagggcag tggggggcag gcatctgcgg     1200

cctccaaccc gccctccttc ttcaccaccc ccaccagtga tggcgccttc gagctggccc     1260

ccacctaggg ccccgtggcc ggcaggccgg cccctgcccc acccccaccc acgggtgtcc     1320

ctgcccactc gtgtggcaag ggaggggagg gcaggagggc tcggcctgag cagggtgctg     1380

gggggagagc gcaatacctc acgcgggctg ccgtcctaat caacgtgcct atggcgggac     1440

cacgctcgga gcctgcctct tctgcgactg ttactttttc tttgcgggat gggggtgggg     1500

gttccctctc caggtggttg tccaggccca tgtcccggcc ctgggtgctc agccagctcg     1560

gctaggccct gcgcctccct gcgcttcccc cttcaggaag ggtgtgtgcc acctcgttgc     1620

actggatccc agtggctgct tgggggagag gcgtttgcca tcactggtgt tgtcacctcc     1680

ctgtttctcc accaagggct tgggcctctc ggggctgggg cctcccaggg gatggggacc     1740

cagagtgcag tggccgccca catccatggc ctaggagcta ctgggcaggt tcccggccac     1800

acatctggtg ggctgttttg tttttttttt ttcctcttcc cccagatgtc ttgacgggat     1860

cactggggct ctttgtgagt gagggtggcc aaactaccgc cggaggagat ggggtctcag     1920

agcgagagct gcggaggggg aggggaagaa gaaggcctca cttttgctgc tgcggggccc     1980

acacagccgc tgctactttg gggggtgggg aaggggccaa gctgcagaca cacacagtca     2040

ttcatttctg tccacacccc tgtgggtggc gggtgtgcgt gtgtgtgctt gtgtgtgcgc     2100

acgtgtcggc gctcacacac acatgctagc ccactgatgc acccagccca gggctggcag     2160

tctttgcagc gtggggccgt ctcaccctgg agcctggaga ggatctatgc ttgtttgttt     2220

ttgtaatcca tatcatagtt gctttcttta attgttcctt ctgaataaac agtttattta     2280

agatactga                                                             2289


<210> 1727
<211> 1235
<212> DNA
<213> Homo sapiens

<400> 1727
agtgctgctc ctggccggtg gaggcggcgg ctgcggcagc ggaaggggaa gcgctgaggc       60

ggtggggccc acagccatgg cggagcctgt gcaggaggag ctctcggtcc tggccgcgat      120

tttctgcagg ccccacgagt gggaggtgct gagccgctca gagacagatg ggaccgtgtt      180

cagaattcac acaaaagctg aaggatttat ggatgtggat atacctctgg aattggtgtt      240

ccatttgcca gtcaattatc cttcatgtct acctggtatc tcgattaact ctgaacagtt      300

gaccagggcc cagtgtgtga ctgtgaaaga gaatttactt gagcaagcag agagcctttt      360

gtcggagcct atggttcatg agctggttct ctggattcag cagaatctca ggcatatcct      420

cagccaacca gaaactggca gtggcagtga aaagtgtact ttttcaacaa gcacgaccat      480

ggatgatgga ttgtggataa ctcttttgca tttagatcac atgagagcaa agactaaata      540

tgtcaaaatt gtggagaagt gggcttcaga tttaaggctg acaggaagac tgatgttcat      600

gggtaaaata atactgattt tactacaggg agacagaaac aacctcaagg agtacttgat      660

tcttcagaaa acctccaaag tagatgtgga ctcaagtgga aagaaatgca aagagaaaat      720

gattagtgta ctgtttgaaa caaaagtaca gacagaacac aaaaggtttc tggcatttga      780

agtcaaagag tattcagcgt tggatgaatt acaaaaggaa tttgaaactg caggacttaa      840

gaagcttttc tccgaatttg tacttgctct ggtaaaatga aatggaagac aggaatcttt      900

tagtaaaata gcagtgtttt ttgttgtttt tgcattggat ttggggagtg gttaattgaa      960

atagtcaatt ttaaagtttc tctgaagcaa aatgataggc atcattctaa cttcaggaac     1020

aaaagccagt tctgttttat gaaatattaa acatgaagaa aacttgtata ttctaatgtt     1080

tgccaggaaa ggctaggttc agtagatgag acattattta aaagataaat ttaaaaagat     1140

ggtaaatgaa cacttgtttt tatagacaat atttgtttga aactatgtaa ttttctggct     1200

aattttcttg taattaaatg attttttaaa aaaga                                1235


<210> 1728
<211> 5741
<212> DNA
<213> Homo sapiens

<400> 1728
gcggccgccg ccgcgccgtg gccctttgtg ctggaacaat gaccagctgc cgctggcccc       60

ggggccccgg ctggggttga gggtgaccac cgccgccgcc gcgtcgagcc gaaccgagcc      120

cccagacacg cagtcacagg gcgtcggagg gagggctccc gactgccgcc gagcagcccc      180

tacgtgcgcc ccggcggatt cgcgtgacgc gggtgcttgc gcgtgtccgc gccccggggc      240

ggagacgccc ctcggaccct cccctgcgcg gtgccgccca ctcgcaccgg gcgggggctg      300

gccagggccg ggggcgccgc ggaggcggag gcggggctgg gccgggcagc tccgagtggc      360

ggcgcgcggg ccagggccgg ggccggggcc ggggccggag ccggagccgg ggccgggcgg      420

cgcgcctgtg gagcgctggg ggcggcctgg ggctgagcat ggagcagcgc ggcggaggtg      480

aggggggccg ggtctgggag gcggcctggg gagcccccaa cttatgcgcg gtggaatcca      540

gccgggggga cggcgttccc cagtcgcccc cactttctgg aaggggggct ggactctgga      600

gaatgggtca ggggctcctg gcttcccgcc gcagaatggg aactcgtgat cgcagacttg      660

accccgcttg actggtcctt ggagtttggg tgggagggag actttcccca actcttcaga      720

tccgtctccg gccctgaacc agctccagcc ctctgctctc ctcagcccac taaaaggggg      780

gtgctcctgg gccagagtga ttgctcaggg agtgctgggg agaatgaggg gttcccatct      840

cccacagcca caaacgcatt tctcaaaatg gagcctccac ttgcccctcc ttctctttcg      900

ggctccaaga gcgggagccg gcctggctgg gcctggcttt ccagactcct ggctctggct      960

ccctggatgt gtggctctca gggcccggct ctgtggcact ttggacttat gggccctcgg     1020

ctccgtgggg ttggggggcc ctggctcact gggtcccgct ggctgtcccc ttgtcggcct     1080

gaccctcggg cctctccgag tctttgtctc ttttgggtcc ctgtctttct ctgagcctgt     1140

ctccttcctt caattttcac tttctccgtg ctcgctgaag tggggaaatg caacagaggt     1200

gccagccccc ttggccccct aagaagtccc ttccccactg ttcactccac accctggagt     1260

gggcccagag aggggagggg agggggttct ctatctgctc tgctgggggc tggggtgtgt     1320

ggggtggtct gagccccagc cctacagagg ggcctgtggt cactccctgc tcctggccta     1380

cccctccccc agctccccgc agctcctgcc ccagcgtgga cacctcttcc tggttcgcag     1440

tgtcttttga cttgggtggg aaggagggcg gtggatttaa tggagggcat gcgagaaaga     1500

aggggaacag atcaggcaaa ggagttagat aatgtcccac ctctccccac acgccgaaga     1560

gagaaggaaa caggctcccc ccaccaatgg gccctcaagc cacccaggct cccaccactc     1620

tcatacctgc gtgcccacgt tcacaggctc cactgcacca ctcaccttcc tagtcacaca     1680

caaacacagg agctcacaca taaactcatg aacttactga caagtctgtc caggcaccgt     1740

ctctcccaca caccacaaat tcacttgtta gatccacatt tataactttc acaggctttc     1800

taatgacccc tgatccacat actcttctaa gatatacaca tgtgaattca cacatgaact     1860

catatgtatg tgaatgaact gatatatcaa acatgcatag actcacatga tgttttcaca     1920

cacattttca tacacacgtg ttcattttca tgctcctgtg catgtagtca cacaacaaat     1980

aactaaatgc acacactcct actcccagtg caattctctg tccacttctt ggccccgctc     2040

tgcatgatga cttcagcaga tgcctaagtc ctggtcatca gcggcctcgg gactgggact     2100

agggaggggg ttccgggtgg aggcttgcag ctgcttccag gaaggagcag agcctgggga     2160

ggtggagccc tcttgcctgg gctctgtgga agtgaggttt tggagcagcc tccagaggtg     2220

aaggcagggc atctaccttc ctcccctcag ggttagtttg gggaccttct gaagctgtag     2280

ggtttcagag aggttggcag tggggcagag cctgtggagg ctccttcagg ccttcaggcc     2340

tcaccgattg ggtgtgcaga ggctaggagt tgtcatggaa actggtatga gcctgcatcc     2400

acctctggga ggcaggagac cccaaaggac acctgtggac tccctaagag ccgcgggttt     2460

cttatttagc cagatcgaca gagaggcagt ttagccgcct ttctgtctga gagaaactga     2520

ggcccagcag agggaggcag ggcactgcct ggccttggct ctttgttccc taattaccat     2580

ctgaggtgct gattgcaccc ctgaggtacc tctgcccaaa ctgccctgta atgaggccac     2640

ctggctgaga ggaccaggga cctgtgcttc aagctggtag agaaggcccc tccctcacct     2700

gagtcctggc ctctgtggag gatgcaggat tgggcttggg cctgggtctt tgctgccagg     2760

tggccctgcg gtaatcatcc aggcctccca tgcctctcag catctctgct gagtgaattc     2820

actcctcagc cctgttcaga ccagcattgg gcagtgtggt ttggggccca gggggaattg     2880

agattcattc cagcacttga agggggagtc ttggtgggga tcagggcttg ttactgatgt     2940

caaggaggtg tttggtcagg atcagtgggt caggaggggt ctcaaggtgg agggactctg     3000

acaccactgc cctgcttaca ggtcgcctgc gaggccgctg gccaggcctg agcctctgcc     3060

accatggcca ttgtgcagac tctgccagtg ccactggagc ctgctcctga agctgccact     3120

gccccacaag ctccagtcat gggtagtgtg agcagcctta tctcaggccg gccctgtccc     3180

ggggggccag ctcctccccg ccaccacggc cctcctgggc ccaccttctt ccgccagcag     3240

gatggcctgc tacggggtgg ctatgaggca caggagccgc tgtgcccagc tgtgccccct     3300

aggaaggctg tccctgtcac cagcttcacc tacatcaatg aggacttccg gacagagtca     3360

ccccccagcc caagcagtga tgttgaggat gcccgagagc agcgggcaca caatgcccac     3420

ctccgcggcc caccaccaaa gctcatccct gtctctggaa agctggagaa gaacatggag     3480

aagatcctga tccgcccaac agccttcaag ccagtgctgc ccaaacctcg aggggctccg     3540

tccctgccta gcttcatggg tcctcgggcc accgggctgt ctgggagcca gggcagcctg     3600

acgcagctgt ttgggggccc tgcctcctcc tcctcctctt cctcctcctc ttcagctgct     3660

gacaaacccc tggcatttag tggctgggcc agtggctgcc catcagggac gctatccgac     3720

tctggccgaa actcactgtc cagcctgccc acctacagca ccggaggtgc cgagccaacc     3780

accagctccc caggcgggca cctgccttcc catggctctg ggcgaggggc actgcctggg     3840

ccagcccgag gggtccctac tgggccctcc cactcagaca gtggccggtc ctcctccagc     3900

aagagcacag gctccctagg gggccgtgtg gctggggggc ttttgggcag tggtactcgg     3960

gcctcccctg acagcagctc ctgtggggag cgctcaccac cacccccgcc tccacctcct     4020

tcggatgagg ccctgctgca ctgtgtcctg gaaggaaagc tccgagaccg ggaggcagag     4080

cttcagcagc tgcgggacag tctggacgag aatgaggcta ccatgtgcca ggcatacgag     4140

gagcggcagc ggcactggca gcgagagcgt gaggccctgc gagaggactg tgcggcccag     4200

gcacagcggg cacagcgggc ccaacagctg ctgcagctgc aggtgttcca gctgcagcag     4260

gagaagcggc aattgcagga cgacttcgca cagctgctgc aggagcgcga acagctggag     4320

cggcgctgcg ccaccttgga gcgggagcag cgggagctcg ggccgaggct tgaggagacc     4380

aagtgggagg tgtgccagaa atcaggcgag atctccctgc tgaagcagca gctgaaagag     4440

tctcaggcag agctggtgca gaagggcagc gagctggtgg ctctgcgggt ggcgctgcgg     4500

gaggcccgtg ctacgctgcg ggtcagtgag ggccgtgcgc ggggtctaca ggaggccgcc     4560

cgagctcggg agctggagct ggaagcctgt tcccaggagc tgcagcgaca ccgccaggaa     4620

gctgagcagc tgcgggagaa agctgggcag ttggatgctg aggcggccgg actccgggag     4680

ccccctgtgc cacctgccac cgctgaccca ttcctcctgg cagagagtga tgaggccaaa     4740

gtgcagcggg cagcagccgg ggttgggggc agcttgcggg cccaggtgga gcgattgcgg     4800

gtggagctgc agcgggagcg gcggcggggt gaggagcagc gggacagctt tgagggggag     4860

cggctggcct ggcaggcaga gaaggagcag gtgatccgct accagaagca gctgcagcac     4920

aactacatcc agatgtaccg gcgcaaccgg cagctagagc aggagctgca gcagctcagc     4980

ctggagctgg aggcccggga gctcgctgac ctgggcctgg ccgagcaggc cccctgcatc     5040

tgcctggagg agatcactgc tactgagatc tagggccctc agcaaccagc tctgtaggga     5100

gctctgccag aggggcagca gctgcagatc cacttaggcc ccagggtcca cggatggccc     5160

caaaggctga gggccccaaa gccacttgtc tcctaggatc caggcctctg ggcttctgcc     5220

aagaactcag ggtggcccta tgacttggag gagcaagatc agaccgctca aaggtccccg     5280

tgttcactgt tacccagagg ctcttgttac tacccacttc attccccacc gctgccagtg     5340

ccactgccaa ccctgttcac aggcgcttcc agcccactcc agccagggga gcagggaaga     5400

agaaggggct ccctcctctt cacattcccc ccgaccccaa agccagagaa agccagatgg     5460

caccagctgc tccggatgtg cctgcccaca ttgggggaca gggccgggcc tgggctcggt     5520

tcccaggttt gagctctgca gcctctctcc tggagtgagg gggctgaagt cagaccaaag     5580

gaagaactca gaaatgtctt gtttatttgt gtttgtgacc aagcagcctc tcccttcacc     5640

caggtttatg gcctcgtttt cacttgtata tttttcacac tgtaaatttc ttgtacaaac     5700

ccaaagaaaa aattaaaaaa aatttttttg tttaaaaata a                         5741


<210> 1729
<211> 2883
<212> DNA
<213> Homo sapiens

<400> 1729
ccaggtcggg ccaggcgggc gccgggagct gggagccggg agcccagagt tcggaaccta       60

gagttcggag ccggctaggg agccggcgtt gtcgcggcga ggaggtgggc gcgctggagc      120

aggagcgggg ccggaactgg agccgaggcg caggtggcgc tgggtcgcct gcgaggccgc      180

tggccaggcc tgagcctctg ccaccatggc cattgtgcag actctgccag tgccactgga      240

gcctgctcct gaagctgcca ctgccccaca agctccagtc atgggtagtg tgagcagcct      300

tatctcaggc cggccctgtc ccggggggcc agctcctccc cgccaccacg gccctcctgg      360

gcccaccttc ttccgccagc aggatggcct gctacggggt ggctatgagg cacaggagcc      420

gctgtgccca gctgtgcccc ctaggaaggc tgtccctgtc accagcttca cctacatcaa      480

tgaggacttc cggacagagt caccccccag cccaagcagt gatgttgagg atgcccgaga      540

gcagcgggca cacaatgccc acctccgcgg cccaccacca aagctcatcc ctgtctctgg      600

aaagctggag aagaacatgg agaagatcct gatccgccca acagccttca agccagtgct      660

gcccaaacct cgaggggctc cgtccctgcc tagcttcatg ggtcctcggg ccaccgggct      720

gtctgggagc cagggcagcc tgacgcagct gtttgggggc cctgcctcct cctcctcctc      780

ttcctcctcc tcttcagctg ctgacaaacc cctggcattt agtggctggg ccagtggctg      840

cccatcaggg acgctatccg actctggccg aaactcactg tccagcctgc ccacctacag      900

caccggaggt gccgagccaa ccaccagctc cccaggcggg cacctgcctt cccatggctc      960

tgggcgaggg gcactgcctg ggccagcccg aggggtccct actgggccct cccactcaga     1020

cagtggccgg tcctcctcca gcaagagcac aggctcccta gggggccgtg tggctggggg     1080

gcttttgggc agtggtactc gggcctcccc tgacagcagc tcctgtgggg agcgctcacc     1140

accacccccg cctccacctc cttcggatga ggccctgctg cactgtgtcc tggaaggaaa     1200

gctccgagac cgggaggcag agcttcagca gctgcgggac agtctggacg agaatgaggc     1260

taccatgtgc caggcatacg aggagcggca gcggcactgg cagcgagagc gtgaggccct     1320

gcgagaggac tgtgcggccc aggcacagcg ggcacagcgg gcccaacagc tgctgcagct     1380

gcaggtgttc cagctgcagc aggagaagcg gcaattgcag gacgacttcg cacagctgct     1440

gcaggagcgc gaacagctgg agcggcgctg cgccaccttg gagcgggagc agcgggagct     1500

cgggccgagg cttgaggaga ccaagtggga ggtgtgccag aaatcaggcg agatctccct     1560

gctgaagcag cagctgaaag agtctcaggc agagctggtg cagaagggca gcgagctggt     1620

ggctctgcgg gtggcgctgc gggaggcccg tgctacgctg cgggtcagtg agggccgtgc     1680

gcggggtcta caggaggccg cccgagctcg ggagctggag ctggaagcct gttcccagga     1740

gctgcagcga caccgccagg aagctgagca gctgcgggag aaagctgggc agttggatgc     1800

tgaggcggcc ggactccggg agccccctgt gccacctgcc accgctgacc cattcctcct     1860

ggcagagagt gatgaggcca aagtgcagcg ggcagcagcc ggggttgggg gcagcttgcg     1920

ggcccaggtg gagcgattgc gggtggagct gcagcgggag cggcggcggg gtgaggagca     1980

gcgggacagc tttgaggggg agcggctggc ctggcaggca gagaaggagc aggtgatccg     2040

ctaccagaag cagctgcagc acaactacat ccagatgtac cggcgcaacc ggcagctaga     2100

gcaggagctg cagcagctca gcctggagct ggaggcccgg gagctcgctg acctgggcct     2160

ggccgagcag gccccctgca tctgcctgga ggagatcact gctactgaga tctagggccc     2220

tcagcaacca gctctgtagg gagctctgcc agaggggcag cagctgcaga tccacttagg     2280

ccccagggtc cacggatggc cccaaaggct gagggcccca aagccacttg tctcctagga     2340

tccaggcctc tgggcttctg ccaagaactc agggtggccc tatgacttgg aggagcaaga     2400

tcagaccgct caaaggtccc cgtgttcact gttacccaga ggctcttgtt actacccact     2460

tcattcccca ccgctgccag tgccactgcc aaccctgttc acaggcgctt ccagcccact     2520

ccagccaggg gagcagggaa gaagaagggg ctccctcctc ttcacattcc ccccgacccc     2580

aaagccagag aaagccagat ggcaccagct gctccggatg tgcctgccca cattggggga     2640

cagggccggg cctgggctcg gttcccaggt ttgagctctg cagcctctct cctggagtga     2700

gggggctgaa gtcagaccaa aggaagaact cagaaatgtc ttgtttattt gtgtttgtga     2760

ccaagcagcc tctcccttca cccaggttta tggcctcgtt ttcacttgta tatttttcac     2820

actgtaaatt tcttgtacaa acccaaagaa aaaattaaaa aaaatttttt tgtttaaaaa     2880

taa                                                                   2883


<210> 1730
<211> 1375
<212> DNA
<213> Homo sapiens

<400> 1730
agtgtctcgg gctcggcgcc cgcggagcgt gtttccgacg gtgccctgcc ggggtccgcg       60

ccgctttggt cctccgcagc cgccgtccac agcgcccggc tccgcgcgag agccctgcca      120

gaggagcggc tccggccgcc gcgcctgacc cttgtccggg gtcttccgca cagtgggctg      180

agggccatgt cagttttctg ccacctacag gatagaccat gaagctgaag gaacttgagc      240

ggccagctgt ccaggcatgg agcccagcca gccaataccc tttgtatctg gccacaggaa      300

catctgccca acagctagat tcctccttca gcacaaatgg cacattggaa atatttgagg      360

ttgatttcag ggacccttct ctggacttga aacacagagg agtcctttct gccttgagca      420

ggtttcacaa gctggtctgg gggagctttg gcagtgggct tctggaaagc tccggggtta      480

ttgttggcgg cggggacaat ggcatgctta ttctatacaa tgtgacccac atcctgtctt      540

cggggaagga gcctgtgatt gctcagaaac agaagcacac gggggctgtc agagccctcg      600

acttgaatcc tttccagggc aacctcctgg cttcaggggc cagcgattct gaaatcttca      660

tttgggatct gaataacttg aatgtgccaa tgaccctggg atccaagtca cagtatcatg      720

agcagcctcc agaggacatc aaggcactgt cttggaaccg gcaagcccaa cacattctgt      780

cttctgctca ccccagtggc aaggcagttg tgtgggatct caggaagaat gaacctatca      840

tcaaagtcag tgatcacagc aacaggatgc actgctcagg cctggcctgg catcctgaca      900

tagccaccca gttagtgctg tgctcagagg atgatcgact tcccgtgatt cagctgtggg      960

acttgcgctt tgcctcctcg cccttgaagg tgctggagag ccacagcagg gggatcttgt     1020

cagtgtcatg gagccaggct gatgctgagc tgctgctcac tagtgctaag gacagccaga     1080

tcttgtgccg gaacctgggg agcagtgagg tggtatataa gctaccaaca cagagcagct     1140

ggtgctttga tgtgcagtgg tgccctcggg acccttcagt gttctctgct gcctccttca     1200

acggctggat cagtttgtac tctgtgatgg gtaggagctg ggaagtccag catatgagac     1260

aggctgacaa ggtttgaagg gcttggtaga gaatgctgga gggaaggggc tgtctctgtt     1320

tgtgggagag agacatatgg cttgagaagc ggagatattg gagattggga gacca          1375


<210> 1731
<211> 4612
<212> DNA
<213> Homo sapiens

<400> 1731
gaggagcggc tccggccgcc gcgcctgacc cttgtccggg gtcttccgca cagtgggctg       60

agggccatgt cagttttctg ccacctacag gatagaccat gaagctgaag gaacttgagc      120

ggccagctgt ccaggcatgg agcccagcca gccaataccc tttgtatctg gccacaggaa      180

catctgccca acagctagat tcctccttca gcacaaatgg cacattggaa atatttgagg      240

ttgatttcag ggacccttct ctggacttga aacacagagg agtcctttct gccttgagca      300

ggtttcacaa gctggtctgg gggagctttg gcagtgggct tctggaaagc tccggggtta      360

ttgttggcgg cggggacaat ggcatgctta ttctatacaa tgtgacccac atcctgtctt      420

cggggaagga gcctgtgatt gctcagaaac agaagcacac gggggctgtc agagccctcg      480

acttgaatcc tttccagggc aacctcctgg cttcaggggc cagcgattct gaaatcttca      540

tttgggatct gaataacttg aatgtgccaa tgaccctggg atccaagtca cagcagcctc      600

cagaggacat caaggcactg tcttggaacc ggcaagccca acacattctg tcttctgctc      660

accccagtgg caaggcagtt gtgtgggatc tcaggaagaa tgaacctatc atcaaagtca      720

gtgatcacag caacaggatg cactgctcag gcctggcctg gcatcctgac atagccaccc      780

agttagtgct gtgctcagag gatgatcgac ttcccgtgat tcagctgtgg gacttgcgct      840

ttgcctcctc gcccttgaag gtgctggaga gccacagcag ggggatcttg tcagtgtcat      900

ggagccaggc tgatgctgag ctgctgctca ctagtgctaa ggacagccag atcttgtgcc      960

ggaacctggg gagcagtgag gtggtatata agctaccaac acagagcagc tggtgctttg     1020

atgtgcagtg gtgccctcgg gacccttcag tgttctctgc tgcctccttc aacggctgga     1080

tcagtttgta ctctgtgatg ggtaggagct gggaagtcca gcatatgaga caggctgaca     1140

agatctcctc ttccttcagc aaaggccagc ctctcccacc actgcaggtg ccagagcaag     1200

tggcacaagc accactgata cctcccctga aaaaaccccc caaatggatt agaagaccaa     1260

caggtgtttc atttgctttt ggagggaagc tggttacttt tggcctcccc agcacccctg     1320

cccatctggt gccacagcct tgcccccgcc tagtcttcat cagtcaagtc accacagaat     1380

ctgaattcct gatgcgatca gctgagctgc aggaggcctt gggatcagga aatctactga     1440

attactgtca gaacaagagc cagcaagctt tactgcaaag tgaaaagatg ctgtggcagt     1500

tcctgaaggt gaccttagag caagactcca gaatgaaatt cctaaagctt ttaggataca     1560

gtaaagatga gcttcagaag aaggtggcca catggttgaa gagtgacgtg gggctaggtg     1620

agagtcctca gcccaaggga aatgacctca acagtgacag acaacaggcc ttctgcagcc     1680

aggcctccaa acacaccaca aaggaagcct ctgcttcctc agccttcttt gatgagctgg     1740

tccctcagaa catgactcct tgggagatcc ccatcacaaa agatattgat ggactcctaa     1800

gccaggctct cctgcttggg gaactgggtc cggccgtgga gctgtgtctg aaggaggagc     1860

gctttgctga tgccattatc ctggcccagg ctgggggtac agatctgctg aagcaaacac     1920

aggagcgcta cttggccaag aagaaaacca aaatctcctc gcttctagcc tgtgttgtgc     1980

aaaagaattg gaaggatgtg gtgtgtacct gtagcctgaa gaactggaga gaggcactgg     2040

ctttgctact gacatactca ggcacagaga aatttcccga gctctgtgac atgctgggaa     2100

ctcgcatgga acaggagggc agcagggcac taacctccga agccagactc tgttatgtgt     2160

gctcagggag tgtggagcgg ctggtggagt gctgggcaaa atgccaccag gctttgtccc     2220

ccatggctct gcaggacctg atggagaagg tgatggttct taacaggagc ttggagcaac     2280

tgcggggtcc tcatggggtg agcccaggcc ctgccacaac ctacagggtc actcagtatg     2340

ccaacctcct ggcagcccag ggcagcctgg ccactgccat gagctttcta cccagggact     2400

gtgctcagcc accagttcag cagctaagag atcggctttt tcatgctcaa ggttctgctg     2460

tcttgggcca acagtctccc cctttcccct tcccccggat tgttgtggga gctaccctcc     2520

actctaaaga gacatcatct tacagattgg gatcccagcc ttctcaccag gtcccaactc     2580

catctccaag gccaagggtt ttcacccctc agtcatcacc agcgatgccc ttggcacctt     2640

cccatcctag cccttatcag ggtcccagga cacagaatat aagtgactac agggcacctg     2700

ggccccaggc catccagcct ttgcctttga gccctggggt aaggcctgct tcatctcagc     2760

cacagctatt aggagggcaa agggtgcaag ttcctaaccc ggtgggattc cctgggacat     2820

ggcctcttcc tggttcccct ctacccatgg catgcccagg catcatgcga cctggctcta     2880

cctccctgcc tgagactcct agactgttcc ctctgcttcc tctgagacca ctaggtcccg     2940

gccgcatggt ctcccacacc ccagcccctc ctgcaagctt ccctgtgcca taccttccag     3000

gggacccagg tgccccatgc tctagtgtcc tcccaaccac tggcatcttg actcctcacc     3060

caggacctca agattcctgg aaagaagccc cagcccccag gggaaacctc cagaggaaca     3120

agctgccaga gacatttatg cccccagcac caattactgc tccagttatg agcctcaccc     3180

ctgagctaca agggattctt ccctcacagc cccctgtctc cagtgtgagt catgctcccc     3240

caggagttcc aggagaactc agcctgcagc ttcagcacct gccacctgag aagatggaaa     3300

ggaaggagct gcccccagag catcagtcct tgaagagcag ctttgaggcg cttctccaac     3360

gctgctccct gtctgcaact gacttaaaga caaaaaggaa gctggaagag gcagcccagc     3420

gtctggagta tctatatgag aagctctgtg aggggacact ctcacctcat gtcgtggctg     3480

ggctccatga ggttgcccga tgtgtggatg caggaagctt tgagcagggc cttgcagtgc     3540

atgcccaggt ggcgggctgt agcagcttca gcgaggtgtc cagcttcatg cctatcctga     3600

aggctgtcct catcatcgct cataagctgc tggtctaaac caggcagcct ctcttgctag     3660

gaggccactt ctgctgttac ataactcctc cctgcagaag aggggacttc tgcaacagat     3720

tctgtttctt tttcccgact cttttccttg ctgccaggta tgtgatgctg taggcttggc     3780

tccaaaccag ctgagtgcct gctttttact cctttatgtc tggccttcta ggatctgtcc     3840

aagacactct caggcctgga ggcagggcat agaatcagtt cttcactctc cctaatacta     3900

cactctgtaa ggacctgggg caggatatct tctcccccag ggatcttcta tttaagtggc     3960

ttctgagagg gtgaacagga ttgttacttt taagcctacc tctgctgtga cccatcatgt     4020

gggtcttttg tttctccctt ctgtggttta tgagcctgcc cttacctttt ccctgcctct     4080

gacttggtat ttccaggtcc gtatttctct gtagcccagg gtctggggta gagctgactg     4140

ctgttcaccc tttgaacaac tcatggacgt gagggatggg tgctgagcag aaccaagaga     4200

ggaaactttg gcgctgttaa aatggaattt ctcatctgcc ggcattatta agggtgggct     4260

aggttggatg gaaggtgaaa gggatgaact gccttttgct ggaagctgtc ttaggctgtg     4320

agacaggagc aggggaacca cagcctatgg ggaactgccc ttgactccac ctatgttgga     4380

gccttagccc aaggccattc cttctgtgat gataaagccc agttctggaa ttggagccat     4440

attaaggaat gattctcttc cagcgctgct cctcaagggt tgggggtcct tctccctcgc     4500

agccaccaca tgtctcaggg ctaccttctc cgattggatt tgcatttgtg gcactgtctt     4560

tgatgcagtg atgtacttaa tggtgcaata aagctgcttc gatttggttt cc             4612


<210> 1732
<211> 2383
<212> DNA
<213> Homo sapiens

<400> 1732
gagcttactc cacgggaaca gcctctagat aatctgagtt gttgaaaata cgaagcctgt       60

tactcgtgaa cagtggctga caacagtgtt gttgtgagcc tggctgtctg cttggaccca      120

gaggtttcgt ctgccagggt ttttggttgt atttaggatt tcagggaaaa gtgtccaagc      180

tttcagtgtt ggagcaggta tggacgacaa aggcgacccg agcaatgagg aggcacctaa      240

ggccatcaaa cccaccagca aagagttcag gaaaacatgg ggttttcgaa ggaccactat      300

cgccaagcga gagggcgcag gggacgcgga ggctgaccca ctggagccgc cacccccaca      360

gcagcagctg ggcctgtccc tgcggcgcag tgggaggcag cccaagcgca ctgagcgcgt      420

ggagcagttc ctgaccattg cgcggcgccg cggcaggagg agcatgcctg tctccctgga      480

ggattctggt gagcccacgt cctgccccgc cacagacgcc gagacagcct ccgagggcag      540

cgtggaaagc gcttctgaga ccagaagcgg cccccagtct gcttccacag ctgtgaagga      600

acgaccagcc tcttctgaaa aggtgaaagg aggggatgac cacgatgaca cctccgatag      660

tgacagcgat ggcctgacct tgaaagagct tcagaatcgc cttcgcagga agcgggaaca      720

ggagcccact gagaggcccc tgaaagggat ccagagtcgc ctgcggaaga agcgccggga      780

ggagggtccc gccgagactg tgggctccga ggccagtgac actgtggagg gcgtcctgcc      840

cagtaagcag gagcccgaga acgatcaggg ggttgtgtcc caggctggga aagatgacag      900

agagagtaag ttggagggaa aggcggctca ggacatcaaa gatgaggagc ctggagactt      960

gggccgaccg aagcctgaat gtgagggtta cgaccccaac gccctgtatt gcatttgccg     1020

ccagcctcac aacaacaggt ttatgatttg ctgtgaccgc tgtgaagaat ggtttcatgg     1080

cgattgtgtg ggcatttctg aggctcgagg gaggcttttg gaaaggaatg gggaagacta     1140

tatctgccca aactgcacca ttctgcaagt gcaggatgag actcattcag aaacggcaga     1200

tcagcaggaa gctaaatgga gacctggaga tgctgatggc accgattgta caagtatagg     1260

aacaatagag cagaagtcta gcgaagacca agggataaag ggtagaattg agaaagctgc     1320

aaatccaagt ggcaagaaga aactcaagat cttccagcct gtgatagagg cgcctggtgc     1380

ctcaaaatgt attggccccg ggtgctgtca cgtggcgcag cccgactcgg tgtactgcag     1440

taatgactgt atcctcaaac acgccgcagc gacaatgaag tttctaagct caggtaaaga     1500

acagaagcca aagcctaaag aaaagatgaa gatgaagcca gagaagccca gtcttccgaa     1560

atgcggtgct caggcaggta ttaaaatctc ttctgtgcac aagagaccag ctccagaaaa     1620

aaaagagacc acagtgaaga aggcagtggt ggtccctgcg cggagtgaag cactcgggaa     1680

ggaagcagct tgtgagagca gcacgccgtc gtgggcgagc gatcacaatt acaatgcagt     1740

aaagccagaa aagactgctg ctccctcgcc gtcactgttg tataaatgct ctggtaagta     1800

ttcgtattct cttcatccca gtctgattgc atagccacac tgcccggcac gccacatcca     1860

cccctgtctg cacatgagtt gttctgacaa cagcgctgta tacgcttcag tttttccaca     1920

ttgtccacgg ccagcacatg aaagcatcac ttctttttta tgttgtggga atctttgcaa     1980

gttagtgttg catctgattt tcaggtgtac atttattttt gactgggcag ataggggatt     2040

tttttttttc catgtccgat tcacacgcta cacacccaca tgaacacatt cgaacttcga     2100

aggccacaca ctcctgcttc ataggcccca cggtaagtga gttcacacct agaacactgt     2160

cctgaccgca ggacgcgtgc cttggacttg gtattctaca tgtgactggc tttcttgccc     2220

tcgtctcttg aatgtttaga ctcttaagat catatcctgc cccaaatttc aaattaatga     2280

aatgaagata tttcaaacag atctttgaaa cctcagattc tgtggtgcaa ttttaatgtt     2340

ttcttgtttc tcagttttct gctataaaac tattttcaat tca                       2383


<210> 1733
<211> 2704
<212> DNA
<213> Homo sapiens

<400> 1733
ggggaaatgg ctgcgagacc ctagaggcct gcggagctta ctccacggga acagcctcta       60

gataatctga gttgttgaaa atacgaagcc tgttactcgt gaacagtggc tgacaacagt      120

gttgttgtga gcctggctgt ctgcttggac ccagaggttt cgtctgccag ggtttttggt      180

tgtatttagg atttcaggga aaagtgtcca agctttcagt gttggagcag gtatggacga      240

caaaggcgac ccgagcaatg aggaggcacc taaggccatc aaacccacca gcaaagagtt      300

caggaaaaca tggggttttc gaaggaccac tatcgccaag cgagagggcg caggggacgc      360

ggaggctgac ccactggagc cgccaccccc acagcagcag ctgggcctgt ccctgcggcg      420

cagtgggagg cagcccaagc gcactgagcg cgtggagcag ttcctgacca ttgcgcggcg      480

ccgcggcagg aggagcatgc ctgtctccct ggaggattct ggtgagccca cgtcctgccc      540

cgccacagac gccgagacag cctccgaggg cagcgtggaa agcgcttctg agaccagaag      600

cggcccccag tctgcttcca cagctgtgaa ggaacgacca gcctcttctg aaaaggtgaa      660

aggaggggat gaccacgatg acacctccga tagtgacagc gatggcctga ccttgaaaga      720

gcttcagaat cgccttcgca ggaagcggga acaggagccc actgagaggc ccctgaaagg      780

gatccagagt cgcctgcgga agaagcgccg ggaggagggt cccgccgaga ctgtgggctc      840

cgaggccagt gacactgtgg agggcgtcct gcccagtaag caggagcccg agaacgatca      900

gggggttgtg tcccaggctg ggaaagatga cagagagagt aagttggagg gaaaggcggc      960

tcaggacatc aaagatgagg agcctggaga cttgggccga ccgaagcctg aatgtgaggg     1020

ttacgacccc aacgccctgt attgcatttg ccgccagcct cacaacaaca ggtttatgat     1080

ttgctgtgac cgctgtgaag aatggtttca tggcgattgt gtgggcattt ctgaggctcg     1140

agggaggctt ttggaaagga atggggaaga ctatatctgc ccaaactgca ccattctgca     1200

agtgcaggat gagactcatt cagaaacggc agatcagcag gaagctaaat ggagacctgg     1260

agatgctgat ggcaccgatt gtacaagtat aggaacaata gagcagaagt ctagcgaaga     1320

ccaagggata aagggtagaa ttgagaaagc tgcaaatcca agtggcaaga agaaactcaa     1380

gatcttccag cctgtgatag aggcgcctgg tgcctcaaaa tgtattggcc ccgggtgctg     1440

tcacgtggcg cagcccgact cggtgtactg cagtaatgac tgtatcctca aacacgccgc     1500

agcgacaatg aagtttctaa gctcaggtaa agaacagaag ccaaagccta aagaaaagat     1560

gaagatgaag ccagagaagc ccagtcttcc gaaatgcggt gctcaggcag gtattaaaat     1620

ctcttctgtg cacaagagac cagctccaga aaaaaaagag accacagtga agaaggcagt     1680

ggtggtccct gcgcggagtg aagcactcgg gaaggaagca gcttgtgaga gcagcacgcc     1740

gtcgtgggcg agcgatcaca attacaatgc agtaaagcca gaaaagactg ctgctccctc     1800

gccgtcactg ttgtataaat gtatgtatca cctaggggtt ggcctcctgg acccctcccg     1860

ttctttctgg atagccatcc cctgggcctg tccaggactg ggagttgcag ctttgtgtta     1920

agctgatcac agacaccggc tgcaccatca gcgggaagca gagcccatgt ccaggatgcc     1980

tcctgctgcc ctgtgtccat ccctagtctg tcaggacttc ctgtcactgt tttccaaagc     2040

tgtaaacctc actggtgaac gttcacctta atgattgatt ctttaatctc tgttttcact     2100

ctcaggctct ggtaagtatt cgtattctct tcatcccagt ctgattgcat agccacactg     2160

cccggcacgc cacatccacc cctgtctgca catgagttgt tctgacaaca gcgctgtata     2220

cgcttcagtt tttccacatt gtccacggcc agcacatgaa agcatcactt cttttttatg     2280

ttgtgggaat ctttgcaagt tagtgttgca tctgattttc aggtgtacat ttatttttga     2340

ctgggcagat aggggatttt tttttttcca tgtccgattc acacgctaca cacccacatg     2400

aacacattcg aacttcgaag gccacacact cctgcttcat aggccccacg gtaagtgagt     2460

tcacacctag aacactgtcc tgaccgcagg acgcgtgcct tggacttggt attctacatg     2520

tgactggctt tcttgccctc gtctcttgaa tgtttagact cttaagatca tatcctgccc     2580

caaatttcaa attaatgaaa tgaagatatt tcaaacagat ctttgaaacc tcagattctg     2640

tggtgcaatt ttaatgtttt cttgtttctc agttttctgc tataaaacta ttttcaattc     2700

agtc                                                                  2704


<210> 1734
<211> 2833
<212> DNA
<213> Homo sapiens

<400> 1734
gtacttgcgc agaactcccc tcgcggcgac cacgcactac gggttggcgc cagagtcaaa       60

aggcgtcggc cctctggcaa gatggctgct gcggaggcgt tggagcgcgg aaatctggaa      120

ccgggatggc gacgtctaca ctgagtcgga ggcgaaggag cttactccac gggaacagcc      180

tctagataat ctgagttgtt gaaaatacga agcctgttac tcgtgaacag tggctgacaa      240

cagtgttgtt gtgagcctgg ctgtctgctt ggacccagag gtttcgtctg ccagggtttt      300

tggttgtatt taggatttca gggaaaagtg tccaagcttt cagtgttgga gcaggtatgg      360

acgacaaagg cgacccgagc aatgaggagg cacctaaggc catcaaaccc accagcaaag      420

agttcaggaa aacatggggt tttcgaagga ccactatcgc caagcgagag ggcgcagggg      480

acgcggaggc tgacccactg gagccgccac ccccacagca gcagctgggc ctgtccctgc      540

ggcgcagtgg gaggcagccc aagcgcactg agcgcgtgga gcagttcctg accattgcgc      600

ggcgccgcgg caggaggagc atgcctgtct ccctggagga ttctggtgag cccacgtcct      660

gccccgccac agacgccgag acagcctccg agggcagcgt ggaaagcgct tctgagacca      720

gaagcggccc ccagtctgct tccacagctg tgaaggaacg accagcctct tctgaaaagg      780

tgaaaggagg ggatgaccac gatgacacct ccgatagtga cagcgatggc ctgaccttga      840

aagagcttca gaatcgcctt cgcaggaagc gggaacagga gcccactgag aggcccctga      900

aagggatcca gagtcgcctg cggaagaagc gccgggagga gggtcccgcc gagactgtgg      960

gctccgaggc cagtgacact gtggagggcg tcctgcccag taagcaggag cccgagaacg     1020

atcagggggt tgtgtcccag gctgggaaag atgacagaga gagtaagttg gagggaaagg     1080

cggctcagga catcaaagat gaggagcctg gagacttggg ccgaccgaag cctgaatgtg     1140

agggttacga ccccaacgcc ctgtattgca tttgccgcca gcctcacaac aacaggttta     1200

tgatttgctg tgaccgctgt gaagaatggt ttcatggcga ttgtgtgggc atttctgagg     1260

ctcgagggag gcttttggaa aggaatgggg aagactatat ctgcccaaac tgcaccattc     1320

tgcaagtgca ggatgagact cattcagaaa cggcagatca gcaggaagct aaatggagac     1380

ctggagatgc tgatggcacc gattgtacaa gtataggaac aatagagcag aagtctagcg     1440

aagaccaagg gataaagggt agaattgaga aagctgcaaa tccaagtggc aagaagaaac     1500

tcaagatctt ccagcctgtg atagaggcgc ctggtgcctc aaaatgtatt ggccccgggt     1560

gctgtcacgt ggcgcagccc gactcggtgt actgcagtaa tgactgtatc ctcaaacacg     1620

ccgcagcgac aatgaagttt ctaagctcag gtaaagaaca gaagccaaag cctaaagaaa     1680

agatgaagat gaagccagag aagcccagtc ttccgaaatg cggtgctcag gcaggtatta     1740

aaatctcttc tgtgcacaag agaccagctc cagaaaaaaa agagaccaca gtgaagaagg     1800

cagtggtggt ccctgcgcgg agtgaagcac tcgggaagga agcagcttgt gagagcagca     1860

cgccgtcgtg ggcgagcgat cacaattaca atgcagtaaa gccagaaaag actgctgctc     1920

cctcgccgtc actgttgtat aaatgtatgt atcacctagg ggttggcctc ctggacccct     1980

cccgttcttt ctggatagcc atcccctggg cctgtccagg actgggagtt gcagctttgt     2040

gttaagctga tcacagacac cggctgcacc atcagcggga agcagagccc atgtccagga     2100

tgcctcctgc tgccctgtgt ccatccctag tctgtcagga cttcctgtca ctgttttcca     2160

aagctgtaaa cctcactggt gaacgttcac cttaatgatt gattctttaa tctctgtttt     2220

cactctcagg ctctggtaag tattcgtatt ctcttcatcc cagtctgatt gcatagccac     2280

actgcccggc acgccacatc cacccctgtc tgcacatgag ttgttctgac aacagcgctg     2340

tatacgcttc agtttttcca cattgtccac ggccagcaca tgaaagcatc acttcttttt     2400

tatgttgtgg gaatctttgc aagttagtgt tgcatctgat tttcaggtgt acatttattt     2460

ttgactgggc agatagggga tttttttttt tccatgtccg attcacacgc tacacaccca     2520

catgaacaca ttcgaacttc gaaggccaca cactcctgct tcataggccc cacggtaagt     2580

gagttcacac ctagaacact gtcctgaccg caggacgcgt gccttggact tggtattcta     2640

catgtgactg gctttcttgc cctcgtctct tgaatgttta gactcttaag atcatatcct     2700

gccccaaatt tcaaattaat gaaatgaaga tatttcaaac agatctttga aacctcagat     2760

tctgtggtgc aattttaatg ttttcttgtt tctcagtttt ctgctataaa actattttca     2820

attcagtctt taa                                                        2833


<210> 1735
<211> 1963
<212> DNA
<213> Homo sapiens

<400> 1735
ctgcctccga ctccccactg gactgcatgg cgacggcgtg tggtggggca gtcagctaag       60

ccatttgcct aaggggctgt cgggcatctg cgtgctgggg accgacagtg tgggtgtgtt      120

aggaggatct gtatggagca cattgctgcc tctggctagg acagggtgga aagggtggcg      180

tggctacagc ctgacccatg ggcaccgtcc taccctttgt tctgtgcttc cgagtgtcag      240

tcatgtgctg gggtctgtgg gcccatgact cagacggtga gctctgacct tcctgagcca      300

gggctttgct gtagttgtgc ctggctcagg agctctagga caaggggacc gctccaggtc      360

tgcatctacg gtgtggcagg gcccctcggc actcttgtgc actagtgtca tctttcccat      420

tgaaatgact gtgaggacca gaatgtgcac atgcagatgg gcagctactt gtctgccttg      480

gccctttatt acacaacttg ctgggggtgg agatgccacc ccccggcagt cagagcccct      540

ttatgatgtc atggggctgg ttacatgact gccaaggggt gctgctggcc acactgcact      600

agcaagtttg ccagatggag gacaagcgat cattgagtat ggctcgctgt gaagaaagaa      660

attcgagagg acaggatcat ggcttggaaa gggtgccttt ccctccccag ttgcagtcag      720

agacctacct tcacccagca gatccttccc ctgcctggga cgacccgggg tccactggga      780

gccctaactt gaggctgctg acagaagaaa tcgctttcca acctctggcc gaggaagctt      840

cgttcagaag gccgcaccct gacggtgacg tcccgcccca gggagaagat aatctcctct      900

ccctcccctt tccacagaaa ctgtggagac tggtcagcag caaccagttt tcgtccatct      960

ggtgggatga cagtggggct tgtagagtga tcaatcaaaa actctttgaa aaggagattc     1020

tcaaaaggga cgtcgcacac aaagtgtttg ccacaacttc gataaagagc ttcttccgcc     1080

agctaaactt gtatggcttc cgaaaacggc gtcaatgcac tttcaggacc ttcacccgca     1140

ttttctccgc aaaaaggctg gtctccatct tgaataagtt agagttctac tgccatcctt     1200

actttcaaag agactcccct cacctcctcg tgaggatgaa gagaagagtg ggtgtcaagt     1260

ctgcaccaag acatcaggag gaggacaagc cagaagctgc tggatcctgt ctggcaccag     1320

cagacactga gcaacaagat cacacgtctc cgaatgagaa tgaccaggtc acaccgcaac     1380

accgggaacc ggccggtccc aacacccaaa tcaggagtgg ctctgctcca ccagcaactc     1440

ctgtgatggt gcctgattcc gccgtggcga gtgacaacag tccagtgacc cagccggccg     1500

gcgagtggtc agagggcagc caggctcacg tcactccggt ggccgctgtc cctgggcctg     1560

cagcgctgcc cttcctctat gtccctggat ctcccactca gatgaattct tacgggcctg     1620

tggtggccct tcccacagcg tcccgtagta cccttgccat ggacaccaca ggacttcctg     1680

cacctggcat gctgcccttt tgccatctct gggtaccggt gaccctagtg gctgctgggg     1740

ctgcacagcc tgctgcctcc atggtcatgt tcccccatct cccagctctg caccaccatt     1800

gcccccacag ccaccgcacg tcacagtaca tgccagctag cgatgggccc caggcgtacc     1860

cagactacgc agaccagagc acatagaggg cagcatttgg gcagaatatg tgctggtcaa     1920

taaatgtgtc agaaaatgag taattttctg actgcacaaa aaa                       1963


<210> 1736
<211> 4172
<212> DNA
<213> Homo sapiens

<400> 1736
atgccgaccc tattcaaagg agtttggggg gttgtggagc attccagagc tctgggaaga       60

ttctgtcccg cctgcttacc ctcaggccca cacctccaca cacagccagc tctgggcact      120

gcagaaatga cgctcctctc ctcccagtct tcatcactgg tggccccttc tgggtctgtg      180

tctgccgaaa atccagagca gaggatgctg gagaagagag ccaaggtcat agaagaactt      240

cttcagacag aaagagacta cattcgggat ctggaaatgt gtattgagcg gatcatggta      300

cccatgcagc aggcacaggt accaaacatt gattttgagg gactttttgg aaatatgcag      360

atggtgatta aggtctcgaa gcaattattg gctgctctgg aaatcagcga tgctgtagga      420

cctgtgtttc ttggtcaccg ggatgagctt gagggaacat acaagattta ctgccagaat      480

catgatgagg ccattgcgct gcttgaaatc tacgagaagg atgagaagat ccagaagcat      540

cttcaggact ccttggcaga tctgaactct ttagttctaa aaaagggatg cacaaattat      600

attaacctgg gctccttcct catcaaacca gtacagagag taatgcgtta cccgctgttg      660

ctaatggagt tgctgaattc caccccagaa tcccacccag ataaagtgcc tttaaccaat      720

gcagtccttg cggtcaagga aatcaacgtt aacattaatg aatataaacg gcgaaaggac      780

ctggtcctca agtaccgtaa gggtgatgaa gatagcctta tggagaaaat ttccaaactg      840

aacatccact ccatcatcaa gaaatccaac cgagttagca gtcacctgaa gcatctcact      900

ggctttgctc ctcagataaa agatgaagta tttgaagaaa cagaaaaaaa cttccgaatg      960

caagaaagat tgattaagtc ttttatccga gacctgtctc tctacctcca gcacatccgg     1020

gagtccgcat gtgtgaaagt ggtggctgct gtgagcatgt gggatgtgtg catggagaga     1080

ggacaccggg acctggagca gtttgagagg gtgcatcgct acatcagtga ccagctcttc     1140

acaaacttta aggagaggac agagcggctt gtcatctccc ccttaaatca gttactgagc     1200

atgtttacag ggccccataa gctggtacag aaacgctttg acaagctcct ggacttctat     1260

aactgtacag aacgggcaga aaagctaaag gacaagaaga ccctggagga gctgcagtcg     1320

gcccggaaca actatgaggc cctgaatgca cagctgctgg atgagctgcc caagttccac     1380

cagtacgccc agggcctctt caccaactgt gtccacggct atgctgaagc ccactgtgac     1440

tttgtgcacc aggctctgga gcaattaaag ccactgcttt cgttactcaa agtggctggc     1500

agagagggaa accttattgc catcttccac gaagagcaca gcagagttct gcagcaactc     1560

caggttttta ccttcttccc ggagtctctt ccagctacca agaagccatt tgagaggaaa     1620

accattgacc gccagtctgc tcgaaagcca ctcctgggcc tgccaagtta catgctacag     1680

tcagaagaac tccgggcctc cctcctggcc aggtatcccc ctgaaaaact cttccaggca     1740

gaacggaact tcaatgctgc tcaagacttg gatgtctcac ttttggaagg tgacctggtg     1800

ggtgtgatta agaaaaaaga ccccatgggc agccagaacc gctggctgat tgacaatgga     1860

gtcaccaaag gcttcgtgta cagctctttc ctaaagccct acaatcctcg ccgcagccac     1920

tccgatgcct ccgtgggtag ccactcctcc acagagtctg agcacggcag ctcctccccc     1980

aggttcccac gccagaacag cggcagcacc ctgaccttca accccagcag catggctgta     2040

tcctttacct cggggtcttg ccagaagcag cctcaagatg catctcctcc gccaaaagaa     2100

tgtgaccaag gaactctcag tgcatcccta aatccgagta attcagagag tagtccttcc     2160

agatgccctt cagacccaga ctccacctcc cagccaaggt caggggactc tgcagatgta     2220

gctagagatg taaagcaacc cactgccacg ccgaggagct accggaactt caggcatcca     2280

gaaatagttg gctactccgt accaggacga aatgggcaaa gtcaagacct cgtcaaagga     2340

tgtgcaagaa cagcccaggc tccggaagac agaagtacag agccagatgg cagtgaggca     2400

gaaggcaacc aggtctattt tgctgtctac accttcaagg cacgaaaccc aaatgagctg     2460

agcgtgtcag ccaatcagaa actcaagatc ctcgagttta aagatgttac aggaaataca     2520

gagtggtggt tagctgaggt taacgggaag aagggctacg ttccctccaa ttatatccgc     2580

aaaaccgagt acacctgagc ccacgttgcc tgccacccag ccttgctgcc tttgctttca     2640

gtccgccgag ggttctggcg gcccaccgag agggcgcctg ctcctgagac acaggccctg     2700

tctgcgttgc ttaaccatgg catggtggag cacaccacag atcttgttct cctcgattgg     2760

gttgtaaacc ttgatgctca ctagaatctc tagaatttga aatggaccct ggggctttgc     2820

aaatgactta gtgactatga gaagagagac aagtcttaga gctggctttt ggaaaggaga     2880

aacttgcagt cagaagccca gtgtcctatg tatgcaggaa gctgtgctct agcaatagac     2940

agtgttggta atggttgtgc tgtacggcgt ttggggtggc cccatgttcc atgctcagct     3000

gaccggatgc caactcagat gaaaagaatt catggctctg ggcaccccgt gaggcagtgc     3060

ttgcacatgg ctgggagttt gtcgggattg aaccaaacct agtgcttcaa agctcctggg     3120

acacctccag tgtccagcac acattctcat acatactgcc cctaatttct aaagtcccta     3180

aagcactaca ttctgtaacc ttgtttcttt tactccattc ccagattagt tatgcaaaat     3240

tcaactgcgt tctactttta gaagtgttta gggtctttat tttctgttga cccttcatct     3300

gaaagattct cttcccttgt taggtacaat cactgccccc ccgctttttt ttttgagatg     3360

gggtcttgct atgttgccca ggctggtctt aaacgcctgg gctcaagcaa ccctcccgcc     3420

tccctgctga gattacaggt gtaagccacc ataccgcaac ctcaatgaca cctttctgat     3480

ggtctttaca cagtctgtga tgtctggtgg cccccctgcc ctggactcaa taattgatag     3540

attttcctag agtaacagta tgagagctcc agccattcca ttaaaagtat tagttctgct     3600

ttgagctgaa accagttgag cctaatggaa gactggatgt ctttcttctt catccaagca     3660

ccctaatgac tgtttagtta catccataga tgcagacaac ataacacctg tgacttactt     3720

gaattgggat aagccattcc agaagtagct tatcctagac ttggaaataa gatttttttc     3780

accactaact tccatgcttc agagatgaca ttcaaagcca gattcccaag tgcctgatca     3840

tacctcccag tctcaggaag atatttgctt accccttaga ccaagaatct taagatcttc     3900

cccagctatg aagcctatct tggaatggga aaccatgaaa tttgtctttt aaaagaaagg     3960

gaagaaatag ccttacagcc cctgttcctc caagtgcaca tttagcctta aaatcctggg     4020

agtcgggaga caccgtggag tcctaacatc cacagtgtct gctggtcgtg gtcagaaggc     4080

agtaatgcaa gagtcctttt gtgaagagtg tttctatgta gagatgttta tatttaagta     4140

gttcttttat aaataaaagc atttctaatg gc                                   4172


<210> 1737
<211> 4506
<212> DNA
<213> Homo sapiens

<400> 1737
actggagttc ctcaggccgc tctcctgaag cggtgctcag aggccctgac catcctgcca       60

ggcgcccgtg acccctgacc tcttccctct gcctcctgct gtggcttctg tccacaagcc      120

cctccccttc ccctttggac ccctcaggcc tccccagctg cctgcgctgg accctggcgg      180

ggctgtttca ctttttcctg ggcagtgtca tgtatgcacc tgtgggctga ctgtgtggcc      240

acatccagtc aggacccagc ctccagaact gacccaggga ggctcccgct ggccccagga      300

aggagaagta gaaactgatg atcaggcggg gcgagagaac cacaccagcg gccctgttga      360

gaaatcaggc cgagaggtcg gtggcggtgg ctcaggcctg taatcccagc actttcggag      420

gcctgggcag tcggatcacc agaggtcagg agtccaagat tagcctggcc aacatggtga      480

aactgttgtc tctactaaaa atacaacatt agccaggcgt gatgggcacc tgtaatccca      540

gttcctccag agattgaagc aggagaatcg cttaaacctg ggaggtggag gttgcagtga      600

gtggagattg cctgggaggt ggaggttgca gtgagtggag attgcctggg aggtggagat      660

tgcatgaagc tccatctcga ggggaaaaaa ataagaaaga aaaatcaggc agagaggcaa      720

cgccaggtcc cagctggagc tcagcgggga gccaggggat acagtggctg accgggcctc      780

ctaacccccc ttctagcact cccccaggat cctgggtccc aattgttgcc ctggacaaat      840

acgcccattc ctgccctacc caccgagtga ggctcagccc caggcccccc accctcatca      900

caaggtcagg gctgtgtccc accatcctca tcactaggta cttccggccc tttgctcagc      960

cccatgatgc ttggcctgca gagatggggg ctgaagggct tggggcatca aggggacctg     1020

acatcttgct gagaagccat cactagacag ggctggaggc tggagactca gggcctgccc     1080

tcaccgtggc cagtgaggcg tggggttggg cagggaaggg gcattcattc attagaccct     1140

gccagaagca cctgggtccc cttctggggc tacaggtggt gaggccactg cccccaagaa     1200

cacagcctgg tgactttagt gtacaaagca gggggagtct ccaggggcac agaacagagg     1260

ctaaagccag ggtggaggtg gccagcaggc ctaggaggag gagagggtca gggccacacc     1320

ccaggggagg tgcatgtcag ccaggggcca ccctaaggtg gaagccagga gtcccaaagg     1380

ggcctagaga aggagcagcc ccccacctgg ctaccgcagc cctctctggt tctgtgcagg     1440

gtattgggat gcgttactga ggcccaaatc tgccccactg ggaaccccca aaaaagagcc     1500

agggcaggag aatgagaggg aggagccatg aaacccccgc cctttaaaga cagctctgtg     1560

gcagctggcc caggccctgc agccctcacc acgttgggac tcacttgggg gtctcccatg     1620

ggggtcctaa tcccatctct tttcttccca gtccagaatg acagggtcca gaaactggcg     1680

agccacgagg gacatgtgta ggtatcggca caactatccg gtacgtacct gcccctgccc     1740

cgggacacag aaccctcccg ccagctgctc ttctcaggca gaatgtccca ggttctactg     1800

gaaggctggc ctggcttgct gtgccagggc cacagttctg ggcaggaccc tgcctggggc     1860

acagcctggt atagattcag agccctgccc ttcccctctc gcgggagacc gggggcatcc     1920

ccctactttt ctgagcttca gcacaccgtc gccttgcaaa catggccata gtgccagcct     1980

cgtgatgcac acgtgtgggg tccgtgatac cgcccacaca gcaccccacc cccatgccag     2040

ccctgtctcc tgcaggttgt cctcagccat taccctccac acccctgaat cacggaaacc     2100

cctgtgctgc cttcagggtg ctgaggaggg gacctgccag gcctggcctg gctggcgaaa     2160

tggggaaggg gggtccctgg ggcttggagg cagctgctgt cctctgaatg gcccccacct     2220

gcagagtgag gagccaggcg ggctcttggg gtattgggcc agcctggagg tttgcagatg     2280

cgcctccccg aaagacacgg agggccccag ggcagcttgt gtctgatgga tccctgctgt     2340

cccctttctc tggctcttca ggatctggtg gaacgagact gcaatgggga cacgccaaac     2400

ctgagtttct acagaaatga gatccgcttc ctgcccaacg gctgtttcat tgaggacatt     2460

cttcagaact ggacggacaa ctatgacctc cttgaggaca atcactccta catccagtgg     2520

ctgtttcctc tgcgagaacc aggagtgaac tggcatgcca agcccctcac gctcagggag     2580

gtcgaggtgt ttaaaagctc ccaggagatc caggagcggc ttgtccgggc ctacgagctc     2640

atgctgggct tctacgggat ccggctggag gaccgaggca cgggcacggt gggccgagca     2700

cagaactacc agaagcgctt ccagaacctg aactggcgca gccacaacaa cctccgcatc     2760

acacgcatcc tcaagtcgct gggtgagctg ggcctcgagc acttccaggc gccgctggtc     2820

cgcttcttcc tggaggagac gctggtgcgg cgggagctgc cgggggtgcg gcagagtgcc     2880

ctggactact tcatgttcgc cgtgcgctgc cgacaccagc gccgccagct ggtgcacttc     2940

gcctgggagc acttccggcc ccgctgcaag ttcgtctggg ggccccaaga caagctgcgg     3000

aggttcaagc ccagctctct gccccatccg ctcgagggct ccaggaaggt ggaggaggaa     3060

ggaagccccg gggaccccga ccacgaggcc agcacccagg gtcggacctg tgggccagag     3120

catagcaagg gtgggggcag ggtggacgag gggccccagc cacggagcgt ggagccccag     3180

gatgcgggac ccctggagag gagccagggg gatgaggcag ggggccacgg ggaagatagg     3240

ccggagccct taagccccaa agagagcaag aagaggaagc tggagctgag ccggcgggag     3300

cagccgccca cagagccagg ccctcagagt gcctcagagg tggagaagat cgctctgaat     3360

ttggaggggt gtgccctcag ccagggcagc ctcaggacgg ggacccagga agtgggcggt     3420

caggaccctg gggaggcagt gcagccctgc cgccaacccc tgggagccag ggtggccgac     3480

aaggtgagga agcggaggaa ggtggatgag ggtgctgggg acagtgctgc ggtggccagt     3540

ggtggtgccc agaccttggc ccttgccggg tcccctgccc catcggggca ccccaaggct     3600

ggacacagtg agaacggggt tgaggaggac acagaaggtc gaacggggcc caaagaaggt     3660

acccctggga gcccatcgga gaccccaggc cccagcccag caggacctgc aggggacgag     3720

ccagccgaga gcccatcgga gaccccaggc ccccgcccag caggacctgc aggggacgag     3780

ccagccgaga gcccatcgga gaccccaggc ccccgcccgg caggacctgc aggggacgag     3840

ccagccgaga gcccatcgga gaccccaggc cccagcccgg caggacctac aagggatgag     3900

ccagccgaga gcccatcgga gaccccaggc ccccgcccgg caggacctgc aggggacgag     3960

ccagccgaga gcccatcgga gaccccaggc ccccgcccgg caggacctgc aggggacgag     4020

ccagccgaga gcccatcgga gaccccaggc cccagcccgg caggacctac aagggatgag     4080

ccagccaagg cgggggaggc agcagagttg caggacgcag aggtggagtc ttctgccaag     4140

tctgggaagc cttaaggaaa ggagtgcccg tcggcgtctt ggtcctcctg tccctgctgc     4200

aggggctggg gcctccggag ctgctgcggg ctcccctcag gctctgcttc gtgacccgtg     4260

acccatgacc cacagtgctg gcctcctgtg gggccactat agcagccacc agaagccgcg     4320

aggccctcag ggaagcccaa ggcctgcaga agcctcctgg cctggctgtg tcttccccac     4380

ccagctctcc cctgcgcccc tgtctttgta aattgaccct tctggagtgg ggggcggcgg     4440

gcagggctgc ttttcttagt ctgataccaa gcaaggcctt ttctgaataa attcatttga     4500

ctttga                                                                4506


<210> 1738
<211> 1663
<212> DNA
<213> Homo sapiens

<400> 1738
agcgcgagcc ccgccgccgc cgagcatgga cgaccccgac tgcgactcca cctgggagga       60

ggacgaggag gatgcggagg acgcggagga cgaggactgc gaggacggcg aggccgccgg      120

cgcgagggac gcggacgcag gggacgagga cgaggagtcg gaggagccgc gggcggcgcg      180

gcccagctcg ttccagtcca gaatgacagg gtccagaaac tggcgagcca cgagggacat      240

gtgtaggtat cggcacaact atccggatct ggtggaacga gactgcaatg gggacacgcc      300

aaacctgagt ttctacagaa atgagatccg cttcctgccc aacggctgtt tcattgagga      360

cattcttcag aactggacgg acaactatga cctccttgag gacaatcact cctacatcca      420

gtggctgttt cctctgcgag aaccaggagt gaactggcat gccaagcccc tcacgctcag      480

ggaggtcgag gtgtttaaaa gctcccagga gatccaggag cggcttgtcc gggcctacga      540

gctcatgctg ggcttctacg ggatccggct ggaggaccga ggcacgggca cggtgggccg      600

agcacagaac taccagaagc gcttccagaa cctgaactgg cgcagccaca acaacctccg      660

catcacacgc atcctcaagt cgctgggtga gctgggcctc gagcacttcc aggcgccgct      720

ggtccgcttc ttcctggagg agacgctggt gcggcgggag ctgccggggg tgcggcagag      780

tgccctggac tacttcatgt tcgccgtgcg ctgccgacac cagcgccgcc agctggtgca      840

cttcgcctgg gagcacttcc ggccccgctg caagttcgtc tgggggcccc aagacaagct      900

gcggaggttc aagcccagct ctctgcccca tccgctcgag ggctccagga aggtggagga      960

ggaaggaagc cccggggacc ccgaccacga ggccagcacc cagggtcgga cctgtgggcc     1020

agagcatagc aagggtgggg gcagggtgga cgaggggccc cagccacgga gcgtggagcc     1080

ccaggatgcg ggacccctgg agaggagcca gggggatgag gcagggggcc acggggaaga     1140

taggccggag cccttaagcc ccaaagagag caagaagagg aagctggagc tgagccggcg     1200

ggagcagccg cccacagagc caggccctca gagtgcctca gaggtggaga agatcgctct     1260

gaatttggag gggtgtgccc tcagccaggg cagcctcagg acggggaccc aggaagtggg     1320

cggtcaggac cctggggagt cctcctgtcc ctgctgcagg ggctggggcc tccggagctg     1380

ctgcgggctc ccctcaggct ctgcttcgtg acccgtgacc catgacccac agtgctggcc     1440

tcctgtgggg ccactatagc agccaccaga agccgcgagg ccctcaggga agcccaaggc     1500

ctgcagaagc ctcctggcct ggctgtgtct tccccaccca gctctcccct gcgcccctgt     1560

ctttgtaaat tgacccttct ggagtggggg gcggcgggca gggctgcttt tcttagtctg     1620

ataccaagca aggccttttc tgaataaatt catttgactt tga                       1663


<210> 1739
<211> 1997
<212> DNA
<213> Homo sapiens

<400> 1739
agcgcgagcc ccgccgccgc cgagcatgga cgaccccgac tgcgactcca cctgggagga       60

ggacgaggag gatgcggagg acgcggagga cgaggactgc gaggacggcg aggccgccgg      120

cgcgagggac gcggacgcag gggacgagga cgaggagtcg gaggagccgc gggcggcgcg      180

gcccagctcg ttccagtcca gaatgacagg gtccagaaac tggcgagcca cgagggacat      240

gtgtaggtat cggcacaact atccggatct ggtggaacga gactgcaatg gggacacgcc      300

aaacctgagt ttctacagaa atgagatccg cttcctgccc aacggctgtt tcattgagga      360

cattcttcag aactggacgg acaactatga cctccttgag gacaatcact cctacatcca      420

gtggctgttt cctctgcgag aaccaggagt gaactggcat gccaagcccc tcacgctcag      480

ggaggtcgag gtgtttaaaa gctcccagga gatccaggag cggcttgtcc gggcctacga      540

gctcatgctg ggcttctacg atccggctgg aggaccgagg cacgggcacg gtgggccgag      600

cacagaacta ccagaagcgc ttccagaacc tgaactggcg cagccacaac aacctccgca      660

tcacacgcat cctcaagtcg ctgggtgagc tgggcctcga gcacttccag gcgccgctgg      720

tccgcttctt cctggaggag acgctggtgc ggcgggagct gccgggggtg cggcagagtg      780

ccctggacta cttcatgttc gccgtgcgct gccgacacca gcgccgccag ctggtgcact      840

tcgcctggga gcacttccgg ccccgctgca agttcgtctg ggggccccaa gacaagctgc      900

ggaggttcaa gcccagctct ctgccccatc cgctcgaggg ctccaggaag gtggaggagg      960

aaggaagccc cggggacccc gaccacgagg ccagcaccca gggtcggacc tgtgggccag     1020

agcatagcaa gggtgggggc agggtggacg aggggcccca gccacggagc gtggagcccc     1080

aggatgcggg acccctggag aggagccagg gggatgaggc agggggccac ggggaagata     1140

ggccggagcc cttaagcccc aaagagagca agaagaggaa gctggagctg agccggcggg     1200

agcagccgcc cacagagcca ggccctcaga gtgcctcaga ggtggagaag atcgctctga     1260

atttggaggg gtgtgccctc agccagggca gcctcaggac ggggacccag gaagtgggcg     1320

gtcaggaccc tggggaggca gtgcagccct gccgccaacc cctgggagcc agggtggccg     1380

acaaggtgag gaagcggagg aaggtggatg agggtgctgg ggacagtgct gcggtggcca     1440

gtggtggtgc ccagaccttg gcccttgccg ggtcccctgc cccatcgggg caccccaagg     1500

ctggacacag tgagaacggg gttgaggagg acacagaagg tcgaacgggg cccaaagaag     1560

gtacccctgg gagcccatcg gagaccccag gccccagccc agcaggacct gcaggggacg     1620

agccagccga gagcccatcg gagaccccag gcccccgccc ggcaggacct gcaggggacg     1680

agccagccga gagcccatcg gagaccccag gccccagccc ggcaggacct acaagggatg     1740

agccagccga gagcccatcg gagaccccag gcccccgccc ggcaggacct gcaggggacg     1800

agccagccga gagcccatcg gagaccccag gcccccgccc ggcaggacct gcaggggacg     1860

agccagccga gagcccatcg gagaccccag gccccagccc ggcaggacct acaagggatg     1920

agccagccaa ggcgggggag gcagcagagt tgcaggacgc agaggtggag tcttctgcca     1980

agtctgggaa gccttaa                                                    1997


<210> 1740
<211> 469
<212> DNA
<213> Homo sapiens

<400> 1740
gtcaccagga gggtatgcat agggagggca agagctctgg gccactgcga agattcaaaa       60

gctccaaaaa cctactgtag acatcgaaga accaatatat acaatgggcc aacaatccag      120

tgtccgcagg ctgaagagga gcgtcccctg tgaatccaac gaggccaacg aggccaatga      180

ggccaacaag acgatgccgg agaccccaac tggggactca gacccgcaac ctgctcctaa      240

aaaaatgaaa acatctgagt cctcgaccat actagtggtt cgctacagga ggaacgtgaa      300

aagaacatct ccagaggaac tggtgaatga ccacgcccga gagaacagaa tcaaccccga      360

ccaaatggag gaggaggaat tcatagaaat aacgactgaa agacctaaaa agtagcaaga      420

agctacatcc ctcaaacttc ggcaatgaaa ataaagtttg agaagctga                  469


<210> 1741
<211> 4070
<212> DNA
<213> Homo sapiens

<400> 1741
gggtggggcc gccgttgcca gagaagccac tagccggtta ctagctgcgc ttttgttcca       60

cttgagcggg cactcttctg cggcaagcag gtctaggaat tcgcctggtt cccacctcgc      120

gtcccttgcc ttccttccta gtctacccac tgtagtgccc cctgcgtccc gctccctcct      180

agccgactca gagcacaaga aggattgcca cggtttccat tgcagcagcc gtggcgcctc      240

tgaccctttt tttatatcgc ggcgacggcg ggctgtcgtc acgacgacgt gcggacgcag      300

cggcgggggc ctttcagctt atgtggagaa gtcgctgtga agccacctat aaatccattt      360

actgaattta tggagaaggc tgtaaatgat ggaagtcatt cagaagaact cttttgccat      420

cttaaaacta tatcagagaa agaagattta ccacggtgta ccagtgaaag tcatctcagc      480

tgcctgaagc aggacattct aaatgaaaag actgaattgg aagcaacact taaggaagcg      540

gagttggtaa ctcattctgt agaattgctt ttgccactat ttaaggacac cattgaaaag      600

attaattttg aaaatgcgaa tctttctgca ttgaatttga agatttctga acagaaggaa      660

atattaataa aagaattaga caccttcaaa agtgtaaaac tagctttaga acatcttctt      720

agaaagagag actacaaaca aacaggagac aatttatcca gcatgttgct agaaaatcta      780

actgataatg aaagtgaaaa tactaatctt aagaagaagg tatttgaaaa ggaggcccat      840

atccaagaac tttcttgttt gtttcagagt gaaaaggcaa atactttgaa agcaaaccgt      900

ttttcccaat cagtaaaagt agtacatgaa cgactacaga tccaaattca taaaagggaa      960

gccgagaacg ataagttgaa agaatatgta aagagcttag aaaccaagat agccaagtgg     1020

aacctgcaat caagaatgaa taagaatgag gctatagtga tgaaagaagc aagtaggcaa     1080

aaaactgtag ctttaaaaaa ggcatctaaa gtttacaaac aaaggcttga ccattttaca     1140

ggagctattg aaaagcttac ttcccaaatt agagatcagg aagccaagtt gtctgaaaca     1200

atttcagctt ccaatgcctg gaaaagtcat tatgagaaaa ttgtgataga aaaaaccgaa     1260

ttggaagtac agattgaaac aatgaaaaag caaatcatta atcttttgga agatctgaag     1320

aaaatggaag accatggaaa aaattcatgt gaagaaattc ttagaaaagt tcactcaatt     1380

gaatatgaaa atgaaactct gaatcttgag aatacaaaat taaagactac acttgctgct     1440

ttgaaggatg aagttgtatc tgttgaaaat gaactctcag aattgcaaga agtagaaaaa     1500

aaacagaaaa cccttattga aatgtataaa actcaggtac aaaagttgca agaagcagct     1560

gaaatagtaa aaagcagatg tgaaaatttg ctacataaaa ataaccaaat aacaaaaacc     1620

aaaaataaaa atgtagagaa ggttgatgga aatcacaatc ttctgacaaa gctttctctg     1680

gaagaggaaa actgtcttat tcagctgaag tgtgaaaacc ttcaacaaaa attagaacag     1740

atggacgcag aaaataaaga gcttgagaag aagctggcaa accaagaaga atgtcttaag     1800

cacagcaatc ttaagtttaa agagaaatct gcagagtata cagcattggc cagacaactg     1860

gaagctgctt tagaagaagg aagacaaaag gttgctgaag aaatagagaa aatgtcatct     1920

agagagagtg ctttacaaat taaaatatta gatctggaaa ctgagcttag aaagaaaaat     1980

gaagaacaaa atcaacttgt ttgcaaaatg aacagtaaag cacaacatca ggaagtgtgt     2040

ttgaaagaag tacaaaatag tcttgagaag tcggaaaatc aaaatgagag tattaagaat     2100

tatttacagt ttcttaaaac ttcttatgta acaatgtttg aataaattgt caaatttatt     2160

ttctctaagt agtagatttt tattatgagt ctaaaatgtg attgggtaaa aaaataaata     2220

tactaccagt tacattttat gatttatgag tggtagtatt agaggttttt atgtaaagat     2280

ttttgaaaca taatttatct aactgaaact ttaaaatagg atagttgtta ctattcctgt     2340

ttgctggata attcttattt atctttggtt taatttcttt taaaattaaa ttggttgtta     2400

gaatattttt ctcacacata gacatggaag tcagattcat tctttgtgat gtttgtagcc     2460

accattcaag tgaatttgta gtaagtcttg gtcaatatga ttttaaataa tatatataat     2520

tgttttatat tatgatatat aaatgtaaaa tattctgaat tttaattttt aataatggtg     2580

taattacata ctttctaaag ctactaaatg tctcaatata ctacacttaa tattgtttca     2640

agtatatgct gagttgccat tataatttct gttaggtttt aagtatacaa ttttaaatca     2700

tcgctattaa gtaccaactg ctaatgacag atgaaaacgt ggtcatgcat tatttcttta     2760

taaagaatag atattcaggc tgtcttcaat ttgtactctc ttttattcgt tttatactaa     2820

tgattatctg atattattat tattttagac attctagagc cccttagtta aataaaagat     2880

taaaggggaa cagcttatcc caccctttcc atggccaact catggggatg atcaaaataa     2940

gcactcttaa catcaagaag ctttaaaata aggtctttag tattgggata aagttgtcca     3000

agttgaaaaa gaacttgttt gctataatct cccactgtgt gtgccaaggc aggatactct     3060

aaaaggggat gacgtggttt acaaaggatc aagtaatagt gactcctctt ggacaatgac     3120

ttgagagctg ttaattcaga ggaacactca ggtcttaaaa gatcactaaa aaaggcaggt     3180

tgtgaactac acagttccag cctatgaaca gaaatatctc tttaagatgt tttatgcttt     3240

ttttctgatc agagatgggg gcctggtccc ctctgatccc ctcactttta agactgtcat     3300

atcattcaca gatgcttact ttctagtgat ccagttggtt cgtagtattt ttcttaaaat     3360

agcaaaatac agagtgtcag aactggccac attttttacc caacaattgc taacaagatt     3420

agtgtcattt taaaaaaaat cttagtactc atcatactaa aaacatgctt gacccttgca     3480

gccctttctt tacctcctaa tgcaaaggga gccttaaatg cccacatgaa aggaaagcaa     3540

agctcttgag ttttactcac taaactgtaa gctccttaag ggccgaaatg tatcttagtc     3600

atataaatat ctgggcactc agttgatgtt tgtggataga tggacagatg ttgaaagagg     3660

caggtattcg tactcctgtt ttagatatga aaaatgtaag caaaaaggat taattaccat     3720

ggctgtggta tgaaacttgt ttaaagttgg catttaaatt caagtctgca acattaaagt     3780

tctgtgtaca gagccgtttt cccactgtag cagcagcgca gcagcagcgc tgctatgatt     3840

gattaagcac ttgctatgtg ccagagttaa taattgtgat aatatattaa ctcatttaat     3900

tttcaggaaa ctaagacatg gaaaggttag gtaacttgcc caaggtcgca cagctagtaa     3960

gtggcagaca tccagagtct ctgctctgct cttaactctc accatactac ctctgtatcc     4020

atttcataaa taaagatagt agtttcttat aacagtaatg catttgtctt                4070


<210> 1742
<211> 2294
<212> DNA
<213> Homo sapiens

<400> 1742
gaagccacta gccggttact agctgcgctt ttgttccact tgagcgggca ctcttctgcg       60

gcaagcaggt ctaggaattc gcctggttcc cacctcgcgt cccttgcctt ccttcctagt      120

ctacccactg tagtgccccc tgcgtcccgc tccctcctag ccgactcaga gcacaagaag      180

gattgccacg gtttccattg cagcagccgt ggcgcctctg accctttttt tatatcgcgg      240

cgacggcggg ctgtcgtcac gacgacgtgc ggacgcagcg gcgggggcct ttcagcttat      300

gtggagaagt cgctgtgaag ccacctataa atccatttac tgaatttatg gagaaggctg      360

taaatgatgg aagtcattca gaagaactct tttgccatct taaaactata tcagagaaag      420

aagatttacc acggtgtacc agtgaaagtc atctcagctg cctgaagcag gacattctaa      480

atgaaaagac tgaattggaa gcaacactta aggaagcgga gttggtaact cattctgtag      540

aattgctttt gccactattt aaggacacca ttgaaaagat taattttgaa aatgcgaatc      600

tttctgcatt gaatttgaag atttctgaac agaaggaaat attaataaaa gaattagaca      660

ccttcaaaag tgtaaaacta gctttagaac atcttcttag aaagagagac tacaaacaaa      720

caggagacaa tttatccagc atgttgctag aaaatctaac tgataatgaa agtgaaaata      780

ctaatcttaa gaagaaggta tttgaaaagg aggcccatat ccaagaactt tcttgtttgt      840

ttcagagtga aaaggcaaat actttgaaag caaaccgttt ttcccaatca gtaaaagtag      900

tacatgaacg actacagatc caaattcata aaagggaagc cgagaacgat aagttgaaag      960

aatatgtaaa gagcttagaa accaagatag ccaagtggaa cctgcaatca agaatgaata     1020

agaatgaggc tatagtgatg aaagaagcaa gtaggcaaaa aactgtagct ttaaaaaagg     1080

catctaaagt ttacaaacaa aggcttgacc attttacagg agctattgaa aagcttactt     1140

cccaaattag agatcaggaa gccaagttgt ctgaaacaat ttcagcttcc aatgcctgga     1200

aaagtcatta tgagaaaatt gtgatagaaa aaaccgaatt ggaagtacag attgaaacaa     1260

tgaaaaagca aatcattaat cttttggaag atctgaagaa aatggaagac catggaaaaa     1320

attcatgtga agaaattctt agaaaagttc actcaattga atatgaaaat gaaactctga     1380

atcttgagaa tacaaaatta aagactacac ttgctgcttt gaaggatgaa gttgtatctg     1440

ttgaaaatga actctcagaa ttgcaagaag tagaaaaaaa acagaaaacc cttattgaaa     1500

tgtataaaac tcaggtacaa aagttgcaag aagcagctga aatagtaaaa agcagatgtg     1560

aaaatttgct acataaaaat aaccaaataa caaaaaccaa aaataaaaat gtagagaaga     1620

tgagaggcca gatggagtct catctgaagg agttagagcg tgtctgcgat tccttgacgg     1680

cggcggaacg gaggcttcac gagtgtcagg agagtctgca gtgctgcaag gggaagtgtg     1740

cagaccagga acacaccatt agggagcttc agggccaggt tgatggaaat cacaatcttc     1800

tgacaaagct ttctctggaa gaggaaaact gtcttattca gctgaagtgt gaaaaccttc     1860

aacaaaaatt agaacagatg gacgcagaaa ataaagagct tgagaagaag ctggcaaacc     1920

aagaagaatg tcttaagcac agcaatctta agtttaaaga gaaatctgca gagtatacag     1980

cattggccag acaactggaa gctgctttag aagaaggaag acaaaaggtt gctgaagaaa     2040

tagagaaaat gtcatctaga gagagtgctt tacaaattaa aatattagat ctggaaactg     2100

agcttagaaa gaaaaatgaa gaacaaaatc aacttgtttg caaaatgaac agtaaagcac     2160

aacatcagga agtgtgtttg aaagaagtac aaaatagtct tgagaagtcg gaaaatcaaa     2220

atgagagtat taagaattat ttacagtttc ttaaaacttc ttatgtaaca atgtttgaat     2280

aaattgtcaa attt                                                       2294


<210> 1743
<211> 4363
<212> DNA
<213> Homo sapiens

<400> 1743
ggtcccgact ccgatgatgg cggacggcgc cgcagctggc gctggcggca gcccatcctt       60

gagagagctg cgggcacgga tggttgctgc agcaaacgag attgctaagg aaaggaggaa      120

gcaagatgtg gttaatcgtg ttgcaaccca ttcctcaaat ataagatcga catttaaacc      180

agtaatcgat ggatccatgc ttaaaaatga cataaaacaa agattagcaa gagagcgcag      240

agaggagaaa aggagacagc aagacgccaa taaagaaaca caactacttg aaaaagaaag      300

aaagaccaag ctccaatatg aaaaacagat ggaggaaaga cagagaaagc tgaaggagcg      360

aaaagagaaa gaagaacaac ggagaatagc tgcagaagaa aaaagacacc agaaggatga      420

agcacaaaag gaaaaattta cagccattct ttatcgtact ttggaacgga ggagacttgc      480

tgatgattat cagcaaaaaa gatggtcatg gggaggctct gcaatggcga attctgagag      540

caaaactggg aaaacagaca aggagagaag ctcatcttta aatagaagag atagtaacct      600

acattcgtct actgataaag aacaagccga aaggaagcca cgtgttacag gcgtcaccaa      660

ttatgtaatg cagtatgtca ctgtaccctt gcgtaaatgt actagcgacg aattgagggc      720

tgttatgttt cccatgtcga caatgaaaat acctcctcaa acaaaagtag aagagtctcc      780

cttggagaaa gtagagacac ctcccaaggc aagtgtggat gcaccccccc aggtgaatgt      840

ggaagtattc tgcaacacaa gcatggaagc gtcccccaag gcaggtgtgg gcatggcccc      900

tgaggtgagc acggactcat tccctgtggt gagcgtggac gtgtcgcctg tggtgagcac      960

atatgattct gagatgagca tggacgcatc ccccgagttg agcatagaag cactcccgaa     1020

ggtggacctg gaaacagttc ccaaggtgag catagtagca tccccggagg cgagcctgga     1080

agcacccccg gaagtgagtc tggaagcact gccagaggtg agcgtggaag cagccccaga     1140

ggggagcctg gaagcacctc ccaaggggag cgcagaagta gcccccaagg agagtgtgaa     1200

agggtcaccc aaggagagca tggaggcatc tcctgaggcg atggtgaaag catcccccaa     1260

gacatccctt gaagcaagca tggaagcatc tcccaaggca aaagcgagag acgctccaaa     1320

gaaatcagaa atggacaaac aggccttaat ccctattgcc aagaagcgtc tatcatcata     1380

cactgagtgt tataaatggt catcatctcc tgaaaatgct tgtggtctgc cgtctcccat     1440

cagcactaac aggcaaatcc aaaagaactg ccctccatca ccattaccac ttatttcaaa     1500

acagtcacca cagacttctt ttccttataa aataatgcct attcaacaca ccctgtctgt     1560

gcaaagtgca tcaagtactg tcaaaaagaa aaaagaaaca gtttctaaaa ccactaacag     1620

atgtgaggct ttgagccaaa ggcatatgat ctatgaagag tctggtaata agagtactgc     1680

aggtattatg aatgccgagg cggcaacaaa aattttgaca gaattgcgcc gccttgctcg     1740

tgaacaaaga gaaaaagagg aagaagaaag acaacgggaa gaaatgcagc aaagggtcat     1800

taagaaatca aaagacatgg caaaggaagc agttggaggc caagcagaag accacttgaa     1860

actcaaagat gggcagcaac aaaatgagac taaaaagaag aaaggatggc tggatcagga     1920

agaccaggaa gcaccactgc agaaagggga cgccaaaata aaagctcaag aggaagctga     1980

caaacgcaag aaagaacacg agagaattat gttacaaaat ttacaagaac ggttagaaag     2040

gaaaaagaga atagaagaaa ttatgaagcg gacaagaaag acagatgtga atgcctcaaa     2100

ggtcacagaa acatccagcc atgacatata tgaagaggct gaggctgaca acgaagaaag     2160

cgacaaggac tcattgaatg aaatgtttcc atcagccatt ctaaatggca caggctcacc     2220

taccaaattt aaaatgccgt tcaacaatgc caagaaaatg acacacaagc tggtatttct     2280

agaagatggt accagccagg tccgtaaaga gccaaaaaca tattttaatg gcgatttgaa     2340

aaacttcaga caaaaaagca tgaaagacac ttcaatacag gaagtagttt caagaccatc     2400

ttccaaaaga atgaccagtc acacaacgaa aaccagaaag gcggatgaaa ccaacaccac     2460

cagcagatcc tctgcacaaa caaaatctga aggattccat gacatcttgc caaagtcctc     2520

agacaccttt agacaataag agaagaagca aacctgtttc tcctcatttg gaaatcccat     2580

tcctccttgt gtctcatctg agctggaaac tcttcactgc caagtctggc gccaggtcct     2640

gttgatccat ccattgaaac tgtctaccag gatgttcctg tttacaaggc caaggtgatg     2700

gacactgacc tagctttccc ctcacgcatt gctgcctcgc atttcccttc ctggtatcct     2760

ctacccggag ggacagaccc ctggcctcta ccagcagatt ctgcagatca gcgcattttc     2820

tacgcctgtg tcattgtgga cactgcatgt ggaatgaagt tttttaacag ctccaatccc     2880

taaaaaccac aagaatgcag tgtgaaatac cataaagaat gccagacagg cccctgaaga     2940

cctgaaccca gctgagaggg ctgctagctc acgtgtgaca ttgtgcacgt tgttgctctt     3000

ctctgatccc tgttccttgt ctgtcaaatg agggggctgt gctacaatct ctgcagcctt     3060

ttcagttttg agactccact gttctcaaac acctctaact ccttggagcc agagcaagag     3120

ggatcaggag gcataaaaca gcagcgatgg ccaaggagcc agagcgtgga ggcggactgt     3180

gcatgacatt ttatcatgtc agggggcaat tccctgtcat tttcagtgac cccacccctc     3240

cagtgcctgg ccggcctggt tggtcaaaac aggccccgaa acagcctcct tgcctttggt     3300

ctccttacca gtccagttac agtgtttcca gatgggtcct aggcacccat ctgattctaa     3360

tttccccaac tgtattgtaa tcattgcagt taggtttaca tgtgcaatat gcaaggtact     3420

tgataggcat tttctttttg tttttttgag atggagtctc gctctgttgc ccaggctgga     3480

atgcagtggc gtgatcttga ctcactgcaa cctctgcctc ccaggtttaa ggggttcatc     3540

tgcctcagcc tcctgagtag ctgggactac aggcacacac cacaacactt ggctaatttg     3600

tgtattttta gtagagacag ggtttcacca tgttggccag gctggtctcg aactcctgac     3660

ctcaggtgat ctgcctgcct cagcctccca aagtgctggg attacaggca tgagccaccg     3720

tgcccagcca ggcattttca atgctcacaa caactctatg aggtgtgggt attcatttat     3780

gcctatgagg acactgaaat ttgtggagag cagcatttgt tccaggtcac acagctggaa     3840

agagacagag ctgatattca aacccaagtt tgtccctcaa actaacaccc cacactgctt     3900

tgggagtgga catagtgtct tgaggcttgc agggtatgtc acagacacca gagcagtgtc     3960

tttggtgctg ggaatgaaat gtttgttggc atttagtgtg tttactgggt gccagtcccc     4020

tcactaagca cctgcattat gtctcccaca tgggattctg caaagtagaa attttacgtc     4080

tcacaggtga aggatcaagc tcagagaggt taacttgccc acagtctcat gactacaaag     4140

tggcagagca gccaggattt gaaccctggt agcctggtgc cagagcccac cctgttaacc     4200

acaagcagag aggttcttga tattctgatc ccattaatta tgagggagaa aatgtttctc     4260

tgctgacaaa ttgttaaggg gaaatttacc ctcatttctc ctgagcctta ggggtgtcac     4320

tcttaaaatc gcatattcaa caaacaaatg ccttctaagt act                       4363


<210> 1744
<211> 4446
<212> DNA
<213> Homo sapiens

<400> 1744
aaaaggaaat ggtacagagc agcctgttga aattagacag cagggtcacc ctggtcctct       60

gtgccacagg aaggaggggt actgaagtgt cagttgttgg tgggggagca gtgctgcagt      120

gggaattcca gagctgagaa ggctgccatc aaccaagtga gacatgacca gcccccgagt      180

tgctgcagca aacgagattg ctaaggaaag gaggaagcaa gatgtggtta atcgtgttgc      240

aacccattcc tcaaatataa gatcgacatt taaaccagta atcgatggat ccatgcttaa      300

aaatgacata aaacaaagat tagcaagaga gcgcagagag gagaaaagga gacagcaaga      360

cgccaataaa gaaacacaac tacttgaaaa agaaagaaag accaagctcc aatatgaaaa      420

acagatggag gaaagacaga gaaagctgaa ggagcgaaaa gagaaagaag aacaacggag      480

aatagctgca gaagaaaaaa gacaccagaa ggatgaagca caaaaggaaa aatttacagc      540

cattctttat cgtactttgg aacggaggag acttgctgat gattatcagc aaaaaagatg      600

gtcatgggga ggctctgcaa tggcgaattc tgagagcaaa actgccaata aacgatctgc      660

atctactgaa aaacttgaac agggtacttc tgctttaatc agacaaatgc ctttgtcatc      720

tgcaggcctt caaaattccg ttgccaaaag gaaaacagac aaggagagaa gctcatcttt      780

aaatagaaga gatagtaacc tacattcgtc tactgataaa gaacaagccg aaaggaagcc      840

acgtgttaca ggcgtcacca attatgtaat gcagtatgtc actgtaccct tgcgtaaatg      900

tactagcgac gaattgaggg ctgttatgtt tcccatgtcg acaatgaaaa tacctcctca      960

aacaaaagta gaagagtctc ccttggagaa agtagagaca cctcccaagg caagtgtgga     1020

tgcacccccc caggtgaatg tggaagtatt ctgcaacaca agcatggaag cgtcccccaa     1080

ggcaggtgtg ggcatggccc ctgaggtgag cacggactca ttccctgtgg tgagcgtgga     1140

cgtgtcgcct gtggtgagca catatgattc tgagatgagc atggacgcat cccccgagtt     1200

gagcatagaa gcactcccga aggtggacct ggaaacagtt cccaaggtga gcatagtagc     1260

atccccggag gcgagcctgg aagcaccccc ggaagtgagt ctggaagcac tgccagaggt     1320

gagcgtggaa gcagccccag aggggagcct ggaagcacct cccaagggga gcgcagaagt     1380

agcccccaag gagagtgtga aagggtcacc caaggagagc atggaggcat ctcctgaggc     1440

gatggtgaaa gcatccccca agacatccct tgaagcaagc atggaagcat ctcccaaggc     1500

aaaagcgaga gacgctccaa agaaatcaga aatggacaaa caggccttaa tccctattgc     1560

caagaagcgt ctatcatcat acactgagtg ttataaatgg tcatcatctc ctgaaaatgc     1620

ttgtggtctg ccgtctccca tcagcactaa caggcaaatc caaaagaact gccctccatc     1680

accattacca cttatttcaa aacagtcacc acagacttct tttccttata aaataatgcc     1740

tattcaacac accctgtctg tgcaaagtgc atcaagtact gtcaaaaaga aaaaagaaac     1800

agtttctaaa accactaaca gatgtgaggc tttgagccaa aggcatatga tctatgaaga     1860

gtctggtaat aagagtactg caggtattat gaatgccgag gcggcaacaa aaattttgac     1920

agaattgcgc cgccttgctc gtgaacaaag agaaaaagag gaagaagaaa gacaacggga     1980

agaaatgcag caaagggtca ttaagaaatc aaaagacatg gcaaaggaag cagttggagg     2040

ccaagcagaa gaccacttga aactcaaaga tgggcagcaa caaaatgaga ctaaaaagaa     2100

gaaaggatgg ctggatcagg aagaccagga agcaccactg cagaaagggg acgccaaaat     2160

aaaagctcaa gaggaagctg acaaacgcaa gaaagaacac gagagaatta tgttacaaaa     2220

tttacaagaa cggttagaaa ggaaaaagag aatagaagaa attatgaagc ggacaagaaa     2280

gacagatgtg aatgcctcaa aggtcacaga aacatccagc catgacatat atgaagaggc     2340

tgaggctgac aacgaagaaa gcgacaagga ctcattgaat gaaatgtttc catcagccat     2400

tctaaatggc acaggctcac ctaccaaatt taaaatgccg ttcaacaatg ccaagaaaat     2460

gacacacaag ctggtatttc tagaagatgg taccagccag gtccgtaaag agccaaaaac     2520

atattttaat ggcgatttga aaaacttcag acaaaaaagc atgaaagaca cttcaataca     2580

ggaagtagtt tcaagaccat cttccaaaag aatgaccagt cacacaacga aaaccagaaa     2640

ggcggatgaa accaacacca ccagcagatc ctctgcacaa acaaaatctg aaggattcca     2700

tgacatcttg ccaaagtcct cagacacctt tagacaataa gagaagaagc aaacctgttt     2760

ctcctcattt ggatatgtaa accttactca gcctgggaga tgaatacatc ttccactctg     2820

gataactcaa ctcctgggcc catcagtcct caaatttttc tgcttctgac ttgaacctgg     2880

taaaggaagt gacaccgaaa aattgaaaga aactgtcaaa aggccacttt gatgtatatc     2940

tcagatgtta aagtcatctt attctcttgt gtctaagcaa gagttctaag taaagagtgg     3000

tttttgtttt ctttggaaaa tcatcattgt ctctcattct tgtgttgtcc caccaatgtg     3060

tttgctggag tgagtgcatc aaggatgctt tcctgaaact gtaactgtgg agtttctaga     3120

agaatctgat tgcagaacta attctctttc agtatatatt tgaaatctta aagtaatgct     3180

ttttcttttt ctttttcttt tttttttttt tgagacggag tcttgccctg tcgcccaggc     3240

tgcagtgcag tggcacaatc tcggctcact gcaacctccg cctcctcatc tcaagcaatt     3300

ctcctgtctc agcctcccca gtagctggga ttacaggcat gtgccaccac acctggctaa     3360

tttttttgta ttttagtaga gatagggttt taccatgttc accaggctag tctcgaaatc     3420

ctggcctcaa gagatccacc cgtcttggcc tcccaaagtg ttgggattac aggtgtgagc     3480

cactgcaccc agccaagtaa tgctttttct gtgtaccagt gacaattttg acagctaaaa     3540

actcacagtt gatcttgtag agaacagaat agattatgca agggccgcag gatcgctcac     3600

aagagctgtc agattgtttc taatataaaa ataccaaagg ttgcaaaatc cagcaaattg     3660

tattttactg tgatatatgt atatttttaa ctctacccat ctgtgccagt gagtacacag     3720

gcactaataa cctgaaatgc tgggagtcct gtaaagcccc atcttggaac agtcagcacc     3780

tttcatgctc ttgtcagtgt ttccttttga aggacatatt ggtgtttatc tacagaaaca     3840

tatattattt ttattgtgta cataaaggag tatatggctg ttgtcccgtg gggtatgttt     3900

aattcctcta aatgtttaaa gtacttttct gcctgtactc tccagttctg tcgttgagta     3960

tacactcagg cttgagatac aaccaaaatt tgcttgcctt tctctagcca ctggctgcca     4020

gtgagttcgt gtgatgggca cacagaaatg cacacagatg tacatacacg tatgtatgca     4080

cacacagtat atgattccat aaaattcaaa tgcagattaa ttctcctaat gagttttcag     4140

tgttgaatcg taaatagtct gaagcaggcc agtgttcctt ttggctgcca gtcttggatt     4200

agtaaaagga ggtaattctt tcagattccc tggttctttg ccactcagag tattgtactt     4260

ttgatataga atagagaagg ttacctttgg tttaaaaact atttttatat actagctctt     4320

tcatgtataa aacagagaca atcatcctaa caaaagagtt cctgttattt ttctgcacaa     4380

atgtcttgtg ttgaaacact gttacagttc catataaatg tgtgctatat aaaataaact     4440

ttggag                                                                4446


<210> 1745
<211> 3847
<212> DNA
<213> Homo sapiens

<400> 1745
gctgggcggg cgggcggctg ctccggtcca ggggtggagg tcggggccct gacccgacgc       60

agccaggcgg aagcgcggct gccattggag gctgctttta cctgcgcggg gcccggggcg      120

caaagtccga ggcgccgggg ggaggaggcg gcggacggca gcgcaggtgg gcccgcgctc      180

tcggccctgc aagatgcccc tgaagctgcg ggggaagaag aaggccaagt ccaaggagac      240

cgccgggctg gtggagggcg agccgacggg cgcgggcggc gggagcctct cagcgtcccg      300

ggctcccgca cgcaggctgg tcttccacgc gcagctggcg cacggtagtg ccacgggccg      360

agtggagggc ttctccagca tccaggagct ctacgcccag atcgcgggcg cgtttgaaat      420

ctcgccgtcg gagatcttat attgcacttt aaacacacct aaaattgaca tggaaagact      480

cttaggagga caactaggac tagaagattt catatttgcc catgtgaaag gaatcgaaaa      540

agaagtgaat gtgtataaat ctgaggattc acttggtctc accattacag ataatggtgt      600

tggctatgct tttataaaga gaattaaaga tggtggtgtt attgactcag ttaaaacaat      660

ctgtgttggg gatcatattg aatccataaa tggagaaaat attgttgggt ggcgtcacta      720

tgatgttgct aagaagttaa aggaattaaa aaaggaggaa ctctttacta tgaagttaat      780

agaacctaag aaggcatttg aaatagagct gaggtcaaag gctggaaagt catcaggaga      840

aaaaattggt tgtggaaggg caacacttcg cctgagatca aaaggtcctg ccaccgtgga      900

agaaatgcct tctgaaacca aagcaaaggc aattgaaaag attgatgatg ttcttgagtt      960

gtacatggga attcgagata ttgatttagc caccacaatg tttgaagctg gaaaggacaa     1020

agtaaatcca gatgaatttg ctgtggcact tgacgaaact cttggagact ttgcgttccc     1080

agacgaattt gtctttgatg tttggggagt cattggtgat gccaaacgaa gaggattatg     1140

atgtgtacac tccatctctg aagaaacaac ccatcgttct tttttttctc ttttttaaaa     1200

agtcctataa gatctgtttt tggacacctt tactaactct ggtttaattt catgtgtatg     1260

gaatatattc tttgaaatat aattttggta attttgattt ctgggcactt tttaacattg     1320

ctgatgtagt atgcttaaga gaaatgacct aaataaggat caattgtaat attcattcaa     1380

aaggttttta aaagtaagtt ttaaggagta tttctcgaca gatgattttc ttctccatta     1440

atacccatgc tttgtttttc acatataaat agatgatttc aatagctttg tagttttttt     1500

tcaaaatctt aatgtaaact aggattggag tatgatttac ctcatagtat cttcactgtg     1560

ttatcctagt ttgaacagga tatgttcagg aaatgaaagg tgaattatgc cccttattgg     1620

tctagaagca ttggtttttt tttgatcctc tgagtaaggg aaggaagatt cctgtggcat     1680

gttgatttct atggccaact ttctctcttt gtaaaacaaa gattgattga ttttcttgta     1740

tgcttcttta tacatgctct taaaacttgt ggttgaaatc tgtgctgtgt gtgtgtgtct     1800

ctgcatgtgt aaaagaaggg taaaaaagag atgggtaggg tagaactact tgcatttgat     1860

ttttttttca gtccttaaaa cattatttct ttttttcact catagccact tttatgttac     1920

cttttataag cactccaggg aagattttat atttttttgt agagtttttg gaaagatatt     1980

tactcaaaat aactatgctt tagaactttt tttttttttt tttttttggt taaacagcag     2040

cactttttag ttccctaaac tttagaagaa atgctatcag aaatagattt ccttccagtg     2100

gaaagaaagg aggaagggag aattgagaaa atatattagt ctattatttt agagttctaa     2160

tacactctaa attaaagaga aaattgagag taaatgactg tcttatcact cttatttgac     2220

atttcgtagg tgtaagagaa atggaaatga atggtttcaa caaagatcat ttaatacagc     2280

agagcatggc atgaccaagc atctttgtaa agtgttagat ggaaaatgct gtgtgctgcc     2340

atggtaatca gaaataataa cctgttaggg atgtattcta ggaaatcaga agtagttctc     2400

ttttcttgct ggattattgc ttagataact cttgttttct ggtaaaactt tagttgtatt     2460

gccatccact cctttttcaa atgagtttaa tgccataaag ctgatattct ttgtccgatt     2520

aatttgaaat ctgcacagaa gctgttttag tcattaatgt gtaacaaaag tagcttatag     2580

aatatggact gccttattgc tgttgcttat catttgaaaa taaaatccag ctcaggttgt     2640

aacttgttgg tactcgttta gtgagttcgt tttggaggtt ctgaaatacc tattaattct     2700

taatattacc tctcttggaa agacacaaaa aaagagctgt tatttttagg cataagatga     2760

cttaggaggc ccatagaaac attctcgttt aaacaacaac aacaaaataa atttatcagc     2820

actagatatt agatttgaaa taagtcattg ttcattattg atggttgtca gtttctcctt     2880

cctttttggg catgcataaa gacacacttg gtgctgattc catgtgattt atggaatgtc     2940

attttcacaa tgatctttct agaatttgtg tgtaaggttg tgatatccat gtacagctgt     3000

aactatatat acttgtctgt tagcattcag tggaccatta tcattactat catcacatta     3060

cctgggcttc aactgggccc aagtactcta tatactgcct gtaataggtt tttccttgaa     3120

atatccttat ctttcacctc tacagctaaa ctgataacaa ggtcagtttc tttatgtcat     3180

tttattccca tacctaaaat tgcatctatt tgtgagcttt ctgccttttt gtaacgctca     3240

gtgcaccaaa agcgtctgtt tttagtgcag tcacataata tataagtgtg ggataccctt     3300

ctgcagcttc agtgagacaa atcacttttt aaaaaacatt ccattttatt ggcatcacta     3360

gatgttttta ggaccctgtc cttttcactt ttctgtaggc tttttttttt taaatggaag     3420

atgattattt tgtttgttct tgatttcctg ttattgaaaa cagcatcttc cttcttgcaa     3480

tggccactaa tagcacacaa tgcgttttct ttgattgtag cagaaaatgc aaatgataat     3540

tgtatgttgg gctcgatgag gccttgaaca tagctgagtc ctaatcagat gtatatactc     3600

tgatgattac aaataggtac atgttgggtt tctgtgatgt ttcaaaaata caattatata     3660

attatgatgt aaactcttta agaattcaat tataaaagca ataatcaggt aacctctatt     3720

tggagctgct acatccaata ttgtgactga aaattaacta aagagagata atttttcaaa     3780

tgatgtataa tttgcaatat tttcccttgc aactttagca aatacacata ttccaagtaa     3840

aacttta                                                               3847


<210> 1746
<211> 2917
<212> DNA
<213> Homo sapiens

<400> 1746
ggagacaccg gaaggagccg cggctgctgc gggaagtggc cagttcagga ggcggacccc       60

ccgagggcag cgctgcgggg ccgttttccg gccctcctga cgcgacactg cccctctccg      120

agagctgaga aggaaaagag gagcttgcgg aggtgcggct gcaggccgtt gttggtcgag      180

ctggcgggtc ccgcgggcca ggccgtggag agctcctgaa ggaagcacta aacatggaaa      240

ggaacaaccg gtaccagcca ctgcaaaaac atgccaaatt gtaaagacca tcgatgttag      300

gaagaaactg cctcaactaa tgagcaaaat aaccagctaa catcgtaatg acaggatcaa      360

attcacacat aacgatatta accttaaagg tgttacctca ttttgaaagt cttgggaaac      420

aggaaaaaat tcctaacaaa atgtcagctt ttcgaaatca ttgtccacat ttggattcag      480

ttggtgaaat aacaaaagaa gatttgatac aaaaatccct tggtacttgt caggattgta      540

aagtccaagg accaaatctt tgggcatgtc tggagaatag atgttcatat gttggctgtg      600

gtgaatcaca agtagatcac agcaccatac attctcagga gacaaagcat tatctaactg      660

tgaaccttac cactcttcga gtatggtgtt atgcttgcag caaagaagta tttttggata      720

ggaaattagg aactcagcct tcattgcctc atgtaagaca acctcaccaa atacaagaaa      780

acagtgtcca ggattttaaa atacccagta atacaacatt aaaaactcct ctggttgccg      840

tatttgatga tctggatata gaagcggatg aagaagatga acttagggcc agaggtctta      900

caggtttgaa aaatattgga aatacttgtt acatgaatgc agctttgcag gctctttcta      960

attgcccacc tttgacacag ttttttcttg attgtggagg actagctcga acagataaga     1020

aacctgccat ttgtaaaagt tatctcaaac taatgacaga gctgtggcat aaaagcaggc     1080

caggatctgt tgtgcctact actctgtttc aaggaattaa aactgtaaat ccaacatttc     1140

gggggtattc tcagcaggat gctcaagaat tccttcgatg tttaatggat ttgcttcatg     1200

aagaattgaa agagcaagtc atggaagtag aagaagatcc gcaaaccata accactgagg     1260

agacaatgga agaagacaag agccagtcgg atgtagattt tcagtcttgt gaatcttgta     1320

gcaacagtga tagagcagaa aatgaaaatg gctctagatg cttttctgaa gataataatg     1380

aaacaacaat gttaattcag gatgatgaaa acaattcaga aatgtcaaag gattggcaaa     1440

aagagaagat gtgcaataag attaataaag taaattctga aggcgaattt gataaagata     1500

gagactctat atctgaaaca gtcgacttaa acaaccagga aactgtcaaa gtgcaaatac     1560

acagcagagc ttcagaatat atcactgatg tccattcgaa tgacctgtct acaccacaga     1620

tccttccatc aaatgaaggt gttaatccac gtttatcggc aagccctcct aaatcaggca     1680

atttgtggcc aggattggca ccaccacaca aaaaagctca gtctgcatct ccaaagagaa     1740

aaaaacagca caagaaatac agaagtgtta tttcagacat atttgatgga acaatcatta     1800

gttcagtgca gtgtctgact tgtgacaggg tgtctgtaac cctcgagacc tttcaagatc     1860

tgtccttgcc aattcctggc aaggaagacc ttgctaagct gcattcatca agtcatccaa     1920

cttctatagt caaagcagga tcatgtggcg aagcatatgc tccacaaggg tggatagctt     1980

ttttcatgga atatgtgaag agctggtttt ggggtccagt agtaaccttg caagattgtc     2040

ttgctgcctt ctttgccaga gatgaactaa aaggtgacaa tatgtacagt tgtgaaaaat     2100

gcaaaaagtt gagaaatgga gtgaagtttt gtaaagtaca aaactttcct gagattttgt     2160

gcatccacct taaaagattc agacatgaac taatgttttc caccaaaatc agtacccatg     2220

tttcatttcc gctagaaggc ttggatcttc agccatttct tgctaaggat agtccagctc     2280

aaattgtgac atatgatctt ctgtcagtca tttgccatca tggaactgca agtagtggac     2340

actatatagc ctactgccga aacaatctaa ataatctctg gtatgaattt gatgatcaga     2400

gtgtcactga agtttcagaa tctactgtac aaaatgcaga agcttacgtt cttttctata     2460

ggaagagcag cgaagaggca caaaaagaga ggagaaggat atcaaattta ttgaacataa     2520

tggaaccaag cctccttcag ttttatattt ctcgacagtg gcttaataaa tttaagacct     2580

ttgccgaacc tggccctatt tcaaataatg actttctttg tattcatgga ggtgttcctc     2640

caagaaaagc tggttatatt gaagacctgg ttttgatgct gcctcagaac atttgggata     2700

acctatatag caggtatggt ggaggaccag ctgtcaacca tctgtacatt tgtcatactt     2760

gccaaattga ggcggagaaa attgaaaaaa gaagaaaaac tgaattggaa atttttattc     2820

gggtaaaaaa gtgatgcttt tcaaattgat ctaggataaa gatgaagacc tgacaattat     2880

cagagttata tgatattaat aaaatgatta gatgaaa                              2917


<210> 1747
<211> 4502
<212> DNA
<213> Homo sapiens

<400> 1747
ggagacaccg gaaggagccg cggctgctgc gggaagtggc cagttcagga ggcggacccc       60

ccgagggcag cgctgcgggg ccgttttccg gccctcctga cgcgacactg cccctctccg      120

agagctgaga aggaaaagag gagcttgcgg aggtgcggct gcaggccgtt gttggtcgag      180

ctggcgggtc ccgcgggcca ggccgtggag agctcctgaa ggaagcacta aacatggaaa      240

ggaacaaccg gtaccagcca ctgcaaaaac atgccaaatt gtaaagacca tcgatgttag      300

gaagaaactg cctcaactaa tgagcaaaat aaccagctaa catcgtaatg acaggatcaa      360

attcacacat aacgatatta accttaaagg tgttacctca ttttgaaagt cttgggaaac      420

aggaaaaaat tcctaacaaa atgtcagctt ttcgaaatca ttgtccacat ttggattcag      480

ttggtgaaat aacaaaagaa gatttgatac aaaaatccct tggtacttgt caggattgta      540

aagtccaagg accaaatctt tgggcatgtc tggagaatag atgttcatat gttggctgtg      600

gtgaatcaca agtagatcac agcaccatac attctcagga gacaaagcat tatctaactg      660

tgaaccttac cactcttcga gtatggtgtt atgcttgcag caaagaagta tttttggata      720

ggaaattagg aactcagcct tcattgcctc atgtaagaca acctcaccaa atacaagaaa      780

acagtgtcca ggattttaaa atacccagta atacaacatt aaaaactcct ctggttgccg      840

tatttgatga tctggatata gaagcggatg aagaagatga acttagggcc agaggtctta      900

caggtttgaa aaatattgga aatacttgtt acatgaatgc agctttgcag gctctttcta      960

attgcccacc tttgacacag ttttttcttg attgtggagg actagctcga acagataaga     1020

aacctgccat ttgtaaaagt tatctcaaac taatgacaga gctgtggcat aaaagcaggc     1080

caggatctgt tgtgcctact actctgtttc aaggaattaa aactgtaaat ccaacatttc     1140

gggggtattc tcagcaggat gctcaagaat tccttcgatg tttaatggat ttgcttcatg     1200

aagaattgaa agagcaagtc atggaagtag aagaagatcc gcaaaccata accactgagg     1260

agacaatgga agaagacaag agccagtcgg atgtagattt tcagtcttgt gaatcttgta     1320

gcaacagtga tagagcagaa aatgaaaatg gctctagatg cttttctgaa gataataatg     1380

aaacaacaat gttaattcag gatgatgaaa acaattcaga aatgtcaaag gattggcaaa     1440

aagagaagat gtgcaataag attaataaag taaattctga aggcgaattt gataaagata     1500

gagactctat atctgaaaca gtcgacttaa acaaccagga aactgtcaaa gtgcaaatac     1560

acagcagagc ttcagaatat atcactgatg tccattcgaa tgacctgtct acaccacaga     1620

tccttccatc aaatgaaggt gttaatccac gtttatcggc aagccctcct aaatcaggca     1680

atttgtggcc aggattggca ccaccacaca aaaaagctca gtctgcatct ccaaagagaa     1740

aaaaacagca caagaaatac agaagtgtta tttcagacat atttgatgga acaatcatta     1800

gttcagtgca gtgtctgact tgtgacaggg tgtctgtaac cctcgagacc tttcaagatc     1860

tgtccttgcc aattcctggc aaggaagacc ttgctaagct gcattcatca agtcatccaa     1920

cttctatagt caaagcagga tcatgtggcg aagcatatgc tccacaaggg tggatagctt     1980

ttttcatgga atatgtgaag aggtttgttg tctcatgtgt ccctagctgg ttttggggtc     2040

cagtagtaac cttgcaagat tgtcttgctg ccttctttgc cagagatgaa ctaaaaggtg     2100

acaatatgta cagttgtgaa aaatgcaaaa agttgagaaa tggagtgaag ttttgtaaag     2160

tacaaaactt tcctgagatt ttgtgcatcc accttaaaag attcagacat gaactaatgt     2220

tttccaccaa aatcagtacc catgtttcat ttccgctaga aggcttggat cttcagccat     2280

ttcttgctaa ggatagtcca gctcaaattg tgacatatga tcttctgtca gtcatttgcc     2340

atcatggaac tgcaagtagt ggacactata tagcctactg ccgaaacaat ctaaataatc     2400

tctggtatga atttgatgat cagagtgtca ctgaagtttc agaatctact gtacaaaatg     2460

cagaagctta cgttcttttc tataggaaga gcagcgaaga ggcacaaaaa gagaggagaa     2520

ggatatcaaa tttattgaac ataatggaac caagcctcct tcagttttat atttctcgac     2580

agtggcttaa taaatttaag acctttgccg aacctggccc tatttcaaat aatgactttc     2640

tttgtattca tggaggtgtt cctccaagaa aagctggtta tattgaagac ctggttttga     2700

tgctgcctca gaacatttgg gataacctat atagcaggta tggtggagga ccagctgtca     2760

accatctgta catttgtcat acttgccaaa ttgaggcgga gaaaattgaa aaaagaagaa     2820

aaactgaatt ggaaattttt attcggctta acagagcgtt ccaaaaagag gactctccag     2880

ctacttttta ttgcatcagt atgcagtggt ttagagaatg ggaaagtttt gtgaagggta     2940

aagatggaga tcctccaggt cctattgaca atactaagat tgcagtcact aaatgtggta     3000

atgtgatgct taggcaagga gcagattctg gccagatttc tgaagaaaca tggaattttc     3060

tgcagtctat ttatggtgga gggcctgaag ttatcctgcg acctccggtt gttcatgttg     3120

atccagatat acttcaagca gaagaaaaaa ttgaagtaga aactcggtct ttgtaatttt     3180

taggatgtag agagttctaa tgaggaatca ttttcatgtg ccctgacatg tacacatgcg     3240

aaaacattcc taaaagcgtg tttatttgct ttattttttt tcatcattta tcccatttat     3300

ttcttcttag tgggcattat ggaagaatat attaaaatgt gtaatatacc acaggttggt     3360

atatttagtt ttaaatactt accataaagt ctttcagtgt aatttttttt tgagacagag     3420

tcttgctttg tcacccaggc tggagtgctg tggtgttacc tcagctcact gcagcctcca     3480

cctcctgggt tcaagcgatt ctcctgcctc agcctctcga gtagctggga ttacaggcac     3540

ctgccaccat gcccggctaa tttttgtatt ttagtagaga tggggtttca ccatgttggc     3600

caggctagtc tcaaactcct gacctcaggt gatccaccca cctcggcctc ccaaagtgct     3660

gggattacag gtgtgagcca cagcgcctgg cccagtgtaa tatttttgaa agaggaggga     3720

caattgtgaa atcagtaggt tatctttaat ctttacacta catgcagatc catagtatcc     3780

tttgtagtgt tgtaaatact tttgctttga aaactttttc attgtcctaa atcaccctga     3840

ctctgaccag tctttcagtt ctccaaaagc ccaatttaat tgtatagttt tgtcatggct     3900

tcatataata aagagcctat tttaagttga aagtagtagt cagaaaattg ttaatttcct     3960

aaagctcagg aaactagggt gtcacttttt ttgcactgca gcatatacac taactagctt     4020

attaaaattt acaaaatgtc tttttgaatg tatcaaggat atatttagtt tgagtggaat     4080

ttgtcagcag atatcagtaa cttattgccg cttatattgt acaatgttaa acttcaattc     4140

ctgtaacctg gttagtatta atgtcagtga ctaaaaaact tagagttagt tttagggcac     4200

tttttatttt gagagcatga agtgtggaat gtgtcactac gattgttgat aaagctgagg     4260

ccacttgcaa cttgattttt taaatgaaat agataaagtc tttttgaata atatagtatg     4320

cactgctatt tgcttgatta tgtaatgtca aaagtttaac tatattccaa gtacaaaaac     4380

atactggatt acattgagga tgttgaatag cattcatgat ggctttgttt tggtttgggg     4440

cagctgtcac cagctaaagc aatgttgtta aaattagctc aataaaaatg tctttaaaat     4500

gt                                                                    4502


<210> 1748
<211> 4327
<212> DNA
<213> Homo sapiens

<400> 1748
ggagacaccg gaaggagccg cggctgctgc gggaagtggc cagttcagga ggcggacccc       60

ccgagggcag cgctgcgggg ccgttttccg gccctcctga cgcgacactg cccctctccg      120

agagctgaga aggaaaagag gagcttgcgg aggtgcggct gcaggccgtt gttggtcgag      180

ctggcgggtc ccgcgggcca ggccgtggag gtgttacctc attttgaaag tcttgggaaa      240

caggaaaaaa ttcctaacaa aatgtcagct tttcgaaatc attgtccaca tttggattca      300

gttggtgaaa taacaaaaga agatttgata caaaaatccc ttggtacttg tcaggattgt      360

aaagtccaag gaccaaatct ttgggcatgt ctggagaata gatgttcata tgttggctgt      420

ggtgaatcac aagtagatca cagcaccata cattctcagg agacaaagca ttatctaact      480

gtgaacctta ccactcttcg agtatggtgt tatgcttgca gcaaagaagt atttttggat      540

aggaaattag gaactcagcc ttcattgcct catgtaagac aacctcacca aatacaagaa      600

aacagtgtcc aggattttaa aatacccagt aatacaacat taaaaactcc tctggttgcc      660

gtatttgatg atctggatat agaagcggat gaagaagatg aacttagggc cagaggtctt      720

acaggtttga aaaatattgg aaatacttgt tacatgaatg cagctttgca ggctctttct      780

aattgcccac ctttgacaca gttttttctt gattgtggag gactagctcg aacagataag      840

aaacctgcca tttgtaaaag ttatctcaaa ctaatgacag agctgtggca taaaagcagg      900

ccaggatctg ttgtgcctac tactctgttt caaggaatta aaactgtaaa tccaacattt      960

cgggggtatt ctcagcagga tgctcaagaa ttccttcgat gtttaatgga tttgcttcat     1020

gaagaattga aagagcaagt catggaagta gaagaagatc cgcaaaccat aaccactgag     1080

gagacaatgg aagaagacaa gagccagtcg gatgtagatt ttcagtcttg tgaatcttgt     1140

agcaacagtg atagagcaga aaatgaaaat ggctctagat gcttttctga agataataat     1200

gaaacaacaa tgttaattca ggatgatgaa aacaattcag aaatgtcaaa ggattggcaa     1260

aaagagaaga tgtgcaataa gattaataaa gtaaattctg aaggcgaatt tgataaagat     1320

agagactcta tatctgaaac agtcgactta aacaaccagg aaactgtcaa agtgcaaata     1380

cacagcagag cttcagaata tatcactgat gtccattcga atgacctgtc tacaccacag     1440

atccttccat caaatgaagg tgttaatcca cgtttatcgg caagccctcc taaatcaggc     1500

aatttgtggc caggattggc accaccacac aaaaaagctc agtctgcatc tccaaagaga     1560

aaaaaacagc acaagaaata cagaagtgtt atttcagaca tatttgatgg aacaatcatt     1620

agttcagtgc agtgtctgac ttgtgacagg gtgtctgtaa ccctcgagac ctttcaagat     1680

ctgtccttgc caattcctgg caaggaagac cttgctaagc tgcattcatc aagtcatcca     1740

acttctatag tcaaagcagg atcatgtggc gaagcatatg ctccacaagg gtggatagct     1800

tttttcatgg aatatgtgaa gaggtttgtt gtctcatgtg tccctagctg gttttggggt     1860

ccagtagtaa ccttgcaaga ttgtcttgct gccttctttg ccagagatga actaaaaggt     1920

gacaatatgt acagttgtga aaaatgcaaa aagttgagaa atggagtgaa gttttgtaaa     1980

gtacaaaact ttcctgagat tttgtgcatc caccttaaaa gattcagaca tgaactaatg     2040

ttttccacca aaatcagtac ccatgtttca tttccgctag aaggcttgga tcttcagcca     2100

tttcttgcta aggatagtcc agctcaaatt gtgacatatg atcttctgtc agtcatttgc     2160

catcatggaa ctgcaagtag tggacactat atagcctact gccgaaacaa tctaaataat     2220

ctctggtatg aatttgatga tcagagtgtc actgaagttt cagaatctac tgtacaaaat     2280

gcagaagctt acgttctttt ctataggaag agcagcgaag aggcacaaaa agagaggaga     2340

aggatatcaa atttattgaa cataatggaa ccaagcctcc ttcagtttta tatttctcga     2400

cagtggctta ataaatttaa gacctttgcc gaacctggcc ctatttcaaa taatgacttt     2460

ctttgtattc atggaggtgt tcctccaaga aaagctggtt atattgaaga cctggttttg     2520

atgctgcctc agaacatttg ggataaccta tatagcaggt atggtggagg accagctgtc     2580

aaccatctgt acatttgtca tacttgccaa attgaggcgg agaaaattga aaaaagaaga     2640

aaaactgaat tggaaatttt tattcggctt aacagagcgt tccaaaaaga ggactctcca     2700

gctacttttt attgcatcag tatgcagtgg tttagagaat gggaaagttt tgtgaagggt     2760

aaagatggag atcctccagg tcctattgac aatactaaga ttgcagtcac taaatgtggt     2820

aatgtgatgc ttaggcaagg agcagattct ggccagattt ctgaagaaac atggaatttt     2880

ctgcagtcta tttatggtgg agggcctgaa gttatcctgc gacctccggt tgttcatgtt     2940

gatccagata tacttcaagc agaagaaaaa attgaagtag aaactcggtc tttgtaattt     3000

ttaggatgta gagagttcta atgaggaatc attttcatgt gccctgacat gtacacatgc     3060

gaaaacattc ctaaaagcgt gtttatttgc tttatttttt ttcatcattt atcccattta     3120

tttcttctta gtgggcatta tggaagaata tattaaaatg tgtaatatac cacaggttgg     3180

tatatttagt tttaaatact taccataaag tctttcagtg taattttttt ttgagacaga     3240

gtcttgcttt gtcacccagg ctggagtgct gtggtgttac ctcagctcac tgcagcctcc     3300

acctcctggg ttcaagcgat tctcctgcct cagcctctcg agtagctggg attacaggca     3360

cctgccacca tgcccggcta atttttgtat tttagtagag atggggtttc accatgttgg     3420

ccaggctagt ctcaaactcc tgacctcagg tgatccaccc acctcggcct cccaaagtgc     3480

tgggattaca ggtgtgagcc acagcgcctg gcccagtgta atatttttga aagaggaggg     3540

acaattgtga aatcagtagg ttatctttaa tctttacact acatgcagat ccatagtatc     3600

ctttgtagtg ttgtaaatac ttttgctttg aaaacttttt cattgtccta aatcaccctg     3660

actctgacca gtctttcagt tctccaaaag cccaatttaa ttgtatagtt ttgtcatggc     3720

ttcatataat aaagagccta ttttaagttg aaagtagtag tcagaaaatt gttaatttcc     3780

taaagctcag gaaactaggg tgtcactttt tttgcactgc agcatataca ctaactagct     3840

tattaaaatt tacaaaatgt ctttttgaat gtatcaagga tatatttagt ttgagtggaa     3900

tttgtcagca gatatcagta acttattgcc gcttatattg tacaatgtta aacttcaatt     3960

cctgtaacct ggttagtatt aatgtcagtg actaaaaaac ttagagttag ttttagggca     4020

ctttttattt tgagagcatg aagtgtggaa tgtgtcacta cgattgttga taaagctgag     4080

gccacttgca acttgatttt ttaaatgaaa tagataaagt ctttttgaat aatatagtat     4140

gcactgctat ttgcttgatt atgtaatgtc aaaagtttaa ctatattcca agtacaaaaa     4200

catactggat tacattgagg atgttgaata gcattcatga tggctttgtt ttggtttggg     4260

gcagctgtca ccagctaaag caatgttgtt aaaattagct caataaaaat gtctttaaaa     4320

tgtaaaa                                                               4327


<210> 1749
<211> 498
<212> DNA
<213> Homo sapiens

<400> 1749
gttttcatcc tggttttggg acagcggcaa tcatggcgcc acctgtgaga tactgcatcc       60

ccggcgaacg tctgtgtaac ttggaggagg gcagcccggg cagcggcacc tacacccgcc      120

acggctacat cttttcgtcg cttgccggct gtctgatgaa gagcagcgag aatggcgcgc      180

ttccagtggt gtctgtagtg agagaaacag agtcccagtt actgccagat gtgggagcta      240

ttgtaacctg taaggttgaa atttataaga gtttccgccc aggtgacatt gtcttggcca      300

aagtgatctc cttaggtgat gcacagtcca actacctgct aaccaccgcc gagaacgagc      360

tgggagtggt ggtagcccac agtgagtcag gtatccagat ggttcccatc agctggtgtg      420

agatgcagtg ccctaagacc cacactaaag aattccggaa agtagcccga gtacaacccg      480

aattcttgca gacctaag                                                    498


<210> 1750
<211> 718
<212> DNA
<213> Homo sapiens

<400> 1750
cggcaatcat ggcgccacct gtgagatact gcatccccgg cgaacgtctg tgtaacttgg       60

aggagggcag cccgggcagc ggcacctaca cccgccacgg ctacatcttt tcgtcgcttg      120

ccggctgtct gatgaagagc agcgagaatg gcgcggtctc tagcatcaat tcacgctttg      180

ccaaagtaca catcctgtat gtggggtcca tgcctcttaa gaactctttt cgaggaacta      240

tccgcaagga agatgtccga gcaactgaaa aagacaaggt tgaaatttat aagagtttcc      300

gcccaggtga cattgtcttg gccaaagtga tctccttagg tgatgcacag tccaactacc      360

tgctaaccac cgccgagaac gagctgggag tggtggtagc ccacagtgag tcaggtatcc      420

agatggttcc catcagctgg tgtgagatgc agtgccctaa gacccacact aaagaattcc      480

ggaaagtagc ccgagtacaa cccgaattct tgcagaccta agaagccact ttttacccta      540

tggaaggggg taagctgttc ctgagtataa caccaagatg ctgctgtctt tattcaaaca      600

cctggcgtcg gccaacagcc acttccagaa aaatcttcca gtttacgctg tagatggaac      660

atgtttctgt gaacctatca gtggatttca ttctcttgag taataaatct tatctttt        718


<210> 1751
<211> 739
<212> DNA
<213> Homo sapiens

<400> 1751
catggcgcca cctgtgagat actgcatccc cggcgaacgt ctgtgtaact tggaggaggg       60

cagcccgggc agcggcacct acacccgcca cggctacatc ttttcgtcgc ttgccggctg      120

tctgatgaag agcagcgaga atggcgcgct tccagtggtg tctgtagtga gagaaacaga      180

gtcccagtta ctgccagatg tgggagctat tgtaacctgt aaggtctcta gcatcaattc      240

acgctttgcc aaagtacaca tcctgtatgt ggggtccatg cctcttaaga actcttttcg      300

aggaactatc cgcaaggaag atgtccgagc aactgaaaaa gacaagatct ccttaggtga      360

tgcacagtcc aactacctgc taaccaccgc cgagaacgag ctgggagtgg tggtagccca      420

cagtgagtca ggtatccaga tggttcccat cagctggtgt gagatgcagt gccctaagac      480

ccacactaaa gaattccgga aagtagcccg agtacaaccc gaattcttgc agacctaaga      540

agccactttt taccctatgg aagggggtaa gctgttcctg agtataacac caagatgctg      600

ctgtctttat tcaaacacct ggcgtcggcc aacagccact tccagaaaaa tcttccagtt      660

tacgctgtag atggaacatg tttctgtgaa cctatcagtg gatttcattc tcttgagtaa      720

taaatcttat cttttcaag                                                   739


<210> 1752
<211> 3269
<212> DNA
<213> Homo sapiens

<400> 1752
cagggaaggt ggggctatgg cagctgctag ggaccctccg gaagtatcgc tgcgagaagc       60

cacccagcga aaattgcgga ggttttccga gctaagaggc aaacttgtag cacgtggaga      120

attctgggac atagttgcaa taacagcggc tgatgaaaaa caggaacttg cttacaacca      180

acagctgtca gaaaagctga aaagaaagga gttacccctt ggagttcaat atcacgtttt      240

tgtggatcct gctggagcca aaattggaaa tggaggatca acactttgtg cccttcaatg      300

tttggaaaag ctatatggag ataaatggaa ttcttttacc atcttattaa ttcactctga      360

tgaatggaag aaaaaagtca gtgaatcata tgttatcaca atagaaagat tagaagatga      420

cctgcagatc aaggaaaaag aactgacaga actaaggaat atatttggct ctgatgaagc      480

cttcagtaaa gtcaatttaa attaccgcac tgaaaatggg ctgtctctac ttcatttatg      540

ttgcatttgt ggaggcaaga aatcacatat tcgaactctt atgttgaaag ggctccgccc      600

atctcgactg acaagaaatg gatttacagc cttgcattta gcagtttaca aggataatgc      660

agaattgatc acttctctgc ttcacagtgg agctgatata cagcaggttg gatacggtgg      720

cctcactgcc ctccatattg ctacaatagc tggccaccta gaggctgctg atgtgctgtt      780

gcaacatgga gctaatgtca atattcaaga tgcagttttt ttcactccat tgcatattgc      840

agcgtactat ggacatgaac aggtaactcg ccttcttttg aaatttggtg ctgatgtaaa      900

tgtaagtggt gaagttggag atagacccct ccacctagca tctgcaaaag gattcttgaa      960

tattgcaaaa ctcttgatgg aagaaggcag caaagcagat gtgaatgctc aagataatga     1020

agaccatgtc ccactccatt tctgttctcg atttggacac catgatatag ttaagtatct     1080

gctgcaaagt gatttggaag ttcaacctca tgttgttaat atctatggag ataccccctt     1140

acacctggca tgctacaatg gcaaatttga agttgccaag gaaatcatcc aaatatcagg     1200

aacagaaagt ctgactaagg aaaacatctt cagtgaaaca gcttttcata gtgcttgtac     1260

ctatggcaag agcattgacc tagtcaaatt tcttcttgat cagaatgtca taaacatcaa     1320

ccaccaagga agggatgggc acactggatt acactctgct tgctaccacg gtcacattcg     1380

cctggttcag ttcttactgg ataatggagc tgatatgaat ctagtggctt gtgatcccag     1440

caggtctagt ggtgaaaaag atgagcagac atgtttgatg tgggcttatg aaaaagggca     1500

tgatgccatt gtcacactcc tgaagcatta taagagacca caagatgaat tgccctgtaa     1560

tgaatattct cagcctggag gagatggctc ctatgtgtct gttccatcac ccttggggaa     1620

gattaaaagc atgacaaaag agaaggcaga tattctcctc ctaagagctg gattgccttc     1680

acatttccat cttcagctct cagaaattga gttccatgag attattggct caggttcttt     1740

tgggaaagta tataaaggac gatgcagaaa taaaatagtg gctataaaac gttatcgagc     1800

caatacctac tgctccaagt cagatgtgga tatgttttgc cgagaggtgt ccattctctg     1860

ccagctcaat catccctgcg taattcagtt tgtgggtgct tgcttgaatg atcccagcca     1920

gtttgccatt gtcactcaat acatatcagg gggttctctg ttctccctcc ttcatgagca     1980

gaagaggatt cttgatttgc agtctaaatt aattattgca gtagatgttg ccaaaggcat     2040

ggagtacctt cacaacctga cacagccaat tatacatcgt gacttgaaca gtcacaatat     2100

tcttctctat gaggatgggc atgctgtggt ggcagatttt ggagaatcaa gatttctaca     2160

gtctctggat gaagacaaca tgacaaaaca acctgggaac ctccgttgga tggctcctga     2220

ggtgttcacg cagtgcactc ggtacaccat caaagcagat gtcttcagct atgctctgtg     2280

tctgtgggaa attctcactg gcgaaattcc attcgctcat ctcaagccag cggctgcggc     2340

agcagacatg gcttaccacc acatcagacc tcccattggc tattccattc ccaagcccat     2400

atcatctctg ctgatacgag ggtggaacgc atgtcctgaa ggaagacccg aattttctga     2460

agttgtcatg aagttagaag agtgtctctg caacattgag ctgatgtctc ctgcatcaag     2520

taacagcagt gggtctctct caccttcttc ttcttctgat tgcctggtga accggggagg     2580

acctggccgg agtcatgtgg cagcattaag aagtcgtttc gaattggaat atgctctaaa     2640

tgcaaggtcc tatgctgctt tgtcccaaag tgctggacaa tattcctctc aaggtctgtc     2700

tttggaggag atgaaaagaa gtcttcaata cacacccatt gacaaatatg gctatgtatc     2760

cgatcccatg agctcaatgc attttcattc ttgccgaaat agtagcagct ttgaggacag     2820

cagctgacag cattcggcgt atacctaagg agagtttttt ccccgaactg acagcaacga     2880

ttccaaccac ggcaagctgg cttccaacta taacatttta ctctcaaagg tctccttaaa     2940

ttgggcttgt ttttacttgt cctatttaat tccccactat tagcaggctt tggatttgtg     3000

cctaaggaat aatatgcaaa agaaccaaga cagaatgtat atgaagaatt gtttttaatt     3060

ttgtaaatta aaaaaaaatt tagatcgtta cttggaaatg gagcctaagt ctgtggtgga     3120

cagataataa ttatgttttc ctgggctgaa ttatgtagac ttgtgtttga cagctatggg     3180

tttatttctt agaacattgt tcattttctt ttctcattat gttacttcta gtgttcacct     3240

ctgtgattaa agattctttg gtgaaatag                                       3269


<210> 1753
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 1753
gtgctgtgcg gcgcggtctc agggaaggtg gggctatggc agctgctagg gaccctccgg       60

aagtatcgct gcgagaagcc acccagcgaa aattgcggag gttttccgag ctaagaggca      120

aacttgtagc acgtggagaa ttctgggaca tagttgcaat aacagcggct gatgaaaaac      180

aggaacttgc ttacaaccaa cagctgtcag aaaagctgaa aagaaaggag ttaccccttg      240

gagttcaata tcacgttttt gtggatcctg ctggagccaa aattggaaat ggaggatcaa      300

cactttgtgc ccttcaatgt ttggaaaagc tatatggaga taaatggaat tcttttacca      360

tcttattaat tcactctgta tctttccaga tataccagaa tgctctggca aaacatcctg      420

tatcattcaa agcatactgg attcaagatg ttctgtggca cctggctcag ttgtggagta      480

ttccagattg gggcctgatg tttcagttgg ggaaaactgc attattagtg gttcttacat      540

cctaacaaaa gctgccctcc ccgcacattc ttttgtatgt tccttaagct taaagatgaa      600

tagatgctta aagtatgcaa ctatggcatt tggagtgcaa gacaacttga aaaagagtgt      660

gaaaacattg tcagatataa agttacttca attctttgga gtctgtttcc tgtcatgctt      720

agatgtttgg aatcttaaag ttacagagga actgttctct ggtaacaaga catgtctgag      780

tttgtggact gcacgcattt tcccagtttg ttcttctttg agtgactcag ttataacatc      840

cctaaagatg ttaaatgctg ttaagaacaa gtcagcattc agcctgaata gctataagtt      900

gctgtccatt gaagaaatgc ttatctacaa agatgtagaa gatatgataa cttacaggga      960

acaaattttt ctagaaatca gtttaaaaag cagtttgatg tagagatatt ttaaatattg     1020

tacactttgc ctttttgagt aacattccag agataggtat tttttgtagg ctgtttcact     1080

gaactcagtt aatgaaaact gtattaacat aattgttgta gcataatatt aatagtgcaa     1140

aagtacatat aagtcatttt gatgaaaaat attccaagac taagttgaga aaagagatac     1200

tattttggat gtgtatcagt atttttgttt ttaataatga ttgatttgtg gagcattgtt     1260

ttttcacata attagtttta aaggtaattt tctaagcata cctttggaat ttttccatct     1320

tttttgaggc ttttggtcca gtgaagttct aagtattcac tggcacttct ctcctca        1377


<210> 1754
<211> 3224
<212> DNA
<213> Homo sapiens

<400> 1754
gcgtgctgtg cggcgcggtc tcagggaagg tggggctatg gcagctgcta gggaccctcc       60

ggaagtatcg ctgcgagaag ccacccagcg aaaattgcgg aggttttccg agctaagagg      120

caaacttgta gcacgtggag aattctggga catagttgca ataacagcgg ctgatgaaaa      180

acaggaactt gcttacaacc aacagctgtc agaaaagctg aaaagaaagg agttacccct      240

tggagttcaa tatcacgttt ttgtggatcc tgctggagcc aaaattggaa atggaggatc      300

aacactttgt gcccttcaat gtttggaaaa gctatatgga gataaatgga attcttttac      360

catcttatta attcactctg gtggctacag tcaacgactt ccaaatgcaa gtgctctggg      420

aaaaattttc actgctttac ctcttggtaa ccccatttat cagatgctag aattaaaact      480

agccatgtac attgatttcc ccttaaatat gaatcctgga attctggtta cctgtgcaga      540

tgatattgaa ctttatagta ttggagaatt tgagtttatt aggtttgaca aacctggctt      600

tactgcttta gctcatcctt ctagtttgac gataggtacc acacatggag tatttgtctt      660

agatcctttt gatgatttaa aacatagaga ccttgaatac aggtcttgcc atcgtttcct      720

tcataagccc agcatagaaa agatgtatca gtttaatgct gtgtgtagac ctggaaattt      780

ttgtcaacag gactttgctg ggggtgacat tgccgatctt aaattagact ctgactatgt      840

ctacacagat agcctatttt atatggatca taaatcagca aaaatgttac ttgcttttta      900

tgaaaaaata ggcacactga gctgtgaaat agatgcctat ggtgactttc tgcaggcttt      960

gggacctgga gcaactgtgg agtacaccag aaacacatca aatgtcatta aagaagagtc     1020

agagttggta gaaatgaggc agagaatatt tcatcttctt aaaggaacat cactaaatgt     1080

tgttgttctt aataactcca aattttatca cattggaaca accgaagaat atttgtttta     1140

ctttacctca gataacagtt taaagtcaga gctcggctta cagtccataa cttttagtat     1200

ctttccagat ataccagaat gctctggcaa aacatcctgt atcattcaaa gcatactgga     1260

ttcaagatgt tctgtggcac ctggctcagt tgtggagtat tccagattgg ggcctgatgt     1320

ttcagttggg gaaaactgca ttattagtgg ttcttacatc ctaacaaaag ctgccctccc     1380

cgcacattct tttgtatgtt ccttaagctt aaagatgaat agatgcttaa agtatgcaac     1440

tatggcattt ggagtgcaag acaacttgaa aaagagtgtg aaaacattgt cagatataaa     1500

gttacttcaa ttctttggag tctgtttcct gtcatgctta gatgtttgga atcttaaagt     1560

tacagaggaa ctgttctctg gtaacaagac atgtctgagt ttgtggactg cacgcatttt     1620

cccagtttgt tcttctttga gtgactcagt tataacatcc ctaaagatgt taaatgctgt     1680

taagaacaag tcagcattca gcctgaatag ctataagttg ctgtccattg aagaaatgct     1740

tatctacaaa gatgtagaag atatgataac ttacagggaa caaatttttc tagaaatcag     1800

tttaaaaagc agtttgatgt agagatattt taaatattgt acactttgcc tttttgagta     1860

acattccaga gataggtatt ttttgtaggc tgtttcactg aactcagtta atgaaaactg     1920

tattaacata attgttgtag cataatatta atagtgcaaa agtacatata agtcattttg     1980

atgaaaaata ttccaagact aagttgagaa aagagatact attttggatg tgtatcagta     2040

tttttgtttt taataatgat tgatttgtgg agcattgttt tttcacataa ttagttttaa     2100

aggtaatttt ctaagcatac ctttggaatt tttccatctt ttttgaggct tttggtccag     2160

tgaagttcta agtattcact ggcacttctc tcctcaactg taattctatt tttaataata     2220

aaaatggcat actgtagggt cttcagagta gtgtaggaat actgtagaaa tactttttca     2280

gaaacgaatc catagctgac aaattcactc agtgcccaat atattgtgat tattttcgtt     2340

gataaagaac tagatacaaa gacctctgaa attgatgata aaatttgtat ctcattaatt     2400

ttatcaaaat gaaactaaaa gtacatatgt attatacact tgaacatgtg tttgtatatc     2460

tttaaaattt tcctttatgt tccattccat aggaaaacac acatatgcac acaaaactca     2520

gttatctgtg gggaaagtgg tagtaataat tgagattcat caataatcat ataatttcac     2580

tatagacatt acttgcatta tctcctatca gtccttctaa caaaacttca attaccagat     2640

gaactgactt tagttttcat cttatttttt gtccacatgc tggtgatgct gagaaacaat     2700

aattggccca aatgcagaca tcaagaagca ggcaggaaaa tggaaaaact gagataatac     2760

acaggtgata aacagtttcg agaaaataaa aattggctag aatctcaagt tatgtgtttc     2820

tatattggta taagcatata agtgaaaagt cttataagtg taatagagaa aagatttgtc     2880

agtgtgtttt tttaaatgaa ataactagtc tgtgctactt tatgtcaata taaaaattgg     2940

taaactagaa gtaacttgtc cacaaccctc agttatgata cttatgtgcg tgtttttttt     3000

tccaaagttt ttcccaagga gaagatacaa atatatggta gctattgttt aaaaatgatt     3060

gatttacttg cagatttttc agaggatgtt atgtctttgt cattcattaa atgttcaaaa     3120

ttgtagtttt accaaatctg aagtgccatc agttataaga atcaccatta ttttatgttc     3180

cattaagaaa aacacaataa aacatgacac tgcttttttt gtta                      3224


<210> 1755
<211> 923
<212> DNA
<213> Homo sapiens

<400> 1755
gttttcatcc tggttttggg acagcggcaa tcatggcgcc acctgtgaga tactgcatcc       60

ccggcgaacg tctgtgtaac ttggaggagg gcagcccggg cagcggcacc tacacccgcc      120

acggctacat cttttcgtcg cttgccggct gtctgatgaa gagcagcgag aatggcgcgc      180

ttccagtggt gtctgtagtg agagaaacag agtcccagtt actgccagat gtgggagcta      240

ttgtaacctg taaggtctct agcatcaatt cacgctttgc caaagtacac atcctgtatg      300

tggggtccat gcctcttaag aactcttttc gaggaactat ccgcaaggaa gatgtccgag      360

caactgaaaa agacaaggtt gaaatttata agagtttccg cccaggtgac attgtcttgg      420

ccaaagtgat ctccttaggt gatgcacagt ccaactacct gctaaccacc gccgagaacg      480

agctgggagt ggtggtagcc cacagtgagt caggtatcca gatggttccc atcagctggt      540

gtgagatgca gtgccctaag acccacacta aagaattccg gaaagtagcc cgagtacaac      600

ccgaattctt gcagacctaa gaagccactt tttaccctat ggaagggggt aagctgttcc      660

tgagtataac accaagatgc tgctgtcttt attcaaacac ctggcgtcgg ccaacagcca      720

cttccagaaa aatcttccag tttacgctgt agatggaaca tgtttctgtg aacctatcag      780

tggatttcat tctcttgagt aataaatctt atcttttcaa ggcaccaaca aacaaaactg      840

tgatattgga aatagcctat ccctcctgac agtccttata aatacatatt ttttgctatg      900

ataaaacttt tttactaaaa gga                                              923


<210> 1756
<211> 4069
<212> DNA
<213> Homo sapiens

<400> 1756
gagcaagagg aagatggccg tgccctgttt ttcggtgtaa ggcagcgacg gcggctgcga       60

cggcgagact gagatcctgg tgtcgtgggc acctgagttc tagcttcccc cagcgagcgc      120

gcgtcccttc gtgcctaggc gagagccggc tcttccccgg gagatgcgtt tgtcccaggc      180

tcgggggctc agtgggagtt catgctgcgc tggaggctct tggccaccgc tctaatcgcc      240

ttgtgccgcc gcagcgccag ctccgtcgcc agcggtgagc ctcccgattc ccccccttgc      300

ccctggcggc ggcgatgacc ggggagaaga tccgctcact gcggagggac cacaagccca      360

gcaaagaaga aggggacctg ctggagcccg gggatgagga agcggcggct gccctcggcg      420

gtacctttac cagaagcagg attggcaagg gcggcaaagc ttgtcataag atcttcagta      480

accatcacca ccggctacag ctgaaggcag ctccggcctc ctccaatccc cccggcgccc      540

cggctctgcc gctgcacaat tcctccgtga ctgccaactc ccagtccccg gcccttctgg      600

ccggcaccaa ccccgttgct gtcgtcgcgg atggaggcag ttgccccgca cactacccgg      660

tgcacgagtg cgtcttcaag ggggatgtga ggagactctc ctctctcatc cgcacgcaca      720

atatcgggca gaaagataat cacggaaata ctcctttaca ccttgctgtg atgttaggaa      780

ataaagaatg tgcccattta cttttggctc acaatgctcc agtcaaggtg aaaaatgctc      840

agggatggag ccctctggcg gaagccatca gctatggaga taggcagatg attacagctc      900

ttttgaggaa gcttaagcag caatccaggg aaagtgttga agaaaaacga cctcgattat      960

taaaagccct gaaagagcta ggtgactttt atctagaact tcactgggat tttcaaagct     1020

gggtgccttt actttcccga attctgcctt ccgatgcatg taaaatatac aaacaaggta     1080

tcaatatcag gcttgacaca actctcatag actttactga catgaagtgc caacgagggg     1140

atctaagctt cattttcaat ggggatgcgg cgccctctga atcttttgta gtattagaca     1200

atgaacaaaa agtttatcag cgaatacatc atgaggaatc agagatggaa acagaagaag     1260

aggtggatat tttaatgagc agtgatattt actctgcaac tttatcaaca aaatcaattt     1320

ctttcacgcg tgcccagaca ggatggcttt ttcgggaaga taaaacagaa agagtaggaa     1380

actttttggc agacttttac ctggtgaatg gacttgtttt agaatcaagg aaaagaagag     1440

aacatctcag tgaagaggat attcttcgaa ataaggccat catggagagt ttgagtaaag     1500

gtggaaacat aatggaacag aattttgagc cgattcgaag acagtctctt acacctcctc     1560

ctcagaacac tattacatgg gaagaatata tatctgctga aaatggaaaa gctcctcatc     1620

tgggtagaga attggtgtgc aaagagagta agaaaacgtt taaagctacg atagccatga     1680

gccaggaatt tcccttaggg atagagttat tattgaatgt tttagaagta gtagctccct     1740

tcaagcactt taacaagctt agagaatttg ttcagatgaa gcttcctcca ggctttcctg     1800

taaaattaga tatacctgtg tttcccacaa tcacagccac tgtgactttt caggagtttc     1860

gatacgatga atttgatggc tccatcttta ctatacctga tgactacaag gaagacccaa     1920

gccgttttcc tgatctttaa ctgacgtgga aaaggatgcc gtctaaccaa ggaaagaaaa     1980

tacagagacc ctagaagtgg atccaaatag aagggacaaa tgctttcagt gaagaaaagg     2040

gaattacaca ttgaatcgac acatcagtaa tacgatacag tgaaatgggc ctctaataag     2100

aatttcagcg agttttctga tgtgccattt tttgtctttt taaaaatata catattataa     2160

atgtaatagt ttgacacatt aatgacccta agacctgcgt atgtgaagca gctatgagtg     2220

ctgtgatttg tttttaaaaa tttttacact tcttgttgaa atatatatgc atataaatat     2280

atctatatct atatctatat ctaaaacact cctggaccat taacgtaaat taaatgtctt     2340

aagagatatg gagccctttt aaacttgtca tctttatgca aggtgacatt tataaatatt     2400

ccttcgagct ttgttttcat aaaatgtaaa ctatgtaaca ttatgtatag ttcagtaatt     2460

tgaatgtttg ttcaatataa tgaactagaa ggaatgcaat tttctgtaga tgaatgaacc     2520

aaatggtaac cattaaacaa ttgcatttat atgttgcaat acatttcaga aggagcgttc     2580

actctgcagg gaataaggta cctcctttag caccttagtg caattcattg tggtgctatt     2640

tgtttttacc tgaatgtttg ttactaatct tcctttcata gaacctctat tttttttttt     2700

tctaaacttg agtttgagtc cttgttatgg tcatcataag gtaatggtta gcatgtttaa     2760

agatattcct cttccaaatc tcagcacttt aaaaaaaaat ccaaattttt aaacttgctt     2820

cctaataagt acacatcggt ctgattattt tgtttgtttt tagtagaata tggatgcatt     2880

ggtgtcagtt ttaaaaaaca atacacatat tttggacaac cctacatatt taatcctttc     2940

aaaataagat aaaaacattt tatatgctaa cagaatatat ttgttacaag ttaaagtcca     3000

gaagtataca caagattgat tactcctatt atttttttta aatcacagga aaatattgat     3060

ttcattgtct ccaaagtgat aaaatcatgt attactcatt tttgcactta aaatttttct     3120

tatttattcc aaggtggttt gaaggtccaa gtatgaaaat aaattagggg gattaatgta     3180

taacagttat aaagtatcat gttgtattaa agagcttact tagattgatg tttttaaaat     3240

gtatcctgat gaatgtctca agaatgcatc tgtcaagttt tttagactga ccagtagctt     3300

aaactttttt caggatttta ggtaatttga aaggagttta gagaccctta ttgaaaatat     3360

gatttaaaaa tccaaagcat aaaccgtaag aaaaatttta aataaacatc tttaaagctg     3420

catcttccat actgatacat gcattgcgta tgttgacatt aaatacattt tataatgaag     3480

aaaaataatc atagtaaaaa attgaaagac ctaattacta cgttacatgg acctattgaa     3540

ttttggggga acgtgttagt aaacccagac tagctttgtt gaatagaagt tgatcgctgt     3600

tatttaggaa atgggtagat caaatgactt agagactgaa ttatcctatc agtggttaca     3660

tggggttgga gacactgaaa ggcagtgatc actgttgctt ctaggctccc ttactttgta     3720

ggaatatggt atactttcag gaatatgcta tatatgtttt cataagtaca gacaccttag     3780

ggaagaaaaa aagtgggtaa ttgaagctta tggttgatta atttcctaac agcacagcta     3840

tgaatatttt gctggggtac actggaggta ggaagactac tggaaatttt tgcacttgaa     3900

ttttgttttt aaagcttttt tctttaaaga atggtagaaa cagattatcc attccaaaat     3960

gtcttttctc tgatcacaaa gagcaaacaa atgtcaatat ctcttatgat ggtgaaaaaa     4020

aggaattaat cgatgcaaat aaacttttca cagtattact tttaatgaa                 4069


<210> 1757
<211> 2651
<212> DNA
<213> Homo sapiens

<400> 1757
ggattccggc tcccgcggct gcaggcgcgc ggctagagtg cctggcgggc tccggcttcc       60

gcgtccgccc cggccccggt ccagacttag tcttcagctc cgcgcccgct ccgccgcggc      120

ccaccgcgcc cgccggcagc cgagccccca gcgacgcccg cacagctccg ggtgcccaga      180

cagggggcca tgccgtgccg gagggaggag gaagaggaag ccggcgagga ggcggagggg      240

gaggaagagg aggaggacag cttcctccta ctgcagcagt cagtggcgct gggcagctcg      300

ggcgaggtgg accggctggt ggcccagatc ggcgagacgc tgcagctgga cgcggcgcag      360

cacagcccgg cctcgccgtg cgggcccccg ggggcgccgc tgcgggcccc ggggcccctg      420

gctgcggcgg tgccggcgga caaggccagg tccccggcgg tgccgctgct gctgccgccc      480

gcgttggcgg agactgtggg cccggcgccc cctggggtcc tgcgctgcgc cctgggggac      540

cgcggccgcg tgcggggccg cgctgcgccc tactgcgtgg ccgagctcgc cacaggcccc      600

agcgcgctgt ccccactgcc ccctcaggcc gaccttgatg ggcctccggg agctggcaag      660

cagggcatcc cgcagccgct gtcgggtccg tgccggcgag gatggctccg gggcgccgcc      720

gcctcccgcc gcctgcagca gcgacgcggg tcccaaccag aaacccgcac aggcgacgac      780

gacccgcacc ggcttctgca gcagctagtg ctctctggaa acctcatcaa ggaggccgtg      840

cgaaggcttc attcgcgacg gctgcagtta cgtgcaaagc ttccccaacg cccgctcctg      900

ggacctctgt cggccccggt gcatgaaccc ccttcgcctc gcagccctcg cgcggcctgc      960

agtgaccctg gcgcctccgg gagggcgcag ctcagaactg gcgacggcgt tcttgtgcct     1020

ggcagctaac acgcccgggg tggccacagc gccagcctca gactggaggg caaggggttc     1080

ccttgagggc tgcagttcta ctcaggctgg tggagaactc tggcttttgg aagcgagagt     1140

aaaaagctaa tgacgaggaa ccgaaaaatc gcgagtgttt cgcgggtaac tggggttgag     1200

ggccaaaata tttggaatga aggactttgg ccctatttaa ggcagatttt acagagcgca     1260

cctcaaacgt acaagtcagt aggactcctt atttggcgtg acccgacctg gccgcggagc     1320

ctgcatttcc tcgcagcctc tcagtgccct ccagccccgc gaccatgtgg ccacaatcca     1380

cgcttctccg gatcgcggtg cgccggaacc acggaggatg atgccagtta cttgctttac     1440

cttttcaggg ctggctcctg atccactttg ggggaggaga acatgagtag ataatttcag     1500

ggtgcagccc aatctgccag acttaaaaaa accatcttgt gtctttggag gtgctgctta     1560

ataccaaaca tgcggtgcca tgaagggacc ctttgggggt tgaataggag ttaacccctg     1620

cgctctcttt gcaactgtct ctcttctcag agtggtgggg gaaggctgta cgacacgggt     1680

ggggaaagga ggtgggggcg gggagtattg aatggtggtg gaagggtaga gaggcgcgga     1740

gtgaacccca cgccctgtct aaagtgtatt ttcagagccg gcccgcctct cctcggttca     1800

aggtcactgt ttcctgggca cgcactgggt tgcgggacag agtagccagg ttctgccggt     1860

gctcggagaa gagcgcagtg ttttgcaagt gctggagtct cctgaggaca cgcgcgtcgc     1920

cgccaccgcg ggtgtgggaa agcgcggacg tgctgggcgg ctgtgcttcg gtaggcgacc     1980

accgcccctg gccgcgctcc gggctttcac ggaaactccc gagaccgggc cctgggttcc     2040

tcctctccta ctcggctctg cagtcctact caagcgggtg gctctgggat cctgggggcc     2100

tgggttgggg gctagggaga cgccatgtga tggacactcc agggacacac agcctagcac     2160

agcagcttat aatgggctct ccggggccat ttgcaataac agctgcaatt ccctggatag     2220

acgagttgat ttcctccctc tgcccctccc ccagccatgc cagctggcct ttgtaagtgc     2280

aggaaaccga gtagaaaatg tgaccctcca aatggagaag ctgcaggctt tgccattgtg     2340

aaccatggtg aagtgcttgg aacatactgt tcactcactc taaaggcgct gagactgtgc     2400

tgttgttctc gtttttatag tcaatggctt gttcatcatc cagatgtggc tactgacata     2460

tctacacttc gcaccggagt gtctggaatt gtggctatcc tgattatagg attttaactt     2520

aactgaaatg cctgctttga ataaatgtgt tgggtttttt gtttggtttt attttatact     2580

tgccatcagt gaaaaagatg tacagaacac atttctctga tctccataaa catgaaaaca     2640

cttgaaatct c                                                          2651


<210> 1758
<211> 1931
<212> DNA
<213> Homo sapiens

<400> 1758
gtgcgacggt cacctcggtt tgggtgagtc cctgggttcg agcccgggcc ccgccagctg       60

ccgagttgcc tctcggtgcc ggactgtgac tccctctggc cggccctgca ctctggcctc      120

ctgggacgtc atctggaggg atagagccag gcctgggact ccttttggga gagtttccgt      180

tcttctattc cgtgctgtcc ggccaggacc cctcagggac ttctgtgggg caggggcgaa      240

tcatgcatgg cctagatgac cccatgccta gaaaaaggca gtgcggggcg gtggcggcgc      300

gcacggccga gtgaagcaga tagcgtcccc ggggctggag cccggtagca gggccgggcg      360

ttgtggcgcg tgcctgtaat cccagctact cgggaggctg aggcaggaga atcgcttgaa      420

tccgggagat ggaggttgca gtgagccgag atcatgccac tgcactccag cctgggcaac      480

aagagcgaaa ctctgtctca aaaaaaaaac aacaacaaca aagaaaaaac aaaacgaaac      540

agcaggaacc cgccaagaac agccttgaag gaagggaaga tggaagagtt gagtcaggcc      600

ctggctagta gcttttctgt gtctcaagat ctgaacagca cagctgcccc acacccccgc      660

ctatcccagt acaagtccaa gtacagttcc ttggagcaga gtgagcgccg ccggaggtta      720

ctggaactgc agaaatccaa gcggctggat tatgtgaacc atgccagaag actggctgaa      780

gatgactgga cagggatgga gagtgaggaa gaaaataaga aagatgatga agaaatggac      840

attgacactg tcaagaagtt accaaaacac tatgctaatc aattgatgct ttctgagtgg      900

ttaattgacg ttccttcaga tttggggcag gaatggattg tggtcgtgtg ccctgttgga      960

aaaagagccc ttatcgtggc ctccaggggt tctaccagtg cctacaccaa gagtggctac     1020

tgtgtcaaca ggttttcttc acttctgcca ggaggcaaca ggcgaaactc aacagcaaaa     1080

gactacacca ttctagattg catttacaat gaggtaaacc agacctacta cgttctggat     1140

gtgatgtgct ggcggggaca ccctttttat gattgccaga ctgatttccg attctactgg     1200

atgcattcaa agttaccaga agaagaagga ctgggagaga aaaccaagct taatcctttt     1260

aaatttgtgg ggctaaagaa cttcccttgc actcccgaaa gcctgtgtga tgtgctatct     1320

atggatttcc cttttgaggt agatggactt ctcttctacc acaaacagac ccactacagc     1380

cccggaagca ctcccttggt gggctggctg cgcccctaca tggtgtcaga tgtccttggt     1440

gtagctgtgc cggctggccc gctgaccacc aagccagact atgctgggca ccagctccag     1500

cagattatgg agcacaagaa gagccagaag gaaggcatga aggagaaact cacacacaag     1560

gcctctgaga atgggcacta tgaattggag cacctgtcta ctcccaagtt gaagggttct     1620

tcccatagcc cagaccaccc tggatgcctc atggagaatt aaagagagaa gcctccttaa     1680

ggagccacag gatggtacct ggccccaaaa ggaatcctgg agaggaggac agtgacaaca     1740

ggtgacttca ttctttagag tgaactttcc aaacccagtc cagctggaaa cagcttatct     1800

ataatctgaa atgctggctc aaacagttat ggggaggttc ccagattgcg tagcattcag     1860

attgatttga gcagctccta ctgtgataag tgtatcccag atccacaatg taaatatatg     1920

tgatttgtaa g                                                          1931


<210> 1759
<211> 2362
<212> DNA
<213> Homo sapiens

<400> 1759
cgcaggaagt ggctccaggg cgcacgcgcg ttgtttccgc ggtagtcagg gcagtttcta       60

ccgcaggctt aaggaggctt cgggctcctg ggatttctgt ccgcgctcct ggccctcgtc      120

cttcgcgcca gagcaggttc aaaatgagcc tgtttggaac aacctcaggt tttggaacca      180

gtgggaccag catgtttggc agtgcaacta cagacaatca caatcccatg aaggatattg      240

aagtaacatc atctcctgat gatagcattg gttgtctgtc ttttagccca ccaaccttgc      300

cggggaactt tcttattgca ggatcatggg ctaatgatgt tcgctgctgg gaagttcaag      360

acagtggaca gaccattcca aaagcccagc agatgcacac tgggcctgtg cttgatgtct      420

gctggagtga cgatgggagc aaagtgttta cggcatcgtg tgataaaact gccaaaatgt      480

gggacctcag cagtaaccaa gcgatacaga tcgcacagca tgatgctcct gttaaaacca      540

tccattggat caaagctcca aactacagct gtgtgatgac tgggagctgg gataagactt      600

taaagttttg ggatactcga tcgtcaaatc ctatgatggt tttgcaactc cctgaaaggt      660

gttactgtgc tgacgtgata taccccatgg ctgtggtggc aactgcagag aggggcctga      720

ttgtctatca gctagagaat caaccttctg aattcaggag gatagaatct ccactgaaac      780

atcagcatcg gtgtgtggct atttttaaag acaaacagaa caagcctact ggttttgccc      840

tgggaagtat cgaggggaga gttgctattc actatatcaa ccccccgaac cccgccaaag      900

ataacttcac ctttaaatgt catcgatcta atggaaccaa cacttcagct cctcaggaca      960

tttatgcggt aaatggaatc gcgttccatc ctgttcatgg cacccttgca actgtgggat     1020

ctgatggtag attcagcttc tgggacaaag atgccagaac aaaactaaaa acttcggaac     1080

agttagatca gcccatctca gcttgctgtt tcaatcacaa tggaaacata tttgcatacg     1140

cttccagcta cgactggtca aagggacatg aattttataa tccccagaaa aaaaattaca     1200

ttttcctgcg taatgcagcc gaagagctaa agcccaggaa taagaagtag tggctggaga     1260

ctctggctca gccagagttg tttctctcca ctctgcctca tctctgtacg aatttgggtc     1320

ccagccttgt tgggttgtca gccatggaca tggatttcaa cccctggaga aaacgatgtc     1380

attgttcagc agctgagagc ccaggcgtcc gcggcgactt gccgtctctc cattccactg     1440

cctgttgcag agtttttctg taactaaggg ggttgaggtt attgtagacg ttagattgcg     1500

ggcaccgcca gggattttgc agcgcttcag tgtacgtgtt agagaatatt ggaaaagcgt     1560

ctgtgagccc cgtgctgtat tttgtaataa agtcttttgc agattgcttc ccgagcttcc     1620

tttgtccttt tctccccttg cccaccccgt aacctcagga acatgcgtcc tgcccagcat     1680

cagcgtgggg ttttgagttg agatttcaga caccctctgg gaaatgcggc aaccttaggg     1740

gaaagggagt ccccagctgc gctcacttct gctgcgcgga acggcagcct ctgtgagccc     1800

tggtgggcag agtttgaatg tgtttttcct tgcttccctc attcccatct tcaaaatccc     1860

cagtgctttc tggccttgct gctcagattt ccgagtgact caaatgggga ctgttacttg     1920

tgctgggtga caggccattt gtgggtaacc tcctaaggcc caagtgggtg acacttgcgt     1980

gactttcaag ttagaaccca agccccctgc atgggaattg ccctgaactc ttacccaccc     2040

cggtcccctg catgggaatt gccctgaacc ctcagtagtg gttgtttggc tgttcttttg     2100

tattttgtgt aatttaaaat tcctggttgg taagtattca aaatgaaatt cagctgggct     2160

gagaaaaagt gtgacttttg ggtctgtcac tgtatttctc acctgtgatc tcaaatgctt     2220

cttaggcctt tctgtttgga ctaatgtgtg aagtctgact tgctgagtgt aaaattctag     2280

tatcgatagt gttgtaagat gtgtttgcct actcataaaa aacaatgaaa ataaaatttt     2340

ctactggaag agaccacctg ca                                              2362


<210> 1760
<211> 3679
<212> DNA
<213> Homo sapiens

<400> 1760
tagtaacaag tgatgatctg cttccaatac ctagtgatgc atatgatgtc ttacttttgc       60

ccatgcaagc tgtcagatgt tcattatctg atattcctga tcatatacca gaagaagtgg      120

tggtgtggtt tcaggagact attttagata agtcattgaa ggctttagtt gtagcaaaag      180

atccagatgg aacactgatt atagaactat atggtgacaa tattcaaatt agtgctagta      240

ttaataagaa gttggggcta cttagttaca aagatagaat aagaaaaaaa gaaagtgaag      300

tcctctgttc tacaactgaa actcttgaag aaaaaaatga gaatatgaag ttgccatgta      360

cagagtattt aagtaaatca gtagggtaca agttacctaa taaagaaatt ttggaagagt      420

catataaacc tcagatcaac tcatcataca aggaactcaa acttttacaa agtttaacaa      480

aaacaaactt agtcactcaa tatcaagact ctgtgggaaa taaaaatagt caagtgtttc      540

cattaacaac agaaaagaaa gaagaaattt ctgctgagac acccttgaaa acagcaagag      600

tagaagctac tctttcagag agaaaaatag gagattcatg tgacaaagat ttgcctctga      660

aattttgtga gttcccacag aagactataa tgcctggatt taaaacaact gtatatgttt      720

ctcatataaa tgacctttca gacttttatg ttcaactaat agaagatgaa gctgaaatta      780

gtcatctttc agagagatta aacagtgtta aaacaaggcc cgaatattat gtaggtccac      840

ctttgcaaag aggagatatg atatgtgctg ttttcccaga agataattta tggtatcgtg      900

ctgtgatcaa ggagcaacaa cccaatgacc ttctctctgt gcagtttata gattatggca      960

atgtttctgt ggttcatact aacaaaatag gtaggcttga ccttgttaat gcaatattgc     1020

cggggttgtg cattcattgc tccttgcagg gatttgaggt tcctgacaat aaaaattcta     1080

agaaaatgat gcattacttt tcccaacgga ccagcgaggc tgcaataaga tgtgaatttg     1140

ttaaatttca agacagatgg gaagttattc ttgctgatga acatgggatc atagcagatg     1200

atatgattag caggtatgct ctcagtgaaa aatctcaagt agaactttct acccaagtaa     1260

ttaaaagtgc cagttcaaag tctgttaaca aatcagacat tgacacttca gtatttctta     1320

actggtataa tccagaaaaa aaaatgataa gagcttatgc cactgtgata gatggacctg     1380

agtacttttg gtgtcagttt gctgatacgg agaaacttca gtgtttagaa gtagaagtac     1440

agactgctgg agaacaggta gcagacagga gaaattgtat cccatgtcct tatattggag     1500

atccttgtat agtaagatac agagaagatg gacattatta tagggcactt atcactaata     1560

tttgtgaaga ttatcttgta tctgtcaggc ttgtggactt tggaaacatt gaagactgtg     1620

tggacccaaa agcactctgg gccattcctt ctgaacttct gtcggttccc atgcaagcct     1680

ttccatgttg cctctcaggg tttaacattt cagaaggatt atgttctcaa gagggaaatg     1740

actatttcta tgaaataata acagaagatg tgttggaaat aacaatacta gaaatcagaa     1800

gggatgtttg tgatatccct ttagcaattg ttgacttgaa aagcaaaggt aaaagtatta     1860

atgagaaaat ggagaaatat tctaagactg gtattaaaag tgctcttccc tatgaaaata     1920

ttgactcaga gataaagcag actcttgggt cctacaatct tgatgtagga cttaagaaat     1980

taagtaataa agctgtacaa aataaaatat atatggaaca acagacagat gagcttgctg     2040

aaataactga aaaagatgta aacattattg gaaccaaacc aagtaacttc cgtgacccta     2100

aaactgataa catttgtgaa gggtttgaaa acccctgcaa agataaaatt gatactgagg     2160

aactggaagg tgaattagag tgccatctgg ttgacaaagc agagtttgat gataaatacc     2220

tgattacagg atttaacaca ttactaccac atgctaatga aacaaaggag atactagaac     2280

tgaattcact tgaggtgccg ctttctcctg atgatgaatc aaaagaattc ttagaactgg     2340

aatctattga gttacagaat tctctggtgg tggatgaaga aaaaggggag ctaagcccgg     2400

tgccaccgaa tgtgccactc tcccaagagt gtgtcacaaa aggcgccatg gagctattta     2460

cactgcagct tcctctcagc tgtgaagctg agaaacagcc agaactagaa ctacctacag     2520

cccagctgcc tttagatgac aagatggatc ctttgtcttt aggagttagt cagaaagcac     2580

aggaatccat gtgtactgag gacatgagaa agtcaagttg tgtagaatct tttgatgacc     2640

agcgcaggat gtcattgcat ctacatggag cagattgtga tcctaaaaca cagaatgaaa     2700

tgaatatatg tgaagaagaa tttgtagagt ataaaaacag ggatgccatt tcggcattga     2760

tgcctttgtt ctctgaggaa gaaagcagtg atggaagcaa gcacaataat ggtttaccag     2820

atcatatctc agctcaacta cagaacacct acactctgaa agcctttact gttggatcta     2880

aatgtgttgt gtggtcaagt ctaagaaaca catggtctaa atgtgagatt ttagaaacag     2940

ctgaagaagg aacaagggtt ttgaaccttt caaatggtat ggaggagata gtgaaccctg     3000

agaatgtctg gaatggcata cccaaattgg ataagagtcc acctgaggct gtatcccaaa     3060

gagtagggaa agatctttac ttcatgtcag tgggtgatac cactattaaa gaaaaggggt     3120

ttggaggtga tggagattta accgtggatc tatagctgtg gccaatcagt cagaagctgc     3180

ccttgaacaa gtggcatctt acgcagacca acagagtatt tgagaaaatt gaaaacatgt     3240

aaccacaaga agttgtcatt ttcaaaaact tctatatagg tggaaaacaa attaggtctc     3300

aggttgatgg tggggtgtgt ttatagtgat cctgttatat atacagatct gggatctttc     3360

gtctttattg tcttacgttt ctaattagtt gggaggattt attttgctaa acagtttact     3420

aacacattac atttcaaaaa ctattttggt acctttcaaa tacagtgttt aaattaaaat     3480

agaaaaataa gggctcatga caagtacatt atttgattct acttaggata gctttttagc     3540

aggatctcct tcagaatttt tgtcttgact ttgaatcttt gcctgtttgt ctaaacattt     3600

gactaacatt ctgtttgaat ttggaagtat tctaatacaa gatttgaata aagtttatcc     3660

ttaaataaag tttatcctt                                                  3679


<210> 1761
<211> 2497
<212> DNA
<213> Homo sapiens

<400> 1761
aaggcggagc ggtccctgca acccggccgg cgggaactgc cttctagttt ttagtctcag       60

accagaccac cgggcgcacc ccgatgccga gcccgcagct tctggtgctc ttcggcagcc      120

agacaggcac ggctcaggat gtgtcggaga gactgggtcg cgaggcccgg cgccggcggc      180

ttggctgccg ggtgcaggcc ctggactcct acccggtggt gaatctgatt aacgagcccc      240

tggtgatatt tgtttgtgca actacaggcc aaggagaccc ccctgacaac atgaagaact      300

tctggaggtt tatattccgg aagaacctgc cctccactgc cctctgtcag atggactttg      360

ccgtcctggg cctcggggac tcctcatacg ccaagttcaa cttcgtggcc aagaagctgc      420

accgacggct actgcagctt gggggcagcg ccctcctgcc cgtgtgcctg ggcgatgacc      480

agcatgagct ggggcccgac gctgctgtgg acccctggct gcgagacttg tgggacaggg      540

ttctggggct gtacccgccg cctccgggcc tcactgagat ccctcccgga gtccccctgc      600

cctccaagtt caccctgctg ttcctccaag aggcacccag cacgggctct gaggggcagc      660

gggtagctca ccccggctct caggagcccc cgtcagagtc gaagcccttc ctagcaccca      720

tgatctccaa ccagagagtc accggcccct cccacttcca ggacgttcgg ctgattgagt      780

ttgacatctt gggctctggc atcagctttg ctgctggtga tgtggtgctg attcagccct      840

ccaactcggc tgcccatgtc cagcggttct gccaggtgct gggcctggac cctgaccagc      900

tcttcatgct gcagccgcgg gagccagatg tctcctcccc cacgaggctg ccccagccct      960

gctccatgcg gcacctcgtg tcccactacc tggacatcgc cagcgtgcct cgccgctcct     1020

tcttcgaact cctggcctgt ctatccctcc atgagctgga gcgggagaag ctgctggagt     1080

tcagttctgc ccaaggccag gaggagctct ttgaatactg caaccggccc cgcaggacca     1140

tcctggaggt gctctgtgac ttcccgcaca cagctgccgc catccctccc gactacctgt     1200

tggacctcat ccccgttatc cggccgaggg ccttctccat cgcctcctcg ctgctgactc     1260

acccctcacg gctgcagatc ctcgtggctg tagtgcagtt ccagactcgc ctcaaggagc     1320

cccgccgggg cctctgctcc tcctggctgg catccctgga ccctgggcaa ggacctgtcc     1380

gggtgcccct ctgggtgcgg cctgggagtc tggccttccc agagacacca gacacacctg     1440

tgatcatggt ggggcctggc actggggtag cccccttccg agcagccatc caggagcgtg     1500

tggcccaggg ccagactgga aacttcttgt tttttggctg ccgctggcgg gaccaagact     1560

tctactggga ggctgagtgg caggagctgg agaagcggga ctgtctgacc ctcatccctg     1620

ccttctcccg ggaacagccc ccagccctgt tctctgccct acaggagcag aaagtatatg     1680

tgcagcaccg gctccgggag ctggggtcgc ttgtgtggga actgctggac cgccagggtg     1740

catacttcta cctggcaggc aacgccaagt ccatgccagc ggacgtctcg gaagccctga     1800

tgtccatctt ccaggaggag ggtggactct gcagcccgga cgcagccgcg tatctagcca     1860

ggctccagca gacacggcgc ttccagacag agacgtgggc ctgaggcccg cggctgcccg     1920

tgccccctct gacagccatc ctcctgggag cccaggaagg catccacgag ggagctcctg     1980

gccagcagcc gtcatcctct cggaccagcc agctggtcct ctgggaacag ccagctcccg     2040

agcacagccg cactcctgtt gaccctggat cccacccttt gagcctgacc ccactgcagc     2100

ctctgcccag ccagccctgc gctcccccac cctgacagtg agctgtgtcc tcgtcccccc     2160

acccccttcc cagtcaaggt ggtggcctgg gccgctccac ctcaccggtg cagtgaccca     2220

ggacggcatc agcagcccag tgagcaccag gggtggcata gggcacccat gaggctgcgc     2280

tgcactcctc tgccctgggg ccacctcggc tgctgcagcc tgcccagcag cacattccag     2340

tcactgcccc cgcactccca cagggctcag gctgggctca gaggccactg agatgccagc     2400

tccttgagag cagtgggggt gtcccaggcc agagcagcct cttcctctcc tggtcccaga     2460

aaaacccttg cagtaaatgg tggcctctgg gtggtta                              2497


<210> 1762
<211> 809
<212> DNA
<213> Homo sapiens

<400> 1762
cgcccgccat ggccgagagc gactgggaca cggtgacggt gctgcgcaag aagggcccta       60

cggccgccca ggccaaatcc aagcaggcta tcttagcggc acagagacga ggagaagatg      120

tggagacttc caagaaatgg gctgctggcc agaacaaaca acattctatt accaagaaca      180

cggccaagct ggaccgggag acagaggagc tgcaccatga cagggtgacc ctggaggtgg      240

gcaaggtgat ccagcaaggt cggcagagca aggggcttac gcagaaggac ctggccacga      300

aaatcaatga gaagccacag gtgatcgcgg actatgagag cggacgggcc atacccaata      360

accaggtgct tggcaaaatc gagcgggcca ttggtgagtg tccctccacc cttcgccggg      420

tccgctgaac agggaggcta cccgctccca gctggggttg gtgagagtgg gactcggggg      480

aagaagatgg ccctgggggt cccctgttct ctgaattctg gagctttgct tctccaggta      540

gtacagactg agggatggtg gggtctctgc aggcctcagg aaacccctaa gagcaagtgg      600

agtccgagtc ccttcccctt gccagttccc gtcagcctgt gctgttggcg atggttctct      660

gagcctgagc acagcgggtc cgggccctgt cagcatgggg ccggaagcca gttccacaga      720

ggaccccggc tccggttctt ccggagaggg gtgttcatgc tctgctgtct aaggtgatca      780

gactcatcct cttcaaaatt agatgtggg                                        809


<210> 1763
<211> 790
<212> DNA
<213> Homo sapiens

<400> 1763
ccggacggac gctcgtcttc gcccgccatg gccgagagcg actgggacac ggtgacggtg       60

ctgcgcaaga agggccctac ggccgcccag gccaaatcca agcaggctat cttagcggca      120

cagagacgag gagaagatgt ggagacttcc aagaaatggg ctgctggcca gaacaaacaa      180

cattctatta ccaagaacac ggccaagctg gaccgggaga cagaggagct gcaccatgac      240

agggtgaccc tggaggtggg caaggtgatc cagcaaggtc ggcagagcaa ggggcttacg      300

cagaaggacc tggccacgaa aatcaatgag aagccacagg tgatcgcgga ctatgagagc      360

ggacgggcca tacccaataa ccaggtgctt ggcaaaatcg agcgggccat tgatgtggga      420

accaggagtg ctcgtgtgct gagagcccag tgaggcacgg gagcggcgtg gccccccttc      480

cctgggaaga tgttgaagag gggcagcgtt ggggggagga gggagctggt gctgcagtgg      540

ccagtggctg tggctcattt caggcctcaa gctccgggga aaggacattg gaaagcccat      600

cgagaagggg cctagggcga aatgaacaca aagcctcgaa atcagtgcgc tccagctgat      660

ctcgttccgc cggttcccct tggccgccag ttccgttctc ctcacgggcc gaacggaaca      720

aggggtccag cttgcggggg accctcccca gcccattcct gctgtcaaac aaacaaaacc      780

ttgcaaagcg                                                             790


<210> 1764
<211> 510
<212> DNA
<213> Homo sapiens

<400> 1764
cacaacgttc ccgtttgctt atagttgtca acgaccatga tctctggacc cacactacag       60

taacaagttt gtcagtcatt ttcagataag gtgcaaatca agggatggct ttgtccccac      120

ttcggcgcag gtgggacaga cttggggaag acgcagctga agagacaaat tctcaggaca      180

tgggaaagcg gaaccaccaa aaggagtgat gatcaacgat ctcatgataa atctggatgc      240

tagttctcat gcctcaggac atcctactgg gaacgacaca ccagctcctg ggatcagact      300

ttcatctact taggacccct ctttgcccag actactaaag ccagtcttca ctagccacga      360

atggctaccc aaaggaaaca cttggtgaaa gattttaatc cttacattac ctgctatatc      420

tgtaaagggt atctgatcaa gccaacaaca gtgacggaat gcctccatac atctgcagaa      480

tcctactgga tgtccacttg gatgtcctga                                       510


<210> 1765
<211> 1979
<212> DNA
<213> Homo sapiens

<400> 1765
acatattcag cagggttagc ttgtcctccc ctccctcttc agcttcccag acactgagtc       60

tggaatgaaa attcacctgc ctctgagttg gctcctaatg ggggtgggag tgttacttcg      120

gttcccaggt tggaagatta tctcacccgg ccccagctat ataagctgac cggtgtggag      180

gggcccagca gggccaactc cagggattcc ttccacgaca gaaaaacata caagactcct      240

tcagccaaca tgatggtact gaaagtagag gaactggtca ctggaaagaa gaatggcaat      300

ggggaggcag gggaattcct tcctgaggat ttcagagatg gagagtatga agctgctgtt      360

actttagaga agcaggagga tctgaagaca cttctagccc accctgtgac cctgggggag      420

caacagtgga aaagcgagaa acaacgagag gcagagctca aaaagaaaaa actagaacaa      480

agatcaaagc ttgaaaattt agaagacctt gaaataatca ttcaactgaa gaaaaggaaa      540

aaatacagga aaactaaagt tccagttgta aaggaaccag aacctgaaat cattacggaa      600

cctgtggatg tgcctacgtt tctgaaggct gctctggaga ataaactgcc agtagtagaa      660

aaattcttgt cagacaagaa caatccagat gtttgtgatg agtataaacg gacagctctt      720

catagagcat gcttggaagg acatttggca attgtggaga agttaatgga agctggagcc      780

cagatcgaat tccgtgatat gcttgaatcc acagccatcc actgggcaag ccgtggagga      840

aacctggatg ttttaaaatt gttgctgaat aaaggagcaa aaattagcgc ccgagataag      900

ttgctcagca cagcgctgca tgtggcggtg aggactggcc actatgagtg cgcggagcat      960

cttatcgcct gtgaggcaga cctcaacgcc aaagacagag aaggagatac cccgttgcat     1020

gatgcggtga gactgaaccg ctataagatg atccgactcc tgattatgta tggcgcggat     1080

ctcaacatca agaactgtgc tgggaagacg ccgatggatc tggtgctaca ctggcagaat     1140

ggaaccaaag caatattcga cagcctcaga gagaactcct acaagacctc tcgcatagct     1200

acattctgag gcaaacgaca gactcttaat cagtaaatgt tcactggcat tttgaaggca     1260

tggcccaaga gaagagacac tagccataaa atctagtttc tatttatcaa cgtgttgtga     1320

agatgtacct aatgaagttt tgagaaagca cagggttata ggtgtttaaa tttcctttag     1380

tgaaactctt atttattttt atgtattcct gtttatttat ttactgccac gctactgata     1440

ttcagacctt catgatcatc catctggtga gcagagcttc atttgtatat aacactttca     1500

gagccttccc acccataggt agttcttaaa ccaggtgaaa gagcaaagtt caagtgccta     1560

cttatgtgtc attcgctcat gtaagagttt ttaagagagg gctgattatc acagccctct     1620

tttctcctga atttttaatg cagaagtttg aatgaagcaa gggaaggcat gtagggacag     1680

gaaaggaaac aatggaagga aagtgattct gtgaaaagga cagtgaagcc agctatttta     1740

cccccaggct ggattttttt tttttttttt tttttttttt tttaccgagt acacagagta     1800

cccaagtgaa gagaacgtca tgagtgtaag tgcaaatcag tggaaggagc ggcaaactgg     1860

gacatgcaga attgaatttg ctcaaaaaag atgaaaggaa atgcaaactg taaatgtata     1920

aatgtatatt gtattgtatg tacattttat attcataata aaggcaatca aactctaaa      1979


<210> 1766
<211> 2129
<212> DNA
<213> Homo sapiens

<400> 1766
cggcccaagg cgttcaggca cgcgctttcg gtgctcggag cggaagcagc ggcgagaggc       60

tcggaggcgc gggggcggcc gagcggcggg cgacgggggc gggcgacggg ggcgggcgac      120

gcgggccgcg gcacgggcgg agccggggcc atggagccgc cgctgccggg ctaggcaggt      180

cgtgccccgc cgggccggcg gcgatgtcgg gctaccagcg ccgcccgggc gccaccccgc      240

tgtcccgagc ccggagcctc gccattcccg acgatgacag atttgaagat ctggaagagg      300

caaatccatt ctcttttaga gagtttctga agaccaagaa cctcggcctc tcgaaagagg      360

atccggccag cagaatttat gcaaaggaag cctcgaggca ttccctggga cttgaccaca      420

actccccacc ctcccaaacc ggcgggtatg gcctggagta tcagcagcca tttttcgagg      480

atccgacagg ggctggtgac ctcctggatg aggaggagga tgaggacacc ggatggagtg      540

gggcctacct gccgtccgcc atcgagcaga ctcaccccga gagggtccct gccggcacgt      600

cgccctgcag cacatacctt tcctttttct ccaccccgtc ggagctggca gggcctgagt      660

ctctgccctc gtgggcgttg agtgacactg attctcgcgt gtctccggcc tctccggcag      720

ggagtcctag cgcagacttt gcggttcatg gagagtctct gggagacagg cacctgcgga      780

cgctgcagat aagttacgac gcactgaaag atgaaaattc taagctgaga agaaagctga      840

atgaggttca gagcttctct gaagctcaaa cagaaatggt gaggacgctt gagcggaagt      900

tagaagcaaa aatgatcaag gaggaaagcg actaccacga cctggagtcg gtggttcagc      960

aggtggagca gaacctggag ctgatgacca aacgggctgt aaaggcagaa aaccacgtcg     1020

tgaaactaaa acaggaaatc agtttgctcc aggcgcaggt ctccaacttc cagcgagaga     1080

atgaagccct gcggtgcggc cagggtgcca gcctgaccgt ggtgaagcag aacgccgacg     1140

tggccctgca gaacctccgg gtggtcatga acagtgcaca ggcttccatc aagcaactgg     1200

tttccggagc tgagacactg aatcttgttg ccgaaatcct taaatctata gacagaattt     1260

ctgaagttaa agacgaggag gaagactctt gaggacccct gggtgttctc agcatgaagc     1320

tccgtgtata ccctgaggtc accaccgctc gatctaaatg tgcagttgtg tccttaaata     1380

tgcagtcttc acccagagta aagtgttgat cgcaagagtc cagtgtcgtg ccctcagcca     1440

gttcttggcc accacaatgg gagcagccct ggccgagttg tctctgtggt ttctatgcag     1500

cccttcttgg cgaaattcct gcgatcttat agattctaat gagctcttgg aagacattgt     1560

cataaaagcc agtgatttta agaaaaagag tggttctgga atcaatgttt tccagtccca     1620

tcccagaaca tcagttgtaa gataagtaca attggttgtc cttgatttca taagtagaac     1680

aaacactaaa tgtgcctctg agatggccac cccgggcagg gacctgtgcc ttccgccgat     1740

gctcagggct ccctctggct cccgggtcac tcttgtggcc ccagtgggtg gtccctgcag     1800

tcatggcctg agtgcgcagg ggccaccgcg tggctgctgc tgtcctcctc cgggacccac     1860

ggggaccaag gtcacacgtt ccgtgctgtg aagctgtcca gatgtgcctc tttggctggg     1920

ggttctggtg gacgtttcaa gtggcatttt gtacaatgca ggttagaatt caggaatttc     1980

aagtatgtgc ccgggtctgt caggtcccag ttgcctttct gacggccccc ctcagaggga     2040

cggcgatgag cactaaatgc ttttttgact attttcctat agattttttt taaaactttt     2100

ttttcctcct gttccaattg atagctttc                                       2129


<210> 1767
<211> 6419
<212> DNA
<213> Homo sapiens

<400> 1767
gaatttgaaa acggtaacat cgcagtgctg ctcgcgggtc tggctagtca ggcgaagttt       60

gcagaatgga atctaatttt aatcaagagg gagtacctcg accatcttat gtttttagtg      120

ctgacccaat tgcaaggcct tcagaaataa atttcgatgg cattaagctt gatctgtctc      180

atgaattttc cttagttgct ccaaatactg aggcaaacag tttcgaatct aaagattatc      240

tccaggtttg tcttcgaata agaccattta cacagtcaga aaaagaactt gagtctgagg      300

gctgtgtgca tattctggat tcacagactg ttgtgctgaa agagcctcaa tgcatccttg      360

gtcggttaag tgaaaaaagc tcagggcaga tggcacagaa attcagtttt tccaaggttt      420

ttggcccagc aactacacag aaggaattct ttcagggttg cattatgcaa ccagtaaaag      480

acctcttgaa aggacagagt cgtctgattt ttacttacgg gctaaccaat tcaggaaaaa      540

catatacatt tcaagggaca gaagaaaata ttggcattct gcctcgaact ttgaatgtat      600

tatttgatag tcttcaagaa agactgtata caaagatgaa ccttaaacca catagatcca      660

gagaatactt aaggttatca tcagaacaag agaaagaaga aattgctagc aaaagtgcat      720

tgcttcggca aattaaagag gttactgtgc ataatgatag tgatgatact ctttatggaa      780

gtttaactaa ctctttgaat atctcagagt ttgaagaatc cataaaagat tatgaacaag      840

ccaacttgaa tatggctaat agtataaaat tttctgtgtg ggtttctttc tttgaaattt      900

acaatgaata tatttatgac ttatttgttc ctgtatcatc taaattccaa aagagaaaga      960

tgctgcgcct ttcccaagac gtaaagggct attcttttat aaaagatcta caatggattc     1020

aagtatctga ttccaaagaa gcctatagac ttttaaaact aggaataaag caccagagtg     1080

ttgccttcac aaaattgaat aatgcttcca gtagaagtca cagcatattc actgttaaaa     1140

tattacagat tgaagattct gaaatgtctc gtgtaattcg agtcagtgaa ttatctttat     1200

gtgatcttgc tggttcagaa cgaactatga agacacagaa tgaaggtgaa aggttaagag     1260

agactgggaa tatcaacact tctttattga ctctgggaaa gtgtattaac gtcttgaaga     1320

atagtgaaaa gtcaaagttt caacagcatg tgcctttccg ggaaagtaaa ctgactcact     1380

attttcaaag tttttttaat ggtaaaggga aaatttgtat gattgtcaat atcagccaat     1440

gttatttagc ctatgatgaa acactcaatg tattgaagtt ctccgccatt gcacaaaaag     1500

tttgtgtccc agacacttta aattcctctc aagagaaatt atttggacct gtcaaatctt     1560

ctcaagatgt atcactagac agtaattcaa acagtaaaat attaaatgta aaaagagcca     1620

ccatttcatg ggaaaatagt ctagaagatt tgatggaaga cgaggatttg gttgaggagc     1680

tagaaaacgc tgaagaaact caaaatgtgg aaactaaact tcttgatgaa gatctagata     1740

aaacattaga ggaaaataag gctttcatta gccacgagga gaaaagaaaa ctgttggact     1800

taatagaaga cttgaaaaaa aaactgataa atgaaaaaaa ggaaaaatta accttggaat     1860

ttaaaattcg agaagaagtt acacaggagt ttactcagta ttgggctcaa cgggaagctg     1920

actttaagga gactctgctt caagaacgag agatattaga agaaaatgct gaacgtcgtt     1980

tggctatctt caaggatttg gttggtaaat gtgacactcg agaagaagca gcgaaagaca     2040

tttgtgccac aaaagttgaa actgaagaaa cacataatta tgtaggattt gaagatatta     2100

ttgattctct tcaagataat gttgctgata ttaagaaaca ggctgaaatt gctcacttat     2160

atattgcatc tcttcctgac ccccaggaag ctactgcttg tttagaacta aagtttaatc     2220

aaattaaagc tgaattagct aaaaccaaag gagaattaat caaaaccaaa gaagagttaa     2280

aaaagagaga aaatgaatca gattcattga ttcaagagct tgagacatct aataagaaaa     2340

taattacaca gaatcaaaga attaaagaat tgataaatat aattgatcaa aaagaagata     2400

ctatcaacga atttcagaac ctaaagtctc atatggaaaa cacatttaaa tgcaatgaca     2460

aggctgatac atcttcttta ataataaaca ataaattgat ttgtaatgaa acagttgaag     2520

tacctaagga cagcaaatct aaaatctgtt cagaaagaaa aagagtaaat gaaaatgaac     2580

ttcagcaaga tgaaccacca gcaaagaaag ggtctatcca tgttagttca gctatcactg     2640

aagaccaaaa gaaaagtgaa gaagtgcgac cgaacattgc agaaattgaa gacatcagag     2700

ttttacaaga aaataatgaa ggactgagag catttttact cactattgag aatgaactta     2760

aaaatgaaaa ggaagaaaaa gcagaattaa ataaacagat tgttcatttt cagcaggaac     2820

tttctctttc tgaaaaaaag aatttaactt taagtaaaga ggtccaacaa attcagtcaa     2880

attatgatat tgcaattgct gaattacatg tgcagaaaag taaaaatcaa gaacaggagg     2940

aaaagatcat gaaattgtca aatgagatag aaactgctac aagaagcatt acaaataatg     3000

tttcacaaat aaaattaatg cacacgaaaa tagacgaact acgtactctt gattcagttt     3060

ctcagatttc aaacatagat ttgctcaatc tcagggatct gtcaaatggt tctgaggagg     3120

ataatttgcc aaatacacag ttagaccttt taggtaatga ttatttggta agtaagcaag     3180

ttaaagaata tcgaattcaa gaacccaata gggaaaattc tttccactct agtattgaag     3240

ctatttggga agaatgtaaa gagattgtga aggcctcttc caaaaaaagt catcagattg     3300

aggaactgga acaacaaatt gaaaaattgc aggcagaagt aaaaggctat aaggatgaaa     3360

acaatagact aaaggagaag gagcataaaa accaagatga cctactaaaa gaaaaagaaa     3420

ctcttataca gcagctgaaa gaagaattgc aagaaaaaaa tgttactctt gatgttcaaa     3480

tacagcatgt agttgaagga aagagagcgc tttcagaact tacacaaggt gttacttgct     3540

ataaggcaaa aataaaggaa cttgaaacaa ttttagagac tcagaaagtt gaatgtagtc     3600

attcagccaa gttagaacaa gacattttgg aaaaggaatc tatcatctta aagctagaaa     3660

gaaatttgaa ggaatttcaa gaacatcttc aggattctgt caaaaacacc aaagatttaa     3720

atgtaaagga actcaagctg aaagaagaaa tcacacagtt aacaaataat ttgcaagata     3780

tgaaacattt acttcaatta aaagaagaag aagaagaaac caacaggcaa gaaacagaaa     3840

aattgaaaga ggaactctct gcaagctctg ctcgtaccca gaatctgaaa gcagatcttc     3900

agaggaagga agaagattat gctgacctga aagagaaact gactgatgcc aaaaagcaga     3960

ttaagcaagt acagaaagag gtatctgtaa tgcgtgatga ggataaatta ctgaggatta     4020

aaattaatga actggagaaa aagaaaaacc agtgttctca ggaattagat atgaaacagc     4080

gaaccattca gcaactcaag gagcagttaa ataatcagaa agtggaagaa gctatacaac     4140

agtatgagag agcatgcaaa gatctaaatg ttaaagagaa aataattgaa gacatgcgaa     4200

tgacactaga agaacaggaa caaactcagg tagaacagga tcaagtgctt gaggctaaat     4260

tagaggaagt tgaaaggctg gccacagaat tggaaaaatg gaaggaaaaa tgcaatgatt     4320

tggaaaccaa aaacaatcaa aggtcaaata aagaacatga gaacaacaca gatgtgcttg     4380

gaaagctcac taatcttcaa gatgagttac aggagtctga acagaaatat aatgctgata     4440

gaaagaaatg gttagaagaa aaaatgatgc ttatcactca agcgaaagaa gcagagaata     4500

tacgaaataa agagatgaaa aaatatgctg aggacaggga gcgttttttt aagcaacaga     4560

atgaaatgga aatactgaca gcccagctga cagagaaaga tagtgacctt caaaagtggc     4620

gagaagaacg agatcaactg gttgcagctt tagaaataca gctaaaagca ctgatatcca     4680

gtaatgtaca gaaagataat gaaattgaac aactaaaaag gatcatatca gagacttcta     4740

aaatagaaac acaaatcatg gatatcaagc ccaaacgtat tagttcagca gatcctgaca     4800

aacttcaaac tgaacctcta tcgacaagtt ttgaaatttc cagaaataaa atagaggatg     4860

gatctgtagt ccttgactct tgtgaagtgt caacagaaaa tgatcaaagc actcgatttc     4920

caaaacctga gttagagatt caatttacac ctttacagcc aaacaaaatg gcagtgaaac     4980

accctggttg taccacacca gtgacagtta agattcccaa ggctcggaag aggaagagta     5040

atgaaatgga ggaggacttg gtgaaatgtg aaaataagaa gaatgctaca cccagaacta     5100

atttgaaatt tcctatttca gatgatagaa attcttctgt caaaaaggaa caaaaggttg     5160

ccatacgtcc atcatctaag aaaacatatt ctttacggag tcaggcatcc ataattggtg     5220

taaacctggc cactaagaaa aaagaaggaa cactacagaa atttggagac ttcttacaac     5280

attctccctc aattcttcaa tcaaaagcaa agaagataat tgaaacaatg agctcttcaa     5340

agctctcaaa tgtagaagca agtaaagaaa atgtgtctca accaaaacga gccaaacgga     5400

aattatacac aagtgaaatt tcatctccta ttgatatatc aggccaagtg attttaatgg     5460

accagaaaat gaaggagagt gatcaccaga ttatcaaacg acgacttcga acaaaaacag     5520

ccaaataaat cacttatgga aatgtttaat ataaatttta tagtcatagt cattggaact     5580

tgcatcctgt attgtaaata taaatgtata tattatgcat taaatcactc tgcatataga     5640

ttgctgtttt atacatagta taattttaat tcaataaatg agtcaaaatt tgtatatttt     5700

tataaggctt ttttataata gcttctttca aactgtattt ccctattatc tcagacattg     5760

gatcagtgaa gatcctagga aagaggctgt tattctcatt tattttgcta tacaggatgt     5820

aataggtcag gtatttggtt tacttatatt taacaatgtc ttatgaattt tttttacttt     5880

atctgttata caactgattt tacatatctg tttggattat agctaggatt tggagaataa     5940

gtgtgtacag atcacaaaac atgtatatac attatttaga aaagatctca agtctttaat     6000

tagaatgtct cacttatttt gtaaacattt tgtgggtaca tagtacatgt atatatttac     6060

ggggtatgtg agatgttttg acacaggcat gcaatgtgaa atacgtgtat catggagaat     6120

gaggtatcca tcccctcaag catttttcct ttgaattaca gataatccaa ttacattctt     6180

tagatcattt aaaaatatac aagtaagtta ttattgatta tagtcactct attgtgctat     6240

cagatagtag atcattcttt ttatcttatt tgtttttgta cccattaacc atccccacct     6300

ccccctgcaa ccgtcagtac ccttaccagc cactggtaac cattcttcta ctctgtatgc     6360

ccatgaggtc aattgatttt atttttagat cccataaata aatgagaaca tgcagtctt      6419


<210> 1768
<211> 3130
<212> DNA
<213> Homo sapiens

<400> 1768
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc agaaagcata acccctactg tagaactaaa tgcactgtgc atgaaacttg      300

gaaaaaaacc aatgtataag cctgttgacc cttactctcg gatgcagtcc acctataact      360

acaacatgag aggaggtgct tatcccccga ggtactttta cccatttcca gttccacctt      420

tactttatca agtggaactt tctgtgggag gacagcaatt taatggcaaa ggaaagacaa      480

gacaggctgc gaaacacgat gctgctgcca aagcgttgag gatcctgcag aatgagcccc      540

tgccagagag gctggaggtg aatggaagag aatccgaaga agaaaatctc aataaatctg      600

aaataagtca agtgtttgag attgcactta aacggaactt gcctgtgaat ttcgaggtgg      660

cccgggagag tggcccaccc cacatgaaga actttgtgac caaggtttcg gttggggagt      720

ttgtggggga aggtgaaggg aaaagcaaga agatttcaaa gaaaaatgcc gccatagctg      780

ttcttgagga gctgaagaag ttaccgcccc tgcctgcagt tgaacgagta aagcctagaa      840

tcaaaaagaa aacaaaaccc atagtcaaga caagcccaga atatggccag gggatcaatc      900

cgattagccg actggcccag atccagcagg caaaaaagga gaaggagcca gagtacacgc      960

tcctcacaga gcgaggcctc ccgcgccgca gggagtttgt gatgcaggtg aaggttggaa     1020

accacactgc agaaggaacg ggcaccaaca agaaggtggc caagcgcaat gcagccgaga     1080

acatgctgga gatccttggt ttcaaagtcc cgcaggcgca gcccaccaaa cccgcactca     1140

agtcagagga gaagacaccc ataaagaaac caggggatgg aagaaaagta accttttttg     1200

aacctggctc tggggatgaa aatgggacta gtaataaaga ggatgagttc aggatgcctt     1260

atctaagtca tcagcagctg cctgctggaa ttcttcccat ggtgcccgag gtcgcccagg     1320

ctgtaggagt tagtcaagga catcacacca aagattttac cagggcagct ccgaatcctg     1380

ccaaggccac ggtaactgcc atgatagccc gagagttgtt gtatgggggc acctcgccca     1440

cagccgagac cattttaaag aataacatct cttcaggcca cgtaccccat ggacctctca     1500

cgagaccctc tgagcaactg gactatcttt ccagagtcca gggattccag gttgaataca     1560

aagacttccc caaaaacaac aagaacgaat ttgtatctct tatcaattgc tcctctcagc     1620

cacctctgat cagccatggt atcggcaagg atgtggagtc ctgccatgat atggctgcgc     1680

tgaacatctt aaagttgctg tctgagttgg accaacaaag tacagagatg ccaagaacag     1740

gaaacggacc aatgtctgtg tgtgggaggt gctgaacctt ttctggccat gaaccattat     1800

aaaatcccaa catatatact gaaaatactg aaactgcttt gaaaatttgg aatttctgat     1860

acctccagtg ggccgagaga cacggtgggt aaaggatgtg ggcagcagca gggaagacaa     1920

cagaaacaca aggaggcggc tgtggccggg ctggactgtg ctggggtttg ttgtgatggc     1980

cactcggtga cctggcggtc cctacgcaat agcagctgcc tgtggggaag aagggctgcc     2040

cagccagctg gttctcccgg gacaccagca gatccacacc ctgggcacct ccgtgtttgg     2100

tctttttttt cccctgtgtg aaagaagaaa cggcacgacc ccttctcaag ctggctcact     2160

cagacacatt gggacaaacc ctggacagcc atgccagaga gaggcctttg accggcccca     2220

gagctaaaag caccagagaa aatcaaatgc ttcctactca gcgtgaccca acttttctag     2280

tgtgccacgg ccccaccacc tcctgcagta cccacaccat caccactgct ttctcttcca     2340

acagtgatct gtattcttag tttcattatt ttcttttgat tgatatgaca ctatataaaa     2400

ttttcatttg agaatttctc aattgtatct agttaaatag cacagtttgg aaacttgtct     2460

gagactgact ttatcaataa tctaaccgac aaagatcata tccatgtgta tgtggttaga     2520

catttttatt tcattgacta acccaggaca gtttcagtga tgcaaattgt gtgccctctg     2580

gttcagctga aacagtcctg gactttcaaa aaccttgaat aagtctccca cagttgtata     2640

aattggacaa tttaggaatt ttaaacttta gatgatcatt tggttccatt tttatttcat     2700

ttttattttt gttaatgcaa acaggactta aatgaacttt gatctctgtt ttaaagatta     2760

ttaaaaaaca ttgtgtatct atacatatgg ctcttgagga cttagctttc actacactac     2820

aggatatgat ctccatgtag tccatataaa cctgcagagt gattttccag agtgctcgat     2880

actgttaatt acatctccat tagggctgaa aagaatgacc tacgtttctg tatacagctg     2940

tgttgctttt gatgttgtgt tactgtacac agaagtgtgt gcactgaggc tctgcgtgtg     3000

gtccgtatgg aaagcctggt agccctgcga gttaagtact gcttccattc attgtttacg     3060

ctggaatttt tctccccatg gaatgtaagt aaaacttaag tgtttgtcat caataaatgg     3120

taatactaaa                                                            3130


<210> 1769
<211> 3154
<212> DNA
<213> Homo sapiens

<400> 1769
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc agaaagcata acccctactg tagaactaaa tgcactgtgc atgaaacttg      300

gaaaaaaacc aatgtataag cctgttgacc cttactctcg gatgcagtcc acctataact      360

acaacatgag aggaggtgct tatcccccga ggtactttta cccatttcca gttccacctt      420

tactttatca agtggaactt tctgtgggag gacagcaatt taatggcaaa ggaaagacaa      480

gacaggctgc gaaacacgat gctgctgcca aagcgttgag gatcctgcag aatgagcccc      540

tgccagagag gctggaggtg aatggaagag aatccgaaga agaaaatctc aataaatctg      600

aaataagtca agtgtttgag attgcactta aacggaactt gcctgtgaat ttcgagtctt      660

tccctctgaa acaggtggcc cgggagagtg gcccacccca catgaagaac tttgtgacca      720

aggtttcggt tggggagttt gtgggggaag gtgaagggaa aagcaagaag atttcaaaga      780

aaaatgccgc catagctgtt cttgaggagc tgaagaagtt accgcccctg cctgcagttg      840

aacgagtaaa gcctagaatc aaaaagaaaa caaaacccat agtcaagcca cagacaagcc      900

cagaatatgg ccaggggatc aatccgatta gccgactggc ccagatccag caggcaaaaa      960

aggagaagga gccagagtac acgctcctca cagagcgagg cctcccgcgc cgcagggagt     1020

ttgtgatgca ggtgaaggtt ggaaaccaca ctgcagaagg aacgggcacc aacaagaagg     1080

tggccaagcg caatgcagcc gagaacatgc tggagatcct tggtttcaaa gtcccgcagg     1140

cgcagcccac caaacccgca ctcaagtcag aggagaagac acccataaag aaaccagggg     1200

atggaagaaa agtaaccttt tttgaacctg gctctgggga tgaaaatggg actagtaata     1260

aagaggatga gttcaggatg ccttatctaa gtcatcagca gctgcctgct ggaattcttc     1320

ccatggtgcc cgaggtcgcc caggctgtag gagttagtca aggacatcac accaaagatt     1380

ttaccagggc agctccgaat cctgccaagg ccacggtaac tgccatgata gcccgagagt     1440

tgttgtatgg gggcacctcg cccacagccg agaccatttt aaagaataac atctcttcag     1500

gccacgtacc ccatggacct ctcacgagac cctctgagca actggactat ctttccagag     1560

tccagggatt ccaggttgaa tacaaagact tccccaaaaa caacaagaac gaatttgtat     1620

ctcttatcaa ttgctcctct cagccacctc tgatcagcca tggtatcggc aaggatgtgg     1680

agtcctgcca tgatatggct gcgctgaaca tcttaaagtt gctgtctgag ttggaccaac     1740

aaagtacaga gatgccaaga acaggaaacg gaccaatgtc tgtgtgtggg aggtgctgaa     1800

ccttttctgg ccatgaacca ttataaaatc ccaacatata tactgaaaat actgaaactg     1860

ctttgaaaat ttggaatttc tgatacctcc agtgggccga gagacacggt gggtaaagga     1920

tgtgggcagc agcagggaag acaacagaaa cacaaggagg cggctgtggc cgggctggac     1980

tgtgctgggg tttgttgtga tggccactcg gtgacctggc ggtccctacg caatagcagc     2040

tgcctgtggg gaagaagggc tgcccagcca gctggttctc ccgggacacc agcagatcca     2100

caccctgggc acctccgtgt ttggtctttt ttttcccctg tgtgaaagaa gaaacggcac     2160

gaccccttct caagctggct cactcagaca cattgggaca aaccctggac agccatgcca     2220

gagagaggcc tttgaccggc cccagagcta aaagcaccag agaaaatcaa atgcttccta     2280

ctcagcgtga cccaactttt ctagtgtgcc acggccccac cacctcctgc agtacccaca     2340

ccatcaccac tgctttctct tccaacagtg atctgtattc ttagtttcat tattttcttt     2400

tgattgatat gacactatat aaaattttca tttgagaatt tctcaattgt atctagttaa     2460

atagcacagt ttggaaactt gtctgagact gactttatca ataatctaac cgacaaagat     2520

catatccatg tgtatgtggt tagacatttt tatttcattg actaacccag gacagtttca     2580

gtgatgcaaa ttgtgtgccc tctggttcag ctgaaacagt cctggacttt caaaaacctt     2640

gaataagtct cccacagttg tataaattgg acaatttagg aattttaaac tttagatgat     2700

catttggttc catttttatt tcatttttat ttttgttaat gcaaacagga cttaaatgaa     2760

ctttgatctc tgttttaaag attattaaaa aacattgtgt atctatacat atggctcttg     2820

aggacttagc tttcactaca ctacaggata tgatctccat gtagtccata taaacctgca     2880

gagtgatttt ccagagtgct cgatactgtt aattacatct ccattagggc tgaaaagaat     2940

gacctacgtt tctgtataca gctgtgttgc ttttgatgtt gtgttactgt acacagaagt     3000

gtgtgcactg aggctctgcg tgtggtccgt atggaaagcc tggtagccct gcgagttaag     3060

tactgcttcc attcattgtt tacgctggaa tttttctccc catggaatgt aagtaaaact     3120

taagtgtttg tcatcaataa atggtaatac taaa                                 3154


<210> 1770
<211> 3332
<212> DNA
<213> Homo sapiens

<400> 1770
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc agacggagtc tcgctctttt gccaggctgg agtgcagtgg cgcgatcctg      300

agtcactgca acctccacct cccaggttca agcgattctc ctgcttcagc ctgccaagta      360

gctgggacta cagagtttat taaccactta acctctcaga actgaacaaa gacaacattg      420

ttcctggaac gccctctttt taaaaaagaa agcataaccc ctactgtaga actaaatgca      480

ctgtgcatga aacttggaaa aaaaccaatg tataagcctg ttgaccctta ctctcggatg      540

cagtccacct ataactacaa catgagagga ggtgcttatc ccccgaggta cttttaccca      600

tttccagttc cacctttact ttatcaagtg gaactttctg tgggaggaca gcaatttaat      660

ggcaaaggaa agacaagaca ggctgcgaaa cacgatgctg ctgccaaagc gttgaggatc      720

ctgcagaatg agcccctgcc agagaggctg gaggtgaatg gaagagaatc cgaagaagaa      780

aatctcaata aatctgaaat aagtcaagtg tttgagattg cacttaaacg gaacttgcct      840

gtgaatttcg aggtggcccg ggagagtggc ccaccccaca tgaagaactt tgtgaccaag      900

gtttcggttg gggagtttgt gggggaaggt gaagggaaaa gcaagaagat ttcaaagaaa      960

aatgccgcca tagctgttct tgaggagctg aagaagttac cgcccctgcc tgcagttgaa     1020

cgagtaaagc ctagaatcaa aaagaaaaca aaacccatag tcaagccaca gacaagccca     1080

gaatatggcc aggggatcaa tccgattagc cgactggccc agatccagca ggcaaaaaag     1140

gagaaggagc cagagtacac gctcctcaca gagcgaggcc tcccgcgccg cagggagttt     1200

gtgatgcagg tgaaggttgg aaaccacact gcagaaggaa cgggcaccaa caagaaggtg     1260

gccaagcgca atgcagccga gaacatgctg gagatccttg gtttcaaagt cccgcaggcg     1320

cagcccacca aacccgcact caagtcagag gagaagacac ccataaagaa accaggggat     1380

ggaagaaaag taaccttttt tgaacctggc tctggggatg aaaatgggac tagtaataaa     1440

gaggatgagt tcaggatgcc ttatctaagt catcagcagc tgcctgctgg aattcttccc     1500

atggtgcccg aggtcgccca ggctgtagga gttagtcaag gacatcacac caaagatttt     1560

accagggcag ctccgaatcc tgccaaggcc acggtaactg ccatgatagc ccgagagttg     1620

ttgtatgggg gcacctcgcc cacagccgag accattttaa agaataacat ctcttcaggc     1680

cacgtacccc atggacctct cacgagaccc tctgagcaac tggactatct ttccagagtc     1740

cagggattcc aggttgaata caaagacttc cccaaaaaca acaagaacga atttgtatct     1800

cttatcaatt gctcctctca gccacctctg atcagccatg gtatcggcaa ggatgtggag     1860

tcctgccatg atatggctgc gctgaacatc ttaaagttgc tgtctgagtt ggaccaacaa     1920

agtacagaga tgccaagaac aggaaacgga ccaatgtctg tgtgtgggag gtgctgaacc     1980

ttttctggcc atgaaccatt ataaaatccc aacatatata ctgaaaatac tgaaactgct     2040

ttgaaaattt ggaatttctg atacctccag tgggccgaga gacacggtgg gtaaaggatg     2100

tgggcagcag cagggaagac aacagaaaca caaggaggcg gctgtggccg ggctggactg     2160

tgctggggtt tgttgtgatg gccactcggt gacctggcgg tccctacgca atagcagctg     2220

cctgtgggga agaagggctg cccagccagc tggttctccc gggacaccag cagatccaca     2280

ccctgggcac ctccgtgttt ggtctttttt ttcccctgtg tgaaagaaga aacggcacga     2340

ccccttctca agctggctca ctcagacaca ttgggacaaa ccctggacag ccatgccaga     2400

gagaggcctt tgaccggccc cagagctaaa agcaccagag aaaatcaaat gcttcctact     2460

cagcgtgacc caacttttct agtgtgccac ggccccacca cctcctgcag tacccacacc     2520

atcaccactg ctttctcttc caacagtgat ctgtattctt agtttcatta ttttcttttg     2580

attgatatga cactatataa aattttcatt tgagaatttc tcaattgtat ctagttaaat     2640

agcacagttt ggaaacttgt ctgagactga ctttatcaat aatctaaccg acaaagatca     2700

tatccatgtg tatgtggtta gacattttta tttcattgac taacccagga cagtttcagt     2760

gatgcaaatt gtgtgccctc tggttcagct gaaacagtcc tggactttca aaaaccttga     2820

ataagtctcc cacagttgta taaattggac aatttaggaa ttttaaactt tagatgatca     2880

tttggttcca tttttatttc atttttattt ttgttaatgc aaacaggact taaatgaact     2940

ttgatctctg ttttaaagat tattaaaaaa cattgtgtat ctatacatat ggctcttgag     3000

gacttagctt tcactacact acaggatatg atctccatgt agtccatata aacctgcaga     3060

gtgattttcc agagtgctcg atactgttaa ttacatctcc attagggctg aaaagaatga     3120

cctacgtttc tgtatacagc tgtgttgctt ttgatgttgt gttactgtac acagaagtgt     3180

gtgcactgag gctctgcgtg tggtccgtat ggaaagcctg gtagccctgc gagttaagta     3240

ctgcttccat tcattgttta cgctggaatt tttctcccca tggaatgtaa gtaaaactta     3300

agtgtttgtc atcaataaat ggtaatacta aa                                   3332


<210> 1771
<211> 2455
<212> DNA
<213> Homo sapiens

<400> 1771
tttcctttcc cctttcataa aagcacagac ctaacagcac cctgggtgga aacctcttca       60

gcatttgctt ggaatcagta agctaaaaac aaaatcaacc gggaccccag cttttcagaa      120

ctgcagggaa acagccatca tgagtgaggt caccaagaat tccctggaga aaatccttcc      180

acagctgaaa tgccatttca cctggaactt attcaaggaa gacagtgtct caagggatct      240

agaagataga gtgtgtaacc agattgaatt tttaaacact gagttcaaag ctacaatgta      300

caacttgttg gcctacataa aacacctaga tggtaacaac gaggcagccc tggaatgctt      360

acggcaagct gaagagttaa tccagcaaga acatgctgac caagcagaaa tcagaagtct      420

agtcacttgg ggaaactacg cctgggtcta ctatcacttg ggcagactct cagatgctca      480

gatttatgta gataaggtga aacaaacctg caagaaattt tcaaatccat acagtattga      540

gtattctgaa cttgactgtg aggaagggtg gacacaactg aagtgtggaa gaaatgaaag      600

ggcgaaggtg tgttttgaga aggctctgga agaaaagccc aacaacccag aattctcctc      660

tggactggca attgcgatgt accatctgga taatcaccca gagaaacagt tctctactga      720

tgttttgaag caggccattg agctgagtcc tgataaccaa tacgtcaagg ttctcttggg      780

cctgaaactg cagaagatga ataaagaagc tgaaggagag cagtttgttg aagaagcctt      840

ggaaaagtct ccttgccaaa cagatgtcct ccgcagtgca gccaaatttt acagaagaaa      900

aggtgaccta gacaaagcta ttgaactgtt tcaacgggtg ttggaatcca caccaaacaa      960

tggctacctc tatcaccaga ttgggtgctg ctacaaggca aaagtaagac aaatgcagaa     1020

tacaggagaa tctgaagcta gtggaaataa agagatgatt gaagcactaa agcaatatgc     1080

tatggactat tcgaataaag ctcttgagaa gggactgaat cctctgaatg catactccga     1140

tctcgctgag ttcctggaga cggaatgtta tcagacacca ttcaataagg aagtccctga     1200

tgctgaaaag caacaatccc atcagcgcta ctgcaacctt cagaaatata atgggaagtc     1260

tgaagacact gctgtgcaac atggtttaga gggtttgtcc ataagcaaaa aatcaactga     1320

caaggaagag atcaaagacc aaccacagaa tgtatctgaa aatctgcttc cacaaaatgc     1380

accaaattat tggtatcttc aaggattaat tcataagcag aatggagatc tgctgcaagc     1440

agccaaatgt tatgagaagg aactgggccg cctgctaagg gatgcccctt caggcatagg     1500

cagtattttc ctgtcagcat ctgagcttga ggatggtagt gaggaaatgg gccagggcgc     1560

agtcagctcc agtcccagag agctcctctc taactcagag caactgaact gagacagagg     1620

aggaaaacag agcatcagaa gcctgcagtg gtggttgtga cgggtaggac gataggaaga     1680

cagggggccc caacctggga ttgctgagca gggaagcttt gcatgttgct ctaaggtaca     1740

tttttaaaga gttgtttttt ggccgggcgc agtggctcat gcctgtaatc ccagcacttt     1800

gggaggccga ggtgggcgga tcacgaggtc tggagtttga gaccatcctg gctaacacag     1860

tgaaatcccg tctctactaa aaatacaaaa aattagccag gcgtggtggc tggcacctgt     1920

agtcccagct acttgggagg ctgaggcagg agaatggcgt gaacctggaa ggaagaggtt     1980

gcagtgagcc aagattgcgc ccctgcactc cagcctgggc aacagagcaa gactccatct     2040

caaaaaaaaa aaaaaaaaaa aaaaagagtt gttttctcat gttcattata gttcattaca     2100

gttacatagt ccgaaggtct tacaactaat cactggtagc aataaatgct tcaggcccac     2160

atgatgctga ttagttctca gttttcattc agttcacaat ataaccacca ttcctgccct     2220

ccctgccaag ggtcataaat ggtgactgcc taacaacaaa atttgcagtc tcatctcatt     2280

ttcatccaga cttctggaac tcaaagatta acttttgact aaccctggaa tatctcttat     2340

ctcacttata gcttcaggca tgtatttata tgtattcttg atagcaatac cataatcaat     2400

gtgtattcct gatagtaatg ctacaataaa tccaaacatt tcaactctgt tagaa          2455


<210> 1772
<211> 2496
<212> DNA
<213> Homo sapiens

<400> 1772
cttccttccc ctaaaagcaa ttactcaaaa acggagaaaa catcagctga tgcgtgccct       60

actctcccac ccctttatat agttccttca gtatttactt gaggcagaca ggaagacttc      120

tgaagaacaa atcagcctgg tcaccagctt ttcggaacag cagagacaca gagggcagtc      180

atgagtgagg tcaccaagaa ttccctggag aaaatccttc cacagctgaa atgccatttc      240

acctggaact tattcaagga agacagtgtc tcaagggatc tagaagatag agtgtgtaac      300

cagattgaat ttttaaacac tgagttcaaa gctacaatgt acaacttgtt ggcctacata      360

aaacacctag atggtaacaa cgaggcagcc ctggaatgct tacggcaagc tgaagagtta      420

atccagcaag aacatgctga ccaagcagaa atcagaagtc tagtcacttg gggaaactac      480

gcctgggtct actatcactt gggcagactc tcagatgctc agatttatgt agataaggtg      540

aaacaaacct gcaagaaatt ttcaaatcca tacagtattg agtattctga acttgactgt      600

gaggaagggt ggacacaact gaagtgtgga agaaatgaaa gggcgaaggt gtgttttgag      660

aaggctctgg aagaaaagcc caacaaccca gaattctcct ctggactggc aattgcgatg      720

taccatctgg ataatcaccc agagaaacag ttctctactg atgttttgaa gcaggccatt      780

gagctgagtc ctgataacca atacgtcaag gttctcttgg gcctgaaact gcagaagatg      840

aataaagaag ctgaaggaga gcagtttgtt gaagaagcct tggaaaagtc tccttgccaa      900

acagatgtcc tccgcagtgc agccaaattt tacagaagaa aaggtgacct agacaaagct      960

attgaactgt ttcaacgggt gttggaatcc acaccaaaca atggctacct ctatcaccag     1020

attgggtgct gctacaaggc aaaagtaaga caaatgcaga atacaggaga atctgaagct     1080

agtggaaata aagagatgat tgaagcacta aagcaatatg ctatggacta ttcgaataaa     1140

gctcttgaga agggactgaa tcctctgaat gcatactccg atctcgctga gttcctggag     1200

acggaatgtt atcagacacc attcaataag gaagtccctg atgctgaaaa gcaacaatcc     1260

catcagcgct actgcaacct tcagaaatat aatgggaagt ctgaagacac tgctgtgcaa     1320

catggtttag agggtttgtc cataagcaaa aaatcaactg acaaggaaga gatcaaagac     1380

caaccacaga atgtatctga aaatctgctt ccacaaaatg caccaaatta ttggtatctt     1440

caaggattaa ttcataagca gaatggagat ctgctgcaag cagccaaatg ttatgagaag     1500

gaactgggcc gcctgctaag ggatgcccct tcaggcatag gcagtatttt cctgtcagca     1560

tctgagcttg aggatggtag tgaggaaatg ggccagggcg cagtcagctc cagtcccaga     1620

gagctcctct ctaactcaga gcaactgaac tgagacagag gaggaaaaca gagcatcaga     1680

agcctgcagt ggtggttgtg acgggtagga cgataggaag acagggggcc ccaacctggg     1740

attgctgagc agggaagctt tgcatgttgc tctaaggtac atttttaaag agttgttttt     1800

tggccgggcg cagtggctca tgcctgtaat cccagcactt tgggaggccg aggtgggcgg     1860

atcacgaggt ctggagtttg agaccatcct ggctaacaca gtgaaatccc gtctctacta     1920

aaaatacaaa aaattagcca ggcgtggtgg ctggcacctg tagtcccagc tacttgggag     1980

gctgaggcag gagaatggcg tgaacctgga aggaagaggt tgcagtgagc caagattgcg     2040

cccctgcact ccagcctggg caacagagca agactccatc tcaaaaaaaa aaaaaaaaaa     2100

aaaaaagagt tgttttctca tgttcattat agttcattac agttacatag tccgaaggtc     2160

ttacaactaa tcactggtag caataaatgc ttcaggccca catgatgctg attagttctc     2220

agttttcatt cagttcacaa tataaccacc attcctgccc tccctgccaa gggtcataaa     2280

tggtgactgc ctaacaacaa aatttgcagt ctcatctcat tttcatccag acttctggaa     2340

ctcaaagatt aacttttgac taaccctgga atatctctta tctcacttat agcttcaggc     2400

atgtatttat atgtattctt gatagcaata ccataatcaa tgtgtattcc tgatagtaat     2460

gctacaataa atccaaacat ttcaactctg ttagaa                               2496


<210> 1773
<211> 3534
<212> DNA
<213> Homo sapiens

<400> 1773
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc aggtggagtt ttgctcttgt cgcccaggct ggagtgcagt ggcgtgatct      300

cggctcactg caacctccac ctcccaggtt caagcgattt tcccacttca gcctcccgat      360

aagctgagat tacagagttt attaaccact taacctctca gaactgaaca aagacaacat      420

tgttcctgga acgccctctt tttaaaaaag aaagcataac ccctactgta gaactaaatg      480

cactgtgcat gaaacttgga aaaaaaccaa tgtataagcc tgttgaccct tactctcgga      540

tgcagtccac ctataactac aacatgagag gaggtgctta tcccccgagg tacttttacc      600

catttccagt tccaccttta ctttatcaag tggaactttc tgtgggagga cagcaattta      660

atggcaaagg aaagacaaga caggctgcga aacacgatgc tgctgccaaa gcgttgagga      720

tcctgcagaa tgagcccctg ccagagaggc tggaggtgaa tggaagagaa tccgaagaag      780

aaaatctcaa taaatctgaa ataagtcaag tgtttgagat tgcacttaaa cggaacttgc      840

ctgtgaattt cgagtctttc cctctgaaac aggtggcccg ggagagtggc ccaccccaca      900

tgaagaactt tgtgaccaag gtttcggttg gggagtttgt gggggaaggt gaagggaaaa      960

gcaagaagat ttcaaagaaa aatgccgcca tagctgttct tgaggagctg aagaagttac     1020

cgcccctgcc tgcagttgaa cgagtaaagc ctagaatcaa aaagaaaaca aaacccatag     1080

tcaagccaca gacaagccca gaatatggcc aggggatcaa tccgattagc cgactggccc     1140

agatccagca ggcaaaaaag gagaaggagc cagagtacac gctcctcaca gagcgaggcc     1200

tcccgcgccg cagggagttt gtgatgcagg tgaaggttgg aaaccacact gcagaaggaa     1260

cgggcaccaa caagaaggtg gccaagcgca atgcagccga gaacatgctg gagatccttg     1320

gtttcaaagt cccgcaggcg cagcccacca aacccgcact caagtcagag gagaagacac     1380

ccataaagaa accaggggat ggaagaaaag taaccttttt tgaacctggc tctggggatg     1440

aaaatgggac tagtaataaa gaggatgagt tcaggatgcc ttatctaagt catcagcagc     1500

tgcctgctgg aattcttccc atggtgcccg aggtcgccca ggctgtagga gttagtcaag     1560

gacatcacac caaagatttt accagggcag ctccgaatcc tgccaaggcc acggtaactg     1620

ccatgatagc ccgagagttg ttgtatgggg gcacctcgcc cacagccgag accattttaa     1680

agaataacat ctcttcaggc cacgtacccc atggacctct cacgagaccc tctgagcaac     1740

tggactatct ttccagagtc cagggattcc aggttgaata caaagacttc cccaaaaaca     1800

acaagaacga atttgtatct cttatcaatt gctcctctca gccacctctg atcagccatg     1860

gtatcggcaa ggatgtggag tcctgccatg atatggctgc gctgaacatc ttaaagttgc     1920

tgtctgagtt ggaccaacaa agtacagaga tgccaagaac aggaaacgga ccaatgtctg     1980

tgtgtgggag gtgctgaacc ttttctggcc atgaaccatt ataaaatccc aacatatata     2040

ctgaaaatac tgaaactgct ttgaaaattt ggaatttctg atacctccag tgggccgaga     2100

gacacggtgg gtaaaggatg tgggcagcag cagggaagac aacagaaaca caaggaggcg     2160

gctgtggccg ggctggactg tgctggggtt tgttgtgatg gccactcggt gacctggcgg     2220

tccctacgca atagcagctg cctgtgggga agaagggctg cccagccagc tggttctccc     2280

gggacaccag cagatccaca ccctgggcac ctccgtgttt ggtctttttt ttcccctgtg     2340

tgaaagaaga aacggcacga ccccttctca agctggctca ctcagacaca ttgggacaaa     2400

ccctggacag ccatgccaga gagaggcctt tgaccggccc cagagctaaa agcaccagag     2460

aaaatcaaat gcttcctact cagcgtgacc caacttttct agtgtgccac ggccccacca     2520

cctcctgcag tacccacacc atcaccactg ctttctcttc caacagtgat ctgtattctt     2580

agtttcatta ttttcttttg attgatatga cactatataa aattttcatt tgagaatttc     2640

tcaattgtat ctagttaaat agcacagttt ggaaacttgt ctgagactga ctttatcaat     2700

aatctaaccg acaaagatca tatccatgtg tatgtggtta gacattttta tttcattgac     2760

taacccagga cagtttcagt gatgcaaatt gtgtgccctc tggttcagct gaaacagtcc     2820

tggactttca aaaaccttga ataagtctcc cacagttgta taaattggac aatttaggaa     2880

ttttaaactt tagatgatca tttggttcca tttttatttc atttttattt ttgttaatgc     2940

aaacaggact taaatgaact ttgatctctg ttttaaagat tattaaaaaa cattgtgtat     3000

ctatacatat ggctcttgag gacttagctt tcactacact acaggatatg atctccatgt     3060

agtccatata aacctgcaga gtgattttcc agagtgctcg atactgttaa ttacatctcc     3120

attagggctg aaaagaatga cctacgtttc tgtatacagc tgtgttgctt ttgatgttgt     3180

gttactgtac acagaagtgt gtgcactgag gctctgcgtg tggtccgtat ggaaagcctg     3240

gtagccctgc gagttaagta ctgcttccat tcattgttta cgctggaatt tttctcccca     3300

tggaatgtaa gtaaaactta agtgtttgtc atcaataaat ggtaatacta aatttttttg     3360

ttaatttatt ctcaaatgcc actactgcta ggttggtccc ctcccaactt gcccctatcc     3420

tttttttatt tttaagaaaa aaactttgta atgcttgtga ttccatctgg gcaaaagtct     3480

gaagatctga aataacttta tatcaaacca ttgatcaata aacagctact aatg           3534


<210> 1774
<211> 1454
<212> DNA
<213> Homo sapiens

<400> 1774
gccgcgtctt cctgaggtag ctcctgtcag cccactgatc ccaccacccg ctccctactg       60

ccccgcggtc ttcgcgtgag ctcggagact gagggacaac aaaaatggcg gaggggagcc      120

agtcggcgcc tgaggcaggc aatgatatgg gaaatgatga tgccattgga gggaatgtga      180

gcaaatatat agtgcttcca actggctatt gtggacagcc caagaaagga catcttatct      240

ttgatgcttg ctttgaaagt ggtaacctgg gccgggtgga ccaggtctct gagtttgagt      300

atgatctgtt cattaggccg gacacctgta atccacgctt ccgagtctgg ttcaacttta      360

ctgttgaaaa tgtgaaagaa tcacagaggg tcattttcaa cattgttaac ttcagtaaaa      420

ccaagagtct ctatagagat gggatggccc ctatggtgaa atctaccagc agaccaaaat      480

ggcaaaggct gccacccaaa aatgtttact actaccgctg cccggaccat aggaagaact      540

atgtgatgtc ctttgccttt tgttttgacc gagaagaaga tatttaccag tttgcttact      600

gctacccata tacatacact cgcttccaac attaccttga cagcctgcaa aagagaaaca      660

tggattactt ctttcgggag cagctgggcc agagtgtgca acaacgaaag cttgacctcc      720

tgacgataac cagccctgct ggaagatgga gctggtgaaa tcatttgctt ctgaaggaga      780

atggtggcct ttccaaattt gactatcaga tatgaatttg acctaatctc gggaatgttt      840

ccggctggaa gatggagctg gtgaaatcat ttgcttctga aggagaatgg tggcctttcc      900

aaatttgact atcagatatg aatttgacct aatctcggga atgtttccgg taagactgca      960

gactctcagg tgcttaagaa gtcactgagg ctctggacaa acaggaacgt attagctttt     1020

tgcctactga ctacacagcc tccaccattc acccaaaatg gatctgcatc tcccaggtgc     1080

atctgcaagc acacaaaaac acacactggg aaggggtatg agctgaggtt agtcctaggt     1140

gctgcacttt ctattcctga catatcagga tgtgtgggag ggaggccaaa gctgcagcac     1200

caggctgggc ttccagtcct gttgctactg tggaagctgg ctccagacag gtgggggcag     1260

caaagagcca gcctgtatgg tcagctggga ttctagttga ccaaagctgt tgggagaact     1320

caagctcatc agtgtggcaa gttagacaac ttgatctgga cacatgcata aatggaacag     1380

gggtccagat acccacagga ttaatactaa taaaccattt tgcttaagca gcaaaactcg     1440

gtttatatat tgaa                                                       1454


<210> 1775
<211> 1353
<212> DNA
<213> Homo sapiens

<400> 1775
aggcaaccgt cgtgccgcgt cttcctgagg tagctcctgt cagcccactg atcccaccac       60

ccgctcccta ctgccccgcg gtcttcgcgt gagctcggag actgagggac aacaaaaatg      120

gcggagggga gccagtcggc gcctgaggca ggcaatgata tgggaaatga tgatgccatt      180

ggagggaatg tgagcaaata tatagtgctt ccaactggct attgtggaca gcccaagaaa      240

ggacatctta tctttgatgc ttgctttgaa agtggtaacc tgggccgggt ggaccaggtc      300

tctgagtttg agtatgatct gttcattagg ccggacacct gtaatccacg cttccgagtc      360

tggttcaact ttactgttga aaatgtgaaa gaatcacaga gggtcatttt caacattgtt      420

aacttcagta aaaccaagag tctctataga gatgggatgg cccctatggt gaaatctacc      480

agcagaccaa aatggcaaag gctgccaccc aaaaatgttt actactaccg ctgcccggac      540

cataggaaga actatgtgat gtcctttgcc ttttgttttg accgagaaga agatatttac      600

cagtttgctt actgctaccc atatacatac actcgcttcc aacattacct tgacagcctg      660

caaaagagaa acatggatta cttctttcgg gagcagctgg gccagagtgt gcaacaacga      720

aagcttgacc tcctgacgat aaccagccct gacaatctcc gggaaggggc agagcagaag      780

gtggtattca tcacaggacg agtccaccca ggggaaacac cctcatcatt tgtgtgccaa      840

gggatcattg acttccttgt aagccagcac cctattgcct gtgtcctccg ggaatacctg      900

gtcttcaaga tcgcaccaat gctcaatcct gatggagtct acctgggcaa ttacaggtgt      960

tctctgatgg gatttgatct gaatcgtcac tggctggatc cctctccatg ggtccatcct     1020

accctgcatg gagtgaaaca actcatcgtc cagatgtaca acgacccagt aagtaactga     1080

atgccctcca cagctgctga tctatggctt gatctgggaa agggcagcat tgtattggga     1140

aagtccacta gaagctgcaa attaggaata catagctaaa accagggagg cactaggcct     1200

gctcttctct gaatccagca gacccaagga ccttctccca atctcttttc ctgcaacctc     1260

tcacaaatag tggattcagt tttggaggtc tggagggtta aaggaaatat attggagtgt     1320

atccatattt gtcagggatc tttggttaca agc                                  1353


<210> 1776
<211> 2947
<212> DNA
<213> Homo sapiens

<400> 1776
aggcaaccgt cgtgccgcgt cttcctgagg tagctcctgt cagcccactg atcccaccac       60

ccgctcccta ctgccccgcg gtcttcgcgt gagctcggag actgagggac aacaaaaatg      120

gcggagggga gccagtcggc gcctgaggca ggcaatgata tgggaaatga tgatgccatt      180

ggagggaatg tgagcaaata tatagtgctt ccaactggct attgtggaca gcccaagaaa      240

ggacatctta tctttgatgc ttgctttgaa agtggtaacc tgggccgggt ggaccaggtc      300

tctgagtttg agtatgatct gttcattagg ccggacacct gtaatccacg cttccgagtc      360

tggttcaact ttactgttga aaatgtgaaa gaatcacaga gggtcatttt caacattgtt      420

aacttcagta aaaccaagag tctctataga gatgggatgg cccctatggt gaaatctacc      480

agcagaccaa aatggcaaag gctgccaccc aaaaatgttt actactaccg ctgcccggac      540

cataggaaga actatgtgat gtcctttgcc ttttgttttg accgagaaga agatatttac      600

cagtttgctt actgctaccc atatacatac actcgcttcc aacattacct tgacagcctg      660

caaaagagaa acatggatta cttctttcgg gagcagctgg gccagagtgt gcaacaacga      720

aagcttgacc tcctgacgat aaccagccct gacaatctcc gggaaggggc agagcagaag      780

gtggtattca tcacaggacg agtccaccca ggggaaacac cctcatcatt tgtgtgccaa      840

gggatcattg acttccttgt aagccagcac cctattgcct gtgtcctccg ggaatacctg      900

gtcttcaaga tcgcaccaat gctcaatcct gatggagtct acctgggcaa ttacaggtgt      960

tctctgatgg gatttgatct gaatcgtcac tggctggatc cctctccatg ggtccatcct     1020

accctgcatg gagtgaaaca actcatcgtc cagatgtaca acgacccaaa aacaagcctg     1080

gagttttata ttgacatcca tgcccactcc accatgatga atggcttcat gtatggcaac     1140

atctttgagg atgaggaacg gttccagagg caggccattt ttcccaagct cctctgccag     1200

aatgctgagg acttctccta ttccagcaca tcctttaacc gggacgctgt gaaagcagga     1260

actggccgtc gcttcctcgg tggactcctg gaccacactt cctattgcta caccctagag     1320

gtctccttct acagctacat catcagtggc accacggctg ctgtgcccta cactgaagaa     1380

gcctatatga agctggggcg gaatgtggca agaacctttt tggactatta tcggctgaac     1440

cccgtggttg aaaaggtggc aattcccatg ccgagactgc gaaataaaga aatagaagtc     1500

cagagaagga aagaaaaatc ccctccttac aagcacccac tcctgcgggg cccagccagc     1560

aactacccca acagcaaagg ggacaagaag agctcagtga accacaaaga cccttcaacc     1620

cctttttaaa gacacggagt cctgggaggt cttatgggga caggagcatg cattttctgc     1680

tggggaatga aattaatcac tcttctctag cttccaagga tttgtggatt aatgcatagg     1740

ctagtgaaag ggaagggata caatgagaaa cttcatcact gattttccct ttttccaatg     1800

gaaaatcaat tgtaagcctt cagctcaaaa agctcaggaa caaaatagga gatcggaacc     1860

aggtgagcac agatgctatt ttctacaaca tagagatctt ccaagatgag gaaaacctac     1920

acatcccttt taagagattt gacacatatc aggtcagttc tttcaaagcc actttacatt     1980

tttaagtttt atagttactg cagatggtta ccttttaaat aggcttggtt gtttacagct     2040

ttagaaatgc agtgtttgta ttttctgatc caaaacaaca gcaacaacac atgcaaccaa     2100

agggcaaatg catcctaggg aacaatggga cagaattttt gaaatcaacg gtggacttaa     2160

atatatggtc actgtatcta agctgcatgc ttgctgattc cctcaaaccc cagcatgcag     2220

atttagaaaa ctgttttgag agctgtttcc caatttcctc ggtagtttaa ttaaaatttt     2280

agctctaaag acaaaaagca ctggtcactc attttaaaag gtttattatg gttaaggtct     2340

ccagatccca ggtgacaggg attaagcctg gcccctgaag atgtaggcat tgctaatctg     2400

caatgaggaa agggtgattg ccaggcaagg aagatgcaaa agacagaagg atgcaccctg     2460

aggcagggag gaatgataaa ataaaacagt agtagcaatt cccaaggtgt ggcaagctaa     2520

atattggcat ttttgtgaag agtaaagtgc ctttgtatga tgaatgggtc caggggggtc     2580

tgctcccttc ctgtctgtgg aaacagcagg ctgagtcacc atgacagcct gctaattaaa     2640

atgacctccc ggaaatgagg attagaacac agggagagga agggaggctc cagggaggaa     2700

aatcccttag cacagagctc cactaaagca ttttttgttt gtttgtttgt ttgtttgttt     2760

gtttgagttg gagattattg aagtttgcta caaaaatcaa aaagaaaact tgttctcctt     2820

tgcatgctag ttttcagaaa tgatgacaaa gagccatatg ttgattggct acaaatgtca     2880

tgttgtatat acagcttctc ccctgggttc gttttgccca gaggaacaca aataaagtgt     2940

tttgtgc                                                               2947


<210> 1777
<211> 3500
<212> DNA
<213> Homo sapiens

<400> 1777
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc agagtttatt aaccacttaa cctctcagaa ctgaacaaag acaacattgt      300

tcctggaacg ccctcttttt aaaaaaggta gaactttaga cttcatagca ctgaattaac      360

ctgcactgaa agctgtttac ctgcatttgt tcacttttgt tgaaagtgac catgtctcaa      420

gttcaagtgc aagttcagaa cccatctgct gctctctcag ggagccaaat actgaacaag      480

aaccagtctc ttctctcaca gcctttgatg agtattcctt ctactactag ctctctgccc      540

tctgaaaatg caggtagacc cattcaaaac tctgctttac cctctgcatc tattacatcc      600

accagtgcag ctgcagaaag cataacccct actgtagaac taaatgcact gtgcatgaaa      660

cttggaaaaa aaccaatgta taagcctgtt gacccttact ctcggatgca gtccacctat      720

aactacaaca tgagaggagg tgcttatccc ccgaggtact tttacccatt tccagttcca      780

cctttacttt atcaagtgga actttctgtg ggaggacagc aatttaatgg caaaggaaag      840

acaagacagg ctgcgaaaca cgatgctgct gccaaagcgt tgaggatcct gcagaatgag      900

cccctgccag agaggctgga ggtgaatgga agagaatccg aagaagaaaa tctcaataaa      960

tctgaaataa gtcaagtgtt tgagattgca cttaaacgga acttgcctgt gaatttcgag     1020

gtggcccggg agagtggccc accccacatg aagaactttg tgaccaaggt ttcggttggg     1080

gagtttgtgg gggaaggtga agggaaaagc aagaagattt caaagaaaaa tgccgccata     1140

gctgttcttg aggagctgaa gaagttaccg cccctgcctg cagttgaacg agtaaagcct     1200

agaatcaaaa agaaaacaaa acccatagtc aagccacaga caagcccaga atatggccag     1260

gggatcaatc cgattagccg actggcccag atccagcagg caaaaaagga gaaggagcca     1320

gagtacacgc tcctcacaga gcgaggcctc ccgcgccgca gggagtttgt gatgcaggtg     1380

aaggttggaa accacactgc agaaggaacg ggcaccaaca agaaggtggc caagcgcaat     1440

gcagccgaga acatgctgga gatccttggt ttcaaagtcc cgcaggcgca gcccaccaaa     1500

cccgcactca agtcagagga gaagacaccc ataaagaaac caggggatgg aagaaaagta     1560

accttttttg aacctggctc tggggatgaa aatgggacta gtaataaaga ggatgagttc     1620

aggatgcctt atctaagtca tcagcagctg cctgctggaa ttcttcccat ggtgcccgag     1680

gtcgcccagg ctgtaggagt tagtcaagga catcacacca aagattttac cagggcagct     1740

ccgaatcctg ccaaggccac ggtaactgcc atgatagccc gagagttgtt gtatgggggc     1800

acctcgccca cagccgagac cattttaaag aataacatct cttcaggcca cgtaccccat     1860

ggacctctca cgagaccctc tgagcaactg gactatcttt ccagagtcca gggattccag     1920

gttgaataca aagacttccc caaaaacaac aagaacgaat ttgtatctct tatcaattgc     1980

tcctctcagc cacctctgat cagccatggt atcggcaagg atgtggagtc ctgccatgat     2040

atggctgcgc tgaacatctt aaagttgctg tctgagttgg accaacaaag tacagagatg     2100

ccaagaacag gaaacggacc aatgtctgtg tgtgggaggt gctgaacctt ttctggccat     2160

gaaccattat aaaatcccaa catatatact gaaaatactg aaactgcttt gaaaatttgg     2220

aatttctgat acctccagtg ggccgagaga cacggtgggt aaaggatgtg ggcagcagca     2280

gggaagacaa cagaaacaca aggaggcggc tgtggccggg ctggactgtg ctggggtttg     2340

ttgtgatggc cactcggtga cctggcggtc cctacgcaat agcagctgcc tgtggggaag     2400

aagggctgcc cagccagctg gttctcccgg gacaccagca gatccacacc ctgggcacct     2460

ccgtgtttgg tctttttttt cccctgtgtg aaagaagaaa cggcacgacc ccttctcaag     2520

ctggctcact cagacacatt gggacaaacc ctggacagcc atgccagaga gaggcctttg     2580

accggcccca gagctaaaag caccagagaa aatcaaatgc ttcctactca gcgtgaccca     2640

acttttctag tgtgccacgg ccccaccacc tcctgcagta cccacaccat caccactgct     2700

ttctcttcca acagtgatct gtattcttag tttcattatt ttcttttgat tgatatgaca     2760

ctatataaaa ttttcatttg agaatttctc aattgtatct agttaaatag cacagtttgg     2820

aaacttgtct gagactgact ttatcaataa tctaaccgac aaagatcata tccatgtgta     2880

tgtggttaga catttttatt tcattgacta acccaggaca gtttcagtga tgcaaattgt     2940

gtgccctctg gttcagctga aacagtcctg gactttcaaa aaccttgaat aagtctccca     3000

cagttgtata aattggacaa tttaggaatt ttaaacttta gatgatcatt tggttccatt     3060

tttatttcat ttttattttt gttaatgcaa acaggactta aatgaacttt gatctctgtt     3120

ttaaagatta ttaaaaaaca ttgtgtatct atacatatgg ctcttgagga cttagctttc     3180

actacactac aggatatgat ctccatgtag tccatataaa cctgcagagt gattttccag     3240

agtgctcgat actgttaatt acatctccat tagggctgaa aagaatgacc tacgtttctg     3300

tatacagctg tgttgctttt gatgttgtgt tactgtacac agaagtgtgt gcactgaggc     3360

tctgcgtgtg gtccgtatgg aaagcctggt agccctgcga gttaagtact gcttccattc     3420

attgtttacg ctggaatttt tctccccatg gaatgtaagt aaaacttaag tgtttgtcat     3480

caataaatgg taatactaaa                                                 3500


<210> 1778
<211> 1326
<212> DNA
<213> Homo sapiens

<400> 1778
ggaccctgaa ggagggacag ggcacctcgg tggtggccca aggcccaagc cggcccctgc       60

ccagcacggc caacgtggtg gtcattggtg gaggcagctt gggctgccag accctgtacc      120

acctggccaa gctgggcatg agtggggcgg tgctgctgga gcgggagcgg ctgacctccg      180

ggaccacctg gcacacggca ggcctgctgt ggcagctgcg gcccagtgac gtggaggtgg      240

agcttctggc ccacactcgg cgggtggtga gccgggagct ggaggaggag acgggactac      300

acacgggctg gatccagaat gggggcctct tcatcgcgtc caaccggcag cgcctggacg      360

agtacaagag gctcatgtcg ctgggcaagg cgtatggtgt ggaatcccat gtgctgagcc      420

cggcagagac caagactctg tacccgctga tgaatgtgga cgacctctac gggaccctgt      480

atgtgccgca cgacggtacc atggaccccg ctggcacctg taccaccctc gccagggcag      540

cttctgcccg aggagcacag gtcattgaga actgcccagt gaccggcatt cgtgtgtgga      600

cggatgattt tggggtgcgg cgggtcgcgg gtgtggagac tcagcatggt tccatccaga      660

caccctgcgt ggtcaactgt gcaggagtgt gggcaagtgc tgtgggccgg atggctggag      720

tcaaggtccc gctggtggcc atgcaccatg cctatgtcgt caccgagcgc atcgagggga      780

ttcagaacat gcccaatgtc cgtgatcatg atgcctctgt ctacctccgc ctccaagggg      840

atgccttgtc tgtgggtggc tatgaggcca accccatctt ttgggaggag gcagtcaaat      900

acagacccag ggcagctgga gggctttgcc tcaaaacatc cacagagaag gtctgcgcag      960

tgtggagtga tgacctcaga agggcatgag agcacacaag tcctacgtcc ttcagcaaat     1020

gacactgccc tcccaaccag ctgctgcagc ggcatttccc ctggcctggg ctgtttcccg     1080

ggcagcttct ggggttaggg cagccctgca gccctgttct atgtgtatat gcatttagtc     1140

cacacatgga acgactgagt ggctactttg ggctaaaaac tgctttaatt tctggagaaa     1200

gagggaaact aagataaaag tccctgactc tgggtgccta tattttggtg gagagacata     1260

caataaacaa acaaatggct gggcacggtg gctcacacct gtaatcccag cactttggga     1320

ggctga                                                                1326


<210> 1779
<211> 2266
<212> DNA
<213> Homo sapiens

<400> 1779
gtgccgtgtc ggcagttagg agggcaggtg gcggggtggg gggttgtctg caggagcagc       60

ggccagggag gggcatgggg ctgtggggct gtggggtgtc tgatgggggc agatcccagg      120

gaggccaagg cagtggcaga aaagctggac tctggagccc acgcacctgc ctggcttcgt      180

gccactgcca ggtccaggac ttgtctgtgc ccttgggcga gatataactt ctctgcgcct      240

cactttcctc atctgtagaa aggggcacac ctggtaggag tgtaagacgc ttcccgcagg      300

ggctggccca gagcaggagc tgggcctggg attgccgtgg ctccagggag cagccctggc      360

tgaggtcctg ggtaaccacc tctccctgtc gttccccacc ttgggtgcat ccagctcctc      420

ctccagcctc ctgggccctg gctgggctct cagacccacc aggcaaccct gcggcctcct      480

ttgtgcctct gttttgcctg gacctcatgg gggccccctg cccgcgtcca caacacacgg      540

gcactcagtg cagggctctc cgagggcagg gccaggcctg accccatcac agcctcagcg      600

ggaccccgct ctggggaggg aagcggggag gggccaaaga ggcaggctga ggaccacgtc      660

ttttcttccc aggtcctcga gtacgactac tacggggctt acgggagccg cgcgcacgag      720

gactacgcct accgcaggct gctggcagac gagtacacct tcgccttccc gccccaccac      780

gacacgatca agaaggagtg cctggcctgc agaggggccg ccgctgtgtt tgacatgtcc      840

tacttcggga agttctacct ggtggggctg gatgcaagga aggctgccga ctggctcttc      900

tccgcagatg tcagccgacc cccaggctcc accgtgtaca cgtgcatgct caaccaccgt      960

gggggcaccg agagtgacct gactgtcagc cgcctggcac ccagccacca ggcctccccg     1020

ctggcccccg cctttgaagg ggacggttac tacctggcca tgggcggggc cgtggcccag     1080

cacaactggt cccacatcac caccgtgctg caggaccaga agtcccagtg ccagctcatc     1140

gacagctccg aggacctggg tatgatcagt atccagggcc cagccagccg agccattttg     1200

caggaggtgc tggacgcaga cctgagcaac gaggccttcc cgttctccac ccacaagcta     1260

ctgagagccg cagggcacct ggtccgagcc atgcggctgt cctttgtggg ggagctgggc     1320

tgggagctgc acattccaaa ggcgtcctgc gtgcctgtgt accgggctgt gatggccgcg     1380

ggtgccaagc acggcctcat caacgcaggg taccgcgcca tcgactccct gagcattgag     1440

aaaggctacc ggcactggca cgcggacctg cggccagacg acagccccct ggaggcaggc     1500

ctggccttca cctgcaagct caagtcgccg gtgcccttcc tggggaggga ggccctggag     1560

cagcagcggg ccgcaggcct ccgccggcgc ctggtgtgct tcaccatgga ggagccgctg     1620

tggacgcgtc cccaccctgc ggtttctggg gccccagctt tctctactgc ttcttccagc     1680

aaagtaccca tgtttggcct ggaggccatc tggaggaacg gccaagtggt gggccatgtc     1740

cggagggctg actttgggtt cgccatcgac aagaccatcg cctacggtta catccatgac     1800

cccagcggtg ggccggtctc gctggacttt gtgaagagcg gggactatgc cctggagaga     1860

atgggggtga cctatggtgc ccaggctcac ctgaagtcgc ccttcgaccc caacaacaag     1920

agggtgaagg gaatctactg agggctcaga ccacatgccc catcccatgc tgtccatcca     1980

ttctcacagg tcccaaatgg ccctgggtcc caggaccctg gacccagcca gaacttgtgc     2040

cctccctgtc cttagcctag gcctagtcct gcgaaaaccc ccaaaccaga tacggacaga     2100

gaccaagatg gcccatcctg tggtcactga ctggaaggca gtctctaatc caccccaatc     2160

ctcccagaaa gcaaacctgt aagtgtcttg ggctcaggga ccatggcttg tagccctttc     2220

caagcttcta gaaggtgctt agtaaatact tgataagccc cacgtg                    2266


<210> 1780
<211> 3344
<212> DNA
<213> Homo sapiens

<400> 1780
agtgtgggct acccggccac tgccctggag ctgtggtgac tgctgcgttt ttctcccatg       60

cacttgcacg tccaggactc ctgggagaac ttgggccaca ctccttcctt gccctcttga      120

gctcattcgt caccctgttg ggtgagcaca gccctagctc aggccactgg gcaagccaca      180

ccatccaaag aggaggtcct ctgccccagg acccccacac caccccagct ccctgtttcg      240

ctgaggcctg gagcccccat ggcctcactg agccgagccc tacgtgtggc tgctgcccac      300

cctcgccaga gccctacccg gggcatgggg ccatgcaacc tgtccagcgc agctggcccc      360

acagccgaga agagtgtgcc atatcagcgg accctgaagg agggacaggg cacctcggtg      420

gtggcccaag gcccaagccg gcccctgccc agcacggcca acgtggtggt cattggtgga      480

ggcagcttgg gctgccagac cctgtaccac ctggccaagc tgggcatgag tggggcggtg      540

ctgctggagc gggagcggct gacctccggg accacctggc acacggcagg cctgctgtgg      600

cagctgcggc ccagtgacgt ggaggtggag cttctggccc acactcggcg ggtggtgagc      660

cgggagctgg aggaggagac gggactacac acgggctgga tccagaatgg gggcctcttc      720

atcgcgtcca accggcagcg cctggacgag tacaagaggc tcatgtcgct gggcaaggcg      780

tatggtgtgg aatcccatgt gctgagcccg gcagagacca agactctgta cccgctgatg      840

aatgtggacg acctctacgg gaccctgtat gtgccgcacg acggtaccat ggaccccgct      900

ggcacctgta ccaccctcgc cagggcagct tctgcccgag gagcacaggt cattgagaac      960

tgcccagtga ccggcattcg tgtgtggacg gatgattttg gggtgcggcg ggtcgcgggt     1020

gtggagactc agcatggttc catccagaca ccctgcgtgg tcaactgtgc aggagtgtgg     1080

gcaagtgctg tgggccggat ggctggagtc aaggtcccgc tggtggccat gcaccatgcc     1140

tatgtcgtca ccgagcgcat cgaggggatt cagaacatgc ccaatgtccg tgatcatgat     1200

gcctctgtct acctccgcct ccaaggggat gccttgtctg tgggtggcta tgaggccaac     1260

cccatctttt gggaggaggt gtcagacaag tttgccttcg gcctctttga cctggactgg     1320

gaggtgttca cccagcacat tgaaggcgcc atcaacaggg tccccgtgct ggagaagaca     1380

ggaatcaagt ccacggtctg cggccctgaa tccttcacgc ccgaccacaa gcccctgatg     1440

ggggaggcac ctgagctccg agggttcttc ctgggctgtg gcttcaacag cgcaggaatg     1500

atgctgggtg gtggctgtgg gcaggagctg gcccactgga tcatccatgg gcgcccggag     1560

aaggacatgc atggctatga catcaggcgc ttccatcact cgctcacgga ccacccccgc     1620

tggatccgag agcgaagcca tgagtcctac gccaagaact actccgtcgt cttcccccac     1680

gatgagccgc tggccgggcg caacatgagg agagacccgc tgcacgagga actccttgga     1740

caaggctgcg tgttccagga gcggcatggc tgggagcgac cgggatggtt tcatccccga     1800

ggcccagctc cggtcctcga gtacgactac tacggggctt acgggagccg cgcgcacgag     1860

gactacgcct accgcaggct gctggcagac gagtacacct tcgccttccc gccccaccac     1920

gacacgatca agaaggagtg cctggcctgc agaggggccg ccgctgtgtt tgacatgtcc     1980

tacttcggga agttctacct ggtggggctg gatgcaagga aggctgccga ctggctcttc     2040

tccgcagatg tcagccgacc cccaggctcc accgtgtaca cgtgcatgct caaccaccgt     2100

gggggcaccg agagtgacct gactgtcagc cgcctggcac ccagccacca ggcctccccg     2160

ctggcccccg cctttgaagg ggacggttac tacctggcca tgggcggggc cgtggcccag     2220

cacaactggt cccacatcac caccgtgctg caggaccaga agtcccagtg ccagctcatc     2280

gacagctccg aggacctggg tatgatcagt atccagggcc cagccagccg agccattttg     2340

caggaggtgc tggacgcaga cctgagcaac gaggccttcc cgttctccac ccacaagcta     2400

ctgagagccg cagggcacct ggtccgagcc atgcggctgt cctttgtggg ggagctgggc     2460

tgggagctgc acattccaaa ggcgtcctgc gtgcctgtgt accgggctgt gatggccgcg     2520

ggtgccaagc acggcctcat caacgcaggg taccgcgcca tcgactccct gagcattgag     2580

aaaggctacc ggcactggca cgcggacctg cggccagacg acagccccct ggaggcaggc     2640

ctggccttca cctgcaagct caagtcgccg gtgcccttcc tggggaggga ggccctggag     2700

cagcagcggg ccgcaggcct ccgccggcgc ctggtgtgct tcaccatgga ggacaaagta     2760

cccatgtttg gcctggaggc catctggagg aacggccaag tggtgggcca tgtccggagg     2820

gctgactttg ggttcgccat cgacaagacc atcgcctacg gttacatcca tgaccccagc     2880

ggtgggccgg tctcgctgga ctttgtgaag agcggggact atgccctgga gagaatgggg     2940

gtgacctatg gtgcccaggc tcacctgaag tcgcccttcg accccaacaa caagagggtg     3000

aagggaatct actgagggct cagaccacat gccccatccc atgctgtcca tccattctca     3060

caggtcccaa atggccctgg gtcccaggac cctggaccca gccagaactt gtgccctccc     3120

tgtccttagc ctaggcctag tcctgcgaaa acccccaaac cagatacgga cagagaccaa     3180

gatggcccat cctgtggtca ctgactggaa ggcagtctct aatccacccc aatcctccca     3240

gaaagcaaac ctgtaagtgt cttgggctca gggaccatgg cttgtagccc tttccaagct     3300

tctagaaggt gcttagtaaa tacttgataa gccccacgtg aaaa                      3344


<210> 1781
<211> 1854
<212> DNA
<213> Homo sapiens

<400> 1781
ggttttgctc cgctttagca gcggcgaagg gaggaccccc gggagccggt ccccggcgtc       60

cggtcgccca gcccttttca ggcttgggcc cgcatggagg ggaccgtgga gtcccagacg      120

cctgacctgc gggatgtgga gggtaaggtg ggcaggaaga cccctgaagg gctgctccgc      180

gggctgcgag gcgagtgtga gctgggaacc tctggcgccc tgctgctccc aggggcgtct      240

agcaccggcc acgacttggg ggacaagatc atggcgctga agatggagct ggcttacctg      300

cgagccatcg atgtgaagat cctgcagcag ctggtgacct tgaatgaggg catcgaggca      360

gtgcgctggc tgttggagga gcgggggacg ttgaccagtc attgcagcag cctcaccagc      420

agtcaatata gcctgacagg cgggagccca ggccgctcaa ggcgaggcag ctgggacagc      480

ctgccagaca ccagcaccac cgaccggctg gacagtgtct ctattggcag cttcctggac      540

acagtggccc ccagcgagct ggatgaacag ggcccacctg gggctccacg ttccgagatg      600

gactgggcaa aagttatagc tggtggagag agggccagga ctgaggtgga tgtggcagcc      660

accaggctag ggagcttgag agctgtgtgg aagcccccag gggagaggct tcaaggtgga      720

ccacctgagt caccagagga tgagagtgcc aagctgggct tcgaggccca ctggttctgg      780

gagcagtgcc aggatgatgt gaccttcttg taacaactat tccacccttt tgtaatcctg      840

tggctctttt atccattaga tgtggtctcc cccaaaattg attctccctc agtctgagac      900

taggaagagg ctgcactgaa atcagttacc atggaaacct ggctcatcat ttctctagtc      960

cctagggagt ctctgccttt atccctcaat tattgggtcc ctagagctag cttgctcttt     1020

ctttctttct ttcttttttt gagacagggt cttatgctgt tacccaagat agagagcagt     1080

ggcatgatca cagctcactg cagccttgac ctcctgggct caagcgatcc tcctatttca     1140

gcctccccca tagttaggac cacaggcatg caccaccatg cccagctaat tgtttattta     1200

tttatttttt ttttgtagag atagggtttc cctgtgttgc ccaggctggt ctcaaactcc     1260

tgggctcaag ggatcctccc gcctcagcct cccaaagtgc tgggattatg cccagcccct     1320

agagatactt ctatagagat attgactcta aaggattgac ctatggcttt tggtatttag     1380

tatctctcac tactcccccc agctaagtaa ggatttaagg aatttaggac tccctggagt     1440

taacagatga agagatgggg gcataattac ttcacccaaa gtctagaagc cttggcctct     1500

ctcttggcca agatggagga ttgaggaggg acatggacct tcaggactaa ccctctatgg     1560

attggccctc ccagaagcgt ttgggctggt agacccaccc cttcctacct gctgagtgat     1620

gtcatttcct gccaggatgg gtagcccttt gtacgggtcc ttggatggta gtaggtcata     1680

taggggcatc tgagcccctg ctgctaagtg agatcacatt atttatcgtc cataccatta     1740

cttcttgtga acagtaacat gtcactcctc ctggcaggaa agtttctcat tgtcagatgt     1800

ttgtgcttct tttcaggtct tactttttaa atagagtgtt ctcattttat ccta           1854


<210> 1782
<211> 609
<212> DNA
<213> Homo sapiens

<400> 1782
agtttctgcg acttgtgttg ggactgctga taggaagatg tcttcaggaa atgctaaaat       60

tgggcaccct gcccccaact tcaaagccac agctgatgaa ggcatctcgt tcaggggcct      120

ttttatcatt gatgataagg gtattcttcg gcagatcact gtaaatgacc tccctgttgg      180

ccgctctgtg gatgagactt tgagactagt tcaggccttc cagttcactg acaaacatgg      240

ggaagtgtgc ccagctggct ggaaacctgg cagtgatacc atcaagcctg atgtccaaaa      300

gagcaaagaa tatttctcca agcagaagtg agcgctgggc tgttttagtg ccaggctgcg      360

gtgggcagcc atgagaacaa aacctcttct gtattttttt tttccattag taaaacacaa      420

gacttcagat tcagccgaat tgtggtgtct tacaaggcag gcctttccta cagggggtgg      480

agagaccagc ctttcttcct ttggtaggaa tggcctgagt tggcgttgtg ggcaggctac      540

tggtttgtat gatgtattag tagagcaacc cattaatctt ttgtagtttg tattaaactt      600

gaactgaga                                                              609


<210> 1783
<211> 3028
<212> DNA
<213> Homo sapiens

<400> 1783
tcagtctttc gcggcccggg agctcagcag agctaccagc tgccctgttg gcttcgctgg       60

tcggatcgtc ctcctggccc cgccaaacag gcggggggag cggccccgac tgtggggcca      120

tggcagtagt ctcctcgttc gccgccgccg ctagcctagc tgagtcgccg gcttctgcgc      180

taggggctcc caccgcctcc gcaggctaag gagccgctgc caccaacgag ctgtgagggt      240

tactatgctc cctctttgcc gccgtctcct cctcttgccc gcgcaggcac ccctctggct      300

gctcagtcct gcctcagtgt caaaccagaa gagaagtaaa attcaacaaa aatttatgtg      360

tggagttcct tcttaaaaga agaaaaaagt gattatttag actatggatc ggagcaaacg      420

gaattcaatt gcaggatttc ctccacgtgt ggagcgtctt gaagagtttg aaggaggtgg      480

tggaggagaa ggaaatgtga gccaggtggg aagagtttgg ccatcttcgt atcgagctct      540

tataagtgcc ttttccagac tgacgcgttt ggatgatttc acctgtgaaa aaatagggtc      600

tggcttcttt tctgaagtgt tcaaggtacg acaccgagct tctggtcagg tgatggctct      660

taagatgaac acattgagca gtaaccgggc aaacatgctg aaagaagtac agctcatgaa      720

tagactctcc catcccaaca tccttaggta tatcaactcc gggaacctgg aacagttgct      780

agacagtaac ctgcatttgc cttggactgt gagggtaaaa ctggcctatg acatagcagt      840

gggcctcagc taccttcact tcaaaggcat ttttcatcgg gacctcacat ctaagaactg      900

cctgataaag agggatgaga atggttactc tgcagtggta gctgactttg gcctggctga      960

gaagatcccc gatgtcagca tggggagtga gaagctggcc gtggtgggtt ccccattctg     1020

gatggcacct gaggttctcc gagatgagcc ctataatgaa aaggcagatg tgttctctta     1080

tggtatcatc ctctgcgaga tcatcgcccg catccaggcc gatccggact atcttccccg     1140

cacagagaat ttcgggctgg actatgatgc tttccagcac atggtgggag actgtccccc     1200

agattttctg caacttactt tcaactgctg taacatggat cccaaactgc gcccatcttt     1260

tgtggagatt gggaagaccc tggaggaaat tctgagccgc ctacaggaag aagagcagga     1320

gagggatagg aagctgcagc ccacagccag gggactcttg gagaaagcac ctggggtgaa     1380

gcgactaagc tcactggatg acaagatccc ccacaagtca ccatgcccaa gacgtaccat     1440

ctggctgtct cgaagccagt cagatatctt ttcccgtaag cccccacgta cagtgagtgt     1500

cttggaccca tactaccggc cacgagatgg tgctgcccgc acccccaaag tcaacccttt     1560

tagtgctcgc caggacctca tggggggcaa gatcaagttt tttgacctgc ccagcaagtc     1620

tgtcatctct ctggtatttg acctggatgc accagggccc ggaactatgc ccctggctga     1680

ctggcaggag cccctggccc cacctattcg ccggtggcgt tccttgcctg gttcgcctga     1740

gttcttgcat caagaggctt gtccatttgt gggccgggaa gaatcgctat ctgatgggcc     1800

cccaccacgc ctaagtagtc tcaagtacag agttaaagag atcccaccat tccgggcatc     1860

tgccctacca gctgctcaag cccatgaggc tatggactgc tccattctcc aggaagaaaa     1920

tggttttggg tccaggcccc aggggaccag tccatgccct gcgggtgctt ctgaggagat     1980

ggaggtagaa gaaaggccag caggctcaac tccagccacc ttctccacct caggcatagg     2040

cctgcaaacc cagggaaagc aggatgggtg agggggttta gtccctgcct caccttgggg     2100

atggaccttc agctgaaacc atatggcccc ctaggtgcac agccttgatt cttccctgga     2160

gcctacagag caggcaggct aggccaagcc aggctcaact tctgggctcc cagtgcccat     2220

tggctgtgta tgacgggagg cagcagtgag aggccttcct agttagggcc aacagctgat     2280

accaagcctc tgaaatccag caaggaggtc tgcctcccac cagaccctct ccagtgtact     2340

tccccagata ggaccagagg atgtctagtt ctaggctgag ctggcaggca gctattaccc     2400

cggttctttc cccaccccag gtctgtctct tgccttttct tggggcatat aagctactga     2460

gtggaacatg gagctgatca agaggccgta atggtcatgg ctgtttccca gacctgaata     2520

ttggggtgct tcttgccagt attctaagac atttgagtaa ttgctgtttg cacttactgc     2580

atggtcagac cacgtcacta catttctatg caaggggaca gcaaggcagc gtggtggtca     2640

tggctcttag ctaacctatt caaagacctt ttcctgttga ttaatctatt ttcatattta     2700

taaaggagtc ttaatgttct gccccataag actttcaacc ttgtggttgg gagtggggct     2760

ggttttgtag gccctagggc ctgcttctat gtatttatca acatgtgata cattcaattg     2820

gttaaatggt ttatacaggg actgatttgc ttcccttcct gccatggctg gagctttggg     2880

aacagtctgt ccttacagag ctgcaataag aaataaccaa agatgaagct ggtcaaatat     2940

tttcataact tgcttctgtt gatttttttt tttgtaaaac tttcccaaga cattttcaga     3000

cttaaaaata aagtcagtgt tacaggtg                                        3028


<210> 1784
<211> 2600
<212> DNA
<213> Homo sapiens

<400> 1784
tgattattta gactatggat cggagcaaac ggaattcaat tgcaggattt cctccacgtg       60

tggagcgtct tgaagagttt gaaggaggtg gtggaggaga aggaaatgtg agccaggtgg      120

gaagagtttg gccatcttcg tatcgagctc ttataagtgc cttttccaga ctgacgcgtt      180

tggatgattt cacctgtgaa aaaatagggt ctggcttctt ttctgaagtg ttcaaggtac      240

gacaccgagc ttctggtcag gtgatggctc ttaagatgaa cacattgagc agtaaccggg      300

caaacatgct gaaagaagta cagctcatga atagactctc ccatcccaac atccttaggt      360

tcatgggtgt atgtgttcat caaggacaat tgcatgcact tacagagtat atcaactccg      420

ggaacctgga acagttgcta gacagtaacc tgcatttgcc ttggactgtg agggtaaaac      480

tggcctatga catagcagtg ggcctcagct accttcactt caaaggcatt tttcatcggg      540

acctcacatc taagaactgc ctgataaaga gggatgagaa tggttactct gcagtggtag      600

ctgactttgg cctggctgag aagatccccg atgtcagcat ggggagtgag aagctggccg      660

tggtgggttc cccattctgg atggcacctg aggttctccg agatgagccc tataatgaaa      720

aggcagatgt gttctcttat ggtatcatcc tctgcgagat catcgcccgc atccaggccg      780

atccggacta tcttccccgc acagagatgg atcccaaact gcgcccatct tttgtggaga      840

ttgggaagac cctggaggaa attctgagcc gcctacagga agaagagcag gagagggata      900

ggaagctgca gcccacagcc aggggactct tggagaaagc acctggggtg aagcgactaa      960

gctcactgga tgacaagatc ccccacaagt caccatgccc aagacgtacc atctggctgt     1020

ctcgaagcca gtcagatatc ttttcccgta agcccccacg tacagtgagt gtcttggacc     1080

catactaccg gccacgagat ggtgctgccc gcacccccaa agtcaaccct tttagtgctc     1140

gccaggacct catggggggc aagatcaagt tttttgacct gcccagcaag tctgtcatct     1200

ctctggtatt tgacctggat gcaccagggc ccggaactat gcccctggct gactggcagg     1260

agcccctggc cccacctatt cgccggtggc gttccttgcc tggttcgcct gagttcttgc     1320

atcaagaggc ttgtccattt gtgggccggg aagaatcgct atctgatggg cccccaccac     1380

gcctaagtag tctcaagtac agagttaaag agatcccacc attccgggca tctgccctac     1440

cagctgctca agcccatgag gctatggact gctccattct ccaggaagaa aatggttttg     1500

ggtccaggcc ccaggggacc agtccatgcc ctgcgggtgc ttctgaggag atggaggtag     1560

aagaaaggcc agcaggctca actccagcca ccttctccac ctcaggcata ggcctgcaaa     1620

cccagggaaa gcaggatggg tgagggggtt tagtccctgc ctcaccttgg ggatggacct     1680

tcagctgaaa ccatatggcc ccctaggtgc acagccttga ttcttccctg gagcctacag     1740

agcaggcagg ctaggccaag ccaggctcaa cttctgggct cccagtgccc attggctgtg     1800

tatgacggga ggcagcagtg agaggccttc ctagttaggg ccaacagctg ataccaagcc     1860

tctgaaatcc agcaaggagg tctgcctccc accagaccct ctccagtgta cttccccaga     1920

taggaccaga ggatgtctag ttctaggctg agctggcagg cagctattac cccggttctt     1980

tccccacccc aggtctgtct cttgcctttt cttggggcat ataagctact gagtggaaca     2040

tggagctgat caagaggccg taatggtcat ggctgtttcc cagacctgaa tattggggtg     2100

cttcttgcca gtattctaag acatttgagt aattgctgtt tgcacttact gcatggtcag     2160

accacgtcac tacatttcta tgcaagggga cagcaaggca gcgtggtggt catggctctt     2220

agctaaccta ttcaaagacc ttttcctgtt gattaatcta ttttcatatt tataaaggag     2280

tcttaatgtt ctgccccata agactttcaa ccttgtggtt gggagtgggg ctggttttgt     2340

aggccctagg gcctgcttct atgtatttat caacatgtga tacattcaat tggttaaatg     2400

gtttatacag ggactgattt gcttcccttc ctgccatggc tggagctttg ggaacagtct     2460

gtccttacag agctgcaata agaaataacc aaagatgaag ctggtcaaat attttcataa     2520

cttgcttctg ttgatttttt tttttgtaaa actttcccaa gacattttca gacttaaaaa     2580

taaagtcagt gttacaggtg                                                 2600


<210> 1785
<211> 3074
<212> DNA
<213> Homo sapiens

<400> 1785
agtctttcgc ggcccgggag ctcagcagag ctaccagctg ccctgttggc ttcgctggtc       60

ggatcgtcct cctggccccg ccaaacaggc ggggggagcg gccccgactg tggggccatg      120

gcagtagtct cctcgttcgc cgccgccgct agcctagctg agtcgccggc ttctgcgcta      180

ggggctccca ccgcctccgc aggctaagga gccgctgcca ccaacgagct gtgagggtta      240

ctatgctccc tctttgccgc cgtctcctcc tcttgcccgc gcaggcaccc ctctggctgc      300

tcagtcctgc ctcagtgtca aaccagaaga gaagtaaaat tcaacaaaaa tttatgtgtg      360

gagttccttc ttaaaagaag aaaaaagtga ttatttagac tatggatcgg agcaaacgga      420

attcaattgc aggatttcct ccacgtgtgg agcgtcttga agagtttgaa ggaggtggtg      480

gaggagaagg aaatgtgagc caggtgggaa gagtttggcc atcttcgtat cgagctctta      540

taagtgcctt ttccagactg acgcgtttgg atgatttcac ctgtgaaaaa atagggtctg      600

gcttcttttc tgaagtgttc aaggtacgac accgagcttc tggtcaggtg atggctctta      660

agatgaacac attgagcagt aaccgggcaa acatgctgaa agaagtacag ctcatgaata      720

gactctccca tcccaacatc cttaggttca tgggtgtatg tgttcatcaa ggacaattgc      780

atgcacttac agagtatatc aactccggga acctggaaca gttgctagac agtaacctgc      840

atttgccttg gactgtgagg gtaaaactgg cctatgacat agcagtgggc ctcagctacc      900

ttcacttcaa aggcattttt catcgggacc tcacatctaa gaactgcctg ataaagaggg      960

atgagaatgg ttactctgca gtggtagctg actttggcct ggctgagaag atccccgatg     1020

tcagcatggg gagtgagaag ctggccgtgg tgggttcccc attctggatg gcacctgagg     1080

ttctccgaga tgagccctat aatgaaaagg cagatgtgtt ctcttatggt atcatcctct     1140

gcgagatcat cgcccgcatc caggccgatc cggactatct tccccgcaca gagaatttcg     1200

ggctggacta tgatgctttc cagcacatgg tgggagactg tcccccagat tttctgcaac     1260

ttactttcaa ctgctgtaac atggatccca aactgcgccc atcttttgtg gagattggga     1320

agaccctgga ggaaattctg agccgcctac aggaagaaga gcaggagagg gataggaagc     1380

tgcagcccac agccagggga ctcttggaga aagcacctgg ggtgaagcga ctaagctcac     1440

tggatgacaa gatcccccac aagtcaccat gcccaagacg taccatctgg ctgtctcgaa     1500

gccagtcaga tatcttttcc cgtaagcccc cacgtacagt gagtgtcttg gacccatact     1560

accggccacg agatggtgct gcccgcaccc ccaaagtcaa cccttttagt gctcgccagg     1620

acctcatggg gggcaagatc aagttttttg acctgcccag caagtctgtc atctctctgg     1680

tatttgacct ggatgcacca gggcccggaa ctatgcccct ggctgactgg caggagcccc     1740

tggccccacc tattcgccgg tggcgttcct tgcctggttc gcctgagttc ttgcatcaag     1800

aggcttgtcc atttgtgggc cgggaagaat cgctatctga tgggccccca ccacgcctaa     1860

gtagtctcaa gtacagagtt aaagagatcc caccattccg ggcatctgcc ctaccagctg     1920

ctcaagccca tgaggctatg gactgctcca ttctccagga agaaaatggt tttgggtcca     1980

ggccccaggg gaccagtcca tgccctgcgg gtgcttctga ggagatggag gtagaagaaa     2040

ggccagcagg ctcaactcca gccaccttct ccacctcagg cataggcctg caaacccagg     2100

gaaagcagga tgggtgaggg ggtttagtcc ctgcctcacc ttggggatgg accttcagct     2160

gaaaccatat ggccccctag gtgcacagcc ttgattcttc cctggagcct acagagcagg     2220

caggctaggc caagccaggc tcaacttctg ggctcccagt gcccattggc tgtgtatgac     2280

gggaggcagc agtgagaggc cttcctagtt agggccaaca gctgatacca agcctctgaa     2340

atccagcaag gaggtctgcc tcccaccaga ccctctccag tgtacttccc cagataggac     2400

cagaggatgt ctagttctag gctgagctgg caggcagcta ttaccccggt tctttcccca     2460

ccccaggtct gtctcttgcc ttttcttggg gcatataagc tactgagtgg aacatggagc     2520

tgatcaagag gccgtaatgg tcatggctgt ttcccagacc tgaatattgg ggtgcttctt     2580

gccagtattc taagacattt gagtaattgc tgtttgcact tactgcatgg tcagaccacg     2640

tcactacatt tctatgcaag gggacagcaa ggcagcgtgg tggtcatggc tcttagctaa     2700

cctattcaaa gaccttttcc tgttgattaa tctattttca tatttataaa ggagtcttaa     2760

tgttctgccc cataagactt tcaaccttgt ggttgggagt ggggctggtt ttgtaggccc     2820

tagggcctgc ttctatgtat ttatcaacat gtgatacatt caattggtta aatggtttat     2880

acagggactg atttgcttcc cttcctgcca tggctggagc tttgggaaca gtctgtcctt     2940

acagagctgc aataagaaat aaccaaagat gaagctggtc aaatattttc ataacttgct     3000

tctgttgatt tttttttttg taaaactttc ccaagacatt ttcagactta aaaataaagt     3060

cagtgttaca ggtg                                                       3074


<210> 1786
<211> 2530
<212> DNA
<213> Homo sapiens

<400> 1786
ctgtcctcct gcagaggtgg ctgtggtcct ggacctatgg gcccttccct tcccccaaca       60

ttgagccttg tgtgtctgca tggaggaggt tcccaaggtc tcatagtata agctgttcaa      120

gggtcagaga agcccccagg tcctgccttt tcctgtccct ttatgttggg gagttggggg      180

tgttacaggt atgctaaact ctttagctgc agtctatcta cccatgccag attcatcaag      240

atcctcgata gtgtcctgca ccacctggta cctgcctggg accacacact gggcaccttc      300

agtgagatta agcaagtgaa gcagttccta ctgctgtccc gccagcggcc aggcctggtg      360

gctcagtgcc tgcgtgactc tgagagcagc aagcccagct tcatgccacg cctatacatc      420

aaccgccgtc ttgccatgga acaccgtgcc tgcccctctc gagaccctgc ctgcaagaat      480

gcagtcttca cccaggtata tgaaggcctc aagccctctg acaaatatga aaagcccctg      540

gactacaggt ggcccatgcg ctatgaccag tggtgggagt gtaaatttat tgcagaaggc      600

atcattgacc aagggggtgg tttccgggac agcctggcag atatgtcaga agagctgtgc      660

cctagctcag cggatacccc cgtgcccctg cccttctttg tacgcacagc caaccagggc      720

aatggcactg gtgaggctcg ggacatgtat gtacccaacc cctcctgccg agactttgcc      780

aagtatgaat ggatcggaca gctgatgggg gctgcccttc ggggtaagga gttcctggtc      840

ctggccctgc ctggttttgt gtggaagcag ctttctggtg aggaggtgag ctggagcaag      900

gacttcccag ctgtggactc tgtgctggtg aagctcctgg aagtgatgga aggaatggac      960

aaggagacgt ttgagttcaa gtttgggaag gaactaacat tcaccactgt actgagtgac     1020

caacaggtgg tggagctgat ccctgggggt gcaggcatcg tcgtgggata tggggaccgt     1080

tctcgtttca tccaactggt ccagaaggca cggctagagg agagcaagga gcaggtggca     1140

gctatgcagg caggtctgct gaaggtggta ccacaggctg tgctggactt gctgacctgg     1200

caagagttgg agaagaaagt gtgtggggat ccagaggtca ctgtggatgc tctgcgcaag     1260

ctcacccggt ttgaggactt cgagccatct gactcgcggg tgcagtattt ctgggaggca     1320

ctgaacaact tcaccaacga ggaccggagc cgcttcctgc gctttgtcac gggccgcagt     1380

cgcctgccag cacggatcta catctaccca gacaagctgg gctacgagac cacagacgcg     1440

ctgcccgagt cttccacttg ctccagcacc ctcttcctgc cacactatgc cagtgccaag     1500

gtatgcgagg agaagctccg ctatgcggcc tacaactgcg tggccatcga cactgacatg     1560

agcccttggg aggagtgagg cgtgccgccg gctgtgggac cagcaagact gcacgtgtcc     1620

ctcttggcct tgcccagggc gaagacacct tccctgccct ggtttggctg acgtgctcag     1680

caaaacccca tgtgccctgc tcctgtgtgc agttggggta ggggcagctg gcatggtcag     1740

gtaacactag tggcccagcc ccgcagaccc acaagcccta cccgtgctgg ggcttgcttc     1800

ccgaggtatt tcacctctta agagggaatc ttccacaagc ccagcacaag ctgccaggcc     1860

tgagctactt gaagggggcc atctaggtcc ccaacccatg gactttgcct ccattttcag     1920

ctccgccttt tttctcctat tttctctctg gctttcttca gccatgactc acaactaaaa     1980

acataaaaca ctggaggtta gtggaggccc ctccccaagc agggagcctg ggatgggcag     2040

ggagtgatag ccaaactcct tggtcacctg ctccaagaag gaagcagtag ctgagcacct     2100

gccctcacat tctgctcttt tcccctctcc ctccatacca gagatgtggt gagctctgtt     2160

cttctaccaa cccagtctca acacacaaag tgccaccacc ttccctgact cagaacccac     2220

atccactcaa tgtgaactct actaccacga cctccccata ttcctcactt ctccatcacc     2280

tccagcctga ctccctgtct gccctttcac ccccaagatt ttgcacaggt taaggccagt     2340

tatggccttt ttgaaatctg taatagctcc cctttcccca actctaaagc ctagacctta     2400

aacctgttcc tagagctatg cacacccctg ccccagttta ccgttcctcc ctcagggcct     2460

ccgtgacact ccatgaaaag aagttcttgc ataccggaaa gttgaataaa tggatgaatt     2520

cattccttca                                                            2530


<210> 1787
<211> 1301
<212> DNA
<213> Homo sapiens

<400> 1787
atgatgcccc gcgagacctt tattctaacc gcaaggagta gcggagggga ggtcgtgatg       60

gcggcgccgg aggcggaggt tctgtcctca gccgcagtcc ctgatttgga gtggtatgag      120

aagtccgaag aaactcacgc ctcccagata gaactacttg agacaagctc tacgcaggaa      180

cctctcaacg cttcggaggc cttttgccca agagactgca tggtaccagt ggtgtttcct      240

gggcctgtga gccaggaagg ctgctgtcag tttacttgtg aacttctaaa gcatatcatg      300

tatcaacgcc agcagctccc tctgccctat gaacagctta agcactttta ccgaaaacct      360

tctccccagg cagaggagat gctgaagaag aaacctcggg ccaccactga ggtgagcagc      420

aggaaatgcc aacaagccct ggcagaactg gagagtgtcc tcagccacct ggaggacttc      480

tttgcacgga cactagtacc gcgagtgctg attctccttg ggggcaatgc cctaagcccc      540

aaggagttct atgaactcga cttgtctctg ctggccccct acagcgtgga ccagagcctg      600

agcacagcag cttgtttgcg ccgtctcttc cgagccatat tcatggctga tgcctttagc      660

gagcttcagg ctcctccact catgggcacc gtcgtcatgg cacagggaca ccgcaactgt      720

ggagaagatt ggtttcgacc caagctcaac tatcgagtgc ccagccgggg ccataaactg      780

actgtgaccc tgtcatgtgg cagaccttcc atccgaacca cggcttggga agactacatt      840

tggttccagg caccagtgac atttaaaggc ttccgcgagt gaatgagtgc ttcttaatcc      900

taaaaacaca atggctgaat tatctttctc catgtggcgc tgaatcaccc atctggtttg      960

gagctagagt tgcttcctgg tgagagagga agcaactctc cttctggttg tctgcctccc     1020

ctcagatttc ctgataggct gatggcatgt ggctgtgact gtgactgtaa tcattgctga     1080

acaacatctc tttgaatcaa aggttgattt tcccagaggg tgctgggtca ggcatttcta     1140

ttaggagttg gaaagcaaaa atgggtccat agacactcta tggaggtgtc cctttctgct     1200

ctttgctgtg tcctttcaga atttttacca ggaacataat gtggatgtga cttatgaact     1260

taaatataaa ataaatagat tcttattata ttttcctgaa a                         1301


<210> 1788
<211> 3610
<212> DNA
<213> Homo sapiens

<400> 1788
gctctgtccg cggtcgcgcc agctgttccc cgggcagggt cgcctctagg tgctcacctc       60

cgccacttcg ccatggcggg tcctggcccg ggcgcggtgc tggagtcccc ccggcagctg      120

ctgggccgcg tgcgcttctt ggcagaggca gcgcggagcc tccgcgccgg gcggccgctg      180

ccagcagcgc tggctttcgt gccgcgagag gtgctctaca agctttacaa ggacccagcg      240

ggaccgtcgc gcgtgcttct gccggtgtgg gaggcagagg gcctggggct gcgtgtgggc      300

gccgcaggcc cagcccccgg taccggctcc gggcccctcc gcgccgcccg cgacagcatt      360

gagctccggc gcggcgcctg cgtgcgcacc acgggcgagg agctgtgcaa tggccacggg      420

ctctgggtga agctgacaaa ggagcagctg gcagagcacc tgggcgactg cgggctgcag      480

gaaggctggc tgctggtgtg ccgcccggcg gagggcggag cccgcctggt acccatcgac      540

actcccaacc acctccagcg gcagcagcag ctctttggcg tggattatcg gccggtgctc      600

aggtgggaac aggtggtgga cctgacatac tcacatcgcc tgggatcgag acctcagccg      660

gcagaggcat acgcagaagc tgtacaaagg ctactctatg tacccccgac atggacctac      720

gagtgcgacg aggacctgat ccacttcttg tatgaccacc tgggcaagga ggatgagaac      780

ctgggtagcg tgaagcagta tgtggagagc atagacgttt cctcctacac ggaggagttc      840

aacgtgtcct gcctgacaga cagcaatgcc gatacctact gggagagcga tgggtcccag      900

tgccaacact gggtacggct tactatgaag aagggcacca ttgtcaagaa gctgctactc      960

acagtggata ccacagatga caactttatg ccaaagcggg tggtggtcta tgggggtgaa     1020

ggggacaacc tgaagaagct gagtgacgtg agcattgacg agaccctcat cggggatgtc     1080

tgtgtcctgg aggacatgac cgtccacctc ccgatcatcg agatccgcat cgtggagtgc     1140

cgagatgatg ggattgatgt tcgtctccga ggggtcaaga tcaagtcatc tagacagcgg     1200

gaactagggt tgaatgcaga cctgttccag ccaactagtc tggtgcgata tccacgccta     1260

gaaggcaccg accctgaagt actgtaccgc agagctgtcc tcctgcagag attcatcaag     1320

atcctcgata gtgtcctgca ccacctggta cctgcctggg accacacact gggcaccttc     1380

agtgagatta agcaagtgaa gcagttccta ctgctgtccc gccagcggcc aggcctggtg     1440

gctcagtgcc tgcgtgactc tgagagcagc aagcccagct tcatgccacg cctatacatc     1500

aaccgccgtc ttgccatgga acaccgtgcc tgcccctctc gagaccctgc ctgcaagaat     1560

gcagtcttca cccaggtata tgaaggcctc aagccctctg acaaatatga aaagcccctg     1620

gactacaggt ggcccatgcg ctatgaccag tggtgggagt gtaaatttat tgcagaaggc     1680

atcattgacc aagggggtgg tttccgggac agcctggcag atatgtcaga agagctgtgc     1740

cctagctcag cggatacccc cgtgcccctg cccttctttg tacgcacagc caaccagggc     1800

aatggcactg gtgaggctcg ggacatgtat gtacccaacc cctcctgccg agactttgcc     1860

aagtatgaat ggatcggaca gctgatgggg gctgcccttc ggggtaagga gttcctggtc     1920

ctggccctgc ctggttttgt gtggaagcag ctttctggtg aggaggtgag ctggagcaag     1980

gacttcccag ctgtggactc tgtgctggtg aagctcctgg aagtgatgga aggaatggac     2040

aaggagacgt ttgagttcaa gtttgggaag gaactaacat tcaccactgt actgagtgac     2100

caacaggtgg tggagctgat ccctgggggt gcaggcatcg tcgtgggata tggggaccgt     2160

tctcgtttca tccaactggt ccagaaggca cggctagagg agagcaagga gcaggtggca     2220

gctatgcagg caggtctgct gaaggtggta ccacaggctg tgctggactt gctgacctgg     2280

caagagttgg agaagaaagt gtgtggggat ccagaggtca ctgtggatgc tctgcgcaag     2340

ctcacccggt ttgaggactt cgagccatct gactcgcggg tgcagtattt ctgggaggca     2400

ctgaacaact tcaccaacga ggaccggagc cgcttcctgc gctttgtcac gggccgcagt     2460

cgcctgccag cacggatcta catctaccca gacaagctgg gctacgagac cacagacgcg     2520

ctgcccgagt cttccacttg ctccagcacc ctcttcctgc cacactatgc cagtgccaag     2580

gtatgcgagg agaagctccg ctatgcggcc tacaactgcg tggccatcga cactgacatg     2640

agcccttggg aggagtgagg cgtgccgccg gctgtgggac cagcaagact gcacgtgtcc     2700

ctcttggcct tgcccagggc gaagacacct tccctgccct ggtttggctg acgtgctcag     2760

caaaacccca tgtgccctgc tcctgtgtgc agttggggta ggggcagctg gcatggtcag     2820

gtaacactag tggcccagcc ccgcagaccc acaagcccta cccgtgctgg ggcttgcttc     2880

ccgaggtatt tcacctctta agagggaatc ttccacaagc ccagcacaag ctgccaggcc     2940

tgagctactt gaagggggcc atctaggtcc ccaacccatg gactttgcct ccattttcag     3000

ctccgccttt tttctcctat tttctctctg gctttcttca gccatgactc acaactaaaa     3060

acataaaaca ctggaggtta gtggaggccc ctccccaagc agggagcctg ggatgggcag     3120

ggagtgatag ccaaactcct tggtcacctg ctccaagaag gaagcagtag ctgagcacct     3180

gccctcacat tctgctcttt tcccctctcc ctccatacca gagatgtggt gagctctgtt     3240

cttctaccaa cccagtctca acacacaaag tgccaccacc ttccctgact cagaacccac     3300

atccactcaa tgtgaactct actaccacga cctccccata ttcctcactt ctccatcacc     3360

tccagcctga ctccctgtct gccctttcac ccccaagatt ttgcacaggt taaggccagt     3420

tatggccttt ttgaaatctg taatagctcc cctttcccca actctaaagc ctagacctta     3480

aacctgttcc tagagctatg cacacccctg ccccagttta ccgttcctcc ctcagggcct     3540

ccgtgacact ccatgaaaag aagttcttgc ataccggaaa gttgaataaa tggatgaatt     3600

cattccttca                                                            3610


<210> 1789
<211> 2315
<212> DNA
<213> Homo sapiens

<400> 1789
ggagttgcag tttgagagca gttccgggca gggaggcgcc tttgctgccc tcacagactt       60

ggcccctagc agtgcagaac tacaagtccc agggatccta gcgaccgtcc gtccgtagtc      120

aagttgccgg tggaattggc ccaggatgac agctggagaa tggagtcagt tttatccaag      180

tatgaagatc agattactat tttcactgac tacctagaag aatatccaga tacagatgag      240

ctggtatgga tcttagggaa gcagcatctc cttaaaacag aaaaatctaa gctgttgtct      300

gatataagtg ctcgtctatg gtttacatac agaaggaaat tttcaccaat tggtggaacg      360

ggcccttcat cagatgctgg ttggggatgt atgctacgct gtggacagat gatgctggct      420

caagccctta tctgtagaca cttgggaagg gactggagct gggagaaaca aaaagaacaa      480

cccaaagaat accaacgcat cctacagtgc ttcttagata gaaaagattg ttgctactct      540

atccatcaaa tggcacaaat gggtgtagga gaagggaaat caattggaga atggtttgga      600

ccaaatacag ttgcacaggt gttaaaaaaa cttgctttat ttgacgaatg gaattccttg      660

gctgtttatg tttcaatgga taacacagtg gtcattgaag atatcaaaaa aatgtgccgt      720

gtccttccct tgagtgctga cacagctggt gacaggcctc ccgattcttt aactgcttca      780

aaccagagta agggcacctc tgcctactgc tcagcctgga aacccctgct gctcattgtg      840

ccccttcgcc tgggcataaa ccaaatcaat cctgtctatg ttgatgcatt caaagagtgt      900

tttaagatgc cacagtcttt aggggcatta ggaggaaaac caaataacgc gtattatttc      960

ataggattct taggtgacga gctcatcttc ttggaccctc atacaaccca gacctttgtt     1020

gacactgaag agaatggaac ggttaatgac cagactttcc attgcctgca gtccccacag     1080

cgaatgaaca tcctaaacct ggatccttca gttgcattgg gatttttctg caaagaagaa     1140

aaagactttg ataactggtg tagccttgtt cagaaggaaa ttctaaagga gaatttaagg     1200

atgtttgaat tagttcagaa acatccatca cactggcctc cctttgtacc tccagccaag     1260

ccagaagtga caaccactgg ggcagaattc attgactcta ctgagcaact ggaggagttt     1320

gatctggagg aagattttga gattctgagt gtgtagaatc ctgggaactc aacttgaagg     1380

tctgtcttcc atctggcacc ataaaaacat gaacttattg cataaaactt ttctagtcag     1440

caagtgcctg atatgccaat agcatacaaa ctcaatagca atcatgactg agccaatcac     1500

tgtttctcag aaaaacaaaa caaaacaaaa caaatgacag taacccttcc ccggaaagaa     1560

atagaacaat catggagcct aggagcagag agatgaggag gagttcattg cttcccagct     1620

tgtgttatat ggctacagca agtcttcagc tgctgcaatg aggaaatggg catctggaag     1680

acaaacagca actctcagct tgcttcaaga accagcagat aagagatggt taagctgttc     1740

ttcacccttt cagatgtgac ctcttttgga ctaagcagca atctgttctc ttgctcaaat     1800

aataaagtga ctgaatcagg gaggaaaagg ttcttgttaa attatttgat tgtgtagttg     1860

aagtaattat aatttatatc aaaacgtttg tcaaagaaac gatgtcaaat atacacttct     1920

tgatctccct tctgtttgcg gggatcttac tatttgatgg gtcactgtcc ccattcttac     1980

tgatactttt gtcagatatc accctgtcct taaatcatga tcacttaaat caggggtcag     2040

caaacttttt ctgtaaaggg ccagacggga aatattttgg gctttgcagg ccatgcggcc     2100

tctgtcacat ctactcaact ctgctgttga catgcaaaag cagcaataga caatatgcgt     2160

gtaaatgagt gtggctgtaa tccaagaaaa ctttatttac aaaagcaggt ggagggctgg     2220

gtttggcctg caggctgtag cttgccaatc agtgacttaa attgttgatt tttgtttgat     2280

aaattaaaaa taaattgtgt ttgaagtata cccta                                2315


<210> 1790
<211> 2650
<212> DNA
<213> Homo sapiens

<400> 1790
atggacttac accgggcagc cttcaagatg gagaactcat cctaccttcc caaccctctg       60

gcatccccag cactgatggt cctggcatcc acggctgagg ccagccgtga tgcttccatc      120

ccttgtcagc agccacgacc ctttggtgta cctgtctcag ttgacaagga cgtgcatatt      180

cctttcacca acggttccta tacctttgcc tctatgtacc atcggcaagg tggggtgcca      240

ggcacttttg ccaatcgtga tttcccccct tctctactac acctccaccc tcaatttgct      300

cccccaaatc tagattgcac cccaatcagt atgctgaatc atagtggtgt gggggctttc      360

cggccctttg cctccaccga ggaccgggag agctatcagt cagcctttac gccggccaag      420

cgacttaaga actgccatga cacagagtct ccccacttgc gcttctcaga tgcagatggc      480

aaggaatatg actttgggac acagctgcca tctagctccc ccggttcact aaaggttgat      540

gacactggga agaagatttt tgctgtctct ggcctcattt ctgatcggga agcctcatct      600

agcccagagg atcggaatga cagatgtaag aagaaagcag cggcattgtt cgacagccag      660

gccccaattt gccccatctg ccaggtcctg ctgaggccca gtgagctgca ggagcatatg      720

gagcaggaac tggagcagct agcccaactg ccctcgagca agaattccct tctgaaggat      780

gccatggctc caggcacccc aaagtccctc ctgttgtctg cttccatcaa gagggaagga      840

gagtctccaa cggcatcacc ccactcatct gccaccgatg acctccacca ttcagacaga      900

taccagacct ttctgcgagt acgagccaac cggcagaccc gactgaatgc tcggattggg      960

aaaatgaaac ggaggaagca agatgaaggg cagagggaag gctcctgcat ggctgaggat     1020

gatgctgtgg acatcgagca tgagaacaac aaccgctttg aggagtatga gtggtgtgga     1080

cagaagcgga tacgggccac cactctcctg gaaggtggct tccgaggctc tggcttcatc     1140

atgtgcagcg gcaaagagaa cccggacagt gatgctgact tggatgtgga tggggatgac     1200

actctggagt atgggaagcc acaatacaca gaggctgatg tcatcccctg cacaggcgag     1260

gagcctggtg aagccaagga gagagaggca cttcggggcg cagtcctaaa tggcggccct     1320

cccagcacgc gcatcacacc tgagttctct aaatgggcca gtgatgagat gccatccacc     1380

agcaatggtg aaagcagcaa gcaggaggcc atgcagaaga cctgcaagaa cagcgacatc     1440

gagaaaatca ccgaagattc agctgtgacc acgtttgagg ctctgaaggc tcgggtcaga     1500

gaacttgaac ggcagctatc tcgtggggac cgttacaaat gcctcatctg catggactcg     1560

tactcgatgc ccctaacgtc catccagtgt tggcacgtgc actgcgagga gtgctggctg     1620

cggaccctgg gtgccaagaa gctctgccct cagtgcaaca cgatcacagc gcccggagac     1680

ctgcggagga tctacttgtg agctatctgc cccaggcagg cctcgcctcc agcagcccca     1740

cctgccccca gcctctgtga cagtgaccgt ctccctttgt acatacttgc acacaggttc     1800

cccatgtaca tacatgcaca tactcaaaca tgcgtacaca cacacacatt tacacacgca     1860

ggactctgga gccagagtag aggctgtggc ccaggcacta cctgctggct cccacctatg     1920

gtttgggggc catacctgtt ccagctctgt tcccagggtg gggcagggag gtgggggttg     1980

ggggagtagt ggggcacggc tcctaagatc cagcccccat actgacagac ggacagacag     2040

acatgcaaac accagactga agcacatgta atatagaccg tgtatgttta caatgttgtg     2100

tataaatggg acaactcctc gccctctacc tgtcccctcc ccctttggtt gtatgatttt     2160

cttctttttt aagaacccct ggaagcagcg cctccttcag ggttggctgg gagctcggcc     2220

catccacctc ttggggtacc tgcctctctc tctcctgtgg tgtcccttcc ctctcccatg     2280

tgctcggtgt tcagtggtgt atatttcttc tcccagacat ggggcacacg ccccaaggga     2340

catgatcctc tccttagtct tagctcatgg ggctctttat aaggagttgg ggggtagagg     2400

caggaaatgg gaaccgagct gaagcagagg ctgagttagg gggctagagg acagtgctcc     2460

tggccaccca gcctctgctg agaaccattc ctgggattag agctgccttt cccagggaaa     2520

aagtgtcgtc tccccgaccc tcccgtgggc cctgtggtgt gatgctgtgt ctgtatattc     2580

tatacaaagg tacttgtcct ttccctttgt aaactacatt tgacatggat taaaccagta     2640

taaacagttg                                                            2650


<210> 1791
<211> 1878
<212> DNA
<213> Homo sapiens

<400> 1791
atgccgagag cccggagcgg ccggaggagc agaggggccg gcgggaggga ggaaaccttt       60

ctgcgagtac gagccaaccg gcagacccga ctgaatgctc ggattgggaa aatgaaacgg      120

aggaagcaag atgaagggca ggtatgtccc ctgtgcaacc gccccctggc aggatcggag      180

caggagatga gtaggcatgt ggagcattgc ctttctaaga gggaaggctc ctgcatggct      240

gaggatgatg ctgtggacat cgagcatgag aacaacaacc gctttgagga gtatgagtgg      300

tgtggacaga agcggatacg ggccaccact ctcctggaag gtggcttccg aggctctggc      360

ttcatcatgt gcagcggcaa agagaacccg gacagtgatg ctgacttgga tgtggatggg      420

gatgacactc tggagtatgg gaagccacaa tacacagagg ctgatgtcat cccctgcaca      480

ggcgaggagc ctggtgaagc caaggagaga gaggcacttc ggggcgcagt cctaaatggc      540

ggccctccca gcacgcgcat cacacctgag ttctctaaat gggccagtga tgcagagatg      600

ccatccacca gcaatggtga aagcagcaag caggaggcca tgcagaagac ctgcaagaac      660

agcgacatcg agaaaatcac cgaagattca gctgtgacca cgtttgaggc tctgaaggct      720

cgggtcagag aacttgaacg gcagctatct cgtggggacc gttacaaatg cctcatctgc      780

atggactcgt actcgatgcc cctaacgtcc atccagtgtt ggcacgtgca ctgcgaggag      840

tgctggctgc ggaccctggg tgccaagaag ctctgccctc agtgcaacac gatcacagcg      900

cccggagacc tgcggaggat ctacttgtga gctatctgcc ccaggcaggc ctcgcctcca      960

gcagccccac ctgcccccag cctctgtgac agtgaccgtc tccctttgta catacttgca     1020

cacaggttcc ccatgtacat acatgcacat actcaaacat gcgtacacac acacacattt     1080

acacacgcag gactctggag ccagagtaga ggctgtggcc caggcactac ctgctggctc     1140

ccacctatgg tttgggggcc atacctgttc cagctctgtt cccagggtgg ggcagggagg     1200

tgggggttgg gggagtagtg gggcacggct cctaagatcc agcccccata ctgacagacg     1260

gacagacaga catgcaaaca ccagactgaa gcacatgtaa tatagaccgt gtatgtttac     1320

aatgttgtgt ataaatggga caactcctcg ccctctacct gtcccctccc cctttggttg     1380

tatgattttc ttctttttta agaacccctg gaagcagcgc ctccttcagg gttggctggg     1440

agctcggccc atccacctct tggggtacct gcctctctct ctcctgtggt gtcccttccc     1500

tctcccatgt gctcggtgtt cagtggtgta tatttcttct cccagacatg gggcacacgc     1560

cccaagggac atgatcctct ccttagtctt agctcatggg gctctttata aggagttggg     1620

gggtagaggc aggaaatggg aaccgagctg aagcagaggc tgagttaggg ggctagagga     1680

cagtgctcct ggccacccag cctctgctga gaaccattcc tgggattaga gctgcctttc     1740

ccagggaaaa agtgtcgtct ccccgaccct cccgtgggcc ctgtggtgtg atgctgtgtc     1800

tgtatattct atacaaaggt acttgtcctt tccctttgta aactacattt gacatggatt     1860

aaaccagtat aaacagtt                                                   1878


<210> 1792
<211> 2199
<212> DNA
<213> Homo sapiens

<400> 1792
cgcctttgct gccctcacag acttggcccc tagcagtgca gaactacaag tcccagggat       60

cctagcgacc gtccgtccgt agtcaagttg ccggtggaat tggcccagga tgacagctgg      120

agaatggagt cagttttatc caagtatgaa gatcagatta ctattttcac tgactaccta      180

gaagaatatc cagatacaga tgagctggta tggatcttag ggaagcagca tctccttaaa      240

acaggtggaa cgggcccttc atcagatgct ggttggggat gtatgctacg ctgtggacag      300

atgatgctgg ctcaagccct tatctgtaga cacttgggaa gggactggag ctgggagaaa      360

caaaaagaac aacccaaaga ataccaacgc atcctacagt gcttcttaga tagaaaagat      420

tgttgctact ctatccatca aatggcacaa atgggtgtag gagaagggaa atcaattgga      480

gaatggtttg gaccaaatac agttgcacag gtgttaaaaa aacttgcttt atttgacgaa      540

tggaattcct tggctgttta tgtttcaatg gataacacag tggtcattga agatatcaaa      600

aaaatgtgcc gtgtccttcc cttgagtgct gacacagctg gtgacaggcc tcccgattct      660

ttaactgctt caaaccagag taagggcacc tctgcctact gctcagcctg gaaacccctg      720

ctgctcattg tgccccttcg cctgggcata aaccaaatca atcctgtcta tgttgatgca      780

ttcaaagagt gttttaagat gccacagtct ttaggggcat taggaggaaa accaaataac      840

gcgtattatt tcataggatt cttaggtgac gagctcatct tcttggaccc tcatacaacc      900

cagacctttg ttgacactga agagaatgga acggttaatg accagacttt ccattgcctg      960

cagtccccac agcgaatgaa catcctaaac ctggatcctt cagttgcatt gggatttttc     1020

tgcaaagaag aaaaagactt tgataactgg tgtagccttg ttcagaagga aattctaaag     1080

gagaatttaa ggatgtttga attagttcag aaacatccat cacactggcc tccctttgta     1140

cctccagcca agccagaagt gacaaccact ggggcagaat tcattgactc tactgagcaa     1200

ctggaggagt ttgatctgga ggaagatttt gagattctga gtgtgtagaa tcctgggaac     1260

tcaacttgaa ggtctgtctt ccatctggca ccataaaaac atgaacttat tgcataaaac     1320

ttttctagtc agcaagtgcc tgatatgcca atagcataca aactcaatag caatcatgac     1380

tgagccaatc actgtttctc agaaaaacaa aacaaaacaa aacaaatgac agtaaccctt     1440

ccccggaaag aaatagaaca atcatggagc ctaggagcag agagatgagg aggagttcat     1500

tgcttcccag cttgtgttat atggctacag caagtcttca gctgctgcaa tgaggaaatg     1560

ggcatctgga agacaaacag caactctcag cttgcttcaa gaaccagcag ataagagatg     1620

gttaagctgt tcttcaccct ttcagatgtg acctcttttg gactaagcag caatctgttc     1680

tcttgctcaa ataataaagt gactgaatca gggaggaaaa ggttcttgtt aaattatttg     1740

attgtgtagt tgaagtaatt ataatttata tcaaaacgtt tgtcaaagaa acgatgtcaa     1800

atatacactt cttgatctcc cttctgtttg cggggatctt actatttgat gggtcactgt     1860

ccccattctt actgatactt ttgtcagata tcaccctgtc cttaaatcat gatcacttaa     1920

atcaggggtc agcaaacttt ttctgtaaag ggccagacgg gaaatatttt gggctttgca     1980

ggccatgcgg cctctgtcac atctactcaa ctctgctgtt gacatgcaaa agcagcaata     2040

gacaatatgc gtgtaaatga gtgtggctgt aatccaagaa aactttattt acaaaagcag     2100

gtggagggct gggtttggcc tgcaggctgt agcttgccaa tcagtgactt aaattgttga     2160

tttttgtttg ataaattaaa aataaattgt gtttgaagt                            2199


<210> 1793
<211> 779
<212> DNA
<213> Homo sapiens

<400> 1793
aagtagttgc tgggacagcg aaatggaggg gtgtgtgtct aacctaatgg tctgcaacct       60

ggcctacagc gggaagctgg aagagttgaa ggagagtatt ctggccgata aatccctggc      120

tactagaact gaccaggaca gcagaactgc attgcactgg gcatgctcag ctggacatac      180

agaaattgtt gaatttttgt tgcaacttgg agtgccagtg aatgataaag acgatgcagc      240

ttcgaaaaac aggcatgaga tcgctgtcat gttactggaa ggcggggcta atccagatgc      300

taaggaccat tatgaggcta cagcaatgca ccgggcagca gccaagggta acttgaagat      360

gattcatatc cttctgtact acaaagcatc cacaaacatc caagacactg agggtaacac      420

tcctctacac ttagcctgtg atgaggagag agtggaagaa gcaaaactgc tggtgtccca      480

aggagcaagt atttacattg agaataaaga agaaaagaca cccctgcaag tggccaaagg      540

tggcctgggt ttaatactca agagaatggt ggaaggttaa acagcttgga tttattctta      600

ctttgtatgt tgtgttgttg tccccagtgt cctacaaact aatgtatttg tgcacaagac      660

atcatctatg aatgatgaag ttttctcacc ttcaaagtct tataaacatg ttgactcttg      720

ttcctgctga gttacttgtt cgaagcttac agcttgtttt ccaggcatcg aataactgt       779


<210> 1794
<211> 878
<212> DNA
<213> Homo sapiens

<400> 1794
aagtagttgc tgggacagcg aaatggaggg gtgtgtgtct aacctaatgg tctgcaacct       60

ggcctacagc gggaagctgg aagagttgaa ggagagtatt ctggccgata aatccctggc      120

tactagaact gaccaggaca gcagaactgc attgcactgg gcatgctcag ctggacatac      180

agaaattgtt gaatttttgt tgcaacttgg agtgccagtg aatgataaag acgatgcagc      240

ttcgaaaaac aggcatgaga tcgctgtcat gttactggaa ggcggggcta atccagatgc      300

taaggaccat tatgaggcta cagcaatgca ccgggcagca gccaaggaca cttagcctgt      360

gatgaggaga gagtggaaga agcaaaactg ctggtgtccc aaggagcaag tatttacatt      420

gagaataaag aagaaaagac acccctgcaa gtggccaaag gtggcctggg tttaatactc      480

aagagaatgg tggaaggtta aacagcttgg atttattctt actttgtatg ttgtgttgtt      540

gtccccagtg tcctacaaac taatgtattt gtgcacaaga catcatctat gaatgatgaa      600

gttttctcac cttcaaagtc ttataaacat gttgactctt gttcctgctg agttacttgt      660

tcgaagctta cagcttgttt tccaggcatc gaataactgt tgagattgtt ctactgttgt      720

cgtatattct tctatattga attctggtta atttggagta actaattctg tggctgttgt      780

gagtcttcag caccctccca tgtaccttat atccctctct gaaacagaac agctccaata      840

gcaacaagct agttgttctg ccagatgttt ctatgtgg                              878


<210> 1795
<211> 1201
<212> DNA
<213> Homo sapiens

<400> 1795
cttcacttca tctcttcccc ctcacccaca gcagcactgg ctccttggtg tgtgtatggc       60

cgaagagggc ctggacacag ggtaccctgg gtgaaagatg gggctgaggc tccaaggctc      120

ctgctgtact tttcttcttt ttgagcagga gctggagggt gcctcaggaa tacaggaggg      180

acatgggagg agggctgttg ggctgagggc tccctgtctg gctgccatct cttcttcctg      240

ctaccctgtt cacaaactgg gggtgcttaa ctccctctgt gaatcaacat gaagtcactg      300

ctggcaacct agagcctgcg agacatctgg ccctgatgga gggggaggga aaggtgtctg      360

gaacccaaac tttctgcatt atgatcccca cccccaacct ctctcacgta cacctgcgtg      420

ttcatgtaca catacatgta catagcatcc cttgagctgt cctcacctga cctactgaac      480

tctgaggtgg tccgggtccc ccagagatgg ctgggtagct ggttttggca gcctctacct      540

gtgaggtgtg aagttggggg ctggggtggc aggtgagtgg gggggatggt ccttggagct      600

ggctggggct gggcttacca gctccacctc ctgcaggctc tgaagcggaa gccagatttg      660

ttcctgtgtg aacgattgga tgtcaaagct gtgttccagt gtgctgtgct ggccctcaag      720

ttccctgagg cacctactgt caaggcctcc tgtggcttct ttacagagct gctgcctcgg      780

tgtggggaag tagagtctgt gggaaaggtg gtacaggaag acggtcgtat gctgctcata      840

gcagtgctgg aggccattgg gggccaggcc tcccgcagcc tcatggactg ctttgccgat      900

atcctgttcg ccctgaacaa gcactgcttc agcctcctga gcatgtggat caaggaggcc      960

ctgcagccac ctggtttccc ctctgcccgc ctcagccctg aacagaagga taccttcagc     1020

cagcagatcc ttcgcgagcg agtgaacaag aggcgggtga aggagatggt gaaggagttc     1080

acactgctgt gccggggtct ccatggcaca gattacacag ctgactactg aggggtgccc     1140

ccatcccatc caccccttct cttcatcctt ccctattccc aaagagtaaa cctggaccct     1200

c                                                                     1201


<210> 1796
<211> 3894
<212> DNA
<213> Homo sapiens

<400> 1796
cggccggcct ggcttgtctt gtcagtcact ggggcggagg cagcggctgt agcggggctg       60

tagccgggcg ttgagcacag cgcgggccag gccgaacgga agggacctgc cacagcccct      120

caactccacg gactcttcgc cctagactag cggagctgca tctccgcgct tcgttggacg      180

cctccgtaac cacgaagggc tctctctctc ccgtgaccct ccagccccat gacctgttca      240

tagcagccga gagctcaccc aggcgggggt gttgtgggta caggccatcg accctgtgac      300

ccctcaagag ccagggactc ggtttccccc gcaggcctcc ctcccctgtg actccctcca      360

cacagattct ggggacagag ctgttacctg ccactaggat ccccgcctga gagctcctca      420

ctgacggctc cctcctcgga gtccccttca ttgggtctcc taagagcacc aattttggtc      480

tctggcaagc ctcccacccc caaacgaggt ggggaggcct cggcagccat gcccgccctg      540

ggccccccct caccccacca ctccctgggc acccaagccg gggtctagca gggggccagc      600

agccaagggg ctggggcagg agacagatca gggcccacct ccctgccagg gagggagcaa      660

agatggagcg gcgggaggag cagccggggg ctgcaggggc tggagcagca ccagccttgg      720

acttcactgt ggagaacgtg gagaaggcgc tgcaccagct ctactatgat cccaacattg      780

agaataagaa cctggctcag aagtggctga tgcaggccca ggtctcccca caggcctggc      840

acttcagctg gcagctactg cagcccgaca aggtaccaga gatccagtac tttggggcca      900

gtgctcttca catcaagatc tctcgctact ggagtgacat ccccactgac cagtatgaaa      960

gcctaaaggc acagctcttc acccagatca cccgctttgc cagtggctcc aagattgtac     1020

tgactcggct gtgcgtggca ctggcctcac tggctctcag catgatgcct gacgcttggc     1080

catgtgctgt ggcagatatg gtacgactct tccaggctga ggactcacca gtggatgggc     1140

agggccgctg cctagccctg ttagagctgc tgacagtgct gcctgaggag ttccagacca     1200

gtcgcctacc ccagtaccgc aaaggcctgg tgcggaccag cctggcggtg gaatgtgggg     1260

ctgtcttccc gctgctggag cagctgctac agcagcccag ctcacccagc tgtgtgcgtc     1320

agaaggtgct caagtgtttc tccagctggg tgcagctgga ggtgccgctg caggactgtg     1380

aggcgctcat tcaggctgcc tttgctgctc tgcaggactc ggagctcttc gacagcagtg     1440

tggaggccat tgtgaatgcc atctcacagc ctgatgccca gaggtacgtg aacacactcc     1500

tgaaactcat cccgctggtg ctgggtctgc aggaacaact gcggcaggca gtgcagaatg     1560

gggacatgga gacctcccat ggcatctgtc gcatcgctgt ggccctgggc gagaaccact     1620

cccgggcctt gctggaccaa gtagagcact ggcagagttt cctggcactc gtcaacatga     1680

ttatgttctg cacaggcatc cctggccact atcctgtcaa tgagaccacc agctccctaa     1740

ccctcacctt ctggtacaca ctgcaggatg atattctatc ctttgaggca gagaagcagg     1800

ctgtatacca gcaggtgtac cggccagtct acttccagct ggtggatgtg cttctgcaca     1860

aggcccagtt cccttctgat gaggaatatg gattctggtc ctcagacgag aaggagcagt     1920

tccgaattta cagggtggac atctcagaca cgctcatgta tgtctatgag atgttggggg     1980

ccgagctgct cagcaacctc tatgacaagc tgggtcgttt gctcaccagc tcagaggagc     2040

cctactcctg gcagcacaca gaggccctcc tctacggctt ccaatccatc gcagagacca     2100

ttgacgtcaa ctattctgat gtggtgcctg ggctcattgg cctcatccca cggatcagca     2160

tcagcaacgt gcagctggca gacactgtca tgttcaccat tggagctctg tctgaatggc     2220

tggctgacca ccccgtcatg atcaacagtg ttctgccctt ggtactgcat gccctaggca     2280

atcctgagct gtctgtctct tctgtgtcca ccctcaagaa gatctgccga gagtgcaagt     2340

atgacctgcc tccctatgct gccaacattg tggctgtgtc ccaggatgtg ctgatgaaac     2400

agatccacaa gacaagccag tgcatgtggc tgatgcaggc gctgggcttc ctgctgtcag     2460

ctcttcaagt ggaggagatc cttaagaacc tgcactcgct tatctcaccc tatatccagc     2520

aactggagaa gctggcagag gagataccca atccctccaa caagctggcc attgttcaca     2580

tcttggggct tctctccaac ctcttcacca cactggacat cagtcatcat gaggatgatc     2640

atgaaggccc tgagcttcgg aagctgccag tgccacaggg acccaacccc gtggtggtgg     2700

tgctgcagca ggtcttccag cttatccaga aggtgctgag caaatggttg aatgatgccc     2760

aggttgtgga ggcggtgtgc gctatctttg agaagtctgt taagacgctg ctggatgact     2820

ttgcccccat ggtgccacag ctgtgtgaga tgctgggtcg gatgtacagc accatccccc     2880

aggcctctgc tcttgacctc actcgacagc tggtccacat ctttgctcat gagcctgccc     2940

actttccccc aattgaggcc ctcttcctgc tcgtcacctc cgtcacactc actctcttcc     3000

agcaagggcc cagggatcat cctgatattg ttgattcatt tatgcaactc ctggcacagg     3060

ctctgaagcg gaagccagat ttgttcctgt gtgaacgatt ggatgtcaaa gctgtgttcc     3120

agtgtgctgt gctggccctc aagttccctg aggcacctac tgtcaaggcc tcctgtggct     3180

tctttacaga gctgctgcct cggtgtgggg aagtagagtc tgtgggaaag gtggtacagg     3240

aagacggtcg tatgctgctc atagcagtgc tggaggccat tgggggccag gcctcccgca     3300

gcctcatgga ctgctttgcc gatatcctgt tcgccctgaa caagcactgc ttcagcctcc     3360

tgagcatgtg gatcaaggag gccctgcagc cacctggttt cccctctgcc cgcctcagcc     3420

ctgaacagaa ggataccttc agccagcaga tccttcgcga gcgagtgaac aagaggcggg     3480

tgaaggagat ggtgaaggag ttcacactgc tgtgccgggg tctccatggc acagattaca     3540

cagctgacta ctgaggggtg cccccatccc atccacccct tctcttcatc cttccctatt     3600

cccaaagagt aaacctggac cctcactgct gtctctgcct cctttctgct gtcaccacca     3660

cctaactgaa agcctgggtc cagaaggcct gggggaagga tgggaggatg cttggaccca     3720

ggccttggga gggaatggtg ggaacatcct ctagctccca ggttggaaga gatactactg     3780

tagccaagcc acctaggctg gagcccttca gaatactgtc attgtccttg gggcggggtg     3840

gttgcagtag tgtcatcaac ccccccatcc ccattaaatt aatcccaaca tgca           3894


<210> 1797
<211> 2907
<212> DNA
<213> Homo sapiens

<400> 1797
atgaggttgc tgaggcatac agagagtgag cagtggtttc atcgcttccc tctgtgtcct       60

tctctcactt tctgggcccc agtggccatg tggccacaga cacactgtgt aggtggtcgg      120

tcatcaggct taacgaaatg gacatattca ttttcagcat cactccaaga tgggtcgttc      180

ccctatgact ctgtcccttg gcagcagaac accaaccagc ctcccggctc cctttccgtg      240

gtcaccacgg tttggggagt aaccaacaca tcccagagcc aggctgacgt tctcatcccc      300

cacgccacct gccgcccagg cccgctcctt atcaccgctt gggaacccta tggccaatgc      360

caacaacccc atgaatccag gcggcaaccc catggcgtcg ggcatgacca ccagcaaccc      420

aggcctcaac tccccacagt ttgcggggca gcagcagcag ttctcagcca aggctggccc      480

cgctcagccc tacatccagc agagcatgta tggccggccc aactaccccg gcagcggggg      540

ctttggggcc agcccgcggc agccgctgca gcagcggcag tggcagcagc agcagccaca      600

gctacagcca cagccacggc cactgtggca gccctgcagg agacacagaa caaggatata      660

aaccagtatg gaccggcccc agtgctgctc cctgaccttc tgaaggatgg gttaggggat      720

gaggagaggg gagcccccat aggaatgcag aacagcatga accccgcgag catggcggct      780

ggcatgacgc cctcggggat gagcggccct cccatgggca tgaaccagcc ccggccgccc      840

ggcatcagcc cctttggcac acacgggcag cggatgcccc agcagaccta cccgggcccc      900

cggccccagt cccttcctat tcagaacata aagaggccat accctggaga gcccaactat      960

ggaaaccagc aatatggacc aaacagccag ttccccaccc agccaggcca gtacccagcc     1020

cccaaccccc cgaggccact cacctccccc aactacccag gacagaggat gcccagccag     1080

ccgagctccg ggcagtaccc gccccccacg gtcaacatgg ggcagtatta caagccagaa     1140

cagtttaatg gacaaaataa cacgttctcg ggaagcagct acagtaacta cagccaaggg     1200

aatgtcaaca ggcctcccag gccggttcct gtggcaaatt acccccactc acctgttcca     1260

gggaacccca caccccccat gacccctggg agcagcatcc ctccatacct gtcccccagc     1320

caagacgtca aaccaccctt cccgcctgac atcaagccaa atatgagcgc tctgccacca     1380

cccccagacc acaatgacga gctgcggctc acattccctg tgcgggatgg cgtggtgctg     1440

gagcccttcc gcctggagca caacctggcg gtcagcaacc atgtgttcca cctgcggccc     1500

acggtccacc agacgctgat gtggtctgac ctggagctgc agttcaagtg ctaccaccac     1560

gaggaccggc agatgaacac caactggccc gcctcggtgc aggtcagcgt gaacgccacg     1620

cccctcacca ttgagcgcgg cgacaacaag acctcccaca agcccctgca cctgaagcac     1680

gtgtgccagc cgggccgcaa caccatccag atcaccgtca cggcctgctg ctgctcccac     1740

ctcttcgtgc tgcagctggt acaccggccc tccgtccgct ctgtgctgca aggactcctc     1800

aagaagcgcc tcctgcccgc agagcactgt atcacgaaaa agcggaattt cagcagcgtg     1860

gctgcctcct cgggcaacac gaccctcaac ggggaggatg gggtggagca gacggccatc     1920

aaggtgtctc tgaagtgccc catcacattc cggcgcatcc agctgcctgc tcgaggacac     1980

gattgcaagc atgtgcagtg ctttgatctg gagtcatacc tgcagctgaa ttgcgagaga     2040

gggacctgga ggtgtcctgt gtgcaaaacc gctctgctgg agggcctgga ggtggatcag     2100

tacatgtggg gaatcctgaa tgccatccac tccgagtttg aagaggtcac catcgatccc     2160

acgtgcagct ggcggccggt gcccatcaag tcggacttac acatcaagga cgaccctgat     2220

ggcatcccct ccaagcggtt caagaccatg agtcccagcc agatgatcat gcccaatgtc     2280

atggagatga tcgcagccct gggccccggc ccgtccccct atcccctccc gcctccccca     2340

gggggcacca actccaacga ctacagcagc caaaacaact accaaggcca tggcaacttt     2400

gacttccccc acgggaaccc tggagggaca tccatgaatg acttcatgca cgggcccccc     2460

cagctctccc accccccgga catgcccaac aacatggccg ccctcgagaa acccctcagc     2520

caccccatgc aggaaactat gccacacgct ggcagctctg accagcccca cccctccata     2580

caacaaggtt tgcacgtacc acaccccagc agccagtcag ggcctccatt acatcacagt     2640

ggggctcctc ctcctcctcc ttcccagcct ccccggcagc cgccacaggc cgctcccagc     2700

agccatccac acagcgacct gacctttaac ccctcctcag ccttagaggg tcaggccgga     2760

gcgcagggag cgtccgacat gccggagcct tcgctggatc tccttcccga actcacaaat     2820

cctgacgagc tcctgtctta tctggacccc cccgacctgc cgagcaatag taacgatgac     2880

ctcctgtctc tatttgagaa caactga                                         2907


<210> 1798
<211> 607
<212> DNA
<213> Homo sapiens

<400> 1798
ccaagatggc gatggagatg aggcttccag tggctcgcaa gcctcttagc gagagactgg       60

gccgcgacac taagaaacat ctagtggtgc cgggggatac aatcactacg gacacaggat      120

tcatgcgggg ccatggaacg tatatgggag aagagaagct cattgcatct gttgctggct      180

ctgtggagag agtaaacaag ttgatctgtg tgaaagcttt gaaaaccaga tacattggtg      240

aagtaggaga catcgtagtg ggacgaatca cagaggttca acagaagagg tggaaggtgg      300

agaccaactc caggctggat tcggtcttgc tgctctcgtc catgaacctt cctggaggag      360

agctgaggag aagatctgca gaagatgagc ttgcaatgag aggtttctta caggaagggg      420

accttatcag tgctgaggtc caggcagtgt tctctgacgg agctgtctct ttgcacacga      480

ggagcctgaa atatggaaaa acccactttc atgatttgcc atgtggtgcc tcagtgattc      540

tcggtaacaa cggcttcatc tggatttacc caacacctga gcacaaagaa gaggaagcag      600

ggggctt                                                                607


<210> 1799
<211> 1885
<212> DNA
<213> Homo sapiens

<400> 1799
gccaagatgg cgatggagat gaggcttcca gtggctcgca agcctcttag cgagagactg       60

ggccgcgaca ctaagaaaca tctagtggtg ccgggggata caatcactac ggacacagga      120

ttcatgcggg gccatggaac gtatatggga gaagagaagc tcattgcatc tgttgctggc      180

tctgtggaga gagtaaacaa gttgatctgt gtgaaagctt tgaaaaccag atacattggt      240

gaagtaggag acatcgtagt gggacgaatc acagagagga gaagatctgc agaagatgag      300

cttgcaatga gaggtttctt acaggaaggg gaccttatca gtgctgaggt ccaggcagtg      360

ttctctgacg gagctgtctc tttgcacacg aggagcctga aatatggaaa actaggtcag      420

ggggttttgg tccaggtttc cccctccctg gtgaaacggc agaagaccca ctttcatgat      480

ttgccatgtg gtgcctcagt gattctcggt aacaacggct tcatctggat ttacccaaca      540

cctgagcaca aagaagagga agcagggggc ttcattgcaa acctggagcc tgtctctctt      600

gctgatcgag aggtgatatc ccggcttcgg aactgcatca tctcgctggt aactcagagg      660

atgatgctgt atgataccag catcctgtac tgctatgaag catcccttcc acatcagatc      720

aaagacatct taaagccaga aataatggag gagattgtga tggaaacacg ccagaggctt      780

ttggaacagg agggataagg aggtgctcca gaagcacggg actgtggacc ttgcaggagt      840

gaagactgtg atgtgtggtc cccatatgtg gctcagcaaa gactcgagag atcatccctt      900

tgtctgcatt gacggccctg tgacggcctc cagcccacag gcctgctttc tcctgtccta      960

acaccaagcc tgggtggcag atgaacagtg cttccttggg ttgccagctg agtcccggta     1020

ttagggaata gtttcagctc tttcaaagtg cacagtgtta cagtcgaatg ggctcccatc     1080

ctggaataat atggagaatc ctttgtcttc cactcactgt cattcacaag gcacagtgcc     1140

ccatgaaatt gccccaatag aaaacatggc atccctgacc tccaaatggt ctgttttggc     1200

ctccattcct atatccttta aatgactgag aatgcagctg gtaaagttgg aagaataaag     1260

ttaaccaagc aggccaggca cggtggctca cgcctataat cccagcactt agggaggcca     1320

aggcgggcag atcacctgag gtcaatagtt cgagaccagc ctggccaaca aggtgaaacc     1380

ccatctctac taaaaataca aaaaattagc caggtgtggt ggtgtgcacc tgtagtccca     1440

gctatttggg aggctgaggt gggagaatca cttgaacctg ggaggcggag gttgcagtga     1500

gctgaaatcg cgtaccacac tccagcctgg gtgacagagc gagactgtgt ttcaaagaaa     1560

aaaaaaaaca agcagccttt tgcttggttg gaatctgatt ttctgttgcg tgttccttgt     1620

agccatagat gtgattatgt ccacaccggg ctgccttaat ctgtcctgct tggagagtga     1680

cttgtaagat gctgaattat tcatgataat acagtgaatg ttctgggtcc atgtactcag     1740

ataaacatga agaaaataag caaagaaaaa tggagactgg gaaagcaaag ctgttttcat     1800

cctataattg aagtagtgtg gagcattaac ttgtggatga ttcagagtta aaagataaaa     1860

agacgccaga gttctcgctg aagaa                                           1885


<210> 1800
<211> 1957
<212> DNA
<213> Homo sapiens

<400> 1800
attggcgcca agatggcgat ggagatgagg cttccagtgg ctcgcaagcc tcttagcgag       60

agactgggcc gcgacactaa gaaacatcta gtggtgccgg gggatacaat cactacggac      120

acaggattca tgcggggcca tggaacgtat atgggagaag agaagctcat tgcatctgtt      180

gctggctctg tggagagagt aaacaagttg atctgtgtga aagctttgaa aaccagatac      240

attggtgaag taggagacat cgtagtggga cgaatcacag aggttcaaca gaagaggtgg      300

aaggtggaga ccaactccag gctggattcg gtcttgctgc tctcgtccat gaaccttcct      360

ggaggagagc tgaggagaag atctgcagaa gatgagcttg caatgagagg tttcttacag      420

gaaggggacc ttatcagtgc tgaggtccag gcagtgttct ctgacggagc tgtctctttg      480

cacacgagga gcctgaaata tggaaaagtt tccccctccc tggtgaaacg gcagaagacc      540

cactttcatg atttgccatg tggtgcctca gtgattctcg gtaacaacgg cttcatctgg      600

atttacccaa cacctgagca caaagaagag gaagcagggg gcttcattgc aaacctggag      660

cctgtctctc ttgctgatcg agaggtgata tcccggcttc ggaactgcat catctcgctg      720

gtaactcaga ggatgatgct gtatgatacc agcatcctgt actgctatga agcatccctt      780

ccacatcaga tcaaagacat cttaaagcca gaaataatgg aggagattgt gatggaaaca      840

cgccagaggc ttttggaaca ggagggataa ggaggtgctc cagaagcacg ggactgtgga      900

ccttgcagga gtgaagactg tgatgtgtgg tccccatatg tggctcagca aagactcgag      960

agatcatccc tttgtctgca ttgacggccc tgtgacggcc tccagcccac aggcctgctt     1020

tctcctgtcc taacaccaag cctgggtggc agatgaacag tgcttccttg ggttgccagc     1080

tgagtcccgg tattagggaa tagtttcagc tctttcaaag tgcacagtgt tacagtcgaa     1140

tgggctccca tcctggaata atatggagaa tcctttgtct tccactcact gtcattcaca     1200

aggcacagtg ccccatgaaa ttgccccaat agaaaacatg gcatccctga cctccaaatg     1260

gtctgttttg gcctccattc ctatatcctt taaatgactg agaatgcagc tggtaaagtt     1320

ggaagaataa agttaaccaa gcaggccagg cacggtggct cacgcctata atcccagcac     1380

ttagggaggc caaggcgggc agatcacctg aggtcaatag ttcgagacca gcctggccaa     1440

caaggtgaaa ccccatctct actaaaaata caaaaaatta gccaggtgtg gtggtgtgca     1500

cctgtagtcc cagctatttg ggaggctgag gtgggagaat cacttgaacc tgggaggcgg     1560

aggttgcagt gagctgaaat cgcgtaccac actccagcct gggtgacaga gcgagactgt     1620

gtttcaaaga aaaaaaaaaa caagcagcct tttgcttggt tggaatctga ttttctgttg     1680

cgtgttcctt gtagccatag atgtgattat gtccacaccg ggctgcctta atctgtcctg     1740

cttggagagt gacttgtaag atgctgaatt attcatgata atacagtgaa tgttctgggt     1800

ccatgtactc agataaacat gaagaaaata agcaaagaaa aatggagact gggaaagcaa     1860

agctgttttc atcctataat tgaagtagtg tggagcatta acttgtggat gattcagagt     1920

taaaagataa aaagacgcca gagttctcgc tgaagaa                              1957


<210> 1801
<211> 2040
<212> DNA
<213> Homo sapiens

<400> 1801
ggcctggagt tgtggagtcg gatatcgcag ctcccgactg agctgcgcct gcgcaactca       60

ttggcgccaa gatggcgatg gagatgaggc ttccagtggc tcgcaagcct cttagcgaga      120

gactgggccg cgacactaag aaacatctag tggtgccggg ggatacaatc actacggaca      180

caggattcat gcggggccat ggaacgtata tgggagaaga gaagctcatt gcatctgttg      240

ctggctctgt ggagagagta aacaagttga tctgtgtgaa agctttgaaa accagataca      300

ttggtgaagt aggagacatc gtagtgggac gaatcacaga ggttcaacag aagaggtgga      360

aggtggagac caactccagg ctggattcgg tcttgctgct ctcgtccatg aaccttcctg      420

gaggagagct gaggagaaga tctgcagaag atgagcttgc aatgagaggt ttcttacagg      480

aaggggacct tatcagtgct gaggtccagg cagtgttctc tgacggagct gtctctttgc      540

acacgaggag cctgaaatat ggaaaactag gtcagggggt tttggtccag gtttccccct      600

ccctggtgaa acggcagaag acccactttc atgatttgcc atgtggtgcc tcagtgattc      660

tcggtaacaa cggcttcatc tggatttacc caacacctga gcacaaagaa gaggaagcag      720

ggggcttcat tgcaaacctg gagcctgtct ctcttgctga tcgagaggtg atatcccggc      780

ttcggaactg catcatctcg ctggtaactc agaggatgat gctgtatgat accagcatcc      840

tgtactgcta tgaagcatcc cttccacatc agatcaaaga catcttaaag ccagaaataa      900

tggaggagat tgtgatggaa acacgccaga ggcttttgga acaggaggga taaggaggtg      960

ctccagaagc acgggactgt ggaccttgca ggagtgaaga ctgtgatgtg tggtccccat     1020

atgtggctca gcaaagactc gagagatcat ccctttgtct gcattgacgg ccctgtgacg     1080

gcctccagcc cacaggcctg ctttctcctg tcctaacacc aagcctgggt ggcagatgaa     1140

cagtgcttcc ttgggttgcc agctgagtcc cggtattagg gaatagtttc agctctttca     1200

aagtgcacag tgttacagtc gaatgggctc ccatcctgga ataatatgga gaatcctttg     1260

tcttccactc actgtcattc acaaggcaca gtgccccatg aaattgcccc aatagaaaac     1320

atggcatccc tgacctccaa atggtctgtt ttggcctcca ttcctatatc ctttaaatga     1380

ctgagaatgc agctggtaaa gttggaagaa taaagttaac caagcaggcc aggcacggtg     1440

gctcacgcct ataatcccag cacttaggga ggccaaggcg ggcagatcac ctgaggtcaa     1500

tagttcgaga ccagcctggc caacaaggtg aaaccccatc tctactaaaa atacaaaaaa     1560

ttagccaggt gtggtggtgt gcacctgtag tcccagctat ttgggaggct gaggtgggag     1620

aatcacttga acctgggagg cggaggttgc agtgagctga aatcgcgtac cacactccag     1680

cctgggtgac agagcgagac tgtgtttcaa agaaaaaaaa aaacaagcag ccttttgctt     1740

ggttggaatc tgattttctg ttgcgtgttc cttgtagcca tagatgtgat tatgtccaca     1800

ccgggctgcc ttaatctgtc ctgcttggag agtgacttgt aagatgctga attattcatg     1860

ataatacagt gaatgttctg ggtccatgta ctcagataaa catgaagaaa ataagcaaag     1920

aaaaatggag actgggaaag caaagctgtt ttcatcctat aattgaagta gtgtggagca     1980

ttaacttgtg gatgattcag agttaaaaga taaaaagacg ccagagttct cgctgaagaa     2040


<210> 1802
<211> 4474
<212> DNA
<213> Homo sapiens

<400> 1802
ggagtttcgg ccttcgcctg ctggaaaagc agtaggatcg gccagtggcg acagcaggag       60

ctgagcctaa gccctggcgg ggctttgggc tgtagattcc tgtctgacta aagggacctc      120

aaaaaggagg gaaaatggct tctgagtctg aaactctgaa tcccagtgct aggataatga      180

ccttttatcc aactatggaa gagttccgaa acttcagtag atacattgcc tacattgaat      240

cccaaggagc tcatcgggca gggctagcca aggttgttcc tccaaaagag tggaagccac      300

gagcatccta tgatgacatt gatgatttgg tcattcctgc ccccattcaa cagctggtga      360

cggggcagtc tggcctcttt actcagtaca acatacagaa gaaagccatg actgttcgag      420

agttccgcaa gatagccaat agcgataagt actgtacccc acgctatagt gagtttgaag      480

agctcgagcg gaaatactgg aaaaatctta cattcaatcc tccaatctat ggtgcagatg      540

tgaatggtac cctctatgaa aagcatgttg atgagtggaa tattggccgg ctgagaacaa      600

tcctggactt ggtggaaaag gagagtggga tcaccattga gggtgtgaac accccatacc      660

tgtactttgg catgtggaag acatcctttg cttggcacac tgaagacatg gacctctaca      720

gcatcaacta cctgcacttt ggagaaccaa agtcctggta ctctgttcca cctgagcatg      780

gaaagcggtt ggaacgcctc gccaaaggct ttttcccagg aagtgctcaa agctgtgagg      840

catttctccg ccacaagatg accctgattt ccccgttaat gctgaagaaa tatggaattc      900

cctttgacaa ggtgactcaa gaggctggag agtttatgat cactttccct tatggttacc      960

atgccggctt taaccatggt tttaactgtg cggagtctac caattttgct acccgtcggt     1020

ggattgagta cggcaagcaa gctgtgctgt gctcctgtag aaaggacatg gtgaagatct     1080

ccatggatgt gtttgtgaga aagttccagc cagaaaggta caaactttgg aaagctggga     1140

aggacaacac agttattgac catactctgc ccacgccaga agcagctgag tttcttaagg     1200

agagtgaact gcctccaaga gctggcaacg aggaggagtg cccagaggag gacatggaag     1260

gggtggagga tggagaggaa ggagacctga agacaagcct ggccaagcac cgaataggga     1320

caaagaggca ccgagtttgt cttgaaatac cacaggaggt gagtcagagt gagctcttcc     1380

ccaaggagga tctgagttct gagcagtatg agatgacgga gtgcccggca gccctcgccc     1440

ctgtgaggcc cacccatagc tctgtgcggc aagttgagga tggtcttacc ttcccagatt     1500

attctgactc cactgaagtc aaatttgaag agcttaaaaa tgtcaaacta gaagaggagg     1560

atgaggagga agaacaagca gcagctgcct tggatctttc tgtgaatcct gcgtctgtag     1620

ggggacgcct tgtcttctca ggctccaaaa agaaatcatc ttctagcctg ggctctggct     1680

cttcacggga ttctatctct tctgattcag aaactagtga gcctctctcc tgccgagccc     1740

aagggcaaac gggagttctc actgtgcaca gttatgccaa aggggatggc agggtcactg     1800

tgggagagcc atgcacgagg aagaaaggaa gcgccgctag aagtttcagt gagcgggagc     1860

tggcagaggt tgcagatgaa tacatgtttt ccctagaaga gaataagaag tccaagggac     1920

gccgtcagcc tttaagcaag ctcccccgcc atcacccact tgtgctgcag gagtgtgtca     1980

gtgatgatga gacatctgaa cagctgaccc ctgaggaaga ggctgaggag acagaggcct     2040

gggccaagcc tctgagccaa ctgtggcaga accgacctcc aaactttgag gctgagaagg     2100

aattcaatga gaccatggcc caacaggccc ctcactgcgc tgtctgtatg atcttccaga     2160

cttatcatca ggttgaattt ggaggcttta atcagaactg tggaaatgct tcagatttag     2220

ccccccagaa gcagaggacc aagccattga ttccagaaat gtgcttcact tcgactggct     2280

gcagcacgga catcaacctt tctactcctt atcttgagga ggatggcacc agcatactcg     2340

tttcctgcaa gaagtgcagc gtccgggtcc atgccagttg ctatggggtc ccccctgcaa     2400

aggcttctga agactggatg tgttctcggt gttcagccaa tgccctagag gaggactgct     2460

gtttatgctc attacgagga ggggccctgc agagagcaaa tgatgacagg tgggtccacg     2520

tttcatgtgc tgtggcaatt ctggaagcaa ggtttgtcaa cattgcagaa agaagtccgg     2580

tggatgtgag caaaatcccc ctgccccgct tcaaactgaa atgtatcttc tgtaagaagc     2640

ggaggaaaag aactgctggc tgctgtgtgc agtgttctca cggccgctgc ccaactgcct     2700

tccatgtgag ctgcgcccag gctgccggtg tgatgatgca gcctgacgac tggccttttg     2760

tggtcttcat tacctgcttt cggcacaaga ttcctaattt ggagcgtgcc aagggggcct     2820

tgcaaagcat cactgcaggc cagaaagtca ttagcaagca taagaacggg cgcttctacc     2880

agtgtgaagt ggtcaggctc accaccgaga ccttctatga agtcaacttt gatgatggct     2940

ccttcagcga caatctttat cctgaggaca tagtgagcca ggactgtctc cagtttggtc     3000

ctcctgctga aggggaagtg gtccaagtga gatggacaga cggccaagtc tatggagcca     3060

agtttgtggc ctcccaccct atccaaatgt accaggtgga gtttgaggat ggctcacaac     3120

ttgtggttaa gagagatgat gtatacacac tggatgaaga gcttcccaag agagtcaaat     3180

ctagactgtc agtagcctca gacatgcgct tcaatgagat tttcacagag aaagaggtta     3240

agcaagaaaa gaaacggcaa cgagttatca actcaagata ccgggaagat tatattgagc     3300

ctgcactata ccgggccatc atggagtagg tgcttccagg gtccaaggga ttctcagcca     3360

tccaggcaag agcactctgg gttccacagc acagcagaca tggaacgctg aagtctctga     3420

aagtgaagtt gtaaaaagaa aaggaatgaa ataaccgacc catcatcttc tcacccaccc     3480

tcattgcatt ccgctgtagt gaaaggacga gccatttctg ggcacgtggc agcagtcgct     3540

gatctcccag ctgaggggct gagcactgga atgctgtggc tgcactggcc ccagtccata     3600

gaggggtcaa ctatgctggc tggactggct gccttgttcc tggcctagga cttagcttca     3660

taactatcac ctgcaccgac taggctgagg tgctggtact tgccccaacc cctacttttg     3720

tatttatatg tgtgtgtgtg tgtgcgtgcg tgcgtgcgtg cgtgtatgtt tggtctggac     3780

cagcttctgc cagcccctgg cctttacttt cttccttgcc tatgcagggc aaacaaaatg     3840

tgaaattctg ccctcagctg agctgagtaa gggctcctgg gggttggctg gagatgggtg     3900

tggcatctgt ccaggcctgg aaccgtctca agacagtgct ggcaaagctg cagtattgag     3960

atgctaagga gctgatgcca cctctttgtc ttcccctaaa ggagaacatg gggataacat     4020

gggtgtgtgc ccacaacact ctaggtgcag agcccctgtg gcaaagtatt acagggtgtg     4080

ggtggggatt accctgaatc ggggatttta atgatggaag caggcagagc ctggtgggtg     4140

attctgtcaa cagaaaattg caatcatgca ggggctggga gggttaggat gaaaaaactg     4200

gggccattgg aggcccactg taggtgggag ggagctgatt ttggggtggg gggtgggact     4260

agagggcaat actgaagggg ttaaacaggt ttttgctcct caagaatttg tttgcctggg     4320

cccaggattg gagggcttca caccaatacc ctgtgtatac aagaatcaga tttataatac     4380

ttcccctttt ttgttacgta tgaacactat aaaccaaatt attttgaaaa ctggtgcatc     4440

accttgtcct tagcaataaa atgtgttgag caga                                 4474


<210> 1803
<211> 4305
<212> DNA
<213> Homo sapiens

<400> 1803
ctcagagggg gcgcgcttga ctgacaggcg gcggcggcgc agttgcgagt gcaggctcct       60

tgccagaggc ctccactcac tccagacccc tatagcccgt cgctgtcagc tgtcaacaaa      120

ggatgcgaat gctggccgct tcctgtgggc ttcgtgtcac ccagaggtga gcccaggcca      180

ggatggggga ctccagggac ctttgccctc accttgactc cataggagag gtgaccaaag      240

aggacttgct gctcaaatct aagggaacct gtcagtcgtg tggggtcacc ggaccaaacc      300

tatgggcctg tctgcaggtt gcctgcccct atgttggctg cggagaatcc tttgctgacc      360

acagcaccat tcatgcacag gcaaaaaagc acaacttgac cgtgaacctg accacgttcc      420

gactgtggtg ttacgcctgt gagaaggagg tattcctgga gcagcggctg gcagcccctc      480

tgctgggctc ctcttccaag ttctctgaac aggactcccc gccaccctcc caccctctga      540

aagctgttcc tattgctgtg gctgatgaag gagagtctga gtcagaggac gatgacctga      600

aacctcgagg cctcacgggc atgaagaacc tcgggaactc ctgctacatg aacgctgccc      660

tgcaggccct gtccaattgc ccgccgctga ctcagttctt cttggagtgt ggcggcctgg      720

tgcgcacaga taagaagcca gccctgtgca agagctacca gaagctggtc tctgaggtct      780

ggcataagaa acggccaagc tacgtggtcc ccaccagtct gtctcatggg atcaagttgg      840

tcaacccaat gttccgaggc tatgcccagc aggacaccca agagttcctt cgctgcctga      900

tggaccagct gcacgaggag ctcaaggagc cggtggtggc cacggtggcg ctgacggagg      960

ctcgggactc agattcgagt gacacggatg agaaacggga gggtgaccgg agcccatcag     1020

aagatgagtt cttgtcctgt gactcgagca gtgaccgggg tgagggtgac gggcaggggc     1080

gtggcggggg cagctcgcag gccgagacgg agctgctgat cccagatgag gcgggccgag     1140

ccatctctga gaaggagcgg atgaaggacc gcaagttctc ctggggccag cagcgtacaa     1200

actcggagca agtggacgag gacgctgatg tggacactgc catggctgcc cttgacgacc     1260

agcccgcgga ggcccagccc ccgtcaccac ggtcctccag cccctgccgg acgccagagc     1320

cggacaatga tgctcaccta cgcagctcct ctcgcccctg cagccccgtc caccaccacg     1380

agggccatgc caagctgtct agcagccccc ctcgtgcaag ccccgtgagg atggcaccgt     1440

cgtacgtgct caagaaagcc caggtattga gtgctggcag ccggaggcgg aaggagcagc     1500

gctaccgcag cgtcatctca gacatctttg acggctccat tctcagcctt gtgcagtgtc     1560

tcacctgtga ccgggtatcc accacagtgg aaacgttcca ggacttatca ctgcccattc     1620

ctggaaagga ggacctggcc aagctccatt cagccatcta ccagaatgtg ccggccaagc     1680

caggcgcctg tggggacagc tatgccgccc agggctggct ggccttcatt gtggagtaca     1740

tccgacggtt tgtggtatcc tgtaccccca gctggttttg ggggcctgtc gtcaccctgg     1800

aagactgcct tgctgccttc tttgccgctg atgagttaaa gggtgacaac atgtacagct     1860

gtgagcggtg taagaagctg cggaacggag tgaagtactg caaagtcctg cggttgcccg     1920

agatcctgtg cattcaccta aagcgctttc ggcacgaggt gatgtactca ttcaagatca     1980

acagccacgt ctccttcccc ctcgaggggc tcgacctgcg ccccttcctt gccaaggagt     2040

gcacatccca gatcaccacc tacgacctcc tctcggtcat ctgccaccac ggcacggcag     2100

gcagtgggca ctacatcgcc tactgccaga acgtgatcaa tgggcagtgg tacgagtttg     2160

atgaccagta cgtcacagaa gtccacgaga cggtggtgca gaacgccgag ggctacgtac     2220

tcttctacag gaagagcagc gaggaggcca tgcgggagcg acagcaggtg gtgtccctgg     2280

ccgccatgcg ggagcccagc ctgctgcggt tctacgtgtc ccgcgagtgg ctcaacaagt     2340

tcaacacctt cgcggagcca ggccccatca ccaaccagac cttcctctgc tcccacggag     2400

gcatcccgcc ccacaaatac cactacatcg acgacctggt ggtcatcctg ccccagaacg     2460

tctgggagca cctgtacaac agattcgggg gtggccccgc cgtgaaccac ctgtacgtgt     2520

gctccatctg ccaggtggag atcgaggcac tggccaagcg caggaggatc gagatcgaca     2580

ccttcatcaa gttgaacaag gccttccagg ccgaggagtc gccgggcgtc atctactgca     2640

tcagcatgca gtggttccgg gagtgggagg cgttcgtcaa ggggaaggac aacgagcccc     2700

ccgggcccat tgacaacagc aggattgcac aggtcaaagg aagcggccat gtccagctga     2760

agcagggagc tgactacggg cagatttcgg aggagacctg gacctacctg aacagcctgt     2820

atggaggtgg ccccgagatt gccatccgcc agagtgtggc gcagccgctg ggcccagaga     2880

acctgcacgg ggagcagaag atcgaagccg agacgcgggc cgtgtgatct gctgggctag     2940

tctccccatg tgccccaccc cgcggaaggc gtgtttgtgc ccagaagaga ggccgggctg     3000

ctgcagaacc ccgccgtgta aagaggcaga aaagttggtt tggtttgcag taacgctgca     3060

actagaaaat atatgcactt caggcttgtt gaaacgacca agactctgtg acgttaattt     3120

gggtctttgt cctggcagtg cctctgccag tcactgtcat cgttgtgtcc cccacaactg     3180

tcctcttgct agctcggccc agctttgtcc ctggagcccg atgctacccc tgtcagacag     3240

aggctgcggc ctgggccaga gtcagggagt agctgctgct tcacggcgtc tccactgtgc     3300

gattggcccg gagccccgaa gactcggagg gagctgctca gggccggtga gcgcagccag     3360

aagccctggc cagtgaggag ctcacaggtc ctccctggtg gtcccgccgc acctctgcat     3420

ctcctgggcg tcaccaggaa ggctctgaag tcccgggctg ctctcagcac ttctcctgca     3480

gactgaagac tctggactca ttgctgattg gaacaccagg aggaggttgg atttctgcca     3540

gtgggggatg tttctggagg cagctggtcc cccacaccgc gtcctgctga gcctgccccc     3600

tggattggct gtaatttgcc tcgaagttca gcagttcatc ttcatgggaa atttgctgag     3660

cccccaccag ggaaccggat gatgaaacag ggatacctca cagcttggcc atttgaggca     3720

aaggcagctt cccgagctga tgctaaagaa gacagacttt cccttcctcc cagcagcagc     3780

agtgcagagc ccacctggag ggatgtgggg gctgtgcagg gtgcagcgct caggtggatc     3840

ctgggaagca gcctctggat gctgagtgga gggagccact gagcacagca aggcaccaaa     3900

gcccctggag aaaccgccag ggcgaggtgc gaccatcatc aggatcaaag cagacggggc     3960

gtgggtgggg aaggggctct gggaccagac cccccacact actgcgtctt tgtttctatc     4020

agtctttgta gaagcaggtg gtggtggaaa ttccagcagg tgggtcccgc agaggccctg     4080

aggcctcact tttcggatct tctgtcccag atcctgctcc ctccctgctg agcctggggt     4140

tcccctggca ttggccccag ccttctgaaa gccggcgctg cagccagagg ccgcacgctg     4200

cactgtcgcg acgcagagag gcttctgtgc aggctgggat cgggccccat gtctgtgctg     4260

tctagtttgt gttcaaaatg tcagaataaa cacagaataa atgtt                     4305


<210> 1804
<211> 1985
<212> DNA
<213> Homo sapiens

<400> 1804
cggcaggcgg gtgcgcggag ggctggtgcc ccgcagcagg tgggcggggt gcggttggcg       60

gcggcggctg ggccgggggc tgccggctgc gctcgggccg tgcgcggcgg ccgtgcgggc      120

acgccatgga cttcaacatg aagaagctgg cgtcggacgc gggcatcttc ttcacccggg      180

cggtgcagtt cacggaggag aaatttggcc aggctgagaa gactgagctt gatgcccact      240

ttgaaaacct tctggcccgg gcagacagca ccaagaactg gacagagaag atcttgaggc      300

agacagaggt gctgctgcag cccaacccca gtgcccgagt ggaggagttc ctgtatgaga      360

agctggacag gaaggtcccc tcaagggtca ccaacgggga gctgctggct cagtacatgg      420

cagacgcggc cagtgagctg gggccgacca ccccctatgg gaagacactg atcaaggtgg      480

cagaagctga aaagcaactg ggagccgcgg agagggattt tatccacacg gcctccatca      540

gcttcctcac acccttgcgc aacttcctgg agggggactg gaagaccatc tcgaaggaga      600

ggcggctcct ccaaaaccgg cgtctggact tggatgcctg caaagcgagg ctgaagaagg      660

ccaaggctgc agaagccaaa gccacgtgtg agggagatac ggtgcctgac tttcaggaga      720

ctagacctcg taattacatt ctctcggcca gcgcctccgc gctctggaat gatgaagtgg      780

acaaggccga gcaggagctc cgcgtggccc agacagagtt tgaccggcaa gcagaagtga      840

cccgtctctt gctggaggga atcagtagca ctcacgtgaa ccacctgcgc tgcctccacg      900

agttcgtcaa gtctcagaca acctactacg cacagtgcta ccgccacatg ctggacttgc      960

agaagcagct gggcagctcc cagggtgcca tatttcccgg caccttcgtg ggcaccacag     1020

agcccgcctc cccacccctg agcagcacct cacccaccac tgctgcggcc actatgcctg     1080

tggtgccctc tgtggccagc ctggcccctc cgggggaggc ctcgctctgc ctggaagagg     1140

tggccccccc tgccagtggg acccgcaaag ctcgggtgct ctatgactac gaggcagccg     1200

acagcagtga gctggccctg ctggctgatg agctcatcac tgtctacagc ctgcctggca     1260

tggaccctga ctggctcatt ggcgagagag gcaacaagaa gggcaaggtc cctgtcacct     1320

acttggaact gctcagctag gcaggtgccc ccatcccccc cgcattctgg cctaggcagg     1380

agaggatggg cgcagccctg ccacttaact tgtttgttgg tgacacagtt gttcagagtg     1440

gggagaattc accccattct gtccctgccc ctagtcacct agctgtgagg gtgcctgagg     1500

ctgaatggct ccacccctcc cccagccctg cttctgacct gtggctctgg agcccctgcc     1560

cctgcctgca tccccgagca ccccaccctc caggctccac taaggaggga ggggctgtct     1620

gcagcagctg cactcagcac ctaggccagg gtggggccgc cgcagatggg ctcaggaagc     1680

cccaggtgca ctcagcgaga gccctgcctt tcagttgcca aaagctgcat caggggaatg     1740

cggcaaggca cacagggctc tggcagcccc tggggactgg gcgctgcccc tgggagggga     1800

gagcctggcc agggctggtg ttgggcccgg agcagcatct tccggtgcta tcctcccctc     1860

ccacccctca cagctcaagc caagtccagc ggccgcagtc ttcacctctc cacactcact     1920

ttttatctgg tgtttttact tctgcctgcg tttgctctct agccaataaa ccgtccttgt     1980

gtgcg                                                                 1985


<210> 1805
<211> 1365
<212> DNA
<213> Homo sapiens

<400> 1805
ggctgggccg ggggctgccg gctgcgctcg ggccgtgcgc ggcggccgtg cgggcacgcc       60

atggacttca acatgaagaa gctggcgtcg gacgcgggca tcttcttcac ccgggcggtg      120

cagttcacgg aggagaaatt tggccaggct gagaagactg agcttgatgc ccactttgaa      180

aaccttctgg cccgggcaga cagcaccaag aactggacag agaagatctt gaggcagaca      240

gaggtgctgc tgcagcccaa ccccagtgcc cgagtggagg agttcctgta tgagaagctg      300

gacaggaagg tcccctcaag ggtcaccaac ggggagctgc tggctcagta catggcagac      360

gcggccagtg agctggggcc gaccaccccc tatgggaaga cactgatcaa ggtggcagaa      420

gctgaaaagc aactgggagc cgcggagagg gattttatcc acacggcctc catcagcttc      480

ctcacaccct tgcgcaactt cctggagggg gactggaaga ccatctcgaa ggagaggcgg      540

ctcctccaaa accggcgtct ggacttggat gcctgcaaag cgaggctgaa gaaggccaag      600

gctgcagaag ccaaagccac gacggtgcct gactttcagg agactagacc tcgtaattac      660

attctctcgg ccagcgcctc cgcgctctgg aatgatgaag tggacaaggc cgagcaggag      720

ctccgcgtgg cccagacaga gtttgaccgg caagcagaag tgacccgtct cttgctggag      780

ggaatcagta gcactcacgt gaaccacctg cgctgcctcc acgagttcgt caagtctcag      840

acaacctact acgcacagtg ctaccgccac atgctggact tgcagaagca gctgggcaga      900

tttcccggca ccttcgtggg caccacagag cccgcctccc cacccctgag cagcacctca      960

cccaccactg ctgcggccac tatgcctgtg gtgccctctg tggccagcct ggcccctccg     1020

ggggaggcct cgctctgcct ggaagaggtg gccccccctg ccagtgggac ccgcaaagct     1080

cgggtgctct atgactacga ggcagccgac agcagtgagc tggccctgct ggctgatgag     1140

ctcatcactg tctacagcct gcctggcatg gaccctgact ggctcattgg cgagagaggc     1200

aacaagaagg gcaaggtccc tgtcacctac ttggaactgc tcagctagct caagccaagt     1260

ccagcggccg cagtcttcac ctctccacac tcacttttta tctggtgttt ttacttctgc     1320

ctgcgtttgc tctctagcca ataaaccgtc cttgtgtgcg agtca                     1365


<210> 1806
<211> 2982
<212> DNA
<213> Homo sapiens

<400> 1806
cgggcgggca ggcgggcagg ccggcaggcg ggtgcgcgga gggctggtgc cccgcagcag       60

gtgggcgggg tgcggttggc ggcggcggct gggccggggg ctgccggctg cgctcgggcc      120

gtgcgcggcg gccgtgcggg cacgccatgg acttcaacat gaagaagctg gcgtcggacg      180

cgggcatctt cttcacccgg gcggtgcagt tcacggagga gaaatttggc caggctgaga      240

agactgagct tgatgcccac tttgaaaacc ttctggcccg ggcagacagc accaagaact      300

ggacagagaa gatcttgagg cagacagagg tgctgctgca gcccaacccc agtgcccgag      360

tggaggagtt cctgtatgag aagctggaca ggaaggtccc ctcaagggtc accaacgggg      420

agctgctggc tcagtacatg gcagacgcgg ccagtgagct ggggccgacc accccctatg      480

ggaagacact gatcaaggtg gcagaagctg aaaagcaact gggagccgcg gagagggatt      540

ttatccacac ggcctccatc agcttcctca cacccttgcg caacttcctg gagggggact      600

ggaagaccat ctcgaaggag aggcggctcc tccaaaaccg gcgtctggac ttggatgcct      660

gcaaagcgag gctgaagaag gccaaggctg cagaagccaa agccacgacg gtgcctgact      720

ttcaggagac tagacctcgt aattacattc tctcggccag cgcctccgcg ctctggaatg      780

atgaagtgga caaggccgag caggagctcc gcgtggccca gacagagttt gaccggcaag      840

cagaagtgac ccgtctcttg ctggagggaa tcagtagcac tcacgtgaac cacctgcgct      900

gcctccacga gttcgtcaag tctcagacaa cctactacgc acagtgctac cgccacatgc      960

tggacttgca gaagcagctg ggcagatttc ccggcacctt cgtgggcacc acagagcccg     1020

cctccccacc cctgagcagc acctcaccca ccactgctgc ggccactatg cctgtggtgc     1080

cctctgtggc cagcctggcc cctccggggg aggcctcgct ctgcctggaa gaggtggccc     1140

cccctgccag tgggacccgc aaagctcggg tgctctatga ctacgaggca gccgacagca     1200

gtgagctggc cctgctggct gatgagctca tcactgtcta cagcctgcct ggcatggacc     1260

ctgactggct cattggcgag agaggcaaca agaagggcaa ggtccctgtc acctacttgg     1320

aactgctcag ctaggcaggt gcccccatcc cccccgcatt ctggcctagg caggagagga     1380

tgggcgcagc cctgccactt aacttgtttg ttggtgacac agttgttcag agtggggaga     1440

attcacccca ttctgtccct gcccctagtc acctagctgt gagggtgcct gaggctgaat     1500

ggctccaccc ctcccccagc cctgcttctg acctgtggct ctggagcccc tgcccctgcc     1560

tgcatccccg agcaccccac cctccaggct ccactaagga gggaggggct gtctgcagca     1620

gctgcactca gcacctaggc cagggtgggg ccgccgcaga tgggctcagg aagccccagg     1680

tgcactcagc gagagccctg cctttcagtt gccaaaagct gcatcagggg aatgcggcaa     1740

ggcacacagg gctctggcag cccctgggga ctgggcgctg cccctgggag gggagagcct     1800

ggccagggct ggtgttgggc ccggagcagc atcttccggt gctatcctcc cctcccaccc     1860

ctcacagctc aagccaagtc cagcggccgc agtcttcacc tctccacact cactttttat     1920

ctggtgtttt tacttctgcc tgcgtttgct ctctagccaa taaaccgtcc ttgtgtgcga     1980

gtcacctggg ctcctgtcag ggcctggccc tgagggtggt aaagggaaag gtagactcac     2040

cctctgcccc actcttccac agagtgagca ggggccctgt ggctgccccg gcccccagct     2100

ctctagttgg gaagaagtgc agccctccct gtcttctgcg gggcctgtgc ctctcagagg     2160

gcagtgctgt tcctggacat gaagccgcac aaggaacgtt ttattcctaa gaaaaagttt     2220

cctaaatttg gattgtggag cggactgtag aatgcgtctg acagttcagt tcaagcacaa     2280

gaagtgggta gcggtcagtg ctgtctgcag gtcgggcgtt tcacccagca tgtgcccccg     2340

tgccatgggt tctcatgccg tcctcagtgt ccacatttca cagatgagat cagcaagaca     2400

gtcagctcct caagggacca cagttggcaa gtggccaagc agggactgaa gcccaggcag     2460

cctgattcta gaaaccctaa gtgatgtctg tgttttagat ggcccctagc aggacctagc     2520

attctgactt cagtcctgag aaggccaaca gccagtaggc cccactgttg gggcttctga     2580

agaggggatc gggggatgac gggggcacgg ggctataaat aggaaggcac agagcttcaa     2640

gaaaggctca cccagggatg agctcagccc actgggccaa tgaaagcagg gtcaaggaca     2700

ggaccagcgc aggccaagga agggaatatc tgacagcgcc cacccagcca aaccctcagc     2760

ccaaggacag gaatgaggag atgctggtga actagccatc catcagtacc tgccttcccc     2820

cgaggctgca gccccactcc caggcgcctg gccaggggag ttttctaggt tctgagagcc     2880

acgttgtcat ccctgggctt tgaagttaaa catcacacag ctgtctataa acaagatttt     2940

aatatctgta taaatagacc acagaattac caaaactgca aa                        2982


<210> 1807
<211> 962
<212> DNA
<213> Homo sapiens

<400> 1807
gagctatgag ctggacctgt ccgcgttgcc agcaacctgt tttcttcgct gagaaggtga       60

gctccctggg caagaactgg caccgcttct gcctgaaatg tgagcgctgc cacagcatcc      120

tgtcccctgg cgggcatgca gagcacaatg ggaggccata ctgccacaag ccatgctatg      180

gggctctctt tggacccagg ggggtgaaca ttggtggtgt aggctcctac ttgtacaatc      240

cccccactcc cagccctggc tgcaccactc ctctcagccc cagcagcttc agccctccca      300

ggccaaggac tggcctcccc caaggcaaga aaagccctcc ccatatgaag acattcactg      360

gggagacctc gctgtgccct ggctgtgggg agcccgtcta ttttgctgag aaggtgatgt      420

cattaggcag aaattggcac cgaccgtgtc tgaggtgcca gcgttgccac aagaccctga      480

ctgctgggag tcatgctgag catgatggag tcccctactg ccacgtcccc tgctacggct      540

acctgtttgg ccccaaaggt gtgaacattg gcgatgtggg ctgctacatc tatgacccag      600

tgaagataaa attcaaatga gacgctcaca aaaaaggtca ccctaactca ggcctcccat      660

catgcccctc atggtccaat ggaagctaca aaaatctcca gtcccatggg ggttggggaa      720

ggtgggatct tgggggcctg ggcctaggct ccatggtagg ccagagagtc tagactttct      780

ctgccaattt tttccctttc ccatttctat ctggttaggg aacagcccgt tttgaagggt      840

atcctcctcc tggccatcac aacccctttc cccagcacat tctggagctt caaggtactc      900

ataaaacttg tgtttattga atttcagcct ctgtggcttc ttcaataaaa tgttggctcc      960

ca                                                                     962


<210> 1808
<211> 1495
<212> DNA
<213> Homo sapiens

<400> 1808
agagccagtt ccaaccccgg gatcgccgcg gaaccacgca cagagtctgc agaagtgcac       60

agctttatcg acagcgcttg aagcatggag tctcttcgcg ggtacaccca cagtgatatt      120

ggctaccgca gcctggcagt cggcgaggac atcgaggaag tgaatgatga gaaacttacc      180

gtgacctcgc tgatggcaag gggaggagag gacgaggaga atacacggtc caaacctgag      240

tacggaacag aagcggaaaa caacgttggc acggaagggt ccgtcccctc ggacgaccaa      300

gaccgtgagg gtggcggcgg ccacgagccg gagcaacagc aggaggagcc gcccctgacc      360

aagccggagc aacagcagga ggagccgccc ctgctcgagc tgaagcaaga gcaggaggag      420

ccgccccaga cgaccgtgga ggggccacag ccggcggagg ggccacaaac cgctgaggga      480

ccacagcccc cagagaggaa acgccgccgc cgcaccgcgt tcacgcagtt tcagctgcag      540

gagctagaga actttttcga tgaatctcaa tatcccgacg ttgtggcgcg agagagactt      600

gcagcacgcc tgaatttgac tgaagacaga gtgcaggttt ggtttcagaa cagaagagcc      660

aagtggaaac gaaatcagag ggtgctaatg ttgagaaaca ctgctactgc tgacctggcc      720

caccctttgg acatgttctt gggtggggcc tattatgctg ctcctgctct ggatcctgct      780

ttgtgtgttc atctggtgcc acaactacct agaccacctg tgctgcctgt gccacctatg      840

ccacccaggc cacccatggt ccctatgcca cccaggccac ccatagcacc tatgccaccc      900

atggcgcctg tgccacccgg ctcacgcatg gcgcctgtgc cacccgggcc acgcatggcg      960

cctgtgccac cctggccgcc catggcgcct gtgccaccct ggccgcccat ggcgcctgtg     1020

ccaaccgggc cgcccatggc gcctgtgcca cccgggccgc ccatggcgcg tgtgccaccc     1080

gggccgccca tggcgcgtgt gccacccggg ccgcccatgg cgcctctgcc acccgggccg     1140

cccatggcgc ctctgccacc cgggccgccc atggcgcctc tgccacccgg gccgcccatg     1200

gcgcctctgc cacccaggtc acatgtgcct cacactggcc tggctcctgt acacatcaca     1260

tgggcccctg tcatcaacag ttattatgca tgtccctttt tctaaagtaa ggtattcata     1320

acagtttttc caaagttctt tcctgccaga tagaaattgt gcacagcaca gcatcaagta     1380

attcgttaga tgcttgttaa atgaagtggg taggtgaaca aagttaacga atgccctgtt     1440

atttttgtag gccacataat tgtagtattt tcaataaaga tgtgacttaa tagta          1495


<210> 1809
<211> 1051
<212> DNA
<213> Homo sapiens

<400> 1809
gctactgtca catttcagtg atgtcacagc tgcaggtggt acagagccag caccaccatc       60

tgatgcccag cctgagtgct ggctgaactg agaggaacag ggttggtgcc tggcactggt      120

gttgctccat tcatctctga ggtctcacag ccccagcatg agtccatcag caaagaagag      180

gcccaagaac agcagggttt ccaagatgca agatgagaaa ctgcgggacg agacagagca      240

gcctgtgagc aaagtaattg agcggaaccg tctgagaacg gtgttaaaaa acttgtcgct      300

cttgaagcta ctcaagagct caaaccgccg gatccaagaa ctgcataagc tggccaaaag      360

gtgttggcat tcactgctca gtgttccaaa gattctccgc atctcctctg gggaaaacag      420

tgcctgcaat aaaacaaaac aaaataatga agagttccag gagatcgggt gctccgagaa      480

ggaactcaag tccaagaaat tagagtccac aggggaccct aagaaaaaag agtacaagga      540

gtggaagtcc caggtgcagt cagggatgag gaacaaggag aaaacgtcat tggcggcaat      600

gccacggaaa gaaaagcata tagagcctga ggttccaagg acatcgaggg atgatagctt      660

gaaccctgga gtccagggga ggcaaccact caccgagggc ccccgagtca tcttcattaa      720

gccctaccgc aatagaactc ccatggggca catgaagcag ctggatgtag ccgaccagtg      780

gatctggttt gaggggctgc ccacacgaat ccacctcccg gcgcccaggg tgatgtgcag      840

atcctccacc ctgcgttggg tcaagcgccg ctgcacccgc ttctgctccg catcacttga      900

aatgcctatg tggcatccat acaaggttga tgtgacctgg acgagagcca gaggtgcgag      960

cagagggtgg agatcgcgcc atcagctgaa ggggaggaat gggtggcgaa attcacgagt     1020

ctacaaataa gatcttccat atggcaccta a                                    1051


<210> 1810
<211> 5130
<212> DNA
<213> Homo sapiens

<400> 1810
gagaatcgaa gtgaggagcc gccagaggag agctgaggag aggaggggga ggtcgacgac       60

ctgggccctg ggcctctgaa ggaaaggagc tgtaacttct attgggaaaa tgactgactt      120

caaagttggc aggaggtgta atcaggctgc aggtcttggg gtgattaggg aatcattgag      180

gaagagcaga caggtctgtt tctttctagg ttcctgtaga gatctgtatg tagctgttca      240

cttggaagtt aattaagaaa gaacaaaaac tattcatttg gattcaaggt ccatctccac      300

tggtggctgt ggtggctttg gattgttgga agaccatcac cttcagcagg tctgcacttg      360

ggaacaatca ttctccccca gcccgagcgt gcctctgccc tctgtatcat tgacagaggc      420

tgtatgtttg gaaagagaac tttgtgactg cagaactgac agttgactct aattcttgct      480

accaagtttt tccccgaccc agtgaaagag tgttaagact tcgacctagg acacattgag      540

aaccaaggcc aagactggac agggccatat aactgggctt caaccatggc tgggactaag      600

aataagacaa gagcccaggc caaaactgaa aaaaaggctg ctatacaagc taaagctgga      660

gcagagaggg aggctactgg tgttgttagg cctgtagcca agaccagggc caaagcaaaa      720

gccaagacag ggtctaagac agatgcagta gcagagatga aggcagtgtc taagaacaag      780

gttgttgctg agacgaagga aggagctctg tcagagccta agactctggg caaagccatg      840

ggagatttca ctcccaaggc tgggaatgag tccaccagct ccacatgtaa aaatgaggct      900

ggtactgatg cctggttctg ggctggggaa gaggccacta tcaattcctg gttctggaat      960

ggagaagagg ctggtaatag tttcagcact aagaatgata aacctgaaat tggtgcccag     1020

gtctgtgctg aggagttgga acctgcggct ggggccgatt gcaaacctag gtcaggggct     1080

gaggaggagg aggaagagaa tgttattggg aactggtttt gggaaggaga tgatactagt     1140

tttgacccta atcctaaacc tgtgagcagg atagttaagc ctcagcctgt gtatgaaatt     1200

aatgaaaaaa ataggcccaa ggactggtct gaggtaacta tctggcccaa tgcccctgct     1260

gtaactccag ctgtgttagg atttagatcc caggcaccat ctgaggcaag ccctccttca     1320

tatattgttc tggcctccgc tgaagaaaat gcctgttctt tgcctgtggc aacagcttgc     1380

cgcccttcta ggaacactcg ctcatgctca cagcctatcc ctgagtgtcg ttttgattct     1440

gacccctgca tccagaccat agatgagatt agacgtcaaa tcaggatcag ggaggtaaat     1500

gggattaagc catttgcttg tccttgcaaa atggaatgct atatggattc tgaggaattt     1560

gaaaaacttg ttagcttact taagtcaact actgatcctc ttattcataa aatagcacgg     1620

attgcaatgg gtgtccataa tgttcaccca tttgcccaag agtttattaa cgaagtaggt     1680

gtagtgacac ttattgaaag cttgctcagt tttccttccc ctgaaatgag aaaaaagact     1740

gtaattactc tgaatcctcc ttctggggat gaaagacaac gcaaaattga attacatgtt     1800

aagcatatgt gtaaagaaac catgtcattt cctttgaact caccgggaca gcaatctgga     1860

ttaaagatac taggacaact gactactgat tttgtccatc actacattgt tgccaattac     1920

ttttcagagc ttttccattt gctgtcctca ggaaattgca aaaccagaaa tcttgttttg     1980

aaactacttt taaatatgtc tgaaaatcca actgcagcca gagacatgat caatatgaag     2040

gcattggcag cattaaaact catctttaac cagaaagagg caaaagccaa tcttgttagt     2100

ggtgtggcca tatttattaa cataaaggag catatcagaa aaggctcaat tgtagttgtt     2160

gatcacttga gttataatac actcatggcc attttcaggg aagttaaaga gattattgaa     2220

acaatgtaaa atgagccaga gatagaacat tttaagccat cttcaaactc tagcaggctg     2280

tacattacag tgtacacatt atacactgca tctttaacac agagtcacct gtgacaggct     2340

ctaggtttga gctagactat tttgggggta tcaaatgaat attatacctt gggctgaaaa     2400

tgtttgattt ttatcttgtc tagattggca tatttttaac attttactta agatagcaaa     2460

ccagttcgtt ttaagtaagc taacttgttc attagtatct gtggcttaaa atggcaaaaa     2520

agaaaatatc cttgagtttg taatctagtt acagaagtaa ggcatacaca cacacaaaga     2580

taacagtacc tagagagaga gtgtgtgtga gtgtgcgtgt ctctgtgtgt gcacgtgcac     2640

gctcatggcc aaatgtgcgc actctacata aaggaggcag gagttcctat aggctattta     2700

atgtaagaga aactattttt ctcctgttcc agctgtatca gatactcgtt ccgcaacaca     2760

gaaatgactc agaatctcag acaaaatgta ttatttgttc aattttaatt ttgctactac     2820

attcataact cttaaattgt taggctgttt catttacatc aaagttatct cacaaaagag     2880

aaggcaggaa acgttttgtg agtgcctatt ctatgtcaaa cactgtgttg gcaccatatt     2940

ttacaagttt ttttcctctt ctcacagtga tcttgtgagt tagttactta tatttttatt     3000

agaactcatt attctgggta ccctccaatg agaattagag aggttaaata ccttttccta     3060

gattcccaca gcaggaaggt ggcatagctg ttttgtctga caccagaacc catctcacca     3120

cactgcttta cagtcttcct gaaggacatt ttgaggtggg ggggccttca aagctcagag     3180

actggtttga atggtttaat tttgcaatgg atcatgtcca tgccaggtgt tacaattctt     3240

aacttcctcc aaattcgtgt gtccattaga catttggcta catctggctg gaggtcagga     3300

gaaaattctg aggtaaatag atggatttta tctggcagtg tcgaaaatag taggagccta     3360

aaactttgtt caatgagtaa gatgtagatt tggagtcatc agcaggggaa acttgttaga     3420

tgtcctttgt atctttttct atccatttgt attttttctt tcccaaagag ctgaaatcat     3480

tttataccct gaatttaaaa ggtaattgct tttttcctcc ttgcgaaatc ataccttaat     3540

tttttttttt ttttttttta ccatttatga tttattctcc tatgtgtcat atgaaaggcc     3600

aaggggcttt atcttttact agtaggcaag cctgggcatt tctgcatttg tgccagctaa     3660

cactacaaaa tagacttaat tagagaaatt tagacccaga attgcagctt caacaacaca     3720

aaacaggaaa gctagaagag gttgctgtgt caacctacaa gatagtgatt cttggaagtt     3780

ggtatggacc agaaagcatt cccaggacat ttaggctatg gctgagttct ctaagactca     3840

gggtgggaat tataatccct ggtctaagct gatatgaaag tttctatgtg tgaaaatatg     3900

gagttatatg ctttgagatt ttctgccagt taaactaaaa caagatcata ctgtaaatgt     3960

ttgtaacttg cttcccccca ctgtatactg taaacatctt tgcatgtcaa taaatatgcc     4020

tctacaacat atttttgaat cacttaatat ttttcccatg ttaacagttg gtatatagtg     4080

ttgtaaacct ttattgcata ttctcataac atacaatata cacattcttt tgcaaaaatg     4140

ggaacacagt attgagactt gccttttcct cttaacactt atcttttcaa tttagtatta     4200

tatagatctg tcacatgctt tttatctaat aactttatag aaatataatt gccatacatt     4260

aagctgcatg ttgaaagtat acagtgtgat cagttttgga atgtatatac acacaaaacc     4320

ataaccacaa tcaaaattgt aaatacattc atcacccacc aaagctactt tttttttgag     4380

acagagtctt gctctgtcac ccaggctgga gtacagtggc gcaatctcgg cccactgcaa     4440

cctctgcttc ccaggttcaa gtgattctcg tgccttagcc tcctgagcag ctgggactac     4500

aggtgcatgc caccacatcc gactaatttt tttttttatt ttttgtattt ttagtagaga     4560

cagggtttca ccatgttggc caggctggtc ttgaactcct ggtctcaagt gatctaccca     4620

tcttggtctc cctgagtgcc aggattacag gcgtgagcca ccatgcccag cctcccccaa     4680

agcttcttaa tgcccttttg taatccctcc ctcccctctc tccctgtgcc cctaacccag     4740

gcaaccatgg gacattttct gacaaaatag aattgttttc atttcctgta attgtgtata     4800

aatggactca tatagcatgt actctttggt cgggagggga tctggcttat ttcacttagt     4860

gtaattattt gagattcatc catatcatgt gtctcactat ttcattgctt tttattgcca     4920

agtagtattc caccatatgg ctttaccaca gtttatttat ccattcactt attgatggac     4980

atttgggctg ttcagagttt ggccattata agtaaagcag ctatgagcat ttgtgtacaa     5040

gtgtttttat ggacataggc tttcatatct ttggaatgac atctaacaat attgaatctt     5100

cgacccatga ataaaatctc tctccactta                                      5130


<210> 1811
<211> 2322
<212> DNA
<213> Homo sapiens

<400> 1811
ttgtggcaag attctgaggg gaagtgtagc tcccaggttg gttccaagtc ttcttccaat       60

taggatctta tccaggacgc ttcattgcat ttggtcttca tttctcctta gtctcctcca      120

ggctgacatt tcctcaatct ttattggtct tccacagccc tgacactttt ggagatacca      180

gtcagcattt ccaagttcgt tctgtgagac tgtagtgtca ggacaaagca acaacaaaat      240

gtgctctact ctaaagaagt gtgggacata cagaactgaa gttgcagaat gccatgacca      300

tggtagcact tttcaaggaa gaaagaaagg tgggagttct ttccgggata attttgacaa      360

gaggagctgt cattatgaac atggtgggta tgagcgcccg ccttcacact gccaggagaa      420

tgatggaagc gtggagatga gggatgtcca caaggaccaa caactaagac acactcctta      480

tagcatccga tgcgaaagaa gaatgaaatg gcatagtgaa gacgaaatcc gtattaccac      540

gtggagaaat agaaaacctc cggagagaaa aatgagtcag aacacacagg atggatacac      600

aaggaactgg tttaaggtca caattcctta cgggataaag tatgacaagg catggctaat      660

gaattcaatc cagagccatt gcagtgaccg cttcactccg gttgatttcc actacgtccg      720

aaatcgggca tgcttctttg tccaggatgc tagcgctgcc tccgcattga aggatgtcag      780

ttataagatt tatgatgatg agaaccaaaa gatatgtata tttgtcaatc attctactgc      840

gccctactct gtgaagaata agttgaagcc aggccaaatg gagatgctaa agctgaccat      900

gaacaaacgg tacaatgtct cccagcaagc tcttgatctc cagaatctcc gctttgaccc      960

agacttgatg ggccgtgaca ttgatataat cctgaatcga agaaactgca tggctgccac     1020

cctgaagatc attgaaagaa atttccctga gctgttgtct ttgaacttgt gcaacaacaa     1080

gctgtaccag ctggatggcc tttctgacat tacagagaag gctcccaaag tcaagaccct     1140

gaatctctcc aaaaataagc tggagtcggc gtgggagttg ggcaaggtga aagggctgaa     1200

gctcgaagag ctatggctag aagggaaccc gttgtgcagc accttctcgg accagtccgc     1260

ctatgtaagt gccatccggg attgtttccc caagttgtta cgcctggacg gccgagagtt     1320

atccgcacca gtgattgttg acattgacag ctctgagaca atgaaaccct gcaaggaaaa     1380

ctttactgga tctgagaccc taaagcattt agtcctgcaa ttcctgcagc agtattactc     1440

gatctatgac tctggagatc gacagggtct cctcggtgct taccacgatg aggcctgctt     1500

ctccttggct attcccttcg accccaagga ctcagccccg agcagcttgt gcaagtactt     1560

tgaggatagc aggaatatga aaacactcaa ggacccctac ctgaaggggg aactgctgag     1620

gcgcacaaaa cgtgacattg tggactccct cagtgcgttg cccaaaactc agcatgacct     1680

cagctccatc ctggtggacg tgtggtgcca gacggaaagg atgctctgct tttctgtcaa     1740

tggggttttc aaggaagtgg aaggacagtc tcagggttct gttctcgcct tcacccggac     1800

cttcattgct acccctggca gcagttccag tctgtgcatc gtgaatgacg agctgtttgt     1860

gagggatgcc agcccccaag agactcagag tgccttctcc atcccagtgt ccacactctc     1920

ctccagctct gagccctccc tctcccagga gcagcaggaa atggtgcagg ctttctctgc     1980

ccagtctggg atgaaactgg agtggtctca gaagtgcctt caggacaatg agtggaacta     2040

cactagagct ggccaggcct tcactatgct ccagaccgag ggcaagatcc ccgcggaggc     2100

cttcaagcaa atctcctaaa aggagccctc cgatgtcttc tttgtcttcg ttcacatcct     2160

ctttgtttcc tcttttcacc agcctaaggc ctggctgacc aggaagccaa cgttaacttg     2220

caggccacgt gacataacca cccaaagagc cagttgctct gtgtattcgc cccactcatg     2280

atcaccattt tattttcata ataaagagtg acgttacacg tt                        2322


<210> 1812
<211> 2884
<212> DNA
<213> Homo sapiens

<400> 1812
cctcctcctc tgggatcttg aaaacgtaga attcccagag actctgctga tggacagaat       60

ccggctccag gaactggcat tccagttgca ccagttaact gtcctggcct cagtcttgct      120

agtggccaga agcttctctg gtgaagtttt attcagatca cctgaatttg tggatagact      180

gaaatgcacc accaaggccc taactgagga atttatctcc aggcctgaag agactatgct      240

gagtgtgagt gaacaggtgt ctcaggaagt ccatcaaggc cttaaggaca tgggcctcac      300

tactctgagc agtgaaaaca cagcatctct tctaggccaa ctccagaaca tcaccaagaa      360

agagaactgc attcgtagca ttgttggagt ctctgctaca ctttcctgga ggcctcattc      420

tcattgaaaa ggagttggca gaactgggct ggaagtttct caatctgatg catcataatc      480

agcagagtca tttttcacaa aacgaaatct ttccagaaga tcacgaataa gagagatcaa      540

agctaggcag cttgagttga agtagagctg gaagaaggag ttttgaggac tgtttcaaaa      600

ccactggact agatgatctc taaaggatct tatccaggac gcttcattgc atttggtctt      660

catttctcct tagtctcctc caggctgaca tttcctcaat ctttattggt cttccacagc      720

cctgacactt ttggagatac cagtcagcat ttccaagttc gttctgtgag actgtagtgt      780

caggacaaag caacaacaaa atgtgctcta ctctaaagaa gtgtgggaca tacagaactg      840

aagttgcaga atgccatgac catggtagca cttttcaagg aagaaagaaa ggtgggagtt      900

ctttccggga taattttgac aagaggagct gtcattatga acatggtggg tatgagcgcc      960

cgccttcaca ctgccaggag aatgatggaa gcgtggagat gagggatgtc cacaaggacc     1020

aacaactaag acacactcct tatagcatcc gatgcgaaag aagaatgaaa tggcatagtg     1080

aagacgaaat ccgtattacc acgtggagaa atagaaaacc tccggagaga aaaatgagtc     1140

agaacacaca ggatggatac acaaggaact ggtttaaggt cacaattcct tacgggataa     1200

agtatgacaa ggcatggcta atgaattcaa tccagagcca ttgcagtgac cgcttcactc     1260

cggttgattt ccactacgtc cgaaatcggg catgcttctt tgtccaggat gctagcgctg     1320

cctccgcatt gaaggatgtc agttataaga tttatgatga tgagaaccaa aagatatgta     1380

tatttgtcaa tcattctact gcgccctact ctgtgaagaa taagttgaag ccaggccaaa     1440

tggagatgct aaagctgacc atgaacaaac ggtacaatgt ctcccagcaa gctcttgatc     1500

tccagaatct ccgctttgac ccagacttga tgggccgtga cattgatata atcctgaatc     1560

gaagaaactg catggctgcc accctgaaga tcattgaaag aaatttccct gagctgttgt     1620

ctttgaactt gtgcaacaac aagctgtacc agctggatgg cctttctgac attacagaga     1680

aggctcccaa agtcaagacc ctgaatctct ccaaaaataa gctggagtcg gcgtgggagt     1740

tgggcaaggt gaaagggctg aagctcgaag agctatggct agaagggaac ccgttgtgca     1800

gcaccttctc ggaccagtcc gcctatgtaa gtgccatccg ggattgtttc cccaagttgt     1860

tacgcctgga cggccgagag ttatccgcac cagtgattgt tgacattgac agctctgaga     1920

caatgaaacc ctgcaaggaa aactttactg gatctgagac cctaaagcat ttagtcctgc     1980

aattcctgca gcagtattac tcgatctatg actctggaga tcgacagggt ctcctcggtg     2040

cttaccacga tgaggcctgc ttctccttgg ctattccctt cgaccccaag gactcagccc     2100

cgagcagctt gtgcaagtac tttgaggata gcaggaatat gaaaacactc aaggacccct     2160

acctgaaggg ggaactgctg aggcgcacaa aacgtgacat tgtggactcc ctcagtgcgt     2220

tgcccaaaac tcagcatgac ctcagctcca tcctggtgga cgtgtggtgc cagacggaaa     2280

ggatgctctg cttttctgtc aatggggttt tcaaggaagt ggaaggacag tctcagggtt     2340

ctgttctcgc cttcacccgg accttcattg ctacccctgg cagcagttcc agtctgtgca     2400

tcgtgaatga cgagctgttt gtgagggatg ccagccccca agagactcag agtgccttct     2460

ccatcccagt gtccacactc tcctccagct ctgagccctc cctctcccag gagcagcagg     2520

aaatggtgca ggctttctct gcccagtctg ggatgaaact ggagtggtct cagaagtgcc     2580

ttcaggacaa tgagtggaac tacactagag ctggccaggc cttcactatg ctccagaccg     2640

agggcaagat ccccgcggag gccttcaagc aaatctccta aaaggagccc tccgatgtct     2700

tctttgtctt cgttcacatc ctctttgttt cctcttttca ccagcctaag gcctggctga     2760

ccaggaagcc aacgttaact tgcaggccac gtgacataac cacccaaaga gccagttgct     2820

ctgtgtattc gccccactca tgatcaccat tttattttca taataaagag tgacgttaca     2880

cgtt                                                                  2884


<210> 1813
<211> 3193
<212> DNA
<213> Homo sapiens

<400> 1813
cctgactcac ctagctcctc ctgcagcatg gcgtgttcac ttccaagcgg ggcagactct       60

gctgatggac agaatccggc tccaggaact ggcattccag ttgcaccagt taactgtcct      120

ggcctcagtc ttgctagtgg ccagaagctt ctctggtgaa gttttattca gatcacctga      180

atttgtggat agactgaaat gcaccaccaa ggccctaact gaggaattta tctccaggcc      240

tgaagagact atgctgagtg tgagtgaaca ggtgtctcag gaagtccatc aaggccttaa      300

ggacatgggc ctcactactc tgagcagtga aaacacagca tctcttctag gccaactcca      360

gaacatcacc aagaaagaga actgcattcg tagcattgtt gatcagtgga tccgtttttt      420

tctcaaatgc tgtttgcttc atggcatgca ggagtctctg ctacactttc ctggaggcct      480

cattctcatt gaaaaggagt tggcagaact gggctggaag tttctcaatc tgatgcatca      540

taatcagcag agtcattttt cacaaaacga aatctttcca gaagatcacg aataagagag      600

atcaaagcta ggcagcttga gttgaagtag agctggaaga aggagttttg aggactgttt      660

caaaaccact ggactagatg atctctaaag tggtgacatg gacataggat aatggttata      720

gacagtcccc ctcccaacgg gaaaaaatga aagcaagcaa aaagttacca gctccaagcc      780

aacttgaaat ccaatcagga tcttatccag gacgcttcat tgcatttggt cttcatttct      840

ccttagtctc ctccaggctg acatttcctc aatctttatt ggtcttccac agccctgaca      900

cttttggaga taccagtcag catttccaag ttcgttctgt gagactgtag tgtcaggaca      960

aagcaacaac aaaatgtgct ctactctaaa gaagtgtggg acatacagaa ctgaagggat     1020

gatgcttcct gtctgtcaca aggctgagtg aacacaacat gcctgtaggt ccagaacatt     1080

cttcctacag agaccagatg tccagaaagc cctatctgct ggattcaggg aacgcctctc     1140

ctcatttctg tcagcactat ttgcaaaagc ctccttctct gagatcttca aagctgcagt     1200

tctagccaca gtctgcaggg agttgcagaa tgccatgacc atggtagcac ttttcaagga     1260

agaaagaaag gtgggagttc tttccgggat aattttgaca agaggagctg tcattatgaa     1320

catggtgggt atgagcgccc gccttcacac tgccaggaga atgatggaag cgtggagatg     1380

agggatgtcc acaaggacca acaactaaga cagtaagtga ccaggcagcc tggtttgcac     1440

gtagcagccc ccgggactgt gcaacccttt cattctctgt ggtcttcctt ttcttctctc     1500

attagagaac tgacgaatgc tggaagtgga atagtggctg agcagtccta attgtagccc     1560

tggcgtcagt gagtggagca tgtataggag actttcttag atttaatgga tacccgcctt     1620

ctctcctctt ccccacagca ctccttatag catccgatgc gaaagaagaa tgaaatggca     1680

tagtgaagac gaaatccgta ttaccacgtg gagaaataga aaacctccgg agagaaaaat     1740

gagtcagaac acacaggatg gatacacaag gaactggttt aaggtcacaa ttccttacgg     1800

gataaagtat gacaaggcat ggctaatgaa ttcaatccag agccattgca gtgaccgctt     1860

cactccggtt gatttccact acgtccgaaa tcgggcatgc ttctttgtcc aggatgctag     1920

cgctgcctcc gcattgaagg atgtcagtta taagatttat gatgatgaga accaaaagat     1980

atgtatattt gtcaatcatt ctactgcgcc ctactctgtg aagaataagt tgaagccagg     2040

ccaaatggag atgctaaagc tgaccatgaa caaacggtac aatgtctccc agcaagctct     2100

tgatctccag aatctccgct ttgacccaga cttgatgggc cgtgacattg atataatcct     2160

gaatcgaaga aactgcatgg ctgccaccct gaagatcatt gaaagaaatt tccctgagct     2220

gttgtctttg aacttgtgca acaacaagct gtaccagctg gatggccttt ctgacattac     2280

agagaaggct cccaaagtca agaccctgaa tctctccaaa aataagctgg agtcggcgtg     2340

ggagttgggc aaggtgaaag ggctgaagct cgaagagcta tggctagaag ggaacccgtt     2400

gtgcagcacc ttctcggacc agtccgccta tgtaagtgcc atccgggatt gtttccccaa     2460

gttgttacgc ctggacggcc gagagttatc cgcaccagtg attgttgaca ttgacagctc     2520

tgagacaatg aaaccctgca aggaaaactt tactggatct gagaccctaa agcatttagt     2580

cctgcaattc ctgcagcagt attactcgat ctatgactct ggagatcgac agggtctcct     2640

cggtgcttac cacgatgagg cctgcttctc cttggctatt cccttcgacc ccaaggactc     2700

agccccgagc agcttgtgca agtactttga ggatagcagg aatatgaaaa cactcaagga     2760

cccctacctg aagggggaac tgctgaggcg cacaaaacgt gacattgtgg actccctcag     2820

tgcgttgccc aaaactcagc atgacctcag ctccatcctg gtggacgtgt ggtgccagac     2880

ggtgccttca ggacaatgag tggaactaca ctagagctgg ccaggccttc actatgctcc     2940

agaccgaggg caagatcccc gcggaggcct tcaagcaaat ctcctaaaag gagccctccg     3000

atgtcttctt tgtcttcgtt cacatcctct ttgtttcctc ttttcaccag cctaaggcct     3060

ggctgaccag gaagccaacg ttaacttgca ggccacgtga cataaccacc caaagagcca     3120

gttgctctgt gtattcgccc cactcatgat caccatttta ttttcataat aaagagtgac     3180

gttacacgtt gta                                                        3193


<210> 1814
<211> 2034
<212> DNA
<213> Homo sapiens

<400> 1814
gcagactgcc ataagatggc gtccgtggcg gctgcacgag cagttcccgt gggcagtggg       60

ctcaggggcc tgcaacggac cctacctctt gtagtgattc tcggggccac gggcaccggc      120

aaatccacgc tggcgttgca gctaggccag cggctcggcg gtgagatcgt cagcgctgac      180

tccatgcagg tctatgaagg cctagacatc atcaccaaca aggtttctgc ccaagagcag      240

agaatctgcc ggcaccacat gatcagcttt gtggatcctc ttgtgaccaa ttacacagtg      300

gtggacttca gaaatagagc aactgctctg attgaagata tatttgcccg agacaaaatt      360

cctattgttg tgggaggaac caattattac attgaatctc tgctctggaa agttcttgtc      420

aataccaagc cccaggagat gggcactgag aaagtgattg accgaaaagt ggagcttgaa      480

aaggaggatg gtcttgtact tcacaaacgc ctaagccagg tggacccaga aatggctgcc      540

aagctgcatc cacatgacaa acgcaaagtg gccaggagct tgcaagtttt tgaagaaaca      600

ggaatctctc atagtgaatt tctccatcgt caacatacgg aagaaggtgg tggtcccctt      660

ggaggtcctc tgaagttctc taacccttgc atcctttggc ttcatgctga ccaggcagtt      720

ctagatgagc gcttggataa gagggtggat gacatgcttg ctgctgggct cttggaggaa      780

ctaagagatt ttcacagacg ctataatcag aagaatgttt cggaaaatag ccaggactat      840

caacatggta tcttccaatc aattggcttc aaggaatttc acgagtacct gatcactgag      900

ggaaaatgca cactggagac tagtaaccag cttctaaaga aaggacctgg tcccattgtc      960

ccccctgtct atggcttaga ggtatctgat gtctcgaagt gggaagagtc tgttcttgaa     1020

cctgctcttg aaatcgtgca aagtttcatc cagggccaca agcctacagc cactccaata     1080

aagatgccat acaatgaagc tgagaacaag agaagttatc acctgtgtga cctctgtgat     1140

cgaatcatca ttggggatcg cgaatgggca gcgcacataa aatccaaatc ccacttgaac     1200

caactgaaga aaagaagaag attggactca gatgctgtca acaccataga aagtcagagt     1260

gtttccccag accataacaa agaacctaaa gagaagggat ccccagggca gaatgatcaa     1320

gagctgaaat gcagcgttta agagacatgt ccagtggcct ttggaaaggt ggtggggatc     1380

cagttcagga gggaggggta tgtttgtctc ccagtctggg caaaggagtg ctatgcggaa     1440

ttctctgcat agcagaaaag ctcccaccat tttcttttga tgtggtttta aagtctcacg     1500

ttctctataa tagaaacagc aggtcttgtc agctccttgt gtggctgatg tgtctggaaa     1560

tgatgtagtt caggaaagca tttttttttt ctttgaacct taaaggttct attattaaaa     1620

gcagcacaga ttccacattt ttatacatga ggatcttctt tgtggtgaat accaggattg     1680

actgcatccc tttaaagaag ttttatgtcc ctgactctgg ctaaaattat ctaatttcca     1740

gatgcttttg tagatgactg aagtatttgt gagccacata ttgggagttc tagatttgag     1800

tgaatggcag gaaagggcca tctccattga gatgattaag tgaaccaaac tagttctcag     1860

aattctacag agaaggaggg aatcagactg aggaagctgt gacataggac ttgaagacca     1920

aagactttga aatttgcgag ctgctcatgt gtgagttatt atcactgctg tctttctatt     1980

gagttacaaa tctatatttt tattgaagtt taaataaaga aaaaatttac aaga           2034


<210> 1815
<211> 1880
<212> DNA
<213> Homo sapiens

<400> 1815
cagactgcca taagatggcg tccgtggcgg ctgcacgagc agttcccgtg ggcagtgggc       60

tcaggggcct gcaacggacc ctacctcttg tagtgattct cggggccacg ggcaccggca      120

aatccacgct ggcgttgcag ctaggccagc ggctcggcgg tgagatcgtc agcgctgact      180

ccatgcagcc ccaggagatg ggcactgaga aagtgattga ccgaaaagtg gagcttgaaa      240

aggaggatgg tcttgtactt cacaaacgcc taagccaggt ggacccagaa atggctgcca      300

agctgcatcc acatgacaaa cgcaaagtgg ccaggagctt gcaagttttt gaagaaacag      360

gaatctctca tagtgaattt ctccatcgtc aacatacgga agaaggtggt ggtccccttg      420

gaggtcctct gaagttctct aacccttgca tcctttggct tcatgctgac caggcagatg      480

agcgcttgga taagagggtg gatgacatgc ttgctgctgg gctcttggag gaactaagag      540

attttcacag acgctataat cagaagaatg tttcggaaaa tagccaggac tatcaacatg      600

gtatcttcca atcaattggc ttcaaggaat ttcacgagta cctgatcact gagggaaaat      660

gcacactgga gactagtaac cagcttctaa agaaaggtat tgaggctctg aaacaagtaa      720

ctaagagata tgcccggaaa caaaaccgat gggttaaaaa ccgttttttg agcagacctg      780

gtcccattgt cccccctgtc tatggcttag aggtatctga tgtctcgaag tgggaagagt      840

ctgttcttga acctgctctt gaaatcgtgc aaagtttcat ccagggccac aagcctacag      900

ccactccaat aaagatgcca tacaatgaag ctgagaacaa gagaagttat cacctgtgtg      960

acctctgtga tcgaatcatc attggggatc gcgaatgggc agcgcacata aaatccaaat     1020

cccacttgaa ccaactgaag aaaagaagaa gattggactc agatgctgtc aacaccatag     1080

aaagtcagag tgtttcccca gaccataaca aagaacctaa agagaaggga tccccagggc     1140

agaatgatca agagctgaaa tgcagcgttt aagagacatg tccagtggcc tttggaaagg     1200

tggtggggat ccagttcagg agggaggggt atgtttgtct cccagtctgg gcaaaggagt     1260

gctatgcgga attctctgca tagcagaaaa gctcccacca ttttcttttg atgtggtttt     1320

aaagtctcac gttctctata atagaaacag caggtcttgt cagctccttg tgtggctgat     1380

gtgtctggaa atgatgtagt tcaggaaagc attttttttt tctttgaacc ttaaaggttc     1440

tattattaaa agcagcacag attccacatt tttatacatg aggatcttct ttgtggtgaa     1500

taccaggatt gactgcatcc ctttaaagaa gttttatgtc cctgactctg gctaaaatta     1560

tctaatttcc agatgctttt gtagatgact gaagtatttg tgagccacat attgggagtt     1620

ctagatttga gtgaatggca ggaaagggcc atctccattg agatgattaa gtgaaccaaa     1680

ctagttctca gaattctaca gagaaggagg gaatcagact gaggaagctg tgacatagga     1740

cttgaagacc aaagactttg aaatttgcga gctgctcatg tgtgagttat tatcactgct     1800

gtctttctat tgagttacaa atctatattt ttattgaagt ttaaataaag aaaaaattta     1860

caagagcctc tttgatcctt                                                 1880


<210> 1816
<211> 3661
<212> DNA
<213> Homo sapiens

<400> 1816
ctcctggctt ccccgcgggg cctcccaggg cacctgccca aggccaccca gcgcgcggca       60

gccgagacag cggagcagag ccggacctcc cagccgtcga tgaaggcggc gaccgcctag      120

ggccttccca cggctcggcg gcgcgtcacc gcgggggcga gggggcgcct gggcgcccgg      180

agctgcggcg caggaaaggg ccctgggaaa gggcggtggc ggcgcccccg aggcggggcc      240

ggggcggggc cggggcgggg cctgacttcc cgactgggag ccttagccgc ggggctgaga      300

ccaggcagcc tgcgttcgcc atgaagcgac ccaaggagcc gagcggctcc gacggggagt      360

ccgacggacc catcgacgtg ggccaagagg gccagctgag ccagatggcc aggccgctgt      420

ccacccccag ctcttcgcag atgcaagcca ggaagaaaca cagagggatc atagagaaac      480

ggcgtcgaga ccgcatcaac agtagccttt ctgaattgcg acgcttggtc cccactgcct      540

ttgagaaaca gggctcttcc aagctggaga aagccgaggt cttgcagatg acggtggatc      600

acttgaaaat gctccatgcc actggtggga caggattctt tgatgcccga gccctggcag      660

ttgacttccg gagcattggt tttcgggagt gcctcactga ggtcatcagg tacctggggg      720

tccttgaagg gcccagcagc cgtgcagacc ccgtccggat tcgccttctc tcccacctca      780

acagctacgc agccgagatg gagccttcgc ccacgcccac tggccctttg gccttccctg      840

cctggccctg gtctttcttc catagctgtc cagggctgcc agccctgagc aaccagctcg      900

ccatcctggg aagagtgccc agccctgtcc tccccggtgt ctcctctcct gcttacccca      960

tcccagccct ccgaaccgct ccccttcgca gagccacagg catcatcctg ccagcccgga     1020

ggaatgtgct gcccagtcga ggggcatctt ccacccggag ggcccgcccc ctagagaggc     1080

cagcgacccc tgtgcctgtc gcccccagca gcagggctgc caggagcagc cacatcgctc     1140

ccctcctgca gtcttcctcc ccaacacccc ctggtcctac agggtcggct gcttacgtgg     1200

ctgttcccac ccccaactca tcctccccag ggccagctgg gaggccagcg ggagccatgc     1260

tctaccactc ctgggtctct gaaatcactg aaatcggggc tttctgagct gccccttcac     1320

caccccgccc caaggaataa ggaaggttct tttaccagga gcccaaaaaa gggcactgcc     1380

ttttctgctt tgcttcatgg actggctcat atgtgaaggc acgttctcca gccatcagag     1440

gccccctcct cctccaaccc atctctcctt ctcactgtta tcccagctta tccacccagc     1500

tctcctggag ctgttctggt ctcagaggct tggttccatt tctcacctga acagatgagt     1560

cctgggagag accctcagag atccgcccag acccctctcc tgccctctgc acaccagcag     1620

caggcatgaa ccttgggtct gggaaaaagc tttaacctgc agggcaccag gacccaaggc     1680

aggctgttcc ttggggcggt cagaccccag tcaggagcaa tgactgactg gctgcagcct     1740

tcccacgcca agaggctgga acatagtgtc tgcctcgctt cctggagata gtaactgagc     1800

aggggctaca aagaggtctc ctgggaaccc tgtctgcccc ttcccacctg tccttgggcc     1860

acaccatcac actgaaccac aggacagacc ctttctccac cacagccaag gcctggagac     1920

tgggggccca gcagagcctg ctcccaccct cctcccagca gcagacaccc accctctcac     1980

tgactaacag gtccctgcac acagctggcc tggtaaaccc agctgggagg tttctaggca     2040

gcagcaaaac tctgtgacag ggtgtcctca caccaggcct tggacagctc tcccagacag     2100

gagccagggt tgagcaatgg agagcccagc ccccacgtct tacagtcgcc atcctccagg     2160

cgtgtggtcc ctccccattg ggtgcacagt gcagaggggc cgtggcccca tgtgatggtg     2220

cgcagagagg aacctcttgg gattcagcac cagacgtctg tgctgcctgg tttgcatccg     2280

gctcacagag cccagactgc tggaacagcc aaggactgtc aggctggaca aaaataactg     2340

caaggagggg caagagaaag gatgattcga ggcaccttgg cccttcaagg tcatgcagtg     2400

ggtcgagcgc ctgagatcct gttcaccagg actccacaga gctggctctg ctcagaagcc     2460

atttcattcc ccggctccac cctaggccac tttttctaac agaggaaaca aatggtccag     2520

cagtcgttcc cagcagaaca gcggagcctg gactgacacc cagtgggacc agtgttgcca     2580

caccagttga taaaatgcag aaacccttct gtactcgttg gtaaatatct actcccccaa     2640

gtgactccag gtgcccccca ccgcctggca cttcccccag gactcctacg atctggttac     2700

tgcctggccg atccaaggct gtggagtccc agagccagca gttcactggt gctcattcca     2760

cactggttag atacttcagt tgtcacccct gggaagattc tcccacctcc tccctttgat     2820

ggaaccaccc tccccagagg ctgcattgag gagactccac agactgaaaa gtgagtttgc     2880

agaaaccttg gggaaaaggg ccctttcaaa gaagtggata agagggagga gatcattgag     2940

tgacccagaa agctcttttg aaaagacaga ctcctcaagg agagataaag aggaaagcac     3000

ctctttcatt ttttagtgtg agctaattcc atcagactgc tgtcctcctg gacccatctg     3060

agatgtgcag tagcaaggag aggggggatc attttagaga gtgggtcatt ggcagggagt     3120

gctccggagg gaggcagagg ggagactgtg gtagaaggaa gacagaactc acacatgctc     3180

ccaggattgg ggacagggac agaggaggta acagaaggca aaggccagtt tccccgttat     3240

catgaagggg cccactcagg acaggaacaa ggacaactcc tcctcctcct cctcctctcc     3300

tgctgctcct gggataccag gtcagtgatg tagtcttgca gtttggcaac ttcctagcct     3360

gagaatccct agtggggctg tgggaaacac atttccacgt tgcaagcatg caactccaaa     3420

gaatctgtga tgccactgaa atgagatggg aatgatccag ctctttcagc atcttggttg     3480

aacttgcttt cattgtccct gggatattgt ggaaggaaag gtgactgtgt gatctgattc     3540

tgtggtcaag gacttgcatc ttgtgtttct atccccaagc cttcctggtg tctccaactc     3600

ctaccccatt gcatgggttg ttgcggacat ccaataaaga tttttttagt gcttctggaa     3660

a                                                                     3661


<210> 1817
<211> 4121
<212> DNA
<213> Homo sapiens

<400> 1817
agccaacacc gcctttctca gcatggagac ctttgagccc atcagccaag agcccctcag       60

ccaagccagc tatgacaaag ccccagaccc agttcctgag ctccaagact cgttctatgc      120

agaactgcaa cgtgcagaga gcctccaaga gaagagcata aaagaggcca agaccaaatg      180

caggacaatt gcatccctgc tcactgcagc ccccaacccc cactccaaag gggtacttat      240

gtttaagaaa cggcggcaga gagccaagaa gtacaccctg gtgagcttcg gggctgctgc      300

tgggacaggc gctgaggagg aggacggcgt tccccccacg agtgagtccg agctggacga      360

agaagccttc tctgacgccc gcagcctcac caatcaatct gactgggaca gtccctatct      420

ggacatggag cttgccaggg cgggctcaag agcatcagag ggccagggct ctgggctggg      480

agggcagctg agtgaggtct ctgggcgagg ggtgcagctc tttgaacagc agcgccagcg      540

cgcagactcc agcacccagg aactggcacg ggtcgaacca gcagccatgc tcaacgggga      600

aggcctgcag tcaccacctc gggcccagag tgctccccca gaggcagctg tgctcccacc      660

cagccccttg ccggcgcctg tagccagccc cagacccttc caaccaggtg gtggagcccc      720

gaccccagct ccaagcatct ttaaccggtc agccaggccc tttaccccgg gcctacaagg      780

gcagcggcca actaccacct cggttatttt ccggccttta gcccccaaaa gggcgaacga      840

cagcctgggg ggcctcagcc ccgccccacc ccccttcttg tcttcgcagg ggcccacccc      900

tctgcccagc ttcacttcag gggttcccag ccacgcgcca gtctctggtt cccccagcac      960

cccacgctcc tcgggccctg tgacagccac cagctccctg tacatcccag cccctagtcg     1020

gcctgtcacc ccaggtggag ctccagagcc ccccgctcct cctagcgcag ctgccatgac     1080

ctccaccgct tctatcttcc tatctgcgcc tttgcgaccc tctgcgcgcc cagaggcgcc     1140

tgccccaggc ccaggggctc ctgagccccc cagcgctcgc gagcagcgca tctctgtgcc     1200

agctgcccgc acgggtatcc tgcaggaggc ccggcgccgg gggacccgga agcagatgtt     1260

ccggccggga aaggaggaga cgaagaactc gcccaacccc gagctgctat cgctggtaca     1320

gaacctggat gaaaagcctc gggccggggg tgcagaatct ggtcctgaag aagatgctct     1380

gagcctcggg gctgaagcct gcaacttcat gcagccagta ggggccagga gttacaagac     1440

cctgcctcac gtgacaccta agaccccccc tccaatggct cccaagaccc cgccccctat     1500

gactcctaag actccacccc cagtggctcc taagccccca tctcgagggc tccttgatgg     1560

gctcgtgaat ggggcagcct cttcggctgg aatccctgag ccaccaaggc tgcagggcag     1620

gggtggggag ctgtttgcta agcggcagag ccgtgcggac aggtatgtgg tggaaggtac     1680

acctggtcct ggtcttggcc ctcggcctag aagtccttct cctaccccgt ctctgccccc     1740

ttcctggaaa tattcaccca acatccgtgc cccgcctcct attgcttaca acccactgct     1800

ctctcccttt ttcccccagg cggcccgaac tctccctaag gcccaatccc aggggcctcg     1860

ggcaacaccc aagcagggca tcaaggctct agattttatg cggcatcagc cctatcaact     1920

taaaactgcc atgttctgtt ttgatgaggt tcccccgact cctggcccta tcgcctcagg     1980

gtcccccaaa actgcccgag tccaggagat tcgccggttt tccactccgg caccccagcc     2040

cactgcagaa cccctggctc ccactgtgct tgccccccga gcagccacta cactggatga     2100

gcccatctgg agaacagaac tggcctcagc ccctgttcct agcccagccc ctcctccaga     2160

ggctcccagg ggccttgggg cttctcccag ctcctgcggt ttccaggtag ccaggccccg     2220

attttcagcc accagaacag gattgcaagc tcatgtgtgg aggcctgggg cagggcacca     2280

gtgaacaggc acaggtccca ggaccaagga gaggtggaac atccagttcc taaagttgct     2340

tctcctaccc tatcccatcc cctgtcacgc atctggaagc taaattgcct cctgccagag     2400

atggtttcca agttgatgtc cccttccccc accttcctcc tcactctcta cctccctgcc     2460

gctttccaac caagtatgtc tgctttggta tctttgcctc tctttgtctc tgcatttcct     2520

ttcctggatc tctgtcttta tttccaggct tctccaccca tattcctcca cagatctctc     2580

ttccttgaca tttgtgcttt tctccctggg cctcatttta atgttcagtg agaagtaaac     2640

agagcagaag tgaccactgg gacttcaggc aagaagctca ccaccaggca cacagcaaag     2700

ggactgaact gacccctgtt tgcactaagc cacccccacc ccccactctg ctttcccaag     2760

cttgactggc atatacctag gcctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     2820

gtgctcttcc gtctaaggca tgaataagag gggaggtcaa aataaagacc caatctgagg     2880

ccgggcacgg tggctcacgc cggtaatccc agcactttgg gaggccgagg cgggcggatc     2940

acgaggtcag gagatcgaga ccatcctggc taacacggtg aaaccccatt tccactaaaa     3000

atacaaaaaa ttagctgggc gtggtggcga gcgcctgtag tcccagctac tcgggaggct     3060

gaggcaggag aatggcatga acctggaagg cggagcttgc agtgagctga gattgcgcca     3120

ctgcactcca gcctgggcga cggagcgaga ctctgtctca aaacaaacaa acaaacaaaa     3180

gacccaatct gagtcttatc gttgtactga tagaagggtc agatatcccc acatggagtt     3240

gagtgggaga aagagattca ctagagaata actccttaga gaccaatgtc tgtagcaggt     3300

gtacagcatc ttgtgaaagt tatggagcat gaaaagactg aagggccagg acagtttgca     3360

tgggctgagt tataccagct agaccaggaa tagaacaaag aattctatac ctcaggattt     3420

caaaaagtta gcaacttgag aggccagtgc tgagcaaccc agtacccagg aaatgaaaaa     3480

aagaaagaaa attccctccg agaatgaaca aatcattggc ttcattgcct catgagcttg     3540

agagaaagga gaagagagcc agagtgtggc aagtgaggcc aaaatcagaa gcatggcaga     3600

aatgagtgta agtgattgag ccacagacag aagtgtggcg agggacaatg ccatattggg     3660

agaaggtaaa gttgagtaac aagaaaccaa ccgtgtgtga gagggggatt ggaaaaaaat     3720

ttgagggaga agaatgttag aatggaaggg aatgatggtg gaagggaggt gtgagggtgt     3780

gtgctgagtg ttgaaagaac ggttggtgtc tgtgtgattt tccttgagtc tgttcttcag     3840

tgtgtcttct gcagcttgcc atgactgcct gggaaagagt agggaaatac ccagagccaa     3900

aacctccttt cagtcccacc ccatccctca aaaccccagc tattgcttct tttcagcttc     3960

aggtcctgat ctccaatctt agtatggact cccttctcac caagaccacc accagctacg     4020

tttgctgtgt aatctggaaa gtgataattt cctttgcttg ttgggtgtga gtcacaatac     4080

tttggtttgt gcacaagaat aaatttatgc cccatacctt c                         4121


<210> 1818
<211> 1616
<212> DNA
<213> Homo sapiens

<400> 1818
gagagaggaa gcttgaagcc aatatggagt ccgtcagttg ctccgctgct gctgtcagga       60

ccggagacat ggagtcccag cgggacctga gcctggtgcc tgagcggctt cagagacgcg      120

aacaagaacg gcagctggaa gttgaaaggc ggaaacaaaa gcggcagaac caggaggtag      180

agaaggagaa cagccacttt ttcgtcgcca cctttgttcg ggagcgagcg gccgtggaag      240

agcttctgga gcgcgcggag tcggtcgagc ggctggagga ggcggcctct cggctccagg      300

ggctgcagaa actaatcaac gactcagttt ttttcctagc cgcttacgac ctgcggcagg      360

gacaagaggc gctggcgcgg ctgcaggcgg ccttggccga gcggcgccgg gggctgcagc      420

ccaagaagcg tttcgctttc aagacccggg gaaaggatgc tgcttcgtct accaaagtag      480

acgcggctcc tggcatcccc ccggcagttg aaagcataca ggactccccg ctgcccaaga      540

aggcggaagg agacctcggc cccagctggg tctgcggttt ctccaacctg gagtcccaag      600

tcttggagaa gagagccagc gagttgcacc agcgcgacgt tcttttgacc gaactgagca      660

actgcacggt cagactgtat ggaaatccca acaccctgcg gctaaccaag gcccacagct      720

gcaagctgct ctgcggtccg gtgtctacct ctgttttcct ggaggactgc agtgactgcg      780

tgctggcagt ggcctgccaa cagctccgca tacacagtac gaaagacacc cgcatcttcc      840

tgcaggtgac cagcagggcc atcgtggagg actgcagtgg gatccagttc gccccttaca      900

cctggagcta cccggagatc gacaaggact tcgagagctc tggtttagat aggagcaaaa      960

ataactggaa cgatgttgac gattttaact ggctggcccg ggatatggcc tccccaaact     1020

ggagtattct tcctgaagag gagcgaaata tccagtggga ctaagcagtt gtcactctgt     1080

tcttcactcc taccaaatac tttccacgtt ggactttccc ccttattggg tctcgaagtt     1140

tacttattgt cacactgtgt atgttttcag cattttaagg ctagagattg taatgggctc     1200

ctacttgtaa tttccattaa attcgtaaca ggtataacac taaagcattt ttgctatttt     1260

cgtcatgcct ttgagactga gtcttactcc gtcccccagc gtggtggcgc gctgggatta     1320

caggcgcgcg ccaccacgcg aacttgtatt tttagtagag acggggtttc gccatgttgt     1380

ccgggctgct ctcgaactcc tgacctcagg tgatccaccc gcttcagctt cccaaagtgc     1440

tggcattaca ggcgtgagcc accacgccag ggctttattt atttattttt accacaatag     1500

tttgaagcag taagggggaa ggagggtgat tatattgctt tgtaatggtt tgtgatactt     1560

gaaacatcac ggtgcataat aaagtaggtc tgcagtaaat acatgggttt gtttgg         1616


<210> 1819
<211> 2375
<212> DNA
<213> Homo sapiens

<400> 1819
acagggtctc actgtgtcac ccaggctgga gtgcagtagt gcaatctctg ctcactgcag       60

ccttcacctc ctgggttcaa gtgattctcc tgcctcagcc tcccgagtag ctgggattac      120

aggtgtgtgc caccatgccc aactagtttt tgtatttttt agcagagacg gggtttcctc      180

atattggcca ggctggtctc aaactcctgt acgcctgacc tcaagtcagg cccacctcgg      240

cctcccagag tgctgggatt acagaacata tgcagtaatg tcacctcaaa agagagttaa      300

gaacgtccag gcacaaaaca ggacttcaca aggtagtagt agttttcaga ccacgctttc      360

agcctggaaa gtaaaacagg atccaagcaa ctcgaagaac atctcaaaac atggacaaaa      420

caatccagtg ggagattatg aacatgctga tgatcaagct gaagaagatg ctttgcaaat      480

ggcagtggga tattttgaga aaggtcccat taaagcttca cagaataaag ataaaacctt      540

ggaaaaacac ttgaaaactg tggaaaatgt ggcttggaag aatgggttag cttcagaaga      600

aattgatatt ctattaaata ttgcactcag tggcaaattt ggaaatgctg taaacacacg      660

gatattgaag tgcatgatcc cagcaacagt aatatcagaa gattctgtgg ttaaggcagt      720

ctcctggctt tgtgttggca agtgttctgg tagcaccaag gtactttttt atcgttggct      780

ggttgcaatg tttgacttca ttgatcgtaa ggagcaaatt aacttgctct atggcttctt      840

ttttgcttca ttgcaagatg atgcactgtg cccttatgtt tgccatttgt tatatttact      900

taccaaaaaa gagaatgtca aaccatttcg tgtgagaaaa ctgcttgatc ttcaggccaa      960

aatgggaatg cagcctcatc tccaggcttt gttgtcactg tataagttct ttgctcctgc     1020

tctgatttca gtatctttgc ctgtaaggaa gaagatatat tttaagaatt cagagaatct     1080

atggaagacg gctctgcttg ccgtgaagca aagaaaccgg ggaccttctc cagaacctct     1140

gaagttgatg ttaggtccag ctaatgttcg tcctctaaaa agaaagtgga attctctctc     1200

agttatacca gtgctcaatt ccagtagcta cactaaagaa tgtggaaaaa aagagatgag     1260

tctttctgat tgtctgaata gaagtggatc atttccacta gaacaacttc aaagcttccc     1320

ccaactttta cagaacatcc attgcttaga gctgccttct cagatgggct cagtgctaaa     1380

caactctctg ctgcttcact acattaactg tgtcagagat gagccagtct tgctgaggtt     1440

ttattactgg ttgagtcaaa cattacaaga agaatgtatt tggtacaagg tgaataatta     1500

tgaacatgga aaagaattta ccaacttcct ggataccatc atcagggcag agtgcttctt     1560

acaagagggg ttttattcct gtgaagcatt cctgtataag agccttcctc tctgggatgg     1620

cctttgttgt cggtcacagt tccttcagct tgtgagctgg attcctttta gtagcttctc     1680

tgaggtgaaa ccacttcttt ttgaccatct agcgcagctc ttctttacat caaccattta     1740

tttcaagtgt agtgtgcttc agagtctgaa agagctattg cagaattggc tgttgtggct     1800

ttctatggac attcacatga aacctgttac aaacagtcct ctgtgagtta tctaacggtc     1860

ttccacaaga gacgatctgt atacaaatgt ttgcatatgt ttaatagtgt ggcgtgaaac     1920

aatttttttc atgtaaatgc ttagtagtac ttttttggaa gacttttttg tgacttttca     1980

ctcttcttcc cccacaatcc tgaaaggaag gctaattctc taagttccta ttgtgtaaat     2040

cagaaagcaa cccttatctg ctaaatgact tctttcaaga gttaatataa caaaacacta     2100

gagagatgag actagaattt gcaactttga cttccattca gtttaactca ttttataaat     2160

tatattctta tatttaaagc caattttcat gatggctaga aaaatctcta acgtaatttt     2220

gcgtacaact ttgtttttat gtttctgtgc tgtattttgg ttatatgtgt taatttatct     2280

taactttgga gtttaaaata agagccctaa attgttaaat gtgtgcttta ccttcaaagt     2340

aaaagtaaaa gactaaattt caaggaactg cataa                                2375


<210> 1820
<211> 3262
<212> DNA
<213> Homo sapiens

<400> 1820
acagggtctc actgtgtcac ccaggctgga gtgcagtagt gcaatctctg ctcactgcag       60

ccttcacctc ctgggttcaa gtgattctcc tgcctcagcc tcccgagtag ctgggattac      120

aggtgtgtgc caccatgccc aactagtttt tgtatttttt agcagagacg gggtttcctc      180

atattggcca ggctggtctc aaactcctgt acgcctgacc tcaagtcagg cccacctcgg      240

cctcccagag tgctgggatt acagaacata tgcagtaatg tcacctcaaa agagagttaa      300

gaacgtccag gcacaaaaca ggacttcaca aggtagtagt agttttcaga ccacgctttc      360

agcctggaaa gtaaaacagg atccaagcaa ctcgaagaac atctcaaaac atggacaaaa      420

caatccagtg ggagattatg aacatgctga tgatcaagct gaagaagatg ctttgcaaat      480

ggcagtggga tattttgaga aaggtcccat taaagcttca cagaataaag ataaaacctt      540

ggaaaaacac ttgaaaactg tggaaaatgt ggcttggaag aatgggttag cttcagaaga      600

aattgatatt ctattaaata ttgcactcag tggcaaattt ggaaatgctg taaacacacg      660

gatattgaag tgcatgatcc cagcaacagt aatatcagaa gattctgtgg ttaaggcagt      720

ctcctggctt tgtgttggca agtgttctgg tagcaccaag gtactttttt atcgttggct      780

ggttgcaatg tttgacttca ttgatcgtaa ggagcaaatt aacttgctct atggcttctt      840

ttttgcttca ttgcaagatg atgcactgtg cccttatgtt tgccatttgt tatatttact      900

taccaaaaaa gagaatgtca aaccatttcg tgtgagaaaa ctgcttgatc ttcaggccaa      960

aatgggaatg cagcctcatc tccaggcttt gttgtcactg tataagttct ttgctcctgc     1020

tctgatttca gtatctttgc ctgtaaggaa gaagatatat tttaagaatt cagagaatct     1080

atggaagacg gctctgcttg ccgtgaagca aagaaaccgg ggaccttctc cagaacctct     1140

gaagttgatg ttaggtccag ctaatgttcg tcctctaaaa agaaagtgga attctctctc     1200

agttatacca gtgctcaatt ccagtagcta cactaaagaa tgtggaaaaa aagagatgag     1260

tctttctgat tgtctgaata gaagtggatc atttccacta gaacaacttc aaagcttccc     1320

ccaactttta cagaacatcc attgcttaga gctgccttct cagatgggct cagtgctaaa     1380

caactctctg ctgcttcact acattaactg tgtcagagat gagccagtct tgctgaggtt     1440

ttattactgg ttgagtcaaa cattacaaga agaatgtatt tggtacaagg tgaataatta     1500

tgaacatgga aaagaattta ccaacttcct ggataccatc atcagggcag agtgcttctt     1560

acaagagggg ttttattcct gtgaagcatt cctgtataag agccttcctc tctgggatgg     1620

cctttgttgt cggtcacagt tccttcagct tgtgagctgg attcctttta gtagcttctc     1680

tgaggtgaaa ccacttcttt ttgaccatct agcgcagctc ttctttacat caaccattta     1740

tttcaagtgt agtgtgcttc agagtctgaa agagctattg cagaattggc tgttgtggct     1800

ttctatggac attcacatga aacctgttac aaacagtcct ctagagacaa ctttgggtgg     1860

atccatgaac tctgtgtcta aactgatcca ctatgtaggg tggctatcca ctactgcaat     1920

gcgcttggag agcaacaata ctttcttgct gcactttatt ttggatttct atgagaaggt     1980

gtgtgacata tatataaatt ataaccttcc attagtggta ttgtttcctc ctgggatctt     2040

ctattctgca ctcctcagcc tggataccag catcctgaac cagctgtgtt ttattatgca     2100

cagatatcgt aaaaatttga ctgccgcaaa gaaaaatgag ttggtacaaa agacaaaatc     2160

agagttcaat ttcagcagca agacttatca agaatttaat cactatttga catcaatggt     2220

tggttgcctg tggacgtcca aaccctttgg gaaaggaata tatattgacc ctgaaatcct     2280

agaaaaaact ggagtggctg aatataaaaa cagtttaaat gtagtccatc atccttcttt     2340

cttgagttac gctgtttcct ttttgctaca ggaaagccca gaagaaagga cagtaaatgt     2400

gagctctatt cggggaaaga aatggagctg gtatttggac tatttatttt cacaggggtt     2460

acaaggcttg aaacttttta taagaagtag tgttcatcat tcttccattc ccagagcaga     2520

gggcataaac tgcaacaatc aatattaaat gaatgttgac ataaactgaa cacactggac     2580

taaactcact cctcattgct agagcaaagt ggctcatctt gagttcccat tttcatttca     2640

ctgacagact gccatcctca aggagtactc agactggcct tctgttcatg gcttaggaga     2700

gccttggtgt gcctaactga tttttcaaaa tttagatttt tttagcctac cagtgaaaaa     2760

tgaccccttc atcatcaggc tctgcgttct accaaattgt atgtaaaaag acacatctgt     2820

tttgtggtag gattttttca catttttggg tactatgagc tgcattgatg gaagacagca     2880

ggcaatatgt ggtgacagtt aactcacaga cataaacatg caaaatactt tgctgtctct     2940

ggggatattg ccatttttct tactgtgagc aacagcacca acaccaagtt aacaggatgc     3000

aacatgtgta tgactctaaa agccctaagt agttggtaac ttcctgggcc ttcaatcata     3060

gcaatttgat gagggaagga aggggagagg atttgttggg taatcaagac attcccgtat     3120

atgtctgatt tcatggaact gctctatttt gtttgtgtgt attgtatatg tatatgtgta     3180

tgtgtgcgtg tatgtgtgtg tctgtagctt cagtttttaa gtgtaaggac taaataaact     3240

aactgaaatt ttactttcag aa                                              3262


<210> 1821
<211> 6680
<212> DNA
<213> Homo sapiens

<400> 1821
acactacgcc agaacaagat ggccgacgcg gcggccacag ctggggccgg tggctccgga       60

acgagatcgg gaagtaaaca gtccactaac cctgccgata actatcatct ggcccggagg      120

agaaccctgc aggtggttgt gagctccttg ctgacagagg cagggtttga gagtgccgag      180

aaagcatccg tggaaacgct gacagagatg ctgcagagct acatttcaga aattgggaga      240

agtgccaagt cttactgtga gcacacagcc aggacccagc ccacactgtc cgatatcgtg      300

gtcacacttg ttgagatggg tttcaatgtg gacactctcc ctgcttatgc aaaacggtct      360

cagaggatgg tcatcactgc tcctccggtg accaatcagc cagtgacccc caaggccctc      420

actgcagggc agaaccgacc ccacccgccg cacatcccca gccattttcc tgagttccct      480

gatccccaca cctacatcaa aactccgacg taccgtgagc ccgtgtcaga ctaccaggtc      540

ctgcgggaga aggctgcatc ccagaggcgc gatgtggagc gggcacttac ccgtttcatg      600

gccaagacag gcgagactca gagtcttttc aaagatgacg tcagcacatt tccattgatt      660

gctgccagac ctttcaccat cccctacctg acagctcttc ttccgtctga actggagatg      720

caacaaatgg aagagacaga ttcctcggag caggatgaac agacagacac agagaacctt      780

gctcttcata tcagcatgga ggattctgga gccgagaagg agaacacctc tgtcctgcag      840

cagaacccct ccttgtcggg tagccggaat ggggaggaga acatcatcga taacccttat      900

ctgcggccgg tgaagaagcc caagatccgc aggaagaagt ccctctcctg agctgagaag      960

gaaacctggc ttgtacaggg gcgcagattc caccctcccg gggagttaaa gccactcaag     1020

ggaagaagag ggtgacctcc tcatggccaa gccgaggctg cagggtgtga tcggacatga     1080

ttttcatggc aaaccgtctt attaagatga cctattttca ctggatgttt gggttgagga     1140

agatatgaac agaataatga gaattttttt ttttattttg agatggagtc ttactctatc     1200

acccaggctg gaatgcagtg gtgtgatctc agctcactgc agtctcagca accctgggtc     1260

caagtgattc tcctgccttg gcctcccgag tagctgggac tagaggcaag cgccaccatg     1320

ctggctaatt tttgtatttt gagtagagat agggtttcgc catgttggcc aggctggtct     1380

tgaactcctg acctcaagtg atccacccgc attggcctcc caaagagttg cgattacagg     1440

tgtgagccac cacgcccagc taatttttgt atttttaata gagataaggt ttcgccatgt     1500

tggccaggct ggtcttgaac tcctgacctc aagtgataac ccgcctcggc ctcccaaagt     1560

gctgagatta caggcgtgag ccaccgcacc ccaccagaga ctttcttaat caatcaggct     1620

atgtggtggg gcatagcagc agccagtgac ttcgttcatt atcacaggat ttgattcctt     1680

tgaaactcaa gagaccaggg aaagtgacag gaaggaaagg gctctttgct gctgtgctta     1740

ttacaaggaa gactgtttgt ccagcgtgta tttcaggata tctggatccc ttttattgac     1800

tcacaatttg tggcaccact ttctcatccc agaacttcat tcttatttct ctcctcatct     1860

ggcctcccaa gtgctccgtt gagctgatga aaagttcttt gtactccctc aacgtgtcgg     1920

aaacaggagg ccacacagca cagctttgtt tggggtgggc aggagtcagg agtcttgagc     1980

agatgcatca ctgtgaagaa gaacgacatg tcggggctgc acctgtcctc ccgtcggcat     2040

ttgacgaaag ctccctgaag cggggcagca ctctcctcct gagagattta ccatttattg     2100

cccctgtgag gaatgtgtgc ttgggaactg ccaagtctta ccccttctgg aagaagaggt     2160

tttctctgac aagagcctag agcgtcggct ctattatgct gggacttgac agaggagcca     2220

tggggtttaa acagtaggaa agaggggcta cgcgcagtgg ctcacgcctg taatcccagc     2280

acttcgggag gcgaaggcag gtggatcact tgaggtcagg agttcgagac cagcctggcc     2340

aacatagtga aaccccgtct ctactaaaaa tacaaaaatt agccgggtgt ggttactcat     2400

gcctgtaatc ccagctactc gggaggctga ggcaggagaa tcacttgaac ctgggaggcg     2460

gaggttgcag tgagccgaga tcgtgccact gcactccagc ctgggtgaca gagcgagact     2520

ccatttcaaa aaaataaaaa aaggataaag taaacaatag gaaaggattt ggtggggtga     2580

gggtggggtg ttgagggctg ggcctcatct tgtattctga aagctgagaa acggctggtc     2640

agctggaagg ctggtggatg ggcaggagtg agccaagctg aggcgttctg caagaagcag     2700

gtctgagtct gtccaaccaa tttgtatcct gtggggagaa caacttcatt cttaacatac     2760

cctacaaacc agaaaacaag tttttaagga agatgctggg catgctgata gcttttctgg     2820

tctcctaagg aagagttttt aaaactaaat ccaaggaaga aaaatgtaac aacacgtgga     2880

agtgaacact ggatgaataa gcttgtttcc caaattagaa tcctaacgtc catatttagc     2940

ttcatgtatt cccctttggc ttccacagtt caactccttt tattttgaga cagggtctcg     3000

ctgtgtcgcc ccagctggag tatagtggca ctacctcggc tcactgcaac ctccactccc     3060

cgggttcaag caattctcag agtagctggg attacagatg cccgccacca catctggcta     3120

attttttttt ttttttttta gtagacacgg gattttgcta tgttgcccag gctggtcttg     3180

aactcctggc ctcaagtgat ccacccgcct tggccttcca aagtgttgag attacaggcg     3240

tgagccacgg tgcccagccc atctcttagt cttccattcc cttggtgaat ttggaaactt     3300

gaaaaacttg gggacttgac agcaggctcc atgttcttct ggcctcactg tactgtgtaa     3360

ggaaagagct gcttgtcagg aacggaagag gggacgctag taaaaaaaaa aaaattggat     3420

tccccaactg gactaaatag gagtttttca ggtttgtagt aacgtgaaac tctcctagat     3480

cgaagcagtt agactggcct atgtggcctt ctcagggttt gtgattcagt tcttagcgat     3540

tcttggcctg ataagtttat gaacacagcc ccacattcaa gccgtggcca atcccagctg     3600

ttctcactgc tcttgggagg tgttgtccca gtcagtgttt ctgcagcttc catttgttgt     3660

tgttatccag tgtaagcacc tgttgaatgc agatgtgctg agttagaggt gggatttgga     3720

aaagggctgc tatttctgct gttgagattt cagaggctat actctttttt tttcttttct     3780

tttttttttt tttttgagac ggcatctcac tcttatcgcc caggctggag tgcaatggcg     3840

tgatctcggc tcactgcaac ctccacctcc tgggttcaag ggattctcct gcctcagcct     3900

cctgagtagc tgggattaca ggcacctacc acaattctcg gctaattttt tttgtatttt     3960

tggtagagac ggggtttcac caggttggcc agggtggtct cgaacacctg acctcagatg     4020

atccacccac ctcggcctcc cagtgtgggt gggattacag gcatgagcca ccgcgcctgg     4080

cctcagaggc tatactctta taattttgtt ctgaggggag acagggaaag ggttagacaa     4140

cttgaaacat tgaccctgta taaaaatgca aaattctcaa tgtgtattta taaatttcta     4200

ttttttataa ctttatggga cttcttagag gccaaaagta gtaaacatgc agattaaaaa     4260

tgtttatgaa aatctcaata aaaattcata ataaaaactt tgtaaataaa tagaactgta     4320

agctttgaac ttaatttgtg ttcaaaagtt aacagcaatg tggacaaata agtcaggctt     4380

agcccttgtg ttggcctaag cacacctggg aacttagtaa aacttttatt ttggaaattt     4440

tcaaatacaa aattagagag caaaatatat gaacccctgt atatgcctca tcaagcttcc     4500

acacttgtca gtagcttgtt gattctgttt catctgtttc tcccactttt tgtcctttat     4560

tttctttcct cctggagtgt gtgtgtgtgt gtgtgtgcgt gtgtgtgcgt gtgagacaga     4620

gtttcgcgct ggagtgcaat ggtgcaatct tggcccactg caacttctgc ctcccgggtt     4680

caaatgattc tactgcctca gcttcctgag tagctgggat tataggtatc taccaccacc     4740

accacgcctg gctaattttt tctttttttt ttggagacgg agtctcgctc tgtcgcccag     4800

gctggattgc agtggattgt caagattgca gtggtgcaat ctcagctcac cgcaagctcc     4860

gccacccagg ttcacgccat tctcctgcct cagcctccca agtagctggg actacaggtg     4920

cctgctacca cgcccagcta attttttgta tttttcagta gagatggagt ttcactgcat     4980

tagccaggat ggtctcgatc tcctgacctc atgatccgcc cgcctcggcc tcccaaagtg     5040

ctgggattac aggcatgagc caccgcacct ggcctaattt ttttgtaggt ttagtagaga     5100

tggggtttca ccatgttggc cagactggtc tccaactcct gacctcaggt gatcacctgc     5160

ctcagcctcc taaagtgctg aggttacagg cgtgagcccc cgcgcctggc tcttctggag     5220

tatttttaaa tgcaaactcc agacctgtgt catttaatct aaatgtgtct atacgtatct     5280

ctgattgatc tttctttaaa ttttaatttt ggaataatta tagattcaca agatgttgca     5340

aaaaatgttg agagagatcc tatgtaccca tcacccactt tctcccagtg gtagcatctt     5400

gcataactgt ggtgcaatat caaaaccctt gcattcagtt tcagtgtaca atgtagatgg     5460

tatattagta caatgcatag agcttattta gttttcacca tgtgcacgtg tgtgttatgt     5520

gtgtgttgtt ccgtgcagtt tcatcgtgta gatttgtgta accaccagca cacaaatggt     5580

gaagacacag aaccattgca tcagtacagt tctccctcat gctgtctctt tgcaatcaca     5640

tccacctctc tgctcttcca cttctctcct ggcagccact actctgttct ctatctctaa     5700

tgttattgaa agaatgttat aaattgaatc ataaagtatg tgactttttt ctttttgaga     5760

cagagtcttg ctctatcgcc taggctggat ggagtgcagt ggagcgatcc cagctcactg     5820

caactcctcc acctcccggg ttcaagagat tctcctgcct cagcctccca agtagctggg     5880

attacaggca tgtgccacca cacccagcta acttttgtat ttttagtaga gatggggttt     5940

caccatgttg gccaggttgg tctccaactc ctgacctcaa gtgatccgcc cacctcagcc     6000

tcccaaagtg ctaggattat aggtatgacc caccgcacct ggccgagtat gggacttttt     6060

gacgttggct ttttcagttc tgcataattc tcttgaggtc catctaggtg gttgtgtgta     6120

tcagtagttc ctttcttttt attgctgagt agcatggagg caccatagtt taacacagtt     6180

tctttaacca ttcacgcatt gagacaaaaa aagttcttaa ttctgcgaac atcaacttcc     6240

tgtgcccagg tgcaagtgcg ggggcagctg gcccagggta gagctttacc atggaccctg     6300

gcgctcctgg aaaaaaattc aaggtatttt tcctcctctt ggagcgtgtg gcctacctca     6360

tctccatttg attactagct tttctttttc tcctttgtta aacagttatt taattttgaa     6420

gagataatat atgtatacag tataaaattt aaaagacaga aaaagatata agtgataaca     6480

aaatatcttc ctcctcccct gtttcccaga ggctcagacc tcatccctgg cagctgctat     6540

tatgttactg tcaatatgac cttatgtatt cttccagaag tattctgtgc atcaaatgca     6600

aatacttata ttttctactt ctcagtgtat tttttggtga tgttccatgt cagtaataaa     6660

gagcttctct gtttcgtggc                                                 6680


<210> 1822
<211> 3069
<212> DNA
<213> Homo sapiens

<400> 1822
caaggtttcg gggactgagt gggtttcaga ctttctctca ggatttccgc tggcttcagg       60

ttccggtcag gcgtcgggac agagcctgat ccaggcttcg gcggccggtg gcagctctcg      120

atcagctctc gcagtcggag aggcggctaa ggaaaggtgc cacagcagag acgcgaagga      180

gaggccctag aaccttttca aagaagaatg gaagaaacca tgaagcttgc tacgatggaa      240

gacacagtgg agtactgcct gttcctgata ccagatgagt caagggactc agataaacat      300

aaagagattc ttcagaagta cattgagaga ataatcactc ggtttgcacc tatgctggtc      360

ccctacatct ggcagaatca gcctttcaat cttaaatata aacctgggaa aggaggtgtt      420

cctgctcata tgtttggcgt gacaaagttt ggggataaca ttgaggatga atggtttatt      480

gtttatgtaa taaagcagat cacaaaggaa tttccagagt tagtagcaag gattgaagac      540

aatgatggtg aattcttgtt aatagaagct gctgactttc tccctaaatg gctggatcct      600

gaaaatagca ccaatagggt atttttctgc catggggaat tgtgtattat ccctgcacca      660

agaaaatctg gagcagaatc ttggttaccc accacacccc caacaattcc acaagcattg      720

aatataatca cagcacattc agaaaaaata cttgcttcag aatctatacg agctgctgtg      780

aataggcgca tcagagggta cccagaaaaa attcaggcct cacttcatcg agcacactgc      840

ttccttccag ctggcattgt ggcagtgcta aagcagcgcc ccagattggt ggctgcagca      900

gtccaggcat tttacctacg agaccctatt gacctgcgag cttgtcgtgt tttcaagaca      960

ttcttgcctg aaacacgaat aatgacatcg gtcacattca ctaaatgtct atatgcacaa     1020

ttggtgcaac aaaggtttgt gccagaccgg cggagtggat acaggctgcc tcctccatct     1080

gatccccagt accgagccca tgaattgggc atgaaattgg ctcatggatt tgagatctta     1140

tgctccaaat gtagcccaca tttttctgac tgcaagaaat cccttgtgac tgcctcacca     1200

ctctgggcca gtttccttga aagtctgaaa aagaatgatt actttaaggg actgatagaa     1260

ggttctgctc agtaccggga aaggctagaa atggcagaga attacttcca gctctcagta     1320

gactggccag aaagttctct tgctatgagc cctggtgaag aaatcttaac cttattacag     1380

acaataccat ttgatataga agaccttaag aaagaagcag ctaatcttcc cccagaggat     1440

gatgaccagt ggttagatct ctcaccagat cagctggacc agctgctgca ggaagctgtt     1500

ggcaaaaaag aatccgagtc tgtttccaag gaggagaagg agcagaacta tgacttaact     1560

gaagtctcag agagcatgaa agctttcata tccaaagtct caacccacaa gggagcagag     1620

ctgcctcgag aaccttctga ggctccaatc acttttgatg cagattcttt tcttaattat     1680

tttgataaga ttttagggcc aaggcctaat gagtcagatt ctgatgatct ggatgatgaa     1740

gactttgaat gtttagatag tgatgatgac ttggactttg aaacacacga acctggcgaa     1800

gaggcttccc tgaaaggaac acttgataat ctcaagtcat acatggccca gatggaccag     1860

gaactagcac acacctgcat cagcaaaagt ttcaccacta ggaaccaagt ggaacctgta     1920

tcccagacta ccgataacaa ttcagatgag gaagattctg gtacgggaga atctgttatg     1980

gcaccagtag atgtagacct gaacctggtt tcaaatatat tggaatccta tagctcccaa     2040

gctggactgg caggacctgc ttccaatctt ttacaaagca tgggagtgca gctgcctgac     2100

aacaccgatc acagaccaac aagtaagcca acaaaaaatt aaccagcaca tttagcttct     2160

cttttttctt tttaaataaa tattgaatat gattctgttc atttctagtt tagattactc     2220

atttagtaaa aatgtttctt cattacaagt tttacagatt gacttctcca tgagccccaa     2280

atgtggccct cttggcacaa gtctttgtga tctcagctgt gggttataca caggttttga     2340

actcggcagg gtagaatcta gcccctagac aaccttgaga tgaaattcac acacttcatg     2400

ctaaagacat accctaccac aatataccct tggagtaatt ctaaatattt aaatttctcc     2460

cttactgcta ttcatcctca gatcaaaatt tcaagttgac aaatttggat ttgaaaactc     2520

attcactttt tcaatttttt taatgaggca taacatgcat atggttaagt gcacaaatct     2580

taagtgtaca gtcagtgaat ttttgcatgt atgtatgtac ctgaagcaag atatagaact     2640

tatttacttg taaataacag ctatattgat atgtcacata ccaaaaaatt taccctttaa     2700

attatacaat tcagtggttt ttagtatatt tacaaaattg tgcaaccatc cctaccatct     2760

aattctagaa tattagaaac cccatactca ctaatagtct ctcattccct tctactccca     2820

gcccctagaa accactagtc tactttctgt ctctatggat ttgcctattt tggatatttc     2880

atacctgata ctgtacttaa ttgttttaat taattaattg gtttgatatt taatataact     2940

gatatatctt ttgctaagat gaaatgttta tttcttaaaa tgatgctcat attcctccta     3000

aaataaatca agtattatct atatatcata aaattcacca ttaaaagcaa aaaaaaagtc     3060

ttctttaca                                                             3069


<210> 1823
<211> 2445
<212> DNA
<213> Homo sapiens

<400> 1823
gaagaggcag aaaaacaaga gataacaaag gctccgtttc ctttctgtga gagaaggctt       60

ttgtctttcc tcctgctacg atgtcagtgt ctggcaagaa agagtttgat gtgaaacaga      120

tcctaaggct acgctggagg tggtttagtc atccttttca aggttccacc aacactggaa      180

gctgtcttca gcaggaagga tatgagcata gagggacccc ggttcagggc aggttgaaga      240

gccactctcg ggacagaaac ggactgaaga aaagcaacag tcctgtccac cacaatatac      300

tggcaccagt gccaggaccg gcccctgccc atcagagagc cgttcagaat ttgcagcaac      360

ataatctgat agtacatttt caagcaaatg aagatactcc taaatcagtt ccagagaaga      420

atttattcaa agaagcttgt gagaaacgcg cacaagattt ggagatgatg gctgatgaca      480

atatagaaga ttctacagca agattagata cacaacactc tgaagacatg aatgccacca      540

gatctgaaga gcagttccat gttataaacc acgcagagca aactcttcgt aaaatggaga      600

actacttgaa agagaaacaa ctatgtgatg tgctactgat tgcaggacac ctccgcatcc      660

cagcccatag gttggttctc agcgcagtgt ctgattattt tgctgcaatg tttactaatg      720

atgtgcttga agccaaacaa gaagaggtca ggatggaagg agtagatcca aatgcactaa      780

attccttggt gcagtatgct tacacaggag tcctgcaatt gaaagaagat accattgaaa      840

gtttgctggc tgcagcttgt cttctgcagc tgactcaggt cattgatgtt tgctccaatt      900

ttctcataaa gcagctccat ccttcaaact gcttagggat tcgatcattt ggagatgccc      960

aaggctgtac agaacttctg aacgtggcac acaaatacac tatggaacac ttcattgagg     1020

taataaaaaa ccaagaattc ctcctgcttc cagctaatga aatttcaaaa cttctgtgca     1080

gtgatgacat taatgtgcct gatgaagaga ccatttttca tgctctaatg cagtgggtgg     1140

ggcatgatgt gcagaatagg caaggagaac tggggatgct gctttcttac atcagactgc     1200

cattactccc accacagtta ctggcagatc ttgaaaccag ttccatgttt actggtgatc     1260

ttgagtgtca gaagctcctg atggaagcta tgaagtatca tcttttgcct gagagaagat     1320

ccatgatgca aagccctcgg acaaagccta gaaaatcaac tgtgggggca ctttatgctg     1380

taggaggcat ggatgctatg aaaggtacta ctactattga aaaatatgac ctcaggacca     1440

acagttggct acatattggc accatgaatg gccgtaggct tcaatttgga gtcgcagtta     1500

ttgataataa gctctatgtc gtgggaggaa gagacggttt aaaaactttg aatacagtgg     1560

aatgttttaa tccagttggc aaaatctgga ctgtgatgcc tcccatgtca acacatcggc     1620

acggcttagg tgtagccact cttgaaggac caatgtatgc tgtaggtggt catgatggat     1680

ggagctatct aaatactgta gaaagatggg accctgaggg acgacagtgg aattacgtag     1740

ccagtatgtc aactcctaga agcacagttg gtgttgttgc attaaacaac aaattatatg     1800

ctattggtgg acgtgatgga agttcctgcc tcaaatcaat ggaatacttt gacccacaca     1860

ctaacaagtg gagtttgtgt gctccaatgt ccaaaagacg tggaggtgtg ggagttgcca     1920

catacaatgg attcttatat gttgtagggg ggcatgatgc ccctgcttcc aaccattgct     1980

ccaggctttc tgactgtgtg gaacggtatg atccaaaagg tgattcatgg tcaactgtgg     2040

cacctctgag tgttcctcga gatgctgttg ctgtgtgccc tcttggagac aaactctacg     2100

tggttggagg atatgacgga catacttatt tgaacacagt tgagtcatat gatgcacaga     2160

gaaatgaatg gaaagagagc atgcaagaac ttctacaaaa cttctatacc acacagaagc     2220

tgaaagagac tctggggcac taaattcaga tcctttctcc acacagcaat gacatttatc     2280

aatctgactc aggtgtggct gttgcccctt tttgatatgg agggaacact gaaagacagt     2340

ttccttctgg agttccaaat gcaatataga aaaaaaaacc ctgtgactct ggattttatt     2400

ttaagttctc taacaagact cctaccttga gatcttagtc taggt                     2445


<210> 1824
<211> 5818
<212> DNA
<213> Homo sapiens

<400> 1824
agtgggggag gggagagaaa gcaagaaaga ctgctctcgg cacttgtgct tttgttagtt       60

ctacagaaga ggcagaaaaa caagagataa caaaggctcc gtttcctttc tgtgagagaa      120

ggcttttgtc tttcctcctg ctacgatgtc agtgtctggc aagaaagagt ttgatgtgaa      180

acagatccta aggctacgct ggaggtggtt tagtcatcct tttcaaggtt ccaccaacac      240

tggaagctgt cttcagcagg aaggatatga gcatagaggg accccggttc agggcaggtt      300

gaagagccac tctcgggaca gaaacggact gaagaaaagc aacagtcctg tccaccacaa      360

tatactggca ccagtgccag gaccggcccc tgcccatcag agagccgttc agaatttgca      420

gcaacataat ctgatagtac attttcaagc aaatgaagat actcctaaat cagttccaga      480

gaagaattta ttcaaagaag cttgtgagaa acgcgcacaa gatttggaga tgatggctga      540

tgacaatata gaagattcta cagcaagatt agatacacaa cactctgaag acatgaatgc      600

caccagatct gaagagcagt tccatgttat aaaccacgca gagcaaactc ttcgtaaaat      660

ggagaactac ttgaaagaga aacaactatg tgatgtgcta ctgattgcag gacacctccg      720

catcccagcc cataggttgg ttctcagcgc agtgtctgat tattttgctg caatgtttac      780

taatgatgtg cttgaagcca aacaagaaga ggtcaggatg gaaggagtag atccaaatgc      840

actaaattcc ttggtgcagt atgcttacac aggagtcctg caattgaaag aagataccat      900

tgaaagtttg ctggctgcag cttgtcttct gcagctgact caggtcattg atgtttgctc      960

caattttctc ataaagcagc tccatccttc aaactgctta gggattcgat catttggaga     1020

tgcccaaggc tgtacagaac ttctgaacgt ggcacacaaa tacactatgg aacacttcat     1080

tgaggtaata aaaaaccaag aattcctcct gcttccagct aatgaaattt caaaacttct     1140

gtgcagtgat gacattaatg tgcctgatga agagaccatt tttcatgctc taatgcagtg     1200

ggtggggcat gatgtgcaga ataggcaagg agaactgggg atgctgcttt cttacatcag     1260

actgccatta ctcccaccac agttactggc agatcttgaa accagttcca tgtttactgg     1320

tgatcttgag tgtcagaagc tcctgatgga agctatgaag tatcatcttt tgcctgagag     1380

aagatccatg atgcaaagcc ctcggacaaa gcctagaaaa tcaactgtgg gggcacttta     1440

tgctgtagga ggcatggatg ctatgaaagg tactactact attgaaaaat atgacctcag     1500

gaccaacagt tggctacata ttggcaccat gaatggccgt aggcttcaat ttggagtcgc     1560

agttattgat aataagctct atgtcgtggg aggaagagac ggtttaaaaa ctttgaatac     1620

agtggaatgt tttaatccag ttggcaaaat ctggactgtg atgcctccca tgtcaacaca     1680

tcggcacggc ttaggtgtag ccactcttga aggaccaatg tatgctgtag gtggtcatga     1740

tggatggagc tatctaaata ctgtagaaag atgggaccct gagggacgac agtggaatta     1800

cgtagccagt atgtcaactc ctagaagcac agttggtgtt gttgcattaa acaacaaatt     1860

atatgctatt ggtggacgtg atggaagttc ctgcctcaaa tcaatggaat actttgaccc     1920

acacactaac aagtggagtt tgtgtgctcc aatgtccaaa agacgtggag gtgtgggagt     1980

tgccacatac aatggattct tatatgttgt aggggggcat gatgcccctg cttccaacca     2040

ttgctccagg ctttctgact gtgtggaacg gtatgatcca aaaggtgatt catggtcaac     2100

tgtggcacct ctgagtgttc ctcgagatgc tgttgctgtg tgccctcttg gagacaaact     2160

ctacgtggtt ggaggatatg acggacatac ttatttgaac acagttgagt catatgatgc     2220

acagagaaat gaatggaaag aggaagttcc tgttaacatt ggaagagctg gtgcatgtgt     2280

tgtagtggtg aagctaccct aaagctatct atctttatca aatggaatga aactagataa     2340

tttcaagaaa ctgagtagga caaagggaga aagaaataca tgttcttttt cctgcaatta     2400

ataatcagac tggaaaattg ttgtatcatt ttaatttgta gttacaattg ctttcattcg     2460

tgaagccgaa acgtttttaa acatgaatta catatgaatt attaagcata tgtgctttcg     2520

cagctgataa tataaaagga aatcccacag tctagatata gccccattac tacaaaatgc     2580

taaaatattt aatgaaaatt gatggtggcc acagtgtgca ggttataaaa gcattaatac     2640

atttcaaggt aagagcctta aaagttaaaa acattttcag ttttttttta aaaaacgtac     2700

tcttattatc tggaacatag aaatataaaa ggtaacatct aaagcttaga atagtgtgat     2760

ttttagtaag ccattattct cctattcaaa taatatccca aagagctaaa caattcctta     2820

catttaccaa gaggaaagct tttactgtgt tgaagctaaa aaaataatgg ctctttgaca     2880

aaacttgtta tgttgatcgc ggtatgtcaa aatttttaca ggtttgctca tctgccagag     2940

cacacatata aatttggtat ttcttaacat attatcttgt tagatttgtt accagtaaaa     3000

tattactgta atttcatata cacagtctat acaatgaaat aatgaatatt tatcatattg     3060

atacaaactg tgacctcagc ttcagagtgt cagggcctca cttgtataga atgtaatgtt     3120

ctcctcaaac atttatgtta actctataaa caaatatcgt taagttaaac aagttttcaa     3180

aaacaaaaca atttttaaag taccttaaaa ttgaggatgt tactcagtgt taacacatgg     3240

gaacaccaaa atattcaata agcctggtca attctatagt tatctttttt gtaccaacac     3300

atgcttttct gttactgtta tattatccag tagaaaatgt taggatatgt gtgctatata     3360

aaaaaaaaaa aagacttgtt aagttttaaa ataacaaaaa tggctagttg aatagtattt     3420

tatgtgtaat tcttccattt attctgttta attatacaac taagatgaaa tattgaaaaa     3480

ccctttgtga aagtaacttt tcaagtaaat gcacaacttt agaatttcta caaataagtt     3540

cttttaaaca gtctttttat tgtggattgt gaaatcaaaa tctggagaaa tgcttataaa     3600

atatactact agcttttaag ttttaagaaa gaagaacgta agttgtacaa agatatttgt     3660

actttgacaa actgaattta aataaacttt atttcctctc actatagtgt ggctttagaa     3720

tatatcaagt acaacctgaa tggacttttt gattttacat ttcctatatc actaaaatac     3780

ttaaacacaa aaataaaatt ccactccttt atttcttctt acacctgcca ttgtctctaa     3840

ttctaaagag agagctatag atttctgcag ttctagaggt gaagatagag acatagagag     3900

gctgtgaaac acacatacag ccctgttagg tcttttgaat tcacacctta ttgaaatcag     3960

tgtagaagta gagttaccta aacctttatc gccaatgcac agcttggcct gttaagttaa     4020

atgtgggtgt caaccagtgg aaaagatcaa aggacctttt gcagcctagc ttgccaatct     4080

tccagtaaca acgaggtgct accaataggc agactgtgtc tagagtcatg catggacaag     4140

aggaaagtga aagttgaata ctctcttctc aatggcatag ctggacttga ttaagtattg     4200

actcatagaa gagacatgta tgtttcccgg ggctacccct tcatagctgc atttaaaaat     4260

ggtgttcagg ccactatggc tgctgtggtt tgaatatttt tttccctcga aaactcatgt     4320

tgaaacttaa ctcctaatgt agcagtactg agaggcaggg cccttaagag gtgattgggc     4380

catgaggtct gtgccctcct gaatggatta atccattcat ggattaatgg attattatga     4440

gtgggggact ggtgacttta tatgaaaagg aaggaagagt gacctaagct agcatgctca     4500

gggtgcaccg tatgtcccct ggtcatgtga tgctatgtgt taccttggga cttacctgac     4560

agctcttacc aacaagaagg ccatcccaga tatggcctct caacctcaga cttctcagcc     4620

tgcctaactg taagaaatta attctttttc tttataaatt acccaggttc tgttttaagc     4680

ctcagaaaat gaactaagac aatgccctag atgagctgcc aaaatctgag cagatatgag     4740

ccatcagaat agagacctgc agaggcccag ggcactcaaa cataactgtg cttgtctcag     4800

tcaaacttaa ttgggaaaag gaggagtaag agcaggccct ttctgacatg ctttagcaga     4860

gataacttat cagggctagt ttaaacaaat gtgtatagga aaggatgtta tttatatatt     4920

cttacaagag tgtaagggct cacacattta ctgtactcag atctgaaaga caatgttgct     4980

tcttgatttt tttctataat cactatgacc gtgttcacga ttccctactc tgcaactctc     5040

agcatgcatc atgatgattc tctaacactg tctgtcacct tcctgtattt ccacagagca     5100

tgcaagaact tctacaaaac ttctatacca cacagaagct gaaagagact ctggggcact     5160

aaattcagat cctttctcca cacagcaatg acatttatca atctgactca ggtgtggctg     5220

ttgccccttt ttgatatgga gggaacactg aaagacagtt tccttctgga gttccaaatg     5280

caatatagaa aaaaaaaccc tgtgactctg gattttattt taagttctct aacaagactc     5340

ctaccttgag atcttagtct aggtaaagaa aaaaaaaaaa aggtcatgaa acacaaatgt     5400

cctcaactgt catcattcta tgtttacttt ctcccaatca catcacctga ggtagaagag     5460

atttttcagt tgctatttct cttcgtaatg aattttcttt acatcctgtc cacactgctg     5520

gagatactaa gtcccaacct aaatgatgga aggagcatct cccctcttgt ctgtggaaga     5580

tatcacatga actacctaat tttcaagcat ggatctccat atttcaaagg aaagttttaa     5640

aaatgttttt aaaacttcaa atatctcacc acagtgaatt atgggtaagg tgataatatg     5700

tttaattagc ttgatttaat catcccacac tgtatacata tgccaaaata tcattttgta     5760

tgccataata tatatgattt atgaattata gtaatattaa taaaagtgtt aaagcttt       5818


<210> 1825
<211> 1797
<212> DNA
<213> Homo sapiens

<400> 1825
atgtatgatg atgccactgc actccagcct gggggtcagc cagattctgt cttaaaaaca       60

acaacaacaa caacaacaaa acctgctgaa tgaatggacc tgtcagcccc aaatccaagg      120

ccaggccatc ctctccctcc acatcctggc acaggcctgc ctccccctgc cccagcccag      180

ggccaggcca cactctgcct ccaaagccac cgtccccccg aggcaccact gcatccccca      240

aggggcgggt tcggaggaag gaggaggcaa aggagagccc cagcgccgca gggcccgagg      300

acaagagcca gagcaagcgc agggccagta acgagaagga gtcagcagcc ccagcctcac      360

cggcaccttc gccggcgccc tcgcccaccc cagccccgcc ccagaaggag cagccccccg      420

cggagacccc tacagcccct gctcccccgg tgacccctag caaaccaatg gccggcacca      480

cagaccgaga agaagccact cggctcttgg ctgagaagcg gcgccaggcc cgggagcagc      540

gggagcgcga ggagcaggag cggaggctgc aggcagaaag ggacaagcga atgcgagagg      600

agcagctggc acgggaggcc gaggcccggg cggagcggga ggcggaggcc cggaggcggg      660

aggagcagga ggcacgagag aaggcgcagg ccgagcagga ggagcaggag cggctgcaga      720

agcagaaaga ggaggccgaa gctcggtcgc gggaagaggc ggagcggcag cgtctggagc      780

gggaaaagca cttccagcag caggagcaag agcggcaaga gcgcagaaag cgtctggagg      840

agatcatgaa gaggactcgg aagtcagaag tttctgaaac caagaagcag gacagcaagg      900

aggccaacgc caacggttcc agcccagagc ctgtgaaagc tgtggaggct cggtccccag      960

ggctgcagaa ggaggctgtg cagaaagagg agcccatccc acaggagcct cagtggagtc     1020

tcccaagcaa ggagttgcca gcgtccctgg tgaatggcct gcagcctctc ccagcacacc     1080

aggagaatgg cttctccacc aacggaccct ctggggacaa gagtctgagc cgaacaccag     1140

agacactcct gccctttgca gaggcagaag ccttcctcaa gaaagctgtg gtgcagtccc     1200

cgcaggtcac agaagtcctt taagagggtt tgccttggat ccgggcacag ttgtgagggc     1260

tcctctgcat cacctaccag gatgtctgga ggagaaaaag acagaacaaa gatggaagtg     1320

gcctgggccc ctgggggtgg gtcctctctg ttgtttttaa tctgcacctt atagactgat     1380

gtctctttgg ccggagccag atctgcccct cagtgcattc gtgtgctcgc acgcgcagac     1440

atcccttctc ccccatacac acatatacac tcacagcctc tctggcctct tcccttgggg     1500

aggggccacc tgtagtattt gccttgattt ggtggggtac agtggatgtg aatactgtaa     1560

atagcttgtg ctcagactcc tctgcgtgga gagggtgggt gcaggaggca gaccctcccc     1620

ccaaagcccc ctggggagat cttcctctct ctatttaact gtaactgagg gggatcccag     1680

gtctggggat gggggacacc ttgggccaca ggatactggt tgcttcaggg gtacccatgc     1740

cccctgccct cgcctggaat cagtgttact gcatctgatt aaatgtctcc agaaata        1797


<210> 1826
<211> 3238
<212> DNA
<213> Homo sapiens

<400> 1826
gaacgggttc gcgaccgcag ccgagagacc ccgggcgacc ggcacctccg agactcgcgg       60

gccacctgcc tcgaccttcc ccggagcgcc cccgcctccg agtcgctact tgccgggccg      120

ggccgggccg ggcgtgatgc gccgcgggac ccctgtcctg gccactggcc gccgccgccg      180

ccgccgctga gaccccgaga cccccagtga cgccgcagcc atggagagcg gcccgcgtgc      240

ggagctgggg gcgggcgcac ccccagctgt ggtcgccagg acccccccag agccaagacc      300

ttctccagaa ggtgaccctt cccccccacc accaccaatg tcagccctgg tccccgacac      360

tcccccggac acccctcctg ccatgaagaa tgccactagc tctaagcagc tcccactgga      420

accagagagc ccctcagggc aggtcgggcc taggccagcc cccccgcagg aagagtcccc      480

ttcctctgaa gcaaagagca gaggacccac cccaccagcc atgggcccac gggatgccag      540

acctcctcga aggagcagcc agccatctcc aacagcagtg ccagcctccg acagccctcc      600

caccaagcaa gaggtgaaga aggcaggaga gagacacaag ctggcaaagg agcggcgaga      660

agagcgggcc aagtacctgg cggccaagaa ggcagtgtgg ctggagaagg aggagaaggc      720

caaggcgctg cgggagaagc agctccagga gcgccggcgc cggctggagg agcaacgtct      780

taaagccgag caacgccgtg cagccctgga ggaacggcag cggcagaagc tcgagaaaaa      840

caaggagcgc tatgaagcag ccatccaacg gtcagtgaag aagacgtggg ccgaaatccg      900

gcagcagcgc tggtcctggg caggggccct gcaccacagc tctccaggac ataagaccag      960

tgggagcagg tgctccgtgt cggcagttaa cctgcccaaa cacgtggact ctataatcaa     1020

caagcggctc tcaaagtcct ctgccacgct ctggaactcc cccagtagaa atcgcagcct     1080

gcagctgagc gcatgggaga gcagcatcgt ggatcgtctg atgacgccca ctctctcctt     1140

ccttgctcgg agtcgcagcg cggtcacact gccccgcaac ggccgggacc aggccgtgcc     1200

ggtgtgcccg cgctcggcct ccgccagccc cctgacgccg tgcagcgtca cccgaagcgt     1260

gcaccgctgc gcccccgccg gtgagcgcgg ggagcgccgc aagcccaacg ccgggggcag     1320

ccccgctccg gtgcgccgcc ggccggaggc ctcgccggtg cagaaaaagg agaagaagga     1380

caaggagcgg gaaaacgaga aggagaagag tgccctagcc cgggagcgca gcctcaagaa     1440

gcgccagtcg ctgcccgcct ccccacgtgc ccgcctctct gccagcaccg cctctgagct     1500

cagccccaaa tccaaggcca ggccatcctc tccctccaca tcctggcaca ggcctgcctc     1560

cccctgcccc agcccagggc caggccacac tctgcctcca aagccaccgt ccccccgagg     1620

caccactgca tcccccaagg ggcgggttcg gaggaaggag gaggcaaagg agagccccag     1680

cgccgcaggg cccgaggaca agagccagag caagcgcagg gccagtaacg agaaggagtc     1740

agcagcccca gcctcaccgg caccttcgcc ggcgccctcg cccaccccag ccccgcccca     1800

gaaggagcag ccccccgcgg agacccctac agacgctgct gtcttgacct cacccccagc     1860

ccctgctccc ccggtgaccc ctagcaaacc aatggccggc accacagacc gagaagaagc     1920

cactcggctc ttggctgaga agcggcgcca ggcccgggag cagcgggagc gcgaggagca     1980

ggagcggagg ctgcaggcag aaagggacaa gcgaatgcga gaggagcagc tggcacggga     2040

ggccgaggcc cgggcggagc gggaggcgga ggcccggagg cgggaggagc aggaggcacg     2100

agagaaggcg caggccgagc aggaggagca ggagcggctg cagaagcaga aagaggaggc     2160

cgaagctcgg tcgcgggaag aggcggagcg gcagcgtctg gagcgggaaa agcacttcca     2220

gcagcaggag caagagcggc aagagcgcag aaagcgtctg gaggagatca tgaagaggac     2280

tcggaagtca gaagtttctg aaaccaagaa gcaggacagc aaggaggcca acgccaacgg     2340

ttccagccca gagcctgtga aagctgtgga ggctcggtcc ccagggctgc agaaggaggc     2400

tgtgcagaaa gaggagccca tcccacagga gcctcagtgg agtctcccaa gcaaggagtt     2460

gccagcgtcc ctggtgaatg gcctgcagcc tctcccagca caccaggaga atggcttctc     2520

caccaacgga ccctctgggg acaagagtct gagccgaaca ccagagacac tcctgccctt     2580

tgcagaggca gaagccttcc tcaagaaagc tgtggtgcag tccccgcagg tcacagaagt     2640

cctttaagag ggtttgcctt ggatccgggc acagttgtga gggctcctct gcatcaccta     2700

ccaggatgtc tggaggagaa aaagacagaa caaagatgga agtggcctgg gcccctgggg     2760

gtgggtcctc tctgttgttt ttaatctgca ccttatagac tgatgtctct ttggccggag     2820

ccagatctgc ccctcagtgc attcgtgtgc tcgcacgcgc agacatccct tctcccccat     2880

acacacatat acactcacag cctctctggc ctcttccctt ggggaggggc cacctgtagt     2940

atttgccttg atttggtggg gtacagtgga tgtgaatact gtaaatagct tgtgctcaga     3000

ctcctctgcg tggagagggt gggtgcagga ggcagaccct ccccccaaag ccccctgggg     3060

agatcttcct ctctctattt aactgtaact gagggggatc ccaggtctgg ggatggggga     3120

caccttgggc cacaggatac tggttgcttc aggggtaccc atgccccctg ccctcgcctg     3180

gaatcagtgt tactgcatct gattaaatgt ctccagaaat aaagaataat tctgccaa       3238


<210> 1827
<211> 3324
<212> DNA
<213> Homo sapiens

<400> 1827
gggttcgcga ccgcagccga gagaccccgg gcgaccggca cctccgagac tcgcgggcca       60

cctgcctcga ccttccccgg agcgcccccg cctccgagtc gctacttgcc gggccgggcc      120

gggccgggcg tgatgcgccg cgggacccct gtcctggcca ctggccgccg ccgccgccgc      180

cgctgagacc ccgagacccc cagtgacgcc gcagccatgg agagcggccc gcgtgcggag      240

ctgggggcgg gcgcaccccc agctgtggtc gccaggaccc ccccagagcc aagaccttct      300

ccagaaggtg acccttcccc cccaccacca ccaatgtcag ccctggtccc cgacactccc      360

ccggacaccc ctcctgccat gaagaatgcc actagctcta agcagctccc actggaacca      420

gagagcccct cagggcaggt cgggcctagg ccagcccccc cgcaggaaga gtccccttcc      480

tctgaagcaa agagcagagg acccacccca ccagccatgg gcccacggga tgccagacct      540

cctcgaagga gcagccagcc atctccaaca gcagtgccag cctccgacag ccctcccacc      600

aagcaagagg tgaagaaggc aggagagaga cacaagctgg caaaggagcg gcgagaagag      660

cgggccaagt acctggcggc caagaaggca gtgtggctgg agaaggagga gaaggccaag      720

gcgctgcggg agaagcagct ccaggagcgc cggcgccggc tggaggagca acgtcttaaa      780

gccgagcaac gccgtgcagc cctggaggaa cggcagcggc agaagctcga gaaaaacaag      840

gagcgctatg aagcagccat ccaacggtca gtgaagaaga cgtgggccga aatccggcag      900

cagcgctggt cctgggcagg ggccctgcac cacagctctc caggacataa gaccagtggg      960

agcaggtgct ccgtgtcggc agttaacctg cccaaacacg tggactctat aatcaacaag     1020

cggctctcaa agtcctctgc cacgctctgg aactccccca gtagaaatcg cagcctgcag     1080

ctgagcgcat gggagagcag catcgtggat cgtctgatga cgcccactct ctccttcctt     1140

gctcggagtc gcagcgcggt cacactgccc cgcaacggcc gggaccaggg taggggctgc     1200

gaccctggga gaggccccac gtggggccgg gcaggggcca gcctggcgcg cgggccgcaa     1260

cccgaccgca ctcatccctc tgcagccgtg ccggtgtgcc cgcgctcggc ctccgccagc     1320

cccctgacgc cgtgcagcgt cacccgaagc gtgcaccgct gcgcccccgc cggtgagcgc     1380

ggggagcgcc gcaagcccaa cgccgggggc agccccgctc cggtgcgccg ccggccggag     1440

gcctcgccgg tgcagaaaaa ggagaagaag gacaaggagc gggaaaacga gaaggagaag     1500

agtgccctag cccgggagcg cagcctcaag aagcgccagt cgctgcccgc ctccccacgt     1560

gcccgcctct ctgccagcac cgcctctgag ctcagcccca aatccaaggc caggccatcc     1620

tctccctcca catcctggca caggcctgcc tccccctgcc ccagcccagg gccaggccac     1680

actctgcctc caaagccacc gtccccccga ggcaccactg catcccccaa ggggcgggtt     1740

cggaggaagg aggaggcaaa ggagagcccc agcgccgcag ggcccgagga caagagccag     1800

agcaagcgca gggccagtaa cgagaaggag tcagcagccc cagcctcacc ggcaccttcg     1860

ccggcgccct cgcccacccc agccccgccc cagaaggagc agccccccgc ggagacccct     1920

acagacgctg ctgtcttgac ctcaccccca gcccctgctc ccccggtgac ccctagcaaa     1980

ccaatggccg gcaccacaga ccgagaagaa gccactcggc tcttggctga gaagcggcgc     2040

caggcccggg agcagcggga gcgcgaggag caggagcgga ggctgcaggc agaaagggac     2100

aagcgaatgc gagaggagca gctggcacgg gaggccgagg cccgggcgga gcgggaggcg     2160

gaggcccgga ggcgggagga gcaggaggca cgagagaagg cgcaggccga gcaggaggag     2220

caggagcggc tgcagaagca gaaagaggag gccgaagctc ggtcgcggga agaggcggag     2280

cggcagcgtc tggagcggga aaagcacttc cagcagcagg agcaagagcg gcaagagcgc     2340

agaaagcgtc tggaggagat catgaagagg actcggaagt cagaagtttc tgaaaccaag     2400

cagaagcagg acagcaagga ggccaacgcc aacggttcca gcccagagcc tgtgaaagct     2460

gtggaggctc ggtccccagg gctgcagaag gaggctgtgc agaaagagga gcccatccca     2520

caggagcctc agtggagtct cccaagcaag gagttgccag cgtccctggt gaatggcctg     2580

cagcctctcc cagcacacca ggagaatggc ttctccacca acggaccctc tggggacaag     2640

agtctgagcc gaacaccaga gacactcctg ccctttgcag aggcagaagc cttcctcaag     2700

aaagctgtgg tgcagtcccc gcaggtcaca gaagtccttt aagagggttt gccttggatc     2760

cgggcacagt tgtgagggct cctctgcatc acctaccagg atgtctggag gagaaaaaga     2820

cagaacaaag atggaagtgg cctgggcccc tgggggtggg tcctctctgt tgtttttaat     2880

ctgcacctta tagactgatg tctctttggc cggagccaga tctgcccctc agtgcattcg     2940

tgtgctcgca cgcgcagaca tcccttctcc cccatacaca catatacact cacagcctct     3000

ctggcctctt cccttgggga ggggccacct gtagtatttg ccttgatttg gtggggtaca     3060

gtggatgtga atactgtaaa tagcttgtgc tcagactcct ctgcgtggag agggtgggtg     3120

caggaggcag accctccccc caaagccccc tggggagatc ttcctctctc tatttaactg     3180

taactgaggg ggatcccagg tctggggatg ggggacacct tgggccacag gatactggtt     3240

gcttcagggg tacccatgcc ccctgccctc gcctggaatc agtgttactg catctgatta     3300

aatgtctcca gaaataaaga ataa                                            3324


<210> 1828
<211> 1084
<212> DNA
<213> Homo sapiens

<400> 1828
aacctgccca aacacgtgga ctctataatc aacaagcggc agcgtctgga gcgggaaaag       60

cacttccagc agcaggagca agagcggcaa gagcgcagaa agcgtctgga ggagatcatg      120

aagaggactc ggaagtcaga agtttctgaa accaagaagc aggacagcaa ggaggccaac      180

gccaacggtt ccagcccaga gcctgtgaaa gctgtggagg ctcggtcccc agggctgcag      240

aaggaggctg tgcagaaaga ggagcccatc ccacaggagc ctcagtggag tctcccaagc      300

aaggagttgc cagcgtccct ggtgaatggc ctgcagcctc tcccagcaca ccaggagaat      360

ggcttctcca ccaacggacc ctctggggac aagagtctga gccgaacacc agagacactc      420

ctgccctttg cagaggcaga agccttcctc aagaaagctg tggtgcagtc cccgcaggtc      480

acagaagtcc tttaagaggg tttgccttgg atccgggcac agttgtgagg gctcctctgc      540

atcacctacc aggatgtctg gaggagaaaa agacagaaca aagatggaag tggcctgggc      600

ccctgggggt gggtcctctc tgttgttttt aatctgcacc ttatagactg atgtctcttt      660

ggccggagcc agatctgccc ctcagtgcat tcgtgtgctc gcacgcgcag acatcccttc      720

tcccccatac acacatatac actcacagcc tctctggcct cttcccttgg ggaggggcca      780

cctgtagtat ttgccttgat ttggtggggt acagtggatg tgaatactgt aaatagcttg      840

tgctcagact cctctgcgtg gagagggtgg gtgcaggagg cagaccctcc ccccaaagcc      900

ccctggggag atcttcctct ctctatttaa ctgtaactga gggggatccc aggtctgggg      960

atgggggaca ccttgggcca caggatactg gttgcttcag gggtacccat gccccctgcc     1020

ctcgcctgga atcagtgtta ctgcatctga ttaaatgtct ccagaaataa agaataattc     1080

tgcc                                                                  1084


<210> 1829
<211> 1923
<212> DNA
<213> Homo sapiens

<400> 1829
cgagattccc tattaaaaaa aaatagaatt gatgcaaaca gcctgttcct tccggggttt       60

tgggctggaa ctgcagcgct tagagagctc ggtggaagct gctaaaggcg gaggcggggc      120

tctggcgagt tctccttcca ccttccccca cccttctctg ccaaccgctg tttcagcccc      180

tagctggatt ccagccattg ctgcagctgc tccacagccc ttttcaggac ccaaacaacc      240

gcagccgctg ttcccaggat ggtgatccgt gtatatattg catcttcctc tggctctaca      300

gcgattaaga agaaacaaca agatgtgctt ggtttcctag aagccaacaa aataggattt      360

gaagaaaaag atattgcagc caatgaagag aatcggaagt ggatgagaga aaatgtacct      420

gaaaatagtc gaccagccac aggttacccc ctgccacctc agattttcaa tgaaagccag      480

tatcgcgggg actatgatgc cttctttgaa gccagagaaa ataatgcagt gtatgccttc      540

ttaggcttga cagccccacc tggttcaaag gaagcagaag tgcaagcaaa gcagcaagca      600

tgaaccttaa gcactgtgct ttaagcatcc tgaaaaatga gtctccattg cttttataaa      660

atagcagaat tagctttgct tcaaaagaaa taggcttaat gttgaaataa tagattagtt      720

gggttttcac atgcaaacat tcaaaatgaa tacaaaatta aaatttgaac attatggtga      780

ttatggtgag gagaatggga tattaacata aaattatatt aataagtaga tatcgtagaa      840

atagtgttgt tacctgccaa gccatcctgt atacaccaat gattttacaa agaaaacacc      900

cttccctcct tctgccatta ctatggcaac ttaagtgtat ctgcagctct acattaaaaa      960

ggagaaagag aaataacctg tctctcattc ctaagttgcc tcattaattt tcatgaacaa     1020

gaatatgtac ctttttgatg ctatattact gcgattaaaa agttcttgca ggtaatgttt     1080

atgatatgtt aaacgttgta atttcctatc gtaattataa cattcccatt cttttgtaga     1140

tgaaacttct acatattgaa ccacagattt tctgagcttc taaatgtagc ctttcattgc     1200

acatttcagt gatcagaata gatatccttt tacacgcaca aaagcaatag attcattcag     1260

tggacaagtt ccttgtttaa ctacacagct atgatggaat gatatatcca agttccttgc     1320

ctcagtgaaa tatgcatatg tatatcatga aagtgggatg ccaagtaagc ttaaaatggc     1380

attctctagc aaagagatta gacttttaaa taactcttat aaaacaggtt ggcgatcatt     1440

tcccaagatt ggtttccctt gagtttttgc taaaacaaat cttagtagtt ttgcccgttt     1500

aaaacaactc acaatcgtaa atgctactat tcctaagata tcttaccttt ttatttcagt     1560

ttagccatgt attgtatgag tgtattagtc taagcagtga gaatcttttc tatgcctcta     1620

ttccagcaaa aagtagaagt atcaaataaa aagggcaact tttaaaatat taagcctgaa     1680

gacttctaaa aagacaagaa acatggccta aataaccaac atagatttac atagtaagtt     1740

tcacactacc ttattaccaa aagcaaacac ctcttacttt aaactacatt atcatgtata     1800

tctattgtat gctggtcttt actttttgcc aaaatcaaca tataatgaag agatgccttt     1860

gtttcatgag attcaaactt gatgctatgc tttaaaataa actcagtact tttagaaaca     1920

taa                                                                   1923


<210> 1830
<211> 746
<212> DNA
<213> Homo sapiens

<400> 1830
ctccggcact atgagcggct tcagcaccga ggagcgcgcc gcgcccttct ccctggagta       60

ccgagtcttc ctcaaaaatg agaaaggaca atatatatct ccatttcatg atattccaat      120

ttatgcagat aaggatgtgt ttcacatggt agttgaagta ccacgctggt ctaatgcaaa      180

aatggagatt gctacaaagg accctttaaa ccctattaaa caagatgtga aaaaaggaaa      240

acttcgctat gttgcgaatt tgttcccgta taaaggatat atctggaact atggtgccat      300

ccctcagact tgggaagacc cagggcacaa tgataaacat actggctgtt gtggtgacaa      360

tgacccaatt gatgtgtgtg aaattggaag caaggtatgt gcaagaggtg aaataattgg      420

cgtgaaagtt ctaggcatat tggctatgat tgacgaaggg gaaaccgact ggaaagtcat      480

tgccattaat gtggatgatc ctgatgcagc caattataat gtatgtaata gtgttgtgat      540

cctctgacat agcctctgcc tctggaccag ggatagtacc tcaagcctgt aatcccagtg      600

ctttgggaag ccaaggcagg aggattgctt gagcccagga gtttgagacc agcctgggca      660

acatgacgag accccatttc tacaaaaaat ttaaaaatta gctgggcgtg tgcatgctta      720

tagtcccagc tactcaggag gctgag                                           746


<210> 1831
<211> 1294
<212> DNA
<213> Homo sapiens

<400> 1831
agtgctcgca gtgcgcaggc gtggggctct ctccttgtca gtcggcgccg cgtgcgggct       60

ggtggctctg tggcagcggc ggcggcagga ctccggcact atgagcggct tcagcaccga      120

ggagcgcgcc gcgcccttct ccctggagta ccgagtcttc ctcaaaaatg agaaaggaca      180

atatatatct ccatttcatg atattccaat ttatgcagat aaggatgtgt ttcacatggt      240

agttgaagta ccacgctggt ctaatgcaaa aatggagatt gctacaaagg accctttaaa      300

ccctattaaa caagatgtga aaaaaggaaa acttcgctat gttgcgaatt tgttcccgta      360

taaaggatat atctggaact atggtgccat ccctcagact tgggaagacc cagggcacaa      420

tgataaacat actggctgtt gtggtgacaa tgacccaatt gatgtgtgtg aaattggaag      480

caaggtatgt gcaagaggtg aaataattgg cgtgaaagtt ctaggcatat tggctatgat      540

tgacgaaggg gaaaccgact ggaaagtcat tgccattaat gtggatgatc ctgatgcagc      600

caattataat gatatcaatg atgtcaaacg gctgaaacct ggctacttag aagctactgt      660

ggactggttt agaaggtata aggttcctga tggaaaacca gaaaatgagt ttgcgtttaa      720

tgcagaattt aaagataagg actttgccat tgatattatt aaaagcactc atgaccattg      780

gaaagcatta gtgactaaga aaacgaatgg aaaaggaatc agttgcatga atacaacttt      840

gtctgagagc cccttcaagt gtgatcctga tgctgccaga gccattgtgg atgctttacc      900

accaccctgt gaatctgcct gcacagtacc aacagacgtg gataagtggt tccatcacca      960

gaaaaactaa tgagatttct ctggaataca agctgatatt gctacatcgt gttcatctgg     1020

atgtattaga agtaaaagta gtagcttttc aaagctttaa atttgtagaa ctcatctaac     1080

taaagtaaat tctgctgtga ctaatccaat atactcagaa tgttatccat ctaaagcatt     1140

tttcatatct caactaagat aacttttagc acatgcttaa atatcaaagc agttgtcatt     1200

tggaagtcac ttgtgaatag atgtgcaagg ggagcacata ttggatgtat atgttaccat     1260

atgttaggaa ataaaattat tttgctgaaa cttg                                 1294


<210> 1832
<211> 2654
<212> DNA
<213> Homo sapiens

<400> 1832
gatgaggtaa tcgcgccgct gagaggcacg cgcagccggt gcctagccgg ttggtccctg       60

cgcccctgcc ccgccggcca ccgccccccc acaccgtccc ggccccggca gcctggcccc      120

accatgaccg agcggtgcag cctgtggagt gccctgtcgg ccgccgcctg ctgcttctac      180

cgcggctcct tcgtgcagtt ctccaaggag aagtacatcc tggactcatc gccagagaaa      240

ctccacaagg aattggagga ggagctcaaa ctcagcagca cggatctccg cagccatgcc      300

tggtaccatg gccgcatccc ccgagaggtc tcggagacct tggtacaacg caacggcgac      360

ttcctcatcc gggactcact caccagcctg ggcgactatg tgctcacgtg ccgctggcgc      420

aaccaggcct tgcacttcaa gatcaacaag gtggtggtga aggcaggcga gagctacaca      480

cacatccagt acctgtttga gcaggagagc tttgaccacg tgcccgccct cgtgcgctat      540

catgtgggca gccgcaaggc tgtgtcagag cagagtggtg ccatcatcta ctgcccggtg      600

aaccgcacct tcccactgcg ctacctcgag gccagctatg gcctgggaca ggggagtagc      660

aagcctgcta gccccgtcag cccctcaggc cccaagggca gccacatgaa gcggcgcagc      720

gtcaccatga ccgatgggct cactgctgac aaggtcaccc gcagcgatgg ctgccccacc      780

agtacgtcgc tgccccgccc tcgggactcc atccgcagct gtgccctcag catggaccag      840

atcccagacc tgcactcacc catgtcgccc atctccgaga gccctagctc ccctgcctac      900

agcactgtaa cccgtgtcca tgccgcccct gcagcccctt ctgccacagc attgcctgcc      960

tcccctgtcg cccgccgttc cagtgagccc cagctgtgtc ccggaagtgc cccaaagacc     1020

catggggagt cagacaaggg cccccacacc agcccctccc acacccttgg caaggcctcc     1080

ccgtcaccat cactcagcag ctacagtgac ccggactctg gccactactg ccagctccag     1140

cctcccgtgc gtggcagccg agagtgggca gcgactgaga cctccagcca gcaggccagg     1200

agctatgggg agaggctaaa ggaactgtca gaaaatgggg cccctgaagg ggactggggc     1260

aagaccttca cagtccccat cgtggaagtc acttcttcct tcaacccggc caccttccag     1320

tcactactga tccccaggga taaccggcca ctggaggtgg gccttctgcg caaggtcaag     1380

gagctgctgg cagaagtgga tgcccggacg ctggcccggc atgtcaccaa ggtggactgc     1440

ctggttgcta ggatactggg cgttaccaag gagatgcaga ccctaatggg agtccgctgg     1500

ggcatggaac tgctcaccct cccccatggc cggcagctac gcctagacct gctggaaagg     1560

ttccacacca tgtccatcat gctggccgtg gacatcctgg gctgcaccgg ctctgcggag     1620

gagcgggcag cgctgctgca caagaccatt cagctggcgg ccgagctgcg ggggactatg     1680

ggcaacatgt tcagcttcgc ggcggtcatg ggtgccctgg acatggccca gatttctcgg     1740

ctggagcaga catgggtgac cctgcggcag cgacacacag agggtgccat cctgtacgag     1800

aagaagctca agccttttct caagagcctc aacgagggca aagaaggccc gccgctgagc     1860

aacaccacgt ttcctcatgt gctgcccctc atcaccctgc tggagtgtga ctcggcccca     1920

ccagagggcc ctgagccctg gggcagcacg gagcacggcg tggaggtggt gctggctcac     1980

ctggaggccg cccgcacagt ggcacaccac ggaggcctgt accacaccaa tgctgaagtc     2040

aagctgcagg ggttccaggc ccggccggag ctcctggagg tgttcagcac ggagttccag     2100

atgcgccttc tctggggcag tcagggtgcc agcagcagcc aggcccggcg ctatgagaag     2160

ttcgacaagg tcctcactgc cctgtcccac aagctggaac ctgctgtccg ctccagcgag     2220

ctgtgacccc agggacattt cccctctgca gctgcggaca gcgtcagggg cagaggggca     2280

cacaactttc cccagagcac cccaaggaca ctgtgatcaa cccgagaatg ttctgggttc     2340

aactcaagca tctcccttgc acctccaggg tcctgcgtgg actctgggtt ccatcccacc     2400

tgctacatgc tcaccaggtc tccattgagg aagaacagga acgccggttc ccccaccagc     2460

ttttgctgct ccccttcctg ctggggttcc ctgttttcga gccatgggag gcaggctgct     2520

cacgcctcct cactctctgt ctgtccctca ccaacaccaa ggcctccatc tcactgtaaa     2580

taagtctctg ttctgtaaat agatgtacag aagccatgtt atttctttca tataataaac     2640

ttttatgact cttt                                                       2654


<210> 1833
<211> 2807
<212> DNA
<213> Homo sapiens

<400> 1833
atggcccctg ctctgccttc tcctcacaag gctgtcgccc gtcctgagct cctgctggac       60

actgcagccc actcaggaaa actgagggct ccagacggtg gagagggagc agaatgtgct      120

gggcacaatg gtggcccatc ttggggagtg gggcagggcc aaagccaaga gccttcccgg      180

cagggaatcc cacaggcccc atggctggtg tcctggcaga gacggggctt tccacccagc      240

tctttttgcc cagggccttt aaggactgag aagctcagag caggcaggtg cccgttgctt      300

ctctgcggtg gggctgctgg agagccagag gctggcagcg actatgtgaa gttctccaag      360

gagaagtaca tcctggactc atcgccagag aaactccaca aggaattgga ggaggagctc      420

aaactcagca gcacggatct ccgcagccat gcctggtacc atggccgcat cccccgagag      480

gtctcggaga ccttggtaca acgcaacggc gacttcctca tccgggactc actcaccagc      540

ctgggcgact atgtgctcac gtgccgctgg cgcaaccagg ccttgcactt caagatcaac      600

aaggtggtgg tgaaggcagg cgagagctac acacacatcc agtacctgtt tgagcaggag      660

agctttgacc acgtgcccgc cctcgtgcgc tatcatgtgg gcagccgcaa ggctgtgtca      720

gagcagagtg gtgccatcat ctactgcccg gtgaaccgca ccttcccact gcgctacctc      780

gaggccagct atggcctggg acaggggagt agcaagcctg ctagccccgt cagcccctca      840

ggccccaagg gcagccacat gaagcggcgc agcgtcacca tgaccgatgg gctcactgct      900

gacaaggtca cccgcagcga tggctgcccc accagtacgt cgctgccccg ccctcgggac      960

tccatccgca gctgtgccct cagcatggac cagatcccag acctgcactc acccatgtcg     1020

cccatctccg agagccctag ctcccctgcc tacagcactg taacccgtgt ccatgccgcc     1080

cctgcagccc cttctgccac agcattgcct gcctcccctg tcgcccgccg ttccagtgag     1140

ccccagctgt gtcccggaag tgccccaaag acccatgggg agtcagacaa gggcccccac     1200

accagcccct cccacaccct tggcaaggcc tccccgtcac catcactcag cagctacagt     1260

gacccggact ctggccacta ctgccagctc cagcctcccg tgcgtggcag ccgagagtgg     1320

gcagcgactg agacctccag ccagcaggcc aggagctatg gggagaggct aaaggaactg     1380

tcagaaaatg gggcccctga aggggactgg ggcaagacct tcacagtccc catcgtggaa     1440

gtcacttctt ccttcaaccc ggccaccttc cagtcactac tgatccccag ggataaccgg     1500

ccactggagg tgggccttct gcgcaaggtc aaggagctgc tggcagaagt ggatgcccgg     1560

acgctggccc ggcatgtcac caaggtggac tgcctggttg ctaggatact gggcgttacc     1620

aaggagatgc agaccctaat gggagtccgc tggggcatgg aactgctcac cctcccccat     1680

ggccggcagc tacgcctaga cctgctggaa aggttccaca ccatgtccat catgctggcc     1740

gtggacatcc tgggctgcac cggctctgcg gaggagcggg cagcgctgct gcacaagacc     1800

attcagctgg cggccgagct gcgggggact atgggcaaca tgttcagctt cgcggcggtc     1860

atgggtgccc tggacatggc ccagatttct cggctggagc agacatgggt gaccctgcgg     1920

cagcgacaca cagagggtgc catcctgtac gagaagaagc tcaagccttt tctcaagagc     1980

ctcaacgagg gcaaagaagg cccgccgctg agcaacacca cgtttcctca tgtgctgccc     2040

ctcatcaccc tgctggagtg tgactcggcc ccaccagagg gccctgagcc ctggggcagc     2100

acggagcacg gcgtggaggt ggtgctggct cacctggagg ccgcccgcac agtggcacac     2160

cacggaggcc tgtaccacac caatgctgaa gtcaagctgc aggggttcca ggcccggccg     2220

gagctcctgg aggtgttcag cacggagttc cagatgcgcc ttctctgggg cagtcagggt     2280

gccagcagca gccaggcccg gcgctatgag aagttcgaca aggtcctcac tgccctgtcc     2340

cacaagctgg aacctgctgt ccgctccagc gagctgtgac cccagggaca tttcccctct     2400

gcagctgcgg acagcgtcag gggcagaggg gcacacaact ttccccagag caccccaagg     2460

acactgtgat caacccgaga atgttctggg ttcaactcaa gcatctccct tgcacctcca     2520

gggtcctgcg tggactctgg gttccatccc acctgctaca tgctcaccag gtctccattg     2580

aggaagaaca ggaacgccgg ttcccccacc agcttttgct gctccccttc ctgctggggt     2640

tccctgtttt cgagccatgg gaggcaggct gctcacgcct cctcactctc tgtctgtccc     2700

tcaccaacac caaggcctcc atctcactgt aaataagtct ctgttctgta aatagatgta     2760

cagaagccat gttatttctt tcatataata aacttttatg actcttt                   2807


<210> 1834
<211> 2750
<212> DNA
<213> Homo sapiens

<400> 1834
gaggcggaga gcgtccttcc ctgccggtgg agtaggcggt ggagtggggc cgggcaagga       60

gcgcaggggc gtgtctgggg gcgtggtcta caggtcagtc tccgcccccg gagtccggca      120

ctgagctctg cagctcagtg gcccgagaaa ggcaggagcc gctgggttta ggaggtcccc      180

gggttgccgg cggcgacagc gggggaagca tgactgctgt gggccgaagg tgccccgcgc      240

tggggtcccg aggggctgct ggagagccag aggctggcag cgactatgtg aagttctcca      300

aggagaagta catcctggac tcatcgccag agaaactcca caaggaattg gaggaggagc      360

tcaaactcag cagcacggat ctccgcagcc atgcctggta ccatggccgc atcccccgag      420

aggtctcgga gaccttggta caacgcaacg gcgacttcct catccgggac tcactcacca      480

gcctgggcga ctatgtgctc acgtgccgct ggcgcaacca ggccttgcac ttcaagatca      540

acaaggtggt ggtgaaggca ggcgagagct acacacacat ccagtacctg tttgagcagg      600

agagctttga ccacgtgccc gccctcgtgc gctatcatgt gggcagccgc aaggctgtgt      660

cagagcagag tggtgccatc atctactgcc cggtgaaccg caccttccca ctgcgctacc      720

tcgaggccag ctatggcctg ggacagggga gtagcaagcc tgctagcccc gtcagcccct      780

caggccccaa gggcagccac atgaagcggc gcagcgtcac catgaccgat gggctcactg      840

ctgacaaggt cacccgcagc gatggctgcc ccaccagtac gtcgctgccc cgccctcggg      900

actccatccg cagctgtgcc ctcagcatgg accagatccc agacctgcac tcacccatgt      960

cgcccatctc cgagagccct agctcccctg cctacagcac tgtaacccgt gtccatgccg     1020

cccctgcagc cccttctgcc acagcattgc ctgcctcccc tgtcgcccgc cgttccagtg     1080

agccccagct gtgtcccgga agtgccccaa agacccatgg ggagtcagac aagggccccc     1140

acaccagccc ctcccacacc cttggcaagg cctccccgtc accatcactc agcagctaca     1200

gtgacccgga ctctggccac tactgccagc tccagcctcc cgtgcgtggc agccgagagt     1260

gggcagcgac tgagacctcc agccagcagg ccaggagcta tggggagagg ctaaaggaac     1320

tgtcagaaaa tggggcccct gaaggggact ggggcaagac cttcacagtc cccatcgtgg     1380

aagtcacttc ttccttcaac ccggccacct tccagtcact actgatcccc agggataacc     1440

ggccactgga ggtgggcctt ctgcgcaagg tcaaggagct gctggcagaa gtggatgccc     1500

ggacgctggc ccggcatgtc accaaggtgg actgcctggt tgctaggata ctgggcgtta     1560

ccaaggagat gcagacccta atgggagtcc gctggggcat ggaactgctc accctccccc     1620

atggccggca gctacgccta gacctgctgg aaaggttcca caccatgtcc atcatgctgg     1680

ccgtggacat cctgggctgc accggctctg cggaggagcg ggcagcgctg ctgcacaaga     1740

ccattcagct ggcggccgag ctgcggggga ctatgggcaa catgttcagc ttcgcggcgg     1800

tcatgggtgc cctggacatg gcccagattt ctcggctgga gcagacatgg gtgaccctgc     1860

ggcagcgaca cacagagggt gccatcctgt acgagaagaa gctcaagcct tttctcaaga     1920

gcctcaacga gggcaaagaa ggcccgccgc tgagcaacac cacgtttcct catgtgctgc     1980

ccctcatcac cctgctggag tgtgactcgg ccccaccaga gggccctgag ccctggggca     2040

gcacggagca cggcgtggag gtggtgctgg ctcacctgga ggccgcccgc acagtggcac     2100

accacggagg cctgtaccac accaatgctg aagtcaagct gcaggggttc caggcccggc     2160

cggagctcct ggaggtgttc agcacggagt tccagatgcg ccttctctgg ggcagtcagg     2220

gtgccagcag cagccaggcc cggcgctatg agaagttcga caaggtcctc actgccctgt     2280

cccacaagct ggaacctgct gtccgctcca gcgagctgtg accccaggga catttcccct     2340

ctgcagctgc ggacagcgtc aggggcagag gggcacacaa ctttccccag agcaccccaa     2400

ggacactgtg atcaacccga gaatgttctg ggttcaactc aagcatctcc cttgcacctc     2460

cagggtcctg cgtggactct gggttccatc ccacctgcta catgctcacc aggtctccat     2520

tgaggaagaa caggaacgcc ggttccccca ccagcttttg ctgctcccct tcctgctggg     2580

gttccctgtt ttcgagccat gggaggcagg ctgctcacgc ctcctcactc tctgtctgtc     2640

cctcaccaac accaaggcct ccatctcact gtaaataagt ctctgttctg taaatagatg     2700

tacagaagcc atgttatttc tttcatataa taaactttta tgactcttta                2750


<210> 1835
<211> 2841
<212> DNA
<213> Homo sapiens

<400> 1835
tgccagccca tggccgagcc tgccctcctc cccgccgccc agatggagag gctggcccca       60

gggcccctag cctcaccgtg tcctcggatc ccgcgggccc gcattgccag gcgctgcgcc      120

cagcgctggg ccgacctggg ctgcagctct ggcccctcct caggccgaat ggatcagctt      180

ccccagaaga atctcctgcg actacaccct gctggctctg ctggctgttc cactggagtg      240

gagagctcca gcatggatgg cttttggatg gaggtggaac agatccaaca gagagatgag      300

ctgagggaag aggacagtgg cgggaatgaa ggccagcttc cagaggaagg ggaagctgaa      360

tcccagtggc tgcaggacac aggcctgtcg ggcctccttg gtggcctggg cttggatggt      420

gatcaccagg agctcctgtc caccctgaca cagacccagg tggccgctgt gtgccgccgg      480

ctggacatct atgctcgctc agtgcgaaga caacacaaga cacctgtcag agatgtcagg      540

gatgtctttg gggtcttcaa ttcagggaaa atgtcgtcag agaatggcga ctccggtatg      600

aagggggccc agctcagttc cggggcctct aagtttcctc cagcagcaga gcctgggggg      660

ctgcaggagc aggctgggag ggaagaagcc ttcaacatgg actctgccta ctcagaacaa      720

gctgcggtgc tcctgcagag gagcaggcca tcccggggag gcacctctgc ctggggcaag      780

tgttccctgc cgaagtttac cgtccccaaa ggcagacttg gcgtgacgag gataggagac      840

ttgtccctgc aggatatgag gaaggtacct tctctggccc tcatagagct gaccgcgctc      900

tgtgacatcc tcggcttgga cctgaagagg agcaaggcgg ggaagtggaa agcggcagaa      960

actcgcctct ttggtgtgcc ccttgacagc ctgctagaag ctgaccacaa agtcctcccc     1020

agcacacagg tcccgctggt ccttcaagcc ctgctgtcct gtttggaaaa gagaggactg     1080

gacatggaag gcattctcag ggtgcccgga tcccaggcca gggtcaaggg gctggaacag     1140

aaactggaga gagacttcta tgctggcctt tttagctggg acgaggttca tcacaatgac     1200

gcctctgatt tgctcaaaag gttcatccgg aagctgccga cacctttgct cacggctgag     1260

tacctcccgg ccttcgccgt ggtgcctaac atccccaacc tgaagcagcg cctgcaggtt     1320

cttcacctgc tcatcctcat cctcccagaa cccaacagaa atgccttaaa ggcactgctg     1380

gaattcctca ggaaggtggt ggcccgggaa cagcacaaca agatgactct gaggaatgtt     1440

tccaccgtga tggcccctaa cctctttctg caccaagggc ggccccccaa gctccccaaa     1500

ggcaaggaga agcagctggc agaaggggca gccgaggtgg tgcagataat ggtgcactac     1560

caggatctgc tgtggacggt cgcctctttc ctggtcgccc aggtgcgaaa actgaacgac     1620

agtagcagca ggcgccccca gctctgcgac gcaggcctca agacttggct gcggaggatg     1680

cacgcagaca gggacaaggc gggggacggc ctcgaggcga ctcccaaggt ggcaaagatc     1740

caggtggtct ggcctatcaa ggaccccttg aaggtgcctc tcacccccag caccaaagtg     1800

gcccacgtcc tgaggcagtt cacagagcac ctcagccctg gttccaaggg tcaagaagac     1860

agtgaggaca tggacagcct ccttctacac cataggtcca tggagtcagc caacatcctc     1920

ctctatgaag ttggagggaa tatcaatgag catcgcctgg acccagatgc ctacctctta     1980

gatctgtacc gtgccaaccc gcatggtgag tgggtcctta aacagaaccc cacctaaacc     2040

ctgcgagtct caggagcagc ctggatgcct cctcctctcc cctgctggct ctgtgtccat     2100

gtacccagca tgagaacaaa gctattccag gggagggtct gagttttatt ccaaggcttc     2160

cttttctgaa atgcctctca gacccctcag aaatagactc aggggtggtg ctctctccac     2220

tcagagggga tgaggggcta gggcctcagg gaggggaggc caacactgta gccatgatca     2280

gccctggaag aactggacag aggaagaact tcccttcaca gctctcatgt tttaaccgtg     2340

cacacaatgc cctcactccc ctccaccctc cagccctcca gagagttgct tcctacacca     2400

agcttgctgt atgacgccac cacttggggc gcttggatct ccatgggctt ctgtctgtgg     2460

cttccagact ggaggaaaat taaaaatgca gtacctttat caagaggtag ttggggtctt     2520

ttccccccag gcaaaattgt ttcgaaagtg gccctacaat gtgtagtagc agcagcacca     2580

gagacaaaac caggagagct ctgtgacctt ggacaagccc cttgccctct cagaatcctt     2640

tcaggatgag gggctagggc ctcagggaga ggaagccaag attgtagcca tgaccagccc     2700

cgggagaaat ggacagagga agactttgct tcacagctct catgctttac atgttgattt     2760

gtacaatctt gtcattttgt aatatgatat aatatgtaaa cgtaattgtt taaacagtaa     2820

aggcacaaca agttcaatgt c                                               2841


<210> 1836
<211> 2234
<212> DNA
<213> Homo sapiens

<400> 1836
gtgctaaagg aaaccaacag cggcctaggg gtgaaaggac agccagggtt agatgttctg       60

aggaggcggg agcaaccgag agagcacgtg agcatctgtc ctttctaccc gttcctcttt      120

atctttagtg ttcagtagca gcggggatag cccggggccc ggtgtatggc cacggagtta      180

cagtgtccgg actccatgcc ctgtcacaac cagcaagtaa actctgcctc aaccccaagt      240

cccgagcagc tgcgacctgg cgatctgatc ctggaccacg cagggggaaa cagagcctcc      300

agggccaagg tgattctcct cacggggtac gcccattcta gcctgccggc cgagctggac      360

tctggggcct gcggcggctc cagcctcaac tcagagggca acagtggtag tggtgacagt      420

agcagctatg acgcaccagc tggcaactcc ttcctagagg actgcgaact ctcccggcag      480

atcggggcgc agcttaagct gctgcctatg aatgatcaga tacgggagct acagaccatc      540

atccgtgaca agacagccag tagaggtgac ttcatgtttt ctgcggatcg tttgatcaga      600

cttgttgtgg aagagggatt gaatcagctg ccatataaag aatgcatggt gaccactcca      660

acagggtaca agtatgaagg agtgaaattt gagaagggaa attgtggggt cagcataatg      720

agaagcggtg aggcaatgga acaaggttta cgagactgct gtcgatccat acgaattgga      780

aagatcctga ttcagagtga tgaggagaca caaagagcca aagtatatta tgccaaattc      840

cccccagaca tttaccggag aaaagtcctt ctgatgtatc caattctcag cactggaaat      900

actgtaattg aagctgtaaa ggttcttata gaacatggag ttcaacccag tgttatcatc      960

ctactcagtc tgttctccac tcctcatggt gagttcagca tgaggcagta actagggctc     1020

catatagtcc tgaggtgggt gccaaatcaa tcattcagga gtttccagag atcacaattt     1080

taactactga agttcatcct gttgcaccta cacattttgg acagaaatac tttggaacag     1140

actaagttat ttaagtaaaa taattatctt atgtaatatt acaatcatgt tttgattttc     1200

tatttgtttt actgattcac ttgagggtgg cagagaaaaa tgtgttaaaa tgctttttag     1260

ttttggaagt gggtatattt gaggttatat ctcatttagt tatttgttta ctgttggcac     1320

cgaattcaac aatgaagtat atgcaactct tacaaaacat aaattttaat aatattctaa     1380

tgcaaattac tgaaccctca gtgcattaaa attatttcct aatttatgag cctcttagtt     1440

tggaggttgc ttgaagccac aaataaaact caaatgagag tcagttcttt gtcccactgt     1500

agtttgcatt ttgtttagtt tggttttagc tctactaagg tttcacatat gtggctattg     1560

ccacattcct ctactgtttt ctttctgata ctggacatgc tagtaacttg gagaggagaa     1620

taaaagaatg tctcctggaa ttttacattc ccattaatgt cctcattcag ttggcagacc     1680

taggatgtat ggttaactct caggccatta tgtttttcat ggctcatttc ccaaactgca     1740

ttgttggtag gtgccttgct aagctgtaat gcagtgaaga agatggtggg gcatttttag     1800

taattggaac tgtaacatta atttacaaga ttgaaccggg gatgtctgga tgctgacaag     1860

ggagagccaa gtactgttaa tgccatcaat cctctaggaa ggaattggtg gtttttctga     1920

agtgtggggg aaagggtggt ttcttgctgg atttcatggc cagtaagtaa atttaaatgc     1980

ttcattttta atttggatgt ttctgctaga gacctttgat ttggaaatta gttattttgc     2040

atgtttgtca actgtatatg tatgaaaata gaaaaaaacc atgctttttg taaaaacccc     2100

taagatttgt atatgttcat ctttaggctt ctgaaaggga gagaaatcat attggaaatc     2160

agtgttggtg ttctgaaatc tgcttgtaaa actctcatct cattttacat tgatattaaa     2220

acattttaac agtg                                                       2234


<210> 1837
<211> 2186
<212> DNA
<213> Homo sapiens

<400> 1837
gtgtgctaaa ggaaaccaac agcggcctag gggtgaaagg acagccaggg ttagatgttc       60

tgaggaggcg ggagcaaccg agagagcacg tgagcatctg tcctttctac ccgttcctct      120

ttatctttag tgttcagtag cagcggggat agcccggggc ccggtgtatg gccacggagt      180

tacagtgtcc ggactccatg ccctgtcaca accagcaagt aaactctgcc tcaaccccaa      240

gtcccgagca gctgcgacct ggcgatctga tcctggacca cgcaggggga aacagagcct      300

ccagggccaa ggtgattctc ctcacggggt acgcccattc tagcctgccg gccgagctgg      360

actctggggc ctgcggcggc tccagcctca actcagaggg caacagtggt agtggtgaca      420

gtagcagcta tgacgcacca gctggcaact ccttcctaga ggactgcgaa ctctcccggc      480

agatcggggc gcagcttaag ctgctgccta tgaatgatca gatacgggag ctacagacca      540

tcatccgtga caagacagcc agtagaggtg acttcatgtt ttctgcggat cgtttgatca      600

gacttgttgt ggaagaggga ttgaatcagc tgccatataa agaatgcatg gtgaccactc      660

caacagggta caagtatgaa ggagtgaaat ttgagaaggg aaattgtggg gtcagcataa      720

tgagaagcgg tgaggcaatg gaacaaggtt tacgagactg ctgtcgatcc atacgaattg      780

gaaagatcct gattcagagt gatgaggaga cacaaagagc caaagtatat tatgccaaat      840

tccccccaga catttaccgg agaaaagtcc ttctgatgta tccaattctc agcactggaa      900

atactgtaat tgaagctgta aaggttctta tagaacatgg agttcaaccc agtgttatca      960

tcctactcag tctgttctcc actcctcatg gtgccaaatc aatcattcag gagtttccag     1020

agatcacaat tttaactact gaagttcatc ctgttgcacc tacacatttt ggacagaaat     1080

actttggaac agactaagtt atttaagtaa aataattatc ttatgtaata ttacaatcat     1140

gttttgattt tctatttgtt ttactgattc acttgagggt ggcagagaaa aatgtgttaa     1200

aatgcttttt agttttggaa gtgggtatat ttgaggttat atctcattta gttatttgtt     1260

tactgttggc accgaattca acaatgaagt atatgcaact cttacaaaac ataaatttta     1320

ataatattct aatgcaaatt actgaaccct cagtgcatta aaattatttc ctaatttatg     1380

agcctcttag tttggaggtt gcttgaagcc acaaataaaa ctcaaatgag agtcagttct     1440

ttgtcccact gtagtttgca ttttgtttag tttggtttta gctctactaa ggtttcacat     1500

atgtggctat tgccacattc ctctactgtt ttctttctga tactggacat gctagtaact     1560

tggagaggag aataaaagaa tgtctcctgg aattttacat tcccattaat gtcctcattc     1620

agttggcaga cctaggatgt atggttaact ctcaggccat tatgtttttc atggctcatt     1680

tcccaaactg cattgttggt aggtgccttg ctaagctgta atgcagtgaa gaagatggtg     1740

gggcattttt agtaattgga actgtaacat taatttacaa gattgaaccg gggatgtctg     1800

gatgctgaca agggagagcc aagtactgtt aatgccatca atcctctagg aaggaattgg     1860

tggtttttct gaagtgtggg ggaaagggtg gtttcttgct ggatttcatg gccagtaagt     1920

aaatttaaat gcttcatttt taatttggat gtttctgcta gagacctttg atttggaaat     1980

tagttatttt gcatgtttgt caactgtata tgtatgaaaa tagaaaaaaa ccatgctttt     2040

tgtaaaaacc cctaagattt gtatatgttc atctttaggc ttctgaaagg gagagaaatc     2100

atattggaaa tcagtgttgg tgttctgaaa tctgcttgta aaactctcat ctcattttac     2160

attgatatta aaacatttta acagtg                                          2186


<210> 1838
<211> 792
<212> DNA
<213> Homo sapiens

<400> 1838
atcccagacc aggctcgtgt ggctccttct tcctccgacc ctaaatcgaa gttctttgag       60

ctaatccagg gcactgagat tgacatcttc agctacaagc ccacactgct cacctctaaa      120

accctggaga agatccgccc tgtgtttgac taccgctgca tggtatctgg cagtgagcag      180

aagttcctca tcggcctggg gaaatcccag atctacacat gggatggccg ccagtcagac      240

cgctggatca agctagacct gaagacagag ctgccccggg acactctgct atctgtggaa      300

attgtgcatg agctgaaagg ggaggggaag gcccagagga agatcagtgc catccacatc      360

ctcgatgtcc ttgtgctgaa tggcaccgac gttcgggagc agcactttaa ccagcgaatt      420

cagcttgccg agaaatttgt gaaagccgtt tccaagccta gtcggcccga catgaatccc      480

atcagggtga aggaggtgta cagactggaa gagatggaga agatttttgt caggttggag      540

atgaagatca tcaagggctc cagtggcacc ccaaagctca gctacacagg gcgtgatgac      600

cggcactttg tacccatggg cctctacatc gtcaggacag tgaatgagcc ctggactatg      660

ggattcagca aaagcttcaa gaagaagttc ttctacaaca agaaaaccaa ggactctact      720

tttgacctcc ctgcagactc cattgcccca tttcacctcc ccagccttgc ctgcctgtcg      780

aagatggatt aa                                                          792


<210> 1839
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 1839
atgaagagga gaactgaccc agaatgcact gcccccatca agaaacagaa aaaaagagtt       60

gcagagcttg ccctgagcct cagctccacg tccgatgatg aacctccctc ctctgtcagt      120

catggagcaa aagcatctac tacaagcctt agtgggtctg atagtgagac cgaggggaaa      180

caacacagct ctgactcttt tgacgatgca ttcaaagcag actctcttgt ggaaggaact      240

tcttctcgct attccatgta taatagcgtc tcccagaagc ttatggccaa gatgggcttc      300

agggaaggtg aaggattggg taaatacagc cagggtcgga aggacatcgt tgaggcttcc      360

agtcagaaag gtcgaagagg cttgggtctg acactccggg gctttgacca ggagctgaac      420

gtggactggc gagatgagcc agagcccagt gcttgtgagc aggtgtcatg gtttccagaa      480

tgtaccactg aaattcctga cactcaggaa atgagcgatt ggatggtggt gggaaagaga      540

aagatgatta ttgaagatga aacagagttt tgtggggaag agctgcttca cagtgtgttg      600

cagtgtaaga agccactggt gaaggaccgg gaagctgagc ttctgtactt tgctgatgtc      660

tgcgcaggcc caggtggctt ctcagagtat gtgctgtgga ggaagaagtg gcatgcaaag      720

ggctttggaa tgactttgaa gggccctaat gacttcaagc tggaggactt ctactctgct      780

tccagtgaac tcttcgaacc ctactatggt gagggtggga ttgatggaga tggagatatc      840

acccgcccag agaacatctc tgcttttcgg aattttgtcc tggataacac agatcgcaag      900

ggtgtccatt ttctgatggc tgatgggggt ttctcggtgg aggggcagga gaacctgcag      960

gagatcctca gcaagcagct gcttctgtgt cagttcctca tggcgctgtc cattgtccgg     1020

acaggaggcc acttcatctg taaaaccttt gacctgttca caccgtttag tgtggggctt     1080

gtctacctgc tgtactgctg ctttgaacga gtttgt                               1116


<210> 1840
<211> 616
<212> DNA
<213> Homo sapiens

<400> 1840
atggctggct acctgagtga atcggacttt gtgatggtgg aggagggctt cagtacccga       60

gacctgctga aggaactcac tctgggggcc tcacaggcca ccacggacga ggtagctgcc      120

ttcttcgtgg ctgacctggg tgccatagtg aggaagcact tttgctttct gaagtgcctg      180

ccacgagtcc ggccctttta tgctgtcaag tgcaacagca gcccaggtgt gctgaaggtt      240

ctggcccagc tggggctggg ctttagctgt gccaacaaga ttgcttccgt gatcaactca      300

gccttggacc tgtacttccc agagggctgt ggcgtggaca tctttgctga gctggggcgc      360

tactacgtga cctcggcctt cactgtggca gtcagcatca ttgccaagaa ggaggttctg      420

ctagaccagc ctggcaggga ggaggaaaat ggttccacct ccaagaccat cgtgtaccac      480

cttgatgagg gcgtgtatgg gatcttcaac tcagtcctgt ttgacaacat ctgccctacc      540

cccatcctgc agaagtctaa gaaccactca ccctgctaca tgtctctaga gtccattcat      600

ttcattgccg tgtagc                                                      616


<210> 1841
<211> 1443
<212> DNA
<213> Homo sapiens

<400> 1841
atggctggct acctgagtga atcggacttt gtgatggtgg aggagggctt cagtacccga       60

gacctgctga aggaactcac tctgggggcc tcacaggcca ccacggacga ggtagctgcc      120

ttcttcgtgg ctgacctggg tgccatagtg aggaagcact tttgctttct gaagtgcctg      180

ccacgagtcc ggccctttta tgctgtcaag tgcaacagca gcccaggtgt gctgaaggtt      240

ctggcccagc tggggctggg ctttagctgt gccaacaagg cagagatgga gttggtccag      300

catattggaa tccctgccag taagatcatc tgcgccaacc cctgtaagca aattgcacag      360

atcaaatatg ctgccaagca tgggatccag ctgctgagct ttgacaatga gatggagctg      420

gcaaaggtgg taaagagcca ccccagtgcc aagatggttc tgtgcattgc taccgatgac      480

tcccactccc tgagctgcct gagcctaaag tttggagtgt cactgaaatc ctgcagacac      540

ctgcttgaaa atgcgaagaa gcaccatgtg gaggtggtgg gtgtgagttt tcacattggc      600

agtggctgtc ctgaccctca ggcctatgct cagtccatcg cagacgcccg gctcgtgttt      660

gaaatgggca ccgagctggg tcacaagatg cacgttctgg accttggtgg tggcttccct      720

ggcacagaag gggccaaagt gagatttgaa gagattgctt ccgtgatcaa ctcagccttg      780

gacctgtact tcccagaggg ctgtggcgtg gacatctttg ctgagctggg gcgctactac      840

gtgacctcgg ccttcactgt ggcagtcagc atcattgcca agaaggaggt tctgctagac      900

cagcctggca gggaggcccc actaccaccc cctcacattg ctacttgtgc tgcctctgaa      960

ccctcccctc ctgcagagga aaatggttcc acctccaaga ccatcgtgta ccaccttgat     1020

gagggcgtgt atgggatctt caactcagtc ctgtttgaca acatctgccc tacccccatc     1080

ctgcagaaga aaccatccac ggagcagccc ctgtacagca gcagcctgtg gggcccggcg     1140

gttgatggct gtgattgcgt ggctgagggc ctgtggctgc cgcaactaca cgtaggggac     1200

tggctggtct ttgacaacat gggcgcctac actgtgggca tgggttcccc cttttggggg     1260

acccaggcct gccacatcac ctatgccatg tcccgggtgg cctgggaagc gctgcgaagg     1320

cagctgatgg ctgcagaaca ggaggatgac gtggagggtg tgtgcaagcc tctgtcctgc     1380

ggctgggaga tcacagacac cctgtgcgtg ggccctgtct tcaccccagc gagcatcatg     1440

tga                                                                   1443


<210> 1842
<211> 2048
<212> DNA
<213> Homo sapiens

<400> 1842
ggctgctggg ctggcggggc gcaggccgcg ggacccgagc ccggggaagc gagagagcgg       60

aggcgccgag gatccgattc actccctggg gagacctatg ggccgaagcc gtgtaaatgc      120

gttttaagag gcctcggctc cgcaactgcc actcctcctc ggggtgttgc acaagtttcg      180

aggtcaccgg cgaccccccc tagcagcgcg cctggctctg gcccccgcga aggaggacgg      240

agtttgtgtg ttgcatactt tctaaggcgg cggctgcagc agcggctcca tccagcccgt      300

cagctcctcc tgcaaggcat ggctggctac ctgagtgaat cggactttgt gatggtggag      360

gagggcttca gtacccgaga cctgctgaag gaactcactc tgggggcctc acaggccacc      420

acggacgagg tagctgcctt cttcgtggct gacctgggtg ccatagtgag gaagcacttt      480

tgctttctga agtgcctgcc acgagtccgg cccttttatg ctgtcaagtg caacagcagc      540

ccaggtgtgc tgaaggttct ggcccagctg gggctgggct ttagctgtgc caacaaggca      600

gagatggagt tggtccagca tattggaatc cctgccagta agatcatctg cgccaacccc      660

tgtaagcaaa ttgcacagat caaatatgct gccaagcatg ggatccagct gctgagcttt      720

gacaatgaga tggagctggc aaaggtggta aagagccacc ccagtgccaa gatggttctg      780

tgcattgcta ccgatgactc ccactccctg agctgcctga gcctaaagtt tggagtgtca      840

ctgaaatcct gcagacacct gcttgaaaat gcgaagaagc accatgtgga ggtggtgggt      900

gtgagttttc acattggcag tggctgtcct gaccctcagg cctatgctca gtccatcgca      960

gacgcccggc tcgtgtttga aatgggcacc gagctgggtc acaagatgca cgttctggac     1020

cttggtggtg gcttccctgg cacagaaggg gccaaagtga gatttgaaga gattgcttcc     1080

gtgatcaact cagccttgga cctgtacttc ccagagggct gtggcgtgga catctttgct     1140

gagctggggc gctactacgt gacctcggcc ttcactgtgg cagtcagcat cattgccaag     1200

aaggaggttc tgctagacca gcctggcagg gaggaggaaa atggttccac ctccaagacc     1260

atcgtgtacc accttgatga gggcgtgtat gggatcttca actcagtcct gtttgacaac     1320

atctgcccta cccccatcct gcagaagaaa ccatccacgg agcagcccct gtacagcagc     1380

agcctgtggg gcccggcggt tgatggctgt gattgcgtgg ctgagggcct gtggctgccg     1440

caactacacg taggggactg gctggtcttt gacaacatgg gcgcctacac tgtgggcatg     1500

ggttccccct tttgggggac ccaggcctgc cacatcacct atgccatgtc ccgggtggcc     1560

tgggaagcgc tgcgaaggca gctgatggct gcagaacagg aggatgacgt ggagggtgtg     1620

tgcaagcctc tgtcctgcgg ctgggagatc acagacaccc tgtgcgtggg ccctgtcttc     1680

accccagcga gcatcatgtg agtgggcctc gttccccccg gagaatccca gcggggcctc     1740

agagatgcat ctgggagagg tggggaagat ggcaggcaag ggtacccttg gccaggactc     1800

tggtgcccac cctgccaccc ccgcgctcca cctgcagtgt ttctgccctg taaataggac     1860

cagtcttaca ctcgctgtag ttcaagtatg caacataaat cctgttcctt ccagctgtgt     1920

ctgcctcctc tgcagtgcaa ggggcctggt cagccaggtg tgggggtgtt cttggggtct     1980

cctttggtct ccttcccacc tttgtaaata taatgcaaat aaataaatat ttaggttttt     2040

aaaaactg                                                              2048


<210> 1843
<211> 4033
<212> DNA
<213> Homo sapiens

<400> 1843
cgcagtactg gacccgagcg cgacggtgcg gctggcggac ccgggctggc ttgtggggaa       60

acgaaactga gggaggaggc ggcggctctg gcagcggcgg cgacagtgtc ggcctgaccc      120

cccctccgct ccccggcagc tcgctctctc ccctcagctt aacgatgaag aggagaactg      180

acccagaatg cactgccccc atcaagaaac agaaaaaaag agttgcagag cttgccctga      240

gcctcagctc cacgtccgat gatgaacctc cctcctctgt cagtcatgga gcaaaagcat      300

ctactacaag ccttagtggg tctgatagtg agaccgaggg gaaacaacac agctctgact      360

cttttgacga tgcattcaaa gcagactctc ttgtggaagg aacttcttct cgctattcca      420

tgtataatag cgtctcccag aagcttatgg ccaagatggg cttcagggaa ggtgaaggat      480

tgggtaaata cagccagggt cggaaggaca tcgttgaggc ttccagtcag aaaggtcgaa      540

gaggcttggg tctgacactc cggggctttg accaggagct gaacgtggac tggcgagatg      600

agccagagcc cagtgcttgt gagcaggtgt catggtttcc agaatgtacc actgaaattc      660

ctgacactca ggaaatgagc gattggatgg tggtgggaaa gagaaagatg attattgaag      720

atgaaacaga gttttgtggg gaagagctgc ttcacagtgt gttgcagtgt aagagcgtgt      780

ttgatgtctt ggatggggaa gagatgcggc gagctcggac tcgggccaat ccctatgaga      840

tgatccgagg agtcttcttt ctaaacaggg cagcaatgaa gatggctaac atggattttg      900

tatttgatcg catgttcaca aatccgcggg actcttatgg gaagccactg gtgaaggacc      960

gggaagctga gcttctgtac tttgctgatg tctgcgcagg cccaggtggc ttctcagagt     1020

atgtgctgtg gaggaagaag tggcatgcaa agggctttgg aatgactttg aagggcccta     1080

atgacttcaa gctggaggac ttctactctg cttccagtga actcttcgaa ccctactatg     1140

gtgagggtgg gattgatgga gatggagata tcacccgccc agagaacatc tctgcttttc     1200

ggaattttgt cctggataac acagatcgca agggtgtcca ttttctgatg gctgatgggg     1260

gtttctcggt ggaggggcag gagaacctgc aggagatcct cagcaagcag ctgcttctgt     1320

gtcagttcct catggcgctg tccattgtcc ggacaggagg ccacttcatc tgtaaaacct     1380

ttgacctgtt cacaccgttt agtgtggggc ttgtctacct gctgtactgc tgctttgaac     1440

gagtttgtct cttcaagcct attaccagcc gtcctgccaa ctcagagagg tatgtggtgt     1500

gcaagggcct gaaggtgggc atagatgatg ttcgggatta cctcttcgca gtgaatatta     1560

aactcaatca gctgcggaac acggattccg acgtcaactt ggtggtcccc ctggaggtga     1620

tcaagggaga ccatgaattt actgactaca tgatacggtc caatgagagc cactgtagtc     1680

tgcagatcaa agctctggcg aaaatccatg cctttgttca agacacgaca ctgagtgagc     1740

ctcgacaggc agagatacgg aaggagtgcc tccgactctg ggggatccca gaccaggctc     1800

gtgtggctcc ttcttcctcc gaccctaaat cgaagttctt tgagctaatc cagggcactg     1860

agattgacat cttcagctac aagcccacac tgctcacctc taaaaccctg gagaagatcc     1920

gccctgtgtt tgactaccgc tgcatggtat ctggcagtga gcagaagttc ctcatcggcc     1980

tggggaaatc ccagatctac acatgggatg gccgccagtc agaccgctgg atcaagctag     2040

acctgaagac agagctgccc cgggacactc tgctatctgt ggaaattgtg catgagctga     2100

aaggggaggg gaaggcccag aggaagatca gtgccatcca catcctcgat gtccttgtgc     2160

tgaatggcac cgacgttcgg gagcagcact ttaaccagcg aattcagctt gccgagaaat     2220

ttgtgaaagc cgtttccaag cctagtcggc ccgacatgaa tcccatcagg gtgaaggagg     2280

tgtacagact ggaagagatg gagaagattt ttgtcaggtt ggagatgaag atcatcaagg     2340

gctccagtgg caccccaaag ctcagctaca cagggcgtga tgaccggcac tttgtaccca     2400

tgggcctcta catcgtcagg acagtgaatg agccctggac tatgggattc agcaaaagct     2460

tcaagaagaa gttcttctac aacaagaaaa ccaaggactc tacttttgac ctccctgcag     2520

actccattgc cccatttcac atttgctact atggccggct cttctgggag tggggggatg     2580

gcattcgtgt gcatgactcc cagaagcccc aggaccagga caagctgtcc aaggaggacg     2640

tcctctcctt catccagatg cacagggcct aagagcctca gaatgtgcca cccctgcaga     2700

atgccctgtc attcctgaga tggggccacc tggggcccac agtgctggct tcttccccct     2760

cttgaaaagg gactggggag cattgcacct ggcatgagga gtgggtggcc tcctctccat     2820

cccctgaaga gctcaggcag ggccctgcag agaacactca tgttccttct gggacacctg     2880

cctgggaact ttcccctgcc aggactcagc ctgaaggaag ctgctcctga ggcaggtatg     2940

aggtcagtgc ctagggcacg tgggactgat ggaggacata tcagagtggc agagctgtgg     3000

gctctgctgt tctctcctgc atcctgtaga ctcacttttc tgagttccat gcactgccct     3060

gagggtagcc atgcccttgc tttgcccaac tttttattgg gccatccctg agtgggtgga     3120

gacctgctgt catgagctgg ccaggagaac ctgctataaa aaaatcaagg ttttgtttct     3180

ttgaacttac tctgttttga tgccaaattg gagaccattt tcttgtctcc ttcccccact     3240

catcctggcc ttccctggag ttcttcctag cccagagctc tgacagtcca gcagggtggg     3300

aaggagggag tttgggcaaa ctctcatccc tgataccaca ttgagatcct gggagccctc     3360

ttttcgtact gagtatggag ttgtagagcc atcctaggtg ccatcccctt ttggtccaaa     3420

cattgggcag cgctagatgg caggaagcag ccttgaagac ccgtctttcc cccacagcag     3480

caggggcccc agcagtaaca aagggtacct ccaggggttt gggtagcgct gccctctggc     3540

agtcatgcac cgctgtctgc catagccgct ctagggtctt ggcagaattc tgagcttgaa     3600

gtgcagctcc cttactaccc tttcccttcc tttttcttcc ctaataggag gtacaatctg     3660

cttttgtttg tcgttaagtg gtcactccca tttcctttat cttggccgac aacacagaga     3720

ggagggggag ctgggcagta gcttggggtg ggggtgggca cctgtggttg tttttaatgg     3780

gaaatacctc tcagagatgt tcatgcaggc tccctagggc cccatcccag tgccaggctg     3840

gtttccatgg agatagggca ctgaggctcc cgtgaggttg gaatcgactt caccatgggg     3900

gtccttcagc cagcatccag ctccccaccc ccaggctggc agtagcactg ctgagatgct     3960

gtatttccac ccaattctgg gtatatcagt gtgtcttgca gaatcttgga tcattaaaga     4020

taaacatatt ttt                                                        4033


<210> 1844
<211> 522
<212> DNA
<213> Homo sapiens

<400> 1844
gcaagaactc ctgaaagaga aaacacttgc tgagcagaat ttggaggata ccagacaaca       60

gctcttggca gccagaagca gccaggctaa ggccattaac accctggaga ctcgggtgag      120

agaactggag cagaccttgc aggcctctga ggagcagctc caacagagca agggcattgt      180

ggctgcccag gaaactcaga tacaggagct cgtaagtgct tattggagct gctgcattcc      240

aggcccttaa tgctttctct ccaggccttt gcagatgctc caaactcatt ccgaacttcg      300

gcaacggtac ctggacctgc ccatagatac agttcttgtg ctggatgtga gcaggccagc      360

agcagggggt ggagggagtc aggacctaat ggtgggcctg agttacctgg gaggtgcacc      420

agcagctcct ttccacctta catcccacct tctggtccag cctggtcctg gggctgtcag      480

aggtggcagc tccgctagga gtcaagcctc aacttgcaat ca                         522


<210> 1845
<211> 4801
<212> DNA
<213> Homo sapiens

<400> 1845
gcgctgggag acgtgcggtt ccgggtcgct gctcggctcg ccggctgggc ggtgggggtt       60

ggtgacgcgg gccggggctc acgagaggcc cgggaggcgg ggctttgctg gcttcccaga      120

gagaggcagg acagaatgct ttgacctcca agctgtttta aatctagtag ataagccaga      180

tcctgtgttg ccataagccc ttggcccaca tttaagtggg aatgcagcta gcttggatgt      240

ctgaaacttt gtaggcgcct ctgtctgaat cctgaacaca ggcaccagga ctactgagag      300

ctcgtcatct gtgcaggata gccacacagc aaacatgttt gcaaaactga agaagaaaat      360

tgcagaagag actgctgttg ctcagaggcc aggaggtgct actaggatcc cacggtctgt      420

gagcaaggaa tcagttgcct caatgggagc tgactcagga gatgactttg cttccgatgg      480

aagcagctcc agagaagatc tttcatccca gcttctgaga aggaatgaac agatacggaa      540

gttagaggcc agactttctg actatgctga acaggtccga aacttgcaga agataaaaga      600

gaagcttgaa attgcattag aaaaacacca ggattcttcc atgcggaaat ttcaagagca      660

gaatgagaca ttccaagcca acagagccaa aatggcagaa ggactggctt tggcattagc      720

cagaaaggac caggaatggt cagaaaagat ggatcagctt gaaaaggaga aaaatattct      780

gacagcccag ttacaggaaa tgaagaacca gagtatgaat cttttccaaa ggagagatga      840

aatggatgaa ttagaggggt tccagcagca ggaactaagt aaaataaagc acatgctttt      900

aaaaaaagaa gaaagtctag ggaaaatgga acaagaattg gaggcacgaa ccagagaact      960

tagtcgtacc caggaggagt tgatgaactc caatcagatg tcatcagact taagccagaa     1020

gctagaagaa ttgcagagac actactcaac gctggaagag cagagagatc atgtgatagc     1080

ttcaaaaaca ggtgcagaaa gtaagatcac agccctggaa caaaaggaac aagagctcca     1140

agcactcatt cagcagcttt ccattgattt gcaaaaggtc actgctgaaa ctcaagagaa     1200

agaagacgtt atcacacatt tgcaagagaa ggttgcatcc ttggagaaga gactagaaca     1260

gaacttatca ggagaagaac acttgcaaga actcctgaaa gagaaaacac ttgctgagca     1320

gaatttggag gataccagac aacagctctt ggcagccaga agcagccagg ctaaggccat     1380

taacaccctg gagactcggg tgagagaact ggagcagacc ttgcaggcct ctgaggagca     1440

gctccaacag agcaagggca ttgtggctgc ccaggaaact cagatacagg agctcgctgc     1500

cgccaaccag gagagcagcc atgtgcagca gcaggccctt gctctggagc agcagttctt     1560

ggagcgcacc caggcgctag aagcccagat agtggccctg gagagaacgc gggcagctga     1620

ccagaccacc gcagagcaag ggatgagaca actggagcaa gaaaatgcag cccttaaaga     1680

atgcaggaat gaatatgaac gttctttaca aaatcaccaa tttgaactaa agaagctgaa     1740

ggaagaatgg agccaaagag aaattgtgag cgtggccatg gctcaagccc tggaggaggt     1800

gcggaagcaa agggaagagt tccagcaaca ggcagctaac ctgacagcca taatagacga     1860

gaaggaacag aatctgcggg aaaaaaccga agtgcttctc cagaaagagc aggagattct     1920

ccagctggag cgaggtcaca actctgccct gctgcagata caccagctgc aggccgagct     1980

ggaggccctg aggaccctca aggcggagga ggctgcagtg gtcgcggagc aggaggacct     2040

gctgaggctg cggggcccat tgcaggccga agcactctca gtcaatgagt cgcacgtgac     2100

ctcgagggcc atgcaggacc ctgtgttcca gcttccaact gcaggaagaa caccaaatgg     2160

tgaggttggg gccatggatc tcacacagct acagaaggag aaacaggact tggagcagca     2220

acttctggag aaaaataaga ccataaagca gatgcagcag cggatgctgg agctccggaa     2280

gactctgcag aaggagctga aaatcagacc cgataatgag ctcttcgaag tccgggagaa     2340

acctggacct gagatggcaa acatggcgcc ttccgtcacg aataacactg acctgacaga     2400

tgcccgcgag atcaactttg agtaccttaa acatgtggtt ttaaaattca tgtcttgtcg     2460

cgaatccgag gcttttcatc ttataaaagc tgtgtcagtg ttgctgaact tttcccaaga     2520

ggaggagaac atgctcaagg aaactctgga atataagatg tcatggtttg ggtccaaacc     2580

agctcccaag ggcagcatcc ggccgtctat ctcaaaccct cggataccat ggtcctagag     2640

gggactaccc aaggatggag ctccgtgggt tgacactttt tctgtgaaaa gaacactgac     2700

acaccagtct gggtgggttt ttaatcactg taactgcagt attttgtaca agtgtctaaa     2760

cattgtttac aagactaagg cccacttccc tgcaggctga cctgaacctc agggggtagc     2820

tgatcctgtc attctggtca ccaaacagga gggtcctggc actacccaga tttccacagt     2880

gctgctaata tcccagctcc agccagcacc ccatctgcac ctgaatcctc taacttcacg     2940

gtagcactta cagctgaagc catcagcatc tggcaggcac acctgagtca ccatgtagcg     3000

ctgctactgg aggtagagac ggccctttga gatggtgccc agcaggccaa acccacctgc     3060

ctctgccagg aacagccaac tccatgggaa ctctatggga gtggctttta aaaattcaga     3120

tgagttagaa gctttttatc ccttcctctc aagaaaatat tctttcaccc tgtctctcaa     3180

accacctaga actttagagg atccatcttt aagggtcggt gtggatgaat gagaaaatgc     3240

acctttctga cagtatctcc actttactta agaaaactag caaatatatg aaaagaccct     3300

tagtaccaaa tacactcaat tgccttttta atgaatgtac ttgtcttgga taggttgctg     3360

gtaaaccatt ttaaactatt ttttatagct gaagttcttc actactataa acatgtcttc     3420

tgtactataa aatccattta actggtgttc ttaaaatcag agcgtccaga ggaaattctt     3480

cctaaaacta ggattcctgt tcctttgtct tctcactcgc actctggcac tgctccctct     3540

gaagtgcagt gggatctcgt gtgctttgtc ttgattctgt gctgcgctgc cgctgggcga     3600

tgcagaccac ctgtcttcta ctgaaggaca gtccgctgtc tccagtgggg gcagcagctg     3660

tcccccagcc tcgatggaga cactggggca gtctgccttg tctgtggagc tgctctctct     3720

ccctcatccc accccaaata cttaaaatga cactacaccc agacggcgcc cagctggctg     3780

cagcacttgt agcatgcaca tgactctggt agtaaccaac aaaaacttgt tttatggatt     3840

cctcgtttac tgaggaaagg gaacatgctg gttctggaaa agccacaata ttgaatctaa     3900

aaggaaaccg tttattgttt gatgaaagtt tcactggtta aataaaaaac taaattaata     3960

actggagcct ctaaatttat tatccattat ccagtgatgg aaagttgtat ttctcaatca     4020

tgcttagggc caaaataggt atataaaatg tgtcacagaa aaacacgcat ttgcaacgtt     4080

aacctaacga aatttccatg aagaaccaag tcagggcagc atctccttag tcccagctca     4140

ggctctctgc cttccagagg ccgcttctcc agtgactaac ctcctcctct ggctcctcct     4200

tgcagacagt tatcccttgt ttagaacacg aatttccatt tacctggtgg gaacacgaaa     4260

caggagtctc ttctgttctg caagtttgat gggtaagagg tagccttttt tcaaagtagg     4320

atttcctttt tcaactgttc caggaaagaa tctctaagac tgggtagctc acagccagcc     4380

aaaggcagct acatttccac agaagcccat ccgctgcctc cgtggcttct ccagccattg     4440

aactggtccc acacgcaccc caggccccac tcctcggcag tttcaggtgt agctgtgggg     4500

cccgttccta ggtctgtact cactttaggg aggcttcact gactaggctt tcctcctgca     4560

tgttgaattt ccttcagctt taagaggaag agtggaataa atattctaag tgatttaatg     4620

cactttgact tgtataaaac tttctgtgtt agcgacggta tctatagccc tttatacgag     4680

cgatggatct tgagctctcc ttccatgttg taaataggga ttgtattctt gaaaactgct     4740

gtagcaaatt catctgtggt gcaatacact ttttgattaa agctcttcaa tccagatgca     4800

a                                                                     4801


<210> 1846
<211> 488
<212> DNA
<213> Homo sapiens

<400> 1846
ggccaagatc aaggctcgag atcttcgcgg gaagaagaag gaggagctgc tgaaacagct       60

ggacgacctg aaggtggagc tgtcccagct gcgcgtcgcc aaagtgacag gcggtgcggc      120

ctccaagctc tctaagatcc gagtcgtccg gaaatccatt gcccgtgttc tcacagttat      180

taaccagact cagaaagaaa acctcaggaa attctacaag gcagcagctg gtgggccctg      240

catacagatg gacagagtac tgcctcagcc cccagcatgc tcttgctaac cagagccgag      300

ggcaagaagt acaagcccct ggacctgcgg cctaagaaga cacgtgccat gcgccgccgg      360

ctcaacaagc acgaggagaa cctgaagacc aagaagcagc agcggaagga gcggctgtac      420

ccgctgcgga agtacgcggt caaggcctga ggggcgcatt gtcaataaag cacagctggc      480

tgagactg                                                               488


<210> 1847
<211> 3821
<212> DNA
<213> Homo sapiens

<400> 1847
gaaagctgcc gctgaagctg ccgccgttgc ctccgccgcc aagagtgagc gagcggaccc       60

gcgatggaga ccatggcgag cccagggaaa gacaattatc gaatgaagag ctataagaac      120

aatgctctaa accctgaaga aatgagacga agaagagagg aagagggcat tcagctccgg      180

aagcagaagc gagagcaaca actttttaaa cggagaaatg tggagctgat taatgaagaa      240

gctgccatgt tcgatagtct tctcatggac tcttatgtga gctctaccac tggggagagt      300

gtgatcacaa gagagatggt ggagatgctc ttttctgatg attctgacct gcagttagca      360

accacacaga aattccggaa actgctctcc aaagagccta gtcctccaat agatgaagtt      420

atcaacactc caagagtggt ggatcggttc gtggagtttc tgaagaggaa tgagaattgt      480

acattacagg cagtctgggc actgggaaac atagctggag atagctctgt ttgccgagat      540

tacgtcttga actgttccat ccttaatcct ttgttaacac tccttaccaa gtccacacga      600

ctgacgatga cacggaatgc agtctgggcc ctgtcaaatc tctgccgagg gaaaaaccca      660

cccccagagt ttgcaaaggt ctctccttgt ttgcctgtac tgtctcgcct actcttcagc      720

agcgactcgg acttgctggc agatgcttgc tgggcccttt cttatctgtc tgatggcccc      780

aatgagaaga tccaggcagt catagactcc ggagtctgcc ggagattggt agagctgctg      840

atgcacaatg attacaaagt ggcttctcct gccctgagag ccgtgggtaa catcgtcact      900

ggggatgaca tccagaccca ggtcattctt aactgttcag ccctaccttg ccttctccac      960

ttgttgagca gtcccaagga gtcaatccgg aaggaagctt gctggactat ttcaaatatt     1020

actgctggca acagggctca aatacaggct gttatagatg caaatatctt ccctgtgttg     1080

atcgaaatcc ttcagaaagc agagtttcgt acaaggaaag aggcagcctg ggccatcacc     1140

aatgccacat caggaggaac ccctgagcag atcaggtacc tggtctcact gggctgcatc     1200

aaacccctat gtgacttgct gactgtaatg gattcgaaga ttgtgcaagt ggccctcaat     1260

ggactggaga acatcctgcg gcttggagag caagagggca agcgcagtgg ctcaggggtc     1320

aatccttatt gtggcctcat agaggaagcc tatggcttgg ataaaattga gtttctccag     1380

agccacgaga accaggagat ctaccagaag gccttcgacc tcattgagca ctactttggt     1440

gtagaagacg atgatagcag cctggctccc caagtcgatg aaacgcaaca gcagttcatc     1500

ttccagcagc ctgaggcccc catggagggc ttccagctat aatatctgcc tccagggagg     1560

ggaggggatg ggaagcacca ccagccagcg gaagagcagc cctctggtgg gcgggaaacc     1620

agtgtcccca ccatcagcca ccacacacct ctgctgccct ggagactgtg ctcttgacct     1680

gctccgcccc cttccctgga gggagcaccc tctggacaga cagaaccatc tgaggctcac     1740

ctttgggttt tgtgacaaga aggggacgtg ttgggttttt cttccttaca ctatattttg     1800

gctgcacaca tgtctttaac ccaggagccc aggggtagac aaaggaggac taaggtaatc     1860

aatttgcacc tttttttatt tttatttttt ttcttttttt cttcagtggt gacttccttc     1920

cctttatctt ttttcattct tcccggtcct ctgccctgat ctgtgtaact cttatcttgg     1980

gtacttgagc agacggtata ttccagaggt gggaggtggg aggggaaggg agaaatccaa     2040

aacaaagtgt tcttgctctg acagaatatt aatcttgtac gcttggattg agttatttaa     2100

tttttttttc ttttgcacat ttttcttgta ttaagattgc tcttcccaag agccacaagt     2160

tcctggtttt agtaaaccca gctgcctgca ttgcctggga ctagaggctg gggaggctac     2220

catgaaacaa aggtccctcc ctccctctga ctctttgccc agacctcttt agtttggggg     2280

atcctcctca ctctcctgaa gtgtctcaag tataccagtg ggagtgcagg ggaggagcac     2340

aggccttcag atggggcttc ccacgtgtag ctactgatcc catatttcct actcaccttc     2400

caaatggtgc gacccaactt catttgttta cttgaaaatt ccccctcgag gttgagagaa     2460

cctctgaggt ggctgtattt tctcctaagc ttgagatagg gggctgtggt ccttcctttc     2520

tcctgaggag aaagtccttg ctctggtgac ctgtaagttg cagaggaggg tggagtgaga     2580

gtgtcatgta ttgggatagt cagggatccc tgcctttggc ctttcttctt cttcttcttc     2640

ctcttccata gttggatcat gtatatttta cttctaaagg agagaatgtc aaaaagttct     2700

gtattttttt atattctata tattaggtag gtcaatctta attggtctca agaggaagaa     2760

ctgtctgtca tttcggtaag taggatactg tgaggaagac caaaaagaga tatggatgct     2820

tcctcgctca ggaggcctga gcttggtcct tttcctctct gcttggattc tggaccacca     2880

cctgggacca accttcagct ctggaacctt cataaagcag gtcagcgtgg cctgattgtc     2940

ccaggacctg aagggagcaa ggatggcctc agggcctggt gaagtctgct actctgtcct     3000

tactgctgaa catcctgctt gtatcaggaa actcagaagc agtttgcctt gtcaaattca     3060

atctcaatgg ccattgtcca cataactgat cacccatggc tgcctctcct attatctatt     3120

atcactgaaa cttagtagcc tgcttttttt tttttttttt ttagagctat tgcgtatctt     3180

ccctgtttgg gatccttgta cctggtttgg gttttccctt ccttgtgaca attataatcc     3240

agatgcctct tctttctgtt tgaattacgg tagtgcattg ccttagtggc ttgcctgtgc     3300

ctctgggtgg attacatatg atagtaaagc ccacctgttt ggatgggagt agaggaagtt     3360

ggtgtagacc agctgtggag ctgaaggcac agtctgcccc acccccacct ccccactgtg     3420

gttagtcaga ggcatcctgc tccaagctct gcttttcctt cctctgaaac aatgccattc     3480

ttgcttctat tgctacacat ctccttctgg ctcaggtgaa atccatgccc ttctgcttat     3540

agacctaaag ttcaggtact tattattggc cattgatctt gaatttgccc tctcctagtg     3600

ctgcagtccc acttcaaagc cattttctga ggaggatggt ttaggtctgg caattgtcct     3660

tgaaaaatcc cacccatgtt gtaccacctt ggtgagtcat atgccactca tcagcttggg     3720

aatgatggct gccaactccc aatctcccag gaaggcaggg ggcagaatct ttttttcact     3780

tggcctgcta cctccattaa aaaaccattc tcttacagtt t                         3821


<210> 1848
<211> 886
<212> DNA
<213> Homo sapiens

<400> 1848
ctataaaaat gtgcccggcg gcaaagctgc agaaggggca ccgctgagct gccgagagga       60

agctcgctct gcccggctgc cctcttgtag tccgccggcg aggggcagtt ctcggtgagg      120

aggaagagag cagcggacgg cacagcaccc gcgcgggccc tcccacaaca gctccagctg      180

gcagcatcac ttcccgccaa tttatccaac ttctgccaag gctctgaaat gccaacaacg      240

tcgaggcctg cacttgatgt caagggtggc acctcacctg cgaaggagga tgccaaccaa      300

gagatgagct ccgtggccta ctccaacctt gcggtgaaag atcgcaaagc agtggccatt      360

ctgcactacc ctggggtagc ctcaaatgga accaaggcca gtggggctcc cactagttcc      420

tcgggatctc caataggctc tcctacaacc acccctccca ctaaaccccc atccttcaac      480

ctgcaccccg cccctcactt gctggctagt atgcacctgc agaaacttaa tagccagtat      540

caggggatgg ctgctgccac tccaggccaa cccggggagg caggacccct gcaaaactgg      600

gactttgggg cccaggcggg aggggcagaa tcactctctc cttctgctgg tgcccagagc      660

cctgctatca tcgattcgga cccagtggat gaggaagtgc tgatgtcgct ggtggtggaa      720

ctggggttgg accgagccaa tgagcttccg gagctgtggc tggggcagaa tgagtttgac      780

ttcactgcgg actttccatc tagctgctaa tgccaagtgt ccctaaagat ggaggaataa      840

agccaccaat tctgttgtaa ataaaaataa agttacttac aaagag                     886


<210> 1849
<211> 7378
<212> DNA
<213> Homo sapiens

<400> 1849
ccgtcctaca gatccgccat attgtctact gaaagctgcc gctgaagctg ccgccgttgc       60

ctccgccgcc aagagtgagc gagcggaccc gcgatggaga ccatggcgag cccagggaaa      120

gacaattatc gaatgaagag ctataagaac aatgctctaa accctgaaga aatgagacga      180

agaagagagg aagagggcat tcagctccgg aagcagaagc gagagcaaca actttttaaa      240

cggagaaatg tggagctgat taatgaagaa gctgccatgt tcgatagtct tctcatggac      300

tcttatgtga gctctaccac tggggagagt gtgatcacaa gagagatggt ggagatgctc      360

ttttctgatg attctgacct gcagttagca accacacaga aattccggaa actgctctcc      420

aaagagccta gtcctccaat agatgaagtt atcaacactc caagagtggt ggatcggttc      480

gtggagtttc tgaagaggaa tgagaattgt acattacagt ttgaagctgc ctgggctcta      540

acgaatattg cctctggaac ctctcagcag accaaaattg tcattgaagc aggggctgtc      600

cccattttta tagagctgct taattcagac tttgaggatg ttcaggaaca ggcagtctgg      660

gcactgggaa acatagctgg agatagctct gtttgccgag attacgtctt gaactgttcc      720

atccttaatc ctttgttaac actccttacc aagtccacac gactgacgat gacacggaat      780

gcagtctggg ccctgtcaaa tctctgccga gggaaaaacc cacccccaga gtttgcaaag      840

gtctctcctt gtttgcctgt actgtctcgc ctactcttca gcagcgactc ggacttgctg      900

gcagatgctt gctgggccct ttcttatctg tctgatggcc ccaatgagaa gatccaggca      960

gtcatagact ccggagtctg ccggagattg gtagagctgc tgatgcacaa tgattacaaa     1020

gtggcttctc ctgccctgag agccgtgggt aacatcgtca ctggggatga catccagacc     1080

caggtcattc ttaactgttc agccctacct tgccttctcc acttgttgag cagtcccaag     1140

gagtcaatcc ggaaggaagc ttgctggact atttcaaata ttactgctgg caacagggct     1200

caaatacagg ctgttataga tgcaaatatc ttccctgtgt tgatcgaaat ccttcagaaa     1260

gcagagtttc gtacaaggaa agaggcagcc tgggccatca ccaatgccac atcaggagga     1320

acccctgagc agatcaggta cctggtctca ctgggctgca tcaaacccct atgtgacttg     1380

ctgactgtaa tggattcgaa gattgtgcaa gtggccctca atggactgga gaacatcctg     1440

cggcttggag agcaagaggg caagcgcagt ggctcagggg tcaatcctta ttgtggcctc     1500

atagaggaag cctatggctt ggataaaatt gagtttctcc agagccacga gaaccaggag     1560

atctaccaga aggccttcga cctcattgag cactactttg gtgtagaaga cgatgatagc     1620

agcctggctc cccaagtcga tgaaacgcaa cagcagttca tcttccagca gcctgaggcc     1680

cccatggagg gcttccagct ataatatctg cctccaggga ggggagggga tgggaagcac     1740

caccagccag cggaagagca gccctctggt gggcgggaaa ccagtgtccc caccatcagc     1800

caccacacac ctctgctgcc ctggagactg tgctcttgac ctgctccgcc cccttccctg     1860

gagggagcac cctctggaca gacagaacca tctgaggctc acctttgggt tttgtgacaa     1920

gaaggggacg tgttgggttt ttcttcctta cactatattt tggctgcaca catgtcttta     1980

acccaggagc ccaggggtag acaaaggagg actaaggtaa tcaatttgca ccttttttta     2040

tttttatttt ttttcttttt ttcttcagtg gtgacttcct tccctttatc ttttttcatt     2100

cttcccggtc ctctgccctg atctgtgtaa ctcttatctt gggtacttga gcagacggta     2160

tattccagag gtgggaggtg ggaggggaag ggagaaatcc aaaacaaagt gttcttgctc     2220

tgacagaata ttaatcttgt acgcttggat tgagttattt aatttttttt tcttttgcac     2280

atttttcttg tattaagatt gctcttccca agagccacaa gttcctggtt ttagtaaacc     2340

cagctgcctg cattgcctgg gactagaggc tggggaggct accatgaaac aaaggtccct     2400

ccctccctct gactctttgc ccagacctct ttagtttggg ggatcctcct cactctcctg     2460

aagtgtctca agtataccag tgggagtgca ggggaggagc acaggccttc agatggggct     2520

tcccacgtgt agctactgat cccatatttc ctactcacct tccaaatggt gcgacccaac     2580

ttcatttgtt tacttgaaaa ttccccctcg aggttgagag aacctctgag gtggctgtat     2640

tttctcctaa gcttgagata gggggctgtg gtccttcctt tctcctgagg agaaagtcct     2700

tgctctggtg acctgtaagt tgcagaggag ggtggagtga gagtgtcatg tattgggata     2760

gtcagggatc cctgcctttg gcctttcttc ttcttcttct tcctcttcca tagttggatc     2820

atgtatattt tacttctaaa ggagagaatg tcaaaaagtt ctgtattttt ttatattcta     2880

tatattaggt aggtcaatct taattggtct caagaggaag aactgtctgt catttcggta     2940

agtaggatac tgtgaggaag accaaaaaga gatatggatg cttcctcgct caggaggcct     3000

gagcttggtc cttttcctct ctgcttggat tctggaccac cacctgggac caaccttcag     3060

ctctggaacc ttcataaagc aggtcagcgt ggcctgattg tcccaggacc tgaagggagc     3120

aaggatggcc tcagggcctg gtgaagtctg ctactctgtc cttactgctg aacatcctgc     3180

ttgtatcagg aaactcagaa gcagtttgcc ttgtcaaatt caatctcaat ggccattgtc     3240

cacataactg atcacccatg gctgcctctc ctattatcta ttatcactga aacttagtag     3300

cctgcttttt tttttttttt ttttagagct attgcgtatc ttccctgttt gggatccttg     3360

tacctggttt gggttttccc ttccttgtga caattataat ccagatgcct cttctttctg     3420

tttgaattac ggtagtgcat tgccttagtg gcttgcctgt gcctctgggt ggattacata     3480

tgatagtaaa gcccacctgt ttggatggga gtagaggaag ttggtgtaga ccagctgtgg     3540

agctgaaggc acagtctgcc ccacccccac ctccccactg tggttagtca gaggcatcct     3600

gctccaagct ctgcttttcc ttcctctgaa acaatgccat tcttgcttct attgctacac     3660

atctccttct ggctcaggtg aaatccatgc ccttctgctt atagacctaa agttcaggta     3720

cttattattg gccattgatc ttgaatttgc cctctcctag tgctgcagtc ccacttcaaa     3780

gccattttct gaggaggatg gtttaggtct ggcaattgtc cttgaaaaat cccacccatg     3840

ttgtaccacc ttggtgagtc atatgccact catcagcttg ggaatgatgg ctgccaactc     3900

ccaatctccc aggaaggcag ggggcagaat ctttttttca cttggcctgc tacctccatt     3960

aaaaaaccat tctcttacag tttaaaaaaa aaaaaaaaaa aaaagccttc ccctacccaa     4020

cctccgccca ttgttctctt ccaaagggca atttagtagg atctactttg tacatctcaa     4080

gtaagagtta agtccctgat acagggacca gtttcttagt gtaagacata cacatcctgc     4140

ttgtccagct gttcctccaa aatctacttt ggcttcagct ccgggtcctg taccagatgg     4200

aaaatgtttt tggtgatctg gctgctgctt aaagccagtt ttccctaaga actccaaagg     4260

ctaaagtcta ctaggggcag agtgtgagga tagatttcta atcagagaaa agtggcctcc     4320

aggagctttc atttatgtct tctccagacc aggttttcct gttatcttcc tttaatcccc     4380

tttcaaccaa caggtgaagt tcttccagcc cacagaggta gtaatatcat cttttctatc     4440

tcctcctctc ctttggccat gtaatgaagc aaaatattat ttatttagcc caggcttgag     4500

agccactgtt tgtggacagt cttcatctag attccatacc ctggcctagg cgaggtaagg     4560

ctctctggtt attgccagga tggagcccct ctaccccagt ctgctgtagg gaatacccta     4620

attagttgag gcatgctttt ggaatcctgg catgttggca tatggctggt ctatcctttt     4680

taagatctct ggttgggggt atctggatat ggattaggag ggacaaggag cctttttctt     4740

ggctaatgtt ttccaatact tttttgaatg gtgccagccc ctccaggcat cccaccccca     4800

aatcatcatc tttagtacta acagggtgtc tggtcttaga agcctccctt cagatcccag     4860

ctgaccctgg tgactgcctg gccttgatgt tggctgcagc cttctgatag aaccacatgg     4920

attccaccca cagctggcca ggcttgttac atgggtcagg gaatacaaat ggcccccccc     4980

cagggagcag gtgttggcct cagttttcag ggacccttgg tgttgctcct tacctagagc     5040

ccattaatct accccatcaa ctctctgcca tgaaagccat cttccaggag ccctgttttt     5100

tggagctgaa ctgcacagat tatagctgct attgtactta aataagggag aggaaaagaa     5160

ggttctcagg cacagacttt ctatttttct caagccaaac cagtttaaaa tgtctagcag     5220

aatgaactgt atttccattt cttcatgtct acctgccttc cccccacacc ctaaagttgt     5280

acttgtttct agcaaactag aaggaaaaga taggaaagcc tggcactact aacctcacct     5340

ctcatacacc tctttgaagg ccccagctct tttgttcagg cctctcttct cccctagact     5400

cactcagctt ggtatccatc atcttgagca ttcttcagta gattcatcta gggttcagat     5460

tccagactct cagctgaaga cagggagcca atttccccca ggtccctgca ggtaatccag     5520

ggaccccata gggagaacag gctgactggg gcattaggaa tgtttgtacc tctctgcttc     5580

cctggcagcc tggggaaggg tgcagggctc agtgcgctaa accatggtaa acatcttcaa     5640

tagaactacc ctagaattta gtgagtgtga gactgagata ttgctcagaa taaatttatt     5700

ccatagccat ttaggattgc atgttctgga ccaaccttgt ccagtatgtt ttctgtttga     5760

gctttttcat tcttttgtta agccaacaag ttgagaattt ggccctgctg ggatccatgt     5820

agtgggcact agctgctctt tggccaaggc cttcataaat gattcagtct ctcattatct     5880

gtcctctagc cccacaccct gatttagacc gtggcaaagg aagaacttga ggtcaagacc     5940

aaccaaatct gtgaattaaa gctgttattt ttttctctgc aagggcgctt tgcttcaggt     6000

ctgggctatg tgcagaacct aagcaggctg tgagagttag aagaggcagt attacatgtt     6060

aggcccagaa caccatggga aaaggtttat gtagtgtatc ttagtggcct gcctagctgc     6120

ctctgggcca ggctgacttc tgatgtccac attagctcgt acctgaaccc tgttgctgaa     6180

tgccagccct gttctcctgt aactattata tacgccatgg cctggggggc attgaaggaa     6240

gtaagctctc agagatccta acactggctg ggaacctctg actcagagca tgtctttaaa     6300

gagtccacat ctggccaggc gcggtggcac atgcctgtaa tcccagcact ttgggaggcc     6360

gaggcgggtg gatcacgagg tcaggagttt gagaccagcc tggcaacata gtgaaacccc     6420

atctctaata aaaatacaaa aaattagctg ggcgtggtgg caggcgcctg taatcccagc     6480

tacttgggag gctgagacag gagaatcact tgaacccagg aggcggaggt tgcagtgagc     6540

caagatcatg ccactgcact ccagcttggg tgacagtgcg agactccatc tcaaaaaaaa     6600

aaaaaaaaaa aaaatccaca tcttcagctg ggcgcggtgg ctcatgcctg taatcctagc     6660

actttgggag gctgaggcgg gcagatcact tgaggttagg ggttcaaaac cagcctgacc     6720

aacatagtaa aaccccgtcc ctacaaaaat aaaaaaataa aaaaaataag ccaggtgtgg     6780

tggtgggcac ctgtgatctc agctacgtgg gaggctgagg caggagaatc tcttgaacct     6840

aggaggcaga ggttgcagtg agccaagatt gtgccagcct gggcgacagg gtgaggctct     6900

tgtctcaaaa aaaaaagtcc acatcttcat gaaccctcag actctggagt tgggtgtcgg     6960

cttttttagc cagcttttgt gggaattgcc tttgacctat taaagaagga aagtgggtaa     7020

tggagtccca gccactcaag agactggata tcccccgaga atggcttggg ttaccagcta     7080

tggacccttg gaagatgaat ctaatccttc tcactggttt ttctttgcaa attcatttgc     7140

ttttattttt ctaataacaa taaactctat tttccatgtt ctcagggccc ctgggtagac     7200

agacacagct tgatttcaga gcagacatag gcgaagaaaa catggcattg agtgtgctga     7260

gtccagacaa atgttattta tatacacatc caaatttgaa gagaaaatgt atttctttag     7320

gtttcaaaca ctgtaataga tataaagcaa aaataaaaac ctgttgcaaa gttctaaa       7378


<210> 1850
<211> 3230
<212> DNA
<213> Homo sapiens

<400> 1850
ggggtcctgg cgagaagcga gccggcggcc tgaggaggcg actgactgag cagcgcaccc       60

ggggagcaag gaggcgcggt gaactgagcg gcccctgagc tgacagatac actgcgcagc      120

tggaacggcg agcgagccga cgggcgagtg aggggcgcag ccatgatcac ctcggccgct      180

ggaattattt ctcttctgga tgaagatgaa ccacagctta aggaatttgc actacacaaa      240

ttgaatgcag ttgttaatga cttctgggca gaaatttccg agtccgtaga caaaatagag      300

gttttatacg aagatgaagg tttccggagt cggcagtttg cagccttagt ggcatctaaa      360

gtattttatc acctgggggc ttttgaggag tctctgaatt atgctcttgg agcaggggac      420

ctcttcaatg tcaatgataa ctctgaatat gtggaaacta ttatagcaaa atgcattgat      480

cactacacca aacaatgtgt ggaaaatgca gatttgcctg aaggagaaaa aaaaccaatt      540

gaccagagat tggaaggcat cgtaaataaa atgttccagc gatgtctaga tgatcacaag      600

tataaacagg ctattggcat tgctctggag acacgaagac tggacgtctt tgaaaagacc      660

atactggagt cgaatgatgt cccaggaatg ttagcttata gccttaagct ctgcatgtct      720

ttaatgcaga ataaacagtt tcggaataaa gtactaagag ttctagttaa aatctacatg      780

aacttggaga aacctgattt catcaatgtt tgtcagtgct taattttctt agatgatcct      840

caggctgtga gtgatatctt agagaaactg gtaaaggaag acaacctcct gatggcatat      900

cagatttgtt ttgatttgta tgaaagtgct agccagcagt ttttgtcatc tgtaatccag      960

aatcttcgaa ctgttggcac ccctattgct tctgtgcctg gatccactaa tacgggtact     1020

gttccgggat cagagaaaga cagtgactcg atggaaacag aagaaaagac aagcagtgca     1080

tttgtaggaa agacaccaga agccagtcca gagcctaagg accagacttt gaaaatgatt     1140

aaaattttaa gtggtgaaat ggctattgag ttacatctgc agttcttaat acgaaacaat     1200

aatacagacc tcatgattct aaaaaacaca aaggatgcag tacggaattc tgtatgtcat     1260

actgcaaccg ttatagcaaa ctcttttatg cactgtggga caaccagtga ccagtttctt     1320

agagataatt tggaatggtt agccagagcc actaactggg caaaatttac tgctacagcc     1380

agtttgggtg taattcataa gggtcatgaa aaagaagcat tacagttaat ggcaacatac     1440

cttcccaagg atacttctcc aggatcagcc tatcaggaag gtggaggtct ctatgcacta     1500

ggtcttattc atgccaatca tggtggtgat ataattgact atctgcttaa tcagcttaag     1560

aacgccagca atgatatcgt tagacacggt ggcagtctgg gccttggttt ggcagccatg     1620

ggaactgcac gtcaagatgt ttatgatttg ctaaaaacaa acctttatca ggatgatgca     1680

gtaacagggg aagcagctgg cctggcccta ggtttggtta tgttgggctc taaaaatgct     1740

caggctattg aggacatggt tggttatgca caagaaactc aacatgagaa gattctgcgt     1800

ggtcttgcag ttggcatagc tttagtaatg tatgggagga tggaagaggc tgatgctctc     1860

attgaatctc tctgtcgtga caaggaccca attcttcgaa ggtctggaat gtatactgta     1920

gccatggctt attgtggctc tggtaacaac aaagcaattc gacgcctgct acatgttgct     1980

gtaagtgatg ttaatgatga tgtcaggagg gcagcagtag aatcacttgg gttcattcta     2040

ttcagaaccc ctgaacagtg cccaagtgtt gtctctttgt tgtcagagag ttacaaccct     2100

catgtgcgct acggagctgc aatggccttg gggatatgct gtgctggtac aggaaacaag     2160

gaagccatta atttgctaga accaatgaca aacgaccccg tgaactacgt gaggcaaggg     2220

gcactcatag cttcagctct catcatgatc cagcagactg aaatcacttg tccaaaggtg     2280

aatcagttca gacagctgta ttccaaagtc atcaatgata agcatgatga tgtcatggcc     2340

aagtttggcg ctattctggc ccagggcata ctggatgcag gtggtcataa tgtcacaatc     2400

tccttgcagt ccaggactgg gcatactcat atgccttctg tggttggcgt ccttgtattt     2460

acccagtttt ggttctggtt tcctctttca cacttcctgt cattggctta tacccctacc     2520

tgtgtcattg gccttaacaa ggacttaaag gtttctactg ctgtattatc tataactgcc     2580

aaggctaaaa agaaggaaaa agaaaaggaa aaaaaggagg aggagaaaat ggaagtggat     2640

gaggcagaga aaaaggagga aaaagagaag aaaaaagaac ctgagccaaa cttccagtta     2700

ttggataacc cagcccgagt tatgcctgcc cagcttaagg tcctaaccat gccggagacc     2760

tgtagatacc agcctttcaa accactctct attggaggca tcatcattct gaaggatacc     2820

agtgaagaca ttgaggagct ggtggaacct gtggcagcac atggcccaaa aatcgaggag     2880

gaggaacaag agccagaacc cccagaacca tttgagtata ttgatgatta agggccagag     2940

gatctcactt gcttatctga agaagattgt ccaggctcat attgggaatg cttatgagga     3000

aattcatgcc gagacctgct attcaatgca tgtatcgttg cctctgcact gacctgaaga     3060

accctgtctc caagtctttg gttgaagaga agatatatga ctgttgagtg tgctctttca     3120

cagaacttgg ttttcaaata aatataagat ctccagatgg acaagacatt tgtttttcag     3180

cctgggtttt taataaatgt atctaatcct ccccacacca tgaaatgcct                3230


<210> 1851
<211> 2003
<212> DNA
<213> Homo sapiens

<400> 1851
aattagttgc taaagatgcc agagtgtgtg cacgtacagg ctttttcttt cccctccccc       60

tttcttcctt ttcccaagcc ccctcttctc cctgtttccc ctcctactcc tttatctcct      120

ccctccgtgt cttagttctg cagtacgcgg gttgaagcac attcctgctt tgcaaggctt      180

tctgctaagg atgtattgtg gcttttgttt ggattgcagc atgcagaatt acaggagtct      240

ccccaggaca gtgctatcac ccgggatatt aaccgaacat tcccagccca tgactacttt      300

aaggacacag gaggagatgg acaagattcc ttatataaaa tatgcaaggc ttattctgtg      360

tatgatgaag agattggtta ttgccagggc cagtcatttc ttgctgctgt gctccttctc      420

catatgcctg aagaacaggc attcagtgtt ctggtcaaga tcatgtttga ctatgggctc      480

agggaacttt tcaagcaaaa cttcgaagat ttgcattgca aattttacca gttggagcgc      540

ctcatgcagg aatacattcc tgacctgtac aaccacttcc tggatataag ccttgaagca      600

cacatgtatg cctcccagtg gtttcttact cttttcactg caaaattccc tctctacatg      660

gtcttccata tcatcgacct gcttttatgt gagggaataa gtgttatttt taatgtcgcc      720

cttggattat taaagacttc gaaagatgac ctgctgttga cagactttga aggtgccttg      780

aagttcttta gggttcagct tcctaagaga taccgctcag aagaaaatgc aaaaaaacta      840

atggaattag cctgcaacat gaagattagt cagaagaagt tgaaaaaata cgagaaagaa      900

tatcacacca tgagggaaca gcaggcccag caagaagacc ccatcgagcg atttgagcgg      960

gagaataggc gtctacaaga agctaacatg aggttggaac aggaaaacga tgacttagcc     1020

catgagctgg tgaccagcaa gattgcacta cggaaggacc tggataacgc tgaggaaaag     1080

gcagatgctc tgaataagga gctgctgatg accaaacaga agttgattga tgcagaagaa     1140

gagaaaagac ggctggaaga agagtctgct cagttaaaag aaatgtgccg tcgggaactc     1200

gacaaggcag aatctgagat taaaaaaaac agttctatca ttggtgacta taagcagatt     1260

tgttctcagt tgagtgaaag attggagaag cagcagacag ccaataaggt ggaaattgag     1320

aaaattcggc aaaaagtgga tgactgtgag cggtgccggg aatttttcaa caaagaaggg     1380

cgtgtaaaag gcataagctc aaccaaggag gttttagatg aggacacgga tgaagagaaa     1440

gagacgctca agaaccagct gagagaaatg gagctagaac tggcacagac caaactccag     1500

ctggtggagg ccgagtgtaa gatacaggac ttggaacacc atttagggct tgccctcaat     1560

gaggtgcagg cagccaagaa gacgtggttt aaccgaacac tgagctccat aaagacagca     1620

accggggttc aagggaaaga gacttgctga gagcagctgc cgcctcccga caccttcaga     1680

aaacacgaca ccttttgttg ccttctttgg ccagatgtgt gattctgtga cttgtcccag     1740

gaccagaatg tacctaagtc agatccatag acgcatgttg gtaggtcact ggaccagagc     1800

ttgtgaagca ggcaacctct ggggtaagac tactgatact aacaggcctg ctagctcagc     1860

cgacgctctg gacactctag aaatcactcc tcagtgtgac ctcccaggcc tcttccccgt     1920

gtacgtcaac acctcaccca gcctaaaggc tgagtttaca tgatcagagt taggggatcc     1980

ttcagtctgt tgattttttt tct                                             2003


<210> 1852
<211> 4997
<212> DNA
<213> Homo sapiens

<400> 1852
ggggacaggg cggtttggga ggcccaggcg gcggagcctc cgggacggcg agcggcgggc       60

ggcggaggag gagacggcag gtcgggcatt aaaaaatatt taatcattca tgtgttgaga      120

ctcattcttg agttatggat gacaaggctt ctgttggaaa aatcagtgtc tcttcagact      180

cagtatctac tcttaatagt gaagattttg tcttggtttc caggcaagga gatgagacac      240

catctacaaa taatggaagt gatgatgaga aaacaggact caagattgta gggaatggaa      300

gtgaacagca gctgcaaaaa gagctagcag atgtactgat ggatcctcca atggacgacc      360

agccagggga aaaggagctt gtgaaaaggt cacaactgga tggtgaagga gatgggcctc      420

tttctaatca gctctccgct tcatccacca ttaaccctgt gccattagta gggctccaaa      480

aaccagagat gagcctacca gtgaaacctg gacaaggaga ttctgaagct tcaagtcctt      540

tcacaccagt ggccgatgag gacagcgtag ttttcagtaa actgacttac ttaggctgtg      600

cctcggtaaa tgctcccagg agtgaagtgg aagccttaag gatgatgtcc atcttaagaa      660

gccagtgtca gatttcacta gatgttaccc tttcagtgcc gaatgtgtct gaaggaattg      720

tgagactctt agatcctcag acaaacactg aaatagcaaa ctaccctatc tacaaaatcc      780

tcttctgtgt cagagggcat gatggaactc ctgagagtga ctgttttgct ttcactgaaa      840

gtcattacaa tgcagagctc ttcagaatac acgtcttccg gtgtgaaata caagaagctg      900

taagccggat actttacagt tttgccactg ccttccgccg ttctgccaag cagaccccac      960

tttcagccac tgctgcaccc cagactcctg acagtgacat ctttaccttc tctgtgtctt     1020

tagaaataaa agaagatgat ggtaaaggtt attttagtgc agttcccaaa gataaggaca     1080

gacagtgctt taaactacgc caaggaattg ataagaagat tgtcatctat gtgcagcaaa     1140

caactaataa agaacttgcc attgaaaggt gttttggtct tctccttagt ccaggaaaag     1200

atgtacgaaa tagtgacatg cacttattag atttggaatc tatgggcaaa agttcagatg     1260

gaaagtcgta tgttattacg gggagctgga atccaaaatc cccacatttt caagttgtaa     1320

atgaagaaac tcctaaagat aaagtcctgt ttatgaccac agctgtagat ttggtaataa     1380

cagaagtaca ggagcctgtt cgatttctcc tggagacaaa agtccgcgtt tgctcaccta     1440

atgaaagatt attctggccc ttcagcaaac gtagtactac tgaaaatttc tttttgaaac     1500

taaaacagat aaagcaaagg gagagaaaga ataatactga cactttatat gaagttgtat     1560

gcttggaaag tgaatcagaa agagagagga ggaaaactac agccagtcct tcagttcgcc     1620

tgccacagtc tggatcgcaa agttcagtga taccttctcc tccagaagat gatgaagagg     1680

aagataatga tgaacctctc ctgagtggat ctggtgatgt atccaaagaa tgtgcagaaa     1740

aaattcttga aacatgggga gaactgttgt caaaatggca tctcaacttg aatgtgagac     1800

cgaagcagtt gtcatcctta gtaagaaacg gtgtccctga agctcttcga ggagaagtct     1860

ggcagctgct agcaggctgt cataacaatg accacctggt agagaaatac cgcattctta     1920

tcacaaagga gtctccccag gacagtgcta tcacccggga tattaaccga acattcccag     1980

cccatgacta ctttaaggac acaggaggag atggacaaga ttccttatat aaaatatgca     2040

aggcttattc tgtgtatgat gaagagattg gttattgcca gggccagtca tttcttgctg     2100

ctgtgctcct tctccatatg cctgaagaac aggcattcag tgttctggtc aagatcatgt     2160

ttgactatgg gctcagggaa cttttcaagc aaaacttcga agatttgcat tgcaaatttt     2220

accagttgga gcgcctcatg caggaataca ttcctgacct gtacaaccac ttcctggata     2280

taagccttga agcacacatg tatgcctccc agtggtttct tactcttttc actgcaaaat     2340

tccctctcta catggtcttc catatcatcg acctgctttt atgtgaggga ataagtgtta     2400

tttttaatgt cgcccttgga ttattaaaga cttcgaaaga tgacctgctg ttgacagact     2460

ttgaaggtgc cttgaagttc tttagggttc agcttcctaa gagataccgc tcagaagaaa     2520

atgcaaaaaa actaatggaa ttagcctgca acatgaagat tagtcagaag aagttgaaaa     2580

aatacgagaa agaatatcac accatgaggg aacagcaggc ccagcaagaa gaccccatcg     2640

agcgatttga gcgggagaat aggcgtctac aagaagctaa catgaggttg gaacaggaaa     2700

acgatgactt agcccatgag ctggtgacca gcaagattgc actacggaag gacctggata     2760

acgctgagga aaaggcagat gctctgaata aggagctgct gatgaccaaa cagaagttga     2820

ttgatgcaga agaagagaaa agacggctgg aagaagagtc tgctcagtta aaagaaatgt     2880

gccgtcggga actcgacaag gcagaatctg agattaaaaa aaacagttct atcattggtg     2940

actataagca gatttgttct cagttgagtg aaagattgga gaagcagcag acagccaata     3000

aggtggaaat tgagaaaatt cggcaaaaag tggatgactg tgagcggtgc cgggaatttt     3060

tcaacaaaga agggcgtgta aaaggcataa gctcaaccaa ggaggtttta gatgaggaca     3120

cggatgaaga gaaagagacg ctcaagaacc agctgagaga aatggagcta gaactggcac     3180

agaccaaact ccagctggtg gaggccgagt gtaagataca ggacttggaa caccatttag     3240

ggcttgccct caatgaggtg caggcagcca agaagacgtg gtttaaccga acactgagct     3300

ccataaagac agcaaccggg gttcaaggga aagagacttg ctgagagcag ctgccgcctc     3360

ccgacacctt cagaaaacac gacacctttt gttgccttct ttggccagat gtgtgattct     3420

gtgacttgtc ccaggaccag aatgtaccta agtcagatcc atagacgcat gttggtaggt     3480

cactggacca gagcttgtga agcaggcaac ctctggggta agactactga tactaacagg     3540

cctgctagct cagccgacgc tctggacact ctagaaatca ctcctcagtg tgacctccca     3600

ggcctcttcc ccgtgtacgt caacacctca cccagcctaa aggctgagtt tacatgatca     3660

gagttagggg atccttcagt ctgttgattt tttttctaaa cctttttttt ttaatataca     3720

tatatatata tatatatata tatatatata tatatatata tatatatagt gggggtgggg     3780

caagggatca gaaattcaaa taattctttt ctgcttcaat gccagcagaa ggtcccccag     3840

gtagacatgg agaagcactt tgttttaaat aggagggttt catagttgca tctgaagcca     3900

cctggttctg ttaaactgta tggtgcaggt tttgggtttg gcattattca tgtttctgat     3960

caattctatg caactctcat agttcctgtt actttttagc attagctgcc aaatgacttc     4020

aaaaggctgg ggtgggtgac ttgactgtga gactggatta taacatggac aaatcttatt     4080

ttgcttaatg tgtttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tatatatata     4140

tataaatatc tttcccaata tgccccgttg acagtgttta aattccagac taggactgct     4200

gatctgcaca atttaattat gtggttattc gagcacttaa tttcactcaa ggttcattgg     4260

gctctgctct cctccctgcc attacgggag ctgtggacag agctccctca cttcaagatt     4320

cctagtgttt ttgcacaaca ggttgtccaa gtgagaaaga ctgagttgcg tgtctgtaaa     4380

tgtctgcgca gggtgcacat gctgcgaggt ctccatcctc cgggcctgtc cctcccagat     4440

gggctgggcc tttgggccct cctcagagta tgcctgggta caaacctcac tgttcagatg     4500

ggctgtaagt tctcacttca aagctatgga atggatttta gcacctttaa aaaaaaaaaa     4560

aactttgact tttaatttat atagtgatat gctgacaggc tgacacgcag atggttttgt     4620

cctcttttct gcgttcagtg ttgaggcggc tgcttacaag aggcactggt tttgtatata     4680

aagacactcg ggttgttttg tagctctttt tcttattggc tgtactaacg cttgctgagg     4740

ttatctgtaa taagggaggt aacaagtggc aaccccctcc ccaccaacca tcccctttgc     4800

tgctttctgt gtctttcttg ttcagttacc aaaatagctg taagcctatc taatgctagg     4860

tgtgtggaca ttgtgctaag gtagtttcag tgtgtcaact ttatgaattg aaatataaac     4920

cagtaaaatt gtattactgt ttcttttgtt ggttttattt taacagcata ttgattaaat     4980

attttggtac aaacaaa                                                    4997


<210> 1853
<211> 2980
<212> DNA
<213> Homo sapiens

<400> 1853
taaaggtgta gctagcttga accagagtgc actgagccgt ccaatgcaaa ggaaactggt       60

gacacttgta aactgtcaac tggtggagga agaaggtcgt gtaagagcca tgcgagcagc      120

tcgttccctt ggagaaagaa ctgtaacaga actgatatta cagcaccaga accctcagca      180

gttgtctgcc aatctatggg ccgctgtcag ggctcgagga tgccagtttt tagggccagc      240

tatgcaagaa gaggccttga agctggtgtt actggcatta gaagatggtt ctgccctctc      300

aaggaaagtt ctggtacttt ttgttgtgca gagactagaa ccaagatttc ctcaggcatc      360

aaaaacaagt attggtcatg ttgtgcaact actgtatcga gcttcttgtt ttaaggttac      420

caaaagagat gaagactctt ccctaatgca gctgaaggag gaatttcgga gttatgaagc      480

attacgcaga gaacatgatg cccaaattgt tcatattgcc atggaagcag gactccgtat      540

ttcacctgaa cagtggtcct ctcttttgta tggtgatttg gctcataaat cacacatgca      600

gtctatcatt gataagctac agtctccaga gtcatttgca aagagtgtcc aggaattgac      660

aattgttttg caacgaacag gtgacccagc taacttaaat agactgaggc ctcatttaga      720

gcttcttgca aacatagacc ctaatccaga cgctgtttca ccaacttggg agcagctgga      780

aaatgcaatg gtagctgtta aaacagtagt tcatggcctt gtggacttca tacaaaatta      840

tagtagaaaa ggccatgaga cccctcagcc tcagccaaac agcaaataca agactagcat      900

gtgccgagat ttgcgacagc aagggggttg tccacgagga acaaattgta catttgccca      960

ttctcaggaa gagcttgaaa agtatcgatt aaggaacaaa aagatcaatg ccactgtaag     1020

aacgtttcct cttctaaata aagttggtgt aaacaacact gtcacaacca cagccggaaa     1080

tgtcatttct gtcataggaa gtactgaaac aacagggaaa attgttccaa gtacaaacgg     1140

aatttcaaat gcagaaaaca gtgtttccca gctaatctca cgtagtactg acagtacctt     1200

aagagctctg gagaccgtga agaaagtggg aaaggttggc gctaatggtc agaatgctgc     1260

tgggccctct gcagattctg taactgaaaa taaaattggt tctccaccca agactcctgt     1320

aagtaatgta gcagctacct cagctgggcc ctctaatgtt ggaacagagc tgaattctgt     1380

gcctcaaaaa tccagcccat ttctaactag agtaccagta tatcctccgc attctgaaaa     1440

cattcagtat tttcaagatc caaggactca gatacccttt gaagtcccac agtacccaca     1500

gacaggatac tatccaccac ctccaacggt accagctggt gtggctccct gtgttcctcg     1560

ctttgtgagg tccaataacg ttccagagtc ctccctccca cctgcttcca tgccatatgc     1620

cgatcattac agtacatttt cccctcgaga tcgaatgaat tcttctcctt accagcctcc     1680

tcctccgcag ccgtatggac cagttcctcc agtaccttct ggaatgtatg ctcctgtgta     1740

cgacagcagg cgcatctggc gcccacctat gtaccaacga gatgacatta ttagaagcaa     1800

ttctttacct ccaatggatg tgatgcactc atctgtctat cagacatctt tgcgggaaag     1860

atataactca ttagatggat attattcggt ggcttgtcag ccaccaagtg agccaaggac     1920

aactgtgcct ttaccaaggg aaccttgtgg tcatttgaag accagttgcg aggagcagat     1980

aagaagaaag ccagatcagt gggcacagta ccacactcag aaagcacctc ttgtctcttc     2040

aactcttcct gtggcaacac agtcaccaac accaccttct cctctgttca gtgtagactt     2100

tcgtgcggat ttctcagaga gtgtgagtgg tacaaaattt gaagaagatc atctttccca     2160

ttattctccc tggtcttgtg gcaccatagg ctcctgtata aatgccattg attcagagcc     2220

caaagatgtc attgctaatt caaatgctgt gttaatggac ctggacagtg gtgatgttaa     2280

gagaagagta catttatttg aaacccagag aaggacaaaa gaagaagatc caataattcc     2340

ctttagtgat ggacccatca tctcaaaatg gggtgcgatt tccagatctt cccgtacagg     2400

ttaccatacc acagatcctg tccaggccac tgcttcccaa ggaagtgcga ctaagcccat     2460

cagtgtatca gattatgtcc cttatgtcaa tgctgttgat tcaaggtgga gttcatatgg     2520

caacgaggcc acatcatcag cacactatgt tgaaagggac agattcattg ttactgattt     2580

atctggtcat agaaagcatt ccagtactgg ggaccttttg agccttgaac ttcagcaggc     2640

caagagcaac tcattacttc ttcagagaga ggccaatgct ttggccatgc aacagaagtg     2700

gaattccctg gatgaaggcc gtcaccttac cttaaacctt ttaagcaagg aaattgaact     2760

aagaaatgga gaggtaaaga aactgaacct ttcggcttca tgcttaatgt atttgttttc     2820

tgctgctgca tcttggttat accattactg agtgcatttt ggtgtgccta tctctgatgg     2880

atgattgatt gcttttaaaa cttataacag aaataaaatt gtaatcccag atttcttaaa     2940

taattcttta actagatcat cgggattttt gtttttttga                           2980


<210> 1854
<211> 1678
<212> DNA
<213> Homo sapiens

<400> 1854
gtcgcggcct tcgccgccgc caacggggct gtccctgtag ctcccgatgg agtttgaggt       60

cgtgaaacct ccgccgagct ctgccccggc gagacgaggc gcctccgtcg ccaagccgcg      120

ccgtcgcggg gctcccggga gcggccctta gcgaccccgc ccgggccccc tcagcttaca      180

aaacactaca cagcaaaata atgatctgct agactgctaa cccgagcatc cagcttccac      240

aatgcctgtg caggcagctc aatggacaga atttctgtcc tgtccaatct gctataatga      300

atttgatgag aatgtgcaca aacccatcag tttaggttgt tcacacactg tttgcaagac      360

ctgcttgaat aaacttcatc gaaaagcttg tccttttgac cagactgcca tcaacacaga      420

tattgatgta cttcctgtca acttcgcact tctccagtta gttggagccc aggtaccaga      480

tcatcagtca attaagttaa gtaatctagg tgagaataaa cactatgagg ttgcaaagaa      540

atgcgttgag gatttggcac tctacttaaa accactaagt ggaggtaaag gtgtagctag      600

cttgaaccag agtgcactga gccgtccaat gcaaaggaaa ctggtgacac ttgtaaactg      660

tcaactggtg gaggaagaag gtcgtgtaag agccatgcga gcagctcgtt cccttggaga      720

aagaactgta acagaactga tattacagca ccagaaccct cagcagttgt ctgccaatct      780

atgggccgct gtcagggctc gaggatgcca gtttttaggg ccagctatgc aagaagaggc      840

cttgaagctg gtgttactgg cattagaaga tggttctgcc ctctcaagga aagttctggt      900

actttttgtt gtgcagagac tagaaccaag atttcctcag gcatcaaaaa caagtattgg      960

tcatgttgtg caactactgt atcgagcttc ttgttttaag gttaccaaaa gagatgaaga     1020

ctcttcccta atgcagctga aggaggaatt tcggagttat gaagcattac gcagagaaca     1080

tgatgcccaa attgttcata ttgccatgga agcaggactc cgtatttcac ctgaacagtg     1140

gtcctctctt ttgtatggtg atttggctca taaatcacac atgcagtcta tcattgataa     1200

gctacagtct ccagagtcat ttgcaaagag tgtccaggaa ttgacaattg ttttgcaacg     1260

aacaggtgac ccagctaact taaatagact gaggcctcat ttagagcttc ttgcaaacat     1320

agaccctaat ccagacgctg tttcaccaac ttgggagcag ctggaaaatg caatggtagc     1380

tgttaaaaca gtagttcatg gccttgtgga cttcatacaa aattatagta gaaaaggcca     1440

tgagacccct cagcctcagc caaacagcaa atacaagact agcatgtgcc gagatttgcg     1500

acagcaaggg ggttgtccac gaggaacaaa ttgtacattt gcccattctc aggaagagct     1560

tgaaaagtat cgattaagga acaaaaagat caatgccact gaagtactga aacaacaggg     1620

aaaattgttc caagtacaaa cggaatttca aatgcagaaa acagtgtttc ccagctaa       1678


<210> 1855
<211> 9248
<212> DNA
<213> Homo sapiens

<400> 1855
agccaagtct tgtcagagat ttcctctttc aggtggcaaa gctgttttct tcacacttga       60

gtctctacaa tattgtttgg atcagtagtt tccaaagttc attaactcct ggccatactt      120

tattatgttt tggggtactg gttatccaag ggaaacactt ttttaaacaa caaaacaaaa      180

aaaccgccca gcagtccaaa gtaatttgtg ttcctaaaaa tggaatatgg aaagttaatt      240

tgcttgtttg atgtggtcgt tgagaaaaat acataaaagc tttgatgttt attatgtgag      300

caaccaatat aaatacagtt tagttgaaag gaacactatt aaggtattgt ttccaggcag      360

aatttcagaa atgtaattaa ttcagcaaat aggtttttta aaaaagacat ccaaaggtta      420

taaaattatt tagaagtatt ttaggtctga agctgtaata gttgacttaa gcaattaact      480

cttcaaaggt gaatgatgaa tatgtggtta attcatactt ttgtccattt ctagcttaca      540

aaacactaca cagcaaaata atgatctgct agactgctaa cccgagcatc cagcttccac      600

aatgcctgtg caggcagctc aatggacaga atttctgtcc tgtccaatct gctataatga      660

atttgatgag aatgtgcaca aacccatcag tttaggttgt tcacacactg tttgcaagac      720

ctgcttgaat aaacttcatc gaaaagcttg tccttttgac cagactgcca tcaacacaga      780

tattgatgta cttcctgtca acttcgcact tctccagtta gttggagccc aggtaccaga      840

tcatcagtca attaagttaa gtaatctagg tgagaataaa cactatgagg ttgcaaagaa      900

atgcgttgag gatttggcac tctacttaaa accactaagt ggaggtaaag gtgtagctag      960

cttgaaccag agtgcactga gccgtccaat gcaaaggaaa ctggtgacac ttgtaaactg     1020

tcaactggtg gaggaagaag gtcgtgtaag agccatgcga gcagctcgtt cccttggaga     1080

aagaactgta acagaactga tattacagca ccagaaccct cagcagttgt ctgccaatct     1140

atgggccgct gtcagggctc gaggatgcca gtttttaggg ccagctatgc aagaagaggc     1200

cttgaagctg gtgttactgg cattagaaga tggttctgcc ctctcaagga aagttctggt     1260

actttttgtt gtgcagagac tagaaccaag atttcctcag gcatcaaaaa caagtattgg     1320

tcatgttgtg caactactgt atcgagcttc ttgttttaag gttaccaaaa gagatgaaga     1380

ctcttcccta atgcagctga aggaggaatt tcggagttat gaagcattac gcagagaaca     1440

tgatgcccaa attgttcata ttgccatgga agcaggactc cgtatttcac ctgaacagtg     1500

gtcctctctt ttgtatggtg atttggctca taaatcacac atgcagtcta tcattgataa     1560

gctacagtct ccagagtcat ttgcaaagag tgtccaggaa ttgacaattg ttttgcaacg     1620

aacaggtgac ccagctaact taaatagact gaggcctcat ttagagcttc ttgcaaacat     1680

agaccctaat ccagacgctg tttcaccaac ttgggagcag ctggaaaatg caatggtagc     1740

tgttaaaaca gtagttcatg gccttgtgga cttcatacaa aattatagta gaaaaggcca     1800

tgagacccct cagcctcagc caaacagcaa atacaagact agcatgtgcc gagatttgcg     1860

acagcaaggg ggttgtccac gaggaacaaa ttgtacattt gcccattctc aggaagagct     1920

tgaaaagtat cgattaagga acaaaaagat caatgccact gtaagaacgt ttcctcttct     1980

aaataaagtt ggtgtaaaca acactgtcac aaccacagcc ggaaatgtca tttctgtcat     2040

aggaagtact gaaacaacag ggaaaattgt tccaagtaca aacggaattt caaatgcaga     2100

aaacagtgtt tcccagctaa tctcacgtag tactgacagt accttaagag ctctggagac     2160

cgtgaagaaa gtgggaaagg ttggcgctaa tggtcagaat gctgctgggc cctctgcaga     2220

ttctgtaact gaaaataaaa ttggttctcc acccaagact cctgtaagta atgtagcagc     2280

tacctcagct gggccctcta atgttggaac agagctgaat tctgtgcctc aaaaatccag     2340

cccatttcta actagagtac cagtatatcc tccgcattct gaaaacattc agtattttca     2400

agatccaagg actcagatac cctttgaagt cccacagtac ccacagacag gatactatcc     2460

accacctcca acggtaccag ctggtgtggc tccctgtgtt cctcgctttg tgaggtccaa     2520

taacgttcca gagtcctccc tcccacctgc ttccatgcca tatgccgatc attacagtac     2580

attttcccct cgagatcgaa tgaattcttc tccttaccag cctcctcctc cgcagccgta     2640

tggaccagtt cctccagtac cttctggaat gtatgctcct gtgtacgaca gcaggcgcat     2700

ctggcgccca cctatgtacc aacgagatga cattattaga agcaattctt tacctccaat     2760

ggatgtgatg cactcatctg tctatcagac atctttgcgg gaaagatata actcattaga     2820

tggatattat tcggtggctt gtcagccacc aagtgagcca aggacaactg tgcctttacc     2880

aagggaacct tgtggtcatt tgaagaccag ttgcgaggag cagataagaa gaaagccaga     2940

tcagtgggca cagtaccaca ctcagaaagc acctcttgtc tcttcaactc ttcctgtggc     3000

aacacagtca ccaacaccac cttctcctct gttcagtgta gactttcgtg cggatttctc     3060

agagagtgtg agtggtacaa aatttgaaga agatcatctt tcccattatt ctccctggtc     3120

ttgtggcacc ataggctcct gtataaatgc cattgattca gagcccaaag atgtcattgc     3180

taattcaaat gctgtgttaa tggacctgga cagtggtgat gttaagagaa gagtacattt     3240

atttgaaacc cagagaagga caaaagaaga agatccaata attcccttta gtgatggacc     3300

catcatctca aaatggggtg cgatttccag atcttcccgt acaggttacc ataccacaga     3360

tcctgtccag gccactgctt cccaaggaag tgcgactaag cccatcagtg tatcagatta     3420

tgtcccttat gtcaatgctg ttgattcaag gtggagttca tatggcaacg aggccacatc     3480

atcagcacac tatgttgaaa gggacagatt cattgttact gatttatctg gtcatagaaa     3540

gcattccagt actggggacc ttttgagcct tgaacttcag caggccaaga gcaactcatt     3600

acttcttcag agagaggcca atgctttggc catgcaacag aagtggaatt ccctggatga     3660

aggccgtcac cttaccttaa accttttaag caaggaaatt gaactaagaa atggagagtt     3720

acagagtgat tatacagaag atgcaacaga tactaaacct gatagggata tcgagttaga     3780

gctttcagca cttgatactg atgaacctga tggacaaagt gaaccaattg aagagatctt     3840

ggacatacag cttggtatca gttctcaaaa tgatcagttg ctaaatggaa tggcagtgga     3900

aaatgggcat ccagtacagc agcaccaaaa ggagccacca aagcagaaga aacagagttt     3960

aggtgaagac catgtgattc tggaggagca aaaaacaatt ctgccggtaa cttcttgctt     4020

tagccagcca ctcccagtgt ctattagcaa tgcaagttgc ctccccatca ccacatctgt     4080

cagtgctggc aacctcattc tgaaaactca tgttatgtct gaagataaaa acgacttttt     4140

aaaacctgtt gcaaatggga agatggttaa cagctgaaag gaggttcatc tttcaaattt     4200

gtgaccacac catggaagca tttacactag ctttttatat atataatata tattatataa     4260

tgtatatttt ttttaaaaaa aagatattac tgggggcatc catttcctgt ggactctttg     4320

atacttcaag ccctcttgca ttagcattat gaaaaaaaaa aagaaaattt actttactag     4380

ggtaacatgt tcactttcca gaaatgattg gaatttggac aacatttaac ttaagcttca     4440

agcagctttt tatgagtttg tagcaatccg gtgcagtaac tgagccattt cctattttaa     4500

atggcttcta tagaaaatta acaactcagt tattaaacta gcaggatcct acaatgatac     4560

atctagtgaa agtagactta gttaacttat ttatttctat tttatgtttc actgagagaa     4620

gtttccatct cattccagct gctttattta tctttttcat ggaactttgc atggatttct     4680

ttttcttttt ttaattttga agagtggagt tagatgttct taccatagaa ttttacaggg     4740

ttatatacta gcattcttta ctgcattata tgtaggagtg tggtgcagtg cttttatctg     4800

tagcatataa ttttttttta attttccatt tttcaagagt agtttctgct ttgttaatat     4860

ttatacacag gctacttgtt gaagtaatta attaaaaata taaccaagtg cctaagtctt     4920

tcagctgatg tactagatat taaattctcc taagttatgc agaatcgttt ttacaatttt     4980

gataaattat gcactaatgt aatggcagtt ttttaaaatg cagatttaag cctgtacatt     5040

attgaatctg atgacttggc aaaagaatca ggtgctttca gctttcttga gaaaaccctg     5100

tatgtagcgt ttgcactgac taacaagatg gtattgctgg gtttttaatt taaactaatt     5160

aatttggttg ttcattgcat tatcttggtt aaatattgtt tattgttact tcatgttggg     5220

gtttagtttt tcttgttttt tgactgttag gttgataaga ctatgaactg tgtaatagta     5280

gaacagtggc taacatttat tcatacttaa gaacatgaat aatttctgcc ttgctaaaat     5340

gtgactgaaa tggttttgac ttggcatctg aaagtataca atgtgttcaa caagtcatgc     5400

atcagatttg tgggaggtat tgtactgaaa cctaaatttc agtcaacatt tgaaaagaag     5460

agctgggcat tccttcctgg tgatctttac ctatagttta tctatctgtt tttcttctgt     5520

ttctttaaga ttagtttgac ttttattatt atttttttaa ttaacttctg tgaagttgtt     5580

tactctgaaa attgtactgg aatattttaa gccaagctga tctttcacca ggtgtactgt     5640

atgtaagggc ttttcctgct agcaagatgc ttaaacagga tcatgttatt ggtcgtctga     5700

gctatttagt tgttttacaa aaccacagca ttgtatcaga taagattttg ataaaaagtt     5760

ttgtgcacat ttccaggggc gggagggttg acatttccct gaaatttctt gattagaatg     5820

agtaaatact ggtgtttgat acctgtctta atgaacatgc tcataaggtg actgataagt     5880

tgtaaatata cctgagaaac aaaggggtag ttttgatatt ctggtgtcag tatggaagat     5940

cttacacatt tatttaatac tcaaatgtat gaagatgttt gtttgtagca taacaacagc     6000

acagtagcct tgacttagtt tcctttggtt agtactgtac cttttttgcc atggccagtg     6060

ctccccatcc ctatgaagac attttattta tttcactctg taacctgaaa tgaataggaa     6120

caagggtttt aaaccatgtt acattaactt ttctgacatt ataaattagc ctagaatatt     6180

acaggaacat gattgttata taatttatat cagaaccttt ctataaatat gtgcttatta     6240

catttgaaat gcttccaatg tactttattt gctgtttgta attccaaaaa ggatatgcaa     6300

accagtctgt ctatttcatg gatatttaat agtgagatct tccatgttga aggtaatgta     6360

ttttttttta agattttaaa attgctattt tgttacaaaa tagagaccta ttaacagttt     6420

gagagctcct tatgtgccct cagggaaaga accctctgtg caacagaact acacaaaaca     6480

tcttcagcac gttctgaggg tgaatatata ctacataaat tgatcttgtg tatttaacct     6540

tatcttttta attttaaaat tgaaattttg aaacttggtt gtgctctgct ggagggggtt     6600

gggataaact gcttagatgt ttgcctactt gtccagtgaa attacatttg catcagtata     6660

tgtatatacc tgccaacctt attggtatgt ctcagaacat ttatattaaa ataatgcttg     6720

tcttgcagca ggtgatccca taaaacaata actccctgtt cttaaaaact tactctcttt     6780

ttcactaaca acataggaat tgtttctgtg ttgagattat tctgtgttgc atccattctc     6840

tatgtagtgg tcaccttctg tctgtcatgg tgggcttaat gtgaagtaaa gccattggtt     6900

ctctgccact ttcgaagaaa gggcagttca tctgatcctt cttcagaatg gtacctactg     6960

atatcatcga ggaaaatgtt acaaatcaga cctaggatat gactttttaa aattgaggca     7020

tttcccgtca tttggccttt ttaccaacaa gatgtgatgt acaaatttgg aatcaaagga     7080

tacaaagcaa caagagagga aatgtgtaat gtgggtaacc aaactgcata tgttacctat     7140

tgtctaatca gaaaaaatag tctgaggtct ggaaagcagg aaagtggtgg ttattttctt     7200

tcattttttg tgtttttgtt ttttaatttc taagttccat tctgaaatcc atgtgccgca     7260

ttcagttact gtggttgtag catcagtttt tttgtggttt catttcattt tatgaattca     7320

gaggaagtta catatatatt ttttctagtt ggtacctgaa caaagcagat tcccttgcct     7380

ttgctgccac gtcttatttt caatgccatg tgataaacca gtgtcataca tgaaagttgt     7440

gcattgtaat tttcaaaaaa aagggagttc attaggccag tggcactgat ttttccttcc     7500

catcatagct atttattcta gtaagaggat aataaaagaa atttcctata caagaactga     7560

aattttccat ttgtatggat ctagtcactt tcagatttca atttgaggtt aagtatataa     7620

agcacatccc aattttatat gctgccttga gaaaattaca ggatgcacgg caatttgtag     7680

gaatttcaaa tgggatcatt taaacatttg aaaaattatt ttaaaaacca tctagtttgc     7740

ttttggattt tagacattaa agcctatgtt gtcttgttaa caggggtgga atgtataacc     7800

atcagattca gcatgtgatt tcacctttga atctgagtat ttcttcccta tcttctttga     7860

gtcatttttg gagcagactg tcaccagtat tgataactaa gcattaaagg gaaaagttgc     7920

attgcaacta tgcattggtt tcctggaaga acttttcttt tgttttagtg aatgaagagg     7980

cttgatggga tcacttactg taactccttc tacataagga ccccttctgc aagcagaaca     8040

caaaagaaca tgctcaagga gtatcccatt ttctggataa attgaagaag tttgctagta     8100

atgtctttat actagcgtct tccttgtatc cctttgctgg caagggaata caaggcgtca     8160

agaccacaga tcaaaacacc ccacatttga gtggagtctt atttttactc caagagcagt     8220

tattcccttc tagtctaaaa ttggcagttt tttctttttt ttaataaaat ttttaaaata     8280

ttcccaaacc agtggaacac agacactggc tgcacttagt actgccaaaa gccaaggtca     8340

tttgcacata ttccatcaac ctgtcgagaa ttaggcctca ctttataacc caaggcatgg     8400

aagtgcatgc attctcttag ctgggcaaac aattatactg tagttgtgat acaacacatg     8460

tggcttttat ttgtactgca catatccact gtacagccac ttgggagtat cgtggttagc     8520

ttgcagcaac tgctgtctgc atttatactg tttattgcat attcttttcc ctggaagtga     8580

aagagaaatg tttttcttgt tgcattgatt acattttata aatttgctta gctggaaagt     8640

ttgggaaaag aggcctgttt gtcaattgta caaccgattg tgaagctcta gtgtgaatat     8700

ttttacgtct gtattagaca ttttctttgc aaatctattg ttcgattgaa atgtaaatga     8760

aattaaagat ggtgtacacc catcatgtaa aaagcaggca ccatctctaa gatggattta     8820

atgctcattt ttaaggcata tactcagctt ctatttaaaa ctataattta aaataattct     8880

gtacaatgaa atggggaata tatatgggaa taaattctat tccatttatt tcaatttgaa     8940

tttccaaatt gtaatgtttc cctttgtgct ataggaatag gattaaatgg gggaagacta     9000

ggatttataa ggcctgtata tggggggagg gcagagatgg aacaatgagg gttgtgatga     9060

tagtgaatag caaagagtga attctgtgtg tttttgctgt agcactgaag tgaagagata     9120

ttagctttgg ctgttcacaa aatagagcat catgattttc agtgtttgag agaaaattga     9180

tggaaaaagt ttgcagtact tgacatgtat ttgcatgcac aaaataaaat tatttgtcca     9240

ccttaaaa                                                              9248


<210> 1856
<211> 1669
<212> DNA
<213> Homo sapiens

<400> 1856
gcgctgcccg gctcccggcc ctgccggcct cctcccttgg cgccgcggcc atggcggcca       60

gcgcgaagcg gaagcaggag gagaagcacc tgaagatgct gcgggacatg accggcctcc      120

cgcacaaccg aaagtgcttc gactgcgacc agcgcggccc cacctacgtt aacatgacgg      180

tcggctcctt cgtgtgtacc tcctgctccg gcagcctgcg aggattaaat ccaccacaca      240

gggtgaaatc tatctccatg acaacattca cacaacagga aattgaattc ttacaaaaac      300

atggaaatga agtctgtaaa cagatttggc taggattatt tgatgataga tcttcagcaa      360

ttccagactt cagggatcca caaaaagtga aagagtttct acaagaaaag tatgaaaaga      420

aaagatggta tgtcccgcca gaacaagcca aagtcgtggc atcagttcat gcatctattt      480

cagggtcctc tgccagtagc acaagcagca cacctgaggt caaaccactg aaatctcttt      540

taggggattc tgcaccaaca ctgcacttaa ataagggcac acctagtcag tccccagttg      600

taggtcgttc tcaagggcag cagcaggaga agaagcaatt tgacctttta agtgatctcg      660

gctcagacat ctttgctgct ccagctcctc agtcaacagc tacagccaat tttgctaact      720

ttgcacattt caacagtcat gcaggtggaa gtgctgcatc agtaaatgct aattttgctc      780

attttgataa cttccccaaa tcctccagtg ctgattttgg aaccttcaat acttcccaga      840

gtcatcaaac agcatcagct gttagtaaag tttcaacgaa caaagctggt ttacagactg      900

cagacaaata tgcagcactt gctaatttag acaatatctt cagtgccggg caaggtggtg      960

atcagggaag tggctttggg accacaggta aagctcctgt tggttctgtg gtttcagttc     1020

ccagtcagtc aagtgcatct tcagacaagt atgcagctct ggcagaacta gacagcgttt     1080

tcagttctgc agccacctcc agtaatgcgt atacttccac aagtaatgct agcagcaatg     1140

tttttggaac agtgccagtg gttgcttctg cacagacaca gcctgcttca tcaagtgtgc     1200

ctgctccatt tggagctacg ccttccacaa atccatttgt tgctgctgct ggtccttctg     1260

tggcatcttc tacaaaccca tttcagacca atgccagagg agcaacagcg gcaacctttg     1320

gcactgcatc catgagcatg cccacaggat tcggcactcc tgctccctac agtcttccca     1380

ccagctttag tggcagcttt cagcagcctg cctttccagc ccaagcagct ttccctcaac     1440

agacagcttt ttctcaacag cccaatggtg caggttttgc agcatttgga caaacaaagc     1500

cagtagtaac cccttttggt caagttgcag ctgctggagt atctagtaat ccttttatga     1560

ctggtgcacc aacaggacaa tttccaacag gaagctcatc aaccaatcct ttcttatagc     1620

cttatataga caatttactg gaacgaactt ttatgtggtc acattacat                 1669


<210> 1857
<211> 2126
<212> DNA
<213> Homo sapiens

<400> 1857
aaatgctctg gctccggtgg tgacaggttg tccagcttct tacagccatc ttcactgaaa       60

ctaaggttaa ctcctcactc tctatggacg gctactctct atttccaagg gcgtgaagaa      120

tttccctctt ctcctgtgct ttcatctaaa agttctccct ggataattat cattgcagtg      180

gagtgcctgg attggacatc ctcatctggg tcaactaaaa aaagaaagca tgcaagacga      240

cagcatagaa gcttctactt ccatatctca gcttctaaga gagagctatt tagctgaaac      300

cagacatcgg ggaaacaatg agaggagtcg agcggagccc tcctccaacc cttgccattt      360

cggcagtcct tctggggccg ctgaaggagg cggaggccaa gatgaccttc cagatctttc      420

agcctttctg agccaagaag aattagacga aagtgtcaat ttggcaagac tggccatcaa      480

ttacgaccct ttggagaagg cagatgaaac tcaagctaga aaacgacttt ctcctgatca      540

gatgaaacac tcacctaatt taagttttga gcctaacttc tgccaggata accctcgaag      600

tcccaccagc tctaaagaaa gcccccagga ggcaaaaagg ccacagtatt gttctgaaac      660

ccagtccaaa aaagtatttt taaataaggc tgccgacttc attgaagagc tatcctccct      720

tttcaaatcc cacagctcca aaaggattag acctcgtgcc tgcaaaaacc acaagagtaa      780

actggaatct caaaacaaag ttatgcagga aaacagctcc agtttctcag atctgtcaga      840

aagacgagaa agatcttctg ttcccatccc tatccctgcg gataccaggg ataatgaagt      900

gaatcacgcc ctggaacagc aggaagccaa gaggcgtgaa gcggagcagg ctgccagtga      960

ggcggctggt ggagacacta caccagggtc ttccccttca tctctgtact atgaagaacc     1020

tctggggcaa cctccccggt tcactcaaaa gttacggagc agagaagttc cagaaggaac     1080

tcgagtacag ttggattgca tagtggtagg aattccacca cctcaagtaa ggtggtactg     1140

tgaaggcaag gagcttgaaa attccccaga tattcacatc gtccaggcag gaaatctgca     1200

ctcactgacc attgcggaag cctttgaaga ggacacagga cgctattcct gctttgcttc     1260

taacatctat gggacagatt cgacttctgc tgagatttat atagaagggg tttcttcttc     1320

tgactcagaa ggcgacccta acaaggaaga gatgaatcga atccagaagc caaatgaggt     1380

gtcatctcct cccactacct ctgcagtcat tcctccagca gtaccccaag cccagcattt     1440

ggtggcccaa cctcgtgtgg caaccatcca gcagtgtcag agccccacca attacttgca     1500

gggattggat ggaaaaccta tcattgcagc tcctgtgttt acaaagatgc tacaaaattt     1560

gtcagcttct gagggtcagc tggttgtctt tgaatgcaga gtaaaaggag ctccatctcc     1620

taaggttgag tggtatagag aagggacttt aatagaagat tctccagatt ttaggatttt     1680

acagaaaaaa cctcgatcca tggcagagcc aggtaaagat gatttcaact ttaatttatt     1740

agtatatgag tgattttata tatacaagaa tacataatga agttacactg agatgaataa     1800

aaagtgaaaa ataaagtttt aggaaaaaaa gatccaaatg ggccgggtgc agtggctcat     1860

gtctgtaatt ccagcacttt gcgaggccga ggcgggcgga ttacttgaga tcagaagttc     1920

aagaccagcc tggcctacat gacaaaatga aaccccatct ctactaaaaa tataaaaatt     1980

agccaggcat agtggcgcac gtctgtaatc ccagctacct gggaggctga ggcaggagaa     2040

tcacttgagc ctgggaggtg gaggttgcag tgagccgaga tcgtgacact acagtccagc     2100

tgcgcgacag aacaagaatc tgtctc                                          2126


<210> 1858
<211> 3905
<212> DNA
<213> Homo sapiens

<400> 1858
acttccggcc agcccctccc ccgcctccct cgcgtggcca cctccccctc tgccttctcc       60

tacccagtct cttccccaac tctccccacc cctggtgctc tccgccccgc ttgcctcccg      120

ttcttccccg cccgctccat ccgggtcgct gacggctgtc tctggactgg acagcagtgg      180

cgtccgcttt tctctaagga acccgataag aactccattt tctgttgatg tggagacata      240

gggtacctcc aactttccgg ggtttcagaa gagaattttt tattgaaact ggaagaccaa      300

aataattaca agcatgttgt gctggggaaa tgcatccttt gggcagctag gtttgggtgg      360

aattgatgaa gaaattgtac tagagcccag aaaaagtgac ttctttataa ataaaagggt      420

ccgagatgta ggatgtggac tcagacatac tgtgtttgtt ctggatgatg gaacagtgta      480

cacatgtgga tgtaatgatc taggacagct aggtcatgaa aaatccagaa agaaaccaga      540

gcaggttgtt gccctggatg cccaaaatat tgtagctgtt tcatgtggag aagctcatac      600

gttagcgcta aatgacaaag gccaggtgta tgcttggggt ctcgattctg atggacagct      660

tggcctggta ggatcagagg aatgcatcag agtacccaga aatattaaaa gtttgtcaga      720

tatccagatt gtacaggttg cttgtggtta ctatcattca cttgcacttt ctaaagcaag      780

tgaagtcttc tgttggggac agaataaata tggccaattg ggtttaggta ctgactgtaa      840

aaagcaaact tcaccgcagc tgcttaagtc tttgcttgga atccctttca tgcaagttgc      900

agcaggagga gcccatagtt ttgtactcac cctttctgga gctatctttg gatggggacg      960

caacaagttt ggtcagctag gtcttaatga tgaaaatgat aggtatgttc ctaatttact     1020

aaagtcacta agatctcaga aaatagttta tatttgttgt ggagaagatc atactgctgc     1080

tctaaccaag gaaggtggag tgtttacttt tggagctgga gggtatggtc agttgggcca     1140

taattctacc agtcatgaaa taaacccaag gaaagttttt gaacttatgg gaagcattgt     1200

cactgagatt gcttgtggac ggcagcacac ttctgctttt gttccttcat caggacgaat     1260

ttactctttt gggcttggtg gtaatgggca gctgggaacc ggttcaacaa gcaacaggaa     1320

aagccccttt actgtaaaag gaaattggta cccctataat gggcagtgtc taccagatat     1380

tgattctgaa gaatatttct gtgtaaaaag aattttctca gggggagatc aaagcttttc     1440

acattactct agtccccaga actgtgggcc accagatgac ttcagatgtc ccaatccgac     1500

aaagcagatc tggacagtga atgaagctct aattcagaaa tggctgagct atccttctgg     1560

aaggtttcct gtggagatag ccaatgagat agatggaacg ttttcttcct ctggttgcct     1620

aaatggaagt tttttagctg ttagcaatga tgatcactat agaacaggta ccagattttc     1680

aggggttgat atgaatgctg ctaggctttt attccacaaa cttatacaac ctgatcatcc     1740

gcagatatct cagcaggtgg cagctagttt ggaaaagaat cttattccta aactgactag     1800

ctccttacct gatgttgaag cattgaggtt ttatcttact ctaccagaat gtcccctgat     1860

gagtgattcc aacaatttca caacaatagc aattcccttt ggtacagctc ttgtgaacct     1920

agaaaaggca ccactgaaag tacttgaaaa ctggtggtca gtacttgaac ctccactatt     1980

cctcaagata gtagaacttt ttaaggaagt tgtggtacat cttttgaaac tctacaagat     2040

cggtattccc ccttctgaaa gaagaatttt caacagtttt cttcatactg cattaaaggt     2100

tttagaaata ctacataggg taaatgagaa aatgggacag attatacagt atgataaatt     2160

ttatatacat gaagtacaag aattgataga cataagaaat gattatatca actgggtcca     2220

acagcaggcc tatggaatgt tggcagatat ccctgttaca atctgtacat atccatttgt     2280

atttgatgcc caagcaaaaa ctactctgtt acagaccgat gcagtcttac agatgcagat     2340

ggctattgat caggcccaca ggcagaatgt ctcctctctt tttctcccag tgattgaatc     2400

tgtgaatccc tgcttaattc tagtggtgcg tagagaaaat attgtaggag atgcaatgga     2460

agtccttagg aaaacaaaga acatagatta caagaagcca ctcaaggtta tatttgttgg     2520

agaagatgct gtggatgcag gaggggtgcg caaagaattt ttcttgctca tcatgaggga     2580

attattggat cctaaatacg gcatgtttag gtattatgaa gattccaggc tcatttggtt     2640

ttctgataag acatttgaag acagtgattt gttccatttg attggtgtta tctgtggctt     2700

agcaatttat aattgtacca ttgtggacct ccattttcct ttggctttat ataagaaact     2760

actgaaaaag aagccatcct tggatgattt gaaagaacta atgcctgatg ttgggagaag     2820

catgcaacag ttactggatt atccagaaga tgacatagag gaaacatttt gtcttaattt     2880

tacgatcaca gttgaaaact ttggtgcaac agaagtgaaa gagctggttc taaatggtgc     2940

agacacagct gttaacaaac aaaatcggca agagtttgtc gatgcttatg tggattacat     3000

attcaataaa tcagtggctt ccttatttga tgcttttcat gcgggctttc ataaggtctg     3060

tggaggaaaa gtccttctgc tctttcagcc taatgaacta caagcaatgg tcattggaaa     3120

tacaaattat gattggaagg aactggaaaa gaatacagaa tacaaagggg aatattgggc     3180

agaacatcct acgataaaaa ttttttggga agtatttcac gaattaccat tggaaaagaa     3240

gaaacagttt ctgttatttt tgacaggtag tgatcgcatt cctattcttg gtatgaagag     3300

tctgaaacta gtcatccagt ccacaggagg tggtgaggag tatctcccag tttcccatac     3360

ttgttttaat cttctggatc ttccaaaata tacagaaaaa gaaactctac gctctaaact     3420

gatccaagct attgatcaca atgaaggctt cagtttaata taactttgga gttataacta     3480

ttcagtttag tgcaaaagca ttaaactatt tgtgtttttc ttgtggtgat gaattcagca     3540

aggtgacaga ggtactatta taattcttac ttgcagaatg ttcaatctac gagtgttcat     3600

ggaagccaaa aaatattaaa ggaaaatgaa caaactgtta atattattgt acagaaccat     3660

ggattttttt tgaccatctt ctaataaaca tagcaagtat tatgaataca ttaaagtttt     3720

actaacatga attttaagag tttgcatatt tcagaaatga tctggtgtga gtgcatggaa     3780

atattgctta atttttcttc aatcattgag tgaaaaacct ttaactttgg cctgcaatag     3840

tcatttgatt attttttcat tttgtaaata atgttaagtt ttgtaataaa atagttatgt     3900

tctga                                                                 3905


<210> 1859
<211> 1730
<212> DNA
<213> Homo sapiens

<400> 1859
acgcgctggc tgactggggt cggcgtttag ttcagcgcag cgactcgggg acctggagct       60

gacgcctagt acgtatgagg aagaacgggg tgggtggctg cctgagtctg gaggcgacgc      120

ctcggttgtg cagtctgaac ctgcccttct cagctgaggg tgctgacagc aaggggtggg      180

aggcgggccc cgagtcccca gctgtggaca cttgtattag ctttaataga agagaaatgg      240

aggagccata gaatattaag gatgaattca ggaaggcctg agaccatgga aaacttgcct      300

gctctctaca ctattttcca aggagaggtt gctatggtga cagactatgg ggcctttatc      360

aaaatcccag gctgtcggaa gcaaggtctg gtccatcgaa ctcatatgtc atcctgtcgg      420

gtggataagc cctctgagat agtagatgtt ggagataaag tgtgggtgaa gcttattggc      480

cgagagatga aaaatgatag aataaaagta tccctctcca tgaaggttgt caatcaaggg      540

actgggaaag accttgatcc caacaatgtt atcattgagc aagaagagag gcggaggcga      600

tccttccagg attacactgg gcagaagatc acccttgagg ctgtcttgaa cactacctgc      660

aagaagtgtg gctgtaaagg ccactttgca aaagattgtt tcatgcaacc aggtgggact      720

aaatactctc tgatacctga tgaggaagag gaaaaggaag aggcaaagtc agcagagttt      780

gagaagcctg accctacaag gaatccttct agaaaaagaa agaaggagaa gaagaaaaag      840

aaacatagag ataggaagtc atctgactct gacagctcag actctgagag tgatacaggc      900

aagagggcaa ggcacacatc aaaagacagc aaggcagcaa agaagaagaa aaagaagaag      960

aagcacaaga agaagcacaa ggagtgagag tataaagagt gtagggggtg gttgagagta     1020

agaaaccagg agccttgtgc cttgagactc ctggaaagac tcaatagtga gaatatagcc     1080

tcccacccca ttaacttcgc tcccatggga gatggcttcc cctcatgcaa caggcaggtt     1140

tgggagttag aggtcaaaag cagctgcctg aatgagttgt tgtttcctta tcactcctgg     1200

tccctttgca agtgaaccct gcagctcacc cattcattca cccaacttcc ttcattcagc     1260

aggaggtcct attaccctct ccagctgcca ctgccagagc tggattcctg taaaggagtc     1320

caggctagag ccacagagac tgttgtggag gtgagttcgg ctgtagttag agtgattgga     1380

cccttcctat tggtctgtcc tgggccaact ggtgggtgat ctctgctgca tccaacatgg     1440

gagcagagac tggcagcagg aggggggaac atggtgagaa gtggtgctca cttttcccat     1500

tcctcctaac atagttctac tatgctagaa gtggcatcca gcggccacag ctagaaaaca     1560

gtctgcagtg tgacttaact tgtgtattgc attccagcag accactgaac cagacagcga     1620

agccaagatc attgttctac tttgtattta ctactgtgtg aatcagttga ttctacttca     1680

ggtccttgct taaattcctg tcactaaatg gaaatgtgtt tggttttaaa                1730


<210> 1860
<211> 1867
<212> DNA
<213> Homo sapiens

<400> 1860
atgatcatca attggaatca agtctcagtc ctgtggaagt gtttgctaaa acaatctgcc       60

agttatcaag acaggaggca atcctggcgg cgagcaagta tgaaagaaac gaaccggcgg      120

aagtcgctgc atcccattca ccagggcatc acagagctca gccggtctat cagtgtcgat      180

ttagcagaaa gcaaacggct tggctgtctc ctgctttcca gtttccagtt ctctattcag      240

aaacttgaac ctttcctaag ggacactaag ggcttcagtc ttgaaagttt tagagccaaa      300

gcatcttctc tttctgaaga attgaaacat tttgcagacg gactggaaac tgatggaact      360

ctacaaaaat gttttgaaga ttcaaatgga aaagcatcag atttttcttt ggaagcatct      420

gtggctgaga tgaaggaata cataacaaag ttttctttag aacgtcagac ttgggatcag      480

ctcttgcttc actaccagca ggaggctaaa gagatattgt ccagaggatc aactgaggcc      540

aaaattactg aggtcaaagt ggaacctatg acatatcttg ggtcttctca gaatgaagtt      600

cttaatacaa aacctgacta ccagaaaata ttacagaacc agagcaaagt ctttgactgt      660

atggagttgg tgatggatga actgcaagga tcagtgaaac agctgcaggc ctttatggat      720

gaaagtaccc agtgcttcca gaaggtgtca gtacagctcg gaaagagaag catgcaacaa      780

ttagatccct caccagctcg aaaactgttg aagcttcagc tacagaaccc acctgccata      840

catggatctg gatctggatc ttgtcagtga ctttatgaga gtttctgcca caaggtgccc      900

aagaggagag gaatgggaag agtgccccag cacgtggtga ctgcgtgatt tctgctcgtt      960

gcctttgaag ataactggca ggactgactg tagaacactt tgactttttt caaaaagtga     1020

tggaatttgt acatccaaat gaatattgta tagacaattt tcccaggaat gtgcaaaatg     1080

cttgaaagtt caaacttctt ttttgaaatg atcttcagat ccagtggccc attcttttat     1140

ctttatcctg tgaaggtgtt tttcaggttt tgaaacaatc caaaaatcat ttaggaccaa     1200

gtctaaggaa acattttagt ggccaagttg gattccgatt gtaaaggaat gatactaatt     1260

ttctagcatg gctctgaagg tgattttagg tagaagagtt ttgaggctgg gcgcaatggc     1320

tcacgcctgt aatcctagca ttttgggtga ctgaggcggg tggattgctt gagcccagaa     1380

gttgaagacc agcctgagaa ataaggtgaa accctgtcta caaaaaatac aaaaagttag     1440

ctgggtgtgg tggcgtgtgc ctgtagtgct agctactcag aaggctgagg tgggaggatt     1500

gtttgagccc aggaggttga ggctgcagtg agttctaatt gcgccactgc actccagcct     1560

gagcgacaga gtgagacact gtcttaaaaa aaattaaaaa ttgtaaaaaa atgaaaaaaa     1620

aagttttgag cattatttgc atcattggga tacatatgtc acttcacaag atgttcaatt     1680

tgaaggaaat accactcatt ctctatgtcc tgttgtctgt agtgtgcttc agtttttcat     1740

attgagttga cctaaatcct ggattcatga caagaaagga gtaagtacta ctattcattg     1800

ttctatttgt ttataatctg tattataaaa ttgcacataa ttaaaagctt tcccttgtct     1860

tcatcta                                                               1867


<210> 1861
<211> 1915
<212> DNA
<213> Homo sapiens

<400> 1861
gcatgcgccc ttggttggcg ggagtttcgg aggcggtgac cgtgacgtag aaggtggaga       60

ccgcttcacc ctgatcaggg agtatcggct gcgggtgcgc aaggcgtcca ggagtgacct      120

ggggctgtgg agagcgaccc gtggccttgt gtttcagagt ttaccaccta ggatgacttc      180

agtgactaga tcagagatca tagatgagct cagccggtct atcagtgtcg atttagcaga      240

aagcaaacgg cttggctgtc tcctgctttc cagtttccag ttctctattc agaaacttga      300

acctttccta agggacacta agggcttcag tcttgaaagt tttagagcca aagcatcttc      360

tctttctgaa gaattgaaac attttgcaga cggactggaa actgatggaa ctctacaaaa      420

atgttttgaa gattcaaatg gaaaagcatc agatttttct ttggaagcat ctgtggctga      480

gatgaaggaa tacataacaa agttttcttt agaacgtcag acttgggatc agctcttgct      540

tcactaccag caggaggcta aagagatatt gtccagagga tcaactgagg ccaaaattac      600

tgaggtcaaa gtggaaccta tgacatatct tgggtcttct cagaatgaag ttcttaatac      660

aaaacctgac taccagaaaa tattacagaa ccagagcaaa gtctttgact gtatggagtt      720

ggtgatggat gaactgcaag gatcagtgaa acagctgcag gcctttatgg atgaaagtac      780

ccagtgcttc cagaaggtgt cagtacagct cggaaagaga agcatgcaac aattagatcc      840

ctcaccagct cgaaaactgt tgaagcttca gctacagaac ccacctgcca tacatggatc      900

tggatctgga tcttgtcagt gactttatga gagtttctgc cacaaggtgc ccaagaggag      960

aggaatggga agagtgcccc agcacgtggt gactgcgtga tttctgctcg ttgcctttga     1020

agataactgg caggactgac tgtagaacac tttgactttt ttcaaaaagt gatggaattt     1080

gtacatccaa atgaatattg tatagacaat tttcccagga atgtgcaaaa tgcttgaaag     1140

ttcaaacttc ttttttgaaa tgatcttcag atccagtggc ccattctttt atctttatcc     1200

tgtgaaggtg tttttcaggt tttgaaacaa tccaaaaatc atttaggacc aagtctaagg     1260

aaacatttta gtggccaagt tggattccga ttgtaaagga atgatactaa ttttctagca     1320

tggctctgaa ggtgatttta ggtagaagag ttttgaggct gggcgcaatg gctcacgcct     1380

gtaatcctag cattttgggt gactgaggcg ggtggattgc ttgagcccag aagttgaaga     1440

ccagcctgag aaataaggtg aaaccctgtc tacaaaaaat acaaaaagtt agctgggtgt     1500

ggtggcgtgt gcctgtagtg ctagctactc agaaggctga ggtgggagga ttgtttgagc     1560

ccaggaggtt gaggctgcag tgagttctaa ttgcgccact gcactccagc ctgagcgaca     1620

gagtgagaca ctgtcttaaa aaaaattaaa aattgtaaaa aaatgaaaaa aaaagttttg     1680

agcattattt gcatcattgg gatacatatg tcacttcaca agatgttcaa tttgaaggaa     1740

ataccactca ttctctatgt cctgttgtct gtagtgtgct tcagtttttc atattgagtt     1800

gacctaaatc ctggattcat gacaagaaag gagtaagtac tactattcat tgttctattt     1860

gtttataatc tgtattataa aattgcacat aattaaaagc tttcccttgt cttca          1915


<210> 1862
<211> 1922
<212> DNA
<213> Homo sapiens

<400> 1862
gcaaggcgtc caggagtgac ctggggctgt ggagagcgac ccgtggcctt gtgtttcaga       60

gtttaccacc taggatgact tcagtgacta gatcagagat catagatgaa caatctgcca      120

gttatcaaga caggaggcaa tcctggcggc gagcaagtat gaaagaaacg aaccggcgga      180

agtcgctgca tcccattcac cagggcatca cagagctcag ccggtctatc agtgtcgatt      240

tagcagaaag caaacggctt ggctgtctcc tgctttccag tttccagttc tctattcaga      300

aacttgaacc tttcctaagg gacactaagg gcttcagtct tgaaagtttt agagccaaag      360

catcttctct ttctgaagaa ttgaaacatt ttgcagacgg actggaaact gatggaactc      420

tacaaaaatg ttttgaagat tcaaatggaa aagcatcaga tttttctttg gaagcatctg      480

tggctgagat gaaggaatac ataacaaagt tttctttaga acgtcagact tgggatcagc      540

tcttgcttca ctaccagcag gaggctaaag agatattgtc cagaggatca actgaggcca      600

aaattactga ggtcaaagtg gaacctatga catatcttgg gtcttctcag aatgaagttc      660

ttaatacaaa acctgactac cagaaaatat tacagaacca gagcaaagtc tttgactgta      720

tggagttggt gatggatgaa ctgcaaggat cagtgaaaca gctgcaggcc tttatggatg      780

aaagtaccca gtgcttccag aaggtgtcag tacagctcgg aaagagaagc atgcaacaat      840

tagatccctc accagctcga aaactgttga agcttcagct acagaaccca cctgccatac      900

atggatctgg atctggatct tgtcagtgac tttatgagag tttctgccac aaggtgccca      960

agaggagagg aatgggaaga gtgccccagc acgtggtgac tgcgtgattt ctgctcgttg     1020

cctttgaaga taactggcag gactgactgt agaacacttt gacttttttc aaaaagtgat     1080

ggaatttgta catccaaatg aatattgtat agacaatttt cccaggaatg tgcaaaatgc     1140

ttgaaagttc aaacttcttt tttgaaatga tcttcagatc cagtggccca ttcttttatc     1200

tttatcctgt gaaggtgttt ttcaggtttt gaaacaatcc aaaaatcatt taggaccaag     1260

tctaaggaaa cattttagtg gccaagttgg attccgattg taaaggaatg atactaattt     1320

tctagcatgg ctctgaaggt gattttaggt agaagagttt tgaggctggg cgcaatggct     1380

cacgcctgta atcctagcat tttgggtgac tgaggcgggt ggattgcttg agcccagaag     1440

ttgaagacca gcctgagaaa taaggtgaaa ccctgtctac aaaaaataca aaaagttagc     1500

tgggtgtggt ggcgtgtgcc tgtagtgcta gctactcaga aggctgaggt gggaggattg     1560

tttgagccca ggaggttgag gctgcagtga gttctaattg cgccactgca ctccagcctg     1620

agcgacagag tgagacactg tcttaaaaaa aattaaaaat tgtaaaaaaa tgaaaaaaaa     1680

agttttgagc attatttgca tcattgggat acatatgtca cttcacaaga tgttcaattt     1740

gaaggaaata ccactcattc tctatgtcct gttgtctgta gtgtgcttca gtttttcata     1800

ttgagttgac ctaaatcctg gattcatgac aagaaaggag taagtactac tattcattgt     1860

tctatttgtt tataatctgt attataaaat tgcacataat taaaagcttt cccttgtctt     1920

ca                                                                    1922


<210> 1863
<211> 2354
<212> DNA
<213> Homo sapiens

<400> 1863
accctgatca gggagtatcg gctgcgggtg cgcaaggcgt ccaggagtga cctggggctg       60

tggagagcga cccgtggcct tgtgtttcag gtacggaggt tccggactgg acgggcgtca      120

ggaagtcaca gacttgtcct ctgatgtggc cccgcccgcc gccgcactaa tctcttcggc      180

gtcgtacccg tcggcccagc tcgacccgcc gcagccccgg ccccgaccgt ggacactggg      240

ggtccccgag ggcgctgcga cctcctcccg gagtttacca cctaggatga cttcagtgac      300

tagatcagag atcatagatg aaaaaggacc agtgatgtct aagactcatg atcatcaatt      360

ggaatcaagt ctcagtcctg tggaagtgtt tgctaaaaca tctgcctccc tggagatgaa      420

tcaaggcgtt tcagaggaaa gaattcacct tggctctagc cctaaaaaag ggggaaattg      480

tgatctcagc caccaggaaa gacttcagtc gaagtccctt catttgtctc ctcaagaaca      540

atctgccagt tatcaagaca ggaggcaatc ctggcggcga gcaagtatga aagaaacgaa      600

ccggcggaag tcgctgcatc ccattcacca gggcatcaca gagctcagcc ggtctatcag      660

tgtcgattta gcagaaagca aacggcttgg ctgtctcctg ctttccagtt tccagttctc      720

tattcagaaa cttgaacctt tcctaaggga cactaagggc ttcagtcttg aaagttttag      780

agccaaagca tcttctcttt ctgaagaatt gaaacatttt gcagacggac tggaaactga      840

tggaactcta caaaaatgtt ttgaagattc aaatggaaaa gcatcagatt tttctttgga      900

agcatctgtg gctgagatga aggaatacat aacaaagttt tctttagaac gtcagacttg      960

ggatcagctc ttgcttcact accagcagga ggctaaagag atattgtcca gaggatcaac     1020

tgaggccaaa attactgagg tcaaagtgga acctatgaca tatcttgggt cttctcagaa     1080

tgaagttctt aatacaaaac ctgactacca gaaaatatta cagaaccaga gcaaagtctt     1140

tgactgtatg gagttggtga tggatgaact gcaaggatca gtgaaacagc tgcaggcctt     1200

tatggatgaa agtacccagt gcttccagaa ggtgtcagta cagctcggaa agagaagcat     1260

gcaacaatta gatccctcac cagctcgaaa actgttgaag cttcagctac agaacccacc     1320

tgccatacat ggatctggat ctggatcttg tcagtgactt tatgagagtt tctgccacaa     1380

ggtgcccaag aggagaggaa tgggaagagt gccccagcac gtggtgactg cgtgatttct     1440

gctcgttgcc tttgaagata actggcagga ctgactgtag aacactttga cttttttcaa     1500

aaagtgatgg aatttgtaca tccaaatgaa tattgtatag acaattttcc caggaatgtg     1560

caaaatgctt gaaagttcaa acttcttttt tgaaatgatc ttcagatcca gtggcccatt     1620

cttttatctt tatcctgtga aggtgttttt caggttttga aacaatccaa aaatcattta     1680

ggaccaagtc taaggaaaca ttttagtggc caagttggat tccgattgta aaggaatgat     1740

actaattttc tagcatggct ctgaaggtga ttttaggtag aagagttttg aggctgggcg     1800

caatggctca cgcctgtaat cctagcattt tgggtgactg aggcgggtgg attgcttgag     1860

cccagaagtt gaagaccagc ctgagaaata aggtgaaacc ctgtctacaa aaaatacaaa     1920

aagttagctg ggtgtggtgg cgtgtgcctg tagtgctagc tactcagaag gctgaggtgg     1980

gaggattgtt tgagcccagg aggttgaggc tgcagtgagt tctaattgcg ccactgcact     2040

ccagcctgag cgacagagtg agacactgtc ttaaaaaaaa ttaaaaattg taaaaaaatg     2100

aaaaaaaaag ttttgagcat tatttgcatc attgggatac atatgtcact tcacaagatg     2160

ttcaatttga aggaaatacc actcattctc tatgtcctgt tgtctgtagt gtgcttcagt     2220

ttttcatatt gagttgacct aaatcctgga ttcatgacaa gaaaggagta agtactacta     2280

ttcattgttc tatttgttta taatctgtat tataaaattg cacataatta aaagctttcc     2340

cttgtcttca tcta                                                       2354


<210> 1864
<211> 2233
<212> DNA
<213> Homo sapiens

<400> 1864
tgcgcccttg gttggcggga gtttcggagg cggtgaccgt gacgtagaag gtggagaccg       60

cttcaccctg atcagggagt atcggctgcg ggtgcgcaag gcgtccagga gtgacctggg      120

gctgtggaga gcgacccgtg gccttgtgtt tcagagttta ccacctagga tgacttcagt      180

gactagatca gagatcatag atgaaaaagg accagtgatg tctaagactc atgatcatca      240

attggaatca agtctcagtc ctgtggaagt gtttgctaaa acatctgcct ccctggagat      300

gaatcaaggc gtttcagagg aaagaattca ccttggctct agccctaaaa aagggggaaa      360

ttgtgatctc agccaccagg aaagacttca gtcgaagtcc cttcatttgt ctcctcaaga      420

acaatctgcc agttatcaag acaggaggca atcctggcgg cgagcaagta tgaaagaaac      480

gaaccggcgg aagtcgctgc atcccattca ccagggcatc acagagctca gccggtctat      540

cagtgtcgat ttagcagaaa gcaaacggct tggctgtctc ctgctttcca gtttccagtt      600

ctctattcag aaacttgaac ctttcctaag ggacactaag ggcttcagtc ttgaaagttt      660

tagagccaaa gcatcttctc tttctgaaga attgaaacat tttgcagacg gactggaaac      720

tgatggaact ctacaaaaat gttttgaaga ttcaaatgga aaagcatcag atttttcttt      780

ggaagcatct gtggctgaga tgaaggaata cataacaaag ttttctttag aacgtcagac      840

ttgggatcag ctcttgcttc actaccagca ggaggctaaa gagatattgt ccagaggatc      900

aactgaggcc aaaattactg aggtcaaagt ggaacctatg acatatcttg ggtcttctca      960

gaatgaagtt cttaatacaa aacctgacta ccagaaaata ttacagaacc agagcaaagt     1020

ctttgactgt atggagttgg tgatggatga actgcaagga tcagtgaaac agctgcaggc     1080

ctttatggat gaaagtaccc agtgcttcca gaaggtgtca gtacagctcg gaaagagaag     1140

catgcaacaa ttagatccct caccagctcg aaaactgttg aagcttcagc tacagaaccc     1200

acctgccata catggatctg gatctggatc ttgtcagtga ctttatgaga gtttctgcca     1260

caaggtgccc aagaggagag gaatgggaag agtgccccag cacgtggtga ctgcgtgatt     1320

tctgctcgtt gcctttgaag ataactggca ggactgactg tagaacactt tgactttttt     1380

caaaaagtga tggaatttgt acatccaaat gaatattgta tagacaattt tcccaggaat     1440

gtgcaaaatg cttgaaagtt caaacttctt ttttgaaatg atcttcagat ccagtggccc     1500

attcttttat ctttatcctg tgaaggtgtt tttcaggttt tgaaacaatc caaaaatcat     1560

ttaggaccaa gtctaaggaa acattttagt ggccaagttg gattccgatt gtaaaggaat     1620

gatactaatt ttctagcatg gctctgaagg tgattttagg tagaagagtt ttgaggctgg     1680

gcgcaatggc tcacgcctgt aatcctagca ttttgggtga ctgaggcggg tggattgctt     1740

gagcccagaa gttgaagacc agcctgagaa ataaggtgaa accctgtcta caaaaaatac     1800

aaaaagttag ctgggtgtgg tggcgtgtgc ctgtagtgct agctactcag aaggctgagg     1860

tgggaggatt gtttgagccc aggaggttga ggctgcagtg agttctaatt gcgccactgc     1920

actccagcct gagcgacaga gtgagacact gtcttaaaaa aaattaaaaa ttgtaaaaaa     1980

atgaaaaaaa aagttttgag cattatttgc atcattggga tacatatgtc acttcacaag     2040

atgttcaatt tgaaggaaat accactcatt ctctatgtcc tgttgtctgt agtgtgcttc     2100

agtttttcat attgagttga cctaaatcct ggattcatga caagaaagga gtaagtacta     2160

ctattcattg ttctatttgt ttataatctg tattataaaa ttgcacataa ttaaaagctt     2220

tcccttgtct tca                                                        2233


<210> 1865
<211> 2012
<212> DNA
<213> Homo sapiens

<400> 1865
cgagtgttgg cggggactga gcctcctgct tgaggtagtt gtttttactc ccagtcccca       60

ggctcacgag ccccacgcgc gctcaatctg ccctcccgct tctcctcgcc actccgagtt      120

ctgcgccctc gagatccagc gcatccgcgg ggtgggcggg tcctggcggc tctttgccct      180

cttccaacat ggccgccgct gcctctgtga caggcagggt cacgtgggca gcctcgccta      240

tgaggtcgct ggggctcggc cggcgattgt cccttcccgg accccgtctc gatgcggtga      300

ctgccgctgt caacccgagc ctgagcgatc atggcaacgg gctcgggcgg ggaacgcgtg      360

gcagcggctg cagcggcggc agtttggtgg cggactgggg cggcggagcg gcggcggcgg      420

cggcggtggc actggcactg gccccggccc tgagcaccat gcggcggggc agctccgaga      480

gcgagctggc ggcccggtgg gaggcggagg cggtggctgc ggccaaagcg gcggccaaag      540

ctgaggccga ggccacagcg gagacggtgg cggaacaggt ccgcgtggac gcgggcgcgg      600

ccggggaacc ggagtgcaag gcaggggagg agcagcccaa ggtcctggcc ccggccccgg      660

cgcagcccag tgcggctgag gaggggaaca cccaggtcct tcagcggccg ccgcccacgc      720

tgcccccgtc caagccgaag ccggtgcagg gcctctgccc gcacgggaag ccccgggaca      780

agggccgaag ctgcaagcgg agctcgggcc acggttccgg cgagaacggc tcccagcggc      840

cggtcaccgt ggacagctcc aaggccagga cctccctgga tgccctgaag atcagcatcc      900

gccagctcaa gtggaaggag ttcccatttg gccggcgctt gccttgtgac atctactggc      960

atggagtttc atttcacgac aatgacatat tctccggtca agtgaacaag tttccaggca     1020

tgacggagat ggtgcgtaaa attactctga gcagagcagt gagaaccatg cagaatctct     1080

ttcctgagga gtacaacttc taccctcgct catggattct gcctgacgag ttccagctct     1140

ttgttgctca ggttcaaatg gtgaaagacg atgacccctc ctggaagccc acttttatcg     1200

tgaaacctga tggtggttgt cagggtgatg gaatctacct cattaaagac cccagtgaca     1260

tccgcctggc agggaccctc cagagcaggc cagcggtggt ccaggagtac atctgcaaac     1320

ctctccttat cgacaagctc aagtttgata ttcgtctgta tgtcttactc aagtccttag     1380

accccttaga gatttatata gccaaagacg gactctctag gttttgtacc gagccatatc     1440

aggagcccac ccccaaaaac ctgcaccgca tctttatgca cttaaccaac tattcactga     1500

acatccacag cggcaacttc atccactcgg acagtgctag cactggcagc aaaaggactt     1560

tttccagcat cctttgtaga ctgtcttcca aaggcgttga catcaagaag gtctggtctg     1620

acatcatctc cgtggtgatt aagacggtca tcgcgctgac tccagagctc aaagtcttct     1680

accagtcaga catccccacg gggaggccgg gccccacgtg cttccaggta accattgcca     1740

gttcccagcc tgcgtttcca gccttgaccg gcctcaagag ggctctctgg cttcgtgtag     1800

gatgagtgat cggggtggga tggccagagg aggggacagt gttggtggtg ctgtgggctt     1860

gggtgttaaa cctgggccca acttccaagc tttctgtttg ctccctgtgt gatttggggc     1920

aagctacttc ccctctgtta cctgtaaaat gaaatgaaga atacctatct taaaaggttc     1980

ttgtaagaat taaatgagat aacacatgta aa                                   2012


<210> 1866
<211> 2193
<212> DNA
<213> Homo sapiens

<400> 1866
ggagctcggg ccacggttcc ggcgagaacg gctcccagcg gccggtcacc gtggacagct       60

ccaaggccag gacctccctg gatgccctga agatcagcat ccgccagctc aagtggaagg      120

agttcccatt tggccggcgc ttgccttgtg acatctactg gcatggagtt tcatttcacg      180

acaatgacat attctccggt caagtgaaca agtttccagg catgacggag atggtgcgta      240

aaattactct gagcagagca gtgagaacca tgcagaatct ctttcctgag gagtacatct      300

gcaaacctct ccttatcgac aagctcaagt ttgatattcg tctgtatgtc ttactcaagt      360

ccttagaccc cttagagatt tatatagcca aagacggact ctctaggttt tgtaccgagc      420

catatcagga gcccaccccc aaaaacctgc accgcatctt tatgcactta accaactatt      480

cactgaacat ccacagcggc aacttcatcc actcggacag tgctagcact ggcagcaaaa      540

ggactttttc cagcatcctt tgtagactgt cttccaaagg cgttgacatc aagaaggtct      600

ggtctgacat catctccgtg gtgattaaga cggtcatcgc gctgactcca gagctcaaag      660

tcttctacca gtcagacatc cccacgggga ggccgggccc cacgtgcttc cagattttag      720

gctttgacat tcttctaatg aaaaatctga agcctatact acttgaagta aatgcaaatc      780

ccagtatgag aatcgaacat gagcacgaac tttctccagg ggtgtttgaa aatgtcccca      840

gcctcgttga tgaagaagtg aaagtggctg tgatcagaga cactctgcgc ctcatggacc      900

cacttaagaa gaaaagagag aatcagtctc agcagcttga aaaaccattc gctggaaagg      960

aagatgcttt ggacggcgag ctgaccagtg ctccagactg caacgccaac cccgaagccc     1020

acctgccttc catttgcctc aagcaggtgt tccccaagta cgcaaaacag ttcaactacc     1080

tgcgcctggt ggacaggatg gcaaatttgt ttatccggtt cctgggcatc aaggggacaa     1140

tgaagttggg gccaacaggc tttcgtacct tcataaggag ctgcaaactc agcagcagca     1200

gcctgtccat ggctgccgtg gacatcctct acattgacat cacacggagg tggaactcca     1260

tgaccctgga ccagcgggac tcagggatgt gtctgcaggc cttcgtagaa gctttctttt     1320

tcctggctca gaggaagttc aagatgctgc cacttcatga gcaggtggcc tcactgattg     1380

acctttgcga gtaccacctg tccctgctgg atgaaaaacg cctggtgtgt ggccggggcg     1440

tcccgtcggg gggccggccc ccacaccgtg gccctcccca ggagccctcc ccctcggccc     1500

agccagcagg ggacaacccc ccaccccgca ccagctgtgc caataagctc tcccatccca     1560

gacataccct gtcctgaggg ccactctgtc ctcctggaaa acggaagacg agagcagctt     1620

tcagggctgg agcgccccag gcattctgcc tgcagaggaa tggcaggcag gctgccgagg     1680

ggcccagctg aggtccccac gaactgtctc tgtgtgcggc tgagctgtgc ttcaccaggc     1740

tggctggttc tcacctgcct tcctcctcac acctcctggt gatacaccct gtttctgagt     1800

catcagtcat cggacatatg acatctaaaa cgtgacagat ggcaccttct attctgggct     1860

cacaggaagc accaactggg gcaaatctgt tgtatttggg gcacaggaca caatcgatcc     1920

caaggcccgg agctgtggag aggaagccga gtgttaggat ctgctgccgg ggcctccacg     1980

cgcccaccgg gaaaagcctg agaacatcgt gtttatttcc tgccgcccgt tccgagagaa     2040

ggaagtggaa atatcaagta ggcatctgcg aatctcccat cccagtcatg tgctacatgg     2100

gtgtagtgaa cagattaacc tcatttagtt cattagcttg cctgttgctg caatatttgg     2160

tttgttatta attaagaaaa aattaattaa gaa                                  2193


<210> 1867
<211> 4358
<212> DNA
<213> Homo sapiens

<400> 1867
tcgtggggcg ggggtggggc gggactgagg gcggagtgtg agcgggctcg gttttgggcc       60

gcggcgggag cgggagtcgc cgccactcga gtgcgcaggc gcctggcgat taccggtctc      120

accatggagc ggaaagtgct tgcgctccag gcccgaaaga aaaggaccaa ggccaagaag      180

gacaaagccc aaaggaaatc tgaaactcag caccgaggct ctgctcccca ctctgagagt      240

gatctaccag agcaggaaga ggagattctg ggatctgatg atgatgagca agaagatcct      300

aatgattatt gtaaaggagg ttatcatctt gtgaaaattg gagatctatt caatgggaga      360

taccatgtga tccgaaagtt aggctgggga cacttttcaa cagtatggtt atcatgggat      420

attcagggga agaaatttgt ggcaatgaaa gtagttaaaa gtgctgaaca ttacactgaa      480

acagcactag atgaaatccg gttgctgaag tcagttcgca attcagaccc taatgatcca      540

aatagagaaa tggttgttca actactagat gactttaaaa tatcaggagt taatggaaca      600

catatctgca tggtatttga agttttgggg catcatctgc tcaagtggat catcaaatcc      660

aattatcagg ggcttccact gccttgtgtc aaaaaaatta ttcagcaagt gttacagggt      720

cttgattatt tacataccaa gtgccgtatc atccacactg acattaaacc agagaacatc      780

ttattgtcag tgaatgagca gtacattcgg aggctggctg cagaagcaac agaatggcag      840

cgatctggag ctcctccgcc ttccggatct gcagtcagta ctgctcccca gcctaaacca      900

gctgacaaaa tgtcaaagaa taagaagaag aaattgaaga agaagcagaa gcgccaggca      960

gaattactag agaagcgaat gcaggaaatt gaggaaatgg agaaagagtc gggccctggg     1020

caaaaaagac caaacaagca agaagaatca gagagtcctg ttgaaagacc cttgaaagag     1080

aacccaccta ataaaatgac ccaagaaaaa cttgaagagt caagtaccat tggccaggat     1140

caaacgctta tggaacgtga tacagagggt ggtgcagcag aaattaattg caatggagtg     1200

attgaagtca ttaattatac tcagaacagt aataatgaaa cattgagaca taaagaggat     1260

ctacataatg ctaatgactg tgatgtccaa aatttgaatc aggaatctag tttcctaagc     1320

tcccaaaatg gagacagcag cacatctcaa gaaacagact cttgtacacc tataacatct     1380

gaggtgtcag acaccatggt gtgccagtct tcctcaactg taggtcagtc attcagtgaa     1440

caacacatta gccaacttca agaaagcatt cgggcagaga taccctgtga agatgaacaa     1500

gagcaagaac ataacggacc actggacaac aaaggaaaat ccacggctgg aaattttctt     1560

gttaatcccc ttgagccaaa aaatgcagaa aagctcaagg tgaagattgc tgaccttgga     1620

aatgcttgtt ggcacaaaca tttcactgaa gatattcaaa caaggcaata tcgttccttg     1680

gaagttctaa tcggatctgg ctataatacc cctgctgaca tttggagcac ggcatgcatg     1740

gcctttgaac tggccacagg tgactatttg tttgaacctc attcagggga agagtacact     1800

cgagatgaag accacattgt gcacattata gagctgatag gcagaattcc aagacgcttt     1860

tccctcagtg ggaaatattc acaagacttc ttcagtcaca gaggtgacct gaaacatatc     1920

acgaagctga aaccttgggg cctttttgag gttctagtgg agaagtatga gtggtcgcag     1980

gaagaggcag ctggcttcac agatttctta ctgcccatgt tggagctgat ccctgagaag     2040

agagccactg ccgccgagtg tctccggcac ccttggctta actcctaagc ccctgcccag     2100

caccacagca gagatcacac actgaccctc cgcccttccc cttcaagcat tttcctcttc     2160

ccttttcagg gtgaagctct tccttcaaga gtttctagat cttgtttttt ttttaatcca     2220

acatgttcat ttgggtttgc ttacttgacc ctgtggagat ccccacagcc attgggcatc     2280

ctaggtgaat ttggccttgg ttgggctctg ccaaagacta atggactaaa atgtgaaaca     2340

gcctcttgcc ctgtaccttt ccttcccatt aggacatcct ttaaattata agcatccttt     2400

ttgaaaagag ctatgaaggt gtatgagccc atccttttat tcattgactc taagagtcaa     2460

attttctagt gcatatccta ttgccagcat aaggatgagg agggggaaag ggtcttaatt     2520

ctatgtacag cagagacatt aaacttgctg tgtccgggct gcatcatctt cctggactgt     2580

ttctgttgtt ctctgtgttc acattttttc ctgcaacttt taagctactg tcttttttaa     2640

atagctatat gaacaccaaa tttgggtacc attttatcac tgttcaaagc actgtcaaat     2700

tcctttcatc ctttaatagt taagatcttt gaatcttcag tctgattttt aatgtaagca     2760

aaaacagaac cattgaatag taatttcttg agaacctcag gtgttctata aacagtcctt     2820

tcctgtatgt cttctattac cctaagacca gagttatttt ggttggttgt tttgttttat     2880

tttttgtttt tgtatccatg gctggcactt tactcattgc acttgagttt attgccccat     2940

aactaaagga tcaggatgat ggtagaacgg agatctgggt ttcagagctt tcccatttaa     3000

gaaaaataga tcttgagatt ctgattcttt tccaaacagt cccctgcttt catgtacagc     3060

tttttcttta ccttacccaa aattctggcc ttgaagcagt tttcctctat ggctttgcct     3120

ttctgatttt ctcagaggct cgagtcttta atataacccc aaatgaaaga accaagggga     3180

ggggtgggat ggcacttttt tttgttggtc ttgttttgtt ttgttttttg gttggttggt     3240

tcgttatttt ttaagattag ccattctctg ctgctatttc cctacataat gtcaattttt     3300

aaccataatt ttgacatgat tgagatgtac ttgaggcttt tttgttttaa ttgagaaaag     3360

actttgcaat ttttttttta ggatgagcct ctcctagact tgacctagaa tattacatat     3420

tcctccagta agtaatactg aagagcaaaa gagaggcagg attggggtca cagccgcttc     3480

ttcagcatgg accaagtggg ccttggggat tgcagcgttc tcgaagtggc tgtaggactc     3540

gaatttacag aaagccacag aggtgcaact tgaggctctg ctagcaagcc accagtgagg     3600

ctattgggta accacctttc tatacaggag attggaatct actttgtcat ttatccacca     3660

cagtgacaaa ggaaaagtgg tgccgttatg caatccattt aactcataaa catattactc     3720

tgagtaactg gccagccatt catcggatcc ttcattgggt actcctgaaa tcagacatgt     3780

tcctgtagaa agaattttaa gttaggcttt ctatgcacct atcaagaatc aagagaatag     3840

attgtatcaa acaacggcag ggaaatcctt cagcaattct aatccacttt gggttttcag     3900

ctgtttttac atctaaagca atagactaga actgaattat cttctacata gtaaaatcac     3960

aattgtggaa ttacaggaat tctggtgata ttaaggtgaa ataacaaaac acaaaaggcc     4020

ctattttaac agttgatgtg acagtaagtt ttaatagaac ctgtaacttc attttggaaa     4080

tgcttctcca ccaaataagg gctttttccc ctatttaagg agccagatgg attgaaagat     4140

gtggaaatag gcagctgtag atcttgatct tccaggtacc ccatgtacct ttattgagct     4200

taattataat actgtcaaat tgccacgatc tcactaaagg atttctattt gctgtcagtt     4260

aaaaataaag ccctaaatac atttttattc tttctactga gggcattgtc tgttttcttt     4320

gtaaatgccg tacaataaac aaattattta ataaccta                             4358


<210> 1868
<211> 4592
<212> DNA
<213> Homo sapiens

<400> 1868
aaatagaaca aaactaacct tgccaggttt ccaagcttgg atctctaaca ctccttcaac       60

gttcaccccg gcgttcctcc ccgctgcgcc ccctccctct ccttgccgcc ccctcctcgg      120

gagcaggtgg taggctccgc gcccaacgcg caagcgcgcg gcatcgtggg gcgggggtgg      180

ggcgggactg agggcggagt gtgagcgggc tcggttttgg gccgcggcgg gagcgggagt      240

cgccgccact cgagtgcgca ggcgcctggc gattaccggt ctcaccatgg agcggaaagt      300

gcttgcgctc caggcccgaa agaaaaggac caaggccaag aaggacaaag cccaaaggaa      360

atctgaaact cagcaccgag gctctgctcc ccactctgag agtgatctac cagagcagga      420

agaggagatt ctgggatctg atgatgatga gcaagaagat cctaatgatt attgtaaagg      480

aggttatcat cttgtgaaaa ttggagatct attcaatggg agataccatg tgatccgaaa      540

gttaggctgg ggacactttt caacagtatg gttatcatgg gatattcagg ggaagaaatt      600

tgtggcaatg aaagtagtta aaagtgctga acattacact gaaacagcac tagatgaaat      660

ccggttgctg aagtcagttc gcaattcaga ccctaatgat ccaaatagag aaatggttgt      720

tcaactacta gatgacttta aaatatcagg agttaatgga acacatatct gcatggtatt      780

tgaagttttg gggcatcatc tgctcaagtg gatcatcaaa tccaattatc aggggcttcc      840

actgccttgt gtcaaaaaaa ttattcagca agtgttacag ggtcttgatt atttacatac      900

caagtgccgt atcatccaca ctgacattaa accagagaac atcttattgt cagtgaatga      960

gcagtacatt cggaggctgg ctgcagaagc aacagaatgg cagcgatctg gagctcctcc     1020

gccttccgga tctgcagtca gtactgctcc ccagcctaaa ccagctgaca aaatgtcaaa     1080

gaataagaag aagaaattga agaagaagca gaagcgccag gcagaattac tagagaagcg     1140

aatgcaggaa attgaggaaa tggagaaaga gtcgggccct gggcaaaaaa gaccaaacaa     1200

gcaagaagaa tcagagagtc ctgttgaaag acccttgaaa gagaacccac ctaataaaat     1260

gacccaagaa aaacttgaag agtcaagtac cattggccag gatcaaacgc ttatggaacg     1320

tgatacagag ggtggtgcag cagaaattaa ttgcaatgga gtgattgaag tcattaatta     1380

tactcagaac agtaataatg aaacattgag acataaagag gatctacata atgctaatga     1440

ctgtgatgtc caaaatttga atcaggaatc tagtttccta agctcccaaa atggagacag     1500

cagcacatct caagaaacag actcttgtac acctataaca tctgaggtgt cagacaccat     1560

ggtgtgccag tcttcctcaa ctgtaggtca gtcattcagt gaacaacaca ttagccaact     1620

tcaagaaagc attcgggcag agataccctg tgaagatgaa caagagcaag aacataacgg     1680

accactggac aacaaaggaa aatccacggc tggaaatttt cttgttaatc cccttgagcc     1740

aaaaaatgca gaaaagctca aggtgaagat tgctgacctt ggaaatgctt gttgggtgca     1800

caaacatttc actgaagata ttcaaacaag gcaatatcgt tccttggaag ttctaatcgg     1860

atctggctat aatacccctg ctgacatttg gagcacggca tgcatggcct ttgaactggc     1920

cacaggtgac tatttgtttg aacctcattc aggggaagag tacactcgag atgaagatca     1980

cattgcattg atcatagaac ttctggggaa ggtgcctcgc aagctcattg tggcaggaaa     2040

atattccaag gaatttttca ccaaaaaagg tgacctgaaa catatcacga agctgaaacc     2100

ttggggcctt tttgaggttc tagtggagaa gtatgagtgg tcgcaggaag aggcagctgg     2160

cttcacagat ttcttactgc ccatgttgga gctgatccct gagaagagag ccactgccgc     2220

cgagtgtctc cggcaccctt ggcttaactc ctaagcccct gcccagcacc acagcagaga     2280

tcacacactg accctccgcc cttccccttc aagcattttc ctcttccctt ttcagggtga     2340

agctcttcct tcaagagttt ctagatcttg tttttttttt aatccaacat gttcatttgg     2400

gtttgcttac ttgaccctgt ggagatcccc acagccattg ggcatcctag gtgaatttgg     2460

ccttggttgg gctctgccaa agactaatgg actaaaatgt gaaacagcct cttgccctgt     2520

acctttcctt cccattagga catcctttaa attataagca tcctttttga aaagagctat     2580

gaaggtgtat gagcccatcc ttttattcat tgactctaag agtcaaattt tctagtgcat     2640

atcctattgc cagcataagg atgaggaggg ggaaagggtc ttaattctat gtacagcaga     2700

gacattaaac ttgctgtgtc cgggctgcat catcttcctg gactgtttct gttgttctct     2760

gtgttcacat tttttcctgc aacttttaag ctactgtctt ttttaaatag ctatatgaac     2820

accaaatttg ggtaccattt tatcactgtt caaagcactg tcaaattcct ttcatccttt     2880

aatagttaag atctttgaat cttcagtctg atttttaatg taagcaaaaa cagaaccatt     2940

gaatagtaat ttcttgagaa cctcaggtgt tctataaaca gtcctttcct gtatgtcttc     3000

tattacccta agaccagagt tattttggtt ggttgttttg ttttattttt tgtttttgta     3060

tccatggctg gcactttact cattgcactt gagtttattg ccccataact aaaggatcag     3120

gatgatggta gaacggagat ctgggtttca gagctttccc atttaagaaa aatagatctt     3180

gagattctga ttcttttcca aacagtcccc tgctttcatg tacagctttt tctttacctt     3240

acccaaaatt ctggccttga agcagttttc ctctatggct ttgcctttct gattttctca     3300

gaggctcgag tctttaatat aaccccaaat gaaagaacca aggggagggg tgggatggca     3360

cttttttttg ttggtcttgt tttgttttgt tttttggttg gttggttcgt tattttttaa     3420

gattagccat tctctgctgc tatttcccta cataatgtca atttttaacc ataattttga     3480

catgattgag atgtacttga ggcttttttg ttttaattga gaaaagactt tgcaattttt     3540

tttttaggat gagcctctcc tagacttgac ctagaatatt acatattcct ccagtaagta     3600

atactgaaga gcaaaagaga ggcaggattg gggtcacagc cgcttcttca gcatggacca     3660

agtgggcctt ggggattgca gcgttctcga agtggctgta ggactcgaat ttacagaaag     3720

ccacagaggt gcaacttgag gctctgctag caagccacca gtgaggctat tgggtaacca     3780

cctttctata caggagattg gaatctactt tgtcatttat ccaccacagt gacaaaggaa     3840

aagtggtgcc gttatgcaat ccatttaact cataaacata ttactctgag taactggcca     3900

gccattcatc ggatccttca ttgggtactc ctgaaatcag acatgttcct gtagaaagaa     3960

ttttaagtta ggctttctat gcacctatca agaatcaaga gaatagattg tatcaaacaa     4020

cggcagggaa atccttcagc aattctaatc cactttgggt tttcagctgt ttttacatct     4080

aaagcaatag actagaactg aattatcttc tacatagtaa aatcacaatt gtggaattac     4140

aggaattctg gtgatattaa ggtgaaataa caaaacacaa aaggccctat tttaacagtt     4200

gatgtgacag taagttttaa tagaacctgt aacttcattt tggaaatgct tctccaccaa     4260

ataagggctt tttcccctat ttaaggagcc agatggattg aaagatgtgg aaataggcag     4320

ctgtagatct tgatcttcca ggtaccccat gtacctttat tgagcttaat tataatactg     4380

tcaaattgcc acgatctcac taaaggattt ctatttgctg tcagttaaaa ataaagccct     4440

aaatacattt ttattctttc tactgagggc attgtctgtt ttctttgtaa atgccgtaca     4500

ataaacaaat tatttaataa cctacatgtt tccaaaaatc tctgttcatt tgttgtccaa     4560

attgctctgc cctgagtaaa aggaggaaaa ga                                   4592


<210> 1869
<211> 1793
<212> DNA
<213> Homo sapiens

<400> 1869
gcaaagcccc accccggtgc gcgggtatgg cggccagcct gtggatgggc gacctggaac       60

cctacatgga tgagaacttc atctccagag cctttgccac catgggggag accgtaatga      120

gcgtcaaaat tatccgaaac cgcctcactg ggatcccagc tggctactgc tttgtagaat      180

ttgcagattt ggccacagct gagaagtgtt tgcataaaat taatgggaaa ccccttccag      240

gagccacacc tgcgaaacgt tttaaactga actatgccac ttacgggaaa caaccagata      300

acagccctga gtattccctc tttgtggggg acctgacccc ggacgtggat gatggcatgc      360

tgtatgaatt cttcgtcaaa gtctacccct cctgtcgggg aggcaaggtg gttttggacc      420

agacaggcgt gtctaagggt tatggttttg tgaaattcac agatgaactg gaacagaagc      480

gagccctgac ggagtgccag ggagcagtgg gactggggtc taagcctgtg cggctgagcg      540

tggcaatccc taaagcgagc cgtgtaaagc cagtggaata tagtcagatg tacagttata      600

gctacaacca gtattatcag cagtaccaga actactatgc tcagtggggc tatgaccaga      660

acacaggcag ctacagctac agttaccccc agtatggcta tacccagagc accatgcaga      720

catatgaaga agttggagat gatgcattgg aagaccccat gccacagctg gatgtgactg      780

aggccaacaa ggagttcatg gaacagagtg aggagctgta tgacgctctg atggactgtc      840

actggcagcc cctggacaca gtgtcttcag agatccctgc catgatgtag ccaggccaaa      900

ggacaagcca ggttgcatga tgtgagggag atgagagact cctttttaaa aattgtgaaa      960

cctttttgga aatatgattt gtaagatttt aataatgact gtttttggag atcatgaatg     1020

tttctacaac actgctgcat tcatttgacc atttgagttt gaagaccaag ggaacaactt     1080

ttaaacaagg ttcaaattgg tttccttcac aggaatcctt tgtccaggta gttatccaca     1140

taggacagtt tgggattatc caaaactggg atgagcagct tgggataatt cacacactaa     1200

agcctgagtt caaggtttct cagttgacag gtaggtatgt aaatcagggt tctctggagt     1260

atttgtagga cctgccatat ttgagtccta acttggtgca agtctggcag ctaggtagaa     1320

aaggcactct agcaggtgtg gtaggagcac gccccagaag gtagaatgtg gtggggtgtg     1380

atggaacagg ccagttggcc taagaattag tacttgctct aataatgggt ttcatctatt     1440

ttcatgagtt gcagcatctg catatacaag gcctggatca ctttaggatc aatattttga     1500

cacgggagaa ggcagctcag aaaggattaa ggaagatagc tcaaagccaa agcagaccct     1560

ccgtgtgaac tttatactgc tcacttccgt gtttcccaag taaatgggga aactgtccaa     1620

ccttgtcatg tgttgggact tactgcttga ggcaaagcat tcatcctaca tcataaaaaa     1680

tctccaaaga tctctttaag ggctgggcat ggtggctcac tttgggagat ggattgcttg     1740

agctcgggaa gagaccagtt cggtctctac aaaaaaatac aaacacaaat ata            1793


<210> 1870
<211> 713
<212> DNA
<213> Homo sapiens

<400> 1870
caatgtttaa gcaagaagaa ggaaaaactg acagaagagc ttcagaaact acagaaagac       60

atagagatgg cagaacgcaa tgaggatcac cacctgcagg tccttaaaga atctgaggtg      120

cttcttcagg ccaaaagagc cgagctggaa aagctgaaaa gccaggtgac aagtcagcag      180

caggagatgg ctgtcttgga caggcagtta gggcataaaa aggaggagct gcatctactc      240

caaggaagca tggtccaggc aaaagctgac ctccaggaag ctctgagact gggagagact      300

gaagtaactg agaagtgcaa tcacattagg gaagtaaaat ctcttctgga agaactgagt      360

tttcagaaag gagaactaaa tgttcagatt agtgaaagaa aaactcaact tacacttata      420

aagcaggaaa ttgaaaaaga ggaagaaaat cttcaggttg ttttaaggca gatgtctaaa      480

cataaaaccg cttttctaca gtaagcaagt atctctatga tcagaaaaaa agttaatatt      540

taaatatctg tatttcaaag gccaaaaaat tgttatataa atctcagtct gtatttcaaa      600

gtatttttaa tttattttga tcaattttat ataaaatgct tttagttgat tcttttatgt      660

agaagcaaat gctttggaac cagatctttg ttaattaaat gtttttgtta aaa             713


<210> 1871
<211> 3920
<212> DNA
<213> Homo sapiens

<400> 1871
cacttttata cttcccttcg tttgcatgtg ttacttcttc agcctaggtc tttccccttc       60

cgttcgttct tcaaaaccca ggcaaaacac ctcttcctct gagcagcctt ctcagaactt      120

ttctcccatg tggccagagg aaggagagac ttctgtctat ctcttctgct agaccccgaa      180

ctctttggag gcagaggtta tccacaagag gcttggcaaa tgtttctcag tcatagttgg      240

actgtttgaa aaattaaagg ttctatttgt ctgtcagttt catccgtgac atttaacttt      300

ttataccaaa gtcttagaat ctaccatcat tttttgggcc attgatacca ctttaaccac      360

agttaatttc agcttttggc aggaaagaga ggaaacatcc tgtgatgttt cagcactgca      420

tttttttccc catctcattc aggagaatga agtttctaga ttagaagaca taatgcagca      480

tttaaaatca aagaagcggg aagaaaggtg gatgagagca tccaagcggc agtcggagaa      540

agaaatggaa gaactgcatc ataatattga tgatcttttg caagagaaga aaagcttaga      600

gtgtgaagta gaagaattac atagaactgt ccagaaacgt caacagcaaa aggacttcat      660

tgatggaaat gttgagagtc ttatgactga actagaaata gaaaaatcac tcaaacatca      720

tgaagatatt gtagatgaaa ttgagtgcat tgagaagact cttctgaaac gtcgctcaga      780

gctcagggaa gctgaccgac tcctggcaga ggctgagagt gaactttcat gcactaaaga      840

aaaggtttgt cttcttgtgg tttggggtgt gagctcagtg tggacaaaaa atgctgttga      900

aaagttcact gatgccaaga gaagtttatt gcaaactgag tcagatgctg aggaattaga      960

aaggagagct caggaaactg ctgttaacct cgtcaaagct gatcagcagc taagatcgct     1020

ccaggctgat gcaaaggatt tggagcagca caaaatcaag caagaagaaa tcttgaaaga     1080

aataaacaaa attgtagcag caaaagactc agacttccaa tgtttaagca agaagaagga     1140

aaaactgaca gaagagcttc agaaactaca gaaagacata gagatggcag aacgcaatga     1200

ggatcaccac ctgcaggtcc ttaaagaatc tgaggtgctt cttcaggcca aaagagccga     1260

gctggaaaag ctgaaaagcc aggtgacaag tcagcagcag gagatggctg tcttggacag     1320

gcagttaggg cataaaaagg aggagctgca tctactccaa ggaagcatgg tccaggcaaa     1380

agctgacctc caggaagctc tgagactggg agagactgaa gtaactgaga agtgcaatca     1440

cattagggaa gtaaaatctc ttctggaaga actgagtttt cagaaaggag aactaaatgt     1500

tcagattagt gaaagaaaaa ctcaacttac acttataaag caggaaattg aaaaagagga     1560

agaaaatctt caggttgttt taaggcagat gtctaaacat aaaaccgaac taaagaatat     1620

tctggacatg ttgcaacttg aaaaccatga gctacaaggt ttgaagctac aacatgacca     1680

aagggtatct gaattagaga agactcaggt ggcagtgcta gaggagaaac tggagttaga     1740

gaatttgcag cagatatccc agcagcagaa aggggaaata gagtggcaga agcagctcct     1800

tgagagggat aaacgagaaa tagaacgaat gactgctgag tcccgagctt tacaatcgtg     1860

tgttgagtgt ttgagcaaag aaaaggaaga tctccaagag aaatgtgaca tttgggaaaa     1920

aaagttggca caaaccaaaa gggttttagc agcagcagaa gaaaatagca aaatggagca     1980

atcaaactta gaaaagttgg aattgaatgt cagaaaactg cagcaggaac tagaccaact     2040

aaacagagac aagttgtcac tgcataacga catttcagca atgcaacagc agctccaaga     2100

aaaacgagaa gcagtaaact cactgcagga ggaactagct aatgtccaag accatttgaa     2160

cctagcaaaa caggacctgc ttcacaccac caagcatcag gatgtgttgc tcagtgagca     2220

gacccgactc cagaaggaca tcagtgaatg ggcaaatagg tttgaagact gtcagaaaga     2280

agaggagaca aaacaacaac aacttcaagt gcttcagaat gagattgaag aaaacaagct     2340

caaactagtc caacaagaaa tgatgtttca gagactccag aaagagagag aaagtgaaga     2400

aagcaaatta gaaaccagta aagtgacact gaaggagcaa cagcaccagc tggaaaagga     2460

attaacagac cagaaaagca aactggacca agtgctctca aaggtgctgg cagctgaaga     2520

gcgtgttagg actctgcagg aagaggagag gtggtgtgag agcctggaga agacactctc     2580

ccaaactaaa cggcagcttt cagaaaggga gcagcaattg gtggagaaat caggtgagct     2640

gttggccctc cagaaagagg cagattctat gagggcagac ttcagccttc tgcggaacca     2700

gttcttgaca gaaagaaaga aagctgagaa gcaggtggcc agcctgaagg aagcacttaa     2760

gatccagcgg agccagctgg agaaaaacct tcttgagcaa aaacaggaga acagctgcat     2820

acaaaaggaa atggcaacaa ttgaactggt agcccaggac aaccatgagc gggccaggcg     2880

cctgatgaag gagctcaacc agatgcagta tgagtacacg gagctcaaga aacagatggc     2940

aaaccaaaaa gatttggaga gaagacaaat ggaaatcagt gatgcaatga ggacacttaa     3000

atctgaggtg aaggatgaaa tcagaaccag cttgaagaat cttaatcagt ttcttccaga     3060

actaccagca gatctagaag ctattttgga aagaaacgaa aacctagaag gagaattgga     3120

aagcttgaaa gagaaccttc catttaccat gaatgaggga ccttttgaag aaaaactgaa     3180

cttttcccaa gttcacataa tggatgaaca ctggcgtgga gaagcactcc gggagaaact     3240

gcgtcaccgg gaagaccgac tcaaggccca actccgacac tgtatgtcca agcaagcaga     3300

agtattaatt aaaggaaagc ggcagacaga gggcacttta cacagtttga ggagacaagt     3360

agatgcttta ggggaattgg tcaccagcac ctctgcagat tcagcgtcat cacccagtct     3420

gtctcagctg gagtcttccc tcacagagga ctctcaactt ggacaaaatc aggaaaagaa     3480

tgcctcagcc agatgaggaa tactgtcttg tgtaaatata ttcaaggaaa acacctccac     3540

tacctcactg acttcataat tggaatgtca catggttttt ttaatcaaga tgcagtgaac     3600

tgagattctg aaactccact gtagtttact ttgcctgtac cattaatgcc aatgttttta     3660

taaatcactt gtacatagta catatgggaa tagttgcata tgggaattta aaccaacatg     3720

tggctgagcc tttttttttt taatcttcgt aacatgttta aaaaaaaaca gtgattttaa     3780

ctgcatattt gaacctacaa actggtaaat cttattaaca aaaagaatgt acttaaggcc     3840

ctctttattt atagtgtcga gttatttttg aattttgctt aaaatctatt tttcatatga     3900

aaataaaaga taacaatcaa                                                 3920


<210> 1872
<211> 3372
<212> DNA
<213> Homo sapiens

<400> 1872
gcgaagttac agaggctcgg aggcgcttgc aaaaatgtgg ctgtcagaga gggaagtgca       60

catgaatttg aagacagcat tagaaagcgt tccgcccaca gtttctctgt tctcaacggc      120

tcagttttaa caggataaat tttaagttaa gtcccatatg aaggctcaaa agagcggtaa      180

agaacaacag cttgacatta tgaacaagca gtaccaacaa cttgaaagtc gtttggatga      240

gatactttct agaattgcta aggaaacgga agagattaag gaccttgaag aacagcttac      300

tgaaggccag atagcagcaa atgaagccct gaagaaggat ttagaaggtg ttatcagtgg      360

gttgcaagaa tacctgggga ccattaaagg ccaggcaact caggcccaga atgagtgcag      420

gaagctgcgg gatgagaaag agacattgtt gcagagattg acagaagtcg agcaggagag      480

agaccagctg gaaatagttg ccatggatgc agaaaatatg aggaaggagc ttgcagagct      540

agaaagtgcc ctccaagagc agcatgaggt gaatgcatct ttgcagcaga cccagggaga      600

tctcagtgcc tatgaagctg agctagaggc tcggctaaac ctaagggatg ctgaagccaa      660

ccagctcaag gaagagttgg aaaaagtaac aagacttacc cagttagaac aatcagccct      720

tcaagcagaa cttgagaagg aaaggcaagc cctcaagaat gcccttggaa aagcccagtt      780

ctcagaagaa aaggagcaag agaacagtga gctccatgca aaacttaaac acttgcagga      840

tgacaataat ctgttaaaac agcaacttaa agatttccag aatcacctta accatgtggt      900

tgatggtttg gttcgtccag aagaagtggc agctcgtgtg gatgagctaa gaagaaaact      960

gaaattagga actggggaaa tgaacatcca tagtccttca gatgtcttag ggaaaagtct     1020

tgctgattta cagaaacaat tcagtgaaat tcttgcacgc tccaagtggg aaagagatga     1080

agcacaagtt agagagagaa aactccaaga agaaatggct ctgcagcaag agaaactggc     1140

aactggacaa gaagagttca ggcaggcctg tgagagagcc ctggaagcaa gaatgaattt     1200

tgataagagg caacatgaag caagaatcca gcaaatggag aatgaaattc actatttgca     1260

agaaaatcta aaaagtatgg aggaaatcca aggccttaca gatctccaac ttcaggaagc     1320

tgatgaagag aaggagagaa ttctggccca actccgagag ttagagaaaa agaagaaact     1380

tgaagatgcc aaatctcagg agcaagtttt tggtttagat aaagaactga agaaactaaa     1440

gaaagccgtg gccacctctg ataagctagc cacagctgag ctcaccattg ccaaagacca     1500

gctgaagtcc cttcatggaa ctgttatgaa aattaaccag gagcgagcag aggagttgca     1560

ggaagcagag aggttcagca gaaaggcagc acaagcagcc agagatctca cccgagcaga     1620

agctgagatc gaactcctgc agaatctcct caggcagaag ggggagcagt ttcgacttga     1680

gatggagaaa acaggtgtag gtactggagc aaactcacag gtcctagaaa ttgagaaact     1740

gaatgagaca atggaacgac aaaggacaga gattgcaagg ctgcagaatg tactagacct     1800

cactggaagt gacaacaaag gaggctttga aaatgtttta gaagaaattg ctgaacttcg     1860

acgtgaagtt tcttatcaga atgattacat aagcagcatg gcagatcctt tcaaaagacg     1920

aggctattgg tactttatgc caccaccacc atcatcaaaa gtttccagcc atagttccca     1980

ggccaccaag gactctggtg ttggccttaa gtactcagcc tcaactcctg ttagaaaacc     2040

acgccctggg cagcaggatg ggaaggaagg cagtcaacct ccccctgcct caggatactg     2100

ggtttattct cccatcagga gtgggttaca taaactgttt ccaagtagag atgcagacag     2160

tggaggagat agtcaggaag agagtgagct ggatgaccaa gaagaacccc catttgtgcc     2220

tcctcctgga tacatgatgt atactgtgct tcctgatggt tctcctgtac cccagggcat     2280

ggccctgtat gcaccacctc ctcccttgcc aaacaatagc cgacctctca cccctggcac     2340

tgttgtttat ggcccacctc ctgctggggc ccccatggtg tatgggcctc caccccccaa     2400

cttctccatc cccttcatcc ctatgggtgt gctgcattgc aacgtccctg aacaccataa     2460

cttagagaat gaagtttcta gattagaaga cataatgcag catttaaaat caaagaagcg     2520

ggaagaaagg tggatgagag catccaagcg gcagtcggag aaagaaatgg aagaactgca     2580

tcataatatt gatgatcttt tgcaagagaa gaaaagctta gagtgtgaag tagaagaatt     2640

acatagaact gtccagaaac gtcaacagca aaaggacttc attgatggaa atgttgagag     2700

tcttatgact gaactagaaa tagaaaaatc actcaaacat catgaagata ttgtagatga     2760

aattgagtgc attgagaaga ctcttctgaa acgtcgctca gagctcaggg aagctgaccg     2820

actcctggca gaggctgaga gtgaactttc atgcactaaa gaaaagacaa aaaatgctgt     2880

tgaaaagttc actgatgcca agagaagttt attgcaaact gagtcagatg ctgaggaatt     2940

agaaaggaga gctcaggaaa ctgctgttaa cctcgtcaaa gctgatcagc agctaagatc     3000

gctccaggct gatgcaaagg atttggagca gcacaaaatc aagcaagaag aaatcttgaa     3060

agaaataaac aaaattgtag cagcaaaaga ctcagacttc caatgtttaa gcaagaagaa     3120

ggaaaaactg acagaagagt aagtaaggcc tctgtagggc tacaaggggt ttgtgctgga     3180

agacagctct ggggttccga gtcccttagg atctgctcta gtgttgctgg tgctttgtag     3240

gcttcagaaa ctacagaaag acatagagat ggcagaacgc aatgaggatc accacctgca     3300

ggtccttaaa gaatctgagg tgcttcttca ggccaaaaga gccgagctgg aaaagctgaa     3360

aagccaggta tg                                                         3372


<210> 1873
<211> 5824
<212> DNA
<213> Homo sapiens

<400> 1873
gccggaaagc agaaggagat taaggacctg caaatagcca tagatagcct ggattccaaa       60

gacccaaaac attcccatat gaaggctcaa aagagcggta aagaacaaca gcttgacatt      120

atgaacaagc agtaccaaca acttgaaagt cgtttggatg agatactttc tagaattgct      180

aaggaaacgg aagagattaa ggaccttgaa gaacagctta ctgaaggcca gatagcagca      240

aatgaagccc tgaagaagga tttagaaggt gttatcagtg ggttgcaaga atacctgggg      300

accattaaag gccaggcaac tcaggcccag aatgagtgca ggaagctgcg ggatgagaaa      360

gagacattgt tgcagagatt gacagaagtc gagcaggaga gagaccagct ggaaatagtt      420

gccatggatg cagaaaatat gaggaaggag cttgcagagc tagaaagtgc cctccaagag      480

cagcatgagg tgaatgcatc tttgcagcag acccagggag atctcagtgc ctatgaagct      540

gagctagagg ctcggctaaa cctaagggat gctgaagcca accagctcaa ggaagagttg      600

gaaaaagtaa caagacttac ccagttagaa caatcagccc ttcaagcaga acttgagaag      660

gaaaggcaag ccctcaagaa tgcccttgga aaagcccagt tctcagaaga aaaggagcaa      720

gagaacagtg agctccatgc aaaacttaaa cacttgcagg atgacaataa tctgttaaaa      780

cagcaactta aagatttcca gaatcacctt aaccatgtgg ttgatggttt ggttcgtcca      840

gaagaagtgg cagctcgtgt ggatgagcta agaagaaaac tgaaattagg aactggggaa      900

atgaacatcc atagtccttc agatgtctta gggaaaagtc ttgctgattt acagaaacaa      960

ttcagtgaaa ttcttgcacg ctccaagtgg gaaagagatg aagcacaagt tagagagaga     1020

aaactccaag aagaaatggc tctgcagcaa gagaaactgg caactggaca agaagagttc     1080

aggcaggcct gtgagagagc cctggaagca agaatgaatt ttgataagag gcaacatgaa     1140

gcaagaatcc agcaaatgga gaatgaaatt cactatttgc aagaaaatct aaaaagtatg     1200

gaggaaatcc aaggccttac agatctccaa cttcaggaag ctgatgaaga gaaggagaga     1260

attctggccc aactccgaga gttagagaaa aagaagaaac ttgaagatgc caaatctcag     1320

gagcaagttt ttggtttaga taaagaactg aagaaactaa agaaagccgt ggccacctct     1380

gataagctag ccacagctga gctcaccatt gccaaagacc agctgaagtc ccttcatgga     1440

actgttatga aaattaacca ggagcgagca gaggagttgc aggaagcaga gaggttcagc     1500

agaaaggcag cacaagcagc cagagatctc acccgagcag aagctgagat cgaactcctg     1560

cagaatctcc tcaggcagaa gggggagcag tttcgacttg agatggagaa aacaggtgta     1620

ggtactggag caaactcaca ggtcctagaa attgagaaac tgaatgagac aatggaacga     1680

caaaggacag agattgcaag gctgcagaat gtactagacc tcactggaag tgacaacaaa     1740

ggaggctttg aaaatgtttt agaagaaatt gctgaacttc gacgtgaagt ttcttatcag     1800

aatgattaca taagcagcat ggcagatcct ttcaaaagac gaggctattg gtactttatg     1860

ccaccaccac catcatcaaa agtttccagc catagttccc aggccaccaa ggactctggt     1920

gttggcctta agtactcagc ctcaactcct gttagaaaac cacgccctgg gcagcaggat     1980

gggaaggaag gcagtcaacc tccccctgcc tcaggatact gggtttattc tcccatcagg     2040

agtgggttac ataaactgtt tccaagtaga gatgcagaca gtggaggaga tagtcaggaa     2100

gagagtgagc tggatgacca agaagaaccc ccatttgtgc ctcctcctgg atacatgatg     2160

tatactgtgc ttcctgatgg ttctcctgta ccccagggca tggccctgta tgcaccacct     2220

cctcccttgc caaacaatag ccgacctctc acccctggca ctgttgttta tggcccacct     2280

cctgctgggg cccccatggt gtatgggcct ccacccccca acttctccat ccccttcatc     2340

cctatgggtg tgctgcattg caacgtccct gaacaccata acttagagaa tgaagtttct     2400

agattagaag acataatgca gcatttaaaa tcaaagaagc gggaagaaag gtggatgaga     2460

gcatccaagc ggcagtcgga gaaagaaatg gaagaactgc atcataatat tgatgatctt     2520

ttgcaagaga agaaaagctt agagtgtgaa gtagaagaat tacatagaac tgtccagaaa     2580

cgtcaacagc aaaaggactt cattgatgga aatgttgaga gtcttatgac tgaactagaa     2640

atagaaaaat cactcaaaca tcatgaagat attgtagatg aaattgagtg cattgagaag     2700

actcttctga aacgtcgctc agagctcagg gaagctgacc gactcctggc agaggctgag     2760

agtgaacttt catgcactaa agaaaagaca aaaaatgctg ttgaaaagtt cactgatgcc     2820

aagagaagtt tattgcaaac tgagtcagat gctgaggaat tagaaaggag agctcaggaa     2880

actgctgtta acctcgtcaa agctgatcag cagctaagat cgctccaggc tgatgcaaag     2940

gatttggagc agcacaaaat caagcaagaa gaaatcttga aagaaataaa caaaattgta     3000

gcagcaaaag actcagactt ccaatgttta agcaagaaga aggaaaaact gacagaagag     3060

cttcagaaac tacagaaaga catagagatg gcagaacgca atgaggatca ccacctgcag     3120

gtccttaaag aatctgaggt gcttcttcag gccaaaagag ccgagctgga aaagctgaaa     3180

agccaggtga caagtcagca gcaggagatg gctgtcttgg acaggcagtt agggcataaa     3240

aaggaggagc tgcatctact ccaaggaagc atggtccagg caaaagctga cctccaggaa     3300

gctctgagac tgggagagac tgaagtaact gagaagtgca atcacattag ggaagtaaaa     3360

tctcttctgg aagaactgag ttttcagaaa ggagaactaa atgttcagat tagtgaaaga     3420

aaaactcaac ttacacttat aaagcaggaa attgaaaaag aggaagaaaa tcttcaggtt     3480

gttttaaggc agatgtctaa acataaaacc gaactaaaga atattctgga catgttgcaa     3540

cttgaaaacc atgagctaca aggtttgaag ctacaacatg accaaagggt atctgaatta     3600

gagaagactc aggtggcagt gctagaggag aaactggagt tagagaattt gcagcagata     3660

tcccagcagc agaaagggga aatagagtgg cagaagcagc tccttgagag ggataaacga     3720

gaaatagaac gaatgactgc tgagtcccga gctttacaat cgtgtgttga gtgtttgagc     3780

aaagaaaagg aagatctcca agagaaatgt gacatttggg aaaaaaagtt ggcacaaacc     3840

aaaagggttt tagcagcagc agaagaaaat agcaaaatgg agcaatcaaa cttagaaaag     3900

ttggaattga atgtcagaaa actgcagcag gaactagacc aactaaacag agacaagttg     3960

tcactgcata acgacatttc agcaatgcaa cagcagctcc aagaaaaacg agaagcagta     4020

aactcactgc aggaggaact agctaatgtc caagaccatt tgaacctagc aaaacaggac     4080

ctgcttcaca ccaccaagca tcaggatgtg ttgctcagtg agcagacccg actccagaag     4140

gacatcagtg aatgggcaaa taggtttgaa gactgtcaga aagaagagga gacaaaacaa     4200

caacaacttc aagtgcttca gaatgagatt gaagaaaaca agctcaaact agtccaacaa     4260

gaaatgatgt ttcagagact ccagaaagag agagaaagtg aagaaagcaa attagaaacc     4320

agtaaagtga cactgaagga gcaacagcac cagctggaaa aggaattaac agaccagaaa     4380

agcaaactgg accaagtgct ctcaaaggtg ctggcagctg aagagcgtgt taggactctg     4440

caggaagagg agaggtggtg tgagagcctg gagaagacac tctcccaaac taaacggcag     4500

ctttcagaaa gggagcagca attggtggag aaatcaggtg agctgttggc cctccagaaa     4560

gaggcagatt ctatgagggc agacttcagc cttctgcgga accagttctt gacagaaaga     4620

aagaaagctg agaagcaggt ggccagcctg aaggaagcac ttaagatcca gcggagccag     4680

ctggagaaaa accttcttga gcaaaaacag gagaacagct gcatacaaaa ggaaatggca     4740

acaattgaac tggtagccca ggacaaccat gagcgggcca ggcgcctgat gaaggagctc     4800

aaccagatgc agtatgagta cacggagctc aagaaacaga tggcaaacca aaaagatttg     4860

gagagaagac aaatggaaat cagtgatgca atgaggacac ttaaatctga ggtgaaggat     4920

gaaatcagaa ccagcttgaa gaatcttaat cagtttcttc cagaactacc agcagatcta     4980

gaagctattt tggaaagaaa cgaaaaccta gaaggagaat tggaaagctt gaaagagaac     5040

cttccattta ccatgaatga gggacctttt gaagaaaaac tgaacttttc ccaagttcac     5100

ataatggatg aacactggcg tggagaagca ctccgggaga aactgcgtca ccgggaagac     5160

cgactcaagg cccaactccg acactgtatg tccaagcaag cagaagtatt aattaaagga     5220

aagcggcaga cagagggcac tttacacagt ttgaggagac aagtagatgc tttaggggaa     5280

ttggtcacca gcacctctgc agattcagcg tcatcaccca gtctgtctca gctggagtct     5340

tccctcacag aggactctca acttggacaa aatcaggaaa agaatgcctc agccagatga     5400

ggaatactgt cttgtgtaaa tatattcaag gaaaacacct ccactacctc actgacttca     5460

taattggaat gtcacatggt ttttttaatc aagatgcagt gaactgagat tctgaaactc     5520

cactgtagtt tactttgcct gtaccattaa tgccaatgtt tttataaatc acttgtacat     5580

agtacatatg ggaatagttg catatgggaa tttaaaccaa catgtggctg agcctttttt     5640

tttttaatct tcgtaacatg tttaaaaaaa aacagtgatt ttaactgcat atttgaacct     5700

acaaactggt aaatcttatt aacaaaaaga atgtacttaa ggccctcttt atttatagtg     5760

tcgagttatt tttgaatttt gcttaaaatc tatttttcat atgaaaataa aagataacaa     5820

tcaa                                                                  5824


<210> 1874
<211> 3137
<212> DNA
<213> Homo sapiens

<400> 1874
ctaaaacaga agaccataga attaacacga gcatgtcaga agcaatatga gctggaacag       60

gaattggcct tttataaaat tgatgctaaa tttgagccac taaattatta tccatcagag      120

tatgctgaaa ttgataaagc cccagatgaa agcccttaca ttggcaaatc cagatacaag      180

agaaatatgt ttgccacaga gagttatatt attgacagtg ctcaggcagt acagatcaag      240

aagatggagc cagatgaaca acttagaaat gatcacatga acttgagagg ccacacacca      300

ctggacacgc aactggaaga caaagaaaaa aaaataagtg cagcacaaac tcgactatca      360

gaactgcatg atgaaataga aaaggcagaa caacaaattt tgagagctac tgaagaattt      420

aaacaactgg aagaagctat acaactaaaa aagattagat ttcagaagca gggaaagacc      480

ttctttacaa gcagttgagt ggtagactac aacttgtaaa taaattacgc caggaagctc      540

tggatctaga actgcagatg gaaaagcaaa agcaggaaat tgccggaaag cagaaggaga      600

ttaaggacct gcaaatagcc atagatagcc tggattccaa agacccaaaa cattcccata      660

tgaaggctca aaagagcggt aaagaacaac agcttgacat tatgaacaag cagtaccaac      720

aacttgaaag tcgtttggat gagatacttt ctagaattgc taaggaaacg gaagagatta      780

aggaccttga agaacagctt actgaaggcc agatagcagc aaatgaagcc ctgaagaagg      840

atttagaagg tgttatcagt gggttgcaag aatacctggg gaccattaaa ggccaggcaa      900

ctcaggccca gaatgagtgc aggaagctgc gggatgagaa agagacattg ttgcagagat      960

tgacagaagt cgagcaggag agagaccagc tggaaatagt tgccatggat gcagaaaata     1020

tgaggaagga gcttgcagag ctagaaagtg ccctccaaga gcagcatgag gtgaatgcat     1080

ctttgcagca gacccaggga gatctcagtg cctatgaagc tgagctagag gctcggctaa     1140

acctaaggga tgctgaagcc aaccagctca aggaagagtt ggaaaaagta acaagactta     1200

cccagttaga acaatcagcc cttcaagcag aacttgagaa ggaaaggcaa gccctcaaga     1260

atgcccttgg aaaagcccag ttctcagaag aaaaggagca agagaacagt gagctccatg     1320

caaaacttaa acacttgcag gatgacaata atctgttaaa acagcaactt aaagatttcc     1380

agaatcacct taaccatgtg gttgatggtt tggttcgtcc agaagaagtg gcagctcgtg     1440

tggatgagct aagaagaaaa ctgaaattag gaactgggga aatgaacatc catagtcctt     1500

cagatgtctt agggaaaagt cttgctgatt tacagaaaca attcagtgaa attcttgcac     1560

gctccaagtg ggaaagagat gaagcacaag ttagagagag aaaactccaa gaagaaatgg     1620

ctctgcagca agagaaactg gcaactggac aagaagagtt caggcaggcc tgtgagagag     1680

ccctggaagc aagaatgaat tttgataaga ggcaacatga agcaagaatc cagcaaatgg     1740

agaatgaaat tcactatttg caagaaaatc taaaaagtat ggaggaaatc caaggcctta     1800

cagatctcca acttcaggaa gctgatgaag agaaggagag aattctggcc caactccgag     1860

agttagagaa aaagaagaaa cttgaagatg ccaaatctca ggagcaagtt tttggtttag     1920

ataaagaact gaagaaacta aagaaagccg tggccacctc tgataagcta gccacagctg     1980

agctcaccat tgccaaagac cagctgaagt cccttcatgg aactgttatg aaaattaacc     2040

aggagcgagc agaggagttg caggaagcag agaggttcag cagaaaggca gcacaagcag     2100

ccagagatct cacccgagca gaagctgaga tcgaactcct gcagaatctc ctcaggcaga     2160

agggggagca gtttcgactt gagatggaga aaacaggtgt aggtactgga gcaaactcac     2220

aggtcctaga aattgagaaa ctgaatgaga caatggaacg acaaaggaca gagattgcaa     2280

ggctgcagaa tgtactagac ctcactggaa gtgacaacaa aggaggcttt gaaaatgttt     2340

tagaagaaat tgctgaactt cgacgtgaag tttcttatca gaatgattac ataagcagca     2400

tggcagatcc tttcaaaaga cgaggctatt ggtactttat gccaccacca ccatcatcaa     2460

aagtttccag ccatagttcc caggccacca aggactctgg tgttggcctt aagtactcag     2520

cctcaactcc tgttagaaaa ccacgccctg ggcagcagga tgggaaggaa ggcagtcaac     2580

ctccccctgc ctcaggatac tgggtttatt ctcccatcag gagtgggtta cataaactgt     2640

ttccaagtag agatgcagac agtggaggag atagtcagga agagagtgag ctggatgacc     2700

aagaagaacc cccatttgtg cctcctcctg gatacatgat gtatactgtg cttcctgatg     2760

gttctcctgt accccagggc atggccctgt atgcaccacc tcctcccttg ccaaacaata     2820

gccgacctct cacccctggc actgttgttt atggcccacc tcctgctggg gcccccatgg     2880

tgtatgggcc tccacccccc aacttctcca tccccttcat ccctatgggt gtgctgcatt     2940

gcaacgtccc tgaacaccat aacttagtaa gtggaaagac atacaactct ctttccacac     3000

tgcttccatg ggtgactgat aaggttatat acttaatgag ttgacctatt tatgactgga     3060

ttatatggca aagtgtgttt gtaaggctga tgtttagaac tgtgcaagca ttctcttatt     3120

aaaattctct tataaaa                                                    3137


<210> 1875
<211> 7660
<212> DNA
<213> Homo sapiens

<400> 1875
cgaacttctc ccgctctacc tcagcctgcg ggactgctcg gctcggcttc taggcgagac       60

aggggctccc tgtgtttccc aggctgcagt gcagtggcca gtcacaaggt tgatcatagc      120

acattgtagc ctggagctcc tgggatcaag caatcctcct gcctcatcct ctggagtaac      180

tgggactgca agtatacata ccgtgcctga cgaaatatca caatatttgg ttttgatgaa      240

cacctggctt tattcttgca atgaagaaag gttctcaaca aaaaatattc tccaaagcaa      300

agataccatc atcatctcac tctcctatcc catcatctat gtccaatatg agatctaggt      360

cactttcacc tttgattgga tcagagactc taccttttca ttctggagga cagtggtgtg      420

agcaagttga gattgcagat gaaaacaata tgcttttgga ctatcaagac cataaaggag      480

ctgattcaca tgcaggagtt agatatatta cagaggccct cattaaaaaa cttactaaac      540

aggataattt ggctttgata aaatctctga acctttcact ttctaaagac ggtggcaaga      600

aatttaagta tattgagaat ttggaaaaat gtgttaaact tgaagtactg aatctcagct      660

ataatctaat agggaagatt gaaaagttgg acaagctgtt aaaattacgt gaactcaact      720

tatcatataa caaaatcagc aaaattgaag gcatagaaaa tatgtgtaat ctgcaaaagc      780

ttaaccttgc aggaaatgaa attgagcata ttccagtatg gttagggaag aagttaaaat      840

ctttgcgagt cctcaatttg aaaggcaaca agatatcatc gctccaagat ataagcaagt      900

tgaaaccgct tcaagatttg atttctctga tcctagttga aaatccagtt gtgacccttc      960

ctcattacct ccagtttacc attttccacc tccgttcatt ggaaagtttg gaaggtcagc     1020

cagtaaccac tcaggataga caggaggctt ttgagagatt cagtttagaa gaggtagaaa     1080

gactggaaag agacctagaa aaaaagatga tagaaactga agagcttaag agcaaacaaa     1140

caaggttcct tgaggaaatt aaaaatcaag ataaattgaa taaatcatta aaagaggagg     1200

ccatgttaca gaaacagagc tgtgaggaac tcaagagtga cttaaacaca aaaaatgaat     1260

tgctaaaaca gaagaccata gaattaacac gagcatgtca gaagcaatat gagctggaac     1320

aggaattggc cttttataaa attgatgcta aatttgagcc actaaattat tatccatcag     1380

agtatgctga aattgataaa gccccagatg aaagccctta cattggcaaa tccagataca     1440

agagaaatat gtttgccaca gagagttata ttattgacag tgctcaggca gtacagatca     1500

agaagatgga gccagatgaa caacttagaa atgatcacat gaacttgaga ggccacacac     1560

cactggacac gcaactggaa gacaaagaaa aaaaaataag tgcagcacaa actcgactat     1620

cagaactgca tgatgaaata gaaaaggcag aacaacaaat tttgagagct actgaagaat     1680

ttaaacaact ggaagaagct atacaactaa aaaagatttc agaagcaggg aaagaccttc     1740

tttacaagca gttgagtggt agactacaac ttgtaaataa attacgccag gaagctctgg     1800

atctagaact gcagatggaa aagcaaaagc aggaaattgc cggaaagcag aaggagatta     1860

aggacctgca aatagccata gatagcctgg attccaaaga cccaaaacat tcccatatga     1920

aggctcaaaa gagcggtaaa gaacaacagc ttgacattat gaacaagcag taccaacaac     1980

ttgaaagtcg tttggatgag atactttcta gaattgctaa ggaaacggaa gagattaagg     2040

accttgaaga acagcttact gaaggccaga tagcagcaaa tgaagccctg aagaaggatt     2100

tagaaggtgt tatcagtggg ttgcaagaat acctggggac cattaaaggc caggcaactc     2160

aggcccagaa tgagtgcagg aagctgcggg atgagaaaga gacattgttg cagagattga     2220

cagaagtcga gcaggagaga gaccagctgg aaatagttgc catggatgca gaaaatatga     2280

ggaaggagct tgcagagcta gaaagtgccc tccaagagca gcatgaggtg aatgcatctt     2340

tgcagcagac ccagggagat ctcagtgcct atgaagctga gctagaggct cggctaaacc     2400

taagggatgc tgaagccaac cagctcaagg aagagttgga aaaagtaaca agacttaccc     2460

agttagaaca atcagccctt caagcagaac ttgagaagga aaggcaagcc ctcaagaatg     2520

cccttggaaa agcccagttc tcagaagaaa aggagcaaga gaacagtgag ctccatgcaa     2580

aacttaaaca cttgcaggat gacaataatc tgttaaaaca gcaacttaaa gatttccaga     2640

atcaccttaa ccatgtggtt gatggtttgg ttcgtccaga agaagtggca gctcgtgtgg     2700

atgagctaag aagaaaactg aaattaggaa ctggggaaat gaacatccat agtccttcag     2760

atgtcttagg gaaaagtctt gctgatttac agaaacaatt cagtgaaatt cttgcacgct     2820

ccaagtggga aagagatgaa gcacaagtta gagagagaaa actccaagaa gaaatggctc     2880

tgcagcaaga gaaactggca actggacaag aagagttcag gcaggcctgt gagagagccc     2940

tggaagcaag aatgaatttt gataagaggc aacatgaagc aagaatccag caaatggaga     3000

atgaaattca ctatttgcaa gaaaatctaa aaagtatgga ggaaatccaa ggccttacag     3060

atctccaact tcaggaagct gatgaagaga aggagagaat tctggcccaa ctccgagagt     3120

tagagaaaaa gaagaaactt gaagatgcca aatctcagga gcaagttttt ggtttagata     3180

aagaactgaa gaaactaaag aaagccgtgg ccacctctga taagctagcc acagctgagc     3240

tcaccattgc caaagaccag ctgaagtccc ttcatggaac tgttatgaaa attaaccagg     3300

agcgagcaga ggagttgcag gaagcagaga ggttcagcag aaaggcagca caagcagcca     3360

gagatctcac ccgagcagaa gctgagatcg aactcctgca gaatctcctc aggcagaagg     3420

gggagcagtt tcgacttgag atggagaaaa caggtgtagg tactggagca aactcacagg     3480

tcctagaaat tgagaaactg aatgagacaa tggaacgaca aaggacagag attgcaaggc     3540

tgcagaatgt actagacctc actggaagtg acaacaaagg aggctttgaa aatgttttag     3600

aagaaattgc tgaacttcga cgtgaagttt cttatcagaa tgattacata agcagcatgg     3660

cagatccttt caaaagacga ggctattggt actttatgcc accaccacca tcatcaaaag     3720

tttccagcca tagttcccag gccaccaagg actctggtgt tggccttaag tactcagcct     3780

caactcctgt tagaaaacca cgccctgggc agcaggatgg gaaggaaggc agtcaacctc     3840

cccctgcctc aggatactgg gtttattctc ccatcaggag tgggttacat aaactgtttc     3900

caagtagaga tgcagacagt ggaggagata gtcaggaaga gagtgagctg gatgaccaag     3960

aagaaccccc atttgtgcct cctcctggat acatgatgta tactgtgctt cctgatggtt     4020

ctcctgtacc ccagggcatg gccctgtatg caccacctcc tcccttgcca aacaatagcc     4080

gacctctcac ccctggcact gttgtttatg gcccacctcc tgctggggcc cccatggtgt     4140

atgggcctcc accccccaac ttctccatcc ccttcatccc tatgggtgtg ctgcattgca     4200

acgtccctga acaccataac ttagagaatg aagtttctag attagaagac ataatgcagc     4260

atttaaaatc aaagaagcgg gaagaaaggt ggatgagagc atccaagcgg cagtcggaga     4320

aagaaatgga agaactgcat cataatattg atgatctttt gcaagagaag aaaagcttag     4380

agtgtgaagt agaagaatta catagaactg tccagaaacg tcaacagcaa aaggacttca     4440

ttgatggaaa tgttgagagt cttatgactg aactagaaat agaaaaatca ctcaaacatc     4500

atgaagatat tgtagatgaa attgagtgca ttgagaagac tcttctgaaa cgtcgctcag     4560

agctcaggga agctgaccga ctcctggcag aggctgagag tgaactttca tgcactaaag     4620

aaaagacaaa aaatgctgtt gaaaagttca ctgatgccaa gagaagttta ttgcaaactg     4680

agtcagatgc tgaggaatta gaaaggagag ctcaggaaac tgctgttaac ctcgtcaaag     4740

ctgatcagca gctaagatcg ctccaggctg atgcaaagga tttggagcag cacaaaatca     4800

agcaagaaga aatcttgaaa gaaataaaca aaattgtagc agcaaaagac tcagacttcc     4860

aatgtttaag caagaagaag gaaaaactga cagaagagct tcagaaacta cagaaagaca     4920

tagagatggc agaacgcaat gaggatcacc acctgcaggt ccttaaagaa tctgaggtgc     4980

ttcttcaggc caaaagagcc gagctggaaa agctgaaaag ccaggtgaca agtcagcagc     5040

aggagatggc tgtcttggac aggcagttag ggcataaaaa ggaggagctg catctactcc     5100

aaggaagcat ggtccaggca aaagctgacc tccaggaagc tctgagactg ggagagactg     5160

aagtaactga gaagtgcaat cacattaggg aagtaaaatc tcttctggaa gaactgagtt     5220

ttcagaaagg agaactaaat gttcagatta gtgaaagaaa aactcaactt acacttataa     5280

agcaggaaat tgaaaaagag gaagaaaatc ttcaggttgt tttaaggcag atgtctaaac     5340

ataaaaccga actaaagaat attctggaca tgttgcaact tgaaaaccat gagctacaag     5400

gtttgaagct acaacatgac caaagggtat ctgaattaga gaagactcag gtggcagtgc     5460

tagaggagaa actggagtta gagaatttgc agcagatatc ccagcagcag aaaggggaaa     5520

tagagtggca gaagcagctc cttgagaggg ataaacgaga aatagaacga atgactgctg     5580

agtcccgagc tttacaatcg tgtgttgagt gtttgagcaa agaaaaggaa gatctccaag     5640

agaaatgtga catttgggaa aaaaagttgg cacaaaccaa aagggtttta gcagcagcag     5700

aagaaaatag caaaatggag caatcaaact tagaaaagtt ggaattgaat gtcagaaaac     5760

tgcagcagga actagaccaa ctaaacagag acaagttgtc actgcataac gacatttcag     5820

caatgcaaca gcagctccaa gaaaaacgag aagcagtaaa ctcactgcag gaggaactag     5880

ctaatgtcca agaccatttg aacctagcaa aacaggacct gcttcacacc accaagcatc     5940

aggatgtgtt gctcagtgag cagacccgac tccagaagga catcagtgaa tgggcaaata     6000

ggtttgaaga ctgtcagaaa gaagaggaga caaaacaaca acaacttcaa gtgcttcaga     6060

atgagattga agaaaacaag ctcaaactag tccaacaaga aatgatgttt cagagactcc     6120

agaaagagag agaaagtgaa gaaagcaaat tagaaaccag taaagtgaca ctgaaggagc     6180

aacagcacca gctggaaaag gaattaacag accagaaaag caaactggac caagtgctct     6240

caaaggtgct ggcagctgaa gagcgtgtta ggactctgca ggaagaggag aggtggtgtg     6300

agagcctgga gaagacactc tcccaaacta aacggcagct ttcagaaagg gagcagcaat     6360

tggtggagaa atcaggtgag ctgttggccc tccagaaaga ggcagattct atgagggcag     6420

acttcagcct tctgcggaac cagttcttga cagaaagaaa gaaagctgag aagcaggtgg     6480

ccagcctgaa ggaagcactt aagatccagc ggagccagct ggagaaaaac cttcttgagc     6540

aaaaacagga gaacagctgc atacaaaagg aaatggcaac aattgaactg gtagcccagg     6600

acaaccatga gcgggccagg cgcctgatga aggagctcaa ccagatgcag tatgagtaca     6660

cggagctcaa gaaacagatg gcaaaccaaa aagatttgga gagaagacaa atggaaatca     6720

gtgatgcaat gaggacactt aaatctgagg tgaaggatga aatcagaacc agcttgaaga     6780

atcttaatca gtttcttcca gaactaccag cagatctaga agctattttg gaaagaaacg     6840

aaaacctaga aggagaattg gaaagcttga aagagaacct tccatttacc atgaatgagg     6900

gaccttttga agaaaaactg aacttttccc aagttcacat aatggatgaa cactggcgtg     6960

gagaagcact ccgggagaaa ctgcgtcacc gggaagaccg actcaaggcc caactccgac     7020

actgtatgtc caagcaagca gaagtattaa ttaaaggaaa gcggcagaca gagggcactt     7080

tacacagttt gaggagacaa gtagatgctt taggggaatt ggtcaccagc acctctgcag     7140

attcagcgtc atcacccagt ctgtctcagc tggagtcttc cctcacagag gactctcaac     7200

ttggacaaaa tcaggaaaag aatgcctcag ccagatgagg aatactgtct tgtgtaaata     7260

tattcaagga aaacacctcc actacctcac tgacttcata attggaatgt cacatggttt     7320

ttttaatcaa gatgcagtga actgagattc tgaaactcca ctgtagttta ctttgcctgt     7380

accattaatg ccaatgtttt tataaatcac ttgtacatag tacatatggg aatagttgca     7440

tatgggaatt taaaccaaca tgtggctgag cctttttttt tttaatcttc gtaacatgtt     7500

taaaaaaaaa cagtgatttt aactgcatat ttgaacctac aaactggtaa atcttattaa     7560

caaaaagaat gtacttaagg ccctctttat ttatagtgtc gagttatttt tgaattttgc     7620

ttaaaatcta tttttcatat gaaaataaaa gataacaatc                           7660


<210> 1876
<211> 1894
<212> DNA
<213> Homo sapiens

<400> 1876
gggaaacgcc tccgcgtccc ttccaacagt accggagagg gagaggggcg tggctgagac       60

tagccccgac cacgcgcgcg cggcccctcg gcaaccggca caacacaaca aaatggctgc      120

cgcgccgctg ggcccctgag gaaagagccc gaacttctcc cgctctacct cagcctgcgg      180

gactgctcgg ctcggcttct aggcggtttt gatgaacacc tggctttatt cttgcaatga      240

agaaaggttc tcaacaaaaa atattctcca aagcaaagat accatcatca tctcactctc      300

ctatcccatc atctatgtcc aatatgagat ctaggtcact ttcacctttg attggatcag      360

agactctacc ttttcattct ggaggacagt ggtgtgagca agttgagatt gcagatgaaa      420

acaatatgct tttggactat caagaccata aaggagctga ttcacatgca ggagttagat      480

atattacaga ggccctcatt aaaaaactta ctaaacagga taatttggct ttgataaaat      540

ctctgaacct ttcactttct aaagacggtg gcaagaaatt taagtatatt gagaatttgg      600

aaaaatgtgt taaacttgaa gtactgaatc tcagctataa tctaataggg aagattgaaa      660

agttggacaa gctgttaaaa ttacgtgaac tcaacttatc atataacaaa atcagcaaaa      720

ttgaaggcat agaaaatatg tgtaatctgc aaaagcttaa ccttgcagga aatgaaattg      780

agcatattcc agtatggtta gggaagaagt taaaatcttt gcgagtcctc aatttgaaag      840

gcaacaagat atcatcgctc caagatataa gcaagttgaa accgcttcaa gatttgattt      900

ctctgatcct agttgaaaat ccagttgtga cccttcctca ttacctccag tttaccattt      960

tccacctccg ttcattggaa agtttggaag gtcagccagt aaccactcag gatagacagg     1020

aggcttttga gagattcagt ttagaagagg tagaaagact ggaaagagac ctagaaaaaa     1080

agatgataga aactgaagag cttaagagca aacaaacaag gttccttgag gaaattaaaa     1140

atcaagataa attgaataaa tcattaaaag aggaggccat gttacagaaa cagagctgtg     1200

aggaactcaa gagtgactta aacacaaaaa atgaattgct aaaacagaag accatagaat     1260

taacacgagc atgtcagaag caatatgagc tggaacagga attggccttt tataaaattg     1320

atgctaaatt tgagccacta aattattatc catcagagta tgctgaaatt gataaagccc     1380

cagatgaaag cccttacatt ggcaaatcca gatacaagag aaatatgttt gccacagaga     1440

gttatattat tgacagtgct caggcagtac agatcaagaa gatggagcca gatgaacaac     1500

ttagaaatga tcacatgaac ttgagaggcc acacaccact ggacacgcaa ctggaagacc     1560

acaaactcga ctatcagaac tgcatgatga aatagaaaag gcagaacaac aaattttgag     1620

agctactgaa gaatttaaac aactggaaga agctatacaa ctaaaaaaga tttcagaagc     1680

agggaaagac cttctttaca agcagttgag tggtagacta caacttgtaa ataaattacg     1740

ccaggaagct ctggatctag aactgcagat ggaaaagcaa aagcaggaaa ttgccggaaa     1800

gcagaaggag attaaggacc tgcaaatagc catagatagc ctggattcca aagacccaaa     1860

acatgtgagt aaattaagaa attttgactt gttc                                 1894


<210> 1877
<211> 3569
<212> DNA
<213> Homo sapiens

<400> 1877
gacgaggcgt ttccgatctt tgccgcagtc cggatttcct gggtctctgg gcactgaagg       60

ggaaatgccc tcgggatgtt tctagcaacc cccttccccc aacacacaca cactagttgg      120

cattctcttc cagaaactta tcattttctt ttttaaacct cccatcctca gactccccaa      180

attaacaagt ctttttagcc tcttggattg ggattaggat gacagttttt cagtgagggc      240

gcagaaaaac agtgcatttc agcaccaagg acagacacaa tcttcatggt tcctgggctc      300

tgagtcagac tgtcgaaaat attggcctaa tatatgtgct gtgattcaga ctttgtggcg      360

aggaacaaat cacaagacag tggcatagca gagatggaag aacttcctgt accacataac      420

atcaaaataa gcaatataac gtgtgactca ttcaagattt catgggaaat ggattcaaaa      480

tcaaaggatc gcattacaca ctattttatt gacctcaaca agaaagagaa caagaactcc      540

aataaattta aacacaagga tgttcccaca aaattggtgg caaaagctgt tcccttgcct      600

atgactgtcc gtggacactg gtttttaagc ccaagaactg aatatacagt agcagtgcag      660

actgcctcaa aacaagttga tggtgattat gttgtgtctg aatggagtga aattatagaa      720

ttctgcaccg cagactattc aaaagttcat ctaacacaat tgttggagaa ggctgaagtg      780

attgcaggac gcatgcttaa gttttctgtt ttttatcgta atcagcacaa agaatatttt      840

gactatgttc gagaacatca tgggaatgct atgcagccat ctgtcaagga taacagtggt      900

agccatggct ctcctatcag tggaaaatta gaaggcatct tcttcagctg cagcactgaa      960

ttcaatactg gaaagccacc ccaggattca ccttatggaa gatacaggtt tgagattgcc     1020

gcagaaaaac tttttaaccc caatactaac ttatactttg gggacttcta ctgtatgtac     1080

actgcttatc attatgtgat tcttgttatt gctcctgtgg gatcaccagg agatgaattt     1140

tgtaagcagc gccttcctca actaaattct aaggataata aatttttgac ctgtacagaa     1200

gaagatgggg tgctggttta ccaccatgcc caggatgtca ttttagaagt catttacact     1260

gaccctgtgg atctttctgt gggcaccgtg gcagaaatca ctggtcatca gctcatgagt     1320

ttgtctactg caaatgcaaa gaaagatccc agctgcaaaa cctgtaatat cagtgttgga     1380

cgttaatgcc cacttttctt attcttactc agcccctttt cctcccttag gagcattggt     1440

cctctgttgt ccatttttat caccagatgt tttccactga agcatgcaca tgccactgtc     1500

accaaaacaa acaactacca ctttccaaat ttcattcaga accattttag tgttttccta     1560

ttccctaccc ctcccactac tttcaatgat gaaataccct aagttaagtt ctccttttga     1620

cactttattg cctagatgct gcaatgtttt tatgtttcct ttatgccaaa cataacaaaa     1680

cagttatata gactgcttta gcaaagtaca caataatggc ttataaatgg tgtttaaata     1740

tgcattcatt ttaatctact gaacaaatat tgggataact ccaaaccgca tgaaagggtg     1800

taattgcagc atgagttaaa tcttgaagcc tagaattgtc agcacttcca acttcttgtt     1860

tgacagtgtt atttatgtta tttatattag ctaacaggaa acaactactg tgtttcaaca     1920

taataaatat aatagaaaaa tattttattt gtattgttgt ataaaatatt tacaatcata     1980

tagaatatat agagttacat tttaatagca actgtgtaca tgtcacgaaa ccatttccct     2040

tatcaaagat gtaatttgta aacctcaaat agttgtgtat ctgtcctgtt agaagtagat     2100

gacttcaatt aaacaaattt atgaaggaca ttattctgat tcataaaagt tataaaatat     2160

taggtaaata cagagaaaac aataagcctc tgaaataagt ctgtttctga aatagtcaat     2220

agtcttccca tccaaactat aagagaatgt gaatttcttc aacatcatac ttaaacatta     2280

cagaaaatag aaatacaaac aaggttggta catgagagaa aatgttgacc ttttacttcc     2340

ttttacaaaa atgaaaataa taaacatgtt ttcgtataaa ataacacaaa atgatataca     2400

ctgaagttga tgaagcaaat aaatattctg gcttcttttt caaggtatca gggcaaacaa     2460

tttccaaact tttcattttg tacagaagga tgaataacta cagctcatgg gaaatgtttt     2520

gactttacaa agtatagatg ttggaacatt aagaaaaatg tatattccca atgaaaaaat     2580

agttatatca tcttatagta aaccaaaaga ttagcaataa tactatggac acattagatt     2640

atatactaca gacacatatc tatccaaaat acctatttta aatttttaat acaatatttt     2700

attttaatat aaacatctgt cagttataga caaagataat aattcacaaa gtacatgcta     2760

tcagaatgaa ctttggtaac cagaaatgta aaatttcaaa taacggataa aataatgtgt     2820

tatttttata gagaaagaaa aaaatagcaa cacaatctag tttattttag ggtactgaga     2880

gcctagcaga cttaaaggac aaggtagtaa atgttttatc actcaaaaat ccattagaag     2940

tttcaaataa attgctttct tgctagctgt attccttcct acttgaaaag cgaatttctt     3000

ttcctcctat gattgatttt ttaaaatcat gctcttttcc atacatcaac ataaacagtc     3060

tttggatact aaataaactt tccctaacaa gtgtcctagc tatgttattt agatttgata     3120

aaatattaga catttttaaa aatacttgta ttgactatga gttttctgct tggcatggag     3180

gacactgaat tttttcccaa ttatatggct acctgttgta ttcttccccc cgtttaaatc     3240

ccttctcctt gtatataatt aaacttgcta ttccttctta aaaacagcta atactaccac     3300

taaagtgctt ccattttcat tgtgtcaaaa ctacttagca aggatggcag aggaaaataa     3360

actttacttt atatcatggg tgaaagtgat cataacattt cctgaacctc aaatagtttt     3420

ggccacatct tgcttgctga tgaggacctc taatagtctc agtttggctt ttatgtgctt     3480

atattcataa tactcatctg ccattggtat cctatcttcc ttttgtggac ttctgcaaaa     3540

caaaaataca tttgttagtt cacaatgaa                                       3569


<210> 1878
<211> 3578
<212> DNA
<213> Homo sapiens

<400> 1878
cccgccggga gcgcgcgcct cccatcctcg cgccgggtcc tgctcggtct ctcagagccg       60

cacactccgc ggagctcctg ccacagccgt cgccttcgcg gcggctctcc agccccgcgc      120

ctcagcctcg gcgccgcatc accgcgtccc aggcctcctt ccctccctct gccactcccc      180

ctccctttcc cgctcttctt gcccacccgg ccggcagaga gagcctggat acgaagcagg      240

cgggcttcag agtgggttgg aaaaatggag gtgccgcgcc tggatcatgc cctcaacagc      300

cccaccagcc cctgtgagga ggtgatcaaa aacctcagcc tggaggccat tcagctgtgc      360

gaccgggacg ggaacaaatc acaagacagt ggcatagcag agatggaaga acttcctgta      420

ccacataaca tcaaaataag caatataacg tgtgactcat tcaagatttc atgggaaatg      480

gattcaaaat caaaggatcg cattacacac tattttattg acctcaacaa gaaagagaac      540

aagaactcca ataaatttaa acacaaggat gttcccacaa aattggtggc aaaagctgtt      600

cccttgccta tgactgtccg tggacactgg tttttaagcc caagaactga atatacagta      660

gcagtgcaga ctgcctcaaa acaagttgat ggtgattatg ttgtgtctga atggagtgaa      720

attatagaat tctgcaccgc agactattca aaagttcatc taacacaatt gttggagaag      780

gctgaagtga ttgcaggacg catgcttaag ttttctgttt tttatcgtaa tcagcacaaa      840

gaatattttg actatgttcg agaacatcat gggaatgcta tgcagccatc tgtcaaggat      900

aacagtggta gccatggctc tcctatcagt ggaaaattag aaggcatctt cttcagctgc      960

agcactgaat tcaatactgg aaagccaccc caggattcac cttatggaag atacaggttt     1020

gagattgccg cagaaaaact ttttaacccc aatactaact tatactttgg ggacttctac     1080

tgtatgtaca ctgcttatca ttatgtgatt cttgttattg ctcctgtggg atcaccagga     1140

gatgaatttt gtaagcagcg ccttcctcaa ctaaattcta aggataataa atttttgacc     1200

tgtacagaag aagatggggt gctggtttac caccatgccc aggatgtcat tttagaagtc     1260

atttacactg accctgtgga tctttctgtg ggcaccgtgg cagaaatcac tggtcatcag     1320

ctcatgagtt tgtctactgc aaatgcaaag aaagatccca gctgcaaaac ctgtaatatc     1380

agtgttggac gttaatgccc acttttctta ttcttactca gccccttttc ctcccttagg     1440

agcattggtc ctctgttgtc catttttatc accagatgtt ttccactgaa gcatgcacat     1500

gccactgtca ccaaaacaaa caactaccac tttccaaatt tcattcagaa ccattttagt     1560

gttttcctat tccctacccc tcccactact ttcaatgatg aaatacccta agttaagttc     1620

tccttttgac actttattgc ctagatgctg caatgttttt atgtttcctt tatgccaaac     1680

ataacaaaac agttatatag actgctttag caaagtacac aataatggct tataaatggt     1740

gtttaaatat gcattcattt taatctactg aacaaatatt gggataactc caaaccgcat     1800

gaaagggtgt aattgcagca tgagttaaat cttgaagcct agaattgtca gcacttccaa     1860

cttcttgttt gacagtgtta tttatgttat ttatattagc taacaggaaa caactactgt     1920

gtttcaacat aataaatata atagaaaaat attttatttg tattgttgta taaaatattt     1980

acaatcatat agaatatata gagttacatt ttaatagcaa ctgtgtacat gtcacgaaac     2040

catttccctt atcaaagatg taatttgtaa acctcaaata gttgtgtatc tgtcctgtta     2100

gaagtagatg acttcaatta aacaaattta tgaaggacat tattctgatt cataaaagtt     2160

ataaaatatt aggtaaatac agagaaaaca ataagcctct gaaataagtc tgtttctgaa     2220

atagtcaata gtcttcccat ccaaactata agagaatgtg aatttcttca acatcatact     2280

taaacattac agaaaataga aatacaaaca aggttggtac atgagagaaa atgttgacct     2340

tttacttcct tttacaaaaa tgaaaataat aaacatgttt tcgtataaaa taacacaaaa     2400

tgatatacac tgaagttgat gaagcaaata aatattctgg cttctttttc aaggtatcag     2460

ggcaaacaat ttccaaactt ttcattttgt acagaaggat gaataactac agctcatggg     2520

aaatgttttg actttacaaa gtatagatgt tggaacatta agaaaaatgt atattcccaa     2580

tgaaaaaata gttatatcat cttatagtaa accaaaagat tagcaataat actatggaca     2640

cattagatta tatactacag acacatatct atccaaaata cctattttaa atttttaata     2700

caatatttta ttttaatata aacatctgtc agttatagac aaagataata attcacaaag     2760

tacatgctat cagaatgaac tttggtaacc agaaatgtaa aatttcaaat aacggataaa     2820

ataatgtgtt atttttatag agaaagaaaa aaatagcaac acaatctagt ttattttagg     2880

gtactgagag cctagcagac ttaaaggaca aggtagtaaa tgttttatca ctcaaaaatc     2940

cattagaagt ttcaaataaa ttgctttctt gctagctgta ttccttccta cttgaaaagc     3000

gaatttcttt tcctcctatg attgattttt taaaatcatg ctcttttcca tacatcaaca     3060

taaacagtct ttggatacta aataaacttt ccctaacaag tgtcctagct atgttattta     3120

gatttgataa aatattagac atttttaaaa atacttgtat tgactatgag ttttctgctt     3180

ggcatggagg acactgaatt ttttcccaat tatatggcta cctgttgtat tcttcccccc     3240

gtttaaatcc cttctccttg tatataatta aacttgctat tccttcttaa aaacagctaa     3300

tactaccact aaagtgcttc cattttcatt gtgtcaaaac tacttagcaa ggatggcaga     3360

ggaaaataaa ctttacttta tatcatgggt gaaagtgatc ataacatttc ctgaacctca     3420

aatagttttg gccacatctt gcttgctgat gaggacctct aatagtctca gtttggcttt     3480

tatgtgctta tattcataat actcatctgc cattggtatc ctatcttcct tttgtggact     3540

tctgcaaaac aaaaatacat ttgttagttc acaatgaa                             3578


<210> 1879
<211> 1501
<212> DNA
<213> Homo sapiens

<400> 1879
cgggcggcag agctggagtg aagggagcta gtggtagcag tcaccattat gctcaaagcg       60

gtgatcctga ttggaggccc tcaaaaggga actcgcttca gacctttgtc ttttgaggtg      120

cccaaaccat tgtttcctgt ggcaggggtc cctatgatcc aacaccatat tgaagcctgt      180

gcccaggtcc ctggaatgca ggagattctg ctcattggct tctaccaacc tgatgagccc      240

ctcacccagt tcctagaagc cgcccagcag gagtttaacc ttccagtcag gtacctgcag      300

gaatttgccc ccctaggcac agggggtggt ctttaccatt ttcgagacca gatcctggct      360

gggagccccg aggcattctt cgtgctcaat gctgatgtct gctccgactt ccccttgagt      420

gctatgttgg aagcccaccg acgccagcgt caccctttct tactccttgg cactacggct      480

aacaggacgc aatccctcaa ctacggctgc atcgttgaga atccacagac acacgaggta      540

ttgcactatg tggagaaacc cagcacattt atcagtgaca tcatcaactg cggcatctac      600

ctcttttctc ctgaagcctt gaagcctctt cgggatgtct tccagcgtaa tcagcaggat      660

gggcaattgg aggactcacc aggcttgtgg ccaggggcag gtaccatccg cctagagcag      720

gatgtgtttt cagccctggc agggcagggc cagatatacg tgcatctcac tgatggtatc      780

tggagtcaga tcaagtccgc aggttcagcc ctctacgcct cccgcctcta cctgagccga      840

taccaggaca ctcacccaga acggctggcc aagcacaccc cagggggccc atggatccga      900

gggaatgtgt acatccaccc gaccgccaag gtggccccct cggctgtgct gggccccaac      960

gtctccatcg ggaagggggt gaccgtgggt gagggtgtgc ggctccggga gagcatcgtc     1020

ctccatggag ccactttgca ggagcacacg tgtgttctgc atagcatcgt gggctggggg     1080

agcaccgtgg gacgctgggc ccgcgtggag ggtaccccca gtgaccctaa ccccaacgat     1140

ccccgagccc gcatggacag tgagagcctc ttcaaggacg ggaagctgct gcctgctatc     1200

accatcctgg gctgccgagt ccggatccct gccgaggtgc tcatcctgaa ctcgattgtt     1260

ctgccacaca aggagctgag ccgaagcttc accaaccaga tcatcctctg agtagggctg     1320

ccagaaggcc cccagctcct acccactccc cttgaggctg ctgcctgctt ggccagcctc     1380

tgtccagaaa ggaccagaga aagccaggct ggatcgtcac atgccgggga gcaatgtgga     1440

tggcctgggg actcctgggt tttctccctc ccgactccct aataaacccc gtgaaccttg     1500

g                                                                     1501


<210> 1880
<211> 1242
<212> DNA
<213> Homo sapiens

<400> 1880
gatccactga gctggctctc gggtccctgg ggacaggtac ctgcaggaat ttgcccccct       60

aggcacaggg ggtggtacca ttttcgagac cagatcctgg ctgggagccc cgaggcattc      120

ttcgtgctca atgctgatgt ctgctccgac ttccccttga gtgctatgtt ggaagcccac      180

cgacgccagc gtcacccttt cttactcctt ggcactacgg ctaacaggac gcaatccctc      240

aactacggct gcatcgttga gaatccacag acacacgagg tattgcacta tgtggagaaa      300

cccagcacat ttatcagtga catcatcaac tgcggcatct acctcttttc tcctgaagcc      360

ttgaagcctc ttcgggatgt cttccagcgt aatcagcagg atgggcaatt ggaggactca      420

ccaggcttgt ggccaggggc aggtaccatc cgcctagagc aggatgtgtt ttcagccctg      480

gcagggcagg gccagatata cgtgcatctc actgatggta tctggagtca gatcaagtcc      540

gcaggttcag ccctctacgc ctcccgcctc tacctgagcc gataccagga cactcaccca      600

gaacggctgg ccaagcacac cccagggggc ccatggatcc gagggaatgt gtacatccac      660

ccgaccgcca aggtggcccc ctcggctgtg ctgggcccca acgtctccat cgggaagggg      720

gtgaccgtgg gtgagggtgt gcggctccgg gagagcatcg tcctccatgg agccactttg      780

caggagcaca cgtgtgttct gcatagcatc gtgggctggg ggagcaccgt gggacgctgg      840

gcccgcgtgg agggtacccc cagtgaccct aaccccaacg atccccgagc ccgcatggac      900

agtgagagcc tcttcaagga cgggaagctg ctgcctgcta tcaccatcct gggctgccga      960

gtccggatcc ctgccgaggt gctcatcctg aactcgattg ttctgccaca caaggagctg     1020

agccgaagct tcaccaacca gatcatcctc tgagtagggc tgccagaagg cccccagctc     1080

ctacccactc cccttgaggc tgctgcctgc ttggccagcc tctgtccaga aaggaccaga     1140

gaaagccagg ctggatcgtc acatgccggg gagcaatgtg gatggcctgg ggactcctgg     1200

gttttctccc tcccgactcc ctaataaacc ccgtgaacct tg                        1242


<210> 1881
<211> 1940
<212> DNA
<213> Homo sapiens

<400> 1881
agcaccggaa gccgctcccc tgtgaggctg cggaccggga gcagcggccg caggtccggg       60

cgccatggct gcggagcgga cccggccgct gcaaggctct ggcggtccga gcgtgcctag      120

tagctgtgaa cccggcgcga ggtcccgggc cccggggcgc tcgctcaggt aaatttttcc      180

ataaccttat ggagagaaag gactttgaga catggcttga taacatttct gttacatttc      240

tttctctgac ggacttgcag aaaaatgaaa ctctggatca cctgattagt ctgagtgggg      300

cagtccagct caggcatctc tccaataacc tagagactct cctcaagcgg gacttcctca      360

aactccttcc cctggagctc agtttttatt tgttaaaatg gctcgatcct cagactttac      420

tcacatgctg cctcgtctct aaacagtgga ataaggtgat aagtgcctgt acagaggtgt      480

ggcagactgc atgtaaaaat ttgggctggc agatagatga ttctgttcag gacgctttgc      540

actggaagaa ggtttatttg aaggctattt tgagaatgaa gcaactggag gaccatgaag      600

cctttgaaac ctcgtcatta attggacaca gtgccagagt gtatgcactt tactacaaag      660

atggacttct ctgtacaggg tcagatgact tgtctgcaaa gctgtgggat gtgagcacag      720

ggcagtgcgt ttatggcatc cagacccaca cttgtgcagc ggtgaagttt gatgaacaga      780

agcttgtgac aggctccttt gacaacactg tggcttgctg ggaatggagt tccggagcca      840

ggacccagca ctttcggggg cacacggggg cggtatttag cgtggactac aatgatgaac      900

tggatatctt ggtgagcggc tctgcagact tcactgtgaa agtatgggct ttatctgctg      960

ggacatgcct gaacacactc accgggcaca cggaatgggt caccaaggta gttttgcaga     1020

agtgcaaagt caagtctctc ttgcacagtc ctggagacta catcctctta agtgcagaca     1080

aatatgagat taagatttgg ccaattggga gagaaatcaa ctgtaagtgc ttaaagacat     1140

tgtctgtctc tgaggataga agtatctgcc tgcagccaag acttcatttt gatggcaaat     1200

acattgtctg tagttcagca cttggtctct accagtggga ctttgccagt tatgatattc     1260

tcagggtcat caagactcct gagatagcaa acttggcctt gcttggcttt ggagatatct     1320

ttgccctgct gtttgacaac cgctacctgt acatcatgga cttgcggaca gagagcctga     1380

ttagtcgctg gcctctgcca gagtacagga aatcaaagag aggctcaagc ttcctggcag     1440

gcgaagcatc ctggctgaat ggactggatg ggcacaatga cacgggcttg gtctttgcca     1500

ccagcatgcc tgaccacagt attcacctgg tgttgtggaa ggagcacggc tgacaccatg     1560

agccaccacc gctgactgac tttgggtgcc ggggctgcgg gttttgggtg caacctctgc     1620

ggcagccgac tgcatgaacc aaagttctca cctaatggta tcatcacgca gtgcacaatc     1680

atttatctat gttttgccag gggccagggc tcggggtggg ggagggcttg ttttattgac     1740

atacaacgca gcatgctaat ggggtacacc attgacttca tttgtactta gttatgttgg     1800

tcagtgttag aggatgcatt ttgggttcat ctttcttgag tggagtattg gttttaagta     1860

aagaaagtta aatgatccat taatctgcta attggttgcc tatgaaatca cattgtctgt     1920

tattaaagct ttttaccata                                                 1940


<210> 1882
<211> 663
<212> DNA
<213> Homo sapiens

<400> 1882
ggaaagatgg aggcagcgga gacagaggcg gaagctgcag ccctagaggt cctggctgag       60

gtggcaggca tcttggaacc tgtaggcctg caggaggagg cagaactgcc agccaagatc      120

ctggttgagt ttgtggtgga ctctcagaag aaagacaagc tgctctgcag ccagcttcag      180

gtagcggatt tcctgcagaa catcctggct caggagagac cctggtgtgt ccttcaaggc      240

tgttggtcta caacctgctg gagatgtaaa tttgccatga cttcctggag gacagcagca      300

tggagaaaga tcctagaaaa ggcctctgac ttccctcacc tcccaaccat cattacagga      360

aagactgtga actcctgagt tcagcttgat ttctgactac atcccagcaa gctctggcat      420

ctgtggatta aaatccctgg atctctctca gttgtgtatt tgttcatctt catatgctgg      480

caggaacaac tattaataca gatactcaga agccaataac atgacaggag ctgggactgg      540

tttgaacaca gggtgtgcag atggggaggg ggtactggcc ttgggcctcc tatgatgcag      600

acatggtgaa tttaattcaa ggaggaggag aatgttttag gcaggtggtt atatgtggga      660

aga                                                                    663


<210> 1883
<211> 1872
<212> DNA
<213> Homo sapiens

<400> 1883
gggattgtgg gaaggcagct gaactcggcg cctggaaaga tggaggcagc ggagacagag       60

gcggaagctg cagccctaga ggtcctggct gaggtggcag gcatcttgga acctgtaggc      120

ctgcaggagg aggcagaact gccagccaag atcctggttg agtttgtggt ggactctcag      180

aagaaagaca agctgctctg cagccagctt caggtagcgg atttcctgca gaacatcctg      240

gctcaggagg acactgctaa gggtctcgac cccttggctt ctgaagacac gagccgacag      300

aaggcaattg cagctaagga acaatggaaa gagctgaagg ccacctacag ggagcacgta      360

gaggccatca aaattggcct caccaaggcc ctgactcaga tggaggaagc ccagaggaaa      420

cggacacaac tccgggaagc ctttgagcag ctccaggcca agaaacaaat ggccatggag      480

aaacgcagag cagtccagaa ccagtggcag ctacaacagg agaagcatct gcagcatctg      540

gcggaggttt ctgcagaggt gagggagcgt aagacaggga ctcagcagga gcttgacagg      600

gtgtttcaga aacttggaaa cctgaagcag caggcagaac aggagcggga caagctgcag      660

aggtatcaga ccttcctcca gcttctgtat accctgcagg gtaagctgtt gttccctgag      720

gctgaggctg aggcagagaa tcttccagat gataaacccc agcagccgac tcgaccccag      780

gagcagagta caggagacac catggggaga gaccctggtg tgtccttcaa ggctgttggt      840

ctacaacctg ctggagatgt aaatttgcca tgacttcctg gaggacagca gcatggagaa      900

agatcctaga aaaggcctct gacttccctc acctcccaac catcattaca ggaaagactg      960

tgaactcctg agttcagctt gatttctgac tacatcccag caagctctgg catctgtgga     1020

ttaaaatccc tggatctctc tcagttgtgt atttgttcat cttcatatgc tggcaggaac     1080

aactattaat acagatactc agaagccaat aacatgacag gagctgggac tggtttgaac     1140

acagggtgtg cagatgggga gggggtactg gccttgggcc tcctatgatg cagacatggt     1200

gaatttaatt caaggaggag gagaatgttt taggcaggtg gttatatgtg ggaagataat     1260

tttattcatg gatccaaatg tttgttgagt cctttctttg tgctaaggtt cttgcggtga     1320

accagaatta taacagtgag ctcatctgac tgttttagga tgtacagcct agtgttaaca     1380

ttcttggtat ctttttgtgc cttatctaaa acatttctcg atcactggtt tcagatgttc     1440

atttattata ttcttttcaa agattcagag attggctttt gtcatccact attgtatgtt     1500

ttgtttcatt gacctctagt gataccttga tctttcccac tttctgtttt cggattggag     1560

aagatgtacc ttttttgtca actcttactt ttatcagatg atcaactcac gtatttggat     1620

ctttatttgt tttctcaaat aaatatttaa ggttatacat ttcttctgac ttcctttatt     1680

ttcacaatca ttcaattcat agcatttcct atattctgtt ataattattt cattgattca     1740

taaatttctt tgaaaaataa tttggtcttc tattgattgt gagaagataa tctaagttta     1800

atttggtcag agaatatcat ctgtttaata aactttgaaa tttggtgagt gaattatctt     1860

ttttactgat aa                                                         1872


<210> 1884
<211> 3603
<212> DNA
<213> Homo sapiens

<400> 1884
agggaggggg tggtgtcccc agccggtttg gggggtgcgt tgcccggaga cggaaagttt       60

gggagcccga gcaggctcgg ctgcagcctc ggggaggggg tccagcgggt ggcggccctg      120

gggatgggga aggagcagga gctgctggag gcggcccgca ccgggcacct cccggcggtg      180

gagaagctgc tgtccgggaa gcggctctcc tcaggctttg ggggcggcgg cggcggtggc      240

tctgggggcg gcggcggcgg cagcggcggc ggcggcggcg gcctcggctc ttccagccac      300

cccctctcca gtctgctcag aaatcaagct ccatgagggc agactttgtc tttttccatc      360

tgcatctcca gcccctagaa ggcgcacttc acgtgtctgc tgagtacatg ccatgtggag      420

agggccaaat gtgaactgtg ttgacagcac tggctacaca cccctgcacc atgctgcttt      480

gaatggccat aaggatgtgg tcgaggttct tctgaggaac gatgcgctga ccaacgtggc      540

tgactcaaaa ggctgctacc ctctgcattt ggcagcctgg aaaggagatg cccagatagt      600

gcggttgctc atccatcaag ggccttcaca caccagagtc aatgaacaga acaatgacaa      660

cgagacagcc ctgcattgtg cagcgcagta tggccacaca gaggtggtga aggtgctctt      720

agaggagctg acggacccca ccatgcgcaa caacaaattc gagacccctt tggacctggc      780

agcactgtac gggcgactgg aggtggtgaa aatgctcctt aatgcacacc ccaacctcct      840

gagctgcaac actaagaagc acacccctct gcacttggca gcaaggaatg gccacaaagc      900

cgtggtccag gtcctcctcg atgctggcat ggacagcaac taccagacgg agatgggcag      960

tgctttgcat gaggctgctt tgtttggcaa gaccgatgtg gtgcaaatcc tgctggctgc     1020

aggaactgac gtcaacataa aagataacca tggactgact gccctagaca ctgttcggga     1080

actgccttct caaaagagcc agcaaatagc agcattaatt gaagatcaca tgactggaaa     1140

aagaagtaca aaagaagtag ataaaacccc cccaccccag ccacctctca tctccagtat     1200

ggactccata tcacagaagt ctcagggtga cgtggagaaa gcagtgactg aactgattat     1260

agattttgat gcaaatgctg aagaagaggg tccctacgaa gctctgtata atgccatctc     1320

ctgccattcg ttggacagca tggccagcgg gcgatcatct gaccaagact ccacgaacaa     1380

ggaggctgag gcagcaggag tgaaacctgc tggagtgagg cctagggaac gtccaccacc     1440

tccagcaaag ccaccgcccg atgaagagga agaagaccac atagataaga agtattttcc     1500

cttgacagct tctgaggttc tgtccatgag acctaggatt catgggagtg cagcccggga     1560

agaagacgaa cacccttatg aactgttgtt aacagcagag acaaagaaag tggtgttggt     1620

ggatggaaaa acaaaaggct aagagaactg tcagaagccc atcagtctgg gaagaaaggg     1680

agcttcatgc ctggcctcct tgtggttagg aaggaaaatg gcccacacac ttaccaaatt     1740

aaggggctac tgccacgtgc gtccctgttg aagtgggaca gcacagtgct ctgcacagaa     1800

gccattctcc tgaaagagat tgagaaaatc atgagttcta ttggagaagg gattgacttt     1860

tctcaggaac ggcagaagat ctcaggttta cggacgctgg agcagagtgt cggggagtgg     1920

ctggagtcga ttgggctgca gcagtatgag agcaagttgc ttctgaatgg ctttgacgat     1980

gtccacttcc tggggtctaa tgtgatggaa gagcaggacc tgcgggacat cggcatcagc     2040

gacccacagc accggcggaa gctgctccag gcggcacgct ccctacccaa ggtgaaggct     2100

ctgggttatg acgggaacag cccccctagc gtgccctcct ggctggactc cctggggctg     2160

caggactacg tccattcctt cttgtcaagt ggttacagct ccattgacac cgtgaagaac     2220

ctctgggagc tagagctcgt caatgtcctg aaggtccagc tgctcggcca tcgcaagcgc     2280

atcatcgcct ccctcgcaga cagaccgtac gaggagccgc cccagaagcc ccccagattc     2340

tcccagctga ggtgccaaga tttgctctcc cagacgtcat ccccactgag tcagaatgat     2400

tcctgcactg ggcggtcggc agatctgctg ctgcctccag gggacacagg caggaggcgc     2460

catgacagtc tccatgaccc tgcggcaccc tcccgagcgg agcgcttcag gatccaggag     2520

gagcaccgtg aggccaagct gaccctgcgg cccccgagcc tggcagcccc ctacgcccca     2580

gtgcagagtt ggcaacacca gccagagaaa ctcatcttcg agtcctgtgg ttatgaagcc     2640

aattatctgg gctccatgct gatcaaagat ctgcgaggga cagaatccac gcaagacgcc     2700

tgtgccaaga tgcggaaatc tacggagcac atgaagaaga tccccaccat catcctgtcc     2760

atcacataca aaggtgtcaa gttcatcgat gcctccaaca agaacgtcat tgcagagcac     2820

gagatccgga acatttcctg tgcggcccag gacccggagg acctctgtac ctttgcctac     2880

atcaccaagg acctgcagac cagccaccac tattgccatg tgttcagcac cgtggatgtg     2940

aacctgacct acgagatcat cctgacgctg gggcaggcct tcgaagtggc ctatcagttg     3000

gccctgcagg cccagaagtc cagggcgacg ggcgcctctg cagctgagat gattgaaaca     3060

aaatcttcca aaccggtgcc taagcctcgg gtcggcgtga ggaaatccgc agtgccgctg     3120

ccccccgata gtcgctgttg ttactgtcac acctgcacca cccaccgtcc ttcctaccta     3180

ccgctgccat ctgttagtcc tggagtcaag ctggaaccac ctgatatgga ccaagatgcc     3240

caatcccatg ccagtgtctc ctgggttgtg gaccccaaac cagactctaa gcggagcctc     3300

agcaccaacc atactaggtt ggagctggtc tgctgcagtc agcctgaaaa tgagttggtc     3360

tctacaatct caggagacaa gcccaaatcc ttcctagaac ctctcttatt tgtgatgcca     3420

acaacagctt acaaccacaa ctgcccagaa tggagaagcc agaaggatgg aggctgctcc     3480

acctctgaat gcccacatca cctctgcctg gaaaaaccgg gtgttctaag cttagagatg     3540

agggaaagga gacttactgg gctagagaac aggaccagaa taaacttgat acaagtgagt     3600

cac                                                                   3603


<210> 1885
<211> 1997
<212> DNA
<213> Homo sapiens

<400> 1885
tgagcaaccc taattaacct gattttttgc tgataatcac tctcaatgga atcaaatcac       60

aaatccgggg atggattgag cggcactcag aaggaagcag ccctccgcgc actggtccag      120

cgcacaggat atagcttggt ccaggaaaat ggacaaagaa aatatggtgg ccctccacct      180

ggttgggatg ctgcaccccc tgaaaggggc tgtgaaattt ttattggaaa acttccccga      240

gacctttttg aggatgagct tataccatta tgtgaaaaaa tcggtaaaat ttatgaaatg      300

agaatgatga tggattttaa tggcaacaat agaggatatg catttgtaac attttcaaat      360

aaagtggaag ccaagaatgc aatcaagcaa cttaataatt atgaaattag aaatgggcgc      420

ctcttagggg tttgtgccag tgtggacaac tgccgattat ttgttggggg catcccaaaa      480

accaaaaaga gagaagaaat cttatcggag atgaaaaagg ttactgaagg tgttgtcgat      540

gtcatcgtct acccaagcgc tgcagataaa accaaaaacc gaggctttgc cttcgtggag      600

tatgagagtc atcgagcagc tgccatggcg aggaggaaac tgctaccagg aagaattcag      660

ttatggggac atggtattgc agtagactgg gcagagccag aagtagaagt tgatgaagat      720

acaatgtctt cagtgaaaat cctatatgta agaaatctta tgctgtctac ctctgaagag      780

atgattgaaa aggaattcaa caatatcaaa ccaggtgctg tggagagggt gaagaaaatt      840

cgagactatg cttttgtgca cttcagtaac cgagaagatg cagttgaggc tatgaaagct      900

ttaaatggca aggtgctgga tggttccccc attgaagtca ccctagcaaa accagtggac      960

aaggacagtt atgttaggta tacccgaggc acaggtggaa ggggcaccat gctgcaagga     1020

gagtatacct actctttggg ccaagtttat gatcccacca caacctacct tggagctcct     1080

gtcttctatg ccccccagac ctatgcagca attcccagtc ttcatttccc agccaccaaa     1140

ggacatctca gcaacagagc cattatccga gccccttctg ttagagaaat ttacatgaat     1200

gtacctgtag gggctgcggg agtgagagga ctgggcggcc gtggctattt ggcatacaca     1260

ggcctgggtc gaggatacca ggtcaaagga gacaaaagag aagacaaact ctatgacatt     1320

ttacctggga tggagctcac cccaatgaat cctgtcacat taaaacccca aggaattaaa     1380

ctcgctcccc agatattaga agagatttgt cagaaaaata actggggaca gccagtgtac     1440

cagctgcact ctgctattgg acaagaccaa agacagctat tcttgtacaa aataactatt     1500

cctgctctag ccagccagaa tcctgcaatc caccctttca cacctccaaa gctgagtgcc     1560

tttgtggatg aagcaaagac gtatgcagcc gaatacaccc tgcagaccct gggcatcccc     1620

actgatggag gcgatggcac catggctact gctgctgctg ctgctactgc tttcccagga     1680

tatgctgtcc ctaatgcaac tgcacccgtg tctgcagccc agctcaagca agcggtaacc     1740

cttggacaag acttagcagc atatacaacc tatgaggtct acccaacttt tgcagtgact     1800

gcccgagggg atggatatgg caccttctga agatgctttt ttaaatttaa gaataagaca     1860

cacaaaactc tattaaaaaa aaaaaagaaa taaacctcta actcggtccc caatgatcat     1920

aaataatatg tttcctaaag aaatgccttt ccagagactg tatagcttat accaattata     1980

gaatcatgaa gtaagaa                                                    1997


<210> 1886
<211> 2211
<212> DNA
<213> Homo sapiens

<400> 1886
tttgatatga cgattagagc ataacccgag tgacacgttg aattcgccat aatcaaggaa       60

accttttccg ggtggggatc tctgaaatta ctcagtgagc aaccctaatt aacctgattt      120

tttgctgata atcactctca atggaatcaa atcacaaatc cggggatgga ttgagcggca      180

ctcagaagga agcagccctc cgcgcactgg tccagcgcac aggatatagc ttggtccagg      240

aatttagagg ttcctataga tggaagcagt gtgtctgggc acatgcccag agccagaagc      300

gagcatgagc acagcaattc ctggcctcaa aaaaggaaat aatgctttgc agtccatcat      360

tttgcaaact ttgctggaaa aggaaaatgg acaaagaaaa tatggtggcc ctccacctgg      420

ttgggatgct gcaccccctg aaaggggctg tgaaattttt attggaaaac ttccccgaga      480

cctttttgag gatgagctta taccattatg tgaaaaaatc ggtaaaattt atgaaatgag      540

aatgatgatg gattttaatg gcaacaatag aggatatgca tttgtaacat tttcaaataa      600

agtggaagcc aagaatgcaa tcaagcaact taataattat gaaattagaa atgggcgcct      660

cttaggggtt tgtgccagtg tggacaactg ccgattattt gttgggggca tcccaaaaac      720

caaaaagaga gaagaaatct tatcggagat gaaaaaggtt actgaaggtg ttgtcgatgt      780

catcgtctac ccaagcgctg cagataaaac caaaaaccga ggctttgcct tcgtggagta      840

tgagagtcat cgagcagctg ccatggcgag gaggaaactg ctaccaggaa gaattcagtt      900

atggggacat ggtattgcag tagactgggc agagccagaa gtagaagttg atgaagatac      960

aatgtcttca gtgaaaatcc tatatgtaag aaatcttatg ctgtctacct ctgaagagat     1020

gattgaaaag gaattcaaca atatcaaacc aggtgctgtg gagagggtga agaaaattcg     1080

agactatgct tttgtgcact tcagtaaccg agaagatgca gttgaggcta tgaaagcttt     1140

aaatggcaag gtgctggatg gttcccccat tgaagtcacc ctagcaaaac cagtggacaa     1200

ggacagttat gttaggtata cccgaggcac aggtggaagg ggcaccatgc tgcaaggaga     1260

gtatacctac tctttgggcc aagtttatga tcccaccaca acctaccttg gagctcctgt     1320

cttctatgcc ccccagacct atgcagcaat tcccagtctt catttcccag ccaccaaagg     1380

acatctcagc aacagagcca ttatccgagc cccttctgtt agaggggctg cgggagtgag     1440

aggactgggc ggccgtggct atttggcata cacaggcctg ggtcgaggat accaggtcaa     1500

aggagacaaa agagaagaca aactctatga cattttacct gggatggagc tcaccccaat     1560

gaatcctgtc acattaaaac cccaaggaat taaactcgct ccccagatat tagaagagat     1620

ttgtcagaaa aataactggg gacagccagt gtaccagctg cactctgcta ttggacaaga     1680

ccaaagacag ctattcttgt acaaaataac tattcctgct ctagccagcc agaatcctgc     1740

aatccaccct ttcacacctc caaagctgag tgcctttgtg gatgaagcaa agacgtatgc     1800

agccgaatac accctgcaga ccctgggcat ccccactgat ggaggcgatg gcaccatggc     1860

tactgctgct gctgctgcta ctgctttccc aggatatgct gtccctaatg caactgcacc     1920

cgtgtctgca gcccagctca agcaagcggt aacccttgga caagacttag cagcatatac     1980

aacctatgag gtctacccaa cttttgcagt gactgcccga ggggatggat atggcacctt     2040

ctgaagatgc ttttttaaat ttaagaataa gacacacaaa actctattaa aaaaaaaaaa     2100

gaaataaacc tctaactcgg tccccaatga tcataaataa tatgtttcct aaagaaatgc     2160

ctttccagag actgtatagc ttataccaat tatagaatca tgaagtaaga a              2211


<210> 1887
<211> 2116
<212> DNA
<213> Homo sapiens

<400> 1887
tttgatatga cgattagagc ataacccgag tgacacgttg aattcgccat aatcaaggaa       60

accttttccg ggtggggatc tctgaaatta ctcagataac agtgctgtgc caaaaacctg      120

tggattttct ctacaaaaat tattgagcaa ccctaattaa cctgattttt tgctgataat      180

cactctcaat ggaatcaaat cacaaatccg gggatggatt gagcggcact cagaaggaag      240

cagccctccg cgcactggtc cagcgcacag gatatagctt ggtccaggaa aatggacaaa      300

gaaaatatgg tggccctcca cctggttggg atgctgcacc ccctgaaagg ggctgtgaaa      360

tttttattgg aaaacttccc cgagaccttt ttgaggatga gcttatacca ttatgtgaaa      420

aaatcggtaa aatttatgaa atgagaatga tgatggattt taatggcaac aatagaggat      480

atgcatttgt aacattttca aataaagtgg aagccaagaa tgcaatcaag caacttaata      540

attatgaaat tagaaatggg cgcctcttag gggtttgtgc cagtgtggac aactgccgat      600

tatttgttgg gggcatccca aaaaccaaaa agagagaaga aatcttatcg gagatgaaaa      660

aggttactga aggtgttgtc gatgtcatcg tctacccaag cgctgcagat aaaaccaaaa      720

accgaggctt tgccttcgtg gagtatgaga gtcatcgagc agctgccatg gcgaggagga      780

aactgctacc aggaagaatt cagttatggg gacatggtat tgcagtagac tgggcagagc      840

cagaagtaga agttgatgaa gatacaatgt cttcagtgaa aatcctatat gtaagaaatc      900

ttatgctgtc tacctctgaa gagatgattg aaaaggaatt caacaatatc aaaccaggtg      960

ctgtggagag ggtgaagaaa attcgagact atgcttttgt gcacttcagt aaccgagaag     1020

atgcagttga ggctatgaaa gctttaaatg gcaaggtgct ggatggttcc cccattgaag     1080

tcaccctagc aaaaccagtg gacaaggaca gttatgttag gtatacccga ggcacaggtg     1140

gaaggggcac catgctgcaa ggagagtata cctactcttt gggccaagtt tatgatccca     1200

ccacaaccta ccttggagct cctgtcttct atgcccccca gacctatgca gcaattccca     1260

gtcttcattt cccagccacc aaaggacatc tcagcaacag agccattatc cgagcccctt     1320

ctgttagagg ggctgcggga gtgagaggac tgggcggccg tggctatttg gcatacacag     1380

gcctgggtcg aggataccag gtcaaaggag acaaaagaga agacaaactc tatgacattt     1440

tacctgggat ggagctcacc ccaatgaatc ctgtcacatt aaaaccccaa ggaattaaac     1500

tcgctcccca gatattagaa gagatttgtc agaaaaataa ctggggacag ccagtgtacc     1560

agctgcactc tgctattgga caagaccaaa gacagctatt cttgtacaaa ataactattc     1620

ctgctctagc cagccagaat cctgcaatcc accctttcac acctccaaag ctgagtgcct     1680

ttgtggatga agcaaagacg tatgcagccg aatacaccct gcagaccctg ggcatcccca     1740

ctgatggagg cgatggcacc atggctactg ctgctgctgc tgctactgct ttcccaggat     1800

atgctgtccc taatgcaact gcacccgtgt ctgcagccca gctcaagcaa gcggtaaccc     1860

ttggacaaga cttagcagca tatacaacct atgaggtcta cccaactttt gcagtgactg     1920

cccgagggga tggatatggc accttctgaa gatgcttttt taaatttaag aataagacac     1980

acaaaactct attaaaaaaa aaaaagaaat aaacctctaa ctcggtcccc aatgatcata     2040

aataatatgt ttcctaaaga aatgcctttc cagagactgt atagcttata ccaattatag     2100

aatcatgaag taagaa                                                     2116


<210> 1888
<211> 2068
<212> DNA
<213> Homo sapiens

<400> 1888
tttgatatga cgattagagc ataacccgag tgacacgttg aattcgccat aatcaaggaa       60

accttttccg ggtggggatc tctgaaatta ctcagtgagc aaccctaatt aacctgattt      120

tttgctgata atcactctca atggaatcaa atcacaaatc cggggatgga ttgagcggca      180

ctcagaagga agcagccctc cgcgcactgg tccagcgcac aggatatagc ttggtccagg      240

aaaatggaca aagaaaatat ggtggccctc cacctggttg ggatgctgca ccccctgaaa      300

ggggctgtga aatttttatt ggaaaacttc cccgagacct ttttgaggat gagcttatac      360

cattatgtga aaaaatcggt aaaatttatg aaatgagaat gatgatggat tttaatggca      420

acaatagagg atatgcattt gtaacatttt caaataaagt ggaagccaag aatgcaatca      480

agcaacttaa taattatgaa attagaaatg ggcgcctctt aggggtttgt gccagtgtgg      540

acaactgccg attatttgtt gggggcatcc caaaaaccaa aaagagagaa gaaatcttat      600

cggagatgaa aaaggttact gaaggtgttg tcgatgtcat cgtctaccca agcgctgcag      660

ataaaaccaa aaaccgaggc tttgccttcg tggagtatga gagtcatcga gcagctgcca      720

tggcgaggag gaaactgcta ccaggaagaa ttcagttatg gggacatggt attgcagtag      780

actgggcaga gccagaagta gaagttgatg aagatacaat gtcttcagtg aaaatcctat      840

atgtaagaaa tcttatgctg tctacctctg aagagatgat tgaaaaggaa ttcaacaata      900

tcaaaccagg tgctgtggag agggtgaaga aaattcgaga ctatgctttt gtgcacttca      960

gtaaccgaga agatgcagtt gaggctatga aagctttaaa tggcaaggtg ctggatggtt     1020

cccccattga agtcacccta gcaaaaccag tggacaagga cagttatgtt aggtataccc     1080

gaggcacagg tggaaggggc accatgctgc aaggagagta tacctactct ttgggccaag     1140

tttatgatcc caccacaacc taccttggag ctcctgtctt ctatgccccc cagacctatg     1200

cagcaattcc cagtcttcat ttcccagcca ccaaaggaca tctcagcaac agagccatta     1260

tccgagcccc ttctgttaga ggggctgcgg gagtgagagg actgggcggc cgtggctatt     1320

tggcatacac aggcctgggt cgaggatacc aggtcaaagg agacaaaaga gaagacaaac     1380

tctatgacat tttacctggg atggagctca ccccaatgaa tcctgtcaca ttaaaacccc     1440

aaggaattaa actcgctccc cagatattag aagagatttg tcagaaaaat aactggggac     1500

agccagtgta ccagctgcac tctgctattg gacaagacca aagacagcta ttcttgtaca     1560

aaataactat tcctgctcta gccagccaga atcctgcaat ccaccctttc acacctccaa     1620

agctgagtgc ctttgtggat gaagcaaaga cgtatgcagc cgaatacacc ctgcagaccc     1680

tgggcatccc cactgatgga ggcgatggca ccatggctac tgctgctgct gctgctactg     1740

ctttcccagg atatgctgtc cctaatgcaa ctgcacccgt gtctgcagcc cagctcaagc     1800

aagcggtaac ccttggacaa gacttagcag catatacaac ctatgaggtc tacccaactt     1860

ttgcagtgac tgcccgaggg gatggatatg gcaccttctg aagatgcttt tttaaattta     1920

agaataagac acacaaaact ctattaaaaa aaaaaaagaa ataaacctct aactcggtcc     1980

ccaatgatca taaataatat gtttcctaaa gaaatgcctt tccagagact gtatagctta     2040

taccaattat agaatcatga agtaagaa                                        2068


<210> 1889
<211> 2003
<212> DNA
<213> Homo sapiens

<400> 1889
ggaagacatc aggatgtacc atctgccctt ctgtcggacc ccagggtacg tcccatgagc       60

gcggccgagc tgcgtcgagg gcagcagagc gtgctgcact gctcagggac ccggactctg      120

cagtttctcc tgcactgttt tcacctttgg ccagacgggc tctgggaaga cctacaccct      180

gactggaccc cctccccagg gggagggggt gcctgtaccc cccagcctgg ctggcatcat      240

gcagaggacc ttcgcctggc tgttggaccg cgtgcagcac ctgggtgccc ctgtcaccct      300

tcgcgcctct tatctggaga tctacaatga gcaggttcgg gacttgctga gcctggggtc      360

tccccggccc ctccctgttc gctggaacaa gactcggggc ttctatgtgg agcagctgcg      420

ggtggtggaa tttgggagtc tggaggccct gatggaactt ttgcaaacgg gtctcagccg      480

tcgaaggaac tcagcccaca ccctgaacca ggcctccagc cgaagccatg ccctgctcac      540

cctttacatc agccgtcaaa ctgcccagca gatgccttct gtggaccctg gggagccccc      600

tgttggtggg aagctgtgct ttgtggacct ggcaggcagt gagaaggtag cagccacggg      660

atcccgtggg gagctgatgc ttgaggctaa cagcatcaac cgaagcctgc tggccctggg      720

tcactgcatc tccctgctgc tggacccaca gcggaagcag agccacatcc ctttccggga      780

cagcaagctc accaagttgc tggcagactc actgggaggg cgcggggtca ccctcatggt      840

ggcctgcgtg tccccctcag cccagtgcct tcctgagact ctcagcaccc tgcgatatgc      900

aagccgagct cagcgggtca ccacccgacc acaggccccc aagtctcctg tggcaaagca      960

gccccagcgt ttggagacag agatgctgca gctccaggag gagaaccgtc gcctgcagtt     1020

ccagctggac caaatggact gcaaggcctc agggctcagt ggagcccggg tggcctgggc     1080

ccagcggaac ctgtacggga tgctacagga gttcatgcta gagaatgaga ggctcaggaa     1140

agaaaagagc cagctgcaga atagccgaga cctggcccag aatgagcagc gcatcctggc     1200

ccagcaggtc catgcactag agaggcgtct cctctctgcc tgctaccatc accagcaggg     1260

tcctggcctg accccaccgt gtccctgctt gatggcccca gctccccctt gccatgcact     1320

gccacccctc tactcctgcc cctgctgcca catctgccca ctgtgtcgag tgcccctggc     1380

ccactgggcc tgcctgccag gggagcacca cctgccccag gtgttggacc ctgaggcctc     1440

aggtggcagg cccccatctg cccggccccc accctgggca cccccatgca gccctggctc     1500

tgccaagtgc ccaagagaga ggagtcacag tgactggact cagacccgag tcctggcaga     1560

gatgttgacg gaggaggagg tggtaccttc tgcacctccc ctgcctgtga ggcccccgaa     1620

gacatcacca gggctcagag gtggggccgg ggttccaaac ctggcccaga gactggaggc     1680

cctcagagac cagattggca gctccctgcg acgtggccgc agccagccac cctgcagtga     1740

gggcgcacgg agcccaggcc aagtcctccc tccccattga aggccaagtg ggaacccagg     1800

agactgctgt gtgacctcag actgggctcc acactcttgg gcttcagtct gcccatctgc     1860

tgaatggaga cagcagctgc tactccacct gcagctgggc taggggcggg gactgggggt     1920

gctatttagg ggaacaaggg gattcaggag aaaccaggca gcaggggatg aaatacatga     1980

ataaagagag gcatcagctc caa                                             2003


<210> 1890
<211> 1617
<212> DNA
<213> Homo sapiens

<400> 1890
tttttcatga tttttcctca cactgatcac tatccaatca gaacaataaa cttctaacac       60

tcccttacta aaagaacatg gttaagggtg agaaaggccc caagggcaag aagatcaccc      120

tcaaggtggc caggaattgc atcaaaatca cttttgatgg gaaaaagcgc cttgacttga      180

gcaagatggg aattaccacc ttccccaagt gtattctgcg ccttagtgac atggacgagc      240

tggaccttag ccggaatctt atcaggaaga tccctgactc catctccaag ttccagaacc      300

tccggtggct ggacctgcac agcaactaca tagacaagct gcctgagtcc attggccaga      360

tgaccagcct gctctacctc aacgtcagca acaaccggct gaccagcaac gggctgcccg      420

tggagctgaa gcaactcaag aacatccgcg ctgtgaacct aggcttgaac cacctggaca      480

gcgtgcccac cacactgggg gccctgaagg agctccacga ggtagggctc catgacaacc      540

tactgaacaa catccccgtg agcatctcca agctccccaa gctgaaaaag ctcaacataa      600

agcggaaccc ctttccaaag ccaggtgagt cggaaatatt catagactcc atcaggaggc      660

tggagaactt gtatgttgtg gaggagaagg atctgtgtgc ggcttgcctg agaaaatgcc      720

aaaacgcccg ggacaacctg aatagaatca agaacatggc cacgacgaca ccgagaaaga      780

ccatctttcc caatctgatc tcacccaatt ccatggccaa ggactcctgg gaagactgga      840

gaatacgctt gacatcttcc tagagtagct gtggcaaaat cttgaagact actcagctaa      900

cagaataaac gactctgaag aggagaagcc cccagttagg agaagacaga gtggcaagtg      960

agatgttctg gaaaccaggc tcgccggagc tggccaagcc accgacttgc ttctcaaatt     1020

cacttcacct cccttagctt tagcccacct gtgtgtgaaa atgactttgg gaaatatttg     1080

atgtggtttt taaaatgtat atagaaaaaa atttaagaaa attacagatt atatattata     1140

gacaactaaa tatttaagac tttaagactt aaaaggctta ctgcctctac atttcactca     1200

gactagtaca tctcaatgcc agtagtctgt gataaattta tgtaggtata atgagatact     1260

gatatggttt gggcatttgt ctcctccaaa cctcatgttg agatttgatc cccagtgttg     1320

gaggtggggc ctaatggaag gtcatggggg tgggtccctc atgaatggcc tggtgccatc     1380

cttttggtaa tgagtgagtt ctcactgtat tagatcctgt tgaaaattga ttgttaaaaa     1440

gaccttggca cctccctctc ctctctctct cttcctctca ctatgtgatg cctgctcccc     1500

ttcaccttcc accatgagtg gaagcaccta taccccaaag ccctcaccag aaggaggtgc     1560

cggcacctgt acagcttgta agaaccatga ctcaaataaa cttcttttct ttataaa        1617


<210> 1891
<211> 2380
<212> DNA
<213> Homo sapiens

<400> 1891
gatgctccaa atatccctac aaagtacttt attattcctg tttcacagac aaggaaactg       60

gggcacagac aggttgaaca atgttcctgt agctgagcca ggatttgaac ccagggattt      120

atttctctac aagggacaca ggtgactgaa cttcctcctg gccccgagga cccagggaag      180

cacctctttg agatcagccc aggtggtgcc ggggagcggg agaaggtgcc ggccaacccc      240

gaggcgctcc tgctcatggc cagctcccag cgtgacatgg aggactgggt gcaggccatc      300

cgccgagtca tctgggcccc gctgggcgga ggtactgccc gtagatcgca tgcccaccct      360

ctagaaccct tgcctccagg gatctttggg cagcgcctag aggaaacagt ccaccacgag      420

cggaagtatg gcccccgcct ggcgcccctg ctggtggagc agtgtgtgga cttcatccgg      480

gagcgcgggc tcactgagga ggggctgttc cgcatgccag gccaggccaa cctggtgagg      540

gacctgcagg attccttcga ctgtggggag aagccactgt ttgacagcac aacagacgtg      600

cacacggtgg cctccctgct gaagctgtac ctgcgggagc tccccgagcc cgtggtcccc      660

ttcgccaggt acgaggactt cctcagctgc gcccagctgc tcaccaagga cgagggggag      720

ggcactctgg agttggctaa acaagtgagc aaccttcctc aggcaaatta caacctgctc      780

agatacatct gcaagtttct ggatgaagtt caggcatact caaatgtcaa caagatgagt      840

gtccagaatc tggcaaccgt ttttggacct aacattctgc ggccacaggt agaggaccca      900

gtaaccatca tggaaggcac ttccctcgtc cagcacctga tgaccgtcct catccgcaaa      960

cacagccagc tcttcacggc accggtcccg gaagggccca cctccccgcg cgggggcctg     1020

caatgcgcag tggggtgggg ctccgaggag gtcaccaggg acagccaagg agagcccggc     1080

ggccccggcc tgcccgcgca caggacctct tccctggacg gggcggccgt ggcggtgctc     1140

tccagaacag cccccacggg gccggggagc cggtgcagcc ctgggaagaa ggtgcagacc     1200

ctgcccagtt ggaagtcctc cttccggcag ccgaggtccc tatcgggaag cccgaagggg     1260

ggcggctcat ccctggaggt gcccatcatc tcctccggcg ggaactggct tatgaacggg     1320

ctgtcctccc tgcgcggaca ccgccgggcc tcgtcgggag accggctcaa ggactcgggc     1380

tccgtgcaga gactctccac ctacgacaat gtgcccgcgc cgggcctggt ccccggcata     1440

cccagcgtgg ccagtatggc gtggtccggg gcctcgtcca gcgagtcgtc ggtggggggc     1500

tcactcagca gctgcacggc ctgccgcgcc agcgactcgt ctgcccgcag ttccctgcac     1560

accgactggg ccctggagcc ctccccgctc cccagcagca gcgaggaccc caagtccctg     1620

gacctggacc acagcatgga cgaggcgggc gcgggtgcca gcaacagcga gcccagcgag     1680

ccggacagcc ccacccggga acacgcgcgc cgctccgagg ccttacaggg gctggtcact     1740

gagctcaggg ccgagctgtg ccgccagcgg actgagtacg agaggagtgt gaaaagaatc     1800

gaagaaggga gtgctgacct gagaaaacga atgtcccggt tagaagaaga actggaccag     1860

gaaaagaaaa aatacatcat gctggaaata aagctgcgga actctgaacg ggcgcgggag     1920

gatgcggaga ggaggaacca gctgttgcag agggaaatgg aggagttttt ttcgacccta     1980

ggaagcttga ctgttggggc aaaaggtgcc agggccccaa agtaaaagga atggcagagc     2040

tcacttctgt accacgtctg ctggtctcca gccttgtatg gagttagaag cgtctgtatc     2100

tctggagcag ccaggcgctc tggagccagc tggagagaga gagatcctga tacctctgtg     2160

gggactgtgg ggacttttgg gaccccacac actccaggtg ggatcagatg ctgctccaac     2220

catgcagttc ctggtgaggg tcagaagggg acggtaccaa gagtagcgct tagcccttac     2280

ccaggaaata tccttcatgg ccacagaaat ggagggcgcc caggatccag gcagccaccg     2340

ggaacagtca gctttcttta ttaaatgtgc tcacaaagca                           2380


<210> 1892
<211> 2339
<212> DNA
<213> Homo sapiens

<400> 1892
acctgcgaca ggtggagcgc acggggcggg cgcacggcca tgtccgccga gggcgcggag       60

ccggggccgg ggtccgggtc cgggcccggg ccggggccac tctgccccga acacggccag      120

gctctgagct ggttctgcgg ctccgagcga cggcccgtgt gcgccgcctg cgcggggttg      180

ggcggtcgct gccgggggca ccgcatccgc cgggcggagg agcgcgccga ggagctgcgg      240

aacaagattg tggaccagtg tgagaggctg cagttacaga gtgctgccat caccaagtat      300

gtggcggacg tcctgccggg gaagaatcaa agagcagtga gcatggccag tgcagcgagg      360

gaactggtta tccagcggtt gagtctggtg aggagtcttt gcgagagcga ggagcagcgg      420

ttactggaac aggtgcatgg cgaagaggag cgggcccacc agagcatcct gacacagcgg      480

gtgcactggg ccgaggcgct gcagaaactt gacaccatcc gcactggcct ggtgggcatg      540

cttactcacc tggatgacct ccagctgatt cagaaggagc aagagatttt cgagaggacc      600

gaagaagcag agggcatttt ggatccccag gagtcggaaa tgttaaactt taatgagaag      660

tgcactcgga gcccactact gacccaactc tgggcaacgg cggttcttgg gtctctctca      720

ggcacagagg acatacggat cgatgagagg acagtcagcc ccttcctgca attgtcagat      780

gatcgaaaga ccctgacctt cagcaccaag aagtcaaagg cctgtgcaga tggcccggag      840

cgcttcgacc actggcccaa tgccctggct gccacctcct tccagaatgg gctccatgcc      900

tggatggtga atgtccagaa cagttgtgcc tataaggtgg gcgtggcttc aggccacctg      960

ccccgcaagg gttctggcag tgactgccgt ctgggccaca atgccttctc ctgggtcttc     1020

tctcgctatg atcaggagtt tcgtttctca cacaatgggc agcacgagcc cctggggctg     1080

ctgcggggcc cagcccagct gggtgtagtg ctggacttgc aggttcagga gctgctcttc     1140

tatgagccag cctccggcac agtgctctgt gcccatcatg tgtccttccc ggggcccctc     1200

ttcccagtct ttgctgtggc cgatcagacc atttctatcg tccgctgacc tctggccaca     1260

ggaagccagg tccaccgccc accacccttt caggccatgt ttctactcag tgtgcttttc     1320

ccaaatgatg tgtgtggtgt ttctaagaga aacagggccc ataaccagtg ggcagcttta     1380

ggagggatgg ggatctgttt cagatctagg cataacctgt aaatcacagg tgtccaaact     1440

tttggcttcc ctgggccaca tttgaagaag aattttcttg ggccacataa aatacactaa     1500

cgatagctga tgagctaaaa aaaaaaaaaa agtctgtgta taatttttgt gatatctgcc     1560

accacagata agcaaaaaag tccttgcatt caaagggttg gagattgctg ctttgagtgc     1620

tgggtacctg tggggaacct actactccct gggccttagt ctcccaaatc caccatgcat     1680

ctgcccctct gagggtgtct tcactttgtc tctggcatct agcatggtgc ctggtgcata     1740

gtgagcatgc aataaatatt tggcaggtga gtggatggat agatggatag gtgaatgtag     1800

gtggacaggt gactgggtgg atgttgtggt ctctggagaa gcactgccat tcagcctcct     1860

gctccagctg ttcacatgca gaaatgctct cttcacaggc agagaagcct gtggctaaag     1920

tttccacatc ccattaactc agtgcttttg tctttttcat gacatggcac atagagaaaa     1980

tatttttttc tagcacacaa gagcaacctg aaaggctgct cctggccaga ggactctgtc     2040

ccgggggacc gtgtcctccc ccatgtcctg cctaggccct cagaggacca ggggatcatg     2100

tctccaggta acccgactgt agcccctgct ggctgagctc cagcctgtgc ccactgataa     2160

tagcagggac ggccttttct cttagagcag ctgataagtt tccctacctg atggccccct     2220

ctgacataaa ctgcacacct ggggtgatgg cttaaagcca gaaagagctg agggagttaa     2280

gagggccaac cttagggcac gtgggcatta ttaaaggtct taaaagcatt gaagattta      2339


<210> 1893
<211> 872
<212> DNA
<213> Homo sapiens

<400> 1893
ggagcatgat ggaagtcgta gtaggaaatg gcgtcgtggc attgaggggc atccctccta       60

gaacctccag gaaaagctcg cggaagacga ggttctgcgg agagagaggc tccaagcagt      120

ctgggaagtg tagtccagtt ggcttagcag tagtttcgtt gggggggagc cgaggttccg      180

ggaaggggct aggccggctt gaaaagagat tatgactgta ccttttaact ttgtagctgg      240

aacacaagaa gtgtttgttt aatgaatgac gtacacattt aagatctgtt tggacgcgga      300

ggataatcct gtgaattgct aatagttcac tgggtttggc ccttagtgtt gacttcagta      360

tgctgagacg gaaaccaaca cgcctagagc taaagcttga tgacattgaa gagtttgaga      420

acattcgaaa ggacctggag acccgtaaga aacagaagga agatgtggaa gttgtaggag      480

gcagtgatgg agaaggagcc attgggctta gcagtgatcc caagagccgg gaacaaatga      540

tcaatgatcg gattggttat aaaccccaac ccaagcccaa taatcgttca tctcaatttg      600

gaagtcttga attttagaga tggattatct tgcatgccag agcgctggaa tggaataaaa      660

tgatggcaga agtacaaacc agatttagag aattgagtgc ttgcagtcaa gcagaatgta      720

cctcctgcag agacaaatct tctgcatgag attactgatg cttcacttgc actctaagct      780

ggaatccaaa ctctggtttg tctcttgaaa atttgactct ataaaactga tctgattttc      840

tgtttttaaa aataaatata tttttggaaa aa                                    872


<210> 1894
<211> 938
<212> DNA
<213> Homo sapiens

<400> 1894
ggctagcggc cctgcgtggg agttcctgac agctggattc tagaagtaga actatgagct       60

cacctttggc ctcccttagc aagacccgaa aagtgcccct gccctcggag cctatgaatc      120

ctgggaggcg aggaatccgc atctatggag atgagcggtg acctaggcat ccctgtctgc      180

agaagatgag gtggacatgt tgagtgatgg gtgtggctca gaagaaaaga tctcagtccc      240

ttcctgctat ggcggcatag gtgcccctgt gagtcggcaa gtccctgcat cccatgactc      300

ggagctgatg gccttcatga cgaggaagtt gtgggacctg gagcagcagg tgaaggccca      360

gactgatgag atactgtcca aggatcagaa gatagcggcc ctagaggacc tggtgcagac      420

cctccggcca cacccagccg aggcaaccct gcagcggcag gaggaactgg agacgatgtg      480

tgtgcagctg cagcggcagg tcagggagat ggagcggttc ctcagtgact atggcctgca      540

gtgggtgggc gagcccatgg accaggagga ctcagagagc aagacagtct cagagcatgg      600

cgagagggac tggatgacag ccaagaagtt ctggaagcca ggggactcat tggcgccccc      660

tgaggtggac tttgacaggc tgctggccag cctgcaggat cttagtgagc tggtggtaga      720

gggtgacacc caagtgacac cagtgcccgg cggggcacgg ctgcgtaccc tcgagcccat      780

cccgctgaag ctctaccgga atggcatcat gatgttcgac gggcccttcc agcccttcta      840

cgatccctcc acacagcgct gcctccgaga catattggat ggcttctttc cctcagagct      900

ccagcgactg taccccaatg gggtcccctt taaggtga                              938


<210> 1895
<211> 1846
<212> DNA
<213> Homo sapiens

<400> 1895
agtgcagccc cagccagaag agctggaagg ctgggcggcc aggcccgctg tgtccccagt       60

tttcctgttg gagtccatct gctgtgctct caggagagaa ggctgggtct ctgggagctc      120

acatcctgta tgccctccct ccatgccaag caactttggg gagtcctggc agtggtgcca      180

ggcgttgctc ttacctgtac cataaccagg aggctgatgg ttgctcaggc ctccctcaaa      240

ctagccaatg agaagtgcac gggtcctggt cgcctaggaa accgcgtgac aacaagatgg      300

cggcgctgcg ggacggctag cggccctgcg tgggagttcc tgacagctgg attctagaag      360

tagaactatg agctcacctt tggcctccct tagcaagacc cgaaaagtgc ccctgccctc      420

ggagcctatg aatcctggga ggcgaggaat ccgcatctat ggagatgtcc ctgcatccca      480

tgactcggag ctgatggcct tcatgacgag gaagttgtgg gacctggagc agcaggtgaa      540

ggcccagact gatgagatac tgtccaagga tcagaagata gcggccctag aggacctggt      600

gcagaccctc cggccacacc cagccgaggc aaccctgcag cggcaggagg aactggagac      660

gatgtgtgtg cagctgcagc ggcaggtcag ggagatggag cggttcctca gtgactatgg      720

cctgcagtgg gtgggcgagc ccatggacca ggaggactca gagagcaaga cagtctcaga      780

gcatggcgag agggactgga tgacagccaa gaagttctgg aagccagggg actcattggc      840

gccccctgag gtggactttg acaggctgct ggccagcctg caggatctta gtgagctggt      900

ggtagagggt gacacccaag tgacaccagt gcccggcggg gcacggctgc gtaccctcga      960

gcccatcccg ctgaagctct accggaatgg catcatgatg ttcgacgggc ccttccagcc     1020

cttctacgat ccctccacac agcgctgcct ccgagacata ttggatggct tctttccctc     1080

agagctccag cgactgtacc ccaatggggt cccctttaag gtgagtgact tgcgcaatca     1140

ggtctacctg gaggatggac tggacccctt cccaggcgag ggccgtgtgg tgggcaggca     1200

gctgatgcac aaggccttgg acagggtgga ggagcaccca ggctccagga tgactgctga     1260

gaaatttctg aacaggctcc ccaagtttgt gatccggcaa ggcgaggtga ttgacatccg     1320

gggccccatc agggacacct tgcagaactg ctgcccattg cctgcccgga tccaggagat     1380

tgtggtggag acgcccacct tggccgctga gcgagagagg agccaggagt cacccaacac     1440

gccggcaccc ccgctctcca tgctgcgcat caagtctgag aatggggaac aggccttcct     1500

actgatgatg cagcctgaca acaccattgg ggacgtgcga gctctgctag cgcaggccag     1560

ggtcatggat gcctctgcct ttgagatctt cagcacattc ccgcccaccc tctaccagga     1620

cgatacactc acgctgcagg ctgcaggcct tgtgcccaaa gcagcactgc tgctgcgggc     1680

acgccgagcc ccgaagtcca gcctgaaatt cagtcctggt ccctgtcccg gtcccggtcc     1740

cggccccagt cccggtcccg gtcccggccc cagtcccggt cccggtcccg gccccagtcc     1800

ctgtcctgga cccagtccca gcccccaata aagcacccgc cccctc                    1846


<210> 1896
<211> 2872
<212> DNA
<213> Homo sapiens

<400> 1896
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc       60

ccagtaaacg attatgaggg aaatgactct gaagcagaag acttgaattt cagggagact      120

ttgccttcat caagtcagga aaacacacct agatcaaagg tttttgaaaa taaagttaat      180

tcagagaagg taaaactttc tcttcggaat ttcccacata atgattatga ggatgttttt      240

gaagagcctt cagaaagtgg cagtgatccc agcatgtgga cagccagagg ccccttcaga      300

agagacaggt ggagcagtga ggatgaggag gctgcagggc catcacaggc tctctcccct      360

ctactttctg atacgcgcaa aattgtttct gaaggagaac tagatcagtt ggctcagatt      420

cggccattaa tattcaattt tcatgagcag acagccatca aggattgttt gaaaatcctt      480

gaggaaaaaa cagcagcgta tgatatcatg caggaattta tggctttaga acttaagaat      540

ctgcctggtg agttcaactc tgggaatcaa ccaagcaaca gagaaaaaaa cagataccga      600

gatattcttc catatgattc aacacgcgtt cctcttggaa aaagcaagga ctacatcaat      660

gctagttata ttagaatagt caattgtgga gaagagtatt tttatatcgc tactcaagga      720

ccactgctga gcaccataga tgacttttgg caaatggtgt tggaaaataa ttcaaatgtt      780

attgccatga taaccagaga gatagaaggt ggaattatca aatgctacca ttactggccc      840

atttctctga agaagccatt ggaattgaaa cacttccgtg tattcctgga gaactaccag      900

atacttcaat atttcatcat tcgaatgttt caagttgtgg agaagtccac gggaactagt      960

cactctgtaa aacagttgca gttcaccaag tggccagacc atggcactcc tgcctcagca     1020

gatagcttca taaaatatat tcgttatgca aggaagagcc accttacagg acccatggtt     1080

gttcactgca gtgccggcat aggccggaca ggggtgttcc tatgtgtgga tgtcgtgttc     1140

tgtgccatcg taaagaactg ttcattcaac atcatggata tagtggccca aatgagagaa     1200

caacgttctg gcatggttca aacgaaggag cagtatcact tttgttacga tattgtgctt     1260

gaagttcttc ggaaacttct gactttggat taagaaagac ttctgttgcc tctcacttga     1320

aattaccaag tgggtttgca cctcctcata aagaacatgt ttgcactgtg ctgaagggct     1380

ttgctatgca tacaatctgc tttcttggtt tatcagttta ttttctttct aaaagctccc     1440

tgaagggcaa tatcatttgg cttggggtga tcagtgttta cttattgatc ttgctagaca     1500

atatcaaaat aacttcccac attttccagt gaaacagatg ttacataaaa cgattgcagc     1560

ttggctattt ggttgaaggg attacagagc ccaataaagg atttaaaata tattcattaa     1620

gattttattt ggaaaggtgg ctggagagag ctgaggattt ccaggacttt gtaagttctt     1680

attctgggag aacataaggc caataatcat gacctcttcc aggcattttt aagacagatg     1740

tctattcatg ttctttagct agagcctgta ctttttgctg gcatttgaat aacccagttt     1800

aaaaagagtc cagttagggt ggactaactt tggacacaaa ttggcttcca tttcctacat     1860

tttcatactg ctgccttcct acagctgcta gaccaagacc tgttggtctg ggaagcattt     1920

catggatagg gagagctcct ctcggtgaac agtccaaaac taaaatagat gtttatatag     1980

aaagcccaag aggagatttt tgccatgcct gagttctttc ctatcccacc ctaacactta     2040

acatattact tagtctgctt tgttaaaagc aagtattacc tttaacttgc ctcttactct     2100

ttgcccttta gctaactaat aaagtttgat ataggcatta ttatataatt ctgagtcatt     2160

catggtatat ctcatgtttg atgtattttt caaactaaga tctatgatag ttttttttcc     2220

agagttccat taaatcattt atttccttta ctttctcacc tctgttgaaa catttagaaa     2280

ctggatttgg gaacccaatt ttggaaaacc agattcatag tcatgaaaat ggaaacttcc     2340

atattctgtt tttgaaaaga tgtggccatt attacagtaa ttttattata ggactttgcc     2400

tcgtacaatt aatagtgata ttttggacaa ggagttctgg tgacaagcta tacctaatta     2460

taagctataa aacaatagat atgagtgttt gtacagttta actcaatgga gatcagaata     2520

ttctatgtat tgagaaaatg tttaatatca atctataaat cttgaatttc taagaggctt     2580

attttgttct tttggctgaa tgagtatatt tgaattggtt gaataattaa taattctcat     2640

tgtaaaaata attatatgcc aaaaatatat ttgatgttaa atcaaataga tgattctgtt     2700

tacattgttc atatgaataa taatctgtgt taatttcatt ttgataattg gcctttaata     2760

tttgtatctc taattttatt ttctctctgt tactgtaaaa taatagctat aatgtataac     2820

aattttcttc agaagaattc tatgctatta ttaaaataaa atatttactg tg             2872


<210> 1897
<211> 1792
<212> DNA
<213> Homo sapiens

<400> 1897
aaaccgcgtg acaacaagat ggcggcgctg cgggacggct agcggccctg cgtgtacttt       60

cccaagcacc accaggccaa aggtctctca gttcagagca gaaagccgta tacccagagg      120

agcaggcaga taacagaaac ttccagaaac ctctgtggag acagtggaag aggcaaaagg      180

gagttcctga cagctggatt ctagaagtag aactatgagc tcacctttgg cctcccttag      240

caagacccga aaagtgcccc tgccctcgga gcctatgaat cctgggaggc gaggaatccg      300

catctatgga gatgaagatg aggtggacat gttgagtgat gggtgtggct cagaagaaaa      360

gatctcagtc ccttcctgct atggcggcat aggtgcccct gtgagtcggc aagtccctgc      420

atcccatgac tcggagctga tggccttcat gacgaggaag ttgtgggacc tggagcagca      480

ggtgaaggcc cagactgatg agatactgtc caaggatcag aagatagcgg ccctagagga      540

cctggtgcag accctccggc cacacccagc cgaggcaacc ctgcagcggc aggaggaact      600

ggagacgatg tgtgtgcagc tgcagcggca ggtcagggag atggagcggt tcctcagtga      660

ctatggcctg cagtgggtgg gcgagcccat ggaccaggag gactcagaga gcaagacagt      720

ctcagagcat ggcgagaggg actggatgac agccaagaag ttctggaagc caggggactc      780

attggcgccc cctgaggtgg actttgacag gctgctggcc agcctgcagg atcttagtga      840

gctggtggta gagggtgaca cccaagtgac accagtgccc ggcggggcac ggctgcgtac      900

cctcgagccc atcccgctga agctctaccg gaatggcatc atgatgttcg acgggccctt      960

ccagcccttc tacgatccct ccacacagcg ctgcctccga gacatattgg atggcttctt     1020

tccctcagag ctccagcgac tgtaccccaa tggggtcccc tttaaggtga gtgacttgcg     1080

caatcaggtc tacctggagg atggactgga ccccttccca ggcgagggcc gtgtggtggg     1140

caggcagctg atgcacaagg ccttggacag ggtggaggag cacccaggct ccaggatgac     1200

tgctgagaaa tttctgaaca ggctccccaa gtttgtgatc cggcaaggcg aggtgattga     1260

catccggggc cccatcaggg acaccttgca gaactgctgc ccattgcctg cccggatcca     1320

ggagattgtg gtggagacgc ccaccttggc cgctgagcga gagaggagcc aggagtcacc     1380

caacacgccg gcacccccgc tctccatgct gcgcatcaag tctgagaatg gggaacaggc     1440

cttcctactg atgatgcagc ctgacaacac cattggggac gtgcgagctc tgctagcgca     1500

ggccagggtc atggatgcct ctgcctttga gatcttcagc acattcccgc ccaccctcta     1560

ccaggacgat acactcacgc tgcaggctgc aggccttgtg cccaaagcag cactgctgct     1620

gcgggcacgc cgagccccga agtccagcct gaaattcagt cctggtccct gtcccggtcc     1680

cggtcccggc cccagtcccg gtcccggtcc cggccccagt cccggtcccg gtcccggccc     1740

cagtccctgt cctggaccca gtcccagccc ccaataaagc acccgccccc tc             1792


<210> 1898
<211> 2043
<212> DNA
<213> Homo sapiens

<400> 1898
attattccac aacacccctt gggtgcccca acgcgcctag caccctgtaa gtgctcccca       60

gctgtggata caggtttctc tcagggcagc ccgcaagcag tgcagcccca gccagaagag      120

ctggaaggct gggcggccag gcccgctgtg tccccagttt tcctgttgga gtccatctgc      180

tgtgctctca ggagagaagg ctgggtctct gggagctcac atcctgtatg ccctccctcc      240

atgccaagca actttgggga gtcctggcag tggtgccagg cgttgctctt acctgtacca      300

taaccaggag gctgatggtt gctcaggcct ccctcaaact agccaatgag aagtgcacgg      360

gtcctggtcg cctaggaaac cgcgtgacaa caagatggcg gcgctgcggg acggctagcg      420

gccctgcgtg ggagttcctg acagctggat tctagaagta gaactatgag ctcacctttg      480

gcctccctta gcaagacccg aaaagtgccc ctgccctcgg agcctatgaa tcctgggagg      540

cgaggaatcc gcatctatgg agatgaagat gaggtggaca tgttgagtga tgggtgtggc      600

tcagaagaaa agatctcagt cccttcctgc tatggcggca taggtgcccc tgtgagtcgg      660

caagtccctg catcccatga ctcggagctg atggccttca tgacgaggaa gttgtgggac      720

ctggagcagc aggtgaaggc ccagactgat gagatactgt ccaaggatca gaagatagcg      780

gccctagagg acctggtgca gaccctccgg ccacacccag ccgaggcaac cctgcagcgg      840

caggaggaac tggagacgat gtgtgtgcag ctgcagcggc aggtcaggga gatggagcgg      900

ttcctcagtg actatggcct gcagtgggtg ggcgagccca tggaccagga ggactcagag      960

agcaagacag tctcagagca tggcgagagg gactggatga cagccaagaa gttctggaag     1020

ccaggggact cattggcgcc ccctgaggtg gactttgaca ggctgctggc cagcctgcag     1080

gatcttagtg agctggtggt agagggtgac acccaagtga caccagtgcc cggcggggca     1140

cggctgcgta ccctcgagcc catcccgctg aagctctacc ggaatggcat catgatgttc     1200

gacgggccct tccagccctt ctacgatccc tccacacagc gctgcctccg agacatattg     1260

gatggcttct ttccctcaga gctccagcga ctgtacccca atggggtccc ctttaaggtg     1320

agtgacttgc gcaatcaggt ctacctggag gatggactgg accccttccc aggcgagggc     1380

cgtgtggtgg gcaggcagct gatgcacaag gccttggaca gggtggagga gcacccaggc     1440

tccaggatga ctgctgagaa atttctgaac aggctcccca agtttgtgat ccggcaaggc     1500

gaggtgattg acatccgggg ccccatcagg gacaccttgc agaactgctg cccattgcct     1560

gcccggatcc aggagattgt ggtggagacg cccaccttgg ccgctgagcg agagaggagc     1620

caggagtcac ccaacacgcc ggcacccccg ctctccatgc tgcgcatcaa gtctgagaat     1680

ggggaacagg ccttcctact gatgatgcag cctgacaaca ccattgggga cgtgcgagct     1740

ctgctagcgc aggccagggt catggatgcc tctgcctttg agatcttcag cacattcccg     1800

cccaccctct accaggacga tacactcacg ctgcaggctg caggccttgt gcccaaagca     1860

gcactgctgc tgcgggcacg ccgagccccg aagtccagcc tgaaattcag tcctggtccc     1920

tgtcccggtc ccggtcccgg ccccagtccc ggtcccggtc ccggccccag tcccggtccc     1980

ggtcccggcc ccagtccctg tcctggaccc agtcccagcc cccaataaag cacccgcccc     2040

ctc                                                                   2043


<210> 1899
<211> 1312
<212> DNA
<213> Homo sapiens

<400> 1899
cgctgcggga cggctagcgg ccctgcgtgg aggcgaggaa tccgcatcta tggagatgtc       60

cctgcatccc atgactcgga gctgatggcc ttcatgacga ggaagttgtg ggacctggag      120

cagcaggtga aggcccagac tgatgagata ctgtccaagg atcagaagat agcggcccta      180

gaggacctgg tgcagaccct ccggccacac ccagccgagg caaccctgca gcggcaggag      240

gaactggaga cgatgtgtgt gcagctgcag cggcaggtca gggagatgga ggggactcat      300

tggcgccccc tgaggtggac tttgacaggc tgctggccag cctgcaggat cttagtgagc      360

tggtggtaga gggtgacacc caagtgacac cagtgcccgg cggggcacgg ctgcgtaccc      420

tcgagcccat cccgctgaag ctctaccgga atggcatcat gatgttcgac gggcccttcc      480

agcccttcta cgatccctcc acacagcgct gcctccgaga catattggat ggcttctttc      540

cctcagagct ccagcgactg taccccaatg gggtcccctt taaggtgagt gacttgcgca      600

atcaggtcta cctggaggat ggactggacc ccttcccagg cgagggccgt gtggtgggca      660

ggcagctgat gcacaaggcc ttggacaggg tggaggagca cccaggctcc aggatgactg      720

ctgagaaatt tctgaacagg ctccccaagt ttgtgatccg gcaaggcgag gtgattgaca      780

tccggggccc catcagggac accttgcaga actgctgccc attgcctgcc cggatccagg      840

agattgtggt ggagacgccc accttggccg ctgagcgaga gaggagccag gagtcaccca      900

acacgccggc acccccgctc tccatgctgc gcatcaagtc tgagaatggg gaacaggcct      960

tcctactgat gatgcagcct gacaacacca ttggggacgt gcgagctctg ctagcgcagg     1020

ccagggtcat ggatgcctct gcctttgaga tcttcagcac attcccgccc accctctacc     1080

aggacgatac actcacgctg caggctgcag gccttgtgcc caaagcagca ctgctgctgc     1140

gggcacgccg agccccgaag tccagcctga aattcagtcc tggtccctgt cccggtcccg     1200

gtcccggccc cagtcccggt cccggtcccg gccccagtcc cggtcccggt cccggcccca     1260

gtccctgtcc tggacccagt cccagccccc aataaagcac ccgccccctc aa             1312


<210> 1900
<211> 7622
<212> DNA
<213> Homo sapiens

<400> 1900
gccggcagag accagccggc gggtggcggc ggcccccagc acggccggtg caaggcctcg       60

ggttaagcgg cggccgagcg gggctcggcc cggggtgctc ggggagctcg ccgcggcggg      120

cagcaggagg aagcggcggc ggcgcgtccc gagcggtgcg cgccatggcg ggcgggcccc      180

ccaaggccct gccgtccacg gggccccact ccctgcgcga catgccgcac ccgctggccg      240

gctccagcag cgaggaggcc gtgggtggtg acagcacgcc cagcccggac ctgctgatgg      300

cccgcagctt cggtgacaag gatctcattt tgcccaacgg tggtactcca gcaggtactt      360

caagtccagc ttcttcatct tcccttctca acagacttca gcttgatgat gatattgatg      420

gtgagactag agatctcttc gttatagttg atgatcccaa gaagcatgtg tgtacaatgg      480

agacttacat cacctatagg atcaccacca aaagtactcg ggtggagttt gacctgccag      540

aatattctgt tcgtcgaaga taccaggatt ttgactggtt gaggagcaaa ctggaagaat      600

cccagcccac tcatctcatt ccccctcttc ccgagaagtt tgtggtaaaa ggtgttgtgg      660

atcgtttttc agaagagttt gtggagacca gaagaaaagc tttggataaa tttctaaaaa      720

gaattacgga ccatcctgtg ctgtctttca atgaacactt taatattttc cttactgcta      780

aggacctgaa cgcctacaag aagcaaggga tagcattgct gaccagaatg ggcgagtcag      840

tcaagcacgt cactggcggc tacaagctga ggactcggcc gcttgagttt gctgccatag      900

gtgactactt agatacattt gcactcaaac tgggaaccat tgatcgaata gcccagcgga      960

tcatcaaaga agaaatagag taccttgtgg agctgagaga atacgggcct gtgtactcca     1020

catggagcgc cttggagggt gagctggctg aacccctgga gggtgtgtca gcttgcattg     1080

ggaactgctc tacagcctta gaagagctga cagatgacat gacagaagac ttcctacctg     1140

tgctcaggga atatatttta tactctgact ccatgaagag tgtattgaag aagagggacc     1200

aagttcaagc agagtatgaa gccaaactgg aagctgtggc tctgcggaag gaagaccgcc     1260

ccaaggtacc ggcggacgtc gagaaatgtc aggatcggat ggagtgtttc aatgctgacc     1320

tgaaagctga catggagagg tggcagaaca acaagaggca ggacttccgg cagctactca     1380

tggggatggc tgacaagaac atccagtatt atgagaagtg cctcatggcg tgggagtcga     1440

ttattccact actgcaggag aaacaagagg ccaagtaaag ttctttcttg ggacggagac     1500

tcttctacct acacagggcc tggcacccta taccggaatg tccctgcagt gccagagacg     1560

cagtgctggg aaaacaacca cagaaacatc tctcctttgt gtatttttcc ctcccccacc     1620

tttcacccca cagtggtttt caattagtat ttattccatg gtggagtctg tgaggctaga     1680

atatctctca gcaagagcag catacctcca tgttgtgaag gcatctgttc agtgaagcac     1740

tacgaaaatt tgaaaccaag ggacaagaca acctgcagct gacgctctga catttcatga     1800

cagtttcctc tttagggaca gctgagttgc cagttgtggg agagaacccg gggcctgctt     1860

ttcaaggatg aggaggaggc aggaacagaa ggcagctgct gctttctgtg gaaacctggc     1920

ccctctggaa ttggcctctg tgggcattga ctcgtcttgg cctaggaggc attggtgcct     1980

ccctggcaag tccttaacgt acagtacctg tagctgtgag tgtggcctgc tgcctgcttg     2040

tgatgagtga taccgtctta ctgtttctgt ttcacatagg gacatttaaa tcaatgtcaa     2100

tgtgcgtcca tgcttgagtg agcaagccag cgtccttgtc ctcctgcaat gcctttggga     2160

agctcagggg aatgctcccc aagcttgttt ctgacactag aatgcaacag attggaaact     2220

ttttgtgtaa aatgaaaaaa acaaagtgct ggtttttttt ttttttctgt gaaggtcttc     2280

agtgttttgc ttgttcactg tcatcagagc agggattaga cctgttaggg aatatctatt     2340

gtcttgaagt cagagtagct ccccattgtt gagatcagtg ggcatatacc aagctccacc     2400

cccagtgtca gctttgtgca atttgccttt acctcaccaa aaatacctac tttaatattt     2460

cctcctgtgt cctctgaatg tctgggcgag cttttggtga gagggctggt atgtcatgtt     2520

gttatgatac agtcgaaatt tgtcaatgca gtgtgaatgt tctacataaa gtgctttaac     2580

ccttaacatt tcctggtcag gaaggaaaat cagtacctgg acgggcctcg aaaatgacaa     2640

atgcaacagc gagccctttg tgtccagcta agctaaagtc tcctcagtgt gcagccagat     2700

tcctggggac tgctgagtgt ggttacaggc tgcatttcag acaatgacca ggtttacttt     2760

tcagatcaca aagcaaacag tcaccaagga tctgtcttcc aactcttttt tttttctgct     2820

gaaatgaagc tacatgtcat gtttgtgttc tttcatctgt ggctcatccc tgtaaaacta     2880

cgaatctgag cctcaaataa gcagtagttt ttttgttgtt tatttttaat gaaacagctg     2940

tgttaaggcg ctgcttcaga tgcaagttca cctggaaata ctggtcagcg ggcagcacgt     3000

caaggtcact taagcccact tttaactgca ggtcatcctc gcatcagcca aggctgtggt     3060

gctgttgatg ccgcagttgg acagcatagg acggcttggt tctgtttcat tgtgtttgac     3120

aatgttgcag tttaaatgat aatgtttaaa tcaattggta cttgcctgta gtgttaaacc     3180

ctatttgtgc cattctcaag tcctttgatg tgaattttca gtttggtaca gttagaaatg     3240

actcattgat gcggacaggt aagaacaacc catgtacccc cgagtgattg catgctttat     3300

tctacctcta agccatcgtg ttgacgtggg tatggacgcc tgggtctgac ctgacactgt     3360

gctgggagaa tcaggatgtg tgtctaatgg cgagctgaca gccctctgct gatatttggc     3420

agaaggcacc agaccagccc agcagcaaat gctcatcttt gggaacatag gaagctttac     3480

cttggggaag gtatgcttta caaatgtcca gtgtaatgaa tgtttggaaa aaactggagt     3540

tacaggaaaa tgaaatctga ctatctgcta gttgccaaaa cccagaaaca ttcctgtgta     3600

atggttagtt gggaaagaag gcagcacttg aaaaaattta ccaggttcct cactgggaga     3660

tgtgggaagg ggcgtgggac gcacgcggtc actccctctc ctagtgagag gcagatggct     3720

ggctctgaag ggaggcaggc accgtgggat ttgggcttgc tctgcttggt ccccatgtga     3780

tgccctgtgc tgtaagatat cagaaagacc tggaacaagg caaactttat gtcctcctgg     3840

catgttattg ataacagagc caggaagtcc agtgtacatt acagattttc tgggagaaat     3900

agtccttcca gagaaaggat tccttcccag cctccaggct ggtgtctcat gaggtgagga     3960

ggctggccca gaaggaaggg gacgttaggt ggtgaagcag gctcccctgg gcctctgagg     4020

gccagcagtc ccaaccattt gcctcttcgt tttgaccaag cacaaaagag atattcccta     4080

gaagtgtcac acggaggctt ctgtgccaaa gactgccttg tagaggtctc atcacctcac     4140

acttcttgac ttcacaaaat tgtggccctg agatcagtac tcctctctta agtatttatt     4200

attattatta tttactttac ctcaagcaga cagacatagg ttttgaggct tgaatacatg     4260

gcagtggaat acaaggccct ccctagcagc cgccccaggc ctggaaagtg ggagatttca     4320

ttcgcccggg ttaaaaatcc agaggaagac agaagagagg agtcctagga actgagcaga     4380

ttttagagac gcaaatgatg tttaagagag ccttgtgatt tgtagcaagc atgggcactg     4440

ctttttctta ctaatgtggt agatctacac gaacattcta ggctgttctg ctcagagcga     4500

ggaaccactg ctcctcaatg gggagggaac ataccaccca gccaggctta gcattgggtt     4560

ttatccttta ataaaagttt tataatgaat cctgttcacc ttaaagtgtg attatggaga     4620

tgattggctc catattccac cacgtcattc cttcaactca ccagacacct ttctttagtt     4680

gaaataaacc agcatgacct ggagatcatg gtgactgtaa gctaagtctg ttttcatgcc     4740

agatttcagc cccacccaga gtgtgctcta gatgttgttg atttgaatgg ttttcccagt     4800

tcccactcca catggggaag ttgaatgaat gcacacctgc tgctcacttc ttgtgaggct     4860

gccttttgtg atcaaataac aggaagttct gctttagagg agggcacgat gaccatgtgg     4920

cagtctgcaa gtggaatttt gggatggcag cccgaggaac atccagagtt actgtgtgac     4980

ttggtcctgc catcgttagc tttgaaatca caggcattgg gctctgtttt gacaccattc     5040

attggactgc gggacagtca ttctttacgt tctctcttga gctggtgaga gaggaggaag     5100

agggaagtca agagcaacct ccaaggccta tgtcagcctc ttctccttgg gtcttggggt     5160

gggttagaac tgggttccag tctggccaga tgggttgctg gctgcactga gggtgattct     5220

tctcagaaga tgggctgcct gtggtcagga cagggcatac cagtctggac tccaccttcc     5280

cagacaccta ctttaaggac ctgtggaaac tgggtgatcc aattataggg ctggggcaac     5340

cctgctttgg ccaccctcat ttacaaactt aggttgggag cttgggtttc ctgtctcact     5400

tccaaaagcc ttcaagatgg cagcagatgg acacaccctc tcatttcttg tgtcttgtct     5460

gtcagatggc aggaggcctg tatcagtaaa tttgaggaaa atgttctctc ctgggccagc     5520

ctcacagctt gcgttgggtg tgttggaatt gttctcttcg gccttgttct gccttgtgat     5580

cttttcaatt cagtgaataa accaggaatc cattttttca ccaacccacc ctgtagattg     5640

tcagcttttt gtttgagaga tgcctggtct cacagttaca tgtatcagag tgtgtgtaag     5700

ttgtctgtgt tagaaaggtt ggggtggggg ctttgttgca ggggattaga ctgttctttc     5760

ttcatcataa tttgagatac atcctgagta tgactgtcta accctttctg tgtggcagaa     5820

aaatatgttt tccaggtagt ttttactact acagagagtc tgtaaataag tgctttaaaa     5880

aaataacaaa ccaataagat atttgtctcc tatataaaca ttctgtgtat ttagcacttg     5940

aaaatcaaca aatccagaat ttaaaaaaat gccacagact tttcaaagcc caactctact     6000

tttttgagaa tttgtccgta cctactaata tgccttattc ttcttcacct agtgttttaa     6060

aagtcctggg tagaaagagt tttagaaatg taatcagttg ttcagcttca ataatataga     6120

gatctaacat agtcagtcct caggccccct aaagaaacaa gcaagaaagt gagggccatc     6180

actagggttg gctttgggga ggggaaaact aaggactgct tttgccaaat gatatttttg     6240

ataatgtaag gaaacacagg gaccacaaaa cctttttttt ttttttaagt gtgaaagatt     6300

agtgcctttt ggcatacttt tgattttaga ggatatagta tcggcattga caaatcacgt     6360

agaaacaaag aatgctatag atgacaacag tattaaatgt tactcctgat tctgcagaac     6420

agcttttgaa gatactgggg ggtatcttca agcctcagag cagcttgttt cagatagaaa     6480

ttctctatgg gttgaaatgc caaaaacaga aaacatgatg ttgactcatg taatttagtc     6540

cattttagca gagcctttag tgttaacacc agtggcgagg agcattgcat attctctgtc     6600

agcagcagca ctcccacacc aggtggttct gggctctctg taggctggtc ctagtaggtg     6660

acacccagca acacccctgt tggacaggat tgattgttcg cagtcttaga ccaacacttc     6720

agtcagaaat gttactggga ggaggaaagg aaaatcactt tttttcctcc atgtggaaat     6780

gaggagagag gaaagtggat tgcaaaccaa aatgtgagtc agtgtgatga agcagtggct     6840

ctgtcatctc ggcctttatc caataacaaa ccagcatctc ttaaaggcgc ttttggccta     6900

gacacccctg aagtttggat gaagtctggt ggattccctg tctgttgtat ttctgtgtgc     6960

ctgttccctt cattgctgtg agttgggagt gcattgagag atgatgtcca tctgatatat     7020

tcctgtgaaa taaactgcca gcaaactttc taacttgtat tttaactgtt aaagaagaga     7080

ttaaaaactt cggctttgga catgtccaca ttatggactg tcatcttatt tttaaaagtc     7140

attctttacg tttaaaattt taaaataaaa accttctgag gtattgatgt agtccaccgt     7200

gtaaatgtta ccttctctcc atgctgccat tatgccaaaa caaaagctgt gataaaaaaa     7260

gtgcttgaga gagtgtgttg ataagaaagt gatttattta cagatggaag tctttgtttc     7320

atgaagctac caaactttaa aaagaatgtc accctttttt ttgtttgtta tggaaaccag     7380

agattgtaaa atggaaaaag aatcgttttt ttgttgactt tttgatgctg gcacgaggtt     7440

tttgtccact tttttcatat atctgtgtat aaaaaaattg ttgtttacta tggaattagt     7500

attacatttt gaggtaaaca aaagaatttg tattgcttga taaatattag cttgtaaatt     7560

taaagtttct ttacttcaat taacttaaag gaccaataaa cccataaaag atgctttctt     7620

ta                                                                    7622


<210> 1901
<211> 1388
<212> DNA
<213> Homo sapiens

<400> 1901
tggcctgact cacaggacac taaggctcct tttctgaaga agccttttac cagtctcatt       60

taggggatgg gaacaacatg tcttcaccta gggactttag agcagagcct gtaaacgatt      120

atgagggaaa tgactctgaa gcagaagact tgaatttcag ggagactttg ccttcatcaa      180

gtcaggaaaa cacacctaga tcaaaggttt ttgaaaataa agttaattca gagaaggtaa      240

aactttctct tcggaatttc ccacataatg attatgagga tgtttttgaa gagccttcag      300

aaagtggcag tgatcccagc atgtggacag ccagaggccc cttcagaaga gacaggtgga      360

gcagtgagga tgaggaggct gcagggccat cacaggctct ctcccctcta ctttctgata      420

cgcgcaaaat tgtttctgaa ggagaactag atcagttggc tcagattcgg ccattaatat      480

tcaattttca tgagcagaca gccatcaagg attgtttgaa aatccttgag gaaaaaacag      540

cagcgtatga tatcatgcag gaatttatgg ctttagaact taagaatctg cctggtgagt      600

tcaactctgg gaatcaacca agcaacagag aaaaaaatag ataccgagat attcttccat      660

atgattcaac acgcgttcct cttggaaaaa gcaaggacta catcaatgct agttatatta      720

gaatagtcaa ttgtggagaa gagtattttt atatcgctac tcaaggacca ctgctgagca      780

ccatagatga cttttggcaa atggtgttgg aaaataattc aaatgttatt gccatgataa      840

ccagagagat agaaggtgga attatcaaat gctaccatta ctggcccatt tctctgaaga      900

agccattgga attgaaacac ttccgtgtat tcctggagaa ctaccagata cttcaatatt      960

tcatcattcg aatgtttcaa gttgtggaga agtccacggg aactagtcac tctgtaaaac     1020

agttgcagtt caccaagtgg ccagaccatg gcactcctgc ctcagcagat agcttcataa     1080

aatatattcg ttatgcaagg aagagccacc ttacaggacc catggttgtt cactgcagtg     1140

ccggcatagg ccggacaggg gtgttcctat gtgtggatgt cgtgttctgt gccatcgtaa     1200

agaactgttc attcaacatc atggatatag tggcccaaat gagagaacaa cgttctggca     1260

tggttcaaac gaaggagcag tatcactttt gttacgatat tgtgcttgaa gttcttcgga     1320

aacttctgac tttggattaa gaaagacttc tgttgcctct cacttgaaat taccaagtgg     1380

gtttgcac                                                              1388


<210> 1902
<211> 2539
<212> DNA
<213> Homo sapiens

<400> 1902
gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc ctgactcaca       60

ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg ggatgggaac      120

aacatgtctt cacctaggga ctttagagca gagcctgtaa acgattatga gggaaatgac      180

tctgaagcag aagacttgaa tttcagggag actttgcctt catcaagtca ggaaaacaca      240

cctagatcaa aggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg      300

aatttcccac ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat      360

cccagcatgt ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag      420

gaggctgcag ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt      480

tctgaaggag aactagatca gttggctcag attcggccat taatattcaa ttttcatgag      540

cagacagcca tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc      600

atgcaggaat ttatgacggg aactagtcac tctgtaaaac agttgcagtt caccaagtgg      660

ccagaccatg gcactcctgc ctcagcagat agcttcataa aatatattcg ttatgcaagg      720

aagagccacc ttacaggacc catggttgtt cactgcagtg ccggcatagg ccggacaggg      780

gtgttcctat gtgtggatgt cgtgttctgt gccatcgtaa agaactgttc attcaacatc      840

atggatatag tggcccaaat gagagaacaa cgttctggca tggttcaaac gaaggagcag      900

tatcactttt gttacgatat tgtgcttgaa gttcttcgga aacttctgac tttggattaa      960

gaaagacttc tgttgcctct cacttgaaat taccaagtgg gtttgcacct cctcataaag     1020

aacatgtttg cactgtgctg aagggctttg ctatgcatac aatctgcttt cttggtttat     1080

cagtttattt tctttctaaa agctccctga agggcaatat catttggctt ggggtgatca     1140

gtgtttactt attgatcttg ctagacaata tcaaaataac ttcccacatt ttccagtgaa     1200

acagatgtta cataaaacga ttgcagcttg gctatttggt tgaagggatt acagagccca     1260

ataaaggatt taaaatatat tcattaagat tttatttgga aaggtggctg gagagagctg     1320

aggatttcca ggactttgta agttcttatt ctgggagaac ataaggccaa taatcatgac     1380

ctcttccagg catttttaag acagatgtct attcatgttc tttagctaga gcctgtactt     1440

tttgctggca tttgaataac ccagtttaaa aagagtccag ttagggtgga ctaactttgg     1500

acacaaattg gcttccattt cctacatttt catactgctg ccttcctaca gctgctagac     1560

caagacctgt tggtctggga agcatttcat ggatagggag agctcctctc ggtgaacagt     1620

ccaaaactaa aatagatgtt tatatagaaa gcccaagagg agacttttgc catgcctgag     1680

ttctttccta tcccacccta acacttaaca tattacttag tctgctttgt taaaagcaag     1740

tattaccttt aacttgcctc ttactctttg ccctttagct aactaataaa gtttgatata     1800

ggcattatta tataattctg agtcattcat ggtatctctc atgtttgatg tatttttcaa     1860

actaagatct atgatagttt tttttccaga gttccattaa atcatttatt tcctttactt     1920

tctcacctct gttgaaacat ttagaaactg gatttgggaa cccaattttg gaaaaccaga     1980

ttcatagtca tgaaaatgga aacttccata ttctgttttt gaaaagatgt ggccattatt     2040

acagtaattt tattatagga ctttgcctcg tacaattaat agtgatattt tggacaagga     2100

gttctggtga caagctatac ctaattataa gctataaaac aatagatatg agtgtttgta     2160

cagtttaact caatggagat cagaatattc tatgtattga gaaaatgttt aatatcaatc     2220

tataaatctt gaatttctaa gaggcttatt ttgttctttt ggctgaatga gtatatttga     2280

attggttgaa taattaataa ttctcattgt aaaaataatt atatgccaaa aatatatttg     2340

atgttaaatc aaatagatga ttctgtttac attgttcata tgaataataa tctgtgttaa     2400

tttcattttg ataattggcc tttaatattt gtatctctaa ttttattttc tctctgttac     2460

tgtaaaataa tagctataat gtataacaat tttcttcaga agaattctat gctattatta     2520

aaataaaata tttactgtg                                                  2539


<210> 1903
<211> 2481
<212> DNA
<213> Homo sapiens

<400> 1903
gcgtggaccc aactggcgag gctgctgggg ttgcagcggg acagttgggg cggccccgca       60

ggcccaggtg aacaaaaatt gtttgctggc ccccaggata ctaactagac ctttggcctg      120

actcacagga cactaaggct ccttttctga agaagccttt taccagtctc atttagggga      180

tgggaacaac atgtcttcac ctagggactt tagagcagag cctgtaaacg attatgaggg      240

aaatgactct gaagcagaag acttgaattt cagggagact ttgccttcat caagtcagga      300

aaacacacct agatcaaagg tttttgaaaa taaagttaat tcagagaagg taaaactttc      360

tcttcggaat ttcccacata atgattatga ggatgttttt gaagagcctt cagaaagtgg      420

cagtgatccc agcatgtgga cagccagagg ccccttcaga agagacaggt ggagcagtga      480

ggatgaggag gctgcagggc catcacaggc tctctcccct ctactttctg atacgcgcaa      540

aattgtttct gaaggagaac tagatcagtt ggctcagatt cggccattaa tattcaattt      600

tcatgagcag acagccatca aggattgttt gaaaatcctt gaggaaaaaa cagcagcgta      660

tgatatcatg caggaattta tggctttaga acttaagaat ctgcctggtg agttcaactc      720

tgggaatcaa ccaagcaaca gagaaaaaaa tagataccga gatattcttc catttcaaca      780

tcatggatat agtggcccaa atgagagaac aacgttctgg catggttcaa acgaaggagc      840

agtatcactt ttgttacgat attgtgcttg aagttcttcg gaaacttctg actttggatt      900

aagaaagact tctgttgcct ctcacttgaa attaccaagt gggtttgcac ctcctcataa      960

agaacatgtt tgcactgtgc tgaagggctt tgctatgcat acaatctgct ttcttggttt     1020

atcagtttat tttctttcta aaagctccct gaagggcaat atcatttggc ttggggtgat     1080

cagtgtttac ttattgatct tgctagacaa tatcaaaata acttcccaca ttttccagtg     1140

aaacagatgt tacataaaac gattgcagct tggctatttg gttgaaggga ttacagagcc     1200

caataaagga tttaaaatat attcattaag attttatttg gaaaggtggc tggagagagc     1260

tgaggatttc caggactttg taagttctta ttctgggaga acataaggcc aataatcatg     1320

acctcttcca ggcattttta agacagatgt ctattcatgt tctttagcta gagcctgtac     1380

tttttgctgg catttgaata acccagttta aaaagagtcc agttagggtg gactaacttt     1440

ggacacaaat tggcttccat ttcctacatt ttcatactgc tgccttccta cagctgctag     1500

accaagacct gttggtctgg gaagcatttc atggataggg agagctcctc tcggtgaaca     1560

gtccaaaact aaaatagatg tttatataga aagcccaaga ggagactttt gccatgcctg     1620

agttctttcc tatcccaccc taacacttaa catattactt agtctgcttt gttaaaagca     1680

agtattacct ttaacttgcc tcttactctt tgccctttag ctaactaata aagtttgata     1740

taggcattat tatataattc tgagtcattc atggtatctc tcatgtttga tgtatttttc     1800

aaactaagat ctatgatagt tttttttcca gagttccatt aaatcattta tttcctttac     1860

tttctcacct ctgttgaaac atttagaaac tggatttggg aacccaattt tggaaaacca     1920

gattcatagt catgaaaatg gaaacttcca tattctgttt ttgaaaagat gtggccatta     1980

ttacagtaat tttattatag gactttgcct cgtacaatta atagtgatat tttggacaag     2040

gagttctggt gacaagctat acctaattat aagctataaa acaatagata tgagtgtttg     2100

tacagtttaa ctcaatggag atcagaatat tctatgtatt gagaaaatgt ttaatatcaa     2160

tctataaatc ttgaatttct aagaggctta ttttgttctt ttggctgaat gagtatattt     2220

gaattggttg aataattaat aattctcatt gtaaaaataa ttatatgcca aaaatatatt     2280

tgatgttaaa tcaaatagat gattctgttt acattgttca tatgaataat aatctgtgtt     2340

aatttcattt tgataattgg cctttaatat ttgtatctct aattttattt tctctctgtt     2400

actgtaaaat aatagctata atgtataaca attttcttca gaagaattct atgctattat     2460

taaaataaaa tatttactgt g                                               2481


<210> 1904
<211> 1653
<212> DNA
<213> Homo sapiens

<400> 1904
cctggaccag ggggacatct gagaagcatg atgttgagtg ccagacagct aggtctccaa       60

agttgggctc gttgctggag tctgccccct caaccgctga attcttgctg ggagtagtag      120

cagtttggga atgccatctg cagcatggag ctggggttga gcttggacca ccccaagacc      180

tggggtggat cttaagggtc agcttgagcc taggctctcg agtcctgaca tcatcctcta      240

ccgccacgct ttccagctgt cagccttggt ctccatctgg ttccttgagg gtgtggcctc      300

tgcgtcctgc tatcaccctt ccttgtctaa accttcccac ctgagtggag aggaacttgg      360

gggaaaatct ctaagcatgg gctcttcctg ctgtcctatg cttcctatcc cctagggtta      420

gtggtgcgtg ttgggtggtg gagcgaggga tcccttggag caaggttctt agagaacttt      480

gggtctgaaa gcagctcaaa ccttccaaag ccccaagctt ccctgtgcta ttagagcacc      540

tcctcctgga gagagcggct ctcgtggctg gggagttgga tgcaccaaac ctgtgtgcgg      600

ctggagaggg aggcttctgc cagaccctct cccgggcctg tcctgccacc caggcccctc      660

cccagtcaca ctgagctcca gatcagggaa gggccgaaaa ggacgatcag ggcagccgca      720

gaaggggcgc cctgcgtggg acgggtccgt tgcgcgcctg gtaaccgagg gggaagggaa      780

ggggcctctg gcgtgcgggg cggtgtcgcg caggtcccac cccgcctgcc cgcgccgccc      840

attggtcccg agcgcgatga cttggcgggc ggagcaggaa ggaaaccgct cccgagcacg      900

gcggcggcgt cgtctcccgg cagtgcagct gccgctaccg ccgccctctg cccgccggcc      960

cgtctgtcta cccccagcat gagcggcctg cgcgtctaca gcacgtcggt caccggctcc     1020

cgcgaaatca agtcccagca gagcgaggtg acccgaatcc tggatgggaa gcgcatccaa     1080

taccagctag tggacatctc ccaggacaac gccctgaggg atgagatgcg agccttggca     1140

ggcaacccca aggccacccc accccagatt gtcaacgggg accagtactg tggggactat     1200

gagctcttcg tggaggctgt ggaacaaaac acgctgcagg agttcctgaa gctggcttga     1260

gtcaagcctg tccagagttc ccctgctgga ctccatcacc acactccccc cagccttcac     1320

ctggccatga aggacctttt gaccaactcc ctgtcattcc taacctaacc ttagagtccc     1380

tcccccaatg caggccactt ctcctccctc ctctctaaat gtagtcccct ctcctccatc     1440

taaaggcaac attccttacc cattagtctc agaaattgtc ttaagcaaca gccccaaatg     1500

ctggctgccc ccagccaagc attggggccg ccatcctgcc tggcactggc tgatgggcac     1560

ctctgttggt tccatcagcc agagctctgc caaaggcccc gcagtccctc tcccaggagg     1620

accctagagg caattaaatg atgtcctgtt cca                                  1653


<210> 1905
<211> 3301
<212> DNA
<213> Homo sapiens

<400> 1905
caatatatga ggggatacag tgcctcaggt ttaaaagagc aggaagctga gtgagaggtt       60

gcagaaaaag tgtcttcgct cggcagaggt tacaggtggc atctcagaaa gagctttgag      120

gctacaggct gtagtcggga aggggatcgg agaactgtgt gaagggacag cttagggact      180

agcgtcctgg gactaggggg aagttcgcga ctttctgaag actggcagga atgtgcctcc      240

tggccctcga tgcttccccc ctgaggggag gcatcgtgag ggactgtggc aggcttcact      300

gaacgctgag ccggggaggt ccaactccac gtatggatcc ggggaatgag aattcagcca      360

cagaggctgc cgcgatcata gacctagatc ccgacttcga accccagagc cgtccccgct      420

cctgcacctg gccccttccc cgaccagaga tcgctaacca gccgtccgag ccgcccgagg      480

tggagccaga tctgggggaa aaggtacaca cggaggggcg ctcagagccg atcctgttgc      540

cctctcggct cccagagccg gccgggggcc cccagcccgg aatcctgggg gctgtaacag      600

gtcctcggaa gggaggctcc cgccggaatg cctggggaaa tcagtcatat gcagaactca      660

tcagccaggc cattgaaagc gccccggaga agcgactgac acttgcccag atctacgagt      720

ggatggtccg tactgtaccc tacttcaagg acaagggtga cagcaacagc tcagcaggat      780

ggaagaactc gatccgccac aacctgtccc tgcacagcaa gttcatcaag gttcacaacg      840

aggccaccgg caaaagctct tggtggatgc tgaaccctga gggaggcaag agcggcaaag      900

ccccccgccg ccgggccgcc tccatggata gcagcagcaa gctgctccgg ggccgcagta      960

aagcccccaa gaagaaacca tctgtgctgc cagctccacc cgaaggtgcc actccaacga     1020

gccctgtcgg ccactttgcc aagtggtcag gcagcccttg ctctcgaaac cgtgaagaag     1080

ccgatatgtg gaccaccttc cgtccacgaa gcagttcaaa tgccagcagt gtcagcaccc     1140

ggctgtcccc cttgaggcca gagtctgagg tgctggcgga ggaaatacca gcttcagtca     1200

gcagttatgc agggggtgtc cctcccaccc tcaatgaagg tctagagctg ttagatgggc     1260

tcaatctcac ctcttcccat tccctgctat ctcggagtgg tctctctggc ttctctttgc     1320

agcatcctgg ggttaccggc cccttacaca cctacagcag ctcccttttc agcccagcag     1380

aggggcccct gtcagcagga gaagggtgct tctccagctc ccaggctctg gaggccctgc     1440

tcacctctga tacgccacca ccccctgctg acgtcctcat gacccaggta gatcccattc     1500

tgtcccaggc tccgactctt ctgttgctgg gggggcttcc ttcctccagt aagctggcca     1560

cgggcgtcgg cctgtgtccc aagcccctag aggctccagg ccccagcagt ctggttccca     1620

ccctttctat gatagcacca cctccagtca tggcaagtgc ccccatcccc aaggctctgg     1680

ggactcctgt gctcacaccc cctactgaag ctgcaagcca agacagaatg cctcaggatc     1740

tagatcttga tatgtatatg gagaacctgg agtgtgacat ggataacatc atcagtgacc     1800

tcatggatga gggcgaggga ctggacttca actttgagcc agatccctga gtcatgcctg     1860

gaagctttgt cccctgcttc agatgtggag ccaggcgtgt tcatatctac tctttaccct     1920

tgagccctcc ccaggaattt gggaccctgc tttagagcta gggtggggtc tggtcacaca     1980

caggtgttga agaaattata aagataaagc tgccccatct ggggacgata tggggaggga     2040

gatgggaggg gaaaggggag agggtttttc tcactgtgcc aattaggggg taaggccccc     2100

tctcaggagc catcatcggc tttccccatt cctacccact taggctttgt agcaagatga     2160

gcaatgctgt tggaaatgtg aagtcaccag tggccttacc cctgcctttg ggagcaggat     2220

ttttttgtag agagtcttat ctgagctgag ccaggctagc tggagcctgg gatttctatg     2280

cagtggcccc ttaggccagt gatgtgcggt gggtgggctg tttaggggat ctggaagggc     2340

caaggtctga gcactggagt ggctcgccag gccaaatcac ccttagaagg ctgcagataa     2400

cagaaaggct ttttataaac ttttaaagaa atataaacac aaatatagag attttttaac     2460

catggcaggg tgctagtggt gggcagaatg cttttttttc tttctgaagg ctttgtgata     2520

gtgacatgat acaaacacta cagacaataa atattaggag acacagggaa gtggggagag     2580

gtggggagta atagtaaaca cagggaagag ctcccctacg gaccaggtat agagaaaggt     2640

ctatgcagaa ataggttaga gtttccctaa caaaaaagct aacccaggtc ccctcattcc     2700

ttcaacttgt gcctgggagt gtgtggtgtt agggtgcagc cacactcttc tatgacccag     2760

catgggttag tgctatggtg ggagagtaca ttgaaggcct ggaattagct tggggccagg     2820

gaagggactg ggaggggaga gaagagaagg agggaaggat ttaggatggt aaagttaggt     2880

acagagacct ccctgttcaa ggcccctgac agctgtccct gcccttcttc cccttccctg     2940

actgcagggg ttatgtggaa gtgtgtgtgg cagcaggcag cggggagggg aggaacaggg     3000

aagggggagc tggggagctt ggctgagggt ctgggaaatg agcagggatg gggggggatg     3060

tggatcaggt ttactagcac ctgccaggga ggccatctgg ggctccttct ccaccccagc     3120

ccccaaagca gcccttcccc cagtgccctt tgcatcgtcc cctcccccac ccctgctgtg     3180

ggttcccatc atttcctgtg tcagcgcctg gcctacccag attgtatcat gtgctagatt     3240

ggagtgggga agtgtgtcaa atcaataaat gaataaattc aataaatgcc tataaccagc     3300

t                                                                     3301


<210> 1906
<211> 1770
<212> DNA
<213> Homo sapiens

<400> 1906
gacagaattc gggcaccagg agaaggaagc caacaggatc cgacccggtg ttttgtgaca       60

aaggcaagac ccccaggtct acttagagca aagttagtag aggaggcagc taggcgtggc      120

tctcattcct tcccacagaa tggattataa gtcgagcctg atccaggatg ggaatcccat      180

ggagaacttg gagaagcagc tgatctgccc tatctgcctg gagatgttta ccaagccagt      240

ggtcatcttg ccgtgccagc acaacctgtg ccggaagtgt gccaatgaca tcttccaggc      300

tgcaaatccc tactggacca gccggggcag ctcagtgtcc atgtctggag gccgtttccg      360

ctgccccacc tgccgccacg aggtgatcat ggatcgtcac ggagtgtacg gcctgcagag      420

gaacctgctg gtggagaaca tcatcgacat ctacaaacag gagtgctcca gtcggccgct      480

gcagaagggc agtcacccca tgtgcaagga gcacgaagat gagaaaatca acatctactg      540

tctcacgtgt gaggtgccca cctgctccat gtgcaaggtg tttgggatcc acaaggcctg      600

cgaggtggcc ccattgcaga gtgtcttcca gggacaaaag actgaactga ataactgtat      660

ctccatgctg gtggcgggga atgaccgtgt gcagaccatc atcactcagc tggaggattc      720

ccgtcgagtg accaaggaga acagtcacca ggtaaaggaa gagctgagcc agaagtttga      780

cacgttgtat gccatcctgg atgagaagaa aagtgagttg ctgcagcgga tcacgcagga      840

gcaggagaaa aagcttagct tcatcgaggc cctcatccag cagtaccagg agcagctgga      900

caagtccaca aagctggtgg aaactgccat ccagtccctg gacgagcctg ggggagccac      960

cttcctcttg actgccaagc aactcatcaa aagcattgtg gaagcttcca agggctgcca     1020

gctggggaag acagagcagg gctttgagaa catggacttc tttactttgg atttagagca     1080

catagcagac gccctgagag ccattgactt tgggacagat gaggaagagg aagaattcat     1140

tgaagaagaa gatcaggaag aggaagagtc cacagaaggg aaggaagaag gacaccagta     1200

aggagctgga tgaatgagag gcccccagat gcagagagac tggagagggt ggggaggggc     1260

ccagcggcct tggtgacagg cccagggtgg gaggggtcgg ggcccctgga ggggcaatgg     1320

ggaggtgatg tcttctctct gctcagagag cagggactag ggtaggaccc tcaccgctgc     1380

gtccagcaga cactgaacca gaattggaaa cgtgcttgaa acaatcacac aggacacttt     1440

tctacattgg tgcaaaatgg aatattttgt acatttttaa aatgtgattt ttgtatatac     1500

ttgtatatgt atgccaattt ggtgcttttt gtaaaggaac ttttgtataa taatgcctgg     1560

tcgttgggtg acctgcgatt gtcagaaaga ggggaaggaa gccaggttga tacagctgcc     1620

cacttccttt cctgagcagg aggatggggt agcactcaca gggacgatgt gctgtatttc     1680

agtgcctatc ccagacatac ggggtggtaa ctgagtttgt gttatatgtt gttttaataa     1740

atgcacaatg ctctcttcct gttcttcaaa                                      1770


<210> 1907
<211> 3581
<212> DNA
<213> Homo sapiens

<400> 1907
cgagaagtgc ttccaagcgt ccattttgag ccttggaaac tacgacgacc aaagggccac       60

gggttcatgg gtcgtttctc atttccgtcg agttaaacgt ctggggctgc ttctgaggaa      120

tcagcttgac tggccagcaa gttcagctcc ggcaagtcat ttgattcacc cggtgatgaa      180

atgggggtca accagtctgt gggctttcca cctgtcacag gaccccacct cgtaggctgt      240

ggggatgtga tggagggtca gaatctccag gggagcttct ttcgactctt ctacccctgc      300

caaaaggcag aggagaccat ggagcagccc ctgtggattc cccgctatga gtactgcact      360

ggcctggccg agtacctgca gtttaataag cgctgcgggg gcttgctgtt caacctggcg      420

gtgggatctt gtcgcctgcc tgttagctgg aatggcccct ttaagacaaa ggactctgga      480

taccccttga tcatcttctc ccatggccta ggagccttca ggactttgta ttcagccttc      540

tgcatggagc tggcctcacg tggctttgtg gttgctgtgc cagagcacag ggaccggtca      600

gcggcaacca cctatttctg caagcaggcc ccagaagaga accagcccac caatgaatcg      660

ctgcaggagg aatggatccc tttccgtcga gttgaggaag gggagaagga atttcatgtt      720

cggaatcccc aggtgcatca gcgggtaagc gagtgtttac gggtgttgaa gatcctgcaa      780

gaggtcactg ctgggcagac tgtcttcaac atcttgcctg gtggcttgga tctgatgact      840

ttgaagggca acattgacat gagccgtgtg gctgtgatgg gacattcatt tggaggggcc      900

acagctattc tggctttggc caaggagacc caatttcggt gtgcggtggc tctggatgct      960

tggatgtttc ctctggaacg tgacttttac cccaaggccc gaggacctgt gttctttatc     1020

aatactgaga aattccagac aatggagagt gtcaatttga tgaagaagat atgtgcccag     1080

catgaacagt ctaggatcat aaccgttctt ggttctgttc atcggagtca aactgacttt     1140

gcttttgtga ctggcaactt gattggtaaa ttcttctcca ctgaaacccg tgggagcctg     1200

gacccctatg aagggcagga ggttatggta cgggccatgt tggccttcct gcagaagcac     1260

ctcgacctga aagaagacta taatcaatgg aacaacctta ttgaaggcat tggaccgtcg     1320

ctcaccccag gggcccccca ccatctgtcc agcctgtagg cacaactggc catttgtaaa     1380

gtcacttcag ccaagttttc atttgggagc tacccaaggg cacccatgag ctcctatcaa     1440

gaagtgatca acgtgacccc ttttcacaga ttgaaaggtg taatcacact gctgcttgga     1500

taactgggta ctttgatctt agatttgatc ttaaaatcac tttgggactg ggatcccttg     1560

ctgattgaca aacagacttt ctgggacctt gatggagtgg ggaacaagca gtagagtggg     1620

actgggggag acccaggccc cgggctgagc actgtgaggc ctggatgtga agactcagcc     1680

cagcgaagct cattccctta cccccggcca gtgctgctgc ttcagtggaa gagatgaagc     1740

caaaggacag aatgaaaatc cctaccttca gagactctag cccagcccaa caccatctct     1800

tcctacctct cagccttctc cctccccagg gccacttgtt gaagtctgag cactttatgt     1860

aaatttctag gtgtgagccg tgatcacatt ttctatttat ttccaagtct tctcattgta     1920

tggaacatag tactacttat acttacagta gtaagttata cttgtgagcc cacagagtgg     1980

cagacagcat ggctctcaca gcacagggag aaaaactgag gtacacagag gtacctcaga     2040

agctctggat gtctttgggg gttttgctaa gtgtatcttg ataggaaaca acaaaagcag     2100

gttgagatgg ggaagatgac agaacaacag tgttaaatgg ccatttgcac aggcctttgc     2160

cacaacagag aagtagtttg gtcagctaaa actcagctgc agcctggaca gtagagcgag     2220

accccatctt aaaaataaag aaggctgggc gtggtggctc atgcctgtaa tcccaacact     2280

ttgggaggcc aaggcaggca gatcacttaa ggccaggagt tcaagaccac ctggccaaca     2340

tggtgaaacc ccgtctctac taaaaataca aaaaattagc ctggcgtaat ggcaggcgcc     2400

tataatccca gctactcagg aggctgaagc agaagaatca cttgaaccta ggaggcggag     2460

gttgcagtga gtcaagatcg cgccactgca ctccagcctg ggtgacagag caagactctg     2520

tcttaaaaaa aaaaaaaaga aaaagaaaaa tttaaaataa ataaaattta aaaacgcaga     2580

aggccactcc cagagaggcc taggagtacc ttggtcattt tttcttgcct caaatattat     2640

aaacctccaa cttgctcaga atcagggtgc ttttattgtc tgttttctgg ctctgaggcc     2700

cttgccccaa atttaagtca gatacagact gaatttccat tctgttctgt ttataatatg     2760

aatgatatta atactcttgt ttgcttaatg ttatgttgga attttctgtt taatctgcag     2820

tagagcaaga tggagagcca tctggaattg acttccttct gtctttcttc tgtgttcgct     2880

tactacttgg gcccatgtgg gaaaaaaact ttaaaaggaa ggaagtcttc ttagggatcc     2940

agttcaaagc tatttggggg catcaaactg aaactctctt ctccactact caagacttcg     3000

tgcctcagtc caagtaggta agagcaaaag ggaaatgcat ctctacacaa tggcccatgg     3060

tcagggccac cagagcaagc tgggcctaga tctccacctg tcagtgactg gccattctaa     3120

gaggtgaaac agcagatcgt tgaggctgtg agggaggatc tttgaattcc catgagacat     3180

agcataagaa gggtatcatt aaagccctgg gctctaaagt tacagagcct ggttttgagt     3240

cctggctcca ccactgccaa ctgggtaaat ttgagcaaat ggtattctct ttcttatctc     3300

agctcctgcg tttctaaaat gagggtctgc gttatgaata gttaggagga ttaagtgaga     3360

ggatgtataa cccatgggtt acttaaaagt atatttccta ccttccaaac atgagatttt     3420

tctagttata gtttcttttc tagcttgatt gctttgtggt cagagaaaat gacccatatg     3480

gtttccatcc ttcaaaattt gttgaaactt ggttgttggc ctagtatgag atcaatgttg     3540

taaatgtgcc atgtatgttt aaaaagacta tatattctga a                         3581


<210> 1908
<211> 2523
<212> DNA
<213> Homo sapiens

<400> 1908
tgaggaatca gcttgactgg caacaggaag ccgagaggaa accagcaagc ggctgctgtt       60

ctgtgttccc ccatccagcc agcaagttca gctccggcaa gtcatttgat tcacccggtg      120

atgaaatggg ggtcaaccag tctgtgggct ttccacctgt cacaggaccc cacctcgtag      180

gctgtgggga tgtgatggag ggtcagaatc tccaggggag cttctttcga ctcttctacc      240

cctgccaaaa ggcagaggag accatggagc agcccctgtg gattccccgc tatgagtact      300

gcactggcct ggccgagtac ctgcagttta ataagcgctg cgggggcttg ctgttcaacc      360

tggcggtggg atcttgtcgc ctgcctgtta gctggaatgg cccctttaag acaaaggact      420

ctggataccc cttgatcatc ttctcccatg gcctaggagc cttcaggact ttgtattcag      480

ccttctgcat ggagctggcc tcacgtggct ttgtggttgc tgtgccagag cacagggacc      540

ggtcagcggc aaccacctat ttctgcaagc aggccccaga agagaaccag cccaccaatg      600

aatcgctgca ggaggaatgg atccctttcc gtcgagttga ggaaggggag aaggaatttc      660

atgttcggaa tccccaggtg catcagcggg taagcgagtg tttacgggtg ttgaagatcc      720

tgcaagaggt cactgctggg cagactgtct tcaacatctt gcctggtggc ttggatctga      780

tgactttgaa gggcaacatt gacatgagcc gtgtggctgt gatgggacat tcatttggag      840

gggccacagc tattctggct ttggccaagg agacccaatt tcggtgtgcg gtggctctgg      900

atgcttggat gtttcctctg gaacgtgact tttaccccaa ggcccgagga cctgtgttct      960

ttatcaatac tgagaaattc cagacaatgg agagtgtcaa tttgatgaag aagatatgtg     1020

cccagcatga acagtctagg atcataaccg ttcttggttc tgttcatcgg agtcaaactg     1080

actttgcttt tgtgactggc aacttgattg gtaaattctt ctccactgaa acccgtggga     1140

gcctggaccc ctatgaaggg caggaggtta tggtacgggc catgttggcc ttcctgcaga     1200

agcacctcga cctgaaagaa gactataatc aatggaacaa ccttattgaa ggcattggac     1260

cgtcgctcac cccaggggcc ccccaccatc tgtccagcct gtaggcacaa ctggccattt     1320

gtaaagtcac ttcagccaag ttttcatttg ggagctaccc aagggcaccc atgagctcct     1380

atcaagaagt gatcaacgtg accccttttc acagattgaa aggtgtaatc acactgctgc     1440

ttggataact gggtactttg atcttagatt tgatcttaaa atcactttgg gactgggatc     1500

ccttgctgat tgacaaacag actttctggg accttgatgg agtggggaac aagcagtaga     1560

gtgggactgg gggagaccca ggccccgggc tgagcactgt gaggcctgga tgtgaagact     1620

cagcccagcg aagctcattc ccttaccccc ggccagtgct gctgcttcag tggaagagat     1680

gaagccaaag gacagaatga aaatccctac cttcagagac tctagcccag cccaacacca     1740

tctcttccta cctctcagcc ttctccctcc ccagggccac ttgttgaagt ctgagcactt     1800

tatgtaaatt tctaggtgtg agccgtgatc acattttcta tttatttcca agtcttctca     1860

ttgtatggaa catagtacta cttatactta cagtagtaag ttatacttgt gagcccacag     1920

agtggcagac agcatggctc tcacagcaca gggagaaaaa ctgaggtaca cagaggtacc     1980

tcagaagctc tggatgtctt tgggggtttt gctaagtgta tcttgatagg aaacaacaaa     2040

agcaggttga gatggggaag atgacagaac aacagtgtta aatggccatt tgcacaggcc     2100

tttgccacaa cagagaagta gtttggtcag ctaaaactca gctgcagcct ggacagtaga     2160

gcgagacccc atcttaaaaa taaagaaggc tgggcgtggt ggctcatgcc tgtaatccca     2220

acactttggg aggccaaggc aggcagatca cttaaggcca ggagttcaag accacctggc     2280

caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagcctggc gtaatggcag     2340

gcgcctataa tcccagctac tcaggaggct gaagcagaag aatcacttga acctaggagg     2400

cggaggttgc agtgagtcaa gatcgcgcca ctgcactcca gcctgggtga cagagcaaga     2460

ctctgtctta aaaaaaaaaa aaagaaaaag aaaaatttaa aataaataaa atttaaaaac     2520

gca                                                                   2523


<210> 1909
<211> 847
<212> DNA
<213> Homo sapiens

<400> 1909
gttccttgga gagcttggag ccgcgcgccg gagggaatag gaaagcttgg ttacaacccg       60

ggacacccgg agcttcagga tggttcgtac taagacatgg accctgaaga agcactttgt      120

tggctatcct actaatagtg actttgagtt gaagacagct gagctcccac ccttaaaaaa      180

tggagaggtc ctgcttgaag ctttgttcct caccgtggat ccctacatga gagtggcagc      240

caaaagattg aaggaaggtg atacaatgat ggggcagcaa gtggccaagt aattatttcc      300

atttgtccca gtgcttggaa aatatgtctc ctctttacct cctgctgggt cctgtctctg      360

tccattgctc ctacaatttc ttcagcctat gttgttgact cactgtgtga tcttggaatc      420

aacttgggaa attctgtctc cttcctaact agctggaaag gagggaagga tgtgaaattg      480

tcattttttc agcttcactt tgccatcctt acttttaatt actaaaaaaa aaaaagtatt      540

tgtccaggtc atgatttatt gcgggatctg gccagcagcc cacaatgcaa cagggttctc      600

tctttgttcc caggtggatc ggcaggttga gaaataatag acacacacaa gatagtgaaa      660

gctgggtcca ggggcgtcac cgccttctgg ttccgtggtg ccaccaaagc actgaatata      720

cccgcattta ttattaagtt tagtgagggc gggggtaggt tagtgaggga tttagggtca      780

tttgattatg aggtgagatg gtcacatggg gatgaagtaa ttctttaaca tacatctgta      840

tgcagaa                                                                847


<210> 1910
<211> 1061
<212> DNA
<213> Homo sapiens

<400> 1910
gagatacgcg cacacacaca cacaaacgca ctcagatttc ccggaccctg gttttcctcc       60

tgtgaccctt tcggggccgg gctctcaccc taaagaagca gccccgccct ggggtggccc      120

caccctctct tgggacctgt cataagtcgg accccgggcg cccggctgcg cagtcccagc      180

cgccttcccc aggcagtgga accttcgggc tcctgagctt caggatggtt cgtactaaga      240

catggaccct gaagaagcac tttgttggct atcctactaa tagtgacttt gagttgaaga      300

cagctgagct cccaccctta aaaaatggag aggtcctgct tgaagctttg ttcctcaccg      360

tggatcccta catgagagtg gcagccaaaa gattgaagga aggtgataca atgatggggc      420

agcaagtggc caagtaatta tttccatttg tcccagtgct tggaaaatat gtctcctctt      480

tacctcctgc tgggtcctgt ctctgtccat tgctcctaca atttcttcag cctatgttgt      540

tgactcactg tgtgatcttg gaatcaactt gggaaattct gtctccttcc taactagctg      600

gaaaggaggg aaggatgtga aattgtcatt ttttcagctt cactttgcca tccttacttt      660

taattactaa aaaaaaaaaa gtatttgtcc aggtcatgat ttattgcggg atctggccag      720

cagcccacaa tgcaacaggg ttctctcttt gttcccaggt ggatcggcag gttgagaaat      780

aatagacaca cacaagatag tgaaagctgg gtccaggggc gtcaccgcct tctggttccg      840

tggtgccacc aaagcactga atatacccgc atttattatt aagtttagtg agggcggggg      900

taggttagtg agggatttag ggtcatttga ttatgaggtg agatggtcac atggggatga      960

agtaattctt taacatacat ctgtatgcag aagtacagta tacagagata agaatttaca     1020

atatagtgtg tgcatcagta atttctaaca gagccttaaa a                         1061


<210> 1911
<211> 2298
<212> DNA
<213> Homo sapiens

<400> 1911
gagcttcagg atggttcgta ctaagacatg gaccctgaag aagcactttg ttggctatcc       60

tactaatagt gactttgagt tgaagacagc tgagctccca cccttaaaaa atggagaggt      120

cctgcttgaa gctttgttcc tcaccgtgga tccctacatg agagtggcag ccaaaagatt      180

gaaggaaggt gatacaatga tggggcagca agtggccaac cagttattat aataccattg      240

gtagaaatcg tctatggatc tttactggaa tttcagtgac cttacagatt tatttagagg      300

aaactgacat ctttacaatt tctctctcca aacacaagag ttgtggaaag taaaaatgta      360

gccctaccaa aaggaactat tgtactggct tctccaggct ggacaacgca ctccatttct      420

gatgggaaag atctggaaaa gctgctgaca gagtggccag acacaatacc actgtctttg      480

gctctgggga cagttggcat gccaggcctg actgcctact ttggcctact tgaaatctgt      540

ggtgtgaagg gtggagaaac agtgatggtt aatgcagcag ctggagctgt gggctcagtc      600

gtggggcaga ttgcaaagct caagggctgc aaagttgttg gagcagtagg gtctgatgaa      660

aaggttgcct accttcaaaa gcttggattt gatgtcgtct ttaactacaa gacggtagag      720

tctttggaag aaaccttgaa gaaagcgtct cctgatggtt atgattgtta ttttgataat      780

gtaggtggag agttttcaaa cactgttatc ggccagatga agaaatttgg aaggattgcc      840

atatgtggag ccatctctac atataacaga accggcccac ttcccccagg cccaccccca      900

gagattgtta tctatcagga gcttcgcatg gaagcttttg tcgtctaccg ctggcaagga      960

gatgcccgcc aaaaagctct gaaggacttg ctgaaatggg tcttagagct tccctacttt     1020

gtaattgact gacttcaagc aaataatctt gtctataaat ccatgaagag tgctaagcca     1080

tcactggaat acattagcga aaaacttgta tcaggtaact caggtctcta tataagaccc     1140

cttaaaaaaa tctgaaaatg taaattagtt cccattagta ggctgtgcct tgtaggagaa     1200

agagaaatga agaccctttc tcactaacat gaacccttcc ttcccacact cccagataaa     1260

ggttaaacac atgttaaaag aaccttggct taaaggggag acagattatt agactgtcct     1320

gccatttata tttcctgaat aggacctgcc tcttcagggg ccagaggtaa tgaagggtgc     1380

tcttttctct gtctatttgt acctcctctg agatcattgt gttattaaac tttactatgc     1440

atcttattta gaaattgctt aatcgctctg ggcacggtgg ctcacgcctg taatcccagc     1500

actttgggag gccgaggcag gcagatcacg aggtcaggag atcgagacca tcctggctaa     1560

cacggtgaag ccctgtccct actaaaaata caaaacaatt agccgggcat ggtggtgagc     1620

acctgtagtc ccagctagtc gggaggctga ggcaggagaa tggcatgaac ctgggaggcg     1680

gagcttgcag tgagccaaga tcgcggcact gcactccagc ctgggcaaca gagcgagact     1740

ctgtctcaaa aaaaaaaaaa agaaagaaaa agagattgct taatcactgc cttatgacat     1800

ttcgcactat gatccgacac ctattatttc ttcttaggtg tactttgtaa tcttttttac     1860

atgtactgtg taagtggatc ttgccccacc ttgacttcaa gttcatggag gacaggactt     1920

ccatctctta ttttcaaggt ttccaatgat gtacctgata aatttgttgc taggatgaga     1980

acagtatatc attgagaata ttaaattaag ttttaaaatt tgttgttgct ttgatacagg     2040

gtaaaatcca gtacaaggaa tatatcattg aaggatttga aaacatgcca gctgcattta     2100

tgggaatgct gaaaggagat aatttgggga agacaatagt gaaagcatga aaaagaggac     2160

acatggaatc tggaggccat ttagatgatt agttaatttg tttttcacca tttagcaaaa     2220

atgtatacta ccttaaatgt cttaagaaat agtactcata atgagtttga gctacttaat     2280

aaaatacatt taagtggt                                                   2298


<210> 1912
<211> 1388
<212> DNA
<213> Homo sapiens

<400> 1912
tggcctgact cacaggacac taaggctcct tttctgaaga agccttttac cagtctcatt       60

taggggatgg gaacaacatg tcttcaccta gggactttag agcagagcct gtaaacgatt      120

atgagggaaa tgactctgaa gcagaagact tgaatttcag ggagactttg ccttcatcaa      180

gtcaggaaaa cacacctaga tcaaaggttt ttgaaaataa agttaattca gagaaggtaa      240

aactttctct tcggaatttc ccacataatg attatgagga tgtttttgaa gagccttcag      300

aaagtggcag tgatcccagc atgtggacag ccagaggccc cttcagaaga gacaggtgga      360

gcagtgagga tgaggaggct gcagggccat cacaggctct ctcccctcta ctttctgata      420

cgcgcaaaat tgtttctgaa ggagaactag atcagttggc tcagattcgg ccattaatat      480

tcaattttca tgagcagaca gccatcaagg attgtttgaa aatccttgag gaaaaaacag      540

cagcgtatga tatcatgcag gaatttatgg ctttagaact taagaatctg cctggtgagt      600

tcaactctgg gaatcaacca agcaacagag aaaaaaacag ataccgagat attcttccat      660

atgattcaac acgcgttcct cttggaaaaa gcaaggacta catcaatgct agttatatta      720

gaatagtcaa ttgtggagaa gagtattttt atatcgctac tcaaggacca ctgctgagca      780

ccatagatga cttttggcaa atggtgttgg aaaataattc aaatgttatt gccatgataa      840

ccagagagat agaaggtgga attatcaaat gctaccatta ctggcccatt tctctgaaga      900

agccattgga attgaaacac ttccgtgtat tcctggagaa ctaccagata cttcaatatt      960

tcatcattcg aatgtttcaa gttgtggaga agtccacggg aactagtcac tctgtaaaac     1020

agttgcagtt caccaagtgg ccagaccatg gcactcctgc ctcagcagat agcttcataa     1080

aatatattcg ttatgcaagg aagagccacc ttacaggacc catggttgtt cactgcagtg     1140

ccggcatagg ccggacaggg gtgttcctat gtgtggatgt cgtgttctgt gccatcgtaa     1200

agaactgttc attcaacatc atggatatag tggcccaaat gagagaacaa cgttctggca     1260

tggttcaaac gaaggagcag tatcactttt gttacgatat tgtgcttgaa gttcttcgga     1320

aacttctgac tttggattaa gaaagacttc tgttgcctct cacttgaaat taccaagtgg     1380

gtttgcac                                                              1388


<210> 1913
<211> 2539
<212> DNA
<213> Homo sapiens

<400> 1913
gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc ctgactcaca       60

ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg ggatgggaac      120

aacatgtctt cacctaggga ctttagagca gagcctgtaa acgattatga gggaaatgac      180

tctgaagcag aagacttgaa tttcagggag actttgcctt catcaagtca ggaaaacaca      240

cctagatcaa aggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg      300

aatttcccac ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat      360

cccagcatgt ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag      420

gaggctgcag ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt      480

tctgaaggag aactagatca gttggctcag attcggccat taatattcaa ttttcatgag      540

cagacagcca tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc      600

atgcaggaat ttatgacggg aactagtcac tctgtaaaac agttgcagtt caccaagtgg      660

ccagaccatg gcactcctgc ctcagcagat agcttcataa aatatattcg ttatgcaagg      720

aagagccacc ttacaggacc catggttgtt cactgcagtg ccggcatagg ccggacaggg      780

gtgttcctat gtgtggatgt cgtgttctgt gccatcgtaa agaactgttc attcaacatc      840

atggatatag tggcccaaat gagagaacaa cgttctggca tggttcaaac gaaggagcag      900

tatcactttt gttacgatat tgtgcttgaa gttcttcgga aacttctgac tttggattaa      960

gaaagacttc tgttgcctct cacttgaaat taccaagtgg gtttgcacct cctcataaag     1020

aacatgtttg cactgtgctg aagggctttg ctatgcatac aatctgcttt cttggtttat     1080

cagtttattt tctttctaaa agctccctga agggcaatat catttggctt ggggtgatca     1140

gtgtttactt attgatcttg ctagacaata tcaaaataac ttcccacatt ttccagtgaa     1200

acagatgtta cataaaacga ttgcagcttg gctatttggt tgaagggatt acagagccca     1260

ataaaggatt taaaatatat tcattaagat tttatttgga aaggtggctg gagagagctg     1320

aggatttcca ggactttgta agttcttatt ctgggagaac ataaggccaa taatcatgac     1380

ctcttccagg catttttaag acagatgtct attcatgttc tttagctaga gcctgtactt     1440

tttgctggca tttgaataac ccagtttaaa aagagtccag ttagggtgga ctaactttgg     1500

acacaaattg gcttccattt cctacatttt catactgctg ccttcctaca gctgctagac     1560

caagacctgt tggtctggga agcatttcat ggatagggag agctcctctc ggtgaacagt     1620

ccaaaactaa aatagatgtt tatatagaaa gcccaagagg agatttttgc catgcctgag     1680

ttctttccta tcccacccta acacttaaca tattacttag tctgctttgt taaaagcaag     1740

tattaccttt aacttgcctc ttactctttg ccctttagct aactaataaa gtttgatata     1800

ggcattatta tataattctg agtcattcat ggtatatctc atgtttgatg tatttttcaa     1860

actaagatct atgatagttt tttttccaga gttccattaa atcatttatt tcctttactt     1920

tctcacctct gttgaaacat ttagaaactg gatttgggaa cccaattttg gaaaaccaga     1980

ttcatagtca tgaaaatgga aacttccata ttctgttttt gaaaagatgt ggccattatt     2040

acagtaattt tattatagga ctttgcctcg tacaattaat agtgatattt tggacaagga     2100

gttctggtga caagctatac ctaattataa gctataaaac aatagatatg agtgtttgta     2160

cagtttaact caatggagat cagaatattc tatgtattga gaaaatgttt aatatcaatc     2220

tataaatctt gaatttctaa gaggcttatt ttgttctttt ggctgaatga gtatatttga     2280

attggttgaa taattaataa ttctcattgt aaaaataatt atatgccaaa aatatatttg     2340

atgttaaatc aaatagatga ttctgtttac attgttcata tgaataataa tctgtgttaa     2400

tttcattttg ataattggcc tttaatattt gtatctctaa ttttattttc tctctgttac     2460

tgtaaaataa tagctataat gtataacaat tttcttcaga agaattctat gctattatta     2520

aaataaaata tttactgtg                                                  2539


<210> 1914
<211> 2481
<212> DNA
<213> Homo sapiens

<400> 1914
gcgtggaccc aactggcgag gctgctgggg ttgcagcggg acagttgggg cggccccgca       60

ggcccaggtg aacaaaaatt gtttgctggc ccccaggata ctaactagac ctttggcctg      120

actcacagga cactaaggct ccttttctga agaagccttt taccagtctc atttagggga      180

tgggaacaac atgtcttcac ctagggactt tagagcagag cctgtaaacg attatgaggg      240

aaatgactct gaagcagaag acttgaattt cagggagact ttgccttcat caagtcagga      300

aaacacacct agatcaaagg tttttgaaaa taaagttaat tcagagaagg taaaactttc      360

tcttcggaat ttcccacata atgattatga ggatgttttt gaagagcctt cagaaagtgg      420

cagtgatccc agcatgtgga cagccagagg ccccttcaga agagacaggt ggagcagtga      480

ggatgaggag gctgcagggc catcacaggc tctctcccct ctactttctg atacgcgcaa      540

aattgtttct gaaggagaac tagatcagtt ggctcagatt cggccattaa tattcaattt      600

tcatgagcag acagccatca aggattgttt gaaaatcctt gaggaaaaaa cagcagcgta      660

tgatatcatg caggaattta tggctttaga acttaagaat ctgcctggtg agttcaactc      720

tgggaatcaa ccaagcaaca gagaaaaaaa cagataccga gatattcttc catttcaaca      780

tcatggatat agtggcccaa atgagagaac aacgttctgg catggttcaa acgaaggagc      840

agtatcactt ttgttacgat attgtgcttg aagttcttcg gaaacttctg actttggatt      900

aagaaagact tctgttgcct ctcacttgaa attaccaagt gggtttgcac ctcctcataa      960

agaacatgtt tgcactgtgc tgaagggctt tgctatgcat acaatctgct ttcttggttt     1020

atcagtttat tttctttcta aaagctccct gaagggcaat atcatttggc ttggggtgat     1080

cagtgtttac ttattgatct tgctagacaa tatcaaaata acttcccaca ttttccagtg     1140

aaacagatgt tacataaaac gattgcagct tggctatttg gttgaaggga ttacagagcc     1200

caataaagga tttaaaatat attcattaag attttatttg gaaaggtggc tggagagagc     1260

tgaggatttc caggactttg taagttctta ttctgggaga acataaggcc aataatcatg     1320

acctcttcca ggcattttta agacagatgt ctattcatgt tctttagcta gagcctgtac     1380

tttttgctgg catttgaata acccagttta aaaagagtcc agttagggtg gactaacttt     1440

ggacacaaat tggcttccat ttcctacatt ttcatactgc tgccttccta cagctgctag     1500

accaagacct gttggtctgg gaagcatttc atggataggg agagctcctc tcggtgaaca     1560

gtccaaaact aaaatagatg tttatataga aagcccaaga ggagattttt gccatgcctg     1620

agttctttcc tatcccaccc taacacttaa catattactt agtctgcttt gttaaaagca     1680

agtattacct ttaacttgcc tcttactctt tgccctttag ctaactaata aagtttgata     1740

taggcattat tatataattc tgagtcattc atggtatatc tcatgtttga tgtatttttc     1800

aaactaagat ctatgatagt tttttttcca gagttccatt aaatcattta tttcctttac     1860

tttctcacct ctgttgaaac atttagaaac tggatttggg aacccaattt tggaaaacca     1920

gattcatagt catgaaaatg gaaacttcca tattctgttt ttgaaaagat gtggccatta     1980

ttacagtaat tttattatag gactttgcct cgtacaatta atagtgatat tttggacaag     2040

gagttctggt gacaagctat acctaattat aagctataaa acaatagata tgagtgtttg     2100

tacagtttaa ctcaatggag atcagaatat tctatgtatt gagaaaatgt ttaatatcaa     2160

tctataaatc ttgaatttct aagaggctta ttttgttctt ttggctgaat gagtatattt     2220

gaattggttg aataattaat aattctcatt gtaaaaataa ttatatgcca aaaatatatt     2280

tgatgttaaa tcaaatagat gattctgttt acattgttca tatgaataat aatctgtgtt     2340

aatttcattt tgataattgg cctttaatat ttgtatctct aattttattt tctctctgtt     2400

actgtaaaat aatagctata atgtataaca attttcttca gaagaattct atgctattat     2460

taaaataaaa tatttactgt g                                               2481


<210> 1915
<211> 3060
<212> DNA
<213> Homo sapiens

<400> 1915
ggacgcctgg tgttctcgcg ggaaagaacc gttgcgcccg actttgcgcg gaggtaggag       60

ggggaagtgg aggcgggagt gaagtctcgc gagaagagtc ggttgccgta gcagagccct      120

ctagctgtgt gtgtctgagg ctcggccgcc tgagccgcgg acggtttgct gagcccgtta      180

gtgcgcccgg ccgagacacg ccgccgccat gtcccgctac ctgcgtcccc ccaacacgtc      240

tctgttcgtc aggaacgtgg ccgacgacac caggtctgaa gacttgcggc gtgaatttgg      300

tcgttatggt cctatagttg atgtgtatgt tccacttgat ttctacactc gccgtccaag      360

aggatttgct tatgttcaat ttgaggatgt tcgtgatgct gaagacgctt tacataattt      420

ggacagaaag tggatttgtg gacggcagat tgaaatacag tttgcccagg gggatcgaaa      480

gacaccaaat cagatgaaag ccaaggaagg gaggaatgtg tacagttctt cacgctatga      540

tgattatgac agatacagac gttctagaag ccgaagttat gaaaggagga gatcaagaag      600

tcggtctttt gattacaact atagaagatc gtatagtcct agaaacagta gaccgactgg      660

aagaccacgg cgtagcagaa gccattccga caatgataga ttcaaacacc gaaatcgatc      720

tttttcaaga tctaaatcca attcaagatc acggtccaag tcccagccca agaaagaaat      780

gaaggctaaa tcacgttcta ggtctgcatc tcacaccaaa actagaggca cctctaaaac      840

agattccaaa acacattata agtctggctc aagatatgaa aaggaatcaa ggaaaaaaga      900

accacctaga tccaaatctc agtcaagatc acagtctagg tctaggtcaa aatctagatc      960

aaggtcttgg actagtccta agtccagtgg ccactgatag tataaaccat ggtcattttt     1020

aggcatgtat cattcattta ctcatagttt ggtttactta aattatcagg aatacaatgt     1080

tgcaatgatg cttaaaaaac acttgttagt tttccctgta ccaggcaatg gttataatta     1140

aaatgatatg ctgttgagaa gccactctta agagtccagt ttgtttaatg ttatgggcag     1200

ctaccaattt gtggtgtctc tgtatatttt tgtaaagatt ctcatttttt atgcttgaag     1260

tatttggtga aaagatgttg gttgaccata atttgcaaca ttgtctcatt aaaaataaac     1320

tttcatattc atatttggta gaactgttaa cctagaaatg tagcttgcta ataagataga     1380

atgatacaaa agtgaagtag tagccacagt acaacactga ctgctcagac acatttaggt     1440

tcagggtgga cctttatgtc ttgtcaagat gtctaggccc ggctgggcgt ggtggctcac     1500

acctgtaatc ccagcacttt gggaggctga ggcgggcgga tcacgaggtc aggagttcga     1560

gaccagcctg accaacacgg tgaaaccccg tctctactaa aaatacaaaa attatccggg     1620

catggtggca catgcctgta atctcagcta ctcaggaggc tgaggcaaga gaatcgcttg     1680

aacctgggag gtagaagttg cagtgagcca aaatcacgcc actgcactcc agcctgggca     1740

acagagtgag actccgtctc aaaaaaaaaa aaaaaaaaac cggatgtcta ggccaatgat     1800

aattattttt gatgcagtgt ggattagttc ttttgttaac cccactgtct tggggaatga     1860

tgccagctgg gaaattgagt ttttgactga aacatggagc cttcactgct ttttttctgg     1920

ttcctatgaa gatttggaac atagaaaaca caaaaactca ccttaaaatt tgagcaggtc     1980

gttgatggca aaaataattt taaggaaaaa ggaatattct tatgtagtta ttctaaagtt     2040

taaggagcgt tgttgaccat aatattgctt agttttctta ctgctgttaa gtaagtaaat     2100

tgtttcaaag taggttttgt gtgtgtgtgc ctagtgtaaa agaactgaaa ttttgatgct     2160

tacagcactt ggctcgtgca tttgtatcaa aatttgcctg cctctttatg agggaggcct     2220

gcttttcaca cctcagttta tttaatacga ggcaagttgt aagacaacac tcattctagg     2280

tgattctgtg gtgccatgaa atttaaggta atttggggaa aaggattagt cagttttaag     2340

caagagtcac atcttttgag ctttcgatta tcagtgtagt acctgactaa aaatgaagta     2400

atacccttaa accatttata atttctagta tttctctgaa agatcgtttt ggggacaaaa     2460

gtgacttgac atgtccaatt tcatttcaga ataaaaagct agcatcttta aaaatctcag     2520

attgcttgct tacagataca agtaagaatt atggacaaac gattcctttt agaggattac     2580

ttttttcaat ttcggtttta gtaatctagg ctttgcctgt aaagaataca acgatggatt     2640

ttaaatactg tttgtggaat gtgtttaaag gattgattct agaacctttg tatatttgat     2700

agtatttcta actttcattt ctttactgtt tgcagttaat gttcatgttc tgctatgcaa     2760

tcgtttatat gcacgtttct ttaatttttt tagattttcc tggatgtata gtttaaacaa     2820

caaaaagtct atttaaaact gtagcagtag tttacagttc tagcaaagag gaaagttgtg     2880

gggttaaact ttgtattttc tttcttatag aggcttctaa aaaggtattt ttatatgttc     2940

tttttaacaa atattgtgta caacctttaa aacatcaatg tttggatcaa aacaagaccc     3000

agcttatttt ctgcttgctg taaattaagc aaacatgcta taataaaaac aaaatgaagg     3060


<210> 1916
<211> 2205
<212> DNA
<213> Homo sapiens

<400> 1916
ggacgcctgg tgttctcgcg ggaaagaacc gttgcgcccg actttgcgcg gaggtaggag       60

ggggaagtgg aggcgggagt gaagtctcgc gagaagagtc ggttgccgta gcagagccct      120

ctagctgtgt gtgtctgagg ctcggccgcc tgagccgcgg acggtttgct gagcccgtta      180

gtgcgcccgg ccgagacacg ccgccgccat gtcccgctac ctgcgtcccc ccaacacgtc      240

tctgttcgtc aggaacgtgg ccgacgacac caggtctgaa gacttgcggc gtgaatttgg      300

tcgttatggt cctatagttg atgtgtatgt tccacttgat ttctacactc gccgtccaag      360

aggatttgct tatgttcaat ttgaggatgt tcgtgatgct gaagacgctt tacataattt      420

ggacagaaag tggatttgtg gacggcagat tgaaatacag tttgcccagg gggatcgaaa      480

gacaccaaat cagatgaaag ccaaggaagg gaggaatgtg tacagttctt cacgctatga      540

tgattatgac agatacagac gttctagaag ccgaagttat gaaaggagga gatcaagaag      600

tcggtctttt gattacaact atagaagatc gtatagtcct agaaacagta gaccgactgg      660

aagaccacgg cgtagcagaa gccattccga caatgatagc caagtaagca agaagaaaaa      720

tgagagataa tgcttcagtg agagaggaaa ggtgctacat agagtatgag ctgttaagtt      780

acaacccagg ggaaagacct gggaactatt gtattattct cttgaaaatt tggcccagta      840

agctgctaca tccagttcaa ctaacaaaat cctgtatacc acagagaaga ataaagaaaa      900

ccaaactgac aaacatcctt cttttattta agaccaaact gcagctggaa tacccagtac      960

agttctgctt actacacttc aagaaagatc tgaaagcgga aaaagaacca aagaagggca     1020

gttcaagcga ccaaagggtg ggtggaaggt gctgcagtat gaatactgta cgaatatttt     1080

gactctggtc tgaaaagata aaagaatgtt atcgaaaact acatggaata attgaagtcc     1140

cttcaagttt gaaagtaagc attttaggac aaataaaagg aaattcaact ttgtacttgt     1200

ggaaactaat ccctaaatat gaataggttt atattgattc atgggtaaca ggtccataat     1260

aaattattgg aaactaggat gtctgaatat caaggaagac agccatagtc tcttacagtg     1320

cctctgttgg tctgtctcaa actgaattgg gtgggaaaag gtatggtcca atataaaagt     1380

tccatttttg ccattattgg caaatcttgc ctttgtttat tttggtgcca gtgttttctg     1440

cttaatcatt tgctttgttg gcatctgtgt ttatttactt gtacaccaca tgcagtttac     1500

atctgtctta actactcctt cccaggtaaa ttccaattat atttgacatc cagctaagag     1560

ggcccatctc ttctcacctc tttcctagtc agtatattca gcaaatattt attgagccct     1620

tactgtgggc aaatcattgt actggataat tgagaaaaat agataattcc cttattcagt     1680

aaatgtctac tgagcacaat ctagtgaatc attacagtat ggcctcattg ttttgtttga     1740

ggtgtgttat tcataacaat attttacacc attcgtatca atgtaattat agaacacaat     1800

atacgatcaa ggataagtaa ttgtgtggtt atctgccatt taaaagtatc cagtatttga     1860

tcacattatt ataaataatg aaaaaatgat ttaatctgta ataaactggt ttattgtgca     1920

gtgactgtaa tatactagag ttataataaa ttgtttactc tgcctcacca aacacatgct     1980

aggatataac ccccaaaata agtatttaac tttgcattag gtataaagga gactgggtgc     2040

tataattaga ttattttgag gcagacagag agctgttatc ctaactgatt tagtatgttc     2100

tgtaattgag aaaatgttca ccaaattata ctttttagtg atttacatgt acattttata     2160

ggggacatgt tctgtgtata gcgaataaat aacttttata gtatc                     2205


<210> 1917
<211> 1074
<212> DNA
<213> Homo sapiens

<400> 1917
caggctgagc gttggaagcc attttggctg caacctacct gaagcgatgt ctgcctttgg       60

tcacgacgag gcctggatgg aggccggagg ctttggtctg gaggctgccg aaagaacgga      120

ataccagtct ctgtgcaaat ctaaactctt attcctggga gagcagagcg tagggaagac      180

atccatcatc agccgcttca tgtacaacag cttcggctgc gcctgccagg caactgttgg      240

aattgacttc ttgtctaaga ccatgtactt ggaggaccaa atagttcagc tgcagctatg      300

ggacacagct ggccaggagc gctttcacag cctaattcct agctacattc gtgattcaac      360

tattgcagtg gttgtctatg acattacaaa catcaattct tttaaggaga cagataagtg      420

ggtagaacac gtgcgagcag aaagaggtga cgatgttgtc atcatgttgt tgggtaacaa      480

gattgatttg gataacaaaa gacaagtcac tgcagaacag ggtgaagaaa aatccagaaa      540

cctcaatgtg atgtttattg agaccagtgc caaaaccggt tacaacgtga aaaagctgtt      600

ccggcgtgtg gcttctgccc ttctttccac aaggacttca cctccaccaa aagaggggac      660

ggttgaaatc gaactggaat ccttcgagga gtcaggcaac agaagctatt gttgacagct      720

taggctttct ctgcctcatt tgatggattt cttacatttg ggcttgccat accagttctc      780

ctccccacct cgttttatga tacatggcca cttactctct tccaattcct aggcttgggg      840

taaaaacaga acccctgaaa gtgctatcat tttttcctga ccgcatctca cagctactgg      900

gtggaagctt cttgcagcac ctgggaattc taccttacct tctccgacag ctaaaagaca      960

tctgtagaga atacagttct acagcagctg acatacttca aaggccaata caattcattc     1020

tccactgttt gttgttgttt acctacaccc tcaataaatg gttctttaac ctaa           1074


<210> 1918
<211> 453
<212> DNA
<213> Homo sapiens

<400> 1918
cctggtgtaa tcatggtaca gattattaaa gacacgaatg aatttaaaac atttttgaca       60

gctgccggac acaaactcgc agtggttcaa ttttcttcga aacggtgtgg tccctgcaaa      120

aggatgtttc ctgttttcca tgctatgtct gtgaaatacc aaaatgtatt ttttgctaat      180

gtggatgtga acaattctcc ggagctggct gaaacttgtc acatcaaaac aatacccaca      240

tttcagatgt tcaagaaaag ccagaaggta accctattct caagaatcaa aagaataatt      300

tgctgttata gaagtggatt catgagcaac ctgtgtcttg cagatgatgg aaatgagtag      360

gatttaactt ttcaatcagg aataaaattc cttaaagcct caacattttc gcagcacttg      420

aatcaataaa tgtttcacct ttgtgcattt gtg                                   453


<210> 1919
<211> 433
<212> DNA
<213> Homo sapiens

<400> 1919
tccaactaaa ccaacagggg attttcatca gcacttccct ggtgtaatca tggtacagat       60

tattaaagac acgaatgaat ttaaaacatt tttgacagct gccggacaca aactcgcagt      120

ggttcaattt tcttcgaaac ggtgtggtcc ctgcaaaagg atgtttcctg ttttccatgc      180

tatgtctgtg aaataccaaa atgtattttt tgctaatgtg gatgtgaaca attctccgga      240

gctggctgaa acttgtcaca tcaaaacaat acccacattt cagatgttca agaaaagcca      300

gaaggtaacc ctattctcaa gaatcaaaag aataatttgc tgttatagaa gtggattcat      360

gagcaacctg atttttgagt tttgtggagc cgatgctaaa aaattggaag ccaagactca      420

agaattaatg taa                                                         433


<210> 1920
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 1920
tcgccgcccg ccccgctgct gtctggcggg ggaggagctc gggaccggga gcagcggctc       60

tggcggtcgt ggcggtcgga gatccgagag ctctgcttct ctgaaaagcg tgtggctttc      120

tggacttgtt tcaggccacc cacgagccag cgggaaagga ttgccagcca gagaaagacg      180

aactccgaag tcccaatgca cagatcagcc cccagtcaaa ccaccaagag gagccgatcg      240

ccattttcca ctactcgtcg tagttgggac gacagcgaga gttcgggaac caacctgaat      300

attgataatg aggactattc caggtatccg ccaagagagt acagagcttc gggtagcaga      360

agaggaatgg cctatggaca tattgactct tatggggcag atgatagtga ggaggagggg      420

gctgggcctg ttgagcgacc gccagtgaga gggaaaactg gcaagtttaa agatgataag      480

ctgtatgacc cagagaaagg ggcaaggtct ttggctgggc cacctccaca tttctctagt      540

tttagccgtg atgtgagaga ggagcgagac aagttagacc cagtccctgc agcaagatgc      600

tcagctagca gagctgactt cctgccacaa agtagtgtgg cctcacagtc gtcttctgaa      660

ggcaagctgg ctacaaaagg tgacagctcg gagagggaga gaagggagca aaatttacct      720

gcacgtccca gcagggctcc tgtgagtatt tgtggtggtg gggaaaacac ctcaaagagt      780

gcagaggaac ctgtggtcag gcccaaaatc agaaacctgg caagtccaaa ctgcgtgaaa      840

ccaaaaattt tttttgatac tgatgatgat gacgatatgc cacacagtac ttccaggtgg      900

agggataccg ccaatgacaa tgagggccac tcggatggcc tggcaagaag agggagaggc      960

gagagttcaa gtggctatcc cgagccaaag taccctgaag acaaacggga agcgaggagt     1020

gaccaagtga aaccagaaaa ggtgccgaga cgacgacgca ccatggccga ccctgacttc     1080

tggacgcaca gtgatgatta ctacaaatac tgcgacgaag actctgacag tgacaaagag     1140

tggattgctg ctctgcgtcg gaaatatcga agccgagagc aaaccctgtc ctccagtggc     1200

gaaagctggg agactctgcc ggggaaagaa gagcgggaac ctccacaggc taaggtgagt     1260

gccagcactg gcaccagccc tggccccggt gctagtgcca gtgccggggc tggcgccggg     1320

gccagtgctg gcagcaatgg cagcaattac cttgaagaag ttcgagaacc atctcttcag     1380

gaagagcagg catccctgga agaaggagaa attccttggc tccagtacca tgagaatgac     1440

agtagcagtg agggggataa tgattctggt cacgagttga tgcaacctgg ggtattcatg     1500

ctggatggaa acaacaacct tgaagatgac tccagtgtga gcgaagacct agaagtggat     1560

tggagcctct ttgatggatt tgcagatggg ttaggagtgg ctgaagccat ttcctatgtg     1620

gaccctcagt tcctcaccta catggcactt gaagaacgcc tggcccaggc aatggaaact     1680

gcccttgcgc acttggagtc tctcgcagtg gatgtagagg tggccaatcc accagcaagc     1740

aaggagagca ttgacgctct tcccgagatc ctggtcactg aagatcatgg cgcagttggt     1800

caggagatgt gctgccccat ctgctgtagc gaatatgtga agggggaggt ggcaactgag     1860

ctgccgtgcc accactattt ccacaagccg tgtgtgtcca tctggcttca gaagtcaggc     1920

acctgccccg tgtgccgctg catgttccct cccccactct aaagaccaag gccgtttact     1980

cctggtctga ttattttccc catctgaaat ccacaatact gcaggagccc tcttgaaatt     2040

aacaatggaa ataaaaccaa tcagtcagtt agcctaaacc tattgattcc tcgtgattat     2100

ttccaatgtg aaaacagttg tgtatgattg cattaaaaat catatcatct tttagaggtt     2160

agaaaaggga aaactaaact ttctaaatgc tacttgagat tgcagtaaga agatacgttt     2220

tctaacctga aagttaaatc gcatttgttt tcttcagtag aatgggaatg tgttgctgtt     2280

acttgtaatg tcaagtttat ctgttaaata tgtccaaaag gcaaaatcat ttttgttgca     2340

tgttatgggt cgatgttcct gtaattgcag tgccgtaa                             2378


<210> 1921
<211> 736
<212> DNA
<213> Homo sapiens

<400> 1921
gtgcggaggg gcggggcgtg tggaggccgg gacggcgccc ccggccggcg gtgaggccgg       60

ctcagcgcgg agcagctcag tgccccccgc gccccgctcc ggcagctcca cgctcgcgcc      120

cgccatgccg gagcagttca gcgtcgccga gttcctggcc gtcaccgcgg aggacctcag      180

ctccccggct ggggccgccg ccttcgccgc caagatgccc cggtaccgag gggcggcgct      240

ggcgcgggag gagatcttgg aaggagacca agccatcctg cagagaataa agaaggctgt      300

gcgggcaatc catagctccg gccttggcca tgtggagaat gaagagcagt accgagaggc      360

cgtggaatcc ttaggcaaca gccacctgtc ccagaacagc catgagctgt ccacaggctt      420

cctaaacttg gccgtgttca cccgcgaggt tgctgcgctc ttcaagaacc tgattcagaa      480

cttgaacaac attgtctctt tccccctgga cagtctgatg aaggggcagc tgagggacgg      540

tcgacaggat tccaaaaaac agctggagaa ggcatggaag gactatgaag ccaaaatggc      600

caagctggag aaggagcgcg atcgggccag ggtgacagga gggatccctg cttggaacct      660

ggggatccca gccaagcccc acccaactct gaagagggcc tccgagagcc cccaggcacc      720

tccagaccca gcctga                                                      736


<210> 1922
<211> 2692
<212> DNA
<213> Homo sapiens

<400> 1922
gtcagattct cctctaagtc tggctttcct gcaaacccag tcttgtaatc attttgccaa       60

cattaaaaat gtgttccagg tctacacctg acagtcactg gaatgctact ccaggcctta      120

gaagaaagtg aaactaattt taaaggcccc ttattctttc tgttacctgc ctgctgaagt      180

gaaaataaat ctccctgctc ctttattcta aactgatttt actttcccat ctcaaaaacg      240

tgtgcaggga gcaggagccc tcctacccga gccccagctg tattggaaac cctcctaagt      300

cagagtgatg ggtcaggaat ctagcaagcc tgtatggccc aatccaacag gagggtatca      360

gtccaataca ggtaggaggt atggaagaag gcatgcttat gtcagtttca ggccacccac      420

gagccagcgg gaaaggattg ccagccagag aaagacgaac tccgaagtcc caatgcacag      480

atcagccccc agtcaaacca ccaagaggag ccgatcgcca ttttccacta ctcgtcgtag      540

ttgggacgac agcgagagtt cgggaaccaa cctgaatatt gataatgagg actattccag      600

gtatccgcca agagagtaca gagcttcggg tagcagaaga ggaatggcct atggacatat      660

tgactcttat ggggcagatg atagtgagga ggagggggct gggcctgttg agcgaccgcc      720

agtgagaggg aaaactggca agtttaaaga tgataagctg tatgacccag agaaaggggc      780

aaggtctttg gctgggccac ctccacattt ctctagtttt agccgtgatg tgagagagga      840

gcgagacaag ttagacccag tccctgcagc aagatgctca gctagcagag ctgacttcct      900

gccacaaagt agtgtggcct cacagtcgtc ttctgaaggc aagctggcta caaaaggtga      960

cagctcggag agggagagaa gggagcaaaa tttacctgca cgtcccagca gggctcctgt     1020

gagtatttgt ggtggtgggg aaaacacctc aaagagtgca gaggaacctg tggtcaggcc     1080

caaaatcaga aacctggcaa gtccaaactg cgtgaaacca aaaatttttt ttgatactga     1140

tgatgatgac gatatgccac acagtacttc caggtggagg gataccgcca atgacaatga     1200

gggccactcg gatggcctgg caagaagagg gagaggcgag agttcaagtg gctatcccga     1260

gccaaagtac cctgaagaca aacgggaagc gaggagtgac caagtgaaac cagaaaaggt     1320

gccgagacga cgacgcacca tggccgaccc tgacttctgg acgcacagtg atgattacta     1380

caaatactgc gacgaagact ctgacagtga caaagagtgg attgctgctc tgcgtcggaa     1440

atatcgaagc cgagagcaaa ccctgtcctc cagtggcgaa agctgggaga ctctgccggg     1500

gaaagaagag cgggaacctc cacaggctaa ggtgagtgcc agcactggca ccagccctgg     1560

ccccggtgct agtgccagtg ccggggctgg cgccggggcc agtgctggca gcaatggcag     1620

caattacctt gaagaagttc gagaaccatc tcttcaggaa gagcaggcat ccctggaaga     1680

aggagaaatt ccttggctcc agtaccatga gaatgacagt agcagtgagg gggataatga     1740

ttctggtcac gagttgatgc aacctggggt attcatgctg gatggaaaca acaaccttga     1800

agatgactcc agtgtgagcg aagacctaga agtggattgg agcctctttg atggatttgc     1860

agatgggtta ggagtggctg aagccatttc ctatgtggac cctcagttcc tcacctacat     1920

ggcacttgaa gaacgcctgg cccaggcaat ggaaactgcc cttgcgcact tggagtctct     1980

cgcagtggat gtagaggtgg ccaatccacc agcaagcaag gagagcattg acgctcttcc     2040

cgagatcctg gtcactgaag atcatggcgc agttggtcag gagatgtgct gccccatctg     2100

ctgtagcgaa tatgtgaagg gggaggtggc aactgagctg ccgtgccacc actatttcca     2160

caagccgtgt gtgtccatct ggcttcagaa gtcaggcacc tgccccgtgt gccgctgcat     2220

gttccctccc ccactctaaa gaccaaggcc gtttactcct ggtctgatta ttttccccat     2280

ctgaaatcca caatactgca ggagccctct tgaaattaac aatggaaata aaaccaatca     2340

gtcagttagc ctaaacctat tgattcctcg tgattatttc caatgtgaaa acagttgtgt     2400

atgattgcat taaaaatcat atcatctttt agaggttaga aaagggaaaa ctaaactttc     2460

taaatgctac ttgagattgc agtaagaaga tacgttttct aacctgaaag ttaaatcgca     2520

tttgttttct tcagtagaat gggaatgtgt tgctgttact tgtaatgtca agtttatctg     2580

ttaaatatgt ccaaaaggca aaatcatttt tgttgcatgt tatgggtcga tgttcctgta     2640

attgcagtgc cgtaaaagct tattaaagtt gttcttttgg ttttacatgg ta             2692


<210> 1923
<211> 2115
<212> DNA
<213> Homo sapiens

<400> 1923
gcggtcgtgg cggtcggaga tccgagagct ctgcttctct gaaaagcgtg tggctttctg       60

gacttggtct acacctgaca gtcactggaa tgctactcca ggccttagaa gaaagtgaaa      120

ctaattttaa aggcccctta ttctttctgt tacctgcctg ctgaagtgaa aataaatctc      180

cctgctcctt tattctaaac tgattttact ttcccatctc aaaaacgtgt gcagggagca      240

ggagccctcc tacccgagcc ccagctgtat tggaaaccct cctaagtcag agtgatgggt      300

caggaatcta gcaagcctgt atggcccaat ccaacaggag ggtatcagtc caatacaggt      360

aggaggtatg gaagaaggca tgcttatgtc agtttcaggc cacccacgag ccagcgggaa      420

aggattgcca gccagagaaa gacgaactcc gaagtcccaa tgcacagatc agcccccagt      480

caaaccacca agaggagccg atcgccattt tccactactc gtcgtagttg ggacgacagc      540

gagagttcgg gaaccaacct gaatattgat aatgaggact attccagtac ttccaggtgg      600

agggataccg ccaatgacaa tgagggccac tcggatggcc tggcaagaag agggagaggc      660

gagagttcaa gtggctatcc cgagccaaag taccctgaag acaaacggga agcgaggagt      720

gaccaagtga aaccagaaaa ggtgccgaga cgacgacgca ccatggccga ccctgacttc      780

tggacgcaca gtgatgatta ctacaaatac tgcgacgaag actctgacag tgacaaagag      840

tggattgctg ctctgcgtcg gaaatatcga agccgagagc aaaccctgtc ctccagtggc      900

gaaagctggg agactctgcc ggggaaagaa gagcgggaac ctccacaggc taaggtgagt      960

gccagcactg gcaccagccc tggccccggt gctagtgcca gtgccggggc tggcgccggg     1020

gccagtgctg gcagcaatgg cagcaattac cttgaagaag ttcgagaacc atctcttcag     1080

gaagagcagg catccctgga agaaggagaa attccttggc tccagtacca tgagaatgac     1140

agtagcagtg agggggataa tgattctggt cacgagttga tgcaacctgg ggtattcatg     1200

ctggatggaa acaacaacct tgaagatgac tccagtgtga gcgaagacct agaagtggat     1260

tggagcctct ttgatggatt tgcagatggg ttaggagtgg ctgaagccat ttcctatgtg     1320

gaccctcagt tcctcaccta catggcactt gaagaacgcc tggcccaggc aatggaaact     1380

gcccttgcgc acttggagtc tctcgcagtg gatgtagagg tggccaatcc accagcaagc     1440

aaggagagca ttgacgctct tcccgagatc ctggtcactg aagatcatgg cgcagttggt     1500

caggagatgt gctgccccat ctgctgtagc gaatatgtga agggggaggt ggcaactgag     1560

ctgccgtgcc accactattt ccacaagccg tgtgtgtcca tctggcttca gaagtcaggc     1620

acctgccccg tgtgccgctg catgttccct cccccactct aaagaccaag gccgtttact     1680

cctggtctga ttattttccc catctgaaat ccacaatact gcaggagccc tcttgaaatt     1740

aacaatggaa ataaaaccaa tcagtcagtt agcctaaacc tattgattcc tcgtgattat     1800

ttccaatgtg aaaacagttg tgtatgattg cattaaaaat catatcatct tttagaggtt     1860

agaaaaggga aaactaaact ttctaaatgc tacttgagat tgcagtaaga agatacgttt     1920

tctaacctga aagttaaatc gcatttgttt tcttcagtag aatgggaatg tgttgctgtt     1980

acttgtaatg tcaagtttat ctgttaaata tgtccaaaag gcaaaatcat ttttgttgca     2040

tgttatgggt cgatgttcct gtaattgcag tgccgtaaaa gcttattaaa gttgttcttt     2100

tggttttaca tggta                                                      2115


<210> 1924
<211> 740
<212> DNA
<213> Homo sapiens

<400> 1924
gggtttatta ctactgaagg aagaacgtga gtaggttagg atttcggttg agaggcttgg       60

ggtcttgcgt ttcgcccacc atctcctggg gacagggtgg agtcgatatc cgggacgggg      120

gggaggttgc ggtgcccctc agggctacct ctcaagagtg ctatcatttc cgcaggccag      180

atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac      240

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      300

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      360

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      420

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      480

ggccacagta gggaagaggc tggactatat cacagctgaa attaagcgat acgaatccca      540

gcttcgggat cttgagcggc agtcagagca acagagggag acccttgctc agctgcagca      600

ggagttccag cgggcccagg cagcaaaggc aggggctcct ggcaaggcct gaccccatgg      660

tggggggagg ggaggggagg ggagggaatg aggcagctct aggatctata ctgtagctaa      720

taaaatgtaa aaacacctgg                                                  740


<210> 1925
<211> 581
<212> DNA
<213> Homo sapiens

<400> 1925
attactactg aaggaagaac gtgagtaggc cagatcagaa aagggagctc aggtaccttc       60

cagagagtga gacccagcgc ccttgtctcg cacccagtag gctttcatcc ccgccatggc      120

ggagctgatc cagaagaagc tacagggaga agtggagaaa tatcaacagc tacagaagga      180

cttaagtaaa tccatgtcgg ggaggcagaa acttgaagca caactaacag aaaataatat      240

cgtgaaagag gaactggccc tgctggatgg gtccaacgtg gtctttaaac ttctgggtcc      300

ggtgctagtc aaacaggagc tgggggaggc tcgggccaca gtagggaaga ggctggacta      360

tatcacagct gaaattaagc gatacgaatc ccagcttcgg gatcttgagc ggcagtcaga      420

gcaacagagg gagacccttg ctcagctgca gcaggagttc cagcgggccc aggcagcaaa      480

ggcaggggct cctggcaagg cctgacccca tggtgggggg aggggagggg aggggaggga      540

atgaggcagc tctaggatct atactgtagc taataaaatg t                          581


<210> 1926
<211> 521
<212> DNA
<213> Homo sapiens

<400> 1926
gtttattact actgaaggaa gaacgtgagt agatcagaaa agggagctca ggtaccttcc       60

agagagtgag acccagcgcc cttgtctcgc acccagtagg ctttcatccc cgccatggcg      120

gagctgatcc agaagaagct acagggagaa gtggagaaat atcaacagct acagaaggac      180

ttaagtaaat ccatgtcggg gaggcagaaa cttgaagcac aactaacaga aaataatatc      240

gtgaaagagg aactggccct gctggatggg tccaacgtgg tctttaaact tctgggtccg      300

gtgctagtca aacaggagct gggggaggct cgggccacag tagggaagag gctggactat      360

atcacagctg aaattaagcg atacgaatcc cagcttcggg atcttgagcg gcagtcagag      420

caacagaggg agacccttgc tcagctgcag caggagttcc agcgggccca ggcagcaaag      480

gcaggggctc ctggcaaggc ctgaccccat ggtgggggga g                          521


<210> 1927
<211> 1760
<212> DNA
<213> Homo sapiens

<400> 1927
attggccgag cgcggccgtt gggggtgagg ccgcgtcggg ggaggacaac aaagggccgc       60

gggcggcggg cagtggtgtc ccagtctccc ggtgcttccc tgaggctgag gcgcccggcc      120

tcccgcccgc cgcgctccag atgaagtgtg agcactgcac gcgcaaggaa tgtagtaaga      180

aaacaaaaac tgatgaccaa gagaatgtgt cagccgatgc accgagtcca gcccaggaaa      240

atggagagaa gggagaattc cacaagttgg ctgatgccaa gatatttttg agcgactgcc      300

tggcatgtga cagctgtatg actgcagagg aaggagtcca actttcccag caaaatgcca      360

aggacttctt ccgcgttctg aaccttaaca agaaatgtga tacctcaaag cacaaagtgc      420

tggtagtgtc tgtgtgtcct caatctttgc cttattttgc tgctaaattc aacctcagtg      480

taactgatgc atccagaaga ctctgtggtt tcctcaaaag tcttggggtg cactatgtat      540

ttgatacgac gatagctgcg gattttagta tcctggagag tcaaaaagaa ttcgtgcgtc      600

gctatcgcca gcacagtgag gaggaacgca ccctgcccat gctgacctct gcctgtcctg      660

gctgggtccg atacgccgag cgggtgctgg gtcgccccat cactgcccac ctctgcaccg      720

ccaagtcccc ccagcaggtc atgggctctt tggtgaagga ttatttcgcc agacagcaga      780

acctgtctcc agagaagatt ttccacgtca ttgtggcccc ttgttatgac aagaagctgg      840

aggctcttca ggaaagcctt ccccctgctt tgcatggctc ccggggcgct gactgcgtgt      900

taacatcagg taaggtactt atctcttggt ggtgcacacc tgtaatcaca gctactcagg      960

aggctgcggc aagagaatca cttgaacccg ggaggcagag gttacagcga gacaagattg     1020

caccactgga ctccagcctg ggcggcggag gtgaaattgc tcaaataatg gagcaaggtg     1080

acctctcagt gagagatgct gccgtcgaca ctctgtttgg agacttgaag gaggacaaag     1140

tgacgcgtca tgatggagcc agctcagacg ggcacctggc acacatcttc agacatgcgg     1200

ccaaggagct gttcaacgag gatgtggagg aggtcactta ccgagccctg agaaacaaag     1260

acttccaaga ggtcaccctt gagaagaacg gagaggtggt gttacgcttt gctgcagcct     1320

atggctttcg aaacatccag aacatgatcc tgaagcttaa gaagggcaag ttcccattcc     1380

actttgtgga ggtcctcgcc tgtgctggag gatgcttaaa tggcagaggc caagcccaga     1440

ctccagacgg acatgcggat aaggccctgc tgcggcagat ggaaggcatt tacgctgaca     1500

tccctgtgcg gcgtccggag tccagtgcac acgtgcagga gctgtaccag gagtggctgg     1560

aggggatcaa ctcccccaag gcccgagagg tgctgcatac cacgtaccag agccaggagc     1620

gtggcacaca cagcctggac atcaagtggt gaagtcaggc cagggccttc cagctgctct     1680

tggggccaga gccaagagcc tctcagtaga gggaggggct gccctgagtg gagtattaaa     1740

gacacttaag aaaaccgctc                                                 1760


<210> 1928
<211> 499
<212> DNA
<213> Homo sapiens

<400> 1928
atggctaccg agcccgaagc cgcggagccg gtggtgcctt cgctcgtgga tcgatacttc       60

actcgctggt acaaaccgga tgtcaaagga aaattttgtg aggaccactg tatactacag      120

cactctaacc gaatatgtgt catcacattg gcagaatctc atccagttct tcaaagtgga      180

aaaacaatta aaagcatttc ctatcagatc agtaccaact gtagcagact tcagaacaag      240

gtctctggga aatttaagcg gagaattatc tatctagaaa aggtagaaga cgtcatcaag      300

aggaaaatga tgcctctaag cttgggactg catcttcccc actcttaatc ctccttctat      360

aggaaggaat cttcacgagc acaggatccc tcacttctgt ctgctgcctc acctatccca      420

tcccataaaa ggaggtggat gctcatcttt tcagtctttc tggtgacttt gcaaaaataa      480

attgaacaca ttaaccctt                                                   499


<210> 1929
<211> 3037
<212> DNA
<213> Homo sapiens

<400> 1929
aattgagatg gtttactgta aaattaaaat gggagttagt tttctagaca tgtaactctc       60

tggggagtat aaaactggtc acaatgggct ttgcgttgaa gtatctgtcc ctcagatctc      120

atcagaagga gtatataata caaaaatata aattcaacct ctgtatgttt tcttctatgt      180

tttatgctgg gactcactgg agatctttgt aagtaatcaa agctggccct ttatctttga      240

ttttggcttt tagggaattc tagggacttc ctttccccaa attaaaactc attttgaggt      300

gtttggtttt gtcttttaat ttttgcaact tcaaaattga tgactcagtt ctagtgtact      360

ttatcctcga acttgtttaa aataggttac tttcttgaaa taaataataa tataatgaag      420

agatcatgac ttggatttgg gtgggggaat taaatacctt ttcaaaattg ccatcagtat      480

catcttggat gaagaaagtt cagtggttaa aagcgtcttc tgaagtgtgg tcatagtcgg      540

tgaggtttat ttcagtttgg cttctcattt taattttcag atgtatatca catatatgtg      600

aaaagtactg acaaaaataa tttatgaaat aaacacagta gggcatgagg ttgtgttatt      660

tgtgaggcag caatggagca tgacttgtag tcaacaaaca tgggtgtcct gatcaaagct      720

ctgctgtgct attcggcaag actctatgtg gatgcctctt gtagaatgtg gttaataata      780

ccagccgatc tcatagggca ctgtgcagac tcagcattat ggtgcacagc tccttgaact      840

cataggagtg gcacttaact ggagctttgt gtcgtactca tcaaacatct tcccccagac      900

aatgattctt ctgattctgc taactctgga cagagtttgc attgtctttt gagaaaaatg      960

aatgtatcac ttagtcaaaa aactgtaaaa atacataggc tctttccgat gcttgctttc     1020

tcagagccct atgagtttgt ctctctggaa tggctgcaaa agtggttgga tgaatcaaca     1080

cctaccaaac ctattgataa tcacgcttgc ctgtgttccc atgacaagct tcacccggat     1140

aaaatatcaa ttatgaagag gatatctgaa tatgcagctg acattttcta tagtagatat     1200

ggaggaggtc caagactaac tgtgaaagcc ctgtgtaagg aatgtgtagt agaacgttgt     1260

cgcatattgc gtctgaagaa ccaactaaat gaagattata aaactgttaa taatctgctg     1320

aaagcagcag taaagggcga tggattttgg gtggggaagt cctccttgcg gagttggcgc     1380

cagctagctc ttgaacagct ggatgagcaa gatggtgatg cagaacaaag caacggaaag     1440

atgaacggta gcaccttaaa taaagatgaa tcaaaggaag aaagaaaaga agaggaggaa     1500

ttaaatttta atgaagatat tctgtgtcca catggtgagt tatgcatatc tgaaaatgaa     1560

agaaggcttg tttctaaaga ggcttggagc aaactgcagc agtactttcc aaaggctcct     1620

gagtttccaa gttacaaaga gtgctgttca cagtgcaaga ttttagaaag agaaggggaa     1680

gaaaatgaag ccttacataa gatgattgca aacgagcaaa agacttctct cccaaatttg     1740

ttccaggata aaaacagacc gtgtctcagt aactggccag aggatacgga tgtcctctac     1800

atcgtgtctc agttctttgt agaagagtgg cggaaatttg ttagaaagcc tacaagatgc     1860

agccctgtgt catcagttgg gaacagtgct cttttgtgtc cccacggggg cctcatgttt     1920

acatttgctt ccatgaccaa agaagattct aaacttatag ctctcatatg gcccagtgag     1980

tggcaaatga tacaaaagct ctttgttgtg gatcatgtaa ttaaaatcac gagaattgaa     2040

gtgggagatg taaacccttc agaaacacag tatatttctg agcccaaact ctgtccagaa     2100

tgcagagaag gcttattgtg tcagcagcag agggacctgc gtgaatacac tcaagccacc     2160

atctatgtcc ataaagttgt ggataataaa aaggtgatga aggattcggc tccggaactg     2220

aatgtgagta gttctgaaac agaggaggac aaggaagaag ctaaaccaga tggagaaaaa     2280

gatccagatt ttaatcaaat catgcatgca ttttcagttg ctccttttga ccagaatttg     2340

tcaattgatg gaaagatttt aagtgatgac tgtgccaccc taggcaccct tggcgtcatt     2400

cctgaatctg tcattttatt gaaggctgat gaaccaattg cagattatgc tgcaatggat     2460

gatgtcatgc aagtttgtat gccagaagaa gggtttaaag gtactggtct tcttggacat     2520

taatctttga atacttgctg actgctaaga aatgaccaga ggggaagagg agtttgacat     2580

gttagggcat taaagcaaag gtggatttaa gaattaaacc attacatgcc ccttccaaaa     2640

ggcagaaatc cattcaaacg tgactgtccc aaatgcctta tgtcaaataa agcagattgc     2700

actgatggac atcagacttg aaggaaatgt ttccaatttt atatttaagg ggggtggtgg     2760

gtgggagggg gcaagtaaag acggaacaag tttagtagca gtaatagtaa atcatgttta     2820

catatgagat ttatagtcgt gggaggggaa taaagttctg ttatatttcc ttgctcgagt     2880

ttcataccag atgcgttggt ccataaagga ttgtatcaag tagatgggac aacattctgc     2940

tctgaacgaa aagtaatttt agagacataa cctgcttacc aatgcctgtc tttgattcat     3000

attctacttt caataaagca tgaaagtgaa gaacttg                              3037


<210> 1930
<211> 1328
<212> DNA
<213> Homo sapiens

<400> 1930
cggccgcgtt gccaaggtga cccgggcgcg ggaaggcggc tccggctcgc gcgggccggg       60

ccgggcggcg gcggcggcac catgagcggc cggaagcgca gcttcacctt cggggcctac      120

ggcgggtagg gcgtggcgcg gcgcggggcg gggcgcgtgc gcgcgtgtgc gtgtgcacgc      180

gtggggggga gcccgtgcgg ggtgtgctcg cgtttgggcg ggtgggcctg ggctatgact      240

gctgtggggg ctgagcgttt gacctcagtg cgcgcatggc tgtcgtgctg tggcgcctgt      300

gtgtgtgtgt ttctgtttct gtgtctgtgt gtgttcccat tgcgtgtcca tgtgcatgtg      360

tggggaggtg agtgcagggt ggacattgct gtgtttgtgt ctaagcacat gatagtggcg      420

cttatgcatg tgactggggc tgcggggcta ctccgcctgt gtgtgcgcgc gtgtgtgtgc      480

atgcgtgtgt gcgcaactgc tcacatgtat agggtggaca agtccttcac ttctcgccgg      540

agtgtgtgga ggagcgatgg gcagaaccag cacttccctc aggcactaga cctgtcacga      600

gtgaacttag ttccctccta tactccttca ctctacccta agaacacaga tctatttgag      660

atgattgaga agatgcaggg aagcaggatg gatgaacaac gctgctcctt cccgccgccc      720

ctcaaaacag aggaggacta cattccatac ccgagcgtgc acgaggtctt ggggcgagaa      780

ggacccttcc ccctcatcct gctgccccag tttgggggct actggattga gggcaccaac      840

cacgaaatca ccagcatccc cgagacagag ccactgcagt cgcccacaac caaggtgaag      900

ctcgagtgca accccacagc ccgcatctac cggaagcact ttctcggcaa ggagcatttc      960

aattactact cactggacgc tgccctcggc caccttgtct tctcactcaa gtacgatgtc     1020

atcggggacc aagagcacct gcggctgctg ctcaggacca agtgccggac ataccatgat     1080

gtcatcccca tctcctgcct caccgagttc cctaatgttg tccagatggc aaagttggtg     1140

tgtgaagacg tcaatgtgga tcggttctat cctgtgctct accccaaggt atggctggat     1200

ctgggcacag ctcactgagg gtgggtgagt aactggaaga ctgagcattt attaagcacc     1260

ttctgtgtgc cagatacttt cccaaggttc tctcatttaa tcctcacaat aaccctgtga     1320

agtccaca                                                              1328


<210> 1931
<211> 3328
<212> DNA
<213> Homo sapiens

<400> 1931
ctatttgaga tgattgagaa gatgcaggga agcaggatgg atgaacaacg ctgctccttc       60

ccgccgcccc tcaaaacaga ggaggactac attccatacc cgagcgtgca cgaggtcttg      120

gggcgagaag gacccttccc cctcatcctg ctgccccagt ttgggggcta ctggattgag      180

ggcaccaacc acgaaatcac cagcatcccc gagacagagc cactgcagtc gcccacaacc      240

aaggtgaagc tcgagtgcaa ccccacagcc cgcatctacc ggaagcactt tctcggcaag      300

gagcatttca attactactc actggacgct gccctcggcc accttgtctt ctcactcaag      360

tacgatgtca tcggggacca agagcacctg cggctgctgc tcaggaccaa gtgccggaca      420

taccatgatg tcatccccat ctcctgcctc accgagttcc ctaatgttgt ccagatggca      480

aagttggtgt gtgaagacgt caatgtggat cggttctatc ctgtgctcta ccccaaggct      540

tcccggctca tcgtcacctt tgacgagcat gtcatcagca ataacttcaa gtttggcgtc      600

atttatcaga agcttgggca gacctccgag gaagaactct tcagcaccaa tgaggaaagt      660

cccgctttcg tggagttcct tgaatttctt ggccagaagg tcaaactgca ggactttaag      720

gggttccgag gaggcctgga cgtgacccac gggcagacgg ggaccgaatc tgtgtactgc      780

aacttccgca acaaggagat catgtttcac gtgtccacca agctgccata cacggaaggg      840

gacgcccagc agttgcagcg gaagcggcac atcgggaacg acatcgtggc tgtggtcttc      900

caggatgaga acactccttt cgtgcccgac atgatcgcgt ccaacttcct gcatgcctac      960

gtcgtggtgc aggctgaggg cgggggccct gatggccccc tctacaaggt ctctgtcact     1020

gcaagagatg atgtgccctt ctttggaccc cccctcccgg accccgctgt gttcaggaag     1080

gggcctgagt tccaggaatt tttgctgaca aagctgatca atgctgaata tgcctgctac     1140

aaggcagaga agtttgccaa actggaggag cggacgcggg ccgccctcct ggagacgctc     1200

tatgaggaac tacacatcca cagccagtcc atgatgggct tgggcggcga cgaggacaag     1260

atggagaatg gcagtggggg cggcggcttc tttgagtctt tcaagcgggt catccggagc     1320

cgcagccagt ccatggatgc catggggctg agcaacaaga agcccaacac cgtgtccacc     1380

agccacagcg ggagcttcgc gcccaacaac cccgacctgg ccaaggcggc tggaatatca     1440

ttgcttattc ctgggaaaag tgcgagtaga ttcggacgcc ggggcagtgc cataggcata     1500

ggaaccgtgg aagaggttgt cgtccgcggg gccgccggct ctggaggctg cctgcacgcg     1560

ctgttctctg ctcgctctca ggacggaggc catattgggg acgttgcccc tctgcccccg     1620

ggacaggccc cagggcgtgc gggatggagt ggcggcagct ccgatggcac tcagcacctg     1680

ctttggggcc tgtcactgat tgtccctggg aagagcccca cgaggaagaa gtcgggcccg     1740

ttcggctccc gccgcagcag cgccattggc atcgagaaca tacaggaggt gcaggagaag     1800

agggagagcc ctccggctgg tcagaagacc ccagacagcg ggcacgtctc acaggagccc     1860

aagtcggaga actcatccac tcagagctcc ccagagatgc ccacgaccaa gaacagagcg     1920

gagaccgcag cgcagagagc agaggcgctc aagctcccgc tcctcgtcca gtgccagcag     1980

cttcgccagc gtggtggagg agacggaggg tgtggacgga gaggacacag gcctggagag     2040

cgtgtcatcc tcaggaacac cccacaagcg ggactccttc atctatagca cgtggctgga     2100

ggacagtgtc agcaccacta gtgggggcag ctccccaggc ccctctcgat caccccaccc     2160

agacgccggc aagttggggg accctgcgtg tcccgagatc aagatccagc tggaagcatc     2220

tgagcagcac atgccccagc tgggctgtta gccgggccac cccctctgaa ggtgaaactg     2280

agcagatgag gccacagaag cacaagggga aggtgccgtg tcaagcccag gcagacgaga     2340

cctctgccct gaagaccaac accagcccgt gggctgcccc ctgcctcccc accctcccca     2400

tggcccaccc atctgggctg tctctgcagg gcagagccgt ccagacctgg gatcagggaa     2460

gctgctggca tcgtccccac ccccagcctg ggggtctggg ctggggcagg gattgctcag     2520

tggaagcagg actgggggtc tggcttgccc cctccctggg cctccatcac ccctgagcat     2580

ccctctggac tcagagggaa caaggtggga gagagagttt gagacagctc cgtgtggaga     2640

gcttagcccc tggaggcagc acaaggagga tgtgatatgt gggggagtga gcactgggtt     2700

gggagccggg tcctggtttc caatttgggt tctgctgtgt gactctgggc aagtcactct     2760

ccctctctgg gcatgtctgc tacaaatgga caagattatt tcagaggtca ctgaagactg     2820

tgattacatg cacctgcctt agaaggtagg attttcttcc cagggacctc ctatcaccct     2880

accctgcttc ttgaggtccc tggagcccca ggtgggctga ggggcaggga gccggctgtg     2940

cccagtatgc ctcctggacc ctccagttct gccacaggtc tgccgatgcc ctgtccactg     3000

cctacacatg acagacaagt aaccccctca tgggggatgg ggacctacct ggctcctcag     3060

ccagcaccca gcttaacccc tgccatccca tgctgggccc tccaggccaa gagtctcagc     3120

tggccgagag tccaggcctt gcctcccccg accgccatgg agggggcagc ccggcacagc     3180

tgctgggagc ccttgtgtgt ctggtcacac tttttaggcg tcacgccaaa ggccagcctc     3240

ctggccccaa tacccatttt ggaagcccct gtggccgtgt ggatgtcggt aacagttgta     3300

taaaataaat tctatttatc gctattgt                                        3328


<210> 1932
<211> 3169
<212> DNA
<213> Homo sapiens

<400> 1932
atggcacagc tgcggcccgc ggtgccaccc ggccgtccgc ggaggggctc gctgcccgcg       60

ggggccagct ggcagaacac agatctattt gagatgattg agaagatgca gggaagcagg      120

atggatgaac aacgctgctc cttcccgccg cccctcaaaa cagaggagga ctacattcca      180

tacccgagcg tgcacgaggt cttggggcga gaaggaccct tccccctcat cctgctgccc      240

cagtttgggg gctactggat tgagggcacc aaccacgaaa tcaccagcat ccccgagaca      300

gagccactgc agtcgcccac aaccaaggtg aagctcgagt gcaaccccac agcccgcatc      360

taccggaagc actttctcgg caaggagcat ttcaattact actcactgga cgctgccctc      420

ggccaccttg tcttctcact caagtacgat gtcatcgggg accaagagca cctgcggctg      480

ctgctcagga ccaagtgccg gacataccat gatgtcatcc ccatctcctg cctcaccgag      540

ttccctaatg ttgtccagat ggcaaagttg gtgtgtgaag acgtcaatgt ggatcggttc      600

tatcctgtgc tctaccccaa ggcttcccgg ctcatcgtca cctttgacga gcatgtcatc      660

agcaataact tcaagtttgg cgtcatttat cagaagcttg ggcagacctc cgaggaagaa      720

ctcttcagca ccaatgagga aagtcccgct ttcgtggagt tccttgaatt tcttggccag      780

aaggtcaaac tgcaggactt taaggggttc cgaggaggcc tggacgtgac ccacgggcag      840

acggggaccg aatctgtgta ctgcaacttc cgcaacaagg agatcatgtt tcacgtgtcc      900

accaagctgc catacacgga aggggacgcc cagcagttgc agcggaagcg gcacatcggg      960

aacgacatcg tggctgtggt cttccaggat gagaacactc ctttcgtgcc cgacatgatc     1020

gcgtccaact tcctgcatgc ctacgtcgtg gtgcaggctg agggcggggg ccctgatggc     1080

cccctctaca aggtctctgt cactgcaaga gatgatgtgc ccttctttgg accccccctc     1140

ccggaccccg ctgtgttcag gaaggggcct gagttccagg aatttttgct gacaaagctg     1200

atcaatgctg aatatgcctg ctacaaggca gagaagtttg ccaaactgga ggagcggacg     1260

cgggccgccc tcctggagac gctctatgag gaactacaca tccacagcca gtccatgatg     1320

ggcttgggcg gcgacgagga caagatggag aatggcagtg ggggcggcgg cttctttgag     1380

tctttcaagc gggtcatccg gagccgcagc cagtccatgg atgccatggg gctgagcaac     1440

aagaagccca acaccgtgtc caccagccac agcgggagct tcgcgcccaa caaccccgac     1500

ctggccaagg cggctggaat atcactgatt gtccctggga agagccccac gaggaagaag     1560

tcgggcccgt tcggctcccg ccgcagcagc gccattggca tcgagaacat acaggaggtg     1620

caggagaaga gggagagccc tccggctggt cagaagaccc cagacagcgg gcacgtctca     1680

caggagccca agtcggagaa ctcatccact cagagctccc cagagatgcc cacgaccaag     1740

aacagagcgg agaccgcagc gcagagagca gaggcgctca aggacttctc ccgctcctcg     1800

tccagtgcca gcagcttcgc cagcgtggtg gaggagacgg agggtgtgga cggagaggac     1860

acaggcctgg agagcgtgtc atcctcagga acaccccaca agcgggactc cttcatctat     1920

agcacgtggc tggaggacag tgtcagcacc actagtgggg gcagctcccc aggcccctct     1980

cgatcacccc acccagacgc cggcaagttg ggggaccctg cgtgtcccga gatcaagatc     2040

cagctggaag catctgagca gcacatgccc cagctgggct gttagccggg ccaccccctc     2100

tgaaggtgaa actgagcaga tgaggccaca gaagcacaag gggaaggtgc cgtgtcaagc     2160

ccaggcagac gagacctctg ccctgaagac caacaccagc ccgtgggctg ccccctgcct     2220

ccccaccctc cccatggccc acccatctgg gctgtctctg cagggcagag ccgtccagac     2280

ctgggatcag ggaagctgct ggcatcgtcc ccacccccag cctgggggtc tgggctgggg     2340

cagggattgc tcagtggaag caggactggg ggtctggctt gccccctccc tgggcctcca     2400

tcacccctga gcatccctct ggactcagag ggaacaaggt gggagagaga gtttgagaca     2460

gctccgtgtg gagagcttag cccctggagg cagcacaagg aggatgtgat atgtggggga     2520

gtgagcactg ggttgggagc cgggtcctgg tttccaattt gggttctgct gtgtgactct     2580

gggcaagtca ctctccctct ctgggcatgt ctgctacaaa tggacaagat tatttcagag     2640

gtcactgaag actgtgatta catgcacctg ccttagaagg taggattttc ttcccaggga     2700

cctcctatca ccctaccctg cttcttgagg tccctggagc cccaggtggg ctgaggggca     2760

gggagccggc tgtgcccagt atgcctcctg gaccctccag ttctgccaca ggtctgccga     2820

tgccctgtcc actgcctaca catgacagac aagtaacccc ctcatggggg atggggacct     2880

acctggctcc tcagccagca cccagcttaa cccctgccat cccatgctgg gccctccagg     2940

ccaagagtct cagctggccg agagtccagg ccttgcctcc cccgaccgcc atggaggggg     3000

cagcccggca cagctgctgg gagcccttgt gtgtctggtc acacttttta ggcgtcacgc     3060

caaaggccag cctcctggcc ccaataccca ttttggaagc ccctgtggcc gtgtggatgt     3120

cggtaacagt tgtataaaat aaattctatt tatcgctatt gtacccaga                 3169


<210> 1933
<211> 3264
<212> DNA
<213> Homo sapiens

<400> 1933
ggagctcagc gctgcggggc ccggacccgg gcgcgcgcgg gccaggagcc ggctgggcca       60

gctgaagtgc cgccccggcg ggggccgggc cgggccgcgc tcaggatggc acagctgcgg      120

cccgcggtgc cacccggccg tccgcggagg ggctcgctgc ccgcgggggc cagctggcag      180

aacacagatc tatttgagat gattgagaag atgcagggaa gcaggatgga tgaacaacgc      240

tgctccttcc cgccgcccct caaaacagag gaggactaca ttccataccc gagcgtgcac      300

gaggtcttgg ggcgagaagg acccttcccc ctcatcctgc tgccccagtt tgggggctac      360

tggattgagg gcaccaacca cgaaatcacc agcatccccg agacagagcc actgcagtcg      420

cccacaacca aggtgaagct cgagtgcaac cccacagccc gcatctaccg gaagcacttt      480

ctcggcaagg agcatttcaa ttactactca ctggacgctg ccctcggcca ccttgtcttc      540

tcactcaagt acgatgtcat cggggaccaa gagcacctgc ggctgctgct caggaccaag      600

tgccggacat accatgatgt catccccatc tcctgcctca ccgagttccc taatgttgtc      660

cagatggcaa agttggtgtg tgaagacgtc aatgtggatc ggttctatcc tgtgctctac      720

cccaaggctt cccggctcat cgtcaccttt gacgagcatg tcatcagcaa taacttcaag      780

tttggcgtca tttatcagaa gcttgggcag acctccgagg aagaactctt cagcaccaat      840

gaggaaagtc ccgctttcgt ggagttcctt gaatttcttg gccagaaggt caaactgcag      900

gactttaagg ggttccgagg aggcctggac gtgacccacg ggcagacggg gaccgaatct      960

gtgtactgca acttccgcaa caaggagatc atgtttcacg tgtccaccaa gctgccatac     1020

acggaagggg acgcccagtt gcagcggaag cggcacatcg ggaacgacat cgtggctgtg     1080

gtcttccagg atgagaacac tcctttcgtg cccgacatga tcgcgtccaa cttcctgcat     1140

gcctacgtcg tggtgcaggc tgagggcggg ggccctgatg gccccctcta caaggtctct     1200

gtcactgcaa gagatgatgt gcccttcttt ggaccccccc tcccggaccc cgctgtgttc     1260

aggaaggggc ctgagttcca ggaatttttg ctgacaaagc tgatcaatgc tgaatatgcc     1320

tgctacaagg cagagaagtt tgccaaactg gaggagcgga cgcgggccgc cctcctggag     1380

acgctctatg aggaactaca catccacagc cagtccatga tgggcttggg cggcgacgag     1440

gacaagatgg agaatggcag tgggggcggc ggcttctttg agtctttcaa gcgggtcatc     1500

cggagccgca gccagtccat ggatgccatg gggctgagca acaagaagcc caacaccgtg     1560

tccaccagcc acagcgggag cttcgcgccc aacaaccccg acctggccaa ggcggctgga     1620

atatcactga ttgtccctgg gaagagcccc acgaggaaga agtcgggccc gttcggctcc     1680

cgccgcagca gcgccattgg catcgagaac atacaggagg tgcaggagaa gagggagagc     1740

cctccggctg gtcagaagac cccagacagc gggcacgtct cacaggagcc caagtcggag     1800

aactcatcca ctcagagctc cccagagatg cccacgacca agaacagagc ggagaccgca     1860

gcgcagagag cagaggcgct caaggacttc tcccgctcct cgtccagtgc cagcagcttc     1920

gccagcgtgg tggaggagac ggagggtgtg gacggagagg acacaggcct ggagagcgtg     1980

tcatcctcag gaacacccca caagcgggac tccttcatct atagcacgtg gctggaggac     2040

agtgtcagca ccactagtgg gggcagctcc ccaggcccct ctcgatcacc ccacccagac     2100

gccggcaagt tgggggaccc tgcgtgtccc gagatcaaga tccagctgga agcatctgag     2160

cagcacatgc cccagctggg ctgttagccg ggccaccccc tctgaaggtg aaactgagca     2220

gatgaggcca cagaagcaca aggggaaggt gccgtgtcaa gcccaggcag acgagacctc     2280

tgccctgaag accaacacca gcccgtgggc tgccccctgc ctccccaccc tccccatggc     2340

ccacccatct gggctgtctc tgcagggcag agccgtccag acctgggatc agggaagctg     2400

ctggcatcgt ccccaccccc agcctggggg tctgggctgg ggcagggatt gctcagtgga     2460

agcaggactg ggggtctggc ttgccccctc cctgggcctc catcacccct gagcatccct     2520

ctggactcag agggaacaag gtgggagaga gagtttgaga cagctccgtg tggagagctt     2580

agcccctgga ggcagcacaa ggaggatgtg atatgtgggg gagtgagcac tgggttggga     2640

gccgggtcct ggtttccaat ttgggttctg ctgtgtgact ctgggcaagt cactctccct     2700

ctctgggcat gtctgctaca aatggacaag attatttcag aggtcactga agactgtgat     2760

tacatgcacc tgccttagaa ggtaggattt tcttcccagg gacctcctat caccctaccc     2820

tgcttcttga ggtccctgga gccccaggtg ggctgagggg cagggagccg gctgtgccca     2880

gtatgcctcc tggaccctcc agttctgcca caggtctgcc gatgccctgt ccactgccta     2940

cacatgacag acaagtaacc ccctcatggg ggatggggac ctacctggct cctcagccag     3000

cacccagctt aacccctgcc atcccatgct gggccctcca ggccaagagt ctcagctggc     3060

cgagagtcca ggccttgcct cccccgaccg ccatggaggg ggcagcccgg cacagctgct     3120

gggagccctt gtgtgtctgg tcacactttt taggcgtcac gccaaaggcc agcctcctgg     3180

ccccaatacc cattttggaa gcccctgtgg ccgtgtggat gtcggtaaca gttgtataaa     3240

ataaattcta tttatcgcta ttgt                                            3264


<210> 1934
<211> 3271
<212> DNA
<213> Homo sapiens

<400> 1934
ggccgcgggc accagagtgc cgagcccagg acgcccccgg cccaggccct tggggtggac       60

aagtccttca cttctcgccg gagtgtgtgg aggagcgatg ggcagaacca gcacttccct      120

caggcactag acctgtcacg agtgaactta gttccctcct atactccttc actctaccct      180

aagaacacag atctatttga gatgattgag aagatgcagg gaagcaggat ggatgaacaa      240

cgctgctcct tcccgccgcc cctcaaaaca gaggaggact acattccata cccgagcgtg      300

cacgaggtct tggggcgaga aggacccttc cccctcatcc tgctgcccca gtttgggggc      360

tactggattg agggcaccaa ccacgaaatc accagcatcc ccgagacaga gccactgcag      420

tcgcccacaa ccaaggtgaa gctcgagtgc aaccccacag cccgcatcta ccggaagcac      480

tttctcggca aggagcattt caattactac tcactggacg ctgccctcgg ccaccttgtc      540

ttctcactca agtacgatgt catcggggac caagagcacc tgcggctgct gctcaggacc      600

aagtgccgga cataccatga tgtcatcccc atctcctgcc tcaccgagtt ccctaatgtt      660

gtccagatgg caaagttggt gtgtgaagac gtcaatgtgg atcggttcta tcctgtgctc      720

taccccaagg cttcccggct catcgtcacc tttgacgagc atgtcatcag caataacttc      780

aagtttggcg tcatttatca gaagcttggg cagacctccg aggaagaact cttcagcacc      840

aatgaggaaa gtcccgcttt cgtggagttc cttgaatttc ttggccagaa ggtcaaactg      900

caggacttta aggggttccg aggaggcctg gacgtgaccc acgggcagac ggggaccgaa      960

tctgtgtact gcaacttccg caacaaggag atcatgtttc acgtgtccac caagctgcca     1020

tacacggaag gggacgccca gcagttgcag cggaagcggc acatcgggaa cgacatcgtg     1080

gctgtggtct tccaggatga gaacactcct ttcgtgcccg acatgatcgc gtccaacttc     1140

ctgcatgcct acgtcgtggt gcaggctgag ggcgggggcc ctgatggccc cctctacaag     1200

gtctctgtca ctgcaagaga tgatgtgccc ttctttggac cccccctccc ggaccccgct     1260

gtgttcagga aggggcctga gttccaggaa tttttgctga caaagctgat caatgctgaa     1320

tatgcctgct acaaggcaga gaagtttgcc aaactggagg agcggacgcg ggccgccctc     1380

ctggagacgc tctatgagga actacacatc cacagccagt ccatgatggg cttgggcggc     1440

gacgaggaca agatggagaa tggcagtggg ggcggcggct tctttgagtc tttcaagcgg     1500

gtcatccgga gccgcagcca gtccatggat gccatggggc tgagcaacaa gaagcccaac     1560

accgtgtcca ccagccacag cgggagcttc gcgcccaaca accccgacct ggccaaggcg     1620

gctggaatat cactgattgt ccctgggaag agccccacga ggaagaagtc gggcccgttc     1680

ggctcccgcc gcagcagcgc cattggcatc gagaacatac aggaggtgca ggagaagagg     1740

gagagccctc cggctggtca gaagacccca gacagcgggc acgtctcaca ggagcccaag     1800

tcggagaact catccactca gagctcccca gagatgccca cgaccaagaa cagagcggag     1860

accgcagcgc agagagcaga ggcgctcaag gacttctccc gctcctcgtc cagtgccagc     1920

agcttcgcca gcgtggtgga ggagacggag ggtgtggacg gagaggacac aggcctggag     1980

agcgtgtcat cctcaggaac accccacaag cgggactcct tcatctatag cacgtggctg     2040

gaggacagtg tcagcaccac tagtgggggc agctccccag gcccctctcg atcaccccac     2100

ccagacgccg gcaagttggg ggaccctgcg tgtcccgaga tcaagatcca gctggaagca     2160

tctgagcagc acatgcccca gctgggctgt tagccgggcc accccctctg aaggtgaaac     2220

tgagcagatg aggccacaga agcacaaggg gaaggtgccg tgtcaagccc aggcagacga     2280

gacctctgcc ctgaagacca acaccagccc gtgggctgcc ccctgcctcc ccaccctccc     2340

catggcccac ccatctgggc tgtctctgca gggcagagcc gtccagacct gggatcaggg     2400

aagctgctgg catcgtcccc acccccagcc tgggggtctg ggctggggca gggattgctc     2460

agtggaagca ggactggggg tctggcttgc cccctccctg ggcctccatc acccctgagc     2520

atccctctgg actcagaggg aacaaggtgg gagagagagt ttgagacagc tccgtgtgga     2580

gagcttagcc cctggaggca gcacaaggag gatgtgatat gtgggggagt gagcactggg     2640

ttgggagccg ggtcctggtt tccaatttgg gttctgctgt gtgactctgg gcaagtcact     2700

ctccctctct gggcatgtct gctacaaatg gacaagatta tttcagaggt cactgaagac     2760

tgtgattaca tgcacctgcc ttagaaggta ggattttctt cccagggacc tcctatcacc     2820

ctaccctgct tcttgaggtc cctggagccc caggtgggct gaggggcagg gagccggctg     2880

tgcccagtat gcctcctgga ccctccagtt ctgccacagg tctgccgatg ccctgtccac     2940

tgcctacaca tgacagacaa gtaaccccct catgggggat ggggacctac ctggctcctc     3000

agccagcacc cagcttaacc cctgccatcc catgctgggc cctccaggcc aagagtctca     3060

gctggccgag agtccaggcc ttgcctcccc cgaccgccat ggagggggca gcccggcaca     3120

gctgctggga gcccttgtgt gtctggtcac actttttagg cgtcacgcca aaggccagcc     3180

tcctggcccc aatacccatt ttggaagccc ctgtggccgt gtggatgtcg gtaacagttg     3240

tataaaataa attctattta tcgctattgt a                                    3271


<210> 1935
<211> 1633
<212> DNA
<213> Homo sapiens

<400> 1935
gcgtctgcca atgatccagg agccgctcct ttccactcgg gaaaccttca gaggagtctc       60

agaaaggaca cggctggctg cttttctcag cgccgaagcc gcgccatgct cgtcctcaga      120

agcgccctga ctcgggcgct ggcctcacgg acgctggcgc ctcagatgtg ctcatctttt      180

gctacgggac ccagacaata cgatggaata ttctatgaat ttcgttctta ttaccttaag      240

ccctcaaaga tgaatgagtt cctggaaaat tttgagaaaa acgctcatct tcggacagct      300

cactctgaat tggttggata ctggagtgta gaatttggag gcagaatgaa tacagtgttt      360

catatttgga agtatgataa ttttgctcat cgaactgaag ttcggaaagc cttggccaaa      420

gataaggaat ggcaagaaca attcctcatt ccaaatttgg ctctcattga taaacaagag      480

agtgagatta cttatctggt accatggtgc aaattagaaa aacctccaaa agaaggagtc      540

tatgaactgg ccacttttca gatgaaacct ggtgggccag ctctgtgggg tgatgcattt      600

aaaagggcag ttcatgctca tgtcaatcta ggctacacaa aactagttgg agtgttccac      660

acagagtacg gagcactcaa cagagttcat gttctttggt ggaatgagag tgcagatagt      720

cgtgcagctg ggagacataa gtcccatgag gatcccagag ttgtggcagc tgttcgggaa      780

agtgtcaact acctagtatc tcagcagaat atgcttctga ttcctacatc gttttcacca      840

ctgaaatagt tttctactga aatacaaaac atttcattaa ctgctatagg atctgtctgc      900

taatggtgct taaattctcc caagaggttc tcacttttat ttgaaggagg tgttaagtta      960

atttgctatg tttcttgcat tatgaaggct acatctgtgc tttgtaagta ccacttcaaa     1020

aaatagttct gtttactttc tgcatggtat ttcagtgtct gtcatacatt aaaaatactt     1080

gtcactgttt taagatcttg actcttcatt tgtttcagaa tagctcttct actgtattct     1140

gacaactctt tgctttatag cattttgttg tattcaaatg ataatggtag catttccatg     1200

cttgtgacag catttttaag ttattaatat attttatcaa cctttccatc atgtctgttt     1260

tcctggtttt ttttggttgt tttttgacca gtaaaattta ttttgtaata ccaaatagga     1320

tttaagaaaa ttaacgtatt tctttactat ggaaaaccac attgtcattt gtgacatcat     1380

ctatattaaa tatggttttc acattagtta tttgtcactt acttggaaaa tgatgctgtt     1440

aggtcctggt attaaaaatc tagaaaagac ttgttggttt atgtgctgaa atgtctttat     1500

ttataattaa ttttaactac tatttacttc atttcggatc ctgtttaaca aagatacttg     1560

agacatccat ttgttttaat gaaatctgta tggatatgga aatgcttgcc ctaataaaag     1620

cctacatata cct                                                        1633


<210> 1936
<211> 4266
<212> DNA
<213> Homo sapiens

<400> 1936
gggggctgta gggaggggga ccagtggcag agggacctta ggtgatcctt agaaataaag       60

gctagcttct gttcgacctt ggagtagggc gaagaggtgt agacaggcct ggagaagcga      120

ggtaaaagcc tgagtaaaag caagaagttg gagaatatga gatacatctc atctctagta      180

aatacttaaa tgacttcccc tcctcccgga gtcaagcaca attcggggat gcaatgacgg      240

acgtaggtga agacactgcg ggaacttaca gacaaaactg gtttgtggcc tgtttgattc      300

ctgtcagagg tttgctgacc caagacagta tcgaaaatgc atattaagtc aattattcta      360

gagggattca agtcctatgc tcagaggacc gaagtcaatg gttttgaccc cctcttcaat      420

gctatcactg gcttaaatgg tagtgggaaa tccaacatat tggactccat ctgctttttg      480

ctgggcatct ccaacctgtc tcaggttcgg gcttctaatt tacaagattt agtttacaaa      540

aatgggcagg ctggtattac caaagcctct gtgtcaatca cttttgataa ttctgacaaa      600

aagcaaagtc ctttaggatt tgaggttcat gatgaaatca cagtaacaag gcaggtggtt      660

attggtggta gaaataaata tttaatcaat ggagtcaatg ccaacaacac cagagtacag      720

gatctcttct gttctgttgg ccttaatgtt aacaaccctc actttctcat catgcagggc      780

cgaattacaa aagtattgaa tatgaaacct ccagagattt tatccatgat agaagaagca      840

gctggaacca ggatgtatga atacaaaaaa atagctgcac agaaaactat agaaaaaaag      900

gaggctaagc tgaaagaaat taagacgata cttgaagaag agattactcc aaccattcaa      960

aaattaaaag aggaaagatc gtcctacttg gagtaccaaa aagtaatgag agaaatagaa     1020

catttgagtc gtttatatat tgcttatcag tttttgctgg ctgaagatac caaagtacgc     1080

tcagctgagg aattaaaaga aatgcaagat aaagttataa agcttcagga agaattgtct     1140

gagaatgata aaaaaataaa agcacttaat catgaaatag aagaattgga aaaaagaaaa     1200

gataaggaaa ctggaggtat acttcgatct ttagaagatg ctcttgcaga ggctcagcga     1260

gttaatacta aatctcaaag cgcatttgat ctcaagaaga aaaatctggc atgtgaggaa     1320

agcaaacgca aagagctgga aaaaaatatg gttgaggact caaaaacttt agcagcaaag     1380

gaaaaagagg ttaaaaagat aacagatgga ctgcatgccc ttcaagaagc aagtaataaa     1440

gatgctgaag ctctggcagc tgcacagcag cacttcaatg ctgtttccgc tggcctgtcc     1500

agtaatgaag atggagcaga agcaactctt gctggtcaaa tgatggcctg taaaaatgat     1560

ataagtaaag ctcagacaga agccaaacag gctcagatga agttgaagca tgctcaacag     1620

gaattaaaga ataaacaagc tgaagttaag aagatggata gtggctacag gaaggatcaa     1680

gaagctctag aagctgtaaa aagacttaaa gaaaaacttg aagctgaaat gaaaaagcta     1740

aattatgaag aaaataaaga ggaaagcctt ttggaaaagc gcaggcagct gtctcgtgat     1800

attggtagat tgaaagaaac atatgaagct ctattagcca gatttcccaa tcttcgattt     1860

gcatacaagg atccagagaa gaactggaat agaaattgtg tgaaaggact tgtggcttct     1920

ctgattagtg tgaaagacac ttctgcaacc acagctttag aattagtggc tggagaacga     1980

ctctacaatg ttgtagtaga cacagaagtt actggtaaaa agctactaga aaggggggaa     2040

ctgaaacgtc gatacactat aattccactc aataaaattt cagccagatg tattgcacca     2100

gaaactctga gagttgctca gaatcttgtt ggccctgaca acgttcatgt ggctctttcc     2160

ttggttgaat ataaaccaga acttcagaaa gcaatggagt ttgtctttgg aacaacattt     2220

gtttgtgaca atatggataa tgccaaaaaa gtggcctttg ataagaggat aatgactaga     2280

actgtaactc tcggaggtga tgtgtttgat cctcatggga cattgagtgg aggtgctcga     2340

tcccaggcag cttccatttt aaccaagttt caagaactca aagatgttca ggatgaactg     2400

agaatcaaag agaatgagct gcgggctcta gaagaggaat tagcaggtct taaaaacact     2460

gctgaaaagt atcgccaact aaaacagcag tgggagatga aaactgaaga ggcagattta     2520

ttacaaacca agctccagca aagctcatat cacaagcaac aagaagaatt agatgccctt     2580

aaaaaaacca ttgaggaaag tgaggagact ttgaaaaaca ctaaagaaat ccaaagaaaa     2640

gcagaagaaa aatatgaagt attggaaaat aaaatgaaaa atgcagaagc tgaaagagag     2700

cgagaactga aagatgctca gaaaaaactg gattgtgcca aaacaaaggc agatgcatct     2760

agcaagaaga tgaaagaaaa acaacaggaa gttgaagcta tcactctgga actggaagag     2820

ctcaagagag agcatacatc ttacaaacaa cagcttgaag ctgtaaatga agctatcaaa     2880

tcctatgaaa gtcagattga agtaatggca gctgaggtgg ctaaaaataa ggagtcagta     2940

aataaagctc aagaagaggt gaccaagcaa aaagaggtga taacagccca agacactgta     3000

attaaagcta aatatgcaga agtggcaaaa cacaaggagc aaaacaatga ttctcagctt     3060

aaaattaagg aattagacca caacatcagc aaacataaac gggaggctga agatggtgct     3120

gcaaaggtat ccaaaatgtt gaaagattat gactggatta atgcagagag acacctcttt     3180

ggccaaccca atagtgccta tgatttcaaa actaacaacc ctaaagaagc tggtcagaga     3240

cttcagaagt tgcaagaaat gaaggagaaa ctaggaagaa atgtcaatat gagagctatg     3300

aatgtattga cagaagctga agagcgatac aatgacttga tgaagaagaa gagaattgta     3360

gaaaatgaca aatccaaaat tcttacaact atagaagacc ttgaccagaa gaaaaaccaa     3420

gccctaaata ttgcatggca aaaggtgaac aaggactttg ggtctatttt ttctactctt     3480

ttgcctggtg ctaatgctat gcttgcacca ccagagggtc aaactgtttt ggatggtctg     3540

gagttcaagg ttgccttggg aaatacctgg aaagaaaacc taactgaact tagtggtggt     3600

cagaggtctt tagtggcctt gtcattaata ctgtccatgc ttctcttcaa acctgctcca     3660

atttatatcc ttgatgaggt agatgcagcc ttggatcttt ctcataccca aaacattgga     3720

cagatgctgc gtactcattt cacacattct cagttcattg tggtgtcact aaaagaaggt     3780

atgttcaaca atgcaaacgt tcttttcaaa accaagtttg tggatggtgt ttctacagta     3840

gccagattta ctcaatgtca aaatggaaag atttcaaagg aagcaaaatc caaggcaaaa     3900

ccacccaaag gagcacatgt ggaagtttaa actacaaagt tatttcttca tcttgacctg     3960

tttttttaaa tgtaaacttt taaggacttg agataactaa tttgtttata tacaaaaatt     4020

aatgttactg tgttacttaa cccatgtttt ctctttatat aatcacttat cgcttacaaa     4080

tgagcatata ttcctcatct cttaactagt ctaattatgg tccaattatt gtggttgtga     4140

ttttatgcat atcatcaaat gtttttttct tatgcgggtc ttttatatat tagggatcct     4200

gagatacccg attctatatg taaaagctaa tatacaaaaa agcagattaa attacatgat     4260

aaatgt                                                                4266


<210> 1937
<211> 5909
<212> DNA
<213> Homo sapiens

<400> 1937
cggcgcgggt gttgagagcg gtgtggcagg tgttgtagcc gctatggtga agttcgcttt       60

gtagcggccc cggctagaga gttgttctgt tccctgcctt tgtgacccgg aggagctttt      120

ggggtgcgtc aagcccctgg cctgaggcag cgaactggtt tgtggcctgt ttgattcctg      180

tcagaggttt gctgacccaa gacagtatcg aaaatgcata ttaagtcaat tattctagag      240

ggattcaagt cctatgctca gaggaccgaa gtcaatggtt ttgaccccct cttcaatgct      300

atcactggct taaatggtag tgggaaatcc aacatattgg actccatctg ctttttgctg      360

ggcatctcca acctgtctca ggttcgggct tctaatttac aagatttagt ttacaaaaat      420

gggcaggctg gtattaccaa agcctctgtg tcaatcactt ttgataattc tgacaaaaag      480

caaagtcctt taggatttga ggttcatgat gaaatcacag taacaaggca ggtggttatt      540

ggtggtagaa ataaatattt aatcaatgga gtcaatgcca acaacaccag agtacaggat      600

ctcttctgtt ctgttggcct taatgttaac aaccctcact ttctcatcat gcagggccga      660

attacaaaag tattgaatat gaaacctcca gagattttat ccatgataga agaagcagct      720

ggaaccagga tgtatgaata caaaaaaata gctgcacaga aaactataga aaaaaaggag      780

gctaagctga aagaaattaa gacgatactt gaagaagaga ttactccaac cattcaaaaa      840

ttaaaagagg aaagatcgtc ctacttggag taccaaaaag taatgagaga aatagaacat      900

ttgagtcgtt tatatattgc ttatcagttt ttgctggctg aagataccaa agtacgctca      960

gctgaggaat taaaagaaat gcaagataaa gttataaagc ttcaggaaga attgtctgag     1020

aatgataaaa aaataaaagc acttaatcat gaaatagaag aattggaaaa aagaaaagat     1080

aaggaaactg gaggtatact tcgatcttta gaagatgctc ttgcagaggc tcagcgagtt     1140

aatactaaat ctcaaagcgc atttgatctc aagaagaaaa atctggcatg tgaggaaagc     1200

aaacgcaaag agctggaaaa aaatatggtt gaggactcaa aaactttagc agcaaaggaa     1260

aaagaggtta aaaagataac agatggactg catgcccttc aagaagcaag taataaagat     1320

gctgaagctc tggcagctgc acagcagcac ttcaatgctg tttccgctgg cctgtccagt     1380

aatgaagatg gagcagaagc aactcttgct ggtcaaatga tggcctgtaa aaatgatata     1440

agtaaagctc agacagaagc caaacaggct cagatgaagt tgaagcatgc tcaacaggaa     1500

ttaaagaata aacaagctga agttaagaag atggatagtg gctacaggaa ggatcaagaa     1560

gctctagaag ctgtaaaaag acttaaagaa aaacttgaag ctgaaatgaa aaagctaaat     1620

tatgaagaaa ataaagagga aagccttttg gaaaagcgca ggcagctgtc tcgtgatatt     1680

ggtagattga aagaaacata tgaagctcta ttagccagat ttcccaatct tcgatttgca     1740

tacaaggatc cagagaagaa ctggaataga aattgtgtga aaggacttgt ggcttctctg     1800

attagtgtga aagacacttc tgcaaccaca gctttagaat tagtggctgg agaacgactc     1860

tacaatgttg tagtagacac agaagttact ggtaaaaagc tactagaaag gggggaactg     1920

aaacgtcgat acactataat tccactcaat aaaatttcag ccagatgtat tgcaccagaa     1980

actctgagag ttgctcagaa tcttgttggc cctgacaacg ttcatgtggc tctttccttg     2040

gttgaatata aaccagaact tcagaaagca atggagtttg tctttggaac aacatttgtt     2100

tgtgacaata tggataatgc caaaaaagtg gcctttgata agaggataat gactagaact     2160

gtaactctcg gaggtgatgt gtttgatcct catgggacat tgagtggagg tgctcgatcc     2220

caggcagctt ccattttaac caagtttcaa gaactcaaag atgttcagga tgaactgaga     2280

atcaaagaga atgagctgcg ggctctagaa gaggaattag caggtcttaa aaacactgct     2340

gaaaagtatc gccaactaaa acagcagtgg gagatgaaaa ctgaagaggc agatttatta     2400

caaaccaagc tccagcaaag ctcatatcac aagcaacaag aagaattaga tgcccttaaa     2460

aaaaccattg aggaaagtga ggagactttg aaaaacacta aagaaatcca aagaaaagca     2520

gaagaaaaat atgaagtatt ggaaaataaa atgaaaaatg cagaagctga aagagagcga     2580

gaactgaaag atgctcagaa aaaactggat tgtgccaaaa caaaggcaga tgcatctagc     2640

aagaagatga aagaaaaaca acaggaagtt gaagctatca ctctggaact ggaagagctc     2700

aagagagagc atacatctta caaacaacag cttgaagctg taaatgaagc tatcaaatcc     2760

tatgaaagtc agattgaagt aatggcagct gaggtggcta aaaataagga gtcagtaaat     2820

aaagctcaag aagaggtgac caagcaaaaa gaggtgataa cagcccaaga cactgtaatt     2880

aaagctaaat atgcagaagt ggcaaaacac aaggagcaaa acaatgattc tcagcttaaa     2940

attaaggaat tagaccacaa catcagcaaa cataaacggg aggctgaaga tggtgctgca     3000

aaggtatcca aaatgttgaa agattatgac tggattaatg cagagagaca cctctttggc     3060

caacccaata gtgcctatga tttcaaaact aacaacccta aagaagctgg tcagagactt     3120

cagaagttgc aagaaatgaa ggagaaacta ggaagaaatg tcaatatgag agctatgaat     3180

gtattgacag aagctgaaga gcgatacaat gacttgatga agaagaagag aattgtagaa     3240

aatgacaaat ccaaaattct tacaactata gaagaccttg accagaagaa aaaccaagcc     3300

ctaaatattg catggcaaaa ggtgaacaag gactttgggt ctattttttc tactcttttg     3360

cctggtgcta atgctatgct tgcaccacca gagggtcaaa ctgttttgga tggtctggag     3420

ttcaaggttg ccttgggaaa tacctggaaa gaaaacctaa ctgaacttag tggtggtcag     3480

aggtctttag tggccttgtc attaatactg tccatgcttc tcttcaaacc tgctccaatt     3540

tatatccttg atgaggtaga tgcagccttg gatctttctc atacccaaaa cattggacag     3600

atgctgcgta ctcatttcac acattctcag ttcattgtgg tgtcactaaa agaaggtatg     3660

ttcaacaatg caaacgttct tttcaaaacc aagtttgtgg atggtgtttc tacagtagcc     3720

agatttactc aatgtcaaaa tggaaagatt tcaaaggaag caaaatccaa ggcaaaacca     3780

cccaaaggag cacatgtgga agtttaaact acaaagttat ttcttcatct tgacctgttt     3840

ttttaaatgt aaacttttaa ggacttgaga taactaattt gtttatatac aaaaattaat     3900

gttactgtgt tacttaaccc atgttttctc tttatataat cacttatcgc ttacaaatga     3960

gcatatattc ctcatctctt aactagtcta attatggtcc aattattgtg gttgtgattt     4020

tatgcatatc atcaaatgtt tttttcttat gcgggtcttt tatatattag ggatcctgag     4080

atacccgatt ctatatgtaa aagctaatat acaaaaaagc agattaaatt acatgataaa     4140

tgtagctgat catcagtgtt taattgattt aattcctaag gcaatattaa tgtgttttct     4200

aaagtcattc aggtaaggaa gaattataaa tcaggtaact ggaccaacaa agggaacaca     4260

tataaagcta ttatgcatgc atggagccgt ttgaggctag ttttttaagg ccacaactcc     4320

agacccctga tttagactga gataggaaac agatcttgaa agaatcctta ttttaatgat     4380

acatgaatat catgttccta tacgcttaat aattggtctc tacgttttaa tgatacatga     4440

atatcatgtt cctatacgct taataattgg tctctacgac tttaatgttt ttgttttttt     4500

aagctgtgta agtattttta aatcaaagct taggaggtgt gttgcgtggt actatctgct     4560

gcaaatttat ctgaagtttg ttaatatttt ccaagatttt tgtcagcctt ttcataatcc     4620

agtcattaac aacctattgg taaacaagaa tgtaggtgcc agtagactaa accaaattta     4680

tttttccctg agtctgatat atatatgtat aaatataaat aactcaatcc atctgttcca     4740

ccaaaataac tcaaaagttg gatgattatt tgtcttccgc tttccagttc aaagggatga     4800

aattccttta gaacttgaaa gatgacacta gcgaacacca tgagaatact gtctacagtt     4860

tttggtacgt catcactaga acagtgaccc caaactgaat catgaaaggt ctgacatgat     4920

gtaatctgat cttccatgtg ttattttggc cccacatctc ttcttgattt tttagtctta     4980

tttccttagt gttattatca tacttcccct gatatatggc cgtacttcct ggccctgggc     5040

ttgacatttc ccacccttca ttctccatac atatgagatg tcagaaaaca tgcagtaatt     5100

gatattatgg gacacattgg aaaggattga atctggaatt agttctgtcc actgtggagg     5160

ggagaggaaa taatgctgta aatgttgagt tacagaaagt ccaatgtcaa atatagtttt     5220

tttgtttcct ttcaaatgta ttacagactg tgccaaaaca gttaccaatt cacactgtca     5280

atattaaagt ataccatagt atacaaatta gtcagtactt gctgttaatt ttaatatttc     5340

tgatttaaca gttagttatt aagtggtact tcattgctgt tttagccaac gttttaaaaa     5400

taatttggga gtttgactat tttggcttac gtactcattt ccttttctct gctaaaaatg     5460

ttttgcttgt gtgcgttcct gatttttgtc ttgtataatc ttgatctttg aaaaccctca     5520

aacatgtatt aaattgttgt aacttttttt cattagaggg aagacattaa ggggattggg     5580

gacatttgtt tcacacatct gcagtaatat gagttaacta atatttaaca agctctttct     5640

ttacattagc tgctgttctc atttgtatgt attgtcatat ttaatcctca gagtaaccta     5700

gtgaggtaaa tactgttgtt gtcagcatgg tgtaatcgag gaattgagtg agttgagcag     5760

aaaagttagg aaacttgctc agggtgataa tacagttagg agtgtcaggg cccatggaca     5820

aatcttgtca gtctccagaa cctaagatat actacgtcac tgacagcttg aacatttgta     5880

tttattgtac agaataaatt taagaaaaa                                       5909


<210> 1938
<211> 2171
<212> DNA
<213> Homo sapiens

<400> 1938
gatgtcacct ttcaacatca ccagtttgaa cttacaatac ttaagtcctg gcaagtcata       60

agtggggaaa atgtctctcc caagattcca aagagtaaac tttgggccat atgataatta      120

cattccagtc agtgaattaa gcaaaaaatc atggaatcag caacactttg ccctgttatt      180

tcccaaacca caacggccag gaaccaaaag gagatcaaaa ccttctcaaa tacgggacaa      240

cacggtttct ataattgatg aagaacaatt aagaggagat cgtagacaac cattatggat      300

gtaccgttct ttaatgagaa tttctgagag accatctgtt tatttagctg ccaggaggca      360

gcctctcaaa ccaactcgta ctgtcgaggt ggattctaaa gcagcagaaa ttggtaagaa      420

aggtgaagac aagacaacac agaaggacac aacagattcg gaatcagaat taaaacaagg      480

aaaaaaagat tcaaagaaag gcaaggatat agagaaagga aaagaagaaa agctagatgc      540

aaagaaagat agcaaaaaag gtaaaaagga tgcagagaag ggcaaagact cagcaacaga      600

atctgaagat gaaaaaggag gtgcaaagaa agataacaaa aaagataaaa aggattcaaa      660

caaaggcaaa gactcggcaa cagaatctga aggtgaaaaa ggaggtacag agaaagatag      720

caaaaaaggt aaaaaggatt caaagaaggg caaggattca gccatagaat tacaagctgt      780

aaaagcagat gaaaagaagg atgaggatgg aaaaaaagat gcaaacaaag gtgatgaatc      840

gaaggatgcc aagaaagatg caaaggagat taaaaaaggt aagaaagata agaagaagcc      900

cagtagtaca gacagtgact caaaggatga tgtcaagaaa gagtctaaga aggacgccac      960

gaaagatgcc aagaaagttg ccaagaaaga tactgagaaa gaatctgctg attcaaagaa     1020

ggatgcaaag aaaaatgcta agaaggatgc aaagaaggat gcaaagaaga atgcaaagaa     1080

ggatgaaaag aaggatgcaa agaagaaggg caagtaggcc ttggataaga atttgaaccg     1140

aaagaataat tcaaaagcat atttgatgaa acaatagtgg tagtctgcag ctgaatttgt     1200

gagaaaacaa gaggcctcaa agaattaaat aatttttaaa aggtggtaaa gaaggataca     1260

aaggagaact cagcagagat ttataaaaat atataagaaa gatgttaaga aaaattaagg     1320

ggggatccat tgaaagactt gaagaataca tatacttata ttcggggata tgaaggattc     1380

aatgaatgat ctctagaaag atttaaagaa gaatattcag ataaggatgt tgaagataat     1440

gacactaaat ctatggacac acacacacac acacacacac acacacacac acacacacac     1500

acacacacac agtttaatga aggcttaaag aatccaagga gacagatgtt gtatctatag     1560

atttaaaata atctcaagct gcatccacag atacaaaaaa atataggagc catgaaatga     1620

agttaaacac cttgtagaaa gcctactttc aagtaaatat agcattcctt tggcaaaaag     1680

aaaaaaaaag taaaagaaaa gaaaaaaaat gtattaccac ccgatgagcc tacatctttc     1740

tttctgaagt ttaaacaacc acagtcatgt ttatggttgt tggatgtgcc acttccaatc     1800

caaaagaagc acacttgtct cgctctgttg ccctggctgg agttcagtga catgatctca     1860

ggcttactac agcctccacc ttcaggttca agtgattctc ctgcctcagc ctctctggta     1920

gctgggatta cagggaagga aaatagctgg catttcttgc tggagaaagt tatcacaagt     1980

ggaaaggtta ccctagaaac aaaagatgac taccgtgagg atggattgga cattacacca     2040

cactggaaaa gtgaaacatc tcattcagtt ggtgatcttc ctgtcatgaa agttgcttga     2100

cagctctaat tacgaattga acacattaaa cacctggtga aattatcaat taaaaacatc     2160

tagtcaccat a                                                          2171


<210> 1939
<211> 1910
<212> DNA
<213> Homo sapiens

<400> 1939
ctagaggacc tgtgcaacaa cctcttgagg atcgaatctt cactcccgct gtctcagcag       60

tctacagcac ggtaacacaa gtggcaagac agccgggaac ccctacccca tccccttatt      120

cagcacatga aataaacaag gggcatccaa atcttgcggc aacgcccccg ggacatgcat      180

cgtcccctgg actctctcaa accccttatc cctctggaca gaatgcaggt ccaaccacgc      240

tggtataccc tcaaacccct cagacaatga attcacaacc tcaaacccgt tctccgtttt      300

tccagaggcc tcaaatacag cctcctagag ctaccatccc gaacagcagt ccttccattc      360

gtcctggtgc acagacaccc actgcagtgt accaggctaa tcagcacatc atgatggtta      420

accatctgcc catgccgtac ccagtgcccc aggggcctca gtactgtata ccacagtacc      480

gtcatagtgg ccctccttat gttgggcccc cccaacaata tccagttcaa ccaccggggc      540

caggtccttt ttatcctgga ccaggacctg gggacttccc caatgcttat ggaacgcctt      600

tttacccaag tcagccggtg tatcagtcag cacctatcat agtgcctacg cagcaacagc      660

cgcctccagc caagagagag aaaaaaacta taagaattcg ggatccaaac cagggaggta      720

aagacataac agaggagatt atgtctggag gtggcagcag aaatcctact ccacccatag      780

gaagacccac gtccacacct actcctcctc agcagctgcc cagccaggtc cccgagcaca      840

gccctgtggt ttatgggact gtggagagcg ctcatcttgc tgccagcacc cctgtcactg      900

cagctagcga ccagaagcaa gaggagaagc caaaaccaga tccagtgtta aagtctcctt      960

ccccagtcct taggctagtc ctcagtggag agaagaaaga acaagaaggc cagacatctg     1020

aaactactgc aatagtatcc atagcagagc ttcctctgcc tccatcacct accactgttt     1080

cttctgttgc tcgaagtaca attgcagccc ccacctcttc tgctcttagt agccaaccaa     1140

tattcaccac tgctatagat gacagatgtg aactctcatc cccaagagaa gacacaattc     1200

ctatacccag cctcacatct tgcacagaaa catcagaccc tttaccaaca aatgaaaatg     1260

atgatgatat atgcaagaaa ccctgtagtg tagcacctaa tgatattcca ctggtttcta     1320

gtactaacct aattaatgaa ataaatggag ttagcgaaaa attatcagcc acggagagca     1380

ttgtggaaat agtaaaacag gaagtattgc cattgactct tgaattggag attctcgaaa     1440

atcccccaga agaaatgaaa ctggagtgta tcccagctcc catcacccct tccacagttc     1500

cttcctttcc tccaactcct ccaactcctc cagcttctcc tcctcacact ccagtcattg     1560

ttcctgctgc tgccactact gttagttctc cgagtgctgc catcacagtc cagagagtcc     1620

tagaggagga cgagagcata agaacttgcc ttagtgaaga tgcaaaagag attcagaaca     1680

aaatagaggt agaagcagat gggcaaacag aagagatttt ggattctcaa aacttaaatt     1740

caagaaggag ccctgtccca gaaacatcga atgaatgctg aaattcctag tctggtttct     1800

tcagtggtgt gtttgtgttt tagtacaacc tgcaaaagag ttactccatt gtctaaaaat     1860

gcaaatgaga atttccaaat atacaaaatg cctccaaggt atatgtcacg                1910


<210> 1940
<211> 1136
<212> DNA
<213> Homo sapiens

<400> 1940
cagaaacatc gaatgaatgc tgaaattcct agtctggttt cttcagtggt gtgtttgtgt       60

tttagtacaa cctgcaaaag agttactcca ttgtctaaaa atgcaaatga gaatttccaa      120

atatacaaaa tgcctccaag ctcaaatagc tataactgta ccaaagacat ggaagaaacc      180

aaaagatcgg acccgaacca ctgaagagat gttagaggca gaattggagc ttaaagctga      240

agaggagctt tccattgaca aagtacttga atctgaacaa gataaaatga gccaggggtt      300

tcatcctgaa agagacccct ctgacctaaa aaaagtgaaa gctgtggaag aaaatggaga      360

agaagctgag ccagtacgta atggtgctga gagtgtttct gagggtgaag gaatagatgc      420

taattcaggc tccacagata gttctggtga tggggttaca tttccattta aaccagaatc      480

ctggaagcct actgatactg aaggtaagaa gcagtatgac agggagtttc tgctggactt      540

ccagttcatg cctgcctgta tacaaaaacc agagggcctg cctcctatca gtgatgtggt      600

tcttgacaag atcaaccaac ccaaattgcc aatgcgaact ctggatcctc gaattttgcc      660

tcgaggacca gactttacac cagcctttgc tgattttgga aggcagacac ctggtggaag      720

aggcgtacct gtaagtgcaa gttccctaca actcacttag ttagacactg gcacagactc      780

catgaaatcc tacctcatgg caagacagca gcttttattc gttgattcta gtcaagaaga      840

agaagaagag gcaaagacta tcctttccat actcatatta aagcagataa agaatacact      900

tgagttcttt ttacttggca gaagctagtc tgcattaatt tggtcttgat tttttttttc      960

cctatttttt caattgaggt gacctgcaaa taggtttaaa aatagtgcca accatggcca     1020

gggatggtgg ctcaggtctg taatgctagc actttgtggg gtcaaggcag gaggatcact     1080

tgaggtcagg agttcaaggt cagcctgaca acaaagagag accctgtctc taccac         1136


<210> 1941
<211> 4675
<212> DNA
<213> Homo sapiens

<400> 1941
gcccccggga catgcatcgt cccctggact ctctcaaacc ccttatccct ctggacagaa       60

tgcaggtcca accacgctgg tataccctca aacccctcag acaatgaatt cacaacctca      120

aacccgttct ccgtttttcc agaggcctca aatacagcct cctagagcta ccatcccgaa      180

cagcagtcct tccattcgtc ctggtgcaca gacacccact gcagtgtacc aggctaatca      240

gcacatcatg atggttaacc atctgcccat gccgtaccca gtgccccagg ggcctcagta      300

ctgtatacca cagtaccgtc atagtggccc tccttatgtt gggccccccc aacaatatcc      360

agttcaacca ccggggccag gtccttttta tcctggacca ggacctgggg acttccccaa      420

tgcttatgga acgccttttt acccaagtca gccggtgtat cagtcagcac ctatcatagt      480

gcctacgcag caacagccgc ctccagccaa gagagagaaa aaaactataa gaattcggga      540

tccaaaccag ggaggtaaag acataacaga ggagattatg tctggaggtg gcagcagaaa      600

tcctactcca cccataggaa gacccacgtc cacacctact cctcctcagc agctgcccag      660

ccaggtcccc gagcacagcc ctgtggttta tgggactgtg gagagcgctc atcttgctgc      720

cagcacccct gtcactgcag ctagcgacca gaagcaagct caaatagcta taactgtacc      780

aaagacatgg aagaaaccaa aagatcggac ccgaaccact gaagagatgt tagaggcaga      840

attggagctt aaagctgaag aggagctttc cattgacaaa gtacttgaat ctgaacaaga      900

taaaatgagc caggggtttc atcctgaaag agacccctct gacctaaaaa aagtgaaagc      960

tgtggaagaa aatggagaag aagctgagcc agtacgtaat ggtgctgaga gtgtttctga     1020

gggtgaagga atagatgcta attcaggctc cacagatagt tctggtgatg gggttacatt     1080

tccatttaaa ccagaatcct ggaagcctac tgatactgaa ggtaagaagc agtatgacag     1140

ggagtttctg ctggacttcc agttcatgcc tgcctgtata caaaaaccag agggcctgcc     1200

tcctatcagt gatgtggttc ttgacaagat caaccaaccc aaattgccaa tgcgaactct     1260

ggatcctcga attttgcctc gaggaccaga ctttacacca gcctttgctg attttggaag     1320

gcagacacct ggtggaagag gcgtaccttt gttgaatgtt gggtcacgaa gatctcaacc     1380

tggccaaaga agagaaccca gaaagatcat cacagtttct gtaaaagaag atgtacacct     1440

gaaaaaggca gaaaatgcct ggaagccaag ccaaaaacga gacagccaag ccgatgatcc     1500

cgaaaacatt aaaacccagg agctttttag aaaagttcga agtatcttaa ataaattgac     1560

accacagatg ttcaatcaac tgatgaagca agtgtcagga cttactgttg acacagagga     1620

gcggctgaaa ggagttattg acctggtctt tgagaaggct attgatgaac ccagtttctc     1680

tgtggcttac gcaaacatgt gtcgatgtct agtaacgctg aaagtaccca tggcagacaa     1740

gcctggtaac acagtgaatt tccggaagct gctactgaac cgttgccaga aggagtttga     1800

aaaagataaa gcagatgatg atgtctttga gaagaagcag aaagaacttg aggctgccag     1860

tgctccagag gagaggacaa ggcttcatga tgaactggaa gaagccaagg acaaagcccg     1920

gcggagatcc attggcaaca tcaagtttat tggagaactc tttaaactca aaatgctgac     1980

tgaagccatc atgcatgact gtgtggtgaa gctgctaaag aaccatgatg aagaatccct     2040

ggagtgcctg tgtcgcctgc tcaccaccat tggcaaagac ttggactttg aaaaagcaaa     2100

gccacgtatg gaccagtact ttaatcagat ggagaaaatt gtgaaagaaa gaaaaacctc     2160

atctaggatt cggttcatgc ttcaagatgt tatagaccta aggctgtgca attgggtatc     2220

tcgaagagca gatcaagggc ctaaaactat cgaacagatt cacaaagagg ctaaaataga     2280

agaacaagaa gagcaaagga aggtccagca actcatgacc aaagagaaga gaagaccagg     2340

tgtccagaga gtggacgaag gtgggtggaa cactgtacaa ggggccaaga acagtcgggt     2400

actggacccc tcaaaattcc taaaaatcac taagcctaca attgatgaaa aaattcagct     2460

ggtacctaaa gcacagctag gcagctgggg aaaaggcagc agtggtggag caaaggcaag     2520

tgagactgat gccttacggt caagtgcttc cagtttaaac agattctctg ccctgcaacc     2580

tccagcaccc tcagggtcca cgccatccac gcctgtagag tttgattccc gaaggacctt     2640

aactagtcgt ggaagtatgg gcagggagaa gaatgacaag ccccttccat ctgcaacagc     2700

tcggccaaat actttcatga ggggtggcag cagtaaagac ctgctagaca atcagtctca     2760

agaagagcag cggagagaga tgctggagac cgtgaagcag ctcacaggag gtgtggatgt     2820

ggagaggaac agcactgagg ctgagcgaaa taaaacaagg gagtcagcaa aaccagaaat     2880

ttcagcaatg tcagctcatg acaaggctgc attatcagaa gaggaactgg agaggaagtc     2940

gaaatctatc attgatgaat ttctacacat taatgatttt aaggaagcca tgcagtgtgt     3000

ggaagagctg aatgcccagg gcctactaca tgtttttgtg agagtgggag tggagtccac     3060

cctggaaagg agccagatca ccagggatca catgggccaa ttactctatc agctggtaca     3120

gtcagaaaaa ctcagcaaac aggacttttt caaaggtttt tcagaaactt tggaattggc     3180

agatgacatg gccattgata ttccccatat ttggttgtac cttgctgaac tggtgacccc     3240

catgttaaaa gaaggtggaa tctccatgag agaacttacc atagaattta gcaaaccttt     3300

acttcctgtt ggaagagctg gggtcttgct atctgaaata ttgcacctac tatgcaaaca     3360

aatgagccat aagaaagtgg gagccttatg gagggaggct gacctcagct ggaaggactt     3420

tttaccagaa ggagaagatg tacataattt tcttttggag cagaagttgg acttcataga     3480

gtctgacagt ccctgttcct ctgaagcact ttcaaagaaa gaactgtctg ccgaagagct     3540

gtataagcga ctcgagaaac tcattattga ggacaaagcg aatgatgaac agatctttga     3600

ctgggtagag gctaatctag acgaaatcca gatgagttca cctacattcc ttagagcttt     3660

aatgactgct gtttgtaaag cagctattat agccgactct tctaccttca gagtggacac     3720

tgctgttatc aagcagagag tgccgatctt actcaagtac ctagactcag atacagagaa     3780

ggaactgcaa gcactttatg cactacaagc atcgatagta aaacttgatc aacctgccaa     3840

tttgctgcgg atgttttttg attgtctata tgacgaggag gtgatctccg aggatgcctt     3900

ctacaaatgg gagagcagca aggaccctgc agagcagaat gggaagggcg tggctctgaa     3960

atctgtcacg gcattcttca cgtggctgcg ggaagcagaa gaggagtctg aggataacta     4020

aaacttcaaa tacacaaaat gaaacaaaag aaacaattta agtatttttt taaaaagttt     4080

cacgtcttcg ccaatcacag tgcagcaagg ccaattctcg cagaaacccc cacgtgtgca     4140

cgagtgggag aggggaaaga gaaaaaaagg tgatcatgga ggaaaaaggt actggataaa     4200

agtaaacttc aaaccttagg gcgggagcac taaaaccaaa atacatgtat tatttataga     4260

aaatattttc tgttttaatc ttttcttttt aaacaaggac tcatacttaa aaaaatgttt     4320

agcaaaaaaa aaaaaagttg agaactttta atttatttta aggactgcaa atgccagtgt     4380

aattttttaa tttgcagttt ctgtaaacaa cttgtataat agaaaagcag agaaataaat     4440

ttccctcccc ttcaagatgc acctcatgtt tgttttaagg tatagcattt agtccagatt     4500

tgagaaagtt tggggtgaac aaggtaagaa agattttttt ttttttggca tcaaatcttt     4560

ctgcctgcct ctcagcttgc ttcagaaaat ttaaaaaatc acaatagtaa tcaaaacata     4620

cataacattg aaacagaagg aaatgctgtg gaccacagaa ctccaagaat tgttt          4675


<210> 1942
<211> 5046
<212> DNA
<213> Homo sapiens

<400> 1942
ccccatcccc ttattcagca catgaaataa acaaggggca tccaaatctt gcggcaacgc       60

ccccgggaca tgcatcgtcc cctggactct ctcaaacccc ttatccctct ggacagaatg      120

caggtccaac cacgctggta taccctcaaa cccctcagac aatgaattca caacctcaaa      180

cccgttctcc gggaggattc agacctatcc agtttttcca gaggcctcaa atacagcctc      240

ctagagctac catcccgaac agcagtcctt ccattcgtcc tggtgcacag acacccactg      300

cagtgtacca ggctaatcag cacatcatga tggttaacca tctgcccatg ccgtacccag      360

tgccccaggg gcctcagtac tgtataccac agtaccgtca tagtggccct ccttatgttg      420

ggccccccca acaatatcca gttcaaccac cggggccagg tcctttttat cctggaccag      480

gacctgggga cttccccaat gcttatggaa cgccttttta cccaagtcag ccggtgtatc      540

agtcagcacc tatcatagtg cctacgcagc aacagccgcc tccagccaag agagagaaaa      600

aaactataag aattcgggat ccaaaccagg gaggtaaaga cataacagag gagattatgt      660

ctggaggtgg cagcagaaat cctactccac ccataggaag acccacgtcc acacctactc      720

ctcctcagct gcccagccag gtccccgagc acagccctgt ggtttatggg actgtggaga      780

gcgctcatct tgctgccagc acccctgtca ctgcagctag cgaccagaag caagaggaga      840

agccaaaacc agatccagtg ttaaagtctc cttccccagt ccttaggcta gtcctcagtg      900

gagagaagaa agaacaagaa ggccagacat ctgaaactac tgcaatagta tccatagcag      960

agcttcctct gcctccatca cctaccactg tttcttctgt tgctcgaagt acaattgcag     1020

cccccacctc ttctgctctt agtagccaac caatattcac cactgctata gatgacagat     1080

gtgaactctc atccccaaga gaagacacaa ttcctatacc cagcctcaca tcttgcacag     1140

aaacatcaga ccctttacca acaaatgaaa atgatgatga tatatgcaag aaaccctgta     1200

gtgtagcacc taatgatatt ccactggttt ctagtactaa cctaattaat gaaataaatg     1260

gagttagcga aaaattatca gccacggaga gcattgtgga aatagtaaaa caggaagtat     1320

tgccattgac tcttgaattg gagattctcg aaaatccccc agaagaaatg aaactggagt     1380

gtatcccagc tcccatcacc ccttccacag ttccttcctt tcctccaact cctccaactc     1440

ctccagcttc tcctcctcac actccagtca ttgttcctgc tgctgccact actgttagtt     1500

ctccgagtgc tgccatcaca gtccagagag tcctagagga ggacgagagc ataagaactt     1560

gccttagtga agatgcaaaa gagattcaga acaaaataga ggtagaagca gatgggcaaa     1620

cagaagagat tttggattct caaaacttaa attcaagaag gagccctgtc ccagctcaaa     1680

tagctataac tgtaccaaag acatggaaga aaccaaaaga tcggacccga accactgaag     1740

agatgttaga ggcagaattg gagcttaaag ctgaagagga gctttccatt gacaaagtac     1800

ttgaatctga acaagataaa atgagccagg ggtttcatcc tgaaagagac ccctctgacc     1860

taaaaaaagt gaaagctgtg gaagaaaatg gagaagaagc tgagccagta cgtaatggtg     1920

ctgagagtgt ttctgagggt gaaggaatag atgctaattc aggctccaca gatagttctg     1980

gtgatggggt tacatttcca tttaaaccag aatcctggaa gcctactgat actgaaggta     2040

agaagcagta tgacagggag tttctgctgg acttccagtt catgcctgcc tgtatacaaa     2100

aaccagaggg cctgcctcct atcagtgatg tggttcttga caagatcaac caacccaaat     2160

tgccaatgcg aactctggat cctcgaattt tgcctcgagg accagacttt acaccagcct     2220

ttgctgattt tggaaggcag acacctggtg gaagaggcgt acctttgttg aatgttgggt     2280

cacgaagatc tcaacctggc caaagaagag aacccagaaa gatcatcaca gtttctgtaa     2340

aagaagatgt acacctgaaa aaggcagaaa atgcctggaa gccaagccaa aaacgagaca     2400

gccaagccga tgatcccgaa aacattaaaa cccaggagct ttttagaaaa gttcgaagta     2460

tcttaaataa attgacacca cagatgttca atcaactgat gaagcaagtg tcaggactta     2520

ctgttgacac agaggagcgg ctgaaaggag ttattgacct ggtctttgag aaggctattg     2580

atgaacccag tttctctgtg gcttacgcaa acatgtgtcg atgtctagta acgctgaaag     2640

tacccatggc agacaagcct ggtaacacag tgaatttccg gaagctgcta ctgaaccgtt     2700

gccagaagga gtttgaaaaa gataaagcag atgatgatgt ctttgagaag aagcagaaag     2760

aacttgaggc tgccagtgct ccagaggaga ggacaaggct tcatgatgaa ctggaagaag     2820

ccaaggacaa agcccggcgg agatccattg gcaacatcaa gtttattgga gaactcttta     2880

aactcaaaat gctgactgaa gccatcatgc atgactgtgt ggtgaagctg ctaaagaacc     2940

atgatgaaga atccctggag tgcctgtgtc gcctgctcac caccattggc aaagacttgg     3000

actttgaaaa agcaaagcca cgtatggacc agtactttaa tcagatggag aaaattgtga     3060

aagaaagaaa aacctcatct aggattcggt tcatgcttca agatgttata gacctaaggc     3120

tgtgcaattg ggtatctcga agagcagatc aagggcctaa aactatcgaa cagattcaca     3180

aagaggctaa aatagaagaa caagaagagc aaaggaaggt ccagcaactc atgaccaaag     3240

agaagagaag accaggtgtc cagagagtgg acgaaggtgg gtggaacact gtacaagggg     3300

ccaagaacag tcgggtactg gacccctcaa aattcctaaa aatcactaag cctacaattg     3360

atgaaaaaat tcagctggta cctaaagcac agctaggcag ctggggaaaa ggcagcagtg     3420

gtggagcaaa ggcaagtgag actgatgcct tacggtcaag tgcttccagt ttaaacagat     3480

tctctgccct gcaacctcca gcaccctcag ggtccacgcc atccacgcct gtagagtttg     3540

attcccgaag gaccttaact agtcgtggaa gtatgggcag ggagaagaat gacaagcccc     3600

ttccatctgc aacagctcgg ccaaatactt tcatgagggg tggcagcagt aaagacctgc     3660

tagacaatca gtctcaagaa gagcagcgga gagagatgct ggagaccgtg aagcagctca     3720

caggaggtgt ggatgtggag aggaacagca ctgaggctga gcgaaataaa acaagggagt     3780

cagcaaaacc agaaatttca gcaatgtcag ctcatgacaa ggctgcatta tcagaagagg     3840

aactggagag gaagtcgaaa tctatcattg atgaatttct acacattaat gattttaagg     3900

aagccatgca gtgtgtggaa gagctgaatg cccagggcct actacatgtt tttgtgagag     3960

tgggagtgga gtccaccctg gaaaggagcc agatcaccag ggatcacatg ggccaattac     4020

tctatcagct ggtacagtca gaaaaactca gcaaacagga ctttttcaaa ggtttttcag     4080

aaactttgga attggcagat gacatggcca ttgatattcc ccatatttgg ttgtaccttg     4140

ctgaactggt gacccccatg ttaaaagaag gtggaatctc catgagagaa cttaccatag     4200

aatttagcaa acctttactt cctgttggaa gagctggggt cttgctatct gaaatattgc     4260

acctactatg caaacaaatg agccataaga aagtgggagc cttatggagg gaggctgacc     4320

tcagctggaa ggacttttta ccagaaggag aagatgtaca taattttctt ttggagcaga     4380

agttggactt catagagtct gacagtccct gttcctctga agcactttca aagaaagaac     4440

tgtctgccga agagctgtat aagcgactcg agaaactcat tattgaggac aaagcgaatg     4500

atgaacagat ctttgactgg gtagaggcta atctagacga aatccagatg agttcaccta     4560

cattccttag agctttaatg actgctgttt gtaaagcagc tattatagcc gactcttcta     4620

ccttcagagt ggacactgct gttatcaagc agagagtgcc gatcttactc aagtacctag     4680

actcagatac agagaaggaa ctgcaagcac tttatgcact acaagcatcg atagtaaaac     4740

ttgatcaacc tgccaatttg ctgcggatgt tttttgattg tctatatgac gaggaggtga     4800

tctccgagga tgccttctac aaatgggaga gcagcaagga ccctgcagag cagaatggga     4860

agggcgtggc tctgaaatct gtcacggcat tcttcacgtg gctgcgggaa gcagaagagg     4920

agtctgagga taactaaaac ttcaaataca caaaatgaaa caaaagaaac aatttaagta     4980

tttttttaaa aagtttcacg tcttcgccaa tcacagtgca gcaaggccaa ttctcgcaga     5040

aacccc                                                                5046


<210> 1943
<211> 2656
<212> DNA
<213> Homo sapiens

<400> 1943
gaagcgcgct aggttggctc ttctgcgcgc ctgcgccttg gcgagctctg cgcaggcgca       60

tttccaacgc ttggaggaga gggcggggtg tcgtttcctt tcgctgatgc aagagcctag      120

tgcggtggtg ggagaggtat cggcaggggc agcgctgccg ccggggcctg gggctgaccc      180

gtctgacttc ccgtccgtgc cgagcccact cgagccgcag ccatgtctgg ggacgagatg      240

atttttgatc ctactatgag caagaagaaa aagaagaaga agaagccttt tatgttagat      300

gaggaagggg atacccaaac agaggaaacc cagccttcag aaacaaaaga agtggagcca      360

gagccaactg aggacaagga tttggaagct gatgaagagg acactaggaa aaaagatgct      420

tctgatgatc tagatgactt gaacttcttt aatcaaaaga aaaagaagaa aaaaactaaa      480

aagatatttg atattgatga agctgaagaa ggtgtaaagg atcttaagat tgaaagtgat      540

gttcaagaac caactgaacc agaggatgac cttgacatta tgcttggcaa taaaaagaag      600

aaaaagaaga atgttaagtt cccagatgag gatgaaatac tagagaaaga tgaagctcta      660

gaagatgaag acaacaaaaa agatgatggt atctcattca gtaatcagac aggccctgct      720

tgggcaggct cagaaagaga ctacacatac gaggagctgc tgaatcgagt gttcaacatc      780

atgagggaaa agaatccaga tatggttgct ggggagaaaa ggaaatttgt catgaaacct      840

ccacaagtcg tccgagtagg aaccaagaaa acttcttttg tcaactttac agatatctgt      900

aaactattac atcgtcagcc caaacatctc cttgcatttt tgttggctga attgggtaca      960

agtggttcta tagatggtaa taaccaactt gtaatcaaag gaagattcca acagaaacag     1020

atagaaaatg tcttgagaag atatatcaag gaatatgtca cttgtcacac atgccgatca     1080

ccggacacaa tcctgcagaa ggacacacga ctctatttcc tacagtgcga aacttgtcat     1140

tctagatgtt ctgttgccag tatcaaaacc ggcttccagg ctgtcacggg caagcgagca     1200

cagctccgtg ccaaagctaa ctaatttgct aatcactgat tttgcaaagc ttgttgtgga     1260

gatgtggctg gacaggtttg ccatcagagt ggatataccg ttgtattaaa aacaagataa     1320

aaaagctgcc aagatttttg gcgagtggtt ggtctgaagt ccttgcaaga cgctgatgct     1380

caagctgttg acatactcat tgcctacttt aacacctgtc agagaaacgt gatatggggt     1440

aaggaggtgc ttttttaaaa tcgttcatag acttctgtaa aatgcaagat aaattaaagt     1500

tattataaca gtgattcttt caatttggtt tgtccttcag ttttcttttc tataaatgtg     1560

cttggtgaaa tcagcaagaa accaaccata taaaacagtg tgtgccgggc tctgactgag     1620

aaactgaaca atggcaggcg cttcatctgg gcagccattt ttcttctctg cttctcttga     1680

gatacatagt taaagtagac acggcctccc acgcgagtgt ggtgggacct tgagacttag     1740

gaggattgcc tgttttcagt gtccagggaa tgactccata gatttgaatt cttttccgta     1800

tgtggggatg gttgctacta cctcaccgcc aagtcctccc ccagctgtta ccacatgagg     1860

gaatacaagg tgctaggtac cctccttcct cgttggccac taagaggtct tagaaacata     1920

gcctgtaaat gtgtcttgta actggcacac taaaaaagat cctagttgag catctctctt     1980

ggtgaggaag cgatgtgtgt gcggttcagg aaactcctcc aagaggagga ggagtccaaa     2040

cagggatgcc agaggaagct ttccgttttc ctagccaact tgtgttctgg gtttgaaaaa     2100

gacccaccac aaatgctttt tctattttct gatttaaaag tcgcttttga atatgaccat     2160

gagaaaccaa gaaatgctgc ttgtgtggtg ctctgcttcc tgaggatttg gctggaaggg     2220

gattctccgc tggcacatgg gagaaggcca tcttctgtgt cggtgctgtg atctgccttg     2280

ttctcacttg ctgaggataa gggcatacac gctgctcctc gctttcttgt tgcccgactt     2340

cgtactaagc agctcaggag cagtcactca gacccaaatg tcttgactgt gttgttttta     2400

atcactgtga cccttaaagt acaggccaag tgttgtcaaa caccttggct aaaacagtgg     2460

agggtgatgg gtaaagcagt agagggccct caacccacac actggctgaa actgccacca     2520

actgccacga tgaacccaac tgctgtttat gcccccattt tccttttttt gtatctacac     2580

ccacacgatt cccaatgttg gatatttcta catgaataaa gcaaggatca gtgcctctta     2640

tgtaattaac gctcca                                                     2656


<210> 1944
<211> 7150
<212> DNA
<213> Homo sapiens

<400> 1944
gggccgcgcg tggcggcggc gatgggcgag ggcgggctgc ccccggcctt ccagctgctg       60

ctgcgcgcgt gtgaccaggg cgacacggag acggcgcggc ggctgctgga gccgggggcg      120

gcggagccag ccgagcgcgg cgcggagccg gaggcgggcg cggagccggc gggggccgag      180

gtggccgggc ccggggccgc agcggcgggg gcagtcgggg ctccggtgcc cgtggattgc      240

tcggacgagg cgggcaacac cgcactgcag ttcgccgcgg ccgggggcca cgaaccgctg      300

gtgcgcttcc tgctgcgccg cggtgcctcg gtcaacagcc gcaaccacta cggctggagc      360

gcgctcatgc aggcggccag atttgggcat gtgagtgtgg cacacctcct gttggatcac      420

ggggctgatg tcaatgccca gaaccggctg ggggccagtg tgctcactgt ggcttctcgg      480

ggcggccacc tgggtgtggt gaagctgctc ctggaagccg gtgcctttgt ggaccatcac      540

cacccttcag gcgagcaact ggggttgggc ggcagcaggg atgagccctt ggacatcaca      600

gccctgatgg ctgccatcca gcacgggcac gaggccgtgg tgcgtctact gatggagtgg      660

ggcgcggacc ccaaccacgc agcccggacc gtgggctgga gcccgctgat gctggccgca      720

ctcactgggc ggcttggagt ggcccagcag ctggtggaga agggcgccaa ccctgaccac      780

ctcagcgtgc tggagaagac cgccttcgag gttgcactgg actgcaagca cagggacctt      840

gtagactacc tggacccgct gaccaccgtc aggcccaaaa cagatgagga gaaaaggcga      900

cctgatattt tccatgcatt gaaaatggga aacttccagc tggtcaaaga gattgccgat      960

gaagacccca gccacgtgaa cttggtcaat ggggacgggg cgacgccact gatgctagca     1020

gctgttacgg ggcagctggc tctggtgcag ctgctggtgg agaggcacgc ggatgttgac     1080

aagcaggaca gcgtgcatgg ctggacggcc ctcatgcagg caacctacca tgggaataag     1140

gaaattgtga aatatctgct aaaccaaggg gccgatgtca ctcttcgtgc aaaaaatgga     1200

tacacggcct ttgacctggt gatgctgctg aatgatcccg acacggaact tgttcgactg     1260

ctggcatctg tctgcatgca ggtgaataaa gacaaaggcc ggccgagcca ccagcctccc     1320

ctgccccact cgaaggtccg acagccctgg agcatcccag tgctgcccga tgacaagggt     1380

ggactgaagt cctggtggaa ccgaatgtcc aatcggttcc gaaagctcaa actgatgcag     1440

acgctgcccc gtgggctgtc cagcaaccag cctttgcctt tctctgacga gcctgagcca     1500

gctctggact ccacaatgag ggctgccccc caggacaaga caagccgctc tgcactccct     1560

gatgcggccc ctgtgaccaa agacaatggt cctgggagca caagaggaga aaaggaagac     1620

acgttattga caaccatgct tcgaaacgga gctcccctca ccagactccc gagtgacaag     1680

ctgaaagcag tcatcccccc attcctaccc ccttccagtt ttgagctgtg gagctctgat     1740

cggtcccgga cgcgtcacaa cgggaaggca gaccccatga agactgcgct gccccagaga     1800

gccagcaggg gccaccccgt gggcggcggg ggcacagaca ctacacccgt caggcctgtt     1860

aaatttccaa gcctccccag aagcccagcc tcttctgcca attctggaaa cttcaaccac     1920

tcgcctcatt catcgggcgg ctccagtggg gtaggtgtga gccggcacgg tggggagctg     1980

cttaaccgct caggtggcag catagacaat gtcttgtccc aaatcgctgc ccagaggaaa     2040

aaagcagccg gattattgga gcagaaaccc agccatcggt caagccctgt ggggccagca     2100

ccggggtcca gcccgtctga gcttccagcc tcccctgcag gtggcagcgc tcctgttggc     2160

aagcagaaat tggagaccag caaaaggcct ccatctggaa cttccactac ctccaagagc     2220

acctctccaa ccctcacgcc ctccccctca cccaaagggc acactgcaga gtcctcagtg     2280

tcttcctcgt catcccatcg gcagtccaag agcagtgggg gctccagcag tggcaccatc     2340

acagatgagg atgaactgac tggaatcctt aagaaattat cacttgagaa atatcagccc     2400

atttttgagg aacaagaggt ggacatggaa gcgttcctca cactgactga cggtgacttg     2460

aaggagctgg gaattaagac agatgggtcc aggcagcaga ttctggcagc gatttctgaa     2520

ctgaacgcag gcaagggacg cgagagacaa attttacagg aaaccattca caactttcac     2580

tcttcctttg agagcagtgc cagcaacacc agggcccctg gcaacagccc ctgtgcgtga     2640

tcctccttcc cgcagccacc agcgtgagct ctctgaatcc cgggacccct tcacgtggcc     2700

acagccccag ccctgccccc gtcacactgc tgtgccttag tcatgttgtt ccctttgctc     2760

gggatgccca cttcacgtcg acggcattca ttggtagtac ttcttgctgc aacaaacttc     2820

aacacacaga gacagattcc catgtaacag tccagtgggg gtgcttctgc ttggcaggtt     2880

ggttcacaca gtgatgcagg gactcagctc ctttcatcct gtgctctgcc ctccccggga     2940

gcctcagagt ttgcttctgg ctggcggcaa gggaaaggga cgatggagaa ggcacggctg     3000

cttcttacct gccttgctct taactgacac acatcactcc tgctcacgtc ctcttggcca     3060

ctggtagtca tgtggcccca cctggatgca gaggaggcca ggatgtgcag tctccacata     3120

gtggcttccc agcaacaact tttgacttag atggggggta tgtattatgg tgagaggtta     3180

gccttcctgg cacatcttcc cttaaaactt ctaacttgcc cctcctagtc caagtcacct     3240

ctcagatgaa gtcttttttg accccctttc agccactggg tcccttagtg ctgtgtatgt     3300

gactgctgta gcattccact gcacctgctg catacagctt acattggaga tgtgtatgtc     3360

aaacgcattt ttctttattg caaagagagt ctattataga aggaaagaag tggaggcctg     3420

ctgtgtggat cccttcttct tcctagcttt cagtttcctt atctgcaaag tggaaggtca     3480

gaccagatga tgctctggta ctccacagtg ctcacctgta tcactgcagg gctttctgca     3540

ctgaaagtgg aagcagaagg ctaatgggtc acattgtgta aaggtctctg gtgctcaaag     3600

tttctaggca aagaagtgaa aatttggaat tttgtctaca tcctattaat gctgtgttcc     3660

tcaaaaggga attggcttgt gtagtttcct accatatcat attttattaa attagagggg     3720

ccctgacttt taaaacccac tggctttctg aagtgttttc cagtgaatga ctcattcagc     3780

cagtgcttgt tgcatttatg ttagctacca ggtgccaagt gtgcagacac aatacagagc     3840

cttcaggctc tcgacaggca agagaacacc tgtaaataga tggtcccgac attgagaggc     3900

agcatggtag agtgggcaga ccttgtgctc tggactcagg ttcaaagttc agatgaagct     3960

caatggcctc ttagttggag cttagaacca gtatgcccaa agtgctgggt ctgcaggaag     4020

tacccagtcg atggtaggct gcacagaatt ctgatctcta ccttgagcca tgctgagcca     4080

caagttggtc tccttgggag gtgccatctc tcatctgtcc ctcccccagc catgaaagcc     4140

cattccccta tgctggcttt cagaggctgt cgttaactta ctgcccagag cctcgtagtt     4200

ttcttcccct gccctgatgg ttgggtgttt ttcctttaaa ttctctcagc cttacactca     4260

cagaagccaa ctttccacag gactgaagac aaagtgtttc atttagctgt tactgataga     4320

cacctttaca aaggttacta atgtcccagc ctttttaagg agacacactc attcatcccc     4380

tactatgtgc tggcagcttt acctttgtca tttcatcctc atggccaccc tggaggtggc     4440

attgtgtaac ctcatcttgc acattcggga aacggatgct taggagaggg aagcagcttg     4500

ccagttaaac agcccagaag gagcagatct ggggtcagaa ccggacctgg tgggcttgca     4560

agcctgtgcc ttttccacta actcctatag actcctggag ctagaagcac ttgtgattct     4620

tgttttaatt tactgatggc ttcaggggtt aacagtaggc ctagaattgt ttgcctctga     4680

aattcatggc ccctgacgtt atgtgctttg aggttttgtg cctgcttttt gctgtggtcc     4740

tgtttttttc ataacaatat actggtatag cttccactca ggtaagtttg attgaacaat     4800

gatacacagc tgcaccgggg ggtcaccttt tcacaaatgt agacctccat gaactcattg     4860

gatgaccctg gacagagcgg ggctattccc attttgcaga caggacagca gaggctccag     4920

acaatgcctt tcctttcttt ttcactggac tcaagtgtcc aaggcttttc atcctaggaa     4980

gtttgtgtgc tggttcacaa gaggtccctg gcaccctttc tggggatgtt tggatgcggc     5040

tggtaggcag ggaagagaaa gggcacccca gcgggggcat gtgtggaggc agcacggaac     5100

atgtaggtta tagatcgtca gggaggaggg gtcagttggg tgcttgtttt tctgattttt     5160

ggtccttgat cacccccttc ccttcccaca cgtgtcccca gcctgcctgt ggctgttccc     5220

cccacaagaa gcacctccct tgcttggcaa ccttcaccag catttcccaa aagtatgctc     5280

ctgggaaccc tagttccaca ggataatagg tttttcataa agaaacgtag ggtgtgtatg     5340

tgaaagtggg gtgaggttcc ctggttgagt aggtttggca gacactaaag cgagctacac     5400

gatcatcttt gctacaggcc tctcacaacc ttcagcatgc cagcatgggt caggcctctt     5460

cacagggcca agaaactcat agcatctccc acattactct catcacttct ccaaggtgct     5520

tttgcaagac tggaattcct tggacaccat tggagaagcc ccgctttttc tggaacagcg     5580

gcaaccaaga ggccttgcag ccctggaagt gggtcagggc ccttggtggt cacctttttc     5640

tccccagcag ctctgcagag gtggcctgct tggcagtggg acatcagggg accggtcctg     5700

ctttgagatg gcagggtccc tgttctgaga gctctccagc ctgagggcat tgagctgagg     5760

ctccaccctg agctctcctg cagggtggag ggcattgttt cccagcaccc aggcagtgtc     5820

ttgctggtgt gtcgtgagtg ctggatgtcc aagtccctgc tggccacgga gggctcctgc     5880

ctctcttctt cagcgccaca aaattacatg gaggccagct ggttttgtga ggagattgtt     5940

tattttttaa ttcttttgtt taccgaacgt ttactgagca tctaccctgt gccagcccta     6000

ctcgtacgct ctgtctccaa agatgaaaaa ggacttctct gccctcaagg gaaccccaca     6060

gtatcttaga ggagacaatc atgtcggtga gatggtgtgg tgatgaagcc tgctgggtat     6120

acagctcagg gaaagtcatc gatgatggct caggctcagc ctgggcacgc cccagaggag     6180

agagatggag tggggcctca aagggcaggt ttaggcagaa aagaaaaagg gcattccagc     6240

tggggcatgt gcaaaggcag cacgtaatgt gtaagttcta gatcgtcagg gaggaagggt     6300

cagttgggtg cctgtttttc tgtttttagt cctttaaaat gagtagaagc aacctgttac     6360

cctggaaaga gcactggaca tagacctagt gctgcgtgat gttgagcacg tttcttcttc     6420

cctttgagtc ccagtttccc ttttggttac agggggatag tagcccccag ggatcatgtg     6480

aaagtgagaa agcccttttc acactgtgga gcggtgcaga tgtgggaaac ctcaaagatg     6540

gttgcccatt ttaaatcctt tcatctctca tctctctttc ttctctccct tctgccctga     6600

cgtagccatg gttgggtggg tgaggccaga agaaactgcc tccggcaaga ggtagcagcc     6660

gctcaggtgg ctctgctggc atcggagccc acagaagtga ggagtggccg atggacctgc     6720

cctccaaatg tgcctgactc tgggtcttgc tgtcactgga tttcctggca tggcagacag     6780

aaagaaagat agtttgacca agtcgtagaa gctgatccag cgggtaaaaa gggggcaggg     6840

aactcgtccc ttttattctt gcctcagagc tgcctgaaga catgggccag gccggaggct     6900

ggacaacttt ggataacgct gacctgtact tccaagtaaa tgcctcctga agagcccggg     6960

acccttcctg ggagaattct gcagccagaa tgaaggtgcc atcagcagga ggcactgtga     7020

agcaccatcc tgtcgctgtc cttgtccatt cctagcaagt taatcgtgtc ttgttaacca     7080

gcagttcctg ttcaacgtgt aaagagacct gatgttttcc ctaataaagc tgataacaga     7140

ttttgcagga                                                            7150


<210> 1945
<211> 1476
<212> DNA
<213> Homo sapiens

<400> 1945
gaaagagcag aagaggaggt ggggtggagg gagcagagcc agggattagg ggactactga       60

ggctctggag atgagaccgc caggagtcct tccccaccat gagccccctc cactcctgca      120

gctggaggag tttttcccag tctcagtgct gccctggggc gagagagact gaacaagctg      180

tttgggtggg aagagaatgg aggaagttga cagggatggg cggggcccgt gggggggctg      240

accaggaacc cagcttcctg ctcagtaccc aggcatccag cccccagctc acccccaccc      300

cttccagccc ccactcccct caggaaccca aggttccagc cctcctccca aatcccagcc      360

acccctcccc caccagtttc tcccctctag gggatggagg ctgagagacc ccaggaagaa      420

gaggatggtg agcagggccc ccctcaggat gaggaaggct ggccccctcc aaactccacc      480

actcggcctt ggcgatctgc tcctccatcc cctcctcctc cagggacccg ccacacagcc      540

ctgggacccc gctcggcctc cctgctctcc ctgcagactg aactccttct ggacctggtg      600

gctgaagccc agtcccgccg cctggaggag cagagggcca ccttctacac cccccaaaac      660

ccctcaagcc tagcccctgc cccactccgt cctctcgagg acagagaaca gctttacagc      720

actatcctca gtcaccagtg ccagcggatg gaagcccagc ggtcagagcc tcccctccct      780

ccaggggggc aagagctcct ggagttgctg ctgagagttc agggtggggg tcgaatggag      840

gagcaaaggt cccggccccc cacacacacc tgctgagact tgagccccaa ccagcccttc      900

cttgccactg gtctcaaagc tgggcagccc attgcatgcc ctcaactctt gcttggcagg      960

ggtaccagag actgaaagac acggcacaaa tctcaatatt catctcccac atcaccttcc     1020

ctgggaactg gacagggtga aagtcctcaa actctgggaa caggcgagat ggaacaggga     1080

tttaactccc cgcccacagg tccatgggag cttgaggcag taagggggat cccaggcacc     1140

catctcaagg agtggctggg agtcttttcc ctaacttgtg gggacaccac cagttgtcaa     1200

gctactaggc agtagggtct gagggctcag gcctccacct gagaggttat aacctgagag     1260

acagctctac ccttcctccc agtaagaagg gaaggtgggt gggcacctga gagattaaga     1320

ctattctccc agtcccacta ccagcacccc cgatccctga gactgagggg tttacgggct     1380

gtgaatggac cttcagccct gcccaccctc cctccccact gctgctgagt ctgtctgatg     1440

ttttggttgt gtgaataaat ataattcccc tctgga                               1476


<210> 1946
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 1946
ccggagcggg gatcacctca acttgactgt ggtcccccag ccctccaaga aatgcccata       60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa      120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt      180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt      240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca      300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc      360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc      420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc      480

tcctccatcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc      540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg      600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc      660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg      720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct      780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc      840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc      900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac      960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga     1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg     1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg     1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct     1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc     1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta     1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct     1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat     1440

ataattcccc tctgga                                                     1456


<210> 1947
<211> 3572
<212> DNA
<213> Homo sapiens

<400> 1947
ctatccgctg gtggaggtga gggcgcccgg caggccgccc tgcaggcggc agggcatgag       60

gccgccccga gagtccccag ggggctgcgc tgccccccag ccaggaggaa aggccctcga      120

ggggcgcagg cggacgggaa cagggcgtca ctgagggcta caatggcacc atctttgcct      180

acggccagac aggcagcggg aagtccttca ccatgcaggg cctgccggat ccgccctccc      240

agagaggcat catccccagg gccttcgagc acgtgttcga gagcgtccag tgtgcagaga      300

acactaagtt cctggtccgg gcctcctacc tggagatcta caatgaagat gtccgggacc      360

tccttggggc tgacaccaag cagaagctgg agctgaagga gcacccagag aagggcgtgt      420

acgtgaaggg gctgtccatg cacacggtgc acagcgtggc ccagtgtgag cacatcatgg      480

agactggctg gaagaaccgt tcggtcggct acacgctgat gaacaaggat tcctcacgct      540

cgcactccat cttcaccatc agcatcgaga tgtctgccgt ggatgagcgg ggcaaggacc      600

acctccgggc gggcaagctg aacctggtgg acctggcggg cagcgagcgg cagtccaaga      660

ccggggccac gggcgagcgg ctcaaggagg ccaccaagat caacctgtcg ctctcggcac      720

tgggcaatgt catctcggcg ctggtggacg ggcgctgtaa gcacgtcccc taccgtgact      780

cgaagctgac gcggctgctg caggactcac tgggcggcaa caccaagacg ctcatggtgg      840

cctgcctgtc gcctgcggac aacaactacg atgagacact cagcacgctg cgctacgcca      900

accgggccaa gaacatcagg aacaagccgc gcatcaatga ggaccccaag gatgcgctgc      960

ttcgcgagta ccaggaggag atcaagaagc tcaaggccat cctgacacag cagatgagcc     1020

ccagcagcct gtcagccctg ctgtccaggc aggtgccccc agaccctgtg caggtggagg     1080

agaagctgtt gccccaacct gtgatccagc atgacgtgga ggccgagaag cagctgatcc     1140

gggaggagta tgaagagcgc ctggcccggc tgaaagccga ctataaggcc gagcaggagt     1200

ctcgggccag gctggaggaa gacatcactg ccatgcgcaa ctcatatgac gtcaggctgt     1260

ccacgctgga ggagaacctg cggaaggaga cagaggctgt cctgcaggtg ggagtcctct     1320

acaaggctga ggtcatgtcc agggctgagt ttgccagcag cgctgagtac ccgcctgctt     1380

ttcagtatga gacagtggtg aaacccaagg tcttctccac gactgacact ctgcccagtg     1440

acgatgtctc caagactcag gtttcctcca ggtttgcgga gctgcccaag gtggaaccct     1500

ccaaatctga gatttctctg ggctccagtg agtcatcctc gctcgaagaa acctctgtgt     1560

ccgaggcttt ccctgggcct gaggagccct ccaacgtgga ggtctccatg cccactgagg     1620

agtccaggag cagatacttc ctggatgagt gcctcgggca ggaggccgct gggcacctgc     1680

tgggggaaca gaactacctc ccgcaagagg agccgcagga ggtgcccctg caggggttac     1740

taggcctgca ggacccgttt gccgaggtgg aagccaagct ggccagactc tcctccaccg     1800

tggccaggac agatgcaccc caggcagacg tccccaaggt ccctgtgcag gtccctgcgc     1860

cgacagacct gctggagccc agtgatgcca ggcccgaagc cgaggcggct gatgacttcc     1920

cgcccaggcc tgaggtagat ctggcctcgg aagtggcctt agaggtggtg cggacagcag     1980

agcctggcgt gtggttggag gctcaggccc cggtggccct ggtggctcag cctgagcccc     2040

tgccggccac agctggtgtg aagagggaga gcgtgggcat ggaggtggca gtgctgactg     2100

atgacccgct gcccgttgtg gaccagcagc aggtgctggc ccgtctgcag ctgttggagc     2160

agcaggttgt gggtggagag caggccaaga acaaggacct gaaggagaag cacaagcggc     2220

gcaagcgcta cgcagacgag cgcaggaagc agctggtggc tgccctgcag aactcggatg     2280

aggacagcgg ggactgggtg ctgcttaacg tctacgactc catccaggag gaagtgcggg     2340

ccaagagcaa gctgctggag aagatgcaga ggaagcttcg ggcagcagag gtggagatca     2400

aagatctgca gtccgagttt cagctggaga agatcgatta cttggccacc atccgccggc     2460

aggagcgtga ctccatgctc ttgcagcagc tcctggagca ggtgcagccc ctgattcgca     2520

gggactgtaa ctacagcaac ctggagaaga ttctgcgtga gtcctgctgg gacgaagata     2580

acggcttctg gaagatccca catcccgtca tcacaaaaac cagcctccca gtagcagttt     2640

caactgggcc acagaacaaa ccagcccgca aaacctctgc agcagacaat ggcgagccga     2700

acatggagga cgaccgctac aggctcatgc tcagtcggag caacagtgaa aacattgcca     2760

gcaactactt ccgatctaag cgggccagcc agatcctcag cacagacgcc aggaagagcc     2820

tcacacatca caactcgcca ccaggcctca gctgcccact cagcaacaac tctgccatcc     2880

cacccaccca ggcccctgaa atgccccagc cccggccctt ccgcctcgag tccctcgaca     2940

tccctttcac caaggccaag cgtaagaaaa gcaaaagcaa ctttggcagt gagcctctgt     3000

gagcacagct gcttgccatt gcctgcctta taggcatgta gagactgcca ggccctccca     3060

gggcagcccc aaccaggtct cctcccacct gccacacagc gctccggggc ctgagggctc     3120

cctcagccct gggaagacac attcccttcc ctgttcccca gagagcccac ctccgccctg     3180

ggcaggagcc cctcggaggc tgtatagtcc tccttagaga ggcctgctcc agctgttcat     3240

accacatcag tgtttccgtc tgctcacctg ccacagagcc cacacccatg cccaccagtg     3300

ttggtctttg cctcaaagcc tgagacctgc ttcacggcct tcaccagccc tgatggagag     3360

ggcagcagct gccacgtgga ggaagctcaa tatcagctgg gaaggaactg tgcctctgtc     3420

tgactggccc cacttcctaa gcactgccct gccccatggg gtggcacagg ggtcccacag     3480

caggtcttcc tgcactgccc acccctggct ggtctgtggc ccaaggaagg ccactccaca     3540

ttaagctgcc caataaactg cttttaagat aa                                   3572


<210> 1948
<211> 730
<212> DNA
<213> Homo sapiens

<400> 1948
agattgtttg tttgggaaat tttgcactct acaattcgta agatgaacaa acatgtcctg       60

aagatccaga aagagctgga agaagctaaa gagaaacttg ctaggcaaca caaacggcga      120

agtgatgatg acgacagaag cagtgacagg aaagacgggg ttcttgagga acaaatagaa      180

cgacttcagg aaaaagtgga atctgctcag agtgaacaaa agaatctttt cctcgttata      240

tttcagcggt ttatcatgat cttgaccgag cacctagtac gatgcgaaac tgatgggacc      300

agtgtattaa caccatggta taagaactgt atagagaggc tgcagcagat cttcctacag      360

gtatgtgggg aacttcgatt aggtaataac actattctca gccacaaaga tttttcatta      420

aaaaaaatcc ttgtcaaatt tgttaggagg ttatatagta cctgttagac cctttagttc      480

atgtccattt gctgctacca ttgctcatca gaatatttag gcttaaactg attctgtacc      540

acttagattc ctaattgcca cccccccaac aaccccccgc cccacctttt ttttgagatg      600

gcatctcact ctgttgccca ggctggagtt cagtgacacg atctcagctc actgcaacct      660

ccacctccta ggtttaagca attcttctgc ctcagcctcc catattgctg ggattacagg      720

cacccgtcac                                                             730


<210> 1949
<211> 5178
<212> DNA
<213> Homo sapiens

<400> 1949
ggcggaggca gcccgagggg gcggttgcat gtgtgccaga cgttcgtagc ccactgagct       60

tcctcacgcc ggctgtcgca gcgcctagcc ccacccggcg gcctctcctg cgcttccggg      120

gccgtggcga gctagtgcgc ctgcgtgccg gcccatccgc gcgccttgca gctgtccttg      180

cgtcggccag cggccagaca gttcctgcag cgcttaccgc ctggcctctc ggttccgcgg      240

cgcaccggag ggcagcatgt cgcggcggcg gcacagcgac gagaacgacg gtgggcagcc      300

tcacaaaagg agaaagacct ctgatgcaaa tgaaactgaa gatcatttgg aatctttaat      360

atgtaaagta ggagaaaaga gtgcctgctc tttggagagc aacctagaag gcttggctgg      420

tgttttggaa gctgatcttc ctaactacaa gagcaagatc ttaaggcttc tttgtacagt      480

tgcacgccta ttacctgaga agctgacaat ttatacaaca ttagttggac tactgaatgc      540

caggaattac aattttggtg gagaatttgt agaagccatg attcgtcaac ttaaagaatc      600

attgaaagca aacaattata atgaagccgt gtatttggtc cgttttttat ctgatcttgt      660

gaattgtcat gtgattgccg ccccatcaat ggttgctatg tttgaaaatt ttgtaagcgt      720

aactcaggaa gaagatgtac ctcaggtgcg acgagattgg tatgtgtatg catttctgtc      780

atctttgccc tgggttggaa aggagttgta cgaaaagaaa gatgcagaga tggaccgcat      840

ctttgccaac actgaaagct atcttaaaag acgccaaaag actcatgtac ccatgttaca      900

ggtatggact gctgataaac cacatccaca agaagagtat ttagattgcc tgtgggccca      960

gattcagaaa ttgaaaaagg atcgctggca ggaacggcac atcctaagac cttatcttgc     1020

ctttgacagc atcctgtgtg aagcactgca gcacaatctg cctcctttta caccacctcc     1080

tcacactgaa gattcagtgt acccaatgcc aagggtcatc ttcagaatgt ttgattacac     1140

agatgatccc gagggtcctg tcatgccagg gagtcattca gtggaaagat ttgtaataga     1200

agagaatctt cactgcatca ttaagtccca ctggaaggaa aggaagactt gtgctgcaca     1260

gttagtgagc tatccaggga agaacaagat ccccttgaac taccacatag ttgaggtgat     1320

ctttgcagag ctgtttcaac ttccagcacc ccctcacatt gatgtgatgt acacaacact     1380

cctcattgaa ctgtgcaaac ttcaacctgg ctctctaccc caagttcttg cacaggcaac     1440

tgaaatgcta tacatgcgtt tggacacaat gaacactacc tgtgtagaca ggtttattaa     1500

ttggttttct catcatctaa gtaacttcca gttccgttgg agctgggaag attggtcaga     1560

ttgtcttagt caagatcctg aaagtcccaa accgaagttt gtaagagaag ttctagaaaa     1620

atgtatgagg ttgtcttacc atcagcgtat attagatatt gttcctccta ccttctcagc     1680

tctgtgtcct gcaaacccaa cctgcattta caagtatgga gatgaaagta gcaattctct     1740

tcctggacat tctgttgccc tctgtttagc tgttgccttt aaaagtaagg caaccaatga     1800

tgaaatcttc agcattctga aagatgtacc aaatcctaac caggatgatg acgacgatga     1860

aggattcagt tttaacccat tgaaaataga agtctttgta cagactctgc tacacttggc     1920

agccaaatca ttcagccact ccttcagtgc tcttgcaaag tttcatgaag tcttcaaaac     1980

cctagctgaa agtgatgaag gaaagttaca tgtgctaaga gttatgtttg aggtctggag     2040

gaaccatcca cagatgattg ctgtactagt ggataagatg attcgtacac aaatagttga     2100

ttgtgctgcc gtagcaaatt ggatcttctc ttcagaacta tctcgtgact ttaccagatt     2160

gtttgtttgg gaaattttgc actctacaat tcgtaagatg aacaaacatg tcctgaagat     2220

ccagaaagag ctggaagaag ctaaagagaa acttgctagg caacacaaac ggcgaagtga     2280

tgatgacgac agaagcagtg acaggaaaga cggggttctt gaggaacaaa tagaacgact     2340

tcaggaaaaa gtggaatctg ctcagagtga acaaaagaat cttttcctcg ttatatttca     2400

gcggtttatc atgatcttga ccgagcacct agtacgatgc gaaactgatg ggaccagtgt     2460

attaacacca tggtataaga actgtataga gaggctgcag cagatcttcc tacagcatca     2520

ccaaataatc cagcagtaca tggtgaccct ggagaacctt ctcttcactg ctgaattaga     2580

ccctcatatc ttggccgtgt tccagcagtt ctgtgccctg caggcctaag ggtcattttt     2640

tcctcatgtc aaggtttttt ttgatatctt aaaataattt gtcttatttt ttgatggttt     2700

gaatgcttgc tttcttgtag tatcctttca cttcttaaag gaaacaaagg ggaagaggac     2760

agtgaatgaa catggcatta cttttaattg ccctgaaaag caaatacttc ctaacggcag     2820

taatgtgact atgaccatga tatattatat atgtgacaga tacaaattct ctgtgatcag     2880

tttgttattt tttttctcct taaggcacaa aataattggt ttgaggtatg tgaaacacta     2940

gaggtcaacc ttacatagta tatagaactg atgggtttac ccagctaccc agtagcataa     3000

cttttcacag ctcggggatg aattaacatg gctgaaataa aactaaaagt atggttttta     3060

aactttggca tttcatgatt tatcatctca ctctactcta aaactggtgg tttcttactg     3120

aaggtgttct ccatttgaaa ttttatcttc aaagtatttt taagtagtat ctttaagaca     3180

tgacttgtta gtaataaaag tgttactagt tggaagagta gctctcaaat ttgtcttaat     3240

gtaaatcacc tgggaatctt tcaagttatt ttgaaattta aaccaccgtc tgggggtgga     3300

acgcagacat cctcagtaat ccttaaagtt tccccaggtg attccaggtt tggtcaccat     3360

tatcttagag catctactca cttcctctag ccttggggtt atttgtccaa ggtcttgtag     3420

tgagttacag aatactaaag tggatgtaga agtggtcaga ttgactgaaa ctataccctg     3480

aattagatgt gagtttagat tttgtttata tggaacctga tccaaaaaac tacgaagtcc     3540

tgagcttgtt tcctgtatag tactgatgct gaaataagat gacagcagtt tgtaaaataa     3600

tacacaaata tgaggaattg tctgacattc caaatttcga ggatttttag acttttttca     3660

ttaaacctta gaaaaaaatt accagtaatc ctacaactac tggtagtgtt gttgtgcatt     3720

tgcacaaaat aggtataatt ttttcttatt acatcccaag tttatgatgc attaagcgtt     3780

ttgcatattt tgatatattt ttgctttggt ttaccataca ttttagtggc tacagaatgt     3840

agtctgctta ataaatggga attcctagaa tgtttaaata ccatactatt taagacaaaa     3900

tacaaaatat ccagaaaaat ccaggttgcg tggctggtta gtaaaggact aaaacccagg     3960

ttcttggcta aatgttttcg tttatactgt ttatctttcc cattgcttaa gcacagcaca     4020

aactatgtaa ttatatataa ttacagttga cccttgaaca acatgggttt gaactgtgtg     4080

agtctcctta cacacaggtt ttcttccacc cctgagatgg caagaccagc cccttgtctt     4140

cctcagcctg ctcaacgtga agatgatgag gatgaagacc tttatgatga tccacttcta     4200

cttattaaat agtaaatata tttttttctt atgattttat tttcttttct ctagcttcat     4260

aagaatatag catatgggct gggcgcagtg gctcacgcct gtaatcccag cactttggga     4320

ggctgaggcg ggcggatcac aaggtcagga gattgagacc atcctggcta acacagtgaa     4380

accctgtctc tactaaaaac acaaaaactt agccaggcgt ggtggtacat ggctgtagtc     4440

ccagctactt gggaggctga gacaggagaa tcgcttgaac ctgggaggtg gaggtttcag     4500

tgagccaaga ttgtgccact gcactccagc ctgggtgatg gagcgaggct ctgtctcaaa     4560

aaagaaaaaa aatatatagc atataacata caaaatgagt ttatcaactg tttgttattg     4620

gtaagtcagc agtgggctat tggtggttaa gttttggggg agtcaaaagt tacatgcaaa     4680

ttttttactg tgcggggtgt cagcatccct aaccccatgt tgttcaaggg tcaactgtag     4740

tttaaaatga ctcctgtctc aaaaaaccaa aggataacct ttaagggatt ggtaactttg     4800

actcaaaact gctttgtaat cttttcacaa tgtactgaaa agtgtggcta gttatgtttg     4860

atccacattc tagagaaatt tgtaggtttt aatttctttt ctcttggtcc tctcttcatg     4920

tataatggtt gcttttaaca gctgttcgct gatgtggtcc tgctctgtcc cagtctagca     4980

gctttagtgt atggaaaaat tgaactagga attgagtttt gaagaaataa aggtgtaaga     5040

gcaaacattc aacagttgct gtccccagta atgaagttca tacagacaaa agatggcatg     5100

tcactgtaca tcataccttg caataaatat tctgttaaat tgtgctggtg caatttaaca     5160

tgcttttgtc aaagtaaa                                                   5178


<210> 1950
<211> 2516
<212> DNA
<213> Homo sapiens

<400> 1950
gtgccaggtc agagctgcaa ctctgtgcta cgtttctgtg tggctttctt gaaactactt       60

ctctttattt ttgttggcgt ggctatttat tgttatctgt aacgacgcaa tatgctgccg      120

aagtctggga aggagagggg agctgtaagt ctacaccagt gttaactggc taaccttgga      180

tgcctgtcat ttgatgttgg acatttgaaa gatggcagca tctctgggga aggagggact      240

gaacactttt gaccacctac catgtcccag gttctatcga tcctgggcat gcacacgctc      300

atgagtaacc agcagtacta ccaggccctg agcagcagct ccatcatgaa caaggagggg      360

ctcaacagcg tgattaaacc cacacaatac aagcctgtgc ccgacgaaga accaaattca      420

acagacgtag aggaaacgct ggaacggata aagaacaacg acccaaaact tgaagaagtt      480

aacctcaata atatccggaa tatccccatc cccaccctca aggcatatgc agaagccctg      540

aaagaaaact catatgtgaa gaagttcagc atcgtgggga cacggagtaa tgaccccgtg      600

gcgtatgccc ttgctgagat gctcaaggag aacaaggtgt tgaagacact gaatgtggaa      660

tccaacttca tttctggagc tgggattctg cgcctggtag aagccctccc atacaacact      720

tctctggtgg aaatgaaaat tgacaaccag agccagcccc tgggcaacaa agtggaaatg      780

gagattgtga gcatgttgga aaaaaacgca acacttctca aattcggcta ccactttacc      840

cagcaaggac cccggcttcg ggcatccaac gcaatgatga acaacaatga ccttgtgagg      900

aagaggaggc ttgcggacct gactgggccc atcattccca agtgccggag tggtgtctag      960

tgtgtggcgg tggagtccat gcctttgaac tggatgtgtt ctattgatga cctgtgctct     1020

gcaggggaaa ccagaaggca aaatgctggc agcatgaaac ccttttgtgg ttcagttctt     1080

tatgcactaa ggttttaggt tgactagtgg ttgtagttga aaattttata aaataccgtt     1140

aatgtgaagt ttttctttag tcacagaagt tgaatctggt tattatttaa aaactagaag     1200

cccccaaacc agcagatctt actgaagatg atgttccagc agcagcgact tagccccagg     1260

agcccagttt caatggcctt gctgtgtggt gtttcaagtg catttaaaat gtgtgacaca     1320

gaaacggcac actcttccac atgcttttga agtattataa aacactttat tacaaatttg     1380

tcttagctat tagcaaataa aactgattat cattctttat taaccctcct tggaattttg     1440

aaaacctcga ttaaagttgc caaattgatt actggatcca gaacacaatt ttcccctcag     1500

aacagataga cagactgaag ccactgaact ctgccaggag tcaacatgag attccttttg     1560

ctggatatgc agaaatgata ggaaaaaaac caatggtgaa atttcaagtt tcaaaaacca     1620

acctttcatt accaatccca ggcaacaaac atgtccctga gtgttcttta agaacatttg     1680

ggatttatgt acaatttaat actggagtta gaactttttc cttattgaat gccaacctta     1740

tgatggatgt gaaaatctac ggccaaatac ttttgaaaac acctttctat attgcacagt     1800

gggcaaatgg cttatgtgag gtaagacact agagggataa atttccagat caacatggct     1860

atggtattta gtaatggccc agcttagaga cttcagctac tgatctcatc acttattaga     1920

caaattgctg ctgaccttac gcctgtatat taagcctccg caggatgccg gacaatggtg     1980

aagaaactcc agatatcaag gaattgggaa atcctggcca aaccacccca agatgattac     2040

actgaaatgt agtattagta ctgctgccag atctcttttt aacatcatgt gcgtctcttg     2100

ggatccagca aaagtgttaa gccacaatgc ccttgtgcct tttaatatac cacagtgcca     2160

gttaaactaa tatttttgtt tgttgctttt gggagttatt ttcattagtg atttcagcaa     2220

atctcatgat aaaggacaag gtcaagaact ccagagcact gagcagagag gctggtgatg     2280

aaaaggtgaa ggcctgcgca ctgaactgta aggcagtggg cagtacaggg taactggagg     2340

cggggccagg gcctcagcgc tatggaagag tgtccactga ggctgcacat ggcccaggag     2400

tggcaccatg ttgcagggac aaccatcccc atttggcttc tccttaaaac acaattgcag     2460

ctgcattctg catcgctgaa aactgcaata taatattaaa tctgttggtc tatgca         2516


<210> 1951
<211> 3741
<212> DNA
<213> Homo sapiens

<400> 1951
cctccgcgcc cccggctgct gctcacgccc cgcccgggag ccagattttg tggaagtata       60

atactttgtc attatgagat gtcgtctctc ggtgcctcct ttgtgcaaat taaatttgat      120

gacttgcagt tttttgaaaa ctgcggtgga ggaagttttg ggagtgttta tcgagccaaa      180

tggatatcac aggacaagga ggtggctgta aagaagctcc tcaaaataga gaaagaggca      240

gaaatactca gtgtcctcag tcacagaaac atcatccagt tttatggagt aattcttgaa      300

cctcccaact atggcattgt cacagaatat gcttctctgg gatcactcta tgattacatt      360

aacagtaaca gaagtgagga gatggatatg gatcacatta tgacctgggc cactgatgta      420

gccaaaggaa tgcattattt acatatggag gctcctgtca aggtgattca cagagacctc      480

aagtcaagaa acgttgttat agctgctgat ggagtattga agatctgtga ctttggtgcc      540

tctcggttcc ataaccatac aacacacatg tccttggttg gaactttccc atggatggct      600

ccagaagtta tccagagtct ccctgtgtca gaaacttgtg acacatattc ctatggtgtg      660

gttctctggg agatgctaac aagggaggtc ccctttaaag gtttggaagg attacaagta      720

gcttggcttg tagtggaaaa aaacgagaga ttaaccattc caagcagttg ccccagaagt      780

tttgctgaac tgttacatca gtgttgggaa gctgatgcca agaaacggcc atcattcaag      840

caaatcattt caatcctgga gtccatgtca aatgacacga gccttcctga caagtgtaac      900

tcattcctac acaacaaggc ggagtggagg tgcgaaattg aggcaactct tgagaggcta      960

aagaaactag agcgtgatct cagctttaag gagcaggagc ttaaagaacg agaaagacgt     1020

ttaaagatgt gggagcaaaa gctgacagag cagtccaaca ccccgctgct gccttccttt     1080

gagattggtg catggacgga agacgatgtg tattgttggg ttcagcagct cgtcagaaaa     1140

ggtgactctt cagcagagat gagtgtatat gcaagcttgt ttaaagaaaa caacattaca     1200

gggaagcggc tgctgctgct ggaggaagaa gacctgaaag acatgggcat tgtctccaag     1260

gggcatatca ttcacttcaa gtcagccatt gagaaattaa cccatgatta cataaatttg     1320

tttcacttcc caccactaat taaggactca ggaggtgaac ctgaagaaaa tgaggaaaaa     1380

atagtgaacc tggaactggt ttttggtttt cacttgaaac caggaactgg cccacaggat     1440

tgtaagtgga aaatgtatat ggagatggat ggggatgaaa ttgcaataac ctacataaaa     1500

gatgtgacat tcaacactaa cctacctgat gcggagattt taaagatgac aaagccacca     1560

tttgtaatgg agaagtggat tgtaggaata gcaaaaagtc agactgtgga gtgcactgtc     1620

acatatgaga gtgatgttag aactccaaaa agcactaaac atgtccattc gattcagtgg     1680

agtagaacaa aacctcagga tgaagtgaaa gcagtccaac ttgccattca gacattattc     1740

accaattcag atggcaaccc tggaagcagg tccgactcaa gtgctgattg ccagtggtta     1800

gatactctga ggatgcggca gattgcatcc aacacttctt tacagcgttc ccagagcaat     1860

cctattctgg ggtcaccgtt cttctcacac tttgatggcc aggattccta cgctgctgct     1920

gtgagacggc cccaggtgcc cattaagtat caacagatta cacctgtgaa ccagtccaga     1980

agctcgtctc ctactcagta tggactgacc aaaaacttct cttccctaca tctcaactct     2040

agggacagtg gcttttccag tggcaatact gacacctctt cagagagggg tcgatactca     2100

gacagaagca ggaacaaata tggacgtggt agtatatcac tcaattcttc tcctagagga     2160

agatacagtg gaaagagtca gcattccact ccttcaagag gaagataccc tggaaagttc     2220

tacagggttt ctcagtcagc actcaatcct caccagtcgc ctgacttcaa gagaagcccc     2280

agggacctcc accaacccaa caccatacca gggatgcctt tgcaccctga gactgactca     2340

agagccagtg aagaggacag caaagtcagc gaagggggct ggacaaaagt ggaataccgg     2400

aaaaagcccc acaggccatc tcccgccaaa accaataaag agagagccag aggggaccac     2460

cgtggatgga gaaacttttg atgaattgaa ctacatagct tttctaagca ggttaaaaaa     2520

aaaaaaaaaa agaaatgtaa tggtttttga taatatgatc ccttcagatt gaattaacga     2580

aaagacaaca cttccagttt ttggattggg aaataccttc taattgagac tatagccaaa     2640

ccagggccaa aattatggat attggtcacc cagtgatcat aactaggctt gaaaatcact     2700

acacatattt tctgccttga gtgaacattt ttagaggaaa ggttatgcca tctttttacc     2760

ctaaccactg atattctggt tagcagggcc aggacaaggg gaaggaaaat gaggtcaaca     2820

aaaaaatcaa atttttagga aaagataaga tgaatgttac tgatttttcc ttttggctga     2880

ggctgcaata tggcctggca aggcactgtt actgatcttg tctttaacat tttgatattt     2940

tgttcatcat aatttttgca tttatttttt taaatattgc attaaaatat catttagctt     3000

gattatcgag ttttttggtt tgaggttttt tgttgcttct tttttctttt ctttctttcc     3060

ccctcttttt tttggatgtc cccttaaatt ttgtgcccaa ggcaggtacc tcactcatct     3120

catccttggc tcagccctgc tggttagtat ttagtattta ttttagtaag atatttgtgt     3180

ctgtatgatg gtcagagttg aactgatctg gcttgtcatt tttcagtaat aaaaaaagtt     3240

actgaattta atgttgaata tgatgcatat ctcattcatt acgatttatc agaaaccaaa     3300

gatttaaatt gcctagattt gtggttcttt ctcttcctaa gttcccagcg actgctttca     3360

aatactattt tctaaatttc accaaaggag caaagaggat aaaacaacac tccataaagg     3420

cctcttggga tgtcagaaat ctaaaatcta aaagaaaaca gacacagagc aagacaataa     3480

catcacaagc taaaagccag agaaatttaa aattaccaac atccttgttg gagtaagaca     3540

gtaaatatca gccttgcagc aagacagctc tgagcagctg tgggcaaaga ggtaaaccag     3600

tgggggtgca aggagactgt ctgcagctta gggcagaaat ggtgggatcc aacttgtgaa     3660

atgcttcatg ttttacaaac caaaaagtca ggtagcaaca aacttattgt atgtcaaatc     3720

aataaatgtt actttcaata t                                               3741


<210> 1952
<211> 1406
<212> DNA
<213> Homo sapiens

<400> 1952
ggaggtgagc aggaaggaga cggccgccca gcagcccgtg ggcaggcgcg gcggagcgag       60

cggggccggc ggcgggcgcc gagggacgcc gaggcctcgg gcgggggctg gcccggggtt      120

ccaggtctcc agtgggggct gcagactaag caaaatgagg cggttcctga ggccagggca      180

tgaccctgtg cgggagaggc tcaagcggga cctgttccag tttaacaaga cggtggagca      240

tggcttcccg caccagccca gcgccctcgg ctacagcccg tccctgcgca tcctggccat      300

cggcacccgt tctggagcca tcaagctcta cggagcccca ggcgtggagt tcatggggct      360

gcaccaggag aacaacgctg tgacgcagat ccacctcctg cccggccagt gccagctggt      420

caccctgctg gatgacaaca gcctgcacct ttggagcctg aaggtcaagg gcggggcatc      480

ggagctgcag gaggatgaga gcttcacact gcgtggaccc ccaggggctg cccccagtgc      540

cacacagatc accgtggtcc tgccacattc ctcctgcgag ctgctctacc tgggcaccga      600

gagtggcaac gtgtttgtgg tgcagctgcc agcttttcgt gcgctggagg accggaccat      660

cagctcggac gcggtgctgc agcggttgcc agaggaggcc cgccaccggc gtgtgttcga      720

gatggtggag gcactgcagg agcaccctcg agaccccaac cagatcctga tcggctacag      780

ccgaggcctc gttgtcatct gggacctaca gggcagccgc gtgctctacc acttcctcag      840

cagccagcaa ctggagaaca tctggtggca gcgggacggc cgcctgctcg tcagctgtca      900

ctctgacggc agctactgcc agtggcccgt gtccagcgaa gcccagcaac cagagcccct      960

ccgcagcctc gtgccttacg gtccctttcc ttgcaaagcg attaccagaa tcctctggct     1020

gaccactagg caggggttgc ccttcaccat cttccagggt ggcatgccac gggccagcta     1080

cggggaccgc cactgcatct cagtgatcca cgatggccag cagacggcct tcgacttcac     1140

ctcccgtgtc atcggcttca ctgtcctcac agaggcagac cctgcagcca gtaggagagc     1200

ttcgggagtg ggtgcccagg gttaggtgtg ggaggcatgg ggcaggacca tcagtaaaga     1260

cagggccagg tgcagtggct cctgcctgta accccagtgc tgtgggaggc caaggtggta     1320

ggatcgcttg aacccaggag ttcaagtcca gcctggacaa cgtagggaga cccttgtctc     1380

tacaaaaaat aaaaaaatta gccagg                                          1406


<210> 1953
<211> 2526
<212> DNA
<213> Homo sapiens

<400> 1953
atgggagcca gagctgctgg aacatcctca ggaggtggcc ctcgcccctg cttggcaaga       60

ggcctctcag caagcccatt tccagccaag cagcagcacc ctcaggcagg ggctagtcca      120

gcagagctcc agcagagggc ttactacaga gccaggcaag atgcagcatc tcaaccaggc      180

cttgggttcc tcattagccc cagttcatgt tcctcttggg ggcctggctc ctttacgagg      240

tcttgtggat accccaccct ctgctcttcg tggatctcaa agcgtgagcc tggggagctc      300

agtggagtct ggacgtcagc ttggagaact catgctgcct tcacagggtc tcaagacctc      360

tgcttataca aagggttggg ctccatatat gaggacaaga ctgctctcag cctcttgggt      420

ttaggagaag aaaccaatga ggaggatgag gaggaaagtg acaaccagag tgtccacagc      480

tcaagtgagc ctcttaggaa cctacacctg gacattgggg cactgggggg tgactttgag      540

tatgaggagt ctctgagaac aagccagcca gaggagaaga aggatgtttc tctggattca      600

gatgctgccg gtccccctac tccctgcaag ccctccagcc caggtgcaga cagcagtctg      660

agcagtgctg ttggcaaagg gcgacaggga agtggagcaa gacctggtct tccagaaaaa      720

gaggaaaatg agaagagtga acctaagatt tgcaggaatc tggtgacccc caaggcagac      780

cctacaggca gtgagcctgc caaagcctct gaaaaggaag caccagagga cacagtagat      840

gcaggagagg agggttccag gagggaagag gcagccaagg agccaaagaa gaaggcttct      900

gctctggaag agggcagttc agacgccagc caagaactgg aaattagtga acacatgaag      960

gaaccacagc tctcagactc catagcttct gaccccaagt ccttccatgg cctggacttc     1020

ggttttcgca gccggatctc ggagcacctg ctggatgttg atgtgctttc cccagtcctg     1080

ggtggagctt gtcggcaggc ccagcaacca ctgggaatag aagacaagga tgacagccag     1140

tccagccaag atgagctgca gagcaagcag tccaaaggcc tggaggagag gtaccatagg     1200

ttatctcctc cacttccaca cgaggagcgg gcccagagtc cccctcgcag cctggccact     1260

gaagaagagc ctccccaggg ccccgagggg cagcccgagt ggaaggaggc agaggagctt     1320

ggggaggact ctgcagccag cctcagcctg cagctgtccc tccagaggcg atccacagag     1380

cctgtggctc ccccagagca gctctcagag gctgcactaa aggccatgga agaggcagtg     1440

gcccaagtac tcgagcaaga ccagaggcac ctgctggaat ccaagcaaga gaagatgcag     1500

caactgcggg agaagctgtg ccaagaggag gaagaggaga tcctccggct tcaccagcag     1560

aaagagcaat ctctcagttc cttgagggag cggctgcaga aagccattga ggaggaggag     1620

gcccggatga gagaggagga aagccagagg ctatcctggc tccgagctca ggtccagtcc     1680

agcacacaag cagatgagga ccaaatcagg gctgagcaag aggcttccct gcagaaactg     1740

agagaagagt tggagtctca acagaaggct gagagggcca gcttggaaca gaaaaatagg     1800

caaatgctgg agcagctcaa ggaagagata gaggcttcgg agaagagcga gcaggctgcc     1860

ctgaatgctg caaaggagaa ggctctgcag cagctgaggg agcagctgga aggggagagg     1920

aaagaagctg tggcaacgct ggagaaggag cacagtgctg agctggagcg gctctgctcc     1980

tcattggagg ccaagcaccg ggaggtggtc tccagcctcc agaagaagat acaggaagct     2040

caacagaaag aggaggccca gctgcagaag tgccttgggc aagtggagca cagagttcac     2100

cagaagtctt atcacgtggc tgggtatgag cacgagctca gcagtctcct gcgagagaag     2160

cgccaggaag tggaagggga gcatgagagg aggttggaca agatgaagga ggagcaccag     2220

caagtgatgg ctaaggccag agagcagtat gaagctgagg agaggaagca gcgggctgag     2280

cttctggggc acctgaccgg agagctggag cgcctgcaga gggcccatga acgagaactg     2340

gagactgtga ggcaggagca acacaagcgt cttgaggact tgcggcgccg gcacagggag     2400

caggaaagga agctccagga tttagagttg gaccttgaaa ccagagctaa agatgtcaag     2460

gccagattgg ctctgctgga ggtccaggtg agggatctgc aggagtcctt gacctcagag     2520

tcatag                                                                2526


<210> 1954
<211> 3646
<212> DNA
<213> Homo sapiens

<400> 1954
gcgtcctgct ttcctgtcac cgcaagggcc gggccgcccg ctgcttccca cccctgcagc       60

ctgcgctgcg gagtacaaag agcggagggc gcgcttgacc tggggctggg gtccagccct      120

gcccgccggt gccgtctgct caactagtta ggtggctgct gcgcaggatt ccgggaaacg      180

tcagtctgcc atgagccggc aggactgagc ctgcgactcg gagcagagcg agtgaggggc      240

agagcggtgc tcaggagtgc ggcccggggc cgccggagct gggggtcggg ccgggcgatg      300

atccggggct tcgaggcgcc catggcggag aacccgccgc cgccgccgcc gcccgtcatc      360

ttctgccacg actccccgaa gcgggtgctg gtgtcggtca tcaggacgac cccgatcaag      420

ccaacgtgcg gcggtggagg ggagccggag ccgccgccgc cgctcatccc caccagcccc      480

ggcttcagcg acttcatggt gtacccgtgg cgctggggcg agaacgcaca caacgtgacg      540

ctcagccctg gggccgcggg ggccgccgcc tcggccgccc tgcctgcagc cgcagccgcc      600

gagcactcgg ggcttcgtgg ccggggcgcg cccccgcccg ccgcctcggc ctccgccgcc      660

gcctcgggag gtgaggacga ggaggaagcg agcagcccag acagcggcca cctcaaggat      720

ggaatccgac gtggtaggcc cagagcagat actgtccgcg atttaataaa tgaaggagag      780

cattcatcca gcagaatccg ttgtaacatc tgtaataggg tgtttccacg ggagaaatcg      840

ctccaggctc acaaaaggac tcatacaggt gagaggccct atctgtgtga ctatccagac      900

tgtggaaaag cctttgttca aagtggacag ctcaaaacac atcagcgtct tcacaccgga      960

gagaaacctt ttgtttgttc agaaaatggc tgcctgagca gattcaccca tgcaaaccgc     1020

cactgtccga agcaccccta cgccaggctg aagagagagg agcccacgga cacactcagc     1080

aaacatcagg ctgccgacaa caaggccgcg gccgagtggc tggcgaggta ttgggaaatg     1140

agagagcagc gcacccccac tttgaaaggc aagctggttc agaaggctga tcaggagcag     1200

caggaccctc tggaatacct tcagtctgat gaagaggacg acgagaagag aggggcccag     1260

cgccggctgc aggagcagcg ggagcgcctg catggagccc tcgcgctcat agagcttgcc     1320

aacctgactg gggcgccact ccgacagtag cttggacact gactcttcca ctgtacaaaa     1380

gtactgccca gcatacttaa aaagtagatc cttgggcata agctaagcac cttatttgct     1440

tatcataggc tgctattctg tagaaattta tgaagaatgt tattgcccca gaatatgggg     1500

tgagagagaa ctgcactttt ttaatatgga aatgaattca tcgtaaagtt taaaatattt     1560

tgtaaatatg gactgcacag tacagggtag aaaactacat attgtgggaa gctagatttt     1620

gcaagtttaa tgcattcatt ggaagcagtt ctcacaggaa gcactttctg aataagacac     1680

ttgtttgaaa aacagaatgg tacaaatagc caaagaagat taaaacagat tatttataag     1740

atcattttta acaatatata ttagtatgtt taacaatact gtaaacactg aagcaagcaa     1800

gaaagtataa aatatgtaag atagataatt ttaattgcaa aatactgtgc ccactaaggc     1860

tagagaaatg ggaggctatt ttggaagatg ttctaagtaa tggacttaga agaaaataga     1920

tatttgaggc tcttggtaag atgcacaata gttcagaatt tttgaaattg gagcaaaatc     1980

agtcttattc tatctggggc tttacaactc agtataatgt ttaagtttga aaagcacttg     2040

tcatccctag catgttaact tgggaacttt tgcacatttc atatttctca tttgctgaaa     2100

ttgagtgatt aatcttgcaa agtctaggta acatagtaat tggtaatttt aaaaatacat     2160

attaagggcc ctgtaatgag atttggcact tggattttta ctaaagggac acctgcaggg     2220

ttgttttgta gtgaaatgtt ttagatcttt tgttagcaaa cactacattt taattgtact     2280

gcttgtttag aattattagc aaatggaagc ctccatattt atattttcag tgcataaagc     2340

caccttcttg ctttacttca gagtaacatg ccaagctatt ttgtgttcac taaatttagc     2400

tatcagttaa acactgcaga aaatattagc tactcaaata agtaggcttc tgaaatagtt     2460

ttaactgcaa gtgtgttaac ttgtgtggtg gtttgaagcc atttttccaa ataaagttat     2520

taaacaccac tttatgtact gaagcatgaa cagaaaaatc aagagctgag cagaccacct     2580

cctttatgta ggcaaaactt ccatcatttt ggcttttgtt ctaaacagaa ctaaatgaca     2640

tgcatagcat ggtaacttac agatcgctta attggagtaa aactcagagt aatagaggga     2700

aatatgggct cttcagtgcc tttttagctt ttttgagttg aagacgttcc tacagatgta     2760

gtttaaacat tacaaagtag gcttctttat ccaaaaatcc caatgtgtca tagtacacag     2820

atagtttaaa atatgtagcc acggggaagg ggaggcatgt aaatgtcttg aagaggagaa     2880

aaagtatgaa agaagatacg atagttacga ataatgtgta tgatgaggac atactttaaa     2940

aatgtaattc ctctgtacag taaattacaa atctttaggg atttttttgt aataagagaa     3000

tttatatttg taatggtcta agaatttttt tgtaatgtgg tatatagaat tttaatttgg     3060

agcacttata agctggtaag agagactata gcatctgaat tatcttggtt tatgtttcag     3120

catttcctct agaatttttg ctctcaaata tgtgatttaa tgaactaaaa acaacactca     3180

tcagtcttgg gaaatttgaa ctttgatcaa cttaactaaa gaaggaaggg tagtaagaat     3240

ttttcaaata caaatatttg ccaattcaca gatgataaca tttaaggcct tcaaaagtaa     3300

gggtttttcc ttgtttctcc agtcagcttt tgtcaactct aatagttttt tcataaacat     3360

tttttatttg tataattgca acagtttaag aaattatcac aactatttag aaacatttaa     3420

aatgttcttt ttgatataag ctatatactt ggaaaaatac attggtatct aaaatttgag     3480

gtgtgttaag actgcttttt gttttaaaaa atggtttaca ttcaaatttt tgaagtgttt     3540

tatgcttcat atggctaagt tgtagtttgg cagagttaac agcataagaa taaacatgct     3600

gtaattttaa aagatgcttt gaataaaaat ttattttaat ttaaaa                    3646


<210> 1955
<211> 1825
<212> DNA
<213> Homo sapiens

<400> 1955
gctgggcaga gccctggggg cgcggtgctg ccgcctccag gtctccgccc cgtgtgtgcg       60

ccctgcactt agggatccct ccctcactgc cccggtactc acaagcttct cggccccgac      120

cttcgccctg ggaggttctg gccaggtgcc gggaggggcg ctgtgtcgag ggcgatcccc      180

ccaaagcagc gtcccgtgct aaaggtactg cttaggatga atatgatttg gagaaattcc      240

atttcttgtc taaggctagg aaaggtgcca cacagatacc aaagtggtta ccacccagtg      300

gcccctctgg gatcaaggat tttaactgac ccagccaaag tttttgaaca caacatgtgg      360

gatcacatgc agtggtctaa ggaagaagaa gcagcagcca gaaaaaaagt aaaagaaaac      420

tcagctgtgc gagtccttct ggaagagcaa gttaagtatg agagagaagc tagtaaatac      480

tgggacacat tttacaagat tcataagaat aagtttttca aggatcgtaa ttggctgttg      540

agggaatttc ctgaaattct tccagttgat caaaaacctg aagagaaggc gagagaatca      600

tcatgggatc atgtaaaaac tagtgctaca aatcgtttct caagaatgca ctgtcctact      660

gtgcctgatg aaaaaaatca ttatgagaaa agttctggtt cttcagaagg tcaaagcaaa      720

acagaatctg atttttccaa cctagactct gaaaaacaca aaaaaggacc tatggagact      780

ggattgtttc ctggtagcaa tgccactttc aggatactag aggttggttg tggagctgga      840

aatagtgtgt ttccaatttt gaacactttg gagaactctc cggagtcctt tctgtattgt      900

tgtgattttg cttctggagc tgtggagctc gtaaagtcac actcgtccta cagagcaacc      960

cagtgttttg cctttgttca tgatgtatgt gatgatggct taccttaccc ttttccagat     1020

gggatcctgg atgtcattct ccttgtcttt gtgctctctt ctattcatcc tgacaggatg     1080

caaggtgttg taaaccgact gtccaagtta ctgaaacctg ggggaatgct gttatttcga     1140

gactatggaa gatatgataa gactcagctt cgttttaaaa agggacattg tttatctgaa     1200

aatttttatg ttcgaggaga tggtaccaga gcatatttct ttacaaaagg ggaagtccac     1260

agtatgttct gcaaagccag tttagatgaa aagcaaaatc tggttgatcg ccgcttacaa     1320

gttaatagga aaaaacaagt gaaaatgcac tgagtgtgga ttcaaggcaa attccagaaa     1380

ccattgcacc agactcagaa tagctccaat atggtatcta cactcctttc acaagactga     1440

actttgtaac atgttaaggt acaaagccag aggactgtgc tattcaagga ctactgtaag     1500

tctattgttt ctcaaaagac aatgagaaaa aaagaagaga atttgtattt cctgccgttt     1560

tgtcataggt gagctccttt gtgcatttta agcacatgta agtggttcag cacagtatgc     1620

ctttttctgt gctttgaaaa cttgatatgc tcaagcttgt ttgaatttat tacatctaac     1680

cattttgctt gttccttgat ttttataagc attcaattaa gttagtatta tgtcaagtaa     1740

ttttgagaaa atgtaacttg acattttttg caagtaaaaa aaattgttta tttgtttagg     1800

cttagtaaac cagttcccaa acaca                                           1825


<210> 1956
<211> 5777
<212> DNA
<213> Homo sapiens

<400> 1956
cagccgcgtc ccccagcccc ggcctcccgc ggacccatgc ccgcccgtat cggctactac       60

gagatcgacc gcaccatcgg caagggcaac ttcgcggtgg tcaagcgggc cacgcacctc      120

gtcaccaagg ccaaggttgc tatcaagatc atagataaga cccagctgga tgaagaaaac      180

ttgaagaaga ttttccggga agttcaaatt atgaagatgc tttgccaccc ccatatcatc      240

aggctctacc aggttatgga gacagaacgg atgatttatc tggtgacaga atatgctagt      300

ggaggggaaa tatttgacca cctggtggcc catggtagaa tggcagaaaa ggaggcacgt      360

cggaagttca aacagatcgt cacagctgtc tatttttgtc actgtcggaa cattgttcat      420

cgtgatttaa aagctgaaaa tttacttctg gatgccaatc tgaatatcaa aatagcagat      480

tttggtttca gtaacctctt cactcctggg cagctgctga agacctggtg tggcagccct      540

ccctatgctg cacctgaact ctttgaagga aaagaatatg atgggcccaa agtggacatc      600

tggagccttg gagttgtcct ctacgtgctt gtgtgcggtg ccctgccatt tgatggaagc      660

acactgcaga atctgcgggc ccgcgtgctg agtggaaagt tccgcatccc attttttatg      720

tccacagaat gtgagcattt gatccgccat atgttggtgt tagatcccaa taagcgcctc      780

tccatggagc agatctgcaa gcacaagtgg atgaagctag gggacgccga tcccaacttt      840

gacaggttaa tagctgaatg ccaacaacta aaggaagaaa gacaggtgga ccccctgaat      900

gaggatgtcc tcttggccat ggaggacatg ggactggaca aagaacagac actgcagtca      960

ttaagatcag atgcctatga tcactatagt gcaatctaca gcctgctgtg tgatcgacat     1020

aagagacata aaaccctgcg tctcggagca cttcctagca tgccccgagc cctggccttt     1080

caagcaccag tcaatatcca ggcggagcag gcaggtactg ctatgaacat cagcgttccc     1140

caggtgcagc tgatcaaccc agagaaccaa attgtggagc cggatgggac actgaatttg     1200

gacagtgatg agggtgaaga gccttcccct gaagcattgg tgcgctattt gtcaatgagg     1260

aggcacacag tgggtgtggc tgacccacgc acggaagtta tggaagatct gcagaagctc     1320

ctacctggct ttcctggagt caacccccag gctccattcc tgcaggtggc ccctaatgtg     1380

aacttcatgc acaacctgtt gcctatgcaa aacttgcaac caaccgggca acttgagtac     1440

aaggagcagt ctctcctaca gccgcccacg ctacagctgt tgaatggaat gggccccctt     1500

ggccggaggg catcagatgg aggagccaac atccaactgc atgcccagca gctgctgaag     1560

cgcccacggg gaccctctcc gcttgtcacc atgacaccag cagtgccagc agttacccct     1620

gtggacgagg agagctcaga cggggagcca gaccaggaag ctgtgcagag ctctacctac     1680

aaggactcca acactctgca cctccctacg gagcgtttct cccctgtgcg ccggttctca     1740

gatggggctg cgagcatcca ggccttcaaa gctcacctgg aaaaaatggg caacaacagc     1800

agcatcaaac agctgcagca ggagtgtgag cagctgcaga agatgtacgg ggggcagatt     1860

gatgaaagaa ccctggagaa gacccagcag cagcatatgt tataccagca ggagcagcac     1920

catcaaattc tccagcaaca aattcaagac tctatctgtc ctcctcagcc atctccacct     1980

cttcaggctg catgtgaaaa tcagccagcc ctccttaccc atcagctcca gaggggctgc     2040

atcttcttcc cagtttcaag gcttaccttc ccgcagtgca atctttcagc agcaacctga     2100

gaactgttcc tctcctccca acgtggcact aacctgcttg ggtatgcagc agcctgctca     2160

gtcacagcag gtcaccatcc aagtccaaga gcctgttgac atgctcagca acatgccagg     2220

cacagctgca ggctccagtg ggcgcggcat ctccatcagc cccagtgctg gtcagatgca     2280

gatgcagcac cgtaccaacc tgatggccac cctcagctat gggcaccgtc ccttgtccaa     2340

gcagctgagt gctgacagtg cagaggctca cagtgcacat cagcagccgc cacactatac     2400

cacgtcggca ctacagcagg ccctgctgtc tcccacgccg ccagactata caagacacca     2460

gcaggtaccc cacatccttc aaggactgct ttctccccgg cattcgctca ccggccactc     2520

ggacatccgg ctgcccccaa cagagtttgc acagctcatt aaaaggcagc agcaacaacg     2580

gcagcagcag cagcaacagc agcaacagca agaataccag gaactgttca ggcacatgaa     2640

ccaaggggat gcggggagtc tggctcccag ccttggggga cagagcatga cagagcgcca     2700

ggctttatct tatcaaaatg ctgactctta tcaccatcac accagccccc agcatctgct     2760

acaaatcagg gcacaagaat gtgtctcaca ggcttcctca cccaccccgc cccacgggta     2820

tgctcaccag ccggcactga tgcattcaga gagcatggag gaggactgct cgtgtgaggg     2880

ggccaaggat ggcttccaag acagtaagag ttcaagtaca ttgaccaaag gttgccatga     2940

cagccctctg ctcttgagta ccggtggacc tggggaccct gaatctttgc taggaactgt     3000

gagtcatgcc caagaattgg ggatacatcc ctatggtcat cagccaactg ctgcattcag     3060

taaaaataag gtgcccagca gagagcctgt catagggaac tgcatggata gaagttctcc     3120

aggacaagca gtggagctgc cggatcacaa tgggctcggg tacccagcac gcccctccgt     3180

ccatgagcac cacaggcccc gggccctcca gagacaccac acgatccaga acagcgacga     3240

tgcttatgta cagctggata acttgccagg aatgagtctc gtggctggga aagcacttag     3300

ctctgcccgg atgtcggatg cagttctcag tcagtcttcg ctcatgggca gccagcagtt     3360

tcaggatggg gaaaatgagg aatgtggggc aagcctggga ggtcatgagc acccagacct     3420

gagtgatggc agccagcatt taaactcctc ttgctatcca tctacgtgta ttacagacat     3480

tctgctcagc tacaagcacc ccgaagtctc cttcagcatg gagcaggcag gcgtgtaaca     3540

agaaacagag agttttgtgt acagcttggg aatgaaaagg ttgattgtaa acccacagta     3600

tctagcagcg ttgtgccaaa ttgcccttgt gtttctctcc acccaaaata tcacagctgc     3660

tttcctcaca tttggttcat ccgtgtgctg ttcttttggg ttctgagagg gttttgccat     3720

gtttgcttgt atgaccaagt caccaaggaa ataaacagga aggaaatcca tgttctccat     3780

cttttgtgaa agtatatttg agttggtggt tttttgtttt gtttgggggt ttgtgttttg     3840

ttttgttttt ggtatgtttt cttccagagg tgatatactt tctttttttt cttcctttct     3900

tttttttctt tcgttccttt tttgaaacag gagagcaaag cagttagagt tcagaggcca     3960

gcggcctcag ggccactccc tccctagcct tcatcagcag agcaccctcc atccccctgc     4020

attgctcttc tgtgaaagca aatactaaag gatgccatcc tctggaatcc taatggcagg     4080

caaagggaga gaggaagggt gacggcttct ggcacttaga aaacaaaaag aacaaaaaaa     4140

gagaaacccc caagcctgga acgcagagag gtctttactg ctgggatcca cggaaaacat     4200

gtctgtccta gccaagatca tatgaagagt ttggcacgga ggctgagaat gacctggcat     4260

agatggtttg ccagttagga tgtctcaatt tgagcctttg cttttggtgg ataactcagc     4320

tcccctcttg taacctggaa agttggttgc ctttatcatc ctgctggttt tatccatgga     4380

ctgaacaccc aacagcagtg cactatgctt tctatggcat ctttcattct cattttatat     4440

tgtgctataa aaaggattgt ttctccatat atatattata tatgtgtgta tatatataat     4500

ataatatatg tgtatatata tattatatat ataatatata atataatata ttatatatat     4560

attatatata taatatatat ataaaatata tatatatatg ctctcctctt tcagcctctt     4620

tgtcacaggg aagaagtgta ggaggttgcc ttgggccctg cctctctcct aacctcctct     4680

tccccactgg gtaccctcag cccctatatt ttaattcttg atcatgtaga aattgttttt     4740

ggtaaatgtt gatattattg ttattatcat tattaataaa taaagagaaa aggaattttt     4800

gtttaaatga gaaatgttta accagattct gttctatttg aattgtgact tgcacctttt     4860

gttcaaagta tttcctttag gcattgtaat tgtgaacagc tcttacttgt gccagtgaca     4920

gatgcagtgg tctcctttcc ccagttgaag cagtgcatac gcagtagcta ttatttgtgt     4980

tatctttatt tctcttcatt gttagaaacc aaagtcttct ctgctggctg gggctgagag     5040

agggtctggg ttatctcctt ctgatcttca aaacaagaga gagaccttga atacactgac     5100

tcttccaccc tttttttttc tgggaaagga gagcaagagg tcccgagtcc cctcctagtc     5160

tttcatcctg aatttgcaca gaggaaagcg ggtgcccggc atggccatcc tgatgttgct     5220

ggcgggatcc ccatgcacct tgtccttctc cactgatact ggcagctcgg ctcctggacc     5280

caagatccct tgagtggaat tctgcagtgc aagagccctt cgtgggagct gtcccatgtt     5340

tccatggtcc ccagtctccc ctccacttgg tggggtcacc aactactcac cagaaggggg     5400

cttaccaaga aagccctaaa aagctgttga cttatctgcg cttgttccaa ctcttatgcc     5460

cccaacctgc cctaccacca ccacgcgctc agcctgatgt gtttacatgg tactgtatgt     5520

atgggagagc agactgcacc ctccagcaac aacagatgaa agccagtgag cctactaacc     5580

gtgccatctt gcaaactaca ctttaaaaaa aactcattgc tttgtattgt agtaaccaat     5640

atgtgcagta tacgttgaat gtatatgaac atactttcct atttctgttc tttgaaaatg     5700

tcagaaatat ttttttcttt ctcattttat gttgaactaa aaaggattaa aaaaaaaatc     5760

tccagactca agttgct                                                    5777


<210> 1957
<211> 6213
<212> DNA
<213> Homo sapiens

<400> 1957
aacaagatgg cggcggcggc ggcgagcgga gctggcgggg ctgccggggc cgggactggg       60

ggagccgggc ccgcgggccg cctgctgcct ccgcccgcgc cggggtcccc agccgccccc      120

gctgccgtgt cccctgcggc cggccagccg cgtcccccag ccccggcctc ccgcggaccc      180

atgcccgccc gtatcggcta ctacgagatc gaccgcacca tcggcaaggg caacttcgcg      240

gtggtcaagc gggccacgca cctcgtcacc aaggccaagg ttgctatcaa gatcatagat      300

aagacccagc tggatgaaga aaacttgaag aagattttcc gggaagttca aattatgaag      360

atgctttgcc acccccatat catcaggctc taccaggtta tggagacaga acggatgatt      420

tatctggtga cagaatatgc tagtggaggg gaaatatttg accacctggt ggcccatggt      480

agaatggcag aaaaggaggc acgtcggaag ttcaaacaga tcgtcacagc tgtctatttt      540

tgtcactgtc ggaacattgt tcatcgtgat ttaaaagctg aaaatttact tctggatgcc      600

aatctgaata tcaaaatagc agattttggt ttcagtaacc tcttcactcc tgggcagctg      660

ctgaagacct ggtgtggcag ccctccctat gctgcacctg aactctttga aggaaaagaa      720

tatgatgggc ccaaagtgga catctggagc cttggagttg tcctctacgt gcttgtgtgc      780

ggtgccctgc catttgatgg aagcacactg cagaatctgc gggcccgcgt gctgagtgga      840

aagttccgca tcccattttt tatgtccaca gaatgtgagc atttgatccg ccatatgttg      900

gtgttagatc ccaataagcg cctctccatg gagcagatct gcaagcacaa gtggatgaag      960

ctaggggacg ccgatcccaa ctttgacagg ttaatagctg aatgccaaca actaaaggaa     1020

gaaagacagg tggaccccct gaatgaggat gtcctcttgg ccatggagga catgggactg     1080

gacaaagaac agacactgca gtcattaaga tcagatgcct atgatcacta tagtgcaatc     1140

tacagcctgc tgtgtgatcg acataagaga cataaaaccc tgcgtctcgg agcacttcct     1200

agcatgcccc gagccctggc ctttcaagca ccagtcaata tccaggcgga gcaggcaggt     1260

actgctatga acatcagcgt tccccaggtg cagctgatca acccagagaa ccaaattgtg     1320

gagccggatg ggacactgaa tttggacagt gatgagggtg aagagccttc ccctgaagca     1380

ttggtgcgct atttgtcaat gaggaggcac acagtgggtg tggctgaccc acgcacggaa     1440

gttatggaag atctgcagaa gctcctacct ggctttcctg gagtcaaccc ccaggctcca     1500

ttcctgcagg tggcccctaa tgtgaacttc atgcacaacc tgttgcctat gcaaaacttg     1560

caaccaaccg ggcaacttga gtacaaggag cagtctctcc tacagccgcc cacgctacag     1620

ctgttgaatg gaatgggccc ccttggccgg agggcatcag atggaggagc caacatccaa     1680

ctgcatgccc agcagctgct gaagcgccca cggggaccct ctccgcttgt caccatgaca     1740

ccagcagtgc cagcagttac ccctgtggac gaggagagct cagacgggga gccagaccag     1800

gaagctgtgc agagctctac ctacaaggac tccaacactc tgcacctccc tacggagcgt     1860

ttctcccctg tgcgccggtt ctcagatggg gctgcgagca tccaggcctt caaagctcac     1920

ctggaaaaaa tgggcaacaa cagcagcatc aaacagctgc agcaggagtg tgagcagctg     1980

cagaagatgt acggggggca gattgatgaa agaaccctgg agaagaccca gcagcagcat     2040

atgttatacc agcaggagca gcaccatcaa attctccagc aacaaattca agactctatc     2100

tgtcctcctc agccatctcc acctcttcag gctgcatgtg aaaatcagcc agccctcctt     2160

acccatcagc tccagaggtt aaggattcag ccttcaagcc caccccccaa ccaccccaac     2220

aaccatctct tcaggcagcc cagtaatagt cctcccccca tgagcagtgc catgatccag     2280

cctcacgggg ctgcatcttc ttcccagttt caaggcttac cttcccgcag tgcaatcttt     2340

cagcagcaac ctgagaactg ttcctctcct cccaacgtgg cactaacctg cttgggtatg     2400

cagcagcctg ctcagtcaca gcaggtcacc atccaagtcc aagagcctgt tgacatgctc     2460

agcaacatgc caggcacagc tgcaggctcc agtgggcgcg gcatctccat cagccccagt     2520

gctggtcaga tgcagatgca gcaccgtacc aacctgatgg ccaccctcag ctatgggcac     2580

cgtcccttgt ccaagcagct gagtgctgac agtgcagagg ctcacagctt gaacgtgaat     2640

cggttctccc ctgctaacta cgaccaggcg catttacacc cccatctgtt ttcggaccag     2700

tcccggggtt cccccagcag ctacagccct tcaacaggag tggggttctc tccaacccaa     2760

gccctgaaag tccctccact tgaccaattc cccaccttcc ctcccagtgc acatcagcag     2820

ccgccacact ataccacgtc ggcactacag caggccctgc tgtctcccac gccgccagac     2880

tatacaagac accagcaggt accccacatc cttcaaggac tgctttctcc ccggcattcg     2940

ctcaccggcc actcggacat ccggctgccc ccaacagagt ttgcacagct cattaaaagg     3000

cagcagcaac aacggcagca gcagcagcaa cagcagcaac agcaagaata ccaggaactg     3060

ttcaggcaca tgaaccaagg ggatgcgggg agtctggctc ccagccttgg gggacagagc     3120

atgacagagc gccaggcttt atcttatcaa aatgctgact cttatcacca tcacaccagc     3180

ccccagcatc tgctacaaat cagggcacaa gaatgtgtct cacaggcttc ctcacccacc     3240

ccgccccacg ggtatgctca ccagccggca ctgatgcatt cagagagcat ggaggaggac     3300

tgctcgtgtg agggggccaa ggatggcttc caagacagta agagttcaag tacattgacc     3360

aaaggttgcc atgacagccc tctgctcttg agtaccggtg gacctgggga ccctgaatct     3420

ttgctaggaa ctgtgagtca tgcccaagaa ttggggatac atccctatgg tcatcagcca     3480

actgctgcat tcagtaaaaa taaggtgccc agcagagagc ctgtcatagg gaactgcatg     3540

gatagaagtt ctccaggaca agcagtggag ctgccggatc acaatgggct cgggtaccca     3600

gcacgcccct ccgtccatga gcaccacagg ccccgggccc tccagagaca ccacacgatc     3660

cagaacagcg acgatgctta tgtacagctg gataacttgc caggaatgag tctcgtggct     3720

gggaaagcac ttagctctgc ccggatgtcg gatgcagttc tcagtcagtc ttcgctcatg     3780

ggcagccagc agtttcagga tggggaaaat gaggaatgtg gggcaagcct gggaggtcat     3840

gagcacccag acctgagtga tggcagccag catttaaact cctcttgcta tccatctacg     3900

tgtattacag acattctgct cagctacaag caccccgaag tctccttcag catggagcag     3960

gcaggcgtgt aacaagaaac agagagtttt gtgtacagct tgggaatgaa aaggttgatt     4020

gtaaacccac agtatctagc agcgttgtgc caaattgccc ttgtgtttct ctccacccaa     4080

aatatcacag ctgctttcct cacatttggt tcatccgtgt gctgttcttt tgggttctga     4140

gagggttttg ccatgtttgc ttgtatgacc aagtcaccaa ggaaataaac aggaaggaaa     4200

tccatgttct ccatcttttg tgaaagtata tttgagttgg tggttttttg ttttgtttgg     4260

gggtttgtgt tttgttttgt ttttggtatg ttttcttcca gaggtgatat actttctttt     4320

ttttcttcct ttcttttttt tctttcgttc cttttttgaa acaggagagc aaagcagtta     4380

gagttcagag gccagcggcc tcagggccac tccctcccta gccttcatca gcagagcacc     4440

ctccatcccc ctgcattgct cttctgtgaa agcaaatact aaaggatgcc atcctctgga     4500

atcctaatgg caggcaaagg gagagaggaa gggtgacggc ttctggcact tagaaaacaa     4560

aaagaacaaa aaaagagaaa cccccaagcc tggaacgcag agaggtcttt actgctggga     4620

tccacggaaa acatgtctgt cctagccaag atcatatgaa gagtttggca cggaggctga     4680

gaatgacctg gcatagatgg tttgccagtt aggatgtctc aatttgagcc tttgcttttg     4740

gtggataact cagctcccct cttgtaacct ggaaagttgg ttgcctttat catcctgctg     4800

gttttatcca tggactgaac acccaacagc agtgcactat gctttctatg gcatctttca     4860

ttctcatttt atattgtgct ataaaaagga ttgtttctcc atatatatat tatatatgtg     4920

tgtatatata taatataata tatgtgtata tatatattat atatataata tataatataa     4980

tatattatat atatattata tatataatat atatataaaa tatatatata tatgctctcc     5040

tctttcagcc tctttgtcac agggaagaag tgtaggaggt tgccttgggc cctgcctctc     5100

tcctaacctc ctcttcccca ctgggtaccc tcagccccta tattttaatt cttgatcatg     5160

tagaaattgt ttttggtaaa tgttgatatt attgttatta tcattattaa taaataaaga     5220

gaaaaggaat ttttgtttaa atgagaaatg tttaaccaga ttctgttcta tttgaattgt     5280

gacttgcacc ttttgttcaa agtatttcct ttaggcattg taattgtgaa cagctcttac     5340

ttgtgccagt gacagatgca gtggtctcct ttccccagtt gaagcagtgc atacgcagta     5400

gctattattt gtgttatctt tatttctctt cattgttaga aaccaaagtc ttctctgctg     5460

gctggggctg agagagggtc tgggttatct ccttctgatc ttcaaaacaa gagagagacc     5520

ttgaatacac tgactcttcc accctttttt tttctgggaa aggagagcaa gaggtcccga     5580

gtcccctcct agtctttcat cctgaatttg cacagaggaa agcgggtgcc cggcatggcc     5640

atcctgatgt tgctggcggg atccccatgc accttgtcct tctccactga tactggcagc     5700

tcggctcctg gacccaagat cccttgagtg gaattctgca gtgcaagagc ccttcgtggg     5760

agctgtccca tgtttccatg gtccccagtc tcccctccac ttggtggggt caccaactac     5820

tcaccagaag ggggcttacc aagaaagccc taaaaagctg ttgacttatc tgcgcttgtt     5880

ccaactctta tgcccccaac ctgccctacc accaccacgc gctcagcctg atgtgtttac     5940

atggtactgt atgtatggga gagcagactg caccctccag caacaacaga tgaaagccag     6000

tgagcctact aaccgtgcca tcttgcaaac tacactttaa aaaaaactca ttgctttgta     6060

ttgtagtaac caatatgtgc agtatacgtt gaatgtatat gaacatactt tcctatttct     6120

gttctttgaa aatgtcagaa atattttttt ctttctcatt ttatgttgaa ctaaaaagga     6180

ttaaaaaaaa aatctccaga ctcaagttgc taa                                  6213


<210> 1958
<211> 2030
<212> DNA
<213> Homo sapiens

<400> 1958
cccgtccatt gtgcgccgct gccccgtgtc tccctccagc cgcgaccatg cccaggaaga       60

aggcggcggc ggcggcctgg gaggagccga gctcgggcaa cggcactgcc cgcgccgggc      120

ccaggaaacg cggcggcccg gcgggcagga agcgcgagcg gcccgagcgc tgcagtagca      180

gcagcggcgg cggcagcagc ggcgacgagg acggcctgga gctcgacggg gcccccggcg      240

ggggcaagcg cgcggcgcgg ccggcgacag caggcaaggc gggcggcgcg gccgtggtca      300

tcaccgaacc cgagcacacc aaggagcgcg tcaaacttga agggtcaaag tgcaaagggc      360

agcttttgat ttttggggca accaactggg acttgattgg tcgaaaagaa gtgcctaaac      420

agcaagctgc ttaccgcaat ctcggtcaga atttgtgggg gccccacaga tatgggtgcc      480

tggcgggggt ccgggtgcgg acagtggtct cgggctcgtg tgctgcacac agcctcctca      540

tcaccacgga agggaagctg tggagctggg gtcgaaatga gaaggggcag ctgggacatg      600

gtgacaccaa gagagtagaa gcccctagac tcatcgaggg tcttagccac gaagtgattg      660

tgtctgcagc atgtgggcgg aaccacacct tggccttgac ggaaacgggc tccgtgtttg      720

cgtttgggga aaacaagatg gggcagctgg gccttggcaa ccagacagac gctgttccca      780

gccccgcgca gataatgtac aacggccagc caattaccaa aatggcctgt ggggctgaat      840

tcagtatgat aatggactgc aaaggaaacc tctattcctt tgggtgccct gaatatggtc      900

agctgggaca caactcagat gggaagttca tcgcccgggc acagcggata gagtacgact      960

gtgaactagt tccccggcga gtggccatct tcattgagaa gacgaaagat ggacagattc     1020

tgcctgtacc aaacgtggtt gtacgagacg tggcctgtgg cgctaaccac acgctggtcc     1080

tggactccca gaagcgagtc ttctcctggg gctttggtgg ctatggccgg ctgggccacg     1140

cagagcagaa ggatgagatg gtcccccgcc tggtgaagct gtttgacttc cctgggcgtg     1200

gggcttccca gatctatgct ggttacacct gctcctttgc tgtcagtgaa gtgggtggtc     1260

tgtttttctg gggggccacc aacacctccc gtgaatctac catgtaccca aaagcagtgc     1320

aggacctctg cggctggaga atccggagcc tggcttgtgg gaagagcagc atcattgtgg     1380

ccgccgatga gagcaccatc agctggggtc cgtcaccgac ctttggggaa ctgggctacg     1440

gggaccacaa gcccaagtct tccactgcag cccaggaggt aaagactctg gatggcattt     1500

tctcagagca ggtcgccatg ggctactcac actccttggt gatagcaaga gatgaaagtg     1560

agactgagaa agagaagatc aagaaactgc cagaatacaa cccccgaacc ctctgatgct     1620

cccggagact cctccgactc cacacctctc gcggcagctg tcatttccat gtgcactggg     1680

acgggaagtc aaacgaggaa tttaaaaaag caaaagttga ccgaaggtgc atttttgttt     1740

agactccctg aggttccgtt ttacacatga tccaacgtta actacctttt tttctgtatg     1800

ctttccaaag tccttttttt tcccttaatg ttgaattaaa atacttgctc atagttgatt     1860

taccattcct acaaaagagg cagaaacttt gagcaatcta ggtttttttt ttttttaagt     1920

tttttctttc ttcctctcct gaatacactc cccaaaacac ccctttccag ttacaattag     1980

catcgtgatc caagcagatg ccacatggaa gaggaatcgc catttactca                2030


<210> 1959
<211> 4087
<212> DNA
<213> Homo sapiens

<400> 1959
cgcacatgtg tttctgtttt gtgttgtagc atttgttctg gaagctcgta tttacatttt       60

aagtgtatct ggtgagtggg ctggagccct cgtctgggcc ggaaaaaaaa aagccctccg      120

atccgtcttt tagttgcttc tcttcctttt ttctctccgg tttctcatca ctccaaccag      180

ccgcgaccat gcccaggaag aaggcggcgg cggcggcctg ggaggagccg agctcgggca      240

acggcactgc ccgcgccggg cccaggaaac gcggcggccc ggcgggcagg aagcgcgagc      300

ggcccgagcg ctgcagtagc agcagcggcg gcggcagcag cggcgacgag gacggcctgg      360

agctcgacgg ggcccccggc gggggcaagc gcgcggcgcg gccggcgaca gcaggcaagg      420

cgggcggcgc ggccgtggtc atcaccgaac ccgagcacac caaggagcgc gtcaaacttg      480

aagggtcaaa gtgcaaaggg cagcttttga tttttggggc aaccaactgg gacttgattg      540

gtcgaaaaga agtgcctaaa cagcaagctg cttaccgcaa tctcggtcag aatttgtggg      600

ggccccacag atatgggtgc ctggcggggg tccgggtgcg gacagtggtc tcgggctcgt      660

gtgctgcaca cagcctcctc atcaccacgg aagggaagct gtggagctgg ggtcgaaatg      720

agaaggggca gctgggacat ggtgacacca agagagtaga agcccctaga ctcatcgagg      780

gtcttagcca cgaagtgatt gtgtctgcag catgtgggcg gaaccacacc ttggccttga      840

cggaaacggg ctccgtgttt gcgtttgggg aaaacaagat ggggcagctg ggccttggca      900

accagacaga cgctgttccc agccccgcgc agataatgta caacggccag ccaattacca      960

aaatggcctg tggggctgaa ttcagtatga taatggactg caaaggaaac ctctattcct     1020

ttgggtgccc tgaatatggt cagctgggac acaactcaga tgggaagttc atcgcccggg     1080

cacagcggat agagtacgac tgtgaactag ttccccggcg agtggccatc ttcattgaga     1140

agacgaaaga tggacagatt ctgcctgtac caaacgtggt tgtacgagac gtggcctgtg     1200

gcgctaacca cacgctggtc ctggactccc agaagcgagt cttctcctgg ggctttggtg     1260

gctatggccg gctgggccac gcagagcaga aggatgagat ggtcccccgc ctggtgaagc     1320

tgtttgactt ccctgggcgt ggggcttccc agatctatgc tggttacacc tgctcctttg     1380

ctgtcagtga agtgggtggt ctgtttttct ggggggccac caacacctcc cgtgaatcta     1440

ccatgtaccc aaaagcagtg caggacctct gcggctggag aatccggagc ctggcttgtg     1500

ggaagagcag catcattgtg gccgccgatg agagcaccat cagctggggt ccgtcaccga     1560

cctttgggga actgggctac ggggaccaca agcccaagtc ttccactgca gcccaggagg     1620

taaagactct ggatggcatt ttctcagagc aggtcgccat gggctactca cactccttgg     1680

tgatagcaag agatgaaagt gagactgaga aagagaagat caagaaactg ccagaataca     1740

acccccgaac cctctgatgc tcccggagac tcctccgact ccacacctct cgcggcagct     1800

gtcatttcca tgtgcactgg gacgggaagt caaacgagga atttaaaaaa gcaaaagttg     1860

accgaaggtg catttttgtt tagactccct gaggttccgt tttacacatg atccaacgtt     1920

aactaccttt ttttctgtat gctttccaaa gtcctttttt ttcccttaat gttgaattaa     1980

aatacttgct catagttgat ttaccattcc tacaaaagag gcagaaactt tgagcaatct     2040

aggttttttt tttttttaag ttttttcttt cttcctctcc tgaatacact ccccaaaaca     2100

cccctttcca gttacaatta gcatcgtgat ccaagcagat gccacatgga agaggaatcg     2160

ccatttactc agaaaaaatg tcccttacag gaaccggcag cagctaggca gtcaccggcc     2220

cgcctccatc caaaatcacg ctcgcgtgct tcggaagcat ccgggtcact ccttctccgc     2280

tttttcttgc agatgggcct aggccggtgt cggttctgtt tctccccttg gctgcctgta     2340

cgcccacagc cttctggctg cgacattata gaatcggccg tgtcccccct ggtgggggat     2400

tggggatctg tgtttagcca tttatatcta ctttagctgt taaagaggtc caaatgaaaa     2460

tcaggtgatt gtggaaccat ggggacttgg gggtggggca gaggtgggaa catttgtatc     2520

agttgagtca gcttggtggc tccctgtgga gccagggctg agccttgtca cgcgcactcg     2580

ccaattaaga gatggaccag ccagcagtca agtgcattct ccagtccttg caagaaggat     2640

cagccctttc tgtgccagcc tcgatcgcct tgtgctttgg tctctttttc tcccccccgc     2700

ctggatcctg cctcgcgcgg gccgtcctgt tgctgagact cggggtaccg ttctgctgac     2760

ccagctccct ttagtcacgt ttgcttggct ctggtaccaa atagttggga ttaccgaaga     2820

gtccccttcc ttgcgtgtca gcacggatgc tgtgactgcc acctgcgtcc tcgtcaagtg     2880

cccgagctcg ccgccgtgtg tgctgcgctg agtgagttat gaggtgcctt tcccggaacc     2940

ctcctctcgc ctggacccaa gagaggcgac agctgtggct ggggctcttg gtttccagag     3000

ggtctggact ggtttgggtg ctttaaaata gatatttagt tcagtggtgc ttatggggga     3060

gatgggacta gaacttaagt gtgagacttg ggtggatggg aaagttaaat attggtctct     3120

tcaagttttt tttttctttt gctttgttac cacttgtcac tgtctccatg ttaaaatgcc     3180

aaaaatgatg tagttgttgt tgcttttttc cctattttcc accccagtcg ctccttaccg     3240

tgactcctgc ccttggaggg catgtagcag tgtctgtcct gccagtccca aggccctgtg     3300

ggaggagact ggcctgcatc tctctaagac ttagtctgac gccacgcgca tctcttgttc     3360

tgtgttcaat cagtagtcca ggggagaagc ttctgctact tcagagcttt gctaaactaa     3420

cctaatttgt ccaaatcacc ccaaaaccac catctctgac gtaagcttcc atgcgacagc     3480

ctgatccgtt tccctggaca ggtctctttc ctggaatgca gcccaggcac ctgtgctcct     3540

ggcacccttg aggtctctcc tttgagccgt ggtcaccgag agggttgagg acgcagcacc     3600

cgaggtccca gcctttgcag gagcctccct gggcttagct ggacttagat cttcggtggc     3660

ctcatgtaaa cgtggcagcc agcctcttct agaaccctag cccagggact ggagcaggaa     3720

agggaccttc aaagtgaaga ctgccttgtc ccgcagctcc ttctggctta gattgaaaaa     3780

tgggcttcct aatgggttaa atcctttaaa acaaggagtt gtgggggaag ggtgtcgtgc     3840

actcctagag aaaggtacac agttgcccgg ttgggaatgt gcttggcgct gaccctgcgg     3900

gcatctgact ggtcttccag ctcaggaaaa agaatttgaa agaggcttag cgtgaagggg     3960

aatcaaagag gaggttgtga tttggtcgaa ggtgcctggt ttagtgctgt aattgtctta     4020

ttattttttt tatatatata tttcttggag taaacatttt aaataaacaa caacattgtc     4080

tactgtc                                                               4087


<210> 1960
<211> 855
<212> DNA
<213> Homo sapiens

<400> 1960
aaaaggggcg ggcgagcacg gcccgcgggc ggcgttcgct ggagctggtg gaccgggcgg       60

ctgaccgagg ggcggacgcg cggcggggca gaccgctggg gactgcgggc ggcgctgtgt      120

ccgtcgccat gacagatcag acctattgtg accgcctggt gcaggacacg cctttcctga      180

caggccatgg gcgcttgagt gagcagcagg tggacaggat catcctccag ctgaaccgtt      240

actacccaca gatccttacc aacaaggagg cggaaaagtt ccggaacccc aaggcatcct      300

tgcgtgtgcg gctctgtgac ctcctgagcc acctgcagcg gagcggtgag cgggactgcc      360

aggagttcta ccgagccctg tatatccatg cccagcccct gcacagccgc ctgcccagcc      420

gccacgctct gcagaactca gattgcacag agctagactc gggcagccag agcggcgagc      480

tgagtaacag gggacccatg agcttcctgg ctggcctggg ccttgctgtg ggactggccc      540

tgctcctgta ctgctatccg ccagacccca agggcctgcc agggacccgg cgcgtcctcg      600

gtttctcgcc tgtcatcatc gacagacatg tcagccgcta cctgctggcc ttcctggcag      660

atgacctagg ggggctctga cagaccctgg acccagggcc tcacctgcca ctcaaccaaa      720

gagtcctcga gccggcccgc caaggggact gctgcttctt tttctaaatg catatttttc      780

attatttata atttgtgtaa aaaacacacc ttcaccttac aaggtgctga ccatattaaa      840

tgttcaggtt ctctc                                                       855


<210> 1961
<211> 882
<212> DNA
<213> Homo sapiens

<400> 1961
accctgagtc cggggctcgg gcctcagggc ccgcgagtct gcgaagccag ccctttcagt       60

aggagccttc gctgccaagg tgcagatgtt ggacctgctg gacatcgaag gcctctaccc      120

tctgtacaac cgggttgagc gatacctgga agagtttccc gaggagagaa aaaccttaca      180

aatagatggg ccttatgatg aagcatttta ccagaagctg cttgaccttt ccactgagga      240

tgacgggaca gtggccttcg cgctaacgaa ggtgcagcag taccgcgtcg ccatgactgc      300

caaggactgc tccatcatga ttgcactgtc tccctgtctg caggatgcca gctctgatca      360

aaggcctgtc gtcccttcat cgaggtccag gtttgccttt tccgtgtctg tgctggacct      420

tgacctcaag ccctacgaga gcattcccca tcagtataaa ctggacggca agatcgtcaa      480

ctattattca aagactgtac gtgccaaaga caacgccgtg atgtcgactc ggttcaagga      540

aagcgaagat tgcacattag ttctccacaa ggtctaactc tttccctgca gtgtctttga      600

aacttgaaca taatgtgaag gctgaatgat agagatattt tctgttgtgt tgggtgacct      660

ttggttgtga atgtttttgc ttttaacccc ttttgaggtg ggattgcctc ttggagacat      720

ggaattgaag agcactagaa acaacttcct ggacaaggaa tgtaggaagt gagtgctgtg      780

tcccaggaag ctgctcacac tcttaaaatg gaagtgtccg ttaagccctg ggaagacgtt      840

ctggatagtt cttctttccc aaccagggct catgtctgat tc                         882


<210> 1962
<211> 1334
<212> DNA
<213> Homo sapiens

<400> 1962
ataccctcca tgggcagtaa tgggatgact atccccaggg agcattgcga aggagagagg       60

cggctgaggg actgcacttt ctggggcccc ccgggagagt cagagggcag ttaagaggga      120

tcacaggccc ggcttggtac tgtcactccc cttcccactc cctgctctca gcattctgtc      180

acctccctac cccgtcgcgg tgcccagcca tggccagacc tcccgtgccc ggttcggtgg      240

ttgtcccaaa ctggcacgag agtgccgagg gcaaggagta cctggcttgc attctgcgca      300

agaaccgccg gcgggtgttt gggctgcttg agcggccagt gctgctgccg cctgtgtcca      360

ttgacactgc cagctacaag atctttgtgt ccgggaagag tggtgtgggc aagacggcgc      420

tggtggccaa gctggctggc ctggaggtgc ctgtggtgca ccacgagacc accggcatcc      480

agaccaccgt ggtattttgg ccagccaagc tgcaggccag cagccgtgtc gtcatgtttc      540

gttttgagtt ctgggactgt ggagagtctg cactcaaaaa gttcgatcat atgctgctgg      600

cttgcatgga gaacacagat gccttcctct tcctcttctc cttcactgac cgtgcctcct      660

ttgaagacct ccctggacag ctggcccgca tagcaggtga ggcccctggt gtcgtcagga      720

tggtcatcgg ctccaaattt gaccagtaca tgcacacgga cgtgcccgag cgggacctca      780

cagccttccg gcaggcctgg gagctgcccc tgctacgggt gaagagtgtg ccggggcggc      840

ggctggctga tgggcgcaca ctggacgggc gggctgggct ggccgacgtt gcccacatac      900

tcaatggcct tgctgagcag ctgtggcacc aggaccaggt ggcggctggc ctgcttccca      960

accccccaga gagtgctcct gaatgagtca cgagtggttg cctgtgatcc cacccccaac     1020

cctcaggtct cgacataggg ctggaggctg gggcaggaac atggatccta tctggaggac     1080

tggccagcat ggcctgatca gggaggatgt ggccagagaa ggcccacccg cgagcagcgc     1140

tttccttgca gaattcatgg cagggaggtg gggaccaagg ccctgagctc gaacatctcc     1200

cgtggccttt ccccctttgg cagcaccgat ggaggatgac tgggagaggg ggtgcctctc     1260

aagttacttc aatcaagaac ctgtattggt tgaggtgaca ccatctgttg taacagataa     1320

accccgaaat ccca                                                       1334


<210> 1963
<211> 466
<212> DNA
<213> Homo sapiens

<400> 1963
gggaggagag aaaagccatg gccgacaagg tcctgaagga gaagagaaag cagtttatcc       60

gttcagtggg cgaaggtaca ataaatggct tactgggtga attattggag acaagggtgc      120

tgagccagga agagatagag atagtaaaat gtgaaaatgc tacagttatg gataaggccc      180

gagctttgct tgactctgtt attcggaaag gggctccagc atgccaaatt tgcatcacat      240

acatttgtga agaagacagt cacctggcag ggacgctggg actctcagca ggtccaacat      300

ctggaaatca ccttactaca caagattctc aaatagtact tccttcctag gttcaacttt      360

catttgagca gccagatgat aaagcacaga tgcccagcac tgaaagagtt acttcgacaa      420

gacgtttcta tctcttccca gtacattaaa ataaggaagc tgtatg                     466


<210> 1964
<211> 1257
<212> DNA
<213> Homo sapiens

<400> 1964
ggcctgtaca ttttcaagga attcttgaga ggttcttgga gagattctgg gagccaaaca       60

ctccattggg atcctagctg ttttagagaa caacttgtaa tggagccttc atctcttgag      120

ctgccggctg acacagtgca gcgcattgcg gctgaactca aatgccaccc aacggatgag      180

agggtggctc tccacctaga tgaggaagat aagctgaggc acttcaggga gtgcttttat      240

attcccaaaa tacaggatct gcctccagtt gatttatcat tagtgaataa agatgaaaat      300

gccatctatt tcttgggaaa ttctcttggc cttcaaccaa aaatggttaa aacatatctt      360

gaagaagaac tagataagtg ggccaaaata gcagcctatg gtcatgaagt ggggaagcgt      420

ccttggatta caggagatga gagtattgta ggccttatga aggacattgt aggagccaat      480

gagaaagaaa tagccctaat gaatgctttg actgtaaatt tacatcttct aatgttatca      540

ttttttaagc ctacgccaaa acgatataaa attcttctag aagccaaagc cttcccttct      600

gatcattatg ctattgagtc acaactacaa cttcacggac ttaacattga agaaagtatg      660

cggatgataa agccaagaga gggggaagaa accttaagaa tagaggatat ccttgaagta      720

attgagaagg aaggagactc aattgcagtg atcctgttca gtggggtgca tttttacact      780

ggacagcact ttaatattcc tgccatcaca aaagctggac aagcgaaggg ttgttatgtt      840

ggctttgatc tagcacatgc agttggaaat gttgaactct acttacatga ctggggagtt      900

gattttgcct gctggtgttc ctacaagtat ttaaatgcag gagcaggagg aattgctggt      960

gccttcattc atgaaaagca tgcccatacg attaaacctg cgagatcgga gttctttaat     1020

taggaatgga atgcaacaga tttggacaag tcaaggacaa gagctttaga gagaccaaag     1080

agtttttcac tgttaaagtg tccagtatgt agccgagaac catatggaga acatcaaata     1140

cagtggaaca aatgtaactg ctattgatgt cacactttgt gaagtagtct ttgttgctta     1200

aaaagggtga catctagtgg ctaaacatgt tatttcaaat aaataatatc gaaataa        1257


<210> 1965
<211> 4122
<212> DNA
<213> Homo sapiens

<400> 1965
gcctccttcc ccgccggccg cgctccggag cctccgggcc gcggtggagc gagggcccag       60

gcgaggcgag ggccgggcgg cgggcgccgg gccccgcggc cggcacgacg gagcccccgt      120

acggccggcg gcagcggttg gcggcggccc ccggcccccg gcgcgggaag cggcggcggg      180

gcggcggcgg cggtggcggt ggcggtggcg gcgacggtgg cagcgccatg gagccggggg      240

aggtgaagga ccggatcctg gagaacatct cgctgtcggt gaagaagttg cagagctatt      300

ttgctgcatg tgaggatgag atccctgcca tccggaacca tgacaaggtc ctacagcgtc      360

tgtgtgagca cctggaccac gccctgctgt acggactgca agacctctcc tctggctact      420

gggtgctcgt ggtgcatttt actcggagag aggccatcaa gcagatcgag gtgctgcagc      480

acgtggccac caacctgggg cgcagccgtg cctggctgta cctggccctc aacgagaact      540

ccttggagag ctacctgcgg ttgttccagg agaacctggg cctgctgcat aagtactacg      600

tcaagaatgc cctggtctgc agccacgatc acctgacgct cttcctgacc ttggtgtccg      660

ggctagagtt cattcgtttc gagctggatc tggatgcccc ttacctagac ctggccccct      720

acatgcccga ctactacaaa cctcagtacc tgctggactt tgaagaccgc cttcccagct      780

cggtccacgg ctcagacagt ctgtccctca actctttcaa ctccgtcacc tccaccaacc      840

tggagtggga tgacagtgcg attgccccat ctagtgagga ttatgatttt ggagatgtgt      900

ttccagcagt gccgtctgta cccagcacag actgggaaga tggagacctc acagacacgg      960

tcagtggtcc ccgctccaca gcctccgacc tgaccagcag caaggcctcc accaggagcc     1020

ccacccagcg ccagaacccc ttcaacgagg agccggcaga gactgtgtcc tcctctgaca     1080

ccacccccgt gcacaccacc tctcaggaga aggaggaggc ccaggccctg gacccgccgg     1140

atgcctgcac ggagctcgag gtcatcaggg tcaccaagaa gaagaaaatt ggcaagaaga     1200

aaaagagcag atcagatgag gaggcaagtc cactccaccc cgcctgcagc cagaagaaat     1260

gtgccaagca gggggacggt gacagccgca acggcagccc aagccttggg cgggactcgc     1320

cagacactat gcttgcctcc ccccaggagg agggagaggg gccgagcagc accacggaga     1380

gcagcgagcg ctccgagccg ggcctgctga tccctgagat gaaggacacc tccatggagc     1440

gcttggggca gcccctgagc aaggttatcg accagctcaa cgggcagctg gaccccagca     1500

cctggtgctc ccgtgctgag cccccagacc agtcctttcg gaccggctct cccggggatg     1560

ccccggagag gccgccgctt tgcgacttta gtgaggggct ttcagcccca atggacttct     1620

accgctttac cgtcgagagt ccaagcactg ttacatcagg tggcggccac catgaccctg     1680

cagggcttgg ccaaccgctg catgttccta gtagccctga ggctgctggc caagaagaag     1740

agggaggagg aggagaggga cagacgcctc ggcccctaga ggataccacg agggaggctc     1800

aggagctgga ggcccagctg tccctggtca gggaggggcc tgtgtctgag ccagagcctg     1860

ggacccagga ggttctctgc cagctcaagc gagaccagcc cagcccgtgt ctgagtagcg     1920

ctgaggattc tggggtggat gagggacagg ggagcccttc ggagatggtc cattcctcgg     1980

agttcagagt agacaacaat cacctgctcc tgctcatgat ccacgtgttc cgagaaaacg     2040

aagagcagct gttcaaaatg atccggatga gcaccgggca catggagggc aacctgcagc     2100

tgctgtacgt gctgctcaca gactgctatg tctacctgct ccggaaaggg gccacagaga     2160

agccatacct ggtggaagag gccgtttctt acaatgaact tgactatgtg tcggttggcc     2220

ttgaccagca gacggtgaag ctggtgtgca ccaaccgcag gaagcagttt ctgctggaca     2280

cggctgatgt ggcgctggct gagttctttt tggcttcttt gaagtcagcc atgatcaaag     2340

gctgtcgaga acctccctac cccagcatcc tgacggatgc caccatggag aagctggcac     2400

tggccaaatt tgtggcccaa gaatcgaagt gtgaggcatc tgctgtcacc gtgcgcttct     2460

acggccttgt gcactgggag gaccccacag acgagtccct gggccccacg ccctgccact     2520

gctcaccccc cgagggcacc atcaccaaag aaggcatgct gcactacaag gcgggcacct     2580

cctacctggg caaggaacac tggaagacgt gcttcgtggt gctcagcaac gggatcctct     2640

accagtaccc ggaccgcacc gacgtcatcc ctctgctctc ggtgaacatg gggggggagc     2700

agtgcggtgg ctgccggaga gccaacacca cggatcggcc ccacgccttc caggtcattc     2760

tctccgaccg gccctgcctg gagctaagtg ccgagagcga ggccgagatg gccgagtgga     2820

tgcagcatct ctgccaggct gtgtccaaag gggtcatccc ccagggcgta gctcccagcc     2880

cctgcatacc ctgctgcctg gtcctcacgg atgaccgcct ctttacgtgc catgaggatt     2940

gccagaccag cttcttccgc tctttgggca cagccaagct gggcgacatc agcgccgtct     3000

ccaccgagcc gggcaaggag tactgcgtct tggagttctc ccaggacagc cagcagctcc     3060

tcccgccctg ggtcatctac ctgagctgca cttctgaact ggaccgattg ctgtctgcac     3120

tgaactctgg gtggaaaacc atctatcagg tggacctccc ccacacggcg atccaggaag     3180

cctccaacaa gaagaaattc gaggatgcct tgagcctcat ccacagcgcc tggcagcgga     3240

gcgacagtct ctgccgcggc cgagcctccc gagacccctg gtgctgaggc agagctggtt     3300

ggcgtccctg gtgggcagga aaggaaggca cgccagccgg caggcacact gtcacggctg     3360

ttgtcatgct gtcgggagcc tacagtccac ccctgccctg ggcggcagaa ccaccgagtg     3420

tggcttaaga cagggtccct ccactccagg gatccagatc aggtgcccgg cacccctggg     3480

catcctgccc gacaggtagc gaatggaggt cgctgggggc agagggtccg agccctgtgg     3540

gctctgcgga tgcacgccct cctcccgggc ctccgcctca gtctgcagaa tttctgccga     3600

gtggcaccga gaacaccatc catctaagga cgaacaaaag aaccaggagg gcgggacccc     3660

cctcttcctc tcctgggttg ggggctgggg ccctgagtgc ccagccatcc ttgttcgtgt     3720

ttgaacactc tcctggccac gtggggaagc gggaacacgg ggtgtctgcg catgtttcct     3780

cctcctagct ccatcactgc gcacacagct gcctgcctcg ccagatgcag gggggcgggc     3840

agccctccct ggctgccagg aggctctgca tgcccacagt cctgccctgc ctgtcccctc     3900

aacccggcag tgcctgtagc accgaggagc aaagggggtg gatggggggc ttggagaagg     3960

gcggagccca ccagcctggc atccatgttg acatcttctg actgtcccct gcttggctgg     4020

agccaggccc ttccctagag tttcgtcaag agcctcctgg ggaaggggtc aggtggtttg     4080

ggttttgttt tttaaaataa aatagacatg ttatattgcc aa                        4122


<210> 1966
<211> 1981
<212> DNA
<213> Homo sapiens

<400> 1966
tgcttttgct gtgagcagcc ccaagcagct gggcgctcca tcagaggcaa ctatgacttt       60

tgcaaagcaa acgtgcaacc ccaagcagcg gtctcccggg ccggggctgc gcggccgccg      120

ctgtgctggc ttttaacggt gggagggcac catcctcttg ctctgctctc gttctccaga      180

aggctgtccc ggggccccca ctctccgtcc cgctccgggg acagtggctc gcctgctatg      240

cgcggcagcc cgcgccgggg ccggcaccag cagcgcccgg gcggatgcag cgagcccacg      300

gaggggcatg cttccacgca ccaagtataa ccgcttcagg aatgactcgg tgacatcggt      360

cgatgacctt ctccacagcc tgtcggtgag cggcggcgga ggcaaggttt cggcggcgcg      420

cgcgaccccg gcggcggctc cctacttggt gtccggcgag gcgctgcgca aggcgcccga      480

cgatgggccc ggcagcctgg gccacctgct ccacaaggtg tcccacctga aactctccag      540

ctcgggcctc cgcggcctgt cgtcggccgc ccgggagcgg gcgggcgcgc ggctctcggg      600

cagctgcagc gcgcccagcc tggccgcccc ggacggcagt gcgccctcgg cgccccgcgc      660

cccggccatg agcgccgcca ggaagggccg gcccggcgac gagccgctgc ccaggccccc      720

tcggggggcg ccgcacgcca gcgaccaggt gctggggccc ggagtcacct acgtggtcaa      780

gtacttgggg tgcattgaag ttctgcgctc aatgaggtct cttgacttca gtacaagaac      840

acaaattacc agggaagcca tcagccgcgt ctgtgaagct gtgcctggtg cgaagggagc      900

cttcaagaag agaaagcctc caagcaaaat gctgtccagc atcttgggaa agagcaacct      960

ccagtttgcg ggaatgagca tctctctgac catctccacg gccagtctga acctgcgaac     1020

tccggactcc aaacagatca tagcgaatca ccacatgcgg tccatctcct tcgcctctgg     1080

gggagacccg gacacaactg actatgttgc atatgtggct aaggaccctg ttaatcgcag     1140

agcttgtcac attttggaat gctgtgatgg gctggcccag gatgtcatcg gctccatcgg     1200

acaagccttt gagctccggt ttaagcaata tttacagtgt cctaccaaga ttcccgctct     1260

ccatgatcga atgcagagtc tggatgagcc atggacggaa gaggagggag atggctcaga     1320

ccacccatac tacaacagca tcccaagcaa gatgcctcct ccagggggct ttcttgatac     1380

tagactgaaa cccagacccc atgctcctga cacagcccag tttgcaggaa aagagcagac     1440

ttattaccag ggaagacact taggagacac ttttggcgaa gactggcagc aaacaccttt     1500

aaggcaaggg tcctcggaca tctacagcac gccagaaggg aaactgcacg tggcccccac     1560

gggagaagca cccacctacg tcaacactca gcagatccca ccacaggcct ggccggctgc     1620

ggtcagcagt gctgagagca gcccaaggaa agacctcttt gacatgaaac cttttgaaga     1680

tgctctcaag aaccagccct tggggcccgt gttaagcaag gcagcctccg tggagtgcat     1740

cagccctgtg tcacctagag ccccagatgc caagatgctg gaggaactgc aagccgagac     1800

ttggtaccaa ggagagatga gcaggaagga ggcagagggg ctgctggaga aagacggaga     1860

cttcctggtc aggaagagca ccaccaaccc gggctccttt gtcctcacgg gcatgcacaa     1920

tggccaggcc aagcacctgc tgctcgtgga cccagaaggc acgagaagta actcctactg     1980

a                                                                     1981


<210> 1967
<211> 569
<212> DNA
<213> Homo sapiens

<400> 1967
cccacgggag aagcacccac ctacgtcaac actcagcaga tcccaccaca ggcctggccg       60

gctgcggtca gcagtgctga gagcagccca aggaaagacc tctttgacat gaaacctttt      120

gaagatgctc tcaagaacca gcccttgggg cccgtgttaa gcaaggcagc ctccgtggag      180

tgcatcagcc ctgtgtcacc tagagcccca gatgccaaga tgctggagga actgcaagcc      240

gagacttggt accaaggaga gatgagcagg aaggaggcag aggggctgct ggagaaagac      300

ggagacttcc tggtcaggaa gagcaccacc aacccgggct cctttgtcct cacgggcatg      360

cacaatggcc aggccaagca cctgctgctc gtggacccag aaggcacgag aagtaactcc      420

tactgatgtt ggccatccct ggcactacag ctgtatctga ataatcccgt aggtttggct      480

gaatttttca tcttcccgtc aagaaagaca ttcatcttta cctggggcat agtccaagaa      540

ttgctaagtt taataaatgc agttaaatc                                        569


<210> 1968
<211> 2394
<212> DNA
<213> Homo sapiens

<400> 1968
tgcttttgct gtgagcagcc ccaagcagct gggcgctcca tcagaggcaa ctatgacttt       60

tgcaaagcaa acgtgcaacc ccaagcagcg gtctcccggg ccggggctgc gcggccgccg      120

ctgtgctggc ttttaacggt gggagggcac catcctcttg ctctgctctc gttctccaga      180

aggctgtccc ggggccccca ctctccgtcc cgctccgggg acagtggctc gcctgctatg      240

cgcggcagcc cgcgccgggg ccggcaccag cagcgcccgg gcggatgcag cgagcccacg      300

gaggggcatg cttccacgca ccaagtataa ccgcttcagg aatgactcgg tgacatcggt      360

cgatgacctt ctccacagcc tgtcggtgag cggcggcgga ggcaaggttt cggcggcgcg      420

cgcgaccccg gcggcggctc cctacttggt gtccggcgag gcgctgcgca aggcgcccga      480

cgatgggccc ggcagcctgg gccacctgct ccacaaggtg tcccacctga aactctccag      540

ctcgggcctc cgcggcctgt cgtcggccgc ccgggagcgg gcgggcgcgc ggctctcggg      600

cagctgcagc gcgcccagcc tggccgcccc ggacggcagt gcgccctcgg cgccccgcgc      660

cccggccatg agcgccgcca ggaagggccg gcccggcgac gagccgctgc ccaggccccc      720

tcggggggcg ccgcacgcca gcgaccaggt gctggggccc ggagtcacct acgtggtcaa      780

gtacttgggg tgcattgaag ttctgcgctc aatgaggtct cttgacttca gtacaagaac      840

acaaattacc agggaagcca tcagccgcgt ctgtgaagct gtgcctggtg cgaagggagc      900

cttcaagaag agaaagcctc caagcaaaat gctgtccagc atcttgggaa agagcaacct      960

ccagtttgcg ggaatgagca tctctctgac catctccacg gccagtctga acctgcgaac     1020

tccggactcc aaacagatca tagcgaatca ccacatgcgg tccatctcct tcgcctctgg     1080

gggagacccg gacacaactg actatgttgc atatgtggct aaggaccctg ttaatcgcag     1140

agcttgtcac attttggaat gctgtgatgg gctggcccag gatgtcatcg gctccatcgg     1200

acaagccttt gagctccggt ttaagcaata tttacagtgt cctaccaaga ttcccgctct     1260

ccatgatcga atgcagagtc tggatgagcc atggacggaa gaggagggag atggctcaga     1320

ccacccatac tacaacagca tcccaagcaa gatgcctcct ccagggggct ttcttgatac     1380

tagactgaaa cccagacccc atgctcctga cacagcccag tttgcaggaa aagagcagac     1440

ttattaccag ggaagacact taggagacac ttttggcgaa gactggcagc aaacaccttt     1500

aaggcaaggg tcctcggaca tctacagcac gccagaaggg aaactgcacg tggcccccac     1560

gggagaagca cccacctacg tcaacactca gcagatccca ccacaggcct ggccggctgc     1620

ggtcagcagt gctgagagca gcccaaggaa agacctcttt gacatgaaac cttttgaaga     1680

tgctctcaag aaccagccct tggggcccgt gttaagcaag gcagcctccg tggagtgcat     1740

cagccctgtg tcacctagag ccccagatgc caagatgctg gaggaactgc aagccgagac     1800

ttggtaccaa ggagagatga gcaggaagga ggcagagggg ctgctggaga aagacggaga     1860

cttcctggtc aggaagagca ccaccaaccc gggctccttt gtcctcacgg gcatgcacaa     1920

tggccaggcc aagcacctgc tgctcgtgga cccagaaggc acgatccgga caaaggacag     1980

agtctttgac agtatcagcc acctcatcaa ccaccaccta gaaagcagcc tgcccattgt     2040

ctctgcaggg agtgagctgt gtctccagca gccagtggag aggaagcagt gacctggcca     2100

gcactgctcc cagcactgcg caccaggtca ggaggacctg gagtggacta gaatcggggc     2160

tgctggaact gggacagctg cctgtggctc agagccttct tcaaaagctt caaaaggaag     2220

gcttccttta aggtcaagtt tcataaactt ggttctgaat ttctcatatg catattaaag     2280

gtgtacatac ctatacatcc tgtacaaatt atccctctat atttatattt tttaagacta     2340

agaaagatgt aagactaatg ttctgtgctg tatgttttta atgaaaaaaa aaaa           2394


<210> 1969
<211> 2402
<212> DNA
<213> Homo sapiens

<400> 1969
gaggtggggg cgggggcctt accccaccct ggcaccggca ggcgcgggcg gatgggggga       60

tgtcgcctag agccccccgg ccggcccaca aactcccgtc ccccttccgg ctctgcctgg      120

acgtccctgc gggccccggg ggaaagcacc caacttctcc cgcctcggct tctagcagaa      180

acgtgacggg gctggacttt gatcgccgag ggctctctgc tcttcagagt ctgcttggaa      240

cgggataaga gggatggtgc catccaggga agctctgctg ggaccaggca caactgccat      300

taggtgcccc aagaaattac agaaccaaaa ttacaagggc catggattgt caaagggaaa      360

agagcgagag cagagagcat cgatccggtt caagaccacc ctcatgaaca cactcatgga      420

cgtccttcgc cacaggccag gatgggtgga agtgaaggac gaaggggagt gggatttcta      480

ctggtgtgac gtcagctggc tccgggagaa cttcgaccac acctacatgg atgaacatgt      540

gcggatcagt cacttccgga accactatga gctgacccgg aagaactaca tggtgaagaa      600

cctgaagcgg ttccggaagc agctggagcg tgaggcagga aagctggagg cagccaagtg      660

tgacttcttc cccaaaacct ttgagatgcc ttgcgagtac cacctgtttg tagaggagtt      720

tcgcaaaaac ccaggaatca cctggatcat gaagcctgac acaagaagct ctgacgacca      780

gaaagatgat attcccgtgg agaactatgt ggctcagcgt tacattgaaa atccttacct      840

gataggaggc cgcaagtttg acctgcgtgt ctatgtgctg gtgatgtcgt acatcccgct      900

gcgggcctgg ctctaccggg atggctttgc ccgattctcc aacacccgct tcacactgaa      960

cagcattgat gaccagtatg ttcacctcac caacgtggct gtgcaaaaaa catctcccga     1020

ctaccaccca aagaaggtgg ctcctggagg tcaatgcgtc cccatcactg acagccagca     1080

gccaggaaga ctatgagctc aagacctgcc tcctggaaga caccctgcat gttgtggaca     1140

tggaagcgag gctcacggga agggagaagc gagtcggggg ctttgacctc atgtggaatg     1200

atggccctgt tagcagagag gagggggctc ctgacctgtc gggaatggga aactttgtga     1260

ccaacacaca tctcggctgc gtcaacgatc ggaagaaaca actgaggcag ctcttctgct     1320

cccttcaagt tcagaagaaa gcttccagtt gatccccagc tgccaggagg aaatcagcct     1380

tagcaggcct tgtgtttgag attgggagct gagccagaaa ccggaaaacc ctgggctcat     1440

gggcaggaca gcttcgggag ttgagtgtca agcccgaagg gaagactttt ggaaggaaaa     1500

tactggcaaa tccaagaagt gaaccagccg actttaggaa agccagaagc caggctactc     1560

tagaccttct gccttcagag catgaggact tctcccactc atccctgtac ctgaggcaca     1620

ccaacccaga caggtccagg catggactcc aggttcccta tttccagaag gaatgcgatt     1680

agcttttttt ggcccagcac ccaccctgcc agggaggaag gggcaatttt ccagtgatga     1740

aattgtgaat caggcagtca cactggacaa catctagcaa ggtgaattct gcaactccct     1800

actttattta cattttaaaa taagcaatat attcatacgg tttaaaatcc aaagtttaca     1860

aaagggtata gggtgacatc tccttccctc ccacctgtgc gccccaaccc tgcaggtgct     1920

gttctgaggg aatcacactg tgcttgcaca aaaattatta gcttataaga caccagcctt     1980

ccccttgctt tcctcacttg atgtatcttg gagcttgttc cttattcttg attatagttg     2040

tatggtattg cactatctgg agctaacacc tgtgacccac actcatgttt taaaagtttc     2100

tgcattagtc aaaaatattt aaaaggagat tcaacttcac aacccatatg tctagcttct     2160

cttgaaaaca cgtaagaact ggccatgaca gcctgtgttt ctatgtaact atgagccaga     2220

gccaaggagc ggggggacca ggagaggtgt gcccctgcca tgctgccatt tgttatcacc     2280

cgcctgtcaa atcacaggtt tatttcaagg caagaaccat gttcataggt tgtattctaa     2340

atggagtggc gtgcccttac tgaaggacta gatgaggcaa ataaagacta gttgctgcta     2400

tt                                                                    2402


<210> 1970
<211> 1514
<212> DNA
<213> Homo sapiens

<400> 1970
aagcacgcga ggcgcgcggt ggcggtttgg atctggcccc tggggaatcg cgttatgtcg       60

cgaccgaaga gagcagagag catcgatccg gttcaagacc accctcatga acacactcat      120

ggacgtcctt cgccacaggc caggatgggt ggaagtgaag gacgaagggg agtgggattt      180

ctactggtgt gacgtcagct ggctccggga gaacttcgac cacacctaca tggatgaaca      240

tgtgcggatc agtcacttcc ggaaccacta tgagctgacc cggaagaact acatggtgaa      300

gaacctgaag cggttccgga agcagctgga gcgtgaggca ggaaagctgg aggcagccaa      360

gtgtgacttc ttccccaaaa cctttgagat gccttgcgag taccacctgt ttgtagagga      420

gtttcgcaaa aacccaggaa tcacctggat catgaagcct gacacaagaa gctctgacga      480

ccagaaagat gatattcccg tggagaacta tgtggctcag cgttacattg aaaatcctta      540

cctgatagga ggccgcaagt ttgacctgcg tgtctatgtg ctggtgatgt cgtacatccc      600

gctgcgggcc tggctctacc gggatggctt tgcccgattc tccaacaccc gcttcacact      660

gaacagcatt gatgaccagt atgttcacct caccaacgtg gctgtgcaaa aaacatctcc      720

cgactaccac ccaaagaagg gctgcaagtg gacgctgcag cgcttccggc agtacctggc      780

gtccaaacac gggcccgagg cagtggagac actcttcagg gacatcgaca acatctttgt      840

caaaagcctg cagagtgtgc agaaggtgat catcagtgac aagcactgct tcgagctgta      900

cggctatgac atcctcatcg accaggacct caagccgtgg ctcctggagg tcaatgcgtc      960

cccatcactg acagccagca gccaggaaga ctatgagctc aagacctgcc tcctggaaga     1020

caccctgcat gttgtggaca tggaagcgag gctgcgtcaa cgatcggaag aaacaactga     1080

ggcagctctt ctgctccctt caagttcaga agaaagcttc cagttgatcc ccagctgcca     1140

ggaggaaatc agccttagca ggccttgtgt ttgagattgg gagctgagcc agaaaccgga     1200

aaaccctggg ctcatgggca ggacagcttc gggagttgag tgtcaagccc gaagggaaga     1260

cttttggaag gaaaatactg gcaaatccaa gaagtgaacc agccgacttt aggaaagcca     1320

gaagccaggc tactctagac cttctgcctt cagagcatga ggacttctcc cactcatccc     1380

tgtacctgag gcacaccaac ccagacaggt ccaggcatgg actccaggtt ccctatttcc     1440

agaaggaatg cgattagctt tttttggccc agcacccacc ctgccaggga ggaaggggca     1500

attttccagt gatg                                                       1514


<210> 1971
<211> 1263
<212> DNA
<213> Homo sapiens

<400> 1971
aagcacgcga ggcgcgcggt ggcggtttgg atctggcccc tggggaatcg cgttatgtcg       60

cgaccgaaga accaaaatta caagggccat ggattgtcaa agggaaaaga gcgagagcag      120

agagcatcga tccggttcaa gaccaccctc atgaacacac tcatggacgt ccttcgccac      180

aggccaggat gggtggaagt gaaggacgaa ggggagtggg atttctactg gtgtgacgtc      240

agctggctcc gggagaactt cgaccacacc tacatggatg aacatgtgcg gatcagtcac      300

ttccggaacc actatgagct gacccggaag aactacatgg tgaagaacct gaagcggttc      360

cggaagcagc tggagcgtga ggcaggaaag ctggaggcag ccaagtgtga cttcttcccc      420

aaaacctttg agatgccttg cgagtaccac ctgtttgtag aggagtttcg caaaaaccca      480

ggaatcacct ggatcatgaa gcctgtagcc cggtctcaag ggaaaggcat cttcctcttc      540

cgtaggctga aggacatcgt ggactggagg aaggacacaa gaagctctga cgaccagaaa      600

gatgatattc ccgtggagaa ctatgtggct cagcgttaca ttgaaaatcc ttacctgata      660

ggaggccgca agtttgacct gcgtgtctat gtgctggtga tgtcgatgtt cacctcacca      720

acgtggctgt gcaaaaaaca tctcccgact accacccaaa gaagggctgc aagtggacgc      780

tgcagcgctt ccggcagtac ctggcgtcca aacacgggcc cgaggcagtg gagacactct      840

tcagggacat cgacaacatc tttgtcaaaa gcctgcagag tgtgcagaag gtgatcatca      900

gtgacaagca ctgcttcgag ctgtacggct atgacatcct catcgaccag gacctcaagc      960

cgtggctcct ggaggtcaat gcgtccccat cactgacagc cagcagccag gaagactatg     1020

agctcaagac ctgcctcctg gaagacaccc tgcatgttgt ggacatggaa gcgaggctca     1080

cgggaaggga gaagcgagtc gggggctttg acctcatgtg gaatgatggc cctgttagca     1140

gagaggaggg ggctcctgac ctgtcgggaa tgggaaactt tgtgaccaac acacatctcg     1200

gctgcgtcaa cgatcggaag aaacaactga ggcagctctt ctgctccctt caagttcaga     1260

aga                                                                   1263


<210> 1972
<211> 1290
<212> DNA
<213> Homo sapiens

<400> 1972
ataagcacgc gaggcgcgcg gtggcggttt ggatctggcc cctggggaat cgcgttatgt       60

cgcgaccgaa gaaccaaaat tacaagggcc atggattgtc aaagggaaaa gagcgagagc      120

agagagcatc gatccggttc aagaccaccc tcatgaacac actcatggac gtccttcgcc      180

acaggccagg atgggtggaa gtgaaggacg aaggggagtg ggatttctac tggtgtgacg      240

tcagctggct ccgggagaac ctggagcgtg aggcaggaaa gctggaggca gccaagtgtg      300

acttcttccc caaaaccttt gagatgcctt gcgagtacca cctgtttgta gaggagtttc      360

gcaaaaaccc aggaatcacc tggatcatga agcctgtagc ccggtctcaa gggaaaggca      420

tcttcctctt ccgtaggctg aaggacatcg tggactggag gaaggacaca agaagctctg      480

acgaccagaa agatgatatt cccgtggaga actatgtggc tcagcgttac attgaaaatc      540

cttacctgat aggaggccgc aagtttgacc tgcgtgtcta tgtgctggtg atgtcgtaca      600

tcccgctgcg ggcctggctc taccgggatg gctttgcccg attctccaac acccgcttca      660

cactgaacag cattgatgac cagtatgttc acctcaccaa cgtggctgtg caaaaaacat      720

ctcccgacta ccacccaaag aagctccatc ccacagtggg gcccttgtgc atacacagcc      780

ctgaaaatgg cagcctgtcg gtcactcctt ggccttggga tgcacacatg ggctgcaagt      840

ggacgctgca gcgcttccgg cagtacctgg cgtccaaaca cgggcccgag gcagtggaga      900

cactcttcag ggacatcgac aacatctttg tcaaaagcct gcagagtgtg cagaaggtga      960

tcatcagtga caagcactgc ttcgagctgt acggctatga catcctcatc gaccaggacc     1020

tcaagccgtg gctcctggag gtcaatgcgt ccccatcact gacagccagc agccaggaag     1080

actatgagct caagacctgc ctcctggaag acaccctgca tgttgtggac atggaagcga     1140

gcttttcccc gattattcca gcagaagttt gagggctgat tctccttgct ggtaactggg     1200

acacattccc attcctaaac cactcactgt gactctgctt gaccaggctc acgggaaggg     1260

agaagcgagt cgggggcttt gacctcatgt                                      1290


<210> 1973
<211> 2623
<212> DNA
<213> Homo sapiens

<400> 1973
gaggtggggg cgggggcctt accccaccct ggcaccggca ggcgcgggcg gatgggggga       60

tgtcgcctag agccccccgg ccggcccaca aactcccgtc ccccttccgg ctctgcctgg      120

acgtccctgc gggccccggg ggaaagcacc caacttctcc cgcctcggct tctagcagaa      180

acgtgacggg gctggacttt gatcgccgag ggctctctgc tcttcagagt ctgcttggaa      240

cgggataaga gggatggtgc catccaggga agctctgctg ggaccaggca caactgccat      300

taggtgcccc aagaaattac agaaccaaaa ttacaagggc catggattgt caaagggaaa      360

agagcgagag cagagagcat cgatccggtt caagaccacc ctcatgaaca cactcatgga      420

cgtccttcgc cacaggccag gatgggtgga agtgaaggac gaaggggagt gggatttcta      480

ctggtgtgac gtcagctggc tccgggagaa cttcgaccac acctacatgg atgaacatgt      540

gcggatcagt cacttccgga accactatga gctgacccgg aagaactaca tggtgaagaa      600

cctgaagcgg ttccggaagc agctggagcg tgaggcagga aagctggagg cagccaagtg      660

tgacttcttc cccaaaacct ttgagatgcc ttgcgagtac cacctgtttg tagaggagtt      720

tcgcaaaaac ccaggaatca cctggatcat gaagcctgta gcccggtctc aagggaaagg      780

catcttcctc ttccgtaggc tgaaggacat cgtggactgg aggaaggaca caagaagctc      840

tgacgaccag aaagatgata ttcccgtgga gaactatgtg gctcagcgtt acattgaaaa      900

tccttacctg ataggaggcc gcaagtttga cctgcgtgtc tatgtgctgg tgatgtcggt      960

gtttgctgaa tgcctgctgt ggtctgggca caggagacag gatgttcacc tcaccaacgt     1020

ggctgtgcaa aaaacatctc ccgactacca cccaaagaag ggctgcaagt ggacgctgca     1080

gcgcttccgg cagtacctgg cgtccaaaca cgggcccgag gcagtggaga cactcttcag     1140

ggacatcgac aacatctttg tcaaaagcct gcagagtgtg cagaaggtga tcatcagtga     1200

caagcactgc ttcgagctgt acggctatga catcctcatc gaccaggacc tcaagccgtg     1260

gctcctggag gtcaatgcgt ccccatcact gacagccagc agccaggaag actatgagct     1320

caagacctgc ctcctggaag acaccctgca tgttgtggac atggaagcga ggctcacggg     1380

aagggagaag cgagtcgggg gctttgacct catgtggaat gatggccctg ttagcagaga     1440

ggagggggct cctgacctgt cgggaatggg aaactttgtg accaacacac atctcggctg     1500

cgtcaacgat cggaagaaac aactgaggca gctcttctgc tcccttcaag ttcagaagaa     1560

agcttccagt tgatccccag ctgccaggag gaaatcagcc ttagcaggcc ttgtgtttga     1620

gattgggagc tgagccagaa accggaaaac cctgggctca tgggcaggac agcttcggga     1680

gttgagtgtc aagcccgaag ggaagacttt tggaaggaaa atactggcaa atccaagaag     1740

tgaaccagcc gactttagga aagccagaag ccaggctact ctagaccttc tgccttcaga     1800

gcatgaggac ttctcccact catccctgta cctgaggcac accaacccag acaggtccag     1860

gcatggactc caggttccct atttccagaa ggaatgcgat tagctttttt tggcccagca     1920

cccaccctgc cagggaggaa ggggcaattt tccagtgatg aaattgtgaa tcaggcagtc     1980

acactggaca acatctagca aggtgaattc tgcaactccc tactttattt acattttaaa     2040

ataagcaata tattcatacg gtttaaaatc caaagtttac aaaagggtat agggtgacat     2100

ctccttccct cccacctgtg cgccccaacc ctgcaggtgc tgttctgagg gaatcacact     2160

gtgcttgcac aaaaattatt agcttataag acaccagcct tccccttgct ttcctcactt     2220

gatgtatctt ggagcttgtt ccttattctt gattatagtt gtatggtatt gcactatctg     2280

gagctaacac ctgtgaccca cactcatgtt ttaaaagttt ctgcattagt caaaaatatt     2340

taaaaggaga ttcaacttca caacccatat gtctagcttc tcttgaaaac acgtaagaac     2400

tggccatgac agcctgtgtt tctatgtaac tatgagccag agccaaggag cggggggacc     2460

aggagaggtg tgcccctgcc atgctgccat ttgttatcac ccgcctgtca aatcacaggt     2520

ttatttcaag gcaagaacca tgttcatagg ttgtattcta aatggagtgg cgtgccctta     2580

ctgaaggact agatgaggca aataaagact agttgctgct att                       2623


<210> 1974
<211> 800
<212> DNA
<213> Homo sapiens

<400> 1974
gggagaggga aggtcaggct tgcctcctgt tcacaaggac aacctctgtc tcccttgtgg       60

cggcttctat gaaggtgggg actccaggct ttctctcgtc tgctttttgg atgccttcaa      120

gagaggccag ttagaggata tcaattgtgg caattcccca gagccctcat cagatggcat      180

tagcccgtca tgtgctgcag tggcacccag tttggaggaa attcggaacc agaagagtgt      240

gacagtgctc ctgcgggaag aagtgtcgcg gctccaggag gaagttcacc ttctccggca      300

gatgaaggag atgttggcga aggacctgga ggagtcgcag ggcggcaagt cctctgaggt      360

cctctcggcc accgagctca gggtccagct ggcccagaag gagcaggagc tagccagagc      420

caaagaagcc ttgcaggcca tgaaagctga tcggaagcgc ttaaagggcg agaagacaga      480

cctggtgagc cagatgcagc agctgtatgc cacactggag agccgcgagg agcagctccg      540

agacttcatc cgcaactatg agcagcaccg caaggagagc gaggatgcgg tcaaagcgct      600

ggccaaggag aaggacctgc tggagcgtga gaagtgggag ctgcggcgcc aagccaagga      660

ggccacagac cacgccacgg cactgcgctc ccagctggac ctcaaggaca accggatgaa      720

ggagctggag gccgagctgg ccatggccaa acagtcctta gctacgctga ccaaggacgt      780

ccccaagcgg cattccctcg                                                  800


<210> 1975
<211> 6030
<212> DNA
<213> Homo sapiens

<400> 1975
gcgcccgccc gccggggtct cggcgatcgc tgctcctcct cctccttctc ctcctctttt       60

ttctcctccg cctcctcccc ccgccgcctc gccaccgccg cggctagggc tggaggcgcc      120

gctgtcattc ctgtgccgga ggaaccggcg ctgccggtgc ctgggggtcg gggcgcgggc      180

gaagccgggc cgcggaggac acaacaggta gagccggggg tgcccggccg cgcgcccccc      240

gcgcatcatg cagctctttg tcacctctct cgcccccagg ccaaaatcct gagcatgatg      300

gaagacaata agcagctcgc gctccgcatc gatggggcgg tccagtcggc cagccaggag      360

gtgaccaacc tgcgagccga actcacggcc accaaccgga gactggcgga actgagcggc      420

ggcggcggcc ccggcccggg cccgggagcc gcggccagcg cctcggcggc gggggactcg      480

gcggcgacga acatggagaa cccccagctt ggagcgcaag tgctcctgcg ggaagaagtg      540

tcgcggctcc aggaggaagt tcaccttctc cggcagatga aggagatgtt ggcgaaggac      600

ctggaggagt cgcagggcgg caagtcctct gaggtcctct cggccaccga gctcagggtc      660

cagctggccc agaaggagca ggagctagcc agagccaaag aagccttgca ggccatgaaa      720

gctgatcgga agcgcttaaa gggcgagaag acagacctgg tgagccagat gcagcagctg      780

tatgccacac tggagagccg cgaggagcag ctccgagact tcatccgcaa ctatgagcag      840

caccgcaagg agagcgagga tgcggtcaaa gcgctggcca aggagaagga cctgctggag      900

cgtgagaagt gggagctgcg gcgccaagcc aaggaggcca cagaccacgc cacggcactg      960

cgctcccagc tggacctcaa ggacaaccgg atgaaggagc tggaggccga gctggccatg     1020

gccaaacagt ccttagctac gctgaccaag gacgtcccca agcggcattc cctcgccatg     1080

ccgggcgaga cggtgctcaa tggcaaccag gagtgggtgg tgcaggcgga cctcccgctg     1140

accgcagcca tccggcagag tcaacagact ctctaccact cacacccccc tcaccctgcg     1200

gaccggcaag cggtcagggt gagcccctgc cactcccggc agccctctgt catctccgac     1260

gcatctgccg ccgaaggcga ccggtcgtcc acaccgagcg acatcaactc ccctcgacac     1320

cggacacact ccctctgcaa cggcgacagt cccggcccag ttcagaagaa cctgcacaac     1380

cctattgtac agtcactaga ggatcttgaa gaccaaaaac ggaaaaagaa gaaagagaag     1440

atgggattcg gctccatctc ccgcgtcttc gccagaggga agcagcggaa gtccctcgac     1500

cccggcctct ttgatgactc ggacagccag tgcagcccca cgcggcagag cctcagcctg     1560

tcggaaggcg aggagcagat ggaccggctg cagcaggtgg agctggtgag gaccacccct     1620

atgtcccact ggaaggcggg caccgtccag gcctggctgg aggtggtgat ggccatgcct     1680

atgtacgtca aggcctgcac ggagaacgtg aagagcggga aggtgctgct gagcctgagt     1740

gacgaggacc tgcagctggg ccttggggtg tgcagctccc tgcaccggcg caagctgcgc     1800

ctggccatcg aggactaccg tgatgccgag gcaggccgca gcctgtccaa agctgccgag     1860

ctggaccatc actgggtggc caaggcctgg ctgaatgaca ttggcctgtc ccagtactcc     1920

caggcctttc agaaccacct ggttgatggg cggatgctga attccctgat gaagcgagac     1980

ctggagaagc acctgaacgt gtccaagaag ttccaccagg tcagcatcct gctggggatc     2040

gagctgctgt accaagtgaa cttcagcagg gaggccctcc aggagcgccg ggcccgctgc     2100

gagacgcaga acattgaccc cgtggtgtgg accaaccagc gggtgctcaa gtgggttcga     2160

gacatcgacc tgaaggagta cgcagacaac ctgaccaaca gcggcgtcca tggtgctgtg     2220

ctggtgctgg agcccacatt caatgccgag gccatggcca ctgccctggg catccccagt     2280

gggaagcaca tcctccggag acacctggca gaggagatga gcgccgtctt ccacccagcc     2340

aactccacag gcatccggga ggctgagcgt tttggaacgc cccctggcag ggcctccagc     2400

gtcacgcggg caggaaagga ggagaacagc agcggtctca agtacaaggc tggccggctg     2460

cccctgggga agataggaag gggcttcagc agcaaagatc ccgatttcca tgatgactat     2520

ggctctcttc aaaacgaaga ttgcggagac gatgaccccc agagcaggct ggaacagtgc     2580

cgtctggaag gctacaacag cctggaggtc accaacgtgt aaggaactgg tggctccacc     2640

agacccaacg tgagagaccc aggaaggaag agaagccaga tggccccagg tgtcgttctc     2700

actgtacata gcggccgcag gctgaggatg tcccttgctc ctgggcaaaa tcccgatgga     2760

ctctgcggtt tcagctccac agcgcccagg agagagaaga caccagccca cctgtcttgg     2820

gtgggccatg gactttcctg ttcagctgga gatgggccca gaggacctgt cacagtgtcc     2880

ggccctgcct ccatccagga tacacaggct ccacctcaga gtgaccgtca ctgtggagca     2940

gccaagcagt ccctggagcc ttaaacggag ctgccaaggt gggaggaggc ccacagttcc     3000

ctaaaacacc cttccggcgg gagcaggggg gaccccaacc ccacacccca gcgcccagtg     3060

cattggcaga gccgggtgca ggaagtgctg cctcttgccg agacgtcgga cagggcgggg     3120

gttggggaac tctcggctac agcatcttac ccttgactga gaacttgggt cctgacttgg     3180

ctcactgaat ctctcttggg agaatgcaaa atccttccac ctgaaaagct ctgtgacaca     3240

tgggggtgga cgtattgaag agctgtttgc cgatccaccc aggagtggct acgctgagtg     3300

gggagccggt gaatgatccg tgcaggagtg gggcttagca gccacatttc taggagatgc     3360

agatatccta tcaccagaat gaaagctatt gggacaacag gatcggggat gaccgacggc     3420

cccatatggt gaatctctgg cctgtggttt ggctttactg agattccaaa ccccactatc     3480

tgcactccgt gacagtggta tggagtgtgg caatgagttt ggggtctggg gcagggaaat     3540

gcttgacatt gttaacccaa caaacctttg ttgtgatgtc cctgtcacct gaaacatagg     3600

tgacatagct caccaatgtc ctaaccgaga cacaaactcc acagagcaaa atcatttggt     3660

attggtgggg agaaccccag cccttttctt gacctgccac tgttatgctg tgtggcttct     3720

tcccagtggc ctcacctctc tgtgcctcga tgtcttcatc tacgatactt ctggttccct     3780

cccagggaca tcgtgaggat taacacttgc taatatctgt aacacaattt gtaacctctc     3840

aggagacaat gggaagttat ggggtagcta atttcccatt tacaacacag aaatgatata     3900

gagctagttc gctccaactc tttaggttga agcagtgtgc aaaaggaaga aaagaaatgt     3960

ttaatgttca gacctgccaa gagcctccaa cagggctcaa gaaacatata aatcccatga     4020

gcacagcctt gaaaaccagt ttgactcaag ccttcgggcc tcagttcatt gaccagatga     4080

cagccacgtg atgattaggg aaggacggat gcattgcgat tctgcttaca catcgggtta     4140

tcaaagcgag tcacttgttg gaaccatgat gctcgacctc cttcaaggcc gtttgcactg     4200

gggcttgagt ttccaagatt cacaacaggt gtcagcctct gagaaccctc aaagcgtgtg     4260

ttcttcaacc tggcaaattg tttcctctca tgggggaagc cgagctctga tgaacttgag     4320

aattacacct ctctcatgcc gaagaccgtg gtgttccccc taatgacata aacgcagcct     4380

ttcttgctgt ctgagaccaa atgtctagtt ggtagacagg tggatgtttg gcctcctaag     4440

ggcacacttc tgatcctggg ccccaggtgg tgaatctctg gcatgtggct tggctttgtt     4500

gagactccaa attccattat cttcatgaca ttcggcctca tccatagggt cctgaagctg     4560

cagtccacag ctcagaaagg agaggtgaga cctccctcca acctggtgcc acaggtctct     4620

cccaagccac atccagcctg gatgacctgg gaccccagaa actgccgttt gggaggcagc     4680

aacagcaacg tgcccaggca ggcagttatt cccacagagt gagccagaat tgtagcaggg     4740

cacttgaatg cagagctgat gatttgaaac caacgttcac ccaacttgtc agaaatggca     4800

cttacatggt tcgatcttgc tggagacaag tggacaattg ggggtcactg gcagagacag     4860

tattgcccaa aatgttcaca gcaggaggcc agcaggcctg aggcaacacg ggcaaccgcg     4920

aatgcctctt ttggtttaaa ttatgccatc acaaccctct ttcacccatg aggctcccca     4980

tccctgacag ccaggtgagc atttggagct ggtttctcaa catgaggatg ggttggttgt     5040

taaattaaca acctccacag tatcagattg agtgagcttt gtctgctgga aaaacctgaa     5100

acgtcaactc tgcttcaagg tcggcaagaa gaacagaagg cggagacttg gcagagagac     5160

tcaagctgat tgtcacaggc tacagagggg ccagctccag aacagtgacc agctacatcc     5220

tgtccaagca gcccgagtgt ggtcttggtc cctgcagggc aatgtgggca tctggacctg     5280

gggacgatgt ggatgcactt cttggaaagc tgttgtagct tgtgcctgtg ggtggagaag     5340

gcacctgcct ggtagactct cagctttctg acccccagga gcctctgcga ggcccctttg     5400

tccttggctg agccggacct ttcttttgga aatctgtctg tctgttggca tcgctgtttt     5460

cagaccccag gctgcagagg aggggagaag ccacacaaca atctggaccc aataaagtgg     5520

agagaagggc gtctctacac agcccggcca gcgtggaggg ccccaggaca gggacccaaa     5580

agcttgacgt cactgaacag ggctgggtac tggcagaaca ggaagatttg gccagaggtg     5640

acctcagtgt tccctccagg ggcatccagg cccctctgac ctggggagaa gaaggcccat     5700

gctcaggccc acctccctct tcccatcaga gcccatgcgt cctgggcacc accacttcca     5760

ctctgctttt cgaggctccg gagggctctt cctgctgtga aaggaaagga gaagaaagcc     5820

tgtgggcaat ggcaacctct gagtctggca ttcttgccaa tggctggcca gcgaggagaa     5880

tctcccgagc cctgacacac aaaggcattt tgtggctgca gaggaaatgg gttggctctg     5940

aacaaagatg cagtttctag ggccgtggcc ccaaatcgct tccccgagag tgaattttaa     6000

cactgtaaca ataaatacta ctgcacagca                                      6030


<210> 1976
<211> 1030
<212> DNA
<213> Homo sapiens

<400> 1976
ggggaatcac ttgcaaggtc cacacaagtc cgcctatgta ctctctggat cgaatatttg       60

ctggatttcg aacacgaagt cagatgctgt tgggtcacat agaagaacaa gataaggtcc      120

tccactgcca attttctgat aacagtgatg atgaagaatc agaaggccaa gagaaatctg      180

gaactagatg tagaagtcgt tcatggattc agaagccaga ctctgtttgt tcccttgttg      240

aattgagtga tactcaggat gaaacacaaa agtcagattt ggagaatgaa gatttaaaga      300

ttgattgtct ccaggagagt caagaattga atttgcaaaa attaaagaat tcagaacgca      360

tacttactga agctaaacaa aaaatgagag aacttacaat taacatcaag atgaaggaag      420

atctgattaa agaattaata aaaacaggta atgatgccaa gtctgtaagc aagcagtatt      480

ctttgaaagt aacaaagcta gagcatgatg cagaacaggc aaaagtcgaa ctgattgaaa      540

cacaaaagca gctacaggag ctggaaaaca aagatctttc tgatgttgca atgaaggtaa      600

aattacagaa agagtttcgt aaaaagatgg atgctgcaaa gctgagagtt caggtcttgc      660

agaagaagca acaagatagt aagaaactgg catcactgtc aatccaaaat gagaaacgtg      720

ctaatgagct agagcagagt gtagatcaca tgaaatatca aaagatacag ctacaaagaa      780

aactacgaga agaaaatgaa aaaaggaagc aactggatgc agtaattaag cgggaccagc      840

aaaaaatcaa agtaatattg tcatacattc ctgctaagta taatatgaaa tgttaaacgg      900

ctcagagcta acgaatccat ggtcttcatt cagttggctt gtgaagtatc tatccttgac      960

ctgcccttca ctgctgtcct tattcacttt aaagctttgt tcatctacgt agtaaaacct     1020

acttattgaa                                                            1030


<210> 1977
<211> 6243
<212> DNA
<213> Homo sapiens

<400> 1977
aggtggcagc gcttgcagtc gggctacgga ggccgggttg ccagattacg ggaaagccat       60

ttaagaagtt cctggaataa tattagtcag agtaatatag gatctgcagg aagtgtctca      120

agatagttgg aaaagaagaa tttctagact cttcatcaag atcttcattt atacagctgt      180

taaatccaag gctactttgg tgaaagcatg aataaaaata catctactgt agtatcaccc      240

agtctacttg aaaaggatcc tgcctttcag atgattacaa ttgccaagga aacaggcctt      300

ggcctgaagg tactaggagg aattaaccgg aatgaaggcc cattggtata tattcaggaa      360

attattcctg gaggagactg ttataaggat ggtcgtttga agccaggaga tcaacttgtc      420

tcagtcaaca aggaatctat gattggtgta tcatttgaag aagcaaaaag cataattacc      480

ggagccaagt tgaggttaga atctgcttgg gagatagcat tcataagaca aaaatccgac      540

aacattcagc cagaaaatct gtcatgtaca tcacttatag aagcttcagg agaatatgga      600

cctcaagcct caacattaag tcttttttct tctcctcctg aaatactaat cccaaagacc      660

tcatccactc ccaaaacaaa taatgacatt ttatcttctt gtgagataaa aactggatac      720

aacaaaacag tacagattcc aattacttca gaaaacagta ctgtgggttt gtctaataca      780

gatgttgctt ctgcctggac tgaaaattat gggctacaag aaaagatctc cctaaatccc      840

tctgttcgct ttaaggcaga gaaactggaa atggctctaa attatcttgg tattcagccc      900

acaaaggaac aacaccaagc cctgagacag caagtacaag cagactcaaa agggacagtg      960

tcttttggag attttgtcca ggttgccaga aacttgtttt gcttgcagtt ggatgaagta     1020

aatgttggtg cacatgaaat ttccaatata ttagattcac agcttcttcc ttgtgattct     1080

tcagaagcag atgaaatgga aaggctcaag tgtgaaagag atgatgcctt gaaagaagta     1140

aatacactta aggaaaaatt attggaatca gataagcaaa ggaaacaatt gacagaagag     1200

ctccagaatg tgaaacaaga agccaaagct gtagttgaag aaacaagagc cctgcgtagt     1260

cggattcatc ttgctgaagc tgctcagaga caggcacatg gaatggaaat ggactatgaa     1320

gaagtgatcc gtctgttaga ggccaagatt acagagctaa aggctcagct tgctgattat     1380

tctgaccaaa ataaagaaag tgttcaggat ttaaaaaaga gaatcatggt actcgactgc     1440

caattacgaa aatcagaaat ggctcgaaaa acttttgagg catccactga aaagcttctt     1500

cattttgtag aggctattca agaagtattt tctgataatt ctactccttt atcaaattta     1560

agtgaaagaa gagctgtgtt agcttctcag acttccctca caccactggg aaggaatgga     1620

cgtagcatcc cagcaacgct ggcgcttgaa tctaaggaac ttgttaaatc tgttcgtgcc     1680

ttacttgata tggattgttt accttatggg tgggaggaag cttacacagc agatggaatc     1740

aagtacttca tcaatcatgt aacacagact acatcctgga tccatcccgt gatgagtgtc     1800

ctgaatctat ctcgctcaga ggagaatgaa gaggattgct ctagagaact ccccaaccag     1860

aaaagttgat ggttttcctt aggaagtgga gctacatgga tgatgtgagc agagacgcat     1920

aacatccaat tctgagatga aacagtctaa aataggagta aagcatgcac tacttgttga     1980

agtgtgaaat ggagactctg gactttgggt atttttgtaa aacttttgat atttctgtat     2040

acatttaaaa aatcaattgc cactacagta gttccttaag aataatctag ttatattttt     2100

tgaaatcaca tataattaga ctttataata tatatacttt ttcatatata attagatctt     2160

tctttgtaat ttcatatgta gttcttcata gggtctcaga tacaatggtt tttataattg     2220

acatattgaa aaagtatatg aacataatga aacacctcat ttatttgata attcactaat     2280

gttttatatt catatattag gaaagtgaac ttagcaagct ttttggaatt taaggatcac     2340

atttagacat ctcatgggct gatgaataca gctggtatct ttgtggagct ttctaattta     2400

caaaatgctt tgtagacccc attgtcttta aaccatacaa catgcccgtg aagctgatct     2460

ggtgggtatg tttattcttg gttttcagta gggaaatagc agttcagaga gaggaagctc     2520

tctgtcccag caccgagact cactcctaag tcttctgatt ccatgagcag tcccccttcc     2580

cccataccct gctgtctcca cggagggagg tcacagccca tcacgcagga cactgtgatt     2640

gtgttgatgc agctggctcc acagctgtgc attccacaga gattcagaag gcacctcttc     2700

ggtcaaacat ggcccctcta taaccccact attcttctcc tataaaccct tcccccttct     2760

ctgcacccaa gccttcgcca agtaggcgca ctctttgtga tattgtttca gcagacttct     2820

ttcagcagct cgtgtttttc taaagtgaaa ggcatggttt gtcctgctta ggttgccctt     2880

cccagaggga tggtttgagg ggagctgatg agaagagagg tatctgttaa aacattactg     2940

ctctactcga aacaagatgg aagcctaaag cccaagtcga gcagctccca gcactgctgt     3000

gcagacctag aggtccttag aacatagtct aagaaccatt cattgtagcc attttatagt     3060

tgagtaaact gagatcttaa gtctcctagt ctactgaatt tcatatggtg tataatacag     3120

atttatatgg taaagatata catatacatt gtgctcaact atacattcct gaatccattt     3180

aggatttgtg atttatgtct tgagtaataa tataaagtca actccagact gataggtagt     3240

cattagccat gagaaatgtt tcaggatggc tagggaagac ttgtgttttg cctgacagcc     3300

atttgaatgt taggaagctt cggggagaca agttttgaga gaagccccag agggagctat     3360

ttccttgcac cccccagagg tgaatgaggt attctataag ttagtgtcta taattgtgaa     3420

agtacaaact tcttgttttt gtcaaattaa tggtatgaaa tttctctccc cctgcttgaa     3480

gagttttcta attcgtttct agtgagcaaa acaaagaagg tgcttgagtc actgaaatca     3540

aagtactcag gcacacagcc cactgacaag agacacctca tccattaact gctgttttgt     3600

accacttgcc gccctgtttc tgtcaaatac ctagtgaaaa aggcctaaac aattgtaatg     3660

atattattta ttgggcattt tgtgccatac atggtgatga gcagtttgca tatatttatt     3720

tatgatcttc ttaaaaccat tccatgaaat aggaactgta attatcccca attctaaaag     3780

aaaaaactta gttttagaga gttagtaatc tttgcctaag ggtcacaaag cacctatgtg     3840

tagaagctag ggttcaaggc agatctgtga ttccagaagc tgttctctaa accactatgg     3900

agaactgctt agattcattg tctatgggta cattttataa aaaggcagat tctagttcag     3960

tgtcataagg aactttctag taattagagc tgataagaaa agaattcccc aggagaaaat     4020

ggaaacacta tcccagcaat ctgaattcct tacttgggga atgttgctga ggaggttcag     4080

tgtgtgaatg gactgaacca gttggccact ctctcagatt ccctcttcat aaagcttccg     4140

tgacttctaa accatcaggt cggtgccata agagatgctc aaaaaagcat ggtcagggct     4200

tagcaagaat ccttttccag tgcaaatacg accctcatat tatgttttgg cgagtagcca     4260

gtctttcttt aacatcaatc aaccgtagca atgtggtcat cacgaagtct tcattgactc     4320

actggcttgg attttagggt tagaaaatct gaatgttctt atgtccttcc gtctcacttt     4380

actagagtgc ccaagttgac tcatccttac tcactcattc cctcaaaata tttattgagc     4440

accaacaatg tcacaagcac tgtgctaaac actgtggtga agtagaacaa ttgctaatca     4500

tttcctgggt tccacttact cttgatttaa aaaaaaaaaa acaacaaaag agtttgtgtg     4560

tggccaggac taaacagctg cttcttaatt tttgaatttt aaaactaatc tattttattt     4620

aaaaaaaatc aagtactttg gaagtgaata aagtaagaga tagcctgtct cactttccag     4680

aggtagcagt cactaatact gtggtgagtg attttactca aaggaaatca cactattaag     4740

cagcttggtt ttgacatgtt atgttgtggt catcttttca tgtcaataca tagattaatc     4800

ttttatttca aatgtctaca taaaatatca ctacccacat aacctataat ttgtgtggcc     4860

agcaatttat tgaacactaa aatgttttaa gttttcttat tgctaacaat gtcacagtga     4920

acatttatat attcattaaa tccttttcct catgtatctt tgcactcttg tgctagtatg     4980

tctatagtgt gaatacattc ataaatttct tgatcaaagc taggtcaaag ttacattcat     5040

tttaattttg gtacatatcc ataaattctc cataaaagta ggaccaactt acattaccac     5100

caatagtgta tgtgagcctt atttttatgt atgataggac tttttttagt ccaaatgttc     5160

ctatagattt tctgggtttt tttttttttt ttgtccttgg aagaataacc ttccttccac     5220

caagtccaag aacctgagat ttttaatcat taggttttag atttccttta gcagcagaga     5280

ctgacttgct gtatagaggg aagtcaagta gtgactaact cactatatgt caaacacatc     5340

attactcttc tcttttccta ctttacatgt aatggttgcg aggaccaact ttcaaatgag     5400

ctaacttggg tgagacgttc actaaagtac caagcacaat acaaatgcat cttcgagttc     5460

tttgggcctc actttcccta tctgaataat aaggatagta atcccttgcc ttttctcaaa     5520

ccagttcaac tcagcaaaca cttcctgagc acctgctaca tgccaggcaa aatgtgaaat     5580

ttgcatgcta tgaggctaaa tggtactgat tctcaaaaca aggagctcat agtctaaaac     5640

catttttctt tctttttttt ccccctaaac aacctcttaa aggggtaaga agttaggggg     5700

ttgtttatta agaacccctg aagagcaacc ctttaccact ctcttaaatt tgaaaaattc     5760

caaaataata ttaacacctc ttgactagaa aaggaaaaaa aaggaacatg ccgtatgaag     5820

agcctctcca ataataaatg caaagcagct gtcaaaatat agagtcaagt gatactttca     5880

taaagtgttt gcacaattag aaaatgttat cctttttctc gggagaaatg ggacattttt     5940

attttctctg ctaagtgaaa tgcaactttt tgaagaatca acacgcttga catttttaca     6000

atgtacataa agaactgaac tattattaaa acaacttaca cactccattg cttataactt     6060

ttgagagaat gaaaagaacc ttaaacagaa tgtgcctgtg gagcttcgct ttagaaatga     6120

aatacccaag gtgttttaac tacaactgtc tacatgtaat agtgtgtctg cataatgact     6180

ttgtaaatat taactgcaat tctgtatttg ctttcttgat atgactttta acatttaaac     6240

tta                                                                   6243


<210> 1978
<211> 692
<212> DNA
<213> Homo sapiens

<400> 1978
ggttatggcg gcgccgggcg cgctgctggt gatgggcgtg agcggctcgg ggaaatccac       60

cgtgggcgcc ctgctggcat ctgagctggg atggaaattc tatgatgctg atgattatca      120

cccggaggaa aatcgaagga agatgggaaa aggcataccg ctcaatgacc aggaccggat      180

tccatggctc tgtaacttgc atgacatttt actaagagat gtagcctcgg gacagcgtgt      240

ggttctagcc tgttcagccc tgaagaaaac gtacagagac atattaacac aaggaaaaga      300

tggtgtagct ctgaagtgtg aggagtcggg aaaggaagca aagcaggctg agatgcagct      360

cctggtggtc catctgagcg ggtcgtttga ggtcatctct ggacgcttac tcaaaagaga      420

gggacatttt atgccccctg aattattgca gtcccagttt gagactctgg agcccccagc      480

agctccagaa aactttatcc aaataagtgt ggacaaaaat gtttcagaga taattgctac      540

aattatggaa accctaaaaa tgaaatgaca atgattttgt atcagtggtc caaacagaac      600

taagcataaa tcattgtgcc atcccaaacc tcgttccagc cgccttgccc atactagatt      660

ctaaatgttt ctaaaggcaa accccaatgt gt                                    692


<210> 1979
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 1979
atggccacca tcccagactg gaagctacag ctgctagccc ggcgccggca ggaggaggcg       60

tccgttcgag gccgagagaa agcagaacgg gagcgcctgt cccagatgcc agcctggaaa      120

cgagggctcc tggagcgccg ccgggccaag cttgggctgt cccctgggga gcctagccct      180

gtgctaggga ctgtagaggc tggacctcca gacccggatg agtctgcggt ccttctggag      240

gccatcgggc cagtgcacca gaaccgattc atccggcagg agcggcagca gcagcagcag      300

caacaacaac ggagtgaaga gctgctagca gagagaaagc ctgggcctct ggaggcccgg      360

gagcggagac ccagccctgg ggagatgcgg gatcagagcc ccaagggaag agagtcaaga      420

gaagagagac taagtccgag ggagaccaga gagaggaggc tggggatagg gggagcccaa      480

gagttgagcc tgaggcctct ggaggctcgg gactggaggc aaagcccagg agaggtggga      540

gacaggagct cccgactgtc agaggcatgg aaatggaggc tgagtcctgg agaaactcca      600

gagcggagtc tgagactagc agagtctcga gagcaaagcc ccaggagaaa agaggtggaa      660

agtagactga gcccagggga atctgcctac cagaagttgg gcctgacaga ggcccataaa      720

tggagacctg actccagaga gtctcaggaa cagagtttgg tacaactgga ggcaacagag      780

tggaggctga ggtcaggaga agaaagacaa gactactcgg aagaatgtgg gagaaaagaa      840

gagtggccag ttccaggggt agctccaaaa gagactgcag agctgtccga gaccctgaca      900

agggaggccc aaggcaacag ttccgcagga gtggaggcag cagagcagag gcctgtggaa      960

gatggcgaga ggggcatgaa gccaacagaa gggtggaaat ggaccctgat aatgagcctg     1020

gcagggaagg gcaaccaaca tcttgtaact tgctttcccc accctgtttc tgggggcaga     1080

gccaattgcc caatttctac cctaatccaa agtccctggt gtgggtgggg ttaa           1134


<210> 1980
<211> 5576
<212> DNA
<213> Homo sapiens

<400> 1980
ctccttggcg gtgcctggag cccgggcgca ccccaccgct cccgggacct gttgggggct       60

ggcccgaacc gtcgtcgaag ggagccgctc ggccaccccc gacgttcctc gccccgcccg      120

acgttccctc aagtggccga accagccgga cgagccaaac tcgccgggcc tcccggcggc      180

agcaggtggc cccgtccttc cagggagggc cctgcgcccc gcggcgctcc ggagccctct      240

cggccgcccc cgccaggcgg gatggaggcg gatggggacg gagaggagct ggcccggctg      300

cgctcagtct tcgccgcctg cgacgcgaac cgctcggggc gcctggagcg cgaggagttc      360

cgggcactgt gcacggagct gcgggtgcgg ccggccgacg ccgaggcagt attccagcgg      420

ctggacgccg accgtgacgg cgccatcacc ttccaggagt tcgcgcgtgg cttcctcggg      480

tccctccgcg gggggcggcg ccgggactgg ggtcctctgg atcccgcgcc cgccgtgtct      540

gaggcggggc cggagacaca cgacagcgag gaggacgaag gcgacgagga cgcggcggcg      600

gcgctggcca cctcgtgcgg cccggcgagt cccggccggg cttggcagga tttccaggcg      660

cgacttgggg acgaagccaa gttcattccc agagaagagc aagttagtac cttgtaccaa      720

aacatcaacc ttgtggagcc aagattaatt cagccatatg aacatgttat aaagaacttc      780

atccgtgaga tcagacttca aagcacagaa atggaaaatt tggccattgc ggtgaagaga      840

gcccaggaca aggcagctat gcagttgagt gagttggaag aggaaatgga tcagaggatt      900

caggctgcag aacataagac acggaaagac gaaaaacgca aagctgagga agccctcagt      960

gacctcagac gtcagtatga aactgaagta ggagatctgc aggtgaccat taaaaagcta     1020

agaaagctcg aagaacaatc aaaacgcgta agtcaaaagg aagatgtggc tgcattgaaa     1080

aaacaaattt atgatttatc aatggaaaac cagaaagtta agaaagacct tttagaagca     1140

cagacaaaca tagcctttct tcagagtgag ttagatgctt tgaaaagtga ttatgctgat     1200

cagagtctga atactgaaag ggatctggaa ataatccgag catacacaga agatcgaaat     1260

agtcttgaga ggcaaattga aatactccaa acagctaacc ggaagctaca tgacagtaat     1320

gatggcctta gaagtgccct tgaaaacagt tatagcaagt tcaacagatc tttgcatata     1380

aataatatct caccagggaa tacaatttct agaagcagtc ccaaattcat tggtcattcc     1440

cctcaacctc taggctatga caggtcatcc cgctcttcct atgtggatga ggactgtgac     1500

tccctggccc tctgtgatcc tctgcagagg acaaattgtg aagttgacag cctgcctgaa     1560

agctgcttcg acagcggctt gtctaccttg agagatccca atgagtatga ctcagaagtg     1620

gaatacaagc accagagggg atttcagagg tcacacgggg tgcaggagag ctttggaggt     1680

gatgcttcag acacagatgt tcctgacata agggatgaag agacatttgg tttagaagat     1740

gtggcttccg tcttagactg gaagccccaa gggtctgtta gtgaaggcag cattgttagt     1800

tcatcaagaa agcccatctc agcactctcg ccccagacag acctggtaga tgacaacgct     1860

aaatctttta gctcacagaa ggcttacaag attgtacttg ctggggacgc tgcagtgggg     1920

aagtctagtt tcctcatgag actttgcaag aatgaatttc gagaaaatat aagcgccacc     1980

ctgggagttg atttccaaat gaaaaccctc attgtggatg gagaacgaac agttctgcag     2040

ctctgggata cagctggtca ggagagattc agaagtattg ccaagtctta cttcagaaag     2100

gcagatggtg ttttgctgct gtatgatgtt acatgtgaga aaagctttct taacatacga     2160

gaatgggtag atatgattga ggatgcagcc catgagactg ttcccattat gctggtagga     2220

aacaaggctg acattcgtga cactgctgct acagagggac aaaaatgtgt cccagggcac     2280

tttggagaga aactggccat gacgtatggg gcattattct gtgaaacaag tgccaaagat     2340

ggttctaaca tagtggaggc tgttctgcac cttgctcgag aagtgaaaaa gagaactgac     2400

aaggatgaca gcagatccat taccaatcta accgggacca attccaaaaa gtcaccacag     2460

atgaagaatt gttgcaatgg ctaaatccca aacatccttg gcctgtgaag tcttcatttc     2520

cagaatactg aatttgtgtg acttatttgg ctcttaacag agtggcacat cctactgaca     2580

ctgtcctatg gagagttaca gtgcaggaaa cctgaaccca gctctcaggt ccctctggaa     2640

ctttggctct tctttgtttt gtctcagtga gtgatttggg ccctctggct aaatagacta     2700

gtcatgtcct tacaggtctt aaaagataac atgtaaatgt ttttaaaatg gtaaaaaaaa     2760

agaaaagaaa agaaatcaca tgctcagatc aaagctgtag aggaaactga cataattaga     2820

ttcatgtggt agctgaatta ggttacccac aaagtcagca tttaaatatt tgatactaaa     2880

gttctagtaa gaagggattc tcatcctagc tttgctgtta actggccttg tgaccttgga     2940

catgtcacaa gcccatgtcg gatctgtttc ttcatctgta aaatgtgcag cttgccctca     3000

aaggccttgc agcccttggc acctcagatt ctgtgggaag cagtaggaca gagagtgtgg     3060

tggcccacag ttaataatag aactatggtt attcctgctt tttaatattg gagtattgat     3120

ttttctcact tctgaaataa ggacagaatt tgattaaaaa atggaaacag aaatatctat     3180

tttttatgta taaagaaaca tgtttgagac aaaaatagtt gtatataaaa ggatatttca     3240

taatctcaga atagttacaa agctcactgc ttgaatttgg tgttaaaaat tctaatggaa     3300

acatgtaaag ccacatacta ctgaaagcac aatgcccagg aaagttgtca ctcttcactt     3360

aagggagtgg ttgccagggg ctgagaaagg gaggatgggg agtgactgct aataggtatg     3420

tggtttcttt gggcgatgat gagaatgttc tggaattgga atagtggtga tagttgtata     3480

actgtttgaa tgtactagga accactgaat tgtatacttt gaaagggtga attttatggt     3540

tgtgaattat ctcactaaaa aaaatgctag tacttagagt gatgtaacat tttgcaaaat     3600

tttcattttc gtatccctgc tgatttcaaa ccttcccatg gtttagaagc ataacctgta     3660

atgtaatgca agtcccctaa ctccctggtt gctaacatta acttccttaa gtaataatca     3720

atgaaagaaa ttctatgcat ggttttgaaa taatatcctt gaaagaggaa tcaccattag     3780

gaaaggtgag tcagggtcct ttgtttaatg tgactagtgg ctcatcatca ccagtgacct     3840

ggttgggcct actctccttc cagaacctgc attgcttccc agacctcccc actgagatgc     3900

ctctaagagc caaaggagtc aacacttgag cctagggtgg gctacaacaa aagattctaa     3960

tttaccttgc ttcatctagg tccaggcccc aagtagcttg ctgaaggaac ttaaaaagta     4020

gctgttattt attgtattgt ataagctaaa aacatttatt tttgttgaat cgaaacaatt     4080

ccatgtagca atcttttttc tgttcacggt gtttgtgata gaaccttaaa ttccgcaagc     4140

atcagttttt tgaaaaaatg ggaattgacc ggatagttac aggcaaagat tataaatagc     4200

tacaacatca tttaactttt ataaacatgc cttctctcta ttgaagacat ctgatatttt     4260

tgctggaaag ttggatctat cctcagtaac tctgccatga attcctgttt cctggttcca     4320

gaaaaagaaa agattacatt tctgatcata aagaatgtct tgcatatggg aaatttttca     4380

aaataagggg ggtattattt atgtggcatg ggaaaacttt tgccatggct gtttgtctta     4440

gtggcatctt ttgatgacat tggatcagat atatgtagat gctgatatat gggacacatg     4500

tttaggtttt ggtgcagttg cacaaaactg tgttagttta tatgttactg tgttgccttt     4560

atttattctc tccaaagtgt ctctttatat ttgttttaca atctgtgaaa gagtatacca     4620

taatacagaa gtattttcat agtctttacc tctggattgt cctgtcagta tagccacgtt     4680

gatgagatta caccagtgcc tttgatggtc aaccaatcat ctttaagtat ttgagccctg     4740

ataaatattt tggtaacata atccaaatta gagacttaga gctctggtta gcaatcatgt     4800

ttaaagagaa gcttcttaaa gctctgtatg ctgggagatt catgattatt accaacgttt     4860

tgatttcatg aaggtgttct caaatttaaa gcacattttc agtaagaaca aaaatattta     4920

atgtttttat cttagacttg atacatttgc atattactat ggaagttatt caccttgtcc     4980

ctgtttttct ttaagatatt ttaaaatcat agttatacta cagtcctttt ttaaatgtat     5040

cctgatacat tgtaaaatat tttaatttca ttgtggaaaa taatgttgga taaggagata     5100

tttttcactg ttaactttta gcccatgcat tttcataatt tatttttttc acttgctgct     5160

ttatatgaca tatgtgacat ttgattattt aacacttgat gtgatctgca taaacccaag     5220

ttgcacaacc ctcctgctga agataaaatt gaggttaaag ataaagattt attttcatat     5280

ttgtacagtg atcggcttca gtgatggttt ttgtgggcat ttattgtgtg tgtgtaagaa     5340

atttcatatg tatatattaa gtaggcctct gagtattgaa taattgtttt atgattttga     5400

tttatatggt ttacattttc attgtgtggg ccatatttcg tttatactgt ttatttctct     5460

tcaaacctta ataattatac cataaagtgt aatttttata gcaatgcaaa tgtctaagga     5520

actacaaata ttttctacgt tgtaaattca ataaagcttg cttcctttgg cctttt         5576


<210> 1981
<211> 5520
<212> DNA
<213> Homo sapiens

<400> 1981
cttttgcggc aggcagagac aatggaagaa aatgaaagcc agaaatgtga gccgtgcctt       60

ccttactcag cagacagaag acagatgcag gaacaaggca aaggcaatct gcatgtaaca      120

tcaccagaag atgcagaatg ccgcagaacc aaggaacgcc tttctaatgg aaacagtcgt      180

ggttcagttt ccaagtcttc ccgcaatatc ccaaggagac acaccctagg ggggccccga      240

agttccaagg aaatactggg aatgcaaaca tctgagatgg atcggaagag agaagcgttc      300

ctagaacatc tgaagcagaa gtacccccac cacgcctctg caatcatggg tcaccaagag      360

aggctgagag accagacaag gagccccaaa ctgtctcaca gtcctcaacc acccagtctg      420

ggtgacccgg tcgagcattt atcagagacg tccgctgatt ctttggaagc catgtctgag      480

ggggatgctc caaccccttt ttccagaggc agccggactc gtgcgagcct tcctgtggtg      540

aggtcaacca accagacgaa agaaagatct ctgggggttc tctatctcca gtatggagat      600

gaaaccaagc agctcaggat gccgaatgaa atcacaagtg cagacacaat ccgtgctctc      660

ttcgtaagtg cctttccaca gcagctcacc atgaaaatgc tggaatcgcc cagtgtcgcc      720

atttacatca aagatgaaag cagaaatgtc tattatgaat taaatgatgt aaggaacatt      780

caagacagat cactcctcaa agtgtacaac aaggatcctg cacatgcgtt taatcacaca      840

ccaaaaacta tgaatggaga catgaggatg cagagagaac ttgtttatgc aagaggagat      900

ggccctgggg cccctcgccc cggatctact gctcatccac cccatgcgat tccaaattcc      960

ccaccgtcta ctccagtgcc ccattccatg cccccctccc cgtccagaat tccttatggg     1020

ggcacccgct ccatggttgt tcctggcaat gccaccatcc ccagggacag aatctccagc     1080

ctgccagtct ccagacccat ctctccaagc ccaagcgcca ttttagaaag aagagatgtc     1140

aagcctgatg aagacatgag tggcaaaaac attgcaatgt acagaaatga gggtttctat     1200

gctgatcctt acctttatca cgagggacgg atgagcatag cctcatccca tggtggacac     1260

ccactggatg tccccgacca catcattgca tatcaccgca ccgccatccg gtcagcgagt     1320

gcttattgta acccctcaat gcaagcggaa atgcatatgg aacaatcact gtacagacag     1380

aaatcaagga aatatccgga tagccatttg cctacactgg gctccaaaac accccctgcc     1440

tctcctcaca gagtcagtga cctgaggatg atagacatgc acgctcacta taatgcccac     1500

ggcccccctc acaccatgca gccagaccgg gcctctccga gccgccaggc ctttaaaaag     1560

gagccaggca ccttggtgta tatagaaaag ccacggagcg ctgcaggatt atccagcctt     1620

gtagacctcg gccctcctct aatggagaag caagtttttg cctacagcac ggcgacaata     1680

cccaaagaca gagagaccag cgagaaaatg atgaaaacca cagccaacag gaaccacaca     1740

gatagtgcag gaacgcccca tgtgtctggt gggaagatgc tcagtgctct ggagtccacg     1800

gtgcctccca gccagcctcc acctgtgggc acctcagcca tccacatgag cctgcttgag     1860

atgaggcgga gcgtggcgga actcaggctc cagctccagc agatgcggca gctccagctg     1920

cagaaccagg agttgctgag ggcaatgatg aagaaggccg agctggaaat cagtggcaaa     1980

gtgatggaaa caatgaagag actggaggat cccgtgcagc gacagcgcgt cctagtggag     2040

caagagagac aaaaatatct tcatgaggaa gagaagatcg tcaagaagtt gtgcgagttg     2100

gaagactttg ttgaagactt gaagaaggac tccacggcag ccagccgatt ggttactctg     2160

aaagacgtgg aagacggggc tttcctcctg cgtcaagtgg gagaggctgt agctaccctg     2220

aaaggagaat ttccaacctt acaaaacaag atgcgagcca tcctgcgcat agaagtggag     2280

gccgtgcggt ttctgaagga ggagccacac aagctggaca gtctcctgaa gcgtgtgcgc     2340

agcatgacag acgtcctgac catgctgcgg agacatgtca ctgatgggct cctgaaaggc     2400

acggacgcag cccaagccgc acagtacatg gctatggaaa aggccacagc cgcagaagtc     2460

ctgaagagtc aggaggaggc agcccacacc tccggccagc ccttccacag cacaggtgcc     2520

cctggcgatg cgaagtcgga agtggtgcct ttgtccggca tgatggttcg ccacgcgcag     2580

agctcccctg tggtcatcca gccctcccag cactccgtgg ccctgctgaa ccctgctcag     2640

aacttgcctc acgtggccag ctccccagcc gtcccccagg aagcaacctc cactctgcag     2700

atgtcgcagg ctccgcagtc cccacagata cccatgaatg ggtctgccat gcagagcttg     2760

ttcattgaag aaatccacag tgtgagtgcc aagaacaggg cagtgtctat cgagaaagca     2820

gaaaagaaat gggaggaaaa aaggcaaaat ctggatcact ataatgggaa agagtttgag     2880

aagctcctag aagaagctca ggccaatatc atgaagtcaa taccaaatct ggagatgccg     2940

ccagccacag gcccactgcc aaggggagat gccccagtgg acaaggtgga actttcagat     3000

tctccaaatt cggaacagga cttggaaaag ctggggggaa agtcgccccc tcctcctccg     3060

ccacctcctc gtcgaagcta cctgccagga tcgggactca ccaccacgag gtcaggcgat     3120

gtggtctaca ccggcagaaa ggagaacatc accgctaagg caagcagtga agatgctgga     3180

ccaagcccac agaccagagc tacaaaatat ccagcagagg agcctgcttc agcctggacc     3240

ccatccccac cgcctgtcac cacctcctcc tcaaaggatg aggaggaaga agaagaagaa     3300

ggagacaaaa taatggcaga actccaggca ttccagaagt gttcctttat ggatgtaaat     3360

tcaaacagtc atgctgagcc atcccgggct gacagtcacg ttaaagacac taggtcgggc     3420

gccacagtgc cacccaagga gaagaagaat ttggaatttt tccatgaaga tgtacggaaa     3480

tctgatgttg aatatgaaaa tggcccccaa atggaattcc aaaagggctc cagcggggcc     3540

ccacagacga gcaggatgcc tgtccccatg agtgccaaga acagacccgg aaccctggac     3600

aaacccggca agcagtccaa actgcaggat ccccgccaat atcgtcaggc taatggaagt     3660

gctaagaaat ctggtgggga ctttaagcct acttccccct ccttacctgc ttctaagatt     3720

ccagcccttt ctcccagctc tgggaaaagc agttctctgc cctcttctag tggtgacagc     3780

tctaacctcc ctaatccacc tgctactaaa ccatcgattg cttctaaccc tctcagcccc     3840

caaacaggac cacctgctca ctctgcctcc ctcatccctt ctgtctctaa tggctctttg     3900

aagtttcaga gcctcactca tacaggtaaa ggtcaccatc tttcattctc accgcagagt     3960

caaaatggcc gagcaccccc tcctttgtca ttttcctcct cccctccttc tcctgcctcc     4020

tccgtctcac tgaatcaagg tgccaagggc accaggacca tccatactcc cagcctcacc     4080

agctacaagg cacagaatgg aagttcaagc aaagccaccc catccacagc aaaagaaacc     4140

tcttaaaggt caaatcctat taggcacaag tcggagttac atttaaaaaa aattaacagt     4200

ctacaacaac tgttttcaca agagaatgta acatattgct gtatcgtttg aggcttaatg     4260

ctaaatatgt gctaaatact ggattaatag atttcagtaa agctcgttcg ttttgtttgg     4320

ttttcttttt acctagttgc tatagtgtct acagtctata ctcaatacct ataaaatgca     4380

gtaagcatgt gttacagaaa gaggttctgg tgggagagaa aggtgcgtgt gagacaggag     4440

aattgtctta agcatataaa acatgtatga ttccagaatt ttagtatgtt ttgtataaaa     4500

ctatttttca ttacggagac tagaagtgaa cagagaatta cacaagtgtg actatacaaa     4560

ttgtaaaaca gatactataa tatttccttt tattttagtg ttatttagct ttattacaga     4620

tttctatttt tgtcaaaact tcatggttcc tttcaagatc ttttttgcca aaacattttg     4680

atactatagc attgtacatt tgaaagtagt gttctagact ataaaaccaa tgaacttcta     4740

catgagccct acagacaggc atgtgtagaa ggcaatttat caaacctatt gcactgccat     4800

gaaaagtgtg tataataatt tgctagccca agcaagctag ttttctttgc ttgcttcttt     4860

tctttctttt ttccttcctt tttttttttt ttttcttttt taacatgttg agattctcta     4920

gttgttttct ttggcgtatc taaccccttc ttttgttttc tgagacctgg taacccacgc     4980

tcttgcattg tggattttaa aatgtatact ctgtacggtt ctgtaaaccg aaaaactttt     5040

gtaaatatat aaatatacat agacataaaa atactgtatg tgacagcaca tagagtagtt     5100

ttcccacacc aaagttaatt tttatgcatg ctttaaaagt atatatcggg accggcagaa     5160

atggaagtat ccatacattt ttaaaaagca acaagtttgc acagctagag tgtttttgta     5220

aataaatgta tttgtataac acagtcatgt aatatacaga actataagca gagactttgc     5280

aaaactaaat aaagggctgc atgcttatta ttttttgtac cttgtcacta taactacttc     5340

ctagtcaaag aacgaaatgt aactgttacc gagttaaatg tttttccgct ttgagggatg     5400

taaccacatc cactcagagg acactacttt tctgaaagct ctggggtgac taatgatgag     5460

ttcctaataa attaattgca agtgtggtgc cttggatgtg gcctgttggc tcgctttctt     5520


<210> 1982
<211> 7381
<212> DNA
<213> Homo sapiens

<400> 1982
agcgaggagc ttttgcggca ggcagagaca atggaagaaa atgaaagcca gaaatgtgag       60

ccgtgccttc cttactcagc agacagaaga cagatgcagg aacaaggcaa aggcaatctg      120

catgtaacat caccagaaga tgcagaatgc cgcagaacca aggaacgcct ttctaatgga      180

aacagtcgtg gttcagtttc caagtcttcc cgcaatatcc caaggagaca caccctaggg      240

gggccccgaa gttccaagga aatactggga atgcaaacat ctgagatgga tcggaagaga      300

gaagcgttcc tagaacatct gaagcagaag tacccccacc acgcctctgc aatcatgggt      360

caccaagaga ggctgagaga ccagacaagg agccccaaac tgtctcacag tcctcaacca      420

cccagtctgg gtgacccggt cgagcattta tcagagacgt ccgctgattc tttggaagcc      480

atgtctgagg gggatgctcc aacccctttt tccagaggca gccggactcg tgcgagcctt      540

cctgtggtga ggtcaaccaa ccagacgaaa gaaagatctc tgggggttct ctatctccag      600

tatggagatg aaaccaagca gctcaggatg ccgaatgaaa tcacaagtgc agacacaatc      660

cgtgctctct tcgtaagtgc ctttccacag cagctcacca tgaaaatgct ggaatcgccc      720

agtgtcgcca tttacatcaa agatgaaagc agaaatgtct attatgaatt aaatgatgta      780

aggaacattc aagacagatc actcctcaaa gtgtacaaca aggatcctgc acatgcgttt      840

aatcacacac caaaaactat gaatggagac atgaggatgc agagagaact tgtttatgca      900

agaggagatg gccctggggc ccctcgcccc ggatctactg ctcatccacc ccatgcgatt      960

ccaaattccc caccgtctac tccagtgccc cattccatgc ccccctcccc gtccagaatt     1020

ccttatgggg gcacccgctc catggttgtt cctggcaatg ccaccatccc cagggacaga     1080

atctccagcc tgccagtctc cagacccatc tctccaagcc caagcgccat tttagaaaga     1140

agagatgtca agcctgatga agacatgagt ggcaaaaaca ttgcaatgta cagaaatgag     1200

ggtttctatg ctgatcctta cctttatcac gagggacgga tgagcatagc ctcatcccat     1260

ggtggacacc cactggatgt ccccgaccac atcattgcat atcaccgcac cgccatccgg     1320

tcagcgagtg cttattgtaa cccctcaatg caagcggaaa tgcatatgga acaatcactg     1380

tacagacaga aatcaaggaa atatccggat agccatttgc ctacactggg ctccaaaaca     1440

ccccctgcct ctcctcacag agtcagtgac ctgaggatga tagacatgca cgctcactat     1500

aatgcccacg gcccccctca caccatgcag ccagaccggg cctctccgag ccgccaggcc     1560

tttaaaaagg agccaggcac cttggtgtat atagaaaagc cacggagcgc tgcaggatta     1620

tccagccttg tagacctcgg ccctcctcta atggagaagc aagtttttgc ctacagcacg     1680

gcgacaatac ccaaagacag agagaccaga gagaggatgc aagccatgga gaaacagatt     1740

gccagtttaa ctggccttgt tcagtctgcg ctttttaaag ggcccattac aagttatagc     1800

aaagatgcgt ctagcgagaa aatgatgaaa accacagcca acaggaacca cacagatagt     1860

gcaggaacgc cccatgtgtc tggtgggaag atgctcagtg ctctggagtc cacggtgcct     1920

cccagccagc ctccacctgt gggcacctca gccatccaca tgagcctgct tgagatgagg     1980

cggagcgtgg cggaactcag gctccagctc cagcagatgc ggcagctcca gctgcagaac     2040

caggagttgc tgagggcaat gatgaagaag gccgagctgg aaatcagtgg caaagtgatg     2100

gaaacaatga agagactgga ggatcccgtg cagcgacagc gcgtcctagt ggagcaagag     2160

agacaaaaat atcttcatga ggaagagaag atcgtcaaga agttgtgcga gttggaagac     2220

tttgttgaag acttgaagaa ggactccacg gcagccagcc gattggttac tctgaaagac     2280

gtggaagacg gggctttcct cctgcgtcaa gtgggagagg ctgtagctac cctgaaagga     2340

gaatttccaa ccttacaaaa caagatgcga gccatcctgc gcatagaagt ggaggccgtg     2400

cggtttctga aggaggagcc acacaagctg gacagtctcc tgaagcgtgt gcgcagcatg     2460

acagacgtcc tgaccatgct gcggagacat gtcactgatg ggctcctgaa aggcacggac     2520

gcagcccaag ccgcacagta catggctatg gaaaaggcca cagccgcaga agtcctgaag     2580

agtcaggagg aggcagccca cacctccggc cagcccttcc acagcacagg tgcccctggc     2640

gatgcgaagt cggaagtggt gcctttgtcc ggcatgatgg ttcgccacgc gcagagctcc     2700

cctgtggtca tccagccctc ccagcactcc gtggccctgc tgaaccctgc tcagaacttg     2760

cctcacgtgg ccagctcccc agccgtcccc caggaagcaa cctccactct gcagatgtcg     2820

caggctccgc agtccccaca gatacccatg aatgggtctg ccatgcagag cttgttcatt     2880

gaagaaatcc acagtgtgag tgccaagaac agggcagtgt ctatcgagaa agcagaaaag     2940

aaatgggagg aaaaaaggca aaatctggat cactataatg ggaaagagtt tgagaagctc     3000

ctagaagaag ctcaggccaa tatcatgaag tcaataccaa atctggagat gccgccagcc     3060

acaggcccac tgccaagggg agatgcccca gtggacaagg tggaactttc agaagattct     3120

ccaaattcgg aacaggactt ggaaaagctg gggggaaagt cgccccctcc tcctccgcca     3180

cctcctcgtc gaagctacct gccaggatcg ggactcacca ccacgaggtc aggcgatgtg     3240

gtctacaccg gcagaaagga gaacatcacc gctaaggcaa gcagtgaaga tgctggacca     3300

agcccacaga ccagagctac aaaatatcca gcagaggagc ctgcttcagc ctggacccca     3360

tccccaccgc ctgtcaccac ctcctcctca aaggatgagg aggaagaaga agaagaagga     3420

gacaaaataa tggcagaact ccaggcattc cagaagtgtt cctttatgga tgtaaattca     3480

aacagtcatg ctgagccatc ccgggctgac agtcacgtta aagacactag gtcgggcgcc     3540

acagtgccac ccaaggagaa gaagaatttg gaatttttcc atgaagatgt acggaaatct     3600

gatgttgaat atgaaaatgg cccccaaatg gaattccaaa aggttaccac aggggctgta     3660

agacctagtg accctcctaa gtgggaaaga ggaatggaga atagtatttc tgatgcatca     3720

agaacatcag aatataaaac tgagatcata atgaaggaaa attccatatc caatatgagt     3780

ttactcagag acagtagaaa ctattcccag gaaactgtgc ctaaggccag tttcggtttc     3840

tctggcatta gtccattaga agatgaaata aacaaagggt ctaaaatctc aggcctgcaa     3900

tactctatac ctgacaccga gaaccagacg ctgaattacg gaaagacaaa ggagatggaa     3960

aagcaaaata cggataagtg tcacgtttcc tctcacacta gactaacaga atcaagcgtg     4020

catgatttta aaacagaaga tcaagaggtt atcacgacag attttggcca agttgttcta     4080

agacccaagg aggcaaggca tgctaacgtg aaccctaatg aggatggaga atcaagttca     4140

agttctccca ctgaagaaaa tgcagccact gacaatattg ccttcatgat taccgaaacc     4200

actgtccagg ttctttccag tggggaggtg catgatattg ttagccaaaa gggagaagac     4260

atacagacgg ttaatatcga tgccagaaaa gagatgaccc cccgacaaga agggactgac     4320

aatgaggatc cagtcgtgtg cctggacaag aaaccagtga tcatcatttt cgatgagccc     4380

atggacatcc ggtctgccta taagagactt tcaactatct ttgaggaatg tgatgaggaa     4440

ttagagagaa tgatgatgga ggaaaagata gaggaggagg aagaggagga aaatggggat     4500

tctgtagtcc agaataataa cacttcccag atgtctcata agaaggtggc cccaggcaat     4560

cttagaaccg gacaacaggt ggaaacaaag tcacagccac actccctggc cacagagacc     4620

agaaacccag gaggacagga aatgaacaga acggagctga acaagttcag ccacgtggat     4680

tctccaaatt cggaatgcaa gggtgaggac gcgaccgatg accagtttga aagccccaag     4740

aaaaagttta aattcaaatt ccctaagaag caactcgccg ctctcactca agccattcgc     4800

accggaacta aaacagggaa gaagactttg caagtggtag tctatgaaga agaggaagag     4860

gatggcaccc tgaaacagca caaagaagcc aagcgcttcg aaatcgctag gtctcaacct     4920

gaagacaccc ctgaaaacac agtgaggagg caagagcagc ccagcatcga gagtacatct     4980

ccgatttcaa gaactgatga aattagaaaa aacacctaca gaacattgga tagcctggag     5040

cagaccatta aacagctcga aaatacaatc agtgaaatga gtcccaaagc cctagttgat     5100

acctcatgtt cttccaacag agattctgtt gcaagttcat cccacatagc ccaagaggcc     5160

tctccccgac ccttgctagt tccggatgaa ggtcccactg ccctagagcc ccctacgtcg     5220

ataccttcag cttcacgtaa gggctccagc ggggccccac agacgagcag gatgcctgtc     5280

cccatgagtg ccaagaacag acccggaacc ctggacaaac ccggcaagca gtccaaactg     5340

caggatcccc gccaatatcg tcaggctaat ggaagtgcta agaaatctgg tggggacttt     5400

aagcctactt ccccctcctt acctgcttct aagattccag ccctttctcc cagctctggg     5460

aaaagcagtt ctctgccctc ttctagtggt gacagctcta acctccctaa tccacctgct     5520

actaaaccat cgattgcttc taaccctctc agcccccaaa caggaccacc tgctcactct     5580

gcctccctca tcccttctgt ctctaatggc tctttgaagt ttcagagcct cactcataca     5640

ggtaaaggtc accatctttc attctcaccg cagagtcaaa atggccgagc accccctcct     5700

ttgtcatttt cctcctcccc tccttctcct gcctcctccg tctcactgaa tcaaggtgcc     5760

aagggcacca ggaccatcca tactcccagc ctcaccagct acaaggcaca gaatggaagt     5820

tcaagcaaag ccaccccatc cacagcaaaa gaaacctctt aaaggtcaaa tcctattagg     5880

cacaagtcgg agttacattt aaaaaaaatt aacagtctac aacaactgtt ttcacaagag     5940

aatgtaacat attgctgtat cgtttgaggc ttaatgctaa atatgtgcta aatactggat     6000

taatagattt cagtaaagct cgttcgtttt gtttggtttt ctttttacct agttgctata     6060

gtgtctacag tctatactca atacctataa aatgcagtaa gcatgtgtta cagaaagagg     6120

ttctggtggg agagaaaggt gcgtgtgaga caggagaatt gtcttaagca tataaaacat     6180

gtatgattcc agaattttag tatgttttgt ataaaactat ttttcattac ggagactaga     6240

agtgaacaga gaattacaca agtgtgacta tacaaattgt aaaacagata ctataatatt     6300

tccttttatt ttagtgttat ttagctttat tacagatttc tatttttgtc aaaacttcat     6360

ggttcctttc aagatctttt ttgccaaaac attttgatac tatagcattg tacatttgaa     6420

agtagtgttc tagactataa aaccaatgaa cttctacatg agccctacag acaggcatgt     6480

gtagaaggca atttatcaaa cctattgcac tgccatgaaa agtgtgtata ataatttgct     6540

agcccaagca agctagtttt ctttgcttgc ttcttttctt tcttttttcc ttcctttttt     6600

tttttttttt cttttttaac atgttgagat tctctagttg ttttctttgg cgtatctaac     6660

cccttctttt gttttctgag acctggtaac ccacgctctt gcattgtgga ttttaaaatg     6720

tatactctgt acggttctgt aaaccgaaaa acttttgtaa atatataaat atacatagac     6780

ataaaaatac tgtatgtgac agcacataga gtagttttcc cacaccaaag ttaattttta     6840

tgcatgcttt aaaagtatat atcgggaccg gcagaaatgg aagtatccat acatttttaa     6900

aaagcaacaa gtttgcacag ctagagtgtt tttgtaaata aatgtatttg tataacacag     6960

tcatgtaata tacagaacta taagcagaga ctttgcaaaa ctaaataaag ggctgcatgc     7020

ttattatttt ttgtaccttg tcactataac tacttcctag tcaaagaacg aaatgtaact     7080

gttaccgagt taaatgtttt tccgctttga gggatgtaac cacatccact cagaggacac     7140

tacttttctg aaagctctgg ggtgactaat gatgagttcc taataaatta attgcaagtg     7200

tggtgccttg gatgtggcct gttggctcgc tttcttctct gtggcttatc aaggtgtaga     7260

tgacagaaag caaacctgga tacagagttt ccaccctcag ttcctggagg ggctcttatt     7320

attttctctc tttttaaaaa acttccagta gaagtaaagt ggaaataaaa tgtctttatc     7380

a                                                                     7381


<210> 1983
<211> 6123
<212> DNA
<213> Homo sapiens

<400> 1983
ggagagggct gcgcgcttct cgccaagcaa gcgggaggcg cactggggcc gccgccgttc       60

ccgcgctcct ccctctcctc tgcacccact gtcacgctac ccgcccgcgg gggagcctcg      120

agagcctcca ggtgaattga aagtcgtttc cgggggagga cggagagggt gctgcagtcc      180

tggcatgccc tgaaactgca agtcgggcag aaacgacccg gcggaggagc agggcgcgca      240

gcgccctgcg cagcatcccc gggctgccag aagaggccac cactcggctg gcagccgcga      300

gcggcggccg aacctcggcc ccagactcgg gcccccggca cgctcgcccg ggagataccc      360

cttccccctc ttgcgcattt cgcagctgcg ctggtgtggg gcatgagagc gaggtggctc      420

caggtctccg cggagcagct gccagtggga gagcgaggag aggcgagggg gcggcagcct      480

cggcccgaaa cggagatcct ggggtcctaa atttgtggcc gattgcactg tgtcctggag      540

acggagtgga accacagccc agagcccctg ggaatcatcc ctgaaagact gcattacttc      600

tccatggagt cttcctcctc ctgcttattt tctttttgga acaaggcaaa ggcaatctgc      660

atgtaacatc accagaagat gcagaatgcc gcagaaccaa ggaacgcctt tctaatggaa      720

acagtcgtgg ttcagtttcc aagtcttccc gcaatatccc aaggagacac accctagggg      780

ggccccgaag ttccaaggaa atactgggaa tgcaaacatc tgagatggat cggaagagag      840

aagcgttcct agaacatctg aagcagaagt acccccacca cgcctctgca atcatgggtc      900

accaagagag gctgagagac cagacaagga gccccaaact gtctcacagt cctcaaccac      960

ccagtctggg tgacccggtc gagcatttat cagagacgtc cgctgattct ttggaagcca     1020

tgtctgaggg ggatgctcca accccttttt ccagaggcag ccggactcgt gcgagccttc     1080

ctgtggtgag gtcaaccaac cagacgaaag aaagatctct gggggttctc tatctccagt     1140

atggagatga aaccaagcag ctcaggatgc cgaatgaaat cacaagtgca gacacaatcc     1200

gtgctctctt cgtaagtgcc tttccacagc agctcaccat gaaaatgctg gaatcgccca     1260

gtgtcgccat ttacatcaaa gatgaaagca gaaatgtcta ttatgaatta aatgatgtaa     1320

ggaacattca agacagatca ctcctcaaag tgtacaacaa ggatcctgca catgcgttta     1380

atcacacacc aaaaactatg aatggagaca tgaggatgca gagagaactt gtttatgcaa     1440

gaggagatgg ccctggggcc cctcgccccg gatctactgc tcatccaccc catgcgattc     1500

caaattcccc accgtctact ccagtgcccc attccatgcc cccctccccg tccagaattc     1560

cttatggggg cacccgctcc atggttgttc ctggcaatgc caccatcccc agggacagaa     1620

tctccagcct gccagtctcc agacccatct ctccaagccc aagcgccatt ttagaaagaa     1680

gagatgtcaa gcctgatgaa gacatgagtg gcaaaaacat tgcaatgtac agaaatgagg     1740

gtttctatgc tgatccttac ctttatcacg agggacggat gagcatagcc tcatcccatg     1800

gtggacaccc actggatgtc cccgaccaca tcattgcata tcaccgcacc gccatccggt     1860

cagcgagtgc ttattgtaac ccctcaatgc aagcggaaat gcatatggaa caatcactgt     1920

acagacagaa atcaaggaaa tatccggata gccatttgcc tacactgggc tccaaaacac     1980

cccctgcctc tcctcacaga gtcagtgacc tgaggatgat agacatgcac gctcactata     2040

atgcccacgg cccccctcac accatgcagc cagaccgggc ctctccgagc cgccaggcct     2100

ttaaaaagga gccaggcacc ttggtgtata tagaaaagcc acggagcgct gcaggattat     2160

ccagccttgt agacctcggc cctcctctaa tggagaagca agtttttgcc tacagcacgg     2220

cgacaatacc caaagacaga gagaccagag agaggatgca agccatggag aaacagattg     2280

ccagtttaac tggccttgtt cagtctgcgc tttttaaagg gcccattaca agttatagca     2340

aagatgcgtc tagcgagaaa atgatgaaaa ccacagccaa caggaaccac acagatagtg     2400

caggaacgcc ccatgtgtct ggtgggaaga tgctcagtgc tctggagtcc acggtgcctc     2460

ccagccagcc tccacctgtg ggcacctcag ccatccacat gagcctgctt gagatgaggc     2520

ggagcgtggc ggaactcagg ctccagctcc agcagatgcg gcagctccag ctgcagaacc     2580

aggagttgct gagggcaatg atgaagaagg ccgagctgga aatcagtggc aaagtgatgg     2640

aaacaatgaa gagactggag gatcccgtgc agcgacagcg cgtcctagtg gagcaagaga     2700

gacaaaaata tcttcatgag gaagagaaga tcgtcaagaa gttgtgcgag ttggaagact     2760

ttgttgaaga cttgaagaag gactccacgg cagccagccg attggttact ctgaaagacg     2820

tggaagacgg ggctttcctc ctgcgtcaag tgggagaggc tgtagctacc ctgaaaggag     2880

aatttccaac cttacaaaac aagatgcgag ccatcctgcg catagaagtg gaggccgtgc     2940

ggtttctgaa ggaggagcca cacaagctgg acagtctcct gaagcgtgtg cgcagcatga     3000

cagacgtcct gaccatgctg cggagacatg tcactgatgg gctcctgaaa ggcacggacg     3060

cagcccaagc cgcacagtac atggctatgg aaaaggccac agccgcagaa gtcctgaaga     3120

gtcaggagga ggcagcccac acctccggcc agcccttcca cagcacaggt gcccctggcg     3180

atgcgaagtc ggaagtggtg cctttgtccg gcatgatggt tcgccacgcg cagagctccc     3240

ctgtggtcat ccagccctcc cagcactccg tggccctgct gaaccctgct cagaacttgc     3300

ctcacgtggc cagctcccca gccgtccccc aggaagcaac ctccactctg cagatgtcgc     3360

aggctccgca gtccccacag atacccatga atgggtctgc catgcagagc ttgttcattg     3420

aagaaatcca cagtgtgagt gccaagaaca gggcagtgtc tatcgagaaa gcagaaaaga     3480

aatgggagga aaaaaggcaa aatctggatc actataatgg gaaagagttt gagaagctcc     3540

tagaagaagc tcaggccaat atcatgaagt caataccaaa tctggagatg ccgccagcca     3600

caggcccact gccaagggga gatgccccag tggacaaggt ggaactttca gaagattctc     3660

caaattcgga acaggacttg gaaaagctgg ggggaaagtc gccccctcct cctccgccac     3720

ctcctcgtcg aagctacctg ccaggatcgg gactcaccac cacgaggtca ggcgatgtgg     3780

tctacaccgg cagaaaggag aacatcaccg ctaaggcaag cagtgaagat gctggaccaa     3840

gcccacagac cagagctaca aaatatccag cagaggagcc tgcttcagcc tggaccccat     3900

ccccaccgcc tgtcaccacc tcctcctcaa aggatgagga ggaagaagaa gaagaaggag     3960

acaaaataat ggcagaactc cagggctcca gcggggcccc acagacgagc aggatgcctg     4020

tccccatgag tgccaagaac agacccggaa ccctggacaa acccggcaag cagtccaaac     4080

tgcaggatcc ccgccaatat cgtcaggcta atggaagtgc taagaaatct ggtggggact     4140

ttaagcctac ttccccctcc ttacctgctt ctaagattcc agccctttct cccagctctg     4200

ggaaaagcag ttctctgccc tcttctagtg gtgacagctc taacctccct aatccacctg     4260

ctactaaacc atcgattgct tctaaccctc tcagccccca aacaggacca cctgctcact     4320

ctgcctccct catcccttct gtctctaatg gctctttgaa gtttcagagc ctcactcata     4380

caggtaaagg tcaccatctt tcattctcac cgcagagtca aaatggccga gcaccccctc     4440

ctttgtcatt ttcctcctcc cctccttctc ctgcctcctc cgtctcactg aatcaaggtg     4500

ccaagggcac caggaccatc catactccca gcctcaccag ctacaaggca cagaatggaa     4560

gttcaagcaa agccacccca tccacagcaa aagaaacctc ttaaaggtca aatcctatta     4620

ggcacaagtc ggagttacat ttaaaaaaaa ttaacagtct acaacaactg ttttcacaag     4680

agaatgtaac atattgctgt atcgtttgag gcttaatgct aaatatgtgc taaatactgg     4740

attaatagat ttcagtaaag ctcgttcgtt ttgtttggtt ttctttttac ctagttgcta     4800

tagtgtctac agtctatact caatacctat aaaatgcagt aagcatgtgt tacagaaaga     4860

ggttctggtg ggagagaaag gtgcgtgtga gacaggagaa ttgtcttaag catataaaac     4920

atgtatgatt ccagaatttt agtatgtttt gtataaaact atttttcatt acggagacta     4980

gaagtgaaca gagaattaca caagtgtgac tatacaaatt gtaaaacaga tactataata     5040

tttcctttta ttttagtgtt atttagcttt attacagatt tctatttttg tcaaaacttc     5100

atggttcctt tcaagatctt ttttgccaaa acattttgat actatagcat tgtacatttg     5160

aaagtagtgt tctagactat aaaaccaatg aacttctaca tgagccctac agacaggcat     5220

gtgtagaagg caatttatca aacctattgc actgccatga aaagtgtgta taataatttg     5280

ctagcccaag caagctagtt ttctttgctt gcttcttttc tttctttttt ccttcctttt     5340

tttttttttt ttctttttta acatgttgag attctctagt tgttttcttt ggcgtatcta     5400

accccttctt ttgttttctg agacctggta acccacgctc ttgcattgtg gattttaaaa     5460

tgtatactct gtacggttct gtaaaccgaa aaacttttgt aaatatataa atatacatag     5520

acataaaaat actgtatgtg acagcacata gagtagtttt cccacaccaa agttaatttt     5580

tatgcatgct ttaaaagtat atatcgggac cggcagaaat ggaagtatcc atacattttt     5640

aaaaagcaac aagtttgcac agctagagtg tttttgtaaa taaatgtatt tgtataacac     5700

agtcatgtaa tatacagaac tataagcaga gactttgcaa aactaaataa agggctgcat     5760

gcttattatt ttttgtacct tgtcactata actacttcct agtcaaagaa cgaaatgtaa     5820

ctgttaccga gttaaatgtt tttccgcttt gagggatgta accacatcca ctcagaggac     5880

actacttttc tgaaagctct ggggtgacta atgatgagtt cctaataaat taattgcaag     5940

tgtggtgcct tggatgtggc ctgttggctc gctttcttct ctgtggctta tcaaggtgta     6000

gatgacagaa agcaaacctg gatacagagt ttccaccctc agttcctgga ggggctctta     6060

ttattttctc tctttttaaa aaacttccag tagaagtaaa gtggaaataa aatgtcttta     6120

tca                                                                   6123


<210> 1984
<211> 531
<212> DNA
<213> Homo sapiens

<400> 1984
atgggctgct gtggctgttc tggaggctgt ggctctggct gtgggggctg tggctccggc       60

agtgggggct gtggctctgg ctgtgggggc tgtggctcca gctgctgtgt gcccatttgc      120

tgctgcaagc ctgtgtgctg ctgtgtgcca gcctgttcct gctccagctg tggctcctgt      180

gggggctcca aagggggctg tggctcttgt gggagctcca agggtgggtg tggttcttgt      240

ggctgctccc agtccaactg ctgtaagccc tgctgctcct cctcaggctg tgggtcattc      300

tgctgccagt ccagctgctc caaaccctgc tgctgccaat ccagctgctg ccagtccagc      360

tgctgcaagc cctgctgctg ccaatccagc tgctgccagt ctagctgctt caagccctgc      420

tgctgccagt ccagctgctg tgtccccgtg tgctgccagt ccagctgctg caagccctgc      480

tgctcccagt ccagctgctg tgtccctatt tgctgtcagt acaagatctg a               531


<210> 1985
<211> 513
<212> DNA
<213> Homo sapiens

<400> 1985
atgggctgct gtggctgctc cggaggctgt ggctccggct gtgggggttg tggctccggc       60

tgtgggggct gtggctccgg ctgtgggggc tatggctctg gctgtggggg ctgtggctcc      120

agctgctgtg tgcccgtctg ctgctgcaag cccgtgtgct gctgtgtgcc agcctgttcc      180

tgctccagct gtggctcctg tgggggctcc aagggggact gtggctgtgg ttcctgtggg      240

ggctccaagg ggggctgtgg ttcttgtggc tgctcccagt gcaattgctg taagccctgc      300

tgctgctcct caggctgtgg atcctgctgc cagtccagct gctgcaatcc ctgctgctgc      360

cagtccagct gctgtgtccc cgtgtgctgc cagtctagct gctgcaagcc ctgctgctgt      420

cagtccagct gctgtgtccc ctccagctgc tgcaggtcct gctgctccaa gtccagctgc      480

tgtgtcccta tttgctgtca gtacaagatc tga                                   513


<210> 1986
<211> 2618
<212> DNA
<213> Homo sapiens

<400> 1986
cgaatcaccg ctcctgagcc cggtgcgggg ctgccgctat cgcctggccg tgggtgccgg       60

agcggccggg ttgcgactca gcgttcttgg gtgggcgcgg gcggcgtctc cgcggcgggc      120

atcccccgag gccgccctcg ggccatgatc gactccgtga agctgcgccg cgacagcgcg      180

gcggacttct tctcccacta cgagtacctg tgcgcgctgc agaactcggt gccgctgccc      240

gccgtgcgcg cctgtctccg ggagggcgtg ctggatttca acgccgaccg cctccgcggg      300

gtggactggg cgcctctgct gagcaccctc aagatcaata aagacctgcc cttggtctcc      360

atcaagagct tcttccagcc ctggctgggg gacacaggtt ctgacatgaa taaattttgc      420

agaagtcgtg ttcctgcgat aagatacaaa gatgtgacct tccagttgtg taaagctctt      480

aaaggctgtt taagtatatc aagtgtgcta aagaacctgg agctaaatgg actaattctg      540

agagagaggg atttaactat tctagcaaag ggattgaata aatcggcttc tttggtgcac      600

ctgtctcttg caaattgtcc aattggagat ggaggtttag aaattatttg tcaaggtata      660

aagagctcta tcactcttaa gacagtcaac ttcacaggat gtaatctgac atggcaggga      720

gcagatcaca tggccaagat cttaaagtat cagaccatga gaaggcatga agaaacctgg      780

gctgagagtc ttcgctatag gagacctgat cttgactgta tggctggctt aagacgtatc      840

acactgaatt gcaacacact tattggtgac ctaggtgcat gtgcttttgc agactctctc      900

agtgaggatt tatggctgag agctcttgac ctgcaacagt gcggcctcac caatgaagga      960

gcaaaggctt tgctagaggc ccttgaaacc aatacaactc tggtcgttct ggatataaga     1020

aaaaatccac tcattgatca ttctatgatg aaagcagtta tcaaaaaagt cctccagaat     1080

ggaaggagtg ccaaatcaga gtaccagtgg ataacttctc catcagtgaa ggaaccatcc     1140

aaaactgcta aacagaaaag gagaactata attctaggaa gtggtcacaa aggaaaagct     1200

actattagaa ttgtaggatt ggctacaaag aaacctgtaa gtagtggcag aaaacactcc     1260

cttggtaaag aatattatgc gcccgcacct cttccacctg gtgtgtctgg tttcttgccg     1320

tggcgtactg cagaacgtgc aaaaagacac aggggtttcc cattaatcaa aacacgtgat     1380

atatgtaatc agttgcagca accaggtttt cctgtgactg tgacagtaga gagtccttca     1440

tcctctgaag ttgaagaggt tgatgattct tcagagagtg ttcatgaagt gcctgagaaa     1500

actagtatag aacaagaagc attacaggaa aaactggagg agtgcctaaa gcagttaaag     1560

gaagaaagag tgataaggct taaggttgat aaacgagtca gtgagctgga acatgaaaat     1620

gcccagttaa gaaatataaa tttctctttg tctgaagccc ttcatgcaca gtcattgaca     1680

aatatgatcc tggatgatga aggtgttttg ggcagcattg agaattcttt tcagaagttt     1740

catgctttct tggatctcct taaagatgct gggcttgggc agcttgccac aatggctggg     1800

atagatcagt cagattttca attactaggt catccccaga tgacttctac tgttagtaat     1860

ccacctaaag aagaaaagaa ggcgcttgaa gatgaaaaac cagaaccgaa gcagaatgcc     1920

ctagggcaaa tgcaaaatat ccaggtttct atttgtatgc agtcagctta caatgaagga     1980

acactaatga agtttcagaa aattacaggt gatgctagaa ttcctttgcc tctcgactcc     2040

tttcctgtcc cagtttctac tccagagggc ttaggaactt ccagcaacaa cctaggagtc     2100

ccagctactg agcagcggca ggagtctttt gaaggattca ttgctagaat gtgttctcct     2160

tcaccagatg cgacttctgg aactggaagt caaagaaaag aagaggagtt gtccagaaat     2220

agcagatctt cttcagagaa aaagaccaaa acaggtgaat ataccaaaaa acactctgat     2280

aagcaacacc ctggaaagga cctgcattcc tgatctgact gtcctgaaaa ccagaaaagc     2340

aaagaaacta gggaaactag ttctttggtt aatgaaccaa ttaaaagtag gtctttgaaa     2400

aaatacgttt ctgtcaagaa agaaaataga atagtgactg tttcatccaa gacaaataaa     2460

agtaaatcca gtccactaga acattctgaa agtgatactc ttggatgtga ttttgaattt     2520

caagaaagca tccattctct atcacacctt tcatatgact aaatcttttg aaactatgtt     2580

tttaccttta aattttaata aattttctta tgttttta                             2618


<210> 1987
<211> 4574
<212> DNA
<213> Homo sapiens

<400> 1987
tgaaggtaaa attttccaga tacggcagac ggctttcaga gtacaataaa cagggaatga       60

gaactattta catggaagtt tctttctcat gatgcggtgg agaagcctcg gccacttggt      120

tctgccagat gttcctgggg ttactgtaaa tgggaaggac aggcagagct aaacaaggtt      180

tatcatttaa aagtgcctgt gtgaagtcac ttttgctgga aaactgcagc ttgggagctt      240

tctttgtatt cacatcccac tcttctgtca agtacacttt accctgacct tatgagtgga      300

tgaagatacc tcagttgtct gactttgcca attgcttaat ttcagaattt aaaaagggga      360

aagaaaaaca tcctgctaaa atatgaacat ctgagtgtct tattttccaa catcgtcaat      420

agctgtgagc gtcagcatta aatattctcc caaggagtgc catgatattg aagtcacttt      480

attaataaca gctgtatctg caaaacagtc aagagactcg gacgttgaaa gccagagatg      540

acactgagca tgcttttatt gcggcctacc atctttaagt gggacatatt gattgatgag      600

tgattgcctg tccatacact ctctcatcat cctgttcctt ggattggact tcactaagca      660

atttatcact caccttcaga cttacatgtg ggagttttca caacagtagt tttggaatca      720

ttagaacttg gattgatttc atcatttaac agaaacaaac agcccaaatt actttatcac      780

catggctttg aacgttgccc cagtcagaga tacaaaatgg ctgacattag aagtctgcag      840

acagtttcaa agaggaacat gctcacgctc tgatgaagaa tgcaaatttg ctcatccccc      900

caaaagttgt caggttgaaa atggaagagt aattgcctgc tttgattccc taaagggccg      960

ttgttcgaga gagaactgca agtatcttca ccctccgaca cacttaaaaa ctcaactaga     1020

aattaatgga aggaacaatt tgattcagca aaaaactgca gcagcaatgc ttgcccagca     1080

gatgcaattt atgtttccag gaacaccact tcatccagtg cccactttcc ctgtaggtcc     1140

cgcgataggg acaaatacgg ctattagctt tgctccttac ctagcacctg taacccctgg     1200

agttgggttg gtcccaacgg aaattctgcc caccacgcct gttattgttc ccggaagtcc     1260

accggtcact gtcccgggct caactgcaac tcagaaactt ctcaggactg acaaactgga     1320

ggtatgcagg gagttccagc gaggaaactg tgcccgggga gagaccgact gccgctttgc     1380

acaccccgca gacagcacca tgatcgacac aagtgacaac accgtaaccg tttgtatgga     1440

ttacataaag gggcgttgca tgagggagaa atgcaaatat tttcaccctc ctgcacactt     1500

gcaggccaaa atcaaagctg cgcagcacca agccaaccaa gctgcggtgg ccgcccaggc     1560

agccgcggcc gcggccacag tcatggcctt tccccctggt gctcttcatc ctttaccaaa     1620

gagacaagca cttgaaaaaa gcaatggtac cagcgcggtc tttaacccca gcgtcttgca     1680

ctaccagcag gctctcacca gcgcacagtt gcagcaacac gccgcgttca ttccaacagg     1740

gtcagttttg tgcatgacac ccgctaccag tattgataat tctgaaataa tcagcagaaa     1800

cggaatggaa tgccaagaat ctgcattgag aataactaaa cattgttact gtacatacta     1860

tcctgtttcc tcctcaatag aattgccaca aactgcatgc taaataaaga tgtagttctt     1920

ctggacagac cacaactcta agaagctagt gctgctatct catatatgag tattaaatat     1980

ggtatgctta gtatattcca acctaagata gttaactacc tgagaccagc tgtgatgttt     2040

aaagacataa aggataaagt ttacttttaa agggtttcta aacatagttt ctgtcctagg     2100

aatattgtct tatctccata actatagctg atgcagaaag tccagccagt ttactcattt     2160

cgattcagaa tatttcaaat ttagcaataa acaattagca ttagttaaaa aagaaacata     2220

ttccaagggc aggttcgatt ctagctctaa ttactgtcat gtcatttacc cactggatca     2280

aagggtatgt ttcacttctt gacaatataa atgctgcagc aaagatgaga ggtgaagtaa     2340

aaccgatacc tgtcctgcag gtctaaaatt tgaatggaaa ttcaagcaca agtactgggg     2400

acacatcaaa gtgtggtgtt tggtttgcct ggagatgcca cgttgaatca tgtgattcta     2460

gattaacatt aaatagattg aaaaagaaac tttgcacggt atgagcttca taccccacca     2520

aacaaagtct tgaaggtatt attttacaag tatattttta aagttgtttt ataagagaga     2580

ctttgtagaa gtgcctagat tttgccagac ttcatccagc ttgacaagat tgagaggccc     2640

atgccaacag tctaatctaa gagattagtc tttcaaactc accatccagt tgcctgttac     2700

agaataactc ttcttaacta aaaacctagt caaacaagga agctgtaggt gaggagatct     2760

gtataatatt ctaatttaag taagtttgag tttagtcact gcaaatttga ctgtgacttt     2820

aatctaaatt actatgtaaa caaaaagtag atagtttcac tttttaaaaa atccattact     2880

gttttgcatt tcaaaagttg gattaaaggg ttgtaactga ctacagcatg gaaaaaaata     2940

gttcttttaa ttctttcacc ttaaagcata ttttatgtct caaaagtata aaaaacttta     3000

atacaagtac atacatatta tatatacaca tacatatata tactatatat ggatgaaaca     3060

tattttaatg ttgtttactt ttttaaatac ttggttgatc ttcaaggtaa tagcgataca     3120

attaaatttt gttcagaaag tttgttttaa agtttatttt aagcactatc gtaccaaata     3180

tttcatattt cacattttat atgttgcaca tagcctatac agtacctaca tagtttttaa     3240

attattgttt aaaaaacaaa acagctgtta taaatgaata ttatgtgtaa ttgtttcaaa     3300

catccatttt ctttgtgaac atattagtga ttgaagtatt ttgacttttg agattgaatg     3360

taaaatattt taaatttggg atcatcgcct gttctgaaaa ctagatgcac caaccgtatc     3420

attatttgtt tgaggaaaaa aagaaatctg cattttaatt catgttggtc aaagtcgaat     3480

tactatctat ttatcttata tcgtagatct gataacccta tctaaaagaa agtcacacgc     3540

taaatgtatt cttacatagt gcttgtatcg ttgcatttgt tttaatttgt ggaaaagtat     3600

tgtatctaac ttgtattact ttggtagttt catctttatg tattattgat atttgtaatt     3660

ttctcaacta taacaatgta gttacgctac aacttgccta aaacattcaa acttgttttc     3720

ttttttctgt ttttttcttt gttaattcat ttaaactcat tgaaaacata gtatacatta     3780

ctaaaaggta aattatggga atcactgaaa tatttttgta gattaattgt tgtaacattg     3840

tctttctttt ttttcttttg tttcatgatt ttgattttta aaattattag cacacaacta     3900

ttttcagccc tttaataatg gagcatcaaa aacatcacct gtaaccccaa gcaaatatag     3960

aagactgtat tttttactat gatatccatt ttccagaatt gtgattacaa tatgcaaaga     4020

gtcataaata tgccatttac aataaggagg aggcaaggca aatgcataga tgtacaaata     4080

tatgtacaac agattttgct ttttatttat ttataatgta attttataga ataattctgg     4140

gatttgagag gatctaaaac tatttttctg tataaatatt atttgccaaa agtttgttta     4200

tattcagaag tctgactatg atgaataaat cttaaatgct ttgtttaatt aaaaaacaaa     4260

aatcaccaat atccaagaca tgaagatatc agttcaacaa atactgtagt taagagacta     4320

actctccact tgtatgggaa ctacatttca ctcttggttt tcaggatata acagcacttc     4380

accgaaatat tctttcagcc ataccactgg taacatttct actaaatctt tctgtaacac     4440

ttaaagaatt ccctcattca ttaccttaca gtgtaaacag gagtctaatt tgtatcaata     4500

ctatgttttg gttgtaatat tcagttcact cacccaatgt acaaccaatg aaataaaaga     4560

agcatttaaa agga                                                       4574


<210> 1988
<211> 1864
<212> DNA
<213> Homo sapiens

<400> 1988
ctgaaggtaa aattttccag atacggcaga cggctttcag agtacaataa acagggaatg       60

agaactattt acatggaagt ttctttctca tgatgcggtg gagaagcctc ggccacttgg      120

ttctgccaga tgttcctggg gttactgtaa atgggaagga caggcagagc taaacaaggt      180

ttatcattta aaagtgcctg tgtgaagtca cttttgctgg aaaactgcag cttgggagct      240

ttctttgtat tcacatccca ctcttctgtc aagtacactt taccctgacc ttatgagtgg      300

atgaagatac ctcagttgtc tgactttgcc aattgcttaa tttcagaatt taaaaagggg      360

aaagaaaaac atcctgctaa aatatgaaca tctgagtgtc ttattttcca acatcgtcaa      420

tagctgtgag cgtcagcatt aaatattctc ccaaggagtg ccatgatatt gaagtcactt      480

tattaataac agctgtatct gcaaaacagt caagagactc ggacgttgaa agccagagat      540

gacactgagc atgcttttat tgcggcctac catctttaag tgggacatat tgattgatga      600

gtgattgcct gtccatacac tctctcatca tcctgttcct tggattggac ttcactaagc      660

aatttatcac tcaccttcag acttacatgt gggagttttc acaacagtag ttttggaatc      720

attagaactt ggattgattt catcatttaa cagaaacaaa cagcccaaat tactttatca      780

ccatggcttt gaacgttgcc ccagtcagag atacaaaatg gctgacatta gaagtctgca      840

gacagtttca aagaggaaca tgctcacgct ctgatgaaga atgcaaattt gctcatcccc      900

ccaaaagttg tcaggttgaa aatggaagag taattgcctg ctttgattcc ctaaagggcc      960

gttgttcgag agagaactgc aagtatcttc accctccgac acacttaaaa actcaactag     1020

aaattaatgg aaggaacaat ttgattcagc aaaaaactgc agcagcaatg cttgcccagc     1080

agatgcaatt tatgtttcca ggaacaccac ttcatccagt gcccactttc cctgtaggtc     1140

ccgcgatagg gacaaatacg gctattagct ttgctcctta cctagcacct gtaacccctg     1200

gagttgggtt ggtcccaacg gaaattctgc ccaccacgcc tgttattgtt cccggaagtc     1260

caccggtcac tgtcccgggc tcaactgcaa ctcagaaact tctcaggact gacaaactgg     1320

aggtatgcag ggagttccag cgaggaaact gtgcccgggg agagaccgac tgccgctttg     1380

cacaccccgc agacagcacc atgatcgaca caagtgacaa caccgtaacc gtttgtatgg     1440

attacataaa ggggcgttgc atgagggaga aatgcaaata ttttcaccct cctgcacact     1500

tgcaggccaa aatcaaagct gcgcagccgc ggccgcggcc acagtcatga ctcagtcgac     1560

tgccaaagca atgaagcgac ctctcgaagc aactgtagac ctggcctttc cccctggtgc     1620

tcttcatcct ttaccaaaga gacaagcact tgaaaaaagc aatggtacca gcgcggtctt     1680

taaccccagc gtcttgcact accagcaggc tctcaccagc gcacagttgc agcaacacgc     1740

cgcgttcatt ccaacagtac ccatgatgca cagcgctacg tccgccactg tctctgcagc     1800

aacaactcct gcaacaagtg tccccttcgc agcaacagcc acagccaatc agttagttta     1860

tagc                                                                  1864


<210> 1989
<211> 915
<212> DNA
<213> Homo sapiens

<400> 1989
atggcgaaga ttgagaaaaa cgctcccacg atggaaaaaa agccagaact gtttaacatc       60

atggaagtag atggagtccc tacgttgata ttatcaaaag aatggtggga aaaagtatgt      120

aatttccaag ccaagcctga tgatcttatt ctggcaactt acccaaagtc aggtacaaca      180

tggatgcatg aaattttaga catgattcta aatgatggtg atgtggagaa atgcaaaaga      240

gcccagactc tagatagaca cgctttcctt gaactgaaat ttccccataa agaaaaacca      300

gatttggagt tcgttcttga aatgtcctca ccacaactga taaaaacaca tctcccttca      360

catctgattc caccatctat ctggaaagaa aactgcaaga ttgtctatgt ggccagaaat      420

cccaaggatt gcctggtgtc ctactaccac tttcacagga tggcttcctt tatgcctgat      480

cctcagaact tagaggaatt ttatgagaaa ttcatgtccg gaaaagttgt tggcgggtcc      540

tggtttgacc atgtgaaagg atggtgggct gcaaaagaca tgcaccggat cctctacctc      600

ttctacgagg atattaaaaa aaatccaaaa catgagatcc acaaggtgtt ggaattcttg      660

gagaaaactt ggtcaggtga tgttataaac aagattgtcc accatacctc atttgatgta      720

atgaaggata atcccatggc caaccatact gcggtacctg ctcacatatt caatcactcc      780

atctcaaaat ttatgaggaa agggatgcct ggagactgga agaaccactt tactgtggct      840

ttgaatgaga actttgataa gcattatgaa aagaagatgg cagggtccac actgaacttc      900

tgcctggaga tctga                                                       915


<210> 1990
<211> 3007
<212> DNA
<213> Homo sapiens

<400> 1990
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccaacgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg tggatggcca gggtacctgg     1200

ggactcaggc tgctgccagt tctgctcacc accatccgtg cttggcacag aagtagctgc     1260

atagaaaggg cactggattt gaagtcagaa gacctgggtt cttgaaccag cctgtcaacc     1320

agttgtatga ctttaaacaa ggcatctcac ctcttttcat cttgttttct tccaataatg     1380

ttagagttca tgtaatcaca ttctctagaa ccatttagtt tgtgttaact atgaaccaag     1440

cagtgtggtg gccactggtg acttgaaaat atagagaaaa aaaaaacctg ctctatatct     1500

gaaagagctc ttgggaagac agagaaacat aaagaggaaa ttacagcaca gtgtggtggg     1560

tgttacggga agtccaaccc cagcattatg ggagttcagg ggaaggggca tagcccagcc     1620

tggaaggaga gggtgagtgg gggatggctt tctgaaaagg gtggtctaaa ggatgcctat     1680

ggtcaatagg gaaaagaggg gaagaagcat cttaagaaga ggaaacagca gagaactggc     1740

tggatgacct gtgactctgg agcactgggt tgtctccatt gtcattatgg gcagatgtgt     1800

gccatcccca gccgacgcca ctcactgcct ccttcctcct ggtgttgcca cttctgggtg     1860

agattaaggt gcagggcctg ggggcaggag gacataaggt atagccataa atcataaccc     1920

agggaccaca ctcaacccta gggaaattgt cttcctgatc agttgattac catctgaggt     1980

caagaaatga gatagtggga gcaaatgggt cacaaatagc tcagctgtgg gctcagaaac     2040

tgctaggtaa aagaattcca gaaggaggcc agggcataag ttggatgacc tatgaacttt     2100

agtctaaaga attgagacta ccgtaattga gactactgta gtgacatctg agaaatggga     2160

tggaagagtg accatgtttt attttcttgt tcttgtcact attgtatttt attttgcata     2220

atcatgccct tcactgacag tctccttaac atcatctgtt tactctgctc agtgtaaact     2280

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2340

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2400

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     2460

gagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     2520

aaaatacaga cacacacaag tgcctatata atgataaaac atatccaaag cacccaaacc     2580

tgtgattcca gaaaagtaga tcctattttt gtttattttt attggcttta gctgtgtctt     2640

ttgaaaggac tattatcctc taaaatgtat gtgtatgaag atcctggctt gcagctcggg     2700

agctttacac accttgtgtc actttatctt ggtaacgagc caagatcatg caaccagttc     2760

atccatgtct gacccaagag ctcttaactg ctatgctgca ctgcctcatt cagagataga     2820

tgcctgcatg ggtcctggcg attattttaa tgctggctac acccccacag gtgacttgga     2880

ttcagaaata caatttatat ttcttctttt taaattgttt tattttattt ttcttttaat     2940

agttatatgt cagtgagaac aatttatatg tcttacactg agaaataaaa ctgctcataa     3000

gtgaaaa                                                               3007


<210> 1991
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 1991
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaatctgc ctaatcacct ggttatcccc acagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccaacgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct ga                                              1522


<210> 1992
<211> 3738
<212> DNA
<213> Homo sapiens

<400> 1992
ggagccggga caccgaggga agaggccgga gggagatcgc ggaggggagg gggcgggagg       60

ggggtggggt atcctgagtc gtccgtggtc cggagtctgg aaggccctag agcggcgcca      120

gtcgacccgc ctcgccacaa cttgcccaga ccagacacgt ttcatcctgc gccctgcaag      180

aaggagccgg cctgcctctc tccgctttgc tgctcctcgg cctccgcggg cccggcccgc      240

gtcagcagcg accctggggt ctgggtcccc tgtgtcgccc ccgcccgcct gcagcgcccg      300

gcacccgccc aggagcgcgc agctggggtt ctagggacgt atacttgagc aagagagacc      360

acagctcttg ttcccgctga tcctgcagcc cagtggatgg agtccagaat ctacagacct      420

gccaggaaag aaaaaaaaat tcctgatgtc tggtccaagc aggaattccc cggtggattg      480

gggaatgtct ggcttttcct cagcttattg atctctgtgg taaccactgg aggcccccag      540

aagacccata gaaatgagag gcctgaggtc tacaagtcgc tgctagaaat attttagcct      600

ctccaaagcc cagaatgcag ccccgaccca agtttgtaag ggttctgggt gcacgctgac      660

cctgcgcggg cagacgcgcc ctttgctcca ggtccggacc tgggcgctgc tatagcaacg      720

tcctggacgc ccagacctta ggccgccgcc gccgcggaag cgaggaaccc ggccttctcc      780

cgctcctgag ggctgtggcg gcggcggccc gggaggcggc ccaggctggg taaagaccgc      840

ccggctcctc ctatgcaagc tgaggcagcg gattggtttt caagcatgcc cttccagaag      900

catgtctact acccgctcgc cagcggccca gaggggcccg acgtcgctgt ggccgccgcc      960

gccgcgggtg cggcctccat ggcctgtgcg ccccccagcg cggcttcggg gcccctgccc     1020

ttcttccagt tcaggccgcg gctggagagt gtggactggc ggcggctgag cgccatcgac     1080

gtggacaagg tggcgggggc tgtggacgtg ctgacgctgc aggagaacat catgaacatc     1140

accttctgca agctggaaga cgagaagtgc ccacactgcc agtcgggggt ggacccggtg     1200

ctgctgaagc tcatccgtct ggcgcagttc accatcgagt acttgctgca ctcacaagag     1260

ttcctcacct cgcagctgca caccctggag gagcggctgc gcctgagcca ctgcgacggc     1320

gagcagagca agaagctgct caccaagcag gcgggggaga tcaagacgct caaggaagag     1380

tgcaaacgcc ggaagaagat gatctccacc cagcagctga tgatcgaggc caaagccaac     1440

tattaccagt gccatttttg tgacaaggcc tttatgaacc aagcttttct acaaagtcac     1500

attcaacgcc gccacactga agaaaattct cattttgagt atcagaaaaa tgcacagatt     1560

gagaagctcc ggagtgagat cgtcgtattg aaggaagagc tgcagctcac caggtctgag     1620

ctagaggctg cacaccatgc cagtgcagtc agattctcca aggaatatga aatgcagaaa     1680

acaaaagagg aagacttttt gaagttattt gacaggtgga aagaagaaga aaaggagaaa     1740

ctagttgatg aaatggaaaa agtcaaggag atgtttatga aggaatttaa agaattaact     1800

tcgaagaatt cagcattaga atatcaactg tcagaaatcc agaagtccaa tatgcagatc     1860

aagtccaaca taggcacatt aaaagatgca cacgagttta aagaagaccg ttctccatat     1920

ccccaggatt tccataatgt catgcagctt cttgatagtc aggaaagcaa atggacagct     1980

cgagttcaag ctattcatca agaacacaag aaagagaagg gtcggctcct gtcacatata     2040

gagaaacttc gaacctcaat gatagatgat ctaaatgcaa gcaatgtttt ctataagaaa     2100

aggatagaag agctagggca gagactccag gagcagaatg agctgattat aactcagaga     2160

cagcagatta aagactttac ctgtaatcca ttaaacagta tcagtgaacc caaaggaaat     2220

cctttagcct ggcaggcttt tgaatctcag ccagctgctc cagctgtgcc tatgaatgcc     2280

ccagccctgc acactttgga aactaaatca agtctgccaa tggtgcatga acaggcattc     2340

tcgtcgcaca tactggaacc aatagaagaa ctttcagagg aagaaaaagg aagggaaaat     2400

gaacagaaat taaataacaa caaaatgcat ttaaggaaag ctttgaagag taactcctcc     2460

ctcactaagg gactaagaac aatggtggag cagaacttga tggagaaact ggaaaccttg     2520

gggattaatg cagatatacg tggcatttca agtgatcagt tgcatagagt actaaaaagt     2580

gtggaatcag aaagacataa gcaagaaaga gaaataccta actttcatca aattcgagaa     2640

ttccttgaac atcaagtcag ctgtaaaatt gaggagaaag cactactctc ttcagatcag     2700

tgcagtgttt ctcaaatgga taccctttca actggagaag tacccaaaat gatacaactt     2760

ccttccaaaa acagacaact gattagacaa aaagctgttt ctactgatag gacatctgtt     2820

ccaaaaatta agaaaaatgt catggaagat ccttttccca gaaagtcttc aactattacg     2880

acccctcctt ttagttcaga ggaggagcag gaggacgacg acctcatccg ggcatacgca     2940

tccccaggcc cacttcctgt gccgccacca caaaacaagg gcagcttcgg gaagaacaca     3000

gtgaaaagtg acgcggacgg gaccgaggga agcgaaatcg aggacactga tgattctccc     3060

aagcccgcag gagtcgccgt taaaacacct actgaaaaag ttgaaaagat gtttccacat     3120

cgcaaaaatg tgaacaaacc agtcggtgga actaatgtcc ctgagatgtt tatcaaaaaa     3180

gaagaattac aagaactaaa gtgtgcggat gtggaggatg aagactggga catatcatcc     3240

ctagaggaag agatatcttt gggaaaaaaa tctgggaaag aacagaagga acctccacct     3300

gcgaaaaatg aaccacattt tgctcatgtg ctaaatgcct ggggcgcatt taatcctaag     3360

gggccaaagg gagaaggact tcaagaaaat gaatcaagca cattaaaaag cagcttagta     3420

actgtgactg attggagcga cacttcagat gtctaattcc acatgtcaga agattattcc     3480

agaagccagc agtatttcag tatcacagtg tttcagtaat ttgcctccat gattctagtg     3540

cttctgcctt accgtgtttc ccacagcaac acagagactg attcaaagaa caatggtctc     3600

tttaatggca cccaatacag tattgaaaat cagatcatca acagtatttc gaagcatgta     3660

aaggtgttta agacttccgc tgctgcttaa aaataacatg tcattgaagt cataaaaagt     3720

tttttcttca gaaaggta                                                   3738


<210> 1993
<211> 894
<212> DNA
<213> Homo sapiens

<400> 1993
cggttcctac caaccgttct tattgctggc ggcctgagga gcccatcatg gcgacgcccc       60

ctaagcggcg ggcggtggag gccacggggg agaaagtgct gcgctacgag accttcatca      120

gtgacgtgct gcagcgggac ttgcgaaagg tgctggacca tcgagacaag gtatatgagc      180

agctggccaa ataccttcaa ctgagaaatg tcattgagcg actccaggta aagactatgg      240

gattgggtac catttttttg gtatgtgtgg gcaagggagg gaaatgggaa gagagactcc      300

agacccaacc ctgtcacctg acctaagagt tcaccactga cccctacctc tttttccctg      360

gccccacagg aagctaagca ctcggagtta tatatgcagg tggatttggg ctgtaacttc      420

ttcgttgaca cagtggtgtg agtgtctacc cgcccctctg agcccacagg gttcagctta      480

ccccttccct catgcaactt atattttttt gagtatcttc tatgtaccag gcactatgcg      540

aggttttata tcccagtagg atataagcta ggtgctgggg atgtgacagt gaataaaata      600

ggacaaaatc cctgccttcc cagagcctca atttggggaa gggtggggag caaaacataa      660

actatgctaa acagtgataa ggacttctcc ccacttcctc taacctctct ttcctcagcc      720

cagatacttc acgcatctat gtggccctgg gatatggttt tttcctggag ttgacactgg      780

cagaagctct caagttcatt gatcgtaaga gctctctcct cacagagtaa gtccattcca      840

tgaggatagt gtgtaaaaac accaccattt ccaacactct tctcccttta ccca            894


<210> 1994
<211> 2548
<212> DNA
<213> Homo sapiens

<400> 1994
aggtgtcacc acagtgatgg cagtggagga cagcacgctg caagtagtgg tacgggtgcg       60

gccccccacc cctcgggagc tggacagtca gcggcggcca gtggttcagg tggtggacga      120

gcgggtgctg gtgtttaacc ctgaggagcc cgatggaggg ttccctggcc tgaaatgggg      180

tggcacccat gatggcccca agaagaaggg caaagacctg acgtttgtct ttgaccgggt      240

ctttggcgag gcggccaccc aacaggacgt gttccagcac accacgcaca gcgtcctgga      300

cagcttcctc cagggctaca actgctcagt gtttgcctac ggggccaccg gggctgggaa      360

gacacacacc atgctgggaa gggaggggga ccccggcatc atgtacctga ccaccgtgga      420

actgtacagg cgcctggagg cccgccagca ggagaagcac ttcgaggtgc tcatcagcta      480

ccaggaggtg tataatgaac agatccatga cctcctggag cccaaggggc cccttgccat      540

ccgcgaggac cccgacaagg gggtggtggt gcaaggactt tctttccacc agccagcctc      600

agccgagcag ctgctggaga tactgaccag ggggaaccgt aaccgcacgc agcaccccac      660

tgatgccaac gcgacttcct cccgctccca tgccatcttc cagatctttg tgaagcagca      720

ggaccgggtt ccaggactga cccaggctgt ccaggtggcc aagatgagcc tgattgacct      780

ggctggctca gagcgggcat ccagcaccca tgcgaagggg gagcggctgc gggagggggc      840

caacatcaac cgctctctgc tggcgctcat caacgtcctc aatgccttgg ccgatgcaaa      900

gggccgcaag acccatgtgc cctaccggga cagcaaactg acccgcctgc tcaaagactc      960

cctcgggggc aactgccgca cagtgatgat cgctgccatc agcccctcca gcctgaccta     1020

cgaggacacg tacaacaccc tcaaatatgc cgaccgggcc aaggagatca ggctctcgct     1080

gaagagcaat gtgaccagcc tggactgtca catcagccag tatgctacca tctgccaaca     1140

gctccaggct gaggtagccg ctctgaggaa gaagctccaa gtgtatgagg ggggaggcca     1200

gcccccacca caggacctcc caggatctcc caagtcggga ccaccaccag aacaccttcc     1260

cagctccccc ttgccacccc accctcccag ccagccctgc accccagagc tccctgcagg     1320

gcctagagcc cttcaagagg agagtctggg gatggaggcc caggtggaga gggccatgga     1380

agggaactct tcagaccagg agcagtcccc agaggatgag gatgaaggcc cagctgagga     1440

ggttccaacc cagatgccag agcagaaccc cacacatgca ctgccagagt cccctcgcct     1500

gaccctgcag cccaagccag tcgtgggcca cttctcagca cgggaactgg atggggaccg     1560

ttctaagcag ttggccctaa aggtgctgtg cgttgcccag cggcagtact ccctgctcca     1620

agcagccaac ctcctgacgc ccgacatgat cacagagttt gagaccctac agcagctggt     1680

gcaagaggaa aaaattgagc ctggggcaga ggccttgagg acttcaggcc tggccagggg     1740

ggcacctctg gctcaggagc tgtgttcaga gtcaatccct gtgccgtctc ctctctgccc     1800

agagcctcca ggatacactg gccctgtgac ccggactatg gcgaggcgac tgagtggccc     1860

cctgcacacc ctgggaatcc cgcctggacc caactgcacc ccagcccagg ggtcccgatg     1920

gcccatggag aagaagagga ggagaccaag cgccttggag gcagacagtc ccatggcccc     1980

aaagcggggc accaagcgcc agcgccagtc cttcctgccc tgcctaagga gagggtctct     2040

gcctgacacc caaccttcac aggggcccag cacccccaaa ggagaaaggg cctcctcccc     2100

ctgccattcc cctcgcgttt gcccagccac agtcatcaaa agccgggtgc ccctgggccc     2160

ttccgccatg cagaactgct ccaccccgct ggctctgccc actcgagacc tcaatgccac     2220

ctttgatctc tctgaggagc ctccctcaaa gcccagtttc catgaatgca ttggctggga     2280

caaaataccc caggagctga gcaggctgga ccagcccttc atccccaggg cacctgtgcc     2340

cctgttcacc atgaagggcc ccaagccaac atcttccctc cctgggacct ctgcctgcaa     2400

gaagaagcgc gttgcgagtt cctcagtctc ccatggccgc agccgcatcg cccgcctccc     2460

cagcagcact ttgaagaggc caggcccctt gtactcccag gtgactggca ctagggacag     2520

ggatagcctg ggccatggag gccgatga                                        2548


<210> 1995
<211> 978
<212> DNA
<213> Homo sapiens

<400> 1995
gagacggcgg cggctgtagc ggcgtgacag gagccccatg gcacctgccc agccccacct       60

cagcccatct tgacaaaatc taaggctcca tggagccacc acggggcccc cctgccaatg      120

gggccgagcc atcccgggca gtgggcaccg tcaaagtata cctgcccaac aagcaacgca      180

cggtggtgac tgtccgggat ggcatgagtg tctacgactc tctagacaag gccctgaagg      240

tgcggggtct aaatcaggac tgctgtgtgg tctaccgact catcaaggga cgaaagacgg      300

tcactgcctg ggacacagcc attgctcccc tggatggcga ggagctcatt gtcgaggtcc      360

ttgaagatgt cccgctgacc atgcacaatt ttgtacggaa gaccttcttc agcctggcgt      420

tctgtgactt ctgccttaag tttctgttcc atggcttccg ttgccaaacc tgtggctaca      480

agttccacca gcattgttcc tccaaggtcc ccacagtctg tgttgacatg agtaccaacc      540

gccaacagtt ctaccacagt gtccaggatt tgtccggagg ctccagacag catgaggctc      600

cctcgaaccg ccccctgaat gagttgctaa ccccccaggg tcccaggtag ggatgcctta      660

gctgaagagc tgctggggga gaaaaagatc ttggggctct tgtagaccac gagccatact      720

ttattcattt gtttacttga caaacattta ttgagcacct acaagtgtga gtaagggcat      780

gaaactggga ccttgggcaa gtcacctcat ttctctgggc ctcagttttc tcatctgtaa      840

agaggggatg atgatacttt ctaccatata aaggttctgg tgaggcttaa atgagttaag      900

acatgttcag tgcctagaac aggatctggt acagtgtaaa taatcaattt ttttgttatt      960

aattataaat atatttat                                                    978


<210> 1996
<211> 2458
<212> DNA
<213> Homo sapiens

<400> 1996
tgacccaata agggtggaag gctgagtccc gcagagccaa taacgagagt ccgagaggcg       60

acggaggcgg actctgtgag gaaacaagaa gagaggccca agatggagac ggcggcggct      120

gtagcggcgt gacaggagcc ccatggcacc tgcccagccc cacctcagcc catcttgaca      180

aaatctaagg ctccatggag ccaccacggg gcccccctgc caatggggcc gagccatccc      240

gggcagtggg caccgtcaaa gtatacctgc ccaacaagca acgcacggtg gtgactgtcc      300

gggatggcat gagtgtctac gactctctag acaaggccct gaaggtgcgg ggtctaaatc      360

aggactgctg tgtggtctac cgactcatca agggacgaaa gacggtcact gcctgggaca      420

cagccattgc tcccctggat ggcgaggagc tcattgtcga ggtccttgaa gatgtcccgc      480

tgaccatgca caattttgta cggaagacct tcttcagcct ggcgttctgt gacttctgcc      540

ttaagtttct gttccatggc ttccgttgcc aaacctgtgg ctacaagttc caccagcatt      600

gttcctccaa ggtccccaca gtctgtgttg acatgagtac caaccgccaa cagttctacc      660

acagtgtcca ggatttgtcc ggaggctcca gacagcatga ggctccctcg aaccgccccc      720

tgaatgagtt gctaaccccc cagggtccca gcccccgcac ccagcactgt gacccggagc      780

acttcccctt ccctgcccca gccaatgccc ccctacagcg catccgctcc acgtccactc      840

ccaacgtcca tatggtcagc accacggccc ccatggactc caacctcatc cagctcactg      900

gccagagttt cagcactgat gctgccggta gtagaggagg tagtgatgga accccccggg      960

ggagccccag cccagccagc gtgtcctcgg ggaggaagtc cccacattcc aagtcaccag     1020

cagagcagcg cgagcggaag tccttggccg atgacaagaa gaaagtgaag aacctggggt     1080

accgggactc aggctattac tgggaggtac cacccagtga ggtgcagctg ctgaagagga     1140

tcgggacggg ctcgtttggc accgtgtttc gagggcggtg gcatggcgat gtggccgtga     1200

aggtgctcaa ggtgtcccag cccacagctg agcaggccca ggctttcaag aatgagatgc     1260

aggtgctcag gaagacgcga catgtcaaca tcttgctgtt tatgggcttc atgacccggc     1320

cgggatttgc catcatcaca cagtggtgtg agggctccag cctctaccat cacctgcatg     1380

tggccgacac acgcttcgac atggtccagc tcatcgacgt ggcccggcag actgcccagg     1440

gcatggacta cctccatgcc aagaacatca tccaccgaga tctcaagtct aacaacatct     1500

tcctacatga ggggctcacg gtgaagatcg gtgactttgg cttggccaca gtgaagactc     1560

gatggagcgg ggcccagccc ttggagcagc cctcaggatc tgtgctgtgg atggcagctg     1620

aggtgatccg tatgcaggac ccgaacccct acagcttcca gtcagacgtc tatgcctacg     1680

gggttgtgct ctacgagctt atgactggct cactgcctta cagccacatt ggctgccgtg     1740

accagattat ctttatggtg ggccgtggct atctgtcccc ggacctcagc aaaatctcca     1800

gcaactgccc caaggccatg cggcgcctgc tgtctgactg cctcaagttc cagcgggagg     1860

agcggcccct cttcccccag atcctggcca caattgagct gctgcaacgg tcactcccca     1920

agattgagcg gagtgcctcg gaaccctcct tgcaccgcac ccaggccgat gagttgcctg     1980

cctgcctact cagcgcagcc cgccttgtgc cttaggcccc gcccaagcca ccagggagcc     2040

aatctcagcc ctccacgcca aggagccttg cccaccagcc aatcaatgtt cgtctctgcc     2100

ctgatgctgc ctcaggatcc cccattcccc accctgggag atgagggggt ccccatgtgc     2160

ttttccagtt cttctggaat tgggggaccc ccgccaaaga ctgagccccc tgtctcctcc     2220

atcatttggt ttcctcttgg ctttggggat acttctaaat tttgggagct cctccatctc     2280

caatggctgg gatttgtggc agggattcca ctcagaacct ctctggaatt tgtgcctgat     2340

gtgccttcca ctggattttg gggttcccag caccccatgt ggattttggg gggtcccttt     2400

tgtgtctccc ccgccattca aggactcctc tctttcttca ccaagaagca cagaattc       2458


<210> 1997
<211> 4725
<212> DNA
<213> Homo sapiens

<400> 1997
atggtctcta gcgaccggcc cgtgtcactg gaggacgagg tctcccatag tatgaaggag       60

atgattggag gctgttgcgt ttgctcagac gagagaggct gggccgagaa cccgctggtt      120

tattgcgacg ggcacggctg cagcgtcgcg gtgcatcaag cttgctatgg cattgttcaa      180

gtacccactg gaccgtggtt ttgcaggaaa tgtgaatctc aggagagagc agccagagtg      240

agatgtgaac tttgtcccca taaggatgga gctttaaaaa gaacagataa tgggggttgg      300

gcccatgtgg tttgtgccct gtatattcca gaggtacaat ttgccaatgt ttccacaatg      360

gaaccaattg ttttacagtc tgttccgcat gatcgttata ataagacttg ctacatttgt      420

gatgaacaag gaagagaaag caaagcagcc actggtgctt gcatgacatg taataaacat      480

ggatgtcgac aggctttcca tgtaacatgc gctcagtttg ccggactgct ttgtgaagaa      540

gaaggtaatg gtgccgataa tgtccaatac tgtggctact gtaaatacca ttttagtaag      600

ctgaaaaaga gcaaacgggg atctaatagg tcatatgatc aaagtttaag tgattcttcc      660

tctcactctc aggataaaca tcatgagaaa gagaaaaaaa aatataaaga gaaggacaaa      720

cacaaacaga aacacaagaa gcagccagaa ccatcacctg cattggttcc atccttgact      780

gttactacag aaaaaactta tacaagcact agcaacaact ctatatctgg atcattgaag      840

cgcttggaag atactactgc acgatttaca aatgcaaatt tccaggaagt ctctgcacac      900

acctctagtg gaaaagatgt ttcagagact agagggtcag agggcaaagg gaagaaatct      960

tcagctcaca gctcaggtca aaggggaaga aagcctggtg gtggaagaaa tccaggaaca     1020

actgtgtcag cagctagccc ttttcctcaa ggcagttttt caggaactcc aggcagtgta     1080

aagtcatctt ctggaagttc agtgcagtct ccccaggatt tcctgagctt tacagactca     1140

gatctgcgta atgacagtta ctctcactcc caacagtcat cagcaaccaa agatgtacat     1200

aaaggagagt ctggaagcca ggaagggggg gtaaatagtt ttagtacctt aattggcctc     1260

ccttcaacct cagctgttac ttcacagcct aaaagctttg aaaattcacc tggagatttg     1320

ggtaattcca gccttcctac agcaggatat aagcgggctc aaacttctgg catagaagaa     1380

gaaactgtaa aggaaaagaa aaggaaagga aataaacaaa gtaagcatgg gcctggcaga     1440

cccaaaggaa acaaaaatca agagaatgtt tctcatctct cagtttcttc tgcttcacca     1500

acatcatctg tagcatcagc tgcaggaagc ataacaagct ctagtctgca gaaatctcct     1560

acattgctca ggaatggaag tttacagagc ctcagtgttg gctcatctcc agttggttca     1620

gaaatttcca tgcagtatcg gcatgatgga gcttgcccaa caactacgtt ctcagagttg     1680

ctgaatgcaa tacacaacgg tatttataac agcaatgatg tagcagtatc gtttccaaat     1740

gtagtatctg gctcgggatc tagtactcct gtctccagct ctcacttacc tcagcagtct     1800

tctgggcatt tgcaacaagt aggagcgctc tctccctcag ctgtgtcatc tgcagcccct     1860

gctgttgcta caactcaggc aaatactcta tctggatctt ctctcagtca ggcaccatct     1920

catatgtatg gcaatagatc aaattcatca atggcagctc ttatagctca gtctgaaaac     1980

aatcaaacag atcaagatct tggagacaat agccgcaacc tagttggcag aggaagctca     2040

ccccgaggaa gtctctcgcc acgatcccct gtaagcagct tacagattcg ctatgatcaa     2100

ccaggcaaca gcagtttgga aaatctgcct ccagtagcag ccagcataga acagcttttg     2160

gagaggcagt ggagtgaagg acagcaattt ttactagaac agggtactcc tagtgacatt     2220

ttaggaatgc tgaagtcatt acaccaactt caagttgaaa accgaagatt agaggaacaa     2280

attaaaaact tgactgccaa aaaggaacgg cttcagttat tgaatgcaca gctttcagtg     2340

ccttttccaa caataacagc aaatcctagt ccgtctcatc aaatacacac attttcagca     2400

cagactgctc ctactactga ttccttgaac agcagtaaga gccctcatat aggaaacagc     2460

tttttacctg ataattctct tcctgtatta aatcaggact taacctccag tggacaaagt     2520

accagcagct catcagctct ttctacccca cctcctgctg ggcagagtcc ggctcaacaa     2580

ggctcaggag tgagtggagt tcagcaggtc aatggcgtga cagtgggggc actagctagt     2640

ggaatgcagc ctgtaacttc caccattcct gccgtgtctg cagtgggtgg aataattgga     2700

gctttgccag gtaaccaact ggcaattaat ggcattgtag gagctttaaa tggggttatg     2760

cagactcctg tcacaatgtc ccagaaccct acccctctca cccacacaac cgtaccacct     2820

aatgcaacac atccaatgcc agctacactg actaacagtg cctcaggact aggattactt     2880

tctgaccagc aacgacaaat acttattcat caacagcagt ttcagcagtt gttaaattct     2940

caacagctca caccagtaca caggcacccc cacttcacac agctaccacc aacccatttc     3000

tcaccatcca tggagataat gcaagtcaga aagtagcaag acttagtgat aaaactgggc     3060

ctgtagctca agagaaaagt tgacacctga gaaacatcta gaaattgcct atcctgctgt     3120

tctagcactt catctggctg cctttgcagt ccttttacta cagctatgaa gaaacgcaac     3180

aagaaactca atgcacaaca aaggattaat tgctgcaagg acattcttgt aaggctttga     3240

ttagttttct tgttgctttg ttgcactgaa atggaattcc catgccccta ccccttaccc     3300

cagttttttg aacatggaaa gaaaatttaa taacttttta aagtgacata atttacatgc     3360

aatatgttta tcaactcaag aatttaatat agttggtaca caactagttt tgtttataaa     3420

ttggagatgc aaatagcaaa actaaatact tgctccattt acaaactact tgattttatt     3480

gtacaagttg aaatatgctc ttttgtttgg gttacagtat gcttgctcta agtcaaattc     3540

caaggaacta atttcttctc ctggagttgc attgattcag tattacaaat atatagcaca     3600

tcacctggga cttggcaatc tttgttaaaa aaaaatttcc tttctaatgg gatttggcca     3660

attttggtaa tgaagttagg atggtaatgt ctgcatctgc taaaggtaat tttcttttga     3720

gaattgcttt ctttagtgtt aagacctact catattttga agaaatcttg agttaagtga     3780

gttctgaggc tgctggggga accagatcaa ttcaaagcta aatacttctt tcagaaaggg     3840

gccactgtgg aaagtgctgg tggggtttgc ccttgatcaa gtgcctccat tgtgctgcaa     3900

gggctgtaga cagcagggtg ggacagtcag tcctccgagc agcaggaatc atcccgtcac     3960

ctgcagcctt cccatgcttc cgcctttatt cagaactttc tgtgccactg tagatagctc     4020

aggcaaaact attacctggg tatttatcca ctaatgagtc acaagaaaag gagtggattt     4080

ggtaagaata gagatttgtt ttatttaaac cacttcccat tactgaccat taaaagctca     4140

ccactagagt tcctgaaaca ggtgaaacct gtatgacagc ccttccactt tggggagcca     4200

cgcttttgat gtgacagtac cgcagagtga ttcccccact gaggatgtca tcatcaaact     4260

cttctttggt gtgtgaatta ttagtggaaa agacccagct gtaattagac ctccactgtg     4320

tacttagctg gaagaacatg ttaattctgc aatatgtttc ttggttaaac attgcacagt     4380

tcttacctca tttctgtaaa taaagttttg tgaatctgtt ttgtattgtg acaaattcat     4440

aagataacat tgatattttg atttgtaata tttctaattg gtagatttaa ttgaaaagta     4500

aaattaattt atttttatat gttcagggga attttaaagt caaatctttt gtagataatt     4560

taaaaaatca gtgtggttta ttttacttat ttaacccact ggttgttatt ctgtaacagt     4620

ttgtataaat ggtaaatttt gaatgtgttg ttattttacc tagatgtaaa attccacatg     4680

tattaaaatg tacaaaatgt tttgttaata aaatttaata atgtt                     4725


<210> 1998
<211> 5126
<212> DNA
<213> Homo sapiens

<400> 1998
cgcgcacgca gggctagcct cgcccaggcc tcctccctca cgccggccgc aggacgggcg       60

cgcacgccaa gtgacgctcc gaggaggaag cgcagccccc ttcccctccc tcgctgcccc      120

tggcccagcg ggagcccccc ctccccccag tgcgcctgtg cggaggccct cttgattatg      180

tgtgccctct ccgggcgccc gcgttagcgg ccgggtggag gtggggaggg aagacgctga      240

ggaggaggag gaggcggagg aggcggtgga ggggaggtgg ggggaatcag caaggacatg      300

gctcctgact cctgtgcgga acgtgagtga ctgagcggca aagcccgaat ggtctctagc      360

gaccggcccg tgtcactgga ggacgaggtc tcccatagta tgaaggagat gattggaggc      420

tgttgcgttt gctcagacga gagaggctgg gccgagaacc cgctggttta ttgcgacggg      480

cacggctgca gcgtcgcggt gcatcaagct tgctatggca ttgttcaagt acccactgga      540

ccgtggtttt gcaggaaatg tgaatctcag gagagagcag ccagagtgag atgtgaactt      600

tgtccccata aggatggagc tttaaaaaga acagataatg ggggttgggc ccatgtggtt      660

tgtgccctgt atattccaga ggtacaattt gccaatgttt ccacaatgga accaattgtt      720

ttacagtctg ttccgcatga tcgttataat aagacttgct acatttgtga tgaacaagga      780

agagaaagca aagcagccac tggtgcttgc atgacatgta ataaacatgg atgtcgacag      840

gctttccatg taacatgcgc tcagtttgcc ggactgcttt gtgaagaaga aggtaatggt      900

gccgataatg tccaatactg tggctactgt aaataccatt ttagtaagct gaaaaagagc      960

aaacggggat ctaataggtc atatgatcaa agtttaagtg attcttcctc tcactctcag     1020

gataaacatc atgagaaaga gaaaaaaaaa tataaagaga aggacaaaca caaacagaaa     1080

cacaagaagc agccagaacc atcacctgca ttggttccat ccttgactgt tactacagaa     1140

aaaacttata caagcactag caacaactct atatctggat cattgaagcg cttggaagat     1200

actactgcac gatttacaaa tgcaaatttc caggaagtct ctgcacacac ctctagtgga     1260

aaagatgttt cagagactag agggtcagag ggcaaaggga agaaatcttc agctcacagc     1320

tcaggtcaaa ggggaagaaa gcctggtggt ggaagaaatc caggaacaac tgtgtcagca     1380

gctagccctt ttcctcaagg cagtttttca ggaactccag gcagtgtaaa gtcatcttct     1440

ggaagttcag tgcagtctcc ccaggatttc ctgagcttta cagactcaga tctgcgtaat     1500

gacagttact ctcactccca acagtcatca gcaaccaaag atgtacataa aggagagtct     1560

ggaagccagg aagggggggt aaatagtttt agtaccttaa ttggcctccc ttcaacctca     1620

gctgttactt cacagcctaa aagctttgaa aattcacctg gagatttggg taattccagc     1680

cttcctacag caggatataa gcgggctcaa acttctggca tagaagaaga aactgtaaag     1740

gaaaagaaaa ggaaaggaaa taaacaaagt aagcatgggc ctggcagacc caaaggaaac     1800

aaaaatcaag agaatgtttc tcatctctca gtttcttctg cttcaccaac atcatctgta     1860

gcatcagctg caggaagcat aacaagctct agtctgcaga aatctcctac attgctcagg     1920

aatggaagtt tacagagcct cagtgttggc tcatctccag ttggttcaga aatttccatg     1980

cagtatcggc atgatggagc ttgcccaaca actacgttct cagagttgct gaatgcaata     2040

cacaacgaca gaggtgacag ttctacacta acaaagcaag aacttaaatt cataggtatt     2100

tataacagca atgatgtagc agtatcgttt ccaaatgtag tatctggctc gggatctagt     2160

actcctgtct ccagctctca cttacctcag cagtcttctg ggcatttgca acaagtagga     2220

gcgctctctc cctcagctgt gtcatctgca gcccctgctg ttgctacaac tcaggcaaat     2280

actctatctg gatcttctct cagtcaggca ccatctcata tgtatggcaa tagatcaaat     2340

tcatcaatgg cagctcttat agctcagtct gaaaacaatc aaacagatca agatcttgga     2400

gacaatagcc gcaacctagt tggcagagga agctcacccc gaggaagtct ctcgccacga     2460

tcccctgtaa gcagcttaca gattcgctat gatcaaccag gcaacagcag tttggaaaat     2520

ctgcctccag tagcagccag catagaacag cttttggaga ggcagtggag tgaaggacag     2580

caatttttac tagaacaggg tactcctagt gacattttag gaatgctgaa gtcattacac     2640

caacttcaag ttgaaaaccg aagattagag gaacaaatta aaaacttgac tgccaaaaag     2700

gaacggcttc agttattgaa tgcacagctt tcagtgcctt ttccaacaat aacagcaaat     2760

cctagtccgt ctcatcaaat acacacattt tcagcacaga ctgctcctac tactgattcc     2820

ttgaacagca gtaagagccc tcatatagga aacagctttt tacctgataa ttctcttcct     2880

gtattaaatc aggacttaac ctccagtgga caaagtacca gcagctcatc agctctttct     2940

accccacctc ctgctgggca gagtccggct caacaaggct caggagtgag tggagttcag     3000

caggtcaatg gcgtgacagt gggggcacta gctagtggaa tgcagcctgt aacttccacc     3060

attcctgccg tgtctgcagt gggtggaata attggagctt tgccaggtaa ccaactggca     3120

attaatggca ttgtaggagc tttaaatggg gttatgcaga ctcctgtcac aatgtcccag     3180

aaccctaccc ctctcaccca cacaaccgta ccacctaatg caacacatcc aatgccagct     3240

acactgacta acagtgcctc aggactagga ttactttctg accagcaacg acaaatactt     3300

attcatcaac agcagtttca gcagttgtta aattctcaac agctcacacc agtacacagg     3360

cacccccact tcacacagct accaccaacc catttctcac catccatgga gataatgcaa     3420

gtcagaaagt agcaagactt agtgataaaa ctgggcctgt agctcaagag aaaagttgac     3480

acctgagaaa catctagaaa ttgcctatcc tgctgttcta gcacttcatc tggctgcctt     3540

tgcagtcctt ttactacagc tatgaagaaa cgcaacaaga aactcaatgc acaacaaagg     3600

attaattgct gcaaggacat tcttgtaagg ctttgattag ttttcttgtt gctttgttgc     3660

actgaaatgg aattcccatg cccctacccc ttaccccagt tttttgaaca tggaaagaaa     3720

atttaataac tttttaaagt gacataattt acatgcaata tgtttatcaa ctcaagaatt     3780

taatatagtt ggtacacaac tagttttgtt tataaattgg agatgcaaat agcaaaacta     3840

aatacttgct ccatttacaa actacttgat tttattgtac aagttgaaat atgctctttt     3900

gtttgggtta cagtatgctt gctctaagtc aaattccaag gaactaattt cttctcctgg     3960

agttgcattg attcagtatt acaaatatat agcacatcac ctgggacttg gcaatctttg     4020

ttaaaaaaaa atttcctttc taatgggatt tggccaattt tggtaatgaa gttaggatgg     4080

taatgtctgc atctgctaaa ggtaattttc ttttgagaat tgctttcttt agtgttaaga     4140

cctactcata ttttgaagaa atcttgagtt aagtgagttc tgaggctgct gggggaacca     4200

gatcaattca aagctaaata cttctttcag aaaggggcca ctgtggaaag tgctggtggg     4260

gtttgccctt gatcaagtgc ctccattgtg ctgcaagggc tgtagacagc agggtgggac     4320

agtcagtcct ccgagcagca ggaatcatcc cgtcacctgc agccttccca tgcttccgcc     4380

tttattcaga actttctgtg ccactgtaga tagctcaggc aaaactatta cctgggtatt     4440

tatccactaa tgagtcacaa gaaaaggagt ggatttggta agaatagaga tttgttttat     4500

ttaaaccact tcccattact gaccattaaa agctcaccac tagagttcct gaaacaggtg     4560

aaacctgtat gacagccctt ccactttggg gagccacgct tttgatgtga cagtaccgca     4620

gagtgattcc cccactgagg atgtcatcat caaactcttc tttggtgtgt gaattattag     4680

tggaaaagac ccagctgtaa ttagacctcc actgtgtact tagctggaag aacatgttaa     4740

ttctgcaata tgtttcttgg ttaaacattg cacagttctt acctcatttc tgtaaataaa     4800

gttttgtgaa tctgttttgt attgtgacaa attcataaga taacattgat attttgattt     4860

gtaatatttc taattggtag atttaattga aaagtaaaat taatttattt ttatatgttc     4920

aggggaattt taaagtcaaa tcttttgtag ataatttaaa aaatcagtgt ggtttatttt     4980

acttatttaa cccactggtt gttattctgt aacagtttgt ataaatggta aattttgaat     5040

gtgttgttat tttacctaga tgtaaaattc cacatgtatt aaaatgtaca aaatgttttg     5100

ttaataaaat ttaataatgt ttataa                                          5126


<210> 1999
<211> 1732
<212> DNA
<213> Homo sapiens

<400> 1999
gttgccgtag agatgggcag ggctggatgg agtggggtgc ggtgagctga gctgaccctg       60

cttcgccacg gggactgcag tgaccccggc ttgccggcag ggcgggtaac aggttgagcc      120

agggtggggc tgctcagggg cgtggagccg aggccaggat ttctctgaag acccggcaca      180

ggctattcct ttctgcgacg agcccattgc tatggaaacc aaagcgttag gccagcgggg      240

attgaggctg cgggatcatg acgggtctct ctcccgaaga accttgccta aggcttcccc      300

aagcggctac ttcctgagcg aacccgccca cccgcctgaa ggagagagtt ttccatggac      360

acagcctagc agaaagacgc agccttcgtg cttcgctgac tgctgaccac tgacccaccg      420

ccttgatgac agcaccctcg tgtgccttcc cagttcagtt ccggcagccc tcagtcagcg      480

gcctctcgca gataaccaaa agcctgtata tcagcaatgg tgtggccgcc aacaacaagc      540

tcatgctgtc tagcaaccag atcaccatgg tcatcaatgt ctcagtggag gtagtgaaca      600

ccttgtatga ggatatccag tacatgcagg tacctgtggc tgactcccct aactcacgtc      660

tctgtgactt ctttgaccct attgctgacc atatccacag cgtggagatg aagcagggcc      720

gtactttgct gcactgtgct gctggtgtga gccgctcagc tgccctgtgc ctcgcctacc      780

tcatgaagta ccacgccatg tccctgctgg acgcccacac gtggaccaag tcatgccggc      840

ccatcatccg acccaacagc ggcttttggg agcagctcat ccactatgag ttccaattgt      900

ttggcaagaa cactgtgcac atggtcagtt ccccagtggg aatgatccct gacatctatg      960

agaaggaagt ccgtttgatg attccactgt gagccatccc acgagcccct gcattggagt     1020

cagaggtaca gatctattgt tgatcttaca ccaagatcca aacttgaaca ttctactttt     1080

gttgatacag aaaaaaacag atgatgcctt ttatgagcac aaaaaagagt tgctgtagct     1140

tttaacttta taatccattt tttttaagat taaactaatt gtgagatggt gaagataaat     1200

tttctgccct gtgagtgaca ctggccaggg gataggttga ggcagatggt gcccagaaga     1260

aagagggcag cacccattgc acatggcagg cctggaatcc tgcagccctc cccaaaaaca     1320

gattgaccca ggaatgaatc tgctacaatt ccacctcatt ctttcacacc cagagccaga     1380

gccttaagca tcatggtacc tcttgcgctt cttacagtgg tggttcctgc tgccctccag     1440

gttgtgcatc tgaagcctac aagaaagttt gcctacctgg ggcagctgga tcacaaagtt     1500

ggctggaagt accagacagt gacagccacc ctggaggaga agaggaagga gaaggccaag     1560

atccactacc agaataagaa acagctcatg ggatggccgg gcgcggtggc tcacgcctgt     1620

aatcctagca ctttgggagg cggaggcggg cagatcagga ggtcaggaga ttgagaccat     1680

cctggctaac atggtgaaac ccagtctcta ctaaaaaaat aaaaaataaa aa             1732


<210> 2000
<211> 905
<212> DNA
<213> Homo sapiens

<400> 2000
tgattatgtg tgccctctcc gggcgcccgc gttagcggcc gggtggaggt ggggagggaa       60

gacgctgagg aggaggagga ggcggaggag gcggtggagg ggaggtgggg ggaatcagca      120

aggacatggc tcctgactcc tgtgcggaac gtgagtgact gagcggcaaa gcccgaatgg      180

tctctagcga ccggcccgtg tcactggagg acgaggtctc ccatagtatg aaggagatga      240

ttggaggctg ttgcgtttgc tcagacgaga gaggctgggc cgagaacccg ctggtttatt      300

gcgacgggca cggctgcagc gtcgcggtgc atcaagcttg ctatggcatt gttcaagtac      360

ccactggacc gtggttttgc aggaaatgtg aatctcagga gagagcagcc agagtggcag      420

agtctcgctc tgttgcccag gctaaagtgc agtggtgtga tctcagccca ctgcaacctc      480

tgctccccgg gttcaagcga ttctcctgcc tcagcctccc aaatggtatg caattcctgt      540

tggttagcct catctgaaaa cgtcactcct ggatacatag aacatcactg cgcatgtgca      600

tctccccacc cccgatgcct ggtgtctaac gttcctccag tttctggtgc tctgatgcat      660

tgcttttggg cttgtcttac tacagcagct ttcttcggtc ctcagtcatt taccacttgt      720

catatgtcct ttctagtttc cagggatatt cttttttata tttatggctt tatgccattt      780

atctcagttg tcatttggcg tttcaagaag gagaggtggt agtgtttaag tggaattaac      840

tacttgtgtt tctgatgtgg tcttttatat ttcttacagg gttttgtttt accaagtact      900

agtct                                                                  905


<210> 2001
<211> 1136
<212> DNA
<213> Homo sapiens

<400> 2001
cgcggcagcg cgcacgcagg gctagcctcg cccaggcctc ctccctcacg ccggccgcag       60

gacgggcgcg cacgccaagt gacgctccga ggaggaagcg cagccccctt cccctccctc      120

gctgcccctg gcccagcggg agccccccct ccccccagtg cgcctgtgcg gaggccctct      180

tgattatgtg tgccctctcc gggcgcccgc gttagcggcc gggtggaggt ggggagggaa      240

gacgctgagg aggaggagga ggcggaggag gcggtggagg ggaggtgggg ggaatcagca      300

aggacatggc tcctgactcc tgtgcggaac gtgagtgact gagcggcaaa gcccgaatgg      360

tctctagcga ccggcccgtg tcactggagg acgaggtctc ccatagtatg aaggagatga      420

ttggaggctg ttgcgtttgc tcagacgaga gaggctgggc cgagaacccg ctggtttatt      480

gcgacgggca cggctgcagc gtcgcggtgc atcaagcttg ctatggcatt gttcaagtac      540

ccactggacc gtggttttgc aggaaatgtg aatctcagga gagagcagcc agagtgatgg      600

tatgcaattc ctgttggtta gcctcatctg aaaacgtcac tcctggatac atagaacatc      660

actgcgcatg tgcatctccc cacccccgat gcctggtgtc taacgttcct ccagtttctg      720

gtgctctgat gcattgcttt tgggcttgtc ttactacagc agctttcttc ggtcctcagt      780

catttaccac ttgtcatatg tcctttctag tttccaggga tattcttttt tatatttatg      840

gctttatgcc atttatctca gttgtcattt ggcgtttcaa gaaggagagg tggtagtgtt      900

taagtggaat taactacttg tgtttctgat gtggtctttt atatttctta cagggttttg      960

ttttaccaag tactagtctt cagtctatcc tgtttacttg attttttccc actcaactca     1020

caaacatttt tgaatcatct catgaattct gctttccatt tacatttttg cccttttgtc     1080

ttttcctctt cgctgttaaa cttcctgaaa aaataaaact agttgattca cttctt         1136


<210> 2002
<211> 7196
<212> DNA
<213> Homo sapiens

<400> 2002
ggggactacg ggtcggcgtt gggctcagtg ggctcgaaac aaagggctgt ccggtgggga       60

ttcgtcgcgg cgccttctga gtggtcgggt cgaggcttct cggcctagca gtgccctcgc      120

tgcgcgatct caggcgggtt ctcctcggct ccgcgcagcc cgcgccgcgg tgggggaccc      180

ggcgcagcgg cacctgctgc cgagggaccc cgcggcccgc cccggtgctc gtgatggggc      240

tgatcttcgc caaactgtgg agcctcttct gtaaccaaga acacaaagta attatagtgg      300

gactggataa tgcagggaaa accaccattc tttaccaatt cttaatgaat gaagtggttc      360

atacttctcc aaccatagga agcaatgttg aagaaatagt tgtgaagaac actcattttc      420

ttatgtggga tattggtggt caggagtctc tgcgatcatc ctggaacaca tattactcaa      480

atacagagtt catcattctt gttgttgata gcattgacag ggaacgacta gctattacaa      540

aagaagaatt atacagaatg ttggctcatg aggatttacg gaaggctgca gtccttatct      600

ttgcaaataa acaggatatg aaagggtgta tgacagcagc tgaaatctcg aaatacctca      660

cccttagttc aattaaggat catccatggc acattcaatc ctgctgtgct ctcacaggag      720

aagggttatg ccaaggtcta gagtggatga cctcccggat tggtgtgaga taactttttt      780

gcttgaaaga gactgctcta tttattctgt gacatgaaca ttttttccta gtacctttgg      840

ctgctaaggc agcagcatgt ttaatttata acaacacaaa cctctgagag caacacttga      900

atcaagtgca gctgaactgg aacataaaag attttttctt aacttttttt ttttaacaca      960

ctaatcttca gttggatgaa tgtaatgtat aactatgttt tcagcaacaa ttcttctgtt     1020

tattctaatt aatcagtgac tgccttgtaa gaaatgtttg tcatatgcgt gatgtcttct     1080

gaaatattct tataacctta atgaccaatt gctttcaatt cttgaccagc actccctccc     1140

aaccagagaa ttactggttt gatagagtag tcttggaaac catcaggtac tgcctgcaga     1200

cttctccagc actaaatata tttgttccct ctataaacca ttcatctttc ggacagaact     1260

tactgtaaag aaagaaatct gcctagagga tatatgtaag gaagattcca catcatgagt     1320

acttgccttt taactttccc ccacattact gttgagtcat ggaataatgt ttaagttgtt     1380

atttgcatgg aaattaagta ggctgtttat ttatctaaag gaatcaagtc cactcttctg     1440

cctgcaacat ttgttcaaaa actaaccaag gtaaaatatt tatttgaaag cccaactttg     1500

atgttaaata ttcttgaata aatctgttat tttaagaata tcacattatt caatgcatat     1560

aaaactatca gaagttagta aatcatacca gcactaaaaa taagacaatt ggaatatatt     1620

ttagcatcag tttacaaaca actttattat caacagaaat tttagctctt ttctttgcaa     1680

gatatatcac agctgctttg ggcagtagct gaagccgaag tatgaacagt ccattttgtt     1740

tcttaaaatt tgaagtcgtg tctgtcatag catttttact accagcagta tgttacttaa     1800

aaaactacat ggctttcctt gaatttattt gacggtatta tgtaatagac ttgaaacaat     1860

tgccatcttt gtagttatgc cttgggttct aaaatgttat aggaaactgc tgaattgaat     1920

cctagctttt agaatattaa taggagactc aaagttaata ttcttaacaa cttaaaatta     1980

aaaaaagtca taatctatca aaagtttatt tattggatgg cattaaaaca tttttgaggc     2040

agttgtctaa tatgaacaat aatctaaaca atatattcct taaattaaga ggaaagacaa     2100

gtgtcgtatt tcgatcctgt ttattcaaat gtgtgatttt gctgaaatga aagggataaa     2160

atgaatactt agagaataat acttcatttt tgcagtactt tttaattttg ataaaaaaga     2220

tacaaagttc ataatatcaa aatatgtgtt caaaattggt attttaattt taatattttt     2280

gtaagttgat ttaaattttg ctcttttttc aggtgtgctt ggtttattat atttagtcaa     2340

gttaatttag tcgaatgtgg taacattttt ctgatttatc tttagttgga gcacaccctt     2400

gaactgaaca gtggccaaag gaaagctttc tgggctttgg aaagtagttg tttaactttg     2460

ttttaagccg ttttcttagt gattctgtat caagtagagg ataagtgtag tttaacttag     2520

tttttaatat aacccataat caagaacatg agcgaaaagc agacataaat cgatatggat     2580

ggtttgtggt gtgtgtggga tgtgggggaa ttaagaaaat gccatttacc taagcacagt     2640

ttgcctgaat ttctgcttgg ttgtgttgtt taccgtaagt actgagggta gtttccctaa     2700

gtctgtcctg agaaaaagca tacttagtac tcctgtattt gttcttatga aatgactatc     2760

tgccttcttg tatctagtaa gattggctgg ctcaattttc ttctgtcaaa ttatatggtt     2820

attttttata ttaccacatc agcattatat taaaagtgtt tttaatagtt gattgtattt     2880

tgccaactac tagtatagac tcaaatttgc tatttaattt ttaaaataca atttattttg     2940

taaatccttt aaaaaatatt tggttagttt tggattagaa atgatttatg ttagccatgt     3000

gttgaagatg aaattggcat cagtgtagac ggtgctgatt gggaaaagtt catgattagg     3060

aaattcatgt aagacttttt aagagtattt tttaggtttt cactcaatct ttcctgtcac     3120

agtaacgtga aaactgatta ttctttactc caagagaatg ttttaaccca agcaagtatc     3180

taatactaga gcattggttc tgacattcat tgtaaatcag tgaactgtaa gatactgtct     3240

aaaaaatgta catttgtaat tagtgccttt attcatattt tgaaataagt tcttagtttt     3300

atattatacc tgttctttag aagtcatgtt agcagctaat tatttcagtg atgaaataat     3360

ttgtgtttta tatccccctt cacctccatg tattggttag cacagtttat agtaagtgaa     3420

aagcaaggga cccacctaca ttaccttcag gagactgttc taccttttaa tttgaaaaca     3480

aggaaattaa attttaacag aaatctttta agtatgttat aaccaaagtg ttcaattatc     3540

cttgcaagtt caaatacagc atttttctta attttgagcg tgtcatgtcc ttcatcttta     3600

aacccatcat tcttattgaa gcccatttga gaactcttag aattaataga accttttata     3660

agggaatata tggaatattt tttattgtta atgtaactta attccttaaa acctggaata     3720

ttaatatata taatctatta aaagctgaag attaaatatg taatttttgc ttttagtttc     3780

ttgtgttagt atgcttaaag gtatcaatac ttttattcta tattcattag aagaaaggta     3840

ataaatttaa gtttcattgc tgaaaaattt taaatgagtg ccaccccata gccatagtca     3900

ttttgattaa gcataattta actttcatta tagcataaag agaaaataat tattttagta     3960

tggaaacagt gataggcagt gctgtaaaca atattctctg aaaagttgtg ggggtcacaa     4020

agaaaatttt aaagaatata gaagcttttt taaaaaatct ttttagtgta gtttcttaga     4080

acaaattata aacataatca ttctgaataa tcaattttta tttagtcctt aactatgtaa     4140

aaccgtatca gtagaaaaat gtgctggtgt cgtgtctaaa gatggataaa tttctttgga     4200

atttatcttt ggagaccaac tttatgaggc agactttttg tctacagctt tggaaccaaa     4260

aaaacttcac tctaattcag tcctaaaggc tattttacat tttgccgggg taaagtgact     4320

tcaagataca gcatggtgtc ttgtatctag tagaatattg tgctagccat ctaaaaaagt     4380

ggatttgagc cttaatttgg ccgtttctca attgtctagt tgaccttaga caattagtgt     4440

ccatggcttt ccttttgttt ttcccatact gaggaactta aactacagct ctaaaatgtc     4500

ttttggtttt aaaattctga atgcttatat actactatta aaaattaaaa atccctcaaa     4560

tagtagggca atacaggtaa tatgaaatta aatgtatttt tatccattat ttgattccca     4620

cctgttattt tatttagaat acgaatacaa ccaagtaggg aaaaacgtat cagtaactgc     4680

tattcaactt aaattcagcg aattaatagc tgaatagaaa tagctaatga caatgcaaaa     4740

gagaaaacaa gccatattgc taagaaaagg atagtaagct gcttagaaag aaccagcctg     4800

tgttggaaat aattctcttc tagataattt accttatttt cttggcttgt actaattgaa     4860

tggaagtggt taatttgttc agagtttatt gccgtttgat gccaccccag tctatagttc     4920

tgtgtgactt tccatattga aagagtaggg ttagtagcca ggttgtcagt cttttacaaa     4980

tgtctacata aatgtctaca taaatctgaa agtggtttat attcaaggtt agtttttcag     5040

tagcgtctcc tccttattca ttcactttta ctgtgaagac tgaaatccaa aagccaggtt     5100

ccccaaaaaa gtatttttaa aaaattttag gggaccaaaa taaatagagg aagaccaata     5160

taaaaaaata tgttcaacta ttccatttta aatttaaagc agaaaaaaaa attgtgcccc     5220

tcagacctaa aggcagcttt aaatgtatat agtttggtga aacatttggg aaatattaat     5280

ttggaggttt agaagcatac gaaaaacaaa ttcaaagcac ttgaaagtaa agacaatatc     5340

atgaggtcga aaaaacttca aaaggatatt aggtaagaga aaatgtgaat gaaagcagtg     5400

aatttctgcc tctcctcgta tttagggtac ttaaaattac taaaaaatac tgtcttttta     5460

ccatacagct agatggcctg tattattctt aatgtggcca aaggagtgaa gactgattag     5520

ggttttagaa tttggaactg tagtcacata aaggcatctt ttgcatttct taaaccagta     5580

atctacattt tctcctggaa atggagaaat atgaaatgtg ctgtgcatag cttttggaat     5640

agaaaacaaa gttttaaaag aatggatatg ttttcttgca caacttgtaa aattttaatt     5700

aaaaaattac ctcatttttc aatccataag gtgctttgct caagtttgtg ggatgtttgt     5760

accatcccat aaaaaccccc ttcacccaaa ctgtatttga aatatgcaaa attcataact     5820

aagggatagc attccttgga gactttgttt tgttttactc ttgtttacca gctgggccaa     5880

catggtagat atatgagatt cacatatggt ttcattaaag cacataggaa agtgctcagt     5940

caatatttaa ttagtttaat tagataaggg aaaggagaaa tcctaaattt gatggattct     6000

tttatactgt gaatatattt ccatcagtgt tggtaagata tcaaatgact atcagttgat     6060

cccagtcatc agtgacttat ttgcatattt aagccctatt cacaagagac cataatcatt     6120

ttaatcttat attttccctc aggaaattta gggactctga agcccctatt ttattctctt     6180

ggagtaaact gttgagtgta gttacaaaaa cttttattta tgacttaaaa aaagtttagc     6240

tgctatttca gtgaaagtgt aaaataaaac ggtcatgatt tttttcaatt acagaatagt     6300

tacaaatttt accatgttca tctattccac agagcatgtt aaaaacaaca acaacaaaaa     6360

cctaacagca attacaacct tggtgttgcg tttattctaa tcagagtgaa tgattataat     6420

cacactttgc tattttaaca taaattggtg ctttagagca ttaaagagga agcagcaggc     6480

cctgtactca gtatttatta tttcttgcct cagaatgcaa aacaacttta aagtgtctat     6540

attcatatat atgtgcattt cttaagattt aaatacaaac tgttgttact ccttaagctt     6600

caggctttct gcgaaagctc taagaatatc ttcattacta tgcttggtca actggaagat     6660

ggtattaata aggtcagaat taggaattgg attgctctgt gggtcctccg gtattgtgca     6720

gaggaaagaa aaatgtcttt cacaccacaa actgtgtgtc tgaaccccag ccaaacaaat     6780

gtgttccatt ggtccaatat ataagcatta acaacaacaa caaaaaattt aaaacaagta     6840

aattaatgca ttcacatgat cacttcttga aaatggttca aagcatgttt tcctgatggt     6900

gggattgttt aaatgacatg ttttaaagtt tttaatactt tattagttat gaagtgcttc     6960

ttttatatgt taagtttagg ttgccagtac tcataatttt tatttctgca attatgttat     7020

aatgagttgt ttgcatgcct acttaaccca agtaaaacga tgctgtttgc tctggaatgt     7080

tcatctttta gacaggtttt ggctcatttc caatcatggt gcaatatagt gtaacattca     7140

tttgttttca ttcaacagtt ttatttttgt cataataaat aattactttt ccaata         7196


<210> 2003
<211> 4673
<212> DNA
<213> Homo sapiens

<400> 2003
gcagtgcggc accttcccgt ctgatgctgg cgttgtgcgt atggtgccct gacgtctgtc       60

cacgtgggcg cggaagcaaa cagcgatgtc ccagacgcag gactacgagt gcaggagcca      120

taatgtcgac ctgccggagt cgaggattcc agggtcgaac actcggttgg agtgggtgga      180

gatcatcgaa ccgcgcaccc gcgagcgcat gtacgccaac ctggtcaccg gtgagtgcgt      240

gtgggacccg ccggccggcg tccgcatcaa gcgcaccagc gagaaccagt ggtgggagct      300

gttcgacccc aacacgtccc gcttctacta ctacaatgcc agcacgcagc gcacggtgtg      360

gcaccggccg cagggctgcg acatcatccc gctggccaag ctgcagacgc tgaagcagaa      420

cacggagtcc ccgcgcgcct cggcggagag cagccccggg cgcggcagca gcgtcagccg      480

tgagggcagc accagctcct ccctggagcc cgagcccgac actgagaaag cgcaggagtt      540

gccagcgagg gccgggcggc ccgcggcgtt tgggacagtg aaggaggaca gcggcagctc      600

ttcaccacca ggagtgttcc ttgagaagga ctatgagatt taccgggatt acagtgcgga      660

cggccagctt cttcactaca ggacctcctc gctgcggtgg aactcgggcg ccaaagagcg      720

catgctcatc aaggtcgctg atcgggagcc cagcttcctc gccgcccagg gcaatggcta      780

cgccccagac ggcccacctg gggtccgctc ccgcagaccc tccggcagcc agcactcacc      840

cagcctgcag accttcgccc cggaggctga cggcaccatc ttcttcccag agaggaggcc      900

gtcacccttc ctgaagaggg ccgagctccc agggagcagc tccccgctgc tggcccagcc      960

ccgaaagccc tccggggact cgcagccctc ctccccgcgc tatggctatg aacccccgct     1020

ctacgaggag cccccagtgg agtaccaggc ccccatctac gatgagcccc ccatggacgt     1080

gcaattcgag gctggcgggg gctaccaggc cggctctccc cagcggtcgc cgggccgtaa     1140

gccccggccg ttcctccagc ccaacaagca gggccccccc tcgccctgcc agcagctggt     1200

gctcaccaag cagaagtgtc ccgagcgctt cctgagcctg gagtacagtc ccgccggcaa     1260

ggagtacgtg cggcagctgg tctacgtgga gcaggcgggc tccagcccca agctgcgcgc     1320

cggcccgcgg cacaagtacg cgcccaaccc cggcggtggt tcgtactcct tgcagcccag     1380

cccctgcctg ctgagggacc agcgcctggg cgtcaagtcc ggagactaca gcaccatgga     1440

gggacctgag ctgcggcaca gccagccgcc cacgccgctg ccacaggccc aggaggatgc     1500

catgtcctgg tccagccagc aggacaccct gtcctccaca ggctactccc cgggcacgcg     1560

caagcggaag agcagaaagc cctctttgtg ccaagccacc agcgccaccc ccactgaggg     1620

ccccggggac ctgcttgtgg agcagcccct ggccgaggaa cagcccccgt gcgggaccag     1680

cctcgccccc gtgaagcgag cggaaggtga ggccgaaggg gcgcggggcg cggccgagcc     1740

cttcctggcg caggctcggc tggcctggga ggcgcagcag gcccacttcc acatgaagca     1800

gaggagcagc tgggactccc agcaggacgg ctctggctac gagagcgacg gcgccctgcc     1860

actgcccatg cccgggccgg tggtgcgggc cttcagcgag gacgaggcgc tggcccagca     1920

ggagaacagg cactggagga ggggcacctt cgagaagcta ggcttccccc agatcctgct     1980

ggagaagagc gtctccgtgc agaccaacct ggcctcacca gagccctacc tccacccctc     2040

acagtctgag gacctcgctg cctgtgccca gttcgagagc agccggcaga gccgcagcgg     2100

cgttcccagc tccagctgcg tcttccccac tttcacgctg cgcaagccct cctcggagac     2160

ggacatcgag aactgggcct ccaagcactt caacaagcac acgcagggcc tcttccggcg     2220

gaaggtgtcc atcgccaaca tgctggcctg gagcagcgag tccatcaaga agcccatgat     2280

cgtgacaagc gaccggcacg tgaagaagga ggcctgcgag ctcttcaagc tgatccagat     2340

gtacatgggt gaccggcggg ccaaggccga cccactgcac gtggccctgg aggtggccac     2400

caagggctgg agcgtgcagg gcctgcggga cgagctctac atccagctgt gccggcagac     2460

caccgagaac ttccgcctgg agagcctggc ccgcggctgg gagctcatgg ccatctgcct     2520

ggcctttttc ccgcccaccc ccaagttcca ctcctacctg gaaggctaca tctaccggca     2580

catggacccc gtcaatgaca ctaaagtgac acagcacata aaagagctcc tggaaagaaa     2640

cactaagaag aagtccaaat tgagaaagaa acccaagcct tatgttgaag agccggatgg     2700

ggtggcgata agcacgtatg ccaagtactg ttaccacaag ctacagaagg cagccctgac     2760

cggggccaag aaggggctga agaagcccaa cgtggaggag atccggcatg ccaagaacgc     2820

cgtgttcagc ccgtccatgt tcggcagcgc actgcaggag gtcatgggca tgcagagaga     2880

gcgctacccc gagcgccagc tgccctgggt gcagacacgg ctctctgagg aggtgctggc     2940

gctcaacggt gaccagacag agggcatctt cagggtccct ggggacattg acgaggtgaa     3000

tgccctgaag ctgcaggtgg accagtggaa ggtgcccaca ggcctggaag acccccacgt     3060

ccctgcgtcc ctgctgaagc tgtggtaccg ggagctggag gagcccctga tcccgcacga     3120

gttctacgag cagtgcatcg cgcactacga cagccccgag gcggcggtgg ccgtggtgca     3180

cgcgctgccc cgcatcaacc gcatggtgct gtgctacctc atccgcttcc tgcaggtctt     3240

cgtgcagccg gccaacgtcg cggtcaccaa gatggatgtc agcaacctgg ccatggtgat     3300

ggcgcccaac tgcttgcgct gccagtccga cgacccgcgc gtcatcttcg agaacacccg     3360

caaggagatg tccttcctgc gggtgctcat ccagcacctg gacaccagct tcatggaggg     3420

tgtgctgtag cgggggcgcc cggggacagg agggatgtcc tgccgccccc agccaggccg     3480

aactccgcac tcgctctccc ggcagagggg ccagaatcgc ccggcccagc cctggagccc     3540

cctccactcc cccaggcccc tggccccggc gctccccacg tcttctgcct ggtctgaggg     3600

tgcagccagg gcacagcagc ggcggggagg gcgcctctgg ccccccacct cacggccagt     3660

tcccgcgggc accgcctcgc cctccgctgg ccgcgggtca gctccgagaa agtgccttct     3720

gtgtcctgga gccgagcgac gctgcctcct tggggccggg ctgcctccct gtggctcctg     3780

cgcgccctgg cctgggcctt gcccagccgc cccggtctct ccttcccttt ctcctgtcct     3840

cgtcctggcc tgcagctctt cccagccccg agagagcttc ccgacctgtc cccgcctcct     3900

ctccctccct cggcccgtgg tccccagctg gtgactgctc aggagtttgg gggctccagg     3960

acagtgggcc cggggcctgg caggctctcg gtgggtgggg tgggggcccc caaaccaaag     4020

tcctctgggg tagggagcag ggctgggcag gcattctggg ggcagggtgg gggaggggcg     4080

agagtatttt tttcttcgtg taactgtaaa tccagaatct atcctgcatc gcagcccacc     4140

gtgtatagag atataaatag agggaaagat ataagaacta aatttgctaa tgacatagtt     4200

ttaacctaaa tgctatttat ctctgagccg tccccgtcct ccgtgcagag caagttgagg     4260

tcattccttc ttttcttctc cgatcttttt tcttggcttc tgaccaaaaa ccaagctcta     4320

ccccatcccc atcccagacc tgcaggagac gagcgagcgg gaaggcgccg ggcccgggac     4380

tgtccgttct cggggccaga gctgctgggg gaccgagttt gtacattttc cattttggaa     4440

ttttgagttc caattgttgt aaaacttaat ttctccccag tttttatata tatatttttt     4500

agagttccgt ttttatttat taaaaacaaa agccccagcc ctgccgaggc ctgggcggcg     4560

tcctcagtcg ggtggtcccg gggcctttgc ggtcccgccc ggctgagacg ctcgccccga     4620

cgcatggacc cgagaggcga cgacacgagt gaataaagtg cacatggacc ctg            4673


<210> 2004
<211> 1007
<212> DNA
<213> Homo sapiens

<400> 2004
tcctgctcac cggttgtttg tctttccgtc cattaggcaa tactgaacac tgcgcagctt       60

gcagaggtct cctggcagcc ctcattagga attctgtctg gccccgatca gaatactgga      120

gacgagacca cgagattgat gagtttgcct tgggagtcgg taagaaggtg aagccagggg      180

cgaacatggg tcagaaggtc actggaggga tcaagactgt ggacatgagg gaccccacgt      240

acaggcccct gaagcaggag ctccagggtc tggattactg caagcccacc cggctggatc      300

tgctactgga catgccccct gtgtcctatg atgtccagct gctgcattca tggaacaaca      360

acgaccgatc gctcaatgtc tttgtgaagg aggacgacaa gctcatcttt caccggcatc      420

cggtggccca gagcacggac gctatcaggg gcaaagtcgg gtatacccgt gggctgcacg      480

tgtggcagat cacgtgggcc atgagacagc ggggcacaca cgccgtggtg ggggtggcga      540

cggcagacgc ccccctgcac tctgtcgggt acacaaccct cgtggggaat aaccacgagt      600

cctggggctg ggacttgggg cgcaaccggc tctaccacga tggcaagaac cagccaagca      660

aaacataccc agcctttctg gaaccagatg agacattcat tgtccctgac tccttcctgg      720

tagccctgga catggacgac gggactctga gcttcattgt ggatggacag tacatgggag      780

tggcttttcg gggactcaag ggcaaaaaac tgtatcctgt agtgagtgcc gtctggggcc      840

actgtgagat ccgaatgcgc tacttgaacg gactcgatcc cgagccgctg ccgctcatgg      900

atttgtgccg tcgctcggtg cgcctggccc tggggaggga gcgcctgggg gagatccaca      960

cgctgccgct gccggcttcc ctcaaggcct acctcctcta ccagtga                   1007


<210> 2005
<211> 6279
<212> DNA
<213> Homo sapiens

<400> 2005
gccggagtcc tgaaagtcga gcgagctccg ggttttgaaa atgttggagg gaaaagctcc       60

tcggagatga gcgtgacccc ctggctcgtg gtggccgcct gttctcacta acgccatggc      120

ggggaccgga gtgagaaacc ggtgtctgtc actgactgca aagtgagcga gaagcaggct      180

gcgggccgtc ccagcacgac gtggagcccc gcggagacct cgagatgccc cgcggggaag      240

ctcctggccc cgggagacgg ggggctaagg acgaggccct gggcgaagaa tcgggggagc      300

ggtggagccc cgagttccat ctgcagagga aattggcgga cagcagccac agtgaacagc      360

aagatcgaaa cagagtttct gaagaactta tcatggttgt ccaagaaatg aaaaaatact      420

tcccctcgga gagacgcaat aaaccaagca ctctagatgc cctcaactat gctctccgct      480

gtgtccacag cgttcaagca aacagtgagt ttttccagat tctcagtcag aatggagcac      540

ctcaggcaga tgtgagcatg tacagtcttg aggagctggc cactatcgct tcagaacaca      600

cttccaaaaa cacagatacc tttgtggcag tattttcatt tctgtctgga aggttagtgc      660

acatttctga acaggctgct ttgatcctga atcgtaagaa agatgtcctg gcgtcttctc      720

actttgttga cctgcttgca cctcaagaca tgagggtatt ctacgcgcac actgccagag      780

ctcagcttcc tttctggaac aactggaccc aaagagcagc tgcacggtat gaatgtgctc      840

cggtgaaacc ttttttctgc aggatccgtg gaggtgaaga cagaaagcaa gagaagtgtc      900

actccccatt ccggatcatc ccctatctga ttcatgtaca tcaccctgcc cagccagaat      960

tggaatcgga accttgctgt ctcactgtgg ttgaaaagat tcactctggt tatgaagctc     1020

ctcggatccc agtgaataaa agaatcttca ccaccacaca caccccaggg tgtgtttttc     1080

ttgaagtaga tgaaaaagca gtgcctttgc tgggttacct acctcaggac ctgattggaa     1140

catcgatcct aagctacctg caccctgaag atcgttctct gatggttgcc atacaccaaa     1200

aagttttgaa gtatgcaggg catcctccct ttgaacattc tcccattcga ttttgtactc     1260

aaaacggaga ctacatcata ctggattcca gttggtccag ctttgtgaat ccctggagcc     1320

ggaagatttc tttcatcatt ggtcggcata aagttcgaac gagcccacta aatgaggatg     1380

tttttgctac caaaattaaa aagatgaacg ataatgacaa agacataaca gaattacaag     1440

aacaaattta caaacttctc ttacagccag ttcacgtgag cgtgtccagc ggctacggga     1500

gcctggggag cagcgggtcg caggagcagc ttgtcagcat cgcctcctcc agtgaggcca     1560

gtgggcaccg tgtggaggag acgaaggcgg agcagatgac cttgcagcag gtctatgcca     1620

gtgtgaacaa aattaaaaat ctgggtcagc agctctacat tgagtcaatg accaaatcat     1680

cattcaagcc agtgacgggg acacgcacag aaccgaatgg tggtggtgag tcagcgaatg     1740

gtggtggtga atgtaagacc tttacttcct tccaccaaac actgaaaaac aatagtgtgt     1800

acactgagcc ctgtgaggat ttgaggaacg atgagcacag cccatcctat caacagatca     1860

actgtatcga cagtgtcatc agatacctga agagctacaa cattccagct ttgaaaagaa     1920

agtgtatctc ctgtacaaat acaacttctt cctcctcaga agaagacaaa cagaaccaca     1980

aggcagatga tgtccaagcc ttacaagctg gtttgcaaat cccagccata cctaaatcag     2040

aaatgccaac aaatggacgg tccatagaca caggaggagg agctccacag atcctgtcca     2100

cggcgatgct gagcttgggg tcgggcataa gccaatgcgg ttacagcagc accattgtcc     2160

atgtcccacc cccagagaca gccagggatg ctaccctctt ctgtgagccc tggaccctga     2220

acatgcagcc agcccctttg acctcggaag aatttaaaca cgtggggctc acagcggctg     2280

ttctgtcagc gcacacccag aaggaagagc agaattatgt tgataaattc cgagaaaaga     2340

tcctgtcatc accctacagc tcctatcttc agcaagaaag caggagcaaa gctaaatatt     2400

catattttca aggagattct acttccaagc agacgcggtc ggccggctgc aggaaaggga     2460

agcacaagcg gaagaagctg ccggagccgc cagacagcag cagctcgaac accggctctg     2520

gtccccgcag gggagcgcat cagaacgcac agccctgctg cccctccgcg gcctcctctc     2580

cgcacacctc gagcccgacc ttcccacctg ccgccatggt gcccagccag gccccttacc     2640

tcgtcccagc ttttcccctc ccagccgcga cctcacccgg aagagaatac gcagcccccg     2700

gaactgcacc ggaaggcctg catgggctgc ccttgtccga gggcttgcag ccttacccag     2760

ctttcccttt tccttacttg gatactttta tgaccgtttt cctgcctgac ccccctgtct     2820

gtcctctgtt gtcgccatcg tttttgccat gtccattcct gggggcgaca gcctcttctg     2880

cgatatcacc ctcaatgtcg tcagcaatga gtccaactct ggacccaccc ccttcagtca     2940

ccagccaaag gagagaggag gaaaagtggg aggcacaaag cgaggggcac ccgttcatta     3000

cttcgagaag cagctcaccc ttgcagttaa acttacttca ggaagagatg cccagaccct     3060

ctgaatctcc agatcagatg agaaggaaca cgtgcccaca aactgagtat cagtgtgtta     3120

caggcaacaa tggcagtgag agcagtcctg ctactaccgg tgcactgtcc acggggtcac     3180

ctcccaggga gaatccatcc catcctactg ccagcgctct gtccacagga tcgcctccca     3240

tgaagaatcc atcccatcct actgccagcg ctctgtccac aggatcgcct cccatgaaga     3300

atccatccca tcctactgcc agcacactgt ccatgggatt gcctcccagc aggactccat     3360

cccatcctac tgccactgtt ctgtccacgg ggtcacctcc cagcgaatcc ccatccagaa     3420

ctggttcagc agcatcagga agcagcgaca gcagtatata ccttactagt agtgtttatt     3480

cttctaaaat ctcccaaaat gggcagcaat ctcaggacgt acagaaaaaa gaaacatttc     3540

ctaatgtcgc cgaagagccc atctggagaa tgatacggca gacacctgag cgcattctca     3600

tgacatacca ggtacctgag agggttaaag aagttgtact aaaagaagac ctggaaaagc     3660

tagaaagtat gaggcagcag cagccccagt tttctcatgg gcaaaaggag gagctggcta     3720

aggtgtataa ttggattcaa agccagactg tcactcaaga aatcgacatt caagcctgtg     3780

tcacttgtga aaatgaagat tcagctgatg gtgcggccac atcctgtggt caggttctgg     3840

tagaagacag ctgttgagtg actgtgagga tgaaccttca taccctttcc aagacgtgtt     3900

acacagacag acctttttaa gtcctggact tttaaatgac catgaagtta tcattgaatg     3960

ttaagatttt ttcttcttga ttttttaata cacgtaatct ttttgaagca gacattgtat     4020

acagaatctt acttctcttt gttcctgata tattaaaatg gccagttagg ctctttttgt     4080

agttgaattg tcttctaaag agattggatg gcctctaaag aggtatgtgt atctttattt     4140

cagatgtcac ccagagtaaa ttataattag aagtatagct agaatgagcc ccaaacctta     4200

gcctcattta ttttgttctg ttacataagt cattttcccc ttagagtgct tgaagaaatg     4260

ccacctacag gttgtgtact tttcataatg gtttccatga atgtagtacg ttcatacagg     4320

cttcattcaa cctggcgttc ccctccataa ttaagatgaa acattccggt tttctcacaa     4380

cacattagca catactgtcc attagcatat ctgggataac caggttttgg gggttgagtt     4440

ttggccttca tccttgtaga tccctttcct attgatttcc caccttccag tgaaattctg     4500

aaagtcttat cttaaaaatc gatccgctta ccatgggcct attcttgtaa gtttcagtta     4560

gcatttgcat gtgtaatatt aaaatgaaag agcttcttac ccagtgctgt tgcccttttg     4620

agtatttttg tttttaaaat aatgattgta aaatgtttta caagtaatgt aaaagctagt     4680

atcattctta catacttctg tgtttaaatt ttcattctta ccaaaacagt taactctttc     4740

tttccaatca atttatacaa aagaggtcgc tccagcccta ccacaggtct gactggcact     4800

gccttttgtt tgcccttgaa cagggcagtg ttgtggggac tgcaaaagag aaaacgtcca     4860

ggcgagccca gttgtcctcg cccacagggt cctgcaggct ccatcagtca ccgctttcta     4920

tggcgtttgt agttgtgtct tttaagaagt gagtgtgatt gtttacttga taaatcagct     4980

cactctctgg tgctttttag agaagtccct gattccttct taaacttgga atgatagatg     5040

aaattcacac ccctgcagat cagaaaaaac aaatagaaga aaatgagggt tacagtaacc     5100

tgttgtcttt atataacttg caacaaacta atttattttt ttttcctttt tttgtttttg     5160

gttttttatg gttttttaag gaaaatactt ttctcctttg aagttttaca gctttttgta     5220

aatgcgtcct gataatgatt aggaaaatcg accttttcat ccatgatgac catcctcata     5280

gctcagatct cctttcaaag tagtggcttt ctggatggta attccatctt aaggtgtcag     5340

aactattttc aaatgctgcc tttgacagtt cttggaattt tctgatatta agcagttcca     5400

tgcaaatatt cgtgttttat aaatagctct catagtctgc tccatcttga tagttaagtg     5460

atttctgaag cgtttgtgtg tgtgttgatc aggttgtgtg atatttttgc ttgatagaga     5520

atcaaatttg aaacaattaa ccagccagta gattgtctgt cagtgacctt ctgtagtaat     5580

aaagtttttg ccactgtaaa taaaaacagt atccgtagct atcaggatca ttgcgcactc     5640

atatatgcta agccttctgt tctctaatag aagcctttct tttccattgt ttctggatat     5700

ttgtattatc caaatgtgct tatttctttg ccttagcaca cgttttatgg agtacttgtt     5760

atactaggtt tgatttgaaa ctggtgcttg tcgcagaact gtcagagcat gaggagcgct     5820

cctcctgtgg gtggacgcat tcacgcactc ccaggttgca cctgctgctg gcggtgagca     5880

gggggttcag cagcttgacc gatgcccccc gagggggctc tccccagctt aaactttgtt     5940

gtttaaattt gttaactttt tatattaatg actattgaaa gtggtaataa aaatttatat     6000

tataggcttc aatgttttca tgaatgttac ccaaaaagct gtgttttctt tggtcagagg     6060

tcaaaattta tgaaaaacaa aatgctgtat gaatggaaat cattttgcaa ttgagtgaca     6120

cttcattgta attcacagtg taaatttaat ccaaactgaa attttgtttc aactgaattt     6180

gtaattaact ctgaatttgt ttttaatcat tagtaatatt tcagttgggt atctttttaa     6240

gtaaaaacaa caaataaact ctgtacatgt aaaacgtga                            6279


<210> 2006
<211> 1524
<212> DNA
<213> Homo sapiens

<400> 2006
gcgagggcgg ccccgggggc gagcggctgt gcgcggggcc aagggcgggg gcagcaggcc       60

ggagtcctga aagtcgagcg agctccgggt tttgaaaatg ttggagggaa aagctcctcg      120

gagatgagcg tgaccccctg gctcgtggtg gccgcctgtt ctcactaacg ccatggcggg      180

gaccggagtg agaaaccggt gtctgtcact gactgcaaag tgagcgagaa gcaggctgcg      240

ggccgtccca gcacgacgtg gagccccgcg gagacctcga gatgccccgc ggggaagctc      300

ctggccccgg gagacggggg gctaaggacg aggccctggg cgaagaatcg ggggagcggt      360

ggagccccga gttccatctg cagaggaaat tggcggacag cagccacagt gaacagcaag      420

atcgaaacag agtttctgaa gaacttatca tggttgtcca agaaatgaaa aaatacttcc      480

cctcggagag acgcaataaa ccaagcactc tagatgccct caactatgct ctccgctgtg      540

tccacagcgt tcaagcaaac agtgagtttt tccagattct cagtcagaat ggagcacctc      600

aggcagatgt gagcatgtac agtcttgagg agctggccac tatcgcttca gaacacactt      660

ccaaaaacac agataccttt gtggcagtat tttcatttct gtctggaagg ttagtgcaca      720

tttctgaaca ggctgctttg atcctgaatc gtaagaaaga tgtcctggcg tcttctcact      780

ttgttgacct gcttgcacct caagacatga gggtattcta cgcgcacact gccagagctc      840

agcttccttt ctggaacaac tggacccaaa gagctgcacg gtatgaatgt gctccggtga      900

aacctttttt ctgcaggatc cgtggaggtg aagacagaaa gcaagagaag tgtcactccc      960

cattccggat catcccctat ctgattcatg tacatcaccc tgcccagcca gaattggaat     1020

cggaaccttg ctgtctcact gtggttgaaa agattcactc tggttatgaa gctcctcgga     1080

tcccagtgaa taaaagaatc ttcaccacca cacacacccc agggtgtgtt tttcttgaag     1140

tagatgaaaa agcagtgcct ttgctgggtt acctacctca ggacctgatt ggaacatcga     1200

tcctaagcta cctgcaccct gaagatcgtt ctctgatggt tgccatacac caaaaagttt     1260

tgaagtatgc agggcatcct ccctttgaac attctcccat tcgattttgt actcaaaacg     1320

gagactacat catactggat tccagttggt ccagctttgt gaatccctgg agccggaaga     1380

tttctttcat cattggtcgg cataaagttc gaacgtaagc cagtcagttt tcatattttc     1440

taaaacatct cttgtatcaa ataatattcc ttagcttatt gactgccctc tgactcaatt     1500

gacacataaa ctaaataaag caca                                            1524


<210> 2007
<211> 4487
<212> DNA
<213> Homo sapiens

<400> 2007
gtctctccgc aggccccggc cgcggcgtcc tcgacaacct atcgaaggcg ccatggagcg       60

accggcgccc ctggccgtgc ttcccttctc ggaccccgcg cacgccctga gcctgctgcg      120

cggcctgagc cagctgcgcg ccgagcgcaa gttcctggac gtgaccctgg aggcggcggg      180

cgggcgcgac ttcccggcgc accgtgcggt gctggccgcc gccagcccct acttccgcgc      240

catgttcgcg gggcagctgc gcgagagccg cgccgagcgg gtgcgcctgc acggagtgcc      300

tcccgacatg ctgcagctgc tgctggactt cagctacacg ggccgcgtgg cggtaagcgg      360

cgacaacgct gagccgctgc tgcgcgccgc cgacctgctg cagttcccgg ccgtgaagga      420

ggcgtgcggg gccttcctgc agcagcagct cgacctggcc aactgcctgg acatgcagga      480

cttcgctgag gccttcagct gctcgggact ggcgagcgcg gcgcagcggt tcattctgcg      540

ccacgtgggc gagctgggcg ccgagcagct ggagcggctg ccactggcgc gcctgctgcg      600

ctacctgcgg gacgacgggc tgtgtgtgcc caaggaggag gccgcctacc agctggcgct      660

gcgctgggtc cgcgctgacc cgccgcgccg cgccgcgcac tggccgcagc tgctggaggc      720

cgtgcgcctg cccttcgtgc gccgcttcta cctgttggcg cacgtcgagg ccgagccgct      780

ggtggcgcgc tgcccaccct gcctgcgcct gctgcgcgag gcgcgcgact tccaggcggc      840

gcgctacgac cgccacgacc gcgggccctg tccccgaatg cgtcctcgcc cgtccaccgg      900

tctcgccgag atcctcgtgc tcgtgggcgg ctgcgaccag gactgtgacg agctggtcac      960

tgtcgactgc tacaacccgc agacgggtca gtggcgctac ctggccgagt tcccagacca     1020

cctgggcgga ggctacagca tcgtggcgct gggcaatgac atctacgtga cgggtgggtc     1080

cgatggctcc cggctctatg actgcgtgtg gaggtacaac tcaagcgtga atgagtgggc     1140

ggaggtggcg cccatgctga aggcccgcga gtaccacagc tcctctgtgc tggacggact     1200

gctgtacgtg gtggccgccg acagcaccga gcgctatgac cacaccactg actcctggga     1260

ggccctgcag cccatgacct accccatgga caactgctcc accactgcgt gccgtggccg     1320

gctctatgcc atcggctccc tggctggcaa ggagaccatg gtgatgcagt gctacgaccc     1380

ggacaccgac ctgtggtcgc tggtggactg cggccagctc ccgccctggt ccttcgcccc     1440

caagactgcg actctaaacg gactcatgta ctttgtcagg gatgactccg ctgaggtgga     1500

cgtgtacaac ccgacgagga acgaatggga caagatcccg tccatgaatc aggtacatgt     1560

ggggggcagc ctggccgtcc ttggggggaa gctgtacgtc tctgggggat acgacaatac     1620

atttgaactc tcggacgtgg tagaggccta tgacccagag actcgcgcgt ggagcgtggt     1680

ggggcggctc ccagaaccca ccttctggca tggcagtgtc agcatcttcc gccagttcat     1740

gccccagacc ttctcgggtg ggcgtggctt cgagttggac agtggcagcg atgacatgga     1800

cccaggccga ccccggccgc cgcgggaccc cgatgagctg cactagcccc agtctggccc     1860

ggcacgggcc tcggtgcagg taactggcac ctctgcgggg cagtgcccca ctcctttgtg     1920

cacaaggaca cgttgggctc acaggaggag cacaggctct tgggtggcga agccagccca     1980

ggatccatta cctggaaggt ttctgtacct tgagagcctg aatcagaggc cgtcgggaac     2040

gccctccctg cagttgagga agagccactt tcctgccagc acatgtttct gggtcttgga     2100

ggtcaccccc accccgcgga tcacagctca cccacgcggc gcacacccct cctgccgttg     2160

tcatctgcac ctacttgttc ccaccttggg agaggacgat gacttgggag ggacgcgtga     2220

agggagaagg ggtcctccca tgaggctgag gatggcctga acctggagca gcggaccagg     2280

cagacgggct gaagtggggt cccaaattcc atgtccagag gtgtggggag cctgcctccc     2340

tagctcctgg cccctgccag gggcttacat caaaacacct cagagggctg ccctccagag     2400

gctgcaccca gaacagtggg acatgagcag gggtgtgggc ttggagggtg aagaggatgt     2460

ggtcctatca gatgctgggc ctcctcagcc atagccccct gctcctaccc cctgactggc     2520

tcttgcgtcc tcacctctca ccctctcctt cccgggaggc cctgggaggt gatcattgac     2580

acccagccaa gcagacagct gcgggtgccc aagcccttgc tgggcctgcg cgtgaggagt     2640

cccactgctt ctaaaggaag tcctgggcag gaggtggctt tggtggttgg ttccaaagtt     2700

gaaaatgctt gcagtttgac cttagaagaa gtgggaagaa gaaggagctc tacagggtca     2760

gctttgtttg atttgtccag tctaagaagt cccattgcca aagctttctg caggagggtg     2820

aatgccgcag cttggcagcc cctgggtttc tcttggaaat ggtcagtttc ccctcaaagt     2880

acccaaagta gccttggctt gagtttttgt ccttgcctcc tttttagaga agagggcatt     2940

tagactgcat tttcctggtt aaagaaggtt aaagcaaatg tttattgcct tttctagtga     3000

actaactcgt agagatgttc tcagcaggaa gacagtctta gcactgtcac ttagcagatt     3060

gcacttaagt cccttgtgct ggccagatgg cgtggctggt tgccttaata tgtcccagga     3120

cccctgacag ggctgcctgg cctctccctc gtgctcctca agagcccagt ccatacactg     3180

tggatgtcat tgctgtcggg ttaggaagtc ttgtcctaga acgccctggc tggtatgacc     3240

acagttcatg gcggctcttc tcgcttgggt catggtcatc ttccagcacc tgctgtgctg     3300

ggaaggccga ggatgggggc ccagcactgt ccaggcctgc tggggcctgg ctgggagtcc     3360

tgtgggcagc atggaacatg cagctgggct tcctgtgacc aggcaccctc tggcactgtt     3420

gcttgccctg tgccctggac cttttcctgc ccttctcctt cctctgctcc cttggggcta     3480

ccccttggcc cctcctggtc tgtgcaaact ccctcaggga gcccccctgc cctgtagctc     3540

tcgcttaact tcctaggggc tgctgagccc acccagaggt tgttggagtt cagcggggca     3600

gcttgtctcc cttgtcagca ggggcgtaag ggctgggttt ggccatacaa ggttggctac     3660

gccctcaatc cctgaccgtt ccaggcactg agctgggcac ccacggaagg acatgctgtc     3720

cagactgtga tgactgccag cacagggcat ctcgggcttg gctggtctgc gaggccttgc     3780

ccctgtggaa ctctgggttc ctgttttctc agtctttttt gcggctttgc tgtggttggc     3840

agctgccgta ctccaggctt gtgtcggcca ctcagatgag ggctgtggtg cgagccagtg     3900

caggagagct gcgcttggga ttgtgccctc tcctgtgtct gtcctccgga cctacccagg     3960

tctccaccat caggaccctg tctttgggtt tagaagacca agtatgggga aaaccaggca     4020

ccagcctctg cagcaatggg tccctctagc ctgtggacac cagctggggg atccagggtc     4080

aggccccctc ctctccccag tttccctctg ctgtgggttc tgggctgtca tgtctccacc     4140

acttaaggat gtctttacac tgacttcagg atagatgctg ggatgcctgg gcatggccac     4200

atgttacatg tacagaactt tgtctacagc acaaattaag ttatataaac acagtgactg     4260

gtatttaatg ctgatctact ataaggtatt ctatatttat atgacttcag agacgcgtat     4320

gtaataaagg acgccctccc tccagtgtcc acatccagtt caccccagag ggtcgggcag     4380

gttgacatat ttatttttgt ctattctgta ggcttccatg tccagaatcc tgcttaaggt     4440

tttagggtac cttcagtact ttttgcaata aaagtatttc ctatcca                   4487


<210> 2008
<211> 6445
<212> DNA
<213> Homo sapiens

<400> 2008
cgcgctcgcg gggggcggtg gcgcccggca cagaggggtt aagggggcgg tgcagacgtc       60

tccccgccca tcccgcccct cgagagccgc ggcgccccgc cctatttata gcagcggtgc      120

ctagcgcgcc gcgtctctcc gcaggccccg gccgcggcgt cctcgacaac ctatcgaagg      180

cgccatggag cgaccggcgc ccctggccgt gcttcccttc tcggaccccg cgcacgccct      240

gagcctgctg cgcggcctga gccagctgcg cgccgagcgc aagttcctgg acgtgaccct      300

ggaggcggcg ggcgggcgcg acttcccggc gcaccgtgcg gtgctggccg ccgccagccc      360

ctacttccgc gccatgttcg cggggcagct gcgcgagagc cgcgccgagc gggtgcgcct      420

gcacggagtg cctcccgaca tgctgcagct gctgctggac ttcagctaca cgggccgcgt      480

ggcggtaagc ggcgacaacg ctgagccgct gctgcgcgcc gccgacctgc tgcagttccc      540

ggccgtgaag gaggcgtgcg gggccttcct gcagcagcag ctcgacctgg ccaactgcct      600

ggacatgcag gacttcgctg aggccttcag ctgctcggga ctggcgagcg cggcgcagcg      660

gttcattctg cgccacgtgg gcgagctggg cgccgagcag ctggagcggc tgccactggc      720

gcgcctgctg cgctacctgc gggacgacgg gctgtgtgtg cccaaggagg aggccgccta      780

ccagctggcg ctgcgctggg tccgcgctga cccgccgcgc cgcgccgcgc actggccgca      840

gctgctggag gccgtgcgcc tgcccttcgt gcgccgcttc tacctgttgg cgcacgtcga      900

ggccgagccg ctggtggcgc gctgcccacc ctgcctgcgc ctgctgcgcg aggcgcgcga      960

cttccaggcg gcgcgctacg accgccacga ccgcgggccc tgtccccgaa tgcgtcctcg     1020

cccgtccacc ggtctcgccg agatcctcgt gctcgtgggc ggctgcgacc aggactgtga     1080

cgagctggtc actgtcgact gctacaaccc gcagacgggt cagtggcgct acctggccga     1140

gttcccagac cacctgggcg gaggctacag catcgtggcg ctgggcaatg acatctacgt     1200

gacgggtggg tccgatggct cccggctcta tgactgcgtg tggaggtaca actcaagcgt     1260

gaatgagtgg gcggaggtgg cgcccatgct gaaggcccgc gagtaccaca gctcctctgt     1320

gctggacgga ctgctgtacg tggtggccgc cgacagcacc gagcgctatg accacaccac     1380

tgactcctgg gaggccctgc agcccatgac ctaccccatg gacaactgct ccaccactgc     1440

gtgccgtggc cggctctatg ccatcggctc cctggctggc aaggagacca tggtgatgca     1500

gtgctacgac ccggacaccg acctgtggtc gctggtggac tgcggccagc tcccgccctg     1560

gtccttcgcc cccaagactg cgactctaaa cggactcatg tactttgtca gggatgactc     1620

cgctgaggtg gacgtgtaca acccgacgag gaacgaatgg gacaagatcc cgtccatgaa     1680

tcaggtaaat tttcaggcgg gccagcattg gaagcacagg ctggtcctga ttttgcaacc     1740

caagtgtcat cgtgatgagt gtttgggatc cacagccatg atgggtgggt ctcatctcaa     1800

ttaatagaag gctgctctta cccttatttt gcacttaagg ctcactgaga cacagatgtt     1860

aagtaatacc ctatgattac acagcttagt acacatttga gcagtgttta ttgagtatct     1920

gctgtgagcc agagagcaga aggaagtgag ggagcaaggc atacagtcat ctggggacac     1980

ctgttccaga gagggacagc aggtacagag gccctgcagc agggcaccct ggcgtgttct     2040

tagatacacc agcagcccat gtggccggag cagagtcagc atgaggtctg tgacctacct     2100

tttttatttt tgagacaggg tcttgctctg tcacccaggc tggagtgcag tggtacaatc     2160

atggctcact gcagcctcca cctccttgac tcgcagtcct cccaccgcac cttcctgaat     2220

agctgagact acaggcgtgt gccaccacac ccagtaattt tttttctcat atgtagatac     2280

aaaaggatat tcttaaaatt tttatagaga cagggtcttg ctgtgttacc caggctggtc     2340

tcacactcct ggcctcaagt gaccctcctg tctcagcctc ccaaagtgct aggattatag     2400

gcgtgaacca ccacgcccag ctggttcctg aggaagtcag tgtgggaata cttttttttt     2460

ttttatacgg agtctcgctc tgtcacccag gctggagtgc agtggcacga tctcggctca     2520

ctgcaagctc catctcccag gttcacgcca ttctcccgcc tcaacctccc gagtagctgg     2580

gactacaggt acccaccacc acgcccagct aattttgttt gtgtattttt agtagagacg     2640

ggatttcact gtgttagcca ggatggtctg gatctcctga ccttgtgatc tgcctggctc     2700

agcctcccaa agtgctggga ttacaggcat gagccaccat gcccagccca ctgtgggaat     2760

acttgtgttg agcacttgct gtgtgttctg aataggacaa ccagggtcca ccccttctct     2820

ctgggcttgt tgagaagagg ggtgcccagc ctgacagtga tgggacaggg aggcttcagt     2880

gccatttggc catgtgagca gtgttagtct gaggtacaca tcatattgcc tacagccttc     2940

tttcctgtgt gtctgttaac atttccaaac ctacactccg tgacatccag cctcacagct     3000

tacatcacag cttaatgtcc tggcatttaa gagacccagc gttctgtttt ccccgcagta     3060

agctgcacat agtcatagcg aatttgggaa agatggaagg aatcatccag cctcgcggtt     3120

cagagcccag ctctgccact gtcagccatg caagcctcag ttttcccatc tgtaacatgg     3180

ggagaacagc actgctcagc ccagagggcc actgcagaga ttctgagaga gaacgtagga     3240

agcgctgctc ggcacgacct gcacacgggg aggcctggcg ctgcagcggg caccctcatc     3300

accataggga aggcccagct gcctccgggg aggcccgttc tcctaggcag ggtgttggaa     3360

aggggttggc ctctctgctg ctttctggga gagccaaggc cacccctctg gggtactgac     3420

agggcatgcc ttgtctccag tggttcccca ggtggggccc tgccctaccc tctcctctga     3480

cctccactca ctcatccctt tggcccacag gtacatgtgg ggggcagcct ggccgtcctt     3540

ggggggaagc tgtacgtctc tgggggatac gacaatacat ttgaactctc ggacgtggta     3600

gaggcctatg acccagagac tcgcgcgtgg agcgtggtgg ggcggctccc agaacccacc     3660

ttctggcatg gcagtgtcag catcttccgc cagttcatgc cccagacctt ctcgggtggg     3720

cgtggcttcg agttggacag tggcagcgat gacatggacc caggccgacc ccggccgccg     3780

cgggaccccg atgagctgca ctagccccag tctggcccgg cacgggcctc ggtgcaggta     3840

actggcacct ctgcggggca gtgccccact cctttgtgca caaggacacg ttgggctcac     3900

aggaggagca caggctcttg ggtggcgaag ccagcccagg atccattacc tggaaggttt     3960

ctgtaccttg agagcctgaa tcagaggccg tcgggaacgc cctccctgca gttgaggaag     4020

agccactttc ctgccagcac atgtttctgg gtcttggagg tcacccccac cccgcggatc     4080

acagctcacc cacgcggcgc acacccctcc tgccgttgtc atctgcacct acttgttccc     4140

accttgggag aggacgatga cttgggaggg acgcgtgaag ggagaagggg tcctcccatg     4200

aggctgagga tggcctgaac ctggagcagc ggaccaggca gacgggctga agtggggtcc     4260

caaattccat gtccagaggt gtggggagcc tgcctcccta gctcctggcc cctgccaggg     4320

gcttacatca aaacacctca gagggctgcc ctccagaggc tgcacccaga acagtgggac     4380

atgagcaggg gtgtgggctt ggagggtgaa gaggatgtgg tcctatcaga tgctgggcct     4440

cctcagccat agccccctgc tcctaccccc tgactggctc ttgcgtcctc acctctcacc     4500

ctctccttcc cgggaggccc tgggaggtga tcattgacac ccagccaagc agacagctgc     4560

gggtgcccaa gcccttgctg ggcctgcgcg tgaggagtcc cactgcttct aaaggaagtc     4620

ctgggcagga ggtggctttg gtggttggtt ccaaagttga aaatgcttgc agtttgacct     4680

tagaagaagt gggaagaaga aggagctcta cagggtcagc tttgtttgat ttgtccagtc     4740

taagaagtcc cattgccaaa gctttctgca ggagggtgaa tgccgcagct tggcagcccc     4800

tgggtttctc ttggaaatgg tcagtttccc ctcaaagtac ccaaagtagc cttggcttga     4860

gtttttgtcc ttgcctcctt tttagagaag agggcattta gactgcattt tcctggttaa     4920

agaaggttaa agcaaatgtt tattgccttt tctagtgaac taactcgtag agatgttctc     4980

agcaggaaga cagtcttagc actgtcactt agcagattgc acttaagtcc cttgtgctgg     5040

ccagatggcg tggctggttg ccttaatatg tcccaggacc cctgacaggg ctgcctggcc     5100

tctccctcgt gctcctcaag agcccagtcc atacactgtg gatgtcattg ctgtcgggtt     5160

aggaagtctt gtcctagaac gccctggctg gtatgaccac agttcatggc ggctcttctc     5220

gcttgggtca tggtcatctt ccagcacctg ctgtgctggg aaggccgagg atgggggccc     5280

agcactgtcc aggcctgctg gggcctggct gggagtcctg tgggcagcat ggaacatgca     5340

gctgggcttc ctgtgaccag gcaccctctg gcactgttgc ttgccctgtg ccctggacct     5400

tttcctgccc ttctccttcc tctgctccct tggggctacc ccttggcccc tcctggtctg     5460

tgcaaactcc ctcagggagc ccccctgccc tgtagctctc gcttaacttc ctaggggctg     5520

ctgagcccac ccagaggttg ttggagttca gcggggcagc ttgtctccct tgtcagcagg     5580

ggcgtaaggg ctgggtttgg ccatacaagg ttggctacgc cctcaatccc tgaccgttcc     5640

aggcactgag ctgggcaccc acggaaggac atgctgtcca gactgtgatg actgccagca     5700

cagggcatct cgggcttggc tggtctgcga ggccttgccc ctgtggaact ctgggttcct     5760

gttttctcag tcttttttgc ggctttgctg tggttggcag ctgccgtact ccaggcttgt     5820

gtcggccact cagatgaggg ctgtggtgcg agccagtgca ggagagctgc gcttgggatt     5880

gtgccctctc ctgtgtctgt cctccggacc tacccaggtc tccaccatca ggaccctgtc     5940

tttgggttta gaagaccaag tatggggaaa accaggcacc agcctctgca gcaatgggtc     6000

cctctagcct gtggacacca gctgggggat ccagggtcag gccccctcct ctccccagtt     6060

tccctctgct gtgggttctg ggctgtcatg tctccaccac ttaaggatgt ctttacactg     6120

acttcaggat agatgctggg atgcctgggc atggccacat gttacatgta cagaactttg     6180

tctacagcac aaattaagtt atataaacac agtgactggt atttaatgct gatctactat     6240

aaggtattct atatttatat gacttcagag acgcgtatgt aataaaggac gccctccctc     6300

cagtgtccac atccagttca ccccagaggg tcgggcaggt tgacatattt atttttgtct     6360

attctgtagg cttccatgtc cagaatcctg cttaaggttt tagggtacct tcagtacttt     6420

ttgcaataaa agtatttcct atcca                                           6445


<210> 2009
<211> 2293
<212> DNA
<213> Homo sapiens

<400> 2009
gggtacgcat agccgggcac taggttcgtg ggctgtggag gcgacggagc agggggccag       60

tggggccagc tcagggagga cctgcctggg agctttctct tgcataccct cgcttaggct      120

ggccggggtg tcacttctgc ctccctgccc tccagaccat ggacggctcc ttcgtccagc      180

acagtgtgag ggttctgcag gagctcaaca agcagcggga gaagggccag tactgcgacg      240

ccactctgga cgtggggggc ctggtgttta aggcacactg gagtgtcctt gcctgctgca      300

gtcacttttt ccagagcctc tacggggatg gctcaggggg cagtgtcgtc ctccctgctg      360

gcttcgctga gatctttggc ctcttgttgg actttttcta cactggtcac ctcgctctca      420

cctcagggaa ccgggatcag gtgctcctgg cagccaggga gttgcgagtg ccagaggccg      480

tagagctgtg ccagagcttc aagcccaaaa cttcagtggg acaggcagca ggtggccaga      540

gtgggctggg gccccctgcc tcccagaatg tgaacagcca cgtcaaggag ccggcaggct      600

tggaagaaga ggaagtttcg aggactctgg gtctagtccc cagggatcag gagcccagag      660

gcagtcatag tcctcagagg ccccagctcc attccccagc tcagagtgag ggcccctcct      720

ccctctgtgg gaaactgaag caggccttga agccttgtcc ccttgaggac aagaaacccg      780

aggactgcaa agtgccccca aggcccttag aggctgaagg tgcccagctg cagggcggca      840

gtaatgagtg ggaagtggtg gttcaagtgg aggatgatgg ggatggcgat tacatgtctg      900

agcctgaggc tgtgctgacc aggaggaagt caaatgtaat ccgaaagccc tgtgcagctg      960

agccagccct gagcgcgggc tccctagcag ctgagcctgc tgagaacaga aaaggtacag     1020

cggtgccggt cgaatgcccc acatgtcata aaaagttcct cagcaaatat tatctaaaag     1080

tccacaacag gaaacatact ggggagaaac cctttgagtg tcccaaatgt gggaagtgtt     1140

actttcggaa ggagaacctc ctggagcatg aagcccggaa ttgcatgaac cgctcggaac     1200

aggtcttcac gtgctctgtg tgccaggaga cattccgccg aaggatggag ctgcgggtgc     1260

acatggtgtc tcacacaggg gagatgccct acaagtgttc ctcctgctcc cagcagttca     1320

tgcagaagaa ggacttgcag agccacatga tcaaacttca tggagccccc aagccccatg     1380

catgccccac ctgtgccaag tgcttcctgt ctcggacaga gctgcagctg catgaagctt     1440

tcaagcaccg tggtgagaag ctgtttgtgt gtgaggagtg tgggcaccgg gcctcgagcc     1500

ggaatggcct gcagatgcac atcaaggcca agcacaggaa tgagaggcca cacgtatgtg     1560

agttctgcag ccacgccttc acccaaaagg ccaatctcaa catgcacctg cgcacacaca     1620

cgggtgagaa gcccttccag tgccacctct gtggcaagac cttccgaacc caagccagcc     1680

tggacaagca caaccgcacc cacaccgggg aaaggccctt cagttgcgag ttctgtgaac     1740

agcgcttcac tgagaagggg cccctcctga ggcacgtggc cagccgccat caggagggcc     1800

ggccccactt ctgccagata tgcggcaaga ccttcaaagc cgtggagcaa ctgcgtgtgc     1860

acgtcagacg gcacaagggg gtgaggaagt ttgagtgcac cgagtgtggc tacaagttta     1920

cccgacaggc ccacctgcgg aggcacatgg agatccacga ccgggtagag aactacaacc     1980

cgcggcagcg caagctccgc aacctgatca tcgaggacga gaagatggtg gtggtggcgc     2040

tgcagccgcc tgcagagctg gaggtgggct cggcggaggt cattgtggag tccctggccc     2100

agggcggcct ggcctcccag ctccccggcc agagactgtg tgcagaggag agcttcaccg     2160

gcccaggtgt cctggagccc tccctcatca tcacagctgc tgtccccgag gactgtgaca     2220

catagcccat tctggccacc agagcccact tggccccacc cctcaataaa ccgtgtggct     2280

ttggactctc gta                                                        2293


<210> 2010
<211> 1005
<212> DNA
<213> Homo sapiens

<400> 2010
tgacaccatg acccactgtt gctccccttg ctgtcagcct acctgctgca ggaccacctg       60

ctgcaggacc acctgctgga agcccaccac tgtgaccacc tgcagcagca caccctgctg      120

ccagcccgcc tgctgtgtgt ccagctgctg ccagccttgc tgccgcccaa cttgctgtca      180

aaacacctgc tgtaggacca cctgctgcca gcccacctgt gtgaccagct gctgccagcc      240

ttcctgctgc agcacaccct gctgccagcc cacctgctgt gggtccagct gctgtggcca      300

aaccagctgt gggtccagct gtggccagag cagctcctgt gcacctgtgt actgcagaag      360

aacctgctac taccccacga ctgtctgcct gcctggttgc ctaaaccaga gctgtggctc      420

caactgctgc cagccctgct gccgcccagc ctgctgtgag accacctgct gcaggaccac      480

ttgcttccag cccacctgtg tgtccagctg ctgccagcct tcttgctgct gatcacgttc      540

caagagaacc accatcctca cacaacaaat ttctgctcaa ctgactcatc ttttggggga      600

ctaatttaat ttgctgctga cagccaccat gctctcaccc aaatttttat gaattctcta      660

catgtttaaa atcttggaaa tctgcttgag ggagggcaga atacttcatc ctgattctct      720

ttttccttac accttgtgga tcatgtgcca gcttcatctg ttctcaagtt tgagtcatgg      780

tctcagcttt gactctaaag tcaagagctt cattccctgc ttctaaggaa tttaggtttc      840

tgcaactgat cgatgatctt tgcaatcttt tttttgtttt caatatcctc ctcatcgttc      900

ttgtatcctt ctttcttctt ttcatgataa atttgtgttg tgtccctggt agcagaaatc      960

cttacctata tgtttctgaa taaattctga accatcctca tctca                     1005


<210> 2011
<211> 597
<212> DNA
<213> Homo sapiens

<400> 2011
atggtcagct cctgttgtgg ctccgtgtgc tctgaccagg gctgcagcca agacctctgt       60

caggagacct gctgccgccc cagctgctgt cagaccacct gttgcaggac cacctgctac      120

cgccccagct gttgtgtgtc cagctgctgc aggccccagt gctgccagtc tgtgtgctgc      180

caacccacct gctgtcgccc ccctaggtgc tgcatctcca gctgctgccg ccccagctgc      240

tgtatgtcca gctgctgcaa gccccagtgc tgccagtctg tgtgctgcca gcccaccacg      300

acctgctgcc accctaggtg ctgcatctcc agctgctgtc gccccagctg ctgtgtgtcc      360

agctgctgca agccccagtg ctgccagtct gtgtgctgcc agcccaactg ctgccgcccc      420

agctgcagca tctccagctg ctgccgcccc tcttgctgtg aatccagctg ctgccgcccc      480

tgctgctgcg tgcgtccagt ctgtggccga gtctcctgcc acaccacttg ctatcgccca      540

acctgtgtca tctccagctg cccccgcccc ttgtgctgtg cctcctcttg ctgctga         597


<210> 2012
<211> 1812
<212> DNA
<213> Homo sapiens

<400> 2012
ttttgcagcc agtctctgtc tttgcttctg gaaggatgac ttctgactgc tcctccacac       60

actgctctcc tgagtcctgt ggcacggctt ccggttgtgc acctgcctca agctgctccg      120

tggaaacagc ttgtctcccc ggtacctgtg ctacatcccg atgtcagact ccaagcttcc      180

tatccaggtc tcgcgggctg actggttgcc tcctgccatg ctactttact gggagttgta      240

atagtccctg cttggtgggg aactgtgcct ggtgtgagga tggggtgttc actagcaatg      300

agaaggagac gatgcagttc ctgaatgaca gactcgccag ctatctggag aaggtgcgca      360

gcctggagga gaccaacgca gagctggaat ccaggatcca agaacaatgt gaacaggata      420

tcccaatggt gtgcccggat tatcagcgtt acttcaacac cattgaagat ctccaacaaa      480

agatcttatg cacgaaagca gagaattcta gacttgctgt acagcttgac aactgcaaac      540

tggccactga tgactttaag tcaaagtacg agagtgaact gtcccttcgc cagctgttag      600

aggctgacat cagcagcctg catgggatcc tggaggaact gaccctgtgc aaatctgatc      660

tggaggccca tgtggagtct ctgaaggaag atctcctttg ccttaagaaa aaccatgaag      720

aggaagtcaa cttgcttcgt gaacagcttg gcgaccgcct cagtgtggag ctggacactg      780

cccccaccct tgacctcaac agggtcctgg atgagatgcg ctgtcagtgt gaaacggtgc      840

ttgccaacaa tcgcagagaa gctgaagaat ggttggctgt tcagacagaa gagctgaatc      900

agcagcaact gtccagcgcg gagcagctgc agggctgcca gatggagatc ttggaactga      960

aacgcacagc cagtgctctg gaaattgagc tccaagcaca gcaaagcctg acagaatctc     1020

tggaatgcac cgtggcagaa accgaggccc agtacagctc ccagctggcc caaattcagt     1080

gtctgatcga taacctggag aaccagctgg ccgagatccg ctgcgacctg gagcgacaga     1140

accaggagta ccaggtgctc ctggacgtga aggcccggct ggagggtgag atcaacacgt     1200

actggggcct gctggacagc gaggacagca ggctttcctg tagcccatgt tcgaccacat     1260

gcacctcgag caacacttgt gagccatgct cagcctatgt catctgcact gttgaaaact     1320

gctgcttgtg aatgttaagg acagcaggta gaggaatcaa agccagcagc atcctagaaa     1380

ggagatgggg cttcaaccag ggacatccaa accggaagca caaatccagg aggctctcat     1440

atcctggaat tgccctccag gtatcctcag tctttctgct ttactatttc ctctccttcc     1500

ggcttatttg tggtatactg gaagcccata aagcattctt gctcatctcc aaataaaacg     1560

tgttttattc ctttagcgtg gtaaatatag ctctatggct gattactgtt gatagaatat     1620

tcattttatg gcaaggaaat catctaaacc cataaccata gtttcaatgt acataaaccc     1680

aggctgaaaa tattttttaa ctcctcaaat acaaataaat taatgaaccc atgagaaatg     1740

tcatatatct tagaaaatag ttgtgtgtat ctttctgagg aaaaatatta ggaataaaat     1800

atgataaaat gt                                                         1812


<210> 2013
<211> 1566
<212> DNA
<213> Homo sapiens

<400> 2013
agcatccggg ctcccggcag cggcgctgcg gcggctcgcg ggagacgctg cgcgcggggc       60

tagcgggcgg cggagcggac ggcgacgggg cgctctcggg ctgccggcgg ggccgagcgc      120

cgcgcgtccc gagcatggca ggctccctgc ctccctgcgt ggtggactgt ggcaccgggt      180

ataccaagct tggctacgca ggcaacactg agccccagtt cattattcct tcatgtattg      240

ccatcagaga gtcagcaaag gtagttgacc aagctcaaag gagagtgttg aggggagttg      300

atgaccttga ctttttcata ggagatgaag ccatcgataa acctacatat gctacaaagt      360

ggccgatacg acatggaatc attgaagact gggatcttat ggaaaggttc atggagcaag      420

tggtttttaa atatcttcga gctgaacctg aggaccatta ttttttaatg acagaacctc      480

cactcaatac accagaaaac agagagtatc ttgcagaaat tatgtttgaa tcatttaacg      540

taccaggact ctacattgca gttcaggcag tgctggcctt ggcggcatct tggacatctc      600

gacaagtggg tgaacgtacg ttaacgggga tagtcattga cagcggagat ggagtcaccc      660

atgttatccc agtggcagaa ggttatgtaa ttggaagctg catcaaacac atcccgattg      720

caggtagaga tattacgtat ttcattcaac agctgctaag ggagagggag gtgggaatcc      780

ctcctgagca gtcactggag accgcaaaag ccattaagga gaaatactgt tacatttgcc      840

ccgatatagt caaggaattt gccaagtatg atgtggatcc ccggaagtgg atcaaacagt      900

acacgggtat caatgcgatc aaccagaaga agtttgttat agacgttggt tacgaaagat      960

tcctgggacc tgaaatattc tttcacccgg agtttgccaa cccagacttt atggagtcca     1020

tctcagatgt tgttgatgaa gtaatacaga actgccccat cgatgtgcgg cgcccgctgt     1080

ataagcccga gttctttcag gtctgccaca ccaagaagga ctatgaagag tacgggccca     1140

gcatctgccg ccacaacccc gtctttggag tcatgtccta gtgtctgcct gaacgcgtcg     1200

ttcgatggtg tcacgttggg gaacaagtgt ccttcagaac ccagagaagg ccgccgttct     1260

gtaaatagcg acgtcggtgt tgctgcccag cagcgtgctt gcattgccgg tgcatgaggc     1320

gcggcgcggg cccttcagta aaagccattt atccgtgtgc cgaccgctgt ctgccagcct     1380

cctccttctc ccgccctcct caccctcgct ctccctcctc ctcctcctcc gagctgctag     1440

ctgacaaata caattctgaa ggaatccaaa tgtgactttg aaaattgtta gagaaaacaa     1500

cattagaaaa tggcgcaaaa tcgttaggtc ccaggagaga atgtgggggc gcaaaccctt     1560

ttcctc                                                                1566


<210> 2014
<211> 444
<212> DNA
<213> Homo sapiens

<400> 2014
gatttgcccc atgggcctaa gacataagct gaacctctgg cctgcagttc cagatccaag       60

gtgactgaga caaactgcca gctgccactg gcttatcagg agcacctgga gatggacaac      120

atgtctccca ggctgagagc cttcctctcc gaacccattg gagaaaagga tgtctgctgg      180

gtggatggca tcagccatga gctcgcgatc aatttggtca ccaaaggtat caataaggcc      240

tacatcctgc tgggacaatt ccttctgatg cacaagaatg aagccgagtt tcagaggtgg      300

ctcatttgct gttttggtgc cactgagtgt gaggcccagc agacttctca ctgcctcaag      360

gagtggtgtg cctgcttcct gtagacacaa acctcattgc tgccccccac caccctctgg      420

ggaaaatgac gccttctcca ccta                                             444


<210> 2015
<211> 2299
<212> DNA
<213> Homo sapiens

<400> 2015
gagacgcgct gtgtgattgc ctcggagaga ggaaggcgct ccagttccgg gtcaggccct       60

tctcccgcct ccctcggcct tagccatggc gagtagcagc ggtgctgggg cggcggcggc      120

ggccgcggcg gcgaatctga atgcggtgcg ggagaccatg gacgttctgc ttgagatttc      180

aagaattttg aatactggct tagatatgga aactctgtct atttgtgtac ggctttgtga      240

acaaggaatt aacccagaag ctttatcatc ggttattaag gagcttcgca aggctactga      300

agcactgaag gctgctgaaa atatgacaag ctgactttct ggagaaattc tgatgagata      360

tgtcaagctc tgcaagaggg tttgaagatt gcattgtagt tgagaatgta caatgaaatt      420

actgcatgca gcagtgtaga aaaattttac tttttaaaag aattataaaa ccatagcttt      480

ataaatcagt ggaaagtggc ttacagagag aactatcaga tgtgtttaca tcacatctta      540

ttcacttttt ttaacagctc taatgctttg gcattgctat gttcatattt atgtattcct      600

tatttatagc tctgatagct ttaattttct aagcagtctg tctatcagat gtgcacatct      660

gctgtgccag gttgaagtat agtggaaccc atcagtagta atgtgtagta gttatgactt      720

gttgacattt ccattataaa ctttaatttt gaattgttta tgcattataa ctgtggattt      780

atattgtatt gggctgaaag ttgacaggat ttcagccacc acttgtgaat ttttatttag      840

attcattatg tatatcagaa tcttgttttt tgaaataaga gcatggaaaa catttcttgt      900

aatctactct tgaacaaaga atatttagtt tttcaaacag tttgttgggc agctaatagt      960

gtgaaccagg tcatttttgt attgagtaaa aaaatcaaac tttgagaaac ttggatttta     1020

aaagtaatga caatgcttag gttagtatta tttgtaattt gaatcattta catctaatga     1080

gaatgttagt tgagaatgtt ttcttaaagt tttatatcct ataaataacg gaataaaaaa     1140

atttgtaaaa tgaaacaaca aacatgcaaa attcctattt acttttatta cataaaagta     1200

attttagtgc ttacctaata aatcttgaat ggttatttaa taaattatta gatgggtgat     1260

gtgtttcaaa agatacttgc tattttttga agaaataagg atttccagtc attaaacaaa     1320

actaaacaat cttattagat gggtgatgtg tttcaaagga tacttgctat tttttgaaga     1380

aataaggatt tccagtcatt aaacaaaact aaacaatcaa atgttctata ttaggaatct     1440

caagtatggc tttttttaaa aaaccttttt aacatcttga tgtcaaggat tataagtatg     1500

gcttttcaga attgttttgt ttgtcattat tcttgccttt aaaattttaa ctcatcaaag     1560

tgaagattag aaataaattt tagaaaatgt agaatagtat tgattctgtt cctgtaatag     1620

aatctcagtg gagttttttt gcaaaactaa tatggatttc atctgatttt attatttctt     1680

aaattttaga ttttattgag taccatttat atgattgtac aagcattcac tctttactag     1740

cattttttgt ttttcagaca agctgaagtg gttttattaa gatttggtaa tatttaaata     1800

gcaaccttct ctgccttttt ttttttttaa tatagaattt tgaccatttt gactttttaa     1860

atgcctggca tctttaccaa ccaagtaaac tggaagatct gttactggta gaacaggttg     1920

aggagacagt aggaatttgt aaaaagtcat ttgatttata atcaacacta caaatactat     1980

gtgttattta taaaatcata aagaacactt ttgtcagact ccaaaatttg tatatacttc     2040

caggccataa gagttgatag tattatttat gactttgtag attaagttat ttatgtatga     2100

aacaaagcag gaaaatatat tgagaaggga tcgtgtttac agaggacttc tttaaagtgt     2160

cacattttta aaatgtaaac atatttttaa tgcatactta agtaatattt aagaaactaa     2220

acaaaataat gatacaattg cagtgttgtg cttgttgtca atgacaaaaa taaaaccatt     2280

ttggtggtat tggcctgta                                                  2299


<210> 2016
<211> 4597
<212> DNA
<213> Homo sapiens

<400> 2016
agactccatc cgccatgttg gatgccgcag attcgccata acctcgccgg ctcttttctt       60

aaaaaaataa aaataaaaag cgaagcgtca gcagggcgcc ccgccccctc ggtcggcacg      120

ggagggggcc cggaagagcc cgaggctttt ttttcctccg cggtggggcg ttgccatgga      180

gacgcgggcg gcagaaaaca cggccatctt tatgtgtaaa tgttgtaacc tcttctcacc      240

aaatcagtcg gaactcctct cccacgtttc agagaagcac atggaagaag gggttaatgt      300

tgatgagatt attattcccc ttaggcctct gagtacacct gaacccccca actcaagcaa      360

aaccggagat gagtttttgg tcatgaagag gaagagaggc aggcctaagg ggtccacgaa      420

gaagtccagc acagaagagg agctggcaga aaacatcgtg agtccgactg aggacagccc      480

gctggctccg gaggaaggga acagcctgcc tccaagcagc ttggagtgta gcaagtgctg      540

tcggaagttc tccaacacgc gccagctgcg gaagcacatc tgcattatcg tgctgaattt      600

gggtgaggag gaaggagaag caggtaacga gtctgacctt gaactagaaa agaagtgtaa      660

ggaagatgat cgggaaaaag cctcgaaaag accacggtca cagaaaacag agaaagtcca      720

gaagatctca ggaaaggagg ccagacagct ttctggggcg aagaaaccca tcataagtgt      780

ggttttaact gcacacgaag caattccagg tgctaccaag attgtgccag tggaggctgg      840

gccccctgaa acaggagcta caaattctga gaccacttca gcagacctgg tgcctcggag      900

aggctaccag gaatacgcca ttcagcagac accttatgag caaccaatga agtcaagcag      960

gctaggtccc actcagctca aaatcttcac ttgtgaatac tgcaacaagg tcttcaagtt     1020

caagcactcg ctgcaggccc acctgaggat ccacaccaat gaaaagccat acaagtgccc     1080

ccagtgcagc tatgccagtg ccatcaaggc caacctcaat gtgcacctgc gcaagcacac     1140

tggagagaag ttcgcctgcg actattgctc gttcacctgc ctgagcaagg gccacctcaa     1200

ggtgcacatc gagcgagtgc acaagaagat caagcagcac tgccgcttct gcaagaagaa     1260

gtactctgac gtcaagaacc tcatcaagca catccgagac gcgcatgacc cacaggacaa     1320

gaaggtcaaa gaggccttgg acgagctctg cctgatgacg agggagggca agcggcagct     1380

gctctatgac tgccacatct gtgagcgcaa gttcaagaac gagctggacc gtgaccgcca     1440

tatgctggtc cacggagaca agtggccttt tgcctgtgag ctctgtggcc atggggccac     1500

caagtaccag gcgctggaac tgcatgtcag gaagcacccc ttcgtgtacg tctgtgccgt     1560

ctgccgcaag aagttcgtca gctccatcag gctgcgcacc cacatcaaag aggtgcacgg     1620

ggctgcccag gaggccttgg tcttcaccag ttccatcaac cagagcttct gcctcctgga     1680

acctggtggg gacatccagc aagaagctct gggggaccag ctacagctgg tggaagagga     1740

gtttgccctc cagggcgtga atgcactcaa ggaagaggcc tgtcctgggg acactcagct     1800

ggaggagggc cggaaggagc cggaggcccc tggggaaatg cctgccccag ctgtgcacct     1860

ggcctccccg caggccgaaa gcacagccct gccaccctgt gagctggaaa ccaccgtggt     1920

ctcctcctca gacctgcatt ctcaagaggt ggtttcagat gattttttgt tgaaaaatga     1980

tacctcctcc gcagaggctc atgctgctcc tgagaagccc ccagacatgc agcacagaag     2040

ctcagtccag acgcaaggtg aagtgatcac actactgctg tccaaggccc agagtgctgg     2100

gtcagatcag gaaagccatg gcgcccagag ccccctaggg gaagggcaga acatggctgt     2160

gctttcagct ggtgacccag atcccagcag gtgtctcagg tcaaacccag ctgaggcctc     2220

agacctcctc cctccagtag ctggtggtgg ggacaccatc acacatcagc ctgactcttg     2280

caaagctgcc cctgagcacc ggtcaggcat caccgctttc atgaaggtcc tgaacagttt     2340

acagaagaag caaatgaaca ccagcttgtg tgagcggatc cggaaggttt atggagacct     2400

ggagtgtgaa tactgtggca aacttttttg gtaccaagtg cattttgata tgcatgtccg     2460

cacccacacc cgggaacatc tgtattattg ctctcagtgt cattattctt ccatcaccaa     2520

aaactgcctt aaacgccacg taattcagaa acacagtaac atcttgctga agtgtcccac     2580

cgatggctgt gactactcaa ctccagataa atataagcta caggcacatc ttaaagttca     2640

cacagcactg gacaaaagga gttattcttg tcctgtttgt gaaaagtctt tttcagagga     2700

tcgattgata aagtcacata tcaagaccaa ccatcctgag gtctccatga gcaccatttc     2760

tgaggttctc gggaggaggg ttcagctgaa agggctaatt ggaaagagag ccatgaaatg     2820

cccatattgt gacttttatt tcatgaagaa tggctcagac cttcagcgtc atatttgggc     2880

tcatgaaggt gtgaagccct tcaagtgttc tttgtgtgag tatgcaactc gtagcaagag     2940

taacctcaag gctcatatga atcgtcacag cactgagaaa acccacctat gtgacatgtg     3000

tggcaagaaa ttcaaatcaa aagggacact gaaaagtcac aaactccttc acactgcaga     3060

tgggaagcag tttaagtgca cggtgtgtga ctacacagcg gcccagaagc cacagctgct     3120

gcggcacatg gaacagcatg tctccttcaa gcctttccgc tgtgcccatt gccattactc     3180

ctgcaacata tctggctctc tgaagcggca ctacaacagg aagcacccta atgaggagta     3240

tgccaacgtg ggcaccgggg agctggcagc ggaggtgctc atccagcaag gtggtttgaa     3300

gtgtcctgtt tgcagctttg tatatggcac caaatgggag ttcaataggc acttgaagaa     3360

caaacatggc ttgaaggtgg tggaaattga tggagacccc aagtgggaga cagcaacaga     3420

agctcctgag gagccctcca cccagtatct ccacatcaca gaggccgaag aagacgttca     3480

agggacacag gcagcggtgg ccgcgctcca ggacctgaga tacacctctg agagtggcga     3540

ccgactggac cccacggccg tgaacatcct gcagcagatc attgagctgg gcgccgagac     3600

ccatgacgcc actgcccttg cctcggtggt tgccatggca ccagggacgg tgactgtggt     3660

taagcaggtc accgaggagg agcccagctc caaccacacg gtcatgatcc aggagacggt     3720

ccagcaagcg tccgtggagc ttgccgagca gcaccacctg gtggtgtcct ccgacgacgt     3780

ggagggcatt gagacggtga ctgtctacac gcagggcggg gaggcctcgg agttcatcgt     3840

ctacgtgcag gaggccatgc agcctgtgga ggagcaggct gtggagcagc cggcccagga     3900

actctagagg acatgtggca tcggatggcc acagggcggg gctgccaggc tctgcaggca     3960

cccagggtgg ggaggccacc cttcctgccc tacccgcaga atggtgctct cctttgccct     4020

ccctgcccag cagcctgata ggactctcct agtccaactt ggggtgggca aggcagtcag     4080

catcaccagc aataccacag gaccctcacc ccagcataga cacacacccc ctgaccctta     4140

ccatctgctt cctgaaagac ttcagtgtca gctcccctac acacacccca caccttcacc     4200

ccttgcttca agattcaaac agagactccc agtccccctc agcatcttcc ctgaatcaca     4260

gccccagctc cttgaccccc atctaggtgc caaatgttca tctgcaaccg ctatgcagtc     4320

tggtgagagg gagacagcca tcacatagaa agtgaccgta cgggttttta atcactgctg     4380

ggtggggtgg gggtaggggg attgtcctgg ctttgtcgac aaagtcccac ttccccgagt     4440

attaagggcc cttggtatca agtgaggtaa attcacccat cacagggtct cgccctacca     4500

tcctggaatt atttcacttt taagataaat gcactatttc actgttcgcc tcccattcta     4560

aggaggtgag gtggttggaa taaaaacagt tcctgtc                              4597


<210> 2017
<211> 5847
<212> DNA
<213> Homo sapiens

<400> 2017
agcgcggccg aagggcgtgg ttggcgctcg gtcctgccct gcgcgttttg ggctgcggtt       60

ggagggccgc agttgcagtc agggtccgcc agctcggggc cagcgcatgg ggctgctgag      120

accgctccgg acgtgcgaag cgttcgcggt gcggtaggaa gctgaagtct tcagcagaac      180

cctgacctag gtagggagtc tcaatggccc tgggtgaaga aaaggcagaa gcggaagcat      240

ctgaagacac aaaggcccag tcctatggga gagggagctg cagggagcgg gagctggaca      300

tcccagggcc catgagtggg gagcagcccc cacgcctgga agctgaggga gggctcatct      360

cccctgtatg gggggcagaa gggatacctg cccctacttg ctggattggg actgaccctg      420

gcggcccctc tagagcccac cagccacagg ccagtgatgc caacagagag cccgtagctg      480

agaggtctga gcctgcactc agtggcctgc ctcctgccac catggggtct ggagaccttc      540

tgctctccgg ggaaagccag gtggagaaga ccaagctttc ttcctccgag gagttccctc      600

agactctgag ccttcccaga acaacaacta tttgctcagg acatgatgct gataccgaag      660

atgatccatc cctagcagat ttgccccagg cactggacct cagccagcag cctcacagct      720

caggtctctc ttgcctgtca cagtggaagt ccgtgctgag cccaggttcc gcagctcagc      780

cttccagctg cagcatctct gcttcctcca caggcagcag tctccagggt caccaggaga      840

gggcggagcc tcgtggtggt tctctggcca aggtctcctc ctccctggag ccggtcgtcc      900

cccaggaacc ttcctctgtg gtggggctag gacctcggcc ccagtggtca ccacagcctg      960

tgttctctgg gggtgatgct tctgggctag gcaggagacg cctctccttc caggctgagt     1020

actgggcctg tgtgctgcca gattccctgc ctccatcacc cgaccgccac tcccctctct     1080

ggaacccaaa taaagagtat gaagatctgc ttgactatac ttacccactg aggcccgggc     1140

ctcagctccc aaagcacctt gatagccgtg tgccagctga ccctgtcctg caggactccg     1200

gggtagacct ggatagcttc tctgtctctc cagcaagcac cctcaaatca cctactaatg     1260

tctcccccaa ctgcccacca gcagaggcca ctgccctgcc attttctggg cccagagagc     1320

caagccttaa gcagtggccc tccagagtac cccagaaaca gggtggcatg ggcttggcat     1380

cttggagcca acttgcatct acccccagag ccccaggcag tagggatgct cgttgggagc     1440

gcagagagcc agccctgagg ggtgcgaagg accggctgac tataggcaag caccttgata     1500

tgggctctcc ccagctaagg acacgggaca gagggtggcc ctcgcccagg ccagagaggg     1560

agaagaggac cagccagagt gcccggcgcc ctacctgcac agagtctagg tggaaatcag     1620

aagaggaagt ggaaagtgat gacgagtatc ttgccctccc cgctcggctg acacaggttt     1680

ctagcctggt ttcgtatcta ggatccattt ctaccttggt taccctgccc actggggata     1740

tcaaagggca gagccccttg gaagtgtcag acagtgatgg gccagcttcc ttcccttcaa     1800

gctccagcca aagccagctt ccccctggag ctgccctcca aggatctggg gatcctgagg     1860

gccagaatcc ctgtttcctg cgctccttcg tccgtgccca cgactccgca ggggaaggca     1920

gtctggggag cagccaggcc ctcggggtct cctctggact gctgaaaaca cgcccctcct     1980

tgccagctag gttggaccgg tggccattct cagacccaga tgttgaaggg cagcttccca     2040

ggaaaggagg agaacaggga aaagaatcac tggtgcaatg tgtgaagaca ttttgctgtc     2100

agctggaaga gctgatctgc tggctgtata atgttgcaga tgttactgac cacgggactg     2160

cagccaggtc caatcttaca agtctcaagt cttctctgca gctttaccgg caatttaaga     2220

aagatataga tgaacatcag tctctgacgg agagtgtctt acagaagggg gagattcttc     2280

ttcagtgcct gttggagaac accccagttt tagaggatgt ccttgggagg atcgcaaagc     2340

agtctggtga gctggagagc cacgcagatc gcctgtatga ctctatcttg gcctctctgg     2400

acatgctggc tggctgcacc cttatccctg acaaaaagcc catggcggca atggagcacc     2460

catgtgaagg ggtttaacct ggcatcttct caggcagagg tgcaacctgt cggccaaaca     2520

ctggctagtg agaaaaaaaa ccttcaagaa gtccttgcaa gagccattca acactgaagt     2580

caagggggaa accttcaata tactagcttt aaaatgcctt tctcctccct gaatggaggg     2640

ctgagttact atttttattt acaatgaatc cttccaaact aaggttttcc ttttggtgct     2700

tctccacaaa gagcgtgtag ctttgcaatt tttgataaaa taagacgtgt tgccttcccc     2760

tctatcccat taaaaaagag cagataaagc tcaaactatt ccacctggta gggtcattta     2820

ccaagggctg gtaggagatt ccgaatactc aatattctca ggcatgcaag aggacctaag     2880

agactgaaaa aagtgaattg ttggccagaa accttgggtc ttttcataaa aggaaatttg     2940

ggcttgtcaa tccctcttta aagatatagg tagaaagaag agatttttaa ccctttgtct     3000

gcaaaagaaa aagggttaaa tgaagcatct atacagatga ctttgggaga ttatgacacc     3060

ttttgccatc ttcagggctt acgtctttac tttcttggct aaccagtttc ttagaagaaa     3120

atgtgtcagg gacttgggga tctacagtca tgctttagca tggctatgga gctaattatc     3180

aagcttaaag ggtaactttg ggaggactcc tcccttcact cctagtctcc cttggaagag     3240

cagtccaggc tcagggaagg gaacggatag gatgacacag taagtacaga aactgaagct     3300

gtcaatagtg aaggaaaaag gggaattctt cgttgctttg gcattgacac ataagtactt     3360

tgattaaaaa aaaaaaaaac tatggatcaa ccattcaaag catcaattct atagcttttt     3420

gcagcaagat gatcagttat tgctggtaac tgcagattct acagaaaagc acttttaaag     3480

ttctgttggg ccatgaatga acctggaagg aggaaagcac agtaacaatg gaaactaaag     3540

tcctattatt aatgtgactt ttctgcttca gaatttctga gactttatag tcactggaaa     3600

atagccatta aattctttaa agattagctc ttcaacagta gctacacata aaatgcagta     3660

tttcaagtgc ctgatgctgc tgtggtatgc tttatcataa tgcttaaggg catgatcaaa     3720

attaaaatgg cttatgagtt tgccatatta atcatcttag ttccatacac actgagactt     3780

taaaagggaa aaaccactct agcaaataat tgtcaattat aaacctgtat gtaaaacatt     3840

cttgaaaacc tagagttggt taaaaaggta gagatgtctg acggcctctt cttaaattga     3900

tatattttac cttctcttag atgtacattt ataagtagga acatgtcctt ccactgagta     3960

tgttactgaa tagcccttag gaaattaaac ccatttattt actaatattt gacaggcata     4020

gaagtgtatt aattagcata aaagttggag atgaaaaccc tatagaaaca aattggccaa     4080

tattatacta attgaatgca gaatgtggca ttctattccc attcaactaa taatcagctt     4140

caactgacag gaatttgcac agaatgttac acaataccct gtttcccaag aaagtactac     4200

cttacctaga gatgatctaa gatatttttg ttcatcctct gaataaggtg agactaaagg     4260

gtgctaactc cctggacctg gctgtgaatg ctactgaaga gtatcaacac aactgttaat     4320

tataccgccg tgctttaagt ttaagactta ccttaaaact caagctgaag gctgggcacg     4380

gtggctcatg cctgtaatcc cagcactttg ggaggccgag gcgggtggat cacaaggtca     4440

ggagatcgag accatcctgg ctaacacggt gaaaccccat ctctactaaa aatacaaaaa     4500

gaaattagcc aggcgtggtg atgggcgcct gtagtcccag ctacttggga ggctgaggca     4560

tgagaatggc atgaacccgg gaggcggagc ttgcagtgag ctgagatggc accactgcac     4620

tccagcctgg gcaacagagt gagactcttg tctcaaaaaa aaaaaatcaa gctgaaattg     4680

tttcagccta gtaagatgct gccagcagca tttctatgag caaacatggc caaattagag     4740

tcaagtagct gagcttgcta actgcactgt gatgccacac tggaataact tagtagtccc     4800

ttaaaattaa tggaagttaa atccacaggg aagtgatgat actcaaagct ggatcagcag     4860

tttcaagatc tgggttcttg gagatccata ggtaagctca gcaaatggaa gacgacgtca     4920

acacggctat tttgaagctt aggtgggaat ggaacacaaa gaaggtttga ggtaagatat     4980

gctggaaagg caagatgtag gctaagggaa attcaatcca aggtcgaaga ataggaaatt     5040

actgctcaga ccacaatgac tatcattctg aaaggatttc acagagtgtg cagctgctta     5100

gatttaagaa cactcttctt cactatgtaa actaatttat ggcagcacct tatatttaga     5160

acaagtggta attcccttta ctaagtgaac agattattaa aacctgtagt agctttgaac     5220

cgtttgtact tgaaaatggg ggtataaagg ggtatatatt ttttccagaa ccacatttat     5280

tggcgtatac atagaagcaa atcttaaggc atgctgaaat ttgttgtaaa tcccaatctt     5340

tactgccatg gggaaaagaa cgctggaatt ttccaaactt aagtctgtaa atatgctcat     5400

cttaagttca tgtaatgttt ccgctaactc accaagaata agctgacaat ttaaacaact     5460

tttactgtgt aaaaatgaag tgcacggcat ggcatcacag tatcttgaca tttgttttgt     5520

gtcatttagc tactttagaa aatagtttct gaactctttc cccctttata ctgtattaag     5580

gcaaaaacaa aacttctgaa gcattaaaga tcttcaccaa aataactatt ggtaacttca     5640

ggaatttgtc agttgcctta tgtgaggatg aatagatcca ccaagcacgc ctataataca     5700

aagtaaacta tgatttttat tgtgaaattt tcatagatgg aaaattgaat attctgtcca     5760

tttcatttta caattatctt accacttatt tttgtaccat gtatttcaat tgcctgttta     5820

gtgaaaaata aaaattaaaa aaaccta                                         5847


<210> 2018
<211> 653
<212> DNA
<213> Homo sapiens

<400> 2018
gacgcgcggg gccacactgc ccgcccccta gcctggcgct gggcctccgg gacaagttgg       60

ctgggtccgg gcttggggac tgcaacgcgg tcttctgtgc ttcaccatct acataatgaa      120

tcccagtatg aagcagaaac aagaagaaat caaagagaat ataaagaata gttctgtccc      180

aagaagaact ctgaagatga ttcagccttc tgcatctgga tctcttgttg gaagagaaaa      240

tgagctgtcc gcaggcttgt ccaaaaggaa acatcggaat gaccacttaa catctacaac      300

ttccagccct ggggttattg tcccagaatc tagtgaaaat aaaaatcttg gaggagtcac      360

ccaggagtca tttgatctta tgattaaaga aaatccatcc tctcagtatt ggaaggaagt      420

ggcagaaaaa cggagaaagg cgctgtatga agcacttaag gaaaatgaga aacttcataa      480

agaaattgaa caaaaggaca atgaaattgc ccgcctgaaa aaggagaata aagaactggc      540

agaagtagca gaacatgtac agtatatggc agagctaata gagagactga atggtgaacc      600

tctggataat tttgaatcac tggataatca ggaatttgat tctgaagaag aaa             653


<210> 2019
<211> 688
<212> DNA
<213> Homo sapiens

<400> 2019
gatgctgctc tttaggatgg acctgggcat accctagtat ctgtttattt tgctttttct       60

ggtgactatt taatccagga caatatgttt agaaatttta aaccagtttt agaaattggt      120

ttaaaataca ttaatttcat tttttcagct ataattatta tgtgtgtata tatgtaaaat      180

atagatatca agagtcatta actttagtca ccttagtcat tgacagggct gagtttggat      240

taagagagaa aaaataatag ttctactgta caatagtata atttttatga ttgtaagtat      300

tttaaaccta gactccacct tcgggggtgc aaaccatatt gttttttaat tactagtctt      360

ctgtgcttca ccatctacat aatgaatccc agtatgaagc agaaacaaga agaaatcaaa      420

gagaatataa agaatagttc tgtcccaaga agaactctga agatgattca gccttctgca      480

tctggatctc ttgttggaag agaaaatgag ctgtccgcag gcttgtccaa aaggaaacat      540

cggaatgacc acttaacatc tacaacttcc agccctgggg ttattgtccc agaatctagt      600

gaaaataaaa atcttggagg agtcacccag gagtcatttg atcttatgat taaagaaaat      660

ccatcctctc agtattggaa ggaagtgg                                         688


<210> 2020
<211> 3220
<212> DNA
<213> Homo sapiens

<400> 2020
gcgccgagtc ccagcatgca ccgcgcccgg ccggctctgc ctttgggggc cagcagggct       60

gtacctggga gttgggttgg ggcggagcgg aggggaggcc gtgccaggca gggccggttc      120

gtgcggaacc gccatggccg agccggcttc ggtaactgtg acatttgatg atgtggcctt      180

atatttttcg gaacaagagt gggagatcct ggagaagtgg cagaagcaaa tgtataagca      240

agagatgaag accaattacg agacccttga ttccctgggg tatgcttttt ccaagccaga      300

tttgatcaca tggatggaac aagggagaat gctattaatc agcgaacagg gatgcttaga      360

taaaacaaga aggacaacta gccctcctac tgatgaacag ttgaacatga agaatactgg      420

aaagttgcta tgttttgatg acgaaggaac tcccaggaca aaagaagagg attgccgttt      480

aaatggtcct caaaaacagg acttgtgtgc tgccttacga gggaaagaga gaaagatttt      540

attagctcaa acagccacct tccagtctcc aagtctccga gaaacagaga ttctaaataa      600

aaaagtcagc atcacagcat atgatccaga caagaaagac ctgcggcata agcctcggga      660

gaccccaggg cgcttagaaa ttcccacagg gccaagatgc tattcctgct atgtctgtag      720

gaaagtcttc caagtaagga gggatttgct aaagcacaaa cggagccact ccaagagcca      780

gctctgcaga tacccaaagt acaaaaactc gtccagaggg aagtccgaac tcaggcggac      840

gcagaggctc ctgtgtcaga agaagcggtt ccagtgcagt gagtgtgaga agagctactt      900

cctgaagggc agcctcgtca ctcatcaggt tgtccacacc ggccagcggc cctacccatg      960

ccctgagtgc gacaagacct tccggtacag ggccaacctg aagaagcacc tgtgtctaca     1020

ccgcggggag cggccgttct gctgcgggga gtgcggccgg gccttcgtgc agcagtgcga     1080

gctcacggag cacttgcggc tgcacagcgg agagaagccc ttccagtgtc cgcagtgtga     1140

ccggtgcttc cgcctgaaga ggggcatgaa ggtccatctg acccagcaca gcgggaagag     1200

gcccttccac tgtcccgagt gtggccggag cttctcccgg aaggctgccc tgaagaccca     1260

ccagaggacg cacagcgagg aaaagccgtt ttcttgtggt gaatgtggca ggaaattcat     1320

ctacaagatt aagctggacg agcacatcag agttcacacg ggagagaagc ccttttcgtg     1380

tcccgagtgt aacaaaagtt tccgcctcaa gagaagcctg aaagcccacg ggctgcagca     1440

cattgggaag cggcccttcc agtgcccgga gtgcagcagg ggcttcttct ggaggaacgc     1500

catgcgcgcc caccagcgcc tgcacagcga gcaaaagccc ttcccctgcg ccgagtgcgg     1560

caagcgcttc acgcggcctt ccaagctcgc ctgccacacc agagtccacg acaggcagaa     1620

ggagtttccc tgcggcgagt gcaaaaagac cttttctcag cagtcgcggc tcacgcagca     1680

cctgaaggtc cacaccacgg aaaagccgtt ctcctgcgcc gagtgcggcc gcagtttccg     1740

ccgacgcgcg catctcacag agcacacgag gcttcacagt ggcgaggagc ccttccagtg     1800

tcccgagtgc gacaagagct tctcctggaa ggcctccatg aagttccacc agcggatgca     1860

cagggacgag aagcccttcg cgtgcggtga gtgtgacaag acctacacgc atcagtctca     1920

gctcaccgag cacctgaggc tgcacagtgg agagaagccc taccagtgtc ctgaatgcga     1980

gaagactttc cgcctcaagg gaaacctgaa aagccacctg ctgcagcaca gtggccaaaa     2040

gccattctct tgtgtgatgt gcggcaaaag tttcactcaa cagtaccggc tcacagaaca     2100

cattcgagtc cacagcgggg agaagccctt ccagtgtccg gagtgtgaca agagctactg     2160

catcaggggc agcttgaagg tccacttgta taagcacagt ggagagaggc ccttccagtg     2220

tcccgagtgt ggcaaaggct tcctccagaa gagaagcctg aaggcccatc tgtgccttca     2280

cagtggggag aggccttttt cttgtgatga gtgtggaagg agcttcacgt acgtgggggc     2340

gctcaagacc cacattgcag tgcatgccaa agagaagccc tccagcctct aggtcaggcc     2400

atgcagcagt cacgcagtcg gctttcagga ggtgccagca gctctgttgg ctcaagttga     2460

ggcaggttga aggattcaca gggtaagatc gggcacagtg gctcccgcct gtaatcccat     2520

tactttggga ggcccaggtg ggaggatcgc ttgagcccag aagtttgaga ccagcctagg     2580

caacattgca agactccatc tctacaaaaa atataaaagt cagccaggcg ttgtggtgca     2640

tgcttgtggt cccagctact ttgggaggtt gaggcaggag gatcgcttga gcccaggagg     2700

cagaggctgc agtgagccat gctcacacca ctgcactcca gcctgggtga cagagcaaga     2760

tcttgtctca aaaaagaaaa aaaatcacaa aatactggct acagacacac tggacaggtg     2820

tgtggtctgc agaactctat ggctccttga caaaagttcc aaataatcca tagacagtca     2880

aagagacatc tccctcaata atcgtcatag gaaagacgtg ccagttgtgg aggaaacatt     2940

cacactgatc tgctagtcca acgatctctt cagtgtcatc caataatccc ttcattaaat     3000

tcagaaacta cagcctgagt gaagaaatgt tacagccagg aacatattcc tcagtcagct     3060

tttccattac caggccattt tacttaaatc tgtattaaag tcttcagttt tctctcatag     3120

tggattttca ttttctctca gatggtgaga gggcttctgt ttcttggaat gtttccatat     3180

tgctaaaaat aaatgtcttc cactatctca tttgttaaaa                           3220


<210> 2021
<211> 3101
<212> DNA
<213> Homo sapiens

<400> 2021
cgccatgcag agcactgacc taggcaacaa ggagagcggc aagatatggc accgcaagcc       60

gtccccggcc acgcgggacg gaattatagt gaacattatt cacaacactt ccgattacca      120

tccaaaagtt ttgcgatttt tgaatgtggc ttttgatggc acaggcgact gcttaattgc      180

tggggaccac caaggaaata tttatgtttt tgacttacat ggaaacagtc accaaggagc      240

tagttagctg gatgagagga catgaatcat cagtattttc gatctctgtg catgcatcag      300

ggaaatatgc catcacaact tcttctgata cagcacaatt atgggacttg gatacctttc      360

agagaaaaag aaagctgaat attcgccagt ctgtgggtat acagaaggtt ttctttctac      420

cattaagtaa taccatcctc agctgtttta aagataattc catttttgcc tgggaatgtg      480

acacactttt ttgcaaatat caattgccag ctccacctga aagctctagt atattataca      540

aagtgtttgc tgtaaccaga gatggccgaa tcctggctgc tggaggcaag tcaaatcatc      600

ttcatttgtg gtgcttggaa gctaggcagc tctttagaat tatccagatg cccactaaag      660

ttcgagccat tcgccatctg gaatttcttc ctgatagttt tgatgctggt tctaatcagg      720

ttcttggagt actaagtcaa gatggtatta tgagatttat caatatgcag acttgtaaac      780

ttctctttga gattgggagc ctcgatgaag gaattagctc atcagcaatt agcccacatg      840

gacggtacat tgcatctatt atggaaaatg gaagtctaaa catatattca gttcaggctt      900

taacacaaga aataaataag ccacctccgc ctttagtgaa agttattgaa gatttgccca      960

agaataaact gagttccagt gatcttaaga tgaaagtaac atcagggaga gtacagcagc     1020

cagcaaaatc tagggaaagc aaaatgcaaa ctagaatatt aaaacaagac ctgactggtg     1080

attttgaaag taaaaagaat gaattaccag atggattaaa caaaaagcgt ttacaaatct     1140

tattaaaagg ctatggtgaa tatccaacaa aatacagaat gttcatttgg cgctctctgc     1200

tacaactgcc tgaaaatcat actgcgttta gtaccctcat agataagggg actcatgtgg     1260

catttctcaa ccttcagaag aaatacccca tcaaaagtag gaagctactc agagtattac     1320

agagaacctt atctgcatta gctcactggt ctgtcatttt tagtgacaca ccatatcttc     1380

cactcttggc atttccattt gtaaaattat tccagaacaa ccaactcatc tgttttgaag     1440

ttattgctac tctcataatc aattggtgtc aacactggtt tgaatatttt cctaatcctc     1500

ctatcaatat tcttagcatg atagaaaatg ttttggcatt tcatgacaag gaactgctgc     1560

aacacttcat agatcatgat ataacctccc agctatatgc atggcctctt cttgaaactg     1620

tgttctcaga agtgctgaca agagaggagt ggctgaaatt gttcgataat atcttttcca     1680

accatccttc cttccttctg atgactgttg tagcctacaa catatgttct agaacgcctc     1740

tgctcagctg taatcttaaa gatgactttg agtttttttt tcaccatcgg aataacctgg     1800

atataaatgt tgtgattaga caagtttatc atctcatgga gaccacgcct actgacattc     1860

atccagacag catgcttaat gtttttgttg cactgacaaa agggcagtat ccagtattta     1920

atcaatatcc aaagtttatt gtggactatc aaacacagga acgagaaaga ataaggaatg     1980

atgaattgga ttacttaaga gagagacagt tgaagatatg caagctaaag tcgaccagca     2040

aagagttgaa gatgaagctt ggtaccagaa acaggagctg cttcgtaaag ctgaagaaac     2100

aagaagagaa atgctcttac aagaggagga gaaaatgata caacaaagac agaggctagc     2160

tgctgtgaaa agagagctga aagtaaagga aatgcactta caagatgctg caagaaggcg     2220

ttttctgaag cttcagcaag atcaacagga aatggaacta agaagactgg atgatgaaat     2280

tgggagaaag gtatatatga gagatcgaga aattgctgcc acagccagag acctagaaat     2340

gagacagctg gaactcgaat cacaaaagag actttatgag aagaatctta ctgaaaatca     2400

agaagctctt gcaaaagaaa tgcgagcaga tgcagatgcc tatagacgaa aagtggatct     2460

tgaagaacac atgtttcata agctgataga agcaggtgaa acccagagcc agaaaactca     2520

gaagtggaag gaagctgaag gaaaagagtt ccgtttgaga tcagcaaaga aagcttctgc     2580

tctttcagat gcgtctagaa agtggttttt aaagcaagag ataaatgcgg ctgtagaaca     2640

tgctgaaaat ccatgtcata aagaagaacc caggttccaa aatgaacagg actcaagctg     2700

tttgcctaga acctcacaat taaatgactc ttctgaaatg gatccctcaa cacagatttc     2760

tttaaataga agagcagtag aatgggacac cacgggacag aatcttatta agaaagtgag     2820

aaatcttcgc cagagactca ctgcccgggc tcgtcacaga tgtcaaaccc ctcatctttt     2880

ggctgcatag aatgcatgtc accttgagac ggtcgagaga gagacctatt ttgcaatcag     2940

tgacattgat ttttagatta tttatttaaa attcctataa agatcagccc tttgtacaga     3000

aaaatgtgtc tataaaaatt atgtgttatt taattctgat actttttggc ttgtaaatgg     3060

cttcttgaac tttttacaat aaaaatgttt tagaaactgt t                         3101


<210> 2022
<211> 1121
<212> DNA
<213> Homo sapiens

<400> 2022
cccagggctg ggcttggttg tcatgagagt ggaggctgcg gccggggcta tgggcagagg       60

tggccgggtc tgcttcttcc ctgtcactgc cgcagcagct tggggtgcaa ggcggcctgg      120

ggcggcggaa ggggcgcccc ccgagttccg tctgaggaag cggcggctgc cgaggaagtc      180

cacgagagcc gggtcccgca cgcccctggg gtccgggtgc tgaggcgccg cctggccgcc      240

tccccgggcc gcggcaccgc tccgacccag ccgccctctc caccggggcc gcggcagcgc      300

cagtcggggc ccttccctct aagcagccca aacgtgcaga atgccccaca agattggatt      360

tgtagtcgtc agctcatctg gacacgaaga cggcttcagt gcccgggagc tcatgatcca      420

cgcgccaact gtcagtgggt ggcggtcacc tagattttgc cagtttccac aagaaattgt      480

ccttcaaatg gtggagagat gtcgaataag gaaactgcag ttacttgctc accagtatat      540

gatttcaagt aaaattgagt tctacattag tgaaagcttg cctgaatatt ttgcacccta      600

tcaagcagag cggtttcgaa gacttggcta cgtgtctctc tgtgataatg aaaagacagg      660

ttgcaaagcc cgggaactaa aatcagttta tgtggatgca gtaggacaat ttcttaaact      720

gatttttcac caaaaccatg tcaacaaata caacatatat aatcaggttg ctttggttgc      780

cataaatatc attggagacc ctgcagattt cagtgatgaa agcaatactg cctctcgaga      840

gaagttgatt gaccactacc ttgggcacaa cagcgaggac cctgctctag aaggaacgta      900

cgccagcagt gtaagaaccg ggggtgaatc cacttttggg gagctaaagg gccccgctgt      960

gccatcctcg gtcaccctct ctgtcctggg cacctctttg ggacagtggt tcccttgcca     1020

cctgcctgct gtggatgaca atgaggggac tccattccag aggtgcctgg tctaaaggaa     1080

agaagggaag ggctgccata gttgccgcag tgagaaaaaa a                         1121


<210> 2023
<211> 6424
<212> DNA
<213> Homo sapiens

<400> 2023
ggttgtcatg agagtggagg ctgcggccgg ggctatgggc agaggtggcc gggtctgctt       60

cttccctgtc actgccgcag cagcttgggg tgcaaggcgg cctggggcgg cggaaggggc      120

gccccccgag ttccgtctga ggaagcggcg gctgccgagg aagtccacga gagccgggtc      180

ccgcacgccc ctggggtccg ggtgctgagg cgccgcctgg ccgcctcccc gggccgcggc      240

accgctccga cccagccgcc ctctccaccg gggccgcggc agcgccagtc ggggcccttc      300

cctctaagca gcccaaacgt gcagaatgcc ccacaagatt ggatttgtag tcgtcagctc      360

atctggacac gaagacggct tcagtgcccg ggagctcatg atccacgcgc caactgtcag      420

tgggtggcgg tcacctagat tttgccagtt tccacaagaa attgtccttc aaatggtgga      480

gagatgtcga ataaggaaac tgcagttact tgctcaccag tatatgattt caagtaaaat      540

tgagttctac attagtgaaa gcttgcctga atattttgca ccctatcaag cagagcggtt      600

tcgaagactt ggctacgtgt ctctctgtga taatgaaaag acaggttgca aagcccggga      660

actaaaatca gtttatgtgg atgcagtagg acaatttctt aaactgattt ttcaccaaaa      720

ccatgtcaac aaatacaaca tatataatca ggttgctttg gttgccataa atatcattgg      780

agaccctgca gatttcagtg atgaaagcaa tactgcctct cgagagaagt tgattgacca      840

ctaccttggg cacaacagcg aggaccctgc tctagaagga acgtacgcca ggaaatctga      900

ctatatctct ccgctagatg acttagcttt tgatatgtac caagatccag aagttgcaca      960

gatcatacga aaattagatg aaagaaaacg ggaagctgtc caaaaggaac gctatgatta     1020

tgccaagaaa ctaaaacaag ccattgctga tttgcaaaag gttggtgaac gccttgggag     1080

gtatgaggta gagaaacgct gtgccgtgga gaaggaagac tacgatctcg ccaaggagaa     1140

gaagcagcag atggagcagt atcgtgccga ggtgtacgag cagctggagc tgcacagcct     1200

cctggatgcc gagctgatgc gaagaccttt tgatttgccc ctccagcccc tcgctcgttc     1260

tggcagtcct tgccaccaaa agccaatgcc ctcactacca caactggaag aaagaggaac     1320

agaaaaccag tttgcagaac ctttccttca ggaaaagcct tcatcatatt ctctaactat     1380

ttctcctcag cattctgcag tagacccgtt actccctgcc acagatcctc atccaaagat     1440

caatgcagag tccctgccct acgatgagcg gcctcttcca gctattcgta agcattatgg     1500

ggaggcagtg gtggagccgg aaatgagtaa tgcagacatc agcgatgctc ggaggggagg     1560

catgttaggg gagccagagc ccttaaccga gaaggccttg agagaagcca gctctgccat     1620

cgatgtgttg ggagaaacct tggttgctga ggcctattgt aagacgtggt cctaccgaga     1680

ggatgcactg cttgccttgt ctaagaagtt aatggaaatg cctgttggaa ccccaaaaga     1740

agatttaaag aacacactga gagcatccgt ctttctcgtt agaagagcca taaaggacat     1800

tgtgacctcc gtttttcagg cttctttgaa attgttgaaa atgatcatta cacaatatat     1860

tcctaaacat aaactgagta aacttgaaac agctcactgt gtggagagga ccattcccgt     1920

tttgctcacc agaactggag attcttctgc ccgcctccgc gtcacagctg caaattttat     1980

tcaggaaatg gccttgttta aagaagttaa gtctctccaa attattccat cctacctggt     2040

gcagccattg aaagcaaact cttcagttca cctggcaatg agtcagatgg gcctcctggc     2100

ccggctgctg aaagacctgg gcactggcag ctcgggcttc accattgaca acgtgatgaa     2160

gttttcagtg agtgccctgg agcatagagt gtatgaggtc cgcgagacgg cggttcgaat     2220

tattttggac atgtacagac agcaccaggc ttccatcctg gagtaccttc ctccagacga     2280

cagcaacaca cgcaggaaca ttctctacaa aacaattttt gagggatttg ctaaaataga     2340

tggcagagct acagatgctg agatgagggc acggagaaaa gcggctacag aagaagcaga     2400

aaaacaaaag aaagaagaaa taaaagcttt acaagggcag ctggcagcac tgaaagaaat     2460

tcaggctgaa gttcaggaaa aagaaagtga tgctgtgaag ccaaagaatc aggacattca     2520

aggagggaaa gcagcccctg ctgaagctct gggaatcccg gatgagcact atctagataa     2580

tttgtgtatt ttttgtgggg aaaggagtga atccttcaca gaggaaggtc tggatctcca     2640

ctactggaag cactgtctca tgctgacaag atgtgaccac tgcaaacagg tggtcgagat     2700

atccagtctg acggagcact tgctgacgga atgtgacaaa aaagacgggt ttggaaagtg     2760

ttaccgttgc agtgaggctg ttttcaagga agagctgccc agacacataa aacacaagga     2820

ttgcaaccct gccaaaccgg agaagctggc aaaccggtgt cccctgtgtc atgagaactt     2880

cagccctgga gaagaggcat ggaaagctca cctgatgggc ccagccggct gcacgatgaa     2940

cctgcgcaag acacacattc tgcagaaggc cccggcactg cagccaggga aaagctcagc     3000

tgtggccgca tcaggcccct tggggtcaaa ggccggaagc aagatcccca ccccgaaggg     3060

cggactgagc aagagctcca gcaggacgta cgccaagcgc tgacgcggcg ctcgggctcc     3120

ttggtctctg tgagggatgg agcgggtctc ctgattctac accatctctc cagaactctc     3180

tggccttggt ggccccatgc tctggctgct gtccccagct ccccgccgtg cacgcctctt     3240

acgcgtctgt gccgtcagct ctcgtgcaaa cgatatggat gcagctaacc aaagatcctg     3300

cgtgcagtgc caggacctgg ccgcactgta cattaagcct tcagggctgt ctcaggcctt     3360

ccttagaatc agagaaggaa gcgtcctgtt tggagagagc cagagagcac cgccgggagg     3420

cgctcgcgca aggccacggt cagcacaggc acggtcccgc tttccttagt gcttggagca     3480

atttccataa aacattcacc agaaaccttt tgcacatcgg tctctgccac acgcagtaga     3540

atttccgcag ggctgtggct cggccagcag cggttccagg agagtggcgg tgcgcacggg     3600

cctccagccg tgccttcccc ctgcaggccc cgtctgctgg gcctgctgcc cagtgcactc     3660

agccccaggt agcagaactc acgttcccac tatagcaaga aataaaggca aaagagaaca     3720

tctttttttt aatcgtagtt tttttgagaa ttggtcccac ctcagccgca ccttgctgga     3780

tgcttctcca gtagtgctgc ccctgtgaca ggcatcagct ccctgctgga actgaggtag     3840

acacaggtgt gggcccttcc cgtgcctttg ctcagaggcg cttcactttc tccacacttt     3900

cgaattccta aagacatgtg gaggaagtca ctgttaaatg aatttccacc tgatcaccct     3960

gtgttcacag caggcagaag cccactggta tgggcctccc gccccttcca catccatgtt     4020

gtgattggat ccataagttt actttcttca aagagttgat aggatgttta aaacatcaac     4080

acattgctta aaatgatgaa accaaccctc aaaaaacagt ctcctaacca gccatcccct     4140

cctgtgggag tgagctgggg gttttgtcca tagctttggt tgggcctgtg tcacatccag     4200

gcagccatgt ggagggagtc agggtctgtc tggaagcatc caccctctcg ctgccccagc     4260

ctgtgctccc aggggcctag gctaccatgg actgaagggc agtcccctcc cacctggtgc     4320

ccagggcttc tgcttgcctc gctgatgttg catgggcaga cttcaaaaag gatagttaga     4380

aaggtttggg ttgatggagt ttgcattaat gcaattagtg tataaatatg ttttaattgc     4440

caaccgtgtg aaacaacaaa atatctaaaa actaatcccg atttgaacaa tgtactccct     4500

ggcctggata cattaataac cataaatttg catgaattaa tctccacgtt tggtaaacta     4560

atacctctgg ttgactgaga atactgagta agatataaga cctaccagga acctttaaga     4620

atatgctctg ctcagtgttg tttgtctgct tgtttgcgac ggagtctcac tgtgtcgccc     4680

gggctgcagt gcaatggcgt gatcttggct cacagtaacc tccacctcct gggttcaagc     4740

aattctcctg cctcagcctc cctagtagct gggattacag gtgcacacca ccatgctcgg     4800

ctaatttttt ctatttttag tagagatggg gtttcaccat gttggccagg ctggtctcga     4860

actcgtgacc tcataatctg cccaccttgg cctcccaaag tgctgggatt acaggcgtga     4920

gccaccacgc ccaggttaaa tgtgtttata aggagagagg aggccaggcg cggtggctca     4980

cgctgtaatc ccagcacttt gggaggccga ggcgggcgga ccacctgagg tcaggagttc     5040

gagaccagcc tggccaacat ggtgaaaccc catctctact aaaaatacaa aaatgagcca     5100

ggcgtggtgg cctgtagtcc cagctacttg agaggctgag gcaggaaaat tgcttgaacc     5160

cgggaggtgg aggttgcatt gagcccacat catgccattg cactccagcc caggcgacag     5220

agcgagactc cgtctcgaaa aaaaaaaaaa gtataaggag agaaataact ttaaagttta     5280

ttagacaaaa cagagtatag atgccaagat gtctgtaaaa tgattttttc tggttttaaa     5340

gagatgttgg ccattatttt ctaatccatt tttaaaatac agacaaaaca cttctttaaa     5400

cagaacaaga atgagaaaag ttaaccaagg aattattctt ttctcaccaa tcaacacttt     5460

taagaaatat atatatatat atacacacat atacacatgc cttctatata ttgtaactta     5520

aagaaaatac ttataaaaag acttcatttt tagtgattga caagcaaacg ggttcattta     5580

aaacaggttc ctcttttgtt agttacaggg ggtttttttg ttgttttttt gtttttgttt     5640

ttgttttgcg ggggtggtgg ggtttgagac ggagtcttgc tctgttgcct aggctggagt     5700

gcagtggcgc gatcttggcc ccctgcaacc tccgcctccc gggttcgagc aattctcctg     5760

cctcagcctc ccgagtagct gggattacag gcgtgtgtca ccacgcctgg ctaatttttt     5820

tgtattttta gtagagacgg ggtttcacca tattggccag gctggtctca aactcctgac     5880

cttgtgatcc acccacctcg gcctcccaaa gtgctggaat tacaggcatg agccaccgcg     5940

cccggcccaa tcatgtgttt ttgttgaaat gatcctacca gtgattagtg gctattgaga     6000

gttttacagg gttatacatt gttaagggac caagaatcaa gtacaaaaaa ttaaaaagga     6060

actgtaaaat cccttggtca ttcataaata aatatctaaa ttaggaatac taattaattg     6120

aattttcact catgagtatg ttctgaatat ttaatattta tttctattat tttcatatgt     6180

taagatattc cattaaatct aacttaaaag aattgtatgt ataaattggc attaggatac     6240

aaatgtaaat gtttttaatg aaattttgca actttttaat attttaacat agttttctat     6300

ttgtctttat ttcaagtacc agaattacaa aatatctaag taatatattt ttgttgtcgt     6360

tttagggctt aagggttaat tcacccagag tatattaata taataaaaag atcactaaat     6420

gttt                                                                  6424


<210> 2024
<211> 3244
<212> DNA
<213> Homo sapiens

<400> 2024
cgcggctgca tggacgcggg tccggcgcgc gggaggcgat gacggccccg ccatggcccg       60

ggcgggcagc tgcggcggcg ccgcggcggg cgcagggcgg ccggagccct gggagctgtc      120

cctggaggag gtgctgaagg cctacgagca gccgctcaac gaggagcagg cgtgggccgt      180

gtgcttccag ggctgccgcg ggctgcgggg ctcgccgggc cggcgcctgc gggataccgg      240

ggacctcctg ctgcgcgggg acggctcggt cggggcgcgg gagcccgagg ccgcggaacc      300

tgcaaccatg gtcgtgccac tagccagctc ggaagcccag accgtgcagt ccctcggctt      360

cgccatctac cgcgcgctgg actgggggct ggacgagagc gaggagcgcg aactcagccc      420

tcagctggag cggctcatcg acctcatggc caacaacgac agcgaggaca gcggctgcgg      480

tgccgccgat gagggctacg ggggtcccga ggaggaggag gaggccgagg gcgtcccccg      540

cagcgtgcgc acctttgccc aggccatgcg gctgtgcgcg gcgcggctga ccgacccccg      600

gggcgcacag gcgcattacc aggccgtgtg ccgcgcgctc ttcgtggaga cgctggagct      660

gcgggccttc ctggccaggg tccgggaggc caaggagatg ctgcagaagc ttcgggagga      720

cgagccgcat ctggagacgc ctcgggcaga gctggacagc ctgggtcaca cagactgggc      780

ccgactgtgg gttcagctca tgcgggagct ccgccgcgga gtgaagctga agaaggtgca      840

agagcaggag ttcaaccccc tccccaccga gttccagctc acgcccttcg agatgctgat      900

gcaggacatc cgggcccgga actacaagct gcgcaaggtc atggtggatg gggacatccc      960

gccccgggtg aagaaggacg ctcacgagct catcctggac tttatccgct cacggcctcc     1020

actgaagcag gtctctgaga ggcggctgcg cccgttgcca ccaaagcaaa ggtccctgca     1080

tgagaagatc ctggaggaga tcaagcagga gcggaggctg cgcccggtgc ggggcgaggg     1140

ctgggctgcc cgcgggtttg gctctctgcc ctgcatcctc aacgcctgct ccggagatgc     1200

caagtccacc tcctgcatca acctgtcagt cacagatgct gggggcagcg cccagcgccc     1260

gcggccccgc gtgctgctca aggcgcctac cttggctgaa atggaagaga tgaatacatc     1320

tgaggaagaa gagtctccgt gtggggaggt gacgctgaaa cgggaccgct ccttctcaga     1380

gcatgacctg gcccagctcc gaagtgaggt ggcctctggc ctgcagtcgg ccacccaccc     1440

cccaggaggg acggagccac cacggccccg agctggcagt gcgcatgtgt ggaggcccgg     1500

ctcccgagac cagggtacct gtcccgcgag tgtctctgac cccagccacc ccctactcag     1560

caaccggggc tcctcggggg acagacccga ggcctccatg acccccgatg ccaaacacct     1620

gtggctggag ttcagccacc ccgtggagag cctggcgctg actgtggaag aggtgatgga     1680

cgtgcgccgt gtgctggtga aggccgagat ggaaaagttt ttgcagaaca aggagctctt     1740

cagcagtctg aagaagggga agatttgctg ctgctgccgg gccaagttcc cgctgttctc     1800

gtggccgccc agctgtctct tctgcaagag agccgtctgc acttcctgta gcataaagat     1860

gaagatgcct tctaagaaat ttggacacat ccctgtctac acactgggct ttgagagtcc     1920

tcagagggta tcagctgcca aaaccgcgcc aatccagaga agagacatct ttcagtctct     1980

gcaagggcca cagtggcaga gcgtggagga ggcgttcccc cacatctact cccacggctg     2040

tgtcctgaag gatgtctgca gtgagtgcac cagctttgtg gcagacgtgg tgcgttccag     2100

ccgcaagagc gtggacgtcc tcaacactac gccacgacgc agtcgccaga cccaatccct     2160

ctacatccct aacaccagga ctcttgactt caagtgacag ccccaggtgg ccaggcctcc     2220

aggaggcacc aggcaggccc tgtatcaggc taggacgctc tgagctgtgc atgtacatat     2280

atacatatat agatacattt ataatatata cacacagtct atatatttat atacactgtt     2340

tcctggcccc agagctcatt tgggttcagg cgcacttcaa aaccctccct gggggaggct     2400

gtttcttctc aggattcctt gccagggagg aaggggaggg aacagggtgg gttttctcac     2460

tgaagagaga aagcagaagg ttctagatcc tggcacagac tgcatcccat gttcccatgc     2520

tcttctccgt ccccaggaat gcgaacggca gtttcccttc cccagtggac gtctaggtgg     2580

ggacagggta tcttggctcc cagctggacc agagtgccct gcttgcctct gctctccctt     2640

tgtggggact caggcagcag aggcatctgg gaagtctctg agtaggcagg gtcctcctgg     2700

gaggcacccc cacctgtttg aaaggtctgg ccaggcgtgg tggttcaggc ctgtaattcc     2760

agcactttgg gaggccgagg agggaggatc acctgaggtc aggagtttga gaccagcctg     2820

gccaacatga tgaaatgttg tctctactga aaatgcaaaa attagccagg tatagtggca     2880

ggaacctgta atcccagcta caggggaggc tgaggcagga gaatcgcttg aacccgggag     2940

gtgtaggttg cagtgagccg agattgcacc actgcactcc agcctgggcg acagagcgag     3000

actctgtctc gaaaaaaaaa aaggtccgtg ccaagctgct ccctgccctt gccctttccc     3060

tttccctggg gtccaaacca catgtgtcct gcctctcctg gccctaccac attctggtgc     3120

tgtcctcact cgcccctggc ccagaggctc ctgaagatgc tgggcggtcc tggcacaggg     3180

aggagcagct ctgtaaatct gtgcacatgg ccactcttgg cctaataaag gaggtctcac     3240

agtc                                                                  3244


<210> 2025
<211> 1998
<212> DNA
<213> Homo sapiens

<400> 2025
gcgcccaggg gtcccgcggg ttttcgggcg cagggtggcg cccgcggcag gcggcggcca       60

tgaacttctc cgaggtattc aagctctcca gcttactctg caagttctcc ccggacggca      120

agtacctggc ttcctgtgtc cagtaccggt tagtggtccg ggatgtgaac acccttcaga      180

tccttcagct gtacacgtgc ctagaccaga tccagcacat cgagtggtcg gcagactcgc      240

tcttcatcct gtgcgccatg tacaagcgag ggctggtgca ggtctggtct ttagagcagc      300

ccgaatggca ctgcaaaata gacgagggct cagccgggct ggtggcctcg tgctggagcc      360

cggacgggcg ccacattctc aacaccacgg aattccatct gcggataacc gtctggtcct      420

tgtgcacaaa atccgtgtct tacatcaaat acccgaaagc ttgtctgcag ggaatcacct      480

tcaccaggga cggccgctac atggcgctgg cagaacggcg cgactgcaaa gattacgtga      540

gcatcttcgt ctgcagtgat tggcagctcc tgcggcattt tgatacggac acccaggatc      600

tcacagggat tgagtgggcc ccaaacggct gtgtgctggc agtgtgggac acctgcttgg      660

agtacaagat tctgctgtac tcattggatg gccggttgtt gtccacgtac agcgcttacg      720

agtggtccct gggcatcaag tctgtggcct ggagccccag cagtcagttc ctggcagttg      780

ggagctatga tggaaaggtg cgcatcctta atcacgtgac ttggaaaatg atcacggagt      840

ttgggcatcc tgcagccatt aatgatccca agatagtggt gtataaggag gccgagaaga      900

gcccacagct gggactgggc tgcctctcct tcccgccgcc ccgggccggg gccggccctc      960

tcccgagctc agagagtaaa tatgagatcg cctctgtccc agtctcctta cagacactga     1020

aacctgttac cgacagagca aacccgaaaa tcggcatagg aatgctggca tttagtcctg     1080

acagctactt cctggcgaca aggaacgaca acattcccaa tgccgtctgg gtctgggaca     1140

ttcagaagct gaggctgttc gcggtgctcg agcagctgtc cccagtgcgc gcatttcagt     1200

gggacccgca gcagccgcgg ctggccatct gcacgggagg cagcaggctc tacctgtggt     1260

ccccagcggg ctgcatgtcg gtgcaggtgc ctggggaagg taagcacatc cccgaggcca     1320

cggacgtggc agccttgctg tgtgcagtct ggcatcacac gggctgaact gttgaagccc     1380

agctgctgtc tccggcagca ctccagggaa actgccctca gagtctttgc gtaaacctca     1440

agacggacac acaggggacc cgctgccctc agctttatgg gctagaagca gcctctccct     1500

gacttgaggc agctctgggg ctccaccctg gctctgccta tgtgggtcac tccaggcact     1560

gtgctggcct gcaggacaag ggggtgccca tcccccagaa tctgggcctc ccctgctgta     1620

atcctctggc cacctgtctc tctctaggcg actttgcagt gctctctctg tgctggcatt     1680

taagcggaga ctcgatggcc ctcctcagca aggatcactt ctgcctctgc ttcctggaga     1740

cagaggcagt ggtcggcaca gcctgcagac agctgggcgg ccacacgtag cagcggtgca     1800

ctaacgtgtg cagaaacagg gctactctgt gtttccagtg tgggaaaaaa cacagcttca     1860

ccaggaggtt ctccactgtg gtggtctgga ttcagtgatt gattctattt ttctatagca     1920

aagcattttt gtaaatatgt atggtataaa actgtagttt tattatttaa aataaatact     1980

tgctgattta tacaacta                                                   1998


<210> 2026
<211> 2414
<212> DNA
<213> Homo sapiens

<400> 2026
gggtggtggc ggtggctgcg gcgacggcgg tcgcgtcggc gtcagggtcg gggtcggtaa       60

ggggtgcggc aatgctgcaa ctgcgggact cggtggactc ggccggtacg agccccacgg      120

cggtgctggc ggccggcgag gaggtggggg caggcggcgg cccgggcggg gggcggccgg      180

gggcggggac gccgctgcgc cagacactct ggcctctcag catccacgac cccacgcgcc      240

gcgcccgcgt caaggagtac ttcgtgttcc ggcccggcag catcgagcag gcagtggagg      300

agatccgcgt ggtggtgcgg cccgtggagg acggcgagat ccagggagtg tggctgctta      360

ccgaggtgga tcactggaac aatgagaagg agcggctggt gctggtcacg gagcagtccc      420

tgcttatctg taaatacgac ttcatcagtc tccagtgcca gcaggtggtg cggatagcgc      480

tcaacgcagt agacaccatt tcctacggag aattccagtt tccccctaaa tcgctcaaca      540

agcgagaagg ttttgggatt cgaattcagt gggacaagca aagtcgtcct tccttcataa      600

acagatggaa tccctggtct accaacgtgc cctatgccac tttcacagaa cacccgatgg      660

ctggcgcaga tgagaagaca gcatctctgt gtcagttgga aagcttcaag gctctgttaa      720

tccaagctgt caaaaaagcc caaaaagaaa gccctttgcc aggacaggcg aatggcgtgc      780

tgatcctgga gcgccccctg ctcatcgaga cctacgtggg actcatgtcc ttcattaaca      840

acgaggcgaa actgggctac tccatgacca ggggcaaaat aggcttttag ccgctgcgtt      900

ctgggagctc ctcccccttc tgggagctcc tccccctccc cagaaggcca agggatgtgg      960

gggctggggg actgggaggc ctggcagtct tcatgctgcc ctgctgctgc tggaaggatg     1020

gggatctttc acctttaggg atctcagcac aattagaatc gtaaagtgaa ttctatctat     1080

ttaattggat attggactct gctcatataa gctacagaca aaagccaaaa gactctcgct     1140

gtccctgtgc tgctggtatt tcattctctg taacttcagt tctggtgttt tccttgagta     1200

tctacttggc ttctcgtggt ttttcccacc ccagctgccc cagcacgcgg gacccatagc     1260

acacccctta gcgcttgcct aggttgctga aaacagggag gcacctggta tctcgagtgc     1320

ctgcagttgc aagtatgttt acacctggtg tccaattttg tattttaaaa tgtaatccat     1380

ttttacttca gctcatccaa aagcagccag cagaccggtt gactgagacc ggtctgtggc     1440

tgtgggcccc ttggtgaccc gctgctcttt tggaaatggg tgacctgaag tgacactttt     1500

tccacaatta acccaagttg tgttaatact tcaggtctgt ttcccagacc cagaaagctt     1560

tacagaaaat cattgtaaga caatttatta atttgagaaa gtcaccttga cagttctttg     1620

cacacaagtt ttacacctct ctggattcga agtttgtatt gtattcatag ttaaagggaa     1680

tcgggtactt tgcttgttga ataatgcact ttaaaacaag gaaccgtatc aggccagcat     1740

ggtggctcat gcctgtaatc ccagcatttt gggaggctca ggcagacaaa tcgctctagc     1800

tcagaagttg cagagcagcc tgggcaacat ggtgaaaccc gtctctacca aacagacaaa     1860

aagcagccag gcgtggtggc acatctgtgg tcccagctac ttgagaggct gagccaggag     1920

gatcgcttga gcccaggagg cggaggttgc agtgagctga gatggcacca cttattgcac     1980

tccagcccgg gcgacagagc gagactccat ctaccagatc cttatgacgc agctgatgcc     2040

tgccttggtt cctaccactc tggtgtagac agaggacttt gtccaagtct cacactaaac     2100

atgcccgggc ttcgatgtgc ctggaggatt tccccacagg gacccacgca cctccctgta     2160

tctgcgcagc ttgctcgtgt ggctggaagc gctgtcgata agcttcacgc actggcttgc     2220

cagttcttca gctctaggac ttgtagcttt aagcaaacgg tgtggcatgg gttgagtgtg     2280

gccacctgca ggatgtgcag ggctgcctca gaagctggct ggggactcta gcctctgtgt     2340

tcataaagac attaagaagt ggatggatgt tgttcctttt ttgaagttgt cattaaagta     2400

ggtgcaacaa ccaa                                                       2414


<210> 2027
<211> 870
<212> DNA
<213> Homo sapiens

<400> 2027
atgtggccct tcccgagccg ctctctcttc ccacccccga ctcaggcctg gctccagacg       60

gtctcctcag accctgaggc ccagggctgg ggggcctgga acgagaccaa ggagattctg      120

gggccagagg gtggggaagg gaaggaggag aaagaggagg aagaggatgc agaggaagac      180

caggatgggg atgcaggctt tctgctgtct ctgctggagc aagagaacct ggctgagtgc      240

ccattgcctg accaggagct ggaggccatc aagatgaagg tgtgtgccat ggagcaggcc      300

gaggggacgc cacggcctcc aggagtgcag caacaggccg aggaagagga gggcaccgcg      360

gccgggcagc tgctgagccc tgagaccgtg ggctgccccc tctctgggac ccccgaggag      420

aaggtggagg ctgaccacag atccgtctac gtgggcaacg tggactacgg gggctccgcc      480

gaggagctgg aggcccactt cagccgctgt ggggaggtcc accgagtcac gatcctgtgt      540

gacaagttct ctggacaccc caagggttat gcctacatag agtttgccac caagggctcc      600

gtgcaggccg ccgtggagct ggaccagagc ctcttccggg gccgggtcat caaggtgctg      660

ccgaaaagaa ccaacttccc tgggatcagc tccacagacc gcgggggcct tcgaggacac      720

ccaggctcca ggggggcacc cttcccccac agcggcctcc agggcaggcc ccggctcaga      780

ccacaagggc agaaccggac gccggcggca ctgacgccac tatgggctcg gccgctgccc      840

tgggtggtag tcagccacgt catcaagtga                                       870


<210> 2028
<211> 2219
<212> DNA
<213> Homo sapiens

<400> 2028
cccatttcag gtgggacttg tggcatagga gaggtcttgg gactggtgcc cagcctgggg       60

cagtcccctc ccaaagcctc cctctcccac acagccgtga gagcctgtgg gcctagagga      120

ctcagctggc gggttgcagg gaggcgcagc cttttgcaat cccccagggc cacaggttac      180

cctccttctc tctctagacc cccagctcta ccaggagatc caggagcggg gcctgaacac      240

cagccaggag tctgatgacg acatcctcga tgagtcctcc agccccgagg gaacccagaa      300

ggtggacgcc accattgtgg tcaagagcta ccggcccgcc caggtcacct ggagccagct      360

cccagaggtg gtggaattgg gcatcctgga ccagctctcc actgaggagc ggaaaaggca      420

ggaggccatg ttcgagatcc tcacgtcgga gttctcctac cagcacagcc tgagcatcct      480

ggtggaggag ttcctgcagt ccaaggagct gcgggcgacc gtgacccaga tggagcacca      540

ccacctcttc tccaacatcc tggatgtcct gggtgccagt cagaggttct tcgaggacct      600

ggagcagcgg cacaaggccc aggtgctggt cgaggacatc agtgacatcc tggaggagca      660

cgctgagaag cacttccacc cctacatcgc ctactgctcc aacgaggtct accaacagcg      720

cacgctgcag aagctgataa gcagcaacgc cgccttccga gaggccctga gagagattga      780

gaggcggccg gcgtgcgggg gcctgcccat gctctccttc ctgatcctcc ccatgcagcg      840

ggtgacccgg ctgcccctcc tgatggatac gctctgcctc aagacccagg gccactccga      900

aaggtacaag gctgccagcc gtgcactgaa ggccatcagc aagctggtga ggcagtgcaa      960

cgagggggcc cacaggatgg agcgcatgga gcagatgtac acgctgcaca cacagctgga     1020

cttcagcaag gtcaagtccc tcccactgat ctctgcctcc cggtggctgc tgaagcgcgg     1080

agagctgttc ttagtggaag aaaccggact ttttcgaaaa attgccagcc ggccaacgtg     1140

ctaccttttc ctgttcaacg atgtcctggt tgtgaccaag aagaagagcg aggagagcta     1200

catggtccag gactacgccc agatgaacca catccaggtg gagaagatag agccgtctga     1260

gctccctctg cccgggggcg gcaaccgtag ctcctccgtg ccccacccct tccaggtgac     1320

cctgcttcgc aacagcgagg gccgccagga gcagctcctg ctctcctcgg actccgcgag     1380

tgaccgggca cggtggatcg tggcgctcac acacagtgag agacagtggc agggcctctc     1440

cagcaaagga gacctgcccc aggtggagat caccaaggcc ttcttcgcga agcaagcaga     1500

cgaggtcaca ctgcagcagg cggacgtggt cctggttctg cagcaggagg atgggtggct     1560

ctatggcgag aggctccggg acggagagac gggatggttc cccgaggact ttgcccgctt     1620

catcaccagc cgtgtggccg tggagggcaa tgtccgcagg atggagcgtc tgcgggtgga     1680

gacggacgtg tagccctggc gaggccagcc ggcggcagca cagcctgtct ccaatcagca     1740

agtggtcgtg cctggctcta gagagcgtgg ggagctggtc tcaaggaccc agcatggttc     1800

cctggggctt cccaagagcc tgtggctgtg gtgccgggct ccagacactt cacggaagga     1860

agatcacatg tccccagaga ggcaccccca ggcaagctcg agggggccac accgtgtccc     1920

agggagccca gcctattccc gttggctggc tgggcccctc agctgctggg ccccacctcc     1980

ccactgcacc cagggggcaa ctccacctgg actgatgggc acaggaggca ccaatagcga     2040

ttattggggg caatgcgagg tctcctccta tgcccttcct acccctgagt gggacaagaa     2100

gggccctgag tgcccaggag tgccccacgt tctgagaagg ggccggccgg agggagggga     2160

cccggcaggg agatttcggt tttgaggttt ctaaatacat taaagttatt tcttaagaa      2219


<210> 2029
<211> 2211
<212> DNA
<213> Homo sapiens

<400> 2029
cgtgaggccc tgtggagctg acatctattg ggcacagctt cgcatgtgga gccgagaggt       60

ctctggggtc ccagggcaga atcgccgtgg gcaacacctg ccccggctga cagctgcggt      120

ttctgtgtct ctcttttgtg cagaagacgc tggggaggaa acgtgggcac aagggttcct      180

tcaaggacga cccccagctc taccaggaga tccaggagcg gggcctgaac accagccagg      240

agtctgatga cgacatcctc gatgagtcct ccagccccga gggaacccag aaggtggacg      300

ccaccattgt ggtcaagagc taccggcccg cccaggtcac ctggagccag ctcccagagg      360

tggtggaatt gggcatcctg gaccagctct ccactgagga gcggaaaagg caggaggcca      420

tgttcgagat cctcacgtcg gagttctcct accagcacag cctgagcatc ctggtggagg      480

agttcctgca gtccaaggag ctgcgggcga ccgtgaccca gatggagcac caccacctct      540

tctccaacat cctggatgtc ctgggtgcca gtcagaggtt cttcgaggac ctggagcagc      600

ggcacaaggc ccaggtgctg gtcgaggaca tcagtgacat cctggaggag cacgctgaga      660

agcacttcca cccctacatc gcctactgct ccaacgaggt ctaccaacag cgcacgctgc      720

agaagctgat aagcagcaac gccgccttcc gagaggccct gagagagatt gagaggcggc      780

cggcgtgcgg gggcctgccc atgctctcct tcctgatcct ccccatgcag cgggtgaccc      840

ggctgcccct cctgatggat acgctctgcc tcaagaccca gggccactcc gaaaggtaca      900

aggctgccag ccgtgcactg aaggccatca gcaagctggt gaggcagtgc aacgaggggg      960

cccacaggat ggagcgcatg gagcagatgt acacgctgca cacacagctg gacttcagca     1020

aggtcaagtc cctcccactg atctctgcct cccggtggct gctgaagcgc ggagagctgt     1080

tcttagtgga agaaaccgga ctttttcgaa aaattgccag ccggccaacg tgctaccttt     1140

tcctgttcaa cgatgtcctg gttgtgacca agaagaagag cgaggagagc tacatggtcc     1200

aggactacgc ccagatgaac cacatccagg tggagaagat agagccgtct gagctccctc     1260

tgcccggggg cggcaaccgt agctcctccg tgccccaccc cttccaggtg accctgcttc     1320

gcaacagcga gggccgccag gagcagctcc tgctctcctc ggactccgcg agtgaccggg     1380

cacggtggat cgtggcgctc acacacagtg agagacagtg gcagggcctc tccagcaaag     1440

gagacctgcc ccaggtggag atcaccaagg ccttcttcgc gaagcaagca gacgaggtca     1500

cactgcagca ggcggacgtg gtcctggttc tgcagcagga ggatgggtgg ctctatggcg     1560

agaggctccg ggacggagag acgggatggt tccccgagga ctttgcccgc ttcatcacca     1620

gccgtgtggc cgtggagggc aatgtccgca ggatggagcg tctgcgggtg gagacggacg     1680

tgtagccctg gcgaggccag ccggcggcag cacagcctgt ctccaatcag caagtggtcg     1740

tgcctggctc tagagagcgt ggggagctgg tctcaaggac ccagcatggt tccctggggc     1800

ttcccaagag cctgtggctg tggtgccggg ctccagacac ttcacggaag gaagatcaca     1860

tgtccccaga gaggcacccc caggcaagct cgagggggcc acaccgtgtc ccagggagcc     1920

cagcctattc ccgttggctg gctgggcccc tcagctgctg ggccccacct ccccactgca     1980

cccagggggc aactccacct ggactgatgg gcacaggagg caccaatagc gattattggg     2040

ggcaatgcga ggtctcctcc tatgcccttc ctacccctga gtgggacaag aagggccctg     2100

agtgcccagg agtgccccac gttctgagaa ggggccggcc ggagggaggg gacccggcag     2160

ggagatttcg gttttgaggt ttctaaatac attaaagtta tttcttaaga a              2211


<210> 2030
<211> 3061
<212> DNA
<213> Homo sapiens

<400> 2030
gaaggcgcag gcaccgggcg gcggcggctc ggcgggaatc gagaggcgcg atccagtccg       60

ggcgatcacg tgggctccag ccggcccagg tggggctgtg acctgtgacg caggcggcgc      120

cgccacaggt gcccgggacg cgccccgccc cctccccggc cctccccgcc cgggccctcg      180

gacccggagc agccccgccc gcccagcgcc cacctgcggg gccgcagccg ccgccctcca      240

gccagaccgc gcaggaagcg gaggaggcgc cccgggccgg accgcgctgc cgcaggagcg      300

aagcggctgc aggacaggac aggacccggc gctggaagct gcaccgccag cgcgccgccc      360

ctccgtccct ccgccccgcg gcgcaggacc ccacagccgc ccagcatggc ccagcggcac      420

tcagacagct ccttggagga gaagctcctg ggacaccgct tccactcgga gctccggctc      480

gatgccgggg ggaacccagc ctccgggctc ccaatggtcc gtggctcccc gcgtgttaga      540

gacgatgccg ccttccagcc ccaggtcccg gcacccccac agcctcggcc cccggggcac      600

gaggagccat ggcccatcgt cctgagcaca gagagcccgg cggccctcaa gctgggcacc      660

caacagctga tccctaagag cctggctgtg gccagcaagg caaagacccc agcccgccac      720

cagagcttcg gggcggctgt acttagcagg gaggccgccc ggcgggaccc taagctcctc      780

ccagccccca gcttctccct ggatgacatg gacgtggaca aggaccccgg gggcatgctg      840

aggcggaacc tgcggaacca atcctaccgg gcggccatga agggcctggg gaagccaggt      900

ggccagggag atgccatcca gctaagccct aagctccagg ctctggctga ggaacccagc      960

cagcctcata ctcggagccc ggccaaaaac aagaagacgc tggggaggaa acgtgggcac     1020

aagggttcct tcaaggacga cccccagctc taccaggaga tccaggagcg gggcctgaac     1080

accagccagg agtctgatga cgacatcctc gatgagtcct ccagccccga gggaacccag     1140

aaggtggacg ccaccattgt ggtcaagagc taccggcccg cccaggtcac ctggagccag     1200

ctcccagagg tggtggaatt gggcatcctg gaccagctct ccactgagga gcggaaaagg     1260

caggaggcca tgttcgagat cctcacgtcg gagttctcct accagcacag cctgagcatc     1320

ctggtggagg agttcctgca gtccaaggag ctgcgggcga ccgtgaccca gatggagcac     1380

caccacctct tctccaacat cctggatgtc ctgggtgcca gtcagaggtt cttcgaggac     1440

ctggagcagc ggcacaaggc ccaggtgctg gtcgaggaca tcagtgacat cctggaggag     1500

cacgctgaga agcacttcca cccctacatc gcctactgct ccaacgaggt ctaccaacag     1560

cgcacgctgc agaagctgat aagcagcaac gccgccttcc gagaggccct gagagagatt     1620

gagaggcggc cggcgtgcgg gggcctgccc atgctctcct tcctgatcct ccccatgcag     1680

cgggtgaccc ggctgcccct cctgatggat acgctctgcc tcaagaccca gggccactcc     1740

gaaaggtaca aggctgccag ccgtgcactg aaggccatca gcaagctggt gaggcagtgc     1800

aacgaggggg cccacaggat ggagcgcatg gagcagatgt acacgctgca cacacagctg     1860

gacttcagca aggtcaagtc cctcccactg atctctgcct cccggtggct gctgaagcgc     1920

ggagagctgt tcttagtgga agaaaccgga ctttttcgaa aaattgccag ccggccaacg     1980

tgctaccttt tcctgttcaa cgatgtcctg gttgtgacca agaagaagag cgaggagagc     2040

tacatggtcc aggactacgc ccagatgaac cacatccagg tggagaagat agagccgtct     2100

gagctccctc tgcccggggg cggcaaccgt agctcctccg tgccccaccc cttccaggtg     2160

accctgcttc gcaacagcga gggccgccag gagcagctcc tgctctcctc ggactccgcg     2220

agtgaccggg cacggtggat cgtggcgctc acacacagtg agagacagtg gcagggcctc     2280

tccagcaaag gagacctgcc ccaggtggag atcaccaagg ccttcttcgc gaagcaagca     2340

gacgaggtca cactgcagca ggcggacgtg gtcctggttc tgcagcagga ggatgggtgg     2400

ctctatggcg agaggctccg ggacggagag acgggatggt tccccgagga ctttgcccgc     2460

ttcatcacca gccgtgtggc cgtggagggc aatgtccgca ggatggagcg tctgcgggtg     2520

gagacggacg tgtagccctg gcgaggccag ccggcggcag cacagcctgt ctccaatcag     2580

caagtggtcg tgcctggctc tagagagcgt ggggagctgg tctcaaggac ccagcatggt     2640

tccctggggc ttcccaagag cctgtggctg tggtgccggg ctccagacac ttcacggaag     2700

gaagatcaca tgtccccaga gaggcacccc caggcaagct cgagggggcc acaccgtgtc     2760

ccagggagcc cagcctattc ccgttggctg gctgggcccc tcagctgctg ggccccacct     2820

ccccactgca cccagggggc aactccacct ggactgatgg gcacaggagg caccaatagc     2880

gattattggg ggcaatgcga ggtctcctcc tatgcccttc ctacccctga gtgggacaag     2940

aagggccctg agtgcccagg agtgccccac gttctgagaa ggggccggcc ggagggaggg     3000

gacccggcag ggagatttcg gttttgaggt ttctaaatac attaaagtta tttcttaaga     3060

a                                                                     3061


<210> 2031
<211> 1586
<212> DNA
<213> Homo sapiens

<400> 2031
gccctcgcgc tgtcgccgcc acagtctgcg acgggacccg gcgtgcccat gtgtcaggtg       60

ggcgaggact acggggagcc ggcgcctgag gagccgcccc cggcgccgcg gcccagccgt      120

gagcagaagt gtgtgaagtg caaggaagcg cagcccgttg tggtgatacg agccggagat      180

gccttctgca ggtgctcttg gcgtggtctg gggggccttc gtccagctcc atggtctggc      240

aggttcttga gggcctgagc caagattctg ccaaaagact gcgctttgtg gcaggagtca      300

tctttgttga cgagggagca gcctgtggcc agagcctaga ggagagatca aagaccctgg      360

ccgaagtgaa gcccattctg caagcaactg ggttcccatg gcatgtggtg gccttagagg      420

aggtgttcag cctgccaccg tcggtgcttt ggtgctctgc ccaggagctg gtgggatccg      480

agggggccta caaggcggcc gtggacagct tcctccagca gcagcatgtg ctgggggccg      540

ggggtggtcc tggcccgact caaggggagg aacagccacc ccagcccccg ctggaccccc      600

agaacctggc aagaccgcct gcccctgccc agactgaggc tctttcccaa ctgttctgct      660

cagtgaggac actgactgcc aaggaggagc ttctgcagac cctgcggacc cacctgatcc      720

tccacatggc ccgagcccac ggctactcca aggtcatgac tggggacagc tgcacacgct      780

tggctatcaa gctcatgacc aacctggcgc tgggtcgagg ggccttcctg gcctgggata      840

cgggcttctc ggatgagcgg cacggggacg tggtggtggt gcggcccatg cgggaccaca      900

ccctgaagga ggtcgctttc tacaaccgcc tgttctccgt tccttctgtc ttcacaccag      960

ccgtcgacac caaggcccct gaaaaggcca gcatccaccg gctgatggag gccttcatcc     1020

tcaggctgca gacccagttc ccctccactg tcagcactgt gtacaggaca agtgagaagc     1080

tggtgaaggg cccccgggat ggccctgctg ctggcgactc cggcccccgc tgcctcctct     1140

gcatgtgtgc cctggacgtc gacgccgctg acagtgccac ggcttttggg gctcagacct     1200

cctcgcgtct ctcccagatg cagtcaccca tccccctgac tgagacccgg acacccccgg     1260

ggccctgctg ttctccaggg gtgggctggg cccagcgctg tggccagggg gcctgcagga     1320

gggaggaccc ccaagcctgc attgaggagc agctgtgcta cagctgccgc gtgaacatga     1380

aggacttgcc ctcactggac cccctgccgc cgtacatcct ggctgaggcc cagctccgca     1440

cacagagggc ctggggcttg caggagatcc gggactgtct gattgaggac agtgacgacg     1500

aggcgggcca gagctgagcg tgaggacgtg cttgccggga cagcaggcag tggccacctg     1560

gtacaccaca ctggagccgg aaggca                                          1586


<210> 2032
<211> 1814
<212> DNA
<213> Homo sapiens

<400> 2032
gtggagctgg ggtcactgcg cggtgggacc atggcctcgg agaagccgct ggcggcagtc       60

acttgtacag cgccggtcaa catcgcggtc atcaagtact ggggcaagcg cgatgaagag      120

ctggttctgc ccatcaactc ctccctgagc gtcactctgc accaggacca gttaaaaacc      180

accacaacag ccgtcatcag caaggacttc accgaggacc ggatttggct gaatggccgg      240

gaggaggatg tggggcagcc gcggctgcag gcctgcctgc gggagatccg ctgcctggcc      300

cggaagcgga ggaactcacg ggatggggac ccgctgccct ccagcctcag ctgcaaggtg      360

cacgtggcat cggtgaacaa cttccccacg gctgcgggcc tggcctcctc agcggcgggc      420

tatgcctgcc tagcctacac cctggcccgt gtctacggcg tggagagtga cctctcagaa      480

gtggctcgcc ggggctcagg cagcgcctgc cggagcctgt atgggggctt tgtggagtgg      540

cagatgggag agcaggccga cgggaaggac agcatcgctc ggcaagtggc ccccgagtca      600

cactggcctg aactccgcgt gctcatcctt gtggtgagcg ctgagaagaa gctgacaggc      660

agtaccgtgg gcatgcgggc cagtgtggag accagccccc tgcttcggtt ccgggccgag      720

tccgtggtgc ccgcgcatgg cggagatggc ccgctgcatc cgggagcgag acttccccag      780

cttcgcccag ctgaccatga aggacagcaa ccagttccac gccacctgcc tcgacacctt      840

cccccatctc ttacctcaat gccatctcct ggcgcatcat ccacctggtg caccgcttca      900

acgcccacca cggggacacc aaggtggcgt acacctttga cgcgggcccc aatgccgtga      960

tcttcaccct ggacgacact gtggctgagt ttgtggctgc tgtgtggcac ggctttcccc     1020

caggctcgaa tggagacacg tttctgaagg ggctgcaggt gaggccggcc cctctctcag     1080

ctgagcttca ggctgcgctg gccatggagc cgacccccgg tggggtcaaa tacatcattg     1140

tcactcaggt ggggccaggg cctcaaatcc tggatgaccc ctgcgcccac ctcctgggtc     1200

ctgacggcct gccgaagcca gctgcctgac tgcctcagca gggaccgcat gccgcttgga     1260

gaaggggtgg cctcgccgga gctagggagc ggatgtggtg ggctggccgg actcctggga     1320

catgtgggtg gtggcttgac cccgggccca tgggcagctt gctgtggggc agtgcaggga     1380

gtcctgcggc cgcccaggtg tcaggagagg tccccgccga gtgcttcagc tgccctaagc     1440

tgcaccagcg ctttgccaag atgggatggg gagggggtat gagaactggc agagcctcgg     1500

tgcagcaggg ctgaagggct ttctcacccc agctctggct atgcccagtt ctctgagaaa     1560

ggagctcagt ggggaggtgg tccctccagc ggaccaggga aggggtcacc gtgctgggag     1620

cagcctcctt gggcctcagg aaaccaccaa gtgcctcgga tggtggctgc ccacggcgct     1680

tctgctgaga ccctgccccc ggcccaggtg tctcggaggg tggctgccca cggcctgggt     1740

gtggctggaa tggtggcagg agtgggcacc agtgcggccc cggtggccat ggggaataaa     1800

ccagcattgc tgcc                                                       1814


<210> 2033
<211> 2709
<212> DNA
<213> Homo sapiens

<400> 2033
gggatccagg agcgaggagc cgggagcggg gaacagggag tcggggagcc gggaaccagg       60

gctggcagcg gccgccatga gcacggtgga ccttgctcgc gtgggcgcgt gcatcctgaa      120

gcatgcggtg accggggagg ccgtggagct gcggagcctg tggcgggagc acgcgtgcgt      180

ggtggccggg ctgcggcgct tcgggtgcgt ggtgtgccgc tggatcgccc aggacctcag      240

cagccttgct gggctcctgg accaacacgg cgtgcgcctg gtgggcgtag ggcccgaggc      300

cctgggtctg caggagttcc tggacggcga ctacttcgcg ggagagctct acctggatga      360

gagcaagcag ctttacaagg agctaggctt caagcggtac aacagcctga gcatcctccc      420

agcagctctg gggaagcccg tgcgtgatgt ggctgccaag gccaaggctg ttggcatcca      480

ggggaacttg tctggggacc tgctgcagag cggagggctg ctggtggtca gcaaaggtgg      540

tgataaagtg ctcctgcatt tcgtccagaa gtccccaggc gactacgtcc ccaaggagca      600

catcctgcag gtcctgggca tctctgcgga ggtctgtgcc agcgacccgc ctcagtgtga      660

cagagaggtg tgagggaggc gaaggccctg gcctccgagg atctgggtgg cgtctgctgc      720

cctaggtgtg ctggaagtcc acttggaaga actgttccgg aggcgctggg tcgggatgcc      780

gaacctctcc tgatccgccg gcagcaacga gccattaaaa ctgcagttcc tgaccacgca      840

ctgcttcgca ggctccgagc cctgcatcct ccacagcccc cgccttgctc actgttgggc      900

cctcagggcg ggcagggtgg ctgtgagtcc caggtgtcat cttcctgctc tgcgactttc      960

tctggagacc ttgggccttt ggcctgtggg gcactgggga tggtaacctc actgccccgt     1020

cactcccttc aaaggcgaca gacccaagcc cacgtcagga gaggagcgtg gggtcagctc     1080

cagcagggtc ggggtcagtg cctgtgtctg gtgggggcca ctcaggagag ttgggttttc     1140

agggcagaga tgggcttgat tccacctggt ggggtgggtg gaccctggag actctcaggt     1200

gatgggccag cctgccccaa ggctctttac tgatgtcaga atcattgttt gcacctgctg     1260

ggtatggcct ttggggcggc cggcccggga gggtcttagt ctaattaggt gtgtccagct     1320

tcttggccac ctttccctgg ggaccctaac aggcccagag cagagcccct tacctcccag     1380

gtcagactac ctgctcaggc cctcccctcc catgcaggcc gatgacaact gcagccctct     1440

ctgcactccc tagtccagac ctggggacca ctgtgggttc ctgtgggtct cccggctccc     1500

ttcctgcccc caatgccacc cttgcagtgg ccatttaaaa atgcatagca ggtgacccac     1560

tgcgtccctt tgcgttcagc ccctcctctg gctttcagtt acaccaagct aaaatttcag     1620

gttcccagct gcagctctct gggtcccccg gtgccccagt ggggctcccc gcatctgaat     1680

gtgtggtccc tgggggtggg cacttggggg catcctggtc actgctggcc ctagcattgg     1740

accctaggag acctgactgg aactggctcc ctccccatca gctcccagct gtcactctct     1800

cccacccccg ggcagctgtt ttgcccaaga ccactgctac ctgtttaccc accctggtcc     1860

ctcccagaca agcaaggcct ctgatttctt tgaagcattt acttagctca agtctgaagc     1920

tgtagatact ggaagacaat gcaccttgga gggtgggcag gacacagttg attgtctcta     1980

cagagctgtg acgggggcac tgagccccgc gggtgtctgt ggagggggct ccggtccagg     2040

tactgcactg gacactgctc atccctgggt gtcaggcagg tggctgcacc ctaggccagg     2100

cgcagaggcc tggcaggcag gcttggcatg gttggccggg gcgggacgta cactgggtcg     2160

ccgctagctg caccttcgca cagatgcctc cgagcagcgg gtgggcgtgg gccgcacagc     2220

gcggcagggc cttggctacc acacgcggca tcgctccttg gggtgcatgg gggtgccccg     2280

ggcacagtgg aacgtgtctg cgaaggcggc caggttctgc agcgacccca gtaccctgtg     2340

ggtgggtggg tgtgacagca ggagcattgc catcttggac aaacatggcc attttaagtt     2400

ctccgtgatt aaaaaccagc ccaaaacatc agcctaatgg ctcatgtcag tatgagcaga     2460

aacatttcaa ccatgagata aacccccatc tgaccagaaa catgccaatc ctgagaataa     2520

cctcccctcc agccagagat attccaactc tgcaataaaa ctctccttca cacagaaaca     2580

ttcgcagcct gcggtaggct cccccttcct aaacccttaa atgcccttag tctgtaagag     2640

aatgtccctg accgaaatcg gccagaagcc cctctcaggt ttattcccaa aataaacctg     2700

tctctgttg                                                             2709


<210> 2034
<211> 2689
<212> DNA
<213> Homo sapiens

<400> 2034
gagccgggag cggggatcca ggagcgagga gccgggagcg gggaacaggg agtcggggag       60

ccgggaacca gggctggcag cggccgccat gagcacggtg gaccttgctc gcgtgggcgc      120

gtgcatcctg aagcatgcgg tgaccgggga ggccgtggag ctgcggagcc tgtggcggga      180

gcacgcgtgc gtggtggccg ggctgcggcg cttcgggtgc gtggtgtgcc gctggatcgc      240

ccaggacctc agcagccttg ctgggctcct ggaccaacac ggcgtgcgcc tggtgggcgt      300

agggcccgag gccctgggtc tgcaggagtt cctggacggc gactacttcg cgggagagct      360

ctacctggat gagagcaagc agctttacaa ggagctaggc ttcaagcggt acaacagcct      420

gagcatcctc ccagcagctc tggggaagcc cgtgcgtgat gtggctgcca aggccaaggc      480

tgttggcatc caggggaact tgtctgggga cctgctgcag agcggagggc tgctggtggt      540

cagcaaagaa gtccccaggc gactacgtcc ccaaggagca catcctgcag gtcctgggca      600

tctctgcgga ggtctgtgcc agcgacccgc ctcagtgtga cagagaggtg tgagggaggc      660

gaaggccctg gcctccgagg atctgggtgg cgtctgctgc cctaggtgtg ctggaagtcc      720

acttggaaga actgttccgg aggcgctggg tcgggatgcc gaacctctcc tgatccgccg      780

gcagcaacga gccattaaaa ctgcagttcc tgaccacgca ctgcttcgca ggctccgagc      840

cctgcatcct ccacagcccc cgccttgctc actgttgggc cctcagggcg ggcagggtgg      900

ctgtgagtcc caggtgtcat cttcctgctc tgcgactttc tctggagacc ttgggccttt      960

ggcctgtggg gcactgggga tggtaacctc actgccccgt cactcccttc aaaggcgaca     1020

gacccaagcc cacgtcagga gaggagcgtg gggtcagctc cagcagggtc ggggtcagtg     1080

cctgtgtctg gtgggggcca ctcaggagag ttgggttttc agggcagaga tgggcttgat     1140

tccacctggt ggggtgggtg gaccctggag actctcaggt gatgggccag cctgccccaa     1200

ggctctttac tgatgtcaga atcattgttt gcacctgctg ggtatggcct ttggggcggc     1260

cggcccggga gggtcttagt ctaattaggt gtgtccagct tcttggccac ctttccctgg     1320

ggaccctaac aggcccagag cagagcccct tacctcccag gtcagactac ctgctcaggc     1380

cctcccctcc catgcaggcc gatgacaact gcagccctct ctgcactccc tagtccagac     1440

ctggggacca ctgtgggttc ctgtgggtct cccggctccc ttcctgcccc caatgccacc     1500

cttgcagtgg ccatttaaaa atgcatagca ggtgacccac tgcgtccctt tgcgttcagc     1560

ccctcctctg gctttcagtt acaccaagct aaaatttcag gttcccagct gcagctctct     1620

gggtcccccg gtgccccagt ggggctcccc gcatctgaat gtgtggtccc tgggggtggg     1680

cacttggggg catcctggtc actgctggcc ctagcattgg accctaggag acctgactgg     1740

aactggctcc ctccccatca gctcccagct gtcactctct cccacccccg ggcagctgtt     1800

ttgcccaaga ccactgctac ctgtttaccc accctggtcc ctcccagaca agcaaggcct     1860

ctgatttctt tgaagcattt acttagctca agtctgaagc tgtagatact ggaagacaat     1920

gcaccttgga gggtgggcag gacacagttg attgtctcta cagagctgtg acgggggcac     1980

tgagccccgc gggtgtctgt ggagggggct ccggtccagg tactgcactg gacactgctc     2040

atccctgggt gtcaggcagg tggctgcacc ctaggccagg cgcagaggcc tggcaggcag     2100

gcttggcatg gttggccggg gcgggacgta cactgggtcg ccgctagctg caccttcgca     2160

cagatgcctc cgagcagcgg gtgggcgtgg gccgcacagc gcggcagggc cttggctacc     2220

acacgcggca tcgctccttg gggtgcatgg gggtgccccg ggcacagtgg aacgtgtctg     2280

cgaaggcggc caggttctgc agcgacccca gtaccctgtg ggtgggtggg tgtgacagca     2340

ggagcattgc catcttggac aaacatggcc attttaagtt ctccgtgatt aaaaaccagc     2400

ccaaaacatc agcctaatgg ctcatgtcag tatgagcaga aacatttcaa ccatgagata     2460

aacccccatc tgaccagaaa catgccaatc ctgagaataa cctcccctcc agccagagat     2520

attccaactc tgcaataaaa ctctccttca cacagaaaca ttcgcagcct gcggtaggct     2580

cccccttcct aaacccttaa atgcccttag tctgtaagag aatgtccctg accgaaatcg     2640

gccagaagcc cctctcaggt ttattcccaa aataaacctg tctctgttg                 2689


<210> 2035
<211> 5432
<212> DNA
<213> Homo sapiens

<400> 2035
agactgaggc tggctggctg gaggttgaca caggagtgct caggggagca gcatcacaag       60

agggcagatc gaaagcatcg tccttgctga aaaacagatg gcagaggtgg aagcggtaca      120

gctgaaggag gaaggaaacc ggcatttcca gctccaggac tacaaggccg ccacaaatag      180

ctacagccag gccctgaagc tgaccaagga caaggccctg ctggccacgc tttatcggaa      240

ccgggcagcc tgtggcctga aaacggagag ctacgtccag gcagcttcag atgcctccag      300

agccatcgac atcaactcct cggacatcaa ggctctgtat cggcgatgcc aggcactgga      360

gcacctgggg aagctggacc aggccttcaa agacgtgcag cgttgtgcca ccctcgagcc      420

acggaaccag aacttccagg agatgctgag gagactcaac accagcattc aggagaagct      480

ccgagtgcag ttctccacag actcgagggt acagaagatg tttgagatcc tcttggatga      540

aaacagtgag gctgataagc gggaaaaggc tgccaacaat ctcattgtcc taggccgtga      600

ggaagcaggg gctgagaaga tcttccagaa caatggagta gccttgctac tgcagcttct      660

ggacactaag aagcctgagc tggtgctggc tgcagtgcgg accctgtcgg gcatgtgcag      720

cggccaccaa gccagagcca cagtgattct gcatgcagtg cggatagacc gaatctgtag      780

cctcatggcc gtggagaatg aggagatgtc tctggctgtc tgcaacctgc tccaagccat      840

cattgactcc ttgtctgggg aggacaagcg ggagcatcga gggaaggagg aggccctggt      900

tctagacacc aagaaggacc tgaagcagat caccagccac ctgctggaca tgctagtcag      960

caagaaggtg tctggccagg gcagggatca ggcgctgaac ctgctcaata agaatgttcc     1020

caggaaggac cttgccattc atgacaactc acgtaccatc tatgtggtgg ataatggtct     1080

gaggaagatc ctgaaggttg tggggcaggt tccagatctg ccatcctgcc tgcccctgac     1140

tgacaacacc cgcatgctgg cctctatcct catcaacaag ctctatgatg acctgcgctg     1200

tgacccggag cgcgatcact tccgcaagat ctgtgaggaa tatatcacgg gcaagtttga     1260

cccccaggac atggacaaga acttgaatgc catccagaca gtgtcaggga tcctgcaggg     1320

cccctttgac ctgggcaacc agctgctggg actgaaaggt gtgatggaga tgatggtggc     1380

actatgtggc tcagagcgcg agacggacca gctggtggcc gtggaggccc tcatccatgc     1440

ctccacgaag ctcagccgcg ccaccttcat catcaccaat ggagtgtcac tgctcaaaca     1500

gatctacaag accaccaaaa atgagaagat caagatccgc acactggtga ccagtgacaa     1560

gaccatcctg tactcggtgg ccaccaccct ggtgaactgc accaacagct acgatgtcaa     1620

ggaggtcatc ccagagcttg tccagctcgc caagttctcc aagcagcatg tgcccgagga     1680

acaccccaag gacaagaagg actttataga catgcgggtg aagcggcttc tgaaggcggg     1740

tgtcatctct gccctggctt gcatggtgaa agcagatagt gccatcctca ctgaccagac     1800

caaggagctg ctggccaggg tattcctggc actgtgtgac aacccaaagg accgaggcac     1860

cattgtggct caaggtggtg gcaaggccct gattcccctg gctttggagg gcacagatgt     1920

gggcaaggtg aaggcagccc acgctctagc aaagatcgct gctgtctcca atccggacat     1980

tgcttttcct ggggagcggg tgtatgaggt ggtgcggccc cttgtaagac tcttggacac     2040

acagagggat gggcttcaga actatgaggc tctcctaggc ctcaccaacc tgtctgggcg     2100

gagtgacaaa ctccggcaga agatctttaa ggagagggcc ttgccagaca tcgagaacta     2160

catgtttgag aatcatgatc agctgcggca ggcggccacc gagtgcatgt gcaacatggt     2220

gctccacaag gaggtacagg aaaggttctt ggctgacggg aatgaccggc tgaagctggt     2280

ggtgctgctc tgcggggagg atgatgataa ggtgcagaat gcggctgcag gggctctggc     2340

catgctgaca gcagcacaca agaaactgtg cctcaagatg actcaagtga caacccagtg     2400

gttggagatc ctccagcggc tttgcctgca cgaccagctg tctgtccaac accggggcct     2460

ggtcattgcc tacaacctac tggcagccga tgctgagctg gccaagaagc tggtggagag     2520

tgagctgctg gagatcctga ctgtggtggg caaacaggag ccagatgaga agaaggcaga     2580

agtggttcag acagcccgag aatgtctcat caagtgcatg gattatggtt tcattaaacc     2640

agtgtcttag acagcgaccc tcagggatgc tgggagtggt cctgtactgt gcagagtcct     2700

gggttggttg ggttctcctg aagagtcagg tcatctaggg atcatagcag tgacaatgaa     2760

gtctcaatat aaaggaaaga cttgattgtt ctctgagttg tgagtcttct cctttgtcct     2820

gacagagttt ggatgtttca ctctctctct tgcttcctgt ctccttatat ttgtcatgtt     2880

tcagaaattc ccagaataat tttcacccat gattagaaat aggttggatc attctttctg     2940

tacccattct gaaggccagg ataataggtt gaagttcttt atattttgga aaatggattt     3000

tgtggtaagg taggaactaa cgggtgtgtg catataaagg ttaatgctgt tgtatttgga     3060

tgctgatctg tgctgttttc atgacctctc tcccacacta tttgaatcag tctgttcaga     3120

actgtgtgtt tcacctgcag tgctctgtcc cagtcccatg cccattccca tcacttcact     3180

gtgatggaaa tagagtttat gttcaacagt ggggcatgac ctctgcaatt tgcttgggaa     3240

agtcttccaa gcaagatgga catgatgaat acaaataaga tctactcaaa gtacttcaaa     3300

caaaaaataa ataattcatt ggctcatgta tcttggccac ccagggaagg tctgacattg     3360

ttagttagat ccagagtttc aaatgtcatc accatggatg tgtctttttc tctctctcat     3420

ttcccctccc catatcttgt cttttattta ttataggttt gtctcattcc ctggcaggct     3480

ctctccctgt gataggaaag agagtcccca gcagccccag ggtgacatag ttgttatagt     3540

tcattatgga atagaagaga gaagagcatt ctcaataacc cggcaaagtt cccagggatg     3600

actctgatat gtctatgtct caggtcacat ttccatctat gaaccaatca tattcagagg     3660

tggaatgcta attggccagg cctgggtcat atatacaagt ctagggaaga aatgagcttc     3720

atccctgtcc aattgacatg gactgattag gggtattaat ggaagaggtg tgccaccaca     3780

aaagaatgta ccctgggcag atcaaagaac atattctgta tgtcaggctt ggccacaaaa     3840

gaatgacaca agtaatatgc tgtagatcag aacctctctg ctaatattgc ctttttagca     3900

tggttaagat agctaagatc tagtactgtc actccagtat gtcccaattc tacctacgtt     3960

tattgaaggg tcaacagttc tgatctcagc attgggtaaa gggtgggaca ttcagattta     4020

cggtccttga taaaaacaat ttacaacgtt ccgttgtgta ataaatgtaa gtgtacatat     4080

gcctgggaca tcagctggaa aagggacaga ctatcagaga gttgcactgt tgcggtatgg     4140

gccaaatcca acataatacc cgctgtacct ctagagaact aaaaccttaa tttctcagat     4200

cttttctgca ctaatggtct ttacatacag cctacatttt aactaactct tgcatgggct     4260

tgtttcacag caggaaacta tattcatcat atccttatta tgatagagaa tgacaacatt     4320

caaaagggtg tggtgcttct gaaaatatac acaataaatg gcatgatttg acctctgtca     4380

aattcttctt tcctgctttc ctcatatgtg ggcttgagtg ggtgtattta gctcctttaa     4440

aggaaactct ttcacaggca gggccacact cttactcgtt ttgatctcat gaggttacat     4500

ctgccagtgg cgttcagggc cagttagata aagttcatct tgtttggatt ggagagactt     4560

tttttttttt tttttttgag acagggtctt gctctgtaac ctaggctcaa gtgcagtgca     4620

gtggtgcagt catggctcac cgcagccttg gtctcctggg ctcaagtgat ctttctactt     4680

cagcctcctc aatagctggg actacaggca cacaccacca cccccaggta attaaaaaat     4740

ttttttttgt agagacaggg tctcactatg ttgcccagtc tgggagacca cattctttaa     4800

catgaatatt ttgtaaatag tccaagaaga tctagaggaa agctgaattc cttcatctga     4860

tttttgccac tgggctgcct cccattgtct ggctaagtct tcatgggagg cctttaagaa     4920

aagctgtgac aaataccttt gtttcccact gcctaggtta cataagtagt tggcttttcc     4980

agcctagact cttatattgt tgcttgtaag agggcccttc tttgcagatt tctttttttt     5040

ttcatctatg ctttcaaata ggcagatgct agcctgagat catctcttta ttgaggtagt     5100

ttgcccaaaa acagcaagga acagccaata cctgccaact ttctaggttt ttccaaccaa     5160

ttctcttaca gaaaatctat aaatatctta gaggtatgtt tcttagtttc ccaacatata     5220

atgggaaaat tcatcattta tattattact tttaactgaa gtatgttgtt atcagagaac     5280

ttggtctgtg tcatattaat cctttgccat ttgagaagca tacagtttta aagtttatat     5340

ctccaaaagg atattttgta aaaatttaac ccctttgact cttagtcttc tcatttgtga     5400

aaggtaaata ataaagaatt tctgttccta gt                                   5432


<210> 2036
<211> 1889
<212> DNA
<213> Homo sapiens

<400> 2036
cggacctttt ccttctggag tttccccggc gggttcacag tccagccact gaccgcagca       60

gcgcccttgc gtagcagccg cttgcagcga gaacactgaa ttgccaacga gcaggagagt      120

ctcaaggcgc aagaggaggc cagggctcga cccacagagc accctcagcc atcgcgagtt      180

tccgggcgcc aaagccagga gaagccgccc atcccgcagg gccggtctgc cagcgagacg      240

agagttggcg agggcggagg agtgccggga atcccgccac accggctata gccaggcccc      300

cagcgcgggc cttggagagc gcgtgaaggc gggcatcccc ttgacccggc cgaccatccc      360

cgtgcccctg cgtccctgcg ctccaacgtc cgcgcggcca ccatgatgca aatctgcgac      420

acctacaacc agaagcactc gctctttaac gccatgaatc gcttcattgg cgccgtgaac      480

aacatggacc agacggtgat ggtgcccagc ttgctgcgcg acgtgcccct ggctgacccc      540

gggttagaca acgatgttgg cgtggaggta ggcggcagtg gcggctgcct ggaggagcgc      600

acgcccccag tccccgactc gggaagcgcc aatggcagct ttttcgcgcc ctctcgggac      660

atgtacagcc actacgtgct tctcaagtcc atccgcaacg acatcgagtg gggggtcctg      720

caccagccgc ctccaccggc tgggagcgag gagggcagtg cctggaagtc caaggacatc      780

ctggtggacc tgggccactt ggagggtgcg gacgccggcg aagaagacct ggaacagcag      840

ttccactacc acctgcgcgg gctgcacact gtgctctcga aactcacgcg caaagccaac      900

atcctcacta acagatacaa gcaggagatc ggcttcggca attggggcca ctgaggcgtg      960

gcgcccgtgg ctgcccagca ccttcttcga cccatctcac cctctctcat tcctcaaagc     1020

tttttttttt tttcctggct ggggggcggg aagggcagac tgcaaactgg ggggctgcgt     1080

acgtgcagga ggcgcggtgg ggctgcgtgg aggagggggc cacgtgtgag agagaagaaa     1140

atggtggccg gagatgggag ggcccaagga acctcctggg agggggcctg cattctatgt     1200

tggtgggaat gggactgggc tgacgccctg cattcagcct gtgcctttcc tggggtttct     1260

tttctgttct tttcggagga gagggcccga gaaggggcca taccagggcg cggcgctggg     1320

ttgccacact tgggaaagca gcccggagct gggtgctggg gaaggcgggg cgcgtagcct     1380

cccgccgccc tgcggttggg ccggtggagg cccaggcgtt gctaggattg catcagtttt     1440

cctgtttgca ctatttcttt ttgtaacatt ggccctgtgt gaagtatttc gaatctcctc     1500

cttgctctga aacttcagcg attccattgt gataagcgca caaacagcac tgtctgtcgg     1560

taatcggtac tactttatta atgattttct gttacactgt atagtagtcc tatggcaccc     1620

ccaccccatc cctttcgtgc cactcccgtc cccaccccca ccccagtgtg tataagctgg     1680

catttcgcca gcttgtacgt agcttgccac tcagtgaaaa taataacatt attatgagaa     1740

agtggactta accgaaatgg aaccaactga cattctatcg tgttgtacat agaatgatga     1800

agggttccac tgttgttgta tgtcttaaat ttatttaaaa ctttttttaa tccagatgta     1860

gactatattc taaaaaataa aaaagcaaa                                       1889


<210> 2037
<211> 3897
<212> DNA
<213> Homo sapiens

<400> 2037
gaaggtaaaa aaaagaggga ggtctgagaa atagaaatat cagaggaagg aaataaagga       60

gggtgagagt aaattctctt ttagcattca gattccacag attccacaaa tcacatttct      120

ttttttacca actaaggaaa aataacactt gacctaacat ttcattgcag ttagctaaag      180

gatgctagaa aaactatgtt gcagtggttt gctctaattt cttcaggaat agagaaaagt      240

gacaaaaaga tcagagaaga gaagaaagga aactatcaga aaaatacaga attggagtag      300

gatataacat atttgggttg aaggtaaaat tttatattgt aatcttaagt atcttgctac      360

ttcagtttgg tccctggaac agcagcatca gaatctgccg agggcttgtt aaaaaggcag      420

aatctcaggt cccatcccag actcactgaa tcagaatata aatactgaca agatgccccg      480

ggattcatat gcacagtaga gctggcgaag ttccattgta gcctgtgatt gttttctgca      540

acttagtatt tctgagtttt cccaaggaag aaaacccagg ccttagcttc tggcagactt      600

gtgtttctcc tttacttact agctgcatga ctcatgagca aggaaatcaa actttatgtg      660

cctgagtttc ctcatctata aaatggagac tataataatc atctcctagg cttgttttga      720

ggatgttcaa caaatgctcc tttcattcct ctatttacag acctgccgca gacaattctg      780

ctagcagcct ttgtgctatt atctgttttc taaacttagt aattgagtgt gatctggaga      840

ctaactctga aataaataag ctgattattt atttattttc tcaaaacaac agaatacgat      900

ttagcaaatt acttcttaag atattatttt acatttctat attctcctac cctgagttga      960

tgtgtgagca atatgtcact ttcataaagc caggtataca ttatggacag gtaagtaaaa     1020

aacatattat ttattctacg tttttgtcca aaaattttaa atttcaactg ttgcgcgtgt     1080

gttggtaatg taaaacaaac tcagtacagt agtattcagt acagtattta agcccctgta     1140

cttaaacata ttcctcgtac caatgaagtt acatgaaaag caaatttgtg tgagatatcg     1200

tagatggaag taaattagtc tttatgttcc ccacaaattg aaatgcattt caaaaactct     1260

gtgtgtgtat gtgtgtgtgt gacagagtgt gtgtgagaga gagacagaga gatacgcttt     1320

ggttgcctcc ataagctggc tgctatgatt aataagacca agttttctaa agaaaatgag     1380

atcataacaa aagccctctt tatgactatc ttttatcagg ggcaaaaagg aaagagacaa     1440

aacagcatga aatgatgaga ccaagtgatg aaaattcatt cacaatgatt gctttcaaga     1500

gtaatttctc ttgggtaatt cagcagcctg ttactatggc tctctggagt gatagctaat     1560

gtaaatgaag cctctaaaag tggattatcc tgacaagaat atactcagcc aataatgcaa     1620

cagaaatcca ttcaaagcat tcgggaaaaa ttcaaaagaa taaatattct tttttttttt     1680

ttaaagttaa tgacctacga tccatttctt ccctgactaa caagcagcaa gcacttaaaa     1740

atatccagcc aggatgaaat agaaacccac ctgacttgtt aatatttttg tttggtccca     1800

gggactcaga ttctaagcca aattctttga atgatcttgg caaatgtctc gaattatttt     1860

tgccaacttt tctttatctt ggaaaaaaag tttcatgaat gggtgtcaaa attgattagt     1920

tttaaaaacc tttcttgcag atacgtatgg caccctaaaa ctgtattaga aaaaaatttc     1980

atatctccag gcctttcatt gggtcaggtt ggcatttcgc tgccctttat gtgtgtgaca     2040

agtgaaaata aggaaagaaa aaaactcaag tgaagaaaat cagaatctgc gcagcagttc     2100

ctgggcgttt cagctgcttc ccacatcacc tgcctcatca agccccagca tccatctcct     2160

tgctcatctt acaccctgtg tgcatgacag gcccaccatt catttatcag agcaaaggct     2220

ctcccactat tctggttcac ccccctactt agccagatat acaagaatat ctgcacggat     2280

gacctgcctc acctgggagc tcagaggagc tcagattcca ttactatcgc accaaggaca     2340

gatctcccag caagaatgac agaaaagact aactgccccc aaaatctccc ttccaaaaca     2400

cagttctctt aattctccca agaaaccaga atgtgactgc tcacctctct aaggacctga     2460

aaacaactgg ccatttcagc tatttaaatc aactttaaaa aatccaaccg ccaaaatatt     2520

aaaccatttt ggttggaatg ataacataac taacctgctg acagctgctt ctgctaggtg     2580

caaaaatgga aaaaaaaata cttctaatca ggtcaaatca ctctaccttt gggattctaa     2640

atttactcat attctcaaag aaatatattc agtcatagtg gggaaaatag gattattcct     2700

ttagctcgat aagcaaccag aagttcttcc ttcaaatctt gacatttaat caatcagaaa     2760

ttgatttttg gaaaactgtt tcctatgaag ctatctctgc ctgaaggatt tttcttttac     2820

aatccagact atagaaggaa attcacaacc tggactttca cctccattgg tcagagtttt     2880

actgaccaat tcccacctct gccttacacc taacggaagt ttatgcctgt tttctcttca     2940

cataccccaa cagttacaaa tggttgttat tattaagcat cttttatttt gtggcctctg     3000

attacatggt cccctaaatt ttgacctaat cacaaaagat tggtaaaatt tcttaacata     3060

ttaataatat tttgtttatg tgtcaatatc ttagcatgta tcaattaaga cagaggtctt     3120

aacgttctct ttttgaaaga gaatattagg attcagagat attaagagat tctcccagga     3180

tcacagttag gtaacagagc tggattttag tccaggtctg tctacagctc taacgtatat     3240

acaccctttg tataacatgt cacgaattca gcataaaggg atcttcagtg atctaagtca     3300

ggggtcagca accttttcta aaaaggacca aatagtaata tttcaggctt tgtggaccct     3360

atggtctcta tcataactgt tcaaatcacc atgtagtgta aaaggagcca taagcaaaat     3420

ataaactaac gaatgtggct gttttatggg attttttttt aactctttat ttacaaaagc     3480

aggtggcaga tcagaactca cttatgggcc atagttctct gacccctgac ctgagaaaat     3540

cttatattta tggacaacat ttagactgtg acttgccaag taagaacaag aagctctgtc     3600

aactgaaggt caaggctgga gttctgaaag caaagagctg tctggtgtta atgataagtg     3660

aaatagttaa agttagaaga tcccagttat aagaagcaca aagaataatg accatagact     3720

cctgaacaag aatgtctgga cttctggctt aggcactctt gttgtatggt ccaggccaag     3780

ttacctaatc tctccaggcc tccattttct tatcattaaa tgaagataat aaaagtattt     3840

tcctcagaga gctgtaagaa taaactgagc taacccatgt caagcacata gaatagg        3897


<210> 2038
<211> 1495
<212> DNA
<213> Homo sapiens

<400> 2038
gagctgcggc ggtggcacct ccgggtgtgg aaggctccag tgagatggag tcgcgagtcg       60

cggacgctgg gaccggcgag accgcgcgag cagcgggcgg gagtccggca gttggctgca      120

ccactcgggg gcccgtagtc tcggcgcccc tgggagccgc ccggtggaag ctcctgcggc      180

aggttctgaa gcaaaaacac ctggatgatt gcctgcgaca tgtatctgta agaagatttg      240

aatcatttaa tctgttttca gtaacagaag gcaaagaaag ggaaactgaa gaggaggttg      300

gtgcatgggt ccaatataca agcatcttct gtcctgaata cagtatctcc ttaaggcata      360

atagtggatc cttgaatgtt gaagatgtcc ttaccagctt tgacaataca ggaaatgttt      420

gcatctggcc atctgaagag gttttggctt actactgcct caagcacaat aatatattca      480

gggcccttgc tgtgtgtgag ctagggggtg gcatgacatg cttggctggg ctcatggttg      540

ctatttctgc agatgtcaaa gaagttctgt taactgatgg gaatgaaaag gccatcagaa      600

atgtgcaaga catcatcaca aggaatcaga aggctggtgt gtttaagacc cagaaaatat      660

caagctgcgt tttacgatgg gataatgaga cagatgtctc tcaactggaa ggacattttg      720

acattgttat gtgtgctgac tgcctgtttc tggaccagta cagagccagc cttgttgatg      780

caataaagag attactccag cccaggggga aagcgatggt atttgcccca cgccgaggga      840

atactttaaa ccagttttgc aatctagctg aaaaagctgg tttctgtatc caaagacatg      900

aaaattatga tgaacacatt tcaaacttcc actccaagtt gaaaaaggaa aacccggaca      960

tatatgaaga aaaccttcat tacccgcttc tgcttatttt gaccaaacat ggatagaaga     1020

ttaagcttct caaagacgaa gaaacgtatc aagtgcatag ggaatatttt tacaaaaacg     1080

gaaatctgta aggggtataa tcgcctgcct gcgccctttg cagcatttca cgtgtgggct     1140

atggactcca cctgtcctca cccacgttat tccccagctg ccctctccag ctccctcccc     1200

gcctcttttt acactctgct tgttgctcgt cctgccctaa acctttgttt gtctttaaat     1260

gtgtataagc tgcctgtctg tgacttgaat ttgactggtg aacaaactaa atatttttcc     1320

ctgtaattga gacagaattt cttttgatga tacccatccc tccttcattt tttttttttt     1380

tttggtcttt gttctgtttt ggtggtggta gtttttaatc agtaaaccca gcaaatatca     1440

tgattctttc ctggttagaa aaataaataa agtgtatctt tttatctccc tccaa          1495


<210> 2039
<211> 3120
<212> DNA
<213> Homo sapiens

<400> 2039
atggcagtgc agctggtgcc cgactcagct ctcggcctgc tgatgatgac ggagggccgc       60

cgatgtcaag tacatcttct tgatgacagg aagctggaac tcctagtaca gcccaagctg      120

ttggccaagg agcttcttga ccttgtggct tctcacttca atctgaagga aaaggagtac      180

tttggaatag cattcacaga tgaaacggga cacttaaact ggcttcagct agatcgaaga      240

gtattggaac atgacttccc taaaaagtca ggacccgtgg ttttatactt ttgtgtcagg      300

ttctatatag aaagcatttc atacctgaag gataatgcta ccattgagct tttctttctg      360

aacgcgaagt cctgcatcta caaggagctt attgacgttg acagcgaagt ggtgtttgaa      420

ttagcttcct atattttaca ggaggcaaag ggagattttt ctagcaatga agttgtgagg      480

agtgacttga agaagctgcc agcccttccc acccaagccc tgaaggagca cccttccctg      540

gcctactgtg aagacagagt cattgagcac tacaagaaac tgaacggtca gacaagaggt      600

caagcaatcg taaactacat gagcatcgtg gagtctctcc caacctacgg ggttcactat      660

tatgcagtga aggacaagca gggcatacca tggtggctgg gcctgagcta caaagggatc      720

ttccagtatg actaccatga taaagtgaag ccaagaaaga tattccaatg gagacagttg      780

gaaaacctgt acttcagaga aaagaagttt tccgtggaag ttcatgaccc acgcagggct      840

tcagtgacaa ggaggacgtt tgggcacagc ggcattgcag tgcacacgtg gtatgcatgt      900

ccggcattga tcaagtccat ctgggctatg gccataagcc aacaccagtt ctatctggac      960

agaaagcaga gtaagtccaa aatccatgca gcacgcagcc tgagtgagat cgccatcgac     1020

ctgaccgaga cggggacgct gaagacctcg aagctggcca acatgggtag caaggggaag     1080

atcatcagcg gcagcagcgg cagcctgctg tcttcaggtt ctcaggaatc agatagctcg     1140

cagtcggcca agaaggacat gctggctgcc ttgaagtcca ggcaggaagc tctggaggaa     1200

accctgcgtc agaggctgga ggaactgaag aagctgtgtc tccgagaagc tgagctcacg     1260

ggcaagctgc cagtagaata tcccctggat ccaggggagg aaccacccat tgttcggaga     1320

agaataggaa cagccttcaa actggatgaa cagaaaatcc tgcccaaagg agaggaagct     1380

gagctggaac gcctggaacg agagtttgcc attcagtccc agattacgga ggccgcccgc     1440

cgcctagcca gtgaccccaa cgtcagcaaa aaactgaaga aacaaaggaa aacctcgtat     1500

ctgaatgcac tgaagaaact gcaggagatt gaaaatgcaa tcaatgagaa ccgcatcaag     1560

tctgggaaga aacccaccca gagggcttcg ctgatcatag acgatggaaa cattgccagt     1620

gaagacagct ccctctcaga tgcccttgtt cttgaggatg aagactctca ggttaccagc     1680

acaatatccc ccctacattc tcctcacaag ggactccctc ctcggccacc gtcgcacaac     1740

aggcctcctc ctccccagtc cctggaggga ctccgacaga tgcactatca ccgcaacgac     1800

tatgacaagt cacccatcaa gcccaaaatg tggagtgagt cctctttaga tgaaccctat     1860

gagaaggtca agaagcgctc ctctcacagc cattccagca gccacaagcg cttccccagc     1920

acaggaagct gtgcggaagc cggcggagga agcaactcct tgcagaacag ccccatccgc     1980

ggcctcccgc actggaactc ccagtccagc atgccgtcca cgccagacct gcgggtccgg     2040

agtccccact acgtccattc cacgaggtcg gtggacatca gccccacccg actgcacagc     2100

ctcgcactgc actttaggca ccggagctcc agcctggagt cccagggcaa gctcctgggc     2160

tcggaaaacg acaccgggag ccccgacttc tacaccccgc ggactcgtag cagcaacggc     2220

tcagacccca tggacgactg ctcgtcgtgc accagccact cgagctcgga gcactactac     2280

ccggcgcaga tgaacgccaa ctactccacg ctggccgagg actcgccgtc caaggcgcgc     2340

cagaggcaga ggcagcggca gcgggcggcg ggcgcactgg gctcagccag ctcgggcagc     2400

atgcccaacc tggcggcgcg cgggggtgcg gggggcgcgg ggggcgcggg gggcggtgtg     2460

tacctgcaca gccagagcca gcccagctcg cagtaccgca tcaaggagta cccgctgtac     2520

atcgagggcg gcgccacgcc cgtggtggtg cgcagcctgg agagcgacca ggagggccac     2580

tacagcgtca aggctcagtt caagacgtcc aactcctaca cggcgggcgg cctgttcaag     2640

gagagctggc gcggcggcgg cggcgacgag ggcgacacgg gccgcctgac gccgtcgcga     2700

tcgcagatcc tgcggactcc gtcgctgggc cgcgagggcg cccacgacaa gggcgcgggc     2760

cgtgccgccg tctcagacga gctgcgccag tggtaccagc gttccaccgc ctcgcacaag     2820

gagcacagcc gcctgtcgca caccagctcc acctcctcgg acagcggctc gcagtacagc     2880

acctcctccc agagcacctt cgtggcgcac agcagggtca ccaggatgcc ccagatgtgc     2940

aaggccacgt cagctgcctt acctcaaagc cagagaagct cgacaccgtc aagtgaaatt     3000

ggagccaccc ccccaagcag cccccaccac atcctaacct ggcagactgg agaagcaaca     3060

gaaaactcac ccattctgga tgggtctgag tctccacctc accaaagtac tgatgaatag     3120


<210> 2040
<211> 2432
<212> DNA
<213> Homo sapiens

<400> 2040
tgtaaccagc gtgcagtttt ctccacatgg aaacttattg gcgtctgcct cacgagacag       60

aaccgtgaga ctctggattc ctgataagag aggaaaattc tcagaattta aagctcatac      120

agctccagtt cgaagtgtag acttttcagc tgatggccag tttctagcta cagcttctga      180

agacaaatcc ataaaagtat ggagcatgta tcgccagcgc ttcctgtatt ccttgtatcg      240

acatacacac tgggtacgct gtgccaaatt ttcacccgat ggaagactaa ttgtgtcatg      300

tagtgaggat aaaactatta aaatttggga taccacaaat aagcaatgtg ttaataactt      360

ctcagattcc gttggggacc tgtctttact gtttcatttt caaaaggtgg agagctattt      420

gcatcaggag gtgcagacac acaggtctta ttatggagga ctaactttga tgaattgcat      480

tgtaaaggtc ttaccaaaag aaatctcaaa agattacatt ttgattcacc accacatctt      540

cttgatatct acccaagaac accacatccc catgaggaaa aagttgagac tgtagaaatt      600

aatccaaagc ttgaggtaat cgatttgcag atctctactc cccctgttat ggatatcctt      660

tcttttgatt ctaccacaac aacagaaacc agtggtagga ctctgccaga caagggtgaa      720

gaggcctgtg gatatttctt gaacccttcc ttaatgtcac cagaatgttt gccaacaacc      780

acgaaaaaga aaacagaaga catgagtgac ctcccctgtg aaagtcaaag gagcatacct      840

ctcgctgtga ctgatgcttt agagcatatt atggaacaac tcaatgtttt gacacagact      900

gtttcaatct tggagcagcg actgactttg acagaggata agctgaaaga ctgccttgaa      960

aatcagcaaa agcttttcag tgctgtccaa cagaaaagct gaataaaaaa ttcattttca     1020

tttgttgggc agaggcccaa taaatgaaca aatgtacata cactcaggaa ggtagtacaa     1080

gatactccat acaacacaac catgtgctat ttatcatggc atttcttaaa agggtgagca     1140

acagaacaaa aggcagaaaa ggcataccta aggactaatt taaacacata tcaatgtgaa     1200

ggactaattt aaattactat catttatgat tgcagtaata aagtgataag cattcaagca     1260

actctgtatt ttccccatat tattttaaat gtccattttc atttataggc caaatcctgc     1320

caggaaagta accagatctc tggatttcac tgttaagtca tttcagattg accatattca     1380

gacagtcatg gggtgaaata attcacttac ctccaaaata gcatcctata tgccaataat     1440

gagttattga tctgactagt tgtatgtctt tctgttcaaa atagaaatta tcctttctta     1500

ctaatgcctt gaaagaatga acaaataaaa attcccagac cacagaattt ccacagcaag     1560

aatacactta ttttaattaa caatagcaca gatatagcat agggcagtgg gttttttagt     1620

taatttatgg cgtactttgt ttatccattg gccaacctga aggaaatgaa actcacctat     1680

ctttctatca cagatgaatg tgctagatga atgatttggg ttgtatctga tcatggttca     1740

caaaaattat gttagtgtgt tttcagtatg ctaaaaagtc agagtgatac aaaagtgata     1800

tttaaaaata tacacacatg tatgtacaca tgcttcagaa atattgttgc ttagggtgat     1860

ttgggcagct aaatagtaag tactttttaa aatttttgca tcatcatctt cctatttaat     1920

gaattgtgat ttaaaacaaa atgaaaataa gccaggtatt ctaaaagatc ctggatacaa     1980

attaagaatt ttgctttatt ttaaaccaaa ttgagattaa attgaagaaa agcaagcaaa     2040

ttaatttcag cttgattatc aacctgtatc aagaacaaaa atgggaggag gtgtccacat     2100

ttatggtgtg tataggtaac atggggaaaa tgctattctg tgttttggaa aagaagaaat     2160

agtgccgtcc tatttatttc tatatttaga aatttttctc aaagaaattt caattgtatc     2220

tatgagatgg gtttctaagt atcttattgt gtgttataag tgccttttaa tatcatacta     2280

agtgtgagct tctggacatt ttcaagagct tacaaaaact aagtggcatt gtatttttat     2340

aaccccattg agaagactaa gtaagaaatg aaatgtccta tcaattttat tttgtcatgc     2400

ttcaaacaat aaagacattt ctgctttaaa ag                                   2432


<210> 2041
<211> 3271
<212> DNA
<213> Homo sapiens

<400> 2041
gcgtgcgcag cggttgcctg ggcgaccggg gaagcgttgg gctgtaaaga ctagggcgcc       60

agcggctggc gaagaaggaa agagggtact ctctggctgg gctggggccg tagcgacgtc      120

cgccgcgaac ctgggccccc caaagctgcg gggcgttcgg tgtcgccgaa gtaaacatgc      180

accctgagcc ctcggagcct gcgacaggtg gtgcagcaga gctggattgc gcgcaggagc      240

ccggcgtgga ggagtctgcg ggtgaccacg ggagcgcagg ccgagggggc tgcaaggaag      300

aaattaatga tcctaaggaa atatgtgtgg gttcttctga cacatcctac cacagccagc      360

agaaacagag tggtgataat gggtcaggtg gtcacttcgc acacccaaga gaagacaggg      420

aagatcgggg ccccagaatg actaaaagtt ccctgcaaaa actctgcaag cagcacaagc      480

tttatattac cccagcattg aatgatacgc tgtatttaca ctttaaaggt tttgatcgca      540

ttgagaacct ggaagagtac acagggctgc gctgtctctg gctgcagagc aatggaatac      600

agaaaatcga aaacctggag gcccaaactg agttgcgttg cctcttcttg caaatgaact      660

tgctccgtaa aattgagaac ctggaacctc tgcagaaact ggatgctctt aacctcagca      720

acaattacat caagaccatt gaaaacctct cctgcctccc agtcctgaac acattgcaga      780

tggcccacaa tcacctggag accgtggagg acattcagca tctacaagag tgtttgaggc      840

tttgtgtcct tgacctttcg cacaacaagc tgagtgaccc ggagatcctg agcattctgg      900

aaagcatgcc cgatttgcgt gtactgaatt tgatgggaaa cccggttatc agacagattc      960

ctaattacag aaggacagtc actgtacgac taaagcactt aacatacctg gatgatagac     1020

cagtgtttcc aaaggacaga gcttgtgcgg aggcctgggc taggggaggg tacgcagctg     1080

aaaaggagga gagacagcag tgggagagca gggagcggaa gaagatcaca gacagcattg     1140

aagccttggc catgatcaag cagcgggcag aggagaggaa aagacagaga gagagtcaag     1200

agagagggga gatgacatct tcagatgatg gtgagaatgt gcccgccagt gcggaaggca     1260

aggaggagcc tcccggggac agagaaacaa ggcagaagat ggagctattt gttaaggaaa     1320

gctttgaggc caaggacgag ctctgcccgg aaaagccaag tggagaggag ccgcctgtgg     1380

aggctaaaag agaggatgga ggtccagagc cagaggggac cctcccagct gagaccctgc     1440

tactgtcgtc acctgtggag gttaaaggag aggacggaga tggagagcca gaggggaccc     1500

tcccagctga ggccccacca cccccgccac ctgtggaggt taaaggagag gatggagatc     1560

aagagccaga ggggaccctc ccagctgaga ccctgctact gtcaccgcct gtgaaggtta     1620

aaggagagga tggagatcga gagccagagg ggaccctccc agctgaggcc ccaccaccac     1680

cgcccctggg agctgccagg gaagaaccga ctccccaggc tgtggccact gagggtgtat     1740

tcgttacaga acttgatgga acgagaacgg aagatttaga aaccattaga ctggagacaa     1800

aggagacatt ctgcattgat gacctacctg acttggaaga tgatgatgaa acaggcaaat     1860

ctctggaaga ccagaatatg tgctttccga agattgaggt catctcgagc ttgagtgatg     1920

acagtgaccc tgaactggac tacacgtcac tccctgtgct ggaaaacctc cccacagaca     1980

ctctgtcaaa tatatttgca gtctctaaag acacctcaaa ggcggctcgg gtgcccttca     2040

cagacatctt taaaaaagaa gctaagaggg acttggaaat ccgaaaacaa gacaccaagt     2100

ccccaagacc cctgatccag gagctcagcg acgaggaccc ctctggccag ctactgatgc     2160

cccccacctg ccaaagagat gctgcaccac tcacttccag tggagacagg gacagcgact     2220

tccttgcagc ctcttctccg gtgccgactg agagcgccgc cacaccccca gagacgtgtg     2280

tcggagttgc ccagcccagc caagctctgc ccacgtggga cctcactgca ttcccagcac     2340

cgaaagcatc atagttttcc ccagttatat gtagcataaa tggtttaatc ataaatgtct     2400

cccttaggca tgataaacat tttaacaccc acgcgagtca gtgtatgatt gggctagctc     2460

ctgtttgtgt gagtcacatg caattccttt caccagccaa cctgaaaaaa gacctttctc     2520

ttactatgtc atcagaaacc agacagaccc gggtccctgc aaaatctcaa gtgagcattt     2580

tccccacagg aaaacagaat cttccactgc agctagagaa actccgagga agagggactt     2640

gatgctttag acatcaaaat gagaagggga gggaggaaag aaagggggga gtctgtgagg     2700

cacaacagag aattccccca aactgacatg accgtgaccc tctgctcaga gggcactatc     2760

gacagcccac aggtgccaga cccatgtccc aagggagaag gaacatcagc catcatctct     2820

ctgcatgagc tcagtgtcag gtagtagctg tggcgggacg ctgtccagcc taaaaaacgt     2880

gaccattcca attcatcttc agctgccaag tgtatttagt ccctgaacct ggatccaagg     2940

catctccctg taggaaacat cagaccgggg cagagattga caaagcaacc cacaacagca     3000

gctgccaacg gccgctgtgc ccacctcatc agcagctctg caggggcctc actccaccct     3060

caccaaacac gaggagccag cactcctggc ccccattcca ctggacagga aggcgtgaga     3120

actgagggac ctgcctgagg cccccacagc tgaggcgcag cggagccctg cctcccagca     3180

cagactaaaa tcccagcaac acaggcccac cggcacctcc agcctgcctt gcgggatgat     3240

cttcaggcga atatacaaaa tacaaaagaa a                                    3271


<210> 2042
<211> 1253
<212> DNA
<213> Homo sapiens

<400> 2042
ggggaattaa tggaagtgaa ggtgatggag ctgaaattgc agaaaaattt gttttcttca       60

ttggcagtaa aaatggggga aagactacta ttattctaag gtgtcttgac agagatgaac      120

caccaaaacc aaccttagct ttggaatata catatggaag aagagcaaaa gggcacaaca      180

caccaaaaga tatcgctcac ttttgggaac tcggtggagg aacctcttta ttggacttaa      240

tcagcatacc catcacaggt gacaccttac ggacgttttc tcttgttctc gttctggatc      300

tttcaaaacc taatgatctc tggcccacca tggaaaatct cttgcaagcc acaaaaagcc      360

atgtagacaa agtgataatg aaactgggaa agacaaatgc taaagcagtt tctgaaatga      420

gacagaagat ctggaataat atgccgaagg atcatcctga tcatgaatta attgacccat      480

ttccggtacc tctggtcata attggaagta aatatgatgt ttttcaggat tttgagtctg      540

agaagagaaa ggtaatatgc aagacacttc gatttgttgc acattattat ggagcatcat      600

taatgtttac cagtaaatca gaagctctat tactaaaaat acgtggagtt atcaaccagt      660

tggcatttgg cattgacaaa agcaaatcaa tatgtgtgga tcagaataaa ccgctgttta      720

tcacagcagg attggattct ttcggtcaaa taggatctcc tcctgttcct gaaaatgaca      780

ttggaaagct tcatgcccac tcacctatgg agttgtggaa aaaagtgtat gaaaagctct      840

ttccaccaaa gagtattaac acgctgaaag atatcaagga ccctgcgaga gatcctcagt      900

atgctgaaaa tgaagtcgat gagatgagaa ttcagaagga tctggtatta tcctaaacat      960

ttacttaatt tcatctgaaa ttttaacaca aaacctgggg tgccttggga attccttaca     1020

tttttctcta tgtatttact tagagtatct tctttactat taaaattatt taagtagtac     1080

atctatttaa ataacacact aatagtatac tgtagaaaaa ataaaaattt gatatgaata     1140

aagaaaaatt tttaaatcac ctgtcatccc accacccaga catgacttag tgttcacata     1200

aacctttttg attttccagt tttcattata ttaaagatga gtggtgattc tta            1253


<210> 2043
<211> 4019
<212> DNA
<213> Homo sapiens

<400> 2043
cggacgcgct ggaggccggt gggcggtcgc cgtagtcgcc ctcccaccac ctcgctcagg       60

tttctccggc ctggggcaag aggcctgtgg cccgcgcggg aacgcactgt ccaccctcag      120

acctgggact gggccggcgc gcggacgcta ccaagaggct gcggctcccg cccccgcggc      180

cggacgtggc gcctcccctg aggccgcggc cggagcctgg aggtggggtc ggagtcagag      240

cccggggctc tgatgtcacc gcgcggctgc gacggcccag gagcgcgtct cggcgggagc      300

ctcagagcct cactttgtcg ccaggctgga gtgcagtggc gcgatctcgg ctcactacaa      360

cttccgcctc ccgggttcaa gcgattcttc tgcctcagcc tcccgagtag ctgggactac      420

aggcgtgtgc caccacgccc agctaatttt tgggaaagat cacatggaga agccaacaga      480

acggccagga agcagcctgg gtggaacagg gttggggagg aaaggaacat gggtacattc      540

tcagcgttcc aggaggtctc agggtaaagg ctgcttgtgt gggcaagggg agcctggcag      600

ggaatgagct ggtcccaatt ccttcccctg agctgggccc tcaaccttca gaggtgctcc      660

ctgggactgg tcctacttcc tctgccacct ctgatcccaa ggtgactctg ccaaaatctg      720

ggggatgcca gcgcttgtga cggtgtgacc agggagggga agtgacccac gcagccaccc      780

agcctcagca ctcatctgcg cagccatgga ggccctggga cctgggggcg accgcgcctc      840

cccggcctcg tccactagca gcctggacct gtggcatctg tccatgcgcg cggactcggc      900

ctacagctct ttctccgcag cctccggcgg ccccgagccg cgcacgcagt cgccggggac      960

agacctcctt ccttacctag actgggacta cgtgcgtgtg gtttggggcg gcccgggccc     1020

cgccccgccc gacgctgccc tttgcacatc cccgcggccc cggcccgcgg ttgcagcccg     1080

cagtgggccg cagccaacag aggtcccggg gaccccggga ccactgaaca ggcaggccac     1140

cccgctgctg tacgcgctgg cggccgaggc ggaggccgcg gcgcaggctg ccgagccgcc     1200

cagcccgccg gcctcgaggg ccgcctaccg ccagcggctt cagggcgcgc agcggcgagt     1260

gctccgggag acgtcgttcc agcgcaagga gctccgcatg agcctgcccg cccgtctgcg     1320

gcccactgtc ccagcgcggc ccccggcgac tcacccgcgc tccgcctcgc tcagccaccc     1380

gggcggggag ggggagccgg cgcgctcccg ggctcccgcg ccaggaactg ccggccgggg     1440

tcccctcgcc aaccagcagc ggaagtggtg cttctcagag ccaggaaagc tggatcgtgt     1500

gggtcggggc ggtgggccgg cgcgggaatg cctgggtgag gcctgctcca gctctggcct     1560

ccctgggccc gagcccttgg agttccagca tccggcgctg gctaagtttg aagatcacga     1620

ggtcggatgg ctgcccgaga cgcaacccca aggctccatg aacctggact ccgggtcctt     1680

gaagctcggt gatgccttca ggcccgccag tcggagtcgg agcgcttcag gcgaagtctt     1740

gggttcctgg ggaggatcag gagggaccat acccattgtc caggctgttc cccaaggagc     1800

agaaaccccc agaccattgt ttcagaccaa actttccagg ttcttgcctc agaaagaggc     1860

tgcggtgatg tatcctgcag agttacccca gagcagccct gctgacagtg aacagagggt     1920

ctcagagacc tgcattgtgc ctgcctggct cccctccctt cctgatgaag tgttcctaga     1980

agaggcccca ctggtcagaa tgagatcacc accagacccc catgcctccc aggggccccc     2040

agccagtgtc catgcctctg accagccgta tggaactggc ttaggccaaa gaactggcca     2100

ggttacagtc cccacagagt acccgctcca tgagtgtcca ggaactgcag gggcagatga     2160

ctgctggcag ggggtgaatg gttctgtagg tatttccagg cccacaagcc acacccccac     2220

tgggactgca aatgataaca tcccaactat tgaccccact ggactgacca ccaatccccc     2280

cacagctgca gagagtgacc tcctcaaacc tgtcccagct gatgccttgg gactttcagg     2340

caatgatact ccaggtccct ctcacaatac tgccctagcc aggggcactg gccagcctgg     2400

ttccaggccc acatggccta gtcagtgcct cgaggagctg gttcaggagc tggccagatt     2460

agatccctct ctatgtgacc ctcttgcttc ccagcccagc ccagagccac ccctgggcct     2520

gctggatgga ctgattcctt tagcagaggt ccgggctgca atgcggcctg cctgtgggga     2580

ggctggagag gaggctgcca gtacttttga gccagggtcc tatcagttca gcttcaccca     2640

gctcctgccg gctcctcggg aggagacaag gcttgaaaac cctgccaccc accctgtgct     2700

tgaccagcca tgtgggcagg ggctccctgc accaaacaac agcatccagg gcaagaaagt     2760

ggagctggcc gcccgcctcc aaaagatgct tcaggacctt cacacggagc aggagcggct     2820

gcagggggag gcacaagcgt gggccaggcg ccaagcggct ctggaggctg cagtgcgcca     2880

ggcctgtgcc cctcaggagc tggagcggtt cagccggttc atggccgacc tagagcgcgt     2940

gcttggcctt ctgctgctgc tgggcagtcg cctggcgcgc gtgcgccgcg ccctggcccg     3000

ggcggcctca gacagcgacc ctgatgagca ggcctccctg ctgcagcgac tccggctcct     3060

gcagcggcag gaggaggacg ccaaggagct gaaggagcac gtagcgcggc gcgagcgggc     3120

cgtgcgggag gtgctggtgc gagcactacc ggtggaggag ctgcgcgtct attgcgccct     3180

gctggcgggc aaggccgccg tcctggccca gcagcgcaac ctggacgagc gcatccgcct     3240

ccttcaggac caactggacg ccatcaggga cgaccttggc catcatgccc cgtctcccag     3300

cccggcgcgg cccccaggga cctgtcctcc agttcagccg cccttccctc ttctccttac     3360

atagttatag gtggagaggg tggggtgcac cgcccctatc tctcacccac gtaagtgggg     3420

tgatgctgat ttagtctctg cttttccctt gagggattgg ggaggaccca gtccaggcct     3480

ttctaagata ctcctccagc cgggcgcggt ggctcacgcc tgtaatccca gcactttggg     3540

aggccgaggc gggcggatca caaggtcagg agatcgagac catcctggct aacacggtga     3600

aaccccgtct ctactaaaaa tataaaaaat tagccgggcg tggtggcggg tgcctgtatt     3660

gccagctact cggaaggctg aggcaggaga atggcgtgaa cctgggaggt ggagcttgca     3720

gtgagcggac atcgcgccac tgcactccag cctgggcgac agagcaagac tccgtctcaa     3780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaga tacttctcca aagtgttctc atgtggcctc     3840

acccaggtct tgtgtattat ttggtaatta atttatggat cttaaaaact gcagtattcc     3900

cccattttgt gatgagagtg tggggctggc aggggttggt tggagggagg agagaagaca     3960

gaggagcact taaggtgcaa agcagcctat tttttcttca ataaaaattg ttaagagaa      4019


<210> 2044
<211> 2134
<212> DNA
<213> Homo sapiens

<400> 2044
gtcccgcggg cgcggagaag gcgggtgacg gtgtgacccg aactgcctct tttctaaaga       60

ggactccaaa ggaaggactg gtcatctctt tcatatctca aaaccatggc tcagggatca      120

gtgtctttca atgatgtgac tgtggacttc actcaggagg agtggcagca cctggatcat      180

gctcagaaga ctctatatat ggatgtgatg ttggaaaact attgccacct catctctgtg      240

gggtgtcaca tgaccaaacc tgatgtgatc ctcaagttgg aacgaggaga agagccatgg      300

acatcatttg caggtcatac ctgcttggaa gaaaactgga aagctgaaga ctttttagtg      360

aaattcaagg aacaccaaga gaagtattct agatcagttg taagcatcaa ccacaaaaaa      420

ctggtgaagg agaagagtaa aatatatgaa aagacattta ctctaggcaa aaaccctgtg      480

aattcaaaaa atctacctcc tgaatatgat actcatggaa ggattttgaa aaatgtttca      540

gaattaatca tcagtaatct aaatcctgca agaaagagac ttagtgagta taatggatat      600

gggaaatcac tcctgagtac taaacaagag actactcatc ctgaagtcaa atcccataat      660

caaagtgcca gagctttcag tcataatgaa gttcttatgc agtatcagaa aacggaaact      720

ccagcacagt catttggata taatgactgt gagaaatcat tccttcaaag gggaggcctg      780

attacacata gtagacctta caaaggagaa aacccatctg tatataataa aaaaagaaga      840

gcaaccaata ttgaaaaaaa acatacatgc aatgaatgtg ggaaatcttt ctgcaggaaa      900

tcagtattga ttctgcatca gggaattcac tcagaagaaa aaccctatca atgtcatcaa      960

tgtggaaatg catttagaag gaaatcatat ctcattgatc atcagagaac tcacacagga     1020

gagaaaccat atgagtgtaa tgactgtggg aagtccttcc gccagaagac aacactctct     1080

ctacatcaga gaatccatac aggtgagaaa ccctacattt gtaaagaatg tgggaagtcc     1140

tttcaccaga aggcaaatct tactgtacat cagagaactc atacagggga aaagccctat     1200

atttgtaatg aatgtgggaa atccttctcc cagaagacaa cccttgctct tcatgagaaa     1260

actcataatg aggagaaacc ctatatttgt agtgaatgtg gaaagtcctt ccgccagaag     1320

acaacccttg tagcacatca gagaacacat acaggggaga aatcttatga atgtcctcac     1380

tgtgggaagg cctttagaat gaagtcatac ctcattgatc atcaccgaac tcacacagga     1440

gagaaaccat atgaatgtaa tgaatgtggt aaatcattca gtcaaaagac aaatctcaat     1500

ctacatcaga gaattcatac aggggagaaa ccctatgttt gtaatgaatg tgggaagtcc     1560

tttcgccaga aagcaaccct cactgtacat cagaaaatac ataccggcca gaaatcctat     1620

gaatgtcctc agtgtgggaa agcctttagc aggaagtcat atctcattca tcatcaaaga     1680

actcatacgg gagagaaacc atataaatgt agtgaatgtg gaaagtgctt ccgccagaag     1740

acaaatctta ttgtacatca gagaactcac acaggtgaga aaccctatgt ttgtaatgag     1800

tgtggtaagt ctttcagtta taagagaaac ctcattgtcc atcaaagaac tcacaaggga     1860

gaaaacattg aaatgcaata aatgatgtgg tttcttatat gaattcttta caagctgttg     1920

taaacattta gttttaaaaa gaaaagcatg ctgaaacatg ttaatgtaat tttaaatcac     1980

aagtctaata attattaaag taccatacgg aataactgtc tactgtttac tagcatataa     2040

aataagtatg atcattatta ttgaactcta tcagctatga agctaaattt taaagtcaac     2100

tgctcttcct actgactcaa atagtttatt tttt                                 2134


<210> 2045
<211> 3230
<212> DNA
<213> Homo sapiens

<400> 2045
acttccggtg cttgccctgc ccatccccgt ggcgggggcg tggccatggc gggggcgctc       60

cggcgggggc gggccctggg ctcccgccct tcgggtccca cagtttccag ccgccgctct      120

cctcagtgcc cggtggccca ggagggcctg ggagcccgaa gccgtccccg agtcgctcct      180

aggtcactgg cgcgatgcgg gccgtcctct cggctgatgg gttggaagcc cagcgaggct      240

agaggccagt cccaaagttt ccaggcatca gggctgcagc ccaggagcct caaggcggcc      300

cggcgggcga ctggacggcc ggacaggtcc cgagcagccc ggcccaccat ggacccctct      360

gcccacaggt cccgagcagc cccgcccaac atggacccag acccccaggc gggcgtgcag      420

gtgggcatgc gggtggtgcg cggcgtggac tggaagtggg gccagcagga cggcggcgag      480

ggcggcgtgg gcacggtggt ggagcttggc cgccacggca gcccctcgac acccgaccgc      540

acagtggtcg tgcagtggga ccagggcacg cgcaccaact accgcgccgg ctaccagggc      600

gcgcacgacc tgctgctgta cgacaacgcc cagatcggcg tccggcaccc caacatcatc      660

tgtgactgct gcaagaagca cgggctgcgg gggatgcgct ggaagtgccg tgtgtgcctg      720

gactacgacc tctgcacgca gtgctacatg cacaacaagc atgagctcgc ccacgccttc      780

gaccgctacg agaccgctca ctcgcgccct gtcacactga gtccccgcca gggcctcccg      840

aggatcccac taaggggcat cttccaggga gcgaaggtgg tgcgaggccc cgactgggag      900

tggggctcac aggatggagg ggaagggaaa ccgggccgtg tggtggacat ccgtggctgg      960

gatgtggaga caggccggag tgtggccagc gtgacgtggg ctgatggtac caccaatgtg     1020

taccgtgtgg gccacaaggg caaggtggac ctcaagtgtg tgggcgaggc agcgggcggc     1080

ttctactaca aggaccacct cccaaggctc ggcaagccgg cggagctgca gcgcagggtg     1140

agtgctgaca gccagccctt ccagcacggg gacaaggtca agtgtctgct ggacactgat     1200

gtcctgcggg agatgcagga aggccacggc ggctggaacc ccaggatggc ggagcaccac     1260

tccttctggg tgggcgacgt ggtccgggtc atcggcgacc ttgacacagt gaagcggctg     1320

caggctgggc atggcgagtg gacggacgac atggcccctg ccctgggccg cgtcgggaag     1380

gtggtgaaag tgtttggaga cgggaacctg cgtgtagcag tcgctggtca gcggtggacc     1440

ttcagcccct cctgcctggt ggcctaccgg cccgaggagg atgccaacct ggacgtggcc     1500

gagcgcgccc gggagaacaa aagctcactg agcgtggccc tggacaagct tcgggcccag     1560

aagagtgacc cagagcaccc gggaaggctg gtggtggagg tggcgctggg taacgcagcc     1620

cgggctctgg acctgctgcg gaggcgccca gagcaggtgg acaccaagaa ccaaggcagg     1680

accgctctgc aagtggctgc ctacctgggc caggtggagt tgatacggct gctgctacaa     1740

gccagggcgg gcgtggacct gccggacgac gagggcaaca cggcactgca ctacgcggcc     1800

ctggggaacc agcccgaggc caccagggtg ctcctgagtg ctgggtgccg ggcggacgcc     1860

atcaacagca cccagagcac agcactgcac gtggccgtgc agaggggctt cctggaggtg     1920

gtgcgggccc tgtgtgagcg cggctgtgac gtcaacctgc ccgacgccca ctcggacacg     1980

cccctgcact ccgccatctc ggcgggcact ggagccagcg gcattgtcga ggtcctcacg     2040

gaggtgccaa acatcgatgt taccgccacc aacagccagg gtttcaccct gctgcaccat     2100

gcctccctca agggtcacgc gctagctgtg agaaagattc tggctcgggc gcggcagctg     2160

gtggacgcca agaaggagga cggcttcacg gcgctgcatc tggctgccct caacaaccac     2220

cgcgaggtgg cccagatcct catccgggag ggccgctgtg acgtgaacgt gcgcaaccgg     2280

aagctgcagt ccccgctgca tctcgccgtg caacaggccc acgtggggct ggtgccgcta     2340

ctggtggacg ctgggtgcag tgtcaacgcc gaggacgagg agggggacac agccctgcac     2400

gtggcgctgc agcgtcatca gctgctgccc ctggtggctg atggggccgg gggggaccca     2460

gggcccttgc agctgctgtc caggctacag gcctcgggcc tccccggcag cgcggagctg     2520

acggtgggcg cggcggtcgc ctgcttcctg gcgctggagg gcgccgacgt gagctacacc     2580

aaccaccgcg gtcggagccc gctggacctg gccgccgagg gtcgcgtgct caaggccctt     2640

cagggctgcg cccagcgctt ccgggagcgg caggcgggcg ggggcgcggc cccgggcccc     2700

aggcaaacgc tcgggacccc caacaccgtg acgaacctgc acgtgggcgc cgcgccgggg     2760

cccgaggccg ctgagtgcct ggtgtgctcc gagctggcgc tgctggtgct gttctcgccg     2820

tgccagcacc gcaccgtgtg tgaggagtgc gcgcgcagga tgaagaagtg catcaggtgc     2880

caggtggtcg tcagcaagaa actgcgccca gacggctctg aggtggcgag cgccgccccc     2940

gcccccggcc cgccgcgcca gctggtggag gagctgcaga gccgctaccg gcagatggag     3000

gaacgcatca cctgccccat ctgcatcgac agccacatcc gcctcgtgtt ccagtgcggc     3060

cacggcgcat gcgccccctg cggctccgcg ctcagcgcct gccccatctg ccgccagccc     3120

atccgcgacc gcatccagat cttcgtgtga gccgcgccgt ccgccgcgcc cgagctgcct     3180

tcgcgtgccc ccgccctgtg ttttataaaa agaaagattc tcggacgttg                3230


<210> 2046
<211> 2890
<212> DNA
<213> Homo sapiens

<400> 2046
gctggggtcg tcgtccgggc cgggtgggct gcggcgcgcg gcaggcgctc tggcctggcc       60

tggccgccgc tgagcagtcg gggccggtgg gtggcctcga acgccgggac agaccgacag      120

acggactggc cggcggtccc gcgcccccga gcggagcggg cgggacggaa acgtccgggc      180

aagttggggt cggcagggtt ggaagcccag cgaggctaga ggccagtccc aaagtttcca      240

ggcatcaggg ctgcagccca ggagcctcaa ggcggcccgg cgggcgactg gacggccgga      300

caggtcccga gcagccccgc ccaacatgga cccagacccc caggcgggcg tgcaggtggg      360

catgcgggtg gtgcgcggcg tggactggaa gtggggccag caggacggcg gcgagggcgg      420

cgtgggcacg gtggtggagc ttggccgcca cggcagcccc tcgacacccg accgcacagt      480

ggtcgtgcag tgggaccagg gcacgcgcac caactaccgc gccggctacc agggcgcgca      540

cgacctgctg ctgtacgaca acgcccagat cggcgtccgg caccccaaca tcatctgtga      600

ctgctgcaag aagcacgggc tgcgggggat gcgctggaag tgccgtgtgt gcctggacta      660

cgacctctgc acgcagtgct acatgcacaa caagcatgag ctcgcccacg ccttcgaccg      720

ctacgagacc gctcactcgc gccctgtcac actgagtccc cgccagggcc tcccgaggat      780

cccactaagg ggcatcttcc agggagcgaa ggtggtgcga ggccccgact gggagtgggg      840

ctcacaggat ggcaagccgg cggagctgca gcgcagggtg agtgctgaca gccagccctt      900

ccagcacggg gacaaggtca agtgtctgct ggacactgat gtcctgcggg agatgcagga      960

aggccacggc ggctggaacc ccaggatggc ggagtttatc ggacagacgg gcaccgtgca     1020

tcgtatcacg gaccgcgggg acgtgcgcgt gcagttcaac cacgagacgc gctggacctt     1080

ccaccccggg gcgctcacca agcaccactc cttctgggtg ggcgacgtgg tccgggtcat     1140

cggcgacctt gacacagtga agcggctgca ggctgggcat ggcgagtgga cggacgacat     1200

ggcccctgcc ctgggccgcg tcgggaaggt ggtgaaagtg tttggagacg ggaacctgcg     1260

tgtagcagtc gctggtcagc ggtggacctt cagcccctcc tgcctggtgg cctaccggcc     1320

cgaggaggat gccaacctgg acgtggccga gcgcgcccgg gagaacaaaa gctcactgag     1380

cgtggccctg gacaagcttc gggcccagaa gagtgaccca gagcacccgg gaaggctggt     1440

ggtggaggtg gcgctgggta acgcagcccg ggctctggac ctgctgcgga ggcgcccaga     1500

gcaggtggac accaagaacc aaggcaggac cgctctgcaa gtggctgcct acctgggcca     1560

ggtggagttg atacggctgc tgctacaagc cagggcgggc gtggacctgc cggacgacga     1620

gggcaacacg gcactgcact acgcggccct ggggaaccag cccgaggcca ccagggtgct     1680

cctgagtgct gggtgccggg cggacgccat caacagcacc cagagcacag cactgcacgt     1740

ggccgtgcag aggggcttcc tggaggtggt gcgggccctg tgtgagcgcg gctgtgacgt     1800

caacctgccc gacgcccact cggacacgcc cctgcactcc gccatctcgg cgggcactgg     1860

agccagcggc attgtcgagg tcctcacgga ggtgccaaac atcgatgtta ccgccaccaa     1920

cagccagggt ttcaccctgc tgcaccatgc ctccctcaag ggtcacgcgc tagctgtgag     1980

aaagattctg gctcgggcgc ggcagctggt ggacgccaag aaggaggacg gcttcacggc     2040

gctgcatctg gctgccctca acaaccaccg cgaggtggcc cagatcctca tccgggaggg     2100

ccgctgtgac gtgaacgtgc gcaaccggaa gctgcagtcc ccgctgcatc tcgccgtgca     2160

acaggcccac gtggggctgg tgccgctact ggtggacgct gggtgcagtg tcaacgccga     2220

ggacgaggag ggggacacag ccctgcacgt ggcgctgcag cgtcatcagc tgctgcccct     2280

ggtggctgat ggggccgggg gggacccagg gcccttgcag ctgctgtcca ggctacaggc     2340

ctcgggcctc cccggcagcg cggagctgac ggtgggcgcg gcggtcgcct gcttcctggc     2400

gctggagggc gccgacgtga gctacaccaa ccaccgcggt cggagcccgc tggacctggc     2460

cgccgagggt cgcgtgctca aggcccttca gggctgcgcc cagcgcttcc gagtgcgcgc     2520

gcaggatgaa gaagtgcatc aggtgccagg tggtcgtcag caagaaactg cgcccagacg     2580

gctctgaggt ggcgagcgcc gcccccgccc ccggcccgcc gcgccagctg gtggaggagc     2640

tgcagagccg ctaccggcag atggaggaac gcatcacctg ccccatctgc atcgacagcc     2700

acatccgcct cgtgttccag tgcggccacg gcgcatgcgc cccctgcggc tccgcgctca     2760

gcgcctgccc catctgccgc cagcccatcc gcgaccgcat ccagatcttc gtgtgagccg     2820

cgccgtccgc cgcgcccgag ctgccttcgc gtgcccccgc cctgtgtttt ataaaaagaa     2880

agattctcgg                                                            2890


<210> 2047
<211> 1444
<212> DNA
<213> Homo sapiens

<400> 2047
gcgggcaggc gactcctgtc ccgggtggag gcggcggagc cggagccggg ggagggggca       60

gcggctgtct cacggaccac ggcggcgccc gcagctcctc accgcagcac ccccactgca      120

ggcccgagga gctttccgga gcttcccaca ctcctgggga gaagacttct tagccagctt      180

gatgtttaaa attcagctgg agcccttaaa acttcgagcg tggacgctga atgggtttgt      240

aaagtttcga aacaaggaga ccagtgctgg tccagtggct gtgatgggaa aagattatta      300

caagattctt gggatcccat cgggggccaa cgaggatgag atcaagaaag cctaccggaa      360

gatggccttg aagtaccacc cagacaagaa taaagaaccc aacgctgagg agaagtttaa      420

ggagattgca gaggcctatg atgtgctaag tgaccccaag aaacggggcc tgtatgacca      480

gtatggggag gaaggcctga agaccggcgg tggcacatca ggtggctcca gtggctcctt      540

tcactacacc tttcatgggg acccccatgc cacctttgcc tccttctttg gtggctccaa      600

ccccttcgat atcttctttg ccagcagccg ctccactcgg cccttcagtg gctttgaccc      660

agatgacatg gatgtggatg aagatgagga cccatttggc gctttcggcc gttttggctt      720

caatgggctg agtaggggtc caaggcgagc cccagaacca ctgtaccctc ggcgcaaggt      780

gcaggacccc ccagtggtgc acgagctgcg ggtgtccctg gaggagatct accatggctc      840

caccaagcgc atgaagatca caaggcgtcg cctcaaccct gatgggcgaa ctgtgcgcac      900

cgaggacaag atcctgcaca tagtcatcaa gcgtggctgg aaggaaggca ccaagatcac      960

cttccccaaa gaaggcgacg ccacacctga caacatccct gctgacatcg tctttgtgct     1020

caaagacaag ccccatgcac acttccgccg agatggcacc aacgtgctct acagtgccct     1080

gatcagcctc aaggaggcgc tgtgtggctg cactgtgaac attcccacta tcgacggccg     1140

agtgatccct ttgccctgca atgatgtcat caagccaggc accgtgaaga gactccgtgg     1200

ggagggcctt cccttcccca aagtgccaac tcagcgagga gacctcattg ttgagttcaa     1260

agttcgcttc ccagacagat taacaccaca gacaagacag atccttaagc agcaataccc     1320

ccaacactca ctccactcaa tgtgcaccca gcttgatgtc cactggacac tggcaacttt     1380

ttctaaaatg caaaaaaaag ccactggttt tcaggaaaat gttcctgtcc ctgacccctt     1440

ttag                                                                  1444


<210> 2048
<211> 2255
<212> DNA
<213> Homo sapiens

<400> 2048
gtcggtgtct gctgcgttca cggcaggatt cggttaggag gaacagcaca gcatgctggg       60

ctctggattt aaagctgagc gcttaagagt gaatttgaga ttagtcataa atcgccttaa      120

actattggag aaaaagaaaa cggaactggc ccagaaagca aggaaggaga ttgctgacta      180

tctggctgct gggaaagatg aacgagctcg gatccgtgtg gagcacatta tccgggaaga      240

ctacctcgtg gaggccatgg agatcctgga gctgtactgt gacctgctgc tggctcggtt      300

tggccttatc cagtctatga aggaactaga ttctggtctg gctgaatctg tgtctacatt      360

gatctgggct gctcctcgac tccagtcaga agtggctgag ttgaaaatag ttgctgatca      420

gctctgtgcc aagtatagca aggaatatgg caagctatgt aggaccaacc agattggaac      480

tgtgaatgac aggctaatgc acaagctgag tgtggaagcc ccacccaaaa tcctggtgga      540

gagatacctg attgaaattg caaagaatta caacgtaccc tatgaacctg actctgtggt      600

catggcagaa gctcctcctg gggtagagac agatcttatt gatgttggat tcacagatga      660

tgtgaagaaa ggaggccctg gaagaggagg gagtggtggc ttcacagcac cagttggtgg      720

acctgatgga acggtgccaa tgcccatgcc catgcccatg cctatgccat ctgcaaatac      780

gcctttctca tatccactgc caaagggacc agtagatgac attaatgctg ataagaatat      840

ctcttctgca cagattgttg gtcctggacc caagccagaa gcctctgcaa agcttccttc      900

cagacctgca gataactatg acaactttgt cctaccagag ttgccatctg tgccagacac      960

actaccaact gcatctgctg gtgccagcac ctcagcatct gaagacattg actttgatga     1020

tctttcccgg aggtttgaag agctgaaaaa gaaaacatag gtctcttaaa ccaggcaact     1080

ttcacgtttt gggagttgag actgagcaat ttctccttgt aacaaagaat ctccatgaaa     1140

ttctgtttca tctgttaacc gtcactcagc acaacactcc ctctgggctc tcttcctgct     1200

cctccagatt ctgctgcttt ccagttctct gttgatcctg agactaacaa ttggagactg     1260

aggccagagc aactggctcc tggcagctgt gcttgtccgt ttcctgtcag agtgatccca     1320

ggtttcctcc tggcccgtcc catggtccct ccacaggagt gtgagaggat gggggaagca     1380

ctgtgggaag accaccaaag atggctggac agtgggagag agcacgttgt gaagcatccc     1440

agcctcgtgt tgaggttcca gacttagaaa cagacccctc tgtacagggg gattgtggtg     1500

agtgagaatc aaggccacct tgtgtgtttt ctcactctcg aatgcaagtg ggagagggaa     1560

aatgactcgg gacgccattg taacggttcc tggaagctgg gccctctcat tggcatatac     1620

agtactcctc gctgcagggc actgtcccac cgggatccag ttgcaaagtt tgtcttgaca     1680

gttgaaggcc tcgcttagtt gtactggatt ctcagggagc cctctgtggc cttttgcttt     1740

gcgtgctgtt tcccttgtac cagagggcgg caccgtggaa attctgtttt ccctgtagca     1800

tattgtgttg gattgcatta ctggcagaga aaggacaagg tgccattcaa gtcctagggt     1860

gggcttccag ctgccttaat agaagtactc aagtcttttg ggtagtgagc tggaaagcct     1920

acaggaaaag aggggtacct gttttcattt gaaaactttg attcatggaa cctttaaaac     1980

taatctcaga aaaatttttg gtgcccatgc agctgtagtt gttcactgct ttcctggatg     2040

gatgggactc ttatgtcata acttctgtta ctcctttggc ccatagctaa ggtcatcctt     2100

ccccacaggg gtggctttgg gattggatga tacagctttt gcttctgtgt agtatacctg     2160

tacatacttg tttcaggcag cctttcttta atgttttcag ttggtttgta ttctgtagct     2220

cagtagctgc taataaagtt aaagatcctg tgtcc                                2255


<210> 2049
<211> 2654
<212> DNA
<213> Homo sapiens

<400> 2049
ctgtggctgg cctccccgcg cccagagcga aattaagggc atgcccccag cagctgactc       60

agtcggcgtg gcgcttcccc caacgtctgc cgtgcccccg ccgcgggaag tagtccccgg      120

ccgcgccgac tccaaaggaa accgagggag ggtgccccga gtcagcgcgt gggtcccggc      180

agcggcgatc gcgcagccaa tccctggaaa ggagggcgtg gctatatcgg ccccgtggat      240

ccctccgccc gcgcttgttg tgctgaggcc gagggagtcg ccattttgga tggtgaaccc      300

tgaagtcggt gtctgctgcg ttcacggcag gattcggtta ggaggaacag cacagcatgc      360

tgggctctgg atttaaagct gagcgcttaa gagtgaattt gagattagtc ataaatcgcc      420

ttaaactatt ggagaaaaag aaaacggaac tggcccagaa agcaaggaag gagattgctg      480

actatctggc tgctgggaaa gatgaacgag ctcggatccg tgtggagcac attatccggg      540

aagactacct cgtggaggcc atggagatcc tggagctgta ctgtgacctg ctgctggctc      600

ggtttggcct tatccagtct atgaaggaac tagattctgg tctggctgaa tctgtgtcta      660

cattgatctg ggctgctcct cgactccagt cagaagtggc tgagttgaaa atagttgctg      720

atcagctctg tgccaagtat agcaaggaat atggcaagct atgtaggacc aaccagattg      780

gaactgtgaa tgacaggcta atgcacaagc tgagtgtgga agccccaccc aaaatcctgg      840

tggagagata cctgattgaa attgcaaaga attacaacgt accctatgaa cctgactctg      900

tggtcatggc agaagctcct cctggggtag agacagatct tattgatgtt ggattcacag      960

atgatgtgaa gaaaggaggc cctggaagag gagggagtgg tggcttcaca gcaccagttg     1020

gtggacctga tggaacggtg ccaatgccca tgcccatgcc catgcctatg ccatctgcaa     1080

atacgccttt ctcatatcca ctgccaaagg gaccatcaga tttcaatgga ctgccaatgg     1140

ggacttatca ggcctttccc aatattcatc cacctcagat accagcaact cccccatcgt     1200

atgaatctgt agatgacatt aatgctgata agaatatctc ttctgcacag attgttggtc     1260

ctggacccaa gccagaagcc tctgcaaagc ttccttccag acctgcagat aactatgaca     1320

actttgtcct accagagttg ccatctgtgc cagacacact accaactgca tctgctggtg     1380

ccagcacctc agcatctgaa gacattgact ttgatgatct ttcccggagg tttgaagagc     1440

tgaaaaagaa aacataggtc tcttaaacca ggcaactttc acgttttggg agttgagact     1500

gagcaatttc tccttgtaac aaagaatctc catgaaattc tgtttcatct gttaaccgtc     1560

actcagcaca acactccctc tgggctctct tcctgctcct ccagattctg ctgctttcca     1620

gttctctgtt gatcctgaga ctaacaattg gagactgagg ccagagcaac tggctcctgg     1680

cagctgtgct tgtccgtttc ctgtcagagt gatcccaggt ttcctcctgg cccgtcccat     1740

ggtccctcca caggagtgtg agaggatggg ggaagcactg tgggaagacc accaaagatg     1800

gctggacagt gggagagagc acgttgtgaa gcatcccagc ctcgtgttga ggttccagac     1860

ttagaaacag acccctctgt acagggggat tgtggtgagt gagaatcaag gccaccttgt     1920

gtgttttctc actctcgaat gcaagtggga gagggaaaat gactcgggac gccattgtaa     1980

cggttcctgg aagctgggcc ctctcattgg catatacagt actcctcgct gcagggcact     2040

gtcccaccgg gatccagttg caaagtttgt cttgacagtt gaaggcctcg cttagttgta     2100

ctggattctc agggagccct ctgtggcctt ttgctttgcg tgctgtttcc cttgtaccag     2160

agggcggcac cgtggaaatt ctgttttccc tgtagcatat tgtgttggat tgcattactg     2220

gcagagaaag gacaaggtgc cattcaagtc ctagggtggg cttccagctg ccttaataga     2280

agtactcaag tcttttgggt agtgagctgg aaagcctaca ggaaaagagg ggtacctgtt     2340

ttcatttgaa aactttgatt catggaacct ttaaaactaa tctcagaaaa atttttggtg     2400

cccatgcagc tgtagttgtt cactgctttc ctggatggat gggactctta tgtcataact     2460

tctgttactc ctttggccca tagctaaggt catccttccc cacaggggtg gctttgggat     2520

tggatgatac agcttttgct tctgtgtagt atacctgtac atacttgttt caggcagcct     2580

ttctttaatg ttttcagttg gtttgtattc tgtagctcag tagctgctaa taaagttaaa     2640

gatcctgtgt cctg                                                       2654


<210> 2050
<211> 1567
<212> DNA
<213> Homo sapiens

<400> 2050
atggaaaagt atgaaaaatt agctaagact ggagaagggt cttatggggt tgtattcaaa       60

tgcagaaaca aaacctctgg acaagtagta gctgttaaaa aatttgtgga atctgaagat      120

gatcctgttg ttaagaaaat agcactaaga gaaatacgta tgttgaagca attaaaacat      180

ccaaatcttg tgaacctcat cgaggtgttc aggagaaaaa ggaaaatgca tttagttttt      240

gaatactgtg atcatacact tttaaatgag ctggaaagaa acccaaatgg agttgctgat      300

ggagtgatca aaagcgtatt atggcaaaca cttcaagctc ttaatttctg tcatatacat      360

aactgtattc acagagatat aaaacctgaa aatattctaa taactaagca aggaataatc      420

aagatttgtg acttcgggtt tgcacaaatt ctgattccag gagatgccta caccgattat      480

gtagctacga gatggtaccg agctcctgaa cttcttgtgg gagatactca gtatggttct      540

tcagtcgata tatgggctat tggttgtgtt tttgcagagc tcctgacagg ccagccactg      600

tggcctggaa aatcagatgt ggaccaactt tatctgataa tcagaacact aggaaaatta      660

atcccaagac atcaatcaat ctttaaaagt aacgggtttt tccatggcat cagtatacct      720

gagccagaag acatggaaac tcttgaggaa aagttctcag atgttcatcc tgtggctctg      780

aacttcatga aggggtgtct gaagatgaat ccagatgaca gattaacctg ttcccaactc      840

ctggagagct cctactttga ttcttttcaa gaggcccaaa ttaaaagaaa agcacgtaat      900

gaaggaagaa acagaagacg ccaacaggta cttccgctca aaagttaaag tgctataaaa      960

ataattcctt ttttgttttt gtttgtctgc ctttcaaagt gagacaaggt ggacaccaag     1020

acctttcatt tgtactggtg tagttgtatt tgtctagctt aataaatatt ggtaattgat     1080

gtaataaaac catagaacta tgaaaatatc aagattattg caaaaatctt attccaaaca     1140

cacctgaatc aaatcgttac gcaactcttt ggctgctctg attggatatc ccacccacaa     1200

gatcgtatac ccataatata acaacttcat ataataaaat gctgattcca acaggactga     1260

gttttgccag cattgcaaag gaatccaagt gcctttctgt agcctccaga tgtgcaataa     1320

cggtaacttg actcttccat cttttcaccc acagcaggca cctaagtctg cctttcctag     1380

gctttttctc aaaaccaaga tctgccaggt acaaaggaat gaaacccaga catctgggaa     1440

ccaaattcta cccaatgggc caatattgca gaacagtatg gtgactgtta tgacaaacat     1500

taattctgca gtttatcagg tgactgtcct tcacttgctt tcagaaaact ttgaagttaa     1560

atcgtaa                                                               1567


<210> 2051
<211> 2386
<212> DNA
<213> Homo sapiens

<400> 2051
aggcgcagtc ccgcgttccc tcggcggctg ccggcgtagt gagcccgccg ccgtggagtg       60

tagcggaaag ggctcgccgt cctcctccgt ttctcgctgc ttcgggacgc gctctctgcg      120

gctctgtgag cgcccctgag cgccggcagc ggccgcggtg ggttcttcag gttatcttat      180

gatgaggctt ttgctatggc taatgatccc ttggaaggct tccatgaagt aaaccttgct      240

tcacctactt ctccggacct tcttggtgtg tatgaatcag gaactcaaga gcagactacc      300

tcaccaagtg tcatctaccg gccacaccct tcagctttat cctctgtacc tatccaggca      360

aatgcattag atgtttctga acttcctaca caacccgtgt attcatcccc cagacgttta      420

aattgtgcgg aaatatctag tatcagcttt catgttacag acccagcccc ttgctctacc      480

tctggagtca cagctggatt aactaaatta actacaagaa aggacaacta taatgcagag      540

agagagtttt tacagggtgc tactataaca gaggcttgcg atggcagtga tgatattttt      600

gggttgagta ctgatagtct gtctcgttta cgaagcccat ctgttttgga agttagagaa      660

aagggctatg aacgattaaa agaagaactc gcaaaagctc agagggaact gaagttaaaa      720

gatgaagaat gtgagaggct ttcaaaagtg cgagatcaac ttggacagga attggaagaa      780

ctcacagcta gtctatttga ggaagctcat aaaatggtga gagaagcaaa tatcaagcag      840

gcaacagcag aaaaacagct aaaagaagca caaggaaaaa ttgatgtact tcaagctgaa      900

gtagctgcat tgaagacact tgtattgtcc agttctccaa catcacctac gcaggagcct      960

ttgccaggtg gaaagacacc ttttaaaaag gggcatacaa gaaataaaag cacaagcagt     1020

gctatgagtg gcagtcatca ggacctcagt gtgatacagc caattgtaaa agactgcaaa     1080

gaggtaactc atcaaggact gtcccctctg actctgttga tacttgttag ttctcatcac     1140

tgaggtgtca gttatcattt ttgccagcaa aatttttagt acaaaataat gcagtattaa     1200

gatgggggag gctttatcta gagctggctg ctttcaggga ttcttcagtt ccattttcta     1260

cctggctgac cttggagtac ctgctggaaa cttggtaagt ttcttaatct cagtatttca     1320

ttaagggagg aaactgtcat gtgttgtcta gaggagagtg ggtggcttta atgatctggc     1380

tagtcaaaat ttattgctag agtgcgctta caaagtatgg atataagaaa tatgtgaaaa     1440

taagatgatt ttcttaaaga tcaatacatt gcttttattt aaattcagag agaattttat     1500

gtcagcaagg gagtcctaga gttaatttag ataattaagc aacaaaaaaa tagaaataat     1560

ggtagcctta caatgacata aggctggaag acattttgct aagtgaaatt tcaagttata     1620

gtagaacaat tagtgtcatt tttgatccca aattaggttt cacagttcag ccagtctgtt     1680

attcagacac ttacaactat gtaaggccac cattatcatg tatccataac aattaaaaat     1740

ttaaaaacga aataatgggc cgggcatggt ggctcatgcc tgtaatctca gcactttggg     1800

aggccaaggc cggaggatca cctgaggttg ggagttcgag accagcctga ccaacatgga     1860

gaaaccctat ctgtactaaa aatataaaat tagctgggca tggtatctca tgcttataat     1920

cccagctact caggaggctg aggcaggaga atcccttgaa cctgggaggc ggaggttgcg     1980

gtcagctgag attgcgccat cacactccag cctgggcaac aagagcgaaa ctctgtctca     2040

aaatcataat aataataata gtcttatttt aaaagatatg ttacaaagat aactgaaata     2100

atatataaat attttgagct gtttagagta aaaattttta atcattgtat actgtgagaa     2160

tgcatttcta agaggattga tcaataattt atgaagcttt cccatttctt cttagaagcc     2220

atcttttaca ttgttaaatt caagtccatc attaatcttg aagaaatgtg tgtgcttgtt     2280

aaatttttgt atggaagcca ggagtttatt aaatggaata accaatgtta acctgtttta     2340

attgaattgc attttgacga attatcaata aaaatgatgc tggtaa                    2386


<210> 2052
<211> 1578
<212> DNA
<213> Homo sapiens

<400> 2052
cccgccgcct ctgcgcccgc gccgcgcccc cggcgccccc tccccagcgc gcccccggcc       60

gctcctccgc gccgcgctcg tcggccatgg cccgggagaa cggcgagagc agctcctcct      120

ggaaaaagca agctgaagac atcaagaaga tcttcgagtt caaagagacc ctcggaaccg      180

gggccttttc cgaagtggtt ttagctgaag agaaggcaac tggcaagctc tttgctgtga      240

agtgtatccc taagaaggcg ctgaagggca aggaaagcag catagagaat gagatagccg      300

tcctgagaaa gattaagcat gaaaatattg ttgccctgga agacatttat gaaagcccaa      360

atcacctgta cttggtcatg cagctggtgt ccggtggaga gctgtttgac cggatagtgg      420

agaaggggtt ttatacagag aaggatgcca gcactctgat ccgccaagtc ttggacgccg      480

tgtactatct ccacagaatg ggcatcgtcc acagagacct caagcccgaa aatctcttgt      540

actacagtca agatgaggag tccaaaataa tgatcagtga ctttggattg tcaaaaatgg      600

agggcaaagg agatgtgatg tccactgcct gtggaactcc aggctatgtc gctcctgaag      660

tcctcgccca gaaaccttac agcaaagccg ttgactgctg gtccatcgga gtgattgcct      720

acatcttgct ctgcggctac cctccttttt atgatgaaaa tgactccaag ctctttgagc      780

agatcctcaa ggcggaatat gagtttgact ctccctactg ggatgacatc tccgactctg      840

caaaagactt cattcggaac ctgatggaga aggacccgaa taaaagatac acgtgtgagc      900

aggcagctcg gcacccatgg atcgctggtg acacagccct caacaaaaac atccacgagt      960

ccgtcagcgc ccagatccgg aaaaactttg ccaagagcaa atggagacaa gcatttaatg     1020

ccacggccgt cgtcagacat atgagaaaac tacacctcgg cagcagcctg gacagttcaa     1080

atgcaagtgt ttcgagcagc ctcagtttgg ccagccaaaa agactgtgcg tatgtagcaa     1140

aaccagaatc cctcagctga cactgaagac gagcctgggg tggagaggag ggagccggca     1200

tctgccgagc acctcctgtt tgccaggcgc tttctatact taatcccatg tcatgcgacc     1260

ctaggacttt ttttaacatg taatcactgg gctgggtgca gtggctcacg cctgtaatcc     1320

caacactttg ggaggctgag gcaggaggac tgtttgagtt caggagtttt aagaccagcc     1380

tgaccaacat ggtgaaaccc catctctact aaaatataaa aattagccgg gtgtggtggc     1440

gagcacctgt aatgtcagct acttgggagg ctgaggcagg agaatcactt gaacccagga     1500

agcggaggtt gcaatgagct gagatcacac cactgcactc cagcctgggt gacagattga     1560

gactccctct caaaaaaa                                                   1578


<210> 2053
<211> 8154
<212> DNA
<213> Homo sapiens

<400> 2053
ggaggaggcg cgaggtgggg gggagcgcgg cgggcggcag ggagggagcg ggagggaggc       60

aagaaagtag cagaaagtga ggctggcagg cggcggcaaa ggagccggcg cgcggcggcg      120

gcaggaagtc tgtgcccgag aacagcagaa ataagagcca gggagggacc gcggccgcgg      180

cggcggcggc gagagcgaaa gaggaaactg cagaggagga agctgcgccg cagcccgagc      240

cgcccggcat ccccgccgcc tctgcgcccg cgccgcgccc ccggcgcccc ctccccagcg      300

cgcccccggc cgctcctccg cgccgcgctc gtcggccatg gcccgggaga acggcgagag      360

cagctcctcc tggaaaaagc aagctgaaga catcaagaag atcttcgagt tcaaagagac      420

cctcggaacc ggggcctttt ccgaagtggt tttagctgaa gagaaggcaa ctggcaagct      480

ctttgctgtg aagtgtatcc ctaagaaggc gctgaagggc aaggaaagca gcatagagaa      540

tgagatagcc gtcctgagaa agattaagca tgaaaatatt gttgccctgg aagacattta      600

tgaaagccca aatcacctgt acttggtcat gcagctggtg tccggtggag agctgtttga      660

ccggatagtg gagaaggggt tttatacaga gaaggatgcc agcactctga tccgccaagt      720

cttggacgcc gtgtactatc tccacagaat gggcatcgtc cacagagacc tcaagcccga      780

aaatctcttg tactacagtc aagatgagga gtccaaaata atgatcagtg actttggatt      840

gtcaaaaatg gagggcaaag gagatgtgat gtccactgcc tgtggaactc caggctatgt      900

cgctcctgaa gtcctcgccc agaaacctta cagcaaagcc gttgactgct ggtccatcgg      960

agtgattgcc tacatcttgc tctgcggcta ccctcctttt tatgatgaaa atgactccaa     1020

gctctttgag cagatcctca aggcggaata tgagtttgac tctccctact gggatgacat     1080

ctccgactct gcaaaagact tcattcggaa cctgatggag aaggacccga ataaaagata     1140

cacgtgtgag caggcagctc ggcacccatg gatcgctggt gacacagccc tcaacaaaaa     1200

catccacgag tccgtcagcg cccagatccg gaaaaacttt gccaagagca aatggagaca     1260

agcatttaat gccacggccg tcgtcagaca tatgagaaaa ctacacctcg gcagcagcct     1320

ggacagttca aatgcaagtg tttcgagcag cctcagtttg gccagccaaa aagactgtct     1380

ggcaccttcc acgctctgta gtttcatttc ttcttcgtcg ggggtctcag gagttggagc     1440

cgagcggaga cccaggccca ccactgtgac ggcagtgcac tctggaagca agtgactggc     1500

cctggaggtg gggcccgggg tcggggctgg ggaaggggag ccccagggtc gccagagccg     1560

cgagccactc cagcgagacc ccaccttgca tggtgcccct tcctgcatag gactggaaga     1620

ccgaagtttt tttatggcca tattttctac tgcaattctg aagtgttcat ttctcacaaa     1680

ctgtactgac tcgaggggcg ctgatttcat aggatctggt gctgtatata cgaatcttgc     1740

aaagctctaa ctgaacggac cttcttattc ctctccccta acaccatcgt ttccactctt     1800

ctcagtgtag gtaaccgtct atggtgtgtt ttttcattaa tgacaaaaaa aaaaaggttt     1860

caactggatt atttaaatat tggtaaatat tgtgcattag ggtttgtttt tccttttaag     1920

aagtatgtcc tttgtatctc taagttacat gacctatatc ttttcctctt taatagtagt     1980

tttatgttaa cctttaagag atttgttttt cctcaaagga gaatttaaag gtatttttta     2040

aaattctaat aagaggatca gccgggtgca atgactcatg cctgtaatcc cagcacgttg     2100

ggaggccaag tcgggcggat cacaaggtca ggagatcaag gccatcctgg ccaacatggt     2160

gaaaccccac gtctactaaa aatacaaaaa attagccggg cgtggtggca cacacctgta     2220

gtcccggcta ctcgggaggc tgaggcagga gaattgcttg aacccgggag acggaggttg     2280

cagtgagctg agatcgtgcc actgcactcc agcctgggtg acagagcaag actctgtctc     2340

aaaaaaaaaa aaaaaaattc taacaagagg atcatgaatc tgtctccaag gctaagagtg     2400

cccttcacct ctactccttc tgtttctctc cccttcccca ggaggagggg cccctcagtt     2460

ctgcgaggct ctcttctctg cgggggactt tggtagagaa tctgcacaga gcctttgctg     2520

gcaacccatc cagcagaacc cacacccacc agagacccta gaggcctctt gccatcagca     2580

accagaaata agcctgctcc cccgagacgc agggctcagc ttcacaggcc agacttgctg     2640

tgagtgagat gcccacactg cagagatgca ggaccctccc ttgcaaaagg aaccagctgc     2700

catgttgctg aaagtgggcc cacacacaac cctcatttct cacgagagct aacagatgaa     2760

agctcagcta tgcagtgtta aaattcatct ctttctctgt ggtttttaaa aaaatgcatt     2820

tctaatctta cacttcacgt ggcctccaac acaaagttct ttctccacat ttttaccctc     2880

ttctcacatg aatgttttcc aagggaagga agggagggaa gcagccttgg gaaaggatcc     2940

atttctggtg gtaaggagag ggggccctgc caggctaatg ggacttcagc caccacagag     3000

atgaccaaag accacctccg ccaggcccag ccagtgcttg cagccctccc attggtcagg     3060

ggagtctaaa atcaaagata catggtggta gggtcaccaa acgtcccatt tgcccgagac     3120

tgaaggattt ctcaggctgt ggacatttaa tgccaaaacc aggaatatcc ggggcaaagc     3180

aggctgtgtt gttcgccttt gtggagccag gcagtgtgtg gcccagggaa agctgcgttt     3240

catggaggct tccaggaggc tgccctgtaa agccaggcag gtggcttcaa gtgccattcc     3300

tgcaagtgcc cctgcttcag ctctcaggcc catccaatgc ctcgagccca cgggggtgtc     3360

ccggcaggtc tgcgtcatca cgacccagta acgctgctgg ctgtgtcctc atgccctctt     3420

cctctggctg gccagtcatg ggaagtcctg ttggttgagt catctttgtc acttctacac     3480

ctttgagtat gtacaggctg aatgttgagt gatgcccccc caccctctca ataaacacac     3540

acacacacac acacacacac acacacacac acaatgttat taggcacagc agctccatcc     3600

tgctccctga gaatggcagt gcaggcacag agaagagcag ttgggaagac aggcagctgg     3660

tctaccctgt ccccgcacac ttcacaggca ctccactgct tggcaggaat tctgcatggc     3720

atctgccacg catgctcaca gggtgaaaaa tcaagctgtc actctgcaaa atctaaaaac     3780

cctggaaagg tctataagat gacattagac ccagttaaga agcaagtgtc acctgagttg     3840

gccatgcaat gaatgaatat tataagcagt attggagaac taggcggttg cttactaaga     3900

agtgtcttgg aaacattcga gttcatacag tgcatgacaa agtaatagaa ggctgcaagc     3960

gctgaaaatg cacccgaatc tggtacctag gatgagtaca tgaatagtga tgaatagccc     4020

tttgtgctgt gtgctatata caaccatttg cattcagaaa gcagcatttg aagctgagtt     4080

ccattactgg tgattgaagt attttcagga gcagatacat gtggtgcatg ttatatgcac     4140

ttagtttgaa agtatccctc acccaaaaag tgcagaacct ctgaaaggtg agccgtggtg     4200

caggtgcccc cctcgctgtt cgggtcagtt cttggccatg cttggcctgt cacacgccgg     4260

gtctcaacaa catcgtgcga ggagacagtg actggtttca gcccaagagt caactgttga     4320

gcatgacatc aggaagcctg tactgtcctg atcccaccag gcttgggtta atttcctatt     4380

gcttcagaga aagagaggcg ctcttgtgct tttgagagag ctctcatgtt aaaaagaggt     4440

tgtctttgca ctgcgcttgg tatgatttgt tttcttataa aacaggaaga gaacctagaa     4500

tgtgcctttc gtgaaggtct gacaaatggg gtctcagagt cctaggaccc gcaccaaggt     4560

cagagtccac ctgtagaggc tgagcatttc tacatgcacc cagggtgctg ggctgaggct     4620

aagggtggac gcgtagaccc catcacaggc ttccttcctg agcccaagtc ccccatttgg     4680

tcactatccc ttctcagagc aagtggattc tcttttcctc acttggagta ttcaatgttg     4740

aagtagtggc ctggagtggc ctttccctca gctgcctgtc tgggcctccc tggcttcccg     4800

gatcttcatc tcatacgtga ggcaatagga ggagtttcta ttcattgaga caaacagtga     4860

gcgggcacca acaggccagc agcttggccc ttttcacaga ggtggccttg gagtctggag     4920

tctgggcagc tgtctgcctc tctacggctc tgcttcccag cgggcacacg ggtccggagc     4980

ctcagaatga agtggtgcag aggcgcaggg cacacctagg agaagctcaa tgaccaccaa     5040

agcccttgag gagagacggg gtttgctgtg ttagagaaat ggcaaccccc aggaccatgc     5100

acggctctgg cagtgcacag tggctgattt tcaccagttc ctcctacccc tgcctctgtc     5160

ggagactaga aaacattcta ccccttcagg tcttctttta aaagaaaaga gctatggcaa     5220

agcgtgccat acaaagttaa aaaaaggaag agtggctttg cgttcttgac catggccaca     5280

attctggtca cttctagcat ctgaccttga gaacggtgta gagtctctga gccaccgctg     5340

gcctttgaga gagtctcact ctccagctag ctctttgtgt agtgtccagg gccccggcag     5400

tcaggataga gcgagcaaaa gaagatggac agtggacagg gcgcagtggc tcacgcctgt     5460

aatcccagcg ctttgggaga gcgaggcggg cagatcacaa ggtcaagaga tcaagaccat     5520

tctggccaac atggtgaaac cctgtttcta ctaaaaatac aaaaattagc tgggcatggt     5580

ggtgcgtgcc tgtaatccca gctactcggg aggctgaggc aggagaatcg cttgaacccg     5640

ggaggcagag gttgcagtga gccgagatcg tgccactgca ctccagcctg ggtgacagag     5700

caagactccg tctcaaaaaa gatggccatg ctggccaagg ctgggctcat aggaaatatc     5760

tgtagtagga tgaaaggaat ctggcctagg gagccccgga ctcggtttac ctaccccgta     5820

ctcatcccac tcatctgtct accctagtgt ccatcatgcc ctggatgaat cgtaggtggg     5880

agggacagaa gccgagaaca ccaggcacac ggggtggggg gaatgggggg agcccaggtg     5940

atcccctttg gaaagtggat tgatcctctc ccctgtggaa tgacagctta acctgattaa     6000

cccactgggg cttgctattt tatgagcatt tttaaacaga aaggaaagat gatatcccag     6060

tgcaggtaga ctttattttt gaaagcatcg tggcccctca cctctccctc tcccccagaa     6120

ccttggccag aattgagtct tcgcgttggg gaggccacgc tggaaccatt gctctagggc     6180

tgaaggtgga agtagggcca ctgccgcagc ttcagccaga gccctcgctg cttcgcagaa     6240

tttaacaagc acacgactgg gattcctttg gatatgagaa aggaaggcaa gtgcgggcaa     6300

agggaagctc ctcccgtttt tcataaacag aagtaagatg tcctctttcc caggtttgca     6360

caatcacttc tggcaaatta attgaaggtc cttgaattca gccagtgcac gaaacctttg     6420

catgttcttc tgaaactgta cttcttccct attctgtcta cccacactct gcgaactttg     6480

ccttttcctt aaacacattc cagaccaaac actgttcagt ttgttaaaaa aaaaaaaaaa     6540

aaaaaaagat gtatatacct gtatgtgatc caccaccctt ttgaggggca cctggtcctc     6600

ggttggggct gcaggtgtgc ctgacatttg caaaagatat tccagtcttt cgatgttcag     6660

aattgaaaat gtggagatag aaaagctcaa acagactcct aaaaggaggg tttctttcct     6720

gaagactcca agaaaatgag tgtgcagatg agttagcttg acaacctcaa ctctggggag     6780

caggcaggcg gtctgaggaa gataagggcc cacgccccac tcacctggca cctgttcggt     6840

ggtcccgggg catcatggtc tgcagctctg ggcccccagc cccactgtga agtcagtcct     6900

gcatgctggc cgaggcccgg ccacctcccg atgcctccag agtcagtggg aaggagtcag     6960

cccttcccag acttccccgc cacctccagc aggagcagct cagtttgtgg ctctgggagc     7020

tccgcttttg caaacccaaa aaggctgtgc atttggaagc caaacgctca gcatgcggct     7080

gccgagtctg gttttgtgga caaagcaaac tgtggaatgg cttctcggtg tctgtataaa     7140

gggacaaacg gttgcattca ccctttgtac tataacaccg cttctgcatt cgccatatcc     7200

gttttttaac ctttttgtct ccggggaact tctcattcga ttattatgtc ttctgatgat     7260

ttgccatgtt attttaaagg tgattttatt ttcttatgga caggaaaaaa gaaaatgagg     7320

aggagttggt tttactctta gagataagac ttcagcaggg gctcagaaac cccaaactct     7380

agttaaattg cttctcggag gaaaatctta atctagacag attcagattc ccaggctctc     7440

ctggaagccc tgcacttcag ggcacagggg ccctgggacg tggttggcag ccaggctgcg     7500

agagagctaa aaaggaacaa gaacatcagc tcggatgttt gtctctcagc cctgacacct     7560

gccactctcc ttcccggggc acttggccct atcagaggga catgaaatgc tgtccgaatg     7620

gtggcagaaa tgcagcgaca ttgcatgcag cagagtcttt gcttcgaaag atggggcgcc     7680

atgtttcaga gaacatttat cttagtccca cgttcaggtg agaagacctc aaaggtaccc     7740

tctgtccaga ataaacattg gaacaatctc tcaattggct tttgtcacta cacataatgt     7800

aatctccctt ctttcagctc ccccaacagt gagcatgctt cccaaaaaat tacaacatca     7860

aaaccaggaa tgtccccgca tctactatta ccaggcttgc aattggttca attttcccat     7920

aaaaacatgt ttgtccaaaa gaagggaaac tgtgaattta ttccatgcat gtaataaact     7980

ctgcaagaag tttaacccac ataggtttgc ggcactgcaa aattgttcat gggtctatgt     8040

agcaaatgat tctctgcctt gacaatcatg tatacatatc aagatttcta tcataatgat     8100

aatgagattg atgacttcct gttttcctcc aataaagaca attaatcacc ttca           8154


<210> 2054
<211> 933
<212> DNA
<213> Homo sapiens

<400> 2054
gcagcagcgg cggcagctgg aggatgaaga aggagcatgt gcttcactgc cagttctccg       60

cgtggtaccc gttcttccga ggcgttacca tcaagagtgt cattcttcca cttcctcaga      120

atgtgaagga ttatttactc gatgatggaa ctctggtggt ttcaggaagg gatgatccac      180

caacacattc tcagccagac agtgatgatg aagcagaaga aatacagtgg tctgatgatg      240

agaacacagc cacgcttacg gcaccagaat ttcctgagtt tgccactaaa gtccaggaag      300

ctatcaattc cctcgggggc agtgtctttc ctaagcttaa ttggagtgcc ccaagggatg      360

cgtattggat agcaatgaat agttctctga aatgtaaaac cctcagcgac atctttctgc      420

ttttcaagag ttccgatttc atcactcgtg acttcactca gccgtttatt cattgtactg      480

atgattctcc agatccatgt atagaatatg agctcgttct ccgaaaatgg tgtgaattga      540

ttcctggggc tgagtttcga tgttttgtca aggaaaacaa gcttattgtt gtgttcgata      600

tatacagaga cagtaggggg aaggtgtggc tcattgactt taatccattt ggtgaagtca      660

cagattcact gctgttcacc tgggaagaac tgatatctga gaacaactta aacggcgatt      720

ttagtgaagt tgacgctcaa gagcaggatt ccccagcttt ccgttgcaca aacagtgaag      780

tgacagtcca gcccagcccc tatttgagtt accggctacc caaggacttt gtagacctct      840

ctactgggga ggacgctcac aagctaatag acttccttaa gctgaagaga aatcagcagg      900

aggacgactg atgagcgtac tggaactgga gaa                                   933


<210> 2055
<211> 3925
<212> DNA
<213> Homo sapiens

<400> 2055
aaagagcccg ctccgccgag cgccgggcga cggcaggaag cccctccgct tggccagaat       60

ggagcagccg aagggagttg attggacagt catcatcctg acctgccagt acaaggacag      120

tgtccaggtc tttcagagag aactggaagt gcggcagaag cgggagcaga tccctgctgg      180

gacgctgtta ctggccgtgg aggacccaga gaagcgtgtg ggcagcggag gagccaccct      240

caacgccctg ctggtggctg ctgaacacct gagtgcccgg gcaggcttca cttggatttg      300

tgttggagtc tctctctgga ttcgagggtg ccatcctcca gggcgtctgc ctgaggcctc      360

tgttcacagg gctttcccac tcctgcaggt ggtcacatcc gatgtcctgc actcggcctg      420

gatcctcatt ctgcacatgg gtcgagactt cccctttgat gactgtggca gggctttcac      480

ctgcctcccc gtggagaacc ccgaggcccc cgtggaagcc ttggtctgca acctggactg      540

cctgctggac atcatgacct atcggctggg cccgggctcc ccgccaggcg tgtgggtctg      600

cagcaccgac atgctgctgt ctgttcctgc aaatcctggt atcagctggg acagcttccg      660

gggagccaga gtgatcgccc tcccagggag cccggcctac gctcagaatc atggcgtcta      720

cctaactgac ccccagggcc ttgttttgga catttactac cagggcactg aggcagagat      780

tcagcggtgt gtcaggcctg atgggcgggt gccactggtc tctggggttg tcttcttctc      840

tgtggagact gccgagcgcc tcctagccac ccacgtgagc ccgcccctgg atgcctgcac      900

ctacctaggc ttggactccg gagcccggcc tgtccagctg tctctgtttt ttgacattct      960

ccactgcatg gctgagaacg tgaccaggga ggacttcctg gtggggaggc ccccagagtt     1020

ggggcaaggc gatgcagatg tagcgggtta tctgcagagc gcccgggccc agctgtggag     1080

ggagcttcgc gatcagcccc ttaccatggc ctatgtctcc agcggcagct acagctacat     1140

gacctcctca gccagtgagt tcctgctcag cctcacactc cccggggctc ctggggccca     1200

gattgtgcac tcccaggtgg aggagcagca gcttctggcg gccgggagct ctgtggtcag     1260

ctgcctgctg gagggccctg tccagctggg tcctgggagc gtcctgcagc actgccacct     1320

gcagggcccc attcacatag gcgctggctg cttggtgact ggcctggata cagcccactc     1380

caaggccctg catggccggg agctgcgtga ccttgtcctg cagggacacc acacgcggct     1440

acacggctcc ccgggccacg ccttcaccct cgttggccgt ctggacagct gggagagaca     1500

gggggcaggc acatatctca acgtgccctg gagtgaattc ttcaagagga caggtgttcg     1560

agcctgggac ctgtgggacc ctgagacgct gcccgcagag tactgccttc ccagcgcccg     1620

cctctttcct gtgctccacc cctcgaggga gctgggaccc caggacctgc tgtggatgct     1680

ggaccaccag gaggatgggg gcgaggccct gcgagcctgg cgggcctcct ggcgcctgtc     1740

ctgggagcag ctgcagccgt gcctggatcg ggctgccacg ctggcctctc gccgggacct     1800

gttcttccgc caggccctgc ataaggcgcg gcacgtgctg gaggcccggc aggacctcag     1860

cctgcgcccg ctgatctggg ctgctgtccg cgagggctgc cccgggcccc tgctggccac     1920

gctggaccag gttgcagctg gggcaggaga ccctggtgtg gcggcacggg cactggcctg     1980

tgtggcggac gtcctgggct gcatggcaga gggccgtggg ggcttgcgga gcgggccagc     2040

tgccaaccct gagtggatgc ggcccttctc atacctggag tgtggagacc tggcagcggg     2100

cgtggaggcg cttgcccagg agagggacaa gtggctaagc aggccagcct tgctggtgcg     2160

agcggcccgc cactatgagg gggctggtca gatcctgatc cgccaggctg tgatgtcagc     2220

ccagcacttt gtctccacag agcaggtgga actgccggga cctgggcagt gggtggtggc     2280

tgagtgcccg gcccgtgtgg atttctctgg gggctggagt gacacgccac cccttgccta     2340

tgagcttggc ggggctgtgc tgggcctggc tgtgcgagtg gacggccgcc ggcccatcgg     2400

agccagggca cgccgcatcc cggagcctga gctgtggctg gcggtggggc ctcggcagga     2460

tgagatgact gtgaagatag tgtgccggtg cctggctgac ctgcgggact actgccagcc     2520

tcatgcccca ggggccctgc tgaaggcggc cttcatctgt gcagggatcg tgcatgtcca     2580

ctcggaactc cagctgagca ccagcagcat cctggcaggc actgccctgg ctgccttgca     2640

gcgagccgca ggccgggtgg tgggcacgga agccctgatc cacgcagtgc tgcacctgga     2700

gcaggtgctc accactggag gtggctggca ggaccaagta ggtggcctaa tgcctggcat     2760

caaggtgggg cgctcccggg ctcagctgcc actgaaggtg gaggtagaag aggtcacggt     2820

gcctgagggc tttgtccaga agctcaatga ccacctgctc ttggtgtaca ctggcaagac     2880

ccgcctggct cggaacctgc tgcaggatgt gctgaggagc tggtatgccc gacttcctgc     2940

tgtggtgcag aatgcccaca gcctggtacg gcaaactgag gagtgtgctg aaggcttccg     3000

ccaaggaagc ctgcctctgc tgggccagtg cctgacctcg tactgggagc agaagaagct     3060

catggctcca ggctgtgagc ccctgactgt gcggcgtatg atggatgtcc tggcccccca     3120

cgtgcatggc cagagcctgg ctggggcagg cggtggaggc tttctctatc tgttgaccaa     3180

ggagccacag caaaaggagg ccttggaggc ggtgctggcc aagaccgagg gccttgggaa     3240

ttacagcatc cacctggttg aagtggacac tcagggcctg agcctgaagc tgctggggac     3300

cgaggcctca acctgttgcc ctttcccatg aagctggctt ctctctgcaa caggagaaaa     3360

cctggagcta cagtgtcccc caccttcctt gccccatggg aacctccacc tcctactccc     3420

cacccacctc tgcgaatctg ctcccaaagg aagctgacca gagcaagatc tgggcaagca     3480

gagagtgcct gggacaggac tgtgacctgg tggacagggg cctagatgta gcctctgttc     3540

ctcctggaca taggaaggtc ccaagcttag tatcccacgt ggcctttaca aatcctatgg     3600

ctggccttct cattccacaa gggccctgga aagggttgac agccagcctt ggcatatggc     3660

tgggagtccc ttagcaaggc caaccctgaa gaggcccttt gaggcattcc ctatggctta     3720

gagttgtaga cttacactca accctcatgt gagcgtggga gtgagggtgg cggtcccttg     3780

ccaagttggt agcagtgacc cagtgattca ctgccatccc aggccttaac tagcaaaact     3840

acggagcgtg ccaagtgacc tggtgcctgt gggaagtggg ttctcaggac tggcattctt     3900

ggaataaatt cactctgtcc ttgca                                           3925


<210> 2056
<211> 475
<212> DNA
<213> Homo sapiens

<400> 2056
gtccctgctc atgcttgagc tggcccagga ccgcttgcag ttcgagactg tggaagtctc       60

ggagcccagc atgctgcaga agatcctcac caccaggcgg cgggagaccg ggggcaacga      120

gccactgccc gtgcccacgc tgcagcacca tttggcaccg ccggcggagg ccaggaaggt      180

gccctccgcc tcccaggtcc aagccatcaa gtgctttctt tccaaatgct ggagtctgaa      240

catcagtacc aaggagtacg cctacctcaa ggggaccgtg ctctttaacc cgggaaaagg      300

gaaggaaaat gattgcaatc atcattaaca tcatttaaac caagtggtca actgctaatt      360

acttgaatac aagttaaaga actttgcaac gatattatca tcatggaaga tcaaaggacc      420

ttcaaaagca gcctcctctt attactttcc ttataaaaac ttacatccac ttaaa           475


<210> 2057
<211> 2021
<212> DNA
<213> Homo sapiens

<400> 2057
gagctcccac gctgctgttc ttccatttcc agcttttaaa gagcacccgc cccttcgaac       60

caccgaggtc atgggcgaac acaccggagc gcagcaccgc gcccccccgc acacaccgcc      120

cgcctccgcg cccttgccca gaccgaggcg gccgacgcgc ctgcgtgcgc gctaggtata      180

aataggtccc aggaggcagc cactgggcag aactgggcta cgggcgccgc gggccatggc      240

gggcgagaac caccagtggc agggcagcat cctctacaac atgcttatga gcgcgaagca      300

aacgcgcgcg gctcctgagg ctccagagac gcggctggtg gatcagtgct ggggctgttc      360

gtgcggcgat gagcccgggg tgggcagaga ggggctgctg ggcgggcgga acgtggcgct      420

cctgtaccgc tgctgctttt gcggtaaaga ccacccacgg cagggcagca tcctctacag      480

catgctgacg agcgcaaagc aaacgtacgc ggcaccgaag gcgcccgagg cgacgctggg      540

tccgtgctgg ggctgttcgt gcggctctga tcccggggtg ggcagagcgg ggcttccggg      600

tgggcggccc gtggcactcc tgtaccgctg ctgcttttgt ggtgaagacc acccgcggca      660

gggcagcatc ctctacagct tgctcactag ctcaaagcaa acgcacgtgg ctccggcagc      720

gcccgaggca cggccagggg gcgcgtggtg ggaccgctcc tacttcgcgc agaggccagg      780

gggtaaagag gcgctaccag gcgggcgggc cacggcgctt ctgtaccgct gctgcttttg      840

cggtgaagac cacccgcagc agggcagcac cctctactgc gtgcccacga gcacaaatca      900

agcgcaggcg gctccggagg agcggccgag ggccccctgg tgggacacct cctctggtgc      960

gctgcggccg gtggcgctca agagtccaca ggtggtctgc gaggcagcct cagcgggcct     1020

gttgaagacg ctgcgcttcg tcaagtactt gccctgcttc caggtgctgc ccctggacca     1080

gcagctggtg ctggtgcgca actgctgggc gtccctgctc atgcttgagc tggcccagga     1140

ccgcttgcag ttcgagactg tggaagtctc ggagcccagc atgctgcaga agatcctcac     1200

caccaggcgg cgggagaccg ggggcaacga gccactgccc gtgcccacgc tgcagcacca     1260

tttggcaccg ccggcggagg ccaggaaggt gccctccgcc tcccaggtcc aagccatcaa     1320

gtgctttctt tccaaatgct ggagtctgaa catcagtacc aaggagtacg cctacctcaa     1380

ggggaccgtg ctctttaacc cggacgtgcc gggcctgcag tgcgtgaagt acattcaggg     1440

actccagtgg ggaactcagc aaatactcag tgaacacacc aggatgacgc accaagggcc     1500

ccatgacaga ttcatcgaac ttaatagtac ccttttcctg ctgagattca tcaatgccaa     1560

tgtcattgct gaactgttct tcaggcccat catcggcaca gtcagcatgg atgatatgat     1620

gctggaaatg ctctgtacaa agatataaag tcatgtgggc cacacaagtg cagtagtgca     1680

gttcaccatg agggaagaat aaagagctgt gggcaaaaga gtgtaaaata ttttaaaata     1740

aactttctta atatttttac atgcagagta tttttgtatt caattaaaga aataatttta     1800

ttccagacag tcacaaattt ctctgttcca tagttaaaga agacatttgc caacaggtag     1860

catagctctg tacatctttt aaaaaaaaaa tagcagggta ctagtataat aagctatttt     1920

cacaagtgta gcaatttcat ggaacctgct caaatcaaat ttgtacatat tgttataata     1980

aattttaagg tcttaactat taacttgatt gaaaaaagct t                         2021


<210> 2058
<211> 7032
<212> DNA
<213> Homo sapiens

<400> 2058
atgttgcgag ccacagctcc ctgctggttc ccccctggat acccagaagc taagaaggtg       60

gccgaggagg cggccctgga ggcaagccgc catttgggag gggagcagag ccaggccggt      120

gctcccgaag gcagcaagat gttgcgagcc acagctccct gctggttccg ccctggatac      180

ccagaagcta agaaggtggc caaggaggcg gccccggagg caagccgcca tttgggagcg      240

gagcagagcc cggccggtgc tcccgaaggc agcaagatgt tgcgagccac agctccctgc      300

tggttcccac ctggataccc agaagctaag aaggtggccg aggaggcggc cctcgaggct      360

ccagaattcc cactgccctc tcatcagcct gcccagagct tcgggctctg ggtgccccag      420

atgcacaagc aggcctcagc atttgtggac atccaggcgg agccccaaaa caggggtccg      480

gcggtgcccc cagcgtggcc caagatggtg acggagtcgt gctacttccc tgcgcagagg      540

ggatcggcct gccgcttgcc agccgcccca aggctgacag agaggccctc gggagtccgc      600

atctcagccc ccaggaagag gaagacgatc gcccactctt ccagcccttg cttggtcaca      660

ggttacacag atgccaagag aacccgggtg gccagcagca gccaacgctc ccgtggctcc      720

aaggtcggca gacagccagg gaagacgcgc aacaggtcag ggatggcatg caagaccacc      780

gccaccacca gctctaagcg aatcgtccgt cgtgcatcct taccgagttt gagtttgaag      840

aaacccatta tcctccgaag ctctgggtgc caagtcccca ccgtcctccg ccgaggctat      900

ctccaactgt tcaccgaaga gtgtctcaag ttctgcgcct ccaagcagga ggccgaggag      960

aaggcgctga acgaggagaa ggtggcctac gactgcagcc ccaacaagaa caggtacctg     1020

aacgtggtcc tgaacaccct caagagactg aagggcctga cccccagctc catgcccggc     1080

ctcagcaggg ccgccctgta cagccgcctc caggagttcc tgctcaccca ggaccagctc     1140

aaggagaacg gctacccctt cccgcacccc gagcggcccg gaggcgccgt cctcttcact     1200

ggccagggga aggggcccgg cgactcctcc tgtagggtct gctgccgttg tggcaccgag     1260

tacctggtgt cctcctcggg ccgctgtgta cgcgaccagt tgtgttatta tcactggggg     1320

cgggtccgct cgagccaggt ggctggaggc cgggttagcc agtacacctg ctgtgcagct     1380

gctcctggct ctgtgggctg ccaggtggca aagcagcacg tgcgggacgg ccgcaaggag     1440

agcctcgatg gcttcgtgga gaccttcaag aaagagttgt ccagagacgc ttatccagga     1500

atctacgcct tggactgtga gatgtgctac accacgcatg gcctagagct gacccgcgtc     1560

accgtggtgg acgccgacat gcgagtggtg tacgacacct tcgtcaagcc cgacaacgag     1620

atcgtggact acaacaccag gttttccgga gtcaccgagg ccgacgtcgc caagacgagc     1680

atcacgttgc cccaagtcca agccatcctg ctgagctttt tcagcgccca aaccatcctc     1740

atcgggcaca gcctggagag cgacctgctg gccctgaagc tcatccacag caccgtggtg     1800

gacacggccg tgctcttccc gcactacctg ggtttcccct acaagcgctc cctcaggaat     1860

ctcgcggccg actacctggc acagatcatc caggacagcc aggacggcca caactccagc     1920

gaggacgcaa gcgcctgcct gcagctggtg atgtggaagg tccgacagcg cgcccagatc     1980

cagccacgcc accggtccgc ctctcccgcc gccctggcct gtccttagcc ccaggcctct     2040

tccaaaaccg ccatcagtcc cgagagctca ccctgcccac ctcgccgcaa agcgaaagaa     2100

actggagcag ccggcggcag gagagggcaa aaagccaaga gtaaccccaa ccccccactc     2160

ccggtccccc ggaatccctg ccgcggcccc tcgggcctgt ccacatccct ctgcccctcc     2220

cagacctctg tccttccacc aatcgcctcc cgcagccccg agccgccact cccagtcccc     2280

cgagtccctg ccgcgcgccc tcgcgcctgt tcacatccct ctgcccatcc gagacctctg     2340

tctttacacc actagccacc ccacgtggga cttccatggc ttctgagtac aaggccagcc     2400

ccccggccca ccagctttcg gaatgcctgc ttacctcttt ttctgtagag gcaccacagg     2460

gaggtgggtg aagcacttcg gctctggagt tacagatctg ggttcaaggc caaattccac     2520

cacttactag gtttgtaata ttggacagat aacgtctttg cgcttctacc ttttggtctt     2580

taaagtgtga tcaaaagaga cttagactcc cacatagtaa taataataat aatggcaaac     2640

ttaacacccc actgtcaaca ttagacacac caacgagaca gaaagttaaa aaaggatatc     2700

cgggaattga actcagctct gcaccaagcg gacctaggag acatgtacag aacgctccac     2760

cccaaatcaa cagaatatac attcttctca gcaccacatc acacttattt ccacattgac     2820

cacatagttg gaagtaaagc actcctcagt aaaagtaaaa taacagaaat tattacaaac     2880

ggtctctcag accacattgc aatcaaacta gacctcagga ttgagaaact cactcaaaac     2940

cgctcaactg catggaaacc gtacaagctg ctcctgaatg agtacagggt acataacgaa     3000

atgaaggcag aaataaagat attctctgaa agcaatgaga acaaagacac aacataccag     3060

aatctctggg acacatttaa agcagtgtgt agagggaaat ttatagcact aaatgcccac     3120

aagggaaagc aggaaagatc aaaaatgcat accctaacat caccattaaa agaatgagag     3180

aagcaagggc aaacacattc aaaagctagc agaaggcaag aaataactaa gatctgagca     3240

ggactgaagg agatagagac acaaaaaacg tgggatggtt ttttagtatg tggaaaaatt     3300

ctttgatggt ttttccttga aaaagtgaaa cctaaatcca ctccgtttgg atgtgggacg     3360

atttgcggtt gttgcttcct aaacataaac tacgtttagg ctgatatttc agacaatgaa     3420

acctttgagt gcccgtagcg ggaagatctc ggttgctgag tgcagggaag gaggatgtaa     3480

ttccatcata tactctctct gtgcctaccg catttggaac catgcgagtg atacctattt     3540

ataaaataaa ataaaccaag cacaagtacg aacttagcaa cactatattg agttaataga     3600

acggtatctt gtatttcttc tgtccaggta tacttataaa tgcctgcagg gatttcacca     3660

cctcagggtg gagagactga atgcttgtga gggaattagg atggtggaat attggtgtta     3720

ccagggaagg gggcgggatg tttgaaaatg ctatgtttac tcgttcttgg gttccaataa     3780

aggagaaaca gggcacagga gtcggaagga ctagtggcaa tagtgatgaa aggacctcct     3840

tatcatgctg gcaatgttaa ttacccaggt gtaggaagcc atacactgag gcggaagatc     3900

gcaagtcaga gtggccggca ggcacaacct cctggcacac cagaggcagg tcttcaatac     3960

ccactggttt ccccaacagg ctgcgtaagg gaccctgagc cacagtgagt tggtcaaatg     4020

ctcctgacag tgtggagaaa ccaacagaca aaacgtgggt gcaaaagtga tgagacccca     4080

cactttacac tcgtggtgac aatgaagcta ttaagtaaca gcttctcaac ctatgctgtt     4140

tcctgttgga tgcacataat ccatttgcac tgcagacaat tttaggatgt ggtttacagt     4200

aaggtggatg gtaccttatg gcaaaaatct ctcagaaatt tatgtgtggt tttaaagtca     4260

ttccagtcct agcacgttgt gcttttcaga gacgccatag ctgtttttcc ctttgtaata     4320

tcaaagcagt aatatgttct ctggaggcct gttgggtgaa tttaatggaa tcaagttaag     4380

taggtgccag aaccattgct gttttccctc catagccctg ccacccactg taaaaaggtt     4440

gatgagatta cttaatgatt tccaattaag ttgtatttcc aaatatcatg atttccattt     4500

taatgtagtt ggtatggagc tctgtgagtg tgtgcttctt ttattatgga tcacgttcag     4560

cttcttttta tttgcctcct agtcataata gtaaaactct actcctctac tccgaggagt     4620

ccctaccacc catctcatca ctttccagcc cagcactctt catgctcatt catttaaagc     4680

attcaacatt gtgtaaatga atcttggaag gccaaagcta ctgaatttag cgaatttgtg     4740

gaggcattgc cacaaatcag ccaggtgaag tttcacacaa tcgaagactg cacaactcct     4800

agaaggcagc actatgctgc aaacccagac ggccactctt ctcacccctc gtccgtttgc     4860

tgttctggat aatgaggttc aaaagtcacc taggcaactg ccaaaatagc tgaaatggag     4920

aaagggcttc aggctggtga ctagcagagg tccacctgac ccccgtaagc tgctgaacaa     4980

gtagggctgc cagaaatgtc ccactaggga atttggtaga gacgaagaca tgctcaccgg     5040

acaagggttc ctcccaggat acgcccgagc ggaagaagcg ggctctgagc cacgcccttt     5100

caccctcctc taccccgccc tgggctggtg aaggtgcgcg ccaggatgtg gactactgag     5160

ccctgaagaa ataagtcctt ccactttgac cccatggagg attgcctgtg aggaacttaa     5220

acgagtctac cagtgtctag acacgggggc aggtctgtcc ggcacagcag ctccctcaag     5280

gaggagaaga gtgaggagaa aggaaactca agtctcacca ttctgtcctg ggagagaaga     5340

ggaggatctc atctctcatc tgtccaaaca aggcaaggag actttctctc atctttccaa     5400

gcaaggcaag gagacttttt atcattagga aacaaaaaga atttagaagg aatgaaagca     5460

gcccgtaagg tgaattccta aggactgccc attgaaactg acaaaattgc ccttgtttga     5520

tgagaggaat gagcagagca ttgatgtggt gaacaaggat ctagtgagac tttcccagca     5580

tgtttctacc aaagctttat ctaagcttct cagaacactc tcctaataag cagatgtttg     5640

gcctttcaga aagtcaacaa gcaaaatgcc ttgagtgtcc caaaacactg atgccatgat     5700

gtgggctcct gactggcctc cttttccttt gactggaccg ctgccacctc ttggtagcca     5760

tcgctttcat gatgctttgc cttggagatc atattggtga agccatgttc caactgccgc     5820

ttacaatttg tcagagggat gcgtcaggat cgtgatccct cctgtttaaa atttccactg     5880

atagctctcg tcgtaaatgc agctgatctg ggcacagtgg ttttcacagc cactgcagga     5940

ttcatcttcc acatcttctc acctcttctt gaaacaagct atacattcgt aaagagttca     6000

tttctttggg gtagtgtcct tacaagcttt tcttaaaacg tcaatgatgt cttcaatctt     6060

ccacccaagc ttcaccataa atttgatgtt tcctcttgct gcaattttcg tggaattcat     6120

gttgctctga cgggagtcct tttcagtgga tgtctcatcc ttcttagtgc ctcaaactag     6180

atctagttca gaaaggttat cagaagttag gacaagttta ttttagtgca aaccagtgga     6240

aatccatgca tagtttcttc accatgtgca ttttctatga acctttggaa gaccacctgt     6300

gttgaacatt gcccaagtcc tgggagagaa gtgggtgcgg tccgcttcct gtcctcaatt     6360

tgcccgcagc ggcggagtgc acagagcagg gaaaggcagc cccagaggga tcccgccctc     6420

cagcatgcag cagactgctg gcccagtcct ggctccaagg ggtgctgtgt gggcccaagc     6480

aagttgacca acctccctga accttaattt aatcctaggt agcccaattc cagtagccat     6540

tataggactg ccctgccggg acagttactt aactcaggaa aagcaaccta gctccaagtt     6600

tagcaaccgg gagttccagt tgattccatt agcgcacccc ctgaggcatt cccaagctgg     6660

agtctggtgg aagatgaggc tcagtgtgat tggactgaag caccaaccta tcaaggagaa     6720

gtcccaccca gtctgccctg tgcctatata aaggcgacaa gtggcggccg cagcactcat     6780

tgaagccgcc agttgggaga ggagcagagc caggccggtg ctcccgaagg cagcaagatg     6840

ttgcgagcca cagctccctg ctggttcccc cctggatacc cagaagctaa gaaggtggcc     6900

gaggaggcgg ccctggaggc aagccgccat ttgggagggg agcagagcca ggccggtgct     6960

cccgaaggca gcaagatgtt gcgagccaca gctccctgct ggttccgccc tggataccca     7020

gaagctaaga ag                                                         7032


<210> 2059
<211> 2703
<212> DNA
<213> Homo sapiens

<400> 2059
ggagagagcg aagtcaagtc tccagggccg ctggcgactt cggaagccgc gcgcccggcg       60

ctctcggccg cccccggccg ctcgcccccg ccgcgccgcc gccctcgccc ccgggctcgc      120

ccttggcccc cggcggccgc gaaagggtgc gggagacgcg gagccggagg aggaggcgca      180

gccgctgccc gagccgcagc cgcagccgga gcccgagccg cggggcgggt gcgaagatgc      240

acacgaccca gaaggacacg acgtacacca agatcttcgt cggggggctg ccctaccaca      300

ccaccgacgc cagcctgcgc aagtacttcg aggtcttcgg cgagatcgag gaggcggtgg      360

tcatcaccga ccggcagacg ggcaagtccc ggggctatgg atttgtcacc atggctgacc      420

gggctgctgc cgaaagggcc tgcaaggatc ccaatcccat cattgatggc agaaaggcca      480

acgtgaacct ggcatactta ggagcaaaac caaggatcat gcaaccaggt tttgcctttg      540

gtgttcaaca acttcatcca gcccttatac aaagaccttt cgggatacct gcccactatg      600

tctatccgca ggcttttgtg cagccgggag tggtcattcc acacgtccag ccgacagcag      660

ctgccgcctc caccacccct tacattgatt acactggagc tgcatacgca caatactcag      720

cagctgctgc tgctgccgcc gccgctgctg cctatgacca gtacccctat gcagcctctc      780

cagctgctgc aggatatgtt actgctgggg gctatggcta cgcagtccag cagccaatca      840

ccgcagcggc acctgggaca gctgccgccg ccgctgcagc agctgctgcc gctgcagcat      900

ttggccagta ccagcctcag cagctgcaga cagaccgaat gcaatagacc agccatctga      960

tcaaagttga attgttttct ctttccctcc caattttcca atttttagta gctaataaga     1020

gagttaacat tgacttaaca gctttaaaaa aaaaaacagc catgctattg tgaagcagag     1080

ttattatttt ttttatactc caggtagtgt tctagatgag aaagaggtaa gaatgagggg     1140

aatgggcaca attttggaaa tcaatcccaa agagcctgag taaatgaaag gccactacga     1200

aatgacgcca ggagtaacaa cggaacttca cttttgtaac gggattttta tttttgctct     1260

ttttatagta tcagggaagc aaactgcctt ttacaagtta gaaaatgctg tttgaatcta     1320

gttgaaccag ggaatacaga gcgagcaata tgtagcttga attacattta aaagcagatt     1380

ttttacaaac aaaatggcga aagcactgat tgtcattttt agcagtcact taaggcctat     1440

agaacttttt tcaagtcgga aggtcctgtt cttactatct caaaaatggg catcgaacaa     1500

tcaatctagg agcgtggcag tgggtaaaat ggtggacagg caccaaagct attttctcat     1560

ctgtcctgtg gatgagtgga actgtggaac aagtgatgtg gaattaatgg gtgcaacagc     1620

tgtacagaca atcaataaca cacacagttc tggaaagaac acatcacttg tgcttgtttg     1680

atgagcttgt cacattctaa tccctctccc catcctgttt caattttggg aaacttgtat     1740

ctgctggtgt cagcaattct gattctgaaa taggatcagg cttttactac aacagccttc     1800

tctttctatt tattgtgtcg actcgtggct tatgaataaa ggcaggcaaa gtttgcagaa     1860

ctgtcttaag gacatttatt ttttttccct ttttaagtaa ttttacactt tagtatctat     1920

ttcagagtca tatttaaaac tatttattag tgactacagt acatgagaca acaaggttac     1980

tgagattaca attcttcaaa ggttaatgat aatgtggttt atactgtgcc ttaatagtaa     2040

tgctatttaa gatatttatt tttaagtttt actatgctgc actctaaaga aaggaacttt     2100

agatgtgaca ctgtaaaatt atgtattcat ctcatggcat aaattattta gtaagtctag     2160

atgtagcgta ttaaatatta acctattcaa ctaaagatgt tgacttggat ttatttaaat     2220

tcatatgtgc actgtataag agagtactct tacattaaca cattttagtt tagtttttag     2280

attttttttt aaacgatata ttgctagttt catgcttcct cctctgattt tgcctgtgta     2340

gatttcattt attggtaatt cattagttta acactattat gtagttttta aatgctgctt     2400

tacatttttc ttctgaaact gcaatacttg caatttttat tcttaaacta aattgaatac     2460

tattttacac tgtattggat ttttatactt gaacaatttc atacaaggga agacaggtta     2520

gcatttttat ggactttctc cattatcact ggatttactt taagtattcc catactagac     2580

agtgttatgt aatgtagaca tgactctcct gtgcaaatta tttattcgtt gtgtatattg     2640

ctttataaca tttcagatct tctaatctat tcacttgtat taaatataat ttttaaaaac     2700

ttc                                                                   2703


<210> 2060
<211> 5440
<212> DNA
<213> Homo sapiens

<400> 2060
gggagattcg ggaccatggc acctgtgcac ggcgacgact ctctgtcaga ttcagggagt       60

tttgtatctt ctcgagcccg gcgagaaaaa aaatcaaaga aggggcgcca agaagcccta      120

gaaagactga aaaaggctaa agctggtgag aagtataaat atgaagtcga ggacttcaca      180

ggtgtttatg aagaagttga tgaagaacag tattcgaagc tggttcaggc acgccaggat      240

gatgactgga ttgtggatga tgatggtatt ggctatgtgg aagatggccg agagattttt      300

gatgatgacc ttgaagatga tgcccttgat gctgatgaga aaggaaaaga tggtaaagca      360

cgcaataaag acaagaggaa tgtaaagaag ctcgcagtga caaaaccgaa caacattaag      420

tcaatgttca ttgcttgtgc tggaaagaaa actgcagata aagctgtaga cttgtccaag      480

gatggtctgc taggtgacat tctacaggat cttaacactg agacacctca aataactcca      540

ccacctgtaa tgatactgaa gaagaaaaga tccattggag cttcaccgaa tcctttctct      600

gtgcacaccg ccacggcagt tccttcagga aaaattgctt cccctgtctc cagaaaggag      660

cctccattaa ctcctgttcc tcttaaacgt gctgaatttg ctggcgatga tgtacaggtc      720

gagagtacag aagaagagca ggagtcaggg gcaatggagt ttgaagatgg tgactttgat      780

gagcccatgg aagttgaaga ggtggacctg gagcctatgg ctgccaaggc ttgggacaaa      840

gagagtgagc cagcagagga agtgaaacaa gaggcggatt ctgggaaagg gaccgtgtcc      900

tacttaggaa gttttctccc ggatgtctct tgttgggaca ttgatcaaga aggtgatagc      960

agtttctcag tgcaagaagt tcaagtggat tccagtcacc tcccattggt aaaaggggca     1020

gatgaggaac aagtattcca cttttattgg ttggatgctt atgaggatca gtacaaccaa     1080

ccaggtgtgg tatttctgtt tgggaaagtt tggattgaat cagccgagac ccatgtgagc     1140

tgttgtgtca tggtgaaaaa tatcgagcga acgctttact tccttccccg tgaaatgaaa     1200

attgatctaa atacggggaa agaaacagga actccaattt caatgaagga tgtttatgag     1260

gaatttgatg agaaaatagc aacaaaatat aaaattatga agttcaagtc taagccagtg     1320

gaaaagaact atgcttttga gatacctgat gttccagaaa aatctgagta cttggaagtt     1380

aaatactcgg ctgaaatgcc acagcttcct caagatttga aaggagaaac tttttctcat     1440

gtatttggga ccaacacatc tagcctggaa ctgttcttga tgaacagaaa gatcaaagga     1500

ccttgttggc ttgaagtaaa aagtccacag ctcttgaatc agccagtcag ttggtgtaaa     1560

gttgaggcaa tggctttgaa accagacctg gtgaatgtaa ttaaggatgt cagtccacca     1620

ccgcttgtcg tgatggcttt cagcatgaag acaatgcaga atgcaaagaa ccatcaaaat     1680

gagattattg ctatggcagc tttggtccat cacagttttg cattggataa agcagcccca     1740

aagcctccct ttcagtcaca cttctgtgtt gtgtctaaac caaaggactg tatttttcca     1800

tatgctttca aagaagtcat tgagaaaaag aatgtgaagg ttgaggttgc tgcaacagaa     1860

agaacactgc taggtttttt ccttgcaaaa gttcacaaaa ttgatcctga tatcattgtg     1920

ggtcataata tttatgggtt tgaactggaa gtactactgc agagaattaa tgtgtgcaaa     1980

gctcctcact ggtccaagat aggtcgactg aagcgatcca acatgccaaa gcttgggggc     2040

cggagtggat ttggtgaaag aaatgctacc tgtggtcgaa tgatctgtga tgtggaaatt     2100

tcagcaaagg aattgattcg ttgtaaaagc taccatctgt ctgaacttgt tcagcagatt     2160

ctaaaaactg aaagggttgt aatcccaatg gaaaatatac aaaatatgta cagtgaatct     2220

tctcaactgt tatacctgtt ggaacacacc tggaaagatg ccaagttcat tttgcagatc     2280

atgtgtgagc taaatgttct tccattagca ttgcagatca ctaacatcgc tgggaacatt     2340

atgtccagga cgctgatggg tggacgatcc gagcgtaacg agttcttgtt gcttcatgca     2400

ttttacgaaa acaactatat tgtgcctgac aagcagattt tcagaaagcc tcagcaaaaa     2460

ctgggagatg aagatgaaga aattgatgga gataccaata aatacaagaa aggacgtaag     2520

aaagcagctt atgctggagg cttggttttg gaccccaaag ttggttttta tgataagttc     2580

attttgcttc tggacttcaa cagtctatat ccttccatca ttcaggaatt taacatttgt     2640

tttacaacag tacaaagagt tgcttcagag gcacagaaag ttacagagga tggagaacaa     2700

gaacagatcc ctgagttgcc agatccaagc ttagaaatgg gcattttgcc cagagagatc     2760

cggaaactgg tagaacggag aaaacaagtc aaacagctaa tgaaacagca agacttaaat     2820

ccagacctta ttcttcagta tgacattcga cagaaggctt tgaagctcac agcgaacagt     2880

atgtatggtt gcctgggatt ttcctatagc agattttacg ccaaaccact ggctgccttg     2940

gtgacataca aaggaaggga gattttgatg catacgaaag agatggtaca aaagatgaat     3000

cttgaagtta tttatggaga tacagattca attatgataa acaccaatag caccaatctg     3060

gaagaagtat ttaagttggg aaacaaggta aaaagtgaag tgaataagtt gtacaaactg     3120

cttgaaatag acattgatgg ggttttcaag tctctgctac tgctgaaaaa aaagaagtac     3180

gctgctctgg ttgttgagcc aacgtcggat gggaattatg tcaccaaaca ggagctcaaa     3240

ggattagata tagttagaag agattggtgt gatcttgcta aagacactgg aaactttgtg     3300

attggccaga ttctttctga tcaaagccgg gacactatag tggaaaacat tcagaagagg     3360

ctgatagaaa ttggagaaaa tgtgctaaat ggcagtgtcc cagtgagcca gtttgaaatt     3420

aacaaggcat tgacaaagga tccccaggat taccctgata aaaaaagcct acctcatgta     3480

catgttgccc tctggataaa ttctcaagga ggcagaaagg tgaaagctgg agatactgtg     3540

tcatatgtca tctgtcagga tggatcaaac ctcactgcaa gtcagagggc ctatgcgcct     3600

gagcagctgc agaaacagga taatctaacc attgacaccc agtactacct ggcccagcag     3660

atccacccag tcgtggctcg gatctgtgaa ccaatagacg gaattgatgc tgtcctcatt     3720

gcaacgtggt tgggacttga ccccacccaa tttagagttc atcattatca taaagatgaa     3780

gagaatgatg ctctacttgg tggcccagca cagctcactg atgaagagaa atacagggac     3840

tgtgaaagat tcaaatgtcc atgccctaca tgtggaactg agaatattta tgataatgtc     3900

tttgatggtt cgggaacaga tatggagccc agcttgtatc gttgcagtaa catcgattgt     3960

aaggcttcac ctctgacctt tacagtacaa ctgagcaaca aattgatcat ggacattaga     4020

cgtttcatta aaaagtacta tgatggctgg ttgatatgtg aagagccaac ctgtcgcaat     4080

cgaactcgtc accttcccct tcaattctcc cgaactgggc ctctttgccc agcctgcatg     4140

aaagctacac ttcaaccaga gtattctgac aagtccctgt acacccagct gtgcttttac     4200

cggtacattt ttgatgcgga gtgtgcactg gagaaactta ctaccgatca tgagaaagat     4260

aaattgaaga agcaattttt tacccccaaa gttctgcagg actacagaaa actcaagaac     4320

acagcagagc aattcttgtc ccgaagtggc tactccgaag tgaatctgag caaactcttc     4380

gctggttgtg ccgtgaaatc ctaagggaat cccaggagta accaaggagg gggtagttga     4440

aaaatcccag cttcctctgt gcctccactc tggccctaaa tgctcctcca gcatctgttt     4500

ctcccttggg actgtgtctc atgtttgtgt gaatgtagac caggaaaggg ggctgcaaaa     4560

atgttgagtc taatgttcgt aagcatcata gaaattcctg tcttcatatt aagatgtact     4620

gctttaaaac acaactccag agcccctccc caagctcccc tccccaagct cctgaagacc     4680

cggtttctga gggagggaaa ttgctacttg gattgagagt agctggaatg taagtgaccc     4740

caggctttgc ctcagggcct ttagcctatg tcccccccac ataaagagag cttctcagag     4800

cctgactgaa gagctgacgt tttgcttttt catatgccaa ttaaacccgg tctaaatcca     4860

aatgcttctc cagccatcca ggagtggctg tccttttcag tcttgtcttt tatataggta     4920

gctgaggggg aagatttaga agccttgcac tcactaaata gattaaacag agcaggcttg     4980

tttgttgaat tgctccaaag tccaacagac acacactgag caggtgtttt acactcacat     5040

tccctttttg ccccttaaat agaaagtgca ggtaaaggtt tatacaacaa gaaagcacat     5100

tgaaaataat ttgatactct aacaatccat taacatgtgt aggggttacg gtgaggatca     5160

ctgtgttgta ttcagaaaaa cggggagagg gatgcttaat tggccctggc gcttgctatt     5220

tttttctcat ttcttcacaa taggaccgtc tttggcagca gcaaaatgta tttcagtatg     5280

gcagtctttc ctctcttaca ttattggtaa gattatacta acaaaatgtt tccccttgta     5340

caattatgct gtgtttttaa aaaacattga cctgtgtgtt tttataaaag aaaaagtatg     5400

ttgtgccttc ttcttaagaa taaagttttc taaagggaaa                           5440


<210> 2061
<211> 6111
<212> DNA
<213> Homo sapiens

<400> 2061
ctttgtggtc tacagccaca ccaccccaaa tgtgcctgat cttgtctgat cttggaagct       60

aagcattgtt gggcctagtt aggacctgga taggagaaat cccttatggc taactatatg      120

tcagaaagca tcagcttttc tcgatggacc cattcatcta atgaaatatg cctgtactat      180

tttaaaaagc tttgtatttc gtcatagaaa agttcatccc cccagaatga aaatgaggac      240

atttgagaag gtgatttaag gtgtggacat ttgagaaggt gtcctatcaa attagtaaac      300

caaaggaaaa gtactgaata gattaatcca aaacacttac tgttttttaa acgaagagga      360

tttcaccttg acagaaaaac aacttttatt caatatgtat ttcctgaaat taaagagaca      420

agtacagact gaaaggaaaa tagattcgta aataagctac gtcaactcta tcctgctgag      480

gatagctcag tgatgttaaa tcctttacaa atccctggtt gtcttcctac agacaagact      540

gctttttgat gggactgata ttaagagaaa taggaccttt ggggcattca actccttgat      600

aaaacttaaa agtatcggca tgagtggctt aacagaggaa ataaagaagt tttcaactaa      660

atccaaaagt gcggtcattt tctttactgc tgttatttta aaaacctctt cataaccatt      720

gaaaaagaat cgacaactat tttaaaagat taaagaaagg cagatgtctg caaataattc      780

ccctccatca gcccagaagt ctgtattacc cacagctatt cctgctgtgc ttccagctgc      840

ttctccgtgt tcaagtccta agacgggact ctctgcccga ctctctaatg gaagcttcag      900

tgcaccatca ctcaccaact ccagaggctc agtgcataca gtttcatttc tactgcaaat      960

tggcctcaca cgggagagtg ttaccattga agcccaggaa ctgtctttat ctgctgtcaa     1020

ggatcttgtg tgctccatag tttatcaaaa gtttccagag tgtggattct ttggcatgta     1080

tgacaaaatt cttctctttc gccatgacat gaactcagaa aacattttgc agctgattac     1140

ctcagcagat gaaatacatg aaggagacct agtggaagtg gttctttcag ctttagccac     1200

agtagaagac ttccagattc gtccacatac tctctatgta cattcttaca aagctcctac     1260

tttctgtgat tactgtggtg agatgctctg gggattggta cgtcaaggac tgaaatgtga     1320

aggctgtgga ttaaattacc ataaacgatg tgccttcaag attccaaata actgtagtgg     1380

agtaagaaag agacgtctgt caaatgtatc tttaccagga cccggcctct cagttccaag     1440

acccctacag cctgaatatg tagcccttcc cagtgaagag tcacatgtcc accaggaacc     1500

aagtaagaga attccttctt ggagtggtcg cccaatctgg atggaaaaga tggtaatgtg     1560

cagagtgaaa gttccacaca catttgctgt tcactcttac acccgtccca cgatatgtca     1620

gtactgcaag cggttactga aaggcctctt tcgccaagga atgcagtgta aagattgcaa     1680

attcaactgc cataaacgct gtgcatcaaa agtaccaaga gactgccttg gagaggttac     1740

tttcaatgga gaaccttcca gtctgggaac agatacagat ataccaatgg atattgacaa     1800

taatgacata aatagtgata gtagtcgggg tttggatgac acagaagagc catcaccccc     1860

agaagataag atgttcttct tggatccatc tgatctcgat gtggaaagag atgaagaagc     1920

cgttaaaaca atcagtccat caacaagcaa taatattccg ctaatgaggg ttgtacaatc     1980

catcaagcac acaaagagga agagcagcac aatggtgaag gaagggtgga tggtccatta     2040

caccagcagg gataacctga gaaagaggca ttattggaga cttgacagca aatgtctaac     2100

attatttcag aatgaatctg gatcaaagta ttataaggaa attccacttt cagaaattct     2160

ccgcatatct tcaccacgag atttcacaaa catttcacaa ggcagcaatc cacactgttt     2220

tgaaatcatt actgatacta tggtatactt cgttggtgag aacaatgggg acagctctca     2280

taatcctgtt cttgctgcca ctggagttgg acttgatgta gcacagagct gggaaaaagc     2340

aattcgccaa gccctcatgc ctgttactcc tcaagcaagt gtttgcactt ctccagggca     2400

agggaaagat cacaaagatt tgtctacaag tatctctgta tctaattgtc agattcagga     2460

gaatgtggat atcagtactg tttaccagat ctttgcagat gaggtgcttg gttcaggcca     2520

gtttggcatc gtttatggag gaaaacatag aaagactggg agggatgtgg ctattaaagt     2580

aattgataag atgagattcc ccacaaaaca agaaagtcaa ctccgtaatg aagtggctat     2640

tttacagaat ttgcaccatc ctgggattgt aaacctggaa tgtatgtttg aaaccccaga     2700

acgagtcttt gtagtaatgg aaaagctgca tggagatatg ttggaaatga ttctatccag     2760

tgagaaaagt cggcttccag aacgaattac taaattcatg gtcacacaga tacttgttgc     2820

tttgaggaat ctgcatttta agaatattgt gcactgtgat ttaaagccag aaaatgtgct     2880

gcttgcatca gcagagccat ttcctcaggt gaagctgtgt gactttggat ttgcacgcat     2940

cattggtgaa aagtcattca ggagatctgt ggtaggaact ccagcatact tagcccctga     3000

agttctccgg agcaaaggtt acaaccgttc cctagatatg tggtcagtgg gagttatcat     3060

ctatgtgagc ctcagtggca catttccttt taatgaggat gaagatataa atgaccaaat     3120

ccaaaatgct gcatttatgt acccaccaaa tccatggaga gaaatttctg gtgaagcaat     3180

tgatctgata aacaatctgc ttcaagtgaa gatgagaaaa cgttacagtg ttgacaaatc     3240

tcttagtcat ccctggctac aggactatca gacttggctt gaccttagag aatttgaaac     3300

tcgcattgga gaacgttaca ttacacatga aagtgatgat gctcgctggg aaatacatgc     3360

atacacacat aaccttgtat acccaaagca cttcattatg gctcctaatc cagatgatat     3420

ggaagaagat ccttaatcac tgagctaacc taaataagga aggatttcat tttatggact     3480

gatattttgc tgtgtaactt gttctttgta gattgtcatc tgcagtgctg caaagatatg     3540

aagaaatatg ataacgaata agtgacacca gtactgtagt tcataatgag taggtacagg     3600

cgggaaactg aataataaga agtcataatg gaatcaaggt gaagcttttt ataaactttt     3660

ttagcctaag caataactgg ttttgtattt tttcttaatc cttcacttta atacaatagg     3720

ctcacttaat ttgtcttccc atttctcttt atatatatat atataaatat aaatatatgt     3780

ttgtttgttt ttttaatgaa aaacaagtca agctagcatc cagttactat atagcttggc     3840

taaattatac aagacttaca agattgatta ctcgacaggc ttgtatttaa gaggtaactg     3900

tgaggttacc attatgtgat gttactataa ggacttttaa cattggttta acaaaccata     3960

gaggcattga agggtttttc ttagatgcct agaaaaagcg cactgggctg ttttaccttt     4020

cttttttagg tcaatcaaga ctccaaaata gtgattccta acctttttgg agttgctctg     4080

ctactctgaa tatgttctat acagcataag gattgtcacc ttctgtgtgt tgcaacagct     4140

tctaagataa ttagggacaa atgatgttac aaaaggaaga gtactgctgg tctaagtgct     4200

gagttgtatg tctttgcata gctccactct gctgctaaat atgcatgttc tgactgacac     4260

catcttgatg ccagtactgg attccagcat tcagcaggtg cagatctcgg ctttacacaa     4320

tttatcttta cctagggttc agtcagtaat ttctgctttt tagcagggcc agtgcagggt     4380

cagttaatgc tacagttact gtatagcaaa cagtatcctt ttttctcctt cccctagcct     4440

attgggcttt gcagatatct ggagtgtttt aaagtcaatt attttaagca gtttgagggg     4500

atgtgtagga gtggagcatg aaacagttta taaggctggg gctgtattat cagcacagca     4560

aattaaagaa tgaaagaagt acttcttttt acatttcagc tccagcagcc agctatttaa     4620

aaaatatttt taaatatctt ccccaaagtt taagatgtgg gaccatctac ttgtaagaaa     4680

cagtggctta tttcttcatt tctcagtaat cattgtaaac cttttttttt ttcttctcca     4740

ctctaacaaa agtaaaagaa caaaactttt gctgaggtct tggactccac tacttgttag     4800

ttatgttggc ctggacagat ggcaggtctg tcggcagttc ctcagtctgt aaaatgaaga     4860

ttatcattct tgcctctccc tttgtcacag tgttgtcgtg aagatcagat atgtatgaat     4920

gcagtcaaat aaactaaaaa ctaggaaagt gttaactatc gttgcccacc gaatttgagg     4980

tagcaaaaaa aaaaaagaat gttctggtac atgaacagac tgagaaggcc tttcgacatc     5040

cctgaagcta gtctcctgtc tagactaaaa atatccttga aagaatagta gcaaacagta     5100

tgcagtactc ctgtgttcta agttctttta tgttttagtt taccctcaca gcagccatag     5160

tgttaagtca ttatgagctt catcttaaag ataagaaaac tgaggcaagg ggagattaac     5220

ttactgccaa atttcaaaca gttagtagta tttgagacca gtagtatggc tctaatctta     5280

cccttagccc tcccaaccat tatgctgtac tatctaccca taaatacctc caggaaacat     5340

tcccctcttg gtaatttgtc cttctataga agcttcaaag attaaatcaa attaattttc     5400

aaaaaaaatt tttttttaga aatgttattt tccctgtgat agaggatgac ttcccagttt     5460

caccaaagtc tgtttatatc aacacacaca aaatggaata attctgagtc actaggcaat     5520

caatctactg tggttttact atgtaaggtg aaaattaact ggaacgatgt ttgtttgcta     5580

tacttacata gtcaaacttt acaagccatg aaattaattg cactctttgt atttgttgtt     5640

aaatgcctaa gaagttttct aaaaattttg taaaggcact gtcagagaat ctggagttga     5700

atgattattc cagatactgt ataacctgca taactttttg tctttaagtc gtgtttgtaa     5760

aagaagtaat tgctagaaac atttgataat gtacaaagta gtctataatg actgttcagt     5820

acatttttaa tatttttttg gttatatcca actttttgta aatatactgg aagcttgata     5880

ataaaatgta tttcctatca ccatactttt ccatgtgaaa acctgagcct atttctagta     5940

taagtatcca aagaaaagtt tgacctggtt gtgttatttt accagacctt ggtaaaagaa     6000

ctattttgga aacagtattt gtaaatggaa ctaatgctat atttaaaaac actgattttt     6060

ttttaacctg ccaaaaataa aaaaaagctc attttataat tttctactaa a              6111


<210> 2062
<211> 5486
<212> DNA
<213> Homo sapiens

<400> 2062
ccagttttgg gctggttggc gcggaatcgg gagattcggg accatggcac ctgtgcacgg       60

cgacgactgt gagatagggg cgagtgctct gtcagattca gggagttttg tatcttctcg      120

agcccggcga gaaaaaaaat caaagaaggg gcgccaagaa gccctagaaa gactgaaaaa      180

ggctaaagct ggtgagaagt ataaatatga agtcgaggac ttcacaggtg tttatgaaga      240

agttgatgaa gaacagtatt cgaagctggt tcaggcacgc caggatgatg actggattgt      300

ggatgatgat ggtattggct atgtggaaga tggccgagag atttttgatg atgaccttga      360

agatgatgcc cttgatgctg atgagaaagg aaaagatggt aaagcacgca ataaagacaa      420

gaggaatgta aagaagctcg cagtgacaaa accgaacaac attaagtcaa tgttcattgc      480

ttgtgctgga aagaaaactg cagataaagc tgtagacttg tccaaggatg gtctgctagg      540

tgacattcta caggatctta acactgagac acctcaaata actccaccac ctgtaatgat      600

actgaagaag aaaagatcca ttggagcttc accgaatcct ttctctgtgc acaccgccac      660

ggcagttcct tcaggaaaaa ttgcttcccc tgtctccaga aaggagcctc cattaactcc      720

tgttcctctt aaacgtgctg aatttgctgg cgatgatgta caggtcgaga gtacagaaga      780

agagcaggag tcaggggcaa tggagtttga agatggtgac tttgatgagc ccatggaagt      840

tgaagaggtg gacctggagc ctatggctgc caaggcttgg gacaaagaga gtgagccagc      900

agaggaagtg aaacaagagg cggattctgg gaaagggacc gtgtcctact taggaagttt      960

tctcccggat gtctcttgtt gggacattga tcaagaaggt gatagcagtt tctcagtgca     1020

agaagttcaa gtggattcca gtcacctccc attggtaaaa ggggcagatg aggaacaagt     1080

attccacttt tattggttgg atgcttatga ggatcagtac aaccaaccag gtgtggtatt     1140

tctgtttggg aaagtttgga ttgaatcagc cgagacccat gtgagctgtt gtgtcatggt     1200

gaaaaatatc gagcgaacgc tttacttcct tccccgtgaa atgaaaattg atctaaatac     1260

ggggaaagaa acaggaactc caatttcaat gaaggatgtt tatgaggaat ttgatgagaa     1320

aatagcaaca aaatataaaa ttatgaagtt caagtctaag ccagtggaaa agaactatgc     1380

ttttgagata cctgatgttc cagaaaaatc tgagtacttg gaagttaaat actcggctga     1440

aatgccacag cttcctcaag atttgaaagg agaaactttt tctcatgtat ttgggaccaa     1500

cacatctagc ctggaactgt tcttgatgaa cagaaagatc aaaggacctt gttggcttga     1560

agtaaaaagt ccacagctct tgaatcagcc agtcagttgg tgtaaagttg aggcaatggc     1620

tttgaaacca gacctggtga atgtaattaa ggatgtcagt ccaccaccgc ttgtcgtgat     1680

ggctttcagc atgaagacaa tgcagaatgc aaagaaccat caaaatgaga ttattgctat     1740

ggcagctttg gtccatcaca gttttgcatt ggataaagca gccccaaagc ctccctttca     1800

gtcacacttc tgtgttgtgt ctaaaccaaa ggactgtatt tttccatatg ctttcaaaga     1860

agtcattgag aaaaagaatg tgaaggttga ggttgctgca acagaaagaa cactgctagg     1920

ttttttcctt gcaaaagttc acaaaattga tcctgatatc attgtgggtc ataatattta     1980

tgggtttgaa ctggaagtac tactgcagag aattaatgtg tgcaaagctc ctcactggtc     2040

caagataggt cgactgaagc gatccaacat gccaaagctt gggggccgga gtggatttgg     2100

tgaaagaaat gctacctgtg gtcgaatgat ctgtgatgtg gaaatttcag caaaggaatt     2160

gattcgttgt aaaagctacc atctgtctga acttgttcag cagattctaa aaactgaaag     2220

ggttgtaatc ccaatggaaa atatacaaaa tatgtacagt gaatcttctc aactgttata     2280

cctgttggaa cacacctgga aagatgccaa gttcattttg cagatcatgt gtgagctaaa     2340

tgttcttcca ttagcattgc agatcactaa catcgctggg aacattatgt ccaggacgct     2400

gatgggtgga cgatccgagc gtaacgagtt cttgttgctt catgcatttt acgaaaacaa     2460

ctatattgtg cctgacaagc agattttcag aaagcctcag caaaaactgg gagatgaaga     2520

tgaagaaatt gatggagata ccaataaata caagaaagga cgtaagaaag cagcttatgc     2580

tggaggcttg gttttggacc ccaaagttgg tttttatgat aagttcattt tgcttctgga     2640

cttcaacagt ctatatcctt ccatcattca ggaatttaac atttgtttta caacagtaca     2700

aagagttgct tcagaggcac agaaagttac agaggatgga gaacaagaac agatccctga     2760

gttgccagat ccaagcttag aaatgggcat tttgcccaga gagatccgga aactggtaga     2820

acggagaaaa caagtcaaac agctaatgaa acagcaagac ttaaatccag accttattct     2880

tcagtatgac attcgacaga aggctttgaa gctcacagcg aacagtatgt atggttgcct     2940

gggattttcc tatagcagat tttacgccaa accactggct gccttggtga catacaaagg     3000

aagggagatt ttgatgcata cgaaagagat ggtacaaaag atgaatcttg aagttattta     3060

tggagataca gattcaatta tgataaacac caatagcacc aatctggaag aagtatttaa     3120

gttgggaaac aaggtaaaaa gtgaagtgaa taagttgtac aaactgcttg aaatagacat     3180

tgatggggtt ttcaagtctc tgctactgct gaaaaaaaag aagtacgctg ctctggttgt     3240

tgagccaacg tcggatggga attatgtcac caaacaggag ctcaaaggat tagatatagt     3300

tagaagagat tggtgtgatc ttgctaaaga cactggaaac tttgtgattg gccagattct     3360

ttctgatcaa agccgggaca ctatagtgga aaacattcag aagaggctga tagaaattgg     3420

agaaaatgtg ctaaatggca gtgtcccagt gagccagttt gaaattaaca aggcattgac     3480

aaaggatccc caggattacc ctgataaaaa aagcctacct catgtacatg ttgccctctg     3540

gataaattct caaggaggca gaaaggtgaa agctggagat actgtgtcat atgtcatctg     3600

tcaggatgga tcaaacctca ctgcaagtca gagggcctat gcgcctgagc agctgcagaa     3660

acaggataat ctaaccattg acacccagta ctacctggcc cagcagatcc acccagtcgt     3720

ggctcggatc tgtgaaccaa tagacggaat tgatgctgtc ctcattgcaa cgtggttggg     3780

acttgacccc acccaattta gagttcatca ttatcataaa gatgaagaga atgatgctct     3840

acttggtggc ccagcacagc tcactgatga agagaaatac agggactgtg aaagattcaa     3900

atgtccatgc cctacatgtg gaactgagaa tatttatgat aatgtctttg atggttcggg     3960

aacagatatg gagcccagct tgtatcgttg cagtaacatc gattgtaagg cttcacctct     4020

gacctttaca gtacaactga gcaacaaatt gatcatggac attagacgtt tcattaaaaa     4080

gtactatgat ggctggttga tatgtgaaga gccaacctgt cgcaatcgaa ctcgtcacct     4140

tccccttcaa ttctcccgaa ctgggcctct ttgcccagcc tgcatgaaag ctacacttca     4200

accagagtat tctgacaagt ccctgtacac ccagctgtgc ttttaccggt acatttttga     4260

tgcggagtgt gcactggaga aacttactac cgatcatgag aaagataaat tgaagaagca     4320

attttttacc cccaaagttc tgcaggacta cagaaaactc aagaacacag cagagcaatt     4380

cttgtcccga agtggctact ccgaagtgaa tctgagcaaa ctcttcgctg gttgtgccgt     4440

gaaatcctaa gggaatccca ggagtaacca aggagggggt agttgaaaaa tcccagcttc     4500

ctctgtgcct ccactctggc cctaaatgct cctccagcat ctgtttctcc cttgggactg     4560

tgtctcatgt ttgtgtgaat gtagaccagg aaagggggct gcaaaaatgt tgagtctaat     4620

gttcgtaagc atcatagaaa ttcctgtctt catattaaga tgtactgctt taaaacacaa     4680

ctccagagcc cctccccaag ctcccctccc caagctcctg aagacccggt ttctgaggga     4740

gggaaattgc tacttggatt gagagtagct ggaatgtaag tgaccccagg ctttgcctca     4800

gggcctttag cctatgtccc ccccacataa agagagcttc tcagagcctg actgaagagc     4860

tgacgttttg ctttttcata tgccaattaa acccggtcta aatccaaatg cttctccagc     4920

catccaggag tggctgtcct tttcagtctt gtcttttata taggtagctg agggggaaga     4980

tttagaagcc ttgcactcac taaatagatt aaacagagca ggcttgtttg ttgaattgct     5040

ccaaagtcca acagacacac actgagcagg tgttttacac tcacattccc tttttgcccc     5100

ttaaatagaa agtgcaggta aaggtttata caacaagaaa gcacattgaa aataatttga     5160

tactctaaca atccattaac atgtgtaggg gttacggtga ggatcactgt gttgtattca     5220

gaaaaacggg gagagggatg cttaattggc cctggcgctt gctatttttt tctcatttct     5280

tcacaatagg accgtctttg gcagcagcaa aatgtatttc agtatggcag tctttcctct     5340

cttacattat tggtaagatt atactaacaa aatgtttccc cttgtacaat tatgctgtgt     5400

ttttaaaaaa cattgacctg tgtgttttta taaaagaaaa agtatgttgt gccttcttct     5460

taagaataaa gttttctaaa gggaaa                                          5486


<210> 2063
<211> 497
<212> DNA
<213> Homo sapiens

<400> 2063
gcctatattt ctttggtttt caattacgag tggctcttct cagcaagtgt tccatgatgg       60

ttgagccctt cttgggaacc tggaagctgg tctccagtga aaactttgag gattacatga      120

aagaactggg agtgaatttc gcagcccgga acatggcagg gttagtgaaa ccgacagtaa      180

ctattagtgt tgatgggaaa atgatgacca taagaacaga aagttctttc caggacacta      240

agatctcctt caagctgggg gaagaatttg atgaaactac agcagacaac cggaaagtaa      300

agagcaccat aacattagag aatggctcaa tgattcacgt ccaaaaatgg cttggcaaag      360

agacaacaat caaaagaaaa attgtggatg aaaaaatggt agtggaatgt aaaatgaata      420

atattgtcag caccagaatc tacgaaaagg tgtgaagaaa ggtccacagc aatgaaaact      480

tgttcactga caaggaa                                                     497


<210> 2064
<211> 3272
<212> DNA
<213> Homo sapiens

<400> 2064
gcgggagtcg ccggcggagg cgaggaggag ctctgcgcgg cgcggcgggc gatccgagcc       60

gggacgggct gcaggcgggg gtgctgcaga ggacacgagg cggcgggctg gagacatgga      120

ccgcggcgag caaggtctgc tgagaacaga cccagtccct gaggaaggag aagatgttgc      180

tgccacgatc agtgccacag agaccctctc ggaagaggag caggaagagc taagaagaga      240

acttgcaaag gtagaagaag aaatccagac tctgtctcaa gtgttagcag caaaagagaa      300

gcatctagca gagatcaagc ggaaacttgg aatcaattct ctacaggaac taaaacagaa      360

cattgccaaa gggtggcaag acgtgacagc aacatctgct tacaagaaga catctgaaac      420

cttatcccag gctggacaga aggcctcagc tgctttttcg tctgttggct cagtcatcac      480

caaaaagctg gaagatgtaa aaaactcccc aacttttaaa tcatttgaag aaaaggtcga      540

aaacttaaag tctaaagtag ggggaaccaa gcctgctggt ggtgattttg gagaagtctt      600

gaattcggct gcaaatgcta gtgccaccac cacggagcct cttccagaaa agacacagga      660

gagcctgtga gattcctacc tttgttctgc tacccactgc cagatgctgc aagcgaggtc      720

caagcacatc ttgtcaacat gcattgccat gaatttctac cagatgtgct tttatttagc      780

tttacatatt cctttgacca aatagtttgt gggttaaaca aaatgaaaat atcttcacct      840

ctattcttgg gaaacaccct ttagtgtaca tttatgttcc tttatttagg aaacaccatt      900

ataaaaacac ttatagtaaa tggggacatt cactataatg atctaagaag ctacagattg      960

tcatagttgt tttcctgctt tacaaaattg ctccagatct ggaatgccag tttgaccttt     1020

gtcttctata atatttcctt tttttcccct ctttgaatct ctgtatattt gattcttaac     1080

taaaattgtt ctcttaaata ttctgaatcc tggtaattaa aagtttgggt gtattttctt     1140

tacctccaag gaaagaacta ctagctacaa aaaatatttt ggaataagca ttgttttggt     1200

ataaggtaca tattttggtt gaagacacca gactgaagta aacagctgtg catccaattt     1260

attatagttt tgtaagtaac aatatgtaat caaacttcta ggtgacttga gagtggaacc     1320

tcctatatca ttatttagca ccgtttgtga cagtaaccat ttcagtgtat tgtttattat     1380

accacttata tcaacttatt tttcaccagg ttaaaatttt aatttctaca aaataacatt     1440

ctgaatcaag cacactgtat gttcagtagg ttgaactatg aacactgtca tcaatgttca     1500

gttcaaaagc ctgaaagttt agatctagaa gctggtaaaa atgacaatat caatcacatt     1560

aggggaacca ttgttgtctt cacttaatcc atttagcact atttaaaata agcacaccaa     1620

gttatatgac taatataact tgaaaatttt ttatactgag gggttggtga taactcttga     1680

ggatgtaatg cattaataaa aatcaactca tcattttcta cttgttttca atgtgttgga     1740

aactgtaaaa tgatactgta gaacctgtct cctactttga aaactgaatg tcagggctga     1800

gtgaatcaaa gtgtctagac atatttgcat agaggccaag gtattctatt ctaataactg     1860

cttactcaac actaccacct tttccttata ctgtatatga ttatggccta caatgttgta     1920

tttgttattt attaaattgt gattgtttta ttattgttta tgccaaatgt taactgccaa     1980

gcttggagtg acctaaagca ttttttaaaa gcatggctag atttacttca gtataaatta     2040

tcttatgaaa accaaatttt aaaagccaca ggtgttgatt gttataaaat aacatgctgc     2100

cattcttgat tgctagagtt tttgttagta ctttggatgc aattaaaact atgtgctatc     2160

acatgtgaaa agcttaataa attccatcta tcagtagtat aggtctcaat atttattatg     2220

agaccagtgg tctggaaaca gcttgttgta ccgaatcaac tggagtctat gcttaaaaaa     2280

aaaaaatttt tttttaacca tccttaaatt attgcttaat ggtatcatat taacatattc     2340

taaataaggg ctttaaggca caggctgttg aagcattttc tcagaggagt ggatctgtag     2400

aagtctgtct ttctatagaa atattgtgct tactcaagtg ttaaattatt ttttctatga     2460

actagtctac ttcttaaaat tcaaacatat tcttttgatc acattgtttc ttgagcatcc     2520

tgccctgcta ctaacttttc aacaaggcaa aatggagtaa agtggcaatt tctttagatg     2580

agtgaaatac cctcaagtct cttttctgcc caaaaaggga aaagtgatag aaatgggggt     2640

ggcaagtggg gtgagtggat gaaggtgggt attgggggtg gctgtgaaag aaaataatgg     2700

agaatcactt ttctagacat ctacctatac ttaatctaag aaacaaagta atctactgta     2760

aagtactctg ccccttgaaa gaagtattaa aaagagtgag gatggattta gaaaaaaaca     2820

tgaatttaga aatattcaaa atggtttttg tggcagattc aatattatga attcacagat     2880

atttaaagaa tgagaaacat agtaattagt agaaatgcca gaaacagttc ctggttcctc     2940

ttgtgtttga cactaagaaa atagcaagag tgtgaaatct cagatactta tgaaatctca     3000

cagatgtaag gactcaagtg tagaagaaaa tatccccttc ttacaaaaag aaatgtcaat     3060

ttatggagtt tgtgggaaat agggcaagaa ttcttatgct tatgagagcc aagtagtcag     3120

tggaagagag tagagctcaa aactggatta tcaccttagc aacttagaat agtttgaaat     3180

agaaaaaaag tatttaattt ggatctggat ctgttaagat atgcacagtc tattttttgt     3240

atagtattgg aaaataaaaa tgctataatt tg                                   3272


<210> 2065
<211> 2563
<212> DNA
<213> Homo sapiens

<400> 2065
gcctgaactg tttgtacctc tgggccatat tgcagaaccc tgcccttctt tgttgactga       60

ggaaagctcg ctccctgccc aggtttttca ttgttgatcg aaattaacac caggtggtga      120

atagagcccc tcctaaggtt gctcaggata aatcatttat taaataggtc tgcttatcag      180

gaggggcgtg aaggctccca aaaggaaatg ctggcacctg ggcccagaag ccagggcctc      240

taactcctgg ggttgatttc ttcagtgaag ttgcacccta caaagggaat atggccaaag      300

cggcactcaa ctgaaggctg atatcaggcg attagacagc catgcattct gcgtttgtct      360

ggaatggatt gtagagagat ggacttatat gaggactacc agtccccgtt tgattttgat      420

gcaggagtga acaaaagcta tctctacttg tctcctagtg gaaattcatc tccacccgga      480

tcacctactc ttcagaaatt tggtctgctg agaacagacc cagtccctga ggaaggagaa      540

gatgttgctg ccacgatcag tgccacagag accctctcgg aagaggagca ggaagagcta      600

agaagagaac ttgcaaaggt agaagaagaa atccagactc tgtctcaagt gttagcagca      660

aaagagaagc atctagcaga gatcaagcgg aaacttggaa tcaattctct acaggaacta      720

aaacagaaca ttgccaaagg gtggcaagac gtgacagcaa catctgctta caagaagaca      780

tctgaaacct tatcccaggc tggacagaag gcctcagctg ctttttcgtc tgttggctca      840

gtcatcacca aaaagctgga agatgtaaaa aactccccaa cttttaaatc atttgaagaa      900

aaggtcgaaa acttaaagtc taaagtaggg ggaaccaagc ctgctggtgg tgattttgga      960

gaagtcttga attcggctgc aaatgctagt gccaccacca cggagcctct tccagaaaag     1020

acacaggaga gcctgtgaga ttcctacctt tgttctgcta cccactgcca gatgctgcaa     1080

gcgaggtcca agcacatctt gtcaacatgc attgccatga atttctacca gatgtgcttt     1140

tatttagctt tacatattcc tttgaccaaa tagtttgtgg gttaaacaaa atgaaaatat     1200

cttcacctct attcttggga aacacccttt agtgtacatt tatgttcctt tatttaggaa     1260

acaccattat aaaaacactt atagtaaatg gggacattca ctataatgat ctaagaagct     1320

acagattgtc atagttgttt tcctgcttta caaaattgct ccagatctgg aatgccagtt     1380

tgacctttgt cttctataat atttcctttt tttcccctct ttgaatctct gtatatttga     1440

ttcttaacta aaattgttct cttaaatatt ctgaatcctg gtaattaaaa gtttgggtgt     1500

attttcttta cctccaagga aagaactact agctacaaaa aatattttgg aataagcatt     1560

gttttggtat aaggtacata ttttggttga agacaccaga ctgaagtaaa cagctgtgca     1620

tccaatttat tatagttttg taagtaacaa tatgtaatca aacttctagg tgacttgaga     1680

gtggaacctc ctatatcatt atttagcacc gtttgtgaca gtaaccattt cagtgtattg     1740

tttattatac cacttatatc aacttatttt tcaccaggtt aaaattttaa tttctacaaa     1800

ataacattct gaatcaagca cactgtatgt tcagtaggtt gaactatgaa cactgtcatc     1860

aatgttcagt tcaaaagcct gaaagtttag atctagaagc tggtaaaaat gacaatatca     1920

atcacattag gggaaccatt gttgtcttca cttaatccat ttagcactat ttaaaataag     1980

cacaccaagt tatatgacta atataacttg aaaatttttt atactgaggg gttggtgata     2040

actcttgagg atgtaatgca ttaataaaaa tcaactcatc attttctact tgttttcaat     2100

gtgttggaaa ctgtaaaatg atactgtaga acctgtctcc tactttgaaa actgaatgtc     2160

agggctgagt gaatcaaagt gtctagacat atttgcatag aggccaaggt attctattct     2220

aataactgct tactcaacac taccaccttt tccttatact gtatatgatt atggcctaca     2280

atgttgtatt tgttatttat taaattgtga ttgttttatt attgtttatg ccaaatgtta     2340

actgccaagc ttggagtgac ctaaagcatt ttttaaaagc atggctagat ttacttcagt     2400

ataaattatc ttatgaaaac caaattttaa aagccacagg tgttgattgt tataaaataa     2460

catgctgcca ttcttgattg ctagagtttt tgttagtact ttggatgcaa ttaaaactat     2520

gtgctatcac atgtgaaaag cttaataaat tccatctatc agt                       2563


<210> 2066
<211> 342
<212> DNA
<213> Homo sapiens

<400> 2066
ccccgcgctg cacgctctcg aggccctgcc gtgtcccgcc ctcgggctcc aaggcctgaa       60

ctaacaactg aggcgggaga accagcacga agatgtgtac ctccctacga gcaccggccc      120

ggaatgcagt gtgctgttac aactcccccg ccgtcatact acccatatcc gaaccttaga      180

tgggacacaa gtcacttcaa gaagtctggt ggtccccaga gaaacaacta tgttatccat      240

cctgagtttg tgtctgagac ctatcccgac tatcgttgct ggtagagcct gggcttgctg      300

tgccaagggg gcagagcaat aaataaactc ttcaacccca aa                         342


<210> 2067
<211> 1692
<212> DNA
<213> Homo sapiens

<400> 2067
agaaagaagg ggagaagaag cggggggatg ggtggagggt agaggggaga aaaatacgtg       60

acaaagaaaa cattctctgc ctgggaggag actctctgag ggtgtagagc tagagggagc      120

attcactggc catgccagta gttaccactg atgctgagtc agaaacaggt atcccaaaat      180

ccctttccaa tgagcctccc tcagaaacca tggaggaaat agagcacaca tgcccacagc      240

ctcgactgac cctgactgca cctgccccat ttgctgatga aaccaactgc cagtgtcaag      300

caccccatga aaaactgacc attgctcagg cccgcttagg aacaccagct gacaggcctg      360

tcagagtata cgccgatgga atatttgacc tcttccactc aggtcatgca agagccctta      420

tgcaagcaaa aacactgttt cccaacagct acttgttggt aggagtttgc agtgatgatc      480

tcacccacaa attcaaaggt ttcaccgtga tgaatgaagc cgagagatac gaagctctca      540

gacactgtcg ctacgtagac gaagttatca gagatgctcc ctggacactc acgccagagt      600

ttctggaaaa acacaagatt gactttgtgg ctcatgatga cattccgtat tcctctgctg      660

gctctgatga tgtttacaag cacataaagg aagcagggat gttcgttcca acgcagagaa      720

cagaaggcat ctcaacatcg gacatcatta ccagaattgt tcgtgactat gatgtttatg      780

cccgacgtaa cctccagaga gggtatacag ccaaggaact gaatgtcagc tttataaatg      840

agaagaggta ccgtttccag aaccaagtgg acaaaatgaa ggaaaaagtc aagaatgtgg      900

aggaaagatc aaaggaattt gtgaacagag tggaagaaaa gagccatgat ctaattcaaa      960

agtgggaaga gaagtcaagg gaattcattg gcaacttcct agaactgttt ggacctgatg     1020

gagcatggaa gcagatgttc caggagagga gcagccggat gctgcaggcc ttatccccga     1080

agcagagccc tgtgagcagc ccaacccgga gccggtcccc ttcccgctcc ccatcgccca     1140

ccttctcatg gcttccactc aaaacctcac ccccttcctc acccaaagca gcctcagcct     1200

ctatcagcag catgagcgag ggggatgagg atgaaaagta gaggctgctg ggaggcaaga     1260

gccgcaccat gcaggatggg gaggagggcg agagtcacag ggttgcctgg gtggtgtttg     1320

aagggtaata gtcacaggag ctgcagctca gcagagagac cctgaactct gctaagggaa     1380

ggtcttggga ccagttctct ctcactctcc gtacagctga agagttgggc gaggtgcaga     1440

gacttctagc tggacaacct acacaaacct tagcgtctag agtcactcta accttgctaa     1500

ggaaggatgc agagttccct agagagactt gcactgatgg ggtgacttct gctttggtcc     1560

ttccaccacc cccaccaagt aaaccacctg tggcagcggc tgttccctca acctgctact     1620

tctgcgtcca taagggtcct gcacgttgcc tcccaccacc ccagctctgc cagaataaaa     1680

ttgtttccaa ta                                                         1692


<210> 2068
<211> 5307
<212> DNA
<213> Homo sapiens

<400> 2068
aaagggtaga ggcctctaga gaagataaaa agatcaggag caggcatggt aggccatcag       60

gagtgcatca tggaagagga caatcgcgct ccccaattgt ggcgcaagac cctgactgca      120

cctgccccat ttgctgatga aaccaactgc cagtgtcaag caccccatga aaaactgacc      180

attgctcagg cccgcttagg aacaccagct gacaggcctg tcagagtata cgccgatgga      240

atatttgacc tcttccactc aggtcatgca agagccctta tgcaagcaaa aacactgttt      300

cccaacagct acttgttggt aggagtttgc agtgatgatc tcacccacaa attcaaaggt      360

ttcaccgtga tgaatgaagc cgagagatac gaagctctca gacactgtcg ctacgtagac      420

gaagttatca gagatgctcc ctggacactc acgccagagt ttctggaaaa acacaagatt      480

gactttgtgg ctcatgatga cattccgtat tcctctgctg gctctgatga tgtttacaag      540

cacataaagg aagcagggat gttcgttcca acgcagagaa cagaaggcat ctcaacatcg      600

gacatcatta ccagaattgt tcgtgactat gatgtttatg cccgacgtaa cctccagaga      660

gggtatacag ccaaggaact gaatgtcagc tttataaatg agaagaggta ccgtttccag      720

aaccaagtgg acaaaatgaa ggaaaaagtc aagaatgtgg aggaaagatc aaaggaattt      780

gtgaacagag tggaagaaaa gagccatgat ctaattcaaa agtgggaaga gaagtcaagg      840

gaattcattg gcaacttcct agaactgttt ggacctgatg gagcatggaa gcagatgttc      900

caggagagga gcagccggat gctgcaggcc ttatccccga agcagagccc tgtgagcagc      960

ccaacccgga gccggtcccc ttcccgctcc ccatcgccca ccttctcatg gcttccactc     1020

aaaacctcac ccccttcctc acccaaagca gcctcagcct ctatcagcag catgagcgag     1080

ggggatgagg atgaaaagta gaggctgctg ggaggcaaga gccgcaccat gcaggatggg     1140

gaggagggcg agagtcacag ggttgcctgg gtggtgtttg aagggtaata gtcacaggag     1200

ctgcagctca gcagagagac cctgaactct gctaagggaa ggtcttggga ccagttctct     1260

ctcactctcc gtacagctga agagttgggc gaggtgcaga gacttctagc tggacaacct     1320

acacaaacct tagcgtctag agtcactcta accttgctaa ggaaggatgc agagttccct     1380

agagagactt gcactgatgg ggtgacttct gctttggtcc ttccaccacc cccaccaagt     1440

aaaccacctg tggcagcggc tgttccctca acctgctact tctgcgtcca taagggtcct     1500

gcacgttgcc tcccaccacc ccagctctgc cagaataaaa ttgtttccaa tagaggtggc     1560

aaagtgcttc tgaaatagtc gagaaaaaga cagattccaa cctcctcagt ccagccactg     1620

agacctgatg ttggaacgca tcagctcctt ccagttccat gaatgtggct catagacaaa     1680

gccttgcttt aggctggtta taaaaggtca tctagtgtga accttaactt tttattcaaa     1740

ggacagtttt gtcaagaact ccacgtaagg cctgatgtgc tcctggttgt actttctcat     1800

cactggtttg acttcattgt tttgcagaaa ttaccttaat ccgtgggaac tgcaacaaag     1860

aaaaacttcc taatatataa aaaagaggag ctgctttgct ttgcctccag gtttagcgga     1920

caagaaatgt ctcctgaagc ttctccttaa aggatgctat tatggaatgg cttttcccat     1980

ttctgaccag ttaacagttt catagacctc aagtaacagt ttgaggtatc aaacatagta     2040

taccaatagg gggtgctacc tgcacgtatc tgttctatat atgctccaat atgtcatccc     2100

cgggtgtatc ccatgtgcaa tatgagtata tagtggtggc attttataat agaccccact     2160

cctgcgctcc accataatac tcctctgaaa tccttggtct caagaaacat ctgttctctt     2220

gtgacttggg cactttgtca agcttattcc agattcctgt ggaaacgttt tatcccaacc     2280

aggaaattag tattttgttc tcgtggcctc ctataacatt tttgggtgaa ggagaactca     2340

agacttttta cagagaactg tgggctcagt tatgatctca gcatctgaat ggtctaggta     2400

gtatcaccat tatctctggc cctaggtttg ccaagtagga tgaagactct aagtgttcct     2460

gctgagttgt ccaaaggtcc tgctccttag tcacctgtgc gaaatgagca gggagagtta     2520

aggcatagaa ccaaactctt tgggttattg tatgggtatg ccagtaaatt cagacacaga     2580

gctggggtct gactgaatag aggcccaaac cagcaacttg taggcagagc ccagaatctc     2640

ttgtgataga aatacccctt ttcagaggcc ttgggaacca gccttctagg tgacaagggg     2700

acaaccagtg aaggaaggcg gcatgtcttt ccccttcttg ttggggttga actacctccc     2760

tatccacttg gagatgagtg ctgtctgctg tgaagcaaaa ctatgaggct gagctggctt     2820

ggaacctctt tgttcttggc actttccttc tccaggactc tgggaagcac tcatatggga     2880

cagagggctg gcaggaacat ggcatgtgaa gaagaaaact tctttttgca gtcaagggcc     2940

acccagaata ttgctcttca gagagggaca agggcctcat tcttccattt ggtctctgtc     3000

ttccatcatg cactcaggtc aagccatgca agtctgccta ccatttgagt tagttggcac     3060

ttgtagcagt gaaggatgag gccagccagg caagggaagg tggcgggaac aagggaagag     3120

aaaaggagga aagaagttcc tggagggagg aaaggaggat aaagaaaatc tgctctcata     3180

aaaccatttc aggacctcac tttacaggtg agactctctt gggaaggcct ttgtgcccct     3240

gctccatggc ccagggcaga tagattcact tttacctgaa tcttatactc tggagcaaat     3300

agtgtatcag gctgactata catttgcagg ccttacacgc catactgaca ggtgccactt     3360

acgtgactca tcagataatg tcaccattgc tgccaattat gggaaataac taatgcctat     3420

tccagggatg agcccaaacc acacataaat gggttctaaa tctcaccctc ctaacctgca     3480

gtgagtcccc ccgttccacc ctcttgaggc tgcaaatcta ctgagaagga atgggaagga     3540

ttctacaacc caacttttga tactttttgg ccatctctca gtctctccca gcccctaccc     3600

ccacaccacc tccctgctcc caggcagaga ccgggttgca ctttgttagg gccagcaggt     3660

caactgtaat ggccaagagt gagttaaggc tggaatgaga aatatgcccc aagcttggag     3720

gggtaagcag gaataacaca aagcaaggaa agagattctt tttgccctag tgaggaaagg     3780

aagcttcaga atgagggctg gaggatagca acttaggact gcagaagggg gcagcttatg     3840

aagatgggag aaagtgggac tgaagttgta ggggagcagg agggtagtga ttttccgctt     3900

ttctttcttt ctttctttta ctttctttct ctttctttct ctctctctct ctttcttttt     3960

ctttcttctt tctctttttc tttcctcttt ttctttcttt ctttttcttt ctctttcttc     4020

cttctttctt tcattcttct ttgttctttc ttctttcttt cttttttttt ttttttgaga     4080

tggagttttg ctcttgttgc tcaggctgga gtgcaatggc acaatctcgg ctcactgcag     4140

cctccacctc ccaggttcaa ggggttcttc tgcctcagcc tcccaagtag ctgggattac     4200

aggtgcctgc cacgacaccc agctaatttt tgtatgttta gtagagacgg ggtttcacca     4260

tgttggccag gctggtctca aattcctgac ctcaggtgat tctcccgcct cggcctccca     4320

aagtgctggg attatgagca cgagccacgg cgtccagccg attttccgct ccctttcaag     4380

tgttaactca ccccctgaca ggtgaagagg gaagggttcc ttttacgcac aaccaaggtt     4440

agcaaatgcc catgcaggat atggggtccc tgcctctctg gttgcttcat ttcagcactt     4500

ctatattagc tgcttatggg gaccctaaaa tgaactggtc acccctccac cagctaagaa     4560

acaagggtgg gattgctgtg ccataagtca cactgaacga cttgcttctg gcaagcatgc     4620

tcctgtgtgt caggacctta ccaaggcaaa gaaatgccag gctcaagagg agcaggacgt     4680

gagacattgg cctggcttct aacctggtct gagtggaaga gacacagctt agggatttca     4740

gttttgctct taggctacta gatactgtta tttcaccccc tgagggaggg acaggaagag     4800

cacggattta ttttctctcc gtcttcagta cttattttag catctagtca taccccaggg     4860

agagatgcga gacggtgtca ctggctcagc tgaagcagat gagcccgtct ctagcagaga     4920

tgtgcctgtt tcttaggcat ccgttcagca ctagtcttgg ccatcagatt tttaaaaaag     4980

aaatagctca tgaggcattt gcaacttctc ctctctagac ttctttctag ttttcctctg     5040

ttgtgtcact gcgatgtgtc cagggacaaa gccataagta gagcatacat acttaagact     5100

atgctgtaca tataagacaa gacctgtctg ggttaaagca cgaccttatg cccaagcatt     5160

tactctggtg ctgaataacg cgaactactg gaatcagcct cccccaactc tgcgcgcccc     5220

ctgcccccct gctcctatcc cattcttgct ctcaaatgga ccacaccatt ctcaactcgt     5280

ttataaataa agggatgcag aattgca                                         5307


<210> 2069
<211> 715
<212> DNA
<213> Homo sapiens

<400> 2069
atggctgata aatccaaatt tattgaatac attgacgaag ctttagaaaa atcaaaagaa       60

actgcactct ctcatttatt tttcacctat caggggattc cttaccccat caccatgtgc      120

acctcagaaa ctttccaagc gctggacacc ttcgaagcca gacatgatga catcgtgcta      180

gcatcttatc caaagtgcgg ttcaaactgg attctccaca ttgtcagtga attaatatat      240

gctgtttcta aaaaaaagta taaatatcca gaattcccag ttcttgaatg tggggattca      300

gaaaaatatc agaatctggc tgctggaata aaacagattg ctgagttctt gggattcttt      360

ctaactgggg agcaaattca aactatctca gtccagagca ccttccaagc catgcgtgcg      420

aagtctcagg acacacacgg tgctgtcggc ccattccttt tccgcaaagg tgaagttggt      480

gattggaaaa atttgttcag tgaaattcag aaccaggaaa tggatgaaaa attcaaagag      540

tgcttagcag gcacctccct cggagcaaag ttgaagtatg aatcatattg ccagggttga      600

ttccagtcaa ttcagcaggc ctagatttat tttccttaat aataattaag tgtaaataat      660

taaatgataa ttcaatcaaa taatcaaata ataattaaac aatattgaaa tctaa           715


<210> 2070
<211> 9233
<212> DNA
<213> Homo sapiens

<400> 2070
gaggagaggg cgcgttagtg agcagcgact gtggcattga tgtttgagca tacttctgaa       60

ctggcttttg ttgagactat cagtatagaa gcatgcgctg tcccaaatcc gctgttacta      120

tgagaaatga agagctgctt ttaagtaacg gcacagccaa caagatgaac ggagctttgg      180

atcactcaga ccaaccagac ccagatgcca ttaagatgtt tgtcggacag atcccccggt      240

catggtcgga aaaggagctg aaagaacttt ttgagcctta cggagccgtc taccagatca      300

acgtcctccg ggaccggagt cagaaccctc cgcagagtaa aggttgttgt ttcgtaacat      360

tttatacaag aaaagctgca cttgaggccc agaatgcact gcacaatatt aaaactttac      420

ctgggatgca tcatcccatt cagatgaaac ctgcagatag tgaaaagtcc aacgctgtgg      480

aagacagaaa attgttcata ggaatggtat cgaagaaatg taatgagaac gacatcaggg      540

tgatgttctc tccatttggc cagatagaag aatgccggat cctccgggga cctgatgggc      600

tgagtcgagg ctgtgcgttt gtcacatttt ctacaagggc aatggcacag aatgcaatca      660

aagccatgca tcagtctcag accatggagg gctgctcttc acctatcgtg gtgaagtttg      720

ctgacactca gaaggacaaa gagcaaaggc gcctccagca gcagctcgct cagcagatgc      780

agcagctcaa cactgccacc tgggggaacc tgacagggct gggcggactg accccacagt      840

atctggcgct cctgcagcag gccacctcct ccagcaacct gggtgcgttc agcggcattc      900

aacaaatggc aggcatgaat gctttacagt tgcagaacct ggcgacgctg gctgctgctg      960

cagctgcggc ccagacctca gccaccagca ccaatgcaaa ccctctctct accacgagca     1020

gcgccctggg agccctcacg agtcccgtgg ctgcttcaac ccccaactcc actgctggtg     1080

cagccatgaa ctccttgacc tctctcggga ctctgcaagg actggctgga gccactgttg     1140

gactgaataa tattaatgca ctagcaggta tggcggctct gaatggagga cttggcgcca     1200

caggcttgac gaatggcacg gctggcacca tggacgccct cacccaggcc tactcaggaa     1260

ttcaacagta cgcagccgcc gcgctgccca ctctgtacag ccagagcctg ctgcagcagc     1320

agagcgctgc aggcagccag aaggaaggtc cagagggggc aaacctcttt atttaccacc     1380

ttccacagga atttggagac caggacattc tgcagatgtt catgcctttt ggaaatgtta     1440

tctctgctaa agtcttcatt gacaaacaga ccaatctgag caagtgcttt ggttttgtta     1500

gctacgacaa tccagtctct gcacaagctg ctatccaagc tatgaatggc tttcagatcg     1560

gcatgaaacg cttgaaggtg cagctgaagc gttccaaaaa cgacagcaaa ccttactgat     1620

cctaacccca gaggctccct gctctcattt tagctttctt agggtaagtc ccacgagcca     1680

gcctgtctca acagggaagg cagaggagga ccacattgcc aacttttacc aagagagacg     1740

gttattttta caataaggcc tccatgtccc cacccacttc ccctacccag tttgccataa     1800

ttaaaacttg ggctactttg tttctattga gtaattcctc ctccagttgt gccactgtat     1860

tctcctttgt tttgcgattt gaatctcctt ttaccttttt ttttaatttt tttcattttt     1920

gctttttttt aaagagaagc atatacacaa ataaatggca tcttgagaat ttaaaaggca     1980

aacaaacaaa cgctaatgtg caattctaac tctgaaacca ctggtgcccc gagagcactg     2040

cctggagaat tcacccctcc ttgcccggcg cccgcccccg gagggagggc ccggtgctta     2100

gaggttaact tggtggccta ggagagggag aagccaggag aagcacttac tccaaccaca     2160

cgtctttcca ctacatcggc ttgttttact aagtaggatt ttattttagg gttcaaagaa     2220

acatgacatt tattggtcaa aatattacac tggttgtcta ttttgttatt gttttatttt     2280

agtttttaga aaggattaat gtacaaaaag atttagagat ctgtttctta aagctacagg     2340

gtttaaaaaa taaaaatgag tgaaaatact tgatgtttct tgaaagataa atttaataat     2400

aataaataaa tacataaata cataaataaa aaagaaagcc acaggcctgt aaattttatt     2460

tgtaaaaaag catttctatt tttatacaaa atttttactg cctcagaaat aatggaagtt     2520

atttattgcc tattgttaac ttattgggta cctaaagagc agttctctgt ctagctagaa     2580

ccttctgaag tagtctctag aggaattgtt ctaggaatgg gctttttttc accgttgaac     2640

cctagacctg aagttcatgc tttatcctct cgttgtttgt atctgtctga ttattttgtt     2700

tgtaacttcc attatctagt ttacagttca gtcgtctgac tttccccgta tgtcacattt     2760

gttgaaactg gaccttctcc ccctgtccct caccccaaaa cacccggaat ccatcccgtt     2820

tcgctctctc cagatggatt ctcttggggt ttcattgtgc tgtggataag gagtgtaaga     2880

aatgcaaatt atgtgaatgg ctcggagact ccctaatgac ctaagatttg cattagtttt     2940

tctcctgcac ccttaaaagt gattttgttg ccgctgcata gattctgtgt aactttttac     3000

tcttccttgt tttttcccta gacatcttca tgcccgttag ttcatcgttt gcctagcatg     3060

tccctgtggc gtctcaaaaa aaagtttcat cgtcccgtca ttgtttctga tgtctttctg     3120

acctcacatc atatttggtt ctcctactga cctttgatct agtttgacct ttgaaatttg     3180

catgtgacct catctagcta tgaattctgg gaagtcaatg tgaaaaacat tgctgcattc     3240

atgcaagact gaaatttatt attagacaaa ttcattatag aaaaaacctg tggcaaaaac     3300

gtttctttct tatttttttt cttttcctaa aacagacttg aaagtattat acagggattg     3360

gcattcttcc cggtcactgg taacaatagc aatatgtgtc cagggacaca gaatgttggt     3420

ttctaacaga ctacttccaa aaacagtttg agaaaaaaac tgtctgattt taagtctcta     3480

gaggtctgta atagttttta catttttcag gcagtgtaaa gttttttgat aaggccattt     3540

taggtggctc actttctcat taagatatat atatagaacc actttttgta gattagtata     3600

agaaaaatat ttaccctgtt ttggggcaaa tgctacctat ttgtgtcacc ttttgctgaa     3660

ctcacagtta gacaatccat ggtttaatgc acatgaaatt acctatattt tatactgttt     3720

caatgtacag gagaaaggtt actgtaaact gtgttatgtt ggtgcttctg tgaattaagt     3780

tgtggtttca tcatgagtct taatgttctt tgttgataag acaagtttag aattggttta     3840

cttaatacaa aaaaaaaaaa aagaatttca aaaaaaaaag ttgtttgctt aaaaaaaatt     3900

tcatgtgagg gaaaaaaaaa aaacctattc cagaataagt tttgtgttgg cttgtgaagc     3960

attgatgtca ttttttttaa ttgtggacta tttagatgtg tttgtgttca gcaaaatgtg     4020

atgttttttt cttttaaaga aaaaaagtga aaatatatag tgccaaattc caaaggtact     4080

tccttcctag agcttcagtg tgtttcttgt gagaagtaat ttgataacat gggtatttta     4140

ttatgtgttt tgtataaatc cctaatattt aaaaaaaaaa acaaaacaaa aaaaggttac     4200

aaagtttgtt aacttgctat cctgtggtct tgttgcctga aattgttatt gtttgttatt     4260

tctctctgat gttttttgta agacattgta taagtgccca tgtcccactt ttttaaccac     4320

tccgcacatc agtgctgtga aggcaacctc accatgtatt ttcttcataa tctatggaaa     4380

cctctaaggt gagaaagttt tgaactttta accctttcta cccagagcta tctggaatgt     4440

tgatgacttt ttatactgtc atgatttgag tttgttttgg ggtgtttcca atttggattt     4500

ttttccctgc atctatcctc taagttgttt cggtttgact actttgttct ttggttaaga     4560

tccaaaagaa aacagaaaac aattccacga ggccaatcta aagggaaaaa atcctacact     4620

acttttacta cttttgatta tttctcattt ttgggaaaag aattcctaat gtgctactag     4680

aattccttct tcagttttaa cgagtaattg gataaaccct gagggaaaac ggaggtagat     4740

tcagcaccta acaatcctgt atgcttttga gatcacgttt agtgctatgt cctagtctag     4800

aatattttca tataccttgc agtaaaacga ctttgtggca ggacagtctc ttgaggggtt     4860

ttgtttctgt ttcctaaata ctcctaaata atatttctaa tcagccatta tgctggggca     4920

tctctgatcc cagtaggtac ctctgaatat accaggtgtc tggagttaga agcccatagc     4980

cctttcccag cctttttggt ttttttaatt gaacacattt catctaagta aagctcagtt     5040

ctttatcaca atttactgac caaataccta gcaccagttc ctgctgccac tttttaaagt     5100

gccatatgac tttctacgaa caggtacctt gctgtcttga caaatcctaa tgtcacgcct     5160

acagccccaa cacaagctcc agtcttcctc ttcggcatgc cctggaagct tcttggcctc     5220

agctcccctt ccccgctcag caccctgtta ggatcagtgt gtgtggatgg gatagccctg     5280

ggatggaaag gactagcctc tactgatgca aaaaaacaaa aagcaacaca aacgtttcct     5340

tcttatagca catgcacttc cttacaatga catgatttgt attatcctca catgtgttta     5400

ctactgctgg ggccttcctt catcctctga gggctatttt gtactttctg cagcaatcag     5460

cttaataaca acacttattg cacctgtctc tctctgagaa cacggtgtgt ctcgacacgt     5520

accacgtacg tggaaacaca agagcccacc acttgaattt ctaagaccat ttcattctga     5580

aacttcttat caattaccta aatctcaacg aaaaacaatt tactgaagcc gactcccctc     5640

cccatctccc tctcaacctc aacccacctg catgcatctc ccccagagga aacactgagg     5700

gtaggggaca ggaggctcag gacgcgccct ctgaatcgag tgtttcttct tcacaagtca     5760

ccaagagagg acatgagggg gaaagtcctt tttgcccttc tccaaaaaat aaccttccac     5820

agagacaaac tgtccttcta tccactttta tcttttaata aatatcaaaa ggaaaaagct     5880

gcaagggtgc aaagggcctg tgccagaaga aaacacacac agggaaaccg ctttttttaa     5940

tcaattgtag agaatagtca tttttaatct aaattagaga attgtgatac aatggcagtc     6000

ctcaaaggcg taacgagttc atctttcttt caccataggg gttatagttg gcttgtgcta     6060

ctctggaatc attttactgt ttgtttttat tatcttaagt gctaattaaa aaaaaaataa     6120

aattttaaaa aaacctgtag tttcattacc tttttgaata atgtcataca aaaaatgtat     6180

ttgttttttt gtgctgtgag aattgatgtt tgtagattaa taatcatttt gtttagaatt     6240

acaaaatagt ttttaaatat tgtctgagaa aagccaaagt taatgcaacc tagtggaaac     6300

tgtaagacca tttgagtatt gtttgtttta ttgatgcatt tggattttgt tgtttgatgg     6360

aatttgagcc aaaaaaaaaa tacgcaggct ttcctatttc tacaactgat tgtacttatg     6420

cattttgtac cagtggaact ttttatactg gagattaaaa aaaaaatgga aatttttgtg     6480

gcttgctctg gtgggcccct gacaatgact gatttcaagt ttgatttcgg gttgattgat     6540

tgattgattg atagaaagaa agttgctttt cttttgagaa ttaaaaactt tggcttgatt     6600

tcttttttcc ctttgcttat atctagcatt agaattttgt cttaaaataa cagcggtaag     6660

tttcactttt tattctgtat tgtgcagtta cacaataagg taattagatt tagaagtact     6720

cagtcacttt aagtggataa atgtattagt taaaacttta gggtttgctt ttttgctgtt     6780

tagatcaaag ttttttctga ttcttctgtc ctcattgtga acataaccgt gtagttgaaa     6840

cagtcaaact tatttttgta atgtatgtta ttgtgtgatg cagttttttg cttctgtctc     6900

caatattaaa ccattttcct aatacttgtt tctctctctg cgtgttgtat tgttggtagt     6960

cattatatgt tggtgataca tctgcacacc tcactgtttc acgtatctgt ttttttctct     7020

atgttgtgta aaaagataca gtcgattcca cttaagtgaa tatctgattt ggggaagagg     7080

aaactgcaca gcagccacct ttgatttatg tacaaccgcc cacttgaact cctgcttcca     7140

agatttatac acttttttcc tacagttcac ctcagtaact gcctttgggg ttggatttgc     7200

caaggtgttt tacggtcttt tgaccacaca ggttaatttc cccttctctc ccctccctca     7260

tgagtctatc cacgcagttc ttaacataca ttccaaactg ctgcggggtt tcctctccac     7320

acccacgagg ccaaacccgc atcattacag tccaactctt cttagacact aatcactttc     7380

taaaagaagt gagttctcca gggaagaaaa atcaacttag ccagtgaaaa gggttaaact     7440

taagtctatt atttgttgcc ctcaatcaaa agatatgtat agaaaagtca tttaaattat     7500

ttatttctac aagctaattg aatccaggag cagctttaat tattaacact aacggaagag     7560

aaaagaagta tttccaaggg ctcaaatgga agctgtactc agtccggtgg aggcaggggg     7620

aggtaaagtt tctcacactc aagtcgtctt catagtttac tgtccttttc caaacaaaag     7680

ctaataacgc catacgcatc cacacactcc ctcctggatg aacctaagtc tcgtccccac     7740

tgtcacccca aggccagtta tcaaaaactg ttccttctct gccctcaaag actgaagccg     7800

caggccctgt tctgcctctg ctcaggaatc tgattgctct taaagtgctc ttacaagatt     7860

ccgtcgatgt ttgctccctc tgtcttatct ctccttccag tattttcaga cgcacaagct     7920

ctgactcagg ccacccagca cctggcagcc ttcctctgcg tgccagtgaa atctctccca     7980

gtaggtgctc aggctcttca ccctctcgtt gcagcagccc ctctggcccg agattgtatt     8040

ttctagtctg ctcaagaaca gaggggcctg gcgaggtgga ggaagggagg ctccctcccc     8100

ggggctggcc gcctcagtga tggtgatgcc accagctcca gcctgcacgg atggagctca     8160

cttcctacca tcacttctgc tttcagtctc ctcatagcct tcggcagtct cctctgaaaa     8220

cacactgcct acgttagtgg gaaaggatgg ctaagggtgt gatttctttt tattagggag     8280

gtgggagggg gatgttggga ggcatggggg gtgattaaat tatcatttcc aaggtgcaag     8340

tgtttatttt tcaaatctat aagtacatag ttccaccatt ttggcacaag acaaaatact     8400

catgctaagc aaaggaagag aaagacaaag ccagtttttg ttgcttttct aaagcaacaa     8460

ataattctcc aaagaagggg atgaaaatgc tagttccttt aagcacttac tgactgtaaa     8520

gttggtccct gcttaaattc atacccatag ttttgagtcg gtatgacacc actgcagtgt     8580

gagcaaggtg aatccgtgtg ccatgcatgg accaccttgg gataccgcag caccatcaac     8640

atccgccttg ctgatggaag ccacacacgc tgcccagccc acagcagtcg cacgcagccg     8700

atgggctcgg actcttagct ggcaggctag gacacacagt gaacattaat gtactgtgaa     8760

tcgttcctga taagtgaata aaacattgtg accaaacaat cagcttattc acttatcagg     8820

aatcgactgt tctgctaatt tgctgttgtt gtttttcatc tctgttgtag ttcactattt     8880

ttgctgtgtt ctgttttctc ctctcatgct tgggcaaatc actgggaata ttatcttcat     8940

gtgaccatga aacgtttcta ttgagtgaaa atgatatctt aacaaaatct atgcacttgc     9000

tatcaggaac acaatactgg atgtgtctta tatatattga actatatagt actcgatttc     9060

ttaaataaag cttaagaaag gactctgttg tgtgtaaagt taatgtgatt atttttcaaa     9120

gcagtgtttc taaggggtat ttttgttctt ttaagtcttg agtgatacag gatatttttc     9180

attaaaatta tatcactggc tttatgactt aatattcaat aaattgactt tgg            9233


<210> 2071
<211> 2114
<212> DNA
<213> Homo sapiens

<400> 2071
acagcccggc ccctgccctg caccaggcca ctgccctgtt ggtgaggagg gtcggagggg       60

cgacctccct gccccctgct ccaagctccc cacccccacc tggaacctgc cggcaggaag      120

cctggccctg gagggtggtc acggcccctc cccagatgcc cggcccacga gaggccaatg      180

gggagcagcc aggaggaggg actccggtgt cagccaagcc agccagacca cgacgcagat      240

ggacactgtg ggccggacct ggagggggca gaaagagcct ctgccacacc cggaccccct      300

gggctcctga acagccaccg gcctgcagac tcggatgaca ctaacgccgc cgggccctca      360

gctgccctcc tggaggggct cctgctgggg ggtgggaagc catcgcccca cagcacccgg      420

ccggggccct tcttctacat tggaggcagc aacggggcca caatcatcag ctcctactgc      480

aaaagcaagg gctggcagcg catccatgac agccgccggg acgactacac gctgaagtgg      540

tgtgaggtca agagccgaga cagctacggc agcttccggg aaggagagca gctgctgtac      600

cagcttccca acaacaagct cctcaccacc aagatcgggc tgctcagcac ccttcgggga      660

cgggcacggg ccatgagcaa ggccagcaag gtgccggggg gggtccaggc caggctggaa      720

aaggacgcag cagcgcccgc cctggaggac ctcccgtgga caagcccagg atacctcagg      780

ccacagaggg tcctgagaat ggaagagttt ttcccagaga cctaccgcct ggacctcaaa      840

cacgagagag aggccttttt caccttgttt gatgaaaccc agatatggat ctgcaagccc      900

acagcctcca accagggcaa aggcatcttc ctgctccgga accaggagga agttgccgcc      960

ctgcaggcca agacccggag catggaggac gaccccatcc accacaagac gccgttccgg     1020

gggcctcagg cgcgggtggt gcagaggtac atccagaacc cgctgctggt ggacgggaga     1080

aagtttgacg tgcgctccta cctgctcatt gcctgcacca caccctacat gatcttcttt     1140

ggccacggct atgctcgcct cacccttagc ctttacgacc cccattccag cgacctcggc     1200

ggccacttga ccaaccagtt catgcagaag aagagccctc tgtacatgct gctgaaggag     1260

cacacggtgt ggagcatgga acacctcaac cgctacatca gtgacacgtt ctggaaggcc     1320

cggggcctcg ccaaggactg ggtcttcacc accctcaagg tgcgtccact gtgccctcca     1380

gtctgggagt gagatccctc ggggcggggg tgtgtggtca ggctgggcac caggcacaca     1440

gatgtccgtg gcgtgcgtgg gcggctgcgc tgaagtgtga cctgaccgtg tggaaccaaa     1500

cccttccagc gtctctgctc acttagctgg cagtgcctgt ccccagcagc cagcaaaggc     1560

ccggacggaa agcccagtcg ggggtctgtc ggcacgagtc ccgcgggcag cctcgccgta     1620

gggtcagggg acagctcggc ttcagtgaca gccaccatgt gaagagtctt tgttcctttc     1680

agatcctcca cttggcaggc agggccaaca gcagcccccg ggccaggtgt cctggagcag     1740

cagcagctgc ccgtgcaggc ccggactctc cctagctaag ggccatgtgc ggtggagtgt     1800

cctaattttg cagggttcct ttctgtgggg gtacctgtgg ggtacttcaa acagccctag     1860

cagcaaaggc ccttgagcag cgcggtgtga aactgggata aaaacggggc ttggccgaag     1920

gacttttatc tgtcttggtc accccggcca ggccccggaa gcagcagcca gggatggtcc     1980

ttcctcaccc acaggcgtgt gtcactgtgg ctgggacggc agcgctcaga ggagcctcca     2040

gttactttcc tcacatctcc caaactctct cttaattgcg ataattcaca gaacataaaa     2100

ttcacgatct taaa                                                       2114


<210> 2072
<211> 2259
<212> DNA
<213> Homo sapiens

<400> 2072
aggaccttgt gggctgggca gcggcctccg gccgggaggc accagctctt cgaacaatgt       60

ttaaaagtct cttctgttca tcctaccggg gtgccgtctc ctgccggtct tttcatctca      120

ccagggccct cgcccgggca ccccccggcc aatggaccac agctgcaccc ggttcatcca      180

ccgccgggga ccacccactc ggacccgagc cggcttcaag aggggcaaga ggccaaggat      240

ccagcagagg cctcgggctc gagtctcagg gaccatccct gcgtcacgtc tgcacccagc      300

accggcctca cagcccggcc cctgccctgc accaggccac tgccctgttg gcccggccca      360

cgagaggcca atggggagca gccaggagga gggactccgg tgtcagccaa gccagccaga      420

ccacgacgca gatggacact gtgggccgga cctggagggg gcagaaagag cctctgccac      480

acccggaccc cctgggctcc tgaacagcca ccggcctgca gactcggatg acactaacgc      540

cgccgggccc tcagctgccc tcctggaggg gctcctgctg gggggtggga agccatcgcc      600

ccacagcacc cggccggggc ccttcttcta cattggaggc agcaacgggg ccacaatcat      660

cagctcctac tgcaaaagca agggctggca gcgcatccat gacagccgcc gggacgacta      720

cacgctgaag tggtgtgagg tcaagagccg agacagctac ggcagcttcc gggaaggaga      780

gcagctgctg taccagcttc ccaacaacaa gctcctcacc accaagatcg ggctgctcag      840

cacccttcgg ggacgggcac gggccatgag caaggccagc aaggtgccgg ggggggtcca      900

ggccaggctg gaaaaggacg cagcagcgcc cgccctggag gacctcccgt ggacaagccc      960

aggatacctc aggccacaga gggtcctgag aatggaagag tttttcccag agacctaccg     1020

cctggacctc aaacacgaga gagaggcctt tttcaccttg tttgatgaaa cccagatatg     1080

gatctgcaag cccacagcct ccaaccaggg caaaggcatc ttcctgctcc ggaaccagga     1140

ggaagttgcc gccctgcagg ccaagacccg gagcatggag gacgacccca tccaccacaa     1200

gacgccgttc cgggggcctc aggcgcgggt ggtgcagagg tacatccaga acccgctgct     1260

ggtggacggg agaaagtttg acgtgcgctc ctacctgctc attgcctgca ccacacccta     1320

catgatcttc tttggccacg gctatgctcg cctcaccctt agcctttacg acccccattc     1380

cagcgacctc ggcggccact tgaccaacca gttcatgcag aagaagagcc ctctgtacat     1440

gctgctgaag gagcacacgg tgtggagcat ggaacacctc aaccgctaca tcagtgacac     1500

gttctggaag gcccggggcc tcgccaagga ctgggtcttc accaccctca agaagcggat     1560

gcagcagatc atggcccact gctttctggc cgccaagccc aagctggact gcaagctggg     1620

ttactttgac ctcattggct gtgacttcct gattgatgac aacttcaagg tatggctgct     1680

ggagatgaat tctaacccag ccctgcacac caactgcgag gtcctgaagg aggtcatccc     1740

aggtgtggtc atcgagaccc tggacctggt gctcgagacc ttccggaaga gcctgcgcgg     1800

ccagaagatg ttgcctctgc tgtcccagcg ccgcttcgtg ctcctgcaca acggtgaggc     1860

cgacccgcgg ccgcacctgg ggggctcgtg cagcctccgc cgctggccgc ccctgcccac     1920

ccgccaggcc aagtcctccg ggccacccat gccgcatgcc ccagaccagc cgggcgcccg     1980

caggcctgcg ccacctccct tggtgccgca gcgtccccgg ccacccggcc ccgacctgga     2040

cagcgcccac gatggggagc cccaggcccc gggcacggag cagtcgggca caggcaacag     2100

gcacccggcg caagagcctt ccccggggac agccaaggag gaacgcgagg agcctgagaa     2160

cgcgaggccc taggggcagc cacccgcgcc cagcgccccg cgccccgcgc cccagccgtg     2220

ctgcctgccc tcagggacct ataaagccca ctttgctac                            2259


<210> 2073
<211> 2283
<212> DNA
<213> Homo sapiens

<400> 2073
cccaggacct tgtgggctgg gcaggtcgtg cgtcctttga cagcggcctc cggccgggag       60

gcaccagctc ttcgaacaat gtttaaaagt ctcttctgtt catcctaccg gggtgccgtc      120

tcctgccggt cttttcatct caccagggcc ctcgcccggg caccccccgg ccaatggacc      180

acagctgcac ccggttcatc caccgccggg gaccacccac tcggacccga gccggcttca      240

agaggggcaa gaggccaagg atccagcaga ggcctcgggc tcgagtctca gggaccatcc      300

ctgcgtcacg tctgcaccca gcaccggcct cacagcccgg cccctgccct gcaccaggcc      360

actgccctgt tggcccggcc cacgagaggc caatggggag cagccaggag gagggactcc      420

ggtgtcagcc aagccagcca gaccacgacg cagatggaca ctgtgggccg gacctggagg      480

gggcagaaag agcctctgcc acacccggac cccctgggct cctgaacagc caccggcctg      540

cagactcgga tgacactaac gccgccgggc cctcagctgc cctcctggag gggctcctgc      600

tggggggtgg gaagccatcg ccccacagca cccggccggg gcccttcttc tacattggag      660

gcagcaacgg ggccacaatc atcagctcct actgcaaaag caagggctgg cagcgcatcc      720

atgacagccg ccgggacgac tacacgctga agtggtgtga ggtcaagagc cgagacagct      780

acggcagctt ccgggaagga gagcagctgc tgtaccagct tcccaacaac aagctcctca      840

ccaccaagat cgggctgctc agcacccttc ggggacgggc acgggccatg agcaaggcca      900

gcaaggtgcc ggggggggtc caggccaggc tggaaaagga cgcagcagcg cccgccctgg      960

aggacctccc gtggacaagc ccaggatacc tcaggccaca gagggtcctg agaatggaag     1020

agtttttccc agagacctac cgcctggacc tcaaacacga gagagaggcc tttttcacct     1080

tgtttgatga aacccagata tggatctgca agcccacagc ctccaaccag ggcaaaggca     1140

tcttcctgct ccggaaccag gaggaagttg ccgccctgca ggccaagacc cggagcatgg     1200

aggacgaccc catccaccac aagacgccgt tccgggggcc tcaggcgcgg gtggtgcaga     1260

ggtacatcca gaacccgctg ctggtggacg ggagaaagtt tgacgtgcgc tcctacctgc     1320

tcattgcctg caccacaccc tacatgatct tctttggcca cggctatgct cgcctcaccc     1380

ttagccttta cgacccccat tccagcgacc tcggcggcca cttgaccaac cagttcatgc     1440

agaagaagag ccctctgtac atgctgctga aggagcacac ggtgtggagc atggaacacc     1500

tcaaccgcta catcagtgac acgttctgga aggcccgggg cctcgccaag gactgggtct     1560

tcaccaccct caagaagcgg atgcagcaga tcatggccca ctgctttctg gccgccaagc     1620

ccaagctgga ctgcaagctg ggttactttg acctcattgg ctgtgacttc ctgattgatg     1680

acaacttcaa ggtatggctg ctggagatga attctaaccc agccctgcac accaactgcg     1740

aggtcctgaa ggaggtcatc ccaggtgtgg tcatcgagac cctggacctg gtgctcgaga     1800

ccttccggaa gagcctgcgc ggccagaaga tgttgcctct gctgtcccag cgccgcttcg     1860

tgctcctgca caacggtgag gccgacccgc ggccgcacct ggggggctcg tgcagcctcc     1920

gccgctggcc gcccctgccc acccgccagg ccaagtcctc cgggccaccc atgccgcatg     1980

ccccagacca gccgggcgcc cgcaggcctg cgccacctcc cttggtgccg cagcgtcccc     2040

ggccacccgg ccccgacctg gacagcgccc acgatgggga gccccaggcc ccgggcacgg     2100

agcagtcggg cacaggcaac aggcacccgg cgcaagagcc ttccccgggg acagccaagg     2160

aggaacgcga ggagcctgag aacgcgaggc cctaggggca gccacccgcg cccagcgccc     2220

cgcgccccgc gccccagccg tgctgcctgc cctcagggac ctataaagcc cactttgcta     2280

caa                                                                   2283


<210> 2074
<211> 693
<212> DNA
<213> Homo sapiens

<400> 2074
gcggcggcgg cagcggcagc ggcagcggcg ctgagttttg tctcccgggc cgtctgggcg       60

cgcgcgggtg tcccaggtac cccgccgcct ccctccttcc cgcaggactc gtccctcctg      120

gccctgggcc ccaacggtgc ccgcctgccc ggcggtcggt cagcgcacag ggcacggctt      180

cctctgcttc tcccggacca cttagtctca acccgggtgt gtttgcacta ctagagactc      240

acttttcccc ttcgtctttc tctccctttc tgtctttctg tgtctcctcc aagaatgaaa      300

tatgactgag gactctcaga gaaactttcg ttcagtatat tatgagaaag tggggtttcg      360

tggagttgaa gaaaagaaat cattagaaat tctcctaaaa gatgaccgtc tggatactga      420

gaaactttgt acttttagtc agaggttccc tctcccgtcc atgtaccgtg cattggtatg      480

gaaggtgctt ctaggaatct tgcctccaca ccacgagtcc catgccaagg tgatgatgta      540

tcgtaaggag cagtacttgg atgtccttca tgccctgaaa gtcgttcgct ttgttagtga      600

tgccacacct caggctgaag tctatctccg catgtatcag ctggagtctg ggaagttacc      660

tcgaagtccc tcttttccac tggagccaga tga                                   693


<210> 2075
<211> 1276
<212> DNA
<213> Homo sapiens

<400> 2075
gcggcggcgg cagcggcagc ggcagcggcg ctgagttttg tctcccgggc cgtctgggcg       60

cgcgcgggtg tcccaggtac cccgccgcct ccctccttcc cgcaggactc gtccctcctg      120

gccctgggcc ccaacggtgc ccgcctgccc ggcggtcggt cagcgcacag ggcacggctt      180

cctctgcttc tcccggacca cttagtctca acccgggtgt gtttgcacta ctagagaatg      240

aaatatgact gaggactctc agagaaactt tcgttcagta tattatgaga aagtggggtt      300

tcgtggagtt gaagaaaaga aatcattaga aattctccta aaagatgacc gtctggatac      360

tgagaaactt tgtactttta gtcagaggtt ccctctcccg tccatgtacc gtgcattggt      420

atggaaggtg cttctaggaa tcttgcctcc acaccacgag tcccatgcca aggtgatgat      480

gtatcgtaag gagcagtact tggatgtcct tcatgccctg aaagtcgttc gctttgttag      540

tgatgccaca cctcaggctg aagtctatct ccgcatgtat cagctggagt ctgggaagtt      600

acctcgaagt ccctcttttc cactggagcc agatgatgaa gtgtttcttg ccatagctaa      660

agccatggag gaaatggtgg aagatagtgt cgactgttac tggatcaccc gacgctttgt      720

gaaccaatta aataccaagt accgggattc cttgccccag ttgccaaaag cgtttgaaca      780

atacttgaat ctggaagatg gcagactgct gactcatctg aggatgtgtt ccgcggcgcc      840

caaacttcct tatgatctct ggttcaagag gtgctttgcg ggatgtttgc ctgaatccag      900

tttacagagg gtttgggata aagttgtgag tggatcctgt aagatcctag tttttgtagc      960

tgtcgaaatt ttattaacct ttaaaataaa agttatggca ctgaacagtg cagagaagat     1020

aacaaagttt ctggaaaata ttccccagga cagctcagac gcgatcgtga gcaaggccat     1080

tgacttgtgg cacaaacact gtgggacccc ggtccattca agctgaacgc acccgctggt     1140

tgtggaccgt ctgccaggca ccacagtgag cattgtgttc ttggcatgtg atctgggaaa     1200

ctgattgaat aatacacttt tcttgctttg gtgctcaaag tggttttttt cccccaataa     1260

aattatttaa ttgaaa                                                     1276


<210> 2076
<211> 1045
<212> DNA
<213> Homo sapiens

<400> 2076
gatgtcacgt ccggcggcgg cggcagcggc agcggcagcg gcgctgagtt ttgtctcccg       60

ggccgtctgg gcgcgcgcgg gtgtcccaga atgaaatatg actgaggact ctcagagaaa      120

ctttcgttca gtatattatg agaaagtggg gtttcgtgga gttgaagaaa agaaatcatt      180

agaaattctc ctaaaagatg accgtctggg aatcttgcct ccacaccacg agtcccatgc      240

caaggtgatg atgtatcgta aggagcagta cttggatgtc cttcatgccc tgaaagtcgt      300

tcgctttgtt agtgatgcca cacctcaggc tgaagtctat ctccgcatgt atcagctgga      360

gtctgggaag ttacctcgaa gtccctcttt tccactggag ccagatgatg aagtgtttct      420

tgccatagct aaagccatgg aggaaatggt ggaagatagt gtcgactgtt actggatcac      480

ccgacgcttt gtgaaccaat taaataccaa gtaccgggat tccttgcccc agttgccaaa      540

agcgtttgaa caatacttga atctggaaga tggcagactg ctgactcatc tgaggatgtg      600

ttccgcggcg cccaaacttc cttatgatct ctggttcaag aggtgctttg cgggatgttt      660

gcctgaatcc agtttacaga gggtttggga taaagttgtg agtggatcct gtaagatcct      720

agtttttgta gctgtcgaaa ttttattaac ctttaaaata aaagttatgg cactgaacag      780

tgcagagaag ataacaaagt ttctggaaaa tattccccag gacagctcag acgcgatcgt      840

gagcaaggcc attgacttgt ggcacaaaca ctgtgggacc ccggtccatt caagctgaac      900

gcacccgctg gttgtggacc gtctgccagg caccacagtg agcattgtgt tcttggcatg      960

tgatctggga aactgattga ataatacact tttcttgctt tggtgctcaa agtggttttt     1020

ttcccccaat aaaattattt aattg                                           1045


<210> 2077
<211> 4116
<212> DNA
<213> Homo sapiens

<400> 2077
ggcgcctgcg gcggcgacag cggcagctgc ggcgcgacca ggccgggcac ctccgagcgc       60

aaggacagcg cgaggtccgc gcagcccagc gcagccatgg agccccgcgc ggactcactc      120

tatgatgtcc ctgtcggtgc ggccgcagcg ccgtctgctc agcgcccggg tcaataggag      180

ccagtccttc gcaggcgtcc tcggcagcca cgagcggggg cccagcctct ccttcaggag      240

tttcccggtc ttcagcccgc cggggccccc acggaagccc cccgcgctct cccgagtgtc      300

caggatgttt tccgtggctc acccagccgc caaggtgccg cagcccgagc ggctggacct      360

ggtgtacacg gcgctgaagc ggggcctgac ggcctacttg gaagtgcacc agcaggagca      420

agagaaactc caggggcaga taagggagtc caagaggaat tcccgcttgg gcttcctgta      480

tgatctggac aagcaagtca agtccattga acgcttcctg cgacgactgg agttccatgc      540

cagcaagatc gatgagctgt atgaggcata ctgtgtccag cggcgtctcc gggatggtgc      600

ctacaacatg gtccgtgcct acaccactgg gtccccggga agccgagagg cccgggacag      660

cctggcagag gccactcggg ggcatcgcga gtacacggag agcatgtgtc tgctggagag      720

cgagctggag gcacagctgg gcgagtttca tctccgaatg aaagggctgg ctggcttcgc      780

caggctgtgt gtaggcgatc agtatgagat ctgcatgaaa tatgggcgtc agcgctggaa      840

actacggggc cgaattgagg gtagtggaaa gcaggtgtgg gacagtgaag aaaccatctt      900

tctccctcta ctcacggaat ttctgtctat taaggtgaca gaactgaagg gcctggccaa      960

ccatgtggtt gtgggcagtg tctcctgtga gaccaaggac ctgtttgccg ccctgcccca     1020

ggttgtggct gtggatatca atgaccttgg taccatcaag ctcagcctgg aagtcacatg     1080

gagccccttc gacaaggatg accagccctc agctgcttct tctgtcaaca aggcctccac     1140

agtcaccaag cgcttctcca cctatagcca gagcccaccg gacacaccct cacttcggga     1200

acaggctttc tataacatgc tgcgacggca ggaggagctg gagaatggga cagcatggtc     1260

cctgtcatct gaatcttcag acgactcatc cagcccacag ctctcaggca ctgcccgcca     1320

ctcaccagcc cctaggcccc tggtgcagca gcccgagccc cttcccatcc aagttgcctt     1380

ccgcaggcct gagaccccca gctctgggcc cttggatgag gagggggccg tggccccagt     1440

cctggcaaat gggcatgcac cctacagtcg gactctgagc cacatcagtg aggctagtgt     1500

agatgctgcc ttggctgagg cttcagtgga ggccgttggc ccagaaagcc tagcctgggg     1560

acctagccca cctacacacc cagctcccac ccatggagag caccccagtc ctgttcctcc     1620

tgccctggac cctggccact ctgccacaag ctctaccctc ggtacaacag gctctgtccc     1680

cacatctaca gaccctgccc catctgcaca cctagactca gttcataagt ccacagactc     1740

tggcccttca gaactgccag gccccactca caccactaca ggctctacct atagtgccat     1800

taccactacc cacagtgctc caagccccct cactcacact actacaggct ccacccacaa     1860

gcccataatc tctaccctta ctactacagg ccctaccctc aatatcatag gcccagtcca     1920

gactaccaca agccccaccc acactatgcc aagccctacc cataccacag caagccccac     1980

tcatacttcc acaagcccca cccatacccc cacaagtccc acccacaaaa ccagtatgtc     2040

acctcccacc actacaagtc ctacccccag tggtatgggc ctagtccaga ctgccacaag     2100

tcccacccat cctaccacaa gccccaccca tcccaccaca agccccatcc ttataaatgt     2160

aagcccttcc acttctctag aacttgctac cctctccagc ccctccaaac actcagaccc     2220

caccctccca ggcactgact cccttccctg tagtccccca gtctccaatt cctacactca     2280

ggcagaccct atggccccca gaactcccca cccaagtcct gcccattcca gtaggaaacc     2340

cctcacaagc cctgccccag atccctcaga gtctacggtt cagagtctaa gccccactcc     2400

ctcaccccca acccctgcac cccagcattc agacctttgc ctggccatgg ctgtccagac     2460

cccagtccca acggcagccg gagggtctgg ggacaggagc ctggaggagg cactgggggc     2520

cctaatggct gccctggatg actaccgtgg ccagtttcct gagctgcagg gcctggagca     2580

ggaggtgacc cgcctagaaa gtctgctcat gcagagacaa ggtctgactc gcagccgggc     2640

ctccagtctc agcatcactg tggagcatgc cttggagagc ttcagcttcc tcaatgaaga     2700

cgaagatgaa gacaatgatg ttcctgggga caggcctcca agcagcccgg aggctggggc     2760

tgaggacagc atagactcac ccagtgcccg ccccctcagc acggggtgtc cagctctgga     2820

tgctgccttg gtccggcacc tgtaccactg cagtcgcctc ctgctgaaac tgggcacatt     2880

tgggcccctg cgctgccagg aggcatgggc cctggagcgg ctgctgcggg aagcccgagt     2940

actggaggca gtatgcgagt tcagcaggcg gtgggagatc ccggccagct ctgcccagga     3000

agtggtgcag ttctcggcct ctcggcctgg cttcctgacc ttctgggacc agtgcacaga     3060

gagactcagc tgcttcctct gcccggtgga gcgggtgctt ctcaccttct gcaaccagta     3120

tggtgcccgc ctctccctgc gccagccagg cttggctgag gctgtgtgtg tgaagttcct     3180

ggaggatgcc ctggggcaga agctgcccag aaggccccag ccagggcctg gagagcagct     3240

cacagtcttc cagttctgga gttttgtgga aaccttggac agccccacca tggaggccta     3300

cgtgactgag accgctgagg aggtgctact ggtgcggaat ctgaactcgg atgatcaggc     3360

tgttgtgctg aaggccctga gattggcgcc cgaggggcgt ctgcgaaggg acgggctgcg     3420

ggccctcagc tccctgctcg tccatggcaa caacaaggtc atggctgctg tcagcaccca     3480

gctccggagc ctgtcactgg gccctacctt ccgggagagg gccctcctgt gcttcctgga     3540

ccagctggag gatgaggacg tgcagactcg agtggctggc tgcctggccc taggctgcat     3600

caaggctccc gagggcattg agcccctggt gtacctctgc caaactgaca cagaagctgt     3660

gagggaagct gcccggcaaa gcctacagca gtgtggagaa gagggacagt ctgcccatcg     3720

acggctggag gagtccctgg acgccctgcc ccgcatcttt gggcctggca gcatggccag     3780

cacagcattc taaactattc acccatgggt tcctggtgcc cctttccccc cactttcagg     3840

gctcaccagg cactggcagg gagggtaagg gctggctcca gatacccctc ccccacagat     3900

tcctagcaat gaaaatctaa tatattcttc tgttgcccct ggggttggag agtcagtgcc     3960

tgcagtcaag tgcctcccag cctcggctca gcacatccct tgccacaaat cagtgtctgg     4020

ggcttggcca ccctgccgct gcccagccac atcccttggt tttgtatttt atttacagag     4080

ttttacagaa aataaaaaag caaaatgtct ttccta                               4116


<210> 2078
<211> 154
<212> DNA
<213> Homo sapiens

<400> 2078
gagccatggc ggacgaggag cttgaggcgc tgaggagaca gaggctggcc gagctgcagg       60

ccaaacacgg ggatcctggt gatgcggccc aacaggaagc aaagcacagt tcaacagaag      120

aaaagtaatg gactctgatg aagatgacga ttat                                  154


<210> 2079
<211> 960
<212> DNA
<213> Homo sapiens

<400> 2079
gcggaccgtg ctgggagcgg cgcggctgga gcgcagcgcc gaagggactg gcagggctga       60

agtgtgcggg acagcaagcc cccgaatagc cccggctgcc acctcgcagg acccaaggcc      120

acgcgcgccg ggcccagctg agccgcctca tgaagccgcc cgcggcgcag ggcagccccg      180

cggccgccgc ggccgcagcc ccggccctgg actcggcggc cgcggaggac ctgtcggacg      240

cgctgtgcga gtttgacgcg gtgctggccg acttcgcgtc gcccttccac gagcgccact      300

tccactacga ggagcacctg gagcgcatga agcggcgcag cagcgccagt gtcagcgaca      360

gcagcggctt cagcgactcg gagagtgcag attcacttta taggaacagc ttcagcttca      420

gtgatgaaaa actgaattct ccaacagact ctaccccagc tcttctctct gccactgtca      480

ctcctcagaa agctaaatta ggagacacaa aagagctaga agccttcatt gctgatcttg      540

acaaaacttt agcaagtatg tgaaacaaga agttctgggt cctttcatca taagggagaa      600

gcttcagaaa gttccgagga cctgctaaaa tcagctacta gaatctgctg ccagagggga      660

caaagacgtg cactcaacct tctaccaggc cactctcagg ctcaccttaa aatcagccct      720

tgatcccatt tctgggcaat ttagacagtg aaactgactt tgtttacctg cttgcagcat      780

attagaacag acgatccatg ctaatattgt attttctctt aaaacatagc tttcctgtaa      840

tttaaagtgc ttttatgaaa atatttgtaa ttaattatat atagttggaa atagcagtaa      900

gctttcccat tataatatat ttttgtatac aaataaaatt tgaactgaag tctgcttcct      960


<210> 2080
<211> 1917
<212> DNA
<213> Homo sapiens

<400> 2080
aaagggcgct ccgcgcatgc gcacaggatc cggctcggga ggcggaccct ggctgccatc       60

ttgcagtgcg cgggaaccgc cgccgccgcc gctggccaaa aagcggagcc caggggaagc      120

gtgtcctgct cagaccgcct tccttctcca ttgccacccg tgccgaacag ccaggctgcc      180

caattgcaac tgtagaccaa tgaactaatc catcgcccgc agcccgactc tcagcagcgg      240

ttcgtcccgg tgcccacccc cgcgaagcgg agcgcccggg cacctagcct ccctgccggc      300

cacctagcct ccctgccggc cacgatgccg aacgtgctgc tgccgcccaa ggagagcaac      360

ctcttcaaac gcatcttgaa atgttatgaa cagaagcagt acaaaaatgg cctcaagttt      420

tgcaagatga ttctgtcgaa cccaaaattt gctgaacatg gagagacttt ggctatgaaa      480

ggattaacac tgaactgttt aggaaaaaaa gaagaagctt atgagtttgt tcgtaaagga      540

cttcgtaatg atgtcaagag tcatgtctgt tggcatgtat atggactctt gcagcgttct      600

gataaaaaat atgatgaagc tataaaatgt taccgaaatg ccctcaaatt agataaagat      660

aacctgcaaa ttttgaggga tctctcactg ttgcagatcc aaatgagaga ccttgaaggt      720

taccgagaga caagatacca gcttcttcag ttgcgcccca cacagcgtgc ctcctggatt      780

ggatatgcta ttgcatacca tttgctgaaa gattatgata tggccctaaa actgttggaa      840

gaatttagac aaactcagca agttcctcca aacaaaatag attatgaata tagtgaattg      900

atattatacc agaatcaagt gatgagagag gcagatctgt tgcaggaatc tttggaacat      960

atagaaatgt atgagaaaca aatatgtgat aaacttttgg tggaagaaat taaaggggaa     1020

atactgttga aattgggaag attaaaagaa gccagtgaag tgttcaaaaa cttgattgat     1080

cgaaatgcag aaaattggtg ttattatgaa ggcttggaaa aagctctaca aattagcact     1140

ttagaagaga ggcttcaaat ttatgaagaa attagtaagc agcaccccaa agcaattaca     1200

cccagaagat tacctttgac tcttgtccca ggtgaaagat ttagagaact aatggataag     1260

ttcctgaggg ttaacttcag taaaggctgc ccacccttgt ttactacttt gaaatcttta     1320

tattacaata cagaaaaggt ttctataatc caggaacttg ttactaatta tgaagcctct     1380

cttaaaacgt gtgacttttt tagcccatat gagaatgggg agaaggaacc cccgacaaca     1440

ctactctggg ttcagtattt cctggcacag cactttgata aacttggaca gtattctttg     1500

gctttggatt atattaatgc tgcaattgct agtactccaa ctctaataga attattctat     1560

atgaaagcaa aaatttacaa gcatataggt aatctcaaag aagctgcaaa gtggatggat     1620

gaagcacagt ctttggacac agctgataga ttcatcaatt ccaaatgtgc aaaatacatg     1680

cttcgagcaa atatgataaa agaagcagag gaaatgtgct ccaagttcac aagggaagga     1740

acatctgcca tggaaaatct aaatgaaatg cagtgtatgt ggtttcagac agaatgcatt     1800

tcagcttatc agcgtctggg gagatacggg gatgccttga aaaaatgtca tgaagtagaa     1860

aggcactctc cttccacatg gaccacagga ggaaaagagc cgcaaatgca cccctga        1917


<210> 2081
<211> 4347
<212> DNA
<213> Homo sapiens

<400> 2081
aaagggcgct ccgcgcatgc gcacaggatc cggctcggga ggcggaccct ggctgccatc       60

ttgcagtgcg cgggaaccgc cgccgccgcc gctggccaaa aagcggagcc caggggaagc      120

gtgtcctgct cagaccgcct tccttctcca ttgccacccg tgccgaacag ccaggctgcc      180

caattgcaac tgtagaccaa tgaactaatc catcgcccgc agcccgactc tcagcagcgg      240

ttcgtcccgg tgcccacccc cgcgaagcgg agcgcccggg cacctagcct ccctgccggc      300

cacctagcct ccctgccggc cacgatgccg aacgtgctgc tgccgcccaa ggagagcaac      360

ctcttcaaac gcatcttgaa atgttatgaa cagaagcagt acaaaaatgg cctcaagttt      420

tgcaagatga ttctgtcgaa cccaaaattt gctgaacatg gagagacttt ggctatgaaa      480

ggattaacac tgaactgttt aggaaaaaaa gaagaagctt atgagtttgt tcgtaaagga      540

cttcgtaatg atgtcaagag tcatgtctgt tggcatgtat atggactctt gcagcgttct      600

gataaaaaat atgatgaagc tataaaatgt taccgaaatg ccctcaaatt agataaagat      660

aacctgcaaa ttttgaggga tctctcactg ttgcagatcc aaatgagaga ccttgaaggt      720

taccgagaga caagatacca gcttcttcag ttgcgcccca cacagcgtgc ctcctggatt      780

ggatatgcta ttgcatacca tttgctgaaa gattatgata tggccctaaa actgttggaa      840

gaatttagac aaactcagca agttcctcca aacaaaatag attatgaata tagtgaattg      900

atattatacc agaatcaagt gatgagagag gcagatctgt tgcaggaatc tttggaacat      960

atagaaatgt atgagaaaca aatatgtgat aaacttttgg tggaagaaat taaaggggaa     1020

atactgttga aattgggaag attaaaagaa gccagtgaag tgttcaaaaa cttgattgat     1080

cgaaatgcag aaaattggtg ttattatgaa ggcttggaaa aagctctaca aattagcact     1140

ttagaagaga ggcttcaaat ttatgaagaa attagtaagc agcaccccaa agcaattaca     1200

cccagaagat tacctttgac tcttgtccca ggtgaaagat ttagagaact aatggataag     1260

ttcctgaggg ttaacttcag taaaggctgc ccacccttgt ttactacttt gaaatcttta     1320

tattacaata cagaaaaggt ttctataatc caggaacttg ttactaatta tgaagcctct     1380

cttaaaacgt gtgacttttt tagcccatat gagaatgggg agaaggaacc cccgacaaca     1440

ctactctggg ttcagtattt cctggcacag cactttgata aacttggaca gtattctttg     1500

gctttggatt atattaatgc tgcaattgct agtactccaa ctctaataga attattctat     1560

atgaaagcaa aaatttacaa gcatataggt aatctcaaag aagctgcaaa gtggatggat     1620

gaagcacagt ctttggacac agctgataga ttcatcaatt ccaaatgtgc aaaatacatg     1680

cttcgagcaa atatgataaa agaagcagag gaaatgtgct ccaagttcac aagggaagga     1740

acatctgcca tggaaaatct aaatgaaatg cagtgtatgt ggtttcagac agaatgcatt     1800

tcagcttatc agcgtctggg gagatacggg gatgccttga aaaaatgtca tgaagtagaa     1860

aggcattttt ttgagataac tgatgaccaa ttcgacttcc atacatactg catgagaaag     1920

atgacccttc gtgcctatgt tgaccttttg agattagaag atatactcag aagacatgcc     1980

ttttatttca aggctgctag atcagcgatt gaaatatact tgaaattgta tgataatccc     2040

ttaaccaatg aaagcaaaca acaagaaata aactcagaaa acttgtcagc caaagaattg     2100

aagaaaatgc ttagcaagca gagaagagct cagaaaaagg ctaaactaga agaagaaaga     2160

aagcatgcag aaagagaacg tcaacagaaa aatcaaaaga aaaaaagaga tgaagaagaa     2220

gaagaagcca gtggccttaa ggaagaactt atacctgaaa aattagaaag ggtagaaaat     2280

ccattagagg aagccgttaa gttccttata cctcttaaga accttgttgc tgataacatt     2340

gacactcatc tgttagcatt tgaaatatat tttagaaaag gaaagtttct gttaatgctg     2400

cagtctgtca aacgagcttt tgccattaac agtaataacc catggttaca tgaatgttta     2460

attagatttt ctaaatctgt gtctaatcat agtaatcttc cagacattgt gagcaaagtt     2520

ctatctcaag aaatgcagaa aatatttgtc aaaaaggatt tggaaagttt taatgaggat     2580

tttctgaaac gtaacgctac ctctcttcag catctacttt caggtgctaa aatgatgtat     2640

tttctggaca agtcaaggca ggagaaagca attgctatag ccactagact agatgaaact     2700

ataaaagata aagatgtaaa gacattaata aaggtttctg aagcactgct tgatggcagc     2760

tttgggaact gtagttccca atatgaagaa tataggatgg cctgtcataa cctgcttcct     2820

tttacatctg ccttcttgcc tgctgtgaat gaagtcgaca atcctaatgt ggcactgaac     2880

catacagcta attatgatgt cttggcaaat gaaatttgaa atcttctaga aagtagactc     2940

ctatagactc aaagctgaat tgagatcagg gtttcttttc cagggtgcat tttaatatac     3000

gtatgaaatg aaatatttgg ttaggatttt taaatggcat attctgtaag cttattttgt     3060

tctttacccg acctgccaat ttacataacc atctgttaaa attacctgtt tattcttaca     3120

cagttttgtg gtagctccga tcgcttctgt ataattataa tttcttacta agctaagttg     3180

tatacaaccc cactgtatta ttttctttag attctgattt caggatctgt gctttgattc     3240

cttgtctgtt ttatcgtata tttgcttgct ttttaattaa agcacatcag ttttaaagtg     3300

ttaactatat gttaacaata tggaggctgg gcgtggtggc tcacacctgt aatcccagca     3360

ctttgggagg cccagactgg cggatcacct gaggtcagga gatcgagatc agcctggcca     3420

acatggtgaa accccttctc tactgaaaat acaaaaatta gccagacgtg atggcacata     3480

cctgtaatcc aagctgccca ggagctgagg ccggagaatc gcttgaacct gggaggtgga     3540

ggttgcagtg agccgagatc atgccactgc actccagcct gggcaacaga gcaagactcc     3600

atctcgaaaa aaaggaattc ctcttggcag atattgaagt ttatttgaaa atttaattcg     3660

tccttttttc attgtaatat ttcatggttt actatttcct tttagtattc atgaaaatgg     3720

tattttctgg ttgaataagg gtactctagt tttatgtaga tgatttcaga atgtgaaggc     3780

tggtttgcct gtcagtcatg gaaattcact ggtaaaattg ttgaatattt ctctctccca     3840

gtcttaaaag cccacaggca agaattaatg ctttcttaac taagttactt tgagtattaa     3900

caagtagctt atactgaggt gtgcttcaag ggagcattat agggcagaaa acaaattaaa     3960

atgaaatgtt gttgttatag ccatgcattg accattaaat gcattttaat atctcggcaa     4020

aatgagattt gaaactcatt agtttaactc ttaaaacata gtgttgttaa acagtatttt     4080

ttgggggcgg gtggatagct ttttgttcta tcttgtacag aaaacagtaa tggaatcact     4140

catgttcaga accttgtaaa tatgtctgta atattaatgc ttccctttat taagacaaat     4200

atacattcaa aaagggagat tttatttaga cacacatttt cttttcaccc taatctattt     4260

agattcatac ttattgagac gggaaaaact cgctgtaaaa taatgccaac ctagataatg     4320

ctataataaa ttattttgta cacagtt                                         4347


<210> 2082
<211> 2230
<212> DNA
<213> Homo sapiens

<400> 2082
ctttctgtgc tgatcttgga ggcagagtgg ctgcctgcat tcattccacg gtccattcca       60

cagcttgttc caaagacagt ctgctcatga tgtagcttct gcacttgaca aattattttc      120

atgcacgagg cccttgaaaa tgttgacagt cttgtgacat ccatggaggg ccttatttga      180

cggtcacaaa ggagcggttc ctagaaggtg agcgcggacg gtatgcaaag ttgtgaatcc      240

agtggtgaca gtgcggatga ccctctcagt cgcggcctac ggagaagggg acagcctcgt      300

gtggtggtga tcggcgccgg cttggctggc ctggctgcag ccaaagcact tcttgagcag      360

ggtttcacgg atgtcactgt gcttgaggct tccagccaca tcggaggccg tgtgcagagt      420

gtgaaacttg gacacgccac ctttgagctg ggagccacct ggatccatgg ctcccatggg      480

aaccctatct atcatctagc agaagccaac ggcctcctgg aagagacaac cgatggggaa      540

cgcagcgtgg gccgcatcag cctctattcc aagaatggcg tggcctgcta ccttaccaac      600

cacggccgca ggatccccaa ggacgtggtt gaggaattca gcgatttata caacgaggtc      660

tataacttga cccaggagtt cttccggcac gataaaccag tcaatgctga aagtcaaaat      720

agcgtggggg tgttcacccg agaggaggtg cgtaaccgca tcaggaatga ccctgacgac      780

ccagaggcta ccaagcgcct gaagctcgcc atgatccagc agtacctgaa ggtggagagc      840

tgtgagagca gctcacacag catggacgag gtgtccctga gcgccttcgg ggagtggacc      900

gagatccccg gcgctcacca catcatcccc tcgggcttca tgcgggttgt ggagctgctg      960

gcggagggca tccctgccca cgtcatccag ctagggaaac ctgtccgctg cattcactgg     1020

gaccaggcct cagcccgccc cagaggccct gagattgagc cccggggtga gggcgaccac     1080

aatcacgaca ctggggaggg tggccagggt ggagaggagc cccggggggg caggtgggat     1140

gaggatgagc agtggtcggt ggtggtggag tgcgaggact gtgagctgat cccggcggac     1200

catgtgattg tgaccgtgtc gctaggtgtg ctaaagaggc agtacaccag tttcttccgg     1260

ccaggcctgc ccacagagaa ggtggctgcc atccaccgcc tgggcattgg caccaccgac     1320

aagatctttc tggaattcga ggagcccttc tggggccctg agtgcaacag cctacagttt     1380

gtgtgggagg acgaagcaga gagccacacc ctcacctacc cacctgagct ctggtaccgc     1440

aagatctgcg gctttgatgt cctctacccg cctgagcgct acggccatgt gctgagcggc     1500

tggatctgcg gggaggaggc cctcgtcatg gagaagtgtg atgacgaggc agtggccgag     1560

atctgcacgg agatgctgcg tcagttcaca gggaacccca acattccaaa acctcggcga     1620

atcttgcgct cggcctgggg cagcaaccct tacttccgcg gctcctattc atacacgcag     1680

gtgggctcca gcggggcgga tgtggagaag ctggccaagc ccctgccgta cacagagagc     1740

tcaaagacag cgcccatgca ggtgctgttt tccggtgagg ccacccaccg caagtactat     1800

tccaccaccc acggtgctct gctgtccggc cagcgtgagg ctgcccgcct cattgagatg     1860

taccgagacc tcttccagca ggggacctga gggctgtcct cgctgctgag aagagccact     1920

aactcgtgac ctccagcctg ccccttgctg ccgtgtgctc ctgccttcct gatcctctgt     1980

agaaaggatt tttatcttct gtagagctag ccgccctgac tgccttcaga cctggccctg     2040

tagcttttct ttttctccag gctgggccgt gagcaggtgg gccgttgagt tacctctgtg     2100

ctggatcccg tgcccccact tgcctaccct ctgtcctgcc ttgttattgt aagtgccttc     2160

aatactttgc attttgggat aataaaaaag gctccctccc ctgcccctca gcttctctct     2220

ggttttctca                                                            2230


<210> 2083
<211> 636
<212> DNA
<213> Homo sapiens

<400> 2083
ggcaagatgg cgccggtggg ggtggagaag aagctgctgc taggtcccaa cgggcccgcg       60

gtggcggccg ccggcgacct gaccagtgag gaggaggaag gccagagcct atggtcctcc      120

attctgagcg aagtgtccac ccgcgccagg tccaagctgc cgtccggcaa gaacatcctg      180

gtcttcggtg aagatggttc tggtaaaaca accctcatga ctaaactaca aggagctgag      240

catggcaaaa aaggaagagg cctagaatat ctctacctca gtgtccatga tgaggaccga      300

gatgatcaca cgcgctgcaa cgtgtggatt ctggatggag acttgtacca caaaggcctg      360

ctgaaatttg cagtttctgc tgaatccttg ccagagaccc tcgtcatttt tgttgcagac      420

atgtctagac cttggactgt gatggaatct ctgcagaaat gggctagtgt tttacgtgag      480

cacattgata aaatgaaaat tccaccagaa aaaatgaggg agctggaacg gaagtttgtg      540

aaagattttc aagactatat ggaacctgaa gaaggttgtc aagagggccc actttctaac      600

agggtggagc aaatgagacc aagaaatcat tggtaa                                636


<210> 2084
<211> 1243
<212> DNA
<213> Homo sapiens

<400> 2084
aactggaatc ttgcctcctg gaatccttca aatcctgaat gtctcttact tgtggtgaag       60

gaacttgtgc aacaatatca ccaattccaa tgtagccgcc tccgggagag ctcccgcctc      120

atgtttgaat accagacatt actggaggag ccacagtatg gagagaacat ggaaatttat      180

gctgggaaaa aaaacaactg gactggtgaa ttttcagctc gtttcctttt gaagctgccc      240

gtagatttca gcaatatccc cacatacctt ctcaaggatg taaatgaaga ccctggagaa      300

gatgtggccc tcctctctgt tagttttgag gacactgaag ccacccaggt gtaccccaag      360

ctgtacttgt cacctcgaat tgagcatgca cttggaggct cctcagctct tcatatccca      420

gcttttccag gaggaggatg tctcattgat tacgttcctc aagtatgcca cctgctcacc      480

aacaaggtgc agtacgtgat tcaagggtat cacaaaagaa gagagtatat tgctgctttt      540

ctcagtcact ttggcacagg tgtcgtggaa tatgatgcag aaggctttac aaaactcact      600

ctgctgctga tgtggaaaga tttttgtttt cttgtacaca ttgacctgcc tctgtttttc      660

cctcgagacc agccaactct cacatttcag tccgtttatc actttaccaa cagtggacag      720

ctttactccc aggcccaaaa aaattatccg tacagcccca gatgggatgg aaatgaaatg      780

gccaaaagag caaaggctta tttcaaaacc tttgtccctc agttccagga ggcagcattt      840

gccaatggaa agctctagga aacaccagtc ttgagaggtg gccagccaga ctgcctgtcc      900

acatgcgtgt cagcacatac agccgcttcc tggaagccgc ctggaatgtc ttcacggcag      960

cgttttgctc acacagcagc ttttgcacgc cccaggcagc cccgactgct gaaatccaac     1020

ttgagctggc tggtggtccc tggatcctag agcccttcac ttcgggttac tccctctttc     1080

ttgcctctat ttcttagttg gaagaaataa actcacaaat tatggtgcag taattttccg     1140

gggaaagtaa agcctcagga atgcccacgc ctttcttcca aagcctttgt ctctgagacc     1200

tcttaagttc taagattaaa tgcccctcgc tgttcttcct ctg                       1243


<210> 2085
<211> 1657
<212> DNA
<213> Homo sapiens

<400> 2085
gcggcgcgcg cgcaggtcgg tgcgtctgtc gggggcgcgc tcgggtacct gtaccccacg       60

tagtcgccgg ttaccgatcg gactaagttc cagtggtgat ttacaagtca agttaaaatg      120

tccccagaag tggccttgaa ccgaatatct ccaatgctct cccctttcat atctagcgtg      180

gtccggaatg gaaaagtggg actggatgct acaaactgtt tgaggataac tgacttaaaa      240

tctggctgca catcattgac tcctgggccc aactgtgacc gatttaaact gcacatacca      300

tatgctggag agacattaaa gtgggatatc attttcaatg cccaataccc agaactgcct      360

cccgatttta tctttggaga agatgctgaa ttcctgccag acccctcagc tttgcagaat      420

cttgcctcct ggaatccttc aaatcctgaa tgtctcttac ttgtggtgaa ggaacttgtg      480

caacaatatc accaattcca atgtagccgc ctccgggaga gctcccgcct catgtttgaa      540

taccagacat tactggagga gccacagtat ggagagaaca tggaaattta tgctgggaaa      600

aaaaacaact ggactggtga attttcagct cgtttccttt tgaagctgcc cgtagatttc      660

agcaatatcc ccacatacct tctcaaggat gtaaatgaag accctggaga agatgtggcc      720

ctcctctctg ttagttttga ggacactgaa gccacccagg tgtaccccaa gctgtacttg      780

tcacctcgaa ttgagcatgc acttggaggc tcctcagctc ttcatatccc agcttttcca      840

ggaggaggat gtctcattga ttacgttcct caagtatgcc acctgctcac caacaaggtg      900

cagtacgtga ttcaagggta tcacaaaaga agagagtata ttgctgcttt tctcagtcac      960

tttggcacag gtgtcgtgga atatgatgca gaaggcttta caaaactcac tctgctgctg     1020

atgtggaaag atttttgttt tcttgtacac attgacctgc ctctgttttt ccctcgagac     1080

cagccaactc tcacatttca gtccgtttat cactttacca acagtggaca gctttactcc     1140

caggcccaaa aaaattatcc gtacagcccc agatgggatg gaaatgaaat ggccaaaaga     1200

gcaaaggctt atttcaaaac ctttgtccct cagttccagg aggcagcatt tgccaatgga     1260

aagctctagg aaacaccagt cttgagaggt ggccagccag actgcctgtc cacatgcgtg     1320

tcagcacata cagccgcttc ctggaagccg cctggaatgt cttcacggca gcgttttgct     1380

cacacagcag cttttgcacg ccccaggcag ccccgactgc tgaaatccaa cttgagctgg     1440

ctggtggtcc ctggatccta gagcccttca cttcgggtta ctccctcttt cttgcctcta     1500

tttcttagtt ggaagaaata aactcacaaa ttatggtgca gtaattttcc ggggaaagta     1560

aagcctcagg aatgcccacg cctttcttcc aaagcctttg tctctgagac ctcttaagtt     1620

ctaagattaa atgcccctcg ctgttcttcc tctgaaa                              1657


<210> 2086
<211> 1752
<212> DNA
<213> Homo sapiens

<400> 2086
ggtacctgta ccccacgtag tcgccggtta ccgatcggac taagttccag aagcaagaga       60

taaagtaata atgggtactg tggggaaaaa cacagaagaa caattcggta atatagtggt      120

gatttacaag tcaagttaaa atgtccccag aagtggcctt gaaccgaata tctccaatgc      180

tctccccttt catatctagc gtggtccgga atggaaaagt gggactggat gctacaaact      240

gtttgaggat aactgactta aaatctggct gcacatcatt gactcctggg cccaactgtg      300

accgatttaa actgcacata ccatatgctg gagagacatt aaagtgggat atcattttca      360

atgcccaata cccagaactg cctcccgatt ttatctttgg agaagatgct gaattcctgc      420

cagacccctc agctttgcag aatcttgcct cctggaatcc ttcaaatcct gaatgtctct      480

tacttgtggt gaaggaactt gtgcaacaat atcaccaatt ccaatgtagc cgcctccggg      540

agagctcccg cctcatgttt gaataccaga cattactgga ggagccacag tatggagaga      600

acatggaaat ttatgctggg aaaaaaaaca actggactgg tgaattttca gctcgtttcc      660

ttttgaagct gcccgtagat ttcagcaata tccccacata ccttctcaag gatgtaaatg      720

aagaccctgg agaagatgtg gccctcctct ctgttagttt tgaggacact gaagccaccc      780

aggtgtaccc caagctgtac ttgtcacctc gaattgagca tgcacttgga ggctcctcag      840

ctcttcatat cccagctttt ccaggaggag gatgtctcat tgattacgtt cctcaagtat      900

gccacctgct caccaacaag gtgcagtacg tgattcaagg gtatcacaaa agaagagagt      960

atattgctgc ttttctcagt cactttggca caggtgtcgt ggaatatgat gcagaaggct     1020

ttacaaaact cactctgctg ctgatgtgga aagatttttg ttttcttgta cacattgacc     1080

tgcctctgtt tttccctcga gaccagccaa ctctcacatt tcagtccgtt tatcacttta     1140

ccaacagtgg acagctttac tcccaggccc aaaaaaatta tccgtacagc cccagatggg     1200

atggaaatga aatggccaaa agagcaaaaa gagagagcaa cagagatggg gaggaatcca     1260

gctctgcctg acatccaggc atcctctcca aattgcatag ggcttatttc aaaacctttg     1320

tccctcagtt ccaggaggca gcatttgcca atggaaagct ctaggaaaca ccagtcttga     1380

gaggtggcca gccagactgc ctgtccacat gcgtgtcagc acatacagcc gcttcctgga     1440

agccgcctgg aatgtcttca cggcagcgtt ttgctcacac agcagctttt gcacgcccca     1500

ggcagccccg actgctgaaa tccaacttga gctggctggt ggtccctgga tcctagagcc     1560

cttcacttcg ggttactccc tctttcttgc ctctatttct tagttggaag aaataaactc     1620

acaaattatg gtgcagtaat tttccgggga aagtaaagcc tcaggaatgc ccacgccttt     1680

cttccaaagc ctttgtctct gagacctctt aagttctaag attaaatgcc cctcgctgtt     1740

cttcctctga aa                                                         1752


<210> 2087
<211> 2534
<212> DNA
<213> Homo sapiens

<400> 2087
atgatccgag cttttccaac aactacccca cgcagtcttc atctcttcac ttcatctact       60

ttcctggctc gcgcccttcc aggagccttt cccaccggag cctgcgagga gagactcagt      120

gttcctgaaa gtacaccttt cacagcagtc ttaaagtttg cagcagaaga atttaaagtt      180

cctgctgcaa caagtgcaat tattaccaat gatggaatag gaataaatcc tgcacagact      240

gctggaaatg tttttctaaa acatggttca gaactgcgga ttattcctag agatcgtgtt      300

ggaagttgtt aatatctgct acttggaaca tacgattgcc tttcagaata aatattggta      360

ttttttgttg ttgtaaaatt gaaatcaggc atttaacata ctatgaaaac accaggagtc      420

aatgattaat gaaaggtgac tcatctgtcc ctttttgttg tccatactct tcctatgaag      480

agggaatgcg tatgaattaa ggctactact gtcacagaag atcatagtct ttgatgctac      540

ctcacaacac aaacaggtag ttcgttgggg gcaaatgaat tagccaactg ttaactggaa      600

gcttttgata attttttttt ttagaacaat ttggaacatt aaaatttact gaatcgtata      660

tattcatctg agataaaaat ataaaaagaa ttatggaccc tggatggcaa tttgcttgat      720

agcatctgat ttgcagactc ataatttgat ttttaattaa atatataggt tgtgatgaag      780

tgaatagaca tatcagtgaa cagttaacta tattaaattt ttatcattta ctttttttaa      840

gattcagacc tcagttatat aaatttcagt ttaatatcaa ccaaaaaatt aaaattttaa      900

tctaaccctt atgtgtataa attggtgtcc cataccagct tttaatggtg gacctataga      960

atccagtact tttaatggtg ggaatttaca gtagaagcat cctttgctga gttatacatt     1020

cctttatcaa tctcttttga tacaacattt aaaacaagta gcttcaagaa accactggtg     1080

ttttgaggat agtatttcta aatagcattc aggaacagag tattattgca cagatctgaa     1140

gatcaaaaaa aagctcaagg aaatacagat cggaagtgct gatgagttat atttattgaa     1200

aacccaactt ttaaggaagt gctaagatca gtcacccatg tgaataagaa gccaggaaag     1260

gaaagatggg gaagcccaga tcaccaggct tctattaagg aggaaagcaa cagaggaaac     1320

agtgaagggg aacagaaggg ggtagcaaag tgttacagaa aagcggactg gatagacaaa     1380

actgcagaag gtgtatgttg gggagaactg aaagggaaaa caaaatactt gacatagtct     1440

taagtagaag aaggcagtta gagaaaacaa agtatctact ggccttgtca acatacagac     1500

ttcaaaatac cccttatgag aatccaaaga atgatgtgtg taagggaaga ttttatttgc     1560

ccttccggaa gaaatcagta tctatgcaaa tcttgaaaga cgaaatcaaa gcccattaat     1620

gattcagaat cagtgcttga cctcctgtat tctgaatggt gaactctgga agcagggatt     1680

gtgtctggct ctttttagag ctggaaatgt agtggctttc attaaatact tgctgtaaag     1740

tctttctaag accaattatt atcttagcat gtttcagtat cttctctatc ataggcccta     1800

agttcattgg gggaaaaaaa ataagaagat tcaacagaat cagcatttga agtgtaccat     1860

tggtagttgt ttatgaaatt accagatatt cataaatgtg acaaatgaac agcaggatta     1920

tgaattatca aaggaaaaag tatttgctga ggtgaaaaaa tctgatgttt gaggaagttt     1980

ttatttttat ttatttgttt tgtttttttt tttttgaggc agactctctg tcgccaggct     2040

tctcctgcct cagcctcacg agtagctggg actacaggca tgcaccacca cgcccagcta     2100

atttttgtat ttttagcaga gacagggagg aagtttttat ttttataaac aaaatctgat     2160

gttcagaggc cccgtttctt acaataaatg ttgagtctta gttaagcagg aatttatgaa     2220

cacccatttc ctgacttttt gctttaattt agatttttct ccatcctgtt tctagcacaa     2280

aaatttgcct gctgtgttac aaaaataaat ttatgttgtc ctgtgccata aagtgatata     2340

tttaatattt ttattctttg gttttgaaca ttgtaagttc ctaaaaacat tttattaaac     2400

aagtagacat tttgttatta aaaaaatgtg atctgtaatt tctttgtgca gaatgatttg     2460

aagtattgta ttcagtttac atgcgttatt ggtttataat taatatctaa tgaaaataca     2520

tgttgttata ttgt                                                       2534


<210> 2088
<211> 2664
<212> DNA
<213> Homo sapiens

<400> 2088
gggctctgag ccggaggttt tgttgtgagg gtcggttgtc aagcagcggc caatcaaggc       60

aggggatgga ggcaagtggg ggtcgcgcct ggagcggagc ctcggcctcc ggagccgcag      120

ctgcagccct gtattgagct gagatggctc gagcctaaca ttccatgatc caggatcgtg      180

acagatgtgc acaggctgct gctgttgctg ctgtgggtaa tttggaacca cgaggcaccc      240

cagggccaga agacgaggca ttctgtctgc ctggatgtgt gggaactctc tgccaacttg      300

attggtggat ctgggggggg atccaccccc accccacgag gaaagcacag tttattttgt      360

gggtggggct tcaggtgcca gccagctgaa ggatggccac ccctgtggtc accaagacag      420

cctggaagtt gcaagagatc gtcgcgcatg ccagcaacgt gtcctcactg gtgctgggca      480

aagcctccgg gcggctgctg gctacaggcg gggatgactg ccgcgtcaac ctgtggtcca      540

tcaacaagcc caactgcatc atgagcctga cgggccacac atccccagtg gagagcgtcc      600

gcctcaacac ccccgaggag ctcatcgtgg ccggctctca gtcgggctcc atccgtgtct      660

gggacctgga agctgccaaa attcttcgca cactcatggg acacaaagcc aacatctgca      720

gcctggattt ccacccgtac ggcgagtttg tagcctctgg ttcccaggac acaaacatca      780

agctctggga catcaggagg aaaggctgtg tcttccgata cagggggcac agccaggccg      840

tgcggtgtct ccggttcagc cccgatggga agtggttggc gtcggccgca gatgaccaca      900

ccgtgaagct ctgggatctc actgccggca agatgatgtc tgagttccct ggtcacacgg      960

ggcctgtcaa cgtggtcgag tttcacccca acgagtacct cctggcctcc ggcagctctg     1020

acaggacaat ccgcttctgg gacctggaga agttccaggt ggtgagctgc atcgaagggg     1080

agcctgggcc cgtcaggagc gtcctcttca acccagacgg ctgctgcctg tacagcggct     1140

gccaggactc actgcgtgtc tacggctggg aacctgagcg gtgctttgat gtggtcctcg     1200

tcaactgggg caaggtggcc gacctggcca tctgcaatga ccagttgata ggtgtggcct     1260

tctcccagag caacgtctcc tcctacgtgg tggatctgac gcgtgtcacc aggactggca     1320

cggtggcccg ggaccctgtg caggaccacc ggcccctggc acagccactg cccaacccca     1380

gcgcccccct ccggcgcatc tatgagcggc ccagcacaac ctgcagcaag cctcagaggg     1440

tgaagcagaa ctcagagagc gagcgccgca gccccagcag cgaggatgac cgggacgagc     1500

gcgagtcccg cgcggagatc cagaacgccg aggactacaa cgagatcttc cagcccaaga     1560

acagcatcag tcggacgcca ccccggagaa gtgagccctt ccctgcaccc ccagaggacg     1620

acgcagccac agcaaaggag gcagcaaagc ccagccctgc catggatgtg cagttcccgg     1680

tgccaaatct ggaggtcctg ccccggcccc cagtggttgc ttccacacct gcacccaagg     1740

ctgagcctgc catcatccct gccacccgga acgagcccat cgggctgaag gcctccgact     1800

tcctgcccgc cgtgaagatc ccccagcagg ccgagctggt ggacgaggat gccatgtcac     1860

agatccgcaa aggccacgac accatgtgtg tggtgctcac cagccgccac aagaacctgg     1920

acactgtgcg ggctgtgtgg accatgggcg acatcaagac gtcggtggac tccgctgtgg     1980

ccatcaacga cctgtcggtg gtggtggacc tcctgaacat cgtcaaccag aaagcctccc     2040

tgtggaagct ggacctgtgc accaccgtcc tgccacagat tgagaagctt ctgcagagca     2100

agtatgagag ctacgtccag acgggctgca cctccctgaa gctgatcctg cagcggtttc     2160

tgcccctcat cacagacatg ctggcggccc caccctctgt gggtgtggat atcagcaggg     2220

aggagaggct gcataagtgc cggctctgct acaagcagct taagagcatc agcggcctgg     2280

tcaagagcaa gtcaggcctg agcggccgcc atggcagtac cttccgcgag ctgcacctgc     2340

tcatggccag tctggactga ggaaagcagt gggcaggggc gctcggcagc ccacagggcc     2400

tggcctcagc ccccactcct gttccttgtg cacccactgg cccatgagcc tctgcctggc     2460

ccctgctgct gtcctgtggc cgtcctggag gaggtgatgc tggtccctgg ccacctctac     2520

agccctgaac tcttgagaca actctctcca gcaatagctg cccagctttg cccaactgtt     2580

gcttcttggg gcagcgaact gagccctggg gctgctgctg taatttataa ggcaaatttt     2640

attaaatttg taactattcc cagg                                            2664


<210> 2089
<211> 404
<212> DNA
<213> Homo sapiens

<400> 2089
gcagttgttg ttggttgggg gccttttggc cggtgacgga gactgcccag gtgtggtcac       60

catgttcctc tccgcggtct tctttgccaa gagcaagtca aatgaaacaa agagtcctct      120

tcgtggaaaa gaaaaaaata cgctcccttt aaacggtgga ttgaaaatga ctttgattta      180

taaagagaag actgagggcg gggatactga ttcagaaatc ctgtagcgtg taataaaaga      240

agaggaaatg gcatggaatc actgcctcct gtgatttgaa ggccattgtg aaggaaaaca      300

atgcagtgaa agaaagttct tcatattagg acagatatca ttgcatcaca tttatttatc      360

tttctgggta tttttatagc ccttaataaa aaatattaaa atag                       404


<210> 2090
<211> 4255
<212> DNA
<213> Homo sapiens

<400> 2090
gactcccggg tccccgcgcc ggactgggac tgggagcagg cagcccgggc ggagcgggcc       60

ggtgccgagg acggccccag gcattgctct gccccgggca ttgcgcggcg cgcgtgaggg      120

ggatgcggca ggaggcggcg cggcgggagg agtaggcggc ggcgccctcg ggagggagct      180

gcgcgcgggc cagacggcgc ccggaggctc cgcagtgccg ccgccgtcgc ccgggaggct      240

ccgcgcggga gccatgtaac cctgcggcgg gctccgggct gctccgtcct tccccagctc      300

ccgggctagc gcggcagcgg ggccacgatg aagaagcagt tcaatcgcat gcgccagctg      360

gccaaccaga cggtgggcag ggctgaaaag acagaagttt tgagtgaaga ccttcttcag      420

gtggagaagc gtctggagct ggtgaaacag gtgtcccaca gcacgcacaa gaagctcacc      480

gcatgtctgc agggccagca aggggcagag gctgacaagc gctccaaaaa gttgcctttg      540

acaacactgg ctcagtgtct gatggagggg tcagctatcc tgggagatga cacacttctt      600

gggaagatgc tgaaactctg tggagagacg gaggacaagc tggctcagga gctgatacat      660

tttgagttgc aagtagagag agacgtgatt gagcccctgt ttttgctggc ggaggtggaa      720

atcccaaata ttcaaaagca gaggaaacac ttagccaagt tggtgctgga catggattcc      780

tcacgaacca ggtggcagca gacttccaag tcttcaggtt tgtccagcag cttacagcct      840

gcgggtgcca aggctgatgc cctcagggaa gaaatggaag aggctgccaa cagagtggag      900

atttgcaggg accagctctc agctgatatg tacagttttg tggccaaaga aattgactat      960

gcaaactact ttcaaacgct aatagaagtg caagctgaat accacaggaa gtccctgaca     1020

ctattgcagg ctgtattgcc tcagatcaaa gcacaacagg aggcctgggt agagaagcct     1080

tccttcggga agccgctgga ggagcacctc accatcagcg gccgggagat cgccttcccc     1140

atcgaggcgt gtgtgaccat gctgcttgag tgtgggatgc aggaggaggg actcttccga     1200

gtagccccct ctgcctccaa actgaagaag ctgaaagcgg ccctggactg ctgcgtggtg     1260

gatgtgcagg agtactcggc agacccccac gcaattgcag gagctttgaa atcttacctc     1320

cgagagttgc cagaacctct tatgaccttt gaactctatg atgagtggat ccaggcttcc     1380

aatgtccagg agcaagacaa gaagcttcag gctctatgga atgcttgtga aaagttgccc     1440

aaggccaatc acaacaacat ccgatacttg ataaaatttt tatccaagct gtcagaatat     1500

caagatgtaa acaagatgac tcccagtaat atggcaattg ttttaggacc caacctccta     1560

tggccacaag cagaagggaa cattacagag atgatgacca cagtgtcgct gcaaattgtt     1620

gggatcattg aacctatcat ccagcatgca gactggttct tccctgggga gatagagttc     1680

aacattactg gcaattatgg gagtccagta cacgtgaacc ataatgccaa ctacagctca     1740

atgccctccc cagacatgga ccctgctgac cggcgccagc ccgagcaggc ccgccggccc     1800

ctcagcgtcg ccacggataa tatgatgctg gagttttaca aaaaggatgg ccttaggaaa     1860

atccaaagca tgggtgtgag ggtcatggac acaaactggg tggctcgaag aggctcctcg     1920

gccggtcgga aagtgtcctg cgccccgccc tccatgcagc ctcccgcccc gcccgccgag     1980

ctggctgcgc ccctgccttc gccgctgccg gagcagcccc tggacagccc cgcggccccc     2040

gcgctctctc catccggcct gggcctccag cctgggcccg agcgcaccag cacaacaaaa     2100

agcaaggaac tttctccagg ctctgcacag aaaggaagtc caggctccag ccagggcaca     2160

gcctgtgcag ggactcaacc aggggctcaa cctggagctc agccgggcgc cagccccagc     2220

cccagccagc cgcctgcaga ccagagtcct cacaccctcc ggaaagtttc aaagaagctg     2280

gcaccgattc cacccaaggt cccctttggc cagccggggg ctatggcaga ccagtccgct     2340

ggccagccgt ccccagtcag cctgtccccc accccgccca gcaccccgtc accctatgga     2400

ctgagctacc ctcaggggta ctccttggcc tcgggccagc tctccccagc tgcagctcct     2460

cccctggcct ctccttctgt ctttacaagc actttgagca aatcgcggcc cactcctaag     2520

ccgcgacaga gacctactct gccgcctcct cagcctccca cagtaaacct ctcggcctct     2580

agtccacagt ccacggaggc ccccatgcta gatggcatgt cccctgggga aagcatgtct     2640

acagatcttg tccactttga tattccctcg atccacatag agctcgggtc gacgctccgc     2700

ctgagtcccc tggagcacat gcggcgacac tcagtaactg acaagaggga ctcggaggag     2760

gagtctgaga gcaccgccct ctgacatgac accgcccatc ctgcctcgcg tgtacataca     2820

tcacgggccc taggaacgcc gccaggagca gcgtccatga gcttgccaag tgttctctgc     2880

tggctctttc ctgccactgc caacacgagg ttggaatttg gcagaaaatt gtgatctcca     2940

gtccgtgtgg tgatgctggt ggtgcaggtt ttgtttgttc ctttcgggtg gtgacttcgg     3000

ccttttgttt gacctttgcc ttttgacttt gtgcctcttt tgatccactt tcagcctcca     3060

tgccagaaaa cacccacctc tccatccaag gctggtcagg aacgtccttt gcagggtcgg     3120

ggtggtgcgg gagaggctca ctttgcctgg ttagacccaa gggctgctac cttttccttg     3180

gacggctcat gtcaggtctt gcaggatcag tttaatggcc acagaaagga agcaggacag     3240

cagggcccct ctcacccaca actggaccag gtccaggatt ctagcagtcc tggggcactg     3300

acctttgcca gctacctggg ggagggcttg ccactggaaa acctttcagg ccgcccccat     3360

cagtgggctc caaagtaaat ggctgaaaac aaaaatgttt cacttcctaa cagttttcct     3420

ttttccactg tgtgactgaa agctcctata tcattttata tttctgaatc tataaaacaa     3480

aacaaacaag cctgacagtg tctggaggag ccaaaggtgg cctccctgtc cccaaatata     3540

ttggctatat gagagtaatt ttacccctct acgtacctaa aggcacccag ttcactagtc     3600

tgtggggtcc tggagcctgt ctcttctttc tggaggttca aactgaatag caataattac     3660

gttacccaaa gcatgtggag gaaaagtgaa accagccacg gagacgctgg cccacgggct     3720

cggcctgcgg tgtggcctgc tttgctcacc agcgtcagcc gctcatttcc ttctcatgaa     3780

gtcccatctg gtcatgggga cgagggccgg gagggcaccg ggtagccttt tcacacttgg     3840

ggattagggg agtgagaaaa gatttgggcc atgcatgcaa agtcaaagtt taaaatttta     3900

tccttttcaa atagatgata taatatacct atacatgata taatatttgt atatatgaaa     3960

tctctctata tttgtttaat ttgagccatt caatctaaac caatgtacag gtgtacaatg     4020

aaaaatttaa atgcttagtt atttttccca acacagtgta aagtcaccct cctctgagag     4080

tgggatgtgc agagttttga tgttgcagct ttgctcactt cctggcaagg gcaggtcatg     4140

cctcaatttg taatgggagt ctggggtaag ggtgggggtt gaaagttgtt atctttaaat     4200

acatgtacaa atcgttgtca aaagtaacgt tattaaaata gatttattat ccctg          4255


<210> 2091
<211> 2406
<212> DNA
<213> Homo sapiens

<400> 2091
gatttgtggt tggctgaggt ggaggaacaa aatggcggcg ccggcggcgt gaccgggccc       60

tctggcccac agccgttggt agcggtggca gcagtactgc tgccccaact cgctgtgccc      120

cctttctcag cccacgacat cgccacgaca gcgaggcagc gaccgccacc gagaaagagg      180

tggtggccca gcctggaacc ttgagaaacc ctcgcaaact gtggcctggc ggaaatcctg      240

gtgtgctgca gggatcaggc tgactccacg ccctgtaaca ccgggaaacg cctcggtggc      300

catttccagc agccctcatc ctcagccttg cgggccggtg ggccccggag gcctccatcc      360

tcccctagag gggtcagggc tgagcccagc ctccatcttt gcctctcagg atgacaaaca      420

acagcggctc caaagccgaa ctcgttgtgg gagggaaata caaactggtg cggaagatcg      480

ggtctggctc ctttggagac gtttatctgg gcatcaccac caccaacggc gaggacgtag      540

cagtgaagct ggaatctcag aaggtcaagc acccccagtt gctgtatgag agcaaactct      600

acacgattct tcaaggtggg gttggcatcc cccacatgca ctggtatggt caggaaaaag      660

acaacaatgt gctagtcatg gaccttctgg gacccagcct cgaagacctc tttaatttct      720

gttcaagaag gttcaccatg aaaactgtac ttatgttagc cgaccagatg atcagcagaa      780

ttgaatacgt gcatacaaag aattttctac accgagacat taaaccagat aacttcctga      840

tgggtactgg gcgtcactgt aataagttgt tccttattga ttttggtttg gccaaaaagt      900

acagagacaa caggaccagg caacacatac cgtacagaga agataaacac ctcattggca      960

ctgtccgata tgccagcatc aatgcacatc ttggtattga gcagagccgc cgagatgaca     1020

tggaatcctt aggctacgtt ttcatgtatt ttaatagaac cagcctgccg tggcaaggac     1080

taagggctat gacaaaaaaa caaaaatatg aaaagattag tgagaagaag atgtccaccc     1140

ctgttgaagt tttatgtaag gggtttcctg cagaattcgc catgtacttg aactactgtc     1200

gtgggctgcg ctttgaggaa gtcccagatt acatgtatct gaggcagcta ttccgcattc     1260

ttttcaggac cctgaaccac caatatgact acacatttga ttggacgatg ttaaagcaga     1320

aagcagcaca gcaggcagcc tcttccagtg ggcagggtca gcaggcccaa acccagacag     1380

gcaagcaaac tgaaaaaaac aagaataatg tgaaagataa ctaagcgtga atgaggaaca     1440

gaagaagcag agcagatgat tcgagcagca tttgtttctc cccacatcta gaaattgtag     1500

ttcatatgta caccagctag tggctgtgaa caaccattta gttggtgtaa aaaactttat     1560

ttcaatataa actgactctg gggagcgttg gtgatgctgt atcccaaagt gtagcctctg     1620

taattgtgaa tattaactga ggtagtgaaa cgtggtgtct ggttttctat tgcatttatt     1680

caagtagaaa agttaactaa atggttgaca cacacgaatt ggtggagaca ttgtccatat     1740

gccaattttt tgttaaaacc ttttattttg aactagactg ctttgagata tcatttcaga     1800

aggacagtat tcagccacag ctgcaaaggt tgtaaatgct tatgattgag catttttagg     1860

gtttctccat ccctggggtt tgcaaattgt tcacataaag agcattctta aaatggttgg     1920

cttcttgtct gtaagccagc tgatctagta gtaaccaaaa attccagttt tgagaatagg     1980

aaagattccg cctgcttacc tgtgaagaca taagaaaatc ttagtaacta ccagattatc     2040

tttagaattc cacattaact atatcatgtt ctcggtattt taaaaacaac aacaaccata     2100

tttgtcacag aaatttagtt aacatcttac aactgaacat gtatgtacat ggcttagata     2160

aatgtaatca ccgtaaacac ccatatgatc tgggattttg ttcatatttt gaaatgggag     2220

cttttatgtt ttacaagttc actaaaatct gaaaactgtt tctataagga aataatactt     2280

ttttaaacaa caaccaaaaa atgccttgct gattcactag gaaataaaaa tctccccaat     2340

tttttgatag tcaacttcga gccatttgtt acatgatatt cccttgcaag taaattttat     2400

ttcatt                                                                2406


<210> 2092
<211> 2163
<212> DNA
<213> Homo sapiens

<400> 2092
gcggagcgca gctgtgaggg agtcgctgtg atccggggcc ccggaacccg agctggagct       60

gaagcgcagg ctgcggggcg cggagtcggg aggcctgagt gttccttcca gcatgtcgga      120

gggggagtcc cagacagtac ttagcagtgg ctcagaccca aaggtagaat cctcatcttc      180

agctcctggc ctgacatcag tgtcacctcc tgtgacctcc acaacctcag ctgcttcccc      240

agaggaagaa gaagaaagtg aagatgagtc tgagattttg gaagagtcgc cctgtgggcg      300

ctggcagaag aggcgagaag aggtgaatca acggaatgta ccaggtattg acagtgcata      360

cctggccatg gatacagagg aaggtgtaga ggttgtgtgg aatgaggtac agttctctga      420

acgcaagaac tacaagctgc aggaggaaaa ggttcgtgct gtgtttgata atctgattca      480

attggagcat cttaacattg ttaagtttca caaatattgg gctgacatta aagagaacaa      540

ggccagggtc atttttatca cagaatacat gtcatctggg agtctgaagc aatttctgaa      600

gaagaccaaa aagaaccaca agacgatgaa tgaaaaggca tggaagcgtt ggtgcacaca      660

aatcctctct gccctaagct acctgcactc ctgtgacccc cccatcatcc atgggaacct      720

gacctgtgac accatcttca tccagcacaa cggactcatc aagattggct ctgtggctcc      780

tgacactatc aacaatcatg tgaagacttg tcgagaagag cagaagaatc tacacttctt      840

tgcaccagag tatggagaag tcactaatgt gacaacagca gtggacatct actcctttgg      900

catgtgtgca ctggagatgg cagtgctgga gattcagggc aatggagagt cctcatatgt      960

gccacaggaa gccatcagca gtgccatcca gcttctagaa gacccattac agagggagtt     1020

cattcaaaag tgcctgcagt ctgagcctgc tcgcagacca acagccagag aacttctgtt     1080

ccacccagca ttgtttgaag tgccctcgct caaactcctt gcggcccact gcattgtggg     1140

acaccaacac atgatcccag agaacgctct agaggagatc accaaaaaca tggatactag     1200

tgccgtactg gctgaaatcc ctgcaggacc aggaagagaa ccagttcaga ctttgtactc     1260

tcagtcacca gctctggaat tagataaatt ccttgaagat gtcaggaatg ggatctatcc     1320

tctgacagcc tttgggctgc ctcggcccca gcagccacag caggaggagg tgacatcacc     1380

tgtcgtgccc ccctctgtca agactccgac acctgaacca gctgaggtgg agactcgcaa     1440

ggtggtgctg atgcagtgca acattgagtc ggtggaggag ggagtcaaac accacctgac     1500

acttctgctg aagttggagg acaaactgaa ccggcacctg agctgtgacc tgatgccaaa     1560

tgagaatatc cccgagttgg cggctgagct ggtgcagctg ggcttcatta gtgaggctga     1620

ccagagccgg ttgacttctc tgctagaaga gaccttgaac aagttcaatt ttgccaggaa     1680

cagtaccctc aactcagccg ctgtcaccgt ctcctcttag agctcactcg ggccaggccc     1740

tgatctgcgc tgtggctgtc cctggacgtg ctgcagccct cctgtccctt ccccccagtc     1800

agtattaccc tgtgaagccc cttccctcct ttattattca ggagggctgg gggggctccc     1860

tggttctgag catcatcctt tcccctcccc tctcttcctc ccctctgcac tttgtttact     1920

tgttttgcac agacgtgggc ctgggccttc tcagcagccg ccttctagtt gggggctagt     1980

cgctgatctg ccggctcccg cccagcctgt gtggaaagga ggcccacggg cactagggga     2040

gccgaattct acaatcccgc tggggcggcc ggggcgggag agaaaggtgg tgctgcagtg     2100

gtggccctgg ggggccattc gattcgcctc agttgctgct gtaataaaag tctacttttt     2160

gct                                                                   2163


<210> 2093
<211> 4089
<212> DNA
<213> Homo sapiens

<400> 2093
acagcctgcg gggaacgtag ctagctgcaa gcagaggccg gcatgaccac cgagcagcga       60

cgcagcctgc aagccttcca ggattatatc cggaagaccc tggaccctac ctacatcctg      120

agctacatgg ccccctggtt tagggaggaa gaggtgcagt atattcaggc tgagaaaaac      180

aacaagggcc caatggaggc tgccacactt tttctcaagt tcctgttgga gctccaggag      240

gaaggctggt tccgtggctt tttggatgcc ctagaccatg caggttattc tggactttat      300

gaagccattg aaagttggga tttcaaaaaa attgaaaagt tggaggagta tagattactt      360

ttaaaacgtt tacaaccaga atttaaaacc agaattatcc caaccgatat catttctgat      420

ctgtctgaat gtttaattaa tcaggaatgt gaagaaattc tacaggtata aaagatgttg      480

aaacagaaga tcttgaggat aagatggaaa cttctgacat acagattttc taccaagaag      540

atccagaatg ccagaatctt agtgagaatt catgtccacc ttcagaagtg tctgatacaa      600

acttgtacag cccatttaaa ccaagaaatt accaattaga gcttgctttg cctgctatga      660

aaggaaaaaa cacaataata tgtgctccta caggttgtgg aaaaaccttt gtttcactgc      720

ttatatgtga acatcatctt aaaaaattcc cacaaggaca aaaggggaaa gttgtctttt      780

ttgcgaatca gatcccagtg tatgaacagc agaaatctgt attctcaaaa tactttgaaa      840

gacatgggta tagagttaca ggcatttctg gagcaacagc tgagaatgtc ccagtggaac      900

agattgttga gaacaatgac atcatcattt taactccaca gattcttgtg aacaacctta      960

aaaagggaac gattccatca ctatccatct ttactttgat gatatttgat gaatgccaca     1020

acactagtaa acaacacccg tacaatatga tcatgtttaa ttatctagat cagaaacttg     1080

gaggatcttc aggcccactg ccccaggtca ttgggctgac tgcctcggtt ggtgttgggg     1140

atgccaaaaa cacagatgaa gccttggatt atatctgcaa gctgtgtgct tctcttgatg     1200

cgtcagtgat agcaacagtc aaacacaatc tggaggaact ggagcaagtt gtttataagc     1260

cccagaagtt tttcaggaaa gtggaatcac ggattagcga caaatttaaa tacatcatag     1320

ctcagctgat gagggacaca gagagtctgg caaagagaat ctgcaaagac ctcgaaaact     1380

tatctcaaat tcaaaatagg gaatttggaa cacagaaata tgaacaatgg attgttacag     1440

ttcagaaagc atgcatggtg ttccagatgc cagacaaaga tgaagagagc aggatttgta     1500

aagccctgtt tttatacact tcacatttgc ggaaatataa tgatgccctc attatcagtg     1560

agcatgcacg aatgaaagat gctctggatt acttgaaaga cttcttcagc aatgtccgag     1620

cagcaggatt cgatgagatt gagcaagatc ttactcagag atttgaagaa aagctgcagg     1680

aactagaaag tgtttccagg gatcccagca atgagaatcc taaacttgaa gacctctgct     1740

tcatcttaca agaagagtac cacttaaacc cagagacaat aacaattctc tttgtgaaaa     1800

ccagagcact tgtggacgct ttaaaaaatt ggattgaagg aaatcctaaa ctcagttttc     1860

taaaacctgg catattgact ggacgtggca aaacaaatca gaacacagga atgaccctcc     1920

cggcacagaa gtgtatattg gatgcattca aagccagtgg agatcacaat attctgattg     1980

ccacctcagt tgctgatgaa ggcattgaca ttgcacagtg caatcttgtc atcctttatg     2040

agtatgtggg caatgtcatc aaaatgatcc aaaccagagg cagaggaaga gcaagaggta     2100

gcaagtgctt ccttctgact agtaatgctg gtgtaattga aaaagaacaa ataaacatgt     2160

acaaagaaaa aatgatgaat gactctattt tacgccttca gacatgggac gaagcagtat     2220

ttagggaaaa gattctgcat atacagactc atgaaaaatt catcagagat agtcaagaaa     2280

aaccaaaacc tgtacctgat aaggaaaata aaaaactgct ctgcagaaag tgcaaagcct     2340

tggcatgtta cacagctgac gtaagagtga tagaggaatg ccattacact gtgcttggag     2400

atgcttttaa ggaatgcttt gtgagtagac cacatcccaa gccaaagcag ttttcaagtt     2460

ttgaaaaaag agcaaagata ttctgtgccc gacagaactg cagccatgac tggggaatcc     2520

atgtgaagta caagacattt gagattccag ttataaaaat tgaaagtttt gtggtggagg     2580

atattgcaac tggagttcag acactgtact cgaagtggaa ggactttcat tttgagaaga     2640

taccatttga tccagcagaa atgtccaaat gatatcaggt cctcaatctt cagctacagg     2700

gaatgagtaa ctttgagtgg agaagaaaca aacatagtgg gtataatcat ggatcgcttg     2760

tacccctgtg aaaatatatt ttttaaaaat atctttagca gtttgtacta tattatatat     2820

gcaaagcaca aatgagtgaa tcacagcact gagtattttg taggccaaca gagctcatag     2880

tacttgggaa aaattaaaaa gcctcatttc tagccttctt tttagagtca actgccaaca     2940

aacacacagt aatcactctg tacacactgg gatagatgaa tgaatggaat gttgggaatt     3000

tttatctccc tttgtctcct taacctactg taaactggct tttgccctta acaatctact     3060

gaaattgttc ttttgaaggt taccagtgac tctggttgcc aaatccactg ggcacttctt     3120

aaccttctat ttgacctctg cgcatttggc cctgttgagc actcttcttg aagctctccc     3180

tgggcttctc tctcttctag ttctattcta gtcttttttt attgagtcct cctctttgct     3240

gatcccttcc aagggttcaa tatatataca tgtatatact gtacatatgt atatgtaact     3300

aatatacata catacaggta tgtatatgta atggttatat gtactcatgt tcctggtgta     3360

gcaacgtgtg gtatggctac acagagaaca tgagaacata aagccatttt tatgcttact     3420

actaaaagct gtccactgta gagttgctgt atgtagcaat gtgtatccac tctacagtgg     3480

tcagctttta gtagagagca taaaaatgat aaaatacttc ttgaaaactt agtttactat     3540

acatcttgcc ctattaatat gttctcttaa cgtgtgccat tgttctcttt gaccattttc     3600

ctataatgat gttgatgttc aacacctgga ctgaatgtct gttctcagat cccttggatg     3660

ttacagatga ggcagtctga ctgtcctttc tacttgaaag attagaatat gtatccaaat     3720

ggcattcacg tgtcacttag caaggtttgc tgatgcttca aagagcttag tttgcggttt     3780

cctggacgtg gaaacaagta tctgagttcc ctggagatca acgggatgag gtgttacagc     3840

tgcctccctc ttcatgcaat ctggtgagca gtggtgcagg cggggagcca gagaaacttg     3900

ccagttatat aacttctctt tggcttttct tcatctgtaa aacaaggata atactgaact     3960

gtaagggtta gtggagagtt tttaattaaa agaatgtgtg aaaagtacat gacacagtag     4020

ttgcttgata atagttacta gtagtagtat tcttactaag acccaataca aatggattat     4080

ttaaaccaa                                                             4089


<210> 2094
<211> 4621
<212> DNA
<213> Homo sapiens

<400> 2094
tagttattaa agttcctatg cagctccgcc tcgcgtccgg cctcatttcc tcggaaaatc       60

cctgctttcc ccgctcgcca cgccctcctc ctacccggct ttaaagctag tgaggcacag      120

cctgcgggga acgtagctag ctgcaagcag aggccggcat gaccaccgag cagcgacgca      180

gcctgcaagc cttccaggat tatatccgga agaccctgga ccctacctac atcctgagct      240

acatggcccc ctggtttagg gagggttatt ctggacttta tgaagccatt gaaagttggg      300

atttcaaaaa aattgaaaag ttggaggagt atagattact tttaaaacgt ttacaaccag      360

aatttaaaac cagaattatc ccaaccgata tcatttctga tctgtctgaa tgtttaatta      420

atcaggaatg tgaagaaatt ctacagattt gctctactaa ggggatgatg gcaggtgcag      480

agaaattggt ggaatgcctt ctcagatcag acaaggaaaa ctggcccaaa actttgaaac      540

ttgctttgga gaaagaaagg aacaagttca gtgaactgtg gattgtagag aaaggtataa      600

aagatgttga aacagaagat cttgaggata agatggaaac ttctgacata cagattttct      660

accaagaaga tccagaatgc cagaatctta gtgagaattc atgtccacct tcagaagtgt      720

ctgatacaaa cttgtacagc ccatttaaac caagaaatta ccaattagag cttgctttgc      780

ctgctatgaa aggaaaaaac acaataatat gtgctcctac aggttgtgga aaaacctttg      840

tttcactgct tatatgtgaa catcatctta aaaaattccc acaaggacaa aaggggaaag      900

ttgtcttttt tgcgaatcag atcccagtgt atgaacagca gaaatctgta ttctcaaaat      960

actttgaaag acatgggtat agagttacag gcatttctgg agcaacagct gagaatgtcc     1020

cagtggaaca gattgttgag aacaatgaca tcatcatttt aactccacag attcttgtga     1080

acaaccttaa aaagggaacg attccatcac tatccatctt tactttgatg atatttgatg     1140

aatgccacaa cactagtaaa caacacccgt acaatatgat catgtttaat tatctagatc     1200

agaaacttgg aggatcttca ggcccactgc cccaggtcat tgggctgact gcctcggttg     1260

gtgttgggga tgccaaaaac acagatgaag ccttggatta tatctgcaag ctgtgtgctt     1320

ctcttgatgc gtcagtgata gcaacagtca aacacaatct ggaggaactg gagcaagttg     1380

tttataagcc ccagaagttt ttcaggaaag tggaatcacg gattagcgac aaatttaaat     1440

acatcatagc tcagctgatg agggacacag agagtctggc aaagagaatc tgcaaagacc     1500

tcgaaaactt atctcaaatt caaaataggg aatttggaac acagaaatat gaacaatgga     1560

ttgttacagt tcagaaagca tgcatggtgt tccagatgcc agacaaagat gaagagagca     1620

ggatttgtaa agccctgttt ttatacactt cacatttgcg gaaatataat gatgccctca     1680

ttatcagtga gcatgcacga atgaaagatg ctctggatta cttgaaagac ttcttcagca     1740

atgtccgagc agcaggattc gatgagattg agcaagatct tactcagaga tttgaagaaa     1800

agctgcagga actagaaagt gtttccaggg atcccagcaa tgagaatcct aaacttgaag     1860

acctctgctt catcttacaa gaagagtacc acttaaaccc agagacaata acaattctct     1920

ttgtgaaaac cagagcactt gtggacgctt taaaaaattg gattgaagga aatcctaaac     1980

tcagttttct aaaacctggc atattgactg gacgtggcaa aacaaatcag aacacaggaa     2040

tgaccctccc ggcacagaag tgtatattgg atgcattcaa agccagtgga gatcacaata     2100

ttctgattgc cacctcagtt gctgatgaag gcattgacat tgcacagtgc aatcttgtca     2160

tcctttatga gtatgtgggc aatgtcatca aaatgatcca aaccagaggc agaggaagag     2220

caagaggtag caagtgcttc cttctgacta gtaatgctgg tgtaattgaa aaagaacaaa     2280

taaacatgta caaagaaaaa atgatgaatg actctatttt acgccttcag acatgggacg     2340

aagcagtatt tagggaaaag attctgcata tacagactca tgaaaaattc atcagagata     2400

gtcaagaaaa accaaaacct gtacctgata aggaaaataa aaaactgctc tgcagaaagt     2460

gcaaagcctt ggcatgttac acagctgacg taagagtgat agaggaatgc cattacactg     2520

tgcttggaga tgcttttaag gaatgctttg tgagtagacc acatcccaag ccaaagcagt     2580

tttcaagttt tgaaaaaaga gcaaagatat tctgtgcccg acagaactgc agccatgact     2640

ggggaatcca tgtgaagtac aagacatttg agattccagt tataaaaatt gaaagttttg     2700

tggtggagga tattgcaact ggagttcaga cactgtactc gaagtggaag gactttcatt     2760

ttgagaagat accatttgat ccagcagaaa tgtccaaatg atatcaggtc ctcaatcttc     2820

agctacaggg aatgagtaac tttgagtgga gaagaaacaa acatagtggg tataatcatg     2880

gatcgcttgt acccctgtga aaatatattt tttaaaaata tctttagcag tttgtactat     2940

attatatatg caaagcacaa atgagtgaat cacagcactg agtattttgt aggccaacag     3000

agctcatagt acttgggaaa aattaaaaag cctcatttct agccttcttt ttagagtcaa     3060

ctgccaacaa acacacagta atcactctgt acacactggg atagatgaat gaatggaatg     3120

ttgggaattt ttatctccct ttgtctcctt aacctactgt aaactggctt ttgcccttaa     3180

caatctactg aaattgttct tttgaaggtt accagtgact ctggttgcca aatccactgg     3240

gcacttctta accttctatt tgacctctgc gcatttggcc ctgttgagca ctcttcttga     3300

agctctccct gggcttctct ctcttctagt tctattctag tcttttttta ttgagtcctc     3360

ctctttgctg atcccttcca agggttcaat atatatacat gtatatactg tacatatgta     3420

tatgtaacta atatacatac atacaggtat gtatatgtaa tggttatatg tactcatgtt     3480

cctggtgtag caacgtgtgg tatggctaca cagagaacat gagaacataa agccattttt     3540

atgcttacta ctaaaagctg tccactgtag agttgctgta tgtagcaatg tgtatccact     3600

ctacagtggt cagcttttag tagagagcat aaaaatgata aaatacttct tgaaaactta     3660

gtttactata catcttgccc tattaatatg ttctcttaac gtgtgccatt gttctctttg     3720

accattttcc tataatgatg ttgatgttca acacctggac tgaatgtctg ttctcagatc     3780

ccttggatgt tacagatgag gcagtctgac tgtcctttct acttgaaaga ttagaatatg     3840

tatccaaatg gcattcacgt gtcacttagc aaggtttgct gatgcttcaa agagcttagt     3900

ttgcggtttc ctggacgtgg aaacaagtat ctgagttccc tggagatcaa cgggatgagg     3960

tgttacagct gcctccctct tcatgcaatc tggtgagcag tggtgcaggc ggggagccag     4020

agaaacttgc cagttatata acttctcttt ggcttttctt catctgtaaa acaaggataa     4080

tactgaactg taagggttag tggagagttt ttaattaaaa gaatgtgtga aaagtacatg     4140

acacagtagt tgcttgataa tagttactag tagtagtatt cttactaaga cccaatacaa     4200

atggattatt taaaccaagt ttatgagttg gttttttttc attttctatt tgtattttat     4260

taagagtgtc ttttcttatg tgattttttt taattgctat ttgatatggt ttggctatat     4320

gtccccaccc aaatctcatc ttgaattata atccccatgt gtcaagggag ggacctgacg     4380

ggaggtgatt ggatcacggg ggcagttgtc cccatgctgt tcttgggata gtgagttagt     4440

tctcatgaga tctgatggtt ttataagtgt ttgacaattc ctcctttaca cacactctct     4500

ctctcatctg ctgccatgta agacttgcct gcttcccctt ctgccatgat tgtaagtttc     4560

ctgaggcctc ctcagccatg tggaactgtg aatctattaa gcctcttttc tttataaatg     4620

a                                                                     4621


<210> 2095
<211> 4353
<212> DNA
<213> Homo sapiens

<400> 2095
tagttattaa agttcctatg cagctccgcc tcgcgtccgg cctcatttcc tcggaaaatc       60

cctgctttcc ccgctcgcca cgccctcctc ctacccggct ttaaagctag tgaggcacag      120

cctgcgggga acgtagctag ctgcaagcag aggccggcat gaccaccgag cagcgacgca      180

gcctgcaagc cttccaggat tatatccgga agaccctgga ccctacctac atcctgagct      240

acatggcccc ctggtttagg gaggaagagg tgcagtatat tcaggctgag aaaaacaaca      300

agggcccaat ggaggctgcc acactttttc tcaagttcct gttggagctc caggaggaag      360

gctggttccg tggctttttg gatgccctag accatgcagg ttattctgga ctttatgaag      420

ccattgaaag ttgggatttc aaaaaaattg aaaagttgga ggagtataga ttacttttaa      480

aacgtttaca accagaattt aaaaccagaa ttatcccaac cgatatcatt tctgatctgt      540

ctgaatgttt aattaatcag gaatgtgaag aaattctaca gatttgctct actaagggga      600

tgatggcagg tgcagagaaa ttggtggaat gccttctcag atcagacaag gaaaactggc      660

ccaaaacttt gaaacttgct ttggagaaag aaaggaacaa gttcagtgaa ctgtggattg      720

tagagaaagg tataaaagat gttgaaacag aagatcttga ggataagatg gaaacttctg      780

acatacagat tttctaccaa gaagatccag aatgccagaa tcttagtgag aattcatgtc      840

caccttcaga agtgtctgat acaaacttgt acagcccatt taaaccaaga aattaccaat      900

tagagcttgc tttgcctgct atgaaaggaa aaaacacaat aatatgtgct cctacaggtt      960

gtggaaaaac ctttgtttca ctgcttatat gtgaacatca tcttaaaaaa ttcccacaag     1020

gacaaaaggg gaaagttgtc ttttttgcga atcagatccc agtgtatgaa cagcagaaat     1080

ctgtattctc aaaatacttt gaaagacatg ggtatagagt tacaggcatt tctggagcaa     1140

cagctgagaa tgtcccagtg gaacagattg ttgagaacaa tgacatcatc attttaactc     1200

cacagattct tgtgaacaac cttaaaaagg gaacgattcc atcactatcc atctttactt     1260

tgatgatatt tgatgaatgc cacaacacta gtaaacaaca cccgtacaat atgatcatgt     1320

ttaattatct agatcagaaa cttggaggat cttcaggccc actgccccag gtcattgggc     1380

tgactgcctc ggttggtgtt ggggatgcca aaaacacaga tgaagccttg gattatatct     1440

gcaagctgtg tgcttctctt gatgcgtcag tgatagcaac agtcaaacac aatctggagg     1500

aactggagca agttgtttat aagccccaga agtttttcag gaaagtggaa tcacggatta     1560

gcgacaaatt taaatacatc atagctcagc tgatgaggga cacagagagt ctggcaaaga     1620

gaatctgcaa agacctcgaa aacttatctc aaattcaaaa tagggaattt ggaacacaga     1680

aatatgaaca atggattgtt acagttcaga aagcatgcat ggtgttccag atgccagaca     1740

aagatgaaga gagcaggatt tgtaaagccc tgtttttata cacttcacat ttgcggaaat     1800

ataatgatgc cctcattatc agtgagcatg cacgaatgaa agatgctctg gattacttga     1860

aagacttctt cagcaatgtc cgagcagcag gattcgatga gattgagcaa gatcttactc     1920

agagatttga agaaaagctg caggaactag aaagtgtttc cagggatccc agcaatgaga     1980

atcctaaact tgaagacctc tgcttcatct tacaagaaga gtaccactta aacccagaga     2040

caataacaat tctctttgtg aaaaccagag cacttgtgga cgctttaaaa aattggattg     2100

aaggaaatcc taaactcagt tttctaaaac ctggcatatt gactggacgt ggcaaaacaa     2160

atcagaacac aggaatgacc ctcccggcac agaagtgtat attggatgca ttcaaagcca     2220

gtggagatca caatattctg attgccacct cagttgctga tgaaggcatt gacattgcac     2280

agtgcaatct tgtcatcctt tatgagtatg tgggcaatgt catcaaaatg atccaaacca     2340

gaggcagagg aagagcaaga ggtagcaagt gcttccttct gactagtaat gctggtgtaa     2400

ttgaaaaaga acaaataaac atgtacaaag aaaaaatgat gaatgactct attttacgcc     2460

ttcagacatg ggacgaagca gtatttaggg aaaagattct gcatatacag actcatgaaa     2520

aattcatcag agatagtcaa gaaaaaccaa aacctgtacc tgataaggaa aataaaaaac     2580

tgctctgcag aaagtgcaaa gccttggcat gttacacagc tgacgtaaga gtgatagagg     2640

aatgccatta cactgtgctt ggagatgctt ttaaggaatg ctttgtgagt agaccacatc     2700

ccaagccaaa gcagttttca agttttgaaa aaagagcaaa gatattctgt gcccgacaga     2760

actgcagcca tgactgggga atccatgtga agtacaagac atttgagatt ccagttataa     2820

aaattgaaag ttttgtggtg gaggatattg caactggagt tcagacactg tactcgaagt     2880

ggaaggactt tcattttgag aagataccat ttgatccagc agaaatgtcc aaatgatatc     2940

aggtcctcaa tcttcagcta cagggaatga gtaactttga gtggagaaga aacaaacata     3000

gtgggtataa tcatggatcg cttgtacccc tgtgaaaata tattttttaa aaatatcttt     3060

agcagtttgt actatattat atatgcaaag cacaaatgag tgaatcacag cactgagtat     3120

tttgtaggcc aacagagctc atagtacttg ggaaaaatta aaaagcctca tttctagcct     3180

tctttttaga gtcaactgcc aacaaacaca cagtaatcac tctgtacaca ctgggataga     3240

tgaatgaatg gaatgttggg aatttttatc tccctttgtc tccttaacct actgtaaact     3300

ggcttttgcc cttaacaatc tactgaaatt gttcttttga aggttaccag tgactctggt     3360

tgccaaatcc actgggcact tcttaacctt ctatttgacc tctgcgcatt tggccctgtt     3420

gagcactctt cttgaagctc tccctgggct tctctctctt ctagttctat tctagtcttt     3480

ttttattgag tcctcctctt tgctgatccc ttccaagggt tcaatatata tacatgtata     3540

tactgtacat atgtatatgt aactaatata catacataca ggtatgtata tgtaatggtt     3600

atatgtactc atgttcctgg tgtagcaacg tgtggtatgg ctacacagag aacatgagaa     3660

cataaagcca tttttatgct tactactaaa agctgtccac tgtagagttg ctgtatgtag     3720

caatgtgtat ccactctaca gtggtcagct tttagtagag agcataaaaa tgataaaata     3780

cttcttgaaa acttagttta ctatacatct tgccctatta atatgttctc ttaacgtgtg     3840

ccattgttct ctttgaccat tttcctataa tgatgttgat gttcaacacc tggactgaat     3900

gtctgttctc agatcccttg gatgttacag atgaggcagt ctgactgtcc tttctacttg     3960

aaagattaga atatgtatcc aaatggcatt cacgtgtcac ttagcaaggt ttgctgatgc     4020

ttcaaagagc ttagtttgcg gtttcctgga cgtggaaaca agtatctgag ttccctggag     4080

atcaacggga tgaggtgtta cagctgcctc cctcttcatg caatctggtg agcagtggtg     4140

caggcgggga gccagagaaa cttgccagtt atataacttc tctttggctt ttcttcatct     4200

gtaaaacaag gataatactg aactgtaagg gttagtggag agtttttaat taaaagaatg     4260

tgtgaaaagt acatgacaca gtagttgctt gataatagtt actagtagta gtattcttac     4320

taagacccaa tacaaatgga ttatttaaac caa                                  4353


<210> 2096
<211> 2398
<212> DNA
<213> Homo sapiens

<400> 2096
agaatggcct cggacaccca ggcagtccct gacgtgtcgg ggaggagccg ggcgcggagg       60

tacgctgagt ggagctcggg gctgcgtagg ggagctgagc cgagcggctg ggcgggcctg      120

gccgggccgg cggaggggag acgtcggttg agcggcggcg aacatgcgct tttgacacat      180

tggaggcttt cttgatcatg gatggtgaag atataccaga tttttcaagt ttaaaggagg      240

aaactgctta ttggaaggaa ctttccttga agtataagca aagcttccag gaagctcggg      300

atgagctagt tgaattccag gaaggaagca gagaattaga agcagagttg gaggcacaat      360

tagtacaggc tgaacaaaga aatagagact tgcaggctga taaccaaaga ctgaaatatg      420

aagtggaggc attaaaggag aagctagagc atcaatatgc acagagctat aagcaggtct      480

cagtgttaga agatgattta agtcagactc gggccattaa ggagcagttg cataagtatg      540

tgagagagct ggagcaggcc aacgacgacc tggagcgagc caaaagggca acaatagttt      600

cactggaaga ctttgaacaa aggctaaacc aggccattga acgaaatgca tttttagaaa      660

gtgaacttga tgaaaaggaa tctttgttgg tctctgtaca gaggttaaag gatgaagcaa      720

gagatttaag gcaagaacta gcagttcggg aaagacaaca ggaagtaact agaaagtcgg      780

ctcctagctc tccaactcta gactgtgaaa agatggactc cgccgtccaa gcatcacttt      840

ctttgccagc tacccctgtt ggcaaaggaa cggagaacac ttttccttca ccgaaagcta      900

taccaaatgg ttttggtacc agtccactaa ctccctctgc taggatatca gcactaaaca      960

tcgtggggga tctcttacgg aaagtagggg ctttagaatc caaattagca gcttgcagga     1020

attttgcaaa ggaccaagca tcacgaaaat cctatatttc agggaatgtt aactgtgggg     1080

tgctgaatgg caatggcaca aagttctctc gatcagggca tacatctttc ttcgacaaag     1140

ggcaagaaaa agtcatattt cccacgttgt tcatggggca gtaaacggct ttgaccccgc     1200

tcctcctcct cctggtctgg gctcctcgcg tccatcgtca gcgccgggta tgctgcctct     1260

cagtgtgtga gtgcctagcc tccaggtggg ggctcctgcc ctcctccaac aacccaggac     1320

acccacgcct cacccctcgg tgcctgggcc cagccccgtg cccctccgtc tgcctccgca     1380

cggctggcag agggcaggct gcatgcagtg gcggctactg ggccctgccc agccccggaa     1440

ctctgcgcga tatcaatact ggctattttc tcttctcgcc gtagtgccgt tggtttcaca     1500

tgattgcact tttgtgggtc gcaaggtgat acatacgtgt attacttggt cactggatgc     1560

agaagtaccc attcatcaca cctgccccat agcccccact ctgctgtact gataggattt     1620

agttgtgttt taggacattg caaatcttct agaagttctc ccccaaatca ggtcaatgtg     1680

tgccctcctg agctcccacc caggcatctc cagtgctcat gatcatgtgt cccccaactc     1740

cacccctcac agtttgggcc tgtttctggc aaagagtcag gaaggttact gaattaggga     1800

acattttctg caccttctga ttttacttaa gcagctacca ttccatggac ttgcctccca     1860

gagcagcaca atgcccgtct gagccccacg tggcaggagc ctctgggacg gggcacacac     1920

aggcccagcc tctgtgctgt ctcctcctcc gtgcgcctca gactcggggt gagggaggcg     1980

ggcagcctct cgccagcctt cccgtccttc agttcaacga catctttgga gtgtttttgt     2040

tttctcttcc aagggccgtc ccgttgtgtt aggaagggtg agtggctggt tccagggtgg     2100

gccggtgcca gctccggggt ggactgaaca gcggcggctg tccctgtgca tcctttgatt     2160

actctcatgc tgcatttact gtttacattt gttttattgt acataggttt gtaaacatta     2220

ttgcctgaga tatttgtata taacttgggc tttgtagctt ttatttattc agaacgcata     2280

cggcatgtta atgactctga tggtgtcctc ctctgggcag ctgtatagga tcatcatgtg     2340

gttacaaaaa atacttccct caaaaaaatt cttttaatgt ggaaacaata aatttcac       2398


<210> 2097
<211> 3675
<212> DNA
<213> Homo sapiens

<400> 2097
gctgcgaggg ttgccgaagg cgcacggatc tgggcgctga aaaagccagg atttggcaat       60

ggctttgctg tgtggccttg ggcaagtcac tctgcgtatc tgggtttcac ttccttccca      120

atccgaaaac gggattgggt tccttgcagc ccgggcattc ctgaggagcg gcggcatgga      180

ggctctcacc actcagctgg ggccggggcg cgagggcagt tcctcgccca actccaagca      240

ggagctgcag ccgtactcgg gctccagcgc tctcaaaccc aaccaggtgg gcgagacgtc      300

gctgtacggg gtgcccattg tgtcgctggt catcgacggc caggagcgcc tatgcctggc      360

gcagatctcc aacaccctcc tcaagaacta cagctataat gagatccaca accgccgcgt      420

ggccctgggc atcacgtgcg tgcagtgcac gccggtacag ctggagattc tgcgtcgggc      480

cggggccatg cccatctcgt cgcgccgctg cggcatgatc actaagcgag aggccgaacg      540

cctgtgcaag tcgttcctgg gcgagcacaa accacccaag ctgcccgaga acttcgcctt      600

cgatgtggtg cacgagtgcg cgtggggctc gcgtggtagc ttcatccctg cgcgttacaa      660

cagctctcgt gccaagtgca tcaagtgcgg ctactgcagc atgtacttct cgcccaacaa      720

gttcatcttc cactcgcacc gaacacccga cgccaagtac acgcagcccg atgccgccaa      780

cttcaactcc tggcgtcgtc acctcaaact cagtgacaag tcggccacag acgaactgag      840

ccatgcttgg gaggacgtca aggccatgtt taatggcggc acgcgcaagc ggaccttctc      900

cctacaagga ggcggcggag gcggtgccaa tggcgggtcg ggtgggcagg ggaagggtgg      960

tgctggcggc ggtggcggcg gtggcccagg gtgcggtgca gagatggccc caggcccgcc     1020

gccccacaaa agcctgcgct gtggcgaaga tgaggctgcc gggcctccgg ggccacctcc     1080

accccacccg cagcgcggac ttggcctggc gactggagct agtggcccgg cgggcccagg     1140

agggcccggt ggcggcgccg gcgtacgaag ctacccggtg atcccggtgc ccagcaaagg     1200

ctttgggctc ctgcaaaagc tgcccccacc acttttcccc catccttacg gcttccctac     1260

ggccttcggc ctatgcccca aaaaggacga cccggtttta ggcgcgggcg agccaaaggg     1320

cggtcctggc actgggagcg gcggcggcgg cgcggggaca ggcgggggtg cggggggccc     1380

gggagccagc cacttgcccc cgggggcagg ggcgggcccg ggcggcggcg ccatgttctg     1440

ggggcatcaa ccctccgggg cagccaagga cgcagcggca gtggctgcag cggccgccgc     1500

cgccactgtg tacccgacgt ttcccatgtt ctggccagca gcaggcagcc tcccggtacc     1560

gtcctacccc gctgctcaga gccaagccaa ggccgtggcg gcagccgtgg cggcggcagc     1620

ggcggcggca gcggcagctg ctggcagcgg tgccccagag cccctggacg gtgccgagcc     1680

agccaaagag agtggcctcg gcgcggagga gcgctgcccg agcgctctgt cccgcgggcc     1740

cctggacgaa gacggcacgg acgaggcgct gccaccgccc ctggccccgt tgcccccgcc     1800

gcccccgccg cccgcacgca aaggctccta cgtgtcggcc ttccggccgg tggtcaagga     1860

caccgagagc atcgctaagc tctacgggag cgcccgggag gcgtacggcg cggggcctgc     1920

tcgggggccg ggacccggcg ctgggagcgg cggctacgtg agcccggact ttctgagcga     1980

gggcagctcc agctacaatt ccgcctcgcc cgacgtggac accgcggacg agcccgaggt     2040

ggacgtggaa tccaaccgct tccccgacga cgaggacgcc caagaggaga ccgagcccag     2100

cgcacccagc gcagggggcg gcccagacgg tgaacagccc actggacccc cttccgccac     2160

ctcctctggc gcggacggtc ccgcaaactc tcccgacggc ggcagccccc gcccccggcg     2220

ccgcctcggg ccacccccag ctggccggcc cgcatttggg gacttggcag ccgaagactt     2280

ggtgcggaga cctgagagga gcccgccaag cggcggcggc ggctacgagc tgcgagagcc     2340

ttgcgggccc ctaggaggcc ccgcgccggc caaggtgttc gcgcccgaga gggatgagca     2400

cgtgaagagc gcggcggtgg cgctggggcc cgcggcctcc tacgtctgca cccccgaggc     2460

ccacgagcca gataaggaag acaatcactc gcccgccgat gatttggaaa cgaggaaatc     2520

ctatccagac caaaggagta tctcccagcc aagtcctgca aatacagaca gaggcgaaga     2580

tgggcttacc ttggatgtca caggaactca tttggtggag aaagatatcg agaacctggc     2640

cagagaggaa ttgcaaaaac tgctcctgga acaaatggag ctccgcaaga agctggaacg     2700

ggaatttcag agtctcaaag ataattttca ggatcaaatg aagagggaat tggcttatcg     2760

agaagaaatg gtgcaacagc tgcaaattgt cagagatacc ctgtgtaacg aactcgacca     2820

ggagcggaag gcgcgctatg ccatccagca gaaattgaaa gaagcccacg acgccctgca     2880

ccatttctcc tgcaagatgc tgacgccccg ccactgcact ggcaactgct ccttcaagcc     2940

accgctgttg ccctagggcc ggcctggccg cacccctgcg ccctcaagcc atgctgctcc     3000

ttgtaaatac ccgctgctgc ggtggccctg agcgaggaac aagccattcg gacccgaccg     3060

atgtaaatac agccgcccgt ccgcccgcct tcctcccggg ctccccggcc ttgcccgccc     3120

cctcccgggc gtccctgtcc agggccccgg cttggtttcc aagtgtaaat accgcctcgc     3180

gcctcaaatc cccctacccc gtgtgaactc tagggcatcg gacctcaagg ggttaactgg     3240

acagacgggg ggcgggaggg gagagcgccc cctcccattg tatagccttg aacccgattg     3300

tgaatacaat gtagcaactt cgctggcgcc tgccccgcac tccccgtccc gtccacttct     3360

gaaactcctg ttcctaatga caaagtggct atgtgcaatg gatataaatg tactgtgagt     3420

ctctcggttc agtattaggt tcactttaat ttatttatgc tgtaagttat ttttgcttcc     3480

ttctcctgga cccacttcca gtcccgtttt gcattcccct ttggattttg ctttggctat     3540

tttttgttgt aacctcttga tgtaacagca ctttaaaagg gcgacaactg actcacgaga     3600

tggcaaccac ctggagcctg tttggggaga ccaccctgta cccgtgactt tcgtttttaa     3660

taataataat aataa                                                      3675


<210> 2098
<211> 2160
<212> DNA
<213> Homo sapiens

<400> 2098
atcccgcccc cgttgccggg atacgccgcg gcgcacggca gttagtgggt aggcctgaga       60

gccgaggaaa actgagcgtg ggcctcagaa agaagttaag gcacccgcga gccgggcaac      120

tgccctcctt ccgcgccggc ggagcgatta aagtgaagaa acaatggcca gcaatcacaa      180

atcttcagca gctcgccctg tttcaagagg tggagttggg ttaacaggaa ggcctccttc      240

tgggatacga cccctatcag gaaatattcg agtggcaact gcaatgccac ctgggacagc      300

aagaccaggt tctcgtggtt gtcccatagg gactggtgga gttctgtctt ctcaaatcaa      360

agttgcccat cgccctgtaa cacaacaagg tttgactgga atgaaaactg ggacgaaagg      420

tccccagagg caaattttag acaaatctta ctatcttggg cttcttagaa gtaaaataag      480

tgaacttaca actgaagtta ataaacttca gaagggaata gaaatgtaca atcaagagaa      540

ttcagtatat ttgtcatatg aaaagagggc tgagacttta gctgttgaga taaaagagct      600

tcaaggacaa ctagcagact acaacatgtt ggtagataaa cttaatacca acactgaaat      660

ggaagaagta atgaatgatt acaatatgct taaagctcaa aatgatcgag aaacacaaag      720

tttggatgtc atatttactg aaagacaagc gaaagaaaaa caaatcagaa gtgtcgaaga      780

agaaattgaa caggaaaaac aagcaacaga tgacattatc aaaaatatgt cttttgaaaa      840

ccaagtcaag tacctagaga tgaaaaccac aaatgagaaa ctgttacagg aattagatac      900

acttcaacaa caattggatt cacagaacat gaaaaaagag agcctggaag cagaaatagc      960

tcactcccag gtgaaacagg aggcggtatt gctgcatgaa aaactttatg agttggagtc     1020

ccatcgagat caaatgattg cagaagacaa aagcatagga tctccaatgg aagagagaga     1080

gaaattactt aagcagatta aagatgataa tcaggaaata gccagcatgg aaagacagtt     1140

aacagataca aaagaaaaga taaatcagtt tattgaagaa attagacaac ttgacatgga     1200

tttagaggaa caccaaggtg aaatgaacca gaaatacaag gagctaaaga aaagggagga     1260

acatatggac acttttattg agacttttga ggaaacaaag aatcaggaac tgaaacgaaa     1320

ggcacagata gaagccaaca ttgttgcact cttggagcac tgcagtcgaa atataaatcg     1380

tatagaacag atatcctcta tcaccaatca agagctaaag atgatgcagg atgacctcaa     1440

ttttaaatct actgaagtgc agaaatcaca aagtacagct cagaatttga cttcagacat     1500

tcaacgtctg cagttggatc tgcagaaaat ggagcttcta gaaagtaaga tgactgaaga     1560

acagcattct ctaaaaagca aaattaagca aatgacaact gatctggaga tatataatga     1620

tttgccagct ttaaaatcat caggtgaaga aaagataaag aaattacatc aggagagaat     1680

gatattatca acccacagaa atgcctttaa gaaaataatg gagaagcaaa acatagagta     1740

tgaggcacta aaaacacaat tgcaagaaaa tgagacacat tctcagctta caaatttgga     1800

gagaaagtgg caacaccttg agcaaaataa ttttgcgatg aaagaattca tagcaaccaa     1860

gagtcaagag agtgattacc agccaattaa gaaaaatgtg accaagcaga ttgcagagta     1920

caataaaacc atcgtggatg ctttacatag caccagcgga aactgagttt aagtccactg     1980

aaagtctcta aggaagtatc ctcttgctgc taaacttggt acaagttgac taccaaaaaa     2040

aaaaaaagct tacttttgga gtttacctaa aatttctgaa tgttataatt tttgtggcct     2100

cttttaagaa tgatatttta aaatagtaaa tagttcaata aatggtttgc atattaaaaa     2160


<210> 2099
<211> 1389
<212> DNA
<213> Homo sapiens

<400> 2099
aaacagtgct acccacagag tgaacaagag agagtcattt gggaaacaaa aggagaattt       60

tacagagaga gagggatagc taaaactacg tgagcctggc gagggtgcag agcagaaagt      120

agagactgtc cgaagactgc tatctgggac gagacaagtt gttaaaggga caggagagaa      180

agcagagcta tttcaagagt gagccacaga agggaatcca gaggccatct aagcgaggaa      240

gggtctacag gcagtgagtg aaggccagga gcagggccca ggccaggcac gaccaccgag      300

gggatgaact tcacagtggg tttcaagccg ctgctagggg atgcacacag catggacaac      360

ctggagaagc agctcatctg ccccatctgc ctggagatgt tctccaaacc agtggtgatc      420

ctgccctgcc aacacaacct gtgccgcaaa tgtgccaacg acgtcttcca ggcctcgaat      480

cctctatggc agtcccgggg ctccaccact gtgtcttcag gaggccgttt ccgctgccca      540

tcgtgcaggc atgaggttgt cctggacaga cacggtgtct acggcctgca gcgaaacctg      600

ctagtggaga acattatcga catttacaag caggagtcat ccaggccgct gcactccaag      660

gctgagcagc acctcatgtg cgaggagcat gaagaagaga agatcaatat ttactgcctg      720

agctgtgagg tgcccacctg ctctctctgc aaggtcttcg gtgcccacaa ttacaaacgc      780

cagaagagtg agctcagcga tggcatcgcg atgctggtgg caggcaatga ccgcgtgcaa      840

gcagtgatca cacagatgga ggaggtgtgc cagactatcg aggacaatag ccggaggcag      900

aagcagttgt taaaccagag gtttgagagc ctgtgcgcag tgctggagga gcgcaagggt      960

gagctgctgc aggcgctggc ccgggagcaa gaggagaagc tgcagcgcgt ccgcggcctc     1020

atccgtcagt atggcgacca cctggaggcc tcctctaagc tggtggagtc tgccatccag     1080

tccatggaag agccacaaat ggcgctgtat ctccagcagg ccaaggagct gatcaataag     1140

gtcggggcca tgtcgaaggt ggagctggca gggcggccgg agccaggcta tgagagcatg     1200

gagcaattca ccgtaagggt ggagcacgtg gccgaaatgc tgcggaccat cgacttccag     1260

ccaggcgctt ccggggagga agaggaggtg gccccagacg gagaggaggg cagcgcgggg     1320

ccggaggaag agcggccgga tgggccgttg ggcccttata gtgcctacgt tagtctgtgt     1380

ggagcccct                                                             1389


<210> 2100
<211> 1967
<212> DNA
<213> Homo sapiens

<400> 2100
acagtaaaat taatctgctc tctggggagt aagggacaaa cagtgctacc cacagagtga       60

acaagagaga gtcatttggg aaacaaaagg agaattttac agagagagag ggatagctaa      120

aactacgtga gcctggcgag ggtgcagagc agaaagtaga gactgtccga agactgctat      180

ctgggacgag acaagttgtt aaagggacag gagagaaagc agagctattt caagagtgag      240

ccacagaagg gaatccagag gccatctaag cgaggaaggg tctacaggca gtgagtgaag      300

gccaggagca gggcccaggc caggcacgac caccgagggg atgaacttca cagtgggttt      360

caagccgctg ctaggggatg cacacagcat ggacaacctg gagaagcagc tcatctgccc      420

catctgcctg gagatgttct ccaaaccagt ggtgatcctg ccctgccaac acaacctgtg      480

ccgcaaatgt gccaacgacg tcttccaggc ctcgaatcct ctatggcagt cccggggctc      540

caccactgtg tcttcaggag gccgtttccg ctgcccatcg tgcaggcatg aggttgtcct      600

ggacagacac ggtgtctacg gcctgcagcg aaacctgcta gtggagaaca ttatcgacat      660

ttacaagcag gagtcatcca ggccgctgca ctccaaggct gagcagcacc tcatgtgcga      720

ggagcatgaa gaagagaaga tcaatattta ctgcctgagc tgtgaggtgc ccacctgctc      780

tctctgcaag gtcttcggtg cccacaagga ctgtgaggtg gccccactgc ccaccattta      840

caaacgccag aagagtgagc tcagcgatgg catcgcgatg ctggtggcag gcaatgaccg      900

cgtgcaagca gtgatcacac agatggagga ggtgtgccag actatcgagg acaatagccg      960

gaggcagaag cagttgttaa accagaggtt tgagagcctg tgcgcagtgc tggaggagcg     1020

caagggtgag ctgctgcagg cgctggcccg ggagcaagag gagaagctgc agcgcgtccg     1080

cggcctcatc cgtcagtatg gcgaccacct ggaggcctcc tctaagctgg tggagtctgc     1140

catccagtcc atggaagagc cacaaatggc gctgtatctc cagcaggcca aggagctgat     1200

caataaggtc ggggccatgt cgaaggtgga gctggcaggg cggccggagc caggctatga     1260

gagcatggag caattcaccg taagggtgga gcacgtggcc gaaatgctgc ggaccatcga     1320

cttccagcca ggcgcttccg gggaggaaga ggaggtggcc ccagacggag aggagggcag     1380

cgcggggccg gaggaagagc ggccggatgg gccttaaggc ctgcgccgac ccgaccctgc     1440

tcgagagccc gcgctagagt cggggaggat ctgcgcagag accgcagcat cacccaaatc     1500

ggcgccggcc ccgggaggat ctcaataaag aactcgagcg tcccagaccc gtatctcctt     1560

tcgctgccca accccgcagc ctgggcttcg aaggcgaccc gcccaccatc ctgcccttcc     1620

cagaacctga gaccgtctgg ggggcggaag ccaaatgaac ccctattggg cacctctgtg     1680

atgccaggag cgaactggtg agcccagcgc cctgggaaga gggccgaggg cggggcggtg     1740

gtgccgggac ctctgaggtc ctggggattt ggggaccctt ggggtccaca tgcacctggc     1800

tgacctggct gaaagccgct gtctcggagc cccccacagc attttgttcc cctcccgctg     1860

gcccgggggc cccaccttcc cacgggttcc cacgctgctg tgactgccct gcctctacga     1920

caaaagccaa cgggtcttca gtacttttat taaaaaatag tcacgca                   1967


<210> 2101
<211> 1098
<212> DNA
<213> Homo sapiens

<400> 2101
cactcactca cacactcact cactcacaca cctcccccag ctcaccgcct ccccactcca       60

gcatggccgc ctccaccatg tccatctgct ccagcgcctg cactgactct tggcgggtag      120

tcgactgccc agagagctgc tgcgagccct gctgctgtgc cccagccccc agcttgaccc      180

tggtctgcac cccagtgagc tgtgtgtcca gcccctgctg ccagacggcc tgtgagccca      240

gcgcctgcca atcaggctac accagctcct gcacaacccc atgctaccag cagtctagct      300

gccagccgga ttgctgcacc tcctccccct gccagcaggc ctgctgtgtg cctgtctgct      360

gtgtgcccgt ctgctgcgtg cccgtctgta acaagcctgt gtgcttcgtg cctacctgct      420

ccgagtcttc cccttcatgc tgccagcagt ctagctgcca gccaacttgc tgcacctcct      480

ccccatgcca gcaggcctgc tgtgtgcctg tctgctctaa gtccgtctgc tatgtgcctg      540

tgtgctctgg ggcttccact tcatgctgcc agcagtctag ctgccagcct gcttgctgca      600

ccgcctcctg ctgcagaccc tcctcctccg tgtccctcct ctgccaccct gtgtgcaagt      660

ccacctgctg cgtgcccgtc ccctcctgcg gtgcctctgc ctcctcctgc cagcccagct      720

gctgccgcac ggcctcctgt gtttccctcc tctgccgccc cgtgtgctcc cgccctgcct      780

gctacagcct ctgctctggc cagaagtcca gctgctgaca gccctggatg tgatccggag      840

tcccttccca ccaggggctg acctcccagc tgccccagca agctctgccc tctctggctt      900

tgacaccctc agaaggtggg gcaggctctt tgtcttgggg accaggatgc tcccccagtc      960

cttcccagat gatggctgcc tgtgggaccc cagctactcc cccagaccca agttctgcag     1020

aactaacccc cagcaggcct ggttccaccc tgggcagcac cccctctagt tctaataaag     1080

ccgcctctgt ctcacacc                                                   1098


<210> 2102
<211> 1595
<212> DNA
<213> Homo sapiens

<400> 2102
catctcctcc agttcaatcc ccagcatggc cgcgtccact atgtctgtct gctccagcga       60

cctgagctac ggcagccgcg tctgccttcc tggttcctgt gactcttgct ccgactcctg      120

gcaggtggac gactgcccag agagctgctg cgagcccccc tgctgcgccc ccagctgctg      180

cgccccggcc ccctgcctga gcctggtctg caccccagtg agccgtgtgt ccagcccctg      240

ctgcccagtg acctgtgagc ccagcccctg ccaatcaggc tgcaccagct cctgcacgcc      300

ctcgtgctgc cagcagtcta gctgccagct ggcttgctgt gcctcctccc cctgccagca      360

ggcctgctgc atgcccgtct gctgcaagac tgtctgctgc aagcctgtgt actgtgtgcc      420

tgtctgcagt ggggattctt catgctgcca gcagtctagc tgccagtcag cttgctgcac      480

ctcctccccc tgccagcagg cctgctgtgt gcccatctgc tgcaagcctg tctgctctgg      540

gatttcctct tcgtgctgcc agcagtctag ctgtgtgagc tgtgtgtcca gcccctgctg      600

ccaggcggtc tgtgagccca gcccctgcca atcaggctgc atcagctcct gcacgccctc      660

gtgctgccag cagtctagct gccagccggc ttgctgcacc tcctccccct gccagcaggc      720

ctgctgtgtg cctgtctgct gcaagcccgt ctgctgtgtg cccacctgct ctgatgattc      780

cggttcatgc tgccagccag cttgctgcac ctcctcccaa agccagcagg gctgctgcgt      840

gcccgtctgc tgtaagcctg tgtgctgtgt gcctgtctgc tctggggctt ccagttcatg      900

ctgccagcag tctagctgcc agccggcttg ctgcaccacc tcctgctgca gaccctcctc      960

ctccgtgtcc ctcctctgcc gccctgtgtg caggcccacc tgctgcgtgc ccgtcccctc     1020

ctgctgcgcc cccacctcct cctgccaggc cagctgctgc cgcccagcct cctgtgtgtc     1080

tctcctttgc cgccccgcat gctcccgccc agcctgctgt ggccccacct caacccagaa     1140

gtccagctgc tgagtgatct ccttaagatc atccaaagcc tgagtgctca ctgccacctg     1200

cacccctgga ttctttaccc ttgacggctc tccacatccc gctcctaagc cctgcagtgg     1260

acatcagtgg tcagctggcc atccagtgtg cgcttctcct cctagaagca gctcagctgt     1320

ttctccaagt cttgactttc ccccaattac ccagccctgc ttccccagca acaggtgggc     1380

agtgacccca gcaaggccag cgggtgctcc caggccatag cccggtgtgg ggagaaacga     1440

gggtagacac gtaccaactg tgggtttctc gtcactgtcc cagctcagtg gcgagccctg     1500

ctcctcccct gctgtgggcc tgggcctctt tctctgtctt ccctgaccac gggagcaggt     1560

cagacccttc taataaactc ctttcctaaa aagta                                1595


<210> 2103
<211> 4401
<212> DNA
<213> Homo sapiens

<400> 2103
aaggccctgc gagattctgt gccccttgtc gggccgcttg tttggctgct gccgtcacct       60

catggcgacg cgggtagagg aggcagcgcg gggaagaggc ggcggcgccg aagaggcgac      120

tgaggccgga cggggcggac ggcgacgcag cccgcggcag aagtttgaaa ttggcacaat      180

ggaagaagct ggaatttgtg ggctaggggt gaaagcagat atgttgtgta actctcaatc      240

aaatgatatt cttcaacatc aaggctcaaa ttgtggtggc acaagtaaca agcattcatt      300

ggaagaggat gaaggcagtg actttataac agagaacagg aatttggtga gcccagcata      360

ctgcacgcaa gaatcaagag aggaaatccc tgggggagaa gctcgaacag atccccctga      420

tggtcagcaa gattcagagt gcaacaggaa caaagaaaaa actttaggaa aagaagtttt      480

attactgatg caagccctaa acaccctttc aaccccagag gagaagctgg cagctctctg      540

taagaaatat gctgatcttc tggaggagag caggagtgtt cagaagcaaa tgaagatcct      600

gcagaagaag caagcccaga ttgtgaaaga gaaagttcac ttgcagagtg aacatagcaa      660

ggctatcttg gcaagaagca agctagaatc tctttgcaga gaacttcagc gtcacaataa      720

gacgttaaag gaggaaaata tgcagcaggc acgagaggaa gaagaacgac gtaaagaagc      780

aactgcacat ttccagatta ccttaaatga aattcaagcc cagctggagc agcatgacat      840

ccacaacgcc aaactccgac aggaaaacat tgagctgggg gagaagctaa agaagctcat      900

cgaacagtac gcactgaggg aagagcacat tgataaggtg ttcaaacata aggaactgca      960

acagcagctc gtggatgcca aactgcagca aacgacacaa ctgataaaag aagctgatga     1020

aaaacatcag agagagagag agtttttatt aaaagaagcg acagaatcga ggcacaaata     1080

cgaacaaatg aaacagcaag aagtacaact aaaacagcag ctttctcttt atatggataa     1140

gtttgaagaa ttccagacta ccatggcaaa aagcaatgaa ctgtttacaa ccttcagaca     1200

ggaaatggaa aagatgacaa agaaaattaa aaaactggaa aaagaaacaa taatttggcg     1260

taccaaatgg gaaaacaata ataaagcact tctgcaaatg gctgaagaga aaacagtccg     1320

tgataaagag tacaaggccc ttcaaataaa actggaacgg ttagagaagc tgtgcagggc     1380

tcttcagaca gaaaggaatg agctcaatga gaaggtggaa gtcctgaaag agcaggtatc     1440

catcaaagcg gccatcaaag cggcgaacag ggatttagca acacctgtga tgcagccctg     1500

tactgccctg gattctcaca aggagctgaa cacttcctcg aaaagagccc tgggagcgca     1560

cctggaggct gagcccaaga gtcagagaag cgctgtgcaa aagcccccgt ccacaggctc     1620

tgctccggcc atcgagtcgg ttgactaaga tgaggtgtga tcactgtatt gagagatata     1680

ttttgtgtat aactttctct gttagtagtt aactattggt tttgtggtga aaattttctt     1740

actttttcta ccatatctgt attttcttag aactactgga cttatgtggt acaggaggct     1800

gcttagcagt tttgaatagt ttaatctata aattttcctc agctgtgttg cacatcagcc     1860

tcgttctccc tccactggaa tgcatgtgtt cattgccttg tcctttctct ccctgctcct     1920

tgcacattat catcctaatg aaaatttcac tgacagggcc gaccattaca agggaacttt     1980

gttctgacga tggttccttg atgtgaaaac aatattaatt taaacgtctt agcccccccc     2040

cccataatat tattcagaaa aacaaaatac caaggcgatt agttttgtct aataacccat     2100

ttaaatgcca agtaaaaata aaactcctag tgttgggtca gaagcatatt tgattgaaat     2160

tagctttttg aaaacattta tatctcggga caaattgaga tggccacatg cctagaatcc     2220

taagtttcgg cagaatatgt atataaagat gtcacttgtg gacaaaatag tacatagagg     2280

caaatcacta gacaaataag cttagtgttt acgtgactga acagtcatcc tgctttggtt     2340

tcaggtgtgg gatttggacc atgaggggct cccgtagagg atggcggttt gtgtttgatt     2400

ctgatttggg atttcagtac atattctcca cttcccatag aaggccactt attctttgaa     2460

aactggtgtt catgtttgcc gttcaatgaa gtcccttgtc aaagacaagg acggtcaatt     2520

cacgtgtcac tttcactagg cagaagtttc tccaatacct tctggctact tgaaagttac     2580

tacaaaaatt ccaccagcaa agtactccag gtttttcaaa agggaatttt cattatggat     2640

cagtaccaac cgaaattgat tttcatttcc aaaacaaaca ctggcaccaa catttttact     2700

ttgggaagac ttggcagagt gttagtcatg atctgttact tacgtgttca gtctgttttc     2760

tcaccccctt cttagttacc atctcttttt taagaagaaa aaagaaaagc cacagtatta     2820

tcaaggtctc tacacttgga ctgggggaaa atttgaaatt aagcacataa cttttgaatt     2880

agttctttgt ttcaatgttg aatgtggcgc agttatgcag atgattaatc aggctgcact     2940

gatggaagtt ttgactttgt ccctggtata atttgcattg aaatgcttta tgaaataaaa     3000

ggttctacta gaactgatgt tagcacattc cactgagcaa aactatcaga ctgacacttg     3060

ttaaattgct tactggactg aataaactct gttttgtcca gttaaaaggg ttttctcttt     3120

gttacaagtg ttatttgtaa agtcctgtca cattcatggt cgaaactggg ttgaaagaat     3180

tgaaaattgt ccaacagata gatagatagg aaaccgcctg gagtggagga gggttgtatc     3240

taagcctcca ctatcagtca tgttaattca aggggccaca gtggaggaaa ataaatccac     3300

aaagtagatt atctaattac catcaaaatg agtcagaagc aaaaaacacc accctccaac     3360

agcctcttag gagtacaccc tgttctgcta ctaaaatact agactcattt ccctggtggt     3420

gggggggaat gcaggtatag atcagaaata taatccacct taaaattagt actaatgatc     3480

acattatttc acaagaactc tgctggatgt acagctctta acattttatt aagccatttg     3540

tgtagcccac cacgtttctt tgtggtgctt gtcctgtgtg gaagattgta aatcttgggc     3600

ctgttgcata cttccaaggg ctttaaagca atgtgattaa cagtacttgg cctgctgctt     3660

ttggcttact ttgtattttt agctagatgc tattatagtg ttgaaaggat atggattctg     3720

tctgggatgc atttgttgtc ctttcagaac ccttcctccc attaccctgt gaataaaaac     3780

aaatgggacc ccctgagaag gacatcttcc tacagtgatc acctcaccag cccagtgttg     3840

tggctttgta gcgcaccccg tatctaccat attctagaac actgtaatgc tactaggctg     3900

gcccagaaaa ggtttaaatg ttgaattcac ttaaattgca attgttgcac catcatggaa     3960

tcgtgatgtg tattatttat attggcggtg gactccaagg tgtagagaaa acttgggtct     4020

tgggtaatat ggaccatttc atcctcagac ttgttaggag tacatttctt ggtcttgaga     4080

ccagtatttt tcagttatgt atgcaactgc ctttattaca cctggttatc acaattcaat     4140

tctcaggtgt tgcagaaaaa tctacctctt tcagactgta gatggaaata actgtgaaaa     4200

aaatgatgca gatatcttct agtttgtgct aaacacactg ctttattttt acagcccacg     4260

tctttcatga ggatacgaat tgttaagagg cagtctcgtt ttgcttttca aagacatttt     4320

gtagagattt ttcactaatg tgaatctgat tttatctact tgattctgta tagattaagt     4380

aaatatgtat gataaactta a                                               4401


<210> 2104
<211> 412
<212> DNA
<213> Homo sapiens

<400> 2104
agtatgcacc gcgatgcgcg cctcaccctg catctcccag cccgcagcca gctggcatcc       60

tagaccctct gccctgcgac caacagccgg gagcggacca gacaccagaa ctcccggaac      120

ggttgaagac ggttccgctc cctgtcccgc ctttcgcagc ccagcagttt cgccctgcgg      180

agaggagcct tgctgtttcc aaatctctcc tgctgaagag acattggagc tagggcggct      240

agtttcacct ggtaattgtg acaccctgtc tcctcgagct gcaggctttt atgcttgtca      300

tgttcgaagt ttgatacctt gcagatcaac aaagggccgg tggcctctca ctgcctccgc      360

ggcagggttg tcaagacatg cgcagtgcgg cccgtcccta gggctgggtt aa              412


<210> 2105
<211> 2605
<212> DNA
<213> Homo sapiens

<400> 2105
gtccactggg cttggagtca gtggcaataa ccaggggcaa taaccaggcg tgtcccaggg       60

gggagccccg ctctgcagcc ctgtgcgccg tagagagctg gacttaggct ggcagcatgg      120

ccgagttcag ggtcagggtg tccaccggag aagccttcgg ggctggcaca tgggacaaag      180

tgtctgtcag catcgtgggg acccggggag agagcccccc actgcccctg gacaatctcg      240

gcaaggagtt cactgcgggc gctgaggagg acttccaggt gacgctcccg gaggacgtag      300

gccgagtgct gctgctgcgc gtgcacaagg cgcccccagt gctgcccctg ctggggcccc      360

tggccccgga tgcctggttc tgccgctggt tccagctgac accgccgcgg ggcggccacc      420

tcctcttccc ctgctaccag tggctggagg gggcggggac cctggtgctg caggagggta      480

cagccaaggt gtcctgggca gaccaccacc ctgtgctcca gcaacagcgc caggaggagc      540

ttcaggcccg gcaggagatg taccagtgga aggcttacaa cccaggttgg cctcactgcc      600

tggatgaaaa gacagtggaa gacttggagc tcaatatcaa atactccaca gccaagaatg      660

ccaactttta tctacaggct ggctctgctt ttgcagagat gaaaatcaag gggttgctgg      720

accgcaaggg gctctggagg agtctgaatg agatgaaaag gatcttcaac ttccggagga      780

ccccagcagc tgagcacgca tttgagcact ggcaggagga cgccttcttc gcctcccagt      840

tcctgaatgg tctcaaccct gtcctgatcc gccgctgtca ctacctccca aagaacttcc      900

ccgtcactga tgccatggtg gcctcagtgt tgggtcctgg gaccagcttg caggctgagc      960

tagagaaggg ctccctgttc ttggtggatc acggcatcct ctctggcatc cagaccaatg     1020

tcattaatgg gaagcctcag ttctctgcgg ccccaatgac cctgctatac cagagcccag     1080

gctgcgggcc gctgctgcct ctcgccatcc agctcagcca gacccccggc ccaaacagcc     1140

ccatcttcct gcccactgat gacaagtggg actggttgct ggccaagacc tgggtgcgca     1200

atgccgagtt ctccttccat gaggccctca cgcacctgct gcactcacat ctgctgcctg     1260

aggtcttcac cctggctacc ctgcgtcagc tgccccactg ccaccctctc ttcaagtcca     1320

caggcatcgg cattgaaggc ttctctgagt tgatacagag gaacatgaag cagctgaact     1380

attctctcct gtgtctgcct gaggatatcc ggacccgagg agttgaagac atcccaggct     1440

actactaccg tgatgatggg atgcagatct ggggtgcagt ggaacgcttt gtctctgaaa     1500

tcatcggtat ctactaccca agtgatgagt ctgtccaaga tgacagagag ctccaggcct     1560

gggtcagaga gatcttctcc aagggcttcc taaaccagga gagctcaggt ataccctcct     1620

cactggagac ccgggaagcc ctggtgcagt atgtcaccat ggtgatattc acctgctccg     1680

ccaagcatgc ggctgtcagt gcagggcagt ttgactcctg tgcttggatg cccaacctgc     1740

cacccagcat gcagctgcca ccacccacct ccaaaggcct ggcaacatgc gagggcttca     1800

tagccaccct cccacctgtc aatgccacat gtgatgtcat ccttgctctc tggttgctga     1860

gcaaggagcc tggagaccaa aggcccctgg gcacctatcc ggatgagcac ttcacagagg     1920

aggcccctcg gcggagcatc gccaccttcc agagccgcct ggcccagatc tcgaggggca     1980

tccaggagcg gaaccagggc ctggtgctgc cctacaccta cctagaccct cccctcatcg     2040

agaacagcgt ctccatctaa atcccagggg aacacaggcc cagatgacat ccctttgacc     2100

acatcgctct aggataactg gcacccagag aaaaggactc ctcagaaaaa acaggccccc     2160

atgtgcctct cctgggacaa ccagactctg taactcaccc ccaccaccat acacacacac     2220

aaaaacagaa acaaaatcaa aacagagaaa gcagaaaatc taccaagaac agagtctcag     2280

gacagaacca ctgagtcttt tggaggctcc aagcctcaaa gtgcccgcag agcccacctt     2340

gagggttttg ctagttggtt ttgttttgcg ttttacagcc gtggggggaa gcacataatc     2400

ccgccccagg gcccactagc atccactgat tggaccttat ggtcacccaa ctcaaggaca     2460

gccaccaaga agtggctgcc aaagagactg ggcgcagtgg ctcatgccca taatcccagc     2520

actttgggag atggaggcgg gaaaatcatt tgaggtcaga agttcaaggc cagcctggac     2580

gacatagcga gactccacct ctacc                                           2605


<210> 2106
<211> 2713
<212> DNA
<213> Homo sapiens

<400> 2106
cactgggctt ggagtcagtg gcaataacca ggggcaataa ccaggcgtgt cccagggggg       60

agccccgctc tgcagccctg tgcgccgtag agagctggac ttaggctggc agcatggccg      120

agttcagggt cagggtgtcc accggagaag ccttcggggc tggcacatgg gacaaagtgt      180

ctgtcagcat cgtggggacc cggggagaga gccccccact gcccctggac aatctcggca      240

aggagttcac tgcgggcgct gaggaggact tccaggtgac gctcccggag gacgtaggcc      300

gagtgctgct gctgcgcgtg cacaaggcgc ccccagtgct gcccctgctg gggcccctgg      360

ccccggatgc ctggttctgc cgctggttcc agctgacacc gccgcggggc ggccacctcc      420

tcttcccctg ctaccagtgg ctggaggggg cggggaccct ggtgctgcag gagggtacag      480

ccaaggtgtc ctgggcagac caccaccctg tgctccagca acagcgccag gaggagcttc      540

aggcccggca ggagatgtac cagtggaagg cttacaaccc aggttggcct cactgcctgg      600

atgaaaagac agtggaagac ttggagctca atatcaaata ctccacagcc aagaatgcca      660

acttttatct acaggctggc tctgcttttg cagagatgaa aatcaagggg ttgctggacc      720

gcaaggggct ctggaggagt ctgaatgaga tgaaaaggat cttcaacttc cggaggaccc      780

cagcagctga gcacgcattt gagcactggc aggaggacgc cttcttcgcc tcccagttcc      840

tgaatggtct caaccctgtc ctgatccgcc gctgtcacta cctcccaaag aacttccccg      900

tcactgatgc catggtggcc tcagtgttgg gtcctgggac cagcttgcag gctgagctag      960

agaagggctc cctgttcttg gtggatcacg gcatcctctc tggcatccag accaatgtca     1020

ttaatgggaa gcctcagttc tctgcggccc caatgaccct gctataccag agcccaggct     1080

gcgggccgct gctgcctctc gccatccagc tcagccagac ccccggccca aacagcccca     1140

tcttcctgcc cactgatgac aagtgggact ggttgctggc caagacctgg gtgcgcaatg     1200

ccgagttctc cttccatgag gccctcacgc acctgctgca ctcacatctg ctgcctgagg     1260

tcttcaccct ggctaccctg cgtcagctgc cccactgcca ccctctcttc aagctgctga     1320

tcccgcacac ccgatacacc ctgcacatca acacactcgc ccgggagctg cttatcgtgc     1380

cagggcaggt ggtggacagg tccacaggca tcggcattga aggcttctct gagttgatac     1440

agaggaacat gaagcagctg aactattctc tcctgtgtct gcctgaggat atccggaccc     1500

gaggagttga agacatccca ggctactact accgtgatga tgggatgcag atctggggtg     1560

cagtggaacg ctttgtctct gaaatcatcg gtatctacta cccaagtgat gagtctgtcc     1620

aagatgacag agagctccag gcctgggtca gagagatctt ctccaagggc ttcctaaacc     1680

aggagagctc aggtataccc tcctcactgg agacccggga agccctggtg cagtatgtca     1740

ccatggtgat attcacctgc tccgccaagc atgcggctgt cagtgcaggg cagtttgact     1800

cctgtgcttg gatgcccaac ctgccaccca gcatgcagct gccaccaccc acctccaaag     1860

gcctggcaac atgcgagggc ttcatagcca ccctcccacc tgtcaatgcc acatgtgatg     1920

tcatccttgc tctctggttg ctgagcaagg agcctggaga ccaaaggccc ctgggcacct     1980

atccggatga gcacttcaca gaggaggccc ctcggcggag catcgccacc ttccagagcc     2040

gcctggccca gatctcgagg ggcatccagg agcggaacca gggcctggtg ctgccctaca     2100

cctacctaga ccctcccctc atcgagaaca gcgtctccat ctaaatccca ggggaacaca     2160

ggcccagatg acatcccttt gaccacatcg ctctaggata actggcaccc agagaaaagg     2220

actcctcaga aaaaacaggc ccccatgtgc ctctcctggg acaaccagac tctgtaactc     2280

acccccacca ccatacacac acacaaaaac agaaacaaaa tcaaaacaga gaaagcagaa     2340

aatctaccaa gaacagagtc tcaggacaga accactgagt cttttggagg ctccaagcct     2400

caaagtgccc gcagagccca ccttgagggt tttgctagtt ggttttgttt tgcgttttac     2460

agccgtgggg ggaagcacat aatcccgccc cagggcccac tagcatccac tgattggacc     2520

ttatggtcac ccaactcaag gacagccacc aagaagtggc tgccaaagag actgggcgca     2580

gtggctcatg cccataatcc cagcactttg ggagatggag gcgggaaaat catttgaggt     2640

cagaagttca aggccagcct ggacgacata gcgagactcc acctctacca aaaaataaaa     2700

attaaaaaac aaa                                                        2713


<210> 2107
<211> 3477
<212> DNA
<213> Homo sapiens

<400> 2107
ggctgccaac ggttttgagc gtagggggag gcgtgagagg gggatctcag gggaggaggt       60

caatcgcttg ccccccactt tggcaaattg gggactgagg actggaaggg tggagagtag      120

gcggaaccag gtggtcgtcg gggcagagga tctcgggcta ggcttgaggg cggcgtgctt      180

cttagggacg acttagggcg tgactgaggg ttcacaaggt ttcttttggg gtggtcggga      240

gggagagatt ctagggaaca aggaagctcg ctatggcttt cttgccagga ggggtcgaag      300

ggaaagtaca agggagctgg agctgaccct gggtagaacg ggtgaaggga tgggggagcg      360

tgaggttccg ccctctcttg agactggaac caattgaggg actagtaggg cagggggaca      420

gaaattgggc tcctagtgga tttgggtccg tttccgttgg gacgttttgg gtgtgagaac      480

ttaagagctc agttgaccgg ggatagcctg tgccggagtt gatctgcagc ttccagcact      540

cgtagtcggg aagaggagct tcagcagcgc tgttgtccca cagtaggtct tctgtccgca      600

cccgctctgc gctgcaccct cttaacgctg ttcccaggag ctggggaaag ggatgctttt      660

gcccactccc atggcccctg gaactggtgg aaacctttcc tctaaccaga aagcctcgat      720

atccttaatt caccaaggat ccttggcgtg gagtcttcct cccttctccc aagtctttct      780

ccgtgaactt ttcctcctgg actttgctaa agcagaacct cccagctctt tgctgtctcc      840

ggttgtctct tccctgtatt catggcaaca tcagctgaca gccccagttc acccctcggg      900

gcggaggatc tcctgagtga ttcatcagaa ccccctgggc tcaaccaagt gtcgtctgaa      960

gtgacctccc agctctatgc ttctttgcgc ctcagccggc aggcggaggc cacggcccga     1020

gcccagctgt atttaccctc cacctccccg cctcatgaag ggttagacgg cttcgcccaa     1080

gaattgagtc gaagcttgtc agtcggattg gaaaagaact tgaagaaaaa ggatggttct     1140

aagcatatct ttgagatgga aagtgttcgg ggtcagctcc agaccatgct ccaaacctca     1200

cgtgatacag cctatcggga tcctctcatt cctggcgctg gctcagagag acgggaagag     1260

gactcctttg acagtgatag cacagccacc ttgctcaaca cccggcccct gcaagacttg     1320

tctccatcta gctcagccca agccctggag gagctgtttc cccgctacac cagccttcgg     1380

ccagggcctc cactcaatcc cccagatttt caggggctga gagatgcatt ggattcagag     1440

catacccgcc gcaagcattg tgagcgccat attcagagcc tgcagacccg agtgttagag     1500

ctacagcaac aattagccgt ggctgtggct gccgaccgca agaaagatac catgattgaa     1560

caactggaca agaccctggc ccgtgtggtg gagggctgga accggcatga ggctgagcgg     1620

acagaggttc tcaggggact tcaagaggaa caccaggcag cagagctcac cagaagcaag     1680

cagcaggaga cagtaacccg cctggaacaa agcctttctg aggccatgga ggccctgaat     1740

cgtgagcagg aaagtgccag actgcagcaa cgggaaagag agacactgga ggaggaaagg     1800

caagctctga ctctgaggtt ggaggcagaa cagcagcggt gctgtgtcct gcaggaagag     1860

cgggatgcag ctcgggctgg gcaactgagt gagcatcgag agttggagac tcttcgggct     1920

gccctagaag aagaacggca gacctgggcc cagcaagagc accagcttaa ggaacactac     1980

caggcgctgc aggaggagag ccaggctcag ctggaaaggg agaaggagaa gagccagagg     2040

gaagcccagg ccgcctggga gacccagcac cagttggcat tggtgcagtc tgaggtgcgg     2100

cggctggaag gagagctgga tacagctcgg agagagagag atgccctgca gctggaaatg     2160

agcttggtgc aggcccggta tgaaagccag cggatccagc tggagtcgga gctggctgtg     2220

cagctggagc agcgggtgac agagcggctg gcgcaggctc aggagagcag cctacggcaa     2280

gcagcctccc tcagggaaca tcacaggaag cagctgcagg acctgagtgg acagcaccag     2340

caggagctgg ccagtcagct agctcagttc aaggtggaaa tggcagaacg agaggaacgg     2400

caacagcagg tggctgagga ctacgagctc aggctcctcc tgctggaccc tccagccccg     2460

ggcctcagga gcccgagaag gaggagagga gggtctggac tatgcctccc atggccgtgg     2520

ccctgaagcc tgtattgcag cagagccggg aagcaaggga cgagctacct ggagcgcctc     2580

ctgttctttg cagttcctcc tcagatctta gcctcctgtt gggcccctct tttcagagcc     2640

agcattcttt ccagcccctg gagcccaaac cagacctcac ttcatccaca gctggggcct     2700

tctctgcact tggggccttc catcccgatc atagggcaga aaggccattc cctgaggaag     2760

atcctggacc tgacggggag ggcctcctaa agcaagggct gccgcctgct cagctggagg     2820

gcctcaagaa ttttttgcac cagttgctgg agacagtgcc ccagaacaat gagaaccctt     2880

ctgtcgacct gttgccccct aagtctggtc ctctgactgt cccatcttgg gaggaagccc     2940

ctcaagtgcc acgtattcca ccgcctgtcc acaaaaccaa agttccctta gccatggcat     3000

ccagtctttt ccgggtccct gagcctccct cctcccattc acaaggcagt ggtcccagca     3060

gtggttcccc agagagaggt ggagatgggc ttacattccc aaggcagctg atggaggtgt     3120

ctcaactgtt gcgactctac caggctcggg gctggggggc tctgcctgct gaggatctcc     3180

tgctctacct gaagaggctg gaacacagcg ggactgatgg ccgaggggat aatgtcccca     3240

gaaggaacac agactcccgc ttgggtgaga tcccccggaa agagattccc tcccaggctg     3300

tccctcgccg ccttgctaca gcccccaaga ctgaaaaacc tcccgcacgg aagaaaagtg     3360

ggcaccctgc cccgagtagc atgaggagcc gggggggagt ctggagatga gcccccctac     3420

cctctctcct ctttgttctc tcattgttgt tattttaata aatgctcatt agtctgt        3477


<210> 2108
<211> 3770
<212> DNA
<213> Homo sapiens

<400> 2108
gtggtctcgc gggcgggtga cgtcatcgag gcgagagagg cggagccgtg gacagtgggc       60

gggaggctgc caacggtttt gagcgtaggg ggaggcgtga gagggggatc tcaggggagg      120

aggtcaatcg cttgcccccc actttggcaa attggggact gaggactgga agggtggaga      180

gtaggcggaa ccaggtggtc gtcggggcag aggatctcgg gctaggcttg agggcggcgt      240

gcttcttagg gacgacttag ggcgtgactg agggttcaca aggtttcttt tggggtggtc      300

gggagggaga gattctaggg aacaaggaag ctcgctatgg ctttcttgcc aggaggggtc      360

gaagggaaag tacaagggag ctggagctga ccctgggtag aacgggtgaa gggatggggg      420

agcgtgaggt tccgccctct cttgagactg gaaccaattg agggactagt agggcagggg      480

gacagaaatt gggctcctag tggatttggg tccgtttccg ttgggacgtt ttgggtgtga      540

gaacttaaga gctcagttga ccggggatag cctgtgccgg agttgatctg cagcttccag      600

cactcgtagt cgggaagagg agcttcagca gcgctgttgt cccacagtag gtcttctgtc      660

cgcacccgct ctgcgctgca ccctcttaac gctgttccca ggagctgggg aaagggatgc      720

ttttgcccac tcccatggcc cctggaactg gtggaaacct ttcctctaac cagaaagcct      780

cgatatcctt aattcaccaa ggatccttgg cgtggagtct tcctcccttc tcccaagtct      840

ttctccgtga acttttcctc ctggactttg ctaaagcaga acctcccagc tctttgctgt      900

ctccggttgt ctcttccctg tattcatggc aacatcagct gacagcccca gttcacccct      960

cggggcggag gatctcctga gtgattcatc agaaccccct gggctcaacc aagtgtcgtc     1020

tgaagtgacc tcccagctct atgcttcttt gcgcctcagc cggcaggcgg aggccacggc     1080

ccgagcccag ctgtatttac cctccacctc cccgcctcat gaagggttag acggcttcgc     1140

ccaagaattg agtcgaagct tgtcagtcgg attggaaaag aacttgaaga aaaaggatgg     1200

ttctaagcat atctttgaga tggaaagtgt tcggggtcag ctccagacca tgctccaaac     1260

ctcacgtgat acagcctatc gggatcctct cattcctggc gctggctcag agagacggga     1320

agaggactcc tttgacagtg atagcacagc caccttgctc aacacccggc ccctgcaaga     1380

cttgtctcca tctagctcag cccaagccct ggaggagctg tttccccgct acaccagcct     1440

tcggccaggg cctccactca atcccccaga ttttcagggg ctgagagatg cattggattc     1500

agagcatacc cgccgcaagc attgtgagcg ccatattcag agcctgcaga cccgagtgtt     1560

agagctacag caacaattag ccgtggctgt ggctgccgac cgcaagaaag ataccatgat     1620

tgaacaactg gacaagaccc tggcccgtgt ggtggagggc tggaaccggc atgaggctga     1680

gcggacagag gttctcaggg gacttcaaga ggaacaccag gcagcagagc tcaccagaag     1740

caagcagcag gagacagtaa cccgcctgga acaaagcctt tctgaggcca tggaggccct     1800

gaatcgtgag caggaaagtg ccagactgca gcaacgggaa agagagacac tggaggagga     1860

aaggcaagct ctgactctga ggttggaggc agaacagcag cggtgctgtg tcctgcagga     1920

agagcgggat gcagctcggg ctgggcaact gagtgagcat cgagagttgg agactcttcg     1980

ggctgcccta gaagaagaac ggcagacctg ggcccagcaa gagcaccagc ttaaggaaca     2040

ctaccaggcg ctgcaggagg agagccaggc tcagctggaa agggagaagg agaagagcca     2100

gagggaagcc caggccgcct gggagaccca gcaccagttg gcattggtgc agtctgaggt     2160

gcggcggctg gaaggagagc tggatacagc tcggagagag agagatgccc tgcagctgga     2220

aatgagcttg gtgcaggccc ggtatgaaag ccagcggatc cagctggagt cggagctggc     2280

tgtgcagctg gagcagcggg tgacagagcg gctggcgcag gctcaggaga gcagcctacg     2340

gcaagcagcc tccctcaggg aacatcacag gaagcagctg caggacctga gtggacagca     2400

ccagcaggag ctggccagtc agctagctca gttcaaggtg gaaatggcag aacgagagga     2460

acggcaacag caggtggctg aggactacga gctcagactg gcccgggagc aagcgcgagt     2520

gtgcgaactg cagagtggga accagcagct ggaggagcag cgggtggagc tggtggaaag     2580

actgcaggcc atgctgcagg cccactggga tgaggccaac cagctgctca gcaccactct     2640

cccgccgccc aaccctccag ctcctcctgc tggaccctcc agccccgggc ctcaggagcc     2700

cgagaaggag gagaggaggg tctggactat gcctcccatg gccgtggccc tgaagcctgt     2760

attgcagcag agccgggaag caagggacga gctacctgga gcgcctcctg ttctttgcag     2820

ttcctcctca gatcttagcc tcctgttggg cccctctttt cagagccagc attctttcca     2880

gcccctggag cccaaaccag acctcacttc atccacagct ggggccttct ctgcacttgg     2940

ggccttccat cccgatcata gggcagaaag gccattccct gaggaagatc ctggacctga     3000

cggggagggc ctcctaaagc aagggctgcc gcctgctcag ctggagggcc tcaagaattt     3060

tttgcaccag ttgctggaga cagtgcccca gaacaatgag aacccttctg tcgacctgtt     3120

gccccctaag tctggtcctc tgactgtccc atcttgggag gaagcccctc aagtgccacg     3180

tattccaccg cctgtccaca aaaccaaagt tcccttagcc atggcatcca gtcttttccg     3240

ggtccctgag cctccctcct cccattcaca aggcagtggt cccagcagtg gttccccaga     3300

gagaggtgga gatgggctta cattcccaag gcagctgatg gaggtgtctc aactgttgcg     3360

actctaccag gctcggggct ggggggctct gcctgctgag gatctcctgc tctacctgaa     3420

gaggctggaa cacagcgggt acaagcctgg gaggaaggag gaaggattct ccgggtggaa     3480

gctggattat ggggagtgga gtgggactga tggccgaggg gataatgtcc ccagaaggaa     3540

cacagactcc cgcttgggtg agatcccccg gaaagagatt ccctcccagg ctgtccctcg     3600

ccgccttgct acagccccca agactgaaaa acctcccgca cggaagaaaa gtgggcaccc     3660

tgccccgagt agcatgagga gccggggggg agtctggaga tgagcccccc taccctctct     3720

cctctttgtt ctctcattgt tgttatttta ataaatgctc attagtctgt                3770


<210> 2109
<211> 3781
<212> DNA
<213> Homo sapiens

<400> 2109
agcacttgaa gttcaggcag cgagagttga catggggcca gggctgcgcc cctggggcgg       60

gttgaagaca gggtgagtct cttgatattc aggaaatcat cgcgcaccca gtcaccagcg      120

ttcgggagcc tgtcgcagcg ggaccgacgg aatccggagc aggcgacagg gcgcagaagc      180

gggatgtact tctgttgggg cgccgactcc agggagctgc agcgccggag gacggcgggc      240

agccccgggg ctgagctact gcaggcggcc agcggggagc gccactctct gctgctgctg      300

accaaccaca gggtcctctc gtgcggagac aacagcaggg gtcagctggg ccgcaggggc      360

gcgcagcgcg gggagctgcc agaaccaatt caggcattgg aaaccctaat tgttgatctc      420

gtgagctgcg ggaaggagca ctccctggct gtgtgccaca aaggaagggt cttcgcatgg      480

ggagctggtt ctgaagggca gctggggatt ggagaattca aggaaataag tttcacacct      540

aagaaaataa tgactctgaa tgatataaaa ataatacaag tttcctgtgg acactaccac      600

tccctggcat tatcaaaaga tagccaagtg ttttcgtggg gaaagaacag ccatgggcag      660

ctgggcttgg ggaaggagtt cccctcccaa gccagcccgc agagggtgag gtccctggag      720

gggatcccac tggctcaggt ggctgccgga ggggctcaca gctttgccct gtctctctgt      780

gggacttcgt ttggctgggg aagtaacagt gccgggcagc tggccctcag tgggcgtaat      840

gtcccagtgc aaagcaacaa gcctctctca gtcggtgcac tgaagaatct aggtgtggtt      900

tatatcagct gtggtgatgc acacactgcg gtgcttaccc aggacgggaa agtgttcaca      960

tttggagaca atcgctctgg acagctggga tacagcccca ctcctgagaa gagaggtcca     1020

caacttgtgg aaagaattga tggcctagtt tcgcagatag attgtggaag ttatcacacc     1080

ctggcatatg tgcacaccac tggtcaggtg gtatcttttg gtcatggacc aagtgacaca     1140

agcaagccaa ctcatccgga ggccctgaca gagaactttg acattagctg cctgatttct     1200

gctgaagact tcgtggatgt tcaagtcaaa cacatttttg ctggaacata tgccaacttt     1260

gtgacaactc atcaggatac tagttccaca cgtgctcccg ggaaaaccct gccagaaata     1320

agccgaatta gccagtccat ggcagaaaaa tggatagcag tgaaaagaag aagtactgaa     1380

catgaaatgg ctaaaagtga aattagaatg atattttcat ctcctgcttg tctgactgca     1440

agttttttaa agaaaagagg aactggagaa acgacttcca ttgatgtgga cttagaaatg     1500

gcaagagata ccttcaagaa gttaacaaaa aaggaatgga tttcttccat gataactacg     1560

tgtctcgagg atgatctgct cagagctctt ccatgccatt ctccacacca agaagcttta     1620

tcagttttcc tcctgctccc agaatgtcct gtgatgcatg attctaagaa ctggaagaac     1680

ctggtggttc catttgcaaa ggctgtgtgt gaaatgagta aacaatcttt gcaagtccta     1740

aagaagtgtt gggcattttt gcaagaatct tctctgaatc cgctgatcca gatgcttaaa     1800

gcagccatca tctctcagct gcttcatcag actaaaaccg aacaggatca ctgtaatgtt     1860

aaagctcttt taggaatgat gaaagaactg cataaggtaa acaaagctaa ctgtcgacta     1920

ccagaaaata ctttcaacat aaatgaactc tccaacttat taaactttta tatagataga     1980

ggaagacagc tctttcggga taaccacctg atgtcagaaa agaaagcata catgcttatg     2040

catgaaacaa ttctgcaaaa aaaggatgaa tttcctccat cacccagatt tatacttaga     2100

gtcagacgaa gtcgcctggt taaagatgct ctgcgtcaat taagtcaagc tgaagctact     2160

gacttctgca aagtattagt ggttgaattt attaatgaaa tttgtcctga gtctggaggg     2220

gttagttcag agttcttcca ctgtatgttt gaagagatga ccaagccaga atatggaatg     2280

ttcatgtatc ctgaaatggg ttcctgcatg tggtttcctg ccaagcctaa acctgagaag     2340

aaaagatatt tcctctttgg aatgctgtgt ggactctcct tattcaattt aaatgttgct     2400

aaccttcctt tcccactggc tctgtataaa aaacttctgg accaaaagcc atcattggaa     2460

gatttaaaag aactcagtcc tcggttgggg aagagtttgc aagaagttct agatgatgct     2520

gctgatgaca ttggagatgc gctctgcata cgcttttcta tacactggga ccaaaatgat     2580

gttgacttaa ttccaaatgg gatctccata cctgtggacc aaaccaacaa gagagactat     2640

gtttctaagt atattgatta cattttcaac gtctctgtaa aagcagttta tgaggaattt     2700

cagagaggat tttatagagt ctgtgagaag gagatactta gacatttcta ccctgaagaa     2760

ctaatgacag caatcattgg aaatactgat tatgactgga aacagtttga acagaattca     2820

aagtatgagc aaggatacca aaaatcacat cctactatac agttgttttg gaaggctttc     2880

cacaaactaa ccttggatga aaagaaaaaa ttcctctttt tccttacagg acgtgatagg     2940

ctgcatgcaa gaggcataca gaaaatggaa atagtatttc gctgtcctga aactttcagt     3000

gaaagagatc acccaacatc aataacttgt cataatattc tctccctccc taagtattct     3060

acaatggaaa gaatggagga agcacttcaa gtagccatca acaacaacag aggatttgtc     3120

tcacccatgc tcacacagtc ataatcacct ctgagagact cagggtgggc tttctcacac     3180

ttggatcctt ctgttcttcc ttacacctaa ataatacaag agattaatga atagtggtta     3240

gaagtagttg agggagagat tgggggaatg gggagatgat gatgatggtc aaagggtgca     3300

aaatctcaca caagactgag gcaggagaat agggtacaga gatagggatc taaggatgac     3360

ttggacacac tccctggcac tgaagagtct gaacactggc ctgtgattgg tccattccag     3420

gaccttcatt tgcataaggt atcaaaccac atcagcctct gattggccat gggccagacc     3480

tgcactctgg ccaatgattg gttcattcca ggacattcat ttgcataagg agtcaaacca     3540

caccagtctt ggattggctg tgagccaatt cacctcagtc tctaattggc tgtgagtcag     3600

tctttcattt acatagggtg taaccatcaa gaaacctcta cagggtactt aagccccaga     3660

agattttgct accagggctc ttgagccact tgctctagcc cactcccacc ctgtggaatg     3720

tactttcact tttgctgctt cactgccttg tgctccaata aatccactcc ttcaccaccc     3780

a                                                                     3781


<210> 2110
<211> 675
<212> DNA
<213> Homo sapiens

<400> 2110
gtattttaca aactgagaaa gtagctccag cagcacccga gagggtcagg agaaaagcgg       60

aggaagctgg gtaggccctg aggggcctcg gtaagccatc atgaccaccc ggcaagccac      120

gaaggatccc ctcctccggg gtgtatctcc tacccctagc aagattccgg tacgctctca      180

gaaacgcacg cctttcccca ctgttacatc gtgcgccgtg gaccaggaga accaagatcc      240

aaggagatgg gtgcagaaac caccgctcaa tattcaacgc cccctcgttg attcagcagg      300

ccccaggccg aaagccaggc accaggcaga gacatcacaa agattggtgg ggatcagtca      360

gcctcggaac cccttggaag agctcaggcc tagccctagg ggtcaaaatg tggggcctgg      420

gccccctgcc cagacagtcc tggtcccagc tcctggaaag ctctttgctc ttagaagatc      480

tccctttcct ccagcaaaat gtcatctcgc caggtgccat ggcttgtacc tgtaatcaca      540

gctactcagg aggctgaagc aggaggatca ctggaggcca ggagttggag accagcctgg      600

atgacagagg gagatcccat ctctttaaaa aataaataaa taaataaata ataaatatca      660

cttcttctga agcct                                                       675


<210> 2111
<211> 683
<212> DNA
<213> Homo sapiens

<400> 2111
gcatgcgcgc cggcgaccac gcctaaatag ccgcagcctc tgcgcgtcgc cctccacggt       60

taccccggct ctccgcccct ccttctcgcg gcgctcgagg gaccatggcc gatcctcgcg      120

tgagacagat caagatcaag accggcgtgg tgaagcggtt ggtcaaagaa aaagtgatgt      180

atgaaaaaga ggcaaaacaa caagaagaaa agattgaaaa aatgagagct gaagacggtg      240

aaaattatga cattaaaaag caggcagaga tcctacaaga atccaggatg atgatcccag      300

attgccagcg caggttggaa gccgcatatt tggatcttca acggatacta gaaaatgaaa      360

aagacttgga agaagctgag gaatataaag aagcacgttt agtactggat tcagtgaagt      420

tagaagcctg aaacttttct cgtatggggt ggtttttgca ttaaatcctg gggtccattt      480

tacaatccat tatttttgac cactgctatg tgttcaagta gtatgagaat gtgattgttt      540

ttatctggtt acatatatat ttctttgtct aatttaatat gtcaaataaa tgagttcatc      600

taataaaatt gtttatttta tactttacaa aatttttaaa ttaacctttt atcattaaac      660

cacatagact ttatgacaga gaa                                              683


<210> 2112
<211> 1798
<212> DNA
<213> Homo sapiens

<400> 2112
tcattactac agggcaggaa gggcacgttc tcatcagcat gagggagtgc ctttccatcc       60

acatcggtca agctggcatc cagattgggg acgcctgctg ggaactctat tgcctggaac      120

atggaatcca gccaaatggc gttgttcttg acactcaaca ggatcagctg gaaaatgcaa      180

aaatggagca cacaaatgca tctttcgata ccttcttctg tgagacaaga gctgggaagc      240

atgtgcctag agcactcttc gtggacttgg agccaactgt tatagatggg atccggacgg      300

gccagcaccg ttcactcttc caccccgagc agctccttag cggaaaggag gatgctgcta      360

acaattacgc gcgaggccgt tactctgtgg ggtcggaggt catcgacctt gtgctggaga      420

ggacccggaa gctggcagaa cagtgtggtg gacttcaggg atttttgatt ttccgaagct      480

ttggaggagg cactggttca gggtttacgt ctctcttaat ggagaggctc acaggagaat      540

atagcagaaa gactaagctg gagttctcgg tctacccagc ccccaggatc tccactgctg      600

tggtagagcc ttataactct gtcctcacca cccactccac cacagagcac acggactgta      660

ccttcatggt ggacaacgag gccgtctatg atatatgcca tcgtaaactc ggtgttgaat      720

gcccctctca tgccagcatc aatagattgg tggttcaggt ggtatcttcc atcactgcct      780

ccctccggtt tgaagggccc ttgaatgtag acctaattga attccagacc aacctggtac      840

cttatccgag aatacatttc cccatgacag ccttcgcccc catcgtctct gctgacaaag      900

cctaccatga gcagttctct gtgtcagaca tcaccactgc ctgctttgag tcctccaacc      960

agctggtcaa gtgtgatcct cggcttggga agtacatggc ctgctgccta ctctatagag     1020

gggatgtggt ccccaaggaa gtgaatgcag caatcgcagc cacgaagtcg aggcactctg     1080

ttcagtttgt agattggtgt ccaactggtt tcaaggtggg catcaacaat cggccgccca     1140

cggtgatgcc gggtggggac ctggccaaag tccaccggtc catctgcatg ctgagcaaca     1200

ccacggcgat tgtggaggcc tgggcccgcc tggaccacaa gtttgacctc atgtacgcca     1260

agagagcatt tctgcactgg tacctcagag aaggcatgga agaagcagag ttcttggagg     1320

ccagggaaga tctggcagcc ctggagaggg actatgagga agtggcgcaa agtttctgag     1380

gcatgtatga tgggtgcaaa tgaatgtcaa gttaaaatgg catgttttct tttcaagccg     1440

ttatatgcct agtgggtagt tcccctgatg agcagaaaaa tgaactcaaa tcaggcaaga     1500

ctctaggttc cacactaaat taagtgggtc agtaccaaca atgaacacat tatttcctgg     1560

tctactggta caagtcagct ctgctacctg ggagcctttg gaagcttaga gtcctttgaa     1620

ctgctgagtc acttctaggt gggatttttt tgttttacca agagacaatg aaatcctgaa     1680

gtttatgctt ttcctttctg gtaccggaag tagaaaacag cacatgttga ttacgaatgt     1740

tttttccccc atgtctacat tttttacact gattaaatca taaatatttt cagtatga       1798


<210> 2113
<211> 1282
<212> DNA
<213> Homo sapiens

<400> 2113
cctcccgcct cctctaggcc gccggccgcg aagcgctgag tcacggtgag gctactggac       60

ccacactctc ttaacctgcc ctccctgcac tcgctcccgg cggctcttcg cgtcaccccc      120

gccgctaagg ctccaggtgc cgctaccgca gcccctccat cctctacagc tcagcatcag      180

aacactctct ttttagactc cgatatgggg tcctccaaga aagttactct ctcagtgctc      240

agccgggagc agtcggaagg ggttggagcg agggtccgga gaagcattgg cagacccgag      300

ttaaaaaatc tggatccgtt tttactgttt gatgaattta aaggaggtag accaggagga      360

tttcctgatc atccacatcg aggttttgaa acagtatcct acctcctgga agggggcagc      420

atggcccatg aagacttctg tggacacact ggtaaaatga acccaggaga tttgcagtgg      480

atgactgcgg gccggggcat tctgcacgct gagatgcctt gctcagagga gccagcccat      540

ggcctacaac tgtgggttaa tttgaggagc tcagagaaga tggtggagcc tcagtaccag      600

gaactgaaaa gtgaagaaat ccctaaaccc agtaaggatg gtgtgacagt tgctgtcatt      660

tctggagaag ccctgggaat aaagtccaag gtttacactc gcacaccaac cttatatttg      720

gacttcaaat tggacccagg agccaaacat tcccaaccta tccctaaagg gtggacaagc      780

ttcatttaca cgatatctgg agatgtgtat attgggcccg atgatgcaca acaaaaaata      840

gaacctcatc acacagcagt gcttggagaa ggtgacagtg tccaggtgga gaacaaggat      900

cccaagagaa gccactttgt cttaattgct ggggagccat taagagaacc agttatccaa      960

catggtccat ttgtgatgaa caccaatgaa gagatttctc aagctattct tgatttcaga     1020

aacgcaaaaa atgggtttga aagggccaaa acctggaaat caaagattgg gaactagtgg     1080

aaagcggaag agcaggtctt gatgtgtcct agaattttgc catttctgag attgagccat     1140

tgaaggcatt ccatttctaa agcttattta gccggtgctt ctaaagaatt ccacactaac     1200

gtgataacat ggtttttgta acaataaatg taggatattt cctggcacat gcaaataaac     1260

ctaatcattg tttctttaaa aa                                              1282


<210> 2114
<211> 1539
<212> DNA
<213> Homo sapiens

<400> 2114
accgaccgga gcgccgatca gagcacctgc ccgggccaca catttcctcc tggagcacag       60

caagtgccgc ctaaattacc cgagtgagca tctcttcccg gcacgagagg cagggaggcc      120

aaagggccgc caagctggcc tgggagaggc gtagggcgga gcgagagtgg agtgacattc      180

ccgagggcgg agccccaggg cctccgagac ccgtagactc ccgcctcccg cctcctctag      240

gccgccggcc gcgaagcgct gagtcacggt gaggctactg gacccacact ctcttaacct      300

gccctccctg cactcgctcc cggcggctct tcgcgtcacc cccgccgcta aggctccagg      360

tgccgctacc gcagcgtgag tacctggggc tcctgcaggg gtccactagc cctccatcct      420

ctacagctca gcatcagaac actctctttt tagactccga tatggggtcc tccaagaaag      480

ttactctctc agtgctcagc cgggagcagt cggaaggggt tggagcgagg gtccggagaa      540

gcattggcag acccgagtta aaaaatctgg atccgttttt actgtttgat gaatttaaag      600

gaggtagacc aggaggattt cctgatcatc cacatcgagg ttttgaaaca gtatcctacc      660

tcctggaagg gggcagcatg gcccatgaag acttctgtgg acacactggt aaaatgaacc      720

caggagattt gcagtggatg actgcgggcc ggggcattct gcacgctgag atgccttgct      780

cagaggagcc agcccatggc ctacaactgt gggttaattt gaggagctca gagaagatgg      840

tggagcctca gtaccaggaa ctgaaaagtg aagaaatccc taaacccagt aaggatggtg      900

tgacagttgc tgtcatttct ggagaagccc tgggaataaa gtccaaggtt tacactcgca      960

caccaacctt atatttggac ttcaaattgg acccaggagc caaacattcc caacctatcc     1020

ctaaagggtg gacaagcttc atttacacga tatctggaga tgtgtatatt gggcccgatg     1080

atgcacaaca aaaaatagaa cctcatcaca cagcagtgct tggagaaggt gacagtgtcc     1140

aggtggagaa caaggatccc aagagaagcc actttgtctt aattgctggg gagccattaa     1200

gagaaccagt tatccaacat ggtccatttg tgatgaacac caatgaagag atttctcaag     1260

ctattcttga tttcagaaac gcaaaaaatg ggtttgaaag ggccaaaacc tggaaatcaa     1320

agattgggaa ctagtggaaa gcggaagagc aggtcttgat gtgtcctaga attttgccat     1380

ttctgagatt gagccattga aggcattcca tttctaaagc ttatttagcc ggtgcttcta     1440

aagaattcca cactaacgtg ataacatggt ttttgtaaca ataaatgtag gatatttcct     1500

ggcacatgca aataaaccta atcattgttt ctttaaaaa                            1539


<210> 2115
<211> 1975
<212> DNA
<213> Homo sapiens

<400> 2115
agattgctga aacaaaggac caatgcccag ggcggtcctt aattcctccc tgcagtttga       60

aactgtcagg ttgccgtcta ggtagcggtt gtgcttgctg aggctgcact tgctgacact      120

gcagctgcga cgcggctaag aggcgcagag cgaggagtcg ggatttggtc gcgagcggcg      180

acgagcattt gtgcagaatg tcatcagatg aggagaaata ctcacttcca gttgtgcaaa      240

atgactccag tcgaggcagt tctgtctctt cgaatcttca ggaagaatat gaagaactgc      300

ttcattatgc tatagtgact ccaaatattg aaccctgtgc ttcacagtca tctcatccta      360

agggagaatt ggtgccagat gtcagaattt ctacaattca tgatattctt catagtcaag      420

gaaataactc tgaagtaaga gaaactgcaa tagaagttgg aaaaggatgt gatttccata      480

tttcaagtca ttcaaagaca gatgagtcat caccagtgtt atcgccaagg aagccttctc      540

acccagtcat ggattttttc agttcacatc ttttagctga ctcttcctca ccagcaacaa      600

attctagtca tacagatgcc catgaaatac ttgtgagcga ttttcttgtt tctgatgaaa      660

accttcagaa gatggaaaat gtgcttgatc tttggagttc aggtcttaag acaaacatca      720

tatctgaact aagtaaatgg agacttaatt ttattgactg gcaccgaatg gaaatgagaa      780

aagagaaaga aaaacatgca gcacatttaa aacaactgtg taatcagatc aatgaattga      840

aggagctgca aaaaaccttt gaaatctcca ttgggagaaa agatgaggtg atttctagct      900

tgtctcatgc cataggcaag caaaaggaaa agatagagtt gatgagaaca ttcttccact      960

ggcgaatcgg ccatgtcaga gccagacagg atgtttatga aggtaaacta gctgaccagt     1020

actaccagag aactttactg aagaaagtct ggaaagtctg gcgttccgta gtgcaaaagc     1080

agtggaaaga tgtggtagaa agagcttgtc aagcaagagc tgaagaagtt tgtatccaga     1140

tttccaatga ttatgaagcc aaagttgcta tgttatctgg agctttggaa aatgcaaaag     1200

ctgagattca aagaatgcaa catgaaaaag agcactttga agattccatg aaaaaagctt     1260

tcatgagggg tgtatgtgca ttaaatcttg aagccatgac tatatttcaa aacagaaatg     1320

atgcagggat agactccaca aataataaaa aggaagagta tggtcctggt gttcaaggaa     1380

aagaacattc tgctcatttg gatccttcag ctcctccgat gcccttacca gttacatcac     1440

cactgctgcc atccccacca gccgccgtcg gaggagccag cgcgactgcc gttccctcag     1500

ctgcttcgat gacttctacc agggctgctt ccgcatcttc tgttcacgtt cctgtttctg     1560

ctcttggtgc aggatctgca gctactgctg catcagaaga aatgcaaacc attcctcaag     1620

caactgcagc aaaatatccc cggaccattc atcctgaaag tagtacctca gcttccagat     1680

cacttggaac cagatcagct cacacccagt ctctcacaag tgttcattcc ataaaagtgg     1740

ttgactaaag tgaatatgtc catagtgggg tcttttaatc cctctggtct taccaagggt     1800

tagaagtctt ttggttttaa cttttccata ttgttagaac atcatggaga catcatgttc     1860

atctgttcaa aattacaaga ggctttttca agctctacca tgctttgtaa ctatatgtag     1920

aaattatttt aatgttattt tttatttaag caattaagta aaactttttt aaatt          1975


<210> 2116
<211> 1682
<212> DNA
<213> Homo sapiens

<400> 2116
agtcgccccg gcaacagccg cctccctcgc gtcccccact ccccctctgt ctctccaagg       60

aaaactaggc ccctgcgcgg ccaacgccca ggatccgcaa gctgcgcgcc cacgagctcc      120

accagcccat tggagaaaag ttactgttca gtccctgaag gcttgtgcca taaaagagtg      180

ggagacattc ccagggaggt gaggaatgaa agatcgaatt aaagaccatt aaagaccaaa      240

gggcatctaa atctgcagca accatcagct ctcttttctt tgagagtttc agcacccatt      300

tggactttca caatcagaga tggcagcggt aaaggcatca acatcgaaag ctaccaggcc      360

ttggtattct catccggtat atgcaagata ctggcaacat tatcatcaag caatggcttg      420

gatgcaaagc catcacaatg cctacaggaa ggccgtggaa tcctgtttca atcttccatg      480

gtacttacct tctgcgcttc ttccccaaag ctcttacgat aatgaggctg cgtatcctca      540

gtccttctat gaccatcatg tggcctggca ggactacccc tgcagttctt cacatttcag      600

aagatctggg cagcatccac gttacagcag taggatccag gcatccacaa aagaagacca      660

agctttgtcc aaagaggaag agatggagac tgagtcagat gcagaggtag aatgtgacct      720

gagcaatatg gaaatcactg aagagctccg ccagtacttt gcagagaccg agaggcatag      780

agaagaacga cggcggcagc agcagctgga tgcagagcgc ctggacagct atgtgaacgc      840

tgaccacgac ctgtactgca acacccgccg gtcggtagaa gccccaactg agaggcctgg      900

tgagcggcgc caggccgaga tgaagcgttt gtacggggac agtgctgcca agatccaagc      960

catggaggcc gcggtgcagc tgagctttga caagcactgt gaccgaaagc agcccaagta     1020

ctggccggtc atccccctga agttctgagc tcagggcaca gggtacccag cctctccttc     1080

ttccttttgg gtacacgctc tttatctctc cttctgtaca tttcttaggg aaaggggact     1140

ttgtactggg gtacaggcat gttcaccaca gtcccagtgg gcctgtcacg gggtggatgt     1200

actatgccag ccacttggag gtctgcagga catgttctgt tgccaacatg ataaattttc     1260

tcctgacata aaataatttt gcatatacta tactggtttt ttatgttgtt ggtaacagtt     1320

caattcatta acgttcttgc ctagagatac tgcctggtgt tttgcttttt tatcttttct     1380

tgtctttaac ctgtctgaac tacacaaatg cctttaaaaa accagatatc ctctctgact     1440

ctagctccat tagcccccac taaaaatgag ccaagtgtgt agtgagacaa ataccactac     1500

ctgtagtgga gagggatgca tgttctataa agggccagag agtgaatatc tttggcactg     1560

caagccacac ggtcagtgtt gtgactactc aaccctccct ttgtagtgtg aaagcagctg     1620

tagacagtaa gtaaacaaat gggtgtggct gtgttctaat aaaactttat ttataaaaac     1680

ag                                                                    1682


<210> 2117
<211> 3306
<212> DNA
<213> Homo sapiens

<400> 2117
gggcgcccga gccggctgct cgtgccatgg agcggagtcc cgacgtgtcc cccgggcctt       60

cccgctcctt caaggaggag ttgctctgcg ccgtctgcta cgaccccttc cgcgacgcag      120

tcactctgcg ctgcggccac aacttctgcc gcgggtgcgt gagccgctgc tgggaggtgc      180

aggtgtcgcc cacctgccca gtgtgcaaag accgcgcgtc acccgccgac ctgcgcacca      240

accacaccct caacaacctg gtggagaagc tgctgcgcga ggaggccgag ggcgcgcgct      300

ggaccagcta ccgcttctcg cgtgtctgcc gcctgcaccg cggacagctc agcctcttct      360

gcctcgagga caaggagctg ctgtgctgct cctgccaggc cgacccccga caccaggggc      420

accgcgtgca gccggtgaag gacactgccc acgactttcg ggtgaggagc ctgatagccg      480

aagagagaag gaacttttta ccaactcacc agtggatagt gacaaagaca aggctccaaa      540

ccagctctcc taaccttcag tccaggaggc aaggccaagt gcaggaacat ggagcatgca      600

ctgcgggaga aggccaaggc cttctgggcc atgcggcgct cctagatgcc atggccgagg      660

agacaaggca gaagcaactt ctggccgacg agaagatgaa gcagctcaca gaggagacgg      720

aggtgctggc acatgagatc gagcggctgc agatggagat gaaggaggac gacgtttctt      780

ttctcatgaa acacaagagc cgaaaacgcc gactcttctg caccatggag ccagagccag      840

tccagcccgg catgcttatc gatgtctgca agtacctggg ctccctgcag taccgcgtct      900

ggaagaagat gcttgcatct gtggaatctg tacccttcag ctttgacccc aacaccgcag      960

ctggctggct ctccgtgtct gacgacctca ccagcgtcac caaccatggc taccgcgtgc     1020

aggtggagaa cccggaacgc ttctcctcgg cgccctgcct gctgggctcc cgtgtcttct     1080

cacagggctc gcacgcctgg gaggtggccc ttggggggct gcagagctgg agggtgggcg     1140

tggtacgtgt gcgccaggac tcgggcgctg agggccactc acacagctgc taccacgaca     1200

cacgctcggg cttctggtat gtctgccgca cgcagggcgt ggagggggac cactgcgtga     1260

cctcggaccc agccacgtcg cccctggtcc tggccatccc acgccgcctg cgtgtggagc     1320

tggagtgtga ggagggcgag ctgtctttct atgacgcgga gcgccactgc cacctgtaca     1380

ccttccacgc ccgctttggg gaggttcgcc cctacttcta cctggggggt gcacggggcg     1440

ccgggcctcc agagcctttg cgcatctgcc ccttgcacat cagtgtcaag gaagaactgg     1500

atggctgagc tggcccgggg ctgccccggt cttgtgccac agcactgttt tctttctgcc     1560

ctcttcctaa tgcccacact gcttgggcac tattgcgccc ctgcctcctt gccaggctct     1620

tcctcctgtc ctgcctggtc cttttccatg actccaggct gtgcctctct ccatgtttgg     1680

tcccttctgt gcccatggtc aggagctatt cgggtggcac ctcgctggcc aggctctccc     1740

gagtcgtggc acctccacaa tgtgaatttt ctgaatccct attccaggat ttctgggaat     1800

aatgtttact tctagaatgg gcctgttgta aaccatctca tcgaggtgtg gtaaagccat     1860

tggatgagga ggggactgcc atggaaagga gagtttgtta cttacggttc tgagaggagg     1920

ggccacatag gaaagcccca cggtgggtca gaaggcggaa ggagggaggg gaacgtgtgg     1980

gcaagagact tcctctggtt tcctcaggag gaaatgggca aggcagagta agcaggggag     2040

acaggtttaa gggtagctgg cttgagtaat ttcagtggct ctcaggatag gggctgccct     2100

ttttgtctga tacctggccc cgggatagtc aggacaggtg aatgttggcc tggggtgtga     2160

cagccctggg agagccatgt gaaggaggca gctggcgcca tcgctccgga ttagttggtt     2220

tccataggaa aggcatgctt tcagccagat gcttgccatc tctagggatt gggggattgg     2280

ctagcctggg aggatcagtc tgtccaggtc agcgaggccc cagataccag agcatcaaga     2340

gtacaggaaa tacagttaat gcagggcctc tgtgtggctg gatcctccgt ctccatcaga     2400

tcagctctga ttgatctatt cttgcacgat ttcctctgaa cacagggttc cagagtactt     2460

aaacacaaca ttttttaaat cgtgatttcg gcctatttcc ttgccaggcc tgtttcccca     2520

ccaggaaatg agataggagg actggatgag gatgtcctgt tatagttgct gtggaggaag     2580

ttcctctggt taattctcat cagcgtctgc agaaaagaag gaaagagggc acccttttca     2640

gttgggaaga aaggagaggg gtggcgccat ggacgtggcc ctaaacgctg tgggagaggg     2700

aagaggaggc tgggcctcgc tgccctcttg tctctgctga cttcagcctg gtcatgcttg     2760

ctctgccact tgcgatttca tccctaattt cttcctccac catgcctgca gacttttccc     2820

tgggcttgtt ttttctcgca catctctgaa gagtttttaa tcttcagctc atcatgtccc     2880

aggaagtggc atcataaaag gaaatatttt tttttcctag gagcagtgtt aaaatctggg     2940

tcacattcct gaccaaggac agcatcctgc cttctgccca tccccttcag ttcacaaaag     3000

ctgacatttt aaacaaatca tgactcacac gtattaattg gttataaata tgttgtgtac     3060

actggttaga taaaacttaa ggccacaagg agggcccagg taggcgatgt cagtgtgtga     3120

aggggctgga ttgggcgtgg tgaggatgtt ggcaaaccag tgcatgcacc tggttggaag     3180

atgctcagcc tcacaaaagc tccaagccct ttgggagcca aagtgtctga gagtgtgacc     3240

ctctcctgta aagtatttat cccacccatt aatataattt ctgtataata aacttgacct     3300

gaaatt                                                                3306


<210> 2118
<211> 7551
<212> DNA
<213> Homo sapiens

<400> 2118
cggccgcggc tgccatggca acactacgcc gccgccgcct tttcacgcac gtcgcgagct       60

aacggactcg gcggcggcgg cggcggcggc ctgcgcccca cccgcacccc atctggaccg      120

catcgctgaa tgtgcccgga cctgcgcctt ctgggtctct gaaagaagat gaatttggct      180

gagatttgtg ataatgcaaa gaaaggaaga gaatatgccc ttcttggaaa ttacgactca      240

tcaatggtat attaccaggg ggtgatgcag cagattcaga gacattgcca gtcagtcaga      300

gatccagcta tcaaaggcaa atggcaacag gttcggcagg aattattgga ggaatatgaa      360

caagttaaaa gtattgtcag cactttagaa agttttaaaa ttgacaagcc tccagatttc      420

cctgtgtcct gtcaagatga accatttaga gatcctgctg tttggccacc ccctgttcct      480

gcagaacaca gagctccacc tcagatcagg cgtcccaatc gagaagtaag acctctgagg      540

aaagaaatgg caggagtagg agcccgggga cctgtaggcc gagcacatcc tatatcaaag      600

agtgaaaagc cttctacaag tagggacaag gactatagag caagagggag agatgacaag      660

ggaaggaaga atatgcaaga tggtgcaagt gatggtgaaa tgccaaaatt tgatggtgct      720

ggttatgata aggatctggt ggaagccctt gaaagagaca ttgtatccag gaatcctagc      780

attcattggg atgacatagc agatctggaa gaagctaaga agttgctaag ggaagctgtt      840

gttcttccaa tgtggatgcc tgactttttc aaagggatta gaaggccatg gaagggtgta      900

ctgatggttg gacccccagg cactggtaaa actatgctag ctaaagctgt tgccactgaa      960

tgtggtacaa cattcttcaa cgtttcgtct tctacactga catctaaata cagaggtgaa     1020

tctgagaagt tagttcgtct gttgtttgag atggctagat tttatgcccc taccacgatc     1080

ttcattgatg agatagattc tatctgcagt cgaagaggaa cctctgatga acatgaggca     1140

agtcgcaggg tcaagtctga actgctcatt cagatggatg gagttggagg agctttagaa     1200

aatgatgatc cttccaaaat ggttatggta ttggctgcta ctaatttccc gtgggacatt     1260

gatgaagctt tgcgaagaag gttagaaaaa aggatatata tacctctccc aacagcaaaa     1320

ggaagagctg agcttctgaa gatcaacctt cgtgaggtcg aattagatcc tgatattcaa     1380

ctggaagata tagccgagaa gattgagggc tattctggtg ctgacatcac taatgtttgc     1440

agggatgcct ctttaatggc aatgagacgg cgtatcaatg gcttaagtcc agaagaaatc     1500

cgtgcacttt ctaaagagga acttcagatg cctgttacca aaggagactt tgaattggcc     1560

ctaaagaaaa ttgctaagtc tgtctctgct gcagacttgg agaagtatga aaaatggatg     1620

gttgaatttg gatctgcttg aatttctgtc agctctttaa tttctggtat ttttgttgat     1680

aaaatacgaa gaaattcctg caatttttaa aaaacaagtt tggaattttt ttcagtggag     1740

tggttttcgc ttaaaggaaa aaaaaatcta aaactgcgaa gaatactaaa tgtagttgag     1800

aaataattga tggcgagagt ttgctagtct ccctccccgg ctttgtgctg gtattccacg     1860

tattcctgca ttaatattgc acacccaaac cagtctatca gggaggctga agcaagggcg     1920

cagtgtgata ttttaggaat acagaagatt tagaaatacc cctatttctc atttgcagtt     1980

tttttttcca attctgtgct ctgtcaacat gagggaccta tctatgtatg ttgactttta     2040

acatcaaaat tggatttgtg tcaaacattc attgttaaga gaagaatgac agtatatttt     2100

ggaggaaata atgaatttac taattaaacc tttagaattt atgacttact gttagagtct     2160

gtcatatggt tagaattttt acttccgcta cccctgccat ttcttctgct agctacttca     2220

taatatcttg agctttactg aggaatattc tcacgctctg tggtatttga atcattttgc     2280

caggtcattt ctctgtcttt agtatttttt gctggtgctt cttacattta atatggaaag     2340

gtgggaagaa tattactgca ttagatgtaa ttcttcattc tagacttcca agtttgtttt     2400

cacttttttg tgtgtgcgtg aaggagtctg tgtcacccag gctgtgtagt gcagtggttg     2460

atcttggctc actgcaacct ctgcctccta gattcaagca attctcctgt ctcagcctcc     2520

caagtagctg ggattacagg tgcgcaccac catgcctggc tgtgttttca cttttctttc     2580

aacatgttca accagatata tagccattat ttttctcagc tccagcattg tttgattttt     2640

cttgagtttg attttagtat ttgagataaa tacttttaca ttctaaacaa gtccactctc     2700

tgtggctaac gcaaaacaaa tgaaatcttt attgttttcc aaacagctag tttaacaaaa     2760

cagcatcata catagtgaat gatgttcatt ggaaaattct aaaatttgtc cttgtctagg     2820

ttgagaactt ttacacacac taagataaag atagaaatct gacatgctca ctcaattcag     2880

caggaattac acattagaaa gaagccagaa aaataaatgg catatatcca atcacaagta     2940

aatgatcctg gcgttagttt ttatgattac atgtgtctca ttaggcaatt tatgctttaa     3000

tggtcaagct tttaaaaatt tgtatttgat aacatcctga attctcagtt tcgaatagtg     3060

cctactggtt taaaactaaa aataatacag ctttttggac atttaaccaa gatactaaga     3120

aggttttttt taaaaaaaga gatttgatta tttttccctg ctaaaaactg taaatgcctt     3180

atgttctttt cagataactt aagtctgacc taaactccag tattcatctg atgctgtaaa     3240

ttgcccttct ttctgagaca cagattataa gatgccagat cataagacat catgatttta     3300

ttgtaattga attcttccta aaaattgaga ggtttccttt tattaacttt taaaataaag     3360

aaataagtag tttcattacg attattttgc aaactattgc cagtcagaaa tgcacttttt     3420

ttttccctga agttttagga gccgtcacta aaacattagt cttgtgattg ttaaaacttg     3480

tttgtaatgg gttggtgcaa aagtaattgt ggtttttcca ttactttcaa tggcaaaaac     3540

cgcaattact tttgcaccag cctaacaata gttgattagt tagacctttt ctgggttttg     3600

tattgattat cttggtgtgc atttaattat ttttctgaat tcttcatgga taatgacata     3660

gtaattgtga ttcttttaat accagttaag cagtatttgg caacttaaac ttcctgggag     3720

cctaacttta ctatgttaag tgagtcaggt gtgcttttta tttcccttgt ttctcatttt     3780

gccctgtcag tggatggtag atgctttgta tatcttaaat cccttaaagg atcttaaaga     3840

catccctcag gtgttctatt taacttttat tttattttat tttatttatt tatttatttt     3900

gagactgagt cttgctctgt cgcccaggct ggagtgcagt ggcatgatct cggctcactg     3960

caacttctgc ctcccaggtt caagccattc tcctgcctcg gcctcctgag tagctgggat     4020

tacagttgcc gccacacccg gcttattttt ttgtattttt agtagaggca gagtttcacc     4080

atgttggcca ggctagtctc gaactcctga cctcagatga tccgcccaca ttggcctccc     4140

aaagtgctgg gattacaggt gtgatccacc gcacctggcc ctaactttta atatacaaca     4200

cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacactattt     4260

cagaagacag tgtgttgcct tacccagaat gagtgctagg attacaggcg tgagacagac     4320

acacatacac acacatacac acacacagag tctttattgc agaagacagt gtgttgcctt     4380

ataggcgtga gacacacaca cacacacaca cacacacaca cacacacaca gtctttattg     4440

cagaagacag tgtgttgcct taccagaatg agtgcttgga ttacaggcgt gagccactgt     4500

gcccagccct aacttttaat gtacatcaca cacacactca cactcacata cacacacaca     4560

cacacactct gactgtcttt attgcagaag acagtgtgtt gccttaccca gaatgagatt     4620

gaattgtttt gcttcgtttt gttttgttat tcagtgttgc ggtagcagat gcattatcaa     4680

aggaaaaata tttggctcct ttaattcctc tgaaaacatg agtattttga gttctgcagc     4740

acaatgactg taggactaag ctaagtctgc tttgcagata tctgatcaga tagtcccttc     4800

attctgtaga cgtgtattgg ttggtccaag acacagtgag taggagctct gtggaccaag     4860

acaaagctgg actagagagt acagttcaaa cttggcagtt tctctaacga ctctgtatag     4920

cttctggctt ctactactga aacaagagtt tagatcactg atggagaggc atagtaatct     4980

gtttgtgctt tggaaaaata tataaaagtt tttttcccct attttttgca ctttaaatct     5040

gttttgaaat tagaactgat atacatttat ttgaataatg tgtaactatt atggatctat     5100

tttaatgaac aatttttacc atttcccaag ctgcctgttt attataagca tgacatgttt     5160

actataaacc ttttgccccc ataatttctt tttttaaagg aaattaatat tagtaaaata     5220

aacacctctt taatggaagc tgcaaccttc tagtgatcca agtagacaat agatggtggc     5280

atcacagact ttatctacac actttcgggt ctgaccacta cctcccacaa tacctagcca     5340

ttttggaagg ggaaaacatg cggtggtcta gctgtatagc tcagggctta atttcagctt     5400

ctgagattgt gatgtcatat ttcactctca aaacataggc tgaaagcacg aattactcaa     5460

aaagtaagca aaccaatacc tggtgaatct atggacagtc atacacatac atcaggggaa     5520

aatgtgtgtg tacaacccaa atttacagta tgattgtcat tctttgactt tgttttgtat     5580

agcctgactc tgttgaacat gaaattatta gtactctagg ttttggacag cttgagttca     5640

tttgaattcc ttccttagga ataagttttt atatacactg ctaaatgtgt gatgagaatc     5700

ataaaacact aaccagctga ggtagctgtg attcactttc cccccaccct aacttgagat     5760

aaaatgaagg actaggcaag tatttcatgt tgtgtgagtg gacttcggtt ccttcagtat     5820

tgtctaggtt attgagtctt tctttgccta atagtggatt cccactctta agataacttt     5880

tattagtgat aaatcagttt agggtatatt ctgtatgaca ggcataaaat gttaagggtg     5940

aatgctggcc ttttccaaga aaaggccacc ttaacttgta tgaggaaaaa atcctaacta     6000

ttctcttttt tgtatctttt tttccgtaac tgttttgatt gtatatttta aagaaaccac     6060

ttaatttgtg atgcacgtaa tatttgtgtg aacctgagaa tatgtcacaa taggaaaaag     6120

cagaaattat acttagggga catgttaggg gggtaaaaat atttaagcct cgaatgtttt     6180

actgtcatct ccactaacta tttttacaga aaaagctaaa aactctgttg taattattgt     6240

aagtttactt atttatactt ttaaattagg cttttcatac ttaaattttt ttgacatttg     6300

cttttaatat ttgtttctta atgtggaaat tgtgtatttt aataatcaaa ttattaggat     6360

aatagatata tttttaaaca ttcacctcat taacaaatag atctttgaat ttttattagg     6420

ttttttggct ccagacaact gtttagcttt aatgatattt ctaaattccc agtgacttat     6480

taataaaaac aggaaaaata tttaggtaat gtcataaaat ttattttacc tttctcattt     6540

tctgagaaaa taaatgaaaa aaaccctaga tattgcttta ttaccaacag tgtgtaggtt     6600

tttgtacata tggaaatttg acacaaaaaa atagggaatt tgtatagaga agtttccctc     6660

ttataaaagg actcccattt gattgttcga aactataaaa tgcactttta ctttaccata     6720

tctgaaatga caaaatatcg ccctttggaa aacctgactc tttgcacgtg taattcccag     6780

agtctacctc agttaaccag gcttagtttt aggcaggaat gaattgaatt aaattcagtt     6840

catcatctat gcagatttgt ttcttttaag cacatccttc cctcctgctg ttgccctcct     6900

cccattaact tttcttttta atcttgaaat tgtttaaaat attccatctt tctttctcta     6960

gcaaagtgtt tgtattccaa ataaggcctc tgtgaaatgt ctgaattact tttcccgtct     7020

ttgttatggt cagcttcatt atttggatgt attgcattca aagcagcagt tccaaacata     7080

acacacatct attttcttag agttttgtaa atacaaacta acctgatgac attaaaaatt     7140

gtggatccta catgttccta tgttcattct ctaaaaacct gagtaacttt atgaaaacac     7200

acaaacctgg aaaaacatca catttttgtc acatttttac tgacaaatgt atattcatat     7260

gatggtacgg cagcagggag tggcccccag ttaacatggc tgtgagtgga cacagtgtct     7320

cgcaggatca ctgcatgtta tgatggcttg taagtgcgtt gttaagactt ttgtttcagt     7380

gtttgtctcc cagtatttga acctaattta aagaaaaaga cgtttccaag ttgtatttat     7440

taaatgtgtt tttccttacc ttttgtgctg ctactttgct aatctcatta gcttagctgt     7500

gtttgtgcat aggttatatt tggtaataaa tttatagagt gttggttgtc a              7551


<210> 2119
<211> 1634
<212> DNA
<213> Homo sapiens

<400> 2119
gacagaaaaa aaaatctctc tttgtcttga gggggctgtt gagtggtcgc ggacctgggc       60

tctgtgcgtt gggaaaggga agtggaggtc tctgaaagaa gatgaatttg gctgagattt      120

gtgataatgc aaagaaagga agagaatatg cccttcttgg aaattacgac tcatcaatgg      180

tatattacca gggggtgatg cagcagattc agagacattg ccagtcagtc agagatccag      240

ctatcaaagg caaatggcaa caggttcggc aggaattatt ggaggaatat gaacaagtta      300

aaagtattgt cagcacttta gaaagtttta aaattgacaa gcctccagat ttccctgtgt      360

cctgtcaaga tgaaccattt agagatcctg ctgtttggcc accccctgtt cctgcagaac      420

acagagctcc acctcagatc aggcgtccca atcgagaagt aagacctctg aggaaagaaa      480

tggcaggagt aggagcccgg ggacctgtag gccgagcaca tcctatatca aagagtgaaa      540

agccttctac aagtagggac aaggactata gagcaagagg gagagatgac aagggaagga      600

agaatatgca agatggtgca agtgatggtg aaatgccaaa atttgatggt gctggttatg      660

ataaggatct ggtggaagcc cttgaaagag acattgtatc caggaatcct agcattcatt      720

gggatgacat agcagatctg gaagaagcta agaagttgct aagggaagct gttgttcttc      780

caatgtggat gcctgacttt ttcaaaggga ttagaaggcc atggaagggt gtactgatgg      840

ttggaccccc aggcactggt aaaactatgc tagctaaagc tgttgccact gaatgtggta      900

caacattctt caacgtttcg tcttctacac tgacatctaa atacagaggt gaatctgaga      960

agttagttcg tctgttgttt gagatggcta gattttatgc ccctaccacg atcttcattg     1020

atgagataga ttctatctgc agtcgaagag gaacctctga tgaacatgag gcaagtcgca     1080

gggtcaagtc tgaactgctc attcagatgg atggagttgg aggagcttta gaaaatgatg     1140

atccttccaa aatggttatg gtattggctg ctactaattt cccgtgggac attgatgaag     1200

ctttgcgaag aaggttagaa aaaaggatat atatacctct cccaacagca aaaggaagag     1260

ctgagcttct gaagatcaac cttcgtgagg tcgaattaga tcctgatatt caactggaag     1320

atatagccga gaagattgag ggctattctg gtgctgacat cactaatgtt tgcagggatg     1380

cctctttaat ggcaatgaga cggcgtatca atggcttaag tccagaagaa atccgtgcac     1440

tttctaaaga ggaacttcag atgcctgtta ccaaaggaga ctttgaattg gccctaaaga     1500

aaattgctaa gtctgtctct gctgcagact tggagaagta tgaaaaatgg atggttgaat     1560

ttggatctgc ttgaatttct gtcagctctt taatttctgg tatttttgtt gataaaatac     1620

gaagaaattc ctgc                                                       1634


<210> 2120
<211> 1749
<212> DNA
<213> Homo sapiens

<400> 2120
aaaatcccat ggtgtccatt cggttaaagc ccatgttatt tctctcccag ttacctgcca       60

aatcttctgt ttagtgctgt ggtaaatttc acctttattt acttactaaa accatgctga      120

caagcataat tagagagaca ttatttttat aggacatctg aaattccaac gggcactact      180

atggtgcaag tcaccattat catctatggg ataactccaa aatcccatat tcactttagg      240

tttaccatca gcttttgact ggatactggc aaaaccacct tggtcacaat agtgctttgt      300

gacataccat ctcttacctg aatacctgca aaaacccatg gtcttcataa ggtttgaaaa      360

cctaacatct gttacatggc tatccacaaa ctgcccaggt aactgccata gctgggcata      420

caacatcttc cggcatacct acagaaactc acggatacaa ttaacatgga tttcatcttt      480

catgagaaac aggaaggttt cctgtgtgct cagcactgtc tgaacaatct attgcaagga      540

gaatatttta gccctgtgga attagcctca attgcacatc agctagatga agaagagagg      600

atgagaatgg cagaaggagg agtcaccagt gaagagtatc ttgcattttt acagcagcct      660

tcagaaaaca tggatgatac cggtttcttc tccattcagg taataagcaa tgccttgaag      720

ttctggggtt tagagatcat ccatttcaat aatcctgaat atcagaagct cggcattgat      780

cctataaatg aaagatcttt tatatgtaat tataaacaac actggtttac tattagaaaa      840

tttggaaaac actggtttaa cttgaattct ctcttggcgg gtccagaatt aatatcagat      900

acatgccttg caaatttctt ggctcgatta caacaacaag catattctgt atttgttgtc      960

aagggtgatc tgccagactg tgaagctgac caactcctgc agatcatcag tgtcgaagag     1020

atggatacac caaaacttaa tggaaaaaaa ttagtaaaac aaaaagagca tagagtctat     1080

aaaacagtcc ttgaaaaagt atcagaagaa agtgatgagt ctggaacatc agaccaagat     1140

gaggaggatt ttcagagggc ccttgaacta agccgccaag aaaccaatag agaagatgaa     1200

catctccgca gtactattga gttaagcatg caaggtagtt ccggaaacac atcgcaagat     1260

cttccaaaga catcatgtgt aactcctgct tcagaacagc cgaagaaaat aaaagaagac     1320

tattttgaaa agcatcagca ggaacagaag cagcagcaac aacagtcaga tctgccgggc     1380

cacagttcat acctacacga aaggccaaca acaagttcga gagcaattga gagtgatctc     1440

agtgatgaca tcagtgaagg cacagtacag gccgctgtcg acaccatttt agaaattatg     1500

agaaagaatt tgaaaatcaa aggggaaaaa taatgccttt aaaaataatt tagatagtca     1560

tactttccaa cattatcctg tgtgattata ctgtaggatc cattttggtc atctgtcaaa     1620

gagatgagga aataaggctt ttagacagtt tgcaaacaaa atgacgagag agatgtggga     1680

ctaaataatg atcgttcaac tactagccaa ggagacattc agcaattaat taaatttaaa     1740

ttagctttc                                                             1749


<210> 2121
<211> 5910
<212> DNA
<213> Homo sapiens

<400> 2121
atggcggccc ggagcgcccc gagctgccac ctgcggctcg agtgggtgta cggctaccgg       60

ggccaccagt gccgcaacaa cctctactac actgcggcca aggagatcgt atacttcgtg      120

gcgggggtcg gcgtggtgta cagcccgcgg gagcacaggc agaagttcta ccggggccac      180

agcgacgaca tcatcagcct tgcattgcat cctgaacgag tgttggtagc aacaggacaa      240

gttgggaaag agccttatat ttgtatttgg gattcataca ctgtgcagac catatcagtt      300

ttaaaggatg ttcatacaca tggtatagct tgcttggcgt ttgacttaga tggacagcgc      360

ttggtttcag ttggacttga ttcaaagaat gcagtttgtg tttgggactg gaaaagggga      420

aaaatgttgt ctatggctcc tggtcataca gatagaatat ttgatatttc ttgggatttg      480

taccagccaa ataaacttgt cagctgtggt gtaaaacata tcaagttctg gagtttatgt      540

ggaaatgctc tgaccccaaa acgaggtgtc tttggtaaga cgggtgacct tcagacaata      600

ctgtgcctag cctgtgcaag ggatgaatta acatattctg gtgcactcaa tggggatata      660

tatgtttgga aaggaatcaa tcttatacga acaatacaag gagcccatgc tgcaggaatt      720

tttagcatga atgcttgtga agaaggcttt gctactggtg gcagagatgg ttgtattcgt      780

ctttgggatt taacttttaa accaattact gtgattgatc tcagggaaac agaccaggga      840

tacaaaggtt tgtctgtaag gagtgtgtgt tggcgaggtg accacattct agttggaaca      900

caggacagtg aaatttttga aattgtggtg caagaaagaa ataaaccttt tctaattatg      960

caagggcatt gtgaaggtga actttgggca cttgctgtcc atcctactaa acctttggct     1020

gtgactggaa gtgatgatcg ttcggtcagg atatggagcc tagtagatca tgcattaata     1080

gcaaggtgta atatggaaga accaattcgt tgtgcagctg tcaatgcaga tggaatccat     1140

cttgcccttg gaatgaagga tggctcattc actgtactta gagtaagaga tatgacggaa     1200

gttgtacata ttaaagatag gaaggaggca attcatgagt taaaatattc accagatgga     1260

acttaccttg ctgttggatg caatgacagc tcggttgata tttatggagt tgctcagcgt     1320

tataaaaaag ttggcgagtg tttgggatcc cttagtttca tcactcatct ggactggtct     1380

tcagacagta gatatttgca gacaaatgat ggaaatggga aaagactttt ttatagaatg     1440

ccaggaggaa aggaagtgac aagtacagaa gaaataaaag gtgttcattg ggcttcatgg     1500

acatgtgttt caggccttga agtaaatgga atttggccca agtattcaga tatcaacgat     1560

ataaattcag tagatggaaa ttatattggc caagttttag ttacagctga tgactatgga     1620

attataaaat tattccgata tccatgttta agaaaagggg ccaagtttag aaaatatatt     1680

ggccattcag ctcacgtaac taatgtcaga tggtcacatg attatcagtg ggttatttct     1740

attggtggag cagatcactc tgtctttcag tggaaattta ttcctgaaag aaaactgaaa     1800

gatgctgttc acatagcacc ccaagaaagt ctggctgact ctcatagtga tgaatcagat     1860

tcagatctgt ctgatgttcc agaactggat tctgaaattg aacaagagac acagctcacc     1920

taccgtcgac aggtttacaa agaagatcta cctcagctta aagaacagtg caaagagaaa     1980

caaaaaagtg ctacttctaa aagaagagag cgggctccag gaaatagtat tcgattacac     2040

tttgttcacg gttacagagg ttatgactgt cgaagtaatc tgttttatac tcaaattggt     2100

gaaattgtgt accatgtggc agcagtgggt gtcatttata atcgacagca aaacacacag     2160

cgtttttatc tgggtcatga tgatgatatt ctctgcctaa ctattcatcc tttgaaagac     2220

tacgtggcaa caggccaggt tggtagagat ccctcaattc atatatggga tacagagacc     2280

attaaaccat tgtccatatt aaagggccac caccagtatg gtgttagtgc cgttgatttc     2340

tcagcggatg ggaaacgttt ggcatcagtt ggcatagatg atagccatac tgttgtgctc     2400

tgggactgga agaaaggaga gaaactttca atagcaagag gaagtaaaga taagattttt     2460

gttgtaaaga tgaaccccta tgtgcctgat aaactaatta cagctggaat taaacacatg     2520

aaattttggc gtaaagcagg gggaggattg attggaagaa aaggctacat aggcacactg     2580

gggaaaaatg acacaatgat gtgtgcagtg tatggatgga ctgaagagat ggctttttct     2640

ggaacatcca caggagatgt gtgtatctgg agagacatct ttcttgtaaa aacagtgaaa     2700

gcgcatgatg ggccagtgtt cagtatgcat gcattggaaa aagggtttgt aactggagga     2760

aaagatggta tagtagctct ttgggatgac tcttttgaaa gatgtctcaa gacctatgct     2820

ataaaaagag ctgcattggc cccaggatct aaaggtcttc tcttggaaga taatccatct     2880

atacgtgcca tatcattagg acatggtcat attttagttg gcacaaagaa tggtgaaata     2940

ctagaagtgg ataaaagtgg cccaataaca cttctggttc agggacacat ggaaggagag     3000

gtgtggggtt tagctacaca cccttatctg cccatctgtg ctactgtaag cgatgataaa     3060

accttaagaa tatgggatct ctcacctagt cattgtatgt tggctgtccg gaagctgaaa     3120

aagggtggga ggtgttgctg tttttctcct gatggtaaag ctttagccgt aggtctcaac     3180

gatggaagct tcttaatggc aaatgcggat actctagagg atcttgtgtc ttttcatcac     3240

agaaaagata tgatttcaga tattcgattt tcacctggtt ctgggaaata tcttgctgta     3300

gcatcccatg acagctttat agatatatac aatgtaatga gtagtaaacg agtaggaata     3360

tgcaaaggag ctaccagtta cataacccat attgattggg atattagagg aaagctttta     3420

caggtcaaca ctggtgctaa ggaacaatta ttctttgaag ctcccagagg gaaaaaacaa     3480

accatcccca gcgtggaggt agaaaaaatt gcttgggcat catggacaag tgtacttggt     3540

ttatgctgtg aaggaatttg gccagtaatt ggagaagtta cagatgtaac tgcttcttgc     3600

ctcaccagtg acaaaatggt tctagctacc ggggacgatt tgggatttgt gaagttattt     3660

agatatccta ctaaagggaa atttggaaag tttaagaggt atgtggccca tagtacacat     3720

gtcacaaatg ttcgctggac ttatgatgac agcatgttgg ttaccctagg cggtacagat     3780

atgtctttaa tggtgtggac aaatgagatg gaaggctatc gagaaaaaag gccttgtgat     3840

agtgaagaat ccgacattga ttctgaagaa gatgggggct atgacagtga tgttacaagg     3900

gagaatgaaa tcagttacac catcagagcc ttatcaacaa atattcgccc aatgttagga     3960

atcaagcctc atttacaaca aaaagaaccc tcaattgatg aaaggcctcc agtgagcagg     4020

gccccaccac agccagagaa actccagaca aacaatgtag gcaagaaaaa gagacctata     4080

gaggaccttg tgttggagct catttttggt tatcgaggca gagactgtag gaataatgtt     4140

cactatttaa atgatggtga tgatataatt tatcacactg catctgttgg aattctgcac     4200

aatgttgcta caggttctca gagtttttat caggaacata atgatgatat tctgtgcctc     4260

acagtaaacc agcaccccaa atttatcaac atagtggcaa ctggccaagt aggtgattca     4320

gcagacatgt cagctacagc tccttctatt cacatctggg atgcaatgaa caagcagact     4380

ttatctatcc taagatgcta ccattcaaag ggagtatgtt cagtcagctt cagtgctact     4440

ggcaaactat tgctgtctgt gggactagac ccagaacata ctattaccat ttggagatgg     4500

caggaaggtg ccaaaattgc cagcagagct ggtcacaatc aacgtatttt tgtggcagaa     4560

ttccgaccag attcagatac ccagtttgtc tcagtgggag taaaacatgt gaagttctgg     4620

accctggcag gaagagctct tcttagcaaa aaagggctac tgagcacact ggaagatgcc     4680

cggatgcaga ccatgctcgc tattgcattt ggtgcaaata acttgacgtt tacaggtacc     4740

atcagtggtg atgtctgtgt gtggaaagat cacatattgt gtagaatcgt ggcgagagct     4800

cacaacgggc ctgtgtttgc catgtacacc accctgcgag atggacttat cgtgactggg     4860

ggaaaggaaa ggccgtcaaa agaaggagga gcggttaaac tgtgggatca ggaactgagg     4920

cggtgccgtg ccttcaggct tgagacagga caagccacag attgtgttcg ttctgtgtgc     4980

agaggcaaag gcaagatcct tgttgggaca aggaatgctg aaataatcga agttggagag     5040

aaaaatgcag cttgtaatat tttagttaac ggtcatgtgg atgggccaat ctggggacta     5100

gcaacacatc cttccaggga ttttttcctt tctgctgcag aagatgggac agtgagactt     5160

tgggatattg ctgataaaaa gatgttaaac aaagtgaatt tgggacatgc tgctcgtact     5220

gtgtgttaca gccctgaagg ggacatggtg gctattggaa tgaaaaatgg agaatttatc     5280

attttactag tgagttctct aaaaatatgg ggaaagaaga gagacaggag atgtgcaatc     5340

catgatatca gatttagtcc ggattcccgg tatctggcag taggttctag tgagaactca     5400

gtggattttt atgacctaac gctgggcccc actcttaaca gaatcagcta ctgcaaagac     5460

attccaagct ttgtcattca aatggacttc tctgcagata gcagttatct ccaggtctct     5520

agtggctgct ataaacggca tgtctatgaa gtgccttcag gaaaacatct tatggatcat     5580

gccgctattg acagaattac ttgggctaca tggactagta ttctaggaga tgaggttttg     5640

ggaatctggt ccagacatgc tgagaaagct gatgtcaact gtgcctgtgt atctcattca     5700

ggaatcagtc ttgttacagg agatgacttt ggcatggtta agttatttga cttcccatgt     5760

ccagaaaaat ttgcaaaaca caaaaggttc ttgggtcatt cgccccatgt gacaaatatt     5820

cgatttacca gtggtgatcg acatgttgtt agtgctggag gtgatgactg cagcttattt     5880

gtctggaaat gtgtacatac acctcactga                                      5910


<210> 2122
<211> 1789
<212> DNA
<213> Homo sapiens

<400> 2122
tcctctccta ttatgcaaac ccacaccatg gatccagcag actactctgg ccccagcatg       60

ctgctccttg ggatgatggg agaaggggga aacctgtgtt ttctcttggt tttagggtat      120

gggtctactt ctttgaacat tcgctcagat cgtaaggtaa ccccaagaat cggcatcact      180

ctctggtctg ggcgcctgga tagtcacgca tggagtccgc gaggtgctgg cgccggagca      240

cgctgggaac gccgggctcc cggccggcct gacccggaag ggctggcgca tggtaacccc      300

agcttcccta gcaaccaagc aggcgcaaga agcaaccagc cgcgctatcc gctcccgttg      360

ctaccggaat gcctcttcag gttagcgatt acagctggca gcagacgaag actgcggtct      420

ttctgtctct gcccctcaaa ggcgtgtgcg tcagagacac ggacgtgttc tgcacggaaa      480

actatctgaa ggtcaacttt cctccatttt tatttgaggc atttctttat gctcccatag      540

acgatgagag cagcaaagca aagattggga atgacaccat tgtcttcacc ttgtataaaa      600

aagaagcggc catgtgggag accctttctg tgacgggtgt tgacaaagag atgatgcaaa      660

gaattagaga aaaatctatt ttacaagcac aagagagagc aaaagaagct acagaagcaa      720

aagctgcagc aaagcgggaa gatcaaaaat acgcactaag tgtcatgatg aagattgaag      780

aagaagagag gaaaaaaata gaagatatga aagaaaatga acggataaaa gccactaaag      840

cattggaagc ctggaaagaa tatcaaagaa aagctgagga gcaaaaaaaa attcagagag      900

aagagaaatt atgtcaaaaa gaaaagcaaa ttaaagaaga aagaaaaaaa ataaaatata      960

agagtcttac tagaaatttg gcatctagaa atcttgctcc aaaagggaga aattcagaaa     1020

atatatttac tgagaagtta aaggaagaca gtattcctgc tcctcgctct gttggcagta     1080

ttaaaatcaa ctttacccct cgagtattcc caacagctct tcgtgaatca caagtagcag     1140

aagaggagga gtggctacac aaacaagctg aggcacgaag agcaatgaat actgacatag     1200

ctgaactttg cgatttaaaa gaagaagaaa agaacccaga atggttgaag gataaaggaa     1260

acaaattgtt tgcaacggaa aactatttgg cagctatcaa tgcatataat ttagccataa     1320

gactaaataa taagatgcca ctattgtatt tgaaccgggc tgcttgccac ctaaaactaa     1380

aaaacttaca caaggctatt gaagattctt ctaaggaatt ctgttctctt gagggcattg     1440

aatgtcaggc ctctgagccc aagctaagcc atcatatccc tagtgacctg cacgtataca     1500

tccagatggc ctgaagcaag tgaagaatca caaaagaagt gaaaatggcc ggttcctgcc     1560

ttaactgatg acattacctt gtgaaattcc ttctcctggc tcagaacctc ccccactgag     1620

caccttgtga cccctgcccc tgcccgccac agaataaccc cctttgactg taattttcca     1680

ttacctaccc aaatcctata aaacggcccc acccctatct cccttcgctg actgtctttt     1740

cggactcagc ccgcctccac ccaggtgatt aaaaagcttt attgctcac                 1789


<210> 2123
<211> 3940
<212> DNA
<213> Homo sapiens

<400> 2123
aggtgacgtc actggccagg ccagccggcg ccattttgaa agtggagtcg cctgcccctg       60

ccgctgccgc cgccgccgtc gctgtcgtag tcgccgccgc cgctgccgga gaaagagcac      120

gagcggggaa gccccagagt gaaatctagc atcctgccgg ctggtctgcc cgcccctcct      180

tccttttccc cccggccccc gtcccctccc cccgcaggtg ccatccgccg ccatccgccc      240

tctctacccc cccatcccca ggtgaggggg gtgagttcag gaagcggaga ccccgaggaa      300

cccagcaggg tcaccatttg cagcgcaaca tggcaggagc tggaggaggg aatgatattc      360

agtggtgttt ttctcaggtg aaaggagcag tagatgatga tgtagcagaa gcagatataa      420

tttctacagt agaatttaat cattctggag aattactagc aacaggagat aaaggtggta      480

gagttgtcat ctttcaacag gagcaggaga acaaaatcca gtctcatagc agaggagaat      540

ataatgttta cagcaccttc cagagccatg aaccagagtt tgactacttg aaaagtttag      600

aaatagaaga aaagatcaac aaaattaggt ggttacccca gaaaaatgct gctcagtttt      660

tattgtctac caatgataaa acaataaaat tatggaaaat cagtgaaagg gacaaaagac      720

cagaagggta taacttgaaa gaggaggatg gaaggtatag agatcctact acagttacta      780

cactacgagt gccagtcttt aggcctatgg atctaatggt tgaggccagt ccacgaagaa      840

tatttgccaa tgctcataca tatcacatca actcaatttc tattaatagt gattatgaaa      900

catatttatc tgcagatgat ttgcggatta atctttggca tctggaaatt acagacagga      960

gttttaacat tgtggatatc aagcctgcca atatggaaga gctaacagag gtgattacag     1020

cagcagaatt tcatccaaac agctgtaaca catttgtata cagcagcagt aaaggaacta     1080

ttcggctatg tgacatgagg gcatctgccc tctgtgatag acattctaaa ttgtttgaag     1140

aacctgaaga tcccagtaac aggtcatttt tttccgaaat catctcctct atttcggatg     1200

taaaattcag ccatagtggt cgatatatga tgactagaga ctatttgtca gtcaaaattt     1260

gggacttaaa tatggaaaac aggcctgtgg aaacatacca ggtgcatgaa tacctcagaa     1320

gtaaactctg ttcactgtat gaaaatgact gcatatttga caaatttgaa tgttgttgga     1380

atggatctga cagtgttgtc atgactggat cttacaataa tttcttcaga atgtttgaca     1440

gaaacacaaa gcgagacata accctagaag catcgcggga aaacaataag cctcgcacag     1500

ttctgaagcc tcgcaaagtc tgtgcaagtg gcaagcgaaa gaaagatgaa ataagtgttg     1560

acagcctaga cttcaataag aaaatccttc acacagcctg gcaccccaag gaaaatatca     1620

ttgccgtagc tactacaaac aatctgtata tatttcaaga caaagtgaat tagggttggc     1680

attcctagca gaagaaccca cttcctgctt agttgagata gttgaatcta gcattcgttc     1740

ctataaaaga gagaggtcca ttgtggcgcc cctttccagt gtttgacagt gtgccattcg     1800

acaacacatt gttatagcta catggagaaa gctctgtgga ttcatcactg tggtgttctc     1860

catgtctgct agccatttag gtaagggtag ggcactttta atttaaatga cttcttgcac     1920

catcttgcct aatggactag attggactgt atcaacattg atttactcca ctttttatgc     1980

cttccattgt gatgacgtca aacacagtga aagccttcag tcatgctatg ggatttaatt     2040

gtgtatcctc attactgtat catttgtggg gtacacccct tccccctttt tttaaattaa     2100

atacagctca ttcttactgt ggcttgtagc attcctcctc ttctggcctc ctggactgct     2160

ccccttcatc tcttaccctt gccccctcca cccggtcttg gtggtggtat attaaaaaaa     2220

gaaagaatga aagcacacaa aatgagtcag tttggggtca gtggtataaa gggggtatat     2280

gttgcaaaca aatgttttag taacagttgg ctgtaatcac tcctcgccgt gtctggcact     2340

gaaaataagg aaaaaaaacc tactactgaa taaaagtgac aaagaatgga gaatctggtt     2400

ttctttttct ttttaaccta cctcttgtag ccaatatttt gtgtcatacc tttgggcaca     2460

gtgaaacaaa atgggttttc attgtttatt ggtatttttg ttaattattt ttaacaagtg     2520

ttcttttaca tgcaggagga gaggtattgg ttctctatga acatattttg aatataggtt     2580

ttattaagga tttcacaatc tataaatgct actagttttt tttttttttt ttaccatcat     2640

gagggtattg gatacattgt gtctctattt aactcattat gtgttaatga aattgttgta     2700

aatgggaacc aaatttgtag aacttaattt ctacttttta gagtgcttaa tttcattttt     2760

gccttactaa atagtcaaag acttataaaa catttttaac aagttagaac ttttttgtta     2820

ttcagtcata taaaatagca gaaaactaac atcaagtgac actgcactaa atactttttt     2880

tgtattttac tgctatcaaa tcagaatgaa atatacttta ccatagatat ttttcttcta     2940

tttttggttt tccaaagcta tatgaaagac aaatttttaa aggtacagcg ttcaaaaagt     3000

gcttaatgaa ctccaacagc tgcctcaaat aaaaatctgt atatgaatac attttcccta     3060

agcggtgata cattatccaa agatgaagag tgctcctatt tttaataggt agaatgtacc     3120

tttgtcagtc ttgcagaaac tttaatggag aagaaatgga ctttattttt gaaaggtgaa     3180

atgaacaggc atttatatta ttagagaatg gtagtcttat tttggtggaa cataatgtaa     3240

caaccttgaa tttcagagga ctctgagtgc ttctatgtcc actacctatt gttctattct     3300

tcaataatga aaaagaattc aacgagccga ccgtgattcc ctctactaca aatattatgt     3360

cttgtaagtt agcattttta gcacacagga gaaattttat gtaataaaat tactgtatct     3420

tttggattta acaaatttgt atttgaaaca cattctatgt ctgataattc ttaatggcac     3480

ttttactaat ttatttgggg atcttgggta cattcttaat ttgtgtttat tcttcacgct     3540

tgacttgcaa gtgggatatt cccctgccac aagtgtcaaa cagtgatatt cttcctgtgt     3600

tgtgactgga cagttttcca gatctttttt gggagatttt cctacagctt ggttgtatgt     3660

cttgagataa caccaccaaa cagctctcag aaattctttt ttgattgatc agtagctatg     3720

atgattctcc tccatgacac taaggattag tttatatatt taagagaaat aattgctaaa     3780

attaaaatgc ctctatcaag gaatgctatt ataaattatt gttaacattc tcaagtatta     3840

attttttaat ttcattggtg tagcaaactc taagcccagc cactcatttt acatggccat     3900

ggttaatctt tttattaata aaaattatac ttagaataaa                           3940


<210> 2124
<211> 4537
<212> DNA
<213> Homo sapiens

<400> 2124
gcggcgcgca cggtatggcg gcggcggcgg cggcggcggc gcgcgcctga gaagagggga       60

cgccagcccg gtcaggcctc ggcgcggcct acacgctccg ctcgctcgct cgctcccgcc      120

tcccgccccg cgcccggcca tggcggagcc gtcgtccgcc cgacgcccgg tgcctctcat      180

cgagtcggag ctgtacttcc ttatcgcccg gtacctatcg gcgggcccgt gtcggagagc      240

ggcccaggtg ctggtgcagg agctggagca gtaccagttg ttgccgaaga gattggactg      300

ggagggcaac gagcacaaca ggagctacga ggagttggtc ttgtccaata agcatgtggc      360

tcctgatcat cttttgcaaa tctgccagcg catcggtcct atgttggata aagaaattcc      420

acccagtatt tcaagagtca cttctttact tggtgcagga aggcagtctt tgctacgtac      480

agcaaaagac tgcaggcaca cagtttggaa gggctctgcc tttgctgctc ttcatagagg      540

aagacctcct gaaatgccag tgaattatgg ttccccacca aatcttgtgg agatacatcg      600

aggaaaacaa ctcacagggt gttccacttt tagtacagca tttccaggaa ctatgtatca      660

gcatataaaa atgcacagaa ggattctcgg acatctatct gctgtttact gtgtagcatt      720

tgataggaca ggacatagaa tctttacagg ttcagatgac tgtttggtaa agatttggtc      780

aacacataat ggccgcttgt tatctacatt aagaggtcat tctgcagaaa tttcagatat      840

ggcagtaaac tatgagaata caatgattgc tgcggggagc tgtgataaaa ttattagagt      900

gtggtgcttg agaacttgtg ccccagttgc tgtgctccaa ggacacacag gatcaattac      960

atctttacag tttagcccga tggccaaagg ctctcaaaga tacatggttt ccactggtgc     1020

tgatgggaca gtttgctttt ggcaatggga tttagaatcc ttaaaattta gcccacgtcc     1080

cctgaagttc actgaaaagc ctaggccagg cgttcaaatg ctttgttctt cttttagtgt     1140

tggtggtatg tttttagcca caggtagtac tgatcatgta atcagaatgt attttttggg     1200

ttttgaagca cccgaaaaaa tcgcagaact tgaaagccac actgataaag tagatagtat     1260

ccaattttgt aacaatggtg atcggttcct aagtggtagc agagatggaa cagcacggat     1320

ttggagattt gagcagttag aatggaggag cattttattg gatatggcta ccagaatctc     1380

aggggactta tcttccgaag aggaaaggtt tatgaaacct aaagtaacaa tgatagcttg     1440

gaatcaaaat gatagcattg ttgtcacagc tgtgaatgat catgtcctca aagtgtggaa     1500

ttcttacact ggacaactgc ttcataactt aatgggacat gctgatgaag tatttgttct     1560

ggagacacat ccctttgatt ccagaattat gttatctgca ggacatgatg gcagcatatt     1620

tatatgggat attacaaaag gtaccaagat gaaacattat tttaatatga ttgaaggaca     1680

aggacatgga gctgtgtttg actgtaagtt ttcacaggat ggacagcatt ttgcctgtac     1740

agattctcat gggcaccttc tgatatttgg ttttggatgc agcaaaccat atgaaaagat     1800

tcctgatcag atgttcttcc atactgacta tcgaccactt attagagatt ctaataatta     1860

tgtcttagat gagcaaactc agcaggctcc tcatcttatg cctccaccat tcttggtaga     1920

tgtagatgga aatcctcatc caaccaagta tcagagatta gtaccaggcc gagaaaattc     1980

tgcagatgaa catttgattc cacagctggg ctatgtggca acaagtgatg gagaggtgat     2040

tgaacaaatt ataagcctgc aaaccaatga taatgatgaa cgcagcccag aatcgagtat     2100

tcttgatgga atgataagac agttgcagca gcagcaagat cagagaatgg gagcagatca     2160

ggatactatt ccaagaggac tttcaaatgg tgaagaaaca ccccggagag gttttagaag     2220

gctgagctta gacattcagt cccctccaaa tattggtctg cgtcgtagtg gacaagttga     2280

aggtgttcgt cagatgcatc aaaacgctcc acgcagtcag attgctacag aacgtgacct     2340

gcaggcttgg aaacgaagag tggttgtacc agaggtacca ctaggcatat ttaggaagct     2400

ggaagacttc cgattagaga aaggtgaaga ggaaagaaat ctttatataa taggaagaaa     2460

aagaaagact cttcagctct cacataagtc ggattcagtg gttttggtat cacagtctag     2520

acaaaggaca tgtaggcgta aatatccaaa ttatggtaga agaaatcgta gctggcgtga     2580

gttatcttct ggaaatgagt cttcaagctc tgtaagacat gagacttcct gtgatcagag     2640

tgaaggttct ggttcttcag aagaggatga atggagaagt gacagaaaaa gtgagagtta     2700

cagcgaaagt tcaagtgact cttcatctag atattccgat tggacagctg atgcgggcat     2760

caatttgcag cctcctttaa gaacatcatg tcgtcgacga attactcgat tttgtagtag     2820

ttcagaagat gaaatatcta ctgagaattt atctcctcca aaaagaagac gaaagagaaa     2880

gaaagaaaat aagcctaaga aggagaattt gcggaggatg actccagcag agcttgcaaa     2940

tatggagcat ttatatgaat ttcaccctcc agtttggatt actgacacca cacttagaaa     3000

atctcctttt gttcctcaaa tgggtgatga ggtaatatat tttcgacagg gtcatgaagc     3060

ttatattgag gctgtaagaa gaaataatat ttatgaactg aaccctaata aggagccatg     3120

gagaaaaatg gatcttaggg atcaagaatt ggttaaaata gttggaatac gatatgaagt     3180

tgggccccct acactctgtt gcctaaaact agcatttata gatccagcaa ctggaaaact     3240

tatggacaaa tctttctcta ttagatatca tgatatgcca gatgttattg actttcttgt     3300

attgcgtcaa ttttatgatg aagcaagaca gaggaattgg cagtcttgtg acagattccg     3360

ctctattatt gatgatgctt ggtggtttgg aacagtgtta agtcaagagc catatcaacc     3420

acagtatcct gatagtcatt tccagtgtta tattgttagg tgggataata ctgaaattga     3480

aaaacttagc ccatgggaca tggaaccaat tcctgataat gttgatccac ctgaagaatt     3540

aggagctagt atttctgtca caacagatga gctagagaaa ttgctctata aaccacaagc     3600

tggtgaatgg ggtcagaaat caagagatga agaatgtgat agaattatca gtggtataga     3660

tcaacttttg aatcttgata tagcagcagc ttttgcaggc cctgttgatt tgtgtacata     3720

cccgaagtac tgtactgtag tagcttatcc aaccgatctt tacacaattc gaatgagact     3780

tgttaatcga ttttacagga ggctgtctgc gttagtttgg gaagtcagat atatagaaca     3840

taatgccaga acatttaacg aacctgagag tgtaattgca agatcagcta aaaagataac     3900

tgaccaactt ttaaaattta tcaagaatca acactgtaca aatatctcag aactttctaa     3960

cacatctgaa aatgatgagc aaaatgctga ggatttggat gatagtgatc ttcctaaaac     4020

atcttctgga aggaggagag actacagaga tattatagat accccaatgg attttggaac     4080

agtaagggaa actctagatg cgggaaatta tgacagccct ttggagtttt gcaaagacat     4140

ccggctgata tttagcaatg caaaagcgta tacaccaaac aaaagatcaa agatttatag     4200

tatgaccttg agattatctg ccttatttga agaaaaaatg aagaaaatct cttctgattt     4260

taaaattggt caaaaattca atgaaaaact tcgaagaagc cagaggttca agcaacggca     4320

aaattgtaaa ggtgacagtc agcctaacaa aagtatcaga aacctcaagc cgaagaggtt     4380

aaaatctcag acaaaaataa ttcctgagtt ggtaggttct cctacccagt ctacctcaag     4440

taggacagct tatcttggaa cccacaagac aagtgctggt atctcttcag gtgttacttc     4500

tggtctcttc agattcagca gaatcatcag aaaggag                              4537


<210> 2125
<211> 1034
<212> DNA
<213> Homo sapiens

<400> 2125
attatcctcc ttattgacaa acagagcggt cgcggcggcg actctcggcg tgcggtgata       60

gccaagccat gggagacaag aagagcccca ccaggccgaa gcggcagccg aagccgtcct      120

cggatgaggg ttactgggac tgtagcgtct gcaccttccg gaacagcgcc gaggccttca      180

agtgcatgat gtgcgatgtg cggaagggca cctccacccg agataacagg aagagagcct      240

ggttaccatt tggtggaaca atcctgctgg ctcaagcctc tgcctagaaa tttgggtcat      300

tctctttttt ggacagtctg gaaacctcga cctgtctccc agttggttgc acagcaggtt      360

actcagcagt ttgtgcctcc tacacagtca aagaaagaga aaaaagataa agtagaaaaa      420

gaaaaaagtg aaaaggaaac aactagcaaa aagaatagcc ataagaaaac caggccaaga      480

ttgaaaaatg tggatcggag tagtgctcag catttggaag ttactgttgg agatctgaca      540

gtcattatta cagactttaa ggagaaaaca aagtcaccgc ctgcatctag tgctgcttct      600

gcagatcaac acagtcaaag cggctctagc tctgataaca cagagagagg aatgtccagg      660

tcatcttcac ccagaggaga agcctcatca ttgaatggag aatctcatta aagtttattt      720

tctccaattt cttagtcact tctgtcctac catgcaaata cacagattat gccaagaggt      780

accacatttt catgacagat acattcatgc acaatccata atttgagttt tacataaaat      840

agaaatttgt tagaatttgt tagattttat tgcaatgatg cctaccaaac atttccagac      900

ttaacatttt ggtctctgca gttaagtgcc atgaaaatgt ggttgaatta ttcattatgc      960

agtgttattg gtaagtgtat tttcactttt agtttagtga attctaacac ataattcttg     1020

aattctctac tatt                                                       1034


<210> 2126
<211> 1211
<212> DNA
<213> Homo sapiens

<400> 2126
ccctccctcc ctcctccccc gcccgcttcc gcccggctta ttatcctcct tattgacaaa       60

cagagcggtc gcggcggcga ctctcggcgt gcggtgatag ccaagccatg ggagacaaga      120

agagccccac caggaaacct cgacctgtct cccagttggt tgcacagcag gttactcagc      180

agtttgtgcc tcctacacag tcaaagaaag agaaaaaaga taaagtagaa aaagaaaaaa      240

gtgaaaagga aacaactagc aaaaagaata gccataagaa aaccaggcca agattgaaaa      300

atgtggatcg gagtagtgct cagcatttgg aagttactgt tggagatctg acagtcatta      360

ttacagactt taaggagaaa acaaagtcac cgcctgcatc tagtgctgct tctgcagatc      420

aacacagtca aagcggctct agctctgata acacagagag aggaatgtcc aggtcatctt      480

cacccagagg agaagcctca tcattgaatg gagaatctca ttaaagttta ttttctccaa      540

tttcttagtc acttctgtcc taccatgcaa atacacagat tatgccaaga ggtaccacat      600

tttcatgaca gatacattca tgcacaatcc ataatttgag ttttacataa aatagaaatt      660

tgttagaatt tgttagattt tattgcaatg atgcctacca aacatttcca gacttaacat      720

tttggtctct gcagttaagt gccatgaaaa tgtggttgaa ttattcatta tgcagtgtta      780

ttggtaagtg tattttcact tttagtttag tgaattctaa cacataattc ttgaattctc      840

tactattggc atgtaacgaa tttaaatttt ttataacata gtgcaagctg cctaaatatg      900

tattatttga gaattgtgaa acagatagtt atatgtatac aagtcaaaga acaacttaac      960

tattgctgca acaggttttt cttaatggtt atcctcttaa atacacctgc tggtacttgg     1020

tgtggttaaa taggaaaatt gttattaaat aaagaatttg tatgaacctt tgccaatgtt     1080

tttgacacgt tttactaatt attgttcctg aattatgttt ctggttttat ctattttttg     1140

aggttttttt gtttgcttat ttttcaaaac attcatttat tgtaatgttt actagcggac     1200

tagtaaacaa t                                                          1211


<210> 2127
<211> 1793
<212> DNA
<213> Homo sapiens

<400> 2127
agatctgatc gctgctgccc tgctctcctc ctcctctcat tcctctgcct cctggattcc       60

tgaagtttag gagaaataag gtagccaagg gaaccacatg gaagttgtga cagctcccag      120

cggcgcgccc ctttcgtgtg tgccggtacc tcggcttagg agttgcccgc tgacaccttg      180

aatgaaggag gtccccttgc cagccagcct gccgggatgg gccattgctg ctgcaagcct      240

tataactgcc ttcagtgcct ggacaagacg aatgaaagtg cccttgtgaa agaaaaagag      300

ctgtcaatcg aacttgcaaa catcagggat gaagttgcct tccatacagc aaagtgcgag      360

aaactacaaa aggagaagga ggagctggag aggcggttcg aggacgaggt gaagaggctg      420

ggctggcagc agcaggccga gctccaggag ctggaggagc ggctgcagct gcaattcgag      480

gcggaaatgg cgcgcctgca ggaggagcac ggtgaccagc tgctgagcat ccggtgtcaa      540

caccaggagc aggtggaaga tctcaccgcc agccatgatg ctgctctcct agagatggaa      600

aataaccaca cagttgccat cacaatcctg caggatgacc acgaccacaa agtccaagaa      660

ttgatgtcca ctcatgagct tgaaaagaaa gaattggaag aaaattttga aaaactgcgg      720

ctgtcattgc aggaccaggt ggacacgctg accttccaga gccagtctct gcgggacaga      780

gcccgccgct tcgaagaggc cttgaggaag aacacagagg agcagctgga gattgcattg      840

gctccttatc agcacttgga agaagacatg aagagtctga agcaggtatt agaaatgaag      900

aatcagcaaa tacacgagca agaaaagaag attcttgagc tggaaaagct ggcagaaaag      960

aacattatcc tagaagaaaa gatccaggtt ctccaacagc agaacgaaga cctcaaagca     1020

aggattgacc aaaacacagt tgtcaccaga cagctgtcgg aggaaaatgc taacctccag     1080

gaatatgttg agaaggaaac ccaggagaag aagagattga gccgaaccaa tgaagagctg     1140

ctttggaagc tccaaactgg ggacccgacc agtccgatta aactctcgcc cacatctccc     1200

gtttaccgcg gctcctcctc ggggccctcc tctccggcca gagtcagcac aacacccaga     1260

tgacgccact acacggcctg cgggagctcc ggcttctcgt cctccggtct ccaccctgag     1320

ggagcaccga cccggtgccg ccggagctgg ccctgtgcgc atgctcagta gctgcgaatg     1380

catcctaggc gcgtcctcct ctgatccccg tgtaagactg ccctggtgtc ggcacttagg     1440

aatgtgtaaa tggtaaagtc tgatgtgcaa acgttttacc atagttagag ccaaaagaaa     1500

gacacttgca attgttcttg agcaatgaac tttcactgca gaatttcagg ttagttacaa     1560

aaagctcagt tttcaatata cattgaataa tcattgtgta ctgcaccgat atgtgtgtat     1620

atttagatat acgtatatac acatgctgcg gttctgaatt tcatttttta taacatgaag     1680

tgctgacata ttttagtgaa ggtcagcagt tttctaactt gtgcctaaga attattggga     1740

aatgaaaatg catttctatc tagcttccca ggaatatttc tacccaaaat aga            1793


<210> 2128
<211> 2833
<212> DNA
<213> Homo sapiens

<400> 2128
ctccccgggc ggctccggct cccgcagcgg gacagaccca cccgcccagg cttttatccg       60

gcaccggcag cgtcttcctt tcctcccccg tctatggtgg tggcggcggc ggctcctcgg      120

gcggcggcgg aagacgaggc tgcggcgttg ccatgaacag tggcggcggc ctcccgcccc      180

cctcggccgc cgcctcccct tcctcctcct cgctggcggc ggcggtggcg gtggtggccc      240

cgccgggggt cgggggtgtc cccggcgggg cggcggtagg agtgaagctg aagtactgcc      300

gctactacgc taaggataag acttgcttct acggggagga gtgtcagttc ctgcatgagg      360

accctgccgc cggggctgcc ccgggcctcg gcctccatag caacagcgtc cccctggctc      420

tggctggtgc acccgtggcc ggctttccgc cgggagccgt cgcgggcggg ggagctgggc      480

cgccccccgg gcccaagaag ccggacctgg gggacccggg gaccggagcc gcagccggcg      540

gaggaggcag tagcggggga ctcgatggac cgcggctggc aattccagga atggatggag      600

gtgctttaac tgatacaagt ctcacagatt cctattttag caccagcttt attggagtca      660

atggatttgg aagccctgta gaaacaaaat atcccctgat gcagagaatg actaatagta      720

gcagctcccc aagccttcta aatgacagtg ccaagccata ttcagcccat gatcctctaa      780

catcacctgc ttcatccttg tttaatgact ttggtgccct caacatctct cagagacgaa      840

agccaaggaa gtatcgcctg gggatgctgg aggagaggct agttccgatg ggatcaaagg      900

cacgaaaagc aaagaaccct attggctgcc ttgctgacag gtgtaaatca ggagtaccca      960

tcaatatggt ttggtggaac agagtcacag aaaacaattt acagacacca aatcctactg     1020

caagcgagtt tattcctaaa ggaggatcaa cctccaggct gagtaacgtg tcccagtcaa     1080

atatgtctgc cttctctcaa gttttctctc acccatccat gggaagccct gctactgctg     1140

gattagcgcc aggaatgtcg ttgtctgctg ggtcttcccc tcttcattcc cccaagatta     1200

ctccacatac ttctcctgct cccagaagaa gaagtcacac tccaaatcca gcaagttaca     1260

tggtgccttc tagtgcctct acatctgtta ataatcctgt ttctcagact ccgtcttctg     1320

gtcaggtgat ccaaaaggaa actgttggtg ggacgactta cttctataca gacacaactc     1380

cagcaccttt gactggaatg gtgtttccaa actatcatat ttatcctcca actgcacctc     1440

acgttgctta tatgcaaccg aaagcaaacg caccttcctt cttcatggct gatgaactcc     1500

gacaggagct gatcaacaga catttaataa caatggctca aattgatcaa gcagatatgc     1560

cagcagttcc tacagaggtt gacagctacc atagcctatt ccctctagaa ccactgccac     1620

ctcccaaccg gatacagaaa tcaagtaatt ttggatatat tacatcttgc tacaaagctg     1680

taaacagcaa agatgatctg ccatattgcc ttcggaggat acatggtttt cgtcttgtta     1740

acacaaagtg catggtgttg gtcgacatgt ggaagaaaat tcaacactca aatatcgtaa     1800

ctttgcgtga agtatttacc actaaagcat ttgctgagcc ctctcttgtg tttgcatatg     1860

atttccatgc tggaggagaa actatgatga gcagacactt taatgaccct aatgctgatg     1920

cctacttcac caagagaaag tggggtcagc acgagggacc attgcccagg cagcatgctg     1980

gattattgcc agaatctctt atttgggcat atattgtcca actaagttct gcattgcgta     2040

ccattcatac agcaggtttg gcatgtcgag ttatggatcc aacaaagatt ctgataactg     2100

gcaaaacaag gttgcgagta aattgtgttg gagtttttga tgttttaaca tttgataaca     2160

gtcaaaataa taatccattg gcattaatgg cccagtacca gcaagcagat ctgatatcat     2220

taggaaaagt tgtgttggct ttggcttgca actctttggc aggaattcag cgagagaatt     2280

tacagaaagc catggaactg gtgacaatca actattcctc tgacctgaag aatctgattt     2340

tgtatttgtt gactgaccaa aacaggatgc gaagtgtaaa tgacatcatg cccatgattg     2400

gtgctcgatt ttatactcaa ttggatgctg ctcaaatgag aaatgatgtc atagaggaag     2460

accttgcaaa ggaggttcaa aatggaagac tgtttaggct cctagcaaaa ttgggaacaa     2520

tcaatgagag gccggagttt cagaaggatc ccacttggtc agagactgga gaccgttatc     2580

tgttgaaact ctttagggat catctttttc atcaggtgac agaagcaggt gctccctgga     2640

ttgacctcag tcatataatt tcttgtctta acaagctaga tgctggtgtg ccagaaaaaa     2700

taagcctgat ttccagagat gagaagagtg tacttgtggt gacctacagt gacttaaagc     2760

gctgctttga aaatactttt caagaactga ttgcagctgc aaatggtcag ttgtagtatt     2820

tgctaaaaaa gca                                                        2833


<210> 2129
<211> 1855
<212> DNA
<213> Homo sapiens

<400> 2129
ctgtggcgct tcccctgcga ggatggctac cctggttgta aacaagctcg gagcgggagt       60

agacagtggc cggcagggca gccgggggac agctgtagtg aaggtgctag agtgtggagt      120

ttgtgaagat gtcttttctt tgcaaggaga caaagttccc cgtcttttgc tttgtggcca      180

taccgtctgt catgactgtc tcactcgcct acctcttcat ggaagagcaa tccgttgccc      240

atttgatcga caagtaacag acctaggtga ttcaggtgtc tggggattga aaaaaaattt      300

tgctttattg gagcttttgg aacgactgca gaatgggcct attggtcagt atggagctgc      360

agaagaatcc attgggatat ctggagagag catcattcgt tgtgatgaag atgaagctca      420

ccttgcctct gtatattgca ctgtgtgtgc aactcatttg tgctctgagt gttctcaagt      480

tactcattct acaaagacat tagcaaagca caggcgagtt cctctagctg ataaacctca      540

tgagaaaact atgtgctctc agcaccaggt gcatgccatt gagtttgttt gcttggaaga      600

aggttgtcaa actagcccac tcatgtgctg tgtctgcaaa gaatatggaa aacaccaggg      660

tcacaagcat tcagtattgg aaccagaagc taatcagatc cgagcatcaa ttttagatat      720

ggctcactgc atacggacct tcacagagga aatctcagat tattccagaa aattagttgg      780

aattgtgcag cacattgaag gaggagaaca aatcgtggaa gatggaattg gaatggctca      840

cacagaacat gtaccaggga ctgcagagaa tgcccggtca tgtattcgag cttattttta      900

tgatctacat gaaactctgt gtcgtcaaga agaaatggct ctaagtgttg ttgatgctca      960

tgttcgtgaa aaattgattt ggctcaggca gcaacaagaa gatatgacta ttttgttgtc     1020

agaggtttct gcagcctgcc tccactgtga aaagactttg cagcaggatg attgtagagt     1080

tgtcttggca aaacaggaaa ttacaaggtt actggaaaca ttgcagaaac agcagcagca     1140

gtttacagaa gttgcagatc acattcagtt ggatgccagc atccctgtca cttttacaaa     1200

ggataatcga gttcacattg gaccaaaaat ggaaattcgg gtcgttacgt taggattgga     1260

tggtgctgga aaaactacta tcttgtttaa gttaaaacag gatgaattca tgcagcccat     1320

tccaacaatt ggttttaacg tggaaactgt agaatataaa aatctaaaat tcactatttg     1380

ggatgtaggt ggaaaacaca aattaagacc attgtggaaa cattattacc tcaatactca     1440

agctgttgtg tttgttgtag atagcagtca tagagacaga attagtgaag cacacagcga     1500

acttgcaaag ttgttaacgg aaaaagaact ccgagatgct ctgctcctga tttttgctaa     1560

caaacaggat gttgctggag cactgtcagt agaagaaatc actgaactac tcagtctcca     1620

taaattatgc tgtggccgta gctggtatat tcagggctgt gatgctcgaa gtgtttttca     1680

gataatatgt gaccaatata ctgggaaaga ggtagtcaca gagaaagggt aaaaggtcat     1740

gctgttacag gtgtagtttg tgtgcataaa taatacttcc gaattaaatt atttaatatt     1800

tgactgattt caataactgt gaaaaataaa aaaggtgttg tattgcttgt gagaa          1855


<210> 2130
<211> 3360
<212> DNA
<213> Homo sapiens

<400> 2130
gactacccgg cgtgcgcgtc ctcctgccgg cctgcaggcc cggggcctcc gcctgcttcc       60

ccacagctgc tccttgcggc cccgcttgcg ttcacgctgt cgcccgggcc ggcgcggccg      120

cgggcaaccg ctccccctcc cacacctacc ccgccccctc cccgcctttt ccgccctccg      180

gtccccctcc ctcggcccgc tgctgctgct ccagatgagg tgatggcaac ggccaacttc      240

ggcaagatcc agatcgggat ttacgtggag atcaagcgca gcgatggtaa atacgagttc      300

acagtatacc agcaaaagta ggatttacat attattttga agattctggg tgcacagcaa      360

cacctgtccc tggtatacac ccaagggaga ggaaatcacc accttgtgaa gatatctgca      420

ctctcgcgtt cattgcagca ttattcacag tagccaagat agggaagcaa cctaaatgtc      480

catcgatggg ccgaatacat caagcaatgg taacatcttt aaatgaagat aatgaaagtg      540

taactgttga atggatagaa aatggagata caaaaggcaa agagattgac ctggagagca      600

tcttttcact taaccctgac cttgttcctg atgaagaaat tgaacccagt ccagaaacac      660

ctccacctcc agcatcctca gccaaagtaa acaaaattgt aaagaatcga cggactgtag      720

cttctattaa gaatgaccct ccttcaagag ataatagagt ggttggttca gcacgtgcac      780

ggcccagtca atttcctgaa cagtcttcct ctgcacaaca gaatggtagt gtttcagata      840

tatctccagt tcaagctgca aaaaaggaat ttggaccccc ttcacgtaga aaatctaatt      900

gtgtgaaaga agtagaaaaa ctgcaagaaa aacgagagaa aaggagattg caacagcaag      960

aacttagaga aaaaagagcc caggacgttg atgctacaaa cccaaattat gaaattatgt     1020

gtatgatcag agactttaga ggaagtttgg attatagacc attaacaaca gcagatccta     1080

ttgatgaaca taggatatgt gtgtgtgtaa gaaaacgacc actcaataaa aaagaaactc     1140

aaatgaaaga tcttgatgta atcacaattc ctagtaaaga tgttgtgatg gtacatgaac     1200

caaaacaaaa agtagattta acaaggtacc tagaaaacca aacatttcgt tttgattatg     1260

cctttgatga ctcagctcct aatgaaatgg tttacaggtt tactgctaga ccactagtgg     1320

aaactatatt tgaaagggga atggctacat gctttgctta tgggcagact ggaagtggaa     1380

aaactcatac tatgggtggt gacttttcag gaaagaacca agattgttct aaaggaattt     1440

atgcattagc agctcgagat gtctttttaa tgctaaagaa gccaaactat aagaagctag     1500

aacttcaagt atatgcaacc ttctttgaaa tttatagtgg aaaggtgttt gacttgctaa     1560

acaggaaaac aaaattaaga gttctagaag atggaaaaca gcaggttcaa gtggtgggat     1620

tacaggaacg ggaggtcaaa tgtgttgaag atgtactgaa actcattgac ataggcaaca     1680

gttgcagaac atccggtcaa acatctgcaa atgcacattc atctcggagc catgcagtgt     1740

ttcagattat tcttagaagg aaaggaaaac tacatggcaa attttctctc attgatttgg     1800

ctggaaatga aagaggagct gatacttcca gtgcggacag gcaaactagg cttgaaggtg     1860

ctgaaattaa taaaagcctt ttagcactca aggagtgcat cagagcctta ggtagaaata     1920

aacctcatac tcctttccgt gcaagtaaac tcactcaggt gttaagagat tctttcatag     1980

gtgaaaactc tcgtacctgc atgattgcca caatctctcc aggaatggca tcctgtgaaa     2040

atactcttaa tacattaaga tatgcaaata gggtcaaaga attgactgta gatccaactg     2100

ctgctggtga tgttcgtcca ataatgcacc atccaccaaa ccagattgat gacttagaga     2160

cacagtgggg tgtggggagt tcccctcaga gagatgatct aaaacttctt tgtgaacaaa     2220

atgaagaaga agtctctcca cagttgttta ctttccacga agctgtttca caaatggtag     2280

aaatggaaga acaagttgta gaagatcaca gggcagtgtt ccaggaatct attcggtggt     2340

tagaagatga aaaggccctc ttagagatga ctgaagaagt agattatgat gtcgattcat     2400

atgctacaca acttgaagct attcttgagc aaaaaataga cattttaact gaactgcggg     2460

ataaagtgaa atctttccgt gcagctctac aagaggagga acaagccagc aagcaaatca     2520

acccgaagag accccgtgcc ctttaaaccg gcatttgctg ctaaaggata cccagaaccc     2580

tcactactgt aacatacaac ggttcagctg taagggccat ttgaaagttt ggaattttaa     2640

gtgtctgtgg aaaatgtttt gtccttcacc tgaattacat ttcaattttg tgaaacactc     2700

ttttgtctac aaaatgcttc tagtccagga ggcacaacca agaactggga ttaatgaagc     2760

attttgtttc atttacacaa atagtgattt acttttggag atccttgtca gttttatttt     2820

ctatttgatg aagtaagact gtggactcaa tccagagcca gatagtaggg ggaagccaca     2880

gcatttcctt ttaactcagt tcaatttttg tagtgagact gagcagtttt aaatcctttg     2940

cgtgcatgca tacctcatca gtgattgtac ataccttgcc cactcctaga gacagctgtg     3000

ctcacctttt cctgctttgt gccttgatta aggctactga ccctaaattt ctgaagcaca     3060

gccaagaaaa attacattcc ttgtcattgt aaattacctt tgtgtgtaca tttttactgt     3120

atttgagaca ttttttgtgt gtgactagtt aattttgcag gatgtgccat atcattgaac     3180

ggaactaaag tctgtgacag tggatatagc tgctggacca ttccatctta tatgtaaaga     3240

aatctggaat tattatttta aaaccatata acatgtgatt ataatttttc ttagcatttt     3300

ctttgtaaag aactacaata taaactagtt ggtgtataat aaaaagtaat gaaattctga     3360


<210> 2131
<211> 2505
<212> DNA
<213> Homo sapiens

<400> 2131
ctcgccgaga tgacctgggc acctctgcgt tgaatcggca aatactgatc aagccgcatt       60

tattctgctc tcaggaactc taagtctagc agagaagatg aggcggtaga agttcatcaa      120

tggcttggct ggaggacaag caaattgagg acattggcaa cggagtgatc aaaatgatag      180

atcatgaggc ctaaaatgaa taaggaaaga agagaagtgg cagaggctga gaacagaaag      240

agagggtgga ggggctgtaa atcttgaaga ttagggtata atatgagtat atgggtaaga      300

attggaagaa ttgtgtagga ggcagtagtc aaaaagtaga agcagtttgg aagagtagtt      360

acaaatatca agagccaggt ggctaaaagg tggagctata ggtcattgaa gctcaagaaa      420

ctgagtctct agggcattgg ttaagtcatc tgtctagact tcaaagttgt ctaggatgat      480

aattcagaag actgatctgt gccaaagtca caggtttttc acgactgaaa acaacatagc      540

aaaataagcc aagatgtctg tggatccaat gacctacgag gcccagttct ttggcttcac      600

gccacaaacg tgcatgcttc ggatctacat tgcatttcaa gactacctat ttgaagtgat      660

gcaggccgtt gaacaggtta ttctgaagaa gctggatggc atcccagact gtgacattag      720

cccagtgcag attcgcaaat gcacagagaa gtttctttgc ttcatgaaag gacattttga      780

taaccttttt agcaaaatgg agcaactgtt tttgcagctg attttacgta ttccctcaaa      840

catcttgctt cctgaagata aatgtaagga gacaccttat agtgaggaag attttcagca      900

tctccagaaa gaaattgaac agttacagga gaagtacaag actgaattat gtactaagca      960

ggcccttctt gcagaattag aagagcaaaa aattgttcag gccaaactca aacagacgtt     1020

gactttcttt gatgagcttc ataatgttgg cagagatcat gggactagtg attttaggga     1080

gagtttagta tccctggttc agaactccag aaaactacag aacattagag acaatgtgga     1140

aaaggaatcg aaacgactga aaatatctta attgctcagt agtcaaaagg aggagcctgt     1200

caaaaagtag aatcataagg actgttcaaa ccataaggac tgttcaaatc ataccagtga     1260

ctgttcaaac caaccatact ttttattaga tttgctttgt caactctttc ttgtattctg     1320

tgttttcctc ttttttggtc cactttgctg aggtatgaag tgtactactt tgaactaggc     1380

tgaagcatct gagtcttcta ataagtggga agggatccaa caaagaagcc atgaccagtt     1440

aaagatattt gcagagttac accttggtca taagtccttt gtgaccttga ttattttggc     1500

ttactctttg gatgagacca gacaagaaaa ggattaaacg ggtggctcct ttaatattat     1560

tattattgtt tttgagacaa ggtccctttc tgtcacccag gttagagtag atttcagtgg     1620

cacaatcttg gctcactgca acctctgtgt cctgggctca agtgatcctc ctgcctcagc     1680

ctcccaagta gctaggacca caggtgcgtg tcaccatgct tggctaattt ttttgcagaa     1740

acgaggcctc actatattgt ccaggctgag tggctctttt attaaccagt cattacactg     1800

cggaacagcc aacatagagt acttgctctc gtcctgtgaa ttttctttca tgagggagtc     1860

aatatgtagt ggaaagaagc atgtagcaaa aaagacaacc ttgatcttta ataaaaaaga     1920

agttggttta tttccaaaat aaatcccctg acaaaaaacc tggtgatgtt aagcaattga     1980

ctgtcttaga gtccagcaga agaccttaga caaaaaaagc agaacccact ggagtagaaa     2040

aggaagcatg tagcatatac tcagtagtga aatttaattt tactgactgt taggtatcta     2100

tgccaatttg ttttcatact tcagttggtt ttggaatctg ccttatacct aatatttatt     2160

tattcacact cataagcatc aaatatttaa tgccctcagt gggaaatttg tgtttaaact     2220

caatggaatc taatatttct ttatgtcgtt agtccctgta aaatgttagg tcacccaagg     2280

aaaggggaga aatagcaatg gttgttccta aggtattgct tgccctccat gtcttcctaa     2340

agagcagaac ttggagtttc tcctttatgt agagaagaag taacttaggg tgtatttgca     2400

atgaaatatt catagatatt gaaagcttgt gtttacatga aatatgttta ttatcaagaa     2460

gtcctttttc caattctgta cattaaatat atgtgtttta aaggg                     2505


<210> 2132
<211> 2027
<212> DNA
<213> Homo sapiens

<400> 2132
aagtgcggac gcccggctcc cggcgtggac gccatggtgc tgtgcccggt gattgggaag       60

ctgctgcaca agcgcgtggt gctggccagc gcctccccac gccgtcagga gatcctcagc      120

aacgcgggtc tcaggtttga ggtggtcccc tccaagttta aagagaagct ggacaaagcc      180

tccttcgcta ctccgtatgg gtacgccatg gagaccgcca agcagaaggc cctggaggtg      240

gccaaccggc tgtaccagaa agacctgcgg gcccccgacg tggtcattgg agcggacacg      300

atcgtgacag tcggggggct gattctggag aagccggtgg acaagcagga cgcctacagg      360

atgctgtccc ggttgagtgg gagagaacac agcgtgttca caggtgtcgc gatcgtccac      420

tgctccagca aagaccatca gctggacacc agggtctcgg aattctacga ggaaacgaag      480

gtgaagttct cggagctgtc cgaggagctg ctctgggaat acgtccacag cggggagccc      540

atggacaaag ctggcggcta cgggatccag gccctgggcg gcatgctggt ggagtccgta      600

cacggggact ttctgaacgt ggtgggattc ccgctgaacc acttctgcaa gcagctggtg      660

aagctctact acccgccccg tccggaggac ctgcggcgga gtgtcaagca cgactccatc      720

ccggccgcgg acaccttcga agacctcagt gacgtggagg ggggcggctc ggagcccact      780

cagagggacg cgggcagccg cgatgagaag gccgaggcgg gagaggcggg acaggccacg      840

gcagaggctg agtgtcacag gactcgggag accctgcctc cgttcccgac acgcctcctg      900

gagctgattg agggctttat gctatccaag ggcctgctca ccgcttgcaa actgaaggtg      960

ttcgatttgt taaaagatga agcaccccag aaggctgcgg atattgccag caaagtggac     1020

gcctctgcgt gtggaatgga gaggcttctg gacatctgtg ctgccatggg gctcctggag     1080

aagacagagc aaggttacag taacacagag acagcgaacg tctacctggc atcggatggc     1140

gaatactctc tgcacggctt catcatgcac aataatgacc tcacatggaa cctctttaca     1200

tacctggagt ttgccatccg agagggaaca aaccagcacc acagggcgtt ggggaagaag     1260

gcggaagatc tgttccagga tgcgtactac cagagcccgg agacgcggct gaggttcatg     1320

cgggccatgc acggcatgac gaagctgact gcgtgccagg tggccacggc cttcaatctg     1380

tcccgcttct cctccgcctg cgacgtggga ggctgcacgg gtgcactggc ccgagagctg     1440

gcccgtgagt accctcgtat gcaggtgact gtgtttgacc tcccagacat tatcgagctg     1500

gccgcccact tccaaccccc cggaccgcag gcagtgcaga tccacttcgc agcaggtgac     1560

tttttcaggg accccctccc cagcgctgag ctgtacgtcc tgtgccggat cctgcatgac     1620

tggccagacg acaaagtcca caagttactc agcagggtcg ccgagagctg caagccaggg     1680

gccggcctgc tgctggtgga gacgctcctg gatgaggaga agagggtggc gcagcgcgcc     1740

ctgatgcagt cactgaacat gctggtgcag actgaaggca aggagcggag cctgggcgag     1800

tatcagtgct tgctggagct gcacggcttc caccaggtgc aggtggtgca cttggggggt     1860

gtcctggatg ccatcttggc caccaaagtg gccccctgaa gcccaggcag catgttcatt     1920

atagggatgt cctcccccag gctgcaggtg gaccgcccgg tccccaagta ccataggaca     1980

gtcacatagg agcgtgtagt cgtgactgaa taaagaaagc aaaagcc                   2027


<210> 2133
<211> 4059
<212> DNA
<213> Homo sapiens

<400> 2133
gtctgactcc agcgaccgcg cgcgggttcg agggttggcg gcgaggcgct cggtttctct       60

tcttccgtcc acccgcgctt cccgttcccc gtcaccgccg ctggcgtttg tagatttctt      120

tccgccagtg aagctgggtt ttctggagtt ggctctggcg ctctggcccc tggagtgtaa      180

tttcctacac gcagcgccgc agagtttata ttctttgaaa gtgtttgtag ctttgtagag      240

gtcctcttgt tgatggtagg tgagcctaat tctgcaagat aaaagcctag tctctgacct      300

ggcagatgaa agatcaaatc agattgtggt ttcctgctat tagaatgccg tgctattaga      360

ctttaaggct ttttagcctt ctttaaaaaa taaaaaaatt tttacagtgg aagaaaagca      420

caagaagtaa acttttacag tcgttgattt gactataacg ctgatccccc caaatcaaag      480

aatttttact tgttcctgca aagctgctgg agctcagaag ctgattctat cacattgtaa      540

gatgcctttg gataattcta cagtcctctt aaatgaatct ttagaacttg gcaagtctca      600

ctagatacct tcaatcatca ttttgagctc aaagaattct gagacttatg gttggtcata      660

tagaagagta ccttgaacct atagtttcct gaagaatcag tttaaaagat ccaaggagta      720

caaaaggcag ttattggagg aattactcaa caaaaataaa gaagtaaact aaaaaagatg      780

aaggcatagg atacaagtaa cagggaatat gacctaacta gagacccagg gaatcaccag      840

gatgatgatg aataatgatc acaagaagac agcttgtcct caggagaagt acaaatgtct      900

actacaagac gaaaacgtag tatgttatgt tgtttaccgt aagctgtagt aaaatgagct      960

cgattgttga cagagatgac agtagtattt ttgatgggtt ggtggaagaa gatgacaagg     1020

acaaagcgaa aagagtatct agaaacaaat ctgaaaagaa acgtagagat caatttaatg     1080

ttctcattaa agaactggga tccatgcttc ctggtaatgc tagaaagatg gacaaatcta     1140

ctgttctgca gaaaagcatt gattttttac gaaaacataa agaaatcact gcacagtcag     1200

atgctagtga aattcgacag gactggaaac ctacattcct tagtaatgaa gagtttacac     1260

aattaatgtt agaggctctt gatggttttt ttttagcaat catgacagat ggaagcataa     1320

tatatgtgtc tgagagtgta acttcattac ttgaacattt accatctgat cttgtggatc     1380

aaagtatatt taattttatc ccagaagggg aacattcaga ggtttataaa atactctcta     1440

ctcatctgct ggaaagtgat tcattaaccc cagaatattt aaaatcaaaa aatcagttag     1500

aattctgttg tcacatgctg cgaggaacaa tagacccaaa ggagccatct acctatgaat     1560

atgtaaaatt tataggaaat ttcaaatctt taaacagtgt atcctcttca gcacacaatg     1620

gttttgaagg aactatacaa cgcacacata ggccatctta tgaagataga gtttgttttg     1680

tagctactgt caggttagct acacctcagt tcatcaagga aatgtgcact gttgaagaac     1740

ccaatgaaga gtttacatct agacatagtt tagaatggaa gtttctgttt ctagatcaca     1800

gggcaccacc cataataggg tatttgccat ttgaagttct gggaacatca ggctatgatt     1860

actatcatgt ggatgaccta gaaaatttgg caaaatgtca tgagcactta atgcaatatg     1920

ggaaaggcaa atcatgttat tataggttcc tgactaaggg gcaacagtgg atttggcttc     1980

agactcatta ttatatcact taccatcagt ggaattcaag gccagagttt attgtttgta     2040

ctcacactgt agtaagttat gcagaagtta gggctgaaag acgacgagaa cttggcattg     2100

aagagtctct tcctgagaca gctgctgaca aaagccaaga ttctgggtca gataatcgta     2160

taaacacagt cagtctcaag gaagcattgg aaaggtttga tcacagccca accccttctg     2220

cctcttctcg gagttcaaga aaatcatctc acacggccgt ctcagaccct tcctcaacac     2280

caaccaagat cccgacggat acgagcactc cacccaggca gcatttacca gctcatgaga     2340

agatggtgca aagaaggtca tcatttagta gtcagtccat aaattcccag tctgttggtt     2400

catcattaac acagccagtg atgtctcaag ctacaaattt accaattcca caaggcatgt     2460

cccagtttca gttttcagct caattaggag ccatgcaaca tctgaaagac caattggaac     2520

aacggacacg catgatagaa gcaaatattc atcggcaaca agaagaacta agaaaaattc     2580

aagaacaact tcagatggtc catggtcagg ggctgcagat gtttttgcaa caatcaaatc     2640

ctgggttgaa ttttggttcc gttcaacttt cttctggaaa ttcatctaat atccagcaac     2700

ttgcacctat aaatatgcaa ggccaagttg ttcctactaa ccagattcaa agtggaatga     2760

atactggaca cattggcaca actcagcaca tgatacaaca acagacttta cagagtacat     2820

caactcagag tcaacaaaat gtactgagtg ggcacagtca gcaaacatct ctacccagtc     2880

agacacagag cactcttaca gccccactgt ataacactat ggtgatttct cagcctgcag     2940

ccggaagcat ggtccagatt ccatctagta tgccacaaaa cagcacccag agtgctgcag     3000

taactacatt cactcaggac aggcagataa gattttctca aggtcaacaa cttgtgacca     3060

aattagtgac tgctcctgta gcttgtgggg cagtcatggt acctagtact atgcttatgg     3120

gccaggtggt gactgcatat cctacttttg ctacacaaca gcaacagtca cagacattgt     3180

cagtaacgca gcagcagcag cagcagagct cccaggagca gcagctcact tcagttcagc     3240

aaccatctca ggctcagctg acccagccac cgcaacaatt tttacagact tctaggttgc     3300

tccatgggaa tccctcaact caactcattc tctctgctgc atttcctcta caacagagca     3360

ccttccctca gtcacatcac cagcaacatc agtctcagca acagcagcaa ctcagccggc     3420

acaggactga cagcttgccc gacccttcca aggttcaacc acagtagcac acgtgcttcc     3480

tctcttgaca tcaagggagg aaggggatgg cccattaaga gttactcaga tgacctgagg     3540

aaaggaggga aagttccagc agtttcatga gatgcagtat tgagtgttct agttcctgga     3600

attagttggc agagaaaatg ctgcctagtg ctacagatgt acattaaata ccagccagca     3660

ggaggtgatc ataggggcat agccagttct gacagtgttt taggtgcctg gatatttttt     3720

gatggaaaaa gaatatattg ccaaatatta agaagctcag ctatgaaatg acctccaggg     3780

aatcagaaag gcactaatga tgttagtaac ttttagtggt tctgtgcctc ttatcaagtg     3840

ttacagagga cataccactg ccatgtcagg ggtttgctta cagtgatgcc atgaagacag     3900

tccagtagac ttggtagcga ccccctcccc caacccctct cccttttcag ataatgatgg     3960

aacagtaatt actttcagaa tgttgtgtgg gttcaaattc tctatgtaca gatgatgtaa     4020

aaatatgtat atgtctagat aaaaggagag aaagcaaaa                            4059


<210> 2134
<211> 2035
<212> DNA
<213> Homo sapiens

<400> 2134
ctggccgcct gttttttttg cagccgcgct gcgcgcaccg cgggctccgg gctcagaagt       60

gcggacgccc ggctcccggc gtggacgcca tggtgctgtg cccggtgatt gggaagctgc      120

tgcacaagcg cgtggtgctg gccagcgcct ccccacgccg tcaggagatc ctcagcaacg      180

cgggtctcag gtttgaggtg gtcccctcca agtttaaaga gaagctggac aaagcctcct      240

tcgctactcc gtatgggtac gccatggaga ccgccaagca gaaggccctg gaggtggcca      300

accggctgta ccagacagtc ggggggctga ttctggagaa gccggtggac aagcaggacg      360

cctacaggat gctgtcccgg ttgagtggga gagaacacag cgtgttcaca ggtgtcgcga      420

tcgtccactg ctccagcaaa gaccatcagc tggacaccag ggtctcggaa ttctacgagg      480

aaacgaaggt gaagttctcg gagctgtccg aggagctgct ctgggaatac gtccacagcg      540

gggagcccat ggacaaagct ggcggctacg ggatccaggc cctgggcggc atgctggtgg      600

agtccgtaca cggggacttt ctgaacgtgg tgggattccc gctgaaccac ttctgcaagc      660

agctggtgaa gctctactac ccgccccgtc cggaggacct gcggcggagt gtcaagcacg      720

actccatccc ggccgcggac accttcgaag acctcagtga cgtggagggg ggcggctcgg      780

agcccactca gagggacgcg ggcagccgcg atgagaaggc cgaggcggga gaggcgggac      840

aggccacggc agaggctgag tgtcacagga ctcgggagac cctgcctccg ttcccgacac      900

gcctcctgga gctgattgag ggctttatgc tatccaaggg cctgctcacc gcttgcaaac      960

tgaaggtgtt cgatttgtta aaagatgaag caccccagaa ggctgcggat attgccagca     1020

aagtggacgc ctctgcgtgt ggaatggaga ggcttctgga catctgtgct gccatggggc     1080

tcctggagaa gacagagcaa ggttacagta acacagagac agcgaacgtc tacctggcat     1140

cggatggcga atactctctg cacggcttca tcatgcacaa taatgacctc acatggaacc     1200

tctttacata cctggagttt gccatccgag agggaacaaa ccagcaccac agggcgttgg     1260

ggaagaaggc ggaagatctg ttccaggatg cgtactacca gagcccggag acgcggctga     1320

ggttcatgcg ggccatgcac ggcatgacga agctgactgc gtgccaggtg gccacggcct     1380

tcaatctgtc ccgcttctcc tccgcctgcg acgtgggagg ctgcacgggt gcactggccc     1440

gagagctggc ccgtgagtac cctcgtatgc aggtgactgt gtttgacctc ccagacatta     1500

tcgagctggc cgcccacttc caaccccccg gaccgcaggc agtgcagatc cacttcgcag     1560

caggtgactt tttcagggac cccctcccca gcgctgagct gtacgtcctg tgccggatcc     1620

tgcatgactg gccagacgac aaagtccaca agttactcag cagggtcgcc gagagctgca     1680

agccaggggc cggcctgctg ctggtggaga cgctcctgga tgaggagaag agggtggcgc     1740

agcgcgccct gatgcagtca ctgaacatgc tggtgcagac tgaaggcaag gagcggagcc     1800

tgggcgagta tcagtgcttg ctggagctgc acggcttcca ccaggtgcag gtggtgcact     1860

tggggggtgt cctggatgcc atcttggcca ccaaagtggc cccctgaagc ccaggcagca     1920

tgttcattat agggatgtcc tcccccaggc tgcaggtgga ccgcccggtc cccaagtacc     1980

ataggacagt cacataggag cgtgtagtcg tgactgaata aagaaagcaa aagcc          2035


<210> 2135
<211> 1154
<212> DNA
<213> Homo sapiens

<400> 2135
aactccaggg ctagtgagct ggaccggaag taggtttcta cccgaccgca ttttacgtgg       60

tgctgcattt ccggtagcgg cggcgggaaa tcggctgtgg gagagaggct aggcctctga      120

ggaggcgaat ccggcgggta tcagagccat cagaaccgcc accatgacgg tgggcaagag      180

cagcaagatg ctgcagcata ttgattacag gatgaggtgc atcctgcagg acggccggat      240

cttcattggc accttcaagg cttttgacaa gcacatgaat ttgatcctct gtgactgtga      300

tgagttcaga aagatcaagc caaagaactc caaacaagca gaaagggaag agaagcgagt      360

cctcggtctg gtgctgctgc gaggggagaa tctggtctca atgacagtag agggacctcc      420

tcccaaagat actggtattg ctcgagttcc acttgctgga gctgccgggg gcccagggat      480

cggcagggct gctggcagag gaatcccagc tggggttccc atgccccagg ctcctgcagg      540

acttgctggg ccagtccgtg gggttggcgg gccatcccaa caggtgatga ccccacaagg      600

aagaggtact gttgcagccg ctgcagctgc tgccacagcc agtattgccg gggctccaac      660

ccagtaccca cctggccgtg ggggtcctcc cccacctatg ggccgaggag caccccctcc      720

aggcatgatg ggcccacctc ctggtatgag acctcctatg ggtcccccaa tggggatccc      780

ccctggaaga gggactccaa tgggcatgcc ccctccggga atgcggcctc ctccccctgg      840

gatgcgaggc cttctttgac ccttggccac agagtatgga agtagctccg cagaggcgtg      900

ggctcgattc ctcagggcca cgttaccaca gacctgtttg tttcttatgc tgttgttcgt      960

ggagtctcat gggattgtct ggtttccctt acagggcccc ctcccccggg aatgcgccca     1020

ccaaggccct agactcatct tggccctcct cagctccctg cctgtttccc gtaaggctgt     1080

acatagtcct tttatctcct tgtggcctat gaaactggtt tataataaac tcttaagaga     1140

acattataat tgca                                                       1154


<210> 2136
<211> 2301
<212> DNA
<213> Homo sapiens

<400> 2136
gggtggggcg tgttgacccc cttaaaggcg ccagagcccg cggtcacggc tcaggttccc       60

ggtgcttcgc gcgtctgccg ttgtcacagg ccagggaggt ggcaccacca ggcgaagctt      120

ggcgagattg tgtcgtcaag cgcgtacggg cgccaattgg ccgggcgatg tggcgtggac      180

tggcgctggc gcgagcgatt ggctgcgcgg cccgggggcg gggccagtgg gcggtgcgcg      240

ccgcagactg tgctcaaagc gggcgccatc cgggaccggc ggttgtctgt ggccggaggc      300

tgatcagtgt tctagaacag atcagacatt ttgtaatgat gcctgaaata aacactaacc      360

acctcgacaa gcaacaggtt caactcctgg cagagatgtg tatccttatt gatgaaaatg      420

acaataaaat tggagctgag accaagaaga attgtcacct gaacgagaac attgagaaag      480

gattattgca tcgagctttt agtgtcttct tattcaacac cgaaaataag cttctgctac      540

agcaaagatc agatgctaag attacctttc caggttgttt tacgaatacg tgttgtagtc      600

atccattaag caatccagcc gagcttgagg aaagtgacgc ccttggagtg aggcgagcag      660

cacagagacg gctgaaagct gagctaggaa ttcccttgga agaggttcct ccagaagaaa      720

ttaattattt aacacgaatt cactacaaag ctcagtctga tggtatctgg ggtgaacatg      780

aaattgatta cattttgttg gtgaggaaga atgtaacttt gaatccagat cccaatgaga      840

ttaaaagcta ttgttatgtg tcaaaggaag aactaaaaga acttctgaaa aaagcagcca      900

gtggtgaaat taagataacg ccatggttta aaattattgc agcgactttt ctctttaaat      960

ggtgggataa cttaaatcat ttgaatcagt ttgttgacca tgagaaaata tacagaatgt     1020

gaatatgtag gtaaatgatt acagaaaaat ttatctgctt aacaaactta gaatgacttt     1080

ttccttttaa atttagttct atcattaatt tatcattaaa tttagttcta tcatttggta     1140

ctatcattaa tgtattatat acactgatac tttaaaactt gtgtggaaaa aactaactta     1200

taattttgta tcacacaccc tggatatgtg ttctgtttct aagcgacatt tgtgagagat     1260

tattgtaaaa tgagagcgag caaataaaac ttaatttaat ctttgcagat acatacttat     1320

gggaaatttg aacaaatgag tgaaactctg tttttagtag gctgtgataa acatttccgg     1380

agcacttgca gaggacttgc tatttgccag gtgctttatg tatcattaaa tttttctcat     1440

agttcagaaa aatgtgcaaa ggaaactatt gtctcgctcc ttcaaaacag tcttaattaa     1500

ctttcatatt agcagattaa actagcagag caggttcaag ggaaattaaa tgatatggac     1560

cctaatttgt atcattctga gttgattgtg tggtttattc attctggaaa catgttgata     1620

cttacagtca gccactgctt ttgataagtg atattgatta ggttgaatct tcttgtaaat     1680

agtatttacc agttagcaaa gtctgtgttt tcagaattac agtgagcaca gaggtgttca     1740

taaaatggga attgagtccc actcggtaag agttgcttaa acttgacact gttgacattt     1800

gggctggata aaacccctgt ggtggggtct gtgctgtgca ttgcaggatg gtgagcagcg     1860

tccctctcat gtgacaccca cagttatgcc ggatgttgcc agatgcccct aggggacaga     1920

gtcaaccccc aactgaggac cactgtccta cagagtcagg aaatattgta gggagaaaaa     1980

aataacaaca acaaaggcct gtgttaatgt taaatagatg agattatgga atgtgtatat     2040

taatgttaaa aattgtacct tgatcaatgt actttttata aacttgccat agatatctca     2100

gatttgaaac ctcaagacag atttattatt cttaaatgct gtatgataat gaagaaaaat     2160

aaaaatttat ttcttgcaaa gttaaatgtt tgttaaattc aatagaatga ctcatttatg     2220

gttaactttg ggcaatttat aatttcagac aagactgttt agcaagtatt ttattgaaaa     2280

gtaaaaaaaa ttgcaattta a                                               2301


<210> 2137
<211> 1931
<212> DNA
<213> Homo sapiens

<400> 2137
ggccaaccgc ccggacctcg gcgctttctt ctaggatccg catgaatcgc tttgggctat       60

cggaagagct atccccagtt ctcgggagaa agagtccgcg accagcgtct gacctctcac      120

tcagagtccc cagtcctgcc ttagtttccc cagcgaccct gaatttggag ttgctgtctc      180

taagtgaaag ctgaacctgc aaccccttga gggtttcagc cgcagagggg cgggagaaag      240

ggcctggttg gtaggcgggc tcagcggttc gcgcccagtt agccccgagc ttcggagacc      300

cgagagacca gaggatggct gacacgaagg ggcacccgag acagcgcctg ggctttttcc      360

cgcccgcggt tccaccgctc tgaaaccgat ttctaacaga gagagacata gtcttgctct      420

gttacccatg ctggagtacg gtggcgagat cacgactcac tacaactttg aattcctgga      480

ttcaagcaat cctcccatct cagcctcctg agtagctaag gactacaggg cgactttgtc      540

agtaccccaa actgtccccg catgaggtca ctctgcacgg tcacgtgctc gagcccgcgg      600

gagcgccaca tcgccagccg cacccctcca cccccaacct gcccacgtga cccggcctag      660

tttctccagg cccgtcccta cgtctcactc gggaagcccc gccccacgct gagcgctccg      720

cctgcgaccc tccgccactt acccaccccg gctcaagcac gacccgtgga tccacgtgct      780

ttttcttgtc caatgggagc cggctcccgg gcgcgaaggg gcggggagga aaggaacgac      840

tgtgctacgt tgccagaagg ggcgggacct gcaacgtccg acagaacgag gggacgtaac      900

ggaggcaggt tggagccgct gccgtcgcca tgacccgcgg taaccagcgt gagctcgccc      960

gccagaagaa tatgaaaaag cagagcgact cggttaaggg aaagcgccga gatgacgggc     1020

tttctgctgc cgcccgcaag cagagggact cggagatcat gcagcagaag cagaaaaagg     1080

caaacgagaa gaaggaggaa cccaagtagc tttgtggctt cgtgtccaac cctcttgccc     1140

ttcgcctgtg tgcctggagc cagtcccacc acgctcgcgt ttcctcctgt agtgctcaca     1200

ggtcccagca ccgatggcat tccctttgcc ctgagtctgc agcgggtccc ttttgtgctt     1260

ccttcccctc aggtagcctc tctccccctg ggccactccc gggggtgagg gggttacccc     1320

ttcccagtgt tttttattcc tgtggggctc accccaaagt attaaaagta gctttgtaat     1380

tccttgagcg cctggtttga ctggggactt ggggggatgg ggttggaaga atgactgccc     1440

tttcccacca aaaaagggag aactctttag attcagattg tgggtatgta gacttaataa     1500

gtgaaacatc acagaagaag cctttattat acaatgacaa ccaaacaagt actccggata     1560

tgcagtagag gaatcctcta agaaccatag agacttcttt tctgtgattt ttgttcccca     1620

cccttgaaca ccatctctag gatggagttg gcctaagagt gaatgctgca agatctgtgt     1680

ttatgcctct tttcctcatt cttcctcagt ttgttcgtct gcttgaaagt tggccaaaaa     1740

atcctgctgc tcaccgactt cccgtggtca gctgctgtca agcgttcact ttctcttctg     1800

tcattcctca tggaatgagg gtggttttgt cttcccgctt cccttgacct caaaatcagg     1860

attaaaacct ggggtagcct ctgtgctcct ttcttctatg ccctggtttg ttctgtggtt     1920

ctgggcttct t                                                          1931


<210> 2138
<211> 5404
<212> DNA
<213> Homo sapiens

<400> 2138
ggagtcgggg tggcagcggc ggcggttgcc aggagcccgc gttgcagcct gagatccgta       60

atatggcggg gaggaggagg agaaggcggc ggcggaccga gctgcgctct gtcagtacca      120

tttgagccat tcgcttcctg acaaggcccg tggcgagggg agaggagctg aaggggccgt      180

gggggatcag tgtgactgtg ggaagatgga ggagtatgag aagttctgtg aaaaaagtct      240

tgccagaata caagaagcat cactatccac agagagcttt ctccctgctc agtctgaaag      300

tatctcactt attcgctttc atggagtggc tatcctttct ccactgctta acattgagaa      360

aagaaaggaa atgcaacaag aaaagcagaa agcacttgat gtagaagcaa gaaagcaggt      420

taacaggaag aaagctttac tgactcgtgt ccaggagatt cttgacaatg ttcaggttag      480

aaaagcacct aatgccagtg attttgatca gtgggagatg gaaacagttt actctaattc      540

agaagtcaga aacttgaatg ttcctgctac atttccaaat agctttccaa gccatacgga      600

acactctact gcagcaaagc ttgataagat agctgggatt ttgccattgg ataatgagga      660

ccaatgtaaa actgatggaa tagacttagc tagagattca gaaggattta attctccgaa      720

gcaatgtgat agttccaata ttagtcatgt agaaaatgaa gcttttccaa agacctcttc      780

agcaacccca caagaaactc ttatttctga tggtcccttc tcagtaaatg aacaacagga      840

tctaccactt ttggcagaag tcatcccaga tccctatgta atgagtcttc agaatctgat      900

gaaaaagtca aaggaatata tagaaagaga acaatctaga cgcagtctga gaggtagtat      960

caacagaatt gttaatgaga gtcatttaga caaagaacat gatgctgttg aagtggctga     1020

ctgtgtaaaa gagaaaggcc agttgacagg caaacactgt gtctcagtta ttcctgacaa     1080

accaagcctt aataaatcaa atgttcttct ccaaggtgct tccactcaag caagcagcat     1140

gagtatgcca gttttagcta gcttttcgaa agtggacata cctatacgaa ctggccatcc     1200

cactgttcta gagtctaatt ctgattttaa agttattccc acttttgtta ccgaaaataa     1260

tgttatcaaa agtcttacag gttcatatgc caaattacct agtccagagc caagtatgag     1320

tcctaaaatg caccgaagac gttccaggac atcatcagcg tgtcatatac ttataaataa     1380

cccaataaat gcctgtgaat taagccctaa aggaaaagaa caggcaatgg acttaattat     1440

tcaagatact gatgaaaaca caaatgtgcc cgaaattatg ccaaagttac caactgattt     1500

agcgggagtt tgttcaagca aggtttatgt gggcaaaaat acatctgaag tcaaagaaga     1560

tgtggtttta ggtaaatcaa atcaggtatg tcaatcttca ggaaatcatt tagaaaataa     1620

agttactcat ggacttgtta ctgtggaagg tcagttaaca tccgatgaga gaggcgcaca     1680

cataatgaac agtacctgtg ctgcgatgcc aaagctgcat gaaccatatg ccagcagtca     1740

gtgtatagca agtccaaact ttggaactgt gagtggactc aagccagcca gtatgttaga     1800

gaaaaactgc agtttgcaaa cagaactgaa taagtcttat gatgtaaaaa acccttctcc     1860

tttattgatg caaaaccaga atacgagaca gcagatggac acacctatgg tgtcctgtgg     1920

aaatgaacaa tttttggata acagttttga gaaagttaaa cggagacttg atttagatat     1980

tgatggtttg caaaaagaaa actgccctta tgtcataaca agtggaataa ctgaacaaga     2040

aaggcaacat ttgccagaaa aaagataccc taagggatct ggcttcgtta acaagaataa     2100

aatgttagga actagttcca aagaaagcga ggagttacta aaaagcaaga tgttagcttt     2160

tgaagaaatg cggaagagac tagaagaaca gcacgcccag caattatcac tactcatagc     2220

tgagcaggaa agggaacaag aaagactgca aaaggaaata gaagagcagg agaaaatgtt     2280

aaaagagaag aaggcaatga cagcggaagc ctctgagttg gacattaaca atgcagtgga     2340

attagaatgg agaaaaataa gtgactctag tttgctggaa acaatgctgt ctcaagcgga     2400

ctcactccat acttcaaatt caaatagttc tggtttcaca aattctgcca tgcaatatag     2460

ctttgtttct gcaaacgaag caccattcta cctctgggga tcatcaacta gtggcttgac     2520

caaactctca gtaacaaggc cttttggaag agccaaaact agatggtctc aagtttttag     2580

tctggaaata caagcaaaat ttaacaaaat aactgcagtg gcaaaaggat ttcttactcg     2640

tagacttatg cagacagata agctgaagca acttcgacaa actgtaaaag atactatgga     2700

attcataaga agttttcagt cagaagcacc attaaagaga ggcattgttt cagctcaaga     2760

tgcttcactt caggaaagag tgttagctca gttgcgagct gccttgtacg gtattcatga     2820

catattcttt gtaatggatg cagctgaaag aatgtctatt ctacatcatg atcgagaagt     2880

tcgcaaagag aaaatgctca ggcaaatgga taaaatgaaa agtccacgag tggctctttc     2940

agctgcaaca cagaagtctc ttgataggaa gaaatacatg aaagctgctg aaatgggaat     3000

gccaaataag aaatttctgg ttaaacaaaa tccttctgaa acaagagtcc ttcagccaaa     3060

ccaaggacag aatgcacctg ttcataggct acttagtaga caaggaaccc ctaagacatc     3120

agtgaagggg gttgtgcaaa atagacagaa gccttcacag agcagagtgc ctaacagagt     3180

gcctgtttca ggagtatatg caggaaaaat ccaaagaaag cggccaaatg ttgcgacaat     3240

ttaagaagac aacattcatt aggataaaat ggggggaagg attattattc atgttatttt     3300

ccctgcccaa gactttattt aaccctggac tccgtttaca cagacaaagt gacatcagaa     3360

ggctgagcac ttatctggat catttggtca gtttggtaat tcctgctcca cacccctatt     3420

ttcctcttaa taatacgttt gggtgaagac aaattagtgt ttagtaattg catcatctct     3480

gtgcttacct atacaaacat aagtttattt tatatgccca gatgtctaca gagacccttt     3540

ttgtaaatgt caaggacatt tggatttact tttacagaat attgaaaaga taagacaaat     3600

tataaataag ttctaaaaca taaatttaat tcatctctgc atagtgattt ttgaatttga     3660

ttcaaaggga aattattgca gaagaatgcc tttccctcat tttataactt taaaaacttg     3720

gattaaccac tcaatgtcca ctttctttga cttacagtat aaccatgtag ccaattgtgg     3780

cccactaaaa tctacagaag ttaatgtggg tcaccatttt ggtcagaagc atacattcct     3840

gtcagacaac tagttgtctg acagaaatgt taggcttcat gtatgttacc ccagtactgt     3900

tagaaacatt tgtactaggt tataagatct ttctgtgaca ggtaacaaat ttggggaaga     3960

cagcacaatc ttcttgaatg tagctcttgg gaatgcatta ttacatccat ttctgtaaca     4020

taataatatg ttgcatgcag ttatattttc tatttagtct gtatattttg ttcttcatag     4080

tctgtttttt ctagcatgct tgatttagga gagaataaag ggctatataa taataaatcc     4140

agatttccgg ataagaatat tgcctggtta aaattctgca ttgcttaaag acacccatgt     4200

ttaagatttt tcatcactaa catatccatt aaaagtatca actggccagg cagggtggct     4260

cacgcctgta ctcccagcat tttgtgaggc caaggtgggt ggatcacctg aggtcaggag     4320

tttgagacca gcctgaccaa acatggcgaa accccatctg tactgaaaat acaaaaatta     4380

ggcatggtgg tgcatgcctg tagttccagc tacttgggag gctgagacag gcgaattgct     4440

tgaacctggg aggcagaggt tgcagtgagc tgagactgtg ccattgcact ccagtcgggt     4500

taacagagca agacactgtc tcaaaaaaaa aaaaaaaaaa aagtatcaac caacaaatgt     4560

taccaagata acgtgacttc atgagggaga atgtcactat taatttatca taccatttcc     4620

aaaaagggct ttgtgctttt cacataaaat tgagacagtg tatatttaat ctaatttaaa     4680

ttttaaagag atactggtat tttgaaaatg caacctatat atattcttaa tatcctttta     4740

agaatatgga gatgaagatt gttttctcca attttctgtg ccattttaaa tttaactttg     4800

acatccagct atagacagaa ataataagcc accctgggtg taaacttgat tttctttatt     4860

gagatgtatc atgtattgaa tgagtgaacc agaaaattag aagatggtca aaaaaagtcc     4920

aagttaccaa ttttttaaaa tttataggca aagtatcaaa ttgtcttctt aatatgataa     4980

actgtgcttt atcattctga aaactcagga tacagcttat tcatagcatt gtgggtctct     5040

ccagtaagaa agatgctaaa agttttgtgc actttttgtg tgtgtaatgc aaattagtta     5100

aaacaaatag ttttggagaa agttaaaact agctttagag taaggatgag aaacttgagt     5160

gtttttaatt taaagataaa agcctgtgtt ttacacattc ttttttggtg ttcatagctt     5220

cttctcatac aggtgccaga cactgtttgt gcttttgatg gatttttatt tatatacttt     5280

ttttgcttat ttttactttg agtggaatgt tcattaatgt aaattgtatt tatttttata     5340

cttttatttt cactagtttt gcttctaggc aaaaagcaaa ataaactttt catcttaaag     5400

aaaa                                                                  5404


<210> 2139
<211> 611
<212> DNA
<213> Homo sapiens

<400> 2139
cgggaagctg gagcgggccg gcggtgcagt cacgggggag cgaggcctgc tgggcttggc       60

aacgagggac tcggcctcgg aggcgaccca gaccacacag tgattctctt ctaccttcct      120

tagacactgg gtcaaggagt aagcagagga taaacaactg gaaggagagc aagcacaaag      180

tcatcatggc ttcagcgtct gctcgtggaa accaagataa agatgcccat tttccaccac      240

caagcaagca gagcctgttg ttttgtccaa aatcaaaact gcacatccac agagcagaga      300

tctcaaagat tatgcgagaa tgtcaggaag aaagtttctg gaagagagct ctgccttttt      360

ctcttgtaag catgcttgtc acccagggac tagtctacca aggttatttg gcagctaatt      420

ctagatttgg atcattgccc aaagttgcac gcactgcctc cttacctgtg aggaatgcaa      480

aataaagcat ggattaagtg agaagggaga ctctcagcct tcagcttcct aaattctgtg      540

tctgtgactt tcgaagtttt ttaaacctct gaatttgtac acatttaaaa tttcaagtgt      600

actttaaaat a                                                           611


<210> 2140
<211> 1594
<212> DNA
<213> Homo sapiens

<400> 2140
ttttgagccc ctgtctggat gacttcttgc ggctgttcta cccctccccc tccccgcggt       60

accttgcact tttctccctc cctgccccct ctcgagtcca ccctccgggc cttctgcccc      120

tgatcgcttg gttttccttg cagtcgcctg ctgctgtcgt cgggaggtgg gtgaggtgac      180

gcaaacagcc ccgttgttgc cctccgcgta tcccctcacc acctttgcgg ccatccacga      240

ctttcgcacc ttccgccatt ttcctgcctg tgagggtgga cagatcgcgc tcgggtctcg      300

gcctcctgag tgccggtgac tgcgggaggc gacggagtgc ttctgggggt gtgagctggg      360

gaagttcgtg gtcacggatg cgtgtggggt tgctgctcag tctgtaacgg caggaaagat      420

gaatgggagg gctgattttc gagagccgaa tgcagaggtt ccaagaccaa ttccccacat      480

agggcctgat tacattccaa cagaggaaga aaggagagtc ttcgcagaat gcaatgatga      540

aagcttctgg ttcagatctg tgcctttggc tgcaacaagt atgttgatta ctcaaggatt      600

aattagtaaa ggaatacttt caagtcatcc caaatatggt tccatcccta aacttatact      660

tgcttgtatc atgggatact ttgctggaaa actttcttat gtgaaaactt gccaagagaa      720

attcaagaaa cttgaaaatt ccccccttgg agaagcttta cgatcaggac aagcacgacg      780

atcttcacca cctgggcact attatcaaaa gtcaaaatat gactcaagtg tgagtggtca      840

atcatctttt gtgacatccc cagcagcaga caacatagaa atgcttcctc attatgagcc      900

aattccattc agttcttcta tgaatgaatc tgctcccact ggtattactg atcatattgt      960

ccaaggacct gatcccaacc ttgaagaaag tcctaaaaga aaaaatatta catatgagga     1020

attaaggaat aagaacagag agtcatatga agtatcttta acacaaaaga ctgacccctc     1080

agtcaggcct atgcatgaaa gagtgccaaa aaaagaagtc aaagtaaaca agtatggaga     1140

tacttgggat gagtgaaaaa ttacatcatt ggacatgaag gagtttcaac atccagcttc     1200

atctaggtgg tcatgattac ctgcatgctt tgagctcagc agcagtcttc ataaacacat     1260

ttaaaacaag atcctgggtt tttgtggttt gacttctatg gtgttttaaa aaaacacaga     1320

tttttagtgt taatattgtg taaatgtact caccttaggg attcatttga atgatggtat     1380

tataccatga ttgtatacag tttgtgaaat tgttgcaagg gcaaagataa ctcttaaaaa     1440

accgtcgaga ttacaatgct ctagaatcag catataagaa aataaatgat atctgcatgt     1500

tgaattgggg tggatggggg gagcaagcat aatttttaag tgtgaagctt tgcatcaaga     1560

aattattaaa aagctttttt tctccagtat tttc                                 1594


<210> 2141
<211> 1593
<212> DNA
<213> Homo sapiens

<400> 2141
ccggcggtgc tcgcaagcga ggcagccatg tcttatcccg ctgatgatta tgagtctgag       60

gcggcttatg acccctacgc ttatcccagc gactatgata tgcacacagg agatccaaag      120

caggaccttg cttatgaacg tcagtatgaa cagcaaacct atcaggtgat ccctgaggtg      180

atcaaaaact tcatccagta tttccacaaa actgtctcag atttgattga ccagaaagtg      240

tatgagctac aggccagtcg tgtctccagt gatgtcattg accagaaggt gtatgagatc      300

caggacatct atgagaacag ctggaccaag ctgactgaaa gattcttcaa gaatacacct      360

tggcccgagg ctgaagccat tgctccacag gttggcaatg atgctgtctt cctgatttta      420

tacaaagaat tatactacag gcacatatat gccaaagtca gttttcagtc attcagtcag      480

taccgctgta agactgccaa gaagtcagag gaggagattg actttcttcg ttccaatccc      540

aaaatctgga atgttcatag tgtcctcaat gtccttcatt ccctggtaga caaatccaac      600

atcaaccgac agttggaggt atacacaagc ggaggtgacc ctgagagtgt ggctggggag      660

tatgggcggc actccctcta caaaatgctt ggttacttca gcctggtcgg gcttctccgc      720

ctgcactccc tgttaggaga ttactaccag gccatcaagg tgctggagaa catcgaactg      780

aacaagaaga gtatgtattc ccgtgtgcca gagtgccagg tcaccacata ctattatgtt      840

gggtttgcat atttgatgat gcgtcgttac caggatgcca tccgggtctt cgccaacatc      900

ctcctctaca tccagaggac caagagcatg ttccagagga ccacgtacaa gtatgagatg      960

attaacaagc agaatgagca gatgcatgcg ctgctggcca ttgccctcac gatgtacccc     1020

atgcgtattg atgagagcat tcacctccag ctgcgggaga aatatgggga caagatgttg     1080

cgcatgcaga aaggtgaccc acaagtctat gaagaacttt tcagttactc ctgccccaag     1140

ttcctgtcgc ctgtagtgcc caactatgat aatgtgcacc ccaactacca caaagagccc     1200

ttcctgcagc agctgaaggt gttttctgat gaagtacagc agcaggccca gctttcaacc     1260

atccgcagct tcctgaagct ctacaccacc atgcctgtgg ccaagctggc tggcttcctg     1320

gacctcacag agcaggagtt ccggatccag cttcttgtct tcaaacacaa gatgaagaac     1380

ctcgtgtgga ccagcggtat ctcagccctg gatggtgaat ttcagtcagc ctcagaggtt     1440

gacttctaca ttgataagga catgatccac atcgcggaca ccaaggtcgc caggcgttat     1500

ggggatttct tcatccgtca gatccacaaa tttgaggagc ttaatcgaac cctgaagaag     1560

atgggacaga gaccttgatg atattcacac aca                                  1593


<210> 2142
<211> 3881
<212> DNA
<213> Homo sapiens

<400> 2142
aggccgccgc ctgggtcgct caacttccgg gtcaaaggtg cctgagccgg cgggtcccct       60

gtgtccgccg cggctgtcgt cccccgctcc cgccacttcc ggggtcgcag tcccgggcat      120

ggagccgcga ccgtgaggcg ccgctggacc cgggacgacc tgcccagtcc ggccgccgcc      180

ccacgtcccg gtctgtgtcc cacgcctgca gctggaatgg aggctctctg gaccctttag      240

aaggcacccc tgccctcctg aggtcagctg agcggttaat gcggaaggtt aagaaactgc      300

gcctggacaa ggagaacacc ggaagttgga gaagcttctc gctgaattcc gagggggctg      360

agaggatcac ctcctacgac ttccacagcg agagtggcct cttcctcttc caggccagca      420

acagcctctt ccactgccgc gacggcggca agaacggctt catggtgtcc cctatgaaac      480

cgctggaaat caagacccag tgctcagggc cccggatgga ccccaaaatc tgccctgccg      540

accctgcctt cttctccttc atcaataaca gcgacctgtg ggtggccaac atcgagacag      600

gcgaggagcg gcggctgacc ttctgccacc aaggtttatc caatgtcctg gatgacccca      660

agtctgcggg tgtggccacc ttcgtcatac aggaagagtt cgaccgcttc actgggtact      720

ggtggtgccc cacagcctcc tgggaaggtt cagagggcct caagacgctg cgaatcctgt      780

atgaggaagt cgatgagtcc gaggtggagg tcattcacgt cccctctcct gcgctagaag      840

aaaggaagac ggactcgtat cggtacccca ggacaggcag caagaatccc aagattgcct      900

tgaaactggc tgagttccag actgacagcc agggcaagat cgtctcgacc caggagaagg      960

agctggtgca gcccttcagc tcgctgttcc cgaaggtgga gtacatcgcc agggccgggt     1020

ggacccggga tggcaaatac gcctgggcca tgttcctgga ccggccccag cagtggctcc     1080

agctcgtcct cctccccccg gccctgttca tcccgagcac agagaatgag gagcagcggc     1140

tagcctctgc cagagctgtc cccaggaatg tccagccgta tgtggtgtac gaggaggtca     1200

ccaacgtctg gatcaatgtt catgacatct tctatccctt cccccaatca gagggagagg     1260

acgagctctg ctttctccgc gccaatgaat gcaagaccgg cttctgccat ttgtacaaag     1320

tcaccgccgt tttaaaatcc cagggctacg attggagtga gcccttcagc cccggggaag     1380

atgaatttaa gtgccccatt aaggaagaga ttgctctgac cagcggtgaa tgggaggttt     1440

tggcgaggca cggctccaag atctgggtca atgaggagac caagctggtg tacttccagg     1500

gcaccaagga cacgccgctg gagcaccacc tctacgtggt cagctatgag gcggccggcg     1560

agatcgtacg cctcaccacg cccggcttct cccatagctg ctccatgagc cagaacttcg     1620

acatgttcgt cagccactac agcagcgtga gcacgccgcc ctgcgtgcac gtctacaagc     1680

tgagcggccc cgacgacgac cccctgcaca agcagccccg cttctgggct agcatgatgg     1740

aggcagccag ctgccccccg gattatgttc ctccagagat cttccatttc cacacgcgct     1800

cggatgtgcg gctctacggc atgatctaca agccccacgc cttgcagcca gggaagaagc     1860

accccaccgt cctctttgta tatggaggcc cccaggtgca gctggtgaat aactccttca     1920

aaggcatcaa gtacttgcgg ctcaacacac tggcctccct gggctacgcc gtggttgtga     1980

ttgacggcag gggctcctgt cagcgagggc ttcggttcga aggggccctg aaaaaccaaa     2040

tgggccaggt ggagatcgag gaccaggtgg agggcctgca gttcgtggcc gagaagtatg     2100

gcttcatcga cctgagccga gttgccatcc atggctggtc ctacgggggc ttcctctcgc     2160

tcatggggct aatccacaag ccccaggtgt tcaaggtggc catcgcgggt gccccggtca     2220

ccgtctggat ggcctacgac acagggtaca ctgagcgcta catggacgtc cctgagaaca     2280

accagcacgg ctatgaggcg ggttccgtgg ccctgcacgt ggagaagctg cccaatgagc     2340

ccaaccgctt gcttatcctc cacggcttcc tggacgaaaa cgtgcacttt ttccacacaa     2400

acttcctcgt ctcccaactg atccgagcag ggaaacctta ccagctccag atctacccca     2460

acgagagaca cagtattcgc tgccccgagt cgggcgagca ctatgaagtc acgttgctgc     2520

actttctaca ggaatacctc tgagcctgcc caccgggagc cgccacatca cagcacaagt     2580

ggctgcagcc tccgcgggga accaggcggg agggactgag tggcccgcgg gccccagtga     2640

ggcactttgt cccgcccagc gctggccagc cccgaggagc cgctgccttc accgccccga     2700

cgccttttat ccttttttaa acgctcttgg gttttatgtc cgctgcttct tggttgccga     2760

gacagagaga tggtggtctc gggccagccc ctcctctccc cgccttctgg gaggaggagg     2820

tcacacgctg atgggcactg gagaggccag aagagactca gaggagcggg ctgccttccg     2880

cctggggctc cctgtgacct ctcagtcccc tggcccggcc agccaccgtc cccagcaccc     2940

aagcatgcaa ttgcctgtcc cccccggcca gcctccccaa cttgatgttt gtgttttgtt     3000

tggggggata tttttcataa ttatttaaaa gacaggccgg gcgcggtggc tcacgtctgt     3060

aatcccagca ctttgggagg ctgaggcggg cggatcacct gaggttggga gttcaagacc     3120

agcctggcca acatggggaa accccgtctc tactaaaaat acaaaaaatt agccgggtgt     3180

ggtggcgcgt gcctataatc ccagctactc gggaggctga ggcaggagaa tcgcttgaac     3240

ccgggaggtg gaggttgcgg tgagccaaga tcgcaccatt gcactccagc ctgggcaaca     3300

agagcgaaac tctgtctcaa aataaataaa aaataaaaga cagaaagcaa ggggtgccta     3360

aatctagact tggggtccac accgggcagc ggggttgcaa cccagcacct ggtaggctcc     3420

atttcttccc aagcccgagc agagggtcat gcgggcccca caggagaagc ggccagggcc     3480

cgcggggggc accacctgtg gacagccctc ctgtccccaa gctttcaggc aggcactgaa     3540

acgcaccgaa cttccacgct ctgctggtca gtggcggctg tcccctcccc agcccagccg     3600

cccagccaca tgtgtctgcc tgacccgtac acaccagggg ttccggggtt gggagctgaa     3660

ccatccccac ctcagggtta tatttccctc tccccttccc tccccgccaa gagctctgcc     3720

aggggcgggc aaaaaaaaaa gtaaaaagaa aagaaaaaaa aaaaaaagaa acaaaccacc     3780

tctacatatt atggaaagaa aatatttttg tcgattctta ttcttttata attatgcgtg     3840

gaagaagtag acacattaaa cgattccagt tggaaacatg t                         3881


<210> 2143
<211> 9744
<212> DNA
<213> Homo sapiens

<400> 2143
gcgcggcgcg ggagagcgca gtggcgccgg cgggaaaggg ctgcggacct gcggcgccgc       60

gttgtgcgtt cgacgacgcg gcaccggctt cgacgccctc tgcccgctcc agaagcagta      120

agaagacatg ttggataaca agaagaggtg tagagtttgc atatatcaac tgtggcctta      180

atgagcatgt tgacagcatc gatgctagac agacagtctt tttactgctg gattgtgcaa      240

gatatttaac cctattttgt ttgaattatg acttaaatgt caaacatctt aactaagaaa      300

agggaaacat tttagttttg gaagtcagaa tgccaaggag aaggaaaaat cttgggggaa      360

atccttttcg gaagactgca aaccctaagg aagttgtcgt atccagtgtt gctagtcgtg      420

aggagccaac cactactcta ccttccatgg gtgagacaaa agttgatcag gaagaactct      480

tcaccagtat ctcagagata ttttctgatc tggatcctga tgtagtgtat ttgatgcttt      540

ctgaatgtga tttcaaaggt gagaaaaagt ttagtttgaa ccctgtccat cttataagaa      600

gactttgtgt actatgccat gattaatagt aatatagaaa aatgtcttga aaatgctatg      660

gattgtctat tagaattatc tgccactgat accaagatag aagaatcatc ttcacaaagt      720

ttcgttgctt ctgagaacca agtaggtgca gcagaaagta aaataatgga aaaacgtcct      780

gaagaagaga gtgaagattc aaaaatggat tcatttttgg acatgcagct aactgaagac      840

ctggattcct taatacagaa tgcttttgag aaattgaact cttctcctga tgaccaagta      900

tactcatttt tgccttcaca agatgttaat agttttaatg actcaagtga gtttataaat      960

cctgattcaa gtaatatgac tcccattttt tctacacaaa atatgaattt gaacggtgaa     1020

aatttagaga attctggttc tactttaagt ttaaacccat taccttcaca ttcagttttg     1080

aacgagtcca agtgttttat aaaggataac acattggctt tggaaagtaa ctacccggaa     1140

gattctcttc tcagtagttc tttaaatgta gcaagtgact ccatcgcagg ttgtagcagt     1200

ctcaatcaaa aacagaaaga acttttagaa tctgagtgcg ttgaggctca attctctgaa     1260

gctcctgtag atttggatgc cagtgaacct caggcttgtt taaaccttcc agggcttgat     1320

ttaccaggta caggtgggga tcagaaatct actcgggtct ctgatgtgtt tctaccttcc     1380

gaagggttca acttcaagcc acacaaacat cctgaactgc caactaaggg gaaggatgtg     1440

agttactgcc cggtacttgc tcctctccca ttgctgttgc ctcctccgcc acctccaccg     1500

atgtggaatc caatgattcc tgcttttgac ctcttccaag gaaaccatgg ctttgtagct     1560

cctgttgtaa ccacagctgc acactggaga tctgtcaact acacatttcc accctcagtt     1620

atttctcaca cttccccaac aaaagtatgg agaaataaag atggaacaag tgcttatcaa     1680

gtacaagaaa ccccagtttc tcaggttgta agaaagaaga catcttacgt tggactagtt     1740

cttgttcttc tcagaggtct tccgggatct ggaaaatctt ttttggcaag gactttgcaa     1800

gaggataatc caagtggagt cattcttagt actgatgatt atttttatat aaatggacag     1860

taccagtttg atgtaaagta cttaggagaa gcacatgaat ggaaccagaa tcgtgcaaaa     1920

gaagcatttg agaagaagat atctcctata attatagata atacaaacct acaggcatgg     1980

gaaatgaaac catatgttgc tttgtctcag aaacacaaat ataaagtcct ttttcgggaa     2040

ccagacacat ggtggaagtt taaaccaaag gaacttgcaa ggcgtaacat tcatggggta     2100

agcaaagaaa aaataacaag aatgttggaa cattatcaac gttttgtttc agtgccaata     2160

attatgagtt cttcggttcc agagaaaatt gaacgtattg agttgtgtgc atattcttgt     2220

gaggatagaa gcactagccc aagagacgat gaagatatta tctctgaaaa agaagaaaat     2280

attttatctt tatctttgaa gcatctagag ttcactgaag agaagaatct tgatgtaacc     2340

aaagaaacaa tgttacctga gaatgttgca tatctctcta atgcagattt aaacaaaaga     2400

agaaaagaaa taagtgatat gaatcctagc attcaaagtg ctttaattct ggaaactcca     2460

cacatgtatt tttctgactc tgaaagcaaa ctacaggcaa cagacaaaag tgaaaacgag     2520

caaatagaaa tggtggctgt aaaagggtat agtaaaactg acacagatag ttctatggag     2580

agagtatcac ctagtacttg ctgtagtgaa aataatcaag aagactgtga tcttgcaaat     2640

agtggaccac ttcaaaatga aaaatcctca cctggtgaaa tagtggaaga aagagcaaca     2700

gtaacgaaaa aagcctttgg gaaacaaaaa agcaaatcga ctttggaaaa gttcccaaga     2760

catgagctat caaattttgt tggtgactgg ccagttgata agactattgg tcagaggaca     2820

aaaaggaaca gaaaaactga aaaaacttca tccgtacaaa gcgacaaaaa gtataattac     2880

cctcagtcac acaaattagt taacagtgta tctgtgaata cagattgtgt ccagcaacga     2940

ggatctccac atgaaagtgt agaggatggc agaaagtcac agtgtgatga tgcttcagag     3000

ccactcaata gctataaata tgatgcttat aaaaatattg acaaaaactc attcaacatt     3060

atgggtgact ggccttcatc tgattcttta gctcagaggg aacacagatc aagaatgcca     3120

aagactggtt taagtgagcc caacctagaa attggaacaa atgacaaaat gaatgaaata     3180

tccttatcta cagcacatga ggcctgttgg ggcacaagct ctcaaaaact aaagacattg     3240

ggtagctcca atctaggaag ttctgaaatg ctgctcagtg aaatgacctg tgagagtcag     3300

acttgtctaa gtaaaaagag tcatgggcaa cacacatcgt tgcctcttac ttttaccaat     3360

agtgcaccaa ctgtttctgg agtagtagaa ccacaaacgt tagctgaatg tcaagagcaa     3420

atgcctaaga gagaccctgg aaaagaagta ggcatgtgca cccagactga accacaggat     3480

tttgctcttt tatggaaaat agaaaagaat aaaattagca tttcagattc tatcaaagta     3540

ttaacaggaa gattagatgg atttaagccg aaagttttca atattaacac aaaatcagac     3600

gttcaagaag caattccata tagagtaatg tatgataaaa gcacgtttgt tgaagaaagt     3660

gagcttacca gtgcagatga atctgaaaat cttaacattc tttgtaaact gtttggatcc     3720

ttttcattag aagccctgaa agacttatat gagaggtgca ataaagatat tatttgggcc     3780

acaagccttt tgttggattc tgaaactaag ttatgtgagg atacagagtt tgagaatttc     3840

caaaaatcgt gtgatggatc acaaattggg cctttttctc tggggttgaa tttgaaagaa     3900

attattagcc aaagaggaac tttagagaat tctaattctc ctgtgccaga gtttagccat     3960

gggattggta ttagtaacgc tgactcacag tctacttgtg atgcagaaag aggaaactca     4020

gagcaggcgg aaatgagagc tgtcactcct gaaaaccatg aatcgatgac aagtatattt     4080

cccagtgctg ctgtgggtct aaagaataat aatgacatac ttcctaacag ccaggaagaa     4140

cttttatata gcagtaagca gtcctttcca ggtattctaa aagctactac tcctaaagat     4200

atgagtgaaa cagaaaaaaa cctagtagtc acagagactg gagacaacat acattctcct     4260

tcacatttct ctgatatttt taactttgta tctagtactt caaatcttga attaaatgaa     4320

gaaatttatt ttactgattc tcttgaaata aagagaaatg aaaattttcc aaaggattat     4380

gtgaaatttt cagatgaaga agaatttatg aatgaagatg agaaggaaat gaaggaaatt     4440

ctaatggcag gaagtagttt atcagctgga gttagtgggg aagataaaac cgagatattg     4500

aatcccactc cagcgatggc caaatctctg accatagact gtctggaatt ggcattaccc     4560

cctgaactgg cttttcaact taatgaatta tttggtcctg ttggtattga ttcagggtct     4620

ctaacagttg aagattgtgt ggttcatata gatctgaatc tggcgaaagt gattcatgag     4680

aaatggaaag aatctgtaat ggagcgacaa agacaagaag aggtgtcttg tggcaagttt     4740

atgcaagatc cttccttggt tggacatact gggcttgata atcctgaaca aaaatcatct     4800

cagagaacag gcaaaaaatt actgaagact ttaacagcat ctgaaatgct acctttattg     4860

gatcattgga atactcaaac taaaaaagta tcactcagag aaataatgtc agaagaaatt     4920

gccttacagg aaaaacataa tttgaaaagg gagaccctta tgtttgaaaa agattgtgcc     4980

actaaactaa aggagaagca gctctttaag atatttccag ccattaacca aaattttctg     5040

gtggacattt tcaaggacca caactattca ttagaacaca cagtgcaatt tcttaactgt     5100

gttcttgaag gggaccctgt aaaaacagtt gtagcccaag agtttgttca ccaaaatgag     5160

aatgtcacat ctcatactgg ccagaagtct aaagagaaaa agccaaagaa attaaaagag     5220

actgaagaaa caccaagtga actgtctttc caggactttg agtacccaga ctatgatgac     5280

tacagagcag aggctttcct tcaccaacag aagaggatgg agtgctacag caaggccaaa     5340

gaagcttatc ggatagggaa aaaaaatgtc gccacctttt atgcccagca gggtactctt     5400

catgagcaga agatgaaaga agccaatcac cttgctgcca tagagatctt tgagaaagtc     5460

aatgcttcgc tgctgccaca gaatgtttta gacctccatg ggctgcatgt ggatgaagct     5520

ctagaacatt tgatgagagt tttagagaag aagactgaag aatttaagca gaacggtggg     5580

aagccctatt tgtctgtgat tacggggaga ggaaaccaca gccagggagg agttgctcgc     5640

atcaaaccag ctgtcattaa gtacctcata agccatagct tcaggttctc tgaaattaaa     5700

ccagggtgct tgaaagtcat gctaaagtaa aataaacatc cttgaattag aagtatgaag     5760

gtttgtaggt taaaattact tttatttgca gtaattcagt caattctacc ctaaagatgt     5820

gttttattat aaataatatt caattatgaa acaaaaaaat tatgatgttt ttcaaaatgc     5880

aagtgaggtt tgatttttta ctgaatcaaa tgcaaatgtt acctgttaaa gatattacag     5940

agaaatttta ttgattacaa aatatgtaag aaaattatca gctacagttt taaagtttaa     6000

aatgctctga ttgtttctca gaaaaggtta cctttgtatt aattgttgta tgacatttag     6060

taatgtccta aaagtctttt gtgagaggta tttaaagtgc tttgagacct gattcatgcc     6120

ccccaaaggg tggtattaaa agaggaaaaa ggacatagta gtggtagtaa agaaaaaaag     6180

gagatctaac aaaaacactt gaatattttt tattttcaaa actaaacaca taaaatgctt     6240

ttattttgcc atatcctaca ggaaggaaga catgcttttg ccctttcttc tgctttgtat     6300

atgaccttga tcttttacct tttgttctgt tcttctgtgt gcattttatg gaaagaaagt     6360

tgggtctgag attatattgt aattttatac tttctataga cagaaaggtt ttcagagaaa     6420

aagaaatggt taaatatctt ccagatgttg ctgccttatc gaaatgcttc tagaactgtc     6480

tgtataagtc gtatttcaga cagtactaaa tacttatatt ttatttttga ggcatgtaat     6540

tttaaaactg cagtaggtta aaattctatt aaacaaatat agaaaatatt ttgtttataa     6600

ttggcctggt gtggtggccc acgcctgtaa tcccagcact ttgggaggcc gaggtaggtg     6660

gatcgcctga ggtcagaagt tcaagaccag cctggccaac atggtgaatc cccgtctcta     6720

ttaaaaatac aaaaattagc tgggtgtggt ggcgtgtgcc tgtaatccca gctacttggg     6780

aggctgaggc aggagaaccg cttaaacctg ggaggtggag gttgcagtga cccgagatcg     6840

agatcacacc actgcactca gcctgggtga cagagcaaga ctccgtctcc aaaaaaaaaa     6900

aagaaaaaaa agagaaaata ttttggttat aatcataaga agaatcctta caatttaaaa     6960

tattttcact tttattttga aaaagagcca actttctcaa aggaagctgt cattaacttc     7020

tgttgtttgg ttagctaata aattctgtta gtatgcaagt taaacctgtg taaaggaggt     7080

tataatgtgg taaggtataa ttttccaata tgagacaatg gcttaaattt gcctttggag     7140

atggagaata ttttcaacat acataatttt aacaaatagt tttgttgctt tttgttaagc     7200

ttaaaaaaaa atttggatca gaaattatag gattgagctg gtaccaaaag aatcctaaag     7260

tacagaatgg ttttccaaaa gagcagacat ttcaatgaaa ataaaacccc aaaacatttt     7320

ttttatatat catgattgca tgcttttaaa ataaggaggc ttatcattga attttagttc     7380

cataaaaatg aaaatacatg tttattattt agaaatggtt agtgactggt attgaagtat     7440

tattcacact tatgtttgta ataatttatt taaagaatgc caacagttta gcacactttt     7500

gtaatctcta gaacagttct atacattaaa aataaacatt aaaaataaag cagttccttt     7560

aaacaactta ctatgaaact ataattgtta atgaaataag atattcctat gtatacatta     7620

gtatgattta agggtatgaa aaacagtgct aaaatgtgga gttaattgga atgtgtgcag     7680

ctgcatactc actttctgtg tttttatatt tccttaccta gttttaaaaa tcatcacttt     7740

tcggcacttc agctagactt atttcaatat tataattatg attaatgaag gagcagtcag     7800

aagtagaggt gtggtattcc gtgggcagaa gtcaaatgaa aaaagctata ttgtttactt     7860

gtttactata tcaatgttaa tattatgcct tattttgata aatcaaatag tatatcttaa     7920

tcattgttga taaatataca ggcaaagttt gagcatcata tgtattttta tgaagctgct     7980

taattccaaa ttgcctccca ccccactatc tagcatagtt taagcaacac ataattttga     8040

aagaaaagtt tgtaatccct cctttctttt ttttgcccat ttctaaatcc tgtatgcccg     8100

cagtaaagat agtttgggga ttttaaaagt tttctctatt acccatttct aaatcctgta     8160

tgtcaaagat agtttggaga ttataaaaat tttcatgtat tggtgtaggt tgagtatccc     8220

taatgagaaa attcaaaatc tgaaatgctt caaaatctga aatttttcga gcacagacat     8280

gatgctcaaa ggaaatactc acagagcatt ttacatttgt aggttagcga tactcaacaa     8340

gtaaatataa tgcacatgtt ctaaaatatc cccccaaacc ccagcaatcc aaaacacttc     8400

tggtcctaag cattttgagt aggggatact cactcaacct gtatatttgt gctaatacat     8460

gactcattag aatgattctt tgtaaactta atattttaaa agtacagcac ttctgtagta     8520

tggaaggttt cagtaataat tatattcatt cagtagtctc ttaccattat ctcccagatg     8580

gaaaaagagg actaatgtgg aaaccccaga gggtgtccag ttggaccagg gagatattag     8640

acacttaaca gtattttcag tctgtccatc tctttattcc aatgtgagaa atggaagtgt     8700

tttttttttt acgtttattg gctcttcata tttctctaca ttatttttaa tgtgcagttt     8760

cttcaattgg ttagtatttc catactattt gcaactttat ggcctttaaa tataggacat     8820

attatatagc agaaattttg actttaaatc ctcttgagta gtatattttg agaagaaaag     8880

ctatactgct cttctggatg gtttccatcc tttatttagg tcttttcttt ttgaattcaa     8940

gtgttttgta tgcttagaaa gtagacatgt ataatattga gatcggttat ttctgagctg     9000

gaaattggaa actttggaaa ctcaggaaat tgctctgaca atgttttaac tgctctcaat     9060

ttaagaaaat gacgaaatgt ataaaaaaga caaaaataac gtgtgctgtt ttttccaagt     9120

gctttttcta agtgcttttc cattgtgcaa tgaggtgaag tttggtaatt tttcggtgta     9180

gtagttaaat attgctcaat ttttatttac atgtaaagaa aacagattta aatgtttatg     9240

tggccaaaag gtgtcattta aaaggtaaaa taagtttatg tagaatgtat gttcatggtg     9300

cttattttta aaatgtaatt caagtttaca gtattactta atgcttcttt acagaattta     9360

atagagaaac aaggctagaa cacatctaca tcctgaagag ccgtttataa cttcatatta     9420

tatgatgaca aagttcatta ttttccttaa agttgagcaa ttgactttta tggtccaatg     9480

atgaacttat tattaataaa tgattgagtt aactgtgagg cttctcatta aaatacaata     9540

ttgcagctat cagttggaga atatattata aaattttcag acagtatatc agaaaaatgt     9600

ttttatttgt actgtataga aaatgtaatt ttgctgttaa ctctgtactt tttaaattga     9660

aaatgtttta taaatttgct tttaaatttt cttatgaagc catttgcaaa ttacatactt     9720

aatttaataa aatactttag ccac                                            9744


<210> 2144
<211> 2738
<212> DNA
<213> Homo sapiens

<400> 2144
gctcgcaccc ccgtcctccg gccgcgaccc ccgcccggga accctagccc ctggccgcgg       60

tcgcttcccg gacctcgccc cgcgcctccc cctgcagccc gccccggccg caccccctag      120

cgtccccgcc cccggccgcg ccccctcatg ggggccccct cggcggtccg ggaggcggcg      180

ggcgcgccat gggcagcggc agcagccgga gcagccggac tctgaggcgg cggcgcagcc      240

ccgagagcct ccccgcgggg cccggagcgg cagccctgga gggcgggacc cgccggcggg      300

tgccggtggc ggcggccgag gtcccggggg cagccgcgga ggaggcgccc ggccgcgacc      360

ccagccccgt ggcgcccccc gacggcaggg acgagacgct gcgcctgctg gacgagctgc      420

tggccgagtc ggcggcctgg ggccccccgg agcccgcccc gcgccgccca gcccggctcc      480

gacccaccgc ggtcgcgggg agcgcggtgt gcgcagagca gagcacagag ggccacccgg      540

ggagcggcaa tgtctctgaa gccccaggca gcggtcgcaa gaagcccgag aggccggcag      600

ccatctccta cgaccactcg gaagaggggc tgatggcgag catcgagcgg gagtactgcc      660

gctgaggaca gcatgctcca cccccgccag gcctcggagg cacctgctgg ctggggcacc      720

ctctgcttgc acagagctct agcaggagct gaaccacctc caaaacgcag tcactcccgg      780

atattcaaag ctgccctttc aaatccactt tcagaccgcg ctgacctggg ccagccactg      840

gcggtcatgg ttgctggtgg gggcgattag ctgtgtagac ccacaggtgc gtgggcctgg      900

gccgccggcg cctcctcccc aacgcgggga gcctgcccag ttcttctgga gcctgaaatg      960

cgtgcccctc ttggttgccc gctctccaca gtggggaggg ctcacgagga ctaggtgaca     1020

caagcgagcc cctcctggca tccgcgccac aacacttccg gaaggttctg ctgtggaagg     1080

tgcacccgcg ctgctccctc agtctcgggc ccatctctcc aggggtggcc gggtcagctt     1140

agtgcttctc aactttaact ccctaatgag cagcctgggg gtgctgttga cttgcagggc     1200

ctgaggttct gtacgtctaa ccagctccca gcccaggccc gagctccgaa gccccaactg     1260

cactttgagg agcgagaacc ccagctctga tctgccttgc agtgggaggt agagctcgtc     1320

actgcctctc tgggcctcag tttccctctc tggaaaatca gctctggcag ctcttggagg     1380

ccctccccag ctctgacaat ctggaactgc tgccactgct ggtcccctgc cccaggcaca     1440

gcagtgcctt ccctgcgggg agccagcgcc caggtccaac cgggagaggg tctgcctgat     1500

actggctttc cagttctccc tctcacaggc agcctggcca gtgcctgcgg ggcttttaaa     1560

ttctcttcct gcctgggtgg aaggtgggaa accacagcag tgaggcagga agagccttgg     1620

aatgttcctg gttgacagat gggaaaactg acctgcccag gacgccctgg gaacaggggg     1680

cggagctccg gctagagggg actcctgtgt gggcgggcag gtctggagcc tgggcccagg     1740

tgtggcctgc tgggggacag ctccggggga gagctgtggg gagaacagcg gtctagggag     1800

gcaggaggca ggcggcaggc tcctccccag cagcctgcag ggcatcagga cagaggggga     1860

aggaggagac agaagggaaa gaaggagata gagggggaag gaggaaacag cgcggcttct     1920

gctgaagcca gtacaagcct ggttatctgg cttgacccgc ccacacggag gcctccccag     1980

cgttttcttt ttcccgagaa gagctccagc tcgcaggtcc ttagaacaca gcagagcagg     2040

agcatctcag gaaccaacgg ccagctcctt ggcgctgtcc ccagccccac aggcctgctg     2100

cggccatccg caaacgggca tttccttgaa cttttgagag tgcctttgac cagctgttcg     2160

cagctgggaa actccaactt ttgaagtcag agcttggagc ggcccccgca agggcgtggc     2220

tcaaaccctc cccagagctg ggagccattg cttatgcaag cccgtttctt ttgatgtaaa     2280

gatggaagtc gttactatat tttaataatg caaatacatc ttttaaaata agttaacatt     2340

tcttaccacc agatggatca ggctttgaat ttaaacatgt aaatgtttgt aattttatgt     2400

cattttgtta aaatgggacg ctttcaattg gtttccaaga aagatgatac ctctgcattt     2460

tctggtggaa aaggtgtaat acccttaatg agatcaaagt gttaggggaa aaaaattcca     2520

aaagtagtta caagctatat caatgtcaaa gtaaatgcac ttcatcaaag ctaagaagtc     2580

acaggaattg ttctcaggtt tttaaaaaaa tttttcctga attcaggaag tgtcttctga     2640

atagcagcta gccaaataaa gcggtgtgtg tgtactgcag ctgtaggtga acttaaaaat     2700

aataataaaa agaacaaata aagcagtgtg taccagcc                             2738


<210> 2145
<211> 2216
<212> DNA
<213> Homo sapiens

<400> 2145
aaaagcgggc ggcgggccgc attgtctgac ggcgctccct ctctgctttt tgttctcgcc       60

tcgccgcccc gcccctccgc agctctcgag gctcctcccg ctgcgggtcg gcgctcgccc      120

tcgctctcct cgccctccgc cccggccccg gccccgcgcc cgccatggag aagactgagc      180

tgatccagaa ggccaagctg gccgagcagg ccgagcgcta cgacgacatg gccacctgca      240

tgaaggcagt gaccgagcag ggcgccgagc tgtccaacga ggagcgcaac ctgctctccg      300

tggcctacaa gaacgtggtc gggggccgca ggtccgcctg gagggtcatc tctagcatcg      360

agcagaagac cgacacctcc gacaagaagt tgcagctgat taaggactat cgggagaaag      420

tggagtccga gctgagatcc atctgcacca cggtgctgga attgttggat aaatatttaa      480

tagccaatgc aactaatcca gagagtaagg tcttctatct gaaaatgaag ggtgattact      540

tccggtacct tgctgaagtt gcgtgtggtg atgatcgaaa acaaacgata gataattccc      600

aaggagctta ccaagaggca tttgatataa gcaagaaaga gatgcaaccc acacacccaa      660

tccgcctggg gcttgctctt aacttttctg tattttacta tgagattctt aataacccag      720

agcttgcctg cacgctggct aaaacggctt ttgatgaggc cattgctgaa cttgatacac      780

tgaatgaaga ctcatacaaa gacagcaccc tcatcatgca gttgcttaga gacaacctaa      840

cactttggac atcagacagt gcaggagaag aatgtgatgc ggcagaaggg gctgaaaact      900

aaatccatac agggtgtcat ccttctttcc ttcaagaaac ctttttacac atctccattc      960

cttattccac ttggatttcc tatagcaaag aaacccattc atgtgtatgg aatcaactgt     1020

ttatagtctt ttcacactgc agctttggga aaacttcatt ccttgatttg tgtttgtctt     1080

ggccttcctg gtgtgcagta ctgctgtaga aaagtattaa tagcttcatt tcatataaac     1140

ataagtaact cccaaacact tatgtagagg actaaaaatg tatctggtat ttaagtaatc     1200

tgaaccagtt ctgcaagtga ctgtgttttg tattactgtg aaaataagaa aatgtagtta     1260

attacaattt aaagagtatt ccacataact tcttaatttc tacattccct cccttactct     1320

tcgggggttt cctttcagta agcaactttt ccatgctctt aatgtattcc tttttagtag     1380

gaatccggaa gtattagatt gaatggaaaa gcacttgcca tctctgtcta ggggtcacaa     1440

attgaaatgg ctcctgtatc acatacggag gtcttgtgta tctgtggcaa cagggagttt     1500

ccttattcac tctttatttg ctgctgttta agttgccaac ctcccctccc aataaaaatt     1560

cacttacacc tcctgccttt gtagttctgg tattcacttt actatgtgat agaagtagca     1620

tgttgctgcc agaatacaag cattgctttt ggcaaattaa agtgcatgtc atttcttaat     1680

acactagaaa ggggaaataa attaaagtac acaagtccaa gtctaaaact ttagtacttt     1740

tccatgcaga tttgtgcaca tgtgagaggg tgtccagttt gtctagtgat tgttatttag     1800

agagttggac cactattgtg tgttgctaat cattgactgt agtcccaaaa aagccttgtg     1860

aaaatgttat gccctatgta acagcagagt aacataaaat aaaagtacat tttataaacc     1920

atttactatg gctttgtaac aattgcatac ccatatttta agggacaggt gaatttacta     1980

ctttctaaag tttattgata cttccctttt atgtaaaatg tagtagtgat acctatattt     2040

ccacattgtg cattgtgaca cacttgtcta gggatgcctg gaagtgtata aaattggact     2100

gcatttctta gagtgtttta ctatagatca gtctcatggg ccatctcttc ctcagatgta     2160

aatgatatct ggttaagtgt tatatggaat aaagtggaca ttttaaaact agcaaa         2216


<210> 2146
<211> 3502
<212> DNA
<213> Homo sapiens

<400> 2146
tttcttccgc cgtccgccgg tggcgaggcc caggctgtcg ccgggtgtgc agcggcgtcg       60

cggccagtag agggattctg ggtaacggcc cggacccccg gctgggcttc tggctcggcg      120

cagcaggttc cattcacgcc aagtctgttg gcagtggcag ttgtagggcc aagggcggtt      180

gtaggacccg gagcagccgg acatggaaca accgtggccg cctccgggac cctggagcct      240

ccctcgggcc gagggtgagg ctgaggaaga gagtgacttc gacgtgttcc ccagttctcc      300

ccgctgcccg cagctgccag gcggcggcgc ccagatgtat agccatggaa ttgaattggc      360

ttgccaaaag cagaaagagt ttgtgaagag ctctgtggcg tgcaaatgga atcttgctga      420

agctcaacag aaacttggta gcttagcact gcataattct gagtccttgg atcaggagca      480

tgccaaagca caaacagcag tatcagaact gaggcaacgg gaagaagagt ggcgacagaa      540

agaagaagct ctagtacaaa gagagaagat gtgtctgtgg agcacggatg ccattagcaa      600

ggatgttttt aataagagtt ttattaatca agataaaaga aaagacacag aagatgaaga      660

taaatcagaa tcatttatgc aaaaatatga gcaaaaaatc agacattttg gtatgttgag      720

tcgatgggat gatagccaga gatttttgtc tgaccatcca taccttgtat gtgaagaaac      780

tgctaaatat cttattttat ggtgttttca cctggaagct gagaagaaag gggctttaat      840

ggaacaaata gcacatcaag ctgttgtaat gcagtttatt atggaaatgg ccaaaaactg      900

taatgtggat ccaagagggt gttttcgttt atttttccag aaagccaaag cagaggaaga      960

aggttatttt gaagcattca aaaatgaact tgaagctttc aagtcaagag taagacttta     1020

ttctcaatca caaagttttc aacctatgac agttcagaat catgttcccc attctggtgt     1080

tggatctata ggtttattag aatccttacc acagaatcca gattatcttc agtattctat     1140

cagtacagct ctctgcagct taaactcggt ggtacataaa gaagatgatg aacccaaaat     1200

gatggacact gtataatttg gttaagactg ctgaggccaa gtgctatttt gttacaagaa     1260

aggaagaact tggctatttt cttgacactt ttatgggtgc tgcactttat ttttgttcgg     1320

tttttgatgg gagggaaaga gtactgaaat gttttgtaaa ttttttttaa tgtgctgcta     1380

ggttttttgt tttgttttgt tctgaagaga agagtggtac catatgttgc aggaagtcaa     1440

actggacttt ttgtggctac taaatttgct tttaatctta ttgttctcaa ttttggaatc     1500

aagtatgaaa atctgcacaa atgcaatgtt tacaagaact ggttgattct gggaggcatc     1560

tgctacagtc tctttttata tggatatgta catgtcctat tctacaaaaa tgattaaaga     1620

taaaaacata cttgtatccc actgctactt tagctgtcaa atttggtgtt tcatcacatt     1680

aaaagcaata aatcagtagt tggtaatgta ctttactaaa taagttgggg ggtacaattt     1740

ttaaaagtct taactcttaa atacttgact ttcggcacca tcagttaaat ccttgactat     1800

aatacaaatt tgatatatac attacattta ccctcaaatt attctcaaaa ctatattcct     1860

tagaatttga ttttaccctg ctgactttaa gagttataat aatatcaaat gtgatgagct     1920

aatatagatt ttctttttaa ataagaataa cttcaagctc actctttctt aacatagtct     1980

gggatctctc agggagtaag ttttaaaaga atactaatgg cttgtaagaa caaacaggaa     2040

taataatctg atttttaaat ttgtagttat tttactcatg ttgcctttta atttttgtta     2100

ttttggttta ttttttgatg tagcctttta aaaaaggagt cttaaaaatg attttttttt     2160

taaaggcaag agaaatcttg tagtgctaac tgccttgagc tgccaattac ctatttctga     2220

gaatttggtg actcttattg gtaatgatgg catttacaac atttggcatt tccccttttt     2280

cagctcagtt accatagaat acttccaagc tttactactt cctctgtaag tcatttcagt     2340

tatgccagga tatttgatga ttttgtttat gtagaattag gtaacaaagc caattatgct     2400

atccttatta ttgaaggatt aatcttatga cttaacataa gctttggtta tatttgggtg     2460

tagtctttgg ctaagtaccc attaaggcta gtagcaaaca cttggaaggt ggctaactgg     2520

gactgggaat acgtgtctca acttgagaaa ccaaatagtg cgaagggact cagggtggcc     2580

agacctgtga ccttggcctc atttgtatct tgttttcgct gaggtgatca gacacttagt     2640

accctagaaa tggactggaa ttattgaatc ttcttctgta acatcacaat cttcctggtt     2700

ttcagaataa acgtttttgt gcttttgata taaatatata ctctataata aaatgtttga     2760

ctaatttata tagtagtgtt tgtcagcctg tacttttttt ttttttaaac ccatgaccta     2820

gtcgtagaca tttttttctt tttgttctgt tctgaagcaa gctcttattt ttccctttct     2880

accaaattga gagaatgggc agacacagga gccatattcc tagtttcaca gaaatgttac     2940

ttgaattatt attttccctt ctttcccagg atttgcctgt aagcattcaa attgttttga     3000

atttcatttt gccttctcta agttagaggt atttaatgac tgaagactgg caggagagaa     3060

agtatcaaca aactgagtaa actattcttg aggggcactg aaaagatgtt ctttgaaact     3120

tgatttatat atttttactt gcaaaagaat atactgtgtt ttgagtatga aagtgtgatt     3180

gggtctgttg tgggaaccac tgactgatgc cataatttgc acttaaaggc tataaattac     3240

atagttagcc gtactttagt actagaaaca gtaaattgac atccttgaac taattcctac     3300

cttttttttg tttctgaaga aataaagagt atattaagca aagggataat ttatatttca     3360

ggttggacaa tttaccctaa acaaattaaa ccatggaaag tgcaaacaca tgaatgaaac     3420

atttttttac atcaaagtat catcaaagat tcttgtttca tttgataaaa ttaatatttg     3480

aataaaaaaa tttttaaatc aa                                              3502


<210> 2147
<211> 1244
<212> DNA
<213> Homo sapiens

<400> 2147
ccgactattt cttccgccgt ccgccggtgg cgaggcccag gctgtcgccg ggtgtgcagc       60

ggcgtcgcgg ccagtagagg gattctgggt aacggcccgg acccccggct gggcttctgg      120

ctcggcgcag caggttccat tcacgccaag tctgttggca gtggcagttg tagggccaag      180

ggcggttgta ggacccggag cagccggaca tggaacaacc gtggccgcct ccgggaccct      240

ggagcctccc tcgggccgag ggtgaggctg aggaagagag tgacttcgac gtgttcccca      300

gttctccccg ctgcccgcag ctgccaggcg gcggcgccca gatgtatagc catggaattg      360

aattggcttg ccaaaagcag aaagagtttg tgaagagctc tgtggcgtgc aaatggaatc      420

ttgctgaagc tcaacagaaa cttggtagct tagcactgca taattctgag tccttggatc      480

aggagcatgc caaagcacaa acagcagtat cagaactgag gcaacgggaa gaagagtggc      540

gacagaaaga agaagctcta gtacaaagag agaagatgtg tctgtggagc acggatgcca      600

ttagcaagga tgtttttaat aagagtttta ttaatcaaga taaaagaaaa gacacagaag      660

atgaagataa atcagaatca tttatgcaaa aatatgagca aaaaatcaga cattttggta      720

tgttgagtcg atgggatgat agccagagat ttttgtctga ccatccatac cttgtatgtg      780

aagaaactgc taaatatctt attttatggt gttttcacct ggaagctgag aagaaagggg      840

ctttaatgga acaaatagca catcaagctg ttgtaatgca gtttattatg gaaatggcca      900

aaaactgtaa tgtggatcca agagggtgtt ttcgtttatt tttccagaaa gccaaagcag      960

aggaagaagg ttattttgaa gcattcaaaa atgaacttga agctttcaag tcaagagtaa     1020

gactttattc tcaatcacaa agttttcaac ctatgacagt tcagaatcat gttccccatt     1080

ctggtgttgg atctataggt ttattagaat ccttaccaca ggctccaaga ttttaagacc     1140

agctttagcc agtttaatct gttgtctaca ttgtgagaag gaaagtctta ttcaaaagac     1200

aatgtgagga gagtcctata tttagtttta aacctcataa agtg                      1244


<210> 2148
<211> 5638
<212> DNA
<213> Homo sapiens

<400> 2148
accgcaaaga agtcgcgctt tgattgggcc gctgtcaggt gtcgctgcct gcaggttcgg       60

ctgcgcgagc ggagggaggc ggttccctct tatgcttttc atctccatcc ccagccccac      120

ccacagccag ggggcttggg ttctgagctg atggggtacc cccctctgca gagcgggatg      180

agtgggtgtt ccggcaggga tgtggtcatt gacggccagt gagggcgaga gtaccacggc      240

ccacttcttc cttggagctg gagatgaggg gctgggcacc cgtggaatag gcatgaggcc      300

agaagagagt gacagcgagc tccttgagga tgaggaggat gaagtgcctc ctgaacctca      360

gatcattgtt ggcatctgtg ccatgaccaa gaaatccaag tccaagccaa tgactcaaat      420

cctagagcga ctctgcagat ttgactacct gactgttgtc attctgggag aagatgtaat      480

ccttaatgaa cctgtggaaa actggccatc ctgccactgc ctcatctctt tccactccaa      540

aggctttcct ctggacaaag ctgttgctta ctccaagctt cgaaacccct ttcttatcaa      600

tgatctggcc atgcagtatt acatccaaga taggagggag gtgtaccgga tcctgcagga      660

agagggtatt gatctgcctc gatatgctgt gctcaaccgt gatcctgccc ggcctgagga      720

atgcaacctg atagaaggtg aagaccaagt agaggtcaat ggagctgtct ttcccaagcc      780

ctttgtggag aagccagtga gtgcagaaga ccacaatgtt tacatctact accccagctc      840

agctggagga ggaagccagc gtctctttcg taagattggc agccgaagca gtgtttactc      900

tcctgagagc agcgtccgaa agacggggtc gtacatctat gaggagttta tgccaacaga      960

tggcacagat gtcaaggtgt atacagtggg gccagattat gcccatgctg aagctagaaa     1020

atctccagct ttggatggga aggttgaacg agacagtgag gggaaagaga ttcgatatcc     1080

agtcatgctg actgccatgg aaaagctggt ggccaggaaa gtctgcgtag ctttcaagca     1140

aacagtttgt ggatttgacc ttcttcgtgc caatggtcat tcctttgtgt gtgatgtcaa     1200

tggctttagt tttgtcaaga actcgatgaa atactacgat gactgtgcca agattctggg     1260

gaacaccata atgcgggagc ttgccccaca gttccagatt ccatggtcca tccccacgga     1320

ggctgaggac attcccattg ttcccaccac atctggcact atgatggaac ttcgttgtgt     1380

cattgcaatt attcgtcatg gggatcgtac tcccaagcag aagatgaaga tggaagtgaa     1440

acacccaagg ttttttgctc tgtttgaaaa acatggtggc tacaagacag ggaaattaaa     1500

actcaagcga cctgagcagc tccaggaggt gctggatatc acaaggctgt tgttggctga     1560

actggagaaa gaaccaggtg gtgagatcga ggagaagact ggaaaactag agcagctgaa     1620

gtctgtactg gagatgtatg gtcacttctc aggtataaac cggaaggtac aattgactta     1680

ctaccctcat ggagtaaaag cttctaatga ggggcaagat ccacagaggg aaactctggc     1740

cccatctctg ttgctggtac tgaagtgggg tggagaactg actcctgctg gccgtgttca     1800

ggctgaggag ctggggcgag cttttcgctg catgtaccct ggaggacagg gtgactatgc     1860

tggcttccct ggttgtgggc tgcttcgtct ccatagcact ttccgccacg atctcaagat     1920

ctatgcctct gatgagggtc gtgttcagat gactgctgct gccttcgcca agggccttct     1980

ggctctagaa ggggagctga cacccatttt ggtgcaaatg gtgaagagtg ccaacatgaa     2040

tgggctactg gacagcgatg gggattcctt gagcagctgc cagcaccggg tgaaggctcg     2100

gctgcaccat attctacagc aggatgcgcc ctttggccct gaggactacg atcagctggc     2160

tcccaccaga agtacttccc tgctcaactc catgactatc atccagaatc ctgtgaaggt     2220

ctgtgatcag gtatttgccc tgatcgaaaa cctcacccac cagatccggg aacgaatgca     2280

ggaccccagg tctgtagacc tgcagctcta ccacagtgag acactagagc taatgctaca     2340

gcgttggagc aagctggagc gtgactttcg acagaagagt gggcgctatg atatcagtaa     2400

gatccctgac atctatgact gtgtcaagta tgatgtgcag cacaatggga gtctgggact     2460

tcaaggcaca gcagagttgc tccgtctctc taaggcactg gctgatgtgg tcattcccca     2520

ggagtacggg atcagtcggg aggagaaact ggaaattgct gtgggcttct gtcttccact     2580

gttgcggaag atactacttg acctgcagag aacccacgag gatgagtctg tcaacaagct     2640

gcatcccctg tactcccgag gcgtgctctc cccaggtcgc cacgttcgaa cgcgtctcta     2700

tttcaccagt gagagccatg tccactccct gctcagtgtc ttccgttatg gaggacttct     2760

tgatgagacc caggatgcac aatggcagcg agctttggat tatcttagtg ccatctcaga     2820

gcttaactac atgacccaga ttgtcatcat gctttatgag gacaacacac aggatccctt     2880

atcagaggaa cggttccatg tggagctaca cttcagcccc ggagtgaaag gtgttgagga     2940

agaaggcagt gccccggctg gctgtggatt ccgtccagcc tcttctgaga atgaggagat     3000

gaaaaccaac caaggcagta tggagaacct gtgtccagga aaggcatcag atgaaccaga     3060

ccgggcattg cagacttcac cccagcctcc tgagggccct ggccttccga ggagatcacc     3120

cctcattcgt aaccgaaaag ctggttccat ggaggtactt tctgagactt catcctcgag     3180

gcctggtggc taccggctct tttcatcttc acggccaccc acagaaatga agcagagtgg     3240

cctaggctca cagtgcacag ggctgttcag caccacagtg ctgggtggct cctccagtgc     3300

cccgaatctt caggactacg cccgcagcca tggcaaaaag ctaccacctg ccagtctgaa     3360

gcaccgagat gggtttgaag ggtgttccat ggtgcctacc atctaccctc tggaaacact     3420

gcataatgcc ctttccctac gtcaagtgag tgaattcttg agtagagtct gccagcgcca     3480

cactgatgcc caggcacagg catctgcagc cctctttgat tccatgcaca gcagccaggc     3540

ctcagataac ccattttctc caccacgtac tcttcattca cctcccctgc aactccagca     3600

gcgctctgag aagccccctt ggtacagcag tggcccttct agcactgtgt ccagtgctgg     3660

tccttcttcc cctactacag tagatggtaa ctcccaattt ggcttcagtg atcaaccctc     3720

cctaaattca cacgtggctg aagaacatca aggccttggg ctgctccagg agacccctgg     3780

gagtggagca caagagctct ccatagaagg ggagcaagag ctttttgaac caaatcagtc     3840

cccacaggtg ccacctatgg aaaccagcca gccatacgag gaggtcagcc agccatgtca     3900

ggaggtccct gacatcagcc agccatgcca ggacatttct gaggcgctca gccagccatg     3960

tcagaaggtc cctgacatca gccagcaatg ccaggagaac catgacaatg gtaaccacac     4020

atgccaggag gtccctcaca tcagccagcc atgccagaag tccagccaac tgtgccagaa     4080

agtctctgag gaagtttgcc agctatgtct ggagaactcc gaggaggtca gccagccatg     4140

ccagggggtc tctgtggagg ttggcaagct ggtccataag ttccatgtag gggttggtag     4200

cttggtccag gaaacccttg tagaagttgg cagcccagct gaagagatcc ctgaggaggt     4260

catccagcca taccaggagt tctctgtgga ggttggcagg ctggcccagg agacttctgc     4320

gatcaatctg ttatctcagg gcatccctga gattgataaa ccatcccaag agttccctga     4380

ggagattgat ctgcaggccc aggaggtccc tgaggagata aattagaagt cctgggtggt     4440

ccctgaagtg attgatcagc tgcctggaga gggtattcct caagcccagc atccatctgg     4500

tgatccaaac cctcagagcc agtctctagc ccatgaccag cactcacccc ttccaccagc     4560

aacatgtgat taattttctc attagtggta tcacactata ccagccattt gagccagcaa     4620

ccttttctgt tggctaactc actggccagc tctcaccagc ggtgtctggg gaagtagttc     4680

tctttgtatg aagcatacct gtgccagagc tgtggttgag gaggagccag ttttaggttc     4740

gaagaagcca ttggctcctc acttagccat tagacttgaa taggatttcc ttggggtggg     4800

ttggtctgtc attacccagc cttctctgag catcctagga aatcacagat tgttaaagga     4860

aatgccgctt cactgctgaa gacaccatct ggcgacagca aatgcaaaag aggggactct     4920

agggtcttca cttttctggg gaaatgttca cgacttctca aggtacgctt agaccatatg     4980

tgcattcagg ggactcttgt ctttgccagc actcctcagg tgagcccggg atggctatct     5040

gaaatgtctg gaaaatagag tcccttcccc aaacatctga catggccact aaatctttag     5100

acttgcctta tagatccttc catatcatcc ccaagtgccc cttctgcctc agtcctgttc     5160

ctctgggcaa tagctctagg gaaaagtagg tattagactg ctgtgcaaaa ttcagagcaa     5220

ctacttaaaa tgctctagag gattcttagc cagtctgtga aagtgggcct cctctgtggt     5280

ggggctgttt ggcttaggag atgctgtagt agtagagata atcaggttct attttaagca     5340

atcagcagag atcaatattg tacagataca agcaaaggtt taataaatat atatatatat     5400

atttatttct gtagttgtgc cagggacaga ctggccaaag accaaacact gcagggtccc     5460

caagaaattt gtccttatat cattgtgtct gagggccaga tatgattatg aagctttttc     5520

caaagatcca gggatgggaa tgggagtggg taggaggggt aatgcggtca ttggagtcgg     5580

gggctggaac attatgagtg ctcaataaat ataaactaat gagaatggtg gtgatgga       5638


<210> 2149
<211> 921
<212> DNA
<213> Homo sapiens

<400> 2149
agccaagttc tttccatcat cctgggccct cacctctggc ataggctctt ggtagtgggg       60

gcccagacag ggaggcacct gccacctgct tcccttctca gccacccaca gccctcatag      120

ggcagaatgg gactcttgct gatgtagccg ggtcccaatg ataagaagtc agaactgctg      180

ccagctgggt ggaacaacaa taaagacctg tatgtcctcc ggtatgagta taaggatggg      240

tccagaaagc tccttgtgaa agccatcacc gtggagagca gcatgatcct caatgtgctg      300

gaatatggct cacagcaagt ggcagacttg accctgaact tggatgatta tatcgatgca      360

gaacacctgg gtgacttcca caggacctac aagaacagtg aggagcttcg gtctcgtatt      420

gtgtctggaa tcatcacacc tatccatgag cagtgggaaa aggctaatgt aagcagtccc      480

caccgggagt tcccccctgc taccgccaga gaggtggacc cactccggat tcctccacac      540

cacccacaca ccagtcggca gcctccctgg tgtgatcccc tgggcccgtt tgttgtcggg      600

ggagaagact tagacccttt tgggcctcgg agaggtggca tgattgtgga tcccctgaga      660

tctggcttcc caagagcact tattgaccct tcctcaggcc tcccgaaccg acttcctcca      720

ggcgctgtgc ccccaggagc tcgctttgac ccctttggac ccattgggac cagcccaccc      780

ggcccgaggc ctgacagacg cgggcagtga tgagccctgt tctggagtgg aaagagcacg      840

atagagcacc aggctaagag gcacgagatc aaggcggtag tcacttccgc tctgcagcta      900

gcatttcaac catatgtgga t                                                921


<210> 2150
<211> 704
<212> DNA
<213> Homo sapiens

<400> 2150
atcatcctgg gccctcacct ctggcatagg ctcttggtag tgggggccca gacagggagg       60

cacctgccac ctgcttccct tctcagccac ccacagccct catagggcag aatgggactc      120

ttgctgatgt agacgccgaa gtcgcgggcg ctcatggcgg gcctggaggt actgttcgca      180

tcggcagcgc cggccatcac ctgcaggcag gacgcgctcg tctgcttctt gcattgggaa      240

gtggtgacac acggttactt cggcttgggt gtcggtgacc agccgggtcc caatgataag      300

aagtcagaac tgctgccagc tgggtggaac aacaataaag acctgtatgt cctccggtat      360

gagtataagg atgggtccag aaagctcctt gtgaaagcca tcaccgtgga gagcagcatg      420

atcctcaatg tgctggaata tggctcacag caagtggcag acttgaccct gaacttggat      480

gattatatcg atgcagaaca cctgggtgac ttccacagga cctacaagaa cagtgaggag      540

cttcggtctc gtattgtgtc tggaatcatc acacctatcc atgagcagtg ggaaaaggct      600

aatgtaagca gtccccaccg ggagttcccc cctgctaccg ccagagaggt ggacccactc      660

cggattcctc cacaccaccc acacaccagt cggcagcctc cctg                       704


<210> 2151
<211> 1737
<212> DNA
<213> Homo sapiens

<400> 2151
tcagctcgac cgcggagggc agctccaaag gggaccccaa aggtgcccac gcggggctgg       60

ggcctcctgg gcgtcgttgg gagcggccac taccggcccg ggtccgagct gtcagcctct      120

ccaaagcctg cgcgagagga gccgggacac gcctagcgcg ggctccagtg gccggtgtcc      180

agctgcctac tttctgcccg gatctctggc tcctcatctc tccggtctcc gcagactaaa      240

gccctcggga tatgcagcag ccatgcctgt gcacacgctg agccccggag ccccgtccgc      300

ccccgcccta ccttgccgcc tgcggaccag ggtccctggc tacctgctac gggggccggc      360

agatggtgga gcccggaaac cgagcgctgt ggagcgcctg gaggccgaca aggccaagta      420

cgtcaagagc ctgcacgtgg ccaacacccg ccaggagcct gtgcagcccc tgctgtccaa      480

acagccgctc tttagccctg agactcgccg cacagtgctc acgcccagcc gccgagccct      540

gcctggcccc tgccgacggc cccagctgga cctggacatc ctcagcagcc tcatcgactt      600

gtgtgacagc cccgtgtccc ctgccgaggc cagccgcact cctggacggg ccgagggagc      660

cggccgtcct cccccagcca cccctccgcg accgccgccc agtacctctg cggtccgccg      720

ggtggacgtc cgccccctgc ccgcctcgcc tgcccggccc tgcccatcac ccggccctgc      780

cgccgcctcc agcccagccc ggccgccggg tttgcaacgc tccaagtcgg acttgagcga      840

gcgcttttct agggcagccg ctgatctcga gcgctttttt aacttctgcg gcctggaccc      900

ggaggaggcg agagggttgg gtgtggccca cctggcacgg gccagctcgg atatcgtgtc      960

cctggcaggg cccagtgctg ggccgggcag ctctgaaggg ggctgctccc gccgcagctc     1020

ggtgactgtt gaggagcggg cccgggagcg cgttccctat ggcgtgtcgg tggtggagcg     1080

caatgcccgc gtgatcaagt ggttgtatgg gctaaggcag gctcgggaga gcccagcagc     1140

tgaaggctag gcgccactgg gcctggaatt cgccacagga cggatcttac agaggcaagt     1200

ggtccctgga cctctcttgc atccattctc tagacggccg tgtcagaggc tccaccctgt     1260

tgtgaacttg gtatggaggc aaaggcttag aggctggacc agcattgttg ggcaaggact     1320

gactctccaa gggttttgtt cttggctttg gacacctgag aaccccctcc tcccctcccc     1380

caatacaagg tttttgacat gagtgtactc ctgcttagtt cctcttgtgg ggctgcattt     1440

gcggtgcttt gccctcccca ctgtgagtga ggggccaagg gatctcctca atcctgtctc     1500

cccagcggct ctgtttcctc cttccttcct tggcctctgt cctttgctga cttcctcttc     1560

cttacccagc agaactcacc ctggggtcgg ggcagtgggg aggggcctat ccactgctct     1620

tcctagtcct tggcagctgg cctaggtggg cagactatag gagggactgg ttaggagtct     1680

gcattgcttt gacttccctc tccttggtta ataaacacaa atgcttgttt ctcaagg        1737


<210> 2152
<211> 1809
<212> DNA
<213> Homo sapiens

<400> 2152
acttcccctt ccacggcgcc ccagggactt tccctgcggt gggggccttc gacagtgagg       60

gccacccgct cagctcgacc gcggagggca gctccaaagg ggaccccaaa ggtgcccacg      120

cggggctggg gcctcctggg cgtcgttggg agcggccact accggcccgg gtccgagctg      180

tcagcctctc caaagcctgc gcgagaggag ccgggacacg cctagcgcgg gctccagcag      240

tggccggtgt ccagctgcct actttctgcc cggatctctg gctcctcatc tctccggtct      300

ccgcagacta aagccctcgg gatatgcagc agccatgcct gtgcacacgc tgagccccgg      360

agccccgtcc gcccccgccc taccttgccg cctgcggacc agggtccctg gctacctgct      420

acgggggccg gcagatggtg gagcccggaa accgagcgct gtggagcgcc tggaggccga      480

caaggccaag tacgtcaaga gcctgcacgt ggccaacacc cgccaggagc ctgtgcagcc      540

cctgctgtcc aaacagccgc tctttagccc tgagactcgc cgcacagtgc tcacgcccag      600

ccgccgagcc ctgcctggcc cctgccgacg gccccagctg gacctggaca tcctcagcag      660

cctcatcgac ttgtgtgaca gccccgtgtc ccctgccgag gccagccgca ctcctggacg      720

ggccgaggga gccggccgtc ctcccccagc cacccctccg cgaccgccgc ccagtacctc      780

tgcggtccgc cgggtggacg tccgccccct gcccgcctcg cctgcccggc cctgcccatc      840

acccggccct gccgccgcct ccagcccagc ccggccgccg ggtttgcaac gctccaagtc      900

ggacttgagc gagcgctttt ctagggcagc cgctgatctc gagcgctttt ttaacttctg      960

cggcctggac ccggaggagg cgagagggtt gggtgtggcc cacctggcac gggccagctc     1020

ggatatcgtg tccctggcag ggcccagtgc tgggccgggc agctctgaag ggggctgctc     1080

ccgccgcagc tcggtgactg ttgaggagcg ggcccgggag cgcgttccct atggcgtgtc     1140

ggtggtggag cgcaatgccc gcgtgatcaa gtggttgtat gggctaaggc aggctcggga     1200

gagcccagca gctgaaggct aggcgccact gggcctggaa ttcgccacag gacggatctt     1260

acagaggcaa gtggtccctg gacctctctt gcatccattc tctagacggc cgtgtcagag     1320

gctccaccct gttgtgaact tggtatggag gcaaaggctt agaggctgga ccagcattgt     1380

tgggcaagga ctgactctcc aagggttttg ttcttggctt tggacacctg agaaccccct     1440

cctcccctcc cccaatacaa ggtttttgac atgagtgtac tcctgcttag ttcctcttgt     1500

ggggctgcat ttgcggtgct ttgccctccc cactgtgagt gaggggccaa gggatctcct     1560

caatcctgtc tccccagcgg ctctgtttcc tccttccttc cttggcctct gtcctttgct     1620

gacttcctct tccttaccca gcagaactca ccctggggtc ggggcagtgg ggaggggcct     1680

atccactgct cttcctagtc cttggcagct ggcctaggtg ggcagactat aggagggact     1740

ggttaggagt ctgcattgct ttgacttccc tctccttggt taataaacac aaatgcttgt     1800

ttctcaagg                                                             1809


<210> 2153
<211> 2698
<212> DNA
<213> Homo sapiens

<400> 2153
cggcacctgg cgagcggagc cggagtcggg ctggggaccg cggggtcgag gccggaccgc       60

ggcggggtcg ggggagaaac gcgcgctgcc ctggcacggg cccccccccc cggccgcgcg      120

gaatggtatg gcccggccgg agttaaggcc ggggggaggc ggcgagtccc gcggcggcgg      180

cgacgatggg gctgcgtgca ggaggaacgc tgggcagggc cggcgcgggt cggggggcgc      240

ccgaggggcc cgggccgagc ggcggcgcgc agggcggcag catccactcg ggccgcatcg      300

ccgcggtgca caacgtgccg ctgagcgtgc tcatccggcc gctgccgtcc gtgttggacc      360

ccgccaaggt gcagagcctc gtggacacga tccgggagga cccagacagc gtgcccccca      420

tcgatgtcct ctggatcaaa ggggcccagg gaggtgacta cttctactcc tttgggggct      480

gccaccgcta cgcggcctac cagcaactgc agcgagagac catccccgcc aagcttgtcc      540

agtccactct ctcagaccta agggtgtacc tgggagcatc cacaccagac ttgcagtagc      600

agcctccttg gcacctgctg ccaccttcaa gagcccagaa gacacacctg gcctccagca      660

ggctgggcca tgcagaaggg atagcagggg tgcattctct ttgcacctgg cgagagggtc      720

tgactctggg cacccctctc accagctaca aggccttgga ctcactgtac agtgtgggag      780

ccccagttcc cacctctgtg acaataggat catggcctta cccttgaagc attaccgaga      840

aggagaacag agatgggctt gaagagccac gtgctgccgg ctccaaattc ccaaggacaa      900

ggatccctct gcatttttgt ctatgtaacc tcttatatgg actacattca gctgcaagga      960

aaggaaaacc ttgattgcag tggtttaaac aaacagaaga ttgtttttcc acatagcatg     1020

gattctggag atgggtggct aatggtattg gttcaacaac tccacgaagg taggggtcac     1080

gtcttggatc cttttgcctt aatctcagtg ctcgttactt catggtccca agatggctgc     1140

tgtatcccca agaatcatgt ctgcgttcaa ggaaggaggg gtggaggaag aggaagggcc     1200

aaactagctg gacccgtcac cttctatcag aaagtaaaac ctcgtcagaa gtctgtttcc     1260

tgctctctcc ctctgcatat cttcacttag atgcccttgg cccgagccag ctaccattgc     1320

acctctagct gcaaacaaag ctaagacagc agggaacaga attgtcatgg ctgaatagac     1380

caatcgtgtt ccatctactg agactggcac actgcctcct gcaataaaac tgggatccca     1440

ttaccaagag agaaatgcag aattgtgtac cagttagctt ttgctgtgta acaaaccatc     1500

cccaaacttg gcagctagaa acaaaccctg tattttccca caatcctatg ggttggcaat     1560

ttgggctggg ctcaacaggg cagttctgct gctcacacct gggatccctc atggagctaa     1620

ggtcagctgt tacctcagct gggcctggat ggtctaggat agccttactc acttgcctgg     1680

caggtgacag gctgttggct ggaattgctt ggttctcctc catgtggcct ctccagcagg     1740

ctagctcagg cttattcaca tgatggcttc aggattccaa agagagtgag agtagaagct     1800

gaaagacttc ttgagttctt ggcctggaac tgggactagg acagtgtcac ttctgctaag     1860

ttcttttggt cagagcaaat cacaaggctt tacccagatt caagggatga gaaacagact     1920

acatgtcttg atgaggggaa ccacaaagag cttgtggcca tttttcacct atcacaaata     1980

attttggatg ggtatttatt tggataaagg tatttccctc ttcccccttt ctctctgtct     2040

catggggcct cactctgcca agttggaagg cactaagaca ttgtcctggc cctcagggtc     2100

taggggaaga ggtgttgggg caggaagtga gtctctccat gggctggacc cactgtagta     2160

ggagtgcctc cttgtctgca ctgctggtat ggggttaggc caggtaggac attccagagg     2220

ggcttctgaa aaccaagagt ccctggggaa agggaacaga gtaaggcagg ccttgttctc     2280

actgccctct aagggaactt ggtcactcgg cacttttaag cctcagtttc tccagttcaa     2340

taataaggac aagagctttt cccatgcatt ctctttcccc gggaaagttg actgaggtga     2400

ccagtaatag aattgaaaag ggagagtgtc ttcagtgcaa tgtggcatcc tggattgggt     2460

cttggaacaa aaacaggaca ttagtgggaa aattggaaat ctgaaaaaag tctgaatttt     2520

agttaatata ccaatttcag tctcttggtt ttgacagatg taccatggtg atgtaagatg     2580

ttgaccttgg ggtaggctgg gtgaagggta tacaggaact ctttgtacta tctctgcaac     2640

ttctctgtaa atctagtatc attccaaaat aaaagtttat ttaatttaaa aaaaaaaa       2698


<210> 2154
<211> 6208
<212> DNA
<213> Homo sapiens

<400> 2154
gcgctcccgc ttgccgcagc ctgcgtcgtc tgccgccacc gcgcgccttc actgacctac       60

accaccgccg ccgccgccgc cgccgccggg ctcgctggct ggcccggtgc gggcggcgga      120

ctcccgccgg agaggactgc cagcgccgcc gccgccgccg cttcggcccg ggcccgggcc      180

ccgaccccgt cccgggcccc agcgccggcc gcccgcccgg tcgggcgatg aagtgtcact      240

atgaggcgct gggggtgcgg cgcgacgcca gcgaggagga gctcaagaag gcctatcgga      300

agctggccct gaaatggcac ccggataaaa atctggataa tgccgcagaa gcagctgaac      360

aatttaaatt aatccaagca gcatatgatg tgttgagtga ccctcaggaa agagcatggt      420

atgataatca tagagaggcc ctacttaaag gtgggtttga tggcgaatat caagatgaca      480

gcttagattt gctacgctat ttcaccgtta cctgttattc tggttatgga gatgatgaaa      540

agggatttta cacggtgtat cgtaatgttt ttgaaatgat tgccaaggaa gaactagaat      600

ctgtgttaga ggaagaggtt gatgatttcc caacttttgg agactcccag agtgactatg      660

atacggtagt ccatcctttc tacgcttatt ggcagagttt ctgcactcaa aagaattttg      720

catggaagga agaatatgat acacgacagg cttcaaaccg ctgggaaaaa cgagccatgg      780

aaaaagaaaa caaaaagatt cgggacaaag caaggaaaga gaagaatgag cttgtccgtc      840

agctggtagc tttcattcgt aaaagagata aaagagtgca ggcgcatcga aaacttgtgg      900

aagaacagaa tgcagagaag gcgaggaaag ccgaagagat gaggcggcag cagaagctaa      960

agcaggccaa actggtggag cagtacagag aacagagctg gatgactatg gccaatttgg     1020

agaaagagct ccaggagatg gaggcacggt acgagaagga gtttggagat ggatcggatg     1080

aaaatgaaat ggaagaacat gaactcaaag atgaggagga tggtaaagac agtgatgagg     1140

ccgaggacgc tgagctctat gatgaccttt actgcccagc atgtgacaaa tcgttcaaga     1200

cagaaaaggc catgaagaat cacgagaagt caaagaagca tcgggaaatg gtggccttgc     1260

taaaacaaca gctggaggag gaagaagaaa atttttcaag acctcaaatt gatgaaaatc     1320

cattagatga caattctgag gaagaaatgg aagatgcacc aaaacaaaag ctttctaaaa     1380

aacagaagaa aaagaaacag aaaccagcac aggatgtacc tggcaaagat tcatatctgc     1440

ctgcagctca ctttcagatg gcttggggaa aaaagtgtgt gttgggagag agaagagatg     1500

gagagagcga gcacaaatgt gccaaaatgt tgcttgaaaa cagacagaat tatgatgaca     1560

atttcaatgt aaatggacct ggagaaggag taaaggttga tccagaagat actaacttaa     1620

atcaagacag tgccaaagaa ttggaagata gtccccagga aaatgtcagt gtcacagaga     1680

tcattaaacc atgtgatgat ccaaaaagtg aagctaaaag tgttcctaaa cccaaaggaa     1740

agaaaaccaa agatatgaaa aaacctgtca gagtacctgc tgaaccacaa acaatgagtg     1800

ttcttatcag ctgtacaacc tgccatagtg aatttccatc tcggaataaa ctttttgacc     1860

atctaaaggc cacaggtcat gcaagagcac cttcatcatc gtctttaaac agcgcaacaa     1920

gtagtcaaag caagaaagag aaacgtaaaa acagatagag attctgcctg tgcttttgtt     1980

tgactgtctc tagattttga aaccaaaaaa ctgaactgaa atcatctaaa gagttaaaat     2040

ttcagtgatc tgcaattaat tacattgtgg aagattattt tttatcttgt aaaaacactt     2100

ttttggttta atatatattt ttaaaacatt tcactagtga ttgaattcta cttttgccat     2160

ctgaattgac ttgaatgtct taaaacaggt aaatactgta aagtgtgtat tcttgatgtt     2220

tattggctca tgtggacaga aatgtacagg gagaattaca ttattttaac acacagaagt     2280

gcaactttct gctttatttt ctgaatttca cattactttt acttaatgct tttgtgtttt     2340

gttaatactt cataatatgt gaaaaactcg gatcttttaa aaagcatcat agatcatttt     2400

tccatatgac actggttccg attttaaaaa ttatttttaa ataaccgatt attgattact     2460

gtattttttt tctcaagaac agtgataggt agaaactaat tgaacatttg gtagtctttc     2520

aagaatagtg tctcttcaag gttttacttg atttaatttg atattttact ggtttaccag     2580

taaggtgtat tgttcagttt tttgctccga tttgaattgt ggaggtggaa gcaaattagt     2640

ttacatggca tgtcctccct aggcacagtg acagctgtaa agtatgacgg aacaaggtag     2700

cagatggtac agaatttata ctatttaaga agagatgtgg tgttcttcat tgagtttttt     2760

tcttcactat tttcagaagt ttttgttctt tttttttttt ccatcactca gtggagaaaa     2820

gctttgttaa tgaaagattt tgtgatagag ctgatgctta tacatctatt ctataacagt     2880

gatgaatatt aacacaaagg aaatatggag aactgttata actgagtgtt agaacagtcg     2940

tgtacattga tcagtattga gtccattttt aggatggatt agtcagttct tttcattggt     3000

cttgaaagta attttggctg gtcgcggtgg ctcacgcctg taatcccagc actttgggag     3060

gccgaggcgg gcggatcacg aggtcaggag atcgagacca tcccggctaa aacggtgaaa     3120

ccccgtctct actaaaaata caaaaaatta gccgggcgta gtggcgggcg cctgtagtcc     3180

cagctacttg ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgg agcttgcagt     3240

gagccgagat cccgccactg cactccagcc tgggcgacag agcgagactc cgtctcaaaa     3300

aaaaaaaaaa aaaaaaaaag aaagtaattt taaactcact ggcttgaaat gtgtgctttc     3360

tgtacaatga agttattgct ttccatatat ccttgaatct tcagattaac gaaatgaaca     3420

aattttcggt tacagatcag ctctcaaaca ctaaagtcct taatggcaag gtcttttctg     3480

atagcttcat ggatagtatt gatgatcaga tttcttctgt gttattgtct taaaaataag     3540

catttgaacc ttaatttaaa ttcttttctt ttccatttag agatatgttt ttttctttac     3600

cttcatacct ttctatttct tgctaatttc tatcactaat tccttataat tgtccctgct     3660

ccccttcttg atctcttcag ggggaatact aggcagtttt gtatcttctg atctcgtacc     3720

ctgagacttc atctgaatgt gctctgccgc cttcttatct gaactagatg aattggccat     3780

aattatgaat aggaatatta atgaaccaga ggacatacta gtcacatgtt attatacact     3840

aaaaaatagg aagtcatctt gaaaggcagt taatgtactg caaatgtccc tatgacttct     3900

ttgctttctc ttataccaaa catgcaggta tttaatttgt ttaatgaggg ttgagtggag     3960

ttatgtgtcg cttttattcg gattgacgaa aatcaaccat aattttcaag ggatcttcat     4020

gggttgtgac tggaagctga ccttagtctt gcgtctcatc ctttatgatg ttgagaaatc     4080

atctaatttc tcagaacttt ttcttatctc taacacagtt attaccataa taatattgtc     4140

tccatttatc atacaggatc attatgaaag taaaatgaag tagtatatat gaaaatgctt     4200

tttaaacaca aaagctttat acaaaatatt gttgaattta aataaggtaa atctttttta     4260

gtttatatat ttgcagacta tacatgttgg attaaatggg caattaagtt ttataggaat     4320

ttgcttccta agtctacttt tgaagaggaa aacaggaacg taccatatat tttgctaagg     4380

gtaaaatatt tttggtgaat tgcagacatt taatttcact tgtctgaggt aaaacaataa     4440

actaaaatac atgggcatgc atcttacact gatcttatta gaggtcagtg ctaagtaccc     4500

atcttgattg aagttagctc agatgtggag attcatagaa tgagggtcca ggagaagaaa     4560

gttaggggaa atctcatttt ctttctgtaa ttcattcagt ggtgccaaag ctgggggttc     4620

cctacaatgg ctatttagac tttccctgct tcaaaataag agcagtatcc ttagctctag     4680

ccaagcattt ttctaattcc tgcctttggt cacaaagaag gaaaagcaga gctgtgaatg     4740

agttagtgga ggtcaagtca catcagagtt catgacctag tgattgctgg tgaagtaata     4800

ttggaatttt ggtaccatga gaagacttat aaaggatttc atcagaagtt ttcatttttt     4860

ctaaatcctc ccctacaaaa ttttcagatt ggaaattact cttgtatttg tagaagattg     4920

tctctaaaat tgtggtttaa ctcacgcagg aagtaaaatt cctatagcaa gacatagttt     4980

cattttagag gacccccaaa atcccgtgaa ttctctggtg atgattctag cctaaccttc     5040

aacataaaat aatgaagaga acttttaaac ttttttatga attcctaaac attaccattt     5100

atgtggcaga agttctgttc cctataatct gcaatgctga agtatctcta ttcaattccc     5160

ttccttatct gttaaattta atgtctttat actaaaaata taggctcttg ggattggaga     5220

ggaaaaatta gaggtgattt tcagatttct tgttctatgg aagaggaagc tgagctcagg     5280

gagatatgag ctccacagcc acagctggtt aggggcggct gccagtagaa cagggcagat     5340

gcctggactc ccaactcagt aggccttctg ttacacctca aaatgtgtta catgggaaga     5400

aaaagattaa gaaaaagcaa gataattttg aagaaggacg agaggaagag gcatgaactt     5460

gtcctaacaa tgtcaaagaa tattttaaag gtataccagt taaagtagtg tgtggctggt     5520

gccagtagag gtcagtcaag ggatccctga cgagaataaa gagcccagaa acaggtccat     5580

gtttatatgg gaacttgatt tttgacagat acggcaagct ctatggggaa aacaatatgt     5640

actaccttat acccttcccc aaaaacaaag ggattaaaga cctaaatatg aagacaaaac     5700

ttttaaatga gaatctataa ggttattttc atgattttgc aaatgggaag gatttcttta     5760

aagcaagaca caaaagcata cacaggaaaa aatgatgcat aaaaacatgg cttctgtaga     5820

acaatagaga ctgtaaaaga acaagctaca gacaaggaaa tgtttgcaat gcatggaact     5880

gtcaaaggat tcgtatctgg aatacattaa agaagcaaaa gaacctcata caaaagtcat     5940

tgagtaaatg acagccatgc attagaacag caattctcaa aacttttggt ctcaagatcc     6000

ctttacactc ttcaaaagtg agaaccccaa agagttttca tgtatgtggg ttaaatctat     6060

tgatattttc tgttagaatt taaaaattat gttaaaaaaa taagaagaat gactattttt     6120

caaaacaaaa aatgagaaga gtggtattgt tttacatttt tacaaatctc tttaacattt     6180

agcttaataa aagatagctg gcctctca                                        6208


<210> 2155
<211> 2583
<212> DNA
<213> Homo sapiens

<400> 2155
gattcccggg gttggtggca gcggcggtag cagcaatgga ctttctcctg gggaacccgt       60

tcagctctcc agtgggacag cgcatcgaga aagccacaga tggctccctg cagagcgagg      120

actgggccct caacatggag atctgcgaca tcatcaacga gacggaggaa ggtgactctg      180

ctgctggagg tccaggggcc acaggttgtg agtccctgct aagcaatggg ctaggaagat      240

tctgatgtga tcagaacctg gctggataca caaaacagtc ccaaagatgc cctccgagca      300

gtaaagaaga gaatcgtggg gaataagaac ttccacgagg tgatgctggc tctcacagtc      360

ttagaaacct gtgtcaagaa ctgcgggcac cgcttccacg tgctggtggc cagccaggac      420

ttcgtggaga gtgtgctggt gaggaccatc ctgcccaaga acaacccacc caccatcgtg      480

catgacaaag tgctcaacct catccagtcc tgggctgacg cgttccgcag ctcgcccgat      540

ctgacaggtg tggtcaccat ctatgaggac ctgcggagga aaggcctgga gttccccatg      600

actgacctgg acatgctgtc acccatccac acaccccaga ggaccgtgtt caactcagag      660

acacaatcag gacaggattc tgtgggcact gactccagcc agcaagagga ctctggccag      720

catgctgccc ctctgcccgc cccgcccata ctctccggtg acacgcccat agcaccaacc      780

ccggaacaga ttgggaagct gcgcagtgag ctggagatgg tgagtgggaa cgtgagggtg      840

atgtcggaga tgctgacgga gctggtgccc acccaggccg agcccgcaga cctggagctg      900

ctgcaggagc tcaaccgcac gtgccgagcc atgcagcagc gggtcctgga gctcatccct      960

cagatcgcca atgagcagct gacagaggag ctgctcatcg tcaatgacaa tctcaacaat     1020

gtgttcctgc gccatgaacg agacaggggt ctcactgtgt tgcccaggct agtctcaaac     1080

tcttggcctc aagcagtcct ccctccttgg cctccgaaag cattggtatt acaggcatga     1140

gccaccacac ccacctgccc accttgtatc attctgttca agagtcacat ccccaagaga     1200

gacttggatt ggctgagctt cattgtgcct accagctggg gtttgaacgg ttccgaacag     1260

gccagaccac caaggcccca agtgaggccg agccggcagc tgacctgatc gacatgggcc     1320

ctgacccagc agccaccggc aacctctcat cccagctggc aggaatgaac ctgggctcca     1380

gcagtgtgag agctggcctg cagtctctgg aggcctctgg tcgactggaa gatgagtttg     1440

acatgtttgc gctgacacgg ggcagctcac tggctgacca acggaaagag gtaaaatacg     1500

aagcccccca agcaacagac ggcctggctg gagccctgga cgcccggcag cagagcactg     1560

gcgcgatccc agtcacccag gcctgcctca tggaggacat cgagcagtgg ctgtccactg     1620

acgtgggtaa tgatgcggaa gagcctaagg gggtcaccag cgaagaattt gacaaattcc     1680

tggaagaacg ggccaaagcc gcggaccgat tgcccaacct ctccagcccc tcagctgagg     1740

ggcccccggg tcccccatct ggcccagcgc cccggaagaa gacccaggag aaagatgatg     1800

acatgctgtt tgccttatga gtgtggggtc tggcaccctg cagcccaggt ccccactgct     1860

ctcacaccct taggctggga cctccctccc tcctctggtg ttaaggctgc tttgggggtg     1920

gcttgttacc cccttttcct cctctttgaa gacggagctg ccccagctgt ggctgggggt     1980

gtggaggcag tgggatgaac tgggggacag gtctgcgctg cagtgggatc tggctgctct     2040

gcctcctttc ccaccccagc tgaccatgag actttgctga gaagtggagg ccccaggaca     2100

ggctggctgg ctggctggct gcttgaccca gtgtgactct ccttcactga gtgataccct     2160

gctccgggcc catgccccaa ggagcccttc agagcccaca ctgccagtcg aggcctggct     2220

ggaggctggc cacagtggaa attctgccga gcctcttgtc ccttccctgc tctgctgcat     2280

ggggccccat ggctttggct ggccactgag ggtagggtgt ggaggtgtgg aggccccctg     2340

aggagctgcg gcggcccagg tacgaagctg caactctgcg cgcagtgggc gagatctcat     2400

cagccccagg ctgcaggtga ggcttcaggg gatgctgggg ccccactgcc cctccgctgc     2460

cttgccctcc atccttcctc tgttccttct ggccgggcac cacagcactg gggctcacct     2520

cttggttgat cctcttgtac tgggagaggt gccttttgta tccccaatta aaggtagaaa     2580

acc                                                                   2583


<210> 2156
<211> 6496
<212> DNA
<213> Homo sapiens

<400> 2156
ccgagccggg agccgagcgc gctgggcgcg gccgtcccgc tgccgccgcc aagcccggag       60

tgcgccagcg gccatggttc ccgcggcggc gccgggcgcc tgagccccgg gacgcaagcg      120

ctggaggcgg gctgccggct gtgcgggcgc tccggagaga ccgacagaag gtgagcactg      180

tgggctatgg gatggatgag gtggagcagg accagcatga ggcccgactc aaggagctgt      240

ttgacagttt tgacacgacg ggcacagggt ccctggggca ggaggaactc accgaccttt      300

gccacatgtt gagcttggag gaggtggccc cagtgctgca gcagacatta cttcaggaca      360

acctcttggg cagggtacat tttgaccaat ttaaagaagc attaatactc atcttgtcca      420

gaactctgtc aaatgaagaa cactttcaag aaccagactg ctcactagaa gctcagccca      480

aatatgttag aggtgggaag cgttacggac gaaggtcctt gcccgagttc caagagtccg      540

tggaggagtt tcctgaagtg acggtgattg agccactgga tgaagaagcg cggccttcac      600

acatcccagc cggtgactgc agtgagcact ggaagacgca acgcagtgag gagtatgaag      660

cggaaggcca gttaaggttt tggaacccag atgacttgaa tgcttcacag agtggatctt      720

cccctcccca agactggata gaagagaaac tgcaagaagt ttgtgaagat ttggggatca      780

cccgtgatgg tcacctgaac cggaagaagc tggtctccat ctgtgagcag tatggtttac      840

agaatgtgga tggagagatg ctcgaggaag tattccataa tcttgatcct gacggtacaa      900

tgagtgtaga agattttttc tatggtttgt ttaaaaatgg aaaatctctt acaccatcag      960

catctactcc atatagacaa ctaaaaaggc acctttccat gcagtctttc gatgagagtg     1020

gacgacgtac cacaacctca tcagcaatga caagtaccat tggctttcgg gtcttctcct     1080

gcctggatga tgggatgggc catgcatctg tggagagaat actggacacc tggcaggaag     1140

agggcattga gaacagccag gagatcctga aggccttgga tttcagcctc gatggaaaca     1200

tcaatttgac agaattaaca ctggcccttg aaaatgaact tttggttacc aagaacagca     1260

ttcaccaggc ggctctggcc agctttaagg ctgaaatccg gcatttgttg gaacgagttg     1320

atcaggtggt cagagaaaaa gagaagctac ggtcagatct ggacaaggcc gagaagctca     1380

agtctttaat ggcctcggag gtggatgatc accatgcggc catagagcgg cggaatgagt     1440

acaacctcag gaaactggat gaagagtaca aggagcgaat agcagcctta aaaaatgaac     1500

tccgaaaaga gagagagcag atcctgcagc aggcaggcaa gcagcgttta gaacttgaac     1560

aggaaattga aaaggcaaaa acagaagaga actatatccg ggaccgcctt gccctctctt     1620

taaaggaaaa cagtcgtctg gaaaatgagc ttctagaaaa tgcagagaag ttggcagaat     1680

atgagaatct gacaaacaaa cttcagagaa atttggaaaa tgtgttagca gaaaagtttg     1740

gtgacctcga tcctagcagt gctgagttct tcctgcaaga agagagactg acacagatga     1800

gaaatgaata tgagcggcag tgcagggtac tacaagacca agtagatgaa ctccagtctg     1860

agctggaaga atatcgtgca caaggcagag tgctcaggct tccgttgaag aactcaccgt     1920

cagaagaagt tgaggctaac agcggtggca ttgagcccga acacgggctc ggttctgaag     1980

aatgcaatcc attgaatatg agcattgagg cagagctggt cattgaacag atgaaagaac     2040

aacatcacag ggacatatgt tgcctcagac tggagctcga agataaagtg cgccattatg     2100

aaaagcagct ggacgaaacc gtggtcagct gcaagaaggc acaggagaac atgaagcaaa     2160

ggcatgagaa cgaaacgcac accttagaaa aacaaataag tgaccttaaa aatgaaattg     2220

ctgaacttca ggggcaagca gcagtgctca aggaggcaca tcatgaggcc acttgcaggc     2280

atgaggagga gaaaaaacaa ctgcaagtga agcttgagga ggaaaagact cacctgcagg     2340

agaagctgag gctgcaacat gagatggagc tcaaggctag actgacacag gctcaagcaa     2400

gctttgagcg ggagagggaa ggccttcaga gtagcgcctg gacagaagag aaggtgagag     2460

gcttgactca ggaactagag cagtttcacc aggagcagct gacaagcctg gtggagaaac     2520

acactcttga gaaagaggag ttaagaaaag agctcttgga aaagcaccaa agggagcttc     2580

aggagggaag ggaaaaaatg gaaacagagt gtaatagaag aacctctcaa atagaagccc     2640

agtttcagtc tgattgtcag aaagtcactg agaggtgtga aagcgctctg caaagcctgg     2700

aggggcgcta ccgccaagag ctgaaggacc tccaggaaca gcagcgtgag gagaaatccc     2760

agtgggaatt tgagaaggac gagctcaccc aggagtgtgc ggaagcccag gagctgctga     2820

aagagactct taagagagag aaaacaactt ctctggtcct gacccaggag agagagatgc     2880

tggagaaaac atacaaagaa catttgaaca gcatggtcgt cgagagacag cagctactcc     2940

aagacctgga agacctaaga aatgtatctg aaacccagca aagcctgctg tctgaccaga     3000

tacttgagct gaagagcagt cacaaaaggg aactgaggga gcgtgaggag gtcctgtgcc     3060

aggcaggggc ttcggagcag ctggccagcc agcggctgga aagactagaa atggaacatg     3120

accaggaaag gcaggaaatg atgtccaagc ttctagccat ggagaacatt cacaaagcga     3180

cctgtgagac agcagatcga gaaagagccg agatgagcac agaaatctcc agacttcaga     3240

gtaaaataaa ggaaatgcag caggcaacat ctcctctctc aatgcttcag agtggttgcc     3300

aggtgatagg agaggaggag gtggaaggag atggagccct gtccctgctt cagcaagggg     3360

agcagctgtt ggaagaaaat ggggacgtcc tcttaagcct gcagagagct catgaacagg     3420

cagtgaagga aaatgtgaaa atggctactg aaatttctag attgcaacag aggctacaaa     3480

agttagagcc agggttagta atgtcttctt gtttggatga gccagctact gagttttttg     3540

gaaatactgc ggaacaaaca gagcagtttt tacagcaaaa ccgaacgaag caagtagaag     3600

gtgtgaccag gcggcatgtc ctaagtgacc tggaagatga tgaggtccgg gacctgggaa     3660

gtacagggac gagctctgtt cagagacagg aagtcaaaat agaggagtct gaagcttcag     3720

tagagggttt ttctgagctt gaaaacagtg aagagaccag gactgaatcc tgggagctga     3780

agaatcagat tagtcagctt caggaacagc taatgatgtt atgtgcggac tgtgatcgag     3840

cttctgaaaa gaaacaggac ctactttttg atgtttctgt gctaaaaaag aaactgaaga     3900

tgcttgagag aatccctgag gcttctccca aatataagct gttgtatgaa gatgtgagcc     3960

gagaaaatga ctgccttcag gaagagctga gaatgatgga gacacgctac gatgaggcac     4020

tagaaaataa caaagaactc actgcagagg ttttcaggtt gcaggatgag ctgaagaaaa     4080

tggaggaagt cactgaaaca ttcctcagcc tggaaaagag ttacgatgag gtcaaaatag     4140

aaaatgaggg gctgaatgtt ctggttttga gacttcaagg caagattgag aagcttcagg     4200

aaagcgtggt ccagcggtgt gactgctgct tatgggaagc cagtttagag aacctggaaa     4260

tcgaacctga tggaaatata ctccagctca atcagacact ggaagagtgt gtgcccaggg     4320

ttaggagtgt acatcatgtc atagaggaat gtaagcaaga aaaccagtac cttgagggga     4380

acacacagct cttggaaaaa gtaaaagcac atgaaattgc ctggttacat ggaacaattc     4440

agacacatca agaaaggcca agagtacaga atcaagttat actggaggaa aacactactc     4500

tcctaggctt tcaagacaaa cattttcagc atcaggccac catagcagag ttagaactgg     4560

agaaaacaaa gttacaggag ctgactagga agttgaagga gagagtcact attttagtta     4620

agcaaaaaga tgtactttct cacggagaaa aggaggaaga gctgaaggca atgatgcatg     4680

acttgcagat cacgtgcagt gagatgcagc aaaaagttga acttctgaga tatgaatctg     4740

aaaagcttca acaggaaaat tctattttga gaaatgaaat tactacttta aatgaagaag     4800

atagcatttc taacctgaaa ttagggacat taaatggatc tcaggaagaa atgtggcaaa     4860

aaacggaaac tgtaaaacaa gaaaatgctg cagttcagaa gatggttgaa aatttaaaga     4920

aacagatttc agaattaaaa atcaaaaacc aacaattgga tttggaaaat acagaactta     4980

gccaaaagaa ctctcaaaac caggaaaaac tgcaagaact taatcaacgt ctaacagaaa     5040

tgctatgcca gaaggaaaaa gagccaggaa acagtgcatt ggaggaacgg gaacaagaga     5100

agtttaatct gaaagaagaa ctggaacgtt gtaaagtgca gtcctccact ttagtgtctt     5160

ctctggaggc ggagctctct gaagttaaaa tacagaccca tattgtgcaa caggaaaacc     5220

accttctcaa agatgaactg gagaaaatga aacagctgca cagatgtccc gatctctctg     5280

acttccagca aaaaatctct agtgttctaa gctacaacga aaaactgctg aaagaaaagg     5340

aagctctgag tgaggaatta aatagctgtg tcgataagtt ggcaaaatca agtcttttag     5400

agcatagaat tgcgacgatg aagcaggaac agaaatcctg ggaacatcag agtgcgagct     5460

taaagtcaca gctggtggct tctcaggaaa aggttcagaa tttagaagac accgtgcaga     5520

atgtaaacct gcaaatgtcc cggatgaaat ctgacctacg agtgactcag caggaaaagg     5580

aggctttaaa acaagaagtg atgtctttac ataagcaact tcagaatgct ggtggcaaga     5640

gctgggcccc agagatagct actcatccat cagggctcca taaccagcag aaaaggctgt     5700

cctgggacaa gttggatcat ctgatgaatg aggaacagca gctgctttgg caagagaatg     5760

agaggctcca gaccatggta cagaacacca aagccgaact cacgcactcc cgggagaagg     5820

tccgtcagtt ggaatccaat cttcttccca agcaccaaaa acatctaaac ccatcaggta     5880

ccatgaatcc cacagagcaa gaaaaattga gcttaaagag agagtgtgat cagtttcaga     5940

aagaacaatc tcctgctaac aggaaggtca gtcagatgaa ttcccttgaa caagaattag     6000

aaacaattca tttggaaaat gaaggcctga aaaagaaaca agtaaaactg gatgagcagc     6060

tcatggagat gcagcacctg aggtccactg cgacgcctag cccgtcccct catgcttggg     6120

atttgcagct gctccagcag caagcctgtc cgatggtgcc cagggagcag tttctgcagc     6180

ttcaacgcca gctgctgcag gcagaaagga taaaccagca cctgcaggag gaacttgaaa     6240

acaggacctc cgaaaccaac acaccacagg gaaaccagga acaactggta actgtcatgg     6300

aggaacgaat gatagaagtt gaacagaaac tgaaactagt gaaaaggctt cttcaagaga     6360

aagtgaatca gctcaaagaa caagtgagcc tacccggtca tctctgttca cccacctcac     6420

attccagctt taactccagt tttacatccc tttattgcca ttaactcgtt aacttatgtt     6480

gtctaataaa ggcaaa                                                     6496


<210> 2157
<211> 4216
<212> DNA
<213> Homo sapiens

<400> 2157
gagagaccga cagaaggtga gcactgtggg ctatgggatg gatgaggtgg agcaggacca       60

gcatgaggcc cgactcaagg agctgtttga cagttttgac acgacgggca cagggtccct      120

ggggcaggag gaactcaccg acctttgcca catgttgagc ttggaggagg tggccccagt      180

gctgcagcag acattacttc aggacaacct cttgggcagg gtacattttg accaatttaa      240

agaagcatta atactcatct tgtccagaac tctgtcaaat gaagaacact ttcaagaacc      300

agactgctca ctagaagctc agcccaaata tgttagaggt gggaagcgtt acggacgaag      360

gtccttgccc gagttccaag agtccgtgga ggagtttcct gaagtgacgg tgattgagcc      420

actggatgaa gaagcgcggc cttcacacat cccagccggt gactgcagtg agcactggaa      480

gacgcaacgc agtgaggagt atgaagcgga aggccagtta aggttttgga acccagatga      540

cttgaatgct tcacagagtg gatcttcccc tccccaagac tggatagaag agaaactgca      600

agaagtttgt gaagatttgg ggatcacccg tgatggtcac ctgaaccgga agaagctggt      660

ctccatctgt gagcagtatg gtttacagaa tgtggatgga gagatgctcg aggaagtatt      720

ccataatctt gatcctgacg gtacaatgag tgtagaagat tttttctatg gtttgtttaa      780

aaatggaaaa tctcttacac catcagcatc tactccatat agacaactaa aaaggcacct      840

ttccatgcag tctttcgatg agagtggacg acgtaccaca acctcatcag caatgacaag      900

taccattggc tttcgggtct tctcctgcct ggatgatggg atgggccatg catctgtgga      960

gagaatactg gacacctggc aggaagaggg cattgagaac agccaggaga tcctgaaggc     1020

cttggatttc agcctcgatg gaaacatcaa tttgacagaa ttaacactgg cccttgaaaa     1080

tgaacttttg gttaccaaga acagcattca ccaggcggct ctggccagct ttaaggctga     1140

aatccggcat ttgttggaac gagttgatca ggtggtcaga gaaaaagaga agctacggtc     1200

agatctggac aaggccgaga agctcaagtc tttaatggcc tcggaggtgg atgatcacca     1260

tgcggccata gagcggcgga atgagtacaa cctcaggaaa ctggatgaag agtacaagga     1320

gcgaatagca gccttaaaaa atgaactccg aaaagagaga gagcagatcc tgcagcaggc     1380

aggcaagcag cgtttagaac ttgaacagga aattgaaaag gcaaaaacag aagagaacta     1440

tatccgggac cgccttgccc tctctttaaa ggaaaacagt cgtctggaaa atgagcttct     1500

agaaaatgca gagaagttgg cagaatatga gaatctgaca aacaaacttc agagaaattt     1560

ggaaaatgtg ttagcagaaa agtttggtga cctcgatcct agcagtgctg agttcttcct     1620

gcaagaagag agactgacac agatgagaaa tgaatatgag cggcagtgca gggtactaca     1680

agaccaagta gatgaactcc agtctgagct ggaagaatat cgtgcacaag gcagagtgct     1740

caggcttccg ttgaagaact caccgtcaga agaagttgag gctaacagcg gtggcattga     1800

gcccgaacac gggctcggtt ctgaagaatg caatccattg aatatgagca ttgaggcaga     1860

gctggtcatt gaacagatga aagaacaaca tcacagggac atatgttgcc tcagactgga     1920

gctcgaagat aaagtgcgcc attatgaaaa gcagctggac gaaaccgtgg tcagctgcaa     1980

gaaggcacag gagaacatga agcaaaggca tgagaacgaa acgcacacct tagaaaaaca     2040

aataagtgac cttaaaaatg aaattgctga acttcagggg caagcagcag tgctcaagga     2100

ggcacatcat gaggccactt gcaggcatga ggaggagaaa aaacaactgc aagtgaagct     2160

tgaggaggaa aagactcacc tgcaggagaa gctgaggctg caacatgaga tggagctcaa     2220

ggctagactg acacaggctc aagcaagctt tgagcgggag agggaaggcc ttcagagtag     2280

cgcctggaca gaagagaagg tgagaggctt gactcaggaa ctagagcagt ttcaccagga     2340

gcagctgaca agcctggtgg agaaacacac tcttgagaaa gaggagttaa gaaaagagct     2400

cttggaaaag caccaaaggg agcttcagga gggaagatat gaatctgaaa agcttcaaca     2460

ggaaaattct attttgagaa atgaaattac tactttaaat gaagaagata gcatttctaa     2520

cctgaaatta gggacattaa atggatctca ggaagaaatg tggcaaaaaa cggaaactgt     2580

aaaacaagaa aatgctgcag ttcagaagat ggttgaaaat ttaaagaaac agatttcaga     2640

attaaaaatc aaaaaccaac aattggattt ggaaaataca gaacttagcc aaaagaactc     2700

tcaaaaccag gaaaaactgc aagaacttaa tcaacgtcta acagaaatgc tatgccagaa     2760

ggaaaaagag ccaggaaaca gtgcattgga ggaacgggaa caagagaagt ttaatctgaa     2820

agaagaactg gaacgttgta aagtgcagtc ctccacttta gtgtcttctc tggaggcgga     2880

gctctctgaa gttaaaatac agacccatat tgtgcaacag gaaaaccacc ttctcaaaga     2940

tgaactggag aaaatgaaac agctgcacag atgtcccgat ctctctgact tccagcaaaa     3000

aatctctagt gttctaagct acaacgaaaa actgctgaaa gaaaaggaag ctctgagtga     3060

ggaattaaat agctgtgtcg ataagttggc aaaatcaagt cttttagagc atagaattgc     3120

gacgatgaag caggaacaga aatcctggga acatcagagt gcgagcttaa agtcacagct     3180

ggtggcttct caggaaaagg ttcagaattt agaagacacc gtgcagaatg taaacctgca     3240

aatgtcccgg atgaaatctg acctacgagt gactcagcag gaaaaggagg ctttaaaaca     3300

agaagtgatg tctttacata agcaacttca gaatgctggt ggcaagagct gggccccaga     3360

gatagctact catccatcag ggctccataa ccagcagaaa aggctgtcct gggacaagtt     3420

ggatcatctg atgaatgagg aacagcagct gctttggcaa gagaatgaga ggctccagac     3480

catggtacag aacaccaaag ccgaactcac gcactcccgg gagaaggtcc gtcagttgga     3540

atccaatctt cttcccaagc accaaaaaca tctaaaccca tcaggtacca tgaatcccac     3600

agagcaagaa aaattgagct taaagagaga gtgtgatcag tttcagaaag aacaatctcc     3660

tgctaacagg aaggtcagtc agatgaattc ccttgaacaa gaattagaaa caattcattt     3720

ggaaaatgaa ggcctgaaaa agaaacaagt aaaactggat gagcagctca tggagatgca     3780

gcacctgagg tccactgcga cgcctagccc gtcccctcat gcttgggatt tgcagctgct     3840

ccagcagcaa gcctgtccga tggtgcccag ggagcagttt ctgcagcttc aacgccagct     3900

gctgcaggca gaaaggataa accagcacct gcaggaggaa cttgaaaaca ggacctccga     3960

aaccaacaca ccacagggaa accaggaaca actggtaact gtcatggagg aacgaatgat     4020

agaagttgaa cagaaactga aactagtgaa aaggcttctt caagagaaag tgaatcagct     4080

caaagaacaa gtgagcctac ccggtcatct ctgttcaccc acctcacatt ccagctttaa     4140

ctccagtttt acatcccttt attgccatta actcgttaac ttatgttgtc taataaaggc     4200

aaattctatt ataaat                                                     4216


<210> 2158
<211> 3317
<212> DNA
<213> Homo sapiens

<400> 2158
gttctccgct gaggaggagc ggggcagagg agggaggcag cgggtgagag ttcagagttc       60

agcagcagca gcccgagccc atgattccca tatgccctgt agtttctttc acctatgtgc      120

ccagccggct gggggaagat gccaaaatgg cgaccggcaa ctactttgga ttcacccaca      180

gcggggcggc ggcggcggcg gctgcggccc aatatagcca gcagccagct tcgggtgtag      240

cctattctca tccaactaca gttgctagct acactgtcca tcaggctcca gtagctgctc      300

acacagttac tgctgcctat gcaccagcag ccgccacagt tgcagttgcc aggcctgctc      360

cagtagctgt tgcagctgct gcaacagctg ctgcttatgg aggctacccc actgcacaca      420

cagcaactga ctatggttat actcagaggc aacaagaagc accaccacca ccacccccag      480

ctactacaca aaactaccag gattcatact catatgtaag gtccacagct cctgctgtag      540

cttatgatag taagcaatac taccaacaac caacagcaac tgctgctgct gtagctgccg      600

ctgcccaacc tcagccttct gttgctgaaa cttactatca gacagccccc aaagcaggtt      660

acagccaagg tgcaactcag tatactcaag cccagcaaac tcgacaagtg acagccataa      720

aaccagccac accaagtcca gctaccacta ctttctccat ctatcctgta tcctccaccg      780

tacagccagt agcagctgcg gctactgtgg tgccatccta tactcagagt gctacttaca      840

gtaccacagc agttacatat tctggtacgt cttattcagg ttatgaagca gcagtgtatt      900

cagctgcatc ttcctactat caacagcagc agcagcaaca gaagcaggca gcagcagcag      960

ctgctgctgc tgctgcaaca gctgcctgga cagggaccac ctttactaaa aaagcaccat     1020

tccaaaataa acaactgaaa ccaaaacagc ctcccaaacc accacagatt cactattgtg     1080

atgtttgtaa gatcagctgt gctggaccac agacttataa agaacattta gaaggacaga     1140

aacataaaaa aaaagaagct gcattgaaag cctcacaaaa taccagcagc agcaacagtt     1200

ctactcgtgg gactcaaaat cagctacgtt gtgagctctg cgatgtgtct tgtacaggag     1260

cagatgcgta tgctgcccac attcgtggtg ctaagcatca gaaagtggtt aagttacaca     1320

caaaacttgg taaacccatt ccatcaacag aaccaaatgt tgttagccaa gctacttctt     1380

caacagctgt atctgcttca aagccgactg cctctccttc aagcattgca gcaaacaatt     1440

gtactgtgaa tacgtcatca gttgcaacgt cttcaatgaa gggtcttacg actacaggaa     1500

actcgtctct taatagcaca tctaacacta aagtatcagc agtgcctaca aatatggctg     1560

ccaagaaaac atctaccccc aaaataaatt ttgttggtgg taataagctg cagtcaacag     1620

gaaataaagc agaagacata aaaggaaccg aatgtgttaa aagtactcct gtcacttctg     1680

ctgtgcagat tcctgaagta aagcaagaca cagtgtcaga accagtcaca cctgcatctc     1740

ttgctgcttt acagagtgat gtgcagccag tgggccatga ttatgtggaa gaggtacgaa     1800

atgatgaagg aaaagtaatt cggttccatt gtaaattatg cgagtgcagc tttaatgatc     1860

ccaatgctaa ggagatgcac ttaaaagggc gaagacacag acttcaatat aaaaaaaaag     1920

taaatccaga tttgcaagta gaagtaaagc ctagtattcg agcaagaaag attcaagaag     1980

agaaaatgag gaagcaaatg cagaaggagg agtactggcg aagacgagaa gaagaggagc     2040

gttggagaat ggaaatgaga cgttatgaag aggacatgta ctggaggaga atggaggaag     2100

aacaacatca ttgggatgat cgccgccgaa tgccagatgg aggttatcct catggtcctc     2160

caggcccatt aggccttctg ggagtccgac caggcatgcc tcctcagcct caggggcctg     2220

cacccttacg tcgtcctgac tcatctgatg accgttatgt aatgacaaaa catgccacca     2280

tttatccaac tgaagaggag ttacaggcag ttcagaaaat tgtttctatt actgaacgtg     2340

ctttaaaact cgtttcagac agtttgtctg aacatgagaa gaacaagaac aaagagggag     2400

atgataagaa agagggaggt aaagacagag ctttgaaagg agttttgcga gtgggagtat     2460

tggcaaaagg attacttctc cgaggagata gaaatgtcaa ccttgttttg ctgtgctcag     2520

agaaaccttc aaagacatta ttaagccgta ttgcagaaaa cctacccaaa cagcttgctg     2580

ttataagccc tgagaagtat gacataaaat gtgctgtatc tgaagcggca ataattttga     2640

attcatgtgt ggaacccaaa atgcaagtca ctatcacact gacatctcca attattcgag     2700

aagagaacat gagggaagga gatgtaacct cgggtatggt gaaagaccca ccggacgtct     2760

tggacaggca aaaatgcctt gacgctctgg ctgctctacg ccacgctaag tggttccagc     2820

aagctagagc taatggtctg cagtcctgtg tgattatcat acgcattctt cgagacctct     2880

gtcagcgagt tccaacttgg tctgattttc caagctgggc tatggagtta ctagtagaga     2940

aagcaatcag cagtgcttct agccctcaga gccctgggga tgcactgaga agagtttttg     3000

aatgcatttc ttcagggatt attcttaaag gtagtcctgg acttctggat ccttgtgaaa     3060

aggatccctt tgataccttg gcaacaatga ctgaccagca gcgtgaagac atcacatcca     3120

gtgcacagtt tgcattgaga ctccttgcat tccgccagat acacaaagtt ctaggcatgg     3180

atccattacc gcaaatgagc caacgtttta acatccacaa caacaggaaa cgaagaagag     3240

atagtgatgg aatggatttg aagctgaggg gaaaaaagac aaaaaagatt atgataactt     3300

ttaaaaagtg tctgtaa                                                    3317


<210> 2159
<211> 561
<212> DNA
<213> Homo sapiens

<400> 2159
cctccctctc acctgctcct ctacctgctc caccctcaat ccaccagaac catgggctgc       60

tgtggctgct ctggaggctg tggctccggc tgtgggggct gtggctctgg ctgtgggggc      120

tgtgggtcca gctgctgtgt gcccatctgc tgctgcaagc ccgtgtgctg ctgtgtgcca      180

gcctgttcct gcaccagctg tggctcttgt gggggctcca aggggtgctg tggctcttgt      240

gggggctcca aagggggctg tggctcttgt gggggctcca agggaggctg tggctcttgt      300

ggctgctccc agtgcagttg ctgcaagccc tgctactgtt cctcaggctg tgggtcatcc      360

tgctgccagt ccagctgctg caagccctgc tgttcccagg ccagctgctg tgtccccatt      420

tgctgccagt gcaaaatctg aggctctgac tttggacctc aggtgagtcc agcatatcca      480

caccacccaa gaagtgacca gtgctgcatt tcagttctgg ctgtcccaca gctccaggag      540

ttgtgtcccc tgaattttgc a                                                561


<210> 2160
<211> 1958
<212> DNA
<213> Homo sapiens

<400> 2160
gttttggcac gacagttatg aaaaagaaag acacttgagg gattccgggt tttcactttg       60

gaattggaga taagggatcg tgggcccgtg tagtctcgga agaggttgtg tagtttagga      120

tcaaagagct ggccgtgatg agggcaggga tgcaggcgca gcccgtctga ctccaaactg      180

ccttgctctt aacccgactg caagaccctc aagaacacgg gccccatggt tttcctctta      240

tgtttctatc atctctaaaa tacaacagcc tggtgggcag ggcctcctgc actggccatg      300

cccatgccca cggagggcac cccgccacct ctgagtggca cccccatccc agtcccagcc      360

tacttccgcc acgcagaacc tggattctcc ctcaagaggc ccagggggct cagccggagc      420

ctcccacctc cgccccctgc caagggcagc attcccatca gccgcctctt ccctcctcgg      480

accccaggct ggcaccagct gcagccccgg cgggtgtcat tccggggcga ggcctcagag      540

actctgcaga gccctgggta tgacccaagc cggccagagt ccttcttcca gcagagcttc      600

cagaggctca gccgcctggg ccatggctcc tacggagagg tcttcaaggt gcgctccaag      660

gaggacggcc ggctctatgc ggtaaagcgt tccatgtcac cattccgggg ccccaaggac      720

cgggcccgca agttggccga ggtgggcagc cacgagaagg tggggcagca cccatgctgc      780

gtgcggctgg agcaggcctg ggaggagggc ggcatcctgt acctgcagac ggagctgtgc      840

gggcccagcc tgcagcaaca ctgtgaggcc tggggtgcca gcctgcctga ggcccaggtc      900

tggggctacc tgcgggacac gctgcttgcc ctggcccatc tgcacagcca gggcctggtg      960

caccttgatg tcaagcctgc caacatcttc ctggggcccc ggggccgctg caagctgggt     1020

gacttcggac tgctggtgga gctgggtaca gcaggagctg gtgaggtcca ggagggagac     1080

ccccgctaca tggcccccga gctgctgcag ggctcctatg ggacagcagc ggatgtgttc     1140

agtctgggcc tcaccatcct ggaagtggca tgcaacatgg agctgcccca cggtggggag     1200

ggctggcagc agctgcgcca gggctacctg ccccctgagt tcactgccgg tctgtcttcc     1260

gagctgcgtt ctgtccttgt catgatgctg gagccagacc ccaagctgcg ggccacggcc     1320

gaggccctgc tggcactgcc tgtgttgagg cagccgcggg cctggggtgt gctgtggtgc     1380

atggcagcgg aggccctgag ccgagggtgg gccctgtggc aggccctgct tgccctgctc     1440

tgctggctct ggcatgggct ggctcaccct gccagctggc tacagcccct gggcccgcca     1500

gccaccccgc ctggctcacc accctgcagt ttgctcctgg acagcagcct ctccagcaac     1560

tgggatgacg acagcctagg tccatgtgtt ctgaaaagga cagagggggc cttggagtgc     1620

agccagatgg aaggactttg aaggctgtcc aagtgctgct ttcagagtgc accaagtttt     1680

tattgtccct gactgtggct ccctgcctgt ttgtcaggcg ggagcctgga gcctgcacag     1740

ggacagagct ggtttcatcc ggcactccct agccctggac accctccttg tctcgcctgc     1800

cctcctgcag gccttcactc tcccctgagg ctgtcctggc ccggactgtg gggagcacct     1860

ccaccccccg gagcaggtgc acacccaggg atgccctgga cctaagtgac atcaactcag     1920

agcctcctcg gggctccttc ccctcctttg agcctcgg                             1958


<210> 2161
<211> 3759
<212> DNA
<213> Homo sapiens

<400> 2161
cacgcgcccc gatacccggc acaggagcca cctcccagag ccccgcagtc catgcctcag       60

tcggcctgcg ctcctcagcc tggcggttct acctccgagg gttcgcccgc ccttggtttt      120

ccttacacct tagcctttgg ctcctttgac cactcgaagc cccacagcgt gttccagcgg      180

acttcaccag cagacccaga agtggtgggt gaaacactgc ctctgttcct ccttgagcct      240

gtcgggagct gctgcctgcc accaccatgt ctgctgcaaa tcctgagact ccaaactcaa      300

ccatctccag agaggccagc acccagtctt catcagctgc agctagccaa ggctgggtgt      360

taccagaagg caaaatcgtg ccaaacactg tttttgttgg tggaattgat gctaggatgg      420

atgaaactga gattggaagc tgctttggta gatacggttc agtgaaagaa gtgaagataa      480

tcacgaatcg aactggtgtg tccaaaggct atggatttgt ttcgtttgtt aatgacgtgg      540

atgtccagaa gatagtagga tcacagatac atttccatgg taaaaagctg aagctgggcc      600

ctgcaatcag gaaacaaaag ttatgtgctc gtcatgtgca gccacgtcct ttggtagtta      660

atcctcctcc tccaccacag tttcagaacg tctggcggaa tccaaacact gaaacctacc      720

tgcagcccca aatcacgccg aatcctgtaa ctcagcacgt tcaggcttac tctgcttatc      780

cacattcacc aggtcaggtc atcactggat gtcagttgct tgtatataat tatcaggaat      840

atcctactta tcccgattca gcatttcagg tcaccactgg atatcagttg cctgtatata      900

attatcagcc atttcctgct tatccaagat caccatttca ggtcactgct ggatatcagt      960

tgcctgtata taattatcag gcatttcctg cttatccaaa ttcaccattt caagtcgcca     1020

ctggatatca gttccctgta tacaattatc agccatttcc tgcttatcca agttcaccat     1080

ttcaggtcac tgctggatat cagttgcctg tatataatta tcaggcattt cctgcttatc     1140

caaattcacc atttcaagtc gccactggat atcagttccc tgtatacaat tatcaggcat     1200

ttcctgctta tccaaattca ccagttcagg tcaccactgg atatcagttg cctgtataca     1260

attatcaggc atttcctgct tatccaaatt caccagttca ggtcaccact ggatatcagt     1320

tgcctgtata caattatcag gcatttcctg cttatccaag ttcaccattt caggtcacca     1380

ctggatatca gttgcctgta tataattatc aggcatttcc tgcttatcca agttcaccat     1440

ttcaggtcac cactggatat cagttgcctg tatataatta tcaggcattt cctgcttatc     1500

caagttcacc atttcaggtc accactggat atcagttgcc tgtatataat tatcaggcat     1560

ttcctgctta tccaagttca ccatttcagg tcaccactgg atatcagttg cctgtatata     1620

attatcaggc atttcctgct tatccaagtt caccatttca ggtcaccact ggatatcagt     1680

tgcctgtata taattatcag gcatttcctg cttatccaaa ttcagcagtt caggtcacca     1740

ctggatatca gttccatgta tacaattacc agatgccacc gcagtgccct gttggggagc     1800

aaaggagaaa tctgtggacc gaagcataca aatggtggta tcttgtctgt ttaatccaga     1860

gaagagactg ataaattccg ttgttactca agatgactgc ttcaagggta aaagagtgca     1920

tcgctttaga agaagtttgg cagtatttaa atctgttgga tcctctcagc tatctagttt     1980

catgggaagt tgctggtttt gaatattaag ctaaaagttt tccactatta cagaaattct     2040

gaattttggt aaatcacact gaaactttct gtataacttg tattattaga ctctctagtt     2100

ttatcttaac actgaaactg ttcttcatta gatgtttatt tagaacctgg ttctgtgttt     2160

aatatatagt ttaaagtaac aaataatcga gactgaaaga atgttaagat ttatctgcaa     2220

ggatttttaa aaaattgaaa cttgcatttt aagtgtttaa aagcaaatac tgactttcaa     2280

aaaagttttt aaaacctgat ttgaaagcta acaattttga tagtctgaac acaagcattt     2340

cacttctcca agaagtacct gtgaacagta caatatttca gtattgagct ttgcatttat     2400

gatttatcta gaaatttacc tcaaaagcag aatttttaaa actgcatttt taatcagtgg     2460

aactcaatgt atagttagct ttattgaagt cttatccaaa cccagtaaaa cagattctaa     2520

gcaaacagtc caatcagtga gtcataatgt ttattcaaag tattttatct tttatctaga     2580

atccacatat gtatgtccaa tttgattggg atagtagtta ggataactaa aattctgggc     2640

ctaatttttt aaagaatcca agacaaacta aactttactg ggtatataac cttctcaatg     2700

agttaccatt cttttttata aaaaaaattg ttccttgaaa tgctaaactt aatggctgta     2760

tgtgaaattt gcaaaatact ggtattaaag aacgctgcag cttttttatg tcactcaaag     2820

gttaatcgga gtatctgaaa ggaattgttt ttataaaaac attgaagtat tagttacttg     2880

ctataaatag atttttattt ttgtttttta gcctgttata tttccttctg taaaataaaa     2940

tatgtccaga agaggcatgt tgtttctaga ttaggtagtg tcctcatttt atattgtgac     3000

cacacagcta gagcaccaga gcccttttgc tatactcaca gtcttgtttt cccagcctct     3060

tttactagtc tttcaggagg tttgctctta gaactggtga tgtaaagaat ggaagtagct     3120

gtatgagcag ttcaaaggcc aagccgtgga atggtagcaa tgggatataa tacctttcta     3180

agggaaacat ttgtatcagt atcatttgat ctgccatgga catgtgttta aagtggcttt     3240

ctggcccttc tttcaatggc ttcttcccta aaacgtggag actctaagtt aatgtcgtta     3300

ctatgggcca tattactaat gcccactggg gtctatgatt tctcaaaatt ttcattcgga     3360

atccgaagga tacagtcttt aaactttaga attcccaaga aggctttatt acacctcaga     3420

aattgaaagc accatgactt tgtccattaa aaaattatcc atagtttttt tagtgctttt     3480

aacattccga catacatcat tctgtgatta aatctccaga tttctgtaaa tgatacctac     3540

attctaaaga gttaattcta attattccga tatgacctta aggaaaagta aaggaataaa     3600

tttttgtctt tgttgaagta tttaatagag taaggtaaag aagatattaa gtccctttca     3660

aaatggaaaa ttaattctaa actgagaaaa atgttcctac tacctattgc tgatactgtc     3720

tttgcataaa tgaataaaaa taaacttttt ttcttcaaa                            3759


<210> 2162
<211> 1392
<212> DNA
<213> Homo sapiens

<400> 2162
tcagtcggcc tgcgctcctc agcctggcgg ttctacctcc gagggttcgc ccgcccttgg       60

ttttccttac accttagcct ttggctcctt tgaccactcg aagccccaca gcgtgttcca      120

gcggacttca ccagcagacc cagaagtggt gggtgaaaca ctgcctctgt tcctccttga      180

gcctgtcggg agctgctgcc tgccaccacc atgtctgctg caaatcctga gactccaaac      240

tcaaccatct ccagagaggc cagcacccag tcttcatcag ctgcagctag ccaaggctgg      300

gtgttaccag aaggcaaaat cgtgccaaac actgtttttg ttggtggaat tgatgctagg      360

atggatgaaa ctgagattgg aagctgcttt ggtagatacg gttcagtgaa agaagtgaag      420

ataatcacga atcgaactgg tgtgtccaaa ggctatggat ttgtttcgtt tgttaatgac      480

gtggatgtcc agaagatagt aggatcacag atacatttcc atggtaaaaa gctgaagctg      540

ggccctgcaa tcaggaaaca aaagttatgt gctcgtcatg tgcagccacg tcctttggta      600

gttaatcctc ctcctccacc acagtttcag aacgtctggc ggaatccaaa cactgaaacc      660

tacctgcagc cccaaatcac gccgaatcct gtaactcagc acgttcaggc ttactctgct      720

tatccacatt caccaggtca ggtcatcact ggatgtcagt tgcttgtata taattatcag      780

gaatatccta cttatcccga ttcagcattt caggtcacca ctggatatca gttgcctgta      840

tataattatc agccatttcc tgcttatcca agatcaccat ttcaggtcac tgctggatat      900

cagttgcctg tatataatta tcaggcattt cctgcttatc caaattcacc atttcaagtc      960

gccactggat atcagttccc tgtatacaat tatcagccat ttcctgctta tccaagttca     1020

ccatttcagg tcactgctgg atatcagttg cctgtatata attatcaggc atttcctgct     1080

tatccaaatt caccagttca ggtcaccact ggatatcagt tgcctgtata caattatcag     1140

gcatttcctg cttatccaag ttcaccattt caggtcacca ctggatatca gttgcctgta     1200

tataattatc aggcatttcc tgcttatcca aattcagcag ttcaggtcac cactggatat     1260

cagttccatg tatacaatta ccagatgcca ccgcagtgcc ctgttgggga gcaaaggaga     1320

aatctgtgga ccgaagcata caaatggtgg tatcttgtct gtttaatcca gagaagagac     1380

tgataaattc cg                                                         1392


<210> 2163
<211> 3273
<212> DNA
<213> Homo sapiens

<400> 2163
tcagtcggcc tgcgctcctc agcctggcgg ttctacctcc gagggttcgc ccgcccttgg       60

ttttccttac accttagcct ttggctcctt tgaccactcg aagccccaca gcgtgttcca      120

gcggacttca ccagcagacc cagaagtggt gggtgaaaca ctgcctctgt tcctccttga      180

gcctgtcggg agctgctgcc tgccaccacc atgtctgctg caaatcctga gactccaaac      240

tcaaccatct ccagagaggc cagcacccag tcttcatcag ctgcagctag ccaaggctgg      300

gtgttaccag aaggcaaaat cgtgccaaac actgtttttg ttggtggaat tgatgctagg      360

atggatgaaa ctgagattgg aagctgcttt ggtagatacg gttcagtgaa agaagtgaag      420

ataatcacga atcgaactgg tgtgtccaaa ggctatggat ttgtttcgtt tgttaatgac      480

gtggatgtcc agaagatagt aggatcacag atacatttcc atggtaaaaa gctgaagctg      540

ggccctgcaa tcaggaaaca aaagttatgt gctcgtcatg tgcagccacg tcctttggta      600

gttaatcctc ctcctccacc acagtttcag aacgtctggc ggaatccaaa cactgaaacc      660

tacctgcagc cccaaatcac gccgaatcct gtaactcagc acgttcaggc ttactctgct      720

tatccacatt caccaggtca ggtcatcact ggatgtcagt tgcttgtata taattatcag      780

gaatatccta cttatcccga ttcagcattt caggtcacca ctggatatca gttgcctgta      840

tataattatc agccatttcc tgcttatcca agatcaccat ttcaggtcac tgctggatat      900

cagttgcctg tatataatta tcaggcattt cctgcttatc caaattcacc atttcaagtc      960

gccactggat atcagttccc tgtatacaat tatcagccat ttcctgctta tccaagttca     1020

ccatttcagg tcactgctgg atatcagttg cctgtatata attatcaggc atttcctgct     1080

tatccaaatt caccagttca ggtcaccact ggatatcagt tgcctgtata caattatcag     1140

gcatttcctg cttatccaag ttcaccattt caggtcacca ctggatatca gttgcctgta     1200

tataattatc aggcatttcc tgcttatcca aattcagcag ttcaggtcac cactggatat     1260

cagttccatg tatacaatta ccagatgcca ccgcagtgcc ctgttgggga gcaaaggaga     1320

aatctgtgga ccgaagcata caaatggtgg tatcttgtct gtttaatcca gagaagagac     1380

tgataaattc cgttgttact caagatgact gcttcaaggg taaaagagtg catcgcttta     1440

gaagaagttt ggcagtattt aaatctgttg gatcctctca gctatctagt ttcatgggaa     1500

gttgctggtt ttgaatatta agctaaaagt tttccactat tacagaaatt ctgaattttg     1560

gtaaatcaca ctgaaacttt ctgtataact tgtattatta gactctctag ttttatctta     1620

acactgaaac tgttcttcat tagatgttta tttagaacct ggttctgtgt ttaatatata     1680

gtttaaagta acaaataatc gagactgaaa gaatgttaag atttatctgc aaggattttt     1740

aaaaaattga aacttgcatt ttaagtgttt aaaagcaaat actgactttc aaaaaagttt     1800

ttaaaacctg atttgaaagc taacaatttt gatagtctga acacaagcat ttcacttctc     1860

caagaagtac ctgtgaacag tacaatattt cagtattgag ctttgcattt atgatttatc     1920

tagaaattta cctcaaaagc agaattttta aaactgcatt tttaatcagt ggaactcaat     1980

gtatagttag ctttattgaa gtcttatcca aacccagtaa aacagattct aagcaaacag     2040

tccaatcagt gagtcataat gtttattcaa agtattttat cttttatcta gaatccacat     2100

atgtatgtcc aatttgattg ggatagtagt taggataact aaaattctgg gcctaatttt     2160

ttaaagaatc caagacaaac taaactttac tgggtatata accttctcaa tgagttacca     2220

ttctttttta taaaaaaaat tgttccttga aatgctaaac ttaatggctg tatgtgaaat     2280

ttgcaaaata ctggtattaa agaacgctgc agctttttta tgtcactcaa aggttaatcg     2340

gagtatctga aaggaattgt ttttataaaa acattgaagt attagttact tgctataaat     2400

agatttttat ttttgttttt tagcctgtta tatttccttc tgtaaaataa aatatgtcca     2460

gaagaggcat gttgtttcta gattaggtag tgtcctcatt ttatattgtg accacacagc     2520

tagagcacca gagccctttt gctatactca cagtcttgtt ttcccagcct cttttactag     2580

tctttcagga ggtttgctct tagaactggt gatgtaaaga atggaagtag ctgtatgagc     2640

agttcaaagg ccaagccgtg gaatggtagc aatgggatat aatacctttc taagggaaac     2700

atttgtatca gtatcatttg atctgccatg gacatgtgtt taaagtggct ttctggccct     2760

tctttcaatg gcttcttccc taaaacgtgg agactctaag ttaatgtcgt tactatgggc     2820

catattacta atgcccactg gggtctatga tttctcaaaa ttttcattcg gaatccgaag     2880

gatacagtct ttaaacttta gaattcccaa gaaggcttta ttacacctca gaaattgaaa     2940

gcaccatgac tttgtccatt aaaaaattat ccatagtttt tttagtgctt ttaacattcc     3000

gacatacatc attctgtgat taaatctcca gatttctgta aatgatacct acattctaaa     3060

gagttaattc taattattcc gatatgacct taaggaaaag taaaggaata aatttttgtc     3120

tttgttgaag tatttaatag agtaaggtaa agaagatatt aagtcccttt caaaatggaa     3180

aattaattct aaactgagaa aaatgttcct actacctatt gctgatactg tctttgcata     3240

aatgaataaa aataaacttt ttttcttcaa atg                                  3273


<210> 2164
<211> 3287
<212> DNA
<213> Homo sapiens

<400> 2164
gctgccaccc attggctcag gccgatacca cgcgccccga tacccggcac aggagccacc       60

tcccagagcc ccgcagtcca tgcctcagtc ggcctgcgct cctcagcctg gcggttctac      120

ctccgagggt tcgcccgccc ttggttttcc ttacacctta gcctttggct cctttgacca      180

ctcgaagccc cacagcgtgt tccagcggac ttcaccagca gacccagaag tggtgggtga      240

aacactgcct ctgttcctcc ttgagcctgt cgggagctgc tgcctgccac caccatgtct      300

gctgcaaatc ctgagactcc aaactcaacc atctccagag aggccagcac ccagtcttca      360

tcagctgcag ctagccaagg ctgggtgtta ccagaaggca aaatcgtgcc aaacactgtt      420

tttgttggtg gaattgatgc taggatggat gaaactgaga ttggaagctg ctttggtaga      480

tacggttcag tgaaagaagt gaagataatc acgaatcgaa ctggtgtgtc caaaggctat      540

ggatttgttt cgtttgttaa tgacgtggat gtccagaaga tagtaggatc acagatacat      600

ttccatggta aaaagctgaa gctgggccct gcaatcagga aacaaaagtt atgtgctcgt      660

catgtgcagc cacgtccttt ggtagttaat cctcctcctc caccacagtt tcagaacgtc      720

tggcggaatc caaacactga aacctacctg cagccccaaa tcacgccgaa tcctgtaact      780

cagcacgttc aggcttactc tgcttatcca cattcaccag gtcaggtcat cactggatgt      840

cagttgcttg tatataatta tcaggaatat cctacttatc ccgattcagc atttcaggtc      900

accactggat atcagttgcc tgtatataat tatcagccat ttcctgctta tccaagatca      960

ccatttcagg tcactgctgg atatcagttg cctgtatata attatcaggc atttcctgct     1020

tatccaaatt caccatttca agtcgccact ggatatcagt tccctgtata caattatcag     1080

ccatttcctg cttatccaag ttcaccattt caggtcactg ctggatatca gttgcctgta     1140

tataattatc aggcatttcc tgcttatcca aattcaccag ttcaggtcac cactggatat     1200

cagttgcctg tatacaatta tcaggcattt cctgcttatc caaattcagc agttcaggtc     1260

accactggat atcagttcca tgtatacaat taccagatgc caccgcagtg ccctgttggg     1320

gagcaaagga gaaatctgtg gaccgaagca tacaaatggt ggtatcttgt ctgtttaatc     1380

cagagaagag actgataaat tccgttgtta ctcaagatga ctgcttcaag ggtaaaagag     1440

tgcatcgctt tagaagaagt ttggcagtat ttaaatctgt tggatcctct cagctatcta     1500

gtttcatggg aagttgctgg ttttgaatat taagctaaaa gttttccact attacagaaa     1560

ttctgaattt tggtaaatca cactgaaact ttctgtataa cttgtattat tagactctct     1620

agttttatct taacactgaa actgttcttc attagatgtt tatttagaac ctggttctgt     1680

gtttaatata tagtttaaag taacaaataa tcgagactga aagaatgtta agatttatct     1740

gcaaggattt ttaaaaaatt gaaacttgca ttttaagtgt ttaaaagcaa atactgactt     1800

tcaaaaaagt ttttaaaacc tgatttgaaa gctaacaatt ttgatagtct gaacacaagc     1860

atttcacttc tccaagaagt acctgtgaac agtacaatat ttcagtattg agctttgcat     1920

ttatgattta tctagaaatt tacctcaaaa gcagaatttt taaaactgca tttttaatca     1980

gtggaactca atgtatagtt agctttattg aagtcttatc caaacccagt aaaacagatt     2040

ctaagcaaac agtccaatca gtgagtcata atgtttattc aaagtatttt atcttttatc     2100

tagaatccac atatgtatgt ccaatttgat tgggatagta gttaggataa ctaaaattct     2160

gggcctaatt ttttaaagaa tccaagacaa actaaacttt actgggtata taaccttctc     2220

aatgagttac cattcttttt tataaaaaaa attgttcctt gaaatgctaa acttaatggc     2280

tgtatgtgaa atttgcaaaa tactggtatt aaagaacgct gcagcttttt tatgtcactc     2340

aaaggttaat cggagtatct gaaaggaatt gtttttataa aaacattgaa gtattagtta     2400

cttgctataa atagattttt atttttgttt tttagcctgt tatatttcct tctgtaaaat     2460

aaaatatgtc cagaagaggc atgttgtttc tagattaggt agtgtcctca ttttatattg     2520

tgaccacaca gctagagcac cagagccctt ttgctatact cacagtcttg ttttcccagc     2580

ctcttttact agtctttcag gaggtttgct cttagaactg gtgatgtaaa gaatggaagt     2640

agctgtatga gcagttcaaa ggccaagccg tggaatggta gcaatgggat ataatacctt     2700

tctaagggaa acatttgtat cagtatcatt tgatctgcca tggacatgtg tttaaagtgg     2760

ctttctggcc cttctttcaa tggcttcttc cctaaaacgt ggagactcta agttaatgtc     2820

gttactatgg gccatattac taatgcccac tggggtctat gatttctcaa aattttcatt     2880

cggaatccga aggatacagt ctttaaactt tagaattccc aagaaggctt tattacacct     2940

cagaaattga aagcaccatg actttgtcca ttaaaaaatt atccatagtt tttttagtgc     3000

ttttaacatt ccgacataca tcattctgtg attaaatctc cagatttctg taaatgatac     3060

ctacattcta aagagttaat tctaattatt ccgatatgac cttaaggaaa agtaaaggaa     3120

taaatttttg tctttgttga agtatttaat agagtaaggt aaagaagata ttaagtccct     3180

ttcaaaatgg aaaattaatt ctaaactgag aaaaatgttc ctactaccta ttgctgatac     3240

tgtctttgca taaatgaata aaaataaact ttttttcttc aaatgtg                   3287


<210> 2165
<211> 3831
<212> DNA
<213> Homo sapiens

<400> 2165
cacgcgcccc gatacccggc acaggagcca cctcccagag ccccgcagtc catgcctcag       60

tcggcctgcg ctcctcagcc tggcggttct acctccgagg gttcgcccgc ccttggtttt      120

ccttacacct tagcctttgg ctcctttgac cactcgaagc cccacagcgt gttccagcgg      180

acttcaccag cagacccaga agtggtgggt gaaacactgc ctctgttcct ccttgagcct      240

gtcgggagct gctgcctgcc accaccatgt ctgctgcaaa tcctgagact ccaaactcaa      300

ccatctccag agaggccagc acccagtctt catcagctgc agctagccaa ggctgggtgt      360

taccagaagg caaaatcgtg ccaaacactg tttttgttgg tggaattgat gctaggatgg      420

atgaaactga gattggaagc tgctttggta gatacggttc agtgaaagaa gtgaagataa      480

tcacgaatcg aactggtgtg tccaaaggct atggatttgt ttcgtttgtt aatgacgtgg      540

atgtccagaa gatagtagga tcacagatac atttccatgg taaaaagctg aagctgggcc      600

ctgcaatcag gaaacaaaag ttatgtgctc gtcatgtgca gccacgtcct ttggtagtta      660

atcctcctcc tccaccacag tttcagaacg tctggcggaa tccaaacact gaaacctacc      720

tgcagcccca aatcacgccg aatcctgtaa ctcagcacgt tcaggcttac tctgcttatc      780

cacattcacc aggtcaggtc atcactggat gtcagttgct tgtatataat tatcaggaat      840

atcctactta tcccgattca gcatttcagg tcaccactgg atatcagttg cctgtatata      900

attatcagcc atttcctgct tatccaagat caccatttca ggtcactgct ggatatcagt      960

tgcctgtata taattatcag gcatttcctg cttatccaaa ttcaccattt caagtcgcca     1020

ctggatatca gttccctgta tacaattatc agccatttcc tgcttatcca agttcaccat     1080

ttcaggtcac tgctggatat cagttgcctg tatataatta tcaggcattt cctgcttatc     1140

caaattcacc atttcaagtc gccactggat atcagttccc tgtatacaat tatcaggcat     1200

ttcctgctta tccaaattca ccagttcagg tcaccactgg atatcagttg cctgtataca     1260

attatcaggc atttcctgct tatccaaatt caccatttca agtcgccact ggatatcagt     1320

tccctgtata caattatcag gcatttcctg cttatccaaa ttcaccagtt caggtcacca     1380

ctggatatca gttgcctgta tacaattatc aggcatttcc tgcttatcca agttcaccat     1440

ttcaggtcac cactggatat cagttgcctg tatataatta tcaggcattt cctgcttatc     1500

caagttcacc atttcaggtc accactggat atcagttgcc tgtatataat tatcaggcat     1560

ttcctgctta tccaagttca ccatttcagg tcaccactgg atatcagttg cctgtatata     1620

attatcaggc atttcctgct tatccaagtt caccatttca ggtcaccact ggatatcagt     1680

tgcctgtata taattatcag gcatttcctg cttatccaag ttcaccattt caggtcacca     1740

ctggatatca gttgcctgta tataattatc aggcatttcc tgcttatcca aattcagcag     1800

ttcaggtcac cactggatat cagttccatg tatacaatta ccagatgcca ccgcagtgcc     1860

ctgttgggga gcaaaggaga aatctgtgga ccgaagcata caaatggtgg tatcttgtct     1920

gtttaatcca gagaagagac tgataaattc cgttgttact caagatgact gcttcaaggg     1980

taaaagagtg catcgcttta gaagaagttt ggcagtattt aaatctgttg gatcctctca     2040

gctatctagt ttcatgggaa gttgctggtt ttgaatatta agctaaaagt tttccactat     2100

tacagaaatt ctgaattttg gtaaatcaca ctgaaacttt ctgtataact tgtattatta     2160

gactctctag ttttatctta acactgaaac tgttcttcat tagatgttta tttagaacct     2220

ggttctgtgt ttaatatata gtttaaagta acaaataatc gagactgaaa gaatgttaag     2280

atttatctgc aaggattttt aaaaaattga aacttgcatt ttaagtgttt aaaagcaaat     2340

actgactttc aaaaaagttt ttaaaacctg atttgaaagc taacaatttt gatagtctga     2400

acacaagcat ttcacttctc caagaagtac ctgtgaacag tacaatattt cagtattgag     2460

ctttgcattt atgatttatc tagaaattta cctcaaaagc agaattttta aaactgcatt     2520

tttaatcagt ggaactcaat gtatagttag ctttattgaa gtcttatcca aacccagtaa     2580

aacagattct aagcaaacag tccaatcagt gagtcataat gtttattcaa agtattttat     2640

cttttatcta gaatccacat atgtatgtcc aatttgattg ggatagtagt taggataact     2700

aaaattctgg gcctaatttt ttaaagaatc caagacaaac taaactttac tgggtatata     2760

accttctcaa tgagttacca ttctttttta taaaaaaaat tgttccttga aatgctaaac     2820

ttaatggctg tatgtgaaat ttgcaaaata ctggtattaa agaacgctgc agctttttta     2880

tgtcactcaa aggttaatcg gagtatctga aaggaattgt ttttataaaa acattgaagt     2940

attagttact tgctataaat agatttttat ttttgttttt tagcctgtta tatttccttc     3000

tgtaaaataa aatatgtcca gaagaggcat gttgtttcta gattaggtag tgtcctcatt     3060

ttatattgtg accacacagc tagagcacca gagccctttt gctatactca cagtcttgtt     3120

ttcccagcct cttttactag tctttcagga ggtttgctct tagaactggt gatgtaaaga     3180

atggaagtag ctgtatgagc agttcaaagg ccaagccgtg gaatggtagc aatgggatat     3240

aatacctttc taagggaaac atttgtatca gtatcatttg atctgccatg gacatgtgtt     3300

taaagtggct ttctggccct tctttcaatg gcttcttccc taaaacgtgg agactctaag     3360

ttaatgtcgt tactatgggc catattacta atgcccactg gggtctatga tttctcaaaa     3420

ttttcattcg gaatccgaag gatacagtct ttaaacttta gaattcccaa gaaggcttta     3480

ttacacctca gaaattgaaa gcaccatgac tttgtccatt aaaaaattat ccatagtttt     3540

tttagtgctt ttaacattcc gacatacatc attctgtgat taaatctcca gatttctgta     3600

aatgatacct acattctaaa gagttaattc taattattcc gatatgacct taaggaaaag     3660

taaaggaata aatttttgtc tttgttgaag tatttaatag agtaaggtaa agaagatatt     3720

aagtcccttt caaaatggaa aattaattct aaactgagaa aaatgttcct actacctatt     3780

gctgatactg tctttgcata aatgaataaa aataaacttt ttttcttcaa a              3831


<210> 2166
<211> 2382
<212> DNA
<213> Homo sapiens

<400> 2166
ctttgaccac tcgaagcccc acagcgtgtt ccagcggact tcaccagcag acccagaagt       60

ggtgggtgaa acactgcctc tgttcctcct tgagcctgtc gggagctgct gcctgccacc      120

accatgtctg ctgcaaatcc tgagactcca aactcaacca tctccagaga ggccagcacc      180

cagtcttcat cagctgcagc tagccaaggc tgggtgttac cagaaggcaa aatcgtgcca      240

aacactgttt ttgttggtgg aattgatgct aggatggatg aaactgagat tggaagctgc      300

tttggtagat acggttcagt gaaagaagtg aagataatca cgaatcgaac tggtgtgtcc      360

aaaggctatg gatttgtttc gtttgttaat gacgtggatg tccagaagat agtaggatca      420

cagatacatt tccatggtaa aaagctgaag ctgggccctg caatcaggaa acaaaagtta      480

tgtgctcgtc atgtgcagcc acgtcctttg gtagttaatc ctcctcctcc accacagttt      540

cagaacgtct ggcggaatcc aaacactgaa acctacctgc agccccaaat cacgccgaat      600

cctgtaactc agcacgttca gtctgctgca aatcctgaga ctccaaactc aaccatctcc      660

agagaggcca gcacccagtc ttcatcagct gcagctagcc aaggctgggt gttaccagaa      720

ggcaaaatcg tgccaaacac tgtttttgtt ggtggaattg atgctaggat ggatgaaact      780

gagattggaa gctgctttgg tagatacggt tcagtgaaag aagtgaagat aatcacgaat      840

cgaactggtg tgtccaaagg ctatggattt gtttcgtttg ttaatgacgt ggatgtccag      900

aagatagtag gatcacagat acatttccat ggtaaaaagc tgaagctggg ccctgcaatc      960

aggaaacaaa agttatgtgc tcgtcatgtg cagccacgtc ctttggtagt taatcctcct     1020

cctccaccac agtttcagaa cgtctggcgg aatccaaaca ctgaaaccta cctgcagccc     1080

caaatcacgc cgaatcctgt aactcagcac gttcagtctg ctgcaaatcc tgagactcca     1140

aactcaacca tctccagaga ggccagcacc cagtcttcat cagctgcagc tagccaaggc     1200

tgggtgttac cagaaggcaa aatcgtgcca aacactgttt ttgttggtgg aattgatgct     1260

aggatggatg aaactgagat tggaagctgc tttggtagat acggttcagt gaaagaagtg     1320

aagataatca cgaatcgaac tggtgtgtcc aaaggctatg gatttgtttc gtttgttaat     1380

gacgtggatg tccagaagat agtaggatca cagatacatt tccatggtaa aaagctgaag     1440

ctgggccctg caatcaggaa acaaaagtta tgtgctcgtc atgtgcagcc acgtcctttg     1500

gtagttaatc ctcctcctcc accacagttt cagaacgtct ggcggaatcc aaacactgaa     1560

acctacctgc agccccaaat cacgccgaat cctgtaactc agcacgttca ggcttactct     1620

gcttatccac attcaccagg tcaggtcatc actggatgtc agttgcttgt atataattat     1680

caggaatatc ctacttatcc cgattcagca tttcaggtca ccactggata tcagttgcct     1740

gtatataatt atcagccatt tcctgcttat ccaagatcac catttcaggt cactgctgga     1800

tatcagttgc ctgtatataa ttatcaggca tttcctgctt atccaaattc accatttcaa     1860

gtcgccactg gatatcagtt ccctgtatgt gaaatttgca aaatactggt attaaagaac     1920

gctgcagctt ttttatgtca ctcaaaggtt aatcggagta tctgaaagga attgttttta     1980

taaaaacatt gaagtattag ttacttgcta taaatagatt tttatttttg ttttttagcc     2040

tgttatattt ccttctgtaa aataaaatat gtccagaaga ggcatgttgt ttctagatta     2100

ggtagtgtcc tcattttata ttgtgaccac acagctagag caccagagcc cttttgctat     2160

actcacagtc ttgttttccc agcctctttt actagtcttt caggaggttt gctcttagaa     2220

ctggtgatgt aaagaatgga agtagctgta tgagcagttc aaaggccaag ccgtggaatg     2280

gtagcaatgg gatataatac ctttctaagg gaaacatttg tatcagtatc atttgatctg     2340

ccatggacat gtgtttaaag tggctttctg gcccttcttt ca                        2382


<210> 2167
<211> 1584
<212> DNA
<213> Homo sapiens

<400> 2167
ttcgccgtta ctctgcgcgt aagtcgcttg tccgtggctt ctctgagaag aaaagttgaa       60

aaagggtaaa agttttcagg aatattcggg ctctctattg ctaagcatag cgagtgtcgg      120

ttttctctct ccaacagaca tcgctattgc ggttccgagg cagtgggaag agatgcggcc      180

cctggacatc gtcgagctgg cggaaccgga ggaagtggag gtgctggagc ccgaggagga      240

tttcgagcag tttctgctcc cggtcatcaa cgagatgcgc gaggacatcg cgtcgctgac      300

gcgcgagcac gggcgggcgt acctgcggaa ccggagcaag ctgtgggaga tggacaatat      360

gctcatccag atcaaaacgc aggtggaggc ctcggaggag agcgccctca accacctcca      420

gaacccgggc gacgcggccg agggccgggc ggccaagagg tgcgagaagg ccgaggagaa      480

ggccaaggag attgcgaaga tggcagagat gctggtggag ctggtccggc ggatagagaa      540

gagcgagtcg tcgtgagcgc ggtcggcggt ttccagccaa tggattctgg tcaactggtg      600

gagattggct gacaccctgg agaagccgaa accagagagc cttttgtttt ctcttttttc      660

ctgtctatgc tctgtctcac ttaacactac gttttctgct atggtctgtg gttgatgacc      720

tcaatatgag tttcgattgt taacgtgttt ttgtttggga agtaattttg tttgaaaatg      780

ctctcacata caggaattag ggcctagatt gtaagctctt gcagcagtca catttgttcc      840

cgggctttgg tggttatttc taaatttttg aggtgctttg ctatttcttg tgtgacctga      900

tagctccctg gaactttggg tctgtgtgtg acacatgaga ctcacagttg gagttctcca      960

gctctggagg tgctgaagga gctgcattaa ttctggaaga cgactccatg cagcaactac     1020

tgaagaaagg accagacttc aacggggagt gtggatgggc cgacctggct gggactcgtg     1080

aatctggaga agagctggag aatggatagt attgtctgta tttggagact ttaatttctg     1140

tgtgagacca aaggaggaga gatgtgtttt gttcaaaatt taaatttgtt gtggtacact     1200

atcttatgta acctgtctgg tgagtttgtt tggacaacct aactcagctt tatttgacat     1260

ggaacctaaa atagaagata agatcttgat attctgtaca agttgatgta ataccctgat     1320

gcgttttaga ggacttggca taaaatgaaa gattggcaaa ggcccttgag gggcttgggg     1380

atgacagtat ggaactgtct gcattggacc ctaaactgga ctagaagagg catcttcaag     1440

gttcatacgt tgtccagctg taagttcatt tgagtagcag acctaacaaa tatttgaggt     1500

cagaacccta ccatgttaaa acaaacaaaa acttaccatg ttaataaaag tattcatttg     1560

cttgaaaaga cgaaagacct aaaa                                            1584


<210> 2168
<211> 936
<212> DNA
<213> Homo sapiens

<400> 2168
agctgcacag ggccgcacta aagtcatact cacactaccc tgggggactg gtttctggac       60

aaggtgttga gaaagggaga aaactcttcc ttttaggatg gtgaggaagg aaagccggtc      120

tgaactggat gatgagggcc atgaagcccc caggaggaga atcgagcaat ctttttggaa      180

gtccagaaga agctactcct tccagcaggc ctaataggat ggcatctaat atttttggac      240

caacagaaga acctcagaac atacccaaga ggacaaatcc cccagggggt aaaggaagtg      300

gtatctttga cgaatcaacc cccgtgcaga ctcgacagca cctgaaccca cctggaggga      360

agaccagcga catttttggg tctccggtca ctgccacttc acgcttggca cacccaaaca      420

aacccaagga tcatgttttc ttatgtgaag gagaagaacc aaaatcggat cttaaagctg      480

caaggagcat cccggctgga gcagagccag gtgagaaagg cagcgccaga aaagcaggcc      540

ccgccaagga gcaggagccc atgcccacag tcgacagcca tgagccccgg ctggggccgc      600

ggcctcgctc tcacaacaag gtcctgaacc caccgggagg caaatccagc atctccttct      660

actaagagaa gccactgctc cacccggagc cagaccagaa actcaagaga tagggtagcc      720

atgttttcat ttccttttgc ccaaatgagc ggggtgggaa gagggttagt cttatgtgag      780

cctggctgct cagcgtctcc tggccgtcat gacagctgct tggagacccg tgccttccag      840

atggctggga gatgcctctg tggggatgaa atggggcacc cctggccatc actcatgtgt      900

agtccaggtt tgagaggaac tggaaggggg gtgagg                                936


<210> 2169
<211> 965
<212> DNA
<213> Homo sapiens

<400> 2169
acggcgcgcg gcgagctgag ggtggcggcg gtcgacatgt tccaggtccc ggatagcgag       60

ggcggccgcg ccggctccag gaaatggcaa ctgctgacag gaagtttggc atccacctcc      120

cccagcctcc tgagtggaca ggggccctgg gcaccacttc agagggccat gaagccccca      180

ggaggagaat cgagcaatct ttttggaagt ccagaagaag ctactccttc cagcaggcct      240

aataggatgg catctaatat ttttggacca acagaagaac ctcagaacat acccaagagg      300

acaaatcccc cagggggtaa aggaagtggt atctttgacg aatcaacccc cgtgcagact      360

cgacagcacc tgaacccacc tggagggaag accagcgaca tttttgggtc tccggtcact      420

gccacttcac gcttggcaca cccaaacaaa cccaaggatc atgttttctt atgtgaagga      480

gaagaaccaa aatcggatct taaagctgca aggagcatcc cggctggagc agagccaggt      540

gagaaaggca gcgccagaaa agcaggcccc gccaaggagc aggagcccat gcccacagtc      600

gacagccatg agccccggct ggggccgcgg cctcgctctc acaacaaggt cctgaaccca      660

ccgggaggca aatccagcat ctccttctac taagagaagc cactgctcca cccggagcca      720

gaccagaaac tcaagagata gggtagccat gttttcattt ccttttgccc aaatgagcgg      780

ggtgggaaga gggttagtct tatgtgagcc tggctgctca gcgtctcctg gccgtcatga      840

cagctgcttg gagacccgtg ccttccagat ggctgggaga tgcctctgtg gggatgaaat      900

ggggcacccc tggccatcac tcatgtgtag tccaggtttg agaggaactg gaaggggggt      960

gaggg                                                                  965


<210> 2170
<211> 5428
<212> DNA
<213> Homo sapiens

<400> 2170
ggcccaccgc cgcccaggca aggccgccct gccttgggcg cagcgctgcc atggctgggg       60

gccgtggggc ccccgggcgc ggccgggacg agcctccgga gagctacccg caacgacagg      120

accacgagct acaggccctg gaggccattt acggcgcgga cttccaagac ctgcggccgg      180

acgcttgcgg accggtcaaa gagccccctg aaatcaattt agttttgtac cctcaaggcc      240

taactggtga agaagtatat gtaaaagtgg atttgagggt taaatgccca cctacctatc      300

cagatgtagt tcctgaaata gagttaaaaa atgccaaagg tctatcaaat gaaagtgtca      360

atttgttaaa atctcgccta gaagaactgg ccaagaaaca ctgtggggag gtgatgatct      420

ttgaactggc ttaccacgtg cagtcatttc tcagcgagca taacaagccc cctcccaagt      480

cttttcatga agaaatgctg gaaaggcggg ctcaggagga gcagcagagg ctgttggagg      540

ccaagcggaa agaagagcag gagcaacgtg aaatcctgca tgagattcag agaaggaaag      600

aagagataaa agaagagaaa aaaaggaaag aaatggctaa gcaggaacgt ttggaaattg      660

ctagtttgtc aaaccaagat catacctcta agaaggaccc aggaggacac agaacggctg      720

ccattctaca tggaggctct cctgactttg taggaaatgg taaacatcgg gcaaactcct      780

caggaaggtc taggcgagaa cgtcagtatt ctgtatgtaa tagtgaagat tctcctggct      840

cttgtgaaat tctgtatttc aatatgggga gtcctgatca gctcatggtg cacaaaggga      900

aatgtattgg cagtgatgaa caacttggaa aattagtcta caatgctttg gaaacagcca      960

ctggtggctt tgtcttgttg tatgagtggg tccttcagtg gcagaaaaaa atgggtccat     1020

tccttaccag tcaagaaaaa gagaagattg ataagtgcaa aaagcagatt caaggaacag     1080

aaacagaatt caactcactg gtaaaattga gccatccaaa tgtagtacgc taccttgcaa     1140

tgaatctcaa agagcaagac gactccatcg tggtggacat tttagtggag cacattagtg     1200

gggtctctct tgctgcacac ctgagccact caggccccat ccctgtgcat cagcttcgca     1260

ggtacacagc tcagctcctg tcaggccttg attatctgca cagcaattct gtggtgcata     1320

aggtcctgag tgcatctaat gtcttggtgg atgcagaagg caccgtcaag attacggact     1380

atagcatttc taagcgcctc gcagacattt gcaaggagga tgtgtttgag caaacccgag     1440

ttcgttttag tgacaatgct ctgccttata aaacggggaa gaaaggagat gtttggcgtc     1500

ttggccttct gctgctgtcc ctcagccaag gacaggaatg tggagagtac cctgtgacca     1560

tccctagtga cttaccagct gactttcaag attttctaaa gaaatgtgtg tgcttggatg     1620

acaaggaaag atggagtccc cagcagttgt tgaaacacag ctttataaat ccccagccaa     1680

aaatgcctct agtggaacaa agtcctgaag attctgaagg acaagattat gttgagactg     1740

ttattcctag caaccggcta cccagtgctg ccttctttag tgagacacag agacagtttt     1800

cccgatactt cattgagttt gaagaattac aacttcttgg taaaggagct tttggagctg     1860

tcatcaaggt gcagaacaag ttggacggct gctgctacgc agtgaagcgc atccccatca     1920

acccggccag ccggcagttc cgcaggatca agggcgaagt gacactgctg tcacggctgc     1980

accatgagaa cattgtgcgc tactacaacg cctggatcga gcggcacgag cggccggcgg     2040

gaccggggac gccgcccccg gactccgggc ccctggccaa ggatgaccga gctgcacgcg     2100

ggcagccggc gagcgacaca gacggcctgg acagcgtaga ggccgccgcg ccgccaccca     2160

tcctcagcag ctcggtggag tggagcactt cgggcgagcg ctcggccagt gcccgtttcc     2220

ccgccaccgg cccgggctcc agcgatgacg aggacgacga cgaggacgag cacggtggcg     2280

tcttctccca gtccttcctg cctgcttcag attctgaaag tgatattatc tttgacaatg     2340

aagatgagaa cagtaaaagt cagaatcaga tggagtactg tgagaagagc actttacgag     2400

acaccattga ccagggactg tatcgagaca ccgtcagact ctggaggctt tttcgagaga     2460

ttctggatgg attagcttat atccatgaga aaggaatgat tcaccgggat ttgaagcctg     2520

tcaacatttt tttggattct gatgaccatg tgaaaatagg tgattttggt ttggcgacag     2580

accatctagc cttttctgct gacagcaaac aagacgatca gacaggagac ttgattaagt     2640

cagacccttc aggtcactta actgggatgg ttggcactgc tctctatgta agcccagagg     2700

tccaaggaag caccaaatct gcatacaacc agaaagtgga tctcttcagc ctgggaatta     2760

tcttctttga gatgtcctat caccccatgg tcacggcttc agaaaggatc tttgttctca     2820

accaactcag agatcccact tcgcctaagt ttccagaaga ctttgacgat ggagagcatg     2880

caaagcagaa atcagtcatc tcctggctgt tgaaccacga tccagcaaaa cggcccacag     2940

ccacagaact gctcaagagt gagctgctgc ccccacccca gatggaggag tcagagctgc     3000

atgaagtgct gcaccacacg ctgaccaacg tggatgggaa ggcctaccgc accatgatgg     3060

cccagatctt ctcgcagcgc atctcccctg ccatcgatta cacctatgac agcgacatac     3120

tgaagggcaa cttctcaatc cgtacagcca agatgcagca gcatgtgtgt gaaaccatca     3180

tccgcatctt taaaagacat ggagctgttc agttgtgtac tccactactg cttccccgaa     3240

acagacaaat atatgagcac aacgaagctg ccctattcat ggaccacagc gggatgctgg     3300

tgatgcttcc ttttgacctg cggatccctt ttgcaagata tgtggcaaga aataatatat     3360

tgaatttaaa acgatactgc atagaacgtg tgttcaggcc gcgcaagtta gatcgatttc     3420

atcccaaaga acttctggag tgtgcatttg atattgtcac ttctaccacc aacagctttc     3480

tgcccactgc tgaaattatc tacactatct atgaaatcat ccaagagttt ccagcacttc     3540

aggaaagaaa ttacagtatt tatttgaacc ataccatgtt attgaaagca atactcttac     3600

actgtgggat cccagaagat aaactcagtc aagtctacat tattctgtat gatgctgtga     3660

cagagaagct gacgaggaga gaagtggaag ctaaattttg taatctgtct ttgtcttcta     3720

atagtctgtg tcgactctac aagtttattg aacagaaggg agatttgcaa gatcttatgc     3780

caacaataaa ttcattaata aaacagaaaa caggtattgc acagttggtg aagtatggct     3840

taaaagacct agaggaggtt gttggactgt tgaagaaact cggcatcaag ttacaggtct     3900

tgatcaattt gggcttggtt tacaaggtgc agcagcacaa tggaatcatc ttccagtttg     3960

tggctttcat caaacgaagg caaagggctg tacctgaaat cctcgcagct ggaggcagat     4020

atgacctgct gattccccag tttagagggc cacaagctct ggggccagtt cccactgcca     4080

ttggggtcag catagctata gacaagatat ctgctgctgt cctcaacatg gaggaatctg     4140

ttacaataag ctcttgtgac ctcctggttg taagtgttgg ccagatgtct atgtccaggg     4200

ccatcaacct aacccagaaa ctctggacag caggcatcac agcagaaatc atgtacgact     4260

ggtcacagtc ccaagaggaa ttacaagagt actgcagaca tcatgaaatc acctatgtgg     4320

cccttgtctc ggataaagaa ggaagccatg tcaaggttaa gtctttcgag aaggaaaggc     4380

agacagagaa gcgtgtgctg gagactgaac ttgtggacca tgtactgcag aaactgagga     4440

ctaaagtcac tgatgaaagg aatggcagag aagcttccga taatcttgca gtgcaaaatc     4500

tgaaggggtc attttctaat gcttcaggtt tgtttgaaat ccatggagca acagtggttc     4560

ccattgtgag tgtgctagcc ccggagaagc tgtcagccag cactaggagg cgctatgaaa     4620

ctcaggtaca aactcgactt cagacctccc ttgccaactt acatcagaaa agcagtgaaa     4680

ttgaaattct ggctgtggat ctacccaaag aaacaatatt acagttttta tcattagagt     4740

gggatgctga tgaacaggca tttaacacaa ctgtgaagca gctgctgtca cgcctgccaa     4800

agcaaagata cctcaaatta gtctgtgatg aaatttataa catcaaagta gaaaaaaagg     4860

tgtctgtgct atttctgtac agctatagag atgactacta cagaatctta ttttaaccct     4920

aaagaactgt cgttaacctc attcaaacag acagaggctt atactggaat aatggaatgt     4980

tgtacattca tcataattta aaattaaatt ctaagaagag gctgggtgca gtggctcaca     5040

cctttaatcc cagcactttg ggaagccaag gcaggaagac tgcttgaaac caggagtttg     5100

agaccagcct gagcaacaaa gcaagacccc atctctataa aaactaaaaa aattagttgg     5160

gcatggtggc acatgcctgt agtcccagct actccagagg ctgagatgga tcatctgagc     5220

ctcaggaggt tgaggctgca gtgagctgtg actgcgccac tgcactccag tctgggacaa     5280

cagagcaaga ccctgtctta aaaaaaaaaa gaaaaaaaaa atttttttct aagaagctgt     5340

cctacaaagt tgagctttgt tagtttttca tgtgtaatat attataaatt tatcttttgg     5400

gatataataa atgctttcat atacctgc                                        5428


<210> 2171
<211> 3931
<212> DNA
<213> Homo sapiens

<400> 2171
aaataaaacg gacaccttaa gcgctacaat caaggtgcgc acggggtgct acagaacaat       60

acgcagacag gaggaggtgg ggggaaaggt gagacttccc aggcaggtgt catcccagaa      120

taacttttac acagggtgac taagcgagtt agtgactgcg cggaaaacgg gcttccaagg      180

ttcacaaggc tcgtgctgcg gctccgggag ttatgtcaca gtaagcttac tatcatcctt      240

tgggcatctg ctttacggat gagttcatca ggatttaaag gatcttggtt ccatatcctt      300

ccccttcctc acagaggccg ccagcccgga gcccctctag gccctcctcc ctcctgcatc      360

tactggccgc gagcctttcc ctccccgccc ccttcacaca ggccgccccc agcctcccaa      420

ccccccggtt ccgttccacg ggaggccccg gcctccctgc cctctcctcc accgttctac      480

ccgcatcgcc cggcttcccg caagccgctg gcaccgtccc ctcaacaccc tccgcccacc      540

gccactccct tccactgagg gggaccgggc tgccttctct ctgacccgcc gttctccgcc      600

cccacccact tccccaggcc tcccgcacca cccccttccc gccgcgctct ctcccgcccc      660

cgcgcttccg gccccgcccg cccccgcgcg gaggactgtg ggagcggctt ccttggattc      720

cgcgcttggc aacggctcgg cgtcgcgctt tggccaaccg ctgcgtcgtc cctgggcccg      780

aataactgtc gcccgcttcc ctcagcgtga ggtgaagcac ttcaaattgc ctgatgaaag      840

ttgaatcagg aatgaagata aaagtacaca acaatgcaga aagcggtact tagcctcaca      900

aagatggaaa cattccaaaa acgtgaagta ctgttgtccc aagattcttt ctaagcctaa      960

aattacactt ttactagtcc gattttctgg ttgtgagttt tttttgtttg tttttttttt     1020

ttcgagaaac tgcagtaggc ttcttggaag tagaccaagg gtgtccaatc tttggcttcc     1080

ctgggccaca tcggaagaag aattgtcttg ggccacacat gaaattcaca aacactaagg     1140

tacaaatgat gcaaaatgtg cacctggctc cagagacaga tgaagatgat ctttattccg     1200

gctataatga ctacaatcca atctatgata tcgaggaatt ggagaatgat gcagcttttc     1260

agcaagctgt gaggactagt catggcagaa gacctccaat aactgctaaa atatcaagca     1320

cggcagttac tagacctata gctactggat atgggtccaa gacatctctg gcatcatcaa     1380

taggaagacc aatgacaggg gctattcagg atggagttac tagacccatg acagcagtga     1440

gagcagctgg ttttaccaaa gcagctttga gaggctctgc atttgacccc cttagtcagt     1500

caaggggccc tgcttcccct ttggaagcca agaaaaaaga tagcccagag gaaaaaataa     1560

agcaattaga gaaggaagta aatgagttgg tagaagaaag ctgtattgcc aatagttgtg     1620

gagacttaaa attggcctta gaaaaggcaa aagatgcagg aagaaaagag agagtcctgg     1680

tgagacagcg agaacaagtt acaactccag aaaatatcaa tttggattta acttactcag     1740

ttcttttcaa tttggccagt cagtattcag ttaatgaaat gtatgccgaa gcacttaaca     1800

cttatcaagt tatagtcaaa aataagatgt ttagcaatgc aggaatattg aaaatgaata     1860

tgggaaatat ctatttaaag caaagaaatt attccaaagc cattaaattc taccgaatgg     1920

cattagacca agttccaagt gtcaataagc aaatgaggat taaaataatg cagaatattg     1980

gagttacatt tattcaggct ggtcagtatt cagatgctat taattcatat gagcacataa     2040

tgagcatggc accaaatctg aaggcaggct acaacctaac tatctgttat tttgctattg     2100

gagaccgaga aaaaatgaag aaggcattcc aaaaattgat tactgttcca ttagaaattg     2160

atgaagataa atatatttca ccaagtgatg atcctcatac taacttagta actgaagcta     2220

taaaaaatga tcacctcagg caaatggaac gtgaaaggaa agccatggca gaaaaatata     2280

ttatgacatc tgcaaaactc attgctcctg taattgaaac atcttttgct gcaggttatg     2340

attggtgcgt ggaagtggtg aaagcttctc aatatgtaga gctagccaat gatctggaaa     2400

taaacaaagc agttacatac ttgagacaaa aagactataa ccaagctgta gagatcttaa     2460

aagtgttgga aaaaaaggac agtagagtga aaagtgcagc tgcaaccaat ctctcagccc     2520

tgtattatat gggaaaggat tttgcacaag ccagcagcta tgcagatata gctgtgaact     2580

ctgatagata taatccagca gctcttacta ataaagggaa tacagttttt gcaaatggtg     2640

attatgagaa ggccgctgaa ttctataaag aggctctaag aaatgattct tcttgtactg     2700

aagcacttta taatattggc cttacctatg agaaactaaa tcggctagat gaggctttgg     2760

actgtttcct gaaacttcac gcaatcctac gaaacagtgc cgaagttctt taccagatag     2820

caaatatata tgaattaatg gaaaatccca gtcaagctat tgaatggcta atgcaggtgg     2880

tcagtgttat tccaaccgat cctcaagttt tatctaagct aggagaatta tatgatcgtg     2940

aaggagataa atctcaagca tttcaatatt actatgagtc atataggtat tttccttgta     3000

atattgaagt cattgagtgg cttggagcct attacattga cacccaattt tgggaaaaag     3060

ctattcagta ctttgaaaga gcttctctta tacagcctac acaagtgaaa tggcagctga     3120

tggtagctag ttgtttcaga agaagtggta actaccaaaa agcattagat acttacaaag     3180

atactcacag aaaatttcca gaaaatgtcg aatgttctgg cagcgtgagg acaggacaca     3240

tggagagaga ccctttaaac ctccttccaa ggaagtcagt tctccctggt ccagagattg     3300

caaagtgtaa ttatttttca ggagaaaaat actatttgtc tgcgtttctt agttcgtctc     3360

tgcacagatc ttggattaaa agatgctcaa gaatatgcca gaaaactgaa gaggttggaa     3420

aaaatgaaag aaataaggga acagcgcata aagtcaggca gagatggcag tgggggctcc     3480

cgtggcaaaa gagaaggaag tgctagcggt gatagtggcc agaactatag tgccagtagt     3540

aaaggtgaac gactaagtgc cagactcaga gctttacctg ggacaaatga accttatgaa     3600

agtagcagta acaaagaaat agatgcctcc tatgtggacc cacttggccc tcaaatagaa     3660

cgaccaaaaa ctgcagccaa gaaaaggatc gatgaggatg attttgctga tgaagaatta     3720

ggagatgatt tgcttccaga ataatattca ctttaatatt tattaaagga aagaaattgc     3780

cttatgagat catcctcatg ttaaaccttg gattaaatat ctaacctgta attatttttt     3840

ttcactgtca aaacttaagt aagtgtattc tattctgtat gtatgcattt aagttgtttt     3900

tttcttttaa ggaataaaaa caggtaaaac t                                    3931


<210> 2172
<211> 318
<212> DNA
<213> Homo sapiens

<400> 2172
ttgacctcca aacacatcta cagttgctga accatgagct actacagaag ctattatgga       60

ggcctgggct atggctatgg aggctttggt ggctggggct atggctatgg ctgcggctat      120

ggcagcttcc gcaggttggg ctatggctgt ggctacggag gctatggatt cagctgttgc      180

cgaccattat actacggagg atatggattc tctgccttct actgaagagt gaactcattc      240

tttggatcac tagaatctgt ctatcatcct gacttaattc tcctttcagg tctttttacc      300

ccctctgtga attgcgca                                                    318


<210> 2173
<211> 273
<212> DNA
<213> Homo sapiens

<400> 2173
ggctagagac ttaaatcctg acacaatgag ctactatggc aactactacg gaggactggg       60

ctatggctat gactgtaaat atagttatac ctctggcttt ggtgccttta gaatcctgga      120

ctgtggctac agatgtggct gtggtggggt atggatttga ctgctgccac caatatgatt      180

atgctacatg cttattatca ggcactgact gaataatatc tacaattggg tccattttct      240

tatgagacag gggtgctgtt ctactacact ttt                                   273


<210> 2174
<211> 224
<212> DNA
<213> Homo sapiens

<400> 2174
tccacaactg aaacatccac ttctgaacac catgtcctac tacagccatc tttctggtgg       60

cctgggctgc ggcttggctg tggctgtgac tatgggaagg actgtggctg tggctgagta      120

tggcaggtgc agacatggct gccactcatc ttactctgcc aggtaatgac accatggatt      180

ccactgagga acacctagag cagttcagtc tactgcactc ctcc                       224


<210> 2175
<211> 293
<212> DNA
<213> Homo sapiens

<400> 2175
attgaactcc atcttctgac accatgtgct actaccacaa ctattatggt agcctggact       60

atggttgcag ctatggctct gaatatggta actctggata tgcctgcaac tttccgtgct      120

cctatggaag attcctattg gctcctagaa agaaattctg attgctgatc actttgagcc      180

attttcttgt gatgcactaa ttgcatcaac agggttattt atggattcgt tattgtctct      240

ccaattttaa ctaactctaa ttattgatta ccacaggtca tatttgcatt gga             293


<210> 2176
<211> 682
<212> DNA
<213> Homo sapiens

<400> 2176
gaccatcttt aaggattttt agcaatatgc ctcatagcca ctgccattca ctcaggagct       60

tccacaatgc cccaccactc tctgccatca cacatggcac taatcctata acctttgaag      120

acagattgtg tttgcccagc agcttccata gcagaacctg tttcctggac aactttcaag      180

aaacctgcaa tgaaaccacc agctgccaaa tgaccaattg tgaacaggac ttattcacag      240

acgatagctg tgtgcaaagt aactgcttcc ccggagttgt ccaaactact tactccaatt      300

ccaggccctg cgaaaggaca gcgtgccaat cagaaagttc ttcagcaggg ctggcttgtg      360

tttctcagcc ttgccaatca gaaagcactc agcagatggg ttttgtagcc cagagctgcc      420

aacctgcaag cctcaaggga aacagttgcc cacccaagac ttctaagtct aaaaatttcg      480

aaactctgga acgtgcatct agccaatgtc agtgtcagtc tcagaaccct gaatccagtt      540

cctgtagacc tctggtcaat gttgcacctg agccacaact cctggaatct tctccaggag      600

ttgaaccaac ttgctgtgtt actggtggtt ctcaattgcc tagtaagtga agatctgtag      660

gggagatggc ttatattctc at                                               682


<210> 2177
<211> 1390
<212> DNA
<213> Homo sapiens

<400> 2177
agcatttgaa gctgcagtcc tgaaaaccat gcaggccgga agagtagata aagaaatatt       60

tatttgagat ggcacatgtt tcttcagaaa ctcaagatgt ttcccccaaa gatgaattaa      120

ctgcttcaga agcctccact aggtctccat tgtgtgaaca caccttccct ggggactcag      180

acttacggtc aatgattgaa gaacatgctt ttcaggtttt gtcacaagga tccttgttag      240

aaagtccaag ttacacagtt tgtgtctctg agccagataa agatgatgat tttctttctc      300

tgaactttcc caggaaactt tggaaaatag tggaaagtga ccaattcaag tctatttcat      360

gggatgagaa tggaacttgc atagtgatta atgaagaact cttcaagaaa gaaattttgg      420

aaacaaaggc tccttacaga atatttcaaa ctgatgctat caaaagtttt gttcgacagc      480

tcaaccttta tggatttagt aaaattcaac agaattttca aagatctgcc tttctagcca      540

cctttctgtc agaagagaaa gaatcgtctg tcttaagcaa gcttcatgtc tttgtgtttc      600

accacagtct atttggagca acattcggag aacatcactt tcagccatgc cctttaccat      660

ctggtaacaa ggctcccatt tctacttgga gtggagattc ctggttgctg tgatgaaatg      720

ggatacactg gggatccagc tgcacaactt ttcggaagca gcattcactg tggatttggt      780

atattatgca gcttttggtg tcacaggcta aggtctgaca agattcacca tgcagttttc      840

tgggatagca gaaaatgaac atggatttgg acagccagat tcctcaggat ggaaacctag      900

tggtgccatc taaccatata cgtatatttc caagttgtgc ataagtagaa aaagtttaga      960

atccatcatc taaaaaggga atcctgattt cctttcctgg cagaccatga cagaaagaca     1020

aaggtcattt cacctatatc cacatgctat taacttttta gttctcaaac tgggttttca     1080

gaaggtagtg tgatagacat ggttaaatgg ttaacaggaa gaatgtttaa aaaaaaaatt     1140

ccggctgggg tggtggctca ggcctgtaat cacagcattt tgggaggcca agctgagtca     1200

ggagaatcgc ttgaacccag gaggcggagg ttgcagtaag ctgagatcct gcttttgcgc     1260

tccagcctgg gtgacagagt aagacttcat cttaaagaaa tccacaacaa taaaaaggct     1320

aatgccagac acaataaaaa atgaaaagaa taacttgggt gaacagcaag gcaagaaaga     1380

aaaaaggaaa                                                            1390


<210> 2178
<211> 1374
<212> DNA
<213> Homo sapiens

<400> 2178
agcatttgaa gctgcagtcc tgaaaaccat gcaggccgga agagtagata aagaaatatt       60

tatttgagat ggcacatgtt tcttcagaaa ctcaagatgt ttcccccaaa gatgaattaa      120

ctgcttcaga agcctccact aggtctccat tgtgtgaaca caccttccct ggggactcag      180

acttacggtc aatgattgaa gaacatgctt ttcaggtttt gtcacaagga tccttgttag      240

aaagtccaag ttacacagtt tgtgtctctg agccagataa agatgatgat tttctttctc      300

tgaactttcc caggaaactt tggaaaatag tggaaagtga ccaattcaag tctatttcat      360

gggatgagaa tggaacttgc atagtgatta atgaagaact cttcaagaaa gaaattttgg      420

aaacaaaggc tccttacaga atatttcaaa ctgatgctat caaaagtttt gttcgacagc      480

tcaaccttta tggatttagt aaaattcaac agaattttca aagatctgcc tttctagcca      540

cctttctgtc agaagagaaa gaatcgtctg tcttaagcaa gcttcatgtc tttgtgtttc      600

accacagtct atttggagca acattcggag aacatcactt tcagccatgc cctttaccat      660

ctggtaacaa ggctcccatt tctacttgga gtggagattc ctggttgctg tgatgaaatg      720

ggatacactg gggatccagc tgcacaactt ttcggaagca gcattcactg tggatttggt      780

atattatgca gcttttggtg tcacaggcta aggtctgaca agattcacca tgcagttttc      840

tgggatagca gaaaatgaac atggatttgg acagccagat tcctcaggat ggaaacctag      900

tggtgccatc taaccatata cgtatatttc caagttgtgc ataagtagaa aaagtttaga      960

atccatcatc taaaaaggga atcctgattt cctttcctgg cagaccatga cagaaagaca     1020

aaggtcattt cacctatatc cacatgctat taacttttta gttctcaaac tgggttttca     1080

gaaggtagtg tgatagacat ggttaaatgg ttaacaggaa gaatgtttaa aaaaaaaatt     1140

ccggctgggg tggtggctca ggcctgtaat cacagcattt tgggaggcca agctgagtca     1200

ggagaatcgc ttgaacccag gaggcggagg ttgcagtaag ctgagatcct gcttttgcgc     1260

tccagcctgg gtgacagagt aagacttcat cttaaagaaa tccacaacaa taaaaaggct     1320

aatgccagac acaataaaaa atgaaaagaa taacttgggt gaacagcaag gcaa           1374


<210> 2179
<211> 1586
<212> DNA
<213> Homo sapiens

<400> 2179
gtttccggtt cgcctccgga gccatggcgg cggcactgaa gtgtctactg acattaggaa       60

gatggtgccc cggccttgga gtggctcccc aggcccgggc gctcgccgcc ttagtacccg      120

gagtgaccca ggtagataac aagtccggtt tcctgcagaa gaggcctcat cgccagcacc      180

ctggcatcct aaagctgccg cacgtgcggc tgccacaggc actggctaac ggtgcccagt      240

tattgctact tgggagcgct gggcccacta tggagaatca ggtgcaaaca ctgaccagtt      300

atctctggag cagacatttg cctgtagagc cagaggagtt gcaaagacgg gctaggcatc      360

ttgagaaaaa attcctggaa aacccagact tatctcagac agaggagaaa cttcgtggag      420

cagtgctaca cgcactacgt aaaactacct accattggca agaactgagc tacactgagg      480

gactgagcct ggtgtatatg gcagcaagac tggatggtgg ctttgcagca gtctccagag      540

cattccatga gatccgggct cgaaatccag catttcagcc acaaactttg atggactttg      600

gctcaggtac tggttctgtc acctgggctg ctcacagtat ttggggccag agcctacgtg      660

aatatatgtg tgtggacaga tcagctgcca tgttggtttt ggcagaaaaa ctactgaaag      720

gtggttcaga atctggggag ccttatattc caggtgtctt tttcagacag tttctacctg      780

tatcacccaa ggtgcagttt gatgtagtag tgtcagcttt ttccttaagt gaactgccca      840

gcaaggctga ccgcactgag gtagttcaaa ccttatggcg taagacaggt catttcctgg      900

tactggtgga gaatggaaca aaagctgggc acagccttct catggatgcc agggatctgg      960

tccttaaggg aaaagagaag tcacctttgg accctcgacc tggttttgtc tttgccccgt     1020

gtccccatga actcccttgt ccccagttga ccaacctggc ctgtagcttc tcacaggcgt     1080

accatcccat ccccttcagc tggaacaaga aaccaaagga agaaaagttc tctatggtga     1140

tccttgctcg ggggtctcca gaggaggctc atcgctggcc ccgtatcact cagcctgtcc     1200

ttaaacggcc tcgccatgtg cattgtcact tgtgctgtcc agatgggcac atgcagcatg     1260

ctgtgctcac agcccgccgg cacggcaggt atggggggtg tgaccaaaat cagtgggatg     1320

tggcaggaag ctgcagccca cgccagcatc tgtttccaca gggatttgta tcgttgtgcc     1380

cgtgtcagct cctggggaga tcttttacct gtgcttactc cgtctgcgtt tcctccatct     1440

acggctcagg atccctctga gagttgatga ggatgtgtaa caagtatttt cttctatcgt     1500

gcctgccagg gctgaagctg cctggtatcc aggaggggaa tgctggtatc cccatatgtc     1560

tgtgtttgtt tgagattttt aataat                                          1586


<210> 2180
<211> 1717
<212> DNA
<213> Homo sapiens

<400> 2180
gtgcggtgtg gggcaccggg cggggccgcg ggaaccggcg ccccacggag ctgctgctgt       60

cagaccaacc ccgggccccc atcatcactg cgccgcgctt tcaggcgccg agaactaccg      120

ttcccggcat gccatgaaat tggcctcggc gctgaggcgg ggtccggccc tccacccgct      180

cccgccgcgc gcgaatcgcg gtcgcgagcc atggaggagg aggcatcgtc cccggggctg      240

ggctgcagca agccgcacct ggagaagctg accctgggca tcacgcgcat cctagaatct      300

tccccaggtg tgactgaggt gaccatcata gaaaagcctc ctgctgaacg tcatatgatt      360

tcttcctggg aacaaaagaa taactgtgtg atgcctgaag atgtgaagaa cttttacctg      420

atgaccaatg gcttccacat gacatggagt gtgaagctgg atgccagtga tgatcagcca      480

gagaagcctc actttgactc tcgcagtgtg atatttgagc tggattcatg caatggcagt      540

gggaaagttt gccttgtcta caaaagtggg aaaccagcat tagcagaaga cactgagatc      600

tggttcctgg acagagcgtt atactggcat tttctcacag acacctttac tgcctattac      660

cgcctgctca tcacccacct gggcctgccc cagtggcaat atgccttcac cagctatggc      720

attagcccac aggccaagca atggttcagc atgtataaac ctatcaccta caacacaaac      780

ctgctcacag aagagaccga ctcctttgtg aataagctag atcccagcaa agtgtttaag      840

agcaagaaca agatcgtaat cccaaaaaag aaagggcctg tgcagcctgc aggtggccag      900

aaagggccct caggaccctc cggtccctcc acttcctcca cttctaaatc ctcctctggc      960

tctggaaacc ccacccggaa gtgagcaccc ctccctccaa ctccctacca gctccagagt     1020

ggtggtttcc atgcacagat ggccctaggg gtgacctcca gttttgcgtg tggaccgtag     1080

gcctctttct agttgaatga ccaaaattgt aaggctttta gtcccaccga cattagccag     1140

gctcgtagtg aggcctccag agcaggttgt gctgtcccct gcctctggaa gcaatgggga     1200

atttggaatc ttgtgtaagt gcccaaataa gtctgagtgc tttcctcttc ttcaacactc     1260

aaccctcaat cccttagcac tgattgatta gagaggtccc ccaaagaaac cactggtttt     1320

gacccatgaa gcattagaac tgcattgttc attcaggagc cactagtcac atatgactat     1380

ttaaatttaa agtaaattgt atgaaaaatt catttcttca attgcattag ccacattttg     1440

agtattcatg tggctggtag attctgtatt agcacaaaga tatggaacat ttccatcacc     1500

acagaaagtt ctgttggaca gcactgcatt agaatatttt catactgctc ttcctcaatt     1560

aatttttgtt gttaatgttg atgtcttcat tggatgggtc ataatgttcc atgaaacctc     1620

tcaagtacac aattgtatgt tctttgtatc ccttaccaca aatatctcgc tctgctcatt     1680

tcttttgcag cttcctataa agtttgtctt cctcatc                              1717


<210> 2181
<211> 2133
<212> DNA
<213> Homo sapiens

<400> 2181
ggctttcctg gcaggcctgg cgggggggcc aggttgccat gacgaccgcg gctaggtcgc       60

ggcagactcg agccatgggc agcaggaaga aggaaattgc cctgcaggct ggaatgcagc      120

ggcatgatct catctcagtg caacctccac ctctcacgtt caagcagttc tcatgtctca      180

gcctcccgag tagctggtaa aacaggtcaa catcagcacc caagagcttt gggaggaaat      240

gctcagttcc aaaggactaa ctgttgttga tgtctatcaa ggctggtgtg gcccctgcaa      300

acctgtggtg agcctcttcc agaagatgag gatcgaggtc ggcctggacc ttctgcactt      360

tgcattagca gaggcagatc gtcttgatgt cctcgaaaag tacagaggga agtgcgagcc      420

aacctttctg ttttatgcaa ttaaagatga ggctctttct gatgaagatg aatgtgtttc      480

ccatggaaag aataatggtg aagatgagga catggtttca tcagagagga cctgtacctt      540

ggccatcatt aaaccagatg cagtggccca tggaaagact gatgagatta tcatgaagat      600

tcaggaagct gggtttgaaa ttctaacaaa tgaagagaga accatgacag aggcagaagt      660

gcgacttttc taccaacaca aagctggaga ggaggcattt gagaagctgg tacatcacat      720

gtgcagtgga ccaagccacc tcctgatcct caccaggact gagggcttcg aggacgtggt      780

cactacctgg cgaaccgtca tgggcccccg tgaccccaat gtggccagga gggagcagcc      840

agaaagtctc cgagctcagt acggcacaga aatgcccttc aatgccgtcc atggaagccg      900

ggacagagaa gatgctgaca gagaactggc attgctcttc cccagtttga aattttcaga      960

caaagataca gaagcccctc agggtgagtc cagtacacag ccaaggttga agatcactga     1020

cctagactaa aatgagagga ttcagaagtc tgaccttaga acatgagaga gtggaaaacc     1080

tcaggatgtt tcagccaaac aagaagagaa gaaaatattg ttgaaattaa caatgatcag     1140

ggaaaatatc atctattaag aacagggaac cacattttag ctgtagatta ggaatggtaa     1200

tttttatctg gtgttttagt ttccaaaaca tttacatatt gatctactcc tcgccctaga     1260

ccaaacctaa ttccattctt actgatatgc acaatcactc tctgtcctca ttgtcacctc     1320

tagcccctaa attcctccct ttctcagtct acctactctt tgtgactccc tcatatcttt     1380

tccccctggc atggatgtcc tgctcagaca ctccacttag aagacagttt ccctttttca     1440

ctgtcctccc accattcatt actcctcctc cagataccaa ctgctgatgt tgctctagaa     1500

aaaccaccaa acatgactgt tctttccgtg taagctatcc cacctcagcg gcaccctcac     1560

tgctggtgac cagccttgta accccctgga gatgcccatg ttccttatgg tagctacctc     1620

ttacttcaaa ttcttctgcc tccctcatgc tcgcagccac tctgtgccca cctcatcttc     1680

gtagggacct tgattttggg gacacacatt gcaacttccc acttctgacg aaaggtctcc     1740

atgcttttgc tgttttcttt actcttgtca aggttgggta cttcaagctc aaagcctatc     1800

taccttgatc caaaaactac ctttccataa tgttctcaca tctttactct gtcctacctc     1860

tcattttcaa tcctgtttaa aagacgttta agtgtccaaa ctttaacctc ttgaagctag     1920

tcctctcccc actttccatc tttaaatggg catatataca ataaaggctc tgtccatctc     1980

catctcttat atataacaat actgtgactt aaaaaccaac tcagtattgg aaattttcta     2040

aagttctgtc ctagagttct ttcctgacct ctagctccat acttctgatt gcctaataaa     2100

tatgacatgg atgttcagtg gaacttccca tct                                  2133


<210> 2182
<211> 521
<212> DNA
<213> Homo sapiens

<400> 2182
gtttattact actgaaggaa gaacgtgagt agatcagaaa agggagctca ggtaccttcc       60

agagagtgag acccagcgcc cttgtctcgc acccagtagg ctttcatccc cgccatggcg      120

gagctgatcc agaagaagct acagggagaa gtggagaaat atcaacagct acagaaggac      180

ttaagtaaat ccatgtcggg gaggcagaaa cttgaagcac aactaacaga aaataatatc      240

gtgaaagagg aactggccct gctggatggg tccaacgtgg tctttaaact tctgggtccg      300

gtgctagtca aacaggagct gggggaggct cgggccacag tagggaagag gctggactat      360

atcacagctg aaattaagcg atacgaatcc cagcttcggg atcttgagcg gcagtcagag      420

caacagaggg agacccttgc tcagctgcag caggagttcc agcgggccca ggcagcaaag      480

gcaggggctc ctggcaaggc ctgaccccat ggtgggggga g                          521


<210> 2183
<211> 2028
<212> DNA
<213> Homo sapiens

<400> 2183
gttcatttgc tcgcgtgcag gggaagtctg gagaaggcat tgtttcaatt attaaaagtg       60

tgggggcagt gggcggaaca aacgcgccga ctacagaggc tggacgtaag cttagcggtg      120

gcgcgcgtgc gcagcgccgg cccgagttgc caaaacaaag gggatttggt gatggaggct      180

ttgttagaag gaatacaaaa tcgagggcat ggtgggggat ttttgacatc ttgtgaagca      240

gaactacagg agctcatgaa acagattgac ataatggtgg ctcataaaaa atctgaatgg      300

gaaggacgta cacatgctct agaaacttgc ttgaaaatcc gtgaacagga acttaagagt      360

cttaggagtc agttggatgt gacacataag gaggttggaa tgttgcatca gcaggtagaa      420

gaacatgaaa aaatcaagca agagatgacc atggaatata agcaggagtt gaagaaacta      480

catgaagaat tatgcatact gaagagaagc tatgaaaagc ttcagaaaaa gcaaatgagg      540

gaattcagag gaaataccaa aaatcacagg gaagatcggt ctgaaattga gaggttaact      600

gcaaaaatag aggaattccg tcagaaatcg ctggactggg agaagcaacg cttgatttat      660

cagcaacagg tatcttcact ggaggcacaa aggaaggctc tggctgaaca atcagagata      720

attcaggctc agcttgtcaa tcggaaacag aaattagagt ctgtggaact ttctagccaa      780

tcagaaattc aacacttaag cagtaaactg gagcgggcta atgacactat ctgtgccaat      840

gagttggaaa tagagcgcct caccatgagg gtcaatgact tggttggaac cagtatgact      900

gtcctacagg agcagcagca aaaagaagaa aaattgaggg aatctgaaaa actattagag      960

gctctgcagg aagaaaagag agaattgaag gcagctcttc agtctcaaga aaatctcata     1020

catgaggcca gaatacaaaa ggagaagtta caagaaaaag taaaggcaac taacactcaa     1080

catgctgtag aagctataag gccacgggaa gaatctctgg cagaaaagaa gtacacctct     1140

caagggcagg gggacttaga cagtgtgctc tcccagttga attttaccca tactagtgag     1200

gaccttctgc aggcagaggt gacttgtctt gaaggcagtt tggaatctgt gagtgcaacg     1260

tgtaaacagc tgagccaaga actaatggaa aaatatgaag aactgaagag gatggaagca     1320

cataacaatg aatacaaagc agagattaag aagttgaaag aacagatttt acagggtgaa     1380

caaagttaca gttctgcact agaaggaatg aagatggaaa tctcccatct aactcaggag     1440

ttacatcagc gagatatcac tattgcttcc accaaaggtt cttcctcaga catggaaaag     1500

cgactcagag cagagatgca aaaggcagaa gacaaagcag tagagcataa ggagattttg     1560

gatcagctgg agtcactcaa attagaaaat cgtcatcttt ctgaaatggt gatgaaattg     1620

gaattgggtt tacatgagtg ttccttgcct gtatctcccc ttggttcaat agctaccaga     1680

tttttggaag aggaggaact gaggtctcat cacattctag agcgcttgga tgcccatatt     1740

gaagaactaa aaagagagag tgaaaagaca gtgagacaat tcacagcctt aaagtagcct     1800

cttaaaaaaa tcactatctt ggaaataaaa ataaacacca aagagttact gtcatctgaa     1860

gtagcagctc tttaaaaaca tgaagagata aaattataaa aatgatacat ctaaagcagt     1920

ggtgaagaaa gctgaaaaac tgatactttt gataggcatt ttctctgcac tggtttgttt     1980

aaaggacttc ttccagcaat aagttgaaag aataaaccac tttgctag                  2028


<210> 2184
<211> 1476
<212> DNA
<213> Homo sapiens

<400> 2184
gaaagagcag aagaggaggt ggggtggagg gagcagagcc agggattagg ggactactga       60

ggctctggag atgagaccgc caggagtcct tccccaccat gagccccctc cactcctgca      120

gctggaggag tttttcccag tctcagtgct gccctggggc gagagagact gaacaagctg      180

tttgggtggg aagagaatgg aggaagttga cagggatggg cggggcccgt gggggggctg      240

accaggaacc cagcttcctg ctcagtaccc aggcatccag cccccagctc acccccaccc      300

cttccagccc ccactcccct caggaaccca aggttccagc cctcctccca aatcccagcc      360

acccctcccc caccagtttc tcccctctag gggatggagg ctgagagacc ccaggaagaa      420

gaggatggtg agcagggccc ccctcaggat gaggaaggct ggccccctcc aaactccacc      480

actcggcctt ggcgatctgc tcctccatcc cctcctcctc cagggacccg ccacacagcc      540

ctgggacccc gctcggcctc cctgctctcc ctgcagactg aactccttct ggacctggtg      600

gctgaagccc agtcccgccg cctggaggag cagagggcca ccttctacac cccccaaaac      660

ccctcaagcc tagcccctgc cccactccgt cctctcgagg acagagaaca gctttacagc      720

actatcctca gtcaccagtg ccagcggatg gaagcccagc ggtcagagcc tcccctccct      780

ccaggggggc aagagctcct ggagttgctg ctgagagttc agggtggggg tcgaatggag      840

gagcaaaggt cccggccccc cacacacacc tgctgagact tgagccccaa ccagcccttc      900

cttgccactg gtctcaaagc tgggcagccc attgcatgcc ctcaactctt gcttggcagg      960

ggtaccagag actgaaagac acggcacaaa tctcaatatt catctcccac atcaccttcc     1020

ctgggaactg gacagggtga aagtcctcaa actctgggaa caggcgagat ggaacaggga     1080

tttaactccc cgcccacagg tccatgggag cttgaggcag taagggggat cccaggcacc     1140

catctcaagg agtggctggg agtcttttcc ctaacttgtg gggacaccac cagttgtcaa     1200

gctactaggc agtagggtct gagggctcag gcctccacct gagaggttat aacctgagag     1260

acagctctac ccttcctccc agtaagaagg gaaggtgggt gggcacctga gagattaaga     1320

ctattctccc agtcccacta ccagcacccc cgatccctga gactgagggg tttacgggct     1380

gtgaatggac cttcagccct gcccaccctc cctccccact gctgctgagt ctgtctgatg     1440

ttttggttgt gtgaataaat ataattcccc tctgga                               1476


<210> 2185
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 2185
ccggagcggg gatcacctca acttgactgt ggtcccccag ccctccaaga aatgcccata       60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa      120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt      180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt      240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca      300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc      360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc      420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc      480

tcctccatcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc      540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg      600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc      660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg      720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct      780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc      840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc      900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac      960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga     1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg     1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg     1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct     1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc     1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta     1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct     1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat     1440

ataattcccc tctgga                                                     1456


<210> 2186
<211> 4073
<212> DNA
<213> Homo sapiens

<400> 2186
gccagctgct gcgcatgcgc cggccggggc cccgccccca tgcgccgcgc ggctccaggg       60

ccacgttcca gggtcgggtt tggtggattc ctcagtccct gccgccgcgg ggcgccctgg      120

gatagcggcg gggcctcctg gtgagcgcgc gccggggcgg cctccgggaa gtgggagacg      180

ctgcgggtcc tgggcccagg ccttgggatg ggcgggaagg cctggccgcg ccgggctgtg      240

ggcactgcag gaggcccctg tgcaggtgga gatcgccgcg gccctggcgg gactctttgc      300

tggctcttgg gcgcgctgat gcccatcatc tccctgagtt tctgagccct atctctcatg      360

tgtcagtggt caccgccgaa tccagacact ccggccctgt tccggaagag ccctgatatc      420

cgtggctcca tggcgctgtc tgtcgatacc atgcactcta gctctcaagg aggaaaggtt      480

ttgtggaagg gaatagagac ttggaataac agacctgtgc taattagaga cgggaaagat      540

ggaacaaggg gagtgaccct tctccacccc catatcctaa tgtgctctct ctctatccag      600

aacagatctc ggcccctttc caaacactcc tgatgcctca tttgcctctc gcttcttttc      660

gaccaccatt ttgggggctg aggcactcac ggggcctccc caggtttcac tccgtttcta      720

cacagtcgga gccccatgga tctcccatct cccggaggaa ccgtgaagcc aaacagaagc      780

gcctgcgaga gaagcaggct actctggagg ctgagatagc aggggagagc aagtcacctg      840

cagaatccat taaggcctgg aggcctaagg agttagtatt gtatgaaatc cctacgaaac      900

ccggtgaaaa gaaagatgtc tctgggcccc tgcctcctgc atacagcccc cgatatgttg      960

aggctgcctg gtacccgtgg tgggtacgag agggcttctt caaaccagaa tatcaggccc     1020

ggctgcccca agctacaggg gagacctttt ccatgtgtat cccacctccc aatgtcactg     1080

gctccctgca cattggccac gcactcacgg tggccataca ggatgccctc gtgcgctggc     1140

accggatgcg tggggatcaa gtgctgtggg tccctggttc agatcatgca ggaattgcta     1200

cacaagctgt ggtggagaaa caactgtgga aggaacgggg agtgaggaga catgagctga     1260

gccgggaggc cttccttagg gaggtgtggc agtggaagga ggcgaaaggt ggagagatct     1320

gtgagcagct gcgagctctg ggtgcctccc tggactggga tcgagagtgt tttaccatgg     1380

atgttggctc ctcagtggct gtgactgaag cttttgtgcg gctctacaag gcggggttgc     1440

tgtaccggaa ccatcagctt gtcaactggt catgtgcttt aagatcagcc atctcggaca     1500

ttgaggtgga gaaccggccc ctgcctggcc acacacagct tcgactgcct ggctgcccca     1560

cccccgtgtc ttttggcctc ctattttctg ttgccttccc cgtggatgga gagcctgatg     1620

cagaggttgt ggtaggaacc acaaggccag agacgctgcc tggagatgtg gctgtggccg     1680

ttcatccaga cgactcgcga tacacacatc tacacgggcg acagcttcgt caccccttga     1740

tggggcagcc tcttcccctc atcacagact atgctgttca gccacatgtg ggcacggggg     1800

cagtgaaggt gactccagct cacagtcctg ccgatgctga gatgggggcc cgacatggct     1860

tgagcccctt gaatgtcatt gcggaggatg ggaccatgac ctccctctgc ggggactggt     1920

tgcagggtct tcaccggttt gtggcccggg aaaagataat gtctgtgctg agtgaacggg     1980

gcctattccg gggcctccag aaccacccca tggtactgcc catctgcagc cgttctgggg     2040

atgtgataga atacctgctg aagaaccagt ggtttgtccg ctgccaggaa atgggggccc     2100

gagctgccaa ggctgtggag tcgggggccc tggagctcag tccctccttc caccagaaga     2160

actggcagca ctggttttcc catattgggg actggtgtgt ctcccggcag ctgtggtggg     2220

gccatcagat tccagcctac ctggttgtag aggaccatgc gcagggagaa gaggactgtt     2280

gggtggttgg gcggtcagag gctgaggcca gagaggtagc agcggaactg acagggaggc     2340

caggggcaga gctgaccctg gagagggatc ctgatgtcct agacacatgg ttttcttctg     2400

ccctgttccc cttttctgcc ctgggctggc cccaagagac cccagacctt gctcgtttct     2460

accccctgtc acttttggaa acgggcagcg accttctgct gttctgggtg ggccgcatgg     2520

tcatgttggg gacccagctc acagggcagc tgcccttcag caaggtgctt cttcatccca     2580

tggttcggga caggcagggc cggaagatga gcaagtccct ggggaatgtg ctggacccaa     2640

gagacatcat cagtggggtg gagatgcagt tgctgcagga aaagctgaga agcggaaatt     2700

tggaccctgc agagctggcc attgtggctg cagcacagaa aaaggacttt cctcacggga     2760

tccctgagtg tgggacagat gccctgagat tcacactctg ctcccatgga gttcaggcgg     2820

gcgacttgca cctgtcagtc tctgaggtcc agagctgccg acatttctgc aacaagatct     2880

ggaatgctct tcgctttatc ctcaatgctt taggggagaa atttgtgcca cagcctgctg     2940

aggagctgtc tccctcctcc ccgatggatg cctggatcct gagccgcctt gccctggctg     3000

cccaggagtg tgagcggggc ttcctcaccc gagagctctc gctcgtcact catgccctgc     3060

accacttctg gcttcacaac ctctgtgacg tctacctgga ggctgtgaag cccgtgctgt     3120

ggcactcgcc ccgccccctg gggccccctc aggtcctgtt ctcctgcgct gacctcggcc     3180

tccgcctcct ggccccactg atgcccttcc tggctgaaga gctctggcag aggctgcccc     3240

ccaggcctgg ttgcccccct gcccccagca tctcggttgc cccctaccct agcgcctgca     3300

gcttggagca ctggcgccag ccagagctgg agcggcgctt ctcccgggtc caagaggtcg     3360

tgcaggtgct aagggctctc cgagccacgt accagctcac caaagcccgg ccccgagtgc     3420

tgctgcagag ctcagagcct ggggaccagg gcctcttcga ggccttcttg gagcccctgg     3480

gcaccctggg ctactgtggg gctgtgggcc tgttaccccc aggcacagca gctccctccg     3540

gctgggccca ggctccactc agtgacacgg ctcaagtcta catggagctg cagggcctgg     3600

tggacccgca gatccagcta cctctgttag ccgcccgaag gtacaagttg cagaagcagc     3660

ttgatagcct cacagccagg accccatcag aaggggaggc agggactcag aggcaacaaa     3720

agctttcttc cctccagctg gaattgtcaa aactggacaa ggcagcctct cacctccggc     3780

agctgatgga tgagcctcca gccccaggga gcccggagct ctaactcatc atccccatca     3840

gttttcctcc ctctcagacc tgtctttgag gacaaacaga tttgtcagct gtcagggtgc     3900

agtgggacgt cagagactat gtggtccatc gccttcattg tgtaaatgag gacacagact     3960

ggcttggtcg cagtgactgt ggtgtccttg agatgctcac attactgccc ggcctgcctc     4020

ccacctggaa gtctgggaat gaggagattg agataaactt ttgaaatccc aaa            4073


<210> 2187
<211> 3247
<212> DNA
<213> Homo sapiens

<400> 2187
tcaggaatgg agagaagggt aatggtttta cctcttattg tggaaacctg ttgagatcac       60

agagaatata ctgacggcat aaaagggcag aaccatagca gggtgcgcgc tgctgtagtt      120

gccttccatg gatctatagg agagcaagtc ctccaggaga agaagtcctc accagtgaac      180

ggagacctct ctgaactaag gataccatgg ccacgtcagc cccactacgg agcctggaag      240

aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc attgactgtg      300

gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg agccgccccg      360

tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg tggcaactgg      420

ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag ccgggagagg      480

tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag ctgcactact      540

actgtgagga cgacgggaag ctgctgtgcg tgatgtgccg ggagtcccgg gagcacaggc      600

cccacacggc cgtcctcatg gagaaggccg cccagcccca cagggaaaaa atcctgaacc      660

acctgagtac cctaaggagg gacagagaca aaattcaggg cttccaggca aagggagaag      720

ctgatatcct ggccgcgctg aagaagctcc aggaccagag gcagtacatt gtggctgagt      780

ttgagcaggg tcatcagttc ctgagggagc gggaggaaca cctgctggaa cagctggcga      840

agctggagca ggagctcacg gagggcaggg agaagttcaa gagccggggc gtcggggagc      900

ttgcccggct ggccctggtc atctccgaac tggagggcaa ggcgcagcag ccagctgcag      960

agctcatgca ggacacgaga gacttcctaa acaggtatcc acggaagaag ttctgggttg     1020

ggaaacccat tgctcgagtg gttaaaaaaa agaccggaga attctcagat aaactcctct     1080

ctctgcaacg aggcctgagg gaattccagg ggaagctgct gagagacttg gaatataaga     1140

cagtgagcgt caccctggac ccacagtcgg ccagtgggta cctgcagctg tcagaggact     1200

ggaagtgcgt gacctacacc agcctgtaca agagtgccta cctgcacccc cagcagtttg     1260

actgtgagcc tggggtgcta ggcagcaagg gcttcacctg gggcaaggtc tactgggaag     1320

tggaagtgga gagggagggc tggtctgagg atgaagaaga gggggatgag gaggaagagg     1380

gagaagagga ggaggaggaa gaggaggccg gctatgggga tggatatgac gactgggaaa     1440

cggacgaaga tgaggaatcg ttgggcgatg aagaggaaga agaggaggag gaagaggagg     1500

aagttctgga aagctgcatg gtgggggtgg ctagagactc tgtgaagagg aagggagacc     1560

tctccctgcg gccagaggat ggcgtgtggg cgctgcgcct ctcctcctcc ggcatctggg     1620

ccaacaccag ccccgaggct gagcttttcc cagcactgcg gccccggaga gtgggcatcg     1680

ccctggatta tgaagggggc accgtgactt tcaccaacgc agagtcacag gaactcatct     1740

acaccttcac tgccaccttc acccggcgcc tggtcccctt cctgtggctc aagtggccag     1800

gaacacgcct cctgctaaga ccctgagccc tgacatctgc ccccagcccc aaccctcaga     1860

tgcttcactt ctttggaatt ccaggactct caatgggggg acgggatgcc tggcctaagc     1920

acctggagca ggggacccca tatccactgg tagccacctc cccattgctg tggccccctg     1980

aaatctcact cagtgctgtt gctccatcta ctgccctaat ggggctcttt tcccacctcc     2040

tgctggtttc ccgagggaac ttctgaccct ggagtccatg agggctcctt tcctttttga     2100

ccacgacctt ggccccagct ctgcactctc tggaataagg gcccgatgca gcattttctt     2160

gcccagtgtg gcaagacctc agaaaaacca gtcaattacg cctaagatca ttttgctgtc     2220

cttaaacccc ccaggttcct tcttgcacaa atccactctg ctgcccacct tccctggcat     2280

tttaaacaga cctaccccac cccaactcag agttaagcat acatggcaat gctgaaaata     2340

aacaaaatcc actgaggctt cccaggccat ttaaagcctg gagtaccagc gcatatcatc     2400

tcatggggtc cagagtggag tccaggcttc tctgaaacca gggctgagca tatttccata     2460

gccaaggagg tgggactccc tggagctatc tgtggtctta gggaaggatc cagacataca     2520

cggctttggg gtacaagctg tgatcactga tcaataaatt atctctagat tggtccttgt     2580

gaggggagtt ttaagaatcc agaacatctt gctcttgatc agcacatcca aaaacaccaa     2640

gacaaacatc cagtggagca gaacctctcc tgcctcggga gttctgaccg ggttccccag     2700

cagggtgtta agcctctgtc tctggcccta ccagcatcca ggttccactt tcctaggaga     2760

gagtggagat gggaagacag ggaaaggaag gcagcaggag gccacaagcc caccaggtct     2820

tcatgtcaag agagggagta acatgtcttc tcattgccca cggacccaac ctctgtccag     2880

gtgcccctca tcatcacagt ttaacacaag ctcccctgct ccagccaaat tgatctccca     2940

gtcttgtcct tacccattcc aagtgctctg ccagcccctg ttcatccaag ttttaagtcc     3000

tccaccctgt tctaagagac tgttccaacg gctctgggcc tcagtggtca cttgaccacc     3060

attgtctcag agctgcccac tttgtgtgtg tcacatgctg cctgagtcac atgtacatct     3120

tatttctgcc tctagttttg taagctcctg gagggcggat aacatcttat actactcttg     3180

tattctcatg gcacctagtg cagtgctggg cacagagtag gtgctcaata aagacttgtt     3240

gaatgaa                                                               3247


<210> 2188
<211> 2018
<212> DNA
<213> Homo sapiens

<400> 2188
ggcgggagtc gccggggctc cttcctgtgg tgcagcttcg ggtctcggag tttggcccct       60

actctgaccc caccccagct ccgctccgcc ttgggttccg gcagaacccg ccttgcggta      120

gccatggcag caggctccga ggcgaccact cctgtgatcg ttgcggctgg ggctggaggg      180

gaggaaggtg aacatgtcaa accttttaag ccagagaaag caaaagaaat tatcatgtct      240

ttacaacaac ctgcaatctt ctgtaacatg gtgtttgatt ggccagcacg acactggaat      300

gctaaatacc tttcgcaggt ccttcatggc aagcagatac gattcagaat ggggatgaaa      360

agcatgagca cagttcctca gtttgaaact acatgtaatt acgtagaagc tacactcgaa      420

gagtttctga cctggaactg tgaccagtct agtatttctg gaccatttag agattatgac      480

cattccaagt tctgggctta tgctgactat aaatattttg tcagtctatt tgaagacaag      540

acagatcttt tccaggatgt gaaatggtct gacttcgggt ttcctggaag aaatggacag      600

gaaagtacat tgtggattgg ctccttggga gcccacacac cctgtcatct ggactcctat      660

ggttgtaact tggtattcca ggtacaagga aggctggagt gcaatggcat gatcatagct      720

cctggacctc aagccatcct cctgccgcag cctctcaagt atctaggact acaggaaacg      780

atggcatctc tttcctcctg aagatactcc tttcctttat ccaactagaa tcccttatga      840

agaatctagt gtgttcagta aaatcaatgt tgtcaatcct gatttaaagc gttttcctca      900

gttccggaaa gctcaaagac atgcggttac actgagccca ggacaggttc tctttgttcc      960

cagacactgg tggcattacg tagaatccat tgatcctgtc actgtcagta taaactcatg     1020

gattgaactg gaagaggatc acctagcccg ggtagaagag gcaatcaccc gtatgcttgt     1080

gtgtgccctg aaaactgcag agaatccaca aaataccaga gcctggttaa accccactga     1140

ggttgaggaa acgtcccatg cagtcaactg ttgctactta aatgcagctg tttctgcatt     1200

ttttgatcgc tgcagaacat ctgaggtagt agaaatccaa gcactgagaa cagatggaga     1260

gcacatgaaa aaggaagaat taaatgtgtg caaccacatg gaggtgggcc aaacaggtag     1320

ccagaacttg accacaggaa cagacaaacc ggaggcagca agtccctttg gccctgatct     1380

ggtccctgta gcacagaggt ccgaagaacc gccttcagaa agaggaggca tatttggaag     1440

tgatgggaaa gactttgtgg acaaggatgg agaacacttt ggaaaattgc attgtgccaa     1500

gagacaacaa ataatgagca acagtgaaaa tgcaattgag gaacagattg cctcaaatac     1560

tactacgact cctcaaacat tcatttctac ggatgacttg ctggactgct tggtgaatcc     1620

acaagtaacc aggatagtgg cacaactttt gatacaagga agaagtttat gattcaagtg     1680

gaagatgact tttaaaataa tattttttaa atatatattt ttaagtagta tgactaaaat     1740

aaagatgaac cagcaaaagg tcagtttgca catttgtaaa tgtatttatc cttaccgaat     1800

tacatgtcag tctgttgcca ccttctttca tgcacattcc tctttggcca aactggctgc     1860

tctttgtttg taagcttttg ttcctctctc atcccatact tttagcctgt gtcaaatgta     1920

agtcccaagt atttccagca ggaagtaatg tcttcctcag cctcaaccag ggaccaaccg     1980

gctgcttact tttgcaaata aaattttact agaacacg                             2018


<210> 2189
<211> 2787
<212> DNA
<213> Homo sapiens

<400> 2189
ttgtacaggt agccaggtgt cggtctccag cctgagaact ctggctgttg ttccttgtgt       60

cgtcccatat tcctgcctgg cctgcgatgg acatcagcaa gggcctccca ggcatgcagg      120

gaggcctcca catatggatc tctgagaacc ggaagatggt gccggtaccc gagggggctt      180

acgggaactt ttttgaggaa cactgctatg tcatcctcca cgtcccccag agcccgaagg      240

ccacgcaggg ggcgtccagc gacctgcact actgggtcgg gaagcaggcg ggtgcggaag      300

cgcagggcgc tgcggaggcc ttccagcagc gcctacagga cgagctgggg ggccagaccg      360

tgctgcaccg cgaggcgcag ggccacgagt ccgactgctt ctgcagctac ttccgcccgg      420

gaatcatcta caggaaggga ggcctagcat ctgacctcaa gcatgtggag accaacttgt      480

tcaacatcca gcgactgctg cacatcaaag ggaggaagca cgtgtctgcc actgaggtgg      540

agctctcctg gaacagcttt aataagggtg acatcttcct gctggaccta ggcaagatga      600

tgattcagtg gaatgggccc aagaccagca tttctgagaa ggctcggggg ctggctttga      660

cctacagcct ccgggacagg gaacgtggtg gtggtcgtgc acagattggt gtggtggatg      720

atgaggccaa agccccggac ctcatgcaga tcatggaggc tgtgctgggc cgcagggtgg      780

gcagcctgcg tgccgccacg cccagcaagg atatcaacca gctgcagaag gccaatgttc      840

gcctgtacca tgtctatgag aagggcaaag acctggtggt cctggagttg gcgacccccc      900

cactgaccca ggacctgctg caggaggagg acttctacat cctggaccag ggtggcttca      960

agatctatgt gtggcaggga cgcatgtcta gcctccagga gagaaaggct gccttcagcc     1020

gggctgtggg cttcatccag gccaagggct acccgaccta caccaacgtg gaggtggtga     1080

acgacggcgc cgagtcggcc gcgttcaagc agctcttccg gacttggtct gagaagcggc     1140

gcaggaacca gaagctcggc gggagggata aatcgattca tgtaaagctg gacgtgggca     1200

agctgcacac ccagcctaag ttagcggccc agctcaggat ggtggacgac ggctctggga     1260

aggtggaggt gtggtgcatc caggacttac acaggcagcc cgtggacccc aagcgtcatg     1320

gacagctgtg tgcaggcaac tgctaccttg tgctctacac ataccagagg ctgggccgtg     1380

tccagtacat cctgtaccta tggcagggcc accaggccac tgcggatgag attgaggccc     1440

tgaacagcaa cgctgaggaa ctagatgtca tgtatggtgg cgtcctagta caggagcatg     1500

tgaccatggg cagcgagccc ccccacttcc tcgccatctt ccagggccag ctggtgatct     1560

tccaggagag agctgggcac catggaaagg ggcagtcagc atccaccaca aggcttttcc     1620

aagtgcaagg cactgacagc cacaacacca ggaccatgga ggtgccagcc cgtgcctcat     1680

ccctcaactc cagtgacatc ttcttgctgg tcacagccag cgtctgctac ctctggtttg     1740

ggaagggctg taatggtgat cagcgtgaga tggcacgggt ggtggtcact gtcatttcca     1800

ggaagaatga ggaaacggtg ctggagggtc aggagcctcc ccacttctgg gaggccctgg     1860

gaggccgggc cccctacccc agcaacaaga ggctccctga ggaggtcccc agcttccagc     1920

cacgactgtt tgagtgctcc agccacatgg gctgcctggt cctcgcagaa gtggggttct     1980

tcagccagga ggacctggac aagtatgaca tcatgttact ggacacctgg caggagatct     2040

tcctgtggct tggggaagct gcaagtgagt ggaaggaggc ggtggcctgg ggccaggagt     2100

acctgaagac tcacccagca gggaggagcc cggccacacc catcgtgctg gtcaagcagg     2160

gccatgagcc tcccaccttc attggatggt tcttcacttg ggacccctac aagtggacta     2220

gccacccgtc ccacaaggaa gtggtggatg gcagcccggc agcagcatca accatctctg     2280

agataacagc agaagtcaac aacttgcggc tatccagatg gccgggcaat ggcagggcag     2340

gtgccgtggc cctgcaggcc ctcaagggct cccaggacag ctcagagaat gatctggtgc     2400

gaagccccaa gtcggctggc agcagaacca gcagctccgt cagcagcacc agcgccacga     2460

tcaacggggg cctgcgccgg gaacaactga tgcaccaggc tgttgaggac ctgccagagg     2520

gcgtggaccc tgcccgcagg gagttctatc tctcagactc tgacttccaa gatatctttg     2580

ggaaatccaa ggaggaattc tacagcatgg ccacgtggag gcagcggcag gagaaaaagc     2640

agctgggctt cttctgaacc caagccctct cgactgcccc tatcccctgg accccaacat     2700

acctacaatg ctggggaggc cctgcttcca ctcccctcag aggcttttgg tcatcctctg     2760

cgtgtcagta aaagcaggca gcccata                                         2787


<210> 2190
<211> 3138
<212> DNA
<213> Homo sapiens

<400> 2190
gctctctcct cctcctcctc ctcttcctct ctggtctcct ccctcctccg ggctgggttg       60

caaatggctt cgttccccga gaccgatttc cagatctgct tgctgtgcaa ggagatgtgc      120

ggctcgccgg cgccgctctc ctccaactcg tccgcgtcgt cgtcctcctc gcagacgtcc      180

acgtcgtcgg ggggcggcgg cgggggccct ggggcggcgg cgcgccgcct acacgtcctg      240

ccctgcctgc acgccttctg ccgcccctgc ctcgaggcgc accggctgcc ggcggcgggc      300

ggcggcgcgg cgggagagcc gctcaagctg cgctgccccg tgtgcgacca gaaagtagtg      360

ctagccgagg cggcgggtat ggacgcgctg ccttcgtccg ccttcctgct tagcaacctg      420

ctcgacgcgg tggtggccac tgccgacgag ccgccgccca agaacgggcg cgccggcgct      480

ccggcgggag cgggcggcca cagcaaccac cggcaccacg ctcaccacgc gcacccgcgc      540

gcgtccgcct ccgcgccgcc actcccgcag gcgccgcagc cgcccgcgcc ttcccgctcg      600

gcacccggcg gccctgccgc ttccccgtcg gcgctgctgc tccgccgtcc tcacggctgc      660

agctcgtgcg atgagggcaa cgcagcttct tcgcgctgcc tcgactgcca ggagcacctg      720

tgcgacaact gcgtccgagc gcaccagcgc gtgcgcctca ccaaggacca ctacatcgag      780

cgcggcccgc cgggtcccgg tgccgcagca gcggcgcagc agctcgggct cgggccgccc      840

tttcccggcc cgcccttctc catcctctca gtgtttcccg agcgcctcgg cttctgccag      900

caccacgacg acgaggtgct gcacctgtac tgtgacactt gctctgtacc catctgtcgt      960

gagtgcacaa tgggccggca tgggggccac agcttcatct acctccagga ggcactgcag     1020

gactcacggg cactcaccat ccagctgctg gcagatgccc agcagggacg acaggcaatc     1080

cagctgagca tcgagcaggc ccagacggtg gcggaacagg tggagatgaa ggcgaaggtt     1140

gtgcagtcgg aggtcaaagc cgtgacggcg aggcataaga aagccctgga ggaacgcgag     1200

tgtgagctgc tgtggaaggt agaaaagatc cgccaggtga aagccaagtc tctgtacctg     1260

caggtggaga agctgcggca aaacctcaac aagcttgaga gcaccatcag tgccgtgcag     1320

caggtcctgg aggagggtag agcgctagac atcctactgg cccgagaccg gatgctggcc     1380

caggtgcagg agctgaagac cgtgcggagc ctcctgcagc cccaggaaga cgaccgagtc     1440

atgttcacac cccccgatca ggcactgtac cttgccatca agtcttttgg ctttgttagc     1500

agcggggcct ttgccccact caccaaggcc acaggcgatg gcctcaagcg tgccctccag     1560

ggtaaggtgg cctccttcac agtcattggt tatgaccacg atggtgagcc ccgcctctca     1620

ggaggcgacc tgatgtcggc tgtggtcctg ggccctgatg gcaacctgtt tggtgcagag     1680

gtgagtgatc agcagaatgg gacatacgtg gtgagttacc gaccccagct ggagggtgag     1740

cacctggtat ctgtgacact gtgcaaccag cacattgaga acagcccttt caaggtggtg     1800

gtcaagtcag gccgcagcta cgtgggcatt gggctcccgg gcctgagctt cggcagtgag     1860

ggtgacagcg atggcaagct ctgccgccct tggggtgtga gtgtagacaa ggagggctac     1920

atcattgtcg ccgaccgcag caacaaccgc atccaggtgt tcaagccctg cggcgccttc     1980

caccacaaat tcggcaccct gggctcccgg cctgggcagt tcgaccgacc agccggcgtg     2040

gcctgtgacg cctcacgcag gatcgtggtg gctgacaagg acaatcatcg catccagatc     2100

ttcacgttcg agggccagtt cctcctcaag tttggtgaga aaggaaccaa gaatgggcag     2160

ttcaactacc cttgggatgt ggcggtgaat tctgagggca agatcctggt ctcagacacg     2220

aggaaccacc ggatccagct gtttgggcct gatggtgtct tcctaaacaa gtatggcttc     2280

gagggggctc tctggaagca ctttgactcc ccacggggtg tggccttcaa ccatgagggc     2340

cacttggtgg tcactgactt caacaaccac cggctcctgg ttattcaccc cgactgccag     2400

tcggcacgct ttctgggctc ggagggcaca ggcaatgggc agttcctgcg cccacaaggg     2460

gtagctgtgg accaggaagg gcgcatcatt gtggcggatt ccaggaacca tcgggtacag     2520

atgtttgaat ccaacggcag cttcctgtgc aagtttggtg ctcaaggcag cggctttggg     2580

cagatggacc gcccttccgg catcgccatc acccccgacg gaatgatcgt tgtggtggac     2640

tttggcaaca atcgaatcct cgtcttctaa ttgcatttcc taggtttctg tgtttggggt     2700

gtgtgtgcgt gtctctctct ctctctctct ctttctcttt ctctctcttt ttgaatttca     2760

aagaagaaac agtctcaggg aaatttcttt tttctttttt ttttttaaag agaacaagaa     2820

aagtacaaca ttgcttaagt cctacctcat ctttattttt ttacagatga atgtacttat     2880

cttttctgca gggattgagc ctgtgaagtg ataatttcta tctacctcat aaatctttac     2940

atttccttct gcaacaggcc ctcttcccct cctcagtgga gtttgcattt ccctcttccc     3000

ctgcgtgggg catgatatgc acaagcctgg catctgtatg gctgggaggg cactggatgt     3060

gtgtggtggg gtgtattctg tagattgagc caaggaaaca caaaaaaaaa ctactaagta     3120

aaaaaacaaa aaactata                                                   3138


<210> 2191
<211> 1479
<212> DNA
<213> Homo sapiens

<400> 2191
gtccgagacc tggagcagcc accgccgcaa tcatgacttc ggggacctgg tttttagaga       60

gtctagaatc tgatgagaga acctgtgctt acttggtgtg tacctcttga actgctttgc      120

agccatcctc ttccactgtc tgcctttctg aaatcacaag tcaaacttta tacctacagg      180

gcttgtgctg gaaaagatga aatggggaaa atggtgtcag taattaacac tgtggatacc      240

tcccatgagg acatgattca cgacgcccag atggactact atggcacccg cctggcaacc      300

tgctcatcag acaggtccgt caaaatcttt gatgtgcgca atggagggca gatccttatc      360

gccgacctca ggggtcatga gggtcctgtg tggcaagtgg cctgggctca ccccatgtac      420

ggcaacatcc tggcatcgtg ctcctatgac cggaaagtca ttatctggag agaggaaaac      480

ggcacctggg agaagagcca cgagcatgcg ggacacgact cctcagtgaa ctcggtgtgc      540

tgggcccccc atgactacgg cctgatcctg gcctgtggga gctcggatgg ggccatctcc      600

ctgctgactt acaccgggga aggccaatgg gaagtaaaga agatcaacaa cgctcacacc      660

attggctgca atgccgtcag ctgggcccct gctgttgtac ctggaagcct catagaccac      720

ccatcggggc agaaacccaa ttacatcaag aggtttgcat caggtggctg tgacaacctc      780

atcaagctgt ggaaggagga ggaggacggc cagtggaagg aggagcagaa gctagaagcg      840

cacagtgact gggttcgaga tgtggcctgg gccccctcca tcggcctgcc caccagcacc      900

atcgccagct gctcccagga tggtcgtgtg ttcatttgga cctgtgatga tgcctcaagc      960

aatacgtggt cccctaaatt gttgcacaag ttcaacgatg tggtgtggca tgtgagctgg     1020

tccatcacag ccaacatcct ggctgtctct ggtggagaca ataaggtgac cctgtggaag     1080

gagtcagttg atgggcagtg ggtgtgcatc agtgatgtca acaagggcca gggctccgta     1140

tcagcatcag tgacagaggg ccagcagaac gagcagtgac aagacaggtg gggcctggct     1200

ccccacccgc cagctccagg actgcccctt cctgggccaa ctaaccagac aactgggaag     1260

agcccccaac tccaacagga ttattttccc aggaggagtt acagatgcag ccacagattg     1320

atcatctgcc ttaacgtgat cggagatgct ttgtaatcta ctgtccagct gaaagcactc     1380

atgttacgag gaagaaacta caagtgatgt tcaaatctat tttgggtcat ttttatgtac     1440

ctttgggttc aggcattatt tggggggttt tgtttccaa                            1479


<210> 2192
<211> 4834
<212> DNA
<213> Homo sapiens

<400> 2192
ttcttttttt tttttgagac ggagtctcgc tctgtcaccc aggctggggt gcagtggcgc       60

gatcttggct cactgcaagc tccgcctccc aggttcccgc cattctcctg cctcagcctc      120

ccgagtagct gggactacag gcgcccgcca tcacgcctgg ctaatttttt gtatttttag      180

tagagacggg gtttcactgt gttagccagg atggtctcga tctcctgacc tcatgatcca      240

tccacctcag cctcccaaag tgctgggatt acaggcgtca gccaccgtga ccagcctgaa      300

acaggagcaa gttctaaact caggctctag agtcagaaaa ggtagagtca ggttctggat      360

ccaaaatggg gcaagtcatg atcaggttct ggaaccagaa caggcctcaa gcctaggggc      420

tgagcagggt atcccctggc ctgggagcag aggacttctg gctgactgct gcccgcaacg      480

ttctcaagct ggtggtgaag tctgagtgga agtcataccc tattcaggca gtagaggaag      540

aggcctcagg taagtactgt ggttacctcc actctcccac ccatttatcc tccacccatc      600

cgcccttcca cctatctgcc cttctaccta tctattcatc cacgcaccta ctggttcatc      660

cacacatctg tgtatgattc acatctaccc atctatccat ccatccacca gccatccatc      720

cactcatcca cccacgtatt cacccactct ctgatctacc gattcaccca cccacccttc      780

cactcatcct tccatcctcc cacctgtcac ccattgttaa tctcgtcatt catctacctg      840

atgtcagctc catactcccc atccatctat ccactccctg cctacctatc cttccacaga      900

tccacctacc catctatcta cctgctattc cattctccca tctactacct atctgttctt      960

caggccatcc actcatccat tcttctgtcc caggtactta gacacttgtc ttcccatccg     1020

tttgttagtt gatccactcc tcattcagcc ctcccatggg cctggcatgt agccgagcac     1080

cctggagagg gcagactaag aagacatggt ccgtccctgc ctgtgaggag ttcaggtctc     1140

tgaggaggag gaagcagtga aactgggctt tacacatggc ctgagaacag cttaggcctg     1200

aacataagga acagcttgga gtggagggga cacagaggaa ccctcactat catgcatgcc     1260

aacccaacca ctgcctgccc tttcccttct ggatttagct cgtgtctcca ggctcctagt     1320

cctgtaatcc agggacccat cagcgaggga ttcagggaag cagaggcagc tctccaggaa     1380

ggaggaaaat ccctgcctct tccagagaga ctcccccatt gctgtctctt gtgtgtgtca     1440

tgcacaagga aggcttggtt gtgtgccagg ataaggggca caagggcctc gggtgtggcc     1500

agagacccca tgcttaagct tttatggtat aggtcaggct gcaggggttt gagggcctca     1560

gttgtatatc agaatcttca gagcactgcg atgttcaggg gtgagtcagg tctgtagatg     1620

tgcacggggt cttctgaagg gtcagtttct gtaatcactt tcaggtgtgt cagggccttg     1680

tgcagtaaca gtgcacacag aagttagtgt ttctgtgggc taagggttgt agctctgtat     1740

caggattctg ggagtgggtc tggatttctg gtgtgtggac ttaagaagct gtgtcagact     1800

tgggggaggg gcgttcatgt ataactgggt tcacataggc caagactccc aggtgcattt     1860

taggcagagc ctcaggtgtg ttagaggtcc caggggcaga gaggctatag gtgctgtcag     1920

aggccttggg gacatttagg gcagagcctc gagtgacagg tcctgggaca gtgggagcca     1980

agggcaagtg ctagagttgc agtgaattta gagcaaagcc tcagctaagt gacacatccc     2040

agggcagtag gggatctatc taggttcgtg ctgggcctca ggtaagtgac aggccttagg     2100

acaatggggg ctgtggcatg cgtcaggtta cctgccttga tatgggatcg tgacaggccc     2160

ctccctatgt gcaggagaca agcagcccaa gaaacaggag aaaaacccag tgttggtgtc     2220

cccagagttt gtggatgaag ctctgtgtgc gtgcgaggag taccttagca acttggccca     2280

catggacatc gacaaggacc tggaggcccc gctgtacctc acccccgagg gctggtccct     2340

cttcctccag cgctactacc aagtggtcca cgaaggggca gaactcaggc acctcgacac     2400

tcaggtccag cgctgtgagg acatcctgca gcagctgcag gccgtggtac cccagataga     2460

catggaaggg gatcgcaaca tctggatcgt gaagccagga gccaagtccc gcggacgagg     2520

catcatgtgc atggaccacc tggaggagat gctgaagctg gtgaacggca accccgtggt     2580

gatgaaggac ggcaagtggg tggtgcagaa gtatattgag cggcccctcc tcatctttgg     2640

caccaagttt gacctcagac agtggttcct ggtaactgac tggaacccac ttaccgtgtg     2700

gttctaccgc gacagctata tccgcttttc cacgcagccc ttctccctga agaacctgga     2760

caactcagtg cacctgtgca acaactccat ccagaagcac ctggagaact catgccatcg     2820

gcatccactg cttccgccag acaacatgtg gtctagccag aggttccagg cccacctgca     2880

ggagatgggt gccccaaatg cttggtccac catcatcgtg cctggcatga aggatgctgt     2940

gatccacgca cttcagacct cccaggacac cgtgcagtgt cggaaggcca gctttgagct     3000

ctatggcgct gacttcgtgt tcggggagga cttccagccc tggctgattg agatcaacgc     3060

cagccccacg atggcaccct ccacagcagt cactgcccgg ctctgtgctg gcgtgcaagc     3120

tgacaccctg cgcgtggtca ttgaccggat gctggaccgc aactgtgaca caggagcctt     3180

tgagctcatc tataagcagc ccgtcaccac ttccccagcc tccacaccaa ggcccagctg     3240

ccttctcccc atgtactccg acaccagggc caggtcctca gacgacagca cagcaagctg     3300

gtgggcacta aggccctgtc gaccacaggc aaggccttga ggactctacc cacggctaag     3360

gtcttcattt ccctcccacc gaaccttgat ttcaaggtgg cacccagcat cctgaagcca     3420

agaaaggtgg gcctcgacct gtgactcaca cccagtggac agtgctgagc acggggtcag     3480

ggctggaggg cacaggcaga gggcagctcc caggctggct ggcaccccaa gggaagagct     3540

ggtctccctc agaagcccct tcctccacag acttctgatc atctccctct tctcccctcc     3600

tttcacaccg aggctcctgc tctcctgtgc ctccgaggcc cccagctgga agtgccttgt     3660

tgcctctgcc ctttgaagtc ggaacaattc ctagcacctg tcggaaggtc aaggccaaag     3720

gcaaattcaa ggccagactg tgacaaaccc agggctgagg cctgccccat gaagaggctg     3780

agccccctga aacccctgcc ccttgttggt acattccaga ggcgcagggg cctgggggat     3840

atgaagctag ggaagcccct gcttcgattc cccactgccc ttgtcctgga tccaacacca     3900

aataaaaaga aacaagtgaa gtatttgggg cttgactcca ttgctgttgg agggtcaaga     3960

gtggatgggg cgaggccgtg taccccaggg tccacagcaa gagcctgagg ccatcagcag     4020

ctcctccgtg cagcgaggcc cagaattccc acctaaggac agacatgggg cttcctattt     4080

agggactccc ccagcatctc cgatccaggg gtggggagcg tgagccttca ctttacagat     4140

gaagaaactg agtctgaaag aggaggcatg gcttacccaa gatcacgtgg cagtgagtcg     4200

acgcagggac atattgccag aactgccgag cactgggagc cccccaaccc cagagaacaa     4260

gccaagctag cagaatgaca cctaccgggc ataggaacgt taatgccatg agacagggga     4320

aggaattggc cttgcctaaa cctcagccct tctgcagagg gcatgggtct atcccttctt     4380

cagcaagggg ccaaggtcac ctaaaaatga aacatccaat aagccacacc cacctgaaga     4440

aaagtgtggc actgcttagt tgtagtgggt tgaactgtgg tcccctgaaa agagatgtct     4500

acttggaccc tgtgaatgtg accttatgtg ggaaaagagt ctttgtagct gggtatggtg     4560

gctcacacct gttatcccag cactttgaga ggccaaggca ggagatcgct tgagcccgca     4620

agttcaagac cagtctgggc aacatggtga aaccgtttct acagaaaatt agctgggtgt     4680

ggtggcacac acctgtagtc ctagctactc gggaggccta ggtgggagga ttacctgagc     4740

ctgggaagat caaaactgtg gtgagctgtg atcacgccac tgcgctctga gcctgggaga     4800

cagagtgaaa ccctaaatca aaaaaaaaaa aaaa                                 4834


<210> 2193
<211> 2335
<212> DNA
<213> Homo sapiens

<400> 2193
caagattcga gcctgagcgg cctgggcgtc tcgagaggtg agagagttgg cggcgaggtc       60

tcggcggcta agcgagcgtc ggcgactgtc tctccgcgag aggaggcaag ttggggtcca      120

ggctccaaag ccggtggccg cgtaccgcgg tggagccgct gtctttgagg tctgaggaga      180

gaacagagtc tagctctttc acccaggctg gagtgaagtg gtgcaatctc agctcagtgc      240

aacctccgcc ccctgggttc aagtgattct cctgcctcag cctccccagt agctgggatt      300

acagtgatat cctgagagaa gatgggaaag ggctgcaagg ttgtggtttg tggattgtta      360

tctgtgggga aaactgcaat tttggagcag ctcctttatg gaaatcatac tattggaatg      420

gaagattgcg aaacaatgga agatgtatac atggcttcag tagaaacaga ccgaggagta      480

aaagaacagt tacatcttta tgacaccaga ggtctacagg aaggcgtgga gctgccaaag      540

cattattttt catttgctga tggcttcgtt cttgtgtaca gtgtgaataa ccttgaatcc      600

tttcaaagag tggagcttct gaagaaagaa atcgataagt tcaaagacaa aaaagaggta      660

gcaattgtgg tattaggaaa caaaatcgac ctttctgagc agagacaagt ggacgctgaa      720

gtggcacagc agtgggcaaa aagtgagaaa gtaagactgt gggaggtgac tgttacagat      780

cggaaaactc tgattgaacc attcacttta ttagccagta aactttctca accccagagc      840

aaatcaagct ttcctttgcc tgggaggaaa aacaaaggga actctaattc tgagaactaa      900

aaatcagtaa tttccacaat tgtatgttga atagtgattg cctttaagtg tctgtgaaca      960

tggagtaata ttactattta aaataggcca tttgtatcta cctttggtcc ttaggaaaat     1020

tcctaaggaa gtcaattaat gcactttaga tgttaaaagt atttgggcta aggttattat     1080

tgcctgatat gaaataatat attcttattc tcattgtttg aaacctgtct ttgaaattag     1140

cacctttgtt atttatgttg tacttgtgaa aacagtaaaa tagtttggat agttatgcaa     1200

atgcacctat gtgtaacttc cccccaaccc caagctgttt cggaagatat cataatcatt     1260

ctgtgtaaca ttatgcaaac ttctaagccc aaacatgact ttgtttttaa aaagttcatt     1320

aatctaatgt ctaggattat aaaacatttt tttgtgtcta aattggaccc aaaacattga     1380

acagtttggg gtagtaagct aaatttcatc ttgtggagat tttgctaaac agactaagac     1440

ccatgattta gctttgctca aattagaatg tttagcatga gttgaggtac caggtagtgt     1500

taagtaggtt catcacgctc taaggccgtt ttttccttag ccagacccct gttgatagac     1560

cagatacttg agggcaaact gtttgctcct cctcttgaaa atgattaggc acttaaggac     1620

agtaaagctg tattttctgg aaggaagact gtatcttctg gaatagtttt ctagaaaact     1680

agtcatatac aataaaagta tcaaaaatat tgggctctaa tttgatctga cttagatgtc     1740

tgagtttgtg ttgtttctct aaagattttg gcaagactca agcaatgtgg ctgactgtaa     1800

ctttattaat ttaaaaggta ggaagtaagc tacttagtgg tttcacctgt gaaataacta     1860

ttttgactga aatgtaaaat aagctattca acaaagaaca tattaaaaca tcaagtaatt     1920

tgtaacatct taaatggaat acttttttca tgagctctag tgaagaacta ctacatataa     1980

aagacgatac ttacaaatca gctattgctg ctacagtata attcttcaaa atttctcatc     2040

ataaattcat tttttggtaa aaaaaaatta ccagacacta actcaccccc ttaccctttt     2100

cccccggtta ttgaatatta atctagcttc ccacccatgc atgttacata gatggacaaa     2160

tgctttcata atgattttta aataagtacc ttccagtttg ctttgtttcc tactaatgca     2220

acttagtcta tattagtaca aacagttacc aattcttttt aaattctgta atgaatgtat     2280

gtgtatccag ataagtttct ctgaaagaga catacagaaa cagaactgct gggtc          2335


<210> 2194
<211> 2397
<212> DNA
<213> Homo sapiens

<400> 2194
ctatgagcag acgtgtggtt cggcaaagca agttccgcca tgtgtttggg caggcagcaa       60

aggccgacca ggcctacgag gacatccgtg tgtccaaggt cacatgggac agctccttct      120

gtgccgtcaa ccccaaattc ctggccatta ttgtggaggc tggaggcggg ggtgccttca      180

tcgtcctgcc tctggccaag acagggcgag tggataagaa ctacccactg gtcactgggc      240

acactgcccc tgtgctggat attgactggt gtccacacaa tgacaacgtt atcgccagtg      300

cctcagacga caccaccatc atggtgtggc agattccaga ctataccccc atgcgcaaca      360

ttacggaacc tatcatcaca cttgagggcc actccaagcg tgtgggcatc ctctcctggc      420

accctactgc caggaatgtc ctgctcagtg caggtggtga caatgtgatc atcatctgga      480

atgtgggcac cggggaggtg ctgctgagcc tggatgatat gcacccagac gtcatccaca      540

gtgtgtgctg gaacagcaac ggtagcctgc tagccaccac ctgcaaggac aagaccttgc      600

gcatcattga ccccagaaaa ggccaagtgg tggcggagag gtttgcggcc cacgagggga      660

tgaggcccat gcgggccgtc ttcacgcgcc agggccatat cttcaccacg ggcttcaccc      720

gcatgagcca gcgagagctg ggcctgtggg acccgaacaa cttcgaggag ccagtggcac      780

tgcaggagat ggacacaagc aacggggtcc tattgccctt ttacgatccc gactccagca      840

tcgtctacct gtgtggcaag ggcgacagca gcattcggta ctttgagatt accgacgagc      900

cgcctttcgt gcactacctg aacacgttca gcagcaaaga gccgcagcgg ggcatgggtt      960

tcatgcccaa aaggggactg gatgtcagca agtgtgagat cgcccggttc tacaagctac     1020

acgaaagaaa gtgtgaacct atcatcatga ctgtgccccg caagtcagac ctcttccagg     1080

acgatctgta cccggatacg ccaggcccgg agccggccct agaagcggac gaatggctat     1140

ccggccagga cgccgaaccc gtgctcattt cgctgaggga cggctatgtg ccccccaagc     1200

accgcgagct ccgggtcacg aagcgcaaca tcctggacgt gcgcccgccc tccggccccc     1260

gccgcagcca gtcggccagc gacgccccct tgtcgcagca gcacaccctg gagacgctgc     1320

tggaagagat caaggccctc cgcgagcggg tgcaggccca ggagcagcgc atcacggctc     1380

tggagaacat gctgtgcgag ctggtggacg gcacggacta gccccgcgcg ccaggcaggc     1440

ggagcggggc ggggcgcaca agctcggccc cgccccggct tttagtcccg aactccggac     1500

cccgccttct tgggctgggc ccgggggcgg gactggggag ggaactccgc ccctcgcggg     1560

agaccagaac tcttggagct taggggagac ccacgtcgct ccagcggagg ctggactgcg     1620

agcctcgtct gggactcggc tggagctggc ctagggaggc ctggggtaac ctggggggct     1680

cagcaatggt gctgcacggc gaggtggtgt ccccctttgt cctccgccca gggcagggaa     1740

agtgcttagt attagcgtga tgcttggggt tattggagcc tgagcttgac ctcaaacggg     1800

tggcgatttg atgggtaccc ccaggctggg gaaaatgaca gcgcttctcc taatcagctc     1860

actggattcc atcaccctga gcggtaaacc agatgggcgt caccccagtt ctgcagacac     1920

atacacaacc cgtttgctgc agagccggac ccagtggcta cacccacagc ggtctgtggt     1980

agagaactct cttccttctt tccaccgaca ggggcgaggg ctgcttcctc gcggcagccc     2040

ccgcgaagaa atctcgagag aactggcatg aggagttagg ttcatcacaa atacacacac     2100

actgccccca accctctgcc gttgcctctc tcagaaaaac aagacgtact gaatgaaata     2160

ttttactaag cgttcagtct gtgcctcctg catgggtggg agtgagggga acgagacccc     2220

cagcctctgc aaatgctacc cccaggctcc tgggagacct ggcgatgcac tcctgggctc     2280

agggtccatc aggcagcctc ttaccctaga gctctctcca ctctgaggtt cagaaggacc     2340

ccaacccaca ccgtaggcgt tccccccaag taaagttagg tagcaaaagc ctccggt        2397


<210> 2195
<211> 2963
<212> DNA
<213> Homo sapiens

<400> 2195
gggtgacgca ggcgcagcgc gggctgcgcg cgctactgcc catccccggt tgtcccactt       60

ttgttcgcct ctcttcggcc ctctactcaa gagctccgtc tccgtctcgc cctcctcgaa      120

gtcctcgtcg cgcgcccgcg acccaggtcg ccctgaaatc tagcccgtcc gagcgcgagt      180

ccaacgccgc ggccgcacca aggccccctc agaccgtgcc atgggtgaca gtgatgacga      240

gtacgatcga aggcgcaggg acaagttcag aagagagcgc agcgactacg accgttcccg      300

cgagagagat gaaagacgtc gaggggacga ttggaatgac agagagtggg accgtggccg      360

tgagcgccgt agtcggggtg aatatcggga ctatgaccgg aatcggcgag agcgcttctc      420

gccacctcgc cacgaactca gcccgccaca gaagcgcatg aggagagact gggatgagca      480

cagctctgac ccataccaca gtggctatga gatgccctat gctggggggg gtgggggccc      540

aacttatggc ccccctcagc cctggggcca ccctgacgtc cacatcatgc agcaccatgt      600

cctgcctatc caggccaggc tgggcagcat tgcagagatt gacctgggtg tgccgccgcc      660

cgtgatgaag accttcaagg agtttctcct ctccctggat gactcggtgg atgagacgga      720

ggccgtcaag cgctataatg actacaagct ggatttccgg aggcaacaga tgcaggattt      780

cttcctggcg cacaaagatg aggagtggtt tcggtctaag taccacccag atgaggtggg      840

gaagcgtcgg caggaggccc ggggggccct gcaaaaccga ctgagggtct tcctgtccct      900

catggagact ggctggtttg ataaccttct cctggacata gacaaagctg atgccattgt      960

caagatgctg gatgcagccg tgattaagat ggaaggaggc acggagaatg atcttcgcat     1020

cctggagcag gaggaggagg aggagcaggc aggaaagcct ggggagccca gcaagaaaga     1080

agaaggacgg gctggagcag gcctagggga cggggagcgc aaaaccaacg acaaggatga     1140

gaagaaggaa gacggcaagc aggctgagaa tgacagttct aatgatgaca aaacaaagaa     1200

gtcggagggt gatggggaca aggaagagaa gaaagaagac tccgagaagg aagccaaaaa     1260

gagtagcaag aagcggaacc ggaagcacag tggtgacgac agctttgacg agggcagcgt     1320

gtcagagtct gagtcggagt cagagagcgg ccaggctgag gaggagaagg aggaggccga     1380

agcgctcaag gagaaggaga agcccaagga agaagaatgg gagaagccca aggacgccgc     1440

ggggctggag tgcaagccgc ggccgctgca taagacctgc tccctcttca tgcgcaacat     1500

cgcgcccaac atctcccggg ccgagatcat ctccctttgt aaaaggtacc caggctttat     1560

gcgggtggcg ctctcagagc cccagccaga gaggaggttt ttccgtcgtg gctgggtgac     1620

cttcgaccgc agtgttaaca ttaaagagat ctgttggaac ctgcagaaca tccgtctccg     1680

ggagtgtgag ctgagccctg gtgtgaacag ggacctgacc cggcgcgttc gcaacatcaa     1740

cggcatcacc cagcacaagc agattgtgcg caacgacatc aagctggcgg ccaagctgat     1800

ccacacgctg gatgacagga cacagctttg ggcctcagaa ccagggacgc ctcccctgcc     1860

cacgagcctg ccctcgcaaa acccgatctt gaagaatatc accgactacc tgatcgagga     1920

agtaagcgcc gaggaggagg agctgctggg gagcagcggg ggcgctcctc ctgaggagcc     1980

tcctaaggaa gggaacccgg cagagatcaa cgtggagcgg gatgagaagt tgattaaggt     2040

cttggacaag ctcctccttt acctgcgcat cgtgcattcc ttggattatt acaacacctg     2100

tgagtacccc aacgaggacg agatgcccaa tcgctgtggg atcatccacg ttcgggggcc     2160

catgccaccc aaccgcatca gtcacgggga agtgctggag tggcagaaga cttttgagga     2220

gaagctcacg ccgttgctga gtgtgcggga gtcactctca gaggaagagg cccagaagat     2280

ggggcgcaaa gacccagagc aggaagtgga gaagttcgtc acctccaaca cgcaggaact     2340

gggcaaggat aagtggctgt gtcctctcag tggcaagaaa ttcaagggtc ctgagtttgt     2400

gcgcaaacat atcttcaaca agcatgcaga gaaaattgag gaagtgaaaa aggaagtcgc     2460

gttttttaac aacttcctca ctgatgctaa gcgcccagct ctgcctgaga tcaagccagc     2520

ccagccacct ggccccgccc agatactccc cccaggtttg accccaggac tcccctaccc     2580

acaccagact ccccagggcc tgatgcccta tggtcagccc cggcccccga tcttgggcta     2640

tggagctggt gctgtccgcc ctgcagtccc cacaggaggc cctccatacc cccatgcccc     2700

gtatggtgct ggtcgaggga actatgatgc cttccgaggc cagggaggtt atcctgggaa     2760

acctcgcaac aggatggttc gtggagaccc aagggccatt gtggaatatc gggacctgga     2820

tgccccagac gatgttgatt tcttttgagc cgtcccccgt tcctcagtcc tgtatcatcc     2880

atacttgtac taccttgtcc tatgaagctc tgagaatttt ttgtacgatc agccttactg     2940

ctaataaaag cacttccaca ggg                                             2963


<210> 2196
<211> 826
<212> DNA
<213> Homo sapiens

<400> 2196
ctcagcgaag atggcggcag tggagaagcg gcggcaagcg gtaccaccgc cggccggttt       60

cacggacagc ggccgccagt cggtatcccg ggcggcgggg gcggccgaga gcgaggagga      120

cttcctgcgg caggtcggcg tgacggaaat gctacgtgcg gccctgctga aggtgctgga      180

ggcgcggccc gaggagccga tcgccttcct ggctcactac ttcgagaaca tgggcctgcg      240

ctcgcctgta aacggcggcg ccggggagcc cccgggccag ctcctgctgc agcagcagcg      300

cctgggccgc gcgctatggc accttcgcct ggcccaccac tcccagaggg ccgccttcaa      360

caacaacgtg agcgtggcct acgagtgcct gagcgccggc gggcgcagga agaggccggg      420

gctggacggg cgcacctaca gcgagctgct caggcgcatc tgccgggacg gccaagcccc      480

cgaggaggtg gtggcgccgc tgctgcgcaa ggtgcagtgc cgtgaccacg aggcggtgcc      540

gctgagcgtc ttccgcgcgg gcacactcac ctgcttcgtg ctgctggagt tcgtggcgcg      600

cgccggcgcg ctcttccagc tgctggagga ctcggccgcc gccgtggccg accgccgcgt      660

gggccaggcc gtgctggaca ccctggaggg cgcgctgcag gccagcgacg ccgccgcgcc      720

cgcgcgcttc ctggaggccg gctcgcgctt ggcgcccatg acccgcgagg agtttctgga      780

gagggccgcc gcgctcttca tcgcgaaggt caagccggtg ggctga                     826


<210> 2197
<211> 2429
<212> DNA
<213> Homo sapiens

<400> 2197
gctgattgcc cgcctgcccg tgggtcatgg cctgccagca gtcgcggtac cacagcttct       60

cgtccgcgtc gaggtaggcg ctggcaggga tgagggcaga gatgagggtt tgagtacttc      120

tagagaggga aatggcactt gatccggacc tctgcacctc ctgctggcct ctgaccattg      180

atctagggct ccagcaccac agagtcaatg gttagaatcg ggctgattta gcccagtgaa      240

gacgttacgt gctagcaaaa cgattacagc cacggccttc aggagtgacc atagacgaat      300

cctttctcac agaagacaag agcacccaga atcgcaagct tcttcagaaa cgaaggacgc      360

tgactggtca gttctccatg ggtgggcacc tgtccccatg gcccacatac accagtggcc      420

agaccatttt gcaaaatcga aaaccctgtt cagatgacta ccggaagcga gtagggagct      480

gccagcagca cccctttcgc actgccaagc cccagtactt ggaggaactg gaaaactacc      540

tacgcaagga gctcctcctg ctggacctgg gcacagattc cacccaggaa ctaaggctgc      600

agccttacag agagatcttt gagttcttca tagaggactt caaaacgtac aagccattac      660

tatcctccat caagaatgcg tatgagggga tgctggccca ccaaagggag aagattcggg      720

ctctggagcc cctgaaggcc aagcttgtca ctgtgaatga ggactgcaat gagaggatcc      780

tggccatgag agctgaggag aaatatgaaa tctccctgct caagaaagag aagatgaact      840

tgctaaaact catcgacaaa aagaatgagg agaagatttc attgcagagc gaggtgacca      900

aactgaggaa gaacttggct gaggagtacc tgcactacct cagtgagcga gatgcctgta      960

agatcctcat cgcagacctg aatgagctgc ggtaccagcg ggaggacatg tcattagccc     1020

agtcgccagg catctggggg gaggaccctg tgaagttaac cctggctctt aagatgaccc     1080

ggcaagacct gacccgcacg cagatggaac tcaacaacat gaaggccaac tttggagatg     1140

tggtccccag gagggacttt gaaatgcagg agaagaccaa caaggatctt caggagcagc     1200

tggacaccct gagagccagc tacgaggagg ttcgcaagga gcatgagatc ctcatgcagc     1260

tgcacatgag cacgctgaag gaacgggacc aattcttctc tgagctgcag gagatccagc     1320

gcacttccac gccgcggcct gactggacca agtgcaaaga tgtggtggct gggggcccag     1380

agcgctggca gatgctggct gagggcaaga acagcgacca gctggtggac gtgctcctgg     1440

aagagattgg ttcggggctg ctgcgggaga aagacttctt ccctggtctg ggctatgggg     1500

aagccatccc tgcttttctt cggtttgatg gcctcgtgga gaacaagaag ccaagcaaga     1560

aggacgtggt caacctcctc aaggatgcct ggaaggaacg tcttgctgag gagcagaaag     1620

agacgttccc agatttcttc ttcaatttcc tggagcatcg ctttgggccc agtgatgcca     1680

tggcctgggc ttatactatt tttgaaaata tcaagatctt ccactccaac gaggttatga     1740

gtcagttcta tgcagtcttg atgggaaagc ggagtgagaa tgtgtatgtc acccagaagg     1800

agacagtagc ccagctgctg aaggagatga caaatgctga cagtcagaac gaggggctac     1860

taaccatgga gcagttcaac actgtcctca agagtacctt ccctctcaag acagaagagc     1920

aaatccagga gctgatggag gcagggggct ggcatcccag cagcagcaat gcagacttgc     1980

tcaactaccg ctcactgttt atggaggatg aggagggcca gagtgagccc tttgtgcaaa     2040

aactctggga acaatacatg gatgagaagg acgagtactt acagcagcta aagcaggagc     2100

ttggcataga actccatgag gaagtgactc tgcccaagct gcgagggggc ctgatgacca     2160

tcgaccccag cctggacaag cagacagtga acacctacat gagccaggcc ttccagctcc     2220

ctgagtcgga aatgccagag gagggtgacg agaaggaaga agccgtggtg gaaatcctcc     2280

agactgccct ggagcggctt caggtgattg acatcaggcg tgtgggacct cgagagccag     2340

agcctgcaag ctaggaactt gtgggcagcc tgcgtactcc agtcctgcta acccctagct     2400

tttaatataa aagtgtttgt ctgaatcca                                       2429


<210> 2198
<211> 1287
<212> DNA
<213> Homo sapiens

<400> 2198
atggagccgc tgaaggtgga aaagttcgca accgccaaga ggggaaacgg gctgcgcgcc       60

gtgaccccgc tgcgccccgg agagctactc ttccgctcgg atcccttggc gtacacggtg      120

tgcaagggga gtcgtggcgt cgtctgcgac cgctgccttc tcgggaagga aaagctgatg      180

cgatgctctc agtgccgcgt cgccaaatac tgtagtgcta agtgtcagaa aaaagcttgg      240

ccagaccaca agcgggaatg caaatgcctt aaaagctgca aacccagata tcctccagac      300

tccgttcgac ttcttggcag agttgtcttc aaacttatgg atggagcacc ttcagaatca      360

gagaagcttt actcatttta tgatctggag tcaaatatta acaaactgac tgaagataag      420

aaagagggcc tcaggcaact cgtaatgaca tttcaacatt tcatgagaga agaaatacag      480

gatgcctctc agctgccacc tgcctttgac ctttttgaag cctttgcaaa agtgatctgc      540

aactctttca ccatctgtaa tgcggagatg caggaagttg gtgttggcct atatcccagt      600

atctctttgc tcaatcacag ctgtgacccc aactgttcga ttgtgttcaa tgggccccac      660

ctcttactgc gagcagtccg agacatcgag gtgggagagg agctcaccat ctgctacctg      720

gatatgctga tgaccagtga ggagcgccgg aagcagctga gggaccagta ctgctttgaa      780

tgtgactgtt tccgttgcca aacccaggac aaggatgctg atatgctaac tggtgatgag      840

caagtatgga aggaagttca agaatccctg aaaaaaattg aagaactgaa ggcacactgg      900

aagtgggagc aggttctggc catgtgccag gcaatcataa gcagcaattc tgaacggctt      960

cccgatatca acatctacca gctgaaggtg ctcgactgcg ccatggatgc ctgcatcaac     1020

ctcggcctgt tggaggaagc cttgttctat ggtactcgga ccatggagcc atacaggatt     1080

tttttcccag gaagccatcc cgtcagaggg gttcaagtga tgaaagttgg caaactgcag     1140

ctacatcaag gcatgtttcc ccaagcaatg aagaatctga gactggcttt tgatattatg     1200

agagtgacac atggcagaga acacagcctg attgaagatt tgattctact tttagaagaa     1260

tgcgacgcca acatcagagc atcctaa                                         1287


<210> 2199
<211> 1235
<212> DNA
<213> Homo sapiens

<400> 2199
gcgggcgctg cggcccctgc tctacctcct agcgccggtg cgcggccgag gccgcactac       60

ctgtctgcgg gaaagcggga tccaccccag gacgtcgggt cgctgccgac ataatgtcaa      120

gtggaaacta tcagcagtca gaggctctta gcaaacccac tttcagtgag gaacaagcct      180

ctgcgttagt ggagtcagtg tttgggttga aagtttccaa ggtccggcca cttcctagct      240

atgatgacca aaactttcat gtctacgttt caaaaaccaa agatggccca actgaatatg      300

tcctcaaaat aagcaacacc aaggctagca aaaatccaga cctgattgaa gtgcagaatc      360

acatcatcat gtttctgaaa gccgctggat ttccaacagc ctctgtgtgt cacactaaag      420

gagacaacac agcttctctc gtgtctgtag atagtggctc tgaaatcaaa agctacttgg      480

tgaggctgct gacttacctc ccaggaagac ccatcgctga gcttcccgtc agcccccagc      540

tattgtatga aattggaaaa ctagctgcca aattggataa gacactgcag agattccatc      600

acccaaagtt aagtagtctt catcgggaga acttcatctg gaatctgaaa aatgttcctc      660

ttctggagaa atacctgtat gccctgggcc agaatcgaaa ccgagagatt gttgagcatg      720

tcattcatct gttcaaggag gaagtaatga ccaaattaag tcattttcga gaatgtatca      780

atcacggaga tcttaatgac cataatattt taatagagtc cagcaagtca gcctctggaa      840

atgctgaata tcaagtgtct gggattttag actttggtga catgagctat ggctactatg      900

tgtttgaagt ggcaattacc atcatgtaca tgatgattga gagcaagagt cctatacaag      960

taggaggcca tgtccttgca gggtttgaaa gcatcacccc actgacagct gtagagaagg     1020

gtgctttgtt tttacttgta tgcagtcgtt tttgtcagtc acttgtcatg gctgcatact     1080

cttgccagct atacccagag aacaaagact atctcatggt tactgcaaaa accgggtgga     1140

aacacttaca gcaaatgttt gacatgggtc agaaagctgt agaagaaatc tggtttgaaa     1200

ctgccaaatc ctatgaatct gggatctcca tgtga                                1235


<210> 2200
<211> 2766
<212> DNA
<213> Homo sapiens

<400> 2200
atggctttgc tgtgtggcct tgggcaagtc actctgcgta tctgggtttc acttccttcc       60

caatccgaaa acgggattgg gagcggcggc atggaggctc tcaccactca gctggggccg      120

gggcgcgagg gcagttcctc gcccaactcc aagcaggagc tgcagccgta ctcgggctcc      180

agcgctctca aacccaacca ggtgggcgag acgtcgctgt acggggtgcc cattgtgtcg      240

ctggtcatcg acggccagga gcgcctatgc ctggcgcaga tctccaacac cctcctcaag      300

aactacagct ataatgagat ccacaaccgc cgcgtggccc tgggcatcac gtgcgtgcag      360

tgcacgccgg tacagctgga gattctgcgt cgggccgggg ccatgcccat ctcgtcgcgc      420

cgctgcggca tgatcactaa gcgagaggcc gaacgcctgt gcaagtcgtt cctgggcgag      480

cacaaaccac ccaagctgcc cgagaacttc gccttcgatg tggtgcacga gtgcgcgtgg      540

ggctcgcgtg gtagcttcat ccctgcgcgt tacaacagct ctcgtgccaa gtgcatcaag      600

tgcggctact gcagcatgta cttctcgccc aacaagttca tcttccactc gcaccgaaca      660

cccgacgcca agtacacgca gcccgatgcc gccaacttca actcctggcg tcgtcacctc      720

aaactcagtg acaagtcggc cacagacgaa ctgagccatg cttgggagga cgtcaaggcc      780

atgtttaatg gcggcacgcg gtgcggtgca gagatggccc caggcccgcc gccccacaaa      840

agcctgcgct gtggcgaaga tgaggctgcc gggcctccgg ggccacctcc accccacccg      900

cagcgcggac ttggcctggc gactggagct agtggcccgg cgggcccagg agggcccggt      960

ggcggcgccg gcgtacgaag ctacccggtg atcccggtgc ccagcaaagg ctttgggctc     1020

ctgcaaaagc tgcccccacc acttttcccc catccttacg gcttccctac ggccttcggc     1080

ctatgcccca aaaaggacga cccggtttta ggcgcgggcg agccaaaggg cggtcctggc     1140

actgggagcg gcggcggcgg cgcggggaca ggcgggggtg cggggggccc gggagccagc     1200

cacttgcccc cgggggcagg ggcgggcccg ggcggcggcg ccatgttctg ggggcatcaa     1260

ccctccgggg cagccaagga cgcagcggca gtggctgcag cggccgccgc cgccactgtg     1320

tacccgacgt ttcccatgtt ctggccagca gcaggcagcc tcccggtacc gtcctacccc     1380

gctgctcaga gccaagccaa ggccgtggcg gcagccgtgg cggcggcagc ggcggcggca     1440

gcggcagctg ctggcagcgg tgccccagag cccctggacg gtgccgagcc agccaaagag     1500

agtggcctcg gcgcggagga gcgctgcccg agcgctctgt cccgcgggcc cctggacgaa     1560

gacggcacgg acgaggcgct gccaccgccc ctggccccgt tgcccccgcc gcccccgccg     1620

cccgcacgca aaggctccta cgtgtcggcc ttccggccgg tggtcaagga caccgagagc     1680

atcgctaagc tctacgggag cgcccgggag gcgtacggcg cggggcctgc tcgggggccg     1740

ggacccggcg ctgggagcgg cggctacgtg agcccggact ttctgagcga gggcagctcc     1800

agctacaatt ccgcctcgcc cgacgtggac accgcggacg agcccgaggt ggacgtggaa     1860

tccaaccgct tccccgacga cgaggacgcc caagaggaga ccgagcccag cgcacccagc     1920

gcagggggcg gcccagacgg tgaacagccc actggacccc cttccgccac ctcctctggc     1980

gcggacggtc ccgcaaactc tcccgacggc ggcagccccc gcccccggcg ccgcctcggg     2040

ccacccccag ctggccggcc cgcatttggg gacttggcag ccgaagactt ggtgcggaga     2100

cctgagagga gcccgccaag cggcggcggc ggctacgagc tgcgagagcc ttgcgggccc     2160

ctaggaggcc ccgcgccggc caaggtgttc gcgcccgaga gggatgagca cgtgaagagc     2220

gcggcggtgg cgctggggcc cgcggcctcc tacgtctgca cccccgaggc ccacgagcca     2280

gataaggaag acaatcactc gcccgccgat gatttggaaa cgaggaaatc ctatccagac     2340

caaaggagta tctcccagcc aagtcctgca aatacagaca gaggcgaaga tgggcttacc     2400

ttggatgtca caggaactca tttggtggag aaagatatcg agaacctggc cagagaggaa     2460

ttgcaaaaac tgctcctgga acaaatggag ctccgcaaga agctggaacg ggaatttcag     2520

agtctcaaag ataattttca ggatcaaatg aagagggaat tggcttatcg agaagaaatg     2580

gtgcaacagc tgcaaattgt cagagatacc ctgtgtaacg aactcgacca ggagcggaag     2640

gcgcgctatg ccatccagca gaaattgaaa gaagcccacg acgccctgca ccatttctcc     2700

tgcaagatgc tgacgccccg ccactgcact ggcaactgct ccttcaagcc accgctgttg     2760

ccctag                                                                2766


<210> 2201
<211> 5068
<212> DNA
<213> Homo sapiens

<400> 2201
gagagttcag ggaggccgcc ctgagattcc ggcgaggccg cgggtcccac ctcccggggg       60

cggggcgagg gcggagcggg gagaagggag ctgacgggcg cccggccggc tgcggtccgt      120

gcggaggctg agccggccgc gggcgcgacc ggaggcagtt tccgttacta tggcaatgac      180

ggcagggact acaacaacct ttcctatgag caaccatacc cgggaaagag tgactgtagc      240

caagctcaca ttggagaatt tttatagcaa cctaatttta cagcatgaag agagagaaac      300

caggcagaag aaattagaag tggccatgga agaagaagga ttagcagatg aagagaaaaa      360

gttacgtcga tcacaacacg ctcgcaaaga aacagagttc ttacggctca aaaggaccag      420

acttggcttg gatgactttg agtctctgaa agttatagga agaggagctt ttggagaggt      480

gcggttggtc cagaagaaag atacaggcca tatctatgca atgaagatat tgagaaagtc      540

tgatatgctt gaaaaagagc aggtggccca tatccgagca gaaagagata ttttggtaga      600

agcagatggt gcctgggtgg tgaagatgtt ttacagtttt caggataaga ggaatcttta      660

tctaatcatg gaatttctcc ctggaggtga catgatgaca ttgctaatga agaaagacac      720

cttgacagaa gaggaaacac agttctacat ttcagagact gttctggcaa tagatgcgat      780

ccaccagttg ggtttcatcc atcgggatat taagccagac aaccttttat tggatgccaa      840

gggtcatgta aaattatctg attttggttt atgtacggga ttaaagaaag ctcacaggac      900

tgaattttat agaaatctca cacacaaccc accaagtgac ttctcatttc agaacatgaa      960

ctcaaagagg aaagcagaaa cttggaagaa gaacaggaga caactggcat attccacagt     1020

tgggacacca gattacattg ctccagaagt attcatgcag actggttaca acaaattgtg     1080

tgactggtgg tctttgggag tgattatgta tgaaatgcta ataggatatc cacctttctg     1140

ctctgaaaca cctcaagaaa cgtacagaaa agtgatgaac tggaaagaaa ctctggtatt     1200

tcctccagag gtacctatat ctgagaaagc caaggactta attctcagat tttgtattga     1260

ttctgaaaac agaattggaa atagtggagt agaagaaata aaaggtcatc ccttttttga     1320

aggtgtcgac tgggagcaca taagggaaag gccagcagca atccctatag aaatcaaaag     1380

cattgatgat acttcaaatt ttgatgactt ccctgaatct gatattttac aaccagtgcc     1440

aaataccaca gaaccggact acaaatccaa agactgggtt tttctcaatt atacctataa     1500

aaggtttgaa gggttgactc aacgtggctc tatccccacc tacatgaaag ctgggaagtt     1560

atgaatgaag ataacattca cccataacca agagaactca ggtagctgca tcaccaggct     1620

tgcttggcgt agataacaat acactgaaat actcctgaag atggtggtgc ttattgacta     1680

caagaggaaa ttctacagga ttaggatttc taagactact ataggaattg gttggcagtg     1740

ccagctggct ctttttttta atattttatt atttttgtta actttattat atgaaggtac     1800

tggaataaaa ggaacagaca tccctttcta actgcactgc ctacatgcgt attaaggtcc     1860

attctgcctg tgtgtgctgt ggctttgaac tgtaacacct ctaatcaatt caggagaaac     1920

acatatcatt taaagcaaca taggctaacc tgtaggtaac actgcagtat tgatgtttta     1980

ctgcaaatct tatgggtcta gataatcagt aaaagccatc ttccatagtt ggtgttagaa     2040

cattgcccta ttggtttgga catctgtaga atatatatga agacaatttc tgtaatggtt     2100

ttaagagatt taaaaagaaa ttcactggtt ctttacaaaa tagaatttat catcaagtta     2160

ttacacaaac ttcacagtaa ggagtgacaa gtttataata aggaagacaa agtttaacac     2220

cttcactcaa gcactccact aatatattta cgttgcattc agaaatactg atgaccttca     2280

tatacgtagt ctgtatactc atagggagat gtactgtatt atataacatg taaagttgat     2340

tttcttgtga caagagaact tcttttttta acaagaggac atggcattat tttaatttga     2400

ttatggtgag ttgaatttaa gacatgacca tgaaggctgc ttgtagaatt agtgtatttt     2460

tattaaacta tttttttaaa tgtcaaactt ctatcatgta aatggactta tagagaacaa     2520

aaagctattt actttggttt tctagaaagt tgttacatat catggctggt taacttttat     2580

ttcttttgat gaaaattttt cctttgatag tacttgtatt attgtgccat tattttctta     2640

tgctccaaat gtaccaaaga tcttgaacag agtggatgtt cacaactgag tagaattttc     2700

ctttcctgtg ggcatgctgt attcagacct gacagatctt tgatagaggt cagcttatta     2760

aagggcaata ttgttcttgt ttagctacat cactgtggtg aatatagatg gaattaagga     2820

agtaaatgca ggccaggggg ttgtgatgag aggatagggg agataatatc agcatcaaat     2880

tctttgggta tctctctaag aattaaataa tcttttctag cttaatattt taattctaat     2940

tcaaacaact ctgaggtttt ggtttcatta gtaatagttg aggaataata tactagcaaa     3000

gaatggccta atgtttgtca taactgttaa tggatgaaat tttttaaaga tacaaccatg     3060

ataaccatta taaatgatct atgatcaaaa tctaaagtga tgaattattt gtaggaatgt     3120

cttcctaatg gggaagaatt gcataggagc attatgcaaa tctacacaag cttttataaa     3180

tgttgctgct gggtagctcc acagtgtttc ataaggccat cctgtttccc ccaactcccc     3240

catttttggt ttgtttcttt ttaaatattt gttgagtact tacgtgttta tctaacagtt     3300

cacttccatt tttctagtct ggattttttg agtatttagg aaagagagct attaaaaact     3360

ggggatttct caatgtgact aactctaatt tttctaatta taactgcctt taattaacat     3420

aatattaact tttgctgagg tttatgagat tttctcaccc cacatcgctc cccttttttt     3480

aaaaaggact gttttgctag tgtgataatg aataggtaag atatgagata attgcaacat     3540

tgtctagttc tagtatggta actattcttg aaatggtatt gaaaaatacc gttaattcaa     3600

attgacagag attgataaaa agaaactgat ttacctaagt ttacttttta attgcataat     3660

agagcatttt ttgttttgag ttccctcatt cttattacca gaaagagctt gcaaatagtt     3720

ttactttctt ggcactggaa gggtagttct ggaaagctac tttgttgaga gtctcattct     3780

tccctggagt taatagagtg attcacaatc tttggggttt tctcctcatc aaaagcattt     3840

cttaagtgcc tatctaaaag caattaaaga ctgtgtctgc cctttagaag ctaagaattt     3900

gattcatgat gcaaattaac tagataattt gcaaagtacc cttgagattg aattttctct     3960

attatatatt tcccatattt caggtgaata atttaattta aatgacaaaa ccctatctag     4020

tcaactgggc ataatgacat tttctttaaa ttagactcta ttttgaatta aaagagtttt     4080

attataaacc gtgtgttttt ggtttttcta agtatataga aagcttgtat aattcagatt     4140

tatcaatttc ctgatttaat gtagactttg acttttttat taaaaacctt tgtattaaag     4200

caagttatgt tatttttctt ttatgcattt attactaaca tagctttaaa tctttaaatg     4260

tattgaagca ttgtgctgtc tgaaaataag gaattgctta taaaccagcc acttctgaat     4320

acaatatgta gctgatttaa taagctagtt agtgaatgga aaataagtgt ggagtattaa     4380

aaatgttctt tggttggtaa ggcctaagat agggtttcat ttatttctat actttttctg     4440

ttttttaaac acctgcatat ttttatgtaa atctctaaat ttaaaatatt ttaagtacat     4500

ttatttttgg tgttttattg tataaaacct tagacaatca atcagtcagt ctttactgac     4560

aggagcagca gctatctgtc ttttgctgat ctacaaataa atgaattgag aatttagtcc     4620

atagaggtcc ctggctacca aacacattct cctttgaatt gttaaaattc agaacattca     4680

aaataactgt tttgctacaa cccatgatta ttttcctgtt gtgtttattt aaatttactt     4740

tctctttaga agtgcactta tttctgaaaa atcttaatga aacaaacgct tagaacaaat     4800

ataaatatga gacacttggg actactagag atattttaga tttttatgaa aaaaatgtga     4860

ggggatattg ctgctttaaa aaggaataaa gtaataaaaa tatatctcag ctattttttt     4920

aaagcaatat aattcagcaa ttgtctagaa aagtaatcat gaggctactg agtttggtgt     4980

tcagttactg agtttcaaaa atgttttggt ggcatgagga caaaatttca ttgaaggtaa     5040

gataagaata aaaactatgt ttacaaaa                                        5068


<210> 2202
<211> 4057
<212> DNA
<213> Homo sapiens

<400> 2202
cctgaacgga cgccgtagcc aagaggttgg gcggatgttg tgagccgggt cgctgcggcc       60

gaggctccgg cccccaggac cactggctgc ccatgagaga tgaaggatgg catccaaggg      120

ggccggcatg tctttctccc gcaagagcta taggctgacc tcagatgctg agaaatccag      180

ggtcacaggc attgtgcagg agaagctgct gaatgactac ctgaaccgca tcttttcctc      240

ttctgaacat gcacccccag cagccaccag caggaaaccc ctgaacttcc agaacctgcc      300

agaacatttg gaccagttgc tacaggtgga caatgaggag gaggaaagcc agggacaggt      360

tgaagggcgg cttggcccat ccactgtggt cctggaccac acaggcggct ttgaggggct      420

tctcctggtg gatgatgacc tgctgggggt gattggacac agcaactttg gcaccatccg      480

ctctaccaca tgcgtgtaca aagggaaatg gctctacgag gtcctcatct cctcccaggg      540

gctcatgcag atcggctggt gcaccatcag ctgccgcttc aaccaggagg agggggttgg      600

agatacacac aactcctatg cctatgatgg caaccgcgtg cgcaagtgga atgtgaccac      660

aacgaattat ggcaaggcgt gggcagcggg ggacatcgtg agctgcctga ttgacctgga      720

tgatggcact ctgtccttct gcctgaacgg tgtatcactg ggcactgcct ttgagaacct      780

gtccaggggc ctgggtatgg cctacttccc agccatcagc ctctctttca aggagtccgt      840

ggccttcaac tttggcagcc gtcctctgcg ctacccagtg gcaggctacc ggcccctgca      900

ggacccaccg agtgctgacc tggtgcgggc acagaggttg ctgggctgct tccgggcagt      960

gctgagtgtg gagctggacc ctgtggaggg gcggctgttg gacaaggaga gctccaagtg     1020

gcggttgcgg ggccagccca ccgtcctcct cacactggcc cacatcttcc atcactttgc     1080

accgcttctg cgcaaggtgt atctggtgga ggctgtgctc atgagcttct tgctgggcat     1140

cgtggagaag ggcacaccca cacaggcaca gtccgtggtg caccaggtcc tggacctctt     1200

gtggctcttc atggaggact acgaggtaca agattgcctc aagcagttga tgatgtctct     1260

gcttcggctg taccgattct cacccattgt cccagacctg ggcctacaga tccattacct     1320

gcggctcact atcgccatcc tgaggcatga gaagtcccgc aagtttctgc ttagcaatgt     1380

cctcttcgac gtgctccgct ccgtcgtctt cttttacatc aagagccccc tgcgtgtgga     1440

ggaggccggc ctgcaggagc tcattcccac cacctggtgg ccccactgct ccagtaggga     1500

gggcaaagag agcacggaga tgaaggagga gaccgcagag gagcggctgc ggcggcgagc     1560

ctacgaacgg ggctgtcagc ggctcaggaa gcgcatcgaa gtggtggaag aactacaggt     1620

ccagatcctg aagctgctgc tggacaataa agatgacaat gggggtgaag cttctaggta     1680

tatcttcctg accaagtttc gcaagtttct gcaggagaac gccagtggcc gggggaacat     1740

gcccatgctc tgcccccctg agtacatggt ctgcttctta caccggctga tctctgccct     1800

gcgctactat tgggatgaat acaaggcttc caatcctcat gcttccttca gtgaggaggc     1860

ctacatcccg ccccaggtct tctataatgg caaggtggac tactttgacc tgcagcgcct     1920

ggggggcctc ctctcgcacc tgcggaagac cctcaaagat gaccttgctt ccaaagccaa     1980

cattgtgatc gacccactgg agctccagtc aaccgccatg gatgacctag atgaggatga     2040

ggagccagcc ccagctatgg cccagcgccc catgcaggcc ctggctgttg gggggccact     2100

gcccctgccc cggcccggct ggctcagttc tccaactttg ggccgagcca accgcttcct     2160

cagcacagcg gctgtgagcc tcatgacccc acggcggcct ctgagcacct cggagaaagt     2220

gaaggtccgc acgctgagcg tggagcagag gacccgtgag gacattgaag gcagccactg     2280

gaatgagggc ttgctgctgg ggcggccccc cgaggagcct gagcagcccc tcaccgagaa     2340

ctcgctgctg gaagtcctgg atggggcggt catgatgtac aacctcagcg tacaccagca     2400

gctgggcaag atggtgggtg tctccgatga tgtcaatgaa tacgctatgg ctctgaggga     2460

cacagaggac aagctccgcc ggtgccccaa gaggaggaag gacatccttg cagagttgac     2520

caagagccag aaggttttct cagaaaagct ggaccacctg agccgccgtc ttgcctgggt     2580

ccatgccact gtctactccc aggagaagat gctggacatc tactggctgc tgcgcgtctg     2640

cctgcggacc attgagcacg gtgatcgcac agggtctctc tttgccttca tgcccgagtt     2700

ctacctgagc gtggccatca acagctacag tgctctcaag aattactttg gtcccgtgca     2760

cagcatggag gagctcccag gctatgaaga gaccctgacc cgcctggctg ccattctcgc     2820

caaacacttt gccgacgcac gcattgtggg cactgacatc cgagactcac tgatgcaggc     2880

cctggccagc tacgtgtgct acccacactc cctgcgggct gtggagcgaa tccccgagga     2940

gcagcgtatc gccatggtga ggaacctcct ggcgccctat gagcagcggc cctgggccca     3000

gaccaactgg atcctggtgc ggctctggag gggctgtggc ttcgggtacc gctatacacg     3060

gctgccacat ctgctgaaaa ccaaacttga ggacgccaat ttgcccagcc tccagaagcc     3120

ctgcccttcc accctgctgc agcagcacat ggcggacctc ctacagcagg gtcctgatgt     3180

ggcacccagc ttcctcaaca gcgtcctcaa tcagctcaac tgggccttct ctgaattcat     3240

tggcatgatc caagagatcc agcaggctgc tgagcgcctg gagcggaact ttgtggacag     3300

ccggcagctc aaggtatgtg ccacctgctt tgacctctcg gtcagcctgc tgcgtgtctt     3360

ggagatgact atcacactgg tgcctgagat attccttgac tggacccggc ctacctctga     3420

gatgctgctg cggcgtcttg cacagctgct aaaccaggtg ctgaaccggg tgacagctga     3480

gaggaacctg tttgatcgtg tggtcaccct acggctgcct ggcctagaga gcgtggacca     3540

ctatcccatt ctggtggcag tgacgggcat cctggtgcag ctcctggtgc gtggcccagc     3600

ctcagagaga gagcaagcca catcagtgct cctggcagat ccctgcttcc agctacgctc     3660

aatatgctat ctcctgggac agccagagcc cccagcacct ggcactgctc tgccagcccc     3720

tgaccggaag cgcttctccc tgcagagcta tgcggattat atcagtgccg atgagctggc     3780

ccaagtggaa cagatgctgg cgcacctgac ctctgcatct gcccaggcag cagctgcctc     3840

cctgcccacc agtgaggagg acctctgccc catctgctat gcccacccca tctctgctgt     3900

gttccagccc tgtggccaca agtcctgcaa agcctgtatc aaccagcacc tgatgaacaa     3960

caaggactgc ttcttctgca aaaccaccac atccaacctc cttgcctgcc tgtatcctca     4020

ttggtgggag cccagccatg gccctaattg tgcctga                              4057


<210> 2203
<211> 5078
<212> DNA
<213> Homo sapiens

<400> 2203
atgccgtcgg tttcgaaagc ggcggcagcg gcgctgagcg ggtccccccc gcagactgag       60

aagccgaccc actacaggta cctgaaggag ttcaggacgg agcagtgccc cctgttttca      120

cagcacaagt gcgcgcagca ccggccgttc acctgcttcc actggcactt cctcaaccag      180

cggcgccgca ggcccctccg caggcgcgac ggcaccttca actacagccc cgacgtgtac      240

tgctccaagt acaacgaagc caccggcgtg tgccccgacg gcgacgagtg tccctacctg      300

caccggacga cgggggacac agaacgcaag taccacctgc gttactacaa aacaggaacc      360

tgcatccacg agacagacgc acgtggccac tgcgtgaaga atgggctgca ctgtgccttc      420

gcgcacggcc ccctggacct gcggccgccc gtgtgtgacg tcagggagct gcaggcccag      480

gaagccttgc agaacggcca gctgggcggc ggggaagggg tcccggatct gcagcctggg      540

gtcttggcca gccaggccat gattgagaag atcctgagcg aggacccccg gtggcaagat      600

gccaacttcg tgctgggcag ctacaagacg gagcagtgcc cgaagccgcc acgcctgtgc      660

cgccagggct atgcgtgccc acactaccac aatagccggg acaggcggcg caacccccgg      720

cggttccagt acaggtccac gccctgcccc agtgtgaagc acggggatga gtggggggaa      780

ccctcacgct gcgatggcgg cgacggctgc cagtattgcc actcccgcac ggagcagcag      840

ttccatcccg agtctacaaa atgcaacgac atgcgccaaa ccgggtactg cccgcgcggc      900

cccttctgtg cctttgcaca cgttgagaag agcctgggga tggtgaatga atggggctgt      960

cacgacctcc acctcacgag tccttcctcc acgggcagcg gccagccggg aaatgccaag     1020

cggagagact cgccggccga gggtggccct aggggcagcg agcaagacag caagcagaac     1080

cacctggccg tgtttgcagc ggtccacccg ccggccccca gcgtgagctc cagcgtggcg     1140

tccagcctgg cgtccagcgc cggctccggc agctcctccc ccactgcgct gcccgcgccc     1200

cccgcccgtg ccctcccgct cggccccgcc agcagcactg tggaggccgt cctcggttct     1260

gcgttagacc tgcatcttag caatgtgaat attgcatccc tagagaagga cctggaagag     1320

caagacggcc acgacctggg agcagcaggt cccaggtcgc tggccggctc tgcacctgtc     1380

gccatccccg gctccctgcc cagagcacca tcgctacact cgccatcctc tgcgtccacc     1440

tcgccgctcg gttcgctgtc ccagcccctc ccagggccgg tgggctcctc agccatgacg     1500

cctccccagc agccgccacc cctgcgttca gagccgggca cactgggctc tgcagcctca     1560

tcctacagcc ccctaggttt gaacggtgtc cccgggagca tctgggactt tgtttccggc     1620

agcttctccc ccagcccctc ccccatcctg agtgccggcc ccccatcctc ttcgagtgca     1680

agtccaaacg gagctgagct ggcccgggtc aggcggcagc tggacgaggc caagaggaag     1740

atccggcagt gggaggagtc ctggcagcag gtgaagcagg tctgcgatgc ctggcagcga     1800

gaggcgcagg aggccaagga gcgtgcccgt gtggccgata gcgaccggca gctggcgctg     1860

cagaagaagg aggaggtgga ggcacaggtg atcttccagc tccgcgccaa gcagtgtgtg     1920

gcctgccggg agcgggccca cggtgctgtc ctgcggccct gtcagcacca catcctctgt     1980

gagccgtgtg cggccaccgc acctgagtgc ccctactgca agggccagcc cctgcagtgg     2040

tgacctcagc ggggacagcc acctcctgct gggcaccctg gctccagcgc tcctcctgac     2100

cacggacatg tcgtcactcg cttctggtgc caccgacgtg aggaccgagg ctgggagccc     2160

ttcctgttac acgttatcat gaggctggga gccccgcctg cgcttggcct gacagccttt     2220

cctgtcacac gttgtcacct atctagtcct accgacggtt tcaaggtatt ttcctcaaaa     2280

accttaaatg caaacccaca gaacccgcct gcctgtccct gaggggcctg gtgcctccgg     2340

gatccacgcg gcgctgtgat cacagcagtt tgtggtcctg acactactgt gactaggcca     2400

ctgggagctg gggtctttca aagcactttg taaaccgagg aatttagtta gaggttataa     2460

attgctctaa gctgctttct gttttttttt aatatgcgat aatatgaagc tttatatgtg     2520

tactgtgaac ttaaatattt catatcagtt tattgtcaat tcatagtatg ctaaatatat     2580

tagatttcat attctgaaac tagtacttat gaaatgagtg tttatctagt agtaagacct     2640

aggattttta cattttccaa ttaagtgcaa atagtattta taagcagagt gattatggat     2700

tgagatgttt ttaacttgat ggaaggagct agttttcctg agcctgtgtg tgcaccaggc     2760

actggggctg atgttccagc ctcgtggcgt gggagcagga gagctccgtc ctgcatttct     2820

gtggtccgtg gccgctgttt ctgtgcgcct gcgcctcgga gagcaagtga aggagcatca     2880

tgggttttgt tttctccctt aaccctctga aagacagttt gatactaaca aaaaacgcag     2940

cagaggggat ccgacgtcag agcttttaga attacttttt taagcagctg tcttctggct     3000

gggtgcggtg gctcatgcct gtgatcccag cactttggga ggcgggtgga tcacctaagg     3060

tcaggagttc aagaccagcc tggccaacat ggtgcaaccc cgtcttagta aaaatacaaa     3120

aattggcctg gcgtgagagc gggcacctgt agtcccagct actcgggagg ctgaggcagg     3180

agaatcgctt gaacctggga ggcagaggtt gcagtgagcc gagatcgcgc caccgcactc     3240

cagcccgggt gacagagcga gactctggct caaaaaaaaa aaaaaaaagc tgttttctga     3300

ttactcagag ctgtcctagg caatggtgct ttgtagctcc ttggagatgt cgctgggcgt     3360

cctggcaggg gtcaggcagt gaactgggag agtggttgcc tccccagcac ccgtgaccac     3420

cctggtcctg ctcgtgtggg agatgctcgg gccgtgtgtg cgccagggtc cggggtgccg     3480

ggtgtatgtg gcagtcacct gacccgcgct gccagttatc atcggagctc atccatgtgg     3540

ccagtgaggt cacaggagag gacccggcca cagcctctca gtggcctgga gcacacgggg     3600

gaagcgaccc cccccaggtc ccggctctgc tgtggtcccc tgtcccgtct gcccctggag     3660

cgacagtgtg gtttcggccg cagcagaaac gtgactgaga acgcatcccc gcgatgacct     3720

gacccttctg ctcagggctg ggactgtccc taggagttga gcaggaacag gcatctgtgg     3780

tttacggcga cctggctctc cgcgggccac gtgggtggtg agggcacacg agtgggaagc     3840

ggcaccgacg tgtttctccc cgaccgtggc tttgccaaag acttttaata gcatttttta     3900

agtgcaaaac gtctaggtaa aaatctttat catcagtgac caaattagaa tgtatttaat     3960

atagtaggtg gtttaagaac tgttttaacg taagacaaac tgatagcaac attctgttgt     4020

tttaaaggaa gtgggtccgt gacattctgc agctagtcca ctactccaag gtaactatcg     4080

acttggtttc agtgaatcta ttttgttttt aactacagtg atttattagc tcagtatcta     4140

gaaattacgt atattttgtg ctactgtcat cgatgtgtaa actctgtttt tatttgtatt     4200

tatgcacttg gttcccattt ggagcctctg gtcttttctg ggataagtgg tgtctgccga     4260

gacatctccc ggttgtcagt ggtcaggagc agctgagctc tagtctgcca gctgctctgc     4320

tctttctggg aaggaggtgg cgcccgcccc tcagggtgtc tccagggctc agcttccggg     4380

gtggtagagc tggggagccc caggggtggg gggacagctg ggagatggag gtggcacctg     4440

ctcccctaga tcagtactgg ctctgaggac aggtgagcag tgggaagacc aaagaatggc     4500

tggcagcgct gccagggttg gaaatggggg caagatcctg gggctgtgtg ccctggggcc     4560

tccctcacct gtcttggtgg ccatggcctc agggatggct cctaggtggc tgaggcacag     4620

cagtggctgg aaggtgcccc gtggaggctg aggtggaggc gcgcccagca gctcccccct     4680

gtggccatgg cgggcacggg gcgtaggagc tggctggcgg ccggctctgc atgttcttgt     4740

tgcctgtcgt ctgtaactct agtgttcgac attcgccgtg atacagtggt gtcacgacgt     4800

gtgtaactgt ggtcagcaga ccttgttccg cgtggacgcc tcaagtggat taatttctgg     4860

aagcctcaat ctgtatgttt gagtatttac atgagaatgt tatttgaatg gaattttctt     4920

aacccagaag gtagtattta taatcattta cttgtagcga actgtttaaa gttaacactt     4980

gtttaaattt ttttacacta tagcatttat gcaatggttt acagaattca tggagttatt     5040

tttatcagta tgggaattaa ttaaaacctt gaatcttt                             5078


<210> 2204
<211> 1510
<212> DNA
<213> Homo sapiens

<400> 2204
acaagatggc ggcgctgcgg gacggctagc ggccctgcgt gggagttcct gacagctgga       60

ttctagaagt agaactatga gctcaccttt ggcctccctt agcaagaccc gaaaagtgcc      120

cctgccctcg gagcctatga atcctgggag gcgaggaatc cgcatctatg gagatgtccc      180

tgcatcccat gactcggagc tgatggcctt catgacgagg aagttgtggg acctggagca      240

gcaggtgaag gcccagactg atgagatact gtccaaggat cagaagatag cggccctaga      300

ggacctggtg cagaccctcc ggccacaccc agccgaggca accctgcagc ggcaggagga      360

actggagacg atgtgtgtgc agctgcagcg gcaggtcagg gagatggagc ggttcctcag      420

tgactatggc ctgcagtggg tgggcgagcc catggaccag gaggactcag agagcaagac      480

agtctcagag catggcgaga gggactggat gacagccaag aagttctgga agccagggga      540

ctcattggcg ccccctgagg tggactttga caggctgctg gccagcctgc aggatcttag      600

tgagctggtg gtagagggtg acacccaagt gacaccagtg cccggcgggg cacggctgcg      660

taccctcgag cccatcccgc tgaagctcta ccggaatggc atcatgatgt tcgacgggcc      720

cttccagccc ttctacgatc cctccacaca gcgctgcctc cgagacatat tggatggctt      780

ctttccctca gagctccagc gactgtaccc caatggggtc ccctttaagg tgagtgactt      840

gcgcaatcag gtctacctgg aggatggact ggaccccttc ccaggcgagg gccgtgtggt      900

gggcaggcag ctgatgcaca aggccttgga cagggtggag gagcacccag gctccaggat      960

gactgctgag aaatttctga acaggctccc caagtttgtg atccggcaag gcgaggtgat     1020

tgacatccgg ggccccatca gggacacctt gcagaactgc tgcccattgc ctgcccggat     1080

ccaggagatt gtggtggaga cgcccacctt ggccgctgag cgagagagga gccaggagtc     1140

acccaacacg ccggcacccc cgctctccat gctgcgcatc aagtctgaga atggggaaca     1200

ggccttccta ctgatgatgc agcctgacaa caccattggg gacgtgcgag ctctgctagc     1260

gcaggccagg gtcatggatg cctctgcctt tgagatcttc agcacattcc cgcccaccct     1320

ctaccaggac gatacactca cgctgcaggc tgcaggcctt gtgcccaaag cagcactgct     1380

gctgcgggca cgccgagccc cgaagtccag cctgaaattc agtcctggtc cctgtccccc     1440

cggtcccggt cccggcccca gtccctgtcc tggacccagt cccagccccc aataaagcac     1500

ccgccccctc                                                            1510


<210> 2205
<211> 2382
<212> DNA
<213> Homo sapiens

<400> 2205
atgggccagt gctataattt ggaggatgat gacttggaaa cagacgtgaa caagctgagt       60

tccaaacctg gtcttgaccg acctgaagag gaactgatgc aatatgaggt gatgtgtctt      120

gagctctcct atagctttga ggaactgcag tccaaacttg gagatgattt gaactctgaa      180

aagactcagt atgccaatca ccaccacatt ccagccgctg cctcctcaaa acagcattgc      240

tacagcaagg accaaagctc ctgtgggcaa gaaagagaat atgctgtcca gacttccctt      300

ctgtgcaggg tgaagacggg aaggtccact gtgcatctag gctccaaaaa aaatcctgga      360

gtgaacctgt accaaaatgt gcaatccaat agtctcagga gagattcttc tgaaagtgaa      420

atccctgaca ttcaggcttc cccgaaagca gatgcctggg acgtagatgc aattttctgc      480

ccaaggatga gtgcctcctt ttctaattcc actaggacta gagaagttgt caaagtaata      540

gataagcttc tgcagacaca tctgaagcgt gtccctttcc acgatcccta tctttatatg      600

gccaaagcca gaagaaccag ctctgtggtg gacttcaaga tgatggcatt tcctgatgtc      660

tggggacact gtccccctcc caccacccag cctatgttgg aacgaaaatg tggagtccaa      720

aggatcagga tatttgagga tattcggagg ctcatccagc caagtgatgt tataaataaa      780

gttgtcttca gtttagatga gccttggcct ttgcaagaca atgcttccaa ttgtttacgg      840

ttcttctcca aatttgagtc aggaaatctt cgcaaagcca tccaagtgcg tgagttcgag      900

tatgacttgc tggtcaacgc agatgtgaat agcacccagc accagcagtg gttctatttc      960

aaagtgagcg gtatgcaggc ggccatccct taccacttca acatcatcaa ctgtgagaag     1020

cccaacagcc agtttaatta tgggatgcag cccaccctat attctgtgaa ggaggctctt     1080

cttggcaaac ccacctggat aaggacaggc catgaaatat gttattacaa aaatcattat     1140

cgccagagta cagctgttgc aggcggagca tctgggaagt gctactatac cctcaccttt     1200

gctgtcacct tcccacacag tgaggatgtc tgctacctgg cctaccacta tccctatacc     1260

tacacagccc tcatgactca tcttgacatc ctggaaaaga gtgtcaacct caaagaggtc     1320

tacttccggc aagatgttct ctgccagacg ctgggaggga atccgtgtcc cttggtgacc     1380

atcacggcca tgcctgagtc caacagtgat gagcatctag agcagttccg acatcgtcca     1440

tatcaggtga tcactgctcg agttcatcca ggagagagca atgccagttg ggtgatgaag     1500

ggtaccttgg agttcctggt cagcagtgac cctgtggcta ggctcttgag ggaaaacttc     1560

atcttcaaga tcatacccat gctcaaccca gatggtgtca tcaacggcaa ccacagatgc     1620

tcactgagcg gggaagattt gaacagacaa tggctttctc ccagtgctca tctgcagcca     1680

accatttacc atgccaaagg cctcctctac cacctgagca gcattggccg aagtcccgtg     1740

gttttctgtg acttccatgg ccactcccaa aagaagaatg tgttccttta tggctgtagc     1800

atcaaggaaa ccttgtggca agcagcatgc actgtgggca catctactat cctagaggag     1860

gtcaactaca ggactcttcc caaaatcctt gataagctag caccagcatt cacaatgagc     1920

agctgcagct ttctcgtgga gaaatctcga gcttccacgg cccgggtggt ggtgtggaga     1980

gagatggggg tgtccagaag ctacaccatg gaaagcagct actgtggctg caaccagggc     2040

ccttatcagt gtacacagag gctgttggag aggacaaaga atgaaagggc tcacccagtg     2100

gatggccttc agggtctaca gtttggtacc agagaactgg aggagatggg agccatgttc     2160

tgtttgggcc tcctcatcct ggagctcaaa tctgccagct gcagccatca gctcctggct     2220

caagctgcaa ctctgctgag tgctgaggag gacgctctgg accagcacct ccaacgatta     2280

aaatcatcca atttcctgcc aaagcatatt tggtttgctt accacttttt tgccattaca     2340

aactttttca agatgaacct tcttctgcat gtctccccgt ga                        2382


<210> 2206
<211> 575
<212> DNA
<213> Homo sapiens

<400> 2206
cgcgcttggc aacggctcgg cgtcgcgctt tggccaaccg ctgcgtcgtc cctgggcccg       60

aataactgtc gcccgcttcc ctcagcgtga ggtgaagcac ttcaaattgc ctgatgaaag      120

ttgaatcagg aatgaagata aaagtacaca acaatgcaga aagcggtact tagcctcaca      180

aagatggaaa cattccaaaa acgtgaagta ctgttgtccc aagattcttt ctaagcctaa      240

aattacactt ttactagtcc gattttctgg ttgtgagttt tttttgtttg tttttttttt      300

ttcgagaaac tgcagtaggc ttcttggaag tagaccaagg gtgtccaatc tttggcttcc      360

ctgggccaca tcggaagaag aattgtcttg ggccacacat gaaattcaca aacactaagg      420

tacaaatgat gcaaaatgtg cacctggctc cagagacaga tgaagatgat ctttattccg      480

gctataatga ctacaatcca atctatgata tcgaggaatt ggagaatgat gcagcttttc      540

agcaagctgt gaggactagt catggcagaa gacct                                 575


<210> 2207
<211> 3054
<212> DNA
<213> Homo sapiens

<400> 2207
cgcaccaccc ccttcccgcc gcgctctctc ccgcccccgc gcttccggcc ccgcccgccc       60

ccgcgcggag gactgtggga gcggcttcct tggattccgc gcttggcaac ggctcggcgt      120

cgcgctttgg ccaaccgctg cgtcgtccct gggcccgaat aactgtcgcc cgcttccctc      180

agcgtgaggt gaagcacttc aaattgcctg atgaaagttg aatcaggaat gaagataaaa      240

gtacacaaca atgcagaaag cggtacttag cctcacaaag atggaaacat tccaaaaacg      300

tgaaaaactg cagtaggctt cttggaagta gaccaagggt gtccaatctt tggcttccct      360

gggccacatc ggaagaagaa ttgtcttggg ccacacatga aattcacaaa cactaaggta      420

caaatgatgc aaaatgtgca cctggctcca gagacagatg aagatgatct ttattccggc      480

tataatgact acaatccaat ctatgatatc gaggaattgg agaatgatgc agcttttcag      540

caagctgtga ggactagtca tggcagaaga cctccaataa ctgctaaaat atcaagcacg      600

gcagttacta gacctatagc tactggatat gggtccaaga catctctggc atcatcaata      660

ggaagaccaa tgacaggggc tattcaggat ggagttacta gacccatgac agcagtgaga      720

gcagctggtt ttaccaaagc agctttgaga ggctctgcat ttgaccccct tagtcagtca      780

aggggccctg cttccccttt ggaagccaag aaaaaagata gcccagagga aaaaataaag      840

caattagaga aggaagtaaa tgagttggta gaagaaagct gtattgccaa tagttgtgga      900

gacttaaaat tggccttaga aaaggcaaaa gatgcaggaa gaaaagagag agtcctggtg      960

agacagcgag aacaagttac aactccagaa aatatcaatt tggatttaac ttactcagtt     1020

cttttcaatt tggccagtca gtattcagtt aatgaaatgt atgccgaagc acttaacact     1080

tatcaagtta tagtcaaaaa taagatgttt agcaatgcag gaatattgaa aatgaatatg     1140

ggaaatatct atttaaagca aagaaattat tccaaagcca ttaaattcta ccgaatggca     1200

ttagaccaag ttccaagtgt caataagcaa atgaggatta aaataatgca gaatattgga     1260

gttacattta ttcaggctga ccgagaaaaa atgaagaagg cattccaaaa attgattact     1320

gttccattag aaattgatga agataaatat atttcaccaa gtgatgatcc tcatactaac     1380

ttagtaactg aagctataaa aaatgatcac ctcaggcaaa tggaacgtga aaggaaagcc     1440

atggcagaaa aatatattat gacatctgca aaactcattg ctcctgtaat tgaaacatct     1500

tttgctgcag gttatgattg gtgcgtggaa gtggtgaaag cttctcaata tgtagagcta     1560

gccaatgatc tggaaataaa caaagcagtt acatacttga gacaaaaaga ctataaccaa     1620

gctgtagaga tcttaaaagt gttggaaaaa aaggacagta gagtgaaaag tgcagctgca     1680

accaatctct cagccctgta ttatatggga aaggattttg cacaagccag cagctatgca     1740

gatatagctg tgaactctga tagatataat ccagcagctc ttactaataa agggaataca     1800

gtttttgcaa atggtgatta tgagaaggcc gctgaattct ataaagaggc tctaagaaat     1860

gattcttctt gtactgaagc actttataat attggcctta cctatgagaa actaaatcgg     1920

ctagatgagg ctttggactg tttcctgaaa cttcacgcaa tcctacgaaa cagtgccgaa     1980

gttctttacc agatagcaaa tatatatgaa ttaatggaaa atcccagtca agctattgaa     2040

tggctaatgc aggtggtcag tgttattcca accgatcctc aagttttatc taagctagga     2100

gaattatatg atcgtgaagg agataaatct caagcatttc aatattacta tgagtcatat     2160

aggtattttc cttgtaatat tgaagtcatt gagtggcttg gagcctatta cattgacacc     2220

caattttggg aaaaagctat tcagtacttt gaaagagctt ctcttataca gcctacacaa     2280

gtgaaatggc agctgatggt agctagttgt ttcagaagaa gtggtaacta ccaaaaagca     2340

ttagatactt acaaagatac tcacagaaaa tttccagaaa atgtcgaatg tctgcgtttc     2400

ttagttcgtc tctgcacaga tcttggatta aaagatgctc aagaatatgc cagaaaactg     2460

aagaggttgg aaaaaatgaa agaaataagg gaacagcgca taaagtcagg cagagatggc     2520

agtgggggct cccgtggcaa aagagaagga agtgctagcg gtgatagtgg ccagaactat     2580

agtgccagta gtaaaggtga acgactaagt gccagactca gagctttacc tgggacaaat     2640

gaaccttatg aaagtagcag taacaaagaa atagatgcct cctatgtgga cccacttggc     2700

cctcaaatag aacgaccaaa aactgcagcc aagaaaagga tcgatgagga tgattttgct     2760

gatgaagaat taggagatga tttgcttcca gaataatatt cactttaata tttattaaag     2820

gaaagaaatt gccttatgag atcatcctca tgttaaacct tggattaaat atctaacctg     2880

taattatttt ttttcactgt caaaacttaa gtaagtgtat tctattctgt atgtatgcat     2940

ttaagttgtt tttttctttt aaggaataaa aacaggtaaa actaatactt taggccagtg     3000

acttccttag ctttttgaaa acattgacac acaggaagaa ataaatttca taac           3054


<210> 2208
<211> 3270
<212> DNA
<213> Homo sapiens

<400> 2208
caatggcggc ggccgcggcg gagcagcaac agttctacct gctcctggga aacctgctca       60

gccccgacaa tgtggtccgg aaacaggcag aggctagaca aatggccgcc gttctcctaa      120

gacgtctctt gtcctctgca tttgatgaag tctatccagc acttccctct gatgttcaga      180

ctgccatcaa gagtgagcta ctcatgatta ttcagatgga aacacaatct agcatgagga      240

aaaaagtttg tgatattgcg gcagaactgg ccaggaattt aatagatgag gatggcaata      300

accagtggcc cgaaggtttg aagttccttt ttgattcagt cagctctcaa aatgtgggac      360

tgcgggaagc tgcccttcac attttctgga actttcctgg aatttttggg aaccagcaac      420

aacactattt agatgtcatc aaacgaatgt tagttcagtg tatgcaagat caggaacacc      480

cgtcgatcag gacgttatct gctagagcta cagctgcatt tatacttgca aatgagcata      540

atgttgctct gttcaaacat tttgcagact tgctaccggg attcctacag gcggtaaatg      600

actcgtgcta ccagaatgat gattctgtcc taaaatccct cgttgagatt gcagatactg      660

ttccaaagta tttgcgtcct cacttggaag caactctaca gctaagtcta aagttgtgtg      720

gagacactag cctcaacaat atgcaacgcc agcttgccct tgaagtgatc gtcaccctct      780

ctgagactgc agctgctatg ttaagaaaac ataccaatat tgttgcacag actattcctc      840

agatgttagc aatgatggtt gatttggaag aagatgagga ctgggcaaat gcagatgaac      900

tagaagatga tgattttgac agcaatgcag ttgcaggcga gagtgctcta gatcgaatgg      960

cttgcggact tggtggaaag ctcgttctgc cgatgatcaa ggaacacatt atgcaaatgc     1020

ttcaaaatcc tgactggaaa taccggcatg caggattgat ggccttatct gccattggtg     1080

aagggtgcca ccagcaaatg gaaggaattc taaatgagat cgtaaatttt gttttacttt     1140

ttctccagga tcctcatcca agagtaaggt atgcagcctg taatgccgtg ggacagatgg     1200

ctacagattt tgcacctggt ttccaaaaga aatttcatga gaaggtgatt gcagctctgc     1260

tgcagaccat ggaagaccaa ggcaatcaac gtgtgcaggc ccatgcagct gctgccctca     1320

ttaactttac tgaagactgt cccaagtcac tacttattcc atacttggat aatttggtga     1380

aacatctgca ttccattatg gtactgaagc ttcaagagct gattcagaaa ggcaccaagt     1440

tagttttgga acaagttgtg acatccattg catcagttgc cgatactgca gaagaaaaat     1500

ttgtccccta ctatgattta tttatgccat cactgaagca catcgttgag aatgcggttc     1560

aaaaagaact gagacttctg agaggaaaaa ctattgaatg cattagcctc attggtctgg     1620

ctgttgggaa ggaaaaattc atgcaggatg catcagatgt gatgcagctt ttgttaaaga     1680

cccagacaga cttcaatgat atggaagatg atgatcctca gatctcttac atgatctcag     1740

catgggccag aatgtgcaaa atccttggaa aagaatttca gcaatacctt ccagtggtta     1800

tggggccttt aatgaagacg gcttcaatta agcccgaagt agccctttta gatacccaag     1860

acatggagaa tatgagtgat gatgatggtt gggaatttgt gaaccttgga gatcagcaaa     1920

gctttggtat taaaactgca ggactagaag aaaaatcaac tgcttgccag atgttggttt     1980

gctatgctaa ggagttaaag gaaggctttg tggagtacac cgaacaggtt gtcaaactga     2040

tggtcccttt actgaaattt tatttccacg atggtgttcg agtggcagca gcggaatcca     2100

tgcctcttct cctggagtgt gcaagagtcc gtggtcctga gtatctcaca cagatgtggc     2160

attttatgtg tgatgctcta attaaggcca ttggtacaga accagattca gacgtcctct     2220

cagaaataat gcattctttt gcaaagtgca ttgaagtaat gggagatgga tgccttaata     2280

atgaacactt tgaagaactg ggaggtatat tgaaagcaaa gcttgaagaa cattttaaaa     2340

atcaagaatt acgacaagtt aaaagacaag atgaagacta tgatgaacag gtcgaagagt     2400

cactacaaga tgaggatgat aatgatgttt atattctgac caaagtgtca gatattttac     2460

actcaatatt cagtagctac aaagaaaagg tgttaccatg gtttgaacag ctgcttccat     2520

taattgtcaa cctcatttgt ccacatagac catggccaga cagacaatgg ggattatgca     2580

tctttgatga tgtcatagaa cactgtagtc cagcctcatt taaatacgca gaatatttct     2640

taagaccaat gctccaatat gtatgtgaca acagcccaga agtcaggcaa gcagctgcat     2700

atggcctggg agtcatggca cagtacggtg gagataatta tcgccctttt tgtacagaag     2760

cacttcccct gctggtaaga gttattcagt ctgcggattc taagaccaaa gaaaatgtca     2820

atgctacaga gaactgcatc tcagcagtag ggaaaatcat gaagttcaag cctgactgtg     2880

taaacgttga agaggtcctt ccacactggt tgtcttggct tccactacat gaagataaag     2940

aagaagctgt tcagactttc aattatctgt gtgacctgat tgaaagtaat catccaattg     3000

ttcttggccc aaacaatacc aatctgccca aaatatttag tataattgcg gaaggagaaa     3060

tgcacgaggc aattaaacat gaagatcctt gtgccaaacg tctggccaat gtcgttcgcc     3120

aagtacagac ttctggagga ctgtggactg agtgcatagc acagctcagt cctgagcagc     3180

aggccgccat tcaggagctc ctgaactctg cgtgaagggc cttaatgtca cccaccagaa     3240

aactaactcc aaataaacgc ttaccctttc                                      3270


<210> 2209
<211> 2949
<212> DNA
<213> Homo sapiens

<400> 2209
ggccgggata gaagccgcag cccaggcggc ggtccctccc gctgtcgccg cccgggtgta       60

gcgcatcacc cggagcccac cggccgcagg tgcctcctcc ggccccaggg ggccccggga      120

gccctgaagg gcgaagcggc agggacgcct ctcttgggcg aagaggcggc ctcaccgccc      180

cggatgcggc cggagggcgc gggaatggag ctcggaggcg gcgaggagcg cctgcctgag      240

gagagcagga gggagcactg gcagttgctg ggtaatttga agacgacggt ggagggtttg      300

gtatcaacca acagccccaa cgtctggtct aagtatggtg gcttggagcg gctttgcagg      360

gacatgcaga gcatcctcta tcacgggctt atccgtgacc aggcgtgccg ccgccagacg      420

gattactggc agttcgtgaa agacatccgg tggctcagtc cccactcagc ccttcacgtg      480

gagaagttca tcagcgtgca cgagaacgac cagagcagtg ctgatggtgc cagtgaacgt      540

gctgttgccg agctgtggct gcagcacagc ctgcagtacc actgcctctc agcccagctc      600

cggcccctgc tcggggatag acagtatatc agaaaattct acacagatgc tgccttcctg      660

ctaagtgacg ctcatgtcac ggccatgctg cagtgcctgg aagcagtgga acagaacaac      720

ccccgcctcc tggctcagat cgatgcgtcc atgtttgcca gaaagcacga gagcccgctc      780

ctggtgacaa agagccagag cctgacagcc ctgcccagtt ccacatacac ccctccaaac      840

agctatgctc agcattccta ctttgggtcc ttctctagcc tccaccaatc cgtgcccaac      900

aatggctcag agagaagatc tacttccttt ccactctctg gccctccccg gaaacctcaa      960

gaaagcagag ggcacgtctc accagcagag gatcaaacca tccaagcccc cccagtttca     1020

gtctctgcac tagccaggga ttcccctttg accccaaatg aaatgagctc cagtactctg     1080

accagcccca tagaggcatc ctgggtcagc agccagaatg attccccagg tgatgccagt     1140

gaggggcctg agtacctggc cattggcaac ttggaccccc gaggccggac tgccagctgt     1200

cagagtcaca gcagcaatgc cgagagcagc agttccaatt tgttctcctc cagcagctcc     1260

cagaagccag attctgctgc ctcttcctta ggggaccagg aaggaggtgg ggagagccag     1320

ctgtccagtg tcctccgcag gtccagcttc tcagaggggc agacactcac tgtcaccagt     1380

ggggcaaaga aaagccacat tcgctcccat tcggatacca gcattgcctc caggggagct     1440

ccagaatcct gcaatgataa ggcgaagttg agaggccctt tgccctactc tggtcaaagc     1500

agtgaagtca gcacacccag ctctctgtac atggaatatg aaggtggtcg gtacctgtgc     1560

tcaggggaag gcatgttccg aagaccatca gaaggacagt ccctcatcag ctacctctct     1620

gagcaagact tcggcagctg tgccgacctg gaaaaggaga atgcccactt cagcatctca     1680

gagtccttaa ttgctgccat cgagctaatg aagtgcaaca tgatgagcca gtgcctagag     1740

gaggaggaag tggaagagga agacagtgat agagagatcc aggagctgaa gcagaagatc     1800

cgccttcggc gccagcaaat ccgcaccaag aacctgctcc ccatgtacca ggaggctgag     1860

cacggaagct ttcgggtcac ctccagcagc tcccagttca gctcacgtga ttcggcacag     1920

ctctctgact ctggctctgc tgatgaggtt gatgaatttg aaatccaaga tggtagcgaa     1980

ggatctaacc tgactcacat atcaaagaac ggactgtcag tgtcactggc ctcgatgttc     2040

tcagatgctg acatcagaag gaacacagcc tcaagcagca aatccttcgt ttcctcccag     2100

tccttctccc actgcttcct gcactccacg tctgctgagg cggtggccat ggggctcctg     2160

aagcagtttg aggggatgca gcttccagcc gcctcggagc tggagtggct tgtcccggag     2220

catgatgccc ctcagaagct cctgcccatt cctgactcac tgcccatctc accggatgac     2280

gggcagcacg ctgacatcta caagctgcgg attcgtgttc gtggcaactt ggagtgggcc     2340

ccgccccggc ctcagataat ttttaatgtt catccagccc caacgaggaa aattgccgtg     2400

gccaagcaga attaccgctg tgcaggatgt ggcatccgga ctgaccctga ttacatcaag     2460

cgactgcggt actgtgagta cctgggcaag tacttctgcc agtgctgcca cgagaatgcc     2520

cagatggcca tccccagccg ggttctgcgc aagtgggact tcagcaagta ctacgtcagc     2580

aacttctcca aggacctgct cattaagatc tggaatgatc ctctcttcaa cgtgcaggac     2640

ataaacagtg ccctctatag gaaggtcaag ctgctcaatc aagtccggct gctgcgggtc     2700

cagctgtgtc acatgaagaa catgttcaag acttgccgac tggccaagga gcttctggat     2760

tcctttgaca cagtcccagg ccacctgaca gaggacctcc acctgtactc actgaatgac     2820

ctgactgcga ccaggaaggg ggagctgggg ccccggcttg ctgagctcac cagggcaggg     2880

gctacccatg tggagagatg catggtgaga aagtctcact gtagcatgca gctgagccct     2940

tgcttttag                                                             2949


<210> 2210
<211> 2714
<212> DNA
<213> Homo sapiens

<400> 2210
acctgctggg agctggagga ggcgcggagc gaagccggcc ctgccagcca cgcggagaag       60

cagaggcagg tgagcgcgat gcagccggcg ccgggtctgg ggctcgggga ctcctccctg      120

caccgctacc tggacggcga cttctggagc ctcaagaacg agctgcgcgg actcctcggc      180

ggcgcccgct cttccggcaa aggtatgatt taagcttgga tgaaatgaga gctttgacag      240

ttcagagagt gaagtttgcc atggacctgc ctctgttaaa acgtgcaggt caggatctgg      300

cagagaaaac aaagaatttt gtcagccgaa gccttgtcat aggagaagtc ctctccatgg      360

cggacatggc cacaggagtg aagtgcggaa taatttattg gctatttggt ggtgctatca      420

ggaatctcgg aagccctgaa catgttacta agtggtttca gccactccag gagcagaaat      480

acactgggat gtttgcaatg accgagaggg gccatgggag caacgcgaga gggatccaga      540

ccgaagccac ctttgacctc tctgcccagg agtttgtaat tgacacgccg tgtgaaaatg      600

cggagaagat gtatattgga aatgccatgt acgggaatta tgcagctgtc tttgcccagc      660

tcatcataga tggaagatct caagggcccc actgtttcat cgttcctgtc cgggatgaaa      720

acggaagctt gtacccagga gtcacagcta ttgatatgat gtacaaggag ggtctgcatg      780

gtgtggacaa tgggatatta atatttgaca aggttcggat acccagggag aacctgctgg      840

ataagtttgg ttccgtggct ccagatggac agtaccattc gcctattagg aacaagagtg      900

caagattcaa tgccatgctg gcagcactga ccccttcgag attagctgtg gctttccaag      960

ctatgggtgc catgaagctt gggttgacga tagccattcg ctatagccac agccggaggc     1020

agtttgggcc caaaaccaag gaagaggtga agatcattga gcaccaaaca cagaccctgc     1080

ggctgatgcc ccacctggcc acagccttgg ccctgacctt cgtcagcagg tatgctgggg     1140

ccctcctgga tgaggatgtc ttccagggaa aggagctggt caacagtcgc tcgctgcagg     1200

ctctggtggc ggggctgaag gcctacagca cctgggagaa catccgctgc ctgcaggact     1260

gccgcgagtg cactggaggc atgggttaca tgatggaaaa tcgaatctca ggcttaaagt     1320

gtgacacaga tgtgtttgcc acttttgaag gtgacgatgt tgttatgctt caggttgtgg     1380

ggcgggaact gctggcccaa tacaccaaac agtatgaaga aaaaccactc tttggcctgc     1440

tccaaaactg ggctgaatct gtgggggaca agctgagaac cagtttcctg gcatttaaca     1500

tggacacagt tgatgatctc gcctttctgt tgaaagcagt gaaatttcgt gaaagggttc     1560

ttcagcgggg tttggtggcc agaatttatt ataaggtaaa gaccaagaag gaggattttt     1620

tccatgcctg gaactcgtgt ctgcaccacg tggcttctct gtccctggca cacactcacc     1680

gagttacctt agagcagttc tccctagcag tgaagagctg tcctgaccaa gaggaccaga     1740

ctttgttaat gaagttttgt ctgttgtatg gaaccaagct ggtgtttcag gagcgggcct     1800

ggtatttaga acataaatac ttgactccca tggccagcac gaggatcagg aatcaggaga     1860

gatgctgaaa cacaaacagg tataagactc agtctccaca tgaagggagc tcatatccaa     1920

ggacacaaaa ccactttaaa aacataaata ctggccaggt gcagtggctc atgcctgtaa     1980

tcccagcact atgggaggct gaggcgggca gatctcctga gctcaggagt tcgacaccat     2040

cttgggcaac atggtgaaac cctgtctact aaaatacaaa aaaattagct gggcgtggtg     2100

gcatgtggct gtagtcccag ctactcggga ggctgaggca cgagaatcgc ttgagccctg     2160

gagttggagg ttgcagtgag cagagattgc gccactgtac tccagtttgg actacagagt     2220

gagactccat ctcaaaacaa aacaaaacaa caacagcaaa aaacaacaaa acaaaacaca     2280

aatactctca cagggcatgg aggttttcga atgaacttgg ccataagaat aaattcagag     2340

ttgacagaac agacgtctta ggaataaatg ccattcttat gctagacctt gaagagtaga     2400

aaattaagag atggtggccc aattgagagg ggaaaatgca gttgaaactt cagacagggt     2460

tgataaagtg aggacgatca tagacatgga gtacttagac atattaataa acaataaaga     2520

ctttacctgt ctaatggaaa acctggagaa gtcgtcagga accagactac agtggaccct     2580

ggagaacctt gaagaacatt tttccttttc aggaaaacgg aggttacaga gaaaagtata     2640

tgtaatgatg ctacagtaat gtatttctgt ataacaaatg actccaaact tacgacttaa     2700

aacaaccacc actt                                                       2714


<210> 2211
<211> 7474
<212> DNA
<213> Homo sapiens

<400> 2211
tgctcgctgc ggagccgttt tgtgccgcgg cgcgggggaa cggggacgcg gggcgggggg       60

cgcggagccg gcgggcgcag cctcagcatg gacgtgacag tctcggagct cctggagctc      120

ttcctgcaga gcccgctggt gacctgggtg aaaacttttg gcccgtttgg aagcggcagc      180

caggacaacc tgactatgta catggattta gtggacggca tctttttgaa ccaaattatg      240

ctgcaaatag atcccaggcc cacaaatcaa cgcatcaata agcacgtcaa caatgatgtg      300

aaccttcgca ttcagaattt gaccatcttg gtgagaaaca ttaagaccta ctaccaggaa      360

gttctccagc agctgattgt aatgaatttg cccaatgttt tgatgattgg cagagaccca      420

ctgtctggga agagcatgga ggaaatcaag aaggtgctgc tgctggtgct gggctgtgct      480

gtccagtgtg agaggaaaga ggagttcatt gaaagaatca aacagctgga cattgagacc      540

caggctggca tcgtggccca tatccaggag gtgactcaca accaagagaa cgtgtttgac      600

ctgcagtggc tggagctgcc cgacgtggct ccggaggagc tggaggccct gtcgaggagc      660

atggtgctcc acctgcggag gctcatcgac cagcgggacg agtgcaccga gctgatcgtg      720

gacctcactc aggaacggga ctacctgcag gcacagcatc cacccagccc catcaagtcc      780

tccagcgccg actccactcc cagccccacc agcagcctct ctagcgaaga caagcagcac      840

ctggccgtag agctggccga caccaaggcc aggctgcggc gcgtcaggca ggagctggag      900

gataagacag agcagcttgt ggacaccaga catgaggtgg accagctggt gctggaactg      960

cagaaagtta agcaggagaa catccagcta gcggcagacg cccggtctgc tcgtgcctat     1020

cgagacgagc tggattccct gcgggagaag gcgaaccgcg tggagaggct ggagctggag     1080

ctgacccgct gcaaggagaa gctgcacgac gtggacttct acaaggcccg catggaggag     1140

ctgagagaag ataatatcat tttaattgaa accaaggcca tgctggagga acagctgact     1200

gctgctcggg cccggggcga taaagtccat gagctggaaa aggagaacct gcagctgaaa     1260

tccaagcttc acgacctgga attggaccgg gacacagata agaaacgaat tgaggagctg     1320

ctggaagaaa acatggtcct tgagattgca cagaagcaga gcatgaacga atctgcccac     1380

cttggctggg agctggagca gctgtccaag aacgcagact tgtcagacgc ctccaggaag     1440

tcgtttgtgt ttgagctgaa cgaatgtgcg tccagccgca tcctgaagct ggagaaggag     1500

aatcagagcc tccagagcac catccagggg ctgcgggacg cgtccctggt gttggaggag     1560

agcggcctca agtgcgggga gctggagaag gagaaccacc agctcagcaa gaagattgaa     1620

aagttacaaa cccagctgga gagagaaaag cagagcaacc aagatctgga gaccctcagt     1680

gaggagctga tcagagagaa ggagcagctg cagagtgaca tggagaccct gaaggctgac     1740

aaagccaggc agatcaagga ccttgagcag gaaaaggacc acctcaaccg agccatgtgg     1800

tcgctgcggg agaggtcgca ggtcagcagt gaggcccgca tgaaagacgt ggagaaggag     1860

aacaaagccc tccaccagac ggtgacggag gccaatggca agctcagcca gttggagttt     1920

gagaagcggc agctgcacag ggacttggag caggccaagg agaaggggga gcgggcagag     1980

aagctggaga gggagctaca gcgactccag gaggagaacg ggaggctggc caggaaggtg     2040

acctccctgg agacagccac cgagaaagtc gaggccctgg agcatgagag ccagggcctg     2100

cagctggaga accggactct gaggaagtct ctggacacct tgcagaacgt gtccctgcag     2160

cttgagggcc tggagcgtga caacaagcag ctggacgcag agaacctgga gctgcgcagg     2220

ctggtggaga ccatgcgctt caccagcacc aagctggcac agatggagag ggagaaccag     2280

cagctggagc gtgagaagga ggagctgagg aagaacgtgg atctgctcaa ggcgctgggc     2340

aagaagtcag agcgcctgga gctcagctac cagagcgtga gcgctgagaa cctccggctg     2400

cagcagagcc tggagagcag cagccacaag acgcagacct tggagagtga gctgggcgag     2460

ctggaggctg agcgccaggc gctgcggcgg gacctggagg ccctccggct ggccaatgca     2520

cagttggagg gggccgagaa ggacaggaag gccctggagc aggaggtggc ccagctcgag     2580

aaggataaga agctgctgga gaaggaggcc aagcggctgt ggcagcaggt ggagctcaag     2640

gatgcagtct tggacgatag cactgccaaa ctgtccgccg ttgagaagga gagccgcgcg     2700

ctggacaagg agctggcccg ctgcagggac gcagccggca agctgaagga gctggagaag     2760

gacaaccggg acctcaccaa gcaagtcacc gtgcatgcaa ggacactgac aactctgagg     2820

gaggacctgg tgctcgagaa gctgaagagc cagcagctca gcagtgagct ggacaagctg     2880

agccaggaac tggagaaggt cggcctcaac agggagctgc tgttgcagga ggacgacagc     2940

ggcagtgaca caaaatacaa gattttggag ggcagaaatg aatcagcatt aaaaacaaca     3000

ctagccatga aagaagaaaa gattgtgctc ttagaagcac agatggaaga gaaagcgagc     3060

ctaaatcgcc agttagagag tgagctgcag atgctaaaga aggagtgtga gaccctcagg     3120

cagaaccagg gagaggggca gcacttgcag aactctttca agcaccctgc ggggaagaca     3180

gccgccagtc accaggggaa ggaggcctgg gggcccggcc ataaggaagc caccatggag     3240

cttctccgag tgaaggaccg ggccatcgag ctggagcgga ataatgcagc tctgcaggct     3300

gagaagcagc tgctaaagga acagctgcag cacctggaga cccagaacgt gaccttcagc     3360

agccagatct tgacactgca gaaacagagc gccttcctgc aggagcacaa caccacactg     3420

cagacccaga ccgccaagct gcaggtggag aactccacgc tgagttccca gagcgcagcg     3480

ctcaccgcgc agtacacgct gctgcagaac caccacacgg ccaaggagac ggagaacgaa     3540

agcctgcaga ggcagcagga gcaacttaca gcggcctacg aggccctgct gcaggaccac     3600

gagcacctgg gcacgctgca cgagcggcaa tcggccgagt acgaggccct catccgccag     3660

cacagctgcc taaagacact gcatcggaat ctggagctgg agcacaagga gctcggggag     3720

aggcacggtg acatgctgaa gcgcaaggcg gagctggagg agcgggagaa ggtcttgacc     3780

actgagcgag aggcgctgca gcaggagcag aggacaaacg ccctcgccat gggcgagaac     3840

cagaggctgc ggggcgagct ggacagggtc aatttcctgc accaccagct gaagggggag     3900

tacgaggagc tgcacgccca caccaaggag ctgaaaacct cactgaacaa cgcgcagctg     3960

gagctcaacc gctggcaggc ccgcttcgac gagctgaagg agcagcacca gaccatggac     4020

atctcgctga ccaagctgga caaccactgt gagctgctct cccgtctcaa ggggaacttg     4080

gaggaagaaa atcatcacct cctgagccag atccagctgt tgagccagca gaaccagatg     4140

cttctggagc agaacatgga gaacaaggag cagtaccatg aggagcagaa gcagtacata     4200

gacaaattaa atgccttacg aagacataag gaaaagctgg aagaaaaaat catggatcaa     4260

tacaagttct atgatcctcc tccaaagaag aagaaccact ggattggagc caaagcctta     4320

gtcaaactca tcaaaccaaa gaaagagggt tcgagggaac gcttaaaatc caccgtggac     4380

agccctccct ggcagctgga gtcctcagac cccgcctcgc cggcggcctc tcagccgctc     4440

agatcacagg ccgagaaccc cgacaccccc gcactgggct ccaactgtgc agaagagcgc     4500

gacgcccaca acgggtctgt ggggaaaggc cctggggatc taaaaccaaa gcgaggctcc     4560

ccacacagag gcagccttga ccgcacagat gcctccaccg atctggccat gaggtcctgg     4620

ccctcggagc tgggctcccg gacttgctca acttcagcca ccactacagc cccttccaac     4680

tccaccccca tcgcccggca cccaggccgc accaaaggct ataactcaga tgacaacctc     4740

tgtgagccat ccctggagtt tgaggtcccc aaccacaggc agtacgtgtc gcggccaagt     4800

agcttagaga gcagtagaaa cacatccagc aacagctcac ctcttaacct aaaaggctcc     4860

tccgagcagc tccatggccg gtctgagagc ttcagcagcg aagacctgat ccccagcagg     4920

gacctggcca ctttgccccg ggaagccagc acaccgggac gcaacgccct cggccgccac     4980

gagtacccct tgcctcggaa cgggcctctc ccacaggagg gtgcccagaa gaggggcaca     5040

gcccctccct acgtcggagt gcggccctgc tcggcctccc ccagcagtga gatggtcacc     5100

ttggaggagt tcctggagga gagcaaccgc agctccccca cccatgacac tcccagttgc     5160

cgggatgacc tgctgagtga ctacttccga aaggccagcg atcccccagc catcggaggc     5220

caaccaggac cacctgccaa gaaagaaggg gccaagatgc ccaccaactt tgtggccccc     5280

accgtcaaaa tggccgcccc cacctcggag gggaggccgc tgaagcccgg gcagtacgta     5340

aagccaaact tcagactgac tgaggccgag gccccaccca gcgtggcccc gagacaggcc     5400

cagcctcccc agagcctgtc tctgggcaga ccccggcagg ctccggtgcc cccagcttcc     5460

catgcacctg ccagccgcag tgcctccttg agccgggcct tcagcctggc ctcagctgac     5520

cttctccggg ccagcgggcc agaggcctgc aaacaggagt cccctcagaa gctgggggct     5580

cctgaggcct tagggggcag agagacaggc agccacaccc tgcaaagccc cgcacccccc     5640

agctcccata gcctggcccg ggagcggacc ccacttgtgg gaaaggctgg cagctcctgt     5700

cagggcccag gtccccgcag ccggccgctg gacacgaggc gcttctccct ggctccccca     5760

aaggaggaga ggctggcccc cctgcatcag tctgccacag cccccgccat tgccactgca     5820

ggtgctggtg ctgctgctgc tggcagtggc agcaactccc agctcctgca cttctcacct     5880

gctgcagccc cggctgccag gaccaagccc aaggcgcccc cacgctcagg ggaggtggcc     5940

accatcaccc ctgtccgggc agggctcagc ctctcagagg gagacggggt cccggggcag     6000

ggctgcagtg aggggcttcc ggccaagagc ccaggtcggt ctcccgattt ggctccccac     6060

ctcggccggg ccctggagga ctgcagtcga gggagcgtct caaagagcag tccggcctcc     6120

ccggagcccg gcggggatcc gcagaccgtg tggtatgagt acggctgtgt gtgactgtct     6180

cgtggttgag ctcgcaaacc tgaaaactac tgacgcgcct tccgactctc acggcctttt     6240

ctcttgcttg cctgcggtgc caggagaggg tttggaatga ggaaaggggt tcccacgcat     6300

ttctgctgtt tgttctgtga atggaaacac tgtgccaagc cccaagagga ttacgcttcc     6360

aggtgtgtaa cgtgttttct gtgtctgccg cttccagcag ctgatatctt tggaacaaat     6420

aatccacgtc agcatgggga ccaattagga tgcaatgaca aactgacttc ccccaaagca     6480

gacactactc cagtatgtcc cagtagaaca ctcatttgca atgtgttgag ctccgttaag     6540

cacacacaca ctcacacaac aggcttacga ggctcaggcc tggcgggtca gaaagcccac     6600

tccctctccc aaggccactg gatcccagga gaagcccaga ctggcgatac tacaaaggtc     6660

tccagggcct ggcagacccc agagtcaggc ctgctgttaa aaagtgagag tgctgctgtt     6720

ccattcctgg ggtcccaagc acttcccttt accccaggac ccagggcagc ctgcagggca     6780

gctggcggtg gccttggcca tttgccccca gcctccagct ggctcctgag ctctgcacca     6840

gggggtttgg ggaccacaca ggcacctgcc ttcctagatt tccctggctc acttttctgc     6900

aaacactgga tctgccaggc ctggggattg gggggcagga aagaggcccc catccagccc     6960

cctccaggcc agtgtgcaca gtgcaccgag gggtcatccg cacagagcga ggtgcaagct     7020

cgatgtgtaa cctggctgcg gcacccgaca tccccggtct cggggtgttg atttatttct     7080

gaataacttt ttgggtatag aaaccaattt tttttaatat atgacatgta tatgtacaca     7140

ctcatgtgaa atatgtatac tttgggggga tctatttatg ttccagtggg agtcactctc     7200

ttctgtcggg aatcttatct gctgctttgt gtctttggtc agattcctga caatttagtt     7260

tcctgttgta aaggtgcttt tcctggggtg aactaaacct attgattttt tttttttaag     7320

attttttttt ccttttgatt taatatactg agaaagaaat gggagacttt tgaatgttaa     7380

caagatccat tttaggagtg tttggggttg tgtattaaat agccattcat tctggaactc     7440

aaggacagga ctgtaataaa atggaatgga accg                                 7474


<210> 2212
<211> 8215
<212> DNA
<213> Homo sapiens

<400> 2212
ccgagccggg agccgagcgc gctgggcgcg gccgtcccgc tgccgccgcc aagcccggag       60

tgcgccagcg gccatggttc ccgcggcggc gccgggcgcc tgagccccgg gacgcaagcg      120

ctggaggcgg gctgccggct gtgcgggcgc tccggagaga ccgacagaag gtgagcactg      180

tgggctatgg gatggatgag gtggagcagg accagcatga ggcccgactc aaggagctgt      240

ttgacagttt tgacacgacg ggcacagggt ccctggggca ggaggaactc accgaccttt      300

gccacatgtt gagcttggag gaggtggccc cagtgctgca gcagacatta cttcaggaca      360

acctcttggg cagggtacat tttgaccaat ttaaagaagc attaatactc atcttgtcca      420

gaactctgtc aaatgaagaa cactttcaag aaccagactg ctcactagaa gctcagccca      480

aatatgttag aggtgggaag cgttacggac gaaggtcctt gcccgagttc caagagtccg      540

tggaggagtt tcctgaagtg acggtgattg agccactgga tgaagaagcg cggccttcac      600

acatcccagc cggtgactgc agtgagcact ggaagacgca acgcagtgag gagtatgaag      660

cggaaggcca gttaaggttt tggaacccag atgacttgaa tgcttcacag agtggatctt      720

cccctcccca agactggata gaagagaaac tgcaagaagt ttgtgaagat ttggggatca      780

cccgtgatgg tcacctgaac cggaagaagc tggtctccat ctgtgagcag tatggtttac      840

agaatgtgga tggagagatg ctcgaggaag tattccataa tcttgatcct gacggtacaa      900

tgagtgtaga agattttttc tatggtttgt ttaaaaatgg aaaatctctt acaccatcag      960

catctactcc atatagacaa ctaaaaaggc acctttccat gcagtctttc gatgagagtg     1020

gacgacgtac cacaacctca tcagcaatga caagtaccat tggctttcgg gtcttctcct     1080

gcctggatga tgggatgggc catgcatctg tggagagaat actggacacc tggcaggaag     1140

agggcattga gaacagccag gagatcctga aggccttgga tttcagcctc gatggaaaca     1200

tcaatttgac agaattaaca ctggcccttg aaaatgaact tttggttacc aagaacagca     1260

ttcaccaggc ggctctggcc agctttaagg ctgaaatccg gcatttgttg gaacgagttg     1320

atcaggtggt cagagaaaaa gagaagctac ggtcagatct ggacaaggcc gagaagctca     1380

agtctttaat ggcctcggag gtggatgatc accatgcggc catagagcgg cggaatgagt     1440

acaacctcag gaaactggat gaagagtaca aggagcgaat agcagcctta aaaaatgaac     1500

tccgaaaaga gagagagcag atcctgcagc aggcaggcaa gcagcgttta gaacttgaac     1560

aggaaattga aaaggcaaaa acagaagaga actatatccg ggaccgcctt gccctctctt     1620

taaaggaaaa cagtcgtctg gaaaatgagc ttctagaaaa tgcagagaag ttggcagaat     1680

atgagaatct gacaaacaaa cttcagagaa atttggaaaa tgtgttagca gaaaagtttg     1740

gtgacctcga tcctagcagt gctgagttct tcctgcaaga agagagactg acacagatga     1800

gaaatgaata tgagcggcag tgcagggtac tacaagacca agtagatgaa ctccagtctg     1860

agctggaaga atatcgtgca caaggcagag tgctcaggct tccgttgaag aactcaccgt     1920

cagaagaagt tgaggctaac agcggtggca ttgagcccga acacgggctc ggttctgaag     1980

aatgcaatcc attgaatatg agcattgagg cagagctggt cattgaacag atgaaagaac     2040

aacatcacag ggacatatgt tgcctcagac tggagctcga agataaagtg cgccattatg     2100

aaaagcagct ggacgaaacc gtggtcagct gcaagaaggc acaggagaac atgaagcaaa     2160

ggcatgagaa cgaaacgcac accttagaaa aacaaataag tgaccttaaa aatgaaattg     2220

ctgaacttca ggggcaagca gcagtgctca aggaggcaca tcatgaggcc acttgcaggc     2280

atgaggagga gaaaaaacaa ctgcaagtga agcttgagga ggaaaagact cacctgcagg     2340

agaagctgag gctgcaacat gagatggagc tcaaggctag actgacacag gctcaagcaa     2400

gctttgagcg ggagagggaa ggccttcaga gtagcgcctg gacagaagag aaggtgagag     2460

gcttgactca ggaactagag cagtttcacc aggagcagct gacaagcctg gtggagaaac     2520

acactcttga gaaagaggag ttaagaaaag agctcttgga aaagcaccaa agggagcttc     2580

aggagggaag atatgaatct gaaaagcttc aacaggaaaa ttctattttg agaaatgaaa     2640

ttactacttt aaatgaagaa gatagcattt ctaacctgaa attagggaca ttaaatggat     2700

ctcaggaaga aatgtggcaa aaaacggaaa ctgtaaaaca agaaaatgct gcagttcaga     2760

agatggttga aaatttaaag aaacagattt cagaattaaa aatcaaaaac caacaattgg     2820

atttggaaaa tacagaactt agccaaaaga actctcaaaa ccaggaaaaa ctgcaagaac     2880

ttaatcaacg tctaacagaa atgctatgcc agaaggaaaa agagccagga aacagtgcat     2940

tggaggaacg ggaacaagag aagtttaatc tgaaagaaga actggaacgt tgtaaagtgc     3000

agtcctccac tttagtgtct tctctggagg cggagctctc tgaagttaaa atacagaccc     3060

atattgtgca acaggaaaac caccttctca aagatgaact ggagaaaatg aaacagctgc     3120

acagatgtcc cgatctctct gacttccagc aaaaaatctc tagtgttcta agctacaacg     3180

aaaaactgct gaaagaaaag gaagctctga gtgaggaatt aaatagctgt gtcgataagt     3240

tggcaaaatc aagtctttta gagcatagaa ttgcgacgat gaagcaggaa cagaaatcct     3300

gggaacatca gagtgcgagc ttaaagtcac agctggtggc ttctcaggaa aaggttcaga     3360

atttagaaga caccgtgcag aatgtaaacc tgcaaatgtc ccggatgaaa tctgacctac     3420

gagtgactca gcaggaaaag gaggctttaa aacaagaagt gatgtcttta cataagcaac     3480

ttcagaatgc tggtggcaag agctgggccc cagagatagc tactcatcca tcagggctcc     3540

ataaccagca gaaaaggctg tcctgggaca agttggatca tctgatgaat gaggaacagc     3600

agctgctttg gcaagagaat gagaggctcc agaccatggt acagaacacc aaagccgaac     3660

tcacgcactc ccgggagaag gtccgtcagt tggaatccaa tcttcttccc aagcaccaaa     3720

aacatctaaa cccatcaggt accatgaatc ccacagagca agaaaaattg agcttaaaga     3780

gagagtgtga tcagtttcag aaagaacaat ctcctgctaa caggaaggtc agtcagatga     3840

attcccttga acaagaatta gaaacaattc atttggaaaa tgaaggcctg aaaaagaaac     3900

aagtaaaact ggatgagcag ctcatggaga actcagtggt tggaagtagc agagaagggt     3960

gcagttctct gcctgagata gtgtgtgaag atgcagcacc tgaggtccac tgcgacgcct     4020

agcccgtccc ctcatgcttg ggatttgcag ctgctccagc agcaagcctg tccgatggtg     4080

cccagggagc agtttctgca gcttcaacgc cagctgctgc aggcagaaag gataaaccag     4140

cacctgcagg aggaacttga aaacaggacc tccgaaacca acacaccaca gggaaaccag     4200

gaacaactgg taactgtcat ggaggaacga atgatagaag ttgaacagaa actgaaacta     4260

gtgaaaaggc ttcttcaaga gaaagtgaat cagctcaaag aacaactctg caagaacact     4320

aaggcagacg caatggtgaa ggacttgtat gttgaaaatg cccagttgtt gaaagctctg     4380

gaagtgactg aacagcgaca gaaaacagca gagaagaaaa attacctcct ggaggagaag     4440

attgccagcc tcagtaatat agttaggaat ctgacaccag cgccattgac ttctacacct     4500

cctttgaggt catagccaaa ccaaagggta cactcatatt tgtgcacttt actgaaatag     4560

atgaacattt cagtaggttc tcaacttaaa attaagccta acctaaaact gccagcaaca     4620

caactggagt ttccatttat cataattagt ttttctaaat agacccttat gggagtttga     4680

aaataaatac tcacatattt cactacttaa attattccca agatttgaat ttattttaaa     4740

attttaatag ccaccaagaa tgtggacata tgaaaattca agaacctaaa aaataccagt     4800

tttgaatgag tttttgtggt tttggttttt tttttaatta ttacaaatct atgtgtaaaa     4860

tctagatatt tgaagtttga gatctgatga gaatggttgt tataaacttt attttaaaac     4920

caaatttagg tgttcttaca tatttaaata ctggaaagtc attataatag ttttggttct     4980

ttgaattggt agacaattag tagagtataa ttggttagga ggcagggctt attaagtggt     5040

tattaaccgc tgacatcaga caaacccaaa tctgtagaat tctaaccttc taacacctgt     5100

gacagtatta ccactcttct tgtattatag atttagaact gatttactca attgcactct     5160

taactaatgt taaaagctta cttgctttaa acagcctttt cttctttctc ttaaaagttt     5220

catttgggga gctggtcttc taagaaacgg ataaagccac ataattaaag cagttgaact     5280

atagggaaag cactgaacaa accactttgg agtaaatagc tactcttaga aaagagggat     5340

aagcagacca tgtaggtttt ctgtctctca aatcttagag ttcataaatt tacttgaggt     5400

tgcctcaaga actcagggaa caatactgta aactgtcttc ctgaactact gtagggcctc     5460

tctaagaatt tgaaatgtat aaaccatgtg acctcattta tttgtcttat atatttacag     5520

ccatactaga atttttattt ctacgttttt agtaaattta atattctggg ggaaaaaagg     5580

ccttgatttt agggttaaaa acctgactta tagaagagtt tatttaatat aggtcaaaat     5640

tttctgtgtt tcttattcct tctatacctc aaatctgatt ctaagaattt cttactgtga     5700

taatcattgg catgccacct gaggtcaagg agtgccaaat aggactttcc actcatgctc     5760

aagatcaaaa ctttatagaa cagtcaacat tttagattcg gtaacctttt ttttcttcca     5820

attataatct ctgctagcca cttccgccag cagttggtgg aagacttact aggtgcaggg     5880

cactttccaa gttcatcaca acaacctgct tgttttcatg agacaataat ccgaaaagtt     5940

cgctttgata tattcctgga gggccaagcc catctattta caaaaggtga acagcaaaat     6000

caagcactgc tttatgggca ggaacacaag agaaagcaaa ctgcccaaga agtcatcatg     6060

tcagaaactc aatctcaaca aaataatttc catcagggaa cttcagggtt tcttgggggc     6120

ttatgagtct caccggtcaa cccaggaggc ctcactacaa gagccttgac aaggcactgt     6180

tttttgtggg actgggagtt cacactgatg aagcaaacct ttgaattttt gcacagctct     6240

tgtcagaaag ccctgagttc cccctggata aagagttaat tttaatcctt ccctataatt     6300

atacttcaaa atatttgaca tctgctatta tgccttcttt agatctttct tctgtggtgc     6360

agacatttct agtaagtgtt tgactacttg tatggcatta gctttcacag aaaattgttt     6420

cacttaaaac tgtggattgg cctaggctaa ggacaaaaat aaactaagta cctgtagtgt     6480

atttatgtga tatgtgtcaa gttactcaaa gttattgctg ttggaactga acaataatat     6540

ttcccagata gctggcctta gcatgtgatc acggttgttg tatttttaat ttttgtcttt     6600

tacagtatga gaggtgtagg ttaatttgtt tatttcctat aaatttgtat ttatgtgtat     6660

ataaaatgta caatgaatgt aaatatgact ttctggaaag tttagactac atttagaatc     6720

tctattcaaa atcaaaatgc tgctcaaatg aatttaacca acatctaggt gcttaatttc     6780

tcattttatc ccacttatga gattgggaaa aagatcaata tgagaaatac catacagata     6840

ccttaaatgt atgcatttgt gcaacaattt ttgagaaggt gagtggcaat ttataattta     6900

gttggcaatt tataatagaa cttatagctt ttaaaagacc ttttaaagac attaaatgta     6960

aacttaaaaa tgtttagatc ttgtttcaaa ctttacaata gcattcttca aaatattaag     7020

ttatatattt tataggcatt tagttgctta ttaaaagcac tgattttcaa actttttgat     7080

ttaagaacaa ttatttaaga tcgtctcaga agatgggatc ttcgtttcaa gaaaagggaa     7140

tcaagtttgc ctttgagata atacgttaca ctaagaaaag gaaaatgtgg atagtaaaac     7200

ccacctctct catcctattg tactctcttc tgctttttag aagcctgcac ttaagcttag     7260

atttgtgaag ggagagtaga aggggagaag tagaaccaca gtgttttatt tatttttcta     7320

aaactcttac taaatccaga ttttttaaac tgttttaaat gtgaattctt cccagaaatt     7380

tcaatgcatt gcatatttag ccttcggcat atttttcatg aatagatcat gaagtcatag     7440

gcttccaagg cataggaaga gatcttgcag gtctagtatt ttaataatgc actattaccc     7500

agggcagata ttatgagaaa ctgtttcttc tctaagggtt tatggcagac tttgcttttt     7560

taacatgtga gaaatgaatt ttttattttg tgatttatgt gatttctttt gctgagtgaa     7620

ggaaaggaga aattgttgct attgtcagca tcttaaaggt atttccagtc aaggcaaggc     7680

taagtgcttt gtgatagtat taagcaagtc atgttttgaa tggattacct gtagtgactc     7740

attggaatga tataattata caagtaatgc caaaaaccaa gtcaaagcct aattaaccaa     7800

agcactcatt taaaaatcat catgtttgga cctatctgga cctctcagca ctgtaaaata     7860

gttttggttt tgtggcatat gaatagctgt ttaacaaatc aaagttagct ttttgcttct     7920

cagctttttt gggcaataca agttaagttc ttaatgggga gacattatca tggcatgact     7980

taagggaaca ttggtttgtg aaggaaaaac agattatcta aagccatctc tatgtttctg     8040

ttcagataaa gattaatgag ttctgtgttt atatcagctt tgtatatttc atcttagcca     8100

ttctatccta gaaagatttt aatgtgagct taagatgtaa ataaataatt ttgcaaacat     8160

gccttttgtt ttctatatac cctgaccttt taataaagtt tcagtgtatt tatca          8215


<210> 2213
<211> 3643
<212> DNA
<213> Homo sapiens

<400> 2213
gcgttgttgg tttcgggttg tcaggcagcg cgcgaggcgg cgggcagcta gcagctggcg       60

gacgcgaccc ggaggcggtg ggggtgcggc tgagccatgc ccggtggcgc ggcctgagcc      120

cctccacctg ctgcaatcat gaaggacagc ggggactcca aggaccagca actcatggtg      180

gcgcttcggg tccggcccat cagcgtggca gagctggagg aaggagctac cctcatcgcc      240

cataaagtgg atgagcagat ggtggttctc atggacccaa tggaggatcc cgacgacatc      300

ctgcgggcgc atcgctcccg ggagaagtcc tacctgttcg acgtggcctt tgacttcacc      360

gccacccagg agatggtgta tcaggccacc accaagagcc tcatcgaggg cgtcatctca      420

ggctacaatg ccactgtctt tgcctatggc cccacaggct gtgggaaaac ctacaccatg      480

ctgggcacag accaggagcc tggcatctat gttcagaccc tcaacgacct cttccgtgcc      540

atcgaggaga ccagcaatga catggagtat gaggtctcca tgtcctacct ggagatctac      600

aatgagatga tccgggacct gctgaacccc tccctgggct acctggagct gcgggaggac      660

tctaaggggg tgatccaggt ggccggcatc accgaagtct ccaccatcaa tgccaaggag      720

atcatgcagc tgctgatgaa ggggaaccgg cagaggaccc aggagcccac ggccgccaac      780

cagacgtcct cccgctccca cgcggtactg caggtgaccg tgcgccagcg cagccgggtc      840

aagaacatct tgcaggaggt gcggcagggc cgcctgttca tgatcgacct ggctggctca      900

gagcgcgcct cgcagacaca gaatcgtggg cagcgtatga aggagggggc ccacatcaac      960

cgctcactgc tggcactggg caactgcatc aacgccctga gcgacaaggg tagcaacaag     1020

tacatcaact atcgcgacag caagctcacc cggctcctga aggactctct gggaggaaac     1080

agccgcacag tgatgatcgc tcacatcagt cctgcgagca gtgccttcga ggagtcccgg     1140

aacaccctga cctacgccgg ccgggccaag aacattaaga ctagggtgaa gcagaacctc     1200

ctgaacgtct cctaccacat cgcccagtac accagcatca tcgctgacct gcggggcgag     1260

atccagcgac tcaagcgcaa gattgatgag cagactgggc ggggccaggc ccggggccgg     1320

caggatcggg gtgacatccg ccacatccaa gctgaggtcc agctgcacag cgggcagggt     1380

gagaaggctg gcatgggaca gcttcgggag cagctcgcca gcgccttcca ggagcagatg     1440

gatgtgcgga ggcgcctgct ggagctggag aaccgcgcca tggaggtcca gattgacacc     1500

tcccgacacc tgctcaccat cgccggctgg aagcatgaga agtcccgccg ggccctcaaa     1560

tggcgggagg agcagcgaaa ggagtgctac gctaaggacg acagcgagaa ggactcagac     1620

acaggtgatg accaaccaga catcctggag ccacccgagg tggccgcagc ccgggagagc     1680

attgcagccc tggtggacga gcagaagcaa ctgcgcaagc agaagctggc gctggagcag     1740

cgctgccggg agctgcgcgc gcggggccgg cgcctggagg agacgctgcc gcggcgcatc     1800

ggctccgagg agcagcgcga ggtgctcagc ctgctgtgcc gcgtgcacga gctcgaggtg     1860

gagaacaccg agatgcagtc gcacgcgctg ctccgcgacg gtgcgctccg ccaccgccac     1920

gaggccgtgc gccgcctgga gcagcaccgc agtctctgcg acgagattat ccagggccag     1980

cggcagatca tcgacgacta caacctggcc gtcccgcagc gcctggaaga gctctacgaa     2040

gtgtacctgc gggagctgga ggagggcagc ctggagcagg ccaccatcat ggaccaagtg     2100

gcctccaggg ccctgcagga cagctccttg cccaaaatta ccccagcagg aacctcactg     2160

accccagatt ctgacctgga gagtgtgaag acattgagct ctgatgccca gcacctgcag     2220

aacagcgccc tccctcccct cagcacagag agtgaaggcc accacgtgtt caaggctggt     2280

actggggcct ggcaggcaaa aagctcctct gtgcccaccc cacctcccat ccagctcggc     2340

agcctggtga cgcaggaggc cccggctcag gacagcctgg gcagctggat caactcttcc     2400

cctgacagca gtgagaacct gtcggagatc cccttgtccc acaaagagag gaaggagatc     2460

ctgactggca ccaagtgcat ctgggtgaag gccgcccggc ggcgctcgcg ggccctggga     2520

accgaggggc gacacctgct ggcacccgcg acagagcgca gcagcctgtc cctgcactca     2580

ctgagcgagg gcgacgatgc gcggccacca ggcccactgg cctgcaagcg gccgcccagc     2640

cccacactac agcatgctgc cagtgaggac aacctgtcca gcagcacggg cgaggccccg     2700

tcccgggcag tcggacatca tggggacggc cccaggccct ggctgcgtgg ccagaagaaa     2760

agcctgggca agaaaaggga ggagtcgctg gaggcaaaga gaaggaagcg gaggtcccga     2820

tccttcgagg tcaccgggca agggctctcc caccccaaga cacacctcct ggggccccat     2880

caggcggagc gcatctcgga ccacaggatg ccagtgtgca ggcacccagc ccctggtatc     2940

cggcatctgg gaaaggtcac gctacctttg gccaaagtca aactccctcc aagccagaac     3000

acgggcccgg gggactcctc acccctggct gttcccccca acccaggtgg tggttctcga     3060

cgggctaccc gtgggccccg cctgccccac ggcacaagca cccatggcaa agatggatgc     3120

tcccggcata actgaggggc cctgcctgga actggctctc tcacctccca agactgaatg     3180

gggtctagca gggcatggga ggtggaggct gggcagatgg agatgaccag gaagtaagct     3240

caggatctca gcaggccagg gctcctgaga cccaggaact ggggtctctg cccaaccctc     3300

ccatgctttc agtgccactg gggaaaagag gtgaggccag gggacatggc caggacggct     3360

gggctccctg gcttcccagc cctggacaga atgctgttgc caaaacctgc acagccctga     3420

ggccagcctc ggccttggta acggaggaaa gcagctgaca gtgagacggg gctcctggcc     3480

cacgtgtggg gcacgggcat cctggatggt tggggaggcg ccgacaggca cttcacgtat     3540

tacaattggg gatgtgggtg agggagggaa tctggttttg ttacttggca gtggtttttt     3600

ctcacccttc ctttttaaca ataaaatccc atttgggtct tga                       3643


<210> 2214
<211> 1777
<212> DNA
<213> Homo sapiens

<400> 2214
ctactccgcc gagcctacgt gacacgacgt caagtggcaa tggcggcgga cgagggctgt       60

gcccccggcc cgccccgtta ggagccgcga gtaaggcgag tgtccaacgc cgagctggct      120

gacagagccc ggccgcggcc tccgcgggcc caggggcctc caggccccgt gaccaccgga      180

ccgagcaccc tggaacggcc ccagcttggc ctcgggacag tccgcgcgct caccgactcc      240

ctggtgaacg ccgcttggcc gccgccgccg ccgcaggacc cacgagaagc ggaaaccggc      300

gcaaggaccc ggtccccccg gcgccgaatg tagtaagaaa acaaaaactg atgaccaaga      360

gaatgtgtca gccgatgcac cgagtccagc ccaggaaaat ggagagaagg gagaattcca      420

caagttggct gatgccaaga tatttttgag cgactgcctg gcatgtgaca gctgtatgac      480

tgcagaggaa ggagtccaac tttcccagca aaatgccaag gacttcttcc gcgttctgaa      540

ccttaacaag aaatgtgata cctcaaagca caaagtgctg gtagtgtctg tgtgtcctca      600

atctttgcct tattttgctg ctaaattcaa cctcagtgta actgatgcat ccagaagact      660

ctgtggtttc ctcaaaagtc ttggggtgca ctatgtattt gatacgacga tagctgcgga      720

ttttagtatc ctggagagtc aaaaagaatt cgtgcgtcgc tatcgccagc acagtgagga      780

ggaacgcacc ctgcccatgc tgacctctgc ctgtcctggc tgggtccgat acgccgagcg      840

ggtgctgggt cgccccatca ctgcccacct ctgcaccgcc aagtcccccc agcaggtcat      900

gggctctttg gtgaaggatt atttcgccag acagcagaac ctgtctccag agaagatttt      960

ccacgtcatt gtggcccctt gttatgacaa gaagctggag gctcttcagg aaagccttcc     1020

ccctgctttg catggctccc ggggcgctga ctgcgtgtta acatcaggtg aaattgctca     1080

aataatggag caaggtgacc tctcagtgag agatgctgcc gtcgacactc tgtttggaga     1140

cttgaaggag gacaaagtga cgcgtcatga tggagccagc tcagacgggc acctggcaca     1200

catcttcaga catgcggcca aggagctgtt caacgaggat gtggaggagg tcacttaccg     1260

agccctgaga aacaaagact tccaagaggt cacccttgag aagaacggag aggtggtgtt     1320

acgctttgct gcagcctatg gctttcgaaa catccagaac atgatcctga agcttaagaa     1380

gggcaagttc ccattccact ttgtggaggt cctcgcctgt gctggaggat gcttaaatgg     1440

cagaggccaa gcccagactc cagacggaca tgcggataag gccctgctgc ggcagatgga     1500

aggcatttac gctgacatcc ctgtgcggcg tccggagtcc agtgcacacg tgcaggagct     1560

gtaccaggag tggctggagg ggatcaactc ccccaaggcc cgagaggtgc tgcataccac     1620

gtaccagagc caggagcgtg gcacacacag cctggacatc aagtggtgaa gtcaggccag     1680

ggccttccag ctgctcttgg ggccagagcc aagagcctct cagtagaggg aggggctgcc     1740

ctgagtggag tattaaagac acttaagaaa accgctc                              1777


<210> 2215
<211> 3888
<212> DNA
<213> Homo sapiens

<400> 2215
atgaaggttg caggaggact tgaacttgga gctgctgctc tgctctcagc atcaccacgt       60

gctcttgtca ctctttccac aggtcctact tgctctatat taccaaagaa tccacttttc      120

ccccaaaacc tgagctctca gccttgtatc aagatggaag gagacaaatc gctcaccttt      180

tccagctacg ggctgcaatg gtgtctctat gagctagaca aggaagaatt tcagacattc      240

aaggaattac taaagaagaa atcttcagaa tcgaccacat gctctattcc acagtttgaa      300

atcgagaatg ccaacgtgga atgtctggca ctcctcttgc atgagtatta tggagcatcg      360

ctggcctggg ctacgtccat tagcatcttt gaaaacatga acctgcgaac cctctcggag      420

aaggcacggg atgacatgaa aagacattca ccagaagatc ctgaagcaac gatgactgac      480

caaggaccaa gcaaggaaaa agtgccagga atttcacaag ctgtgcaaca agatagtgcc      540

acagctgcag agacaaaaga acaagaaatt tcacaagcta tggaacaaga aggtgccaca      600

gcagcagaga cagaagaaca agaaatttca caagctatgg aacaagaagg tgccacagca      660

gcagagacag aagaacaagg acatggaggt gacacatggg actacaagag tcacgtgatg      720

accaaattcg ctgaggagga ggatgtacgt cgtagttttg aaaacactgc tgctgactgg      780

ccggaaatgc aaacgttggc tggtgctttt gattcagacc ggtggggctt ccggcctcgc      840

acggtggttc tgcacggaaa gtcaggaatt gggaaatcgg ctctagccag aaggatcgtg      900

ctgtgctggg cgcaaggtgg actctaccag ggaatgttct cctacgtctt cttcctcccc      960

gttagagaga tgcagcggaa gaaggagagc agtgtcacag agttcatctc cagggagtgg     1020

ccagactccc aggctccggt gacggagatc atgtcccgac cagaaaggct gttgttcatc     1080

attgacggtt tcgatgacct gggctctgtc ctcaacaatg acacaaagct ctgcaaagac     1140

tgggctgaga agcagcctcc gttcaccctc atacgcagtc tgctgaggaa ggtcctgctc     1200

cctgagtcct tcctgatcgt caccgtcaga gacgtgggca cagagaagct caagtcagag     1260

gtcgtgtctc cccgttacct gttagttaga ggaatctccg gggaacaaag aatccacttg     1320

ctccttgagc gcgggattgg tgagcatcag aagacacaag ggttgcgtgc gatcatgaac     1380

aaccgtgagc tgctcgacca gtgccaggtg cccgccgtgg gctctctcat ctgcgtggcc     1440

ctgcagctgc aggacgtggt gggggagagc gtcgccccct tcaaccaaac gctcacaggc     1500

ctgcacgccg cttttgtgtt tcatcagctc acccctcgag gcgtggtccg gcgctgtctc     1560

aatctggagg aaagagttgt cctgaagcgc ttctgccgta tggctgtgga gggagtgtgg     1620

aataggaagt cagtgtttga cggtgacgac ctcatggttc aaggactcgg ggagtctgag     1680

ctccgtgctc tgtttcacat gaacatcctt ctcccagaca gccactgtga ggagtactac     1740

accttcttcc acctcagtct ccaggacttc tgtgccgcct tgtactacgt gttagagggc     1800

ctggaaatcg agccagctct ctgccctctg tacgttgaga agacaaagag gtccatggag     1860

cttaaacagg caggcttcca tatccactcg ctttggatga agcgtttctt gtttggcctc     1920

gtgagcgaag acgtaaggag gccactggag gtcctgctgg gctgtcccgt tcccctgggg     1980

gtgaagcaga agcttctgca ctgggtctct ctgttgggtc agcagcctaa tgccaccacc     2040

ccaggagaca ccctggacgc cttccactgt cttttcgaga ctcaagacaa agagtttgtt     2100

cgcttggcat taaacagctt ccaagaagtg tggcttccga ttaaccagaa cctggacttg     2160

atagcatctt ccttctgcct ccagcactgt ccgtatttgc ggaaaattcg ggtggatgtc     2220

aaagggatct tcccaagaga tgagtccgct gaggcatgtc ctgtggtccc tctatggatg     2280

cgggataaga ccctcattga ggagcagtgg gaagatttct gctccatgct tggcacccac     2340

ccacacctgc ggcagctgga cctgggcagc agcatcctga cagagcgggc catgaagacc     2400

ctgtgtgcca agctgaggca tcccacctgc aagatacaga ccctgatgtt tagaaatgca     2460

cagattaccc ctggtgtgca gcacctctgg agaatcgtca tggccaaccg taacctaaga     2520

tccctcaact tgggaggcac ccacctgaag gaagaggatg taaggatggc gtgtgaagcc     2580

ttaaaacacc caaaatgttt gttggagtct ttgaggctgg attgctgtgg attgacccat     2640

gcctgttacc tgaagatctc ccaaatcctt acgacctccc ccagcctgaa atctctgagc     2700

ctggcaggaa acaaggtgac agaccaggga gtaatgcctc tcagtgatgc cttgagagtc     2760

tcccagtgcg ccctgcagaa gctgatactg gaggactgtg gcatcacagc cacgggttgc     2820

cagagtctgg cctcagccct cgtcagcaac cggagcttga cacacctgtg cctatccaac     2880

aacagcctgg ggaacgaagg tgtaaatcta ctgtgtcgat ccatgaggct tccccactgt     2940

agtctgcaga ggctgatgct gaatcagtgc cacctggaca cggctggctg tggttttctt     3000

gcacttgcgc ttatgggtaa ctcatggctg acgcacctga gccttagcat gaaccctgtg     3060

gaagacaatg gcgtgaagct tctgtgcgag gtcatgagag aaccatcttg tcatctccag     3120

gacctggagt tggtaaagtg tcatctcacc gccgcgtgct gtgagagtct gtcctgtgtg     3180

atctcgagga gcagacacct gaagagcctg gatctcacgg acaatgccct gggtgacggt     3240

ggggttgctg cgctgtgcga gggactgaag caaaagaaca gtgttctggc gagactcggg     3300

ttgaaggcat gtggactgac ttctgattgc tgtgaggcac tctccttggc cctttcctgc     3360

aaccggcatc tgaccagtct aaacctggtg cagaataact tcagtcccaa aggaatgatg     3420

aagctgtgtt cggcctttgc ctgtcccacg tctaacttac agataattgg gctgtggaaa     3480

tggcagtacc ctgtgcaaat aaggaagctg ctggaggaag tgcagctact caagccccga     3540

gtcgtaattg acggtagttg gcattctttt gatgaagatg accggtactg gtggaaaaac     3600

tgaagatacg gaaacctgcc ccactcacac ccatctgatg gaggaacttt aaacgctgtt     3660

ttctcagagc aagctatgca cctgggagtt ccttctcaaa gatggagaat gatttctgat     3720

tctcacaaag ccctcaatgg tagtgattct tctgtgttca ctctacgttg gttactggat     3780

ttgaaggcta gagaccttca agtcatagga ctcagtatct gtgaaatgtc cgtcatatct     3840

cagagcatat agagggaatt aaataaacac aaagcatttg gaaaagtt                  3888


<210> 2216
<211> 3608
<212> DNA
<213> Homo sapiens

<400> 2216
ggttccgctg aggcgtggta ggaagtggct gccgtcaatc actcggggag actccaaaca       60

gtgagcctag agctggagac tagcgttaac cggcggggcg gccggtttta tgaatgaagc      120

tatggctaca gattccccaa gaagacccag tcgttgtact ggtggagttg tggttcgccc      180

ccaggctgtc acagagcagt cctacatgga aagtgttgtg acttttctgc aggatgttgt      240

gccacaggct tacagtggaa cacctctaac agaagaaaag gagaaaatag tctgggtcag      300

atttgaaaat gcagatttaa atgatacatc aagaaatctg gaatttcatg aaatacatag      360

tactgggaat gaaccgcctt tgttgattat gattggctac agtgatggaa tgcaggtctg      420

gagcatccct atcagtggtg aagcacaaga gctcttctct gttcgacatg gcccaattcg      480

agcggctaga atcttgcctg ctccacagtt tggtgctcaa aaatgtgata actttgctga      540

aaaaagaccc ctccttggtg tttgtaagag cattggatct tctggcacaa gcccaccgta      600

ctgttgtgtg gatctgtatt cacttcgtac tggggagatg gtcaagtcca ttcaatttaa      660

gacacctatt tatgatctcc attgcaataa acggatcctt gtcgtagtct tgcaggagaa      720

aattgctgcc tttgatagct gtactttcac gaagaaattc tttgttacaa gctgctatcc      780

atgtccaggg ccaaacatga atcctattgc tcttgggagc cgctggcttg cttatgcaga      840

aaacaagttg attcgatgtc atcagtcccg tggtggagcc tgtggagaca acattcagtc      900

ttatactgcc acagtcatta gtgctgctaa aacattgaaa agtggcctga caatggtagg      960

gaaagtggtg actcagctga caggcacact gccttcaggt gtgacagaag atgatgttgc     1020

catccacagt aattcacggc ggagtccttt ggtcccaggc atcatcacag ttattgacac     1080

cgaaaccgtt ggagagggcc aggtgcttgt gagtgaggat tctgacagtg atggcattgt     1140

ggcccacttc cctgcccatg agaagccagt gtgctgcatg gcttttaata caagtggaat     1200

gcttctagtc acaacagaca cccttggcca tgactttcat gtcttccaaa ttctgactca     1260

tccttggtcc tcatcacaat gtgctgtcca ccatctgtat actcttcaca ggggagaaac     1320

tgaagccaaa gtacaggaca tctgcttcag ccatgactgt cgctgggttg tggtcagtac     1380

tctccggggt acttcccacg ttttccccat caacccttat ggtggccagc cttgtgttcg     1440

tacacatatg tcaccacgag tagtgaatcg catgagccgt ttccagaaaa gtgctggact     1500

ggaagagatt gaacaagaac tgacgtctaa gcaaggaggt cgctgtagcc ctgttccagg     1560

tctatcaagc agcccttctg ggtcaccctt gcatgggaaa ctgaacagcc aagactccta     1620

taacaatttt accaacaaca accctggcaa ccctcggctc tctcctcttc ccagcttgat     1680

ggtagtgatg cctcttgcac aaatcaagca gccaatgaca ttggggacca tcaccaaacg     1740

aaccgggcct tatctctttg gagcggggtg tttttccata aaagccccat gcaaagttaa     1800

acctcctcca caaatttcac ccagcaaatc gatgggcgga gaattttgtg tggctgctat     1860

cttcggaaca tccaggtcat ggtttgcaaa taatgcaggt ctgaaaagag aaaaagatca     1920

gtccaaacaa gttgtagttg agtccctgta cattatcagt tgctatggca ccttagtgga     1980

acacatgatg gagccgcgac ccctcagcac tgcacccaag attagtgacg acacaccact     2040

ggaaatgatg acatcgcctc gagccagctg gactctggtt agaacccctc aatggaatga     2100

attgcagcca ccgtttaatg caaaccaccc tctgctcctc gctgcagatg cagtacagta     2160

ttatcagttc ctgcttgctg gcctggttcc ccctggaagt cctgggccca ttactcgaca     2220

tgggtcttac gacagtttag cttctgacca tagtggacag gaagatgaag aatggctttc     2280

ccaggttgaa attgtaacac acactggacc ccatagacgt ctgtggatgg gtccacagtt     2340

ccagttcaaa accatccatc cctcaggcca aaccacagtt atctcatcca gttcatctgt     2400

gttgcagtct catggtccga gtgacacgcc acagcctctt ttggattttg atacagatga     2460

tcttgatctc aacagtctca ggatccagcc agtccgctct gaccccgtca gcatgccagg     2520

gtcatcccgt ccagtctctg atcgaagggg agtttccaca gtgattgatg ctgcctcagg     2580

tacctttgac aggagcgtga ccctgctgga ggtgtgcggg agctggcctg agggcttcgg     2640

gctgcggcac atgtcctcca tggagcacac ggaggagggc ctccgggagc gacttgccga     2700

cgccatggcc gagtcaccta gccgggacgt cgtgggatcc ggaacagaac ttcagcgaga     2760

gggaagcatc gagactctga gtaacagctc aggctccacc agcggcagca taccaagaaa     2820

ctttgatggc taccgatctc cgctgcccac caatgagagc cagcccctca gcctcttccc     2880

gactggcttc ccgtaggtac cagcaacctg cttctgactg gccagccccc tcccctgctg     2940

gaggagggga gaagccccgc tctggtccta cccttcagtc tctgctcttc cttcatcaac     3000

caccttcccc aagcttagtg acagcagccg cccatcctac ctggatggag aagagaccct     3060

tctccaagca cctcagcgca cttgccctct gccacacctg tcggtggagg ctgtggccag     3120

gagagactgt agaagctcgg tccctgtgta tgtttgcata tgacatcctg cattggatcc     3180

gcttttgtat tttttaacca tacccacggt ggggcgggtg gggggagcct ggaacagtga     3240

ccagatctgg gggcctgagt ggggacagag ttgatcgtcc acctggccat tttgaccctg     3300

agtggacagt cacagcctca gctcatgtct ggctgtgaca cacactgccc ccagcttccc     3360

ttggtcagcc ccactccagc acggggtgaa cggaggccca gagtactagg gaaggaggaa     3420

gggaggacat gcctcttctt cctcctttct ttccccatct gttcatggga agagtttgtc     3480

tttcttatct ttaagcccct ttaccctggt cctgtactga tcagtgaagg aaaccgtggt     3540

tactgaggcc ctgttgaaaa gtgcacgtct tgtccaataa atcacgctgc agttggtgtc     3600

catccctg                                                              3608


<210> 2217
<211> 1074
<212> DNA
<213> Homo sapiens

<400> 2217
cttcctggaa acccacccag aacctccacc ctctgacacc atggtcaact cctgttgtgg       60

ctctgtgtgc tctgaccagg gctgtggcct agagaactgc tgccgtccca gctactgcca      120

gaccacctgc tgcaggacca cctgctgccg ccccagctgc tgtgtgtcca gctgctgcag      180

accccagtgc tgccagacca cctgctgcag gaccacctgc tgccacccca gctgctgtgt      240

gtccagctgc tgcagacccc agtgctgcca gtctgtgtgc tgccagccca cctgctgcag      300

accccaatgc tgccagacta cctgctgtag gaccacctgc tgccgcccca gctgctgcag      360

gccccagtgc tgccagtctg tgtgctgcca gcccacctgc tgctgcccca gctactgtgt      420

gtccagctgc tgcagacccc agtgctgcca gaccacctgc tgcagaacca cctgctgccg      480

ccccagctgc tgtgtgtcca ggtgctacag gccccattgt ggccagtctc tatgctgcta      540

gcccatctgc tggcaaacca cctgctacag gaccacctgc tgccacccca gctattgcat      600

ttccagctgc tgccagcctt cctgcagtat ctctagcagc agtagctcct cctgctgtgg      660

cttcagctgc tgcaggctct cctgctgcat ctccagttgc tgccgcccca actgctgcca      720

gaccatgtgc tgccgcccaa cctgctctag tgcttcttgc tgctgaggct gtcatctgga      780

ctcaccagat tctcatcaac cagcattctt gatgtagctc atctatgagc tgagttatgg      840

gaagctagtt ggaaaacttc agttccaacc aattcttaga ttgaatctgg cctccaaata      900

tatgctcccc ccacatttta cctctctacc aaatgaacat aagttgtaat ttgctctgaa      960

atctgtcaac tatcttaatt gaaatatttg ctctctgcca taatttctca tatggagcta     1020

ttccatttta aacaaatatt tatctaaata aatcttaaat aaattttcag gcat           1074


<210> 2218
<211> 2478
<212> DNA
<213> Homo sapiens

<400> 2218
ttcactcgct gaagtcatct gggagacagt gccaaatgtt ccactccaga gtcttggcct       60

ctaggaggca ggaacagcag gcctggccag cccaaaggac tctctatcca ggatgtaaat      120

gagcacactg ctggcccatg cgcctcgggg ctgtagaggg cagcctcaga ggcactgggc      180

attcctggca ccatggatga cgctgctgtc ctcaagcgac gaggctacct cctggggata      240

aatttaggag agggctccta tgcaaaagta aaatctgctt actctgagcg cctgaagttc      300

aatgtggcga tcaagatcat cgaccgcaag aaggcccccg cagacttctt ggagaaattc      360

cttccccggg aaattgagat tctggccatg ttaaaccact gctccatcat taagacctac      420

gagatctttg agacatcaca tggcaaggtc tacatcgtca tggagctcgc ggtccagggc      480

gacctcctcg agttaatcaa aacccgggga gccctgcatg aggacgaagc tcgcaagaag      540

ttccaccagc tttccttggc catcaagtac tgccacgacc tggacgtcgt ccaccgggac      600

ctcaagtgtg acaaccttct ccttgacaag gacttcaaca tcaagctgtc cgacttcagc      660

ttctccaagc gctgcctgcg ggatgacagt ggtcgaatgg cattaagcaa gaccttctgt      720

gggtcaccag cgtatgcggc cccagaggtg ctgcagggca ttccctacca gcccaaggtg      780

tacgacatct ggagcctagg cgtgatcctc tacatcatgg tctgcggctc catgccctac      840

gacgactcca acatcaagaa gatgctgcgt atccagaagg agcaccgcgt caacttccca      900

cgctccaagc acctgacagg cgagtgcaag gacctcatct accacatgct gcagcccgac      960

gtcaaccggc ggctccacat cgacgagatc ctcagccact gctggatgca gcccaaggca     1020

cggggatctc cctctgtggc catcaacaag gagggggaga gttcccgggg aactgaaccc     1080

ttgtggaccc ccgaacctgg ctctgacaag aagtctgcca ccaagctgga gcctgaggga     1140

gaggcacagc cccaggcaca gcctgagaca aaacccgagg ggacagcaat gcaaatgtcc     1200

aggcagtcgg agatcctggg tttccccagc aagccgtcga ctatggagac agaggaaggg     1260

cccccccaac agcctccaga gacgcgggcc cagtgagctt cttgcggccc agggaatgag     1320

atggagctca cggcttaaag cccaagctct gaagaagtca agggtggagc cagagaagga     1380

aggcagtccc agatgagcct ctattttcat cagcttcttc tctctcccct tgaacttggt     1440

aacccacatg gttctcccgt ggcccctagg tggatgaggc caaagtcaaa tccaaggctg     1500

agacagtcgt gcgactccta ctcccccaga gcgtgacccg gagcaggtgc tggacacaga     1560

gcctgtctca gcagagggtc cccactggcc gcaacggctc agtgacagca agagcaggaa     1620

gagcagcagg aaggcaccgc tgtccacctt gggcaccatt tatcctcctt tcatcgtccc     1680

cggggcagtt gcgtgaccct gctgggaggc cagaccgggc cagactgagg gtcaggggac     1740

caggctgggt tgggggttgg gtggggctgg acggggacga ggcgcggaga ggcggcggga     1800

aagagcttcg gctgggccac gggctcgcgg gcactctcgg cggcagcctc gggggctccg     1860

actccagctc tgggcaagat ccataaactt ttaaagaagc ctcaaaacat acttttaaag     1920

cattaagctt taaagtgcta gaaatcttgt gccccatatg tgcttctttc agtattatcc     1980

tagatcctca ggagtagcat ggcaactgga gaaaatggga ggaaagacaa gaagaaatag     2040

aagctgattt aacatcaagt ttattcagtt ttgatttttc ttatctctac tggctttctc     2100

ctgttcaaac cttgcagcga taatatttgg aaaagagcac ttggaaatta tattcctgtt     2160

tttaactctt tatatttaat cattctcctt gtaattgatt ttgtagctaa tttactcccc     2220

agcaccccca gaagaaaatt ttacaaagga aaatgtttta tttttatttt ttccttatca     2280

actttttatt taaatgctaa tatccaatta atggacaaac gaatcagcta atactggaaa     2340

caatgtaaca atagtgaaaa gcatgaactt ttgatttcta tagaccgaat ttgactctgc     2400

tactaaatga tcttgggcaa gttggttaat ctatatgtct cagtttcttt atctataaaa     2460

tgagaataat acaacttc                                                   2478


<210> 2219
<211> 646
<212> DNA
<213> Homo sapiens

<400> 2219
acaaaccaac tcaccactcc tgacaccatg agtcactacg gcagctacta cggaggcctg       60

ggctacagct gtggaggctt cggtggcctg ggctatggct atggctgtgg atgtggcagc      120

ttctgcagac ggggttctgg ctgtggctat ggaggctacg gatatggctc tggctttgga      180

agctacggat atggctctgg ctttggaggc tacggatatg gctctggctt tggaggctat      240

ggatatggct gctgccgccc atcgtacaat ggaggatacg gattctctgg cttttattaa      300

atgaattgct gaaattggaa gcagaggaga aacctccaaa tgtgtttggt cctgtcccgt      360

gctttcattc caaaaatcca ttctattgcc ttcagcatca atggagagat atttagctat      420

gttaaatctt taaaatagat ttaagctgct tctgtgaata tttgttgtct ttttactttc      480

ggagtccgtc acctgaaatc atattcatgt ataactactc taggttgttc ttctaaattt      540

gctttatttt tcttaccacc attaccttga tgttatctat caagatccta gcaaaaactt      600

gtattttgct tttatctaat aaatgaagta aagtataaat atttta                     646


<210> 2220
<211> 704
<212> DNA
<213> Homo sapiens

<400> 2220
ttaaaactca gaatcttccc aggtacactc agctgaactc acatcttccc gtcaacatgt       60

cctacaactg ttgctctaga aacttctcct cctgctccca cgggggttac ttgcactacc      120

caggctcctc ctgtggctct tcctacccca gcaacctggt ctacagcact gacctctgct      180

ctcccagcac ctgccagctg ggttcctctc tctatagggg ctgtcaggag acctgctgga      240

ggcccaacag ctgtcagaca ttgtgtgttg agtccagccc ctgccacacc tcctgctact      300

accccaggac tcacatgctc tgcaattctt gcctgactat gcatgttggg tctcggggtt      360

ttggatccaa tagctgctgc tccctgagct gtggatccag gagctgctcc tcactgggct      420

gtggatccaa tggcttcaga tatctgaatt atagaatcca tacctcccct tcccagagtt      480

atagatccag attctgccat ccaatctatt ttccacctag aaggtggttc cattcatctt      540

gttatcagcc attctgtaga tctggtttct actgactaat gtggtgactg gtaaaactca      600

tttgagaaat gcatattctt tagtaaggtc atctgttaat ttcttccttt gagaagtatt      660

ctaatattat tgatcaccag gtcttcctta ctttccagcc ctca                       704


<210> 2221
<211> 1554
<212> DNA
<213> Homo sapiens

<400> 2221
atgtctggca gttgctcttc taggaaatgc ttctccgtgc cagccacctc tctctgctcc       60

actgaggtga gctgtggagg ccccatctgc ctgcccagtt cctgccagag ccagacatgg      120

cagctggtga cttgtcaaga cagctgtgga tcatccagct gtgggccaca gtgccgtcag      180

ccctcctgtc ctgtgagtag ctgtgcccaa cccctgtgct gtgatcctgt catttgtgag      240

ccttcttgct ccgtgagcag cggctgccaa cccgtgtgct gtgaggccac cacctgtgag      300

ccttcttgct ctgtgagcaa ctgctaccaa cctgtgtgct tcgaggccac catctgtgag      360

ccttcttgct cagtgagcaa ctgctgccaa cctgtgtgct ttgaggccac cgtttgtgag      420

ccttcttgtt ccgtgagcag ctgtgctcaa cctgtgtgct gtgagcctgc tatttgtgag      480

ccttcttgct ccgtgagcag ctgctgccag cctgtaggct ctgaagccac ttcctgccaa      540

ccagtcctct gtgtgcccac ttcctgccag cctgtcctct gcaaatccag ctgctgccag      600

ccagttgtct gtgagcccag ctgctgttca gctgtctgca ccctgcctag ttcctgccaa      660

cctgtggtct gtgagccttc ctgctgtcag ccggtgtgcc cgacacctac ctgctctgtg      720

accagtagct gccaggctgt ctgctgtgac cccagccctt gtgagccaag ttgctcagag      780

tctagcatct gccagccagc tacgtgtgtg gctctggtct gtgagccagt ttgcctccgc      840

cctgtctgct gtgttcagag ctcgtgcgag ccaccttctg tccccagcac ttgccaagag      900

ccttcttgtt gtgtctccag tatctgccaa cccatctgct ctgagcccag cccctgctca      960

ccagctgtct gtgtgtccag tccatgccaa cctacttgct atgtagtcaa gcgctgtcct     1020

tctgtctgcc ctgagccagt ttcctgccca tctacctcct gccgacctct ttcctgcagt     1080

ccagggtctt ctgcatctgc catctgccga ccaacttgtc ctaggacttt ctacataccc     1140

agttccagca aacggccttg cagtgctacg atttcctacc gcccggtctc ccgtccgatc     1200

tgccgcccaa tctgctctgg actcctcacc tataggcagc catacatgac atccatctcc     1260

taccgtcctg cctgctatcg cccatgctac tccatcctgc gccgcccagc ctgtgtcact     1320

tcctactctt gccgcccagt ctacttccgc ccatcttgca ctgagtctga ctcttgcaaa     1380

cgggattgca aaaaatccac ttccagccaa ctggattgtg ttgacacaac cccctgcaag     1440

gtggatgtct cagaagaggc tccctgccag cccactgaag ccaaacccat cagcccaacc     1500

acccgtgagg ccgcagcagc tcagcctgct gccagcaagc ctgccaactg ctaa           1554


<210> 2222
<211> 1026
<212> DNA
<213> Homo sapiens

<400> 2222
atggcagacg gctgttgtcc tggaaacacc acagccattc cagctgtgcc caccatcacc       60

acatacccag ttaaaggtgg atttcgacat gctctctgtt tgcctagttc ctgccacagc      120

agaatgtggc aactggtcac atgccaagaa agctgtcagc catccattgg tgccccaagt      180

ggctgtgatc ctgcttcgtg tcaacctacc cgccttccag caacgtcttg tgtgggtttt      240

gtttgccaac ctatgtgctc ccacgcagcc tgctatcagt ctggcactgg tcagtctcct      300

tgtctggtta gctcatgtca gccatcctgc tcggaatcta cttgttgtca ggaaaagtgc      360

tgcgatgcca gtccctgcca gcaaagctcc tgccaggaat ctgtctgcat gtctggatca      420

tgtcaggcag cttgtggcca atcagtctgc tgtgatgctg gatcctgcca gccatcctgc      480

tctgaagtga cctcctgtcc ggaaacttct tgcctaccaa ccatctgtac agctagtcca      540

tgccaaccaa cttggtgcca aggaagttca tgtcaacccg tcagtggtga aggccagccc      600

tgtaaatcaa cttattatca acccatctgc tatattttca agccttgcca atcagccctc      660

tacatgcctg ttccctgcca gccatcgact tgtgtgttca gttcttgcaa tactacttgc      720

tgtgtgcctt cccattgcca gccacctcac tgccaactgg ttccttccac atgcttcatc      780

taccagccag tggctaactg ccaggcccct tgttccacaa agaactgttg caaaccagct      840

tcttgtgaca ctgtgatttc tggccaacca acttgtgatg gacccccttc ctataaccag      900

agtggctgca aatcagcttg ctgtgtgact ggtttaggca catcacccag tagtggctcc      960

aattgcttgc cgacttcatg ccaacccagc tgtgagtcca gcttctgcaa ggcaacactt     1020

tgttaa                                                                1026


<210> 2223
<211> 941
<212> DNA
<213> Homo sapiens

<400> 2223
atggtcagct cctgctgtgg ctctgtctgc tctgaccaga gctgtggtca aggtctcggc       60

caggagagct gctgccgccc cagctgctgc cagaccacct gctgcaggac cacctgctgc      120

cgccccagct gctgcatttc cagttgctgc aggccttcct gctgtatctc cagctgctgc      180

aaacccagct gctgcaggac cacctgctgc cgccccagct gctgcatttc cagttgctgc      240

aggccttcct gctgtatctc cagctgctgc aaacccagct gctgcaggac cacctgctgc      300

cgccccagct gctgcatttc tagttgctgc aggccttcct gctgtatctc tagctgttgc      360

aaacccagct gctgccagac cacctgctgc cgccccagct gctgtatctc cagctgctac      420

aggccccagt gctgccagcc ctcctgctgc cgcccggctt gctgcatttc tagttgctgt      480

catcccagct gctgtgtgtc cagctgccgc tgccctttca gctgcccgac cacctgctgt      540

agaacaacct gcttccaccc catctgctgc ggcagttctt gctgctgagt gaagctgctc      600

tggatttgtg caccttcttg ctctcaacct tcagttcagg cacagagtat ctattcagag      660

aacatgtgga cttcctgatg tcgtgaaaac agaggcatgg actgatttgg aaaatatttt      720

attagtatgt attctctttt atagaagttt ttattcctat tgaatctgaa tttacagtca      780

aattccacat cacatgtttt agaattcttt attctaattc aatatacata aatcttcaaa      840

tggtatcctt ctagatgttt cttcctaatg ttttctgtgg tatcaatttt catgtggaat      900

tgtttgatgt tcctcaataa aacttcatag tgttcaaaag c                          941


<210> 2224
<211> 1174
<212> DNA
<213> Homo sapiens

<400> 2224
ctcctagaaa cccaactaga tccttcaccc tctgacacca tggtaaactc ctgttgtggc       60

tccgtgtgct ctcaccaagg ctgtggccga gacctctgcc aggagacctg ctgccgcccc      120

agctgctgtg agaccacctg ctgcaggacc acctactgtc gccccagctg ctgtgtgtcc      180

agctgctgca ggccccagtg ctgccagtct gtgtgctgcc agcccacctg ctgccgcccc      240

agatgctgca tctccagctg ctgtcgcccc agctgctgtg tgtccagctg ctgcaagccc      300

cagtgctgcc agtctatgtg ctgccagccc acttgctgcc gccccagatg ctgcatctcc      360

agctgctgtc gccccagctg ctgtgtgtcc agctgctgca gaccccagtg ctgccagtct      420

gtgtgctgcc agcccacctg ctgccacccc agctgcagca tctccagctg ctgccgcccc      480

tcttgctgtg aatccagctg ctgccgcccc tgctgctgcc tgcgtccagt ctgtggccga      540

gtctcctgcc acaccacttg ctatcgccca acctgtgtca tctccagctg cccccgcccc      600

ttgtgctgtg cctcctcttg ctgctgagcc cactgccctg gctcatctct cccttcactg      660

caggcccaca gttgtagacc attcttctgt gctgactatt aggacacatg gagtgggatt      720

gatgtcattc agcagggtgg acttcatgtt tccaatgagc ccatcaccat cccactgact      780

ctgtgagaac attctggttc attttaaact ccctcccttg ctttctttct cttccagtca      840

tggcaccaaa tatgaaataa tttgtaatcc actagctaag aaattattcc aatcctctaa      900

attcctcatt ttttaaatcg ttttgagcct acagaatatc cttcccagtg aggtacacat      960

tatctccatt tcaaacatat tatttgtctg tcagcctttc agtcattctt ttctcttgga     1020

aaggtaggag gctgcccctc ccatgctctc ctgctttctc cctgttctct ctttgtctct     1080

gtttgttcaa gtttgccaga atttttctat tttattggtt ctttatcttt attgtgttca     1140

caaaatatat tgtattaaac ttttcattta gaaa                                 1174


<210> 2225
<211> 1157
<212> DNA
<213> Homo sapiens

<400> 2225
aaacccaaga acttcactct cttggaagcc cacccagatc ctccccgttc tgacaccatg       60

gtcagctcct gttgtggctc cgtgtgctct gaccagggct gcggccaaga cctctgtcag      120

gagacctgct gccgccccag ctgctgtgag accacctgct gcaggaccac ctgctgccgc      180

cccagctgtt gtgtatccag ctgctgcagg ccccagtgct gccagtctgt gtgctgccaa      240

cccacttgtt cccgccccag ctgctgtcag accacctgtt gcaggaccac ctgctaccgc      300

cccagctgtt gtgtgtccag ctgctgcagg ccccagtgct gccagcctgc gtgctgccaa      360

cccacttgct gtcgccccag ctgctgtgag acgacctgct gccaccctag gtgctgcatc      420

tccagctgct gtcgccccag ctgctgtgtg tccagctgct gcaagcccca gtgctgccag      480

tctgtgtgct gccagcccaa ctgctgccgc cccagctgca gcatctccag ctgctgccgc      540

ccctcttgct gtgaatccag ctgctgccgc ccctgctgct gcgtgcgtcc agtctgtggc      600

cgagtctcct gccacaccac ttgctatcgc ccaacctgtg tcatctccag ctgcccccgc      660

cccttgtgct gtgcctcctc ttgctgctga gcccactgcc ctggcttatc tcccccttca      720

ccactggccc acagatgtag acccttctac tgtgctgacc attaggatac aggaagtggg      780

gttgatgtca ttcaatagaa tggaactcat gtttccaatg agcccatcac catttcactg      840

actctttgag aacattctga ttcattttaa actccctccc ttgctttctt tttcttccgg      900

tggtggcacc aaatgtgaat taatttgtaa tccactagct agaaattatt ccaatcctct      960

aatttcctca ttttctttat cactttgagg tacagatctt cttctcagtg aggcagacat     1020

tatctgcagg accagttttg tcactgaggt tgcaccctca gatccagccg cccagttata     1080

ttctgtgttt ctcctagtgt gaatttctta tgctttgttg catctctgct ttttaataaa     1140

atttctgtac ataagaa                                                    1157


<210> 2226
<211> 850
<212> DNA
<213> Homo sapiens

<400> 2226
ctcctctcaa cagcccaacc cacaccagcc tcagacacca ccatgaccgg ctcctgctgc       60

ggctccacct tgtcctccct gagctacggg ggaggctgct gccagccctg ctgctgccgc      120

gacccctgct gctgccgccc cgtgacctgc cagaccaccg tgtgccgccc cgtgacctgc      180

gtgccccgct gcacgcgccc catctgcgag ccctgccgcc gcccggtgtg ctgcgacccc      240

tgctccctgc aggaaggctg ctgccgcccc atcacctgct gcccctcgtc gtgcacggct      300

gtggtgtgca ggccctgctg ctgggccacc acctgctgcc agcctgtgtc tgtgcagtcc      360

ccctgctgcc ggcctccctg cggccagccg accccttgca gcaccacctg caggacctcc      420

tcctgctgag accccacctc tcctctcaac gcacgaaaca ttcccaggtg cacagaagct      480

tgtgcagact cttctacccc ttctggatca gatgagagac tccacctttg cagcctagct      540

gatcctcaag cacgaattca acaataacat cctatctatt tccccacata attatgcagc      600

taatcctggc cctctctgac aatcttgaga aaaattccag ctttcatcat tcgaattcct      660

ggcttgaaaa aaaaaacgag taaataaaaa tcaaagctcc tcttgaatag aactctgtcc      720

cactgactca tcaccctttt ttctactgtt tcaaggttct cagatgagat ttttttcttc      780

caggataata ctatttgtat gctgtatttt tgcactgtaa aaaaaaataa aattatattt      840

ctggggaagc                                                             850


<210> 2227
<211> 776
<212> DNA
<213> Homo sapiens

<400> 2227
catccagctc ctctccacag cccaacccac accagcctca gacaccacca tgaccggctc       60

ctgctgcggc tccaccttct cctccctgag ctacggggga ggctgctgcc agccctgctg      120

ctgccgcgac ccctgctgct gccgccccgt gacctgccag accaccgtgt gccgccccgt      180

gacctgcgtg ccccgctgca cgcgccccat ctgcgagccc tgccgccgcc cggtgtgctg      240

cgacccctgc tccctgcagg aaggctgctg ccgccccatc acctgctgcc cctcgtcgtg      300

cacggctgtg gtgtgcaggc cctgctgctg ggccaccacc tgctgccagc ctgtgtctgt      360

gcagtccccc tgctgccggc ccccctgcgg ccagccgacc ccttgcagca ccacctgcag      420

gacctcctcc tgctgagcca ccacctgctg ccagcctgtg tctgtgcagt ccccctgcgg      480

ccagccgacc ccttgcagca ccacctgcag gacctcctcc tgctgagcag tgcactgact      540

gcccggaacg cgtaactcac cttctgaaaa agtcacactc ccatttctct actttaacaa      600

acctcctgcc ctgagcccac aaaaccccac atcaaccaag cagggaaccg agcactgggc      660

tcatctatta agacctgggc cattctgaag tctgtaaaag aagcaatttc cttcttctta      720

agatttcgtg gcatgtttat tttctaataa atatctgttc tttggccttg caaaaa          776


<210> 2228
<211> 700
<212> DNA
<213> Homo sapiens

<400> 2228
caatcaaacc cataaatacc acagactcta atagccatgg attgctgtgc ctctcgaggc       60

tgcagtgtcc ccaccgggcc tgccaccacc atctgctcct ctgacaaatc ctgccgctgt      120

ggagtctgcc tgcccagcac ctgcccacac acagtttggt tactggagcc cacctgctgt      180

gacaactgtc ccccaccctg ccacattcct cagccctgcg tgcccacctg cttcctgctc      240

aactcctgcc agccaactcc aggcctggag accctcaacc tcaccacctt cactcagccc      300

tgctgtgagc cctgcctccc aagaggctgc taatggatgg ctactttgct cagtgcctga      360

gattgaaaaa gtcaacatag aagctttagc attcacctat ctcagtacct acaactaatg      420

tactctgctt tagaaattgg aacaaggatg gtactaccac aatcaccccc tgcaaaaaaa      480

aagagaccaa gaaactttca atgaccattc agctataacc aactgcagtt tgaatcagtg      540

gatgcctata gcttcctgaa gctgttcgat tccttcatat taaagtgtct ctttctgtgg      600

gtggtttggg aattctgttt tcagtcttgg gtggtatctt tctgaaaatt aaggaagttc      660

ttcatgatta tcctaataaa ttttacatct ctggcatagc                            700


<210> 2229
<211> 692
<212> DNA
<213> Homo sapiens

<400> 2229
aagaaactga aagctaacca gacgcccatt gccatggatt gctgtgcctc tcgcagctgc       60

agtgtcccca ctgggcctgc caccaccatc tgctcctccg acaaatcctg ccgctgtgga      120

gtctgcctgc ccagcacctg cccacacaca gtttggttac tggagcccat ctgctgtgac      180

aactgtcccc caccctgcca cattcctcag ccctgcgtgc ccacctgctt cctgctcaac      240

tcctgccagc caactccggg cctggagacc ctcaacctca ccaccttcac tcagccctgc      300

tgtgagccct gcctcccaag aggctgctga tggatggcta ctttgctcag tgcccgacaa      360

cgaagaatcc agaagctgtc ccttcagtat tcacttgcct cagtagtttg ccagatgtta      420

aggtagacca gatgacccag atatgaagaa cttacctttg gttttaatgg gggaaaaaaa      480

gaaaagtatt ttttatggtt atttagctga aaaaccattt ggttcctgtg ggcaggtgaa      540

tgagttttat tagcaaaata ctgtttcaat ctttaagacc tcagattaca tgttcttgat      600

catattgctt cctggctctt gtttcttgta ctgggtattt tcatagaaga aaatttcttg      660

gtgggttttc caataaacta tatttctctg gc                                    692


<210> 2230
<211> 591
<212> DNA
<213> Homo sapiens

<400> 2230
agacttctct caactcaaca aaaacccacc tcccattgcc atgtattgct gtgctctccg       60

ctcctgcagc gtccccaccg gccctgccac caccttctgc tcatttgata aaagctgccg      120

ctgtggagtc tgcctaccca gcacctgccc acatgagatc agcctccttc agcccatctg      180

ctgtgacacc tgccccccac cctgctgcaa gcctgatacc tatgtgccaa cttgctggct      240

gctcaacaac tgtcacccga ctcccggact gagtgggatc aacctgacca cctatgttca      300

gcctggctgt gagagtccct gtgagccccg ctgttaacca gccgagtctg cacaggttcc      360

gtgaggtggc tgcccaatgt cctctgcacc atctgggctt cagcactcac tactgcctac      420

atcaaggcta aggccatccc aatccccggg gccaagtctt gatgaatctt cttaattatt      480

tgcacatttg ggtaccattg gagacctccc ttctgtcttt taggctattt catcactctt      540

tgagaaataa ccattttgac catttgttaa taaactttat tctggcttag c               591


<210> 2231
<211> 588
<212> DNA
<213> Homo sapiens

<400> 2231
cactgccctc tgcctcgacc ttatccagcc acacgccacc atgtgccaca ccagctgctc       60

ctcgggctgc cagccagcct gctgcgcgcc cagcccctgc caggcatcct gttacatccc      120

cgtgggctgc cagtcctccg tgtgcgtgcc cgtgagcttc aagccagccg tgtgtgtgcc      180

cgtgagatgc cagtcctctg tgtgcgtgcc cgtgagctgc aggcccgtcg tgtatgcggc      240

tccctcctgc cagtcctctg ggtgctgcca gccttcctgc accagcgtcc tctgcagacc      300

catctcctgc agcacccctt cctgctgctg agcatgaatc tccagacccg ctgctcccag      360

tgcagatgag gccacacctg tacactccct ggatgagtcc tcagttggtc ttctgcacat      420

ggtgcaggtg aaaagcatgc tcagtgaacc ctctgaattc tggatcgaga atataataga      480

atgatctgga gccctggctg aacttgccta tccccccagg gaagtctggg gtcccagagt      540

cattctctga ccccatgaga gtcaaataaa ccagctttcc ccatgcaa                   588


<210> 2232
<211> 447
<212> DNA
<213> Homo sapiens

<400> 2232
agaccagccc tgtcctctgc gccccccacc tgtccacact ccatcatgtg ccacaccagc       60

cactcttcgg gctgcccaat ggcctgccct ggctccccgt gctgtgtccc cagcacctgc      120

tacccacccg agggctatgg gacctcctgc tgctgctcag ccccctgtgt ggctctgctg      180

tgccggcccc tgtgtggggt atccacctgc tgccagccag cctgctgtgt gcccagcccc      240

tgccaggtgg cctgctgtgt gcctgtgagc tgcaagcctg ttttgtgtgt ggcttccttc      300

tgcccaacct ctgggtgctg ccagcccttc tgccccaccc tggtctatag acctgtcacc      360

tggagcaccc ccactggctg ctgagcaggt ggcctcctat gaccctcgta ggtgcgaggt      420

cagaagccag caggctctct gaactcc                                          447


<210> 2233
<211> 971
<212> DNA
<213> Homo sapiens

<400> 2233
tcactcactc acgtctcccc cagctcacct cctccccacc ccagcatggc cacgtctacc       60

atgtccgtct gctccagcgc ttactctgac tcctggcagg tggacgcctg cccagagagc      120

tgctgtgagc ccccctgctg cgccaccagc tgctgcgccc cggccccctg cctgaccctg      180

gtctgcaccc cagtgagctg tgtgtccagc ccctgctgcc aggcggcctg tgagcccagc      240

ccctgccagt caggctgcac cagctcctgc acgccctcgt gctgccagca gtctagctgc      300

cagccagctt gctgcacatc ctccccctgc cagcaggcct gctgcgtgcc tgtctgctgc      360

aagccagtct gctgtgtgcc cgtctgctgc aagcctgtct gctgcaagcc catctgctgt      420

gtgcccgtct gctctggggc ttcctcttca tgctgccagc agtctagccg ccagccggct      480

tgctgcacca cctcctgctg cagaccctcc tcctccgtgt ccctcctctg ccgccccgtg      540

tgcaggtcca cctgctgtgt gcccatcccc tcctgctgtg cccctgcctc cacctgccag      600

cccagctgct gccgcccggc ctcctgcgtg tccctcctct gccgccccac gtgctcccgc      660

ctctcttccg cgtgctgcgg cctctcctca ggccagaagt ccagctgctg acgggcaggt      720

cccgtttctc cagagttgtt ccagggccat ctctgacttc cgaaaatcct tgcagccctg      780

agccctgtct gagtctcctc tgcccatagc cactgcacct ccagccagca atgctgagct      840

ttcatgccga ttccctccag gcatgcatct ctcccacacc ctcatctcca tgctggccag      900

ccggtggtca ctgtgtcctg ccccatgtga gtgatcagtc tgtcaacaaa taaagtcacc      960

aatgtgccct c                                                           971


<210> 2234
<211> 1149
<212> DNA
<213> Homo sapiens

<400> 2234
tcactcactc acacacctcc cccagctcac ctcctcccca ctccagcatg gccgcctcca       60

ccatgtccat ctgctccagc gcctgcacca actcctggca ggtggacgac tgcccagaga      120

gctgctgtga gctcccctgc ggcaccccca gctgctgtgc cccagccccc tgcctgaccc      180

tggtctgcac cccagtgagc tgtgtgtcca gcccctgctg ccaggcggcc tgtgagccca      240

gcgcctgcca atcaggctgc accagctcct gcacgccctc gtgctgccag cagtctagct      300

gccagccggc ttgctgcacc tcctccccct gccagcaggc ctgctgcgtg cccgtctgct      360

gcaagcctgt gtgctgtgtg cccgtctgct gtggggcttc ttcatgctgc cagcagtcta      420

gctgccagcc agcttgctgt gcctcttcct cctgccagca gtcctgccgt gtgcctgtct      480

gctgcaaagc tgtgtgctgc gtgcccacct gctctgagtc atcctcttca tgctgccagc      540

agtctagctg ccagccggct tgctgcacct cctccccgtg tcagcagtcc tgctgtgtgt      600

ccgtctgctg caagcctgtc tgctgcaagt ccatctgctg tgtacctgtt tgctctgggg      660

cttcctctcc gtgctgccag cagtctagct gccagccagc ttgctgcacc tcctcctgct      720

gcagaccctc ctcctctgtg tccctcctct gccgccccgt gtgctcccgc ccagcctcct      780

gcagcttttc ctcaggccaa aagtctagct gctgatggcc atgtccccca gggccagccg      840

ggctcaggcc ccacctccct gccagtcctt ggacctccca gcccacccag cctcagcaca      900

gctcagcaca gaaggagcag ccccagccac agccgcccag ccccggggtc tcagatgctc      960

actggctcct ctctgacctc ccgccgggcg ggcgagccct ggcttctcct cacggtgctt     1020

cctggctgca gaccacaacc ctccgctggt cgctggtcgc tggttgggga tgggccctcc     1080

tgacctgggt ctcaccccca ggagcgtcac cctctgcctc tgagcaccaa taaagcgtct     1140

gcggcccca                                                             1149


<210> 2235
<211> 636
<212> DNA
<213> Homo sapiens

<400> 2235
ccaaggatga cctcaacaac caacaccatg tgtggcagct actacagaaa ctacaatggt       60

ggccatggct atgggtgctg tggctacgga ggcctgggct gtggttatgg cggctgtggc      120

tatgggtgct gtggctacgg aggcctgggc tttggctatg gaggcctgga ctgtggctat      180

ggaggcctgg gctgtggcta tggctccttc tgtggctgtg gctacagagg cctggactgt      240

ggctatggct gtggctatgg ctatgtctcc cactccttct gtggctgtgg ctataggtgc      300

ggctctggct atggctccag ctttggctac tactattgag gacaccatgg gagactctca      360

ccctctatcc tgtgacattg caattcacca attctgaagc ccacatgctc tgagcctttc      420

ccttgattga tgatatcctg cagtggaagt ctaatatgat ctgttgttga tctaccatct      480

aacccaaaaa taccctgagt ttccatcatg aagtgggata aggtgaagtt cacctgtcac      540

ttctcctttt atcaggatga tggtgtcaca gtgactcctt tgatgacttt catgctgtag      600

tttgtttctc tgctgaccta ataaacacat ttaatc                                636


<210> 2236
<211> 3420
<212> DNA
<213> Homo sapiens

<400> 2236
caacctgcag ccctcatctc cgccggcgag tagggccagg tgttgggagc tcccacgtgg       60

gacaagatgg tgtcttcggc gcagatgggc ttcaacctgc aggctctcct ggagcagctc      120

agccaggatg agttgagcaa gttcaagtat ctgatcacga ccttctccct ggcacacgag      180

ctccagaaga tcccccacaa ggaggtagac aaggctgatg ggaagcaact ggtagaaatc      240

ctcaccaccc attgtgacag ctactgggtg gagatggcga gcctccaggt ctttgaaaag      300

atgcaccgaa tggatctgtc tgagagagca aaggatgaag tcagagaagc agctttgaaa      360

tcctttaata aaaggaagcc tctatcatta gcgtttacag aaacgaaagg aaatgtcatc      420

tgcctgggta aagaagtctt taaaggaaaa aagccagaca aagacaatag gtgcaggtat      480

atattgaaga cgaagttccg ggagatgtgg aagagctggc ctggagatag caaagaggtc      540

caggttatgg ctgagagata caagatgctg atcccattca gcaaccccag ggtgcttccc      600

gggcccttct catacacggt ggtgctgtat ggtcctgcag gccttgggaa aaccacgctg      660

gcccagaaac taatgctaga ctgggcagag gacaacctca tccacaaatt caaatatgcg      720

ttctacctca gctgcaggga gctcagccgc ctgggcccgt gcagttttgc agagctggtc      780

ttcagggact ggcctgaatt gcaggatgac attccacaca tcctagccca agcacggaaa      840

atcttgttcg tgattgacgg ctttgatgag ctgggagccg cacctggggc gctgatcgag      900

gacatctgcg gggactggga gaagaagaag ccggtgcccg tcctcctggg gagtttgctg      960

aacagggtga tgttacccaa ggccgccctg ctggtcacca cgcggcccag ggccctgagg     1020

gacctccgga tcctggcgga ggagccgatc tacataaggg tggagggctt cctggaggag     1080

gacaggaggg cctatttcct gagacacttt ggagacgagg accaagccat gcgtgccttt     1140

gagctaatga ggagcaacgc ggccctgttc cagctgggct cggcccccgc ggtgtgctgg     1200

atcgtgtgca cgactctgaa gctgcagatg gagaaggggg aggacccggt ccccacctgc     1260

ctcacccgca cggggctgtt cctgcgtttc ctctgcagcc ggttcccgca gggcgcacag     1320

ctgcggggcg cgctgcggac gctgagcctc ctggccgcgc agggcctgtg ggcgcagacg     1380

tccgtgcttc accgagagga tctggaaagg ctcggggtgc aggagtccga cctccgtctg     1440

ttcctggacg gagacatcct ccgccaggac agagtctcca aaggctgcta ctccttcatc     1500

cacctcagct tccagcagtt tctcactgcc ctgttctaca ccctggagaa ggaggaggaa     1560

gaggataggg acggccacac ctgggacatt ggggacgtac agaagctgct ttccggagta     1620

gaaagactca ggaaccccga cctgatccaa gcaggctact actcctttgg cctcgctaac     1680

gagaagagag ccaaggagtt ggaggccact tttggctgcc ggatgtcacc ggacatcaaa     1740

caggaattgc tgcgatgcga cataagttgt aagggtggac attcaacggt gacagacctg     1800

caggagctcc tcggctgtct gtacgagtct caggaggagg agctggtgaa ggaggtgatg     1860

gctcagttca aagaaatatc cctgcactta aatgcagtag acgttgtgcc atcttcattc     1920

tgcgtcaagc actgtcgaaa cctgcagaaa atgtcactgc aggtaataaa ggagaatctc     1980

ccggagaatg tcactgcgtc tgaatcagac gccgaggttg agagatccca ggatgatcag     2040

cacatgcttc ctttctggac ggacctttgt tccatatttg gatcaaataa ggatctgatg     2100

ggtctagcaa tcaatgatag ctttctcagt gcctccctag taaggatcct gtgtgaacaa     2160

atagcctctg acacctgtca tctccagaga gtggtgttca aaaacatttc cccagctgat     2220

gctcatcgga acctctgcct agctcttcga ggtcacaaga ctgtaacgta tctgaccctt     2280

caaggcaatg accaggatga tatgtttccc gcattgtgtg aggtcttgag acatccagaa     2340

tgtaacctgc gatatctcgg gttggtgtct tgttccgcta ccactcagca gtgggctgat     2400

ctctccttgg cccttgaagt caaccagtcc ctgacgtgcg taaacctctc cgacaatgag     2460

cttctggatg agggtgctaa gttgctgtac acaactttga gacaccccaa gtgctttctg     2520

cagaggttgt cgttggaaaa ctgtcacctt acagaagcca attgcaagga ccttgctgct     2580

gtgttggttg tcagccggga gctgacacac ctgtgcttgg ccaagaaccc cattgggaat     2640

acaggggtga agtttctgtg tgagggcttg aggtaccccg agtgtaaact gcagaccttg     2700

gtgctttgga actgcgacat aactagcgat ggctgctgcg atctcacaaa gcttctccaa     2760

gaaaaatcaa gcctgttgtg tttggatctg gggctgaatc acataggagt taagggaatg     2820

aagttcctgt gtgaggcttt gaggaaacca ctgtgcaact tgagatgtct gtggttgtgg     2880

ggatgttcca tccctccgtt cagttgtgaa gacctctgct ctgccctcag ctgcaaccag     2940

agcctcgtca ctctggacct gggtcagaat cccttggggt ctagtggagt gaagatgctg     3000

tttgaaacct tgacatgttc cagtggcacc ctccggacac tcaggttgaa aatcgatgac     3060

tttaatgatg aactcaataa gctgctggaa gaaatagaag aaaaaaaccc acaactgatt     3120

attgatactg agaaacatca tccctgggca gaaaggcctt cttctcatga cttcatgatc     3180

tgaatccccc cgagtcattc attctccatg aagtcatcga ttttccaggt gttggtgaac     3240

tgcctgtgac tcctctcctc cccggcccct acccctcagg gataatgagt tcattgctgg     3300

gctagatgtt ttagccatga ttctgcctct gttttatacc tgcacacatc cttatctttg     3360

ttacatatga aatatctgta tcacgggtat attgagagaa ataaaggtga gagcattcac     3420


<210> 2237
<211> 1205
<212> DNA
<213> Homo sapiens

<400> 2237
atttgaaaca acaactttat tagcacctgg cactaggcgg agagaggcgg taagccgcga       60

ggaggaaagg gactcacgtc ccgctgtgga ccgatcctgc taagcagaga atcgctgtgg      120

ccggacgacg gggcgtcgag acaagaagaa agacgttggc aactcagagg actggttgcg      180

gcgttagaca agaaagcaag gcctttaagc agggattcgg ggtggacgtg ggggtgggcc      240

gaagcgaagc cggaaacagg aaactacaac tcccacaagg cctagggcca cgtcccgccg      300

tcctcggctg ctgagcctga tgggacaagt agttttgcga acggcttaac ctacagattg      360

aagaggtcgg aagctctgag gcccggggct tccggaggtc gcggagatgg aattggagca      420

gagagaaggg accatggcag ccgtgggctt tgaggagttc tcagcgccgc caggctcaga      480

gttggcgttg cctcccctat ttggtggcca catcctggag agcgagctgg agacggaagt      540

ggagtttgtg tcaggtggtc tgggcggctc agggctccgg gagcgagatg aagaggaaga      600

ggcagcccgg ggtcggcggc ggcgccagcg ggaattaaat cgcagaaagt accaggcact      660

aggtcggcgc tgccgggaga tcgagcaggt gaacgagcgg gtcctgaaca ggctccatca      720

ggtgcagagg ataactcgga ggctgcagca ggaacggagg ttcctcatga gagtgctgga      780

ctcctacggg gatgactacc gggccagcca gttcaccatt gtgctggagg atgagggcag      840

ccagggcacg gatgccccca ccccaggcaa tgcggagaat gagcctccag agaaagagac      900

actgtccccg cccagaagga ctcctgcacc cccagaaccc ggcagcccag cccccggtga      960

ggggcccagt gggcggaaga ggcggcgagt gccacgggat ggacgccgag caggaaatgc     1020

gctgactcca gagctggccc cggtgcagat taaggttgag gaagactttg gctttgaagc     1080

agatgaggcc ctggattcca gttgggtttc tcggggtcca gacaaactgc tgccctaccc     1140

gaccctggcc agcccagcct ctgactgacg catgcccaat aaactgaccc cacactcacc     1200

ccggc                                                                 1205


<210> 2238
<211> 3205
<212> DNA
<213> Homo sapiens

<400> 2238
attggtgagt ggggcagggc aggagggaac tgaagagtga gaaagcatta tttcagcaaa       60

aggtctttcc tcccttgctc tctcctccaa ccactggctc agcctctccg cccgctgcct      120

gtgaatgatg caatggaagg tgtgctgggg tcgccctgtg tcccgtgcat aggagcatct      180

cagcctccag gtcctctcct ttggggctca cggcaccccc atgctacgaa ccgcaggcag      240

ggacggcctc tgtcgcctgt ccacctactt ggaagaactc gaggctgtgg aactgaagaa      300

gttcaagtta tacctgggga ccgcgacaga gctgggagaa ggcaagatcc cctggggaag      360

catggagaag gccggtcccc tggaaatggc ccagctgctc atcacccact tcgggccaga      420

ggaggcctgg aggttggctc tcagcacctt tgagcggata aacaggaagg acctgtggga      480

gagaggacag agagaggacc tggtgaggga taccccacct ggtggcccgt cctcacttgg      540

gaaccagtca acatgccttc tggaagtctc tcttgtcact ccaagaaaag atccccagga      600

aacctacagg gactatgtcc gcaggaaatt ccggctcatg gaagaccgca atgcgcgcct      660

aggggaatgt gtcaacctca gccaccggta cacccggctc ctgctggtga aggagcactc      720

aaaccccatg caggtccagc agcagcttct ggacacaggc cggggacacg cgaggaccgt      780

gggacaccag gctagcccca tcaagataga gaccctcttt gagccagacg aggagcgccc      840

cgagccaccg cgcaccgtgg tcatgcaagg cgcggcaggg ataggcaagt ccatgctggc      900

acacaaggtg atgctggact gggcggacgg gaagctcttc caaggcagat ttgattatct      960

cttctacatc aactgcaggg agatgaacca gagtgccacg gaatgcagca tgcaagacct     1020

catcttcagc tgctggcctg agcccagcgc gcctctccag gagctcatcc gagttcccga     1080

gcgcctcctt ttcatcatcg acggcttcga tgagctcaag ccttctttcc acgatcctca     1140

gggaccctgg tgcctctgct gggaggagaa acggcccacg gagctgcttc ttaacagctt     1200

aattcggaag aagctgctcc ctgagctatc tttgctcatc accacacggc ccacggcttt     1260

ggagaagctc caccgtctgc tggagcaccc caggcatgtg gagatcctgg gcttctctga     1320

ggcagaaagg aaggaatact tctacaagta tttccacaat gcagagcagg cgggccaagt     1380

cttcaattac gtgagggaca acgagcctct cttcaccatg tgcttcgtcc ccctggtgtg     1440

ctgggtggtg tgtacctgcc tccagcagca gctggagggt ggggggctgt tgagacagac     1500

gtccaggacc accactgcag tgtacatgct ctacctgctg agtctgatgc aacccaagcc     1560

gggggccccg cgcctccagc ccccacccaa ccagagaggg ttgtgctcct tggcggcaga     1620

tgggctctgg aatcagaaaa tcctatttga ggagcaggac ctccggaagc acggcctaga     1680

cggggaagac gtctctgcct tcctcaacat gaacatcttc cagaaggaca tcaactgtga     1740

gaggtactac agcttcatcc acttgagttt ccaggaattc tttgcagcta tgtactatat     1800

cctggacgag ggggagggcg gggcaggccc agaccaggac gtgaccaggc tgttgaccga     1860

gtacgcgttt tctgaaagga gcttcctggc actcaccagc cgcttcctgt ttggactcct     1920

gaacgaggag accaggagcc acctggagaa gagtctctgc tggaaggtct cgccgcacat     1980

caagatggac ctgttgcagt ggatccaaag caaagctcag agcgacggct ccaccctgca     2040

gcagggctcc ttggagttct tcagctgctt gtacgagatc caggaggagg agtttatcca     2100

gcaggccctg agccacttcc aggtgatcgt ggtcagcaac attgcctcca agatggagca     2160

catggtctcc tcgttctgtc tgaagcgctg caggagcgcc caggtgctgc acttgtatgg     2220

cgccacctac agcgcggacg gggaagaccg cgcgaggtgc tccgcaggag cgcacacgct     2280

gttggtgcag ctcagaccag agaggaccgt tctgctggac gcctacagtg aacatctggc     2340

agcggccctg tgcaccaatc caaacctgat agagctgtct ctgtaccgaa atgccctggg     2400

cagccggggg gtgaagctgc tctgtcaagg actcagacac cccaactgca aacttcagaa     2460

cctgaggctg aagaggtgcc gcatctccag ctcagcctgc gaggacctct ctgcagctct     2520

catagccaat aagaatttga caaggatgga tctcagtggc aacggcgttg gattcccagg     2580

catgatgctg ctttgcgagg gcctgcggca tccccagtgc aggctgcaga tgattcagtt     2640

gaggaagtgt cagctggagt ccggggcttg tcaggagatg gcttctgtgc tcggcaccaa     2700

cccacatctg gttgagttgg acctgacagg aaatgcactg gaggatttgg gcctgaggtt     2760

actatgccag ggactgaggc acccagtctg cagactacgg actttgtggt ggttatttgg     2820

gatggacctg aataaaatga cccacagtag gttggcagcg cttcgagtaa caaaacctta     2880

tttggacatt ggctgctgaa tggtcctatc tgctggctct cccctgagat ctggacagag     2940

gaagatggga gggtgctcat caccccccca gcataatgat cagcctcctt cctagagaca     3000

gactcatgca gattgagatc aaaagtccct ctgcttggga tcaaattaat gtttgacaga     3060

gctggccagg cgtggtggct catgtatgta atcctagcac ttcgagaggc cgaggcaggt     3120

ggatcacgag gtcaggagtt tgagattagc ctggccaaga tggtgaaacc ctgtctctac     3180

taaaaataaa aaaaaattag ccagg                                           3205


<210> 2239
<211> 3715
<212> DNA
<213> Homo sapiens

<400> 2239
attggtgagt ggggcagggc aggagggaac tgaagagtga gaaagcatta tttcagcaaa       60

aggtctttcc tcccttgctc tctcctccaa ccactggctc agcctctccg cccgctgcct      120

gtgaatgatg caatggaagg tgtgctgggg tcgccctgtg tcccgtgcat aggagcatct      180

cagcctccag gtcctctcct ttggggctca cggcaccccc atgctacgaa ccgcaggcag      240

ggacggcctc tgtcgcctgt ccacctactt ggaagaactc gaggctgtgg aactgaagaa      300

gttcaagtta tacctgggga ccgcgacaga gctgggagaa ggcaagatcc cctggggaag      360

catggagaag gccggtcccc tggaaatggc ccagctgctc atcacccact tcgggccaga      420

ggaggcctgg aggttggctc tcagcacctt tgagcggata aacaggaagg acctgtggga      480

gagaggacag agagaggacc tggtgaggga taccccacct ggtggcccgt cctcacttgg      540

gaaccagtca acatgccttc tggaagtctc tcttgtcact ccaagaaaag atccccagga      600

aacctacagg gactatgtcc gcaggaaatt ccggctcatg gaagaccgca atgcgcgcct      660

aggggaatgt gtcaacctca gccaccggta cacccggctc ctgctggtga aggagcactc      720

aaaccccatg caggtccagc agcagcttct ggacacaggc cggggacacg cgaggaccgt      780

gggacaccag gctagcccca tcaagataga gaccctcttt gagccagacg aggagcgccc      840

cgagccaccg cgcaccgtgg tcatgcaagg cgcggcaggg ataggcaagt ccatgctggc      900

acacaaggtg atgctggact gggcggacgg gaagctcttc caaggcagat ttgattatct      960

cttctacatc aactgcaggg agatgaacca gagtgccacg gaatgcagca tgcaagacct     1020

catcttcagc tgctggcctg agcccagcgc gcctctccag gagctcatcc gagttcccga     1080

gcgcctcctt ttcatcatcg acggcttcga tgagctcaag ccttctttcc acgatcctca     1140

gggaccctgg tgcctctgct gggaggagaa acggcccacg gagctgcttc ttaacagctt     1200

aattcggaag aagctgctcc ctgagctatc tttgctcatc accacacggc ccacggcttt     1260

ggagaagctc caccgtctgc tggagcaccc caggcatgtg gagatcctgg gcttctctga     1320

ggcagaaagg aaggaatact tctacaagta tttccacaat gcagagcagg cgggccaagt     1380

cttcaattac gtgagggaca acgagcctct cttcaccatg tgcttcgtcc ccctggtgtg     1440

ctgggtggtg tgtacctgcc tccagcagca gctggagggt ggggggctgt tgagacagac     1500

gtccaggacc accactgcag tgtacatgct ctacctgctg agtctgatgc aacccaagcc     1560

gggggccccg cgcctccagc ccccacccaa ccagagaggg ttgtgctcct tggcggcaga     1620

tgggctctgg aatcagaaaa tcctatttga ggagcaggac ctccggaagc acggcctaga     1680

cggggaagac gtctctgcct tcctcaacat gaacatcttc cagaaggaca tcaactgtga     1740

gaggtactac agcttcatcc acttgagttt ccaggaattc tttgcagcta tgtactatat     1800

cctggacgag ggggagggcg gggcaggccc agaccaggac gtgaccaggc tgttgaccga     1860

gtacgcgttt tctgaaagga gcttcctggc actcaccagc cgcttcctgt ttggactcct     1920

gaacgaggag accaggagcc acctggagaa gagtctctgc tggaaggtct cgccgcacat     1980

caagatggac ctgttgcagt ggatccaaag caaagctcag agcgacggct ccaccctgca     2040

gcagggctcc ttggagttct tcagctgctt gtacgagatc caggaggagg agtttatcca     2100

gcaggccctg agccacttcc aggtgatcgt ggtcagcaac attgcctcca agatggagca     2160

catggtctcc tcgttctgtc tgaagcgctg caggagcgcc caggtgctgc acttgtatgg     2220

cgccacctac agcgcggacg gggaagaccg cgcgaggtgc tccgcaggag cgcacacgct     2280

gttggtgcag ctcagaccag agaggaccgt tctgctggac gcctacagtg aacatctggc     2340

agcggccctg tgcaccaatc caaacctgat agagctgtct ctgtaccgaa atgccctggg     2400

cagccggggg gtgaagctgc tctgtcaagg actcagacac cccaactgca aacttcagaa     2460

cctgaggctg aagaggtgcc gcatctccag ctcagcctgc gaggacctct ctgcagctct     2520

catagccaat aagaatttga caaggatgga tctcagtggc aacggcgttg gattcccagg     2580

catgatgctg ctttgcgagg gcctgcggca tccccagtgc aggctgcaga tgattcagtt     2640

gaggaagtgt cagctggagt ccggggcttg tcaggagatg gcttctgtgc tcggcaccaa     2700

cccacatctg gttgagttgg acctgacagg aaatgcactg gaggatttgg gcctgaggtt     2760

actatgccag ggactgaggc acccagtctg cagactacgg actttgtggc tgaagatctg     2820

ccgcctcact gctgctgcct gtgacgagct ggcctcaact ctcagtgtga accagagcct     2880

gagagagctg gacctgagcc tgaatgagct gggggacctc ggggtgctgc tgctgtgtga     2940

gggcctcagg catcccacgt gcaagctcca gaccctgcgg ttgggcatct gccggctggg     3000

ctctgccgcc tgtgagggtc tttctgtggt gctccaggcc aaccacaacc tccgggagct     3060

ggacttgagt ttcaacgacc tgggagactg gggcctgtgg ttgctggctg aggggctgca     3120

acatcccgcc tgcagactcc agaaactgtg gctggatagc tgtggcctca cagccaaggc     3180

ttgtgagaat ctttacttca ccctggggat caaccagacc ttgaccgacc tttacctgac     3240

caacaacgcc ctaggggaca caggtgtccg actgctttgc aagcggctga gccatcctgg     3300

ctgcaaactc cgagtcctct ggttatttgg gatggacctg aataaaatga cccacagtag     3360

gttggcagcg cttcgagtaa caaaacctta tttggacatt ggctgctgaa tggtcctatc     3420

tgctggctct cccctgagat ctggacagag gaagatggga gggtgctcat caccccccca     3480

gcataatgat cagcctcctt cctagagaca gactcatgca gattgagatc aaaagtccct     3540

ctgcttggga tcaaattaat gtttgacaga gctggccagg cgtggtggct catgtatgta     3600

atcctagcac ttcgagaggc cgaggcaggt ggatcacgag gtcaggagtt tgagattagc     3660

ctggccaaga tggtgaaacc ctgtctctac taaaaataaa aaaaaattag ccagg          3715


<210> 2240
<211> 3465
<212> DNA
<213> Homo sapiens

<400> 2240
ctctctcctc caaccactgg ctcagcctct ccgcccgctg cctgtgaatg atgcaatgga       60

aggtgtgctg gggtcgccct gtgtcccgtg cataggagca tctcagcctc caggtcctct      120

cctttggggc tcacggcacc cccatgctac gaaccgcagg cagggacggc ctctgtcgcc      180

tgtccaccta cttggaagaa ctcgaggctg tggaactgaa gaagttcaag ttatacctgg      240

ggaccgcgac agagctggga gaaggcaaga tcccctgggg aagcatggag aaggccggtc      300

ccctggaaat ggcccagctg ctcatcaccc acttcgggcc agaggaggcc tggaggttgg      360

ctctcagcac ctttgagcgg ataaacagga aggacctgtg ggagagagga cagagagagg      420

acctggtgag ggatacccca cctggtggcc cgtcctcact tgggaaccag tcaacatgcc      480

ttctggaagt ctctcttgtc actccaagaa aagatcccca ggaaacctac agggactatg      540

tccgcaggaa attccggctc atggaagacc gcaatgcgcg cctaggggaa tgtgtcaacc      600

tcagccaccg gtacacccgg ctcctgctgg tgaaggagca ctcaaacccc atgcaggtcc      660

agcagcagct tctggacaca ggccggggac acgcgaggac cgtgggacac caggctagcc      720

ccatcaagat agagaccctc tttgagccag acgaggagcg ccccgagcca ccgcgcaccg      780

tggtcatgca aggcgcggca gggataggca agtccatgct ggcacacaag gtgatgctgg      840

actgggcgga cgggaagctc ttccaaggca gatttgatta tctcttctac atcaactgca      900

gggagatgaa ccagagtgcc acggaatgca gcatgcaaga cctcatcttc agctgctggc      960

ctgagcccag cgcgcctctc caggagctca tccgagttcc cgagcgcctc cttttcatca     1020

tcgacggctt cgatgagctc aagccttctt tccacgatcc tcagggaccc tggtgcctct     1080

gctgggagga gaaacggccc acggagctgc ttcttaacag cttaattcgg aagaagctgc     1140

tccctgagct atctttgctc atcaccacac ggcccacggc tttggagaag ctccaccgtc     1200

tgctggagca ccccaggcat gtggagatcc tgggcttctc tgaggcagaa aggaaggaat     1260

acttctacaa gtatttccac aatgcagagc aggcgggcca agtcttcaat tacgtgaggg     1320

acaacgagcc tctcttcacc atgtgcttcg tccccctggt gtgctgggtg gtgtgtacct     1380

gcctccagca gcagctggag ggtggggggc tgttgagaca gacgtccagg accaccactg     1440

cagtgtacat gctctacctg ctgagtctga tgcaacccaa gccgggggcc ccgcgcctcc     1500

agcccccacc caaccagaga gggttgtgct ccttggcggc agatgggctc tggaatcaga     1560

aaatcctatt tgaggagcag gacctccgga agcacggcct agacggggaa gacgtctctg     1620

ccttcctcaa catgaacatc ttccagaagg acatcaactg tgagaggtac tacagcttca     1680

tccacttgag tttccaggaa ttctttgcag ctatgtacta tatcctggac gagggggagg     1740

gcggggcagg cccagaccag gacgtgacca ggctgttgac cgagtacgcg ttttctgaaa     1800

ggagcttcct ggcactcacc agccgcttcc tgtttggact cctgaacgag gagaccagga     1860

gccacctgga gaagagtctc tgctggaagg tctcgccgca catcaagatg gacctgttgc     1920

agtggatcca aagcaaagct cagagcgacg gctccaccct gcagcagggc tccttggagt     1980

tcttcagctg cttgtacgag atccaggagg aggagtttat ccagcaggcc ctgagccact     2040

tccaggtgat cgtggtcagc aacattgcct ccaagatgga gcacatggtc tcctcgttct     2100

gtctgaagcg ctgcaggagc gcccaggtgc tgcacttgta tggcgccacc tacagcgcgg     2160

acggggaaga ccgcgcgagg tgctccgcag gagcgcacac gctgttggtg cagctaccag     2220

agaggaccgt tctgctggac gcctacagtg aacatctggc agcggccctg tgcaccaatc     2280

caaacctgat agagctgtct ctgtaccgaa atgccctggg cagccggggg gtgaagctgc     2340

tctgtcaagg actcagacac cccaactgca aacttcagaa cctgaggctg aagaggtgcc     2400

gcatctccag ctcagcctgc gaggacctct ctgcagctct catagccaat aagaatttga     2460

caaggatgga tctcagtggc aacggcgttg gattcccagg catgatgctg ctttgcgagg     2520

gcctgcggca tccccagtgc aggctgcaga tgattcagtt gaggaagtgt cagctggagt     2580

ccggggcttg tcaggagatg gcttctgtgc tcggcaccaa cccacatctg gttgagttgg     2640

acctgacagg aaatgcactg gaggatttgg gcctgaggtt actatgccag ggactgaggc     2700

acccagtctg cagactacgg actttgtggc tgaagatctg ccgcctcact gctgctgcct     2760

gtgacgagct ggcctcaact ctcagtgtga accagagcct gagagagctg gacctgagcc     2820

tgaatgagct gggggacctc ggggtgctgc tgctgtgtga gggcctcagg catcccacgt     2880

gcaagctcca gaccctgcgg ctggatagct gtggcctcac agccaaggct tgtgagaatc     2940

tttacttcac cctggggatc aaccagacct tgaccgacct ttacctgacc aacaacgccc     3000

taggggacac aggtgtccga ctgctttgca agcggctgag ccatcctggc tgcaaactcc     3060

gagtcctctg gttatttggg atggacctga ataaaatgac ccacagtagg ttggcagcgc     3120

ttcgagtaac aaaaccttat ttggacattg gctgctgaat ggtcctatct gctggctctc     3180

ccctgagatc tggacagagg aagatgggag ggtgctcatc acccccccag cataatgatc     3240

agcctccttc ctagagacag actcatgcag attgagatca aaagtccctc tgcttgggat     3300

caaattaatg tttgacagag ctggccaggc gtggtggctc atgtatgtaa tcctagcact     3360

tcgagaggcc gaggcaggtg gatcacgagg tcaggagttt gagattagcc tggccaagat     3420

ggtgaaaccc tgtctctact aaaaataaaa aaaaattagc caggc                     3465


<210> 2241
<211> 623
<212> DNA
<213> Homo sapiens

<400> 2241
aaaccacatt cccaaaactt tccgttgcaa atttccaaac tttcccagtt tctaccctca       60

gcctttcaaa gtcccgcccc tcattccagt tcccacaccc agccttcttc aggtcccact      120

gctgaccgcc agaccaaact cctacagctg ccgcctgcat cccagaccgc ctgcatcccg      180

ctcggagcgg gtccgagccc tgctccctcc cagcgcacct tttccacgac acggatgaca      240

ccagcgatga gagagtctcg gtcctgatac ttcttagcgc tggtgtgcag ggcgcggatg      300

gcgtcggggc gccccgagga gctgtgggag gccgtggtgg gggccgctga gcgcttccgg      360

gcccggactg gcacggagct ggtgctgctg accgcggccc cgccgccacc accccgcccg      420

ggcccctgtg cctatgctgc ccatggtcga ggagccctgg cggaggcagc gcgccgttgc      480

ctccacgaca tcgcactggc ccacagggct gccactgctg ctcggcctcc tgcgccccca      540

ccagcaccac agccacccag tcccacaccc agcccacccc ggcctaccct ggccagagag      600

gacaacgagg aggacgagga tga                                              623


<210> 2242
<211> 2025
<212> DNA
<213> Homo sapiens

<400> 2242
atttcctgtt ttcttcctag accagtgggt cctccctgga ccccgggcga ggttgggagg       60

tctcggggca gctgagcgtg gccccaggcg ctcaccccat ggctaccgcg ttcatgctca      120

ggttcctcac atcttggggt gtggggtact aaaatttcga caggaggggt ggttccaccc      180

ctctcctcct tagctctttt ccctcctccc tgcatccaaa gaggacagcc acatcgtgct      240

ccccctcctg tggggaacac gtctcacttt cctctaatct ctccctgatc ttacacgaaa      300

ctcgtctatc ggggcgggtt cttcctccat ctctcagctc cttggaggaa acaggacctc      360

ctctagaagc tgaaggggcg cggatggcgt cggggcgccc cgaggagctg tgggaggccg      420

tggtgggggc cgctgagcgc ttccgggccc ggactggcac ggagctggtg ctgctgaccg      480

cggccccgcc gccaccaccc cgcccgggcc cctgtgccta tgctgcccat ggtcgaggag      540

ccctggcgga ggcagcgcgc cgttgcctcc acgacatcgc actggcccac agggctgcca      600

ctgctgctcg gcctcctgcg cccccaccag caccacagcc acccagtccc acacccagcc      660

caccccggcc taccctggcc agagaggaca acgaggagga cgaggatgag cccacagaga      720

cagagacctc cggggagcag ctgggcatta gtgataatgg agggctcttt gtgatggatg      780

aggacgccac cctccaggac cttcccccct tctgtgagtc agaccccgag agtacagatg      840

atggcagcct gagcgaggag acccccgccg gcccccccac ctgctcagtg cccccagcct      900

cagccctacc cacacagcag tacgccaagt ccctgcctgt gtctgtgccc gtctggggct      960

tcaaggagaa gaggacagag gcgcggtcat cagatgagga gaatgggccg ccctcttcgc     1020

ccgacctgga ccgcatcgcg gcgagcatgc gcgcgctggt gctgcgagag gccgaggaca     1080

cccaggtctt cggggacctg ccacggccgc ggcttaacac cagcgacttc cagaagctga     1140

agcggaaata ttgaagtcca gggagggagc gccccgggcc gcgtccgccc cgtcccacac     1200

tacgcccccg ccccactccc ggggcctgct aatctgaggc cgatccggga ccggcctcct     1260

tgcgtctccc attcccaaga ttgtcccgcc tctgccaatc cccgccgtcc ttccagccca     1320

cgacctgccg cgccgaggag cggcatctgt cccgtttccc gattgggtct gtcgtctctc     1380

tccgcctagc gacagattcc ttctattaag ggattggctc gctgagttct aagctctaaa     1440

tgggtcaact cctttgtttt ccgcctagcg acaagggatt tgctcgcacg gcattggctc     1500

catcccctag tcgctggaca gctctttttt tgattggctc aaatcctgta aagggcttga     1560

ccagtctcta catagtcacc gtccgctttt cctgagttct ccctcccaat tggctccagc     1620

ttcctggggg cgtggccaag ccctcctctt cccagaattg gcccggggcc ttcaatttac     1680

gttctttaca ctacggggac tggggtcgtc tttgcccacg tcccgacaac ttgttccctg     1740

accccctcag ggatggcccc aaactgtccc tgcctctggc accccctttc attggttcca     1800

tccatcccca caacagcctg ccaatcgaag cccgtccctg catccaggat ggtaccagct     1860

cccgcccctc gccccccacc tccacaggtg ccttaaaggg ccctcgtcca cccaaggtgg     1920

ggggcagggg ccctcactct ccggccctgg tgtgggggag agagtgaggg gttgggggat     1980

cggcagttgg gaggggcgct ctgagattaa agagttttac ctctg                     2025


<210> 2243
<211> 1911
<212> DNA
<213> Homo sapiens

<400> 2243
gggcgcgaca gctggaagag ccgaacggat aagagaagag gaggtgagag gagctgtaca       60

ccacaagagg cactgaggga ctcaggataa cgggatgaag ccgtcagtgc ccccagaaac      120

gaagcggccc cggacgaatt tctgagtcac cgtcgcgaga aagcgggctg agccgccatt      180

ttgaagcctg gcaaaccgaa gcaagaaatg ctgccgtgtt ggatctttgc cagccttcgt      240

gccgaatggg agcagggcgc ggatggcgtc ggggcgcccc gaggagctgt gggaggccgt      300

ggtgggggcc gctgagcgct tccgggcccg gactggcacg gagctggtgc tgctgaccgc      360

ggccccgccg ccaccacccc gcccgggccc ctgtgcctat gctgcccatg gtcgaggagc      420

cctggcggag gcagcgcgcc gttgcctcca cgacatcgca ctggcccaca gggctgccac      480

tgctgctcgg cctcctgcgc ccccaccagc accacagcca cccagtccca cacccagccc      540

accccggcct accctggcca gagaggacaa cgaggaggac gaggatgagc ccacagagac      600

agagacctcc ggggagcagc tgggcattag tgataatgga gggctctttg tgatggatga      660

ggacgccacc ctccaggacc ttcccccctt ctgtgagtca gaccccgaga gtacagatga      720

tggcagcctg agcgaggaga cccccgccgg cccccccacc tgctcagtgc ccccagcctc      780

agccctaccc acacagcagt acgccaagtc cctgcctgtg tctgtgcccg tctggggctt      840

caaggagaag aggacagagg cgcggtcatc agatgaggag aatgggccgc cctcttcgcc      900

cgacctggac cgcatcgcgg cgagcatgcg cgcgctggtg ctgcgagagg ccgaggacac      960

ccaggtcttc ggggacctgc cacggccgcg gcttaacacc agcgacttcc agaagctgaa     1020

gcggaaatat tgaagtccag ggagggagcg ccccgggccg cgtccgcccc gtcccacact     1080

acgcccccgc cccactcccg gggcctgcta atctgaggcc gatccgggac cggcctcctt     1140

gcgtctccca ttcccaagat tgtcccgcct ctgccaatcc ccgccgtcct tccagcccac     1200

gacctgccgc gccgaggagc ggcatctgtc ccgtttcccg attgggtctg tcgtctctct     1260

ccgcctagcg acagattcct tctattaagg gattggctcg ctgagttcta agctctaaat     1320

gggtcaactc ctttgttttc cgcctagcga caagggattt gctcgcacgg cattggctcc     1380

atcccctagt cgctggacag ctcttttttt gattggctca aatcctgtaa agggcttgac     1440

cagtctctac atagtcaccg tccgcttttc ctgagttctc cctcccaatt ggctccagct     1500

tcctgggggc gtggccaagc cctcctcttc ccagaattgg cccggggcct tcaatttacg     1560

ttctttacac tacggggact ggggtcgtct ttgcccacgt cccgacaact tgttccctga     1620

ccccctcagg gatggcccca aactgtccct gcctctggca ccccctttca ttggttccat     1680

ccatccccac aacagcctgc caatcgaagc ccgtccctgc atccaggatg gtaccagctc     1740

ccgcccctcg ccccccacct ccacaggtgc cttaaagggc cctcgtccac ccaaggtggg     1800

gggcaggggc cctcactctc cggccctggt gtgggggaga gagtgagggg ttgggggatc     1860

ggcagttggg aggggcgctc tgagattaaa gagttttacc tctgagataa a              1911


<210> 2244
<211> 3640
<212> DNA
<213> Homo sapiens

<400> 2244
ctggattaga atatctgccc tcctaaaggc aggcaggatg gcggtcagga tttagaacag       60

gccccggatc tagactttct gagtccaggt cccagccctg cctcttccag ttgtggccct      120

tcaagatgct gactgcccct gggcctgagt ttgcaactgt aaaatggggt gaactgtaac      180

taaagctcct gtctcatagt gtaggtgaaa gggtgggatg agaaggttga tcccatcttg      240

ggtccttgcg tggcttctgg gaggtggtgg ataaacctct tccttccctt ggggctttga      300

actccctgag tgagtcagat aggtgagatg ccaggtgtgg aatcccagca ctgaataggt      360

gctcagcaaa caccaacatc aatgatcgtg agtcataaaa ggcctgcaaa tttcattcag      420

actccagact ccctgctccc ttcaccctgg tgggctggac cacagctgtg cctgaatccg      480

tgcagtggcg gtgtgcttac tgcctcccgg aagagcgtct tccgcagccc agcagctctg      540

gctcaaccac gctggttaat ggggaagaaa atgaggcaca gagagggcca gtgagccatc      600

taaggtcaca cagcaggttt gagacagagt cagggcaagg acccagcccc cctgccctcg      660

ctcttctcac ccagtaagga gacgcaccct gcattgtctg cttagggccg acctgtcctg      720

caaacacaaa tccctgacct tgggggaatt cacagtctga tgcaggaggc agccaggtta      780

cagctgtcac aagctcaggt gacatgaatg ctcatggagg aagcccaggg catcggatgg      840

gctcctgaag tcatctgatg caccctgggg gatcagggac aacagaggac ctgccagaac      900

agtcttgtag gaaaagccgt gtggatttcc cagcacagag agcagcgcca gcaccatttc      960

agccccgact ctctgaggcc tcagtcatag aaccagccag ttccctctgg aaggaagtgt     1020

gctgggaagg tggccactca gacagtgtgg gaccccctat ggagcagact ggctggatct     1080

atgggcgagg gaaagtttct tccaccctag gatgagtgaa aggttggtgg ggaatggagc     1140

acaagtcatc aaggtcaggg accacgtttt ctgaaggcct cgggcctcag aggctctgga     1200

aggccgtgga ggcaggatgg cccaggagct ggggatggcc agaacaccta gagcctccag     1260

ggcctgccct gaggactatg gcgaggagta gcatcagctc cgggtgctga aggaaccccc     1320

tgggccttgt gcaggacact cttgacggga tggctgggcg acggagcagg gtggcatcat     1380

ccatcaaatt caacacaagc cccacgtgga attctaaatt ttctagacac catgttaaaa     1440

gagtaaaaaa agcagatgaa attccttttt tttttttttt ttgcccaggc tggcttcgaa     1500

ctcttgggct cggtgatccg cctgcctcgg cctcccaaag tgctggggtt gcaggcctga     1560

gccaccacgc ccggctcgtt cggctttatt gtactcagtc ttcagaaccc agtgcaggtt     1620

ttattgttag aggcctctct gctaggactc tctgctagga ctccctgcct ttccagtact     1680

ccctgttcac atgtggctgg cggctcccac agaggccagg gcagggccaa aggggaagga     1740

gtacagtgac ttggggcagg aggaatgggt tggggcagag gacgtcgcca gggtctgggc     1800

ctgcgaggac tggatggtga gaatcctggg gagtagcagg tttggggagg acacacagca     1860

ccgctgggac aaggtgggtg gagggtggtg agtgccatcc aggggacggg cgggcactct     1920

gagtgggtgg cgatgatgta ggccgccaag cctcagcccc ctctgtcctg ctctggcccg     1980

cagggcgcgg atggcgtcgg ggcgccccga ggagctgtgg gaggccgtgg tgggggccgc     2040

tgagcgcttc cgggcccgga ctggcacgga gctggtgctg ctgaccgcgg ccccgccgcc     2100

accaccccgc ccgggcccct gtgcctatgc tgcccatggt cgaggagccc tggcggaggc     2160

agcgcgccgt tgcctccacg acatcgcact ggcccacagg gctgccactg ctgctcggcc     2220

tcctgcgccc ccaccagcac cacagccacc cagtcccaca cccagcccac cccggcctac     2280

cctggccaga gaggacaacg aggaggacga ggatgagccc acagagacag agacctccgg     2340

ggagcagctg ggcattagtg ataatggagg gctctttgtg atggatgagg acgccaccct     2400

ccaggacctt ccccccttct gtgagtcaga ccccgagagt acagatgatg gcagcctgag     2460

cgaggagacc cccgccggcc cccccacctg ctcagtgccc ccagcctcag ccctacccac     2520

acagcagtac gccaagtccc tgcctgtgtc tgtgcccgtc tggggcttca aggagaagag     2580

gacagaggcg cggtcatcag atgaggagaa tgggccgccc tcttcgcccg acctggaccg     2640

catcgcggcg agcatgcgcg cgctggtgct gcgagaggcc gaggacaccc aggtcttcgg     2700

ggacctgcca cggccgcggc ttaacaccag cgacttccag aagctgaagc ggaaatattg     2760

aagtccaggg agggagcgcc ccgggccgcg tccgccccgt cccacactac gcccccgccc     2820

cactcccggg gcctgctaat ctgaggccga tccgggaccg gcctccttgc gtctcccatt     2880

cccaagattg tcccgcctct gccaatcccc gccgtccttc cagcccacga cctgccgcgc     2940

cgaggagcgg catctgtccc gtttcccgat tgggtctgtc gtctctctcc gcctagcgac     3000

agattccttc tattaaggga ttggctcgct gagttctaag ctctaaatgg gtcaactcct     3060

ttgttttccg cctagcgaca agggatttgc tcgcacggca ttggctccat cccctagtcg     3120

ctggacagct ctttttttga ttggctcaaa tcctgtaaag ggcttgacca gtctctacat     3180

agtcaccgtc cgcttttcct gagttctccc tcccaattgg ctccagcttc ctgggggcgt     3240

ggccaagccc tcctcttccc agaattggcc cggggccttc aatttacgtt ctttacacta     3300

cggggactgg ggtcgtcttt gcccacgtcc cgacaacttg ttccctgacc ccctcaggga     3360

tggccccaaa ctgtccctgc ctctggcacc ccctttcatt ggttccatcc atccccacaa     3420

cagcctgcca atcgaagccc gtccctgcat ccaggatggt accagctccc gcccctcgcc     3480

ccccacctcc acaggtgcct taaagggccc tcgtccaccc aaggtggggg gcaggggccc     3540

tcactctccg gccctggtgt gggggagaga gtgaggggtt gggggatcgg cagttgggag     3600

gggcgctctg agattaaaga gttttacctc tgagataaat                           3640


<210> 2245
<211> 2370
<212> DNA
<213> Homo sapiens

<400> 2245
agctaaggcc atgttaatac ggggctgtcc catctctctg cggggcgcga cagctggaag       60

agccgaacgg ataagagaag aggaggtgag aggagctgta caccacaaga ggcactgagg      120

gactcaggat aacgggatga agccgtcagt gcccccagaa acgaagcggc cccggacgaa      180

tttctgagtc accgtcgcga gaaagcgggc tgagccgcca ttttgaagcc tggcaaaccg      240

aagcaagaaa tgctgccgtg ttggatcttt gccagccttc gtgccgaatg ggagcaggtt      300

ggagggaggg agagccaata tacactatgg gctgattaag cccggttggc tgccatgttg      360

ttaacgagca ccgatttcct ctacttttgt cgaagaagtt tattgtgggt cagggacgtc      420

aggtcgcttg ccttcgttta ctgtggtcat gattgagcat atgaggacgg ccattattgt      480

tgggggcaaa tggaaatgct ctaggcgggg ccatttttct taggggcaag ctgtcgtcac      540

ccttgtcaac tggttcggat gaagcccctg tggccgccat cttgatctcg ggcggccccg      600

ataagggagg cggagtgtgc ggagaggagg cggggcaact gcgcggacgt gacgcaaggc      660

gccgccatgt cttttgaggg cggtgacggc gccgggccgg ccatgctggc tacgggcacg      720

gcgcggatgg cgtcggggcg ccccgaggag ctgtgggagg ccgtggtggg ggccgctgag      780

cgcttccggg cccggactgg cacggagctg gtgctgctga ccgcggcccc gccgccacca      840

ccccgcccgg gcccctgtgc ctatgctgcc catggtcgag gagccctggc ggaggcagcg      900

cgccgttgcc tccacgacat cgcactggcc cacagggctg ccactgctgc tcggcctcct      960

gcgcccccac cagcaccaca gccacccagt cccacaccca gcccaccccg gcctaccctg     1020

gccagagagg acaacgagga ggacgaggat gagcccacag agacagagac ctccggggag     1080

cagctgggca ttagtgataa tggagggctc tttgtgatgg atgaggacgc caccctccag     1140

gaccttcccc ccttctgtga gtcagacccc gagagtacag atgatggcag cctgagcgag     1200

gagacccccg ccggcccccc cacctgctca gtgcccccag cctcagccct acccacacag     1260

cagtacgcca agtccctgcc tgtgtctgtg cccgtctggg gcttcaagga gaagaggaca     1320

gaggcgcggt catcagatga ggagaatggg ccgccctctt cgcccgacct ggaccgcatc     1380

gcggcgagca tgcgcgcgct ggtgctgcga gaggccgagg acacccaggt cttcggggac     1440

ctgccacggc cgcggcttaa caccagcgac ttccagaagc tgaagcggaa atattgaagt     1500

ccagggaggg agcgccccgg gccgcgtccg ccccgtccca cactacgccc ccgccccact     1560

cccggggcct gctaatctga ggccgatccg ggaccggcct ccttgcgtct cccattccca     1620

agattgtccc gcctctgcca atccccgccg tccttccagc ccacgacctg ccgcgccgag     1680

gagcggcatc tgtcccgttt cccgattggg tctgtcgtct ctctccgcct agcgacagat     1740

tccttctatt aagggattgg ctcgctgagt tctaagctct aaatgggtca actcctttgt     1800

tttccgccta gcgacaaggg atttgctcgc acggcattgg ctccatcccc tagtcgctgg     1860

acagctcttt ttttgattgg ctcaaatcct gtaaagggct tgaccagtct ctacatagtc     1920

accgtccgct tttcctgagt tctccctccc aattggctcc agcttcctgg gggcgtggcc     1980

aagccctcct cttcccagaa ttggcccggg gccttcaatt tacgttcttt acactacggg     2040

gactggggtc gtctttgccc acgtcccgac aacttgttcc ctgaccccct cagggatggc     2100

cccaaactgt ccctgcctct ggcaccccct ttcattggtt ccatccatcc ccacaacagc     2160

ctgccaatcg aagcccgtcc ctgcatccag gatggtacca gctcccgccc ctcgcccccc     2220

acctccacag gtgccttaaa gggccctcgt ccacccaagg tggggggcag gggccctcac     2280

tctccggccc tggtgtgggg gagagagtga ggggttgggg gatcggcagt tgggaggggc     2340

gctctgagat taaagagttt tacctctgag                                      2370


<210> 2246
<211> 3075
<212> DNA
<213> Homo sapiens

<400> 2246
attgccccgg gaccaaggcg gggagaatgg tccagcccgc gttcggatgc tgacgtgcgt       60

tccacagggg gcagggctca aggagtcgcc tgagccgggg gggcggggcc atgggaggtt      120

cttccctggg gcggtggacg ggagggtgac ggcgcgttta taagagatcg gtgtttgcca      180

aggccgtgcc ggattctcga gagccaaggc ctgagagaag agctgatcac tagacggggc      240

gtttcgcata cactgaagcg agggaatgcg tcctcagtgc ttaccctgta gccggctcct      300

tccatagtcg ccgccgaagg ccccactgcc ccgcctcctc cttttcctag tcagcgtgtt      360

gtcacttccg gagaaaacag ttcccctccg ggccggacag tggtagcggc ccgacccgtt      420

ctagagaagg agcgggtgaa accatttttc agaagggggt tattccactg gaacctcgag      480

ggtggatcgg agtcacgtgg cgcagacgct gaaggtggat ccggctacgg agagtgcgca      540

ggcgcagtgt tcgccctctc gccacgaagt aaacaagtgg gagggtctga gagctgcacc      600

acctggggca agcacgcctt gaaacgccca cttccttctc catattgtat actggaattg      660

aagccaagga ggtaccattt tgctcgaggg catggcctaa gccggtcagc taaggccatg      720

ttaatacggg gctgtcccat ctctctgcgg ggcgcgacag ctggaagagc cgaacggata      780

agagaagagg aggtgagagg agctgtacac cacaagaggc actgagggac tcaggataac      840

gggatgaagc cgtcagtgcc cccagaaacg aagcggcccc ggacgaattt ctgagtcacc      900

gtcgcgagaa agcgggctga gccgccattt tgaagcctgg caaaccgaag caagaaatgc      960

tgccgtgttg gatctttgcc agccttcgtg ccgaatggga gcaggttgga gggagggaga     1020

gccaatatac actatgggct gattaagccc ggttggctgc catgttgtta acgagcaccg     1080

atttcctcta cttttgtcga agaagtttat tgtgggtcag ggacgtcagg tcgcttgcct     1140

tcgtttactg tggtcatgat tgagcatatg aggacggcca ttattgttgg gggcaaatgg     1200

aaatgctcta ggcggggcca tttttcttag gggcaagctg tcgtcaccct tgtcaactgg     1260

ttcggatgaa gcccctgtgg ccgccatctt gatctcgggc ggccccgata agggaggcgg     1320

agtgtgcgga gaggaggcgg ggcaactgcg cggacgtgac gcaaggcgcc gccatgtctt     1380

ttgagggcgg tgacggcgcc gggccggcca tgctggctac gggcacggcg cggatggcgt     1440

cggggcgccc cgaggagctg tgggaggccg tggtgggggc cgctgagcgc ttccgggccc     1500

ggactggcac ggagctggtg ctgctgaccg cggccccgcc gccaccaccc cgcccgggcc     1560

cctgtgccta tgctgcccat ggtcgaggag ccctggcgga ggcagcgcgc cgttgcctcc     1620

acgacatcgc actggcccac agggctgcca ctgctgctcg gcctcctgcg cccccaccag     1680

caccacagcc acccagtccc acacccagcc caccccggcc taccctggcc agagaggaca     1740

acgaggagga cgaggatgag cccacagaga cagagacctc cggggagcag ctgggcatta     1800

gtgataatgg agggctcttt gtgatggatg aggacgccac cctccaggac cttcccccct     1860

tctgtgagtc agaccccgag agtacagatg atggcagcct gagcgaggag acccccgccg     1920

gcccccccac ctgctcagtg cccccagcct cagccctacc cacacagcag tacgccaagt     1980

ccctgcctgt gtctgtgccc gtctggggct tcaaggagaa gaggacagag gcgcggtcat     2040

cagatgagga gaatgggccg ccctcttcgc ccgacctgga ccgcatcgcg gcgagcatgc     2100

gcgcgctggt gctgcgagag gccgaggaca cccaggtctt cggggacctg ccacggccgc     2160

ggcttaacac cagcgacttc cagaagctga agcggaaata ttgaagtcca gggagggagc     2220

gccccgggcc gcgtccgccc cgtcccacac tacgcccccg ccccactccc ggggcctgct     2280

aatctgaggc cgatccggga ccggcctcct tgcgtctccc attcccaaga ttgtcccgcc     2340

tctgccaatc cccgccgtcc ttccagccca cgacctgccg cgccgaggag cggcatctgt     2400

cccgtttccc gattgggtct gtcgtctctc tccgcctagc gacagattcc ttctattaag     2460

ggattggctc gctgagttct aagctctaaa tgggtcaact cctttgtttt ccgcctagcg     2520

acaagggatt tgctcgcacg gcattggctc catcccctag tcgctggaca gctctttttt     2580

tgattggctc aaatcctgta aagggcttga ccagtctcta catagtcacc gtccgctttt     2640

cctgagttct ccctcccaat tggctccagc ttcctggggg cgtggccaag ccctcctctt     2700

cccagaattg gcccggggcc ttcaatttac gttctttaca ctacggggac tggggtcgtc     2760

tttgcccacg tcccgacaac ttgttccctg accccctcag ggatggcccc aaactgtccc     2820

tgcctctggc accccctttc attggttcca tccatcccca caacagcctg ccaatcgaag     2880

cccgtccctg catccaggat ggtaccagct cccgcccctc gccccccacc tccacaggtg     2940

ccttaaaggg ccctcgtcca cccaaggtgg ggggcagggg ccctcactct ccggccctgg     3000

tgtgggggag agagtgaggg gttgggggat cggcagttgg gaggggcgct ctgagattaa     3060

agagttttac ctctg                                                      3075


<210> 2247
<211> 1096
<212> DNA
<213> Homo sapiens

<400> 2247
aagcgaccga gggactggga gtcgttagtg agagtttcac tcttgttgcc taggctggag       60

tgcaatggtg cgatcttggc tcatcacgac cttcgcctcc caggttcaag tgattgtccc      120

atttcagcct cccgagtagc tgggattaca ggatgacgcg gcatggcaag aactgcaccg      180

caggggccgt ctacacctac cacgagaaga agaaggacac agcggcctcg ggctatggga      240

cccagaacat tcgactgagc cgggatgccg tgaaggactt cgactgctgt tgtctctccc      300

tgcagccttg ccacgatcct gttgtcaccc cagatggcta cctgtatgag cgtgaggcca      360

tcctggagta cattctgcac cagaagaagg agattgcccg gcagatgaag gcctacgaga      420

agcagcgggg cacccggcgc gaggagcaga aggagcttca gcgggcggcc tcgcaggacc      480

atgtgcgggg cttcctggag aaggagtcgg ctatcgtgag ccggcccctc aaccctttca      540

cagccaaggc cctctcgggc accagcccag atgatgtcca acctgggccc agtgtgggtc      600

ctccaagtaa ggacaaggac aaagtgctgc ccagcttctg gatcccgtcg ctgacgcccg      660

aagccaaggc caccaagctg gagaagccgt cccgcacggt gacctgcccc atgtcaggga      720

agcccctgcg catgtcggac ctgacgcccg tgcacttcac accgctagac agctccgtgg      780

accgcgtggg gctcatcacc cgcagcgagc gctacgtgtg tgccgtgacc cgcgacagcc      840

tgagcaacgc caccccctgc gctgtgctgc ggccctctgg ggctgtggtc accctcgaat      900

gcgtggagaa gctgattcgg aaggacatgg tggaccctgt gactggagac aaactcacag      960

accgcgacat catcgtgctg cagcggggcg gtaccggctt cgcgggctcc ggagtgaagc     1020

tgcaagcgga gaaatcacgg ccggtgatgc aggcctgagt gtgtgcggga gaccaaataa     1080

accggcttgg gtgcgc                                                     1096


<210> 2248
<211> 1181
<212> DNA
<213> Homo sapiens

<400> 2248
cacttctgcc gcccctgttt caagggataa gaaaccctgc gacaaaacct cctccttttc       60

caagcggctg ccgaagatgg cggaggtgca ggtcctggtg cttgatggtc gaggccatct      120

cctgggccgc ctggcggcca tcgtggctaa acaggtactg ctgggccgga aggtggtggt      180

cgtacgctgt gaaggcatca acatttctgg caatttctac agaaacaagt tgaagtacct      240

ggctttcctc cgcaagcgga tgaacaccaa cccttcccga ggcccctacc acttccgggc      300

ccccagccgc atcttctggc ggaccgtgcg aggtatgctg ccccacaaaa ccaagcgagg      360

ccaggccgct ctggaccgtc tcaaggtgtt tgacggcatc ccaccgccct acgacaagaa      420

aaagcggatg gtggttcctg ctgccctcaa ggtcgtgcgt ctgaagccta caagaaagtt      480

tgcctatctg gggcgcctgg ctcacgaggt tggctggaag taccaggcag tgacagccac      540

cctggaggag aagaggaaag agaaagccaa gatccactac cggaagaaga aacagctcat      600

gaggctacgg aaacaggccg agaagaacgt ggagaagaaa attgacaaat acacagaggt      660

cctcaagacc cacggactcc tggtctgagc ccaataaaga ctgttaattc ctcatgcgtt      720

gcctgccctt cctccattgt tgccctggaa tgtacgggac ccaggggcag cagcagtcca      780

ggtgccacag gcagccctgg gacataggaa gctgggagca aggaaagggt cttagtcact      840

gcctcccgaa gttgcttgaa agcactcgga gaattgtgca ggtgtcattt atctatgacc      900

aataggaaga gcaaccagtt actatgagtg aaagggagcc agaagactga ttggagggcc      960

ctatcttgtg agtggggcat ctgttggact ttccacctgg tcatatactc tgcagctgtt     1020

agaatgtgca agcacttggg gacagcatga gcttgctgtt gtacacaggg tatttctaga     1080

agcagaaata gactgggaag atgcacaacc aaggggttac aggcatcgcc catgctcctc     1140

acctgtattt tgtaatcaga aataaattgc ttttaaagaa a                         1181


<210> 2249
<211> 3725
<212> DNA
<213> Homo sapiens

<400> 2249
atgacctgct gctcacaggt tcccccacgc cgcagaccga gtctcgctct gtcgcccagg       60

ttggactgca atggtttgaa cggtgtcccc gggagcatct gggactttgt ttccggcagc      120

ttctccccca gcccctcccc catcctgagt gccggccccc catcctcttc gagtgcaagt      180

ccaaacggag ctgagctggc ccgggtcagg cggcagctgg acgaggccaa gaggaagatc      240

cggcagtggg aggagtcctg gcagcaggtg aagcaggtct gcgatgcctg gcagcgagag      300

gcgcaggagg ccaaggagcg tgcccgtgtg gccgatagcg accggcagct ggcgctgcag      360

aagaaggagg aggtggaggc acaggtgaag cagctgcagg aggagctgga gggcctgggc      420

gtagcctcca cactgccggg gctgcggggc tgtggggaca tcggcaccat tcccctgccg      480

aagctgcact cgctgcagag tcagctgcgc ctggacctgg aggcggtgga cggcgtgatc      540

ttccagctcc gcgccaagca gtgtgtggcc tgccgggagc gggcccacgg tgctgtcctg      600

cggccctgtc agcaccacat cctctgtgag ccgtgtgcgg ccaccgcacc tgagtgcccc      660

tactgcaagg gccagcccct gcagtggtga cctcagcggg gacagccacc tcctgctggg      720

caccctggct ccagcgctcc tcctgaccac ggacatgtcg tcactcgctt ctggtgccac      780

cgacgtgagg accgaggctg ggagcccttc ctgttacacg ttatcatgag gctgggagcc      840

ccgcctgcgc ttggcctgac agcctttcct gtcacacgtt gtcacctatc tagtcctacc      900

gacggtttca aggtattttc ctcaaaaacc ttaaatgcaa acccacagaa cccgcctgcc      960

tgtccctgag gggcctggtg cctccgggat ccacgcggcg ctgtgatcac agcagtttgt     1020

ggtcctgaca ctactgtgac taggccactg ggagctgggg tctttcaaag cactttgtaa     1080

accgaggaat ttagttagag gttataaatt gctctaagct gctttctgtt tttttttaat     1140

atgcgataat atgaagcttt atatgtgtac tgtgaactta aatatttcat atcagtttat     1200

tgtcaattca tagtatgcta aatatattag atttcatatt ctgaaactag tacttatgaa     1260

atgagtgttt atctagtagt aagacctagg atttttacat tttccaatta agtgcaaata     1320

gtatttataa gcagagtgat tatggattga gatgttttta acttgatgga aggagctagt     1380

tttcctgagc ctgtgtgtgc accaggcact ggggctgatg ttccagcctc gtggcgtggg     1440

agcaggagag ctccgtcctg catttctgtg gtccgtggcc gctgtttctg tgcgcctgcg     1500

cctcggagag caagtgaagg agcatcatgg gttttgtttt ctcccttaac cctctgaaag     1560

acagtttgat actaacaaaa aacgcagcag aggggatccg acgtcagagc ttttagaatt     1620

acttttttaa gcagctgtct tctggctggg tgcggtggct catgcctgtg atcccagcac     1680

tttgggaggc gggtggatca cctaaggtca ggagttcaag accagcctgg ccaacatggt     1740

gcaaccccgt cttagtaaaa atacaaaaat tggcctggcg tgagagcggg cacctgtagt     1800

cccagctact cgggaggctg aggcaggaga atcgcttgaa cctgggaggc agaggttgca     1860

gtgagccgag atcgcgccac cgcactccag cccgggtgac agagcgagac tctggctcaa     1920

aaaaaaaaaa aaaaagctgt tttctgatta ctcagagctg tcctaggcaa tggtgctttg     1980

tagctccttg gagatgtcgc tgggcgtcct ggcaggggtc aggcagtgaa ctgggagagt     2040

ggttgcctcc ccagcacccg tgaccaccct ggtcctgctc gtgtgggaga tgctcgggcc     2100

gtgtgtgcgc cagggtccgg ggtgccgggt gtatgtggca gtcacctgac ccgcgctgcc     2160

agttatcatc ggagctcatc catgtggcca gtgaggtcac aggagaggac ccggccacag     2220

cctctcagtg gcctggagca cacgggggaa gcgacccccc ccaggtcccg gctctgctgt     2280

ggtcccctgt cccgtctgcc cctggagcga cagtgtggtt tcggccgcag cagaaacgtg     2340

actgagaacg catccccgcg atgacctgac ccttctgctc agggctggga ctgtccctag     2400

gagttgagca ggaacaggca tctgtggttt acggcgacct ggctctccgc gggccacgtg     2460

ggtggtgagg gcacacgagt gggaagcggc accgacgtgt ttctccccga ccgtggcttt     2520

gccaaagact tttaatagca ttttttaagt gcaaaacgtc taggtaaaaa tctttatcat     2580

cagtgaccaa attagaatgt atttaatata gtaggtggtt taagaactgt tttaacgtaa     2640

gacaaactga tagcaacatt ctgttgtttt aaaggaagtg ggtccgtgac attctgcagc     2700

tagtccacta ctccaaggta actatcgact tggtttcagt gaatctattt tgtttttaac     2760

tacagtgatt tattagctca gtatctagaa attacgtata ttttgtgcta ctgtcatcga     2820

tgtgtaaact ctgtttttat ttgtatttat gcacttggtt cccatttgga gcctctggtc     2880

ttttctggga taagtggtgt ctgccgagac atctcccggt tgtcagtggt caggagcagc     2940

tgagctctag tctgccagct gctctgctct ttctgggaag gaggtggcgc ccgcccctca     3000

gggtgtctcc agggctcagc ttccggggtg gtagagctgg ggagccccag gggtgggggg     3060

acagctggga gatggaggtg gcacctgctc ccctagatca gtactggctc tgaggacagg     3120

tgagcagtgg gaagaccaaa gaatggctgg cagcgctgcc agggttggaa atgggggcaa     3180

gatcctgggg ctgtgtgccc tggggcctcc ctcacctgtc ttggtggcca tggcctcagg     3240

gatggctcct aggtggctga ggcacagcag tggctggaag gtgccccgtg gaggctgagg     3300

tggaggcgcg cccagcagct cccccctgtg gccatggcgg gcacggggcg taggagctgg     3360

ctggcggccg gctctgcatg ttcttgttgc ctgtcgtctg taactctagt gttcgacatt     3420

cgccgtgata cagtggtgtc acgacgtgtg taactgtggt cagcagacct tgttccgcgt     3480

ggacgcctca agtggattaa tttctggaag cctcaatctg tatgtttgag tatttacatg     3540

agaatgttat ttgaatggaa ttttcttaac ccagaaggta gtatttataa tcatttactt     3600

gtagcgaact gtttaaagtt aacacttgtt taaatttttt tacactatag catttatgca     3660

atggtttaca gaattcatgg agttattttt atcagtatgg gaattaatta aaaccttgaa     3720

tcttt                                                                 3725


<210> 2250
<211> 3208
<212> DNA
<213> Homo sapiens

<400> 2250
acagcgggcg cgcaggccgg ccccggggcc tccatgatgg aggagcgagc ggccgccgcg       60

gtcgccgccg ccgcctcctc ctgccgtccg ctcggctcag gcgcgggccc tggccccact      120

ggggcggccc cggtctccgc ccctgccccc gggccgggcc cggcaggtaa gggaggcggc      180

ggcggaggca gccccgggcc cacggcgggc ccggagcccc tgagcctgcc ggggatcctg      240

cactttatcc agcacgagtg ggcgcgcttc gaagccgaga aagcccgctg ggaggccgag      300

cgcgccgagt tacaggctca ggtggccttc cttcagggag agaggaaagg gcaggagaat      360

ctaaagacgg acctggtgcg gcggatcaag atgctagagt atgcgctgaa gcaggaaagg      420

gccaaatatc ataaactgaa gtttgggaca gacctgaacc agggggagaa gaaagcagat      480

gtgtcagaac aagtctccaa tggccccgtg gaatcggtca ccctggagaa cagcccgttg      540

gtgtggaagg aggggcggca gcttctccga cagtacctgg aagaggtggg ctacacagac      600

accatcctcg acatgcggtc caagcgcgtc cgttccctgc tgggccgctc gctggagctc      660

aacggggcag tggagccgag tgaaggggcc cccagggctc caccaggccc tgcagggctc      720

agtggtgggg agtcgctgct ggtgaaacag atcgaggagc agataaagag gaacgcggca      780

ggcaaagatg gcaaagagcg cttgggcggc tcagtgctgg ggcagatccc cttcctgcag      840

aactgcgagg acgaagacag cgacgaggac gatgagctgg acagcgtgca gcacaagaag      900

cagcgtgtga agctcccatc caaggctctg gtgcccgaaa tggaagacga ggatgaggaa      960

gacgactctg aggatgctat caatgagttt gatttcctgg gctcaggaga ggatggggaa     1020

ggggctccag accctcggcg gtgcactgtg gatgggagcc cccatgagct ggaaagccgt     1080

cgggtcaaac tccaaggcat tctggctgac ctgcgggatg tggatgggct gcccccaaaa     1140

gtgactggcc cgcctcctgg cacaccccag ccccggccac atgaaggttc ctttggcttc     1200

tcctcagacg tcttcatcat ggacactatc gggggcgggg aggtgagcct gggggacttg     1260

gcagatctca ccgtcaccaa cgacaacgac ctcagctgcg atctgtctga cagcaaagat     1320

gcttttaaga agacgtggaa ccccaagttc accctgcgct cgcactacga cggcattcgt     1380

tccctggcct tccaccacag ccagtcggct ctgctcaccg cctccgagga cggcacgctc     1440

aagctctgga acctgcagaa ggcggtcacg gccaagaaga atgcggcgct agatgtggaa     1500

cctatacatg ctttccgggc tcacaggggc ccagtgttgg ctgtggctat gggcagcaac     1560

agtgaatact gctacagtgg cggggcagat gcctgcatcc atagttggaa gattccagac     1620

ctcagcatgg atccctatga tggctacgac ccaagcgtgc tgagccacgt cctggagggc     1680

cacggggacg ccgtgtgggg cctggccttc agtcccacct cccagcgcct ggcctcctgt     1740

tctgctgatg gcaccgtccg catctgggac cccagcagca gcagcccggc ctgcctctgc     1800

accttcccca cagccagcga gcacggggtc cccacctcag tggccttcac cagcaccgag     1860

cctgcccaca tcgtggcctc cttccgctct ggcgacaccg tcttgtatga catggaggtt     1920

ggcagtgccc tcctcacgct ggagtcccgg ggcagcagcg gtccaaccca gatcaaccaa     1980

gtggtgagtc atccaaacca gcctctcacc atcaccgccc acgacgacag gggcatccgc     2040

ttcctggaca atcggacagg taagccggtg cactccatgg ttgcacacct ggacgcagtc     2100

acctgcctag ccgtggaccc caacggcgca ttcctgatgt caggaagcca tgactgctcc     2160

ctgcgtctct ggagcctgga caacaaaacg tgcgtgcagg agatcacggc ccaccgcaag     2220

aagcacgagg aggccatcca cgctgttgcc tgccacccca gcaaggccct cattgccagt     2280

gctggcgctg atgccctggc caaggtcttc gtatgatgcc cacctggccc tgccctggcc     2340

gccacgctgg ctggggtgta gggccgggca ggtggggctg aggggactcc cagcctcgct     2400

ggaggtgcag aggcctggcc tctgtctgtt tgccatggag cctggtggtg ctaacggccc     2460

tttccccagg aatccctccc caacggctgc cttccccaag catccagcct ggggatgggc     2520

ccctttcagg aatcaccccc gaggatggcc tcggggtttc cccctgtgcc ctgacagccg     2580

ctcctggtat cagagctgct ttccagaggg cagcacagcc agggccgggt gtctttaggg     2640

atcagttttt ccaagactcc agaaggtgcc aggttctccc cttgagctcc tgctccccca     2700

tcccccatcc tcccagacct gggcaggagc tgtgctggga gaaagggtgg cagccgggag     2760

cctcagagct gagccccggc ctggctgccc ctcccctccg gccctctcca ctgctttcca     2820

gacactaacc aaggcttcca ggccagggat tgcccaacac tcctagggca gccctcccag     2880

cgccccatgg ggtcgcccat gggtagagac ggctttcttg tgcccctccc tggggcatgg     2940

agggtggagt gggcctcggg tccccctgaa ctccctgtat atctgtataa ataacgggat     3000

tttcatggcg ccgccccacc cgcattatca ctgtgtgatg gtctcagtca gtctcctccc     3060

tgtctccact ctttccctct atttatttca ctctcttgtt tggttctacc ctgcaccctc     3120

ggtccccttc caggttcctg tttataagcc ccaacccctc tgtccccatc ttgtatgtga     3180

aaacttgtct caataaaccc tttggagt                                        3208


<210> 2251
<211> 867
<212> DNA
<213> Homo sapiens

<400> 2251
gtaccattct tcaagaaacg gtttgaatca gactgccttt ccttttgtct tcattgtcat       60

aaacatctgc ccccgtgtgg ttctgactgg ccgcgaaccc ctacccgaag cttttattcc      120

atcattgtgc accgttggtg gggaatgctg tggcaacagg ccacgcctcc acttactggt      180

tggctttgcg caggcgccaa cggaagtggg tcgcaggaag aggaagtccc gcctctctct      240

cctcaggcag cagcaacgcg gaggaaacgg gagtgaacgg agagcgtagt gaccatcatg      300

ttttagcaca accccctcag accactctgt ggagaacaga ctgtcaggga acgtgggtgg      360

aggcagagag accagaaaga ttccaggaca gagatgacag aggcttaggc catggagcct      420

cctcaacaag cccaagagtg agatgacccc agaggagctg cagaagcgag aggaggagga      480

atttaacacc ggtccactct ctgtgctcac acagtcagtc aagaacaata cccaagtgct      540

catcaactgc cgcaacaata agaaactcct gggccgcgtg aaggccttcg ataggcactg      600

caacatggtg ctggagaacg tgaaggagat gtggactgag gtacccaaga gtggcaaggg      660

caagaagaag tccaagccag tcaacaaaga ccgctacatc tccaagatgt tcctgcgcgg      720

ggactcagtc atcgtggtcc tgcggaaccc gctcatcgcc ggcaagtagg ggccgcctgt      780

ctgttgacag aactcactcc tctgtcctat gaagaccgct gccattggtg ttgagaataa      840

taaagctctg tgtttttttc tagtggt                                          867


<210> 2252
<211> 2570
<212> DNA
<213> Homo sapiens

<400> 2252
tatcacagaa gaaattcgtg tctatagctt ttaaggactt gattacatca ttttcaagcc       60

tgatagtttt ggaatcacca ttagagctta agacacacct gccttcattt caaccacctg      120

tcttcatacc ctgacgaagt gcacctttta acactccttt gtccttggat tacttaagag      180

ttcccagaaa tacatttgcc accaacagag tagccaaatt tataaggaaa aatgattccc      240

aatggatatt tgatgtttga ggatgaaaat tttattgagt cttctgttgc caaattaaat      300

gccctgagga aaagtggcca gttctgtgat gttcgacttc aggtctgtgg ccatgaaatg      360

ttagcacaca gagcagtgct agcttgctgc agtccctatt tatttgaaat ctttaatagt      420

gatagtgatc ctcatggaat ttctcacgtt aaatttgatg atctcaatcc agaagctgtt      480

gaagtcttgt tgaattatgc ctacactgct cagttgaaag cagataagga attggtaaaa      540

gatgtttatt ctgcagcaaa aaagctgaag atggatcgag taaagcaggt ttgtggtgat      600

tatttactgt ctagaatgga tgttaccagc tgcatctctt accgaaattt tgcaagttgt      660

atgggagact cccgtttgtt gaataaggtt gatgcttata ttcaggagca tttgttacaa      720

atttctgaag aggaggagtt tcttaagctt ccaaggctaa agttggaggt aatgcttgaa      780

gataatgttt gcttgcccag caatggcaaa ttatatacaa aggtaatcaa ctgggtgcag      840

cgtagcatct gggagaatgg agacagtctg gaagagctga tggaagaggt ttattaacaa      900

aactaggata cccaagactg aagaaacaag aagaaacctc aagtgtattg acacgtaaag      960

aagcagcagt cctgccccag ttctcctaag aaaaatccgc tgtgggcaga gaacgatgat     1020

gatttaatgg ttcaaacctt gtactactca gctgatcaca agctgcttga tgggaaccta     1080

ctagatggac aggctgaggt gtttggcagt gatgatgacc acattcagtt tgtgcagaaa     1140

aagccaccac gtgagaatgg ccataagcag ataagtagca gttcaactgg atgtctctct     1200

tctccaaatg ctacagtaca aagccctaag catgagtgga aaatcgttgc ttcagaaaag     1260

acttcaaata acacttactt gtgcctggct gtgctggatg gtatattctg tgtcattttt     1320

cttcatggga gaaacagccc acagagctca ccaacaagta ctccaaaact aagtaagagt     1380

ttaagctttg agatgcaaca agatgagcta atcgaaaagc ccatgtctcc tatgcagtac     1440

gcacgatctg gtctgggaac agcagagatg aatggcaaac tcatagctgc aggtggctat     1500

aacagagagg aatgtcttcg aacagtcgaa tgctataatc cacatacaga tcactggtcc     1560

tttcttgctc ccatgagaac accaagagcc cgatttcaaa tggctgtact catgggccag     1620

ctctatgtgg taggtggatc aaatggccac tcagatgacc tgagttgtgg agagatgtat     1680

gattcaaaca tagatgactg gattcctgtt ccagaattga gaactaaccg ttgtaatgca     1740

ggagtgtgtg ctctgaatgg aaagttatac atcgttggtg gctctgatcc atatggtcaa     1800

aaaggactga aaaattgtga tgtatttgat cctgtaacaa agttgtggac aagctgtgcc     1860

cctcttaaca ttcggagaca ccagtctgca gtctgtgagc ttggtggtta tttgtacata     1920

atcggaggtg cagaatcttg gaattgtctg aacacagtag aacgatacaa tcctgaaaat     1980

aatacctgga ctttaattgc acccatgaat gtggctaggc gaggagctgg agtggctgtt     2040

cttaatggaa aactgtttgt atgtggtggc tttgatggtt ctcatgccat cagttgtgtg     2100

gaaatgtatg atccaactag aaatgaatgg aagatgatgg gaaatatgac ttcaccaagg     2160

agcaatgctg ggattgcaac tgtagggaac accatttatg cagtgggagg attcgatggc     2220

aatgaatttc tgaatacggt ggaagtctat aaccttgagt caaatgaatg gagcccctat     2280

acaaagattt tccagtttta acaaatttaa gaccctctca aactaacagg cttagtgatg     2340

taattatggt tagtagaggt acacttgtga ataaagaggg tgggtgggta tagatgttgc     2400

taacagcaac acaaagcttt tgcatattgc atactattaa acatgctgta catacttttt     2460

gggtttattt ggaaaggaat gcaaagatga aggtctgttt tgtgtacttt taagactttg     2520

gttattttac tttttggaaa agaataaacc aagaattgat tgggcacatc                2570


<210> 2253
<211> 1654
<212> DNA
<213> Homo sapiens

<400> 2253
aaacgtcatc gcgggcgcga cgcctgaggg acagtctggg gtttggctgt ccggacggtg       60

cagcggcgag gccggccgcg aagatgccag tggcggtgat ggcggaaagc gcctttagtt      120

tcaaaaagtt gctggatcag tgcgagaacc aggagctcga ggacgcttga tgtaatgggc      180

agaatcagaa tgcttcagga atctgtcgaa tttgtttctt ataatagccc ctggaggaat      240

tgctacaccc ccagtgtatg gtcagcttct agctttatat ttgctccata atgacatgaa      300

taatgcaaga tatctttgga aaagaatacc acctgctata aaatctgcaa attctgaact      360

tgggggaatt tggtcagtag gacaaagaat ctggcagaga gatttccctg ggatctatac      420

aaccatcaac gctcaccagt ggtctgagac ggtccagcca attatggaag cacttagaga      480

tgcaacaagg agacgcgcct ttgccctggt ctctcaagcg tatacttcaa tcatcgccga      540

tgattttgca gcctttgttg gacttcctgt agaagaggct gtgaaaggca tattagaaca      600

aggatggcaa gctgattcca ccacaagaat ggttctgccc agaaagccag ttgcaggggc      660

cctggatgtt tcctttaaca agtttattcc cttatcagag cctgctccag ttcccccaat      720

acccaatgaa cagcagttag ccagactgac ggattatgtg gctttccttg aaaactgatt      780

tatcactctg agttcaagat tcatcttcag aatcctgtat actgacaaac gtagaaatgt      840

aaagtttgta ttttcaattt attggatggc ttaagcacct cagcattcct tactatgtga      900

taaaatacat atagaatata agatatacta tatacatttt gtccataaac gttatgctga      960

atagttgttg aaacagttct cattttgtag tatttaataa tctggatgga gcctgtcagt     1020

attacagtta gttttctagt gactcataaa ataagatttc ctgtttcatg tagaatagtg     1080

tttgtcaact gtcttttctc tgtcccagca catgccgtac tcttatatgt accattggtt     1140

gataattata atgattcatt tggacttgaa gaaagattgt ccccaggcac agtatctgaa     1200

tcactgggga ttatgattca ccctctttgg agaacatgct ctcttttcac cccccacctc     1260

ctgagagcca ctaatgtaag atacagaaac atagctgagg aacaaataga ccatttccat     1320

actaaaccag tttgttaact ttagattttt tccaatagtg tgagtatatc cattgctggc     1380

agtggagggc ttgccatgaa aatgcaactt atttaagaca tttatgagac atattaactt     1440

gtgctgtcgc cttttagaag gagaaactta agtgtggaat gcattatatg ggcaaagaag     1500

ctatgaagat acatgataca ctttgtacaa ctatcctgca gcccattggt tgcttatatt     1560

tatcgcttgg ctcaagttct gccctttgga gaaatactga gcaagtcttt cattctctgt     1620

gtgacagccc tctgaatatt tgaagttgtt tgtt                                 1654


<210> 2254
<211> 6282
<212> DNA
<213> Homo sapiens

<400> 2254
agtctggtct ggagctggga cagcagctgc tgctgtggaa aggccagctg gcaagatgat       60

ggaagaaatc tccattatgg tagcctatga cgcccatgtt ttcagccagc tgcacgatga      120

agacttcctc actagtctgg tggccatcag caagcccagg tctatggtac caaccaagaa      180

gctgaagaaa tatgagaaag aatatcagac aatgcgagag agtcagctgc aacaggaaga      240

cccaatggat agatacaaga gggagaaccg aagattacag gaggccagca tgaggttgga      300

acaagagaat gatgaccttg cccatgaact agtaacaagc aaaattgctc tacggaatga      360

cttggatcag gcagaagaca aggcagatgt gttgaataaa gagctccttt tgaccaaaca      420

gaggctggtg gagactgaag aggagaagag gaagcaagag gaagagactg cccagctaaa      480

agaagtcttc aggaaacagc tagagaaggc agaatatgaa ataaagaaga ctacagctat      540

cattgctgag tataaacaga tctgttcgca gttgagtacc aggctggaga aacagcaagc      600

agccagcaag gaggagctgg aagtggtaaa gggtaagatg atggcatgca aacactgcag      660

tgacattttc agcaaggagg gtgctttgaa actagcagcc acaggcagag aggaccaggg      720

aattgaaaca gatgatgaga aggactcact taagaagcag ctgagagaga tggaactgga      780

actggcacaa accaaactgc agttggtgga ggccaagtgt aaaattcagg aacttgaaca      840

tcagagagga gcccttatga atgaaatcca agctgcgaaa aactcttggt ttagcaaaac      900

cctgaactct atcaaaacgg ccacgggcac ccagccattg cagccagcac cggtcaccca      960

gccacccaag gagagcacat agttccagcc ttacccaagc acaagagcac aatgttcaaa     1020

ccaatggaaa tctgggagga ttcttcctgg tgtccctttg aaggaaagtc aaggaggcca     1080

gaaaacaagc cagaattttt cagtagctct cactctttct tgtatgacac ttttcaaagg     1140

gatgctattt aaactgacct gttctatgtt gaatacctat tttccagctt ctggaaggcc     1200

atgttcagat ccatcatagt attacacatt attttgtttg cctgatgttt agttggaaat     1260

aagtaattca gaactaaatg cttttttatt tagaattatt cataattatt tttatcttac     1320

ataaaaatgg agacatctgt tattccaagg ttgaagtgat aagaagatct ttgtcacagg     1380

aaaaaaaaaa ttgaaaccta aacatcttaa gttttcagga tttattcaga taaagcacac     1440

tgtggggcca ggcatgacca ctctcaggtt tcctcctgag cctgattccc agggaagtgt     1500

taatcctgtc caaaggaaag aaccaatcag cgatcattgg tttactttca ttttctgttc     1560

ggtacatctg gaaatgaagt gccaggaata gacgggctgt tcagattata cgctaggtaa     1620

aaggaactga aattttaata agtgtaggtc aggatcattt gggctgtggt attctaacag     1680

atccttttaa gaatgccaca taggacttgt gagttcctaa gtacaccaaa gtatggacac     1740

agatgtgact tctggcaatt ataaagttaa aggtggatat tgcaccttac agacttaggg     1800

agcctttacc agagacgcct aaaaagcccc aggttcagcc attgtgctga atagagtgga     1860

atatagaacc agggacagag tatttcattt aacgttgata tatacttgct aaggaaacac     1920

taacaatact gtaactttgt taaaggacat agtattgaaa tgggaaatag aggtcaggct     1980

cacatcatct tagtttaatg ctgggcaact ttttctgatt tctgtagttc cctgaaaatg     2040

tgtccttcgt acccataaag agatacaaat gcatttgtaa catttttgat tgaatataaa     2100

acctttacag aaatacttat ctcatggaaa ggtaaagcta ttgtttaaaa attagtggaa     2160

atattttttc aattatattt aacatgccta taaaaatagt ccttgcagga aattatttga     2220

taagagcaaa actattttta ttttataaac tattttggag gcctctgatc ctttcaaacc     2280

aaccaaacta ctattagata tgtacaataa catttgttga tattaatcat tggcctcatt     2340

gttgaacata ttatttgcaa agaatcttaa actctgtagt gccagaatga ttctcatctg     2400

tgccatattt tgcaattaaa agtaacacac ccttagaaga atcaaataag agccatctac     2460

atcccaggag gatgcaccaa gttgctcaca gtggatcttt tcctctaaaa tgatctttta     2520

tgttctaaaa agtgaaatcc cctttatctg tgtttatatt ctctacagcc cataaaactg     2580

atgtgattgt tatgttatac tcatcagata atacttttct tacataaatc tttcattgtt     2640

gttctgacat ctttcattac aaaatttatt ttcttaacaa aaaggaacat aacccagcat     2700

tccaagtgtc tgtgttggct ttaacattct ctacatggtg gtctagataa gctaattttt     2760

tttttttttt ttttgtaaaa tgtaatagct agaaaatgtt atcttggcgc ttgtttttgt     2820

aaatcattta gtataggctg ttagctttac tggtacttta cgctttgatt ccaagaagcc     2880

ttgtgcagtt gccttatcaa atggccagct aaattaaaga tgctcttttg tgttgtgaat     2940

ttcatagttc tgtacagagc ttgtttcaat ttacaaaaat aagtacattc cacagaatgc     3000

ctaaagtgtg taattttctt taaataatag taggtgaggg agaaacataa tggctctagg     3060

tcaatccctt atctaaagac cttgttcaac ttcatagtcc ctttcctttt aaagaggaga     3120

agagaaaaat cccccctggc caggcatggt ggctcacatc tgtaatccca gcactttggg     3180

aggctgaggt gggtggatca cctaaggtca ggagtttgag accagcctgg ccaacatggt     3240

gaaaccctat ctctactgca aaatacaaaa attagccggg cttggtggcg ggtgcctgta     3300

atcccagcta ctcgggaggt tgaggcagga gaatcacttg aacccaggag gcagaggttg     3360

cagtgggcca agattacggc attacattcc atccagcctg ggcgacaaga gcaaaattcc     3420

gtctcgaaaa atcaccaggt acatacctct caagtttgat aagtccatct tttgagtttt     3480

cttttagctc tttcaaaaga ttacgagggc aatacatatt tttttttttt ttattctcca     3540

gccccatatc atacttgggt atgcctgttg gtaccataag cctaaactct ccttcactgc     3600

aatgcctttg agtcagtagc aatagtaaag actagaaaca aagaaaattc agaatttggt     3660

atgtgatatg attgttcata caatatgtta taatagcaat attccaaaca atatgtcctt     3720

cactgtctat tgttggaaaa ctcatgcatc ccagcatgaa gtaactccta gttttaattt     3780

tagttatttt gagatatatt tgagaattgc atctcttctc ttgaatttca cttagaagag     3840

attaaccagc caaatatcca ggaaagtttc aaaacattct agtgtttttc atcctttgct     3900

aggatgcact ctgtacaaaa cattcctctg aaaatctaat atttgcagta tctaagaatt     3960

gatcatttct attttcatta aattctgtgg aaaaaattaa atgaatgaaa ttcaacttca     4020

taattcagtt catcagcttt tgtatcttga gaatctaaac acgtctttaa atctgaaaga     4080

aaccaagctg gattttgcag tgcatatgtt tgctagcttc ccacatcctg aaccatgtca     4140

aaatttggtt ttatttagtt acatataatt taatgcaaag aaattctgtt acttaatgtt     4200

ctgtttattt atgagtgcct atcaggaaca ctaataggaa tgccattcaa ccagtgtctt     4260

ctgcccctct cccagctgtt aaattagtac ttcttcattg gctttctgaa atgtcctgag     4320

taaagtagaa aagcaacctt tgtatggatg tggggatatt taatagtatg tatcttgttt     4380

catttttttc ctatgatgta ttaatattta tttttctcca acccctgctc cattttctta     4440

aaatattttc cagttaataa ctagttgctt tatttcctag ctgaagtgag aaaaccaacg     4500

gaaaacaata cagatttggg cagaggagat agagttacat ctttaaagga gtgagccagt     4560

cacccaggag aatcacatgt gtaactgatg taggggttta agtcttcata ctttcactaa     4620

aatctgtcta ctaactctcc caccaacctt tgcatcaaac acttaggtac ctgcctgatt     4680

aggggggccc ctttaaggga aaaaactttt aaaaaattaa atgccttggt tttgttttat     4740

cttctgggaa agaacacttt tacttgatta gcaagatgat tatattatat aacttgccct     4800

taaaaacact ccaaaatact gactcctttt ctccaattac aaatgagtgt gaagaaattc     4860

tgttgtatga tttgaacact attaggtttg tatgtgtgtt taattggaag aattttatat     4920

agagtatctc tgctgctttt gtttacctgg gtaccacaca accaaataca cattgagatt     4980

tcaagaaatg atgatgaaag ccagaaggcc agaccacagc tctgcagcct gtttcctaca     5040

accagatata aaactctttc tcgtcgccat gctgatagtc acactgaact agaactgtcc     5100

caacacattc ttcctctctc ataatggctt ccatttaata caggcaaagc cctttacctt     5160

agcaaattct ttatctttca aaagtgacca aaatgaggac ttcaaccttg gctgcacctc     5220

aataggagat gctgatcttg agttgtaatg agaaaagtgg gcatatagga gattttagtg     5280

actgcagtca gctgtctggc attcctttct cagtttgcat ctaaaagact acatatgtca     5340

agcttatctc cacctgaatt tgctgcctgc tataaaaaca tttcattaat atatcccatt     5400

cttcctacct ccatctctgg tttgtcatta gtggtattct gaaaagctta agaaaaaaga     5460

atcattgagt agaaagtgaa cattttaagt tattttcctt tttcattggc aattagttaa     5520

catgtaaaat cttttccatt aaactgtata acttttaata actatatatt atatatggga     5580

taaaatatat ggactgaatt gtgagaatat aaatgcatcg aaagactctg gtgtcatgaa     5640

agcacaagaa taaggctgga gatggtccca gatccaagat gtcccaaaag ccttttgtat     5700

cagtttctct atttttggta ttttgcataa tgcatggatc cttagttcaa atgagggaca     5760

aagtttctca gtcagcccca cttcctttct ttctaactcc tacctttccc ttgcagagga     5820

ggtagtagag attctggaat tgtctatttt tatgaattcc attattttgt ccatggcatc     5880

tctaatgaaa acaggttcta gaataaagga gttgattagt ctgaacagta ctaattaact     5940

acaaaataaa cgttagtgat cagcctcttc ctctataaac aatgaccaat tagacgtttc     6000

cgtaattcca tgtattatgt atagtacact ctataaatgt aaatgtaatg cttgtctaaa     6060

aagtgcaatt tattgtacat tgtcccaaca aatgtttact tttataatcg ttatgaactt     6120

gaattggatt agtatcttgt ttttatgtgt gaatgaagcc ttgtgaaata aacaaatgca     6180

actgagaagg taacaaggtg actgtttttg tgagccagtg atgttttcaa tgctttgtgt     6240

tgcccctttg gccccattaa gcagtaataa acatttgttc tg                        6282


<210> 2255
<211> 4967
<212> DNA
<213> Homo sapiens

<400> 2255
gcggtgtgtg gcaggcggca gcggcgctgg cggccgagtg cgcttgtcac gcgtggcggt       60

gcgtggttgc taggggcgcc tgaggctgcc gggtagccca gcaggccgag ggaggaagta      120

gcgtggagcc ggtgccgagc cggggcgaag ctggatcccc tagatagact gtcttcaagc      180

tcactgatat tttcctctgc ttgatccatt gtgctgttga gagcctctag taaatttttc      240

agactgacag acttcaagga tgcagctgct actaccggag gtgtgtggca ccttacctca      300

gcaaggccat gagaccgtgt ggccatgatg tgggcccctc atggcctcag caggaacaca      360

gcactatagt attggcctcc gccagaaaaa cagcttcaag cagagtggtc cctcaggcac      420

agtacctgcc acgccacctg agaaaccctc ggagggcaga gtctggcctc aggcccatca      480

gcaagtgaag ccaatctgga agctggaaaa gaagcaagtg gagacactgt cagcagggtt      540

gggcccaggc ctcttgggcg tcccacccca gccagcatat ttcttttgcc ccagcacttt      600

atgtagctct gggaccacgg ctgtcattgc aggccacagc agttcctgtt acctacactc      660

tctcccggac ttgttcaaca gcaccctgct ataccgccgc tccagctata ggcaaaaacc      720

gtaccagcaa ctggagtctt tctgcttgcg ttcgagcccg tcagaaaaaa gccctttttc      780

tctccctcaa aagagcctcc ctgtcagtct cactgccaac aaggccactt cttccatggt      840

cttctccatg gcccagccca tggcctcctc atccacagaa ccatacctct gcttggcagc      900

ggctggggaa aacccttcag ggaagagcct ggcctctgcc atctcaggga agatcccatc      960

tccactctct tcctcctata agcccatgct gaataataat tccttcatgt ggccaaatag     1020

cacgccagtg cctttattgc agaccacaca gggcctgaag ccagtatcgc cacccaagat     1080

ccagcctgtc tcctggcatc attcaggggg tactggagac tgtgcaccgc agcctgttga     1140

ccataaggtg cccaaaagca ttggcactgt cccagctgat gccagtgccc atatcgcctt     1200

gtctaccgct agctcccacg acacatccac caccagtgtt gcctcttcct ggtataaccg     1260

gaataactta gccatgaggg cagagccact ttcctgtgct ctggatgaca gctctgattc     1320

ccaggatcca actaaggaga ttcggttcac tgaggccgtg aggaaattga ccgcaagagg     1380

ctttgagaag atgccgaggc aaggctgcca gcttgaacag tctagtttcc tgaaccccag     1440

cttccagtgg aatgtcctca acaggagcag gcggtggaaa cctcctgcgg taaatcagca     1500

gtttcctcag gaggatgctg gatcggtcag gcgggtcctc cctggtgcct cagatacctt     1560

ggggttggac aatacagtct tctgtaccaa gcgtatcagc attcacctcc ttgcctcaca     1620

tgccagtggg ctcaatcaca accctgcctg tgaatctgta attgactcct cagcatttgg     1680

agaaggcaaa gctccaggtc ccccttttcc tcaaactctt ggcatagcca acgtggccac     1740

ccgcctctct tccatccagc tgggccagtc tgagaaggag agacctgagg aggccaggga     1800

gctggactca tctgataggg atattagttc agctactgac ctccagccag atcaggctga     1860

gactgaagat acagaagaag aactagtaga tggtttggaa gactgttgta gccgtgatga     1920

gaatgaagag gaggagggag actcagagtg ctcctcatta agtgctgtct cccccagcga     1980

atcggtggcc atgatctcta gaagctgtat ggaaattctg accaaacccc tttccaatca     2040

tgagaaagtt gtccgaccag ccctcatcta cagtctcttt cccaacgttc cccctaccat     2100

ctattttggc actcgggatg agagagtgga gaaacttccc tgggaacaga ggaagttgct     2160

ccgatggaag atgagcacag tgacccccaa cattgtcaag cagaccattg gacggtccca     2220

cttcaaaatc agcaaaagaa acgatgactg gctgggctgc tggggtcacc acatgaagtc     2280

tcctagtttc cgatccattc gagagcatca gaagctaaac catttcccag gctcattcca     2340

gattgggagg aaggaccggc tatggcggaa cctgtcacgt atgcagagcc gctttggcaa     2400

gaaggagttc agtttcttcc cccagtcctt tatcctgccc caggacgcca agctcctgcg     2460

caaagcgtgg gagagcagca gccgccaaaa gtggattgtg aagccaccag catcagctcg     2520

aggcattggc atccaggtta ttcacaagtg gagtcagctc cccaagcgaa ggcccctcct     2580

ggtacagagg tatctacaca aaccctacct catcagcggc agcaagtttg acctgcggat     2640

ctatgtttat gtcacttcct acgatcctct gcggatttac ctcttttcag atggactggt     2700

ccgctttgcc agttgcaagt attcgccttc catgaagagc cttggcaata agttcatgca     2760

cctgaccaac tacagtgtca ataaaaagaa tgccgagtac caggccaatg cagatgaaat     2820

ggcttgccag ggccacaaat gggcactgaa ggctttgtgg aactacctga gccagaaggg     2880

agtcaatagc gacgccatct gggagaagat aaaggatgtt gttgtcaaaa ctatcatctc     2940

gtcagagccc tatgtgacca gcctgctcaa gatgtatgtg cgacggccct atagctgcca     3000

tgaactcttt ggttttgaca tcatgctaga cgaaaacctc aagccctggg tcctggaagt     3060

caacatttcc ccaagcctcc actccagctc tccactggat atcagcatca aaggccagat     3120

gattcgtgac cttctgaatc tggcaggttt tgtcctgccc aatgcagagg atatcatttc     3180

cagccccagc agctgcagca gctccaccac cagcctgccc acctcccctg gggacaaatg     3240

tcgaatggct ccagagcatg tcactgcaca gaagatgaag aaagcctatt atctgaccca     3300

gaaaattcct gatcaggact tctatgcatc tgtgctggat gtcctgacac cagatgatgt     3360

tcggattctg gttgagatgg aagatgagtt ttctcgccgt ggtcagtttg aacgaatttt     3420

tccttctcat atctcctctc gctatctccg cttttttgag cagccacgat atttcaacat     3480

tctcaccacc caatgggaac agaaatacca tggcaacaag cttaaaggag tagatctgct     3540

ccggagttgg tgctacaaag ggttccacat gggagttgtc tctgattctg ctccagtgtg     3600

gtctctcccg acatcacttc tgactatctc aaaggatgac gtgatactca atgccttcag     3660

caaatcagag actagcaagc tgggaaaaca aagctcctgt gaggttagcc tactactctc     3720

tgaagacggg accacgccca aatccaagaa gactcaagct ggcctttccc cttatcccca     3780

gaaacccagt tcctcaaagg acagtgagga caccagcaaa gagcccagcc tttctaccca     3840

gacgttacct gtgatcaagt gctctgggca gacttcaaga ctttctgctt cctccacttt     3900

ccagtcaatc agtgactccc tcctggctgt gagcccataa ctggcctctc tccaaaagcc     3960

tctgcccagg agcatgggca tcagctacct cacgggaacc agcctgctgt tcagaccagt     4020

ctgaccccct acccctttca ccctgtccct cctcagagta ttttttgaag tggttgcatt     4080

atagagatgg gtatttgtag ggccggaggg atggtagtga tggggagaag gtgaggaagg     4140

gtcaccctct gtcacctgtc tgcctggctg gcacctcata tctcagcaga gaagccagtg     4200

gtggccacgc agccttataa agcaggtttt ggtttctacc ttaagtgagc catgtgtggt     4260

ttgtctgggg gccctggtgt ggttgctgag ttgtagctca agaggagaaa acatacagaa     4320

catatttgga ccggaaatcc tttgttctga atttgagggg gtcttctgag gtccttactt     4380

ccttaggtct ttcctcaccc ctctcccacc gctgtcctga ggagaaaccc ttgaacttcc     4440

tcagtagaca ggcggagagg ccacaacatg ccgaacccat ttcctgtcat cctagtcttg     4500

ggtcttcacc gcctccttcc aaatacccac cctgccagca gccctaggtc ttcctgttct     4560

gaccccccat cactgctcgt tcagccttct agatgtctct ctcgtggaca tctgttcttt     4620

agctgttggc tttctctgag gtgtgagagg gtctatgaac tttgtgaatt tcccatggcc     4680

ccagtgaagg agcccagata atcccagtag ctgttacctg tctccatgta tcaaaggaca     4740

cagtccaggg ggagggtgga aggagatgtg gtttctctat agtgcaacaa acatggtttc     4800

tcaatgttct gctgtgcagc aagcagggtc tggcggcttg gtaggtgggt ttcaggagca     4860

gtcactattg taggatgggc ttccaatcaa acctcagact aaactcttgt actgaactga     4920

ttctacctcc ctcctctaga ctcagtaaac agtgactatt caataaa                   4967


<210> 2256
<211> 8073
<212> DNA
<213> Homo sapiens

<400> 2256
agaattcaag agcagttaga aagttctttt acaggtttga cagatgaaaa agtgaaggca       60

tatctttctc ttcaccccca ggtattagat gaatttgtat ctgaaagtgt tagtgcagag      120

acagtagaga aatggctgaa gaggaagaac aacaaatcag aagatgaatc agctcctaag      180

gaagtcagca ggtaccaaga tacgaatatg cagggagttg tatatgaact aaacagctat      240

atagaacaac ggttggacac aggaggagac aaccagctac tcctctatga actgagcagc      300

atcattaaaa tagccacaaa agccgatgga tttgcactgt atttccttgg agagtgcaat      360

aatagcctgt gtatattcac gccacctggg ataaaggaag gaaaaccccg cctcatccct      420

gctgggccca tcactcaggg caccaccgtc tctgcttatg tggccaagtc caggaaaaca      480

ctgctagtag aagacatcct tggagatgaa cgatttccaa gaggtactgg actggaatca      540

gggactcgta tccagtctgt tctttgctta ccaattgtca ctgcaattgg tgacttgatt      600

ggtattctcg agctgtatcg gcactggggc aaagaagcct tctgtcttag tcaccaggag      660

gttgcaacag caaatcttgc ctgggcttca gtagcaatac atcaggtgca ggtatgcaga      720

ggccttgcca aacagacaga attgaatgac ttcctactcg acgtatcaaa aacatatttt      780

gataacatag ttgcaataga ttctctactt gaacacataa tgatatatgc aaaaaacctg      840

gtgaatgccg atcgttgtgc gcttttccag gtggaccata agaacaagga gttatattca      900

gacctttttg atattggaga ggaaaaggaa ggaaaacctg tcttcaagaa gaccaaagag      960

ataagatttt caattgagaa aggaattgct ggccaagtag caagaacagg ggaagtcctg     1020

aacattccag atgcctatgc agacccacgc tttaacagag aagtagactt gtacacaggc     1080

tacaccacgc ggaacatcct gtgcatgccc atcgtcagcc gaggcagcgt gataggtgtg     1140

gtgcagatgg tcaacaaaat cagtggcagt gccttctcta aaacagatga aaacaacttc     1200

aaaatgtttg ccgtcttttg tgctttagcc ttacactgtg ctaatatgta tcatagaatt     1260

cgccactcag agtgcattta ccgggtaacg atggaaaagc tgtcctacca tagcatttgt     1320

acttcagaag agtggcaagg tctcatgcaa ttcacccttc ccgtgcgtct ctgcaaagaa     1380

attgaattat tccactttga cattggtcct tttgaaaaca tgtggcctgg aatttttgtc     1440

tacatggttc atcggtcctg tgggacatcc tgctttgagc ttgaaaagtt gtgtcgtttt     1500

attatgtctg tgaagaagaa ctatcggcgg gttccttatc acaactggaa gcatgcggtc     1560

actgtagcac actgcatgta tgccatactt cagaacaatc acacgctttt cacagacctt     1620

gagcgcaaag gactgctgat tgcgtgtctg tgtcatgacc tggaccacag gggcttcagt     1680

aacagctacc tgcagaagtt cgaccaccct ctggccgctc tctactccac ttccaccatg     1740

gagcagcacc acttctccca gactgtgtcc atcctccagt tggaagggca caatatcttc     1800

tccactctga gctccagtga atatgagcag gtgcttgaga tcatccgcaa agccatcatt     1860

gccacagacc ttgctttata ctttggaaac aggaagcagt tggaagagat gtaccagacc     1920

ggatcactaa accttaataa tcaatcacat agagaccgtg taattggttt gatgatgact     1980

gcctgtgacc tttgttctgt gacaaaactg tggcccgtta caaaattgac ggcaaatgat     2040

atatatgcag aattctgggc tgagggtgat gaaatgaaga aattgggaat acagcctatt     2100

cctatgatgg acagagacaa gaaggatgaa gtcccccaag gccagcttgg gttctacaat     2160

gccgtggcca ttccctgcta tacaaccctt acccagatcc tccctcccac ggagcctctt     2220

ctgaaagcat gcagggataa tctcagtcag tgggagaagg tgattcgagg ggaggagact     2280

gcaacctgga tttcatcccc atccgtggct cagaaggcag ctgcatctga agattgagca     2340

ctggtcaccc tgacacgctg tcccacctac agatcctcat cttgcttctt tgacattctt     2400

ttcctttttt tggggggggt ggggggaacc tgcacctggt aactggggtg caaacctctt     2460

caagaaggta acatcaaata aataagtcaa gcagaggact tcctgccaat ctcttctgtg     2520

aggcatcata gacactgagc aaccaggacc acccccacgt tcagaaatca gctggccaag     2580

tgactccatt tgacttgcaa accagccttt tctaataggc taatattgct gaggccttaa     2640

aggaaatgga caaaaattat ccagaagggg tacttttcca ttgtatcttt ctaataaggg     2700

tttaaaatgg tactattatg gtattgtact tgggctttaa catcaatgtt gctttgatgt     2760

tgttggatat aaataggaat ttttacacat tactattgtg aatggtgaat gttcatgtat     2820

gacctacttg taattaactt gagttgtagt ccacagcctc aggacaaatg tcgttgaggt     2880

tacagagtaa gaaatgatgg caaaacgtca aactcttatt tcagagcttc atgaatttag     2940

ttagactaaa cataattctt taagttcaac ctaaagggct gagatcaata aatttaacac     3000

tagacgaagt agacttcctg tctttttgag aagagatgag gtatatgtta caataaatct     3060

cagaacttca agtagcagtt caaaagatgt cagtttttaa aattgttttt gttgttgtct     3120

tggcagtttt actgaaccct ttgcataaag aacaaaataa aagctcggca ttgtaatttt     3180

tttaatggac aagtcttatg gatacgaagg gtacattttt cataatgatt cctttatatt     3240

ttcactttgt gtcattgcag aattttagac tctcattcac aatgaaaagt ttattttaaa     3300

cattgtttaa ttaaaatacc atacagttct cttttaaaca tcaaaccata aaaagtgtat     3360

tttgtaattt tactctgacc tgccgcagtc acctctcact tatctcttcc acgtactgca     3420

cggtcgtatt tcatgagctt tctgtccata gcacagaaac agagcagaaa gtagtacaat     3480

catgttggac cttctttctg ttctctttac tcttctcaca gatcagatca ctccatagaa     3540

gcctgtgggt ttcgatggtt tcttctatac acctttttgg ttgaccagta ttactataca     3600

atgtaagtgt tttaaaaaat acgaaagtaa tactctgcac cccttcctac aaagatgata     3660

aagcagtcac ttctggcgca ttttaataat ttaaagattt ttagtgcaat ggcacggtaa     3720

cctccaaacc tgaattagac agagactcac tcaggaagtg acaggcccat catatcaaat     3780

aacttattca cttttcatgt ggcaggaaac tggaatatcg cttttaataa aatggaaaaa     3840

tatgcttcta catatttacc accataggcg ttttgttcat atgagcctgg tttgtgcaaa     3900

attaaatcag aggcttctac aacatggttt atttatgttg tagcaaagtt ggctctacat     3960

aaacattgtt cttattttaa aattaacact atgtgttcag ttttcttgtg ggcttctgaa     4020

agttgccatc ttccctccgt ggagctccat ttgctatttt cattatacac tatgaggtaa     4080

aatgtaataa caaaagagag agaagtacca ctgtggctag atatatacac acacatatat     4140

atatggatgg atgtaatata tgtagaacac acacatagat gtatatagga tacacactca     4200

tgtatgtaaa cgtatacata tgtgtatata tgatacatac acatacacac acacgagaga     4260

cagaaggaaa gagaggaaga gagaagcaaa catgtaggaa aaaatataaa tcagccccat     4320

tctcccattc tttaagaaca atgatttttc ttgatggaaa atgcatatca cttgacagtt     4380

gacaagaaag tgtcattttt gtgttagtgt atcatataat tgaatttgaa caagatacat     4440

atttttctgc atacaaattt atgaagctgg agtctaccaa acacagcttt agtcacaaaa     4500

gttagtttag ttatctcatt tcgcttggag atggaatttc aggaagggat atattattta     4560

agattattgt ttaattacaa gaattttaaa agaatgtatg aattctgttt tttaatatag     4620

aaaataatta tggagttagg aatctcatgg ctacatttac atttttaggt tattacagaa     4680

aattctctta atttattata gtcaagtgta ttatgtaatc tctatttaga acagtttccc     4740

aaaggaatgt gattggattt actggttggt taatttcttg tgaaatattg tcataataga     4800

agcacagctt gaacaaaaga ctgaattctg atataaactg tcaatattgc ttttaccatg     4860

tgtaagattt acttagtaat cacagattta cctaaaataa aaggacccgg gttgcagtga     4920

tatttagtta atgatttgtt ttggaaaaca tgcagttagg agtatttttg tattttgtca     4980

gatgtttagg agacagactt tcgggtcatg tttcttgtct tgttcccaga tcttttctta     5040

aaagaacagt gtgacaccag aagccaagag atggttttta ctaacaacag ctttgatgag     5100

ttcctattaa ggtcgtattg tgtattgtgc caaattttcc acccagtata aatttagtaa     5160

cccgctatga gcatatgtag gatattcaat ttgcagatac ttttgttggt tatgttggtt     5220

tataatagac aagttttatg gtcatatgca attattccat tatctttttg gacacagtga     5280

atatgttttt tagctaaaaa tgtccttgga aacataaatg cctgccaata acatggaata     5340

ttgaattcgg gcaatgtgaa ttgattaatt agaaaagggt caaaagaaat acaatggatg     5400

tggaaactaa ttctaaaaaa tagccctatt aatagggcag agactctggt ccatttccca     5460

gctgtacttc tctctaagag gtgtatgaaa aacccatctt gcaaaagaga ccaaaatatt     5520

agacacaatc gttcccattc ctgactcttc aatggaaaag gaaggtacag atgtttacag     5580

tggtgcccca ggtgactcgt tctcaccaca acaaaagcaa ctaattggaa actagatgtg     5640

ttcaataata gatttcctct tttttggcat gctttttaga ttttttttca ttttgtaaaa     5700

tctcagttaa tttttcttta ttggtatatt tgtgtatgcg agacaaatcc tgtattgtac     5760

aggatataaa tagatgcata aatccttaga tacctgggtt ttttaatagg tttaggtttg     5820

ggtattgtgt ttctggtctt ttaactcaaa attaaggttt gagctttaat aggactaaat     5880

tattcacctg ccttggcctg tgcctttatt ttaaatactg caattttact tcttcattca     5940

tgtatttatt attttgcttt tcttgcttaa gtataattga aaatatttgc aggaacgcac     6000

aattcatttt atcaagttga atgaatagga ccattctctc ctcatcagat ttctgttctt     6060

tatttgactt cattgacata taccctggtg actataacca gtgaactgtt cagagtcagt     6120

cttttcggca agaacttcag agaactgtga cactggttat gatgtgattt tggggggttt     6180

caggtaccta agcatgattt ttaaaatcac ttctctcttt acatatttcg aacatatgtt     6240

tgctttctac actttgcaga ttttatttag gatttaattc tttaaagact atattcattt     6300

agtcactata gtggatctct tctactgcaa gtattcatct gatttttaaa ttatgtaaaa     6360

tgtaaatcag ccaagtatgt catccgttat agtttcccca tgctttcagc gcatggccat     6420

gagattttta catgtgcata agtatttagc caatacacat tttgctgact tctttaacca     6480

tttatattgt ttaaattagt aatatccaat gcagtgcaca cttttttgtc ttttttccaa     6540

cggaatattt tggttgtctg tagcgttgga agcattttat atgataaaaa tagcaagaaa     6600

aaattaaaaa gtgtcaacgg tgtgctggtt ctaaattaag aagatagaac aaagagaaag     6660

acattaatgt tacctaagaa acacatttaa catccgaaga agcaatgctg tcctcacttg     6720

atgtttctct tctcaaccca gcaatggaga gcagggcttg caaagccgta cagagcctac     6780

gtgctctttc ctgcaagtgg gagaaaacta atcaatggca cacagggcca ggtgtggccc     6840

tgtgaggcaa aggataatgt cacctcagga ccaaggtgga aacttacagc tgaatccagg     6900

gcttactaag tagggaagtc agtttacata tttcagtttt cctctgatgt ttttgaggta     6960

ctgtgtattt gcagaagttt aagcagaagg gttttgtttc tattgtaagt taggttctaa     7020

aagtgtataa tctgatactc tagcccaact gaaatattat atcttgggcg ttacagcctt     7080

tgtctttttc tttagtcacc ttaataccca gtcctatgct gtatctctga tagcctatat     7140

aaatgacata taggaatatt attttccata tgatctgttg tatggtgtat atgctatgtg     7200

ttcatttcgt gtgcaagttc agagtgtaat agatttaccc agagaaggtg tttctataca     7260

atgcccctac ctatttgaaa ttacatgctt gcccaacaca ctgtgaaata gttaccaaaa     7320

tttgtacaaa tgcagcatct tcattctttc tgagaagaca agatggtttt ctttacatga     7380

acaaatgaac aaaagagatc ctagatccat aacgtagcta aggcatctaa gagtttgctg     7440

ttgataatct tgctgaccaa aaactactgg agagtaacac aggttatatg ccatcacaaa     7500

tacaatgctc atgaagaact gatttgtaga gtcaatgaac ctgtgtccag aattttaata     7560

ggctctctat tggaaggaga aagaatttca agttaacagt atctaacttt atcatagttg     7620

atgttagtaa attttaaaaa atgattttat atgtatgaca aaaatctttg taaaatgcgc     7680

aagtgcaata atttaaagag gtcttaactt tgcatttata aattataaat attgtacatg     7740

tgtgtaattt tttcatgtat tcatttgcag tctttgtatt taaaaaacat ttactgttat     7800

gtttgtataa tagaacagta atcatttatt ataatctagg caagttgtaa ataaattcat     7860

aattcaaaca gccagtatat atgcatatat gagtgttata ttgcaaaatc tttgttttac     7920

ttacatggtt aaagcagcaa gaattctttt gttgatatgt aattatacac ataaaatata     7980

tatatgtatg atacatgaaa tatatttaga aatgttcata attttaatgg atatcctttg     8040

gtgtgaataa ttgaatacag agtttttaaa ata                                  8073


<210> 2257
<211> 1767
<212> DNA
<213> Homo sapiens

<400> 2257
tccatcatgt ggccactgac agcccttctg ctcctggttc caagcagtgg gcaagctgct       60

actctggaga agcccatatt gtctctacat ccaccttgga ccaccatctt caaaggggag      120

cgggtaactt tgaagtgtga tggataccac ccactgctcc tggagctcca gcccatcagc      180

actctctggt atttgggcca cctacttctg ccctctcaca agaagagcat tgaggtgcag      240

acaccagggg tgtatcgatg ccagacacgg ggagcacccg tcagtgaccc catccacctc      300

tctgtatcca atgattggct gattctgcaa gtgccctatg cgccagtgtt cgagggtgag      360

ccgctagtcc tgcgctgccg cggctggtac gacaaggtgg tctacaagct tcactactac      420

cacgacggcc aggccgtgcg ctacttccac tccagcgcca actacactgt gttacaggcg      480

cgtgccagcg acagcgggcg ctaccagtgc tcgggcacca tgcgcatccc ggtggagagc      540

gcgcccatgt tctccgctaa ggtggctgtg acagtgcaag agctgttccg ggcgccggtg      600

ctgagggtga tgggtccgcg ggaggcccgc ggcgcggcgc tgggtggggt ggtgctgcgc      660

tgcgacacgc gcctgcaccc gcagaagcgc gacacgccgc tgcagttcgc gttttacaag      720

tacagccgcg cggtgcgccg cttcgactgg ggcgccgagt acacagtccc ggagcccgag      780

gtcgaggagc tcgaatcgta ctggtgcgag gcggctaccg ccacccgcag tgtccggaaa      840

cgcagtccgt ggctgcagct cccggggccg ggttctcccc tggacccggc ctccaccacc      900

gccccagctc catgggccgc agccttggct cctggtaata ggccgctttc cttcagaaag      960

cccccggtgt ccagatcggt cccgttggtc acctccgtcc ggaacaccac ctccaccggg     1020

ctgcagttcc cggcgagcgg cgccccgact gcggggccac ccgcctgcgc tccgccgacg     1080

cccttggaac aatcggctgg agccctgaaa cccgacgtgg accttctgct ccgagaaatg     1140

cagctgctca aaggccttct gagccgggtg gtcctggaat taaaggagcc acaggccctc     1200

cgggagctca ggggaacgcc cgagaccccc acctctcact ttgctgtgag cccgggaacc     1260

ccagagacca ctcctgtgga gagctgaggg ggcggctacc gtcccctctg caggctcatt     1320

cctccttggt ctcctgcttc ccctcacgcg aatttctttc aaagccatct gtttgcatcc     1380

ttgtgttttg ctgtggtttt taaaggagcg cccacgaagt gtagtggctg acgatttcaa     1440

cctcacacag cagtttgtaa ccgcaagcat tctctttgaa ttctcacaga attcagcaag     1500

aagtagaaac ctgttattta ctacattgtg atttaacttt ggatgtgaat ttagtcaccc     1560

ttagcccttc agataagcct agccagtaca tatttcagca caggcagttt ttttggtatt     1620

taagtacatt gaggtaactg agcacttgag aatattttag ggtcaaagtg taattattca     1680

taatgaattt actctgttga tattaaaaag acgttcagtc ctattactga tgagtttaca     1740

tcttcaaata aatcctgggt tctattt                                         1767


<210> 2258
<211> 2005
<212> DNA
<213> Homo sapiens

<400> 2258
acagttccat ccattctagg gatcagtgtc tttcaatgat gtgactgtgg acttcactca       60

ggaggagtgg cagcacctgg atcatgctca gaagactcta tatatggatg tgatgttgga      120

aaactattgc cacctcatct ctgtggggtg tcacatgacc aaacctgatg tgatcctcaa      180

gttggaacga ggagaagagc catggacatc atttgcaggt catacctgct tggaagaaaa      240

ctggaaagct gaagactttt tagtgaaatt caaggaacac caagagaagt attctagatc      300

agttgtaagc atcaaccaca aaaaactggt gaaggagaag agtaaaatat atgaaaagac      360

atttactcta ggcaaaaacc ctgtgaattc aaaaaatcta cctcctgaat atgatactca      420

tggaaggatt ttgaaaaatg tttcagaatt aatcatcagt aatctaaatc ctgcaagaaa      480

gagacttagt gagtataatg gatatgggaa atcactcctg agtactaaac aagagactac      540

tcatcctgaa gtcaaatccc ataatcaaag tgccagagct ttcagtcata atgaagttct      600

tatgcagtat cagaaaacgg aaactccagc acagtcattt ggatataatg actgtgagaa      660

atcattcctt caaaggggag gcctgattac acatagtaga ccttacaaag gagaaaaccc      720

atctgtatat aataaaaaaa gaagagcaac caatattgaa aaaaaacata catgcaatga      780

atgtgggaaa tctttctgca ggaaatcagt attgattctg catcagggaa ttcactcaga      840

agaaaaaccc tatcaatgtc atcaatgtgg aaatgcattt agaaggaaat catatctcat      900

tgatcatcag agaactcaca caggagagaa accctttgtt tgcaatgaat gtggtaagtc      960

cttccgcctc aagacagccc tcactgatca tcagagaaca cacacagggg agaaatcgta     1020

tgaatgtctg caatgtagga atgccttcag attgaagtca cacctcattc gtcatcagag     1080

aactcacacg ggagagaaac catatgagtg taatgactgt gggaagtcct tccgccagaa     1140

gacaacactc tctctacatc agagaatcca tacaggtgag aaaccctaca tttgtaaaga     1200

atgtgggaag tcctttcacc agaaggcaaa tcttactgta catcagagaa ctcatacagg     1260

ggaaaagccc tatatttgta atgaatgtgg gaaatccttc tcccagaaga caacccttgc     1320

tcttcatgag aaaactcata atgaggagaa accctatatt tgtagtgaat gtggaaagtc     1380

cttccgccag aagacaaccc ttgtagcaca tcagagaaca catacagggg agaaatctta     1440

tgaatgtcct cactgtggga aggcctttag aatgaagtca tacctcattg atcatcaccg     1500

aactcacaca ggagagaaac catatgaatg taatgaatgt ggtaaatcat tcagtcaaaa     1560

gacaaatctc aatctacatc agagaattca tacaggggag aaaccctatg tttgtaatga     1620

atgtgggaag tcctttcgcc agaaagcaac cctcactgta catcagaaaa tacataccgg     1680

ccagaaatcc tatgaatgtc ctcagtgtgg gaaagccttt agcaggaagt catatctcat     1740

tcatcatcaa agaactcata cgggagagaa accatataaa tgtagtgaat gtggaaagtg     1800

cttccgccag aagacaaatc ttattgtaca tcagagaact cacacaggtg gagaggatgg     1860

cctaactgga tgtttatcct agcgtcaacc caccaaagat ttggggaaca tgtgagtcac     1920

attctctggg acattctact cccctttgat tttgcatttc cagacatttc agtggctacc     1980

acaaaaaata aaaagtatct gtggc                                           2005


<210> 2259
<211> 725
<212> DNA
<213> Homo sapiens

<400> 2259
ggcgcggcaa gatggaggtg acgggggtgt cggcacccac ggtgaccgtt ttcatcagca       60

gctccctcaa caccttccgc tccgagaagc gatacagccg cagcctcacc atcgctgagt      120

tcaagtgtaa actggagttg ctggtgggca gccctgcttc ctgcatggaa ctggagctgt      180

atggagttga cgacaagttc tacagcaagc tggatcaaga ggatgcgctc ctgggctcct      240

accctgtaga tgacggctgc cgcatccacg tcattgacca cagtggcgcc cgccttggtg      300

agtatgagga cgtgtcccgg gtggagaagt acacgatctc acaagaagcc tacgaccaga      360

ggcaagacac ggtccgctct ttcctgaagc gcagcaagct cggccggtac aacgaggagg      420

agcgggctca gcaggaggcc gaggccgccc agcgcctggc cgaggagaag gcccaggcca      480

gctccatccc cgtgggcagc cgctgtgagg tgcgggcggc gggacaatcc cctcgccggg      540

gcaccgtcat gtatgtaggt gcgtggctcg cgggcccggt cccgggctcc agggctccaa      600

ggccgggagg aaatgttggg ggcacagtgg agcctcggag accacgctct gcctaggggc      660

gcggggttgg gggggactcg aaacgatctc agtccctgga ggtgacggaa ccatctgccg      720

acact                                                                  725


<210> 2260
<211> 588
<212> DNA
<213> Homo sapiens

<400> 2260
cagaatttgg ctgaggaggc tggtctgaac atcactcaca tttgcctccc tccagatagc       60

agtgaagccg agattataga tgaaatctta aagatcaatg aagataccag agtacatggc      120

cttgcccttc agatctctga gaacttgttt agcaacaaag tcctcaatgc cttgaaacca      180

gaaaaagatg tggatggagt aacagacata aacctgggga agctggtgcg aggggatgcc      240

catgaatgtt ttgtttcacc tgttgccaaa gctgtaattg aacttcttga aaaatcagta      300

ggtgtcaacc tagatggaaa gaagattttg gtagtggggg cccatgggtc tttggaagct      360

gctctacaat gcctgttcca gagaaaaggg tccatgacaa tgagcatcca gtggaaaaca      420

cgccagcttc aaagcaagct tcacgaggct gacattgtgg tcctaggctc acctaagcca      480

gaagagattc cccttacttg gatacaacca ggaactactg ttctcaactg ctcccatgac      540

ttcctgtcag aaagtttgat tatcattaga agaatggcca tcttttaa                   588


<210> 2261
<211> 1943
<212> DNA
<213> Homo sapiens

<400> 2261
ctttggcctg ccatctccca agggcaaacc tcacaactca ggcccaagtc acaggaatct       60

gaatggtggg gtgaccttct cctctagttt aatttcattg caatactgag aaacttcaac      120

tgttttgtct ttagaaggga aattcatgtt tgtgccaggc cagcctttgt aaaagccttt      180

gattggattc actagaagtc tgtcttcccg cagtacatat actgtgaatt ttctccttcg      240

gcatttcaac cacttggaat ggccactaaa gtggcttttg atctaaagta aactctgatt      300

ctgtgttgat ggggaaccat ttctctctaa catggtggtt tctttaagat gtttgacttg      360

ggccacatga gaataacaga tctttgggca gtccaagcaa gagcctcctg atctagcagc      420

caagactccc cctgaccttt ggccatgtac cccaaccctc tcatctactg cacctgctgg      480

gacccctgga acttgggacc acggaagcta atcaagaccc ctcaactacc acgcaagaac      540

tccacaggga gttccaagct aactcctctt gtaccagctc caaaaaatca caattacctc      600

caaccaacaa aacctgttgt ttccccaaaa atgaaaatcc attcagcaag gcaagaagag      660

actaataaat cattttatga agtgatcaac gtgtcacctg gctatcaact tgttcggaat      720

cgggaacaga tttctgtcac cttaggggat gagatgtttg ataggaaaaa gcggtgggaa      780

tcggagatcc cggacaaagg cagattttcc aggaccaaca tcatttctga cctagaagag      840

caaatctcag agctgacagc aataattgaa caaatgaaca gagaccacca gtctgcccag      900

aaattgctct ccagtgaaat ggatctccgc tgtgctgaga tgaaacagaa ctttgaaaac      960

aagaacaggg agctcaaaga ggcccatgaa gcagaactca gtgagttgga gaacaactac     1020

aaagcagcct tgaaggcaga gaagttggct gcccaagaga agctagagga gatgggaaaa     1080

gaatacaagt atttgaagaa tatgtttcgt acgtatcagg acagtattta tgatgaaatg     1140

gaagagaagt ggtcaaaaca gaaggcgaaa tggaagaagg atgagaagtt cgagcgagaa     1200

aatatcctgc tacagcaaaa aaaaaagatg accaaaaaat tcgaaatgga gtcaggagaa     1260

gaagataaga aaataaatga atcctgcagt gctgtctttg agaacttcat tcaagagaag     1320

gaggagctct tgaaacaaca tcaaagtgac accttgcaat tagaagagct gagaaaaacc     1380

aaagaggtca tgcaggaaga attgcatgca caagccctta tcctagagtc actgaacaca     1440

aacctctact atacccagtt ggaactccag aaagagaaag ctatagtggg aaatctggag     1500

aaaatgcttc aaaccaagtt tgctgaaact gaagaaaagt ataagcacac catacagatc     1560

ctgacggaag agaacattca tctgaagcaa aagataattt ctaagaatga agaaatttgt     1620

gaaggatgtt ctgggagatt ggcctctatt actgtttcta aggatgattc tgacactgtg     1680

caagatggta gcaagaaagg acaagaatca taaacaaaaa gttgctctgc attgttgaag     1740

atggttggca caccatttct gtaggcccag gaaactcctg ggagggtttt cttgagaaaa     1800

tgcatataat gagtttagtt cttgggttgc tctgactctc tgaatgtctg aaaatgtttg     1860

aattcgcatc tgaatttcac agcttatcac ggactcttca ctgaaaaatg atgctctcca     1920

tactgggagc tgagctttct ctg                                             1943


<210> 2262
<211> 2540
<212> DNA
<213> Homo sapiens

<400> 2262
gcggccgcca cgcgacgcct ggctgggccc gcaccggaga ggcgtctcgg tacctggcag       60

gcggcctgct actcggagcc cgctgcgggg cggcggcggc ggggacatgc acgtgtgaga      120

tgcggcagcg ggcggcgcgg acgcgaacag cagcggcggc ggcgggcgcg gcctcctggg      180

cgcggggcgc gcggtgcctg agggcgggcg cgcgggcgct gggcaactgc cggccgcgcc      240

gcctgcgcag gcgctggttc aggactcaca cgccgcgctg aggcccgcgg gcccgtcatg      300

gaggcgccca ccgtggagac gccccccgac ccctcgcccc cttcggcccc ggcccctgcc      360

ctggttccgt tgcgcgcccc ggatgtggcg cggctgcgcg aggagcagga aaaggtggtc      420

actaactgcc aagagagaat ccagcattgg aagaaggtag ataatgacta taatgccctt      480

cgagaaagac tcagcacctt gcctgataaa ttgtcttata atataatggt accatttggc      540

ccttttgcct tcatgccagg aaaacttgtc catactaatg aagtcactgt tttactgggg      600

gacaactggt ttgcaaagtg ctcagcaaag caggctgtag gtttagttga gcaccggaaa      660

gaacatgtaa gaaaaacaat agatgactta aaaaaagtga tgaaaaattt tgaatccaga      720

gttgaattca cagaagattt gcagaaaatg agcgatgctg caggtgatat tgttgacata      780

cgagaagaaa ttaaatgtga cttcgaattt aaagcaaaac accgaattgc tcataaaccg      840

cattccaaac caaaaacttc agatattttt gaagcagata ttgcaaatga tgtgaaatcc      900

aaggatttgc tagctgataa agaactgtgg gctcgacttg aagaactaga gagacaggaa      960

gaattgctgg gtgaacttga tagtaagcct gatactgtga ttgcaaatgg agaagatacg     1020

acatcttctg aagaggaaaa ggaagatcgt aacacaaatg tgaatgcgat gcatcaagta     1080

acagactctc atactccttg tcataaggat gttgcaagtt cagaaccatt cagtggtcaa     1140

gtgaatagtc agttgaactg ttcagtgaat ggttccagtt cttaccacag tgatgatgat     1200

gatgatgatg atgatgacga cgacgacgac aacattgacg acgatgatgg tgataacgac     1260

catgaggctt taggggttgg agataattct ataccaacaa tatatttttc acatactgtt     1320

gagcctaaga gggtccgaat aaatactgga aagaatacca ctttaaaatt cagtgaaaag     1380

aaagaagaag ccaaacgtaa acgaaagaac agcactggca gtggccactc tgcccaggag     1440

ctgccgacca tcaggacgcc tgcagacatt tacagagcct ttgttgatgt tgtgaatgga     1500

gaatatgtcc ctcgcaaatc catcctgaag tctcgaagta gagagaatag tgtgtgtagc     1560

gacactagtg aaagcagtgc tgctgaattt gatgataggc ggggagtttt gaggagtatc     1620

agctgcgaag aagccacttg cagtgacacc agtgagagca ttttggaaga ggaaccacaa     1680

gaaaatcaaa agaaactttt gcccttatca gtaacacctg aggctttttc tggaactgtt     1740

atagaaaaag aatttgtatc accttcctta acaccacccc cagccattgc tcatcccgca     1800

ctacccacta ttccagaacg aaaggaagtt ctgttggaag catctgaaga aactggaaag     1860

agggtttcaa agtttaaagc tgccagattg caacagaaag actaggccct gtctaggaaa     1920

tgggaattta catcctaaaa cctagttgtt catttgttta gagtatctat agcaaaatag     1980

gttacatgta gtttgaaata aggtatcctg agttactttg gcaacaagtt cttttaccct     2040

tacccgtggt atttgaaaaa aatcaaggta actgtctgaa tactttaata tcagcttgtt     2100

ttgtgaattc tctgaatact gtcaacactc ttatctaagt ttgcctttat gatgcagtgg     2160

cagcattttg aattactttt caaagaatac tgttcatatg cattgttttt gtgtttcaaa     2220

ctaaatacag gcagttttgt gccagctgtg atattgtgca taccatatgg accattttaa     2280

agaaaatttt aaaatttcaa atagattcaa caattacatt acttgctttc acattttaaa     2340

ggcactttaa aaaaatctac ttctcttgta ggttttgcgg ctagttggct attcaagaaa     2400

cctcgcccct ctgaatgtca tactgtaatc tttaaggaag aaagctacat gaattaattg     2460

tactctatgg gaaaatttct ttggaaagat attttgtaaa actttttttt ccaagtaaaa     2520

actttatgaa acttggtctc                                                 2540


<210> 2263
<211> 1180
<212> DNA
<213> Homo sapiens

<400> 2263
gtataaaaga ccgagctggg ggggcggcgg caggtctctg cgcagcccag cccgccggtc       60

cacgccgcgc accgctccga gggccagcgc cacccgctcc gcagccggca ccatgcgcga      120

gatcgtgcac atccaggcgg gccagtgcgg caaccagatc ggcgccaagt tttgggaggt      180

catcagcgat gagcatggga tcgaccccac aggcagttac catggagaca gtgacttgca      240

gctgctgacc cactctctgg ggggcggcac ggggtccggg atgggcaccc tgctcatcag      300

caagatccgg gaagagtacc cagaccgcat catgaacacc ttcagcgtca tgccctcacc      360

caaggtgtca gacacggtgg tggagcccta caacgccacc ctctctgtcc accagctggt      420

ggaaaacaca gatgaaacct actccattga taacgaggcc ctgtatgaca tctgcttccg      480

caccctgaag ctgaccaccc ccacctacgg ggacctcaac cacctggtgt cggccaccat      540

gagcggggtc accacctgcc tgcgcttccc gggccagctg aacgcagacc tgcgcaagct      600

ggcggtgaac atggtgccct tccctcgcct gcacttcttc atgcccggct tcgcgcccct      660

gaccagccgg ggcagccagc agtaccgggc gctcacggtg cccgagctca cccagcagat      720

gttcgactcc aagaacatga tggccgcctg cgacccgcgc cacggccgct acctgacggt      780

ggctgccatc ttccggggcc gcatgtccat gaaggaggtg gacgagcaga tgctcaacgt      840

gcagaacaag aacagcagct acttcgtgga gtggatcccc aacaacgtga agacggccgt      900

gtgcgacatc ccgccccgcg gcctgaagat gtcggccacc ttcatcggca acagcacggc      960

catccaggag ctgttcaagc gcatctccga gcagttcacg gccatgttcc ggcgcaaggc     1020

cttcctgcac tggtacacgg gcgagggcat ggacgagatg gagttcaccg aggccgagag     1080

caacatgaac gacctggtgt ccgagtacca gcagtaccag gacgccacgg ccgacgaaca     1140

aggggagttc gaggaggagg agggcgagga cgaggcttaa                           1180


<210> 2264
<211> 916
<212> DNA
<213> Homo sapiens

<400> 2264
gatcggccag ggctgggggc gctgggggcg ctacgggcgc ggcgggtgcc tgggagctgc       60

tgggagtcct tgtttccgct cccgcccagg actgtgcgct cggctcgcgg tggggtccgg      120

cgggcgcggc ttcggcgggc ggcagccgct gcagacgagc tgcggagacg gagtttcgtc      180

atgttggcca ggcccatttg agatctttga agatatcctc aacgtgaggc tctgctgcca      240

tgaaggtgaa gattaagtgc tggaacggcg tggccacttg gctctgggtg gccaacgatg      300

agaactgtgg catctgcagg atggcattta acggatgctg ccctgactgc aaggtgcccg      360

gcgacgactg cccgctggtg tggggccagt gctcccactg cttccacatg cattgcatcc      420

tcaagtggct gcacgcacag caggtgcagc agcactgccc catgtgccgc caggaatgga      480

agttcaagga gtgaggcccg acctggctct cgctggaggg gcatcctgag actccttcct      540

catgctggcg ccgatggctg ctggggacag cgcccctgag ctgcaacaag gtggaaacaa      600

gggctggagc tgcgtttgtt ttgccatcac tatgttgaca cttttatcca ataagtgaaa      660

actcattaaa ctactcaaat cttgctggag gcctctgggt gcctgtgttc tcggcatata      720

gatgtggtct cggtgtgttt tgatatgaaa actctcatga ataaacatct ccgtgaaacg      780

ccaaggccct cgtcaaaccc tgagtcatga ctgggaggag aaggagcagg atcagacggt      840

agagcctggg gcatgctctt caggcatgct cttgcctgct ggattgccgg cggcggccct      900

gggaccctcc ctcagg                                                      916


<210> 2265
<211> 3528
<212> DNA
<213> Homo sapiens

<400> 2265
gatgtgatag ctctatggaa gtccaaactg gagactgcca tcgcatccca ccagcaggcg       60

atggaagaac tgaaggtatc tttcagcaaa gggcttggaa cagagacggc agaatttgct      120

gaactaaaaa cacaaataga gaaaatgaga ctagattacc aacacgaaat agaaaatttg      180

cagaatcaac aagactctga acgggctgcc catgctaaag agatggaagc cttgagggct      240

aaactgatga aagttattaa agaaaaggaa aacagtctgg aagccatcag gtcgaaactg      300

gacaaagcag aagaccagca tctcgtagaa atggaagaca cgttaaacaa attacaggaa      360

gctgaaataa agaaagaaaa gtttgctgaa gcttcagagg aggcagtctc tgttcagaga      420

agtatgcaag aaactgtaaa taagttacac caaaaggagg aacagtttaa catgctgtct      480

tctgacttgg agaagctgag agaaaactta gcagatatgg aggcaaaatt tagagagaaa      540

gatgagagag aagagcagct gataaaggca aaggaaaaac tggaaaatga cattgcagaa      600

ataatgaaga tgtcaggaga taactcttct cagctgacaa aaatgaacga tgaattacgt      660

ctgaaagaaa gagatgtaga agaattacag ctaaaactta caaaggctaa tgaaaatgca      720

agttttctgc aaaagtattg aggacatgac tgtcaaagct gaacagagcc agcaagaagc      780

agctaaaaag catgaggaag aaaagaaaga attggagagg aaattgtcgg acctggaaaa      840

gaaaatggaa acaagccaca accagtgtca ggagctgaaa gccaggtatg agagagccac      900

ttctgagaca aaaaccaagc atgaagaaat cctacagaac ctccagaaga cgctgctgga      960

cacagaggac aagctgaagg gcgcacggga ggagaacagt ggcttgctgc aggagctgga     1020

ggagctgaga aagcaagccg acaaagccaa agctgctcaa acagcggaag atgccatgca     1080

gataatggaa cagatgacca aagagaagac tgagactctg gcctccttgg aggacaccaa     1140

gcaaacaaat gcaaaactac agaatgaatt ggacacactt aaagaaaaca acttgaaaaa     1200

tgtggaagag ctgaacaaat caaaagaact cctgactgta gagaatcaaa aaatggaaga     1260

atttaggaaa gaaatagaaa ccctaaagca ggcagcagct cagaagtccc agcagctttc     1320

agcgttgcaa gaagagaacg ttaaacttgc tgaggagctg gggagaagca gggacgaagt     1380

cacaagtcat caaaagctgg aagaagaaag atctgtgctc aataatcagt tgttagaaat     1440

gaaaaaaaga gaatccaagt tcataaaaga cgcagatgaa gagaaagctt ccttgcagaa     1500

atccatcagt ataactagtg ccttactcac agaaaaggat gccgagctgg agaaactgag     1560

aaatgaggtc acagtgctca ggggagaaaa cgcctctgcc aagtccttgc attcagttgt     1620

tcagactcta gagtctgata aggtgaagct cgagctcaag gtaaagaact tggagcttca     1680

actcaaagaa aacaagaggc agctcagcag ctcctcaggt aatacagaca ctcaggcaga     1740

cgaggatgaa agagcccagg agagtcaggt aatgattgat ttcctaaatt cagtaatagt     1800

ggaccttcaa aggaagaatc aagacctcaa gatgaaggtg gagatgatgt cagaagcagc     1860

cctgaatggg aacggggatg acctaaacaa ttatgacagt gatgatcagg agaaacagtc     1920

caagaagaaa cctcgcctct tctgtgacat ttgtgactgc tttgatctcc acgacacaga     1980

ggattgtcct acccaggcac agatgtcaga ggaccctccc cattccacac accatggcag     2040

tcggggtgag gaacgcccat actgtgaaat ctgtgagatg tttggacact gggccaccaa     2100

ctgcaatgac gacgaaacct tctgatgaag cctccagtgg agaactgggc ttgctcagac     2160

gcactcgcat tgacacaacg taacaccagc attgtgtgtg cagacttcag gagaactcat     2220

gttatttttt aaccccgtca acaaatctag gaaaatattt tgatcttcaa caaattgccc     2280

tttagtctcc ccgtatgagt tagaataata aatatttagt aggtgagttt tcacctcgaa     2340

ttttgttttc ttgattttta cgtttgaaga cattgcacca gatgccatta catttattgg     2400

ccccccgacc ttgtagaaaa acccctaccc tcacaatacc ttatttaagt aactttaaat     2460

tatgccgtta cttttcatat ttgcactaag atatttccag gctgcatttg tatatttaga     2520

ttttttggtt aagctttgac actggaatga gttgaaaaaa tgtgccattt tgcattttca     2580

tctactcatt taaagtattt tattcttatt caaagaaata tctgagctct ttgcactacc     2640

tgttatcagt agtgccttta cttcaggctt gataatactt aggtgtgatt ataaaatcat     2700

gaagcaggta aagggagggg caagccccca aactgctgtg gggacatttt ataatctata     2760

tgctgcaccc acttaatcta ctgtggtgtt ttgtttatta gttttgcata atttcagctt     2820

ctatatattg tatgtatata ttttttaaaa atctatattt tgggaaaaaa acatacacaa     2880

tgtgtctttc tttttggaca tttacctttt tgaaaaagaa aacacttaaa atgatcatta     2940

ggacataaca gactaggcca gacatagcat cttgtggctt tgcaaccatt ttcatttgtt     3000

tgttttcctt ttatttcttc accagattta aataactgga ggaattttct ccaatttttt     3060

tttccttctc tggcaggtat ccccagcagt caattaacaa taagccagta taaaacacct     3120

aaataaccaa tctacaatct cccttcacaa gtttttttac tgtttttaga tgaatgtacg     3180

atgagaaatt caacgttaat aattctggat tttcttatca caaaaaagaa aatgaaggac     3240

ctcaaagcac ctgaacagtt tatcgaccag tttgaatcta tttatcttca tttgaatgtc     3300

ttctagaata tgtaaaaagt cataaaatgt atcttccatg ctacatgtac aataagaact     3360

tctataattg tatatatgcc tttgatgtat tttcccctca agattatcaa ctgtgtgttc     3420

gacagtgaat attcaatctg gtaccagttg aaatttttgg ttataaatgt aatacgaatt     3480

gtttcacaaa cagaaaacat gtaaagcagt attaaaattt ggccaaac                  3528


<210> 2266
<211> 2967
<212> DNA
<213> Homo sapiens

<400> 2266
gagcctgggg aggtcgaggg tgcagcgagc cgtgatcgtg ctactgcact ccagcctggg       60

caacacagag agaccctgtc tcaaaacaaa caaacaaaca aacaaacaaa caaacaaaaa      120

aaacaaagaa aaaaaaatgg gagtgggccg ggcgcggtga ctcacacctg taatcccagc      180

actttcggag gccaaggcgg gtggatcacg aggtcaggaa ttcaagatta gcctggacaa      240

catggtgaaa ccccatctct acgaaaaata caaaaattag ccaagtatgg tggccggcgc      300

ctgtaatccc agctactcgg gagactgagg cagagaactg cttgaacctg ggaggcagag      360

gttgcagtga tccgagatcg cgtcactgca ctccagcgtg ggcgacagag cgagactccg      420

tttcagaaaa gaaaaaaaaa aaaaaaaaaa agggagtcgg ggtggagctc tcattggctc      480

gttgcatgtg agtgtcccta cggcctagaa atacaagaga agcacatcgg aacgggctgg      540

aaatccaccc agttaactag agggctttga accttttatt aacttggagg ttgactctcc      600

tgtcaactcg attccctttt ggctgtttgg cagggtcagt gagacatccc ctgggtcgct      660

cgaccccgta ggacggttca gggagccctc caggtcttcg tttctcctct tccccgcaca      720

gtgctgttat ccagctgggg gatccaacgc acacttaagg ctccagcaaa gtggctccgc      780

tgccggatgg gagtgcccca gtgtgctgga tgaagctggc gcatgcacca tgtcatcatg      840

tgtctctagc cagcccagca gcaaccgggc cgccccccag gatgagctgg ggggcagggg      900

cagcagcagc agcgaaagcc agaagccctg tgaggccctg cggggcctct catccttgag      960

catccacctg ggcatggagt ccttcattgt ggtcaccgag tgtgagccgg gctgtgctgt     1020

ggacctcggc ttggcgcggg accggcccct ggaggccgat ggccaagagg tcccccttga     1080

cacctccggg tcccaggccc ggccccacct ctccggtcgc aagctgtctc tgcaagagcg     1140

gtcccagggt gggctggcag ccggtggcag cctggacatg aacggacgct gcatctgccc     1200

gtccctgccc tactcacccg tcagctcccc gcagtcctcg cctcggctgc cccggcggcc     1260

gacagtggag tctcaccacg tctccatcac gggtatgcag gactgtgtgc agctgaatca     1320

gtataccctg aaggatgaaa ttggaaaggg ctcctatggt gtcgtcaagt tggcctacaa     1380

tgaaaatgac aatacctact atgcaatgaa ggtgctgtcc aaaaagaagc tgatccggca     1440

ggccggcttt ccacgtcgcc ctccaccccg aggcacccgg ccagctcctg gaggctgcat     1500

ccagcccagg ggccccattg agcaggtgta ccaggaaatt gccatcctca agaagctgga     1560

ccaccccaat gtggtgaagc tggtggaggt cctggatgac cccaatgagg accatctgta     1620

catggtgttc gaactggtca accaagggcc cgtgatggaa gtgcccaccc tcaaaccact     1680

ctctgaagac caggcccgtt tctacttcca ggatctgatc aaaggcatcg agtacttaca     1740

ctaccagaag atcatccacc gtgacatcaa accttccaac ctcctggtcg gagaagatgg     1800

gcacatcaag atcgctgact ttggtgtgag caatgaattc aagggcagtg acgcgctcct     1860

ctccaacacc gtgggcacgc ccgccttcat ggcacccgag tcgctctctg agacccgcaa     1920

gatcttctct gggaaggcct tggatgtttg ggccatgggt gtgacactat actgctttgt     1980

ctttggccag tgcccattca tggacgagcg gatcatgtgt ttacacagta agatcaagag     2040

tcaggccctg gaatttccag accagcccga catagctgag gacttgaagg acctgatcac     2100

ccgtatgctg gacaagaacc ccgagtcgag gatcgtggtg ccggaaatca agctgcaccc     2160

ctgggtcacg aggcatgggg cggagccgtt gccgtcggag gatgagaact gcacgctggt     2220

cgaagtgact gaagaggagg tcgagaactc agtcaaacac attcccagct tggcaaccgt     2280

gatcctggtg aagaccatga tacgtaaacg ctcctttggg aacccattcg agggcagccg     2340

gcgggaggaa cgctcactgt cagcgcctgg aaacttgctc accaaaaaac caaccaggga     2400

atgtgagtcc ctgtctgagc tcaagaccta gaaaataagt ccccttcctg cctgttgcaa     2460

agtaacgtaa gagttccctc acccgagtgg atgcagacct tcttgctgtc agccaccctt     2520

ccttcataca catagccagc ccaggtgacc agaacctccc aggacagatg aggctttgtg     2580

tccttatgag actgggagaa cctgctgggc acccctgctg caggtgctgt ggtgggtggg     2640

gaccccactg cccttcccac tgagcacatc atggctacct gacttggtgg gagctccagg     2700

cagtcacttc tgtttcttaa acatagcttt actgaggtac aattcacata ccatgtaatt     2760

cacccacggg aagtgtatga ttcagtggtt tctaatacag acttctgcag ccattaccac     2820

cgtcaacttt acgacatttt catcagccca agaagacacc ctacactcct tagctgtccc     2880

catccaactc ccccacccca gtaaccactc agaataggta tggatttgcc tattctggac     2940

gtttcgtata aatggcgtca tacacta                                         2967


<210> 2267
<211> 4450
<212> DNA
<213> Homo sapiens

<400> 2267
gcaccatgtc atcatgtgtc tctagccagc ccagcagcaa ccgggccgcc ccccaggatg       60

agctgggggg caggggcagc agcagcagcg aaagccagaa gccctgtgag gccctgcggg      120

gcctctcatc cttgagcatc cacctgggca tggagtcctt cattgtggtc accgagtgtg      180

agccgggctg tgctgtggac ctcggcttgg cgcgggaccg gcccctggag gccgatggcc      240

aagaggtccc ccttgacacc tccgggtccc aggcccggcc ccacctctcc ggtcgcaagc      300

tgtctctgca agagcggtcc cagggtgggc tggcagccgg tggcagcctg gacatgaacg      360

gacgctgcat ctgcccgtcc ctgccctact cacccgtcag ctccccgcag tcctcgcctc      420

ggctgccccg gcggccgaca gtggagtctc accacgtctc catcacgggt atgcaggact      480

gtgtgcagct gaatcagtat accctgaagg atgaaattgg aaagggctcc tatggtgtcg      540

tcaagttggc ctacaatgaa aatgacaata cctactatgc aatgaaggtg ctgtccaaaa      600

agaagctgat ccggcaggcc ggctttccac gtcgccctcc accccgaggc acccggccag      660

ctcctggagg ctgcatccag cccaggggcc ccattgagca ggtgtaccag gaaattgcca      720

tcctcaagaa gctggaccac cccaatgtgg tgaagctggt ggaggtcctg gatgacccca      780

atgaggacca tctgtacatg gtgttcgaac tggtcaacca agggcccgtg atggaagtgc      840

ccaccctcaa accactctct gaagaccagg cccgtttcta cttccaggat ctgatcaaag      900

gcatcgagta cttacactac cagaagatca tccaccgtga catcaaacct tccaacctcc      960

tggtcggaga agatgggcac atcaagatcg ctgactttgg tgtgagcaat gaattcaagg     1020

gcagtgacgc gctcctctcc aacaccgtgg gcacgcccgc cttcatggca cccgagtcgc     1080

tctctgagac ccgcaagatc ttctctggga aggccttgga tgtttgggcc atgggtgtga     1140

cactatactg ctttgtcttt ggccagtgcc cattcatgga cgagcggatc atgtgtttac     1200

acagtaagat caagagtcag gccctggaat ttccagacca gcccgacata gctgaggact     1260

tgaaggacct gatcacccgt atgctggaca agaaccccga gtcgaggatc gtggtgccgg     1320

aaatcaagct gcacccctgg gtcacgaggc atggggcgga gccgttgccg tcggaggatg     1380

agaactgcac gctggtcgaa gtgactgaag aggaggtcga gaactcagtc aaacacattc     1440

ccagcttggc aaccgtgatc ctggtgaaga ccatgatacg taaacgctcc tttgggaacc     1500

cattcgaggg cagccggcgg gaggaacgct cactgtcagc gcctggaaac ttgctcacca     1560

aaaaaccaac cagggaatgt gagtccctgt ctgagctcaa ggggacaaaa aaaaaaaaag     1620

gacttgactc catgacgtcg accgtggccg ctggctggct ggacaggcgg gtgtgaggag     1680

ttgcagaccc aaacccacgt gcattttggg acaattgctt tttaaaacgt ttttatgcca     1740

aaaatccttc attgtgattt tcagaaccac gtcagatata ccaagtgact gtgtgtgggg     1800

tttgacaact gtggaaaggc gagcagaaaa ctccggcggt ctgaggccat ggaggtggtt     1860

gctgcatttg agagggagta gggggctaga tgtggctcct agtgcaaacc ggaaaccatg     1920

gcaccttcca gagccgtggt ctcaaggagt cagagcaggg ctggccctca gtagctgcag     1980

ggagctttga tgcaacttat ttgtaagaag gatttttaaa ttttttatgg gtagaattgt     2040

agtcaggaaa acagaaaggg cttgaaattt aataagtgct gctggaaggg gattttccaa     2100

gcctggaagg gtattcagca gctgtggtgg ggaaacattt ctcctgaaag actgaacgtg     2160

tttcttcatg acagctgctc aaagcaggtt tctgagatag ctgaccgagc tctggtaaat     2220

ctctttgtca aattacgaaa acttcagggt gaaatcctat gcttccatgt acattacatg     2280

gcttaagatt aaacaaaaac atttttcaag tctctaacta gagtgaactc tagagcacag     2340

tagttcagaa actatttaga gcttccagga tatatttcac agcttcaggc atgtgatcag     2400

ttagagccga tgaaacctat gcccgcctgt atatatatta gcagcttagc tagttcataa     2460

cctgtatatt ctaaagactg ctaaggtttt gttttcattt taaatcctag ctgattgttg     2520

tggtcaatga aatacccagt ttctggaggg ccaggtggga aatgctttca ctggaccaac     2580

acacaaatga tcatcctgag gatctgagct tccctagact ccacacaata accttggggc     2640

acccttttag agaagactgt tgaaacccac agcactcgtt ggggtatgag gaaaccaggg     2700

cttggcacag gaagttcccc tttgtagcta aaagtccaga aagaaagggt tcatcttttt     2760

gacttccaac tgatattggg aagtttggtt gaggttcaag tgtgactcct tccagagcca     2820

caggtagggg agtgtgaagt tgagggggag gaaagctgga aggactctgc cttgggagat     2880

tcccagctct gctttccagc gcttggtgga atctgggctg gggaaagacg gcaccgggaa     2940

actctgcttc cccattgttt ccatctgatc agctgtggtg tgaggacttc tcagacaaag     3000

gcaaggcctc gtgcccctgc ccagcccatt catggagccc tgggccttct tggcttccat     3060

agatcctaag ctcttgactg tagtttagcc agacttgttt tgctatctta taagcagttc     3120

agaattaggg aatgctggtt ttgaagagca aaggacaggt agtctagaga gggtcgtctg     3180

gcctgcttgc tgggtctttg taacccagca cttcctcttg ccctcctggc tttatgttta     3240

tggggagagg actcaatagc tccacccctt ctggcaccag atggggcttg gttagtttgc     3300

aataagcacc ttgcagaggt taaagccagc gggtccctag tcttaggccc agcctgcttg     3360

tgtgggctct ggcctggcct ggtggctggc ccagggggca gcagtgctta gagcttctgc     3420

agggcttctc ttgtttacac agctgcatca gacaatgcca tttctcccca ccacggaacc     3480

ttccatctaa gatttcttcc agggaatgcc agcaatcagg cagcacccag ctgtgggggc     3540

agtggggtgg gggagaccca cattgatgac tttttttttt tcttttaatg aagaaacacc     3600

aaagaaagct gtggaaagga cctgccccac atgaaaagga taagccaaga tggctgtaaa     3660

cacagagcat ttgagctgcc actcttggag cacattgatt tttcaaaagc cagctctgtc     3720

aggaaaggag gtgctgttat gagcagctct tccagtgggc aaagaggacg cccataattt     3780

cttccattgc tagctcatct gtgggaccaa tttggtgtaa gcaacctgtg gcctgcactt     3840

gtggcctcga aggaagcaca aaccctccat ccacttccca tttcctctgc ccttttccac     3900

ctcccccttc catcccacca gctgccagtg gctcccagaa agccttattg agccccttgt     3960

tgacacttgg ggctgcggag gcctctccct actggtctgg cctttcctga gaggcaggtc     4020

ttccgtcctc agagcctttc tggaacaagg agaatgcctg tgcaggtgga cacacaggcc     4080

tggcctgtcg ctctcacttg tcttccagcg gggagcttca cgttgccgag tggaagaacc     4140

atgacctcca cttgcttcca aggtgctagg gaagtttcag ggtacgctgg ttcccctctc     4200

cagctggagg ccgagtttct ggggactgca gatttttcta ctctgtgatc gattcaatgc     4260

ccgatgcttc tgtttcattc ccgacccttt ctactatgca ttttcctttt atcaggtgta     4320

taaagttaaa tactgtgtat ttatcactaa aaagtacatg aacttaagag acaactaagc     4380

ctttcgtgtt tttccacagg tgtttaagct tctctgtaca gttgaaataa acagacagca     4440

aaatggtgcc                                                            4450


<210> 2268
<211> 1165
<212> DNA
<213> Homo sapiens

<400> 2268
ccttggtgtg tgcataaggc cacatgacct caggtcagga ataaaagctt agggctgagc       60

agctcactct ttggttgaga atccagttgg ctcccctgga gtgaagttct acacagaccc      120

tggaggaacc accccatctg tttgttggag actgaaccgt tgcaaggaac agacgaagat      180

gcagtagcca gtgctgactt ctctagcatg ctctctgagg aggaaaagga agagttaaaa      240

gcagagttag ttcagctaga agacgaaatt acaacactac gacaagtttt gtcagcgaaa      300

gaaaggcatc tagttgagat aaaacaaaaa ctcggcatga acctgatgaa tgaattaaaa      360

cagaacttca gcaaaagctg gcatgacatg cagactacca ctgcctacaa gaaaacacat      420

gaaaccctga gtcacgcagg gcaaaaggca actgcagctt tcagcaacgt tggaacggcc      480

atcagcaaga agttcggaga catgagacga aagtaggcgg tacgaaccct aatggaggca      540

gttttgagga ggtcctcagc tccacggccc atgccagtgc ccagagcttg gcaggaggct      600

cccggcggac caaggaggag gagctgcagt gctaagtcca gccagcgtgc agctgcatcc      660

agaaaccggc cactacccag cccatctctg cctgtgctta tccagataag aagaccaaaa      720

tcccgctggg aaaaacccag gccttgacat tgttattcaa atggcccctc cagaaagttt      780

aatgatttcc atttgtattt gtgttgatga tggaccactt gaccatcaca tttcagtatt      840

catagatgac tgtcacattt taaaatgttc ccacttgagc aggtacacaa ctggtcataa      900

ttcctgtctg tgtaattcga tgtatatttt tccaaacatg tagctattgt ttgctttgat      960

ttttgcttgg cctcctttat gatgtgcatg tccttgaagg ctgaatgaac agtccctttc     1020

agttcagcag atcaacagga tggagctctt catgactgtc tccagcaata ggatgattta     1080

ctataaattt catccaacta cttgtgatct ctctcaccta catcaattat gtatgttaat     1140

ttcagcaatt aaaagaattg atttt                                           1165


<210> 2269
<211> 1149
<212> DNA
<213> Homo sapiens

<400> 2269
atggaagcag aacctaaagg tttgttggag actgaaccgt tgcaaggaac agacgaagat       60

gcagtagcca gtgctgactt ctctagcatg ctctctgagg aggaaaagga agagttaaaa      120

gcagagttag ttcagctaga agacgaaatt acaacactac gacaagtttt gtcagcgaaa      180

gaaaggcatc tagttgagat aaaacaaaaa ctcggcatga acctgatgaa tgaattaaaa      240

cagaacttca gcaaaagctg gcatgacatg cagactacca ctgcctacaa gaaaacacat      300

gaaaccctga gtcacgcagg gcaaaaggca actgcagctt tcagcaacgt tggaacggcc      360

atcagcaaga agttcggaga catgagttac tccattcgcc attccataag tatgcctgct      420

atgaggaatt ctcctacttt caaatcattt gaggagaggg ttgagacaac tgtcacaagc      480

ctcaagacga aagtaggcgg tacgaaccct aatggaggca gttttgagga ggtcctcagc      540

tccacggccc atgccagtgc ccagagcttg gcaggaggct cccggcggac caaggaggag      600

gagctgcagt gctaagtcca gccagcgtgc agctgcatcc agaaaccggc cactacccag      660

cccatctctg cctgtgctta tccagataag aagaccaaaa tcccgctggg aaaaacccag      720

gccttgacat tgttattcaa atggcccctc cagaaagttt aatgatttcc atttgtattt      780

gtgttgatga tggaccactt gaccatcaca tttcagtatt catagatgac tgtcacattt      840

taaaatgttc ccacttgagc aggtacacaa ctggtcataa ttcctgtctg tgtaattcga      900

tgtatatttt tccaaacatg tagctattgt ttgctttgat ttttgcttgg cctcctttat      960

gatgtgcatg tccttgaagg ctgaatgaac agtccctttc agttcagcag atcaacagga     1020

tggagctctt catgactgtc tccagcaata ggatgattta ctataaattt catccaacta     1080

cttgtgatct ctctcaccta catcaattat gtatgttaat ttcagcaatt aaaagaattg     1140

attttaatg                                                             1149


<210> 2270
<211> 773
<212> DNA
<213> Homo sapiens

<400> 2270
gtatttggta gctttaggct gcattaaacc actttgtgat cttttgactg ttatggactc       60

caaaatagtc caagtggctt taaatggact tgaaaatatt ttacgtcttg gagaacaaga      120

atctaagcag aatggaatag gcattaatcc atactgtgct ctcattgaag aagcatatgg      180

tctggataaa attgagtttt tgcaaagcca tgaaaatcag gaaatttacc agaaggcatt      240

tgatctgatt gaacattact ttggtgtaga agaagatgac cccagcattg tacctcaggt      300

ggatgaaaac caacaacagt ttatatttca gcagcaggaa gcaccaatgg atggatttca      360

actttaactt actggaggaa aaaaaattta tggctaaaaa gggtagcttc agaaatgaca      420

gactttttca ttgaatgatg aggacacagc agccatatta tgccaagagg aaaaatatca      480

tgatcatatt gaaagatcaa gcatgagctt ccatggtgaa gtcttctgta ccaatgcacc      540

agagaatgcc taccatccaa aaaagcagtc agctgatgga aaagaagatt attaaacctt      600

tgttctggga tttactgtta aaaaacaaac aaaaaacaac aaaaaagcgg tgacaggaaa      660

cagttaagga aatgatttaa ctgaagggaa gcaagatttt tttaaagcat tgttcttaat      720

ccccatgact gtccttcagt cacaattcca gaataaaaga atctactttg tgt             773


<210> 2271
<211> 2067
<212> DNA
<213> Homo sapiens

<400> 2271
cccctgaaag ctggcgaggc gcgcgcgctc ccgcggcacg ccgcgcctcc gccctccgcc       60

cgccaacccg ctggtccagt ccctcttcgc gcccgcttgg ctccgccccc ttcccaattc      120

gctcctcccc caacagactg gcggcgcgcg gaaaacgcgt cacgtgacga ctggccccgc      180

ctcttcctct cggtcccata ttgaactcga gttggaagag gcgagtccgg tctcaaaatg      240

gaggtaaaac cgccgcccgg tcgcccccag cccgactccg gccgtcgccg tcgccgccgg      300

ggggaggagg gccatgatcc aaaggaacca gagcagttga gaaaactgtt tattggtggt      360

ctgagctttg aaactacaga tgatagttta cgagaacatt ttgagaaatg gggcacactc      420

acagattgtg tggtaatgag agacccccaa acaaaacgtt ccaggggctt tggttttgtg      480

acttattctt gtgttgaaga ggtggatgca gcaatgtgtg ctcgaccaca caaggttgat      540

gggcgtgtag tggaaccaaa gagagctgtt tctagagagg attctgtaaa gcctggtgcc      600

catctaacag tgaagaaaat ttttgttggt ggtattaaag aagatacaga agaatataat      660

ttgagagact actttgaaaa gtatggcaag attgaaacca tagaagttat ggaagacagg      720

cagagtggaa aaaagagagg atttgctttt gtaacttttg atgatcatga tacagttgat      780

aaaattgttg ttcagaaata ccacactatt aatgggcata attgtgaagt gaaaaaggcc      840

ctttctaaac aagagatgca gtctgctgga tcacagagag gtcgtggagg tggatctggc      900

aattttatgg gtcgcggagg gaactttgga ggtggtggag gtaattttgg ccgtggtgga      960

aactttggtg gaagaggagg ctatggtggt ggaggtggtg gcagcagagg tagttatgga     1020

ggaggtgatg gtggatataa tggatttgga ggtgatggtg gcaactatgg cggtggtcct     1080

ggttatagta gtagaggggg ctatggtggt ggtggaccag gatatggaaa ccaaggtggt     1140

ggatatggtg gaggtggagg atatgatggt tacaatgaag gaggaaattt tggcggtggt     1200

aactatggtg gtggtgggaa ctataatgat tttggaaatt atagtggaca acagcaatca     1260

aattatggac ccatgaaagg gggcagtttt ggtggaagaa gctcgggcag tccctatggt     1320

ggtggttatg gatctggtgg tggaagtggt ggatatggta gcagaaggtt ctaaaaacag     1380

cagaaaaggg ctacagttct tagcaggaga gagagcgagg agttgtcagg aaagctgcag     1440

gttactttga gacagtcgtc ccaaatgcat tagaggaact gtaaaaatct gccacagaag     1500

gaacgatgat ccatagtcag aaaagttact gcagcttaaa caggaaaccc ttcttgttca     1560

ggactgtcat agccacagtt tgcaaaaagt gcagctattg attaatgcaa tgtagtgtca     1620

attagatgta cattcctgag gtcttttatc tgttgtagct ttgtcttttt ctttttcttt     1680

tcattacatc aggtatattg ccctgtaaat tgtggtagtg gtaccaggaa taaaaaatta     1740

aggaattttt aacttttcaa tatttgtgta gttcagtttt tctacatttt agtacagaaa     1800

ctttaacaaa atgcagtttc gaaggtgttt ccttgtgagt taacaagtaa agaagatcat     1860

tgttaattac tattttgtat gaattttgct aaagttaact gtaaagaaac acctgctgac     1920

ttgcagttta aggggaatct attctcccca tttccaaacc atgatatgaa tgggcgctga     1980

catgtggaga gaatagataa tttgtgtgtt tgcaatgtgt gttttagata aataggattg     2040

ggtatttaaa ttagcatttg tgaattt                                         2067


<210> 2272
<211> 3547
<212> DNA
<213> Homo sapiens

<400> 2272
ggaggtgagc aggaaggaga cggccgccca gcagcccgtg ggcaggcgcg gcggagcgag       60

cggggccggc ggcgggcgcc gagggacgcc gaggcctcgg gcgggggctg gcccggggtt      120

ccaggtctcc agtgggggct gcagactaag caaaatgagg cggttcctga ggccagggca      180

tgaccctgtg cgggagaggc tcaagcggga cctgttccag tttaacaaga cggtggagca      240

tggcttcccg caccagccca gcgccctcgg ctacagcccg tccctgcgca tcctggccat      300

cggcacccgt tctggagcca tcaagctcta cggagcccca ggcgtggagt tcatggggct      360

gcaccaggag aacaacgctg tgacgcagat ccacctcctg cccggccagt gccagctggt      420

caccctgctg gatgacaaca gcctgcacct ttggagcctg aaggtcaagg gcggggcatc      480

ggagctgcag gaggatgaga gcttcacact gcgtggaccc ccaggggctg cccccagtgc      540

cacacagatc accgtggtcc tgccacattc ctcctgcgag ctgctctacc tgggcaccga      600

gagtggcaac gtgtttgtgg tgcagctgcc agcttttcgt gcgctggagg accggaccat      660

cagctcggac gcggtgctgc agcggttgcc agaggaggcc cgccaccggc gtgtgttcga      720

gatggtggag gcactgcagg agcaccctcg agaccccaac cagatcctga tcggctacag      780

ccgaggcctc gttgtcatct gggacctaca gggcagccgc gtgctctacc acttcctcag      840

cagccagcaa ctggagaaca tctggtggca gcgggacggc cgcctgctcg tcagctgtca      900

ctctgacggc agctactgcc agtggcccgt gtccagcgaa gcccagcaac cagagcccct      960

ccgcagcctc gtgccttacg gtccctttcc ttgcaaagcg attaccagaa tcctctggct     1020

gaccactagg caggggttgc ccttcaccat cttccagggt ggcatgccac gggccagcta     1080

cggggaccgc cactgcatct cagtgatcca cgatggccag cagacggcct tcgacttcac     1140

ctcccgtgtc atcggcttca ctgtcctcac agaggcagac cctgcagcca cctttgacga     1200

cccctatgcc ctggtggtgc tggctgagga ggagctggtg gtgattgacc tgcagacagc     1260

aggctggcca ccggtccagc tgccctacct ggcttctctg cactgttccg ccatcacctg     1320

ctctcaccac gtctccaaca tcccgctgaa gctgtgggag cggatcattg ccgccggcag     1380

ccggcagaac gcacacttct ccaccatgga gtggccaatt gatggtggca ccagcctgac     1440

cccagcccca ccccagaggg acctgctgct cacagggcac gaggacggca cggtgcggtt     1500

ctgggatgcc tcgggtgtct gcctgcggct gctctacaaa ctcagcactg tgcgcgtgtt     1560

cctcaccgac acggacccca acgagaactt cagtgcccag ggcgaggacg agtggccccc     1620

actccgcaag gtgggctcct ttgaccccta cagtgatgac ccccggctgg gcatccagaa     1680

gatcttcctc tgcaagtaca gcggctacct ggctgtggca ggcacggcag ggcaggtgct     1740

ggtactggaa ctgaatgacg aggcagcgga gcaggctgtg gagcaggtgg aggccgacct     1800

gctgcaggac caagagggct accgctggaa ggggcacgag cgcctggcag cccgctcagg     1860

gcccgtgcgc tttgagcctg gctttcagcc cttcgtgttg gtgcagtgtc agcccccggc     1920

tgtggtcacc tccttggccc tgcactctga gtggcggctc gtggccttcg gcaccagcca     1980

tggctttggc ctctttgacc accagcagcg gcggcaggtc tttgttaagt gcacactgca     2040

ccccagtgac cagctggcct tggagggccc actctcccgc gtcaagtccc tcaagaagtc     2100

cttgcgtcag tcattccgcc ggatgcgtcg gagccgggtg tccagccgga agcggcaccc     2160

ggctggcccc ccaggagagg cacaggaggg gagtgccaag gctgagcggc caggcctcca     2220

gaacatggag ctggcgcctg tgcagcgcaa gatcgaggct cgctcggcag aggactcctt     2280

cacaggcttc gtccggaccc tgtactttgc tgacacctac ctgaaggaca gctcccggca     2340

ctgcccctcg ctgtgggctg gcaccaatgg gggcaccatc tatgccttct ccctgcgtgt     2400

gcctcccgcc gagcggagaa tggatgagcc tgtgcgggca gagcaggcca aggagatcca     2460

gctgatgcac cgggcgccgg tggtgggcat cctggtgctc gacggacaca gcgtacccct     2520

tcccgagccc ctcgaagtgg cccatgatct gtcgaagagc cctgacatgc agggaagcca     2580

ccagctgctc gtcgtatcag aggagcagtt caaggtgttc acgctgccca aggtgagtgc     2640

caagctgaag ttgaagctga cggccctgga gggctcaaga gtgcggcggg tcagcgtggc     2700

ccacttcggc agtcgtcgag ccgaggacta cggggagcac cacctggcag tccttaccaa     2760

cctgggcgac atccaggtgg tctcgctgcc cctgctcaag ccccaggtgc gctacagctg     2820

catccgccgg gaggacgtca gtggcatcgc ctcctgcgtc ttcaccaaat atggccaagg     2880

cttctacctg atctcaccct cggagtttga gcgcttctct ctctccacca agtggctggt     2940

ggagccccgg tgtctggtgg attcagcaga aaccaagaac caccgccctg gtaacggtgc     3000

gggccccaag aaggccccga gccgagccag gaactcaggg actcagagtg atggcgagga     3060

gaagcagccc ggcctggtga tggagcgcgc tctgctcagt gatgagagag tcctgaagga     3120

aatccagagc acactggagg gagaccgcgg gagcggcaac tggcgttcac atcgagccgc     3180

cgtggggtgc agcctcagca atggcggagc agagtgagtg gctgagcgtc caggctgcgc     3240

gatgagcaca cactactact gatggccttt cgggggtccc tgccccaacc ggagaggccg     3300

gtgcacaggg ccccgccagg ggctgggggc atcccggctt ccacaatgca gctgctctgg     3360

gcctcgggag aggagagacc ccagtcccct gggctgccct tcccgggcct cgtctgtctg     3420

ggtcctttgg tcaatgttgc acagttttta ttgctcccat ccctttttgt agtgggctgg     3480

gttttaagtt ataaatgtta actgcctctg ggtgaaaaag tttttaataa acacctatta     3540

cctcttg                                                               3547


<210> 2273
<211> 2176
<212> DNA
<213> Homo sapiens

<400> 2273
cgggcgggcg ggcgggacgg cgccccccgc ggccgggcct ggccgggctg cgctaggctg       60

ggctcgggca gggtcgcagg ggcgggggtg gcaggggagc gggtggcagc cccgcgggtc      120

acagcgccgc cgccgcccat gctgctgccc ctagcctgcc tgcacggccg cgtcgctcag      180

tgcctgacct ccttgctttt gcttgcagag ccgctcccga ggccccggcg cggcgcgagg      240

gcgcggggcg cggcgtccac aggcgccgag gctgcccccg ccgccccgcc cgcgaagatg      300

gcggcggaac tctacgctcc cgccagcgcc gcggccgcgg acctagccaa cagcaacgcc      360

ggcgccgccg tgggcaggaa ggccgggccg cgcagcccgc ccagcgcccc cgcgccagcg      420

ccgccgccgc ccgcgcccgc gccgcccaca ctcggcaaca accaccagga gagccccggc      480

tggcggtgct gccgccccac gctgcgcgag aggaacgcgc tcatgttcaa caacgagctc      540

atggccgacg tgcacttcgt cgtggggccc ccgggggcga ccaggacggt gcccgcccac      600

aagtacgtct tggctgtcgg cagctccgtc ttctatgcca tgttctacgg agacctggcg      660

gaagtcaaat ctgaaattca cattccagac gtggagcccg cagcctttct gatcctctta      720

aagtacatgt acagtgatga gatcgatctg gaagccgaca cggtgctggc cactctgtac      780

gctgctaaga agtacatcgt cccagcattg gcaaaagcct gtgtcaactt tctggagaca      840

agtttggaag ccaagaacgc ctgcgtcctg ctgtcccaga gccggctgtt tgaggagccc      900

gagctgacgc agcgctgctg ggaggtcatt gacgcacagg ccgagatggc cctacggtcc      960

gaaggcttct gtgagataga ccggcagacg ctggagatca ttgtcactcg ggaggccctc     1020

aacaccaaag aggcggtggt cttcgaggcc gtcctgaact gggccgaggc ggagtgcaag     1080

aggcaggggc tgccaatcac cccacgaaac aagaggcatg ttctggggcg agccctctat     1140

ctggtccgaa ttccaaccat gaccctagag gagtttgcca acggcgctgc ccagtcagac     1200

atcctgactc tggaggagac ccacagcatc ttcctgtggt acacggccac caacaagccc     1260

cgcctggact ttcccctgac caagaggaag ggcctcgccc cgcagaggtg ccaccgattc     1320

cagtcttctg cctaccgcag caaccagtgg cggtaccgcg ggcgctgcga cagcatccag     1380

tttgcagtgg acagaagggt atttattgca gggctgggcc tgtatggctc cagctctggg     1440

aaggctgagt acagcgtgaa gattgagctc aagcggctcg gggtggttct ggctcagaac     1500

ttgaccaagt tcatgtcaga cggatccagt aacaccttcc cggtctggtt tgaacacccg     1560

gtccaggttg aacaagacac cttctacacg gccagtgccg tcctggacgg cagcgaactc     1620

agctactttg ggcaggaggg gatgacggaa gtgcagtgtg gaaaggtggc cttccagttc     1680

cagtgctcct cggacagcac caacgggact ggggtccagg gtgggcagat ccctgagctc     1740

attttctatg cctgaggtgc ccggggaggc tgcagcaggt cagcgagtga gtggagggga     1800

agtcaagatg ctaactgctt cttgacacca tgaaaggctg ctcttaactt tgtctctctt     1860

tgacatgtag tcagctgaag cttgactgtg tagagacatt ttccacacag ccagaaccca     1920

gggattggag tcttaggcat ctctggtaca gtggggtgca cgtctcaggt ggaggaagat     1980

ttacggctca agacaggccc cagatcccct cccagtggca cccatgccac ctgctttgag     2040

gggttggatc ttcctgctac cctcttggat tctaagtggt tccaagctta acttgagacc     2100

ttcccttcaa atctaaaatt ggcaaaaagt cacttaaaat agtggacttc tgtaataaag     2160

gttgcctaaa ataaca                                                     2176


<210> 2274
<211> 3571
<212> DNA
<213> Homo sapiens

<400> 2274
gcggcgccca gggcggtagc gtgaaacttg gtggaagacg ctgaccagtc gtgttggaat       60

caaaacagcg gggaccctgc gccatgtcgc gactgatcgt gaagaatctc ccgaatggga      120

tgaaggagga gcgtttcagg cagctgtttg ccgccttcgg cacgctgaca gactgcagcc      180

tgaagttcac caaagatggc aagttccgca agtttggttt tattggcttc aagtccgagg      240

aagaggccca gaaggcacag aagcatttca acaagagctt catcgacaca tcccggatca      300

cagtggagtt ctgcaagtca ttcggggacc cggccaaacc cagagcctgg agcaaacatg      360

cccagaaacc aagccagccc aagcagcctc caaaagactc tactactcca gaaattaaga      420

aagatgagaa gaagaaaaag gtggcaggtc aactggagaa gctgaaggag gatacagagt      480

tccaggagtt tctgtcagtt catcagaggc gggcgcaggc agccacttgg gcgaatgatg      540

gcctggatgc tgagccctcg aaagggaaga gcaagccggc cagtgactac ctgaacttcg      600

actccgattc tgggcaggag agtgaggagg agggagccgg ggaggacctg gaagaagagg      660

caagcctcga accaaaggca gctgtgcaga aggagctgtc ggacatggat tacctgaaat      720

ccaagatggt gaaggctggg tcgtcctctt cctcggagga agaggaaagt gaagatgaag      780

ccgtgcactg tgatgaaggg agtgaggccg aggaagagga ttcctccgcc accccagtcc      840

tgcaggaaag agacagcaag ggtgcaggcc aagagcaagg gatgccagct gggaaaaaga      900

gaccaccgga ggccagagcc gagacagaga aaccagcaaa ccagaaggaa cccaccacct      960

gccacaccgt gaagctgcgg ggagccccgt tcaatgtcac agagaaaaat gttatggaat     1020

tcctggcacc cctgaaacca gtggccattc gaattgtgag aaacgctcat gggaataaaa     1080

caggatacat ctttgtggat ttcagcaatg aagaggaagt gaagcaagct ctgaaatgca     1140

accgggagta catgggtggg cgctacatcg aggtgttcag ggaaaagaac gtccccacca     1200

ccaagggtgc accaaagaat accaccaaat cctggcaagg ccggatactc ggggagaacg     1260

aagaggagga ggacctggcc gaatccggaa ggctctttgt acggaacctg ccctacacca     1320

gcaccgagga ggatctggag aagctcttct ccaaatatgg tcccctgtct gagctccact     1380

accccatcga cagcctgacc aagaaaccca agggttttgc attcatcacc ttcatgttcc     1440

ctgagcacgc tgtgaaggcc tactcggagg tggacgggca ggtattccag ggcaggatgc     1500

tccacgtgtt accatctacc atcaagaagg aagccagcga ggatgccagt gccctgggat     1560

cgtcgtccta caagaagaag aaggaggccc aggacaaagc caacagtgcc agctctcaca     1620

actggaacac actattcatg gggccgaatg ccgtggccga tgccatcgca cagaagtaca     1680

acgccaccaa gagtcaagtg tttgaccacg agaccaaggg cagcgtggcc gtgcgcgtgg     1740

ctctggggga aacccagctc gtccaggaag tgcggcgttt tctcatagac aacggggtca     1800

gcctggattc cttcagccag gctgcagcag agcgaagcaa gactgtgatt ctggtcaaga     1860

acctcccggc aggcaccctg gcggcccagc tgcaggagac cttcggccat tttggcagcc     1920

tgggccgcgt gctgctgcca gagggcggaa tcactgccat cgtggagttc ctggagcccc     1980

tggaggcccg caaggccttc aggcatctgg cctattccaa gttccatcat gtccccctct     2040

atctggagtg ggctccagtt ggcgtcttct ccagcacagc cccacagaag aaaaagctcc     2100

aagacacacc ttcagaaccc atggaaaagg acccagcaga gccagaaaca gtgcctgatg     2160

gcgaaacccc agaagatgaa aatccaacag aggaaggagc agacaactct tcagcaaaga     2220

tggaagagga ggaggaggaa gaggaagaag aagaagagag cctcccagga tgtactctgt     2280

ttattaagaa tctcaatttt gacacaacag aagagaagct gaaggaagtg ttttcaaaag     2340

tggggacagt gaagagctgc tccatctcca agaagaagaa caaagcagga gtgctccttt     2400

ccatggggtt tggatttgtg gaatacagga agccggagca agcccagaaa gctctcaagc     2460

agctccaggg tcacgtcgtg gacggccaca agctggaagt gaggatctcg gaacgagcca     2520

ctaagccagc cgtgacattg gctcggaaga aacaagttcc cagaaagcag accacctcca     2580

agatcctggt gcggaacatc cccttccagg cccacagccg ggagatccga gagctcttca     2640

gcacctttgg ggagttgaag acggtccgcc tgccaaagaa gatgactggg acaggcacac     2700

acagaggctt cggctttgtg gacttcctca ccaagcagga tgcgaagaga gccttcaacg     2760

ccctgtgtca cagcacccac ttgtacgggc ggaggctggt gctggagtgg gccgactccg     2820

aggtgaccct gcaggccctg cggcggaaga cggccgctca ctttcacgag cccccgaaga     2880

aaaagcggtc tgtggtgttg gacgagatcc tggagcagct ggaaggcagt gacagcgaca     2940

gcgaggagca gacccttcag ctgtgagctg gcaccgagag gggctgctga gctagaattc     3000

ccacctatgt ctttccaagg gactgttcac ggcttgggac ttggtctctg tcctgcccca     3060

tcctcgtcac ttgggaccac gagccctggt tcagtcaccc agggaagcct cccagcggct     3120

catgaagcat cgagctccaa gcccagatgc caagctccct ggctgagctg aatgatgtca     3180

ctcatggtgg acgcgttctg ctcacgggcc cagagccctg tgaaatgcat caaggtcctc     3240

tccgctggcc agcagcatcc ccaggcttct ctcaggcgcc cgtgttcaca ttttctccag     3300

cctgagacgc agcctcccgc ctggaagggc ctgtgccagc accaggcaga gggcaagacg     3360

gagagggcag agcaagaact gcactgcatc tcactgcagt ctgaatctag acatcgccat     3420

tccccgaggt gcgacctcag actaatgaca tcctggctga gcctctgttt ttctctctag     3480

gaaatggggg tgataattgt gcctacctca gatagacagt gccagaatta agtgagtcaa     3540

gccaagtaaa gcccagagaa gattctcatc a                                    3571


<210> 2275
<211> 845
<212> DNA
<213> Homo sapiens

<400> 2275
gtcacgcgcc cgcccgaagg ctcctgtcgg gacagggcgc cgccccgtgt cggcccccgc       60

agagctcgcg gcccccgcct gtccgggcgc cgccatggag cgcatcgagg gggcgtccgt      120

gggccgctgc gccgcctcac cctacctgcg gccgctcacg ctgcattacc gccagaatgg      180

tgcccagaag tcctgggact tcatgaagac gcatgacagc gtgaccgttc tcttattcaa      240

ctcttctcgg aggagcctgg tgttggtgaa gcagttccgg ccagctgtgt atgcgggtga      300

ggtggagcgc cgcttcccag ggtccctagc agctgtagac caggacgggc ctcgggagct      360

acagccagcc ctgcccggct cagcgggggt gacagttgag ctgtgtgccg gcctcgtgga      420

ccagcctggg ctctcgctgg aggaagtggc ttgcaaggag gcttgggagg agtgtggcta      480

ccacttggcc ccctctgatc tgcgccgggt cgccacatac tggtctggag tgggactgac      540

tggctccaga cagaccatgt tctacacaga ggtgacagat gcccagcgta gcggtccagg      600

tgggggcctg gtggaggagg gtgagctcat tgaggtggtg cacctgcccc tggaaggcgc      660

ccaggccttt gcagacgacc cggacatccc caagaccctc ggcgtcatct ttggtgtctc      720

atggttcctc agccaggtgg cccccaacct ggatctccag tgagactcca gggttctaga      780

cagaggccag tcttggccac tcaccccaca ccccgcggac cccaataaag gcttgcatag      840

ctcca                                                                  845


<210> 2276
<211> 1697
<212> DNA
<213> Homo sapiens

<400> 2276
agctgggcag agccctgggg gcgcggtgct gccgcctcca ggtctccgcc ccgtgtgtgc       60

gccctgcact tagggatccc tccctcactg ccccggtact cacaagcttc tcggccccga      120

ccttcgccct gggaggttct ggccaggtgc cgggaggggc gctgtgtcga gggcgatccc      180

cccaaagcag cgtcccgtgc taaagaaaca gagcctcact ctgtcaccta ggctggagtg      240

cagtggtgca attatggctc actgcagttt caacctccca gattccagtc atcctcctgc      300

ctcagccacc caagaagctg ggaccacagg tactgcttag gatgaatatg atttggagaa      360

attccatttc ttgtctaagg ctaggaaagg tgccacacag ataccaaagt ggttaccacc      420

cagtggcccc tctgggatca aggattttaa ctgacccagc caaagttttt gaacacaaca      480

tgtgggatca catgcagtgg tctaaggaag aagaagcagc agccagaaaa aaagtaaaag      540

aaaactcagc tgtgcgagtc cttctggaag agcaagttaa gtatgagaga gaagctagta      600

aatactggga cacattttac aagattcata agaataagtt tttcaaggat cgtaattggc      660

tgttgaggga atttcctgaa attcttccag ttgatcaaaa acctgaagag aaggcgagag      720

aatcatcatg ggatcatgta aaaactagtg ctacaaatcg tttctcaaga atgcactgtc      780

ctactgtgcc tgatgaaaaa aatcattatg agaaaagttc tggttcttca gaaggtcaaa      840

gcaaaacaga atctgatttt tccaacctag actctgaaaa acacaaaaaa ggacctatgg      900

agactggatt gtttcctggt agcaatgcca ctttcaggat actagaggtt ggttgtggag      960

ctggaaatag tgtgtttcca attttgaaca ctttggagaa ctctccggag tcctttctgt     1020

attgttgtga ttttgcttct ggagctgtgg agctcgtaaa gtcacactcg tcctacagag     1080

caacccagtg ttttgccttt gttcatgatg tatgtgatga tggcttacct tacccttttc     1140

cagatgggat cctggatgtc attctccttg tctttgtgct ctcttctatt catcctgaca     1200

ggacattgtt tatctgaaaa tttttatgtt cgaggagatg gtaccagagc atatttcttt     1260

acaaaagggg aagtccacag tatgttctgc aaagccagtt tagatgaaaa gcaaaatctg     1320

gttgatcgcc gcttacaagt taataggaaa aaacaagtga aaatgcactg agtgtggatt     1380

caaggcaaat tccagaaacc attgcaccag actcagaata gctccaatat ggtatctaca     1440

ctcctttcac aagactgaac tttgtaacat gttaaggtac aaagccagag gactgtgcta     1500

ttcaaggact actgtaagtc tattgtttct caaaagacaa tgagaaaaaa agaagagaat     1560

ttgtatttcc tgccgttttg tcataggtga gctcctttgt gcattttaag cacatgtaag     1620

tggttcagca cagtatgcct ttttctgtgc tttgaaaact tgatatgctc aagcttgttt     1680

gaatttatta catctaa                                                    1697


<210> 2277
<211> 800
<212> DNA
<213> Homo sapiens

<400> 2277
gaacgcgtgc gcgcgtgcgg cctggcgctt ccggcaccgg ccgaggtgcg ggtcgcctcc       60

agagatcctg tgccttcaaa ccctacgagt ccatacttta aaacaaaatg aagaaagtaa      120

ggcttaagga actagagagt cgcctgcaac aagtggatgg atttgaaaag cccaagctac      180

ttctggaaca gtatcctacc aggccgcaca ttgcagcatg tatgctctat acaatccata      240

acacttatga tgacattgaa aataaagtcg ttgcagatct aggatgtggt tgtggagtac      300

ttagcatcgg aactgcaatg ttaggagcag ggttgtgtgt tggatttgac atagatgaag      360

acgcattgga aatatttaat aggaatgcag aagagtttga gttaacaaat attgacatgg      420

ttcaatgtga tgtgtgctta ttatctaaca gaatgtccaa gtcattcgat acagtaatta      480

tgaatcctcc ctttgggacc aaaaataata aagggacaga tatggctttt ctaaagactg      540

ctttggaaat ggcaagaaca gcagtatatt ccttacacaa atcctcaact agagaacatg      600

ttcaaaagaa agctgcagaa tggaaaatca agatagatat tatagcagaa cttcgatatg      660

acctgccagc atcatacaag tttcacaaaa agaaatcagt ggacattgaa gtggacctaa      720

ttcggttttc cttttaaaag ccccgcaaac aaaagtcgtt taaaacctat ttaaaatgaa      780

taaaaaattg gtttactaaa                                                  800


<210> 2278
<211> 615
<212> DNA
<213> Homo sapiens

<400> 2278
acctcgccca ggctgccaga ccggaagcgc tccgctgtac ctggatcctg ctcctctggg       60

ttgaaacccg ggcgccgcca agatgccggc ttaccactct tctctcatgg atcctgatac      120

caaactcatc ggaaacatgg cactgttgcc tatcagaagt caattcaaag gacctgcccc      180

cagagagaca aaagatacag atattgtgga tgaagccatc tattacttca aggccaatgt      240

cttcttcaaa aactatgaaa ttaagaatga agctgatagg accttgatat atataactct      300

ctacatttct gaatgtctga agaaactgca aaagtgcaat tccaaaagcc aaggtgagaa      360

agaaatgtat acgctgggaa tcactaattt tcccattcct ggagagcctg gttttccact      420

taacgcaatt tatgccaaac ctgcaaacaa acaggaagat gaagtgatga gagcctattt      480

acaacagcta aggcaagaga ctggactgag actttgtgag aaagttatca agggtgattt      540

gaaattttct gcagcattaa agctggcgct taataagaat aagtaataat aaagaaattt      600

ctaacattcc atgtc                                                       615


<210> 2279
<211> 6152
<212> DNA
<213> Homo sapiens

<400> 2279
atggcggaca ccgacctgtt catggaatgt gaggaggagg agttggagcc atggcagaaa       60

atcagtgatg tcattgagga ctctgtagtt gaagattata attcagtgga taaaactacc      120

acagctggca atcctttggt ccagcaaggt ggacagccac tcatcctgac ccagaatcca      180

gccccaggtc tgggcacaat ggttactcaa ccagtattga ggcctgttca ggtcatgcag      240

aatgccaatc atgtgactag ttcccctgtg gcctcacaac caatatttat cactacgcag      300

ggatttcctg taaggaatgt ccggcctgta caaaatgcaa tgaatcaggt tgggattgtg      360

ctgaacgtac agcaaggcca aacggttaga ccaattacac tagttccagc cccaggtacc      420

cagtttgtta agccgacagt tggagttcca caagtgttct cccagatgac ccctgtgagg      480

ccaggctcca caatgcctgt gaggcccacc accaacacct tcaccaccgt catcccggcc      540

actcttacca ttcgaagcac cgtcccacag tcccagtccc agcagaccaa gtccactccc      600

agcacttcta ccactcccac tgccacacag ccaacctcac tggggcaact agctgttcag      660

tctccaggcc agtcaaacca gaccacgaat cccaagctag ctccctcctt cccctctcca      720

cctgcagtga gcattgccag ctttgtcact gtgaagcgac ctggtgttac aggcgaaaat      780

agcaatgaag tggccaaatt ggtgaatacc cttaacacca tcccttccct gggccagagt      840

cctgggccag tggtggtgtc caacaacagc tctgctcatg gctctcaaag aaccagcgga      900

cctgagtctt caatgaaagt gacctcttcc atcccagtat ttgacctcca ggatggtgga      960

cggaaaatat gtccacgatg taatgctcaa tttcgtgtta ctgaagcttt gagaggtcac     1020

atgtgttact gttgcccaga aatggttgaa taccagaaga aaggaaagtc cctggattca     1080

gaacccagtg tcccatcagc agcaaagccc ccatcccctg agaaaacagc tcctgttgct     1140

tccacaccct cttctacacc tattcctgct ctgtcaccgc ctaccaaagt accagaacca     1200

aatgagaacg tgggcgatgc cgtccagacc aaactcatta tgcttgtaga tgacttctac     1260

tatggacggg atggtggcaa agtagcccag ctcacaaatt tccctaaggt cgccacatct     1320

ttccgatgcc cacattgtac caaaaggcta aaaaacaata ttcgattcat gaaccatatg     1380

aaacaccacg tagaactcga tcagcagaac ggtgaggtag atggtcacac tatctgccag     1440

cactgttacc gccagttttc cactcccttc cagcttcagt gccacttgga aaatgttcat     1500

agtccctatg aatctactac caagtgcaag atctgtgaat gggcgtttga aagtgagcca     1560

ctatttctcc agcatatgaa ggatactcat aagcctggag agatgcctta tgtttgccag     1620

gtgtgtcaat atcgctcctc actctactct gaggtagatg tccattttcg gatgatccat     1680

gaggataccc ggcatctgct ctgcccttat tgcctgaagg tcttcaaaaa tggcaatgca     1740

ttccaacagc attacatgag gcaccagaag agaaatgttt atcactgcaa caaatgccgg     1800

ctgcagtttc tctttgccaa ggacaaaatt gaacacaagc ttcaacacca taaaaccttc     1860

cgtaaaccca agcagctgga gggcttgaaa ccaggcacca aggtgacaat ccgggcttcc     1920

cgagggcagc cacgaactgt tcctgtatcc tctaatgata cacctcccag cgccttgcag     1980

gaggcagcac cgctgacctc ctcaatggac cctctgcctg tcttccttta tccccctgtc     2040

cagcgcagca tccagaagag agctgttagg aaaatgagtg tcatgggccg gcagacatgc     2100

ctggagtgca gcttcgagat cccagacttc cctaatcatt tccctactta cgtacactgc     2160

tctctgtgtc gctatagcac ctgctgttct cgagcttatg ccaaccacat gatcaacaat     2220

catgttccac ggaagagccc caagtatttg gctttgttta aaaattctgt gagtggaatc     2280

aagctggcct gcacttcatg tacctttgtt acctctgtgg gcgatgctat ggccaagcat     2340

ttggtattca acccctctca cagatccagc agcatcctgc cacggggact cacttggata     2400

gctcactcaa ggcatggcca gactcgtgac cgagtgcatg accggaacgt gaagaatatg     2460

taccctcctc cttccttccc cactaacaaa gctgccactg tgaaatctgc gggggccacc     2520

ccagctgagc ctgaagagct actaactccc ttagccccag cactcccatc accagcctca     2580

actgcaaccc caccaccaac ccccactcac ccgcaggctt tagcccttcc accgctggct     2640

acagagggag ccgaatgtct gaatgttgat gatcaggatg aagggagccc agtcacccaa     2700

gaacctgagc tagcatcagg tggtggtggt agtggtggag ttggcaaaaa ggagcagctg     2760

tctgtgaaga agcttcgagt agtactgttt gctctatgct gcaatacaga acaggcagct     2820

gaacacttcc gaaatcccca gcgacgtatt cgccgttggc ttcgacgttt ccaggcctcc     2880

cagggggaga atctagaggg caaatatctg agctttgagg cagaagagaa actggctgag     2940

tgggtgctaa cccagcgcga acaacagcta cctgtaaatg aggagacctt gttccagaag     3000

gccaccaaaa taggacgttc tttggaaggg gggtttaaga tctcctatga gtgggctgtg     3060

cgtttcatgc tgcggcacca cctgactccc catgcccggc gagctgtggc ccacacccta     3120

cctaaggatg tagcagagaa tgcaggactc ttcattgatt ttgtacaacg gcagattcac     3180

aaccaggact tacccttgtc tatgattgtg gctattgatg agatctcttt gttcctggat     3240

acagaggtgc tgagcagtga tgatcgaaag gagaatgccc tgcagacagt gggcacaggg     3300

gaaccttggt gtgatgtagt cctagccatt ctggcagatg gcactgtcct tcccaccctg     3360

gttttctaca gagggcagat ggatcagcct gctaacatgc cagactccat attgctagag     3420

gcaaaggaga gtggctacag tgatgacgag atcatggagc tgtggtcaac tcgagtgtgg     3480

cagaagcaca cagcttgcca gcgcagcaaa ggcatgcttg tgatggactg tcatcgcact     3540

cacttgtcag aagaggtact ggctatgctt agtgcctcta gcactttgcc tgcagtggtc     3600

ccagcaggct gtagctccaa aattcagcca ttagatgtat gcatcaaaag aactgtcaag     3660

aacttcctgc ataaaaaatg gaaggaacag gctcgggaaa tggcagatac tgcatgtgat     3720

tctgatgtcc tgcttcagct ggtgcttgtc tggctgggtg aagtgctagg tgtcattggg     3780

gactgtccag agctagttca gcgctccttc ctggtggcta gtgttctgcc tggccccgat     3840

ggcaacatta actcacctac aagaaatgct gacatgcagg aggagctaat tgcctcccta     3900

gaggagcaac tgaagctgag tggggaacat tctgagtctt ccactccacg acccagatca     3960

tctcctgaag agacaattga gcctgaaagt cttcaccagc tctttgaggg tgaaagtgag     4020

accgagtctt tctatggctt tgaagaagct gacctagatc tgatggagat ttgagtgttg     4080

gggtcatgag ggggtgtgga gtgagggtgg gaacatgtga gggagggtaa aggggcttag     4140

ggaaaagggg gcataccagg tggggtattt ggtttctatt ttttaatttt ataccaccac     4200

tcccccctga agttgactta cacttccctg tggatttgtg gattaattag gaaaaccaat     4260

agtaatcacg tctgagccaa ggagctggcc cattggtcat tcacttctgc taaaaacagg     4320

tttttgtgac tttttttttt tttaaattta aatcactgtg tttggtattt ttctgacaaa     4380

attaagaaaa agaaaaaaaa ttatttgtgg gcaaatgtta aatttttttg tttccccttt     4440

tacctcaatt gtatcatagt actgggtttt tttgtttgtt ttattgtgtg gccaatgtct     4500

ttgggcatga tgctatctaa tcattgttaa tgtgagaaca tttctgaaga tgggaaagac     4560

aaattatgta gctcacaaac tggtttatta tatatatgga taaaaaactt ttttcattgt     4620

ggtcttaaca cttttatata aaaatgaaaa tggaaaaaaa gtcccactga actctctctt     4680

ccttctcctt ttctttcctt ccctctccag agatgttggt ttctacagca accctagata     4740

taaaattgtg gctttaaaaa tgcatgaaac cacctttaat tatccagaat gaatagattt     4800

gtcttttcct caccaccttc cctccaaaac atgacataaa caatattttt tgcacttgtg     4860

atccttggcc cctttcccca ttctcaacac catccatccc tctggacaaa ggatcataca     4920

ggtgttatta gcaagcaaga gatactgaag cgatcaaaca gttttagggt ggaagccatt     4980

cccagtttga gtcttcatcc tgtaagcccc caggggcagt ccctgcttta ctgaacttca     5040

tcctgttaga tggagagcat gcctgtttaa gggattactg gtcctacagc caggagctaa     5100

ttgttcaaga agtgttgaac tttaaaaaga caagaccact tgttgaaatc cagcgtgctc     5160

tgtggctttc ccctatttct cttaatactt agggaagaat ctgacaggaa gaagcgcaca     5220

ggggtgtgca caaagaaaat gacatgaatc tttatttttc actgccagct tcaaggaaag     5280

aaaatttttt ctacaatttg catgagggat ttttttaatt gtatgtactc atggttgtaa     5340

accaaaacgt actgtaccgt acagagaaaa ggagcaaaaa accaagtctt ctgtttatcc     5400

tgaggctttc cacaatgttc ccctcctgtg agccaaggag gcaaactgca caagcttgta     5460

aatggttcgt ctttaaaatg tacataagtg gaacatttaa taaaatgagg ggaaatggat     5520

ttataaactt gttttttttc taggtgaccc tgtttaatag gctttcacag actggggaat     5580

gctcaagatg tgatgggcct ggtggtacag gtgtgacatt tgttaccacc catttctccc     5640

accccaccct gcttttttgt ttgtttgttt tttcatcccc cagcacacta taatatagtg     5700

aactggaaaa gtcccttcca gaaacagctt ggccagcttt gtgaaccttt gacatctgaa     5760

aacaaccaag gatccatctg ggcttctctt ccccagcttt ttgcctgatg ccattttatt     5820

gacagacaat ggactttgaa gtcagccttt gcctttgaga aagttcaaga actatggttg     5880

gtcacgtcta tctacaacct aatcctactc tttggtagtc tctgcagcag ccacagcctt     5940

agcagagctg gggttcctgt cttctgcaca cgattgactt tcttgatggg taattttttt     6000

taagattata ccaacagtgg atcagctggg ttttggccag gaagttgtct ttgtggactc     6060

tgcctgcatg gcttagtagt agaaggaaat ttttttttgg ttttgttttt tataattcag     6120

tttaatcaat aaacatgtat ttattgactg tt                                   6152


<210> 2280
<211> 365
<212> DNA
<213> Homo sapiens

<400> 2280
cagaagaata gaaggaaggt gataggatgt gatgatagaa tttgtgatag ccaagcaaca       60

acttttccta attcggcatg ttaaaaaata agggtcactc atctaagaaa gataacttgg      120

cagtcaatgc agttgcttta caagatcaca ttttacatga tcttcaactt cgaaatcttt      180

cagttgcaga tcattctaag acacaagtac aaaagaaaga gaacaaatct ctaaaaagag      240

atacaaaggc aataatagat actggactta aaaaaactac acagtgcccc aaactagaag      300

actcagaaaa agaatatgtt cttgatccca aaccgccgcc gttgactttg ggataccatt      360

catag                                                                  365


<210> 2281
<211> 2260
<212> DNA
<213> Homo sapiens

<400> 2281
cgtctttgca gcagaagaat agaaggaagg tgataggatg tgatgataga atttgtgata       60

gccaagcaac aacttttcct aattcggcat gttaaaaaat aagggtcact catctaagaa      120

agataacttg gcagtcaatg cagttgcttt acaagatcac attttacatg atcttcaact      180

tcgaaatctt tcagttgcag atcattctaa gacacaagta caaaagaaag agaacaaatc      240

tctaaaaaga gatacaaagg caataataga tactggactt aaaaaaacta cacagtgccc      300

caaactagaa gactcagaaa aagaatatgt tcttgatccc aaaccgccgc cgttgacttt      360

ggcacagaag ttgggcctca ttgggcctcc accacctcca ctgtcatcag atgaatggga      420

gaaggtgaaa cagcgctctc tcctgcaagg ggactccgtg caaccatgcc ccatctgtaa      480

agaagaattc gagcttcgtc ctcaggtgct gctttcatgc tcccatgtgt tccacaaagc      540

atgtcttcag gcttttgaaa agttcacaaa taagaaaacc tgtcctctct gtagaaagaa      600

ccagtatcaa acccgagtga tacacgatgg ggcccgcctg ttcagaatca agtgtgtgac      660

cagaatccaa gcctactgga gaggatgtgt tgttagaaag tggtacagaa acctgaggaa      720

aacagtacct cccacagatg ccaagttaag aaaaaaattc tttgaaaaaa agacacaaga      780

ctggaaacca gcttaatttt tcccatctcc tgggctatat gtaaatgaag acatctgctg      840

cacatctcat agtaatgaaa atagaagctg cctataaaaa taaagccccc acatgctacc      900

attgtattga gtacctcgtg gggtcatcac aatgagcttt agagctaact tccatgtcta      960

cccttcctct taaccactat ttatgcttta gttttacttt tgggggactt atttaacaat     1020

ttcccattcc ttgtccccat atgaaaagga cagtcctacc ccatcagcct gtggcttcag     1080

gcaaacagca gcagctccga ggctgtcata tgaaagccat cacttcttcc tggcagtgtt     1140

ggcctgagaa gagctgtagc atttataatg gcccagcaca cagtaggtgc tggaaattct     1200

gtatttatta tcactattaa ctcctttcct agaatatgga gatgagttac tgtgtgttct     1260

gttcctgaga gcagtgtctc tgatcttcag agatcattcg tctcgggtgt tcattctcaa     1320

tttggtaaag gaccgccatg cacgattgcg tcatccttcc tttacattct ttccagtttt     1380

ttatcttcag tcgttgacag tcagttgtgt tctctgggct actcttagta atttctaata     1440

tgtcatagta ggttgtctct taaatcagaa gtgatttttt gtcacctctt atacaatttt     1500

aattacagat ttgatagtca ttttacctta tatatataaa tatttttcat gtgcacacat     1560

cattttataa gaactcttga agataaaggc ccactgaaag tgttggtggt ctcagcccat     1620

tgaactggac gagaactggc ccaggttgct ggaaacaagt gaagcaacca ttacaatgtg     1680

ccttgtgtta tcttgtaaag tagccagtga aggttaagtt tcagcgttca gtgctcaggt     1740

gttcaaatgc tgcagccttc agcttcatgg aaaaaggaaa cgaaaaataa caaaaagcaa     1800

gtgaccaaga gcagtcgggg cagggagacc tgatcaaaca agttcctcag tttctaattc     1860

agtgtctccc acagagagat ggaactttac aaggcagatt catagctctg tcccactgga     1920

cgttgggtcc gctgccctgt ggccatccca cctccccaca aatactgttt tttgttttat     1980

ccttggttca tcccaactgc tgcctcctcg tcctgagccc tcatcgctcg gaacgccccg     2040

ctctgatccc cgtgtctgct tttctgagca cactcttgcc cgcccccgca tgtcctgccc     2100

gttcctactg gttccctctg ccttgcttaa aatgtgccag tttttcaaag cctagctgaa     2160

gctttcttcc aatttctttg gtcttctcta aacctctatt gtatgtttaa acaacaccat     2220

ctaagagatc aagaagaaca gaagtatgaa tgctattcta                           2260


<210> 2282
<211> 1746
<212> DNA
<213> Homo sapiens

<400> 2282
tatattttga atacatctgt cttcataaaa tacaccatgt ccaaaatcta aaagggccaa       60

ttccaaatta ttccaccagc tttgaaggga attgaagcaa gaataacaag acagaagaat      120

agaaggaagg tgataggatg tgatgataga atttgtgata gccaagcaac aacttttcct      180

aattcggcat gttaaaaaat aagggtcact catctaagaa agataacttg gcagtcaatg      240

cagttgcttt acaagatcac attttacatg atcttcaact tcgaaatctt tcagttgcag      300

atcattctaa gacacaagta caaaagaaag agaacaaatc tctaaaaaga gatacaaagg      360

caataataga tactggactt aaaaaaacta cacagtgccc caaactagaa gactcagaaa      420

aagaatatgt tcttgatccc aaaccgccgc cgttgacttt ggcacagaag ttgggcctca      480

ttgggcctcc accacctcca ctgtcatcag atgaatggga gaaggtgaaa cagcgctctc      540

tcctgcaagg ggactccgtg caaccatgcc ccatctgtaa agaagaattc gagcttcgtc      600

ctcaggtgct gctttcatgc tcccatgtgt tccacaaagc atgtcttcag gcttttgaaa      660

agttcacaaa taagaaaacc tgtcctctct gtagaaagaa ccagtatcaa acccgagtga      720

tacacgatgg ggcccgcctg ttcagaatca agtgtgtgac cagaatccaa gcctactgga      780

gaggatgtgt tgttagaaag tggtacagaa acctgaggaa aacagtacct cccacagatg      840

ccaagttaag aaaaaaattc tttgaaaaaa agttcacaga aatcagccac cgcatcctgt      900

gctcatacaa caccaacatt gaagagctct ttgcagaaat cgatcagtgc ttggccataa      960

atcgaagtgt tcttcagcag ttggaagaaa aatgtggcca tgagatcaca gaagaggaat     1020

gggagaaaat ccaagtgcag gctctgcgcc gggagaccca cgagtgctcc atctgcctgg     1080

cccctctctc cgctgctggc ggtcagcgcg tgggtgcagg caggcgttcc agagagatgg     1140

ccctcctgtc ctgctcacat gtgttccacc atgcgtgtct gctggcacta gaggagttct     1200

ccgtgggaga caggcctcct ttccatgcct gtcctctctg ccgctcctgc taccagaaga     1260

agattcttga atgttgaatt catagtcaag gaaagttagg taattctgag gaaaaaagtt     1320

taccatcatt ttggatgaac tgcatgagtt ctgggttaag tactacaatg taatctgttt     1380

cccagggaaa taagctattg gtagttgtag gaaatcttag tatattttaa aagctgacat     1440

cccacctaat tttaatcttt ggtctctaaa aagtaaattt caaatttatg agtttaatca     1500

cttcaaatat gaatagcaaa aaatgagagc ttgcttactt ctaaaaattg aggttaagat     1560

atagctagtg tctgaacgac actccttaaa gtaagttcca aatgtaaaac actccttaag     1620

ttccaaatgt tttccgctaa tagtctgtcc taaagccttt gccattccta atactcgttt     1680

tgtaataatt gctgtatttc tgtgtaataa aatataaaaa taaaatattc agtggtattc     1740

aacatc                                                                1746


<210> 2283
<211> 2171
<212> DNA
<213> Homo sapiens

<400> 2283
agaagagccc tgggctgggt ggggcagggc ggaagggccc tggccttgtt gggtggaggt       60

gaagagttaa tggctccgcg cgcaggcact gccctctgaa ctggaacaaa atgcaacttc      120

cggttggagt cactcggcca ggcgccggcg acctgagggg agagggaacg cagctgaaag      180

cgtgaactgt acctgtcatt tactccatcc tttatagtga tgctacagga cgaagaggaa      240

tggataaaaa cattggcgag caactcaata aagcgtatga agccttccgg caggcatgca      300

tggatagaga ttctgcagta aaagaattac agcaaaagac tgagaactat gagcagagaa      360

tacgtgaaca acaggaacag ctgtcacttc aacagactat tattgacaag ctaaaatctc      420

agttacttct tgtgaattcc actcaagata acaattatgg ctgtgttcct ctgcttgaag      480

acagtgaaac aagaaagaat aatttgactc ttgatcagcc acaagataaa gtgatttcag      540

gaatagcaag agaaaaacta ccaaaggtaa gaagacaaga ggtttcttct cctagaaaag      600

aaacttcagc aaggagtctt ggcagtcctt tgctccatga aaggggtaat atagagaaga      660

ctttctggga tctgaaagaa gaatttcata aaatatgcat gctagcaaaa gcacagaaag      720

accacttaag caaacttaat ataccagaca ctgcaactga aacacagtgc tctgtgccta      780

tacagtgtac ggataaaaca gataaacaag aagcgctgtt taagcctcag gctaaagatg      840

atataaatag aggtgcacca tccatcacat ctgtcacacc aagaggactg tgcagagatg      900

aggaagacac ctcttttgaa tcactttcta aattcaatgt caagtttcca cctatggaca      960

atgactcaac tttcttacat agcactccag agagacccgg catccttagt cctgccacgt     1020

ctgaggcagt gtgccaagag aaatttaata tggagttcag agacaaccca gggaactttg     1080

ttaaaacaga agaaacttta tttgaaattc agggaattga ccccatagct tcagctatac     1140

aaaaccttaa aacaactgac aaaacaaagc cctcaaatct cgtaaacact tgtatcagga     1200

caactctgga tagagctgcg tgtttgccac ctggagacca taatgcatta tatgtaaata     1260

gcttcccact tctggaccca tctgatgcac cttttccctc actcgattcc ccgggaaaag     1320

caatccgagg accacagcag cccatttgga agccctttcc taatcaagac agtgactcgg     1380

tggtactaag tggcacagac tcagaactgc atatacctcg agtatgtgaa ttctgtcaag     1440

cagttttccc accatccatt acatccaggg gggatttcct tcggcatctt aattcacact     1500

tcaatggaga gacttaagac acatttgaaa acagacatat caagttctat gtgatgattt     1560

tgggttttta atactataaa tacttgattg taaactaaat tcaagatcat ttataggaaa     1620

atctagtttc acagctattt gaattttttt ctggatttac tatataactc ttatttttta     1680

aaagatcatt ctgttctttc aaggagaaat aagcctaaaa gaagaaaaac aaaaaaaatt     1740

ctgtataaaa ctgtaatcct ttgtattcat gtttacagtg ctattactat aattcaaaat     1800

tatgtatgtg acttagagtt atataatcat aatttatgtt tatttcaaat atctaagttt     1860

attgcttgga tttctagtga gagctgttga atttggtgat gtcaaatgtt tctagggttt     1920

ttttagtttg tttttattga aaaatttaat tatttatgct ataggtgata ttctctttga     1980

ataaacctat aatagaaaat agcagacaac ataaacatct ttgtaaatat caaacctaat     2040

acatttcttg tccagtgata aaacaactgg tagaattatt taaacacttt agatttttaa     2100

ataatataca tggctttaat ttttactgtg tgtatagcta catgatgaaa ttaattaaat     2160

attaagaggt a                                                          2171


<210> 2284
<211> 840
<212> DNA
<213> Homo sapiens

<400> 2284
cgcggagctg aggagcaggg ccgggcgcca tggcaccgtg gggcaagcgg ctggctggcg       60

tgcgcggggt gctgcttgac atctcgggcg tgctgtacga cagcggcgcg ggcggcggca      120

cggccatcgc cggctcggtg gaggcggtgg ccagactgaa gcgttcccgg ctgaaggtga      180

ggttctgcac caacgagtcg cagaagtccc gggcagagct ggtggggcag cttcagaggc      240

tgggatttga catctctgag caggaggtga ccgccccggc accagctgcc tgccagatcc      300

tgaaggagca aggcctgcga ccatacctgc tcatccatga cggagtccgc tcagaatttg      360

atcagatcga cacatccaac ccaaactgtg tggtaattgc agacgcagga gaaagctttt      420

cttatcaaaa catgaataac gccttccagg tgctcatgga gctggaaaaa cctgtgctca      480

tatcactggg aaaagggcgt tactacaagg agacctctgg cctgatgctg gacgttggtc      540

cctacatgaa ggcgcttgag tatgcctgtg gcatcaaagc cgaggtggtg gggaagcctt      600

ctcctgagtt tttcaagtct gccctgcaag cgataggagt ggaagcccac cagttacttt      660

cagtatgaaa gcaagaagca gaaatgcctg cggcttttcc tgagtttttg ctgcttctct      720

gaaaggataa gaattgacaa gtcctatcag tgtgttaata tatctcactg gcaagacagt      780

gtaacagcaa gattacaaca atatggagga aataataaag tcactcattt tgcgaccttt      840


<210> 2285
<211> 3517
<212> DNA
<213> Homo sapiens

<400> 2285
gggcccgttc tccgggcctg gggggcgcgc gcccctgggg tcccggcgct gcccgctgtg       60

gtgtccccgg caggcagagc gcgatccagg ccgggacgac ttgggaaagt tctaagtaaa      120

gtttgatcag ccggtttgat cggtctgacg tggtccaaga gtctgaccca agggtttgcg      180

actgggagag gaaatctgtg tcctggacaa gattggatta tggaagtggg aagtgaagaa      240

gaaaaatggg agaagctgga tgcagaattt gatcactttg tggttgatat gaagcccttt      300

gttctaaaat tacctcatag gacagaacgg cagaggtgtg ctctttggat tagaaagctg      360

tgcgaacctt caggaacagg tgcaggaata atggggagga agaatcggaa cctgtatgca      420

aaattgttat tgcatatgct taaacgaggt gcgcttgaag gcccttttac acaccgacct      480

gaacccggga cactaaaaat tctaccttca tacatgtcca tctattttga tgaaccaaat      540

ccagcacgag caaaaggttc aagcccagag ggattaccag cctgggtact gggtgagctg      600

gagacaagtg aacacaaatt aaatgaatca tggaaactct cttctggaga agataacact      660

ttagtacagt cgccaactga tgtctacagc agggaacagt acactgggaa gctccgagtg      720

agatcacact ccttgagtcc aactcacaga gaagatggac aaaatattac cccaaagatt      780

tgtgaagttt attcgaaaaa atctcctgtt tctttggatg atagtgacat tgaagctcgc      840

cttaatagtt ggaatcttgg gatagaaaat cctcgatacc tgagacagaa gcctatccca      900

gtttctctga tgacaccgaa attcagcctg agaaaatcca gcagtttcca tgatgatcat      960

tttctctctc gaatacgtga gaaagagctg gacatgaaaa caaaaatgat ggaagctaaa     1020

tttcatgaag aaaagcttaa actgcaacag aaacatgatg ctgatgttca gaagatttta     1080

gaaagaaaga ataatgaaat agaagaactg aaaactttat acaggagtaa acaacatgaa     1140

actgaagaga ctattagaaa gcttgaaaag aaagttcaga cactgatacg tgactgtcaa     1200

gttatcagag agactaaaga agaccagatt gcagagctga aaaagatatg tgaacaaagt     1260

acggaatctc taaataatga ctgggaaaaa aagcttcaca atgctgtagc agaaatggaa     1320

caggaaaagt ttgatcttca aaagcaacac actgaaaaca ttcaagaatt gcttgaggat     1380

acaaatgtgc gtctgaataa aatggagagt gaatacatgg cgcaaacaca gtccacaaac     1440

cacatgatca aagaactgga ggcccgtgtc cagcagctga ctggagaagc agagaacagt     1500

aatttacaga ggcagaaatt aattcaagaa aaagcagaac ttgaaagatg ttaccagata     1560

acgtgtagtg aattacaaga agtaaaggca aggcgtaaca cactgcataa agagaaggac     1620

catcttgtaa atgattatga gcaaaacatg aaactgttac aaaccaaata tgatgctgat     1680

ataaaccttc taaaacaaga acatgctctt tcagcttcta aggcatctag tatgattgaa     1740

gaattagagc agaatgtctg tcaattaaaa cagcagttac aggaatcaga acttcaaaga     1800

aagcaacaac taagggatca agaaaataag tttcagatgg agaaaagtca tttaaaacac     1860

atctatgaaa aaaaggctca tgacttgcag agtgaacttg ataaaggaaa agaagatact     1920

caaaagaaaa ttcataaatt tgaggaagct ttgaaggaaa aagaggagca gctaactcgt     1980

gtgactgaag ttcagaggtt gcaggcccag caggcagatg ccgctctgga agagtttaag     2040

cggcaggtgg aactgaactc agagaaagtc tatgctgaaa tgaaagagca gatggaaaaa     2100

gtggaggcag atctaactag atccaaatct cttcgtgaga aacaatcaaa ggagttttta     2160

tggcaactgg aggacatcag acagcggtat gaacaacaga tagtagagct gaagctggag     2220

catgaacagg agaagacgca cctattacag cagcataacg cagagaagga tagcctagtc     2280

cgagaccatg aacgggaaat tgaaaacctg gaaaaacagc ttcgcgctgc caatatggag     2340

cacgaaaatc aaattcagga gttcaagaaa cgagatgcac aggttattgc cgacatggag     2400

gcccaggttc acaagttgag agaagaattg atcaatgtga actcacagcg gaaacagcag     2460

ctggtagagc ttggtcttct tcgtgaagag gaaaagcaaa gggctacaag ggaacatgag     2520

attgtcgtca ataaactgaa ggctgaatca gaaaagatga aaatagagct gaaaaagact     2580

catgctgctg agacagagat gacactggaa aaggccaaca gcaagctgaa gcagattgag     2640

aaggaataca ctcagaagct tgccaaatct tcacagatca tagcagaact tcagacaacc     2700

atttcctctc tgaaagaaga gaacagccag cagcagcttg ctgcagaaag gcggctccag     2760

gatgttagac aaaagtttga agatgagaag aagcagctga ttagagataa tgaccaagca     2820

atcaaggttt tacaagatga attagaaaac cgttctaatc aggtgcgatg tgcagagaaa     2880

aaattacaac acaaagaatt ggagtcacag gaacagataa cttacatacg acaagaatat     2940

gaaacaaaat tgaaaggatt gatgccagca tccctaagac aagaacttga agacaccatt     3000

tcctccctaa aatcacaggt taattttctg caaaagagag cttccatcct tcaggaagaa     3060

ctgactacat atcaaggcag aaggtaactg cacgagagaa tgcaacggat gcaatttcca     3120

ggctgtgctg tggacttctt ccagcaggtt tgaagatttg gatattgtaa actgtgagat     3180

cagtggcatt ttttaaatcc ttaaatgtaa ttaagatcat aaaaacatgc atcattcata     3240

cactagtggg gtggttttat ttgtgtctgc ctaagttatt tttttaacat tcctttattt     3300

ccgattttca tgtttgtgtg catttgagta tgtgctgaga actgcttata ttgggcaaag     3360

tgatttccta tgatatgcct tgttaatcct tttgcataga attttaccag ttgcgtacga     3420

tcaaaatcac gtttgtagta tcatatcaaa aattctaacc tgtttacatt gttttcatgt     3480

tcatgttcct atgttattaa aatattattt tgtactt                              3517


<210> 2286
<211> 1379
<212> DNA
<213> Homo sapiens

<400> 2286
taggcgccat tttcgagtga aggacccgga gccgaaacac cggtaggagc ggggaggtgg       60

gtactacaca accgtctcca gccttggtct gagtggactg tcctgcagcg accatgcccc      120

gtaaaggcac ccagccctcc actgcccggc gcagagagga agggccgccg ccgccgtccc      180

ctgacggcgc cagcagcgac gcggagcctg agccgccgtc cggccgcacg gagagcccag      240

ccaccgccgc agagactgca agtgaggaac ttgataatag aagtttagaa gagattttga      300

acagcattcc tcctcccccg cctccagcaa tgaccaatga agctggagct cctcggctta      360

tgataactca tattgtaaac cagaacttca aatcctatgc tggggagaaa attctgggac      420

ctttccataa gcgcttttcc tgtattatcg ggccaaatgg cagtggcaaa tccaatgtta      480

ttgattctat gctttttgtg tttggctatc gagcacaaaa aataagatct aaaaaactct      540

cagtattaat acataattct gatgaacaca aggacattca gagttgtaca gtagaagttc      600

attttcaaaa gataattgat aaggaagggg atgattatga agtcattcct aacagtaatt      660

tctatgtatc cagaacggcc tgcagagata atacttctgt ctatcacata agtggaaaga      720

aaaagacatt taaggatgtt ggaaatcttc ttcgaagcca tggaattgac ttggaccata      780

atagattttt aattttacag ggtgaagttg aacaaattgc tatgatgaaa ccaaaaggcc      840

agactgaaca cgatgagggt atgcttgaat atttagaaga tataattggt tgtggacggc      900

taaatgaacc tattaaagtc ttgtgtcgga gagttgaaat attaaatgaa cacagaggag      960

agaagttaaa cagggtaaag atggtggaaa aggaaaagga tgccttagaa ggagagaaaa     1020

acatagctat cgaatttctt accttggaaa atgaaatatt tagaaaaaag aatcatgttt     1080

gtcaatatta tatttatgag ttgcagaaac gaattgctga aatggaaact caaaaggaaa     1140

aaattcatga agataccaaa gaaattaatg agaagagcaa tatactatca aatgaaatga     1200

aagctaagaa taaagatgta aaagatacag aaaagaaact gaataaaatt acaaaattta     1260

ttgaggagaa taaagaaaaa tttacacagc tagatttgga agatgttcaa gttagagaaa     1320

agttaaaaca tgccacgagt aaagccaaaa ctggagaaac aacttcaaaa agaaaaaaa      1379


<210> 2287
<211> 508
<212> DNA
<213> Homo sapiens

<400> 2287
gcataggtga taaaatcatg gtggggagag agaacctata tattgagtcc tggcttgatg       60

cctttggtgt atatgtctgc cgccttttaa tctcttcccc tctagattgc ttcctgagga      120

ggctggcact tctgaagatc ctgaagaccc taaaggagat tcacaggcag gtacccccag      180

cactttagcc ctgtgtggcc agcgccccat gcgcaagcgt ctttctgccc cagagttgcg      240

gctgagtctg actaaggggc ctggaaatga tggagcttca cccacccagt ctgcaccttc      300

ctctcctgat ggcagttctg acctggagat agacgaattg gagacacctt cagactcgga      360

gcagctggac agtggacatg aatttgaatg ggaagatgaa ctaccccggg cagagggtct      420

gggcaccagt gagacagctg aaaggctggg ccgaggttgt atgtgggatg tgactggaga      480

agatggacat cactggaggg tgttccga                                         508


<210> 2288
<211> 2678
<212> DNA
<213> Homo sapiens

<400> 2288
atgggtaaag ttgaaaattc taagagtgcc cagggtctgg ctggtcttcg aaaccttggg       60

aacacgtgct tcatgaactc aattctgcag tgcctgagca acactcggga gttgagagat      120

tactgcctcc agaggctcta catgcgggac ctgcaccacg gcagcaatgc acacacagcc      180

ctcgtggaag agtttgcaaa actaattcag accatatgga cttcatcccc caatgatgtg      240

gtgagcccat ctgagttcaa gacccagatc cagagatacg caccgcgctt tgttggctat      300

aatcagcagg atgctcagga gttccttcgc tttcttctgg atgggctcca taacgaggtg      360

aaccgagtga cactgagacc taagtccaac cctgagaacc tcgatcatct tcctgatgac      420

gagaaaggcc gacagatgtg gagaaaatat ctagaacggg aagacagtag gatcggggat      480

ctctttgttg ggcagctaaa gagctcgctg acgtgtacag attgtggtta ctgttctacg      540

gtcttcgacc ccttctggga cctctcactg cccattgcta agcgaggtta tcctgaggtg      600

acattaatgg actgcatgag gctcttcacc aaagaggatg tgcttgatgg agatgaaaag      660

ccaacatgct gtcgctgccg aggcagaaaa cggtgtataa agaagttctc catccagagg      720

ttcccaaaga tcttggtgct ccatctgaag cggttctcag aatccaggat ccgaaccagc      780

aagctcacaa catttgtgaa cttcccccta agagacctgg acttaagaga atttgcctca      840

gaaaacacca accatgctgt ttacaacctg tacgctgtgt ccaatcactc cggaaccacc      900

atgggtggcc actatacagc ctactgtcgc agtccaggga caggagaatg gcacactttc      960

aacgactcca gcgtcactcc catgtcctcc agccaagtgc gcaccagcga cgcctacctg     1020

ctcttctacg aactggccag cccgccctcc cgaatgtagc gccaggagcc acgtcccttc     1080

tcccttcccc gtggtggccc cgctccctaa attttttaaa aagacaaaaa caaaacaaca     1140

acaacaacac acaaacctga caagagaaaa acaaacctga agctgccgag caggagtgga     1200

tgcagcctga tcagggtctg gagcaaggag ccgggctttc ctgagctgtg gcccggcagg     1260

gaagatcgcc tggacgtgga gccagcatcg ccccgtgccc tcggcgtttg catttgtaaa     1320

cttgtggtct tcctatgtgt cagaaacaac tgtgtcttgg gggggaagac cctcgctgcg     1380

ccgcttcccg ccgcagcgcc cgcgcctccg aggggacagc gccctctgga gctcgctggg     1440

agcatcaccg cctggacgcc cgcgccgcgg aggagccggc gcccatctcc acccgcacgg     1500

ctcgccggtc cagagccatg agccaagagc cctcttcacg ctgctaactc caggggacag     1560

acgaagggac atctttggaa aacgctggtt ttggttttta aaaagcccaa cttttttttt     1620

ttaatttcca taactaaagt gttcagactg gagtgctctc cttcaggcct cttcatagct     1680

gggacgttgc actggtcctt ttattgcttt tccaagtaca actttctaat gctagccctc     1740

cgtggtgcta ggtgggcgtt ggccaggccc caagcacagc cacagtagac ctgggatcta     1800

aaacaagttt ctgttttggg ggtttgggtt tttttttttt ttttttaatg ttttgaatgg     1860

aatttagttg cctccaagaa ttgtgcctta tagcatttgg ggaccagggg gtaactgccc     1920

ctcctgaaat atccctcagc ctcttccctt ttccccagtg ctctgttcaa acccgcctgg     1980

gaaagggatc ctgcccttag ccctggctcg ttgtgcattg cagtgaggca aagaagaaag     2040

caggtagatt ccttccgaca gggcatcaag ttcttcccgc ccacgtcctc tagcccaccc     2100

ctggtctgct ccccagctgt ttgaaggata gcacaagccc ctcgtcccta gagcttctct     2160

cccttttatt tattctctta acatcccttt ccccctggcc ttcctgcccc cgcccccttc     2220

tcagagcctc ctagacaata ggccctttgg accgagtttc tcagggatgc ccaggccacc     2280

cctcagctct tcttagcgct ggtctccagt cctgccctgg gagctggagc ctgggtattt     2340

ggggacatct tgcctcagtt gtatggttct ttcctgtggg ctcaattttg ccctacatag     2400

ttggataaaa ctctgtgctg tcctggagag taaagctgtt cacccacaca gctgggcccg     2460

gcttgtgccc cgtggagcct ggcacattcc aggctcctag gaggaggcat cagagaaaga     2520

caccctgagt tttactggcc tgacaccctt ctccagagaa gacctgtgaa cctgagccca     2580

agggcaagtg tacacttgtt tactgtgtaa gcaagagtag aagaatgtct aatgtacagt     2640

ggaaccttgt acagaataaa taatagcttt gagaaatc                             2678


<210> 2289
<211> 2190
<212> DNA
<213> Homo sapiens

<400> 2289
gcgtgctagg aggcgaggcg aggggcatgc gtgctaggag gcgaggcgag gggcatgcgt       60

gctaggaggc gaggcgaggg gcatgcgtgc taggaggcga ggcgaggggc atgcgtgcta      120

ggaggcgagg cgagggccag gtgctagggc tagaaaggag gcagggctgg cgctctaggg      180

actcctggag ctctcctcct gtgagcctgg acccggcacc tcacgcagcc catctcccac      240

agcttccgtc gacggaggcc ggggcctcac caggaaagtg gtttgccctc caatcagtgg      300

tctgccttca ttttccagat tgatgaagtc tgcctcagag aaggggcaat aggcgaatat      360

gaagacctta gagcagagaa ccagaaaaca aaggagaagt gtgacaaaat taggcaagaa      420

cgagatgaag ccgttaaaaa actggaagaa tttcagaaaa tttctcacat ggtcatagag      480

gaagttaatt tcatgcagaa ccatcttgaa atagagaaga cttgtcgaga aagtgctgaa      540

gctttggcaa caaagctaaa taaagaaaat aaaacgttga aaagaatcag catgttgtac      600

atggccaagc tgggaccaga tgtaataact gaagagataa acattgatga tgaagattcg      660

actacagaca cagacggtgc cgccgagact tgtgtctcag tacagtgtca gaagcaaatt      720

aaagaacttc gagatcaaat tgtatctgtt caggaggaaa agaagatttt agccattgag      780

ctggaaaatc tcaagagcaa actcgtagaa gtaattgaag aagtaaataa agttaaacaa      840

gaaaagactg ttttaaattc agaagttctt gaacagagaa aagtcttaga aaaatgcaat      900

agagtgtcca tgttagctgt agaagagtat gaggagatgc aagtaaacct ggagctggag      960

aaggaccttc gaaagaaagc agagtcattt gcacaagaga tgttcattga gcaaaacaag     1020

ctaaagagac aaagccacct tctgctgcag agctccatcc ctgatcagca gcttttgaaa     1080

gctttagacg aaaatgcaaa actcacccag caacttgaag aagagagaat tcagcatcaa     1140

caaaaggtca aagaattaga agagcaacta gaaaatgaaa cactccacaa agaaatacac     1200

aacctcaaac agcaactgga gcttctagag gaagataaaa aggaattgga attgaaatat     1260

cagaattctg aagagaaagc cagaaattta aagcactctg ttgatgaact ccagaaacga     1320

gtgaaccagt ctgagaattc agtacctcca ccacctcctc ctccaccacc acttccccct     1380

ccacctccca atcctatccg atccctcatg tccatgatcc ggaaacgatc ccaccccagt     1440

ggcagtggtg ctaagaaaga aaaggcaact caaccagaaa caactgaaga agtcacagat     1500

ctaaagaggc aagcagttga agagatgatg gatagaatta aaaagggagt tcatcttaga     1560

cccgttaatc agacagccag accgaagaca aagccagaat cttcgaaagg ctgcgaaagt     1620

gcagtggatg aactaaaagg aatactgggg acacttaaca aatccactag ttcaagaagc     1680

ttaaaatccc ttgaccctga aaacagtgaa actgagttag aaaggatttt gcgtcgcaga     1740

aaggtgacag cagaagcaga tagcagtagt ccaactggga tattagccac ctcagagtcc     1800

aaatccatgc cagtgttggg ttctgtatcc agtgtaacaa aaacagcctt gaacaagaaa     1860

actctggagg cagaattcaa cagcccgtcc cccccaacac ctgagccagg tgaagggccc     1920

cgtaaattgg aaggatgcac aagttccaag gttacgtttc aataatctga atcagaaaat     1980

actgcaactc cttcctcctt ttgtctgcct tttgttctcc aaaagtaagt ggaaattaca     2040

tttccaagaa aggaaatgaa ataattgcag gcccaaggtc tgcaaaatat gtgttgaatt     2100

gacagtgaaa aggatccatg tgttgacaga cacagttgtt agatgccata aaggcagatg     2160

tgaagctcaa tttatttctc atcttgcttg                                      2190


<210> 2290
<211> 2448
<212> DNA
<213> Homo sapiens

<400> 2290
attgcgtccc gctctacctc tgtggttctt tgggagcgac ccccgggaag cgtccaaagt       60

ggagttccca cacacgctgc gaacccacag ccggttttct ctgaactcgc gtccctgagt      120

ccgggaggtg gaggcggaga aaagggtgcg gagcgacccc acgcagggcc gccccccctc      180

ccaccagcgc gtcctgccgc gccggcagcc acaggctggc atagcggctg ccgacccgcc      240

ctcgttcctc caccccctga acgggactgc tgggcccgcc ccgccccgcc tgcaggtgaa      300

gcggccgcag ccgccgagta ggtgcgtggg gatgatctca ctcgcgcgct ccgcgccagg      360

aggaggagga gcgggagcgg atccaacttc cgggtagtgg agccgcaagc caccggcatc      420

ttgctttttc ttccccctcc tcctgtgtgc cccgcgccgc tccctctttc ccttttattc      480

ccggccccac ccgccaaaat gaacagctcg gacgaagaga agcagctgca gctcattacc      540

agtctgaagg agcaagcaat aggcgaatat gaagacctta gagcagagaa ccagaaaaca      600

aaggagaagt gtgacaaaat taggcaagaa cgagatgaag ccgttaaaaa actggaagaa      660

tttcagaaaa tttctcacat ggtcatagag gaagttaatt tcatgcagaa ccatcttgaa      720

atagagaaga cttgtcgaga aagtgctgaa gctttggcaa caaagctaaa taaagaaaat      780

aaaacgttga aaagaatcag catgttgtac atggccaagc tgggaccaga tgtaataact      840

gaagagataa acattgatga tgaagattcg actacagaca cagacggtgc cgccgagact      900

tgtgtctcag tacagtgtca gaagcaaatt aaagaacttc gagatcaaat tgtatctgtt      960

caggaggaaa agaagatttt agccattgag ctggaaaatc tcaagagcaa actcgtagaa     1020

gtaattgaag aagtaaataa agttaaacaa gaaaagactg ttttaaattc agaagttctt     1080

gaacagagaa aagtcttaga aaaatgcaat agagtgtcca tgttagctgt agaagagtat     1140

gaggagatgc aagtaaacct ggagctggag aaggaccttc gaaagaaagc agagtcattt     1200

gcacaagaga tgttcattga gcaaaacaag ctaaagagac aaagccacct tctgctgcag     1260

agctccatcc ctgatcagca gcttttgaaa gctttagacg aaaatgcaaa actcacccag     1320

caacttgaag aagagagaat tcagcatcaa caaaaggtca aagaattaga agagcaacta     1380

gaaaatgaaa cactccacaa agaaatacac aacctcaaac agcaactgga gcttctagag     1440

gaagataaaa aggaattgga attgaaatat cagaattctg aagagaaagc cagaaattta     1500

aagcactctg ttgatgaact ccagaaacga gtgaaccagt ctgagaattc agtacctcca     1560

ccacctcctc ctccaccacc acttccccct ccacctccca atcctatccg atccctcatg     1620

tccatgatcc ggaaacgatc ccaccccagt ggcagtggtg ctaagaaaga aaaggcaact     1680

caaccagaaa caactgaaga agtcacagat ctaaagaggc aagcagttga agagatgatg     1740

gatagaatta aaaagggagt tcatcttaga cccgttaatc agacagccag accgaagaca     1800

aagccagaat cttcgaaagg ctgcgaaagt gcagtggatg aactaaaagg aatactgggg     1860

acacttaaca aatccactag ttcaagaagc ttaaaatccc ttgaccctga aaacagtgaa     1920

actgagttag aaaggatttt gcgtcgcaga aaggtgacag cagaagcaga tagcagtagt     1980

ccaactggga tattagccac ctcagagtcc aaatccatgc cagtgttggg ttctgtatcc     2040

agtgtaacaa aaacagcctt gaacaagaaa actctggagg cagaattcaa cagcccgtcc     2100

cccccaacac ctgagccagg tgaagggccc cgtaaattgg aaggatgcac aagttccaag     2160

gttacgtttc agcctcccag tagcattgga tgcaggaaaa aatacattga cggtgaaaaa     2220

caagccgaac cagttgtagt tttagatcct gtttctacac atgaacccca aaccaaagac     2280

caggttgctg aaaaagatcc aactcaacac aaggaggatg aaggcgaaat tcaaccagaa     2340

aacaaagaag acagcattga aaactttttc ccttttcact ttggttttga gggggttttg     2400

cccctggctg gggtgacact gtcaaccaaa gcaagggatc ccaaatag                  2448


<210> 2291
<211> 1307
<212> DNA
<213> Homo sapiens

<400> 2291
agttttcaca aaggtctctt gatatcaaaa cttctttcct tgcatgcttc tctgatcctg       60

tggagatgaa aattgacatc catagtcata ttctaccaaa agaatggcca gatctaaaaa      120

agaccctgag acaaggattc agatgcaagt agtttgcttt ggaggtgatc ccaggaaaca      180

ccagtagagt gaggaagtga gacagggaaa acagggcagc cagtgaaaga ggtttggcta      240

cggaggctgg gtgcagctcc aacaccacag caagggagaa gcaaagttgt tgaaagatgg      300

gaaagtcttc agagtggtgc gagagaattg ctgggatcca gaagttcgta ttagagaaat      360

ggaccaaaaa ggccaaacct gaggacactt taaacctgtg ccagctttta aacaacgacc      420

ttgccagcac cgttgtgagc taccccagga ggttcgtggg tctggggacg ttgcccatgc      480

aggcccctga gctggcggtc aaggagatgg agcgctgtgt gaaagagctg ggctttcccg      540

gggtccaaat tggcacccac gtcaacgagt gggacctgaa cgcgcaggag ctctttcctg      600

tctatgcggc agccgaaagg ctgaagtgtt ccctgttcgt gcatccctgg gacatgcaga      660

tggatggacg aatggccaaa tactggctcc cttggcttgt aggaatgcca gcagagacca      720

ccatagccat ttgctccatg atcatgggtg gagtatttga gaagtttccc aaactgaaag      780

tgtgtttcgc acatggtggt ggtgccttcc ccttcacagt gggaagaatc tcccatggat      840

tcagcatgcg cccagatctg tgtgcccagg acaaccccat gaacccgaag aaataccttg      900

gttcctttta cacagatgct ttggttcatg atcctctgtc cctcaagctg ttaacagatg      960

tcataggaaa ggataaagtc attttgggaa ccgattaccc ctttccacta ggtgagctgg     1020

aacctgggaa actaatagag tccatggaag aatttgatga agaaacaaag aataaactca     1080

aagccggcaa tgccctggca tttttgggtc ttgagagaaa acaatttgaa tgactgaatt     1140

tactacaaag gcaaactttc aaaaggatat ctcatttttg tttctaaata tgtatcaaca     1200

ggtatcaaca aaatcctatt ttgaactatt ttactcagaa atgaatgtcc caaatatcct     1260

aaattattca taataaaaat gatttgtaag tgttttcatt ctgaaaa                   1307


<210> 2292
<211> 6841
<212> DNA
<213> Homo sapiens

<400> 2292
aaagcgagga gaggaggcgt gagagagcgt gcctgcccgc cgcacacggg gctggtttcc       60

ggagtgcgtc tctagaggga tgcacgttgc cttagccgag cttcggagag aagcctgata      120

tgtaacccag gcaggtggga gcctcagtct gtcgggctga ggtctggcat ctacaaagcc      180

tcttggccgt gttctgaact tgaagcctgg aggagttctc tgctcagcac agccaaggaa      240

cagaattaga agaaaaggaa ccctggcctg aggcaggtga caaacattac caccccagct      300

gtgcacgatg cagcagatgc aaccagatgt tcacagaagg agaggaaatg tatcttcaag      360

gctccaccgt ttggcatccc gactgtaagc aatctacgaa gaccgaggaa aagctgcggc      420

tgccaaacat tcggcgttct tcatccgatt tcttttattc caaaagtctg attcgacgca      480

caggacggtc tccgtctctg cagcctacca ggacatcctc ggaaagtatt tattctaggc      540

caggctccag tattcctggc tcaccaggtc atactatcta tgcaaaagta gacaatgaga      600

tcctggatta caaggattta gcagccattc cgaaggtcaa ggcaatttat gacattgaac      660

gtccagatct tattacctat gagcctttct acacttcggg ctatgatgac aaacaggaga      720

gacagagcct tggagagtct ccgaggactt tgtctcctac tccatcagca gaagggtacc      780

aggatgttcg ggatcggatg atccatcggt ccacgagcca gggctccatc aactcccctg      840

tgtacagccg ccacagctac actccaacca cgtcccgctc tccccagcat ttccacagac      900

ctgatcaagg aatcaacatt taccgaaagc cacccatcta caaacagcat gctgccttgg      960

cagcccagag caagtcctca gaagatatca tcaagttttc caagttccca gcagcccagg     1020

caccagaccc cagcgagaca ccaaagattg agacggacca ctggcctggt cccccctcat     1080

ttgctgtcgt aggacctgac atgaaacgca gatctagtgg cagagaggaa gatgatgagg     1140

aacttctgag acgtcggcag cttcaagaag agcaattaat gaagcttaac tcaggcctgg     1200

gacagttgat cttgaaagaa gagatggaga aagagagccg ggaaaggtca tctctgttag     1260

ccagtcgcta cgattctccc atcaactcag cttcacatat tccatcatct aaaactgcat     1320

ctctccctgg ctatggaaga aatgggcttc accggcctgt ttctaccgac ttcgctcagt     1380

ataacagcta tggggatgtc agcgggggag tgcgagatta ccagacactc ccagatggcc     1440

acatgcctgc aatgagaatg gaccgaggag tgtctatgcc caacatgttg gaaccaaaga     1500

tatttccata tgaaatgctc atggtgacca acagagggcg aaacaaaatc ctcagagagg     1560

tggacagaac caggctggag cgccacttag cccctgaagt gtttcgggaa atctttggaa     1620

tgtccataca ggagtttgac aggttacctc tttggagacg caacgacatg aagaaaaaag     1680

caaaactctt ctaagtccca ctcgtgaatg gcaattagag aaaggactga cagtggcggt     1740

gccccatagg atgtcatatt gaggcccaaa cttgattgga gaatttgcaa actaccgtcg     1800

ctcagcaaca ccaaaaagag aaagtctggt taaaacacca tgagtcaaat gtcgggccag     1860

ccaacagtaa cacttgccaa gaagcatggc gtagaaattt ctatgttccg aaacacagag     1920

tagtgtccac atgtgagctt ttcacattac cttatgtata caacaggagc tgcgttgttt     1980

tcttcttttt cttttccttt atctgttgtc caacaacagt gctgactgtc cggataagag     2040

ctggcaagtg cccttaggat gccgcatggg aaaaatcggt tatcataatt tcaaagtata     2100

aatatattta ttaagtagcg ctgcggctaa gaaggaagag tgaggggtct gtccatgggg     2160

tggcagtgat ttcacacccg cctttcttga atggcttcgt gttactcagc cgtgccctgg     2220

caggaatgga actccatcag ggaacagggc agctctgttt gaatggggtg aaaaacagca     2280

aaattaattc ttagcaagct ccttgttctc tactgttcac cgggacctgg ctggcaaatg     2340

acttagctat tagtatattt aaaaactgtt caaaagcaaa agagaaggaa caggaatgaa     2400

aggaaacctt cccttaactc tttctgcttc ccatagcagg tctggttcct gctccccgcc     2460

taggacagga gctgtctgga gctccacctt tgcaaagaaa ggaaaaacac aaattgcccc     2520

cagattggcc cagtggcatg ccattaggtg attttgcata ggggccatat cattcatggc     2580

caaaaaaaac caaaaagcaa aaaacaaaaa caagtcccat gtcctactga ctctagttct     2640

tccagtcgtt atcctctgct gtctctctgg catcctatga atcagatcaa gcccatgctg     2700

ttgttggttt ttaaggtttc tttcaataat aggctaagga aagacatgtt tttctctttt     2760

aaatctctgc aactccaaag tagactcctt cgaacgtatt taatttggcc ttttcagctt     2820

tcttcttgcc cagctctgtc gaattcatgg gtgtgtgtgc acatgttggt ttcactcacc     2880

cagagtaatt ttgtgagcat gcatgtgctt tttaatttct gcttgaatgt ttgtcctgct     2940

gtgttgcagc ttctaaagac attgtcaccg agtgtgtgtg actcaaagat caagagtgag     3000

gctaaactgc gaccccaaca tcacttcctt catggaaagg tgttggcgct gatgtagctc     3060

atggaaggat cagactggga accacagagg aaggatgagg tgggatgtgg aggtcagagc     3120

atctcacgag agtccctcag gctctgcaac actagattcg aatatgagcc tagggtttcc     3180

ccaacacgtg cgtgcatatg aaaccacatc atgattcccg acgtgagtta gatgagggag     3240

agtttgtgta actccacacc caggagggta agccacttta ttatcatgct ttggggctgt     3300

gcttaagaat ttaagctctg ttttaaagcc gaagaagaaa acatttgaat ttaccttcat     3360

atgccactaa gaacaaaagc tctgaagttc ttcctgctgg caccaaatat taggattaca     3420

agctgtctct ctgacaccag tggtaaaaaa gcaagtagaa tagtttctga gtctgtgttg     3480

cagcctctga cacgtggctc accgctgtca tttgggggat ggaatgaaca gtcactgttc     3540

tatagcatcc tcctgtgctc ttacctaagg aatctaaatt gtcctagcct tccattgcta     3600

tgcactgaat gaggactact ctcgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     3660

tgtgtgtgtg tgttggatct actaacatgt ttagcaaatg gctctgacag ggtggccatg     3720

agcagatgag accagctctt gcttggttgg aagccacact gcagtttgca gtttagcctt     3780

tggtgtctca gtggcttctt gcttattcca tgctttttct atcccatcct ctctctgtgc     3840

cctcctgcaa tggcagcctt ggcacaatgc ctgggtgtcc tcatccttgc tttactctgg     3900

aaagtgtggg gatggagagg atggtgcatt tccagtgctt ccttacctgt caataacaat     3960

ggtggccacc tgggtcccag cacttggctg gtggagagat ttttttcatt atggagctaa     4020

taaagggtcc ctacgtttta cattgattaa tgaattatca cccagacatg tgcagatgaa     4080

atgtcaatat aagaaaaatc aaggtatttg ggaaacatgg gcataatcag gtagttttgc     4140

taaaattcct cttccttggt ctacataaag aagacatggg tctgtcatag aatggggaca     4200

ttagactgaa aactgggaca acccccttcc ttattttata gagactagga gttaaggggc     4260

ctgcctaaga ttgcagtgat aaagaactga accctaaatc agctcccact aatgaaaccc     4320

tgctttcctt gtatctttta aactcagttc tgcatccaac ttgagaagaa aaaaagcttc     4380

tttccatatc aagtaccata tgagttcatt taaactgcac cttgcagaaa tgcattgcca     4440

gaaagcacca gtagcctcct atctgcaagc agagtagtgc tctgctctgg ggaggggtca     4500

ttggaaacca taatgcagag tgggccccct actccatttc ccagcaaaag gctccagctg     4560

gagggatggg ttgtggggca acctggttcc tgctaactgc cagattgaat gtgtgggcta     4620

gaatgcctgc acatttagtt aaactgggct cagcatgctt gtcctcaaaa tgtccatcct     4680

ggtcacagca cacaagatgg ctattggtct gcttttaccc taccctgtac tatacatgaa     4740

aattccagtt attaacacac tcaaactggt ggagcttgtt caccctagga aggggattgt     4800

atatatggca ggcttccctg gtgccgatgt aaagggctac atttgggaac atttgacttc     4860

cttgggactc ttaagtgcat aatgatggca tgaagtaaaa ggggcctcaa tgatgatagg     4920

aaaatcagtt cttttaaaat ttcttcaaga aaatccaggc tatcacatag tctttctgtg     4980

tgacttatta ggagatagga agagcattgg gaaacttgca cagctagcta tgcatctaca     5040

ttttggtttg gggttagtta tgaaatgttc ttaatatgac gtgttcaata acttcacata     5100

aacttcctgt tctccaaaac ctcaaagaga tagagttaat gagttgttgt ttttttttaa     5160

atgggggtag ttttctatct gtcatgggct ctagcatcta ctccgctacc caattctgtc     5220

atctccaagc tgagtttcct cttctgaggc agaggctgga gcagttcttt ttcagttctc     5280

atcctctcca tcccaatcca gtatatcaat caactctaac tcggagacgt ctagctggca     5340

atgtttctaa aactttcact ggatttcttt agacattgaa gcaaacattt ttttctaaga     5400

attgcttctc agatgatgat atcaaatgta tatgcttttg caagtttgaa aagttcaaat     5460

taaccacttt tgactaggta agtctttcta aaaaccattt aaagctaact gggtcttagc     5520

atcctcctgt gtatggaaga gacaggtgac cgctccaggt tgggtgctca cagaaccctt     5580

ttcctgactc tcatggaaga tggtggaagg aaaatagact gtctcatcaa ccctcctgtg     5640

tcctctgaag caatctcagt ttttattaac cacctcttct gtgtttctgg tagctattta     5700

acctgtattt aatctgtact tcctatgcca gcctcaattt tatttgattt ttacaattat     5760

tctcttctaa ccaatgaagt gtttgtcagt atgccccaaa gcttgctctt ttgtgctccc     5820

ttttgaataa ctttctatcc agaaaaagag attatttggg acttgagatt tgcagtgata     5880

ccaacttata gcaatgatgt actttaaggg aactacccaa ctatgttgtg atagaagaaa     5940

gagaaacctt cactttggca ttttttttta atcactgttt atttttctgt ttgcggccca     6000

ggaagcagtg ggaggtggtg gcagatatgc tttgcatatg gattgttatg tttttatttg     6060

ggcaagttta atcatggaaa actcaaaaag aaggggggaa atggtcagtt taagccaaaa     6120

gaaactttct aaacaatgta taggtacaca gcaaaattaa acaaatccaa caatttctga     6180

agcttagtgt aattgagtgg tggttgttat tcaataaaat tattcccaaa agtgtttctc     6240

ctaagagtgc agttcccatg agtcacttcc tgaacccatt gaccaaaggt ggacagagac     6300

aatcctgtag accttgacat tcagaaagat gtgagctgct tactgatcat atatgcatac     6360

gtttctttac agcagaggaa accattgtcc acaaaactga tgttcttttg gggttttatg     6420

tacagacttg tccaatcatg tgtgtggttc ctgcgagttg ctgatgactc cgcattgaag     6480

ctctctgagt tctttgattt taagttgggt ttatggaatt ttttcaaatg ttggaaggtg     6540

tgtggttctt cctgccctcc ctcccctttt ggaaatatga aagcaaatgt ttagaagaat     6600

tccttttgaa aagctgtgtc gtgttccctg tgaaactgag caggtgtgtg ttggcgcgct     6660

aagtgccaca tgcttgtgtg tagaggagga ggtggccctg ccggctccgc gctgctgtgc     6720

ctgtgatccc tacctgctcc ccgctcctgt tgccagcagc actcactgca ctcctttgtc     6780

atatactctg catcactgtc atactcacaa cttcgtgaat aaagttgtgt gctttattcg     6840

t                                                                     6841


<210> 2293
<211> 7105
<212> DNA
<213> Homo sapiens

<400> 2293
ggtctcatgc tttcatctcc cagtgggtgt gcagacactg gagagaccca gtggcccacc       60

ctcaggaccc tcaccaccca tcagagaagc ctgtcattca ctgccataaa tgtggggagc      120

cttgcaaggg tgaagtgctt cgggtccaga ccaaacattt ccacatcaag tgtttcacct      180

gcaaagtgtg tggctgtgac ctggcacaag ggggcttctt cataaagaac ggagagtatc      240

tctgcaccct ggactaccat cccaattgct ttgcttgtac tatctgcaag cgcccgtttc      300

cacccggaga ccgagtcaca ttcaatggga gagactgcct ttgtcaactc tgtgcacagc      360

cgatgtcgtc cagtccgaaa gaaaccacct tctccagcaa ttgtgccggc tgcggaagag      420

atatcaagaa tgggcaggcg ctgctggcgc tggataagca gtggcacttg gggtgcttta      480

aatgcaagtc ctgcgggaag gtcctcaccg gggagtacat cagcaaggat ggtgctccgt      540

actgtgaaaa ggactaccag ggactctttg gggtgaaatg tgaggcgtgt caccagttta      600

tcacagggaa agtcctggag gcaggtgaca aacattacca ccccagctgt gcacgatgca      660

gcagatgcaa ccagatgttc acagaaggag aggaaatgta tcttcaaggc tccaccgttt      720

ggcatcccga ctgtaagcaa tctacgaaga ccgaggaaaa gctgcggcct accaggacat      780

cctcggaaag tatttattct aggccaggct ccagtattcc tggctcacca ggtcatacta      840

tctatgcaaa agtagacaat gagatcctgg attacaagga tttagcagcc attccgaagg      900

tcaaggcaat ttatgacatt gaacgtccag atcttattac ctatgagcct ttctacactt      960

cgggctatga tgacaaacag gagagacaga gccttggaga gtctccgagg actttgtctc     1020

ctactccatc agcagaaggg taccaggatg ttcgggatcg gatgatccat cggtccacga     1080

gccagggctc catcaactcc cctgtgtaca gccgccacag ctacactcca accacgtccc     1140

gctctcccca gcatttccac agacctgatc aaggaatcaa catttaccga aagccaccca     1200

tctacaaaca gcatgctgcc ttggcagccc agagcaagtc ctcagaagat atcatcaagt     1260

tttccaagtt cccagcagcc caggcaccag accccagcga gacaccaaag attgagacgg     1320

accactggcc tggtcccccc tcatttgctg tcgtaggacc tgacatgaaa cgcagatcta     1380

gtggcagaga ggaagatgat gaggaacttc tgagacgtcg gcagcttcaa gaagagcaat     1440

taatgaagct taactcaggc ctgggacagt tgatcttgaa agaagagatg gagaaagaga     1500

gccgggaaag gtcatctctg ttagccagtc gctacgattc tcccatcaac tcagcttcac     1560

atattccatc atctaaaact gcatctctcc ctggctatgg aagaaatggg cttcaccggc     1620

ctgtttctac cgacttcgct cagtataaca gctatgggga tgtcagcggg ggagtgcgag     1680

attaccagac actcccagat ggccacatgc ctgcaatgag aatggaccga ggagtgtcta     1740

tgcccaacat gttggaacca aagatatttc catatgaaat gctcatggtg accaacagag     1800

ggcgaaacaa aatcctcaga gaggtggaca gaaccaggct ggagcgccac ttagcccctg     1860

aagtgtttcg ggaaatcttt ggaatgtcca tacaggagtt tgacaggtta cctctttgga     1920

gacgcaacga catgaagaaa aaagcaaaac tcttctaagt cccactcgtg aatggcaatt     1980

agagaaagga ctgacagtgg cggtgcccca taggatgtca tattgaggcc caaacttgat     2040

tggagaattt gcaaactacc gtcgctcagc aacaccaaaa agagaaagtc tggttaaaac     2100

accatgagtc aaatgtcggg ccagccaaca gtaacacttg ccaagaagca tggcgtagaa     2160

atttctatgt tccgaaacac agagtagtgt ccacatgtga gcttttcaca ttaccttatg     2220

tatacaacag gagctgcgtt gttttcttct ttttcttttc ctttatctgt tgtccaacaa     2280

cagtgctgac tgtccggata agagctggca agtgccctta ggatgccgca tgggaaaaat     2340

cggttatcat aatttcaaag tataaatata tttattaagt agcgctgcgg ctaagaagga     2400

agagtgaggg gtctgtccat ggggtggcag tgatttcaca cccgcctttc ttgaatggct     2460

tcgtgttact cagccgtgcc ctggcaggaa tggaactcca tcagggaaca gggcagctct     2520

gtttgaatgg ggtgaaaaac agcaaaatta attcttagca agctccttgt tctctactgt     2580

tcaccgggac ctggctggca aatgacttag ctattagtat atttaaaaac tgttcaaaag     2640

caaaagagaa ggaacaggaa tgaaaggaaa ccttccctta actctttctg cttcccatag     2700

caggtctggt tcctgctccc cgcctaggac aggagctgtc tggagctcca cctttgcaaa     2760

gaaaggaaaa acacaaattg cccccagatt ggcccagtgg catgccatta ggtgattttg     2820

cataggggcc atatcattca tggccaaaaa aaaccaaaaa gcaaaaaaca aaaacaagtc     2880

ccatgtccta ctgactctag ttcttccagt cgttatcctc tgctgtctct ctggcatcct     2940

atgaatcaga tcaagcccat gctgttgttg gtttttaagg tttctttcaa taataggcta     3000

aggaaagaca tgtttttctc ttttaaatct ctgcaactcc aaagtagact ccttcgaacg     3060

tatttaattt ggccttttca gctttcttct tgcccagctc tgtcgaattc atgggtgtgt     3120

gtgcacatgt tggtttcact cacccagagt aattttgtga gcatgcatgt gctttttaat     3180

ttctgcttga atgtttgtcc tgctgtgttg cagcttctaa agacattgtc accgagtgtg     3240

tgtgactcaa agatcaagag tgaggctaaa ctgcgacccc aacatcactt ccttcatgga     3300

aaggtgttgg cgctgatgta gctcatggaa ggatcagact gggaaccaca gaggaaggat     3360

gaggtgggat gtggaggtca gagcatctca cgagagtccc tcaggctctg caacactaga     3420

ttcgaatatg agcctagggt ttccccaaca cgtgcgtgca tatgaaacca catcatgatt     3480

cccgacgtga gttagatgag ggagagtttg tgtaactcca cacccaggag ggtaagccac     3540

tttattatca tgctttgggg ctgtgcttaa gaatttaagc tctgttttaa agccgaagaa     3600

gaaaacattt gaatttacct tcatatgcca ctaagaacaa aagctctgaa gttcttcctg     3660

ctggcaccaa atattaggat tacaagctgt ctctctgaca ccagtggtaa aaaagcaagt     3720

agaatagttt ctgagtctgt gttgcagcct ctgacacgtg gctcaccgct gtcatttggg     3780

ggatggaatg aacagtcact gttctatagc atcctcctgt gctcttacct aaggaatcta     3840

aattgtccta gccttccatt gctatgcact gaatgaggac tactctcgtg tgtgtgtgtg     3900

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgg atctactaac atgtttagca     3960

aatggctctg acagggtggc catgagcaga tgagaccagc tcttgcttgg ttggaagcca     4020

cactgcagtt tgcagtttag cctttggtgt ctcagtggct tcttgcttat tccatgcttt     4080

ttctatccca tcctctctct gtgccctcct gcaatggcag ccttggcaca atgcctgggt     4140

gtcctcatcc ttgctttact ctggaaagtg tggggatgga gaggatggtg catttccagt     4200

gcttccttac ctgtcaataa caatggtggc cacctgggtc ccagcacttg gctggtggag     4260

agattttttt cattatggag ctaataaagg gtccctacgt tttacattga ttaatgaatt     4320

atcacccaga catgtgcaga tgaaatgtca atataagaaa aatcaaggta tttgggaaac     4380

atgggcataa tcaggtagtt ttgctaaaat tcctcttcct tggtctacat aaagaagaca     4440

tgggtctgtc atagaatggg gacattagac tgaaaactgg gacaaccccc ttccttattt     4500

tatagagact aggagttaag gggcctgcct aagattgcag tgataaagaa ctgaacccta     4560

aatcagctcc cactaatgaa accctgcttt ccttgtatct tttaaactca gttctgcatc     4620

caacttgaga agaaaaaaag cttctttcca tatcaagtac catatgagtt catttaaact     4680

gcaccttgca gaaatgcatt gccagaaagc accagtagcc tcctatctgc aagcagagta     4740

gtgctctgct ctggggaggg gtcattggaa accataatgc agagtgggcc ccctactcca     4800

tttcccagca aaaggctcca gctggaggga tgggttgtgg ggcaacctgg ttcctgctaa     4860

ctgccagatt gaatgtgtgg gctagaatgc ctgcacattt agttaaactg ggctcagcat     4920

gcttgtcctc aaaatgtcca tcctggtcac agcacacaag atggctattg gtctgctttt     4980

accctaccct gtactataca tgaaaattcc agttattaac acactcaaac tggtggagct     5040

tgttcaccct aggaagggga ttgtatatat ggcaggcttc cctggtgccg atgtaaaggg     5100

ctacatttgg gaacatttga cttccttggg actcttaagt gcataatgat ggcatgaagt     5160

aaaaggggcc tcaatgatga taggaaaatc agttctttta aaatttcttc aagaaaatcc     5220

aggctatcac atagtctttc tgtgtgactt attaggagat aggaagagca ttgggaaact     5280

tgcacagcta gctatgcatc tacattttgg tttggggtta gttatgaaat gttcttaata     5340

tgacgtgttc aataacttca cataaacttc ctgttctcca aaacctcaaa gagatagagt     5400

taatgagttg ttgttttttt ttaaatgggg gtagttttct atctgtcatg ggctctagca     5460

tctactccgc tacccaattc tgtcatctcc aagctgagtt tcctcttctg aggcagaggc     5520

tggagcagtt ctttttcagt tctcatcctc tccatcccaa tccagtatat caatcaactc     5580

taactcggag acgtctagct ggcaatgttt ctaaaacttt cactggattt ctttagacat     5640

tgaagcaaac atttttttct aagaattgct tctcagatga tgatatcaaa tgtatatgct     5700

tttgcaagtt tgaaaagttc aaattaacca cttttgacta ggtaagtctt tctaaaaacc     5760

atttaaagct aactgggtct tagcatcctc ctgtgtatgg aagagacagg tgaccgctcc     5820

aggttgggtg ctcacagaac ccttttcctg actctcatgg aagatggtgg aaggaaaata     5880

gactgtctca tcaaccctcc tgtgtcctct gaagcaatct cagtttttat taaccacctc     5940

ttctgtgttt ctggtagcta tttaacctgt atttaatctg tacttcctat gccagcctca     6000

attttatttg atttttacaa ttattctctt ctaaccaatg aagtgtttgt cagtatgccc     6060

caaagcttgc tcttttgtgc tcccttttga ataactttct atccagaaaa agagattatt     6120

tgggacttga gatttgcagt gataccaact tatagcaatg atgtacttta agggaactac     6180

ccaactatgt tgtgatagaa gaaagagaaa ccttcacttt ggcatttttt tttaatcact     6240

gtttattttt ctgtttgcgg cccaggaagc agtgggaggt ggtggcagat atgctttgca     6300

tatggattgt tatgttttta tttgggcaag tttaatcatg gaaaactcaa aaagaagggg     6360

ggaaatggtc agtttaagcc aaaagaaact ttctaaacaa tgtataggta cacagcaaaa     6420

ttaaacaaat ccaacaattt ctgaagctta gtgtaattga gtggtggttg ttattcaata     6480

aaattattcc caaaagtgtt tctcctaaga gtgcagttcc catgagtcac ttcctgaacc     6540

cattgaccaa aggtggacag agacaatcct gtagaccttg acattcagaa agatgtgagc     6600

tgcttactga tcatatatgc atacgtttct ttacagcaga ggaaaccatt gtccacaaaa     6660

ctgatgttct tttggggttt tatgtacaga cttgtccaat catgtgtgtg gttcctgcga     6720

gttgctgatg actccgcatt gaagctctct gagttctttg attttaagtt gggtttatgg     6780

aattttttca aatgttggaa ggtgtgtggt tcttcctgcc ctccctcccc ttttggaaat     6840

atgaaagcaa atgtttagaa gaattccttt tgaaaagctg tgtcgtgttc cctgtgaaac     6900

tgagcaggtg tgtgttggcg cgctaagtgc cacatgcttg tgtgtagagg aggaggtggc     6960

cctgccggct ccgcgctgct gtgcctgtga tccctacctg ctccccgctc ctgttgccag     7020

cagcactcac tgcactcctt tgtcatatac tctgcatcac tgtcatactc acaacttcgt     7080

gaataaagtt gtgtgcttta ttcgt                                           7105


<210> 2294
<211> 2299
<212> DNA
<213> Homo sapiens

<400> 2294
atgacccagc agtggaggga agtgaatgag gacagagaag cagtggccca ggccaggagc       60

tggcaatcgc tgaatctggg cgatagggac atgggggtca gtttcatcga aactgccttg      120

gcgctctctg cagcccgggc ccgccgccct ctccttacct cccatccccc atcccgcccc      180

ttccagcctc ccaagcacac gccctcgccc ccacccgccc cccgcgttaa ttcgcgccat      240

ccagggcgct ctgtgagtct gtcattaccc agcgcgagtc aggcccctcc tgtgcccctc      300

gccagccccg aggggcgccc gcacacagtc ggcgccccac acgcaagtac ctggaagaga      360

acaagaggac gccagcgggc gcggccgcca aagatcgtta aggaggctga ggtgccgcag      420

gctgcgctgg gcgtcccagc ccaggggaca ggggacaatg gccacacgcc tgtggaggag      480

gaggtcgggg gcatcccagt accagcaccg gggctcctgc aggtcacgga gaggaggcag      540

cctctgagca gcgtctcctc tctggaggtc cacttcgacc tcctggacct cactgagctc      600

accgacatgt cggaccagga gctggccgag gtctttgctg actcggacga cgagaacctc      660

aacaccgagt ccccagcagg tctgcacccg ctgccccggg ccggctacct gcgctcccct      720

tcctggacga ggacaagggc tgagcagagc cacgagaagc agcccctagg cgaccccgag      780

cggcaggcca cagtcctgga cacgtttctc actgtggaga ggccccagga ggactagacc      840

atctccacct gccccagctc ctgcagggat ggggtccgaa cacgatggca gatctgggca      900

gtgctgaccc agcagacaca cttcacccgc ccacgaggct ccagccgtca cctcctgaca      960

cacaccctgg gggcagctct ctgccagccc cgagaccggc cttgtctgct gggcacgggt     1020

cttcgcctca cttggagacc agccggcttt cctgggggac acacggggcc cccggatgcc     1080

tctgggagcc ccagcacaag cacagcccag tggccttacg tccagctcgt tcctgggccc     1140

cgagtcagga agacagcgtc acggagtcac tgccaggaac gtgctgagga atggagtggc     1200

ccacggcggc cttggggtga aggggaccca ggcctgtgac agccactcca ggaactcctg     1260

ggggtgctcc aacctccgcg ttttcctgtg ctgccaagct cagaagccag aggcgggttt     1320

ggtagtggct aatgggacaa tgtgctgtcc agcaaagcac acatggagaa gcggccccaa     1380

aattcccacc ttgatttcca tcctgcccct tcttctactc cacggaggcg ctgtctcact     1440

agggtcccct ccccaaggct cagctctaag acctgcacct gcttctcttg gcccctgcgt     1500

gacagacaag tccattccct ccttagctca gaacaccaaa tatcaccaga ctgcctaaga     1560

gacttgatga cacctcccgg aatgctctcg gggtggggtt cacctctcct tgtcctgcac     1620

ccactgctag gccacattct cgtttctgct cacatcccat tgcccggcta caaggcctgc     1680

ccacggccct taaacttgct gggcaggttt ggagcccatg ggaccccgtg ggtctctgtc     1740

caggagcagc agaggaggct gacaggccct gctccctctg ctctgggggt gtctgggagc     1800

cccagctcac accctcccaa tgcttatatg ctgaagctca cagaatgggc ttcttgcctg     1860

acagcaagtc aaagaatgag tttaatatca aagtgtaagc ttactttcca tccccaagcc     1920

agcctgcccc ctgccccatt tcccatgagc acacttctgg ggaaggaaaa caggctcctg     1980

gccttcactc tcagcagagc tttggagatg ccccaggcat gccctgagct ccttctgtgt     2040

acctgctccc acttctgagc cacccgctgc ccctccgcac tgctggcaaa cccagttcct     2100

gcctcagcca ggtctccttc cctggtttcc agtcacacag agcccagcag ctttctcttt     2160

cagtcccata agggcagcct tgtgtccctg gccacacttc cacccgccag ggtcttcctc     2220

cccatctttc catccttcct gctgagcttc cacagagctc gtttgcaaac agggggatta     2280

aagcatcact gcgcattcg                                                  2299


<210> 2295
<211> 927
<212> DNA
<213> Homo sapiens

<400> 2295
gcggcggcca tctctgggcg gcggcggcgg gcggtgtttg cgcggtcggt gagacccgcg       60

cgggtgagac gctggccctc cttacagcct agaaaaaatg acagatctcg tagctgtttg      120

ggatgttgct ttaagtgacg gagtccacaa gatcgaattt gaacatggga ctacatcagg      180

caaacgagta gtatatgtag atggaaagga agagataaga aaagagtgga tgttcaaatt      240

agtgggcaaa gaaacattct atgttggagc tgcaaagaca aaagcgacca taaatataga      300

cgctatcagt ggttttgctt atgaatatac tctggaaatt aatgggaaaa gtctcaagaa      360

gtatatggag gacagatcaa aaaccaccaa tacttgggta ttacacatgg atggtgagaa      420

ctttagaatt gttttggaaa aagatgctat ggacgtatgg tgcaatggta aaaaattgga      480

gacagcgggt gagtttgtag atgatgggac tgaaactcac ttcagtatcg ggaaccatga      540

ctgttacata aaggctgtca gtagtgggaa gcggaaagaa gggattattc atactctcat      600

tgtggataat agagaaatcc cagagattgc aagttaatga attttcatct taagaagtaa      660

agatcaggac tttttaatta ctgtggtaat taaatgtgtt cagtatgtac ttatcagtac      720

atttagtctg caatgtttta attttttaaa aagttacatg aaactaacat tccaagggtc      780

aggaaaaaaa ccaattatgt atagtcataa aaattacaat ttatgatgca aataatgtaa      840

aatgttttaa agacaaatgg caaataagat atggaccaaa gtcactaatg ttttacaaca      900

gtaaccttta ctataataaa tactttt                                          927


<210> 2296
<211> 946
<212> DNA
<213> Homo sapiens

<400> 2296
ggccacgcgg cctacgcagc cgagtcggaa ccaaccggtt gtttggtgaa acctacccca       60

gagcctcccg cggcccacag agcacagccc tccttacagc ctagaaaaaa tgacagatct      120

cgtagctgtt tgggatgttg ctttaagtga cggagtccac aagatcgaat ttgaacatgg      180

gactacatca ggcaaacgag tagtatatgt agatggaaag gaagagataa gaaaagagtg      240

gatgttcaaa ttagtgggca aagaaacatt ctatgttgga gctgcaaaga caaaagcgac      300

cataaatata gacgctatca gtggttttgc ttatgaatat actctggaaa ttaatgggaa      360

aagtctcaag aagtatatgg aggacagatc aaaaaccacc aatacttggg tattacacat      420

ggatggtgag aactttagaa ttgttttgga aaaagatgct atggacgtat ggtgcaatgg      480

taaaaaattg gagacagcgg gtgagtttgt agatgatggg actgaaactc acttcagtat      540

cgggaaccat gactgttaca taaaggctgt cagtagtggg aagcggaaag aagggattat      600

tcatactctc attgtggata atagagaaat cccagagatt gcaagttaat gaattttcat      660

cttaagaagt aaagatcagg actttttaat tactgtggta attaaatgtg ttcagtatgt      720

acttatcagt acatttagtc tgcaatgttt taatttttta aaaagttaca tgaaactaac      780

attccaaggg tcaggaaaaa aaccaattat gtatagtcat aaaaattaca atttatgatg      840

caaataatgt aaaatgtttt aaagacaaat ggcaaataag atatggacca aagtcactaa      900

tgttttacaa cagtaacctt tactataata aatactttta aaaaaa                     946


<210> 2297
<211> 1412
<212> DNA
<213> Homo sapiens

<400> 2297
agttgcaact tgtctttgag tgcagggaca ggagaagtgt gggctacccg gccactgccc       60

tggagctgtg gtgactgctg cgtttttctc ccatgcactt gcacgtccag gactcctggg      120

agaacttggg ccacactcct tccttgccct cttgagctca ttcgtcaccc tgttgggtga      180

gcacagccct agctcaggcc actgggcaag ccacaccatc caaagaggag gtcctctgcc      240

ccaggacccc cacaccaccc cagctccctg tttcgctgag gcctggagcc cccatggcct      300

cactgagccg agccctacgt gtggctgctg cccaccctcg ccagagccct acccggggca      360

tggggccatg caacctgtcc agcgcagctg gccccacagc cgagaagagt gtgccatatc      420

agcggaccct gaaggaggga cagggcacct cggtggtggc ccaaggccca agccggcccc      480

tgcccagcac ggccaacgtg gtggtcattg gtggaggcag cttgggctgc cagaccctgt      540

accacctggc caagctgggc atgagtgggg cggtgctgct ggagcgggag cggctgacct      600

ccgggaccac ctggcacacg gcaggcctgc tgtggcagct gcggcccagt gacgtggagg      660

tggagcttct ggcccacact cggcgggtgg tgagccggga gctggaggag gagacgggac      720

tacacacggg ctggatccag aatgggggcc tcttcatcgc gtccaaccgg cagcgcctgg      780

acgagtacaa gaggctcatg tcgctgggca aggcgtatgg tgtggaatcc catgtgctga      840

gcccggcaga gaccaagact ctgtacccgc tgatgaatgt ggacgacctc tacgggaccc      900

tgtatgtgcc gcacgacggt accatggacc ccgctggcac ctgtaccacc ctcgccaggg      960

cagcttctgc ccgaggagca caggtcattg agaactgccc agtgaccggc attcgtgtgt     1020

ggacggatga ttttggggtg cggcgggtcg cgggtgtgga gactcagcat ggttccatcc     1080

agacaccctg cgtggtcaac tgtgcaggag tgtgggcaag tgctgtgggc cggatggctg     1140

gagtcaaggt cccgctggtg gccatgcacc atgcctatgt cgtcaccgag cgcatcgagg     1200

ggattcagaa catgcccaat gtccgtgatc atgatgcctc tgtctacctc cgcctccaag     1260

gggatgcctt gtctgtgggt ggctatgagg ccaaccccat cttttgggag gaggcagtca     1320

aatacagacc cagggcagct ggagggcttt gcctcaaaac atccacagag aaggtctgcg     1380

cagtgtggag tgatgacctc agaagggcat ga                                   1412


<210> 2298
<211> 3100
<212> DNA
<213> Homo sapiens

<400> 2298
cgcggctgca tggacgcggg tccggcgcgc gggaggcgat gacggccccg ccatggcccg       60

ggcgggcagc tgcggcggcg ccgcggcggg cgcagggcgg ccggagccct gggagctgtc      120

cctggaggag gtgctgaagg cctacgagca gccgctcaac gaggagcagg cgtgggccgt      180

gtgcttccag ggctgccgcg ggctgcgggg ctcgccgggc cggcgcctgc gggataccgg      240

ggacctcctg ctgcgcgggg acggctcggt cggggcgcgg gagcccgagg ccgcggaacc      300

tgcaaccatg gtcgtgccac tagccagctc ggaagcccag accgtgcagt ccctcggctt      360

cgccatctac cgcgcgctgg actgggggct ggacgagagc gaggagcgcg aactcagccc      420

tcagctggag cggctcatcg acctcatggc caacaacgac agcgaggaca gcggctgcgg      480

tgccgccgat gagggctacg ggggtcccga ggaggaggag gaggccgagg gcgtcccccg      540

cagcgtgcgc acctttgccc aggccatgcg gctgtgcgcg gcgcggctga ccgacccccg      600

gggcgcacag gcgcattacc aggccgtgtg ccgcgcgctc ttcgtggaga cgctggagct      660

gcgggccttc ctggccaggg tccgggaggc caaggagatg ctgcagaagc ttcgggagga      720

cgagccgcat ctggagacgc ctcgggcaga gctggacagc ctgggtcaca cagactgggc      780

ccgactgtgg gttcagctca tgcgggagct ccgccgcgga gtgaagctga agaaggtgca      840

agagcaggag ttcaaccccc tccccaccga gttccagctc acgcccttcg agatgctgat      900

gcaggacatc cgggcccgga actacaagct gcgcaaggtc atggtggatg gggacatccc      960

gccccgggtg aagaaggacg ctcacgagct catcctggac tttatccgct cacggcctcc     1020

actgaagcag gtctctgaga ggcggctgcg cccgttgcca ccaaagcaaa ggtccctgca     1080

tgagaagatc ctggaggaga tcaagcagga gcggaggctg cgcccggtgc ggggcgaggg     1140

ctgggctgcc cgcgggtttg gctctctgcc ctgcatcctc aacgcctgct ccggagatgc     1200

caagtccacc tcctgcatca acctgtcagt cacagatgct gggggcagcg cccagcgccc     1260

gcggccccgc gtgctgctca aggcgcctac cttggctgaa atggaagaga tgaatacatc     1320

tgaggaagaa gagtctccgt gtggggaggt gacgctgaaa cgggaccgct ccttctcaga     1380

gcatgacctg gcccagctcc gaagtgaggt ggcctctggc ctgcagtcgg ccacccaccc     1440

cccaggaggg acggagccac cacggccccg agctggcagt gcgcatgtgt ggaggcccgg     1500

ctcccgagac cagggtacct gtcccgcgag tgtctctgac cccagccacc ccctactcag     1560

caaccggggc tcctcggggg acagacccga ggcctccatg acccccgatg ccaaacacct     1620

gtggctggag ttcagccacc ccgtggagag cctggcgctg actgtggaag aggtgatgga     1680

cgtgcgccgt gtgctggtga aggccgagat ggaaaagttt ttgcagaaca aggagctctt     1740

cagcagtctg aagaagggga agatttgctg ctgctgccgg gccaagttcc cgctgttctc     1800

gtggccgccc agctgtctct tctgcaagag gtctctgcaa gggccacagt ggcagagcgt     1860

ggaggaggcg ttcccccaca tctactccca cggctgtgtc ctgaaggatg tctgcagtga     1920

gtgcaccagc tttgtggcag acgtggtgcg ttccagccgc aagagcgtgg acgtcctcaa     1980

cactacgcca cgacgcagtc gccagaccca atccctctac atccctaaca ccaggactct     2040

tgacttcaag tgacagcccc aggtggccag gcctccagga ggcaccaggc aggccctgta     2100

tcaggctagg acgctctgag ctgtgcatgt acatatatac atatatagat acatttataa     2160

tatatacaca cagtctatat atttatatac actgtttcct ggccccagag ctcatttggg     2220

ttcaggcgca cttcaaaacc ctccctgggg gaggctgttt cttctcagga ttccttgcca     2280

gggaggaagg ggagggaaca gggtgggttt tctcactgaa gagagaaagc agaaggttct     2340

agatcctggc acagactgca tcccatgttc ccatgctctt ctccgtcccc aggaatgcga     2400

acggcagttt cccttcccca gtggacgtct aggtggggac agggtatctt ggctcccagc     2460

tggaccagag tgccctgctt gcctctgctc tccctttgtg gggactcagg cagcagaggc     2520

atctgggaag tctctgagta ggcagggtcc tcctgggagg cacccccacc tgtttgaaag     2580

gtctggccag gcgtggtggt tcaggcctgt aattccagca ctttgggagg ccgaggaggg     2640

aggatcacct gaggtcagga gtttgagacc agcctggcca acatgatgaa atgttgtctc     2700

tactgaaaat gcaaaaatta gccaggtata gtggcaggaa cctgtaatcc cagctacagg     2760

ggaggctgag gcaggagaat cgcttgaacc cgggaggtgt aggttgcagt gagccgagat     2820

tgcaccactg cactccagcc tgggcgacag agcgagactc tgtctcgaaa aaaaaaaagg     2880

tccgtgccaa gctgctccct gcccttgccc tttccctttc cctggggtcc aaaccacatg     2940

tgtcctgcct ctcctggccc taccacattc tggtgctgtc ctcactcgcc cctggcccag     3000

aggctcctga agatgctggg cggtcctggc acagggagga gcagctctgt aaatctgtgc     3060

acatggccac tcttggccta ataaaggagg tctcacagtc                           3100


<210> 2299
<211> 1482
<212> DNA
<213> Homo sapiens

<400> 2299
cagagtttgg gcgccaggcg agacggcagg gcttaaagtt ccgggaatca aagatcaact       60

cccactgagg acaaatggac ctgtaattcc gggtgtgacg agagaacgag atttaccttc      120

ctgaattaaa aaacaggtca ttaagcttgg gccctgactc ttctttgtga gaaggtacag      180

agatggaaac cttacaatcc gagactaaaa cgagggtcct tccctcatgg ctgacagccc      240

aggtggctac aaagaatgtg gcaccaatga aggcccccaa gaggatgaga atggcagcag      300

tgccagtggc agcagcaaga ctccctgcga caaggactgt gtactgcatg aatgaggctg      360

agatagttga tgttgctctg ggaatcctga ttgagagccg caaacaggaa aaggcctgcg      420

agcagccggc cctggcgggg gctgataacc cagagcactc ccctccctgc tccgtgtcgc      480

ctcacacaag ttctgggagc agcagtgagg aagaggacag tgggaaacag gcactggctc      540

caggcctcag cccttcccag aggccggggg gttccagctc tgcctgtagc aggagccctg      600

aggaggagga ggaagaggat gtgctgaaat acgtccggga gatctttttc agctagggca      660

taaactgtgc actgaactgt ctgccgagag cagctggagg acagctgagc ttccactggt      720

gctgctgggc cgcccgcctg tgggaatggg gctctctgtg ctcctacctt tgtgccttct      780

tgggcctggc agattcacct caggccagaa gcccctggac actccgggcc ttggggctgc      840

cgttctgagt gtgcggaagg caggactcaa aatgagatcc catttgactc cctctgtatg      900

tactgtgccc tctcctggct cttgaggctc tggagtccca attgtctgtg ttagtcagtg      960

accaggttcc agggaaaatg atgtcatgtg gtggtccaac ttactggaac caaagagaca     1020

gtactttgca aagaaaagga tcactgccag gtgcactgga attgctacag tttagtccgc     1080

atgatctctc ctgaaggagg aagcctgttt caaaaatagt ttccatcatg agtctatcaa     1140

tgagctccca cctctccagc cagcctagaa agcaaacgag ctgcccacag ttctctgccc     1200

tgtctgggag gttgaggcca cagtgtatag actggtaagc cagacaggcc tcctcccgca     1260

agctgctacc ttgctttcac ctgtaccttg gtccccgggc agctagctat aaagcaagag     1320

ggacaggagc ccagaagaga cactgaggac aagagatcac accagagtac atgtctctgc     1380

ctctgttttc agtgtggctt tggacaggaa tatatgaata aatcactgcc atacaggttt     1440

tccaatacac aagtgctaga aaatacacac aattccccaa tg                        1482


<210> 2300
<211> 1021
<212> DNA
<213> Homo sapiens

<400> 2300
aaccacgtgg gtcccgggcg cgtttcgggt gctggcggct gcagccggag ttcaaaccta       60

agcagctgga aggaaccatg gccaactgtg agcgtacctt cattgcgatc aaaccagatg      120

gggtccagcg gggtcttgtg ggagagatta tcaagcgttt tgagcagaaa ggattccgcc      180

ttgttggtct gaaattcatg caagcttccg aagatcttct caaggaacac tacgttgacc      240

tgaaggaccg tccattcttt gccggcctgg tgaaatacat gcactcaggg ccggtagttg      300

ccatggtctg ggaggggctg aatgtggtga agacgggccg agtcatgctc ggggagacca      360

accctgcaga ctccaagcct gggaccatcc gtggagactt ctgcatacaa gttggcagga      420

ccatggccaa cctggagcgc accttcatcg ccatcaagcc ggacggcgtg cagcgcggcc      480

tggtgggcga gatcatcaag cgcttcgagc agaagggatt ccgcctcgtg gccatgaagt      540

tcctccgggc ctctgaagaa cacctgaagc agcactacat tgacctgaaa gaccgaccat      600

tcttccctgg gctggtgaag tacatgaact cagggccggt tgtggccatg gtctgggagg      660

ggctgaacgt ggtgaagaca ggccgagtga tgcttgggga gaccaatcca gcagattcaa      720

agccaggcac cattcgtggg gacttctgca ttcaggttgg caggaacatc attcatggca      780

gtgattcagt aaaaagtgct gaaaaagaaa tcagcctatg gtttaagcct gaagaactgg      840

ttgactacaa gtcttgtgct catgactggg tctatgaata agaggtggac acaacagcag      900

tctccttcag cacggcgtgg tgtgtccctg gacacagctc ttcattccat tgacttagag      960

gcaacaggat tgatcattct tttatagagc atatttgcca ataaagcttt tggaagccgg     1020

a                                                                     1021


<210> 2301
<211> 1193
<212> DNA
<213> Homo sapiens

<400> 2301
ggagttcaaa cctaagcagc tggaagggcc ctgtggctag gtaccataga gtctctacac       60

aggactaagt cagcctggtg tgcaggggag gcagacacac aaacagaaaa ttggactaca      120

gtgctaagat gctgtaagaa gaggttaact aaaggacagg aagatggggc caagagatgg      180

tgctactgtc tactttaggg atcgtctttc aaggcgaggg gcctcctatc tcaagctgtg      240

atacaggaac catggccaac tgtgagcgta ccttcattgc gatcaaacca gatggggtcc      300

agcggggtct tgtgggagag attatcaagc gttttgagca gaaaggattc cgccttgttg      360

gtctgaaatt catgcaagct tccgaagatc ttctcaagga acactacgtt gacctgaagg      420

accgtccatt ctttgccggc ctggtgaaat acatgcactc agggccggta gttgccatgg      480

tctgggaggg gctgaatgtg gtgaagacgg gccgagtcat gctcggggag accaaccctg      540

cagactccaa gcctgggacc atccgtggag acttctgcat acaagttggc aggaccatgg      600

ccaacctgga gcgcaccttc atcgccatca agccggacgg cgtgcagcgc ggcctggtgg      660

gcgagatcat caagcgcttc gagcagaagg gattccgcct cgtggccatg aagttcctcc      720

gggcctctga agaacacctg aagcagcact acattgacct gaaagaccga ccattcttcc      780

ctgggctggt gaagtacatg aactcagggc cggttgtggc catggtctgg gaggggctga      840

acgtggtgaa gacaggccga gtgatgcttg gggagaccaa tccagcagat tcaaagccag      900

gcaccattcg tggggacttc tgcattcagg ttggcaggaa catcattcat ggcagtgatt      960

cagtaaaaag tgctgaaaaa gaaatcagcc tatggtttaa gcctgaagaa ctggttgact     1020

acaagtcttg tgctcatgac tgggtctatg aataagaggt ggacacaaca gcagtctcct     1080

tcagcacggc gtggtgtgtc cctggacaca gctcttcatt ccattgactt agaggcaaca     1140

ggattgatca ttcttttata gagcatattt gccaataaag cttttggaag ccg            1193


<210> 2302
<211> 1084
<212> DNA
<213> Homo sapiens

<400> 2302
cctttctgag cagctgtgtt tgaagaaagc tagtgggaaa agttccagga ttacatgtca       60

ggaaactaca agaggtagaa acatttgttg atttaccagt gtttttaact tcctgctggg      120

ctgaaaactg cttgtttcgt ggaaaagcaa aacttgacag caaacatcta aaatgaagag      180

ctcccaaact tttgaggaac aaacggaatg cattgtgaac actctactca tggacttctt      240

gagcccaaca ttgcaggttg ccagccggaa cctatgctgt gtagatgaag tagattcagg      300

agagccttgt tcttttgatg tggctatcat tgctggtcgc cttcggatgt tgggtgacca      360

gttcaacgga gaattggaag cttctgccaa aaacgtcatt gcagaaacca ttaagggaca      420

gacaggagct atactccagg acactgtgga atctctcagc aagacctggt gtgctcagga      480

ttccagctta gcttatgaga gagcttttct ggcagtgtca gtgaaacttc ttgagtacat      540

ggctcacatt gctcctgaag tagtgggaca ggtggctatc cccatgacgg gtatgatcaa      600

tgggaaccaa gccatccggg agttcatcca gggccaggga ggttgggaaa atctggagag      660

ctgaagagtt ggagctattc acgagactga acatcacttc cttgttgact gattgggtga      720

ttgattcctg ggaattcaaa caaacaaata aaaaagcact tttttcattt tatcagaact      780

gaacttagct gaataagtta ttttttactg attgttaaag ttgggagcag ctgccagagg      840

cctgcagagt tggtttttgt tttgttttgt tttgtcaact taatgcaaac cacagagatt      900

ttctactttc tgttttcaca tgagttttaa tgaggttctg ttgaagcaaa gacccctaga      960

cacaaagtaa tgacttgtta gtagtggaat tataagcaac agggcaggcc tttgctggag     1020

gtattttgag agaaagggag aacaatggaa actatttctt cagatgtagc cctgtctttt     1080

ggta                                                                  1084


<210> 2303
<211> 2422
<212> DNA
<213> Homo sapiens

<400> 2303
gtgagggaac gcgctttcga ggcggaggtt aggagcgggg agcgcgcccg ggtccagcgt       60

cctgcttctc cgcttcccgc gctgagctct tcgcctgtcg ctgaggcgtc ggtgccagct      120

gcgtgaagga tggagagggc ggggcgcgaa tcctgagcca gagactgagt gcttgggggt      180

gggccgagca cttgggggcc gctcttcggg gcccgggtgg tctggaacaa tgttgcttgg      240

ctgggcggct gcgggatagg gcggaagggg acaggcttga ggcttggata ggcgtgagga      300

ggcgcatacg accgcacaac ccgaggtttg taactgtatt cggaagacgc cgggtccggc      360

tgggactgcc agaggaacct ggctttgcag gactacggag gagtaacgtc gagtgaattg      420

gaagagggcc cagggccgca caagcagcgt caccctttac accagaaagc tggcgggcac      480

tatggggaaa aaacaaaaca agaagaaagt ggaggaggtg ctagaagagg aggaagagga      540

atatgtggtg gaaaaagttc tcgaccgtcg agtggtaaag ggcaaagtgg agtacctcct      600

aaagtggaag ggattctcag atgaggacaa cacatgggag ccagaagaga acctggattg      660

ccccgacctc attgctgagt ttctgcagtc acagaaaaca gcacatgaga cagataaatc      720

agagggaggc aagcgcaaag ctgattctga ttctgaagat aagggagagg agagcaaacc      780

aaagaagaag aaagaagagt cagaaaagcc acgaggcttt gctcgaggtt tggagccgga      840

gcggattatt ggagctacag actccagtgg agagctcatg ttcctgatga aatggaaaaa      900

ctctgatgag gctgacctgg tccctgccaa ggaagccaat gtcaagtgcc cacaggttgt      960

catatccttc tatgaggaaa ggctgacgtg gcattcctac ccctcggagg atgatgacaa     1020

aaaagatgac aagaactaac gctcctgagt accagcccct gtcacatctg actgtgggtt     1080

tcaagtggga agggaaggag ttctacttgt cttgacacca tagaggtggc ttgagaagat     1140

gtcctttgaa gagccagtat agtttctgtg ccctgcagca gcccaagtgc tttaaagccg     1200

tttcaagctg tatagtttgc acacccatcc cagtggaggg gaaaggggat aagtgtttca     1260

aggcaacctt ttctgcactt tgctgcgaaa agcaaagggc cttctatgaa ggacaaaact     1320

tgcagaattg ggtgtgtggg agagcaaaaa aatactgtag atcttcaaag agcatctcca     1380

caacccacag ccttcttccc aatagtgtta actctgcatt tttacagcgt agcatgtgtg     1440

tagtttttgg ctattactgg tgtattattt gggggaggga gggatgggga ggggagaaag     1500

ggagatgggt agcatcattt tgattaacat ttggggcctg ataggggaaa tggtgaagca     1560

atggaaaaga acagacaact aatgatttgc ttctatgtcc agaatatttt acctttaaaa     1620

aaatgtcatt ggcaccataa ataaggactg tgagagactg tttaaaagct gtgaaagtct     1680

gaaacctata agccaaggtg ttccctgcct aaacttattg ctgttcccac aaaggactaa     1740

gcctgttcat aagttaccaa agttgccatt ttggagatgg aaattgacga ggagggaagg     1800

tcttttattg gagagtatac agtacaagca gatcattctg ccttagaggt gctaattccc     1860

gaaattagaa gaccctttct tttccagtaa cgaagttata aatatcagct tgttcatcca     1920

agccactggc tgaggtgtta ggaagaggaa gagggtggta gaggaggtaa gacagtaggg     1980

aaagacaagg gcccatgctc ttagtgggga aaactcttgg agccgtttac tttgagcttt     2040

gaacactgaa accattgttg gcagggttca gtcactgaca gcacaagttt cactgaattg     2100

atccaagagt ttagtgattt caaaagcctt ggtctcagga gaagattaaa ctttcatatt     2160

gggcagtggt tcactttaaa acacacacat acacacacaa aacaattttt taagaaatcc     2220

taataagtaa catacccaaa atgctctgtc ttgagtcatg agaaccatca gttcttgata     2280

ttgtctagac ttgcatctag agctacgttg taaaattctt ttaggcatgt gttagatttc     2340

tgtgtaaact ttgtttaaat gtaaacttca tactacattg tcagtttttg tcttaataaa     2400

actatagatt tataatccct ga                                              2422


<210> 2304
<211> 2279
<212> DNA
<213> Homo sapiens

<400> 2304
acaagggacc ttatttaggt tgcgcaggcg cccgctggcc atttcgtctt agccacgcag       60

aagtcgcgtg tctaggtgag tcgcggtggg tcctcgcttg cagttcagcg accacgtttg      120

tttcgacgcc ggaccgcgta agagacgatg atgttgggca cggaaggtgg agagggattc      180

gtggtgaagg tccggggctt gccctggtct tgctcggccg atgaagtgca gaggtttttt      240

tctgactgca aaattcaaaa tggggctcaa ggtattcgtt tcatctacac cagagaaggc      300

agaccaagtg gcgaggcttt tgttgaactt gaatcagaag atgaagtcaa attggccctg      360

aaaaaagaca gagaaactat gggacacaga tatgttgaag tattcaagtc aaacaacgtt      420

gaaatggatt gggtgttgaa gcatactggt ccaaatagtc ctgacacggc caatgatggc      480

tttgtacggc ttagaggact tccctttgga tgtagcaagg aagaaattgt tcagttcttc      540

tcagggttgg aaatcgtgcc aaatgggata acattgccgg tggacttcca ggggaggagt      600

acgggggagg ccttcgtgca gtttgcttca caggaaatag ctgaaaaggc tctaaagaaa      660

cacaaggaaa gaatagggca caggtatatt gaaatcttta agagcagtag agctgaagtt      720

agaactcatt atgatccacc acgaaagctt atggccatgc agcggccagg tccttatgac      780

agacctgggg ctggtagagg gtataacagc attggcagag gagctggctt tgagaggatg      840

aggcgtggtg cttatggtgg aggctatgga ggctatgatg attacaatgg ctataatgat      900

ggctatggat ttgggtcaga tagatttgga agagacctca attactgttt ttcaggaatg      960

tctgatcaca gatacgggga tggtggctct actttccaga gcacaacagg acactgtgta     1020

cacatgcggg gattacctta cagagctact gagaatgaca tttataattt tttttcaccg     1080

ctcaaccctg tgagagtaca cattgaaatt ggtcctgatg gcagagtaac tggtgaagca     1140

gatgtcgagt tcgcaactca tgaagatgct gtggcagcta tgtcaaaaga caaagcaaat     1200

atgcaacaca gatatgtaga actcttcttg aattctacag caggagcaag cggtggtgct     1260

tacgaacaca gatatgtaga actcttcttg aattctacag caggagcaag cggtggtgct     1320

tatggtagcc aaatgatggg aggcatgggc ttgtcaaacc agtccagcta cgggggccca     1380

gccagccagc agctgagtgg gggttacgga ggcggctacg gtggccagag cagcatgagt     1440

ggatacgacc aagttttaca ggaaaactcc agtgattttc aatcaaacat tgcataggta     1500

accaaggagc agtgaacagc agctactaca gtagtggaag ccgtgcatct atgggcgtga     1560

acggaatggg agggttgtct agcatgtcca gtatgagtgg tggatgggga atgtaattga     1620

tcgatcctga tcactgactc ttggtcaacc tttttttttt tttttttttt ttctttaaga     1680

aaacttcagt ttaacagttt ctgcaataca agcttgtgat ttatgcttac tctaagtgga     1740

aatcaggatt gttatgaaga cttaaggccc agtatttttg aatacaatac tcatctagga     1800

tgtaacagtg aagctgagta aactataact gttaaactta agttccagct tttctcaagt     1860

tagttatagg atgtacttaa gcagtaagcg tatttaggta aaagcagttg aattatgtta     1920

aatgttgccc tttgccacgt taaattgaac actgttttgg atgcatgttg aaagacatgc     1980

ttttattttt ttgtaaaaca atataggagc tgtgtctact attaaaagtg aaacattttg     2040

gcatgtttgt taattctagt ttcatttaat aacctgtaag gcacgtaagt ttaagctttt     2100

ttttttttta agttaatggg aaaaatttga gacgcaatac caatacttag gattttggtc     2160

ttggtgtttg tatgaaattc tgaggccttg atttaaatct ttcattgtat tgtgatttcc     2220

ttttaggtat attgcgctaa gtgaaacttg tcaaataaat cctcctttta aaaactgca      2279


<210> 2305
<211> 4598
<212> DNA
<213> Homo sapiens

<400> 2305
cccaggccgg ctctggcctc ctgacccaga cagcgcaggg cgcgagggat cgcgcggccg       60

agcccgggtc gcgccgctcc cagcatcggg gccgctagcc aagagttcga ggccttcccg      120

atccggatgt gatgaaaaag agcaacagag ggagaagtgt ttcaggattg taggagtgga      180

agaggggaaa gagaggcaga gagggggaag gccccctcgc aggggagccg gctggagtga      240

gctggctgga aagagggggc ggagtgcgcg gagtcagagc cgccaccgct gccgcagttg      300

ccgccactgc ggcgtctggg ctgagccgga gggaggcggg aggacgcgca ggggcggccg      360

ccgccgtcgt caggccaccg gggcgaaaat gcggccgctg ccggaggctc gctaactttc      420

cggggcggaa gaggaggagg aggaggagga aggggcttgg agcgactacg gggggatgcg      480

gagaagcagt cagttccctg cacccagcac ctcacagccc ttcctccgtg cgccctgccg      540

ggcggcgagc taggcggcag cggcgcggcg cgggctcggc ggagcggccc atgtccggcg      600

cgggcgaagc cctcgctccc gggcccgtgg ggccgcagcg cgtggccgag gcgggcggcg      660

gccagctggg ctccacagcc cagggaaaat gtgataaaga caatactgag aaagatataa      720

ctcaagctac caatagccac ttcacacatg gagagatgca agaccagtcc atttggggaa      780

atccttcgga tggtgaactc attagaaccc aacctcagcg cttgcctcag cttcagactt      840

cagcccaggt gccaagtggt gaggaaatag gcaagataaa gaacggccac acaggtctga      900

gcaatggaaa tggaattcac cacggggcca aacacggatc cgcagataat cgcaaacttt      960

cagcacctgt ttctcaaaaa atgcatagaa aaattcagtc cagcttgtct gtaaacagcg     1020

atatcagtaa gaagagcaaa gtaaatgctg tcttttccca aaagacaggc tcttcacctg     1080

aagattgttg tgtccactgt atcctggctt gcttgttctg cgaattcctg accctttgca     1140

acattgtcct gggacaagcg tcatgtggca tctgcacctc agaagcctgc tgctgttgct     1200

gtggtgacga gatgggggat gattgtaact gcccttgtga tatggactgt ggcatcatgg     1260

atgcctgttg tgaatcatca gactgcttgg aaatctgtat ggaatgctgt ggaatttgtt     1320

ttccttcata aatatttatc ttttgtttgt gttaaaactg gagagtgttt aaaaatttcc     1380

ttttgggggg aagaaaagca cattgtaaga ttctcatgaa acaacatgga atttgcactg     1440

ttaactcatt attgtaagta atctctgaaa gcctttttac tttaaccaaa tctacatggt     1500

ttaatatgtg aaattttaac tactttaact agttttataa atttcttaat atgttacaat     1560

aacttaggga cattttgaca ccccccttcc caaatgttaa atgccttctc ctttttaccg     1620

atatttctgt ttcttttaac cgttctcagg agcactttgc tccaaatata ttatttttca     1680

gtgtgtattt aaacgaggca gtttattttg atatgtatct attcatgatt gaaaggaagc     1740

agtcttggcc aggcacggtg gcttacacct gtaaccctgg cattttggga ggccaaggtg     1800

ggcagattgc ctgagctcag gagttcgaga ccagccaggg caacatggtg aaaccccatc     1860

tctactaaaa tacaaaaagt tagctgggct tggcggtgtg cgcctgtagt cccagctact     1920

caggaggctg aggcaggaga attgcttgaa cccgagaggc ggaagttgca gtgagccgag     1980

attgtgccac tgaactccaa cctgcactcc agcctgggca acagagcgag actccatctc     2040

taaataaata aataaataaa taaataaata aataaataaa taaacaaacc agtctttatt     2100

ttaaaagaaa ctttaggaaa caaacccaca taatagttgg gaaccagtgt tgatctctct     2160

cccttacctt ctccacttgt tcaacagact ctgaatgccg actgtgtgga ctctcttcct     2220

cagactgtgg ggacagatac aattccactc ctgtccacag gaacatgaga tttagcagac     2280

taaggagatc tgtaaagaat gaaccatacc acaaggcata ctgaagtgag gattataaga     2340

gaaataaact caaaatgctg ttggaatatg cagagaattg ctaccagaat attcagtaag     2400

gtttcaggga gaatgtggca tttgaggact ctcttagaat gagtgattca cctgctattt     2460

aaatgaatta tttagatttt tgacaaagat ttaggtggac accctaaact gtgtgtgcct     2520

ttaaccagtt aaaagaacag tgccttcagc atactttttt attagttgta ggaatacagc     2580

tttttgaaaa agctataaag tttaaattaa ctaaaaatat gcattttctt acacataatt     2640

taaatgttat catacttttt tgatgaaaac ataatgcctt agtaaaatag ctctatttaa     2700

taaagaagat tgagtactct gacacatttc atttaaatta ggaaattttt aatattaaaa     2760

tcccagtgtt ctgagttatt gaaaggcttt cttttatttt gagagcttta ggtctttttg     2820

ggatgagaac attttagttg tttagtttgt ttcttaagca gtgctatttt ttgtaaacac     2880

agataaatgg aaaccattct tttcaatgca gaagaaatct agatatcccc tactgtgacc     2940

aaatttctgt attacgattt tatgttaaat taaactaata tggcaggtta taatgatcct     3000

taagtgtaaa gaaatcagtc aattacaaga gtaattgtat agttattgag acctatagtg     3060

tgtggcttag atgaaaggga gagtaaattt tcataccatg ctctctccta ctcagtttga     3120

tctctctaaa attgtagttt ggtttgattt aatataattc ttagtagaaa ttttgaaagt     3180

atgctttggg attaataatt atttttaatt tttctggctg aatatcaaat tgatagtaac     3240

aacagaagca taattttagg aaggctttcg caaacctagc cttttaagag aggtttttaa     3300

cctgaagcat gagaatatat cacctgtggt ttttcctttg agatgaaacg tagtttctag     3360

ttatatcatt acttaaaggg cttaaaaaga aaaaacttag caaacttttg aatctttctt     3420

ttattgctat ttacacatac atacacacat acaaaacctt taaattttgg gatctgaata     3480

taattctggt aaacagctgt cttcattttt ctcctctaaa gaacttaatt catttgttac     3540

ataaaatata aggaaatctt tatactattt tacagtaacc acaatctaaa tatttacata     3600

tacccaaaat taacttatgc tcatatatta ggatgtgaga atatcatctg tttatggaca     3660

catgaaacct cctaatgacc tggaattgtt agaatatttg actttttata tgcaaagttt     3720

ttcaaccaag tggtttgtct aatatttaaa catgtactgg cacaatttgt gatgaaaata     3780

ttagcacatt tgcaataatg tttctccata acagagaatg ttaatggata ccagaatttt     3840

atttttgtat ttatgttcat agtacttttc ctcttgtcta ctccagacag ttattccata     3900

aagcatttgt ataattaaaa ggaaaacaga aaaaggaaaa gtaggcaaat gtgaaaatag     3960

tttcaatata tcttatgatt tcttaatgta aaatgttttg ttgaagtata tggctatcat     4020

gactaagtgc tagaatttat agttacaggc ggtgtccttt taaatgtgga aaggctttta     4080

aaatatttta aaactggacc tgtattatcc tgaatacact attttgaaaa tttttaaaaa     4140

tgacttcttt attttgcttt accgtatgtt tatatctaat tgacatattg actaatgttt     4200

gaaagaattc aaccataagt taaaatctga aggttatctt tatcatgttt catccctgtc     4260

tgaagatttc ctagtcttct tatgtaaatc acatgactca tgtccgtaaa tgaactatga     4320

aagatatcga tcagtttatg atcattgaca tgtgatttca aaacacagtg ttcttttaaa     4380

aatctataat atgtcaaaat acaagttttt tttttttaca tcgttttagt aagttaattt     4440

catttattta ctttggagct atatttccac ttagaaaaac taaggtaatt ttacaatata     4500

tgctgagatt aaaaaccaag gtaaaaatga tcaaacatat atgaaattga gtcttagatt     4560

taatgaattt cactcgaaaa taaatgatca gaagaatt                             4598


<210> 2306
<211> 842
<212> DNA
<213> Homo sapiens

<400> 2306
ggaaaacagt gtggcatatt ctgctgagct tcgccctgga agaagcctct tttatacatc       60

tcttcaggga agagagaagc aatgggcatg ttagtataca atgatcacag ccacgcaggc      120

ctgcaagctg ccttttggac aggctgttga ctgccgttcc aattagctga ttggagaatg      180

tggaatgcag agtgataatg ctgcatatct gctatcaggc agcagcaaag gtttttgtct      240

tgggaaggca agctttccct gcaatattat ctcagcagct ccctagctgc ttaccctgaa      300

aacgagggat ccaaacggag ggtgttgcac tctgctaacg ctggtcctgt gcgtggctgt      360

ggcatatgag cggcaggtct gaaaaagcag gtgtgtgctg ggacgggcac tggactggaa      420

cgcaggcgga cgctctcggg tttacctgct tcctgttaac agattgtggg ctcccagggc      480

atatgtctgc acgctgaggc cgaggcggag aaggggcttc ctgagcgtcc cagtacactg      540

acagagacac ttggattgga cttaatctta aacctctgga gttcaagacc ttttaaaaag      600

ggctaaataa acaatctcta catgtaaaag gccactgact cctacttcct ctgtatagag      660

caactgttga actcagctgc ctgtagggcg tgattctcag tcaccagact cagcaaaagg      720

ttttagaagc gttcgaccaa acctacaaga taaaagatca ccaactcaga gccagataac      780

agtgaatgga aactcaggag gtgccgtgag tcccatgagt tactatcaga ggccgttttc      840

cc                                                                     842


<210> 2307
<211> 3043
<212> DNA
<213> Homo sapiens

<400> 2307
cattttactt atggaaaaca gtgtggcata ttctgctgag cttcgccctg gaagaagcct       60

cttttataca tctcttcagg gaagagagaa gcaatgggca tgttagtata caatgatcac      120

agccacgcag gcctgcaagc tgccttttgg acaggctgtt gactgccgtt ccaattagct      180

gattggagaa tgtggaatgc agagtgataa tgctgcatat ctgctatcag gcagcagcaa      240

aggtttttgt cttgggaagg caagctttcc ctgcaatatt atctcagcag ctccctagct      300

gcttaccctg aaaacgaggg atccaaacgg agggtgttgc actctgctaa cgctggtcct      360

gtgcgtggct gtggcatatg agcggcaggt ctgaaaaagc aggtgtgtgc tgggacgggc      420

actggactgg aacgcaggcg gacgctctcg ggtttacctg cttcctgtta acagattgtg      480

ggctcccagg gcatatgtct gcacgctgag gccgaggcgg agaaggggct tcctgagcgt      540

cccagtacac tgacagagac acttggattg gacttaatct taaacctctg gagttcaaga      600

ccttttaaaa agggctaaat aaacaatctc tacatgtaaa aggccactga ctcctacttc      660

ctctgtatag agcaactgtt gaactcagct gcctgtagga aaactgaaga ctttaataac      720

aaactctcca aggtgaaaat gaacacaggg cgtgattctc agtcaccaga ctcagcaaaa      780

ggttttagaa gcgttcgacc aaacctacaa gataaaagat caccaactca gagccagata      840

acagtgaatg gaaactcagg aggtgccgtg agtcccatga gttactatca gaggccgttt      900

tccccctcgg catattctct cccagcctca ctcaactcca gcattgtcat gcagcacggc      960

acatccctcg attccacaga cacatatccc cagcatgcgc agtctctgga tggcaccacc     1020

agcagctcta tccccctgta ccgatcctca gaggaagaga agagagtgac agtcatcaaa     1080

gccccgcatt acccagggat cgggcccgtg gatgaatccg gaatccccac agcaattaga     1140

acgacagtcg accggcccaa ggactggtac aagacgatgt ttaagcaaat tcacatggtg     1200

cacaagccgg atgatgacac agacatgtat aatactcctt atacatacaa tgcaggtctg     1260

tacaacccac cctacagtgc tcagtcacac cctgctgcaa agacccaaac ctacagacct     1320

ctttccaaaa gccactccga caacagcccc aatgccttta aggatgcgtc ctccccagtg     1380

cctcccccac atgttccacc tccagtcccg ccgcttcgac caagagatcg gtcttcaaca     1440

gaaaagcatg actgggatcc tccagacaga aaagtggaca caagaaaatt tcggtctgag     1500

ccaaggagta tttttgaata tgaacctggc aagtcatcaa ttcttcagca tgaaagacca     1560

actgatcgca taaatccaga tgacatagat ttagaaaatg agccctggta taaattcttt     1620

tcagaactgg agtttggacg cccgcctcct aaaaagcctc tggactatgt tcaagatcat     1680

tcttctggtg ttttcaatga ggcctccttg tatcagtcct ctatagacag aagcctggaa     1740

agacccatga gttctgcaag catggccagt gacttcagga agcggaggaa gagcgagcct     1800

gcagtgggtc caccacgggg cttgggagat caaagtgcga gcaggactag cccaggccga     1860

gtggacctcc caggatcaag caccactctt acaaagtctt tcactagctc ttctccttct     1920

tccccatcaa gagcaaaaga ccgtgagtcc cctagaagtt actcatccac tttgactgac     1980

atggggagaa gtgcaccaag ggaaagaaga ggaactccag aaaaagagaa attgcctgca     2040

aaagctgttt atgattttaa ggctcagaca tctaaggagt tgtcatttaa gaaaggagat     2100

actgtctaca tcctcaggaa aattgatcaa aattggtatg agggagaaca ccacgggaga     2160

gtgggcatct tcccgatctc atacgtagag aaactcacac ctcctgagaa agcacagcct     2220

gcaagaccac ctccgccagc ccagcccgga gaaatcggag aagctatagc caaatacaac     2280

ttcaacgcag acacaaatgt ggagctgtca ctgagaaagg gagatagagt tattcttctt     2340

aaaagagttg atcaaaactg gtatgaaggt aaaatcccag gaaccaacag acaaggcatc     2400

ttccctgttt cctatgtgga ggtcgtcaag aagaacacaa aaggtgctga ggactaccct     2460

gaccctccaa taccccacag ctattctagt gataggattc acagcttgag ctcaaataag     2520

ccacagcgtc ctgtgtttac tcatgaaaat attcaaggtg ggggggaacc gtttcaggct     2580

ctgtataact atactcccag gaatgaagat gagctggagc tcagagaaag tgatgtcatt     2640

gatgtcatgg aaaagtgtga tgacggctgg tttgtgggga cctcaagaag aaccaaattc     2700

tttggtactt tccccggaaa ctacgtcaag aggctgtgaa ttgcgctccc tccttctgta     2760

gaggccgcct gccagccatg cacctgcgtc aacgcgcctg aaacaccccg cgggcctccc     2820

gttgtcatgc cttacggttt ccaatgcgcc gtcaccatct ccacctgcca ccaaaccacc     2880

agcagagtag ccgccgctgc tgtgagcctg gggacgacat ggcaggctgg tccccctccg     2940

tgaaagtgtg gattcctact tcctgctcta agctttgaca cgtcaaaatg tgggatcaga     3000

aagaaaaaaa tcatgatatt taaaaatggt caaatatttg agg                       3043


<210> 2308
<211> 6400
<212> DNA
<213> Homo sapiens

<400> 2308
aggggcggag gtgacagcgg gctggggact ggcggctgca actgcctgcc gcgccgaggg       60

accgccgggc ggcggaaagc aggttataaa acatggaggc tggctcagtg gttcgagcca      120

tttttgactt ctgccctagc gtatcagaag aactgccgct ctttgtggga gatattattg      180

aggtgctggc agtggtggat gaattttggc ttctaggaaa gaaggaggat gttacaggac      240

aattccccag cagttttgtg gaaattgtga ccattcccag tctaaaagag ggagagaggc      300

tgtttgtgtg catttgtgaa ttcacatccc aagagttgga taatcttccc ctccatcgag      360

gtgacctggt gattctcgat ggcattccca ctgcaggctg gctgcagggc cgaagctgct      420

ggggcgcacg gggcttcttc ccatcttcat gtgtccgcga gctctgcctc tcctcacaga      480

gccggcagtg gcactcccag agcgccctgt ttcagattcc ggaatattcc atgggacaag      540

cccgggccct aatggggctt tctgctcagc tggatgaaga gctggacttc agggaagggg      600

atgtgatcac cattattgga gttcctgaac caggctggtt tgaaggggag ttagagggcc      660

gaagaggcat ttttccagaa ggttttgtag agctgttggg gcccctgagg actgtggatg      720

agtcagtaag ttctggaaat caagatgact gcattgttaa tggtgaagta gatacccctg      780

taggagaaga agagataggg ccggatgagg atgaggagga gccagggacc tatggggtcg      840

ccctgtacag attccaagcc ctggagccaa atgagctgga tttcgaggtc ggggataaaa      900

tccgaattct ggcgaccttg gaagatggct ggctggaagg atccctgaag ggcaggacag      960

gcatctttcc ttaccggttt gtgaaattat gtcctgacac acgggtggag gaaaccatgg     1020

ctctgcccca ggaaggcagc cttgccagga tcccggaaac ttctttggat tgtttggaga     1080

acaccttagg agtagaggaa caaagacatg aaaccagtga ccatgaggcc gaggagcctg     1140

actgcattat ttctgaagca cccacttctc ccctcggtca tctgacttca gagtatgaca     1200

cagacagaaa ctcttatcag gacgaggaca ccgcaggagg gcccccgaga agcccaggcg     1260

tggagtggga aatgcctctt gccacagact ctcccacatc tgaccctaca gaagtagtca     1320

atggtatttc ctcccaacct caggtccctt ttcatcccaa cttgcagaaa agccagtatt     1380

attctacagt gggagggagc cacccgcact cagaacagta ccccgacctt cttcccctag     1440

aagcaaggac tagagactat gccagcctac ctcccaaaag aatgtattcc cagctaaaaa     1500

ctcttcagaa gccagtgctc cctctttaca ggggctcttc tgtttcagct tcaagggtag     1560

tcaaacccag acaatcaagt cctcagctcc acaacctagc aagttatact aaaaagcacc     1620

acacgtccag tgtttactcc atctcagaga gattggagat gaagcctggt ccgcaagccc     1680

aagggcttgt tatggaagca gcaacacatt cacagggaga cggcagcact gacctggact     1740

cgaagctgac acaacagctg atcgagtttg agaagagctt ggcagggccc ggcacagagc     1800

cagataaaat tttacgccac ttttcaatca tggactttaa ctctgagaag gatattgtcc     1860

gaggttcctc aaagttaatc accgagcagg agctgccgga aaggagaaag gccctaaggc     1920

caccgccacc tcgtccctgt actccggtat ccacttctcc ccatttgctg gttgaccaga     1980

acctaaaacc tgcaccaccc ttggtggtgc gaccctctcg cccagctccc ctgcctccct     2040

cagcacagca gagaacgaat gcggtatccc ccaagctcct atctcgacac cgtcctacct     2100

gtgagacctt agaaaaggag ggccctggtc atatgggaag gagtctggac cagacctccc     2160

catgcccctt agtgctggtg aggattgagg aaatggagcg ggacttggat atgtacagta     2220

gagctcaaga agagctaaac ctcatgctgg aggagaagca ggatgaatca tcaagagcag     2280

agaccctcga ggatctcaag ttctgtgaaa gtaacattga aagtttgaat atggaactcc     2340

agcaactaag agaaatgacg ctcctctcct cccagtcttc atcactggtg gccccttctg     2400

ggtctgtgtc tgccgaaaat ccagagcaga ggatgctgga gaagagagcc aaggtcatag     2460

aagaacttct tcagacagaa agagactaca ttcgggatct ggaaatgtgt attgagcgga     2520

tcatggtacc catgcagcag gcacaggtac caaacattga ttttgaggga ctttttggaa     2580

atatgcagat ggtgattaag gtctcgaagc aattattggc tgctctggaa atcagcgatg     2640

ctgtaggacc tgtgtttctt ggtcaccggg atgagcttga gggaacatac aagatttact     2700

gccagaatca tgatgaggcc attgcgctgc ttgaaatcta cgagaaggat gagaagatcc     2760

agaagcatct tcaggactcc ttggcagatc tgaactcttt agttctaaaa aagggatgca     2820

caaattatat taacctgggc tccttcctca tcaaaccagt acagagagta atgcgttacc     2880

cgctgttgct aatggagttg ctgaattcca ccccagaatc ccacccagat aaagtgcctt     2940

taaccaatgc agtccttgcg gtcaaggaaa tcaacgttaa cattaatgaa tataaacggc     3000

gaaaggacct ggtcctcaag taccgtaagg gtgatgaaga tagccttatg gagaaaattt     3060

ccaaactgaa catccactcc atcatcaaga aatccaaccg agttagcagt cacctgaagc     3120

atctcactgg ctttgctcct cagataaaag atgaagtatt tgaagaaaca gaaaaaaact     3180

tccgaatgca agaaagattg attaagtctt ttatccgaga cctgtctctc tacctccagc     3240

acatccggga gtccgcatgt gtgaaagtgg tggctgctgt gagcatgtgg gatgtgtgca     3300

tggagagagg acaccgggac ctggagcagt ttgagagggt gcatcgctac atcagtgacc     3360

agctcttcac aaactttaag gagaggacag agcggcttgt catctccccc ttaaatcagt     3420

tactgagcat gtttacaggg ccccataagc tggtacagaa acgctttgac aagctcctgg     3480

acttctataa ctgtacagaa cgggcagaaa agctaaagga caagaagacc ctggaggagc     3540

tgcagtcggc ccggaacaac tatgaggccc tgaatgcaca gctgctggat gagctgccca     3600

agttccacca gtacgcccag ggcctcttca ccaactgtgt ccacggctat gctgaagccc     3660

actgtgactt tgtgcaccag gctctggagc aattaaagcc actgctttcg ttactcaaag     3720

tggctggcag agagggaaac cttattgcca tcttccacga agagcacagc agagttctgc     3780

agcaactcca ggtttttacc ttcttcccgg agtctcttcc agctaccaag aagccatttg     3840

agaggaaaac cattgaccgc cagtctgctc gaaagccact cctgggcctg ccaagttaca     3900

tgctacagtc agaagaactc cgggcctccc tcctggccag gtatccccct gaaaaactct     3960

tccaggcaga acggaacttc aatgctgctc aagacttgga tgtctcactt ttggaaggtg     4020

acctggtggg tgtgattaag aaaaaagacc ccatgggcag ccagaaccgc tggctgattg     4080

acaatggagt caccaaaggc ttcgtgtaca gctctttcct aaagccctac aatcctcgcc     4140

gcagccactc cgatgcctcc gtgggtagcc actcctccac agagtctgag cacggcagct     4200

cctcccccag gttcccacgc cagaacagcg gcagcaccct gaccttcaac cccagcagca     4260

tggctgtatc ctttacctcg gggtcttgcc agaagcagcc tcaagatgca tctcctccgc     4320

caaaagaatg tgaccaagga actctcagtg catccctaaa tccgagtaat tcagagagta     4380

gtccttccag atgcccttca gacccagact ccacctccca gccaaggtca ggggactctg     4440

cagatgtagc tagagatgta aagcaaccca ctgccacgcc gaggagctac cggaacttca     4500

ggcatccaga aatagttggc tactccgtac caggacgaaa tgggcaaagt caagacctcg     4560

tcaaaggatg tgcaagaaca gcccaggctc cggaagacag aagtacagag ccagatggca     4620

gtgaggcaga aggcaaccag gtctattttg ctgtctacac cttcaaggca cgaaacccaa     4680

atgagctgag cgtgtcagcc aatcagaaac tcaagatcct cgagtttaaa gatgttacag     4740

gaaatacaga gtggtggtta gctgaggtta acgggaagaa gggctacgtt ccctccaatt     4800

atatccgcaa aaccgagtac acctgagccc acgttgcctg ccacccagcc ttgctgcctt     4860

tgctttcagt ccgccgaggg ttctggcggc ccaccgagag ggcgcctgct cctgagacac     4920

aggccctgtc tgcgttgctt aaccatggca tggtggagca caccacagat cttgttctcc     4980

tcgattgggt tgtaaacctt gatgctcact agaatctcta gaatttgaaa tggaccctgg     5040

ggctttgcaa atgacttagt gactatgaga agagagacaa gtcttagagc tggcttttgg     5100

aaaggagaaa cttgcagtca gaagcccagt gtcctatgta tgcaggaagc tgtgctctag     5160

caatagacag tgttggtaat ggttgtgctg tacggcgttt ggggtggccc catgttccat     5220

gctcagctga ccggatgcca actcagatga aaagaattca tggctctggg caccccgtga     5280

ggcagtgctt gcacatggct gggagtttgt cgggattgaa ccaaacctag tgcttcaaag     5340

ctcctgggac acctccagtg tccagcacac attctcatac atactgcccc taatttctaa     5400

agtccctaaa gcactacatt ctgtaacctt gtttctttta ctccattccc agattagtta     5460

tgcaaaattc aactgcgttc tacttttaga agtgtttagg gtctttattt tctgttgacc     5520

cttcatctga aagattctct tcccttgtta ggtacaatca ctgccccccc gctttttttt     5580

ttgagatggg gtcttgctat gttgcccagg ctggtcttaa acgcctgggc tcaagcaacc     5640

ctcccgcctc cctgctgaga ttacaggtgt aagccaccat accgcaacct caatgacacc     5700

tttctgatgg tctttacaca gtctgtgatg tctggtggcc cccctgccct ggactcaata     5760

attgatagat tttcctagag taacagtatg agagctccag ccattccatt aaaagtatta     5820

gttctgcttt gagctgaaac cagttgagcc taatggaaga ctggatgtct ttcttcttca     5880

tccaagcacc ctaatgactg tttagttaca tccatagatg cagacaacat aacacctgtg     5940

acttacttga attgggataa gccattccag aagtagctta tcctagactt ggaaataaga     6000

tttttttcac cactaacttc catgcttcag agatgacatt caaagccaga ttcccaagtg     6060

cctgatcata cctcccagtc tcaggaagat atttgcttac cccttagacc aagaatctta     6120

agatcttccc cagctatgaa gcctatcttg gaatgggaaa ccatgaaatt tgtcttttaa     6180

aagaaaggga agaaatagcc ttacagcccc tgttcctcca agtgcacatt tagccttaaa     6240

atcctgggag tcgggagaca ccgtggagtc ctaacatcca cagtgtctgc tggtcgtggt     6300

cagaaggcag taatgcaaga gtccttttgt gaagagtgtt tctatgtaga gatgtttata     6360

tttaagtagt tcttttataa ataaaagcat ttctaatggc                           6400


<210> 2309
<211> 3132
<212> DNA
<213> Homo sapiens

<400> 2309
gtggtttggg gaaagtgtag gggcaaccaa agatcatcgg cttgactagg ccctttgccc       60

tgaacctcat gaagaaatga taggaggcag acatatgtgc ctaaaaagag cgttgagctc      120

agagaagagc aactcggagt tttgggggtg tgctttgatt tgtgtacatc aatggcagaa      180

tcatccagcg aatcagatca cttccgctgt cgtgaccgat tgagtccatg ggctgccaga      240

tcaacgcaca ggggaactcg aagtcttcct acagtagaag ttaccgagaa ggtcaacact      300

ataacaagta ctttacagga taccagtcgg aacctgcgac aagtggacca gatgcttgga      360

cgataccgag aatacagtaa tggacaggcg ggtgcgatag aacatttaaa agaaagcttg      420

gaacaatcaa tcgaccaact ccggagtcaa cgtttattga gaaactcagg agggagaagt      480

atttctgtta caagtttgag tgcaagtgac cttgatggtg gcactgggtc agagctccat      540

cattttccac ctacctcacc tctcaaggac tatggggatc cacagggtat taaacgaatg      600

agatcaagaa ctggtgtccg gtttgttcaa gagactgatg atatgactca gcttcatggt      660

tttcatcagt ctcttcgaga cctcagcagt gaacaaattc gccttggaga tgatttcaac      720

agggagcttt ccagaaggag ccggtcagat gccgaaacaa aaagggcttt ggaagaattg      780

actgaaaaac ttaatgaagc ccagaaacaa gaagtggttt cagatcgggt ggagcggcgg      840

cttcaggaac tggagagaga gatgcgcaca gaaagggagc tggtggaaag acgccaggat      900

caactgggac tcatgtccct gcagctacag gaggcactaa agaaacaaga agctaaagca      960

gatgagcatg agggggcaat aaaaaataag ctaagacaaa ctgaaactga gaagaatcaa     1020

cttgaacagg aattggagct atctcgaagg ttattgaatc aatcagaagg cagccgagaa     1080

acacttttgc atcaggtaga agaactgcgt acacaactta cgaaagcaga aggtgatcga     1140

aagggtttac agcatcaagt atctcagatt tccaagcaac agtcaaacta tcaggatgaa     1200

caaggggagg actggagatt taggagaggg gttgagcggg aaaaacagga cctggagaag     1260

caaatgtcag atttgagagt gcagctgaac ttcagcgcaa tggcatctga gttagaggaa     1320

gtgaaacggt gcatggagag aaaagacaag gagaaagcac atttggcatc acaagtagag     1380

aatttaacac gtgaactgga gaatggggaa aaacagcaac tgcagatgtt ggatcgactt     1440

aaggagatcc agaatcactt tgacacatgt gaggccgagc gtaagcatgc tgaccttcag     1500

atctcagagc tgactcgcca tgcggaggat gcaaccaagc aggctgagcg gtacctcagt     1560

gagctccagc agtcagaggc tctgaaagag gaggcggaga agaggaggga agacctgaaa     1620

ctgaaagctc aagaatccat taggcagtgg aagcttaagc ataagaagtt agaacgagcg     1680

ttggagaaac aatctgaaac tgttgatgaa ctgacaggca agaataatca gattttaaaa     1740

gaaaaggatg aattgaaaac ccagctgtat gcagcattac aacaaataga gaatcttcga     1800

aaggaattga atgatgtcct aacaaagcgt gcccttcagg aggaggagct tcactccaag     1860

gaggagaaat tacgtgatat taagtctcat caagctgacc ttgaattgga agttaagaat     1920

tccctggata ccatccatag actggagagc gaattgaaaa agcagagtaa gatccaaagc     1980

cagatgaaag ttgagaaagc tcacttggag gaagaaattg cagagctcaa gaagagccag     2040

gcccaggaca aagctaaact tcttgagatg caagagtcca tcaaggacct gagtgccatc     2100

cgagcagatc ttgctaataa attggctgag gaagagagag ccaagaaagc agtgcttaag     2160

gacctttctg acctcactgc acaggcaaaa tccagggatg aagaaacagc tacaatcatc     2220

acacagttaa agctggaacg agatgtgcac cagagggagc tgaaagatct cacatcatca     2280

ttgcagagtg tgaaaacaaa acacgaacag aatatccagg agcttatgaa gcactttaag     2340

aaagaaaaga gtgaggctga gaatcatatc aggactctga aggctgaaag tttagaagag     2400

aagaatatgg ctaaaattca tcgtggtcag ctggagaagt tgaaatcaca gtgtgacaga     2460

ctgacagagg aattaaccca gaatgaaaat gagaacaaaa aactgaagct aaaatatcaa     2520

tgtttgaagg atcaactaga agaaagggaa aaacatataa gcattgaaga ggagcactta     2580

aggaggatgg aagaggccag attgcagctc aaggatcaac ttctttgctt ggagactgaa     2640

caggaatcca ttcttggtgt gataggaaag gaaattgatg cagcttgtaa aacattctcc     2700

aaggactcag tggagaaatt aaaagttttt tcatctggtc ctgatataca ttatgaccca     2760

catcgctggt tagcagaaag caagactaaa cttcagtggc tctgtgagga actgaaagag     2820

agagaaaaca gagagaaaaa tctgcgacac cagctgatgc tctgcagaca acaactcagg     2880

aatttgactg aaaacaagga atctgagttg cagtgtctct ttcaacagat agaaaggcag     2940

gagcagcttc tggatgaaat acatcgtgag aagagagatc tactggaaga gacccaaaga     3000

aaagatgaag aaatgggatc tctgcaggac cgtgtaattg cattagaaac gagtacccaa     3060

gtggccttgg accatctgga gtctgtgcct gagaaactga gcctactaga agatttcaaa     3120

gacttcagaa ga                                                         3132


<210> 2310
<211> 10382
<212> DNA
<213> Homo sapiens

<400> 2310
attgtgggcg actcggctaa tggcgtcggc gagtcttagg ggcctgggga gctggcgctg       60

aagcttcttg ccaggttggc tggtgacacc cggtgtggct gggccccgcg gcagcggagg      120

gacctgcccg ccttgtgggt ttctcggcca gagtcggcgg agcctagcgg gacggtgcga      180

ctgcgggggg cgcctccgag aaaagccaga ggtgttgcgg ggaagctgct gggggacgct      240

cgagcaggct ccgggttcgc agcccagggc ccaagaagcg ggctgctgaa ggaccagaga      300

caccgggagg gagctgcctg tggccctaag gagctgaccg tgccagagct tgtttgtacc      360

tctcggaaat tggctgggac cttggaggat catgtccggc accagcagcc ccgaggcggt      420

gaagaagctg ctggagaata tgcagagcga cttgcgcgcc ttgtcactgg agtgcaagaa      480

gaaattccca cctgtcaaag aggctgctga atcaggaata ataaaagtta aaacaattgc      540

tgcacgaaac actgaaattt tggcagcact gaaagagaac agctcagagg ttgtacagcc      600

ttttttaatg ggttgtggaa ccaaggaacc gaagatcact cagctatgtt tggctgctat      660

tcagagactc atgtcacatg aagtcgtgtc tgagactgca gctggaaata taattaacat      720

gctttggcag ctaatggaga atagtcttga agaacttaag ctacttcaaa cagttcttgt      780

tcttttaaca accaatacag tagttcatga tgaggcactt tctaaggcaa tcgttctttg      840

ttttcgacta cacttcacaa aagataatat tacaaataat acagctgctg ctacagtgcg      900

acaagttgtt actgttgttt ttgagaggat ggttgctgaa gatgaacgac acagagatat      960

tatagaacaa ccagtactgg tacaaggaaa tagtaacaga agatctgtca gtaccctcaa     1020

accttgtgct aaagatgcat atatgctttt ccaggatctt tgtcagttgg ttaatgctga     1080

tgctccttat tggctagtgg gcatgacaga aatgactcgg acgtttggcc tcgaattact     1140

tgagtcagtc ctcaatgatt ttccgcaggt ctttttacaa caccaagaat ttagtttcct     1200

cctcaaagaa agggtatgtc ctcttgtgat aaagctcttt tctccaaata taaagttcag     1260

acaaggttcc agcacctcat cttctccagc accagttgaa aaaccatatt ttcctatctg     1320

catgcgtttg ctgagagtag tatctgttct gattaagcag ttttacagtc ttttggtaac     1380

tgaatgtgag atatttctgt cacttctggt gaaatttctg gatgcagata aaccacagtg     1440

gctacgagct gttgcggtgg aatcaataca cagattctgt gtgcagcctc aactattaag     1500

gtcattttgt cagtcctatg atatgaaaca gcattctacc aaggtttttc gtgatattgt     1560

aaatgcactg ggatctttta tacagtcctt gtttcttgtc ccccctactg gaaatcctgc     1620

aacaagcaac caagctggaa acaataattt aggtggctca gtctcagcac cagctaactc     1680

aggaatggtg gggattggtg gaggtgttac tttgctacca gcatttgaat ataggggaac     1740

ctggatacct attctgacaa tcacagttca aggcagtgct aaagccacct acttagaaat     1800

gttggacaaa gttgagcctc caactatacc tgaaggttac gccatgtctg tggcattcca     1860

ttgtttgcta gaccttgttc gtggaatcac aagtatgatt gaaggagagc taggagagct     1920

tgaaacagaa tgtcaaacca ccactgaaga aggttcttca ccaacacagt cgacagaaca     1980

gcaggattta cagtcaacat cagaccaaat ggataaggaa attgttagta gggctgtttg     2040

ggaagaaatg gtgaatgcct gctggtgtgg tcttcttgct gcactctcac tccttcttga     2100

tgccagcaca gatgaagctg ccactgagaa tattttaaaa gctgaactga ctatggctgc     2160

tctttgtgga agactgggcc ttgtaacttc aagagatgcc tttataactg caatatgcaa     2220

aggttccctg cctccccatt atgctcttac tgtattgaat accaccactg cagctacact     2280

ttccaacaaa tcatattccg ttcagggcca aagtgttatg atgataagtc catcaagtga     2340

atctcaccaa caagttgtgg cagtgggtca acctttagca gtccagcctc aagggacagt     2400

aatgctgact tccaaaaata tccagtgtat gaggacttta cttaacttgg cgcattgcca     2460

tggggctgtt cttggaacat catggcaact tgtcttggca actcttcagc atcttgtgtg     2520

gattctggga ttaaagccta gtagtggcgg tgccttgaaa cctgggagag ctgtagaagg     2580

acccagtaca gttctaacaa cagcagtgat gacagattta ccagtgattt ccaatatact     2640

ttcaagattg tttgaaagct cacagtatct tgatgatgta tcactgcatc atttaataaa     2700

tgcactttgc tccttgtctc tagaagcaat ggatatggcc tatggaaata ataaggaacc     2760

atctcttttt gctgttgcca aattgttaga aactggttta gttaatatgc accgaataga     2820

aattctgtgg agacctctga ctggccatct acttgagaag gtctgccagc atccaaactc     2880

tcgaatgaga gaatggggag cagaagcttt aacttctctt attaaagcag gattaacatt     2940

taaccatgat cctccactct cacaaaacca gaggctgcag ttgcttttat tgaacccgtt     3000

aaaggagatg tccaatatta atcatccaga tattcgactc aagcagttag aatgcgtgtt     3060

gcagattctg cagagtcagg gagacagtct tgggcctgga tggccattag tgcttggagt     3120

catgggagca atcagaaatg atcaaggaga atccttgata cgaactgcat tccagtgtct     3180

tcagttggtt gtgacagatt ttctaccaac aatgccttgt acttgcctgc aaatagttgt     3240

agatgttgca ggtagctttg gcctccataa ccaagaactc aatattagtt taacttcaat     3300

aggtttattg tggaatattt cagattattt tttccaaaga ggggaaacta ttgaaaaaga     3360

actaaataag gaagaggcag cacagcaaaa gcaggcagaa gagaaaggag ttgttttaaa     3420

tcggccattc caccctgcac cgccatttga ttgcttgtgg ttatgtcttt atgcaaaatt     3480

gggtgaacta tgtgtggatc cccgtcctgc tgtcaggaag agtgcagggc aaactctgtt     3540

ttctacaatt ggtgcgcatg gaactttatt acagcattca acctggcaca ctgttatctg     3600

gaaggtactc tttcatctac tggacagagt tcgagagtcc tctaccactg cagacaaaga     3660

aaagattgag tctggaggtg gcaatattct cattcatcat tcaagggaca ccgccgagaa     3720

gcaatgggct gagacgtggg tattaacatt ggctggagta gcaaggatct tcaacactag     3780

aagatatttg ctgcagcctt taggagattt ttcaagagct tgggatgttc ttcttgacca     3840

tatacagtca gcagcactca gcaaaaacaa tgaagtatct ctggctgctc tgaaaagctt     3900

ccaggaaatt ttacagattg tgtcccctgt cagagactca gataagcctg agacaccacc     3960

tgtagttaat gtacctgtgc ctgttcttat agggcccata tcaggcatga gcaggccatt     4020

tgtaagaaca gattccattg gagaaaaact aggaagatat agtagctctg agccacccat     4080

tgttactgat gagcttgaag atttgaatct atggtgggct gcgtggaata cctggtatag     4140

aattggatct gaaagtacta agcctcctat tacttttgat aaactaactt ttattcctag     4200

ccagcctttt cttacagctt taattcagat atttccagct ctctaccaac acataaaaac     4260

tggtttcaat atggatgact tgcaaaagtt gggagtcata ttgcacagtg ctatttcagt     4320

cccaataagt tcagatgcat ccccttttat tcttccatct tataccgaag cagttttgac     4380

aagtttacag gaagctgtac ttacagcttt agatgttctc caaaaggcca tttgtgtagg     4440

accagaaaac atgcagataa tgtatccagc tatatttgac cagttgttgg catttgtaga     4500

attttcctgt aaacctccac agtatggaca gctggaaaca aagcacattg caaatgcaaa     4560

atataatcag atccaactat ttgcaccggc ggaatgggta gccttgaatt atgtgccgtt     4620

tgctgaaagg tctttagaag tagttgtgga tttataccaa aaaacagcgt gtcacaaagc     4680

agtggtgaat gagaaagtgc tccagaatat tattaagact cttagggttc ctctcagttt     4740

gaagtattcc tgcccttctg aaagcacatg gaaactagca gtatcctctc tcctcagagt     4800

tctttctatt gggctacctg ttgcccggca gcatgcttct tctggaaaat ttgacagtat     4860

gtggccagaa ctagccaata cttttgaaga ttttctcttt actaaaagca tacctccaga     4920

taatctctct attcaagagt ttcaaagaaa tgaaaatatt gatgtcgagg tagttcaact     4980

tatcagcaat gagatactac cttatgccaa ttttattcct aaggaatttg ttggtcaaat     5040

aatgacaatg cttaacaagg gctcaataca ttctcagtca tcttcattta cagaagcaga     5100

gattgatatt cgtttgagag aggaattttc taaaatgtgt tttgaaacat tactccagtt     5160

ttccttcagt aataaagtca caacacctca agaaggctac atctcacgaa tggcactctc     5220

agtgctttta aagaggtccc aagatgtact acatcgctat atagaggatg aaagattaag     5280

tggtaaatgc cctcttccaa ggcaacaagt aacagaaatt atatttgttt taaaagcagt     5340

cagtactctt attgattcac ttaagaaaac tcagcctgag aatgttgatg gaaatacctg     5400

ggcacaagta attgccttat acccaacttt agtagaatgc atcacctgtt cttcttcaga     5460

agtctgttct gcacttaaag aggcactagt tccttttaag gatttcatgc agccaccagc     5520

atccagagtt caaaatggag aatcttgacc ggctacaata tatttgaaag caggaagata     5580

gtctaaaaaa tgtttgctcc taattgagtc ttctgtgaga aggacatttc ttactgcaga     5640

taattcttgg cagctgttgt tggcctcctt taaattctac ttacctgagt tcagtaattc     5700

atattacagg cttgcacatc aacaaaggct cctgaatgaa cagcagtgta aggctttaat     5760

aaattaaact gatgggaggg ataattaaca ctacagtata catgctacca tatctccagt     5820

tggtgattta aagtgagctt atgtacagtt tgtggtgtat gtgttaatga tgtacttttt     5880

aaaaagaaag aagagatatt tcaattcagt cagatttatt agtctggtgt ttttgcaccc     5940

tttttcaagt acaaaatcgt actagaattt tatgcaagat ggtactgtaa cattccatat     6000

tatctataac cagcctttgt taacaaaggg aactgatata cttgtgtgta taataaatgg     6060

tacagttctg tataaaatag tgcatttatt taaattttaa aagtattgat aatgttaaat     6120

gcttaaagct ctatttatta ttaatacaaa attgtttgct tacattttta cttataattt     6180

gccttcatat gtggcggata agctcaccat atgatcatgc agttagcttc atgcttattt     6240

taaatgtatt attagtgacc attaaacatc tgaccagtaa ggtcatgtga acacagcagc     6300

aaatagttta tgatttgctg attttggagc tttgaaatat aggttcttaa tacattgata     6360

catattgtag cactatgact tcatcatacc tcatttcttt aaacagctct ccaagctttc     6420

actgaagtct gtctgttttt tatattggct gtctggattt taaagacttt tcatatttta     6480

tatttctact gattttgttt cccctaacaa catttgtcac tgtctttgaa ttatgaccca     6540

ggcaagatga tttcagattt tctaaaatct tgcctgtgag gttttgttca tatcagtgct     6600

tcattttgta atgtcttctc aagaaaaata cctatgttaa ctcacaagta taaaatatgt     6660

gtgtattata aaacaatgaa aagtgtattt ttggagatag tcaagcattt agaagtgcag     6720

tgaacttgct gtcacggagt aaaatgctaa ttatgtttca ctttcctagc ctagtgaaaa     6780

agaaaagtgc tcttgagtac aataccttaa ttatttctta aaatactgac tttgacctag     6840

ctcactgtat tttttattta atggattatg gattacagta tttttcttct gagttaaatt     6900

ttcataattt atgtgaagac acaaagatgt ttaaaacaat gattattcat aagaaatcat     6960

gatggtctca gtattatttt agtgtattgg aaggtctttg atcttaatag aatttataaa     7020

tttcagcttc tccagaataa tcataaaact gcaaaaagat attataattg agtcatgatt     7080

gagatacagt tttgaggcta ttataattgt ataattattt aatttgcatt atctgtaaaa     7140

tgtagtaagg tctttgaggg gatatttttt atttacatga attactgaat ttctatttta     7200

ttatttcacc taaaattaag gtaaaatatg gcatttcata agttctgctt tcagcatttt     7260

ccttaaagtt gtaaaaaatc aagctatgta cttattttct atatttgggt gtgttaaatt     7320

gaggattaga aaaatccaca taatcactga taaagcattg aaacagaata acccaagggt     7380

agtgtaccga ttcagtaaca tgttaaaaat attgctatgc atttattcaa aggaaaatgg     7440

tctgttcttg agaaataaaa gatcagttgc aattaggata attaaatagt taaatatgag     7500

tcaagtgtat gcaatataca tttatatgaa ccaaagcttg ctttatcagg accatgccct     7560

acagttcaaa acataaacat agtgaatgtg ttaatatcat ataataaggt aataaatgcc     7620

agtcttagtg tgaagcaagt gggtggcccc cttggtagta taattggaca ggattttcct     7680

ccagaatatt tcctgtcacc ctccaagagt cactacagta attgattgct ggcatggaac     7740

acattgccct tgtcttgtta gtatgaattg ggttctccag tgactagaag aactggggtg     7800

tgtgaaagta ttcgatgcca ggagattcaa aaaggaagct ctcaaagata agatcatttt     7860

atggcacaat tgagtctata accagccctt taagcagtag taaaaatgtc ctttgtcata     7920

cttactagaa atactatgag tttttttttt ttttttcatt tgagacggag tctcgctctg     7980

tcacccaggc tggaatgcag tggcacgatc ttggctcact gcaacctctg cttcccgggt     8040

tcaagcagtt tcctgcttca gacttccaag tagctgggat tacagacatg ccaccatgcc     8100

aggctaattt ttttaatatt tttagtagag atggggtttc accattttgg ccattctagt     8160

cttgaactcc tgacctcagg tgatctgccc gccttggcct cccaaagtgc tgacattaca     8220

ggcctgagcc actgcgccca gccaatacca tgagttttaa gcctcacatc gtcacttgct     8280

gtcactgcca gtgcctgttt tattcatatt gctggacaac agacatatgc caccaattgt     8340

atgattaata aagtcttttt ctggccattt tgtccattat aaaggaaata aactaattgt     8400

taacttgcat agattacttc ttagtttcct atgctaccac cactgccaag ggagaaaaaa     8460

atacatcatt ttgtaatgtc tttagtattt ctttataact agtgttaagg ttttgttaat     8520

tttattgtat acatttgtaa catttattag gagcctttta ggttccaaaa caaacaaaag     8580

gcataaaaaa gtctagctta gaaccacttt tcacttgctt tcatttttaa ttttattcac     8640

ttaacagcta acatctttct tgtttcttgt tttttccatt atatggttat cgattcaact     8700

cttgctatat tccttaaatt tgtatgtatc atcagaagaa agagatgaac aatttagtgt     8760

agatatttta ttctggagaa taatattcaa ttaaattatt tctacagcag gccagtaaca     8820

actagattat ttgtcctttc tcagtataat tttaaagagc attttgtttt attgtcacaa     8880

tttggtacca ctagtcccag gtaaccattg ggccaaagga tcagttgaga aacagttaag     8940

gatgaattag cataagttat ggaacagtgt tagaaaacaa ctcaaaagta tattctttat     9000

taatgaggtg gtcattatta catttgtgtc aatgaagggc agtgtagtta ttttaaaatg     9060

actaatattt tctccccaaa tacagaataa ttcagatggg caaccaagtt ttcaagagac     9120

tgctgtaggt gaagtctgtc tagccaaggc agaacactta caggagtccc taactgtgcc     9180

acccttggaa tgggttagtg tacaggctca gaatattgtg gattacagtt tttcagagaa     9240

aactaccaca gatgtagaca aaaatgatct ctgaaagcat tgccagcagc caggtatgtt     9300

ccttagattt ccacttaggt ttggcatttt ggcagataag ctaatcttgt ataaagcatc     9360

acattttact atgcttagtg ttcctgggtt gtatttatct acattattag agggaatttt     9420

tattttaaaa aaattgtcat tcatgagaag aatgggagtt catgccacat agtattttac     9480

caatttatat aaagtgggaa aagtctttaa tacttcatga tcacttgaat taaagttttt     9540

gtatctctgg aaagtagaat agtgctttca tttgaatgaa aagtgtttat agattcagaa     9600

agagagatga tatctttgta tcttgattta tatacagacc atttcagagg aagttaaatg     9660

tcttacaaat ccaatacttt ctaatgctct aacagtgttg gctatttaaa agaacatgtg     9720

gcaagttcta tatgaatatt cttggtcatc tcgactaatt ctgaggcaat gatggacaga     9780

gatgctactt cttatttaac tctaggcatg ttgacttttc aaagcggttt ccttatttct     9840

aaacagagat gatgatcaat gagttactaa ttctttagag gaaaaaatgc ataatttgag     9900

tgtggagttg attttaatga cagggtaatt caagttgttt gataaattta ttactatatt     9960

gtaagagaga tctttgacca tttttcttcc tttttcttgg acatcacttt cttccctccc    10020

cttctctctt ttatgttttt atccttgtta aattttatgt ttacgttacc atctttctta    10080

tactttcccc tgatttttct cttttaattc ctctttcatt ctctgcctct tctctttcag    10140

ctctttctct aattgtgcct attccttgtt cataagaagt ggagctgtta gtggtagaac    10200

cactgctcat ggttctacca ctacaaagtg gaaagtagaa atactttgca ctttggccac    10260

tgttgcgttt ttgccaaggt aaagttcccc tgccattttg aaatagctga acaagttaaa    10320

gtaatatgtt ccaaaaactg gaagtgccat aaaaaactaa aaataaaaaa aaattgtgac    10380

ta                                                                   10382


<210> 2311
<211> 3650
<212> DNA
<213> Homo sapiens

<400> 2311
ggcggagcga gtggaggctg cagcccagct cgtctcggcg cccgcgtcgc cgtcgcgaag       60

ccccccgccc cgcttccgcc gcgtcggaat gagctcccgg aaagtgctgg ccattcaggc      120

ccgaaagcgg aggccgaaaa gagagaaaca tccgaaaaag ccggagcctc aacagaaagc      180

tcctttagtt cctcctcctc caccgccacc accaccacca ccgccacctt tgccagaccc      240

cacacccccg gagccagagg aggagatcct gggatcagat gatgaggagc aagaggaccc      300

tgcggactac tgcaaaggtg gatatcatcc agtgaaaatt ggagacctct tcaatggccg      360

gtatcatgtt attagaaagc ttggatgggg gcacttctct actgtctggc tgtgctggga      420

tatgcagggg aaaagatttg ttgcaatgaa agttgtaaaa agtgcccagc attatacgga      480

gacagccttg gatgaaataa aattgctcaa atgtgttcga gaaagtgatc ccagtgaccc      540

aaacaaagac atggtggtcc agctcattga cgacttcaag atttcaggca tgaatgggat      600

acatgtctgc atggtcttcg aagtacttgg ccaccatctc ctcaagtgga tcatcaaatc      660

caactatcaa ggcctcccag tacgttgtgt gaagagtatc attcgacagg tccttcaagg      720

gttagattac ttacacagta agtgcaagat cattcatact gacataaagc cggaaaatat      780

cttgatgtgt gtggatgatg catatgtgag aagaatggca gctgaggcca ctgagtggca      840

gaaagcaggt gctcctcctc cttcagggtc tgcagtgagt acggctccac agcagaaacc      900

tataggaaaa atatctaaaa acaaaaagaa aaaactgaaa aagaaacaga agaggcaggc      960

tgagttattg gagaagcgcc tgcaggagat agaagaattg gagcgagaag ctgaaaggaa     1020

aataatagaa gaaaacatca cctcagctgc accttccaat gaccaggatg gcgaatactg     1080

cccagaggtg aaactaaaaa caacaggatt agaggaggcg gctgaggcag agactgcaaa     1140

ggacaatggt gaagctgagg accaggaaga gaaagaagat gctgagaaag aaaacattga     1200

aaaagatgaa gatgatgtag atcaggaact tgcgaacata gaccctacgt ggatagaatc     1260

acctaaaacc aatggccata ttgagaatgg cccattctca ctggagcagc aactggacga     1320

tgaagatgat gatgaagaag actgcccaaa tcctgaggaa tataatcttg atgagccaaa     1380

tgcagaaagt gattacacat atagcagctc ctatgaacaa ttcaatggtg aattgccaaa     1440

tggacgacat aaaattcccg agtcacagtt cccagagttt tccacctcgt tgttctctgg     1500

atccttagaa cctgtggcct gcggctctgt gctttctgag ggatcaccac ttactgagca     1560

agaggagagc agtccatccc atgacagaag cagaacggtt tcagcctcca gtactgggga     1620

tttgccaaaa gcaaaaaccc gggcagctga cttgttggtg aatcccctgg atccgcggaa     1680

tgcagataaa attagagtaa aaattgctga cctgggaaat gcttgttggg tgcataaaca     1740

cttcacggaa gacatccaga cgcgtcagta ccgctccata gaggttttaa taggagcggg     1800

gtacagcacc cctgcggaca tctggagcac ggcgtgtatg gcatttgagc tggcaacggg     1860

agattatttg tttgaaccac attctgggga agactattcc agagacgaag accacatagc     1920

ccacatcata gagctgctag gcagtattcc aaggcacttt gctctatctg gaaaatattc     1980

tcgggaattc ttcaatcgca gaggagaact gcgacacatc accaagctga agccctggag     2040

cctctttgat gtacttgtgg aaaagtatgg ctggccccat gaagatgctg cacagtttac     2100

agatttcctg atcccgatgt tagaaatggt tccagaaaaa cgagcctcag ctggcgaatg     2160

ccttcggcat ccttggttga attcttagca aattctacca atattgcatt ctgagctagc     2220

aaatgttccc agtacattgg acctaaacgg tgactctcat tctttaacag gattacaagt     2280

gagctggctt catcctcaga cctttatttt gctttgaggt actgttgttt gacattttgc     2340

tttttgtgca ctgtgatcct ggggaagggt agtcttttgt cttcagctaa gtagtttact     2400

gaccattttc ttctggaaac aataacatgt ctctaagcat tgtttcttgt gttgtgtgac     2460

attcaaatgt catttttttg aatgaaaaat actttcccct ttgtgttttg gcaggttttg     2520

taactattta tgaagaaata ttttagctga gtactatata atttacaatc ttaagaaatt     2580

atcaagttgg aaccaagaaa tagcaaggaa atgtacaatt ttatcttctg gcaaagggac     2640

atcattcctg tattatagtg tatgtaaatg caccctgtaa atgttacttt ccattaaata     2700

tgggaggggg actcaaattt cagaaaagct accaagtctt gagtgctttg tagcctatgt     2760

tgcatgtagc ggactttaac tgctccaagg agttgtgcaa acttttcatt ccataacagt     2820

cttttcacat tggattttaa acaaagtggc tctgggttat aagatgtcat tctctatatg     2880

gcactttaaa ggaagaaaag atatgtttct cattctaaaa tatgcattat aatttagcag     2940

tcccatttgt gattttgcat atttttaaaa gtacttttaa agaagagcaa tttcccttta     3000

aaaatgtgat ggctcagtac catgtcatgt tgcctcctct gggcgctgta agttaagctc     3060

tacatagatt aaattggaga aacgtgttaa ttgtgtggaa tgaaaaaata catatatttt     3120

tggaaaagca tgatcatgct tgtctagaac acaaggtatg gtatatacaa tttgcagtgc     3180

agtgggcaga atacttctca cagctcaaag ataacagtga tcacattcat tccataggta     3240

gctttacgtg tggctacaac aaattttact agctttttca ttgtctttcc atgaaacgaa     3300

gttgagaaaa tgattttccc tttgcaggtt gcacacagtt ttgtttatgc atttccttaa     3360

aattaattgt agactccagg atacaaacca tagtaggcaa tacaatttta gaatgtaata     3420

tatagaggta tatttagcct cttttagaag tcagtggatt gaatgtcttt ttattttaaa     3480

ttttacattc attaaggtgc ctcgtttttg actttgtcca ttaacattta tccatatgcc     3540

tttgcaataa ctagattgtg aaaagctaac aagtgttgta acaataatcc attgtttgag     3600

gtgcttgcag ttgtcttaaa aattaaagtg ttttggtttt tttttttcca                3650


<210> 2312
<211> 1710
<212> DNA
<213> Homo sapiens

<400> 2312
cgcgccgctt ccggtctgca gccttgtagt ggggctggag cagagcctgc cgcgaacccc       60

cggagcccac gatccctcgt gccatccctc gaatccacca gcacgagcgt cccacccgcg      120

cctgggacca tggccactga ctcatgggcc ctggcggtgg acgagcagga agctgcggct      180

gagtcgagga cagagctgcc cagtccttac tcaacaagct gatcagaagc aaccttgttg      240

ataacacaaa ccaagtggaa gtcctgcagc gggatccaaa ctcccctctg tactcggtga      300

agtcttttga agagcttcgg ctgaaaccac agcttctcca aggagtctat gccatgggtt      360

tcaatcgtcc atccaagata caagagaacg cattgccact gatgcttgct gagcccccac      420

agaacttaat tgcccaatct cagtctggta ctggtaaaac agctgccttc gtgctggcca      480

tgcttagcca agtagaacct gcaaacaaat acccccagtg tctatgtctc tccccaacgt      540

atgagctcgc cctccaaaca ggaaaagtga ttgaacaaat gggcaaattt taccctgaac      600

tgaagctagc ttatgctgtt cgaggcaata aattggaaag aggccagaag atcagtgagc      660

agattgtcat tggcacccct gggactgtgc tggactggtg ctccaagctc aagttcattg      720

atcccaagaa aatcaaggtg tttgttctgg atgaggctga tgtcatgata gccactcagg      780

gccaccaaga tcagagcatc cgcatccaga ggatgctgcc caggaactgc cagatgctgc      840

ttttctccgc cacctttgaa gactctgtgt ggaagtttgc ccagaaagtg gtcccagacc      900

caaacgttat caaactgaag cgtgaggaag agaccctgga caccatcaag cagtactatg      960

tcctgtgcag cagcagagac gagaagttcc aggccttgtg taacctctac ggggccatca     1020

ccattgctca agccatgatc ttctgccata ctcgcaaaac agctagttgg ctggcagcag     1080

agctctcaaa agaaggccac caggtggctc tgctgagtgg ggagatgatg gtggaacaga     1140

gggctgcagt gattgagcgc ttccgagagg gcaaagagaa ggttttggtg accaccaacg     1200

tgtgtgcccg cggcattgat gttgaacaag tgtctgtcgt catcaacttt gatcttcccg     1260

tggacaagga cgggaatcct gacaatgaga cctacctgca ccggatcggg cgcacgggcc     1320

gctttggcaa gaggggcctg gcagtgaaca tggtggacag caagcacagc atgaacatcc     1380

tgaacagaat ccaggagcat tttaataaga agatagaaag attggacaca gatgatttgg     1440

acgagattga gaaaatagcc aactgagaag ctccaccagc cactgatgcc agccctggca     1500

ctgcccctgc acaggagaca agtgcgttca gggcacaggc cccgacatca ccccaaggac     1560

aacggcacaa gtagagagaa actacctacc tcacttcaaa ttatgtttgg acttgacaaa     1620

aatgtatgca aatgatgggg gatggtagaa aaaaattatt tacacaacct tggaagatta     1680

ggcatgaata cacagagatt taccttttgg                                      1710


<210> 2313
<211> 5119
<212> DNA
<213> Homo sapiens

<400> 2313
gaactcaagg cctgcttgat acgtccgcca ttttgggcgc ttcgctgatg gtgtcggtga       60

gcgcgtttcc cgcctgagcg caactagcgg cgggtcgtgg gcacctccag gagagcttgt      120

ttcatatcca tatcccactg tattcctgct aatctgctaa tgcagtaaat tggaggaaaa      180

ctgttaccag gataacctgt aatgggcaag gagccacaaa gaagaaaaca tttcttttaa      240

tttttaaact tggtttgaaa gaccagcatg ttttggaaat ttgatcttca ctcatcatcc      300

cacatagaca cacttctaga aagagaagat gtaacactga aggagttaat ggatgaggaa      360

gatgttttac aggaatgtaa agctcagaac cgcaaactta tagagtttct gttaaaagca      420

gaatgtctcg aagatttagt ctcattcatt atagaagaac cacctcaaga catggatgaa      480

aagatcagat acaagtatcc aaatatatct tgtgagttgc tcacttctga tgtctcccag      540

atgaatgata gactgggaga agatgaatcc ttgctaatga aattatatag cttcctccta      600

aacgattccc ctttgaatcc actacttgcc agtttcttca gcaaggtgct aagtattctt      660

atcagcagaa aaccagaaca gattgtggat ttcttaaaga agaagcatga ttttgtagac      720

cttattataa agcacatagg aacttctgct atcatggatt tgttgctcag gctcctgacg      780

tgtatcgaac ctccacagcc caggcaagat gtgctgaatt ggttaaatga ggagaaaatt      840

atccagaggc ttgtggaaat agttcatcca tcgcaagaag aagatcgaca ttcaaatgca      900

tcacaatcac tttgtgaaat tgttcgcctg agcagagacc agatgttaca aattcagaac      960

agtacagagc ccgaccccct gcttgccact ctagaaaagc aagaaattat agagcagctt     1020

ctatcaaata ttttccacaa ggagaaaaat gagtcagcca tagtcagtgc aatccagata     1080

ttgctgactt tacttgagac acgacgacca acatttgaag gccatataga gatctgccca     1140

ccaggcatga gccattcagc ttgttcagta aacaagagtg ttctagaagc catcagagga     1200

agacttggat cttttcatga actcctgctg gagccaccca agaaaagtgt gatgaagacc     1260

acatggggtg tgctggatcc tcctgtgggg aatacccggt tgaatgtcat taggttgata     1320

tccagcctgc ttcaaaccaa taccagcagt ataaatgggg accttatgga gctgaatagc     1380

attggagtca tattgaacat gttcttcaag tatacatgga ataacttttt gcatacacaa     1440

gtggaaattt gtattgcact gattcttgca agtccttttg aaaacacaga aaatgccaca     1500

attaccgatc aagactccac tggtgataat ttgttattaa aacatctttt ccaaaaatgt     1560

caattaatag aacgaatact tgaagcctgg gaaatgaatg agaagaaaca ggctgaggga     1620

ggaagacggc atggttacat gggacaccta acgaggatag ctaactgtat cgtgcacagc     1680

actgacaagg gccccaacag tgcattagtg cagcagctta tcaaagatct tcccgacgaa     1740

gtcagggaac gatgggagac gttctgcaca agctccttag gagaaactaa caagaggaac     1800

acggtagatc tagttacaac ctgccatatt cattcatcca gtgatgatga aattgacttt     1860

aaagaaacgg gtttctcaca ggattcttct ttgcagcaag ccttttctga ttatcagatg     1920

caacaaatga cgtccaattt tattgaccag tttggcttca acgatgagaa gtttgcagat     1980

caagatgaca ttggcaatgt ttcttttgat cgagtatcag acatcaactt tactctcaat     2040

acaaatgaaa gtggaaatat tgccttgttt gaagcatgtt gtaaggaaag aatacaacag     2100

tttgatgatg gtggctctga tgaggaagat atatgggagg aaaagcacat cgcattcaca     2160

ccagaatccc aaagacgatc cagctcgggg agtacagaca gtgaggaaag tacagactct     2220

gaagaagaag atggagcaaa gcaagacttg tttgaaccca gcagtgccaa cacggaggat     2280

aaaatggagg tggacctgag tgaaccaccc aactggtcag ctaactttga tgtcccaatg     2340

gaaacaaccc acggtgctcc attggattct gtgggatctg atgtctggag cacagaggag     2400

ccgatgccaa ctaaagagac gggctgggct tctttttcag agttcacgtc ttccctgagc     2460

acaaaagatt ctttaaggag taattctcca gtggaaatgg aaaccagcac tgaacccatg     2520

gaccctctga ctcccagtgc ggctgccctg gcagtgcagc cagaagcggc aggcagtgtg     2580

gccatggaag ccagctctga cggagaggag gatgcagaaa gtacagacaa ggtaactgag     2640

acagtgatga atggcggcat gaaggaaacg ctcagcctca ctgtagatgc caagacagag     2700

actgcggtct tcaaaaggtt attgggagga tgcagtgagg aagggaaact gtctacctct     2760

caagatgctg cttgtaaaga cgcagaggag tgtcccgaga ctgcagaggc gaagtgcgcg     2820

gcgcccaggc ctcccagcag cagtcccgag cagaggactg gccaaccaag cgcaccaggt     2880

gacacttcag tgaatggccc tgtatgacgg gtgacgtctg ctgctgctga ctgaggactg     2940

cagaccgcca ccactcaggg gctctggagg ggtcagctgg agcccaccaa gctgtcactg     3000

ctgcactcac tctgcaaggg atcaggacca gcaaccttta tattctagat tctaagacat     3060

tgtacagaga aattcagaag tgtaaaaata ttgcacattg acaaatacca agaatttttg     3120

cgtatgttta tattgtattg ttctaaataa tgggtagcct gtgaaataag atcttgccac     3180

ccatgtaata atagtagtaa tactatagtt aaaatggctg taagaatagt tttataaaag     3240

tgaatacaca gatctattgt atttgaaaca taactttgac aattattagt gtgaccaaag     3300

tattaggcgg ttttcataca tttttcacct tgtacaaaat tatgaattca tttttcctcc     3360

aggccgacaa ggagttgtag aatgaaaatg ccctctaagt gttattttgg ttgttctaac     3420

ttacaaaagt gattttgaat aagaaatatt tggtgttctt tttataacca gtttttgatt     3480

ggtaattgtt ttctgtattg tttaaaacgg atcaaaaatg taagtctatt ggtagagatt     3540

aagtaaagta tttattgcta catcatagtt gataaattga tgttatcgta aagccatatg     3600

ttctgttcaa gtcttgtttg cttgaaatga ttattcctac aagtgaaaca ctagactatt     3660

tggagtgtat atggcttgtg ttttgggatt tttttttttt ttttttggct tttgtttttg     3720

tttgtttttt tgtttcattt ggtagttcat ctgcctttta acccattcac caaaatttac     3780

cttgttaaca agcatcacca atgaacattt cagagcaatc tgcatattta acagacctaa     3840

aataaatcct attaggcaag tcagttgaaa atgctcgtgc tgctaatgga attagagtgc     3900

gttcatttta caggctagta ttttaaaagt agaaatcaaa atctggcacc gaagcatgct     3960

aattgtttac tgtaccttgt gaggttttca ctcataaatt taaaccagtg tattttttta     4020

gaactggttt gtgtatatat atagtgatta tggatactaa ttcaatgtaa tttataattt     4080

tctatgtcaa tacaaaaata catcacagcc ttctcaaaca gctcaagcaa tatattgtat     4140

attgccatat cgtctggtga aagggttaaa ttacttcacc tcttgcactt ttagatgcaa     4200

atcagttttt catttctgta atagaaaatt attcacgtat ttttacatca tttgtttttc     4260

ctgaccagta tttaaaacca aaaggatatt ctgaaaaatg gccaacaatt tttttagaag     4320

tagcatccca agcagcgtgc ctaaacatta cattgcatat ggaaataaaa gaatcaaacg     4380

tctaatgcct tattatttct gatttccttt ttcattttaa gtggtgtgga gattccagca     4440

ctcccaggac agtggagtca gcagtaagcc ctgggacagg tggcaagggt gggtcccttg     4500

acctttgcac gcctcctcag gaaccccctt tcccgggtga gcccctctct gaagagactg     4560

tccttgggcc tcctctggaa gcagcacccc cagaggacag ggctcctcct gcttgcctca     4620

gggctgcctg acttgaatgg cgttggacct cggggattac tggtagataa tatgctctgg     4680

tctcgcctgg tggtgagttt tgccagccat ggccagggtt tggctccact ggtggcacac     4740

gtggcctccg tggtatggac ctggtggctt ctccatccca ctgtggcctc tgtggtatgg     4800

acctggtggc ttctccatcc tacccaaggt aacagtgtct tgcttcatcc cactgactgc     4860

tgggagagag cctctgggac ttttctttgg ggcatcattt tgttttgtct ttcgtagcag     4920

ggaaaggata tgacaatggg gaggacagtt cttttggagg ttggaggggc caagccaagg     4980

acaggagcaa gtgtgccctc attttgtttc tacttttaat ttctgtgtgt tggccatact     5040

gaattatgag actaacagat gtctacaata caatacctgt attcaaaata acaaaaataa     5100

agcctgattc tttgtttct                                                  5119


<210> 2314
<211> 5093
<212> DNA
<213> Homo sapiens

<400> 2314
gcttgatacg tccgccattt tgggcgcttc gctgatggtg tcggtgagcg cgtttcccgc       60

ctgagcgcaa ctagcggcgg gtcgtgggca cctccaggag agcttgtttc atatccatat      120

cccactgtat tcctgctaat ctgctaatgc agtaaattgg aggaaaactg ttaccaggat      180

aacctgtaat gggcaaggag ccacaaagaa gaaaacattt cttttaattt ttaaacttgg      240

tttgaaagac cagcatgttt tggaaatttg atcttcactc atcatcccac atagacacac      300

ttctagaaag agaagatgta acactgaagg agttaatgga tgaggaagat gttttacagg      360

aatgtaaagc tcagaaccgc aaacttatag agtttctgtt aaaagcagaa tgtctcgaag      420

atttagtctc attcattata gaagaaccac ctcaagacat ggatgaaaag atcagataca      480

agtatccaaa tatatcttgt gagttgctca cttctgatgt ctcccagatg aatgatagac      540

tgggagaaga tgaatccttg ctaatgaaat tatatagctt cctcctaaac gattcccctt      600

tgaatccact acttgccagt ttcttcagca aggtgctaag tattcttatc agcagaaaac      660

cagaacagat tgtggatttc ttaaagaaga agcatgattt tgtagacctt attataaagc      720

acataggaac ttctgctatc atggatttgt tgctcaggct cctgacgtgt atcgaacctc      780

cacagcccag gcaagatgtg ctgaattggt taaatgagga gaaaattatc cagaggcttg      840

tggaaatagt tcatccatcg caagaagaag atcgacattc aaatgcatca caatcacttt      900

gtgaaattgt tcgcctgagc agagaccaga tgttacaaat tcagaacagt acagagcccg      960

accccctgct tgccactcta gaaaagcaag aaattataga gcagcttcta tcaaatattt     1020

tccacaagga gaaaaatgag tcagccatag tcagtgcaat ccagatattg ctgactttac     1080

ttgagacacg acgaccaaca tttgaaggcc atatagagat ctgcccacca ggcatgagcc     1140

attcagcttg ttcagtaaac aagagtgttc tagaagccat cagaggaaga cttggatctt     1200

ttcatgaact cctgctggag ccacccaaga aaagtgtgat gaagaccaca tggggtgtgc     1260

tggatcctcc tgtggggaat acccggttga atgtcattag gttgatatcc agcctgcttc     1320

aaaccaatac cagcagtata aatggggacc ttatggagct gaatagcatt ggagtcatat     1380

tgaacatgtt cttcaagtat acatggaata actttttgca tacacaagtg gaaatttgta     1440

ttgcactgat tcttgcaagt ccttttgaaa acacagaaaa tgccacaatt accgatcaag     1500

actccactgg tgataatttg ttattaaaac atcttttcca aaaatgtcaa ttaatagaac     1560

gaatacttga agcctgggaa atgaatgaga agaaacaggc tgagggagga agacggcatg     1620

gttacatggg acacctaacg aggatagcta actgtatcgt gcacagcact gacaagggcc     1680

ccaacagtgc attagtgcag cagcttatca aagatcttcc cgacgaagtc agggaacgat     1740

gggagacgtt ctgcacaagc tccttaggag aaactaacaa gaggaacacg gtagatctag     1800

ttacaacctg ccatattcat tcatccagtg atgatgaaat tgactttaaa gaaacgggtt     1860

tctcacagga ttcttctttg cagcaagcct tttctgatta tcagatgcaa caaatgacgt     1920

ccaattttat tgaccagttt ggcttcaacg atgagaagtt tgcagatcaa gatgacattg     1980

gcaatgtttc ttttgatcga gtatcagaca tcaactttac tctcaataca aatgaaagtg     2040

gaaatattgc cttgtttgaa gcatgttgta aggaaagaat acaacagttt gatgatggtg     2100

gctctgatga ggaagatata tgggaggaaa agcacatcgc attcacacca gaatcccaaa     2160

gacgatccag ctcggggagt acagacagtg aggaaagtac agactctgaa gaagaagatg     2220

gagcaaagca agacttgttt gaacccagca gtgccaacac ggaggataaa atggaggtgg     2280

acctgagtga accacccaac tggtcagcta actttgatgt cccaatggaa acaacccacg     2340

gtgctccatt ggattctgtg ggatctgatg tctggagcac agaggagccg atgccaacta     2400

aagagacggg ctgggcttct ttttcagagt tcacgtcttc cctgagcaca aaagattctt     2460

taaggagtaa ttctccagtg gaaatggaaa ccagcactga acccatggac cctctgactc     2520

ccagtgcggc tgccctggca gtgcagccag aagcggcagg cagtgtggcc atggaagcca     2580

gctctgacgg agaggaggat gcagaaagta cagacaaggt aactgagaca gtgatgaatg     2640

gcggcatgaa ggaaacgctc agcctcactg tagatgccaa gacagagact gcggtcttca     2700

aaagtgagga agggaaactg tctacctctc aagatgctgc ttgtaaagac gcagaggagt     2760

gtcccgagac tgcagaggcg aagtgcgcgg cgcccaggcc tcccagcagc agtcccgagc     2820

agaggactgg ccaaccaagc gcaccaggtg acacttcagt gaatggccct gtatgacggg     2880

tgacgtctgc tgctgctgac tgaggactgc agaccgccac cactcagggg ctctggaggg     2940

gtcagctgga gcccaccaag ctgtcactgc tgcactcact ctgcaaggga tcaggaccag     3000

caacctttat attctagatt ctaagacatt gtacagagaa attcagaagt gtaaaaatat     3060

tgcacattga caaataccaa gaatttttgc gtatgtttat attgtattgt tctaaataat     3120

gggtagcctg tgaaataaga tcttgccacc catgtaataa tagtagtaat actatagtta     3180

aaatggctgt aagaatagtt ttataaaagt gaatacacag atctattgta tttgaaacat     3240

aactttgaca attattagtg tgaccaaagt attaggcggt tttcatacat ttttcacctt     3300

gtacaaaatt atgaattcat ttttcctcca ggccgacaag gagttgtaga atgaaaatgc     3360

cctctaagtg ttattttggt tgttctaact tacaaaagtg attttgaata agaaatattt     3420

ggtgttcttt ttataaccag tttttgattg gtaattgttt tctgtattgt ttaaaacgga     3480

tcaaaaatgt aagtctattg gtagagatta agtaaagtat ttattgctac atcatagttg     3540

ataaattgat gttatcgtaa agccatatgt tctgttcaag tcttgtttgc ttgaaatgat     3600

tattcctaca agtgaaacac tagactattt ggagtgtata tggcttgtgt tttgggattt     3660

tttttttttt tttttggctt ttgtttttgt ttgttttttt gtttcatttg gtagttcatc     3720

tgccttttaa cccattcacc aaaatttacc ttgttaacaa gcatcaccaa tgaacatttc     3780

agagcaatct gcatatttaa cagacctaaa ataaatccta ttaggcaagt cagttgaaaa     3840

tgctcgtgct gctaatggaa ttagagtgcg ttcattttac aggctagtat tttaaaagta     3900

gaaatcaaaa tctggcaccg aagcatgcta attgtttact gtaccttgtg aggttttcac     3960

tcataaattt aaaccagtgt atttttttag aactggtttg tgtatatata tagtgattat     4020

ggatactaat tcaatgtaat ttataatttt ctatgtcaat acaaaaatac atcacagcct     4080

tctcaaacag ctcaagcaat atattgtata ttgccatatc gtctggtgaa agggttaaat     4140

tacttcacct cttgcacttt tagatgcaaa tcagtttttc atttctgtaa tagaaaatta     4200

ttcacgtatt tttacatcat ttgtttttcc tgaccagtat ttaaaaccaa aaggatattc     4260

tgaaaaatgg ccaacaattt ttttagaagt agcatcccaa gcagcgtgcc taaacattac     4320

attgcatatg gaaataaaag aatcaaacgt ctaatgcctt attatttctg atttcctttt     4380

tcattttaag tggtgtggag attccagcac tcccaggaca gtggagtcag cagtaagccc     4440

tgggacaggt ggcaagggtg ggtcccttga cctttgcacg cctcctcagg aacccccttt     4500

cccgggtgag cccctctctg aagagactgt ccttgggcct cctctggaag cagcaccccc     4560

agaggacagg gctcctcctg cttgcctcag ggctgcctga cttgaatggc gttggacctc     4620

ggggattact ggtagataat atgctctggt ctcgcctggt ggtgagtttt gccagccatg     4680

gccagggttt ggctccactg gtggcacacg tggcctccgt ggtatggacc tggtggcttc     4740

tccatcccac tgtggcctct gtggtatgga cctggtggct tctccatcct acccaaggta     4800

acagtgtctt gcttcatccc actgactgct gggagagagc ctctgggact tttctttggg     4860

gcatcatttt gttttgtctt tcgtagcagg gaaaggatat gacaatgggg aggacagttc     4920

ttttggaggt tggaggggcc aagccaagga caggagcaag tgtgccctca ttttgtttct     4980

acttttaatt tctgtgtgtt ggccatactg aattatgaga ctaacagatg tctacaatac     5040

aatacctgta ttcaaaataa caaaaataaa gcctgattct ttgtttctag aaa            5093


<210> 2315
<211> 5069
<212> DNA
<213> Homo sapiens

<400> 2315
gtcggtgagc gcgtttcccg cctgagcgca actagcggcg ggtcgtgggc acctccagga       60

gagcttgttt catatccata tcccactgta ttcctgctaa tctgctaatg cagtaaattg      120

gaggaaaact gttaccagga taacctgtaa tgggcaagga gccacaaaga agaaaacatt      180

tcttttaatt tttaaacttg gtttgaaaga ccagcatgtt ttggaaattt gatcttcact      240

catcatccca catagacaca cttctagaaa gagaagatgt aacactgaag gagttaatgg      300

atgaggaaga tgttttacag gaatgtaaag ctcagaaccg caaacttata gagtttctgt      360

taaaagcaga atgtctcgaa gatttagtct cattcattat agaagaacca cctcaagaca      420

tggatgaaaa gatcagatac aagtatccaa atatatcttg tgagttgctc acttctgatg      480

tctcccagat gaatgataga ctgggagaag atgaatcctt gctaatgaaa ttatatagct      540

tcctcctaaa cgattcccct ttgaatccac tacttgccag tttcttcagc aaggtgctaa      600

gtattcttat cagcagaaaa ccagaacaga ttgtggattt cttaaagaag aagcatgatt      660

ttgtagacct tattataaag cacataggaa cttctgctat catggatttg ttgctcaggc      720

tcctgacgtg tatcgaacct ccacagccca ggcaagatgt gctgaattgg ttaaatgagg      780

agaaaattat ccagaggctt gtggaaatag ttcatccatc gcaagaagaa gatcgacatt      840

caaatgcatc acaatcactt tgtgaaattg ttcgcctgag cagagaccag atgttacaaa      900

ttcagaacag tacagagccc gaccccctgc ttgccactct agaaaagcaa gaaattatag      960

agcagcttct atcaaatatt ttccacaagg agaaaaatga gtcagccata gtcagtgcaa     1020

tccagatatt gctgacttta cttgagacac gacgaccaac atttgaaggc catatagaga     1080

tctgcccacc aggcatgagc cattcagctt gttcagtaaa caagagtgtt ctagaagcca     1140

tcagaggaag acttggatct tttcatgaac tcctgctgga gccacccaag aaaagtgtga     1200

tgaagaccac atggggtgtg ctggatcctc ctgtggggaa tacccggttg aatgtcatta     1260

ggttgatatc cagcctgctt caaaccaata ccagcagtat aaatggggac cttatggagc     1320

tgaatagcat tggagtcata ttgaacatgt tcttcaagta tacatggaat aactttttgc     1380

atacacaagt ggaaatttgt attgcactga ttcttgcaag tccttttgaa aacacagaaa     1440

atgccacaat taccgatcaa gactccactg gtgataattt gttattaaaa catcttttcc     1500

aaaaatgtca attaatagaa cgaatacttg aagcctggga aatgaatgag aagaaacagg     1560

ctgagggagg aagacggcat ggttacatgg gacacctaac gaggatagct aactgtatcg     1620

tgcacagcac tgacaagggc cccaacagtg cattagtgca gcagcttatc aaagatcttc     1680

ccgacgaagt cagggaacga tgggagacgt tctgcacaag ctccttagga gaaactaaca     1740

agaggaacac ggtagatcta gttacaacct gccatattca ttcatccagt gatgatgaaa     1800

ttgactttaa agaaacgggt ttctcacagg attcttcttt gcagcaagcc ttttctgatt     1860

atcagatgca acaaatgacg tccaatttta ttgaccagtt tggcttcaac gatgagaagt     1920

ttgcagatca agatgacatt ggcaatgttt cttttgatcg agtatcagac atcaacttta     1980

ctctcaatac aaatgaaagt ggaaatattg ccttgtttga agcatgttgt aaggaaagaa     2040

tacaacagtt tgatgatggt ggctctgatg aggaagatat atgggaggaa aagcacatcg     2100

cattcacacc agaatcccaa agacgatcca gctcggggag tacagacagt gaggaaagta     2160

cagactctga agaagaagat ggagcaaagc aagacttgtt tgaacccagc agtgccaaca     2220

cggaggataa aatggaggtg gacctgagtg aaccacccaa ctggtcagct aactttgatg     2280

tcccaatgga aacaacccac ggtgctccat tggattctgt gggatctgat gtctggagca     2340

cagaggagcc gatgccaact aaagagacgg gctgggcttc tttttcagag ttcacgtctt     2400

ccctgagcac aaaagattct ttaaggagta attctccagt ggaaatggaa accagcactg     2460

aacccatgga ccctctgact cccagtgcgg ctgccctggc agtgcagcca gaagcggcag     2520

gcagtgtggc catggaagcc agctctgacg gagaggagga tgcagaaagt acagacaagg     2580

taactgagac agtgatgaat ggcggcatga aggaaacgct cagcctcact gtagatgcca     2640

agacagagac tgcggtcttc aaaagagtgt tgaaatccta tcgtgaggaa gggaaactgt     2700

ctacctctca agatgctgct tgtaaagacg cagaggagtg tcccgagact gcagaggcga     2760

agtgcgcggc gcccaggcct cccagcagca gtcccgagca gaggactggc caaccaagcg     2820

caccaggtga cacttcagtg aatggccctg tatgacgggt gacgtctgct gctgctgact     2880

gaggactgca gaccgccacc actcaggggc tctggagggg tcagctggag cccaccaagc     2940

tgtcactgct gcactcactc tgcaagggat caggaccagc aacctttata ttctagattc     3000

taagacattg tacagagaaa ttcagaagtg taaaaatatt gcacattgac aaataccaag     3060

aatttttgcg tatgtttata ttgtattgtt ctaaataatg ggtagcctgt gaaataagat     3120

cttgccaccc atgtaataat agtagtaata ctatagttaa aatggctgta agaatagttt     3180

tataaaagtg aatacacaga tctattgtat ttgaaacata actttgacaa ttattagtgt     3240

gaccaaagta ttaggcggtt ttcatacatt tttcaccttg tacaaaatta tgaattcatt     3300

tttcctccag gccgacaagg agttgtagaa tgaaaatgcc ctctaagtgt tattttggtt     3360

gttctaactt acaaaagtga ttttgaataa gaaatatttg gtgttctttt tataaccagt     3420

ttttgattgg taattgtttt ctgtattgtt taaaacggat caaaaatgta agtctattgg     3480

tagagattaa gtaaagtatt tattgctaca tcatagttga taaattgatg ttatcgtaaa     3540

gccatatgtt ctgttcaagt cttgtttgct tgaaatgatt attcctacaa gtgaaacact     3600

agactatttg gagtgtatat ggcttgtgtt ttgggatttt tttttttttt ttttggcttt     3660

tgtttttgtt tgtttttttg tttcatttgg tagttcatct gccttttaac ccattcacca     3720

aaatttacct tgttaacaag catcaccaat gaacatttca gagcaatctg catatttaac     3780

agacctaaaa taaatcctat taggcaagtc agttgaaaat gctcgtgctg ctaatggaat     3840

tagagtgcgt tcattttaca ggctagtatt ttaaaagtag aaatcaaaat ctggcaccga     3900

agcatgctaa ttgtttactg taccttgtga ggttttcact cataaattta aaccagtgta     3960

tttttttaga actggtttgt gtatatatat agtgattatg gatactaatt caatgtaatt     4020

tataattttc tatgtcaata caaaaataca tcacagcctt ctcaaacagc tcaagcaata     4080

tattgtatat tgccatatcg tctggtgaaa gggttaaatt acttcacctc ttgcactttt     4140

agatgcaaat cagtttttca tttctgtaat agaaaattat tcacgtattt ttacatcatt     4200

tgtttttcct gaccagtatt taaaaccaaa aggatattct gaaaaatggc caacaatttt     4260

tttagaagta gcatcccaag cagcgtgcct aaacattaca ttgcatatgg aaataaaaga     4320

atcaaacgtc taatgcctta ttatttctga tttccttttt cattttaagt ggtgtggaga     4380

ttccagcact cccaggacag tggagtcagc agtaagccct gggacaggtg gcaagggtgg     4440

gtcccttgac ctttgcacgc ctcctcagga accccctttc ccgggtgagc ccctctctga     4500

agagactgtc cttgggcctc ctctggaagc agcaccccca gaggacaggg ctcctcctgc     4560

ttgcctcagg gctgcctgac ttgaatggcg ttggacctcg gggattactg gtagataata     4620

tgctctggtc tcgcctggtg gtgagttttg ccagccatgg ccagggtttg gctccactgg     4680

tggcacacgt ggcctccgtg gtatggacct ggtggcttct ccatcccact gtggcctctg     4740

tggtatggac ctggtggctt ctccatccta cccaaggtaa cagtgtcttg cttcatccca     4800

ctgactgctg ggagagagcc tctgggactt ttctttgggg catcattttg ttttgtcttt     4860

cgtagcaggg aaaggatatg acaatgggga ggacagttct tttggaggtt ggaggggcca     4920

agccaaggac aggagcaagt gtgccctcat tttgtttcta cttttaattt ctgtgtgttg     4980

gccatactga attatgagac taacagatgt ctacaataca atacctgtat tcaaaataac     5040

aaaaataaag cctgattctt tgtttctag                                       5069


<210> 2316
<211> 1395
<212> DNA
<213> Homo sapiens

<400> 2316
acttccttcg tctgggtggt tgccccagcg acacgttggg ccgaagagcg gtgttgggta       60

cccgagagac ccggcggtgg ggaagtcact tcctcccgaa gacgctgttt cctagcaacc      120

gccctccgcc tctgttatta gcccctcctc ctcgctcggt ccaggaccgg ctctgcgggc      180

gccgccaggc ccagaccaag ctactatcag aagttgaatt ctaataatta gctattttat      240

aaaggtaacg agaaaaaata cactatgtct gatgaagttt ttagcaccac tttggcatat      300

acaaagagtc caaaagttac caaaagaact actttccagg atgagctaat aagagcaatt      360

acagctcgct cagccagaca aaggagttct gaatactcag atgactttga cagtgatgag      420

attgtttctt taggtgattt ttctgacact tcagcagatg aaaattcagt taataaaaaa      480

atgaatgact ttcatatatc agatgatgaa gaaaagaatc cttcaaaact attgtttttg      540

aaaaccaata aatcaaacgg taacataacc aaagatgagc cagtgtgtgc catcaaaaat      600

gaagaggaaa tggcacctga tgggtgtgaa gacattgttg taaaatcttt ctctgaatct      660

caaaataagg atgaggaatt tgaaaaagac aaaataaaaa tgaaacctaa acccagaatt      720

ctttcaatta aaagcacatc ttcagcagaa aacaacagcc ttgacacaga tgatcacttt      780

aaaccatcac ctcggccaag gagtatgttg aaaaagaaaa gtcacatgga ggagaaggat      840

ggactagaag ataaagaaac tgccctcagt gaagaattgg agttacattc tgcaccttct      900

tcccttccaa cgccgaatgg catacaatta gaagctgaga aaaaagcatt ctctgaaaac      960

cttgatcctg aggattcatg cttaacaagt ctagcatcat catcacttaa acaaattctt     1020

ggagattctt tttcaccagg atctgaggga aacgcatctg gaaaagatcc aaatgaagaa     1080

atcactgaaa accataattc cttgaaatca gatgaaaata aagagaattc attttcagca     1140

gaccatgtga ctactgcagt tgagaaatcc aaggaaagtc aagtgactgc tgatgacctt     1200

gaagaagaaa aggcaaaagc ggaactgatt atggatgatg acagaacagt tgatccacta     1260

ctatctaaat ctcagagtat cttaatatct accagtgcaa cagcatcttc aaagaaaaca     1320

attgaagata gaaatataaa gaataaaaag tcaacaaata atagagcatc cagtgcatct     1380

gccagcaaag ctagt                                                      1395


<210> 2317
<211> 1644
<212> DNA
<213> Homo sapiens

<400> 2317
agcctacacc gactctggag gaagactgga gcctttgcgg cggcgctgcc cctcccctgg       60

tccccgcgag ctcggagggc ccggctggtg ctgcgggggc cccgggaggt acggacctgg      120

gaggcgaggc tcgtccggcg ctaggatcgg cctccgcctc cgggccgctt taggttgaaa      180

actaagcatg gggaagagct gcaaggtggt cgtgtgtggc caggcgtctg tgggcaaaac      240

ttcaatcctg gagcagcttc tgtatgggaa ccatgtagtg ggttcggaga tgatcgagac      300

gcaggaggac atctacgtgg gctccattga gacagaccgg ggggtgcgag agcaggtgcg      360

tttctatgac acccgggggc tccgagatgg ggccgaactg ccccgacact gcttctcttg      420

cactgatggc tacgtcctgg tctatagcac agatagcaga gagtcttttc agcgtgtgga      480

gctgctcaag aaggagattg acaaatccaa ggacaagaag gaggtcacca tcgtggtcct      540

tggcaacaag tgtgacttac aggagcagcg gcgtgtagac ccagatgtgg ctcagcactg      600

ggccaagtca gagaaggtga agctgtggga ggtgtcagtg gcggaccggc gctccctcct      660

ggagcccttt gtctacttgg ccagcaagat gacgcaaccc cagagcaagt ctgccttccc      720

cctcagccgg aagaacaagg gcagcggctc cttggatggc tgaagagctg ccgttcctct      780

ttcacgatcc cagccccatt tcagtgtctg gggctctggt agatgtgttg agggcaaagt      840

agaggacaag ctgtctttcc cagtcagcca gggagctccc cgccaggcca cgccccagcc      900

actttgctcc ctctcacctc tgggaagtgc aaatactctt ggttgacatc cccttcctca      960

gccctcccag cctactcccc atcccagctt ttagaggatc tgctccactg tctcctgggg     1020

cagttgtggg tcactgtccc ttccagctgc cccagacagg aagcagagtc accacgcagc     1080

agtgtccctt cttgggtctg agttcctatt ataggtaggg gccccaccct ctgggcttcc     1140

catcagcgac acacacacac ttatggcacc agcctggact ccagaaaaag ggtgtccagg     1200

tattgtgtgt atgcatttag ttgtgcacac acaaatatgc tcctatactg gcattaggcg     1260

tctcctcatc cctcaccctg acctttctcc tgtccttttc ttggctggaa gaagttggcc     1320

tcctgggagt gtagttttct gttttaaatc ccccacccct ggctgggctc agtggctcac     1380

ccctgtaatc ccagcacttt gggaggccaa ggcgggtcga ttacttgagg tcaggagttc     1440

acgaccagcc tggccaacat tgtgaaaccc catctctgcc aaaaatacaa aagttagccg     1500

ggcgtagtgg cacatgcctg taatcccagc tacccgggga ggctgaggca ggagaattgc     1560

ttgaactcag aaggcggagg ctgcagtgag ccgagatcgt gccactgcac tccagcctgg     1620

tcaacagagc aagactccat ctcg                                            1644


<210> 2318
<211> 1598
<212> DNA
<213> Homo sapiens

<400> 2318
agcctacacc gactctggag gaagactgga gcctttgcgg cggcgctgcc cctcccctgg       60

tccccgcgag ctcggagggc ccggctggtg ctgcgggggc cccgggagcg tgcttctgtt      120

cttcaaggtt gaaaactaag catggggaag agctgcaagg tggtcgtgtg tggccaggcg      180

tctgtgggca aaacttcaat cctggagcag cttctgtatg ggaaccatgt agtgggttcg      240

gagatgatcg agacgcagga ggacatctac gtgggctcca ttgagacaga ccggggggtg      300

cgagagcagg tgcgtttcta tgacacccgg gggctccgag atggggccga actgccccga      360

cactgcttct cttgcactga tggctacgtc ctggtctata gcacagatag cagagagtct      420

tttcagcgtg tggagctgct caagaaggag attgacaaat ccaaggacaa gaaggaggtc      480

accatcgtgg tccttggcaa caagtgtgac ttacaggagc agcggcgtgt agacccagat      540

gtggctcagc actgggccaa gtcagagaag gtgaagctgt gggaggtgtc agtggcggac      600

cggcgctccc tcctggagcc ctttgtctac ttggccagca agatgacgca accccagagc      660

aagtctgcct tccccctcag ccggaagaac aagggcagcg gctccttgga tggctgaaga      720

gctgccgttc ctctttcacg atcccagccc catttcagtg tctggggctc tggtagatgt      780

gttgagggca aagtagagga caagctgtct ttcccagtca gccagggagc tccccgccag      840

gccacgcccc agccactttg ctccctctca cctctgggaa gtgcaaatac tcttggttga      900

catccccttc ctcagccctc ccagcctact ccccatccca gcttttagag gatctgctcc      960

actgtctcct ggggcagttg tgggtcactg tcccttccag ctgccccaga caggaagcag     1020

agtcaccacg cagcagtgtc ccttcttggg tctgagttcc tattataggt aggggcccca     1080

ccctctgggc ttcccatcag cgacacacac acacttatgg caccagcctg gactccagaa     1140

aaagggtgtc caggtattgt gtgtatgcat ttagttgtgc acacacaaat atgctcctat     1200

actggcatta ggcgtctcct catccctcac cctgaccttt ctcctgtcct tttcttggct     1260

ggaagaagtt ggcctcctgg gagtgtagtt ttctgtttta aatcccccac ccctggctgg     1320

gctcagtggc tcacccctgt aatcccagca ctttgggagg ccaaggcggg tcgattactt     1380

gaggtcagga gttcacgacc agcctggcca acattgtgaa accccatctc tgccaaaaat     1440

acaaaagtta gccgggcgta gtggcacatg cctgtaatcc cagctacccg gggaggctga     1500

ggcaggagaa ttgcttgaac tcagaaggcg gaggctgcag tgagccgaga tcgtgccact     1560

gcactccagc ctggtcaaca gagcaagact ccatctcg                             1598


<210> 2319
<211> 2463
<212> DNA
<213> Homo sapiens

<400> 2319
ggcaggcggc gggggcgggg cctggaggag cctacaccga ctctggagga agactggagc       60

ctttgcggcg gcgctgcccc tcccctggtc cccgcgagct cggagggccc ggctggtgct      120

gcgggggccc cgggaggttg aaaactaagc atggggaaga gctgcaaggt ggtcgtgtgt      180

ggccaggcgt ctgtgggcaa aacttcaatc ctggagcagc ttctgtatgg gaaccatgta      240

gtggctatga tcgagacgca ggaggacatc tacgtgggct ccattgagac agaccggggg      300

gtgcgagagc aggtgcgttt ctatgacacc cgggggctcc gagatggggc cgaactgccc      360

cgacactgct tctcttgcac tgatggctac gtcctggtct atagcacaga tagcagagag      420

tcttttcagc gtgtggagct gctcaagaag gagattgaca aatccaagga caagaaggag      480

gtcaccatcg tggtccttgg caacaagtgt gacttacagg agcagcggcg tgtagaccca      540

gatgtggctc agcactgggc caagtcagag aaggtgaagc tgtgggaggt gtcagtggcg      600

gaccggcgct ccctcctgga gccctttgtc tacttggcca gcaagatgac gcaaccccag      660

agcaagtctg ccttccccct cagccggaag aacaagggca gcggctcctt ggatggctga      720

agagctgccg ttcctctttc acgatcccag ccccatttca gtgtctgggg ctctggtaga      780

tgtgttgagg gcaaagtaga ggacaagctg tctttcccag tcagccaggg agctccccgc      840

caggccacgc cccagccact ttgctccctc tcacctctgg gaagtgcaaa tactcttggt      900

tgacatcccc ttcctcagcc ctcccagcct actccccatc ccagctttta gaggatctgc      960

tccactgtct cctggggcag ttgtgggtca ctgtcccttc cagctgcccc agacaggaag     1020

cagagtcacc acgcagcagt gtcccttctt gggtctgagt tcctattata ggtaggggcc     1080

ccaccctctg ggcttcccat cagcgacaca cacacactta tggcaccagc ctggactcca     1140

gaaaaagggt gtccaggtat tgtgtgtatg catttagttg tgcacacaca aatatgctcc     1200

tatactggca ttaggcgtct cctcatccct caccctgacc tttctcctgt ccttttcttg     1260

gctggaagaa gttggcctcc tgggagtgta gttttctgtt ttaaatcccc cacccctggc     1320

tgggctcagt ggctcacccc tgtaatccca gcactttggg aggccaaggc gggtcgatta     1380

cttgaggtca ggagttcacg accagcctgg ccaacattgt gaaaccccat ctctgccaaa     1440

aatacaaaag ttagccgggc gtagtggcac atgcctgtaa tcccagctac ccggggaggc     1500

tgaggcagga gaattgcttg aactcagaag gcggaggctg cagtgagccg agatcgtgcc     1560

actgcactcc agcctggtca acagagcaag actccatctc gaagaaaaaa aaaaaaaatt     1620

ccccacccct accaattgtt ttacttcctc ttcctgctca gggagcagat gggcctcact     1680

ggttgagatg gaatagaata actgggctat gagtcaccag cccactttgt gacccagcaa     1740

gacctttccc ctctctgggc atcagtttct catctgtaag atgaccagag ttgcttagat     1800

gatctcctag atcctttcca gttctcttga tttcgtaaag ccaatggctt ctccctcttt     1860

aaggtgctat gccaaccagc cctggaggct gggatctgcc gctccctcca gccaccaggg     1920

ggcaggagtg cactacctgc tgtcagtcac cagagtggcc gctcagtgcc cagcccgcca     1980

gcctcgctct tggaggctgc tctttatcct gcctgtggtt ttcagctcag agctggactt     2040

ctatttataa gttacctgta tttatattta tatgcccgct ctcatggtga aggctggaca     2100

aggtgctcct ctggcccctc cttcttacct cagatgcctg aacagaacaa ggcaaacccg     2160

tagcagcctc tcaggagctg acaggtcctc tttcggggct caggagggtg ggcacacacc     2220

cagcggcctg cagagtaagc ttattaccca caactgtgcc cgctttgtgc ttctaaggtg     2280

cacacctagc ctaggtgaga cactgcagcc aggcaaccac cgacacacgc cccttctcaa     2340

agccagaggt gagtggggca ggtgcccggg gctgggtgag tggaattagg acacacacag     2400

gcttgggctt caagttcatt tattgatgca ttggttggac acaataaaac cacaattgtt     2460

atc                                                                   2463


<210> 2320
<211> 1863
<212> DNA
<213> Homo sapiens

<400> 2320
agcctacacc gactctggag gaagactgga gcctttgcgg cggcgctgcc cctcccctgg       60

tccccgcgag ctcggagggc ccggctggtg ctgcgggggc cccgggaggt tgaaaactaa      120

gcatggggaa gagctgcaag gtggtcgtgt gtggccaggc gtctgtgggc aaaacttcaa      180

tcctggagca gcttctgtat gggaaccatg tagtgggttc ggagatgatc gagacgcagg      240

aggacatcta cgtgggctcc attgagacag accggggggt gcgagagcag gtgcgtttct      300

atgacacccg ggggctccga gatggggccg aactgccccg acactgcttc tcttgcactg      360

atggctacgt cctggtctat agcacagata gcagagagtc ttttcagcgt gtggagctgc      420

tcaagaagga gattgacaaa tccaaggaca agaaggaggt caccatcgtg gtccttggca      480

acaagtgtga cttacaggag cagcggcgtg tagacccaga tgtggctcag cactgggcca      540

agtcagagaa ggtgaagctg tgggaggtgt cagtggcgga ccggcgctcc ctcctggagc      600

cctttgtcta cttggccagc aagatgacgc aaccccagag caagtctgcc ttccccctca      660

gccggaagaa caagggcagc ggctccttgg atggctgaag agctgccgtt cctctttcac      720

gatcccagcc ccatttcagt gtctggggct ctggtagatg tgttgagggc aaagtagagg      780

acaagctgtc tttcccagtc agccagggag ctccccgcca ggccacgccc cagccacttt      840

gctccctctc acctctggga agtgcaaata ctcttggttg acatcccctt cctcagccct      900

cccagcctac tccccatccc agcttttaga ggatctgctc cactgtctcc tggggcagtt      960

gtgggtcact gtcccttcca gctgccccag acaggaagca gagtcaccac gcagcagtgt     1020

cccttcttgg gtctgagttc ctattatagg taggggcccc accctctggg cttcccatca     1080

gcgacacaca cacacttatg gcaccagcct ggactccaga aaaagggtgt ccaggtattg     1140

tgtgtatgca tttagttgtg cacacacaaa tatgctccta tactggcatt aggcgtctcc     1200

tcatccctca ccctgacctt tctcctgtcc ttttcttggc tggaagaagt tggcctcctg     1260

ggagtgtagt tttctgtttt aaatccccca cccctggctg ggctcagtgg ctcacccctg     1320

taatcccagc actttgggag gccaaggcgg gtcgattact tgaggtcagg agttcacgac     1380

cagcctggcc aacattgtga aaccccatct ctgccaaaaa tacaaaagtt agccgggcgt     1440

agtggcacat gcctgtaatc ccagctaccc ggggaggctg aggcaggaga attgcttgaa     1500

ctcagaaggc ggaggctgca gtgagccgag atcgtgccac tgcactccag cctggtcaac     1560

agagcaagac tccatctcga agaaaaaaaa aaaaaattcc ccacccctac caattgtttt     1620

acttcctctt cctgctcagg gagcagatgg gcctcactgg ttgagatgga atagaataac     1680

tgggctatga gtcaccagcc cactttgtga cccagcaaga cctttcccct ctctgggcat     1740

cagtttctca tctgtaagat gaccagagtt gcttagatga tctcctagat cctttccagt     1800

tctcttgatt tcgtaaagcc aatggcttct ccctctttaa ggtgctatgc caaccagccc     1860

tgg                                                                   1863


<210> 2321
<211> 1302
<212> DNA
<213> Homo sapiens

<400> 2321
tcgaacggga tggcagagga ggtgaggagg gaggaagcgt ccggagtggg gcgggcccgg       60

actccgaccc ccggggcgct tcgagccccc cagctggtca ccgaggcacc gccgcttcac      120

ccaggccaca ccctgatgaa ggccacggtc ctgatgcggc agcctgggcg ggtgcaggag      180

atcgtgggcg ccctccgcaa gggcggcgga gaccggttac aggtgatttc tgattttgac      240

atgaccttga gcaggtttgc atataatgga aagcgatgcc cttcttctta caatattctg      300

gataatagca agatcatcag tgaggagtgt cggaaagagc tcacagcgct ccttcaccac      360

tattacccaa ttgagatcga cccacaccgg accgtcaagg agaagctacc tcatatggtg      420

gaatggtgga ccaaagcaca caatctccta tgtcagcaga agattcagaa gtttcagata      480

gcccaggtgg ttagagagtc caatgcaatg ctcagggagg gatataagac cttcttcaac      540

acactctacc ataacaacat tccccttttc atcttttctg cgggcattgg tgatatcctg      600

gaagaaatta tccgacagat gaaagtgttc caccccaaca tccacatcgt gtctaactac      660

atggatttta atgaagatgg ttttctccag ggatttaagg gccagctcat acacacatac      720

aacaagaaca gctctgcgtg tgagaactct ggttacttcc agcaacttga gggcaaaacc      780

aatgtcatcc tgctgggaga ctctatcggg gacctcacca tggccgatgg ggttcctggt      840

gtgcagaaca ttctcaaaat tggcttcctg aatgacaagg tggaggagcg gcgggagcgc      900

tacatggact cctatgacat cgtgctggag aaggacgaga ctctggatgt ggtcaacggg      960

ctactgcagc acatcctgtg ccagggggtc cagctggaga tgcaaggccc ctgaaggcgc     1020

aggctccagc ccggcctgca ggccgtggtg aggaggggcg cctccccaga gtctgctccc     1080

ccgtgaacac agagcagagg ccagggtggc cagcagtggc tgggtccttc cgcgcccctc     1140

cgtcctcctt tccctgagca ccttcatcac cagaggcttg aaggaacccc gccatgtggc     1200

agggcacagg cactgttcct ggtgaacctt ggaccacagc atgtcagtgc tctagggatt     1260

gtctactcca gggattttct tcaaaatttt taaacatggg aa                        1302


<210> 2322
<211> 1058
<212> DNA
<213> Homo sapiens

<400> 2322
gaaacagggg ataatacggc ggagccgcct gggctgcagt cccacccggg agccggcagg       60

gagcggagct gcggagccgc ctggtctccc gcgtccatcg gtccattcct gcgtcgttct      120

gtccttccga acgcacactt caggagcagc cgcgagggtg gcatggcagc gagcacagac      180

atggctgggc tggaggagag cttccgcaag tttgccatcc atggtgaccc caaggccagt      240

gggcaagaga tgaatggcaa gaactgggcc aagctgtgca aggactgcaa ggtggctgac      300

ggaaagtccg tgacagggac cgatgtggac atcgtcttct ccaaagtcaa ggggaagtct      360

gctcgggtca tcaactatga ggagttcaag aaggccctgg aagagctggc gaccaagaga      420

ttcaagggga agagcaagga ggaggccttc gatgccatct gccagctggt ggcaggcaaa      480

gagccagcca atgtgggcgt cactaaagca aaaacagggg gtgctgtaga ccggctgacg      540

gacaccagca gatacacggg ctcccacaag gagcgcttcg atgagagcgg caagggcaag      600

ggcattgcgg gacggcagga catcctggac gacagtggct acgtgagcgc ctacaagaat      660

gcaggcacct acgatgccaa ggtgaagaag tgaggcttgg gaagaccgcc ctgccaagtg      720

cggctgcccc tgccagaggc tcaggcctgg gtctaagggg cacgtggagc aagagatcct      780

ggtcccctcc ctgctggacc tgccacccag agcttcctgc ctagtcccac tgggctggcc      840

caccaggcct ctgacccagg ctgctctgcg gccccttcct cctcctcttc ctgctccaac      900

ttctgtccac ctggggacag tctgtgcctg tagcctcatg accccaaccc agccccaggc      960

atggctaacc cctgactgct tgcctcatat ttaagctgct gctctggcca agtgcctaat     1020

tttaacccag acctcaataa agacaccttt tgtaccaa                             1058


<210> 2323
<211> 1331
<212> DNA
<213> Homo sapiens

<400> 2323
ggatccggtc gggctccgga agtccctagg caccctaggg gaccgttctc ggtgacggcc       60

ggggtgggcc aggggtcgag gtgatttgtg ggtccaggac gggggttggg agctgccccc      120

gctaacccac cctcgtctga gaggccgcga ggtttcggcc tgagatcccg tgaaggcgag      180

aaatctcgcg atttctcggg agaggaatcg gttaggagaa gggggattcc tcactcagct      240

gtgcgctctg atttcgtgcg cttcctcgtc cttcatgttg gatggccagt ttttcgtttg      300

tgcgtcatcc tctacctgag aaatggtcgc ttgcccctag tctagacacg cattaaaggg      360

cagtatttaa agtcagttgg caagcagtgg aataagattt ttgtaaagaa accttgtgca      420

gcatggattc tctaccagat gaattttttg tgaggcatcc tgctgtggag gatcagagga      480

aggaagaaac tgagaataag ctagaaaaat catctggtca actgaacaaa caggaaaatg      540

acatacctac tgatcttgtc cctgttaacc tactattaga agtgaagaag ttattaaatg      600

caattaatac tctaccaaaa ggtgtggttc ctcacattaa gaagttctta caagaagatt      660

tttccttcca aactatgcag agagaagttg cagctaacag ccagaatggt gaggaaattg      720

ttcctgcttt gactttacgt ttcttgatta cacagctaga agcagcactt aggaacattc      780

aagctggcaa ttataccgca caccagatta atattggtta ttatttgaca ttactgtttt      840

tatatggagt agcactcact gaaagaggaa agaaagagga ttatacagaa gctgagaata      900

aatttctggt gatgaagatg atgatccaag aaaatgaaat ttgtgaaaac tttatgtctt      960

tagtttattt tggacgtggt ttactgcgat gtgctcaaaa gagatataat ggaggactgc     1020

tagaatttca taaaagctta caagaaattg gagacaaaaa tgaccattgg tttgacatag     1080

atcctacaga agatgaagat ttacctacaa cttttaaaga tcttcttaat aattttatca     1140

agacaactga aagcaatata atgaagcaga cgatttgtag ttacctagat tgtgaacgat     1200

cttgtgaagc tgacattttg aagaacacca gttataaggg attttttcag ttaatgtgca     1260

gtaaaagttg ctgtgtttat ttccataaaa tttgctggaa aaagttcaag aatttaaagt     1320

atccaggatt t                                                          1331


<210> 2324
<211> 2301
<212> DNA
<213> Homo sapiens

<400> 2324
gtgggcagct ccccgctctg ccgctgccgc cgccgtcgcc caaggaggat cggggccggg       60

ccgggccggg atgatccggg tcggaaggcc gccgccgccg gagggagcgg gtcacccaac      120

gccgcactga gccgcccccg ccccgccccg gccccggggg atgcgccgcc ccgagctgct      180

gcctccgccg ccgccgcagc cgcagccgca gcgggcacag agcaggtaga tggccccctc      240

agggcaggcc cggcggacac ccctccctct ggctggcgga tgcagtgcct agcggccgcc      300

cttaaggacg aaaccaacat gagtggggga ggggagcagg ccgacatcct gccggccaac      360

tacgtggtca aggatcgctg gaaggtgctg aaaaagatcg ggggcggggg ctttggtgag      420

atctacgagg ccatggacct gctgaccagg gagaatgtgg ccctcaaggt ggagtcagcc      480

cagcagccca agcaggtcct caagatggag gtggccgtgc tcaagaagtt gcaagggaag      540

gaccatgtgt gcaggttcat tggctgtggc aggaacgaga agtttaacta tgtagtgatg      600

cagctccagg gccggaacct ggccgacctg cgccgtagcc agccgcgagg caccttcacg      660

ctgagcacca cattgcggct gggcaagcag atcttggagt ccatcgaggc catccactct      720

gtgggcttcc tgcaccgtga catcaagcct tcaaactttg ccatgggcag gctgccctcc      780

acctacagga agtgctatat gctggacttc gggctggccc ggcagtacac caacaccacg      840

ggggatgtgc ggccccctcg gaatgtggcc gggtttcgag gaacggttcg ctatgcctca      900

gtcaatgccc acaagaaccg ggagatgggc cgccacgacg acctgtggtc cctcttctac      960

atgctggtgg agtttgcagt gggccagctg ccctggagga agatcaagga caaggaacag     1020

gtagggatga tcaaggagaa gtatgagcac cggatgctgc tgaagcacat gccgtcagag     1080

ttccacctct tcctggacca cattgccagc ctcgactact tcaccaagcc cgactaccag     1140

ttgatcatgt cagtgtttga gaacagcatg aaggagaggg gcattgccga gaatgaggcc     1200

tttgactggg agaaggcagg caccgatgcc ctcctgtcca cgagcacctc taccccgccc     1260

cagcagaaca cccggcagac ggcagccatg tttggggtgg tcaatgtgac gccagtgcct     1320

ggggacctgc tccgggagaa caccgaggat gtgctacagg gagagcacct gagtgaccag     1380

gagaatgcac ccccaattct gcccgggagg ccctctgagg ggctgggccc cagtccccac     1440

cttgtccccc accccggggg tcctgaggct gaagtctggg aggagacaga tgtcaaccgg     1500

aacaaactcc ggatcaacat cggcaaaagc ccctgtgtgg aggaggaaca gagccgaggc     1560

atgggggtcc ccagctcccc agtgcgtgcc cccccagact cccccacaac cccagtccgt     1620

tctctgcgct accggagggt gaacagccct gagtcagaaa ggctgtccac ggcggacggg     1680

cgagtggagc tacctgagag gaggtcacgg atggatctgc ctggctcgcc ctcgcgccag     1740

gcctgctcct ctcagccagc ccagatgctg tcagtggaca caggccacgc tgaccgacag     1800

gccagtggcc gcatggacgt gtcagcctct gtggagcagg aggccctgag caacgccttc     1860

cgctcggtgc cgctggctga ggaggaggat ttcgacagca aagagtgggt catcatcgac     1920

aaggagacgg agctcaagga cttccctcca ggggctgagc ccagcacatc gggcaccacg     1980

gatgaggagc ccgaggagct gcggccactg cccgaggagg gcgaagagcg gcggcggctg     2040

ggggcagagc cccccttccc actcacccct gcactcggga ccccgccctc gacggagaga     2100

gtcggacccc acaggcccac agagacagtt ggaggaggac agactctcgg ggcactccct     2160

cccgcggtac agccccctgc gacgactggc gtcctccgtg ttctcctcct ccacgctgga     2220

gacggagcat taccctcacc ccggcggcgg cggctcctcg ggctcctccg gttccctcat     2280

tcagcgcagc cgctcggctg a                                               2301


<210> 2325
<211> 796
<212> DNA
<213> Homo sapiens

<400> 2325
ggagagcgcg ggcggctggg gaatggctgc tgccatggtg ccggggcgca gcgagagctg       60

ggagcgcggg gagcctggcc gcccggccct gtacttctgc gggagcattc gcggcggacg      120

cgaggacagg acgctgtacg agcggatcgt gtctcggctg cggcgattcg ggacagtgct      180

caccgagcac gtggcggccg ccgagctggg cgcgcgcggg gaagaggctg ctgggggtga      240

caggctcatc catgagcagg acctggagtg gctgcagcag gcggacgtgg tcgtggcaga      300

agtgacacag ccatccttgg gtgtaggcta tgagctgggc cgggccgtgg cctttaacaa      360

gcggatcctg tgcctgttcc gcccgcagtc tggccgcggt gagcacccca agcctccctc      420

ctggctttct atggacccag ccctcagctc cttccctggt gggctctgag caccgcgcct      480

ctcccaaggg gtaagggagc tgtgagggtg tggatgggag gcagcttcac ctttccctgc      540

cctttccagt gctttcggcc atgatccggg gagcagcaga tggctctcgg ttccaggtgt      600

gggactatga ggagggagag gtggaggccc tgctggatcg atacttcgag gctgatcctc      660

cagggcaggt ggctgcctcc cctgacccaa ccacttgact taatctcact ttcttaaatt      720

cttctattct cagacactgc tctagtacca ttccttcctc ttagccccag gagcaaatta      780

aaaggtacag ttaaaa                                                      796


<210> 2326
<211> 1077
<212> DNA
<213> Homo sapiens

<400> 2326
ctcactctcc tggaaaccca ccgagaacct ccaccctctg acaccatggt caactcctgt       60

tgtggctctg tgtgctctga ccagggctgt ggcctggaga actgctgccg ccccagctgc      120

tgccagacca cctgctgcag gaccacctgc tgccgcccca gctgctgtgt gtccagctgc      180

tgcaggcccc agtgctgcca gtctgtgtgc tgtcagccca cctgctgccg ccccagctgc      240

tgtcagacca cctgctgtag gaccacctgc tgccgcccca gctgctgtgt gtccagctgc      300

tgcagacccc agtgctgcca gtctgtgtgc tgccagccca cctgctgccg ccccagctgc      360

tgtcagacca cctgctgcag gaccacttgc tgccgcccca gctgctgtgt gtccagctgc      420

tgcagacccc agtgctgcca gtctgtgtgc tgccagccca cctgctgccg ccccagctgc      480

tgcatctcca gcagctgctg cccctcttgc tgtgaatcca gctgctgccg cccctgctgc      540

tgcctgcgtc cagtctgtgg ccgagtctcc tgccacacca cttgctatcg cccaacctgt      600

gtcatctcca cctgcccccg ccccttgtgc tgtgcctcct cttgctgcta aatctctgct      660

gtgaacacac cacttcctta ttacgtcctt tcctacagat gaaggctctc attgcaaaca      720

tgcggactgt tcaagagaat tgatctgggt cccataagca aacctcatcc ttagaaattc      780

tgtatttgca ttctaccttt tgtccaaact cccttccttc caaaggaatt cattgacaat      840

ctcctaataa attgacaaat tgtcctccaa catcctccca cctctttgac ttcaggacat      900

ttattcatca tgcctaagga atttgaagat tgcctccatc atttgtaggg ccacagatct      960

taaagcctcc aaccttgaag tccagtgaag tctctctctt aaagtctttt gcaaacattt     1020

ttgtaccttg ttatttccat gtaccaaaat aaacctctat tctattggca ctgaaaa        1077


<210> 2327
<211> 763
<212> DNA
<213> Homo sapiens

<400> 2327
aatagcccaa cccacaccag cctcagacac caccatgacc ggctcctgct gcggctccac       60

cttgtcctcc ctgagctacg ggggaggctg ctgccagccc tgctgctgcc gcgacccctg      120

ctgctgccgc cccgtgacct gccagaccac cgtgtgccgc cccgtgacct gcgtgccccg      180

ctgcacgcgc cccatctgcg agccctgccg ccgcccggtg tgctgcgacc cctgctccct      240

gcaggaaggc tgctgccgcc ccatcacctg ctgcccctcg tcgtgcacgg ctgtggtgtg      300

caggccctgc tgctgggcca ccacctgctg ccagcctgtg tctgtgcagt ccccctgctg      360

ccggcccccc tgcggccagc cgaccccttg cagcaccacc tgcaggacct cctcctgctg      420

agaccccaat gcccccacag agcaatacac tgaagcctaa acatctatct ggtgttttta      480

aaaagttaaa agaaaaatag attttttttc acaaggtgac aatagtgatt tttaccatct      540

ggatacagcc tggtgtaagc agacgtccat taccaccctc acccacattt tcaggtgtct      600

acatcagcct tagtcattat ggatagtaaa tcgaccttta agaattcctg gggtggactt      660

tgcaaacaca ttctacaacc tgatggtttt tactgctcaa actgtcacca tcatcttttg      720

caatgtgttg ctcactgttg tcaataaact aatttttcct ggc                        763


<210> 2328
<211> 1458
<212> DNA
<213> Homo sapiens

<400> 2328
aagaaggcac tccattctgg ctttcacaaa tacagctctg caacgcgttt gccctgatac       60

catgtctctt cgactttcca gtgcatccag gaggtcctgt cctcgtccca ccactggatc      120

actcagactc tatggtgggg gaaccagctt tggtactgga aattcttgtg gcatttcagg      180

gattggaagt ggcttctcta gtgccttcgg aggcagctca tcgggaggaa acacaggggg      240

aggtaatccc tgtgctggct tcactgtgaa tgagcggggg ctcctttctg gcaatgagaa      300

ggtgaccatg cagaacctca atgaccgcct ggcatcctac ctggacagtg tgcatgctct      360

ggaggaggcc aacgctgacc tggagcagaa gatcaagggc tggtatgaga aatttgggcc      420

tggctcttgc cgtggtcttg atcatgacta tagcagatat ttcccaataa ttgatgacct      480

taaaaatcag atcatcgcat ccaccaccag caatgctaat gctgttctgc agatcgataa      540

tgccaggctt acagctgatg atttcagact caagtatgaa aatgagctgg ctcttcacca      600

gagtgtagag gctgatgtca atgggttacg aagagttttg gatgaaataa ccctgtgcag      660

aacagatctg gagattcagt atgaaaccct gagtgaggag atgacttacc tcaaaaagaa      720

ccataaagag gaaatgcaag ttctgcagtg cgcagctgga ggcaacgtga acgtggaaat      780

tgaacttcag tctctcctag ccacgaaaca ctccctggag tgctccttga cagagaccga      840

gagcaactac tgtgcgcagc tggcgcagat ccaggctcag atcggggccc tggaggagca      900

gctgcaccag gtcagaaccg agaccgaggg ccagaagctg gagtatgagc agctcctgga      960

catcaagctc cacctggaaa aagaaattga gacctactgt ctccttatag gaggagatga     1020

tggagcctgt aagtctgggg gttacaagtc taaagattat ggatctggaa atgtgggaag     1080

tcaagtcaaa gacccagcca aagccatagt ggttaagaaa gttcttgagg aggtagacca     1140

acgcagcaaa atacttacca ccaggctcca ctccctggaa gagaaatctc aaagcaatta     1200

atttgagatg caacagagaa cgtatgccac atagcccctg cgaagaaaag gcattatgta     1260

tctgtccaga aaaatgtgca tgtctaagaa aaatgtctaa cctgttgtct ttctgttact     1320

ttctttctgg gcaatcaatg acagcatctc cccattcatc tagaagaatg ccacacacaa     1380

atatgactca tttgattatc ctacagaaat ctgttgtcaa ttctttgtat tcaataaacc     1440

tcttctttag caagttat                                                   1458


<210> 2329
<211> 2764
<212> DNA
<213> Homo sapiens

<400> 2329
gcagcgactc atcctatcga taaggttcag ttagccaagg tggaggatgg gaaaagaatg       60

gaactgtccc agctactcaa tgagatcagg gcaaactatg aaaagatcct caccagaaat      120

cagatagaga cggtgctctc aacaaggatc caggtaatga tttcatacag acaggcacct      180

tccagaataa ggagacagtc catgtctacc caattcctgt cccggcctct ctgagctaga      240

agaagacata agcaaaaaaa tggacaaaga tgaagaggct ttgaaggcag ctcaagcaga      300

actcaaggag gcccgacgcc agtggcacca cctgcaagtg gaaattgaat ctctccatgc      360

tgtggaaagg ggccttgaaa actccctaca tgccagcgag cagcattacc agatgcagct      420

gcaagaccta gagactgtga ttgaaggact agaaaaagag ctacaggaag taaggcgcgg      480

catcgaaaag cagcttcaag agcacgagat gcttctcaac acgaagatga ggctggaaca      540

agaaatagca acttatcgcc acctcctaga aaaagaagaa atcagatatt atggttgtat      600

ccaaggtggg aaaaaagaca aaaagcctac cacaagtaga gttggttttg ttttaccatc      660

agccattata aatgaaatat cttttactac aaaagtccca caaaagtatg agaatgaaaa      720

tgtagaaaca gtaaccaaac aggcaatctt aaatgggagt atcgttaagg agagcactga      780

agctcatggc actattcaga cagagaaagt ggatgaagtt attaaagaat gggaaggttc      840

tttctttaaa gataaccctc gattgaggaa aaagtctgtt tctcttcgat ttgatcttca      900

tttagcagcc actgatgaag ggtgtttaga gactaagcag gataatctac cagatataga      960

agtcaggctt atcatgagaa gatcatgcag tattccctct atcaaacctc catcaacagc     1020

taattaatcc aaagatagta tttgacttga ttggaaaatg ttaggatgga ccaaggtggg     1080

ccataccaac tccctctgtc ccaaaatgta agttattacg tatgtatgga aaatgttatg     1140

atcaatatgt ggttctcttc agaagaaaaa aacaataaag gacatttctc tgaatctaat     1200

tatggagata gacatatata tatatatatg aatgagaggg agtagcttaa aaataaaatc     1260

acaaatccag tacagtctct ttctttatat tctcccaata gtcttctttt tcccttgaaa     1320

cttcatcaga gactgtaagc attaacctgg tttagtaaag tctttgtaat ttttttcaat     1380

ggctgaatac gctaaggaaa aaagaattgt ttgaatagga ttgtgttaag agtcacactg     1440

agttattcac cattattcca tgactggtta aacctacaat gtttgttcta tttttcaaaa     1500

agagcaatta taaacaagtt tttaaagggg gactcactat tcacctaatg aggattcttc     1560

tttttgagat aaatcatttg tatactgaga aaaatgagtt attttccatg agaaattctg     1620

agcaaactat agaacacacc ccagggctaa tttgagataa gtacaattaa gttaatctac     1680

atatatctaa aaggtttttt ttgtaataag tatctgattt ccggaagatt tactttactc     1740

aaggaacttt aaaggttgta tcccccacca aaaaaagaaa aaaaatcaga aggccaactg     1800

cgcaaacaaa acatgaaaag caaattgaaa aggtagttac tatagttatc agaacagtta     1860

cccaccatcc cagtttttcc aactgtaaag ctaaatgtga ttagattgtt tgctataagc     1920

cgtagataag atactatatg aagtattata aatatttctt gcaatcattt atgtgaacta     1980

agataacggt attgttatct aagctaagag tatttagagg atttgttttt aaatcgttca     2040

aattgtaata aatatgggta gaaaatatat ttgtgaataa gtgaggtatt gttgcaaagt     2100

ttttaaaata acctaatttg tttaatacag gtatatttaa gatcttaata aatacctgtt     2160

ttaagacatt agaaatttat aagttcttaa ttcttttcta agcagaaaaa gtagctgagt     2220

acaactcacc atactttttc ccagctaaag tatcatctaa gggctatagc tacgttagca     2280

ttttagtaca gcctttaaaa tatttctctc tctctctcct ctctcttctc ctctatctct     2340

ctctccatat atacttatta tatatataca tatatataat ttatatatat gtatatatat     2400

atttcaacca gaaaaatgta tgttttaacc aggaaaatat tatgttaaat aatctttaac     2460

ataatacagg gatataaaat ttttaatttt ctttcaatta cttcagattc cttttagtct     2520

ggtttattct atttagtgaa aagggatgat tttgttttgt caaggatata acagcatgtt     2580

aagtgcttat tcttgcataa gcatctgacc taaaatacat cctatacata aaaaatgttt     2640

catttgatat tgctaaatgc tactaacttt attaaagctt taaaaatgca atcatataag     2700

ctattgtact aaagttactg tactaagcaa cagtgatcat aataaagcaa tatatctagc     2760

ataa                                                                  2764


<210> 2330
<211> 1102
<212> DNA
<213> Homo sapiens

<400> 2330
atcgataagg ttcagttagc caaggtggag gatgggaaaa gaatggaact gtcccagcta       60

ctcaatgaga tcagggcaaa ctatgaaaag atcctcacca gaaatcagat agagacggtg      120

ctctcaacaa ggatccagct agaagaagac ataagcaaaa aaatggacaa agatgaagag      180

gctttgaagg cagctcaagc agaactcaag gaggcccgac gccagtggca ccacctgcaa      240

gtggaaattg aatctctcca tgctgtggaa aggggccttg aaaactccct acatgccagc      300

gagcagcatt accagatgca gctgcaagac ctagagactg tgattgaagg actagaaaaa      360

gagctacagg aagtaaggcg cggcatcgaa aagcagcttc aagagcacga gatgcttctc      420

aacacgaaga tgaggctgga acaagaaata gcaacttatc gccacctcct agaaaaagaa      480

gaaatcagat attatggttg tatccaaggt gggaaaaaag acaaaaagcc taccacaagt      540

agagttggtt ttgttttacc atcagccatt ataaatgaaa tatcttttac tacaaaagtc      600

ccacaaaagt atgagaatga aaatgtagaa acagtaacca aacaggcaat cttaaatggg      660

agtatcgtta aggagagcac tgaagctcat ggcactattc agacagagaa agtggatgaa      720

gttattaaag aatgggaagg ttctttcttt aaagataacc ctcgattgag gaaaaagtct      780

gtttctcttc gatttgatct tcatttagca gccactgatg aagggtgttt agagactaag      840

caggataatc taccagatat agaagtcagg cttatcatga gaagatcatg cagtattccc      900

tctatcaaac ctccatcaac agctaattaa tccaaagata gtatttgact tgattggaaa      960

atgttaggat ggaccaaggt gggccatacc aactccctct gtcccaaaat gtaagttatt     1020

acgtatgtat ggaaaatgtt atgatcaata tgtggttctc ttcagaagaa aaaaacaata     1080

aaggacattt ctctgaatct aa                                              1102


<210> 2331
<211> 2770
<212> DNA
<213> Homo sapiens

<400> 2331
agtgacctcg gggtcgttag gcctccacgt cctcgctgga gctgcggacc tcagtcgtcc       60

atccacacct cccccctgcc gcccccgccc atctcactct cccaaccctg ggcaccaggg      120

caggtcgaca gcccgaggca ctcctctact gcgtttccag gcccaggaga cccactccag      180

cgccgcggtt ccttgcgacc cggcagccgt tcagcagacc tcccattctt tcctgcatca      240

tcgggcattg tggaggcacc ctacggtgat tcctctcaga gcctgtttgt aggtgaccgt      300

gacagagaca aaaccatgga agtgactggg tttggagtga ccaggtgttc ctccctcccc      360

tttcccagac acgcctcttg ctggcagatc ctctgactct ctggctgcag aacagtttct      420

tccgtgctct ggcctgagtg ccacagccag ggcctctgct ctgtacacag accgggcaag      480

gtcccccagg ccaggatgtc aggcctggtg ttggggcagc gggatgagcc tgcaggccac      540

cggctcagcc aagaggagat cctggggagc acacggctgg tcagccaagg gctagaggcc      600

ctacgcagtg aacaccaggc cgtgctgcaa agcctgtccc agaccattga gtgtctgcag      660

cagggaggcc atgaggaagg gctggtgcat gagaaggccc ggcagcttcg ccgttctatg      720

gaaaacattg agctcgggct gagtgaggcc caggtgatgc tggctctagc cagccacctg      780

agcacagtgg agtcggagaa acagaagctg cgggctcagg tgcggcggct atgccaggag      840

aaccagtggc tgcgggatga gctggctggc acccagcagc ggctacagcg cagtgaacag      900

gctgtggctc agctggagga ggaaaagaag cacctggagt tcctggggca gctgcggcag      960

tatgatgagg atggacatac ctcggaggag aaagaaggcg atgccaccaa ggattccctg     1020

gatgacctct ttcctaatga ggaggaagag gaccccagca atggcttgtc ccgtggtcaa     1080

ggtgctacag cagctcagca gggtggatat gagatcccag caaggttgcg gacgttgcac     1140

aacctggtga tccagtacgc agcccaaggt cgctatgagg tggccgtgcc actctgtaag     1200

caggcactag aggacctgga gcgcacatca ggccgtggcc accctgatgt cgccaccatg     1260

ctcaacatcc ttgctttggt gtatcgtgac cagaataagt ataaggaagc tgcccacctg     1320

ctgaatgatg cccttagcat ccgggagagc accttgggac ctgaccatcc tgctgtggct     1380

gccacactca acaatttggc tgtgctctat ggcaaaaggg gcaagtacaa ggaggcagag     1440

cctctgtgcc agcgggcact ggagattcga gaaaaggtcc tgggcacgaa tcatccagat     1500

gtggcaaaac agctgaacaa cctggccctc ttgtgccaaa accagggcaa gtatgaggcc     1560

gtggaacgct actaccagcg agcactggcc atctacgagg ggcagctggg gccggacaac     1620

cctaatgtag cccggaccaa gaacaacctg gcttcctgtt acctgaaaca gggcaaatat     1680

gctgaggctg agacactata caaagagatc ctgacccgtg cccatgtaca ggagtttggg     1740

tctgtggatg atgaccacaa gcccatctgg atgcatgcag aggagcggga ggaaatgagc     1800

aaaagccggc accatgaggg tgggacaccc tatgctgagt atggaggctg gtacaaggcc     1860

tgcaaagtga gcagccccac agtgaacact actctgagaa acctgggagc tctgtatagg     1920

cgccagggaa agctggaggc tgctgagacc ctggaggaat gtgccctgcg gtcccggaga     1980

cagggcactg accctatcag ccagacgaag gtggcagagc tgcttgggga gagtgatggt     2040

agaaggacct cccaggaggg ccctggagac agtgtgaaat tcgagggagg tgaagatgct     2100

tctgtggctg tggagtggtc cggggatggc agtgggaccc tgcagaggag tggctctctt     2160

ggcaagatcc gggatgtgct ccgcagaagc agtgaactct tggtgaggaa gctccagggg     2220

actgagcctc ggccctccag cagcaacatg aagcgagcag cctccttgaa ctatctgaac     2280

caacctagtg cagcacccct ccaggtctcc cggggcctca gtgccagcac catggacctc     2340

tcttcaagca gctgacattc aacccggccc ccaggtctgc tgggtccccc cacccccaca     2400

gccctcacag cattccccat tgctcctggc tcttccccac ccctaggtgg gacagtgaag     2460

gggagcagtt taaccagaag attgctgctg cccttagggt ctcagctccc tcctcaggaa     2520

tccctcttag gaaggaccct caggacaccc tctctgcacc ctgtggtcct ctagagtagc     2580

tagctctgag gccccaaggt gggtacaaag caggtatggc cctcagagat gcagcctgct     2640

gctggctttt cagtcagagg gttgggggct ggccagccaa gctgccttgc cctggccgct     2700

cttactccct ccctctgctg tctcacttca ggtccatgta tttcactttt cttaaataaa     2760

agaatcaggt                                                            2770


<210> 2332
<211> 2470
<212> DNA
<213> Homo sapiens

<400> 2332
gggccaggtc ctctgggtag ctgtgaagtg gtgaaagaag gggtgggaac gctggacttc       60

tggactttgg gcagggcaga tcctctgact ctctggctgc agaacagttt cttccgtgct      120

ctggcctgag tgccacagcc agggcctctg ctctgtacac agaccgggca aggtccccca      180

ggccaggatg tcaggcctgg tgttggggca gcgggatgag cctgcaggcc accggctcag      240

ccaagaggag atcctgggga gcacacggct ggtcagccaa gggctagagg ccctacgcag      300

tgaacaccag gccgtgctgc aaagcctgtc ccagaccatt gagtgtctgc agcagggagg      360

ccatgaggaa gggctggtgc atgagaaggc ccggcagctt cgccgttcta tggaaaacat      420

tgagctcggg ctgagtgagg cccaggtgat gctggctcta gccagccacc tgagcacagt      480

ggagtcggag aaacagaagc tgcgggctca ggtgcggcgg ctatgccagg agaaccagtg      540

gctgcgggat gagctggctg gcacccagca gcggctacag cgcagtgaac aggctgtggc      600

tcagctggag gaggaaaaga agcacctgga gttcctgggg cagctgcggc agtatgatga      660

ggatggacat acctcggagg agaaagaagg cgatgccacc aaggattccc tggatgacct      720

ctttcctaat gaggaggaag aggaccccag caatggcttg tcccgtggtc aaggtgctac      780

agcagctcag cagggtggat atgagatccc agcaaggttg cggacgttgc acaacctggt      840

gatccagtac gcagcccaag gtcgctatga ggtggccgtg ccactctgta agcaggcact      900

agaggacctg gagcgcacat caggccgtgg ccaccctgat gtcgccacca tgctcaacat      960

ccttgctttg gtgtatcgtg accagaataa gtataaggaa gctgcccacc tgctgaatga     1020

tgcccttagc atccgggaga gcaccttggg acctgaccat cctgctgtgg ctgccacact     1080

caacaatttg gctgtgctct atggcaaaag gggcaagtac aaggaggcag agcctctgtg     1140

ccagcgggca ctggagattc gagaaaaggt cctgggcacg aatcatccag atgtggcaaa     1200

acagctgaac aacctggccc tcttgtgcca aaaccagggc aagtatgagg ccgtggaacg     1260

ctactaccag cgagcactgg ccatctacga ggggcagctg gggccggaca accctaatgt     1320

agcccggacc aagaacaacc tggcttcctg ttacctgaaa cagggcaaat atgctgaggc     1380

tgagacacta tacaaagaga tcctgacccg tgcccatgta caggagtttg ggtctgtgga     1440

tgatgaccac aagcccatct ggatgcatgc agaggagcgg gaggaaatga gcaaaagccg     1500

gcaccatgag ggtgggacac cctatgctga gtatggaggc tggtacaagg cctgcaaagt     1560

gagcagcccc acagtgaaca ctactctgag aaacctggga gctctgtata ggcgccaggg     1620

aaagctggag gctgctgaga ccctggagga atgtgccctg cggtcccgga gacagggcac     1680

tgaccctatc agccagacga aggtggcaga gctgcttggg gagagtgatg gtagaaggac     1740

ctcccaggag ggccctggag acagtgtgaa attcgaggga ggtgaagatg cttctgtggc     1800

tgtggagtgg tccggggatg gcagtgggac cctgcagagg agtggctctc ttggcaagat     1860

ccgggatgtg ctccgcagaa gcagtgaact cttggtgagg aagctccagg ggactgagcc     1920

tcggccctcc agcagcaaca tgaagcgagc agcctccttg aactatctga accaacctag     1980

tgcagcaccc ctccaggtct cccggggcct cagtgccagc accatggacc tctcttcaag     2040

cagctgacat tcaacccggc ccccaggtct gctgggtccc cccaccccca cagccctcac     2100

agcattcccc attgctcctg gctcttcccc acccctaggt gggacagtga aggggagcag     2160

tttaaccaga agattgctgc tgcccttagg gtctcagctc cctcctcagg aatccctctt     2220

aggaaggacc ctcaggacac cctctctgca ccctgtggtc ctctagagta gctagctctg     2280

aggccccaag gtgggtacaa agcaggtatg gccctcagag atgcagcctg ctgctggctt     2340

ttcagtcaga gggttggggg ctggccagcc aagctgcctt gccctggccg ctcttactcc     2400

ctccctctgc tgtctcactt caggtccatg tatttcactt ttcttaaata aaagaatcag     2460

gtaacctttc                                                            2470


<210> 2333
<211> 1494
<212> DNA
<213> Homo sapiens

<400> 2333
ctcgttgggg actaaggcgt cggttggcgc gcaacgggtt ctaggctgca ggcagctcga       60

ggacccgcgg ccccgccccg gctcggcctg gcagatagca gaggcagcag gccgtgccgg      120

gggggcatgt tgctgtaacc agtggcccag gggatgttac ggtggacagt gcacctggag      180

ggcgggcccc gcagggtgaa ccatgctgca gtggctgtcg ggcatcgggt atactccttc      240

gggggttact gctctggtga agactatgag acactgcgtc agatagatgt gcacattttc      300

aatgcagtgt ccttgcgttg gacaaagctg cccccggtga agtctgccat ccgtgggcaa      360

gctcctgtgg taccctacat gcgctatgga cactcaaccg tcctcatcga cgacacagtc      420

ctcctttggg gcgggcggaa tgacaccgaa ggggcctgca atgtgctcta tgcctttgac      480

gtcaatacgc acaagtggtt cacaccccga gtgtcaggga cagttcctgg ggcccgggat      540

ggacattcag cctgtgtcct aggcaagatc atgtacattt ttgggggcta cgagcagcag      600

gcggactgtt tttccaatga cattcacaag ctagatacca gcaccatgac atggactctt      660

atctgtacaa agggcagccc tgcacgctgg agggacttcc actcagccac aatgctggga      720

agtcacatgt atgtctttgg gggccgtgcc gaccgctttg ggccattcca ttccaacaat      780

gagatttact gcaaccgcat tcgagtcttt gacaccagaa ctgaggcttg gctggactgt      840

cccccgactc cagtgctgcc tgaggggcgc cggagccact cggcctttgg ctacaatggg      900

gagctgtaca tctttggtgg ttataatgca aggctgaacc ggcacttcca tgacctctgg      960

aagtttaatc ctgtgtcctt tacctggaaa aagattgaac cgaaggggaa ggggccatgt     1020

ccccgccggc gccagtgctg ctgtattgtt ggtgacaaga ttgtcctctt tgggggtacc     1080

agtccatctc ctgaggaagg cctgggagat gaatttgacc ttatagatca ttctgactta     1140

cacattttgg actttagccc tagtctgaag actctgtgca aactggccgt gattcagtat     1200

aacctagacc agtcctgttt gcctcatgat atcaggtggg agctgaatgc catgaccacc     1260

aacagcaata tcagtcgccc catcgtctcc tccccctttg cctatcccct cccctctgct     1320

tgagccttga gccttgactg ggagctgaaa ggagttgcag ctgttggcat gagacctcct     1380

tctccccgtc ttggggaggt ggggaccagc agataaatcc cacccttcct tgagctgtcg     1440

ctgtactctg aagttcagcc agctcagatt ttataaaaat taattaaaat ctcc           1494


<210> 2334
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 2334
aaaaggggcg gtggcggcgg cggcggcggc ggcggcggcg gcgacggcga gaaagagctt       60

gccggggggc gagcaggaca ggacgaagcc ggagtgtagg cggcagagga ttcgctccca      120

gagcagctgc ggccaggtat atgaatgacc taaaggtaca aataaagacg gagagagaac      180

agtgccaact gggagcaggg caagaatgcc aattcctcct cccccgccac ccccacctgg      240

tcctcctcca cctcccacat ttcatcaggc aaacacagag cagcccaagc tgagtagaga      300

tgagcagcgg ggtcgaggcg ccctcttaca ggacatttgc aaagggacca agctgaagaa      360

ggtgaccaac attaatgatc ggagtgctcc catcctcgag actcctccac ccccaccacc      420

tgtgatccga aatggtgcca gggatgctcc ccctccccca ccaccatacc gaatgcatgg      480

gtcagaaccc ccgagccgag gaaagccccc acctccaccc tcaaggacgc cagctgggcc      540

accccctcct cctccaccgc ccctgaggaa tggccacaga gattctatca ccactgtccg      600

gtctttcttg gatgattttg agtcaaagta ttccttccat ccagtagaag actttcctgc      660

tccagaagaa tataaacact ttcagaggat atatcccagc aaaacaaacc gagctgcccg      720

tggagcccca cctctgccac ccattctcag gtgaagcctg gcttggtccc gttcctcagg      780

aaaaggatgg accttctctt cttctcagat ggtcccttcc attcccctga aacctgcatg      840

agagctccta acatgtttct ccaatgcaat caagccctag actccaaatg tcctcccagc      900

tcacctccat ctatgcatct catctctgga tttggtgatc agactctata ttgacagtag      960

gatctcaaac cctgcatcca tccttcctcc agcaagccct gctagccaca tgaggaacaa     1020

gtttccgtgt cttctgcctt cctcttgggg aaaggtgcct tgttgtgatg aattaactca     1080

ctgttagggc agggtggaga atggtactcc ttccttctcc tgtccactgt gggggaagct     1140

tggcaggtat attatatttc atcatttagg aggctggcat gaccaggact tatgggtggg     1200

aggggagcat ttttagtgaa gcaagaaagg agtttgccaa gaagtgatct gttttaaagg     1260

tcatatttgg agaaagggca aggaattggg tctgctttat ttttgggggt attttgtttt     1320

tgttctcacc tgctgccccc ccaccccacc accccaggga taaattggat ataaacacta     1380

aatactaatc agttgaactt aacatttaat aaaaagaaag ggtgaaataa actgaagacc     1440

attttagaac tagtcagttc tctgcagcaa agggaacagg agccatttga accctctggg     1500

acccctcacc ccactgcttc agggtgctag gctgagggat gtttttcctc ccccttaccg     1560

cccatgccct tgaaagaaaa gtcacttttt gtggagggca tcattcattc ctgattcaca     1620

aaccccaaaa acctctggtg ggagatagga agatagggcg tgggcctggg ccttaacctc     1680

aatcttgtgt ctgcctcagt cttttctgac tggccctgaa gttgtcagtg gctctttctg     1740

tccttcagcc cctggaaggt gctccaggat aacaaagaag ggcaggttga agcccctcat     1800

ggaaggagct ggctttgtgg ggctgcaaag gacttttaag tcctgcctgt actgaagttc     1860

acagcccacc tgactgagca gactcttcct gttcctttct ctaccaccct tgccttccca     1920

ggactgcacg gtttaacaca gcagagtaca gaagggtgaa gaagtgagca gaggcttatg     1980

aagatattca gatactcttc tatgccagga agcacaaaga ctttgttgag atttgcctca     2040

gttcagtaga tcttccttgg cagccagcca taggttgttt ctttgtcttc cgggtcctaa     2100

agagcacaga gaaaatggag gtccccagtc taggtaggaa gctgattgga tgaggacttc     2160

tttttttccg acagcaggat ggggctcttg ggctccacac accagatgct ttggttttct     2220

acaactgttg ctatgtgtag agggtgctca gagcgtggca tgagagcaag gagaccatgg     2280

ctactctttg aaatggatgg ggaaaattag cttaaaaatt taatcacgag attgcgccac     2340

tgcactccag cctgggcgac agagccagac tccgtctc                             2378


<210> 2335
<211> 1259
<212> DNA
<213> Homo sapiens

<400> 2335
gacgcggtcc ccgccccacc gtagcgacgc cgcggtccgc cggatctcca gcgctcagtc       60

cgcgccgcag gtggtgcttg tctgcagagt catgacctct ttccgcttgg ccctcatcca      120

gcttcagatt tcttccatca aatcagataa cgtcactcgc gcttgtagct tcatccggga      180

ggcagcaacg caaggagcca aaatagtttc tttgccggaa tgctttaatt ctccatatgg      240

agcgaaatat tttcctgaat atgcagagaa aattcctggt gaatccacac agaagctttc      300

tgaagtagca aaggaatgca gcatatatct cattggaggc tctatccctg aagaggatgc      360

tgggaaatta tataacacct gtgctgtgtt tgggcctgat ggaactttac tagcaaagta      420

tagaaagatc catctgtttg acattgatgt tcctggaaaa attacatttc aagaatctaa      480

aacattgagt ccgggtgata gtttctccac atttgatact ccttactgca gagtgggtct      540

gggcatctgc tacgacatgc ggtttgcaga gcttgcacaa atctacgcac agagaggctg      600

ccagctgttg gtatatccag gagcttttaa tctgaccact ggaccagccc attgggagtt      660

acttcagcga agccgggctg ttgataatca ggtgtatgtg gccacagcct ctcctgcccg      720

ggatgacaaa gcctcctatg ttgcctgggg acacagcacc gtggtgaacc cttgggggga      780

ggttctagcc aaagctggca cagaagaagc aatcgtgtat tcagacatag acctgaagaa      840

gctggctgaa atacgccagc aaatccccgt ttttagacag aagcgatcag acctctatgc      900

tgtggagatg aaaaagccct aaagtttatg tttctaatgt gtcacagaat aggacgatat      960

gattctacaa cataatcaac tccctattaa attctttaat gaagattttt tttttaattc     1020

ggccttgtcc ttcctaggtt ctctattgag atgagaaagc ctcattatgc tgacattttc     1080

cacgccacat taaatagtta aaaaggatgc agcctggagc cagagagcag aaagctgggc     1140

tggttctgaa gcttcttcca tacttaagtt gcctccaagc agtttgtgaa agtatcagat     1200

cttggtatcc tggtgattga ttcacctaat ataaatatat ttgtgtcatg aacctctta      1259


<210> 2336
<211> 4528
<212> DNA
<213> Homo sapiens

<400> 2336
cggcgtccgg ccgcggccga cggtagttcg cttccccgag agtgcgcgga ggcccgggtg       60

cgaggagggc ctgtttctct tcagccctgg ttcattcacc tcgcggaccg agggccccgc      120

cgtcaggagc cggcgaccgt gccctggtgc gagctgtgat ggtcattgtc ctccagagca      180

gtgatggagg aaataccagc ccaggaagca gcagggtcac caagggtcca gtttcagtct      240

ttggagaccc agtctgagtg tctgtcccca gagcctcagt ttgtgcagga caccgacatg      300

gaacagggac tcactgggga tggagagacc agagaagaga acaagctgtt gattcctaag      360

cagaaaattt cggaagaagt gcattcatac aaagtgagag taggaagact caaacacgat      420

attacccaag ttcctgagac tagagaagtg tataagtctg aggacagatt agaaagactt      480

caggaaattc taaggaaatt tctgtacctg gagagagagt ttaggcaaat aacaatcagc      540

aaggaaacct tcaccagtga gaagaacaat gaatgtcatg aacccgaaaa aagcttcagt      600

ctggactcta ctattgatgc agatcagaga gttcttagaa tacagaatac cgatgacaat      660

gataagtatg acatgagctt caaccagaat tcagcctctg gtaaacatga acacttaaat      720

ctaacagagg attttcagag tagtgaatgt aaggaaagct taatggatct ctcccacctt      780

aataaatggg agagcatccc taacactgag aaatcctata aatgtgatgt atgtgggaaa      840

attttccatc agagctcagc ccttactaga catcagagaa tccatactag agagaagccc      900

tacaaatgta aagaatgtga aaagtctttc agtcagagct caagtcttag tcgacataaa      960

agaatacaca ctagagaaaa accttacaaa tgtgaagcat ctgataaatc ctgtgaagcg     1020

tctgataaat cctgtagtcc aagctcaggc ataattcagc ataagaaaat tcacaccaga     1080

gccaaatctt acaaatgtag cagttgtgaa agagtcttca gtcgtagtgt ccaccttact     1140

caacatcaga aaattcacaa agagatgccc tgtaagtgta ctgtatgtgg cagtgacttc     1200

tgccatactt catacctact tgaacatcag agggtccatc atgaagagaa agcctatgag     1260

tatgatgaat atgggttggc ctatattaaa caacaaggaa ttcatttcag agaaaagccc     1320

tatacgtgta gtgaatgtgg aaaagacttc agattgaatt cacatcttat tcagcatcaa     1380

agaattcaca caggagagaa agcacatgaa tgtaatgaat gtggaaaagc tttcagtcaa     1440

acctcatgcc ttattcagca tcacaaaatg cataggaaag agaaatcgta tgaatgtaat     1500

gagtatgagg gcagtttcag tcatagctca gatcttatcc tgcaacaaga agtcctcacc     1560

agacagaaag cctttgattg tgatgtatgg gaaaagaact ccagtcagag agcacatcta     1620

gttcaacatc agagcattca taccaaagag aactcatgaa tgtaatgaag atgggaagat     1680

atttatcaaa ttcaggcttc attcagcatc tgagagttca caccagggag aaatcatgta     1740

tgtactgcat gtggtaaagc cttcagtcat agctcagcca ttgctcagca tcagataatt     1800

cacaccagag agaaaccctc tgaatgtgac gaatgaagaa aaggtattag tgttaaactc     1860

ttaatcgact cctgcaaatc tataccagtg agaaatctta caaatgtatt gaatgtggca     1920

aatttttcat gctattagta ttttcatacc ttagtcacat ttggagaatt cacatgggaa     1980

taaaattcca ttgctgcaat gaatgtgaaa aagccatcag tcaaagaaac taccttgttt     2040

agtatcaaat tcacgccatg caaaaagatt ataaatgtaa taagcatgta tgtgtgtgag     2100

gagattcagt cataacccaa cgctcattca acatcaaaga atttatacct aagagaactt     2160

atttgggtgt agtaaatggc agatctttca ataggagttt aactagtctt tgtcatatca     2220

gaatatccat agtagacaag aatttgatgt aacgcaaatg gaaaaactcg acaccacatt     2280

tcaggcttta cccaacatcg aaataatgga gagaaaattg ttgattattt gtttatgaaa     2340

ttgttaatac atagtcccaa tctttttcat tgcacaaaaa tctagggttg acttggtaaa     2400

tgcagtgaca ttttctcatg gagttccttt atttaatatg tattctaagt aggtacgttt     2460

atttttactt ttttattata attttgatat taaaaagaac agagatgggg tcttgctttg     2520

ttgcccaggc tggtcttgaa ctcctggcct caagcgatcc tcccacctgt cctcccaaag     2580

tgctggggtt acaggcgtgt gtcactgtgc tgggcctatt ttatttatag aactcattta     2640

agctgttttt attttaatat gccctataaa catttttata ttttttgaaa ttggttctta     2700

gtgttcacaa cttccataag atactgctaa tgcaccagta ttaaaacaca tcgacgtaag     2760

tagctcattt agctttttct gctgttcttg gcccaagttc tttccaaaac caactcttag     2820

gcctgctctt tactagggat cttatgtcgt attgctttac agccacaaca cttggattcc     2880

tgttgattaa cttctccatt ctcttaagca cctttagaag atttagaagt ttcctagttt     2940

taagtgtttc accagcaagt attccatacc tacttgatgt tgctggtctg gtgtcttatt     3000

tcctaaagtg aagcatcttt ttttaaaaaa gaatttgatt gacaatatat ccagtccaat     3060

ataagtatga aggattctct ctcctgagat tgtagcaggc agccaaacat tttcaaatga     3120

tgcccaaggt tttagctgtc ttgtgtgcat ccacagtctg cgaagaagac atgataagga     3180

catcagggag ccaacaagac tcctaatagc ctcactacat tcatccagtg cctattctgc     3240

atgcctaagc ttagagttct tttatatacc tctacggcca gcaaaatgct caggtctgct     3300

cttggtaggg taaacataaa gaagatacac aggccgggca tggtggctca cacctgtaat     3360

cccagcactt tgggaggctg aggcggatgg atcacgaggt caggcagtcg agaccatcct     3420

ggccaacatg gtgaaacccc gtctctacta aaaatacaaa agttagccgg gtgtggtggc     3480

acgcgcctgt aatcccagct actcaggagg ctgaggcagg agaactgctt gaacctggga     3540

ggcggaggtt gcagtgagcc gagattgcac cactgcactc cagcctgggc gacagagcag     3600

gactctctct caaaaaaaca caaaaaaaca aaaacaaaaa accatacaca cacacacaca     3660

cacacaaatc agcatcataa gggaatgtag ccttccaaca gagatgatgc tgttcgtatg     3720

ttaatctcag agacagtatt tcaagagagt ggcaggtctg ttcctggtaa aattttaacc     3780

attaggattg cagataaatg tttgaattct gctcctctct catcaatcca ggacagtatt     3840

tgaagtgtga gggctttgtg tatagttgtt tatccattac cacatttttg tattttaata     3900

gtctacaggc tatataaaag aacatggctt tttgactgat aaaagtgatt acagatgttg     3960

gctcaagttc agggccacca tcatatacct aacaagagtt catgattctt taggtaatgt     4020

caaaacattt tgtatttttc catcttaagc tttataacat tttgtgagta agacaaatgt     4080

tatttaaaat tcttgttgtc agtccagcaa ttgaggcttt catagttcag tgttataata     4140

ttcagtaggg accctcaaca aatatataaa aatatgttgc tcactctata atcctcctat     4200

ggctaacctc taggatagtt ctgccactat attttacttc tttgccatca gcaagagtag     4260

gatttcatca aggcaaggta ggaatctaaa tgaaattgat atataaatga attgatctaa     4320

atgtaaaagc aaatgaaaaa tgcatgtgtt ttttcctgtc aaacatgtat acccttatgt     4380

atagagacca gtagtcacgt atggtgactg aaacaggatt atgtaatccc taaaaagcag     4440

aatatgtaaa aatcacatgt atgcgtttgg tttaggaatg tgcttttgta cttccacttg     4500

aataaaggtg tgtttggtat tctgagaa                                        4528


<210> 2337
<211> 1183
<212> DNA
<213> Homo sapiens

<400> 2337
agctttggga tctcaggagg aggagaaccc aagaaactgt ggaatgatgc actaagtgac       60

cgcttcagcg gtgagatccc cgatgaccag atggcgcaca gctccttttt tccagatgag      120

tatttcacct gctcctcctt gtgcctcagc tgtggggttg gatgtaagaa aagcatgaat      180

catgggaagg aaggagtgcc tcatgaagcc aagagccgct gcagatactc ccaccagtat      240

gacaaccgag tgtatacctg caaggcctgc tatgagagag gcgaggaagt cagtgtagtg      300

cccaaaacat ctgcttccac tgactccccc tggatgggtc tcgcaaaata tgcctggtct      360

gggtatgtga tcgaatgtcc taactgtggc gtggtctatc gtagtcggca gtactggttt      420

ggaaaccaag atcctgtgga tacggtggtg cggacagaga ttgtgcatgt gtggcctgga      480

actgatgggt ttctgaagga caacaacaat gctgcccagc gcctgttgga cgggatgaac      540

ttcatggctc agtcggtgtc cgagcttagc cttggaccca ccaaggctgt gacttcctgg      600

ctgacagacc agatcgcccc tgcctactgg aggcccaact cccagattct gagctgcaac      660

aagtgtgcga cgtcctttaa agataacgac actaagcatc actgccgagc ctgtggggag      720

ggcttctgtg acagctgttc atcaaagact cggccagtgc ctgagcgggg ctggggccct      780

gcgccagtgc gggtctgtga caactgctac gaagccagga acgtccagtt agctgttacc      840

gaggcacaag tggacgatga aggtggaacg ctcattgctc ggaaggtggg cgaggccgtg      900

cagaacactc tgggagccgt ggtgacagcc attgacatac cactaggtct ggtaaaggac      960

gcggccaggc ctgcgtactg ggtgcctgac cacgaaatcc tccactgcca caactgccgg     1020

aaggagttca gcatcaagct ctccaagcac cactgccggg cctgcggaca gggcttctgt     1080

gatgagtgct cccatgaccg ccgggctgtt ccttctcgtg gctgggacca tcccgtccga     1140

gtctgcttca actgcaataa aaagcccggt gacctttaac ccc                       1183


<210> 2338
<211> 1006
<212> DNA
<213> Homo sapiens

<400> 2338
cattagagta aatgaagcca tgaagtccag cggacaccgg gagtggggag tggggaagcc       60

cggcactccg ggagaccggg ccagggaagg agggtctgga ccggacccag cccctgcccg      120

gggagcgagc tccggagctg ccctacgagg tcaaaacgta gcagtggcgg agacccgcag      180

ggggcgcccg aacgccaccc tcggcccctc cccgctccag aggccccgcc ccgtcacgtg      240

cccgcggttc gcgtcacacc cggaagcagg ggcccgagcg gagccggccg cgatgagcgg      300

ggagccgggg cagacgtccg tagcgccccc tcccgaggag gtcgagccgg gcagtggggt      360

ccgcatcgtg gtggagtact gtgaaccctg cggcttcgag gcgacctacc tggagctggc      420

cagtgctgtg aaggagcagt atccgggcat cgagatcgag tcgcgcctcg ggggcacagg      480

tgcctttgag atagagataa atggacagct ggtgttctcc aagctggaga atgggggctt      540

tccctatgag aaagatctca ttgaggccat ccgaagagcc agtaatggag aaaccctaga      600

aaagatcacc aacagccgtc ctccctgcgt catcctgtga ctgcacagga ctctgggttc      660

ctgctctgtt ctggggtcca aaccttggtc tccctttggt cctgctggga gctccccctg      720

cctctttccc ctacttagct ccttagcaaa gagaccctgg cctccacttt gccctttggg      780

tacaaagaag gaatagaaga ttccgtggcc ttgggggcag gagagagaca ctctccatga      840

acacttctcc agccacctca tacccccttc ccagggtaag tgcccacgaa agcccagtcc      900

actcttcgcc tcggtaatac ctgtctgatg ccacagattt tatttattct cccctaaccc      960

agggcaatgt cagctattgg cagtaaagtg gcgctacaaa cactaa                    1006


<210> 2339
<211> 1419
<212> DNA
<213> Homo sapiens

<400> 2339
ttttcatttc tcacaaggac tgggtgaaga gttctgcagc cttacagaga ctggaaaaga       60

agcccaaacc aaggccccca gagaggtccc ccaggcccct ttgggtccct gagcctcagc      120

tggagatccg gcgcaggaga ccaacgcctg ccatgctgtt ccggctctca gagcactcct      180

caccagagga ggaagcctcc ccccaccaga gagcctcagg agaggggcac catctcaagt      240

cgaagagacc caacccctgt gcctacacac caccttcgct gaaagctgtg cagcgcattg      300

ctgagtctca cctgcagtct atcagcaatt tgaatgagaa ccaggcctca gaggaggagg      360

atgagctggg ggagcttcgg gagctgggtt atccaagaga ggaagatgag gaggaagagg      420

aggatgatga agaagaggaa gaagaagagg acagccaggc tgaagtcctg aaggtcatca      480

ggcagtctgc tgggcaaaag acaacctgtg gccagggtct ggaagggccc tgggagcgcc      540

caccccctct ggatgagtcc gagagagatg gaggctctga ggaccaagtg gaagacccag      600

cactaagtga gcctggggag gaacctcagc gcccttcccc ctctgagcct ggcacatagg      660

cacccagcct gcatctccca ggaggaagtg gaggggacat cgctgttccc cagaaaccca      720

ctctatcctc accctgtttt gtgctcttcc cctcgcctgc tagggctgcg gcttctgact      780

tctagaagac taaggctggt ctgtgtttgc ttgtttgccc acctttggct gatacccaga      840

gaacctgggc acttgctgcc tgatgcccac ccctgccagt cattcctcca ttcacccagc      900

gggaggtggg atgtgagaca gcccacattg gaaaatccag aaaaccggga acagggattt      960

gcccttcaca attctactcc ccagatcctc tcccctggac acaggagacc cacagggcag     1020

gaccctaaga tctggggaaa ggaggtcctg agaaccttga ggtaccctta gatccttttc     1080

tacccacttt cctatggagg attccaagtc accacttctc tcaccggctt ctaccagggt     1140

ccaggactaa ggcgtttttc tccatagcct caacattttg ggaatcttcc cttaatcacc     1200

cttgctcctc ctgggtgcct ggaagatgga ctggcagaga cctctttgtt gcgttttgtg     1260

ctttgatgcc aggaatgccg cctagtttat gtccccggtg gggcacacag cggggggcgc     1320

caggttttcc ttgtccccca gctgctctgc ccctttcccc ttcttccctg actccaggcc     1380

tgaacccctc ccgtgctgta ataaatcttt gtaaataac                            1419


<210> 2340
<211> 1504
<212> DNA
<213> Homo sapiens

<400> 2340
ttttcatttc tcacaaggac tgggtgaaga gttctgcagc cttacagaga ctggaaaaga       60

agcccaaacc aaggccccca gagaggtccc ccaggcccct ttgggtccct gagcctcagc      120

tggaggtggg gggtgcctgc agtgcgctgg ctcagtctcc ttctgaaaag ctggatccag      180

cttgtttgaa gcccttgagc tgatcttaga tccggcgcag gagaccaacg cctgccatgc      240

tgttccggct ctcagagcac tcctcaccag aggaggaagc ctccccccac cagagagcct      300

caggagaggg gcaccatctc aagtcgaaga gacccaaccc ctgtgcctac acaccacctt      360

cgctgaaagc tgtgcagcgc attgctgagt ctcacctgca gtctatcagc aatttgaatg      420

agaaccaggc ctcagaggag gaggatgagc tgggggagct tcgggagctg ggttatccaa      480

gagaggaaga tgaggaggaa gaggaggatg atgaagaaga ggaagaagaa gaggacagcc      540

aggctgaagt cctgaaggtc atcaggcagt ctgctgggca aaagacaacc tgtggccagg      600

gtctggaagg gccctgggag cgcccacccc ctctggatga gtccgagaga gatggaggct      660

ctgaggacca agtggaagac ccagcactaa gtgagcctgg ggaggaacct cagcgccctt      720

ccccctctga gcctggcaca taggcaccca gcctgcatct cccaggagga agtggagggg      780

acatcgctgt tccccagaaa cccactctat cctcaccctg ttttgtgctc ttcccctcgc      840

ctgctagggc tgcggcttct gacttctaga agactaaggc tggtctgtgt ttgcttgttt      900

gcccaccttt ggctgatacc cagagaacct gggcacttgc tgcctgatgc ccacccctgc      960

cagtcattcc tccattcacc cagcgggagg tgggatgtga gacagcccac attggaaaat     1020

ccagaaaacc gggaacaggg atttgccctt cacaattcta ctccccagat cctctcccct     1080

ggacacagga gacccacagg gcaggaccct aagatctggg gaaaggaggt cctgagaacc     1140

ttgaggtacc cttagatcct tttctaccca ctttcctatg gaggattcca agtcaccact     1200

tctctcaccg gcttctacca gggtccagga ctaaggcgtt tttctccata gcctcaacat     1260

tttgggaatc ttcccttaat cacccttgct cctcctgggt gcctggaaga tggactggca     1320

gagacctctt tgttgcgttt tgtgctttga tgccaggaat gccgcctagt ttatgtcccc     1380

ggtggggcac acagcggggg gcgccaggtt ttccttgtcc cccagctgct ctgccccttt     1440

ccccttcttc cctgactcca ggcctgaacc cctcccgtgc tgtaataaat ctttgtaaat     1500

aact                                                                  1504


<210> 2341
<211> 1779
<212> DNA
<213> Homo sapiens

<400> 2341
gggaggtgga gaaggacggg agaggcagag agaggagaca cgcagagaca ctcaggaggg       60

gagagacacc gagacgcaga gacactcagg aggggagaga caccgagacg cagagacacc      120

caggccgggg agcgcgaggg agcgaggcac agacctggct cagcgagcgc ggggggcgag      180

ccccgagtcc cgagagcctg ggggcgcgcc cagcccgggc gccgaccctc ctcccgctcc      240

cgcgccctcc cctcggcggg cacggtattt ttatccgtgc gcgaacagcc ctcctcctcc      300

tctcgccgca cagcccgccg cctgcgcggg ggagcccagc acagaccgcc gccgggaccc      360

cgagtcgcgc accccagccc caccgcccac cccgcgcgcc atggacccca aggaccgcaa      420

gaagatccag ttctcggtgc ccgcgccccc tagccagctc gacccccgcc aggtggagat      480

gatccggcgc aggagaccaa cgcctgccat gctgttccgg ctctcagagc actcctcacc      540

agaggaggaa gcctcccccc accaggtgac ccctttaacc tggcacttcc cctggcagag      600

agcctcagga gaggggcacc atctcaagtc gaagagaccc aacccctgtg cctacacacc      660

accttcgctg aaagctgtgc agcgcattgc tgagtctcac ctgcagtcta tcagcaattt      720

gaatgagaac caggcctcag aggaggagga tgagctgggg gagcttcggg agctgggtta      780

tccaagagag gaagatgagg aggaagagga ggatgatgaa gaagaggaag aagaagagga      840

cagccaggct gaagtcctga aggtcatcag gcagtctgct gggcaaaaga caacctgtgg      900

ccagggtctg gaagggccct gggagcgccc accccctctg gatgagtccg agagagatgg      960

aggctctgag gaccaagtgg aagacccagc actaagtgag cctggggagg aacctcagcg     1020

cccttccccc tctgagcctg gcacataggc acccagcctg catctcccag gaggaagtgg     1080

aggggacatc gctgttcccc agaaacccac tctatcctca ccctgttttg tgctcttccc     1140

ctcgcctgct agggctgcgg cttctgactt ctagaagact aaggctggtc tgtgtttgct     1200

tgtttgccca cctttggctg atacccagag aacctgggca cttgctgcct gatgcccacc     1260

cctgccagtc attcctccat tcacccagcg ggaggtggga tgtgagacag cccacattgg     1320

aaaatccaga aaaccgggaa cagggatttg cccttcacaa ttctactccc cagatcctct     1380

cccctggaca caggagaccc acagggcagg accctaagat ctggggaaag gaggtcctga     1440

gaaccttgag gtacccttag atccttttct acccactttc ctatggagga ttccaagtca     1500

ccacttctct caccggcttc taccagggtc caggactaag gcgtttttct ccatagcctc     1560

aacattttgg gaatcttccc ttaatcaccc ttgctcctcc tgggtgcctg gaagatggac     1620

tggcagagac ctctttgttg cgttttgtgc tttgatgcca ggaatgccgc ctagtttatg     1680

tccccggtgg ggcacacagc ggggggcgcc aggttttcct tgtcccccag ctgctctgcc     1740

cctttcccct tcttccctga ctccaggcct gaacccctc                            1779


<210> 2342
<211> 5241
<212> DNA
<213> Homo sapiens

<400> 2342
attgtttgaa tttgaaaacg gtaacatcgc agtgctgctc gcgggtctgg ctagtcaggc       60

gaagtttgca gaatggaatc taattttaat caagagggag tacctcgacc atcttatgtt      120

tttagtgctg acccaattgc aaggccttca gaaataaatt tcgatggcat taagcttgat      180

ctgtctcatg aattttcctt agttgctcca aatactgagg caaacagttt cgaatctaaa      240

gattatctcc aggtttgtct tcgaataaga ccatttacac agtcagaaaa agaacttgag      300

tctgagggct gtgtgcatat tctggattca cagactgttg tgctgaaaga gcctcaatgc      360

atccttggtc ggttaagtga aaaaagctca gggcagatgg cacagaaatt cagtttttcc      420

aaggtttttg gcccagcaac tacacagaag gaattctttc agggttgcat tatgcaacca      480

gtaaaagacc tcttgaaagg acagagtcgt ctgattttta cttacgggct aaccaattca      540

ggaaaaacat atacatttca agggacagaa gaaaatattg gcattctgcc tcgaactttg      600

aatgtattat ttgatagtct tcaagaaaga ctgtatacaa agatgaacct taaaccacat      660

agatccagag aatacttaag gttatcatca gaacaagaga aagaagaaat tgctagcaaa      720

agtgcattgc ttcggcaaat taaagaggtt actgtgcata atgatagtga tgatactctt      780

tatggaagtt taactaactc tttgaatatc tcagagtttg aagaatccat aaaagattat      840

gaacaagcca acttgaatat ggctaatagt ataaaatttt ctgtgtgggt ttctttcttt      900

gaaatttaca atgaatatat ttatgactta tttgttcctg tatcatctaa attccaaaag      960

agaaagatgc tgcgcctttc ccaagacgta aagggctatt cttttataaa agatctacaa     1020

tggattcaag tatctgattc caaagaagcc tatagacttt taaaactagg aataaagcac     1080

cagagtgttg ccttcacaaa attgaataat gcttccagta gaagtcacag catattcact     1140

gttaaaatat tacagattga agattctgaa atgtctcgtg taattcgagt cagtgaatta     1200

tctttatgtg atcttgctgg ttcagaacga actatgaaga cacagaatga aggtgaaagg     1260

ttaagagaga ctgggaatat caacacttct ttattgactc tgggaaagtg tattaacgtc     1320

ttgaagaata gtgaaaagtc aaagtttcaa cagcatgtgc ctttccggga aagtaaactg     1380

actcactatt ttcaaagttt ttttaatggt aaagggaaaa tttgtatgat tgtcaatatc     1440

agccaatgtt atttagccta tgatgaaaca ctcaatgtat tgaagttctc cgccattgca     1500

caaaaagttt gtgtcccaga cactttaaat tcctctcaag agaaattatt tggacctgtc     1560

aaatcttctc aagatgtatc actagacagt aattcaaaca gtaaaatatt aaatgtaaaa     1620

agagccacca tttcatggga aaatagtcta gaagatttga tggaagacga ggatttggtt     1680

gaggagctag aaaacgctga agaaactcaa aatgtggaaa ctaaacttct tgatgaagat     1740

ctagataaaa cattagagga aaataaggct ttcattagcc acgaggagaa aagaaaactg     1800

ttggacttaa tagaagactt gaaaaaaaaa ctgataaatg aaaaaaagga aaaattaacc     1860

ttggaattta aaattcgaga agaagttaca caggagttta ctcagtattg ggctcaacgg     1920

gaagctgact ttaaggagac tctgcttcaa gaacgagaga tattagaaga aaatgctgaa     1980

cgtcgtttgg ctatcttcaa ggatttggtt ggtaaatgtg acactcgaga agaagcagcg     2040

aaagacattt gtgccacaaa agttgaaact gaagaaacac ataattatgt aggatttgaa     2100

gatattattg attctcttca agataatgtt gctgatatta agaaacaggc tgaaattgct     2160

cacttatata ttgcatctct tcctgacccc caggaagcta ctgcttgttt agaactaaag     2220

tttaatcaaa ttaaagctga attagctaaa accaaaggag aattaatcaa aaccaaagaa     2280

gagttaaaaa agagagaaaa tgaatcagat tcattgattc aagagcttga gacatctaat     2340

aagaaaataa ttacacagaa tcaaagaatt aaagaattga taaatataat tgatcaaaaa     2400

gaagatacta tcaacgaatt tcagaaccta aagtctcata tggaaaacac atttaaatgc     2460

aatgacaagg ctgatacatc ttctttaata ataaacaata aattgatttg taatgaaaca     2520

gttgaagtac ctaaggacag caaatctaaa atctgttcag aaagaaaaag agtaaatgaa     2580

aatgaacttc agcaagatga accaccagca aagaaagggt ctatccatgt tagttcagct     2640

atcactgaag accaaaagaa aagtgaagaa gtgcgaccga acattgcaga aattgaagac     2700

atcagagttt tacaagaaaa taatgaagga ctgagagcat ttttactcac tattgagaat     2760

gaacttaaaa atgaaaagga agaaaaagca gaattaaata aacagattgt tcattttcag     2820

caggaacttt ctctttctga aaaaaagaat ttaactttaa gtaaagaggt ccaacaaatt     2880

cagtcaaatt atgatattgc aattgctgaa ttacatgtgc agaaaagtaa aaatcaagaa     2940

caggaggaaa agatcatgaa attgtcaaat gagatagaaa ctgctacaag aagcattaca     3000

aataatgttt cacaaataaa attaatgcac acgaaaatag acgaactacg tactcttgat     3060

tcagtttctc agatttcaaa catagatttg ctcaatctca gggatctgtc aaatggttct     3120

gaggaggata atttgccaaa tacacagtta gaccttttag gtaatgatta tttggtaagt     3180

aagcaagtta aagaatatcg aattcaagaa cccaataggg aaaattcttt ccactctagt     3240

attgaagcta tttgggaaga atgtaaagag attgtgaagg cctcttccaa aaaaagtcat     3300

cagattgagg aactggaaca acaaattgaa aaattgcagg cagaagtaaa aggctataag     3360

gatgaaaaca atagactaaa ggagaaggag cataaaaacc aagatgacct actaaaagaa     3420

aaagaaactc ttatacagca gctgaaagaa gaattgcaag aaaaaaatgt tactcttgat     3480

gttcaaatac agcatgtagt tgaaggaaag agagcgcttt cagaacttac acaaggtgtt     3540

acttgctata aggcaaaaat aaaggaactt gaaacaattt tagagactca gaaagttgaa     3600

tgtagtcatt cagccaagtt agaacaagac attttggaaa aggaatctat catcttaaag     3660

ctagaaagaa atttgaagga atttcaagaa catcttcagg attctgtcaa aaacaccaaa     3720

gatttaaatg taaaggaact caagctgaaa gaagaaatca cacagttaac aaataatttg     3780

caagatatga aacatttact tcaattaaaa gaagaagaag aagaaaccaa caggcaagaa     3840

acagaaaaat tgaaagagga actctctgca agctctgctc gtacccagaa tctgaaagca     3900

gatcttcaga ggaaggaaga agattatgct gacctgaaag agaaactgac tgatgccaaa     3960

aagcagatta agcaagtaca gaaagaggta tctgtaatgc gtgatgagga taaattactg     4020

aggattaaaa ttaatgaact ggagaaaaag aaaaaccagt gttctcagga attagatatg     4080

aaacagcgaa ccattcagca actcaaggag cagttaaata atcagaaagt ggaagaagct     4140

atacaacagt atgagagagc atgcaaagat ctaaatgtta aagagaaaat aattgaagac     4200

atgcgaatga cactagaaga acaggaacaa actcaggtag aacaggatca agtgcttgag     4260

gctaaattag aggaagttga aaggctggcc acagaattgg aaaaatggaa ggaaaaatgc     4320

aatgatttgg aaaccaaaaa caatcaaagg tcaaataaag aacatgagaa caacacagat     4380

gtgcttggaa agctcactaa tcttcaagat gagttacagg agtctgaaca gaaatataat     4440

gctgatagaa agaaatggtt agaagaaaaa atgatgctta tcactcaagc gaaagaagca     4500

gagaatatac gaaataaaga gatgaaaaaa tatgctgagg acagggagcg tttttttaag     4560

caacagaatg aaatggaaat actgacagcc cagctgacag agaaagatag tgaccttcaa     4620

aagtggcgag aagaacgaga tcaactggtt gcagctttag aaatacagct aaaagcactg     4680

atatccagta atgtacagaa agataatgaa attgaacaac taaaaaggat catatcagag     4740

acttctaaaa tagaaacaca aatcatggat atcaagccca aacgtattag ttcagcagat     4800

cctgacaaac ttcaaactga acctctatcg acaagttttg aaatttccag aaataaaata     4860

gaggatggat ctgtagtcct tgactcttgt gaagtgtcaa cagaaaatga tcaaagcact     4920

cgatttccaa aacctgagtt agagattcaa tttacacctt tacagccaaa caaaatggca     4980

gtgaaacacc ctggttgtac cacaccagtg acagttaaga ttcccaaggc tcggaagagg     5040

aagagtaatg aaatggagga gagcgcctct cctcctccaa aggaatgcag ttcctcacca     5100

gcaatggaac aaagctggaa ggagaatgac tttgacaaat tgagagaaga aggcttcaga     5160

cgatcaaact actccgagct acaggaggaa attcaaacca aaggcaaaga agttgaaaac     5220

tttgaaaaaa atttagacta a                                               5241


<210> 2343
<211> 10274
<212> DNA
<213> Homo sapiens

<400> 2343
gggttgaagt tgaggctgag gagagagccg agctagcgac gagcagtcgt tgcggccgcc       60

ggcgccgcgg gaggtggtgg aggcctagcc ggagccgaga ggtctcttgt tcccgtccca      120

cggtcccggc gtcacccctc cggcgcccag tccccgtccc ggaactcccg ggcctgtcct      180

gggcccccgg tctgtgcact ccgctcgccg cagcgcccgg cccgggccgc acccgccggc      240

cccatgagga gggacgtgaa cggagtgacc aagagcaggt ttgagatgtt ctcaaatagt      300

gatgaagctg taatcaataa aaaacttccc aaagaactcc tgttacggat attttctttt      360

ctagatgttg ttaccctgtg ccgctgtgct caggtctcca gggcctggaa tgttctggct      420

ctggatggca gtaactggca gcgaattgac ctatttgatt tccagaggga tattgagggc      480

cgagtagtgg agaatatttc aaaacgatgt gggggctttt tacgaaagtt aagtcttcgt      540

ggatgtcttg gagtgggaga caatgcatta agaacctttg cacaaaactg caggaacatt      600

gaagtactga atctaaatgg gtgtacaaag acaacagacg ctgagggatg tccactgttg      660

gagcagttga acatttcctg gtgtgaccaa gtaaccaagg atggcattca agcactagtg      720

aggggctgtg ggggtctcaa ggccttattc ttaaaaggct gcacgcagct agaagatgaa      780

gctctcaagt acataggtgc acactgccct gaactggtga ctttgaactt gcagacttgc      840

ttgcaaatca cagatgaagg tctcattact atatgcagag ggtgccataa gttacaatcc      900

ctttgtgcct ctggctgctc caacatcaca gatgccatcc tgaatgctct aggtcagaac      960

tgcccacggc ttagaatatt ggaagtggca agatgttctc aattaacaga tgtgggcttt     1020

accactctag ccaggaattg ccatgaactt gaaaagatgg acctggaaga gtgtgttcag     1080

ataacagata gcacattaat ccaactttct atacactgtc ctcgacttca agtattgagt     1140

ctgtctcact gtgagctgat cacagatgat ggaattcgtc acctggggaa tggggcctgc     1200

gcccatgacc agctggaggt gattgagctg gacaactgcc cactaatcac agatgcatcc     1260

ctggagcact tgaagagctg tcatagcctt gagcggatag aactctatga ctgccagcaa     1320

atcacacggg ctggaatcaa gagactcagg acccatttac ccaatattaa agtccacgcc     1380

tacttcgcac ctgtcactcc acccccatca gtagggggca gcagacagcg cttctgcaga     1440

tgctgcatca tcctatgaca atggaggtgg tcaaccttgg cgaactgagt atttaatgac     1500

acttctagag ctaccgtgga gtctctccag tggaagcaac cccagtgttc tgagcaaggg     1560

ttacaaagtg agggagggca gtgtccagat ccccagagcc acacatacat acacatacac     1620

acccttaccc ccatccactc tagctttgtg accatgggac tgaagtttgt gatggctttt     1680

ttatcaagta gattggtaaa atttaaccat tcctgttgag gtgcccataa gaaaatcata     1740

ggccaagata gggaggggca ttccagcaaa ccccgtgtta atgctactgt ggtttttaaa     1800

tttttgtcta ggggtttctt tggggatttt agaacagcat ctgctgtcct ccggggtcaa     1860

gaaaagcatg gaaagacaat atatgatgta cccagggacc agaaagaaaa tttctttgca     1920

tcttagaaat ggtagacatt cattgtgact aaagagcttc tatgcttcct tgtttccatg     1980

ccaacatgct gagcatgctc acaaagaagg ctcgtccatt cctcctgtgt tttagtattt     2040

ggcccagagg tttcctaaat ggttgccttg aaatcactgt ggtccaaatg taattcttac     2100

acactcaaat tatcactgtc tgtagcacac ttgtgcacct gtcttacatt ctctgttgct     2160

cccccccaca ctcttgctca gtctgtcacc tgttcagtct gcttactcac tcaattgtta     2220

cccttttgct gttgtcgtgt ttacagtttg cattttgaat gattagttgg gattaccaaa     2280

cattttttaa aaagatatta tcaataaata tttttttaat tctaaatttt accattaggg     2340

gaccctgcct gaatctttgc caacctgcaa ggaaactcta atgaaagcaa gaaaagttat     2400

gagaagaaac tgttttgatg aaaacagatg ctaccttttg gtttctattt tatcttctga     2460

tatgtgataa ttcgcatggt atccccaata ttccccctac atattcttcc ttctgtcaga     2520

ctccaccaac tgtatcataa ggaaagagag agatgtatta ttaggaaaga gtgaaaatga     2580

taaatcacaa aacagagcct gaaagtcccc aacacccaag ttcagacatt aatgattaat     2640

gttattatat atttactgaa atctaggagt gatcagtggc atctctgacc tatgaggttg     2700

ttttaacagg aatgccacta gaggagctgt gtattctagc cagtctgttt ctctcttttc     2760

ccccatttca gcctttcagg gatacaagaa tggctctata acagctggtc aattgtatgt     2820

cagtgttaat ggattcatat ctagtgttgg caccccaaag ggccagaacc ttcccataac     2880

ctgtcagtca tctctctttt ctgccccagt cttttttttt tttttttttt ttttttaaga     2940

cgggttctca ctcttgccca gactggagtg cagtggtgcg atctcggctc accgcaacct     3000

ccacttccca ggctcaagcg attctcttgc ctcagcctac cgagtagctg ggattacagg     3060

catgcaccac tactgcctgg ctaatttttg tatttttagt agagatgggg tttcacatgt     3120

tggccagcct ggtcttgaac tcctgacctc aaatgatcca cctgcctcag cctcccaaag     3180

tgctgggact acaggcatga gccaccatgc ccggccctgt tcagacttct gaatgaagta     3240

tgaatgtagc caggtgaagc attgaggcag ctgaaagaga acactgagag gaagtaaggg     3300

gtttagtgtc tctgcttagc ctgggcacta gaactgaggg aggaatttag tgtccaggac     3360

tcaagagtcc aagaagaagc accctctgtc ttcccaaaaa atcagaggat aaaggaagta     3420

aaatgagttt ttaaagcata agaagaaaat ttctaaaccc caagattaga aacccagtgt     3480

gatttttagt agggtgattt tggcgggggg tgtcctttga gacattaatg tgcaatccat     3540

cataatatta atcttctata tgatccagac tattaaaagg cttgttttat ttatttattt     3600

tattttattt tattttttta gagatggggt ctcgctatct tgcccagcct ggactcaaac     3660

tcctgggctc aagccttcct cccacctcag cctcccaagt agctgggact acaggtgtgt     3720

gccactgtac ccagcttaag aggtttgttt taatgctgca gttgctgatt ataccagcat     3780

atataagaat aaagtctgat ttatttatcc attgatttag aaggcaattg gatgaaaggg     3840

tcttagaagt ctatactatc cattaatatt tatcatatta aatttatttt aaatcctgtt     3900

ttattgtgcc gctttaaaaa cgcagattac ttgtttattc attccccttt ccccttattc     3960

tctttcagat taccttataa ggaatatagt ttttaacatg aaactcagtt tcttgtctgt     4020

acccctacac ataaaaatac atacgtgcat acacacatac ttccagatgt ggttaataat     4080

attcagatcc ctaggttact caaacaaaac taaaggagag aactatttag gggccatctg     4140

ctttaaagtt taaggtgttt tgttgttgtt ttagtgcctg tacaaattga ccataaaacc     4200

cagattgatt agtgagtgtg gatttgagtt gcctaagttg aggctattaa ggtacttctt     4260

tacttaaaag ataagtttaa aagactctat tcatcagttc atgatgatct tggaaatgct     4320

gtttctctgc tcaaaggata tacccacagg caggtccatg gggacttgct ctggtgatct     4380

ctgctattaa ggcaaattcc agcctgtttg tgccaagaac agagtcaagt gagagagaat     4440

gaagactcag agatgtgcag cactggcttg tatgttgtca ggcagaagcc ttgttccttt     4500

ctcaagaaaa cttcaggcct atcaagcttg gaaggaaata cattttttta tgctgatttg     4560

cagcctacac cagctgatga atatgctagg actttgagag aacacaaagc atggtaagtt     4620

ttggtcaggt ggaaaggagc ctgacatctg aacataatgc ttcctctctc aacatctggg     4680

atacttttga aaattcagta aggcttaatg taggaaaaat tctttacagg aaaagctaat     4740

tgatctgttt gtctaacctc atagccactc caaaatatgc cttttataat ggaaaaaaac     4800

agtgaacaga gagaagagat ttggggataa gttagaaggt accctcaaaa ctactgccgt     4860

aaacctacag gtgggcaagg aggaattact gtagtgtctc tggagaaagt tcttgaacat     4920

ccaaatcatc tcttttctaa gcagtttttc ccctaatctc ataccttaca tcttccagca     4980

tcatttgcta catcaatgtc ttttcatcct cttcatcagc cccattgagc tgactccagc     5040

ttatttttgc actgatttcc accatttcct tcccacaccc atcctttccc tctatttaaa     5100

gcctccatct caccctcagt aatgctgctg atttactctc agatgtctca agtctagctt     5160

cctttttgaa tccttctcct actccagggg ctgtcaaagg cagccttaaa gttcagtgac     5220

tgttaggtgg ctcaggccat ttttcattgg gtggtctttg gtgtttgcat actgaatttg     5280

aattcagttt aaaagcaaac tgttggatat gaggaagaaa gggatatggc cttagccctt     5340

tttccaatat ttggaatatg aaagcatatt gtgctttgtg taaaaaatgt tttcttctcc     5400

tattctgctc ttgtctttac tgaaggtaaa agtattcctt aagtagcttt tgcaaatttc     5460

tagtctgatt tccacattca ttaagttgat ttagcagaca tgtaagtcag aagtttcaca     5520

tatcccttgt atcaaacatt ttatagggaa acctagtaaa tttatgatgc ttcattttgg     5580

gctttccaga ctatttgagt tattcaagat agccataatg ttttagtagc gacattcttt     5640

tattacttct aattgccttg taaaatgcat tgttatggcc cggcacggtg ggtggatcac     5700

aaggtcagga gttcaagaac agcctggcca agatggtgaa atgctgtctc tactgaaaat     5760

acaaaaatta gccaggtgtg gtggcaggtg cctgtaatcc cagctactcg ggaggctgag     5820

gcagagaatt gcttgaaccc gggaggtgga ggttgcagtg agctgagatc gcaccactgc     5880

actccaccct gggcgacaga gtgagactat ctcaaaaaaa aagaaagaaa gaaagaaaaa     5940

aatgcatcgt tactagtttg atagcccact aatgccatgg gggactaaac aaaatatgtg     6000

atgaaacctg tcttggtttg aagttgttag aaagtgtgag agtgtcactg gaaagaagag     6060

agtggcttcc tgcctgcttg tttagtcagc atgtccttag gtgactgtgt tgttgggaga     6120

agagcactca tgggtcatgg gtgacccttg gccattttat gtttattgtg ctgaaagtca     6180

caggcggctc atgccagttg ctaccagtga gaggaggggt ttaaaggaaa ttgctctatt     6240

ttgccttatt cctccttatg tgtatgattt aagggtaggc ttttatcctg gttgtatctc     6300

ctggctgaca gactttctca atcatatgtt tgagctctga agcattttac aaaaagattg     6360

cctctctatc tgcctgccaa tcctagaatc tttagccacc tcaaacccag gcactgtgaa     6420

ttagccaagt cctgtttgag aagaaatgta ggatgtttgg ttggaattct tgagacagaa     6480

cctctctccc cattaatgat gttgtaccaa agaattctaa agcagtaaaa ggataatggg     6540

gaaaaatgga gtcacagcct ttcctcgcct atatttcttt tttttttttt tttttttgac     6600

atggagtctc gctctgtcac ccaggttgga gtgccatggc acaatctcag ttcactgcaa     6660

cctctgcctc ctgggttcaa gtgattcttc tgtttcagcc tcccaagagg ccaggattac     6720

aggtgcccac caccacgccc agctaatgtt tgtatttttc atagagatgg ggttttgcca     6780

tgttggccag gctagtctcg aacttctgac ctcaagtggt ccacctgcct tggcctccca     6840

aagtgctggg attacaggtg taagccaccg cacctggcca gtttctatca taaattttaa     6900

atgtaagatt ggaagataca gagagctgta taaaatcata ccagtagggt ataattagcc     6960

caggtagttt aggaataaaa ttgggttgta tccgagtgcc ctaacttgac attttgattc     7020

tccagcaaag aacataggtt actaggttac taaccttgcc ttctcacttg ggataaactt     7080

tttttttttt tcttgttgcc caggctggag tgcaatagtg agatctcggc tcaccgcaac     7140

ctccgcctct tgggttcaag cgattctcct cccttagcct cccgagtagc tggaattaca     7200

gcctgtgcca ccacgcccgg caaaatttgt atttttagta gagacggggt ttcaccatgt     7260

tggtcaggct ggtttcaaac tcccaacctc aggtgatctg cccacctcag cctcccaaca     7320

tgctaggatt acaggcgtga gccactgcgc ccagcccagg ataaacattc tacctgcctg     7380

aaagtaccat aagaggcaag tgagtttctt gcatgatggg cttctgcagc ttccccctca     7440

agtcacatct acctgttgta tttatttatt tatttatttt tgagacagag tctcgctctg     7500

tttcccaggc tggagtgcag tggcgtgatc tcggctcact gcaagctcca cctcccaggt     7560

tcacgccatt ctcctgcctc agcctcccaa gtagctggga ctacaggctc ccgccaccac     7620

gcccggctaa ttttttgtat ttttagtaga gacggggttt caccctgtta gccaggatgg     7680

tctcgatctc ctgacctcat gatccacccg cctcggcctc ccaaagtgct gggattacag     7740

gcgtgagcca ccgcgcccgg cccgttgtat ctattttttt tagacgcatc aattcagtgt     7800

ctctgaagcc tttgatcgtt aggaaggtca gtacataacc tcttaggtga agctgagttg     7860

atctttggag cccaagagag ttaattttca ggagaaaaag aattagggca agctcccctg     7920

tgggatgtta agagaaagtc catatgcgct tcttccatct ctgcctcttg tttttaaata     7980

agtgcttgtg aagttcagtt tatagaggtt gagtctcagt gcttcctcag ccagggtggt     8040

ttattgctgt tttacaaaga accatgaaca agcaaaatcc tatcaatagt cctttctgtt     8100

ttatgtttta tagtcttatt ttgaagaatc ggcatggtaa aatgatagac aagtttcaaa     8160

taaagcagat aattagctct agaattgggg tactttgcct caggtacagc atctgtcttg     8220

aatacatagt gatggctgtg tcacacatgg gtacatttac tttcctctct gatcaactgc     8280

accccttttt actggcaaag agggctccta ctttctacac acttaaccag tcaaacagat     8340

aggttttggc accaccgaaa gaaccacaag tgcaccccag ctgcatctgg gcatggtttt     8400

ggtactagga ctagagaagt gagcagtaaa tgacagtcct taccctagga agagatggga     8460

gaagagaggt gtccagacat atttaccttt tctcttctgt catgccccaa gaaccaagga     8520

tcatctttga agtgacgtct tttttgttaa attggaagaa gaaaactttg cagccaggcg     8580

tggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggcgg atcacaaagt     8640

gtcaggagtt tgagaacagc ctggccaaca tggtgaaacc ccatctctac tgaaaataca     8700

aaatcccagc tacttgggag gctgaggcaa gagaatcact tgaacctggg aggcggatgt     8760

tgcagtgagc cgagatcacg ccactgcact ccagcctggg caacggagtg agactccatc     8820

tcacaaaaaa gagaaaagaa aagaaaactt tgcttcacta agtttctctt gccattatct     8880

cattaattca gatctgtacc tcattgctgc tcacacatat atgtttctta ccttagcctg     8940

aaccttctca ggccttgaag tcattattct actctttttt tttcttttcc ttttttatgg     9000

cactagagaa tgaaaaccta aggtcttaga aaatcttaac ttgaaaaagt ctctaactgg     9060

catgatttga ttactttttt cccctgtgga caaataattt tctttcctat ataatagatt     9120

tttagtaagt gaaacctttg ctgctgcttt cctgggttta cattagtttt ttcctgccct     9180

taagaataat ttatctgtgc ttctctgatg actgttaatt tctaatagtg caggaaggga     9240

tgagcttttg atttcttctc actcccctcc tcaccctact tccaaattac acactaactt     9300

ctaaccctta cagcctgttg gcacatacac aagatccacg agaccatgct cctcagaagc     9360

tacccatgtc ctttctcacc atggtgtggc tcttggagcc ctgagtatct gtgactaccc     9420

actccaaagg ttgactgtaa gaggagagcg gccttcttaa ttttgcattt cttaattttg     9480

tttttctcca ttcctgtttt atgacttggc cttcagatgc ttcctactct ggcctcctcc     9540

ttttttctcc taggaattgt ttccaggtaa cctaccatgt gcacttctca gctgctctgc     9600

tcacctttgc ccaccttccc gtgaccctga gagtacagat ccgaataatg tggcctgtgc     9660

agagctcaga gaactgtgag gactacccat gcctgtcaga ctctgctcag ggacagagat     9720

ggatgggtaa atggtgctgt tggagacatt tttatcttca taccaggctc tgtttcatcc     9780

ctgcaccccg cacccccact cactcccctg agggggtaaa atgcagaggt ggttgacctg     9840

aagggtctga ttccctcctt cccaagcctt agggcctacc ctggagtgct gcagtgtgtg     9900

agagctgctg cttgcttgtt tctccactag gcctgctcca aatgcttagc caatctctgg     9960

agccgacaca gttgcctacg gggtgactta gcaccaggtt ccattagctc tccaagtgac    10020

tgtttccacc cagtactttt ggcgcttgag gatgggggga gggggattat ttaaaataaa    10080

taaaatccga ggtggcagta gaggattcct tttgctttaa aaatctttgg actaaaaaaa    10140

aaaaaaaaaa gttttttata tataaatata taaagtaaat tgttatgtaa ctattattgt    10200

ttcttgtatg ttctaatttt gttttatgat gtaattaaag aaagtaagct gtgaagactt    10260

ttcattttcc tgtg                                                      10274


<210> 2344
<211> 3288
<212> DNA
<213> Homo sapiens

<400> 2344
ctcctcttcc taaagcggcg aggcgcagag gagcggcatc actcgagccc aggtcccagc       60

caccaccact cacagcgctc ggcgttcagg aagaggagca gcagcggagg cggctgcttc      120

agcggcgggc gggcgccaga aaggccccga tcgaaaagcc tgggagggcc gccgaactac      180

ccccggaggg aggagccagt ccgaacccaa ggcgccaccg ccgcagaagc ggagcgaggc      240

agcattcgcc tccatggccc actcgccggt ggctgtccaa gtgcctggga tgcagaataa      300

catagctgat ccagaagaac tgttcacaaa attagagcgc attgggaaag gctcatttgg      360

ggaagttttc aaaggaattg ataaccgtac ccagcaagtc gttgctatta aaatcataga      420

ccttgaggaa gccgaagatg aaatagaaga cattcagcaa gaaataactg tcttgagtca      480

atgtgacagc tcatatgtaa caaaatacta tgggtcatat ttaaaggggt ctaaattatg      540

gataataatg gaatacctgg gcggtggttc agcactggat cttcttcgag ctggtccatt      600

tgatgagttc cagattgcta ccatgctaaa ggaaatttta aaaggtctgg actatctgca      660

ttcagaaaag aaaattcacc gagacataaa agctgccaat gtcttgctct cagaacaagg      720

agatgttaaa cttgctgatt ttggagttgc tggtcagctg acagatacac agattaaaag      780

aaataccttt gtgggaactc cattttggat ggctcctgaa gttattcaac agtcagctta      840

tgactcaaaa gctgacattt ggtcattggg aattactgct attgaactag ccaagggaga      900

gccacctaac tccgatatgc atccaatgag agttctgttt cttattccca aaaacaatcc      960

tccaactctt gttggagact ttactaagtc ttttaaggag tttattgatg cttgcctgaa     1020

caaagatcca tcatttcgtc ctacagcaaa agaacttctg aaacacaaat tcattgtaaa     1080

aaattcaaag aagacttctt atctgactga actgatagat cgttttaaga gatggaaggc     1140

agaaggacac agtgatgatg aatctgattc cgagggctct gattcggaat ctaccagcag     1200

ggaaaacaat actcatcctg aatggagctt taccaccgta cgaaagaagc ctgatccaaa     1260

gaaagtacag aatggggcag agcaagatct tgtgcaaacc ctgagttgtt tgtctatgat     1320

aatcacacct gcatttgctg aacttaaaca gcaggacgag aataacgcta gcaggaatca     1380

ggcgattgaa gaactcgaga aaagtattgc tgtggctgaa gccgcctgtc ccggcatcac     1440

agataaaatg gtgaagaaac taattgaaaa atttcaaaag tgttcagcag acgaatcccc     1500

ctaagaaact tattattggc ttctgtttca tatggaccca gagagcccca ccaaacctac     1560

gtcaagatta acaatgctta acccatgagc tccatgtgcc ttttggatct ttgcaacact     1620

gaagatttgg aagaagctat taaactattt tgtgatggcg tttatcattt tatattttga     1680

aaggattatt ttgtaaggaa taacttttaa tactatagtt tcacctgtat tctagtaaat     1740

gttgagacac cgttttgctt ttaagtatcc ctatttctta agttacgagg atgaatacct     1800

ttcacatttt gatctttagt tgactctaca gtcatgaaac atacaggtct ttcaaagtca     1860

ttctcaatat tcagcttttg taaattatca agcttcaaaa agcttttttt tttaaaaaaa     1920

aacatgcata ttctaaaaat gactattggt ggggaggtgt aaataagtca taccttctta     1980

aaacagaaaa tttaagtaaa gtcttttaaa tgaaacctgt aaaagtattg actcttctac     2040

caagttggta tgatattcca ggcagctcaa tgattatcac atttgagacc ctgtgtttga     2100

agcatttaca ggcaatgtac agcaacagag gtacctcttg gtgtatagta tttacattct     2160

cttttaggta gaagaggcaa ttttaccctt atttcacatg gttagaaatt taaagcaaga     2220

tcatttaccc aaggataggt gtttggtaat gttgaaggag ttagtctggc ttcatgtttt     2280

acatcttcaa ctaaaatccc atactatctg cttggatttg gagagccaaa aaataaagct     2340

gattgtcatg tgattaaata tctgatcaac aggtatgaat ataacttaaa tcagcatatt     2400

tttgccatgg taataaattg tcctataaac tatttatata tttttgttct tcataattat     2460

cactaataag catcagtttg ttgtttttaa aaggatattt aagtgagcat tttctagttc     2520

atatgaaaat aaccatagta caggatgatt tctgtccaca caaaggttaa attagattgc     2580

acagttaatt ttcacttata tttatggtac tattatgtgg gtgatgcctt tttcttttaa     2640

gcccagtaca tatattatgc ctgcctaagt tctgaactgg ggctgtattt cagtagttgt     2700

agaattattg atatttagtt ttgatagcta atgtttaatt gtttggatct gcacagtttg     2760

gtttttgcac aaaagtcatt taaaaaaatc tgagtaattg tcaaatatta aaagaaagat     2820

attcttcctg taaggaatac agtttttagt caaagtggcc attacatcct ctttttaatt     2880

tacataatac agatacttga gaaagttgtt gtggtgttgt atgccaagaa aattcttttt     2940

attggtgcct atattgtaac aattattttt aatgcattgt attttgaagt aacggttcag     3000

ttaaattttt cacctgctgt gtaactgaaa cacaattaca gtttataatc atctgtagaa     3060

gtctggagat aattttgcaa ctcatgttat gggttaaatg aatatttttg taaaagtaaa     3120

agcaacaaat ttataaattg attatttgaa actttacaac acaattgcat cccaaataca     3180

aattgtattg cttattcatt atagctattc gtcctgtaat ctgtttctag gtgaagcata     3240

ctccagtgtt ttaggggttt tgaaaataaa tatttaaatt tcacagtc                  3288


<210> 2345
<211> 3017
<212> DNA
<213> Homo sapiens

<400> 2345
actcgagccc aggtcccagc caccaccact cacagcgctc ggcgttcagg aagaggagca       60

gcagcggagg cggctgcttc agcggcgggc gggcgccaga aaggccccga tcgaaaagcc      120

tgggagggcc gccgaactac ccccggaggg aggagccagt ccgaacccaa ggcgccaccg      180

ccgcagaagc ggagcgaggc agcattcgcc tccatggccc actcgccggt ggctgtccaa      240

gtgcctggga tgcaggggtc taaattatgg ataataatgg aatacctggg cggtggttca      300

gcactggatc ttcttcgagc tggtccattt gatgagttcc agattgctac catgctaaag      360

gaaattttaa aaggtctgga ctatctgcat tcagaaaaga aaattcaccg agacataaaa      420

gctgccaatg tcttgctctc agaacaagga gatgttaaac ttgctgattt tggagttgct      480

ggtcagctga cagatacaca gattaaaaga aatacctttg tgggaactcc attttggatg      540

gctcctgaag ttattcaaca gtcagcttat gactcaaaag ctgacatttg gtcattggga      600

attactgcta ttgaactagc caagggagag ccacctaact ccgatatgca tccaatgaga      660

gttctgtttc ttattcccaa aaacaatcct ccaactcttg ttggagactt tactaagtct      720

tttaaggagt ttattgatgc ttgcctgaac aaagatccat catttcgtcc tacagcaaaa      780

gaacttctga aacacaaatt cattgtaaaa aattcaaaga agacttctta tctgactgaa      840

ctgatagatc gttttaagag atggaaggca gaaggacaca gtgatgatga atctgattcc      900

gagggctctg attcggaatc taccagcagg gaaaacaata ctcatcctga atggagcttt      960

accaccgtac gaaagaagcc tgatccaaag aaagtacaga atggggcaga gcaagatctt     1020

gtgcaaaccc tgagttgttt gtctatgata atcacacctg catttgctga acttaaacag     1080

caggacgaga ataacgctag caggaatcag gcgattgaag aactcgagaa aagtattgct     1140

gtggctgaag ccgcctgtcc cggcatcaca gataaaatgg tgaagaaact aattgaaaaa     1200

tttcaaaagt gttcagcaga cgaatccccc taagaaactt attattggct tctgtttcat     1260

atggacccag agagccccac caaacctacg tcaagattaa caatgcttaa cccatgagct     1320

ccatgtgcct tttggatctt tgcaacactg aagatttgga agaagctatt aaactatttt     1380

gtgatggcgt ttatcatttt atattttgaa aggattattt tgtaaggaat aacttttaat     1440

actatagttt cacctgtatt ctagtaaatg ttgagacacc gttttgcttt taagtatccc     1500

tatttcttaa gttacgagga tgaatacctt tcacattttg atctttagtt gactctacag     1560

tcatgaaaca tacaggtctt tcaaagtcat tctcaatatt cagcttttgt aaattatcaa     1620

gcttcaaaaa gctttttttt ttaaaaaaaa acatgcatat tctaaaaatg actattggtg     1680

gggaggtgta aataagtcat accttcttaa aacagaaaat ttaagtaaag tcttttaaat     1740

gaaacctgta aaagtattga ctcttctacc aagttggtat gatattccag gcagctcaat     1800

gattatcaca tttgagaccc tgtgtttgaa gcatttacag gcaatgtaca gcaacagagg     1860

tacctcttgg tgtatagtat ttacattctc ttttaggtag aagaggcaat tttaccctta     1920

tttcacatgg ttagaaattt aaagcaagat catttaccca aggataggtg tttggtaatg     1980

ttgaaggagt tagtctggct tcatgtttta catcttcaac taaaatccca tactatctgc     2040

ttggatttgg agagccaaaa aataaagctg attgtcatgt gattaaatat ctgatcaaca     2100

ggtatgaata taacttaaat cagcatattt ttgccatggt aataaattgt cctataaact     2160

atttatatat ttttgttctt cataattatc actaataagc atcagtttgt tgtttttaaa     2220

aggatattta agtgagcatt ttctagttca tatgaaaata accatagtac aggatgattt     2280

ctgtccacac aaaggttaaa ttagattgca cagttaattt tcacttatat ttatggtact     2340

attatgtggg tgatgccttt ttcttttaag cccagtacat atattatgcc tgcctaagtt     2400

ctgaactggg gctgtatttc agtagttgta gaattattga tatttagttt tgatagctaa     2460

tgtttaattg tttggatctg cacagtttgg tttttgcaca aaagtcattt aaaaaaatct     2520

gagtaattgt caaatattaa aagaaagata ttcttcctgt aaggaataca gtttttagtc     2580

aaagtggcca ttacatcctc tttttaattt acataataca gatacttgag aaagttgttg     2640

tggtgttgta tgccaagaaa attcttttta ttggtgccta tattgtaaca attattttta     2700

atgcattgta ttttgaagta acggttcagt taaatttttc acctgctgtg taactgaaac     2760

acaattacag tttataatca tctgtagaag tctggagata attttgcaac tcatgttatg     2820

ggttaaatga atatttttgt aaaagtaaaa gcaacaaatt tataaattga ttatttgaaa     2880

ctttacaaca caattgcatc ccaaatacaa attgtattgc ttattcatta tagctattcg     2940

tcctgtaatc tgtttctagg tgaagcatac tccagtgttt taggggtttt gaaaataaat     3000

atttaaattt cacagtc                                                    3017


<210> 2346
<211> 2910
<212> DNA
<213> Homo sapiens

<400> 2346
aggttgttac catggagatg gctaacagct agagcaggct gtcctcggag ggagacattc       60

catctccaga cacccagaga cgctccagaa tggaggtcct gagggagaag gtggaggagg      120

aggaggaggc cgagcgggag gaggcggccg agtgggctga atgggcgagg atggagaaaa      180

tgatgaggcc agttgaggtg cggaaggagg aaatcacctt aaagcaggag acgctcagag      240

acctggagaa gaagctgtca gagatccaga tcactgtctc agcggagctc ccggccttta      300

ccaaggacac tattgacatc tccaagctgc ccatttccta caaaaccaac acacccaagg      360

aggaacacct gctgcaggtg gcagacaact tctcccgcca gtacagccat ctgtgcccgg      420

accgcgtgcc cctcttcctg caccccctga acgagtgtga agtgcccaag ttcgtgagca      480

caaccctccg gcccacactg atgccctacc ccgagctcta caactgggac agctgtgccc      540

agtttgtctc cgacttcctc accatggtgc ccctgcctga ccctctcaag ccgccctcgc      600

acctgtactc ctcgaccact gtgctcaagt accagaaggg gaactgcttt gacttcagta      660

cgctgctctg ctccatgctt atcggctctg gctatgatgc ttactgcgtc aacggctacg      720

gctcgctgga cctgtgccac atggacctga cgcgggaggt gtgcccactc actgtgaagc      780

ccaaggagac catcaagaag gaggaaaagg tgctgcctaa gaagtatacc atcaaacccc      840

ccagggacct gtgcagcagg tttgagcagg agcaagaggt gaagaagcag caggagatca      900

gagcccagga gaagaagcgg ctgagggagg aggaggagcg cctcatggaa gcggagaagg      960

caaagccgga tgccctgcac ggcctgcggg tgcactcctg ggtccttgtg ctatcgggga     1020

agcgcgaggt gcctgagaac ttcttcatcg acccattcac aggacatagc tacagcaccc     1080

aggatgagca cttcctgggc atcgaaagcc tgtggaacca caagaactac tggatcaaca     1140

tgcaggattg ctggaactgc tgcaaggact tgatctttga cctgggtgac cctgtgagat     1200

gggagtacat gctcctgggg actgataagt ctcagctgtc cttgactgaa gaagacgaca     1260

gtgggataaa cgatgaggat gatgtggaaa atctgggcaa ggaggatgag gataagagct     1320

tcgacatgcc ccactcgtgg gtggagcaga ttgagatctc cccggaagca tttgagaccc     1380

gctgcccgaa cgggaagaag gtgattcagt acaagagggc aaagctggag aagtgggccc     1440

cgtacctcaa tagcaatggc cttgtgagcc gcctcaccac ctatgaggac ttgcagtgta     1500

ccaatatttt ggagataaag gagtggtacc agaaccggga agacatgctg gagctgaaac     1560

acataaacaa gaccacagac ctgaagacag actacttcaa gcctggccac ccccaggctc     1620

tgcgcgtgca ctcgtacaag tccatgcaac ctgagatgga ccgtgtcatt gagttttatg     1680

aaacggcccg tgtggatggc ctgatgaagc gggaggagac acccaggaca atgacagagt     1740

actatcaagg acgcccagac ttcctctcct accgccatgc cagcttcgga ccccgagtca     1800

agaagctcac tctgagcagt gcagagtcaa acccccggcc cattgtgaaa atcacagagc     1860

ggttcttccg caacccagcg aagcccgcgg aggaggacgt ggcagagcgc gtgtttctgg     1920

tcgcggagga gcgcatccag ctgcgctacc actgccgtga ggaccacatc acggcctcca     1980

agcgcgagtt cctgcggcgc accgaggtgg acagcaaagg caacaagatc atcatgacgc     2040

ccgacatgtg catcagcttc gaggtggagc ccatggagca caccaagaag ctgctctacc     2100

agtacgaggc catgatgcac ctgaagaggg aggagaagct gtccagacat caggtctggg     2160

agtcagagct ggaggtgctg gagattctga agcttcgaga ggaagaggag gcggcgcaca     2220

cactgaccat ctccatctat gacaccaagc ggaatgagaa gagcaaggaa tatcgggagg     2280

ccatggagcg catgatgcac gaagagcacc tgcggcaggt ggagacccag ctggactacc     2340

tggccccatt cctggcccag ctcccgccag gagagaaact aacatgctgg caggcggtgc     2400

gcctcaagga tgagtgcctc agcgacttca agcagcggct catcaacaag gccaacctca     2460

tccaggcccg ctttgagaag gagacccagg agctgcaaaa gaagcagcag tggtaccagg     2520

agaaccaggt gacgctgaca cccgaggatg aagacctgta cctgagttac tgctctcagg     2580

ccatgttccg catccgcatc ctggagcagc gcctcaatcg acacaaggaa ctggccccac     2640

tgaagtacct ggctctggag gaaaagctct acaaggaccc acgcctgggg gagctccaga     2700

aaatattcgc ttgatgtccc tcctggggcc tcagccagag ctgccagaga aaggaaacct     2760

cttcccgcag cctggctcct gtgttccctc tatccagcca atgcctgttt acacagacac     2820

ctggcctcac tgccagccca cctcccctac agccctgttt gttcctgctt ctcatgattt     2880

tcctgtaaat aaacacactc ttaatttgcc                                      2910


<210> 2347
<211> 7356
<212> DNA
<213> Homo sapiens

<400> 2347
gttttgatga acacctggct ttattcttgc aatgaagaaa ggttctcaac aaaaaatatt       60

ctccaaagca aagataccat catcatctca ctctcctatc ccatcatcta tgtccaatat      120

gagatctagg tcactttcac ctttgattgg atcagagact ctaccttttc attctggagg      180

acagtggtgt gagcaagttg agattgcaga tgaaaacaat atgcttttgg actatcaaga      240

ccataaagga gctgattcac atgcaggagt tagatatatt acagaggccc tcattaaaaa      300

acttactaaa caggataatt tggctttgat aaaatctctg aacctttcac tttctaaaga      360

cggtggcaag aaatttaagt atattgagaa tttggaaaaa tgtgttaaac ttgaagtact      420

gaatctcagc tataatctaa tagggaagat tgaaaagttg gacaagctgt taaaattacg      480

tgaactcaac ttatcatata acaaaatcag caaaattgaa ggcatagaaa atatgtgtaa      540

tctgcaaaag cttaaccttg caggaaatga aattgagcat attccagtat ggttagggaa      600

gaagttaaaa tctttgcgag tcctcaattt gaaaggcaac aagatatcat cgctccaaga      660

tataagcaag ttgaaaccgc ttcaagattt gatttctctg atcctagttg aaaatccagt      720

tgtgaccctt cctcattacc tccagtttac cattttccac ctccgttcat tggaaagttt      780

ggaaggtcag ccagtaacca ctcaggatag acaggaggct tttgagagat tcagtttaga      840

agaggtagaa agactggaaa gagacctaga aaaaaagatg atagaaactg aagagcttaa      900

gagcaaacaa acaaggttcc ttgaggaaat taaaaatcaa gataaattga ataaatcatt      960

aaaagaggag gccatgttac agaaacagag ctgtgaggaa ctcaagagtg acttaaacac     1020

aaaaaatgaa ttgctaaaac agaagaccat agaattaaca cgagcatgtc agaagcaata     1080

tgagctggaa caggaattgg ccttttataa aattgatgct aaatttgagc cactaaatta     1140

ttatccatca gagtatgctg aaattgataa agccccagat gaaagccctt acattggcaa     1200

atccagatac aagagaaata tgtttgccac agagagttat attattgaca gtgctcaggc     1260

agtacagatc aagaagatgg agccagatga acaacttaga aatgatcaca tgaacttgag     1320

aggccacaca ccactggaca cgcaactgga agacaaagaa aaaaaaataa gtgcagcaca     1380

aactcgacta tcagaactgc atgatgaaat agaaaaggca gaacaacaaa ttttgagagc     1440

tactgaagaa tttaaacaac tggaagaagc tatacaacta aaaaagattt cagaagcagg     1500

gaaagacctt ctttacaagc agttgagtgg tagactacaa cttgtaaata aattacgcca     1560

ggaagctctg gatctagaac tgcagatgga aaagcaaaag caggaaattg ccggaaagca     1620

gaaggagatt aaggacctgc aaatagccat agatagcctg gattccaaag acccaaaaca     1680

ttcccatatg aaggctcaaa agagcggtaa agaacaacag cttgacatta tgaacaagca     1740

gtaccaacaa cttgaaagtc gtttggatga gatactttct agaattgcta aggaaacgga     1800

agagattaag gaccttgaag aacagcttac tgaaggccag atagcagcaa atgaagccct     1860

gaagaaggat ttagaaggtg ttatcagtgg gttgcaagaa tacctgggga ccattaaagg     1920

ccaggcaact caggcccaga atgagtgcag gaagctgcgg gatgagaaag agacattgtt     1980

gcagagattg acagaagtcg agcaggagag agaccagctg gaaatagttg ccatggatgc     2040

agaaaatatg aggaaggagc ttgcagagct agaaagtgcc ctccaagagc agcatgaggt     2100

gaatgcatct ttgcagcaga cccagggaga tctcagtgcc tatgaagctg agctagaggc     2160

tcggctaaac ctaagggatg ctgaagccaa ccagctcaag gaagagttgg aaaaagtaac     2220

aagacttacc cagttagaac aatcagccct tcaagcagaa cttgagaagg aaaggcaagc     2280

cctcaagaat gcccttggaa aagcccagtt ctcagaagaa aaggagcaag agaacagtga     2340

gctccatgca aaacttaaac acttgcagga tgacaataat ctgttaaaac agcaacttaa     2400

agatttccag aatcacctta accatgtggt tgatggtttg gttcgtccag aagaagtggc     2460

agctcgtgtg gatgagctaa gaagaaaact gaaattagga actggggaaa tgaacatcca     2520

tagtccttca gatgtcttag ggaaaagtct tgctgattta cagaaacaat tcagtgaaat     2580

tcttgcacgc tccaagtggg aaagagatga agcacaagtt agagagagaa aactccaaga     2640

agaaatggct ctgcagcaag agaaactggc aactggacaa gaagagttca ggcaggcctg     2700

tgagagagcc ctggaagcaa gaatgaattt tgataagagg caacatgaag caagaatcca     2760

gcaaatggag aatgaaattc actatttgca agaaaatcta aaaagtatgg aggaaatcca     2820

aggccttaca gatctccaac ttcaggaagc tgatgaagag aaggagagaa ttctggccca     2880

actccgagag ttagagaaaa agaagaaact tgaagatgcc aaatctcagg agcaagtttt     2940

tggtttagat aaagaactga agaaactaaa gaaagccgtg gccacctctg ataagctagc     3000

cacagctgag ctcaccattg ccaaagacca gctgaagtcc cttcatggaa ctgttatgaa     3060

aattaaccag gagcgagcag aggagttgca ggaagcagag aggttcagca gaaaggcagc     3120

acaagcagcc agagatctca cccgagcaga agctgagatc gaactcctgc agaatctcct     3180

caggcagaag ggggagcagt ttcgacttga gatggagaaa acaggtgtag gtactggagc     3240

aaactcacag gtcctagaaa ttgagaaact gaatgagaca atggaacgac aaaggacaga     3300

gattgcaagg ctgcagaatg tactagacct cactggaagt gacaacaaag gaggctttga     3360

aaatgtttta gaagaaattg ctgaacttcg acgtgaagtt tcttatcaga atgattacat     3420

aagcagcatg gcagatcctt tcaaaagacg aggctattgg tactttatgc caccaccacc     3480

atcatcaaaa gtttccagcc atagttccca ggccaccaag gactctggtg ttggccttaa     3540

gtactcagcc tcaactcctg ttagaaaacc acgccctggg cagcaggatg ggaaggaagg     3600

cagtcaacct ccccctgcct caggatactg ggtttattct cccatcagga gtgggttaca     3660

taaactgttt ccaagtagag atgcagacag tggaggagat agtcaggaag agagtgagct     3720

ggatgaccaa gaagaacccc catttgtgcc tcctcctgga tacatgatgt atactgtgct     3780

tcctgatggt tctcctgtac cccagggcat ggccctgtat gcaccacctc ctcccttgcc     3840

aaacaatagc cgacctctca cccctggcac tgttgtttat ggcccacctc ctgctggggc     3900

ccccatggtg tatgggcctc caccccccaa cttctccatc cccttcatcc ctatgggtgt     3960

gctgcattgc aacgtccctg aacaccataa cttagagaat gaagtttcta gattagaaga     4020

cataatgcag catttaaaat caaagaagcg ggaagaaagg tggatgagag catccaagcg     4080

gcagtcggag aaagaaatgg aagaactgca tcataatatt gatgatcttt tgcaagagaa     4140

gaaaagctta gagtgtgaag tagaagaatt acatagaact gtccagaaac gtcaacagca     4200

aaaggacttc attgatggaa atgttgagag tcttatgact gaactagaaa tagaaaaatc     4260

actcaaacat catgaagata ttgtagatga aattgagtgc attgagaaga ctcttctgaa     4320

acgtcgctca gagctcaggg aagctgaccg actcctggca gaggctgaga gtgaactttc     4380

atgcactaaa gaaaagacaa aaaatgctgt tgaaaagttc actgatgcca agagaagttt     4440

attgcaaact gagtcagatg ctgaggaatt agaaaggaga gctcaggaaa ctgctgttaa     4500

cctcgtcaaa gctgatcagc agctaagatc gctccaggct gatgcaaagg atttggagca     4560

gcacaaaatc aagcaagaag aaatcttgaa agaaataaac aaaattgtag cagcaaaaga     4620

ctcagacttc caatgtttaa gcaagaagaa ggaaaaactg acagaagagc ttcagaaact     4680

acagaaagac atagagatgg cagaacgcaa tgaggatcac cacctgcagg tccttaaaga     4740

atctgaggtg cttcttcagg ccaaaagagc cgagctggaa aagctgaaaa gccaggtgac     4800

aagtcagcag caggagatgg ctgtcttgga caggcagtta gggcataaaa aggaggagct     4860

gcatctactc caaggaagca tggtccaggc aaaagctgac ctccaggaag ctctgagact     4920

gggagagact gaagtaactg agaagtgcaa tcacattagg gaagtaaaat ctcttctgga     4980

agaactgagt tttcagaaag gagaactaaa tgttcagatt agtgaaagaa aaactcaact     5040

tacacttata aagcaggaaa ttgaaaaaga ggaagaaaat cttcaggttg ttttaaggca     5100

gatgtctaaa cataaaaccg aactaaagaa tattctggac atgttgcaac ttgaaaacca     5160

tgagctacaa ggtttgaagc tacaacatga ccaaagggta tctgaattag agaagactca     5220

ggtggcagtg ctagaggaga aactggagtt agagaatttg cagcagatat cccagcagca     5280

gaaaggggaa atagagtggc agaagcagct ccttgagagg gataaacgag aaatagaacg     5340

aatgactgct gagtcccgag ctttacaatc gtgtgttgag tgtttgagca aagaaaagga     5400

agatctccaa gagaaatgtg acatttggga aaaaaagttg gcacaaacca aaagggtttt     5460

agcagcagca gaagaaaata gcaaaatgga gcaatcaaac ttagaaaagt tggaattgaa     5520

tgtcagaaaa ctgcagcagg aactagacca actaaacaga gacaagttgt cactgcataa     5580

cgacatttca gcaatgcaac agcagctcca agaaaaacga gaagcagtaa actcactgca     5640

ggaggaacta gctaatgtcc aagaccattt gaacctagca aaacaggacc tgcttcacac     5700

caccaagcat caggatgtgt tgctcagtga gcagacccga ctccagaagg acatcagtga     5760

atgggcaaat aggtttgaag actgtcagaa agaagaggag acaaaacaac aacaacttca     5820

agtgcttcag aatgagattg aagaaaacaa gctcaaacta gtccaacaag aaatgatgtt     5880

tcagagactc cagaaagaga gagaaagtga aaaaagcaaa ctggaccaag tgctctcaaa     5940

ggtgctggca gctgaagagc gtgttaggac tctgcaggaa gaggagaggt ggtgtgagag     6000

cctggagaag acactctccc aaactaaacg gcagctttca gaaagggagc agcaattggt     6060

ggagaaatca ggtgagctgt tggccctcca gaaagaggca gattctatga gggcagactt     6120

cagccttctg cggaaccagt tcttgacaga aagaaagaaa gctgagaagc aggtggccag     6180

cctgaaggaa gcacttaaga tccagcggag ccagctggag aaaaaccttc ttgagcaaaa     6240

acaggagaac agctgcatac aaaaggaaat ggcaacaatt gaactggtag cccaggacaa     6300

ccatgagcgg gccaggcgcc tgatgaagga gctcaaccag atgcagtatg agtacacgga     6360

gctcaagaaa cagatggcaa accaaaaaga tttggagaga agacaaatgg aaatcagtga     6420

tgcaatgagg acacttaaat ctgaggtgaa ggatgaaatc agaaccagct tgaagaatct     6480

taatcagttt cttccagaac taccagcaga tctagaagct attttggaaa gaaacgaaaa     6540

cctagaagga gaattggaaa gcttgaaaga gaaccttcca tttaccatga atgagggacc     6600

ttttgaagaa aaactgaact tttcccaagt tcacataatg gatgaacact ggcgtggaga     6660

agcactccgg gagaaactgc gtcaccggga agaccgactc aaggcccaac tccgacactg     6720

tatgtccaag caagcagaag tattaattaa aggaaagcgg cagacagagg gcactttaca     6780

cagtttgagg agacaagtag atgctttagg ggaattggtc accagcacct ctgcagattc     6840

agcgtcatca cccagtctgt ctcagctgga gtcttccctc acagaggact ctcaacttgg     6900

acaaaatcag gaaaagaatg cctcagccag atgaggaata ctgtcttgtg taaatatatt     6960

caaggaaaac acctccacta cctcactgac ttcataattg gaatgtcaca tggttttttt     7020

aatcaagatg cagtgaactg agattctgaa actccactgt agtttacttt gcctgtacca     7080

ttaatgccaa tgtttttata aatcacttgt acatagtaca tatgggaata gttgcatatg     7140

ggaatttaaa ccaacatgtg gctgagcctt ttttttttta atcttcgtaa catgtttaaa     7200

aaaaaacagt gattttaact gcatatttga acctacaaac tggtaaatct tattaacaaa     7260

aagaatgtac ttaaggccct ctttatttat agtgtcgagt tatttttgaa ttttgcttaa     7320

aatctatttt tcatatgaaa ataaaagata acaatc                               7356


<210> 2348
<211> 3859
<212> DNA
<213> Homo sapiens

<400> 2348
gaaggcagcg gcaggtcggg agcaagatgg cgctgcggcc aggagctggt tctggtggcg       60

gcggggccgc gggagctggc gcggggtccg ccgggggagg cggcttcatg tttcctgttg      120

caggtgggat aagaccccct caagcaggcc tgatgccgat gcagcaacaa ggatttccta      180

tggtctctgt catgcagcct aatatgcaag gcattatggg aatgaattac agctctcaga      240

tgtcccaagg acctattgct atgcaggcag gaataccaat gggaccaatg ccagcagcgg      300

gaatgcctta cctaggacaa gcacccttcc tgggcatgcg tcctccaggc ccacagtaca      360

ctccagacat gcagaagcag tttgccgaag agcagcagaa acgatttgaa cagcagcaaa      420

aactcttaga agaagaaaga aaaagacgcc agtttgaaga gcagaagcaa aagctcagac      480

ttttgagcag tgtgaaaccc aagacaggag agaagagtag agatgatgct ttggaagcca      540

taaaaggaaa tttagatggg ttttccagag atgcaaaaat gcaccctact ccagcatcgc      600

accccaagaa accaggtgtg ggagtatttc cctcacagga tcctgctcag cccagaatgc      660

ctccttggat ttacaatgag agtttggttc cagatgccta taagaaaatc ttagaaacca      720

caatgactcc aactggaata gatactgcca aactgtatcc cattctgatg tcatctgggc      780

ttcccaggga aactcttgga cagatatggg ccttagctaa tcgaactaca cctggcaaac      840

ttacaaaaga agaactttat accgttctag ccatgatagc ggtaacacag aggggcgttc      900

ctgcaatgag tcctgatgct ttaaaccagt tcccagcagc tcctattcca actttaagtg      960

gcttttctat gactctgcct acaccggtga gtcagccaac tgtgatacct tcaggtcctg     1020

cgggctccat gcccctcagc cttggacagc cagtcatggg cattaacctt gttggaccag     1080

tgggtggagc tgcagcccag gcttctagtg gtttcatacc aacctaccct gcaaatcagg     1140

tagtaaagcc agaagaagat gacttccagg attttcaaga tgcttctaag tcaggatccc     1200

ttgatgactc attcagtgat ttccaagagt tgcctgcttc ttcaaaaaca agtaactccc     1260

agcatggaaa cagtgcccct tctttgttga tgccacttcc tggaactaaa gcattgcctt     1320

caatggacaa atatgctgtg tttaaaggaa ttgcagctga caagtcctct gaaaatactg     1380

ttccacctgg agatcctggt gataaatata gtgctttcag agaacttgaa cagacagcag     1440

agaataaacc tttaggagaa agctttgcag aattcagatc tgcaggaact gatgatggtt     1500

tcaccgattt taaaacagcc gatagtgtat caccactaga gccaccaaca aaagacaaaa     1560

cttttccacc atccttcccc tcaggaacta tacaacagaa acaacaaaca caagtgaaaa     1620

accctctgaa cttagcagac ctagatatgt tttcctcagt taattgcagc agcgagaaac     1680

cattgtcttt ttcagctgtg tttagcacat caaaatcagt ttctacacca cagtcaacag     1740

gttctgctgc tactatgaca gcattggcag caacaaaaac ttctagtttg gctgatgatt     1800

ttggagaatt cagccttttt ggggaatatt ctggtctagc acctgttggg gagcaggatg     1860

actttgcaga ttttatggct ttcagtaata gctctatttc atctgagcaa aagccggatg     1920

acaaatatga tgcccttaaa gaggaagcca gtcctgttcc tctaaccagc aacgtgggca     1980

gcacagtgaa gggtggacaa aactcgactg ctgcgtctac caagtacgat gtcttcagac     2040

aactttctct ggaagggtct ggactaggtg ttgaagacct gaaagataac actccttcag     2100

gaaaaagtga tgatgatttt gctgacttcc actccagtaa attttcttcc ataaactcgg     2160

acaaatccct gggagagaaa gcagtggctt tcagacacac caaagaagac tctgcatcag     2220

tgaagtcctt agatctccct tccattggtg gcagcagtgt tggcaaggag gactctgaag     2280

atgcactctc tgttcagttt gacatgaaat tggctgatgt gggaggagat cttaagcatg     2340

tcatgtctga tagctctttg gatttaccaa cagttagtgg ccagcatcct cctgctgcag     2400

atatagagga cttaaaatat gctgcttttg gaagctacag tagcaatttt gcagtgagca     2460

cacttacaag ctatgactgg tcagacaggg atgatgcaac tcagggcaga aaactctctc     2520

catttgtcct ctcagcagga agtggatccc cctcagccac ctcaattctt caaaagaaag     2580

agacttcatt tggcagttct gaaaacatca ccatgacatc tctctccaaa gtaacgacct     2640

ttgtaagtga agatgctctt ccagagacca ccttcccagc tcttgccagt tttaaagaca     2700

cgattcctca gaccagtgag caaaaggaat atgaaaacag agactataaa gatttcacaa     2760

aacaggacct gcctacggct gaacggagcc aggaggccac gtgtcccagc ccagcgtcca     2820

gtggtgcctc tcaagaaacc ccgaacgaat gttcggatga ctttggagag tttcaaagtg     2880

aaaagcccaa aatcagcaaa tttgacttct tagtagccac ttcacaaagc aaaatgaaat     2940

ccagtgaaga aatgatcaaa agtgagctgg caacctttga cctttctgtt caaggatcac     3000

acaagaggag tttgagcctt ggtgataaag aaataagccg ttcttctcct tctccagctt     3060

tggagcagcc tttcagagac cgttccaata ctctgaatga gaagcccgcc ctgcccgtca     3120

tccgagacaa gtacaaagac ctgacgggag aggtggagga aaatgagaga tatgcatatg     3180

aatggcagag atgcctgggg agtgccctga atgtcattaa gaaggcaaat gataccttaa     3240

atggaatcag tagtagttct gtttgcacag aagtaattca gtcagctcaa ggcatggaat     3300

atttattagg tgttgttgaa gtgtacaggg taaccaagcg tgtggagctg gggataaaag     3360

ccactgcagt gtgcagtgag aaactccagc agttgctgaa ggacatcgat aaagtatgga     3420

ataacctaat cggcttcatg tcactcgcca cactcacatg ctgctgggaa aagatgactg     3480

tgattacaaa gcatctctct ccttaccatg agctcttaga agaaaagcca gatgaaaact     3540

cgctggattt ttcctcctgt atgttacggc ctgggattaa aaatgctcag gagcttgcct     3600

gtggagtgtg cctcttgaat gtggactcga ggagccggaa agaagagaag cctgcagaag     3660

aacatcctaa aaaagcattc aactcagaaa cagacagttt caagctggcc tatggagggc     3720

accagtatca cgccagctgt gccaacttct ggatcaactg tgtcgaacca aagcctcctg     3780

gcctcgtcct gcctgacctg ctctgaacaa ctcctctgtg aagcattgac tttttttttt     3840

ctgtgacacc ccacggggt                                                  3859


<210> 2349
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 2349
ggtgtttgac ccggaagtgg ctgtgttcag ctgacagctg ctgataaggt ggcggcggcg       60

aaggcagcgg caggtcggga gcaagatggc gctgcggcca ggagctggtt ctggtggcgg      120

cggggccgcg ggagctggcg cggggtccgc cgggggaggc ggcttcatgt ttcctgttgc      180

aggtgggata agaccccctc aagcaggcct gatgccgatg cagcaacaag gatttcctat      240

ggtctctgtc atgcagccta atatgcaagg cattatggga atgaattaca gctctcagat      300

gtcccaagga cctattgcta tgcaggcagg aataccaatg ggaccaatgc cagcagcggg      360

aatgccttac ctaggacaag cacccttcct gggcatgcgt cctccaggcc cacagtacac      420

tccagacatg cagaagcagt ttgccgaaga gcagcagaaa cgatttgaac agcagcaaaa      480

actcttagaa gaagaaagaa aaagacgcca gtttgaagag cagaagcaaa agctcagact      540

tttgagcagt gtgaaaccca agacaggaga gaagagtaga gatgatgctt tggaagccat      600

aaaaggaaat ttagatgggt tttccagaga tgcaaaaatg caccctactc cagcatcgca      660

ccccaagaaa ccagattgcc ccacatcatc tcattctact aaaactgtct ccccatcacc      720

tgcctttctt gatgaagaag aattcagtga ctttatgcag gggcctgttg aagttccccc      780

atgtgggcct tcttccacgt cccagccctt tcagtctttc cacccctcca ccccacttgg      840

ccagttgcat acacagaagg ctgggacaca gcctctccct ccaagtcaga gtccagtgcc      900

ttttgcctta catggcgtcc ctgggcaaat tccttacttc tctactgctt cagcctcaca      960

cagtgtacca gaagcaggcc cttccttgga ggagaagttc ctagtatctt gtgatataag     1020

tacatctggg caggaacaaa ttaaattaaa tacttctgaa gttggccaca aagccctagg     1080

cccaggttcc agtaagaagt atcccagttt aatggccagt aacggggttg ctgtagatgg     1140

atgtgtgtgg gagtatttcc ctcacaggat cctgctcagc ccagaatgcc tccttggatt     1200

tacaatgaga gtttggttcc agatgcctat aagaaaatct tagaaaccac aatgactcca     1260

actggaatag atactgccaa actgtatccc attctgatgt catctgggct tcccagggaa     1320

actcttggac agatatgggc cttagctaat cgaactacac ctggcaaact tacaaaa        1377


<210> 2350
<211> 2181
<212> DNA
<213> Homo sapiens

<400> 2350
cagataccgc cgccgccgcc attttggaag cgggcacgtc gcccacggcg acgcgaccgg       60

tagctacggg accacggccc taaggagggc ggaagtcgtc gctccgtgga gcctcctcct      120

ctcgcgagag gcgcaaggcg tggagtcgac ggctggagag aagccgggag cgagcccagg      180

cggcagtctt gattcccttt tggccagcag tttttaggtc tgtcagtact gcactgcaag      240

aatggcagat tttgggatct ctgctggcca gtttgtggca gtggtctggg ataagtcatc      300

cccagtggag gctctgaaag gtctggtgga taagcttcaa gcgttaaccg gcaatgaggg      360

ccgcgtgtct gtggaaaaca tcaagcagct gttgcaatct gcccacaaag aatccagctt      420

tgacattatt ttgtcaggtt tagtcccagg aagcaccact ctgcacagtg ctgagatttt      480

ggctgaaatc gcccggatcc ttcggcctgg tggatgtctt tttctgaagg agccagtaga      540

gacagctgta gataacaata gcaaagtgaa gacagcatct aagctgtgtt cagccctgac      600

tctttctggt cttgtggaag tgaaagagct gcagcgggag cccctaaccc ctgaggaagt      660

acagtctgtt cgagaacacc ttggtcatga aagtgacaac ctgctgtttg ttcagatcac      720

aggcaaaaaa ccaaactttg aagtgggttc ttctaggcag cttaagcttt ccatcaccaa      780

gaagtcttct ccttcagtga aacctgctgt ggaccctgct gctgccaagc tgtggaccct      840

ctcagccaac gatatggagg acgacagcat ggatctcatt gactcagatg agctgctgga      900

tccagaagat ttgaagaagc cagatccagc ttccctgcgg gctgcttctt gtggggaagg      960

gaaaaagagg aaggcctgta agaactgcac ctgtggcctt gccgaagaac tggaaaaaga     1020

gaagtcaagg gaacagatga gctcccaacc caagtcagct tgtggaaact gctacctggg     1080

cgatgccttc cgctgtgcca gctgccccta ccttgggatg ccagccttca aacctgggga     1140

aaaggtgctt ctgagtgata gcaatcttca tgatgcctag gaggttcctg acatgggacc     1200

catctgctcc tccagccaac tcctgtccct cacatcccac catggtggct cctcccacct     1260

cctctggatt tgttcactct gagatctgtt tgcagagtgg gtgcttagca gacagagtga     1320

agctggctgg ggggcacagt ggtgtgtagt gctgctgtgt atcaaaagac caaggtatta     1380

tgggacctgg tttcagaatg ggatgggttt cttcacctca tgttaagaga agggagtgtg     1440

tcctgaagaa gcccttcttc tgatgttaaa atgctgacca gaacgctctt gagcccaggc     1500

atcgttgagc attaacactc tgtgacagag ctgcagaccc ctgccttgag tctcatctca     1560

gcaatgctgc caccctcttg tctttcagag ttgttagttt actccattct ttgtgacacg     1620

agtcaagtgg ctcacaacct cctcagggca ccagaggact cactcactgg ttgctgtgat     1680

gatatccagt gtccctctgc ccccttccat ccccaaccac atttgactgt agcattgcat     1740

ctgtgtcctg ttgtcattta tgttaacctt caggtattaa acttgctgca tatcttgaca     1800

tatcttgaga ttctgcatgt cttgtaaaga gaggggatgt gcatttgtgt gtgatgttgg     1860

atagtcatcc acgctcagtt tggaccattg gaggaactta gtgtcacgca caaatggggc     1920

tattcctacg cttagaatag ggcttgtctg cccactttag aagagtccag gttggtgagc     1980

atttagaggg aagcagggca gaactctgaa cgacaatacg tctctctgag cagagacccc     2040

tttgttcttg ttatccaccc atatggactt ggaatcaatc ttgccaaata tttggagaga     2100

ttgtgtggat ttaagagacc tggattttta tattttacca gtaaataaaa gttttcattg     2160

atatctgtcc ttgaaacttg a                                               2181


<210> 2351
<211> 1316
<212> DNA
<213> Homo sapiens

<400> 2351
tagatagggg ttttcattta ggccttgcga catggctgtt acatgacctt ggttggtctg       60

tttccctaac ctctttgtgc ctcatttgtc ttacctacta aataggctaa tagtactacc      120

tcgcagcatg aagatgattt taataagatg aatgagagta acgactcgac aaactatgac      180

atggctcctt actatgaagc cttgtgcaaa tccctcgact ggcagataga cgtggaccta      240

ctcaataaaa tgaagaaggc aaatgaagat gagttgaagc gtttggatga ggagctggaa      300

gatgcagaga agaatctagg agagagcgaa attcgcgatg caatgatggc aaaggccgag      360

tacctctgcc ggataggtga caaagaggga gctctgacag cctttcgcaa gacatatgac      420

aaaactgtgg ccctgggtca ccgattggat attgtattct atctccttag gattggctta      480

ttttatatgg ataatgatct catcacacga aacacagaaa aggccaaaag cttaatagaa      540

gaaggaggag actgggacag gagaaaccgc ctaaaagtgt atcagggtct ttattgtgtg      600

gctattcgtg atttcaaaca ggcagctgaa ctcttccttg acactgtttc aacatttaca      660

tcctatgaac tcatggatta taaaacattt gtgacttata ctgtctatgt cagtatgatt      720

gccttagaaa gaccagatct cagggaaaag gtcattaaag gagcagagat tcttgaagtg      780

ttgcacagtc ttccagcagt tcggcagtat ctgttttcac tctatgaatg ccgttactct      840

gttttcttcc aatcattagc ggttgtggaa caggaaatga aaaaggactg gctttttgcc      900

cctcattatc gatactatgt aagagaaatg agaattcatg catacagtca gctgctggaa      960

tcatataggt cattaaccct tggctatatg gcagaagcgt ttggtgttgg tgtggaattc     1020

attgatcagg aactgtccag gtttattgct gccgggagac tacactgcaa aatagataaa     1080

gtgaatgaaa tagtagaaac caacagacct gatagcaaga actggcagta ccaagaaact     1140

atcaagaaag gagatctgct actaaacaga gttcaaaaac tttccagagt aattaatatg     1200

taaagccatg taactaacaa aggatttgct ttagagataa ttatttggaa tttttatagc     1260

ttacttcaca atgtgcccag gtcagctgta taaaataaat actgcattgt tgtttc         1316


<210> 2352
<211> 2922
<212> DNA
<213> Homo sapiens

<400> 2352
ccacgccgcc atggccaagt ggggccaggg gaacccccac tggatcgtgg aggagcggga       60

ggacgggacc aacgtgaaca actggcgctg gcgcggctgg cggcggcctc cttccgggat      120

ctggggaggg ccgggccgcg ggagccgggg ctgccctggg gtctgtgcgg ggccgcgggg      180

ccagggggtc agggggccgc cccccctcag ctgctggacg cagggctcgg ccttcgcctc      240

tcggctcggg agagtccttg agtacggaga ccggctagga gggttgcagc tgcctctttt      300

tgaaagttgg gttgggcccc aagagtgact tccgacagac ctttccactc ccaccgtctg      360

tggcctgagg gccttccctt ctcctcccgc ccacccctct ggatgtttcg gggagttaga      420

agggagctgg attgagagac tgtgttaggg gcgggggtat ggaacgtagt ggaaagggca      480

gaaatttgga tctcagttcg cgcccacccc gcaggcgcct cccgcgagcc gggccctctg      540

tgagtgagac aagctcccct tcctttacgc gcctcacctg gcgcgtgggg agaggtcggc      600

agccctccgc cgcagaacct ccggaaggga tgtcctctgc cctgcgcctc tggccggggc      660

tgtggtccct ccaggccgtc gaggggatgc tgaggccggt ccccagagga gcatgacttg      720

gctggtccgg aggagctctg agggcatggg caatcttggc tcgctgcaac ctcagcttcc      780

agagttcaag cgagtctcct gcttcagcct catgagtagc tgggactaca gatgcgtgcc      840

actacgtccg tctgatgttt gtatttttag tagagacagg gtttcaccat gttggtcagg      900

ctgctctcga actccagatc tcgtgatccg cccgcctggg cctactaaag tgctgggatt      960

acaggcgtga gctagatctg actttctagt gtcctagcct tggcccgatg gacatgtcat     1020

ttctctcagc tcgtttctgt cccctaaagt gagaatattg cctgggaaga ttacattaga     1080

cgatgtatat gcgaagacac ttgatagctg gtattgtcat gattctgatt agttcactac     1140

tgctactttc cctgtggcct aggctttgcc tatttccagt gggcgagcta gctagatcct     1200

cctcccttaa ataagccagt gtttttaaga cagaatacta cttgcatagt ggacaataat     1260

atcttaaaga actgagcagg atgaaaagaa tttgatagaa agcaggtttg aggagcacat     1320

tggaggttgg caggtttcga ggctgcttga gaggacttgg gccgatctgg gctgggcttg     1380

gacgtgaccc tggcacccag gcaggtggat cccagctggg gcttccattc acgactttct     1440

ggtccctggc aggacagagc gggatgccac cagcttgtcc aaagggaagt tccaggagct     1500

cctggtgggc atcgttgtgg agaatgacgc tggccgcggc gagatcaacg agttgaagca     1560

ggtggaaggg gaggcttcgt gcagcagccg caaaggaaag ctgattttct tctatgagtg     1620

gaacatcaaa ctgggctgga aaggcatcgt taaagaatct ggagtgaagc acaagggatt     1680

gattgaaata cccaatcttt ctgaggaaaa tgaagtagat gacactgaga atttacaacg     1740

ggaatgattt taccaacgaa agctatggca acccaggaat tgactgtcaa aagaaaactg     1800

agtgggaata ccctgcaggt tcaggcctca tctccagtgg cactgggtgt aaggattccc     1860

actgtggctc ttcacatgat ggaactgttt gacacaactg tagagcagct gtatagcatc     1920

ttcactgtaa aggagttaac aaataagaag atcatcatga aatggagatg tgggaactgg     1980

ccagaagaac actatgccat ggttgcactg aattttgtgc ctactctagg gcaaacagaa     2040

ttacaattga aggagttcct atctatctgt aaagaagaga acatgaaatt ctgttggcag     2100

aagcagcatt ttgaagaaat aaaaggttca ctgcagctga cccccctaaa tggttgaatt     2160

aaaatttatt ataaggcatt actttttgta agcggaaaaa gtgtcacatt tacctcttcc     2220

ctatcttttg tttaaaagga ctgtctttat tttatattgg atgaaatcta tgaacatata     2280

tacaatgtaa agcattgttt gactctttat tataactaga cactgcattg atttaaaagt     2340

agcaaacaac ctgaaattaa gtattaacct gaccttccat cgatattcct ctggaaatag     2400

gtaagtcctg agtgcagata gttgatgttt cccaagctga agcttgtcct atagcaagct     2460

tgcttgcagc tgtactttta gttcaagatg acaaaaaata aatggcatgt tgacactatt     2520

cctttatttt actttagggt ttttaaggtg tgtagatctt aggtcgtaaa acagtggtat     2580

attgcattca aaagcatgtt gaggtgaggg caaattggct gtgttttgct ccacatctcc     2640

ctgcacatct ccctgctgtg gttttgcact tcggtgtgga gaggattgag aagtctgtgg     2700

ggacacatta gttctgtgga ctgctggtaa cacttccagt gaaacagcat ataatggata     2760

aatgtttccc ccctctttca cggttttctc actactttca cctgagaaga ctgaagcaac     2820

gtatgtaaac aaatgaaaag tcatcacaat cagtttaatt aagtgcacag aatagcaatc     2880

aatcaatcag tcatgtcaat aaaaataaaa caattatttt ta                        2922


<210> 2353
<211> 6029
<212> DNA
<213> Homo sapiens

<400> 2353
agactgaggc tggctggctg gaggttgaca caggagtgct caggggagca gcatcacaag       60

agggcagatc gaaagcatcg tccttgctga aaaagtgagc atgggcctgg ggtgtgccct      120

ggactgggga gggagacggc aaacttctaa gacctgcaat gagagttcag gcctttggca      180

caaactaagc agcttcgcct gctcaggctg ggagggacag agagtgaggc acagggactc      240

tcaacttggg ccaagctctg agcaaatgct ataatgtcct catggggcaa tagatttggg      300

ggttctgggg gtgggtccct tccaggcaga atccccacca tcctctctgg tgtgagggga      360

ccctggagct ccggacctca ggccaggagc ccagccctgg gtctgcagtg aggggctgac      420

cagacagagc ttctcctgtc ccagcagatg gcagaggtgg aagcggtaca gctgaaggag      480

gaaggaaacc ggcatttcca gctccaggac tacaaggccg ccacaaatag ctacagccag      540

gccctgaagc tgaccaagga caaggccctg ctggccacgc tttatcggaa ccgggcagcc      600

tgtggcctga aaacggagag ctacgtccag gcagcttcag atgcctccag agccatcgac      660

atcaactcct cggacatcaa ggctctgtat cggcgatgcc aggcactgga gcacctgggg      720

aagctggacc aggccttcaa agacgtgcag cgttgtgcca ccctcgagcc acggaaccag      780

aacttccagg agatgctgag gagactcaac accagcattc aggagaagct ccgagtgcag      840

ttctccacag actcgagggt acagaagatg tttgagatcc tcttggatga aaacagtgag      900

gctgataagc gggaaaaggc tgccaacaat ctcattgtcc taggccgtga ggaagcaggg      960

gctgagaaga tcttccagaa caatggagta gccttgctac tgcagcttct ggacactaag     1020

aagcctgagc tggtgctggc tgcagtgcgg accctgtcgg gcatgtgcag cggccaccaa     1080

gccagagcca cagtgattct gcatgcagtg cggatagacc gaatctgtag cctcatggcc     1140

gtggagaatg aggagatgtc tctggctgtc tgcaacctgc tccaagccat cattgactcc     1200

ttgtctgggg aggacaagcg ggagcatcga gggaaggagg aggccctggt tctagacacc     1260

aagaaggacc tgaagcagat caccagccac ctgctggaca tgctagtcag caagaaggtg     1320

tctggccagg gcagggatca ggcgctgaac ctgctcaata agaatgttcc caggaaggac     1380

cttgccattc atgacaactc acgtaccatc tatgtggtgg ataatggtct gaggaagatc     1440

ctgaaggttg tggggcaggt tccagatctg ccatcctgcc tgcccctgac tgacaacacc     1500

cgcatgctgg cctctatcct catcaacaag ctctatgatg acctgcgctg tgacccggag     1560

cgcgatcact tccgcaagat ctgtgaggaa tatatcacgg gcaagtttga cccccaggac     1620

atggacaaga acttgaatgc catccagaca gtgtcaggga tcctgcaggg cccctttgac     1680

ctgggcaacc agctgctggg actgaaaggt gtgatggaga tgatggtggc actatgtggc     1740

tcagagcgcg agacggacca gctggtggcc gtggaggccc tcatccatgc ctccacgaag     1800

ctcagccgcg ccaccttcat catcaccaat ggagtgtcac tgctcaaaca gatctacaag     1860

accaccaaaa atgagaagat caagatccgc acactggtgg gactctgtaa gctcggctct     1920

gcaggtggca cagactacgg tctcaggcag tttgcggaag ggtcgacaga aaaactggcc     1980

aaacagtgtc gcaagtggct gtgcaatatg tccatagaca ctcggacccg acgctgggca     2040

gtggagggcc tggcctacct cacgctggac gctgatgtga aggacgactt tgtccaggac     2100

gtccctgccc tgcaggccat gtttgagctg gccaaggcag gtaccagtga caagaccatc     2160

ctgtactcgg tggccaccac cctggtgaac tgcaccaaca gctacgatgt caaggaggtc     2220

atcccagagc ttgtccagct cgccaagttc tccaagcagc atgtgcccga ggaacacccc     2280

aaggacaaga aggactttat agacatgcgg gtgaagcggc ttctgaaggc gggtgtcatc     2340

tctgccctgg cttgcatggt gaaagcagat agtgccatcc tcactgacca gaccaaggag     2400

ctgctggcca gggtattcct ggcactgtgt gacaacccaa aggaccgagg caccattgtg     2460

gctcaaggtg gtggcaaggc cctgattccc ctggctttgg agggcacaga tgtgggcaag     2520

gtgaaggcag cccacgctct agcaaagatc gctgctgtct ccaatccgga cattgctttt     2580

cctggggagc gggtgtatga ggtggtgcgg ccccttgtaa gactcttgga cacacagagg     2640

gatgggcttc agaactatga ggctctccta ggcctcacca acctgtctgg gcggagtgac     2700

aaactccggc agaagatctt taaggagagg gccttgccag acatcgagaa ctacatgttt     2760

gagaatcatg atcagctgcg gcaggcggcc accgagtgca tgtgcaacat ggtgctccac     2820

aaggaggtac aggaaaggtt cttggctgac gggaatgacc ggctgaagct ggtggtgctg     2880

ctctgcgggg aggatgatga taaggtgcag aatgcggctg caggggctct ggccatgctg     2940

acagcagcac acaagaaact gtgcctcaag atgactcaag tgacaaccca gtggttggag     3000

atcctccagc ggctttgcct gcacgaccag ctgtctgtcc aacaccgggg cctggtcatt     3060

gcctacaacc tactggcagc cgatgctgag ctggccaaga agctggtgga gagtgagctg     3120

ctggagatcc tgactgtggt gggcaaacag gagccagatg agaagaaggc agaagtggtt     3180

cagacagccc gagaatgtct catcaagtgc atggattatg gtttcattaa accagtgtct     3240

tagacagcga ccctcaggga tgctgggagt ggtcctgtac tgtgcagagt cctgggttgg     3300

ttgggttctc ctgaagagtc aggtcatcta gggatcatag cagtgacaat gaagtctcaa     3360

tataaaggaa agacttgatt gttctctgag ttgtgagtct tctcctttgt cctgacagag     3420

tttggatgtt tcactctctc tcttgcttcc tgtctcctta tatttgtcat gtttcagaaa     3480

ttcccagaat aattttcacc catgattaga aataggttgg atcattcttt ctgtacccat     3540

tctgaaggcc aggataatag gttgaagttc tttatatttt ggaaaatgga ttttgtggta     3600

aggtaggaac taacgggtgt gtgcatataa aggttaatgc tgttgtattt ggatgctgat     3660

ctgtgctgtt ttcatgacct ctctcccaca ctatttgaat cagtctgttc agaactgtgt     3720

gtttcacctg cagtgctctg tcccagtccc atgcccattc ccatcacttc actgtgatgg     3780

aaatagagtt tatgttcaac agtggggcat gacctctgca atttgcttgg gaaagtcttc     3840

caagcaagat ggacatgatg aatacaaata agatctactc aaagtacttc aaacaaaaaa     3900

taaataattc attggctcat gtatcttggc cacccaggga aggtctgaca ttgttagtta     3960

gatccagagt ttcaaatgtc atcaccatgg atgtgtcttt ttctctctct catttcccct     4020

ccccatatct tgtcttttat ttattatagg tttgtctcat tccctggcag gctctctccc     4080

tgtgatagga aagagagtcc ccagcagccc cagggtgaca tagttgttat agttcattat     4140

ggaatagaag agagaagagc attctcaata acccggcaaa gttcccaggg atgactctga     4200

tatgtctatg tctcaggtca catttccatc tatgaaccaa tcatattcag aggtggaatg     4260

ctaattggcc aggcctgggt catatataca agtctaggga agaaatgagc ttcatccctg     4320

tccaattgac atggactgat taggggtatt aatggaagag gtgtgccacc acaaaagaat     4380

gtaccctggg cagatcaaag aacatattct gtatgtcagg cttggccaca aaagaatgac     4440

acaagtaata tgctgtagat cagaacctct ctgctaatat tgccttttta gcatggttaa     4500

gatagctaag atctagtact gtcactccag tatgtcccaa ttctacctac gtttattgaa     4560

gggtcaacag ttctgatctc agcattgggt aaagggtggg acattcagat ttacggtcct     4620

tgataaaaac aatttacaac gttccgttgt gtaataaatg taagtgtaca tatgcctggg     4680

acatcagctg gaaaagggac agactatcag agagttgcac tgttgcggta tgggccaaat     4740

ccaacataat acccgctgta cctctagaga actaaaacct taatttctca gatcttttct     4800

gcactaatgg tctttacata cagcctacat tttaactaac tcttgcatgg gcttgtttca     4860

cagcaggaaa ctatattcat catatcctta ttatgataga gaatgacaac attcaaaagg     4920

gtgtggtgct tctgaaaata tacacaataa atggcatgat ttgacctctg tcaaattctt     4980

ctttcctgct ttcctcatat gtgggcttga gtgggtgtat ttagctcctt taaaggaaac     5040

tctttcacag gcagggccac actcttactc gttttgatct catgaggtta catctgccag     5100

tggcgttcag ggccagttag ataaagttca tcttgtttgg attggagaga cttttttttt     5160

tttttttttt gagacagggt cttgctctgt aacctaggct caagtgcagt gcagtggtgc     5220

agtcatggct caccgcagcc ttggtctcct gggctcaagt gatctttcta cttcagcctc     5280

ctcaatagct gggactacag gcacacacca ccacccccag gtaattaaaa aatttttttt     5340

tgtagagaca gggtctcact atgttgccca gtctgggaga ccacattctt taacatgaat     5400

attttgtaaa tagtccaaga agatctagag gaaagctgaa ttccttcatc tgatttttgc     5460

cactgggctg cctcccattg tctggctaag tcttcatggg aggcctttaa gaaaagctgt     5520

gacaaatacc tttgtttccc actgcctagg ttacataagt agttggcttt tccagcctag     5580

actcttatat tgttgcttgt aagagggccc ttctttgcag atttcttttt tttttcatct     5640

atgctttcaa ataggcagat gctagcctga gatcatctct ttattgaggt agtttgccca     5700

aaaacagcaa ggaacagcca atacctgcca actttctagg tttttccaac caattctctt     5760

acagaaaatc tataaatatc ttagaggtat gtttcttagt ttcccaacat ataatgggaa     5820

aattcatcat ttatattatt acttttaact gaagtatgtt gttatcagag aacttggtct     5880

gtgtcatatt aatcctttgc catttgagaa gcatacagtt ttaaagttta tatctccaaa     5940

aggatatttt gtaaaaattt aacccctttg actcttagtc ttctcatttg tgaaaggtaa     6000

ataataaaga atttctgttc ctagtaaga                                       6029


<210> 2354
<211> 533
<212> DNA
<213> Homo sapiens

<400> 2354
gtttcccgca ctgccggtat ccgccgccat ccggactccc gggtcctctg tgcaggttgg       60

aggatggttg gttgtggcga gcgaggctga aggagccggg acgcggggct ctgggcctcg      120

ggaactgagc cggtactcac ctccgcccct tctccccgtc gctgtccgca gccatggccc      180

tacgctaccc tatggccgtg ggcctcaaca agggccacaa agtgaccaag aacgtgagca      240

agcccaggca cagccgacgc cgcgggcgtc tgaccaaaca caccaagttc gtgcgggaca      300

tgattcggga ggtgtgtggc tttgccccgt acgagcggcg cgccatggag ttactgaagg      360

tctccaagga caaacgggcc ctcaaattta tcaagaaaag ggtggggacg cacatccgcg      420

ccaagaggaa gcgggaggag ctgagcaacg tactggccgc catgaggaaa gctgctgcca      480

agaaagactg agcccctccc ctgccctctc cctgaaataa agaacagctt gac             533


<210> 2355
<211> 2196
<212> DNA
<213> Homo sapiens

<400> 2355
ttcatggctc tcgggtagaa cctagtgaaa cggccagaat gaattctatg gacaggcaca       60

tccagcagac caatgaccga ctgcagtgca tcaagcagca cttacagaat cctgccaact      120

tccacaatgc cgccacggag ctgctggact ggtgcggaga cccacgggcc ttccagcggc      180

ccttcgagca gagcctgatg ggctgtttga cggtggtcag tcgggtggca gcccagcaag      240

gctttgacct ggacctcggc tacagactgc tggctgtgtg tgctgcaaac cgagacaagt      300

tcaccccgaa gtctgccgcc ttgttgtcct cctggtgcga agagctcggc cgcctgctgc      360

tgctccgaca tcagaagagc cgccagagcg atccccctgg gaaactcccc atgcagcccc      420

ctctcagctc catgagctcc atgaaaccca ctctgtcgca cagtgatggg tcgttcccct      480

atgactctgt cccttggctg ccagcctacc ctgcctgcac tcctccacca tcacaatctc      540

acccaaactc ctgctcactc aagcaaaagc agcctctggc cttccctcca ccgctttgct      600

ccatctggct taccactctc cagggcctcc tggggagcct gtcctgtgtt cactttgttt      660

caggctggtc tgtgccccgt gagccacatg gcctagggtg atgccaggtt gtcccgtcac      720

tggggtccca tctgtaaatt ctttgcgccc ttcccggctg ctgcctgggg ccctttcctg      780

ctctcccgtc cgctgtgggt ggtccccagc tctcctctgt gggttttacc ggaaaggtgg      840

ccccagctgt tgacttccag tcactgtccc agacggcaca aggttttctg taggaaagct      900

gccattgccc cggccccttt tcttcctttg tcccgttgtc gaggtttttt caaatagcgt      960

gttgttcagt atgcaaatca attattttaa gaatcgcttt tgtaaatatc tttgtgaata     1020

ttttagtatc gtctttgata atattcaaca ttttcatgac ctggttatag cctttgctgg     1080

tgtttttaaa atacctggac tcaatgacaa agaccgagtc ttcttttttt ttaaacaaaa     1140

acaaaaaaag caaccagggc tatttgtaca gttgaagggg tgaacagaat gggcggctgt     1200

gctgggagtt ggaagaccgg gcagcccgct atttagagcc atccctcagt cagctggcag     1260

ggacaagcca acgccaggta gcatgtggcc acccttgccc agtgtctgtg gcctggcaag     1320

tggccacgcc ctgtgtcaga ccatctggga attaagctcc agacagactt acagatgcct     1380

tccttaggag ttcttgcttc ttgcgttgat actttgcccc agaaaggcct gggattcatt     1440

ctggttctta tcagggtgtg tccacactct gctcacaggt ggatccacgg ctttccagtg     1500

cggagagtcg agatgctccc tgcagcccag gccccgggca cctcctgcaa ccatctctgg     1560

gctcagcacc tgaggcgggt ttcctgggtc ccctctccag caagcctcca ccagcaagct     1620

cggcccagag cttcccttcc ggctggctct gaaccgtgcg tggtgcctac agcctgcagt     1680

ctggagacaa gctcttccgg agtgctctgg gagccaggcc agggtgtgag ggaggtgcag     1740

aggcatccgg ggcgggagca agccccaggt tgtgacaggt gcaggtagac aacgcccata     1800

aacagagatg gtcctgaact ctggagagat ccttccctga tcctttcgga cgactacttg     1860

gagccataag taacctcagc aaaaacgagg cctctgcaag ccacttttcc atgccaagca     1920

tccacccggc ccacaggcat gtttctgccg ccactccgca agatggacag ggagccagca     1980

ggcaggcggg aagggccaag tacaggcaat cacccccatc ttcttggttt gaagctttat     2040

ccatgtatca tgttccgtgt agccatttta ttttttaaga aactgctaat actttctccc     2100

taatggaagc cctgatcccc cagagagcta caggtctgct cccgacgggc ctcgggcctg     2160

acccgtccac acagggccgt gtcaacagca gcgact                               2196


<210> 2356
<211> 529
<212> DNA
<213> Homo sapiens

<400> 2356
gttgtctgca ggtatggatg ttgttctctt ttccctgtct ttatttcctt accaatcggc       60

tgccatccga ggagctgagg aagcctagag ctctcagaag cagtcctttg agctggtgta      120

ggggcactca gaatggtcca gcgtttgaca taccgacgta ggctttccta caatacagcc      180

tctaacaaaa ctaggctgtc ccgaacccct ggtaatagaa ttgtttacct ttataccaag      240

aaggttggga aagcaccaaa atctgcatgt ggtgtgtgcc caggcagact tcgaggggtt      300

cgtgctgtaa gacctaaagt tcttatgaga ttgtccaaaa caaagaaaca tgtcagcagg      360

gcctatggtg gttccatgtg tgctaaatgt gttcgtgaca ggatcaagcg tgctttcctt      420

atcgaggagc agaaaatcgt tgtgaaagtg ttgaaggcac aagcacagag tcagaaagct      480

aaataaaaaa atgaaacttt tttgagtaat aaaaatgaaa agacgctgt                  529


<210> 2357
<211> 441
<212> DNA
<213> Homo sapiens

<400> 2357
cttttttctt cctcttccgg ggacgttgtc tgcaggcact cagaatggtc cagcgtttga       60

cataccgacg taggctttcc tacaatacag cctctaacaa aactaggctg tcccgaaccc      120

ctggtaatag aattgtttac ctttatacca agaaggttgg gaaagcacca aaatctgcat      180

gtggtgtgtg cccaggcaga cttcgagggg ttcgtgctgt aagacctaaa gttcttatga      240

gattgtccaa aacaaagaaa catgtcagca gggcctatgg tggttccatg tgtgctaaat      300

gtgttcgtga caggatcaag cgtgctttcc ttatcgagga gcagaaaatc gttgtgaaag      360

tgttgaaggc acaagcacag agtcagaaag ctaaataaaa aaatgaaact tttttgagta      420

ataaaaatga aaagacgctg t                                                441


<210> 2358
<211> 853
<212> DNA
<213> Homo sapiens

<400> 2358
ccgaggagct gaggaagcct agagctctca gaagcagtcc tttgagctgg tgtaggggca       60

ctcagaatgg tccagcgttt gacataccga cgtaggcttt cctacaatac agcctctaac      120

aaaactaggc tgtcccgaac ccctggtaat agaattgttt acctttatac caagaaggtt      180

gggaaagcac caaaatctgc atgtggtgtg tgcccaggca gacttcgagg ggttcgtgct      240

gtaagaccta aagttcttat gagattgtcc aaaacaaaga aacatgtcag cagggcctat      300

ggtggttcca tgtgtgctaa atgtgttcgt gacaggatca agcgtgcttt ccttatcgag      360

gagcagaaaa tcgttgtgaa agtgttgaag gcacaagcac agagtcagaa agctaaataa      420

aaaaatgaaa cttttttgag taataaaaat gaaaagacgc tgtccaatag aaaaagttgg      480

tgtgctggag ctacctcacc tcagcttgag agagccagtt gtgtgcatct ctttccagtt      540

ttgcatccag tgacgtctgc ttggcatctt gagattgtta tggtgagagt atttacacct      600

cagcaaatgc tgcaaaatcc tgttttcccc cagagagctg gaggttaaat actaccagca      660

catccctaga tactactcaa gttacagtat atgatcacta atatagtatg ctcttggtac      720

caggagctct gatatatatc tggtacatgt ttgataatga cttgattgtt attataagta      780

cttattaata cttcgattct gtaaagagtt tagggtttga ttttataaaa tccaaaatga      840

gccttttatt gaa                                                         853


<210> 2359
<211> 4049
<212> DNA
<213> Homo sapiens

<400> 2359
atgaaagcca taaagaaaag tcttacagaa gaagaatacc tgtacctgga cttttctcac       60

caaacagaag gatgcatctt tcctcttcat acatctgtaa ctttatttct gttatcttac      120

tgtgactgta aaatctttaa aatttgctta gttgtcacca aagaggtgag tagagatagt      180

tcactactaa gagatgacct gatccaggat gttgaaatac agattatttc aaggcaggag      240

ctcccaccaa tagtccaaaa ttgctgtttg cctgcagtag tagaacgatc agacaatttt      300

tgtagagcag gacttgctgt tgtattgaga cacataatcc agaaatccta tgaagcagac      360

cccttaaaga aggaactttt ggaacttctg ggctttaaaa agacttgctt gaaagcctgt      420

gctgaagtta gtcagtggac caggctatgt gaactcacca tccctttggc tattgagaat      480

tttctcagag aatcttctga ccagccccca actatacctg tagaaatact acagctagag      540

aaaaagctta gtgagcctgt tagagtgcat aatgatgata aactccgcag gcagaagctc      600

aagcaacaga aggctgatgg agttgggcct ccccttacta agggaaaggc aaagagcaag      660

gtccacacac aggaaacatc tgaagggttg gattcttcat ccaagagtct ggaactgaaa      720

gtggcattct caaagctcac agtacaggaa gaaccagcta ctaccaacag agagccttct      780

cacatcagaa aagcaaaagc ctccgacctt ccacctctgg agcatgtgtt tgcagaaggg      840

ctttacttca ctctggcaga tattgtgctc ttgccctgta tccatcattt cttggtaatt      900

atcagcagga aattttctga gaagctggta gaatttccat tgctagcctc ttggtaccag      960

aggattcagg aagtgccagg agtaaaaaca gcagcttcta agtgtgggat ccaatttctc     1020

catttaccaa agttgttgac aacctcaact gaacagcatc caaacttatg tgaagtccca     1080

ggtgtagaag agcaaagcga tcctttattt ataggaggac caagaccaac catggccaag     1140

ttaatggaaa agggcattga agtgatgttt tctccccacc cttgccctac ttggactctt     1200

gattggaatg ttctccctgc agcagtcagc ccaaaggaag gtaaaatgtc cagtgatcga     1260

gctttgagga agcagcaaca gttgaacaac cttgtctatg tggtaacaaa tcaggccaaa     1320

cctggtgaca gaattgtgga tttctgcagc ggtgggggcc atgttggaat tgtccttgct     1380

cacatgctgc catcatgtca ggttacatta atagaaaaca aggaattatc attaattcgt     1440

gctaagaaga gaagtgatga actgggttta agcaacattt ggttcattca agcaaatatg     1500

gaatatttta ctgggatgtt taatattgga gtagcattgc atgcttgtgg agtggcaaca     1560

gacatggtga ttgagcactg tatcaaaaca cgggcttcct tcgtcacatg cccttgctgt     1620

tatggtttca ttcagaacac ctcaaagttc aattttccaa aaagtgaaca attcaagaaa     1680

actttatcat acaaggaaca catgattctg tgcagatttg cagaccagac agctgtccag     1740

ctcccacccc aacgaaggct cataggaaaa cagtgcatgt gcttggtgga tctggatcga     1800

gcaagagctg cagaagaatg tggatactcc gttcaagtga tatccatgga gccagagagc     1860

tgctctccca aaaataacat gattgtggga gtccccattt aaaatgagat attcacattt     1920

gatattttgc catccgtctt cacgttggat gcccagtggc attcaggagg ttcttggcat     1980

aactaggaaa cagcattagc catcttgaac ctattgtgct caggaaggaa agcaacaggg     2040

aaatcttgga agtaaaggct ccctgcaaag catcacaaat gctttacaat gtgtgattaa     2100

aggactgctg gtttttatag tgagaatccc ctgaagtctc agctgccaaa agaataatac     2160

tagtggaggt tccatcacag gaataacaat ttccttctca cttcacaagc tcctctgatc     2220

ttgccaatgt gatgtttaat tcaaaacagc gcacttacag cctttatttt atacttattt     2280

agatattcac atgggaactg aaagtagact cagtggagtt ttttgttttt tatattttta     2340

acaattgtac tttttctatc actttaaaaa aatctagtca ggtaattata gtacagttat     2400

ttttaagctg gggttagttg aacttgtata gcatttaata tactcctttt aaatatattt     2460

ctgccaggca tggtggctca tgcctataat cccagcactt tgagaggcca aggtgggagg     2520

atcatttgag cccaggatat cgagaccagc ctgcactaca aaaaaatcca aaaaatgagg     2580

tgggaggatc acttgagccc aggaagtcaa ggctgcagtg agccttgata gcgccactgc     2640

actcctgcct gggaaaatga gacccagact caaaataaat caatgaatga attaataaac     2700

aaataaataa ataaataaat ttcccataaa ttaccaaatg agattgtcac tggttcaaat     2760

tattaaataa ttgccataaa tttcctatta cgggaatgtg gaatttggac atacatttta     2820

acaataagta cattgattaa tacatttaag tttataagta attattgagg atccagtatt     2880

ttcaagacct tggcctagtt tcttttcaat tcaaagatga gttgcaaaag acataatgtt     2940

ttgcctatgg aagtagatca tctagaagaa aaagattaaa gaattagtta agcttttttt     3000

tttttttttt tttgagacag agtttcactc ttgttgccca ggctggaatt cagtggctcg     3060

atcttggctc accacaacct ctgcattctc ctgcctcagc ctcccgagta gctaggatta     3120

taggcacctg ccaccatgcc cggctaattt tgtttgtaat tttagtagag atggggtttc     3180

tccatgttgg ccaggctggt ttcgaactcc tgacctcagg tgatctaccc gcctcagcct     3240

cccaaagtgc tgaaattaca ggcgtgagcc acctcacctg gccatgttct ttatggaata     3300

ctacaatgtg ttgtcacagg atttgttatt cagatgtcaa tcatttttat ttatatattt     3360

ctgggtaaaa cttattagtg gtgtgaggag tgcagaatat ggaagcttac ctaaattctt     3420

tttctgccag ccaacatttt aaaagacaaa tgatgcatcc tttctcaatg ctgctaattc     3480

tttaaatttt acatgtccca atttattcca tttgagattt attttaatgt tttcaacccc     3540

tgtgtaacat gtatcatgag gagaaagcac tatcattgat catcactatg gattaaaata     3600

taggaatatt ttacagggca gtatgggtgg gggtgggaga catattggaa tcgtgttttc     3660

tgggataaaa tttttaaaaa gaattaatca ttagccctga gtattttagt catttgtgcc     3720

tatagaaaac aacatgctct tttattgtgg actttcttct tttaagtgag gtttaattta     3780

tatacaatac aataacagat ttttaagtat tcatttgaga tgttttgaca actgtatata     3840

tacatgtaac catcactgga atcagatata gaatattccc cttaaatatt gtcaggtaaa     3900

cacattgaga atattttttc cagtctgtgg cttacctact tattttcata atgaatgttt     3960

tacttgtgat gaagatttaa cttacccttt tactttaatg attaatattt tctgtgttct     4020

ttctaataaa ttttacgaac tctgaggtt                                       4049


<210> 2360
<211> 4043
<212> DNA
<213> Homo sapiens

<400> 2360
gttacttccc tttttccggt ccgccggatt atgaatgacg gccggcgcga gtattttcca       60

cataaggtgg ctgtcgtttt tctcctggcg tctgtggagg cgagtggtct gcgggcagca      120

gctcccagag gcagccttgg aattccagct cggactgggc gggaaggcgc aggcggccca      180

ggtcgccgac acgctcacgc accctccctg cctggccgcg cctctgcgac caggtgaccc      240

aatgaaagaa gaaaatgaaa gccataaaga aaagtcttac agaagaagaa tacctgtacc      300

tggacttttc tcaccaaaca gaaggatgca tctttcctct tcatacatct gtaactttat      360

ttctgttatc ttactgtgac tgtaaaatct ttaaaatttg cttagttgtc accaaagagg      420

ttagtcagtg gaccaggcta tgtgaactca ccatcccttt ggctattgag aattttctca      480

gagaatcttc tgaccagccc ccaactatac ctgtagaaat actacagcta gagaaaaagc      540

ttagtgagcc tgttagagtg cataatgatg ataaactccg caggcagaag ctcaagcaac      600

agaaggctga tggagttggg cctcccctta ctaagggaaa ggcaaagagc aaggtccaca      660

cacaggaaac atctgaaggg ttggattctt catccaagag tctggaactg aaagtggcat      720

tctcaaagct cacagtacag gaagaaccag ctactaccaa cagagagcct tctcacatca      780

gaaaagcaaa agcctccgac cttccacctc tggagcatgt gtttgcagaa gggctttact      840

tcactctggc agatattgtg ctcttgccct gtatccatca tttcttggta attatcagca      900

ggaaattttc tgagaagctg gtagaatttc cattgctagc ctcttggtac cagaggattc      960

aggaagtgcc aggagtaaaa acagcagctt ctaagtgtgg gatccaattt ctccatttac     1020

caaagttgtt gacaacctca actgaacagc atccaaactt atgtgaagtc ccaggtgtag     1080

aagagcaaag cgatccttta tttataggag gaccaagacc aaccatggcc aagttaatgg     1140

aaaagggcat tgaagtgatg ttttctcccc acccttgccc tacttggact cttgattgga     1200

atgttctccc tgcagcagtc agcccaaagg aaggtaaaat gtccagtgat cgagctttga     1260

ggaagcagca acagttgaac aaccttgtct atgtggtaac aaatcaggcc aaacctggtg     1320

acagaattgt ggatttctgc agcggtgggg gccatgttgg aattgtcctt gctcacatgc     1380

tgccatcatg tcaggttaca ttaatagaaa acaaggaatt atcattaatt cgtgctaaga     1440

agagaagtga tgaactgggt ttaagcaaca tttggttcat tcaagcaaat atggaatatt     1500

ttactgggat gtttaatatt ggagtagcat tgcatgcttg tggagtggca acagacatgg     1560

tgattgagca ctgtatcaaa acacgggctt ccttcgtcac atgcccttgc tgttatggtt     1620

tcattcagaa cacctcaaag ttcaattttc caaaaagtga acaattcaag aaaactttat     1680

catacaagga acacatgatt ctgtgcagat ttgcagacca gacagctgtc cagctcccac     1740

cccaacgaag gctcatagga aaacagtgca tgtgcttggt ggatctggat cgagcaagag     1800

ctgcagaaga atgtggatac tccgttcaag tgatatccat ggagccagag agctgctctc     1860

ccaaaaataa catgattgtg ggagtcccca tttaaaatga gatattcaca tttgatattt     1920

tgccatccgt cttcacgttg gatgcccagt ggcattcagg aggttcttgg cataactagg     1980

aaacagcatt agccatcttg aacctattgt gctcaggaag gaaagcaaca gggaaatctt     2040

ggaagtaaag gctccctgca aagcatcaca aatgctttac aatgtgtgat taaaggactg     2100

ctggttttta tagtgagaat cccctgaagt ctcagctgcc aaaagaataa tactagtgga     2160

ggttccatca caggaataac aatttccttc tcacttcaca agctcctctg atcttgccaa     2220

tgtgatgttt aattcaaaac agcgcactta cagcctttat tttatactta tttagatatt     2280

cacatgggaa ctgaaagtag actcagtgga gttttttgtt ttttatattt ttaacaattg     2340

tactttttct atcactttaa aaaaatctag tcaggtaatt atagtacagt tatttttaag     2400

ctggggttag ttgaacttgt atagcattta atatactcct tttaaatata tttctgccag     2460

gcatggtggc tcatgcctat aatcccagca ctttgagagg ccaaggtggg aggatcattt     2520

gagcccagga tatcgagacc agcctgcact acaaaaaaat ccaaaaaatg aggtgggagg     2580

atcacttgag cccaggaagt caaggctgca gtgagccttg atagcgccac tgcactcctg     2640

cctgggaaaa tgagacccag actcaaaata aatcaatgaa tgaattaata aacaaataaa     2700

taaataaata aatttcccat aaattaccaa atgagattgt cactggttca aattattaaa     2760

taattgccat aaatttccta ttacgggaat gtggaatttg gacatacatt ttaacaataa     2820

gtacattgat taatacattt aagtttataa gtaattattg aggatccagt attttcaaga     2880

ccttggccta gtttcttttc aattcaaaga tgagttgcaa aagacataat gttttgccta     2940

tggaagtaga tcatctagaa gaaaaagatt aaagaattag ttaagctttt tttttttttt     3000

ttttttgaga cagagtttca ctcttgttgc ccaggctgga attcagtggc tcgatcttgg     3060

ctcaccacaa cctctgcatt ctcctgcctc agcctcccga gtagctagga ttataggcac     3120

ctgccaccat gcccggctaa ttttgtttgt aattttagta gagatggggt ttctccatgt     3180

tggccaggct ggtttcgaac tcctgacctc aggtgatcta cccgcctcag cctcccaaag     3240

tgctgaaatt acaggcgtga gccacctcac ctggccatgt tctttatgga atactacaat     3300

gtgttgtcac aggatttgtt attcagatgt caatcatttt tatttatata tttctgggta     3360

aaacttatta gtggtgtgag gagtgcagaa tatggaagct tacctaaatt ctttttctgc     3420

cagccaacat tttaaaagac aaatgatgca tcctttctca atgctgctaa ttctttaaat     3480

tttacatgtc ccaatttatt ccatttgaga tttattttaa tgttttcaac ccctgtgtaa     3540

catgtatcat gaggagaaag cactatcatt gatcatcact atggattaaa atataggaat     3600

attttacagg gcagtatggg tgggggtggg agacatattg gaatcgtgtt ttctgggata     3660

aaatttttaa aaagaattaa tcattagccc tgagtatttt agtcatttgt gcctatagaa     3720

aacaacatgc tcttttattg tggactttct tcttttaagt gaggtttaat ttatatacaa     3780

tacaataaca gatttttaag tattcatttg agatgttttg acaactgtat atatacatgt     3840

aaccatcact ggaatcagat atagaatatt ccccttaaat attgtcaggt aaacacattg     3900

agaatatttt ttccagtctg tggcttacct acttattttc ataatgaatg ttttacttgt     3960

gatgaagatt taacttaccc ttttacttta atgattaata ttttctgtgt tctttctaat     4020

aaattttacg aactctgagg tta                                             4043


<210> 2361
<211> 2161
<212> DNA
<213> Homo sapiens

<400> 2361
gaagccacta gccggttact agctgcgctt ttgttccact tgagcgggca ctcttctgcg       60

gcaagcaggt ctaggaattc gcctggttcc cacctcgcgt cccttgcctt ccttcctagt      120

ctacccactg tagtgccccc tgcgtcccgc tccctcctag ccgactcaga gcacaagaag      180

gattgccacg gtttccattg cagcagccgt ggcgcctctg accctttttt tatatcgcgg      240

cgacggcggg ctgtcgtcac gacgacgtgc ggacgcagcg gcgggggcct ttcagcttat      300

gtggagaagt cgctgtgaag ccacctataa atccatttac tgaatttatg gagaaggctg      360

taaatgatgg aagtcattca gaagaactct tttgccatct taaaactata tcagagaaag      420

aagatttacc acggtgtacc agtgaaagtc atctcagctg gcgaatcttt ctgcattgaa      480

tttgaagatt tctgaacaga aggaaatatt aataaaagaa ttagacacct tcaaaagtgt      540

aaaactagct ttagaacatc ttcttagaaa gagagactac aaacaaacag gagacaattt      600

atccagcatg ttgctagaaa atctaactga taatgaaagt gaaaatacta atcttaagaa      660

gaaggtattt gaaaaggagg cccatatcca agaactttct tgtttgtttc agagtgaaaa      720

ggcaaatact ttgaaagcaa accgtttttc ccaatcagta aaagtagtac atgaacgact      780

acagatccaa attcataaaa gggaagccga gaacgataag ttgaaagaat atgtaaagag      840

cttagaaacc aagatagcca agtggaacct gcaatcaaga atgaataaga atgaggctat      900

agtgatgaaa gaagcaagta ggcaaaaaac tgtagcttta aaaaaggcat ctaaagttta      960

caaacaaagg cttgaccatt ttacaggagc tattgaaaag cttacttccc aaattagaga     1020

tcaggaagcc aagttgtctg aaacaatttc agcttccaat gcctggaaaa gtcattatga     1080

gaaaattgtg atagaaaaaa ccgaattgga agtacagatt gaaacaatga aaaagcaaat     1140

cattaatctt ttggaagatc tgaagaaaat ggaagaccat ggaaaaaatt catgtgaaga     1200

aattcttaga aaagttcact caattgaata tgaaaatgaa actctgaatc ttgagaatac     1260

aaaattaaag actacacttg ctgctttgaa ggatgaagtt gtatctgttg aaaatgaact     1320

ctcagaattg caagaagtag aaaaaaaaca gaaaaccctt attgaaatgt ataaaactca     1380

ggtacaaaag ttgcaagaag cagctgaaat agtaaaaagc agatgtgaaa atttgctaca     1440

taaaaataac caaataacaa aaaccaaaaa taaaaatgta gagaagatga gaggccagat     1500

ggagtctcat ctgaaggagt tagagcgtgt ctgcgattcc ttgacggcgg cggaacggag     1560

gcttcacgag tgtcaggaga gtctgcagtg ctgcaagggg aagtgtgcag accaggaaca     1620

caccattagg gagcttcagg gccaggttga tggaaatcac aatcttctga caaagctttc     1680

tctggaagag gaaaactgtc ttattcagct gaagtgtgaa aaccttcaac aaaaattaga     1740

acagatggac gcagaaaata aagagcttga gaagaagctg gcaaaccaag aagaatgtct     1800

taagcacagc aatcttaagt ttaaagagaa atctgcagag tatacagcat tggccagaca     1860

actggaagct gctttagaag aaggaagaca aaaggttgct gaagaaatag agaaaatgtc     1920

atctagagag agtgctttac aaattaaaat attagatctg gaaactgagc ttagaaagaa     1980

aaatgaagaa caaaatcaac ttgtttgcaa aatgaacagt aaagcacaac atcaggaagt     2040

gtgtttgaaa gaagtacaaa atagtcttga gaagtcggaa aatcaaaatg agagtattaa     2100

gaattattta cagtttctta aaacttctta tgtaacaatg tttgaataaa ttgtcaaatt     2160

t                                                                     2161


<210> 2362
<211> 1810
<212> DNA
<213> Homo sapiens

<400> 2362
ggagtatagg gcttgaactg agagcctggc ctcccagaag gttttaatag acctacggca       60

cagaaattga cacagcccgg aaaaggccca caaagagaag cccaaccagc cagcccccag      120

gccgccccgc cagggaccca ccaatgaggc acagatggca gccgctgccg ccctagcccg      180

gctggagcag aagcagtccc gggcctgggg ccccacatcg caggacacca tccgaaacca      240

ggtgagaaag gaacttcaag ccgaagccac cgtcagcggg agccccgagg ccccagggac      300

caacgtggta tctgagccca gagaggaagg ctctgcccac ctggctgtgc ctggcgtgta      360

cttcacctgt ccgctcactg gggccaccct gaggaaggac cagcgggacg cctgcatcaa      420

ggaggccatt ctcttgcact tctccaccga cccagtggcc gcctccatca tgaagatcta      480

cacgttcaac aaagaccagg accgggtgaa gctgggtgtg gacaccattg ccaagtacct      540

ggacaacatc cacctgcacc ccgaggagga gaagtaccgg aagatcaagc tgcagaacaa      600

ggtgtttcag gagcgcatta actgcctgga agggacccac gagttttttg aggccattgg      660

gttccagaag gtgttgcttc ccgcccagga tcaggaggac cccgaggagt tctacgtgct      720

gagcgagacc accttggccc agccccagag cctggagagg cacaaggaac agctgctggc      780

tgcggagccc gtgcgcgcca agctggacag gcagcgccgc gtcttccagc cctcgcccct      840

ggcctcgcag ttcgaactgc ctggggactt cttcaacctc acagcagagg agatcaagcg      900

ggagcagagg ctcaggtccg aggcggtgga gcggctgagc gtgctgcgga ccaaggccat      960

gcgggagaag gaggagcagc gggggctgcg caagtacaac tacacgctgc tgcgcgtgcg     1020

cctccccgat ggctgcctcc tgcagggcac tttctacgct cgggagcggc tgggggcggt     1080

gtacgggttc gtccgggagg ccctgcagag cgactggctg ccttttgagc tgctggcctc     1140

gggagggcag aagctgtccg aggacgagaa cctggccttg aacgagtgcg ggctggtgcc     1200

ctctgccctc ctgaccttct cgtgggacat ggctgtgctg gaggacatca aggccgcggg     1260

ggccgagccg gactccatcc tgaaacccga gctcctgtca gccatcgaga agctcttgtg     1320

aaataaaagc agggttggcc tcagccctgt gggtctgtct catgctctcc ctgttcctct     1380

ccccgccacc ccagggcctc caagccacct ctggaaatac ttggctctgc cccatgggca     1440

cgggaggggc gccagccgtg gagctgtgga attgggcccc gtggcagagc ccccatccct     1500

tgggggctgt ggggatgcgc ccaagccccc gagggagagg cctggggaca ccaacaaatc     1560

taagccctcc ctagctgctt ggtaactgtg tcatgaagct gccggacaga cacacgtggc     1620

atctccctgg gcaggagagc aggcctgcag catgggtcct gttcccgtgt gccgtgggtg     1680

gcagtggctg cacctggcac tagggctgct ctgtggatgt gggtgacaac ggcaggaggg     1740

gatgctggcc ttcctgcaca tagacctgca gttagtaaat cataagccca aataaacagg     1800

ttgtttgaat                                                            1810


<210> 2363
<211> 3256
<212> DNA
<213> Homo sapiens

<400> 2363
ggctccgcgt ccggcgcctg tttgtgctgc ggcgctgtgg caccggacgg ccctgccacc       60

ccacccccgg gagccgagag cggccccggg agagtccgag ggcccggggg ggtctggaga      120

ctgcggcccc gggcccacag cgccccctcc aggccccttc cccgcgcccg acagcgcccc      180

ctcggggtgg tggtacggcg cccttcgcgc gcgccccggg gtgcttcccc ttcccctctc      240

cccggccgtg gcccccgcgg cttagacgcc tcctccgccg ccgccgctcg gagcaacccg      300

ggggccggat ggacggggcc gcggggcccg gtgacggccc tgctcgggag gccctccagt      360

ctctgagcca gcggcttcgg gtgcaggagc aggagatgga actggtaaag gcagccctgg      420

cagaagccct tcgcctgctg cggctgcagg tgcccccttc ctccctgcag ggctctggca      480

caccagctcc tccgggggac agtcttgcag cccccccagg actgccaccc acgtgcaccc      540

cttccttggt gagccgaggc acccagacgg agacagaggt ggagctcaag tcatcccctg      600

gaccccctgg cctgagcaat ggacccccag cccctcaggg ggccagcgaa gagcctagcg      660

ggacccaatc tgaaggaggg ggcagcagca gcagtggtgc tggctcccct ggccccccgg      720

ggatcctcag gcccttgcag cccccacagc gtgctgacac gccgcgaaga aattcttcct      780

cctcctcatc cccctcagag cggcctcggc agaagctctc caggaaggca atctcctccg      840

ccaacctgtt agtgcggtcc gggagcacag agagccgtgg gggaaaagac cccctctcca      900

gccctggggg ccctggatct cggaggagca attacaattt ggaaggcatc tcagtgaaga      960

tgttccttcg agggcgcccc attaccatgt acatcccgtc tggcatccgc agccttgagg     1020

agctgccgag tggcccaccg ccagagaccc tcagccttga ctgggtttat gggtacaggg     1080

gtcgtgactc ccgctctaat ctgtttgtgt tgcgctctgg ggaggtggtc tactttatcg     1140

cctgtgtggt ggtgctgtac cggcctggag gaggcccagg gggtcctgga ggtggcggcc     1200

agagacatta ccgggggcac acagactgcg ttcgatgcct tgctgttcac cctgatggtg     1260

ttcgggtagc ctcgggacag acagctggag tggataagga tggaaagccc ctgcagcctg     1320

tggttcacat ctgggactca gagacgctgt tgaaactgca ggagattgga ctgggggcct     1380

tcgagcgggg tgttggggcc ctggcctttt cagctgcgga tcagggtgcc tttctttgtg     1440

tggtggatga ttccaatgag cacatgctgt cggtgtggga ctgcagccgg ggaatgaagc     1500

tggctgagat caagagtaca aatgactcag tcctggccgt tggcttcaac cctcgtgaca     1560

gcagctgcat cgtcaccagt gggaaatctc acgtccactt ctggaattgg agtggtggag     1620

taggggttcc tgggaatggg acccttaccc ggaaacaggg tgtctttggg aaatacaaga     1680

aacccaagtt tatcccttgc tttgtgttcc ttccggatgg agacattctc actggagact     1740

cagaggggaa cattctcacc tgggggcgga gcccttcaga ttccaagacc ccaggcaggg     1800

gtggcgccaa agagacctat gggattgtgg cccaggctca cgctcatgaa ggttctatct     1860

tcgccttgtg tctccggagg gacgggacag tgctgagtgg tggcgggcgg gaccgccggc     1920

tggtacagtg ggggcccggg ttggtggccc tccaggaggc tgagattccc gagcacttcg     1980

gggccgtgcg agccattgct gaagggcttg gctctgagct gctggtggga accacgaaga     2040

atgcattgct gaggggagac ctggcccagg gcttctcccc tgtaatccag ggccacactg     2100

atgagctctg ggggctctgc acacacccct cccagaaccg cttcctcacc tgcggccacg     2160

accggcagct ctgcctgtgg gatggggaga gccatgcact ggcctggagc atcgacctca     2220

aggagactgg tctctgtgct gacttccacc cgagtggggc agttgtggcc gtaggactga     2280

acacggggag gtggttggtt ttggacacag agaccagaga gatcgtgtct gatgtcattg     2340

atggcaatga gcagctctca gtggtccggt acagcccaga tgggttgtac ctggccattg     2400

gttcccatga caacgtgatc tacatctata gtgtttccag tgatggtgcc aaatccagcc     2460

gctttggccg ctgtatgggt cactccagct tcatcactca tcttgactgg tccaaggatg     2520

ggaatttcat catgtccaat tctggggact atgagattct ttactgggac gtggctggag     2580

gctgcaagca gctgaagaat cgctatgaga gccgagaccg ggaatgggct acctacacct     2640

gtgtgctggg ctttcacgtc tacggcgtct ggccggacgg ctccgatggg accgacatca     2700

actccctgtg ccgctcccac aacgagcgcg tggtggcggt ggccgacgac ttctgcaaag     2760

tgcatctctt ccagtacccg tgcgctcgtg ccaaggcgcc gagccgcatg tacgggggcc     2820

acggcagcca cgtgaccagc gtccgattca cgcacgacga ctcgcacctc gtctcgctgg     2880

gcggcaagga cgccagcatc ttccagtggc gagtgctggg cgctgggggc gcggggccgg     2940

cgcccgccac gccctctcga accccctccc tgtcccccgc ctcctccctc gacgtttgat     3000

cgctgcctgg cgggaccgac tggcccggcg gcgtggcccc gccccgccct gcccttccct     3060

ggcccaatcc cccacgacta ggggccgact ctttcctgga ctgacttcga gacattcccg     3120

atcgcgcatt ttcctggagg gcgcgaacgg cgcccctgca cacactgttt agacccgctg     3180

gctgagccgg gcagccccag cctaggcctt gactcccgct gcctgctgag gggcaataaa     3240

ccagaaccaa agtcgc                                                     3256


<210> 2364
<211> 4921
<212> DNA
<213> Homo sapiens

<400> 2364
gttgcctgcc tgtggtgtgt ggtgtggggg ggaggcctgg ggcagcagga gcaggacagc       60

cggacaggaa gcccagacgg ggttcgagca cctcaacttc tctcctgggg acactgttca      120

aactccgggg gccataggcc aagctgagcg atgggtgctg aggaggaggt gctggtcaca      180

ctatcagggg gagccccctg gggcttccga cttcatgggg gggccgagca gaggaaaccg      240

ttacaggtgt ctaagattcg aagacggagc caggctggca gagcaggact ccgagagagg      300

gaccagctct tggcaatcaa tggggtctct tgcaccaacc tctcccatgc cagtgccatg      360

agcctcatcg atgcctcagg aaatcagctt gtcctcactg tgcagcggtt agcagacgag      420

ggtcctgtgc aatctccatc tccccatgag cttcaggtgc tgtcaccctt atctccacta      480

agtcctgagc cccctggtgc tccagttcct cagcctcttc agcctgggag ccttcgttca      540

cctcctgata gtgaggctta ctacggagag actgacagtg atgctgatgg ccctgccacc      600

caggagaagc cccgtcgacc tcgccgccga ggccccacaa ggcccacccc tccgggtgcc      660

ccacctgatg aggtctacct gtctgacagc cctgcagagc cagcacctac tatccctggc      720

cctcccagcc agggtgacag ccgtgtgagc tccccgtctt gggaggatgg ggcagccctt      780

cagccacccc cagctgaggc tctgctgtta ccccatggcc ccctccgacc tggtcctcat      840

ctcatcccta tggtggggcc tgttccccac ccagtggcag aagatcttac taccacctac      900

acccagaagg ccaagcaagc caaactgcaa cgtgcagaga gcctccaaga gaagagcata      960

aaagaggcca agaccaaatg caggacaatt gcatccctgc tcactgcagc ccccaacccc     1020

cactccaaag gggtacttat gtttaagaaa cggcggcaga gagccaagaa gtacaccctg     1080

gtgagcttcg gggctgctgc tgggacaggc gctgaggagg aggacggcgt tccccccacg     1140

agtgagtccg agctggacga agaagccttc tctgacgccc gcagcctcac caatcaatct     1200

gactgggaca gtccctatct ggacatggag cttgccaggg cgggctcaag agcatcagag     1260

ggccagggct ctgggctggg agggcagctg agtgaggtct ctgggcgagg ggtgcagctc     1320

tttgaacagc agcgccagcg cgcagactcc agcacccagg aactggcacg ggtcgaacca     1380

gcagccatgc tcaacgggga aggcctgcag tcaccacctc gggcccagag tgctccccca     1440

gaggcagctg tgctcccacc cagccccttg ccggcgcctg tagccagccc cagacccttc     1500

caaccaggtg gtggagcccc gaccccagct ccaagcatct ttaaccggtc agccaggccc     1560

tttaccccgg gcctacaagg gcagcggcca actaccacct cggttatttt ccggccttta     1620

gcccccaaaa gggcgaacga cagcctgggg ggcctcagcc ccgccccacc ccccttcttg     1680

tcttcgcagg ggcccacccc tctgcccagc ttcacttcag gggttcccag ccacgcgcca     1740

gtctctggtt cccccagcac cccacgctcc tcgggccctg tgacagccac cagctccctg     1800

tacatcccag cccctagtcg gcctgtcacc ccaggtggag ctccagagcc ccccgctcct     1860

cctagcgcag ctgccatgac ctccaccgct tctatcttcc tatctgcgcc tttgcgaccc     1920

tctgcgcgcc cagaggcgcc tgccccaggc ccaggggctc ctgagccccc cagcgctcgc     1980

gagcagcgca tctctgtgcc agctgcccgc acgggtatcc tgcaggaggc ccggcgccgg     2040

gggacccgga agcagatgtt ccggccggga aaggaggaga cgaagaactc gcccaacccc     2100

gagctgctat cgctggtaca gaacctggat gaaaagcctc gggccggggg tgcagaatct     2160

ggtcctgaag aagatgctct gagcctcggg gctgaagcct gcaacttcat gcagccagta     2220

ggggccagga gttacaagac cctgcctcac gtgacaccta agaccccccc tccaatggct     2280

cccaagaccc cgccccctat gactcctaag actccacccc cagtggctcc taagccccca     2340

tctcgagggc tccttgatgg gctcgtgaat ggggcagcct cttcggctgg aatccctgag     2400

ccaccaaggc tgcagggcag gggtggggag ctgtttgcta agcggcagag ccgtgcggac     2460

aggtatgtgg tggaaggtac acctggtcct ggtcttggcc ctcggcctag aagtccttct     2520

cctaccccgt ctctgccccc ttcctggaaa tattcaccca acatccgtgc cccgcctcct     2580

attgcttaca acccactgct ctctcccttt ttcccccagg cggcccgaac tctccctaag     2640

gcccaatccc aggggcctcg ggcaacaccc aagcagggca tcaaggctct agattttatg     2700

cggcatcagc cctatcaact taaaactgcc atgttctgtt ttgatgaggt tcccccgact     2760

cctggcccta tcgcctcagg gtcccccaaa actgcccgag tccaggagat tcgccggttt     2820

tccactccgg caccccagcc cactgcagaa cccctggctc ccactgtgct tgccccccga     2880

gcagccacta cactggatga gcccatctgg agaacagaac tggcctcagc ccctgttcct     2940

agcccagccc ctcctccaga ggctcccagg ggccttgggg cttctcccag ctcctgcggt     3000

ttccaggtag ccaggccccg attttcagcc accagaacag gattgcaagc tcatgtgtgg     3060

aggcctgggg cagggcacca gtgaacaggc acaggtccca ggaccaagga gaggtggaac     3120

atccagttcc taaagttgct tctcctaccc tatcccatcc cctgtcacgc atctggaagc     3180

taaattgcct cctgccagag atggtttcca agttgatgtc cccttccccc accttcctcc     3240

tcactctcta cctccctgcc gctttccaac caagtatgtc tgctttggta tctttgcctc     3300

tctttgtctc tgcatttcct ttcctggatc tctgtcttta tttccaggct tctccaccca     3360

tattcctcca cagatctctc ttccttgaca tttgtgcttt tctccctggg cctcatttta     3420

atgttcagtg agaagtaaac agagcagaag tgaccactgg gacttcaggc aagaagctca     3480

ccaccaggca cacagcaaag ggactgaact gacccctgtt tgcactaagc cacccccacc     3540

ccccactctg ctttcccaag cttgactggc atatacctag gcctgtgtgt gtgtgtgtgt     3600

gtgtgtgtgt gtgtgtgtgt gtgctcttcc gtctaaggca tgaataagag gggaggtcaa     3660

aataaagacc caatctgagg ccgggcacgg tggctcacgc cggtaatccc agcactttgg     3720

gaggccgagg cgggcggatc acgaggtcag gagatcgaga ccatcctggc taacacggtg     3780

aaaccccatt tccactaaaa atacaaaaaa ttagctgggc gtggtggcga gcgcctgtag     3840

tcccagctac tcgggaggct gaggcaggag aatggcatga acctggaagg cggagcttgc     3900

agtgagctga gattgcgcca ctgcactcca gcctgggcga cggagcgaga ctctgtctca     3960

aaacaaacaa acaaacaaaa gacccaatct gagtcttatc gttgtactga tagaagggtc     4020

agatatcccc acatggagtt gagtgggaga aagagattca ctagagaata actccttaga     4080

gaccaatgtc tgtagcaggt gtacagcatc ttgtgaaagt tatggagcat gaaaagactg     4140

aagggccagg acagtttgca tgggctgagt tataccagct agaccaggaa tagaacaaag     4200

aattctatac ctcaggattt caaaaagtta gcaacttgag aggccagtgc tgagcaaccc     4260

agtacccagg aaatgaaaaa aagaaagaaa attccctccg agaatgaaca aatcattggc     4320

ttcattgcct catgagcttg agagaaagga gaagagagcc agagtgtggc aagtgaggcc     4380

aaaatcagaa gcatggcaga aatgagtgta agtgattgag ccacagacag aagtgtggcg     4440

agggacaatg ccatattggg agaaggtaaa gttgagtaac aagaaaccaa ccgtgtgtga     4500

gagggggatt ggaaaaaaat ttgagggaga agaatgttag aatggaaggg aatgatggtg     4560

gaagggaggt gtgagggtgt gtgctgagtg ttgaaagaac ggttggtgtc tgtgtgattt     4620

tccttgagtc tgttcttcag tgtgtcttct gcagcttgcc atgactgcct gggaaagagt     4680

agggaaatac ccagagccaa aacctccttt cagtcccacc ccatccctca aaaccccagc     4740

tattgcttct tttcagcttc aggtcctgat ctccaatctt agtatggact cccttctcac     4800

caagaccacc accagctacg tttgctgtgt aatctggaaa gtgataattt cctttgcttg     4860

ttgggtgtga gtcacaatac tttggtttgt gcacaagaat aaatttatgc cccatacctt     4920

c                                                                     4921


<210> 2365
<211> 3964
<212> DNA
<213> Homo sapiens

<400> 2365
cttgccgagg attggctgag ccttcagttt tgaaaatcat agttttcgcc cgcgctgcgc       60

cgcctggttg ctcctcccgt gcggtgagtc ccgaaggccc ggagccaagt gggtctgggc      120

aagcggggcc ttacctaggg ataccaccgg acttggatcg gagcagcctt caggggacgt      180

ggcgcagtcg aacagagcca ccatggggac gacggcccca gggcccattc acctgctgga      240

gctatgtgac cagaagctca tggagtttct ctgcaacatg gataataagg acttggtgtg      300

gcttgaggaa atccaagagg aggccgagcg catgttcacc agagaattca gcaaagagcc      360

agagctgatg cccaaaacac cttctcagaa gaaccgacgg aagaagagac ggatttctta      420

tgttcaggat gaaaacagag atcccatcag gagaaggtta tcccgcagaa agtctcggag      480

cagccagctg agctcccgac gcctccgcag caaggacagt gtagagaagc tggctacagt      540

ggtcggggag aacggctccg tcctgcggcg tgtgacccgt gctgcggctg cagctgccgc      600

ggctaccatg gcattggctg caccttcttc acccacccct gagtctccca cgatgctgac      660

taagaagccc gaggataacc acacccagtg ccagctggtg cctgtggtgg agatcggcat      720

cagtgagcgc cagaatgctg agcagcatgt cacccagctc atgtccaccg agcctctgcc      780

ccgcactctg tccccgactc cagcttcagc cacagctcca acctcccagg gcatcccgac      840

atcagatgag gaatcaacac ctaagaagtc gaaggccagg atactggagt ccatcacagt      900

gagctccctg atggctacac cccaggaccc caagggtcaa ggggtcggga cggggcggtc      960

tgcgtctaag ctcaggattg cgcaggtctc ccctggccca cgggactcgc cagcctttcc     1020

agattctcca tggcgggagc gggtgctggc tcccatcctg ccggataact tctccacgcc     1080

cacgggctct cgcacggact ctcaatcggt gcggcacagc ccgatcgccc cgtcttcccc     1140

gagtccccaa gtcttagccc agaagtactc tctggtggcc aaacaggaaa gtgttgtccg     1200

cagggcgagc agaaggcttg ccaagaagac tgccgaagag ccagctgcct ctggccgcat     1260

catctgtcac agttacctgg agaggctcct gaatgttgag gtgccccaga aagttggttc     1320

tgagcagaag gaaccccccg aggaggctga gcctgtggcg gcagctgagc cagaggtccc     1380

tgagaacaat ggaaataact cgtggcccca caatgacacg gagattgcca acagcacacc     1440

caacccgaag cctgcagcca gcagcccgga aacaccctct gcagggcagc aagaggccaa     1500

gacggaccaa gcagatggac ccagagagcc accgcagagt gccaggagga agcgcagcta     1560

caagcaggcc gtgagtgagc tggacgagga gcagcacctg gaggatgagg agctgcagcc     1620

ccccaggagc aagacccctt cctcaccctg cccagccagc aaggtggtac ggcccctccg     1680

gacctttctg cacacagtgc agaggaacca gatgctcatg accccgacct cagccccacg     1740

cagcgtcatg aagtccttta ttaagcgcaa cactcccctg cgcatggacc ccaagtgcag     1800

cttcgtcgag aaggagcggc agcgcctgga gaatctgcgg cggaaggagg aggccgagca     1860

gctgcgcagg cagaaggtgg aggaggacaa gcggcggcgg ctggaggagg tgaagctgaa     1920

gcgtgaggaa cgcctccgca aggtgctgca ggcccgcgag cgggtggagc agatgaagga     1980

ggagaagaag aagcagattg agcagaagtt tgctcagatc gacgagaaga ctgagaaggc     2040

caaggaggag cggctggcag aggagaaggc caagaaaaag gcggcggcca agaagatgga     2100

ggaggtggaa gcacgcagga agcaggaaga ggaggcacgt aggctcaggt ggctgcagca     2160

ggaggaggaa gagcggcggc accaagagct gctgcagaag aagaaggaag aggagcagga     2220

gcggctgcgg aaggcggccg aggctaagcg gctggcagag cagcgggagc aggagcggcg     2280

ggagcaggag cggcgcgagc aggagcggcg cgagcaggag cggcgggagc aggagcggcg     2340

cgagcaggag cgacagctgg cagagcagga gcgtcggcgg gagcaggagc ggctccaggc     2400

cgagagggag ctgcaggagc gggagaaggc cctgcggctg cagaaggagc agctgcagag     2460

ggaactggag gagaagaaga agaaggaaga gcagcagcgt ctggctgagc ggcagctgca     2520

ggaggagcaa gagaagaaag ccaaggaggc agcaggggcc agcaaggccc tgaatgtgac     2580

tgtggacgtg cagtctccag cttgtacctc atatcagatg actccgcaag ggcacagggc     2640

ccctcccaag atcaacccag ataactacgg gatggatctg aatagcgacg actccaccga     2700

tgatgaggcc catccccgga agcccatccc cacctgggcc cgaggcaccc cgctcagcca     2760

ggctatcatt caccagtact accacccacc gaaccttctg gagctctttg gaaccattct     2820

cccactggac ttggaggata tcttcaagaa gagcaagccc cgctatcaca agcgcaccag     2880

ctctgctgtc tggaactcac cgcccctgca gggcgccagg gtccccagca gcctggccta     2940

cagcctgaag aagcactgag gctggcctgc ggccttcttg gcagcctcgc ctcctgtcca     3000

tgtctatctg tctgtctgtc ggtctctgtc ttggtctgtt gccctccttc ttggcatgcc     3060

attgtggagg gcttggccag gtgtatataa acgtcctctg tgctgggtgt ttctgctgca     3120

ggtggcaggt ggccccaggc ctgtttggag gatgggctgg gtgggtgggt ggggaagaaa     3180

tgggcccagc cccacatggc ctgcagacag tgctctgtaa atagttgttt taatttagct     3240

gaatgttagc attttagtct ttggcatttt agcgtttggg aggtagatta ataaagtata     3300

ttccttcaag cctgctgttg ataccatgaa gactgggcgc ctcagtccca gccctgtagc     3360

tgtgtgtctt gggccaccag tggcctgcag gacgaaggta ctgttccatc acctgcggtg     3420

tgcctcagga tcaccaggtg caggccccca ccctcggaga tgctgctgca gtgagtggtt     3480

ccactgcctg gataaccctt gaggaacacg tcagttactg tcacgatggg gcaggtggag     3540

ctccttccta ttttttgggg tgctccctgt ttgtaaaggg gagtttgttc attgggaaag     3600

acctgggtct tgacacggcc ctgccactta gtcccctacc ctctccattc cccaggctcc     3660

acccgtgctg ctcaggtgca aatggacttg agagcatcta tgtgctggtg aagcatgagg     3720

tctgagtaga aaaggggtat cccttgagac caccttggga ccagtgcttg caagcagcga     3780

gatatttccc cagcaaaacc aggcagctgc taattaaatg cttagaacca atgaaagctg     3840

gctgtggtcc tgcctgtgag ctgcctactg ctgccttctg aatgcatata tctgctactg     3900

tagccccggg ttgtcaaact atggcctgtg ggccaaatcc agccacagtc ggttctttaa     3960

agtt                                                                  3964


<210> 2366
<211> 4696
<212> DNA
<213> Homo sapiens

<400> 2366
accgcctcgc ctctttccgc cagcgcccgc aggacccgga tgagagcgca cgcttcgggg       60

tctccgggaa gtcgcggcgc cttcggatgt ggcggatgcg gccgtgagcc ggcgggggag      120

gtgctgctgc tgcctccact gtactcagac ccaggtagca caggattgtc catcctccag      180

cagctcagtg caacggtgtg aactcagcct gtttcagagc ctccacacca tgacctccaa      240

gaagctggtg aactcggtgg ctggctgtgc tgatgacgct cttgctggcc tggtggcctg      300

caaccccaac ctgcagctcc tgcagggcca ccgcgtggcc ctccgttctg acctggacag      360

cctcaagggc cgggtggcac tgctgtcggg tgggggctct ggccatgagc ctgcccatgc      420

tggtttcata gggaagggga tgctgactgg ggtcatcgcg ggagctgtgt tcacctcccc      480

ggcagtgggc agcatcctgg cagccatcag ggccgtggcc caggccggca cagtggggac      540

gctccttatc gtgaagaact acactgggga tcggctcaac ttcggcctgg cccgggagca      600

ggcccgggct gaaggcatcc cggtggagat ggtggtgatt ggggacgaca gcgccttcac      660

tgtcctgaag aaggcaggcc ggcgggggct gtgcggcacg gtgcttatac acaaggtggc      720

aggtgctctg gctgaggctg gtgtggggct ggaggagatc gcaaagcagg tgaacgtggt      780

cgccaaggcc atgggtaccc tgggggtgag cttatcctcc tgcagcgtcc ctggttccaa      840

acccaccttc gagctctcag ccgacgaggt ggagctgggc ctggggatcc acggggaagc      900

tggtgtgcgc cggataaaga tggcaaccgc cgatgagatt gtgaaactca tgctcgacca      960

catgacaaac accaccaacg cgtcccatgt gcctgtgcag cccggctcct cagttgtgat     1020

gatggtcaac aacctgggtg gcctgtcatt cctggaactg ggcatcatag ccgacgctac     1080

cgtccgctcc ctggagggcc gcggggtgaa gattgcccgt gccctggtgg gcaccttcat     1140

gtcagcactg gagatgcctg gcatttctct caccctcctg ctggtggatg agcctctcct     1200

gaaactgata gatgctgaaa ccactgcagc agcctggcct aacgtggctg cagtctccat     1260

tactgggcgg aagcggagcc gggtagcccc tgccgagccc caggaggccc ctgattccac     1320

tgctgcagga ggctcagcct cgaagcggat ggcgctggtg ctggaacggg tgtgcagcac     1380

tctcctgggc ctggaggaac acctgaatgc cctggaccgg gctgctggtg acggcgactg     1440

tggcaccacc cacagccgtg cggccagagc aatccaggag tggctgaagg agggcccacc     1500

ccctgccagc cctgcccagc tgctctccaa gttgtctgtc ctgctcctgg agaagatggg     1560

aggctcatct ggggcgctct atggcctgtt cctgactgcg gctgcacagc ccctgaaggc     1620

caagaccagc ctcccagcct ggtctgctgc catggatgcc ggcctggaag ccatgcagaa     1680

gtatggcaag gctgctccag gggacaggac tatgctggat tctctgtggg cagcggggca     1740

ggagctccaa gcctggaaga gcccaggagc tgatctgtta caagtcctga ccaaagcagt     1800

caagagtgcc gaagctgcag ccgaggccac caagaatatg gaagctggag ccggaagagc     1860

cagttatatc agctcagcac ggctggagca gccagacccc ggggcggtgg cagctgctgc     1920

catcctccgg gccatcttgg aggtcttgca gagctagggt gtgtgactgc ctcccttggc     1980

ctcagctcct ctcactgctg tgctgaggtg gcctttgtca cttccttctg ccttccaacc     2040

ctcaccttcc cccggcctgg ccccattggc ccaccctcta agttgagcag gaaatcctcc     2100

accaagcttc cagaactaca gacagcaccc agagtgagct ggagtgggtc cccatgcctc     2160

tccagcatgc cctttccctt tgcaggaggg tggagtccct gggtcatgcc ctcccctgcc     2220

agctctgggc ttcagagata aggcattttc cttgtgcagc ctttacctgg caatcctaat     2280

ttggttttaa gactccctgt gaaatgcttt ccgcacctta accccagtga gcgtgaaaaa     2340

gaaagttaat aaactataat acatggaagc aagaaagaca ctgcctcctc tgagggacct     2400

tttcccaagc atgtaaacaa gggggcccac agccctggct gcaggcatca tgacccatct     2460

tctaccaggc agatctttat tacctgagcc cctaaggcag tgtctcctca gctgggctgc     2520

ttccactgag acccccgacc catccccttt ccagtacaca cacctgatgc atgtaagaat     2580

ggtagagggg cttttcttag cattgaatta ataattcagt ggctcctcgg gagtcgaatg     2640

ggcatttggg acaccagaag gaaaagaaat catcatagtc taaggttcag ttgtagatca     2700

aaaaatgcag ccaggccggg cacggtggct cacacctgca atcccagcac tttgggaggc     2760

caaggcaggc ggatccctta cactcaggag ttcaagacca gtctgggcaa catggtaaaa     2820

ccctgtctct accaaaaaat acaaaattag ccaggcatag tagtgtgtgc ctatagtcct     2880

aacttgggag gctgagttgg gaggatggct tgggcccagg aggtcgaggc tgcggtgagc     2940

cataagcatg ccactatact ccagcctggg caacaaagcg agaccctgtc tcaaaaaaaa     3000

aaaaaaaaaa aaaagaaact gcagccaagc cagcccctag gtctctttct agagcgatca     3060

ctgatggcac cagggtgagc aggggcactg tatgcatgtg gagacaaaca gcacatgcct     3120

ggcacacatg tagggtaggg agtggttaaa ggcactggct gtcgactcat acacatgatc     3180

tgaaatctga ttctgcttta acccggctac aggagctaag gcctattttt tagccctttg     3240

ggatctgtaa aatcagaatg gtacccacct catggggaca tgaaaggatt caaatgaatt     3300

gatgaagatg ggccataaag cccagcacag tccaagtgct cactcactga gagttacggt     3360

tatcacaggg gttgggcccc cagcccctcc caggtcatct gctctaccac tagctggtag     3420

gaaagagcct cctgccctcc caacccccgt cacctacttg gcccaaattt ggctgcaggc     3480

tccccgagtg cctgggcttc tctacccagg gtcctgtctg tcggctgcac catacgtccc     3540

tgaccacaag gcatccacgt gcacaggagt atgcgcccag cagctgggaa ggaggctgac     3600

ctcagacggt ggcctgtgga tcccagctct gtcatttcct ggctgggtga cctcaaccta     3660

gtcacccttt ttgagtcttg ttttctcaga ttatgaaata ggaaaaattt ccttcctcgt     3720

gagataagca cgtgccatta gctattaagg acacgcacat aaatgagctg catgtgaatc     3780

cacacatgcc attccatgaa gacagaggat catgtggatc tttggtgcct tccggttggc     3840

ccctccctag gtctgtgagg gtcagacctg tcctgaggct tttacaaatt ggcccagaac     3900

tcatttaacc acagcatcat ttcattagag ggctgttatt agagactgaa tgtttgtgtc     3960

ccccccaaat tcctgtgttg aaaggctcac ccccactatg gtagtgttag gacgtggggc     4020

ctttgggagg tgatggggtt atgagggtgg agccccagag agctctcacg ccctttccac     4080

catgtgaggt tatggtgaga agatggtctc tgaggaagct ggcccttgcc acacaccaca     4140

tttgccagcg ccttcatctt ggatgtctat agcctccaga actgtgagaa ataaacactt     4200

gttgtttaag ccacccaggc tattatattt ttgttatagc agcctgaaca aagacagctt     4260

tgattcttaa catatttaat gaaactcgag cttcataaac cagtgaaatg cctaccccta     4320

tggagatggg gagctggtca tgggacccag gtgcctggag gacatcccag tggctttgaa     4380

ggctccagcc agtcaagacg gtcaatatta gcccttctgc caacatctgg caatgtgagg     4440

ctggggtgga cgttggcctg atgttgccag gagtaggatg ctgatgctgc cagagagtag     4500

gtgggctcca aaccccaggc ttctcacttg cttactaagc acagcagtct gaagcttggg     4560

acctggcagt gcgtctttgg agaaggcaaa aaagccacag cagcaacact taggagcaag     4620

acccttcccg ctctccaccc tatttcctcc cctgaagaag agcaacagct caagctctag     4680

catggcacag aacgct                                                     4696


<210> 2367
<211> 1999
<212> DNA
<213> Homo sapiens

<400> 2367
gggctggtgg ggtgaaccct tcatcctggg tcttttaatt tctcaggcgg aacgagtggc       60

ggcggacaga ggcttttggc tgcgctgtct gtgggttgtc tgggcttggg gaactgggca      120

cggagaccgt ggcgccggcc gccggtcata cagctctgct tccagtcgtc gggcaaaaag      180

ctgaggcgct tctcctttaa ttgcggtggg cggggcgtgc cgacgcggcc cgcgttgcta      240

ttggtggccg ttgggggcgc ggaaactgaa cgggccgcaa cggccaccgc agctgccttc      300

ggcgccgcca gccccgccat ggctgcgccc tgcgcggagg acccctcgct ggaaaggcat      360

tttaagggcc accgagatgc agttacctgt gtggacttca gtatcaacac aaagcagctg      420

gccagtggct ccatggactc atgcctcatg gtctggcaca tgaagccgca gtcacgcgcc      480

taccgcttca ctggccacaa ggatgccgtc acctgtgtga acttctctcc ttcgggacac      540

ctgcttgctt ccggctcccg agacaagact gtccgcatct gggtacccaa tgtcaaaggt      600

gagtccactg tgtttcgtgc acacacagcc acagtgagga gtgtccactt ctgcagtgat      660

ggccagtcct tcgtgacagc ctctgacgac aagacagtca aagtgtgggc aactcatcgc      720

cagaaattcc tgttctccct gagccagcat atcaactggg tccgctgtgc caagttctcc      780

cccgacgggc ggctcatcgt gtctgccagt gatgacaaga ctgttaagct gtgggacaag      840

agcagccggg aatgtgtcca ctcgtattgt gagcatggcg gctttgtcac ctatgtggac      900

ttccacccca gtgggacgtg cattgccgct gccggcatgg acaacacagt gaaggtgtgg      960

gacgtgcgga ctcaccggct gctgcagcat tatcagttgc acagtgcagc agtgaacggg     1020

ctctctttcc acccgtcggg aaactacctg atcacagcct ccagtgactc aaccctgaag     1080

atcctggacc tgatggaggg ccggctgctc tacacactcc acgggcatca gggaccagcc     1140

accactgttg ccttttcaag aacgggggag tattttgctt ctggaggctc tgatgaacaa     1200

gtgatggttt ggaagagtaa ctttgatatt gttgatcatg gagaagtcac gaaagtgccg     1260

aggcccccag ccacactggc cagctccatg gggaatctga cagtctccat tctggagcag     1320

cggttgacac tgacagaaga caagctgaag cagtgtctgg agaaccagca gctaatcatg     1380

cagagagcaa caccatgatc aggggagcag gaatcaggag ctcggtggat ttgcaggtgg     1440

caggccaggg atttgtacca tgggacttgg gtaaataaag gggactgaac tctgtgggaa     1500

tcacatccat actggagccc tggatttttg cagttctgcc ctccaccttg ctatctgcac     1560

caggaggctc tccacctggc agccagaggt ccccagtggg ccgggctcac acacaaatga     1620

tgcttcagac ccgaatgaga ggaccacatt ttgcttaatg taaaggagcc acttgaaaat     1680

gtctgctcct tcggggtcct gagattgtgg ctccccctct ggaggaggtg gctccacgat     1740

gccttgattt tcactcatca tttggacatg tgactggctt ttcctacctc tgccatggtg     1800

tagaaattga ttgcacattg attggatgag ccgggggttt tctctaaatc tgactaaagg     1860

cccaaagtgg gcccatctga gtcaggtttg ttgagaacaa gccctctcaa gtgggtggtg     1920

gcttttcagt ggccctgatt tctgttccac acgtgttcac tggagccagg tgacttcctc     1980

cttgcgtgag tgagggcac                                                  1999


<210> 2368
<211> 1818
<212> DNA
<213> Homo sapiens

<400> 2368
ctccggcccc aggtcaccgc cagcacgcgc ctgcttcccg tctgcgcgag tccacgcagc       60

tccccagatc aagaagctga ggccccaggt tacacactaa agtaaatggc agaggcagaa      120

ataacaccta tgtcctcctg accccaaggc atgttcttaa agttctggaa acctcctgga      180

ggcttccttg ctgctcctct gggactgcca ccctgggcag ggtgttctgt ggcccctcat      240

catcgtggtt ttgaaccaca ggcccttcac cagcacagca gcagcaggca tggcagcaag      300

cgtggagcag cgcgagggca ccatccaggt gcagggccag gccctcttct tccgagaggc      360

cctgcccggc agtgggcagg ctcgcttctc tgtactgctg ctgcatggta ttcgcttctc      420

ctccgagacc tggcagaacc tgggtacact gcacaggctg gcccaggctg gctaccgggc      480

tgtggccatt gacctgccag gtctggggca ctccaaggaa gcagcagccc ctgcccctat      540

tggggagctg gcccctggca gcttcctggc ggctgtggtg gatgccttgg agctgggccc      600

cccggttgtg atcagtccat cactgagtgg catgtactcc ctgcccttcc tcacggcccc      660

tggctcccag ctcccgggct ttgtgccagt ggcccccatc tgcactgaca aaatcaatgc      720

tgccaactat gccagtgtga agactccagc tctgattgta tatggagacc aggaccccat      780

gggtcagacc agctttgagc acctgaagca gctgcccaac caccgggtgc tgatcatgaa      840

gggggcgggg cacccctgtt acctggacaa accagaggag tggcatacag ggctgctgga      900

cttcctgcag gggctccagt gaagcccagc actgctgcag ggggtgggct gcctgcctgc      960

tctgagctct ctcttgcacg ctctctcttc tctcccaggc tctggctcat gcacatgcaa     1020

caggtgcgtc tgtctatatg tctgggttct tgtcttttgt ggtctgtttg tcttttctac     1080

ctctttctct tgcagtgata gactgagggg gtaaaatcaa gagaaaaaac tctcaggaat     1140

caaggaacat aatcctgtgg agggtaatcc attacatgag cttctcctgt tcttccactt     1200

tcctgcctgg ctttcactcc ttcccctgct ctgcccagcc tttccctccc acccactcct     1260

ccttctgcaa atgccctgaa ggccagccct taccccaaca cccacttccc cacctcctta     1320

ggccccagat acatacatgc ccacatgcac gcttacatgt ttagagccat ccttgtttcc     1380

aaatatgacc cttcgcttga gggcaactgc ataggtacat ctaactctgg actggcatgc     1440

acattgtcat gtgcagcttt gcatatacac acatgcatac atgagcctcc acacaagcac     1500

ttgcacacat gtggactcct aaccatgcta acctcactgg ctgggaaggt ggggacccca     1560

tgggccagcc cttgcaggag gcccttttgc aaggcttagg gtgtggccag ccctgaaagc     1620

tacttggaca caggtttcag ctggccccag cccagaagtg acccccagaa agggagggcc     1680

accgctttgc cccctgcttt tacccttcct tctgggtgct ctacacctca ggttaccagg     1740

cctgaggcat ctcagccaag cttgtttcct gctctgaggc ttgtggggtg ggagccagag     1800

tggaggtcgg tgaaataa                                                   1818


<210> 2369
<211> 3446
<212> DNA
<213> Homo sapiens

<400> 2369
gctaaccttg ccgcgggccg agccctgcct cgccatggac caggactatg agcggcgcct       60

gcttcgccag atcgtcatcc agaatgagaa cacgatgcca cgcgtcacag agatgcggcg      120

gaccctgacg cctgccagct ccccagtgtc ctcgcccagc aagcacggag accgcttcat      180

cccctccaga gccggagcca actggagcgt gaacttccac aggattaacg agaatgagaa      240

gtctcccagt cagaaccgga aagccaagga cgccacctca gacaacggca aagacggcct      300

ggcctactct gccctgctca agaatgagct gctgggtgcc ggcatcgaga aggtgcagga      360

cccgcagact gaggaccgca ggctgcagcc ctccacgcct gagaagaagg gtctgttcac      420

gtattccctt agcaccaagc gctccagccc cgatgacggc aacgatgtgt ctccctactc      480

cctgtctccc gtcagcaaca agagccagaa gctgctccgg tccccccgga aacccacccg      540

caagatctcc aagatcccct tcaaggtgct ggacgcgccc gagctgcagg acgacttcta      600

cctcaatctg gtggactggt cgtccctcaa tgtgctcagc gtggggctag gcacctgcgt      660

gtacctgtgg agtgcctgta ccagccaggt gacgcggctc tgtgacctct cagtggaagg      720

ggactcagtg acctccgtgg gctggtctga gcgggggaac ctggtggcgg tgggcacaca      780

caagggcttc gtgcagatct gggacgcagc cgcagggaag aagctgtcca tgttggaggg      840

ccacacggca cgcgtcgggg cgctggcctg gaatgctgag cagctgtcgt ccgggagccg      900

cgaccgcatg atcctgcaga gggacatccg caccccgcca ctgcagtcgg agcggcggct      960

gcagggccac cggcaggagg tgtgcgggct caagtggtcc acagaccacc agctcctcgc     1020

ctcggggggc aacgacaaca agctgctggt ctggaatcac tcgagcctga gccccgtgca     1080

gcagtacacg gagcacctgg cggccgtgaa ggccatcgcc tggtccccac atcagcacgg     1140

gctgctggcc tcggggggcg gcacagctga ccgctgtatc cgcttctgga acacgctgac     1200

aggacaacca ctgcagtgta tcgacacggg ctcccaagtg tgcaatctgg cctggtccaa     1260

gcacgccaac gagctggtga gcacgcacgg ctactcacag aaccagatcc ttgtctggaa     1320

gtacccctcc ctgacccagg tggccaagct gaccgggcac tcctaccgcg tgctgtacct     1380

ggcaatgtcc cctgatgggg aggccatcgt cactggtgct ggagacgaga ccctgaggtt     1440

ctggaacgtc tttagcaaaa cccgttcgac aaaggtaaag tgggagtctg tgtctgtgct     1500

caacctcttc accaggatcc ggtaaacctg ccgggcagga ccgtgccaca ccagctgtcc     1560

agagtcggag gaccccagct cctcagcttg catggactct gccttcccag cgcttgtccc     1620

ccgaggaagg cggctgggcg ggcggggagc tgggcctgga ggatcctgga gtctcattaa     1680

atgcctgatt gtgaaccatg tccaccagta tctggggtgg gcacgtggtc ggggaccctc     1740

agcagcaggg gctctgtctc ccttcccaaa gggcgagaac cacattggac ggtcccggct     1800

cagaccgtct gtactcagag cgacggatgc cccctgggac cctcactgcc tccgtctgtt     1860

catcacctgc ccaccggagc cgcatgctct tcctggaact gcccacgtct gcacagaaca     1920

gaccaccaga cgccagggct gattggtggg ggcctgagac cccggttgcc cattcatggc     1980

tgcaccccac catgtcaaac ccaagaccag ccccaaggcc agaccaaggc atgtaggcct     2040

gggcaggtgg ctcggggcca ctggcggagc cagcctgtgg atccaagaga cagtccccac     2100

ctgggcttca cggcatcctt gcagccacct ctgctgtcac tgctcgaagc agcagtctct     2160

ctggaagcat ctgtgtcatg gccatcgccc ggcggtcagt gggcttcaga tgggcctgtg     2220

catcctggcc aagcgtcacc ctcacactgg aggaggatgt ctgctctgga cttatcaccc     2280

caggagaact gaacccggac ctgctcactg ccctggctgg agaggagcac aacagatgcc     2340

acgtcttcgt gcattcgcca acacgtgccc tcacagggcc agcgtcctcc ttccctgcgc     2400

aagacttgcg tcccccatgc ctgctgggtg gctgggtcct gtggaggcca gcagcggtgt     2460

ggcccccgcc cccaggctgc ctgtgtcttc acctgtcctg tccaccagcg ccaacagccg     2520

tggggaagcc aaggagaccc aaggggtcca ggaggtgggc gccctccatc cttcgagaag     2580

cttcccaggc tcctctgctt ctctgtctca tgctcccagg ctgcacagca ggcagggagg     2640

gaggcaaggc aggggagtgg ggcctgagct gagcactgcc ccctcacccc cccaccaccc     2700

cttcccattt catcggtggg gacgtggaga gggtggggcg ggctggggtt ggagggtccc     2760

acccaccacc ctgctgtgct tgggaacccc cactccccac tccccacatc ccaacatcct     2820

ggtgtctgtc cccagtgggg ttggcgtgca tgtgtacata tgtatttgtg acttttcttt     2880

ggatttgttt tgtgtttttg ttgactagtc ctggaaatgt ttgaggctag acggggaggg     2940

gccaggaccc acccactgct cctgggggat gaggtcctgg ttttaaagcc ccgtcatttc     3000

aagcgggtcg atcttccaca ttcactggag agactctccc cacctctgtc tgggtggggc     3060

gcggacccct cactgtgcgc ctgtgcaggg ggtgctggtg cacgtggcag tgtggatttc     3120

cagtggtcac ggtcttactg tttcaaggtt tttaaataag aaaaccaacc ctgccttcgc     3180

ccatgcccgc ccctgcccgc agttgccaaa gagccgcctt gtcgctgtgg gcgtcagggc     3240

ttggctggct cagtgcacaa cccacagtgg ccttcagagg ctcctcctgg gactgggaac     3300

cgccgcaggg ccaggcggac ggcgtgaggt ttgtgttggg gctggttctg cccatgctag     3360

ggggtggggg agctcccagg acagaccagc cttgtttctc atgtaatgca gtgacgctgt     3420

cattaaacac gtggattcat gtgtgg                                          3446


<210> 2370
<211> 884
<212> DNA
<213> Homo sapiens

<400> 2370
atcttgagtg agggcacgct ctccttagag gggcggaaca gtttttggca ccttatcgcg       60

agcggcagct tatgcaagag tgatttaaaa aagaaaggca ggtccggagc caggggctaa      120

gtagcggtgc ggtttctttt tctggattag tttccccatc ttgcctaaaa atgtcctagt      180

ctagtctttt tagcagaact ccactcccta aacatgtcag aactacactt cccatcaagg      240

gtcagaaaga aacttccggc acagtctttt cccagcattc cttgtttact tccgggttta      300

ttactactga aggaagaacg ccagatcaga aaagggagct caggtacctt ccagagagtg      360

agacccagcg cccttgtctc gcacccagta ggctttcatc cccgccatgg cggagctgat      420

ccagaagaag ctacagggag aagtggagaa atatcaacag ctacagaagg acttaagtaa      480

atccatgtcg gggaggcaga aacttgaagc acaactaaca gaaaataata tcgtgaaaga      540

ggaactggcc ctgctggatg ggtccaacgt ggtctttaaa cttctgggtc cggtgctagt      600

caaacaggag ctgggggagg ctcgggccac agtagggaag aggctggact atatcacagc      660

tgaaattaag cgatacgaat cccagcttcg ggatcttgag cggcagtcag agcaacagag      720

ggagaccctt gctcagctgc agcaggagtt ccagcgggcc caggcagcaa aggcaggggc      780

tcctggcaag gcctgacccc atggtggggg gaggggaggg gaggggaggg aatgaggcag      840

ctctaggatc tatactgtag ctaataaaat gtaaaaacac ctgg                       884


<210> 2371
<211> 2682
<212> DNA
<213> Homo sapiens

<400> 2371
tttttttttt tagacagagt cttgctctgt tgcggaggct ggagtgcagt gatctcagct       60

cactggaagc tccgcctcct gggttcaagc gattctccta tctcaacctc ccaagtgtgc      120

caccacacct gccgaatgtt tgtgttttta gtagggatgg ggttcgccat gttgggcagg      180

ctggtctcaa actcctgacc tcaagtgatc tgcccgcctc ggcctcccag agtgctggga      240

ttataggcgt gagccaccat gcctggacat gaccctgtct ctaaaacaat gtaatgaact      300

gcagctcatt cttgtgtgca cttttctgca ccccctttcc cttaacactt actattgtct      360

ggcatgctac gtgttttctt gatctcatta gcctctccca ccccaactgc cacactgcac      420

tatcagaggg cagcacttat cactgctgta gaacaaagtc ctgcactgag ccgatggccc      480

agaaattttc tttttattta tttatttatt ttttttttga gacagagtct tactctgtcg      540

ctcaggctgg agtgtagtgg cgcgatctca gctcactgca acctctgcct cctggtttca      600

agcaattctc cttcctcagc ctccagagta gctgggatta cacgcgcctg ccaccgcgcc      660

tggctaattt ttgtattttt agtagagatg gggtttcaac catgttggcc aggctggtct      720

caaactcctg acctcaggtg atcctgccca cctaagcctc ccaaaatgct ggtattacag      780

gcatgagcca ccgtgcccgg cctaaatatt taataaaata atggacgatg ggtgccttct      840

actgagctcc cggtaattgt gagtgagtag aggacttgcc ctggggacat tcagtgacct      900

gctgggtgtt gctgagctgt gaggaagttc aggtctggct gcagtggtga ggctgtgact      960

caatcaatca ctgctgatgc tcccaggacc tgcaccagct tagtcctagg ggcaaggatt     1020

ttaactgtcc acctcagttt cttcatttgt aagatgcaaa taacagtcac ccctgcctca     1080

tgggatggag ctgtgtaatg cccgcaacag tgcctgctgc atagaggggt tgctgccagc     1140

tgcctctccc tccttgtctc ttacctgcct gctgcctggg tcaggatgaa gaggggccct     1200

tgtgttgccc ccaccctggc tgcctgctaa gggcccatgt gatctgcctg gcagaggagt     1260

ttcttcagga agaaccaggg cagcttctgc ccctagaggg ccaatgccct tgctgtgaga     1320

agtcactgct ttggggagac ctgatctggc tgtgccagat ggacactgag aaagaagtag     1380

aagactcaga attagaagag gaacatggag ctgatccagg acacctcccg cccgccactg     1440

gagtacgtga agggggtccc gctcatcaag tactttgcag aggcactggg gcccctgcag     1500

agcttccaag cccgacctga tgacctgctc atcaacacct accccaagtc tggcaccacc     1560

tgggtgagcc agatactgga catgatctac cagggcggcg acctagagaa gtgtaaccgg     1620

gctcccatct acgtacgggt gcccttcctt gaggtcaatg atccagggga accctcaggg     1680

ctggagactc tgaaagacac accgccccca cggctcatca agtcacacct gcccctggct     1740

ctgctccctc agactctgtt ggatcagaag gtcaaggtgg tctatgttgc ccgaaaccca     1800

aaggacgtgg cggtctccta ctaccatttc caccgtatgg aaaaggcgca ccctgagcct     1860

gggacctggg acagcttcct ggaaaagttc atggctggag aagtgtccta cgggtcctgg     1920

taccagcacg tgcaggagtg gtgggagctg agccgcaccc accctgttct ctacctcttc     1980

tatgaagaca tgaaggagaa ccccaaaagg gagattcaaa agatcctgga gtttgtgggg     2040

cgctccctgc cagaggagac catggacttc atggttcagc acacgtcgtt caaggagatg     2100

aagaagaacc ctatgaccaa ctacaccacc gtcccccagg agctcatgga ccacagcatc     2160

tcccccttca tgaggaaagg catggctggg gactggaaga ccaccttcac cgtggcgcag     2220

aatgagcgct tcgatgcgga ctatgcggag aagatggcag gctgcagcct cagcttccgc     2280

tctgagctgt gagaggggct cctggagtca ctgcagaggg agtgtgcgaa tctaccctga     2340

ccaatgggct caagaataaa gtatgatttt tgagtcaggc acagtggctc atgtctgcaa     2400

tcccagcgat ttgggaggtt gagctggtag gatcacaata ggccacgaat ttgagaccag     2460

cctggtaaaa tagtgagacc tcatctctac aaagatgtaa aaaaattagc cacatgtgct     2520

ggcacttacc tgtagtccca gctacttggg aagcagaggc tggaggatca tttcagccca     2580

ggaggttgtg gatacagtga gttatgacat gcccattcac tacagcctgg atgacaagca     2640

agaccctccc tccaaagaaa ataaagctca attaaaataa aa                        2682


<210> 2372
<211> 1413
<212> DNA
<213> Homo sapiens

<400> 2372
acactggacc ttcaaaaccc tcagggcaga gagcagccct acactcccta caccacaccc       60

atactcagcc cctgcaggca aggagagaac aggtcaggtt cccgagagct caggaacatg      120

gagctgatcc aggacacctc ccgcccgcca ctggagtacg tgaagggggt cccgctcatc      180

aagtactttg cagaggcact ggggcccctg cagagcttcc aagcccgacc tgatgacctg      240

ctcatcaaca cctaccccaa gtctggcacc acctgggtga gccagatact ggacatgatc      300

taccagggcg gcgacctaga gaagtgtaac cgggctccca tctacgtacg ggtgcccttc      360

cttgaggtca atgatccagg ggaaccctca gggctggaga ctctgaaaga cacaccgccc      420

ccacggctca tcaagtcaca cctgcccctg gctctgctcc ctcagactct gttggatcag      480

aaggtcaagg tggtctatgt tgcccgaaac ccaaaggacg tggcggtctc ctactaccat      540

ttccaccgta tggaaaaggc gcaccctgag cctgggacct gggacagctt cctggaaaag      600

ttcatggctg gagaagtgtc ctacgggtcc tggtaccagc acgtgcagga gtggtgggag      660

ctgagccgca cccaccctgt tctctacctc ttctatgaag acatgaagga gaaccccaaa      720

agggagattc aaaagatcct ggagtttgtg gggcgctccc tgccagagga gaccatggac      780

ttcatggttc agcacacgtc gttcaaggag atgaagaaga accctatgac caactacacc      840

accgtccccc aggagctcat ggaccacagc atctccccct tcatgaggaa aggcatggct      900

ggggactgga agaccacctt caccgtggcg cagaatgagc gcttcgatgc ggactatgcg      960

gagaagatgg caggctgcag cctcagcttc cgctctgagc tgtgagaggg gctcctggag     1020

tcactgcaga gggagtgtgc gaatctaccc tgaccaatgg gctcaagaat aaagtatgat     1080

ttttgagtca ggcacagtgg ctcatgtctg caatcccagc gatttgggag gttgagctgg     1140

taggatcaca ataggccacg aatttgagac cagcctggta aaatagtgag acctcatctc     1200

tacaaagatg taaaaaaatt agccacatgt gctggcactt acctgtagtc ccagctactt     1260

gggaagcaga ggctggagga tcatttcagc ccaggaggtt gtggatacag tgagttatga     1320

catgcccatt cactacagcc tggatgacaa gcaagaccct ccctccaaag aaaataaagc     1380

tcaattaaaa taaaatatga tttgtgttca tgt                                  1413


<210> 2373
<211> 3113
<212> DNA
<213> Homo sapiens

<400> 2373
cttccccgcc cgctccatcc gggtcgctga cggctgtctc tggactggac agcagtggcg       60

tccgcttttc tctaaggaac ccgataagaa ctccattttc tgttgatgtg gagacatagg      120

gtacctccaa ctttccgggg tttcagaaga gaatttttta ttgaaactgg aagaccaaaa      180

taattacaag catgttgtgc tggggaaatg catcctttgg gcagctaggt ttgggtggaa      240

ttgatgaaga aattgtacta gagcccagaa aaagtgactt ctttataaat aaaagggtcc      300

gagatgtagg atgtggactc agacatactg tgtttgttct ggatgatgga acagtgtaca      360

catgtggatg taatgatcta ggacagctag gtcatgaaaa atccagaaag aaaccagaaa      420

tattaaaagt ttgtcagata tccagattgt acaggttgct tgtggttact atcattcact      480

tgcactttct aaagcaagtg aagtcttctg ttggggacag aataaatatg gccaattggg      540

tttaggtact gactgtaaaa agcaaacttc accgcagctg cttaagtctt tgcttggaat      600

ccctttcatg caagttgcag caggaggagc ccatagtttt gtactcaccc tttctggagc      660

tatctttgga tggggacgca acaagtttgg tcagctaggt cttaatgatg aaaatgatag      720

gtatgttcct aatttactaa agtcactaag atctcagaaa atagtttata tttgttgtgg      780

agaagatcat actgctgctc taaccaagga aggtggagtg tttacttttg gagctggagg      840

gtatggtcag ttgggccata attctaccag tcatgaaata aacccaagga aagtttttga      900

acttatggga agcattgtca ctgagattgc ttgtggacgg cagcacactt ctgcttttgt      960

tccttcatca ggacgaattt actcttttgg gcttggtggt aatgggcagc tgggaaccgg     1020

ttcaacaagc aacaggaaaa gcccctttac tgtaaaagga aattggtacc cctataatgg     1080

gcagtgtcta ccagatattg attctgaaga atatttctgt gtaaaaagaa ttttctcagg     1140

gggagatcaa agcttttcac attactctag tccccagaac tgtgggccac cagatgactt     1200

cagatgtccc aatccgacaa agcagatctg gacagtgaat gaagctctaa ttcagaaatg     1260

gctgagctat ccttctggaa ggtttcctgt ggagatagcc aatgagatag atggaacgtt     1320

ttcttcctct ggttgcctaa atggaagttt tttagctgtt agcaatgatg atcactatag     1380

aacaggtacc agattttcag gggttgatat gaatgctgct aggcttttat tccacaaact     1440

tatacaacct gatcatccgc agatatctca gcaggtggca gctagtttgg aaaagaatct     1500

tattcctaaa ctgactagct ccttacctga tgttgaagca ttgaggtttt atcttactct     1560

accagaatgt cccctgatga gtgattccaa caatttcaca acaatagcaa ttccctttgg     1620

tacagctctt gtgaacctag aaaaggcacc actgaaagta cttgaaaact ggtggtcagt     1680

acttgaacct ccactattcc tcaagatagt agaacttttt aaggaagttg tggtacatct     1740

tttgaaactc tacaagatcg gtattccccc ttctgaaaga agaattttca acagttttct     1800

tcatactgca ttaaaggttt tagaaatact acatagggta aatgagaaaa tgggacagat     1860

tatacagtat gataaatttt atatacatga agtacaagaa ttgatagaca taagaaatga     1920

ttatatcaac tgggtccaac agcaggccta tggaatgttg gcagatatcc ctgttacaat     1980

ctgtacatat ccatttgtat ttgatgccca agcaaaaact actctgttac agaccgatgc     2040

agtcttacag atgcagatgg ctattgatca ggcccacagg cagaatgtct cctctctttt     2100

tctcccagtg attgaatctg tgaatccctg cttaattcta gtggtgcgta gagaaaatat     2160

tgtaggagat gcaatggaag tccttaggaa aacaaagaac atagattaca agaagccact     2220

caaggttata tttgttggag aagatgctgt ggatgcagga ggggtgcgca aagaattttt     2280

cttgctcatc atgagggaat tattggatcc taaatacggc atgtttaggt attatgaaga     2340

ttccaggctc atttggtttt ctgataagac atttgaagac agtgatttgt tccatttgat     2400

tggtgttatc tgtggcttag caatttataa ttgtaccatt gtggacctcc attttccttt     2460

ggctttatat aagaaactac tgaaaaagaa gccatccttg gatgatttga aagaactaat     2520

gcctgatgtt gggagaagca tgcaacagtt actggattat ccagaagatg acatagagga     2580

aacattttgt cttaatttta cgatcacagt tgaaaacttt ggtgcaacag aagtgaaaga     2640

gctggttcta aatggtgcag acacagctgt taacaaacaa aatcggcaag agtttgtcga     2700

tgcttatgtg gattacatat tcaataaatc agtggcttcc ttatttgatg cttttcatgc     2760

gggctttcat aaggtctgtg gaggaaaagt ccttctgctc tttcagccta atgaactaca     2820

agcaatggtc attggaaata caaattatga ttggaaggaa ctggaaaaga atacagaata     2880

caaaggggaa tattgggcag aacatcctac gataaaaatt ttttgggaag tatttcacga     2940

attaccattg gaaaagaaga aacagtttct gttatttttg acaggtagtg atcgcattcc     3000

tattcttggt atgaagagtc tgaaactagt catccagtcc acaggaggtg gtgaggagta     3060

tctcccagtt tcccatactt gttttaatct tctggatctt ccaaaatata cag            3113


<210> 2374
<211> 4445
<212> DNA
<213> Homo sapiens

<400> 2374
agtctcttcc ccaactctcc ccacccctgg tgctctccgc cccgcttgcc tcccgttctt       60

ccccgcccgc tccatccggg tcgctgacgg ctgtctctgg actggacagc agtggcgtcc      120

gcttttctct aaggaacccg ataagaactc cattttctgt tgatgtggag acatagggta      180

cctccaactt tccggggttt cagaagagaa ttttttattg aaactggaag accaaaataa      240

ttacaagcat gttgtgctgg ggaaatgcat cctttgggca gctaggtttg ggtggaattg      300

atgaagaaat tgtactagag cccagaaaaa gtgacttctt tataaataaa agggtccgag      360

atgtaggatg tggactcaga catactgtgt ttgttctgga tgatggaaca gtgtacacat      420

gtggatgtaa tgatctagga cagctaggtc atgaaaaatc cagaaagaaa ccagagcagg      480

ttgttgccct ggatgcccaa aatattgtag ctgtttcatg tggagaagct catacgttag      540

cgctaaatga caaaggccag gtgtatgctt ggggtctcga ttctgatgga cagcttggcc      600

tggtaggatc agaggaatgc atcagagtac ccagaaatat taaaagtttg tcagatatcc      660

agattgtaca ggttgcttgt ggttactatc attcacttgc actttctaaa gcaagtgaag      720

tcttctgttg gggacagaat aaatatggcc aattgggttt aggtactgac tgtaaaaagc      780

aaacttcacc gcagctgctt aagtctttgc ttggaatccc tttcatgcaa gttgcagcag      840

gaggagccca tagttttgta ctcacccttt ctggagctat ctttggatgg ggacgcaaca      900

agtttggtca gctaggtctt aatgatgaaa atgataggta tgttcctaat ttactaaagt      960

cactaagatc tcagaaaata gtttatattt gttgtggaga agatcatact gctgctctaa     1020

ccaaggaagg tggagtgttt acttttggag ctggagggta tggtcagttg ggccataatt     1080

ctaccagtca tgaaataaac ccaaggaaag tttttgaact tatgggaagc attgtcactg     1140

agattgcttg tggacggcag cacacttctg cttttgttcc ttcatcagga cgaatttact     1200

cttttgggct tggtggtaat gggcagctgg gaaccggttc aacaagcaac aggaaaagcc     1260

cctttactgt aaaaggaaat tggtacccct ataatgggca gtgtctacca gatattgatt     1320

ctgaagaata tttctgtgta aaaagaattt tctcaggggg agatcaaagc ttttcacatt     1380

actctagtcc ccagaactgt gggccaccag atgacttcag atgtcccaat ccgacaaagc     1440

agatctggac agtgaatgaa gctctaattc agaaatggct gagctatcct tctggaaggt     1500

ttcctgtgga gatagccaat gagatagatg gaacgttttc ttcctctggt tgcctaaatg     1560

gaagtttttt agctgttagc aatgatgatc actatagaac aggtaccaga ttttcagggg     1620

ttgatatgaa tgctgctagg cttttattcc acaaacttat acaacctgat catccgcaga     1680

tatctcagca ggtggcagct agtttggaaa agaatcttat tcctaaactg actagctcct     1740

tacctgatgt tgaagcattg aggttttatc ttactctacc agaatgtccc ctgatgagtg     1800

attccaacaa tttcacaaca atagcaattc cctttggtac agctcttgtg aacctagaaa     1860

aggcaccact gaaagtactt gaaaactggt ggtcagtact tgaacctcca ctattcctca     1920

agatagtaga actttttaag gaagttgtgg tacatctttt gaaactctac aagatcggta     1980

ttcccccttc tgaaagaaga attttcaaca gttttcttca tactgcatta aaggttttag     2040

aaatactaca tagggtaaat gagaaaatgg gacagattat acagtatgat aaattttata     2100

tacatgaagt acaagaattg atagacataa gaaatgatta tatcaactgg gtccaacagc     2160

aggcctatgg aatggatgtc aaccatggat taactgagtt ggcagatatc cctgttacaa     2220

tctgtacata tccatttgta tttgatgccc aagcaaaaac tactctgtta cagaccgatg     2280

cagtcttaca gatgcagatg gctattgatc aggcccacag gcagaatgtc tcctctcttt     2340

ttctcccagt gattgaatct gtgaatccct gcttaattct agtggtgcgt agagaaaata     2400

ttgtaggaga tgcaatggaa gtccttagga aaacaaagaa catagattac aagaagccac     2460

tcaaggttat atttgttgga gaagatgctg tggatgcagg aggggtgcgc aaagaatttt     2520

tcttgctcat catgagggaa ttattggatc ctaaatacgg catgtttagg tattatgaag     2580

attccaggct catttggttt tctgataaga catttgaaga cagtgatttg ttccatttga     2640

ttggtgttat ctgtggctta gcaatttata attgtaccat tgtggacctc cattttcctt     2700

tggctttata taagaaacta ctgaaaaaga agccatcctt ggatgatttg aaagaactaa     2760

tgcctgatgt tgggagaagc atgcaacagt tactggatta tccagaagat gacatagagg     2820

aaacattttg tcttaatttt acgatcacag ttgaaaactt tggtgcaaca gaagtgaaag     2880

agctggttct aaatggtgca gacacagctg ttaacaaaca aaatcggcaa gagtttgtcg     2940

atgcttatgt ggattacata ttcaataaat cagtggcttc cttatttgat gcttttcatg     3000

cgggctttca taaggtctgt ggaggaaaag tccttctgct ctttcagcct aatgaactac     3060

aagcaatggt cattggaaat acaaattatg attggaagga actggaaaag aatacagaat     3120

acaaagggga atattgggca gaacatccta cgataaaaat tttttgggaa gtatttcacg     3180

aattaccatt ggaaaagaag aaacagtttc tgttattttt gacaggtagt gatcgcattc     3240

ctattcttgg tatgaagagt ctgaaactag tcatccagtc cacaggaggt ggtgaggagt     3300

atctcccagt ttcccatact tgttttaatc ttctggatct tccaaaatat acagaaaaag     3360

aaactctacg ctctaaactg atccaagcta ttgatcacaa tgaaggcttc agtttaatat     3420

aactttggag ttataactat tcagtttagt gcaaaagcat taaactattt gtgtttttct     3480

tgtggtgatg aattcagcaa ggtgacagag gtactattat aattcttact tgcagaatgt     3540

tcaatctacg agtgttcatg gaagccaaaa aatattaaag gaaaatgaac aaactgttaa     3600

tattattgta cagaaccatg gatttttttt gaccatcttc taataaacat agcaagtatt     3660

atgaatacat taaagtttta ctaacatgaa ttttaagagt ttgcatattt cagaaatgat     3720

ctggtgtgag tgcatggaaa tattgcttaa tttttcttca atcattgagt gaaaaacctt     3780

taactttggc ctgcaatagt catttgatta ttttttcatt ttgtaaataa tgttaagttt     3840

tgtaataaaa tagttatgtt ctgataccag tacagtttct atggttgtaa ttgaacttga     3900

acagactttt aaaggttaaa aattatgatt taaatcttac tctgagactc tataaaaaga     3960

aaaaaaaggt agcatggtgg aaacactatc ttttcttttt tgctagaata agtgtctttg     4020

tgcaaaccta aatcacagat agggaatata ctacataacc tgcagttctt ttctttgtga     4080

atcctgacac actgatagat gggggattgt cgatcagaga acttattaat atttagtact     4140

ggaagaactc tgtctccaca gttgccagta ataaaaagaa acattggcta ctatgagcac     4200

caatcactgg gttatagctt tcaaaattat tgatgctgca gtgctttaga gctatttcct     4260

tgaatttaag aaacaaatct taacagtttt atggtgctga tgcttagttg tctcatgcca     4320

ttaaattgta aaagtgagtt gatgcaatac atgtgacttt ctgctataat gcaaatattt     4380

attttttaaa tttattttaa aatgccgtga aaactgttta ataaagattt attgttttaa     4440

tattt                                                                 4445


<210> 2375
<211> 3259
<212> DNA
<213> Homo sapiens

<400> 2375
agacaaaacg atcgcggtta aagcttgcgg ctcagagccc acctggccgc gctgctggga       60

aacggacgga gcggcgcttc aatcagaggt attactcagc acagaaattc aggagacaca      120

gacaagttct tccacgatgt cgtacagacg agaactagag aaataccgtg acctggatga      180

agatgaaatc cttggagccc taacagagga agagctgagg accctggaaa atgagctgga      240

tgagctggac cctgataatg cactgctgcc tgcaggcctg aggcagaagg atcagaccac      300

caaggcgccc acgggcccct ttaaaagaga ggagctcttg gatcacttgg aaaagcaagc      360

aaaggagttt aaggaccgag aagatctggt cccctacaca ggggaaaaac gaggaaaggt      420

ctgggttcct aagcagaagc cactggatcc tgtgctggaa agtgtgacgc tggaaccgga      480

gctggaggaa gccttggcaa atgcttcaga tgcagaactc tgtgacattg cagcgatcct      540

gggcatgcac acgctcatga gtaaccagca gtactaccag gccctgagca gcagctccat      600

catgaacaag gaggggctca acagcgtgat taaacccaca caatacaagc ctgtgcccga      660

cgaagaacca aattcaacag acgtagagga aacgctggaa cggataaaga acaacgaccc      720

aaaacttgaa gaagttaacc tcaataatat ccggaatatc cccatcccca ccctcaaggc      780

atatgcagaa gccctgaaag aaaactcata tgtgaagaag ttcagcatcg tggggacacg      840

gagtaatgac cccgtggcgt atgcccttgc tgagatgctc aaggagaaca aggtgttgaa      900

gacactgaat gtggaatcca acttcatttc tggagctggg attctgcgcc tggtagaagc      960

cctcccatac aacacttctc tggtggaaat gaaaattgac aaccagagcc agcccctggg     1020

caacaaagtg gaaatggaga ttgtgagcat gttggaaaaa aacgcaacac ttctcaaatt     1080

cggctaccac tttacccagc aaggaccccg gcttcgggca tccaacgcaa tgatgaacaa     1140

caatgacctt gtgaggaaga ggaggcttgc ggacctgact gggcccatca ttcccaagtg     1200

ccggagtggt gtctagtgtg tggcggtgga gtccatgcct ttgaactgga tgtgttctat     1260

tgatgacctg tgctctgcag gggaaaccag aaggcaaaat gctggcagca tgaaaccctt     1320

ttgtggttca gttctttatg cactaaggtt ttaggttgac tagtggttgt agttgaaaat     1380

tttataaaat accgttaatg tgaagttttt ctttagtcac agaagttgaa tctggttatt     1440

atttaaaaac tagaagcccc caaaccagca gatcttactg aagatgatgt tccagcagca     1500

gcgacttagc cccaggagcc cagtttcaat ggccttgctg tgtggtgttt caagtgcatt     1560

taaaatgtgt gacacagaaa cggcacactc ttccacatgc ttttgaagta ttataaaaca     1620

ctttattaca aatttgtctt agctattagc aaataaaact gattatcatt ctttattaac     1680

cctccttgga attttgaaaa cctcgattaa agttgccaaa ttgattactg gatccagaac     1740

acaattttcc cctcagaaca gatagacaga ctgaagccac tgaactctgc caggagtcaa     1800

catgagattc cttttgctgg atatgcagaa atgataggaa aaaaaccaat ggtgaaattt     1860

caagtttcaa aaaccaacct ttcattacca atcccaggca acaaacatgt ccctgagtgt     1920

tctttaagaa catttgggat ttatgtacaa tttaatactg gagttagaac tttttcctta     1980

ttgaatgcca accttatgat ggatgtgaaa atctacggcc aaatactttt gaaaacacct     2040

ttctatattg cacagtgggc aaatggctta tgtgaggtaa gacactagag ggataaattt     2100

ccagatcaac atggctatgg tatttagtaa tggcccagct tagagacttc agctactgat     2160

ctcatcactt attagacaaa ttgctgctga ccttacgcct gtatattaag cctccgcagg     2220

atgccggaca atggtgaaga aactccagat atcaaggaat tgggaaatcc tggccaaacc     2280

accccaagat gattacactg aaatgtagta ttagtactgc tgccagatct ctttttaaca     2340

tcatgtgcgt ctcttgggat ccagcaaaag tgttaagcca caatgccctt gtgcctttta     2400

atataccaca gtgccagtta aactaatatt tttgtttgtt gcttttggga gttattttca     2460

ttagtgattt cagcaaatct catgataaag gacaaggtca agaactccag agcactgagc     2520

agagaggctg gtgatgaaaa ggtgaaggcc tgcgcactga actgtaaggc agtgggcagt     2580

acagggtaac tggaggcggg gccagggcct cagcgctatg gaagagtgtc cactgaggct     2640

gcacatggcc caggagtggc accatgttgc agggacaacc atccccattt ggcttctcct     2700

taaaacacaa ttgcagctgc attctgcatc gctgaaaact gcaatataat attaaatctg     2760

ttggtctatg catggctgcg tatgtgtttc ttggaacctg tgtgacaggg acatgtgcct     2820

ggcacactgg ccagaagact gggcagccac catggcagtg ctggatgacc tcagtaagaa     2880

tgtgtcatgt attccaggtg ctgatctaaa aactgtggct caaatgtcac cgagcttata     2940

tgaagctccc agagagaaca tttaaaagct cagagagtaa gtgctgggga aagcagagct     3000

atcagaggaa atctctcata gaaacgaaac caaaccaaca gaaaatgaag aaggccacat     3060

ctttaaggcc acctctgcct ctatcagatg agctgctggt ctagatcagg ggctggcaaa     3120

cttttctgta aaaggccaga cagtaaaaat ttccgatttt gcaggccaca tagtgtctgt     3180

tgcaactatt caactctgcc atagatcatg tgtaaaggaa tgggtgtggc tgttcaataa     3240

actatacagt tgacccttg                                                  3259


<210> 2376
<211> 895
<212> DNA
<213> Homo sapiens

<400> 2376
cgcggcgcgg cgccggagga ggaagtggtg aggttgttgc tccttcagcg cctatcgctg       60

gctcttgggg cgcagagagg ggccgcagtc tccgcggctg cgtcgagctc ccttgcagtc      120

ccctccatgt tccccggcgc cactactccc cttcctaagg ccgccgctta ccccggggtc      180

tatggaagta atggaaggac ccctcaacct ggctcatcaa cagagcagac gagcagaccg      240

tttattagct gcaggcaaat acgaagaggc tatttcttgt cacaaaaagg ctgcagcata      300

tctttctgaa gccatgaagc tgacacagtc agagcaggct catctttcac tggaattgca      360

aagggatagc catatgaaac agctcctcct catccaagag agatggaaaa gggcccagcg      420

tgaagaaaga ttgaaagccc agcagaacac agtactttat ttacttcagc aaaagagtga      480

gccagcagag ccatgtattg gaagcaaagc cccaaaagat gataaaacaa ttatagagga      540

gcaggcaacc aaaattgcag atttgaagag gcatgtggaa ttccttgtgg ctgagaatga      600

aagattaagg aaagaaaata aacaactaaa ggctgaaaag gccagacttc taaaaggtcc      660

aatagaaaag gagctggatg tagatgctga ttttgtagaa acgtcagagt tatggagctt      720

gccaccacat gcagaaactg ctacagcctc ctcaacctgg cagaagttcg cagcaaatac      780

tgggaaagcc aaggacattc caatccccaa tcttcctccc ttggattttc catctccaga      840

acttcctctt atggagctct ctgaggatat tctgaaagga tttatgaata attaa           895


<210> 2377
<211> 7666
<212> DNA
<213> Homo sapiens

<400> 2377
ctcaaagaaa atgaacggca ccctggacca cccagaccaa ccagatcttg atgctatcaa       60

gatgtttgtg ggccaggttc caaggacctg gtctgaaaag gacttgcggg aactcttcga      120

acagtatggt gctgtgtatg aaatcaacgt cctaagggat aggagccaaa acccgcctca      180

gagcaaaggg tgctgttttg ttacatttta cacccgtaaa gctgcattag aagctcagaa      240

tgctcttcac aacatgaaag tcctcccagg gatgcatcac cctatacaga tgaaacctgc      300

tgacagtgag aagaacaatg tggaagacag gaagctgttt attggtatga tttccaagaa      360

gtgcactgaa aatgacatcc gagtcatgtt ctcttcgttt ggacagattg aagaatgccg      420

gatattgcgg ggacctgatg gcctgagccg aggttgtgca tttgtgactt ttacaacaag      480

agccatggca cagacggcta tcaaggcaat gcaccaagca cagaccatgg agggttgctc      540

atcacccatg gtggtaaaat ttgctgatac acagaaggac aaagaacaga agagaatggc      600

ccagcagctc cagcagcaga tgcagcaaat cagcgcagca tctgtgtggg gaaaccttgc      660

tggtctaaat actcttggac cccagtattt agcactttat ttgcagctcc ttcagcagac      720

tgcctcctct gggaacctca acaccctgag cagcctccac ccaatgggag ggttgaatgc      780

aatgcagtta cagaatttgg ctgcactagc tgctgcagct agtgcagctc agaacacacc      840

aagtggtacc aatgctctca ctacatccag cagtcccctc agcgtgctca ctagttcagg      900

gtcctcacct agctctagca gcagtaattc tgtcaacccc atagcctcac ttggagccct      960

gcagacatta gctggagcaa cggctggcct caatgttggc tctttggcag gaatggctgc     1020

tttaaatggt ggcctgggca gcagtggcct ttccaatggc accgggagca ccatggaggc     1080

cctcactcag gcctactcgg gtatccagca atatgctgct gctgcgctcc ccactctgta     1140

caaccagaat cttctgacac agcagagtat tggtgctgct ggaagccaga aggaaggtcc     1200

agagggagcc aacctgttca tctaccacct gccccaggag tttggtgatc aggacctgct     1260

gcagatgttt atgccctttg ggaatgtcgt gtctgccaag gttttcatag acaagcagac     1320

aaacctgagc aagtgttttg gttttgtaag ttacgacaat cctgtttcgg cccaagctgc     1380

catccagtcc atgaacggct ttcagattgg catgaagcgg cttaaagtgc agctcaaacg     1440

ttcgaagaat gacagcaagc cctactgagc gtgctcccct ctgagactgg agtgagaggg     1500

tcttctggca cagcttgccc tgaagactcg gctactgcct tctgtgggag tttcgcttcg     1560

tacagaggac aagtttgtgc tttggtttcc agtgttttac tttggagttt aggtgccata     1620

tcctgaggtt ttttttgttt ttgtttttgt ttctccttta tttaaagttt gctgtgtttg     1680

taaccagtgt gtgttgagaa ggaccaacac caaaccaccc tggggaaggg ggacagggaa     1740

acatttaaca cagacgatga tcaggatttg ccccaaacca ccccaagaga gaggactgag     1800

tggaacaaaa aagtgacccc cagaacctct cttagtgtga gggtgggtag aatgagaact     1860

gacacctggg agctgtgggg agcagagcgg ctttggggaa gagtggagtg actagacacc     1920

taatgccctg gcagctggag actcaaactc ctgtacagct accttctggg aaatagtttt     1980

tgacacctat ttttcagatt cttgtccgga atttctgctg ctcttttcaa aaaagggcat     2040

taacaattct ctggaaataa agcacctgtt agcctgacat atgcaaaaag cagggcggca     2100

tcacccatta cgagctcccc cagccagcag tcagtattgg attggccttg cctggctggt     2160

ggcagtttgg gagaaacagc caaagaggtt agtttatttc aacaccaaat tagaccatgg     2220

cccatttcca acgggtctct ttaaaggcct ctatggaata cattgcctgg tttccttctt     2280

tgcagttcac cacagcaagg aatgtcacct ccatcccaag ccaccatttt ctcatgaagg     2340

caaatccaag aagggcttgc agttcttgct gaagggggta ccatttgtgg gcagagtgat     2400

caataccatc tagttggggg aggaggagct tatttcttgg tgtacttgaa tcagaaggtc     2460

cctgcaagcc agtatgcttc atttgccagt ggccagaaat tctcccttgc ctccttgatt     2520

gaggtgtccc agatgtagta ttcccacagg ggtctggcag gcccctcctg taaccactcc     2580

agtcacattt tctgctcttg aggcagaggt gacatcagga cgtttacagc ctccacatga     2640

attgagtgtt catttacctc agtattaccg tgttcatttt tgtcctcgtg ctacagttag     2700

ctccctgccg cctcttgcag gtcttacttc agctcttgcc tgtgacccac acagcttctg     2760

ggctctgcct ctgctctaag aagtgctgtg ggggtagaga accaggaagg acatgctgtt     2820

gggaatgtac acctgggcag aggtggccct gttaagatgt gactgtagcc acagccaggg     2880

atgggatccc tgggtctctg gaatctgaaa cctcaacaaa taccagtctt gacccctagc     2940

agcagagata agaataaagg ggttggtttg ctattaagtc agatgggggc tctctccttg     3000

tcatgctgtc cctgtgggta acagacaggg attgaccatc ttactgttgt acaggtagct     3060

ggtggtgttg gattatccca ttgaagctgg gacagctgtt cctttctcat agtgataact     3120

tgggtctgtt gtcctctaag gaacgtgaaa catacacttc ttaagctgaa ccacgtaaac     3180

ttgaaattct gcgcactggg agaaatgtgt cctgtgtttc aaaggataaa actgttctaa     3240

aggcttccag ggtcatgatg ggatttttta aataaatgca aaaaataaaa ataaaaaaga     3300

aaaaagaaaa caaaaaaaaa aaagaaaaaa atgctaggtt ggggaggcgc tgttctgaat     3360

cccaaccggc tggaaccaag aatgtcgttt ctatttttat agaagtttta tacagctccg     3420

gggtggagaa tatttattac ctaaattata tctctggaaa aggccaggat tttgtagaat     3480

ccagaatgtg attgttatac acacagggtg ctgtgtatga ttgaaactac tgactttctg     3540

tggcccgttt gcagcccagc taacctgccc aaggggaagg tgttaatgct gtgaattggc     3600

agaggagaga gctgtgctcc atagggtgct gccggtgctg tgctccctag ccttctgttc     3660

tgtcttcctc cttagccaga acgccactcc cttcccacat ccccttcttc tctccgcctt     3720

cccccatctc accattattt gtccatggat ttgtcctggg ctctgggacc ttatgaaacc     3780

cctttcctaa tgacataaga ggccaaggtg caatccaccc acctttgata ccagaccctg     3840

agggcttcat acctgctgat gggttttctt ttctaaaagg aatgctcgcc ccagcagggt     3900

cctgggctgc ttgagcagcc agctggtgag accatgcact tctctgttct ctcctccccc     3960

tgcccagtga gttagcacag cagtagcact gcccttgagc acagttcttt ccccaggcca     4020

aagatggttt tgtgaagaag ctgctcccct acaagtctca cgtgtgaaag ggctcagctc     4080

agagtggaga ctcgctgtca agtcttaagc aatccttttc tgttgtgtga aggtttcact     4140

tacaatgtgt tttctgctgt agttttgttt cttacttggg ttacatcatg aaattgattt     4200

gccttgaatg cagccagacc actgtctcct gggttcccct tgagtggcca gggcctggat     4260

ggaagctaag agcttggatt tctgggaaca aagggccatc cccataagat tgagcagaaa     4320

ttctggtcct cttccctgaa aaattttccc caccccagcc agcatcttct gcttcccctt     4380

gggttgtgac cagggagtgg ggagagaggc tgaggctctg ctcccctgga gaccttctct     4440

taggagttgg gtgcttcatg gaaaatccaa gccttaggtt cccttctgtc tctggcaatt     4500

agatgtgttc ttggtgtcct ccatgtcctt tttgactttt ccctgtgtcc attgttagca     4560

tgtgcaaaag ttccctgtca ttacccaacc cctgcccgcc cacctcattt cagggctgta     4620

cacacagtga gtgttcctgt tctctctctc tttgtttgga tgtattgctc tgtgtaactc     4680

agtgggtctc cctctttctg gtttgttttt ttttctagat tcctgccgtt tgttcatcgt     4740

tgtgcctaaa gcatgtcgat gtggcgtcaa gtacatcgtc caaatccctg tctcttcagc     4800

ttctctgatg cttgaactct cacctttgac cttgtgttga cctttgatgc tgatgtgtat     4860

ttttattatg tttgtttctt tcttcgtttt tttttctttt tttctttcct ttttttttcc     4920

ttttgtgctg ccaaattggt tttgctagaa cgactgctga aggggaaata tttaaacttg     4980

catttgaata taaaaaaaat ctatttttct agaacttcat aagataacca cttgattttg     5040

tgattccaat tctttgtaat tgtcttcaga gcagccctac tagcacatac cgcgtggtgt     5100

ttgtatttct gtgaacacac agccagtccg tttctaggct ttgtttctct gtgtgcttag     5160

ttttaaagac aactttgaag taaacaatga aataaaagat gtcactaaaa cctctgaggc     5220

tcctgagcac attttgctga tacagtctgt ggggcttgag gagaccgcat gtattgttct     5280

ttcttttgtt tttcttctga gttctcaact gcggagagca cctgaacccc ctttcctttt     5340

tgaccgcagg ctgcactttg ggccccagcc agcccttttt ctttttcttt ttcttttgtg     5400

gttcttccct ggagcgactc tggggagtcc tggatatccc gcctgcccct tcccctcagc     5460

cccatgcttg ttccaacagt ctccacagca aaatgtgatg ctttgatttt tttgttgttg     5520

tttttgtttt tgtattgttt ttgtgttttt gttttgaatt ttttcctttc ctactaagat     5580

tatgcccaga aaaaagtttt gcatgtttcc tgctgtttct tcacaccttc gtatatatca     5640

ccttcacctc tctgttttct atagtttgtg caaaaactga tcgatttaaa agggtttcaa     5700

agaagctgtt ttaaattgtt gtagggttga ttattttttt caagattgta ttgtttaatt     5760

ttgaagtggc aactttctcc tctattgccc ttagagcgtt tgcctgtgca cttagactgt     5820

cacttcgtgt ggcctccagg tcttaccggg gcttccggga ggctggctgc tttgctcaga     5880

gagggtggga agggggcctg gagagacacg agaagcagag gtagagccta gaaggtggca     5940

gcaggtgggt aagaggctta tttagcacat taggggcagt gagcacctgg aggaaggagg     6000

gcgctcccaa tcacccgtag gaggccatct gcacaccaag cggcaattca cctgctggcg     6060

cttttcctag gtgacaagca caatactaca gtcttcacac tgtttacagc cctgggcacc     6120

agccacccgg cactggctct tcatcacagc tctgctcttg cttagctagt ggggtggggg     6180

aaagggcagg gatttgtttt tttaattggg tggagagcca aacagctact gtccctgggt     6240

gccaagcaag ccagtttttt ggttccctga gggaaactga ccctcctctc ttgtggcacc     6300

atccagcctc agggtcttgg agacttgagt aagaatgtga gtggaggggg agaggtgagg     6360

agaggagcac agggtggatc tgtggaggga agaggttaca gggggaggag ctgatgatag     6420

atcccaccca gacttaagct gctggtgggt gggtgagctg ggaagtagga ctgtccaggg     6480

aagggtggag agatgtagct aggggctggg gagggggagg tggaagcgct attgagcatc     6540

ctccacacca aggttgatga aggaagggat cccagcaggg tttctgctct ggggctggca     6600

ggttgcctgg tattatgccc aaggccgctc tgcctggggg aaagggcagc caggcagagg     6660

cccagtgtct ggtaggctgc tgaatttcct ggaaggggtg attggatgga aagaggccag     6720

aaaccccagc ctgagagact gctgtgcacc ccacagtctg actgcacaga gccgcctctg     6780

ttggcaggag gcactgaggc tccccttcct gtgtattgag aagcagtgtt tgccaatata     6840

ttttgctttc aattccaaga ggagctctgg gaaaacctgt ggataaaacc aaatgccaaa     6900

tgttggacgt tgtttccttt tccttttctc tctctgattg ttttaattgt tctgtggtgg     6960

ttttaatgga tttgagaccc tggagcggca gctgcctttc tgatttccag ctgctttttg     7020

tgaataattt aaaaagaaaa aaaaaaagaa actttacatt ttggagacaa acctgtgtga     7080

gttttttatt ggtacaaacg ttgtatttaa cactaggggt tttgtacagt tttttgcctt     7140

ttctactaga aaacaatgta aagtgatttc acaatgtgaa gagaaaaaaa aattgccact     7200

atgaccaaac gcacagtctg ttctgcagca acaacgggat tcaatcaact cagtcgtgat     7260

tcagccgtag aaatgctttt cctttatctt gtttgagctt ttcctttctt tcctgttttg     7320

atttgcaaaa gaaaatgtct tttttgtgtg aacttgtgtt gtactctgta gaaaattatg     7380

gattttactt taatggttta aaaaaaggca aggagagccc tcgtcgcttt tcttacctaa     7440

tcacagagtt tgtgtagtga atttaaaaag aaaaaaaaat tgttataagt ttggagcaag     7500

ggagtatgtg tttcaaagga atctccttcc tttttttgtg tgtttttcct tttgtcccaa     7560

tggggaacct aaatctgttt taattgcaca gacacatgga caaaaagtca ttttgtatct     7620

gccaagtgtg gtaccttcct ttgtttattt gctattaaac tgtttg                    7666


<210> 2378
<211> 2191
<212> DNA
<213> Homo sapiens

<400> 2378
atactttgaa aataacagct cttttttgtt ccctcgtgtg tctcttccca attgtatccc       60

tattgtattt tctcatagta tgtttcagca gaaatcaagg tagacgaagt aacctcttgt      120

cctgaatttt catagttgct cattcttaat aatggcagca gaagcaacaa tgagagtaac      180

tacctcctca gctcaaagaa aatgaacggc accctggacc acccagacca accagatctt      240

gatgctatca agatgtttgt gggccaggtt ccaaggacct ggtctgaaaa ggacttgcgg      300

gaactcttcg aacagtatgg tgctgtgtat gaaatcaacg tcctaaggga taggagccaa      360

aacccgcctc agagcaaagg gtgctgtttt gttacatttt acacccgtaa agctgcatta      420

gaagctcaga atgctcttca caacatgaaa gtcctcccag ggatgcatca ccctatacag      480

atgaaacctg ctgacagtga gaagaacaat gcagtggaag acaggaagct gtttattggt      540

atgatttcca agaagtgcac tgaaaatgac atccgagtca tgttctcttc gtttggacag      600

attgaagaat gccggatatt gcggggacct gatggcctga gccgaggttg tgcatttgtg      660

acttttacaa caagagccat ggcacagacg gctatcaagg caatgcacca agcacagacc      720

atggagggtt gctcatcacc catggtggta aaatttgctg atacacagaa ggacaaagaa      780

cagaagagaa tggcccagca gctccagcag cagatgcagc aaatcagcgc agcatctgtg      840

tggggaaacc ttgctggtct aaatactctt ggaccccagt atttagcact ccttcagcag      900

actgcctcct ctgggaacct caacaccctg agcagcctcc acccaatggg agggttgaat      960

gcaatgcagt tacagaattt ggctgcacta gctgctgcag ctagtgcagc tcagaacaca     1020

ccaagtggta ccaatgctct cactacatcc agcagtcccc tcagcgtgct cactagttca     1080

gcagggtcct cacctagctc tagcagcagt aattctgtca accccatagc ctcacttgga     1140

gccctgcaga cattagctgg agcaacggct ggcctcaatg ttggctcttt ggcaggaatg     1200

gctgctttaa atggtggcct gggcagcagt ggcctttcca atggcaccgg gagcaccatg     1260

gaggccctca ctcaggccta ctcgggtatc cagcaatatg ctgctgctgc gctccccact     1320

ctgtacaacc agaatcttct gacacagcag agtattggtg ctgctggaag ccagaaggaa     1380

ggtccagagg gagccaacct gttcatctac cacctgcccc aggagtttgg tgatcaggac     1440

ctgctgcaga tgtttatgcc ctttgggaat gtcgtgtctg ccaaggtttt catagacaag     1500

cagacaaacc tgagcaagtg ttttggtttt gtaagttacg acaatcctgt ttcggcccaa     1560

gctgccatcc agtccatgaa cggctttcag attggcatga agcggcttaa agtgcagctc     1620

aaacgttcga agaatgacag caagccctac tgagcgtgct cccctctgag actggagtga     1680

gagggtcttc tgattcctgc cgtttgttca tcgttgtgcc taaagcatgt cgatgtggcg     1740

tcaagtacat cgtccaaatc cctgtctctt cagcttctct gatgcttgaa ctctcacctt     1800

tgaccttgtg ttgacctttg atgctgatgt gtatttttat tatgtttgtt tctttcttcg     1860

tttttttttc tttttttctt tccttttttt ttccttttgt gctgccaaat tggttttgct     1920

agaacgactg ctgaagggga aatatttaaa cttgcatttg aatataaaaa aaatctattt     1980

ttctagaact tcataagata accacttgat tttgtgattc caattctttg taattgtctt     2040

cagagcagcc ctactagcac ataccgcgtg gtgtttgtat ttctgtgaac acacagccag     2100

tccgtttcta ggctttgttt ctctgtgtgc ttagttttaa agacaacttt gaagtaaaca     2160

atgaaataaa agatgtcact aaaacctctg a                                    2191


<210> 2379
<211> 7610
<212> DNA
<213> Homo sapiens

<400> 2379
cacgcactac gggttggcgc cagagtcaaa aggcgtcggc cctctggcaa gatggctgct       60

gcggaggcgt tggagcgcgg aaatctggaa ccgggatggc gacgtctaca ctgagtcgga      120

ggcgaaggag cttactccac gggaacagcc tctagataat ctgagttgtt gaaaatacga      180

agcctgttac tcgtgaacag tggctgacaa cagtgttgtt gtgagcctgg ctgtctgctt      240

ggacccagag gtttcgtctg ccagggtttt tggttgtatt taggatttca gggaaaagtg      300

tccaagcttt cagtgttgga gcaggtatgg acgacaaagg cgacccgagc aatgaggagg      360

cacctaaggc catcaaaccc accagcaaag agttcaggaa aacatggggt tttcgaagga      420

ccactatcgc caagcgagag ggcgcagggg acgcggaggc tgacccactg gagccgccac      480

ccccacagca gcagctgggc ctgtccctgc ggcgcagtgg gaggcagccc aagcgcactg      540

agcgcgtgga gcagttcctg accattgcgc ggcgccgcgg caggaggagc atgcctgtct      600

ccctggagga ttctggtgag cccacgtcct gccccgccac agacgccgag acagcctccg      660

agggcagcgt ggaaagcgct tctgagacca gaagcggccc ccagtctgct tccacagctg      720

tgaaggaacg accagcctct tctgaaaagg tgaaaggagg ggatgaccac gatgacacct      780

ccgatagtga cagcgatggc ctgaccttga aagagcttca gaatcgcctt cgcaggaagc      840

gggaacagga gcccactgag aggcccctga aagggatcca gagtcgcctg cggaagaagc      900

gccgggagga gggtcccgcc gagactgtgg gctccgaggc cagtgacact gtggagggcg      960

tcctgcccag taagcaggag cccgagaacg atcagggggt tgtgtcccag gctgggaaag     1020

atgacagaga gagtaagttg gagggaaagg cggctcagga catcaaagat gaggagcctg     1080

gagacttggg ccgaccgaag cctgaatgtg agggttacga ccccaacgcc ctgtattgca     1140

tttgccgcca gcctcacaac aacaggttta tgatttgctg tgaccgctgt gaagaatggt     1200

ttcatggcga ttgtgtgggc atttctgagg ctcgagggag gcttttggaa aggaatgggg     1260

aagactatat ctgcccaaac tgcaccattc tgcaagtgca ggatgagact cattcagaaa     1320

cggcagatca gcaggaagct aaatggagac ctggagatgc tgatggcacc gattgtacaa     1380

gtataggaac aatagagcag aagtctagcg aagaccaagg gataaagggt agaattgaga     1440

aagctgcaaa tccaagtggc aagaagaaac tcaagatctt ccagcctgtg atagaggcgc     1500

ctggtgcctc aaaatgtatt ggccccgggt gctgtcacgt ggcgcagccc gactcggtgt     1560

actgcagtaa tgactgtatc ctcaaacacg ccgcagcgac aatgaagttt ctaagctcag     1620

gtaaagaaca gaagccaaag cctaaagaaa agatgaagat gaagccagag aagcccagtc     1680

ttccgaaatg cggtgctcag gcaggtatta aaatctcttc tgtgcacaag agaccagctc     1740

cagaaaaaaa agagaccaca gtgaagaagg cagtggtggt ccctgcgcgg agtgaagcac     1800

tcgggaagga agcagcttgt gagagcagca cgccgtcgtg ggcgagcgat cacaattaca     1860

atgcagtaaa gccagaaaag actgctgctc cctcgccgtc actgttgtat aaatccacga     1920

aggaagacag gaggtccgag gagaaagcgg cagccatggc agcctcaaag aaaacagccc     1980

ctccaggctc cgcggtgggc aagcagcctg cacctagaaa cctcgtgcca aagaagtctt     2040

cttttgctaa tgtggcagca gccacaccag ccattaaaaa gccaccctca ggtttcaagg     2100

gcaccatccc caagaggcca tggctctccg ctaccccatc gagtggtgct tcagctgcca     2160

ggcaggccgg accggcacct gcagcggcaa cggctgcctc caagaagttc cctggctccg     2220

ctgctttggt gggagccgta aggaagccag tggtaccttc tgttccaatg gcctcgccag     2280

ccccaggacg ccttggggct atgagtgctg caccatcgca gccaaattca caaattcggc     2340

aaaatatcag acgctcctta aaagagattt tgtggaaaag agtcaatgac agcgatgact     2400

taatcatgac agaaaacgaa gtaggaaaaa ttgccctcca tattgagaag gagatgttta     2460

acttgtttca agttacagat aatcgctaca agagtaaata tcgcagcatc atgttcaacc     2520

tgaaggaccc taaaaatcag ggactcttcc atcgtgttct gcgtgaggaa atctctttgg     2580

cgaaacttgt gagactgaag ccagaagaac ttgtatctaa agagctttcc acgtggaaag     2640

agaggccagc gagatctgtg atggagtcca gaactaaact gcacaatgaa agcaagaaga     2700

cggcccccag gcaggaggcc atccccgatc tggaggactc tccgccagtg tcggattcag     2760

aggaacagca agagtcagca cgtgctgtcc ctgagaagag cacagcgccg cttctcgacg     2820

tcttcagcag catgttgaaa gacaccacca gtcagcaccg cgcacacctc ttcgatctca     2880

actgtaaaat ttgcacaggc caggttccct ccgcagaaga tgagccagct ccgaaaaaac     2940

aaaaattgtc agcttctgtt aagaaagaag acttaaaatc aaagcatgac agctctgcac     3000

ctgacccagc tccggattca gctgatgagg tgatgccgga ggctgtgcct gaagttgcct     3060

ctgagccagg cctagaaagt gcttctcatc caaatgtgga cagaacgtat ttccctgggc     3120

ctccaggaga tggccatccc gagccctccc cgctggaaga cctgtccccc tgcccagcct     3180

cctgtgggag cggggtggtc accaccgtca cagtgtccgg ccgggacccc aggaccgctc     3240

caagcagttc atgcacagcc gtggcctccg cagcatcccg cccagacagc acccacatgg     3300

tggaagccag acaggatgtg ccgaagcctg tcttgacttc tgtgatggtg cccaagtcca     3360

tactagctaa gccatcctca tctcctgacc caagatacct gtcagttcct ccgtcaccaa     3420

atatcagcac ttcagaatca cgttcccctc cagagggaga cacgaccctc tttttgtctc     3480

gactcagcac catttggaaa ggatttatta acatgcagag tgtggcaaaa tttgtcacta     3540

aggcgtatcc tgtctctggg tgttttgatt acctcagtga ggatttgcct gacacaattc     3600

acattggtgg gaggatcgca ccgaagacag tttgggatta tgttggcaaa ctcaagtctt     3660

ctgtgtctaa ggagctctgt ctgatccgct tccaccccgc cacagaggaa gaggaggtcg     3720

cctatatctc tctctactcc tatttcagca gccgtggccg ctttggtgtt gtagctaata     3780

acaacaggca cgtcaaggac ctctacctga tcccgctgag cgcccaggac cctgttccat     3840

ccaaactctt gccctttgag ggaccaggta agcgccggct ttctgggtgg aggtgaggcc     3900

cacctgcacc tgcacccctc ctcccactga catgccctgc tgagtcctga ccagcccagg     3960

gctctctggg agcaggagtt aggagcacag acgcagcggt tagcaatagg attcatcttt     4020

gagggcgtag gactgtggca cgagaagtac ccctgattca cagcataaat tgtcttagga     4080

gagtttttta gagagggaaa aacccacagc ctgcaaccag ctcatcttgg cctcaggtca     4140

gagaagactc agtgcccaga agcccaaggc tcagccagaa agggaggtga cactcccagc     4200

ggccctgctc tttcctctag acagactcgg gagccagcac acaccgggaa gtggctccat     4260

cagggatcac ttctctaaca gggatggatt tccaggagac ttaacaataa tgacatagaa     4320

aactatttct agaaataatt attttaaaat ctgcagctca aattgtaata ggttcattca     4380

tctttggcaa gctattttgt gtttgcacgt tccttggaaa gtactgtatt taaacgatta     4440

tttacaaata gcctaaaata catctttgtc aagggttgag ggtgattcca ggggccacgt     4500

gctctgttag tgaccagctc tttcatagcc ccttagaaga agctgatgtg acttcagtta     4560

ggggttagta tctgatgccc aactgaagtg tctccgtggc catgcagtcc ccagaggatt     4620

ggtgttctct caaagcgggt gtgtggatca cacagtgtcc tctgaagtgc ttcgtcataa     4680

aggcaggtgc tgtctggacc ctgtgcctca gtgccctctg tccctgtcac caggcctcgg     4740

cgggtgttcc tgccatagct gtgcagggtg ttcccaccca cacccctcat gccgcaccct     4800

agctagctgg ggtcctgtag gggccactcc acatcttggg cgggacttct gtcgccccag     4860

gcacagccca cgttcctact ggagcccatt cttcacagct ggagtgggct cagcctatgc     4920

ctgtgttgtg gaattatatg tccataaagg gattggttgg tatcagtaat ttcagggtta     4980

aatatttgct ggcgtggtgc attaaattat tttagtgcca gataaatttt taaaagcaaa     5040

gtgctttagt gtgtcccctc aaatcctact tgggataaag agatgccacc taatgggtgg     5100

cagaaaggac cctggtagag gttcttggtg ttgcttgtga agagctctgg ccagctccac     5160

gtgaccaggg agaggaaaag cccggccctc ctggaggtga agaccgagaa gctggcctct     5220

ccgcacctgt gaagacccac tggtcagttg caagtgcgac agtgtgtgca ctcagtgcag     5280

acactgcagc acctcagcac ctccctaccg gggtggaaag agcacttttt ctttacagaa     5340

acatgattct tagatagcga gcctcccctt tttaaaacaa ttgaggcgat atttcatcct     5400

ttcttgagct tctctccctg ctcatctcca aacttggagc tgtcaggtga gcacggttgt     5460

agggtgttga gcgagccccg gcgcatgccg ggcaccgggt tccccacact gggcagtgac     5520

ggggcccagg gaggccacca gaggagcggc gcctccattc tccccacagc aagggctggc     5580

tgtgcaggtg cagccccggg gcagagggaa aggacaggtc tcccagcacc tcccggatgg     5640

caccgggaca aggagggctg ggctggggtc actcaccttg tctgctgagt gcgatggcac     5700

caaccaccca cactgtcagc tccgcgacca gctgggggaa cgtcacactc gcccaccaag     5760

gcacttgctg aggccacgac gccgcctgac ggggacacac aaaagcccca gggactttga     5820

tccacgataa agagcagagg cgtctgggta aagtaacaca gggcaaggga ctttagaaaa     5880

gtaacagcta gtgaaacctt tccatacact tcagaaatgt tttaacttaa gacttcagta     5940

taatgttaac ttctcctgat gtccttgttg acatgaatgc gtgtgcgtga aatctcacac     6000

acttccatgg tcactaaaca gccttcaccc cgggccaggc catcgggtac tcggcccgct     6060

tcacgtactg attacttgac ttggcgtttt ctagatataa acatgtacat gtgtgtcctg     6120

gctttgtggt gtaaatgtgt agtgcgtgtg catgtgcgcg cgtgtgtgtg tgtaaggcta     6180

ggtcctggca tgtttcccct gtctcagcgg accctgtcct cacggagata gcccagaagc     6240

ccttggacag cacaggccac acctgagggt gctgatggtg gtgactccac agagctgtgg     6300

tcaggggtga gcgtgtgctg cgcagcttgg agtcacgccc ccagaagtgc tgggtgaggg     6360

tctgcaggac ccagctccat tccacagcct cagttctctg cggcacatgc agcacaggcc     6420

tgaaggagac ctggcgcccc agccttgagc tgcccgtctg catcagggca ctgatgtggg     6480

agcatcttcc cctggggatg ttaaggagaa ggtcctgttg ggggtagaga ttcacgcaga     6540

aaagagtgac tgactcgtcc atgtgcctca gtttatacca cacaattgca ggtgtccatg     6600

cctcccacac atggggacct agtgggtttt gacagcgtgg tgtccagtcc tagccccctc     6660

agtgcttgct gttcacactt aagcaagtga aggcctgaag gtgcccagct gtgccctcag     6720

gggaaactta agtcacccgc cctgtcagca cttggccctt gtcgggcagt gagagtggag     6780

ctgcccccgc agcaccctca ggagccatgc agttcacagc agtagctgga tctccctgag     6840

gacatttgtc cttgcatatc ttaatgattt gtccacagaa acaccgggtt gtcttcctct     6900

gcccctctgc cccgcagtgg gggcactctc tgtaactcag catcacggtg gggggcagct     6960

gggaggcctg gttccaggtg accttctcca cctagatgtt caccccactc agttccagct     7020

ttaccaacag ggccccccgc agggacttgg ggtcgcagag tcccggcctg tctcagggcc     7080

ttgttcatgg aagggagatg agtcaggttg aaagctcatc gtgtagggtt ctgtgcaggg     7140

cccttacagg actggaccgc agccaagatg cctgcctgtt aaccatgccc agcccccgtc     7200

atttccgcgt gaagccgcag gcctcggagc cttggtctga aatgcctgtg gagtaacctc     7260

ggtccataaa catgggtgca cagtctgttc tccccaagta cagggcagga ggaaacaccg     7320

ccctctgtag ctgctcgaat ggaaagggct cttttctctg aggtctttat acattagaaa     7380

gctcttctgg gaagaatgtt tgaatccata gtgtctttct gtattcactt ttaattgctt     7440

tctaaattag ctgagaaatt ctgacttgaa atattgtcag gtaagcattt cttcagtttt     7500

catgtgtgta tgtaacagta gctttgcatg gaaattgtaa tcagagtcaa atacagtatt     7560

gaatggaatg tactgccttc tcctcctaaa tcaataaaca tctttcatgg                7610


<210> 2380
<211> 7551
<212> DNA
<213> Homo sapiens

<400> 2380
ctcggtggcc gtccgcccac tccgcggcgt tcggggaaat ggctgcgaga ccctagaggc       60

ctgcggagct tactccacgg gaacagcctc tagataatct gagttgttga aaatacgaag      120

cctgttactc gtgaacagtg gctgacaaca gtgttgttgt gagcctggct gtctgcttgg      180

acccagaggt ttcgtctgcc agggtttttg gttgtattta ggatttcagg gaaaagtgtc      240

caagctttca gtgttggagc aggtatggac gacaaaggcg acccgagcaa tgaggaggca      300

cctaaggcca tcaaacccac cagcaaagag ttcaggaaaa catggggttt tcgaaggacc      360

actatcgcca agcgagaggg cgcaggggac gcggaggctg acccactgga gccgccaccc      420

ccacagcagc agctgggcct gtccctgcgg cgcagtggga ggcagcccaa gcgcactgag      480

cgcgtggagc agttcctgac cattgcgcgg cgccgcggca ggaggagcat gcctgtctcc      540

ctggaggatt ctggtgagcc cacgtcctgc cccgccacag acgccgagac agcctccgag      600

ggcagcgtgg aaagcgcttc tgagaccaga agcggccccc agtctgcttc cacagctgtg      660

aaggaacgac cagcctcttc tgaaaaggtg aaaggagggg atgaccacga tgacacctcc      720

gatagtgaca gcgatggcct gaccttgaaa gagcttcaga atcgccttcg caggaagcgg      780

gaacaggagc ccactgagag gcccctgaaa gggatccaga gtcgcctgcg gaagaagcgc      840

cgggaggagg gtcccgccga gactgtgggc tccgaggcca gtgacactgt ggagggcgtc      900

ctgcccagta agcaggagcc cgagaacgat cagggggttg tgtcccaggc tgggaaagat      960

gacagagaga gtaagttgga gggaaaggcg gctcaggaca tcaaagatga ggagcctgga     1020

gacttgggcc gaccgaagcc tgaatgtgag ggttacgacc ccaacgccct gtattgcatt     1080

tgccgccagc ctcacaacaa caggtttatg atttgctgtg accgctgtga agaatggttt     1140

catggcgatt gtgtgggcat ttctgaggct cgagggaggc ttttggaaag gaatggggaa     1200

gactatatct gcccaaactg caccattctg caagtgcagg atgagactca ttcagaaacg     1260

gcagatcagc aggaagctaa atggagacct ggagatgctg atggcaccga ttgtacaagt     1320

ataggaacaa tagagcagaa gtctagcgaa gaccaaggga taaagggtag aattgagaaa     1380

gctgcaaatc caagtggcaa gaagaaactc aagatcttcc agcctgtgat agaggcgcct     1440

ggtgcctcaa aatgtattgg ccccgggtgc tgtcacgtgg cgcagcccga ctcggtgtac     1500

tgcagtaatg actgtatcct caaacacgcc gcagcgacaa tgaagtttct aagctcaggt     1560

aaagaacaga agccaaagcc taaagaaaag atgaagatga agccagagaa gcccagtctt     1620

ccgaaatgcg gtgctcaggc aggtattaaa atctcttctg tgcacaagag accagctcca     1680

gaaaaaaaag agaccacagt gaagaaggca gtggtggtcc ctgcgcggag tgaagcactc     1740

gggaaggaag cagcttgtga gagcagcacg ccgtcgtggg cgagcgatca caattacaat     1800

gcagtaaagc cagaaaagac tgctgctccc tcgccgtcac tgttgtataa atccacgaag     1860

gaagacagga ggtccgagga gaaagcggca gccatggcag cctcaaagaa aacagcccct     1920

ccaggctccg cggtgggcaa gcagcctgca cctagaaacc tcgtgccaaa gaagtcttct     1980

tttgctaatg tggcagcagc cacaccagcc attaaaaagc caccctcagg tttcaagggc     2040

accatcccca agaggccatg gctctccgct accccatcga gtggtgcttc agctgccagg     2100

caggccggac cggcacctgc agcggcaacg gctgcctcca agaagttccc tggctccgct     2160

gctttggtgg gagccgtaag gaagccagtg gtaccttctg ttccaatggc ctcgccagcc     2220

ccaggacgcc ttggggctat gagtgctgca ccatcgcagc caaattcaca aattcggcaa     2280

aatatcagac gctccttaaa agagattttg tggaaaagag tcaatgacag cgatgactta     2340

atcatgacag aaaacgaagt aggaaaaatt gccctccata ttgagaagga gatgtttaac     2400

ttgtttcaag ttacagataa tcgctacaag agtaaatatc gcagcatcat gttcaacctg     2460

aaggacccta aaaatcaggg actcttccat cgtgttctgc gtgaggaaat ctctttggcg     2520

aaacttgtga gactgaagcc agaagaactt gtatctaaag agctttccac gtggaaagag     2580

aggccagcga gatctgtgat ggagtccaga actaaactgc acaatgaaag caagaagacg     2640

gcccccaggc aggaggccat ccccgatctg gaggactctc cgccagtgtc ggattcagag     2700

gaacagcaag agtcagcacg tgctgtccct gagaagagca cagcgccgct tctcgacgtc     2760

ttcagcagca tgttgaaaga caccaccagt cagcaccgcg cacacctctt cgatctcaac     2820

tgtaaaattt gcacaggcca ggttccctcc gcagaagatg agccagctcc gaaaaaacaa     2880

aaattgtcag cttctgttaa gaaagaagac ttaaaatcaa agcatgacag ctctgcacct     2940

gacccagctc cggattcagc tgatgaggtg atgccggagg ctgtgcctga agttgcctct     3000

gagccaggcc tagaaagtgc ttctcatcca aatgtggaca gaacgtattt ccctgggcct     3060

ccaggagatg gccatcccga gccctccccg ctggaagacc tgtccccctg cccagcctcc     3120

tgtgggagcg gggtggtcac caccgtcaca gtgtccggcc gggaccccag gaccgctcca     3180

agcagttcat gcacagccgt ggcctccgca gcatcccgcc cagacagcac ccacatggtg     3240

gaagccagac aggatgtgcc gaagcctgtc ttgacttctg tgatggtgcc caagtccata     3300

ctagctaagc catcctcatc tcctgaccca agatacctgt cagttcctcc gtcaccaaat     3360

atcagcactt cagaatcacg ttcccctcca gagggagaca cgaccctctt tttgtctcga     3420

ctcagcacca tttggaaagg atttattaac atgcagagtg tggcaaaatt tgtcactaag     3480

gcgtatcctg tctctgggtg ttttgattac ctcagtgagg atttgcctga cacaattcac     3540

attggtggga ggatcgcacc gaagacagtt tgggattatg ttggcaaact caagtcttct     3600

gtgtctaagg agctctgtct gatccgcttc caccccgcca cagaggaaga ggaggtcgcc     3660

tatatctctc tctactccta tttcagcagc cgtggccgct ttggtgttgt agctaataac     3720

aacaggcacg tcaaggacct ctacctgatc ccgctgagcg cccaggaccc tgttccatcc     3780

aaactcttgc cctttgaggg accaggtaag cgccggcttt ctgggtggag gtgaggccca     3840

cctgcacctg cacccctcct cccactgaca tgccctgctg agtcctgacc agcccagggc     3900

tctctgggag caggagttag gagcacagac gcagcggtta gcaataggat tcatctttga     3960

gggcgtagga ctgtggcacg agaagtaccc ctgattcaca gcataaattg tcttaggaga     4020

gttttttaga gagggaaaaa cccacagcct gcaaccagct catcttggcc tcaggtcaga     4080

gaagactcag tgcccagaag cccaaggctc agccagaaag ggaggtgaca ctcccagcgg     4140

ccctgctctt tcctctagac agactcggga gccagcacac accgggaagt ggctccatca     4200

gggatcactt ctctaacagg gatggatttc caggagactt aacaataatg acatagaaaa     4260

ctatttctag aaataattat tttaaaatct gcagctcaaa ttgtaatagg ttcattcatc     4320

tttggcaagc tattttgtgt ttgcacgttc cttggaaagt actgtattta aacgattatt     4380

tacaaatagc ctaaaataca tctttgtcaa gggttgaggg tgattccagg ggccacgtgc     4440

tctgttagtg accagctctt tcatagcccc ttagaagaag ctgatgtgac ttcagttagg     4500

ggttagtatc tgatgcccaa ctgaagtgtc tccgtggcca tgcagtcccc agaggattgg     4560

tgttctctca aagcgggtgt gtggatcaca cagtgtcctc tgaagtgctt cgtcataaag     4620

gcaggtgctg tctggaccct gtgcctcagt gccctctgtc cctgtcacca ggcctcggcg     4680

ggtgttcctg ccatagctgt gcagggtgtt cccacccaca cccctcatgc cgcaccctag     4740

ctagctgggg tcctgtaggg gccactccac atcttgggcg ggacttctgt cgccccaggc     4800

acagcccacg ttcctactgg agcccattct tcacagctgg agtgggctca gcctatgcct     4860

gtgttgtgga attatatgtc cataaaggga ttggttggta tcagtaattt cagggttaaa     4920

tatttgctgg cgtggtgcat taaattattt tagtgccaga taaattttta aaagcaaagt     4980

gctttagtgt gtcccctcaa atcctacttg ggataaagag atgccaccta atgggtggca     5040

gaaaggaccc tggtagaggt tcttggtgtt gcttgtgaag agctctggcc agctccacgt     5100

gaccagggag aggaaaagcc cggccctcct ggaggtgaag accgagaagc tggcctctcc     5160

gcacctgtga agacccactg gtcagttgca agtgcgacag tgtgtgcact cagtgcagac     5220

actgcagcac ctcagcacct ccctaccggg gtggaaagag cactttttct ttacagaaac     5280

atgattctta gatagcgagc ctcccctttt taaaacaatt gaggcgatat ttcatccttt     5340

cttgagcttc tctccctgct catctccaaa cttggagctg tcaggtgagc acggttgtag     5400

ggtgttgagc gagccccggc gcatgccggg caccgggttc cccacactgg gcagtgacgg     5460

ggcccaggga ggccaccaga ggagcggcgc ctccattctc cccacagcaa gggctggctg     5520

tgcaggtgca gccccggggc agagggaaag gacaggtctc ccagcacctc ccggatggca     5580

ccgggacaag gagggctggg ctggggtcac tcaccttgtc tgctgagtgc gatggcacca     5640

accacccaca ctgtcagctc cgcgaccagc tgggggaacg tcacactcgc ccaccaaggc     5700

acttgctgag gccacgacgc cgcctgacgg ggacacacaa aagccccagg gactttgatc     5760

cacgataaag agcagaggcg tctgggtaaa gtaacacagg gcaagggact ttagaaaagt     5820

aacagctagt gaaacctttc catacacttc agaaatgttt taacttaaga cttcagtata     5880

atgttaactt ctcctgatgt ccttgttgac atgaatgcgt gtgcgtgaaa tctcacacac     5940

ttccatggtc actaaacagc cttcaccccg ggccaggcca tcgggtactc ggcccgcttc     6000

acgtactgat tacttgactt ggcgttttct agatataaac atgtacatgt gtgtcctggc     6060

tttgtggtgt aaatgtgtag tgcgtgtgca tgtgcgcgcg tgtgtgtgtg taaggctagg     6120

tcctggcatg tttcccctgt ctcagcggac cctgtcctca cggagatagc ccagaagccc     6180

ttggacagca caggccacac ctgagggtgc tgatggtggt gactccacag agctgtggtc     6240

aggggtgagc gtgtgctgcg cagcttggag tcacgccccc agaagtgctg ggtgagggtc     6300

tgcaggaccc agctccattc cacagcctca gttctctgcg gcacatgcag cacaggcctg     6360

aaggagacct ggcgccccag ccttgagctg cccgtctgca tcagggcact gatgtgggag     6420

catcttcccc tggggatgtt aaggagaagg tcctgttggg ggtagagatt cacgcagaaa     6480

agagtgactg actcgtccat gtgcctcagt ttataccaca caattgcagg tgtccatgcc     6540

tcccacacat ggggacctag tgggttttga cagcgtggtg tccagtccta gccccctcag     6600

tgcttgctgt tcacacttaa gcaagtgaag gcctgaaggt gcccagctgt gccctcaggg     6660

gaaacttaag tcacccgccc tgtcagcact tggcccttgt cgggcagtga gagtggagct     6720

gcccccgcag caccctcagg agccatgcag ttcacagcag tagctggatc tccctgagga     6780

catttgtcct tgcatatctt aatgatttgt ccacagaaac accgggttgt cttcctctgc     6840

ccctctgccc cgcagtgggg gcactctctg taactcagca tcacggtggg gggcagctgg     6900

gaggcctggt tccaggtgac cttctccacc tagatgttca ccccactcag ttccagcttt     6960

accaacaggg ccccccgcag ggacttgggg tcgcagagtc ccggcctgtc tcagggcctt     7020

gttcatggaa gggagatgag tcaggttgaa agctcatcgt gtagggttct gtgcagggcc     7080

cttacaggac tggaccgcag ccaagatgcc tgcctgttaa ccatgcccag cccccgtcat     7140

ttccgcgtga agccgcaggc ctcggagcct tggtctgaaa tgcctgtgga gtaacctcgg     7200

tccataaaca tgggtgcaca gtctgttctc cccaagtaca gggcaggagg aaacaccgcc     7260

ctctgtagct gctcgaatgg aaagggctct tttctctgag gtctttatac attagaaagc     7320

tcttctggga agaatgtttg aatccatagt gtctttctgt attcactttt aattgctttc     7380

taaattagct gagaaattct gacttgaaat attgtcaggt aagcatttct tcagttttca     7440

tgtgtgtatg taacagtagc tttgcatgga aattgtaatc agagtcaaat acagtattga     7500

atggaatgta ctgccttctc ctcctaaatc aataaacatc tttcatggaa a              7551


<210> 2381
<211> 8477
<212> DNA
<213> Homo sapiens

<400> 2381
ctcggtggcc gtccgcccac tccgcggcgt tcggggaaat ggctgcgaga ccctagaggc       60

ctgcggagct tactccacgg gaacagcctc tagataatct gagttgttga aaatacgaag      120

cctgttactc gtgaacagtg gctgacaaca gtgttgttgt gagcctggct gtctgcttgg      180

acccagaggt ttcgtctgcc agggtttttg gttgtattta ggatttcagg gaaaagtgtc      240

caagctttca gtgttggagc aggtatggac gacaaaggcg acccgagcaa tgaggaggca      300

cctaaggcca tcaaacccac cagcaaagag ttcaggaaaa catggggttt tcgaaggacc      360

actatcgcca agcgagaggg cgcaggggac gcggaggctg acccactgga gccgccaccc      420

ccacagcagc agctgggcct gtccctgcgg cgcagtggga ggcagcccaa gcgcactgag      480

cgcgtggagc agttcctgac cattgcgcgg cgccgcggca ggaggagcat gcctgtctcc      540

ctggaggatt ctggtgagcc cacgtcctgc cccgccacag acgccgagac agcctccgag      600

ggcagcgtgg aaagcgcttc tgagaccaga agcggccccc agtctgcttc cacagctgtg      660

aaggaacgac cagcctcttc tgaaaaggtg aaaggagggg atgaccacga tgacacctcc      720

gatagtgaca gcgatggcct gaccttgaaa gagcttcaga atcgccttcg caggaagcgg      780

gaacaggagc ccactgagag gcccctgaaa gggatccaga gtcgcctgcg gaagaagcgc      840

cgggaggagg gtcccgccga gactgtgggc tccgaggcca gtgacactgt ggagggcgtc      900

ctgcccagta agcaggagcc cgagaacgat cagggggttg tgtcccaggc tgggaaagat      960

gacagagaga gtaagttgga gggaaaggcg gctcaggaca tcaaagatga ggagcctgga     1020

gacttgggcc gaccgaagcc tgaatgtgag ggttacgacc ccaacgccct gtattgcatt     1080

tgccgccagc ctcacaacaa caggtttatg atttgctgtg accgctgtga agaatggttt     1140

catggcgatt gtgtgggcat ttctgaggct cgagggaggc ttttggaaag gaatggggaa     1200

gactatatct gcccaaactg caccattctg caagtgcagg atgagactca ttcagaaacg     1260

gcagatcagc aggaagctaa atggagacct ggagatgctg atggcaccga ttgtacaagt     1320

ataggaacaa tagagcagaa gtctagcgaa gaccaaggga taaagggtag aattgagaaa     1380

gctgcaaatc caagtggcaa gaagaaactc aagatcttcc agcctgtgat agaggcgcct     1440

ggtgcctcaa aatgtattgg ccccgggtgc tgtcacgtgg cgcagcccga ctcggtgtac     1500

tgcagtaatg actgtatcct caaacacgcc gcagcgacaa tgaagtttct aagctcaggt     1560

aaagaacaga agccaaagcc taaagaaaag atgaagatga agccagagaa gcccagtctt     1620

ccgaaatgcg gtgctcaggc aggtattaaa atctcttctg tgcacaagag accagctcca     1680

gaaaaaaaag agaccacagt gaagaaggca gtggtggtcc ctgcgcggag tgaagcactc     1740

gggaaggaag cagcttgtga gagcagcacg ccgtcgtggg cgagcgatca caattacaat     1800

gcagtaaagc cagaaaagac tgctgctccc tcgccgtcac tgttgtataa atccacgaag     1860

gaagacagga ggtccgagga gaaagcggca gccatggcag cctcaaagaa aacagcccct     1920

ccaggctccg cggtgggcaa gcagcctgca cctagaaacc tcgtgccaaa gaagtcttct     1980

tttgctaatg tggcagcagc cacaccagcc attaaaaagc caccctcagg tttcaagggc     2040

accatcccca agaggccatg gctctccgct accccatcga gtggtgcttc agctgccagg     2100

caggccggac cggcacctgc agcggcaacg gctgcctcca agaagttccc tggctccgct     2160

gctttggtgg gagccgtaag gaagccagtg gtaccttctg ttccaatggc ctcgccagcc     2220

ccaggacgcc ttggggctat gagtgctgca ccatcgcagc caaattcaca aattcggcaa     2280

aatatcagac gctccttaaa agagattttg tggaaaagag tcaatgacag cgatgactta     2340

atcatgacag aaaacgaagt aggaaaaatt gccctccata ttgagaagga gatgtttaac     2400

ttgtttcaag ttacagataa tcgctacaag agtaaatatc gcagcatcat gttcaacctg     2460

aaggacccta aaaatcaggg actcttccat cgtgttctgc gtgaggaaat ctctttggcg     2520

aaacttgtga gactgaagcc agaagaactt gtatctaaag agctttccac gtggaaagag     2580

aggccagcga gatctgtgat ggagtccaga actaaactgc acaatgaaag caagaagacg     2640

gcccccaggc aggaggccat ccccgatctg gaggactctc cgccagtgtc ggattcagag     2700

gaacagcaag agtcagcacg tgctgtccct gagaagagca cagcgccgct tctcgacgtc     2760

ttcagcagca tgttgaaaga caccaccagt cagcaccgcg cacacctctt cgatctcaac     2820

tgtaaaattt gcacaggcca ggttccctcc gcagaagatg agccagctcc gaaaaaacaa     2880

aaattgtcag cttctgttaa gaaagaagac ttaaaatcaa agcatgacag ctctgcacct     2940

gacccagctc cggattcagc tgatgaggtg atgccggagg ctgtgcctga agttgcctct     3000

gagccaggcc tagaaagtgc ttctcatcca aatgtggaca gaacgtattt ccctgggcct     3060

ccaggagatg gccatcccga gccctccccg ctggaagacc tgtccccctg cccagcctcc     3120

tgtgggagcg gggtggtcac caccgtcaca gtgtccggcc gggaccccag gaccgctcca     3180

agcagttcat gcacagccgt ggcctccgca gcatcccgcc cagacagcac ccacatggtg     3240

gaagccagac aggatgtgcc gaagcctgtc ttgacttctg tgatggtgcc caagtccata     3300

ctagctaagc catcctcatc tcctgaccca agatacctgt cagttcctcc gtcaccaaat     3360

atcagcactt cagaatcacg ttcccctcca gagggagaca cgaccctctt tttgtctcga     3420

ctcagcacca tttggaaagg atttattaac atgcagagtg tggcaaaatt tgtcactaag     3480

gcgtatcctg tctctgggtg ttttgattac ctcagtgagg atttgcctga cacaattcac     3540

attggtggga ggatcgcacc gaagacagtt tgggattatg ttggcaaact caagtcttct     3600

gtgtctaagg agctctgtct gatccgcttc caccccgcca cagaggaaga ggaggtcgcc     3660

tatatctctc tctactccta tttcagcagc cgtggccgct ttggtgttgt agctaataac     3720

aacaggcacg tcaaggacct ctacctgatc ccgctgagcg cccaggaccc tgttccatcc     3780

aaactcttgc cctttgaggg accaggtctt gagtcaccac gtccgaatat aattcttggg     3840

ttagtaatct gccaaaaaat caaacgtccc gcaaacagtg gagagttaga caagatggac     3900

gaaaagcgga cccgacttca accggaagaa gcggacgttc cggcctatcc aaaagtagcc     3960

acagtcccgc agtcggaaaa gaagccctcc aagtatccac tctgctctgc agacgcggct     4020

gtcagcacca cacctcctgg gtcgccgccg cctccgcccc ctcttccaga accaccggtg     4080

ctaaaagtgc tgtcatccct caaacctgca gcccccagcc cagccacagc agccacaaca     4140

gcagcggcag cctccacggc agcttcctcc accgcttcgt ctgcttccaa aacagcatca     4200

ccgctggagc acatcctgca gactctcttt ggaaagaaga aatcattcga cccgtccgcc     4260

agagagcctc ccgggtccac cgcaggtctc ccccaggagc ccaaaaccac agcagaggac     4320

ggggtgccgg cacctccgtt gttagatccg atcgtccagc agttcggtca gttctcaaaa     4380

gataaggctc tagaggaaga ggaggacgac aggccatacg accctgagga ggagtacgac     4440

ccggagaggg ccttcgacac tcagcttgtg gagcgagggc ggcgccacga ggtggaaagg     4500

gctcctgaag cagctgcagc cgagcgggaa gaggtggcct atgaccccga ggatgagacc     4560

atcttagaag aagcgaaagt gactgttgat gacctgccca acaggatgtg tgccgacgtg     4620

agaaggaact ccgtggagag gcctgccgag ccggtggccg gggctgcgac gccctccctg     4680

gtggagcaac agaagatgct agaagagctg aacaaacaga tcgaggagca gaagagacag     4740

ctggaggagc aagaagaagc tctcaggcag cagagggccg ccgtcggggt ctccatggcc     4800

cacttctcgg tgtcggacgc cttgatgtct ccaccaccaa agtcgtcctt gcccaaggca     4860

gagctgttcc agcaagagca gcagtctgca gacaagcccg cctcactgcc ccccgccagc     4920

caggcgtcaa accacaggga cccccggcag gcgaggcgcc tggccactga gaccggtgag     4980

ggggaggggg agcctctctc caggctctcg gcacgtggtg cccagggtgc cctgcccgag     5040

agagatgctt ccaggggtgg cctcgtgggc caggcgccca tgccagtccc ggaggaaaaa     5100

gagccagcct cttccccctg ggcttcgggc gaaaagcccc cagcggggtc cgagcaggac     5160

ggctggaagg cagagcctgg ggagggcacc cgccccgcca cggttggaga cagctcggcc     5220

aggcctgccc ggagggtgct gctgcccaca ccgccttgcg gcgccctgca gcccggcttc     5280

ccgctgcagc acgacggtga gagggaccct ttcacctgcc cggggttcgc gtcgcaggac     5340

aaggctctcg gctcagccca gtatgaggac ccaagaaatc ttcattctgc tggaaggagc     5400

agcagccctg caggtgaaac agagggggac agagagccac aggccagacc cggcgagggc     5460

accgccccgc tccccccacc aggacagaaa gtggggggct ctcagccccc gtttcagggt     5520

cagcgggaac ctggacctca tgctttgggg atgtcagggc ttcacggccc caatttcccg     5580

ggaccaaggg ggccagcccc tccgtttcca gaagagaata tcgcttctaa cgatgggcca     5640

cgagggcctc cgccagccag attcggagcc cagaaggggc ccatcccttc cttattctcg     5700

gggcaacatg ggccacctcc ttatggggac agcagaggcc cctcaccctc ttaccttggt     5760

ggaccacgag gagtggcacc atcccaattt gaagaacgca aggatcccca tggggagaag     5820

agggagttcc aggacgcccc gtataacgag gtgacgggcg cccccgccca gtttgaaggg     5880

acagagcaag ccccatttct gggaagcaga ggcggcgcgc ctttccagtt cggaggccag     5940

agaaggccac tgctgtctca gctgaaaggc ccccgaggcg gcccccctcc ctctcagttt     6000

ggaggtcaga gaggaccacc ccctggtcat ttcgtgggcc caagagggcc ccatcctagt     6060

cagtttgaaa ctgcccgggg ccctcatccc aaccagtttg aaggacccag aggccaagcg     6120

cctaacttta tgccaggtcc caggggcatt cagcctcagc agttcgaaga ccagagggtc     6180

cattcaccac caagattcac aaaccaaagg gcgcctgcac ccctgcagtt tggtggacta     6240

cgggggtccg cacccttttc tgaaaaaaat gagcagaccc cttcgcgatt tcacttccag     6300

ggccaggccc cgcaggtgat gaagccgggc cccaggcccc tgctggagct tcccagccac     6360

cccccgcagc accggaagga ccgctgggag gaggccgggc cgccctccgc gctctcctcc     6420

agtgcgcccg gacagggccc cgaggccgac ggacagtggg catcggccga cttccgagag     6480

gggaaaggcc acgaatacag aaaccagact ttcgaaggga ggcagagaga gcggtttgac     6540

gtggggccca aagagaagcc gctggaggag cccgacgccc agggccgggc gtccgaggac     6600

aggaggagag agcgcgagcg cggccgaaac tggagccgag agcgggactg ggaccggccc     6660

cgggagtggg accgacaccg ggacaaggac tccagccggg actgggacag aaaccgggag     6720

aggagcgcca accgcgaccg agagcgcgag gccgaccggg gcaaggagtg ggaccgcagc     6780

cgggagcgga gcaggaaccg agagcgcgag cgagaccgga ggcgcgaccg ggaccggtcc     6840

cggagcagag agcgggaccg agacaaggcc agggacaggg agcggggccg cgaccgcaag     6900

gaccggagca agagcaaaga gagcgctcgg gacccgaagc ccgaggcctc gagggcctcc     6960

gacgctggca ccgcctcgca ggcctagacg ccccggccgg gcagagaccc tttttaaagc     7020

cacgttcgta agatgcgttg aacaaatagc ttttgaaata gccacgatct tagattcagg     7080

atagaatatt ctggacttaa acattactgt aattttgtgt aaatggtttc ttacaagatt     7140

tcacatcttt acaattctga tgctttttta aaaaaactaa actttaatat ttccatttaa     7200

aattaaaaga aatgggaaat tgcctacgga gcatattgct tttcagatca tagttatctt     7260

ttccaataac tttattgtaa attttaaggg agtttcgttg gaccctagag ccataccttc     7320

actgacatct catccgtttg tgtttccaaa agctgctttt acaggtctta gccgccgccc     7380

cggaggccgg tgtgggcgtg acctgcaggc gtccaccctg cggctacggg agaagtctta     7440

gtagcttgta tctggagtct tgagaaacac aaaccttaca aatgcatctt tcttttgtca     7500

taaaattgga attacaattt tcaactggga aacagaaaca catttcttag cgtgctcaga     7560

ttttatatat caccttatca attttttcca aaacatgatt taaagcaaca tctgtcctag     7620

tataattgtt gcattttaaa taacaattta ttgaaaaatg ttaagtttta ccagcctaaa     7680

aaaagtaaca aaccaattaa gtgtactttg ggggcaggga ggagtccttg atttgaataa     7740

tcaggagttt tgttggtcca gtttcgcctt ctgagcagtt cttctgtatc ccgggaaaag     7800

tacgctcggc cccaaactgg tatttgtcag acgatacatg taaaagtttg tccttgaacg     7860

tggaacaaga cttgtgtaaa gtctgagacg ggaactagtg atcactagct caagaactgc     7920

aaatgagaca ggaagctgtt cactgtgaaa cagtctcttg cttgtcgtgt atttttcgag     7980

tacttctgaa gtgtgaagta aaaaaatctg gctaatttat ttgtacaaat acactttgat     8040

aattttttat attttcataa acttttacag atgtaaaatt aaagaacttc acttgttctt     8100

tggagtctgt tattccattg tacgtcacta cagatttttc actttatagc acagattttt     8160

taagttaaga aaacattgag aatgtatcag tttgagatgt ttggtgttga aagccaagtg     8220

tccataggtt aaattacatt aaagtaggtg tcacgttcca acatctagta cgatgagaag     8280

gttttgtttg tttaacatat aaagcaaatt tttctaattt aaatacacaa atgtaaaaat     8340

caagtgtgtt tctttagttt acttgataga gattcctgta cattgtattt tatattgcgg     8400

aggcttatat cactgtacat gagaacatgg aacgacctag gttttgttac tcgcagtaga     8460

ataaacagct acaggaa                                                    8477


<210> 2382
<211> 2369
<212> DNA
<213> Homo sapiens

<400> 2382
agacagagtc ttgctctgtt gcggaggctg gagtgcagtg atctcagctc actggaagct       60

ccgcctcctg ggttcaagcg attctcctat ctcaacctcc caagtgtgcc accacacctg      120

ccgaatgttt gtgtttttag tagggatggg gttcgccatg ttgggcaggc tggtctcaaa      180

ctcctgacct caagtgatct gcccgcctcg gcctcccaga gtgctgggat tataggcgtg      240

agccaccatg cctggacatg accctgtctc taaaacaatg taatgaactg cagctcattc      300

ttgtgtgcac ttttctgcac cccctttccc ttaacactta ctattgtctg gcatgctacg      360

tgttttcttg atctcattag cctctcccac cccaactgcc acactgcact atcagagggc      420

agcacttatc actgctgtag aacaaagtcc tgcactgagc cgatggccca gaaattttct      480

ttttatttat ttatttattt tttttttgag acagagtctt actctgtcgc tcaggctgga      540

gtgtagtggc gcgatctcag ctcactgcaa cctctgcctc ctggtttcaa gcaattctcc      600

ttcctcagcc tccagagtag ctgggattac acgcgcctgc caccgcgcct ggctaatttt      660

tgtattttta gtagagatgg ggtttcaacc atgttggcca ggctggtctc aaactcctga      720

cctcaggtga tcctgcccac ctaagcctcc caaaatgctg gtattacagg catgagccac      780

cgtgcccggc ctaaatattt aataaaataa tggacgatgg gtgccttcta ctgagctccc      840

ggtaattgtg agtgagtaga ggacttgccc tggggacatt cagtgacctg ctgggtgttg      900

ctgagctgtg aggaagttca ggtctggctg cagtggtgag gctgtgactc aatcaatcac      960

tgctgatgct cccaggacct gcaccagctt agtcctaggg gcaaggattt taactgtcca     1020

cctcagtttc ttcatttgta agatgcaaat aacagtcacc cctgcctcat gggatggagc     1080

tgtgtaatgc ccgcaacagt gcctgctgca tagaggggtt gctgccagct gcctctccct     1140

ccttgtctct tacctgcctg ctgcctgggt caggatgaag aggggccctt gtgttgcccc     1200

caccctggct gcctgctaag ggcccatgtg atctgcctgg cagaggagtt tcttcaggaa     1260

gaaccagggc agcttctgcc cctagagggc caatgccctt gctgtgagaa gtcactgctt     1320

tggggagacc tgatctggct gtgccagatg gacactgaga aagaagtaga agactcagaa     1380

ttagaagagg aacatggagc tgatccagga cacctcccgc ccgccactgg agtacgtgaa     1440

gggggtcccg ctcatcaagt actttgcaga ggcactgggg cccctgcaga gcttccaagc     1500

ccgacctgat gacctgctca tcaacaccta ccccaagtct ggcaccacct gggtgagcca     1560

gatactggac atgatctacc agggcggcga cctagagaag tgtaaccggg ctcccatcta     1620

cgtacgggtg cccttccttg aggtcaatga tccaggggaa ccctcagggc tggagactct     1680

gaaagacaca ccgcccccac ggctcatcaa gtcacacctg cccctggctc tgctccctca     1740

gactctgttg gatcagaagg tcaaggtggt ctatgttgcc cgaaacccaa aggacgtggc     1800

ggtctcctac taccatttcc accgtatgga aaaggcgcac cctgagcctg ggacctggga     1860

cagcttcctg gaaaagttca tggctggaga agtgtcctac gggtcctggt accagcacgt     1920

gcaggagtgg tgggagctga gccgcaccca ccctgttctc tacctcttct atgaagacat     1980

gaaggagaac cccaaaaggg agattcaaaa gatcctggag tttgtggggc gctccctgcc     2040

agaggagacc atggacttca tggttcagca cacgtcgttc aaggagatga agaagaaccc     2100

tatgaccaac tacaccaccg tcccccagga gctcatggac cacagcatct cccccttcat     2160

gaggaaaggc atggctgggg actggaagac caccttcacc gtggcgcaga atgagcgctt     2220

cgatgcggac tatgcggaga agatggcagg ctgcagcctc agcttccgct ctgagctgtg     2280

agaggggctc ctggagtcac tgcagaggga gtgtgcgaat ctaccctgac caatgggctc     2340

aagaataaag tatgattttt gagtcaggc                                       2369


<210> 2383
<211> 1851
<212> DNA
<213> Homo sapiens

<400> 2383
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc       60

ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct      120

gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actctcagaa      180

gaaagacaag ctgctctgca gccagcttca ggtagcggat ttcctgcaga acatcctggc      240

tcaggaggac actgctaagg gtctcgaccc cttggcttct gaagacacga gccgacagaa      300

ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga      360

ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaaacg      420

gacacaactc cgggaagcct ttgagcagct ccaggccaag aaacaaatgg ccatggagaa      480

acgcagagca gtccagaacc agtggcagct acaacaggag aagcatctgc agcatctggc      540

ggaggtttct gcagaggtga gggagcgtaa gacagggact cagcaggagc ttgacagggt      600

gtttcagaaa cttggaaacc tgaagcagca ggcagaacag gagcgggaca agctgcagag      660

gtatcagacc ttcctccagc ttctgtatac cctgcagggt aagctgttgt tccctgaggc      720

tgaggctgag gcagagaatc ttccagatga taaaccccag cagccgactc gaccccagga      780

gcagagtaca ggagacacca tggggagaga ccctggtgtg tccttcaagg ctgttggtct      840

acaacctgct ggagatgtaa atttgccatg acttcctgga ggacagcagc atggagaaag      900

atcctagaaa aggtcagacc caactcaggc cttggtgtcc ctggactgca agtgtggaag      960

gagggaaagc ctggtttacc tctctctgca tctgagctct gctacccatg gagcagatgg     1020

atggtgggaa caggaaagag cttatgttac acctcattcc catgcttagc ccacccagag     1080

ctaacccctg tcttcttccc caggcctctg acttccctca cctcccaacc atcattacag     1140

gaaagactgt gaactcctga gttcagcttg atttctgact acatcccagc aagctctggc     1200

atctgtggat taaaatccct ggatctctct cagttgtgta tttgttcatc ttcatatgct     1260

ggcaggaaca actattaata cagatactca gaagccaata acatgacagg agctgggact     1320

ggtttgaaca cagggtgtgc agatggggag ggggtactgg ccttgggcct cctatgatgc     1380

agacatggtg aatttaattc aaggaggagg agaatgtttt aggcaggtgg ttatatgtgg     1440

gaagataatt ttattcatgg atccaaatgt ttgttgagtc ctttctttgt gctaaggttc     1500

ttgcggtgaa ccagaattat aacagtgagc tcatctgact gttttaggat gtacagccta     1560

gtgttaacat tcttggtatc tttttgtgcc ttatctaaaa catttctcga tcactggttt     1620

cagatgttca tttattatat tcttttcaaa gattcagaga ttggcttttg tcatccacta     1680

ttgtatgttt tgtttcattg acctctagtg ataccttgat ctttcccact ttctgttttc     1740

ggattggaga agatgtacct tttttgtcaa ctcttacttt tatcagatga tcaactcacg     1800

tatttggatc tttatttgtt ttctcaaata aatatttaag gttatacatt t              1851


<210> 2384
<211> 1615
<212> DNA
<213> Homo sapiens

<400> 2384
atggggacag tcacagaaga tcttattaga cggaatgctg aacacaacga ctgtgtcatt       60

ttttccctgg aggaactctc gttgcatcag caagaaatag aaagactaga acacattgat      120

aaatggtgcc gggatttaaa aattctctat cttcaaaata atcttattgg gaaaattgaa      180

aatgttagca aactcaagaa acttgaatat ttgaatttag ctttaaacaa cattgaaaaa      240

atagaaaact tggaaggatg tgaagagctg gcaaaacttg acctgactgt gaatttcatt      300

ggagagctga gcagcattaa aaacttgcag cacaatatcc atctgaagga gctctttctc      360

atggggaacc catgtgcttc ctttgaccac tatagggagt tcgtggtagc aactcttcca      420

caattaaagt ggttggatgg taaagaaata gagccttcag aaaggattaa ggcattgcag      480

gactattcag taattgaacc acaaatcaga gagcaggaaa aagatcactg tcttaaacga      540

gccaaactca aggaagaggc tcagaggaaa caccaagaag aggataaaaa tgaagacaag      600

agaagtaacg caggctttga tggacgttgg tacacagaca tcaatgctac tctttcctct      660

ttagagagca aagaccacct acaggcacca gacacagagg aacacaacac aaagaaatta      720

gacaacagtg aagatgactt ggaattctgg aataagccct gtttgtttac tcctgaatca      780

agattggaaa ctcttagaca catggaaaaa caacggaaga aacaggaaaa attaagtgaa      840

aaaaagaaga aagtgaaacc acccaggact ttgatcactg aagatgggaa agccctaaat      900

gtgaatgagc ccaaaattga cttctctttg aaagataacg aaaagcagat catcctggac      960

cttgctgtct ataggtatat ggatacctct ttaatcgatg ttgatgtgca accaacttac     1020

gtgcgagtaa tgatcaaagg aaagccattt cagcttgtcc ttcctgcaga agtgaaaccc     1080

gatagtagtt ctgctaaaag atctcagaca acgggtcatt tggtcatctg catgcccaag     1140

gtaggagaag taatcacagg tggtcagcga gcattcaaat ctatgaaaac tacctcggac     1200

aggagcagag aacaaacaaa tacaagctat tctactggat tctagaggtg atgtttctga     1260

cagtcaggtc gtgggtaaga ccagtgatgg gcgtccgtcc tagaggcctc tgacattaag     1320

gcggggaaag caaagaagca agcacatgga gaaactagaa gtagacccta gcaagcactc     1380

attccctgat gtgactaaca tagttcaaga gaaaaaacac acacccagaa gacgacctga     1440

acccaaaatt ataccaagtg aggaagaccc aacctttgaa gacaaccctg aagtgcctcc     1500

gctgatttga aacatctggc tgcgttgcca ttggctgaga cccaccaggt ccagttttgg     1560

ttggtgtaga gaccatatgc atattattcc tgggataaac acagagttat ttgtc          1615


<210> 2385
<211> 2954
<212> DNA
<213> Homo sapiens

<400> 2385
cttcggagtc ggcggtggtc gtccagaccg agtgttcttt actttttgtt tggttgaggt       60

ttcacgctag aaggtggctc aggatgtctt catcacattt tgccagtcga cacaggaagg      120

atataagtac tgaaatgatt agaactaaaa ttgctcatag gaaatcactg tctcagaaag      180

aaaatagaca taaggaatac gaacgaaata gacactttgg tttgaaagat gtaaacattc      240

caaccttgga aggtagaatt cttgttgaat tagatgagac atctcaaggg cttgttccag      300

aaaagaccaa tgttaagcca agggcaatga aaactattct aggtgatcaa cgaaaacaga      360

tgctccaaaa atacaaagaa gaaaagcaac ttcaaaaatt gaaagagcag agagagaaag      420

ctaaacgagg aatatttaaa gtgggtcgtt atagacctga tatgccttgt tttcttttat      480

caaaccagaa tgctgtgaaa gctgagccaa aaaaggctat tccatcttct gtacggatta      540

caaggtcaaa ggccaaagac caaatggagc agactaagat tgataacgag agtgatgttc      600

gagcaatccg acctggtcca agacaaactt ctgaaaagaa agtgtcagac aaagagaaaa      660

aagttgtgca gcctgtaatg cccacgtcgt tgagaatgac tcgatcagct actcaagcag      720

caaagcaggt tcccagaaca gtctcatcta ccacagcaag aaagccagtc acaagagctg      780

ctaatgaaaa cgaaccagaa ggaaaggtgc caagtaaagg aagacctgcc aaaaatgtag      840

aaacaaaacc cgacaagggt atttcttgta aagtcgatag tgaagaaaat actttgaatt      900

cacaaactaa tgcaacaagt ggaatgaatc cagatggagt cttatcaaaa atggaaaact      960

tacctgagat aaatactgca aaaataaaag ggaagaattc ctttgcacct aaggatttta     1020

tgtttcagcc actggatggt ctgaagacct atcaagtaac acctatgact cccagaagtg     1080

ccaatgcttt tttgacaccc agttacacct ggactccttt aaaaacagaa gttgatgagt     1140

ctcaagcaac aaaagaaatt ttggcacaaa aatgtaaaac ttactctacc aagacaatac     1200

agcaagattc aaataaattg ccatgtcctt tgggtcctct aactgtttgg catgaagaac     1260

atgttttaaa taaaaatgaa gctactacta aaaatttaaa tggccttcca ataaaagaag     1320

tcccatcact tgaaagaaat gaaggtcgaa ttgctcagcc ccaccatggt gtgccatatt     1380

tcagaaatat cctccagtca gaaactgaga aattaacttc acattgcttc gagtgggaca     1440

ggaaacttga attggacatt ccagatgatg ctaaagatct tattcgcaca gcagttggtc     1500

aaacaagact ccttatgaag gaaaggttta aacagtttga aggactggtt gatgattgtg     1560

aatataaacg aggtataaag gagactacct gtacagatct ggatggattt tgggatatgg     1620

ttagttttca gatagaagat gtaatccaca aattcaacaa tctgatcaaa cttgaggaat     1680

ctgggtggca agtcaataat aatatgaatc ataatatgaa caaaaatgtc tttaggaaaa     1740

aagttgtctc aggtatagca agtaaaccaa aacaggatga tgctggaaga attgcagcga     1800

gaaatcgcct agctgccata aaaaatgcaa tgagagagag aattaggcag gaagaatgtg     1860

ctgaaacagc agtttctgtg ataccaaagg aagttgataa aatagtgttc gatgctggat     1920

ttttcagagt tgaaagtcct gttaaattat tctcaggact ttctgtctct tctgaaggcc     1980

cttctcaaag acttggaaca cctaagtctg tcaacaaagc tgtatctcag agtagaaatg     2040

agatgggcat tccacaacaa actacatcac cagaaaatgc cggtcctcag aatacgaaaa     2100

gtgaacatgt gaagaagact ttgtttttga gtattcctga aagcaggagc agcatagaag     2160

atgctcagtg tcctggatta ccagatttaa ttgaagaaaa tcatgttgta aataagacag     2220

acttgaaggt ggattgttta tccagtgaga gaatgagttt gcctcttctt gctggtggag     2280

tagcagatga tattaatact aacaaaaaag aaggaatttc agatgttgtg gaaggaatgg     2340

aactgaattc ttcaattaca tcacaggatg ttttgatgag tagccctgaa aaaaatacag     2400

cttcacaaaa tagcatctta gaagaagggg aaactaaaat ttctcagtca gaactatttg     2460

ataataaaag tctcactact gaatgccacc ttcttgattc agtgggatct tgctatgttg     2520

ctcgggctgg tcttgaagtc ctgggttcaa gtgatcctac cacctcagcc tcccgagtag     2580

ctgggactac agccaggtct aaactgcagt aatccattta ctcagctgga gaggagacat     2640

caagaacatg ccagacacat ttcttttggt ggtaacctga ttactttttc acctctacaa     2700

ccaggagaat tttgaattta aaaataaatc caaacatttt ccttcatatt atcaatgctt     2760

atatattcct tagactattg aaattttgga gaaaatgtat ttgtgttcac ttctatagca     2820

tataatgttt taatattctg tgttcatcaa agtgtatttt agatatactc tttctcaagg     2880

gaagtgggga tattttgtac attttcaaca cagaataaaa aatgtactgt gccttgcctc     2940

tcttgtttaa aagg                                                       2954


<210> 2386
<211> 1872
<212> DNA
<213> Homo sapiens

<400> 2386
atgctttgca gtccatcatt ttgcaaactt tgctggaaaa ggcagaggga aaatggacaa       60

agaaaatatg gtggccctcc acctggttgg gatgctgcac cccctgaaag gggctgtgaa      120

atttttattg gaaaacttcc ccgagacctt tttgaggatg agcttatacc attatgtgaa      180

aaaatcggta aaatttatga aatgagaatg atgatggatt ttaatggcaa caatagagga      240

tatgcatttg taacattttc aaataaagtg gaagccaaga atgcaatcaa gcaacttaat      300

aattatgaaa ttagaaatgg gcgcctctta ggggtttgtg ccagtgtgga caactgccga      360

ttatttgttg ggggcatccc aaaaaccaaa aagagagaag aaatcttatc ggagatgaaa      420

aaggttactg aaggtgttgt cgatgtcatc gtctacccaa gcgctgcaga taaaaccaaa      480

aaccgaggct ttgccttcgt ggagtatgag agtcatcgag cagctgccat ggcgaggagg      540

aaactgctac caggaagaat tcagttatgg ggacatggta ttgcagtaga ctgggcagag      600

ccagaagtag aagttgatga agatacaatg tcttcagtga aaatcctata tgtaagaaat      660

cttatgctgt ctacctctga agagatgatt gaaaaggaat tcaacaatat caaaccaggt      720

gctgtggaga gggtgaagaa aattcgagac tatgcttttg tgcacttcag taaccgagaa      780

gatgcagttg aggctatgaa agctttaaat ggcaaggtgc tggatggttc ccccattgaa      840

gtcaccctag caaaaccagt ggacaaggac agttatgtta ggtatacccg aggcacaggt      900

ggaaggggca ccatgctgca aggagagtat acctactctt tgggccaagt ttatgatccc      960

accacaacct accttggagc tcctgtcttc tatgcccccc agacctatgc agcaattccc     1020

agtcttcatt tcccagccac caaaggacat ctcagcaaca gagccattat ccgagcccct     1080

tctgttagag gggctgcggg agtgagagga ctgggcggcc gtggctattt ggcatacaca     1140

ggcctgggtc gaggatacca ggtcaaagga gacaaaagag aagacaaact ctatgacatt     1200

ttacctggga tggagctcac cccaatgaat cctgtcacat taaaacccca aggaattaaa     1260

ctcgctcccc agatattaga agagatttgt cagaaaaata actggggaca gccagtgtac     1320

cagctgcact ctgctattgg acaagaccaa agacagctat tcttgtacaa aataactatt     1380

cctgctctag ccagccagaa tcctgcaatc caccctttca cacctccaaa gctgagtgcc     1440

tttgtggatg aagcaaagac gtatgcagcc gaatacaccc tgcagaccct gggcatcccc     1500

actgatggag gcgatggcac catggctact gctgctgctg ctgctactgc tttcccagga     1560

tatgctgtcc ctaatgcaac tgcacccgtg tctgcagccc agctcaagca agcggtaacc     1620

cttggacaag acttagcagc atatacaacc tatgaggtct acccaacttt tgcagtgact     1680

gcccgagggg atggatatgg caccttctga agatgctttt ttaaatttaa gaataagaca     1740

cacaaaactc tattaaaaaa aaaaaagaaa taaacctcta actcggtccc caatgatcat     1800

aaataatatg tttcctaaag aaatgccttt ccagagactg tatagcttat accaattata     1860

gaatcatgaa gt                                                         1872


<210> 2387
<211> 2230
<212> DNA
<213> Homo sapiens

<400> 2387
ataatcaagg aaaccttttc cgggtgggga tctctgaaat tactcagata acagtgctgt       60

gccaaaaacc tgtggatttt ctctacaaaa attatcatga ctgttatctt tttgatggaa      120

aagatgaagt tcagcgaaga acaaatctac aacttggcca gaagactgta gactttgcct      180

tcaaagagtg agcaacccta attaacctga ttttttgctg ataatcactc tcaatggaat      240

caaatcacaa atccggggat ggattgagcg gcactcagaa ggaagcagcc ctccgcgcac      300

tggtccagcg cacaggatat agcttggtcc aggaatttag aggttcctat agatggaagc      360

agtgtgtctg ggcacatgcc cagagccaga agcgagcatg agcacagcaa ttcctggcct      420

caaaaaagga aataatgctt tgcagtccat cattttgcaa actttgctgg aaaaggaaaa      480

tggacaaaga aaatatggtg gccctccacc tggttgggat gctgcacccc ctgaaagggg      540

ctgtgaaatt tttattggaa aacttccccg agaccttttt gaggatgagc ttataccatt      600

atgtgaaaaa atcggtaaaa tttatgaaat gagaatgatg atggatttta atggcaacaa      660

tagaggatat gcatttgtaa cattttcaaa taaagtggaa gccaagaatg caatcaagca      720

acttaataat tatgaaatta gaaatgggcg cctcttaggg gtttgtgcca gtgtggacaa      780

ctgccgatta tttgttgggg gcatcccaaa aaccaaaaag agagaagaaa tcttatcgga      840

gatgaaaaag gttactgaag gtgttgtcga tgtcatcgtc tacccaagcg ctgcagataa      900

aaccaaaaac cgaggctttg ccttcgtgga gtatgagagt catcgagcag ctgccatggc      960

gaggaggaaa ctgctaccag gaagaattca gttatgggga catggtattg cagtagactg     1020

ggcagagcca gaagtagaag ttgatgaaga tacaatgtct tcagtgaaaa tcctatatgt     1080

aagaaatctt atgctgtcta cctctgaaga gatgattgaa aaggaattca acaatatcaa     1140

accaggtgct gtggagaggg tgaagaaaat tcgagactat gcttttgtgc acttcagtaa     1200

ccgagaagat gcagttgagg ctatgaaagc tttaaatggc aaggtgctgg atggttcccc     1260

cattgaagtc accctagcaa aaccagtgga caaggacagt tatgttaggt atacccgagg     1320

cacaggtgga aggggcacca tgctgcaagg agagtatacc tactctttgg gccaagttta     1380

tgatcccacc acaacctacc ttggagctcc tgtcttctat gccccccaga cctatgcagc     1440

aattcccagt cttcatttcc cagccaccaa aggacatctc agcaacagag ccattatccg     1500

agccccttct gttagagaaa tttacatgaa tgtacctgta ggggctgcgg gagtgagagg     1560

actgggcggc cgtggctatt tggcatacac aggcctgggt cgaggatacc aggtcaaagg     1620

agacaaaaga gaagacaaac tctatgacat tttacctggg atggagctca ccccaatgaa     1680

tcctgtcaca ttaaaacccc aaggaattaa actcgctccc cagatattag aagagatttg     1740

tcagaaaaat aactggggac agccagtgta ccagctgcac tctgctattg gacaagacca     1800

aagacagcta ttcttgtaca aaataactat tcctgctcta gccagccaga atcctgcaat     1860

ccaccctttc acacctccaa agctgagtgc ctttgtggat gaagcaaaga cgtatgcagc     1920

cgaatacacc ctgcagaccc tgggcatccc cactgatgga ggcgatggca ccatggctac     1980

tgctgctgct gctgctactg ctttcccagg atatgctgtc cctaatgcaa ctgcacccgt     2040

gtctgcagcc cagctcaagc aagcggtaac ccttggacaa gacttagcag catatacaac     2100

ctatgaggtc tacccaactt ttgcagtgac tgcccgaggg gatggatatg gcaccttctg     2160

aagatgcttt tttaaattta agaataagac acacaaaact ctattaaaaa aaaaaaagaa     2220

ataaacctct                                                            2230


<210> 2388
<211> 1970
<212> DNA
<213> Homo sapiens

<400> 2388
tttgatatga cgattagagc ataacccgag tgacacgttg aattcgccat aatcaaggaa       60

accttttccg ggtggggatc tctgaaatta ctcagataac agtgctgtgc caaaaacctg      120

tggattttct ctacaaaaat tattgagcaa ccctaattaa cctgattttt tgctgataat      180

cactctcaat ggaatcaaat cacaaatccg gggatggatt gagcggcact cagaaggaag      240

cagccctccg cgcactggtc cagcgcacag gatatagctt ggtccaggaa aatggacaaa      300

gaaaatatgg tggccctcca cctggttggg atgctgcacc ccctgaaagg ggctgtgaaa      360

tttttattgg aaaacttccc cgagaccttt ttgaggatga gcttatacca ttatgtgaaa      420

aaatcggtaa aatttatgaa atgagaatga tgatggattt taatggcaac aatagaggat      480

atgcatttgt aacattttca aataaagtgg aagccaagaa tgcaatcaag caacttaata      540

attatgaaat tagaaatggg cgcctcttag gggtttgtgc cagtgtggac aactgccgat      600

tatttgttgg gggcatccca aaaaccaaaa agagagaaga aatcttatcg gagatgaaaa      660

aggttactga aggtgttgtc gatgtcatcg tctacccaag cgctgcagat aaaaccaaaa      720

accgaggctt tgccttcgtg gagtatgaga gtcatcgagc agctgccatg gcgaggagga      780

aactgctacc aggtgctgtg gagagggtga agaaaattcg agactatgct tttgtgcact      840

tcagtaaccg agaagatgca gttgaggcta tgaaagcttt aaatggcaag gtgctggatg      900

gttcccccat tgaagtcacc ctagcaaaac cagtggacaa ggacagttat gttaggtata      960

cccgaggcac aggtggaagg ggcaccatgc tgcaaggaga gtatacctac tctttgggcc     1020

aagtttatga tcccaccaca acctaccttg gagctcctgt cttctatgcc ccccagacct     1080

atgcagcaat tcccagtctt catttcccag ccaccaaagg acatctcagc aacagagcca     1140

ttatccgagc cccttctgtt agagaaattt acatgaatgt acctgtaggg gctgcgggag     1200

tgagaggact gggcggccgt ggctatttgg catacacagg cctgggtcga ggataccagg     1260

tcaaaggaga caaaagagaa gacaaactct atgacatttt acctgggatg gagctcaccc     1320

caatgaatcc tgtcacatta aaaccccaag gaattaaact cgctccccag atattagaag     1380

agatttgtca gaaaaataac tggggacagc cagtgtacca gctgcactct gctattggac     1440

aagaccaaag acagctattc ttgtacaaaa taactattcc tgctctagcc agccagaatc     1500

ctgcaatcca ccctttcaca cctccaaagc tgagtgcctt tgtggatgaa gcaaagacgt     1560

atgcagccga atacaccctg cagaccctgg gcatccccac tgatggaggc gatggcacca     1620

tggctactgc tgctgctgct gctactgctt tcccaggata tgctgtccct aatgcaactg     1680

cacccgtgtc tgcagcccag ctcaagcaag cggtaaccct tggacaagac ttagcagcat     1740

atacaaccta tgaggtctac ccaacttttg cagtgactgc ccgaggggat ggatatggca     1800

ccttctgaag atgctttttt aaatttaaga ataagacaca caaaactcta ttaaaaaaaa     1860

aaaagaaata aacctctaac tcggtcccca atgatcataa ataatatgtt tcctaaagaa     1920

atgcctttcc agagactgta tagcttatac caattataga atcatgaagt                1970


<210> 2389
<211> 1442
<212> DNA
<213> Homo sapiens

<400> 2389
tttagcctct tccctgcagt ggacaatgag gaggctgcac tgctgcatga agaggctacc       60

atgactattg aagagctgct gacacgctac gggcagaact gtcacaaggg ccctccccac      120

agcaaatctg gagcctctga caagctgcct cgagttgcta agtccaagtt ctttgaggac      180

agtgaggatg agtcagatga ggcggaggaa gaagaggaag acagtgagga atgcagcgag      240

gaagaggatg gctacagcag tgaggaggca gagaatgagg aagatgagga tgacaccgag      300

gaggctgaag aggacgatga agaagaagaa gaagagatga tggtgccagg gatggaaggc      360

aaagaggagc ctggctctga cagtggtaca acagcggtgg tggccctgat acgagggaag      420

cagttgattg tagccaacgc aggagactct cgctgtgtgg tatctgaggc tggcaaagct      480

ttagacatgt cctatgatca caaaccagag gatgaagtag aactagcacg catcaagaat      540

gctggtggca aggtcaccat ggatgggcga gtcaacgggg gcctcaacct ctccagagcc      600

attggggacc acttctataa gagaaacaag aacctgccac ctgaggaaca gatgatttca      660

gcccttcctg acatcaaggt gctgactctc actgacgacc atgaattcat ggtcattgcc      720

tgtgatggca tctggaatgt gatgagcagc caggaagttg tagatttcat tcaatcaaag      780

atcagccagc gtgatgaaaa tggggagctt cggttattgt catccattgt ggaagagctg      840

ctggatcagt gcctggcacc agacacttct ggggatggta cagggtgtga caacatgacc      900

tgcatcatca tttgcttcaa gccccgaaac acagcagagc tccagccaga gagtggcaag      960

cgaaaactag aggaggtgct ctctactgag ggggctgaag aaaatggcaa cagcgacaag     1020

aagaagaagg ccaagcgaga ctagcagtca tccagacccc tgcccaccta gactgttttc     1080

tgagccctcc ggacctgaga ctgagttttg tctttttcct ttagccttag cagtgggtat     1140

gaggtgtgca gggggagctg ggtggcttca ctccgcccat tccaaagagg gctctccctc     1200

cacactgcag ccgggagcct ctgctgtcct tcccagccgc ctctgctcct cgggctcatc     1260

accggttctg tgcctgtgct ctgttgtgtt ggagggaagg actggcggtt ctggttttta     1320

ctctgtgaac tttatttaag gacattcttt tttattggcg gctccatggc cctcggccgc     1380

ttgcacccgc tctctgttgt acactttcaa tcaacacttt ttcagactaa aggccaaaac     1440

ct                                                                    1442


<210> 2390
<211> 1902
<212> DNA
<213> Homo sapiens

<400> 2390
actgccgctg ccgcggctac ctgcggttca tctccgcaca ttccacacgc ggcccaaacg       60

gtctctctct ctctctctca aacaccgcct ttccgtcttt gttttatctt gagtagctta      120

gaaagattgg agaagaaagc ttacgtggaa tgaaaatcaa cttttatgga tattttgagg      180

actaaaagaa taaatagggc gtccgtactg tagcgaaagt gcgactaagg ttaggcatct      240

ggatttcccc cgtagccctc tttcaccccc cccccccggc cattaccgaa gcggatgaaa      300

acaaacacta acgatggcgg cgccgggaag cgaccggctg ctgggcttaa ggcgggagtg      360

accgcttaac cagtgaggga agcactgaag agcgccagtc gacgtgggtg cgacaactcg      420

cggagtctta ggagcaaaac gtctggggcc tgcgagccag gacccttctg aagccttagg      480

tgtctatcgg cgacgtgtac ggtcactgca gctccggagc gcggaaccct cagccaggag      540

gcgcggctgg tcggtcccag gtcccggcct ccgtaatgag agcccggaac cactctttgt      600

gccgcagctt cgcagcatct tggactcaag tgattctcct gcctcagcct cctgagtagc      660

tgggactaca gattcctata ggcaatggaa actgatctca attcccagga cagaaaggac      720

ctggacaagt ttattaaatt ttttgccctc aagactgtcc aagtgattgt ccaggctcgg      780

cttggtgaaa agatttgcac tcgttcatca tcttctccaa cgggttcaga ttggttcaac      840

ttagcaatca aagacatccc agaggttaca catgaagcaa agaaggcact ggcaggacag      900

ctgcctgcag tcgggaggtc catgtgtgtg gagatttcac ttaagacttc tgagggagat      960

tccatggagc tggaaatatg gtgtcttgaa atgaatgaaa agtgtgataa agaaatcaaa     1020

gtttcctaca cggtgtacaa cagactgtca ttgctgctga agtcccttct tgctataact     1080

agggtgacac cagcctatag gctctccagg aaacaagggc atgaatatgt catattatac     1140

aggatatatt ttggagaagt tcagctgagt ggcttaggag aaggcttcca gacagttcgt     1200

gttgggacag tgggcacccc tgtgggcacc atcactcttt cttgtgctta cagaattaac     1260

ttggcattca tgtctaccag gcaatttgag aggaccccac ctatcatggg gattattatt     1320

gatcactttg tggaccgtcc ctatcccagc tcctctccca tgcacccctg caattacaga     1380

actgctggtg aggacactgg agtaatatac ccgtctgtag aagactctca agaagtgtgt     1440

accacctctt tttccacctc cccaccatcc cagctgatgg ttcctgggaa ggaaggtggg     1500

gtaccccttg ctcccaacca gcctgtccat ggtacccagg ctgaccagga gagactggca     1560

acctgcaccc cttctgacag aacccactgt gctgccacac cctccagtag tgaggatact     1620

gaaaccgtat caaacagcag tgagggacgg gcctcccctc acgatgtctt ggagaccatc     1680

tttgtccgaa aagtgggggc ttttgtcaac aaacccatta accaggtgac cctgacgagt     1740

ttggatatac cctttgccat gtttgctccc aagaatttgg agctggagga taccgatcca     1800

atggtgaatc ctccagattc cccagagact gaatctcctc tccagggcag cctgccttgc     1860

agctggcccc ttccctgcct gctgtcacca tccactgttt ga                        1902


<210> 2391
<211> 3485
<212> DNA
<213> Homo sapiens

<400> 2391
gtcagtcccc gcgcttttcg gaggctgcca gcgtcccaca ccagccgcag gtgaaaaccg       60

gcagaaagac attaagagat tttcctgcag tcactgctgg cagatgatag agccaggatt      120

tgaaagcagg cagcctggct ccagaccctg tgctcttaac tcccgttttg catcaagaac      180

agaatcctat gaaaggcttg cacagtgctt ggatagcagc atcaaggagc attgtgtaca      240

tgcagaagtg cacagtacct ggagtgaaac tgcttgtgtt cgatttctga taccattcat      300

aactggctgt gtgatctcaa aacctctaaa atgcagacct ccagctctag atctgtgcac      360

ctgagtgaat ggcagaagaa ttacttcgca attacatctg gcatatgtac cggaccgaag      420

gcagatgcat accgtgcaca gatattacgc attcagtatg catgggcaaa ctctgagatt      480

tcccaggtct gtgctaccaa actgttcaaa aaatatgcag agaaatattc tgcaattatt      540

gattctgaca atgttgaatc tgggttgaat aattatgcag aaaacatttt aactttggca      600

ggatctcaac aaacagatag tgacaagtgg cagtctggat tgtcaataaa taatgttttc      660

aaaatgagta gtgtacagaa gatgatgcaa gctggcaaaa aattcaaaga ctctctgttg      720

gaacctgctc ttgcatcagt ggtaatccat aaggaggcca ctgtctttga tcttcctaaa      780

tttagtgttt gtggtagttc tcaagagagt gactcattac ctaactcagc tcatgatcga      840

gaccggaccc aagacttccc ggagagcaat cgtttgaaac tccttcagaa tgcccagcca      900

cctatggtga ctaacactgc taggacttgt cctacattct cagcacctgt aggtgagtca      960

gctactgcaa aattccatgt cacaccattg tttggaaatg tcaaaaagga aaatcacagc     1020

tctgcaaaag aaaacatagg acttaatgtg ttcttatcta accagtcttg ttttcctgct     1080

gcctgtgaaa atccacagag gaagtctttt tatggttctg gcaccattga tgcactttcc     1140

aatccaatac tgaataaggc ttgtagtaaa acagaagata atggcccaaa ggaggatagc     1200

agcctgccta catttaaaac tgcaaaagaa caattatggg tagatcagca aaaaaagtac     1260

caccaacctc agcgtgcatc agggtcttca tatggtggtg taaaaaagtc tctaggagct     1320

agtagatccc gagggatact tggaaagttt gttcctccta tacccaagca agatggggga     1380

gagcagaatg gaggaatgca atgtaagcct tatggggcag gacctacaga accagcacat     1440

ccagttgatg agcgtctgaa gaacttggag ccaaagatga ttgaacttat tatgaatgag     1500

attatggatc atggacctcc agtaaattgg gaagatattg caggagtaga atttgctaaa     1560

gccaccataa aggaaatagt tgtgtggccc atgttgaggc cagacatctt tactggttta     1620

aggggacccc ctaaaggaat tttgctcttt ggtcctcctg ggactggtaa aactctaatt     1680

ggcaagtgca ttgctagtca gtctggggca acattcttta gcatctctgc ttcatcctta     1740

acttctaaat gggtaggtga gggggagaaa atggtccgtg cattgtttgc tgttgcaagg     1800

tgtcagcaac cagctgtgat atttattgac gaaattgatt ccttgttatc tcaacgggga     1860

gatggtgagc atgaatcttc tagaaggata aaaacagaat ttttagttca attagatgga     1920

gcaacaacat cttctgaaga tcgtatccta gtggtgggag caacaaatcg gccacaagaa     1980

attgatgagg ctgcccggag aagattggtg aaaaggcttt atattcccct cccagaagct     2040

tcagccagga aacagatagt aattaatcta atgtccaaag agcagtgttg cctcagtgaa     2100

gaagaaattg aacagattgt acagcagtct gatgcgtttt caggagcaga catgacacag     2160

ctttgcaggg aggcttctct tggtcctatt cgcagtttac aaactgctga cattgctacc     2220

ataacaccgg atcaagttcg acccatagct tacattgatt ttgaaaatgc ttttagaact     2280

gtgcgaccta gtgtttctcc aaaagattta gagctttatg aaaactggaa caaaactttt     2340

ggttgtggaa agtaagtggg atacttggaa tcaaggcatc tctgtagtac agtcttcttt     2400

attttttagc atagaaagtt ggggatgtgt taattgtatt tttaagaata tattctaagt     2460

tctgtacttc aaataatagc acagatttta catctgattg acatagtgta tgttaatgta     2520

agttttgctt tccagtgatt acctgatacg taagcctatt tgaacaaagt gagaatgaac     2580

ttttgtttct aagaagtctt tatcttgaag ctatataaca tgaaaagtga gctcaaattt     2640

tttttagttg aagattacat ataaagttgt gtctgattaa tattcatctt ttattgaaga     2700

aagtgccttc tgatggccac ataattctta atgtcagcta gtataatggt ttacatttgg     2760

acaaagtatt gcttagtgtt atttaagtag atttaagatc tcaaagctaa agtgccaatt     2820

tttactttct tcagccaatt tgttacctct tttatggttt ttaattttta tcaggactaa     2880

cattttcaga aatagcaagg tgtgatctag tattagattc acagaactga aaggttaatt     2940

aagaatgttg gttattttca cgggagcgtg tgatatttaa cattaatatt ttatttgaca     3000

ctacagcctg taatactgct ctctttcaaa aacaagtttt cagattttta taacagaccc     3060

attttgtttt atgaaacatg ttcattacag aaacatgaga aaatagagat aagtaaaaag     3120

aataaaagtc actattatcc taccactttg cgggacacac tattaatatt taagcataga     3180

ttcttccaga tgttttgttt tatacagcag taggattgtg taatgtattc tctcttgtag     3240

cctattcttc aaagcgtatc ttcactttcc atgttaacat aaatgtcctt ttatgattgt     3300

ctaggattcc atggatggat ggaatataat tgagtcatct ggtagagcgc atataggaca     3360

ggacgctagg ttgtttatct tttgtttatt gtaaaggaac tatgtgggat gcatttggtg     3420

atctttttaa aaaatgtata aatttcttga gtaattcctg gattaaagaa tatgcacttt     3480

ttaaa                                                                 3485


<210> 2392
<211> 5546
<212> DNA
<213> Homo sapiens

<400> 2392
agattagaaa cttcgggtgg agagggcggc ggcgttgaat gtgtggcgga agcgctgggg       60

gtcacggctc cgcgcgccgc cggacagccg gcggcgtctc cacagcatga attacccggg      120

ccgcgggtcc ccacggagcc ccgagcataa cggccgaggc ggcggcggcg gcgcctggga      180

gctgggctca gacgcgaggc cagcgttcgg cggcggcgtc tgctgcttcg agcacctgcc      240

cggcggggac ccggacgacg gcgacgtgcc cctggccctg ctgcgcgggg aacccgggct      300

gcatttggcg ccgggcaccg acgaccacaa ccaccacctc gcgctggacc cctgcctcag      360

tgacgagaac tatgacttca gctccgccga gtcgggctcc tcgctgcgct actacagcga      420

gggtgagagc ggcggcggcg gcagctcctt gtcgctgcac ccgccgcagc agcctccgct      480

ggtcccgacg aactcggggg gcggcggcgc gacaggaggg tcccccgggg aaaggaaacg      540

tacccggctt ggcggcccgg cggcccggca ccgctatgag gtagtgacgg agctgggccc      600

ggaggaggta cgctggttct acaaggagga caagaagacc tggaagccct tcatcggcta      660

cgactcgctc cgcatcgagc tcgccttccg gaccctgctg cagaccacgg gtgcccggcc      720

ccagggcggg gaccgggacg gcgaccatgt gtgctccccc acgggcccag cctccagttc      780

cggagaagat gacgatgagg accgcgcctg cggcttctgc cagagtacga cggggcacga      840

gccggagatg gtggagcttg tgaacatcga gcctgtgtgc gtgcggggcg gcctctacga      900

ggtggatgtg acccaaggag agtgctaccc ggtgtactgg aaccaggctg ataaaatacc      960

agtaatgcgt ggacagtggt ttattgacgg cacttggcag cctctagaag aggaagaaag     1020

taatttaatt gagcaagaac atctcaattg ttttaggggc cagcagatgc aggaaaattt     1080

cgatattgaa gtgtcaaaat ccatagatgg aaaagatggc agtgggatca actattctgc     1140

tgttcatagt ttcaagttga gtcgaaacca tgtggactgg cacagtgtgg atgaagtata     1200

tctttatagt gatgcaacaa catctaaaat tgcaagaaca gttacccaaa aactgggatt     1260

ttctaaagca tcaagtagtg gtaccagact tcatagaggt tatgtagaag aagccacatt     1320

agaagacaag ccatcacaga ctacccatat tgtatttgtt gtgcatggca ttgggcagaa     1380

aatggaccaa ggaagaatta tcaaaaatac agctatgatg agagaagctg caagaaaaat     1440

agaagaaagg catttttcca accatgcaac acatgttgaa tttctgcctg ttgagtggcg     1500

gtcaaaactt actcttgatg gagacactgt tgattccatt actcctgaca aagtacgagg     1560

tttaagggat atgctgaaca gcagtgcaat ggacataatg tattatacta gtccacttta     1620

tagagatgaa ctagttaaag gccttcagca agagctgaat cgattgtatt cccttttctg     1680

ttctcggaat ccagactttg aagaaaaagg gggtaaagtc tcaatagtat cacattcctt     1740

gggatgtgta attacttatg acataatgac tggctggaat ccagttcggc tgtatgaaca     1800

gttgctgcaa aaggaagaag agttgcctga tgaacgatgg atgagctatg aagaacgaca     1860

tcttcttgat gaactctata taactaaacg acggctgaag gaaatagaag aacggcttca     1920

cggattgaaa gcatcatcta tgacacaaac acctgcctta aaatttaagg ttgagaattt     1980

cttctgtatg ggatccccat tagcagtttt cttggcgttg cgtggcatcc gcccaggaaa     2040

tactggaagt caagaccata ttttgcctag agagatttgt aaccggttac taaatatttt     2100

tcatcctaca gatccagtgg cttatagatt agaaccatta atactgaaac actacagcaa     2160

catttcacct gtccagatcc actggtacaa tacttcaaat cctttacctt atgaacatat     2220

gaagccaagc tttctcaacc cagctaaaga acctacctca gtttcagaga atgaaggcat     2280

ttcaaccata ccaagccctg tgacctcacc agttttgtcc cgccgacact atggagaatc     2340

tataacaaat ataggcaaag caagcatatt aggggctgct agcattggaa agggacttgg     2400

aggaatgttg ttctcaagat ttggacgttc atctacaaca cagtcatctg aaacatcaaa     2460

agactcaatg gaagatgaga agaagccagt tgcctcacct tctgctacca ccgtagggac     2520

acagaccctt ccacatagca gttctggctt cctcgattct gcattggagt tggatcacag     2580

gattgatttt gaactcagag aaggccttgt ggagagccgc tattggtcag ctgtcacgtc     2640

gcatactgcc tattggtcat ccttggatgt tgcccttttt cttttaacct tcatgtataa     2700

acatgagcac gatgatgatg caaaacccaa tttagatcca atctgaactc tcttgaagga     2760

catgaatggc ctaaaactga tttttttttt ttccgttaaa atgtgtgtgt caagatacgg     2820

agatttcagg gttaaagtat atttcagttt tctttagggc aacatatatt tgaatttaaa     2880

agcactttat ttaaaaaaaa aagaagtttt cagttctgaa gaagtcattt acagtttgca     2940

tcattttaat tatgagtctg acaaaacctt ctccagagaa tcaagcaaga cctggatgtg     3000

aagaaggttt gggtaaactg catgtaaagg ctacaaatca caatctgatt cctcccaaat     3060

ataaaggcat atggaacata atgtattaac caaagtatgt tataaatcaa aaatggtcaa     3120

ggttcagcat attctatatg aagatcacaa ggtggtatcg ttttagattt ctatgaaggc     3180

tttcatttgt acatcccttt gaaaaaatat aacagattta aaatgttttg aatttaactt     3240

gtttagaaaa actaatgctt aaaacaatat ttgaactact gtatttataa tttattacct     3300

ctaattgctt tatttcagtg tatgagacat tactgtttta atgtttgctt tgaacataat     3360

ttaagaacca gatttatttt ctatagtgat aaaccctttt ttctcagaac tccatctttg     3420

tactcttcag atgaatatat agacactgtg gcatacattt tttttcatta aaaacttatg     3480

gcttcataca acactagttc aattttttaa ataaactttt tattatgtta catgtacttc     3540

agagaaagct aaagtttctc taaacttgac acggagtact ccataatggg tacatttcat     3600

tagctttatt agaaaactag taaatgcttt tgaataggta gtatgacagc tattttaaat     3660

gtataaacat ttgtgtgcca aacaacatat atgaagggat gtgatgccac taactagtgc     3720

acattgtttc tcaatgtgcc attgagacac aaggcacagt aagtcaggat tctgaggcat     3780

tggaagggtt ttcttcagct gtaattgttt ccacagtgct tttcatctga ggggctcaaa     3840

gtttaagagt gcattcaata acccatgtac tagcttcttg aggtaagtaa ataaatcttg     3900

ttctcatgtt acatgttaat acaccaaggc accaaaacat ttaaagtgcc atgaattaga     3960

ttacatcaga aatcagaaaa gcttggattg agctagtcac cgtggttcac gcctgtaatc     4020

ccaacacttc gggaggccaa gatgggagga tctcttgagc ccaggatttc aagaccagct     4080

tgggcaacat agtgagaccc tcttctctgc aaaaactgac aaaaattagc cacttgtagt     4140

ggtgtacacc tgtagtccca gctactcaag aggctgaggt gggaggatca cccgagccca     4200

gaagttcaaa gctgcagtga gctctgatca caccaatgca ctccagcctg ggtgacagag     4260

ccagaccctg tctctaaaaa acaaaaaaga aaagcttggg ttgaagccag gccatattct     4320

tttatatgct gttcaatgac ttgattcaca tgtgaccttt tagtagtttg caaacaataa     4380

taacagaagt tgcaattcat aattcagaga aatgaccatg aagccggtgt ttccctgctt     4440

gatttctatg ttcttggatt ctcacacaaa agaggagtta cctagagggg atcagtagcc     4500

atccctgttg cacacaaccc tcacttctga gtggtttcca ctaggttcca cttaaggtgc     4560

tgtcttttct taacttgcaa ggaattgctt agcttcccaa taatcattgt caaactggga     4620

gcaaagttgg tcagctgtat ctctcacctc ctcctttctt cataagatag tagaatctgt     4680

ggcttacttg taggttttac ttagtgcttc agtactgttg gctgttttgg ccttttgctg     4740

aatttgcaca acaacataaa gcacttcttt ttaatgttta aaaaaaattc caaggctcca     4800

tgaccaagta tgtgactcac taagaaaccc ttgctataaa aggcttttga tgaaatctta     4860

gcaaagctaa attatctcta acttagagat tcctatgaac tcaggtcatt ttcatagcct     4920

gtttattttg taggtctaat ttagttctca ggaaaattaa actcatgcta tatgactgta     4980

tcgttaaagg tacttgagcg tatgttgctg taggtggtat gacactcaaa tgcataagaa     5040

cttgaaggga tttattctta accactagaa tatgaagagc cctttttacc tgagaagagt     5100

gaaattatgt cagacctttt aatttgatat cactgagtaa aaggtatgtt cctatagcca     5160

taggaatatg tctgcttcct ttttttcatg ttgagaaaac agtcaaattt aaccatttgg     5220

agtttatttg aattcttgga aagagcaata ttcaaaacct tttcaaaaat aagatattct     5280

ggactactgg atggatgttt tgttttcagt tcatttttca tcagtagaga tggtgatttc     5340

ggttttgtag tatccttgtt tctatgtctg tgcatgttaa cattggatgt atttgtatat     5400

acttaattaa tatacagact gtgtgtcatt ctggcttgat tagaagctaa gtcagttact     5460

gagtaacatt ttgcaacttt attccagcaa gtactaaatc ggccaaaaaa agttttgttt     5520

ttgataccat taaaatttta ttctct                                          5546


<210> 2393
<211> 2929
<212> DNA
<213> Homo sapiens

<400> 2393
ctcgggtcgg gatttgaaag attagaaact tcgggtggag agggcggcgg cgttgaatgt       60

gtggcggaag cgctgggggt cacggctccg cgcgccgccg gacagccggc ggcgtctcca      120

cagcatgaat tacccgggcc gcgggtcccc acggagcccc gagcataacg gccgaggcgg      180

cggcggcggc gcctgggagc tgggctcaga cgcgaggcca gcgttcggcg gcggcgtctg      240

ctgcttcgag cacctgcccg gcggggaccc ggacgacggc gacgtgcccc tggccctgct      300

gcgcggggaa cccgggctgc atttggcgcc gggcaccgac gaccacaacc accacctcgc      360

gctggacccc tgcctcagtg acgagaacta tgacttcagc tccgccgagt cgggctcctc      420

gctgcgctac tacagcgagg gtgagagcgg cggcggcggc agctccttgt cgctgcaccc      480

gccgcagcag cctccgctgg tcccgacgaa ctcggggggc ggcctctacg aggtggatgt      540

gacccaagga gagtgctacc cggtgtactg gaaccaggct gataaaatac cagtaatgcg      600

tggacagtgg tttattgacg gcacttggca gcctctagaa gaggaagaaa gtaatttaat      660

tgagcaagaa catctcaatt gttttagggg ccagcagatg caggaaaatt tcgatattga      720

agtgtcaaaa tccatagatg gaaaagatgc tgttcatagt ttcaagttga gtcgaaacca      780

tgtggactgg cacagtgtgg atgaagtata tctttatagt gatgcaacaa catctaaaat      840

tgcaagaaca gttacccaaa aactgggatt ttctaaagca tcaagtagtg gtaccagact      900

tcatagaggt tatgtagaag aagccacatt agaagacaag ccatcacaga ctacccatat      960

tgtatttgtt gtgcatggca ttgggcagaa aatggaccaa ggaagaatta tcaaaaatac     1020

agctatgatg agagaagctg caagaaaaat agaagaaagg catttttcca accatgcaac     1080

acatgttgaa tttctgcctg ttgagtggcg gtcaaaactt actcttgatg gagacactgt     1140

tgattccatt actcctgaca aagtacgagg tttaagggat atgctgaaca gcagtgcaat     1200

ggacataatg tattatacta gtccacttta tagagatgaa ctagttaaag gccttcagca     1260

agagctgaat cgattgtatt cccttttctg ttctcggaat ccagactttg aagaaaaagg     1320

gggtaaagtc tcaatagtat cacattcctt gggatgtgta attacttatg acataatgac     1380

tggctggaat ccagttcggc tgtatgaaca gttgctgcaa aaggaagaag agttgcctga     1440

tgaacgatgg atgagctatg aagaacgaca tcttcttgat gaactctata taactaaacg     1500

acggctgaag gaaatagaag aacggcttca cggattgaaa gcatcatcta tgacacaaac     1560

acctgcctta aaatttaagg ttgagaattt cttctgtatg ggatccccat tagcagtttt     1620

cttggcgttg cgtggcatcc gcccaggaaa tactggaagt caagaccata ttttgcctag     1680

agagatttgt aaccggttac taaatatttt tcatcctaca gatccagtgg cttatagatt     1740

agaaccatta atactgaaac actacagcaa catttcacct gtccagatcc actggtacaa     1800

tacttcaaat cctttacctt atgaacatat gaagccaagc tttctcaacc cagctaaaga     1860

acctacctca gtttcagaga atgaaggcat ttcaaccata ccaagccctg tgacctcacc     1920

agttttgtcc cgccgacact atggagaatc tataacaaat ataggcaaag caagcatatt     1980

aggggctgct agcattggaa agggacttgg aggaatgttg ttctcaagat ttggacgttc     2040

atctacaaca cagtcatctg aaacatcaaa agactcaatg gaagatgaga agaagccagt     2100

tgcctcacct tctgctacca ccgtagggac acagaccctt ccacatagca gttctggctt     2160

cctcgattct gcatatttca gacttcaaga atcgttcttt aatctcccac aacttctttt     2220

tccggaaaat gtaatgcaga ataaagataa tgccctcgtg gagttggatc acaggattga     2280

ttttgaactc agagaaggcc ttgtggagag ccgctattgg tcagctgtca cgtcgcatac     2340

tgcctattgg tcatccttgg atgttgccct ttttctttta accttcatgt ataaacatga     2400

gcacgatgat gatgcaaaac ccaatttaga tccaatctga actctcttga aggacatgaa     2460

tggcctaaaa ctgatttttt ttttttccgt taaaatgtgt gtgtcaagat acggagattt     2520

cagggttaaa gtatatttca gttttcttta gggcaacata tatttgaatt taaaagcact     2580

ttatttaaaa aaaaaagaag ttttcagttc tgaagaagtc atttacagtt tgcatcattt     2640

taattatgag tctgacaaaa ccttctccag agaatcaagc aagacctgga tgtgaagaag     2700

gtttgggtaa actgcatgta aaggctacaa atcacaatct gattcctccc aaatataaag     2760

gcatatggaa cataatgtat taaccaaagt atgttataaa tcaaaaatgg tcaaggttca     2820

gcatattcta tatgaagatc acaaggtggt atcgttttag atttctatga aggctttcat     2880

ttgtacatcc ctttgaaaaa atataacaga tttaaaatgt tttgaattt                 2929


<210> 2394
<211> 2870
<212> DNA
<213> Homo sapiens

<400> 2394
gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc ctgactcaca       60

ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg ggatgggaac      120

aacatgtctt cacctaggga ctttagagca gagcctggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct      540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaata gataccgaga      600

tattcttcca tatgattcaa cacgcgttcc tcttggaaaa agcaaggact acatcaatgc      660

tagttatatt agaatagtca attgtggaga agagtatttt tatatcgcta ctcaaggacc      720

actgctgagc accatagatg acttttggca aatggtgttg gaaaataatt caaatgttat      780

tgccatgata accagagaga tagaaggtgg aattatcaaa tgctaccatt actggcccat      840

ttctctgaag aagccattgg aattgaaaca cttccgtgta ttcctggaga actaccagat      900

acttcaatat ttcatcattc gaatgtttca agttgtggag aagtccacgg gaactagtca      960

ctctgtaaaa cagttgcagt tcaccaagtg gccagaccat ggcactcctg cctcagcaga     1020

tagcttcata aaatatattc gttatgcaag gaagagccac cttacaggac ccatggttgt     1080

tcactgcagt gccggcatag gccggacagg ggtgttccta tgtgtggatg tcgtgttctg     1140

tgccatcgta aagaactgtt cattcaacat catggatata gtggcccaaa tgagagaaca     1200

acgttctggc atggttcaaa cgaaggagca gtatcacttt tgttacgata ttgtgcttga     1260

agttcttcgg aaacttctga ctttggatta agaaagactt ctgttgcctc tcacttgaaa     1320

ttaccaagtg ggtttgcacc tcctcataaa gaacatgttt gcactgtgct gaagggcttt     1380

gctatgcata caatctgctt tcttggttta tcagtttatt ttctttctaa aagctccctg     1440

aagggcaata tcatttggct tggggtgatc agtgtttact tattgatctt gctagacaat     1500

atcaaaataa cttcccacat tttccagtga aacagatgtt acataaaacg attgcagctt     1560

ggctatttgg ttgaagggat tacagagccc aataaaggat ttaaaatata ttcattaaga     1620

ttttatttgg aaaggtggct ggagagagct gaggatttcc aggactttgt aagttcttat     1680

tctgggagaa cataaggcca ataatcatga cctcttccag gcatttttaa gacagatgtc     1740

tattcatgtt ctttagctag agcctgtact ttttgctggc atttgaataa cccagtttaa     1800

aaagagtcca gttagggtgg actaactttg gacacaaatt ggcttccatt tcctacattt     1860

tcatactgct gccttcctac agctgctaga ccaagacctg ttggtctggg aagcatttca     1920

tggataggga gagctcctct cggtgaacag tccaaaacta aaatagatgt ttatatagaa     1980

agcccaagag gagacttttg ccatgcctga gttctttcct atcccaccct aacacttaac     2040

atattactta gtctgctttg ttaaaagcaa gtattacctt taacttgcct cttactcttt     2100

gccctttagc taactaataa agtttgatat aggcattatt atataattct gagtcattca     2160

tggtatctct catgtttgat gtatttttca aactaagatc tatgatagtt ttttttccag     2220

agttccatta aatcatttat ttcctttact ttctcacctc tgttgaaaca tttagaaact     2280

ggatttggga acccaatttt ggaaaaccag attcatagtc atgaaaatgg aaacttccat     2340

attctgtttt tgaaaagatg tggccattat tacagtaatt ttattatagg actttgcctc     2400

gtacaattaa tagtgatatt ttggacaagg agttctggtg acaagctata cctaattata     2460

agctataaaa caatagatat gagtgtttgt acagtttaac tcaatggaga tcagaatatt     2520

ctatgtattg agaaaatgtt taatatcaat ctataaatct tgaatttcta agaggcttat     2580

tttgttcttt tggctgaatg agtatatttg aattggttga ataattaata attctcattg     2640

taaaaataat tatatgccaa aaatatattt gatgttaaat caaatagatg attctgttta     2700

cattgttcat atgaataata atctgtgtta atttcatttt gataattggc ctttaatatt     2760

tgtatctcta attttatttt ctctctgtta ctgtaaaata atagctataa tgtataacaa     2820

ttttcttcag aagaattcta tgctattatt aaaataaaat atttactgtg                2870


<210> 2395
<211> 2323
<212> DNA
<213> Homo sapiens

<400> 2395
gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc ctgactcaca       60

ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg ggatgggaac      120

aacatgtctt cacctaggga ctttagagca gagcctgtaa acgattatga gggaaatgac      180

tctgaagcag aagacttgaa tttcagggag actttgcctt catcaagtca ggaaaacaca      240

cctagatcaa aggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg      300

aatttcccac ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat      360

cccagcatgt ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag      420

gaggctgcag ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt      480

tctgaaggag aactagatca gttggctcag attcggccat taatattcaa ttttcatgag      540

cagacagcca tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc      600

atgcaggaat ttatgttcaa catcatggat atagtggccc aaatgagaga acaacgttct      660

ggcatggttc aaacgaagga gcagtatcac ttttgttacg atattgtgct tgaagttctt      720

cggaaacttc tgactttgga ttaagaaaga cttctgttgc ctctcacttg aaattaccaa      780

gtgggtttgc acctcctcat aaagaacatg tttgcactgt gctgaagggc tttgctatgc      840

atacaatctg ctttcttggt ttatcagttt attttctttc taaaagctcc ctgaagggca      900

atatcatttg gcttggggtg atcagtgttt acttattgat cttgctagac aatatcaaaa      960

taacttccca cattttccag tgaaacagat gttacataaa acgattgcag cttggctatt     1020

tggttgaagg gattacagag cccaataaag gatttaaaat atattcatta agattttatt     1080

tggaaaggtg gctggagaga gctgaggatt tccaggactt tgtaagttct tattctggga     1140

gaacataagg ccaataatca tgacctcttc caggcatttt taagacagat gtctattcat     1200

gttctttagc tagagcctgt actttttgct ggcatttgaa taacccagtt taaaaagagt     1260

ccagttaggg tggactaact ttggacacaa attggcttcc atttcctaca ttttcatact     1320

gctgccttcc tacagctgct agaccaagac ctgttggtct gggaagcatt tcatggatag     1380

ggagagctcc tctcggtgaa cagtccaaaa ctaaaataga tgtttatata gaaagcccaa     1440

gaggagactt ttgccatgcc tgagttcttt cctatcccac cctaacactt aacatattac     1500

ttagtctgct ttgttaaaag caagtattac ctttaacttg cctcttactc tttgcccttt     1560

agctaactaa taaagtttga tataggcatt attatataat tctgagtcat tcatggtatc     1620

tctcatgttt gatgtatttt tcaaactaag atctatgata gttttttttc cagagttcca     1680

ttaaatcatt tatttccttt actttctcac ctctgttgaa acatttagaa actggatttg     1740

ggaacccaat tttggaaaac cagattcata gtcatgaaaa tggaaacttc catattctgt     1800

ttttgaaaag atgtggccat tattacagta attttattat aggactttgc ctcgtacaat     1860

taatagtgat attttggaca aggagttctg gtgacaagct atacctaatt ataagctata     1920

aaacaataga tatgagtgtt tgtacagttt aactcaatgg agatcagaat attctatgta     1980

ttgagaaaat gtttaatatc aatctataaa tcttgaattt ctaagaggct tattttgttc     2040

ttttggctga atgagtatat ttgaattggt tgaataatta ataattctca ttgtaaaaat     2100

aattatatgc caaaaatata tttgatgtta aatcaaatag atgattctgt ttacattgtt     2160

catatgaata ataatctgtg ttaatttcat tttgataatt ggcctttaat atttgtatct     2220

ctaattttat tttctctctg ttactgtaaa ataatagcta taatgtataa caattttctt     2280

cagaagaatt ctatgctatt attaaaataa aatatttact gtg                       2323


<210> 2396
<211> 2226
<212> DNA
<213> Homo sapiens

<400> 2396
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc       60

ccaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc ggaatttccc      120

acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg atcccagcat      180

gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg aggaggctgc      240

agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg tttctgaagg      300

agaactagat cagttggctc agattcggcc attaatattc aattttcatg agcagacagc      360

catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata tcatgcagga      420

atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga atcaaccaag      480

caacagagaa aaaaatagat accgagatat tcttccattt caacatcatg gatatagtgg      540

cccaaatgag agaacaacgt tctggcatgg ttcaaacgaa ggagcagtat cacttttgtt      600

acgatattgt gcttgaagtt cttcggaaac ttctgacttt ggattaagaa agacttctgt      660

tgcctctcac ttgaaattac caagtgggtt tgcacctcct cataaagaac atgtttgcac      720

tgtgctgaag ggctttgcta tgcatacaat ctgctttctt ggtttatcag tttattttct      780

ttctaaaagc tccctgaagg gcaatatcat ttggcttggg gtgatcagtg tttacttatt      840

gatcttgcta gacaatatca aaataacttc ccacattttc cagtgaaaca gatgttacat      900

aaaacgattg cagcttggct atttggttga agggattaca gagcccaata aaggatttaa      960

aatatattca ttaagatttt atttggaaag gtggctggag agagctgagg atttccagga     1020

ctttgtaagt tcttattctg ggagaacata aggccaataa tcatgacctc ttccaggcat     1080

ttttaagaca gatgtctatt catgttcttt agctagagcc tgtacttttt gctggcattt     1140

gaataaccca gtttaaaaag agtccagtta gggtggacta actttggaca caaattggct     1200

tccatttcct acattttcat actgctgcct tcctacagct gctagaccaa gacctgttgg     1260

tctgggaagc atttcatgga tagggagagc tcctctcggt gaacagtcca aaactaaaat     1320

agatgtttat atagaaagcc caagaggaga cttttgccat gcctgagttc tttcctatcc     1380

caccctaaca cttaacatat tacttagtct gctttgttaa aagcaagtat tacctttaac     1440

ttgcctctta ctctttgccc tttagctaac taataaagtt tgatataggc attattatat     1500

aattctgagt cattcatggt atctctcatg tttgatgtat ttttcaaact aagatctatg     1560

atagtttttt ttccagagtt ccattaaatc atttatttcc tttactttct cacctctgtt     1620

gaaacattta gaaactggat ttgggaaccc aattttggaa aaccagattc atagtcatga     1680

aaatggaaac ttccatattc tgtttttgaa aagatgtggc cattattaca gtaattttat     1740

tataggactt tgcctcgtac aattaatagt gatattttgg acaaggagtt ctggtgacaa     1800

gctataccta attataagct ataaaacaat agatatgagt gtttgtacag tttaactcaa     1860

tggagatcag aatattctat gtattgagaa aatgtttaat atcaatctat aaatcttgaa     1920

tttctaagag gcttattttg ttcttttggc tgaatgagta tatttgaatt ggttgaataa     1980

ttaataattc tcattgtaaa aataattata tgccaaaaat atatttgatg ttaaatcaaa     2040

tagatgattc tgtttacatt gttcatatga ataataatct gtgttaattt cattttgata     2100

attggccttt aatatttgta tctctaattt tattttctct ctgttactgt aaaataatag     2160

ctataatgta taacaatttt cttcagaaga attctatgct attattaaaa taaaatattt     2220

actgtg                                                                2226


<210> 2397
<211> 2872
<212> DNA
<213> Homo sapiens

<400> 2397
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc       60

ccagtaaacg attatgaggg aaatgactct gaagcagaag acttgaattt cagggagact      120

ttgccttcat caagtcagga aaacacacct agatcaaagg tttttgaaaa taaagttaat      180

tcagagaagg taaaactttc tcttcggaat ttcccacata atgattatga ggatgttttt      240

gaagagcctt cagaaagtgg cagtgatccc agcatgtgga cagccagagg ccccttcaga      300

agagacaggt ggagcagtga ggatgaggag gctgcagggc catcacaggc tctctcccct      360

ctactttctg atacgcgcaa aattgtttct gaaggagaac tagatcagtt ggctcagatt      420

cggccattaa tattcaattt tcatgagcag acagccatca aggattgttt gaaaatcctt      480

gaggaaaaaa cagcagcgta tgatatcatg caggaattta tggctttaga acttaagaat      540

ctgcctggtg agttcaactc tgggaatcaa ccaagcaaca gagaaaaaaa tagataccga      600

gatattcttc catatgattc aacacgcgtt cctcttggaa aaagcaagga ctacatcaat      660

gctagttata ttagaatagt caattgtgga gaagagtatt tttatatcgc tactcaagga      720

ccactgctga gcaccataga tgacttttgg caaatggtgt tggaaaataa ttcaaatgtt      780

attgccatga taaccagaga gatagaaggt ggaattatca aatgctacca ttactggccc      840

atttctctga agaagccatt ggaattgaaa cacttccgtg tattcctgga gaactaccag      900

atacttcaat atttcatcat tcgaatgttt caagttgtgg agaagtccac gggaactagt      960

cactctgtaa aacagttgca gttcaccaag tggccagacc atggcactcc tgcctcagca     1020

gatagcttca taaaatatat tcgttatgca aggaagagcc accttacagg acccatggtt     1080

gttcactgca gtgccggcat aggccggaca ggggtgttcc tatgtgtgga tgtcgtgttc     1140

tgtgccatcg taaagaactg ttcattcaac atcatggata tagtggccca aatgagagaa     1200

caacgttctg gcatggttca aacgaaggag cagtatcact tttgttacga tattgtgctt     1260

gaagttcttc ggaaacttct gactttggat taagaaagac ttctgttgcc tctcacttga     1320

aattaccaag tgggtttgca cctcctcata aagaacatgt ttgcactgtg ctgaagggct     1380

ttgctatgca tacaatctgc tttcttggtt tatcagttta ttttctttct aaaagctccc     1440

tgaagggcaa tatcatttgg cttggggtga tcagtgttta cttattgatc ttgctagaca     1500

atatcaaaat aacttcccac attttccagt gaaacagatg ttacataaaa cgattgcagc     1560

ttggctattt ggttgaaggg attacagagc ccaataaagg atttaaaata tattcattaa     1620

gattttattt ggaaaggtgg ctggagagag ctgaggattt ccaggacttt gtaagttctt     1680

attctgggag aacataaggc caataatcat gacctcttcc aggcattttt aagacagatg     1740

tctattcatg ttctttagct agagcctgta ctttttgctg gcatttgaat aacccagttt     1800

aaaaagagtc cagttagggt ggactaactt tggacacaaa ttggcttcca tttcctacat     1860

tttcatactg ctgccttcct acagctgcta gaccaagacc tgttggtctg ggaagcattt     1920

catggatagg gagagctcct ctcggtgaac agtccaaaac taaaatagat gtttatatag     1980

aaagcccaag aggagacttt tgccatgcct gagttctttc ctatcccacc ctaacactta     2040

acatattact tagtctgctt tgttaaaagc aagtattacc tttaacttgc ctcttactct     2100

ttgcccttta gctaactaat aaagtttgat ataggcatta ttatataatt ctgagtcatt     2160

catggtatct ctcatgtttg atgtattttt caaactaaga tctatgatag ttttttttcc     2220

agagttccat taaatcattt atttccttta ctttctcacc tctgttgaaa catttagaaa     2280

ctggatttgg gaacccaatt ttggaaaacc agattcatag tcatgaaaat ggaaacttcc     2340

atattctgtt tttgaaaaga tgtggccatt attacagtaa ttttattata ggactttgcc     2400

tcgtacaatt aatagtgata ttttggacaa ggagttctgg tgacaagcta tacctaatta     2460

taagctataa aacaatagat atgagtgttt gtacagttta actcaatgga gatcagaata     2520

ttctatgtat tgagaaaatg tttaatatca atctataaat cttgaatttc taagaggctt     2580

attttgttct tttggctgaa tgagtatatt tgaattggtt gaataattaa taattctcat     2640

tgtaaaaata attatatgcc aaaaatatat ttgatgttaa atcaaataga tgattctgtt     2700

tacattgttc atatgaataa taatctgtgt taatttcatt ttgataattg gcctttaata     2760

tttgtatctc taattttatt ttctctctgt tactgtaaaa taatagctat aatgtataac     2820

aattttcttc agaagaattc tatgctatta ttaaaataaa atatttactg tg             2872


<210> 2398
<211> 1929
<212> DNA
<213> Homo sapiens

<400> 2398
gaagaagggc ggggatgtca gggctggaga gtgcccgtgt ccttctgtgt gcattgggct       60

ccttcctcct taattctctg ctttccactt ttaggctgaa ctccagtgca cccagttaga      120

cttggagcgg aaactcaagt tgaatgaaaa tgccatctcc aggctccagg ctaaccaaaa      180

gtctgttctg gtgtcggtgt cagaggtcaa agcagtggct gaaatgcagt ttggggaact      240

ccttgctgct gtgaggaagg cccaggccaa tgtgatgctc ttcttagagg agaaggagca      300

agctgcgctg agccaggcca acggtatcaa ggcccacctg gagtacagga gtgccgagat      360

ggagaagagt aagcaggagc tggagacgat ggcggccatc agcaacactg tccagttctt      420

ggaggagtac tgcaagttta agaacactga agacatcacc ttccctagtg tttacatagg      480

gctgaaggat aaactctcgg gcatccgcaa agttatcacg gaatccactg tacacttaat      540

ccagttgctg gagaactata agaaaaagct ccaggagttt tccaaggaag aggagtatga      600

catcagaact caagtgtctg ccattgttca gcgcaaatat tggacttcca aacctgagcc      660

cagcaccagg gaacagttcc tccaatatgt gcatgacatc acgttcgacc cggacacagc      720

acacaagtat ctccggctgc aggaggagaa ccgcaaggtc accaacacca cgccctggga      780

gcatccctac ccggacctcc ccagcaggtt cctgcactgg cggcaggtgc tgtcccagca      840

gagtctgtac ctgcacaggt actattttga ggtggagatc ttcggggcag gcacctatgt      900

tggcctgacc tgcaaaggca tcgaccagaa aggggaggag cgcagcagtt gcatttccgg      960

aaacaacttc tcctggagcc tccaatggaa cgggaaggag ttcacggcct ggtacagtga     1020

catggagacc ccactcaaag ctggcccttt ctggaggctc ggggtctata ttgacttccc     1080

aggagggatc ctttccttct atggcgtaga gtatgattcc atgactctgg ttcacaagtt     1140

tgcctgcaag ttttcagaac cagtctatgc tgccttctgg ctttccaaga aggaaaacgc     1200

catccggatt gtagatctgg gagaggaacc cgagaagcca gcaccgtcct tggtggggac     1260

tgctccctag actccaggag ccatatccca gacctttgcc agctacagtg atgggatttg     1320

cattttaggg tgatttgggg gcaaaaataa ctgctgatgg tagctggctt ttgaaatcct     1380

atggggtctc tgaatgaaaa cattctccag ctgctctctt ttgctccata tggtgctgtt     1440

ctctatgtgt ttgcagtaat tctttttttt tttttttttg agacggagtc tcgcactgtt     1500

gcccaggctg gagtgcagtg gcgtgatctt ggctcactgc aagctccgcc tcccgagttc     1560

aagcaattct cctgcctcag cctcccgagt agctgggatt acaggtgcct gccaccacac     1620

ccagctaacg ttttgtattt ttagtagaga tggggtttca ccatgttggc caggcagatc     1680

tcaaacttct gacctcgtga tgcactcacc tcggcctccc aaagtgctgg gattacaggc     1740

gtgagccact gcgccctgcc tgtttgtagt aatttttagg caccaaatct ccctcatctt     1800

ctagtgccat tctcctctct gttcaggtaa atgtcacact gtgcccagaa tggatgacca     1860

ggaaccttca agagtggctg aaaagattgc agagttatca taataaattg ctaacttgcg     1920

tatttccta                                                             1929


<210> 2399
<211> 2023
<212> DNA
<213> Homo sapiens

<400> 2399
gatcagccac agaagttaaa cttctttcca gggaagaagg gcggggatgt cagggctgga       60

gagtgcccgt gtccttctgt gtgcattggg ctccttcctc cttaattctc tgctttccac      120

ttttaggctg aactccagtg cacccagtta gacttggagc ggaaactcaa gttgaatgaa      180

aatgccatct ccaggctcca ggctaaccaa aagtctgttc tggctccttg aatgtattga      240

ggcctctcct ctctgtacta tttctgcttg tcatcatttt cgtggtgtcg gtgtcagagg      300

tcaaagcagt ggctgaaatg cagtttgggg aactccttgc tgctgtgagg aaggcccagg      360

ccaatgtgat gctcttctta gaggagaagg agcaagctgc gctgagccag gccaacggta      420

tcaaggccca cctggagtac aggagtgccg agatggagaa gagtaagcag gagctggaga      480

cgatggcggc catcagcaac actgtccagt tcttggagga gtactgcaag tttaagaaca      540

ctgaagacat caccttccct agtgtttaca tagggctgaa ggataaactc tcgggcatcc      600

gcaaagttat cacggaatcc actgtacact taatccagtt gctggagaac tataagaaaa      660

agctccagga gttttccaag gaagaggagt atgacatcag aactcaagtg tctgccattg      720

ttcagcgcaa atattggact tccaaacctg agcccagcac cagggaacag ttcctccaat      780

atgtgcatga catcacgttc gacccggaca cagcacacaa gtatctccgg ctgcaggagg      840

agaaccgcaa ggtcaccaac accacgccct gggagcatcc ctacccggac ctccccagca      900

ggttcctgca ctggcggcag gtgctgtccc agcagagtct gtacctgcac aggtactatt      960

ttgaggtgga gatcttcggg gcaggcacct atgttggcct gacctgcaaa ggcatcgacc     1020

agaaagggga ggagcgcagc agttgcattt ccggaaacaa cttctcctgg agcctccaat     1080

ggaacgggaa ggagttcacg gcctggtaca gtgacatgga gaccccactc aaagctggcc     1140

ctttctggag gctcggggtc tatattgact tcccaggagg gatcctttcc ttctatggcg     1200

tagagtatga ttccatgact ctggttcaca agtttgcctg caagttttca gaaccagtct     1260

atgctgcctt ctggctttcc aagaaggaaa acgccatccg gattgtagat ctgggagagg     1320

aacccgagaa gccagcaccg tccttggtgg ggactgctcc ctagactcca ggagccatat     1380

cccagacctt tgccagctac agtgatggga tttgcatttt agggtgattt gggggcaaaa     1440

ataactgctg atggtagctg gcttttgaaa tcctatgggg tctctgaatg aaaacattct     1500

ccagctgctc tcttttgctc catatggtgc tgttctctat gtgtttgcag taattctttt     1560

tttttttttt tttgagacgg agtctcgcac tgttgcccag gctggagtgc agtggcgtga     1620

tcttggctca ctgcaagctc cgcctcccga gttcaagcaa ttctcctgcc tcagcctccc     1680

gagtagctgg gattacaggt gcctgccacc acacccagct aacgttttgt atttttagta     1740

gagatggggt ttcaccatgt tggccaggca gatctcaaac ttctgacctc gtgatgcact     1800

cacctcggcc tcccaaagtg ctgggattac aggcgtgagc cactgcgccc tgcctgtttg     1860

tagtaatttt taggcaccaa atctccctca tcttctagtg ccattctcct ctctgttcag     1920

gtaaatgtca cactgtgccc agaatggatg accaggaacc ttcaagagtg gctgaaaaga     1980

ttgcagagtt atcataataa attgctaact tgcgtatttc cta                       2023


<210> 2400
<211> 790
<212> DNA
<213> Homo sapiens

<400> 2400
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgatgattca acacgcgttc ctcttggaaa aagcaaggac tacatcaatg ctagttatat      120

tagaatagtc aattgtggag aagagtattt ttatatcgct actcaaggac cactgctgag      180

caccatagat gacttttggc aaatggtgtt ggaaaataat tcaaatgtta ttgccatgat      240

aaccagagag atagaaggtg gaattatcaa atgctaccat tactggccca tttctctgaa      300

gaagccattg gaattgaaac acttccgtgt attcctggag aactaccaga tacttcaata      360

tttcatcatt cgaatgtttc aagttgtgga gaagtccacg ggaactagtc actctgtaaa      420

acagttgcag ttcaccaagt ggccagacca tggcactcct gcctcagcag atagcttcat      480

aaaatatatt cgttatgcaa ggaagagcca ccttacagga cccatggttg ttcactgcag      540

tgccggcata ggccggacag gggtgttcct atgtgtggat gtcgtgttct gtgccatcgt      600

aaagaactgt tcattcaaca tcatggatat agtggcccaa atgagagaac aacgttctgg      660

catggttcaa acgaaggagc agtatcactt ttgttacgat attgtgcttg aagttcttcg      720

gaaacttctg actttggatt aagaaagact tctgttgcct ctcacttgaa attaccaagt      780

gggtttgcac                                                             790


<210> 2401
<211> 4217
<212> DNA
<213> Homo sapiens

<400> 2401
gagcccggga gccggaggtg tagcggcaga gacattgttc ttgccggctc cctacggtgc       60

cgtgtgtgcg tgagagaaga ccagtctttc ctctagcatt tgacattgtg cagcaaagaa      120

atggttatgg agaagcccag tccgctgctt gtagggcggg agtttgtgag gcaatattat      180

actttgctga ataaagctcc ggaatattta cacaggtttt atggcaggaa ttcttcctat      240

gttcatggtg gagtagatgc tagtggaaag ccccaggaag ctgtttatgg ccaaaatgat      300

atacaccaca aagtattatc tctgaacttc agtgaatgtc atactaaaat tcgtcatgtg      360

gatgctcatg caaccttgag tgatggagta gttgtccagg tcatgggttt gctgtctaac      420

agtggacaac cagaaagaaa gtttatgcaa acctttgttc tggctcctga aggatctgtt      480

ccaaataaat tttatgttca caatgatatg tttcgttatg aagatgaagt gtttggtgat      540

tctgagcctg aacttgatga agaatcagaa gatgaagtag aagaggaaca agaagaaaga      600

caaccatctc ctgaacctgt gcaagaaaat gctaacagtg gttactatga agctcaccct      660

gtgactaatg gcatagagga gcctttggaa gaatcctctc atgaacctga acctgagcca      720

gaatctgaaa caaagactga agagctgaaa ccacaagtgg aggagaagaa cttagaagaa      780

ctagaggaga aatctactac tcctcctccg gcagaacctg tttctctgcc acaagaacca      840

ccaaaggctt tctcctgggc ttcagtgacc agtaaaaacc tgcctcctag tggtactgtt      900

tcttcctctg gaattccacc ccatgttaaa gcaccagtct cacagccaag agtcgaagct      960

aaaccagaag ttcaatctca gccacctcgt gtgcgtgaac aacgacctag agaacgacct     1020

ggttttcctc ctagaggacc aagaccaggc agaggagata tggaacagaa tgactctgac     1080

aaccgtagaa taattcgcta tccagatagt catcaacttt ttgttggtaa cttgccacat     1140

gatattgatg aaaatgagct aaaggaattc ttcatgagtt ttggaaacgt tgtggaactt     1200

cgcatcaata ccaagggtgt tgggggaaag cttccaaatt ttggttttgt ggtttttgat     1260

gactctgaac cagttcagag aatcttaatt gcaaaaccga ttatgtttcg aggggaagta     1320

cgtttaaatg tggaagagaa aaaaacaaga gctgcaagag agcgagaaac cagaggtggt     1380

ggtgatgatc gcagggatat taggcgcaat gatcgaggtc ccggtggtcc acgtggaatt     1440

gtgggtggtg gaatgatgcg tgatcgtgat ggaagaggac ctcctccaag gggtggcatg     1500

gcacagaaac ttggctctgg aagaggaacc gggcaaatgg agggccgctt cacaggacag     1560

cgtcgctgaa gctccactgt tggcaaagtc ttggcagtgg tacattattc atcgtgtttg     1620

cattcttgtt aatttttttt ttggctttgg aatgtgacac agcctttttg atcatttctt     1680

tgatgtgaaa agcatctttg gttatcagtt aaattgaggt ggacattatt tccccaattt     1740

cacaacagga ttcacattgt taatttataa atctagactt ggagaattaa ggactgagaa     1800

atgaccatat cttaaactat ctacgacaaa gtgaacttaa aaggacatgc ccactgaatt     1860

caggtccttt gagtaaaaaa aaaatcttct gctgcacatt ttgtttaagt gttactgttt     1920

ctgcctgtta atgctgggaa cacaaatagt gcaatttgtg caattggaga atcttgcctt     1980

ttttcttggc tccccccaaa aatacaaacc aacagaaact tgttatgcac tcatcaaaat     2040

gtactaatgg gtactctgaa ctcattaaca ttgacatctg caacaggagg caacagggaa     2100

aaaatctcat cttcttttcc agtagaaaat agtttgtgaa atgatgaggg cattttatct     2160

gcttgctgtg accagcgtgt gtacacataa accttaacaa gactacaagt atattccaga     2220

aggaaatcat tttagttatg aactaaataa taaaaattag aacttcaaat gcgatggtct     2280

tgactattag accagattta gtagctccat atctaagatt tttctacctg cccctcttca     2340

gtacagggat ggctggctgc tcaacacact cctcctcccc ttttttcctt tctttaagct     2400

gtgtacagtg aaaattgtct ttactgtatt tttgttctct ggtaatgtaa taagcatgat     2460

ggtgccttct attaatacat cattccagtc ttgctggtaa ttttgtacag tatagtgtat     2520

gaattgctgt gctgcaaagc caaacagctg caaaatgttg aaaaatcatc gaaatgtata     2580

aaaattgcag tatctttaaa atcagtaaaa tggactagca tattatttat cttgttcttc     2640

agttaacaac tttgtgttct ctgtgggagg gagggagtcc tgtgtgtttg tggggagagg     2700

gaaggaggaa gtcagttatt tgagtaagcc tctagttgac ttttctctta gcctgaatgt     2760

ggacgttgaa acatatcact tcagggcttg gaaaagtcag tcaacttgac gtacattttt     2820

agtgacattt taaaagcagt cagattctat aaatggcaag taagcctgaa gtgaggatac     2880

tgcaattttc ggagaaaaga acagcagctc tttaagtgtt tgcattttct atttgggggg     2940

cagggaactg tcattcattt tgcacaattc ttgaactgat gtcagcaccc gagtggctcc     3000

tgaatttaag tctgggacga catcttttat ttttacatga atctttaaac aattctgtga     3060

gcaaagtttg tagctgctgg attattgtct gtctttatag caagttccag taaaccacaa     3120

gtatggcaaa gcttatccaa ttttatgctt ggagcagtca gtacatacca gtttctgatg     3180

tttcaggcag gagtggggta aataagtgtg accacttaaa gctgctcgtt agcatggaag     3240

acttctccat tctatctttg taaaacagac aagatatgca cttgacatag tagcaaattg     3300

gttctgaatt atgcaactgt ttgctattta gtaaactagc aaatgatgca tgtattttgt     3360

ttttcatgta ctgggcaata tgagtaaaat ctgtcccttt ttcccccttt gaatgaggtc     3420

ttccatgttt gagggaaagt cttgcactat tgcatatatt ttggggacac agattttcat     3480

agtttccatt tttggggggc ttaaggattt tttttttttc tgtttgaaac agttttatac     3540

tttctgatat agtacttgaa attcttacca gaaaattact ttggagtttt gaagccttta     3600

ttaatactac ttttaaagaa gcagttgttt tattgtcaat gttttttttc ccccaagcat     3660

attttcttgt atttctgttt ccatatatat atatatatat ataatttcca attcaggata     3720

ttgccctgcc atccatgaaa actgttctgg caccaaaagt aatgacaaat gttaagtgta     3780

ataatagaaa agtagagcaa agagccattc agcttcagtc tttacatacc atgaataaaa     3840

cattaaaaca tcatatggag aagtttacat ggtgattgtt cacctgcagt actgtggagt     3900

tttaacattt tgtcctcttt tcagtgaaac agagtaaaaa tattcatcta ccattactgt     3960

tatttgctga ttttgtttta ttttttgatg gtaatattct atccttatga cactattgca     4020

accaaattgg ctttaccatc ttggctttag taggtataga agacaatgga ttaccatctt     4080

tattgctgta atgtgttaag cattatatgc tagtagaatc tagtttaatt gtttcaggtg     4140

gaaagtattc tttgagtttc catattgaat gtgtttggac taaacaaaca ataaactact     4200

gatgtctgca gcattta                                                    4217


<210> 2402
<211> 2779
<212> DNA
<213> Homo sapiens

<400> 2402
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc       60

ccaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc ggaatttccc      120

acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg atcccagcat      180

gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg aggaggctgc      240

agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg tttctgaagg      300

agaactagat cagttggctc agattcggcc attaatattc aattttcatg agcagacagc      360

catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata tcatgcagga      420

atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga atcaaccaag      480

caacagagaa aaaaacagat accgagatat tcttccatat gattcaacac gcgttcctct      540

tggaaaaagc aaggactaca tcaatgctag ttatattaga atagtcaatt gtggagaaga      600

gtatttttat atcgctactc aaggaccact gctgagcacc atagatgact tttggcaaat      660

ggtgttggaa aataattcaa atgttattgc catgataacc agagagatag aaggtggaat      720

tatcaaatgc taccattact ggcccatttc tctgaagaag ccattggaat tgaaacactt      780

ccgtgtattc ctggagaact accagatact tcaatatttc atcattcgaa tgtttcaagt      840

tgtggagaag tccacgggaa ctagtcactc tgtaaaacag ttgcagttca ccaagtggcc      900

agaccatggc actcctgcct cagcagatag cttcataaaa tatattcgtt atgcaaggaa      960

gagccacctt acaggaccca tggttgttca ctgcagtgcc ggcataggcc ggacaggggt     1020

gttcctatgt gtggatgtcg tgttctgtgc catcgtaaag aactgttcat tcaacatcat     1080

ggatatagtg gcccaaatga gagaacaacg ttctggcatg gttcaaacga aggagcagta     1140

tcacttttgt tacgatattg tgcttgaagt tcttcggaaa cttctgactt tggattaaga     1200

aagacttctg ttgcctctca cttgaaatta ccaagtgggt ttgcacctcc tcataaagaa     1260

catgtttgca ctgtgctgaa gggctttgct atgcatacaa tctgctttct tggtttatca     1320

gtttattttc tttctaaaag ctccctgaag ggcaatatca tttggcttgg ggtgatcagt     1380

gtttacttat tgatcttgct agacaatatc aaaataactt cccacatttt ccagtgaaac     1440

agatgttaca taaaacgatt gcagcttggc tatttggttg aagggattac agagcccaat     1500

aaaggattta aaatatattc attaagattt tatttggaaa ggtggctgga gagagctgag     1560

gatttccagg actttgtaag ttcttattct gggagaacat aaggccaata atcatgacct     1620

cttccaggca tttttaagac agatgtctat tcatgttctt tagctagagc ctgtactttt     1680

tgctggcatt tgaataaccc agtttaaaaa gagtccagtt agggtggact aactttggac     1740

acaaattggc ttccatttcc tacattttca tactgctgcc ttcctacagc tgctagacca     1800

agacctgttg gtctgggaag catttcatgg atagggagag ctcctctcgg tgaacagtcc     1860

aaaactaaaa tagatgttta tatagaaagc ccaagaggag atttttgcca tgcctgagtt     1920

ctttcctatc ccaccctaac acttaacata ttacttagtc tgctttgtta aaagcaagta     1980

ttacctttaa cttgcctctt actctttgcc ctttagctaa ctaataaagt ttgatatagg     2040

cattattata taattctgag tcattcatgg tatatctcat gtttgatgta tttttcaaac     2100

taagatctat gatagttttt tttccagagt tccattaaat catttatttc ctttactttc     2160

tcacctctgt tgaaacattt agaaactgga tttgggaacc caattttgga aaaccagatt     2220

catagtcatg aaaatggaaa cttccatatt ctgtttttga aaagatgtgg ccattattac     2280

agtaatttta ttataggact ttgcctcgta caattaatag tgatattttg gacaaggagt     2340

tctggtgaca agctatacct aattataagc tataaaacaa tagatatgag tgtttgtaca     2400

gtttaactca atggagatca gaatattcta tgtattgaga aaatgtttaa tatcaatcta     2460

taaatcttga atttctaaga ggcttatttt gttcttttgg ctgaatgagt atatttgaat     2520

tggttgaata attaataatt ctcattgtaa aaataattat atgccaaaaa tatatttgat     2580

gttaaatcaa atagatgatt ctgtttacat tgttcatatg aataataatc tgtgttaatt     2640

tcattttgat aattggcctt taatatttgt atctctaatt ttattttctc tctgttactg     2700

taaaataata gctataatgt ataacaattt tcttcagaag aattctatgc tattattaaa     2760

ataaaatatt tactgtgta                                                  2779


<210> 2403
<211> 2323
<212> DNA
<213> Homo sapiens

<400> 2403
gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc ctgactcaca       60

ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg ggatgggaac      120

aacatgtctt cacctaggga ctttagagca gagcctgtaa acgattatga gggaaatgac      180

tctgaagcag aagacttgaa tttcagggag actttgcctt catcaagtca ggaaaacaca      240

cctagatcaa aggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg      300

aatttcccac ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat      360

cccagcatgt ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag      420

gaggctgcag ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt      480

tctgaaggag aactagatca gttggctcag attcggccat taatattcaa ttttcatgag      540

cagacagcca tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc      600

atgcaggaat ttatgttcaa catcatggat atagtggccc aaatgagaga acaacgttct      660

ggcatggttc aaacgaagga gcagtatcac ttttgttacg atattgtgct tgaagttctt      720

cggaaacttc tgactttgga ttaagaaaga cttctgttgc ctctcacttg aaattaccaa      780

gtgggtttgc acctcctcat aaagaacatg tttgcactgt gctgaagggc tttgctatgc      840

atacaatctg ctttcttggt ttatcagttt attttctttc taaaagctcc ctgaagggca      900

atatcatttg gcttggggtg atcagtgttt acttattgat cttgctagac aatatcaaaa      960

taacttccca cattttccag tgaaacagat gttacataaa acgattgcag cttggctatt     1020

tggttgaagg gattacagag cccaataaag gatttaaaat atattcatta agattttatt     1080

tggaaaggtg gctggagaga gctgaggatt tccaggactt tgtaagttct tattctggga     1140

gaacataagg ccaataatca tgacctcttc caggcatttt taagacagat gtctattcat     1200

gttctttagc tagagcctgt actttttgct ggcatttgaa taacccagtt taaaaagagt     1260

ccagttaggg tggactaact ttggacacaa attggcttcc atttcctaca ttttcatact     1320

gctgccttcc tacagctgct agaccaagac ctgttggtct gggaagcatt tcatggatag     1380

ggagagctcc tctcggtgaa cagtccaaaa ctaaaataga tgtttatata gaaagcccaa     1440

gaggagattt ttgccatgcc tgagttcttt cctatcccac cctaacactt aacatattac     1500

ttagtctgct ttgttaaaag caagtattac ctttaacttg cctcttactc tttgcccttt     1560

agctaactaa taaagtttga tataggcatt attatataat tctgagtcat tcatggtata     1620

tctcatgttt gatgtatttt tcaaactaag atctatgata gttttttttc cagagttcca     1680

ttaaatcatt tatttccttt actttctcac ctctgttgaa acatttagaa actggatttg     1740

ggaacccaat tttggaaaac cagattcata gtcatgaaaa tggaaacttc catattctgt     1800

ttttgaaaag atgtggccat tattacagta attttattat aggactttgc ctcgtacaat     1860

taatagtgat attttggaca aggagttctg gtgacaagct atacctaatt ataagctata     1920

aaacaataga tatgagtgtt tgtacagttt aactcaatgg agatcagaat attctatgta     1980

ttgagaaaat gtttaatatc aatctataaa tcttgaattt ctaagaggct tattttgttc     2040

ttttggctga atgagtatat ttgaattggt tgaataatta ataattctca ttgtaaaaat     2100

aattatatgc caaaaatata tttgatgtta aatcaaatag atgattctgt ttacattgtt     2160

catatgaata ataatctgtg ttaatttcat tttgataatt ggcctttaat atttgtatct     2220

ctaattttat tttctctctg ttactgtaaa ataatagcta taatgtataa caattttctt     2280

cagaagaatt ctatgctatt attaaaataa aatatttact gtg                       2323


<210> 2404
<211> 2226
<212> DNA
<213> Homo sapiens

<400> 2404
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc       60

ccaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc ggaatttccc      120

acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg atcccagcat      180

gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg aggaggctgc      240

agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg tttctgaagg      300

agaactagat cagttggctc agattcggcc attaatattc aattttcatg agcagacagc      360

catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata tcatgcagga      420

atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga atcaaccaag      480

caacagagaa aaaaacagat accgagatat tcttccattt caacatcatg gatatagtgg      540

cccaaatgag agaacaacgt tctggcatgg ttcaaacgaa ggagcagtat cacttttgtt      600

acgatattgt gcttgaagtt cttcggaaac ttctgacttt ggattaagaa agacttctgt      660

tgcctctcac ttgaaattac caagtgggtt tgcacctcct cataaagaac atgtttgcac      720

tgtgctgaag ggctttgcta tgcatacaat ctgctttctt ggtttatcag tttattttct      780

ttctaaaagc tccctgaagg gcaatatcat ttggcttggg gtgatcagtg tttacttatt      840

gatcttgcta gacaatatca aaataacttc ccacattttc cagtgaaaca gatgttacat      900

aaaacgattg cagcttggct atttggttga agggattaca gagcccaata aaggatttaa      960

aatatattca ttaagatttt atttggaaag gtggctggag agagctgagg atttccagga     1020

ctttgtaagt tcttattctg ggagaacata aggccaataa tcatgacctc ttccaggcat     1080

ttttaagaca gatgtctatt catgttcttt agctagagcc tgtacttttt gctggcattt     1140

gaataaccca gtttaaaaag agtccagtta gggtggacta actttggaca caaattggct     1200

tccatttcct acattttcat actgctgcct tcctacagct gctagaccaa gacctgttgg     1260

tctgggaagc atttcatgga tagggagagc tcctctcggt gaacagtcca aaactaaaat     1320

agatgtttat atagaaagcc caagaggaga tttttgccat gcctgagttc tttcctatcc     1380

caccctaaca cttaacatat tacttagtct gctttgttaa aagcaagtat tacctttaac     1440

ttgcctctta ctctttgccc tttagctaac taataaagtt tgatataggc attattatat     1500

aattctgagt cattcatggt atatctcatg tttgatgtat ttttcaaact aagatctatg     1560

atagtttttt ttccagagtt ccattaaatc atttatttcc tttactttct cacctctgtt     1620

gaaacattta gaaactggat ttgggaaccc aattttggaa aaccagattc atagtcatga     1680

aaatggaaac ttccatattc tgtttttgaa aagatgtggc cattattaca gtaattttat     1740

tataggactt tgcctcgtac aattaatagt gatattttgg acaaggagtt ctggtgacaa     1800

gctataccta attataagct ataaaacaat agatatgagt gtttgtacag tttaactcaa     1860

tggagatcag aatattctat gtattgagaa aatgtttaat atcaatctat aaatcttgaa     1920

tttctaagag gcttattttg ttcttttggc tgaatgagta tatttgaatt ggttgaataa     1980

ttaataattc tcattgtaaa aataattata tgccaaaaat atatttgatg ttaaatcaaa     2040

tagatgattc tgtttacatt gttcatatga ataataatct gtgttaattt cattttgata     2100

attggccttt aatatttgta tctctaattt tattttctct ctgttactgt aaaataatag     2160

ctataatgta taacaatttt cttcagaaga attctatgct attattaaaa taaaatattt     2220

actgtg                                                                2226


<210> 2405
<211> 790
<212> DNA
<213> Homo sapiens

<400> 2405
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgatgattca acacgcgttc ctcttggaaa aagcaaggac tacatcaatg ctagttatat      120

tagaatagtc aattgtggag aagagtattt ttatatcgct actcaaggac cactgctgag      180

caccatagat gacttttggc aaatggtgtt ggaaaataat tcaaatgtta ttgccatgat      240

aaccagagag atagaaggtg gaattatcaa atgctaccat tactggccca tttctctgaa      300

gaagccattg gaattgaaac acttccgtgt attcctggag aactaccaga tacttcaata      360

tttcatcatt cgaatgtttc aagttgtgga gaagtccacg ggaactagtc actctgtaaa      420

acagttgcag ttcaccaagt ggccagacca tggcactcct gcctcagcag atagcttcat      480

aaaatatatt cgttatgcaa ggaagagcca ccttacagga cccatggttg ttcactgcag      540

tgccggcata ggccggacag gggtgttcct atgtgtggat gtcgtgttct gtgccatcgt      600

aaagaactgt tcattcaaca tcatggatat agtggcccaa atgagagaac aacgttctgg      660

catggttcaa acgaaggagc agtatcactt ttgttacgat attgtgcttg aagttcttcg      720

gaaacttctg actttggatt aagaaagact tctgttgcct ctcacttgaa attaccaagt      780

gggtttgcac                                                             790


<210> 2406
<211> 3304
<212> DNA
<213> Homo sapiens

<400> 2406
cgccgccgcc attttggagc gatcggagtg ccgcccgcgg ccccgagtcg gtctcgagcc       60

gccggccggc cgtgccggtg tccgtaggcg ctgcgccctc ggccgggccc atgtgtgtgc      120

ggcccgcccg aggccgcccg ggctttgcct ccaccagcgc cctggcctcc gctcgggcct      180

ccacacgggc ctccgaagag ctgccgcgac gcccggcccg cagggcaggt aaagagatta      240

taaatcttcc actgaatgaa aaaaattttc ttaaagctgc atatactcca agaaaaaaac      300

cacaaatgtt tttctgtttt gcctgaatac atgatttaaa caagagattt ccacagaagc      360

tctgcggccg tcacgatgtt ctggaagttt gacttgaaca ccacgtccca tgttgacaag      420

ctgctggaca aggagcatgt gacgctgcag gagttaatgg atgaagatga catcttgcag      480

gagtgtaagg ctcagaacca gaagctgctg gacttcctgt gcaggcagca gtgcatggag      540

gagctggtga gcctcatcac acaggatccg cccctggaca tggaggagaa ggtccgcttc      600

aaatatccaa acacagcctg tgagcttctg acttgtgatg tgccgcagat cagcgaccgc      660

ctcggtgggg acgagagcct gctgagcctc ctgtacgact tcttggacca tgagccgcct      720

ctcaatcctc tgctcgccag ttttttcagc aagaccattg gcaatctcat tgcaagaaaa      780

accgaacagg tgattacgtt tttgaagaag aaggacaagt tcatcagcct ggtgttgaag      840

cacatcggca cctcagcgct tatggacctg ctgctgcgcc tggtcagctg tgtggagcca      900

gccgggctcc ggcaggacgt cctgcactgg ctgaatgaag agaaggtcat ccagaggctt      960

gtggagttga tccacccgag ccaggatgaa gataggcagt caaatgcttc tcagactctc     1020

tgtgacatag ttaggctggg cagagaccag ggcagtcagc tgcaagaggc tctggagcca     1080

gacccgctcc tcacagcgct ggagtccagg caggactgtg tggagcagct tctgaagaac     1140

atgtttgatg gagaccggac ggagagctgc ctcgtcagtg ggactcaggt gttactcacc     1200

ttgctggaaa ccaggcgggt tgggacagag ggcttggtgg actccttttc tcagggactg     1260

gaaaggtcat acgctgtcag cagcagcgta ctacacggca tcgagcctcg gctgaaggac     1320

ttccaccagc tcctgctcaa cccgcccaag aagaaagcga tcctgaccac cattggtgtg     1380

ctggaggagc ccctggggaa tgcccgtctg catggcgccc gcctcatggc agcactgctg     1440

cacacaaaca cacccagcat caaccaggag ctctgccggc tcaacacgat ggacttactg     1500

ctggacttgt tctttaagta cacctggaat aactttttgc acttccaagt ggaactatgc     1560

atagccgcta ttctctccca cgctgcccgt gaggagagga cagaagccag cggatccgag     1620

agcagggtgg agcctccgca tgagaacggg aaccggagcc tggagactcc ccagccggcc     1680

gccagcctcc ctgacaacac aatggtgacc cacctgttcc agaagtgctg cctggtgcag     1740

aggatcctgg aggcctggga agccaacgac cacacgcagg cagcgggtgg catgagacgt     1800

gggaacatgg gccacctcac acggatcgcc aacgcggtgg tgcagaacct ggagcggggc     1860

cctgtgcaga cgcacatcag cgaggtcatc cgagggctcc ctgcggactg ccgtggccgc     1920

tgggagagct tcgtggagga gacgctgacg gagacgaacc gcaggaacac tgtggacctg     1980

gccttctctg actaccagat ccagcagatg acagccaact tcgtggatca gtttggcttc     2040

aatgatgagg agtttgccga ccaggacgac aacatcaatg ccccgtttga caggatcgca     2100

gagatcaact tcaacatcga cgctgacgag gacagtccca gcgcagctct gtttgaggcc     2160

tgctgcagtg accgcatcca gccctttgat gatgatgagg acgaggacat ctgggaggac     2220

agtgacactc gctgtgctgc ccgggtgatg gccagaccca ggtttggagc cccccatgct     2280

tcagagagtt gctcaaagaa tggcccagag cgtggaggcc aggatgggaa ggcgagcttg     2340

gaagcacaca gagatgcacc tggggcaggt gccccaccgg cccccgggaa gaaggaagcg     2400

ccccctgtgg agggtgactc agaaggcgcc atgtggacgg cagtgtttga tgagccagcg     2460

aactcaacgc ccacagcccc aggagtggtg agggacgtgg gttccagtgt gtgggcagct     2520

ggcacctcag ctccagagga gaaaggctgg gccaagttca ctgacttcca acctttctgc     2580

tgctccgagt cagggcccag gtgcagctct ccggtggaca cagaatgcag ccatgctgag     2640

ggcagccgga gccaaggccc tgagaaagcc ttcagcccgg cttctccatg tgcctggaac     2700

gtgtgtgtca ccaggaaggc ccccctgctg gcctctgaca gtagctcctc tgggggctcc     2760

cacagcgagg atggcgacca gaaggcagcg agtgccatgg atgcggtgag caggggtccc     2820

ggccgggagg cccccccgct gcccacagtg gccaggacag aggaggctgt cggcagggtc     2880

gggtgtgctg acagccggct gttaagccct gcctgccccg cgccaaagga agtgactgct     2940

gccccagccg tggctgtgcc ccccgaggct actgtggcca tcaccacagc actgagcaag     3000

gctggccccg ccatacccac cccagcagtc tcttctgcac tggccgtggc ggtcccccta     3060

gggcccatca tggcagtcac agcagcccca gccatggtgg ccaccctggg gacagtgaca     3120

aaggacggga agacagatgc cccgccagaa ggagctgcct taaatggccc agtgtgatgc     3180

tgctgccgcc cggccacggc ccaccctggt caggctgcct ccttaatcga gaaaactacc     3240

tggtgatgca atcttttttt tttttaattt aatttaattt taaaataaat gctgcattgg     3300

taaa                                                                  3304


<210> 2407
<211> 3293
<212> DNA
<213> Homo sapiens

<400> 2407
ccattttgga gcgatcggag tgccgcccgc ggccccgagt cggtctcgag ccgccggccg       60

gccgtgccgg tgtccgtagg cgctgcgccc tcggccgggc ccatgtgtgt gcggcccgcc      120

cgaggccgcc cgggctttgc ctccaccagc gccctggcct ccgctcgggc ctccacacgg      180

gcctccgaag agctgccgcg acgcccggcc cgcagggcag gtaaagagat tataaatctt      240

ccactgaatg aaaaaaattt tcttaaagct gcatatactc caagaaaaaa accacaaatg      300

tttttctgtt ttgcctgaat acatgattta aacaagagat ttccacagaa gctctgcggc      360

cgtcacgatg ttctggaagt ttgacttgaa caccacgtcc catgttgaca agctgctgga      420

caaggagcat gtgacgctgc aggagttaat ggatgaagat gacatcttgc aggagtgtaa      480

ggctcagaac cagaagctgc tggacttcct gtgcaggcag cagtgcatgg aggagctggt      540

gagcctcatc acacaggatc cgcccctgga catggaggag aaggtccgct tcaaatatcc      600

aaacacagcc tgtgagcttc tgacttgtga tgtgccgcag atcagcgacc gcctcggtgg      660

ggacgagagc ctgctgagcc tcctgtacga cttcttggac catgagccgc ctctcaatcc      720

tctgctcgcc agttttttca gcaagaccat tggcaatctc attgcaagaa aaaccgaaca      780

ggtgattacg tttttgaaga agaaggacaa gttcatcagc ctggtgttga agcacatcgg      840

cacctcagcg cttatggacc tgctgctgcg cctggtcagc tgtgtggagc cagccgggct      900

ccggcaggac gtcctgcact ggctgaatga agagaaggtc atccagaggc ttgtggagtt      960

gatccacccg agccaggatg aagataggca gtcaaatgct tctcagactc tctgtgacat     1020

agttaggctg ggcagagacc agggcagtca gctgcaagag gctctggagc cagacccgct     1080

cctcacagcg ctggagtcgc aggactgtgt ggagcagctt ctgaagaaca tgtttgatgg     1140

agaccggacg gagagctgcc tcgtcagtgg gactcaggtg ttactcacct tgctggaaac     1200

caggcgggtt gggacagagg gcttggtgga ctccttttct cagggactgg aaaggtcata     1260

cgctgtcagc agcagcgtac tacacggcat cgagcctcgg ctgaaggact tccaccagct     1320

cctgctcaac ccgcccaaga agaaagcgat cctgaccacc attggtgtgc tggaggagcc     1380

cctggggaat gcccgtctgc atggcgcccg cctcatggca gcactgctgc acacaaacac     1440

acccagcatc aaccaggagc tctgccggct caacacgatg gacttactgc tggacttgtt     1500

ctttaagtac acctggaata actttttgca cttccaagtg gaactatgca tagccgctat     1560

tctctcccac gctgcccgtg aggagaggac agaagccagc ggatccgaga gcagggtgga     1620

gcctccgcat gagaacggga accggagcct ggagactccc cagccggccg ccagcctccc     1680

tgacaacaca atggtgaccc acctgttcca gaagtgctgc ctggtgcaga ggatcctgga     1740

ggcctgggaa gccaacgacc acacgcaggc agcgggtggc atgagacgtg ggaacatggg     1800

ccacctcaca cggatcgcca acgcggtggt gcagaacctg gagcggggcc ctgtgcagac     1860

gcacatcagc gaggtcatcc gagggctccc tgcggactgc cgtggccgct gggagagctt     1920

cgtggaggag acgctgacgg agacgaaccg caggaacact gtggacctgg ccttctctga     1980

ctaccagatc cagcagatga cagccaactt cgtggatcag tttggcttca atgatgagga     2040

gtttgccgac caggacgaca acatcaatgc cccgtttgac aggatcgcag agatcaactt     2100

caacatcgac gctgacgagg acagtcccag cgcagctctg tttgaggcct gctgcagtga     2160

ccgcatccag ccctttgatg atgatgagga cgaggacatc tgggaggaca gtgacactcg     2220

ctgtgctgcc cgggtgatgg ccagacccag gtttggagcc ccccatgctt cagagagttg     2280

ctcaaagaat ggcccagagc gtggaggcca ggatgggaag gcgagcttgg aagcacacag     2340

agatgcacct ggggcaggtg ccccaccggc ccccgggaag aaggaagcgc cccctgtgga     2400

gggtgactca gaaggcgcca tgtggacggc agtgtttgat gagccagcga actcaacgcc     2460

cacagcccca ggagtggtga gggacgtggg ttccagtgtg tgggcagctg gcacctcagc     2520

tccagaggag aaaggctggg ccaagttcac tgacttccaa cctttctgct gctccgagtc     2580

agggcccagg tgcagctctc cggtggacac agaatgcagc catgctgagg gcagccggag     2640

ccaaggccct gagaaagcct tcagcccggc ttctccatgt gcctggaacg tgtgtgtcac     2700

caggaaggcc cccctgctgg cctctgacag tagctcctct gggggctccc acagcgagga     2760

tggcgaccag aaggcagcga gtgccatgga tgcggtgagc aggggtcccg gccgggaggc     2820

ccccccgctg cccacagtgg ccaggacaga ggaggctgtc ggcagggtcg ggtgtgctga     2880

cagccggctg ttaagccctg cctgccccgc gccaaaggaa gtgactgctg ccccagccgt     2940

ggctgtgccc cccgaggcta ctgtggccat caccacagca ctgagcaagg ctggccccgc     3000

catacccacc ccagcagtct cttctgcact ggccgtggcg gtccccctag ggcccatcat     3060

ggcagtcaca gcagccccag ccatggtggc caccctgggg acagtgacaa aggacgggaa     3120

gacagatgcc ccgccagaag gagctgcctt aaatggccca gtgtgatgct gctgccgccc     3180

ggccacggcc caccctggtc aggctgcctc cttaatcgag aaaactacct ggtgatgcaa     3240

tctttttttt ttttaattta atttaatttt aaaataaatg ctgcattggt aaa            3293


<210> 2408
<211> 2055
<212> DNA
<213> Homo sapiens

<400> 2408
gccgcgaggg gccgccgtcc gtcccgcccc ctgccgggcc gcggcgctct gctagagcgt       60

ggctcagttt tggtagcggg accccggaaa tgtaaagcat gagcgggaac agtcgccagg      120

gcgagtgaca ggcgagccct atgctttact tccgagggcg gtgtcagcaa agctagagtc      180

agaggttccg gttgagatca agttgggaga cacacccttg ttcattctcc ttgagaagca      240

gctattatca acagaacatt gacagaacct gtgtttgggg aaaggactga tggctttgag      300

tctaggttgg aaagcacaca ggaaccactg tggtctcctc ttgcaggctc tgcgaagcag      360

tggtcttctc ttgtttccct gtggccagtg tccctggaga ggagctggaa gctttttgga      420

ccctgagata aaggctttcc tggaggagaa cactgaagtc accagcagtg gtagcctcac      480

ccctgaaatc cagttgcggc ttttgacccc cagatgcaaa ttctggtggg agagagctga      540

cctgtggccc cacagtgatc cttactgggc aatctactgg ccaggaggcc aagccctgtc      600

taggtatctt ttggataatc ctgatgttgt cagaggaaaa tctgtattag atcttgggag      660

tggatgtgga gctacagcta ttgctgctaa gatgagtggg gcatcaagga tcttggccaa      720

tgacatagac cctattgcag gaatggctat tacactaaat tgtgaattga acagactgaa      780

tccttttcct attttaatcc aaaacatttt gaatttggaa caagataagt gggaccttgt      840

tgttcttggc gatatgtttt atgatgaaga ccttgcagat agtcttcatc agtggctgaa      900

gaagtgcttc tggacctata gaactcgagt actgattggt gaccctgggc ggccccagtt      960

cagtggacac agcattcagc atcacctgca caaagtggta gaatattcac ttttggagtc     1020

tactaggcag gaaaacagtg gactgacaac aagcacagtg tggggttttc agccttgagt     1080

tgtcaaagtg cttccaagta tgaatatagt aatgtttgga tctgactcta aaagttttct     1140

ctataggaga tactctccag tttaatgaat gtaattcttg ttaaatggaa aatcttgttt     1200

ttaaaatatg aaggtttaga gttttgttta cttttgtcat gtaactggtt ctgtatttct     1260

atgcatgcca attatacaca tctctatctg catttttttt tctattttaa ccgctgaagg     1320

aatatgatta tacaatgcca tactcaatgg tggcagcatt taatttaagt aatggagaag     1380

aattaaacat tgtagctgga tctgtttctg tagtcgagga caactgtgat gtaactttga     1440

attaaacaaa caaaacaaaa cagaagaaga ctatatatat attttttctt tttttagaga     1500

cagtctcact ttgctcccag gctggaatgc agtggctatt cagaggctta atcattgggc     1560

actgcagcct tgaactctgg gctttttttt ttttttgaga tggagtctca gctctgtcgt     1620

ccaggctgga gtgcagtgac tcatgtctcg gctcactgta gcctccacct cccccaatca     1680

agcgattgtc ctgtctcagc ctccagagta gctgggattt taggtgtgca ccaccatgcc     1740

tggctaattt ttgtattttt agtagagacg gggttttgcc atgttggcca ggccggtctc     1800

aaactcctga cctcaggtga tccacccgcc ttggcctccc aaagtgctag gattacaggt     1860

gtgagccacc acgccagcct gacgatgttt tttacttcta tcacttcctt ttgatttttt     1920

cttatagctt ctatctctgc ttacgtcacc catcattctt gcgtgttgta tgcttttcgc     1980

attagagccc tttgcatgtt aatcagttat tttaaattta tgatctggta attctaaaat     2040

gtctgccata actga                                                      2055


<210> 2409
<211> 4156
<212> DNA
<213> Homo sapiens

<400> 2409
tagggcacgg gaagggctcg ctagaatgag ctcttaaact ggttgggtgt aagcggtttt       60

gggctagtct aaaccaaaca actgagaata aacgcggggt tcctgcaggt tgagagagta      120

cctgtctgca aatgtccagt agtgatggat tgccttgtag gccccagagc aatcggggaa      180

gttagcattc ttgttcaaga agctgctggt tcacttagag ctataaaaga atgttgtgag      240

tttggatttt cttccaaacg ttcaggattg aggttagggc tggtggtgag ggatcatgta      300

aagaggtttg agtggctcag ccttaggtcc cggtgtggaa agcttattct tttggtgtca      360

tcacgtggcc gtgggaatta tttagaatgt gatctgccct catgagaaga aaggagctct      420

gaagccgttg cagttcttcc tccctatgtg gaaaatcgaa tttctggaaa catcctccgt      480

attgggagat tttgcctatg taaaggctat ccttattggc tagcggcact aattacttta      540

aaagtaggat ggaagtacaa gtatctcaag catcattggg tttcgagctc acttctgtgg      600

aaaagagttt aagggagtgg tctagacttt ccagggaagt tattgcctgg ctgtgtccct      660

ctagtcctaa ttttatactt aactttcccc cacctccttc agcctcatct gtttcaatgg      720

tgcaactctt ttcatcccct tttggttacc agtcaccttc aggccattca gaggaggaaa      780

gagaggggaa tatgaagtca gccaagcccc aagtgaacca cagtcagcat ggggaaagcc      840

agcgggcctt gagccccctg cagtctactc tgagttctgc tgcatctcct tcccaagcgt      900

atgagaccta tattgaaaat ggactcatat gccttaaaca caaaattaga aacatcgaga      960

aaaagaagct caaactggag gattataagg atcgcctgaa aagtggagag catcttaatc     1020

cagaccagtt ggaagctgta gagaaatatg aagaagtgct acataatttg gaatttgcca     1080

aggagcttca aaaaaccttt tctgggttga gcctagatct actaaaagcg caaaagaagg     1140

cccagagaag ggagcacatg ctaaaacttg aggctgagaa gaaaaagctt cgaactatac     1200

ttcaagttca gtatgtattg cagaacttga cacaggagca cgtacaaaaa gacttcaaag     1260

ggggtttgaa tggtgcagtg tatttgcctt caaaagaact tgactacctc attaagtttt     1320

caaaactgac ctgccctgaa agaaatgaaa gtctgagtgt tgaagaccag atggagcagt     1380

catccttgta cttttgggac cttttggaag gtagtgagaa agcagtggta ggaacgacat     1440

acaaacactt gaaggatcta ctgtctaaat tgctgaactc aggctatttt gaaagtatcc     1500

cagttcccaa aaatgccaag gaaaaggaag taccactgga ggaagaaatg ctaatacaat     1560

cagagaaaaa aacacaatta tcgaagactg aatctgtcaa agagtcagag tctctaatgg     1620

aatttgccca gccagagata caaccacaag agtttcttaa cagacgctat atgacagaag     1680

tagattattc aaacaaacaa ggcgaagagc aaccttggga agcagattat gctagaaaac     1740

caaatctccc aaaacgttgg gatatgctta ctgaaccaga tggtcaagag aagaaacagg     1800

agtcctttaa gtcctgggag gcttctggta agcaccagga ggtatccaag cctgcagttt     1860

ccttagaaca gaggaaacaa gacacctcaa aactcaggtc tactctgccg gaagagcaga     1920

agaagcagga gatctccaaa tccaagccat ctcctagcca gtggaagcaa gatacaccta     1980

aatccaaagc agggtatgtt caagaggaac aaaagaaaca ggagacacca aagctgtggc     2040

cagttcagct gcagaaagaa caagatccaa agaagcaaac tccaaagtct tggacacctt     2100

ccatgcagag cgaacagaac accaccaagt catggaccac tcccatgtgt gaagaacagg     2160

attcaaaaca gccagagact ccaaaatcct gggaaaacaa tgttgagagt caaaaacact     2220

ctttaacatc acagtcacag atttctccaa agtcctgggg agtagctaca gcaagcctca     2280

taccaaatga ccagctgctg cccaggaagt tgaacacaga acccaaagat gtgcctaagc     2340

ctgtgcatca gcctgtaggt tcttcctcta cccttccgaa ggatccagta ttgaggaaag     2400

aaaaactgca ggatctgatg actcagattc aaggaacttg taactttatg caagagtctg     2460

ttcttgactt tgacaaacct tcaagtgcaa ttccaacgtc acaaccgcct tcagctactc     2520

caggtagccc cgtagcatct aaagaacaaa atctgtccag tcaaagtgat tttcttcaag     2580

agccgttaca ggcagcaatt cccccaggca agcaaccgtc ttcactagct tctccaaatc     2640

ctcccatggc aaagggctct gaacagggct tccagtcacc tccagcaagt agtagttcag     2700

taaccattaa cacagcaccc tttcaagcca tgcagacagt atttaacgtt aatgcacctc     2760

tgcctccacg aaaagaacaa gaaataaaag aatcccctta ttcacctggc tacaatcaaa     2820

gttttaccac agcaagtaca caaacaccac cccagtgcca actgccatct atacatgtag     2880

aacaaactgt ccattctcaa gagactgcac agacgaatgt gtttcccaga cctactcagc     2940

catttgtcaa tagccgggga tctgttagag gatgtactcg tggtgggaga ttaataacca     3000

attcctatcg gtcccctggt ggttataaag gttttgatac ttatagagga ctcccttcaa     3060

tttccaatgg aaattatagc cagctgcagt tccaagctag agagtattct ggagcacctt     3120

attcccaaag ggataatttc cagcagtgtt ataagcgagg agggacatct ggtggtccac     3180

gagcaaattc gagagctaac tgcttcatta tgagaaactc actgttgcta ataaaacagc     3240

agggtggagt gattcttctc aggtgagcag cccagaaaga gacaacgaaa cctttaacag     3300

tggtgactct ggacaaggag actcccgtag catgacccct gtggatgtgc cagtgacaaa     3360

tccagcagcc accatactgc cagtacacgt ctaccctctg cctcagcaga tgcgagttgc     3420

cttctcagca gccagaacct ctaatctggc ccctggaact ttagaccaac ctattgtgtt     3480

tgatcttctt ctgaacaact taggagaaac ttttgatctt cagcttggta gatttaattg     3540

cccagtgaat ggcacttacg ttttcatttt tcacatgcta aagctggcag tgaatgtgcc     3600

actgtatgtc aacctcatga agaatgaaga ggtcttggta tcagcctatg ccaatgatgg     3660

tgctccagac catgaaactg ctagcaatca tgcaattctt cagctcttcc agggagacca     3720

gatatggtta cgtctgcaca ggggagcaat ttatggaagt agctggaaat attctacgtt     3780

ttcaggctat cttctttatc aagattgaaa gtcagtacag tattgacaat aaaaggatgg     3840

tgttctaatt agtgggattg aaggaaaagt agtctttgcc ctcatgactg attggtttag     3900

gaaaatgttt ttgttcctag agggaggagg tccttacttt tttgttttcc ttcctgaggt     3960

gaaaaatcaa gctgaatgac aattagcact aatctggcac tttataaatt gtgatgtagc     4020

ctcgctagtc aagctgtgaa tgtatattgt ttgcacttaa tccttaactg tattaacgtt     4080

cagcttacta aactgactgc ctcaagtcca ggcaagttac aatgccttgt tgtgcctcaa     4140

taaaaaagtt acatgc                                                     4156


<210> 2410
<211> 2602
<212> DNA
<213> Homo sapiens

<400> 2410
gcttcgttac tgggccctgg aagcgaggtc agagctggaa atggccttag gggtcaccta       60

gggcctaatc catcgtttct cttgtggggg aactgagcct ctgggaaggg tcacattgcg      120

ttaatgcagt gtgtgtcgcc tctgtccctc ccccttacac gtctggcgtc tcgtcagata      180

catgtcagct cctgggagaa gctttccctg gccgctttgc agaagggcgt ccccttttag      240

cctcttccac gtcaacctgc tccatttctt tcgtagcagt taccagtctc tgaaactaag      300

tctgtttctg tcttagcccg ccaagtattt attgtatacg tatataggtg ccaccgtaca      360

ggcagtactt ctccaggttc aaaatgagcc tgtttggaac aacctcaggt tttggaacca      420

gtgggaccag catgtttggc agtgcaacta cagacaatca caatcccatg aaggatattg      480

aagtaacatc atctcctgat gatagcattg gttgtctgtc ttttagccca ccaaccttgc      540

cggggaactt tcttattgca ggatcatggg ctaatgatgt tcgctgctgg gaagttcaag      600

acagtggaca gaccattcca aaagcccagc agatgcacac tgggcctgtg cttgatgtct      660

gctggagtga cgatgggagc aaagtgttta cggcatcgtg tgataaaact gccaaaatgt      720

gggacctcag cagtaaccaa gcgatacaga tcgcacagca tgatgctcct gttaaaacca      780

tccattggat caaagctcca aactacagct gtgtgatgac tgggagctgg gataagactt      840

taaagttttg ggatactcga tcgtcaaatc ctatgatggt tttgcaactc cctgaaaggt      900

gttactgtgc tgacgtgata taccccatgg ctgtggtggc aactgcagag aggggcctga      960

ttgtctatca gctagagaat caaccttctg aattcaggag gatagaatct ccactgaaac     1020

atcagcatcg gtgtgtggct atttttaaag acaaacagaa caagcctact ggttttgccc     1080

tgggaagtat cgaggggaga gttgctattc actatatcaa ccccccgaac cccgccaaag     1140

ataacttcac ctttaaatgt catcgatcta atggaaccaa cacttcagct cctcaggaca     1200

tttatgcggt aaatggaatc gcgttccatc ctgttcatgg cacccttgca actgtgggat     1260

ctgatggtag attcagcttc tgggacaaag atgccagaac aaaactaaaa acttcggaac     1320

agttagatca gcccatctca gcttgctgtt tcaatcacaa tggaaacata tttgcatacg     1380

cttccagcta cgactggtca aagggacatg aattttataa tccccagaaa aaaaattaca     1440

ttttcctgcg taatgcagcc gaagagctaa agcccaggaa taagaagtag tggctggaga     1500

ctctggctca gccagagttg tttctctcca ctctgcctca tctctgtacg aatttgggtc     1560

ccagccttgt tgggttgtca gccatggaca tggatttcaa cccctggaga aaacgatgtc     1620

attgttcagc agctgagagc ccaggcgtcc gcggcgactt gccgtctctc cattccactg     1680

cctgttgcag agtttttctg taactaaggg ggttgaggtt attgtagacg ttagattgcg     1740

ggcaccgcca gggattttgc agcgcttcag tgtacgtgtt agagaatatt ggaaaagcgt     1800

ctgtgagccc cgtgctgtat tttgtaataa agtcttttgc agattgcttc ccgagcttcc     1860

tttgtccttt tctccccttg cccaccccgt aacctcagga acatgcgtcc tgcccagcat     1920

cagcgtgggg ttttgagttg agatttcaga caccctctgg gaaatgcggc aaccttaggg     1980

gaaagggagt ccccagctgc gctcacttct gctgcgcgga acggcagcct ctgtgagccc     2040

tggtgggcag agtttgaatg tgtttttcct tgcttccctc attcccatct tcaaaatccc     2100

cagtgctttc tggccttgct gctcagattt ccgagtgact caaatgggga ctgttacttg     2160

tgctgggtga caggccattt gtgggtaacc tcctaaggcc caagtgggtg acacttgcgt     2220

gactttcaag ttagaaccca agccccctgc atgggaattg ccctgaactc ttacccaccc     2280

cggtcccctg catgggaatt gccctgaacc ctcagtagtg gttgtttggc tgttcttttg     2340

tattttgtgt aatttaaaat tcctggttgg taagtattca aaatgaaatt cagctgggct     2400

gagaaaaagt gtgacttttg ggtctgtcac tgtatttctc acctgtgatc tcaaatgctt     2460

cttaggcctt tctgtttgga ctaatgtgtg aagtctgact tgctgagtgt aaaattctag     2520

tatcgatagt gttgtaagat gtgtttgcct actcataaaa aacaatgaaa ataaaatttt     2580

ctactggaag agaccacctg ca                                              2602


<210> 2411
<211> 2639
<212> DNA
<213> Homo sapiens

<400> 2411
gatcagcccg cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgcctgg       60

ccagttgcgg atttataaaa gcagtcgctt agtaacttgc agcggctaca tcaactttgg      120

accaattcgc aaactgctgg tgtaaagcgt ttttgcgcat gtgctgtcgc cttgcgggaa      180

aaggagcctt tttcttcgac gatttccggg cgacgcagga agtggctcca gggcgcacgc      240

gcgttgtttc cgcggtagtc agggcagttt ctaccgcagg cttaaggagg cttcgggctc      300

ctgggatttc tgtccgcgct cctggccctc gtccttcgcg ccagagcagg ttcgcaaact      360

cctcagaccc ttctgctccc ggccgccgct ttccgccggg gcgagacccc caggttcaaa      420

atgagcctgt ttggaacaac ctcaggtttt ggaaccagtg ggaccagcat gtttggcagt      480

gcaactacag acaatcacaa tcccatgaag gatattgaag taacatcatc tcctgatgat      540

agcattggtt gtctgtcttt tagcccacca accttgccgg ggaactttct tattgcagga      600

tcatgggcta atgatgttcg ctgctgggaa gttcaagaca gtggacagac cattccaaaa      660

gcccagcaga tgcacactgg gcctgtgctt gatgtctgct ggagtgacga tgggagcaaa      720

gtgtttacgg catcgtgtga taaaactgcc aaaatgtggg acctcagcag taaccaagcg      780

atacagatcg cacagcatga tgctcctgtt aaaaccatcc attggatcaa agctccaaac      840

tacagctgtg tgatgactgg gagctgggat aagactttaa agttttggga tactcgatcg      900

tcaaatccta tgatggtttt gcaactccct gaaaggtgtt actgtgctga cgtgatatac      960

cccatggctg tggtggcaac tgcagagagg ggcctgattg tctatcagct agagaatcaa     1020

ccttctgaat tcaggaggat agaatctcca ctgaaacatc agcatcggtg tgtggctatt     1080

tttaaagaca aacagaacaa gcctactggt tttgccctgg gaagtatcga ggggagagtt     1140

gctattcact atatcaaccc cccgaacccc gccaaagata acttcacctt taaatgtcat     1200

cgatctaatg gaaccaacac ttcagctcct caggacattt atgcggtaaa tggaatcgcg     1260

ttccatcctg ttcatggcac ccttgcaact gtgggatctg atggtagatt cagcttctgg     1320

gacaaagatg ccagaacaaa actaaaaact tcggaacagt tagatcagcc catctcagct     1380

tgctgtttca atcacaatgg aaacatattt gcatacgctt ccagctacga ctggtcaaag     1440

ggacatgaat tttataatcc ccagaaaaaa aattacattt tcctgcgtaa tgcagccgaa     1500

gagctaaagc ccaggaataa gaagtagtgg ctggagactc tggctcagcc agagttgttt     1560

ctctccactc tgcctcatct ctgtacgaat ttgggtccca gccttgttgg gttgtcagcc     1620

atggacatgg atttcaaccc ctggagaaaa cgatgtcatt gttcagcagc tgagagccca     1680

ggcgtccgcg gcgacttgcc gtctctccat tccactgcct gttgcagagt ttttctgtaa     1740

ctaagggggt tgaggttatt gtagacgtta gattgcgggc accgccaggg attttgcagc     1800

gcttcagtgt acgtgttaga gaatattgga aaagcgtctg tgagccccgt gctgtatttt     1860

gtaataaagt cttttgcaga ttgcttcccg agcttccttt gtccttttct ccccttgccc     1920

accccgtaac ctcaggaaca tgcgtcctgc ccagcatcag cgtggggttt tgagttgaga     1980

tttcagacac cctctgggaa atgcggcaac cttaggggaa agggagtccc cagctgcgct     2040

cacttctgct gcgcggaacg gcagcctctg tgagccctgg tgggcagagt ttgaatgtgt     2100

ttttccttgc ttccctcatt cccatcttca aaatccccag tgctttctgg ccttgctgct     2160

cagatttccg agtgactcaa atggggactg ttacttgtgc tgggtgacag gccatttgtg     2220

ggtaacctcc taaggcccaa gtgggtgaca cttgcgtgac tttcaagtta gaacccaagc     2280

cccctgcatg ggaattgccc tgaactctta cccaccccgg tcccctgcat gggaattgcc     2340

ctgaaccctc agtagtggtt gtttggctgt tcttttgtat tttgtgtaat ttaaaattcc     2400

tggttggtaa gtattcaaaa tgaaattcag ctgggctgag aaaaagtgtg acttttgggt     2460

ctgtcactgt atttctcacc tgtgatctca aatgcttctt aggcctttct gtttggacta     2520

atgtgtgaag tctgacttgc tgagtgtaaa attctagtat cgatagtgtt gtaagatgtg     2580

tttgcctact cataaaaaac aatgaaaata aaattttcta ctggaagaga ccacctgca      2639


<210> 2412
<211> 3106
<212> DNA
<213> Homo sapiens

<400> 2412
gtggtttcct agaaacatga ttgtttattg gcattgatct cacagtctgg tgaggacttc       60

tttactgata atgtcaagtt caggttatcc tcccaaccaa ggagcattca gcacagaaca      120

aagtcgttat cctcctcact ctgtccagta tacatttccc aacacccgcc accagcagga      180

tccagcattc ggaggcaaac atgaagctcc atcctctcca atttcggggc aaccatgtgg      240

agatgatcaa aatgcttcac cttcaaaact ctcaaaggaa gagttaatac agagtatgga      300

tcgtgtagat cgagaaattg caaaagtaga acagcagatc cttaaactga aaaagaaaca      360

acaacagctt gaagaagagg cagctaaacc tcctgagcct gagaagcccg tgtcccctcc      420

tcctgtggag cagaaacacc gcagtattgt ccaaattatt tatgatgaga atcggaaaaa      480

agcagaagaa gctcataaaa tttttgaagg tcttggccca aaagttgaac tgccactgta      540

taaccagcca tcagatacca aggtgtacca tgagaacatc aagacaaacc aggtgatgag      600

gaaaaaactc attttatttt ttaaaagaag aaatcatgca agaaaacaaa gggaacaaaa      660

aatctgccag cgttatgatc agctcatgga ggcatgggag aaaaaagtgg acagaataga      720

aaataatcct cggaggaaag ctaaagaaag caaaacaagg gaatactatg aaaagcagtt      780

tccagaaatt cgaaaacaaa gagaacagca agaaagattt cagcgagttg ggcagagggg      840

agctggtctt tcagccacca ttgctaggag tgagcatgag atttctgaaa ttattgatgg      900

gctctctgag caggagaata atgagaaaca aatgcggcag ctctctgtga ttccacctat      960

gatgtttgat gcagaacaaa gacgagtcaa gttcattaac atgaatgggc ttatggagga     1020

ccctatgaaa gtgtataaag ataggcagtt tatgaatgtt tggactgacc atgaaaagga     1080

gatctttaag gacaagttta tccagcatcc aaaaaacttt ggactaattg catcatactt     1140

ggagaggaag agtgttcctg attgtgtttt gtattactat ttaaccaaga aaaatgagaa     1200

ttataaagcc ctcgtcagaa ggaattatgg gaaacgcaga ggcagaaacc agcaaattgc     1260

tcgaccctcg caagaagaaa aagtagaaga aaaagaagag gataaagcag aaaaaacaga     1320

aaaaaaagaa gaagaaaaga aagatgaaga ggaaaaagat gaaaaagaag actccaaaga     1380

aaataccaag gaaaaggaca agatagatgg tacagcagaa gaaactgagg aaagagagca     1440

agccacaccc cgggggcgaa agactgccaa cagtcagggc cgccgtaagg gccggatcac     1500

caggtccatg acaaacgaag ctgcagctgc cagtgctgca gccgcagcgg ctactgaaga     1560

gcccccacca cctctgccac cgccaccaga acccatttct acagagcctg tggagacctc     1620

tcgatggaca gaagaagaaa tggaagttgc taaaaaaggt ctagtagaac atggtcgtaa     1680

ctgggcagca attgctaaaa tggtgggaac gaaaagtgaa gctcaatgta aaaacttcta     1740

ttttaactat aaaaggcgac acaatcttga caacctctta cagcagcata aacagaaaac     1800

ttcacgaaaa cctcgtgaag agcgagatgt gtctcaatgt gaaagtgtcg cttccactgt     1860

ttctgctcag gaggatgaag atattgaagc ctccaatgaa gaagaaaatc cagaagacag     1920

cgaaggtgca gaaaatagtt ctgatacaga aagtgctcct tctccttcac cagttgaagc     1980

tgtcaagccc agcgaggaca gtcctgaaaa tgctacttct cgaggaaaca cagaacctgc     2040

ggttgagctt gagcccacca cggaaactgc acccagtaca tctccctcct tagcagttcc     2100

aagtacaaaa ccagctgaag atgaaagtgt ggagacccag gtgaatgaca gcatcagtgc     2160

tgagacagca gagcagatgg atgtagatca gcaggagcac agtgctgaag agggttctgt     2220

ttgtgatccc ccacccgcta ccaaagctga ctctgtggac gttgaagtga gggtgccaga     2280

aaaccatgca tctaaagttg aaggtgataa taccaaagaa agagacttgg atagagccag     2340

tgagaaggtg gaacctagag atgaagattt ggtggtagct cagcaaataa atgcccaaag     2400

gcccgagccc cagtcagaca atgattccag tgccacgtgc agcgctgatg aggatgtgga     2460

tggagagcca gagaggcaga gaatgtttcc tatggactca aagccttcac tgttaaaccc     2520

cactggatct atactcgtct catctccgtt aaaaccaaat ccactggatc tgccacagct     2580

tcagcatcga gctgctgtta tcccaccaat ggtatcctgc accccatgta acataccaat     2640

tggaacccca gtgagcggct atgctctcta ccagcgacac attaaagcaa tgcatgagtc     2700

agcactcctg gaggagcagc ggcagagaca agaacagata gatttggaat gtagaagttc     2760

tacaagtcca tgtggcacat ccaagagtcc aaacagagag tgggaaggta ggtagataga     2820

gctatcacca agagaacttt tatgaaggga aataaagcta aacccaaaag cagtgtccat     2880

tgtgctttgt aagttgtcag cctcccaact gattattata tttgtcctaa cagacacagt     2940

tccttaaatt gaccttaaac tatgaagaaa tgttagtatt attaactact aaaggatgcc     3000

agtaacattt ttaatagcat tctagttaat gtgaattttc tgatattcat ctttgtgctg     3060

gaagacatta taaataaagt tatgctttat gttccgttca tctgaa                    3106


<210> 2413
<211> 7994
<212> DNA
<213> Homo sapiens

<400> 2413
gtggtttcct agaaacatga ttgtttattg gcattgatct cacagtctgg tgaggacttc       60

tttactgata atgtcaagtt caggttatcc tcccaaccaa ggagcattca gcacagaaca      120

aagtcgttat cctcctcact ctgtccagta tacatttccc aacacccgcc accagcagga      180

tccagcattc ggaggcaaac atgaagctcc atcctctcca atttcggggc aaccatgtgg      240

agatgatcaa aatgcttcac cttcaaaact ctcaaaggaa gagttaatac agagtatgga      300

tcgtgtagat cgagaaattg caaaagtaga acagcagatc cttaaactga aaaagaaaca      360

acaacagctt gaagaagagg cagctaaacc tcctgagcct gagaagcccg tgtcccctcc      420

tcctgtggag cagaaacacc gcagtattgt ccaaattatt tatgatgaga atcggaaaaa      480

agcagaagaa gctcataaaa tttttgaagg tcttggccca aaagttgaac tgccactgta      540

taaccagcca tcagatacca aggtgtacca tgagaacatc aagacaaacc aggtgatgag      600

gaaaaaactc attttatttt ttaaaagaag aaatcatgca agaaaacaaa gggaacaaaa      660

aatctgccag cgttatgatc agctcatgga ggcatgggag aaaaaagtgg acagaataga      720

aaataatcct cggaggaaag ctaaagaaag caaaacaagg gaatactatg aaaagcagtt      780

tccagaaatt cgaaaacaaa gagaacagca agaaagattt cagcgagttg ggcagagggg      840

agctggtctt tcagccacca ttgctaggag tgagcatgag atttctgaaa ttattgatgg      900

gctctctgag caggagaata atgagaaaca aatgcggcag ctctctgtga ttccacctat      960

gatgtttgat gcagaacaaa gacgagtcaa gttcattaac atgaatgggc ttatggagga     1020

ccctatgaaa gtgtataaag ataggcagtt tatgaatgtt tggactgacc atgaaaagga     1080

gatctttaag gacaagttta tccagcatcc aaaaaacttt ggactaattg catcatactt     1140

ggagaggaag agtgttcctg attgtgtttt gtattactat ttaaccaaga aaaatgagaa     1200

ttataaagcc ctcgtcagaa ggaattatgg gaaacgcaga ggcagaaacc agcaaattgc     1260

tcgaccctcg caagaagaaa aagtagaaga aaaagaagag gataaagcag aaaaaacaga     1320

aaaaaaagaa gaagaaaaga aagatgaaga ggaaaaagat gaaaaagaag actccaaaga     1380

aaataccaag gaaaaggaca agatagatgg tacagcagaa gaaactgagg aaagagagca     1440

agccacaccc cgggggcgaa agactgccaa cagtcagggc cgccgtaagg gccggatcac     1500

caggtccatg acaaacgaag ctgcagctgc cagtgctgca gccgcagcgg ctactgaaga     1560

gcccccacca cctctgccac cgccaccaga acccatttct acagagcctg tggagacctc     1620

tcgatggaca gaagaagaaa tggaagttgc taaaaaaggt ctagtagaac atggtcgtaa     1680

ctgggcagca attgctaaaa tggtgggaac gaaaagtgaa gctcaatgta aaaacttcta     1740

ttttaactat aaaaggcgac acaatcttga caacctctta cagcagcata aacagaaaac     1800

ttcacgaaaa cctcgtgaag agcgagatgt gtctcaatgt gaaagtgtcg cttccactgt     1860

ttctgctcag gaggatgaag atattgaagc ctccaatgaa gaagaaaatc cagaagacag     1920

cgaaggtgca gaaaatagtt ctgatacaga aagtgctcct tctccttcac cagttgaagc     1980

tgtcaagccc agcgaggaca gtcctgaaaa tgctacttct cgaggaaaca cagaacctgc     2040

ggttgagctt gagcccacca cggaaactgc acccagtaca tctccctcct tagcagttcc     2100

aagtacaaaa ccagctgaag atgaaagtgt ggagacccag gtgaatgaca gcatcagtgc     2160

tgagacagca gagcagatgg atgtagatca gcaggagcac agtgctgaag agggttctgt     2220

ttgtgatccc ccacccgcta ccaaagctga ctctgtggac gttgaagtga gggtgccaga     2280

aaaccatgca tctaaagttg aaggtgataa taccaaagaa agagacttgg atagagccag     2340

tgagaaggtg gaacctagag atgaagattt ggtggtagct cagcaaataa atgcccaaag     2400

gcccgagccc cagtcagaca atgattccag tgccacgtgc agcgctgatg aggatgtgga     2460

tggagagcca gagaggcaga gaatgtttcc tatggactca aagccttcac tgttaaaccc     2520

cactggatct atactcgtct catctccgtt aaaaccaaat ccactggatc tgccacagct     2580

tcagcatcga gctgctgtta tcccaccaat ggtatcctgc accccatgta acataccaat     2640

tggaacccca gtgagcggct atgctctcta ccagcgacac attaaagcaa tgcatgagtc     2700

agcactcctg gaggagcagc ggcagagaca agaacagata gatttggaat gtagaagttc     2760

tacaagtcca tgtggcacat ccaagagtcc aaacagagag tgggaagtcc ttcagcctgc     2820

tccacatcaa gtgataacta atctccctga aggcgttcgg cttccgacaa ctcgaccaac     2880

caggccaccg ccccctctca tcccgtcatc caaaaccaca gtggcttcag aaaaaccatc     2940

ttttataatg ggaggctcca tctcacaggg aacaccaggc acttatttga cttctcataa     3000

tcaggcttcc tacactcaag aaacacccaa gccgtcagtg ggatctatct ctcttggact     3060

gccacggcaa caggaatctg ccaaatcagc tactttgccc tacatcaagc aggaagaatt     3120

ttctccccga agccaaaact cacaacctga gggtctgttg gtcagggccc aacatgaagg     3180

tgtagtcaga ggtaccgcag gagccataca agaaggaagt ataactcggg gaactccaac     3240

cagcaaaatt tcagtggaga gcattccatc cctacggggc tctatcactc agggcacccc     3300

ggctctgccc cagactggca taccaacaga ggctttggtg aaggggtcca tttcgagaat     3360

gcccattgaa gacagcagtc ctgagaaagg cagagaggaa gctgcatcca aaggccatgt     3420

tatttatgaa ggcaaaagtg gacatatctt gtcatatgat aatattaaga atgcccgaga     3480

agggactagg agtccaagaa cagctcatga aatcagttta aagagaagct atgaatcagt     3540

ggaaggaaat ataaagcaag ggatgtcaat gagggagtct cctgtatcag caccgttaga     3600

ggggctgata tgccgagcat tacccagggg gagtcctcat tctgacctca aagaaaggac     3660

tgtattgtct ggctccataa tgcaggggac accaagagca acaactgaaa gctttgaaga     3720

tggccttaaa tatcccaaac aaattaaaag ggaaagtcct cccatacgag catttgaagg     3780

tgccattacc aaaggaaaac catatgatgg catcaccacc atcaaagaaa tggggcgttc     3840

cattcatgag attccaaggc aagatatttt aactcaggaa agtcggaaaa ctccagaagt     3900

ggtccagagc acacggccga taattgaggg ttccatttcc cagggcacac caataaagtt     3960

tgacaacaac tcaggtcaat ctgccatcaa acacaatgtc aaatccttaa tcacggggcc     4020

tagcaaacta tcccgtggaa tgcctccgct ggaaattgtg ccagagaaca taaaagtggt     4080

agaacgggga aaatatgagg atgtgaaagc aggcgagacc gtgcgttccc ggcacacgtc     4140

agtggtaagc tctggcccct ccgttcttag gtccacactg catgaagctc ccaaagcaca     4200

actgagccct gggatttatg atgacaccag tgcacggagg acccctgtga gttatcaaaa     4260

caccatgtcc agaggctcac ccatgatgaa cagaacttct gatgtttctt ctaacaagtc     4320

taccaatcat gaaaggaaat cgacactgac ccctacccag agggaaagta tcccagcgaa     4380

gtctccagtg cctggggtgg accctgtcgt gagccacagt ccgtttgatc cccatcacag     4440

aggcagcact gcaggcgagg tttatcggag ccacctgccc acgcacttgg atccagccat     4500

gccttttcac agggctttgg atcctgcggc tgcttacctg tttcagagac agctttcacc     4560

aactccaggt tacccaagtc agtatcagct ttacgcaatg gagaacacaa gacagacaat     4620

cttaaatgat tacattacct cacaacagat gcaagtgaac ttgcgtccag atgtggccag     4680

aggactctcc ccaagagagc agccactggg tctcccatac ccagcaacga gaggaatcat     4740

tgacctgacc aatatgcctc caacaatttt agtgcctcat ccagggggaa caagcactcc     4800

tcccatggac agaatcactt atattcctgg tacacagatt actttccctc ccaggccgta     4860

caactctgct tccatgtctc caggacaccc aacacacctt gcagctgctg caagtgctga     4920

gagggaacgg gaacgggagc gggagaagga gcgggagcgg gaacggattg ctgcagcttc     4980

ctccgacctc tacctgcggc caggctcaga acagcctggc cgacctggca gtcatggata     5040

tgttcgctcc ccttcccctt cagtaagaac tcaggagacc atgttgcaac agagacccag     5100

tgttttccaa ggaaccaatg gaaccagtgt aatcacacct ttggatccaa ctgctcagct     5160

acgaatcatg ccactgcctg ctgggggccc ttcaataagc caaggcctgc cagcctcccg     5220

ttacaacact gctgcggatg ccctggctgc tcttgtggat gctgcagctt ctgcacccca     5280

gatggatgtg tccaaaacaa aagagagtaa gcatgaagct gccaggttag aagaaaattt     5340

gagaagcagg tcagcagcag ttagtgaaca gcagcagcta gagcagaaaa ccctggaggt     5400

ggagaagaga tctgttcagt gtttatacac ttcttcagcc tttccaagtg gcaagcccca     5460

gcctcattct tcagtagttt attctgaggc tgggaaagat aaagggcctc ctccaaaatc     5520

cagatatgag gaagagctaa ggaccagagg gaagactacc attactgcag ctaacttcat     5580

agacgtgatc atcacccggc aaattgcctc ggacaaggat gcgagggaac gtggctctca     5640

aagttcagac tcttctagta gcttatcttc tcacaggtat gaaacaccta gcgatgctat     5700

tgaggtgata agtcctgcca gctcacctgc gccaccccag gagaaactgc agacctatca     5760

gccagaggtt gttaaggcaa atcaagcgga aaatgatcct accagacaat atgaaggacc     5820

attacatcac tatcgaccac agcaggaatc accatctccc caacaacagc tgcccccttc     5880

ttcacaggca gagggaatgg ggcaagtgcc caggacccat cggctgatca cacttgctga     5940

tcacatctgt caaattatca cacaagattt tgctagaaat caagtttcct cgcagactcc     6000

ccagcagcct cctacttcta cattccagaa ctcaccttct gctttggtat ctacacctgt     6060

gaggactaaa acatcaaacc gttacagccc agaatcccag gctcagtctg tccatcatca     6120

aagaccaggt tcaagggtct ctccagaaaa tcttgtggac aaatccaggg gaagtaggcc     6180

tggaaaatcc ccagagagga gtcacgtctc ttcggagccc tacgagccca tctccccacc     6240

ccaggttccg gttgtgcatg agaaacagga cagcttgctg ctcttgtctc agaggggcgc     6300

agagcctgca gagcagagga atgatgcccg ctcaccaggg agtataagct acttgccttc     6360

attcttcacc aagcttgaaa atacatcacc catggttaaa tcaaagaagc aggagatttt     6420

tcgtaagttg aactcctctg gtggaggtga ctctgatatg gcagctgctc agccaggaac     6480

tgagatcttt aatctgccag cagttactac gtcaggctca gttagctcta gaggccattc     6540

ttttgctgat cctgccagta atcttgggct ggaagacatt atcaggaagg ctctcatggg     6600

aagctttgat gacaaagttg aggatcatgg agttgtcatg tcccagccta tgggagtagt     6660

gcctggtact gccaacacct cagttgtgac cagtggtgag acacgaagag aggaagggga     6720

cccatcacct cattcaggag tttgcaaacc aaagctgatc agcaagtcaa acagcaggaa     6780

atctaagtct cctatacctg ggcaaggcta cttaggaacg gaacggccct cttcagtctc     6840

ctctgtacat tcagaagggg attaccatag gcagacgcca gggtgggcct gggaagacag     6900

gccctcttca acaggctcaa ctcagtttcc ttataaccct ctgactatgc ggatgctcag     6960

cagtactcca ccaacaccga ttgcatgtgc tccctctgcg gtgaaccaag cagctcctca     7020

ccaacagaac aggatctggg agcgagagcc tgccccactg ctctcagcac agtacgagac     7080

cctgtcggat agtgatgact gaactgcaca aagtgagggg aacagggtgc aggagaggga     7140

tctctagttt ttgtggttta atttttagta gcaggtcaaa aacctgccct cctgtgactt     7200

attccctgag acttttcagg agagccagcc cacagatgat gaagaaatga tggaagttca     7260

tttggagagt caaatgggaa aaaaacaaac aaaaaactgc ctttgataca ggcaattcag     7320

tggactataa taatagtgga gggttgagat gtagagtttt taaaaagtga acagttgctg     7380

ttcttacatc tgtaaagaaa accataatgt ctttaaatca ctcttctgta aatagatgac     7440

ctttttgcag tgtatatccc cttgctgtag tatctggtgt acttatgttc aaatcagcgc     7500

atcaactttg ggggtgattt ttaaaaatct ttttgtctat ctatcttttt aaccctagcc     7560

ttctaaacaa cctcatacag cccagttaca taatgttggc tgtcacgggc attgtacttt     7620

tatctgatat tgtttcctct aaattcagct ttccagtgat gtttaaaatc ttgtgaaaat     7680

gtttagattt ttaacacaga ccctgtcata aaatctgtac attagggtca aaaggtaaaa     7740

gtaacaaatt ctgccatatt gtaaatttcc agtgcaggct ttaatttttt tttttcatta     7800

gtagcactga aaaaatatta ctgcatgggt atgttctagt tcagtttata aagttttaaa     7860

ggcttatttg aggcatacct cactgttacg cacactggta atttaaccat gcccctaagt     7920

attccttttc tcctgcattt gatgcagccc aacaaagctt ttgttttgaa ataaatttga     7980

ctaccctgtc cata                                                       7994


<210> 2414
<211> 7950
<212> DNA
<213> Homo sapiens

<400> 2414
attggcattg atctcacagt ctggtgagga cttctttact gataatgtca agttcaggtt       60

atcctcccaa ccaaggagca ttcagcacag aacaaagtcg ttatcctcct cactctgtcc      120

agtatacatt tcccaacacc cgccaccagc aggagttcgc agtccctgat tatcgttcct      180

ctcatcttga agtgagtcag gcatcacagc ttttgcagca acagcagcag caacagcttc      240

gaaggcgacc ttccttgctt tcagaatttc acccaggttc tgacaggcct caagaaagga      300

gaactagtta tgaaccgttt catccaggcc catccccagt ggatcatgat tcactggaat      360

cgaagcgacc acgtctggaa caggtttctg attctcattt tcagcgtgtc agtgctgcgg      420

ttttgccttt agtgcacccg ctgccagaag ggctgagggc ttctgcagat gctaagaagg      480

atccagcatt cggaggcaaa catgaagctc catcctctcc aatttcgggg caaccatgtg      540

gagatgatca aaatgcttca ccttcaaaac tctcaaagga agagttaata cagagtatgg      600

atcgtgtaga tcgagaaatt gcaaaagtag aacagcagat ccttaaactg aaaaagaaac      660

aacaacagct tgaagaagag gcagctaaac ctcctgagcc tgagaagccc gtgtcccctc      720

ctcctgtgga gcagaaacac cgcagtattg tccaaattat ttatgatgag aatcggaaaa      780

aagcagaaga agctcataaa atttttgaag gtcttggccc aaaagttgaa ctgccactgt      840

ataaccagcc atcagatacc aaggtgtacc atgagaacat caagacaaac caggtgatga      900

ggaaaaaact cattttattt tttaaaagaa gaaatcatgc aagaaaacaa agggaacaaa      960

aaatctgcca gcgttatgat cagctcatgg aggcatggga gaaaaaagtg gacagaatag     1020

aaaataatcc tcggaggaaa gctaaagaaa gcaaaacaag ggaatactat gaaaagcagt     1080

ttccagaaat tcgaaaacaa agagaacagc aagaaagatt tcagcgagtt gggcagaggg     1140

gagctggtct ttcagccacc attgctagga gtgagcatga gatttctgaa attattgatg     1200

ggctctctga gcaggagaat aatgagaaac aaatgcggca gctctctgtg attccaccta     1260

tgatgtttga tgcagaacaa agacgagtca agttcattaa catgaatggg cttatggagg     1320

accctatgaa agtgtataaa gataggcagt ttatgaatgt ttggactgac catgaaaagg     1380

agatctttaa ggacaagttt atccagcatc caaaaaactt tggactaatt gcatcatact     1440

tggagaggaa gagtgttcct gattgtgttt tgtattacta tttaaccaag aaaaatgaga     1500

attataaagc cctcgtcaga aggaattatg ggaaacgcag aggcagaaac cagcaaattg     1560

ctcgaccctc gcaagaagaa aaagtagaag aaaaagaaga ggataaagca gaaaaaacag     1620

aaaaaaaaga agaagaaaag aaagatgaag aggaaaaaga tgaaaaagaa gactccaaag     1680

aaaataccaa ggaaaaggac aagatagatg gtacagcaga agaaactgag gaaagagagc     1740

aagccacacc ccgggggcga aagactgcca acagtcaggg ccgccgtaag ggccggatca     1800

ccaggtccat gacaaacgaa gctgcagctg ccagtgctgc agccgcagcg gctactgaag     1860

agcccccacc acctctgcca ccgccaccag aacccatttc tacagagcct gtggagacct     1920

ctcgatggac agaagaagaa atggaagttg ctaaaaaagg tctagtagaa catggtcgta     1980

actgggcagc aattgctaaa atggtgggaa cgaaaagtga agctcaatgt aaaaacttct     2040

attttaacta taaaaggcga cacaatcttg acaacctctt acagcagcat aaacagaaaa     2100

cttcacgaaa acctcgtgaa gagcgagatg tgtctcaatg tgaaagtgtc gcttccactg     2160

tttctgctca ggaggatgaa gatattgaag cctccaatga agaagaaaat ccagaagaca     2220

gcgaaggtgc agaaaatagt tctgatacag aaagtgctcc ttctccttca ccagttgaag     2280

ctgtcaagcc cagcgaggac agtcctgaaa atgctacttc tcgaggaaac acagaacctg     2340

cggttgagct tgagcccacc acggaaactg cacccagtac atctccctcc ttagcagttc     2400

caagtacaaa accagctgaa gatgaaagtg tggagaccca ggtgaatgac agcatcagtg     2460

ctgagacagc agagcagatg gatgtagatc agcaggagca cagtgctgaa gagggttctg     2520

tttgtgatcc cccacccgct accaaagctg actctgtgga cgttgaagtg agggtgccag     2580

aaaaccatgc atctaaagtt gaaggtgata ataccaaaga aagagacttg gatagagcca     2640

gtgagaaggt ggaacctaga gatgaagatt tggtggtagc tcagcaaata aatgcccaaa     2700

ggcccgagcc ccagtcagac aatgattcca gtgccacgtg cagcgctgat gaggatgtgg     2760

atggagagcc agagaggcag agaatgtttc ctatggactc aaagccttca ctgttaaacc     2820

ccactggatc tatactcgtc tcatctccgt taaaaccaaa tccactggat ctgccacagc     2880

ttcagcatcg agctgctgtt atcccaccaa tggtatcctg caccccatgt aacataccaa     2940

ttggaacccc agtgagcggc tatgctctct accagcgaca cattaaagca atgcatgagt     3000

cagcactcct ggaggagcag cggcagagac aagaacagat agatttggaa tgtagaagtt     3060

ctacaagtcc atgtggcaca tccaagagtc caaacagaga gtgggaagtc cttcagcctg     3120

ctccacatca agtgataact aatctccctg aaggcgttcg gcttccgaca actcgaccaa     3180

ccaggccacc gccccctctc atcccgtcat ccaaaaccac agtggcttca gaaaaaccat     3240

cttttataat gggaggctcc atctcacagg gaacaccagg cacttatttg acttctcata     3300

atcaggcttc ctacactcaa gaaacaccca agccgtcagt gggatctatc tctcttggac     3360

tgccacggca acaggaatct gccaaatcag ctactttgcc ctacatcaag caggaagaat     3420

tttctccccg aagccaaaac tcacaacctg agggtctgtt ggtcagggcc caacatgaag     3480

gtgtagtcag aggtaccgca ggagccatac aagaaggaag tataactcgg ggaactccaa     3540

ccagcaaaat ttcagtggag agcattccat ccctacgggg ctctatcact cagggcaccc     3600

cggctctgcc ccagactggc ataccaacag aggctttggt gaaggggtcc atttcgagaa     3660

tgcccattga agacagcagt cctgagaaag gcagagagga agctgcatcc aaaggccatg     3720

ttatttatga aggcaaaagt ggacatatct tgtcatatga taatattaag aatgcccgag     3780

aagggactag gagtccaaga acagctcatg aaatcagttt aaagagaagc tatgaatcag     3840

tggaaggaaa tataaagcaa gggatgtcaa tgagggagtc tcctgtatca gcaccgttag     3900

aggggctgat atgccgagca ttacccaggg ggagtcctca ttctgacctc aaagaaagga     3960

ctgtattgtc tggctccata atgcagggga caccaagagc aacaactgaa agctttgaag     4020

atggccttaa atatcccaaa caaattaaaa gggaaagtcc tcccatacga gcatttgaag     4080

gtgccattac caaaggaaaa ccatatgatg gcatcaccac catcaaagaa atggggcgtt     4140

ccattcatga gattccaagg caagatattt taactcagga aagtcggaaa actccagaag     4200

tggtccagag cacacggccg ataattgagg gttccatttc ccagggcaca ccaataaagt     4260

ttgacaacaa ctcaggtcaa tctgccatca aacacaatgt caaatcctta atcacggggc     4320

ctagcaaact atcccgtgga atgcctccgc tggaaattgt gccagagaac ataaaagtgg     4380

tagaacgggg aaaatatgag gatgtgaaag caggcgagac cgtgcgttcc cggcacacgt     4440

cagtggtaag ctctggcccc tccgttctta ggtccacact gcatgaagct cccaaagcac     4500

aactgagccc tgggatttat gatgacacca gtgcacggag gacccctgtg agttatcaaa     4560

acaccatgtc cagaggctca cccatgatga acagaacttc tgatgttaca atttcttcta     4620

acaagtctac caatcatgaa aggaaatcga cactgacccc tacccagagg gaaagtatcc     4680

cagcgaagtc tccagtgcct ggggtggacc ctgtcgtgag ccacagtccg tttgatcccc     4740

atcacagagg cagcactgca ggcgaggttt atcggagcca cctgcccacg cacttggatc     4800

cagccatgcc ttttcacagg gctttggatc ctgcagcggc tgcttacctg tttcagagac     4860

agctttcacc aactccaggt tacccaagtc agtatcagct ttacgcaatg gagaacacaa     4920

gacagacaat cttaaatgat tacattacct cacaacagat gcaagtgaac ttgcgtccag     4980

atgtggccag aggactctcc ccaagagagc agccactggg tctcccatac ccagcaacga     5040

gaggaatcat tgacctgacc aatatgcctc caacaatttt agtgcctcat ccagggggaa     5100

caagcactcc tcccatggac agaatcactt atattcctgg tacacagatt actttccctc     5160

ccaggccgta caactctgct tccatgtctc caggacaccc aacacacctt gcagctgctg     5220

caagtgctga gagggaacgg gaacgggagc gggagaagga gcgggagcgg gaacggattg     5280

ctgcagcttc ctccgacctc tacctgcggc caggctcaga acagcctggc cgacctggca     5340

gtcatggata tgttcgctcc ccttcccctt cagtaagaac tcaggagacc atgttgcaac     5400

agagacccag tgttttccaa ggaaccaatg gaaccagtgt aatcacacct ttggatccaa     5460

ctgctcagct acgaatcatg ccactgcctg ctgggggccc ttcaataagc caaggcctgc     5520

cagcctcccg ttacaacact gctgcggatg ccctggctgc tcttgtggat gctgcagctt     5580

ctgcacccca gatggatgtg tccaaaacaa aagagatatc ttctcacagg tatgaaacac     5640

ctagcgatgc tattgaggtg ataagtcctg ccagctcacc tgcgccaccc caggagaaac     5700

tgcagaccta tcagccagag gttgttaagg caaatcaagc ggaaaatgat cctaccagac     5760

aatatgaagg accattacat cactatcgac cacagcagga atcaccatct ccccaacaac     5820

agctgccccc ttcttcacag gcagagggaa tggggcaagt gcccaggacc catcggctga     5880

tcacacttgc tgatcacatc tgtcaaatta tcacacaaga ttttgctaga aatcaagttt     5940

cctcgcagac tccccagcag cctcctactt ctacattcca gaactcacct tctgctttgg     6000

tatctacacc tgtgaggact aaaacatcaa accgttacag cccagaatcc caggctcagt     6060

ctgtccatca tcaaagacca ggttcaaggg tctctccaga aaatcttgtg gacaaatcca     6120

ggggaagtag gcctggaaaa tccccagaga ggagtcacgt ctcttcggag ccctacgagc     6180

ccatctcccc accccaggtt ccggttgtgc atgagaaaca ggacagcttg ctgctcttgt     6240

ctcagagggg cgcagagcct gcagagcaga ggaatgatgc ccgctcacca gggagtataa     6300

gctacttgcc ttcattcttc accaagcttg aaaatacatc acccatggtt aaatcaaaga     6360

agcaggagat ttttcgtaag ttgaactcct ctggtggagg tgactctgat atggcagctg     6420

ctcagccagg aactgagatc tttaatctgc cagcagttac tacgtcaggc tcagttagct     6480

ctagaggcca ttcttttgct gatcctgcca gtaatcttgg gctggaagac attatcagga     6540

aggctctcat gggaagcttt gatgacaaag ttgaggatca tggagttgtc atgtcccagc     6600

ctatgggagt agtgcctggt actgccaaca cctcagttgt gaccagtggt gagacacgaa     6660

gagaggaagg ggacccatca cctcattcag gaggagtttg caaaccaaag ctgatcagca     6720

agtcaaacag caggaaatct aagtctccta tacctgggca aggctactta ggaacggaac     6780

ggccctcttc agtctcctct gtacattcag aaggggatta ccataggcag acgccagggt     6840

gggcctggga agacaggccc tcttcaacag gctcaactca gtttccttat aaccctctga     6900

ctatgcggat gctcagcagt actccaccaa caccgattgc atgtgctccc tctgcggtga     6960

accaagcagc tcctcaccaa cagaacagga tctgggagcg agagcctgcc ccactgctct     7020

cagcacagta cgagaccctg tcggatagtg atgactgaac tgcacaaagt gaggggaaca     7080

gggtgcagga gagggatctc tagtttttgt ggtttaattt ttagtagcag gtcaaaaacc     7140

tgccctcctg tgacttattc cctgagactt ttcaggagag ccagcccaca gatgatgaag     7200

aaatgatgga agttcatttg gagagtcaaa tgggaaaaaa acaaacaaaa aactgccttt     7260

gatacaggca attcagtgga ctataataat agtggagggt tgagatgtag agtttttaaa     7320

aagtgaacag ttgctgttct tacatctgta aagaaaacca taatgtcttt aaatcactct     7380

tctgtaaata gatgaccttt ttgcagtgta tatccccttg ctgtagtatc tggtgtactt     7440

atgttcaaat cagcgcatca actttggggg tgatttttaa aaatcttttt gtctatctat     7500

ctttttaacc ctagccttct aaacaacctc atacagccca gttacataat gttggctgtc     7560

acgggcattg tacttttatc tgatattgtt tcctctaaat tcagctttcc agtgatgttt     7620

aaaatcttgt gaaaatgttt agatttttaa cacagaccct gtcataaaat ctgtacatta     7680

gggtcaaaag gtaaaagtaa caaattctgc catattgtaa atttccagtg caggctttaa     7740

tttttttttt tcattagtag cactgaaaaa atattactgc atgggtatgt tctagttcag     7800

tttataaagt tttaaaggct tatttgaggc atacctcact gttacgcaca ctggtaattt     7860

aaccatgccc ctaagtattc cttttctcct gcatttgatg cagcccaaca aagcttttgt     7920

tttgaaataa atttgactac cctgtccata                                      7950


<210> 2415
<211> 3419
<212> DNA
<213> Homo sapiens

<400> 2415
tttcagtgga gagcattcca tccctacggg gctctatcac tcagggcaca ccaataaagt       60

ttgacaacaa ctcaggtcaa tctgccatca aacacaatgt caaatcctta atcacggggc      120

ctagcaaact atcccgtgga atgcctccgc tggaaattgt gccagagaac ataaaagtgg      180

tagaacgggg aaaatatgag gatgtgaaag caggcgagac cgtgcgttcc cggcacacgt      240

cagtggtaag ctctggcccc tccgttctta ggtccacact gcatgaagct cccaaagcac      300

aactgagccc tgggatttat gatgacacca gtgcacggag gacccctgtg agttatcaaa      360

acaccatgtc cagaggctca cccatgatga acagaacttc tgatgttaca atttcttcta      420

acaagtctac caatcatgaa aggaaatcga cactgacccc tacccagagg gaaagtatcc      480

cagcgaagtc tccagtgcct ggggtggacc ctgtcgtgag ccacagtccg tttgatcccc      540

atcacagagg cagcactgca ggcgaggttt atcggagcca cctgcccacg cacttggatc      600

cagccatgcc ttttcacagg gctttggatc ctgcagcggc tgcttacctg tttcagagac      660

agctttcacc aactccaggt tacccaagtc agtatcagct ttacgcaatg gagaacacaa      720

gacagacaat cttaaatgat tacattacct cacaacagat gcaagtgaac ttgcgtccag      780

atgtggccag aggactctcc ccaagagagc agccactggg tctcccatac ccagcaacga      840

gaggaatcat tgacctgacc aatatgcctc caacaatttt agtgcctcat ccagggggaa      900

caagcactcc tcccatggac agaatcactt atattcctgg tacacagatt actttccctc      960

ccaggccgta caactctgct tccatgtctc caggacaccc aacacacctt gcagctgctg     1020

caagtgctga gagggaacgg gaacgggagc gggagaagga gcgggagcgg gaacggattg     1080

ctgcagcttc ctccgacctc tacctgcggc caggctcaga acagcctggc cgacctggca     1140

gtcatggata tgttcgctcc ccttcccctt cagtaagaac tcaggagacc atgttgcaac     1200

agagacccag tgttttccaa ggaaccaatg gaaccagtgt aatcacacct ttggatccaa     1260

ctgctcagct acgaatcatg ccactgcctg ctgggggccc ttcaataagc caaggcctgc     1320

cagcctcccg ttacaacact gctgcggatg ccctggctgc tcttgtggat gctgcagctt     1380

ctgcacccca gatggatgtg tccaaaacaa aagagagtaa gcatgaagct gccaggttag     1440

aagaaaattt gagaagcagg tcagcagcag ttagtgaaca gcagcagcta gagcagaaaa     1500

ccctggaggt ggagaagaga tctgttcagt gtttatacac ttcttcagcc tttccaagtg     1560

gcaagcccca gcctcattct tcagtagttt attctgaggc tgggaaagat aaagggcctc     1620

ctccaaaatc cagatatgag gaagagctaa ggaccagagg gaagactacc attactgcag     1680

ctaacttcat agacgtgatc atcacccggc aaattgcctc ggacaaggat gcgagggaac     1740

gtggctctca aagttcagac tcttctagta gcttatcttc tcacaggtat gaaacaccta     1800

gcgatgctat tgaggtgata agtcctgcca gctcacctgc gccaccccag gagaaactgc     1860

agacctatca gccagaggtt gttaaggcaa atcaagcgga aaatgatcct accagacaat     1920

atgaaggacc attacatcac tatcgaccac agcaggaatc accatctccc caacaacagc     1980

tgcccccttc ttcacaggca gagggaatgg ggcaagtgcc caggacccat cggctgatca     2040

cacttgctga tcacatctgt caaattatca cacaagattt tgctagaaat caagtttcct     2100

cgcagactcc ccagcagcct cctacttcta cattccagaa ctcaccttct gctttggtat     2160

ctacacctgt gaggactaaa acatcaaacc gttacagccc agaatcccag gctcagtctg     2220

tccatcatca aagaccaggt tcaagggtct ctccagaaaa tcttgtggac aaatccaggg     2280

gaagtaggcc tggaaaatcc ccagagagga gtcacgtctc ttcggagccc tacgagccca     2340

tctccccacc ccaggttccg gttgtgcatg agaaacagga cagcttgctg ctcttgtctc     2400

agaggggcgc agagcctgca gagcagagga atgatgcccg ctcaccaggg agtataagct     2460

acttgccttc attcttcacc aagcttgaaa atacatcacc catggttaaa tcaaagaagc     2520

aggagatttt tcgtaagttg aactcctctg gtggaggtga ctctgatatg gcagctgctc     2580

agccaggaac tgagatcttt aatctgccag cagttactac gtcaggctca gttagctcta     2640

gaggccattc ttttgctgat cctgccagta atcttgggct ggaagacatt atcaggaagg     2700

ctctcatggg aagctttgat gacaaagttg aggatcatgg agttgtcatg tcccagccta     2760

tgggagtagt gcctggtact gccaacacct cagttgtgac cagtggtgag acacgaagag     2820

aggaagggga cccatcacct cattcaggag gagtttgcaa accaaagctg atcagcaagt     2880

caaacagcag gaaatctaag tctcctatac ctgggcaagg ctacttagga acggaacggc     2940

cctcttcagt ctcctctgta cattcagaag gggattacca taggcagacg ccagggtggg     3000

cctgggaaga caggccctct tcaacaggct caactcagtt tccttataac cctctgacta     3060

tgcggatgct cagcagtact ccaccaacac cgattgcatg tgctccctct gcggtgaacc     3120

aagcagctcc tcaccaacag aacaggatct gggagcgaga gcctgcccca ctgctctcag     3180

cacagtacga gaccctgtcg gatagtgatg actgaactgc acaaagtgag gggaacaggg     3240

tgcaggagag ggatctctag tttttgtggt ttaattttta gtagcaggtc aaaaacctgc     3300

cctcctgtga cttattccct gagacttttc aggagagcca gcccacagat gatgaagaaa     3360

tgatggaagt tcatttggag agtcaaatgg gaaaaaaaca aacaaaaaac tgcctttga      3419


<210> 2416
<211> 6839
<212> DNA
<213> Homo sapiens

<400> 2416
ggggatgcaa gcgggaggat aaagcgatga agtgtgctgc gttaccgcgc atcaggcgct       60

gttgttggag ccggaacacc gtgcgactct gaccgaaccg gccccctcct cgcgcacaca      120

ctcgccgagc cgcgcgcgcc cctccgccgt gacagtggcc gtggcctccg ctctctcggg      180

gcacccggca gccagagcgc agcgagagcg ggcggtcgcc agggtcccct ccccagccag      240

tcccaggcgc ccggtgcact atgcggggca cgtgcgcccc ccagctctaa tctgcgcgct      300

gacaggagca tgatctgtgc ccaggccagg gctgccaaga tatcaatgct atgttcagca      360

gaaacggata cagcaagagc agcatagttc aaaaattgag ggaggcatct tctctctttt      420

cctgggattt aaacgcgatt taggagggca gatgccctac ccgaaaaggc caaccgttaa      480

agaccccggc agtgttgtgg tccaaggcgt ctcaaagcag gtggccagat ctgcgtttct      540

catcagcaga ctcactccgg ctgtggctat tacggaattg atgcgcgtac acgtggtggg      600

tcattatgct gctgcacctg tgtagtgtga agaatctgta ccagaacagg tttttaggcc      660

tggccgccat ggcgtctcct tctagaaact cccagagccg acgccggtgc aaggagccgc      720

tccgatacag ctacaacccc gaccagttcc acaacatgga cctcaggggc ggcccccacg      780

atggcgtcac cattccccgc tccaccagcg acactgacct ggtcacctcg gacagccgct      840

ccacgctcat ggtcagcagc tcctactatt ccatcgggca ctctcaggac ctggtcatcc      900

actgggacat aaaggaggaa gtggacgctg gggactggat tggcatgtac ctcattgatg      960

aggtcttgtc cgaaaacttt ctggactata aaaaccgtgg agtcaatggt tctcatcggg     1020

gccagatcat ctggaagatc gatgccagct cgtactttgt ggaacctgaa actaagatct     1080

gcttcaaata ctaccatgga gtgagtgggg ccctgcgagc aaccaccccc agtgtcacgg     1140

tcaaaaactc ggcagctcct atttttaaaa gcattggtgc tgatgagacc gtccaaggac     1200

aaggaagtcg gaggctgatc agcttctctc tctcagattt ccaagccatg gggttgaaga     1260

aagggatgtt tttcaaccca gacccttatc tgaagatttc cattcagcct gggaaacaca     1320

gcatcttccc cgccctccct caccatggac aggagaggag atccaagatc ataggcaaca     1380

ccgtgaaccc catctggcag gccgagcaat tcagttttgt gtccttgccc actgacgtgc     1440

tggaaattga ggtgaaggac aagtttgcca agagccgccc catcatcaag cgcttcttgg     1500

gaaagctgtc gatgcccgtt caaagactcc tggagagaca cgccataggg gatagggtgg     1560

tcagctacac acttggccgc aggcttccaa cagatcatgt gagtggacag ctgcaattcc     1620

gatttgagat cacttcctcc atccacccag atgatgagga gatttccctg agtaccgagc     1680

ctgagtcagc ccaaattcag gacagcccca tgaacaacct gatggaaagc ggcagtgggg     1740

aacctcggtc tgaggcacca gagtcctctg agagctggaa gccagagcag ctgggtgagg     1800

gcagtgtccc cgatggtcca gggaaccaaa gcatagagct ttccagacca gctgaggaag     1860

cagcagtcat cacggaggca ggagaccagg gcatggtctc tgtgggacct gaaggggctg     1920

gggagctcct ggcccaggtg caaaaggaca tccagcctgc ccccagtgca gaagagctgg     1980

ccgagcagct ggacctgggt gaggaggcat cagcactgct gctggaagac ggtgaagccc     2040

cagccagcac caaggaggag cccttggagg aggaagcaac gacccagagc cgggctggaa     2100

gggaagaaga ggagaaggag caggaggagg agggagatgt gtctaccctg gagcagggag     2160

agggcaggct gcagctgcgg gcctcggtga agagaaaaag caggccctgc tccttgcctg     2220

tgtccgagct ggagacggtg atcgcgtcag cctgcgggga ccccgagacc ccgcggacac     2280

actacatccg catccacacc ctgctgcaca gcatgccctc cgcccagggc ggcagcgcgg     2340

cagaggagga ggacggcgcg gaggaggagt ccaccctcaa ggactcctcg gagaaggatg     2400

ggctcagcga ggtggacacg gtggccgctg acccgtctgc cctggaagag gacagagaag     2460

agcccgaggg ggctactcca ggcacggcgc accctggcca ctccgggggc cacttcccca     2520

gcctggccaa tggcgcggcc caggatggcg acacgcaccc cagcaccggg agcgagagcg     2580

actccagccc caggcaaggc ggggaccaca gttgcgaggg ctgtgacgcg tcctgctgca     2640

gcccctcgtg ctacagctcc tcgtgctaca gcacgtcctg ctacagcagc tcgtgctaca     2700

gcgcctcgtg ctacagcccc tcctgctaca acggcaacag gttcgccagc cacacgcgct     2760

tctcctccgt ggacagcgcc aagatctccg agagcacggt cttctcctcg caagacgacg     2820

aggaggagga gaacagcgcg ttcgagtcgg tacccgactc catgcagagc cctgagctgg     2880

acccggagtc cacgaacggc gctgggccgt ggcaagacga gctggccgcc cctagcgggc     2940

acgtggaaag aagcccggaa ggtctggaat cccccgtggc aggtccaagc aatcggagag     3000

aaggtgaatg tcctatactc cataattccc agccagtaag ccagcttcct tccctgaggc     3060

ctgaacatca tcactaccca acaatcgatg agcctcttcc accaaactgg gaagctcgaa     3120

ttgacagcca cgggcgggtc ttttatgtgg accacgtgaa ccgcacaacc acctggcagc     3180

gtccgacggc agcagccacc ccggatggca tgcggagatc ggggtccatc cagcagatgg     3240

agcaactcaa caggcggtat caaaacattc agcgaaccat tgcaacagag aggtccgaag     3300

aagattctgg cagccaaagc tgcgagcaag ccccagcagg aggaggcgga ggtggaggga     3360

gtgactcaga agccgaatct tcccagtcca gcttagatct aaggagagaa gggtcacttt     3420

ctccagtgaa ctcacaaaaa atcaccttgc tgctgcagtc cccagcggtc aagttcatca     3480

ccaaccccga gttcttcact gtgctacatg ccaattatag tgcctaccga gtcttcacca     3540

gtagcacctg cttaaagcac atgattctga aagtccgacg ggatgctcgc aattttgaac     3600

gctaccagca caaccgggac ttggtgaatt tcatcaacat gttcgcagac actcggctgg     3660

aactgccccg gggctgggag atcaaaacgg accagcaggg aaagtctttt ttcgtggacc     3720

acaacagtcg agctaccact ttcattgacc cccgaatccc tcttcagaac ggtcgtcttc     3780

ccaatcatct aactcaccga cagcacctcc agaggctccg aagttacagc gctggagagg     3840

cctcagaagt ttctagaaac agaggagcct ctttactggc caggccagga cacagcttag     3900

tagctgctat tcgaagccaa catcaacatg agtcattgcc actggcatat aatgacaaga     3960

ttgtggcatt tcttcgccag ccaaacattt ttgaaatgct gcaagagcgt cagccaagct     4020

tagcaagaaa ccacacactc agggagaaaa tccattacat tcggactgag ggtaatcacg     4080

ggcttgagaa gttgtcctgt gatgcggatc tggtcatttt gctgagtctc tttgaagaag     4140

agattatgtc ctacgtcccc ctgcaggctg ccttccaccc tgggtatagc ttctctcccc     4200

gatgttcacc ctgttcttca cctcagaact ccccaggttt acagagagcc agtgcaagag     4260

ccccttcccc ctaccgaaga gactttgagg ccaagctccg caatttctac agaaaactgg     4320

aagccaaagg atttggtcag ggtccgggga aaattaagct cattattcgc cgggatcatt     4380

tgttggaggg aaccttcaat caggtgatgg cctattcgcg gaaagagctc cagcgaaaca     4440

agctctacgt cacctttgtt ggagaggagg gcctggacta cagtggcccc tcgcgggagt     4500

tcttcttcct tctgtctcag gagctcttca acccttacta tggactcttt gagtactcgg     4560

caaatgatac ttacacggtg cagatcagcc ccatgtccgc atttgtagaa aaccatcttg     4620

agtggttcag gtttagcggt cgcatcctgg gtctggctct gatccatcag taccttcttg     4680

acgctttctt cacgaggccc ttctacaagg cactcctgag actgccctgt gatttgagtg     4740

acctggaata tttggatgag gaattccacc agagtttgca gtggatgaag gacaacaaca     4800

tcacagacat cttagacctc actttcactg ttaatgaaga ggtttttgga caggtcacgg     4860

aaagggagtt gaagtctgga ggagccaaca cacaggtgac ggagaaaaac aagaaggagt     4920

acatcgagcg catggtgaag tggcgggtgg agcgcggcgt ggtacagcag accgaggcgc     4980

tggtgcgcgg cttctacgag gttgtagact cgaggctggt gtccgtgttt gatgccaggg     5040

agctggagct ggtgatagct ggcaccgcgg aaatcgacct aaatgactgg cggaataaca     5100

ctgagtaccg gggaggttac cacgatgggc atcttgtgat ccgctggttc tgggctgcgg     5160

tggagcgctt caataatgag cagaggctga gattactgca gtttgtcacg ggaacatcca     5220

gcgtgcccta cgaaggcttc gcagccctcc gtgggagcaa tgggcttcgg cgcttctgca     5280

tagagaaatg ggggaaaatt acttctctcc ccagggcaca cacatgcttc aaccgactgg     5340

atcttccacc gtatccctcg tactccatgt tgtatgaaaa gctgttaaca gcagtagagg     5400

aaaccagcac ctttggactt gagtgaggac atggaacctc gcctgacatt ttcctggcca     5460

gtgacatcac ccttcctggg atgatcccct tttccctttc ccttaatcaa ctctcctttg     5520

attttggtat tccatgattt ttattttcaa accaaatcag gattgacaaa agctgtgcat     5580

gaagaactgc cttcttctaa gatctaacct tcaggcttct ctcctctgtt ttcaatgaac     5640

tgctagcctg tatgcaatat taaaaaacag ctgtctcaag gtctgtgtat atctccacat     5700

acctccatta ctaacaatga aatatgaatg caagttaagc tacacttgac caaatggtaa     5760

taaatgttta cttccatttc tatcattgaa gggaaaatgt gagcattaag cactccaggc     5820

tttcatatgc ccatgtcttc tgagcagagc caccattttt tataatttct aataaccaac     5880

tccagaacta ggagctgatc aactctttgt tttcctctcc atctactttt ccctgtgcat     5940

aatatccatc caaaggacaa cagtggcaaa gctgaaattt ttatacattc aactcatgat     6000

tcacatgtgg catcagtccc atcagccgga actagcctag acatacggtg caaatatgac     6060

acttctaacg attaacaaca gcaagaaaac acctgctgct gatgcaatgc aatgcatccc     6120

aatggttgtg gggattgtgg gctcaactca agagaagttt aggaggggga gcatccctag     6180

tgaatactca caccacaaga aggacaaact tgtgcacatg tccaagaaag aaagcttctt     6240

gattgaggta gcatgaagga tgaggcttca gcccccattg tcttatgtag aatgtggcaa     6300

tgccaactgg agaaagggaa gaaggacata ttaccttggt ttgaatccct gagttctgta     6360

ctgttctgtt ttgtttagtc tagccacagt tcttcacaaa ggaaaaaaaa atgtgtagat     6420

gataccatga cttttgttaa agccatgact tttgtttgct tggcagacaa accctttttt     6480

taaaactttg atattttttt ttcacatttt tttttccttt tcctttctta atcatggagt     6540

tcaagttcct ttgcattcga ttgtccatcg ggaccacact aggaagctgc agagagtgat     6600

ggtgcttgtt agggatcaag ggcaacatag tacttctcct tcacccatag taatcctcct     6660

ggggcagaaa cataacaccc caaaggcacg ttgatttgta tcaaaataaa tatccagttt     6720

cttttagcat tcagtgaaaa catatctcag aaaacttcat gttgtcagaa aaacagctgc     6780

aggctccaaa gacagcctaa cctctcaact acatttgaaa taaacccaac cataatggt      6839


<210> 2417
<211> 1809
<212> DNA
<213> Homo sapiens

<400> 2417
gcttctggcc cctttctctg gaggagctcc gcgcgtggcg agtctgtgtc ctccctgtcc       60

cccagagcag agaaccctct ctgtgtctgg acgggggagg agcagacgct ggacaggttt      120

ttggcaaaat gctggcaatt cccaggaaga tatgtggaga acggaaaggt tgctacaccc      180

aaatagtggc gcaaaggcta tgattatgga ggattggacc tgcaaactcc agaacagagc      240

aaccttgtaa aatgtgtgtg ggcagcacag agaccttggg caagttaaca gtttcctcat      300

ctgtaaatac tgatttatgg aaagcacctg gtgtatgttc tgccctctga ggaccctgcc      360

ctttcccaaa aggggtatct taagaaggaa aatatggctg ctctttgccg gacagcagag      420

tcccaggctg aactccagtg cacccagtta gacttggagc ggaaactcaa gttgaatgaa      480

aatgccatct ccaggctcca ggctaaccaa aagtctgttc tggtgtcggt gtcagaggtc      540

aaagcagtgg ctgaaatgca gtttggggaa ctccttgctg ctgtgaggaa ggcccaggcc      600

aatgtgatgc tcttcttaga ggagaaggag caagctgcgc tgagccaggc caacggtatc      660

aaggcccacc tggagtacag gagtgccgag atggagaaga gtaagcagga gctggagacg      720

atggcggcca tcagcaacac tgtccagttc ttggaggagt actgcaagtt taagaacact      780

gaagacatca ccttccctag tgtttacata gggctgaagg ataaactctc gggcatccgc      840

aaagttatca cggaatccac tgtacactta atccagttgc tggagaacta taagaaaaag      900

ctccaggagt tttccaagga agaggagtat gacatcagaa ctcaagtgtc tgccattgtt      960

cagcgcaaat attggacttc caaacctgag cccagcacca gggaacagtt cctccaatat     1020

gtgcatgaca tcacgttcga cccggacaca gcacacaagt atctccggct gcaggaggag     1080

aaccgcaagg tcaccaacac cacgccctgg gagcatccct acccggacct ccccagcagg     1140

ttcctgcact ggcggcaggt gctgtcccag cagagtctgt acctgcacag gtactatttt     1200

gaggtggaga tcttcggggc aggcacctat gttggcctga cctgcaaagg catcgaccag     1260

aaaggggagg agcgcagcag ttgcatttcc ggaaacaact tctcctggag cctccaatgg     1320

aacgggaagg agttcacggc ctggtacagt gacatggaga ccccactcaa agctggccct     1380

ttctggaggc tcggggtcta tattgacttc ccaggaggga tcctttcctt ctatggcgta     1440

gagtatgatt ccatgactct ggttcacaag tttgcctgca agttttcaga accagtctat     1500

gctgccttct ggctttccaa gaaggaaaac gccatccgga ttgtagatct gggagaggaa     1560

cccgagaagc cagcaccgtc cttggtgggg actgctccct agactccagg agccatatcc     1620

cagacctttg ccagctacag tgatgggatt tgcattttag ggtgatttgg gggcaaaaat     1680

aactgctgat ggtagctggc ttttgaaatc ctatggggtc tctgaatgaa aacattctcc     1740

agctgctctc ttttgctcca tatggtgctg ttctctatgt gtttgcagta attctttttt     1800

ttttttttt                                                             1809


<210> 2418
<211> 2392
<212> DNA
<213> Homo sapiens

<400> 2418
gagcagcggc tctggcggtc gtggcggtcg gagatccgag agctctgctt ctctgaaaag       60

cgtgtggctt tctggacttg tttcaggcca cccacgagcc agcgggaaag gattgccagc      120

cagagaaaga cgaactccga agtcccaatg cacagatcag cccccagtca aaccaccaag      180

aggagccgat cgccattttc cactactcgt cgtagttggg acgacagcga gagttcggga      240

accaacctga atattgataa tgaggactat tccaggtatc cgccaagaga gtacagagct      300

tcgggtagca gaagaggaat ggcctatgga catattgact cttatggggc agatgatagt      360

gaggaggagg gggctgggcc tgttgagcga ccgccagtga gagggaaaac tggcaagttt      420

aaagatgata agctgttaga cccagtccct gcagcaagat gctcagctag cagagctgac      480

ttcctgccac aaagtagtgt ggcctcacag tcgtcttctg aaggcaagct ggctacaaaa      540

ggtgacagct cggagaggga gagaagggag caaaatttac ctgcacgtcc cagcagggct      600

cctgtgagta tttgtggtgg tggggaaaac acctcaaaga gtgcagagga acctgtggtc      660

aggcccaaaa tcagaaacct ggcaagtcca aactgcgtga aaccaaaaat tttttttgat      720

actgatgatg atgacgatat gccacacagt acttccaggt ggagggatac cgccaatgac      780

aatgagggcc actcggatgg cctggcaaga agagggagag gcgagagttc aagtggctat      840

cccgagccaa agtaccctga agacaaacgg gaagcgagga gtgaccaagt gaaaccagaa      900

aaggtgccga gacgacgacg caccatggcc gaccctgact tctggacgca cagtgatgat      960

tactacaaat actgcgacga agactctgac agtgacaaag agtggattgc tgctctgcgt     1020

cggaaatatc gaagccgaga gcaaaccctg tcctccagtg gcgaaagctg ggagactctg     1080

ccggggaaag aagagcggga acctccacag gctaaggtga gtgccagcac tggcaccagc     1140

cctggccccg gtgctagtgc cagtgccggg gctggcgccg gggccagtgc tggcagcaat     1200

ggcagcaatt accttgaaga agttcgagaa ccatctcttc aggaagagca ggcatccctg     1260

gaagaaggag aaattccttg gctccagtac catgagaatg acagtagcag tgagggggat     1320

aatgattctg gtcacgagtt gatgcaacct ggggtattca tgctggatgg aaacaacaac     1380

cttgaagatg actccagtgt gagcgaagac ctagaagtgg attggagcct ctttgatgga     1440

tttgcagatg ggttaggagt ggctgaagcc atttcctatg tggaccctca gttcctcacc     1500

tacatggcac ttgaagaacg cctggcccag gcaatggaaa ctgcccttgc gcacttggag     1560

tctctcgcag tggatgtaga ggtggccaat ccaccagcaa gcaaggagag cattgacgct     1620

cttcccgaga tcctggtcac tgaagatcat ggcgcagttg gtcaggagat gtgctgcccc     1680

atctgctgta gcgaatatgt gaagggggag gtggcaactg agctgccgtg ccaccactat     1740

ttccacaagc cgtgtgtgtc catctggctt cagaagtcag gcacctgccc cgtgtgccgc     1800

tgcatgttcc ctcccccact ctaaagacca aggccgttta ctcctggtct gattattttc     1860

cccatctgaa atccacaata ctgcaggagc cctcttgaaa ttaacaatgg aaataaaacc     1920

aatcagtcag ttagcctaaa cctattgatt cctcgtgatt atttccaatg tgaaaacagt     1980

tgtgtatgat tgcattaaaa atcatatcat cttttagagg ttagaaaagg gaaaactaaa     2040

ctttctaaat gctacttgag attgcagtaa gaagatacgt tttctaacct gaaagttaaa     2100

tcgcatttgt tttcttcagt agaatgggaa tgtgttgctg ttacttgtaa tgtcaagttt     2160

atctgttaaa tatgtccaaa aggcaaaatc atttttgttg catgttatgg gtcgatgttc     2220

ctgtaattgc agtgccgtaa aagcttatta aagttgttct tttggtttta catggtataa     2280

tggaattttt tggttttgtc tgaagcagtg gtactgaatg actttataat tgatcccttg     2340

catttgcatc aaaagcttta gtttcactgg aaatgctgac ttcaacaatt gc             2392


<210> 2419
<211> 4672
<212> DNA
<213> Homo sapiens

<400> 2419
gtgccaccat gcccagctga gttacgcagc gtgacaaatg gtcagtctaa ccaaccaagt       60

aatgaaggtg atgccatcaa agtttttgtg cgaattcgtc ctcctgcaga aagatctggg      120

tcagctgatg gagagcagaa cttatgctta tctgtgctgt cctccacgag tctccggctg      180

cactccaacc ctgagcccaa gaccttcacg tttgatcatg ttgcagatgt ggataccact      240

caggaatctg tattcgcaac tgtggctaaa agcattgtgg agtcttgcat gagcggttat      300

aatggtacca tctttgcata tggacagact ggctcaggga agacatttac tatgatggga      360

ccatctgaat ctgataattt ttctcataac ctgagaggag taatcccacg aagttttgaa      420

tatttgtttt ccttaattga tcgtgaaaaa gaaaaggctg gagctggaaa gagtttcctt      480

tgtaagtgtt cctttattga aatctacaac gagcagatat atgatctact ggactctgca      540

tcggctggac tgtacttaag ggagcatatc aagaagggag tctttgttgt tggtgcggtg      600

gagcaggtgg taacctcagc tgctgaagcc tatcaggtgt tgtctggagg atggaggaat      660

agacgtgtgg catcaacatc aatgaacaga gaatcgtcta ggtctcatgc cgtctttaca      720

attacaatag agtcaatgga gaaaagtaat gagattgtga atatacggac ctccctactc      780

aacctggtgg atttagcagg atctgaaagg caaaaagata cccatgcaga agggatgaga      840

ttgaaggaag caggtaacat aaatcgatca ttgagctgcc tgggccaagt gattacagca      900

cttgtcgacg tgggtaatgg aaaacagaga catgtttgct acagagactc caaacttacc      960

ttcttactac gggattccct tggaggtaat gccaaaacag ccataattgc aaatgttcat     1020

cctggatcca ggtgttttgg ggaaacccta tcaacactta actttgctca aagagccaag     1080

ctgattaaaa acaaggcagt agtaaatgaa gacacccaag gaaatgtgag ccagctccaa     1140

gctgaagtga agaggctcaa agaacaactg gcggagcttg cttcaggaca gacaccacca     1200

gaaagcttcc tgaccagaga caaaaagaag actaactata tggagtattt ccaggaagca     1260

atgttattct ttaagaaatc tgaacaggaa aagaagtctc tgatagaaaa agttacccaa     1320

ttagaagacc tcaccctcaa aaaggaaaaa tttattcaat ctaataaaat gattgtgaaa     1380

ttccgagagg atcaaataat acgcttggaa aagctccaca aggaatcccg gggaggtttt     1440

ctgcctgagg agcaggatcg tttgctctca gaattaagga atgagattca aactctgcga     1500

gaacaaatag agcaccaccc cagagttgca aagtatgcta tggaaaatca ttccctcagg     1560

gaggagaata gaagactgag attattagag cctgtgaaaa gagctcaaga aatggatgcc     1620

cagaccattg caaaactaga aaaagctttc tctgaaataa gtggcatgga gaaaagtgac     1680

aaaaatcagc aaggattttc acctaaagct cagaaagagc catgtttgtt tgcaaacact     1740

gagaagttaa aagcacaact cctgcaaatt cagacagagc tgaataattc aaagcaagaa     1800

tatgaagaat tcaaagaact tactaggaaa aggcagctag aattggaatc agagcttcag     1860

tctttgcaaa aagcgaacct taatcttgaa aaccttttgg aagcaacaaa agcctgcaag     1920

cggcaagaag tttctcagct gaataaaatt catgctgaaa cacttaagat tataactaca     1980

ccaaccaagg cctaccaact tcattcccga ccagtaccaa aattaagccc tgaaatggga     2040

agctttggct ctctatacac tcagaattct agcatattag ataatgatat attaaatgag     2100

ccagttcctc ctgagatgaa tgaacaagct tttgaggcca tttctgaaga gcttagaaca     2160

gtgcaggaac aaatgagtgc tcttcaagcc aaactggatg aagaagagca taaaaaccta     2220

aagcttcagc agcatgttga caaactggaa catcattcta cccaaatgca ggagcttttc     2280

tcatcagaaa gaattgattg gaccaaacag caggaagagc ttctctcaca gttgaatgtc     2340

cttgaaaagc agcttcaaga gactcaaact aaaaatgact ttttgaaaag tgaggtacat     2400

gacctgcgag tagtccttca ttctgctgac aaggagcttt cttcagtgaa attggaatat     2460

agttcattca aaacgaatca ggagaaagaa ttcaacaaac tttccgaaag acacatgcat     2520

gtacagcttc aattagataa tctcaggtta gaaaacgaaa agctgcttga gagcaaagcc     2580

tgcctacagg attcctatga caacttacaa gaaataatga aatttgagat tgaccaactt     2640

tcaagaaacc tccaaaactt caaaaaagaa aatgaaactc tgaaatctga tctgaataat     2700

ttgatggagc ttcttgaggc agaaaaagaa cgcaataaca aattatcatt acagtttgaa     2760

gaagataaag aaaacagttc taaagaaatc ttaaaagttc ttgaggctgt acgtcaggag     2820

aaacagaaag agacggccaa gtgtgagcag cagatggcaa aagtacagaa actagaagag     2880

agcttgcttg ctactgaaaa agtgatcagt tccctggaaa agtctagaga ttctgataag     2940

aaagttgtag ctgacctcat gaaccagatc caggagctaa gaacatcggt ctgtgagaaa     3000

acagaaacta tagacaccct gaaacaagaa ctgaaggaca taaattgcaa atacaactct     3060

gctttggttg acagagaaga gagcagagtg ttgatcaaga agcaggaagt ggatattctg     3120

gatctgaaag aaacccttag gctgagaata ctttctgagg acatagagag ggatatgctc     3180

tgtgaggacc tggctcatgc cactgagcag ctgaacatgc tcacagaggc ctcaaaaaaa     3240

cactcggggc tgctgcagtc tgcccagaga actgaccaag aaggaagccc tgattcagga     3300

acttcagcac aagctaaacc aaaagaaaga ggaagtagaa cagaagaaga atataacttc     3360

aaaatgaggc aactagaaca tgtgatggat tctgctgctg aggatcccca gagtcctaag     3420

acaccacctc actttcaaac acatttggca aaactcctgg aaacacaaga acaagagata     3480

gaagatggaa gagcctctaa gacttctttg gaacaccttg taacaaagct aaatgaagac     3540

agagaagtca aaaatgctga aatcctcaga atgaaggagc agttgcgtga aatggaaaac     3600

ctacgcctgg aaagtcagca gttaatagag aaaaactggc tcctgcaagg tcagctggat     3660

gatattaaaa gacaaaagga aaacagtgat cagaatcatc cagataatca acagctgaag     3720

aatgaacaag aagaaagtat caaagaaaga cttgcaaaaa gtaaaatagt tgaagaaatg     3780

ctgaaaatga aagcagacct agaagaagtc caaagtgccc tttacaacaa agagatggaa     3840

tgccttagaa tgactgatga agtcgaacga acccaaactt tggagtctaa agcattccag     3900

gaaaaagaac aactgagatc aaagctggaa gaaatgtatg aagaaagaga gagaacatcc     3960

caggagatgg aaatgttaag gaagcaggtg gagtgtcttg ctgaggaaaa tggaaagttg     4020

gtaggtcacc aaaatttgca tcagaagatt cagtacgtag tgcgactaaa gaaggaaaat     4080

gtcaggcttg ctgaggagac agaaaagttg cgtgccgaaa atgtattttt aaaagaaaag     4140

aaaagaagtg aatcttgagg attccggtca gctacctagg catcaccttg tttgaagatg     4200

tttcttctct tttacaagta agacctactc ctggccactt aggagagctg aatttatgga     4260

ccttaattat taaatgttta taaggtggtg gtaaccacct caagtttctg atgaacattc     4320

tgcatccata tacaccctgt gacagtcagc agtctgctat taagtggcct acttcaaggc     4380

tttgaatcaa cttaagggaa aaccttttgt ctttgtaaaa ataaaagcct gtagctaagg     4440

tttacagtgg acattagcca gatcattttc ttcttagatt atgccataat ctcctttgat     4500

tcttatggaa gttctaacaa tatatggtgg ttccaacacc tgcagtgagt ttaatgactg     4560

acttagtagc aggtacaaga agcaaacttg ttaatataga ttatttttgt attcttactt     4620

taggtatttt cttgagcatt ttccatgact gtaaataaag ccatttttta ag             4672


<210> 2420
<211> 4661
<212> DNA
<213> Homo sapiens

<400> 2420
ggctcggcgc tgaaattcaa atttgaacgg ctgcagaggc cgagtccgtc actggaagcc       60

gagaggagag gacagctggt tgtgggagag ttcccccgcc tcagactcct ggttttttcc      120

aggagacaca ctgagctgag actcactttt ctcttcctga atttgaacca ccgtttccat      180

cgtctcgtag tccgacgcct ggggcgatgg atccgtttac ggagaaactg ctggagcgaa      240

cccgtgccag gcgagagaat cttcagagaa aaatggctga gaggcccaca gcagctccaa      300

ggtctatgac tcatgctaag cgagctagac agccactttc agaagcaagt aaccagcagc      360

ccctctctgg tggtgaagag aaatcttgta caaaaccatc gccatcaaaa aaacgctgtt      420

ctgacaacac tgaagtagaa gtttctaact tggaaaataa acaaccagtt gagtcgacat      480

ctgcaaaatc ttgttctcca agtcctgtgt ctcctcaggt gcagccacaa gcagcagata      540

ccatcagtga ttctgttgct gtcccggcat cactgctggg catgaggaga gggctgaact      600

caagattgga agcaactgca gcctcctcag ttaaaacacg tatgcaaaaa cttgcagagc      660

aacggcgccg ttgggataat gatgatatga cagatgacat tcctgaaagc tcactcttct      720

caccaatgcc atcagaggaa aaggctgctt cccctcccag acctctgctt tcaaatgcct      780

cggcaactcc agttggcaga aggggccgtc tggccaatct tgctgcaact atttgctcct      840

gggaagatga tgtaaatcac tcatttgcaa aacaaaacag tgtacaagaa cagcctggta      900

ccgcttgttt atccaaattt tcctctgcaa gtggagcatc tgctaggatc aatagcagca      960

gtgttaagca ggaagctaca ttctgttccc aaagggatgg cgatgcctct ttgaataaag     1020

ccctatcctc aagtgctgat gatgcgtctt tggttaatgc ctcaatttcc agctctgtga     1080

aagctacttc tccagtgaaa tctactacat ctatcactga tgctaaaagt tgtgagggac     1140

aaaatcctga gctacttcca aaaactccta ttagtcctct gaaaacgggg gtatcgaaac     1200

caattgtgaa gtcaacttta tcccagacag ttccatccaa gggagaatta agtagagaaa     1260

tttgtctgca atctcaatct aaagacaaat ctacgacacc aggaggaaca ggaattaagc     1320

ctttcctgga acgctttgga gagcgttgtc aagaacatag caaagaaagt ccagctcgta     1380

gcacacccca cagaaccccc attattactc caaatacaaa ggccatccaa gaaagattat     1440

tcaagcaaga cacatcttca tctactaccc atttagcaca acagctcaag caggaacgtc     1500

aaaaagaact agcatgtctt cgtggccgat ttgacaaggg caatatatgg agtgcagaaa     1560

aaggcggaaa ctcaaaaagc aaacaactag aaaccaaaca ggaaactcac tgtcagagca     1620

ctcccctcaa aaaacaccaa ggtgtttcaa aaactcagtc acttccagta acagaaaagg     1680

tgaccgaaaa ccagatacca gccaaaaatt ctagtacaga acctaaagaa gtgatacgtg     1740

aaattgagat gagtgtggat gatgatgata tcaatagttc gaaagtaatt aatgacctct     1800

tcagtgatgt cctagaggaa ggtgaactag atatggagaa gagccaagag gagatggatc     1860

aagcattagc agaaagcagc gaagaacagg aagatgcact gaatatctcc tcaatgtctt     1920

tacttgcacc attggcacaa acagttggtg tggtaagtcc agagagttta gtgtccacac     1980

ctagactgga attgaaagac accagcagaa gtgatgaaag tccaaaacca ggaaaattcc     2040

aaagaactcg tgtccctcga gctgaatctg gtgatagcct tggttctgaa gatcgtgatc     2100

ttctttacag cattgatgca tatagatctc aaagattcaa agaaacagaa cgtccatcaa     2160

taaagcaggt gattgttcgg aaggaagatg ttacttcaaa actggatgaa aaaaataatg     2220

cctttccttg tcaagttaat atcaaacaga aaatgcagga actcaataac gaaataaata     2280

tgcaacagac agtgatctat caagctagcc aggctcttaa ctgctgtgtt gatgaagaac     2340

atggaaaagg gtccctagaa gaagctgaag cagaaagact tcttctaatt gcaactggga     2400

agagaacact tttgattgat gaattgaata aattgaagaa cgaaggacct cagaggaaga     2460

ataaggctag tccccaaagt gaatttatgc catccaaagg atcagttact ttgtcagaaa     2520

tccgcttgcc tctaaaagca gattttgtct gcagtacggt tcagaaacca gatgcagcaa     2580

attactatta cttaattata ctaaaagcag gagctgaaaa tatggtagcc acaccattag     2640

caagtacttc aaactctctt aacggtgatg ctctgacatt cactactaca tttactctgc     2700

aagatgtatc caatgacttt gaaataaata ttgaagttta cagcttggtg caaaagaaag     2760

atccctcagg ccttgataag aagaaaaaaa catccaagtc caaggctatt actccaaagc     2820

gactcctcac atctataacc acaaaaagca acattcattc ttcagtcatg gccagtccag     2880

gaggtcttag tgctgtgcga accagcaact tcgcccttgt tggatcttac acattatcat     2940

tgtcttcagt aggaaatact aagtttgttc tggacaaggt ccccttttta tcttctttgg     3000

aaggtcatat ttatttaaaa ataaaatgtc aagtgaattc cagtgttgaa gaaagaggtt     3060

ttctaaccat atttgaagat gttagtggtt ttggtgcctg gcatcgaaga tggtgtgttc     3120

tttctggaaa ctgtatatct tattggactt atccagatga tgagaaacgc aagaatccca     3180

taggaaggat aaatctggct aattgtacca gtcgtcagat agaaccagcc aacagagaat     3240

tttgtgcaag acgcaacact tttgaattaa ttactgtccg accacaaaga gaagatgacc     3300

gagagactct tgtcagccaa tgcagggaca cactctgtgt taccaagaac tggctgtctg     3360

cagatactaa agaagagcgg gatctctgga tgcaaaaact caatcaagtt cttgttgata     3420

ttcgcctctg gcaacctgat gcttgctaca aacctattgg aaagccttaa accgggaaat     3480

ttccatgcta tctagaggtt tttgatgtca tcttaagaaa cacacttaag agcatcagat     3540

ttactgattg cattttatgc tttaagtacg aaagggtttg tgccaatatt cactacgtat     3600

tatgcagtat ttatatcttt tgtatgtaaa actttaactg atttctgtca ttcatcaatg     3660

agtagaagta aatacattat agttgatttt gctaaatctt aatttaaaag cctcattttc     3720

ctagaaatct aattattcag ttattcatga caatattttt ttaaaagtaa gaaattctga     3780

gttgtcttct tggagctgta ggtcttgaag cagcaacgtc tttcaggggt tggagacaga     3840

aacccattct ccaatctcag tagttttttc gaaaggctgt gatcatttat tgatcgtgat     3900

atgacttgtt actagggtac tgaaaaaaat gtctaaggcc tttacagaaa catttttagt     3960

aatgaggatg agaacttttt caaatagcaa atatatattg gcttaaagca tgaggctgtc     4020

ttcagaaaag tgatgtggac ataggaggca atgtgtgaga cttgggggtt caatatttta     4080

tatagaagag ttaataagca catggtttac atttactcag ctactatata tgcagtgtgg     4140

tgcacatttt cacagaattc tggcttcatt aagatcatta tttttgctgc gtagcttaca     4200

gacttagcat attagttttt tctactccta caagtgtaaa ttgaaaaatc tttatattaa     4260

aaaagtaaac tgttatgaag ctgctatgta ctaataatac tttgcttgcc aaagtgtttg     4320

ggttttgttg ttgtttgttt gtttgtttgt ttttggttca tgaacaacag tgtctagaaa     4380

cccattttga aagtggaaaa ttattaagtc acctatcacc tttaaacgcc tttttttaaa     4440

attataaaat attgtaaagc agggtctcaa cttttaaata cactttgaac ttcttctctg     4500

aattattaaa gttctttatg acctcattta taaacactaa attctgtcac ctcctgtcat     4560

tttatttttt attcattcaa atgtattttt tcttgtgcat attataaaaa tatattttat     4620

gagctcttac tcaaataaat acctgtaaat gtctaaagga a                         4661


<210> 2421
<211> 916
<212> DNA
<213> Homo sapiens

<400> 2421
ttctcgccta acgccgccaa catggtgagt cttactgttg cgggctccgg ggccgtcgac       60

catgccgctc gacctccacc tccgctggga agctgaggcg ccaaacggct cccagagggt      120

cccgggaagc gcatggtgtt caggcgcttc gtggaggttg gccgggtggc ctatgtctcc      180

tttggacctc atgccggaaa attggtcgcg attgtagatg ttattgatca gaacagggct      240

ttggtcgatg gaccttgcac tcaagtgagg agacaggcca tgcctttcaa gtgcatgcag      300

ctcactgatt tcatcctcaa gtttccgcac agtgcccacc agaagtatgt ccgacaagcc      360

tggcagaagg cagacatcaa tacaaaatgg gcagccacac gatgggccaa gaagattgaa      420

gccagagaaa ggaaagccaa gatgacagat tttgatcgtt ttaaagttat gaaggcaaag      480

aaaatgagga acagaataat caagaatgaa gttaagaagc ttcaaaaggc agctctcctg      540

aaagcttctc ccaaaaaagc acctggtact aagggtactg ctgctgctgc tgctgctgct      600

gctgctgcta aagttccagc aaaaaagatc accgccgcga gtaaaaaggc tccagcccag      660

aaggttcctg cccagaaagc cacaggccag aaagcagcgc ctgctccaaa agctcagaag      720

ggtcaaaaag ctccagccca gaaagcacct gctccaaagg catctggcaa gaaagcataa      780

gtggcaatca taaaaagtaa taaaggttct ttttgacctg ttgacaaatg tatttaagcc      840

tttggattta aagcctgttg aggctggagt taggaggcag attgatagta ggattataat      900

aaacattaaa taatca                                                      916


<210> 2422
<211> 5252
<212> DNA
<213> Homo sapiens

<400> 2422
taatatggcg gggaggagga ggagaaggcg gcggcggacc gagctgcgct ctgtcagtac       60

catttgagcc attcgcttcc tgacaaggcc cgtggcgagg ggagaggagc tgaaggggcc      120

gtgggggatc agtgtgactg tgggaagatg gaggagtatg agaagttctg tgaaaaaagt      180

cttgccagaa tacaagaagc atcactatcc acagagagct ttctccctgc tcagtctgaa      240

agtatctcac ttattcgctt tcatggagtg gctatccttt ctccactgct taacattgag      300

aaaagaaagg aaatgcaaca agaaaagcag aaagcacttg atgtagaagc aagaaagcag      360

gttaacagga agaaagcttt actgactcgt gtccaggaga ttcttgacaa tgttcaggtt      420

agaaaagcac ctaatgccag tgattttgat cagtgggaga tggaaacagt ttactctaat      480

tcagaagtca gaaacttgaa tgttcctgct acatttccaa atagctttcc aagccatacg      540

gaacactcta ctgcagcaaa gcttgataag atagctggga ttttgccatt ggataatgag      600

gaccaatgta aaactgatgg aatagactta gctagagatt cagaaggatt taattctccg      660

aagcaatgtg atagttccaa tattagtcat gtagaaaatg aagcttttcc aaagacctct      720

tcagcaaccc cacaagaaac tcttatttct gatggtccct tctcagtaaa tgaacaacag      780

gatctaccac ttttggcaga agtcatccca gatccctatg taatgagtct tcagaatctg      840

atgaaaaagt caaaggaata tatagaaaga gaacaatcta gacgcagtct gagaggtagt      900

atcaacagaa ttgttaatga gagtcattta gacaaagaac atgatgctgt tgaagtggct      960

gactgtgtaa aagagaaagg ccagttgaca ggcaaacact gtgtctcagt tattcctgac     1020

aaaccaagcc ttaataaatc aaatgttctt ctccaaggtg cttccactca agcaagcagc     1080

atgagtatgc cagttttagc tagcttttcg aaagtggaca tacctatacg aactggccat     1140

cccactgttc tagagtctaa ttctgatttt aaagttattc ccacttttgt taccgaaaat     1200

aatgttatca aaagtcttac aggttcatat gccaaattac ctagtccaga gccaagtatg     1260

agtcctaaaa tgcaccgaag acgttccagg acatcatcag cgtgtcatat acttataaat     1320

aacccaataa atgcctgtga attaagccct aaaggaaaag aacaggcaat ggacttaatt     1380

attcaagata ctgatgaaaa cacaaatgtg cccgaaatta tgccaaagtt accaactgat     1440

ttagcgggag tttgttcaag caaggtttat gtgggcaaaa atacatctga agtcaaagaa     1500

gatgtggttt taggtaaatc aaatcaggta tgtcaatctt caggaaatca tttagaaaat     1560

aaagttactc atggacttgt tactgtggaa ggtcagttaa catccgatga gagaggcgca     1620

cacataatga acagtacctg tgctgcgatg ccaaagctgc atgaaccata tgccagcagt     1680

cagtgtatag caagtccaaa ctttggaact gtgagtggac tcaagccagc cagtatgtta     1740

gagaaaaact gcagtttgca aacagaactg aataagtctt atgatgtaaa aaacccttct     1800

cctttattga tgcaaaacca gaatacgaga cagcagatgg acacacctat ggtgtcctgt     1860

ggaaatgaac aatttttgga taacagtttt gagaaagtta aacggagact tgatttagat     1920

attgatggtt tgcaaaaaga aaactgccct tatgtcataa caagtggaat aactgaacaa     1980

gaaaggcaac atttgccaga aaaaagatac cctaagggat ctggcttcgt taacaagaat     2040

aaaatgttag gaactagttc caaagaaagc gaggagttac taaaaagcaa gatgttagct     2100

tttgaagaaa tgcggaagag actagaagaa cagcacgccc agcaattatc actactcata     2160

gctgagcagg aaagggaaca agaaagactg caaaaggaaa tagaagagca ggagaaaatg     2220

ttaaaagaga agaaggcaat gacagcggaa gcctctgagt tggacattaa caatgcagtg     2280

gaattagaat ggagaaaaat aagtgactct agtttgctgg aaacaatgct gtctcaagcg     2340

gactcactcc atacttcaaa ttcaaatagt tctggtttca caaattctgc catgcaatat     2400

agctttgttt ctgcaaacga agcaccattc tacctctggg gatcatcaac tagtggcttg     2460

accaaactct cagtaacaag gccttttgga agagccaaaa ctagatggtc tcaagttttt     2520

agtctggaaa tacaagcaaa atttaacaaa ataactgcag tggcaaaagg atttcttact     2580

cgtagactta tgcagacaga taagctgaag caacttcgac aaactgtaaa agatactatg     2640

gaattcataa gaagttttca gtcagaagca ccattaaaga gaggcattgt ttcagctcaa     2700

gatgcttcac ttcaggaaag agtgttagct cagttgcgag ctgccttgta cggtattcat     2760

gacatattct ttgtaatgga tgcagctgaa agaatgtcta ttctacatca tgatcgagaa     2820

gttcgcaaag agaaaatgct caggcaaatg gataaaatga aaagtccacg agtggctctt     2880

tcagctgcaa cacagaagtc tcttgatagg aagaaataca tgaaagctgc tgaaatggga     2940

atgccaaata agaaatttct ggttaaacaa aatccttctg aaacaagagt ccttcagcca     3000

aaccaaggac agaatgcacc tgttcatagg ctacttagta gacaagggag tatatgcagg     3060

aaaaatccaa agaaagcggc caaatgttgc gacaatttaa gaagacaaca ttcattagga     3120

taaaatgggg ggaaggatta ttattcatgt tattttccct gcccaagact ttatttaacc     3180

ctggactccg tttacacaga caaagtgaca tcagaaggct gagcacttat ctggatcatt     3240

tggtcagttt ggtaattcct gctccacacc cctattttcc tcttaataat acgtttgggt     3300

gaagacaaat tagtgtttag taattgcatc atctctgtgc ttacctatac aaacataagt     3360

ttattttata tgcccagatg tctacagaga ccctttttgt aaatgtcaag gacatttgga     3420

tttactttta cagaatattg aaaagataag acaaattata aataagttct aaaacataaa     3480

tttaattcat ctctgcatag tgatttttga atttgattca aagggaaatt attgcagaag     3540

aatgcctttc cctcatttta taactttaaa aacttggatt aaccactcaa tgtccacttt     3600

ctttgactta cagtataacc atgtagccaa ttgtggccca ctaaaatcta cagaagttaa     3660

tgtgggtcac cattttggtc agaagcatac attcctgtca gacaactagt tgtctgacag     3720

aaatgttagg cttcatgtat gttaccccag tactgttaga aacatttgta ctaggttata     3780

agatctttct gtgacaggta acaaatttgg ggaagacagc acaatcttct tgaatgtagc     3840

tcttgggaat gcattattac atccatttct gtaacataat aatatgttgc atgcagttat     3900

attttctatt tagtctgtat attttgttct tcatagtctg ttttttctag catgcttgat     3960

ttaggagaga ataaagggct atataataat aaatccagat ttccggataa gaatattgcc     4020

tggttaaaat tctgcattgc ttaaagacac ccatgtttaa gatttttcat cactaacata     4080

tccattaaaa gtatcaactg gccaggcagg gtggctcacg cctgtactcc cagcattttg     4140

tgaggccaag gtgggtggat cacctgaggt caggagtttg agaccagcct gaccaaacat     4200

ggcgaaaccc catctgtact gaaaatacaa aaattaggca tggtggtgca tgcctgtagt     4260

tccagctact tgggaggctg agacaggcga attgcttgaa cctgggaggc agaggttgca     4320

gtgagctgag actgtgccat tgcactccag tcgggttaac agagcaagac actgtctcaa     4380

aaaaaaaaaa aaaaaaaagt atcaaccaac aaatgttacc aagataacgt gacttcatga     4440

gggagaatgt cactattaat ttatcatacc atttccaaaa agggctttgt gcttttcaca     4500

taaaattgag acagtgtata tttaatctaa tttaaatttt aaagagatac tggtattttg     4560

aaaatgcaac ctatatatat tcttaatatc cttttaagaa tatggagatg aagattgttt     4620

tctccaattt tctgtgccat tttaaattta actttgacat ccagctatag acagaaataa     4680

taagccaccc tgggtgtaaa cttgattttc tttattgaga tgtatcatgt attgaatgag     4740

tgaaccagaa aattagaaga tggtcaaaaa aagtccaagt taccaatttt ttaaaattta     4800

taggcaaagt atcaaattgt cttcttaata tgataaactg tgctttatca ttctgaaaac     4860

tcaggataca gcttattcat agcattgtgg gtctctccag taagaaagat gctaaaagtt     4920

ttgtgcactt tttgtgtgtg taatgcaaat tagttaaaac aaatagtttt ggagaaagtt     4980

aaaactagct ttagagtaag gatgagaaac ttgagtgttt ttaatttaaa gataaaagcc     5040

tgtgttttac acattctttt ttggtgttca tagcttcttc tcatacaggt gccagacact     5100

gtttgtgctt ttgatggatt tttatttata tacttttttt gcttattttt actttgagtg     5160

gaatgttcat taatgtaaat tgtatttatt tttatacttt tattttcact agttttgctt     5220

ctaggcaaaa agcaaaataa acttttcatc tt                                   5252


<210> 2423
<211> 5474
<212> DNA
<213> Homo sapiens

<400> 2423
ggccctgaga ggtggagtcg gggtggcagc ggcggcggtt gccaggagcc cgcgttgcag       60

cctgagatcc gtaatatggc ggggaggagg aggagaaggc ggcggcggac cgagctgcgc      120

tctgtcagta ccatttgagc cattcgcttc ctgacaaggc ccgtggcgag gggagaggag      180

ctgaaggggc cgtgggggat cagtgcctgc tgtgtgctga tactgttctg tgtaatgggg      240

attcagtgaa caagactgaa aaggtacctg tacttatggc gcttacattt tggtggagga      300

agacagacaa aaatcaagga aataaacacg ataatttcag atagtgtgtg actgtgggaa      360

gatggaggag tatgagaagt tctgtgaaaa aagtcttgcc agaatacaag aagcatcact      420

atccacagag agctttctcc ctgctcagtc tgaaagtatc tcacttattc gctttcatgg      480

agtggctatc ctttctccac tgcttaacat tgagaaaaga aaggaaatgc aacaagaaaa      540

gcagaaagca cttgatgtag aagcaagaaa gcaggttaac aggaagaaag ctttactgac      600

tcgtgtccag gagattcttg acaatgttca ggttagaaaa gcacctaatg ccagtgattt      660

tgatcagtgg gagatggaaa cagtttactc taattcagaa gtcagaaact tgaatgttcc      720

tgctacattt ccaaatagct ttccaagcca tacggaacac tctactgcag caaagcttga      780

taagatagct gggattttgc cattggataa tgaggaccaa tgtaaaactg atggaataga      840

cttagctaga gattcagaag gatttaattc tccgaagcaa tgtgatagtt ccaatattag      900

tcatgtagaa aatgaagctt ttccaaagac ctcttcagca accccacaag aaactcttat      960

ttctgatggt cccttctcag taaatgaaca acaggatcta ccacttttgg cagaagtcat     1020

cccagatccc tatgtaatga gtcttcagaa tctgatgaaa aagtcaaagg aatatataga     1080

aagagaacaa tctagacgca gtctgagagg tagtatcaac agaattgtta atgagagtca     1140

tttagacaaa gaacatgatg ctgttgaagt ggctgactgt gtaaaagaga aaggccagtt     1200

gacaggcaaa cactgtgtct cagttattcc tgacaaacca agccttaata aatcaaatgt     1260

tcttctccaa ggtgcttcca ctcaagcaag cagcatgagt atgccagttt tagctagctt     1320

ttcgaaagtg gacataccta tacgaactgg ccatcccact gttctagagt ctaattctga     1380

ttttaaagtt attcccactt ttgttaccga aaataatgtt atcaaaagtc ttacaggttc     1440

atatgccaaa ttacctagtc cagagccaag tatgagtcct aaaatgcacc gaagacgttc     1500

caggacatca tcagcgtgtc atatacttat aaataaccca ataaatgcct gtgaattaag     1560

ccctaaagga aaagaacagg caatggactt aattattcaa gatactgatg aaaacacaaa     1620

tgtgcccgaa attatgccaa agttaccaac tgatttagcg ggagtttgtt caagcaaggt     1680

ttatgtgggc aaaaatacat ctgaagtcaa agaagatgtg gttttaggta aatcaaatca     1740

ggtatgtcaa tcttcaggaa atcatttaga aaataaagtt actcatggac ttgttactgt     1800

ggaaggtcag ttaacatccg atgagagagg cgcacacata atgaacagta cctgtgctgc     1860

gatgccaaag ctgcatgaac catatgccag cagtcagtgt atagcaagtc caaactttgg     1920

aactgtgagt ggactcaagc cagccagtat gttagagaaa aactgcagtt tgcaaacaga     1980

actgaataag tcttatgatg taaaaaaccc ttctccttta ttgatgcaaa accagaatac     2040

gagacagcag atggacacac ctatggtgtc ctgtggaaat gaacaatttt tggataacag     2100

ttttgagaaa gttaaacgga gacttgattt agatattgat ggtttgcaaa aagaaaactg     2160

cccttatgtc ataacaagtg gaataactga acaagaaagg caacatttgc cagaaaaaag     2220

ataccctaag ggatctggct tcgttaacaa gaataaaatg ttaggaacta gttccaaaga     2280

aagcgaggag ttactaaaaa gcaagatgtt agcttttgaa gaaatgcgga agagactaga     2340

agaacagcac gcccagcaat tatcactact catagctgag caggaaaggg aacaagaaag     2400

actgcaaaag gaaatagaag agcaggagaa aatgttaaaa gagaagaagg caatgacagc     2460

ggaagcctct gagttggaca ttaacaatgc agtggaatta gaatggagaa aaataagtga     2520

ctctagtttg ctggaaacaa tgctgtctca agcggactca ctccatactt caaattcaaa     2580

tagttctggt ttcacaaatt ctgccatgca atatagcttt gtttctgcaa acgaagcacc     2640

attctacctc tggggatcat caactagtgg cttgaccaaa ctctcagtaa caaggccttt     2700

tggaagagcc aaaactagat ggtctcaagt ttttagtctg gaaatacaag caaaatttaa     2760

caaaataact gcagtggcaa aaggatttct tactcgtaga cttatgcaga cagataagct     2820

gaagcaactt cgacaaactg taaaagatac tatggaattc ataagaagtt ttcagtcaga     2880

agcaccatta aagagaggca ttgtttcagc tcaagatgct tcacttcagg aaagagtgtt     2940

agctcagttg cgagctgcct tgtacggtat tcatgacata ttctttgtaa tggatgcagc     3000

tgaaagaatg tctattctac atcatgatcg agaagttcgc aaagagaaaa tgctcaggca     3060

aatggataaa atgaaaagtc cacgagtggc tctttcagct gcaacacaga agtctcttga     3120

taggaagaaa tacatgaaag ctgctgaaat gggaatgcca aataagaaat ttctggttaa     3180

acaaaatcct tctgaaacaa gagtccttca gccaaaccaa ggacagaatg cacctgttca     3240

taggctactt agtagacaag ggagtatatg caggaaaaat ccaaagaaag cggccaaatg     3300

ttgcgacaat ttaagaagac aacattcatt aggataaaat ggggggaagg attattattc     3360

atgttatttt ccctgcccaa gactttattt aaccctggac tccgtttaca cagacaaagt     3420

gacatcagaa ggctgagcac ttatctggat catttggtca gtttggtaat tcctgctcca     3480

cacccctatt ttcctcttaa taatacgttt gggtgaagac aaattagtgt ttagtaattg     3540

catcatctct gtgcttacct atacaaacat aagtttattt tatatgccca gatgtctaca     3600

gagacccttt ttgtaaatgt caaggacatt tggatttact tttacagaat attgaaaaga     3660

taagacaaat tataaataag ttctaaaaca taaatttaat tcatctctgc atagtgattt     3720

ttgaatttga ttcaaaggga aattattgca gaagaatgcc tttccctcat tttataactt     3780

taaaaacttg gattaaccac tcaatgtcca ctttctttga cttacagtat aaccatgtag     3840

ccaattgtgg cccactaaaa tctacagaag ttaatgtggg tcaccatttt ggtcagaagc     3900

atacattcct gtcagacaac tagttgtctg acagaaatgt taggcttcat gtatgttacc     3960

ccagtactgt tagaaacatt tgtactaggt tataagatct ttctgtgaca ggtaacaaat     4020

ttggggaaga cagcacaatc ttcttgaatg tagctcttgg gaatgcatta ttacatccat     4080

ttctgtaaca taataatatg ttgcatgcag ttatattttc tatttagtct gtatattttg     4140

ttcttcatag tctgtttttt ctagcatgct tgatttagga gagaataaag ggctatataa     4200

taataaatcc agatttccgg ataagaatat tgcctggtta aaattctgca ttgcttaaag     4260

acacccatgt ttaagatttt tcatcactaa catatccatt aaaagtatca actggccagg     4320

cagggtggct cacgcctgta ctcccagcat tttgtgaggc caaggtgggt ggatcacctg     4380

aggtcaggag tttgagacca gcctgaccaa acatggcgaa accccatctg tactgaaaat     4440

acaaaaatta ggcatggtgg tgcatgcctg tagttccagc tacttgggag gctgagacag     4500

gcgaattgct tgaacctggg aggcagaggt tgcagtgagc tgagactgtg ccattgcact     4560

ccagtcgggt taacagagca agacactgtc tcaaaaaaaa aaaaaaaaaa aagtatcaac     4620

caacaaatgt taccaagata acgtgacttc atgagggaga atgtcactat taatttatca     4680

taccatttcc aaaaagggct ttgtgctttt cacataaaat tgagacagtg tatatttaat     4740

ctaatttaaa ttttaaagag atactggtat tttgaaaatg caacctatat atattcttaa     4800

tatcctttta agaatatgga gatgaagatt gttttctcca attttctgtg ccattttaaa     4860

tttaactttg acatccagct atagacagaa ataataagcc accctgggtg taaacttgat     4920

tttctttatt gagatgtatc atgtattgaa tgagtgaacc agaaaattag aagatggtca     4980

aaaaaagtcc aagttaccaa ttttttaaaa tttataggca aagtatcaaa ttgtcttctt     5040

aatatgataa actgtgcttt atcattctga aaactcagga tacagcttat tcatagcatt     5100

gtgggtctct ccagtaagaa agatgctaaa agttttgtgc actttttgtg tgtgtaatgc     5160

aaattagtta aaacaaatag ttttggagaa agttaaaact agctttagag taaggatgag     5220

aaacttgagt gtttttaatt taaagataaa agcctgtgtt ttacacattc ttttttggtg     5280

ttcatagctt cttctcatac aggtgccaga cactgtttgt gcttttgatg gatttttatt     5340

tatatacttt ttttgcttat ttttactttg agtggaatgt tcattaatgt aaattgtatt     5400

tatttttata cttttatttt cactagtttt gcttctaggc aaaaagcaaa ataaactttt     5460

catcttaaag aaaa                                                       5474


<210> 2424
<211> 1716
<212> DNA
<213> Homo sapiens

<400> 2424
ggcagaggcg caggcgcggt gcttcgcagc ccgcttccgg cctcacacct gccaagcatc       60

acacctgcca agcatcacac ctgccaagca tcacacctgc caagcatcac acctgcgatg      120

cctgcacgag ctgggtgcgg tccgcgcagc tgcagtaagg gggcgacccg gcgtctgtta      180

gtcggcggtt catctccttc gtgcctcgat gagctttaac gccattttcc tccattctct      240

ttcttcacct cttgagtttc caagatggca actatcaaga gtgaacttat taagaatttc      300

gcggaagagg aggccattca tcacaataag atctccattg taggaactgg atcggttggt      360

gtggcttgtg ctatcagcat cttattaaaa ggtttgagtg atgaacttgt ccttgtggat      420

gttgatgaag gcaaactgaa gggtgagaca atggatcttc aacatggcag cccttttatg      480

aaaatgccaa atattgtctc cagcaaagat tacctggtca ctgcaaactc caatctagtg      540

attatcacag caggtgcacg ccagaaaaaa ggagaaacac gccttgattt agtccagcga      600

aatgtatcca tctttaaatt aatgattccc aatattaccc agtacagtcc tcactgcaaa      660

ctgcttattg ttactaatcc agtggatatc ttaacttatg tagcctggaa gttgagtgga      720

tttcccaaaa accgtgttat tggaagtggt tgtaatctgg actctgctcg ttttcgttac      780

tttattgggc aaaggcttgg catccactct gaaagctgtc atgggctgat ccttggagag      840

catggcgact caagtgttcc tgtgtggagt ggtgtgaaca ttgctggcgt ccctctgaag      900

gatctgaacc cagatatagg aactgataaa gatcctgagc agtgggaaaa tgtccacaaa      960

aaagtgattt ccagtggcta tgagatggtc aaaatgaaag gttatacttc ttggggcatt     1020

agcctatctg tagctgattt aacagaaagt attttgaaga atcttaggag agtgcatcca     1080

gtttctaccc taagtaaggg cctctatgga ataaatgaag acatattcct tagtgtccca     1140

tgtatcctgg gagagaatgg tatcacagac ctcataaaag taaaactgac tcttgaagag     1200

gaggcctgct tgcaaaagag tgcagaaaca ctttgggaaa ttcagaagga gctcaagctt     1260

taaagttgct taaagctaat tctgtagatt gaagatgaaa tagtagttat ggaattgtat     1320

atgtcaaact tttgaataaa tttgaatttc taaaagttgg aaaaatagag gaaagagtga     1380

cctatttagt atagccttcc agcttttttt tttttctttt ttgggagggt ctcattctgt     1440

cacccaggct ggagtgcagt ggcacaatca tggctcactg caaccttgac ctcccgagct     1500

caggtgagcc tcccacttca gcctccagag taggtgggac cacatgcgtg tgcctccatg     1560

cctgcctaat ttttgtatct ttttgtagag atggggtttt gccatgtcat ccaagctggt     1620

tttgaactcc caaagtgctg agattacagg ggtgagccac tgtgcctggc cttagctttg     1680

atttagtatc cagatgatag atgacacttt tttttt                               1716


<210> 2425
<211> 1146
<212> DNA
<213> Homo sapiens

<400> 2425
aacagttgcc ttttcctctc acagaaggaa gatttcattt tgtttgagac gagaaaccaa       60

accacacacc aaagagaggg gtatgatggc taagaagccc ccaaaaccag cccctcgcag      120

gatcttccag gaaaggttaa agattactgc tctacctttg tactttgaag gttttttatt      180

aatcaagcgg tcaggatacc gggagtatga gcattactgg acagagttga gaggaactac      240

tcttttcttt tataccgaca aaaagagtat aatatatgtt gacaaattag acatagtaga      300

cctcacatgc cttactgagc agaattcaac tgaaaagaac tgtgcgaaat tcacccttgt      360

tttgccgaaa gaggaagtac aactgaagac agagaacaca gaaagtgggg aagaatggag      420

aggcttcatt cttacagtaa cagagctgtc agttccccaa aacgtgtcac tcctacctgg      480

gcaagtaatt aaactgcatg aagtcctaga gagagaaaag aaaaggagga ttgagacaga      540

gcagagtacg tccgtggaaa aagagaagga accaactgaa gattatgtgg atgtactgaa      600

ccctatgcca gcatgttttt atacagtgtc ccggaaagag gcaactgaga tgctccagaa      660

gaacccttct ttgggaaata tgatcctgag gcctggtagt gacagtagaa actactccat      720

cactattcgg caggagatag acattccaag aatcaagcac tacaaagtga tgagcgtagg      780

acaaaactac actattgaac tggaaaaacc tgtaacactc ccaaaccttt tcagtgtcat      840

tgattatttt gtgaaggaga ctcgaggaaa tttaagacca tttatatgtt caactgatga      900

aaacactggt caagaaccca gtatggaagg gagaagtgaa aagttgaaga aaaatccaca      960

cattgcatga aatacaatgt gaaagctcct ttgtatatct tggggaaaga ctatgtgaga     1020

cagagggaga aaacagccat tgacaactca aggagagagg cctcgggggg aaaaaaagat     1080

caacctggcc aaaaccttga aaatccggct tcttgacttg tgagaaaata aatttgtgtt     1140

ccttaa                                                                1146


<210> 2426
<211> 1907
<212> DNA
<213> Homo sapiens

<400> 2426
gccgcctgcg accggcagct cgttcgccgc actttggagg cttcggctgc ccctccgacc       60

cacgtagggc ccggacccgg gcctccttgt gaacagcgtg ccggcttcgc cccacgggtt      120

caccggctgg ctgggcttca agcgccgagg ccgccgcagt gaccccgccc ccgggccgag      180

gatgtgaggc gggccgggcg tccccacacc gggcccgggc gccgggagtg ggcgtctggg      240

cagcgccagg cgatggccct gctgctggtg ctcctcgcct cttggggcct ggggcagtga      300

gggggccggc gggcgtgggc cgagtggccg cgggcgccat ggagggggtg ctgtacaagt      360

ggaccaacta tctgagcggt tggcagcctc gatggttcct tctctgtggg ggaatattgt      420

cctattatga ttctcctgaa gatgcctgga aaggttgcaa agggagcata caaatggcag      480

tctgtgaaat tcaagttcat tctgtagata atacacgcat ggacctgata atccctgggg      540

aacagtattt ctacctgaag gccagaagtg tggctgaaag acagcggtgg ctggtggccc      600

tgggatcagc caaggcttgc ctgactgaca gtaggaccca gaaggagaaa gagtttgctg      660

aaaacactga aaacttgaaa accaaaatgt cagaactaag actctactgt gacctccttg      720

ttcagcaagt agataaaaca aaagaagtga ccacaactgg tgtgtccaat tctgaggagg      780

gaattgatgt gggaactttg ctgaaatcaa cctgtaatac ttttctgaag accttggaag      840

aatgcatgca gatcgcaaat gcagccttca cctctgagct gctctaccgc actccaccag      900

gatcacctca gctggccatg ctcaagtcca gcaagatgaa acatcctatt ataccaattc      960

ataattcatt ggaaaggcaa atggagttga gcacttgtga aaatggatct ttaaatatgg     1020

aaataaatgg tgaggaagaa atcctaatga aaaataagaa ttccttatat ttgaaatctg     1080

cagagataga ctgcagcata tcaagtgagg aaaatacaga tgataatata acagtccaag     1140

gtgaaataag gaaggaagat ggaatggaaa acctgaaaaa tcatgacaat aacttgactc     1200

agtctggatc agactcaagt tgctctccgg aatgcctctg ggaggaaggc aaagaagtta     1260

tcccaacttt ctttagtacc atgaacacaa gctttagtga cattgaactt ctggaagaca     1320

gtggcattcc cacagaagca ttcttggcat catgttatgc tgtggttcca gtattagaca     1380

aacttggccc tacagtgttt gctcctgtta agatggatct tgttggaaat attaagaaag     1440

taaatcagaa gtatataacc aacaaagaag agtttaccac tctccagaag atagtgctgc     1500

acgaagtgga ggcggatgta gcccaggtta ggaactcagc gactgaagcc ctcttgtggc     1560

tgaagagagg tctcaaattt ttgaagggat ttttgacaga agtgaaaaat ggggagaagg     1620

atatccagac agccctaaat aatgcatatg gtaaaacatt gcggcaacac catggctggg     1680

tagttcgagg ggtttttgcg gtgtaggaat gtgggtgtag acggaactcc agaaaccatc     1740

atggaccatg aggcaactct gaggatggaa gccacacact aaggacggta aagcagaaag     1800

aagagctgaa accctgatga taaagaagca gccaattccg tcctgcactg cccacctcca     1860

gatctcattc atgtgaaaca aagagaaact ttatcttgtt caagtca                   1907


<210> 2427
<211> 2837
<212> DNA
<213> Homo sapiens

<400> 2427
agctcgttcg ccgcactttg gaggcttcgg ctgcccctcc gacccacgta gggcccggac       60

ccgggcctcc ttgtgaacag cgtgccggct tcgccccacg ggttcaccgg ctggctgggc      120

ttcaagcgcc gaggccgccg cagtgacccc gcccccgggc cgaggatgtg aggcgggccg      180

ggcgtcccca caccgggccc gggcgccggg agtgggcgtc tgggcagcgc caggcgatgg      240

ccctgctgct ggtgctcctc gcctcttggg gcctggggca gtgagggggc cggcgggcgt      300

gggccgagtg gccgcgggcg ccatggaggg ggtgctgtac aagtggacca actatctgag      360

cggttggcag cctcgatggt tccttctctg tgggggaata ttgtcctatt atgattctcc      420

tgaagatgcc tggaaaggtt gcaaagggag catacaaatg gcagtctgtg aaattcaagt      480

tcattctgta gataatacac gcatggacct gataatccct ggggaacagt atttctacct      540

gaaggccaga agtgtggctg aaagacagcg gtggctggtg gccctgggat cagccaaggc      600

ttgcctgact gacagtagga cccagaagga gaaagagttt gctgaaaaca ctgaaaactt      660

gaaaaccaaa atgtcagaac taagactcta ctgtgacctc cttgttcagc aagtagataa      720

aacaaaagaa gtgaccacaa ctggtgtgtc caattctgag gagggaattg atgtgggaac      780

tttgctgaaa tcaacctgta atacttttct gaagaccttg gaagaatgca tgcagatcgc      840

aaatgcagcc ttcacctctg agctgctcta ccgcactcca ccaggatcac ctcagctggc      900

catgctcaag tccagcaaga tgaaacatcc tattatacca attcataatt cattggaaag      960

gcaaatggag ttgagcactt gtgaaaatgg atctttaaat atggaaataa atggtgagga     1020

agaaatccta atgaaaaata agaattcctt atatttgaaa tctgcagaga tagactgcag     1080

catatcaagt gaggaaaata cagatgataa tataacagtc caaggtgaaa taaggaagga     1140

agatggaatg gaaaacctga aaaatcatga caataacttg actcagtctg gatcagactc     1200

aagttgctct ccggaatgcc tctgggagga aggcaaagaa gttatcccaa ctttctttag     1260

taccatgaac acaagcttta gtgacattga acttctggaa gacagtggca ttcccacaga     1320

agcattcttg gcatcatgtt atgctgtggt tccagtatta gacaaacttg gccctacagt     1380

gtttgctcct gttaagatgg atcttgttgg aaatattaag aaagtaaatc agaagtatat     1440

aaccaacaaa gaagagttta ccactctcca gaagatagtg ctgcacgaag tggaggcgga     1500

tgtagcccag gttaggaact cagcgactga agccctcttg tggctgaaga gaggtctcaa     1560

atttttgaag ggatttttga cagaagtgaa aaatggggag aaggatatcc agacagccct     1620

aagtgtagga atgtgggtgt agacggaact ccagaaacca tcatggacca tgaggcaact     1680

ctgaggatgg aagccacaca ctaaggacgg taaagcagaa agaagagctg aaaccctgat     1740

gataaagaag cagccaattc cgtcctgcac tgcccacctc cagatctcat tcatgtgaaa     1800

caaagagaaa ctttatcttg ttcaagtcac tttagtcaag atttttatta tcagatgaat     1860

gcaatttcta attgatacac cttaaaattt tcaacatgta cacctgattt aacaaaatct     1920

agaattaagt caatacttct acatgcatta tagaccaaag gtcactgcta taagaacttt     1980

gggtatatag tcaaattcct cacattttta gaaacttgtt tattcattgc atccctcccc     2040

catctcactc tctcacacac tcacatattt attttctcag atccttataa gttcataaga     2100

catatgtcct tattccattt ttacagatga gaaaactggg gtttgcaggg gttaagtaac     2160

ttatccaaga tcacacaatt aattagtggc gaagtcataa tttgaagtct ttctaatgcc     2220

caaatgtttc cattgtgtca catatcggag ctgtgctctt tccatcagcc agtttcccat     2280

tatcatagct gatgacatgc acacccacca tctggggcag gctttagtac agcactctgt     2340

gccatcatcc agatcaccaa atcttagtaa atggacgtgt cataagagat aaggctgcca     2400

tagaatcaca gcagcttctg gcttagtaaa ttacctggat acacaccttt tcctagagga     2460

aatcccacat cttcgtagga gatctggtgt aatgctcttg ggacctctct ctagaggatg     2520

agctagtatc actgggtcct agtaagtttc agcaaatata atagagacag aactgtcatc     2580

attatcagaa aagaaacaga gaaaaatgtt aaaacaatgg ttttgtgacc ttaaagtctg     2640

tgttagtccc ttagcaccac cgctgagatt ttgctgaaag ggacgttttg tgtgttgggc     2700

ttcactgaag gaagcccctg aaagtgttca gaaataggga aaatgagaaa ctgttccagc     2760

tgaaaatacg ggcaaggggg aatcattgaa gaagacagaa tattgaagtg ttcaaatgaa     2820

taaagaagct aaaaact                                                    2837


<210> 2428
<211> 1886
<212> DNA
<213> Homo sapiens

<400> 2428
aatgacatga cagccattcc gtggccaggg acaccactgc ccaagctgga gaccacgagg       60

attcagggac tgaagccagc atgggaattc ctggtttgag atcagagtcc tgagtacctc      120

gtgggaactt gggcactcat ccgcaggagg tctagacccc cagagaattc cttgagtcta      180

aggcacaggc ccaacatgtg tagcaccagt gggtgtgacc tggaagaaat ccccctagat      240

gatgatgacc taaacaccat agaattcaaa atcctcgcct actacaccag acatcatgtc      300

ttcaagagca cccctgctct cttctcacca aagctgctga gaacaagaag tttgtcccag      360

aggggcctgg ggaattgttc agcaaatgag tcatggacag aggtgtcatg gccttgcaga      420

aattcccaat ccagtgagaa ggccataaac cttggcaaga aaaagtcttc ttggaaagca      480

ttctttggag tagtggagaa ggaagattcg cagagcacgc ctgccaaggt ctctgctcag      540

ggtcaaagga cgttggaata ccaagattcg cacagccagc agtggtccag gtgtctttct      600

aacgtggagc agtgcttgga gcatgaagct gtggacccca aagtcatttc cattgccaac      660

cgagtagctg aaattgttta ctcctggcca ccaccacaag cgacccaggc aggaggcttc      720

aagtccaaag agatttttgt aactgagggt ctctccttcc agctccaagg ccacgtgcct      780

gtagcttcaa gttctaagaa agatgaagaa gaacaaatac tagccaaaat tgttgagctg      840

ctgaaatatt caggagatca gttggaaaga aagctgaaga aagataaggc tttgatgggc      900

cacttccagg atgggctgtc ctactctgtt ttcaagacca tcacagacca ggtcctaatg      960

ggtgtggacc ccaggggaga atcagaggtc aaagctcagg gctttaaggc tgcccttgta     1020

atagacgtca cggccaagct cacagctatt gacaaccacc cgatgaacag ggtcctgggc     1080

tttggcacca agtacctgaa agagaacttc tcgccatgga tccagcagca cggtggatgg     1140

gaaaaaatac ttgggatatc acatgaagaa gtagactgaa atatcagatt tgtcatcagg     1200

aatactcttt gtctactgtg gtcctgtgca cgttggcctc agatggacta caggagatta     1260

caacgtacaa ggcagatgga gcattgacgt tttcaaaacc attattcctg tgactggaga     1320

ggcatcagga gaggtctcgt tcgtctccag ctcataaaat gtagcagcat catccttgac     1380

agtgatgttt ttcaggccct ccattgagaa cctgaggaaa tctgtaaaga taagtggtga     1440

tgttgtttca aacgttcaga acagatacca tcatcctgcc tttgttagct gctgtaggga     1500

aagtgcgtta cagatgtctg ctgacctcac aagagtgaaa agataaactg tgcatgtgtt     1560

tccacttccg tttctagtac tatttatttt taaactacac ttggggtggc ctaataccta     1620

ggaagatgtt gctattcacg ttagtaaaca gcctaaagaa actcttaggt ttactgctac     1680

atccatttgt ttggagaggt aactgttgtc tgtgcctttt tgaaaaactt ccatttggta     1740

caaaattttt actccaacac cccctcaacc cttttctcag ggaccacacc tcttcttccc     1800

aaggtccctg ggacttcctc attctttgtg gtagtacaat gattggtagc aggtaaaata     1860

aatacataga aagactactg tcaaaa                                          1886


<210> 2429
<211> 7743
<212> DNA
<213> Homo sapiens

<400> 2429
gggcggtgcg gtgcggaagc ggaagtgaag ggtgcgcttg gcggcggcgg cgggagctgc       60

ggagtcggga atcaaaacaa agggcctggg gggggcgggg ggaaggcggc ggggccggaa      120

tgtgagcgga ggtggagccg gcggcagagg gtggaagaat gaaagaaaag aaagatgaaa      180

ggatgttgaa tcactttgca tggctgtatg atggaaggaa acggaactga gaactcctgc      240

agtagaacac gtggatggct tcaacaagat aatgatgcta agccatggct ttggaaattc      300

tctaattgct tttctcgtcc tgagcagacg ctgccacata gtccccaaac gaaagagtac      360

atggagaaca agaaagttgc tgtggaacta aaggatgtac catcacccct tcatgctggc      420

tctaagcttt ttccagcagt cccacttcct gatattcgtt ctcttcagca gcctaaaata      480

cagctttctt ctgtccccaa agtaagctgc tgtgctcatt gccctaatga accctccact      540

tcgccaatgc gttttggtgg tggtggtggc ggtagcggag gtaccagtag cttgattcac      600

ccgggcgcac tgttagactc gcaaagcacc aggacaatca cgtgtcaggt agggtcaggg      660

tttgctttcc agtctgcatc ttcactccag aatgcctcag ctaggaacaa tttggcaggc      720

attgcaagtg actttcccag catgtgtcta gagagtaacc tgtcttcctg caaacacctg      780

ccctgttgtg gaaaactcca cttccagtca tgtcatggta atgtgcacaa gctgcatcag      840

tttccgagtc tgcagggctg cacctccgct ggctatttcc cctgttctga tttcacaagc      900

ggggctccag ggcatttgga agagcacatt tcacagtcgg agctaacgcc tcacttgtgc      960

accaactctt tgcaccttaa tgtggtacct ccggtttgtt taaagggctc actttactgc     1020

gaagactgtc taaacaagcc agcaagaaat agcataatcg atgcggctaa agtctggcca     1080

aatataccac ctccaaatac tcaacctgca cctcttgctg tccctctgtg taatggctgt     1140

ggaaccaaag gaacagggaa ggagaccacg ttgttattgg cgaccagtct aggcaaagct     1200

gcttcaaaat ttgggtcacc agaagttgca gtagctggac aggtgctaga aaacttaccc     1260

cccattggag ttttttggga tattgaaaac tgctccgttc cctctggccg gtcagcaact     1320

gctgttgtgc aaagaatccg tgagaagttt tttaaaggcc acagagaagc agaattcatc     1380

tgtgtatgtg acatcagtaa agaaaacaag gaagttattc aagagctgaa taattgccag     1440

gtaaccgttg cccacatcaa tgctactgca aagaatgccg ctgatgataa actgcggcag     1500

agtctccgca gatttgcaaa tacacacact gctccagcca cagtggttct tgtgtcaact     1560

gatgtcaatt ttgcattgga acttagtgac ctgagacaca ggcatggttt ccacattatt     1620

ttggtccata aaaaccaggc ctcagaagca ctgctgcatc atgctaacga gctgatcaga     1680

tttgaagagt tcatttccga cttgcccccc aggttaccac taaaaatgcc acagtgccac     1740

actctgctct atgtttataa cctaccagca aataaggatg gcaagagcgt cagcaacagg     1800

ctcagacgcc tgtccgataa ttgtggtggg aaagtgctga gtatcacagg ctgcagtgca     1860

attctccgct tcataaacca agatagtgca gagcgcgctc agaagcgaat ggaaaacgaa     1920

gatgtctttg gtaataggat cattgtgtca tttactccaa aaaatagaga actctgtgaa     1980

acaaagagtt caaatgcaat tgctgataaa gtgaagtctc ccaaaaaact taagaatcca     2040

aaattgtgcc tcatcaaaga tgcaagtgaa caatcttcca gtgccaaagc cacgcctgga     2100

aaagggtcac aggcaaattc tggatctgct acaaaaaata caaatgttaa aagtttacag     2160

gagctgtgcc gcatggagtc aaaaactggt catagaaaca gtgagcacca gcaaggtcac     2220

ctgaggctgg tcgtacccac tcacggtaac tcaagtgctg cagtgtcgac gccgaaaaac     2280

tcgggggtgg cagaacccgt ttacaaaacc agtcagaaaa aggagaacct cagtgcccga     2340

agtgttacca gttctcctgt agagaaaaaa gataaagagg agactgtatt ccaagtgagt     2400

tacccgtctg cttttagcaa gttagttgca tccaggcaag tcagtcctct gctcgcatct     2460

cagtcttggt cttctaggag tatgtctcca aaccttttaa acagagcatc cccgcttgct     2520

ttcaacattg caaattcgag cagcgaagcc gactgcccag acccatttgc aaatggtgct     2580

gatgtccaag tcagcaacat agactacaga ttatcccgga aggagctgca gcagctcctg     2640

caggaagcat ttgccaggca tggcaaggtg aagagtgttg agctcagccc ccatacagat     2700

tatcaactca aggctgttgt gcaaatggaa aacttacaag atgcgatcgg tgcagtgaat     2760

agcctccaca gatacaaaat tggcagcaaa aagatcctgg tctcacttgc caccggggct     2820

gccagcaaat cactctcttt actgagtgca gaaacaatgt ctgttcttca ggatgcccct     2880

gcctgttgcc tgcctctgtt taaatttaca gatatctatg aaaaaaagtt tggacacaag     2940

ttgaatgtgt cagatctata taaattaaca gacacggtcg caatccgtga acaaggaaac     3000

ggacggctgg tgtgtctcct acccagcagt caggcccgcc agagcccctt ggggtcttcc     3060

cagtcacacg acggctcctc cacgaattgc agcccaatta tatttgaaga gttagaatat     3120

cacgagcctg tctgcagaca gcattgttcc aataaggatt tcagcgaaca tgaatttgat     3180

ccagactctt acaagattcc ttttgtgatt ctttctttga agacatttgc gccccaggtt     3240

cacagtcttc tccagaccca cgagggcacc gtgcctttat tgagctttcc agattgttac     3300

attgcagagt ttggcgatct agaagtagtg caagaaaacc aaggaggtgt tcccttagaa     3360

cacttcatta cctgtgttcc aggtgtaaac attgccactg ctcagaatgg catcaaagtg     3420

gttaaatgga ttcacaacaa gcccccgcct cccaacactg acccttggct tctgcgttcg     3480

aagagtcctg taggtaaccc ccagctgatc cagttcagta gagaagtgat tgacttgctg     3540

aaaagccagc catcttgtgt catacccatc agtcatttca tcccatccta tcaccatcat     3600

tttgcaaagc agtgccgagt gtcagactac ggatactcca agctgattga gttattagaa     3660

gcagtgcctc atgtattgca gattcttgga atgggctcca aacgtctgct gacccttacc     3720

cacagggccc aggtgaagcg ctttactcag gatttactaa aacttctcaa atcccaggcc     3780

agcaaacagg tcattgtgag agaattctca caggcttatc actggtgttt ctcaaaggac     3840

tgggatgtca ctgaatatgg tgtttgtgag ttgattgaca tcgtatcaga gattccagac     3900

acaaccatct gcttgtccca acaagataat gaaatggtga tttgtatccc caaaagagaa     3960

cgcactcagg atgaaataga aaggacaaaa cagttctcca aggatgtcgt tgatttgctg     4020

cgtcaccaac cccatttccg gatgcccttt aataaattta tcccttctta ccatcaccac     4080

tttggccggc agtgcaaact tgcgtactat gggtttacca aactacttga actttttgaa     4140

gccatacctg atactttaca agtattggaa tgtggagaag aaaagatcct tactctgaca     4200

gaggtggagc ggttcaaagc tctagctgcc cagtttgtta aactccttcg gtcccaaaaa     4260

gataactgcc ttatgatgac agatctcctt acagaatatg ctaaaacttt tggttataca     4320

tttcgtctcc aagactatga tgtcagttcc atttcggctt taactcagaa actctgccat     4380

gtcgtgaagg ttgccgatat agaatctggc agacagattc agctgatcaa ccgaaagtct     4440

ctgcgatctc tcactgccca gttgctggta ttgttgatgt cttgggaagg aaccacccat     4500

ctttctgttg aggagctcaa gagacattac gaaagtaccc acaacactcc ccttaacccc     4560

tgtgaatatg gattcatgac cttgaccgaa ctgctgaaga gcctgccata cttggttgag     4620

gttttcacta atgataagat ggaagaatgt gtgaagctca caagtctgta tttgtttgca     4680

aagaatgtgc ggtctttact tcatacttac cactaccagc agattttcct tcatgagttt     4740

tccatggcct ataccaagta tgtcggagaa actctgcagc ccaagaccta cggccacagc     4800

agcgtggagg agctcttggg agcaattcca caggtggtct ggataaaagg acatggtcat     4860

aagagaattg tagtgttaaa aaatgacatg aaaagtcgtt tgagttcact cagtctctcc     4920

cctgccaatc atgaaaacca gccctcggag ggcgagcgca tcctggaggt gcccgaatcg     4980

cacacagcct cggaactcaa gcttggagct gacggcagtg ggcccagtca cacagagcag     5040

gagcttctcc gcctgaccga cgactccccc gtcgacctcc tgtgtgcgcc tgtcccctcg     5100

tgcctgccgt cccctcagct gagaccagac cccgttatcc tccaatctgc tgatctcatt     5160

cagtttgagg agcgccctca agagccttct gaaattatga ttttaaacca agaagaaaaa     5220

atggagattc caataccagg aaagagcaaa actctgacct ctgactccag ctcgtcctgc     5280

atctcagcag ctgtccccgt gcctccctgc ccctcctcgg aaacctccga gtcactgctc     5340

agcaaggacc ccgtggaaag cccggccaaa aagcaaccca aaaatagagt caaattggca     5400

gccaactttt ccttagcacc tataaccaag ctttaactcc catttggaat atagaattag     5460

gatgggaaaa cactgtctga ttctgcacac aaaagtgggt ttcaaaaata catccttttc     5520

tgtgtcatga aaaccccccg aagccattga cttcatctta cctgtgttct atcatgtttt     5580

tcttttccat tgaacacagc tttgagctga agtctttctt ttcttcttcc tttttctttc     5640

ttttttcaat tatttgaaga acttgtggca tttgttaaag aatccttaat atattttacc     5700

aaatttttag taactattat gaaatacaat ggtgttccaa aagaagaaag cactaaaaac     5760

tcaactagca ggaagcggtt ttgcttccat tgagccacgt cggtggtgtc atcctacatg     5820

tagcataata gagtctctca gcctttgctt actggtgttt ccgacagtat taacccagtg     5880

cgtggcatgt ctttgaagca aagcctgtcc cgctagcctg tgtgttcaca caccaaagga     5940

gaagggtagg cgaggggttc ggagtgtatt ttcaggttgg aatgtgaagg ttcctggctt     6000

ccatgtgact tgtaagtgtg ccttgttttt tatttaaact atgtctgtag ttgacaaaag     6060

tggcttcatc acaaattttt ttaaacgttt ctactttggg gttccattta ggagctttct     6120

agaaagttga ggatgtttga agcttccctt ctgtgttcca gtttgatatg ggttaggtta     6180

aggaaaagga gatggtctcg atgtcatgga tttaaagtca gcatttggat tacaacacac     6240

attattgtgt gtcgagaggc agcattggaa agagcctgat tttctaaaat atgcatcaag     6300

tgcataaatt acaaatcaga gctgagtggg gaggtgcttc agcagcagcg ggatcaatac     6360

gatttccact gggaagagac aggaattcta cctacacata ggaaggccaa ggttgatcca     6420

cttaaccttg ttattgtaat tttaaagctg gtatcggtag ctgggaagct ttatgtgtgt     6480

gtatgtcagc tcagcatctt ttaatcgtgt ctgattttac tctcgttact tctcgctgtt     6540

ggaagcatct ctgggtttct tgtggcgtct ggtgtggaat ggccttcctc tctaggtgcc     6600

tgaggtgtcc gctgacgggt ggcctctcac ccccctctag agaaacctga catttacaat     6660

ggattgtatt tgtccggcaa aaaaggcgga ttcattcata gagcagaaag aacctgttgg     6720

cgtaaggtct tccactagtt agatggtttc ttttggggaa atgtttatat ttggtaactt     6780

ctagaaagcc agaaaatgga ctctgatttc atagcatttt gataaaatgc cacaaaataa     6840

gggctataga gagattttta caagtcagat tttttgttcc ccaaatcttt taaatgaagc     6900

cagtgactcc cagttctcaa cacatggccc cagtcaagac agaacaccat ggaaaaaacc     6960

ctgtaagtat tatggcactc tccgaatcct cctgaaggca tttcctctac agacatagtg     7020

ttacaggaag tgaaatgcaa atgtgcaatt ttttttaaag gagcttttaa acaaagtaat     7080

aataattggt gttgagaaca tcagttgcct tattctaaga tttcataagg ctgagtttgc     7140

acgcttggac ttcagttctg ctagcatgta aagagtggtg gactttaaaa ccgtaagagg     7200

tatcattaca agtcacctgg aacagactca aagaacaggt tctttgggca acagacaaag     7260

aagaatcaag ttctgtgctg tcccgtgagt gtgtctgagt accattcact ggagttgctg     7320

cttaggtctg ggacgtgtgt gtgactctta acaattgctg tctgaaaatg agagagaaga     7380

cttcggaagc acattgtgtt cataatgtac tccacaatgg ccagtccaat tgctatctat     7440

ttttttatcc agaggcttaa ttaaatgatg tggtaaaatg atgtttgagc attaagacaa     7500

tgtaattctt tatttctggg tggaaagata taccggatta aatttatctg tttaaaaaaa     7560

tgacaaaagt tatcaccaaa accccctttc ccatcttgca ctgtttgttt tggattgggt     7620

ttgggggaaa gagatgtttt tcttagttgt ctactttgtt tgaacacttt tgttgtggtt     7680

caagtgctgt tttgtgtgtt gggaccaaac agttgtcaat aaactttaca agcgagcatc     7740

tat                                                                   7743


<210> 2430
<211> 1026
<212> DNA
<213> Homo sapiens

<400> 2430
aatgacatga cagccattcc gtggccaggg acaccactgc ccaagctgga gaccacgagg       60

attcagggac tgaagccagc atgggaattc ctggtttgag atcagagtcc tgagtacctc      120

gtgggaactt gggcactcat ccgcaggagg tctagacccc cagagaattc cttgagtcta      180

aggcacaggc ccaacatgtg tagcaccagt gggtgtgacc tggaagaaat ccccctagat      240

gatgatgacc taaacaccat agaattcaaa atcctcgcct actacaccag acatcatgtc      300

ttcaagagca cccctgctct cttctcacca aagctgctga gaacaagaag tttgtcccag      360

aggggcctgg ggaattgttc agcaaatgag tcatggacag aggtgtcatg gccttgcaga      420

aattcccaat ccagtgagaa ggccataaac cttggcaaga aaaagtcttc ttggaaagca      480

ttctttggag tagtggagaa ggaagattcg cagagcacgc ctgccaaggt ctctgctcag      540

ggtcaaagga cgttggaata ccaagattcg cacagccagc agtggtccag gtgtctttct      600

aacgtggagc agtgcttgga gcatgaagct gtggacccca aagtcatttc cattgccaac      660

cgagtagctg aaattgttta ctcctggcca ccaccacaag cgacccaggc aggaggcttc      720

aagtccaaag agatttttgt aactgagggt ctctccttcc agctccaagg ccacgtgcct      780

gtagcttcaa gttctaagaa agatgaagaa gaacaaatac tagccaaaat tgttgagctg      840

ctgaaatatt caggagatca gttggaaaga aaggaaaaag aatgggagga gtcagcaaag      900

accaagataa aaatggcact tctctggagg agcagtggtg gtggacccag agttctgagt      960

atacctgagg catttatgaa gaacagcttc actctcaccc cacctggctt ctcagaacac     1020

aattag                                                                1026


<210> 2431
<211> 1857
<212> DNA
<213> Homo sapiens

<400> 2431
ggtgccaccc ctccccccgg cggccccgcg cgcagctccc ggctccctcc cccttcggat       60

gtggcttgag ctgtaggcgc ggagggccgg agacgctgca gacccgcgac ccggagcagc      120

tcggaggcgg tgaataatag ctcttcaagt ctgcaataaa aaatggcctc caacaaaact      180

acattgcaaa aaatgggaaa aaaacagaat ggaaagagta aaaaagttga agaggcagag      240

cctgaagaat ttgtcgtgga aaaagtacta gatcgacgtg tagtgaatgg gaaagtggaa      300

tatttcctga agtggaaggg atttacagat gctgacaata cttgggaacc tgaagaaaat      360

ttagattgtc cagaattgat tgaagcgttt cttaactctc agaaagctgg caaagaaaaa      420

gatggtacaa aaagaaaatc tttatctgac agtgaatctg atgacagcaa atcaaagaag      480

aaaagagatg ctgctgacaa accaagagga tttgccagag gtcttgatcc tgaaagaata      540

attggtgcca cagacagcag tggagaattg atgtttctca tgaaatggaa agattcagat      600

gaggcagact tggtgctggc gaaagaggca aatatgaagt gtcctcaaat tgtaattgct      660

ttttatgaag agagactaac ttggcattct tgtccagaag atgaagctca ataattgttc      720

acattgttct tttatatata tttatatata tatataaaaa ttgggtctta gattttgatt      780

tactagtgtg acaaaataac tacatcctaa tgaaaatcaa gtttgatatg tttgttttga      840

aagtagcgtt ggaagagttg ttgggggttt tttgcatcca tagcactggt tactttgaac      900

aaataaataa aagctttctg tagttgcttc ctttatcaga aaagaacatt tgataccatg      960

gtatatcatt tcctcttcat taaagaacag cttttctaaa tgttggggga aatgtccata     1020

gtcattactc agtcaaaact tgtgttctca tgagcctaag gaccattcta gatttattac     1080

gtgttttttg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tccataaaat gcatatgtaa     1140

attttttttt gtttttaagc attcacccaa acaaaaaaat cacaggtaaa cccatgtttc     1200

tgagatgcca ttattccaag caaaataaga gataatccct tcaagttaaa ttgaaaattt     1260

tcctgaaacc atacatttca agtgaaataa gtaattctag ataggacaat ttaaattgga     1320

taattttaaa gtgtctataa ttgcagtggt ttatttgcaa aattcctaaa aggaaaaatt     1380

ttatcactgc catcacagca ggtttcctca tccagatgag gaaactagac aaatgctagt     1440

gtgttttaac tagctaaaca aaactaagtt aaatgaacat ttaaaagttt ccctagcggg     1500

ccattcctta gcaaaatgtt ggaatccctg ttgctacatt gactaaaagg tcatgatgaa     1560

tggaatatgt aagacttggc tcatagaaac ctaatcagat ggttagaggt gttggcagtt     1620

taggacctgc tgtcataaat gtgtgaacaa ccttttgtaa cctaacctat tgacctgcat     1680

gttttttctt taccccaatt cattacatgg aggctcaatc ttgagtttgc tttactggtt     1740

cagcaaaagc caggaagaac aactttgtag taatcaaaat gttatccaac tgtatattgt     1800

ttactttatt gtaaatactg gtgaacagtg gttaataaat agttttatat tccttta        1857


<210> 2432
<211> 1384
<212> DNA
<213> Homo sapiens

<400> 2432
agtcggcggc cggactggga agatggacgc agctactctg acctacgaca ctctccggtt       60

tgctgagttt gaagattttc ctgagacctc agagcccgtt tggatactgg gtagaaaata      120

cagcattttc acagaaaagg acgagatctt gtctgatgtg gcatctagac tttggtttac      180

atacaggaaa aactttccag ccattggagg ttgtcgggac atttcactct ccagtaaatg      240

tggcccttgg cgttactgag tcctaagagg ggggacaggc cccacctcgg acacaggctg      300

gggctgcatg ctgcggtgtg gacagatgat ctttgcccaa gccctggtgt gccggcacct      360

aggccgagat tggaggtgga cacaaaggaa gaggcagcca gacagctact tcagcgtcct      420

caacgcattc atcgacagga aggacagtta ctactccatt caccagatag cgcaaatggg      480

agttggcgaa ggcaagtcca taggccagtg gtacgggccc aacactgtcg cccaggtcct      540

gaagaagctt gctgtcttcg atacgtggag ctccttggcg gtccacattg caatggacaa      600

cactgttgtg atggaggaaa tcagaaggtt gtgcaggacc agcgttccct gtgcaggcgc      660

cactgcgttt cctgcagatt ccgaccggca ctgcaacgga ttccctgccg gagctgaggt      720

caccaacagg ccgtcgccat ggagacccct ggtacttctc attcccctgc gcctggggct      780

cacggacatc aacgaggcct acgtggagac gctgaagcac tgcttcatga tgccccagtc      840

cctgggcgtc atcggaggga agcccaacag cgcccactac ttcatcggct acgttggtga      900

ggagctcatc tacctggacc cccacaccac gcagccagcc gtggagccca ctgatggctg      960

cttcatcccg gacgagagct tccactgcca gcacccgccg tgccgcatga gcatcgcgga     1020

gcttgacccg tccatcgctg tggggttttt ctgtaagact gaagatgact tcaatgattg     1080

gtgccagcaa gtcaaaaagc tgtctctgct tggaggtgcc ctgcccatgt ttgagctggt     1140

ggagctgcag ccttcacatc tggcctgccc cgacgtcctg aacctgtccc tagattcttc     1200

tgatgtagag cgactggaaa gattcttcga ctcagaagat gaagactttg aaatcctgtc     1260

cctttgaaaa tcctggggtc gggggtggca cctgtgagag cctggggctc ctggtgccgc     1320

tgcgtttcat ccatcccgcc cgctcgcctg ccgagggctg cgccccgtgc tgcctccccc     1380

caga                                                                  1384


<210> 2433
<211> 1306
<212> DNA
<213> Homo sapiens

<400> 2433
tgcctccggg tcgcggtcat tttgagcccc tgtctggatg acttcttgcg gctgttctac       60

ccctccccct ccccgcggta ccttgcactt ttctccctcc ctgccccctc tcgagtccac      120

cctccgggcc ttctgcccct gatcgcttgg ttttccttgc agtcgcctgc tgctgtcgtc      180

gggaggaaag atgaatggga gggctgattt tcgagagccg aatgcagagg ttccaagacc      240

aattccccac atagggcctg attacattcc aacagaggaa gaaaggagag tcttcgcaga      300

atgcaatgat gaaagcttct ggttcagatc tgtgcctttg gctgcaacaa gtatgttgat      360

tactcaagga ttaattagta aaggaatact ttcaagtcat cccaaatatg gttccatccc      420

taaacttata cttgcttgta tcatgggata ctttgctgga aaactttctt atgtgaaaac      480

ttgccaagag aaattcaaga aacttgaaaa ttcccccctt ggagaagctt tacgatcagg      540

acaagcacga cgatcttcac cacctgggca ctattatcaa aagtcaaaat atgactcaag      600

tgtgagtggt caatcatctt ttgtgacatc cccagcagca gacaacatag aaatgcttcc      660

tcattatgag ccaattccat tcagttcttc tatgaatgaa tctgctccca ctggtattac      720

tgatcatatt gtccaaggta gaaacttctc ttgaaatgaa tttcaacatt ttatggtcca      780

actcaaagta aacaagtatg gagatacttg ggatgagtga aaaattacat cattggacat      840

gaaggagttt caacatccag cttcatctag gtggtcatga ttacctgcat gctttgagct      900

cagcagcagt cttcataaac acatttaaaa caagatcctg ggtttttgtg gtttgacttc      960

tatggtgttt taaaaaaaca cagattttta gtgttaatat tgtgtaaatg tactcacctt     1020

agggattcat ttgaatgatg gtattatacc atgattgtat acagtttgtg aaattgttgc     1080

aagggcaaag ataactctta aaaaaccgtc gagattacaa tgctctagaa tcagcatata     1140

agaaaataaa tgatatctgc atgttgaatt ggggtggatg gggggagcaa gcataatttt     1200

taagtgtgaa gctttgcatc aagaaattat taaaaagctt tttttctcca gtattttctg     1260

tattatctta atgtttatgg caaataaaat gtaaaggaac atgcaa                    1306


<210> 2434
<211> 1304
<212> DNA
<213> Homo sapiens

<400> 2434
aacagatttt aactctgaaa agccatttcc agtgtctata gactattgtg agcctggaga       60

agtagcattt agttgggata gcttcactag agctgcctgc caaagacttc cttccacagg      120

atcttgtcgc accagcaact gacaggagct tgggagctcg ggagcttggg agagggctta      180

tgtttttaat aatgtagctg tcagttcgaa gcctggaaat gttgaccctc aaagggcata      240

aaatcttgtt attttaattt gcatctggga gaatgtctga gcaaggagac ctgaatcagg      300

caatagcaga ggaaggaggg actgagcagg agacggccac tccagagaac ggcattgtta      360

aatcagaaag tctggatgaa gaggagaaac tggaactgca gaggcggctg gaggctcaga      420

atcaagaaag aagaaaatcc aagtcaggag caggaaaagg taaactgact cgcagccttg      480

ctgtctgtga ggaatcttct gccagaccag gaggtgaaag tcttcaggat cagactctct      540

gaaaactgca aatggaaagg aattcaaaag aatttagatt aaaagttaaa taaaaagtag      600

gcacagtagt gctgaatttt cctcaaaggc tctcttttga taaggctgaa ccaaatataa      660

tcccaagtat cctctctcct tccttgttgg agatgtctta cctctcagct ccccaaaatg      720

cacttgccta taagaaacac aattgctggt tcatatgaaa cttaggaaat agtgaataag      780

gtgcatttaa ctttggagaa atacttttat ggctttggtg gagatttctc aatactgcaa      840

aagttgtcca gaaatgaatc tgagctgatg gtgactttaa gttaatatta ttaatatatc      900

actgcatatt tttaccctta tttttgctcc ttacagcaag attagtaggt tataaaaatt      960

taaatttaaa caaaattatt tcatgacaaa atgggaaact tcacatcata cttatttttg     1020

tttgcctttc aggcatcata ttagctttta taaaaaatgg tcttgctgct gaaattgtac     1080

ttattttatc agaggctggg tgcagtcaag acaaaagtaa aatggtttac ctgagcccag     1140

gggagggaaa attgattaag atatcattat ttttgtttgg tttggttttg cttttttcct     1200

cttactttaa ttgaaatact ctgaattccc ctcatggaaa cagagagcat tgagagcact     1260

ttctttaaaa ggaccaaaaa taaattccta atagattttg tcct                      1304


<210> 2435
<211> 2416
<212> DNA
<213> Homo sapiens

<400> 2435
agagaagaag caggcagctt gagacaggtg gagctggatc aagctgtgaa cgtgatttgc       60

tggaagctgg tcattagtgt tgacgatgtg tcacactgtg taagggaatc gcatggagat      120

gggcattccg aactgttaat ggggacatgg gactccagtt gtctctgatc acttgtgtgg      180

attttcctgg cgtagaacga cagaagccgc tagtaagtcg ccaagaccta cagcaggaat      240

tctgcaccaa agggcataaa atcttgttat tttaatttgc atctgggaga atgtctgagc      300

aaggagacct gaatcaggca atagcagagg aaggagggac tgagcaggag acggccactc      360

cagagaacgg cattgttaaa tcagaaagtc tggatgaaga ggagaaactg gaactgcaga      420

ggcggctgga ggctcagaat caagaaagaa gaaaatccaa gtcaggagca ggaaaaggta      480

aactgactcg cagccttgct gtctgtgagg aatcttctgc cagaccagga ggtgaaagtc      540

ttcaggatca gactctctga aaactgcaaa tggaaaggaa ttcaaaagaa tttagattaa      600

aagttaaata aaaagtaggc acagtagtgc tgaattttcc tcaaaggctc tcttttgata      660

aggctgaacc aaatataatc ccaagtatcc tctctccttc cttgttggag atgtcttacc      720

tctcagctcc ccaaaatgca cttgcctata agaaacacaa ttgctggttc atatgaaact      780

taggaaatag tgaataaggt gcatttaact ttggagaaat acttttatgg ctttggtgga      840

gatttctcaa tactgcaaaa gttgtccaga aatgaatctg agctgatggt gactttaagt      900

taatattatt aatatatcac tgcatatttt tacccttatt tttgctcctt acagcaagat      960

tagtaggtta taaaaattta aatttaaaca aaattatttc atgacaaaat gggaaacttc     1020

acatcatact tatttttgtt tgcctttcag gcatcatatt agcttttata aaaaatggtc     1080

ttgctgctga aattgtactt attttatcag aggctgggtg cagtcaagac aaaagtaaaa     1140

tggtttacct gagcccaggg gagggaaaat tgattaagat atcattattt ttgtttggtt     1200

tggttttgct tttttcctct tactttaatt gaaatactct gaattcccct catggaaaca     1260

gagagcattg agagcacttt ctttaaaagg accaaaaata aattcctaat agattttgtc     1320

ctaagagagt gttttttttt ctagcatcat tttctttaca tgccactcat gtcataaggc     1380

atggacaggc tatctttcag tggccattac tatgtttcgt acacatgctt tattttactt     1440

gggctctgag aaatgtgtgg ctttccttca gcattttatt tgtgcttctc tttttaatgg     1500

agattgaaaa gggagaataa tgtgaatatc acggcttata ttattaaatg ttgattgatg     1560

gcttgtaatg tactgcacac aatatatgtt aactctgcag aatgacagac cctgggagaa     1620

gtaatgcccc agttgtcccc cactcctaat gccaggcaga gaaggacagc ctttatagac     1680

ttaatctgct ttttgtccca tttgacaagg taccaggagg aaatttttta agggatcaac     1740

tgtatcacag tgcccactct ggacctaagt ctagtgtatc catacaattg gtgcagagaa     1800

ataaggtgta aatggtgctt tgttcctgct ggttccaagc tcagaaacca agactagctt     1860

tgtaggagag aatgagagcc tgcaagcctc tctttggatt ggctgaggag tggtgggagc     1920

agggggttga tagaaaacat ccagacacac atataagcaa gtggccgtgc taccttttta     1980

gagaataaag aaacagactt ttgagtttat atgcaatgcc ttcattaggt accaccggca     2040

cttacaaaat gtgcggactg aatcccagag aacactggca gatgtataca gtatatggat     2100

tgtatcgctt ccccaatgtt tgtaaattca cagtatttgg aaaactgcct tcattttcca     2160

gtgtgggaaa aactcttgct acctgtatta cttgatctca gacccatacc tgatggttca     2220

gtctgtcctt aagttaaaag aattttgctt ttctaatgtt atactattta cctgtcagtg     2280

tattactgca acttgaatca ctcttttact gttgttggat ataaacttat cctgtaccaa     2340

tgtatttatt aacacttgta ttttattatt gagcatatca ataaaaatat taaaaaataa     2400

cagattgttt tttacc                                                     2416


<210> 2436
<211> 1994
<212> DNA
<213> Homo sapiens

<400> 2436
ggcttgctcg cgcgtgcgca ccagaagcca gcagtggggt tgcacacgcg cctcttcacg       60

aggtggaaac aagatggagg attcggcctc ggcctcgctg tcttctgcag ccgctactgg      120

aacctccacc tcgactccag cggccccgac agcacggaag cagctggata aagaacaggt      180

tagaaaggca gtggacgctc tcttgacgca ttgcaagtcc aggaaaaaca attatgggtt      240

gcttttgaat gagaatgaaa gtttattttt aatggtggta ttatggaaaa ttccaagtaa      300

agaactgagg gtcagattga ccttgcctca tagtattcga tcagattcag aagatatctg      360

tttatttacg aaggatgaac ccaattcaac tcctgaaaag acagaacagt tttatagaaa      420

gcttttaaac aagcatggaa ttaaaaccgt ttctcagatt atctccctcc aaactctaaa      480

gaaggaatat aaatcctatg aagccaagct ccgccttctg agcagttttg atttcttcct      540

tactgatgcc agaattaggc ggctcttacc ctcactcatt gggagacatt tctatcaaag      600

aaagaaagtt ccagtatctg taaaccttct gtccaagaat ttatcaagag agatcaatga      660

ctgtataggt ggaacagtct taaacatttc taaaagtggt tcttgcagtg ctatacgtat      720

tggtcacgtt ggaatgcaaa ttgagcacat cattgaaaac attgttgctg tcaccaaagg      780

actttcagaa aaattgccag agaagtggga gagcgtgaaa ctcctgtttg tgaaaactga      840

gaaatcggct gcacttccca tcttttcctc gtttgtcagc aattgggatg aagccaccaa      900

aagatctttg cttaataaga agaaaaaaga ggcaaggaga aaacgaagag aaagaaattt      960

tgaaaaacaa aaggagagga agaagaagag gcagcaggct aggaagactg catcagttct     1020

tagtaaagat gatgtggcac ctgaaagtgg tgatactaca gtgaagaaac ctgaatcaaa     1080

gaaggaacag accccagagc atgggaagaa aaaacgtggc agaggaaaag cccaagttaa     1140

agcaacaaat gaatccgaag acgaaatccc acagctggta ccaataggaa agaagactcc     1200

agctaatgaa aaagtagaga ttcaaaaaca tgccacagga aagaagtctc cagcaaagag     1260

tcctaatccc agcacacctc gtgggaagaa aagaaaggct ttgccagcat ctgagacccc     1320

aaaagctgca gagtctgaga ccccagggaa aagcccagag aagaagccaa aaatcaaaga     1380

agaggcagtg aaggaaaaaa gtccttcgct ggggaaaaaa gatgcgagac agactccaaa     1440

aaagccagag gccaagtttt tcaccactcc tagtaaatct gtgagaaaag cttcccacac     1500

ccccaaaaaa tggcccaaaa aacccaaagt accccagtcg acctaaagtc agtgattcaa     1560

ctggaaggaa acctcaatgc tgcctccaga gctttttgga aatactcaga tcctggccgc     1620

ctttgtaacc ttctctaaac gtcaggcctg gacttaaaag attttttaaa acctccataa     1680

gtagtccagg ggcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcaggc     1740

ggatcacaag gtcaacgaga tcgagaccat cctggccaac atggtgaaac cctgtctgta     1800

ccaaaaatac aaaaattaat tgggcatggt ggtggacacc tgtaatccca gctactaggg     1860

aggctgaggc aggagaattg cttgaacctg ggaggcggag gttgcagtga gccactgcac     1920

tccagcctga tgacagagca agactcagtc tcaaaaataa ataaaaataa taaaacctcc     1980

ataagtaatc ctga                                                       1994


<210> 2437
<211> 768
<212> DNA
<213> Homo sapiens

<400> 2437
ggtgtttggt ggagcccgcg atggccgaac ctgcgtctgt cgcggctgaa tctctcgcgg       60

gcagcagggc gcgcgctgca cgcacagtac taggtcaggt ggtgctcccg ggtgaggagc      120

tgctcctgcc ggaacaggag gacgcggaag gccctggggg tgcagtggag cgaccgttga      180

gcctgaatgc tagagcgtgc tcgcgggtgc gcgttgtatg cggtccgggc cttcggcgct      240

gtggggaccg cctgctggtc accaagtgcg gccgcctccg tcacaaggag cccggcagtg      300

gcagcggcgg cggtgtttac tgggtggact ctcagcagaa gcggtatgtt ccagtaaaag      360

gagaccatgt gattggcata gtgacagcta aatctggaga tatattcaaa gttgatgttg      420

gagggagtga gccagcttct ttgtcttact tgtcatttga aggtgcaact aaaagaaaca      480

gaccaaatgt gcaggctatt agctccagat tgtgaaatca tacaggaagt gggaaaactc      540

tatccactgg agatagtatt tggaatgaat ggaagaatat gggttaaggc aaaaaccatc      600

cagcagactt taattttggc aaacatttta gaagcttgtg aacacatgac gtcagatcaa      660

agaaaacaga tcttctccag attggcagaa agttgatata ggtggacttt tttacaggtc      720

agttgaggca aaaaactatg ggttttttca ggtgaacctc ccccattt                   768


<210> 2438
<211> 3012
<212> DNA
<213> Homo sapiens

<400> 2438
gactcctgtg cggaacgtga gtgactgagc ggcaaagccc gaatggtctc tagcgaccgg       60

cccgtgtcac tggaggacga ggtctcccat agtatgaagg agatgattgg aggctgttgc      120

gtttgctcag acgagagagg ctgggccgag aacccgctgg tttattgcga cgggcacggc      180

tgcagcgtcg cggtgcatca agcttgctat ggcattgttc aagtacccac tggaccgtgg      240

ttttgcagga aatgtgaatc tcaggagaga gcagccagag tgagatgtga actttgtccc      300

cataaggatg gagctttaaa aagaacagat aatgggggtt gggcccatgt ggtttgtgcc      360

ctgtatattc cagaggtaca atttgccaat gtttccacaa tggaaccaat tgttttacag      420

tctgttccgc atgatcgtta taataagact tgctacattt gtgatgaaca aggaagagaa      480

agcaaagcag ccactggtgc ttgcatgaca tgtaataaac atggatgtcg acaggctttc      540

catgtaacat gcgctcagtt tgccggactg ctttgtgaag aagaaggtaa tggtgccgat      600

aatgtccaat actgtggcta ctgtaaatac cattttagta agctgaaaaa gagcaaacgg      660

ggatctaata ggtcatatga tcaaagttta agtgattctt cctctcactc tcaggataaa      720

catcatgaga aagagaaaaa aaaatataaa gagaaggaca aacacaaaca gaaacacaag      780

aagcagccag aaccatcacc tgcattggtt ccatccttga ctgttactac agaaaaaact      840

tatacaagca ctagcaacaa ctctatatct ggatcattga agcgcttgga agatactact      900

gcacgattta caaatgcaaa tttccaggaa gtctctgcac acacctctag tggaaaagat      960

gtttcagaga ctagagggtc agagggcaaa gggaagaaat cttcagctca cagctcaggt     1020

caaaggggaa gaaagcctgg tggtggaaga aatccaggaa caactgtgtc agcagctagc     1080

ccttttcctc aaggcagttt ttcaggaact ccaggcagtg taaagtcatc ttctggaagt     1140

tcagtgcagt ctccccagga tttcctgagc tttacagact cagatctgcg taatgacagt     1200

tactctcact cccaacagtc atcagcaacc aaagatgtac ataaaggaga gtctggaagc     1260

caggaagggg gggtaaatag ttttagtacc ttaattggcc tcccttcaac ctcagctgtt     1320

acttcacagc ctaaaagctt tgaaaattca cctggagatt tgggtaattc cagccttcct     1380

acagcaggat ataagcgggc tcaaacttct ggcatagaag aagaaactgt aaaggaaaag     1440

aaaaggaaag gaaataaaca aagtaagcat gggcctggca gacccaaagg aaacaaaaat     1500

caagagaatg tttctcatct ctcagtttct tctgcttcac caacatcatc tgtagcatca     1560

gctgcaggaa gcataacaag ctctagtctg cagaaatctc ctacattgct caggaatgga     1620

agtttacaga gcctcagtgt tggctcatct ccagttggtt cagaaatttc catgcagtat     1680

cggcatgatg gagcttgccc aacaactagt atttataaca gcaatgatgt agcagtatcg     1740

tttccaaatg tagtatctgg ctcgggatct agtactcctg tctccagctc tcacttacct     1800

cagcagtctt ctgggcattt gcaacaagta ggagcgctct ctccctcagc tgtgtcatct     1860

gcagcccctg ctgttgctac aactcaggca aatactctat ctggatcttc tctcagtcag     1920

gcaccatctc atatgtatgg caatagatca aattcatcaa tggcagctct tatagctcag     1980

tctgaaaaca atcaaacaga tcaagatctt ggagacaata gccgcaacct agttggcaga     2040

ggaagctcac cccgaggaag tctctcgcca cgatcccctg taagcagctt acagattcgc     2100

tatgatcaac caggcaacag cagtttggaa aatctgcctc cagtagcagc cagcatagaa     2160

cagcttttgg agaggcagtg gagtgaagga cagcaatttt tactagaaca gggtactcct     2220

agtgacattt taggaatgct gaagtcatta caccaacttc aagttgaaaa ccgaagatta     2280

gaggaacaaa ttaaaaactt gactgccaaa aaggaacggc ttcagttatt gaatgcacag     2340

ctttcagtgc cttttccaac aataacagca aatcctagtc cgtctcatca aatacacaca     2400

ttttcagcac agactgctcc tactactgat tccttgaaca gcagtaagag ccctcatata     2460

ggaaacagct ttttacctga taattctctt cctgtattaa atcaggactt aacctccagt     2520

ggacaaagta ccagcagctc atcagctctt tctaccccac ctcctgctgg gcagagtccg     2580

gctcaacaag gctcaggagt gagtggagtt cagcaggtca atggcgtgac agtgggggca     2640

ctagctagtg gaatgcagcc tgtaacttcc accattcctg ccgtgtctgc agtgggtgga     2700

ataattggag ctttgccagg taaccaactg gcaattaatg gcattgtagg agctttaaat     2760

ggggttatgc agactcctgt cacaatgtcc cagaacccta cccctctcac ccacacaacc     2820

gtaccaccta atgcaacaca tccaatgcca gctacactga ctaacagtgc ctcaggacta     2880

ggattacttt ctgaccagca acgacaaata cttattcatc aacagcagtt tcagcagttg     2940

ttaaattctc aacagctcac accaaacatg gttaaggaat tttcagcaca aattattgct     3000

tggagaccat ga                                                         3012


<210> 2439
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 2439
gggagattac ggggcgggga cgagctgtcg cgctggttgc tcgtgcagga gcgggacccg       60

gaacagaccg ccgtgagaga ggaggggtgc cggccgggat tcgcggcccg gagctcggga      120

ccggttgctt cattccagcc tcgcagtcac ctctgtgccc tgctggttgt cttcccagcg      180

ctgctgtagt tgccttccat ggatctatag gagagcaagt cctccaggag aagaagtcct      240

caccagtgaa cggagacctc tctgaactaa ggataccatg gccacgtcag ccccactacg      300

gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac      360

cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg      420

gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt      480

gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca      540

gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa      600

gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg      660

ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa      720

aatcctgaac cacctgagta ccctaaggag ggacagagac aaaattcagg gcttccaggc      780

aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat      840

tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga      900

acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg      960

cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca     1020

gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa     1080

gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga     1140

taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt     1200

ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct     1260

gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc     1320

ccagcagttt gactgtgagc ctggggtgct aggcagcaag ggcttcacct ggggcaaggt     1380

ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga     1440

ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga     1500

cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga     1560

ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag     1620

gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc     1680

cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag     1740

agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca     1800

ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct     1860

caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc     1920

caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc     1980

ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct ccccattgct     2040

gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt     2100

ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct     2160

ttcctttttg accacgacct tggccccagc tctgcactct ctggaataag ggcccgatgc     2220

agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc     2280

attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc     2340

ttccctggca ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa     2400

tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag     2460

cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc     2520

atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat     2580

ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga     2640

ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc     2700

aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc     2760

gggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact     2820

ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc     2880

ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa     2940

cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa     3000

ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa     3060

gttttaagtc ctccaccctg ttctaagaga ctgttccaac ggctctgggc ctcagtggtc     3120

acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca     3180

catgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta     3240

tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat     3300

aaagacttgt tgaatgaa                                                   3318


<210> 2440
<211> 3026
<212> DNA
<213> Homo sapiens

<400> 2440
ggtgccttag gcgctggaga aaaacttcac ccgcgcccac aggccccctt tccgcaggct       60

gcgctggcgg ttcaggtttg caggccggaa gtgaaatgtt cttttttgat ttttaaaaag      120

gaagcctccg gccctatggt tttctggggt tggagtggat gtgtgtgctg ggggaggcgg      180

agacgtcccg ctccaggcag ggccttgggt cttaataggt ggggaaatct ctgccaaata      240

ggaggcctct cggagcctca gtttccccat ctgcagactg ggctctgact tcttctggca      300

tgagagggtg tgtgagagta aaaggaggca gctagccccg tgccgggaga cacgtcagcc      360

atgtcatctg agcctccccc accaccacag ccccccaccc atcaagcttc agtcgggctg      420

ctggacaccc ctcggagccg tgagcgctca ccatcccctc tgcggggcaa cgtggtccca      480

agcccactgc ccactcgccg gacgaggacc ttctcggcga cggtgcgggc ttcacagggc      540

cccgtctaca aaggagtctg caaatgcttc tgccggtcca agggccatgg cttcattact      600

ccagctgatg gcggccccga catcttcctg cacatctctg atgtggaagg ggagtatgtc      660

ccagtggaag gcgacgaggt cacctataaa atgtgctcca tcccacccaa gaatgagaag      720

ctgcaggccg tggaggtcgt catcactcac ctggcaccag gcaccaagca tgagacctgg      780

tctggacatg tcatcagctc ctaggagatg gtggaagcac cccttgtcct gtgcttgtgg      840

gagactttgc agggaggagg cagcagacac tggagatgac attcttccac acgagacggg      900

gcttcagccg ggcatggtcc ctctcaagta tctcctggag gaaggggtat ggggggcagg      960

tgtggggtgt ggggtgttcc cggccatcag cacagcctat gaccattgca acaacctctc     1020

accatctgaa gagcattaaa agcatttaaa aaggagaggt gcccactggt ggctgagtgg     1080

aggttccaac cccatcccag ggagtggatc aagggtggta tttctccagc tgctcagaca     1140

catgggctca acccacagaa tccctcttcc tcctggagct ggaggcccca gattcccaga     1200

tctggccccc tggcagcctg acagggacct tgcgtgactt ctccaaggca aatttccacc     1260

taagtgcccc ttgcgcctct cctggggcct gggcaaagca gttttctaat tcttggcttg     1320

gttggttcta ggggagctgg cttgaagtgg gtggggaaag gcgggggtgg cggtctttgg     1380

attggacgga tgttgccttt tggtgccttt gcagtgggag gcggcatagc tgcctgtctg     1440

gggaagacag ttctcccagc actcccaccc ctgggcacag caggctggta ctgggaggct     1500

gaacccctct tagagcctga ccttttcatc tgccttctgg ttgtgtgacc atcactcaac     1560

agccatttca cagcccctgt aattatggcg gcggggggct ggggtggtgg tggtgggaag     1620

ggcttgtgga gaggacacag tctttgttta aaaactttgt cccgatccat ccagaaaaga     1680

gtaggtagct tgcatcctga cagcctggca aagtcaagaa agttgaagga gaaacatacc     1740

tttggagagg gggttttctt taaaactagt gttaagaaat gcttagggat tttttttttc     1800

ttatttttca taactaaagc tttcacccag agccggctct gtttgcactt tgctgccgac     1860

attgcaaact ttttggcagg gtgggagact gagtctcatt ctgtcaccca ggctggagtg     1920

cagtggcccg atctcagctt actgcaacct ctgccctcca gggttctggc aattccgcct     1980

cagtctcctg agtagctggg attacaggca tgcgccacca cacccggtta atttttgtat     2040

ttttagtaga gaccaggttt catcatgttg ggcaggatgg tcttgaaccc ctgacctcag     2100

atgatctgcc catctcggcc tctcaaagtg ctgggattac aagtgtgagc catcgcgccc     2160

ggcctgcaaa cttttttgta ggtatttctg gtaaacaaat ccttaggtta tctttgctgt     2220

ggttgtggtt tggctttagt catgatttca aagtagaaat agctaggcat tattttttga     2280

aatatatgac ctatatgtag tcaagaatcc actgaacaga ggcaagcaaa ccttttggaa     2340

actggctttt gggcagacag taaacgtcca gtttgatgct ggaagcatga acagcttcat     2400

caggtaggta ctcctcaact ctgatgagtt tgtcctttca gcctaagggg gtggaaggga     2460

gttgtttgag aatagcaaat acgcatgttg attgcgagtg tgtggagaca aaggcagttc     2520

ccaccacagt taggtcctgg ccattgtttc ctcgcctgcg atgctccttg tacatcctca     2580

ccctcctctc ccgcctctgc cttctgctgg gtcaaaggtg gccttttctc tccagccttg     2640

aattgttccc tgttggcttc ccaagggccc atctgctggt acagtccaca cttccacagc     2700

caagacccga gagggctttc actgccccaa gcctctctcc tgtgaccctg ggattctgtc     2760

ttggcagaat cctttgtcag cggctcttac tctgtccttc ctgtttggcc acagctcttt     2820

caatcaatgg gtattctaga accgcaggat gtcagagctg gaagggacgc gataccggtt     2880

tacacaaggg gaaactcctc gaggctctgg gagggacgga gggttttggt gacagagcga     2940

gagctaaaat tgaggattcc tgaatccaga tcttgcctcc catcagccat ctttctccca     3000

ataaattttt gttttgtgca aggcta                                          3026


<210> 2441
<211> 1380
<212> DNA
<213> Homo sapiens

<400> 2441
ggccctcgcg gggggcttgt gggtcctcct ccccctccca ctgacaactg ccccaactgc       60

tcttcccgcc ccggtcacag tgaaaatgta gacggggtcg ttgtccacta tgttaggtct      120

taatggtggg aggacgcccg agtgctcggc ccgtttcacc ccgaggagga aggacactgg      180

gtcatgacgc catcagaggg cgccagagca gggaccggac gcgagttgga gatgttggac      240

tcgctgttgg ccttgggcgg cctggtgctg cttcgggatt ccgtggagtg ggaggggcgc      300

agtctcttga aggcgcttgt caagaaatct gcactgtgtg gggagcaagt gcatatcctg      360

ggctgtgaag tgagcgagga agagtttcgt gaaggttttg actctgatat caacaatcgg      420

ctggtttacc atgacttctt cagagaccct ctcaactggt caaaaactga ggaggccttt      480

cctggggggc cgctgggagc cttgagagcc atgtgcaaga ggacagatcc tgttcctgtc      540

accattgctc tcgattcact cagctggctg ctacttcgcc ttccctgcac cacactctgc      600

caggtcctgc atgctgtgag ccatcaggac tcttgtcctg gtgacagctc ctcagtgggg      660

aaagtgagtg tgctgggctt gctacatgaa gagcttcatg gaccaggccc tgtgggagct      720

ctcagcagcc ttgctcagac tgaggtgacc ctgggcggta ccatgggcca ggcctcggcc      780

cacatcctgt gtcggaggcc ccgacagcgc ccaactgacc agactcagtg gttctccatc      840

cttccggact tcagcctgga tctccaagag gggccctctg tagagtccca gccctactcc      900

gatcctcata tacccccggt ggatcccaca actcatttga cctttaacct tcacctgtcc      960

aagaaagaga gagaagccag agatagcctg atcctgccct tccagttcag ttctgaaaaa     1020

cagcaggctc tcctgcggcc taggccaggg caggctacca gccacatctt ctatgagcca     1080

gatgcttatg atgacctgga ccaagaagac ccagatgacg acctggatat ttgactggcc     1140

agatttgatt agattgtaat tggagggggc gcgggaagac tttgggccca gaaccatctt     1200

tctattgttt gtgttagcct taccctgtcc ctgccccacc ttggttcccc ttgtctatgg     1260

agccccgcct tgtgagccag gaagcagcgt ctcatcagga cagaaggtag gatgaagaca     1320

tggggtaatg tgagagagta gaacaccccc gtacctaata aaaatcttta tttttttatt     1380


<210> 2442
<211> 1468
<212> DNA
<213> Homo sapiens

<400> 2442
ggccctcgcg gggggcttgt gggtcctcct ccccctccca ctgacaactg ccccaactgc       60

tcttcccgcc ccggtcacag tgaaaatgta gacggggtcg ttgtccgtac gactgtgcgc      120

cagggctcgg ggaggggcgc cctccgcgtg agcgcccccc tgggaatatt gaacataatc      180

acctctcatt ccagactatg ttaggtctta atggtgggag gacgcccgag tgctcggccc      240

gtttcacccc gaggaggaag gacactgggt catgacgcca tcagagggcg ccagagcagg      300

gaccggacgc gagttggaga tgttggactc gctgttggcc ttgggcggcc tggtgctgct      360

tcgggattcc gtggagtggg aggggcgcag tctcttgaag gcgcttgtca agaaatctgc      420

actgtgtggg gagcaagtgc atatcctggg ctgtgaagtg agcgaggaag agtttcgtga      480

aggttttgac tctgatatca acaatcggct ggtttaccat gacttcttca gagaccctct      540

caactggtca aaaactgagg aggcctttcc tggggggccg ctgggagcct tgagagccat      600

gtgcaagagg acagatcctg ttcctgtcac cattgctctc gattcactca gctggctgct      660

acttcgcctt ccctgcacca cactctgcca ggtcctgcat gctgtgagcc atcaggactc      720

ttgtcctggt gacagctcct cagtggggaa agtgagtgtg ctgggcttgc tacatgaaga      780

gcttcatgga ccaggccctg tgggagctct cagcagcctt gctcagactg aggtgaccct      840

gggcggtacc atgggccagg cctcggccca catcctgtgt cggaggcccc gacagcgccc      900

aactgaccag actcagtggt tctccatcct tccggacttc agcctggatc tccaagaggg      960

gccctctgta gagtcccagc cctactccga tcctcatata cccccggtgg atcccacaac     1020

tcatttgacc tttaaccttc acctgtccaa gaaagagaga gaagccagag atagcctgat     1080

cctgcccttc cagttcagtt ctgaaaaaca gcaggctctc ctgcggccta ggccagggca     1140

ggctaccagc cacatcttct atgagccaga tgcttatgat gacctggacc aagaagaccc     1200

agatgacgac ctggatattt gactggccag atttgattag attgtaattg gagggggcgc     1260

gggaagactt tgggcccaga accatctttc tattgtttgt gttagcctta ccctgtccct     1320

gccccacctt ggttcccctt gtctatggag ccccgccttg tgagccagga agcagcgtct     1380

catcaggaca gaaggtagga tgaagacatg gggtaatgtg agagagtaga acacccccgt     1440

acctaataaa aatctttatt tttttatt                                        1468


<210> 2443
<211> 1734
<212> DNA
<213> Homo sapiens

<400> 2443
cgcgcagaag tccggggctg gcaagcgctt cctgcgcagc gcctaggcga cctggagttt       60

gtgacgctgt gatggtctag aggctggaga ttcaagatct gggtgccatc attttctggt      120

tctgttgatg accctcttcc aggttacata cagcttacat cttgcatcct caagcgtttt      180

tcttataagg ctaaaaattc acaaagcata tatcaatgaa tcaggaggat ctagatccgg      240

atagtactac agatgtggga gatgttacaa atactgaaga agaacttatt agagaatgtg      300

aagaaatgtg gaaagatatg gaagaatgtc agaataaatt atcacttatt ggaactgaaa      360

cactcaccga ttcaaatgct cagctatcat tgttaattat gcaagtaaaa tgtttaaccg      420

ctgaactcag tcaatggcag aaaaaaacac ctgaaacaat tcccttgact gaagacgttc      480

tcataacatt aggaaaagaa gagttccaaa agctgagaca agatcttgaa atggtactgt      540

ccactaagga gtcaaagaat gaaaagttaa aggaagactt agaaagggaa caacggtggt      600

tggatgaaca gcaacagata atggaatctc ttaatgtact acacagtgaa ttgaaaaata      660

aggttgaaac attttctgaa tcaagaatct ttaatgaact gaaaactaaa atgcttaata      720

taaaagaata taaggagaaa ctcttgagta ccttgggcga gtttctagaa gaccattttc      780

ctctgcctga tagaagtgtt aaaaagaaaa agaaaaacat tcaagaatca tctgtaaacc      840

tgataacact gcatgaaatg ttagagattc ttataaatag attatttgat gttccacatg      900

atccatatgt caaaattagt gattcctttt ggccacctta tgttgagctg ctgctgcgta      960

atggaattgc cttgagacat ccagaagatc caacccgaat aagattagaa gctttccatc     1020

agtaaaagga tgttttcttt tttcacacag taaaaattct tatcattcaa ggatattgga     1080

accacaggac tatttggata aaaaacatta tttgcaaatt aatgcgcata ggccatctta     1140

cttttattgc aaaatggcat gtgctgccat ctattattca tttttaaatg gtcatttctt     1200

attcagtgag tgctttagtg ttttaaacta tatggataag aatgcaggta gataatattc     1260

taggcataaa acatttaatg taccttacct catgcaatat tctttggatt ctttgttgat     1320

ttatgatatt gctaatataa tattttctta aaatatataa caatatcttt tatgcatttt     1380

gagttccagc tggtgcttct ttatatttag aaattataat gggaaggtca tttaatttac     1440

agatggtttt aaaattgagg taatatctga ggtggcataa tttaaaaata tttagcaaat     1500

ttgtttcata tatactgtct tatttctaga tttgtttaaa attggaatat gaaaaactaa     1560

tggataaagc tagcataaaa ttgatatttt agtttgtatt attaatatat catgttacct     1620

tatatattaa tctactcttg attctgctaa ttattaccaa caaaattgta ttcatgacat     1680

tttattaatc ctctgtgaat tttctgtaaa taaaattatt tctgaaaatc tcta           1734


<210> 2444
<211> 3824
<212> DNA
<213> Homo sapiens

<400> 2444
gagcacagag aagctcccag ctttgaaggt cttgcggtgg tgcgtggcgg gcaggaaccc       60

acaattccaa atacaaacgg tcggcgcgag aagcgcttct gggcgcaggc gcctggctgt      120

agcgactggt tgcgggaggc tggactctgg tgactgtaag catcaagtgt acctgatttg      180

tgaacctatc ttgcttcagt tggtttcctc ctaaatatta ggcagatggg attggctggt      240

ctgtgctctg ctaggtgaaa aattagacga tttcaagaat tggagctgaa tctgatgtta      300

agtaatggca acaggtgact taaaaagaag cttacggaac ctagaacagg tgctccgctt      360

gctaaattat cctgaagagg tggactgtgt aggtttgata aagggagacc cagcagcatc      420

tttgcccatc atcagctatt cttttacctc atactcacct tatgtaacag aacttataat      480

ggaatccaat gtagagctca tagcaaaaaa tgacttgcgc tttatagatg ctgtctataa      540

gcttcttcgt gatcaattta attataaacc aattttgaca aaaaagcagt ttatccaatg      600

tgggtttgca gaatggaaaa tccaaattgt ttgtgatatt ttgaattgtg tgatgaaaaa      660

gcacaaggaa ttaagcagtc ttcagaagat tccatcacaa caaagaaaga aaatcagttc      720

tggtaagtca gaacctcctt tgggcaatga gaaaatatct gcagaggctg ttggcgttga      780

tatcagtggc aggtttatga cctcaggaaa gaagaaagct gtggtgattc gtcacttgta      840

taatgaagat aatgttgaca tttctgagga tacattaagt ccaataacag atgttaatga      900

agcagttgat gtgtctgact taaatgctac tgaaataaag atgcctgaag taaaggttcc      960

tgaaatcaag gctgagcaac aggatgtaaa tgttaatcct gagattactg cactacaaac     1020

tatgcttgct gaatgccaag aaaatcttaa gaaactgact tcgatagaga aaaggttaga     1080

ctgtttggaa caaaaaatga aaggaaaagt gatggtagat gaaaacacct ggactaatct     1140

tcttagtcgt gtcactcttc ttgaaacaga aatgcttttg tctaaaaaga atgatgaatt     1200

tatagagttt aatgaagtta gtgaagacta cgcttcttgt agtgacatgg accttctgaa     1260

tcctcacaga aaaagcgaag tagagaggcc agcaagtatt cctctgtcct ctggctatag     1320

tacagcatca tcagattcaa ctcccagagc ctctactgtt aattactgtg gtttgaatga     1380

gatttcagag gaaacaacaa tccagaaaat ggaaaggatg aaaaaaatgt ttgaagaaac     1440

tgcagagtta ctgaaatgtc caaatcacta cttgtaggat tttctacatg aacttttttc     1500

taggactttg gttactatac atattgtata ttttaagaat tctttataca attttaatat     1560

actgcaatac tgcagttttt gacaatttgg attccatttg gtatatgaat ttttgcattc     1620

attattgaat aactctttta atatttttga gcaatgatta tactgcttta ccttgtgtca     1680

cttttttttt ttttaggaaa aactcatgtt ccagtatatt tctcttacag agtgaagtca     1740

ttacagcact gtatttctgt gttgacattt gttggcagtg tgctaagtaa tgttttttaa     1800

agcacaggct tgaggactat ggtttacatc ctgttggaaa cattccaaat gggacttgtg     1860

tattataccc aggaggctct catatatacc atcttggcat ctgtactgat gaataagtta     1920

taatgaacag ttaaaaatgc tcattgaaaa ttaaataaaa caaaaaggca gttatttcat     1980

gcttggtcaa aaacatcaat acctttccaa ttaacactga gaaattaagg ttaagattct     2040

ccttttgtac tgggaaacag gctggaggac tatggtcctc aagtttagac caagaggact     2100

atggtctcaa ggttcaccat gagaaatgtg ttgaacattt tagtatgctc tattgtataa     2160

tttttttgga gggggggatg gagtttcgct gttgttgccc aggctggagt gcaatagcac     2220

gatcttggct caccgcaacc tctgcctacc gggttcaagt gattcttgtg cctcagcctc     2280

ctgagtagct gggattatag gcatgcacca ccatgcccag ctaattttgt atttttatta     2340

gagacagggt ttctccgtgt tggtcaggct ggtctcaaac tcctgacctc aggtgatctg     2400

cctgtcttgg cctccggcgt aacacttttt aagaccagtg taacagaaag agaatgtagc     2460

cattctagcc accgttaaaa gatacacagt gaggtgttgt gttttgtttt tttaatgatg     2520

aaaagttaca cattttttgg agagaaaagt cttagctgaa ggtaaatcaa tggaaaaatg     2580

aaatttattt ttaatattac tactatatga attatctttt tttaaacttg tagataaaag     2640

tgttccagta atcagaaaat cctcaagaaa attgacttca ttatttggaa ggaaaattag     2700

tatttttttt aatattatat ggaccatctg attatatttt atttattcat ctatttatgg     2760

gtctcactct attgcccagg ctggagtgca ctggcgtgat ctcggctcac tgcaccttct     2820

gcctaccgag ttcaagcgat tcttgtgctt cagcctcctg agtagctggg actataggcc     2880

tgtaccgtca tgcctggcta atttttgtat ttttgtagag acagggtttc accatgttgc     2940

ccagtctgtt ctcaaactcg tgagctaaag ctactcgccc acctggatgt cccaaagtgc     3000

tagattccat ggaattttcc tgcatggagt gctacatcct cttgttccag tctcagctgg     3060

ctgctccgtg ggcatacttc atacctttca tcacagagct ttgcttggcc tctctcctgt     3120

gtgtaatctc tgtttcttgg atcctgtgct taccttttcc tgctgtactc tgatgtttca     3180

gtgaagctca tccacgaagt ccagaattct gcctggaaac cagcttcctc ctcagctcca     3240

gctcttttaa tgggcatatc aaaactgatg actttttcct tcctgctaca tgggtaacac     3300

ttagttgttt gtctaatttc tattttccag aaatttctca aaatgtctgc tgatagcccc     3360

tcactcatat ttttcatgtg ggtttatagc tttcatattt ctttattatt gtaaatgggg     3420

gctgtggaag gtgagaaaac acatgctttc ttaaaacaga agctctctcc ttcattaatt     3480

taaatatttt tatcggctct agaaaatgca taaggttagt acaagatcag tagagagaaa     3540

gtcaaagatt acagaagtgc tgaagcagac cattcttcct ttcttcccaa tgtctattaa     3600

gatcacacat aggtaaactg ttacaaatcc agaatggtga aagagtccaa caatggctga     3660

gggaagtaga ggttaagata tagctcaaca gtgaaagtag cagggaaaga gctgggcaag     3720

gccaagacca tcttttgtac cgttggtaca gtaggctaaa ggtacggtgt tccatattaa     3780

atacagcaat atgaagaaaa ataaattaag tcccttatac ctaa                      3824


<210> 2445
<211> 1269
<212> DNA
<213> Homo sapiens

<400> 2445
gcaggcggca ggaggcgggt gggtcaaggt aactctgggc tacagagtcc ttgctggggg       60

ttcggggagc gcttggaccc cggcttctgg gacgcgtcag aatattatcc agcaatgcaa      120

atgaacaaac tataactaca cacagctgca tggataaatg tcagaaacat gacgttgagt      180

gtgagaagcc agatgcaaac gaggactcac tgtgcaattc tgtgcatgta cagtggccag      240

gagaagggag cactggcttt gctttcatca ggccaaagat gcctttcttt gggaatacgt      300

tcagtccgaa gaagacacct cctcggaagt cggcatctct ctccaacctg cattctttgg      360

atcgatcaac ccgggaggtg gagctgggct tggaatacgg atccccgact atgaacctgg      420

cagggcaaag cctgaagttt gaaaatggcc agtggatagc agagacaggg gttagtggcg      480

gtgtggaccg gagggaggtt cagcgccttc gcaggcggaa ccagcagttg gaggaagaga      540

acaatctctt gcggctgaaa gtggacatct tattagacat gctttcagag tccactgctg      600

aatcccactt aatggagaag gaactggatg aactgaggat cagccggaag agaaaatgaa      660

gaccccagag acatttattg gggagtagga tgtggctgag tgcttttttt ttggccagac      720

tagcggattc agtcctggaa gagagtatca tataatgaga cccacaggca ctggcaccct      780

tgggttggca atagaaggtg acatggaatg gagaaaacca agattccaga tggggatagt      840

aactagaagg tgcttcagat gcactgcctg cgggtgccag tctgaaaacc agaccgcaca      900

gaggcctggg gctgctgatg agctttttgg tgctctccac acacaagctc gcaaacacac      960

atgtcccaga atagctctgt tgggttgtgt tgggagaagc ggctggagtt cattctctca     1020

cccccttatg ttggtgtttg gcgtgtgaca gcagttctac agagctctgt gttggggtca     1080

tggatgagcg gctctcttgg ctcttaaagg caggcctctc tcttcttgcc tttaaagaat     1140

cctccttcct cacacctggc ctcctctggc ttcagcttct cagcagcaag caccagcctt     1200

ccacaacaac actatatttt tatgctactt tcctgtttgc actactactt ttttattaaa     1260

cgatgttaa                                                             1269


<210> 2446
<211> 1552
<212> DNA
<213> Homo sapiens

<400> 2446
gctcaggccc cgccctcaga cgagcaccgc ccgccggctc ctcccgcggc tcgaatcgcc       60

gtctctctcc tccccgcccc gccgagttct agaattcgcc gcgcagctgc ttcagcccct      120

cagccccagc cggaccctcg ggtcctcatc caccctcgca ggcgcaggcc gtggctaccc      180

cgaagtcaac tgtggaggat ccttcctggc ttccttcagc tccatcctgc ccttggatct      240

aggtcacccg cttggaccca actatctgag gcccgaatgc cccgcagctc ccgctgctcc      300

ctcgcgttct gctgaccccc ctccgagtca ggacatcccc tttagacccc actttaggcc      360

ctttcagccc aactccaact agccccatct gccgcttccg cacgagacag agtttcactc      420

ttgttgcaca gactggagtg caatggcgcg atctcaactc accgcaacct ctgcctccct      480

ggttcaagca attctcctgc ctcagcctcc tgagtagctg ggattacagc accaaaaagg      540

agactaacta cccagccccg tccagtcatg caggtgcagg atgatggagt caacctcatc      600

ccctttgcca agtgttccag ggtggtcagc cgatctccac ccccaaggtt gccttcccag      660

agcctcagac ccatgcccca gcgttatgga gatgtcttct ggaagaacct taatcaaagg      720

cccaccccca cttggctgga ggagcagcac attccaccca tgctgagagc cactggttgc      780

tcccagcttg gtctgtatcc tcctgagcag ctcccacccc ctgaaatgct ttggagaaga      840

aagaagagga ggccatgttt ggaaggaatg cagcagcagg gccttggggg agtccccgcc      900

cgggtgaggg ctgtcactta ccacctggag gacctaagaa ggcgtcagag catcatcaac      960

gaactgaaga aggcccagtg gggcagctct ggggctgcat ctgagccagt ggtgcttggc     1020

gaagagggct gtggattccc cagcaccaat gaataccctg atctggaaga ggagagagca     1080

acctatccac aggaagagga ccgttttctc actcctggca gggcccagct gctttggtct     1140

ccctggagcc ccctggatca ggaggaggct tgtgcctcca ggcagctgca ctctctggcc     1200

tcgttcagca ctgtcacagc cagaaggaac ccccttcaca atccctgggg gatggagttg     1260

gcagcgtctg aagagtaagg agaaaccacc gatgccgaga ggctagtggt gccccaggga     1320

cccaagacta gttccgtcac tagagtcacc ctcattgctg acatgaaggc gtttcccctt     1380

ccttcgtctc tccaactgcc tttcccatcc tctgaactag gcattaacag cccccgtggg     1440

ctcccatctc aacccaccgc tctcacagga gcaccccaag tcctgttttc ctccaggccc     1500

cgctcctggc cttgtattct ctctgctctg ttattaaaaa gcaagcaagt gg             1552


<210> 2447
<211> 2677
<212> DNA
<213> Homo sapiens

<400> 2447
tgctcctgca ccggtctgca tctcccagca gaaggcgcag ccatgaatcc gttattcggc       60

cccaacctct tcctcctgca gcaggagcag cagggcctgg ccgggccact gggggactca      120

ctgggaggcg accacttcgc cgggggagga gacttgcccc cggcgcctct ctcgccggcc      180

ggccctgctg cctactcgcc gcccgggccg ggcccggccc cgcctgccgc catggccctc      240

cgcaatgacc tgggctccaa catcaacgtg ctcaagaccc tgaacctccg gttccgctgc      300

ttcctggcca aggtgcatga gctggagcgc cggaaccggc tgttggagaa gcaactgcag      360

caagcgctgg aggagggtaa gcagggccgg cggggcctgg gtcgtcgcga ccaggcagtg      420

cagaccggct tcgtcagccc catccggccc ctggggctgc agctgggcgc ccggccggcc      480

gctgtctgca gcccttcggc gcgcgtgctg ggctcgcccg cgcgctcccc ggccggcccc      540

ctcgcgccct ccgcggccag cctctcgtcg tcctccacct ccacctccac cacctattcc      600

tcgtcggccc gcttcatgcc cggcaccatc tggtcgttct cgcacgcccg ccggctcggg      660

ccgggactgg agcccactct ggtgcaaggg cctggcttgt cgtgggtgca cccggatggg      720

gtgggcgtcc agatcgacac catcacgccc gagatccgcg ctctctacaa cgtgctggcc      780

aaagtgaagc gggagcggga cgagtacaag cggaggtggg aagaggagta cacggtgcgg      840

atccagctgc aagaccgtgt aaatgagctc caggaggaag cccaggaggc tgatgcctgc      900

caggaggagc tggcactgaa ggtggaacag ttgaaggctg agctggtggt cttcaagggg      960

ctcatgagta acaacctgtc ggagctggac accaagatcc aggagaaagc catgaaggtg     1020

gatatggaca tctgccgccg catcgacatc accgccaagc tctgcgatgt ggctcagcag     1080

cgcaactgcg aggacatgat ccagatgttc caggtcccat ccatgggggg gcggaagcgg     1140

gagcgcaagg ctgccgtcga ggaggacacc tccctgtcgg agagtgaggg gccccgccag     1200

cccgatgggg atgaggagga gagcacagcc ctcagcatca acgaggagat gcagcgcatg     1260

ctcaaccagc tgagggagta tgattttgag gacgactgtg acagcctgac ttgggaggag     1320

actgaggaga ccctgctgct ttgggaggat ttctcaggct atgccatggc agctgcagag     1380

gcccagggag agcaggaaga tagcctggag aaggtgatta aagatacgga gtccctgttc     1440

aaaacccggg agaaggagta tcaggagacc attgaccaga tagagctgga gttggccacg     1500

gccaagaacg acatgaaccg gcacctgcac gagtacatgg agatgtgcag catgaagcgc     1560

ggcctggacg tgcagatgga gacctgccgc cggctcatca cccagtctgg agaccgaaag     1620

tctcctgctt tcactgcggt cccgcttagc gacccgccgc cgccgccaag cgaggctgag     1680

gactccgatc gcgatgtctc atctgacagc tccatgagat agagacctgc ctcccccttg     1740

cacccgaggc cctcgcagca gggagctcag cgaggcagag ggtggggctg cacagagggg     1800

aacatcagct gcagctctgc accaggccgg tccctgggga ctggggcgct cctccctcag     1860

gctttctccc tcagtcttgg cttctccagg gctctggggt gtctggagct aggcttggcc     1920

ctaccattct ggggccattt ccaccacagt tggggctctc ctgccttcac gcgtgggtgt     1980

ctgctacttc cccatcttta aaatgctgcc agagcgattg cggcccctca ccttgtccac     2040

gtatcaggaa tgtgaatgtg ggacctttcc tccatccctg ttgtccggag ccagctcact     2100

gtcttccaca ctggtgctaa ctggcccagg cactggagtg gaatagaatg cagctggagg     2160

ctacgcatgg cctctgcagc acacgcagct ggagagggct tctgtccctg tcagcggcag     2220

agggcgttgg ggctggccgg ggcaccttgt ccctgctatg gtccacgtgc tcacgctgtc     2280

cacctgccag gtggagtgta tgtggctgtg gccctccctc gtggaggtgc cgtgctttaa     2340

agaggcctta gtgcccggga tgggcacagt gttttgaagg gaggtgggag ctcttgctct     2400

cctggtcact gcagaatgac agagaaggtg aagctccatg catgtgtgcg cgggtgtatg     2460

tgcgctcagg gtctctgttt aagtatcagc taaagatgtg cttcctccgt gtctgtcata     2520

cactgagacc aacaggctac agtgtccctg attcttggaa aagcctggag aagctgggga     2580

gatgcggttc acaatgcctc ggtataggag gctgtgttga gctgacattc aaatggattc     2640

tttaataata atgaaactgg cgagtattta ttgtgca                              2677


<210> 2448
<211> 1838
<212> DNA
<213> Homo sapiens

<400> 2448
atctgaggga ggcaggggaa tgagccaggc tggagctgag ccagcagggc agggcccccc       60

tgctgcgaca gtggcatcct gatagtgaga tgctcagatg ctgctgccct ctagtggccg      120

ccagttccct gcaactcaga ccacgtgatt tctgggaaaa ggccctccct ggaggagaac      180

tgaaacttag ggtggggact gtagaaaggg gcggagagat cagccgccca gccaggagtt      240

aagctgaggt cgtctgagcc ctgcgacagc ctggacagca actcaggatg gcatcaggca      300

gggcacgctg cacccgaaaa ctccggaact gggtggtgga gcaagtggag agtgggcagt      360

ttcccggagt gtgctgggat gatacagcta agaccatgtt ccggattccc tggaaacatg      420

caggcaagca ggacttccgg gaggaccagg atgctgcctt cttcaaggcc tgggcaatat      480

ttaagggaaa gtataaggag ggggacacag gaggtccagc tgtctggaag actcgcctgc      540

gctgtgcact caacaagagt tctgaattta aggaggttcc tgagaggggc cgcatggatg      600

ttgctgagcc ctacaaggtg tatcagttgc tgccaccagg aatcgtctct ggccagccag      660

ggactcagaa agtaccatca aagcgacagc acagttctgt gtcctctgag aggaaggagg      720

aagaggatgc catgcagaac tgcacactca gtccctctgt gctccaggac tccctcaata      780

atgaggagga gggggccagt gggggagcag tccattcaga cattgggagc agcagcagca      840

gcagcagccc tgagccacag gaagttacag acacaactga ggcccccttt caaggggatc      900

agaggtccct ggagtttctg cttcctccag agccagacta ctcactgctg ctcaccttca      960

tctacaacgg gcgcgtggtg ggcgaggccc aggtgcaaag cctggattgc cgccttgtgg     1020

ctgagccctc aggctctgag agcagcatgg agcaggtgct gttccccaag cctggcccac     1080

tggagcccac gcagcgcctg ctgagccagc ttgagagggg catcctagtg gccagcaacc     1140

cccgaggcct cttcgtgcag cgcctttgcc ccatccccat ctcctggaat gcaccccagg     1200

ctccacctgg gccaggcccg catctgctgc ccagcaacga gtgcgtggag ctcttcagaa     1260

ccgcctactt ctgcagagac ttggtcaggt actttcaggg cctgggcccc ccaccgaagt     1320

tccaggtaac actgaatttc tgggaagaga gccatggctc cagccatact ccacagaatc     1380

ttatcacagt gaagatggag caggcctttg cccgatactt gctggagcag actccagagc     1440

agcaggcagc cattctgtcc ctggtgtaga gcctggggga cccatcttcc acctcacctc     1500

tttgttcttc ctgtctcctt tgaagtagac tcattcttca cacgattgac ctgtcctctt     1560

tgtgataatt ctcagtagtt gtccgtgata atcgtgtcct gaaaatcctc gcacacactg     1620

gctggtggag aactcaaggc taatttttta tccttttttt tttttaattt tgagatatac     1680

gccctctttc atctgtaagg gactaggaaa ttccaaatgg tgtgaaccca gggggccttt     1740

ccctcttccc tgacctccca actctaaagc caagcacttt atattttcct cttagatatt     1800

cactaaggac ttaaaataaa attttattga aagaggaa                             1838


<210> 2449
<211> 2592
<212> DNA
<213> Homo sapiens

<400> 2449
ccttctcttc tggtaggact caagagtagc cttcctcgag gacctgcctt tcccatttgc       60

tgcctgaagt taatgtttct tgctggccaa atcagggaca tgccggcatt agcgggatga      120

gtgggtgttc cggcagggat gtggtcattg acggccagtg agggcgagag taccacggcc      180

cacttcttcc ttggagctgg agatgagggg ctgggcaccc gtggaatagg catgaggcca      240

gaagagagtg acagcgagct ccttgaggat gaggaggatg aagtgcctcc tgaacctcag      300

atcattgttg gcatctgtgc catgaccaag aaatccaagt ccaagccaat gactcaaatc      360

ctagagcgac tctgcagatt tgactacctg actgttgtca ttctgggaga agatgtaatc      420

cttaatgaac ctgtggaaaa ctggccatcc tgccactgcc tcatctcttt ccactccaaa      480

ggctttcctc tggacaaagc tgttgcttac tccaagcttc gaaacccctt tcttatcaat      540

gatctggcca tgcagtatta catccaagat aggagggagg tgtaccggat cctgcaggaa      600

gagggtattg atctgcctcg atatgctgtg ctcaaccgtg atcctgcccg gcctgaggaa      660

tgcaacctga tagaaggtga agaccaagta gaggtcaatg gagctgtctt tcccaagccc      720

tttgtggaga agccagtgag tgcagaagac cacaatgttt acatctacta ccccagctca      780

gctggaggag gaagccagcg tctctttcgt aagattggca gccgaagcag tgtttactct      840

cctgagagca gcgtccgaaa gacggggtcg tacatctatg aggagtttat gccaacagat      900

ggcacagatg tcaaggtgta tacagtgggg ccagattatg cccatgctga agctagaaaa      960

tctccagctt tggatgggaa ggttgaacga gacagtgagg ggaaagagat tcaatatcca     1020

gtcatgctga ctgccatgga aaagctggtg gccaggaaag tctgcgtagc tttcaagcaa     1080

acagtttgtg gatttgacct tcttcgtgcc aatggtcatt cctttgtgtg tgatgtcaat     1140

ggctttagtt ttgtcaagaa ctcgatgaaa tactacgatg actgtgccaa gattctgggg     1200

aacaccataa tgcgggagct tgccccacag ttccagattc catggtccat ccccacggag     1260

gctgaggaca ttcccattgt tcccaccaca tctggcacta tgatggaact tcgttgtgtc     1320

attgcaatta ttcgtcatgg ggatcgtact cccaagcaga agatgaagat ggaagtgaaa     1380

cacccaaggt tttttgctct gtttgaaaaa catggtggct acaagacagg gaaattaaaa     1440

ctcaagcgac ctgagcagct ccaggaggtg ctggatatca caaggctgtt gttggctgaa     1500

ctggagaaag aaccaggtgg tgagatcgag gagaagactg gaaaactaga gcagctgaag     1560

tctgtactgg agatgtatgg tcacttctca ggtataaacc ggaaggtaca attgacttac     1620

taccctcatg gagtaaaagc ttctaatgag gggcaagatc cacagaggga aactctggcc     1680

ccatctctgt tgctggtact gaagtggggt ggagaactga ctcctgctgg ccgtgttcag     1740

gctgaggagc tggggcgagc ttttcgctgc atgtaccctg gaggacaggg tgactatgct     1800

ggcttccctg gttgtgggct gcttcgtctc catagcactt tccgccacga tctcaagatc     1860

tatgcctctg atgagggtcg tgttcagatg actgctgctg ccttcgccaa gggccttctg     1920

gctctagaag gggagctgac acccattttg gtgcaaatgg tgaagagtgc caacatgaat     1980

gggctactgg acagcgatgg ggattccttg agcagctgcc agcaccgggt gaaggctcgg     2040

ctgcaccata ttctacagca ggatgcgccc tttggccctg aggactacga tcagctggct     2100

cccaccagaa gtacttccct gctcaactcc atgactatca tccagaatcc tgtgaaggtc     2160

tgtgatcagg tatttgccct gatcgaaaac ctcacccacc agatccggga acgaatgcag     2220

gaccccaggt ctgtagacct gcagctctac cacagtgaga cactagagct aatgctacag     2280

cgttggagca agctggagcg tgactttcga cagaagagtg ggcgctatga tatcagtaag     2340

atccctgaca tctatgactg tgtcaagtat gatgtgcagc acaatgggag tctgggactt     2400

caaggcacag cagagttgct ccgtctctct aaggcactgg ctgatgtggt cattccccag     2460

gagtacggga tcagtcggga ggagaaactg gaaattgctg tgggcttctg tcttccactg     2520

ttgcggaaga tactacttga cctgcagaga acccacgagg atgagtctgt caacaagctg     2580

catcccctgt ga                                                         2592


<210> 2450
<211> 788
<212> DNA
<213> Homo sapiens

<400> 2450
aacctcacga ggccttacgt gcctagagcg gttcctctcc gtggcgccct accgccttcg       60

gcgcgaaggt ggctggtgcg taccgtcccg aaccctagga gccgagatcc cacccgcagg      120

accccaaaac ccaatgatcc tgcagcagcc cttgcagcga ggcccccagg gaggggccca      180

gcgcctcccg cgggccgcct tgggggtgac ttggggcctg gacgccagct cccctctccg      240

aggagctgtg cccatgagca ccaagcggcg cctggaggag gagcaggagc ctctgcgcaa      300

gcagtttctg tctgaggaga acatggccac ccacttctct caactcagcc tgcacaatga      360

ccacccctac tgcagccccc ccatgacctt ctccccagcc ctgcccccac tcaggagccc      420

ttgctctgag ctgcttctct ggcgctatcc tggcagcctc atccctgagg ccctccgtct      480

gctgaggctg ggggacaccc ccagtccccc ctaccctgca accccagctg gggacataat      540

ggagctctga gtgctggtgg acagtgcccc tcccaccttc cttcttcccc acaacagaag      600

agaccagcga ctcccgcaaa gggacaaggt tcctccctct cctgcagagt aggcatctgg      660

gcaccaagac cttccctcaa cagaggacac tgagcccaac ggagttctgg gatgggaggg      720

gtgggagcat gggaagggag gcatcccacc cccaagaaga actgaataaa gattgctgag      780

caaaggaa                                                               788


<210> 2451
<211> 5644
<212> DNA
<213> Homo sapiens

<400> 2451
tccggcggga ctcaagagta gccttcctcg aggacctgcc tttcccattt gctgcctgaa       60

gttaatgttt cttgctggcc aaatcaggga catgccggca ttagcgggat gagtgggtgt      120

tccggcaggg atgtggtcat tgacggccag tgagggcgag agtaccacgg cccacttctt      180

ccttggagct ggagatgagg ggctgggcac ccgtggaata ggcatgaggc cagaagagag      240

tgacagcgag ctccttgagg atgaggagga tgaagtgcct cctgaacctc agatcattgt      300

tggcatctgt gccatgacca agaaatccaa gtccaagcca atgactcaaa tcctagagcg      360

actctgcaga tttgactacc tgactgttgt cattctggga gaagatgtaa tccttaatga      420

acctgtggaa aactggccat cctgccactg cctcatctct ttccactcca aaggctttcc      480

tctggacaaa gctgttgctt actccaagct tcgaaacccc tttcttatca atgatctggc      540

catgcagtat tacatccaag ataggaggga ggtgtaccgg atcctgcagg aagagggtat      600

tgatctgcct cgatatgctg tgctcaaccg tgatcctgcc cggcctgagg aatgcaacct      660

gatagaaggt gaagaccaag tagaggtcaa tggagctgtc tttcccaagc cctttgtgga      720

gaagccagtg agtgcagaag accacaatgt ttacatctac taccccagct cagctggagg      780

aggaagccag cgtctctttc gtaagattgg cagccgaagc agtgtttact ctcctgagag      840

cagcgtccga aagacggggt cgtacatcta tgaggagttt atgccaacag atggcacaga      900

tgtcaaggtg tatacagtgg ggccagatta tgcccatgct gaagctagaa aatctccagc      960

tttggatggg aaggttgaac gagacagtga ggggaaagag attcgatatc cagtcatgct     1020

gactgccatg gaaaagctgg tggccaggaa agtctgcgta gctttcaagc aaacagtttg     1080

tggatttgac cttcttcgtg ccaatggtca ttcctttgtg tgtgatgtca atggctttag     1140

ttttgtcaag aactcgatga aatactacga tgactgtgcc aagattctgg ggaacaccat     1200

aatgcgggag cttgccccac agttccagat tccatggtcc atccccacgg aggctgagga     1260

cattcccatt gttcccacca catctggcac tatgatggaa cttcgttgtg tcattgcaat     1320

tattcgtcat ggggatcgta ctcccaagca gaagatgaag atggaagtga aacacccaag     1380

gttttttgct ctgtttgaaa aacatggtgg ctacaagaca gggaaattaa aactcaagcg     1440

acctgagcag ctccaggagg tgctggatat cacaaggctg ttgttggctg aactggagaa     1500

agaaccaggt ggtgagatcg aggagaagac tggaaaacta gagcagctga agtctgtact     1560

ggagatgtat ggtcacttct caggtataaa ccggaaggta caattgactt actaccctca     1620

tggagtaaaa gcttctaatg aggggcaaga tccacagagg gaaactctgg ccccatctct     1680

gttgctggta ctgaagtggg gtggagaact gactcctgct ggccgtgttc aggctgagga     1740

gctggggcga gcttttcgct gcatgtaccc tggaggacag ggtgactatg ctggcttccc     1800

tggttgtggg ctgcttcgtc tccatagcac tttccgccac gatctcaaga tctatgcctc     1860

tgatgagggt cgtgttcaga tgactgctgc tgccttcgcc aagggccttc tggctctaga     1920

aggggagctg acacccattt tggtgcaaat ggtgaagagt gccaacatga atgggctact     1980

ggacagcgat ggggattcct tgagcagctg ccagcaccgg gtgaaggctc ggctgcacca     2040

tattctacag caggatgcgc cctttggccc tgaggactac gatcagctgg ctcccaccag     2100

aagtacttcc ctgctcaact ccatgactat catccagaat cctgtgaagg tctgtgatca     2160

ggtatttgcc ctgatcgaaa acctcaccca ccagatccgg gaacgaatgc aggaccccag     2220

gtctgtagac ctgcagctct accacagtga gacactagag ctaatgctac agcgttggag     2280

caagctggag cgtgactttc gacagaagag tgggcgctat gatatcagta agatccctga     2340

catctatgac tgtgtcaagt atgatgtgca gcacaatggg agtctgggac ttcaaggcac     2400

agcagagttg ctccgtctct ctaaggcact ggctgatgtg gtcattcccc aggagtacgg     2460

gatcagtcgg gaggagaaac tggaaattgc tgtgggcttc tgtcttccac tgttgcggaa     2520

gatactactt gacctgcaga gaacccacga ggatgagtct gtcaacaagc tgcatcccct     2580

ctgttatctc aggtactccc gaggcgtgct ctccccaggt cgccacgttc gaacgcgtct     2640

ctatttcacc agtgagagcc atgtccactc cctgctcagt gtcttccgtt atggaggact     2700

tcttgatgag acccaggatg cacaatggca gcgagctttg gattatctta gtgccatctc     2760

agagcttaac tacatgaccc agattgtcat catgctttat gaggacaaca cacaggatcc     2820

cttatcagag gaacggttcc atgtggagct acacttcagc cccggagtga aaggtgttga     2880

ggaagaaggc agtgccccgg ctggctgtgg attccgtcca gcctcttctg agaatgagga     2940

gatgaaaacc aaccaaggca gtatggagaa cctgtgtcca ggaaaggcat cagatgaacc     3000

agaccgggca ttgcagactt caccccagcc tcctgagggc cctggccttc cgaggagatc     3060

acccctcatt cgtaaccgaa aagctggttc catggaggta ctttctgaga cttcatcctc     3120

gaggcctggt ggctaccggc tcttttcatc ttcacggcca cccacagaaa tgaagcagag     3180

tggcctaggc tcacagtgca cagggctgtt cagcaccaca gtgctgggtg gctcctccag     3240

tgccccgaat cttcaggact acgcccgcag ccatggcaaa aagctaccac ctgccagtct     3300

gaagcaccga gatgagctct tgtttgtccc ggccgtaaaa cgattttctg tgtcgtttgc     3360

aaagcatccg actaacgggt ttgaagggtg ttccatggtg cctaccatct accctctgga     3420

aacactgcat aatgcccttt ccctacgtca agtgagtgaa ttcttgagta gagtctgcca     3480

gcgccacact gatgcccagg cacaggcatc tgcagccctc tttgattcca tgcacagcag     3540

ccaggcctca gataacccat tttctccacc acgtactctt cattcacctc ccctgcaact     3600

ccagcagcgc tctgagaagc ccccttggta cagcagtggc ccttctagca ctgtgtccag     3660

tgctggtcct tcttccccta ctacagtaga tggtaactcc caatttggct tcagtgatca     3720

accctcccta aattcacacg tggctgaaga acatcaaggc cttgggctgc tccaggagac     3780

ccctgggagt ggagcacaag agctctccat agaaggggag caagagcttt ttgaaccaaa     3840

tcagtcccca caggtgccac ctatggaaac cagccagcca tacgaggagg tcagccagcc     3900

atgtcaggag gtccctgaca tcagccagcc atgccaggac atttctgagg cgctcagcca     3960

gccatgtcag aaggtccctg acatcagcca gcaatgccag gagaaccatg acaatggtaa     4020

ccacacatgc caggaggtcc ctcacatcag ccagccatgc cagaagtcca gccaactgtg     4080

ccagaaagtc tctgaggaag tttgccagct atgtctggag aactccgagg aggtcagcca     4140

gccatgccag ggggtctctg tggaggttgg caagctggtc cataagttcc atgtaggggt     4200

tggtagcttg gtccaggaaa cccttgtaga agttggcagc ccagctgaag agatccctga     4260

ggaggtcatc cagccatacc aggagttctc tgtggaggtt ggcaggctgg cccaggagac     4320

ttctgcgatc aatctgttat ctcagggcat ccctgagatt gataaaccat cccaagagtt     4380

ccctgaggag attgatctgc aggcccagga ggtccctgag gagataaatt agaagtcctg     4440

ggtggtccct gaagtgattg atcagctgcc tggagagggt attcctcaag cccagcatcc     4500

atctggtgat ccaaaccctc agagccagtc tctagcccat gaccagcact caccccttcc     4560

accagcaaca tgtgattaat tttctcatta gtggtatcac actataccag ccatttgagc     4620

cagcaacctt ttctgttggc taactcactg gccagctctc accagcggtg tctggggaag     4680

tagttctctt tgtatgaagc atacctgtgc cagagctgtg gttgaggagg agccagtttt     4740

aggttcgaag aagccattgg ctcctcactt agccattaga cttgaatagg atttccttgg     4800

ggtgggttgg tctgtcatta cccagccttc tctgagcatc ctaggaaatc acagattgtt     4860

aaaggaaatg ccgcttcact gctgaagaca ccatctggcg acagcaaatg caaaagaggg     4920

gactctaggg tcttcacttt tctggggaaa tgttcacgac ttctcaaggt acgcttagac     4980

catatgtgca ttcaggggac tcttgtcttt gccagcactc ctcaggtgag cccgggatgg     5040

ctatctgaaa tgtctggaaa atagagtccc ttccccaaac atctgacatg gccactaaat     5100

ctttagactt gccttataga tccttccata tcatccccaa gtgccccttc tgcctcagtc     5160

ctgttcctct gggcaatagc tctagggaaa agtaggtatt agactgctgt gcaaaattca     5220

gagcaactac ttaaaatgct ctagaggatt cttagccagt ctgtgaaagt gggcctcctc     5280

tgtggtgggg ctgtttggct taggagatgc tgtagtagta gagataatca ggttctattt     5340

taagcaatca gcagagatca atattgtaca gatacaagca aaggtttaat aaatatatat     5400

atatatattt atttctgtag ttgtgccagg gacagactgg ccaaagacca aacactgcag     5460

ggtccccaag aaatttgtcc ttatatcatt gtgtctgagg gccagatatg attatgaagc     5520

tttttccaaa gatccaggga tgggaatggg agtgggtagg aggggtaatg cggtcattgg     5580

agtcgggggc tggaacatta tgagtgctca ataaatataa actaatgaga atggtggtga     5640

tgga                                                                  5644


<210> 2452
<211> 928
<212> DNA
<213> Homo sapiens

<400> 2452
cttttccaag cggctgccga agatggcgga ggtgcaggtc ctggtgcttg atggtcgagg       60

ccatctcctg ggccgcctgg cggccatcgt ggctaaacag gtactgctgg gccggaaggt      120

ggtggtcgta cgctgtgaag gcatcaacat ttctggcaat ttctacagaa acaagttgaa      180

gtacctggct ttcctccgca agcggatgaa caccaaccct tcccgaggcc cctaccactt      240

ccgggccccc agccgcatct tctggcggac cgtgcgaggt atgctgcccc acaaaaccaa      300

gcgaggccag gccgctctgg accgtctcaa ggtgtttgac ggcatcccac cgccctacgg      360

aaacaggccg agaagaacgt ggagaagaaa attgacaaat acacagaggt cctcaagacc      420

cacggactcc tggtctgagc ccaataaaga ctgttaattc ctcatgcgtt gcctgccctt      480

cctccattgt tgccctggaa tgtacgggac ccaggggcag cagcagtcca ggtgccacag      540

gcagccctgg gacataggaa gctgggagca aggaaagggt cttagtcact gcctcccgaa      600

gttgcttgaa agcactcgga gaattgtgca ggtgtcattt atctatgacc aataggaaga      660

gcaaccagtt actatgagtg aaagggagcc agaagactga ttggagggcc ctatcttgtg      720

agtggggcat ctgttggact ttccacctgg tcatatactc tgcagctgtt agaatgtgca      780

agcacttggg gacagcatga gcttgctgtt gtacacaggg tatttctaga agcagaaata      840

gactgggaag atgcacaacc aaggggttac aggcatcgcc catgctcctc acctgtattt      900

tgtaatcaga aataaattgc ttttaaag                                         928


<210> 2453
<211> 1734
<212> DNA
<213> Homo sapiens

<400> 2453
gcgctgccta cggaggtggc agccatctcc ttctcggtaa gtgttaatcc gtggcaatcc       60

gcattcctgc gggattcatc tggccccgtc gcccagtggt gcggaggcct ccccttcagc      120

gcggtagtgt ctgtgggtat tgttattgtc agcttactgg agcgtgtaca ggaacagaac      180

gaagccgccg agttgatagg gctttgcgtc ccagagcctc ctgccctccg cctgtattca      240

gagctgcggg ctgcttgttt gttccttggc ggtggagggt gctagttgag gccagacttc      300

ggggtctcct gggggccgtg ggacgaccag gggtggccca gcttgacagc tttcagctgg      360

gatctgtgga tcccagcgct caccaatgtc ggcccacgtg tattcgttca tgccatggcc      420

ggcttcttcc gctgcagtct ctggcccgag ggctgctgct gcgggaccgc caaggaaaga      480

cgagctgtag gtcggctggt ccagctgcag gcagaaattc tggtagtatc tctgggaata      540

tgaagatgca actgccccca ccttgccttc gaggatatca tgggccagaa ggcagagtcg      600

ttttgaatac gtggttcatt gagtacccac tctgggccag ttgatggctg cgaagagagc      660

agaaggggtg ctgctgtagg aaatcaatgg ctcggaagac cacactgagg aaggtgtgag      720

ttgatactgg aagatctcca ggtttgaggc atcttcagag gtatatggtg gttttgtgtg      780

tgttgagggt gtggtagcgc agcagctccc tagggaatta gaaggtttta ttgaacattt      840

accctgtgac aggcactgca ggcattcagc gcgcagtgtc atcttcattt tacaggtgag      900

gaaaagactc aggttcaagt agatggtcaa ggccagtact accggaagga ccatctgggg      960

gttcggacac tggtggggtg ggatttgctg ccccttgcaa attgagagtg tcttggggtc     1020

agttttgatt tgctcagctg ttggcattct ttgggctctg agtgggtgag gtgacccttg     1080

acctcctggg atcgcatctg gagagtgcct agtattctgc cagcttcgga aagggaggga     1140

aagcaagcct ggcagaggca cccattccat tcccagcttg ctccgtagct ggcgattgga     1200

agacactctg cgacagtgtt cagtccctgg gcaggaaagc ctccttccag gattcttcct     1260

cacctggggc cgcttcttcc ccaaaaggca tcatggccgc cctcagaccc cttgtgaagc     1320

ccaagatcgt caaaaagaga accaagaagt tcatccggca ccagtcagac cgatatgtca     1380

aaattaagcg taactggcgg aaacccagag gcattgacaa cagggttcgt agaagattca     1440

agggccagat cttgatgccc aacattggtt atggaagcaa caaaaaaaca aagcacatgc     1500

tgcccagtgg cttccggaag ttcctggtcc acaacgtcaa ggagctggaa gtgctgctga     1560

tgtgcaacaa atcttactgt gccgagatcg ctcacaatgt ttcctccaag aaccgcaaag     1620

ccatcgtgga aagagctgcc caactggcca tcagagtcac caaccccaat gccaggctgc     1680

gcagtgaaga aaatgagtag gcagctcatg tgcacgtttt ctgtttaaat aaat           1734


<210> 2454
<211> 1749
<212> DNA
<213> Homo sapiens

<400> 2454
aggggttacg acccatcagc ccttgcgcgc caccgtccct tctctcttcc tcggcgctgc       60

ctacggaggt ggcagccatc tccttctcgc tggcgattgg aagacactct gcgacagtgt      120

tcagtccctg ggcaggaaag cctccttcca ggattcttcc tcacctgggg ccgcttcttc      180

cccaaaaggc atcatggccg ccctcagacc ccttgtgaag cccaagatcg tcaaaaagag      240

aaccaagaag ttcatccggc accagtcaga ccgatatgtc aaaattaagc gtaactggcg      300

gaaacccaga ggcattgaca acagggttcg tagaagattc aagggccaga tcttgatgcc      360

caacattggt tatggaagca acaaaaaaac aaagcacatg ctgcccagtg gcttccggaa      420

gttcctggtc cacaacgtca aggagctgga agtgctgctg atgtgcaaca aatcttactg      480

tgccgagatc gctcacaatg tttcctccaa gaaccgcaaa gccatcgtgg aaagagctgc      540

ccaactggcc atcagagtca ccaaccccaa tgccaggctg cgcagtgaag aaaatgagta      600

ggcagctcat gtgcacgttt tctgtttaaa taaatgtaaa aactgccatc tggcatcttc      660

cttccttgat tttaagtctt cagcttcttg gccaacttag tttgccacag agattgttct      720

tttgcttaag cccctttgga atctcccatt tggaggggat ttgtaaagga cactcagtcc      780

ttgaacaggg gaatgtggcc tcaagtgcac agactagcct tagtcatctc cagttgaggc      840

tgggtatgag gggtacagac ttggccctca caccaggtag gttctgagac acttgaagaa      900

gcttgtggct cccaagccac aagtagtcat tcttagcctt gcttttgtaa agttaggtga      960

caagttattc catgtgatgc ttgtgagaat tgagaaaata tgcatggaaa tatccagatg     1020

aatttcttac acagattctt acgggatgcc taaattgcat cctgtaactt ctgtccaaaa     1080

agaacaggat gatgtacaaa ttgctcttcc aggtaatcca ccacggttaa ctggaaaagc     1140

actttcagtc tcctataacc ctcccaccag ctgctgcttc aggtataatg ttacagcagt     1200

ttgccaaggc ggggacctaa ctggtgacaa ttgagcctct tgactggtac tcagaattta     1260

gtgacacgtg gtcctgattt tttttggaga cggggtcttg ctctcaccca ggctgggagt     1320

gcagtggcac actgactaca gccttgacct ccccaggctc aggtgatctt cccacctcag     1380

ccttccaagt agctgggact acagatgcac acctccaaac ctgggtagtt tttgaagttt     1440

ttttgtagag gtggtctagc catgttgcct aggctcccga actcctgagc tcaagcaatc     1500

ctgcttcagc ctcccaaagt actgggatta caggcatctt ctgtagtata taggtcatga     1560

gggatatggg atgtggtact tatgagacag aaatgcttac aggatgtttt tctgtaacca     1620

tcctggtcaa cttagcagaa atgctgcgct gggtataata aagcttttct acttctagtc     1680

tagacaggaa tcttacagat tgtctcctgt tcaaaaccta gtcataaata tttataatgc     1740

aaactggtc                                                             1749


<210> 2455
<211> 803
<212> DNA
<213> Homo sapiens

<400> 2455
tggaaatcta aagggaatgg tgaagttgca ccgtaagggg aaggtgactg aggagctgaa       60

actgactgag gggctgaagc atttcggaca ggagaaagga tcaggaggag acagagcgga      120

gaatggagcc tcagggctac ccagcgtttg gctgggatca ctcgcttcac aaaaggaaaa      180

gacttcctcc tgtgaagaga tccttagtat actacttgaa gaaccgggaa gtcaggctac      240

agaatgaaac cagctactct cgagtgttgc atggttatgc agcacagcaa cttcccagtc      300

tcctgaagga gagagagttt caccttggga cccttaataa agtgtttgca tctcagtggt      360

tgaatcatag gcaagtggtg tgtggcacaa aatgcaacac gctatttgtc gtagatgtcc      420

agacaagcca gatcaccaag atccccattc tgaaagaccg ggagcctgga ggtgtgaccc      480

agcagggctg tggtatccat gccatcgagc tgaatccttc tagaacactg ctagccactg      540

gaggagacaa ccccaacagt cttgccatct atcgactacc tacgctggat cctgtgtgtg      600

taggagatga tggacacaag gactggatct tttccatcgc atggatcagc gacactatgg      660

cagtgtctgg ctcacgtgat ggttctatgg gactctggga ggtgacagat gatgttttga      720

ccaaaagtga tgcgagacac aatgtgtcac gggtccctgt gtatgcacac atcactcaca      780

aggccttaaa ggacatcccc aaa                                              803


<210> 2456
<211> 1552
<212> DNA
<213> Homo sapiens

<400> 2456
atgaccaggc tggggacagt tcccaggaag gccttggaga tgagctgtgc catccagaat       60

cagctggccc gcatcctggc cgagtttgag atgaccctgg agagggacgt cctgcagcca      120

ctcagcaggc tgagtgagga ggagctgcca gccatcctca aacacaagaa aagcctccag      180

aagctcgtgt ccgactggaa cacactcaag agcaggctca gtcaggcaac caagaattca      240

ggcagcagtc aaggcctagg aggcagcccg ggtagtcaca gccatacgac catggccaac      300

aaggtggaga cgctgaagga ggaggaggag gagctgaaga ggaaagtgga gcaatgcagg      360

gacgagtact tggctgacct gtaccacttt gttaccaagg aggactccta tgccaactac      420

ttcattcgtc tcctggagat tcaggccgat taccatcgca ggtcactgag ctcgctggac      480

acagccctgg ctgagctgag ggagaaccac ggccaagcag accactcccc ttcgatgaca      540

gccacccact tccccagggt gtatggggtg tcgctggcaa cccacctgca agagctgggc      600

cgggagattg ccctgcccat cgaggcctgc gtcatgatgc tgctttctga gggcatgaag      660

gaagagggtc tcttccgtct ggctgctggg gcctcggtgc tgaagcgtct caagcagaca      720

atggcctcgg acccccacag cctggaggag ttctgctccg acccgcacgc tgtggcaggt      780

gccctcaagt cctatctgcg ggagctgcca gagcctctga tgaccttcga cctctatgat      840

gactggatga gggcagccag cctgaaggag ccaggggccc ggctgcaggc cctccaagag      900

gtgtgcagcc gcctaccccc cgagaacctc agcaacctca ggtacctgat gaagttcctg      960

gcacggctgg ccgaggagca ggaggtgaac aagatgacac ccagcaacat cgccatagtc     1020

ctgggaccca acttgctgtg gccacctgag aaagaagggg accaggccca gctggatgca     1080

gcctccgtgt cttccatcca ggtggtgggc gtcgtcgagg cgctgatcca gagcgcagac     1140

accctcttcc ctggagacat caacttcaac gtgtcaggcc tcttctcagc tgttaccctc     1200

caggacacag tcagtgacag gctggcctct gaggaacttc cgtccactgc cgtgcccacc     1260

ccagccacca ccccggctcc ggctccggct ccagctccag ctccggcccc agccttggct     1320

tcagcagcta ccaaggaaag gacagagtct gaggtgcctc ccagaccagc ctcccccaag     1380

gtcaccagga gtcccccgga gacagctgcc ccagtggagg acatggctcg gaggagtcct     1440

aggggagcca ccggaaggaa ggagaggttt gcctgctcct acgggactga ttcttctctt     1500

gccgacatgt tttttgtaag gctggtaaat aaattatttt ggacaaaact gg             1552


<210> 2457
<211> 2010
<212> DNA
<213> Homo sapiens

<400> 2457
ggcccgcggg actcagacca gcggggagcg cggcctccgc ccttggggcc ctcccgccgg       60

gccggagacc caagccccca acgccaggcc ctgccctgga agcgctcgcg gcccggcgcc      120

tggacggggg agttgctgct ctttggcgta aattgcaatc gattagggat cgtttctcag      180

aatcaagtta gaagtgagag ttcagataag tgaggccgcc attgctgctt tgaacacctc      240

agaaggggag aatggattta tcaggagtga aaaagaagag cttgctagga gtcaaagaaa      300

ataataaaaa gtccagcact agggctcctt cacctaccaa acgcaaagac cgctcagatg      360

agaagtccaa ggatcgctca aaagataaag gggccaccaa ggagtcgagt gagaaggatc      420

gcggccggga caaaacccga aagaggcgca gcgcttccag tggtagcagc agtaccaggt      480

ctcggtccag ctcgacttcc agctcaggct ccagcaccag cactggctca agcagtggct      540

ccagctcttc ctcagcatcc agccgctcag gaagctccag cacctcccgc agctccagct      600

ctagcagctc ttctggctct ccaagtcctt ctcggcgcag acacgacaac aggaggcgct      660

cccgctccaa atccaaacca cctaaaagag atgaaaagga gaggaaaagg cggagcccat      720

ctcctaagcc caccaaagtg cacattggga gactcacccg gaatgtgaca aaggatcaca      780

tcatggagat attttccacc tatgggaaaa ttaaaatgat tgacatgccc gtggaaagga      840

tgcatcccca tctgtccaaa ggctatgcgt acgtagagtt tgagaatcca gatgaagccg      900

agaaggcgct gaagcacatg gatggaggac aaattgatgg ccaggagatc actgccaccg      960

ccgtgctggc cccctggcct aggccacccc ccaggagatt cagccctccc aggagaatgt     1020

tgccaccacc gcctatgtgg cgcaggtctc ccccacggat gaggagaagg tcccgctccc     1080

cgaggcgcag gtcccccgtg cgccggagat cacggtcccc gggccgccgc cgccacagga     1140

gccgctccag ctccaactcc tcccgataaa caggccactg aagctctcgc ccctgtaact     1200

tataccccac ccagctcagt tttgtcactt ttctagccaa aggaagacca gtaggaaagc     1260

aaacccttga ctctggcagg atttgcaggc agcaggcagc acccctctgc cagccgggcc     1320

ccggctgcag aagtgctgtt ggtttggatg ctgtgtgcct gtcaagattc cctccggttt     1380

tctggctaga aagctcatcc gtttccggtt tctaagagtc agttcagtgg cagagccacc     1440

agggaaaagt gaggctcttg ggggtggttt gaccctgctt acctgggagc acacttttcc     1500

cttccccgat gacctgggat ggtggccagg ccgtgccctt gctgttgctg ggcagtgtcc     1560

ttttggaaag ggagctgccc caggctttag tgcagctgcc aaccctgtta ggcctggcct     1620

ctcgaggcct cttctgacct caagggtcac accccctcaa agatcctctc acccatggta     1680

gttgctgctc gtggttctgt ctgtccgtgc accgatgcac acaccgcacc ccaccactgt     1740

actctgaaat tggcgagtga gtggagagcc agctctgcgg agtcatcacg cagccatggt     1800

tgtgcctgcc gttcatggtg gtctttcagg ttatcttggc aacatgtaca ttgcttttat     1860

tttttttctt ttttgctttc attgtacagt cagtactata aaatttctct tttgagtttt     1920

atacctttgt agcattttag atgacattgt gtttgtactt tgttgtgtag agtggaagaa     1980

ttgtgttgaa taaacccaag atcggaatgc                                      2010


<210> 2458
<211> 1467
<212> DNA
<213> Homo sapiens

<400> 2458
tggtactgag gaggcctagc agggtgaagg ccacggtcgc ggccttcacg ggttcctcgg       60

ccgtcctgag tcccaaatcc caagctggag ccgttcagct cccctccacc gcttagagat      120

ttggggggct ctggccccgt ccttgcggac cattccgagg ggagtccaga ggtgtcagta      180

attaacactg tggatacctc ccatgaggac atgattcacg acgcccagat ggactactat      240

ggcacccgcc tggcaacctg ctcatcagac aggtccgtca aaatctttga tgtgcgcaat      300

ggagggcaga tccttatcgc cgacctcagg ggtcatgagg gtcctgtgtg gcaagtggcc      360

tgggctcacc ccatgtacgg caacatcctg gcatcgtgct cctatgaccg gaaagtcatt      420

atctggagag aggaaaacgg cacctgggag aagagccacg agcatgcggg acacgactcc      480

tcagtgaact cggtgtgctg ggccccccat gactacggcc tgatcctggc ctgtgggagc      540

tcggatgggg ccatctccct gctgacttac accggggaag gccaatggga agtaaagaag      600

atcaacaacg ctcacaccat tggctgcaat gccgtcagct gggcccctgc tgttgtacct      660

ggaagcctca tagaccaccc atcggggcag aaacccaatt acatcaagag gtttgcatca      720

ggtggctgtg acaacctcat caagctgtgg aaggaggagg aggacggcca gtggaaggag      780

gagcagaagc tagaagcgca cagtgactgg gttcgagatg tggcctgggc cccctccatc      840

ggcctgccca ccagcaccat cgccagctgc tcccaggatg gtcgtgtgtt catttggacc      900

tgtgatgatg cctcaagcaa tacgtggtcc cctaaattgt tgcacaagtt caacgatgtg      960

gtgtggcatg tgagctggtc catcacagcc aacatcctgg ctgtctctgg tggagacaat     1020

aaggtgaccc tgtggaagga gtcagttgat gggcagtggg tgtgcatcag tgatgtcaac     1080

aagggccagg gctccgtatc agcatcagtg acagagggcc agcagaacga gcagtgacaa     1140

gacaggtggg gcctggctcc ccacccgcca gctccaggac tgccccttcc tgggccaact     1200

aaccagacaa ctgggaagag cccccaactc caacaggatt attttcccag gaggagttac     1260

agatgcagcc acagattgat catctgcctt aacgtgatcg gagatgcttt gtaatctact     1320

gtccagctga aagcactcat gttacgagga agaaactaca agtgatgttc aaatctattt     1380

tgggtcattt ttatgtacct ttgggttcag gcattatttg gggggttttg tttccaaagg     1440

aactaaataa agtcatattg cttataa                                         1467


<210> 2459
<211> 7122
<212> DNA
<213> Homo sapiens

<400> 2459
cgcgactggc cttgagggag agctggggcc tgctcccgga gagatacggc tatgtcgatc       60

gaaatcgaat cttcggatgt gatccgcctt attatgcagt acttgaagga gaacagttta      120

catcgggcgt tagccacctt gcaggaggag actactgtgt ctctgaatac tgtggacagc      180

attgagagtt ttgtggctga cattaacagt ggccattggg atactgtgtt gcaggctata      240

cagtctctga aattgccaga caaaaccctc attgacctct atgaacaggt tgttctggaa      300

ttgatagagc tccgtgaatt gggtgctgcc aggtcacttt tgagacagac tgatcccatg      360

atcatgttaa aacaaacaca gccagagcga tatattcatc tggagaacct tttggccagg      420

tcttactttg atcctcgtga ggcataccca gatggaagta gcaaagaaaa gagaagagca      480

gcaattgccc aggccttagc tggcgaagtc agtgtggtgc ctccatctcg tctcatggca      540

ttgctgggac aggcactgaa gtggcagcag catcagggat tgcttcctcc tggtatgacc      600

atagatttgt ttcgaggcaa ggcagctgtc aaagatgtgg aagaagaaaa gtttcctaca      660

caactgagca ggcatattaa gtttggtcag aaatcacatg tggagtgtgc tcgattttct      720

ccagatggtc agtatttggt cactgggtct gttgatggat tcattgaagt atggaacttt      780

actactggaa aaatcagaaa ggatcttaag taccaggccc aagataactt tatgatgatg      840

gatgatgctg tcctctgcat gtgtttcagc agagatacag aaatgttagc aactggggcc      900

caagatggaa aaatcaaggt gtggaagatt cagagtggac aatgtttaag gagatttgag      960

agggcacaca gtaagggtgt cacctgtcta agcttttcta aggatagcag tcagatcctt     1020

agtgcttctt ttgaccagac aattagaatt catggtttaa aatctgggaa aaccctgaag     1080

gaatttcgtg gccattcctc ctttgttaac gaagcaacat ttacacaaga tggacattac     1140

attattagtg catcctctga tggcactgta aagatctgga atatgaagac cacagaatgt     1200

tcaaatacct ttaaatccct gggcagcacc gcagggacag atattaccgt caacagtgtg     1260

attctacttc ctaaaaaccc tgagcacttt gtggtgtgca acagatcaaa cacggtggtc     1320

atcatgaaca tgcaggggca gattgtcaga agcttcagtt ctggtaaaag agaaggtggg     1380

gactttgttt gctgtgccct ctctccccgt ggtgaatgga tctactgtgt aggggaggac     1440

tttgtgctct actgtttcag tacagtcact ggcaaactgg agagaacttt gacagtgcac     1500

gagaaggatg tgattggtat tgcacatcac cctcatcaga acctgattgc tacctacagt     1560

gaagatggac tcctaaagct ctggaaacca taattcaact tttcttttta aatcagctcg     1620

aaagcatgta cttaaatgaa gcatattcat gtaatgtgct tttttttttt tttgccagct     1680

tttctaagca aatagattgt ctgaattagt cacagaataa ttttgtgaaa attcatgttt     1740

aagtagcaac taccctttct ttttttatat atttttaagg tattagttta tcttcttcta     1800

actggtgcag tcacttaatg ttttcattaa tcttcgacct ggagagtgaa atactgatat     1860

ttctagaaaa aaattctact cctctgatta tttgaaatgc tgaggaaaat gtccctccca     1920

tagtaaaact tgtaaataag gaactatatc atattcagta gctgtgttct gttccatctt     1980

tttttttttt tttgagatgg agttttgctt gttgcccagg ctggagtgca gcggcacgat     2040

cttggttcac tgcaacctcc gcctcccagg ttcaagcgat tctcttgcct cagcctcccg     2100

agtagctggg gactacaggt gtgcgacacc atgcctggct aatttttttg tatttttagt     2160

agagatgggg tttcaccatg ttggccaggc tggtctcaaa ctcctgacct caaaggatcc     2220

acccgccttg gcctcccaaa gtgctgggat cacaggcgtg agccaccatg cccggcccat     2280

cttttttttt tttttttttt ttaaagatgt taataaactt tatacctttc tggagacttt     2340

gttctaaaat gtacataaat gctcatctag ttaacatatt tacttagaat gtgggaggag     2400

gagtcacatt attatccctg aatctcaagt acagcagaag tgaattcctg ggatagtagg     2460

atagactaac atgtaaaaag gccaggtgat gcataggttc tcatttcact gccctcagcc     2520

ttcctctcct tctgagctgt gccttctcac atgttcagtc aactccaggg aatattgtct     2580

ccatcttctg gatagaacta gttgcaggat ccgttacaag aattcagagt tttggcatct     2640

cccctttgta tgttgtagga gaaggtttgg cattgaaaat gtgctgttgt tccaaagaaa     2700

aattagcaaa ggacttgaga tttagaaaag tctcctttgt aatgtgcatc attaccagtt     2760

atctaaagaa aaacatgtaa aagccaacaa aacccttgaa aatattttgc atatggatgt     2820

ctgtttcacg tttcaactga agatgtatag agcacctctg atgatgagga agataccatg     2880

ctaggcagta ctttcaagaa cgtgagttct tatttctgca ggccttttgt gccccctttt     2940

aaatgttagc atttattagg tacaaactag tggggaaggt ttttttaaaa agttttgcag     3000

tcttgtaatt taccttttta aaaaatttat tttatttttc tgagatggag tcttgctctg     3060

ttgcccaggc tggagtgcag tggtgccatc tcagctaact gcaacttcca cttcccaggt     3120

tcaagcgatt ctcctgcctt agcctcccaa gtagctggga ctacaggcgc atgccagcat     3180

gcctggctaa tttttgtatt tttagtagag cgggggtttt gccatgttgg ccaggctggt     3240

cttgaactcc tgacctcagg tgatccgcct gccctggcct cccaaagtgc tgggattaca     3300

ggcatgagcc actgcgccca gccttgtaat ttacctttga tggtgacctg aaatgcagta     3360

tgatcctata tgtggcacgt agtaatgttc agtgtttgct gaattaattc tgggcagcac     3420

taagaaatcc ctctttccca gtcatattct ataacacatt tcccatttgc cacaaaacct     3480

gcagcttttt ggtccaggta atgacatttg ctgccatttt gatgatttaa aaatggtcgt     3540

gggagttgaa catagtcatg aattcaggat tcctgagcat gtagacagtc atcccagtgg     3600

aaagacacgt tcacttaaga gaagtttaag ttagaggaaa cagtttatgc taaaaaaatt     3660

tttagaaaag tccttgagaa tttttgattt agtcttgacc tcatgaagct ggtagttatg     3720

atgtgcatag tttgtatcac cgtttatgaa gatggagaat ctagtcagca cgtgttggtt     3780

tattctagga atttttaggg aacacttctg ttgctggcac caggtgatga atatggttaa     3840

aaaaagactc gtttctgcct aaacataggg aagaagagca aattaaaagg agtaattaaa     3900

actgataaaa gctcaagtta cctttgtgat gatgaggcgg gcagttaacg cgaaagggtt     3960

gggaaaggct tcctggaggg actagggggc ggtctaagca cagggaacct aaccggggac     4020

tccagtgtgg cacagcggca aggtatgtgc tgggcaaaat gataggtgtc ttgggagacc     4080

aggcaaagag agctggatta ggagccgtta agtatatatt tttcttcttt ttaaataaaa     4140

taatgcactg ggtgaacatg taaacgctaa gttgaaaatc tgcctttccc aggtaaccct     4200

tgttaatctt tctacaactt catttcgtac aaacctgaaa aacacactga ttttgtcttt     4260

aaatgggcac acgctgctta cactcctcgg cgcctagcct ttctgaagcc ccacgcggcc     4320

gtccctccag cattgaaggc tggggcagcc cagctcccct ccagcgccct tacagccaga     4380

ccgcggcggg gtcgggccgc gcacgcgcag ggcggacggc cggatctggg gcgccgctgc     4440

tccgggtggt cggaggtagg agtcccatct tgggtccagg gccggtagag ccccttaccg     4500

ggggtaggga gactgcgcac ccgctagagc caactgtcag ggcctgcaga cgtcgggtga     4560

cgtcactgtt acaaaattgg cggtcacatc gtcttaaggg ccggtggcag cggctgcgcg     4620

aacgggagtt ggctgccggg aatcagtgct cacttccttc tgaattgggc gtgtgcagtc     4680

ggttcctagg gaagtgctct gctgcagcca ccagatttaa cggatgctgc tctctagcac     4740

ttaacataga agctaaacta cctggcgtta aaattaattc catgagcata aggacatttg     4800

tcctatcccc tattctgctg ttgaattaat gactggaaaa cattgcgcgg aggtatttgg     4860

gagtagtatg gctttttttt tttttttttt tttaacagca aatggtataa atctcaggta     4920

caattcagta tcttcttcac cagttgtttt ttttcagcat gtattattac taccactaac     4980

ggcctctgtt gagcccttcc ttgctatgta agcagccata tttaattctc agaacaatgt     5040

aatgagggtg cgcaaatgca catgaagaaa caggtttcca gacgtgaggc acctaactca     5100

gtccaacttg cacgaagctc gcattgaaaa ccagatgtga ctccgaagct aggttttttt     5160

tctctcttgc ctcactctca atattgctgt cagttcctcc tcaatcttta ggtttgggca     5220

gggacaaaga atacatggat tgttcctcca catgctgcaa acacattcac ctaagcagag     5280

cacaggtagt gagatgagta gagagaactg aattagagga ttctggatgt cagtctttgc     5340

tgtcacttct tttggcttgt gctagaacag tggttcttac aagtgtcacg tgatagacac     5400

attctaaggt cctatcccag acctacagaa tcagaaattg gtggtggggc ccagcaagcg     5460

tgctcaaatt tgagagcagg tagactacag ggtagtttcc gcatatacaa aaggtgtttt     5520

aattcttgct gtcagtctca gaagtttcat gctgagataa ccaaatttaa atgataaagg     5580

tgcaagactg actcttaaaa tcacattttt tcaaattgcc atagcttgct agtgttctca     5640

ttcactgtgc ttttacagct tcattttcca ctattttaag agaagaaatt gctatgaagt     5700

gtatgtccaa gtgaggaagt tccctggtct gaggttgttt aaaacttaca ataggccggg     5760

cacggtggct caagcctgta atcccagcac tttgggaggc cgaggtgggt ggatcacgag     5820

gtcaggagtt caagaccacc ctggccaaca tggtgacacc ctgtctctac taaggataca     5880

aaattagccg ggcatggtgg cacacgcctg tagtcccagc tacctaggag gctgaggcag     5940

gagaatagct ggaacccggg aggcagaggt tgcagtgagc tgagactgtg ccactgcact     6000

ccagcctggg tgacagagca agacttggtc tcaaaaacaa aaaacaaaaa aaccaaactt     6060

ggaatagcaa gggctgccca ttatttaacc ttccacggca attttaacag tggtattctg     6120

ttccaagtgg ttaatattaa atccatgtgt cagtgttggt ggctttcaac cttggctgcg     6180

cataatcatt ttgatgctta ggctacaccc agccgagtta tacagaatcc ctggagggtg     6240

ggacctgatg agtgttttaa tgtttcccgg gtaattccaa tggtagccaa ggttaagaac     6300

cagtaccgta cgtacaaaaa agttgagaag ctaatttcac gtacagaaaa tttgccactg     6360

ttccaagagc actctcaagc gacataattg gcctctactc ctattcccta caagtatgaa     6420

tgggcaggag aagcatcaca gagaaagcag agttagtgct ggaacttgta tttttgtgga     6480

tgatgacctt ggttaatgtt ttttcatagg ctctgtttca taggctttgt tttttcatag     6540

gctctccctc attacattgt tctgagaatt aaatatggct gcttacatag taatgaaggg     6600

ttcaacagag gctgttagtg gtagtaataa tacaagctga aaaactacac agacaaacct     6660

atcagtttct gcctcttcag gatataacta ttaggttagt gcaaaagtaa ttgcggtttt     6720

tgccattaaa agtaatggca cattactttt gcaccaaccg acctaatatg actttctttt     6780

agtgttctta ggatttttaa ttgtaaaaca tgtaacaaat tttcctaaac aattgtgcaa     6840

ttcagtggca ttatttacga tgttacgcaa ccactattgt atttccaaaa tgtcatcacc     6900

ctaaacagaa gccctgtaac attgtcaatt aacttctcct tcccttcccc tcagcctttg     6960

gtactgtttc tgcctcaatg catttgtcta agtttagttc atataagtga aattatacaa     7020

tacttgtcct tttttatctg gcttatttca tttagcatgt tttaaaggtt catccatgta     7080

tcaaacagta aagtgcttca tatttggggg aagtataaaa ag                        7122


<210> 2460
<211> 4921
<212> DNA
<213> Homo sapiens

<400> 2460
attccgactt tcccgccccg tacgtgaggg gccgccttga agcctcttcc gccacggaca       60

ctcgaaactg atcttgaagc ccctgccgtc acggatacta gaaactgatc tcgaagcccc      120

ttccgccacg gacactcgaa actctccccc actgttagac ctcagcagcc agcagcccgc      180

cgcccggcgc tgcagctccc tgcccgcagg agccacgtct cgcgcgactc cccccacctc      240

tcgcgacact tgccgcccgt gccctgcggc cctgcacgcc ccacccgcgg tcgcgcgccg      300

cgctccccgc cgcctcacct tttcgcctgg catccgggcc cgctactcgc ccactgggag      360

cgccgtggcg cctggtgttc ggcgcgagcc cggcggggct gcaggttccg ccctgctccg      420

ccgcgccccg cccgggctgg ggtaaaggcc gcggccgggc catgcagtgt cctcctcagg      480

gagggcagga gagcctgagg agtggcgggg ccgccagaga gcgaaatgtc atcagtgcag      540

tcacaacagg agcagttgtc ccagtcagat ccatctccgt caccaaactc atgtagttcc      600

tttgagctaa tagacatgga tgctggcagc ttgtatgaac cagtttctcc ccattggttt      660

tattgtaaga taatagattc taaggagaca tggattcctt tcaactctga ggattcacag      720

cagctggaag aggcatatag ctctggaaaa ggttgtaatg ggagagttgt tcctactgat      780

gggggcagat atgatgttca tttgggggag aggatgcggt atgctgtata ctgggatgaa      840

ctggcatcgg aagtgagacg atgtacgtgg ttttacaagg gggacaaaga caataagtat      900

gttccctact cggagagctt cagccaagtt ttagaggaaa cttacatgct tgctgtaact      960

ttggatgaat ggaaaaagaa actggaatct cccaacagag aaattattat tttacacaat     1020

ccaaagctta tggtgcatta ccagccagtt gcagggtctg atgattgggg ttcaacaccc     1080

acggagcagg gtcgaccaag aactgtgaag agaggagttg agaacatctc tgttgacatt     1140

cattgtggag aacctttaca aatagatcac ttggtttttg tagtccatgg gattggacca     1200

gcttgtgatc tccgctttcg aagcattgta cagtgtgtta atgattttcg cagtgtttcc     1260

ttgaacttgc tacagacaca ttttaagaaa gcccaagaaa atcagcagat tgggagggta     1320

gaatttcttc cagtcaactg gcacagtcct ttgcattcta ctggtgtgga tgtagatctg     1380

cagcgaataa ccctgcccag cattaaccgc ctcaggcact tcaccaatga cacaattctg     1440

gatgtcttct tctacaatag tcccacctac tgtcagacta ttgtggacac agttgcttct     1500

gaaatgaacc gaatatacac actttttcta cagaggaacc ctgatttcaa agggggtgta     1560

tccattgctg gtcatagttt aggttcgctt atattgtttg atatcctaac aaatcagaaa     1620

gattctttgg gggatattga cagtgaaaag gattcgctaa atattgtaat ggatcaagga     1680

gatacaccta cactagagga agatttgaag aaacttcagc tctctgaatt ctttgatatc     1740

tttgagaagg agaaagtaga taaggaagct ctggctttat gtacagaccg agatcttcag     1800

gaaataggaa ttcctttagg accaagaaag aagatattaa actatttcag caccagaaaa     1860

aactcaatgg gtattaagag accagccccg cagcctgctt caggggcaaa catccccaaa     1920

gaatctgagt tctgcagtag cagtaatact agaaatggtg actatctgga tgttggcatt     1980

gggcaggtgt ctgtgaaata cccccggctc atctataaac cagagatatt ctttgccttt     2040

ggatctccca ttggaatgtt ccttactgtc cgaggactaa aaagaattga tcccaactac     2100

agatttccaa cgtgcaaagg tttcttcaat atttatcacc cttttgatcc tgtggcctat     2160

aggattgaac caatggtggt cccaggagtg gaatttgagc caatgctgat cccacatcat     2220

aaaggcagga agcggatgca cttagaactg agagagggct tgaccaggat gagtatggac     2280

cttaagaaca acttgctagg ttcgctgcgg atggcctgga agtcttttac cagagctcca     2340

taccctgcct tacaagcttc agaaacacca gaagaaactg aagcagaacc tgaatcaact     2400

tcagagaagc ctagtgatgt taacacagaa gagacctctg tggcagttaa agaagaagtc     2460

ctgcctatca atgtggggat gctgaatgga ggccaacgca ttgactatgt gctacaggag     2520

aagcctattg aaagttttaa tgagtattta tttgctttac aaagccatct atgctactgg     2580

gagtctgaag atacagtatt gctcgtcctc aaagagatct accaaaccca gggtatcttc     2640

cttgatcagc ctttacagta aaaatgaccc atctatggct gcttaatacg gacattgagg     2700

gatccttccc cagaaaatcc acctgtttgt tgctgcaatt ttcctctcct cagctgcgtc     2760

atttcctgca tgttgcctgc cacttactca ccactggggt ctttggaaga taatcttcct     2820

ctttggaaat gaatggaaaa gcaaaaggcc ctattacttt taaccactgg cttcatataa     2880

acacttgcca tttttttctg catagctggg ggtggtttgt gtctttaatt ctttgatgat     2940

agtttatagt tgccacactt tattgattag tacttgacag ggtgtaaagc ctattttggg     3000

tttgatttgt tttgggtggg gtagacatgt ttttaaggaa cttattgctt atctttagaa     3060

aatgttctag tttggaaaca gattcttgag attcagaagg cattttggag tacacttatc     3120

tcttgtttgt gttgaactga aggctaagtc tcagtggaca tggaaaagac ttttgggtga     3180

tttatttttg aacctgcatt tctttcttat gtgtagtgta tgaagaaaga ctagaatgta     3240

gctttaaaaa agtgttgttt actctcttag aactgacaga cttattgcca gaaatcactg     3300

atgttcattg tttttgcaac tgtttgagct gctgtaagag tctaaagttg acaagttagt     3360

tcatgttagg tgcatcttta taaagcaaag atgttgtata tcctaggcct cccttttata     3420

tttgatagaa gttatttgct aatagcttct attcttacgt tgaaaatagt tgtaaaagct     3480

gatgaacctg aaattgtgta gcctctacag gctgctgagg ttctaaataa aaccttttag     3540

tggtgccttt atggtgaaac agaatttgtc acctgccatt tctacttgag ctaaggtagt     3600

attgtgtatc ctctttcctt cttaggtatc cataatccac aaagcatatt taaaaggctc     3660

ttggcacggg cagcattggt tgagcaggta ggtttggcta gggggaaatg tttaacttgt     3720

tctgaaagaa aaacttatgt ctgtagggtc caagaaacag ctattccaga gtcagtgtca     3780

gctgagtctg gaacatatga agtgaggttt acttctaaga acacaagtga ctgcacacta     3840

attttgtcaa ggcatctttt cactactttg ctgtagattt ttcttcttca ttggtcagtt     3900

tgtcattgtc tttgtagttc tctttatgat aatcctttat acttgctctc agattccaca     3960

ggcctctgtt tatagagtgg caaaggcagg cgagctgtgg tttattgttt ataaattttt     4020

ttataaatgt tatggtattc aaagccactg acatttaata tttactgaag ccattcctta     4080

gacagcagtg gtctttatcc ctttctggaa agaaaaggaa aatgaagggt aattactgtc     4140

accatggaga ttgtagaggt aaggttgggg tataggtcag gcctggcctt tctttgtcat     4200

ctgcttatag tctagtgcta agtatgccac taagtttcag atatatggaa tactttattt     4260

ttttaaaggt atataaactc tgagttattg agaattaagt attcactgta tattaagggg     4320

aagcttttgc caagttgtgg tcttcaaatt tatgtttact cttcctattg gcagaatagg     4380

tgctatttaa gagtaaacca aaggataagc agagggagtc cctataacca aagatggaca     4440

gcatagccct ggatagccag ataaaccact ctttgtatta agaaatgttt ctttcctagt     4500

ggtgaggggt gggtaactgt gaaagagctt tatatcttgt ctattcatgg tattatagct     4560

gtatattccc aggatgataa gcttgattga aatcctgtat ttagtcatat attatttgcg     4620

ctgcttcatt tgtatcatgt gcaatctcta gaccaaccct atttttaaac tctggtacag     4680

catcattttg tacatattcc cagctgcaga actagtatca cttatctcag caaaagagat     4740

tgtttgcatg gaaagattaa tagcactgat tagatttcta atattttgca tttttgaaat     4800

gtttgttttc tacgtgatta tatttaaaac tttagtaaat actaacatga aaccatattg     4860

actagtggcc tacttttacc tggactcacc cgtctcaaag tcaagaaaat cagtacagtc     4920

a                                                                     4921


<210> 2461
<211> 9451
<212> DNA
<213> Homo sapiens

<400> 2461
gtgctgtggc ggcggcggcg gcggtagtgg cggcggcggc ggtgcctggg cggcagcagc       60

agcagtagcg gcagccctga ggacggtgag acggccgcgg cggcggcgac agcgcggaag      120

tcgcgcggga cccagagctt cccccctgtc gctagtgctg aggctttcgc ctttcctacc      180

cagcttcttg ctcacggccc gggctgggct gggcagggca acgcgccccc ggggaggggc      240

ggagctgtag atatggtgta agatacttct tcaagattgg acagctgggg accttcttct      300

gattaacctt aaaccaactt gtagccatag agacacctca caaggttccc atttttgttg      360

ttgttgttgt tgattttctg ctcacacctt tcctgacctt gcaaccatgt atggaagtgc      420

ccgctctgtt gggaaggtgg agccgagcag ccagagccct gggcgttcac ccaggcttcc      480

acgttcccct cgcttgggtc accgtcgaac caacagtacg ggagggagtt cgggaagcag      540

tgttggaggt ggcagtggga aaaccctttc aatggaaaat atacaatctt taaatgctgc      600

ctatgccacc tctggcccta tgtatctaag tgaccatgaa aatgtgggtt cagaaacacc      660

taaaagcacc atgacacttg gccgttctgg gggacgtctg ccttacggtg ttcggatgac      720

tgctatgggt agtagcccca atatagctag cagtggggtt gctagtgaca ccatagcatt      780

tggagagcat cacctccctc ctgtgagtat ggcatccact gtacctcact cccttcgtca      840

ggcgagagat aacacaatca tggatctgca gacacagctg aaggaagtat taagagaaaa      900

tgatctcttg cggaaggatg tggaagtaaa ggagagcaaa ttgagttctt caatgaatag      960

catcaagacc ttctggagcc cagagctgaa gaaggaacga gccctgagaa aagatgaagc     1020

ttccaaaatc accatttgga aggaacagta cagagttgta caggaggaaa accagcacat     1080

gcagatgaca atccaggctc tccaggatga attgcggatc cagagggacc tgaatcagct     1140

gtttcagcag gatagtagca gcaggactgg cgaaccttgt gtagcagagc tgacagagga     1200

gaactttcag aggcttcatg ctgagcatga gcggcaggcc aaagagctgt ttcttcttcg     1260

aaagacattg gaggaaatgg agctgcgtat tgagactcaa aagcagaccc taaatgctcg     1320

ggatgaatcc attaagaagc ttctggaaat gttgcagagc aaaggacttt ctgccaaggc     1380

taccgaggaa gaccatgaga gaacaagacg actggcagag gcagagatgc acgttcatca     1440

cctagaaagc cttttggagc agaaggaaaa agagaacagt atgttgagag aggagatgca     1500

tcgaaggttt gagaatgctc ctgattctgc caaaacaaaa gctctgcaaa ctgttattga     1560

gatgaaggat tcaaaaattt cctctatgga gcgtgggctt cgagacctgg aagaggaaat     1620

tcagatgctg aaatcgaatg gtgctttgag tactgaggaa agggaagaag aaatgaagca     1680

aatggaagtg tatcggagcc attctaaatt tatgaaaaat aaggtagaac aactgaagga     1740

ggaactaagt tcgaaagagg ctcaatggga ggagctgaaa aagaaagcgg ctggtcttca     1800

ggctgagatt ggccaggtga aacaggagct gtccagaaag gacacagaac tactcgccct     1860

gcagacaaag ctagaaacac tcacaaacca gttctcagat agtaaacagc acattgaagt     1920

gttgaaggag tccttgactg ctaaggagca gagggctgcc atcctgcaga ctgaggtgga     1980

tgctctccga ttgcgtttgg aagagaagga aaccatgttg aataaaaaga caaaacaaat     2040

tcaggatatg gctgaagaga aggggacaca agctggagag atacatgacc tcaaggacat     2100

gttggatgtg aaggagcgga aggttaatgt tcttcagaag aagattgaaa atcttcaaga     2160

gcagcttaga gacaaggaaa agcagatgag cagcttgaaa gaacgggtca aatccttgca     2220

ggctgacacc accaacactg acactgcctt gacaactttg gaggaggccc ttgcagagaa     2280

agagcggaca attgaacgct taaaggagca gagggacaga gatgagcgag agaagcaaga     2340

ggaaattgat aactacaaaa aagatcttaa agacttgaag gaaaaagtca gcctgttgca     2400

aggcgacctt tcagagaaag aggcttcact tttggatctg aaagagcatg cttcttctct     2460

ggcatcctca ggactgaaaa aggactcacg gcttaagaca ctagagattg ctttggagca     2520

gaagaaggag gagtgtctga aaatggaatc acaattgaaa aaggcacatg aggcagcatt     2580

ggaagccaga gccagtccag agatgagtga ccgaatacag cacttggaga gagagatcac     2640

caggtacaaa gatgaatcta gcaaggccca ggcagaagtt gatcgactct tagaaatctt     2700

gaaggaggtg gaaaatgaga agaatgacaa agataagaag atagctgagt tggaaaggca     2760

agtgaaagac cagaataaga aggtagcaaa tctgaagcac aaggaacagg tggaaaaaaa     2820

gaagagtgca caaatgttag aggaggcgcg acgacgggag gacaatctca acgacagctc     2880

tcagcagcta caggacagtc tccgtaagaa ggatgacagg attgaagagc tggaagaagc     2940

actaagagaa agtgtacaga taactgcaga gcgggaaatg gtgctagcac aagaggaatc     3000

agccaggacc aatgctgaaa aacaggtgga ggagttactg atggccatgg agaaggtaaa     3060

gcaggaacta gaatccatga aagcaaagct gtcctccacc cagcagtctc tggcagaaaa     3120

ggaaactcac ttgactaatc ttcgggcaga gagaaggaaa cacttagagg aagttctgga     3180

gatgaagcaa gaagctcttc tggctgccat tagtgaaaaa gacgccaata tagctctctt     3240

ggagctttcg tcctctaaga agaagaccca agaggaagtg gctgccctga agcgggagaa     3300

ggatcgtctg gtacagcagc ttaagcagca gacgcaaaat cgaatgaagc taatggccga     3360

caactacgag gatgaccact tcaaatcctc ccattccaat caaacaaatc acaagccctc     3420

cccagaccag atcatccagc ccctcttaga acttgaccaa aatagaagta aattaaagtt     3480

gtacattgga cacctgacaa ccctctgcca tgaccgagac cccctgatcc tccgtggact     3540

cactccacca gcttcctata acttggacga tgaccaggcg gcttgggaga atgagctgca     3600

gaagatgacc cgggggcagc ttcaggatga gttagagaaa ggtgaacggg acaatgcaga     3660

actgcaggag tttgccaacg ccattcttca gcagatagca gaccattgtc ccgacatcct     3720

agagcaagtg gtcaacgccc tggaagagtc ctcttgaccc tgctttatgg ggaagcctga     3780

ggtagtcaac ccaggagcca agaaaagaga actacgagga acaggtgccc ggaaccttct     3840

tggcaccaaa cactacaaac ttcatcccaa cttgctcact tgaagaagtg tgattccagc     3900

accgtttcta catctgccat cttactctgc ctttctgctt tggatgtggt ctctacacta     3960

accttcttga tgtccagggt agataaaggg tcgaatctct ctgaagaact gccacctggt     4020

catcagcagt ggagaactgt gggagctggt ggctctgccc tgacagagag ccatggagca     4080

gaggagcctc tcacctcctg tcctctgaca tgagaatgaa accaggaatg gacttggagt     4140

tcaacaggct gagaggatgc ctccaatgga ccagagagct gagtgttcta atatcacaat     4200

aggtgctttc tcctaaaagg gcaaaaaaca atctcaaaaa gattagaaaa agagaagggg     4260

ggaagggaag agaaaatcga ctcttctttt tactgtctct tctgcttact ttccacatga     4320

gatgctttgt accggggagc tgtgagcagg cctcacgatg gcttgggagc actcgttctc     4380

ccaaggtctg agtcttcatc cagccctgcc tgtctgtcgc agccttcctc actctgttcc     4440

tcggccagtt aacaagaaga tggtgtgagg tgttctccac cagtctctcc tgtttgagac     4500

tgttgacgtt atcatactga ggtgttagat caaatatctc taattgaaga acatgtgagg     4560

ttgaaagagc accagccagg gcaacatagc gtgaccctgt ctctacaaaa aattaaaaag     4620

agaacataca aagttgacat atgagaccct gttgtccccg cctgcagctt tgccccagta     4680

acagatgccc gttgctcttg ggctggtttc ccctgaacac ctccaagagg ctgcctgcct     4740

tgccagcacc cgtgtcctga gctcctgcag cccagtggct gctgaagttg tgatccctca     4800

ctcaccctgc tagctttgcc cttgactcgt cttctctgaa cctcagcctc gtgcattgcc     4860

tggaaccttc ttctagcata aatgaaggtt tttcctccta cacacattcc ttcctcggtt     4920

atttcattca gagaatattt atgaaatgcc tactgtgtgc aagtcatcca tccttgaaaa     4980

ggccacttct cagtgaggga gagatgtagt ggattctgtg agacatacct gctggagttg     5040

aagcagtaaa tagcatgtcc ttcccctccc cgatcttaag gtgtgttttc tagaaaagtt     5100

ccctaatgga attcatgagt ttgggggtct cagtcacccg cttgcctgta ggattccatt     5160

tgatgattct ggatttttgc tgtttgttat tgcccttaga ggggctctga gtatctactt     5220

gtgggtggcc atttcctgac atctgcatgt acctcgtgga attcagccag cttcatgttg     5280

caaatcagaa agctgacccc aagactgcaa atcaatgaag gtattggcat tgttaaggac     5340

gtagcgtaga caacagcagt cataaataat taggcaggaa cttaacccaa atctagttct     5400

ttgaccacct ctaccaccag aacccagcag acactcacat ctcctgataa gagttgctgg     5460

actcgatgtt tttgttttgc attttctcct ctccttcccc acttactcag agaatttaaa     5520

gtctgtagag tcagcacagc cccatcagtc caggaacttc ccaccaccag cccttgactg     5580

tcccattaac tgacatggtc agatttccag ctccccctac tccctgctgt gaaacaatcc     5640

ctctccctgt gagaggaaac tgtggagcgt ttcttatcga aggttaaatg gactctgctc     5700

ataaacctct tactgagatg cttcctgata gccaggctgg ccagagaggg gtgcaggggt     5760

tagatagtaa gtggtggtcg tttgtggtca gttacctcaa ttctgttcat tgcagtgccc     5820

gtaaaccatg tagaaagctc ccagcactga aaggcaggag tgttagcatc tcgctttatc     5880

caccataacg taaagaactg cggtgtgata acagccttca cggggccacg gtggaaccaa     5940

gacagcaggc gaggccatgc ctaaacaagt ggtctggcac gggcactggc cagctgctct     6000

ctccaagcag gtggcccaga tcccacccac gtggactttc tcatcaggtg cagcgcctgc     6060

cactctcagc cactgggtgt gtcactctcc tcttcatctc agcattctcc atcacttccc     6120

ctccagaaaa acggatggaa ggaagccctc tgtgacactg cttctgagaa gaagcatttc     6180

cgggaccgat atcatctgtc tggtctctgt gaacagcaag gaatcttctt gaccgttctt     6240

gggcactgga ggctggctag gagttcagta ataaacgtgg ccttcgtgct gtagggcaga     6300

gtggatgcag tttgtagctt tcagagtgtc tcattgagtc tagatcattg aaccaacact     6360

taaccaaatg tcccactccc atcacactag gacttgtcat tccatgcccc tctcctagtg     6420

gtcatggttt catatgggca tacaactgct actgaagtta tatagccttg aaaactcagt     6480

gcaggttgcc cttaattttc cccaaacccc tccatcggca agtctagttg ccctttagca     6540

cctaaagatc tgcaccccaa accaatgtca ccataaagag ggcacgaaga agagtgggtg     6600

tgatcccaac ggggttttgt aactgaagaa gcccagtgtg agcttctcat cttttcatat     6660

acctctaacc cccggtactc attgaatcat tgatgaggta tctcaattga gatttgcaag     6720

gactttgata ccatttgaaa tggaaaaatt ttgaacgggc tttaacatgt ttaagaaata     6780

tggatggggc cggccacagt ggctcacgcc tgtaatccca gaactctgga aggctgaggc     6840

aggcggatca cctgagatca ggagttcgag gccagcctgg ccaagatggc aaaaaccccg     6900

actctactaa aaatacaaaa ttagccaggc gtggtggcgt acgcctgtaa tcccagctac     6960

tcaggaggca ggagaatcgc ttgagcctgg gaggcagagg ctgcggtgag ccgagatcgt     7020

gtcactgcac tccagcctgg gtgacagaga ctccatttaa aaaaaaaaaa aaaaaatata     7080

tatatatata tatatatata tatatggatg ggaatcacca aattcatctc agctctaacc     7140

ttttaacctt tgtccttgca ctttacaatc taaagatcta cctgtggctc tcagacttcc     7200

tcacacttgg gttttagaaa taacttgtaa agcagactgg acccaaggcc gccttcagtg     7260

tcaagaaggg cattgtgact tgcccctcaa tttctgtcca ttgaagtctg gttttccatg     7320

aggaacttgc gggctcaccc acccccagag tgagagaaga ggaaggcgaa gtcatcacag     7380

acacggtctt agccacctgc tgaactaatc cctccgctat tgagggtcag ggttgtgagg     7440

caaccatcat gtgtcacccc aaaatataaa tgtttctgag ccgcccatcc actggcattt     7500

ggatttgctg ccagagtcct gttcctccca gaaccatccc gccctcctgt tgaccatgtt     7560

acttgagtgt aggcccggtg tcaagaccct cagagtcttt gaggaaagag ccaagcagag     7620

aagaccgctg cgtggagtgt gacaccacat ggcatttctc aagcccagcg gaccctgtgt     7680

cagcaaatac cagtaattta acatctgctc ctggcctcct cttcacctgc ctgggttcgg     7740

aactgaggag gaaggatgag aagagactgc aatgcagcag gcaccctctg cagagtgagg     7800

ccgcccgtcc atcactgcca gccctgggct gctcaggagg ggacgtgaac cactcaaagg     7860

aatgtcttaa agaggatctg gagtttcccc catgcaaatt agggaagaat taggcaagaa     7920

aagacataca ttacagggaa atccttctga acaaaatggc tgtcttcacc tactcttctt     7980

gcaagaaaag acatacatta cagggaaatc cttctgaaca aaatggctat cttcacctac     8040

tcttcagcaa aaaccgtctc cagacttttt agtgtcaaaa atgtaaccaa ctgtctcctg     8100

attttttcca atgtgtttgg caagtgctgt ggccctgttg taggtacttc tcctgactct     8160

tgggggagaa gtggttttag ggattgattt gggggagcgg gtttttgtcc catcccacct     8220

cctctcttct ttctctgctt gtcgatattg tctgtgtgat tcagagaatt ggggcagtta     8280

cattgtgtct gttgttgaga ttattaaaag attaaaacgt agttgtagaa atgaaaaatt     8340

aaacagctgt gttttaaaaa tgcaaaccaa tatcttgtta ataaaggaat tcaagctatg     8400

gggcagccac actcccctcc tcccaggctg gcataggtgg ccctgggctg gcggcttagg     8460

aagcatggag cacacttagg gtagtgcctg cctgggcaag agacacctgc cgagcaaaag     8520

gaacgagaat ctggggctca gagcctcgca gttgtgccag gattttccta tacatgttca     8580

ggacctctgg gtagaggttt cacagtttgt gaccccataa ccaccctcac ccgacgtggg     8640

ttctagctca gtgtgcctaa tactgcatgg taacctgggc ttgaccctga agcccctgcc     8700

tggcaggcca caggacctct cctgcccact tggtgctatc tcttccagtg accacccagc     8760

acgggtgagc actggccagc ctggagcctg caatccaggt ggaacagact gtcctccatg     8820

tcagttcctt ctggcttcag gccctcaatt atttcccttt gagctttttt agaccctaga     8880

tctcctaggc ccaggctctc tcttgacccc agagaagcca ctgtcaggaa aggaagtgaa     8940

ccctactgaa gccagagaat tcaccccggc caaagcaggc cctctgggtc cagcccctca     9000

ttccacacca cgccagtatt gcatccatct actgcagcta cacatcctga gggcagcacc     9060

acccactctg gcctgctggc ccatcgcagg actagcccag gcacctgccg ggcattgcag     9120

gatatccagt ggggcctgtg actgctccct gatgcgtcag aagagaagtg ttgcacttta     9180

gtggaggagc tgaggagcac ctgccccctt gtagcttgag ttccttttgg taacagtagc     9240

agcctccatg gtggtgtctg ggatgcacgt gcacccgctg ccttcagctg tatgtgtgtg     9300

ttcctgctgg agttgtgtta ctgacaggat aatgacatta caaagaaatt gtgttatatt     9360

caactttgcc ttgataatta ttgtaaacac tttgttcatt ttttcttttt tattcacaaa     9420

ctaaatccac caggaaatta taaagttatt t                                    9451


<210> 2462
<211> 3061
<212> DNA
<213> Homo sapiens

<400> 2462
gccatgaact tccaggcggg cggggggcag agcccgcagc agcagcagag cctggcggct       60

ccggggggcg gcggcgctgc cgcgcagcag ctcgtctgcg gcgggcagtt cggcggcgcg      120

gggcccgggg ccgggggcgg cggcggcccc tcgcagcagc tggccggcgg gcccccccag      180

cagttcgcgc tctccaactc cgcggccatc cgggccgaga tccagcgctt cgagtccgtg      240

catcccaata tctacgccat ctacgacctg atcgagcgca tcgaggattt ggcgctgcag      300

aaccagatcc gggagcacgt catctccatc gaggactcgt ttgtgaacag ccaggagtgg      360

acgctgagcc gctccgtacc ggagcttaaa gtgggcatag tggggaacct gtctagcggg      420

aagtcagccc tggtgcaccg ctatctgacg gggacctatg tccaggagga gtcccctgaa      480

ggggggcggt ttaagaagga gattgtggtg gatggccaga gttacctgct gctgatccga      540

gatgaaggag gcccccctga gctccagttt gctgcctggg tggatgcagt ggtgtttgtg      600

ttcagcctgg aggatgaaat cagtttccag acggtgtaca actacttcct gcgtctctgc      660

agcttccgca acgccagcga ggtgcccatg gtgcttgtgg gcacgcagga tgccatcagc      720

gctgcgaatc cccgggttat cgacgacagc agagcccgca agctctccac agatctgaag      780

cggtgcacct actatgagac gtgcgcgacc tacgggctca atgtggagcg tgtcttccag      840

gacgtggccc agaaggtagt ggccttgcga aagaagcagc aactggccat cgggccctgc      900

aagtcactgc ccaactcgcc cagccactcg gccgtgtccg ccgcctccat cccggccgtg      960

cacatcaacc aggccacgaa tggcggcggc agcgccttca gcgactactc gtcctcagtc     1020

ccctccaccc ccagcatcag ccagcgggag ctgcgcatcg agaccatcgc tgcctcctcc     1080

acccccacac ccatccgaaa gcagtccaag cggcgctcca acatcttcac gtctcggaag     1140

ggtgctgacc tggaccggga gaagaaggct gccgagtgca aggtggacag catcgggagc     1200

ggccgcgcca tccccatcaa gcaggggatc ctgctaaagc ggagcggcaa gtccctgaac     1260

aaggagtgga agaagaagta tgtgacgctc tgtgacaacg ggctgctcac ctatcacccc     1320

agcctgcatg attacatgca gaacatccac ggcaaggaga ttgacctgct gcggacaacg     1380

gtgaaagtgc cagggaagcg cctgccccga gccacacctg ccacagcccc gggcaccagc     1440

ccccgtgcca acgggctgtc cgtggagcgg agtaacacac agctgggtgg gggcacagcc     1500

agtggcccag ctgaggtact cagttccagc cccaagctgg atcctccccc atctccccac     1560

tccaaccgga agaagcaccg gaggaaaaag agcaccggga ccccccgacc agacggcccc     1620

agcagtgcta ctgaagaggc agaggagtcg tttgaatttg tggtggtgtc cctcactggg     1680

cagacgtggc acttcgaggc ttcaacggcg gaggagcggg agctgtgggt tcagagtgtg     1740

caggcccaga tccttgccag cctgcaaggc tgccgcagtg ccaaggacaa gactcgactg     1800

gggaaccaga acgcagctct ggctgtgcag gccgtccgca ccgtccgcgg caacagcttt     1860

tgtatcgact gcgatgcacc caatccagac tgggccagcc tgaacctggg tgccctgatg     1920

tgcattgagt gctcaggcat ccaccgacac ctgggggctc acctgtcccg ggtgcgctcc     1980

cttgacctcg atgactggcc gcctgagctg ctggctgtca tgactgccat gggcaatgcc     2040

ctcgccaaca gcgtctggga gggggccttg ggtggctact ccaagccagg gcctgatgcc     2100

tgcagagagg agaaggaacg ctggatacgg gccaagtatg aacagaagct cttcctggcc     2160

ccactgccaa gctcagatgt gccactgggg cagcagctgc tccgggccgt ggtggaagat     2220

gacctgcggc tgttggtgat gctcctggca catggctcca aagaggaggt gaatgagacc     2280

tatggggacg gggacgggcg gacggctcta catctctcca gtgccatggc caacgttgtc     2340

ttcacgcagc tgctcatctg gtacggggtg gacgtgagga gccgggacgc ccggggcctg     2400

actccactgg catatgctcg ccgggccggc agccaggagt gtgcagacat cttgatccag     2460

catggctgcc ctggggaggg ctgtggctta gcgcctaccc ccaacagaga gcctgccaat     2520

ggcaccaacc cctctgctga gctgcaccgt agtcctagcc tcctataagg cccaggaaga     2580

gggcagaggg gccagaagga ctccatggcc caaagaccct cctccctgca ggcactgtgg     2640

gaacagacac agagatggag aagcagggac atgctgagag gacgaagcca aggaaattag     2700

ggaggagagt caaagggatc aaggagagtt ggggatttga gctgcagcag agagggatga     2760

gggatttagc cctctgccct aaggtgccat tgaaaaggga caggaccctt cggaggtgcc     2820

tgtgaggaga ggggagcagg acctctccct cctccagatc cctgcctcct agtgccagcc     2880

cctcacacgc cttcatcctg aaacaggaag aggacggcac caagttgggg gtgctggatg     2940

aaagagacga ggggtgatct gtgagtccca tgtaaacttt gtacattgga atatttatgt     3000

ttgtgtacat atttgatgtg tgtgtgtatg atgagccaat aaaccagact gtgtgcgtgg     3060

c                                                                     3061


<210> 2463
<211> 681
<212> DNA
<213> Homo sapiens

<400> 2463
gttgctagcc ggggccagcg gcggtggcgg cggcggcgga ggcgtcggtg gaggagggga       60

ggcggcgagg aggcgcagct cccgctgcac cgcgatcgac gctgcggagc gagcccaccc      120

gccccgggag ctcgcctccc cggtgctccc ccgccctccc cgccccccca gcggcgctgc      180

ctcctccaaa tgagcgattc gcccgctgga tctaacccaa ggacacccga aagcagcggc      240

agcggcagcg gcggcggcgg gaagaggccg gcggtgccgg cagcggtgtc cctcttgcca      300

ccggcggacc ccctgcgcca ggcgaaccgg ctcccgatca gggtcctgaa gatgctgagc      360

gctcacaccg gtcacctcct gcacccggag tacctgcagc cgctgtcctc cactcccgtc      420

agccccattg agctggacgc caagaagagc cccttggcgc tgctggctca gacctgctcg      480

cagatcggca gccccgggtc gctgtccttg cggaatccac acactttggg cctaagccgg      540

taccacccct atggcaagag ccacttatcc acagcggggg gcctggccgt gccgtccctc      600

cccacagccg gaccctacta ttcgccatac gcgctgtatg gacagagact agcttcagcc      660

tcggcgctgg gataccagta a                                                681


<210> 2464
<211> 3225
<212> DNA
<213> Homo sapiens

<400> 2464
atgaacttcc aggcgggcgg ggggcagagc ccgcagcagc agcagagcct ggcggctccg       60

gggggcggcg gcgctgccgc gcagcagctc gtctgcggcg ggcagttcgg cggcgcgggg      120

cccggggccg ggggcggcgg cggcccctcg cagcagctgg ccggcgggcc cccccagcag      180

ttcgcgctct ccaactccgc ggccatccgg gccgagatcc agcgcttcga gtccgtgcat      240

cccaatatct acgccatcta cgacctgatc gagcgcatcg aggatttggc gctgcagaac      300

cagatccggg agcacgtcat ctccatcgag gactcgtttg tgaacagcca ggagtggacg      360

ctgagccgct ccgtaccgga gcttaaagtg ggcatagtgg ggaacctgtc tagcgggaag      420

tcagccctgg tgcaccgcta tctgacgggg acctatgtcc aggaggagtc ccctgaaggg      480

gggcggttta agaaggagat tgtggtggat ggccagagtt acctgctgct gatccgagat      540

gaaggaggcc cccctgagct ccagtttgct gcctgggtgg atgcagtggt gtttgtgttc      600

agcctggagg atgaaatcag tttccagacg gtgtacaact acttcctgcg tctctgcagc      660

ttccgcaacg ccagcgaggt gcccatggtg cttgtgggca cgcaggatgc catcagcgct      720

gcgaatcccc gggttatcga cgacagcaga gcccgcaagc tctccacaga tctgaagcgg      780

tgcacctact atgagacgtg cgcgacctac gggctcaatg tggagcgtgt cttccaggac      840

gtggcccaga aggtagtggc cttgcgaaag aagcagcaac tggccatcgg gccctgcaag      900

tcactgccca actcgcccag ccactcggcc gtgtccgccg cctccatccc ggccgtgcac      960

atcaaccagg ccacgaatgg cggcggcagc gccttcagcg actactcgtc ctcagtcccc     1020

tccaccccca gcatcagcca gcgggagctg cgcatcgaga ccatcgctgc ctcctccacc     1080

cccacaccca tccgaaagca gtccaagcgg cgctccaaca tcttcacgtc tcggaagggt     1140

gctgacctgg accgggagaa gaaggctgcc gagtgcaagg tggacagcat cgggagcggc     1200

cgcgccatcc ccatcaagca ggggatcctg ctaaagcgga gcggcaagtc cctgaacaag     1260

gagtggaaga agaagtatgt gacgctctgt gacaacgggc tgctcaccta tcaccccagc     1320

ctgcatgatt acatgcagaa catccacggc aaggagattg acctgctgcg gacaacggtg     1380

aaagtgccag ggaagcgcct gccccgagcc acacctgcca cagccccggg caccagcccc     1440

cgtgccaacg ggctgtccgt ggagcggagt aacacacagc tgggtggggg cacaggtgcc     1500

ccccactcgg ccagcagcgc atccctgcac tctgagcgcc ccctcagcag ctcggcctgg     1560

gctggcccgc gccctgaggg gctgcaccag cgctcctgct ccgtttccag cgccgaccag     1620

tggagtgagg ccaccacttc cctgccccca ggcatgcagc accctgccag tggcccagct     1680

gaggtactca gttccagccc caagctggat cctcccccat ctccccactc caaccggaag     1740

aagcaccgga ggaaaaagag caccgggacc ccccgaccag acggccccag cagtgctact     1800

gaagaggcag aggagtcgtt tgaatttgtg gtggtgtccc tcactgggca gacgtggcac     1860

ttcgaggctt caacggcgga ggagcgggag ctgtgggttc agagtgtgca ggcccagatc     1920

cttgccagcc tgcaaggctg ccgcagtgcc aaggacaaga ctcgactggg gaaccagaac     1980

gcagctctgg ctgtgcaggc cgtccgcacc gtccgcggca acagcttttg tatcgactgc     2040

gatgcaccca atccagactg ggccagcctg aacctgggtg ccctgatgtg cattgagtgc     2100

tcaggcatcc accgacacct gggggctcac ctgtcccggg tgcgctccct tgacctcgat     2160

gactggccgc ctgagctgct ggctgtcatg actgccatgg gcaatgccct cgccaacagc     2220

gtctgggagg gggccttggg tggctactcc aagccagggc ctgatgcctg cagagaggag     2280

aaggaacgct ggatacgggc caagtatgaa cagaagctct tcctggcccc actgccaagc     2340

tcagatgtgc cactggggca gcagctgctc cgggccgtgg tggaagatga cctgcggctg     2400

ttggtgatgc tcctggcaca tggctccaaa gaggaggtga atgagaccta tggggacggg     2460

gacgggcgga cggctctaca tctctccagt gccatggcca acgttgtctt cacgcagctg     2520

ctcatctggt acggggtgga cgtgaggagc cgggacgccc ggggcctgac tccactggca     2580

tatgctcgcc gggccggcag ccaggagtgt gcagacatct tgatccagca tggctgccct     2640

ggggagggct gtggcttagc gcctaccccc aacagagagc ctgccaatgg caccaacccc     2700

tctgctgagc tgcaccgtag tcctagcctc ctataaggcc caggaagagg gcagaggggc     2760

cagaaggact ccatggccca aagaccctcc tccctgcagg cactgtggga acagacacag     2820

agatggagaa gcagggacat gctgagagga cgaagccaag gaaattaggg aggagagtca     2880

aagggatcaa ggagagttgg ggatttgagc tgcagcagag agggatgagg gatttagccc     2940

tctgccctaa ggtgccattg aaaagggaca ggacccttcg gaggtgcctg tgaggagagg     3000

ggagcaggac ctctccctcc tccagatccc tgcctcctag tgccagcccc tcacacgcct     3060

tcatcctgaa acaggaagag gacggcacca agttgggggt gctggatgaa agagacgagg     3120

ggtgatctgt gagtcccatg taaactttgt acattggaat atttatgttt gtgtacatat     3180

ttgatgtgtg tgtgtatgat gagccaataa accagactgt gtgcg                     3225


<210> 2465
<211> 3257
<212> DNA
<213> Homo sapiens

<400> 2465
cagtccgagg agggtcacgc aggcggcaga tgccaggcgg gcagccccgc ccctgcgcgc       60

cgcctcagcg gcgccttcaa gacgctggtc ccaggcaccc acgcccaggg cgcctcggat      120

acccaccccc tcggcccccc gcacaccccg gtcctcgacc cctctccgca ggatggtttc      180

ccggtcctct ggcgaggatc ctccaaggcg tctcacatga accggctcag aaacgccaaa      240

atctacgtgg agagagctgt caagcagaag aagatcttta caatccaagg ctgctacccg      300

gtgatccggt gtctcttgcg ccggaggggc tgggtggaga agaagatggt ccatcgctca      360

ggccccaccc tgctgccacc ccagaaggat ctggatagct cagcgatggg tgacagtgac      420

accactgagg atgaggatga agatgaggac gaggagttcc agccatcaca gctgttcgac      480

ttcgatgatt tactgaaatt tgatgaccta gatggaacac atgctctgat ggtgggtcta      540

tgtctcaatc tccggaattt gccgtggttt gatgaggttg atgccaactc cttcttccca      600

cgctgctact gcctgggggc tgaggatgac aaaaaagcct tcatagagga cttctggctg      660

actgctgccc gcaacgttct caagctggtg gtgaagtctg agtggaagtc ataccctatt      720

caggcagtag aggaagaggc ctcaggagac aagcagccca agaaacagga gaaaaaccca      780

gtgttggtgt ccccagagtt tgtggatgaa gctctgtgtg cgtgcgagga gtaccttagc      840

aacttggccc acatggacat cgacaaggac ctggaggccc cgctgtacct cacccccgag      900

ggctggtccc tcttcctcca gcgctactac caagtggtcc acgaaggggc agaactcagg      960

cacctcgaca ctcaggtcca gcgctgtgag gacatcctgc agcagctgca ggccgtggta     1020

ccccagatag acatggaagg ggatcgcaac atctggatcg tgaagccagg agccaagtcc     1080

cgcggacgag gcatcatgtg catggaccac ctggaggaga tgctgaagct ggtgaacggc     1140

aaccccgtgg tgatgaagga cggcaagtgg gtggtgcaga agtatattga gcggcccctc     1200

ctcatctttg gcaccaagtt tgacctcaga cagtggttcc tggtaactga ctggaaccca     1260

cttaccgtgt ggttctaccg cgacagctat atccgctttt ccacgcagcc cttctccctg     1320

aagaacctgg acaactcagt gcacctgtgc aacaactcca tccagaagca cctggagaac     1380

tcatgccatc ggcatccact gcttccgcca gacaacatgt ggtctagcca gaggttccag     1440

gcccacctgc aggagatggg tgccccaaat gcttggtcca ccatcatcgt gcctggcatg     1500

aaggatgctg tgatccacgc acttcagacc tcccaggaca ccgtgcagtg tcggaaggcc     1560

agctttgagc tctatggcgc tgacttcgtg ttcggggagg acttccagcc ctggctgatt     1620

gagatcaacg ccagccccac gatggcaccc tccacagcag tcactgcccg gctctgtgct     1680

ggcgtgcaag ctgacaccct gcgcgtggtc attgaccgga tgctggaccg caactgtgac     1740

acaggagcct ttgagctcat ctataagcag cccgtcacca cttccccagc ctccacacca     1800

aggcccagct gccttctccc catgtactcc gacaccaggg ccaggtcctc agacgacagc     1860

acagcaagct ggtgggcact aaggccctgt cgaccacagg caaggccttg aggactctac     1920

ccacggctaa ggtcttcatt tccctcccac cgaaccttga tttcaaggtg gcacccagca     1980

tcctgaagcc aagaaaggct cctgctctcc tgtgcctccg aggcccccag ctggaagtgc     2040

cttgttgcct ctgccctttg aagtcggaac aattcctagc acctgtcgga aggtcaaggc     2100

caaaggcaaa ttcaaggcca gactgtgaca aacccagggc tgaggcctgc cccatgaaga     2160

ggctgagccc cctgaaaccc ctgccccttg ttggtacatt ccagaggcgc aggggcctgg     2220

gggatatgaa gctagggaag cccctgcttc gattccccac tgcccttgtc ctggatccaa     2280

caccaaataa aaagaaacaa gtgaagtatt tggggcttga ctccattgct gttggagggt     2340

caagagtgga tggggcgagg ccgtgtaccc cagggtccac agcaagagcc tgaggccatc     2400

agcagctcct ccgtgcagcg aggcccagaa ttcccaccta aggacagaca tggggcttcc     2460

tatttaggga ctcccccagc atctccgatc caggggtggg gagcgtgagc cttcacttta     2520

cagatgaaga aactgagtct gaaagaggag gcatggctta cccaagatca cgtggcagtg     2580

agtcgacgca gggacatatt gccagaactg ccgagcactg ggagcccccc aaccccagag     2640

aacaagccaa gctagcagaa tgacacctac cgggcatagg aacgttaatg ccatgagaca     2700

ggggaaggaa ttggccttgc ctaaacctca gcccttctgc agagggcatg ggtctatccc     2760

ttcttcagca aggggccaag gtcacctaaa aatgaaacat ccaataagcc acacccacct     2820

gaagaaaagt gtggcactgc ttagttgtag tgggttgaac tgtggtcccc tgaaaagaga     2880

tgtctacttg gaccctgtga atgtgacctt atgtgggaaa agagtctttg tagctgggta     2940

tggtggctca cacctgttat cccagcactt tgagaggcca aggcaggaga tcgcttgagc     3000

ccgcaagttc aagaccagtc tgggcaacat ggtgaaaccg tttctacaga aaattagctg     3060

ggtgtggtgg cacacacctg tagtcctagc tactcgggag gcctaggtgg gaggattacc     3120

tgagcctggg aagatcaaaa ctgtggtgag ctgtgatcac gccactgcgc tctgagcctg     3180

ggagacagag tgaaacccta aatcaaaaaa aaaaaaaaag gtctttgcag atgtaaataa     3240

atttaagatc ttaaatg                                                    3257


<210> 2466
<211> 1961
<212> DNA
<213> Homo sapiens

<400> 2466
aaggtgggcc tcgagcaaag ccgctagagg tggggtgcgg gtggtcggcc tcaggcgagc       60

cccggggcac agcccggggc gggaggcgga gcttggcggc cgagatctcc gcgctgcagt      120

tagccccgcc gagcgccagg agctgcgggt aggaggggcg agagaaagga tgggggtaca      180

gaaccggaag aaacgaaggg ctcgtccgct tcggcttgtc ctaatttggt gcccaatctg      240

aagctgggct gtaccattgc atacctgggg gaggctgtgg caaaggtgac aagaaggccg      300

aaggcacaaa gggaagctgc acccattcct ggaggagctt aaatagtgac tcgagtgcaa      360

gaatttaaaa ataccgagac agccctaggt ggaaaacttc cggaaggccc aagcgttcgt      420

aagggctctc taccccgctc ggagcataga tggtaccgtc cggaagtccg ggcggagacc      480

gtagctgcgc ttctcgcgaa agggcaggca tcgcggggct ggccacttcc gtacttccgc      540

tttccggccc agccagcgcc cgcgatgact gccactctcc gcccctacct gagtgccgtg      600

cgggccacat tgcaggctgc cctctgcctg gagaacttct cctcccaggt tgtggaacga      660

cacaacaagc cggaagtgga agtcaggagt agcaaagagc tcctgttaca acctgtgacc      720

atcagcagga atgagaagga aaaggttctg attgagggct ccatcaactc tgtccgggtc      780

agcattgctg tgaaacaggc tgatgagatc gagaagattt tgtgccacaa gttcatgcgc      840

ttcatgatga tgcgagcaga gaacttcttt atccttcgaa ggaagcctgt ggaggggtat      900

gatatcagct ttctgatcac caacttccac acagagcaga tgtacaaaca caagttggtg      960

gactttgtga tccacttcat ggaggagatt gacaaggaga tcagtgagat gaagctgtca     1020

gtcaatgccc gtgcccgcat tgtggctgaa gagttcctta agaattttta aaccatctgg     1080

ctggatctcg tggccttccc cctcagacta cccatgtctc cacgaaggcg tcctggagtc     1140

actccccgag cagcgcggcg gcggcaggga gttgggttgg ggtgggcatt tgatgcggga     1200

ggtgggtggt gtgcttgcta gctgggcaag aaagcagcag tggacctgcc ccaaggccac     1260

acgtgcctgg tcaggctggc ttctgatgtt cagtcccctg ggccgggaca gatttttttt     1320

aacgtcttga aacttaaact ctgtgcttgt aggatactgt aacctttttg tctttttttt     1380

tttttttttt tttaaacctc cacctccagt ggctgtgact ggtcccagtg attatacgtt     1440

attggttgct gtgggtctgg gcgggcctgg agccagaagg cgacttattt tttctctcct     1500

atgccacccc aggtggggag ggagggaggt ttcagactcc agtttctccc ttgccctttt     1560

attcccaagc ctccttggcc ccagtataag tgttgggaac tctctgccag cttcctgagt     1620

tctgcctaaa gatggccccc cagcactggt tggggacaag ggccaaattg gtgaccacca     1680

gtcatgccta ggacctgggg cccaaaagcc gggcaacctc tggctacagg ggccattggg     1740

tgccctccca gttgagaggg gccgctgttt cgccttgtcc gtcagtgcca gtgcctgtgc     1800

cagaggtggc gaggtgagtc ctccagagct tcctggccgg gccctcctcc tgcctgttct     1860

ggctcctctg ctcccacgct agctgtccct tttctgattc tggtggatcc tccctcccct     1920

aattaaagtc tctttttgcc cctttggggc tgcatgaggt c                         1961


<210> 2467
<211> 1692
<212> DNA
<213> Homo sapiens

<400> 2467
gggagacgct gcgcgcgggg ctagcgggcg gcggagcgga cggcgacggg gcgctctcgg       60

gctgccggcg gggccgagcg ccgcgcgtcc cgagcatggc aggctccctg cctccctgcg      120

tggtggactg tggcaccggg tattgccatc agagagtcag caaaggtagt tgaccaagct      180

caaaggagag tgttgagggg agttgatgac cttgactttt tcataggaga tgaagccatc      240

gataaaccta catatgctac aaagtggccg atacgacatg gaatcattga agactgggat      300

cttatggaaa ggttcatgga gcaagtggtt tttaaatatc ttcgagctga acctgaggac      360

cattattttt taatgacaga acctccactc aatacaccag aaaacagaga gtatcttgca      420

gaaattatgt ttgaatcatt taacgtacca ggactctaca ttgcagttca ggcagtgctg      480

gccttggcgg catcttggac atctcgacaa gtgggtgaac gtacgttaac ggggatagtc      540

attgacagcg gagatggagt cacccatgtt atcccagtgg cagaaggtta tgtaattgga      600

agctgcatca aacacatccc gattgcaggt agagatatta cgtatttcat tcaacagctg      660

ctaagggaga gggaggtggg aatccctcct gagcagtcac tggagaccgc aaaagccatt      720

aaggagaaat actgttacat ttgccccgat atagtcaagg aatttgccaa gtatgatgtg      780

gatccccgga agtggatcaa acagtacacg ggtatcaatg cgatcaacca gaagaagttt      840

gttatagacg ttggttacga aagattcctg ggacctgaaa tattctttca cccggagttt      900

gccaacccag actttatgga gtccatctca gatgttgttg atgaagtaat acagaactgc      960

cccatcgatg tgcggcgccc gctgtataag aatgtcgtac tctcaggagg ctccaccatg     1020

ttcagggatt tcggacgccg actgcagagg gatttgaaga gagtggtgga tgctaggctg     1080

aggctcagcg aggagctcag cggcgggagg atcaagccga agcctgtgga ggtccaggtg     1140

gtcacgcatc acatgcagcg ctacgccgtg tggttcggag gctccatgct ggcctcgact     1200

cccgagttct ttcaggtctg ccacaccaag aaggactatg aagagtacgg gcccagcatc     1260

tgccgccaca accccgtctt tggagtcatg tcctagtgtc tgcctgaacg cgtcgttcga     1320

tggtgtcacg ttggggaaca agtgtccttc agaacccaga gaaggccgcc gttctgtaaa     1380

tagcgacgtc ggtgttgctg cccagcagcg tgcttgcatt gccggtgcat gaggcgcggc     1440

gcgggccctt cagtaaaagc catttatccg tgtgccgacc gctgtctgcc agcctcctcc     1500

ttctcccgcc ctcctcaccc tcgctctccc tcctcctcct cctccgagct gctagctgac     1560

aaatacaatt ctgaaggaat ccaaatgtga ctttgaaaat tgttagagaa aacaacatta     1620

gaaaatggcg caaaatcgtt aggtcccagg agagaatgtg ggggcgcaaa cccttttcct     1680

cccagcctat tt                                                         1692


<210> 2468
<211> 3760
<212> DNA
<213> Homo sapiens

<400> 2468
cacaactgtc tctactgcca aggtgctaat gccgaacccc tgtgggatct ctggtccaag       60

gaaacatctg cacacaggcc agggatggcg cttagcttca tctgtgctgc aaactctcat      120

cagtaggctt gctggctctg tgaccttact agctgaactc cttaatctct ctgcacttca      180

tttttctagt ctataaaatg gagataacaa cagcacctac ctcagaagac tgttatgaag      240

actctctctc cagatcggat tcaaccgcac atcatgacag atgttccggc tacatttacc      300

caggctgagt gtaatgggga taaaccacct gaaaacggtc aacaaacaat cactaaaatc      360

agtgaggaat tgactgatgt ggacagcccc ctgccacact acagggtaga acccagtctg      420

gaaggtgcac tcaccaaagg aagtcaggag gaaagaagaa aattacaagg gaacatgctg      480

ctcaactcat ccatggagga caaaatgcta aaagaaaacc cagaagagaa actctttatt      540

gttcataagg ctatcacaga tctttctctc caagaaacta gtgctgatga aatgacattc      600

agagaagggc atcagtggga gaagattcct ctgagtggca gtaaccagga aataagaaga      660

cagaaggaga ggattactga gcagcctctc aaagaggaag aagatgagga caggaagaac      720

aaaggtcacc aggcagctga aattgaatgg ctgggatttc gaaaacctag ccaagctgac      780

atgttacatt ctaaacatga tgaggagcag aaggtttggg atgaagaaat tgatgatgat      840

gatgatgata attgcaataa tgatgaagat gaagttcgag tgatagaatt taagaaaaaa      900

catgaagagg tttctcaatt taaagaggaa ggtgatgcaa gtgaggactc cccactgagc      960

agtgccagtt cccaagctgt gacacctgat gagcagccaa ccttagggaa gaagagtgat     1020

atctccagaa atgcttattc cagatacaat acaatatcct atcggaaaat cagaaaggga     1080

aataccaagc aaagaattga tgaattcgag tctatgatgc atttataaac taactggaac     1140

tgagaaattc tcatgcccac taaaggaaaa gctaattcta ttgccccagg gtgcatattt     1200

ctatgcctta tttgagttat cacttggagg gaggtggaag ttgactctct ttttcactgt     1260

agaataatgt ggaaataacc ctagataaaa attcagtctg ataacctcaa atcaaaaagc     1320

tttaaataaa ttcttgggca tttatctttt aaaacttcac taatatagca ttgtgtgata     1380

agcactaagc agtcagtccc ctgggggaat ctggcataat tcggctataa atgtagcaat     1440

gcttggaaag gtagtcatca aatgagacta tttgagggga ctatttgaaa tgattctggt     1500

atttcttttg gtatctttct tcctgtacat tggagtgatg gaaagtctgg tattaaaacc     1560

tctcttactt ttaaacttga ttttgcagac tctggcaata agccttccaa aattctgtgc     1620

cttttctatt atcaccaaac aatatgttaa gtggctttcc ttggcatcta cagagaaaac     1680

attctatagc cctccttcct aggtgttacc attcactgaa tcttctctca gagggagatg     1740

agcaattgtc agtcaggata attctgtttg ctaaatgttg cctttatgct ttcaaactga     1800

attaaaccca ttgtgaggtt gacactggga ggggctagaa gattggtggg cagcagacta     1860

aagagttatg ttggatagtt ttatttctgt ggctgaaaat aaaatcttgt ctagcacagt     1920

taaagtcatt aaaaataaaa atgacagctt tagcacaatt ttaagaaaat gcccctctct     1980

attaccacat tttctcttat taacagtatc tcagaataat tttctttcct tagaaacctg     2040

agagaatgct agtcataact gtactagtta ctatgaaaat ggaaataatt atcttagaat     2100

attttcaaag tagagcgtga gcatgtattt ttagtgggag agctctgata gttgttggga     2160

atatataatt tactggacct cagcccaaat caagatgctt aaaattgtac ttgtggagct     2220

tcactcaaac caatgtgtca aataacgtat tgaatattta tgaaaagaga gactatattt     2280

atattcttag atagtttgtt ccacaatttt tcatttcatg cttccatata tattaccctg     2340

aactttctat caccacagat aaagattttg ttttgccctg caaataaaaa gacaattcct     2400

tattgtctga atgtaataca gtcttcattg tactattcaa ccctttgttt ctttcttttt     2460

cattttgtga aaaactccat gttagtcctc ttagatgact gcttatttat gtgtaacata     2520

aatcccacat attctaatga caacttcttt aatccttccg ggtcatatat tatatttcca     2580

tagtatcaca tactattatt tagttgttta caagactcca atttgaattc aggattacag     2640

tgctcctttc attctttcaa acagataaca taaaagttct gttaccctca ttctatacaa     2700

cctatggatt tcatgtgtta caatatcagt ttccagaata aagtgaggga aatcaggtct     2760

ttattgataa agttagggag aagattgatg caataggaca atttccaatt taatttagat     2820

cctctaatct ttctacatgg acaagctgtt ttcttttcta ggttactgat aacccctaca     2880

attttcgact taacttcaaa acacagtatt gtgttatcta tcacataaca ggaccatgtt     2940

tttaacctac catcaagagc ctgtattttg agttattcca acagagatga tggattcctg     3000

tagaactaga ggtgggtgac ctatggttat gtggcacggc aaagcaagta cctcttaagg     3060

gactctaata tatgctaacg ctggtcctct tagctctgtg ctctcaccag acaatgaatg     3120

aactatgaaa gatttagtca acagaaacta ttttagggta tgtttagttg gtaaatgctt     3180

catgttcatg gatgacacaa tgtttttgca aaaaaaccct gaaactattc tttggcattg     3240

gtgtccatgg ccctataccg ccatcttaca cgaaagccac agagttgaaa gccacagagt     3300

tgaaagccac agagttaagt gacctcaggt aacataatgg tgatggttgg ccatttgagt     3360

ctttgtaacc taggaaagac aaaggtctga ttcagattgc atgggggatt tttaacatat     3420

ttgaaactca gggggaacat gattaagaac acaaactggt agctacacat gaaggtttac     3480

ttgagctttt gtgattcaaa gttcaggggt ggtaaggact ctggtaccag ggaagaggga     3540

gaattaattt attgtgcaaa tgctggtatt tcttacatga ttttttgttt tcctctgttg     3600

ctagataaat agaaactaat aatagctcta tttctctgcc aatataaaat ctacctttca     3660

tataatgcta cattgaaggc acagaatttg ctaccatctc tctctccccc tacctaccaa     3720

actatccaca atttaaataa agaactgctg tgtctgactt                           3760


<210> 2469
<211> 1354
<212> DNA
<213> Homo sapiens

<400> 2469
ggtaaccagg agccgacaac aactcctgac gcaatggttc agccttttac taccatccca       60

tttccaccac ctccgcagaa tggaattccc acagagtatg gggtgccaca cactcaagac      120

tatgccggcc agaccggtga gcataacctg acactctacg gaagtacgca agcccacggg      180

gagcagagca gcaactcacc cagcacacaa aatggatctc ttacgcagac agaaggtgga      240

gcacagacag acggccagca gtcacagaca caaagtagtg aaaattcaga gagtaaatct      300

accccgaaac ggctgcatgt ctctaatatt cctttccgct tccgggaccc tgacctccgg      360

cagatgtttg ggcagtttgg caaaatccta gatgtagaaa taatctttaa tgaacgtggc      420

tctaagggat tcgggttcgt aactttcgag aatagtgctg atgcagacag ggccagggag      480

aaattacacg gcaccgtggt agagggccgt aaaatcgagg tgaataatgc tacagcacgt      540

gtaatgacca ataagaagat ggtcacacca tatgcaaatg gttggaaatt aagcccagta      600

gttggagctg tatatggtcc ggagttatat gcagcatcca gctttcaagc agatgtgtcc      660

ctaggcaatg atgcagcagt gcccctatca ggaagagggg gtatcaacac ttacattcct      720

ttaatcattc ctggcttccc ttaccctact gcagccacca cggcagccgc tttcagagga      780

gcccatttga ggggcagagg gcggacagta tatggtgcag tccgagcggt acctccaaca      840

gccatccccg cctatccagg tgtggtttac caggacggat tttacggtgc tgacctctat      900

ggtggatatg cagcctacag atatgcacag cctgctactg caaccgcagc caccgctgct      960

gcagccgctg cagccgctta cagtgacggt tatggcaggg tgtacacagc cgacccctac     1020

catgcccttg cccctgccgc tagctatgga gttggcgctg tggcgagttt ataccgaggt     1080

ggctacagcc gatttgcccc ctactgaagt gacgtgagac ccctgcaaat gggacagccc     1140

cccagttcat gaggcctggc tattgcaata tttactagta gaggaactct atagcaagat     1200

gaagaggaaa aacaaacaaa caaacaaaaa aaaacacaaa aaaagaaaga atactttttt     1260

atacctcact atgttctttg aatatgtatt tttcctttaa atttctgcct ttaattcttt     1320

tgttccaaag attgtgcatt tttttctttt tttt                                 1354


<210> 2470
<211> 759
<212> DNA
<213> Homo sapiens

<400> 2470
gagagactgc cagagaggaa gagaaaagaa aggaagaaac attagaaaga aaaaggaagg       60

aaaacggtat aaagagagat caattaccca cccttaaata gctagattgg ggggggaggg      120

gggtggaaaa gaaagctgtg gaggtgtgcc ccagcacggc tgctttgaaa ggtttatcat      180

ctatccgttt ggtttatgga gaaaaagaaa atggtaactc agctggaagg ctgaagtctt      240

tcacctgagc tgctgccagt tcgctcttct gttcctgggt ggttgggaga agagaagagg      300

gagggtattt tatgctttaa ttaaagacag ataagagagc agggtaacca ggagccgaca      360

acaactcctg acgcaatggt tcagcctttt actaccatcc catttccacc acctccgcag      420

aatggaattc ccacagagta tggggtgcca cacactcaag actatgccgg ccagaccggt      480

gagcataacc tgacactcta cggaagtacg caagcccacg gggagcagag cagcaactca      540

cccagcacac aaaatggatc tcttacgaca gaaggtggag cacagacaga cggccagcag      600

tcacagacac aaagtagtga aaattcagag agtaaatcta ccccgaaacg gctgcatgtc      660

tctaatattc ctttccgctt ccgggaccct gacctccggc agatgtttgg gtttggcaaa      720

atcctagatg tagaaataat ctttaatgaa cgtggctct                             759


<210> 2471
<211> 1507
<212> DNA
<213> Homo sapiens

<400> 2471
agaaaaacag tccgcgacag ctaggcgcgt gagaccggcc gcccgcaggg ctgctctggc       60

cgggacccgc tggccgggag acgcgaacct gccggaccac cgcgcgggga cgacggcggc      120

catgagctcg cggaagctga gcgggccgaa aggcaggagg ctcaggtctc ccatgtccgt      180

atgcagggga tcctcttact ggtctttgcc aagtatcagc atttgcccta tatccagatt      240

ctgtctacta aatccacccc cactggcctg tttgggtact gggggaacaa aggtggagtc      300

aacatctgcc tgaagcttta tggctactat gtcagcatca tcaactgcca cctgcctccc      360

cacatttcca acaattacca gcggctggag cactttgacc ggatcctgga gatgcagaat      420

tgtgaggggc gagacatccc aaacatcctg gaccacgacc tcattatctg gtttggagac      480

atgaactttc ggatcgagga ctttgggttg cactttgttc gggaatccat taaaaatcgg      540

tgctacggtg gcctgtggga gaaggaccag ctcagcattg ccaagaaaca tgacccgctg      600

ctccgggagt tccaggaggg ccgcctactc ttcccgccca cctacaagtt tgataggaac      660

tccaacgact atgacaccag tgagaaaaaa cgcaagcctg catggaccga tcgcatcctg      720

tggaggctga agcggcagcc ctgtgctggc cccgacactc ccataccgcc ggcgtcacac      780

ttctccttgt ctctgagggg ctacagcagc cacatgacgt acggcatcag cgaccacaag      840

cctgtctccg gcacgttcga cttggagctg aagccattgg tgtctgctcc gctgatcgtc      900

ctgatgcccg aggacctgtg gaccgtggaa aatgacatga tggtcagcta ctcttcaacc      960

tcggacttcc ccagcagccc gtgggactgg attggactgt acaaggtggg gctgcgggac     1020

gttaatgact acgtgtccta tgcctgggtc ggggacagca aggtctcctg cagcgacaac     1080

ctgaaccagg tttacatcga catcagcaat atccctacca ctgaagatga gtttctcctc     1140

tgttactaca gcaacagtct gcgttctgtg gtggggataa gcagaccctt ccagatcccg     1200

cctggctcct tgagggagga cccactgggt gaagcacagc cacagatctg agccaggatg     1260

ggagtgaatc ccaggcggag gccagagctg gcagccagct ctgcctttcc actgccggga     1320

gtgctggggg cccagcctgg ccccctgaag agacagccaa gtgtcgtcca catactcctc     1380

ccagagtgag ctctaaccag gctcatttgc tctctccact actcatctct ggaattagcc     1440

gcttaaatac aggtttttgt tgctgagatg tgagtgaaac cagctagtgt gtcaacagtg     1500

aagacct                                                               1507


<210> 2472
<211> 2738
<212> DNA
<213> Homo sapiens

<400> 2472
aagtggcaag atggctcccc tgcatgtctc cggctgatcg ctgccgctcc gccaatacaa       60

tagagccagc cactaccagc agcctggccc tcttcctcct tctccagaga gaccaatcca      120

gccgaactcg gggtttgccg tgaggactta acgcttatct cttaaaagcc agatctgttt      180

tagcctcccc gcaccaccac cacctcccct tccatttacc attttttgga tccccggttg      240

ctacatctca attttctctc tctggatcgg gtggctgggg aggaggtggt gggatcttgg      300

aacaaggaag gtgtggtttt ttttctttat tttttttagg attttttttg tttggttttt      360

gttatttctt ccattccaga aagggataaa cagcacttcc agggggagaa aaaaaatcat      420

gttatcagaa agcaaagaag gtgaggagaa ggaggaagtg accatggaca caagtgaaaa      480

cagacctgaa aatgatgttc cagaacctcc catgcctatt gcagaccaag tcagcaatga      540

tgaccgcccg gagggcagtg ttgaagatga ggagaagaaa gagagctcgc tgcccaaatc      600

attcaagagg aagatctccg ttgtctcagc taccaagggg gtgccagctg gaaacagtga      660

cacagagggg ggccagcctg gtcggaaacg acgctgggga gccagcacag ccaccacaca      720

gaagaaacct tccatcagta tcaccactga atcactaaag agcctcatcc ccgacatcaa      780

acccctggcg gggcaggagg ctgttgtgga tcttcatgct gatgactctc gcatctctga      840

ggatgagaca gagcgtaatg gcgatgatgg gacccatgac aaggggctga aaatatgccg      900

gacagtcact caggtagtac ctgcagaggg ccaggagaat gggcagaggg aagaagagga      960

agaagagaag gaacctgaag cagaacctcc tgtacctccc caggtgtcag tagaggtggc     1020

cttgccccca cctgcagagc atgaagtaaa gaaagtgact ttaggagata ccttaactcg     1080

acgttccatt agccagcaga agtccggagt ttccattacc attgatgacc cagtccgaac     1140

tgcccaggtg ccctccccac cccggggcaa gattagcaac attgtccata tctccaattt     1200

ggtccgtcct ttcactttag gccagctaaa ggagttgttg gggcgcacag gaaccttggt     1260

ggaagaggcc ttctggattg acaagatcaa atctcattgc tttgtaacgt actcaacagt     1320

agaggaagct gttgccaccc gcacagctct gcacggggtc aaatggcccc agtccaatcc     1380

caaattcctt tgtgctgact atgccgagca agatgagctg gattatcacc gaggcctctt     1440

ggtggaccgt ccctctgaaa ctaagacaga ggagcaggga ataccacggc ccctgcaccc     1500

cccaccccca cccccggtcc agccaccaca gcacccccgg gcagagcagc gggagcagga     1560

acgggcagtg cgggaacagt gggcagaacg ggaacgggaa atggagcggc gggagcggac     1620

tcgatcagag cgtgaatggg atcgggacaa agttcgagaa gggccccgtt cccgatcaag     1680

gtcccgtgac cgccgccgca aggaacgtgc gaagtctaaa gaaaagaaga gtgagaagaa     1740

agagaaagcc caggaggaac cacctgccaa gctgctggat gaccttttcc gaaagaccaa     1800

ggcagctccc tgcatctatt ggctcccact gactgacagc cagatcgttc agaaagaggc     1860

agagcgggcc gaacgggcca aggagcggga gaagcggcga aaggagcaag aagaagaaga     1920

gcaaaaggag cgggagaagg aagccgagcg ggaacggaac cgacagctgg agcgagagaa     1980

acgtcgggag cacagtcggg agagggacag ggagagagag agagaaaggg agcgggacag     2040

gggggaccga gatcgggata gggaaaggga ccgagaacga ggcagggaaa gggatcgcag     2100

ggacaccaag cgccacagca gaagccggag tcggagcaca cctgtgcggg accggggtgg     2160

gcgccgctag ctgggaaaac actagagctg caggtaccag ccactcggcc ccagggggtt     2220

atggccacag agggataggc acagtctcca ccaccctgga gccaagggtc tttcacatca     2280

cctatcccta catacatacc aaatggaaaa gtggccatcc ttttcccccc aaacacaccc     2340

ccttaaccta tctcttggga cttagcccga ccctccctct catttcccat taagtctgag     2400

aggcaagagc taggttaggc aaggaggtgg ttggccagag atggggaaca gccaggtgcc     2460

ccagtcctct gatttttcct ccatcctgct taccacctcc ctgggtactt acagccttct     2520

cttgggaaca gccggggcca ggactgggtc acctatgagc tgaatcagca tctcctcctg     2580

agtcccaggg cccctgcagt tcccagtctc ttctgtcctg cagcccttgc ctctttccca     2640

caggttccac tttatatcca ccttttcctt ttgttcaatt tttattttta ttttttttat     2700

tattaaatga tgtggtctat ggaaaaaaaa ataaaaat                             2738


<210> 2473
<211> 1792
<212> DNA
<213> Homo sapiens

<400> 2473
gctgaggacg gggcggggcc tcgcgctaac ggtcgcgcgg ccgtcgcacc tgcacgaggc       60

tgtggcccga gcgtcctgtg gagaagccgc gaagcgcggg cgacccgggg gtcgggcggg      120

ccaggtccgc gaggccgcgg cggcagctgt gcaggcccgg ggagcagccg gccgggcgag      180

cctcggatta aaaaaatggc aaactccttt gcagcgagga ttttcactac cctttcagat      240

ctgcagacaa atatggctaa tctgaaagtt atcggtatag ttattgggaa aacagatgtc      300

aaaggctttc cagacagaaa aaatattgga tcagaaaggt acactttcag cttcaccatt      360

cgggattcac cagcacattt tgtaaatgca gcttcctggg gcaatgaaga ttacatcaag      420

tctctttctg acagctttag ggttggtgac tgtgtgataa ttgaaaatcc tctgatccaa      480

agaaaggaaa tagaaagaga agaaaaattc agccctgcaa ctcctagcaa ctgtaaactg      540

ttgctcagtg agaatcactc aacagtaaaa gtttgttcca gttatgaagt ggacacaaag      600

ttactttctt tgatacattt acctgttaaa gagtctcatg attattattc actgggtgac      660

attgttgcaa atggacacag tcttaatggg aggattatta acgtgcttgc agctgtgaaa      720

tcggttggag agccaaaata ctttacaact tcagaccgga gaaaaggcca gaggtgtgaa      780

gttagactct atgatgaaac agagtcgtct tttgcgatga catgttggga taatgaatcc      840

attctacttg cacagagctg gatgccacga gaaacagtaa tatttgcctc agatgtaaga      900

ataaattttg acaaatttcg gaactgcatg acagcaactg taatctcaaa aaccattatt      960

acaactaatc cagatatacc agaagctaac attctgctga attttatacg agaaaataaa     1020

gaaacgaatg ttctggatga tgaaattgac agttatttca aagaatccat aaatttaagt     1080

acaatagttg atgtctacac agttgaacaa ttaaagggaa aagctttgaa gaatgaagga     1140

aaagctgatc cttcctatgg catcctttat gcctacattt ccacactcaa cattgatgat     1200

gaaactacaa aagtagttcg aaatagatgt tccagctgtg gttatattgt aaatgaagca     1260

tctaacatgt gcacaacttg caacaaaaac tccttggact ttaaatctgt ctttctcagt     1320

ttccatgtgc tgattgatct gactgatcac acaggcaccc ttcattcctg tagtctcaca     1380

ggaagtgttg ctgaggagac tttgggctgc acgttcgttc tatcacacag agcaaggagt     1440

ggattgaaaa ttagtgtact ctcgtgcaag cttgcagatc ctactgaggc aagcagaaac     1500

ttgtctggac aaaaacatgt ttaaaacggt ctatcatttt gaactctgga aaagtataag     1560

agttttaact ccctttaaaa tggaatatta atttgaaaat tatggggaaa attgcatttt     1620

gtttacatgt ggtgaacatg tttctagaaa ttgttatggt ggaggtggtc tgggtgagtc     1680

tgaaggcctc tctcatctga cctcccttct tagaaggcct cctactgtct ttgccttgtc     1740

tcctcccaag ttggaaaatg tttacatgaa ttaataaaca gatttaatct tc             1792


<210> 2474
<211> 969
<212> DNA
<213> Homo sapiens

<400> 2474
aaggtggctt gggagggacc agttttccta gatgcaggag acagcgtcca tagtttcagt       60

tcgaagcaac tggtggcaaa aggttagcat ttaagatggc agggacagcg cgccatgacc      120

gagagatggc gatccaggcc aagaaaaagc tcaccacggc caccgacccc attgaaagac      180

tccgactgca gtgcctggcc aggggctctg ctgggatcaa aggacttggc agagtgttta      240

gaattatgga tgacgataat aatcgaaccc ttgattttaa agaatttatg aaagggttaa      300

atgattatgc tgtggtcatg gaaaaagaag aggtggaaga acttttccgg aggtttgata      360

aagatggaaa tggaacaata gacttcaatg aatttcttct cacattaaga cctccaatgt      420

ccagagccag aaaagaggta atcatgcaag cttttagaaa gttagacaag actggagatg      480

gtgttataac aatcgaagac cttcgtgaag tatataatgc aaaacaccac ccaaagtacc      540

agaatgggga atggagtgag gaacaagtat ttaggaaatt tctggataac tttgattcac      600

cctatgacaa agatggattg gtgacccctg aggagttcat gaactactat gcaggtgtga      660

gcgcatccat tgacactgat gtgtacttca tcatcatgat gagaaccgcc tggaagcttt      720

aagcacatga cctggggacc aggccctggg acagccatgt ggctccaaat gactaaatgt      780

cagctcaaaa accagaatcg tatttgattt cacactcatc ctaatgtttt tttctgtgtc      840

aaaatattgc attttctggg gccaaaaaac aggcagaaat aaaagacatt gagtagccaa      900

ctgtgagttt gccttgccta agactgtttc ctttgttcta aaataggact taaataaaat      960

gagctctgt                                                              969


<210> 2475
<211> 1004
<212> DNA
<213> Homo sapiens

<400> 2475
gagaaaaggc agaaccagag tagagattga cagtgagctg agccaatcag gctgtgaatc       60

tgcagcagtg atcccaggtc ctccaattaa tactaagaga gtggaccagg gcccctgagg      120

aagacagatg gcagggacag cgcgccatga ccgagagatg gcgatccagg ccaagaaaaa      180

gctcaccacg gccaccgacc ccattgaaag actccgactg cagtgcctgg ccaggggctc      240

tgctgggatc aaaggacttg gcagagtgtt tagaattatg gatgacgata ataatcgaac      300

ccttgatttt aaagaattta tgaaagggtt aaatgattat gctgtggtca tggaaaaaga      360

agaggtggaa gaacttttcc ggaggtttga taaagatgga aatggaacaa tagacttcaa      420

tgaatttctt ctcacattaa gacctccaat gtccagagcc agaaaagagg taatcatgca      480

agcttttaga aagttagaca agactggaga tggtgttata acaatcgaag accttcgtga      540

agtatataat gcaaaacacc acccaaagta ccagaatggg gaatggagtg aggaacaagt      600

atttaggaaa tttctggata actttgattc accctatgac aaagatggat tggtgacccc      660

tgaggagttc atgaactact atgcaggtgt gagcgcatcc attgacactg atgtgtactt      720

catcatcatg atgagaaccg cctggaagct ttaagcacat gacctgggga ccaggccctg      780

ggacagccat gtggctccaa atgactaaat gtcagctcaa aaaccagaat cgtatttgat      840

ttcacactca tcctaatgtt tttttctgtg tcaaaatatt gcattttctg gggccaaaaa      900

acaggcagaa ataaaagaca ttgagtagcc aactgtgagt ttgccttgcc taagactgtt      960

tcctttgttc taaaatagga cttaaataaa atgagctctg taaa                      1004


<210> 2476
<211> 1990
<212> DNA
<213> Homo sapiens

<400> 2476
gtccttccca agaccacacc caggtccagt cattccctag gacttggcag agagctgtac       60

tcacagccaa gatcacagca aaatcagcaa agggaaaagg catgcagagt gaagtccaga      120

ggcaaccaga cagaagcatc cagaatcctc tcacagtggg gtcacacacc ccatgcttaa      180

ctcccccaac aatgagttgt aacaacagtc aggtgtggtg gtgtgtgcct gtagtcccag      240

ctacttggga gcctgaggca ggaggatcac ttgagtccag cagttcaaga ctgcagtgag      300

ctatgatcat accactgcac tccagcctga gtgacagagt gaaactctgt ctctaaaata      360

gggctcacct gcttgaggaa acaggaactg cctcggggca gccagccccg ccccattgac      420

gtgcagacct tgaatcgaaa cccaggctcc tgcaggcact ggcacagcta cagcgagggc      480

ctcggccatc caagggtctc ccaggccctg gtcaccttcc accagcagaa gccaattgag      540

ccgcgcaggg agctgctgac acagccctgc aggcagaagg atcccgcaaa cgtggattac      600

gaggatctct tcctctactc caacgcagtg gccgaggaag ctgcctgccc ggtgtctgcc      660

cctgaggagg cctccccaaa gccagtcctg tgtcaccaat caaaggaaag gaagccgtca      720

gcagagatga acagaataac caccaaggaa gccacttcct cctgcccccc aaaatcccct      780

cttggagaga cccgccagaa actctggagg agcctcaaaa tgctccccga gagaggccag      840

agggtccggc agcagaaaag ccacctcgcc actgtgaact tgtcgtcact cttggatgtc      900

cggagatcca cggtgatctc aggccctggg accggaaaag gcagccaaga tcactcaggg      960

gatcccacct cgggggacag aggctacacg gatccctgtg tggccacatc tctcaaaagc     1020

ccctcacagc cccaggcacc aaaagacaga aaggtcccca ccaggaaggc cgagaggtcg     1080

gtcagctgca ttgaggtgac cccaggggac aggagttggc accaaatggt agtgagagcc     1140

ctatcctccc aggagtccaa gccagagcac cagggcttgg cagagcctga gaacgaccag     1200

ctcccggagg agtaccaaca accgccaccc tttgcccctg ggtactgcta gagaacaggt     1260

ccaccctggc tctgggactc gctgccaggg gctgccacac tcctgaatgc cttaacattt     1320

cttccatggc cccacaccat ggcatccggg ggtcttcggg aacccgggaa atggaataaa     1380

gatgtttttg gggtctgttc ctgcactcac ccatggggtg agctggttat tttagcaaca     1440

atcatcagag tgacgctgat ggtttggggc accagctata catcagcccc agtgccagac     1500

cttctattca ttattttacg cctcagagca aggccctcag ggagggtcat cctccatgtt     1560

ttgaagaaga gactgaggtt cagagaggat aagaggcgtg accaaggcca cagagctatg     1620

ggtgtcagca ccaggatttg aagccaggtg aatccgagcc cttttcccat atcatctgtt     1680

tgttctgttg tctaaaagca cactgcaagc cgggctcagt ggctcatgcc tgtagtccca     1740

gcactctgtg gggccgaggc aggcagatcg cttgaggtca ggagttcgag accagcctgg     1800

ccaacatggt gaaaccccgt ctatactaaa aaattcaaaa attacccgga cgtggtggcg     1860

catgcctgta atcccagcta cttgggagcc tgaggcggga gaattgcttg aacccgggag     1920

gcagaggttg cagtgagccg agatcgcatc actgcagtcc agcctggatg acagagtgag     1980

actccatctc                                                            1990


<210> 2477
<211> 2114
<212> DNA
<213> Homo sapiens

<400> 2477
gtgtgtggag gggaccctgt ggttagcagc agctatcgca gcgtcggatg ttcagagcag       60

cagaagccgg cgtcgtcgga tgttgtgttg cccgccacca tgagctacac aggctttgtc      120

cagggatctg aaaccacttt gcagtcgaca tactcggata ccagcgctca gcccacctgt      180

gattatggat atggaacttg gaactctggg acaaatagag gctacgaggg ctatggctat      240

ggctatggct atggccagga taacaccacc aactatgggt atggtatggc cacttcacac      300

tcttgggaaa tgcctagctc tgacacaaat gcaaacacta gtgcctcggg tagcgccagt      360

gccgattccg ttttatccag aattaaccag cgcttagata tggtgccgca tttggagaca      420

gacatgatgc aaggaggcgt gtacggctca ggtggagaaa ggtatgactc ttatgagtcc      480

tgcgactcga gggccgtcct gagtgagcgc gacctgtacc ggtcaggcta tgactacagc      540

gagcttgacc ctgagatgga aatggcctat gagggccaat acgatgccta ccgcgaccag      600

ttccgcatgc gtggcaacga caccttcggt cccagggcac agggctgggc ccgggatgcc      660

cggagcggcc ggccaatggc ctcaggctat gggcgcatgt gggaagaccc catgggggcc      720

cggggccagt gcatgtctgg tgcctctcgg ctgccctccc tcttctccca gaacatcatc      780

cccgagtacg gcatgttcca gggcatgcga ggtgggggcg ccttcccggg cggctcccgc      840

tttggtttcg ggtttggcaa tggcatgaag cagatgaggc ggacctggaa gacctggacc      900

acagccgact tccgaaccaa gaagaagaag agaaagcagg gcggcagtcc tgatgagcca      960

gatagcaaag ccacccgcac ggactgctcg gacaacagcg actcagacaa tgatgagggc     1020

accgaggggg aagccacaga gggccttgaa ggcaccgagg ctgtggagaa gggctccaga     1080

gtggacggag aggatgagga gggaaaagag gatgggagag aagaaggcaa agaggatcca     1140

gagaaggggg ccctaaccac ccaggatgaa aatggccaga ccaagcgcaa gttgcaggca     1200

ggcaagaaga gtcaggacaa gcagaaaaag cggcagcgag accgcatggt ggaaaggatc     1260

cagtttgtgt gttctctgtg caaataccgg accttctatg aggacgagat ggccagccat     1320

cttgacagca agttccacaa ggaacacttt aagtacgtag gcaccaagct ccctaagcag     1380

acggctgact ttctgcagga gtacgtcact aacaagacca agaagacaga ggagctccga     1440

aaaaccgtgg aggaccttga tggcctcatc caccaaatct acagagacca ggatctgacc     1500

caggaaattg ccatggagca ttttgtgaag aaggtggagg cagcccattg tgcagcctgc     1560

gacctcttca ttcccatgca gtttgggatc atccagaagc atctgaagac catggatcac     1620

aaccggaacc gcaggctcat gatggagcag tccaagaagt cctccctcat ggtggcccgc     1680

agtattctca acaacaagct catcagcaag aagctggagc gctacctgaa gggcgagaac     1740

cctttcaccg acagccccga ggaggagaag gagcaggagg aggctgaggg cggtgccctg     1800

gacgaggggg cgcagggcga agcggcaggg atctcggagg gcgcagaggg cgtgccggcg     1860

cagcctcccg tgcccccaga gccagccccc ggggccgtgt cgccgccacc gccgccgccc     1920

ccagaggagg aggaggaggg cgccgtgccc ttgctgggag gggcgctgca acgccagatc     1980

cgcggcatcc cgggcctcga cgtggaggac gacgaggagg gcggcggggg cgccccgtga     2040

cccgagctcg gggcgggcgg agcccgcgtg gccgaagctg gaaaccaaac ctaataaagt     2100

tttcccatcc cacc                                                       2114


<210> 2478
<211> 1907
<212> DNA
<213> Homo sapiens

<400> 2478
ggcgatggcg gtcgggggtg ctggtgggag ccgcgtgtcc agcgggaggg acctgaattg       60

cgtccccgaa atagctgaca cactaggggc tgtggccaag caggggtgag ggccggacct      120

ccacgagcgg aatgcggggt ccgaactcgg ggacggagaa gggcagacta gtcatcccgg      180

agaagcaggg gtttgatttc ctctgcatgc ctgtcttcca tccgcgtttc aagagggagt      240

tcattcagga acctgctaag aatcggcccg gtccccagac acgatcagac ctactgctgt      300

caggaaggga ctggaatacg ctaattgtgg gaaagctttc tccatggatt cgtccagact      360

caaaagtgga gaagattcgc aggaactccg aggcgttgga ggtgcagttc atcatcacag      420

gcaccaacca ccactcagag aaggagttct gctcctacct ccaatacctg gaatacttaa      480

gccagaaccg tcctccacct aatgcctatg aactctttgc caagggctat gaagactatc      540

tgcagtcccc gcttcagcca ctgatggaca atctggaatc tcagacatat gaagtgtttg      600

aaaaggaccc catcaaatac tctcagtacc agcaggccat ctataaatgt ctgctagacc      660

gagtaccaga agaggagaag gataccaatg tccaggtact gatggtgctg ggagcaggac      720

ggggacccct ggtgaacgct tccctgcggg cagccaagca ggccgaccgg cggataaagc      780

tgtatgctgt ggagaaaaac ccaaatgccg tggtgacgct agagaactgg cagtttgaag      840

aatggggaag ccaagtgacc gtagtctcat cagacatgag ggaatgggtg gctccagaga      900

aagcagacat cattgtcagt gagcttctgg gctcatttgc tgacaatgaa ttgtcgcctg      960

agtgcctgga tggagcccag cacttcctaa aagatgatgg tgtgagcatc cccggggagt     1020

acacttcctt tctggctccc atctcttcct ccaagctgta caatgaggtc cgagcctgta     1080

gggagaagga ccgtgaccct gaggcccagt ttgagatgcc ttatgtggta cggctgcaca     1140

acttccacca gctctctgca ccccagccct gtttcacctt cagccatccc aacagagatc     1200

ctatgattga caacaaccgc tattgcacct tggaatttcc tgtggaggtg aacacagtac     1260

tacatggctt tgccggctac tttgagactg tgctttatca ggacatcact ctgagtatcc     1320

gtccagagac tcactctcct gggatgttct catggtttcc catcctcttc cctattaagc     1380

agcccataac ggtacgtgaa ggccaaacca tctgtgtgcg tttctggcga tgcagcaatt     1440

ccaagaaggt gtggtatgag tgggctgtga cagcaccagt ctgttctgct attcataacc     1500

ccacaggccg ctcatatacc attggcctct agccctgcgt gccaagtgtc cagagccttg     1560

gaagcagctt caggttctgc tcctgtagta cagaaggtgc agtacatcta tgggctgtga     1620

ttccccttgc ccatcagaga ggagcatttc aatctgcttt cctgccttac atcaaggtgg     1680

gcaagggatt ataattaatt gcagggctca agccaccaat ctatgaagac ctcaggccag     1740

ggggtgagga attagtgctg gatttgaagc tacgcactca gcctcaagaa ctccctggaa     1800

tatccctgag aacatggggt ttgaacggat tttcagcctt tttctgttct tgttttgatg     1860

gttttgtgta agaggaaata caaataaagt tatagccctt tactgca                   1907


<210> 2479
<211> 2418
<212> DNA
<213> Homo sapiens

<400> 2479
agtatcaagg aatcccggcg tggacagcgc gaggagaaag atggcggcga tggcggtcgg       60

gggtgctggt gggagccgcg tgtccagcgg gagggacctg aattgcgtcc ccgaaatagc      120

tgacacacta ggggctgtgg ccaagcaggg gtgagggccg gacctccacg agcggaatgc      180

ggggtccgaa ctcggggacg gagaagggca gactagtcat cccggagaag caggggtttg      240

atttcctctg catgcctgtc ttccatccgc gtttcaagag ggagttcatt caggaacctg      300

ctaagaatcg gcccggtccc cagacacgat cagacctact gctgtcagga agggactgga      360

atacgctaat tgtgggaaag ctttctccat ggattcgtcc agactcaaaa gtggagaaga      420

ttcgcaggaa ctccgaggcg gccatgttac aggagctgaa ttttggtgca tatttgggtc      480

ttccagcttt cctgctgccc cttaatcagg aagataacac caacctggcc agagttttga      540

ccaaccacat ccacactggc catcactctt ccatgttctg gatgcgggta cccttggtgg      600

caccagagga cctgagagat gatataattg agaatgcacc aactacacac acagaggagt      660

acagtgggga ggagaaaacg tggatgtggt ggcacaactt ccggactttg tgtgactata      720

gtaagaggat tgcagtggct cttgaaattg gggctgacct cccatctaat catgtcattg      780

atcgctggct tggggagccc atcaaagcag ccattctccc cactagcatt ttcctgacca      840

ataagaaggg atttcctgtt ctttctaaga tgcaccagag gctcatcttc cggctcctca      900

agttggaggt gcagttcatc atcacaggca ccaaccacca ctcagagaag gagttctgct      960

cctacctcca atacctggaa tacttaagcc agaaccgtcc tccacctaat gcctatgaac     1020

tctttgccaa gggctatgaa gactatctgc agtccccgct tcagccactg atggacaatc     1080

tggaatctca gacatatgaa gtgtttgaaa aggaccccat caaatactct cagtaccagc     1140

aggccatcta taaatgtctg ctagaccgag taccagaaga ggagaaggat accaatgtcc     1200

aggtactgat ggtgctggga gcaggacggg gacccctggt gaacgcttcc ctgcgggcag     1260

ccaagcaggc cgaccggcgg ataaagctgt atgctgtgga gaaaaaccca aatgccgtgg     1320

tgacgctaga gaactggcag tttgaagaat ggggaagcca agtgaccgta gtctcatcag     1380

acatgaggga atgggtggct ccagagaaag cagacatcat tgtcagtgag cttctgggct     1440

catttgctga caatgaattg tcgcctgagt gcctggatgg agcccagcac ttcctaaaag     1500

atgatggtgt gagcatcccc ggggagtaca cttcctttct ggctcccatc tcttcctcca     1560

agctgtacaa tgaggtccga gcctgtaggg agaaggaccg tgaccctgag gcccagtttg     1620

agatgcctta tgtggtacgg ctgcacaact tccaccagct ctctgcaccc cagccctgtt     1680

tcaccttcag ccatcccaac agagatccta tgattgacaa caaccgctat tgcaccttgg     1740

aatttcctgt ggaggtgaac acagtactac atggctttgc cggctacttt gagactgtgc     1800

tttatcagga catcactctg agtatccgtc cagagactca ctctcctggg atgttctcat     1860

ggtttcccat cctcttccct attaagcagc ccataacggt acgtgaaggc caaaccatct     1920

gtgtgcgttt ctggcgatgc agcaattcca agaaggtgtg gtatgagtgg gctgtgacag     1980

caccagtctg ttctgctatt cataacccca caggccgctc atataccatt ggcctctagc     2040

cctgcgtgcc aagtgtccag agccttggaa gcagcttcag gttctgctcc tgtagtacag     2100

aaggtgcagt acatctatgg gctgtgattc cccttgccca tcagagagga gcatttcaat     2160

ctgctttcct gccttacatc aaggtgggca agggattata attaattgca gggctcaagc     2220

caccaatcta tgaagacctc aggccagggg gtgaggaatt agtgctggat ttgaagctac     2280

gcactcagcc tcaagaactc cctggaatat ccctgagaac atggggtttg aacggatttt     2340

cagccttttt ctgttcttgt tttgatggtt ttgtgtaaga ggaaatacaa ataaagttat     2400

agccctttac tgcacgac                                                   2418


<210> 2480
<211> 2279
<212> DNA
<213> Homo sapiens

<400> 2480
gactgaaaat gccgtcggtt tcgaaagcgg cggcagcggc gctgagcggg tcccccccgc       60

agactgagaa gccgacccac tacaggtacc tgaaggagtt caggacggag cagtgccccc      120

tgttttcaca gcacaagtgc gcgcagcacc ggccgttcac ctgcttccac tggcacttcc      180

tcaaccagcg gcgccgcagg cccctccgca ggcgcgacgg caccttcaac tacagccccg      240

acgtgtactg ctccaagtac aacgaagcca ccggcgtgtg ccccgacggc gacgagtcac      300

ttctcggcgt cctctatcct ctgtgggcac cccctccggt gcctgccccc gtgggtgccc      360

ccactgtgca ccctttccta gcccggtggt tctcgcacgt tccctgggaa ccagccggca      420

gtgcagatcc acgggcctcg tccacaccag ctggggggac cacatgggcc acgggcctcc      480

taggtgattt tgatgcatgt ggctcgcagt ctcgagaatg tgttaagggg gtctggtgga      540

ccctccttgg gttcaggtgt ccctacctgc accggacgac gggggacaca gaacgcaagt      600

accacctgcg ttactacaaa acaggaacct gcatccacga gacagacgca cgtggccact      660

gcgtgaagaa tgggctgcac tgtgccttcg cgcacggccc cctggacctg cggccgcccg      720

tgtgtgacgt cagggagctg caggcccagg aagccttgca gaacggccag ctgggcggcg      780

gggaaggggt cccggatctg cagcctgggg tcttggccag ccaggccatg attgagaaga      840

tcctgagcga ggacccccgg tggcaagcat tgcttccagt cgcgctgctc aggcaccgtg      900

tggcccattt ttcagatgcc aacttcgtgc tgggcagcta caagacggag cagtgcccga      960

agccgccacg cctgtgccgc cagggctatg cgtgcccaca ctaccacaat agccgggaca     1020

ggcggcgcaa cccccggcgg ttccagtaca ggtccacgcc ctgccccagt gtgaagcacg     1080

gggatgagtg gggggaaccc tcacgctgcg atggcggcga cggctgccag tattgccact     1140

cccgcacgga gcagcagttc catcccgagg ggcctgtcgg gagtccggtg tccggggcgt     1200

tttctgtgtt cagtcacgca ggcctggttg cagaccccag tctctggtac ccagctgagt     1260

ggagctggca ccacgtgggc cacagccgca ccataaatcc tgagggagat aaaccctccc     1320

gcctgggccc cgccccagaa aatatcaagc ggggaaatga ctttgcctgt gatgggaggg     1380

cagatgctgc gggaatggcc ccacatgtgt gcgtgttccc tatctacaaa tctacaaaat     1440

gcaacgacat gcgccaaacc gggtactgcc cgcgcggccc cttctgtgcc tttgcacacg     1500

ttgagaagag cctggggatg gtgaatgaat ggggctgtca cgacctccac ctcacgagtc     1560

cttcctccac gggcagcggc cagccgggaa atgccaagcg gagagactcg ccggccgagg     1620

gtggccctag gggcagcgag caagacagca agcagggggt gcgcgctcac ggtgtttatg     1680

tctttgaaca gaaccacctg gccgtgtttg cagcggtcca cccgccggcc cccagcgtga     1740

gctccagcgt ggcgtccagc ctggcgtcca gcgccggctc cggcagctcc tcccccactg     1800

cgctgcccgc gccccccgcc cgtgccctcc cgctcggccc cgccagcagc actgtggagg     1860

ccgtcctcgc cctggagccc accccttcct ctcctacatc ctctgctgtg cagggtgtgg     1920

cgggggagct gggcatggga tcaggaggac agggctgctg gagccacgtg gtgggggccc     1980

tcgctgcagt ccctgcctgg acacactctg gggacttgga gtgggacccc agcaccatca     2040

ggacccgcgt caatgtgggc ggcggcccgg cggccagacc cgcaatgact cttgcccgag     2100

agccgcagct tctggtcgtt ggtggttgcc ccacacggaa ctgctcaggc ccagctgcaa     2160

gcccccagca actcctagac gatgccggcc aaggaggccg aggagagaga gactcttccc     2220

agcggccact taggccacag accacacatc ggcaggacac tagaccagtc ccatcctga      2279


<210> 2481
<211> 2180
<212> DNA
<213> Homo sapiens

<400> 2481
tttgaatccc cggcggcggc gcggggcggc cgcggaccgt gagtcagcat tggcggcggc       60

cccagcgcgt ggcagccgtg cgccgccaag gtgcgggtct cgttactcgg cggtcaggag      120

cgggccctcc cttaggtgcg ccccccgcca ggttctgcgt tagacctgca tcttagcaat      180

gtgaatattg catccctaga gaaggacctg gaagagcaag acggccacga cctgggagca      240

gcaggtccca ggtcgctggc cggctctgca cctgtcgcca tccccggctc cctgcccaga      300

gcaccatcgc tacactcgcc atcctctgcg tccacctcgc cgctcggttc gctgtcccag      360

cccctcccag ggccggtggg ctcctcagcc atgacgcctc cccagcagcc gccacccctg      420

cgttcagagc cgggcacact gggctctgca gcctcatcct acagccccct aggtttgaac      480

ggtgtccccg ggagcatctg ggactttgtt tccggcagct tctcccccag cccctccccc      540

atcctgagtg ccggcccccc atcctcttcg agtgcaagtc caaacggagc tgagctggcc      600

cgggtcaggc ggcagctgga cgaggccaag aggaagatcc ggcagtggga ggagtcctgg      660

cagcaggtga agcaggtctg cgatgcctgg cagcgagagg cgcaggaggc caaggagcgt      720

gcccgtgtgg ccgatagcga ccggcagctg gcgctgcaga agaaggagga ggtggaggca      780

caggtgatct tccagctccg cgccaagcag tgtgtggcct gccgggagcg ggcccacggt      840

gctgtcctgc ggccctgtca gcaccacatc ctctgtgagc cgtgtgcggc caccgcacct      900

gagtgcccct actgcaaggg ccagcccctg cagtggtgac ctcagcgggg acagccacct      960

cctgctgggc accctggctc cagcgctcct cctgaccacg gacatgtcgt cactcgcttc     1020

tggtgccacc gacgtgagga ccgaggctgg gagcccttcc tgttacacgt tatcatgagg     1080

ctgggagccc cgcctgcgct tggcctgaca gcctttcctg tcacacgttg tcacctatct     1140

agtcctaccg acggtttcaa ggtattttcc tcaaaaacct taaatgcaaa cccacagaac     1200

ccgcctgcct gtccctgagg ggcctggtgc ctccgggatc cacgcggcgc tgtgatcaca     1260

gcagtttgtg gtcctgacac tactgtgact aggccactgg gagctggggt ctttcaaagc     1320

actttgtaaa ccgaggaatt tagttagagg ttataaattg ctctaagctg ctttctgttt     1380

ttttttaata tgcgataata tgaagcttta tatgtgtact gtgaacttaa atatttcata     1440

tcagtttatt gtcaattcat agtatgctaa atatattaga tttcatattc tgaaactagt     1500

acttatgaaa tgagtgttta tctagtagta agacctagga tttttacatt ttccaattaa     1560

gtgcaaatag tatttataag cagagtgatt atggattgag atgtttttaa cttgatggaa     1620

ggagctagtt ttcctgagcc tgtgtgtgca ccaggcactg gggctgatgt tccagcctcg     1680

tggcgtggga gcaggagagc tccgtcctgc atttctgtgg tccgtggccg ctgtttctgt     1740

gcgcctgcgc ctcggagagc aagtgaagga gcatcatggg ttttgttttc tcccttaacc     1800

ctctgaaaga cagtttgata ctaacaaaaa acgcagcaga ggggatccga cgtcagagct     1860

tttagaatta cttttttaag cagctgtctt ctggctgggt gcggtggctc atgcctgtga     1920

tcccagcact ttgggaggcg ggtggatcac ctaaggtcag gagttcaaga ccagcctggc     1980

caacatggtg caaccccgtc ttagtaaaaa tacaaaaatt ggcctggcgt gagagcgggc     2040

acctgtagtc ccagctactc gggaggctga ggcaggagaa tcgcttgaac ctgggaggca     2100

gaggttgcag tgagccgaga tcgcgccacc gcactccagc ccgggtgaca gagcgagact     2160

ctggctcaaa aaaaaaaaaa                                                 2180


<210> 2482
<211> 500
<212> DNA
<213> Homo sapiens

<400> 2482
gaggcctgcg cgtgcggtct gcagttcggc cgcttcctct tggcgggtgg gctgcagcta       60

tggagggcga gcctccacct gtggaggagc ggcggcggct gcaggaggag ctgaacgagt      120

tcgtggagag cggctgccgg acgttggagg aggtgaccgc gtccctgggc tgggacctag      180

atagtctgga tcccggggaa gaggaggcgg cggaggatga agttgtgata tgtccatacg      240

attccaatca tcacatgcct aaatcatctt tggcaaagca catggcatct tgtagattga      300

ggaaaatggg ctataccaaa gaagaagagg atgaaatgta taatcctgag tttttctatg      360

aaaatgtgaa gataccttcg attactttga ataaggactc acaattccag ataattaaac      420

aagctagaac tgcagttggg aaagacagtg attgttataa tcaaataatt ggggtgagta      480

taaagaggaa ttataaaatt                                                  500


<210> 2483
<211> 776
<212> DNA
<213> Homo sapiens

<400> 2483
atggggacct ttgacctgtg gacagattac ctgggtttgg cacacctggt tagggctctg       60

agtgggaaag agggtcctga aaccaggctg agcccccagc cagagccaga gccaatgctg      120

gagccggatc agaagcgcag cctggagtcc tcgccagctc ccgaacgcct gtgctctttc      180

tgcaaacaca acggcgagtc ccgggccatc taccagtccc acgtgctgaa ggacgaggct      240

ggcagggtgc tgtgtcccat cctgcgggac tacgtgtgtc cccagtgcgg cgccacacgt      300

gagcgcgccc acacccgacg cttctgccca cttactggcc agggctacac ctccgtctac      360

agccacacca cccgaaactc ggcaggcaag aagctggtcc ggcctgacaa ggcgaagaca      420

caggacacag gccaccgccg aggaggagga ggaggagcag gtttcagagg tgccgggaag      480

tctgagcctt cgccctcctg ctctccctcc atgtccacct aggaggctgc ctacacctgg      540

gcaagggcac ccgggctcgg ctggatttcc aggaagaccc accctatgac gactgccccc      600

actcccagac cctcccccca gcctgggatt gagccctggg gatgacccgg ggttggcaag      660

ggaagagctg aaatcgccct gtccttgggg accccaccct ttgtgccatc tgccgtttcc      720

ctagtgctgg gcatccagtc agccctcaat aaatgcttat gaatggatca acaaca          776


<210> 2484
<211> 3055
<212> DNA
<213> Homo sapiens

<400> 2484
atgtccgctt tctgcctggg cttggtcggc cgcgcttcag cacccgccga gccggacagc       60

gcctgctgca tggagctgcc cgccgcggcc ggggacgcag tccggagtcc cgccgccgcc      120

gccgccctca tcttccccgg gggctccggg gagctagaac tggcgttaga ggaggagctg      180

gcgctgctgg cggccgggga gcggccgtcc gaccccgggg aacaccctca ggccgagcct      240

gggtctctgg ccgagggggc cggaccgcag ccgccgccct cccaggaccc cgagctgctg      300

tcggtgatcc gacagaagga gaaggatctg gtgttggcgg cccggctggg taaggcgctg      360

ctcgagagga accaggacat gagccggcag tacgagcaga tgcataagga gctgacagac      420

aagctcgagc acttagagca agagaaacat gaattgagaa gacgatttga gaaccgagaa      480

ggggagtggg aaggccgagt gtcagagctg gagagtgatg tgaagcagct acaggatgag      540

ttggagaggc agcagattca tctgcgggaa gcagatcgag aaaaatcacg ggctgtccag      600

gaactgtcgg aacagaacca aaggctattg gatcagctca gcagggcatc agaagttgag      660

agacaactct ccatgcaggt ccacgccctc agagaagact ttcgggagaa aaactcatca      720

accaaccagc acattatccg gctggagagc cttcaggccg agatcaagat gctgtcagat      780

cggaaacggg agctggagca tcgtctcagc gctactttag aggaaaatga cctgctccaa      840

gggaccgtgg aggagctaca ggaccgggtg ctaatcctgg agaggcaggg ccatgacaag      900

gacctacagc tgcaccaaag ccagctggag cttcaggagg tgcgtctctc ctgccgacag      960

ctgcaggtga aggtggaaga actcactgag gagaggagtc tgcagagctc tgccgccacc     1020

agcacatccc tcctgtcaga gatcgagcag agcatggagg ctgaggagct ggagcaggag     1080

cgagagcagc tgagactgca gctctgggaa gcctactgcc aggttcgcta tctgtgctca     1140

caccttcgag gcaatgacag tgctgactca gccgtctcca cggactcctc catggacgag     1200

tcttcagaaa cctcgtccgc caaggatgtg ccagccggca gcttgcgcac tgccctcaat     1260

gagctcaaga gactgataca gagcattgtg gatggcatgg agcccacggt gacactgctg     1320

agtgtggaga tgactgccct aaaagaggag agagaccgac tcagagtcac ttctgaggac     1380

aaggagccaa aggagcagct tcagaaggcc atcagggacc gcgacgaggc cattgcaaag     1440

aagaatgctg tggagctgga acttgccaag tgcaggatgg atatgatgtc tctgaacagc     1500

cagttgctgg atgccattca gcagaaactg aacctctcgc agcagctgga agcttggcag     1560

gatgacatgc acagggtcat tgaccggcag ctgatggaca cgcacctgaa agaacggagc     1620

cagccggctg ctgccctctg caggggccac agcgctgggc ggggggatga gcccagcatc     1680

gctgaaggca aacgactctt ctcattcttc aggaaaattt aagttgggag gagtcaggcc     1740

accaaagatg ggtggactgg aggcagctgg aaaggcggtg caggcaaggc ctcccctgca     1800

gcttgcacct cagcagctgc cctgcccctc atgctagggc cccatgggtc cgggagggcc     1860

tgctcccttt cgtcggtggg gatggagacc tagaggtggg ggcctgcctt ggccactgaa     1920

ggcttccctt ggcccaccgc ctggccaagc ccacgcctgg gcttctccag gaccacgtgc     1980

ttgagcaggg ttaggccacc tcccagaggg gccccttggt gttgggcttt gcagctcaca     2040

cccaacagat cgcagcccac ccccaggcac tgctgcctcc ttgattttag caaatgggga     2100

acagaaggaa tggaggccct tctctgcatg cctcaggagg cctgagcccc aggggcctag     2160

acctgtgggg gcagcgggcc aggcctgagc ctccattcct tccccagccc ctggcccagg     2220

gtcaaaggag agatggcagc ccctcccccg catgcatgca cctcagctgg caggaggcca     2280

agcctctggc cgcagggtct aagagccggg gcttacccaa gctcagctga ggccacccga     2340

gccccaggga ggaagaaggc cctgtccccc tgtcgccact gctctccctc ccagccttca     2400

gtctctgccc cttagcaggg cctggccagg cagagtgtta tcaccagtca tctgcaggct     2460

ttagccatcc agccctttcc cctgctcagg gctggggttg gacggggtct cctcctccca     2520

cagctccctc ctccacccct cacatacata cataatttct tggcctagcc aaacaagtcc     2580

aggccactga atggcaccag aggggtctgt ggtcagccac cccaccttga gggcagcaca     2640

ggcaccacgg ggtggagggg agggggaggc tgccggaagc ctccagatgc tgcctgcctg     2700

cctgcagaag cctgcagtgg ctgctgctcc tgcctctgca gccgcccctc ctcctccacc     2760

caggccccaa ctcagaggct ccgcggcccg gccagccctc agctgctcac aaccgattca     2820

gtctccctcc ctccctcacg tggggaaagc acagcaggga tgcgcggcaa gaatgtacct     2880

gtagatgtgt acataccaca gtgctgtaat tttgtatgta gcaatcatgt aaatacatgt     2940

atggatttta taatatacat atataaaaat ctataaaggc atatttttag aaaaacagca     3000

caccactgct tcttttgaaa atagtctgaa taagaataaa atgaatttct acaga          3055


<210> 2485
<211> 4487
<212> DNA
<213> Homo sapiens

<400> 2485
caggaaactc cagcacctcc tagaacatct tttgtggaat ggcacctcat gggggccctt       60

ggatcatgta ccccttgtat tcaacagtaa acatcttcct ataatcattg cttcattaac      120

gataatgttt atcatttaaa agtgcctgtg tgaagtcact tttgctggaa aactgcagct      180

tgggagcttt ctttgtattc acatcccact cttctgtcaa gtacacttta ccctgacctt      240

atgagtggat gaagatacct cagttgtctg actttgccaa ttgcttaatt tcagaattta      300

aaaaggggaa agaaaaacat cctgctaaaa tatgaacatc tgagtgtctt attttccaac      360

atcgtcaata gctgtgagcg tcagcattaa atattctccc aaggagtgcc atgatattga      420

agtcacttta ttaataacag ctgtatctgc aaaacagtca agagactcgg acgttgaaag      480

ccagagatga cactgagcat gcttttattg cggcctacca tctttaagtg ggacatattg      540

attgatgagt gattgcctgt ccatacactc tctcatcatc ctgttccttg gattggactt      600

cactaagcaa tttatcactc accttcagac ttacatgtgg gagttttcac aacagtagtt      660

ttggaatcat tagaacttgg attgatttca tcatttaaca gaaacaaaca gcccaaatta      720

ctttatcacc atggctttga acgttgcccc agtcagagat acaaaatggc tgacattaga      780

agtctgcaga cagtttcaaa gaggaacatg ctcacgctct gatgaagaat gcaaatttgc      840

tcatcccccc aaaagttgtc aggttgaaaa tggaagagta attgcctgct ttgattccct      900

aaagggccgt tgttcgagag agaactgcaa gtatcttcac cctccgacac acttaaaaac      960

tcaactagaa attaatggaa ggaacaattt gattcagcaa aaaactgcag cagcaatgct     1020

tgcccagcag atgcaattta tgtttccagg aacaccactt catccagtgc ccactttccc     1080

tgtaggtccc gcgataggga caaatacggc tattagcttt gctccttacc tagcacctgt     1140

aacccctgga gttgggttgg tcccaacgga aattctgccc accacgcctg ttattgttcc     1200

cggaagtcca ccggtcactg tcccgggctc aactgcaact cagaaacttc tcaggactga     1260

caaactggag gtatgcaggg agttccagcg aggaaactgt gcccggggag agaccgactg     1320

ccgctttgca caccccgcag acagcaccat gatcgacaca agtgacaaca ccgtaaccgt     1380

ttgtatggat tacataaagg ggcgttgcat gagggagaaa tgcaaatatt ttcaccctcc     1440

tgcacacttg caggccaaaa tcaaagctgc gcagcaccaa gccaaccaag ctgcggtggc     1500

cgcccaggca gccgcggccg cggccacagt catggccttt ccccctggtg ctcttcatcc     1560

tttaccaaag agacaagcac ttgaaaaaag caatggtacc agcgcggtct ttaaccccag     1620

cgtcttgcac taccagcagg ctctcaccag cgcacagttg cagcaacacg ccgcgttcat     1680

tccaacagat aattctgaaa taatcagcag aaacggaatg gaatgccaag aatctgcatt     1740

gagaataact aaacattgtt actgtacata ctatcctgtt tcctcctcaa tagaattgcc     1800

acaaactgca tgctaaataa agatgtagtt cttctggaca gaccacaact ctaagaagct     1860

agtgctgcta tctcatatat gagtattaaa tatggtatgc ttagtatatt ccaacctaag     1920

atagttaact acctgagacc agctgtgatg tttaaagaca taaaggataa agtttacttt     1980

taaagggttt ctaaacatag tttctgtcct aggaatattg tcttatctcc ataactatag     2040

ctgatgcaga aagtccagcc agtttactca tttcgattca gaatatttca aatttagcaa     2100

taaacaatta gcattagtta aaaaagaaac atattccaag ggcaggttcg attctagctc     2160

taattactgt catgtcattt acccactgga tcaaagggta tgtttcactt cttgacaata     2220

taaatgctgc agcaaagatg agaggtgaag taaaaccgat acctgtcctg caggtctaaa     2280

atttgaatgg aaattcaagc acaagtactg gggacacatc aaagtgtggt gtttggtttg     2340

cctggagatg ccacgttgaa tcatgtgatt ctagattaac attaaataga ttgaaaaaga     2400

aactttgcac ggtatgagct tcatacccca ccaaacaaag tcttgaaggt attattttac     2460

aagtatattt ttaaagttgt tttataagag agactttgta gaagtgccta gattttgcca     2520

gacttcatcc agcttgacaa gattgagagg cccatgccaa cagtctaatc taagagatta     2580

gtctttcaaa ctcaccatcc agttgcctgt tacagaataa ctcttcttaa ctaaaaacct     2640

agtcaaacaa ggaagctgta ggtgaggaga tctgtataat attctaattt aagtaagttt     2700

gagtttagtc actgcaaatt tgactgtgac tttaatctaa attactatgt aaacaaaaag     2760

tagatagttt cactttttaa aaaatccatt actgttttgc atttcaaaag ttggattaaa     2820

gggttgtaac tgactacagc atggaaaaaa atagttcttt taattctttc accttaaagc     2880

atattttatg tctcaaaagt ataaaaaact ttaatacaag tacatacata ttatatatac     2940

acatacatat atatactata tatggatgaa acatatttta atgttgttta cttttttaaa     3000

tacttggttg atcttcaagg taatagcgat acaattaaat tttgttcaga aagtttgttt     3060

taaagtttat tttaagcact atcgtaccaa atatttcata tttcacattt tatatgttgc     3120

acatagccta tacagtacct acatagtttt taaattattg tttaaaaaac aaaacagctg     3180

ttataaatga atattatgtg taattgtttc aaacatccat tttctttgtg aacatattag     3240

tgattgaagt attttgactt ttgagattga atgtaaaata ttttaaattt gggatcatcg     3300

cctgttctga aaactagatg caccaaccgt atcattattt gtttgaggaa aaaaagaaat     3360

ctgcatttta attcatgttg gtcaaagtcg aattactatc tatttatctt atatcgtaga     3420

tctgataacc ctatctaaaa gaaagtcaca cgctaaatgt attcttacat agtgcttgta     3480

tcgttgcatt tgttttaatt tgtggaaaag tattgtatct aacttgtatt actttggtag     3540

tttcatcttt atgtattatt gatatttgta attttctcaa ctataacaat gtagttacgc     3600

tacaacttgc ctaaaacatt caaacttgtt ttcttttttc tgtttttttc tttgttaatt     3660

catttaaact cattgaaaac atagtataca ttactaaaag gtaaattatg ggaatcactg     3720

aaatattttt gtagattaat tgttgtaaca ttgtctttct tttttttctt ttgtttcatg     3780

attttgattt ttaaaattat tagcacacaa ctattttcag ccctttaata atggagcatc     3840

aaaaacatca cctgtaaccc caagcaaata tagaagactg tattttttac tatgatatcc     3900

attttccaga attgtgatta caatatgcaa agagtcataa atatgccatt tacaataagg     3960

aggaggcaag gcaaatgcat agatgtacaa atatatgtac aacagatttt gctttttatt     4020

tatttataat gtaattttat agaataattc tgggatttga gaggatctaa aactattttt     4080

ctgtataaat attatttgcc aaaagtttgt ttatattcag aagtctgact atgatgaata     4140

aatcttaaat gctttgttta attaaaaaac aaaaatcacc aatatccaag acatgaagat     4200

atcagttcaa caaatactgt agttaagaga ctaactctcc acttgtatgg gaactacatt     4260

tcactcttgg ttttcaggat ataacagcac ttcaccgaaa tattctttca gccataccac     4320

tggtaacatt tctactaaat ctttctgtaa cacttaaaga attccctcat tcattacctt     4380

acagtgtaaa caggagtcta atttgtatca atactatgtt ttggttgtaa tattcagttc     4440

actcacccaa tgtacaacca atgaaataaa agaagcattt aaaagga                   4487


<210> 2486
<211> 3702
<212> DNA
<213> Homo sapiens

<400> 2486
aggaaatttc ggggaaccaa aaaaggctgg aagaacatga agatggagca gtcataaacc       60

acccactcaa ggaccatctc cttcaggacc atccacacga gactcagatt gtctgaattg      120

agctatcgca acttaatgct aaaagctcct taaagctaca gatttatgac atagttcctt      180

ccaaaatatt acatcataaa tcattgagaa gattaaaaaa aaacacttga agaaattgta      240

gttttaaaca tctctgcata tattttggat agctactagg ttactttaac tgtcattaag      300

gagcacagac ttactgaagc tttactggac agaatcctgg gaaatcgata tcattataag      360

gttatatttc ccagttagcg ggtgaagggc tggagacctt attgcagtca tggctttcac      420

aaattacagc agtctgaatc gagctcagct aacctttgaa tatctgcaca caaattcaac      480

cactcacgaa ttcttgtttg gtgcccttgc tgaactggtt gataatgcaa gagatgctga      540

tgccaccaga atagatattt atgcagaaag acgagaggac cttcgaggag gatttatgct      600

ttgctttttg gatgatggag caggaatgga tccaagtgat gctgccagtg tgatccagtt      660

tgggaagtcg gccaagcgaa cacctgagtc tactcagatt gggcagtacg ggaatgggtt      720

aaaatcgggc tcaatgcgca ttgggaagga ttttatcctg ttcaccaaga aggaagacac      780

catgacctgc ctcttcctgt ctcgcacgtt tcatgaggaa gaaggcattg atgaagtgat      840

agtcccactg cccacctgga atgctcggac ccgggaacct gtcacagaca atgtagagaa      900

atttgccatt gagacagaac tcatctataa gtactctcca ttccgcactg aggaggaagt      960

gatgacccag tttatgaaga ttcctgggga cagcggaaca ttggtgatca tcttcaatct     1020

caaactcatg gataatggag agccagaact agacataatc tcaaatccaa gagatatcca     1080

gatggcagag acgtccccag agggcacgaa gccagagcgg cgctcgttcc gtgcctatgc     1140

cgctgtgctc tatattgatc cccggatgag gatcttcatc catgggcaca aggtgcagac     1200

caagaggctc tcctgctgcc tgtacaagcc caggatgtac aagtacacgt caagccgttt     1260

caagacccgt gcggagcagg aggtgaagaa agcagagcac gtagcaagga ttgctgaaga     1320

gaaggcgcgg gaggcagaga gcaaagctcg gacattagaa gtacgcctag gtggagacct     1380

cacgcgggac tccagggtga tgttgcgaca ggtccagaac agagccatca ctctgcgcag     1440

agaagccgat gtcaagaaga ggatcaagga ggccaagcag cgagcactta aagaacctaa     1500

ggaactgaat tttgtttttg gtgtcaacat tgaacaccgg gatctggatg gcatgttcat     1560

ctacaactgt agccgactga tcaaaatgta tgagaaagtg ggcccacagc tggaaggggg     1620

catggcatgt ggcggggttg ttggggttgt tgatgtgccc tacctggtcc tggagcctac     1680

acacaacaaa caggactttg ctgatgccaa ggagtaccgg cacctgctcc gagcaatggg     1740

ggagcacctg gcgcagtatt ggaaggatat tgccatcgcc cagaggggaa tcatcaagtt     1800

ctgggatgag tttggctacc tctctgccaa ctggaaccag cccccatcca gtgagctgcg     1860

ttacaaacgc cggagagcta tggaaatccc caccaccatc cagtgcgatt tgtgtctgaa     1920

atggagaacc ctccccttcc agctgagttc tgtggaaaaa gattaccctg acacctgggt     1980

ttgctccatg aaccctgatc ctgaacagga ccggtgtgag gcttctgaac aaaagcagaa     2040

ggttcccctg ggaacattca gaaaggacat gaagacgcag gaagagaagc agaaacaact     2100

gacagagaaa attcgccagc agcaggagaa gctggaggcc cttcagaaaa ccacacccat     2160

ccgctcccaa gcagacctga agaaattgcc cttggaagtg accaccagac cttccactga     2220

ggaacctgtg cgtagacctc agcgtcctcg gtcgccccct ttacctgctg tgatcaggaa     2280

cgcccccagc agaccccctt ctttgccaac tcctagacca gccagccagc cccgaaaggc     2340

tcctgtcatc agcagtaccc caaagctccc tgctttggca gcccgggagg aggccagcac     2400

atctaggctg ctccagccac ctgaggcacc ccgaaagcct gccaacactc tcgtcaagac     2460

tgcatcccga cctgcccctc tggtgcagca actgtcacca tctttactgc ccaactccaa     2520

gagccctcgg gaggttcctt ctcccaaagt catcaagact ccagtggtga agaagacaga     2580

gtcacccatc aaactctccc cggctacccc tagtcggaag cggagtgtcg cagtttctga     2640

tgaggaagaa gttgaggagg aagctgagag gaggaaggag aggtgcaagc ggggcagatt     2700

tgttgtgaag gaggaaaaga aggactcgaa tgagctctca gacagtgctg gggaagagga     2760

ctcggctgac ctcaagagag ctcagaaaga taaagggctg cacgtggagg tgcgtgtgaa     2820

cagggagtgg tacacgggcc gtgtcacagc cgtggaggtg ggcaagcatg tggtgcggtg     2880

gaaggtgaag tttgactacg tgcccacaga cacgacacca agagaccgct gggtggagaa     2940

aggcagtgag gatgtgcggc tgatgaaacc cccttctccg gaacatcaga gccttgatac     3000

acaacaggag ggcggggagg aggaggtggg ccctgtggcc cagcaggcca tagctgtcgc     3060

agagccctcc acttccgaat gcctccgcat tgagcctgac accactgccc tgagcaccaa     3120

tcacgagacc atcgacctgc ttgtccagat cctccggaat tgtttacggt acttcctgcc     3180

tccaagtttc cccatctcca agaagcagct gagtgctatg aattcagatg agctaatatc     3240

ttttcctctg aaggagtact tcaagcaata tgaagtaggg ctccaaaacc tgtgcaattc     3300

ctaccagagc cgtgctgact cccgggccaa ggcctccgag gaaagcctgc gcacctccga     3360

gaggaagctc cgcgagacgg aggagaagct gcagaagctg aggaccaaca tcgtggcact     3420

cctgcaaaag gtgcaggagg acatagacat caacacagat gatgagctgg acgcctacat     3480

tgaggacctc atcaccaagg gggactgaag gcaggagaga gagcagctcc cctgcccacc     3540

tgcccctcaa ccctgtagct gcagggggag gggacttcat tcatgggttg gtggtcgcac     3600

cttggtttga cttacacggg acatttgtgt ttttggagga aaagataccc tgattctttg     3660

aatcttcctt aagtttataa atatttattt tttaaaagaa ga                        3702


<210> 2487
<211> 6333
<212> DNA
<213> Homo sapiens

<400> 2487
agtgctgagc gaaccggaag tcggtccgcg gcgttttctg cccgcggtgc gcagcgctga       60

gtgtcgcggc agcagcctgt gcttgcgcct caagtctttc cgaggggcca gtgggcagcg      120

cgggcctcgg ggtcctgggg cgagacgctt gttctaaaga cgaaggggaa ctccctagtg      180

ctacaggctg tttcaggaag ccaattaatt ttgtacacat aatacttaat taccttctaa      240

taattggagc agaagatgaa cccaactaat cctttcagtg ggcagcagcc tagtgctttt      300

tcggcgtctt ctagtaatgt aggaacactt ccatctaagc cgccatttcg atttggtcaa      360

ccttctcttt ttggacaaaa cagtacctta tctgggaaga gctcgggatt ttcacaggta      420

tccagctttc cagcgtcttc tggagtaagt cattcctctt cagtgcaaac attagggttc      480

acccaaacct caagtgttgg acccttttct ggacttgagc acacttccac ctttgtggct      540

acctctgggc cttcaagttc atctgtgctg ggaaacacag gatttagttt taaatcaccc      600

accagtgttg gggctttccc aagcacttct gcttttggac aagaagctgg agaaatagtg      660

aactctggtt ttgggaaaac agaattcagc tttaaacctc tggaaaatgc agtgttcaaa      720

ccaatactgg gggctgaatc tgagccagag aaaacccaga gccaaattgc ttctgggttt      780

tttacatttt cccacccaat tagtagtgca cctggaggcc tggccccttt ctcttttcct      840

caagtaacaa gtagttcagc taccacttca aattttacct tttcaaaacc tgttagtagt      900

aataattcat tatctgcctt tacccctgct ttgtcaaacc aaaatgtaga ggaagagaag      960

agaggaccta agtcaatatt tggaagttct aataatagct tcagtagctt ccctgtatca     1020

tctgcggttt tgggcgaacc tttccaggct agcaaagcag gtgtcaggca ggggtgtgaa     1080

gaagctgttt cccaggtgga accacttccc agcctaatga aaggactgaa aaggaaggag     1140

gaccaggatc gctccccaag gagacatggc cacgagccag cagaagattc ggatcctctg     1200

tcccggggcg atcatcctcc agacaaacga cctgtccgcc tgaatcgacc ccggggaggt     1260

actttatttg gtcggacgat acaggatgtt ttcaaaagca ataaggaagt aggtcgtctg     1320

ggcaacaagg aggccaaaaa ggaaactggc tttgttgagt ctgcagaaag tgaccacatg     1380

gctatcccag gagggaatca gtctgtcctg gcaccttccc ggattccagg tgtgaataaa     1440

gaggaagaaa ctgaaagtag agagaagaaa gaagattctc taagaggaac tccggcgcgt     1500

cagagtaaca gaagcgagag cacagacagt cttgggggct tgtctccctc tgaagtcaca     1560

gccatccagt gcaagaacat ccctgactac ctcaacgaca ggaccattct ggagaaccat     1620

tttggcaaaa ttgctaaagt gcagcgcatc tttaccaggc gcagcaaaaa gcttgcagtg     1680

gtacatttct ttgatcatgc atctgcagcc ctggctagaa agaaggggaa aagtttgcat     1740

aaagacatgg ctatcttttg gcacaggaag aaaataagcc ccaataagaa acccttttcc     1800

ctgaaggaga agaaaccagg tgacggtgaa gtcagcccga gcacagagga tgcacccttt     1860

cagcactctc ctcttggcaa ggccgcaggg aggactggtg ctagcagcct cctgaataaa     1920

agctctccag tgaagaagcc aagtcttcta aaggcccacc aattcgaggg agactctttt     1980

gactcagcct ccgagggctc cgagggcctc gggccatgtg tgctctccct cagtaccctg     2040

ataggcactg tggctgagac atccaaggag aagtaccgcc tgcttgacca gagagacagg     2100

atcatgcggc aagctcgggt gaagagaacc gatctggaca aagcgaggac ttttgttggc     2160

acctgcctgg atatgtgtcc tgagaaggag aggtacatgc gggagacccg tagccagctg     2220

agcgtgttcg aagtggtccc agggactgac caggtggacc acgcagcagc tgtgaaagag     2280

tacagtcggt cctcggcgga tcaggaggag cccctgcccc acgagctgcg gcccttgcca     2340

gtgctcagca ggaccatgga ctacctggtg acccagatca tggaccagaa ggagggcagc     2400

ctgcgggatt ggtatgactt cgtgtggaac cgcacgcgtg gcatacggaa ggatatcacg     2460

cagcagcacc tctgtgaccc cctgacggtg tccctgattg agaagtgcac ccggtttcac     2520

atccactgtg cccacttcat gtgtgaggag cccatgtcct cctttgatgc caagatcaat     2580

aatgagaaca tgaccaagtg cctgcagagc ctgaaggaga tgtaccagga cctgagaaac     2640

aagggtgtct tctgtgccag cgaagcggag ttccagggct acaatgttct gctcagtctc     2700

aacaagggag acatcctaag agaagtacaa cagttccatc ctgctgttag aaactcatct     2760

gaggtgaaat ttgctgttca ggcttttgct gcattgaaca gtaataattt tgtgagattt     2820

ttcaaactgg tccagtcagc ttcttacctg aacgcttgtc ttttacactg ttacttcagt     2880

cagatccgca aggatgctct ccgggcgctc aactttgcgt acacggtgag cacacagcga     2940

tctaccatct ttcccctgga tggtgtggtg cgcatgctgc tgttcagaga ctgtgaagag     3000

gccaccgact tcctcacctg ccacggcctc accgtttccg acggctgtgt ggagctgaac     3060

cggtctgcat tcctggaacc agagggatta tccaagacca ggaagtcggt gtttattact     3120

aggaagctga cggtgtcagt cggggaaatt gtgaacggag ggccattgcc ccccgtccct     3180

cgtcataccc ctgtgtgcag cttcaactcc cagaacaagt acatcgggga gagcctggcc     3240

gcggagctgc ccgtcagcac ccagagaccc ggctccgaca cagtgggcgg agggagagga     3300

gaggagtgtg gtgtagagcc ggatgcaccc ctgtccagtc tcccacagtc tctaccagcc     3360

cctgcgccct caccagtgcc tctgcctcct gtcctggcac tgaccccgtc tgtggcgccc     3420

agcctcttcc agctgtctgt gcagcctgaa ccaccgcctc cagagcccgt gcccatgtac     3480

tctgacgagg acctggcgca ggtggtggac gagctcatcc aggaggccct gcagagggac     3540

tgtgaggaag ttggctctgc gggtgctgcc tacgcagctg ccgccctggg tgtttctaat     3600

gctgctatgg aggatttgtt aacagctgca accacgggca ttttgaggca cattgcagct     3660

gaagaagtgt ctaaggaaag agagcgaagg gagcaggaga ggcagcgggc tgaagaggaa     3720

aggttgaaac aagagagaga gctggtgtta agtgagctga gccagggcct ggccgtggag     3780

ctgatggaac gcgtgatgat ggagtttgtg agggaaacct gctcccagga gttgaagaat     3840

gcagtagaga cagaccagag ggtccgtgtg gcccgttgct gtgaggatgt ctgtgcccac     3900

ttagtggact tgtttctcgt ggaggaaatc ttccagactg caaaggagac cctccaggag     3960

cttcagtgct tctgcaagta tctacagcgg tggagggaag ctgtcacagc ccgcaagaaa     4020

ctgaggcgcc aaatgcgggc tttccctgct gcgccctgct gcgtggacgt gagcgaccgg     4080

ctgagggcgc tggcgcccag cgcagagtgc cccattgctg aagagaacct ggccaggggc     4140

ctcctggacc tgggccatgc agggagattg ggcatctcct gcaccaggtt aaggcggctc     4200

agaaacaaga cagctcacca gatgaaggtt cagcacttct accagcagct gctgagtgat     4260

gtggcatggg cgtctctgga cctgccatcc ctcgtggctg agcacctccc tgggaggcag     4320

gagcatgtgt tttggaagct ggtgctggtg ttgccggatg tagaggagca gtccccagag     4380

agttgtggca gaattctagc aaattggtta aaagtcaagt tcatgggaga tgaaggctca     4440

gtggatgaca catccagcga tgctggtggg attcagacgc tttcgctttt caactcactt     4500

agcagcaaag gggatcagat gatttctgtt aacgtgtgta taaaggtggc ccatggcgcc     4560

ctcagtgatg gtgccattga tgctgtggag acacagaagg acctcctggg agccagtggg     4620

ctcatgctgc tgcttccccc caaaatgaag agtgaggaca tggcagagga ggacgtgtac     4680

tggctgtcgg ccttgctgca gctcaagcag ctcctgcagg ctaagccctt ccagcctgcg     4740

cttcctctgg tggttcttgt gcctagccca ggaggggacg ccgttgagaa ggaagtagaa     4800

gatggtctga tgctacagga cttggtttca gctaagctga tttcagatta cactgttacc     4860

gagatccctg ataccattaa tgatctacaa ggttcaacta aggttttgca agcagtgcag     4920

tggctggttt cccactgccc ccattccctt gacctctgct gccagactct cattcagtac     4980

gtcgaagacg ggattggcca tgagtttagt ggccgctttt tccatgacag aagagagagg     5040

cgtctgggcg gtcttgcttc tcaggagcct ggcgccatca ttgagctgtt taacagtgtg     5100

ctgcagttcc tggcttctgt ggtgtcctct gaacagctgt gtgacctgtc ctggcctgtc     5160

actgagtttg ctgaggcagg gggcagccgg ctgcttcctc acctgcactg gaatgcccca     5220

gagcacctgg cctggctgaa gcaggctgtg ctcgggttcc agcttccgca gatggacctt     5280

ccacccctgg gggccccctg gctccccgtg tgctccatgg ttgtccagta cgcctcccag     5340

atccccagct cacgccagac acagcctgtc ctccagtccc aggtggagaa cctgctccac     5400

agaacctact gtaggtggaa gagcaagagt ccctccccag tccatggggc aggcccctcg     5460

gtcatggaga tcccatggga tgatcttatc gccttgtgta tcaaccacaa gctgagagac     5520

tggacgcccc cccggcttcc tgttacatca gaggcgctga gtgaagatgg tcagatatgt     5580

gtgtattttt ttaaaaacga tttgaaaaaa tatgatgttc ctttgtcgtg ggaacaagcc     5640

aggttgcaga cgcagaagga gctacagctg agagagggac gtttggcaat aaagcctttt     5700

catccttctg caaacaattt tcccatacca ttgcttcaca tgcaccgtaa ctggaagagg     5760

agcacagagt gtgctcaaga ggggaggatt cccagcacag aggatctgat gcgaggagct     5820

tctgctgagg agctcttggc gcagtgtttg tcgagcagtc tgctgctgga gaaagaagag     5880

aacaagaggt ttgaagatca gcttcagcaa tggttgtctg aagactcagg agcatttacg     5940

gatttaactt cccttcccct ctatcttcct cagactctag tgtctctttc tcacactatt     6000

gaacctgtga tgaaaacatc tgtaactact agcccacaga gtgacatgat gagggagcaa     6060

ctgcagctgt cagaggcgac aggaacgtgt ctaggcgaac gactaaagca cctggaaagg     6120

ctgatccgga gttcaaggga agaggaagtt gcctctgagc tccatctctc tgcgctgcta     6180

gacatggtgg acatttgagc agcctgacct gtggggaggg ggtctctccc gaagagtttc     6240

tgtttttact caaaataatg ttattctcag atgcttgatg cactgttgga aatgtgatta     6300

atttaatcat gcagataaac catttaaatg tca                                  6333


<210> 2488
<211> 1030
<212> DNA
<213> Homo sapiens

<400> 2488
ggagcccgga gctgcagcca ccggggagcc aggtaccttc cgcgagacgt cgaggggcga       60

gtcctagtct cttttctccg cactggaaga cttgaacact tccttctctg gtctctgtca      120

cccaggctgg agtgtagtgg cgcaatctca gctggctgga gccttgacct ccttgggctc      180

aagctatcct cccacctcag cctctcaaat agctgggact acaggcagca aagcacctgc      240

tctgagtggc catggggaag cgatacttct gtgactactg cgaccgctcc ttccaggaca      300

acctccacaa ccgcaagaag cacctgaacg ggctgcagca cctcaaggcc aagaaggtct      360

ggtacgacat gttccgagat gcagctgcca tcttgctgga tgagcagaac aagcggccct      420

gcaggaagtt tctactgaca ggccagtgcg actttggctc caactgcaga ttttcccaca      480

tgtcagagcg agacctgcag gagctgagca tccaggtgga ggaggagagg cgagccaggg      540

agtggctact agatgctcct gagctccccg agggccatct ggaggactgg ctggagaaga      600

gagccaagcg gctgagctca gccccaagta gcagggctga acccatcaga accactgtct      660

tccagtaccc cgtgggctgg ccaccagttc aggagctgcc tccatccctg cgggcacccc      720

cacctggggg gtggcctctg cagcccagag tccagtgggg ctgagcccct tgcccccgac      780

tgacccccac gtggtcactt ttctcatcag tcacaatagg aagccaagcc cggttcctgc      840

tacgccccat ggaggctccg agaccatctg cccagcctca ctgaggctca ggacacggcc      900

acaccaagtg cagccctcgt cctgggtctg caccgggcag ctctcccctc actctcctcc      960

acctgccccc ctgcttctta agaagatggg ggagaaaact tccaaatgtt tataaagaaa     1020

gtctgtcacc                                                            1030


<210> 2489
<211> 410
<212> DNA
<213> Homo sapiens

<400> 2489
cagacatcac catcctcctc cccagtacca gcccagccac acgccaccat gtgccacacc       60

agctgctccc cagcctgcca gccaacctgc tgcatacaca gcccctgcca ggcatcctgc      120

tatgtgcccg tgagctgcca gtcctccgtg tgcatgcccg tgagctgcac gcgcattgtg      180

tgcgtggctc cctcctgcca gccctccgtg tgcgtgcccg tgagctgcag gcccatcata      240

tatgtgactc cctcttgcca atcttcgggg tgctgccagc ccccctgcac cactgccctc      300

tgcagaccca tctcctgcag caccccttcc tgctgctgac cagctgctcc tggtacacgg      360

gggtacacac ctgtatccct ccgtgaataa gcatctggtg gacccccaga                 410


<210> 2490
<211> 1255
<212> DNA
<213> Homo sapiens

<400> 2490
tcacacactc acttacacct cccccagctc acctcctccc caccccagca tggccgcgtc       60

caccatgtcc atccgctcca gcgcttactc cgactcctgg caggtggacg actgcccaga      120

gagctgctgt gagcccccct gctgcgccac cagctgctgc gccccggccc cctgcctgac      180

cctggtctgc accccagtga gccgtgtatc cagcccctgc tgccaggtga cctgtgagcc      240

cagcccctgc caatcaggct gcaccagctc ctgcacgccc tcgtgctgcc agcagtctag      300

ctgccagccg gcttactgca cctcctcccc ctgccagcag gcctgctgcg tgcccgtctg      360

ctgcaagcct gtgtgctgcg tgcccgtctg ctgtggggct tcttcgtgct gccaacagtc      420

tagctaccag ccagcttgct gtgcctcttc ctcctgccag ccggcctgct gtgtgcccgt      480

ctgctgcaaa cctgtgtgct gtgcgcccac ctgctctgag gattcctatt catgctgcca      540

acagtctagc tgccagccag cttgctgcac ttcctccccc tgccagcagt cctactgtgt      600

gcctgtctgc tgtaagcctg tctgctgcaa acccatctgc tgtgtgcctg tctgctctgg      660

ggcttcctct ttgtgctgcc agcagtctgg ctgccagccg gcttgctgca ccacctcctg      720

ctgcagaccc tcctcctctg tgtccctcct ctgccgccct gtgtgcaggc ccgcctgctg      780

cgtgcccgtc tcctcctgct gtgcccccac ctcctcccgc cagcccagct attgccgcca      840

ggcctcctgt gtgtcccttc tctgccgccc tgtgtgctcc cgcccggcct gctacagctt      900

ctcctcaggc cagaagtcca gctgctgacg gtcatgtccc ccagggccag ccgggctcag      960

gccccacctc cctgccagtc cttggacctc ccagcccacc cagcctcagc acagctcaac     1020

acagaaggag cagccccagc cacagccgcc cagccccggg gtctcagatg ctcactggct     1080

cctccctgac ctcccccccg ggcaggcgag ccctggcttc tcctcacggt gcttcctggc     1140

tgcagaccac aaccctccgc tggtcgctgg ttggggacgg gccctcctga cccgggtctc     1200

acccccagca gcgtcaccct ctgcccctga gcaccaataa agcgtctgcg gcccc          1255


<210> 2491
<211> 5817
<212> DNA
<213> Homo sapiens

<400> 2491
ctccgcaccc gctccccgct cgggccgagg cgccgcggcc gcgcgcccct cctggaggag       60

gaggaggaag gaggcgggag gaggagttgc cgagaggaga aggcgagcgc ggcagtcgcg      120

ccggcgctgg gcgaggaagc ggagccgggc cgcctccgga aaatggctcc aaaggttaaa      180

tgaagcagga aaaatacata gatgcagcct tgcagcctct ccagatgttt ggggataata      240

ttccagatag aaatattgat cccttggatt aggtaactag tcataatgaa gaaaattagt      300

cttaaaacct tacggaaatc ttttaacttg aataaaagta aagaagaaac tgatttcatg      360

gtagtacaac aaccatcgct agccagtgac tttggaaaag atgattcctt atttggtagc      420

tgctatggta aagatatggc cagctgcgat atcaacggtg aagatgaaaa aggcggaaaa      480

aacagatcaa aaagcgagag cctgatgggt acgctaaaaa ggcggctttc tgcaaaacag      540

aagtcaaaag gcaaggcggg cacaccctct gggagctctg ccgacgagga caccttctcc      600

tcctcctcag cacccatagt ctttaaagac gtgagagctc agaggccgat aaggtccacg      660

tcgctccgca gccatcacta cagtcccgcg ccgtggcctc tgcggcccac aaactccgag      720

gagacctgca tcaagatgga ggtgagagtc aaggccttgg ttcactcttc cagcccgagt      780

ccagccctga atggcgtccg gaaggatttc cacgacctcc agtctgagac cacgtgccag      840

gagcaagcca attcactgaa gagctcggct tctcataatg gagacctgca tcttcacctg      900

gatgaacatg tgcctgtcgt tattggactt atgcctcagg actacattca gtatactgtg      960

cctttagatg aggggatgta tcctttggaa ggatcacgga gctattgtct ggacagctct     1020

tctcccatgg aagtctctgc ggttcctcct caagtgggag ggcgcgcttt ccccgaggat     1080

gagagtcagg tagaccagga cctagttgtc gccccagaga tcttcgtgga tcagtccgtg     1140

aatggcttgt tgattggcac cacgggagtc atgttgcaga gcccgagagc gggtcacgat     1200

gatgtccctc cactctcacc attgctacct ccaatgcaga ataatcaaat ccaaaggaac     1260

ttcagtggac tcactggcac agaagcccac gtggctgaaa gtatgcgctg tcatttgaat     1320

tttgatccga actctgctcc tggggttgca agagtttatg actcagtgca aagtagtggt     1380

cccatggttg tgacaagcct tacagaggag ctgaaaaaac ttgcaaagca aggatggtac     1440

tggggaccaa tcacacgttg ggaggcagaa gggaagctag caaacgtgcc agatggttct     1500

tttcttgttc gggacagttc tgacgaccgt taccttttaa gcttgagctt tcgctcccat     1560

ggtaaaacac ttcacactag aattgagcac tcaaatggta ggtttagctt ttatgaacag     1620

ccagatgtgg aaggacatac gtccatagtt gatctaattg agcattcaat cagggactct     1680

gaaaatggag ctttttgtta ttcaaggtct cggctgcctg gatctgcaac ttaccccgtc     1740

agactgacca acccagtgtc ccggttcatg caggtgcgct cgttgcagta cctgtgtcgt     1800

tttgttatac gtcagtatac cagaatagac ttaattcaga aactgccttt gccaaacaaa     1860

atgaaggatt atttacagga gaagcactac tgaaagattg agaaccctgc atcttgcact     1920

ttgggaataa gaacaagaga ttgaaataca gtttacaaac tttcattgcc atcaaaatct     1980

tttgctgcca taactatttc agttttatgt gtaaaagagt catcagtttg tttaggggtg     2040

gggaagtgtc agcaaggtgt cttgggttta ttttggttct ttaaaaaagg gaagtcttga     2100

ggttttagag gtgtgaatta tgtttcatca atgtgcagaa taatcacaat gtgaattatc     2160

aaattctcct caatgccccc cccgcccagt cctttgctgc tatccactgt gatttttatg     2220

cattaaaagc acatttcatg tgtattcaac cctaagtaaa gttgaatgaa acttaacaga     2280

atggaaattg ctatgtcttt ttaaatggtc cattttcaaa agacagtgtt gaataaacat     2340

acctgtgtga taaaacacag aatttacata tacactgaag atgagttttt aatctcttac     2400

tttaaaaaga tttatttaga atcgtgaatt gacataatct tgggtaatgg aacggagatc     2460

tgcaacatat cttttaacaa cacttttttc taaattattt ctaaggttgt gctaattctt     2520

ttggttgtga aaagttgaat ttttctgttg ccttcgtttt catcttctag tttgtctatt     2580

ttaataaatg gccttacatt aaaaaattgt aaagaaatgt ataccaccaa tttagaaatt     2640

gttgcctttt ctgtaattaa actcgggtac aaattggcat aacatgaaaa cctatggaac     2700

tagaattatt attaaagaaa tattagatga tcatagcttc ctgtgatagc atttttttgt     2760

gtgttaccta tccttttggt aaaatgtttt atctgtgatt tctttagctt agtcaacatt     2820

ttcttgggtg aacttgattg tcaactaatt ttcataaatg gactggattc tcttgcaaca     2880

ttaatgttta taaaaagttt taaattgatt tgaatagaaa gaaaacattg ttttaaagtt     2940

ggatttatat ttttcttcta tgtagttact ataaaagtgt gctggatttg accaatcctt     3000

acccccacta taaagagaac ccgtgatgac tttagtttaa aaattgtgga aattgtggag     3060

caatttttct cacaatgtga gaaaaattct aaaccatatt agataatgtg gaagtcatat     3120

tgtctatcat atatactgcc atttaaaaat aggtttttaa aatttagcta agtcttaagt     3180

aatttgccgt tgctaataat tttatctcct tgagtcggtt gttggggaga gatgttatat     3240

tcaataattt ttagttattt tgtaatgcag agtgtttatt catttcacag ttctgcaatg     3300

gatgtagtat tttgggattg ccctgtccag aaaattttca gctacacacc tttaaaggaa     3360

aatgtttcta tctcagatga aacatgtaat ttgggatggt tcttcctttg tcacttaaag     3420

gaagagatag gaaaagtctc ttacccactt taaacatgag ggtaaaggtt taggtcaaac     3480

ttactggctt tgtcattcaa gcatatctga atcctcactt ttttctcttt gctttttagg     3540

gtcagaactg agatattacc aagaaaaggc acaatgccat aatattatgg tgttatggta     3600

ttttgactta aaggggaaaa ggtacttaat tttggtggga tgttgattgt accttgttaa     3660

aaagactctc attttctcat atgttttctc ctaataagat ggaatatgga gtatactgta     3720

ataatataag tgttcattat aagctatttg gattaagaac tattgcagag ttgtaagctt     3780

gttatcaaat taatgcaaga catttaaact atttttttgc aaaactattt atttttaaaa     3840

caacttaaag tatatctagg gtgagttaaa agtccctgtg catctatatt agatggcagg     3900

ttttgtcaca gagtcactgt gtattaataa taaatgttga aatggcttct ccgtgtctcc     3960

agaagcattt acatgtcctc cttgtgagat catggtgcac agaggtcttt ggactgccct     4020

gaacccgtct tatgtggaca taacctattc ccttcgtttt ctcatcatgc catgtgttta     4080

agatctaccc gcttagtgtc aagattattg agattttcat ctaaatgttt ttaaaattgt     4140

attttgtgtt ttagtggagg acagtcttga tactgttcta attcagaaag ccaaattttg     4200

atgcgctttt gtatattcat aatatatact ttaatatgcc ctattctaat ctagtttgaa     4260

attgttagat tctgatagta taatgataaa atcaaactat ttgccaaaaa gttaaattta     4320

caagcagaaa gatgttttgc gatattttct acttttgtgt agaaagataa ccatttgggg     4380

taggcagcac aacagaatgt gaaagattgg ctttatatga tactaacaca gtccagttaa     4440

aagtggaaac agggaaaaga gagagagaaa actcatcatt tagtttggtc tagacacaat     4500

ttggttaaat tttaggattc tattggcagt taacatagat gacatggaca cagcctatga     4560

gtgcttttta aatacgtgct tctaaaaatc tgagctcaaa gcaagaaaaa gaaaacagga     4620

aagctgtatc catttgccat aatagatgaa tcagaattgt tttctattaa atatttcatc     4680

acgaaatatg atggaggcca gaagctattt ttaggcttac tataacacta ttatgcattt     4740

ttataaataa gaagaaggct gtagaaagta cttgaaaaat atctaattct ctttctgtct     4800

aaggaaaact ctttctactt ggtgcaataa tctgaaaatt tagaaggtca aaatatgtca     4860

caggaaatga tcatagacct aaaaatagtt tttaaggaaa ccagctacac ggggcaacca     4920

accatcttgc tgttgaagaa aacagttcca aaaggctaaa tcattggcat aaaggaaaca     4980

aaacccaaag tatgcgttgt aattcttgag ccagtattac tgaaacagga taaaagttat     5040

aaaatctaac ataggttaat gcaatgtctc tgctagtgct acaagtctaa aatatctttg     5100

taacaatgct ttcagaaatg ccagttttaa ttacatttca cattgtatat gagagatact     5160

gctttatgaa tgaatcggaa taatacattt tcatttaaat cttaattgct tttcattaaa     5220

tgcgaagtct taatttcaaa atgaaatcac actaccagca atagacagtt ttcttgaaaa     5280

ctctaataag gaacaatagc cagttccgta aataacttta aaattctaaa agtgttggta     5340

cactagcaat cacaaatatg gtttctttta atactttttt aatcctgtaa agaagggttt     5400

ttataaacat tctttttatt aatcagtcat aacatggcga agtgtgtagt tgctgtttct     5460

gaaaagtgat ccaaactcta catccagaga ttatgaaaaa ttcttataga attttgtaac     5520

aagtatttac atgttgggtg aaagaaattt catagtcgtt ggagtgccat gaaattaata     5580

cttgcaattc agattgcggt agtttacact ttttctgtat gtttcaaatc aggtgtgtac     5640

catttgtact gagaacacca cagaatgaat tatccaaagt ccattgattt taatacgtgt     5700

tttggtttgt aaacaaatta tagtaatttc ttgcacattt ttggaaatta attgtataag     5760

aatttatgta tctgcttcta gatacagtgt gtaaataaaa aatttcgttc acaagac        5817


<210> 2492
<211> 3361
<212> DNA
<213> Homo sapiens

<400> 2492
ctgccggact gacgggcggc cgggcggtgc gcggcggcgg tggcggcggg gaagatggcg       60

gcgtcctccc tggaacagaa gctgtcccgc ctggaagcaa agctgaagca ggagaaccgg      120

gaggcccggc ggaggatcga cctcaacctg gatatcagcc cccagcggcc caggcccacc      180

ctgcagctcc cgctggccaa cgatgggggc agccgctcgc catcctcaga gagctccccg      240

cagcacccca cgccccccgc ccggccccgc cacatgctgg ggctcccgtc aaccctgttc      300

acaccccgca gcatggagag cattgagatt gaccagaagc tgcaggagat catgaagcag      360

acgggctacc tgaccatcgg gggccagcgc taccaggcag aaatcaacga cctggagaac      420

ttgggcgaga tgggcagcgg cacctgcggc caggtgtgga agatgcgctt ccggaagacc      480

ggccacgtca ttgccgttaa gcaaatgcgg cgctccggga acaaggagga gaacaagcgc      540

atcctcatgg acctggatgt ggtgctgaag agccacgact gcccctacat cgtgcagtgc      600

tttgggacgt tcatcaccaa cacggacgtc ttcatcgcca tggagctcat gggcacctgc      660

gctgagaagc tcaagaagcg gatgcagggc cccatccccg agcgcattct gggcaagatg      720

acagtggcga ttgtgaaggc gctgtactac ctgaaggaga agcacggtgt catccaccgc      780

gacgtcaagc cctccaacat cctgctggac gagcggggcc agatcaagct ctgcgacttc      840

ggcatcagcg gccgcctggt ggactccaaa gccaagacgc ggagcgccgg ctgtgccgcc      900

tacatggcac ccgagcgcat tgacccccca gaccccacca agccggacta tgacatccgg      960

gccgacgtat ggagcctggg catctcgttg gtggagctgg caacaggaca gtttccctac     1020

aagaactgca agacggactt tgaggtcctc accaaagtcc tacaggaaga gcccccgctt     1080

ctgcccggac acatgggctt ctcgggggac ttccagtcct tcgtcaaaga ctgccttact     1140

aaagatcaca ggaagagacc aaagtataat aagctacttg aacacagctt catcaagcgc     1200

tacgagacgc tggaggtgga cgtggcgtcc tggttcaagg atgtcatggc gaagactgag     1260

tcaccgcgga ctagcggcgt cctgagccag ccccacctgc ccttcttcag gtagctgctt     1320

ggcggcggcc agccccacag ggggccaggg gcatggccac aggcccccct ccccacttgg     1380

ccacccagct gcctgccagg ggagacctgg gacctggacg gccacctagg actgaggaca     1440

gagagtgggg ggtgcccacc cacccccccc gccccgggcc taccaagccc ccgcccttcc     1500

caccccgggg tcagccggcc gtgtgcgtcc cccgacagac actgtgaacg gaagacagca     1560

ggccgcgatc agagtcgctg ttcattcagc cgcagcctct gggccggggc ggcccccagg     1620

ggccaggaga gagccctgga gtcccgcagc caccatgcac gctcccagcg tgctgtgtcc     1680

ttcgccactc ccacgcgccc gttcctcttc cgtcgccctc tgtcccctgc tctacctctc     1740

tgtccttgtc tggctctccc gtcaccctcc ctgcctctgt ctctcttctg gcctgagcct     1800

gggcccagcc acctcctgac gggtcccctg ggtctgcata ggtctcccat ggcgcaatga     1860

gtcagtggcc cccagccagg cagtgtgggc attgccactg cggctggacg gggctgcgcg     1920

ctcgcgctct ctctctctct ctctctctct ctttgatctc agggggtcct ttttggagtt     1980

tattgtattt tattgtactt ggtggggtgt ttggggtggg ggcggaggag agcttgttct     2040

cgtggggttg tcggtacctt cagaaacttt taccaaagtc acgattagct gcttgtggtg     2100

gggccccaac cgccctcggg cactggggag ctgggctggg gctgctgctc tggggtctcc     2160

gggggccaca gcttggggtg agttgaagac ctcaggggat gtggaggggt ctgcggggcc     2220

ctggccgcac aggatggcct tcagggaagg tggtcttggg gcatggtgca gagcaggtga     2280

ccggagggaa tcggtgacgg agcggggcca agggaggggt ccggagggag tcagggatgg     2340

agggcagagg gagtggatgt gggggtttga ggacgtgtga caagctccag caggggtggg     2400

ggccgggctg agggtggggg tgcgaggtgg tcactcccat cgtgcccctg gccgtccctc     2460

cactcaccca cacctggccc agtccacgtt gaggtccagg actgggaagg accgggtgag     2520

tgcaccgggg acccaggcca ggtgcccccc ggagcctgct ggggtggcca gagcaggagg     2580

gggtgtgttt cctttttgtg ggtgttgcat gcaaatcaag tggacaagaa aaaataacaa     2640

aacaaaaaac aagaaaaaaa aaacacaaaa ccccgtaaaa tcacaaagaa aatccaacac     2700

caaaggcgca gaagccggct ggccgtggtg ggggcagcgt aggcgtagca tccctctcct     2760

ctcacttagc ctgttgactc ttgttattat catgatattc acaaaacgcc gcatgtttaa     2820

aaagtcatag atgtcatctt ctctctgccc ccagggagga aagccacctt ctcttgcccc     2880

ttggcccctt tgtcaggggc caggggtctg ccgggtgggg gtgccaacag gcctggccct     2940

ttcctcccct gcatccagcc atgggggcct ctgcgattgc cggaaggttg catggctggt     3000

cccagggcca gcacaggccc gaggccgggc tgcctggttt tatttttatt taactttatt     3060

ttctgtttta tgagtgtgtg tccgcccacc cccaccccct tcagtgttaa gtggggagcc     3120

ctgggggagt ctctcctgcc tcccagcctc tcccaagacc tcccccctcg tcaccagcca     3180

tccctctgga ccaggcagag ggcggaccgg gtgggcaggg gcctgagggt ggctcgggcc     3240

agcccaccag ccaatggacc cctcctcagg ccgccagtgt cgccctgccc ctttttaaaa     3300

caaaatgccc tcgtttgtaa acccttagac gcttgagaat aaaccccttc cttttcttcc     3360

a                                                                     3361


<210> 2493
<211> 2224
<212> DNA
<213> Homo sapiens

<400> 2493
agaccagaaa cggaagagag cgcgggggat gtgtttggcg tggggcgcac tgttcagttg       60

ctctcctgga tggctttatg tctccgcggt gtttcctaga gtctcggcgt ttctacctct      120

tcgcaccctt tcctgccacc ctttgtcccc tggaagcccg gagacatcag cggctgcaat      180

tttgctactc gctgctcggc gtggaactgt caggacaaaa aataatatcc aaagatattt      240

tggcactaac ggcgctatct gtagcaagaa agttgagcag tgtgaactgt tgagacttcc      300

aaggagactt cagacaacca agacagtgta aaggaaaaca gagaaaaaga cttgttagac      360

attattaagg gcacgaaagt tgaattgagc acagtaaatg tacaaacaac aaagccaccc      420

aacagaagtt cacttaaaag ctacaactgg cgggcctcaa agagctttag gacatgctcc      480

aaagaagaga aatgagcccc tgagtcctga gttggtggca gctgcatctg ctgctctgtt      540

ttgacaagca aacaagccag aactgctcag gcagctccgt agcatgagga agagtcaggg      600

gcacagagag atggagagag acctagttag gaaaaatata ttcaggggga agagatgtaa      660

tagatttcac attatggcag ttactaaaga agcacgtgaa cagacacatc accttcactt      720

tgggatatgg aatttgataa gcagttagcc acagaatatg aacaacccct tgagaatgag      780

attgaagaac tgatccaggg gacaaaagag gggaaactga gagttcccaa ttaataatga      840

agcagcttca tatctaagat ctctggtgga ctttttctgc ccgtggacgc cgctgaagaa      900

gcatcgttaa agtctctctt caccttgccg tcatgtctaa gtcagcgtct ccaaaagagc      960

ccgaacagct gaggaagctc ttcattggag ggttgagctt tgaaacaact gatgagagcc     1020

tgaggagcca ttttgagcaa tggggaacgc tcacagactg tgtggtaatg agagatccaa     1080

acaccaagcg ctccaggggc tttgggtttg tcacatatgc cactgtggag gaggtggatg     1140

cagctatgaa tacaacgcca cacaaggtgg atggaagagt tgtggaacca aagagagctg     1200

tctccagaga agattctcaa agaccaggtg cccacttaac tgtgaaaaag atatttgttg     1260

gtggcattaa agaagacact gaagaacatc acctaagaga ttattttgaa cagtatggaa     1320

aaattgaagt aattgaaatc atgactgacc gaggcagtgg caagaaaagg ggctttgcct     1380

ttgtaacctt tgacgaccat gactccgtgg ataagattgt cattcagaaa taccatactg     1440

tgaagggcca caactgtgaa gttagaaaag ccctgccaaa gcaagagatg gctagtgctt     1500

catccagcca aagaggtcga aggggttctg gaaactttgg tggtggtcgt ggagatggtt     1560

tcggtgggaa tgacaacttt ggtcgtggag gaaacttcag tggtcgtggt ggctttggtg     1620

gcagctgtgg tggtggtgga tatggtggca gtggggatgg ctataatgga tttggtaatg     1680

atggaagcaa ttttggaggt ggtggaagct acaatgattt tggcaattac aacaatcagt     1740

cttcaaattt tggacccatg aagggaggaa attttggagg cagaagctct ggcccctatg     1800

gcggtggagg ccaatacttt gcaaaaccac aaaaccaagg tggctatggc gtttccagca     1860

gcagcagtag ctatggcagt ggcagaagat tttaattagg aaacaaagct tagcaggaga     1920

ggagagccag agaagtgaca gggaagctac aggttacaac agatttgtga actcagccaa     1980

gcacagtggt ggcagggcct agctgctaca aagaagacat gttttagaca aatactcatg     2040

tgtatgggca aaaaactcga ggactgtatt tgtgactaat tgtataacag gttattttag     2100

tttctgttct gtggaaagtg taaagcattc caacaaagtg ttttaatgta gatttttttt     2160

tttgcaccca tgctgttgat tgctaaatgt aatagtctga ttgtgacgct gaataaatgt     2220

ctct                                                                  2224


<210> 2494
<211> 2202
<212> DNA
<213> Homo sapiens

<400> 2494
cagggcactg aggagggagt tgcgcgcgcg aggcgagggc gatggggcca agaagaaccg       60

gggcgatagc gcggcagcgg tgacagctgg gacccgccgc ggtcgggctg ccccctcccc      120

tcgccccgac cgctcccctg ctggtgaggg cctgcggagg cggcggcggc ggcgcccttg      180

gtggcagtgg tggcggcgga gcagcctccc gggatcgtgt ccggagctcg aggagagggt      240

ggtgcccggc gagctatgca cgggggcggc ggcgtctcct cctgttccgc ctcctcagtc      300

tcctcggtct cgcagaatcc gccggcggcg gcggcgccag gacatggagc tcgagaacat      360

cgtggccaac tcgctgctgc tgaaagcgcg tcaaggagga tatggcaaaa aaagtggtcg      420

tagtaaaaaa tggaaggaga tactgacact gcctcctgtc agccagtgca gtgagcttag      480

acattccatt gaaaaggatt atagcagtct ttgtgacaag caaccgatag gaagacgtct      540

cttcaggcag ttctgtgata ccaaacccac tctaaagagg cacattgaat tcttggatgc      600

agtggcagaa tatgaagttg ccgatgatga ggaccgaagt gattgtggac tgtcaatctt      660

agatagattc ttcaatgata agttggcagc ccctttacca gaaatacctc cagatgttgt      720

gacagaatgt agattgggac tgaaggagga gaacccttcc aaaaaagcct ttgaggaatg      780

tactagagtt gcccataact acctaagagg ggaaccattt gaagaatacc aagaaagctc      840

atatttttct cagtttttac aatggaaatg gctggaaagg caacccgtaa caaagaacac      900

atttagacat tacagagttc taggaaaagg cggatttgga gaggtttgcg cctgtcaagt      960

gcgagccaca ggaaaaatgt atgcctgcaa aaagctacaa aaaaaaagaa taaagaagag     1020

gaaaggtgaa gctatggctc taaatgagaa aagaattctg gagaaagtgc aaagtagatt     1080

cgtagttagt ttagcctacg cttatgaaac caaagatgcc ttgtgcttgg tgctcaccat     1140

tatgaatgga ggggatttga agtttcacat ttacaacctg ggcaatcccg gctttgatga     1200

gcagagagcc gttttctatg ctgcagagct gtgttgcggc ttggaagatt tacagaggga     1260

aagaattgta tacagagact tgaagcctga gaatattctc cttgatgatc gtggacacat     1320

ccggatttca gacctcggtt tggccacaga gatcccagaa ggacagaggg ttcgaggaag     1380

agttggaaca gtcggctaca tggcacctga agttgtcaat aatgaaaagt atacgtttag     1440

tcccgattgg tggggacttg gctgtctgat ctatgaaatg attcagggac attctccatt     1500

caaaaaatac aaagagaaag tcaaatggga ggaggtcgat caaagaatca agaatgatac     1560

cgaggagtat tctgagaagt tttcagagga tgccaaatct atctgcagga tgttactcac     1620

caagaatcca agcaagcggc tgggctgcag gggcgaggga gcggctgggg tgaagcagca     1680

ccccgtgttc aaggacatca acttcaggag gctggaggca aacatgctgg agcccccttt     1740

ctgtcctgat cctcatgccg tttactgtaa ggacgtcctg gatatcgagc agttctcggt     1800

ggtgaaaggg atctacctgg acaccgcaga tgaagacttc tatgctcggt ttgctaccgg     1860

gtgtgtctcc atcccctggc agaatgagat gatcgaatct gggtgtttca aagacatcaa     1920

caaaagtgaa agtgaggaag ctttgccatt agatctagac aagaacatac ataccccggt     1980

ttccagacca aacagaggct tcttctatag actcttcaga agagggggct gcctgaccat     2040

ggtccccagt gagaaggaag tggaacccaa gcaatgctga gcaccccggt gcggaccaca     2100

gagcagaccc tggcgccagg aaggagcatg tgttagcgtc tcgtcccacc tggaattgta     2160

ataaatacat ctaaataaaa catgccttgg gagtgtacag ac                        2202


<210> 2495
<211> 3379
<212> DNA
<213> Homo sapiens

<400> 2495
agccggccta caagcttccc ccgcccctga gctgtttaaa tatgctaatg aaaggatagg       60

gcctgaccag tagaacggcg aggcggtgta tcacgtggct cggggacgtg tcaggggcgg      120

agcctccgca gcccctgccc gagttaaaac cggagtgtga gagagaaaag cgcttcagta      180

gcgagagggg ctgagaaagt ggtgacaccg ccgggacacg tctgcctcta tgaaccagcg      240

cagccatctg ggcaccacct acctggacac ggccaaaggc gcggtagaga ccttcatgaa      300

gctccgtgcc cgggaccctg ccagcagagg agacaggtat atgctggtca ctttcgaaga      360

gccgccctat gctatcaagg ctggatggaa agaaaaccat gcaacgttta tgaatgaatt      420

gaaaaacctt caggctgaag gacttacgac tcttggccaa tccctaagga cagcttttga      480

tttattaaat ttaaatagat tagtaactgg catagacaac tatgggcagg gaagaaaccc      540

ttttttcttg gagccagcaa taattatcac aattactgat gggagcaagt tgactaccac      600

cagtggagtc caggatgagc ttcatttacc tcttaattct cctttgcctg gaagtgaatt      660

gaccaaggaa ccttttcgtt gggatcagag actctttgca ttagtgttgc ggttgcctgg      720

caccatgtca gtagaatcag aacagttgac aggtgtgcct ttagatgact ctgcaatcac      780

accaatgtgt gaagtgacag gcggccgttc atattctgtg tgttctccaa gaatgcttaa      840

tcagtgtctg gagtccttgg tgcagaaagt acaaagtggg gtggtaataa actttgaaaa      900

agcaggacca gatccttccc ctgtagaaga tgggcagcca gatatatcaa ggccttttgg      960

atctcagcct tggcatagct gtcacaaact catatatgtc agaccaaatc ctaaaactgg     1020

ggttcctata ggtcattggc ctgttccaga gtctttttgg ccagatcaaa attcgccaac     1080

actaccacct cgtacatctc atcctgtagt gaagttttcc tgtacagact gtgaaccaat     1140

ggttattgat aaacttcctt ttgacaaata tgagttggaa ccttcaccac tgactcaatt     1200

tatcctggaa aggaaatctc ctcaaacatg ttggcaggtg tacgtgagca atagtgcaaa     1260

atacagtgaa cttggtcatc cttttggtta cttgaaagcc agtacagcac tgaactgtgt     1320

caacttattt gtgatgcctt acaattatcc agtccttctt cccctcttag atgacttgtt     1380

taaagtgcat aaagcaaaac caacattgaa gtggagacag tcatttgaaa gttatttgaa     1440

gacaatgcct ccctactatc ttgggccctt gaagaaagct gttaggatga tgggagcacc     1500

taacctaata gcagacagta tggaatatgg acttagttac agtgtcattt catacctcaa     1560

aaaactgagt caacaggcca aaatagaatc tgatcgagtc attggatctg taggcaaaaa     1620

agtagtacag gagactggaa taaaagtccg gagccgatca catggtttat caatggcata     1680

taggaaagat tttcaacaac tcctccaggg aatttcagag gatgtccctc acagactgct     1740

agaccttaat atgaaggaat acactgggtt ccaagttgct ttgctgaata aggatttgaa     1800

gccacagaca tttagaaatg cttatgacat accaagacga aatcttttgg atcacttaac     1860

aagaatgaga tctaatcttt tgaagagcac tcgcagattt ctgaaaggac aggacgaaga     1920

tcaagtgcac agtgttccta tagcacaaat ggggaactac caggaatacc tcaagcaagt     1980

accttctcca ctaagagaac ttgatcctga tcagccacga aggttgcata catttggcaa     2040

cccctttaag ctggataaga agggtatgat gatagatgaa gcagatgaat ttgtggctgg     2100

acctcaaaat aaacataaac gacccggaga accaaatatg caagggatcc ctaaaagacg     2160

tcggtgtatg tctccactac taagaggcag acagcagaat cctgttgtaa acaatcatat     2220

tgggggaaaa ggaccacctg cacctacaac tcaagcacag ccagatctta ttaaacctct     2280

tcctcttcat aaaatttcag aaaccactaa tgattcgata atacatgatg tggttgaaaa     2340

tcatgttgca gaccaacttt catcagacat tacaccaaat gctatggata cggaattttc     2400

agcatcttct ccagccagtt tactggaacg gccaaccaat catatggagg ctcttggtca     2460

tgaccattta ggaaccaatg acctcactgt tggtggattt ttagaaaatc atgaggagcc     2520

aagagataaa gaacaatgtg ctgaagagaa cataccagca tcttcactca acaaaggaaa     2580

gaaattgatg cattgcagaa gccatgaaga ggtcaatact gaactaaaag cacaaataat     2640

gaaagagatc cgaaagccag gaagaaaata tgaaagaatc ttcactttac tgaagcatgt     2700

gcaaggcagt ttacaaacaa gactaatatt tttacaaaat gtcattaaag aagcatcaag     2760

gtttaaaaaa cgaatgctaa tagaacaact ggagaacttc ttggatgaaa ttcatcgaag     2820

agccaatcag atcaaccata ttaatagcaa ttaaaagaaa atagaatgtg gccacttatt     2880

tcactatctt cttcaaatac aaagtaaata caagactgtt gtgatcttgc attcattttc     2940

tgacatgcat tgttggctat ttgaaatact aaaagcaaat ctacagatcc tttttccatc     3000

attttacagt gaccttttct tcattttggt ttatttttgt aatgtgaaaa gtatcactct     3060

aaaaaacatt tttaatttaa caaactaaaa atattcctcc aaatctcttg cttgtcattg     3120

actcttgcgt gtcaatttcc ctcaggttct attttcttaa accaaccttt aaaattgtca     3180

cctctgttaa ggttgaactt tgccaaaaaa aaaagaagtt actttgtaat ttttggggaa     3240

aaaagcacat acattaaaac taggtaatgt tttgtatata cagttatttt ggatatatta     3300

ttgtaagttg tacaaatgta ttttgaagaa tatttaagaa aagcactttt gttattccat     3360

caataaatgc tctatttta                                                  3379


<210> 2496
<211> 2734
<212> DNA
<213> Homo sapiens

<400> 2496
aactgttgtg gctgccgcat tgctcccgcc gggctgtagc tgagcgcgga gcccgtgggg       60

accggtgagg ctggctgctg gctctaccag gttctgtgct ggcatcctga gcactgccag      120

gcacttgacc attgagcaga agatggcaga ctactcaaac aaactctact atcagttaga      180

gcaagaaaca gggatccaaa caggttacac aaggacaggc tcaatctttc tggcccaaac      240

tcaggaccga ctgatctccc tgaagcgcat caacgcaggg ctgaatgtta taggtatccc      300

ttctgagatc atctccccca agaaagtggc cgagcttcac catctcctca acgtgcacga      360

cctggtgggg gccatgcatg ttcccgagga tgcagtggtg tcttccgctg acgtggctct      420

tgccctggca agtgctgcct cccaaaatgg tgttcagatc tatgaccgga catctgttct      480

tcatgtaatg gtcaaaaaag gtcaagttac tggagtggag accgataaag gacagattga      540

atgccagtat tttgtcaact gtgctggcca gtgggcatac gagctgggtc tgtccaacga      600

ggagccggtt agtatcccgc tacatgcctg cgaacacttc tacctcctga ctcgcccctt      660

ggagacccct ctgcagagca gcacaccaac tattgtggat gctgatggaa gaatttatat      720

tcggaactgg cagggtggca tcctgtctgg gggctttgag aagaacccga aaccaatttt      780

cactgagggc aagaaccagc tggagattca gaatctacag gaagactggg atcactttga      840

gcctctgttg agttcccttc tgaggaggat gccagaatta gagactctgg agatcatgaa      900

gttggtgaac tgcccagaga ccttcacacc agacatgagg tgcatcatgg gcgagtctcc      960

tgcagtgcag ggctactttg tcctggcagg aatgaactct gctggccttt catttggtgg     1020

aggagccgga aagtaccttg ccgaatggat ggtacatggt tatccctcag aaaacgtttg     1080

ggaattggac ctgaaacgtt ttggagccct ccagagcagc cgcacctttc tgcgccaccg     1140

ggtcatggaa gtcatgcctt tgatgtatga tctgaaggtt ccccgctggg acttccagac     1200

cggtaggcag ttacgcacct ctcctctcta cgaccggctg gatgcacagg gagccaggtg     1260

gatggagaaa catggatttg agaggccaaa gtactttgtt ccccccgaca aggacctcct     1320

ggcattggag cagagcaaga ctttctataa gccagattgg tttgacatcg tggagtctga     1380

agtcaagtgc tgtaaggaag ctgtgtgtgt cattgacatg tcctctttca caaagtttga     1440

gataacatcc actggggatc aggcattaga agttctacag tacctcttct ccaatgacct     1500

ggatgtgcct gtgggccaca ttgtgcatac tggcatgctc aacgagggtg gagggtatga     1560

aaatgactgc agcatagcac gactgaacaa gcgcagtttc ttcatgatct ctccaaccga     1620

ccagcaggtc cactgttggg cctggcttaa gaaacacatg ccgaaagaca gcaacctgct     1680

cctggaggac gtcacctgga agtacacagc cctcaatctg attggccctc gagctgtgga     1740

tgtgctgtct gagttgtcct atgcccctat gactccagac cacttcccaa gcctcttttg     1800

caaggagatg agtgtgggct atgcaaatgg gatccgggtg atgagcatga cgcacacagg     1860

agagccagga ttcatgctct acatccccat agagtacgcc ctgcatgtat acaatgaagt     1920

gatgagtgtt ggccagaaat acggaatccg gaatgctggg tattacgctc ttcgcagtct     1980

ccgaattgag aagttttttg ccttctgggg tcaggatata aataacctca ccacgcccct     2040

ggaatgtgga cgagagtctc gggtgaaatt agagaagggc atggatttca ttggtcgcga     2100

cgccctcctg cagcagaagc agaatggagt gtataaacgc ctcaccatgt tcatcctgga     2160

cgaccatgat tcagacctag acctttggcc ttggtgggga gagcccattt accggaatgg     2220

gcagtatgtt ggcaagacca ccagcagtgc ctacagctac agcctggagc gccacgtttg     2280

cctgggcttt gtgcacaatt tttctgagga cacgggggaa gagcaagtgg tgacagcaga     2340

tttcatcaac cggggagagt atgagattga catcgcggga taccgcttcc aggccaaggc     2400

caagctctac cctgtcgcct ccctcttcac ccagaagcgc cgaaaggatg acatggagct     2460

gagtgactta catgggaagt gatgccacca gggcagcctc acctcctccc catcatcttg     2520

tcctagagtg ggcgtcacct tggagcttct cttccttccg cctctgttcc tcttctggag     2580

cctttgcctc ccatctctta tctccttgat ataattttga acttgaccta ctttaaactt     2640

ttttgctctg cagccttcct tgcccttcca cctcctcctc ctaatattca ctctgggctc     2700

ttcttccctt cccacccctc actcagcttc tcgt                                 2734


<210> 2497
<211> 3998
<212> DNA
<213> Homo sapiens

<400> 2497
cctgcgagat tctgtgcccc ttgtcgggcc gcttgtttgg ctgctgccgt cacctcatgg       60

cgacgcgggt agaggaggca gcgcggggaa gaggcggcgg cgccgaagag gcgactgagg      120

ccggacgggg cggacggcga cgcagcccgc ggcagaagct ggaggagagc aggagtgttc      180

agaagcaaat gaagatcctg cagaagaagc aagcccagat tgtgaaagag aaagttcact      240

tgcagagtga acatagcaag gctatcttgg caagaagcaa gctagaatct ctttgcagag      300

aacttcagcg tcacaataag acgttaaagg aggaaaatat gcagcaggca cgagaggaag      360

aagaacgacg taaagaagca actgcacatt tccagattac cttaaatgaa attcaagccc      420

agctggagca gcatgacatc cacaacgcca aactccgaca ggaaaacatt gagctggggg      480

agaagctaaa gaagctcatc gaacagtacg cactgaggga agagcacatt gataaggtgt      540

tcaaacataa ggaactgcaa cagcagctcg tggatgccaa actgcagcaa acgacacaac      600

tgataaaaga agctgatgaa aaacatcaga gagagagaga gtttttatta aaagaagcga      660

cagaatcgag gcacaaatac gaacaaatga aacagcaaga agtacaacta aaacagcagc      720

tttctcttta tatggataag tttgaagaat tccagactac catggcaaaa agcaatgaac      780

tgtttacaac cttcagacag gaaatggaaa agatgacaaa gaaaattaaa aaactggaaa      840

aagaaacaat aatttggcgt accaaatggg aaaacaataa taaagcactt ctgcaaatgg      900

ctgaagagaa aacagtccgt gataaagagt acaaggccct tcaaataaaa ctggaacggt      960

tagagaagct gtgcagggct cttcagacag aaaggaatga gctcaatgag aaggtggaag     1020

tcctgaaaga gcaggtatcc atcaaagcgg ccatcaaagc ggcgaacagg gatttagcaa     1080

cacctgtgat gcagccctgt actgccctgg attctcacaa ggagctgaac acttcctcga     1140

aaagagccct gggagcgcac ctggaggctg agcccaagag tcagagaagc gctgtgcaaa     1200

agcccccgtc cacaggctct gctccggcca tcgagtcggt tgactaagat gaggtgtgat     1260

cactgtattg agagatatat tttgtgtata actttctctg ttagtagtta actattggtt     1320

ttgtggtgaa aattttctta ctttttctac catatctgta ttttcttaga actactggac     1380

ttatgtggta caggaggctg cttagcagtt ttgaatagtt taatctataa attttcctca     1440

gctgtgttgc acatcagcct cgttctccct ccactggaat gcatgtgttc attgccttgt     1500

cctttctctc cctgctcctt gcacattatc atcctaatga aaatttcact gacagggccg     1560

accattacaa gggaactttg ttctgacgat ggttccttga tgtgaaaaca atattaattt     1620

aaacgtctta gccccccccc ccataatatt attcagaaaa acaaaatacc aaggcgatta     1680

gttttgtcta ataacccatt taaatgccaa gtaaaaataa aactcctagt gttgggtcag     1740

aagcatattt gattgaaatt agctttttga aaacatttat atctcgggac aaattgagat     1800

ggccacatgc ctagaatcct aagtttcggc agaatatgta tataaagatg tcacttgtgg     1860

acaaaatagt acatagaggc aaatcactag acaaataagc ttagtgttta cgtgactgaa     1920

cagtcatcct gctttggttt caggtgtggg atttggacca tgaggggctc ccgtagagga     1980

tggcggtttg tgtttgattc tgatttggga tttcagtaca tattctccac ttcccataga     2040

aggccactta ttctttgaaa actggtgttc atgtttgccg ttcaatgaag tcccttgtca     2100

aagacaagga cggtcaattc acgtgtcact ttcactaggc agaagtttct ccaatacctt     2160

ctggctactt gaaagttact acaaaaattc caccagcaaa gtactccagg tttttcaaaa     2220

gggaattttc attatggatc agtaccaacc gaaattgatt ttcatttcca aaacaaacac     2280

tggcaccaac atttttactt tgggaagact tggcagagtg ttagtcatga tctgttactt     2340

acgtgttcag tctgttttct cacccccttc ttagttacca tctctttttt aagaagaaaa     2400

aagaaaagcc acagtattat caaggtctct acacttggac tgggggaaaa tttgaaatta     2460

agcacataac ttttgaatta gttctttgtt tcaatgttga atgtggcgca gttatgcaga     2520

tgattaatca ggctgcactg atggaagttt tgactttgtc cctggtataa tttgcattga     2580

aatgctttat gaaataaaag gttctactag aactgatgtt agcacattcc actgagcaaa     2640

actatcagac tgacacttgt taaattgctt actggactga ataaactctg ttttgtccag     2700

ttaaaagggt tttctctttg ttacaagtgt tatttgtaaa gtcctgtcac attcatggtc     2760

gaaactgggt tgaaagaatt gaaaattgtc caacagatag atagatagga aaccgcctgg     2820

agtggaggag ggttgtatct aagcctccac tatcagtcat gttaattcaa ggggccacag     2880

tggaggaaaa taaatccaca aagtagatta tctaattacc atcaaaatga gtcagaagca     2940

aaaaacacca ccctccaaca gcctcttagg agtacaccct gttctgctac taaaatacta     3000

gactcatttc cctggtggtg ggggggaatg caggtataga tcagaaatat aatccacctt     3060

aaaattagta ctaatgatca cattatttca caagaactct gctggatgta cagctcttaa     3120

cattttatta agccatttgt gtagcccacc acgtttcttt gtggtgcttg tcctgtgtgg     3180

aagattgtaa atcttgggcc tgttgcatac ttccaagggc tttaaagcaa tgtgattaac     3240

agtacttggc ctgctgcttt tggcttactt tgtattttta gctagatgct attatagtgt     3300

tgaaaggata tggattctgt ctgggatgca tttgttgtcc tttcagaacc cttcctccca     3360

ttaccctgtg aataaaaaca aatgggaccc cctgagaagg acatcttcct acagtgatca     3420

cctcaccagc ccagtgttgt ggctttgtag cgcaccccgt atctaccata ttctagaaca     3480

ctgtaatgct actaggctgg cccagaaaag gtttaaatgt tgaattcact taaattgcaa     3540

ttgttgcacc atcatggaat cgtgatgtgt attatttata ttggcggtgg actccaaggt     3600

gtagagaaaa cttgggtctt gggtaatatg gaccatttca tcctcagact tgttaggagt     3660

acatttcttg gtcttgagac cagtattttt cagttatgta tgcaactgcc tttattacac     3720

ctggttatca caattcaatt ctcaggtgtt gcagaaaaat ctacctcttt cagactgtag     3780

atggaaataa ctgtgaaaaa aatgatgcag atatcttcta gtttgtgcta aacacactgc     3840

tttattttta cagcccacgt ctttcatgag gatacgaatt gttaagaggc agtctcgttt     3900

tgcttttcaa agacattttg tagagatttt tcactaatgt gaatctgatt ttatctactt     3960

gattctgtat agattaagta aatatgtatg ataaactt                             3998


<210> 2498
<211> 2100
<212> DNA
<213> Homo sapiens

<400> 2498
ggctgctggg ctggcggggc gcaggccgcg ggacccgagc ccggggaagc gagagagcgg       60

aggcgccgag gatccgattc actccctggg gagacctatg ggccgaagcc gtgtaaatgc      120

gttttaagag gcctcggctc cgcaactgcc actcctcctc ggggtgttgc acaagtttcg      180

aggtcaccgg cgaccccccc tagcagcgcg cctggctctg gcccccgcga aggaggacgg      240

agtttgtgtg ttgcatactt tctaaggcgg cggctgcagc agcggctcca tccagcccgt      300

cagctcctcc tgcaaggcat ggctggctac ctgagtgaat cggactttgt gatggtggag      360

gagggcttca gtacccgaga cctgctgaag gaactcactc tgggggcctc acaggccacc      420

acggacgagg tagctgcctt cttcgtggct gacctgggtg ccatagtgag gaagcacttt      480

tgctttctga agtgcctgcc acgagtccgg cccttttatg ctgtcaagtg caacagcagc      540

ccaggtgtgc tgaaggttct ggcccagctg gggctgggct ttagctgtgc caacaaggca      600

gagatggagt tggtccagca tattggaatc cctgccagta agatcatctg cgccaacccc      660

tgtaagcaaa ttgcacagat caaatatgct gccaagcatg ggatccagct gctgagcttt      720

gacaatgaga tggagctggc aaaggtggta aagagccacc ccagtgccaa gatggttctg      780

tgcattgcta ccgatgactc ccactccctg agctgcctga gcctaaagtt tggagtgtca      840

ctgaaatcct gcagacacct gcttgaaaat gcgaagaagc accatgtgga ggtggtgggt      900

gtgagttttc acattggcag tggctgtcct gaccctcagg cctatgctca gtccatcgca      960

gacgcccggc tcgtgtttga aatgggcacc gagctgggtc acaagatgca cgttctggac     1020

cttggtggtg gcttccctgg cacagaaggg gccaaagtga gatttgaaga gattgcttcc     1080

gtgatcaact cagccttgga cctgtacttc ccagagggct gtggcgtgga catctttgct     1140

gagctggggc gctactacgt gacctcggcc ttcactgtgg cagtcagcat cattgccaag     1200

aaggaggttc tgctagacca gcctggcagg gaggccccac taccaccccc tcacattgct     1260

acttgtgctg cctctgaacc ctcccctcct gcagaggaaa atggttccac ctccaagacc     1320

atcgtgtacc accttgatga gggcgtgtat gggatcttca actcagtcct gtttgacaac     1380

atctgcccta cccccatcct gcagaagaaa ccatccacgg agcagcccct gtacagcagc     1440

agcctgtggg gcccggcggt tgatggctgt gattgcgtgg ctgagggcct gtggctgccg     1500

caactacacg taggggactg gctggtcttt gacaacatgg gcgcctacac tgtgggcatg     1560

ggttccccct tttgggggac ccaggcctgc cacatcacct atgccatgtc ccgggtggcc     1620

tgggaagcgc tgcgaaggca gctgatggct gcagaacagg aggatgacgt ggagggtgtg     1680

tgcaagcctc tgtcctgcgg ctgggagatc acagacaccc tgtgcgtggg ccctgtcttc     1740

accccagcga gcatcatgtg agtgggcctc gttccccccg gagaatccca gcggggcctc     1800

agagatgcat ctgggagagg tggggaagat ggcaggcaag ggtacccttg gccaggactc     1860

tggtgcccac cctgccaccc ccgcgctcca cctgcagtgt ttctgccctg taaataggac     1920

cagtcttaca ctcgctgtag ttcaagtatg caacataaat cctgttcctt ccagctgtgt     1980

ctgcctcctc tgcagtgcaa ggggcctggt cagccaggtg tgggggtgtt cttggggtct     2040

cctttggtct ccttcccacc tttgtaaata taatgcaaat aaataaatat ttaggttttt     2100


<210> 2499
<211> 3824
<212> DNA
<213> Homo sapiens

<400> 2499
gcttttgctc ggacctggag taatgagagt ggacgtttga ttccaacagg atggcccatt       60

tctccagcga ggaccaggcg atgctgcagg cgatgctgag gcggttgttc cagagcgtga      120

aggagaaaat cacgggtgcc ccttccctgg agtgtgccga agagattctt ttacatctgg      180

aggaaactga tgaaaatttt cacaactatg aatttgtgaa atacctcagg cagcatatag      240

gcaacacttt gggttctatg attgaagaag aaatggaaaa atgcacatct gatcggaatc      300

agggtgaaga atgcggctat gatacagttg tacagcaggt cactaaaaga actcaagaat      360

ctaaagagta caaagaaatg atgcattacc tgaagaacat tatgatagct gtggtcgagt      420

ctatgattaa caagtttgaa gaagatgaga cacgaaatca agaaaggcag aaaaaaatcc      480

aaaaggagaa aagccatagt taccgcacag acaattgctc tgatagtgat tcatcattga      540

atcagagtta caaattttgt caaggaaaat tacaattgat tttagaccag ttggatcctg      600

ggcaacctaa agaggtgaga tatgaagcct tgcaaacatt atgttcagct cctccatctg      660

atgtcctcaa ctgtgaaaat tggactactc tctgcgaaaa actgaccgtg tctctttcag      720

atcctgatcc tgtgtttagt gaccggattt taaaattctg tgcacagaca tttttgcttt      780

ctccattaca tatgaccaag gaaatttata caagcttagc taagtatttg gagtcatact      840

ttctttctag ggaaaatcat attcctactc tttcagctgg tgtagatata actaatccta      900

atatgactcg cttacttaaa aaggttcgtc ttctaaatga atatcagaaa gaagctccat      960

ctttctggat tcgtcatcca gagaagtata tggaagaaat tgtggagagt actttgtcct     1020

tgttaacagt taaacataat caaagccatg ttgtctcaca aaagattttg gatccgatct     1080

acttttttgc attagttgat accaaggctg tgtggttcaa aaagtggatg catgcacatt     1140

atagcagaac tacagtatta agacttcttg aaacgaaata taagtctctg gtaactacag     1200

ccattcaaca gtgtgttcag tactttgaaa tgtgtaagac taggaaagct gatgaaactt     1260

tgggacattc aaagcattgc agaaacaagc agaaaacttt ctactactta ggacaagaat     1320

tacaatatat ttatttcatt cactcactgt gccttttagg aagattattg atctataaac     1380

aaggcagaaa actatttcct attaagctga agaataaaaa aggtttggta tccctcatag     1440

atctgcttgt tctttttacc caacttatct attactcacc aagttgtcca aagatgacat     1500

cagctgccca ttcagagaat tactctcctg caagtatggt gactgaagtt ctgtggatac     1560

tcagtgatca aaaagaatgt gcagtggaat gcttatataa caacattgta atagagacac     1620

ttcttcagcc tattcacaat ttaatgaaag gaaatgaggc atctccaaat tgctctgaga     1680

cagctttaat tcatatagct ggtattttgg caagaattgc atctgtagaa gaagggctta     1740

ttttactcct ttatggagca aatatgaact cttctgaaga aagtcctaca ggtgctcata     1800

taattgccca gttttcgaaa aaacttctcg atgaagatat ttctatattt tctggatcag     1860

aaatgttgcc tgtggttaaa ggagctttta tttctgtgtg tcgtcacata tatagtacat     1920

gtgaaggttt gcaggtgtta atcacttata atttgcatga atctatagca aaggcatgga     1980

aaaagacaag tttgctatca gaaagaattc ctactccagt agagggttct gattctgttt     2040

cttcagtaag ccaggaatcc caaaacatta tggcttggga agataatttg ttagatgatt     2100

tactacattt tgctgccacc cccaaaggat tactacttct tcaaagaaca ggtgctatca     2160

atgaatgtgt gacatttata ttcaatcgat atgcaaaaaa attacaggtc agcaggcata     2220

aaaaatttgg ctatggagtt ttggttacac gagtggcatc aacagcagca ggtggcattg     2280

cactaaaaaa gtcagggttt attaatgaac ttataactga attatggtcc aatctggaat     2340

atggaagaga tgatgttagg gtaacccatc ccagaactac tccagtggat cctattgacc     2400

gaagctgtca aaagtctttt ttagcactgg tgaacttgtt atcctatcct gctatttatg     2460

agcttgtaag gaatcaagat cttcctaata aaacagaata ttctcttcgt gaagtcccaa     2520

catgtgttat tgatattatt gatagactta taattttgaa ttctgaagct aagattcgtt     2580

ctttattcaa ctatgaacaa tcacatatct ttggtctaag ggactttata attgatggct     2640

tatcagtgga gagaaatcat gttcttgtta gaataaatct tgttggtggg ccattggaac     2700

ggattttgcc tccgaggtta ctcgaaaaga gtgataatcc atatccttgg ccaatgtttt     2760

catcatatcc attgccaaac tgctatctgt cagacattac aagaaatgct ggtataaaac     2820

aagacaatga tcttgacaag cttttattat gcctcaaaat atctgataaa caaactgaat     2880

ggatagaaaa ctgccaaaga caattttgca aaatgatgaa agccaaacct gatataatca     2940

gtggagaggc cttaatagaa ttacttgaaa aatttgtgct tcatctcact gaaagcccat     3000

ctgaatgcta cttcccttca gtggagtata cagctactga tgcaaatgtg aagaatgaaa     3060

gtctttcatc tgtgcagcag cttggcatta aaatgactgt caggtatggc aaattcctca     3120

gtctcttaaa agatggtgca gaaaatgatc ttacctgggt tttaaagcat tgtgagagat     3180

tcctgaaaca gcagcaaact tccataaaat cttctcttct ctgcctgcaa gggaattatg     3240

ctggccatga ctggtttgta tcttctctgt tcatgataat gttgggagac aaagaaaaaa     3300

cattccaatt tcttcatcaa ttctccaggc ttctgacttc tgcttttctt tggttgccaa     3360

ggctacatat ttctagttac cttcctaatg acactgtaga atctggcatc catccagtat     3420

atttttgcag cacccattat attgaaatgc tactgaaggc tgagttgcct cttgtgtttt     3480

cagcttttca catgtctggt tttgcaccat cacagatttg cctgcaatgg ataacccagt     3540

gtttttggaa ttacttagat tggatagaaa tctgccatta tattgctact tgtgttttcc     3600

ttggtcctga ttatcaagtg tatatctgta tagctgtatt caaacattta cagcaagaca     3660

ttctacagca cactcagact caagatctgc aagttttcct aaaagaagaa gcactgcatg     3720

ggtttcgagt gagtgattat tttgaataca tggaaatttt ggaacaaaac taccgaacag     3780

tgctgctgag agacatgcgg aacattagac tgcagagcac atag                      3824


<210> 2500
<211> 1073
<212> DNA
<213> Homo sapiens

<400> 2500
aagatggcga ctccctatgt tactgacgag accggcggca agtatatcgc gtcaacacag       60

cgacctgacg ggacctggcg caagcagcgg agggtgaaag aaggatatgt gccccaggag      120

gaggtcccag tatatgaaaa caagtatgtg aagtttttca agagtaaacc agagttgccc      180

ccagggctaa gccctgaggc cactgctcct gtcaccccat ccaggcctga aggtggtgaa      240

ccaggcctct ccaagacagc caaacgtaac ctgaagcgaa aggagaagag gcggcagcag      300

caagagaaag gagaggcaga ggccttgagc aggactcttg ataaggtgtc cctggaagag      360

acagcccaac tccccagtgc tccacagggc tctcgggcag cccccacagc tgcatctgac      420

cagcctgact cagctgccac cactgagaaa gccaagaaga taaagaacct aaagaagaaa      480

ctccggcagg tggaagagct gcagcagcgg atccaggctg gggaagtcag ccagcctagc      540

aaagagcagc tagaaaagct agcaaggagg agggcgctag aagaggagtt agaggacttg      600

gagttaggcc tctgaggcct ttggggaata gggaatggac tgcagaacaa accgtggggc      660

tctctggggt ctgggggaat acgggcaaca gcagtcagga ggggtacccc ccatactggc      720

ttacttccac ctcctgcggc ccagctctgt cctccagagc ctagcgtctc cctcaatcct      780

tcccttttct tcccaacttc tactttttgg actttccccc tcccattccc agtgttcaaa      840

atctcagtga ctaccccagg tacctttgct gctgatttgg gtgtcttgtt taaaagaaaa      900

tcaggtgggt gggaatctct tggagaactg aggctgaggg tagagggagt atgcccaagt      960

cttggagtct tggttcctgt tcgcggtgtt tatgggttat ttccctctcc atccctcatt     1020

tttttttttt ttttaaaaaa agcaaaaatg agaataaaca caagtagaca tgt            1073


<210> 2501
<211> 1119
<212> DNA
<213> Homo sapiens

<400> 2501
cagtcgcccc ggcaacagcc gcctccctcg cgtcccccac tccccctctg tctctccaag       60

gaaaactagg cccctgcgcg gccaacgccc aggatccgca agctgcgcgc ccacgagttt      120

cagcacccat ttggactttc acaatcagag atggcagcgg taaaggcatc aacatcgaaa      180

gctaccaggc cttggtattc tcatccggta tatgcaagat actggcaaca ttatcatcaa      240

gcaatggctt ggatgcaaag ccatcacaat gcctacagga aggccgtgga atcctgtttc      300

aatcttccat ggtacttacc ttctgcgctt cttccccaaa gctcttacga taatgaggct      360

gcgtatcctc agtccttcta tgaccatcat gtggcctggc aggactaccc ctgcagttct      420

tcacatttca gaagatctgg gcagcatcca cgttacagca gtaggatcca ggcatccaca      480

aaagaagacc aagctttgtc caaagaggaa gagatggaga ctgagtcaga tgcagaggta      540

gaatgtgacc tgagcaatat ggaaatcact gaagagctcc gccagtactt tgcagagacc      600

gagaggcata gagaagaacg acggcggcag cagcagctgg atgcagagcg cctggacagc      660

tatgtgaacg ctgaccacga cctgtactgc aacacccgcc ggtcggtaga agccccaact      720

gagaggcctg gtgagcggcg ccaggccgag atgaagcgtt tgtacgggga cagtgctgcc      780

aagatccaag ccatggaggc cgcggtgcag ctgagctttg acaagcactg tgaccgaaag      840

cagcccaagt actggccggt catccccctg aagttctgag ctcagggcac agggtaccca      900

gcctctcctt cttccttttg ggtacacgct ctttatctct ccttctgtac atttcttagg      960

gaaaggggac tttgtactgg ggtacaggca tgttcaccac agtcccagtg ggcctgtcac     1020

ggggtggatg tactatgcca gccacttgga ggtctgcagg acatgttctg ttgccaacat     1080

gataaatttt ctcctgacat aaaataattt tgcatatac                            1119


<210> 2502
<211> 2160
<212> DNA
<213> Homo sapiens

<400> 2502
ggccgggttg ccagattacg ggaaagccat ttaagaagtt cctggaataa tattagtcag       60

agtaatatag gatctgcagg aagtgtctca agatagttgg aaaagaagaa tttctagact      120

cttcatcaag atcttcattt atacagctgt taaatccaag gctactttgg tgaaagcatg      180

aataaaaata catctactgt agtatcaccc agtctacttg aaaagatggt cgtttgaagc      240

caggagatca acttgtctca gtcaacaagg aatctatgat tggtgtatca tttgaagaag      300

caaaaagcat aattaccgga gccaagttga gtactaggtt agaatctgct tgggagatag      360

cattcataag acaaaaatcc gacaacattc agccagaaaa tctgtcatgt acatcactta      420

tagaagcttc aggagaatat ggacctcaag cctcaacatt aagtcttttt tcttctcctc      480

ctgaaatact aatcccaaag acctcatcca ctcccaaaac aaataatgac attttatctt      540

cttgtgagat aaaaactgga tacaacaaaa cagtacagat tccaattact tcagaaaaca      600

gtactgtggg tttgtctaat acagatgttg cttctgcctg gactgaaaat tatgggctac      660

aagaaaagat ctccctaaat ccctctgttc gctttaaggc agagaaactg gaaatggctc      720

taaattatct tggtattcag cccacaaagg aacaacacca agccctgaga cagcaagtac      780

aagcagactc aaaagggaca gtgtcttttg gagattttgt ccaggttgcc agaaacttgt      840

tttgcttgca gttggatgaa gtaaatgttg gtgcacatga aatttccaat atattagatt      900

cacagcttct tccttgtgat tcttcagaag cagatgaaat ggaaaggctc aagtgtgaaa      960

gagatgatgc cttgaaagaa gtaaatacac ttaagtggcc agggcagaat tagatgaaga     1020

gccaataaag caagtcgtgg caattttgga tcctgtgagt tctttgggaa atacattttt     1080

tttcatgtgc agggctattc ttaagggaca tcatgttttg ctaacgtaat ttggaattaa     1140

tattatttta gagaggaaaa aaacacacat atcccaaata tactgtaaca tttttcttct     1200

ctttttttgt ttgtttggtt ttttgattct tgtttttgtt ttgtgttttt gagacagggt     1260

cgcactctgt cgcccaggct ggagtgcaat actgcaatca cgtctcactg cagcctcaac     1320

ctcctgggtt caagtgattc tcccacctca acctcccaag taactgggac aacatgtcca     1380

tgccaccatg ctcaactaat ttttttttaa atttttattt tgtagagatg gtgtctcact     1440

attttgttca gactggtctc aaacacctgg gctcaaatga cccacctacc tcagcctctc     1500

aaagtgctgg gattacaggt gtgagccacc atgtctggcc ttgattctct ttatgtggtt     1560

tcattctgtt tttagaagaa tattacattt aaattatatc ctaattttta tagaaagcta     1620

tattttccaa atctttagga aaagcaacat aactacttga tttaccacta attcgtcata     1680

ggcacatatt tttaaaatta ttttattaaa taaggtatag tatattgata attatttaat     1740

ttttattaaa tagaaaatat ttacaccaaa aggaaagaaa atttgttttg ctaccttagt     1800

ttttataatc tcaacctcta gaggaagcca ttgttgcaaa tatattattt atcttttcat     1860

agatttttct ctacacagaa aattatattt tttaaaaata ggcagggcat gatggctgac     1920

acctttaatc gcagtacttt gggaggctga ggcaagagga ttacttgagc tcaggagttt     1980

aacatcagcc tgggcaacat agcaggaccc catctctact atttaaaaca taaaaacaaa     2040

aataaataaa tatatgtata tgtggggaca gggagtatgt gagaaatttc tgtactttcc     2100

cttcaatttt gctatgaatc caaaactgct tcaaaaaata ataaagcctt aaaaaatttt     2160


<210> 2503
<211> 1234
<212> DNA
<213> Homo sapiens

<400> 2503
attgtgggtt gctgggcggc ccggtctcgg agaagagggg agagtggcgg gccgctgaat       60

aagcttccaa aatgatggat tctcagctgg tagctggtgt tgcattcaag aagactttct      120

cttacgctgg gtttgaaatg caacccaaaa agtaccacaa tcccaagatt gcccttttga      180

atgtcgagct cgagttgaaa gctgagaaag acaatgctga gataagagtc cacacagttg      240

aggattatca ggcaattgtt gatgctgagt ggaacattct ctatgacaag ttagagaaga      300

tccatcattc tggagccaaa gttgtcttgt ccaaactccc cattggggat gtggccaccc      360

agtactttgc tgacagggac atgttctgtg ctggccgagt acctgaggag gatctgaaga      420

ggacaatgat ggcctgtgga ggctcaatcc agaccagtgt gaatgctctg tcagcagatg      480

tgctgggtcg atgccaggtg tttgaagaga cccagattgg aggcgagagg tacaattttt      540

ttactggctg ccccaaggcc aagacatgca ccttcattct ccgtggcggc gccgagcagt      600

ttatggagga gacagagcgg tccctgcatg atgccatcat gatcgtcagg agggccatca      660

agaatgattc agtggtggct ggtggcgggg ccattgagat ggaactctcc aagtacctgc      720

gggattactc aaggactatt ccaggaaaac agcagctgtt gattggggca tatgccaagg      780

ccttggagat tatcccacgc cagctgtgtg acaatgctgg ctttgatgcc acaaacattc      840

tcaacaagct gcgggctcgg catgcccagg ggggtacatg gtatggagta gacatcaaca      900

acgaggacat tgctgacaac tttgaagctt tcgtgtggga gccagctatg gtgcggatca      960

atgcgctgac agcagcctct gaggctgcgt gcctgatcgt gtctgtagat gaaaccatca     1020

agaacccccg ctcgactgtg gatgctccca cagcagcagg ccggggccgt ggtcgtggcc     1080

gcccccactg agaggcaccc cacccatcac atggctggct ggctgctggg tgcacttacc     1140

ctccttggct tggttacttc attttacaag gaaggggtag taattggccc actctcttct     1200

tactggaggc tatttaaata aaatgtaaga cttc                                 1234


<210> 2504
<211> 2914
<212> DNA
<213> Homo sapiens

<400> 2504
agcctgcgct tcggaagcat ggatgtgcgc ctgcgctgcg ctagggcgcg gcgggcggtt       60

tgaattttgc ttacagagtc ccgtctcacc atcctgggct tccaacggag actgcggtat      120

ccgcagctgg agacccagcg gcgagtagcc ttttgctccc ggacggactt gaggttggag      180

tctgtgtgtt ggggaccctg cctttggaag cgcccgagag gcttaaagga tggcctcgtc      240

agatctggaa caattatgct ctcatgttaa tgaaaagatt ggcaatatta agaaaacctt      300

atcattaaga aactgtggcc aggaacctac cttgaaaact gtattaaata aaataggaga      360

tgagatcatt gtaataaatg aacttctaaa taaattggaa ttggaaattc agtatcaaga      420

acaaaccaac aattcactca aggaactctg tgaatctctt gaagaagatt acaaagacat      480

agaacatctt aaagaaaacg ttccttccca tttgcctcaa gtaacagtaa cccagagctg      540

tgttaaggga tcagatcttg atcctgaaga accaatcaaa gttgaagaac ctgaacccgt      600

aaagaagcct cccaaagagc aaagaagtat taaggaaatg ccatttataa cttgtgatga      660

gttcaatggt gttccttcgt acatgaaatc ccgcttaacc tataatcaaa ttaatgatgt      720

tattaaagaa atcaacaagg cagtaattag taaatataaa atcctacatc agccaaaaaa      780

gtctatgaat tctgtgacca gaaatctcta tcacagattt attgatgaag aaacgaagga      840

taccaaaggt cgttatttta tagtggaagc tgacataaag gagttcacaa ctttgaaagc      900

tgacaagaag tttcacgtgt tactgaatat tttacgacac tgccggaggc tatcagaggt      960

ccgaggggga ggacttactc gttatgttat aacctgagtc ccttgtgaac ttttgaacat     1020

accaacaggg tatagagtat agaggctatt tctataattt tcttatatat aattttttta     1080

acttttaatc ttttttgttt cctttttttt ttttttgaga caggatcttg ctttgtcacc     1140

caggggcttg ctttgtcacg caggctagag tgcagtggcg caaacatggc tcactgcagc     1200

ctcaacctcc caggctcaag tgatcctccc acctcagccc cctgaatggc tgggactaca     1260

agcgtgcgcc accatgcctg gctaattttt gtattttttg gagagatggg gtttcaccat     1320

gttgcctagg ctggtcttga gctcctgagc tcaaacaatc caccctcctc agcctcccaa     1380

agtgctggga ttacaggctt gagccaccac acctgaccta ttcttgtttc ttataaaaat     1440

aaaacttttt tggataaagc ttatttcttg tttttttctt tttctttttt tttttttttg     1500

agacagtctc gctctttcac ccaggccgga ctgcagcggc gctatctcgg ctcactgcaa     1560

actctgcctc ccaggttcac gccatcctcc tgcctcagcc tcctgagtag ctgggactac     1620

aggcacctgc caccacgccc agctaatttt ttgtattttt agtagagatg gggtttcacc     1680

gtgttagcca ggatggtctc gatctcctga cctcatgatc cgcccacctc ggcctcccaa     1740

agtgctggga ttacaggcgt gagccaccgc gcccggccaa cttatatatt ttcaagattc     1800

acctcctctc accaaatatt taactacctg ctgaatacgc ctctgtacta ggcacataat     1860

ggaactaaaa aatgctcatg tccagttttt gtgttgagtg aacaatgctg cagaccctaa     1920

taagattggg tacagatcgg catgcgcctg tagtcccagc tactcaggag aattgcttga     1980

acctaggagg tggaggttgc agtgagccga gatcgtgcca ctgcactcca gtctgggcaa     2040

cagagcgaga ctccatctca gaaaaaaaga aaaaaagact gggtacagat gtgatattgg     2100

aagaaaaaga tcaagctgat gaggttagga tacccaggcc ctttggactt aaagatcact     2160

agtgtctaaa ttccatcgat ggcatttcag tctataggta aacttcctgg aagctggatt     2220

tggagacagt ttatcatctg attattgggc tttcgtatag gtccttaggg agcagcttac     2280

ctgaaatgca tttagtgtac accagtctgt aaacttcaac ctgtaatgaa agtgtaataa     2340

atgtacattg agttgatgtg ataatgtgat ataataagaa atatatattt gatcttccta     2400

tctagttcct tgttcagagc tcctaaaacc cttgtaattt ccaaagtgat ggagtacatc     2460

ttttgttcta gtatttggtc tttgacccca gttcctgaca caaagctcct aaattccttt     2520

aaatttccca gtgataggag aattttttgt tctaatgagg tcactcttga tgggcacctg     2580

gataactcag gatgggggct gctcacaaag accacatcat gattggaagt ttcaaacttt     2640

cagtctccca cctccagaga ggggagaggg gctggagatt tgtgtcaata atccatcagg     2700

cctatgtcaa caagacataa tccgttaact atggagttca gggagcttca gggttggcaa     2760

acattttgat gtgccaggaa ggtgacgcac tccagcttta tgaagtcagc aagtcctgtg     2820

ctcaggatgc ttctggacct tgccccaggt accccttcat gtggctgttg ttcatctgta     2880

tcctttgtag tagccttaaa ataaactgtt aaac                                 2914


<210> 2505
<211> 1241
<212> DNA
<213> Homo sapiens

<400> 2505
atttctgctg ttttcttcta gttgtttcac agtttatttt tctcagaaga atcttcagaa       60

aacaagaaac atcatcccat ttgaggactg ctgtgagaca cacagttttc aggatgacac      120

acagaatgct gagttccaag tgatctgtca cctgacaatc gactggatga gtaagattac      180

aagtctttga aattaaatga cacactaaat taactgaaga caagaggagg aggaaagact      240

ggattggcta aactctaaca cagagaaaga ataaaagtgc attccacctt ttatacagat      300

attttcccac aattagctaa cttgataatt gcctatctat taagataaac aataacaagg      360

aaatagcttt tatgtggtga caacagctcc tcagctgagt ataaaagtgg acatgggata      420

aggagattcc cacattcgaa aaactcactg tcttggaaac ctacctagaa cctccaccct      480

ctgacaccat ggttaactct tgttgtggct ctgtctgctc tgaccagggc tgtgatcaag      540

gcctctgcca agagacctgc tgccgcccca gctgctgcca gaccacctgt tgctgcccca      600

gctgtgttgt atccagctgc tgccgcccat cctgctctca gactacctgc tgccagacca      660

cttgctgtcg ccccagctgc tgccacccag tctgttgtca gaccacctgc cgccccagct      720

gtggtgtgtc cagctgctgc cgcccactct gctgtcagac cacctgccac cccagctgtg      780

gtatgtccag ctgctgccgt ccactctgtt gtcagaccac ctgccgcccc agctgtggtg      840

tgtccagctg ctgccgtcca ctctgctgtc agaccacctg ctgccgtgca acttgctgcc      900

gccccagctg ctgtggatcc tcttgttgaa cctcatattg gactatcaac catgagccag      960

tcaccatccc atgatatgaa agtgtcattt atatcaactt gtccatgtgt taaatggcca     1020

tcagctttat tatcctgtta ttccactaag taactggtga aagggcatcc atctacattt     1080

aataccactc atttttccca tggatctctt cccagcagca ttcagacctc agatgcatga     1140

tgcagttaga ctaagcctct aagtttctga ctgttatgct tgatttgacc ttcaaaatta     1200

catattaact gttcttcaat aaatattatc ttaatatcag t                         1241


<210> 2506
<211> 1683
<212> DNA
<213> Homo sapiens

<400> 2506
ctgaaggtct ggtgatagct gggtgcagga atattgtgca ggagggctat gtgtcctgga       60

ccatgaagaa ggatgacttc tgactgctcc tccacacact gctctcctga gtcctgtggc      120

acggcttccg gttgtgcacc tgcctcaagc tgctccgtgg aaacagcttg tctccccggt      180

acctgtgcta catcccgatg tcagactcca agcttcctat ccaggtctcg cgggctgact      240

ggttgcctcc tgccatgcta ctttactggg agttgtaata gtccctgctt ggtggggaac      300

tgtgcctggt gtgaggatgg ggtgttcact agcaatgaga aggagacgat gcagttcctg      360

aatgacagac tcgccagcta tctggagaag gtgcgcagcc tggaggagac caacgcagag      420

ctggaatcca ggatccaaga acaatgtgaa caggatatcc caatggtgtg cccggattat      480

cagcgttact tcaacaccat tgaagatctc caacaaaaga tcttatgcac gaaagcagag      540

aattctagac ttgctgtaca gcttgacaac tgcaaactgg ccactgatga ctttaagtca      600

aagtacgaga gtgaactgtc ccttcgccag ctgttagagg ctgacatcag cagcctgcat      660

gggatcctgg aggaactgac cctgtgcaaa tctgatctgg aggcccatgt ggagtctctg      720

aaggaagatc tcctttgcct taagaaaaac catgaagagg aagtcaactt gcttcgtgaa      780

cagcttggcg accgcctcag tgtggagctg gacactgccc ccacccttga cctcaacagg      840

gtcctggatg agatgcgctg tcagtgtgaa acggtgcttg ccaacaatcg cagagaagct      900

gaagaatggt tggctgttca gacagaagag ctgaatcagc agcaactgtc cagcgcggag      960

cagctgcagg gctgccagat ggagatcttg gaactgaaac gcacagccag tgctctggaa     1020

attgagctcc aagcacagca aagcctgaca gaatctctgg aatgcaccgt ggcagaaacc     1080

gaggcccagt acagctccca gctggcccaa attcagtgtc tgatcgataa cctggagaac     1140

cagctggccg agatccgctg cgacctggag cgacagaacc aggagtacca ggtgctcctg     1200

gacgtgaagg cccggctgga gggtgagatc aacacgtact ggggcctgct ggacagcgag     1260

gacagcaggc tttcctgtag cccatgttcg accacatgca cctcgagcaa cacttgtgag     1320

ccatgctcag cctatgtcat ctgcactgtt gaaaactgct gcttgtgaat gttaaggaca     1380

gcaggtagag gaatcaaagc cagcagcatc ctagaaagga gatggggctt caaccaggga     1440

catccaaacc ggaagcacaa atccaggagg ctctcatatc ctggaattgc cctccaggta     1500

tcctcagtct ttctgcttta ctatttcctc tccttccggc ttatttgtgg tatactggaa     1560

gcccataaag cattcttgct catctccaaa taaaacgtgt tttattcctt tagcgtggta     1620

aatatagctc tatggctgat tactgttgat agaatattca ttttatggca aggaaatcat     1680

cta                                                                   1683


<210> 2507
<211> 1021
<212> DNA
<213> Homo sapiens

<400> 2507
tgctcctcta cctgctctac tctcaatccg ccagaatcat gggctgctgt ggctgttctg       60

gaggctgtgg ctctggctgt gggggctgtg gctccggcag tgggggctgt ggctctggct      120

gtgggggctg tggctccagc tgctgtgtgc ccatttgctg ctgcaagcct gtgtgctgct      180

gtgtgccagc ctgttcctgc tccagctgtg gctcctgtgg gggctccaaa gggggctgtg      240

gctcttgtgg gagctccaag ggtgggtgtg gttcttgtgg ctgctcccag tccaactgct      300

gtaagccctg ctgctcctcc tcaggctgtg ggtcattctg ctgccagtcc agctgctcca      360

aaccctgctg ctgccaatcc agctgctgcc agtccagctg ctgcaagccc tgctgctgcc      420

aatccagctg ctgccagtct agctgcttca agccctgctg ctgccagtcc agctgctgtg      480

tccccgtgtg ctgccagtgt aagatctgag gctctggacc cagaccttca ggtttctcct      540

ctttggtgaa agcatttctt atggtttctc tgaatcagtt catcccacac atcatcctga      600

ggcacctgca cctgctctag ctcatcatcc atgcatgcac ctctttccat ggctcggctc      660

tcctctaggc cctgccttca gcttcctcac tccggaaaca tgtgtttcct tgatgcagga      720

ggtgttcttc cctggacgcc atggtgttcc ctgcacttgg gtgtggacca tcttcttctt      780

ctccctgggc tgactgagat gctaggtctg accccacaag gccaggccga cattcctgag      840

tgatcactaa gaaccagttt ctcaaccacc actgggattc tgggtcctcc tgggctgctg      900

cctgttctcc tgtgacccac ctgtgagcaa gaaggtctcc ttccttcctg ttgtctccat      960

ctatttaaaa aaaaaatgaa tgaatttcct tgcaataaag cctctcatgt ctgtaaacca     1020

a                                                                     1021


<210> 2508
<211> 1058
<212> DNA
<213> Homo sapiens

<400> 2508
gatccaccct caatctacca gaatcatggg ctgctgtggc tgctccggag gctgtggctc       60

cggctgtggg ggttgtggct ccggctgtgg gggctgtggc tccggctgtg ggggctatgg      120

ctctggctgt gggggctgtg gctccagctg ctgtgtgccc gtctgctgct gcaagcccgt      180

gtgctgctgt gtgccagcct gttcctgctc cagctgtggc tcctgtgggg gctccaaggg      240

ggactgtggc tcttgtgggg gctccaaagg gggctgtggt tcctgtgggg gctccaaggg      300

gggctgtggc tcctgtgggg gctccaaggg gggctgtggt tcttgtgggg gctccaaggg      360

gggctgtggc tcctgtgggg gctccaaagg tggctgtggt tcctgtgggg gctccaaggg      420

gggctgtggt tcttgtggct gctcccagtg caattgctgt aagccctgct gctgctcctc      480

aggctgtgga tcctgctgcc agtccagctg ctgcaatccc tgctgctgcc agtccagctg      540

ctgtgtcccc gtgtgctgcc agtctagctg ctgcaagccc tgctgctgtc agtccagctg      600

ctgtgtcccc gtgtgctgcc agtgtaagat ctgaggctct gaacccagac cttcaggttt      660

cacctgtttg gtgaaagcat ttgttatgat ttccctgaat taattcatcc cacgcatcct      720

ccctgaggca cctgcccctt ctccagctca tcatccatgc acgcacctcc ttccatggct      780

cagctctcca ctgggccctg ccttcagcct cctcactccg gaaatgcatg tttccttgat      840

gcaggaggtg gccttgcctg gacgcgggca cccagccaac tgccatggtg ttccctgcac      900

ttgggtgtgg accatcttct tcttctccct cggctgactg agatgcaagg tctgacccca      960

caaggccagg ccaatgttgc tcagtgatca ctaagaacca gcttctcaac caccattggg     1020

accctggatc ctccagggcc gctcgctgcc tgttctcc                             1058


<210> 2509
<211> 898
<212> DNA
<213> Homo sapiens

<400> 2509
cctctacctg ctccaccctc aatccaccag aaccatgggc tgctgtggct gttccgaagg       60

ctgtggctcc ggctgtgggg gctgtggctc cggctgtggg ggctgtggct ctggctgtgg      120

gggatgtggc tccagctgct gtgtgcccgt ctgctgctgc aagcccgtgt gctgctgtgt      180

gccagcctgt tcctgctcca gctgtggctc ctgtgggggc tccaagggag gctgtggctc      240

ctgtgggggc tccaaggggg gctgtggctc ttgtgggggt tctaaggggg gctgtggttc      300

ttgtggctgc tcccagtgca gctgctataa gccctgctgc tgctcctcag gctgtgggtc      360

atcctgctgc cagtccagct gctgtaagcc ctgctgctgc cagtccagct gctgtaagcc      420

ctgctgctgt tcctcaggct gtgggtcatc ctgctgccag tccagttgct gcaatccctg      480

ctgctcccag tctagctgct gtgtccccgt gtgctgccag tgtaagatct gaggctctgg      540

actcaggtct catgtgagtc ctgctaaccc cattttccga agctgtgacc tgtccttcat      600

cgttgagccc caaaccactg ctcagggtcc attcctcact ataagatgaa gccatatctg      660

cctgcctttt cctaaggaga gtccacccta attaatgtcc attccctcct aacaaattct      720

cttcccaagt caactgcaac tgcggctgaa tcacccctca cccgctagcc ttgcctttgc      780

ttgtgtattc agaggcctga gctcctgaac ccacttgaag tcctgtcttt tccagctgga      840

gcagctgggc atgagtgtcc cacctgcaac aaggtgggcg tttaagaggc ttccttgg        898


<210> 2510
<211> 5060
<212> DNA
<213> Homo sapiens

<400> 2510
cgggagccca ggcgggcagg ccgctggggt cggggctgca cgtacgagag ccgggacgcc       60

cgggttcaga gcgaaggagg aggcatggct tcggtgttca tgtgtggcgt ggaggacctg      120

ctgttcagcg gcagccgctt cgtatggaac ttgaccgtgt ccacgctgcg gagatggtac      180

acggagaggc tgcgggcttg ccaccaggtg ctgcggacgt ggtgcgggct gcaggacgtg      240

taccagatga cagaaggcag gcactgccag gtgcacctcc tggatgatag gagactggag      300

ctgctggttc agcccaaact tctagcaaga gagttgctgg acctagtggc ttcacatttc      360

aacctgaaag aaaaggagta ttttggaata acattcatag atgacacagg tcagcagaac      420

tggctgcagt tagatcaccg agttcttgac cacgatttgc ccaagaaacc aggcccaacc      480

attttgcact ttgctgtgag gttttacatt gagagcatat cgtttttaaa ggataaaacc      540

accgtggagc tgtttttcct gaatgcaaag gcctgtgtgc acaaggggca aatcgaagta      600

gagagcgaaa ccatcttcaa gttagcagcg tttattttac aggaagccaa gggagattat      660

accagtgatg aaaatgccag gaaagattta aagacattac cagcctttcc aaccaaaact      720

cttcaggagc atccatccct tgcctactgt gaggacaggg taattgagca ttatttgaaa      780

atcaaaggtc tcactcgagg tcaagctgtg gttcagtata tgaaaatagt agaagctcta      840

ccgacttacg gtgtccatta ttatgcagta aaggataagc aaggacttcc ttggtggctt      900

ggaataagct ataagggaat tggccaatat gatatacaag acaaggtgaa gcctcggaag      960

ttattccaat ggaaacagct ggagaactta tatttccgtg agaaaaaatt tgctgttgaa     1020

gttcatgatc cacgaaggat ttcagtttca agaagaacct ttgggcaaag tggcttgttt     1080

gtgcaaacat ggtatgctaa ctcttctctc atcaagtcca tttgggtaat ggcaattagt     1140

cagcatcagt tttacttgga ccggaagcaa agcaaagcaa aaattccttc agccaggagt     1200

ttagatgaga ttgcaatgga tttgacagag acaggaacac aaagggcctc caagctggtg     1260

acactggaga cgaaaagtca gttcatcatg gcaagtaatg gcagtttaat ctcctcaggt     1320

tctcaagact cagaagttag tgaagagcaa aagagagaaa aaatccttga actaaagaag     1380

aaggagaaac tattacaaga aaaacttctg aaaaaagttg aggagcttaa gaagatctgt     1440

ctgcgggagg ctgagctcac aggcaaaatg ccaaaggagt atcccctgaa cataggcgag     1500

aagcctcctc aggtcagaag acgtgtgggt actgcgttca aattagatga caacttgctg     1560

ccgagtgaag aagatcctgc tttgcaagaa ctggagagta attttctaat acaacaaaag     1620

ctggtggaag ctgcaaagaa acttgccaat gagccagacc tttgtaaaac tgtgaagaaa     1680

aagcgaaagc aagattacac agatgcgatg aaaaagcttc aggagattga aaatgcaata     1740

aacgaatacc gaattaggtg tggaaagaaa cccagccaga aagcaacagt gttaccagaa     1800

gacataatcc cctcagagag tagctctttg tctgacacca ccacctatga tgatcccagt     1860

gatgccttca cttttcctgg gcagcgatca agttcagtac ctcattctcc aagaattctt     1920

ccccccaagt ctcttggtat tgagcgaatc catttcagaa agtcgtccat caatgaacag     1980

tttgtggata ccaggcagtc cagagaaatg ctgtccacac acagcagccc ttacaaaact     2040

ctggagaggc ggccccaggg aggacgaagc atgcccacca cgccagttct tacccgaaac     2100

gcctacagca gcagccactt ggaacccgaa tcttcatctc agcactgccg ccagcggagt     2160

ggaagcctgg agtcccagtc ccacctgctc tccgagatgg acagcgataa gccatttttc     2220

tccctctcca aatcccaaag aagcagcagc acagaaatcc tcgatgacgg gtcttcttat     2280

acaagccaat caagcacaga gtattactgt gtgacaccag ttaccggccc ctattacacc     2340

acccagaccc tggacactcg caccaggggt cggaggaggt caaagaaaca gaatgtttct     2400

acttcaaatt caggaagcat gcccaaccta gcacaaaagg atagtttgag gaatggtgtt     2460

tactcaaaga gtcaggagcc accgtcttcc agttactaca ttgccgggta cacaccctat     2520

gcagagtgtg acttttatta cagtggtggt tatgtctatg agaatgacac cgagggacag     2580

tatagtgtca acccttccta ccggtcctca gcccactatg gatatgagcg ccagagggac     2640

tacagcagat cctttcacga agatgaggtc gaccgggtac cccataaccc atatgcaact     2700

ctccggctgc caaggaaggc tgctgcaaaa tcggagcaca tcaccaaaaa catccacaag     2760

gccttagttg ccgagcactt gcgtggctgg taccagcggg cctctgggca gaaggatcag     2820

ggacacagcc cgcagaccag ctttgactca gacaggggat cacagagatg cctggggttt     2880

gcggggctgc aagtaccttg ttctccaagc agtcgtgcat cctcgtactc ttcagtgtct     2940

tctacaaatg cttctgggaa ctggaggacc cagttaacca tagggctgtc ggattacgag     3000

actccagcac attcttctta caccagctgc tatggcaatg tctataatcc tttaccctct     3060

ccaagcagac aatacacaga aatcagtcaa ctggatggta cagatggaaa ccagctggaa     3120

gacaacctgg agagtagtga gcagagactc ttttggcatg aagattcaaa gcctggaaca     3180

ttagtctgaa ctgcagttgg acctcctgac caagcactgc gttctcacac tagtgtgcct     3240

tgcaaattgt atttgtcttc cgagaggatg ttcgttttag aaacctaaag acatcaaagg     3300

ttgaagagaa gacttagttg ccctggaagt gaatcagtga atcacacacc aagccccaca     3360

aagcccctaa aggaggattt ggcctttcaa actctaggca ctaacgtaac tgtagggtct     3420

gcccacatgt tgaagtattg ccaagagagg actcagtgtg aagccttcat caatagcaag     3480

cactttttaa gggagtaaaa gttgttaaag gcaaacctca aaaacatgaa agggcattca     3540

ggatgtccca tggcaataag aacaggggaa atctcagagc acaattcagc aggatgagag     3600

aaggggaacc agaagctccg gagtcattgc tcacttcaga gtttgaattc gtgagctgac     3660

aaagagtaac atgctctttc tacacagaca tggacaattt agacagtatt ggaaaattac     3720

ttgaagctgg attttcatga agttctgaat gagtgtaaat gttttttagg atactataaa     3780

gagtgatgtt tttcataagc accataaaat gggttctgga aaaactgatt accttagcat     3840

cctgtaatat aacttatggt agcagattgg ggaaaatgaa gcagcccact gaataattga     3900

caaagtctgc ttggagaaca ttctaaggta caatatcatg gagctccttt ttcctttctc     3960

cactaattgc gtgatgagct attgttctgg ctgttaattc tccaactcgg ctgtcatttg     4020

aagtggcaga cttaatatgg aaagttttta taattatgag tttgaaaaag cattttaaga     4080

tgatacagaa agtatccaaa acaacagaaa aaaaaagcca cgtcatttta gatgaattgc     4140

gtgccttaaa atggtgaacg ttagaaaatt aaacaagtct ggattccaca agtagttcca     4200

agtcaccaag tgacaaaaac aaggttaaca ttaaaaaaga aaaacaacaa caacgacaaa     4260

aagctccaag ctgcagtgga tttaattatg aggctaaaac tacctcatac tttccttgga     4320

agaactaatt agctatggtt tattgtaggg ttttgtttgt ttgtttttta aagcaaatga     4380

tttccatatt ccagattgat cttttttgtc atctttgctt caaaattaca taaaaggtgc     4440

tcctttcccc cttcttttat acaagtttct tgttcatatt gtgaatagaa aagtttctga     4500

acaacttttt tggaacattt tctatctata ttccaaagca tgtaatatat acataaaaac     4560

gatttgttaa actggtcctt agtcatttgt ataattagaa atgaagtttg ggaaaaaatt     4620

ttggaaaaaa gacaagcaaa aaaaaataac ttattccttt tttgcatatt tgtatagcct     4680

tctagaatca gaaataacct ttttgcatat tcttttattg ttctgacttt tcaagaccta     4740

ttattttttt acataggtca ataaacaaaa ggtgtgctac tgaaaatgtt tacgttttct     4800

tccatttatg tcaggggttc atgtgaagca ggtcgcagtg ctctacttca agtaatcata     4860

ttgggcaagg cttcggattt ttatttatag tattaccgta ttttattaat tccgggatgt     4920

acatttttaa atatttacat taaaaacatg gttcatcttt ttattgatgg catattctac     4980

ttgaattggc agttttttct taatagtaca ttaaaaataa tgctgtgtct tacaataaag     5040

ttgccttaga attgatgaaa                                                 5060


<210> 2511
<211> 1604
<212> DNA
<213> Homo sapiens

<400> 2511
cggcgcgatg accacgctac gggcctttac ctgcgacgac ctgttccgct tcaacaacat       60

gtgagtgaca cgcgcctagg gccagccgct cttggccggg cctcgcttcc cggccccgcc      120

agctccggcc ccagccgcgc cttcccggcc ggaccccaag cccggacggg gacccgcgag      180

aaccaccccc cgccggccaa cgtgggcgcc tccctggggc cacagggtcc agggagaggt      240

gggcctggag tcgacgcacg ccggccttgg cgaccttggc cgaggtgctc aaactttgtc      300

tctggaccct gcgagctggc aggttctggg gcagcgctcg ggcctccgct cgtggtcgct      360

gtcaggaggc gctggggtga tggggcgagc tggagacgcg gcctggagcc cacgacctgg      420

gcttctcgcc ctgccctact gcttgctggt tcgtggccgg gccgcgcctc ttctgggcag      480

agggcaccgc cgacggccag gccgcagagg gggcttgcga ggatcggaag ctggtcagca      540

gctgttggga tgtgtacatc gtgaagccca cctggtggcc gtggttaaat tgtatccaaa      600

tgaaatgaca ctgatcactg cgtcccctgc agcagatgct gtctcagtca tgtaacttgg      660

atccacttac agaaacttat gggattcctt tctacctaca atacctcgcc cactggccag      720

agtatttcat tgttgcagag gcacctggtg gagaattaat gggttatatt atgggtaaag      780

cagaaggctc agtagctagg gaagaatggc acgggcacgt cacagctctg tctgttgccc      840

cagaatttcg acgccttggt ttggctgcta aacttatgga gttactagag gagatttcag      900

aaagaaaggg tggatttttt gtggatctct ttgtaagagt atctaaccaa gttgcagtta      960

acatgtacaa gcagttgggc tacagtgtat ataggacggt catagagtac tattcggcca     1020

gcaacgggga gcctgatgag gacgcttatg atatgaggaa agcactttcc agggatactg     1080

agaagaaatc catcatacca ttacctcatc ctgtgaggcc tgaagacatt gaataaccct     1140

gggcagtggt tcttaggcag atactctaga tgctttatgg acaatattat tttcattgga     1200

tgattctgga gctctattag gagaaaagta atcattttag gtcttaaaga cttcaagaaa     1260

atacaggtta tcaatttatt ttaaatctca ttgtttccag ttagcaatat catacctatt     1320

aaagctgttc attgtaacaa aattcaatca aaaaggcagc taggtcagaa ggaaacatac     1380

cactctcatg gttcatagta ttcactgtat gtatgctagg gaaaagactt gctccagtct     1440

cctcctcagt tctgtgcctg agaaccactg ctgcatatat ttgtttttaa attttgtatt     1500

gaactgttaa ttgaagcttt aaaagcatat atgaaatgta taaatctaag atgtataata     1560

cattattgac tctatgaatg ttttctgaag tttgttagtc attt                      1604


<210> 2512
<211> 412
<212> DNA
<213> Homo sapiens

<400> 2512
agtatgcacc gcgatgcgcg cctcaccctg catctcccag cccgcagcca gctggcatcc       60

tagaccctct gccctgcgac caacagccgg gagcggacca gacaccagaa ctcccggaac      120

ggttgaagac ggttccgctc cctgtcccgc ctttcgcagc ccagcagttt cgccctgcgg      180

agaggagcct tgctgtttcc aaatctctcc tgctgaagag acattggagc tagggcggct      240

agtttcacct ggtaattgtg acaccctgtc tcctcgagct gcaggctttt atgcttgtca      300

tgttcgaagt ttgatacctt gcagatcaac aaagggccgg tggcctctca ctgcctccgc      360

ggcagggttg tcaagacatg cgcagtgcgg cccgtcccta gggctgggtt aa              412


<210> 2513
<211> 2866
<212> DNA
<213> Homo sapiens

<400> 2513
tccattccaa ataaaatcta taacaaatta ggtatagaaa gaatatacct caaaataaag       60

agatatgttc tttataagct ataggacaat cccatggtta acattattgt caatggtgaa      120

attttggaat tgtttttaag atttattata agaaaaagat gcccactctc actacttctt      180

tcaacaccgt attggaaatc ctgctcagaa tctaagacaa gagaaaaaag agcatttaaa      240

taagaaacaa caagttcttc tattcatgga gattaacgct caggtttttg cagattagat      300

ttaacagcat gaaatctgta ccatccagga atcaaaggat ataggacttt agggcatcaa      360

ttattaagag gctataggaa agcagaaatg ctcctggatg tttccattgt ccacacacaa      420

aatttcaaca gaccagcccc aggaagtaaa ggcacattcc tgactactgt tagttgatga      480

gcttttcacc aaaagcagag atgtgagacc tggcaggttt caaagacccc tcaagtgctc      540

cataccttga aattcacttc cacaaagcta gaacaccatc tgttcctgag ggatcaggtt      600

atcgtctgtt tcttttaggc actggccagt caggctttag tggacacgaa gccacagatt      660

tttagtgtaa aatgcctaat ctatcataat ctttaggtag atatttggag gcctgcacac      720

ttaaatgggt tggtgaaatg tcataccaga cacatggctg ggaattgggt ttttctcctc      780

cgctcttagc agcacctttg taacccagtg attacccccc tcatggctcc acggccacat      840

ccgcaaaaag ggtactggtg aacgtgacat tttcacgaag ccacagccca tggtcactcc      900

ctgcaaagct ctgaacttgc gcattcccag gccaggccgt ggttgtcttt ccaaggcggc      960

tcagcttgtg ctttgcttgg agagagcgga gggcagcagc acagtgacag cgtctgggac     1020

ctcagaccag tttccacagc cacttatgaa agcagacggc tccatgggct ggaggaggtg     1080

ggacgctctg gaaagaactc gggtgcgagt gggaaagaaa atcgagctga gcagctggaa     1140

gtcgaagtcg cgtgagtgag gaccagacac tctcgattta ggcaaaggcg gggtgcactt     1200

cccaacaaca catcctcctc actggcgaga ccaggcctgc ccttcaagtt cctctcctga     1260

tttaatcccc ttggcgaggg tttggcatga aatcaatggc cagcaagctt ggtaaacgaa     1320

gccgcctaca ccgccctccc cctccctgca cggccgcgcc ccgcctccgc tcctgtctca     1380

atctgggatt gtcctcctgt agccccacca tccaccgtgg ggaacggtgg agagactaca     1440

actcccagta tgcaccgcga tgcgcgcctc accctgcatc tcccagcccg cagccagctg     1500

gcatcctaga ccctctgccc tgcgaccaac agccgggagc ggaccagaca ccagaactcc     1560

cggaacggtt gaagacggtt ccgctccctg tcccgccttt cgcagcccag cagtttcgcc     1620

ctgcggagag gagccttgct gtttccaaat ctctcctgct gaagagacat tggagctagg     1680

gcggctagtt tcacctggta attgtgacac cctgtctcct cgagctgcag gcttttatgc     1740

ttgtcatgtt cgaagtttga taccttgcag atcaacaaag ggccggtggc ctctcactgc     1800

ctccgcggca gggttgtcaa gtttttcagg ttaagtactg cacgactact cgcttctgaa     1860

actgatagac actgcctcag ctccgtgcag ggcagacgca caagagcaga atctccgtgg     1920

gacatctctc tggagcatca atattactgc agtatttgga agaaacaaat ttaaataagt     1980

tctaaggtga agaatggaac atttaagaca agtctggaaa gtcatctgcc tttaataact     2040

gtcgtttgtc cttaacgtca gactttctcc aagaccaaaa ctctaagaac ttatttccat     2100

tcttacaaat agtaaaaatg ataaatcata tcaagtcaat tgaaagtcct gcctgctgct     2160

ttcctaaatt gcaatatggc cttggtatgg ttttatttgt acttttgtgg gggattcgtg     2220

gatctttaga ttaaaaaaaa aaaaataggt ttttgaacaa tttttgcaag tttgcagctg     2280

ttagttattg atttattttt ccaacccatc taattcttct gtctctctcc tctcctcagg     2340

ctcaataatt ccatgggtct ctaaggctgt gtttattttc tttaaatttt gttgatttac     2400

ttttatactc catttgattt tttctatctc tcaccttttc tcagactcag tcatcccaca     2460

ggtctgtaag gctctgttca ttttctttaa acttcttttt tttttcctct cctcagattg     2520

gataaattat attgctatgt ctctgtttct gaactataga aaagctcaaa attattattt     2580

ttatttctca ttttttatat ggctattttt tctctgctga tgtttcacat ctattcattt     2640

atgagaatat tttcctttgc cctcatgagc gtgtttataa tagctgcctt caaattcttg     2700

tctgccgttt acatcttgga catcttggag atggctactg cctgcttttt atcttgtgta     2760

tttattacat tttcacgtgt cttcacgcat cccttgaatt ggaaattgtg ccctggagac     2820

tgtatacaag actggattaa aaagactgga ttctgttttg tccctg                    2866


<210> 2514
<211> 666
<212> DNA
<213> Homo sapiens

<400> 2514
ttaatggacc tggacagtgg tgatgttaag agaagagtac atttatttga aacccagaga       60

aggacaaaag aagaagatcc aataattccc tttagtgatg gacccatcat ctcaaaatgg      120

ggtgcgattt ccagatcttc ccgtacaggt taccatacca cagatcctgt ccaggccact      180

gcttcccaag gaagtgcgac taagcccatc agtgtatcag gtggagttca tatggcaacg      240

aggccacatc atcagcacac tatgttgaaa gggacagatt cattgttact gatttatctg      300

gtcatagaaa gcattccagt actggggacc ttttgagcct tgaacttcag caggccaaga      360

gcaactcatt acttcttcag agagaggcca atgctttggc catgcaacag aagtggaatt      420

ccctggatga aggccgtcac cttaccttaa accttttaag caaggaaatt gaactaagaa      480

atggagaggt aaagaaactg aacctttcgg cttcatgctt aatgtatttg ttttctgctg      540

ctgcatcttg gttataccat tactgagtgc attttggtgt gcctatctct gatggatgat      600

tgattgcttt taaaacttat aacagaaata aaattgtaat cccagatttc ttaaataatt      660

ctttaa                                                                 666


<210> 2515
<211> 412
<212> DNA
<213> Homo sapiens

<400> 2515
agtatgcacc gcgatgcgcg cctcaccctg catctcccag cccgcagcca gctggcatcc       60

tagaccctct gccctgcgac caacagccgg gagcggacca gacaccagaa ctcccggaac      120

ggttgaagac ggttccgctc cctgtcccgc ctttcgcagc ccagcagttt cgccctgcgg      180

agaggagcct tgctgtttcc aaatctctcc tgctgaagag acattggagc tagggcggct      240

agtttcacct ggtaattgtg acaccctgtc tcctcgagct gcaggctttt atgcttgtca      300

tgttcgaagt ttgatacctt gcagatcaac aaagggccgg tggcctctca ctgcctccgc      360

ggcagggttg tcaagacatg cgcagtgcgg cccgtcccta gggctgggtt aa              412


<210> 2516
<211> 2867
<212> DNA
<213> Homo sapiens

<400> 2516
tccattccaa ataaaatcta taacaaatta ggtatagaaa gaatatacct caaaataaag       60

agatatgttc tttataagct ataggacaat cccatggtta acattattgt caatggtgaa      120

attttggaat tgtttttaag atttattata agaaaaagat gcccactctc actacttctt      180

tcaacaccgt attggaaatc ctgctcagaa tctaagacaa gagaaaaaag agcatttaaa      240

taagaaacaa caagttcttc tattcatgga gattaacgct caggtttttg cagattagat      300

ttaacagcat gaaatctggt accatccagg aatcaaagga tataggactt tagggcatca      360

attattaaga ggctatagga aagcagaaat gctcctggat gtttccattg tccacacaca      420

aaatttcaac agaccagccc caggaagtaa aggcacattc ctgactactg ttagttgatg      480

agcttttcac caaaagcaga gatgtgagac ctggcaggtt tcaaagaccc ctcaagtgct      540

ccataccttg aaattcactt ccacaaagct agaacaccat ctgttcctga gggatcaggt      600

tatcgtctgt ttcttttagg cactggtcag tcaggcttta gtggacacga agccacagat      660

ttttagtgta aaatgcctaa tctatcataa tctttaggta gatatttgga ggcctgcaca      720

cttaaatggg ttggtgaaat gtcataccag acacatggct gggaattggg tttttctcct      780

ccgctcttag cagcaccttt gtaacccagt gattaccccc ctcatggctc cacggccaca      840

tccgcaaaaa gggtactggt gaacgtgaca ttttcacgaa gccacagccc atggtcactc      900

cctgcaaagc tctgaacttg cgcattccca ggccaggccg tggttgtctt tccaaggcgg      960

ctcagcttgt gctttgcttg gagagagcgg agggcagcag cacagtgaca gcgtctggga     1020

cctcagacca gtttccacag ccacttatga aagcagacgg ctccatgggc tggaggaggt     1080

gggacgctct ggaaagaact cgggtgcgag tgggaaagaa aatcgagctg agcagctgga     1140

agtcgaagtc gcgtgagtga ggaccagaca ctctcgattt aggcaaaggc ggggtgcact     1200

tcccaacaac acatcctcct cactggcgag accaggcctg cccttcaagt tcctctcctg     1260

atttaatccc cttggcgagg gtttggcatg aaatcaatgg ccagcaagct tggtaaacga     1320

agccgcctac accgccctcc ccctccctgc acggccgcgc cccgcctccg ctcctgtctc     1380

aatctgggat tgtcctcctg tagccccacc atccaccgtg gggaacggtg gagagactac     1440

aactcccagt atgcaccgcg atgcgcgcct caccctgcat ctcccagccc gcagccagct     1500

ggcatcctag accctctgcc ctgcgaccaa cagccgggag cggaccagac accagaactc     1560

ccggaacggt tgaagacggt tccgctccct gtcccgcctt tcgcagccca gcagtttcgc     1620

cctgcggaga ggagccttgc tgtttccaaa tctctcctgc tgaagagaca ttggagctag     1680

ggcggctagt ttcacctggt aattgtgaca ccctgtctcc tcgagctgca ggcttttatg     1740

cttgtcatgt tcgaagtttg ataccttgca gatcaacaaa gggccggtgg cctctcactg     1800

cctccgcggc agggttgtca agtttttcag gttaagtact gcacgactac tcgcttctga     1860

aactgataga cactgcctca gctccgtgca gggcagacgc acaagagcag aatctccgtg     1920

ggacatctct ctggagcatc aatattactg cagtatttgg aagaaacaaa tttaaataag     1980

ttctaaggtg aagaatggaa catttaagac aagtctggaa agtcatctgc ctttaataac     2040

tgtcgtttgt ccttaacgtc agactttctc caagaccaaa actctaagaa cttatttcca     2100

ttcttacaaa tagtaaaaat gataaatcat atcaagtcaa ttgaaagtcc tgcctgctgc     2160

tttcctaaat tgcaatatgg ccttggtatg gttttatttg tacttttgtg ggggattcgt     2220

ggatctttag attaaaaaaa aaaaaatagg tttttgaaca atttttgcaa gtttgcagct     2280

gttagttatt gatttatttt tccaacccat ctaattcttc tgtctctctc ctctcctcag     2340

gctcaataat tccatgggtc tctaaggctg tgtttatttt ctttaaattt tgttgattta     2400

cttttatact ccatttgatt ttttctatct ctcacctttt ctcagactca gtcatcccac     2460

aggtctgtaa ggctctgttc attttcttta aacttctttt ttttttcctc tcctcagatt     2520

ggataaatta tattgctatg tctctgtttc tgaactatag aaaagctcaa aattattatt     2580

tttatttctc attttttata tggctatttt ttctctgctg atgtttcaca tctattcatt     2640

tatgagaata ttttcctttg ccctcatgag cgtgtttata atagctgcct tcaaattctt     2700

gtctgccgtt tacatcttgg acatcttgga gatggctact gcctgctttt tatcttgtgt     2760

atttattaca ttttcacgtg tcttcacgca tcccttgaat tggaaattgt gccctggaga     2820

ctgtatacaa gactggatta aaaagactgg attctgtttt gtccctg                   2867


<210> 2517
<211> 2983
<212> DNA
<213> Homo sapiens

<400> 2517
gataaatgcg gagggacggt ccagctttag ctctctgctc gccgccgccg ctgtcgccgc       60

cacctcctct gatctacgaa agtcatgtta cccaacaccg ggaggctggc aggatgtaca      120

gtttttatca caggtgcaag ccgtggcatt ggcaaagcta ttgcattgaa agcagcaaag      180

gatggagcaa atattgttat tgctgcaaag accgcccagc cacatccaaa acttctaggc      240

acaatctata ctgctgctga agaaattgaa gcagttggag gaaaggcctt gccatgtatt      300

gttgatgtga gagatgaaca gcagatcagt gctgcagtgg agaaagccat caagaaattt      360

ggagcttata ccattgctaa gtatggtatg tctatgtatg tgcttggaat ggcagaagaa      420

tttaaaggtg aaattgcagt caatgcatta tggcctaaaa cagccataca cactgctgct      480

atggatatgc tgggaggacc tggtatcgaa agccagtgta gaaaagttga tatcattgca      540

gatgcagcat attccatttt ccaaaagcca aaaagtttta ctggcaactt tgtcattgat      600

gaaaatatct taaaagaaga aggaatagaa aattttgacg tttatgcaat taaaccaggt      660

catcctttgc aaccagattt cttcttagat gaatacccag aagcagttag caagaaagtg      720

gaatcaactg gtgctgttcc agaattcaaa gaagagaaac tgcagctgca accaaaacca      780

cgttctggag ctgtggaaga aacatttaga attgttaagg actctctcag tgatgatgtt      840

gttaaagcca ctcaagcaat ctatctgttt gaactctccg gtgaagatgg tggcacgtgg      900

tttcttgatc tgaaaagcaa gggtgggaat gtcggatatg gagagccttc tgatcaggca      960

gatgtggtga tgagtatgac tactgatgac tttgtaaaaa tgttttcagg gaaactaaaa     1020

ccaacaatgg cattcatgtc agggaaattg aagattaaag gtaacatggc cctagcaatc     1080

aaattggaga agctaatgaa tcagatgaat gccagactgt gaaggaaaat ataaaaaaaa     1140

agtcgactgc tatgctcaaa aagtaaaaaa agctcaacag ttaaaatcta atgtttgttt     1200

tctttcctgt tatattataa ggatatgcac gtttgttctg gaaaagatag aatttgtctc     1260

taaaagactt gaaattgtaa ttaaaatggc aagctaatca aacataagct tcattaagtg     1320

ggattctaag acagtctgtg tttttatatt tcaagggttt aaccctttga gccttacatc     1380

tcattcactg tctttctcca agaaaagtat tttgggcgga cagtcagatc aagcagtaaa     1440

attagctctt tcaaatcttc ttgtcatgta aaatgaagct agtctgtttt aaaattttta     1500

gttttggatt gtatactaat gaaaatctta atgatgtttt tgatttttat atacttattt     1560

taaagaaaat cttatatagt acattttaca aaaattataa aaaatgaatt agtactggcg     1620

aggactaaat gaaacaataa tttttcattt tgataactag ctttccaggt ggacttagcc     1680

ataggaaaat attactaatg taatttaaca aattgctgca tgtattccat ttaaaaatat     1740

gtttaaattg tcctaaaaca aaataatttt ctccctagga gtatgcattt ggctacagtg     1800

ttttgaaaca gaaaccttag aataggtcat tggtatgggc tgaactgtgt atcccccaat     1860

tcatttgttg aggtcctaac tcccatttct tttgaatgtg actgttcgga gatgaggcct     1920

ttaaagaggt gacttaagtt caaaggaggc tgttagtcta atccaacatg gtgtcctttg     1980

gacataagag ataccagcaa tgtgtgcaca gaacaaagac caggagagga cacagtgaga     2040

aggcagttat ctgcaagcaa agagagaggc ttcagaagaa acaaaatcac cagcaccttg     2100

atctttgact tctaatctcc agaatagtga gaaataaatt tctgttgtta agccgtccac     2160

tgtgggaggc cgacgcagga ggattgcttg aggccaggag ttcaaggcca gcctggacaa     2220

catagtaaga ccctatctct acccccctaa taaattaatt taaaaagccc cccaatctgt     2280

ggtattttat tatggcagcc ctagcaagct aatacagtgg tttgagaggc tgggagggtt     2340

gaggggaaga taaactttta aaaagctctt atctttcatt tcaatcagtt aaaaatactt     2400

gctcagtgta acaattttgc ttctcagctt ccactctaat attgttgtgc cattaagcaa     2460

tttagctaat cctgacattt cttagattca taatgttagg agcatttaat ctgtatttta     2520

caagttagga agcagaggat cagagatggg aaaggactag cccaaggcca acattaacaa     2580

gccctctaac aaaaacttta caatacattt atgttgaatg gaactccaag atctcacctc     2640

tccatccagg aatggagtcc atgtaatcaa agtgaactta aaaataggac agtttcaaca     2700

agtcaggaga ttcacagcaa ctgatcaaag ggagtccagt caacgtgagc aagcgtgatt     2760

atgatgagga agccccctct gctttaatcc acacaaggaa cgtaacctga agtaacctga     2820

tgttaaccaa tctgctgtgt ctactatgct gtttccttgt tcctgctagt gctgctttac     2880

aaatgcagac cattctatca tacctggcgg ggcttctgtt ttattttgta ggctggatgc     2940

tacccagttc atgaatcgct aataaaagcc aattagatct tta                       2983


<210> 2518
<211> 3350
<212> DNA
<213> Homo sapiens

<400> 2518
agggaccagg cttgggaggc gacgaagagg aacgctgggc gcaggaggcc cactgcatac       60

gcaggcgcac tcggcgatcc cggcttttcc gcgcgcagtt cccgcacagg catcgggggg      120

ggcaggggcg gggcaggggc ggggataaat gcggagggac ggtccagctt tagctctctg      180

ctcgccgccg ccgctgtcgc cgccacctcc tctgatctac gaaagtcatg ttacccaaca      240

ccgggaggct ggcaggatgt acagttttta tcacaggtgc aagccgtggc attggcaaag      300

ctattgcatt gaaagcagca aaggatggag caaatattgt tattgctgca aagaccgccc      360

agccacatcc aaaacttcta ggcacaatct atactgctgc tgaagaaatt gaagcagttg      420

gaggaaaggc cttgccatgt attgttgatg tgagagatga acagcagatc agtgctgcag      480

tggagaaagc catcaagaaa tttggaggaa ttgatattct ggtaaataat gccagtgcca      540

ttagtttgac caatacattg gacacaccta ccaagagatt ggatctgatg atgaacgtga      600

acaccagagg cacctacctt gcatctaaag catgtattcc ttatttgaaa aagagcaaag      660

ttgctcatat cctcaatatc agtccaccac tgaacctaaa tccagtttgg ttcaaacagc      720

actgtgctta taccattgct aagtatggta tgtctatgta tgtgcttgga atggcagaag      780

aatttaaagg tgaaattgca gtcaatgcat tatggcctaa aacagccata cacactgctg      840

ctatggatat gctgggagga cctggtatcg aaagccagtg tagaaaagtt gatatcattg      900

cagatgcagc atattccatt ttccaaaagc caaaaagttt tactggcaac tttgtcattg      960

atgaaaatat cttaaaagaa gaaggaatag aaaattttga cgtttatgca attaaaccag     1020

gtcatccttt gcaaccagat ttcttcttag atgaataccc agaagcagtt agcaagaaag     1080

tggaatcaac tggtgctgtt ccagaattca aagaagagaa actgcagctg caaccaaaac     1140

cacgttctgg agctgtggaa gaaacattta gaattgttaa ggactctctc agtgatgatg     1200

ttgttaaagc cactcaagca atctatctgt ttgaactctc cggtgaagat ggtggcacgt     1260

ggtttcttga tctgaaaagc aagggtggga atgtcggata tggagagcct tctgatcagg     1320

cagatgtggt gatgagtatg actactgatg actttgtaaa aatgttttca gggaaactaa     1380

aaccaacaat ggcattcatg tcagggaaat tgaagattaa aggtaacatg gccctagcaa     1440

tcaaattgga gaagctaatg aatcagatga atgccagact gtgaaggaaa atataaaaaa     1500

aaagtcgact gctatgctca aaaagtaaaa aaagctcaac agttaaaatc taatgtttgt     1560

tttctttcct gttatattat aaggatatgc acgtttgttc tggaaaagat agaatttgtc     1620

tctaaaagac ttgaaattgt aattaaaatg gcaagctaat caaacataag cttcattaag     1680

tgggattcta agacagtctg tgtttttata tttcaagggt ttaacccttt gagccttaca     1740

tctcattcac tgtctttctc caagaaaagt attttgggcg gacagtcaga tcaagcagta     1800

aaattagctc tttcaaatct tcttgtcatg taaaatgaag ctagtctgtt ttaaaatttt     1860

tagttttgga ttgtatacta atgaaaatct taatgatgtt tttgattttt atatacttat     1920

tttaaagaaa atcttatata gtacatttta caaaaattat aaaaaatgaa ttagtactgg     1980

cgaggactaa atgaaacaat aatttttcat tttgataact agctttccag gtggacttag     2040

ccataggaaa atattactaa tgtaatttaa caaattgctg catgtattcc atttaaaaat     2100

atgtttaaat tgtcctaaaa caaaataatt ttctccctag gagtatgcat ttggctacag     2160

tgttttgaaa cagaaacctt agaataggtc attggtatgg gctgaactgt gtatccccca     2220

attcatttgt tgaggtccta actcccattt cttttgaatg tgactgttcg gagatgaggc     2280

ctttaaagag gtgacttaag ttcaaaggag gctgttagtc taatccaaca tggtgtcctt     2340

tggacataag agataccagc aatgtgtgca cagaacaaag accaggagag gacacagtga     2400

gaaggcagtt atctgcaagc aaagagagag gcttcagaag aaacaaaatc accagcacct     2460

tgatctttga cttctaatct ccagaatagt gagaaataaa tttctgttgt taagccgtcc     2520

actgtgggag gccgacgcag gaggattgct tgaggccagg agttcaaggc cagcctggac     2580

aacatagtaa gaccctatct ctacccccct aataaattaa tttaaaaagc cccccaatct     2640

gtggtatttt attatggcag ccctagcaag ctaatacagt ggtttgagag gctgggaggg     2700

ttgaggggaa gataaacttt taaaaagctc ttatctttca tttcaatcag ttaaaaatac     2760

ttgctcagtg taacaatttt gcttctcagc ttccactcta atattgttgt gccattaagc     2820

aatttagcta atcctgacat ttcttagatt cataatgtta ggagcattta atctgtattt     2880

tacaagttag gaagcagagg atcagagatg ggaaaggact agcccaaggc caacattaac     2940

aagccctcta acaaaaactt tacaatacat ttatgttgaa tggaactcca agatctcacc     3000

tctccatcca ggaatggagt ccatgtaatc aaagtgaact taaaaatagg acagtttcaa     3060

caagtcagga gattcacagc aactgatcaa agggagtcca gtcaacgtga gcaagcgtga     3120

ttatgatgag gaagccccct ctgctttaat ccacacaagg aacgtaacct gaagtaacct     3180

gatgttaacc aatctgctgt gtctactatg ctgtttcctt gttcctgcta gtgctgcttt     3240

acaaatgcag accattctat catacctggc ggggcttctg ttttattttg taggctggat     3300

gctacccagt tcatgaatcg ctaataaaag ccaattagat ctttacataa                3350


<210> 2519
<211> 1566
<212> DNA
<213> Homo sapiens

<400> 2519
acaaagcggt tggttgcggc agggactaca ccggtgtatc atgggagcgg cccgggctac       60

acgttaaaaa cactaagggg agcgcgcgaa gctgaacttg gcgctcgatg ggggccgtta      120

gccgccctag agcgcgcgga gccgcagagg cgtagctgga ctacaacgca gtgcatctcg      180

ggaggccaac tcgactggac tgggtgagag gacagaggtg gctcgatggg cggcccgaag      240

gccggggatc atggcgggaa ggcgggccca gacaggttca gccccgcccc gacccgccgc      300

tccccacccc ccggccggcc tcgcgtgcct tcccgcagca ctgccgtccc cgggatgctg      360

agcgcccacc gtctccccgc agccccctca tgcccggctg cgagctgccc gtgggcacct      420

gcccggacat gtgcccggcc gccgagcgcg cccagcgcga aagggagcac cgcctgcacc      480

gcttggaggt ggtgccgggt tgccgccagg acccgccccg cgcggatccg cagcgcgcgg      540

tgaaggagta cagccgaccc gccgccggca agccccggcc cccgcccagc cagttgcgtc      600

cgccctccgt gctgctggcc accgtgcgct acctggccgg tgaggtggcg gagagcgccg      660

acatcgcccg cgccgaggtg gccagcttcg tggcagaccg cttgcgagct gtgctcctgg      720

acctggcgct gcagggagcg ggcgacgccg aggcagctgt ggtgctggag gcggcgctgg      780

ccacgctgct gaccgtagtg gcgcggctcg ggcccgacgc ggcgcgggga cccgcggacc      840

cggtgctgct gcaggcccag gtgcaggagg gcttcggctc gctgcggcgc tgctacgcgc      900

ggggcgccgg gccgcacccc cgccaacccg ccttccaggg cctctttctg ctctataacc      960

tgggctcggt ggaagccctg catgaggttc tacagctgcc tgctgccctg cgcgcctgcc     1020

cgcccctccg caaggccttg gcggtagatg ctgccttccg agagggcaat gctgcccgcc     1080

tgttccgtct gctccagacc ctgccctacc tgccaagttg cgctgtgcag tgccatgtgg     1140

gccatgcccg ccgggaagcc ctggcccgct tcgctcgtgc ctttagcacc cccaagggcc     1200

agaccttgcc tctgggcttc atggtcaacc tcttggccct ggatggactc agggaagcac     1260

gggacctgtg ccaggcccac gggctgccct tggacggaga ggagagagtt gtgttcctga     1320

ggggtcgcta cgtggaggaa gggctaccgc ctgccagtac gtgcaaggtg ttagtggaga     1380

gcaaacttcg aggacgtacc ctggaggagg tggtcatggc agaggaggaa gatgagggca     1440

cggacagacc tgggtcccca gcctgaggag ggagcgtgag cctcccagag ccccaggact     1500

gggccagagc acttaggttt ctttttccat ggtttccagg taataaaagg aacttgtttt     1560

gttggt                                                                1566


<210> 2520
<211> 393
<212> DNA
<213> Homo sapiens

<400> 2520
gagccgagcc gagccgagct gggggcgcag agcgcgggag gcggcggcgg cgcggagccc       60

agatggagtt tccctcttgt tgcccgagcc agagtacagt ggtgtgatct cggttcactg      120

caacctctgc ctcccaggtt caagcgattc tcctgcctca gcctcccgag tggctgggat      180

tacaggtggc tccgctgccg gatgggagtg ccccagtgtg ctggatgaag ctggcgcatg      240

caccatgtca tcatgtgtct ctagccagcc cagcagcaac cgggccgccc cccaggatga      300

gctggggggc aggggcagca gcagcagcga aagccagaag ccctgtgagg ccctgcgggg      360

cctctcatcc ttgagcatcc acctgggcat gga                                   393


<210> 2521
<211> 6072
<212> DNA
<213> Homo sapiens

<400> 2521
agaaaggaaa aaagacaacg aggaaaaagg aggtgtccgg gtagggcaac gcggcgacac       60

ccgaggcctg gtggtggcgg cggatcgaga tattcaaggc tgaagcagct acggaacggc      120

agcggcggcg gtcggacaaa ctgactgacc gagccgggtg gtggcgggag cagcgggagc      180

agccggaacg atgccggccg tgagcctccc gcccaaggag aatgcgctct tcaagcggat      240

cttgaggtgt tatgaacata aacagtatag aaatggattg aaattctgta aacaaatact      300

ttctaatccc aaatttgcag agcatggaga aaccttggct atgaaaggat taacattgaa      360

ctgtttgggg aaaaaggaag aagcttatga attggttcgt agaggtttga gaaatgactt      420

gaagagtcat gtgtgttggc acgtttatgg ccttcttcag aggtcagaca agaagtatga      480

tgaagccatt aagtgttaca gaaatgcact aaaatgggat aaagacaatc ttcaaatctt      540

aagggacctt tccttactac agattcaaat gcgagatctt gagggttaca gggaaacgag      600

gtatcagtta cttcagcttc gacctgcgca gagagcatca tggattggtt atgctattgc      660

ttaccattta ttagaagatt atgaaatggc agcaaagatt ttagaagaat ttaggaaaac      720

acaacagaca tcccctgaca aggtggatta tgaatatagt gaactactct tatatcagaa      780

tcaagttctt cgggaagcag gtctctatag agaagctttg gaacatcttt gtacctatga      840

aaagcagatt tgtgataaac ttgctgtaga agaaaccaaa ggggaacttc tgttgcaact      900

atgtcgtttg gaagatgctg cagatgttta tagaggattg caagagagaa atcctgaaaa      960

ctgggcctat tacaaaggct tggaaaaagc actcaagcca gctaatatgt tagaacggct     1020

aaaaatttat gaggaagcct ggactaaata tcccagggga ctggtgccaa gaaggctgcc     1080

gttaaacttt ttatctggtg agaagtttaa agaatgtttg gataagttcc taaggatgaa     1140

tttcagcaag ggttgcccac cagtcttcaa tactttaaga tcattataca aagacaaaga     1200

aaaggtggca atcatagaag agttagtagt aggttatgaa acctctctaa aaagctgccg     1260

gttatttaac cccaatgatg atggaaagga ggaaccacca accacattac tttgggtcca     1320

gtactacttg gcacaacatt atgacaaaat tggtcagcca tctattgctt tggagtacat     1380

aaatactgct attgaaagta cacctacatt aatagaactc tttctcgtga aagctaaaat     1440

ctataagcat gctggaaata ttaaagaagc tgcaaggtgg atggatgagg cccaggcctt     1500

ggacacagca gacagattta tcaactccaa atgtgcaaaa tacatgctaa aagccaacct     1560

gattaaagaa gctgaagaaa tgtgctcaaa gtttacaagg gaaggaacat cagcggtaga     1620

gaatttgaat gaaatgcagt gcatgtggtt ccaaacagaa tgtgcccagg cttataaagc     1680

aatgaataaa tttggtgaag cacttaagaa atgtcatgag attgagagac attttataga     1740

aatcactgat gaccagtttg actttcatac atactgtatg aggaagatta cccttagatc     1800

atatgtggac ttattaaaac tagaagatgt acttcgacag catccatttt acttcaaggc     1860

agcaagaatt gctatagaga tctatttgaa gcttcatgac aaccccctta cagatgagaa     1920

taaagaacac gaagctgata cagcaaacat gtctgacaaa gagctaaaga agctacgtaa     1980

taaacaaaga agagctcaaa agaaagccca gatagaagaa gagaaaaaaa atgcagaaaa     2040

agaaaagcag cagagaaatc agaaaaagaa gaaggatgat gatgatgagg agataggagg     2100

tccaaaagaa gaacttattc cagagaaact ggccaaggtt gaaactccat tggaagaagc     2160

tattaaattt ttaacaccgt tgaagaactt ggtgaagaac aagatagaga ctcatctttt     2220

tgcctttgag atttacttta ggaaagaaaa gtttcttttg atgctacaat cagtaaagag     2280

ggcatttgct attgattcta gtcatccctg gcttcatgag tgtatgattc gtctctttaa     2340

tactgtgtgt gaaagtaaag atttatctga tacagttaga acagtattaa aacaagaaat     2400

gaatcgtctt tttggagcaa cgaatccaaa gaattttaat gaaacttttc tgaaaaggaa     2460

ttctgattca ttgccacaca gattatcagc tgccaaaatg gtatattact tagatccttc     2520

tagtcagaag cgagctatag agttggcaac aacacttgat gaatctctca ctaacagaaa     2580

cctccagaca tgtatggagg tattggaagc cttgtatgat ggtagcctag gagactgtaa     2640

agaagctgct gaaatttata gagcaaattg tcataagctt ttcccttatg ctttggcttt     2700

catgcctcct ggatatgaag aggatatgaa gatcacagtt aatggagata gttctgcaga     2760

agctgaagaa ctggccaatg aaatttgaac atcactaaac aagcaaatgg aatgactttg     2820

gaccatatct agtatataat atttttgtca cgcacctgct gcattgctct aacttacaca     2880

gaatgagagg agtaaatgtt cttgccttca aatagtgttt tacgtttttt atcctgctga     2940

aaaagtatat ataaaatatc taacattaca ggatagaggt tcagtttctt aaaaaattaa     3000

agctgctaaa attgagtggt taaaaaagat accttatcct attcctcccc acccacccat     3060

gtttttaaac taatttatat aaaatctgga ggctgttaca gctaacaaag caggtgtgtg     3120

gcagaaatat tactttaaat ttgtcttgtg agattttact atatctcaga cagcataaat     3180

gctgttttag cactggattc tttcactgag cacaaagagt tgttggggct ttagcatctg     3240

actgattttg ttacggggtt gattctgacc ataggaagta tgcaatgtga atcactattt     3300

acagagaaac ctacaacaga tgcttgatgt tgtagaaact gggacatata gataccaagc     3360

aaaattataa gaaacctata aggtgttcaa tacgcttgtg tttccaaaat tcactgtaca     3420

tgatcagttt ggtgttcttg taccacagtt tttaactgaa ggaaccagtt gtaacagtct     3480

caattttaac taaaacttga agaactaaaa caacaatgca aacctttcag cattgtttgg     3540

ccaaacttgt taaaactgta atgcaagaac caaatgcact gtgatgtggc accaactaat     3600

tagcaagcat gaatttttca cccaagagtg aaaaaaggaa aatctaccat ggcttgaagt     3660

taaagagcag aactcctgac taccattcta tgactgatca aaagactaat agttaaaaac     3720

ctcagcaggc cttgttcacg atatgcagaa aaaaaagtgc tgcagtttag atacctctgg     3780

aatttttcca cagtgtcaca ggtttgtaat acttgaagcc ctacatttct aagaatatat     3840

ttcttgctca gttgtttcag gcaagcccaa gactttgtaa tttttaaagg gcccaagatt     3900

tttttttttt tttttttttt caaataacag accagcttct ttttcttgca gttacagatg     3960

taatttcctt tttgttgtca aacataaggt accaaatatg atgcaataaa ttgttttgaa     4020

aaacagttgt gtgaatattt caactaatct gtgttgggct tctgtgaaat acacaggtgg     4080

aaacagaggt gcaagccaga ggcaatgtaa tatgctgtaa ggctagtgca gatgggagct     4140

ttttagaagg ggctaagtgc tggtgtcagg gaaattccat aatgaagtag aatgctgctc     4200

ctgcattaag atttcattga gggcaaggct ggtggcaggt actatgaatg taattcataa     4260

tttaaaagga aaactaaaaa ctattttgat ttgggaaaat gagccttaat ttgttaaacc     4320

tatacactga gaactagcct caggcttaat attctcattg catttgcaag atctgagcaa     4380

ataagattaa gtaaaacaaa tcaattgtat atataattga cctttttgtg gaacatgtag     4440

tttatagaaa gtatactcta aagggaattt gccgaagacc ttttactgat tgaacagttg     4500

tgctacaatc aacttttcat agtacatgac ctgcattcca catctcagtc taacagttta     4560

gtagtgatgt aaagagaagt acaaaccgaa ctccagtgct ttgttatgtt ttattaactg     4620

gccctgtctc aggaacatct taacagatgg caaaaaaaca aaaacttttt ttcaactcct     4680

atgagtggca actgaagttc ttattgttgg gaaagaacac tagtcctacc tctgccacta     4740

atgaggtgtt tggaggaggt accagccata taataggggg tgtatgtgtg aattttgttt     4800

aaactctact gtatattgaa atgaaattca tttatttgtc ttgacaatgt tcaaatgatg     4860

tagattgtct tagaatgaat attcataagt actcagaact cttaagatgc agatgccacc     4920

cgtgaggagc taaattccta atgtgtattg tattccaacc caattttact ggaactattg     4980

aataaatctt ttattttctt tcaggtttac ttgatagtgg atacattggt gtcagaggac     5040

cttgactggg ttcattttat gtccagacat cacccctgaa acactgtact gtactatctt     5100

gctctgagta gtatcaactg gatcgtctca tatttgcctc attcatccta ttaatttcaa     5160

atgatactgt gggggaaaaa cagggttaga aaaacaagtg gaaaaaatgg agtgatgttg     5220

taatctaaac aagtgcctta tgtttattgc taagaactgg tgttaccaac ccttttgaga     5280

agaaagggtc tcttgacctg tattaacata ggaaagtaaa gttctttttg tttttcttta     5340

tattcagcta ctcttgtcat ttctcgttga aaaactaaaa tctgactagg ttagtttact     5400

cagctttaat tagatagttg agtcatatat tttcaacatt tttctgtatc gtatttatta     5460

tgcacaaaaa taaagtgtga tctctaatag catggctaaa ggtaatgcca atattagtga     5520

atagctttgc tgtgggcttt atcaggccct tgtttttcac agtgttgttt gtactccatg     5580

gtgtattgct attagagctg tgaaatgaaa gctgtgactt tatgaagaga tcaaaaaaag     5640

tgtggtccag attcaggtag gttgtggtaa gttcagggaa gtcttgtatg atttctaaga     5700

atatttcagt taccatgtat agtatttggg aaaagctgta atgtaaaata ttggactttg     5760

ttgcaagata ggtatatact tgtgtcagat aattaaagcc ttaaattttg aaatgaatct     5820

ttgagatttc aaagaaagac tgacctttca aatagaaggc ggtctttcta ttctagctaa     5880

tgccccactt ctttaagtta taaacaaagt ttcatgatac cattctgcta tcatctaaac     5940

tttgctgaac tctactgcca acctacatta aaaacaaagt cccacgaaat ggctgtgtta     6000

caccatagtg agcagaaact taaattttgt tctaattttg atggttgaaa aatttcaacc     6060

tgtagcaata aa                                                         6072


<210> 2522
<211> 2309
<212> DNA
<213> Homo sapiens

<400> 2522
cgcggcccca agcggttccc gagcccaggc ccgcgccgag cccaggtcct agagcagctc       60

cagcaggatg gcggctccag cgtctctaag gcctgcaggg ggtccagccc catggggggc      120

gccctaggcc tccgacagct ccccatctgt gctcctgcct gccggccatc ctcaggccac      180

tcgccatggg cggctgcttc tccaaaccca aaccagtgga gctcaagatc gaggtggtgc      240

tgcctgagaa ggagcgaggc aaggaggagc tgtcggccag tgggaagggc agcccccggg      300

cctaccaggg caatggcacg gcccgccact tccacacgga ggagcgcctg tccacccctc      360

acccctaccc cagccctcag gattgcgtgg aggctgctgt ctgccacgtc aaggacctcg      420

agaatggcca gatgcgggaa gtggagctgg gctgggggaa ggtgttgctg gtgaaggaca      480

atggggagtt ccacgccctg ggccataagt gtccgcacta cggcgcaccc ctggtgaaag      540

gcgttctgtc ccgtggtcgg gtgcgctgcc cctggcacgg cgcctgcttc aacatcagca      600

ctggggacct ggaggacttc cctggcctgg acagtctaca caagttccag gtgaagattg      660

agaaggagaa ggtgtacgtc cgggccagca agcaggccct acagctgcag cgaaggacca      720

aggtgatggc caagtgtatc tctccaagtg ctgggtacag cagtagcacc aatgtgctca      780

ttgtgggtgc aggtgcagct ggcctggtgt gtgcagagac actgcggcag gagggcttct      840

ccgaccggat cgtcctgtgc acgctagacc ggcaccttcc ctacgaccgt cccaagctca      900

gcaagtccct ggacacacag cctgagcagc tggccctgag gcccaaggag tttttccgag      960

cctatggcat cgaggtgctc accgaggctc aggtggtcac agtggacgtg agaactaaga     1020

aggtcgtgtt caaggatggc ttcaagctgg agtacagcaa gctgctgctg gcaccaggga     1080

gcagccccaa gactctgagc tgcaaaggca aagaagtgga gaacgtgttc actatccgga     1140

cgccagagga tgccaatcgc gtggtgaggc tggcccgagg ccgcaacgtg gtcgtcgtgg     1200

gagccggctt cctggggatg gaggtggccg cttacctgac ggagaaggcc cactctgtgt     1260

ctgtggtgga gctggaggag acgcccttca ggaggttcct gggggagcgc gtgggtcgag     1320

ccctcatgaa gatgtttgag aacaaccggg tgaagttcta catgcagacg gaggtgtctg     1380

agctgcgggg ccaggaggga aagctgaagg aggttgtgct gaagagcagc aaggtcgtgc     1440

gggctgacgt ctgcgtggtg ggcattggtg cagtgcccgc cacaggcttc ctgaggcaaa     1500

gcggcatcgg tttggattcc cgaggcttca tccctgtcaa caagatgatg cagaccaatg     1560

tcccaggcgt gtttgcagct ggcgatgctg tcaccttccc ccttgcctgg aggaacaacc     1620

gcaaagtgaa cattccacat tggcagatgg ctcatgctca ggggcgcgtg gcagcccaga     1680

acatgttggc gcaggaggcg gagatgagca ctgtgcccta cctctggacc gccatgtttg     1740

gcaagagcct gcgctacgcg ggctacggag aaggcttcga cgacgtcatc atccaggggg     1800

atctggagga gctgaagttt gtggcttttt acactaaagg cgacgaggtg atcgccgtgg     1860

ccagcatgaa ctacgatccc attgtgtcca aggtcgctga ggtgctggcc tcaggccgtg     1920

ccatccggaa gcgggaggtg gagactggcg acatgtcctg gcttacgggg aaaggatcct     1980

gagctcacat gcagtagact tgggcaggca aagggggcac caagggcaca ggccaagcct     2040

tgggggcagg tgccaatctc cagtcccagg atcccccagg gcagaacctg agccctccca     2100

gtgcttgcct tcagccacct ggctcccctc ctgggaggcc tctgctggat ccagaagatg     2160

ctcaaccctc aaggcctctg ctgccactga cagctggcac tggaggcagg acaagccctg     2220

cctcttctcc ctctattggg actggtcccc tgaagaaccc tgcaacacgt taaacattac     2280

cgtaaaatta aaacgcacaa atttgcaga                                       2309


<210> 2523
<211> 2387
<212> DNA
<213> Homo sapiens

<400> 2523
agtgcaaacg cagcgccaga cacgccccgc ccgcgcctcc ccgccccccc gcgcccgcgg       60

ccccaagcgg ttcccgagcc caggcccgcg ccgagcccag gtcctagagc agctccagca      120

ggatggcggc tccagcgtct ctaaggcctg cagggggtcc agccccatgg ggggcgccct      180

aggcctccga cagctcccca tctgtgctcc tgcctgccgg ccatcctcag gccactcgcc      240

atgggcggct gcttctccaa acccaaacca gtggagctca agatcgaggt ggtgctgcct      300

gagaaggagc gaggcaagga ggagctgtcg gccagtggga agggcagccc ccgggcctac      360

cagggcaatg gcacggcccg ccacttccac acggaggagc gcctgtccac ccctcacccc      420

taccccagcc ctcaggattg cgtggaggct gctgtctgcc acgtcaagga cctcgagaat      480

ggccagatgc gggaagtgga gctgggctgg gggaaggtgt tgctggtgaa ggacaatggg      540

gagttccacg ccctgggcca taagtgtccg cactacggcg cacccctggt gaaaggcgtt      600

ctgtcccgtg gtcgggtgcg ctgcccctgg cacggcgcct gcttcaacat cagcactggg      660

gacctggagg acttccctgg cctggacagt ctacacaagt tccaggtgaa gattgagaag      720

gagaaggtgt acgtccgggc cagcaagcag gccctacagc tgcagcgaag gaccaaggtg      780

atggccaagt gtatctctcc aagtgctggg tacagcagta gcaccaatgt gctcattgtg      840

ggtgcaggtg cagctggcct ggtgtgtgca gagacactgc ggcaggaggg cttctccgac      900

cggatcgtcc tgtgcacgct agaccggcac cttccctacg accgtcccaa gctcagcaag      960

tccctggaca cacagcctga gcagctggcc ctgaggccca aggagttttt ccgagcctat     1020

ggcatcgagg tgctcaccga ggctcaggtg gtcacagtgg acgtgagaac taagaaggtc     1080

gtgttcaagg atggcttcaa gctggagtac agcaagctgc tgctggcacc agggagcagc     1140

cccaagactc tgagctgcaa aggcaaagaa gtggagaacg tgttcactat ccggacgcca     1200

gaggatgcca atcgcgtggt gaggctggcc cgaggccgca acgtggtcgt cgtgggagcc     1260

ggcttcctgg ggatggaggt ggccgcttac ctgacggaga aggcccactc tgtgtctgtg     1320

gtggagctgg aggagacgcc cttcaggagg ttcctggggg agcgcgtggg tcgagccctc     1380

atgaagatgt ttgagaacaa ccgggtgaag ttctacatgc agacggaggt gtctgagctg     1440

cggggccagg agggaaagct gaaggaggtt gtgctgaaga gcagcaaggt cgtgcgggct     1500

gacgtctgcg tggtgggcat tggtgcagtg cccgccacag gcttcctgag gcaaagcggc     1560

atcggtttgg attcccgagg cttcatccct gtcaacaaga tgatgcagac caatgtccca     1620

ggcgtgtttg cagctggcga tgctgtcacc ttcccccttg cctggaggaa caaccgcaaa     1680

gtgaacattc cacattggca gatggctcat gctcaggggc gcgtggcagc ccagaacatg     1740

ttggcgcagg aggcggagat gagcactgtg ccctacctct ggaccgccat gtttggcaag     1800

agcctgcgct acgcgggcta cggagaaggc ttcgacgacg tcatcatcca gggggatctg     1860

gaggagctga agtttgtggc tttttacact aaaggcgacg aggtgatcgc cgtggccagc     1920

atgaactacg atcccattgt gtccaaggtc gctgaggtgc tggcctcagg ccgtgccatc     1980

cggaagcggg aggtggagct gtttgtgctg cacagcaaga ctggcgacat gtcctggctt     2040

acggggaaag gatcctgagc tcacatgcag tagacttggg caggcaaagg gggcaccaag     2100

ggcacaggcc aagccttggg ggcaggtgcc aatctccagt cccaggatcc cccagggcag     2160

aacctgagcc ctcccagtgc ttgccttcag ccacctggct cccctcctgg gaggcctctg     2220

ctggatccag aagatgctca accctcaagg cctctgctgc cactgacagc tggcactgga     2280

ggcaggacaa gccctgcctc ttctccctct attgggactg gtcccctgaa gaaccctgca     2340

acacgttaaa cattaccgta aaattaaaac gcacaaattt gcagatc                   2387


<210> 2524
<211> 1923
<212> DNA
<213> Homo sapiens

<400> 2524
tgctgcgtgg aaccgccgag ttcccagcgc ttgagaagga aaattctgga tctgttatct       60

gtgaggaggc cactccgttg acagttgtgt aaaactctgc tgctttcccc agctccaacc      120

tctctggtct tcaacaacac tatcatcagg gaaaacgtgg gggaagatga accagccgtg      180

caactcgatg gagccgaggg tgatggacga tgacatgctc aagctggccg tcggggacca      240

gggcccccag gaggaggccg ggcagctggc caagcaggag ggcatcctct tcaaggatgt      300

cctgtccctg cagctggact ttcggaacat cctccgcata gacaacctct ggcagtttga      360

gaacttgagg aagctgcagc tggacaataa catcattgag aagatcgagg gcctggagaa      420

cctcgcacac ctggtctggc tggatctgtc tttcaacaac attgagacca tcgaggggct      480

ggacacactg gtgaacctgg aggacctgag cttgttcaac aaccggatct ccaagatcga      540

ctccctggac gccctcgtca agctgcaggt gttgtcgctg ggcaacaacc ggattgacaa      600

catgatgaac atcatctacc tccggcggtt caagtgcctg cggacgctca gcctctctag      660

gaaccctatc tctgaggcag aggattacaa gatgttcatc tgtgcctacc ttcctgacct      720

catgtacctg gactaccggc gcattgatga ccacacaaaa aagcttgcgg aggctaagca      780

ccagtacagc atcgacgagc tgaagcacca ggagaacctg atgcaggccc agctggagga      840

cgagcaggcg cagcgggagg agctagagaa gcacaagact gcgtttgtgg aacacctgaa      900

tggctccttc ctgtttgaca gcatgtacgc tgaggactca gagggcaaca atctgtccta      960

cctgcctggt gtcggtgagc tccttgagac ctacaaggac aagtttgtca tcatctgcgt     1020

gaatattttt gagtatggcc tgaaacagca ggagaagcgg aaaacagagc ttgacacctt     1080

cagtgaatgt gtccgtgagg ccatccagga aaaccaggag cagggcaaac gcaagattgc     1140

caaattcgag gagaagcact tgtcgagttt aagtgccatt cgagaggagt tggaactgcc     1200

caacattgag aagatgatcc tagaatgcag tgctgacatc agtgagttgt tcgatgcgct     1260

catgacgctg gagatgcagc tggtggagca gctggaggag actataaaca tgtttgaaag     1320

gaacattgtt gacatggtag gactgtttat cgaaaatgtc caaagcctga tggctcagtg     1380

ccgggacctg gagaatcacc accacgagaa gctcctggag atctctatca gcaccctgga     1440

gaagattgtc gagggcgacc tggacgagga cctgcctaac gacctgcgcg cgggtcgttt     1500

ccaaaagttc aattatgtgg aggcttctgg cactttctaa gagaagcagt tacaggtaga     1560

ggttgaagtc tgagatttcc cctggaggtc ttcttaacct tagagtctgt ataatgagta     1620

ctgtgggggt gttggaacca ccatttctga tcctgcacaa tgccatccgg tttgcaccag     1680

cacatccact gatgaatggt cacaaaatca gcagggtcgg cctgaggaac ctggctccat     1740

ccctggggtc tgcacgctaa gaaggctctc ccggatgtct gcgctgggtc ccgcggcagc     1800

atgtctatgt ctctggaagg agtgtgggca tcaagggccc agacagagat actatgttgt     1860

cagggcccag acagagatac tatgttgtca gggcctgctt tagtgcatgc atcattcact     1920

cca                                                                   1923


<210> 2525
<211> 2046
<212> DNA
<213> Homo sapiens

<400> 2525
gtgtttcacc acacggagat gtggtcacgt gacttgtcaa ctttcaccca ggatgtctcc       60

cttctgactt ccccttagca accaagtcgc ggcgcttggt tccccagcaa ccgggagacg      120

cgtctgctgc gtggaaccgc cgagttccca gcgcttgaga aggaaaattc tggatctgtt      180

atctgtgagg aggccactcc gttgacagtt gtgtaaaact ctgctgcttt ccccagctcc      240

aacctctctg gtcttcaaca acactatcat cagggaaaac gtgggggaag atgaaccagc      300

cgtgcaactc gatggagccg agggtgatgg acgatgacat gctcaagctg gccgtcgggg      360

accagggccc ccaggaggag gccgggcagc tggccaagca ggagggcatc ctcttcaagg      420

atgtcctgtc cctgcagctg gactttcgga acatcctccg catagacaac ctctggcagt      480

ttgagaactt gaggaagctg cagctggaca ataacatcat tgagaagatc gagggcctgg      540

agaacctcgc acacctggtc tggctggatc tgtctttcaa caacattgag accatcgagg      600

ggctggacac actggtgaac ctggaggacc tgagcttgtt caacaaccgg atctccaaga      660

tcgactccct ggacgccctc gtcaagctgc aggtgttgtc gctgggcaac aaccggattg      720

acaacatgat gaacatcatc tacctccggc ggttcaagtg cctgcggacg ctcagcctct      780

ctaggaaccc tatctctgag gcagaggatt acaagatgtt catctgtgcc taccttcctg      840

acctcatgta cctggactac cggcgcattg atgaccacac aaaaaagctt gcggaggcta      900

agcaccagta cagcatcgac gagctgaagc accaggagaa cctgatgcag gcccagctgg      960

aggacgagca ggcgcagcgg gaggagctag agaagcacaa gactgcgttt gtggaacacc     1020

tgaatggctc cttcctgttt gacagcatgt acgctgagga ctcagagggc aacaatctgt     1080

cctacctgcc tggtgtcggt gagctccttg agacctacaa ggacaagttt gtcatcatct     1140

gcgtgaatat ttttgagtat ggcctgaaac agcaggagaa gcggaaaaca gagcttgaca     1200

ccttcagtga atgtgtccgt gaggccatcc aggaaaacca ggagcagggc aaacgcaaga     1260

ttgccaaatt cgaggagaag cacttgtcga gtttaagtgc cattcgagag gagttggaac     1320

tgcccaacat tgagaagatg atcctagaat gcagtgctga catcagtgag ttgttcgatg     1380

cgctcatgac gctggagatg cagctggtgg agcagctgga ggagactata aacatgtttg     1440

aaaggaacat tgttgacatg gtaggactgt ttatcgaaaa tgtccaaagc ctgatggctc     1500

agtgccggga cctggagaat caccaccacg agaagctcct ggagatctct atcagcaccc     1560

tggagaagat tgtcgagggc gacctggacg aggacctgcc taacgacctg cgcgcgggtc     1620

gtttccaaaa gttcaattat gtggaggctt ctggcacttt ctaagagaag cagttacagg     1680

tagaggttga agtctgagat ttcccctgga ggtcttctta accttagagt ctgtataatg     1740

agtactgtgg gggtgttgga accaccattt ctgatcctgc acaatgccat ccggtttgca     1800

ccagcacatc cactgatgaa tggtcacaaa atcagcaggg tcggcctgag gaacctggct     1860

ccatccctgg ggtctgcacg ctaagaaggc tctcccggat gtctgcgctg ggtcccgcgg     1920

cagcatgtct atgtctctgg aaggagtgtg ggcatcaagg gcccagacag agatactatg     1980

ttgtcagggc ccagacagag atactatgtt gtcagggcct gctttagtgc atgcatcatt     2040

cactcc                                                                2046


<210> 2526
<211> 2014
<212> DNA
<213> Homo sapiens

<400> 2526
gagacagggt cttcctatgt tgcccgggct ggtcttgaac tcctgaactc aagcagtcct       60

tccacctcgg cctcccaaag agctgggatt acaggtgaaa attctggatc tgttatctgt      120

gaggaggcca ctccgttgac agttgtgtaa aactctgctg ctttccccag ctccaacctc      180

tctggtcttc aacaacacta tcatcaggga aaacgtgggg gaagatgaac cagccgtgca      240

actcgatgga gccgagggtg atggacgatg acatgctcaa gctggccgtc ggggaccagg      300

gcccccagga ggaggccggg cagctggcca agcaggaggg catcctcttc aaggatgtcc      360

tgtccctgca gctggacttt cggaacatcc tccgcataga caacctctgg cagtttgaga      420

acttgaggaa gctgcagctg gacaataaca tcattgagaa gatcgagggc ctggagaacc      480

tcgcacacct ggtctggctg gatctgtctt tcaacaacat tgagaccatc gaggggctgg      540

acacactggt gaacctggag gacctgagct tgttcaacaa ccggatctcc aagatcgact      600

ccctggacgc cctcgtcaag ctgcaggtgt tgtcgctggg caacaaccgg attgacaaca      660

tgatgaacat catctacctc cggcggttca agtgcctgcg gacgctcagc ctctctagga      720

accctatctc tgaggcagag gattacaaga tgttcatctg tgcctacctt cctgacctca      780

tgtacctgga ctaccggcgc attgatgacc acacaaaaaa gcttgcggag gctaagcacc      840

agtacagcat cgacgagctg aagcaccagg agaacctgat gcaggcccag ctggaggacg      900

agcaggcgca gcgggaggag ctagagaagc acaagactgc gtttgtggaa cacctgaatg      960

gctccttcct gtttgacagc atgtacgctg aggactcaga gggcaacaat ctgtcctacc     1020

tgcctggtgt cggtgagctc cttgagacct acaaggacaa gtttgtcatc atctgcgtga     1080

atatttttga gtatggcctg aaacagcagg agaagcggaa aacagagctt gacaccttca     1140

gtgaatgtgt ccgtgaggcc atccaggaaa accaggagca gggcaaacgc aagattgcca     1200

aattcgagga gaagcacttg tcgagtttaa gtgccattcg agaggagttg gaactgccca     1260

acattgagaa gatgatccta gaatgcagtg ctgacatcag tgagttgttc gatgcgctca     1320

tgacgctgga gatgcagctg gtggagcagc tggaggagac tataaacatg tttgaaagga     1380

acattgttga catggtagga ctgtttatcg aaaatgtcca aagcctgatg gctcagtgcc     1440

gggacctgga gaatcaccac cacgagaagc tcctggagat ctctatcagc accctggaga     1500

agattgtcga gggcgacctg gacgaggacc tgcctaacga cctgcgcgcg ctttttgtcg     1560

ataaagatac gattgttaat gctgtcgggg catcgcacga catccacctc ctgaagattg     1620

acaatcgaga agatgagctg gtgaccagaa tcaactcttg gtgtacacgt ttaatagaca     1680

ggattcacaa ggatgagatc atgaggaacc gcaagcgcgt gaaggagatc aatcagtaca     1740

tcgaccacat gcagagcgaa ctggacaacc tggaatgtgg cgacatccta gactagatga     1800

atgtcagcca caggagcttc ttcaaaacat agcaccagcc ccagccagga gaaggaagtg     1860

cacacgcctc acccgcacct ctagagagtt gctgggcatc tctcaaccgc gatccccaac     1920

accattcttc ccccacccct ggaaaaactt ccaaaagtag agaaaataaa ggactcattt     1980

cacatttccc ctactcataa aaaaaaaaaa aaaa                                 2014


<210> 2527
<211> 2008
<212> DNA
<213> Homo sapiens

<400> 2527
ccttagcaac caagtcgcgg cgcttggttc cccagcaacc gggagacgcg tctgctgcgt       60

ggaaccgccg agttcccagc gcttgagaag gaaaattctg gatctgttat ctgtgaggag      120

gccactccgt tgacagttgt gtaaaactct gctgctttcc ccagctccaa cctctctggt      180

cttcaacaac actatcatca gggaaaacgt gggggaagat gaaccagccg tgcaactcga      240

tggagccgag ggtgatggac gatgacatgc tcaagctggc cgtcggggac cagggccccc      300

aggaggaggc cgggcagctg gccaagcagg agggcatcct cttcaaggat gtcctgtccc      360

tgcagctgga ctttcggaac atcctccgca tagacaacct ctggcagttt gagaacttga      420

ggaagctgca gctggacaat aacatcattg agaagatcga gggcctggag aacctcgcac      480

acctggtctg gctggatctg tctttcaaca acattgagac catcgagggg ctggacacac      540

tggtgaacct ggaggacctg agcttgttca acaaccggat ctccaagatc gactccctgg      600

acgccctcgt caagctgcag gtgttgtcgc tgggcaacaa ccggattgac aacatgatga      660

acatcatcta cctccggcgg ttcaagtgcc tgcggacgct cagcctctct aggaacccta      720

tctctgaggc agaggattac aagatgttca tctgtgccta ccttcctgac ctcatgtacc      780

tggactaccg gcgcattgat gaccacacaa aaaagcttgc ggaggctaag caccagtaca      840

gcatcgacga gctgaagcac caggagaacc tgatgcaggc ccagctggag gacgagcagg      900

cgcagcggga ggagctagag aagcacaaga ctgcgtttgt ggaacacctg aatggctcct      960

tcctgtttga cagcatgtac gctgaggact cagagggcaa caatctgtcc tacctgcctg     1020

gtgtcggtga gctccttgag acctacaagg acaagtttgt catcatctgc gtgaatattt     1080

ttgagtatgg cctgaaacag caggagaagc ggaaaacaga gcttgacacc ttcagtgaat     1140

gtgtccgtga ggccatccag gaaaaccagg agcagggcaa acgcaagatt gccaaattcg     1200

aggagaagca cttgtcgagt ttaagtgcca ttcgagagga gttggaactg cccaacattg     1260

agaagatgat cctagaatgc agtgctgaca tcagtgagtt gttcgatgcg ctcatgacgc     1320

tggagatgca gctggtggag cagctggagg agactataaa catgtttgaa aggaacattg     1380

ttgacatggt aggactgttt atcgaaaatg tccaaagcct gatggctcag tgccgggacc     1440

tggagaatca ccaccacgag aagctcctgg agatctctat cagcaccctg gagaagattg     1500

tcgagggcga cctggacgag gacctgccta acgacctgcg cgcgcttttt gtcgataaag     1560

atacgattgt taatgctgtc ggggcatcgc acgacatcca cctcctgaag attgacaatc     1620

gagaagatga gctggtgacc agaatcaact cttggtgtac acgtttaata gacaggattc     1680

acaaggatga gatcatgagg aaccgcaagc gcgtgaagga gatcaatcag tacatcgacc     1740

acatgcagag cgaactggac aacctggaat gtggcgacat cctagactag atgaatgtca     1800

gccacaggag cttcttcaaa acatagcacc agccccagcc aggagaagga agtgcacacg     1860

cctcacccgc acctctagag agttgctggg catctctcaa ccgcgatccc caacaccatt     1920

cttcccccac ccctggaaaa acttccaaaa gtagagaaaa taaaggactc atttcacatt     1980

tcccctactc ataaaaaaaa aaaaaaaa                                        2008


<210> 2528
<211> 2853
<212> DNA
<213> Homo sapiens

<400> 2528
cctccctcca gtctccggat ctccctcggt ccctctctcc tcctcttcct ctctctggac       60

gcccggctcc tccgcacccc ctcccccggg ggtcccgcgg ccttgctccc taccctcacc      120

tcaagacgac catggccacc atcccagact ggaagctaca gctgctagcc cggcgccggc      180

aggaggaggc gtccgttcga ggccgagaga aagcagaacg ggagcgcctg tcccagatgc      240

cagcctggaa acgagggctc ctggagcgcc gccgggccaa gcttgggctg tcccctgggg      300

agcctagccc tgtgctaggg actgtagagg ctggacctcc agacccggat gagtctgcgg      360

tccttctgga ggccatcggg ccagtgcacc agaaccgatt catccggcag gagcggcagc      420

agcagcagca gcaacaacaa cggagtgaag agctgctagc agagagaaag cctgggcctc      480

tggaggcccg ggagcggaga cccagccctg gggagatgcg ggatcagagc cccaagggaa      540

gagagtcaag agaagagaga ctaagtccga gggagaccag agagaggagg ctggggatag      600

ggggagccca agagttgagc ctgaggcctc tggaggctcg ggactggagg caaagcccag      660

gagaggtggg agacaggagc tcccgactgt cagaggcatg gaaatggagg ctgagtcctg      720

gagaaactcc agagcggagt ctgagactag cagagtctcg agagcaaagc cccaggagaa      780

aagaggtgga aagtagactg agcccagggg aatctgccta ccagaagttg ggcctgacag      840

aggcccataa atggagacct gactccagag agtctcagga acagagtttg gtacaactgg      900

aggcaacaga gtggaggctg aggtcaggag aagaaagaca agactactcg gaagaatgtg      960

ggagaaaaga agagtggcca gttccagggg tagctccaaa agagactgca gagctgtccg     1020

agaccctgac aagggaggcc caaggcaaca gttccgcagg agtggaggca gcagagcaga     1080

ggcctgtgga agatggcgag aggggcatga agccaacaga agggtggaaa tggaccctga     1140

actccgggaa ggctcgagaa tggacaccca gggacataga ggctcaaact cagaaaccag     1200

aacctccaga gtcagcagag aagcttctgg aatctcccgg tgtggaggct ggagaagggg     1260

aggctgagaa ggaggaggcg ggggctcagg gcaggcctct gagagccctg cagaactgct     1320

gctctgtgcc ctcccccctc ccaccagagg acgctgggac tggaggcctg agacagcagg     1380

aagaggaagc agtggagctc cagcccccac caccagcccc tctgtctccc ccacccccag     1440

ccccaactgc cccccaacct cctggggatc ccctcatgag ccgcctgttc tatggggtga     1500

aggcagggcc aggggtgggg gccccccgcc gcagtggaca caccttcacc gtcaaccccc     1560

ggcggtctgt gccccctgcg accccagcca ccccaacctc tccagccaca gttgatgctg     1620

cagtcccggg ggctgggaag aagcggtacc caactgccga ggagatcttg gttctggggg     1680

gctacctccg tctcagccgc agctgccttg ccaaggggtc ccccgaaaga caccacaaac     1740

agcttaagat ctccttcagc gagacagccc tggagaccac gtaccaatac ccctccgaga     1800

gttcggtact ggaggagctg ggcccggagc ctgaggtccc cagtgccccc aaccctccag     1860

cagcccaacc cgacgacgaa gaggatgagg aagagctgct gctgctgcag ccagagctcc     1920

agggcgggct gcgcaccaag gccctgattg tggatgagtc ctgccggcgg tgaccatctt     1980

ccaacatagg gatatacctc cctccttctt ataactgaag atcctggagc ccggaagatt     2040

cagggcagac agaccctgat aatgagcctg gcagggaagg gcaaccaaca tcttgtaact     2100

tgctttcccc accctgtttc tgggggcaga gccaattgcc caatttctac cctaatccaa     2160

agtccctggt gtgggtgggg ttaaacgtgc tggtgcatcc taggtcatcc aagagtgagc     2220

gccaagtcct gagaaggggc acagaactcc ctggagggtg gagatggagc acctgccccc     2280

catggcaggg tacactctcc ccacagcctt cctccccacc atcccgtggg gactctcggg     2340

atttaagcac tcgtctctct gggaggccca gaccccactc catttatagg cacatctcct     2400

tcatttccta ggtcactgcc cctttgttta cagctcctgc ctcctccctt gaccacagcc     2460

tggtttacaa attccatcag ctcccagccc cacctgccaa agtcccaggt ttacaagcca     2520

cgcttacttg ctgtgtctgc gtggaattct ctcctctgtc ccctccagtc tcctcattgg     2580

agtgacctga aggtgtggct tcctccactt tttctcagta ttactttgcc ttagttttcc     2640

ccaagaggga aggctggaac tcttaactct gtaccccttg atagttattt aattctgttt     2700

ctcctagtgg ttcacaattg aactgaattg agatggtgtc gggtggctaa ggagacacct     2760

cacctctcct tccccattgt gccgccttta tcaattgcct gttttgtttt gtttgttttt     2820

taactttcca taataaaatg gagttctctt caa                                  2853


<210> 2529
<211> 740
<212> DNA
<213> Homo sapiens

<400> 2529
gggtttatta ctactgaagg aagaacgtga gtaggttagg atttcggttg agaggcttgg       60

ggtcttgcgt ttcgcccacc atctcctggg gacagggtgg agtcgatatc cgggacgggg      120

gggaggttgc ggtgcccctc agggctacct ctcaagagtg ctatcatttc cgcaggccag      180

atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac      240

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      300

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      360

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      420

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      480

ggccacagta gggaagaggc tggactatat cacagctgaa attaagcgat acgaatccca      540

gcttcgggat cttgagcggc agtcagagca acagagggag acccttgctc agctgcagca      600

ggagttccag cgggcccagg cagcaaaggc aggggctcct ggcaaggcct gaccccatgg      660

tggggggagg ggaggggagg ggagggaatg aggcagctct aggatctata ctgtagctaa      720

taaaatgtaa aaacacctgg                                                  740


<210> 2530
<211> 884
<212> DNA
<213> Homo sapiens

<400> 2530
atcttgagtg agggcacgct ctccttagag gggcggaaca gtttttggca ccttatcgcg       60

agcggcagct tatgcaagag tgacttaaaa aagaaaggca ggtccggggc caggggctaa      120

gtagcggtgc ggtttctttt tctggattag tttccccatc ttgcctaaaa atgtcctagt      180

ctagtctttt tagcagaact ccactcccta aacatgtcag aactacactt cccatcaagg      240

gtcagaaaga aacttccggc acagtctttt cccagcattc cttgtttact tccgggttta      300

ttactactga aggaagaacg ccagatcaga aaagggagct caggtacctt ccagagagtg      360

agacccagcg cccttgtctc gcacccagta ggctttcatc cccgccatgg cggagctgat      420

ccagaagaag ctacagggag aagtggagaa atatcaacag ctacagaagg acttaagtaa      480

atccatgtcg gggaggcaga aacttgaagc acaactaaca gaaaataata tcgtgaaaga      540

ggaactggcc ctgctggatg ggtccaacgt ggtctttaaa cttctgggtc cggtgctagt      600

caaacaggag ctgggggagg ctcgggccac agtagggaag aggctggact atatcacagc      660

tgaaattaag cgatacgaat cccagcttcg ggatcttgag cggcagtcag agcaacagag      720

ggagaccctt gctcagctgc agcaggagtt ccagcgggcc caggcagcaa aggcaggggc      780

tcctggcaag gcctgacccc atggtggggg gaggggaggg gaggggaggg aatgaggcag      840

ctctaggatc tatactgtag ctaataaaat gtaaaaacac ctgg                       884


<210> 2531
<211> 7396
<212> DNA
<213> Homo sapiens

<400> 2531
attgctggag cgcaggcggc ggagaggatg actgccgctg ccattctctc ttgagctagc       60

gagccgccgc caccctccac cctcccccgg cagggcggag aggagcggcc ggagtcagcg      120

atggtgcccg gcgaggagaa ccaactggtc ccgaaagagg atgtgttttg gagatgcaga      180

caaaatatct ttgatgaaat gaagaagaaa tttttacaga tagaaaatgc tgctgaagaa      240

cctagagtct tatgtattat acaagatact actaattcaa agacagtgaa tgaacggatc      300

actttaaatt taccagcatc tactccagtc agaaagctct ttgaagatgt ggccaacaaa      360

gtaggctaca taaatggaac ctttgacttg gtgtggggaa atggaatcaa tactgctgat      420

atggcaccac tggatcatac cagtgacaag tcacttctcg acgctaattt tgagccagga      480

aagaagaact ttctgcattt gacagataaa gatggtgaac aacctcaaat actgctggag      540

gattccagtg ctggggaaga cagtgttcat gacaggttta taggtccgct tccaagagaa      600

ggttctgggg gttctaccag tgattatgtc agccaaagct actcctactc atctattttg      660

aataaatcag aaactggata tgtgggacta gtaaaccaag caatgacttg ctatttgaat      720

agccttttgc aaacactttt tatgactcct gaatttagga atgcattata taagtgggaa      780

tttgaagaat ctgaagaaga tccagtgaca agtattccat accaacttca aaggcttttt      840

gttttgttac aaaccagcaa aaagagagca attgaaacca cagatgttac aaggagcttt      900

ggatgggata gtagtgaggc ttggcagcag catgatgtac aagaactatg cagagtcatg      960

tttgatgctt tggaacagaa atggaagcaa acagaacagg ctgatcttat aaatgagcta     1020

tatcaaggca agctgaagga ctacgtgaga tgtctggaat gtggttatga gggctggcga     1080

atcgacacat atcttgatat tccattggtc atccgacctt atgggtccag ccaagcattt     1140

gctagtgtgg aagaagcatt gcatgcattt attcagccag agattctgga tggcccaaat     1200

cagtattttt gtgaacgttg taagaagaag tgtgatgcac ggaagggcct tcggtttttg     1260

cattttcctt atctgctgac cttacagctg aaaagattcg attttgatta tacaaccatg     1320

cataggatta aactgaatga tcgaatgaca tttcccgagg aactagatat gagtactttt     1380

attgatgttg aagatgagaa atctcctcag actgaaagtt gcactgacag tggagcagaa     1440

aatgaaggta gttgtcacag tgatcagatg agcaacgatt tctccaatga tgatggtgtt     1500

gatgaaggaa tctgtcttga aaccaatagt ggaactgaaa agatctcaaa atctggactt     1560

gaaaagaatt ccttgatcta tgaacttttc tctgttatgg ttcattctgg gagcgctgct     1620

ggtggtcatt attatgcatg tataaagtca ttcagtgatg agcagtggta cagcttcaat     1680

gatcaacatg tcagcaggat aacacaagag gacattaaga aaacacatgg tggatcttca     1740

ggaagcagag gatattattc tagtgctttc gcaagttcca caaatgcata tatgctgatc     1800

tatagactga aggatccagc cagaaatgca aaatttctag aagtggatga atacccagaa     1860

catattaaaa acttggtgca gaaagagaga gagttggaag aacaagaaaa gagacaacga     1920

gaaattgagc gcaatacatg caagataaaa ttattctgtt tgcatcctac aaaacaagta     1980

atgatggaaa ataaattgga ggttcataag gataagacat taaaggaagc agtagaaatg     2040

gcttataaga tgatggattt agaagaggta atacccctgg attgctgtcg ccttgttaaa     2100

tatgatgagt ttcatgatta tctagaacgg tcatatgaag gagaagaaga tacaccaatg     2160

gggcttctac taggtggcgt caagtcaaca tatatgtttg atctgctgtt ggagacgaga     2220

aagcctgatc aggttttcca atcttataaa cctggagaag tgatggtgaa agttcatgtt     2280

gttgatctaa aggcagaatc tgtagctgct cctataactg ttcgtgctta cttaaatcag     2340

acagttacag aattcaaaca actgatttca aaggccatcc atttacctgc tgaaacaatg     2400

agaatagtgc tggaacgctg ctacaatgat ttgcgtcttc tcagtgtctc cagtaaaacc     2460

ctgaaagctg aaggattttt tagaagtaac aaggtgtttg ttgaaagctc cgagactttg     2520

gattaccaga tggcctttgc agactctcat ttatggaaac tcctggatcg gcatgcaaat     2580

acaatcagat tatttgtttt gctacctgaa caatccccag tatcttattc caaaaggaca     2640

gcataccaga aagctggagg cgattctggt aatgtggatg atgactgtga aagagtcaaa     2700

ggacctgtag gaagcctaaa gtctgtggaa gctattctag aagaaagcac tgaaaaactc     2760

aaaagcttgt cactgcagca acagcaggat ggagataatg gggacagcag caaaagtact     2820

gagacaagtg actttgaaaa catcgaatca cctctcaatg agagggactc ttcagcatca     2880

gtggataata gagaacttga acagcatatt cagacttctg atccagaaaa ttttcagtct     2940

gaagaacgat cagactcaga tgtgaataat gacaggagta caagttcagt ggacagtgat     3000

attcttagct ccagtcatag cagtgatact ttgtgcaatg cagacaatgc tcagatccct     3060

ttggctaatg gacttgactc tcacagtatc acaagtagta gaagaacgaa agcaaatgaa     3120

gggaaaaaag aaacatggga tacagcagaa gaagactctg gaactgatag tgaatatgat     3180

gagagtggca agagtagggg agaaatgcag tacatgtatt tcaaagctga accttatgct     3240

gcagatgaag gttctgggga aggacataaa tggttgatgg tgcatgttga taaaagaatt     3300

actctggcag ctttcaaaca acatttagag ccctttgttg gagttttgtc ctctcacttc     3360

aaggtctttc gagtgtatgc cagcaatcaa gagtttgaga gcgtccggct gaatgagaca     3420

ctttcatcat tttctgatga caataagatt acaattagac tggggagagc acttaaaaaa     3480

ggagaataca gagttaaagt ataccagctt ttggtcaatg aacaagagcc atgcaagttt     3540

ctgctagatg ctgtgtttgc taaaggaatg actgtacggc aatcaaaaga ggaattaatt     3600

cctcagctca gggagcaatg tggtttagag ctcagtattg acaggtttcg tctaaggaaa     3660

aaaacatgga agaatcctgg cactgtcttt ttggattatc atatttatga agaagatatt     3720

aatatttcca gcaactggga ggttttcctt gaagttcttg atggggtaga gaagatgaag     3780

tccatgtcac agcttgcagt tttgtcaaga cggtggaagc cttcagagat gaagttggat     3840

cccttccagg aggttgtatt ggaaagcagt agtgtggacg aattgcgaga gaagcttagt     3900

gaaatcagtg ggattccttt ggatgatatt gaatttgcta agggtagagg aacatttccc     3960

tgtgatattt ctgtccttga tattcatcag gatttagact ggaatcctaa agtttctacc     4020

ctgaatgtct ggcctcttta tatctgtgat gatggtgcgg tcatatttta tagggataaa     4080

acagaagaat taatggaatt gacagatgag caaagaaatg aactgatgaa aaaagaaagc     4140

agtcgactcc agaagactgg acatcgtgta acatactcac ctcgtaaaga gaaagcacta     4200

aaaatatatc tggatggagc accaaataaa gatctgactc aagactgact ctgatagtgt     4260

agcattttcc ctgggggagt tttggtttta attagatggt tcactaccac tgggtagtgc     4320

cattttggcc ggacatggtt ggggtaaccc agtgacacca gcactgattg gactgcccta     4380

caccaatcag aagctcagtg cccaatgggc cactgttttg actcggaatc atgttgtgca     4440

ctatagtcaa atgtactgta aagtgaaaag ggatgtgcaa aaaaataaaa aaaaacaaca     4500

aaaaaagcta accttctatt agaaaagggg acaggggaat gagtaaactt cttttattgc     4560

ggacaaatgt gcacatagcc gctagtaaaa ctagcctcaa acaggatgct catagcttaa     4620

taataaaagc tgtgcaaagg ccatgaatga atgaattttc tgtttatttc actgatgcac     4680

acattacctc attgacaatt cagaagtaaa tccaacgtgt gttgactctt ggaaagcagc     4740

aaaaacagga gctgaagaaa agaaattctt ggaaccagcc gtaacccagt aaggaattgt     4800

gaagttgtgt ttttattttg tttcattttt tgcagagtat taagaacatt attctggaac     4860

atcagaacgt ttcccttaga ccgatcccag caggtggcag ctcagattgc tgcagtgttg     4920

taattataac tgattgtact taagttatgg atgtagagaa tatgtttcat tcatttattc     4980

agcatgtaaa taaaattgat cctgttgagt tatcataatt gcagttcaac tatctgccat     5040

gattattctt ttcacgtatc attcattctg tacatttgtg tacattgaga agtatagcaa     5100

tctatgtaaa tgtaatcctc agtgaggttc ctcagtgcta ggtcccatag gattgtcgtt     5160

gcccttgtta atgaggtttc tctgttcagc ggcttcaatt tttttctctt tgtacatcta     5220

gttttgaaga tttacttcaa gtttgaatct tctagaatgc ttgtaagtcc agttttaatt     5280

tttagagtca atttgtagtt acatgtagtt taacttttgg gaaacgtctt aacattgttc     5340

tgaataaact tgctaatgag gtcaggtcat ggtacagact gatgcagtca acatgatttc     5400

attgcagagt ttattagtat cagcaagttt ttgctttgct aaataaaagt actcaatgaa     5460

cacaattcta cataaatttt gacataccat ctaatttata aaaatcaata aaaaaggttt     5520

tggtaaaact ttttcatgcc agatgctgtt tacaacaatg aacatgccaa taaaacattt     5580

gttcattctg ttgtgttatt ttagtcatta aacttctgtg gatgaagaat ctgggttaag     5640

aatagatttg tcatctttaa atatgacatt ttgtaatgtg tattggatat ctcatttcta     5700

tgataaaggt atatttacag taaagttctc ataagagaaa tgaaaagctg tgttaatatc     5760

taactttggg gaaccctgtc agtatttcag atccgatttt tacccttttt ttcttataag     5820

aaagataaaa ttagaaaata ctgttagcaa atgtggctct gccatttgaa tataatcacc     5880

gagaattcca tgtcttaaaa gtctcctgga atccacaatg aaaaaaaaaa tcttttctaa     5940

ggtatttttc tggctaattt ttatttgaag aaagctatag catttagcga aatttgactg     6000

aagtaatgtt ctgagtttgc attagtggga ttggtgatgt tctcagaaga aaattggaaa     6060

cacttgtgat gaattgtctt tcagatcact tagattttct gatgtaagag gacagctgtt     6120

tggttctgat acaggcctgc ttacttggga tgtagggtta gtaaatgggg tttctgcttt     6180

aaaggactga cttgctatca cacaaaagag gcagacttgt aaacacaatg ggctttggag     6240

tttggtctga ttgggtttgg tttagtattc ctatgagcgt aaatggtaaa attcttctga     6300

tacccactct ttagactgtg ccttctgctc tgttctttgt tttatgttta actgctgttt     6360

ctaattgcag gtgtattaca gatacaaata agagtaaaga aaatatattt cattatagaa     6420

aagaaaaaat taaaagcttc ttgcttttca gtgcctgata gagtgaaaac acaaagttgc     6480

actttaataa tttcaataaa agctaatctg tgtcagcctc cctctgcttc agagagtcag     6540

gtgagcatcc ataacctaac aggcagagcc ctagcgatgt ggatcaagtt tcctgagccc     6600

gggggcggtg gagcctcatg atctcttatc ttttgaggct gaggcaggtc acatgcaaca     6660

aattgtgacc ctgctcccca caagtcatgc aaaggttttg aagagctttt accgtggggc     6720

agatgaactt gtgtcaacca tgcacaccct gtgagaacca agtacctgtg tttctaaggc     6780

gggcactcaa ggtgaggggt gcattctggc caaagaaaca aaagctgtgg tttcaggacc     6840

atgccgtgtg tagctgatct gtacgggacg tgtatgtaag gaagagcaat catgatagat     6900

aagaacagtg tgtgaagcag ccttcacact agagtgtttg gtcatctctt ataatgtaag     6960

ggaaggtact ttaaaattct gggaagatgc gatgaactca tgtcccagtc agaaaataat     7020

ccaatgaaat aagcattggt tgccaggcca cagttaggaa ttgtattgtg atacatctag     7080

aggccaagag agcaggagag agctaccaac ttacactgtg gtttaagcta aatgaccgca     7140

cagcatcata gcattgcagt gttgttacta aatctggaag tgacctgtga atgtatggaa     7200

tacaataaag tcttttattc tggttcattt gctagtactt cctttttgat tggatactgt     7260

agttcttcct ctggatttta ttttgttcag cgtcaaggcc ctaattttgc aaatgtagtc     7320

taaaccacat tacgtggact agaggatact ctgaattagc aagttttttg tttgctgaat     7380

aaaactattc catctt                                                     7396


<210> 2532
<211> 661
<212> DNA
<213> Homo sapiens

<400> 2532
acggcttacc cgggctccga cagcggctgc aggtctccaa gttgcggccg ctggagcccg       60

agccatgcgg accgcggacc gggaggcgcg cccggggctt ccgtccctgc tgctgctgct      120

gctggccggg gccgggctgt cagccgcctc gcccccagca gcgccgcgct tcaacgtgag      180

cctggactcg gtccccgagc tgcgctggct gcccgtgctg cggcactacg acttggactt      240

ggtgcgcgcc gcgatggcgc aagtcatcgg ggacagagtc cccaagtggg tgcacgtgtt      300

aatcggaaaa gtggtcctgg agctggagcg cttcctgccc cagcccttca ccggcgagat      360

ccgcggcatg tgtgacttca tgaacctcag cctggcggac tgccttctgg tcaacctggc      420

ctacgagtcc tccgtgttct gcaccagtat tgtggctcaa gactccagag gccacattta      480

ccatggtcgg aatttggatt atccttttgg gaatgtctta cgcaagctga cagtggatgt      540

gcaattctta aagaatgggc agattgcatt cacaggaact acttttattg gctatgtagg      600

attatggact ggccagagcc cacacaagtt tacagtttct ggtgatgaac gagaccctca      660

c                                                                      661


<210> 2533
<211> 1731
<212> DNA
<213> Homo sapiens

<400> 2533
acggcttacc cgggctccga cagcggctgc aggtctccaa gttgcggccg ctggagcccg       60

agccatgcgg accgcggacc gggaggcgcg cccggggctt ccgtccctgc tgctgctgct      120

gctggccggg gccgggctgt cagccgcctc gcccccagca gcgccgcgct tcaacgtgag      180

cctggactcg gtccccgagc tgcgctggct gcccgtgctg cggcactacg acttggactt      240

ggtgcgcgcc gcgatggcgc aagtcatcgg ggacagagtc cccaagtggg tgcacgtgtt      300

aatcggaaaa gtggtcctgg agctggagcg cttcctgccc cagcccttca ccggcgagat      360

ccgcggcatg tgtgacttca tgaacctcag cctggcggac tgccttctgg tcaacctggc      420

ctacgagtcc tccgtgttct gcaccagtat tgtggctcaa gactccagag gccacattta      480

ccatggtcgg aatttggatt atccttttgg gaatgtctta cgcaagctga cagtggatgt      540

gcaattctta aagaatgggc agattgcatt cacaggaact acttttattg gctatgtagg      600

attatggact ggccagagcc cacacaagtt tacagtttct ggtgatgaac gagataaagg      660

ctggtggtgg gagaatgcta tcgctgccct gtttcggaga cacattcccg tcagctggct      720

gatccgcgct accctgagtg agtcggaaaa cttcgaagca gctgttggca agttggccaa      780

gactcccctt attgctgatg tttattacat tgttggtggc acgtcccccc gggagggggt      840

ggtcatcacg aggaacagag atggcccagc agacatttgg cctctagatc ctttgaatgg      900

agcgtggttc cgagttgaga caaattacga ccactggaag ccagcaccca aggaagatga      960

ccggagaaca tctgccatca aggcccttaa tgctacagga caagcaaacc tcagcctgga     1020

ggcacttttc cagtgagcaa gaagaaccca tcaggtgatt gtcaggcctc tgagcccaag     1080

ctaagccatc atatgccctg tgacctgcac gtatacatcc agatggcctg aagcaactga     1140

agatccacaa aagaagagaa aatagccagt tcctgcctta actgatgaca tttcaccatt     1200

gtgatttgtt cctgccccac cctaactgat caattgactt tgtgacaaga caccctcccc     1260

acccttgcaa taatgtactt tgtgatattc ccccgccctt gtgaatgtac tttgtacgat     1320

acaccctccc cacccttgag aaggtacttt gtaatatcct ctccgccctt gagaatgtac     1380

tttgtaagat ccacttcctg cctgcaaaaa attgctccga actccaccgt ctatcccaaa     1440

cctataagaa ctaatgataa tcctaccacc ctttgctgac tccttttttg gactcagccc     1500

acgtgcaccc aggtgattaa aaagctttat tgctcacatg aagcctattt ggtggtctct     1560

tcacacagat gtgtgtgaca gtgataacag tgtcacgtgg tttaactaca atgtgtccag     1620

atattgaatt ttgtttaagc ctgcttggga tttgttgtgc tccccaaatt tcaagtttgt     1680

gtcttttgtt caattttgga aaatagtcag ctatctcaga attgctcacc t              1731


<210> 2534
<211> 7011
<212> DNA
<213> Homo sapiens

<400> 2534
atggcggcgg cggcggggaa tcgcgcctcg tcgtcgggat tcccgggcgc cagggctacg       60

agccctgagg caggcggcgg cggaggagcc ctcaaggcga gcagcgcgcc cgcggctgcc      120

gcgggactgc tgcgggaggc gggcagcggg ggccgcgagc gggcggactg gcggcggcgg      180

cagctgcgca aagtgcggag tgtggagctg gaccagctgc ctgagcagcc gctcttcctt      240

gccgcctcac cgccggcctc ctcgacttcc ccgtcgccgg agcccgcgga cgcagcgggg      300

agtgggaccg gcttccagcc tgtggcggtg ccgccgcccc acggagccgc gagccgcggc      360

ggcgcccacc ttaccgagtc ggtggcggcg ccggacagcg gcgcctcgag tcccgcagcg      420

gccgagcccg gggagaagcg ggcgcccgcc gccgagccgt ctcctgcagc ggcccccgcc      480

ggtcgtgaga tggagaataa agaaactctc aaagggttgc acaagatgga tgatcgtcca      540

gaggaacgaa tgatcaggga gaaactgaag gcaacctgta tgccagcctg gaagcacgaa      600

tggttggaaa ggagaaatag gcgagggcct gtggtggtaa aaccaatccc agttaaagga      660

gatggatctg aaatgaatca cttagcagct gagtctccag gagaggtcca ggcaagtgcg      720

gcttcaccag cttccaaagg ccgacgcagt ccttctcctg gcaactcccc atcaggtcgc      780

acagtgaaat cagaatctcc aggagtaagg agaaaaagag tttccccagt gccttttcag      840

agtggcagaa tcacaccacc ccgaagagcc ccttcaccag atggcttctc accatatagc      900

cctgaggaaa caaaccgccg tgttaacaaa gtgatgcggg ccagactgta cttactgcag      960

cagatagggc ctaactcttt cctgattgga ggagacagcc cagacaataa ataccgggtg     1020

tttattgggc ctcagaactg cagctgtgca cgtggaacat tctgtattca tctgctattt     1080

gtgatgctcc gggtgtttca actagaacct tcagacccaa tgttatggag aaaaacttta     1140

aagaattttg aggttgagag tttgttccag aaatatcaca gtaggcgtag ctcaaggatc     1200

aaagctccat ctcgtaacac catccagaag tttgtttcac gcatgtcaaa ttctcataca     1260

ttgtcatcat ctagtacttc tacgtctagt tcagaaaaca gcataaagga tgaagaggaa     1320

cagatgtgtc ctatttgctt gttgggcatg cttgatgaag aaagtcttac agtgtgtgaa     1380

gacggctgca ggaacaagct gcaccaccac tgcatgtcaa tttgggcaga agagtgtaga     1440

agaaatagag aacctttaat atgtcccctt tgtagatcta agtggagatc tcatgatttc     1500

tacagccacg agttgtcaag tcctgtggat tccccttctt ccctcagagc tgcacagcag     1560

caaaccgtac agcagcagcc tttggctgga tcacgaagga atcaagagag caattttaac     1620

cttactcatt atggaactca gcaaatccct cctgcttaca aagatttagc tgagccatgg     1680

attcaggtgt ttggaatgga actcgttggc tgcttatttt ctagaaactg gaatgtgaga     1740

gagatggccc tcaggcgtct ttcccatgat gtcagtgggg ccctgctgtt ggcaaatggg     1800

gagagcactg gaaattctgg gggcagcagt ggaagcagcc cgagtggggg agccaccagt     1860

gggtcttccc agaccagtat ctcaggagat gtggtggagg catgctgcag cgttctgtca     1920

atggtctgtg ctgaccctgt ctacaaagtg tacgttgctg ctttaaaaac attgagagcc     1980

atgctggtat atactccttg ccacagttta gcggaaagaa tcaaacttca gagacttctc     2040

cagccagttg tagacaccat cctagtcaaa tgtgcagatg ccaatagccg cacaagtcag     2100

ctgtccatat caacactgtt ggaactgtgc aaaggccaag caggagagtt ggcagttggc     2160

agagaaatac taaaagctgg atccattggt attggtggtg ttgattatgt cttaaattgt     2220

attcttggaa accaaactga atcaaacaat tggcaagaac ttcttggccg cctttgtctt     2280

atagatagac tgttgttgga atttcctgct gaattttatc ctcatattgt cagtactgat     2340

gtttcacaag ctgagcctgt tgaaatcagg tataagaagc tgctgtccct cttaaccttt     2400

gctttgcagt ccattgataa ttcccactca atggttggca aactttccag aaggatctac     2460

ttgagttctg caagaatggt tactacagta ccccatgtgt tttcaaaact gttagaaatg     2520

ctgagtgttt ccagttccac tcacttcacc aggatgcgtc gccgtttgat ggctattgca     2580

gatgaggtgg aaattgccga agccatccag ttgggcgtag aagacacttt ggatggtcaa     2640

caggacagct tcttgcaggc atctgttccc aacaactatc tggaaaccac agagaacagt     2700

tcccctgagt gcacagtcca tttagagaaa actggaaaag gattatgtgc tacaaaattg     2760

agtgccagtt cagaggacat ttctgagaga ctggccagca tttcagtagg accttctagt     2820

tcaacaacaa caacaacaac aacaacagag caaccaaagc caatggttca aacaaaaggc     2880

agaccccaca gtcagtgttt gaactcctct cctttatctc atcattccca attaatgttt     2940

ccagccttgt caaccccttc ttcttctacc ccatctgtac cagctggcac tgcaacagat     3000

gtctctaagc atagacttca gggattcatt ccctgcagaa taccttctgc atctcctcaa     3060

acacagcgca agttttctct acaattccac agaaactgtc ctgaaaacaa agactcagat     3120

aaactttccc cagtctttac tcagtcaaga cccttgccct ccagtaacat acacaggcca     3180

aagccatcta gacctacccc aggtaataca agtaaacagg gagatccctc aaaaaatagc     3240

atgacacttg atctgaacag tagttccaaa tgtgatgaca gctttggctg tagcagcaat     3300

agtagtaatg ctgttatacc cagtgacgag acagtgttca ccccagtaga ggagaaatgc     3360

agattagatg tcaatacaga gctcaactcc agtattgagg accttcttga agcatctatg     3420

ccttcaagtg atacaacagt aacttttaag tcagaagttg ctgtcctgtc tcctgaaaag     3480

gctgaaaatg atgataccta caaagatgat gtgaatcata atcaaaagtg caaagagaag     3540

atggaagctg aagaagaaga agctttagca attgccatgg caatgtcagc gtctcaggat     3600

gccctcccca tagttcctca gctgcaggtt gaaaatggag aagatatcat cattattcaa     3660

caggatacac cagagactct accaggacat accaaagcaa aacaaccgta tagagaagac     3720

actgaatggc tgaaaggtca acagataggc cttggagcat tttcttcttg ttatcaggct     3780

caagatgtgg gaactggaac tttaatggct gttaaacagg tgacttatgt cagaaacaca     3840

tcttctgagc aagaagaagt agtagaagca ctaagagaag agataagaat gatgagccat     3900

ctgaatcatc caaacatcat taggatgttg ggagccacgt gtgagaagag caattacaat     3960

ctcttcattg aatggatggc agggggatcg gtggctcatt tgctgagtaa atatggagcc     4020

ttcaaagaat cagtagttat taactacact gaacagttac tccgtggcct ttcgtatctc     4080

catgaaaacc aaatcattca cagagatgtc aaaggtgcca atttgctaat tgacagcact     4140

ggtcagagac taagaattgc agattttgga gctgcagcca ggttggcatc aaaaggaact     4200

ggtgcaggag agtttcaggg acaattactg gggacaattg catttatggc acctgaggta     4260

ctaagaggtc aacagtatgg aaggagctgt gatgtatgga gtgttggctg tgctattata     4320

gaaatggctt gtgcaaaacc accatggaat gcagaaaaac actccaatca tcttgctttg     4380

atatttaaga ttgctagtgc aactactgct ccatcgatcc cttcacattt gtctcctggt     4440

ttacgagatg tggctcttcg ttgtttagaa cttcaacctc aggacagacc tccatcaaga     4500

gagctactga agcatccagt ctttcgtact acatggtagc caattatgca gatcaactac     4560

agtagaaaca ggatgctcaa caagagaaaa aaaacttgtg gggaaccaca ttgatattct     4620

actggccatg atgccactga acagctatga acgaggccag tggggaaccc ttacctaagt     4680

atgtgattga caaatcatga tctgtaccta agctcagtat gcaaaagccc aaactagtgc     4740

agaaactgta aactgtgcct ttcaaagaac tggccctagg tgaacaggaa aacaatgaag     4800

tttgcatgac taaattgcag aagcataatt ttattttttt ggagcacttt ttcagcaata     4860

ttagcggctg aggggctcag gatctatttt aatatttcaa ttattcttcc atttcatata     4920

gtgatcacaa gcagggggtt ctgcaattcc gttcaaattt tttgtcactg gctataaaat     4980

cagtatctgc ctcttttagg tcagagtatg ctatgagtag caatacatac atatattttt     5040

aaaagttgat acttctttat gacccacagt tgacctttat tttcttaaat accagggcag     5100

ttgtggctca ttgtgcattt tactgttggc ccattcattt cgtttttgga aattatggtt     5160

ttgtattttc atgtttattt acattcattt ttgtttattc agggaaagct gatctttttt     5220

tcaaaccaga aaaaaaaaat gaactagata tgaagtagag ttcattaaat atcttgctat     5280

tgtcagagtt tttaaaatat agacttaatt ttgttttttt aaattggaat acaataaagt     5340

actacctaca tttgagtcag tcaccactct tattgtgcag gttaagtaca agttaactaa     5400

aaataaactg tcctctctgg tgcaactcac aaccaagatc aagattacct taaaatttat     5460

ttgaattttt tagatgtttt ggttgtcaaa ctgtaggaaa cttcacaaca tttaagtctt     5520

actctgtatg taacaatcca tcattcacct tcactactgg tagtaacata gagctgccat     5580

tttcctttta ccatgcatca tctctttaca gtaggcctgg cagatcattt tttaaaaaga     5640

ttattcaact accaatcagt aatgttttta aacagtacat ttgctttgaa cttggaaaat     5700

gtgttcagaa agaaaaatgg aattgaattt catttataca ctaattcctt ggattttgca     5760

cagttaccta acggttttag tctggagtta aattcagatg catggaatcc tgaaggaaaa     5820

tggtagcttt ttaatctttt tgtgtgtgtg tgagtctttt aaatcaagta ctgattaact     5880

attaagtaca actttgagat tttagtttta actcttcaga agccagtgtg aaatagaatt     5940

ggttattctc aaagactcag gataaactaa ataagctata tatagagtac atttaaaatg     6000

tacaacacaa attggaaata aaataagtta caagataagt ttacagggat atattgctta     6060

caatttttaa aaggcagttt gttttttatg tgaatatgtt tcttagtgaa attttacatt     6120

cctttgtttt ggaagattgg cgatatttga agagttaaaa atagtacaga aatgtgaagt     6180

ttggtatctc taaatgtgtt gtacttgact ttctttttta ttttgttttt tttttttttt     6240

gactacttag aattttcaca attctaataa gattgtttcc aagtctctca tgtgcaagct     6300

ttaaaggatg cactcttgcc attttatgta ctggaagatc attggtcaga tgaatactgt     6360

gtctgacaaa aatgtaaact gtataaactg aggaacctca gctaatcagt attactttgt     6420

agatcaccat gcccaccaca tttcaaactc aaactatctg tagatttcaa aatccattgt     6480

gtttgagttt gtttgcagtt ccctcagctt gctggtaatt gtggtgtttt gttttttgtt     6540

ttgttttcaa tgcaaatgtg atgtaatatt cttattttct ttggatcaaa gctggactgg     6600

aaattgtatc gtgtaattat ttttgtgttc ttaatgttat ttggtactca agttgtaaat     6660

aacgtctact actgtttatt ccagtttcta ctacctcagg tgtcctatag atttttcttc     6720

taccaaagtt cactttcaca atgaaattat atttgctgtg tgactatgat tcctaagatt     6780

tccagggctt aagggctaac ttctattagc accttactgt gtaagcaaat gttacaaaaa     6840

aaaaaaaaaa aaatctctgg gttaagaaaa tttggcttaa atgtatcctt tgttatttta     6900

aatatattga gatattttaa ttaaaatttt taccccattg aaccgatttt atagtatttg     6960

tacctatttt ggtgtttttg tctttatagt aaataaaagt ttttgaacaa a              7011


<210> 2535
<211> 3436
<212> DNA
<213> Homo sapiens

<400> 2535
agttgctgcc atggagtcag ccgggctaga gcagctccta cgggagctgc tgctaccgga       60

caccgagcgc atccgtcggg ccacggaaca gctccagatc gttcttcggg cccccgccgc      120

tttgccggct ctctgcgacc tgctagcctc ggcggccgac ccccagacga ctgaacaccc      180

gctggcgacg gctggcggcg gagcaacggg agagcctcaa gtccctgatc ctgacggccc      240

tgcagagaga aacagagcac tgtgtgagcc tcagcctggc ccagctctca gccaccattt      300

ttcgaaagga aggcttggag gcctggccac agcttttgca gctgcttcag cacagtaccc      360

acagccccca cagcccagag agagagatgg ggcttttgct gctaagtgtg gtggtgacct      420

cccggcccga ggccttccaa ccccaccacc gggagcttct tcggcttctg aatgagactc      480

ttggtgaggt gggctctcct gggctgctct tctactccct gcgcactctg accaccatgg      540

ctccctacct cagcactgaa gatgtgcctc tcgctcggat gttggtgccc aagctgatca      600

tggccatgca gactctgatc cccatagatg aggcaaaggc ctgtgaggcc cttgaggctt      660

tggatgaact gttggagtca gaggtgccgg tcatcacccc ctacctctct gaagtcctca      720

cattctgcct ggaggtagct agaaatgtgg ccctgggcaa tgcgatacgc atacgtattc      780

tctgctgcct cactttcttg gtcaaagtca agagcaaggc cttactgaag aatcgtctcc      840

tgccaccctt gctgcacacc cttttcccca ttgtggctgc tgagccccca ccaggccagt      900

tggatcccga ggaccaggat tcagaagagg aagagttgga gattgagctg atgggggaga      960

ctcccaagca tttcgctgta caagttgtgg acatgctggc actacacctg ccccccgaga     1020

agctctgtcc ccagctgatg cccatgttgg aagaggcttt gcggagcgag agcccatacc     1080

agcgcaagga ctcctggtgc tggccgtgct gtctgacgga gctggcgacc acatcaggca     1140

gagactgctg cccccactgc tgcagattgt gtgcaagggc ctggaggacc cctcgcaagt     1200

tgtacgcaat gctgcgctgt ttgccctggg ccagttctca gaaaacctac agccccatat     1260

cagcagctat tcaagggagg taatgccact gctcctcgcc tacttgaagt cggtgcctct     1320

tggacacaca caccacctag ccaaggcctg ctatgccctg gagaattttg tggagaacct     1380

agggcccaag gtgcagccct accttccgga gcttatggaa tgcatgctgc agcttctgag     1440

gaaccccagc agtccccggg ccaaggagct ggctgtgagc gccctgggag ccattgctac     1500

ggctgcccag gcctcgctgc tgccctactt ccctgccatc atggagcacc tgcgggaatt     1560

cctgttaaca ggccgtgagg accttcagcc tgtgcagatc cagagcctgg agacactggg     1620

ggtgctggca cgagcagtgg gggagcccat gaggccgctg gctgaggaat gctgccagct     1680

gggtctgggc ctctgcgacc aggtagacga ccctgacttg cggcgctgca cgtacagcct     1740

atttgcagcc ttatcgggtc tgatgggtga gggcctggcg ccccacttgg aacagatcac     1800

cacgctcatg ctgctgtcac tgcgttccac cgagggcatt gtgcctcagt atgacgggag     1860

cagctccttc cttctgtttg acgatgagag tgatggggaa gaagaggagg agctcatgga     1920

tgaggatgtg gaagaagagg atgactcaga gatctcaggg tacagcgtgg agaatgcctt     1980

cttcgatgag aaggaagaca cctgtgctgc cgtgggggag atctctgtga acaccagtgt     2040

ggccttcctt ccatacatgg aaagtgtctt tgaagaagta tttaaactgc tggagtgccc     2100

tcacctgaat gtgcggaagg cagcccatga ggctctgggt cagttttgct gtgcactgca     2160

caaggcctgt caaagctgcc cctcggaacc caacactgct gctttgcagg ctgccctggc     2220

ccgagtcgtg ccatcctaca tgcaggcagt gaacagggag cgggaacgcc aggtggtgat     2280

ggccgtgctg gaggccctga caggggtgct ccgcagctgt gggaccctca cactgaagcc     2340

ccctgggcgc ctcgctgagc tctgtggcgt gctcaaggct gtgctgcaga ggaagacagc     2400

ctgtcaggat actgacgagg aggaggaaga ggaagatgat gatcaggctg aatacgacgc     2460

catgttgctg gagcacgctg gagaggccat ccctgccctg gcagccgcgg ctgggggaga     2520

ctcctttgcc ccattctttg ccggtttcct gccattattg gtgtgcaaga caaaacaggg     2580

ctgcacagtg gcagagaagt cctttgcagt ggggaccttg gcagagacta ttcagggcct     2640

gggtgctgcc tcagcccagt ttgtgtctcg gctgctccct gtgctgttga gcaccgccca     2700

agaggcagac cccgaggtgc gaagcaatgc catcttcggg atgggcgtgc tggcagagca     2760

tgggggccac cctgcccagg aacacttccc caagctgctg gggctccttt ttcccctcct     2820

ggcgcgggag cgacatgatc gtgtccgtga caacatctgt ggggcacttg cccgcctgtt     2880

gatggccagt cccaccagga aaccagagcc ccaggtgctg gctgccctac tgcatgccct     2940

gccactgaag gaggacttgg aggagtgggt caccattggg cgcctcttca gcttcctgta     3000

ccagagcagc cctgaccagg ttatagatgt ggctcccgag cttctgcgta tctgcagcct     3060

cattctggct gacaacaaga tcccaccaga caccaaggcc gcactgttgc tgctcctgac     3120

gttcctggcc aaacagcaca ccgacagctt tcaagcagct ctgggctcac tgcctgttga     3180

caaggctcag gagctccagg ctgtactggg cctctcctag actgcaggct gcagccagtc     3240

cagagagaat agagcctgcc caggccttaa gaccacctct cagcccagtt cagttctgcc     3300

ttaccaaaga ttctgagact catacccatt tggagccagc cccacttgct gccttacagg     3360

gctgtccctg aggctggatc tgttacaaat gagtcatgac atcatactgt aataaaagca     3420

gcttgttttc tgcttg                                                     3436


<210> 2536
<211> 2232
<212> DNA
<213> Homo sapiens

<400> 2536
atagcagggg gacagacaga gggggtgggg gtggatttgg tgttgagttg agggcagagt       60

gtgggactgg aaagggacgg ccagaggact ttgcttctag gatacctccc aaatcctctg      120

gccctggccc tcccatgcat tagcaccatc ccttctccct agacaaatgg gtgtgatacc      180

agaaggacca ctgtgggtgt cgggctcaga tgacaatttg tcgggcacga gcggtatgga      240

agtggacgac cgcgtgtcgg cgctggagca gcggctgcag ttacaggaag acgagctggc      300

ggtcctaaag gcggcgctgg cggatgctct gcgtcgcctg cgggcatgcg aagaacaggg      360

agcggcgcta cgcgcgcggg gcacccccaa gggccgggcg cctccgcgct taggcaccac      420

tgcctcggtg tgtcagctct tgaaaggcct tcccaccagg acgcccctta atggctcggg      480

acccccgcgg cgcgtgggtg gctatgccac gtccccatcc tctcccaaga aggaggcgac      540

ctccgggcgc agcagtgtcc gccgctactt gtcaccagag cgcctcgcct cggtgcgccg      600

tgaggacccc cgcagccgga ccacatcctc cagcagcaac tgtagcgcca aaaaggaagg      660

caaaaccaaa gaagttatct tcagtgtgga ggatggctcc gtgaaaatgt tcctgagggg      720

ccgccctgtg cccatgatga tcccagacga gctggcaccc acctacagcc tggacacacg      780

ctcggagctg ccttcttgcc ggctcaagct ggagtgggtc tatggctacc gtggccgaga      840

ctgccgggcc aacctttatt tgctgcccac cggggagata gtgtactttg tggcctccgt      900

agccgtgcta tacagcgtgg aggagcagag gcagcgacac tacctgggac acaacgatga      960

catcaaatgc ttggccatcc acccagatat ggtcaccatc gccacgggac aggtggcggg     1020

aaccactaag gaagggaagc cgctgccgcc ccacgtgcgc atctgggact cagtttccct     1080

ctccacctta cacgtgctgg gcttgggggt gtttgacaga gccgtgtgct gtgtgggctt     1140

ctccaaatct aatggaggca acctgctgtg tgcagtggat gaatccaatg atcacatgct     1200

ctcggtgtgg gactgggcca aggagaccaa ggtggtggat gtcaagtgct ccaatgaggc     1260

tgtattggtg gccaccttcc accccacgga ccccactgtg cttatcacct gcgggaaatc     1320

tcacatctac ttctggacct tggagggggg cagcttgagc aagcggcaag gcctctttga     1380

gaaacatgag aaaccgaagt atgtgctgtg tgtgaccttt ttggaaggtg gcgacgtggt     1440

cacgggggac tctgggggga acctctatgt ttggggcaaa ggtgggaacc gtatcacaca     1500

ggcggtgctg ggcgcccacg acggcggcgt gtttgggctc tgcgccctgc gggacgggac     1560

gctggtgtct ggagggggcc gtgatcggcg ggtggtcctc tggggttctg actacagcaa     1620

gctgcaggaa gtggaggtcc ctgaggactt tggccctgtg cgcaccgtgg cagagggcca     1680

cggagacaca ctgtacgtgg ggaccacccg caattccatc ctgcagggct ccgtgcacac     1740

aggcttctca ctgctggtcc agggccatgt ggaagagctg tggggcctgg ccacacaccc     1800

cagtcgggcc cagtttgtga cctgcgggca ggataagctg gtgcatctat ggagctcaga     1860

ttcccaccag cccctgtgga gcaggatcat cgaggtggag tctcgctctg tcacccaggc     1920

tggagggcaa tggcacgatc tcggctcact gcaacctccg cctcccgggt tcaagtgatt     1980

cttctgcctc agcctcccga gtagctggga ttacaggacc ctgcccgctc agccggcttc     2040

caccccagtg gctctgtcct ggctgtgggt acagtgactg gcagatggct gctgctggac     2100

acggagaccc atgacctggt ggctatccac acagacggca atgaacagat ctcagtggtc     2160

agcttctccc cagacggggc gtacctggcc gtgggctccc acgacaactt ggtgtacgtg     2220

tacacggtgg ac                                                         2232


<210> 2537
<211> 5068
<212> DNA
<213> Homo sapiens

<400> 2537
ggttcgggta gcggggacgc gcacgcacct tgcgcgtctt cgcccctcct gcggttgcca       60

ggcaaccggc cccggaagtt gcggcaggtg cgtccgcagc gggcgccgct agccagcgga      120

agatggcgga gggcggaggc cctgagcccg gcgagcagga gaggaggtct tccgggccgc      180

ggcctccgag cgcgcgggat ttgcagttgg ccttggcaga attgtatgaa gatgaagtga      240

agtgcaaatc ttccaagtct aatagaccta aagccacagt cttcaagagc ccacggacac      300

cacctcaacg gttttactca agtgaacatg aatacagtgg attaaatata gttcgacctt      360

caactgggaa aattgtgaat gaacttttca aagaggcaag ggaacatggg gctgtccctc      420

tgaatgaagc cacaagagct tcaggtgatg ataaatctaa gtcatttaca ggtggaggat      480

acagattggg tagttctttt tgtaagcggt ctgaatatat ctatggagaa aatcagctgc      540

aagatgttca gattttgctt aaactgtgga gcaatggttt cagtttagat gatggagaat      600

tgagacctta caatgaacca acaaatgctc aatttctgga gtctgttaag agaggagaga      660

ttcccctgga gcttcagcgc cttgttcatg gtggccaagt gaatttggat atggaggatc      720

atcaggatca agaatacata aaacctagat tgaggttcaa ggcttttagt ggagaagggc      780

aaaaacttgg aagccttaca cctgaaatag tcagtacacc ttcctctcca gaagaggagg      840

ataaatcaat acttaatgca gttgttctta ttgatgattc agtgccaaca acaaaaattc      900

aaatcaggtt agcagatggg agtcgtttga tacaaagatt caatagtaca cacaggatcc      960

tggatgtccg gaactttatt gtacagtctc gtcctgaatt tgcggctctt gactttattc     1020

ttgtgacttc atttccgaat aaagagctaa cagatgaaag cctgacactg ctagaagcag     1080

atattcttaa cactgtgtta ctccagcaac taaaataata ttgttcctgt ccatgcagta     1140

gcatgtggga atagatgatg tgccgtatta ataaggacaa tacttcagca ttaaaaacag     1200

ccaaattatt tttattattt ttacagataa attttggttt tattgttatt ctgtcttcca     1260

atctgaatat agacaaattt ggattaggaa tagaccttga gataagtatg tttgagtttt     1320

tagttgaagg actggcttat gttgatagtt tttggatttc taggcaaatg agttgttaca     1380

tgcttagtgt taatgtaaca acatttgttt gcagagaaaa atgaacaaaa cccctttttg     1440

ataaatgcat ttggtaaaat ttgcactaaa gtttcttgat gcagcattga ccaacagcca     1500

ttaagaaatc ttttgatcaa ataagttgaa aatttgtcta taatatatac tgaaacgtgt     1560

cttttgattt tgaaattgtt tgatcataca ataattattt ctcctattaa gattttacac     1620

atccttttta cttactgatt tagatatatt actagtatca gaaactacag ttttgccttg     1680

tattttacag aattatgact gttgtgaact taaacagaaa cacataaagg tcagcaattc     1740

tttttttttt tttttttgat atggagtttt gctcttgttg cccaggctgg agtgcaatgg     1800

cataatttct gctcaccgca acctccgcct cccaggttca aaagattctc ctgccttagc     1860

ctcccaagta gctgggatta caggcatgcg ccaccatgcc tggctaattt ttgtactttt     1920

gctagagaca gcgtttctct gtgttgatca ggctggtctc gaactccgaa cctcaggtga     1980

tccacccacc tcagcctccc aaagtgctgg gattacaggc atgagccacc acgcccagcc     2040

taaaggtcag cagttcttaa gaagatatgg taaacagcaa caatatttta aaatcaagta     2100

attacagttc ctcccagagc ttgcgttgat cacattcatt tattcattca acacattttt     2160

ctaggaaact cactgtatac actaaacact attctgtgtg ctcaacctag aatgtcttct     2220

ccagaacaag actagtgtag aaatacagga atgtaaattc tgtcagacgg actagatcta     2280

aagaattacc agcataaatg tttgcatttc tgctgaagcc agaagctttt ccttcttcct     2340

agacaccatt tcatccttaa ttattacttc tggttagttt tccattgcca ccataacaag     2400

ttacaaaatg tggcttaaaa tagcacaaat ttattatctt cacaattctg taggttagga     2460

gtccaggtta agagtttcgc ggtgccaaga tcaatttgtt ggcagggttg cattctgtta     2520

ggaggctcta caggagaatc atttccttgt cattccacct tctacaggac atcctcattc     2580

cttggcttgt gacctccttc ttccatctta aaaaccagtg ctgtttcatc tctatgaccc     2640

ttctgttacc acatctctct gacaccagtg tggagaggtt ctctgcagga ctcatgatta     2700

aatgaggccc accggatatc caatctaggc ttatctcctt gtcttgaaat ccatagtaac     2760

cttaattaca tctgcaaaat ctcttttacc atctaaggtt acatacaggt ttggagatta     2820

ggacattaac attttacatg gaacattatt cttgcctact acagttccca cccacccccc     2880

gctccactcc tgtgttaaag attcagattc atcacaaata aatttacatc actcataggt     2940

gctcaaaagt cacaatccat tattacagca tcaactctaa atccaaaatc ttatctgagt     3000

ctcaccaact caaaagtctc aaatctcaca ttgaagccat ctaaattaag tttgggagag     3060

gatctgtgtg tgatttctgg gacataattc caactgtgca cttgtgaacc tagaaaacaa     3120

gttatctgtt cccaagtatg atggcatgac aggcagacaa taatagttac acacgttcct     3180

gttcaaaaag cagaaacaga tggaaaaagg agccatcagc accaatcaat ttacaaaacc     3240

agcgaggcac ccttctttaa gtttcaaggc ctgggagtaa tcttcagctc actgctgttc     3300

tctgggcttg ttgactgtct cagagtcatc tttacttttt cacaaaaggt agcacacgtt     3360

tgcagctgag tatcaactta tcagtttgtt cttcttttat attctctaaa gctttctgtt     3420

aaaaatggtg gtgcttctgc tgctataacg ttgtcaagaa acttgtgggt cttttacata     3480

tgtcacaggg atgcactcat ttagatagga ggctcctcac gtatctttcc tggaaaatcc     3540

tgtctctgtt tttggctttt tctgaaatag ctgagaggat ctatgattca cacccttaat     3600

atcttcaaag agtcttgtgt gtgacctgat attcagacct tttgatgttt ctgaagtatt     3660

agcaaaaggt tatacagcca tatcttcatc actttctcta gagtaaaggc tgtcctgacg     3720

gtgaatctta gttttagtgg cttttgccat ttgaataggc cgcgaatttc ccaaatcatc     3780

aagtcctggt ttctttatat ttaacaggtc ttccctcaat ctacctcttt ccacatttta     3840

ctataatcag caagaagaca gcaggctgta ccttccacag cttgcttgga aatatcctca     3900

gctaaatatt gaagtcatca cttaaaagtt ctgctttaca cataacggca ggacacaact     3960

cagcttagct tttcgccact atgtaacaag gactcctttc ctccacttct ccagtaacat     4020

attcctcatt ttttaccaac agtctattca tgatgattta gatattctat ggcaatcgag     4080

gtattctcta ttatgctcct ttcttcaagg ccgccctagc attaacattc catatttcta     4140

ctaacagtct gtttaaggca gtttagcttc ttttctggca tgctcctcag aattcttcca     4200

gcctccacct actgcccaat tccagagcca cttttctact tttaggtatt tgttacagca     4260

gcacctcaag tacctagaaa actcttttat gcctgcttct ctgccagatg acttgaatat     4320

ggtactagat ttggaattca cctttctcca gggtcactgt ttatttcaaa gaggtgaatt     4380

tacctgtgct agggttttca cactgggagt gctaccagaa ctaccacagg atgaaagtgg     4440

tgagcccacc actgcagaga agttttctca gtgccgtaat atagaggaat tctcaaaata     4500

agccctactc cttttcactt actgaaaaca acttggataa tgtgtaacag ccagccccat     4560

ttcaaaaaga ttaccagggg taaaacaact ttttcatggg tcaaaatcat cttccgaaga     4620

aaatgatttc ttaaaagaat tgaacattgt aaatcaaagg gcattgtcct gttttggatt     4680

aacaaaacag gaaaaataac caatccttgt aaaattattt gaaattttct tgtttttatc     4740

agttgagtgc ctatagatgc acatacaaaa acaactgcca tttttgtata taatagtctt     4800

ccaagataga gatttacatt aggagagaat taaacatcca ggagggatga acagtatttc     4860

atgtgtgcta tgtagtgttt tgcttcattg agagtcattt tcatgaatta tttttactac     4920

tgcagtcatc ttaaatttat aatcatctca aaaaagatgt cacaatgaac agacaaccat     4980

ctgtgaggtc agtcattttg catgatgtat gtaatcaaaa agtttgaaat gtctgcttac     5040

taataaagaa tgttttcact gaaactta                                        5068


<210> 2538
<211> 4940
<212> DNA
<213> Homo sapiens

<400> 2538
gccgcagccg gcggaggagg cagtagcggg ggactcgatg gaccgcggct ggcaattcca       60

ggaatggatg gaggtgcttt aactgataca agtctcacag attcctattt tagcaccagc      120

tttattggag tcaatggatt tggaagccct gtagaaacaa aatatcccct gatgcagaga      180

atgactaata gtagcagctc cccaagcctt ctaaatgaca gtgccaagcc atattcagcc      240

catgatcctc taacatcacc tgcttcatcc ttgtttaatg actttggtgc cctcaacatc      300

tctcagagac gaaagacacc aaatcctact gcaagcgagt ttattcctaa aggaggatca      360

acctccaggc tgagtaacgt gtcccagtca aatatgtctg ccttctctca agttttctct      420

cacccatcca tgggaagccc tgctactgct ggattagcgc caggaatgtc gttgtctgct      480

gggtcttccc ctcttcattc ccccaagatt actccacata cttctcctgc tcccagaaga      540

agaagtcaca ctccaaatcc agcaagttac atggtgcctt ctagtgcctc tacatctgtt      600

aataatcctg tttctcagac tccgtcttct ggtcaggtga tccaaaagga aactgttggt      660

gggacgactt acttctatac agacacaact ccagcacctt tgactggaat ggtgtttcca      720

aactatcata tttatcctcc aactgcacct cacgttgctt atatgcaacc gaaagcaaac      780

gcaccttcct tcttcatggc tgatgaactc cgacaggagc tgatcaacag acatttaata      840

acaatggctc aaattgatca agcagatatg ccagcagttc ctacagaggt tgacagctac      900

catagcctat tccctctaga accactgcca cctcccaacc ggatacagaa atcaagtaat      960

tttggatata ttacatcttg ctacaaagct gtaaacagca aagatgatct gccatattgc     1020

cttcggagga tacatggttt tcgtcttgtt aacacaaagt gcatggtgtt ggtcgacatg     1080

tggaagaaaa ttcaacactc aaatatcgta actttgcgtg aagtatttac cactaaagca     1140

tttgctgagc cctctcttgt gtttgcatat gatttccatg ctggaggaga aactatgatg     1200

agcagacact ttaatgaccc taatgctgat gcctacttca ccaagagaaa gtggggtcag     1260

cacgagggac cattgcccag gcagcatgct ggattattgc cagaatctct tatttgggca     1320

tatattgtcc aactaagttc tgcattgcgt accattcata cagcaggttt ggcatgtcga     1380

gttatggatc caacaaagat tctgataact ggcaaaacaa ggttgcgagt aaattgtgtt     1440

ggagtttttg atgttttaac atttgataac agtcaaaata ataatccatt ggcattaatg     1500

gcccagtacc agcaagcaga tctgatatca ttaggaaaag ttgtgttggc tttggcttgc     1560

aactctttgg caggaattca gcgagagaat ttacagaaag ccatggaact ggtgacaatc     1620

aactattcct ctgacctgaa gaatctgatt ttgtatttgt tgactgacca aaacaggatg     1680

cgaagtgtaa atgacatcat gcccatgatt ggtgctcgat tttatactca attggatgct     1740

gctcaaatga gaaatgatgt catagaggaa gaccttgcaa aggaggttca aaatggaaga     1800

ctgtttaggc tcctagcaaa attgggaaca atcaatgaga ggccggagtt tcagaaggat     1860

cccacttggt cagagactgg agaccgttat ctgttgaaac tctttaggga tcatcttttt     1920

catcaggtga cagaagcagg tgctccctgg attgacctca gtcatataat ttcttgtctt     1980

aacaagctag atgctggtgt gccagaaaaa ataagcctga tttccagaga tgagaagagt     2040

gtacttgtgg tgacctacag tgacttaaag cgctgctttg aaaatacttt tcaagaactg     2100

attgcagctg caaatggtca gttgtagtat ttgctaaaaa agcacgcagg acatggctaa     2160

agaccttaac caatagcaaa ttgcactaca gctgaacttt tcatcatctc attcacattt     2220

gggaaacgaa caggagatga gcaaagctgc ttgcacttca gtcaggtaca ctgttacttg     2280

aaaggaagaa tgtttcactt acccaagagc tatggctgcc attggaggct gttatctgtg     2340

aagaatttat tttagattta ggagcaccat caggtgaatg atgttcctgc ttttgttttt     2400

tccacttgta tatgcactaa ttttaatttt ttaaagactt tttctgatct ttgaactttt     2460

gccacattgt atacttataa tgggaaactt tgcaaggaca tttttgggaa gcaatgctgg     2520

gcagcgtttt tgccattgag ggttgcagaa tttgctcttt ttgggatggg ttgccctgaa     2580

taacattacg gaccaggtaa ataatttcat agaagttcag tatagtacgt aattcttgta     2640

agagtatcgt atgcaagctc tctgtatgcc acccactgtt agttcaaatt gagatttttg     2700

ttttgttttg ttcttaagaa cataccaaga aaataccagt gaattgttgg atatgaattc     2760

cctgttagtt gatttaaatc ctttctgaat aaagatcaga taaacagtaa ctgaaggagc     2820

atgtatagct ctttccttca aattcaacta gagccttttt aaaaagacat ttgcctgcta     2880

gtcagataca tttacattta tgcaaatttt ttaaatagga gaaaattaag aaattgtgtt     2940

aaaggcctaa agttcaggag tgtattactt taggttcttt ccagtttgct ggtttttttt     3000

tttttttttt tttttttttt tgggcggggg ggaggtttat gaagttttgc tctttgaacc     3060

acagctttat tatggtcctt tacactggag acagacacag agacactgtt cagaagatga     3120

actaaactca gcagtggtct ggtatcaaga gctttctgat gttttacagc ctgaatttgg     3180

agggataacg atctgctgtg cctttgcagt cactgcttag cccaaagtaa tagtactttt     3240

gataataact cactctgtgc gatattcctg aataagtcca tctcaaaagt ttgggatttt     3300

cctcctctta actttcttaa tatttggaca tgcagttgtc gccaaacttg ggtattcatg     3360

gaatttctag taaatgaaat acctatactt tgatactgaa gactgccaaa tacataggaa     3420

ttttctttct taaaaaacag taatgaagac tatatctcct ttcccagcac tgaatgtttt     3480

actagcactg ggtgctcacc atgcaactga agaaaatgtg gaaactcaaa aggtcaggac     3540

agacttccaa gcacttgcaa ctgatgttac tgtcttcaat tttaataatt acacatattt     3600

gtatatttca gagaagtttt taatatttct ctgtccactt tttataagct ttaaaatgat     3660

tttctctgcc ttgagatttg catcaagaaa aagcacctct cttcacctga aagctttgaa     3720

gactagagac acgctttaca cgttttaaca agtatattga gtccacgttt ggtagcatca     3780

gttgttgagt taaaaagaaa attattgcat ttgatctgga tggattttaa aagaatataa     3840

tgttcaatat taaaaggata attcacattt gccaccataa tgttcttttt tatgtaaaaa     3900

gaagaacttg gagacattaa catgaaaaag tcttttatca ttagctcatg tatttgagga     3960

agagcagctg tctttttata tgttttttga caaatcatat tgtattcttt tgtacaaaaa     4020

agaactactt gtattctaga agaaatatga aatgcttaat ttataagcgg gctggagatt     4080

ttttccaata ttgttttctt tgaaaatgaa aggggatcat ctattttagt tttggggtct     4140

gggaactttt tgaaaattta atttgtggac caatgttttg tgaaagctaa agagggcagg     4200

ggttaaaata gggcttgaat ttctcattct gtatagacca gcaaacttcc ctgtgcaagg     4260

caagtttaca tcacaaatcc aagaatgttt gcatcctaaa tgctagtttg cttcagcccc     4320

tagttaacct caggacttgg tttgcatata aaaggtagac agctgatatg ttttcatgaa     4380

taaatattgt cagccagaaa aggttggtgt caggtaatgc atattttttt aagctttgtt     4440

ttatatttat ttttcattta gtttttattg ggaatggttt tcaaagaact ctcagttctg     4500

cctaggtgtt tttgggggag ccctgttttc catagtgtaa ttccatttaa gaggttgtct     4560

aaaagtcttt ttaattaata gaaagatttt aatatccaag agtagtcaaa ttaaggatat     4620

aaactttcca caccttcctg tcgtgacaga taaaagcaca gaaaggacaa cccttgaaat     4680

catgtaacgt tggtcatttc aatattttgt acctgtttta aattctgtta gtgtatttac     4740

ttcattgtaa atatttttga gggtaccttt gtattttgct tttgaccttg gttctgtgat     4800

ttggatgtca acaacttccc taaaaagcac cagtgtgtta ggttctaatg tcatgaccca     4860

atttgtgtta ttcatcttta atcctgtttt cagtctctat gtgtacagca gtatttttaa     4920

taaagaatta cagagataaa                                                 4940


<210> 2539
<211> 7607
<212> DNA
<213> Homo sapiens

<400> 2539
agatttgaat acttcactga ggcgagccgg gcgttgtgag cggactgcta gaggcggctg       60

tctgtttccg ctctaaggaa actcagagcg tgtggacccc aaacaagtct gcgcaaaatt      120

tgtcgaggag gtttgccgcg gcagaaaagt tttcttcaaa aatggatggg gtgtcttcag      180

aggctaatga agaaaatgac aatatagaga gacctgttag aagacggcat tcttcaatat      240

tgaaaccccc aaggagtcct cttcaggacc tcagaggtgg gaatgaaaga gttcaggaat      300

ccaatgcttt gagaaataag aaaaactctc gtcgagtcag ctttgcagat actataaagg      360

tattccagac ggagtctcat atgaaaatag tgagaaagtc agaaatggaa gaaacagaaa      420

caggagaaaa tcttcttttg atacagaata agaaattaga agataattac tgtgaaatta      480

ctgggatgaa cacattgctt tctgctccca ttcataccca gatgcaacag aaggagtttt      540

caattataga acatacccgt gaaaggaaac atgcaaatga ccagacagtc attttttcag      600

atgaaaacca gatggacctg acatcaagtc acactgtaat gattaccaaa ggccttttag      660

ataatcccat aagtgaaaag tccaccaaga tagataccac atcatttcta gctaatttaa      720

agcttcacac cgaggactca agaatgaaaa aagaagtaaa tttttccgtg gatcaaaaca      780

cttcttcaga aaataaaata gatttcaatg acttcataaa aagattgaaa acaggaaaat      840

gtagtgcttt tcctgatgtg cctgataaag aaaattttga gatacctatt tattccaagg      900

aaccgaacag tgcctcttct acacatcaaa tgcatgtatc tcttaaggaa gatgaaaata      960

acagtaatat tactaggctc tttagagaaa aagatgatgg gatgaatttc acccagtgtc     1020

atacagccaa tattcagaca ttgattccca catccagtga gaccaactca cgggaatcta     1080

aaggtaatga tattacaatt tatggcaatg actttatgga cttgacattt aaccacactt     1140

tgcagatctt acctgcaaca ggtaattttt ctgaaataga aaatcaaact cagaatgcca     1200

tggatgtaac aacaggttat ggaactaaag cttcaggaaa taaaacagtt tttaagagta     1260

aacaaaatac tgcttttcaa gacctttcca taaactctgc agacaaaata catattacca     1320

gaagtcatat tatgggggca gaaactcaca tagtctcaca gacttgtaat caggatgcca     1380

gaatattagc catgacccca gaatctatat attctaatcc atctattcaa ggttgtaaga     1440

ctgttttcta ttctagttgt aatgatgcca tggaaatgac caaatgtctc tcaaatatga     1500

gagaggagaa aaatttgcta aagcatgaca gtaattatgc taaaatgtat tgcaatccag     1560

atgctatgtc ttctctcaca gagaaaacta tttattccgg agaggagaac atggacatta     1620

ccaagagtca tacagttgca atagataatc aaatttttaa acaagatcaa tcaaatgtgc     1680

aaatagcagc tgcaccaaca cccgaaaaag aaatgatgct ccaaaatctt atgaccacat     1740

cagaagatgg gaaaatgaat gtaaattgta actcagttcc tcatgtatct aaggaaagaa     1800

tacagcagag cctgtcaaat cctttgtcta tttcattgac tgatagaaag actgaactct     1860

tatcaggtga aaatatggat ttgactgaaa gtcacacaag taacttagga agtcaggttc     1920

ctcttgcagc ttataatcta gcaccggaga gtaccagtga atctcactct cagagcaaaa     1980

gctcttcaga tgaatgtgaa gaaattacca aaagtcgtaa tgaaccattt cagcgatcag     2040

acataatagc caaaaacagc ttaaccgaca cctggaacaa agacaaagat tgggttttga     2100

agattttgcc ctaccttgat aaagattctc ctcagtcagc tgattgtaat caggagatag     2160

caacaagcca taatatagtc tactgtggtg gagttcttga taaacaaata actaatagaa     2220

atacagtatc atgggaacaa tctttgtttt ctaccacaaa gccattattt tcatcaggac     2280

agttctctat gaaaaatcat gatactgcta taagtagtca tacagtgaaa tctgtactag     2340

gccagaattc taaactggct gagccactga ggaaaagttt aagcaatccc acacctgact     2400

attgccatga caagatgatt atatgttcag aggaagagca aaatatggat ctaacaaaga     2460

gccacactgt cgtcattgga tttggtcctt ctgaactaca agaacttggt aaaactaatt     2520

tagaacacac tactggccag ctaacaacaa tgaacagaca gatagctgta aaagttgaaa     2580

aatgtggtaa aagtcccata gaaaaaagtg gagtgcttaa atctaactgt attatggatg     2640

tgttagagga cgaaagtgta cagaaaccta aatttccaaa ggaaaagcaa aatgtcaaaa     2700

tttggggaag gaaaagtgtt ggtggaccaa aaattgataa gactattgta ttttcagaag     2760

acgataagaa tgatatggat atcactaaga gttatacaat agaaataaac catagacctt     2820

tattagagaa acgtgattgt catttggtgc cattggcagg aacttctgaa actattttat     2880

atacatgtag gcaggatgac atggagatca ctagaagtca cacaactgcc ttagaatgta     2940

aaactgtctc accagatgaa ataactacta ggcctatgga caaaactgta gtgtttgtag     3000

ataatcatgt tgaactagaa atgacagagt cccatactgt tttcattgac taccaagaaa     3060

aggaaagaac agacagacct aactttgaac tatcccaaag gaaaagccta ggaacaccaa     3120

cagtgatatg tactcctact gaggagagtg ttttctttcc aggaaatggt gaaagtgacc     3180

gtctagtagc aaatgacagc cagctaaccc ctctggagga atggtctaat aataggggcc     3240

ctgtagaggt agctgataac atggaattgt ctaaatcagc cacttgcaaa aacatcaaag     3300

atgtacaaag tcctggattt ctgaatgaac ctctatcaag caaaagtcag agaagaaaaa     3360

gccttaagct aaaaaatgac aagaccattg tattttcaga gaatcataaa aatgatatgg     3420

atattaccca gagttgtatg gtggaaatag ataacgaaag tgccctggag gataaagagg     3480

acttccattt ggcaggggct tctaaaacta ttttgtattc atgtgggcag gatgacatgg     3540

agatcactag gagtcacaca actgccttag aatgtaaaac tctcctgcca aatgaaatag     3600

ctattaggcc catggacaaa accgtattgt tcacagataa ttacagtgat ctggaagtca     3660

ccgattccca tactgttttc attgactgtc aagccacaga gaaaatactt gaagaaaacc     3720

ctaaatttgg aataggaaaa ggaaaaaact tgggtgtttc ctttcctaag gataatagct     3780

gtgttcaaga aatcgctgaa aaacaagcac tggctgtagg aaacaaaata gttcttcaca     3840

ccgagcaaaa gcaacaactc tttgctgcta ctaatagaac tactaatgaa atcatcaaat     3900

ttcatagtgc tgctatggat gaaaaggtca tagggaaagt tgtagaccag gcctgtacat     3960

tggaaaaagc gcaagttgaa agctgtcagt taaataatag agatagaaga aatgtggact     4020

ttacaagtag tcatgcaact gctgtttgtg gatccagtga taattattcc tgtttaccaa     4080

atgttatttc ctgtactgat aatttggagg gtagtgccat gctcttatgt gataaagatg     4140

aggaaaaagc caattattgc ccagtgcaaa atgatcttgc ttatgcaaat gattttgcca     4200

gtgaatatta cttggaatct gagggacagc ctctctctgc tccttgtcct ttgttagaga     4260

aggaagaagt tattcaaacc agtaccaaag gacagttaga ctgtgttata acactgcaca     4320

aagatcaaga tctgattaag gatccacgaa atctattggc taatcaaact ttagtatata     4380

gtcaagatct gggggagatg actaaactta attcaaagcg agtatctttt aagcttccaa     4440

aggatcaaat gaaagtctat gttgatgaca tttatgttat tcctcagcct catttctcaa     4500

ccgaccaacc tccattacct aaaaaaggac agagtagtat caataaagaa gaagtaatac     4560

tgtctaaagc tggaaataag agtttaaata ttatagaaaa ttcctctgca cccatatgtg     4620

aaaacaagcc caaaatactc aatagtgagg aatggtttgc tgcagcctgt aaaaaagaac     4680

tgaaggaaaa tattcaaaca actaactata atacagctct agatttccac agtaactcag     4740

acgtaactaa gcaagtcatt caaactcatg tcaatgctgg agaagcacca gatcctgtaa     4800

ttacatctaa tgttccatgt tttcatagta tcaaaccaaa tctgaataat ttgaatggaa     4860

aaactggaga gtttttagcc tttcaaactg ttcatctacc accccttcca gagcaattac     4920

ttgaattagg aaataaggca cacaatgata tgcatatagt gcaagctaca gaaatacata     4980

atattaacat aatctccagc aatgctaaag atagtagaga tgaggaaaat aaaaagtctc     5040

ataatggagc tgaaaccacc tctctaccgc caaagacagt ttttaaagat aaagtaagga     5100

gatgttcttt gggaatcttt ttgcctagat tgcccaacaa gagaaattgt agtgtcactg     5160

gtattgatga cctggaacag attccagcag acacaactga tataaatcac ttagaaactc     5220

agccggtctc tagcaaagat tcaggcattg gatctgttgc aggtaaactg aacctaagtc     5280

cttctcaata tataaatgag gaaaatcttc ctgtatatcc tgatgagatc aattcttcag     5340

actctattaa catagaaact gaggaaaagg ccttgattga gacataccaa aaagagattt     5400

caccatatga aaataaaatg ggaaaaactt gcaatagcca aaaaagaacg tgggtacaag     5460

aagaagaaga tattcataag gagaaaaaaa tcagaaaaaa tgagattaag tttagtgata     5520

cgacacaaga tcgggagatt tttgatcacc atactgaaga ggatatagat aaaagtgcta     5580

acagtgtatt gataaaaaac ctgagcagga ccccatctag ttgcagcagc tctctggatt     5640

caatcaaggc tgatgggacc tctctggact tcagcactta ccgcagtagt caaatggaat     5700

cacagtttct cagagatact atttgtgaag agagcttgag ggagaaactc caagatggga     5760

gaataacaat aagggagttc tttatacttc tccaggtcca catcttgata cagaaacccc     5820

gacagagcaa tctcccaggc aattttactg taaacacacc acctactcca gaagacctga     5880

tgttaagtca atatgtttac cgacccaaga tacagattta tagagaagat tgtgaggctc     5940

gtcgccaaaa gattgaagaa ttaaagcttt ctgcatcgaa ccaagataag ctgttggttg     6000

atataaataa gaacctgtgg gaaaaaatga gacactgctc tgacaaagag ctgaaggcct     6060

ttggaattta tcttaacaaa ataaagtcat gttttaccaa gatgactaaa gtcttcactc     6120

accaaggaaa agtggctctg tatggcaagc tggtgcagtc agctcagaat gagagggaga     6180

aacttcaaat aaagatagat gagatggata aaatacttaa gaagatcgat aactgcctca     6240

ctgagatgga aacagaaact aagaatttgg aggatgaaga gaaaaacaat cctgtggaag     6300

aatgggattc tgaaatgaga gctgcagaaa aagaattgga acagctgaaa actgaagaag     6360

aggagcttca aagaaatctc ttagaactgg aggtacaaaa agagcagacc cttgctcaaa     6420

tagactttat gcaaaaacaa agaaatagaa ctgaagagct actggatcag ttgagcttgt     6480

ctgagtggga tgtcgttgag tggagtgatg atcaagctgt attcaccttt gtttatgaca     6540

cgatacaact caccatcacc tttgaagagt cagttgttgg tttccctttc ctggacaagc     6600

gttataggaa gattgttgat gtcaattttc aatctctgtt agatgaggat caagctcctc     6660

cttcctccct tttagttcat aagcttattt tccagtacgt tgaagaaaag gaatcctgga     6720

agaagacatg tacaacccag catcagttac ccaagatgct tgaagaattc tcactggtag     6780

tgcaccattg cagactcctt ggagaggaga ttgagtattt aaagagatgg ggaccaaatt     6840

ataacctaat gaacatagat attaataata atgaattgag acttttattc tctagctccg     6900

cagcatttgc aaagtttgaa ataactttgt ttctctcagc ctattatcca tctgtaccat     6960

taccttccac cattcagaat cacgttggga acactagcca agatgatatt gctaccattc     7020

tatctaaagt gccactggag aacaactacc tgaagaatgt agtcaagcaa atttaccaag     7080

atctgtttca ggactgccat ttctaccact agacccttgg accaccattg gaacaaccaa     7140

gcagaatgta cttgatatta tttcagggtc ccattgctgt tcagcctttg tttttacgtc     7200

attacaagct gagtaaaatt ccttctgatg atgttatagt taatctgtat gttttttata     7260

tctctgcaga atgatggtga tgaagtctgg atggtaggcc tcatagccta ctatcaactt     7320

actcatcttt gtaccaaagg tttaagtaat aggacactta ggaaaaatgt ctcctaacta     7380

aactagtgct ttctgcttta gtacaagccc taaggattaa cttaagtata agaagtgtta     7440

tcactgacaa gaacattagc cattttccca taactagata gagctatgat tttttaggtt     7500

gcctggcttc tgcctagcag atatttctgg agtagaaatg tatctgtcta caaactatta     7560

tcctttttct ccgttactaa aatgctatta agagaaagta gggctgg                   7607


<210> 2540
<211> 1128
<212> DNA
<213> Homo sapiens

<400> 2540
tgctcctcta cctgctccac cctcaatcca ccagaaccat gggctgctgt ggctgctccg       60

gaggctgtgg ctccggctgt ggaggccgtg gctccggctg tgggggctgt ggctccggct      120

gtggaggctg tggctctggc tgtgggggct gtggctccgg ctgtggaggc tgtgggggct      180

gtggctccgg ctgtgcgggc tgtgggggat gtggctccgg ctgctgtgtg cctgtctgct      240

gctgcaagcc catgtgctgc tgtgtgccag cttgttcctg ctccagctgt ggcaaagggg      300

gctgtggctc ttgcgggggc tccaagagag gctgtgtctc ctgtggggtg tccaaggggg      360

cctgtggctc ctgtgggggg tccaaggggg gctgtggctc ctgtgggggg tccaaggggg      420

gctgtggctc ctgtgggggg tccaaggggg gctgtggctc ctgtgggggg tccaaggggg      480

gctgtggttc ttatggctgc tcccagtcca gctgctgcaa gccctgctgc tgctcctcag      540

gctgtgggtc atcctgctgc cagtccagct gctgtaagcc ttactgctgc cagtccagct      600

gctgtaagcc ctactgctgc cagtccagct gctgtaagcc ctgtagctgc ttctcaggct      660

gtggatcatc ctgctgccaa tccagctgct acaagccctg ctgctgccag tccagctgct      720

gtgtccccgt gtgctgccag tgtaagatct gaggctctga ctgcagactg caggtggcct      780

gactggtgaa gggcccggct gcccagcttc cttgccctgg gttctctggt gctccactgt      840

ctccactgtg tcctcactgg cttcatccac tccacaccag tgctcccgaa actgactgag      900

gaccccttct ggctcattgc ctactacttc tcctgaactt cctctccctg ctcctcactc      960

atttaagatc caaagcggcc cactgaggcc ccagaggcag atcagacccc ttagaccctg     1020

acagctgctc cttctttcag gagtgtgatc gaccctcaat ctctctggct gtctgtatat     1080

caagactgaa tcctgaccct ctaaataaac aaagtctcta agcacaaa                  1128


<210> 2541
<211> 899
<212> DNA
<213> Homo sapiens

<400> 2541
gggctcagag aactccacac ctgcacacct ccctctcacc tgctcctcta cctgctccac       60

cctcaaccca ccagaaccat gggctgctct ggctgctctg gaggctgtgg ctccagctgt      120

gggggctgtg gctccagctg tgggggctgt ggctccggct atgggggctg tggctccggc      180

tgctgtgtac ctgtctgctg ctgcaagccc gtgtgctgct gtgtgccagc ctgttcctgc      240

tccagctgtg gctcctgtgg gggctccaag ggggtctgtg gctcttgtgg gggctgcaag      300

gggggctgtg gctcctgtgg aggctccaag gggggctgtg gctccagctg ctgtgtgccc      360

gtctgctgct cctccagctg tggctcctgt gggggttcca agggggtctg tggatttcgt      420

gggggctcca aggggggctg cggttcttgt ggctgctccc agtgcagctg ctataagccc      480

tgctgctgct cctcaggctg tgggtcatcc tgctgccagt ccagctgctg caagcccagc      540

tgctcccagt ccagctgctg taagccctgc tgttcccagt ccagctgctg taagccctgc      600

tgctgctcct caggctgtgg gtcatcctgc tgccagtcca gctgctgcaa accctgctgt      660

tcccagtcca gctgctgtaa gccctgctgc tgctcctcag gctgtgggtc atcctgctgc      720

cagtccagct gctgcaagcc ctgctcctcc cagtccagct gctgtgtccc aatttgctgc      780

cagtgcaaga tctgaggctc tgcccacaaa cctcagtggg tcctacagat ccgggctctc      840

caggaatgat tgcagctgtg tcctgaattc ctgaagcacg tctctgaatc tgtcctcct       899


<210> 2542
<211> 2384
<212> DNA
<213> Homo sapiens

<400> 2542
cctgctcgtt cctgacagaa ttaacggcac agccaacaag atgaacggag ctttggatca       60

ctcagaccaa ccagacccag atgccattaa gatgtttgtc ggacagatcc cccggtcatg      120

gtcggaaaag gagctgaaag aactttttga gccttacgga gccgtctacc agatcaacgt      180

cctccgggac cggagtcaga accctccgca gagtaaaggt tgttgtttcg taacatttta      240

tacaagaaaa gctgcacttg aggcccagaa tgcactgcac aatattaaaa ctttacctgg      300

gatgcatcat cccattcaga tgaaacctgc agatagtgaa aagtccaacg ctgtggaaga      360

cagaaaattg ttcataggaa tggtatcgaa gaaatgtaat gagaacgaca tcagggtgat      420

gttctctcca tttggccaga tagaagaatg ccggatcctc cggggacctg atgggctgag      480

tcgaggctgt gcgtttgtca cattttctac aagggcaatg gcacagaatg caatcaaagc      540

catgcatcag tctcagacca tggagggctg ctcttcacct atcgtggtga agtttgctga      600

cactcagaag gacaaagagc aaaggcgcct ccagcagcag ctcgctcagc agatgcagca      660

gctcaacact gccacctggg ggaacctgac agggctgggc ggactgaccc cacagtatct      720

ggcgctcctg cagcaggcca cctcctccag caacctgggt gcgttcagcg gcattcaaca      780

aatggcaggc atgaatgctt tacagttgca gaacctggcg acgctggctg ctgctgcagc      840

tgcggcccag acctcagcca ccagcaccaa tgcaaaccct ctctctacca cgagcagcgc      900

cctgggagcc ctcacgagtc ccgtggctgc ttcaaccccc aactccactg ctggtgcagc      960

catgaactcc ttgacctctc tcgggactct gcaaggactg gctggagcca ctgttggact     1020

gaataatatt aatgcactag cagttgctca aatgctctca ggtatggcgg ctctgaatgg     1080

aggacttggc gccacaggct tgacgaatgg cacggctggc accatggacg ccctcaccca     1140

ggcctactca ggaattcaac agtacgcagc cgccgcgctg cccactctgt acagccagag     1200

cctgctgcag cagcagagcg ctgcaggcag ccagaaggaa ggtccagagg gggcaaacct     1260

ctttatttac caccttccac aggaatttgg agaccaggac attctgcaga tgttcatgcc     1320

ttttggaaat gttatctctg ctaaagtctt cattgacaaa cagaccaatc tgagcaagtg     1380

ctttggtttt gttagctacg acaatccagt ctctgcacaa gctgctatcc aagctatgaa     1440

tggctttcag atcggcatga aacgcttgaa ggtgcagctg aagcgttcca aaaacgacag     1500

caaaccttac tgatcctaac cccagaggct ccctgctctc attttagctt tcttaggaca     1560

tcttcatgcc cgttagttca tcgtttgcct agcatgtccc tgtggcgtct caaaaaaaag     1620

tttcatcgtc ccgtcattgt ttctgatgtc tttctgacct cacatcatat ttggttctcc     1680

tactgacctt tgatctagtt tgacctttga aatttgcatg tgacctcatc tagctatgaa     1740

ttctgggaag tcaatgtgaa aaacattgct gcattcatgc aagactgaaa tttattatta     1800

gacaaattca ttatagaaaa aacctgtggc aaaaacgttt ctttcttatt ttttttcttt     1860

tcctaaaaca gacttgaaag tattatacag ggattggcat tcttcccggt cactggtaac     1920

aatagcaata tgtgtccagg gacacagaat gttggtttct aacagactac ttccaaaaac     1980

agtttgagaa aaaaactgtc tgattttaag tctctagagg tctgtaatag tttttacatt     2040

tttcaggcag tgtaaagttt tttgataagg ccattttagg tggctcactt tctcattaag     2100

atatatatat agaaccactt tttgtagatt agtataagaa aaatatttac cctgttttgg     2160

ggcaaatgct acctatttgt gtcacctttt gctgaactca cagttagaca atccatggtt     2220

taatgcacat gaaattacct atattttata ctgtttcaat gtacaggaga aaggttactg     2280

taaactgtgt tatgttggtg cttctgtgaa ttaagttgtg gtttcatcat gagtcttaat     2340

gttctttgtt gataagacaa gtttagaatt ggtttactta atac                      2384


<210> 2543
<211> 6104
<212> DNA
<213> Homo sapiens

<400> 2543
cttttgacta gtgttttaat gccatcattt ggctatttta ttagatcacc agagaagaga       60

gaacctattg ccttaataag aaaatctgat gtatcaagag gtaatttgga aaaagaaatg      120

gctcatctta accatgatct atattcagga gatttaaatg aacagtccca ggcacagcta      180

agtgaaggat caattacact tcaggttgaa gcagtagaga gtacttcaca agtggatgaa      240

aatgatgtga cgttaacggc tgataaaggc aaaacagagg acactttctt catgagcaac      300

aaaccccaaa gatacaaaga caagctacca gatagtggtg attctatgct taggatcagc      360

accattgctt cagccattgc agaggcatca gttaatactg atccttccca acttgctgca      420

atgatcaagg cactttcaaa taaaaccaga gacaagactt ttcaggaaga tgagaaacaa      480

aaggactatt ctcatgtgcg tcatttctta cctaatgatt tagaaaaaag taatggatcc      540

aatgcacttg atatggagaa ataccttaaa aaaacagaag ttagtagata tgaaagtgca      600

ttggaaaact tttcaagggc tagtatgtct gatacttggg atttatcttt gcccaaagaa      660

caaactactc aagacattca tccggtggac ttaagtgcta ctagtgtaag tgtgagggca      720

ccagaagaaa acacagcagc tattgtttat gttgaaaatg gagagagtga gaatcaagag      780

tcatttagaa ccataaactc ctcaaattca gttacaaata gagagaataa cagtgcagta      840

gttgatgtga agacatgttc cattgacaac aaattacaag atgttggtaa cgatgaaaaa      900

gctacctcaa tttccactcc atctgatagt tattcatcag tgaggaaccc cagaataaca      960

tccctttgtc tgttaaaaga ctgtgaagaa atacgagata acagagaaaa tcagaggcaa     1020

aatgagtgtg tcagtgaaat aagcaacagt gagaagcatg tgacttttga aaaccatcgc     1080

atagtctcac ctaaaaatag tgatttgaaa aatacctctc ctgagcatgg tggacgtggc     1140

tcagaggatg agcaggagag cttcagacct tccacgtcac cactgagtca ttcttctcct     1200

agtgaaattt ctggaacgag ttcatcaggg tgtgcgttag agtcctttgg ttcagcagct     1260

cagcagcagc agcctccctg tgagcaggag ttgtctccct tggtgtgctc gcctgctggg     1320

gtgagcaggc tgacgtatgt gtctgaacca gagagctcct atcctaccac agccacagat     1380

gatgccctgg aggaccgcaa gagtgatatc accagcgagt tgagtaccac aattattcaa     1440

ggcagtccag ccgcattgga ggaacgggct atggaaaaat tgagagaaaa agttccattt     1500

cagaatagag gaaaaggaac attatcatct attatccaga ataactctga tacaagaaaa     1560

gcaactgaaa ctacttctct gagtagcaag cctgaatatg taaaacctga ctttagatgg     1620

agtaaagatc cttcctccaa aagtggaaat ctgttggaaa ccagtgaggt aggttggaca     1680

tcaaaccctg aggaattgga cccgatcagg ctggctctcc tgggcaagtc aggtctgagc     1740

tgtcaggtgg ggtcagccac atcacaccct gtgtcctgcc aggagcctat agatgaagat     1800

caaagaataa gtcctaaaga taagtcaact gctggccgtg agttcagtgg ccaggtttct     1860

catcagacca cctctgaaaa ccagtgtact cctattccca gcagcacagt tcacagctct     1920

gtggctgaca tgcagaacat gcctgctgct gtgcacgcac tcttgacaca accctctctc     1980

agcgctgctc cttttgctca gcggtatttg ggaacactcc cttcaactgg aagcaccacc     2040

ttgcctcagt gccatgctgg caatgccaca gtctgtggct tctcaggagg ccttccctat     2100

ccagctgttg caggagagcc tgtgcagaac tctgtggctg tgggaatttg tctaggatca     2160

aatatcggct ctggatggat gggtacctct tccctctgta acccatattc taatacctta     2220

aatcagaacc tgctaagcac aacaaaacct tttcctgtgc cgtctgttgg tacaaactgt     2280

ggaattgaac catgggattc aggagtgaca tcaggattgg ggagtgtccg agtgcccgag     2340

gagttgaagc ttcctcatgc ttgctgtgtc gggatcgctt cccagaccct cctcagtgtg     2400

cttaatccaa ctgaccgctg gctgcaagtc agcattgggg tcctcagcat tagtgttaat     2460

ggtgaaaagg tggatctttc aacatatcgt tgtttagttt tcaagaataa agccatcata     2520

agacctcatg ccacagaaga gataaaagtg ctttttatac catccagtcc tggggttttc     2580

agatgcacat tcagtgttgc ttcttggcca tgttcgacag atgctgagac catcgtacag     2640

gcagaagctt tggccagcac cgtcactctc actgccattg ccgagagtcc tgttattgag     2700

gtagaaacag aaaagaaaga cgttcttgat tttggtgact tgacttatgg aggctggaaa     2760

gccctcccac taaaattgat aaaccgaacg catgccactg tgccaattag actgattatt     2820

aatgctaacg ctgtagcctg gcgctgtttc acgttttcca aggaatccgt ccgagctcct     2880

gtggaagttg ctccttgcgc tgatgtggtc actcggctag caggcccttc tgtggtcaac     2940

cacatgatgc ctgctagtta tgatggacag gatccagaat ttctgatgat ttgggttctt     3000

ttccatagtc caaagaaaca gatcagctct tcagatattc tggactcagc agaagaattc     3060

tcggcaaaag ttgatatcga agttgacagc ccaaacccta cgcccgttct tagaagtgtg     3120

agtctccgag caagagcagg aatagctagg atccatgctc ccagggactt gcagacgatg     3180

catttcttgg ccaaagtggc ttcctcaaga aagcagcact tacctttgaa aaatgctggg     3240

aacattgaag tttatttgga tatcaaggtc ccagaacaag gaagtcactt ttcagtggat     3300

ccaaagaatc tactccttaa acctggagaa gaacatgagg ttattgtttc atttactcca     3360

aaggatcctg aagcctgcga ggaaaggatc ttgaaaatat ttgtgcagcc atttggacct     3420

cagtatgagg tagtgttaaa aggcgaagtc atttcttcag gaagtaaacc tctgtcacct     3480

ggaccttgct tagatattcc atcgattttg tccaacaaac aatttctggc ttggggagga     3540

gtccctctag gtagaacaca gcttcagaaa ctagctttaa gaaataattc tgcatctaca     3600

actcaacatt tacgactgct tattagagga caagatcagg actgctttca gcttcagaac     3660

acttttggtt cagaacagcg attgaccagt aactgtgaga tcagaattca cccaaaggaa     3720

gacattttca tctctgtatt atttgcacct actcgattat cttgcatgtt ggctagacta     3780

gaaatcaaac aacttggaaa tcgatcacaa ccaggcatta agttcacaat acctttgtct     3840

ggatatggag gaacaagcaa tcttattttg gaaggcgtta aaaaattatc tgacagttac     3900

atggtaacag tgaatggctt agtacctggc aaagaaagta aaattgtttt ttctgtccgc     3960

aacactggct cccgagcagc ttttgttaaa gcagtaggtt ttaaggattc tcagaaaaaa     4020

gttttgctgg atcctaaagt attgaggatt tttccagata aatttgtact caaggaaaga     4080

acacaagaaa atgttacttt aatatataat ccatcagaca gaggaatcaa taataaaact     4140

gcaacagaac tatcaactgt atacttattt ggtggagatg aaatttcaag acagcagtat     4200

cgcagggccc tgttacataa accagagatg ataaaacaga tacttccaga acatagtgtg     4260

cttcaaaaca ttaattttgt tgaagcattt caagatgagc tattagtaac tgaagtatat     4320

gatcttcccc aacgacctaa tgatgttcag ctcttttatg gaagcatgtg taaaattata     4380

ctttcagtaa ttggagaatt cagagattgc atttctagca gagaattcct tcagccttct     4440

tccaaagcta gcttggaatc tacaagcgac ttgggagctt ctgggaaaca tggtggcaac     4500

gtctctttgg atgttttacc agtcaaaggt cctcagggtt ctcctcttct ctcacgggcg     4560

gctcgcccgc ctctggatca gctggcctcc gaagagccgt ggactgtcct acccgagcac     4620

ttgattctgg tagctccttc tccttgtgac atggcaaaaa ctggacgttt ccagattgtg     4680

aataactctg tgaggttact gagatttgag ctgtgctggc cagcgcattg cctcacagtc     4740

acgccgcagc atggatgtgt cgcgccagag agtaaactac aaattcttgt gagtcctaat     4800

tcctccttat ccacaaaaca gtcaatgttc ccgtggagtg gtttgatcta tatacactgt     4860

gacgatggac agaagaaaat tgtgaaagtt caaattcgag aagatttaac tcaagtggaa     4920

cttttaactc gtttgacctc caaaccattt ggaattcttt ccccagtatc tgagccttca     4980

gttagtcatt tggtcaaacc aatgacaaaa ccgccttcca caaaagttga aataagaaac     5040

aagagtatta cttttcctac aacagaacct ggtgaaactt cagagagctg tctagaactc     5100

gagaatcatg gcaccacaga cgtgaaatgg catctgtcat ctttagcgcc accttatgtc     5160

aagggagttg atgaaagtgg agatgttttt agagctacct atgcagcatt cagatgttct     5220

cctatttctg gtctgctgga aagccatggg atccaaaaag tctccatcac atttttgccc     5280

agaggtaggg gggattatgc ccagttttgg gatgttgaat gtcaccctct taaggagcct     5340

cacatgaaac acacgttgag attccaactc tctggacaaa gcatcgaagc agaaaatgag     5400

cctgaaaacg catgcctttc cacggattcc ctcattaaaa tagatcattt agttaagccc     5460

cgaagacaag ctgtgtcaga ggcttctgct cgcatacctg agcagcttga tgtgactgct     5520

cgtggagttt atgccccaga ggatgtgtac aggttccggc cgactagtgt gggggaatca     5580

cggacactta aagtcaatct gcgaaataat tcttttatta cacactcact gaagtttttg     5640

agtcccagag agccattcta tgtcaaacat tccaagtact ctttgagagc ccagcattac     5700

atcaacatgc ccgtgcagtt caaaccgaag tccgcaggca aatttgaagc tttgcttgtc     5760

attcaaacag atgaaggcaa gagtattgct attcgactaa ttggtgaagc tcttggaaaa     5820

aattaactag aatacatttt tgtgtaaagt aaattacata agttgtattt tgttaacttt     5880

atctttctac actacaatta tgcttttgta tatatatttt gtatgatgga tatctataat     5940

tgtagatttt gtttttacaa gctaatactg aagactcgac tgaaatatta tgtatctagc     6000

ccatagtatt gtacttaact tttacaggtg agaagagagt tctgtgtttg cattgattat     6060

gatattctga ataaatatgg aatatatttt aatgtggtat atcc                      6104


<210> 2544
<211> 108
<212> DNA
<213> Homo sapiens

<400> 2544
atgtgctact acggaaacta ctatggcggc tatggctatg gaggcctggg ctgtggctat       60

ggctcctgct gtggctgtgg cttccgcaga ctgggctgtg gctatggc                   108


<210> 2545
<211> 849
<212> DNA
<213> Homo sapiens

<400> 2545
cagctgaact cacatctccc gtcaacatgt cctacaactg ctgctctgga aacttctcct       60

cccgctcctg tggtgactac ctgcgctacc cagcatcctc acgtggcttt tcctacccca      120

gcaatctggt ctacagcact gacctctgct ctcccagcac ctgccagctg ggttcctctc      180

tctatagggg ctgtcaggag atctgctggg agcccaccag ctgccagacg tcctatgtgg      240

agtccagccc ctgccagacc tcctgctacc gccccagaac ctccttgctc tgcagtcctt      300

gcaagacgac ttactctggg tctctaggct ttggatccag cagctgccgc tccctgggct      360

atggatcgag gagctgctac tcagtgggct gtgggtccag tggtgtcaga tccctgggtt      420

atggaagctg tggcttccct tccctcggct atggatctgg attctgccgc ccaacctact      480

tggcttctag gagctgccag tctccttgtt acagaccagc ctatggatca accttctgca      540

gatcaacttg ctgaatttcc agacctttta agcaaagtgt ctcagtctct acgtagagct      600

gttatcatag gcatttccag caatgtgagc taacccctct tactactagc tcttcatcct      660

ttctctggca tcaagtactg gctggacagg ctagttcttt cagactgtga aattaatgaa      720

tgagcaaaat atagagtcaa atgtctataa ttttgaaaca agtgattcgt tatcacgtaa      780

gttcatctta taaagtatat ggaagttcag ttttgtttca cgtaataaat tcatttactg      840

ttgattcca                                                              849


<210> 2546
<211> 581
<212> DNA
<213> Homo sapiens

<400> 2546
tttccagggg tcactctggc ttcgactccg tcgctctcaa ttcgtcacca ggaggaagac       60

ggagctggct gcccagccca aaggcccatg aggggatgca gttatgggct ctgtcgccgt      120

ggagatagag tgtcgctttg ttgcccaggc tagtcttgaa cttctggcct caagccgtcc      180

tcccacctcg atctcccaaa gtgttgggat tacaggcatt gttattttgt gtcagtaagt      240

aatccataaa gtgccaacat gggaaagaaa cggacaaagg gaaaaactgt tccaatcgat      300

gattcctctg aaactttaga acctgtgtgc agacacatta gaaaaggatt ggaacaaggt      360

aatttgaaaa aggctttagt gaatgtggaa tggaatatct gccaagactg taagactgac      420

aataaagtga aagataaagc tgaagaagaa acagaagaaa agccttcagt ttggctgtgt      480

cttaaatgtg gccatcaggg ctgtggcaga aattctcagg agcagcatgc cttgaagcac      540

tatctgacgc caagatctga acctcactgt ctggttctta g                          581


<210> 2547
<211> 2960
<212> DNA
<213> Homo sapiens

<400> 2547
ataatgccgc gttccggaag ttattgcttt ccaggggtca ctctggcttc gactccgtcg       60

ctctcaattc gtcaccagga ggaagacgga gctggctgcc cagcccaaag gcccatgagg      120

ggatgcagtt atgggctctg tcgccgtgga ttgttatttt gtgtcagtaa gtaatccata      180

aagtgccaac atgggaaaga aacggacaaa gggaaaaact gttccaatcg atgattcctc      240

tgaaacttta gaacctgtgt gcagacacat tagaaaagga ttggaacaag gtaatttgaa      300

aaaggcttta gtgaatgtgg aatggaatat ctgccaagac tgtaagactg acaataaagt      360

gaaagataaa gctgaagaag aaacagaaga aaagccttca gtttggctgt gtcttaaatg      420

tggccatcag ggctgtggca gaaattctca ggagcagcat gccttgaagc actatctgac      480

gccaagatct gaacctcact gtctggttct tagtttggac aactggagtg tatggtgtta      540

cgtatgtgat aatgaggtcc agtattgtag ttcaaaccag ttgggtcaag tggttgatta      600

tgtcagaaaa caagccagca ttacaactcc aaagccagag aaagataatg gaaatattga      660

acttgaaaat aaaaaattag aaaaagagag taagaatgaa caagagagag aaaagaagga      720

aaacatggct aaagagaatc ctcccatgaa ttctccttgc caaataaccg tgaaaggact      780

cagtaatttg ggaaacacat gtttcttcaa tgcagttatg cagaacttgt cacaaacacc      840

agtgcttaga gaactactaa aagaagtgaa aatgtctgga acaattgtaa aaattgaacc      900

acctgatttg gcattaacag aaccattaga aataaacctt gagcctccag gccctcttac      960

tttagccatg agccagtttc ttaatgagat gcaagagacc aaaaaggggg ttgtgacacc     1020

gaaagaactc ttttctcagg tctgtaaaaa agcagtgcgg tttaaaggct atcagcagca     1080

agacagccag gagctgcttc gctacttatt ggatgggatg agagcagaag aacaccaaag     1140

agtgagtaaa ggaatactta aagcatttgg taattctact gaaaagttgg atgaagaact     1200

aaaaaataaa gttaaagatt atgagaagaa aaaatcaatg ccaagttttg ttgaccgcat     1260

ctttggtggt gaactaacta gtatgatcat gtgtgatcaa tgcagaactg tctccttggt     1320

tcatgaatct ttccttgatt tgtccctccc agttttagat gatcagagtg gtaagaaaag     1380

tgtaaatgat aaaaatctga aaaagacagt ggaggatgaa gatcaagata gtgaggaaga     1440

aaaagataac gacagttaca taaaagagag aagtgatatt ccttctggaa caagtaagca     1500

cttacagaaa aaagcaaaga aacaagccaa aaagcaagcc aagaaccaac gaagacaaca     1560

aaaaattcaa ggaaaagttc ttcatttaaa tgatatttgt actattgacc atcctgaaga     1620

cagtgaatat gaagctgaaa tgtcacttca aggagaagta aatattaaat ccaaccatat     1680

ttcacaagag ggtgttatgc ataaagaata ttgtgtcaac cagaaagatt tgaatggcca     1740

agcaaaaatg atcgaaagtg taactgacaa tcaaaaatcc acagaggaag tagatatgaa     1800

aaatatcaac atggataatg atctggaggt tttaacatct tctcccacta ggaatttaaa     1860

tggtgcctac ctaacggaag ggagcaatgg agaagtggac atttccaatg gtttcaaaaa     1920

cctaaatttg aatgctgctc ttcatcctga tgaaataaat atagagattc tgaatgatag     1980

tcatactcct ggaacaaagg tgtatgaggt tgtaaatgaa gatccagaaa ctgctttctg     2040

tactcttgca aacagggaag ttttcaatac tgatgagtgt tcaatccaac attgtttata     2100

tcagttcacc cgtaatgaga aacttcgaga tgcgaataaa ctgctttgtg aagtatgcac     2160

acggagacag tgtaatggac caaaggcaaa tataaaaggt gaaaggaagc atgtttacac     2220

caatgccaaa aagcagatgc taatttctct tgctcctcct gttcttactc ttcatttaaa     2280

gagatttcag caggctggtt ttaacctacg caaagttaac aaacacataa agtttccgga     2340

aatcttagat ttggctcctt tttgcaccct taaatgtaag aatgttgcag aagaaaatac     2400

aagggtactc tattccttat atggagttgt tgaacacagt ggtactatga ggtcggggca     2460

ttacactgcc tatgccaagg caagaaccgc aaatagtcat ctctctaatc ttgttcttca     2520

cggtgatatt ccacaagatt ttgaaatgga atcaaaaggg cagtggtttc acatcagcga     2580

cacacatgtg caagctgtgc ctacaactaa agtactaaac tcacaagcgt acctcctatt     2640

ttatgagaga atactgtaat aatatcaaaa gcactttttc tggaaacaca tttatggctt     2700

ttataatggc tgaaataacg ataaaaaaag actaattaaa atcatgttca cttaacatta     2760

aatacatgcc agaagaaatc atgtttattt aaatattgaa gggaaaaata cctaaaaatg     2820

tacaaaggtt ttatattgtc atagtggttt ttattcctgc tttgtttctg gaaaggaaat     2880

cctgaattac ttaagtactt tgtgtttaat atatctgggt gatggatcac aacacatcaa     2940

taaactgact taccctaaaa                                                 2960


<210> 2548
<211> 2963
<212> DNA
<213> Homo sapiens

<400> 2548
ataatgccgc gttccggaag ttattgcttt ccaggggtca ctctggcttc gactccgtcg       60

ctctcaattc gtcaccagga ggaagacgga gctggctgcc cagcccaaag gcccatgagg      120

ggatgcagtt atgggctctg tcgccgtgga ttgttatttt gtgtcagtaa gtaatccata      180

aagtgccaac atgggaaaga aacggacaaa gggaaaaact gttccaatcg atgattcctc      240

tgaaacttta gaacctgtgt gcagacacat tagaaaagga ttggaacaag gtaatttgaa      300

aaaggcttta gtgaatgtgg aatggaatat ctgccaagac tgtaagactg acaataaagt      360

gaaagataaa gctgaagaag aaacagaaga aaagccttca gtttggctgt gtcttaaatg      420

tggccatcag ggctgtggca gaaattctca ggagcagcat gccttgaagc actatctgac      480

gccaagatct gaacctcact gtctggttct tagtttggac aactggagtg tatggtgtta      540

cgtatgtgat aatgaggtcc agtattgtag ttcaaaccag ttgggtcaag tggttgatta      600

tgtcagaaaa caagccagca ttacaactcc aaagccagca gagaaagata atggaaatat      660

tgaacttgaa aataaaaaat tagaaaaaga gagtaagaat gaacaagaga gagaaaagaa      720

ggaaaacatg gctaaagaga atcctcccat gaattctcct tgccaaataa ccgtgaaagg      780

actcagtaat ttgggaaaca catgtttctt caatgcagtt atgcagaact tgtcacaaac      840

accagtgctt agagaactac taaaagaagt gaaaatgtct ggaacaattg taaaaattga      900

accacctgat ttggcattaa cagaaccatt agaaataaac cttgagcctc caggccctct      960

tactttagcc atgagccagt ttcttaatga gatgcaagag accaaaaagg gggttgtgac     1020

accgaaagaa ctcttttctc aggtctgtaa aaaagcagtg cggtttaaag gctatcagca     1080

gcaagacagc caggagctgc ttcgctactt attggatggg atgagagcag aagaacacca     1140

aagagtgagt aaaggaatac ttaaagcatt tggtaattct actgaaaagt tggatgaaga     1200

actaaaaaat aaagttaaag attatgagaa gaaaaaatca atgccaagtt ttgttgaccg     1260

catctttggt ggtgaactaa ctagtatgat catgtgtgat caatgcagaa ctgtctcctt     1320

ggttcatgaa tctttccttg atttgtccct cccagtttta gatgatcaga gtggtaagaa     1380

aagtgtaaat gataaaaatc tgaaaaagac agtggaggat gaagatcaag atagtgagga     1440

agaaaaagat aacgacagtt acataaaaga gagaagtgat attccttctg gaacaagtaa     1500

gcacttacag aaaaaagcaa agaaacaagc caaaaagcaa gccaagaacc aacgaagaca     1560

acaaaaaatt caaggaaaag ttcttcattt aaatgatatt tgtactattg accatcctga     1620

agacagtgaa tatgaagctg aaatgtcact tcaaggagaa gtaaatatta aatccaacca     1680

tatttcacaa gagggtgtta tgcataaaga atattgtgtc aaccagaaag atttgaatgg     1740

ccaagcaaaa atgatcgaaa gtgtaactga caatcaaaaa tccacagagg aagtagatat     1800

gaaaaatatc aacatggata atgatctgga ggttttaaca tcttctccca ctaggaattt     1860

aaatggtgcc tacctaacgg aagggagcaa tggagaagtg gacatttcca atggtttcaa     1920

aaacctaaat ttgaatgctg ctcttcatcc tgatgaaata aatatagaga ttctgaatga     1980

tagtcatact cctggaacaa aggtgtatga ggttgtaaat gaagatccag aaactgcttt     2040

ctgtactctt gcaaacaggg aagttttcaa tactgatgag tgttcaatcc aacattgttt     2100

atatcagttc acccgtaatg agaaacttcg agatgcgaat aaactgcttt gtgaagtatg     2160

cacacggaga cagtgtaatg gaccaaaggc aaatataaaa ggtgaaagga agcatgttta     2220

caccaatgcc aaaaagcaga tgctaatttc tcttgctcct cctgttctta ctcttcattt     2280

aaagagattt cagcaggctg gttttaacct acgcaaagtt aacaaacaca taaagtttcc     2340

ggaaatctta gatttggctc ctttttgcac ccttaaatgt aagaatgttg cagaagaaaa     2400

tacaagggta ctctattcct tatatggagt tgttgaacac agtggtacta tgaggtcggg     2460

gcattacact gcctatgcca aggcaagaac cgcaaatagt catctctcta atcttgttct     2520

tcacggtgat attccacaag attttgaaat ggaatcaaaa gggcagtggt ttcacatcag     2580

cgacacacat gtgcaagctg tgcctacaac taaagtacta aactcacaag cgtacctcct     2640

attttatgag agaatactgt aataatatca aaagcacttt ttctggaaac acatttatgg     2700

cttttataat ggctgaaata acgataaaaa aagactaatt aaaatcatgt tcacttaaca     2760

ttaaatacat gccagaagaa atcatgttta tttaaatatt gaagggaaaa atacctaaaa     2820

atgtacaaag gttttatatt gtcatagtgg tttttattcc tgctttgttt ctggaaagga     2880

aatcctgaat tacttaagta ctttgtgttt aatatatctg ggtgatggat cacaacacat     2940

caataaactg acttacccta aaa                                             2963


<210> 2549
<211> 2745
<212> DNA
<213> Homo sapiens

<400> 2549
agtggcggga ggctgtgagc tgagcggtgg ggtctgcgta cgcctggagt ccttccccgc       60

tgtgctcagc atggacccta tccggagctt ctgcgggaag ctgcggtctc tggccagcac      120

gctggactgc gagacggccc ggctgcagcg agcgctggac ggagaggaaa gcgactttga      180

agattatcca atgagaattt tatatgacct tcattcagaa gttcagactc taaaggatga      240

tgttaatatt cttcttgata aagcaagatt ggaaaatcaa gaaggcattg atttcataaa      300

ggcaacaaaa gtactaatgg aaaaaaattc aatggatatt atgaaaataa gagagtattt      360

ccagaagtat ggatatagtc cacgtgtcaa gaaaaattca gtacacgagc aagaagccat      420

taactctgac ccagagttgt ctaattgtga aaattttcag aagactgatg tgaaagatga      480

tctgtctgat cctcctgttg caagcagttg tatttctgag aagtctccac gtagtccaca      540

actttcagat tttggacttg agcggtacat cgtatcccaa gttctaccaa accctccaca      600

ggcagtgaac aactataagg aagagcccgt aattgtaacc ccacctacca aacaatcact      660

agtaaaagta ctaaaaactc caaaatgtgc actaaaaatg gatgattttg agtgtgtaac      720

tcctaaatta gaacactttg gtatctctga atatactatg tgtttaaatg aagattacac      780

aatgggactt aaaaatgcga ggaataataa aagtgaggag gccatagata cagaatccag      840

gctcaatgat aatgtttttg ccactcccag ccccatcatc cagcagttgg aaaaaagtga      900

tgccgaatat accaactctc ctttggtacc tacattctgt actcctggtt tgaaaattcc      960

atctacaaag aacagcatag ctttggtatc cacaaattac ccattatcaa aaacaaatag     1020

ttcatcaaat gatttggaag ttgaagatcg tacttcgttg gttttaaatt cagacacatg     1080

ctttgagaat ttaacagatc cctcttcacc tacgatttct tcttatgaga atctgctcag     1140

aacacctaca cctccggaag taactaaaat tccagaagat attctccaga aattccagtg     1200

gatctatcca acacagaaac tgaacaaaat gagatgaaag ccgagctgga ccgattttaa     1260

cattcacatt gccctgcctc tgtccccctt taaacgttga cccattttaa agacaaacat     1320

gaacattaac atcataatat gctttttatg aagtttcaat aaggtttaac cttagtcttg     1380

ttgacatgta gcccagtcat tcactcttta aggattatta gtgtttcatt gatactaaat     1440

tacccagctt aatcaacaga atggtttaag tagtaccagg aagtaggaca agtaatttca     1500

aaaatataaa ggtgtttgct actcagatga ggccgcccct gaccttctgg ccagagagac     1560

attgctgcca gccagctctg ccttcccatc atctcctttc aggaccgtcc cacacctttt     1620

acttgctcag tgctgtctga agatgcagtt gctgtttgca aacaacagga acaccagtta     1680

aactaattag gaaaagaggg agatttccag gcctgggtaa ctatatactg tgaccattgg     1740

aggtagagac aggtctcaac agttggaacc aggaactctg ctgtcaggtt gagagttttg     1800

tttctcttcc agcttttcac tgtgtggggg tcttttctct tatgtcagct ctttctatca     1860

catggcagct gacctctcac gctccactct gcagcttgga cacccagtag accctgaatt     1920

tcactctctc taaaaggttc tgagggctca tcctgggcca ggggccctcc tgtgcactgt     1980

tagctatggc cacgggagcc tccagagctg cctggtagct tcaggttgac ctgcttatca     2040

ggcctacgat ccttctgatt taagtacagc tggaaagtat tatctaatta agttcatgat     2100

agtgcttttg gagaacttgt caaattacag ccaatgagaa aataaggacc tagcatactg     2160

tggagaacca ttaaaaattt gagaagaaac aacaagtatt atgtcaactt acttcaaagg     2220

cgtagttttg ggaatttgat gcagtaaaga ttaccctgtt ttatgattgt tccttgaaag     2280

tcaaatgggg gacctgtcca ttgtgctcta ttaatcttgt cagaaaactg tcaccaaaac     2340

aaaacttgag tttgtccttg ttctaggagt tactgggtag ttgtaagtat tatttttatt     2400

aaatataatg taaaataaaa tgttaagata cttagttttg tttttcaaag taaagctgta     2460

gtcagcctta tgtatgccat tgactctgaa atgtatacca gcctttcact gtgtaccgtg     2520

tgtatataaa tccacagaac cggatgagct gcttagggag ggaatatatt caaagtgtac     2580

caaggaccaa atcctggagt tctcccaact ttagaggatg gaaaggggca gagtaatcta     2640

gcaaaggaga ctgaggccag tgaagtagga agaaagtatt tcaaggagag tgatgattct     2700

gtgaatattg ctgagaattc aaataaaaag aggactgaga actga                     2745


<210> 2550
<211> 1551
<212> DNA
<213> Homo sapiens

<400> 2550
aatcccagac agcgcacggc gggaggctgt cgttgggcgt gcgcagctgc agcggcggtt       60

gaggtcaagt agtagcgttg ggctgcggca gcggaggagc tcaacatgcg tgagtgtatc      120

tctatccacg tggggcaggc aggagtccag atcggcaatg cctgctggga actgtactgc      180

ctggaacatg gaattcagcc cgatggtcag atgccaagtg ataaaaccat tggtggtggg      240

gacgactcct tcaacacgtt cttcagtgag actggagctg gcaagcacgt gcccagagca      300

gtgtttgtgg acctggagcc cactgtggtc gatgaagtgc gcacaggaac ctataggcag      360

ctcttccacc cagagcagct gatcaccggg aaggaagatg cggccaataa ttacgccaga      420

ggccattaca ccatcggcaa ggagatcgtc gacctggtcc tggaccggat ccgcaaactg      480

gcggatctgt gcacgggact gcagggcttc ctcatcttcc acagttttgg gggtggcact      540

ggctctgggt tcgcatctct gctcatggag cggctctcag tggattacgg caagaagtcc      600

aagctagaat ttgccattta cccagccccc caggtctcca cggccgtggt ggagccctac      660

aactccatcc tgaccaccca cacgaccctg gaacattctg actgtgcctt catggtcgac      720

aatgaagcca tctatgacat atgtcggcgc aacctggaca tcgagcgtcc cacgtacacc      780

aacctcaatc gcctgattgg gcagatcgtg tcctccatca cggcctccct gcgatttgac      840

ggggccctga atgtggactt gacggaattc cagaccaacc tagtgccgta cccccgcatc      900

cacttccccc tggccaccta cgccccggtc atctcagccg agaaggccta ccacgagcag      960

ctgtccgtgg ctgagatcac caatgcctgc ttcgagccag ccaatcagat ggtcaagtgt     1020

gaccctcgcc acggcaagta catggcctgc tgcatgttgt acagggggga tgtggtcccg     1080

aaagatgtca acgcggccat cgccaccatc aagaccaagc gcaccatcca gtttgtagat     1140

tggtgcccaa ctggatttaa ggtgggcatt aactaccagc cccccacggt ggtccctggg     1200

ggagacctgg ccaaggtgca gcgggctgtg tgcatgctga gcaacaccac ggccatcgcg     1260

gaggcctggg ctcgcctgga ccataagttc gatctcatgt atgccaagcg ggcctttgtg     1320

cactggtacg tgggagaagg catggaggag ggggagttct ctgaggcccg cgaggacctg     1380

gcagctctgg agaaggatta tgaagaggtg ggcgtggatt ccgtggaagc cgaggctgaa     1440

gaaggtgaag aatactgagg ggagggtgtg gtgggttctc cactccactg ccacccccag     1500

cgtggctgct ttcaagttct ttgcaattaa aggttctgta taaaaccaag a              1551


<210> 2551
<211> 5178
<212> DNA
<213> Homo sapiens

<400> 2551
gcggccgccg tggccctcac agtcggcgtt tcgccgcctg cccgcggtgc ccgcgcacgc       60

cggccgccat cgccttcgcg cctggctggc gggggcgctg tcctcccagg ccgtccgcgc      120

cgctccctgg agctcggcgg agcgcggcag ccagggccgg cggaggcgcg aggagccggg      180

cgccaccgcc gccgccgccg ccgccgccgc gggggccatg accgtggagc agaacgtgct      240

gcagcagagc gcggcgcaga agcaccagca gacgtttttg aatcaactga gagaaattac      300

ggggattaat gacacccaga tactacagca agccttgaag gatagtaatg gaaacttgga      360

attagcagtg gctttcctta ctgcgaagaa tgctaagacc cctcagcagg aggagacaac      420

ttactaccaa acagcacttc ctggcaatga tagatacatc agtgtgggaa gccaagcaga      480

tacaaatgtg attgatctca ctggagatga taaagatgat cttcagagag caattgcctt      540

gagtttggcc gaatcaaaca gggcattcag ggagactgga ataactgatg aggaacaagc      600

cattagcaga gttcttgaag ccagcatagc agagaataaa gcatgtttga agaggacacc      660

tacagaagtt tggagggatt ctcgaaaccc ttatgataga aaaagacagg acaaagctcc      720

cgttgggcta aagaatgttg gcaatacttg ttggtttagt gctgttattc agtcattatt      780

taatcttttg gaatttagaa gattagttct gaattacaag cctccatcaa atgctcaaga      840

tttaccccga aaccaaaagg aacatcggaa tttgcctttt atgcgtgagc tgaggtatct      900

atttgcactt cttgttggta ccaaaaggaa gtatgttgat ccatcaagag cagttgaaat      960

tcttaaggat gctttcaaat caaatgactc acagcagcaa gatgtgagtg agtttacaca     1020

caaattatta gattggttag aagatgcctt ccaaatgaaa gctgaagagg agacggatga     1080

agagaagcca aagaacccca tggtagagtt gttctatggc agattcctgg ctgtgggagt     1140

acttgaaggt aaaaaatttg aaaacactga aatgtttggt cagtacccac ttcaggtcaa     1200

tgggttcaaa gatctgcatg agtgcctaga agctgcaatg attgaaggag aaattgagtc     1260

tttacattca gagaattcag gaaaatcagg ccaagagcat tggtttactg aattaccacc     1320

tgtgttaaca tttgaattgt caagatttga atttaatcag gcattgggaa gaccagaaaa     1380

aattcacaac aaattagaat ttccccaagt tttatatttg gacagataca tgcacagaaa     1440

cagagaaata acaagaatta agagggaaga gatcaagaga ctgaaagatt acctcacggt     1500

attacaacaa aggctagaaa gatatttaag ctatggttcc ggtcccaaac gattcccctt     1560

ggtagatgtt cttcagtatg cattggaatt tgcctcaagt aaacctgttt gcacttctcc     1620

tgttgacgat attgacgcta gttccccacc tagtggttcc ataccatcac agacattacc     1680

aagcacaaca gaacaacagg gagccctatc ttcagaactg ccaagcacat caccttcatc     1740

agttgctgcc atttcatcga gatcagtaat acacaaacca tttactcagt cccggatacc     1800

tccagatttg cccatgcatc cggcaccaag gcacataacg gaggaagaac tttctgtgct     1860

ggaaagttgt ttacatcgct ggaggacaga aatagaaaat gacaccagag atttgcagga     1920

aagcatatcc agaatccatc gaacaattga attaatgtac tctgacaaat ctatgataca     1980

agttccttat cgattacatg ccgttttagt tcacgaaggc caagctaatg ctgggcacta     2040

ctgggcatat atttttgatc atcgtgaaag cagatggatg aagtacaatg atattgctgt     2100

gacaaaatca tcatgggaag agctagtgag ggactctttt ggtggttata gaaatgccag     2160

tgcatactgt ttaatgtaca taaatgataa ggcacagttc ctaatacaag aggagtttaa     2220

taaagaaact gggcagcccc ttgttggtat agaaacatta ccaccggatt tgagagattt     2280

tgttgaggaa gacaaccaac gatttgaaaa agaactagaa gaatgggatg cacaacttgc     2340

ccagaaagct ttgcaggaaa agcttttagc gtctcagaaa ttgagagagt cagagacttc     2400

tgtgacaaca gcacaagcag caggagaccc agaatatcta gagcagccat caagaagtga     2460

tttctcaaag cacttgaaag aagaaactat tcaaataatt accaaggcat cacatgagca     2520

tgaagataaa agtcctgaaa cagttttgca gtcgaaacct gaaaatacta caagccaacc     2580

actttctaat cagcgagttg tagaggtggc gatccctcat gtagggaaat ttatgattga     2640

atcaaaggag ggggggtatg atgacgagat catgatgaca ccgaacatgc aaggtattat     2700

catggcgata ggtaaatcca ggagtgtata tgacaggtgt ggccctgaag cagggttctt     2760

taaggcaatt aagttggaat atgcaaggtt ggttaagttg gcccaagaag acaccccacc     2820

agaaaccgat tatcgtttac atcatgtagt ggtctacttt atccagaacc aggcaccaaa     2880

gaaaattatt gagaaaacat tactagaaca atttggagat agaaatttga gttttgatga     2940

aaggtgtcac aacataatga aagttgctca agccaaactg gaaatgataa aacctgaaga     3000

agtaaacttg gaggaatatg aggagtggca tcaggattat aggaaattca gggaaacaac     3060

tatgtatctc ataattgggc tagaaaattt tcaaagagaa agttatatag attccttgct     3120

gttcctcatc tgtgcttatc agaataacaa agaactcttg tctaaaggct tatacagagg     3180

acatgatgaa gaattgatat cacattatag aagagaatgt ttgctaaaat taaatgagca     3240

agccgcagaa ctcttcgaat ctggagagga tcgagaagta aacaatggtt tgattatcat     3300

gaatgagttt attgtcccat ttttgccatt attactggtg gatgaaatgg aagaaaagga     3360

tatactagct gtagaagata tgagaaatcg atggtgttcc taccttggtc aagaaatgga     3420

accacacctc caagaaaagc tgacagattt tttgccaaaa ctgcttgatt gttctatgga     3480

gattaaaagt ttccatgagc caccgaagtt accttcatat tccacgcatg aactctgtga     3540

gcgatttgcc cgaatcatgt tgtccctcag tcgaactcct gctgatggaa gataaactgc     3600

acactttccc tgaacacact gtataaactc tttttagttc ttaacccttg ccttcctgtc     3660

acagggtttg cttgttgctg ctatagtttt taactttttt ttattttaat aactgcaaaa     3720

gacaaaatga ctatacagac tttagtcaga ctgcagacaa taaagctgaa aatcgcatgg     3780

cgctcagaca ttttaaccgg aactgatgta taatcacaaa tctaattgat tttattatgg     3840

caaaactatg cttttgccac cttcctgttg cagtattact ttgcttttat cttttctttc     3900

tcaacagctt tccattcagt ctggatcctt ccatgactac agccatttaa gtgttcagca     3960

ctgtgtacga tacataatat ttggtagctt gtaaatgaaa taaagaataa agttttattt     4020

atggctacct atgtgtttgt aagcaggtat attgtatatt agtgtattag taatactaga     4080

taaatgaatt ttgtctgggg attaagattg gatagttaat agattaatac aatcttttaa     4140

ttctgctcta atgctagcaa attggaaaat gtttaagtct ttgacactta aatttatcta     4200

tatttttaac aaagttcttg aacttagtat ggcaccggaa cctgttttga attcagtcag     4260

gtttttactc aagtaagtgg ttgatttttt ttaagtcaaa ctacactgaa acttttatcc     4320

ttttcttaga ttaatcttac tttttaaatg tatttacaat atacagcaag gtgattattt     4380

caagagaatc ccaaagtact tgaataaggg ctattgtaaa atttaaaaga aatatttata     4440

tatacacata tatacacata cacacatgta tatatatatt cttcataatg gaggacaatg     4500

ttttgcaata tataaatcat tctatttttg taaattgtat atcactttaa ttgaaaatgt     4560

tctctactaa ttaatactgt gaaacaaaat tgatgttgtt taactagaag ttatgagtat     4620

cttaactgcc tttattcctt ttcaaaaagg aaaaagctgt agaacatttt gtagatgaaa     4680

ctactgttta agattaatga attaatattg tgaatgaaaa tcaaaatcca tactttaaag     4740

gtaatcatgt tactaacaac ctatttttga attcataaaa atttctttat aaatgatgtt     4800

ttgtgaacat agtaaaatag accattatac tatgtgtatg tttgatacag cgtcgccaaa     4860

actagtgttc tttattagtg cctctcacaa aagatcctgg atggaggagt aagatgaaat     4920

attatgctat tatatgatgc tgtttgtaaa ggtattaatg tactagtaag gtgttaatga     4980

caaggaatta gtactattcc tgttgtaaag ttagattttg catattgtat ctatcaaaat     5040

atgtttgggt ttagatttta agttgtctac tgagcagatt tctgcattgg ttttccagtc     5100

ctgttaaaag tttagaaact tcatatgtgt catcacagct tttgtaaaga aagtatcctt     5160

aatattttat gacattct                                                   5178


<210> 2552
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 2552
agtccgccgt ccgccctccg cgcccgcgcc gctagcatga ccgacgcgct gttgcccgcg       60

gccccccagc cgctggagaa ggagaacgac ggctactttc ggaagggctg taatcccctt      120

gcacaaaccg gccggagtaa attgcagaat caaagagctg ctttgaatca gcagatcctg      180

aaagccgtgc ggatgaggac cggagcggaa aaccttctga aagtggccac aaactcaaag      240

gtgcgggagc aagtgcggct ggagctgagc ttcgtcaact cagacctgca gatgctcaag      300

gaagagctgg aggggctgaa catctcggtg ggcgtctatc agaacacaga gattttatcc      360

tggaacatta cagtgaagat ggctatttat atgaagatga aattgcagat cttatggatc      420

tgagacaagc ttgtcggacg cctagccggg atgaggccgg ggtggaactg ctgatgacat      480

acttcatcca gctgggcttt gtcgagagtc gattcttccc gcccacacgg cagatgggac      540

tcctgttcac ctggtatgac tctctcaccg gggttccggt cagccagcag aacctgctgc      600

tggagaaggc cagtgtcctg ttcaacactg gggccctcta cacccagatt gggacccggt      660

gtgatcggca gacgcaggct gggctggaga gtgccataga tgcctttcag agagccgcag      720

gggttttaaa ttacctgaaa gacacattta cccatactcc aagttacgac atgagccctg      780

ccatgctcag cgtgctcgtc aaaatgatgc ttgcacaagc ccaagaaagc gtgtttgaga      840

aaatcagcct tcctgggatc cggaatgaat tcttcatgct ggtgaaggtg gctcaggagg      900

ctgctaaggt gggagaggtc taccaacagc tacacgcagc catgagccag gcgccggtga      960

aagagaacat cccctactcc tgggccagct tagcctgcgt gaaggcccac cactacgcgg     1020

ccctggccca ctacttcact gccatcctcc tcatcgacca ccaggtgaag ccaggcacgg     1080

atctggacca ccaggagaag tgcctgtccc agctctacga ccacatgcca gaggggctga     1140

cacccttggc cacactgaag aatgatcagc agcgccgaca gctggggaag tcccacttgc     1200

gcagagccat ggctcatcac gaggagtcgg tgcgggaggc cagcctctgc aagaagctgc     1260

ggagcattga ggtgctacag aaggtgctgt gtgccgcaca ggaacgctcc cggctcacgt     1320

acgcccagca ccaggaggag gatgacctgc tgaacctgat cgacgccccc agtgttgttg     1380

ctaaaactga gcaagaggtt gacattatat tgccccagtt ctccaagctg acagtcacgg     1440

acttcttcca gaagctgggc cccttatctg tgttttcggc taacaagcgg tggacgcctc     1500

ctcgaagcat ccgcttcact gcagaagaag gggacttggg gttcaccttg agagggaacg     1560

cccccgttca ggttcacttc ctggatcctt actgctctgc ctcggtggca ggagcccggg     1620

aaggagatta tattgtctcc attcagcttg tggattgtaa gtggctgacg ctgagtgagg     1680

ttatgaagct gctgaagagc tttggcgagg acgagatcga gatgaaagtc gtgagcctcc     1740

tggactccac atcatccatg cataataaga gtgccacata ctccgtggga atgcagaaaa     1800

cgtactccat gatctgctta gccattgatg atgacgacaa aactgataaa accaagaaaa     1860

tctccaagaa gctttccttc ctgagttggg gcaccaacaa gaacagacag aagtcagcca     1920

gcaccttgtg cctcccatcg gtcggggctg cacggcctca ggtcaagaag aagctgccct     1980

cccctttcag ccttctcaac tcagacagtt cttggtacta atgtgaggaa acaaacatgt     2040

tcaggccctg aacatttccg gtgctgactc ggccttaaac gtttgtgcca taatggaaaa     2100

tatctatcta tctgttctca aatcctgttt ttctcatagt gtaaactcac atttgatgtg     2160

tttttatgaa ggaaagtaac caagaaacct ctaggaatta gtgaaaaaag aacttttttg     2220

aggtgtgtta ctatactgct gtaagttatt tattatataa agtattgtaa atagaatagt     2280

gttgaagata tgaaatatgg ctatttttaa tggtgacaat tatgactttt agtcactatt     2340

aaattggggt tacctatatc agtacaattt gtagttgt                             2378


<210> 2553
<211> 4309
<212> DNA
<213> Homo sapiens

<400> 2553
aacgtccgcg ggcgcggggt gtgtcgggtg tcgacggcgg cgctttgcgg ccggtcgtgc       60

gggtcgggcg cgggcgggcg cggcggcagt ggcgcgcaca ggtgattgac tggccagctg      120

cctgaaggag cgccaggtcc tccttgctgg caggtggcga agcccattgg ggcggcggtg      180

cagaccgcgg cggcggctgc ggcggtctgg ctcgggaggc gttcctgggg ccaaggccat      240

ggccccgcgg ctgcagctgg agaaggcggc ctggcgctgg gcggagacgg tgcggcccga      300

ggaggtgtcg caggagcaca tcgagaccgc ttaccgcatc tggctggagc cctgcattcg      360

cggcgtgtgc agacgaaact gcaaaggaaa tccgaattgc ttggttggta ttggtgagca      420

tatttggtta ggagaaatag atgaaaatag ttttcataac atcgatgatc ccaactgtga      480

gaggagaaaa aagaactcat ttgtgggcct gactaacctt ggagccactt gttatgtcaa      540

cacatttctt caagtgtggt ttctcaactt ggagcttcgg caggcactct acttatgtcc      600

aagcacttgt agtgactaca tgctgggaga cggcatccaa gaagaaaaag attatgagcc      660

tcaaacaatt tgtgagcatc tccagtactt gtttgccttg ttgcaaaaca gtaataggcg      720

atacattgat ccatcaggat ttgttaaagc cttgggcctg gacactggac aacagcagga      780

tgctcaagaa ttttcaaagc tctttatgtc tctattggaa gatactttgt ctaaacaaaa      840

gaatccagat gtgcgcaata ttgttcaaca gcagttctgt ggagaatatg cctatgtaac      900

tgtttgcaac cagtgtggca gagagtctaa gcttttgtca aaattttatg agctggagtt      960

aaatatccaa ggccacaaac agttaacaga ttgtatctcg gaatttttga aggaagaaaa     1020

attagaagga gacaatcgct atttttgcga gaactgtcaa agcaaacaga atgcaacaag     1080

aaagattcga cttcttagcc ttccttgcac tctgaacttg cagctaatgc gttttgtctt     1140

tgacaggcaa actggacata agaaaaagct gaatacctac attggcttct cagaaatttt     1200

ggatatggag ccttatgtgg aacataaagg tgggtcctac gtgtatgaac tcagcgcagt     1260

cctcatacac agaggagtga gtgcttattc tggccactac atcgcccacg tgaaagatcc     1320

acagtctggt gaatggtata agtttaatga tgaagacata gaaaagatgg aggggaagaa     1380

attacaacta gggattgagg aagatctagc agaaccttct aagtctcaga cacgtaaacc     1440

caagtgtggc aaaggaactc attgctctcg aaatgcatat atgttggttt atagactgca     1500

aactcaagaa aagcccaaca ctactgttca agttccagcc tttcttcaag agctggtaga     1560

tcgggataat tccaaatttg aggagtggtg tattgaaatg gctgagatgc gtaagcaaag     1620

tgtggataaa ggaaaagcaa aacacgaaga ggttaaggag ctgtaccaaa ggttacctgc     1680

tggagctgag ccctatgagt ttgtctctct ggaatggctg caaaagtggt tggatgaatc     1740

aacacctacc aaacctattg ataatcacgc ttgcctgtgt tcccatgaca agcttcaccc     1800

ggataaaata tcaattatga agaggatatc tgaatatgca gctgacattt tctatagtag     1860

atatggagga ggtccaagac taactgtgaa agccctgtgt aaggaatgtg tagtagaacg     1920

ttgtcgcata ttgcgtctga agaaccaact aaatgaagat tataaaactg ttaataatct     1980

gctgaaagca gcagtaaagg gcagcgatgg attttgggtg gggaagtcct ccttgcggag     2040

ttggcgccag ctagctcttg aacagctgga tgagcaagat ggtgatgcag aacaaagcaa     2100

cggaaagatg aacggtagca ccttaaataa agatgaatca aaggaagaaa gaaaagaaga     2160

ggaggaatta aattttaatg aagatattct gtgtccacat ggtgagttat gcatatctga     2220

aaatgaaaga aggcttgttt ctaaagaggc ttggagcaaa ctgcagcagt actttccaaa     2280

ggctcctgag tttccaagtt acaaagagtg ctgttcacag tgcaagattt tagaaagaga     2340

aggggaagaa aatgaagcct tacataagat gattgcaaac gagcaaaaga cttctctccc     2400

aaatttgttc caggataaaa acagaccgtg tctcagtaac tggccagagg atacggatgt     2460

cctctacatc gtgtctcagt tctttgtaga agagtggcgg aaatttgtta gaaagcctac     2520

aagatgcagc cctgtgtcat cagttgggaa cagtgctctt ttgtgtcccc acgggggcct     2580

catgtttaca tttgcttcca tgaccaaaga agattctaaa cttatagctc tcatatggcc     2640

cagtgagtgg caaatgatac aaaagctctt tgttgtggat catgtaatta aaatcacgag     2700

aattgaagtg ggagatgtaa acccttcaga aacacagtat atttctgagc ccaaactctg     2760

tccagaatgc agagaaggct tattgtgtca gcagcagagg gacctgcgtg aatacactca     2820

agccaccatc tatgtccata aagttgtgga taataaaaag gtgatgaagg attcggctcc     2880

ggaactgaat gtgagtagtt ctgaaacaga ggaggacaag gaagaagcta aaccagatgg     2940

agaaaaagat ccagatttta atcaaatcat gcatgcattt tcagttgctc cttttgacca     3000

gaatttgtca attgatggaa agattttaag tgatgactgt gccaccctag gcacccttgg     3060

cgtcattcct gaatctgtca ttttattgaa ggctgatgaa ccaattgcag attatgctgc     3120

aatggatgat gtcatgcaag tttgtatgcc agaagaaggg tttaaaggta ctggtcttct     3180

tggacattaa tctttgaata cttgctgact gctaagaaat gaccagaggg gaagaggagt     3240

ttgacatgtt agggcattaa agcaaaggtg gatttaagaa ttaaaccatt acatgcccct     3300

tccaaaaggc agaaatccat tcaaacgtga ctgtcccaaa tgccttatgt caaataaagc     3360

agattgcact gatggacatc agacttgaag gaaatgtttc caattttata tttaaggggg     3420

gtggtgggtg ggagggggca agtaaagacg gaacaagttt agtagcagta atagtaaatc     3480

atgtttacat atgagattta tagtcgtggg aggggaataa agttctgtta tatttccttg     3540

ctcgagtttc ataccagatg cgttggtcca taaaggattg tatcaagtag atgggacaac     3600

attctgctct gaacgaaaag taattttaga gacataacct gcttaccaat gcctgtcttt     3660

gattcatatt ctactttcaa taaagcatga aagtgaagaa cttgtcctaa gtgtggaaaa     3720

gtgtcttcag atttagactc ttctccatgt cagctgcagc gccacccgcc ttacacctgc     3780

ccggccgtct gtctcttggt attgggtaaa ggagggggca cctgcatgtc tcctgcaatg     3840

agcaaggaat tatgtctcat gttttgactt cagaggcttt ttgctttggt gcatttcaga     3900

aaggatggag aacatttatt atgtgtgaaa gcatcctctt ccggttttgc tgttattcaa     3960

aagtgggaaa tgtacctggc acgtttgaaa ataaaaaatc tgactaccta tcagaagagt     4020

aaatcagact gaagtacatt tggataacac aaggtttcta taaaatttgt tcttcctgtc     4080

ctccatgtca ctgtttcttg gacctcagtt ctctttttga aagcattatt ccaaaatgcc     4140

ctgagagggt ctcttagatc attgtttaaa aaaggaaaaa agtatatgga tgtgctgtcc     4200

atccaactca ggattatcat tcttagcaac acgtaaccga agcaatattc ttaagaatat     4260

tgaaggggtt tttttaattg aacttaagac tggagttttt cctttgaaa                 4309


<210> 2554
<211> 873
<212> DNA
<213> Homo sapiens

<400> 2554
agctcaaccc ccagcacggc tgcatccacc atgtccgtct gctccagcga cctgagctat       60

ggcagccgcg tctgccttcc tggttcctgt gactcttgct ccgactcctg gcaggtggac      120

gactgcccag agagctgctg tgagcccccc tgctgcgccc cggccccctg cctgagcctg      180

gtctgcaccc cagtgagccg tgtatccagc ccctgctgcc gagtgacctg tgagcccagc      240

ccctgccaat caggctgcac cagctcctgc acgccctcgt gctgccagca gtctagctgc      300

cagccggctt gctgcacctc ctccccctgc cagcaggcct gctgcgtgcc cgtctgctgc      360

aagactgtct gctgcaagcc tgtgtgctgt atgcccgtct gctgtgggcc ttcttcttca      420

tgctgccagc agtctagctg ccagccagct tgctgcatct cctccccgtg tcaacagtcc      480

tgctgtgtgc ccgtctgctg caagcccatc tgctgtgtgc ctgtctgctc tggggcctcc      540

tctctgtgct gccagcagtc tagctgccag ccagcttgct gcaccacctc ctgctgcaga      600

ccctcctcct ccgtgtccct cctctgccgc cctgtgtgca gacccgcccg ccgcgtgccc      660

gtcccctcct gctgtgtccc cacctcctcc tgccagccaa gctgcggccg cctggcctcc      720

tgcgggtccc tcctctgccg ccccacatgt tcccgcctgg cctgctgagg cctctgctca      780

ggccagaagt ccagctgctg ccaggcatgt cccccagggc cactgggcac tatgagtccc      840

ccacctctcc cactactggc ccctcggctg ctc                                   873


<210> 2555
<211> 1238
<212> DNA
<213> Homo sapiens

<400> 2555
ctccaccagt tcaaccccag catggccgcg tccaccatgt ccgtctgctc cagcgacctg       60

agctacggca gccgcgtctg ccttcctggt tcctgtgact cttgctccga ctcctggcag      120

gtggacgact gcccagagag ctgctgtgag cccccctgct gcgccccggc cccctgcctg      180

agcctggtct gcaccccagt gagccgtgtg tccagcccct gctgcccagt gacctgtgag      240

cccagcccct gccaatcagg ctgcaccagc tcctgcacgc cctcgtgctg ccagcagtct      300

agctgccagc tggcttgctg tgcctcctcc ccctgccagc aggcctgctg cgtgcccgtc      360

tgctgcaaga ctgtctgctg caagcctgtg tgctgtgtgt ccgtctgctg tggggattct      420

tcatgctgcc agcagtctag ctgccagtca gcttgctgca cctcctcccc ctgccagcag      480

gcctgctgtg tgcccgtctg ctgcaagcct gtctgctctg ggatttcctc ttcgtgctgc      540

cagcagtcta gctgtgtgag ctgtgtgtcc agcccctgct gccaggcggt ctgtgagccc      600

agcccctgcc aatcaggctg caccagctcc tgcacgccct cgtgctgcca gcagtctagc      660

tgccagccaa cttgctgcac ctcctccccc tgccagcagg cctgctgcgt gcccgtctgc      720

tgcgtgcctg tgtgctgtgt gcccacctgc tctgaggatt cctcttcatg ctgccagcag      780

tctagctgcc agccagcttg ctgcacctcc tccccctgcc agcacgcctg ctgtgtgccc      840

gtctgctctg gggcttccac atcatgctgc cagcagtcta gctgccagcc ggcttgctgc      900

accgcctcct gctgcagacc ctcctcctcc gtgtccctcc tctgccaccc tgtgtgcaag      960

tccacctgct gcgtgcccgt cccctcctgt ggtgcctctg cctcctcctg ccagcccagc     1020

tgctgccgca cggcctcctg tgtttccctc ctctgccgcc ccatgtgctc ccgccctgcc     1080

tgctacagcc tctgctctgg ccagaagtcc agctgctgac agccctggat gtgatccgga     1140

gtcccttccc accaggggct gacctcccag ctgccccagc aagctctgcc ctctctggct     1200

ttgacaccct cagaagatgg ggcaggctct ttgtctta                             1238


<210> 2556
<211> 1150
<212> DNA
<213> Homo sapiens

<400> 2556
ccagctcacg tcttccccac cccagcatgg ccgcgtgcac catgtccgtc tgctccagcg       60

cttgctctga ctcctggcga gtggacgact gcccagagag ctgctgtgag cccccctgcg      120

gcaccgcccc ctgcctgacc ctggtctgca ccccagtgag ctgtgtgtcc agcccctgct      180

gccaggcggc ctgtgagccc agcccctgcc aatcaggctg caccagctcc tgcacgccct      240

cgtgctgcca gccggcttgc tgcgcctcct ccccctgcca gcaggcctgc tgcgtgcccg      300

tctgctgcaa gcctgtgtgc tgcctgccca cctgctctaa ggattcctct tcatgctgcc      360

agcagtctag ctgccagcca acttgctgtg cctcttcctc ctgccagcag tcctgctgtg      420

tgcctgtctg ctgcaagccc gtgtgctgtg tgcccacctg ttctgaggat tcctcttcat      480

gctgccagca ttctagctgc cagccgactt gctgcacctc ctccccctgc cagcagtcct      540

gctacgtgcc tgtctgttgc aagcctgtct gcttcaaacc catctgctgt gtgcccgtct      600

gctctggggc ttccacttca tgctgccagc agtctagctg tcagccggct tgctgcacca      660

cctcctgctg cagaccctcc tcctccgtgt ccctcctctg ccgccccata tgcaggcccg      720

cctgctgcgt gcccatctcc tcctgctgtg cccctgcctc ctcctaccag gccagctgct      780

gccgcccggc ctcctgcgtg tccctcctct gccgccccgc gtgctcccgc ctggcctgct      840

gaggcctctg ctcaggccag gagtccagtt gctgatgtgc acatccccca gggccaactg      900

gtcctgactc gggttaggag gttgcccccg cttgggacgg ggcccccatg tgctgaggtg      960

acccccccct ccatactccc aggaatctcc atcctcgaag ctccccagct cctgcctccc     1020

agcaggggcc cacctgcctg ttgggtcccc tgtcctccct cccagcttct ctgccccagg     1080

tcacttggcc tcgacttgaa cctgtcagca cctcctcctg ctccccaata aactcccctt     1140

ggtcgcctga                                                            1150


<210> 2557
<211> 1382
<212> DNA
<213> Homo sapiens

<400> 2557
agctcaaccc ccagcacagc agcatccacc atgtccgtct gctccagcga cctgagctac       60

agcagccgcg tctgccttcc tggttcctgt gactcttgct ccgactcctg gcaggtggac      120

gactgcccag agagctgctg cgagcccccc tgctgcgccc ccagctgctg cgccccggcc      180

ccctgcctga gcctggtctg caccccagtg agccgtgtgt ccagcccctg ctgcccagtg      240

acctgcgagc ccagcccctg ccaatcaggc tgcaccagct cctgcacgcc ctcgtgctgc      300

cagcagtcta gctgccagct ggcttgctgt gcctcctccc cctgccagca ggcctgctgc      360

gtgcccgtct gctgcaagac tgtctgctgc aagcctgtgt gctgtgtgcc cgtctgctgt      420

ggggattctt catgctgcca gcagtctagc tgccagtcag cttgctgcac ctcctccccc      480

tgccagcagg cctgctgtgt gcccatctgc tgcaagcctg tctgctctgg gatttcctct      540

tcgtgctgcc agcagtctag ctgtgtgagc tgtgtgtcca gcccctgctg ccaggcggtc      600

tgtgagccca gcccctgcca atcaggctgc atcagctcct gcacgccctc gtgctgccag      660

cagtctagct gccagccggc ttgctgcacc tcctcctcct gccagcaggc ctgctgcgtg      720

cccgtctgct gcaagactgt ctgctgcaag cctgtgtgct ctgaggattc ctcttcatgc      780

tgccagcagt ctagctgcca gccggcttgc tgcacctcct ctccctgcca gcaggcttgc      840

tgtgtgcctg tctgctgcaa gcctgtgtgc tgcaagcctg tcggctctgt gcccatctgc      900

tctggggctt cctctctgtg ctgccagcag tctagctgcc agccagcttg ctgcacctcc      960

tcccaaagcc agcagggctg ctgcgtgccc gtctgctgca agcctgtgag ctgtgtgcct     1020

gtttgctctg gggcttcctc ttcatgctgc cagcaatcta gctgccagcc agcttgctgc     1080

accacctcct gctgcagacc ctcctcctcc gtgtccctcc tctgccgccc cgtgtgcagg     1140

cccgcctgct gcgtgcccgt cccttcctgc tgtgctccca cctcctcctg ccaacccagc     1200

tgctgccgcc cagcctcctg cgtgtccctc ctctgacgcc ccgtgtgctc ccgcccagcc     1260

tgctgaggcc tccgctcagg tcagaagccc agctgctgat ggacacgccc cccagtgcca     1320

gccaggctca ggtcccacct gaaagctgat agtcgcgtcc tgaattgctc ctgcactttg     1380

ac                                                                    1382


<210> 2558
<211> 1215
<212> DNA
<213> Homo sapiens

<400> 2558
tcactcactc acacctcccg cagctcacct cctccccacc ccagcatggc cgcgtccacc       60

atgtccgtct gctccagcgc ttgctccgac tcctggcagg tggatgcctg cccagagagc      120

tgctgtgagc cccactgctg cgccctcagc tgctgcgccc cggccccctg cctgaccctg      180

gtctgcaccc cagtgagccg tgtgtccagc ccctgctgcc aggcagcctg tgagcccagc      240

ccctgccaat caggctgcac cagctcctgc acgccctcgt gctgccagca gtctagctgc      300

cagccggctt gctgcacctc ctccccctgc cagcaggcct gctgcgtgcc cgtctgctgc      360

aagcctgtgt gctgcctgcc cacctgctct aaggattcct cttcatgctg ccagcagtct      420

agctgccagc caacttgctg tgcctcttcc tccagccagc agtcctgctg tgtgcctgtt      480

tgctgcaagc ctgtgtgcta tgtgcccacc tgctctgagg attcctcttc atgctgccag      540

cagtctagct gccatccagc ttgctgcacc tcctccccct gccagcaggc ctgctgcgtg      600

cccgtccgtt gcaagcctgt ctgctgcaag cccatctgct gtgtgcccgt ctgctctggg      660

gcttccactt catgctgcca gcagtctagc tgccagccgg cttgctgcac cacctcctgc      720

tgcagaccct cctcctccgt gtccctcctc tgccgccctg tatgccggcc cgcctgctgt      780

atgcctgtct cctcctgctg tgcccctgcc tcctcctgcc aggccagctg ctgccgcccg      840

gcctcctgcg tgtccctcct ctgccgcccc gcgtgctccc gcccggcctg ctgaggcctc      900

tgctcaggcc aggagtccag ctgctgatgg gcacccgccc tgggccagct gggctcagtt      960

cctgacctgg gttaggtggc ttcccccacc taggacgggt ccccgtgtct cccctgtgct     1020

gaggtgaccc cccctccttg ctcccaggag cctccatcct tgcagctccc cagctcttgc     1080

cttccagcag gtgcccacct gcctgctagg tcccctgtcc tccctcccag cttctctgct     1140

ctgggtcact tggcctcgac ttgaacctct cagcacctcc tcctgctccc caataaactc     1200

tccttggtca cctga                                                      1215


<210> 2559
<211> 891
<212> DNA
<213> Homo sapiens

<400> 2559
atggcttcca gtccgctgcc agggcccaac gacatcctgc tggcgtcgcc gtcgagcgcc       60

ttccagcccg acacgctgag ccagccgcgg ccagggcacg ccaacctcaa acccaaccag      120

gtgggccagg tgatcctcta cggcattccc atcgtgtcgt tggtgatcga cgggcaagag      180

cgcctgtgcc tggcgcagat ctccaacact ctgctcaaga acttcagcta caacgagatc      240

cacaaccgtc gcgtggcact gggcatcacg tgtgtgcagt gcacgccggt gcaactggag      300

atcctgcggc gtgccggggc catgcccatc tcatcgcgcc gctgcggcat gatcaccaaa      360

cgcgaggccg agcgtctgtg caagtcgttc ctgggcgaaa acaggccgcc caagctgcca      420

gacaatttcg ccttcgacgt gtcacacgag tgcgcctggg gctgccgcgg cagcttcatt      480

cccgcgcgct acaacagctc gcgcgccaag tgcatcaaat gcagctactg caacatgtac      540

ttctcgccca acaagttcat tttccactcc caccgcacgc ccgacgccaa gtacactcag      600

ccagacgcag ccaacttcaa ctcgtggcgc cgtcatctca agctcaccga caagagtccc      660

caggacgagc tggtcttcgc ctgggaggac gtcaaggcca tgttcaacgg cggcagccgc      720

aagcgcgcac tgccccagcc gggcgcgcac cccgcctgcc acccgctcag ctctataaga      780

acaaggagca tagctttttc atcacagact ctgatgcttc tggaggagat ttttggagag      840

aaagatcagg aggattatat gcgaataaat gaggacaaca tttggttatg a               891


<210> 2560
<211> 6196
<212> DNA
<213> Homo sapiens

<400> 2560
gctctgctcg ttgagtgaag aaaatccacc ggcatcgcct gagccccgct accgagaagg       60

gcgccgcttc ctccggggag ggggataaag atcccccgcc gccggcccat gaggatattg      120

ccgtgaaagg cacagcgact gcagcaggaa ccggacccgg caccggagcg gcggcggcgg      180

cggcagcagc ggtaccgcct cctcacccgg cggcggcagc agcggcggcg gcggcggcgg      240

cggcggcggc ggcggcagcg gtcccccctc ctcacccgaa catcagggcc ctccagactc      300

aggcgcccca acaaattcct agaggacctg tgcaacaacc tcttgaggat cgaatcttca      360

ctcccgctgt ctcagcagtc tacagcacgg taacacaagt ggcaagacag ccgggaaccc      420

ctaccccatc cccttattca gcacatgaaa taaacaaggg gcatccaaat cttgcggcaa      480

cgcccccggg acatgcatcg tcccctggac tctctcaaac cccttatccc tctggacaga      540

atgcaggtcc aaccacgctg gtataccctc aaacccctca gacaatgaat tcacaacctc      600

aaacccgttc tccggtaatt ttctcccctt cccagttttt ccagaggcct caaatacagc      660

ctcctagagc taccatcccg aacagcagtc cttccattcg tcctggtgca cagacaccca      720

ctgcagtgta ccaggctaat cagcacatca tgatggttaa ccatctgccc atgccgtacc      780

cagtgcccca ggggcctcag tactgtatac cacagtaccg tcatagtggc cctccttatg      840

ttgggccccc ccaacaatat ccagttcaac caccggggcc aggtcctttt tatcctggac      900

caggacctgg ggacttcccc aatgcttatg gaacgccttt ttacccaagt cagccggtgt      960

atcagtcagc acctatcata gtgcctacgc agcaacagcc gcctccagcc aagagagaga     1020

aaaaaactat aagaattcgg gatccaaacc agggaggtaa agacataaca gaggagatta     1080

tgtctggagg tggcagcaga aatcctactc cacccatagg aagacccacg tccacaccta     1140

ctcctcctca gctgcccagc caggtccccg agcacagccc tgtggtttat gggactgtgg     1200

agagcgctca tcttgctgcc agcacccctg tcactgcagc tagcgaccag aagcaagagg     1260

agaagccaaa accagatcca gtgttaaagt ctccttcccc agtccttagg ctagtcctca     1320

gtggagagaa gaaagaacaa gaaggccaga catctgaaac tactgcaata gtatccatag     1380

cagagcttcc tctgcctcca tcacctacca ctgtttcttc tgttgctcga agtacaattg     1440

cagcccccac ctcttctgct cttagtagcc aaccaatatt caccactgct atagatgaca     1500

gatgtgaact ctcatcccca agagaagaca caattcctat acccagcctc acatcttgca     1560

cagaaacatc agacccttta ccaacaaatg aaaatgatga tgatatatgc aagaaaccct     1620

gtagtgtagc acctaatgat attccactgg tttctagtac taacctaatt aatgaaataa     1680

atggagttag cgaaaaatta tcagccacgg agagcattgt ggaaatagta aaacaggaag     1740

tattgccatt gactcttgaa ttggagattc tcgaaaatcc cccagaagaa atgaaactgg     1800

agtgtatccc agctcccatc accccttcca cagttccttc ctttcctcca actcctccaa     1860

ctcctccagc ttctcctcct cacactccag tcattgttcc tgctgctgcc actactgtta     1920

gttctccgag tgctgccatc acagtccaga gagtcctaga ggaggacgag agcataagaa     1980

cttgccttag tgaagatgca aaagagattc agaacaaaat agaggtagaa gcagatgggc     2040

aaacagaaga gattttggat tctcaaaact taaattcaag aaggagccct gtcccagctc     2100

aaatagctat aactgtacca aagacatgga agaaaccaaa agatcggacc cgaaccactg     2160

aagagatgtt agaggcagaa ttggagctta aagctgaaga ggagctttcc attgacaaag     2220

tacttgaatc tgaacaagat aaaatgagcc aggggtttca tcctgaaaga gacccctctg     2280

acctaaaaaa agtgaaagct gtggaagaaa atggagaaga agctgagcca gtacgtaatg     2340

gtgctgagag tgtttctgag ggtgaaggaa tagatgctaa ttcaggctcc acagatagtt     2400

ctggtgatgg ggttacattt ccatttaaac cagaatcctg gaagcctact gatactgaag     2460

gtaagaagca gtatgacagg gagtttctgc tggacttcca gttcatgcct gcctgtatac     2520

aaaaaccaga gggcctgcct cctatcagtg atgtggttct tgacaagatc aaccaaccca     2580

aattgccaat gcgaactctg gatcctcgaa ttttgcctcg aggaccagac tttacaccag     2640

cctttgctga ttttggaagg cagacacctg gtggaagagg cgtacctttg ttgaatgttg     2700

ggtcacgaag atctcaacct ggccaaagaa gagaacccag aaagatcatc acagtttctg     2760

taaaagaaga tgtacacctg aaaaaggcag aaaatgcctg gaagccaagc caaaaacgag     2820

acagccaagc cgatgatccc gaaaacatta aaacccagga gctttttaga aaagttcgaa     2880

gtatcttaaa taaattgaca ccacagatgt tcaatcaact gatgaagcaa gtgtcaggac     2940

ttactgttga cacagaggag cggctgaaag gagttattga cctggtcttt gagaaggcta     3000

ttgatgaacc cagtttctct gtggcttacg caaacatgtg tcgatgtcta gtaacgctga     3060

aagtacccat ggcagacaag cctggtaaca cagtgaattt ccggaagctg ctactgaacc     3120

gttgccagaa ggagtttgaa aaagataaag cagatgatga tgtctttgag aagaagcaga     3180

aagaacttga ggctgccagt gctccagagg agaggacaag gcttcatgat gaactggaag     3240

aagccaagga caaagcccgg cggagatcca ttggcaacat caagtttatt ggagaactct     3300

ttaaactcaa aatgctgact gaagccatca tgcatgactg tgtggtgaag ctgctaaaga     3360

accatgatga agaatccctg gagtgcctgt gtcgcctgct caccaccatt ggcaaagact     3420

tggactttga aaaagcaaag ccacgtatgg accagtactt taatcagatg gagaaaattg     3480

tgaaagaaag aaaaacctca tctaggattc ggttcatgct tcaagatgtt atagacctaa     3540

ggctgtgcaa ttgggtatct cgaagagcag atcaagggcc taaaactatc gaacagattc     3600

acaaagaggc taaaatagaa gaacaagaag agcaaaggaa ggtccagcaa ctcatgacca     3660

aagagaagag aagaccaggt gtccagagag tggacgaagg tgggtggaac actgtacaag     3720

gggccaagaa cagtcgggta ctggacccct caaaattcct aaaaatcact aagcctacaa     3780

ttgatgaaaa aattcagctg gtacctaaag cacagctagg cagctgggga aaaggcagca     3840

gtggtggagc aaaggcaagt gagactgatg ccttacggtc aagtgcttcc agtttaaaca     3900

gattctctgc cctgcaacct ccagcaccct cagggtccac gccatccacg cctgtagagt     3960

ttgattcccg aaggacctta actagtcgtg gaagtatggg cagggagaag aatgacaagc     4020

cccttccatc tgcaacagct cggccaaata ctttcatgag gggtggcagc agtaaagacc     4080

tgctagacaa tcagtctcaa gaagagcagc ggagagagat gctggagacc gtgaagcagc     4140

tcacaggagg tgtggatgtg gagaggaaca gcactgaggc tgagcgaaat aaaacaaggg     4200

agtcagcaaa accagaaatt tcagcaatgt cagctcatga caaggctgca ttatcagaag     4260

aggaactgga gaggaagtcg aaatctatca ttgatgaatt tctacacatt aatgatttta     4320

aggaagccat gcagtgtgtg gaagagctga atgcccaggg cctactacat gtttttgtga     4380

gagtgggagt ggagtccacc ctggaaagga gccagatcac cagggatcac atgggccaat     4440

tactctatca gctggtacag tcagaaaaac tcagcaaaca ggactttttc aaaggttttt     4500

cagaaacttt ggaattggca gatgacatgg ccattgatat tccccatatt tggttgtacc     4560

ttgctgaact ggtgaccccc atgttaaaag aaggtggaat ctccatgaga gaacttacca     4620

tagaatttag caaaccttta cttcctgttg gaagagctgg ggtcttgcta tctgaaatat     4680

tgcacctact atgcaaacaa atgagccata agaaagtggg agccttatgg agggaggctg     4740

acctcagctg gaaggacttt ttaccagaag gagaagatgt acataatttt cttttggagc     4800

agaagttgga cttcatagag tctgacagtc cctgttcctc tgaagcactt tcaaagaaag     4860

aactgtctgc cgaagagctg tataagcgac tcgagaaact cattattgag gacaaagcga     4920

atgatgaaca gatctttgac tgggtagagg ctaatctaga cgaaatccag atgagttcac     4980

ctacattcct tagagcttta atgactgctg tttgtaaagc agctattata gccgactctt     5040

ctaccttcag agtggacact gctgttatca agcagagagt gccgatctta ctcaagtacc     5100

tagactcaga tacagagaag gaactgcaag cactttatgc actacaagca tcgatagtaa     5160

aacttgatca acctgccaat ttgctgcgga tgttttttga ttgtctatat gacgaggagg     5220

tgatctccga ggatgccttc tacaaatggg agagcagcaa ggaccctgca gagcagaatg     5280

ggaagggcgt ggctctgaaa tctgtcacgg cattcttcac gtggctgcgg gaagcagaag     5340

aggagtctga ggataactaa aacttcaaat acacaaaatg aaacaaaaga aacaatttaa     5400

gtattttttt aaaaagtttc acgtcttcgc caatcacagt gcagcaaggc caattctcgc     5460

agaaaccccc acgtgtgcac gagtgggaga ggggaaagag aaaaaaaggt gatcatggag     5520

gaaaaaggta ctggataaaa gtaaacttca aaccttaggg cgggagcact aaaaccaaaa     5580

tacatgtatt atttatagaa aatattttct gttttaatct tttcttttta aacaaggact     5640

catacttaaa aaaatgttta gcaaaaaaaa aaaaagttga gaacttttaa tttattttaa     5700

ggactgcaaa tgccagtgta attttttaat ttgcagtttc tgtaaacaac ttgtataata     5760

gaaaagcaga gaaataaatt tccctcccct tcaagatgca cctcatgttt gttttaaggt     5820

atagcattta gtccagattt gagaaagttt ggggtgaaca aggtaagaaa gatttttttt     5880

tttttggcat caaatctttc tgcctgcctc tcagcttgct tcagaaaatt taaaaaatca     5940

caatagtaat caaaacatac ataacattga aacagaagga aatgctgtgg accacagaac     6000

tccaagaatt gtttaaaaaa aaaaaagtgc taccctgaga aaagtactct taatactctt     6060

gaaatcttta gagcaacttt aaggcttgta aatacataga acaaatattt aaaaaaacaa     6120

aaagaaattg actcagtact atttcttttc actttgaaaa tataaagaac aaaataaaga     6180

caaacattgc aagttt                                                     6196


<210> 2561
<211> 6175
<212> DNA
<213> Homo sapiens

<400> 2561
ctgctcgttg agtgaagaaa atccaccggc atcgcctgag ccccgctacc gagaagggcg       60

ccgcttcctc cggggagggg gataaagatc ccccgccgcc ggcccatgag gatattgccg      120

tgaaaggcac agcgactgca gcaggaaccg gacccggcac cggagcggcg gcggcggcgg      180

cagcagcggt accgcctcct cacccggcgg cggcagcagc ggcggcggcg gcggcggcgg      240

cggcggcggc ggcagcggtc ccccctcctc acccgaacat cagggccctc cagactcagg      300

cgccccaaca aattcctaga ggacctgtgc aacaacctct tgaggatcga atcttcactc      360

ccgctgtctc agcagtctac agcacggtaa cacaagtggc aagacagccg ggaaccccta      420

ccccatcccc ttattcagca catgaaataa acaaggggca tccaaatctt gcggcaacgc      480

ccccgggaca tgcatcgtcc cctggactct ctcaaacccc ttatccctct ggacagaatg      540

caggtccaac cacgctggta taccctcaaa cccctcagac aatgaattca caacctcaaa      600

cccgttctcc gtttttccag aggcctcaaa tacagcctcc tagagctacc atcccgaaca      660

gcagtccttc cattcgtcct ggtgcacaga cacccactgc agtgtaccag gctaatcagc      720

acatcatgat ggttaaccat ctgcccatgc cgtacccagt gccccagggg cctcagtact      780

gtataccaca gtaccgtcat agtggccctc cttatgttgg gcccccccaa caatatccag      840

ttcaaccacc ggggccaggt cctttttatc ctggaccagg acctggggac ttccccaatg      900

cttatggaac gcctttttac ccaagtcagc cggtgtatca gtcagcacct atcatagtgc      960

ctacgcagca acagccgcct ccagccaaga gagagaaaaa aactataaga attcgggatc     1020

caaaccaggg aggtaaagac ataacagagg agattatgtc tggaggtggc agcagaaatc     1080

ctactccacc cataggaaga cccacgtcca cacctactcc tcctcagcag ctgcccagcc     1140

aggtccccga gcacagccct gtggtttatg ggactgtgga gagcgctcat cttgctgcca     1200

gcacccctgt cactgcagct agcgaccaga agcaagagga gaagccaaaa ccagatccag     1260

tgttaaagtc tccttcccca gtccttaggc tagtcctcag tggagagaag aaagaacaag     1320

aaggccagac atctgaaact actgcaatag tatccatagc agagcttcct ctgcctccat     1380

cacctaccac tgtttcttct gttgctcgaa gtacaattgc agcccccacc tcttctgctc     1440

ttagtagcca accaatattc accactgcta tagatgacag atgtgaactc tcatccccaa     1500

gagaagacac aattcctata cccagcctca catcttgcac agaaacatca gaccctttac     1560

caacaaatga aaatgatgat gatatatgca agaaaccctg tagtgtagca cctaatgata     1620

ttccactggt ttctagtact aacctaatta atgaaataaa tggagttagc gaaaaattat     1680

cagccacgga gagcattgtg gaaatagtaa aacaggaagt attgccattg actcttgaat     1740

tggagattct cgaaaatccc ccagaagaaa tgaaactgga gtgtatccca gctcccatca     1800

ccccttccac agttccttcc tttcctccaa ctcctccaac tcctccagct tctcctcctc     1860

acactccagt cattgttcct gctgctgcca ctactgttag ttctccgagt gctgccatca     1920

cagtccagag agtcctagag gaggacgaga gcataagaac ttgccttagt gaagatgcaa     1980

aagagattca gaacaaaata gaggtagaag cagatgggca aacagaagag attttggatt     2040

ctcaaaactt aaattcaaga aggagccctg tcccagctca aatagctata actgtaccaa     2100

agacatggaa gaaaccaaaa gatcggaccc gaaccactga agagatgtta gaggcagaat     2160

tggagcttaa agctgaagag gagctttcca ttgacaaagt acttgaatct gaacaagata     2220

aaatgagcca ggggtttcat cctgaaagag acccctctga cctaaaaaaa gtgaaagctg     2280

tggaagaaaa tggagaagaa gctgagccag tacgtaatgg tgctgagagt gtttctgagg     2340

gtgaaggaat agatgctaat tcaggctcca cagatagttc tggtgatggg gttacatttc     2400

catttaaacc agaatcctgg aagcctactg atactgaagg taagaagcag tatgacaggg     2460

agtttctgct ggacttccag ttcatgcctg cctgtataca aaaaccagag ggcctgcctc     2520

ctatcagtga tgtggttctt gacaagatca accaacccaa attgccaatg cgaactctgg     2580

atcctcgaat tttgcctcga ggaccagact ttacaccagc ctttgctgat tttggaaggc     2640

agacacctgg tggaagaggc gtacctttgt tgaatgttgg gtcacgaaga tctcaacctg     2700

gccaaagaag agaacccaga aagatcatca cagtttctgt aaaagaagat gtacacctga     2760

aaaaggcaga aaatgcctgg aagccaagcc aaaaacgaga cagccaagcc gatgatcccg     2820

aaaacattaa aacccaggag ctttttagaa aagttcgaag tatcttaaat aaattgacac     2880

cacagatgtt caatcaactg atgaagcaag tgtcaggact tactgttgac acagaggagc     2940

ggctgaaagg agttattgac ctggtctttg agaaggctat tgatgaaccc agtttctctg     3000

tggcttacgc aaacatgtgt cgatgtctag taacgctgaa agtacccatg gcagacaagc     3060

ctggtaacac agtgaatttc cggaagctgc tactgaaccg ttgccagaag gagtttgaaa     3120

aagataaagc agatgatgat gtctttgaga agaagcagaa agaacttgag gctgccagtg     3180

ctccagagga gaggacaagg cttcatgatg aactggaaga agccaaggac aaagcccggc     3240

ggagatccat tggcaacatc aagtttattg gagaactctt taaactcaaa atgctgactg     3300

aagccatcat gcatgactgt gtggtgaagc tgctaaagaa ccatgatgaa gaatccctgg     3360

agtgcctgtg tcgcctgctc accaccattg gcaaagactt ggactttgaa aaagcaaagc     3420

cacgtatgga ccagtacttt aatcagatgg agaaaattgt gaaagaaaga aaaacctcat     3480

ctaggattcg gttcatgctt caagatgtta tagacctaag gctgtgcaat tgggtatctc     3540

gaagagcaga tcaagggcct aaaactatcg aacagattca caaagaggct aaaatagaag     3600

aacaagaaga gcaaaggaag gtccagcaac tcatgaccaa agagaagaga agaccaggtg     3660

tccagagagt ggacgaaggt gggtggaaca ctgtacaagg ggccaagaac agtcgggtac     3720

tggacccctc aaaattccta aaaatcacta agcctacaat tgatgaaaaa attcagctgg     3780

tacctaaagc acagctaggc agctggggaa aaggcagcag tggtggagca aaggcaagtg     3840

agactgatgc cttacggtca agtgcttcca gtttaaacag attctctgcc ctgcaacctc     3900

cagcaccctc agggtccacg ccatccacgc ctgtagagtt tgattcccga aggaccttaa     3960

ctagtcgtgg aagtatgggc agggagaaga atgacaagcc ccttccatct gcaacagctc     4020

ggccaaatac tttcatgagg ggtggcagca gtaaagacct gctagacaat cagtctcaag     4080

aagagcagcg gagagagatg ctggagaccg tgaagcagct cacaggaggt gtggatgtgg     4140

agaggaacag cactgaggct gagcgaaata aaacaaggga gtcagcaaaa ccagaaattt     4200

cagcaatgtc agctcatgac aaggctgcat tatcagaaga ggaactggag aggaagtcga     4260

aatctatcat tgatgaattt ctacacatta atgattttaa ggaagccatg cagtgtgtgg     4320

aagagctgaa tgcccagggc ctactacatg tttttgtgag agtgggagtg gagtccaccc     4380

tggaaaggag ccagatcacc agggatcaca tgggccaatt actctatcag ctggtacagt     4440

cagaaaaact cagcaaacag gactttttca aaggtttttc agaaactttg gaattggcag     4500

atgacatggc cattgatatt ccccatattt ggttgtacct tgctgaactg gtgaccccca     4560

tgttaaaaga aggtggaatc tccatgagag aacttaccat agaatttagc aaacctttac     4620

ttcctgttgg aagagctggg gtcttgctat ctgaaatatt gcacctacta tgcaaacaaa     4680

tgagccataa gaaagtggga gccttatgga gggaggctga cctcagctgg aaggactttt     4740

taccagaagg agaagatgta cataattttc ttttggagca gaagttggac ttcatagagt     4800

ctgacagtcc ctgttcctct gaagcacttt caaagaaaga actgtctgcc gaagagctgt     4860

ataagcgact cgagaaactc attattgagg acaaagcgaa tgatgaacag atctttgact     4920

gggtagaggc taatctagac gaaatccaga tgagttcacc tacattcctt agagctttaa     4980

tgactgctgt ttgtaaagca gctattatag ccgactcttc taccttcaga gtggacactg     5040

ctgttatcaa gcagagagtg ccgatcttac tcaagtacct agactcagat acagagaagg     5100

aactgcaagc actttatgca ctacaagcat cgatagtaaa acttgatcaa cctgccaatt     5160

tgctgcggat gttttttgat tgtctatatg acgaggaggt gatctccgag gatgccttct     5220

acaaatggga gagcagcaag gaccctgcag agcagaatgg gaagggcgtg gctctgaaat     5280

ctgtcacggc attcttcacg tggctgcggg aagcagaaga ggagtctgag gataactaaa     5340

acttcaaata cacaaaatga aacaaaagaa acaatttaag tattttttta aaaagtttca     5400

cgtcttcgcc aatcacagtg cagcaaggcc aattctcgca gaaaccccca cgtgtgcacg     5460

agtgggagag gggaaagaga aaaaaaggtg atcatggagg aaaaaggtac tggataaaag     5520

taaacttcaa accttagggc gggagcacta aaaccaaaat acatgtatta tttatagaaa     5580

atattttctg ttttaatctt ttctttttaa acaaggactc atacttaaaa aaatgtttag     5640

caaaaaaaaa aaaagttgag aacttttaat ttattttaag gactgcaaat gccagtgtaa     5700

ttttttaatt tgcagtttct gtaaacaact tgtataatag aaaagcagag aaataaattt     5760

ccctcccctt caagatgcac ctcatgtttg ttttaaggta tagcatttag tccagatttg     5820

agaaagtttg gggtgaacaa ggtaagaaag attttttttt ttttggcatc aaatctttct     5880

gcctgcctct cagcttgctt cagaaaattt aaaaaatcac aatagtaatc aaaacataca     5940

taacattgaa acagaaggaa atgctgtgga ccacagaact ccaagaattg tttaaaaaaa     6000

aaaaagtgct accctgagaa aagtactctt aatactcttg aaatctttag agcaacttta     6060

aggcttgtaa atacatagaa caaatattta aaaaaacaaa aagaaattga ctcagtacta     6120

tttcttttca ctttgaaaat ataaagaaca aaataaagac aaacattgca agttt          6175


<210> 2562
<211> 3731
<212> DNA
<213> Homo sapiens

<400> 2562
cttggcccgg gctgctggga gtccccggcg gggcgggggt cagctctggt cccgttggtc       60

ctgggcgcgg cgccatggcc tccgaggcgg tgaaggttgt cgtgcgctgc cgtcccatga      120

accagcggga gcgagagctg cgctgccagc ccgtggtgac tgtggactgc gcgcgcgccc      180

agtgctgcat ccagaacccg ggcgccgccg acgagccgcc caagcagttc accttcgacg      240

gcgcctacca cgtggaccac gtcaccgagc agatctacaa cgagatcgcc tatccgctgg      300

tggagggcgt cactgagggc tacaatggca ccatctttgc ctacggccag acaggcagcg      360

ggaagtcctt caccatgcag ggcctgccgg atccgccctc ccagagaggc atcatcccca      420

gggccttcga gcacgtgttc gagagcgtcc agtgtgcaga gaacactaag ttcctggtcc      480

gggcctccta cctggagatc tacaatgaag atgtccggga cctccttggg gctgacacca      540

agcagaagct ggagctgaag gagcacccag agaagggcgt gtacgtgaag gggctgtcca      600

tgcacacggt gcacagcgtg gcccagtgtg agcacatcat ggagactggc tggaagaacc      660

gttcggtcgg ctacacgctg atgaacaagg attcctcacg ctcgcactcc atcttcacca      720

tcagcatcga gatgtctgcc gtggatgagc ggggcaagga ccacctccgg gcgggcaagc      780

tgaacctggt ggacctggcg ggcagcgagc ggcagtccaa gaccggggcc acgggcgagc      840

ggctcaagga ggccaccaag atcaacctgt cgctctcggc actgggcaat gtcatctcgg      900

cgctggtgga cgggcgctgt aagcacgtcc cctaccgtga ctcgaagctg acgcggctgc      960

tgcaggactc actgggcggc aacaccaaga cgctcatggt ggcctgcctg tcgcctgcgg     1020

acaacaacta cgatgagaca ctcagcacgc tgcgctacgc caaccgggcc aagaacatca     1080

ggaacaagcc gcgcatcaat gaggacccca aggatgcgct gcttcgcgag taccaggagg     1140

agatcaagaa gctcaaggcc atcctgacac agcagatgag ccccagcagc ctgtcagccc     1200

tgctgtccag gcaggtgccc ccagaccctg tgcaggtgga ggagaagctg ttgccccaac     1260

ctgtgatcca gcatgacgtg gaggccgaga agcagctgat ccgggaggag tatgaagagc     1320

gcctggcccg gctgaaagcc gactataagg ccgagcagga gtctcgggcc aggctggagg     1380

aagacatcac tgccatgcgc aactcatatg acgtcaggct gtccacgctg gaggagaacc     1440

tgcggaagga gacagaggct gtcctgcagg tgggagtcct ctacaaggct gaggtcatgt     1500

ccagggctga gtttgccagc agcgctgagt acccgcctgc ttttcagtat gagacagtgg     1560

tgaaacccaa ggtcttctcc acgactgaca ctctgcccag tgacgatgtc tccaagactc     1620

aggtttcctc caggtttgcg gagctgccca aggtggaacc ctccaaatct gagatttctc     1680

tgggctccag tgagtcatcc tcgctcgaag aaacctctgt gtccgaggct ttccctgggc     1740

ctgaggagcc ctccaacgtg gaggtctcca tgcccactga ggagtccagg agcagatact     1800

tcctggatga gtgcctcggg caggaggccg ctgggcacct gctgggggaa cagaactacc     1860

tcccgcaaga ggagccgcag gaggtgcccc tgcaggggtt actaggcctg caggacccgt     1920

ttgccgaggt ggaagccaag ctggccagac tctcctccac cgtggccagg acagatgcac     1980

cccaggcaga cgtccccaag gtccctgtgc aggtccctgc gccgacagac ctgctggagc     2040

ccagtgatgc caggcccgaa gccgaggcgg ctgatgactt cccgcccagg cctgaggtag     2100

atctggcctc ggaagtggcc ttagaggtgg tgcggacagc agagcctggc gtgtggttgg     2160

aggctcaggc cccggtggcc ctggtggctc agcctgagcc cctgccggcc acagctggtg     2220

tgaagaggga gagcgtgggc atggaggtgg cagtgctgac tgatgacccg ctgcccgttg     2280

tggaccagca gcaggtgctg gcccgtctgc agctgttgga gcagcaggtt gtgggtggag     2340

agcaggccaa gaacaaggac ctgaaggaga agcacaagcg gcgcaagcgc tacgcagacg     2400

agcgcaggaa gcagctggtg gctgccctgc agaactcgga tgaggacagc ggggactggg     2460

tgctgcttaa cgtctacgac tccatccagg aggaagtgcg ggccaagagc aagctgctgg     2520

agaagatgca gaggaagctt cgggcagcag aggtggagat caaagatctg cagtccgagt     2580

ttcagctgga gaagatcgat tacttggcca ccatccgccg gcaggagcgt gactccatgc     2640

tcttgcagca gctcctggag caggtgcagc ccctgattcg cagggactgt aactacagca     2700

acctggagaa gattctgcgt gagtcctgct gggacgaaga taacggcttc tggaagatcc     2760

cacatcccgt catcacaaaa accagcctcc cagtagtttc aactgggcca cagaacaaac     2820

cagcccgcaa aacctctgca gcagacaatg gcgagccgaa catggaggac gaccgctaca     2880

ggctcatgct cagtcggagc aacagtgaaa acattgccag caactacttc cgatctaagc     2940

gggccagcca gatcctcagc acagacgcca ggaagagcct cacacatcac aactcgccac     3000

caggcctcag ctgcccactc agcaacaact ctgccatccc acccacccag gcccctgaaa     3060

tgccccagcc ccggcccttc cgcctcgagt ccctcgacat ccctttcacc aaggccaagc     3120

gtaagaaaag caaaagcaac tttggcagtg agcctctgtg agcacagctg cttgccattg     3180

cctgccttat aggcatgtag agactgccag gccctcccag ggcagcccca accaggtctc     3240

ctcccacctg ccacacagcg ctccggggcc tgagggctcc ctcagccctg ggaagacaca     3300

ttcccttccc tgttccccag agagcccacc tccgccctgg gcaggagccc ctcggaggct     3360

gtatagtcct ccttagagag gcctgctcca gctgttcata ccacatcagt gtttccgtct     3420

gctcacctgc cacagagccc acacccatgc ccaccagtgt tggtctttgc ctcaaagcct     3480

gagacctgct tcacggcctt caccagccct gatggagagg gcagcagctg ccacgtggag     3540

gaagctcaat atcagctggg aaggaactgt gcctctgtct gactggcccc acttcctaag     3600

cactgccctg ccccatgggg tggcacaggg gtcccacagc aggtcttcct gcactgccca     3660

cccctggctg gtctgtggcc caaggaaggc cactccacat taagctgccc aataaactgc     3720

ttttaagata a                                                          3731


<210> 2563
<211> 1544
<212> DNA
<213> Homo sapiens

<400> 2563
gtgcttatga gataaacgac agggtaactg tccacattgg tcccagttta tgagggagaa       60

gagatcataa tctacaaaaa tttgcaaggt gaccagggga aaagagtacg gcgcctcatc      120

tcccagagat cttccttgga gaccctggaa gatattgagg agaacgcccc tctccggaga      180

tgtcgaactc tctcaggttc acccagacca aagaatttta agaagattca ttttatcaag      240

aacatgcggc aacacgatac caggaatggc agaatagtcc ttatcagtgg cagaagatcc      300

ttctgtagta tattttcagt gctgccgtat cgcgacagta cccaagtcgg ggacttgaag      360

ttggacggag gaagacaatc aactggtgca gtgagtttga aagagatcat tggtctggaa      420

ggtgtggagc tgggtgctga tgggaagact gtttcctata cccaatttct gttacccaca      480

aatgcctttg gagcccggag aaataccata gactccacct cctctttctc ccagttccgt      540

aacctgagcc accgcagcct ctccataggc cgggcaagcg gcacccaggg gagcctcgac      600

acaggtagtg acctgggaga ctttatggac tatgacccaa atctcttgga tgacccccag      660

tggccttgtg gcaaacacaa acgcgttctg atcttccctt cctacatgac aacagtgatt      720

gactacgtga agccctcgga tctcaagaag gacatgaacg agaccttcaa ggagaagttt      780

cctcacatta agctgacact cagcaaaatt aggagtctga aacgagagat gcggaagctt      840

gcgcaggagg actgtggcct tgaggagccc acggtggcca tggccttcgt ctactttgaa      900

aagctcgccc tcaaggggaa actcaacaaa cagaaccgga agctgtgtgc tggggcatgt      960

gtgctgttag cagccaaaat tggaagtgac ctcaaaaaac acgaagtcaa gcatttaatt     1020

gacaaactgg aagagaagtt ccggctgaac aggcgagaac tgattgcctt tgaattcccg     1080

gtgttagtgg ccttggaatt cgccctccac ttgcccgagc acgaagtcat gccccactac     1140

agacggctgg tccagagttc ctagcactgg ccccgaggac agccaagggc catttcttct     1200

cagcttggtg gagcagcact tacttactac tggaaatgaa aaaaagtaga actcagaata     1260

ccagactttt cttcctctcg acatagtttg gggagaagca gtactagaaa ctttccaagg     1320

agtcttgggt gtgtagccaa gaggagccat gagctatgga ctcctcaagc acgggaagag     1380

gaggtgtgtg ctgagaacag agaggccctg ccctctgtcc actagcgaga atccctagct     1440

gccccagccc agtctttctc cccggcattc acaaactttg caagcgtggt ccagggcctt     1500

ctccagatct gttccaactt ggagtgtgaa gggcttgagc atac                      1544


<210> 2564
<211> 4246
<212> DNA
<213> Homo sapiens

<400> 2564
agggctccac agtcgttccg ccacctccca gtcgggttgc ggcggaggcc gttcctggct       60

ttgtagctcg ctcaagatgg cggcgcagcc accccgcggg atacgcctca gcgcgctttg      120

cccgaagttt ttacatacaa attctactag tcacacctgg ccattcagtg cagttgctga      180

attaatagat aatgcttatg atcctgatgt gaacgctaaa caaatatgga ttgacaaaac      240

agtgataaat gaccatatat gcttgacatt caccgacaat gggaatggta tgacttctga      300

taaattacat aaaatgctaa gctttggctt cagtgacaaa gtcaccatga atggtcatgt      360

cccagttgga ttatatggga atggcttcaa gtcgggttct atgcgtctgg gtaaagacgc      420

aatcgttttt accaaaaatg gagaaagcat gagcgtgggc cttttgtctc agacctactt      480

ggaagtcata aaagcggagc atgttgttgt tccaatagtg gcattcaaca agcaccgaca      540

gatgattaat ttagcagaat caaaagccag ccttgctgca attctggaac attctctgtt      600

ttccacggaa cagaagttac tggcagaact tgatgctatt ataggcaaga aggggacgag      660

gatcatcatt tggaatctta gaagctacaa aaatgcaaca gagttcgatt ttgaaaagga      720

taaatatgat atcagaattc ccgaggattt agatgagata acagggaaga aggggtacaa      780

gaagcaggaa aggatggacc agattgcccc tgagagtgac tattccctga gggcttattg      840

cagtatatta tatctaaagc caagaatgca gatcatccta cgtggacaga aagtgaagac      900

acagctggtt tcgaagagtc ttgcctacat cgaacgtgat gtttatcgac caaaattttt      960

atctaaaaca gtgagaatta cctttggatt caactgcaga aataaagatc attatgggat     1020

aatgatgtat cacagaaata gactcatcaa agcttatgaa aaagttggat gtcagttaag     1080

ggcaaacaac atgggtgttg gagtggttgg aattatagag tgtaatttcc ttaagccaac     1140

tcataataaa caagatttcg actatactaa tgagtacaga cttacaataa cagcactagg     1200

agaaaagctg aatgattact ggaatgaaat gaaagtgaag aaaaatacag aatatcctct     1260

aaatttgcca gttgaagata tacagaagcg tcctgatcag acatgggttc agtgtgatgc     1320

ctgtctaaag tggcggaaat tacctgatgg gatggatcaa cttcctgaaa aatggtattg     1380

ctccaataac cctgacccac agttcagaaa ttgtgaggtt ccagaagaac ctgaagatga     1440

ggatttggta catcccactt atgaaaaaac ctacaaaaag accaacaagg aaaaattcag     1500

gatcagacaa ccggaaatga tccctcggat taatgctgaa ctgttgtttc ggccaactgc     1560

tctttcaact ccaagctttt cttctcctaa ggaaagtgtt ccaagaagac atctttcaga     1620

aggaacaaat tcttatgcga caagacttct aaataatcat caagttccac ctcagtctga     1680

acctgagagc aacagcttga aacggagact ttctactcgt tcctcaattt tgaatgcaaa     1740

gaatcggaga ttgagtagtc agtttgaaaa ttcagtttat aaaggtgatg atgatgatga     1800

agatgtcatc atcttagaag aaaacagtac ccccaaacct gcagtagatc atgatattga     1860

catgaaatca gaacagagtc acgttgagca aggtggtgtt caggttgagt ttgtgggtga     1920

cagtgaacct tgtggccaga ctggttcaac aagcacctca tcatcccgat gcgaccaggg     1980

aaatactgca gctacccaga ctgaagtacc aagtttagtt gttaaaaaag aagaaactgt     2040

tgaagacgag atagacgtaa gaaatgatgc agtgattctg ccctcctgtg tagaagctga     2100

agcaaagata catgaaaccc aggaaaccac cgataaatct gcagatgatg caggctgcca     2160

attacaagaa ctgagaaacc agctactcct tgtcactgag gaaaaagaga attataaaag     2220

acagtgtcat atgtttactg atcaaatcaa agtgttacaa cagaggatac tagaaatgaa     2280

tgacaagtat gttaagaaag aaacttgcca tcagtccact gaaaccgatg ctgtattttt     2340

acttgaaagt attaatggca aatctgaaag tccagaccat atggtatctc agtatcagca     2400

agctttggaa gaaatagaaa ggctgaaaaa acaatgtagt gctttgcaac atgtaaaggc     2460

tgaatgcagc cagtgttcca ataatgagag taaaagtgaa atggatgaga tggctgtgca     2520

gcttgacgat gtgtttagac aactggacaa atgcagtatt gagagggacc agtataaaag     2580

tgaggttgaa ttgctggaaa tggaaaagtc acaaatccgt tcacagtgtg aagaactcaa     2640

aactgaagta gaacagttaa aatctacaaa tcaacagacg gcaacagatg tttcaacatc     2700

aagtaacatt gaggagtctg taaatcatat ggatggagaa agcctcaaac tccgatctct     2760

tcgagttaac gtaggacaac tgctggctat gattgtgcct gatcttgatc ttcagcaagt     2820

gaattacgat gttgatgtag ttgatgagat tttaggacaa gttgttgaac aaatgagtga     2880

aatcagtagt acttaaagta tatgttatgt aagataaaat atttgctcaa ttcttttggt     2940

tgtacagctt tcaaaatata attaattttg ttttatagat atgataggca acagactgaa     3000

aaccataatc tttactgtat tctatgcatt caaatgtggt cacaaatatt gtggacacat     3060

tatcttatgt tttgaaatac ctgtgaattg ttggcattga gcagctgaag ctaactcatg     3120

actctgtttt gaatgtaaat atttgtaatt aagcctgcac atattttttt attgccctag     3180

agtactcaag tgtttttcac caagagcttt tcaggttgcc cctaagcttt gtgcaatttt     3240

ttctggttcc ccaaagtgta tttttctcta agtcgagggc tatgccataa tacaaatgga     3300

aatgttacct ttgattttct tataaaggag tttaaatagg atttttaaat aatgtagtaa     3360

cactcctgat acaactctgg ttataagtga attgagcatt aatgtttctt ttgtataaat     3420

tcctgtcctg aaatatttta ttcatgaaaa taaggtaagc aaaaaccaac tccattttgc     3480

caggattttg ttgtgctgag attgccaatc acggttaaac acaaagtgtt tttatagaat     3540

gaagaaacag tctttaacag aaaaaaggta ttgaaatatt aaatggccac caagtttact     3600

ttgaagccca tttttggctg tttagtcagc atgaagtggg catgataatt ttttaatatt     3660

tctttttgtg aaatttcctg tacagccttt tgtaggatta ctacaggtta atgtgagttg     3720

aggaagacag tctttctcaa acaatactac atacctttta ttatattaca aacctaagtg     3780

ttttatatcc tagagtcaag gaacaaattt ccttaggatt atagtattac atgccataaa     3840

atactatgct ttattggtcc catgttttgt gcaattttaa agagatggct ttctattaag     3900

tataaactat gtatatataa gaaccatatt ttccacaact aaaatgtgca ttattttttc     3960

caaagtttta tcattgctat ttatttttac ctttgttttt gaacattcaa tccgttcatt     4020

ttgtatgtat gcttaatacg tgtcggtcat atacagtatt gaatttttac tgtatagtaa     4080

ttctggaaag agcaaataaa tgaagattgt ttttatttgc ctgataaagt aattgaaagt     4140

gtatttttgg tatgaagctg gttttctgtc acaattgtaa tttcccaaat tttaaaatat     4200

cttataataa aataaaaata tatgatggct aactgttcaa atgcta                    4246


<210> 2565
<211> 3390
<212> DNA
<213> Homo sapiens

<400> 2565
ctggcggttc tacctccgag ggttcgcccg cccttggttt tccttacacc ttagcctttg       60

gctcctttga ccactcgaag ccccacagcg tgttccagcg gacttcacca gcagacccag      120

aagtggtggg tgaaacactg cctctgttcc tccttgagcc tgtcgggagc tgctgcctgc      180

caccaccatg tctgctgcaa atcctgagac tccaaactca accatctcca gagaggccag      240

cacccagtct tcatcagctg cagctagcca aggctgggtg ttaccagaag gcaaaatcgt      300

gccaaacact gtttttgttg gtggaattga tgctaggatg gatgaaactg agattggaag      360

ctgctttggt agatacggtt cagtgaaaga agtgaagata atcacgaatc gaactggtgt      420

gtccaaaggc tatggatttg tttcgtttgt taatgacgtg gatgtccaga agatagtagg      480

atcacagata catttccatg gtaaaaagct gaagctgggc cctgcaatca ggaaacaaaa      540

gttatgtgct cgtcatgtgc agccacgtcc tttggtagtt aatcctcctc ctccaccaca      600

gtttcagaac gtctggcgga atccaaacac tgaaacctac ctgcagcccc aaatcacgcc      660

gaatcctgta actcagcacg ttcaggctta ctctgcttat ccacattcac caggtcaggt      720

catcactgga tgtcagttgc ttgtatataa ttatcaggaa tatcctactt atcccgattc      780

agcatttcag gtcaccactg gatatcagtt gcctgtatat aattatcagc catttcctgc      840

ttatccaaga tcaccatttc aggtcactgc tggatatcag ttgcctgtat ataattatca      900

ggcatttcct gcttatccaa attcaccatt tcaagtcgcc actggatatc agttccctgt      960

atacaattat cagccatttc ctgcttatcc aagttcacca tttcaggtca ctgctggata     1020

tcagttgcct gtatataatt atcaggcatt tcctgcttat ccaaattcac catttcaagt     1080

cgccactgga tatcagttcc ctgtatacaa ttatcaggca tttcctgctt atccaaattc     1140

accagttcag gtcaccactg gatatcagtt gcctgtatac aattatcagg catttcctgc     1200

ttatccaaat tcaccatttc aagtcgccac tggatatcag ttccctgtat acaattatca     1260

ggcatttcct gcttatccaa attcaccagt tcaggtcacc actggatatc agttgcctgt     1320

atacaattat caggcatttc ctgcttatcc aaattcagca gttcaggtca ccactggata     1380

tcagttccat gtatacaatt accagatgcc accgcagtgc cctgttgggg agcaaaggag     1440

aaatctgtgg accgaagcat acaaatggtg gtatcttgtc tgtttaatcc agagaagaga     1500

ctgataaatt ccgttgttac tcaagatgac tgcttcaagg gtaaaagagt gcatcgcttt     1560

agaagaagtt tggcagtatt taaatctgtt ggatcctctc agctatctag tttcatggga     1620

agttgctggt tttgaatatt aagctaaaag ttttccacta ttacagaaat tctgaatttt     1680

ggtaaatcac actgaaactt tctgtataac ttgtattatt agactctcta gttttatctt     1740

aacactgaaa ctgttcttca ttagatgttt atttagaacc tggttctgtg tttaatatat     1800

agtttaaagt aacaaataat cgagactgaa agaatgttaa gatttatctg caaggatttt     1860

taaaaaattg aaacttgcat tttaagtgtt taaaagcaaa tactgacttt caaaaaagtt     1920

tttaaaacct gatttgaaag ctaacaattt tgatagtctg aacacaagca tttcacttct     1980

ccaagaagta cctgtgaaca gtacaatatt tcagtattga gctttgcatt tatgatttat     2040

ctagaaattt acctcaaaag cagaattttt aaaactgcat ttttaatcag tggaactcaa     2100

tgtatagtta gctttattga agtcttatcc aaacccagta aaacagattc taagcaaaca     2160

gtccaatcag tgagtcataa tgtttattca aagtatttta tcttttatct agaatccaca     2220

tatgtatgtc caatttgatt gggatagtag ttaggataac taaaattctg ggcctaattt     2280

tttaaagaat ccaagacaaa ctaaacttta ctgggtatat aaccttctca atgagttacc     2340

attctttttt ataaaaaaaa ttgttccttg aaatgctaaa cttaatggct gtatgtgaaa     2400

tttgcaaaat actggtatta aagaacgctg cagctttttt atgtcactca aaggttaatc     2460

ggagtatctg aaaggaattg tttttataaa aacattgaag tattagttac ttgctataaa     2520

tagattttta tttttgtttt ttagcctgtt atatttcctt ctgtaaaata aaatatgtcc     2580

agaagaggca tgttgtttct agattaggta gtgtcctcat tttatattgt gaccacacag     2640

ctagagcacc agagcccttt tgctatactc acagtcttgt tttcccagcc tcttttacta     2700

gtctttcagg aggtttgctc ttagaactgg tgatgtaaag aatggaagta gctgtatgag     2760

cagttcaaag gccaagccgt ggaatggtag caatgggata taataccttt ctaagggaaa     2820

catttgtatc agtatcattt gatctgccat ggacatgtgt ttaaagtggc tttctggccc     2880

ttctttcaat ggcttcttcc ctaaaacgtg gagactctaa gttaatgtcg ttactatggg     2940

ccatattact aatgcccact ggggtctatg atttctcaaa attttcattc ggaatccgaa     3000

ggatacagtc tttaaacttt agaattccca agaaggcttt attacacctc agaaattgaa     3060

agcaccatga ctttgtccat taaaaaatta tccatagttt ttttagtgct tttaacattc     3120

cgacatacat cattctgtga ttaaatctcc agatttctgt aaatgatacc tacattctaa     3180

agagttaatt ctaattattc cgatatgacc ttaaggaaaa gtaaaggaat aaatttttgt     3240

ctttgttgaa gtatttaata gagtaaggta aagaagatat taagtccctt tcaaaatgga     3300

aaattaattc taaactgaga aaaatgttcc tactacctat tgctgatact gtctttgcat     3360

aaatgaataa aaataaactt tttttcttca                                      3390


<210> 2566
<211> 5847
<212> DNA
<213> Homo sapiens

<400> 2566
ggcattatgc aattatatta ctaaggctgc tacctgccca tgcccctctc ctcctcctgg       60

tttggaacta ccctccccat ctgctgctat atttatctgc cttcttggcc ataaaaggct      120

ggttgtgtgg cctgacattc gactgcctga ccacatgcat tatttttgaa ctggccccca      180

gggtcctgtc tttagccctg cctcttaaca ttgtcttgga ttcaacctag gtggagtctt      240

cattctctca tccagctcct cggcctcatc ggaacatttc caccaccatt actcctttgg      300

aaactggtgg cccggttcct tcaaggggca caggatgtct ttgccttttt atcagaggtg      360

ccaccagcac tatgatctca gctaccgcaa caaggacgtg cgcagcaccg tgagtcacta      420

ccagcgggag aagaaacgct ccgccgtcta cacccagggc tccacggcct acagcagccg      480

ctcctccgcc gcgcaccgcc gggagtccga ggccttccgt cgggcgtccg cctcctcctc      540

ccagcagcag gcctcgcagc acgccctgag ctctgaagtc agtcggaagg cagcctcagc      600

ctacgattat ggctcctccc atggacttac agattccagt ctgctgttag atgattattc      660

atccaagttg agccccaaac caaagagagc caagcacagc ctactgtctg gagaagagaa      720

agaaaatttg cccagtgact acatggtacc cattttctca ggacgtcaaa agcatgtcag      780

tggaattact gatacggaag aagaaagaat taaagaagct gctgcttata tagcccagag      840

gaatcttctt gctagtgagg aaggaatcac aacatctaaa cagtccacgg catccaagca      900

gaccacggca tctaagcagt ccacggcatc caagcagtcc acagcatcca agcagtccac      960

ggcatccagg cagtccacgg catccaggca gtctgtggtt tccaaacagg ccacatccgc     1020

tcttcaacag gaagaaactt ctgaaaagaa gtcaaggaaa gttgtgattc gagaaaaggc     1080

agaacgcctg tccctgagga aaacattaga agaaaccgag acatatcatg ccaagctgaa     1140

tgaagaccat cttctccatg ctcctgagtt tatcattaaa cctcgctccc acacggtttg     1200

ggagaaggag aatgtaaaat tgcattgctc catagcaggc tggccagaac ctcgtgtcac     1260

gtggtataaa aaccaggtgc caataaatgt ccatgcaaac cctggaaagt atattattga     1320

gagtcgatat gggatgcaca ctctggagat taatggatgt gattttgaag atacagctca     1380

gtaccgggcc tcggcgatga atgttaaagg agagctttcg gcatatgctt cagttgtggt     1440

aaaaaggtat aagggagagt ttgatgagac tcgcttccac gctggggctt ccaccatgcc     1500

cctcagcttt ggtgtgaccc catatggtta tgcatcccgg tttgagatcc actttgatga     1560

caaatttgat gtgtcttttg ggagagaggg agagacaatg agtctaggct gtcgtgttgt     1620

catcactcct gaaattaaac atttccagcc agagatccag tggtacagaa acggagtacc     1680

tctttctcca tcaaaatggg tgcaaacact ttggagtgga gagcgggcaa cgctgacatt     1740

ttcccatctc aacaaagaag atgaaggcct ctatacaatc cgtgtacgga tgggagaata     1800

ttatgaacaa tatagtgctt atgtctttgt tcgagatgct gatgcagaga ttgaaggagc     1860

cccagctgct cccttggatg tgaagtgctt ggaggccaac aaagattata tcatcatctc     1920

ctggaaacag ccagctgtcg atggagggag tcctattctc ggatatttta ttgataagtg     1980

tgaggtgggc acagatagct ggtcgcagtg caatgacaca cctgtgaagt ttgctcgttt     2040

tcctgtcact ggattgatcg aaggtcgttc ctatatcttc cgagttcgag ctgtgaataa     2100

aatgggaata ggtttcccat ctcgagtttc cgagcccgtg gctgctctgg atccggctga     2160

gaaagctaga cttaaaagtc gcccctcagc accctggact ggacagatca ttgttactga     2220

agaggaacct tcagagggta ttgtgcctgg ccccccgaca gacctctctg tcactgaggc     2280

cacccggagc tatgtggtgc tcagctggaa gccccctggc cagcgtggtc atgagggcat     2340

tatgtacttt gtggaaaagt gtgaggcagg aacagaaaac tggcagcgag tgaacacgga     2400

gctccctgtg aagtctcccc gctttgctct gtttgacttg gccgagggga aatcctactg     2460

tttccgtgtc cgctgttcta attctgcagg agttggtgag ccctcagagg caacggaggt     2520

gactgtggta ggggacaaac ttgatatccc caaggctcct ggcaaaatca tcccaagcag     2580

aaacacagac acctcagtgg tagtttcgtg ggaggagtcc aaagatgcca aagagctggt     2640

cgggtactac atagaggcga gcgttgctgg ctctggcaag tgggagccct gtaacaacaa     2700

ccccgtgaag ggctcacgat tcacttgtca tggattagtg actggtcaga gttatatttt     2760

ccgggtcaga gcagtcaatg cagctggact tagtgaatat tcccaggatt cagaagctat     2820

tgaagtcaaa gctgctattg ggggaggagt gtctccagat gtgtgtcccg cactgagcga     2880

tgagcctggt ggactaaccg cctccagggg gcgcgtgcat gaagcctccc cgccaacctt     2940

ccagaaagat gctttgcttg gcagcaaacc taacaaacct tcactaccca gtagctctca     3000

aaacctgggc caaacagaag tgagtaaagt aagtgaaaca gttcaggaag agcttacccc     3060

gccaccacag aaagcggctc ctcaggggaa aagtaagtct gaccccctga aaaagaagac     3120

agacagagca ccaccatctc caccctgtga tatcacctgt cttgaaagtt ttcgtgactc     3180

aatggttctt ggatggaagc aaccagataa gattggaggg gcagaaatta ctggctatta     3240

tgtgaactat cgcgaggtca ttgatggggt accaggaaaa tggagagaag ccaatgtcaa     3300

ggctgtcagt gaggaggcat acaagattag caacttgaag gaaaacatgg tgtatcagtt     3360

ccaagtggca gccatgaaca tggctgggct gggcgcgccc tccgcagtaa gcgaatgctt     3420

caaatgtgaa gagtggacca tcgccgtccc aggaccaccg cacagtctca agtgtagtga     3480

agtcaggaaa gactcactgg ttctccagtg gaagccgcca gtccactccg ggcggactcc     3540

ggtcactggt tacttcgtgg acttgaagga ggccaaggcc aaagaagacc agtggcgagg     3600

gctcaatgag gcggctatta aaaacgtata cctgaaggtt cgaggcctca aggagggcgt     3660

cagctacgtg ttccgtgttc gagccataaa ccaggcggga gttgggaagc catctgacct     3720

tgctggccct gttgtggcag agacccgtcc aggaaccaaa gaggttgttg taaatgtgga     3780

tgatgatgga gtcatttcat tgaacttcga gtgtgataag atgactccaa agtccgagtt     3840

ctcctggtcc aaagattatg tatccactga ggactctcca cgattggaag tcgaaagcaa     3900

gggcaacaag acgaaaatga ccttcaaaga ccttgggatg gatgacttgg gtatttactc     3960

ttgcgatgta acagacactg atggaatagc atcaagctac ttaatagatg aggaagaatt     4020

gaaacgttta cttgctctca gccatgaaca caagttccca actgtcccag ttaaatcaga     4080

gttggcagtt gaaattttgg agaaaggcca ggtccggttt tggatgcagg ctgagaaact     4140

gtctggcaat gccaaagtca actacatatt taacgagaag gaaatttttg aaggcccgaa     4200

atataaaatg catattgacc gaaacactgg catcatcgaa atgttcatgg aaaagctaca     4260

ggatgaggat gagggaacgt acactttcca gcttcaagat ggaaaagcaa ctaaccattc     4320

tactgttgtt ctcgttggag atgttttcaa aaagctccag aaagaagctg aattccagcg     4380

gcaagaatgg atcaggaaac aaggtcctca ctttgttgag tatttgagct gggaagtgac     4440

tggtgaatgt aatgtactat tgaaatgcaa ggtggcaaat attaagaagg agactcatat     4500

tgtgtggtac aaagatgaga gggagatatc agtggatgaa aagcatgact ttaaggatgg     4560

tatatgtacc ctgcttataa cagagttttc caagaaagat gctgggattt atgaagttat     4620

cctgaaagat gaccgaggaa aagataagag cagactgaag cttgtggatg aagcctttaa     4680

ggaactgatg atggaagtat gcaaaaaaat agctttgtct gctacagacc tgaaaatcca     4740

gagcacagcc gagggcatcc aactgtactc ttttgtaact tactatgtgg aggatttgaa     4800

agttaactgg tcccacaatg ggtccgccat taggtactca gacagagtta agaccggggt     4860

cactggagag cagatctggc tacaaatcaa cgagcccacc ccgaatgaca aagggaagta     4920

tgtcatggag ctctttgatg gcaaaactgg acatcagaag acagtggatc tctctggaca     4980

agcatacgat gaggcctatg ctgaattcca gaggttgaaa aagagccttt tatttcagaa     5040

agatcgtgcc cgggtgttgg gaggtctccc agacgtggtc accatccagg aggggaaggc     5100

ccttaatctc acttgcaacg tgtggggaga cccgcctccg gaggtgtcgt ggttgaagaa     5160

cgagaaggcc ctggcctcag acgaccactg caacctcaag ttcgaggctg ggaggaccgc     5220

gtacttcacc atcaacggcg tgagcaccgc tgactcgggc aaatacgggc tggttgtgaa     5280

gaacaagtat ggctcggaga ccagcgactt caccgtcagc gtgttcatcc cagaggagga     5340

ggcgaggatg gccgccttgg agtccctgaa aggtggcaag aaggccaagt gaccggaggt     5400

gcgaggagag ccagccggcc tgtgtgactt gggtgtgaat ggtttgggtt aaggatgaga     5460

cgtcttcatg ctttctcctc cctattattt tctggcttga ggggaaaata atgtcaggtc     5520

tttcactcat ataaaaaagc accaactaat gacactttaa ttgtttttct ttatctacaa     5580

aattatgtgt taagaaaata ccattcatag catgaagatt aggaaacagt tttaaggaga     5640

agacttgaat gaagttggag ggacattgaa tgatggtcag agggcagacg aatgtgtcgt     5700

ggggcgaatt gggatttgct gcagctgtga agccatggcc gtgtctcgtg tgttgttaca     5760

gaggtgatgt gcttttcgac gggcgcctcg tggcttggaa cctcctctgt atgaataaac     5820

agttttcacg tctgtcctct tccccga                                         5847


<210> 2567
<211> 9884
<212> DNA
<213> Homo sapiens

<400> 2567
agaatgcagc gcatggcgcg tcattgaaga gagaccatga tggcggcggc gctggggccc       60

ccagaagtga tcgctcagct ggagaacgcg gctaaagttc tgatggcacc accttccatg      120

gtcaataatg aacaacgcca gcatgcagag cacatattct tatcatttag gaaatcaaaa      180

tcaccatttg cagtttgcaa gcatattttg gaaactagta aagtggacta tgtcctcttt      240

caagctgcca cagccataat ggaagcagtt gtccgagagt ggattctctt ggaaaaaggt      300

agcatcgagt ctctgcgaac attcctttta acctatgtct tacaaaggcc caaccttcaa      360

aagtatgttc gggaacagat tctactagca gtagcagtaa ttgtaaaaag aggatcatta      420

gataaatcaa ttgactgcaa aagcattttt catgaagtca gccagttgat tagtagtggc      480

aatcccactg tgcaaactct ggcctgttct attctgactg cgctattgag tgaattttca      540

agttcaagta aaactagcaa cattggattg agcatggaat tccatggtaa ctgcaaaaga      600

gtttttcagg aagaagacct tcgtcagatc ttcatgttaa ctgttgaagt tctgcaggag      660

ttcagcaggc gggaaaacct caatgctcag atgtcttcag tatttcagcg ttaccttgca      720

ctcgccaatc aagtcttgag ctggaacttt cttcctccaa aactgggcag acattatata      780

gctatgtttg aatcctcgca aaatgtgctg ttgaagccaa cagagtcctg gcgggagact      840

cttctggaca gcagagttat ggagcttttc ttcacagtac atcgaaaaat cagagaagat      900

tcagatatgg cacaagattc tctgcagtgc cttgcccagt tagcttctct tcatggaccc      960

atcttcccag atgaaggatc acaagttgat tatctagcac acttcattga gggattactg     1020

aatactatca atggaattga aatagaagat tctgaagctg tggggatctc cagcattatc     1080

agcaacctga taaccgtgtt cccacgaaat gttttaactg ccattccaag tgaacttttc     1140

tcctcctttg ttaactgcct cacacacctc acttgttctt ttgggcgaag tgctgcattg     1200

gaagaagtgc ttgataaaga tgacatggta tacatggaag catatgataa attgttggag     1260

tcctggttaa ctttggttca agatgacaaa catttccata aaggcttttt tacccaacat     1320

gcagttcaag ttttcaattc ctatattcag tgccacctag ctgctccaga tggcacaaga     1380

aatttgactg ccaatggtgt ggcctctcgt gaggaggaag aaataagtga acttcaagag     1440

gatgatcgag accagttttc tgatcaactg gccagtgtag gaatgctagg aagaattgct     1500

gcagaacact gtatacctct tctgacaagt ttattagaag aaagagtaac aagactccat     1560

ggtcagttac aacgacatca gcaacagtta cttgcttcac cgggttcaag cactgttgac     1620

aacaaaatgc ttgatgatct ctatgaagat attcactggc ttattttagt tacaggctac     1680

ctcttagctg atgatactca gggagagact ccgctaatac ctccagaaat aatggaatat     1740

tccattaagc attcatctga agttgacatt aatacaacac ttcaaatttt gggatctcca     1800

ggagaaaagg cttcttccat cccagggtac aacagaacag attctgtgat taggctgttg     1860

tctgccattc tcagagtttc agaagttgaa tctcgagcaa taagagcaga tctcactcat     1920

ctactaagtc cccagatggg caaagatatt gtttggtttt taaaacgctg ggcaaagact     1980

tatctcctgg tggatgaaaa actgtatgat cagataagtc tgccattcag tacagcgttc     2040

ggagcagata cagagggttc tcagtggata attggctacc tcttacaaaa agtcatcagt     2100

aacctctcag tctggagtag tgagcaggac cttgcaaatg acactgtgca gctccttgtc     2160

actttggtgg aaagaagaga aagggcaaac ttagtaattc aatgtgagaa ctggtggaat     2220

ttagctaagc agtttgcaag ccgaagccca cctcttaatt tcttgtcaag tcctgtgcag     2280

aggacattga tgaaggctct agtcttagga ggttttgcac atatggacac agaaaccaaa     2340

cagcagtatt ggacagaggt tcttcagcca cttcagcagc gattcttaag agtgataaac     2400

caagaaaact tccagcagat gtgtcagcaa gaggaagtca agcaggaaat cactgccaca     2460

ctagaggccc tgtgtggcat tgctgaggct acccagattg acaacgtagc aatcctgttt     2520

aattttttaa tggacttcct taccaattgc attggattga tggaagttta caagaatacc     2580

ccagagactg tcaatctcat tatagaagtt tttgttgaag ttgcacataa acagatatgc     2640

tatcttggag agtccaaagc tatgaactta tatgaagcct gccttacttt gttgcaagtg     2700

tattctaaga ataatttagg gcggcaaaga atagatgtta cagcagaaga agagcaatac     2760

caagacctgc ttctcattat ggaacttctt actaacctgc tgtcaaaaga attcatagat     2820

ttcagtgata cagatgaagt gtttagagga catgagccag gtcaagcagc aaacagatct     2880

gtgtcagcag cggatgttgt gttgtatgga gtaaacctaa ttctgccctt gatgtcacag     2940

gatctcttga agtttccaac cctttgtaat cagtactaca aattaatcac atttatctgt     3000

gagatttttc ctgaaaaaat accacagctt cctgaggatc tgtttaaaag tctgatgtac     3060

tccctagaat taggaatgac atcaatgagt tcggaggttt gccagctttg cctggaggcc     3120

ttgacaccgt tagctgaaca gtgtgcaaaa gcacaagaaa cagactcacc actttttcta     3180

gcaacacggc actttcttaa gctggttttt gatatgctgg ttttgcaaaa gcacaacaca     3240

gagatgacca ctgcggctgg cgaagctttc tacacgttgg tgtgtttgca ccaggctgaa     3300

tattctgaac tggtcgaaac attactatca agtcagcaag acccagttat ttaccagaga     3360

ttagcagatg ccttcaacaa gctcactgca agcagcactc ctcctacgct ggatcggaag     3420

cagaagatgg ccttcttaaa gagtttagaa gaatttatgg caaatgttgg tggtctcctt     3480

tgtgtaaaat aaacaacaga actttatgct taatttagat cctttctgca aagtgcactg     3540

aattgctgaa agttgacttg agtcttgtcc tattcctcag ttcatttggc cattttggat     3600

tttggagagc ctgaaacttt gatatgtatg taatacagtg aaacaggaga ggtcaacttg     3660

gcatcagctt ctgctgttaa gtgttagcca caatctgtca tatatatgtc ttttagattc     3720

tgaatggtga tttaaaattt tcaaaatgaa attccatata tgtgcaaaca gatatgggca     3780

ccacgaaata catatgcagt gccttttttc cttttaacat aggtggctag ccaaagttta     3840

gaatttttgt cattaaatat gaaatggata tatgctaggc agtgtttctc aaaatctcca     3900

tagatcgcct gcatcacttg aggagctggt gaaaaggcag attcttaggc ccaactgtag     3960

accttcagag tcagaatgtc tggttgttgg gcccaggagt cttcatgtta ataagcttct     4020

ccctttcgtc accccaaaag ttttgaatca atgaaagaga cattgaaaac tcttaagagg     4080

ttttgtgctt tctagctttt cctccctttg atgattgggt tttataattc agcaggaagg     4140

ggaaacatca ccaggggttt gttggctttt tcttagcttg ctttcttgct tgcttgcttt     4200

cttgcttttc ttgctttctg tctctctctt tcttttctct ctctctctca catcaaccca     4260

gtgctgcagg ttttgtgtaa tacaagtcac taatcatact ctgatgcctg aacttgagga     4320

ggaaaataca tgtatatttt tgttccgtaa aaataacctt aggaactgta gccatttcat     4380

tgccttaatt ttaagaggaa aatacaaaaa cagctgattt gttttagtaa gaaaccacgt     4440

cttgatgctt cagagttggt ttagggtgtt agctgctatg aacctgttgc ccctttcgat     4500

cgtgtattta tgtaggttta tcagtgaaat gaaaggcttg tttccgtcta gtctaacttt     4560

ttgagtgtgt ttctatccag ccacatagcc catatctact ctaaatggct tgcttaagca     4620

ataattattt taaaggatgt gaatcactga ttcacacaga ctattgcacg ttggggcatt     4680

aggggcaata attcttatcc agacatggga gccagtgaat ttaatttcag agattaaaaa     4740

ttcactttag atcctctagt ttgatctctt aatcaggatt tttatacagc tgccaggctc     4800

ccctaattca gtgtgccagc ttacaatgtg gaaatgaaag ctaatttata cacagcaggc     4860

atatgaaact ccactcattg cagtactttc acagcacagt gacaggtaga ggactctggc     4920

acaggtgcac tcatgaaact ctgcttccac catgttcctg acacctatct attaaaccat     4980

tctgcaaata cggtttttct acctgattgc atatagcata tgtgtcatta catgtgatgc     5040

tgtgcaaaac tttgtataat tctgtgttat taacagttaa caaaactgga gcatctgaat     5100

tacatccaac ctgtgcatgt gatgttaggt agatgtgaat gcagggcctt gggccataac     5160

ttacatttct ctcaatttga ttagctttga gtcacaatta aggggaagca aaaacatctt     5220

gaaaagactg ctaggaagga aattaatatc agtcatccag aagtacacgt ttctgtattt     5280

taaaaaatac tttgatgcat ttatttttag gtgttttttt tttcccctta aaaaacttga     5340

agtgatatgc agcagtaatc tatttgtttt gcattgttct tggtgttttg tgtttcccag     5400

atccctcaag ctttctcagc tgttgtgaat tatgtgtatc tgtgtgtgtg ctaagtacag     5460

tctctttacc aaagggcact gaaacacaca attgactgga caggtccacg cgccatgaca     5520

aaactataat caagttatta aaactaaaga ggagtgggaa aggaatgcct tggtaagtaa     5580

aaaggcatct atatttaata acttttatcc agatggcaac atatttgcaa aatttgccca     5640

gatcctatta caatactaaa aatagaaaat ttcacctcca tattcctgag gtgtaatttc     5700

attagactag ttttagttta aaaagacctt cttcagattg gaccaaataa tacttataag     5760

atcagcagaa tgttgaatat tagctcactg gggtggggag aagccactac cattttttag     5820

gtgatgggga tgccactgag ttgcaacggc tagacctttt cagggtggtt gtgtccatgt     5880

ttgcctgatt ggatgcttat tcactttgtg ttttcttttg ttttattttg tccaattttg     5940

tctttagctg tgtttattaa cttctccggt cttgttttgt tttaatgctc ttggcccagt     6000

gggtgtcaag aacactggct taattcaagt cagttgattt tttttctatt aaaactgttg     6060

ttaaaatatt ttttaaaaca aaaacattat ttgtgccctc ttttatatat gtcaaaggga     6120

cactgtcaag tatttcattt ttagattttt gttttataaa atttctgttg ttcatatagt     6180

atcctttaac ctctagtttt ccatacatcc tttgtttgtt tctcatttta ttttccttga     6240

cccatttatt tcccaaggca caatcactaa agactttgta ctttcacagt ctgttaatgt     6300

ggtagcacct gtaactgtgt tcttgttctg ttaaaaggat tgatttgctt ttatagtcct     6360

tgtgctggat gagtggctgc ctcagtagca aaactacctg acagtatttg acagtgtcct     6420

ttccagcacc attatttggg tctttcaggg tggccatctc tgttagaaga cagtagcatg     6480

ttaacatcac tgcattgagt ttttgtctgg tgtaaagtat gacttttaat gtaaacaaac     6540

tgcaggtttt tttcaaacta attttaagaa tttagtctta tttcgttgta aactgtgtat     6600

ctaattatat tacattactc tgttcagatg ggatggttac taccacttgt ccatgatttt     6660

catttgaaaa gcaagtatct atatcatttc cccccagtca gcattattta acactcccct     6720

taactgtctt tgaactttct cttttaacaa aaatgtcaag tctttatagt tgtaatatca     6780

ccatgtttcc catttctgtt aatacttcta tgaaccccta aagtattgaa gggaactagc     6840

tgtcagtttc aaggattaca agtttgagtc tcctagtatt caacatcatt ctgaaccctg     6900

aaataatatt tttctctgtt aaacaatttt tatctgtttg ccacctctgt tgttagaggt     6960

ggttgtcaat tgaccttact aagttagctg tctttgatga ggaattattg ttattggttc     7020

ctgaataaaa cattaacctt ttaagtcaga aggaacctcg gtacttctta aggtttgttt     7080

gtgttttcta aaaccagaga ataaggaact gatttggcta tgaggtttaa cattataatt     7140

ttctgtaagc tttcccacaa aaaaacattg ttgatttgag gatataataa tgttttaatc     7200

tttttaaaat ataagtggtt attctctgac ttggtaacta tgttctgaaa acactgcatt     7260

taagaatttt taaaaattgg ttttctaaaa ttaaaatgtc caaattaggc atattgctga     7320

gctcaaattg atgtgaaatg ccatggttcc agttgaattt taagcatatt ttcatttaga     7380

tataaaatat atgaagtatg ctttgttgat tatagtgaga acccatgaca tagttaacca     7440

aagaatatgt ttggttcaaa taaaaataga agcttaatac tgggcattca tactttttaa     7500

agagaatgaa tgaagaaatc ggtttcctgc tgtagttctc tatgggtaag tcttagtaaa     7560

gacgagaatg ctgaagtcgg ccgtggcgat tccctcctag gaactgggag gtgtggcttg     7620

cccattaccc gcttgaagct cacatcttta ccctcctctc ccactgtggt ttgatcttca     7680

cctattccca ggccctccca gcaattggag aggtgtcttt ttttttggtt ttggtttttt     7740

ttctccccgt ctgcattctt aggcctctta gctattagga actgtcagat acatactagt     7800

agctaatttt cctagcctga aattatatac tgcatctgca ctatgtacct actagggatc     7860

tgacctcaag tgttttctga gcccaggctt cctggtgtgg tgtcttttac cacataaaat     7920

tattacaaat tgcaaatgtt ggtattgtga tttgattatc tgtacaaaga aagaagctct     7980

atgcagtgag tttgtggttt aatggtcaca aaaatgttag cactgctacc actcagcacg     8040

tgtaaaattt tttaaattta taaatattaa aattttaaac ttacactaag acttttcagt     8100

tttatttaaa gacccaggga tgagtgtact gtttaaatat ttacctctat taacataact     8160

aatgaaggta taaaattgca tttagttttt cagaagatgc tgcaatatga ttttaggaaa     8220

taaggctatg tattgagcca gttataggct gaatatcagg ttgataaaat tttatttgta     8280

tttttaaaat tcataaatgg gagttaaaat gtgtcttttc actaaatatt tttattacat     8340

ttttgttttg accatgtgtg atttgttcat gggtatttag ctagactctt ttatgaaatg     8400

cattgaaatg gtgctagttt gtttaccatt ataggaagat tgacactggg gacattacac     8460

ggtcctaaaa taattttaaa tttaaaaaaa tgaagacatc tgtacagata aaaatcaaga     8520

tttgcatcac cttctgggag aacccgtggt actcacagaa tatccagtat tagaaatata     8580

aaaattttgt ctatatttta taatatttat ctcagcccac agtcttagaa acagtttcac     8640

agttactagt taagtcatta tctttggtgc atatttagta aatactttta gcaagtcatt     8700

ctttttggcc tttcagggaa agtggtgaat taccatatta ctgtgtgcta gatagatcca     8760

ccctttgccc agtgttaaat cttgtaaaca tatgaagtga aaagttaatt tttaaagaaa     8820

atgcatcttt aaaatgttca tttttaacct gaatttgctt tgaatattct ttgatttgta     8880

atgttgttat ttagcttata ttgagattta ttccactcca aaggtggata aagaaaagtt     8940

gtttaagaaa accaattaga gtgtattttg aatttttgtt tctttcatta ccaagtgtgg     9000

ggccatacac acaggctaat catctgtcat ttgagaccca cagatgattt caaaggtccc     9060

aaataaatac acatctataa ctgtttttta aaagacatct ttaatggtgc tctccaaaaa     9120

tacaattcgg ttgcttatga gtgatgcctt tgacaggctg attagattat aaaacagttt     9180

tgttttttta aacatagggt ctcagattga gtcttgtgca ttctatgtaa tctcaaatgg     9240

cagttcagtt tgactttctt ttaaaactaa gtggaaatgg tatatttggt gaaactaatg     9300

aaagaatctt ttgctgggaa attccataca gcacccccag cagcatcctg tctcagtctg     9360

gcgtataatt caacctccta ctgagtgtcc ctgtaaatta tttttaatat atagcatgag     9420

agtgaactga ggtaagtcat tgatgtttcc cagagatgat gaatgaacaa aagcaaatag     9480

gatctgctaa acatttttat tcccacagta gtgagcagtt ttgttcttgt tttgataatg     9540

ttcatttctg cctaatctta ggcttcaaat acacctttaa gaaagcccaa gatgtattga     9600

gtagtagaac ttcttatttg tacacctgtt tataactgca ctgccctgga tgttatggtt     9660

atttctaagg actgacctgg taaagctact tgaactggta gactgcaggg tagaggcaga     9720

cctagattca atgtctaact aagctgctta gggcttacat taatttccac aggtctgtta     9780

tccatatcat gagtttataa gtgttcctcc caaagaaaaa atttaaaagt gatggatgaa     9840

atataatagt agatgctcaa taaattccat tgtatttaaa gatt                      9884


<210> 2568
<211> 2370
<212> DNA
<213> Homo sapiens

<400> 2568
gtcggtagag gcagaaggag aaggtcgggt tgtagaagct ggggtggccg gcagctcgct       60

catcggtgtt cgtgggcttt gtcggtccgt gcctcgtctc tccctggaaa gggagggagg      120

cttcgacgtc gagagggagc cgctgccgcg ttagttccga gcttgaagtc actaggactt      180

ctctcaaact tgtgtgctga ggagactcag atgttggcct cagctcctag gctgaactca      240

gcagatcggc ccatgaaaac ttctgtattg agacaaagga agggatctgt cagaaagcaa      300

cacttgttat cttgggcttg gcagcaagga agaggacagg tagtggagat cctgcaatct      360

gaaaagcaga ctgaaaggtg acaaagaagc tgaagatggg tggtggagag aggtataaca      420

ttccagcccc tcaatctaga aatgttagta agaaccaaca acagcttaac agacagaaga      480

ccaaggaaca gaattcccag atgaagattg ttcataagaa aaaagaaaga ggacatggtt      540

ataactcatc agcagctgcc tggcaggcca tgcaaaatgg ggggaagaac aaaaattttc      600

caaataatca aagttggaat tctagcttat caggtcccag gttacttttt aaatctcaag      660

ctaatcagaa ctatgctggt gccaaattta gtgagccgcc atcaccaagt gttcttccca      720

aaccaccaag ccactgggtc cctgtttcct ttaatccttc agataaggaa ataatgacat      780

ttcaacttaa aaccttactt aaagtacagg tataaaataa gacaaatgtt taaatttagt      840

tatgttcacg ggtagttgtc aattggtctg aaacaaattt gctagggaat ctatttgtgt      900

agaactaatt aatgtaaaaa aaatagacca tctcgtgttg tgtgcactgt gatataatgg      960

tagtatcagt gcaacttaaa ctaatgattg tacttgatat taagtgttct caactgagta     1020

acttttaagt ggaaaccaag tttagatttg gggagtggta aaggaatcag ctttttctat     1080

tgttagggga agacagtaat ttatcattca tggaccagta gattgttgaa agttggtgaa     1140

tcggattata agcttctagc taacacaagg attcagaatt aggtaaacat ctgaaggttt     1200

agtatattag aaacacccaa accagtaata tgctaacctg atgcactgct gaaagaaaat     1260

gtgaattttt cgtaataatt gcattttagt gaattgtaca gtgggtggaa agggcatttg     1320

gagctcatta gaatgagaca tagtacaccc caatggccct gtttattaaa tgtagtggat     1380

taagtgtctg tcaacaaata caccaaaacc attttttata gaaacagtat ttaatggtca     1440

ctcaatagct ttcaaaatac atttttgtat tacagcactg cacaagctat tctaatagtg     1500

ctctggcctc atcattcctg caaagcttgc tttggggagt tggataatgt gaaaatttta     1560

agtacctagg ggagaaagag ccatgtaaat atctgtaata aacttgtagc atatgtaaag     1620

ttttcttggc ctttatctta caaaaatgga gtattttagt atgaatttgc tgaatgtaag     1680

accgtggact gttttttata atatggccta attttaaagg tccaaaataa cttgttttta     1740

aagtttgccc ttgtgctaaa gtgccagtgt atgtatgtta tacttgattt ggttgtaaac     1800

tatatttcaa agtaaaccct agtgtaataa gttttataac taaaaaggtt taagctgcta     1860

aaactatttt taagagatgt gaaatgcagt atgggactat ctttttttcc tcctctaagc     1920

ccaaagatta actagagtcc ctccaacctt atagattgtt ggctttcaca atcttataac     1980

ctaggataca ggtagtttcg agtatggtgc cagtgatgtt ttgtttttgt ttggtcaagg     2040

ggtaggtgca acccaatgga ccacttatgc aaaagatgta aactcttgca taatacattg     2100

ataacatgtt ttgccaactt taaatgctta aacataagcg aaaccagtag caagtatgtg     2160

ggtcagctta aaaattttga ttgttaatgc cctattttct aatttggcac ctcttgatgc     2220

ctaagcaggt aagcagatgc ctaagctgta tttctccaaa taaatcaaga tgaagtactg     2280

cccaagttaa atattgatag cctaaagaca agtttatgta gtacttaatg tacatgatat     2340

gaagcataaa attaaataaa atttttcccc                                      2370


<210> 2569
<211> 1295
<212> DNA
<213> Homo sapiens

<400> 2569
gcatcagcag ctgtctgcca gtgttgacgg agggctcatg ggtgccaggc cgcttgctgg       60

ggctttttat ctgtcctcag gcattggcac agcagccctg ggagatgaat actattgtga      120

tcttcattct ccacacaagg acagggaagt gacgtgccag ggtcaaacaa ctacccaagg      180

acagagccag gatttgaacc aggccatcca gttccagaac cactgctctt cactgtcatt      240

gtggccattt tacagtgctc ctgcgggaag aagtgtcgcg gctccaggag gaagttcacc      300

ttctccggca gatgaaggag atgttggcga aggacctgga ggagtcgcag ggcggcaagt      360

cctctgaggt cctctcggcc accgagctca gggtccagct ggcccagaag gagcaggagc      420

tagccagagc caaagaagcc ttgcaggcca tgaaagctga tcggaagcgc ttaaagggcg      480

agaagacaga cctggtgagc cagatgcagc agctgtatgc cacactggag agccgcgagg      540

agcagctccg agacttcatc cgcaactatg agcagcaccg caaggagagc gaggatgcgg      600

tcaaagcgct ggccaaggag aaggacctgc tggagcgtga gaagtgggag ctgcggcgcc      660

aagccaagga ggccacagac cacgccacgg cactgcgctc ccagctggac ctcaaggaca      720

accggatgaa ggagctggag gccgagctgg ccatggccaa acagtcctta gctacgctga      780

ccaaggacgt ccccaagcgg cattccctcg ccatgccggg cgagacggtg ctcaatggca      840

accaggagtg ggtggtgcag gcggacctcc cgctgaccgc agccatccgg cagagtcaac      900

agactctcta ccactcacac ccccctcacc ctgcggaccg gcaagcggtc agggtgagcc      960

cctgccactc ccggcagccc tctgtcatct ccgacgcatc tgccgccgaa ggcgaccggt     1020

cgtccacacc gagcgacatc aactcccctc gacaccggac acactccctc tgcaacggcg     1080

acagtcccgg cccagttcag aagaacctgc acaaccctat tgtacagtca ctagaggatc     1140

ttgaagacca aaaacggaaa aagaagaaag agaagatggg attcggctcc atctcccgcg     1200

tcttcgccag agggaagcag cggaagtccc tcgaccccgg cctctttgat ggtaccgccc     1260

ctgattatta catagaggag gacgcggact ggtga                                1295


<210> 2570
<211> 3643
<212> DNA
<213> Homo sapiens

<400> 2570
gggagaggga aggtcaggct tgcctcctgt tcacaaggac aacctctgtc tcccttgtgg       60

cggcttctat gaaggtgggg actccaggct ttctctcgtc tgctttttgg atgccttcaa      120

gagaggccag ttagaggata tcaattgtgg caattcccca gagccctcat cagatggcat      180

tagcccgtca tgtgctgcag tggcacccag tttggaggaa attcggaacc agaagagtgt      240

gacagtgctc ctgcgggaag aagtgtcgcg gctccaggag gaagttcacc ttctccggca      300

gatgaaggag atgttggcga aggacctgga ggagtcgcag ggcggcaagt cctctgaggt      360

cctctcggcc accgagctca gggtccagct ggcccagaag gagcaggagc tagccagagc      420

caaagaagcc ttgcaggcca tgaaagctga tcggaagcgc ttaaagggcg agaagacaga      480

cctggtgagc cagatgcagc agctgtatgc cacactggag agccgcgagg agcagctccg      540

agacttcatc cgcaactatg agcagcaccg caaggagagc gaggatgcgg tcaaagcgct      600

ggccaaggag aaggacctgc tggagcgtga gaagtgggag ctgcggcgcc aagccaagga      660

ggccacagac cacgccacgg cactgcgctc ccagctggac ctcaaggaca accggatgaa      720

ggagctggag gccgagctgg ccatggccaa acagtcctta gctacgctga ccaaggacgt      780

ccccaagcgg cattccctcg ccatgccggg cgagacggtg ctcaatggca accaggagtg      840

ggtggtgcag gcggacctcc cgctgaccgc agccatccgg cagagtcaac agactctcta      900

ccactcacac ccccctcacc ctgcggaccg gcaagcggtc agggtgagcc cctgccactc      960

ccggcagccc tctgtcatct ccgacgcatc tgccgccgaa ggcgaccggt cgtccacacc     1020

gagcgacatc aactcccctc gacaccggac acactccctc tgcaacggcg acagtcccgg     1080

cccagttcag aagaacctgc acaaccctat tgtacagtca ctagaggatc ttgaagacca     1140

aaaacggaaa aagaagaaag agaagatggg attcggctcc atctcccgcg tcttcgccag     1200

agggaagcag cggaagtccc tcgaccccgg cctctttgat ggtaccgccc ctgattatta     1260

catagaggag gacgcggact ggtgatacgc gctcccctgc gcctgctgcc cgcaggcgtg     1320

tctgtgcgtg tgggcgtgtg tgcaagcgag cgtgggtgcg cgtgtggccg tgcgtggggt     1380

gcgtgtgcac gtgtgcgctg gcacacatgg gtgctgggtg tggccgagcg cctctaacaa     1440

gtgaaaacac gagtgtgaac ctctctcccc tgcgtcgcca cctctgtaat tgatgtacat     1500

accgcaaacc gtgtgtgaac ctgtcaactc tctgtcgtct ttggagcgat acagttgtgt     1560

tgttaatctg gtttattatt tttcttcagt gtttggtttt tctttttctt tttgtttggt     1620

tcgtcggttt gtttttgttt ttgttttttt ccccctttct cctcccctcc tcctttttat     1680

gaaacttgaa aacttgaagg actgctgtgt atttgtaaat aacaaaacta ttgtgcactc     1740

tgtgcttgta aatgtccctc gtccaaaccg ctactcctgg agcccgtctg gcagaggatg     1800

tggtctgttt ttgatgtccc ccctcccgcc cccctggtgt gaacgtgtgg gaccagaccc     1860

tgtcctgggg gtgcgcccaa gtcactttaa ccacaaaacg ccatcgtcgt cagggtaagc     1920

tctgctctct acaaagactc gcgagccggg ccaaggggcc ttgtcttggc tgggtttgtc     1980

agaggtcaaa ccggctcttt taaacggcct accagttttt aaattgcatt gccgtttctt     2040

tctttatgaa aaaaaagaaa aaaagaaaat tgtttcattt aatttatttg cacaaatgct     2100

gaaaacttat tctatctaaa ttattacata aatattggaa tgtctatttt tccatggggt     2160

gggcgggagg tgggtgtctc tgttgacttg tctgttctgt taccatgctg ctacccaact     2220

gtgcaaagta gtttagggtg gccagaaccc agggaccatt ggatttcaaa gcttgctttt     2280

tctgttggtt cttctctctc cttctctctc tgtctctccc attctcctgc ccatgcatga     2340

aaggatcctc caccttcttc ccacccagag ctccctccag gcctttctct atatatttat     2400

ttatctgaca tacagaacac gactttagtg agcagagtgc tgacagtcat ggtccccttc     2460

tttgggtctg tcttttgaga gaggttgagt tcagggcaag acagcctgcc acacatccaa     2520

gggtacgacc agtgggaccc tggcctgagt ctgttctccg aggggcctcc agcagcttct     2580

gttcctccct gcagctgtgt ctttcttgtc ctgggtttag gatgcaggtg ggccaggcag     2640

gtgttgttag gggaggcacc cacttcaaaa ggagggccac agtggggaca cagagtccag     2700

cacctgagcc ctccaccctc cccattctgg ttggttccat cagccacact tagaatctcc     2760

caggatccct tggactccgt cccccaactt gtcacagcag cctgagccta cccaccccag     2820

gagacaagag ctggcaggaa catctgccta tatggggggt ggcgttggcc ccaaagaggc     2880

ttcaccagca aaggaactgt gtgtatttta atgccagggg acggaggatg tgtgagctgt     2940

tcagcaaggt ctgcccaagg cctaaaactc aatttcctta ttcttttgct tctgctcgtc     3000

cttaacaact aacagctcaa cccacacctc tagacaacag tagtcgtgct ttctgctaac     3060

ggtgacattt tcagctctta aaaagaagca aggagatttt caaatgctag agtatctcta     3120

tcagaaggca taggacattg tgtccaaagt ctcaagaaca aacaacactt tccttctgac     3180

ctggtccaaa agtcagcaaa cagcaagcag gcagaggccc tcataaggac ttttctgtcc     3240

tcctttgacc aaactgttta accgagccta ggggtgacgg ggagcgaccc aagctggcat     3300

ctttctctac ggagacagat tttagaaaat acttttcttg cccatgaatt tcttttctgg     3360

ttgattttta tcattttccc tttacttaca agaaaataag attgcaacca ctcctgctaa     3420

tgatttagta gttccttttc atttcagttt ttgtaaatta ggagataatt ctaagagtta     3480

ctaaaggatg atttatttaa gagaactacg tcaaatagcg aatgagttat gggtaacatt     3540

agacgaaaat aacctttccc gtgggaaagg tttctcgaag gcatggatgc aaatataaaa     3600

tattaaaaaa aatctaaata aagcttattt taaaatatga tcg                       3643


<210> 2571
<211> 984
<212> DNA
<213> Homo sapiens

<400> 2571
cctgggacac ggagcttgca gtgagctgat acggtgccac tgcactccag cctgggcaac       60

agagtgagac tccgtctcaa aaaaaaaaat cagattttta ggaattacac attagtggag      120

tagttagcag agcccatttt tctgagaatt aggctctaac ttttagttgt aatttagata      180

agttccaaaa taagttttta aacatttaag cttctttgca tgattttatc catttacgtt      240

attcaggata agcatctatt tgtttatcaa gtaatgtttt ctttcaactt tgttttttgt      300

ggcagatgtt tataaattct tctgtgggat cagagggcac gcctattaca accagaaaac      360

tacaagtata acagcgagga tggatgaaca ggctctatta gggctaaatc caaatgctga      420

ttcagacttt agacaaaggg ccctggccta ttttgagcag ttaaaaattt ccccagatgc      480

ctggcaggtg tgtgcagaag ctctagccca gaggacatac agtgatgatc atgtgaagtt      540

tttctgcttt caagtactgg aacatcaagt taaatacaaa tactcagaac taaccactgt      600

tcaacaacag ctaattaggg agacgctcat atcatggctg caagctcaga tgctgaatcc      660

ccaaccagag aagaccttta tacgaaataa agccgcccaa gtcttcgcct tgctttttgt      720

tacagagtat ctcactaagt ggcccaagtt tttttttgac attctctcag tagtggacct      780

aaatccaagg ggagtagatc tctacctgcg aatcctcatg gctattgatt cagagttggt      840

ggatcgtgat gtggtgcata catcagagga ggctcgtagg aatactctca taaaagatac      900

catgagggaa cagtgcattc caaatctggt ggaatcatgg taccaaatat tacaaaatta      960

tcagtttact aattctgaag tgac                                             984


<210> 2572
<211> 2048
<212> DNA
<213> Homo sapiens

<400> 2572
agttgtcggg tcttattggc cgctgattag accagccggg gtccactagc cctgggcttc       60

agggaggctg ctgcgtccag tgaacacttc agcacctgta gcacagaagg gccaaggagc      120

tgcagtcctc gaccagcagg aggtttgctc ctcagcccac tcgctgcatc cagatcagct      180

cacccctctc ccttccctgc ccaccaggac tctgatagcc cctggcagcc acagcccatt      240

ttgccaagat gtctagagta gccaaatatc gccggcaggt gagtgaagac cccgacatcg      300

acagcctgct ggagaccctg tctcccgagg agatggagga gctggagaag gagctggacg      360

tggtggaccc agacgggagt gttcccgtgg ggctgcggca gagaaaccag acggagaaac      420

agtccacggg tgtgtacaac cgggaggcca tgctcaactt ctgtgaaaag gagaccaaga      480

aacttatgca gagggagatg tccatggatg aaagcaagca agtggagacc aagacagatg      540

ccaagaatgg agaggaaagg ggcagagatg ccagcaaaaa agccctgggc cccagacggg      600

actcagatct ggggaaggag ccaaagaggg gtggtttaaa gaaaagcttc tctagagaca      660

gagatgaagc tggtggcaag agtggcgaga agcccaagga ggagaagatc atccggggca      720

ttgacaaggg ccgggtcagg gctgcagtgg ataagaagga ggcagggaag gatgggagag      780

gagaggagag ggcagtggcc accaagaagg aagaggagaa gaaagggagt gacaggaaca      840

caggcttgag cagggacaag gataaaaaga gagaggagat gaaggaggtg gccaagaaag      900

aggatgatga gaaggtaaaa ggggagcgta ggaacacaga caccagaaaa gagggtgaga      960

agatgaaaag agcaggtggg aacacagaca tgaaaaagga ggatgagaag gtaaaaagag     1020

gaactgggaa cacagacacc aaaaaggacg atgaaaaagt caagaagaat gaacccttac     1080

atgaaaagga agccaaggat gacagcaaga ccaaaacacc cgagaaacag acgcccagtg     1140

gccccaccaa gccctctgaa ggaccggcca aggtggagga ggaggcagct cccagcatat     1200

ttgatgagcc tctggagaga gtgaagaaca atgaccccga gatgactgag gtgaacgtca     1260

acaactcaga ctgcatcaca aatgagatct tggtccggtt tactgaggct ctggagttca     1320

acactgtggt taagctgttc gccttggcca acacgcgagc cgatgaccac gtggcctttg     1380

ccattgccat catgctcaag gccaacaaga ccatcaccag cctcaacctg gactccaacc     1440

acatcacagg caaaggcatc ctggccatct tccgggccct cctccagaac aacacgctga     1500

ccgagctccg cttccacaac cagcgacaca tctgtggagg caagacggag atggagatcg     1560

ccaagctgct gaaggagaat actaccctgc tcaagctggg ctaccatttt gagctggccg     1620

ggccccgaat gactgtcacc aatctgctca gccgcaacat ggacaagcag agacaaaagc     1680

ggctgcagga gcaaaggcag gcacaggaag ccaagggaga gaagaaggat ctgctggagg     1740

tacccaaggc cggggccgtg gctaagggct ccccaaaacc ttcacctcaa ccatctccaa     1800

agccctctcc aaagaactca cccaaaaaag ggggtgctcc agctgcccca ccaccccctc     1860

cccctccctt ggctccaccc cttatcatgg agaacctgaa gaattcactc tcaccagcta     1920

cccagaggaa gatgggagac aaagtcctcc ctgcccagga gaagaactcc cgtgaccagc     1980

tattggctgc catccgctcc agcaacctca agcagctcaa gaagctagag cttccactgt     2040

tgcttcag                                                              2048


<210> 2573
<211> 886
<212> DNA
<213> Homo sapiens

<400> 2573
gttgcctaaa cctctgccac ccacctgtga acttcacttt gccacaggga ggcactgaac       60

tgaaaaactg ccttgtaaga ggtgtcgccc ctctgtctac tccctttctt atatcaagag      120

gggaaaaaca cgtaactacc tctacccgat ctggtcacca tacgcctatt acctttactg      180

ttacaagtac cggatcactc tccgggagaa gatgctgcct cgttgttata aaagcatcac      240

ttataaggaa gaggaggact tgacactcca gccccgttcc tgcctccagt gctcctgagt      300

ccctagtagg cctccaggag ggcaaaagca ccgagcaggg taaccacgac cagcttaaag      360

aactgtattc ggctgggaac ttgacggtgc tggctactga ccccctgctc caccaggacc      420

cagtacagtt agactttcac ttccgcctta cctcccagac ctctgcccat tggcacggcc      480

ttctctgtga ccgtcgactc ttcttggata tcccatatca ggccttggat caaggcaacc      540

gggaaagttt gactgcaacc ctggagtacg tggaagagaa gacaaatgtg gactctgtgt      600

ttgtgaactt ccagaatgat cggaacgaca gaggtgccct gctgcgggcc ttcagctaca      660

tgggctttga ggtggtcaga ccagatcacc ctgccctccc tcccttggac aatgtcatct      720

ttatggtgta tccccttgaa agggatgttg gccacctgcc cagtgagcct ccttgaacat      780

gcttattcca acgctttgag gggctggaag ccttgacaca tggaatcagg ggcccgggat      840

gtgattcagg acactttcca tcctaggaat aaagggtagt gcaatc                     886


<210> 2574
<211> 2539
<212> DNA
<213> Homo sapiens

<400> 2574
gcctccccag cgtcggctcc ccggcgggcg gtgcgggccc tcccactcta ccccgcgccg       60

tctcacggcc ccggccctag cttcaccccg actacccggc gtgcgcgtcc tcctgccggc      120

ctgcaggccc ggggcctccg cctgcttccc cacagctgct ccttgcggcc ccgcttgcgt      180

tcacgctgtc gcccgggccg gcgcggccgc gggcaaccgc tccccctccc acacctaccc      240

cgccccctcc ccgccttttc cgccctccgg tccccctccc tcggcccgct gctgctgctc      300

cagatgaggt gatggcaacg gccaacttcg gcaagatcca gatcgggatt tacgtggaga      360

tcaagcgcag cgatggccga atacatcaag caatggtaac atctttaaat gaagataatg      420

aaagtgtaac tgttgaatgg atagaaaatg gagatacaaa aggcaaagag attgacctgg      480

agagcatctt ttcacttaac cctgaccttg ttcctgatga agaaattgaa cccagtccag      540

aaacacctcc acctccagca tcctcagcca aagtaaacaa aattgtaaag aatcgacgga      600

ctgtagcttc tattaagaat gaccctcctt caagagataa tagagtggtt ggttcagcac      660

gtgcacggcc cagtcaattt cctgaacagt cttcctctgc acaacagaat ggtagtgttt      720

cagatatatc tccagttcaa gctgcaaaaa aggaatttgg acccccttca cgtagaaaat      780

ctaattgtgt gaaagaagta gaaaaactgc aagaaaaacg agagaaaagg agattgcaac      840

agcaagaact tagagaaaaa agagcccagg acgttgatgc tacaaaccca aattatgaaa      900

ttatgtgtat gatcagagac tttagaggaa gtttggatta tagaccatta acaacagcag      960

atcctattga tgaacatagg atatgtgtgt gtgtaagaaa acgaccactc aataaaaaag     1020

aaactcaaat gaaagatctt gatgtaatca caattcctag taaagatgtt gtgatggtac     1080

atgaaccaaa acaaaaagta gatttaacaa ggtacctaga aaaccaaaca tttcgttttg     1140

attatgcctt tgatgactca gctcctaatg aaatggttta caggtttact gctagaccac     1200

tagtggaaac tatatttgaa aggggaatgg ctacatgctt tgcttatggg cagactggaa     1260

gtggaaaaac tcatactatg ggtggtgact tttcaggaaa gaaccaagat tgttctaaag     1320

gaatttatgc attagcagct cgagatgtct ttttaatgct aaagaagcca aactataaga     1380

agctagaact tcaagtatat gcaaccttct ttgaaattta tagtggaaag gtgtttgact     1440

tgctaaacag gaaaacaaaa ttaagagttc tagaagatgg aaaacagcag gttcaagtgg     1500

tgggattaca ggaacgggag gtcaaatgtg ttgaagatgt actgaaactc attgacatag     1560

gcaacagttg cagaacatcc ggtcaaacat ctgcaaatgc acattcatct cggagccatg     1620

cagtgtttca gattattctt agaaggaaag gaaaactaca tggcaaattt tctctcattg     1680

atttggctgg aaatgaaaga ggagctgata cttccagtgc ggacaggcaa actaggcttg     1740

aaggtgctga aattaataaa agccttttag cactcaagga gtgcatcaga gccttaggta     1800

gaaataaacc tcatactcct ttccgtgcaa gtaaactcac tcaggtgtta agagattctt     1860

tcataggtga aaactctcgt acctgcatga ttgccacaat ctctccagga atggcatcct     1920

gtgaaaatac tcttaataca ttaagatatg caaatagggt caaagaattg actgtagatc     1980

caactgctgc tggtgatgtt cgtccaataa tgcaccatcc accaaaccag attgatgact     2040

tagagacaca gtggggtgtg gggagttccc ctcagagaga tgatctaaaa cttctttgtg     2100

aacaaaatga agaagaagtc tctccacagt tgtttacttt ccacgaagct gtttcacaaa     2160

tggtagaaat ggaagaacaa gttgtagaag atcacagggc agtgttccag gaatctattc     2220

ggtggttaga agatgaaaag gccctcttag agatgactga agaagtagat tatgatgtcg     2280

attcatatgc tacacaactt gaagctattc ttgagcaaaa aatagacatt ttaactgaac     2340

tgcgggataa agtgaaatct ttccgtgcag ctctacaaga ggaggaacaa gccagcaagc     2400

aaatcaaccc gaagagaccc cgtgcccttt aaaccggcat ttgctgctaa aggataccca     2460

gaaccctcac tactgtaaca tacaacggtt cagctgtaag ggccatttga aagtttggaa     2520

ttttaagtgt ctgtggaaa                                                  2539


<210> 2575
<211> 2251
<212> DNA
<213> Homo sapiens

<400> 2575
gggacaccgg ggcgggggca ccgggaggaa gctgccttgg aagaggtggg ggcggcgacg       60

ggaggggcgg cgagcccccg ggagcctggg cgttaggccc gggcgtggcg gggccccggc      120

ggcctggggg gtctcctggg ccccccccca cccatggagc ccgccgcccc ggaggtcggt      180

ctcagatgac tgaactgggc accgagcgcc cctggtgtcc ctcgcagtgg actgacgccg      240

caggggcgag ctagccggct ccgcgcctct ccgcgggatc cagacgcctc ctggggctgc      300

tggcggaggg tctgaggcgg cgcggccatg gctcacctcc ggggatttgc caaccagcac      360

tctcgagtgg accctgagga gctcttcacc aagctcgacc gcattggcaa gggctcgttt      420

ggggaggtct acaagggcat cgataaccac acaaaggagg tggtggccat caagatcatc      480

gacctggagg aggccgagga tgagatcgag gacatccagc aggagatcac tgtcctcagt      540

cagtgcgaca gcccctacat cacccgctac tttggctcct acctaaagag caccaagcta      600

tggatcatca tggagtacct gggcggcggc tcagcactgg acttgcttaa accaggtccc      660

ctggaggaga catacattgc cacgatcctg cgggagattc tgaagggcct ggattatctg      720

cactccgaac gcaagatcca ccgagacatc aaagctgcca acgtgctact ctcggagcag      780

ggtgacgtga agctggcgga ctttggggta gcagggcagc tcacagacac gcagattaag      840

aggaacacat tcgtgggcac ccccttctgg atggcacctg aggtcatcaa gcagtcggcc      900

tacgacttca aggctgacat ctggtccctg gggatcacag ccatcgagct ggccaagggg      960

gagcctccaa actctgacct ccaccccatg cgcgtcctgt tcctgattcc caagaacagc     1020

ccacccacac tggagggcca gcacagcaag cccttcaagg agttcgtgga ggcctgcctc     1080

aacaaagacc cccgattccg gcccacggcc aaggagctcc tgaagcacaa gttcatcaca     1140

cgctacacca agaagacctc cttcctcacg gagctcatcg accgctataa gcgctggaag     1200

tcagaggggc atggcgagga gtccagctct gaggactctg acattgatgg cgaggcggag     1260

gacggggagc agggccccat ctggacgttc ccccctacca tccggccgag tccacacagc     1320

aagcttcaca aggggacggc cctgcacagt tcacagaagc ctgcggagcc cgtcaagagg     1380

cagccgaggt cccagtgcct gtccacgctg gtccggcccg tcttcggaga gctcaaagag     1440

aagcacaagc agagcggcgg gagcgtgggt gcgctggagg agctggagaa cgccttcagc     1500

ctggccgagg agtcctgccc cggcatctca gacaagctga tggtgcacct ggtggagcga     1560

gtgcagaggt tttcacacaa cagaaaccac ctgacatcca cccgctgaag cgcactgctg     1620

ttcagatagg ggacggaagg tcgtttgttt ttgttctgag ctccataaga actgtgctga     1680

cttggaaggt gccctgtgct atgtcgtgcc tgcagggaca cgtcggatcc cgtgggcctc     1740

acatgccagg tcaccaggtc accgtctcct tccacccctg cagtgtgctg ttgtgcacgt     1800

cagggacgct gttctctatg cccactgccc tcctccctct cctggcccag cagtattgct     1860

cacgggggct ccagccgccg gcgtggccct catgagctac gcctgggtct tctgcagact     1920

catgcagccc tatggccgct cagaccaagg cgcagagcaa ctatcagggc agctctgcct     1980

cctcctccca tgaggtgggg agaggcaaca gggcagcccc cagaggagtg tcctggccgc     2040

tgtcctcccg gggcccatga tggccataga tttgccttgt ggtgttggat caggtactgt     2100

gtctgctcat aagtacttgt gtcatccaga atgttttgtt ttttaagaaa attgaattac     2160

ttgtttcctg aaatattctg aggttaatat gttagttttc atagaacatt gagaggcccc     2220

tgccactttc aataaagacc tgacttggag a                                    2251


<210> 2576
<211> 1685
<212> DNA
<213> Homo sapiens

<400> 2576
gcgccggcac acctattggc ccccgcggcg tcccgtcgcc gcgtcgcgtt gctggcccgt       60

cggagcgacg ccgctcgggt cagtcggcgg ccggactggg aagatggacg cagctactct      120

gacctacgac actctccggt ttgctgagtt tgaagatttt cctgagacct cagagcccgt      180

ttggatactg ggtagaaaat acagcatttt cacagaaaag gacgagatct tgtctgatgt      240

ggcatctaga ctttggttta catacaggaa aaactttcca gccattgggg ggacaggccc      300

cacctcggac acaggctggg gctgcatgct gcggtgtgga cagatgatct ttgcccaagc      360

cctggtgtgc cggcacctag gccgagattg gaggtggaca caaaggaaga ggcagccaga      420

cagctacttc agcgtcctca acgcattcat cgacaggaag gacagttact actccattca      480

ccagatagcg caaatgggag ttggcgaagg caagtccata ggccagtggt acgggcccaa      540

cactgtcgcc caggtcctga agaagcttgc tgtcttcgat acgtggagct ccttggcggt      600

ccacattgca atggacaaca ctgttgtgat ggaggaaatc agaaggttgt gcaggaccag      660

cgttccctgt gcaggcgcca ctgcgtttcc tgcagattcc gaccggcact gcaacggatt      720

ccctgccgga gctgaggtca ccaacaggcc gtcgccatgg agacccctgg tacttctcat      780

tcccctgcgc ctggggctca cggacatcaa cgaggcctac gtggagacgc tgaagcactg      840

cttcatgatg ccccagtccc tgggcgtcat cggagggaag cccaacagcg cccactactt      900

catcggctac gttggtgagg agctcatcta cctggacccc cacaccacgc agccagccgt      960

ggagcccact gatggctgct tcatcccgga cgagagcttc cactgccagc acccgccgtg     1020

ccgcatgagc atcgcggagc ttgacccgtc catcgctgtg gggtttttct gtaagactga     1080

agatgacttc aatgattggt gccagcaagt caaaaagctg tctctgcttg gaggtgccct     1140

gcccatgttt gagctggtgg agctgcagcc ttcacatctg gcctgccccg acgtcctgaa     1200

cctgtcccta ggtgagagct gccaagtcca ggtggggtcc ctcggagatt cttctgatgt     1260

agagcgactg gaaagattct tcgactcaga agatgaagac tttgaaatcc tgtccctttg     1320

aaaatcctgg ggtcgggggt ggcacctgtg agagcctggg gctcctggtg ccgctgcgtt     1380

tcatccatcc cgcccgctcg cctgccgagg gctgcgcccc gtgctgcctc cccccagagg     1440

gccacccgct gtgctcgtgg actgaggctg cgctgcccgg gaggccttac tgcttggtgt     1500

cagactgccc agctcagagt gcccgtcagg gcctgtgcat ccgcacgcgg agccgtctgt     1560

taggagcttc cagagtgttc tctcgacact gccagccccg tgttagcacc tgggcctcag     1620

tcccacttgc tcccaggcgc cggttctgtg gttggtttgg aattaaagtc ctgtttgaag     1680

ttgtc                                                                 1685


<210> 2577
<211> 1883
<212> DNA
<213> Homo sapiens

<400> 2577
ggtcagacat gccagcaggg ttggaaagag gcaggtacgg aagctgagct gcagagttag       60

ccggcatctg acagaaaaat gtgagtgtgc tgtggaaggc ttgcatttcc tttaaggttt      120

gtctacagat tttgagcgtt cgaagttgac ccctgactaa gtatactttg ctgctccctc      180

agcctttgaa aaaatgtctg tcacatatga tgattccgtt ggagtagaag tgtccagcga      240

cagcttctgg gaggtcggga actacaagcg gactgtgaag cggatcgacg atggccaccg      300

cctgtgcagc gacctcatga actgcctgca tgagcgggcg cgcatcgaga aggcgtatgc      360

gcagcagctc actgagtggg cccggcgctg gaggcagctc gtggagaaag ggccccagta      420

cgggaccgtg gagaaggcct ggatggcctt catgtccgag gcagagaggg tgagcgagct      480

gcacctcgag gtgaaggcct cactgatgaa cgatgacttc gagaagatca agaactggca      540

gaaggaagcc tttcacaagc agatgatggg cggcttcaag gagaccaagg aagctgagga      600

cggctttcgg aaggcacaga agccctgggc caagaagctg aaagaggtag aagcagcaaa      660

gaaagcccac catgcagcgt gcaaagagga gaagctggct atctcacgag aagccaacag      720

caaggcagac ccatccctca accctgaaca gctcaagaaa ttgcaagaca aaatagaaaa      780

gtgcaagcaa gatgttctta agaccaaaga gaagtatgag aagtccctga aggaactcga      840

ccagggcaca ccccagtaca tggagaacat ggagcaggtg tttgagcagt gccagcagtt      900

cgaggagaaa cgccttcgct tcttccggga ggttctgctg gaggttcaga agcacctaga      960

cctgtccaat gtggctggct acaaagccat ttaccatgac ctggagcaga gcatcagagc     1020

agctgatgca gtggaggacc tgaggtggtt ccgagccaat cacgggccgg gcatggccat     1080

gaactggccg cagtttgagg agtggtccgc agacctgaat cgaaccctca gccggagaga     1140

gaagaagaag gccactgacg gcgtcaccct gacgggcatc aaccagacag gcgaccagtc     1200

tctgccgagt aagcccagca gcacccttaa tgtcccgagc aaccccgccc agtctgcgca     1260

gtcacagtcc agctacaacc ccttcgagga tgaggacgac acgggcagca ccgtcagtga     1320

gaaggacgac actaaggcca aaaatgtgag cagctacgag aagacccaga gctatcccac     1380

cgactggtca gacgatgagt ctaacaaccc cttctcctcc acggatgcca atggggactc     1440

gaatccattc gacgacgacg ccacctcggg gacggaagtg cgagtccggg ccctgtatga     1500

ctatgagggg caggagcatg atgagctgag cttcaaggct ggggatgagc tgaccaagat     1560

ggaggacgag gatgagcagg gctggtgcaa gggacgcttg gacaacgggc aagttggcct     1620

atacccggca aattatgtgg aggcgatcca gtgatgagtc ggggacaggc cagcgggggg     1680

acggaggcgg cgggcccagg agcctcagcc agccacgtgg gcatccactc cttttcctgc     1740

aagagatgat ggttccattg ctcttggctt catggtgttc ctggaaggca gatgagctgg     1800

tcatttcgcc tgggactcgg cacctttccg agtgcagctg gagggatctg agcgcaggaa     1860

gacgcagaac aacagaaata gcc                                             1883


<210> 2578
<211> 3355
<212> DNA
<213> Homo sapiens

<400> 2578
acactgtcct ctcacagaac aagaaggtat ctggtctaca agaactcgag gcctcactga       60

aacggaaagc aaatacaaag aaactttatt ttaaaaacat gtcttggtct cccaagaaga      120

gggcaattgg attgctcagc cagaatgaag agtagtttta cagaaaaaag aggacaatat      180

tgggatcacc tttgaccttt ccatttggaa ataatatttt ctattgtgtt atagaaaggt      240

gggaagcttt catccagaac aatgaatttc ataaaggaca atagccgagc ccttattcaa      300

agaatgggaa tgactgttat aaagcaaatc acagatgacc tatttgtatg gaatgttctg      360

aatcgcgaag aagtaaacat catttgctgc gagaaggtgg agcaggatgc tgctagaggg      420

atcattcaca tgattttgaa aaagggttca gagtcctgta acctctttct taaatccctt      480

aaggagtgga actatcctct atttcaggac ttgaatggac aaagtctttt tcatcagaca      540

tcagaaggag acttggacga tttggctcag gatttaaagg acttgtacca taccccatct      600

tttctgaact tttatcccct tggtgaagat attgacatta tttttaactt gaaaagcacc      660

ttcacagaac ctgtcctgtg gaggaaggac caacaccatc accgcgtgga gcagctgacc      720

ctgaatggcc tcctgcaggc tcttcagagc ccctgcatca ttgaagggga atctggcaaa      780

ggcaagtcca ctctgctgca gcgaattgcc atgctctggg gctccggaaa gtgcaaggct      840

ctgaccaagt tcaaattcgt cttcttcctc cgtctcagca gggcccaggg tggacttttt      900

gaaaccctct gtgatcaact cctggatata cctggcacaa tcaggaagca gacattcatg      960

gccatgctgc tgaagctgcg gcagagggtt cttttccttc ttgatggcta caatgaattc     1020

aagccccaga actgcccaga aatcgaagcc ctgataaagg aaaaccaccg cttcaagaac     1080

atggtcatcg tcaccactac cactgagtgc ctgaggcaca tacggcagtt tggtgccctg     1140

actgctgagg tgggggatat gacagaagac agcgcccagg ctctcatccg agaagtgctg     1200

atcaaggagc ttgctgaagg cttgttgctc caaattcaga aatccaggtg cttgaggaat     1260

ctcatgaaga cccctctctt tgtggtcatc acttgtgcaa tccagatggg tgaaagtgag     1320

ttccactctc acacacaaac aacgctgttc cataccttct atgatctgtt gatacagaaa     1380

aacaaacaca aacataaagg tgtggctgca agtgacttca ttcggagcct ggaccactgt     1440

ggagacctag ctctggaggg tgtgttctcc cacaagtttg atttcgaact gcaggatgtg     1500

tccagcgtga atgaggatgt cctgctgaca actgggctcc tctgtaaata tacagctcaa     1560

aggttcaagc caaagtataa attctttcac aagtcattcc aggagtacac agcaggacga     1620

agactcagca gtttattgac gtctcatgag ccagaggagg tgaccaaggg gaatggttac     1680

ttgcagaaaa tggtttccat ttcggacatt acatccactt atagcagcct gctccggtac     1740

acctgtgggt catctgtgga agccaccagg gctgttatga agcacctcgc agcagtgtat     1800

caacacggct gccttctcgg actttccatc gccaagaggc ctctctggag acaggaatct     1860

ttgcaaagtg tgaaaaacac cactgagcaa gaaattctga aagccataaa catcaattcc     1920

tttgtagagt gtggcatcca tttatatcaa gagagtacat ccaaatcagc cctgagccaa     1980

gaatttgaag ctttctttca aggtaaaagc ttatatatca actcagggaa catccccgat     2040

tacttatttg acttctttga acatttgccc aattgtgcaa gtgccctgga cttcattaaa     2100

ctggactttt atgggggagc tatggcttca tgggaaaagg ctgcagaaga cacaggtgga     2160

atccacatgg aagaggcccc agaaacctac attcccagca gggctgtatc tttgttcttc     2220

aactggaagc aggaattcag gactctggag gtcacactcc gggatttcag caagttgaat     2280

aagcaagata tcagatatct ggggaaaata ttcagctctg ccacaagcct caggctgcaa     2340

ataaagagat gtgctggtgt ggctggaagc ctcagtttgg tcctcagcac ctgtaagaac     2400

atttattctc tcatggtgga agccagtccc ctcaccatag aagatgagag gcacatcaca     2460

tctgtaacaa acctgaaaac cttgagtatt catgacctac agaatcaacg gctgccgggt     2520

ggtctgactg acagcttggg taacttgaag aaccttacaa agctcataat ggataacata     2580

aagatgaatg aagaagatgc tataaaacta gctgaaggcc tgaaaaacct gaagaagatg     2640

tgtttatttc atttgaccca cttgtctgac attggagagg gaatggatta catagtcaag     2700

tctctgtcaa gtgaaccctg tgaccttgaa gaaattcaat tagtctcctg ctgcttgtct     2760

gcaaatgcag tgaaaatcct agctcagaat cttcacaatt tggtcaaact gagcattctt     2820

gatttatcag aaaattacct ggaaaaagat ggaaatgaag ctcttcatga actgatcgac     2880

aggatgaacg tgctagaaca gctcaccgca ctgatgctgc cctggggctg tgacgtgcaa     2940

ggcagcctga gcagcctgtt gaaacatttg gaggaggtcc cacaactcgt caagcttggg     3000

ttgaaaaact ggagactcac agatacagag attagaattt taggtgcatt ttttggaaag     3060

aaccctctga aaaacttcca gcagttgaat ttggcgggaa atcgtgtgag cagtgatgga     3120

tggcttgcct tcatgggtgt atttgagaat cttaagcaat tagtgttttt tgactttagt     3180

actaaagaat ttctacctga tccagcatta gtcagaaaac ttagccaagt gttatccaag     3240

ttaacttttc tgcaagaagc taggcttgtt gggtggcaat ttgatgatga tgatctcagt     3300

gttattacag gtgcttttaa actagtaact gcttaaataa agtgtactcg aagcc          3355


<210> 2579
<211> 543
<212> DNA
<213> Homo sapiens

<400> 2579
caggcggcgg agcctccggg acggcgagcg gcgggcggcg gaggaggaga cggcagactg       60

accaaatatg gaagtgtgca agtcttgaac acattagttt atacaatgtg gcctgaaagt      120

ttccctcctc tttccaaatc aaccataata ttctgaggca ttaaaaaata tttaatcatt      180

catgtgttga gactcattct tgagttatgg atgacaaggc ttctgttgga aaaatcagtg      240

tctcttcaga ctcagtatct actcttaata gtgaagattt tgtcttggtt tccaggcaag      300

gagatgagac accatctaca aataatggaa gtgatgatga gaaaacagga ctcaagattg      360

tagggaatgg aagtgaacag cagctgcaaa aagagctagc agatgtactg atggatcctc      420

caatggacga ccagccaggg gaaaaggagc ttgtgaaaag gtcacaactg gatggtgaag      480

gagatgggcc tctttctaat cagctctccg cttcatccac cattaaccct gtgccattag      540

tag                                                                    543


<210> 2580
<211> 1002
<212> DNA
<213> Homo sapiens

<400> 2580
gtgcccacag gcctgcagcg ggtccaaacc tcaggccccc agcccgtgcc gcttcgcggg       60

gtccacttct cgggaaatgt cctccgagcc gcctgctggc ggtgtcccga tccccccggg      120

agtgggtcga agggccaggc cctccccagg gggtgctgtg cctagggctc gactgtccgc      180

tctctctccc tgcgcagctg gtgggcacgg aggatgctct tctgcagcag ctggcggact      240

cgatgctcaa agaggactgc gcctccgagc tgaaggtcca cttggcaaag tccctccctt      300

tgccctccag tgtgaatcgg ccccgaattg acctgatcgt gtttgtggtt aatcttcaca      360

gcaaatacag tctccagaac acagaggagt ccctgcgcca tgtggatgcc agcttcttct      420

tggggaaggt gtgtttcctc gccacaggtg ctgggcggga gagccactgc agcattcacc      480

ggcacaccgt ggtgaagctg gcccacacct atcaaagccc cctgctctac tgtgacctgg      540

aggtggaagg ctttagggcc accatggcgc agcgcctggt gcgcgtgctg cagatctgtg      600

ctggccacgt gcccggtgtc tcagctctga acctgctgtc cctgctgaga agctctgagg      660

gcccctccct ggaggacctg tgagggtggc tggcccctgg gctgcccctt ctcatggctt      720

cgtgctgact ccataaacat tctctgttga ggatgtccag tcagggcttg acaggcccag      780

gctcagcccg ccgtggctgg gaaggttccc tgcagtgcca gtgctgcagc agggagagct      840

gggcagaagc agcgaggggg cccagctggc gagactgtag ccccctccca ctcccacact      900

cactcttgca gagcctgtgt ctttaagcag ctggcgtgtt acatctccat ttaaggtttc      960

ctttgaacaa aaggtctgtg gctaaaaaaa gtttaaaaat ca                        1002


<210> 2581
<211> 2331
<212> DNA
<213> Homo sapiens

<400> 2581
atggcctcgg acacccaggc agtccctgac gtgtcgggga ggagccgggc gcggaggtac       60

gctgagtgga gctcggggct gcgtagtggc cgggccggcg gaggggagac gtcggttgag      120

cggcggcgaa catgcgcttt tgacacattg gaggctttct tgatcatgga tggtgaagat      180

ataccagatt tttcaagttt aaaggaggaa actgcttatt ggaaggaact ttccttgaag      240

tataagcaaa gcttccagga agctcgggat gagctagttg aattccagga aggaagcaga      300

gaattagaag cagagttgga ggcacaatta gtacaggctg aacaaagaaa tagagacttg      360

caggctgata accaaagact gaaatatgaa gtggaggcat taaaggagaa gctagagcat      420

caatatgcac agagctataa gcaggtctca gtgttagaag atgatttaag tcagactcgg      480

gccattaagg agcagttgca taagtatgtg agagagctgg agcaggccaa cgacgacctg      540

gagcgagcca aaagggcaac aatagtttca ctggaagact ttgaacaaag gctaaaccag      600

gccattgaac gaaatgcatt tttagaaagt gaacttgatg aaaaggaatc tttgttggtc      660

tctgtacaga ggttaaagga tgaagcaaga gatttaaggc aagaactagc agttcgggaa      720

agacaacagg aagtaactag aaagtcggct cctagctctc caactctaga ctgtgaaaag      780

atggactccg ccgtccaagc atcactttct ttgccagcta cccctgttgg caaaggaacg      840

gagaacactt ttccttcacc gaaagctata ccaaatggtt ttggtaccag tccactaact      900

ccctctgcta ggatatcagc actaaacatc gtgggggatc tcttacggaa agtaggggct      960

ttagaatcca aattagcagc ttgcaggaat tttgcaaagg accaagcatc acgaaaatcc     1020

tatatttcag ggaatgttaa ctgtggggtg ctgaatggca atggcacaaa gttctctcga     1080

tcagggcata catctttctt cgacaaaggg gcagtaaacg gctttgaccc cgctcctcct     1140

cctcctggtc tgggctcctc gcgtccatcg tcagcgccgg gtatgctgcc tctcagtgtg     1200

tgagtgccta gcctccaggt gggggctcct gccctcctcc aacaacccag gacacccacg     1260

cctcacccct cggtgcctgg gcccagcccc gtgcccctcc gtctgcctcc gcacggctgg     1320

cagagggcag gctgcatgca gtggcggcta ctgggccctg cccagccccg gaactctgcg     1380

cgatatcaat actggctatt ttctcttctc gccgtagtgc cgttggtttc acatgattgc     1440

acttttgtgg gtcgcaaggt gatacatacg tgtattactt ggtcactgga tgcagaagta     1500

cccattcatc acacctgccc catagccccc actctgctgt actgatagga tttagttgtg     1560

ttttaggaca ttgcaaatct tctagaagtt ctcccccaaa tcaggtcaat gtgtgccctc     1620

ctgagctccc acccaggcat ctccagtgct catgatcatg tgtcccccaa ctccacccct     1680

cacagtttgg gcctgtttct ggcaaagagt caggaaggtt actgaattag ggaacatttt     1740

ctgcaccttc tgattttact taagcagcta ccattccatg gacttgcctc ccagagcagc     1800

acaatgcccg tctgagcccc acgtggcagg agcctctggg acggggcaca cacaggccca     1860

gcctctgtgc tgtctcctcc tccgtgcgcc tcagactcgg ggtgagggag gcgggcagcc     1920

tctcgccagc cttcccgtcc ttcagttcaa cgacatcttt ggagtgtttt tgttttctct     1980

tccaagggcc gtcccgttgt gttaggaagg gtgagtggct ggttccaggg tgggccggtg     2040

ccagctccgg ggtggactga acagcggcgg ctgtccctgt gcatcctttg attactctca     2100

tgctgcattt actgtttaca tttgttttat tgtacatagg tttgtaaaca ttattgcctg     2160

agatatttgt atataacttg ggctttgtag cttttattta ttcagaacgc atacggcatg     2220

ttaatgactc tgatggtgtc ctcctctggg cagctgtata ggatcatcat gtggttacaa     2280

aaaatacttc cctcaaaaaa attcttttaa tgtggaaaca ataaatttca c              2331


<210> 2582
<211> 1606
<212> DNA
<213> Homo sapiens

<400> 2582
gggtttgaat ccccggcggc ggcgcggggc ggccgcggac cgtgagtcag cattggcggc       60

ggccccagcg cgtggcagcc gtgcgccgcc aaggttctgc gttagacctg catcttagca      120

atgtgaatat tgcatcccta gagaaggacc tggaagagca agacggccac gacctgggag      180

cagcaggtcc caggtcgctg gccggctctg cacctgtcgc catccccggc tccctgccca      240

gagcaccatc gctacactcg ccatcctctg cgtccacctc gccgctcggt tcgctgtccc      300

agcccctccc agggccggtg ggctcctcag ccatgacgcc tccccagcag ccgccacccc      360

tgcgttcaga gccgggcaca ctgggctctg cagcctcatc ctacagcccc ctaggtttga      420

acggtgtccc cgggagcatc tgggactttg tttccggcag cttctccccc agcccctccc      480

ccatcctgag tgccggcccc ccatcctctt cgagtgcaag tccaaacgga gctgagctgg      540

cccgggtcag gcggcagctg gacgaggcca agaggaagat ccggcagtgg gaggagtcct      600

ggcagcaggt gaagcaggtc tgcgatgcct ggcagcgaga ggcgcaggag gccaaggagc      660

gtgcccgtgt ggccgatagc gaccggcagc tggcgctgca gaagaaggag gaggtggagg      720

cacaggtgaa gcagctgcag gaggagctgg agggcctggg cgtagcctcc acactgccgg      780

ggctgcgggg ctgtggggac atcggcacca ttcccctgcc gaagctgcac tcgctgcaga      840

gtcagctgcg cctggacctg gaggcggtgg acggcgtgat cttccagctc cgcgccaagc      900

agtgtgtggc ctgccgggag cgggcccacg gtgctgtcct gcggccctgt cagcaccaca      960

tcctctgtga gccgtgtgcg gccaccgcac ctgagtgccc ctactgcaag ggccagcccc     1020

tgcagtggtg acctcagcgg ggacagccac ctcctgctgg gcaccctggc tccagcgctc     1080

ctcctgacca cggacatgtc gtcactcgct tctggtgcca ccgacgtgag gaccgaggct     1140

gggagccctt cctgttacac gttatcatga ggctgggagc cccgcctgcg cttggcctga     1200

cagcctttcc tgtcacacgt tgtcacctat ctagtcctac cgacggtttc aaggtatttt     1260

cctcaaaaac cttaaatgca aacccacaga acccgcctgc ctgtccctga ggggcctggt     1320

gcctccggga tccacgcggc gctgtgatca cagcagtttg tggtcctgac actactgtga     1380

ctaggccact gggagctggg gtctttcaaa gcactttgta aaccgaggaa tttagttaga     1440

ggttataaat tgctctaagc tgctttctgt ttttttttaa tatgcgataa tatgaagctt     1500

tatatgtgta ctgtgaactt aaatatttca tatcagttta ttgtcaattc atagtatgct     1560

aaatatatta gatttcatat tctgaaacta gtacttatga aatgag                    1606


<210> 2583
<211> 1634
<212> DNA
<213> Homo sapiens

<400> 2583
atgctgccct ggcctcctgc actggccatg cccatgccca cggagggcac cccgccacct       60

ctgagtggca cccccatccc agtcccagcc tacttccgcc acgcagaacc tggattctcc      120

ctcaagaggc ccagggggct cagccggagc ctcccacctc cgccccctgc caagggcagc      180

attcccatca gccgcctctt ccctcctcgg accccaggct ggcaccagct gcagccccgg      240

cgggtgtcat tccggggcga ggcctcagag actctgcaga gccctgggta tgacccaagc      300

cggccagagt ccttcttcca gcagagcttc cagaggctca gccgcctggg ccatggctcc      360

tacggagagg tcttcaaggt gcgctccaag gaggacggcc ggctctatgc ggtaaagcgt      420

tccatgtcac cattccgggg ccccaaggac cgggcccgca agttggccga ggtgggcagc      480

cacgagaagg tggggcagca cccatgctgc gtgcggctgg agcaggcctg ggaggagggc      540

ggcatcctgt acctgcagac ggagctgtgc gggcccagcc tgcagcaaca ctgtgaggcc      600

tggggtgcca gcctgcctga ggcccaggtc tggggctacc tgcgggacac gctgcttgcc      660

ctggcccatc tgcacagcca gggcctggtg caccttgatg tcaagcctgc caacatcttc      720

ctggggcccc ggggccgctg caagctgggt gacttcggac tgctggtgga gctgggtaca      780

gcaggagctg gtgaggtcca ggagggagac ccccgctaca tggcccccga gctgctgcag      840

ggctcctatg ggacagcagc ggatgtgttc agtctgggcc tcaccatcct ggaagtggca      900

tgcaacatgg agctgcccca cggtggggag ggctggcagc agctgcgcca gggctacctg      960

ccccctgagt tcactgccgg tctgtcttcc gagctgcgtt ctgtccttgt catgatgctg     1020

gagccagacc ccaagctgcg ggccacggcc gaggccctgc tggcactgcc tgtgttgagg     1080

cagccgcggg cctggggtgt gctgtggtgc atggcagcgg aggccctgag ccgagggtgg     1140

gccctgtggc aggccctgct tgccctgctc tgctggctct ggcatgggct ggctcaccct     1200

gccagctggc tacagcccct gggcccgcca gccaccccgc ctggctcacc accctgcagt     1260

ttgctcctgg acagcagcct ctccagcaac tgggatgacg acagcctagg gccttcactc     1320

tcccctgagg ctgtcctggc ccggactgtg gggagcacct ccaccccccg gagcaggtgc     1380

acacccaggg atgccctgga cctaagtgac atcaactcag agcctcctcg gggctccttc     1440

ccctcctttg agcctcggaa cctcctcagc ctgtttgagg acaccctaga cccaacctga     1500

gccccagact ctgcctctgc acttttaacc ttttatcctg tgtctctccc gtcgcccttg     1560

aaagctgggg cccctcggga actcccatgg tcttctctgc ctggccgtgt ctaataaaaa     1620

gtatttgaac cttg                                                       1634


<210> 2584
<211> 4974
<212> DNA
<213> Homo sapiens

<400> 2584
ggtgcgaagc cattcaccca gcgcattccg ccgcccgcag gcttgcgggg aaacttcctt       60

attattgtga cgccgaaaac ggagaaaccc cgggtccggc gagaggggct gtgacagtcg      120

gagtcccaag ctgcggttcg gctgctgccg agaactgcaa ggtgtggaat atttctggct      180

tctagtccaa tgccaagtgt gtgacctgtg gctacatgat tccctgaaag ataagaacaa      240

tgttatgttg gggatattgg tctctgggcc aacctggtat cagcaccaac ctgcagggaa      300

ttgtggctga gccccaggtg tgtgggttca tatctgacag aagtgtcaag gaagtggcct      360

gtgggggaaa ccactctgtg ttcctgctgg aagatgggga agtttacaca tgtggtttga      420

acaccaaggg gcaactgggc catgagaggg aaggaaacaa gccagaacaa attggagctc      480

tggcagatca gcatatcatt catgtggcat gtggcgagtc ccacagtctg gccctcagtg      540

accgaggcca gctgttttct tggggtgcag ggagtgatgg tcagctagga ctcatgacta      600

ctgaggattc tgtggcagtg cccaggttaa tacaaaagct gaaccagcaa acaatattac      660

aagtttcctg tggcaactgg cattgcttgg ctcttgcggc tgatggccag ttcttcacct      720

ggggaaagaa cagccatggg cagcttggct tagggaagga gttcccctcc caagccagcc      780

cacagagggt gaggtccctg gaggggatcc cactggctca ggtggctgcc ggaggggctc      840

acagctttgc cctgtctctc tcaggagctg tttttggctg ggggatgaat aatgccgggc      900

agctagggct cagtgatgaa aaagatcgag aatctccatg ccatgtaaaa ctcttacgca      960

cgcaaaaagt tgtctatatt agttgtggag aagaacacac agcagttctc acaaagagtg     1020

gaggtgtgtt tacctttggc gctggttcct gtgggcaact tggacacgac tccatgaatg     1080

atgaggttaa ccctagaaga gttctagagc tgatgggtag tgaagtaact caaattgctt     1140

gtggcagaca acatacccta gccttcgtgc cttcttctgg actcatctat gcatttggtt     1200

gtggagcaag aggtcaatta ggaactgggc acacttgtaa tgttaagtgc ccatctcctg     1260

tcaagggtta ctgggctgcc cacagtggcc agctttcagc ccgagctgat cgctttaaat     1320

atcatatcgt taagcagatc ttctctggag gagaccagac ttttgtactt tgctccaaat     1380

acgagaatta ttctcctgct gttgacttca ggactatgaa ccaagcacat tataccagtt     1440

taataaatga tgaaaccata gcagtttgga gacaaaaact ctcagaacac aacaatgcaa     1500

atacaatcaa tggtgttgtt cagatattat cttctgcagc ctgttggaat ggaagttttc     1560

ttgaaaaaaa aattgatgaa cattttaaaa cgagtcccaa aatccctggg attgacctga     1620

actcaactag ggtgttattt gagaagttaa tgaactctca gcactccatg attctagaac     1680

agattttgaa cagttttgaa agttgtctga ttccccagtt gtcaagctca ccaccagatg     1740

ttgaagccat gagaatctat ttaatactac ctgagtttcc cctactccag gattccaagt     1800

attatataac attgactatt cccttggcta tggccattct tcggctggat acaaacccca     1860

gcaaagtact agataactgg tggtctcagg tatgcccgaa atatttcatg aagctggtaa     1920

acctctataa aggtgcagtc ctttatctac tgaggggaag aaagacattc ttaattcccg     1980

tactgtttaa caattatatc acagcagctc tcaaactctt ggagaagtta tataaggtaa     2040

atcttaaagt gaagcatgtg gaatatgata cattttacat tcctgagatt tccaatctcg     2100

tggacattca ggaagactac ctcatgtggt tcttgcatca agcagggatg aaggctagac     2160

catcaataat acaggatact gtaacacttt gttcctaccc tttcatcttt gatgcccaag     2220

ccaagaccaa aatgttacag acagatgctg aactacagat gcaggtggca gtcaatggag     2280

ccaacctgca gaatgtcttc atgcttctca ccctggagcc tctgctggcc agaagcccct     2340

tcctggtcct tcacgttcgc aggaacaacc ttgttggaga tgccctaaga gagctgagca     2400

ttcattctga tattgatttg aaaaagcctc tcaaagtaat ctttgatggt gaagaagcag     2460

tggatgccgg tggtgttaca aaggaatttt ttcttttgct gttaaaagaa cttttgaatc     2520

ccatctatgg aatgtttacc tactatcaag attcaaatct cttgtggttt tcagacacgt     2580

gttttgtaga gcacaactgg tttcacttga ttggtataac ctgtggacta gctatctaca     2640

actccactgt ggtcgatctc cacttcccat tggctctcta caagaagtta ctcaatgtaa     2700

agcctggctt ggaagactta aaggagttgt cacccactga aggaaggagt ctccaagagc     2760

ttttagatta ccccggggag gatgtggagg agactttctg cctcaacttc acgatctgcc     2820

gagaaagcta tggagtgatt gaacagaaga agctgatacc tgggggagat aatgtaactg     2880

tgtgcaagga taacaggcag gaatttgtgg atgcttatgt gaattatgtc ttccaaatct     2940

cagttcatga atggtacaca gccttctcta gtggcttcct aaaggtgtgt ggtggcaaag     3000

tacttgagct cttccagcct tcagaactga gggctatgat ggtggggaac agcaactaca     3060

actgggaaga actggaagag actgccatct acaagggaga ttactcggcc acacatccca     3120

ctgtaaaact attttgggaa acatttcatg agtttccatt ggaaaagaag aagaagtttc     3180

tcttgttcct gacaggcagc gatcggattc ccatctacgg catggccagt ctgcagattg     3240

tcatccagtc cacagccagc ggggaggagt acttgccggt ggcccacact tgctacaacc     3300

ttcttgacct ccccaagtac agcagcaaag agattctgag tgcccggctg acccaggccc     3360

ttgacaacta tgaagggttt agtttggcct gaggcttctc agcttgtcca gtatttccct     3420

tcgttcctca gtgtccacat tgaggcctat acagaaaatc atggggagtg atttctattt     3480

ttttattgtc taagtgggtt gggactttta aatactgagc ctggttgatg tgtttctggg     3540

attgtatagc agtaaacaac ctttttgaaa aattagaggt tggggatggg gtgaaaaatt     3600

ggcccttgta tgggaggtgt ttttgttttt gttttaaacc aaactaccca gtattccttg     3660

cacttgtgaa tgtgttgcac tctgctggat gaaatggcag tggattttta aactttaatt     3720

tcccaaatgt ctctctcagc cctgatgttt tctcacagtg cttccttgtc cttctcttaa     3780

cttctcattc ctctataaga atgatttaga ctgacctgtc cttttttatc tgcgcatgcg     3840

agaacatcac cttcctctgt acacttggaa atgcctctgg cttgttgcag ccctccttta     3900

acccaaagga ggaaaggact gcttcagaaa ctcccaattc caaaaagctg agtctgggtc     3960

cattattttg gcagaactcc taagaattta tgggagccta tataaacata tcttgctttt     4020

aaaaagttct tgagggaata gcaactttcc catggctgtg cctatttcct agacctttta     4080

aaagatgtgc agagcagctt agcattcgtt gcagctgagc ctaatttttt cttgctcatc     4140

cttgtccctt tgacaataag gttaattgat agacccacca cctcttgcac tctcgctttt     4200

ggagcaagtt gcattaacta ttttgagtct ctatattgtc caagaaaagt agaaataata     4260

aatttacttt ccctttttct atcaccttat gtcctctacc attttctcct tcctcccttc     4320

ccttattttc tccttttcgt accctgtgtc ctccctgatt ttcctttcgt ttcttcttta     4380

ttttatccca ttctctgtta cttgactcag tgctcccttc ctctcctctc cttctagtgg     4440

atgcatgcag cctttttttc aatttttatt taaattgcaa aatttttact cagatttttt     4500

ttcctcttcc ctaattgcta agatttaagg acgttcttta ttatgaaact ttatcacatt     4560

cgaaatgttt gtttacagtg ggattttagg ggggattgtg tttaaatcaa atatatgtat     4620

tttaaaaata atgacatgct caaccttcct catcatggag taagaaaatt ctacatgatt     4680

aaagaatcca tgtaagtcta attttaaatt cctagtaact agagaaaaga cttatttata     4740

taaaatgaag tatttatgaa ctgtgataaa gcatcaaatc ttgatgaagg attgtagatt     4800

tttgcttttt ctttttgttt ttaaaactta ttccaattgc taaattggta gtttttcagt     4860

ctttataaat acaggattaa aaatatatat acagttatat gaaatgttta ttttctatgt     4920

gtgtgcatat agttcaatat tatgcaataa atttggtgtt ttaacttaaa acta           4974


<210> 2585
<211> 567
<212> DNA
<213> Homo sapiens

<400> 2585
gactcacgcc ttcgccgtag catctttcgc agcggaccga agagaagaaa agtaggccag       60

agccgaactc tcttcctgcc aagatgtcta ttggtgtgcc gattaaagta ctgcatgagg      120

ccgagggcca cattgtgaca tgtgagacga acaccggtga ggtatatcgg gggaagctca      180

ttgaagcaga ggacaacatg aactgccaga tgtccaacat cacagtcaca tacagagatg      240

gccgagtggc acagctggag caggtataca tccgtggcag caaaatccgc tttctgattt      300

tgcctgacat gctgaagaac gcacccatgt taaagagcat gaaaaataaa aaccaaggct      360

caggggctgg ccgaggaaaa gctgctattc tcaaggccca aggttatctg agttcattgg      420

agtgggtgct tgtgcatata tgctaggtcc cagagaaaaa cctccatgct gggttgatag      480

cagcagctag gatcagttgc ccaagactct ggattctcga gatgaagacc gtcagcagag      540

gctgatctct cctgtgggct catgtcc                                          567


<210> 2586
<211> 1696
<212> DNA
<213> Homo sapiens

<400> 2586
agcgtcacgc agcgaggccg tgcgtgcgcg ggcgtcaggg cggcgctgag ttgaggacgc       60

tggcggctcc gcgacgagct ttgttttttc ggttgggcat gctgcttacc gcaggatgat      120

ggaagcgacg gcccgtacaa agacagaagc gttggtttca ctgagtcagt gctgattctc      180

tcaaatagag cttgaaggat aaatcttcat ttttgtttca acaaaacttc gaaacaaaat      240

ggaagaaaat aatctacagt gcagtagtgt ggttgacggt aattttgaag aagttcccag      300

ggagacggca attcagttta aacctccact atacagacag cggtaccagt tcgttaaaaa      360

tttagtggat caacatgagc ctaagaaggt tgcagacctg ggatgtggtg atacttcact      420

cttaaggctg ctaaaagtca atccatgcat tgaattgctt gttggagtag atattaatga      480

ggataaatta cgatggagag gggattcgtt agctcctttc ctgggggatt ttctgaaacc      540

tcgggatctg aatttgacca tcacattgta tcatggctcc gttgtggaga gagactctcg      600

tttgcttgga tttgacttga taacgtgtat tgaattaata gaacatttgg attcaggtga      660

tctggccaga tttcctgaag tggtatttgg gtacctgtct ccatccatga ttgtcatcag      720

cacaccaaac tctgaattca atcccctgtt tccatcagtg accttaagag attcagatca      780

taaatttgag tggaccagaa tggagtttca gacctgggct ttatatgtgg caaatcgcta      840

tgattactct gtggagttta ctggtgtcgg ggaaccacca gctggagctg agaatgttgg      900

atactgtacc cagataggaa tcttccggaa aaatggagga aaggcaacag aatcatgtct      960

ttcagagcag catgatcagc atgtttataa agctgttttt accacctcat acccaagctt     1020

acagcaggaa aggttcttta aacttgtgtt ggttaatgag gtgtcccaac aagtggaaag     1080

cttaagagtg agccacctgc caaggcggaa agaacaggct ggggaacggg gtgataagcc     1140

caaagacatt ggtggctcaa aggcccctgt cccatgcttt ggaccagtct tcacagaggt     1200

tgagaaggcc aagatagaga actctcccac acccttctgt gttggagata aatttttcgt     1260

acctctgcag agactccttg cgtatcccaa gttgaaccgc ttatgtgcta atgaagagat     1320

gatgagatca gtcattgctg actcaattcc tctgagcagt gatggttctg cagtggtggc     1380

tgacctgcgt aattattttg atgaacagtt tgagttttga accatgttta tttcctgaaa     1440

tttcagggtc tcagcgatag ttgtgctcac ttagaattta gttttttttg tgtaatccta     1500

attcaagtaa tgtttttaaa gtttcactgc aaaagtctat gttccaagcc attggacaga     1560

cctgcttgag atatggccag actgcagtga gccctgagaa agatatgagg gtttaaaacg     1620

ggtgctttcc tttgattttg gacttttttg ttttctcaag aataaagaag ttggatgtgg     1680

taatatgtta attttg                                                     1696


<210> 2587
<211> 622
<212> DNA
<213> Homo sapiens

<400> 2587
ggcctgtgcg gctgcaggta gagtgtctta ggaacctagg aaataactcg gaacctgtaa       60

cgtcccactg gtttggacat attcctctcc tgatctggcc tcatctgttc cagggaggtg      120

ggattgaaca aagtcttgct ctgtcaccca ggctggagtg cagtggcgca atcacggctc      180

tctgcagcct cgacccccgg ggctcaagct attctcctgc ctcaccctcc tgagtagata      240

ggactacagg cacgtgcggc tatgcctagc taatttttta aatcttaagt agagacattg      300

tctcactgtg ttgcccagac tggtcttgaa ctcctaggtt gaagggatct tccagcctct      360

gcctcccgaa gtgctgtatt acagaacata tgcagtaatg tcacctcaaa agagagttaa      420

gaacgtccag gcacaaaaca ggacttcaca aggtagtagt agttttcaga ccacgctttc      480

agcctggaaa gtaaaacagg atccaagcaa ctcgaagaac atctcaaaac atggacaaaa      540

caatccagtg ggagattatg aacatgctga tgatcaagct gaagaagatg ctttgcaaat      600

ggcagtggga tattttgaga aa                                               622


<210> 2588
<211> 2033
<212> DNA
<213> Homo sapiens

<400> 2588
cgtgtatacc cgctcaacgc tgggacgtta cagccagggc caatgggcag agcgggactc       60

gaggccccgc ccccgccttg tggcgtcacg gggacgccgg gggcgcgcgg gctgcagggc      120

cgcgtaggtc cccgccccca gagtctggct ttccgcggct gcccgcctcg cgcgtcttcc      180

ctgcccgggt ctcctcgctg tcgccgccgc tgccacacca tggccttcgt caccaggcag      240

ttcatgcgtt ccgtgtcctc ctcgtccacc gcctcggcct cggccaagaa gataatcgtc      300

aagcacgtga cggtcatcgg cggcgggctg atgggcgccg gcattgccca ggttgctgca      360

gcaactggtc acacagtagt gttggtagac cagacagagg acatcctggc aaaatccaaa      420

aagggaattg aggaaagcct taggaaagtg gcaaagaaga agtttgcaga aaaccttaag      480

gccggcgatg aatttgtgga gaagaccctg agcaccatag cgaccagcac ggatgcagcc      540

tccgttgtcc acagcacaga cttggtggtg gaagccatcg tggagaatct gaaggtgaaa      600

aacgagctct tcaaaaggct ggacaagttt gctgctgaac atacaatctt tgccagcaac      660

acttcctcct tgcagattac aagcatagct aatgccacca ccagacaaga ccgattcgct      720

ggcctccatt tcttcaaccc agtgcctgtc atgaaacttg tggaggtcat taaaacacca      780

atgaccagcc agaagacatt tgaatctttg gtagacttta gcaaagccct aggaaagcat      840

cctgtttctt gcaaggacac tcctgggttt attgtgaacc gcctcctggt tccatacctc      900

atggaagcaa tcaggctgta tgaacgagac ttccaaacgt gtggtgattc taactcgggt      960

ttgggctttt ctttaaaagg tgacgcatcc aaagaagaca ttgacactgc tatgaaatta     1020

ggagccggtt accccatggg cccatttgag cttctagatt atgtcggact ggatactacg     1080

aagttcatcg tggatgggtg gcatgaaatg gatgcagaga acccattaca tcagcccagc     1140

ccatccttaa ataagctggt agcagagaac aagttcggca agaagactgg agaaggattt     1200

tacaaataca agtgatgtgc agcttctccg gctctgagaa gaacacctga gagcgctttc     1260

cagccagtgc cccgagtgcc tgtgggaatg ctctttggtc agacattccc tcacacagta     1320

cagtttaata aatgtgcatt ttgattgtaa tctatcgaag tgattattac accagttaca     1380

gcagtaatag attctccatt aagaaataat tccctttttt agtctgttca tttctgtgta     1440

ttttctaaac agctttacac ccttggtgcc ttggagcaaa catgtttttt gaaccttgtc     1500

atttttgtga agaattgcct agattccttc tctcatcaac gggaaagtac ttcctctgag     1560

agtgcgagtg caccatgctc actgttgctg cgtgggagag tcacaagcca ctggcaagca     1620

agtggtatag tctgtgaagc actgcagcga gcagcacctg gatcttgcct ttataagaac     1680

attttactac ctgcagcttt gagtcttgcc ctacattttg ggcatgacat aagatgtgtc     1740

tttattcagc tcgtcgtgaa gatgctgctg ctgaatgggt cagcatatct ctgtttgcat     1800

ggtttgcagg aggtcggttt tcatggtcat tcagttccac agatctgaat gattactgtc     1860

tgtctgtgtc ttttttccat gagaaatcac tgttgcaaat tgcctataaa ttgactctac     1920

taaaataaca atgtttcagt ctgaaaattt gaattgaaaa aaatgtataa tataaaattg     1980

taatacactc aaatgattat aaaagtaaaa gttggtaatt taggcagaag cta            2033


<210> 2589
<211> 2210
<212> DNA
<213> Homo sapiens

<400> 2589
aacgccagca ggcttccggg cccggagtgg gcggtgggac tcggggtccc agagagccgt       60

gcgcgggccg cgacgccgag caccgccctc gccgtcgcct ccgggctttc tccggtcgct      120

gccgccacca ccgttgcttc gcgggctggg aggcccgggg tccccgggcg aacagaggct      180

gcggtggact gacgccgcag gggcgagcta gccggctccg cgcctctccg cgggatccag      240

acgcctcctg gggctgctgg cggagggtct gaggcggcgc ggccatggct cacctccggg      300

gatttgccaa ccagcactct cgagtggacc ctgaggagct cttcaccaag ctcgaccgca      360

ttggcaaggg ctcgtttggg gaggtctaca agggcatcga taaccacaca aaggaggtgg      420

tggccatcaa gatcatcgac ctggaggagg ccgaggatga gatcgaggac atccagcagg      480

agatcactgt cctcagtcag tgcgacagcc cctacatcac ccgctacttt ggctcctacc      540

taaagagcac caagctatgg atcatcatgg agtacctggg cggcggctca gcactggact      600

tgcttaaacc aggtcccctg gaggagacat acattgccac gatcctgcgg gagattctga      660

agggcctgga ttatctgcac tccgaacgca agatccaccg agacatcaaa gctgccaacg      720

tgctactctc ggagcagggt gacgtgaagc tggcggactt tggggtagca gggcagctca      780

cagacacgca gattaagagg aacacattcg tgggcacccc cttctggatg gcacctgagg      840

tcatcaagca gtcggcctac gacttcaagg ctgacatctg gtccctgggg atcacagcca      900

tcgagctggc caagggggag cctccaaact ctgacctcca ccccatgcgc gtcctgttcc      960

tgattcccaa gaacagccca cccacactgg agggccagca cagcaagccc ttcaaggagt     1020

tcgtggaggc ctgcctcaac aaagaccccc gattccggcc cacggccaag gagctcctga     1080

agcacaagtt catcacacgc tacaccaaga agacctcctt cctcacggag ctcatcgacc     1140

gctataagcg ctggaagtca gaggggcatg gcgaggagtc cagctctgag gactctgaca     1200

ttgatggcga ggcggaggac ggggagcagg gccccatctg gacgttcccc cctaccatcc     1260

ggccgagtcc acacagcaag cttcacaagg ggacggccct gcacagttca cagaagcctg     1320

cggagcccgt caagaggcag ccgaggtccc agtgcctgtc cacgctggtc cggcccgtct     1380

tcggagagct caaagagaag cacaagcaga gcggcgggag cgtgggtgcg ctggaggagc     1440

tggagaacgc cttcagcctg gccgaggagt cctgccccgg catctcagac aagctgatgg     1500

tgcacctggt ggagcgagtg cagaggtttt cacacaacag aaaccacctg acatccaccc     1560

gctgaagcgc actgctgttc agatagggga cggaaggtcg tttgtttttg ttctgagctc     1620

cataagaact gtgctgactt ggaaggtgcc ctgtgctatg tcgtgcctgc agggacacgt     1680

cggatcccgt gggcctcaca tgccaggtca ccaggtcacc gtctccttcc acccctgcag     1740

tgtgctgttg tgcacgtcag ggacgctgtt ctctatgccc actgccctcc tccctctcct     1800

ggcccagcag tattgctcac gggggctcca gccgccggcg tggccctcat gagctacgcc     1860

tgggtcttct gcagactcat gcagccctat ggccgctcag accaaggcgc agagcaacta     1920

tcagggcagc tctgcctcct cctcccatga ggtggggaga ggcaacaggg cagcccccag     1980

aggagtgtcc tggccgctgt cctcccgggg cccatgatgg ccatagattt gccttgtggt     2040

gttggatcag gtactgtgtc tgctcataag tacttgtgtc atccagaatg ttttgttttt     2100

taagaaaatt gaattacttg tttcctgaaa tattctgagg ttaatatgtt agttttcata     2160

gaacattgag aggcccctgc cactttcaat aaagacctga cttggagaca                2210


<210> 2590
<211> 1751
<212> DNA
<213> Homo sapiens

<400> 2590
accgccgccg ccgccgctgg ccaaaaagcg gagcccaggg gaagcgtgtc ctgctcagac       60

cgccttcctt ctccattgcc acccgtgccg aacagccagg ctgcccaatt gcaactgtag      120

accaatgaac taatccatcg cccgcagccc gactctcagc agcggttcgt cccggtgccc      180

acccccgcga agcggagcgc ccgggcacct agcctccctg ccggccacct agcctccctg      240

ccggccacga tgccgaacgt gctgctgccg cccaaggaga gcaacctctt caaacgcatc      300

ttgaaatgtt atgaacagaa gcagtacaaa aatggcctca agttttgcaa gatgattctg      360

tcgaacccaa aatttgctga acatggagag actttggcta tgaaaggatt aacactgaac      420

tgtttaggaa aaaaagaaga agcttatgag tttgttcgta aaggacttcg taatgatgtc      480

aagagtcatg tctgttggca tgtatatgga ctcttgcagc gttctgataa aaaatatgat      540

gaagctataa aatgttaccg aaatgccctc aaattagata aagataacct gcaaattttg      600

agggatctct cactgttgca gatccaaatg agagaccttg aaggttaccg agagacaaga      660

taccagcttc ttcagttgcg ccccacacag cgtgcctcct ggattggata tgctattgca      720

taccatttgc tgaaagatta tgatatggcc ctaaaactgt tggaagaatt tagacaaact      780

cagcaagttc ctccaaacaa aatagattat gaatatagtg aattgatatt ataccagaat      840

caagtgatga gagaggcaga tctgttgcag gaatctttgg aacatataga aatgtatgag      900

aaacaaatat gtgataaact tttggtggaa gaaattaaag gggaaatact gttgaaattg      960

ggaagattaa aagaagccag tgaagtgttc aaaaacttga ttgatcgaaa tgcagaaaat     1020

tggtgttatt atgaaggctt ggaaaaagct ctacaaatta gcactttaga agagaggctt     1080

caaatttatg aagaaattag taagcagcac cccaaagcaa ttacacccag aagattacct     1140

ttgactcttg tcccaggtga aagatttaga gaactaatgg ataagttcct gagggttaac     1200

ttcagtaaag gctgcccacc cttgtttact actttgaaat ctttatatta caatacagaa     1260

aaggtttcta taatccagga acttgttact aattatgaag cctctcttaa aacgtgtgac     1320

ttttttagcc catatgagaa tggggagaag gaacccccga caacactact ctgggttcag     1380

tatttcctgg cacagcactt tgataaactt ggacagtatt ctttggcttt ggattatatt     1440

aatgctgcaa ttgctagtac tccaactcta atagaattat tctatatgaa agcaaaaatt     1500

tacaaggtaa aatctgaatc ctgttttttg agtagttgaa gaattcagct actttaagaa     1560

tccttggagt tttttctttg tggaaacaag ttctagggca ccctgataat ctttttctaa     1620

taatcctgtg tagtttcatg ttatattaat tgtataatca atgtgtaatt agatgtgtaa     1680

tcatttgagc tcttagtaaa tgtgaactgt aattttgatt tctaaataaa tttgacagaa     1740

atggtgacag a                                                          1751


<210> 2591
<211> 555
<212> DNA
<213> Homo sapiens

<400> 2591
atttactcca tcctttatag tgatgctaca ggacgaagag gaatggataa aaacattggc       60

gagcaactca ataaagcgta tgaagccttc cggcaggcat gcatggatag agattctgca      120

gtaaaagaat tacagcaaaa gactgagaac tatgagcaga gaatacgtga acaacaggaa      180

cagctgtcac ttcaacagac tattattgac aagctaaaat ctcagttact tcttgtgaat      240

tccactcaag ataacaatta tggctgtgtt cctctgcttg aagacagtga aacaagaaag      300

aataatttga ctcttgatca gccacaagat aaagtgattt caggaatagc aagagaaaaa      360

ctaccaaagg tagacattgc ttctgcagaa agcagcattt aaatgctgat gcgtgacata      420

gcttcctcat tttatttttc tgaagtgatc tgctggaatt ccaaacagaa gttccatata      480

tacaaatatg tggcttaaat atttctaaat agaagaacta ttttcaagta aaataaaggc      540

tgaggttttg tattt                                                       555


<210> 2592
<211> 4121
<212> DNA
<213> Homo sapiens

<400> 2592
gaatccccgg cggcggcgcg gggcggccgc ggaccgtgag tcagcattgg cggcggcccc       60

agcgcgtggc agccgtgcgc cgccaaggtg cgggtctcgt tactcggcgg tcaggagcgg      120

gccctccctt aggtgcgccc cccgccaggt tctgcgttag acctgcatct tagcaatgtg      180

aatattgcat ccctagagaa ggacctggaa gagcaagacg gccacgacct gggagcagca      240

ggtcccaggt cgctggccgg ctctgcacct gtcgccatcc ccggctccct gcccagagca      300

ccatcgctac actcgccatc ctctgcgtcc acctcgccgc tcggttcgct gtcccagccc      360

ctcccagggc cggtgggctc ctcagccatg acgcctcccc agcagccgcc acccctgcgt      420

tcagagccgg gcacactggg ctctgcagcc tcatcctaca gccccctagg tttgaacggt      480

gtccccggga gcatctggga ctttgtttcc ggcagcttct cccccagccc ctcccccatc      540

ctgagtgccg gccccccatc ctcttcgagt gcaagtccaa acggagctga gctggcccgg      600

gtcaggcggc agctggacga ggccaagagg aagatccggc agtgggagga gtcctggcag      660

caggtgaagc aggtctgcga tgcctggcag cgagaggcgc aggaggccaa ggagcgtgcc      720

cgtgtggccg atagcgaccg gcagctggcg ctgcagaaga aggaggaggt ggaggcacag      780

gtgaagcagc tgcaggagga gctggagggc ctgggcgtag cctccacact gccggggctg      840

cggggctgtg gggacatcgg caccattccc ctgccgaagc tgcactcgct gcagagtcag      900

ctgcgcctgg acctggaggc ggtggacggc gtgatcttcc agctccgcgc caagcagtgt      960

gtggcctgcc gggagcgggc ccacggtgct gtcctgcggc cctgtcagca ccacatcctc     1020

tgtgagccgt gtgcggccac cgcacctgag tgcccctact gcaagggcca gcccctgcag     1080

tggtgacctc agcggggaca gccacctcct gctgggcacc ctggctccag cgctcctcct     1140

gaccacggac atgtcgtcac tcgcttctgg tgccaccgac gtgaggaccg aggctgggag     1200

cccttcctgt tacacgttat catgaggctg ggagccccgc ctgcgcttgg cctgacagcc     1260

tttcctgtca cacgttgtca cctatctagt cctaccgacg gtttcaaggt attttcctca     1320

aaaaccttaa atgcaaaccc acagaacccg cctgcctgtc cctgaggggc ctggtgcctc     1380

cgggatccac gcggcgctgt gatcacagca gtttgtggtc ctgacactac tgtgactagg     1440

ccactgggag ctggggtctt tcaaagcact ttgtaaaccg aggaatttag ttagaggtta     1500

taaattgctc taagctgctt tctgtttttt tttaatatgc gataatatga agctttatat     1560

gtgtactgtg aacttaaata tttcatatca gtttattgtc aattcatagt atgctaaata     1620

tattagattt catattctga aactagtact tatgaaatga gtgtttatct agtagtaaga     1680

cctaggattt ttacattttc caattaagtg caaatagtat ttataagcag agtgattatg     1740

gattgagatg tttttaactt gatggaagga gctagttttc ctgagcctgt gtgtgcacca     1800

ggcactgggg ctgatgttcc agcctcgtgg cgtgggagca ggagagctcc gtcctgcatt     1860

tctgtggtcc gtggccgctg tttctgtgcg cctgcgcctc ggagagcaag tgaaggagca     1920

tcatgggttt tgttttctcc cttaaccctc tgaaagacag tttgatacta acaaaaaacg     1980

cagcagaggg gatccgacgt cagagctttt agaattactt ttttaagcag ctgtcttctg     2040

gctgggtgcg gtggctcatg cctgtgatcc cagcactttg ggaggcgggt ggatcaccta     2100

aggtcaggag ttcaagacca gcctggccaa catggtgcaa ccccgtctta gtaaaaatac     2160

aaaaattggc ctggcgtgag agcgggcacc tgtagtccca gctactcggg aggctgaggc     2220

aggagaatcg cttgaacctg ggaggcagag gttgcagtga gccgagatcg cgccaccgca     2280

ctccagcccg ggtgacagag cgagactctg gctcaaaaaa aaaaaaaaaa agctgttttc     2340

tgattactca gagctgtcct aggcaatggt gctttgtagc tccttggaga tgtcgctggg     2400

cgtcctggca ggggtcaggc agtgaactgg gagagtggtt gcctccccag cacccgtgac     2460

caccctggtc ctgctcgtgt gggagatgct cgggccgtgt gtgcgccagg gtccggggtg     2520

ccgggtgtat gtggcagtca cctgacccgc gctgccagtt atcatcggag ctcatccatg     2580

tggccagtga ggtcacagga gaggacccgg ccacagcctc tcagtggcct ggagcacacg     2640

ggggaagcga ccccccccag gtcccggctc tgctgtggtc ccctgtcccg tctgcccctg     2700

gagcgacagt gtggtttcgg ccgcagcaga aacgtgactg agaacgcatc cccgcgatga     2760

cctgaccctt ctgctcaggg ctgggactgt ccctaggagt tgagcaggaa caggcatctg     2820

tggtttacgg cgacctggct ctccgcgggc cacgtgggtg gtgagggcac acgagtggga     2880

agcggcaccg acgtgtttct ccccgaccgt ggctttgcca aagactttta atagcatttt     2940

ttaagtgcaa aacgtctagg taaaaatctt tatcatcagt gaccaaatta gaatgtattt     3000

aatatagtag gtggtttaag aactgtttta acgtaagaca aactgatagc aacattctgt     3060

tgttttaaag gaagtgggtc cgtgacattc tgcagctagt ccactactcc aaggtaacta     3120

tcgacttggt ttcagtgaat ctattttgtt tttaactaca gtgatttatt agctcagtat     3180

ctagaaatta cgtatatttt gtgctactgt catcgatgtg taaactctgt ttttatttgt     3240

atttatgcac ttggttccca tttggagcct ctggtctttt ctgggataag tggtgtctgc     3300

cgagacatct cccggttgtc agtggtcagg agcagctgag ctctagtctg ccagctgctc     3360

tgctctttct gggaaggagg tggcgcccgc ccctcagggt gtctccaggg ctcagcttcc     3420

ggggtggtag agctggggag ccccaggggt ggggggacag ctgggagatg gaggtggcac     3480

ctgctcccct agatcagtac tggctctgag gacaggtgag cagtgggaag accaaagaat     3540

ggctggcagc gctgccaggg ttggaaatgg gggcaagatc ctggggctgt gtgccctggg     3600

gcctccctca cctgtcttgg tggccatggc ctcagggatg gctcctaggt ggctgaggca     3660

cagcagtggc tggaaggtgc cccgtggagg ctgaggtgga ggcgcgccca gcagctcccc     3720

cctgtggcca tggcgggcac ggggcgtagg agctggctgg cggccggctc tgcatgttct     3780

tgttgcctgt cgtctgtaac tctagtgttc gacattcgcc gtgatacagt ggtgtcacga     3840

cgtgtgtaac tgtggtcagc agaccttgtt ccgcgtggac gcctcaagtg gattaatttc     3900

tggaagcctc aatctgtatg tttgagtatt tacatgagaa tgttatttga atggaatttt     3960

cttaacccag aaggtagtat ttataatcat ttacttgtag cgaactgttt aaagttaaca     4020

cttgtttaaa tttttttaca ctatagcatt tatgcaatgg tttacagaat tcatggagtt     4080

atttttatca gtatgggaat taattaaaac cttgaatctt t                         4121


<210> 2593
<211> 2110
<212> DNA
<213> Homo sapiens

<400> 2593
ctgtcccact gggcaggtgc ctctgacgga gaggaggcgt cgtcgggaag tatgtggccg       60

tggctgctct ggcatgatcc tgaagactgg cacgaagggg aatggagccg cacagagaat      120

ttcaggcatc agaggggaag cgcaggtttg tctacagatt ttgagcgttc gaagttgacc      180

cctgactaag tatactttgc tgctccctca gcctttgaaa aaatgtctgt cacatatgat      240

gattccgttg gagtagaagt gtccagcgac agcttctggg aggtcgggaa ctacaagcgg      300

actgtgaagc ggatcgacga tggccaccgc ctgtgcagcg acctcatgaa ctgcctgcat      360

gagcgggcgc gcatcgagaa ggcgtatgcg cagcagctca ctgagtgggc ccggcgctgg      420

aggcagctcg tggagaaagg gccccagtac gggaccgtgg agaaggcctg gatggccttc      480

atgtccgagg cagagagggt gagcgagctg cacctcgagg tgaaggcctc actgatgaac      540

gatgacttcg agaagatcaa gaactggcag aaggaagcct ttcacaagca gatgatgggc      600

ggcttcaagg agaccaagga agctgaggac ggctttcgga aggcacagaa gccctgggcc      660

aagaagctga aagaggtaga agcagcaaag aaagcccacc atgcagcgtg caaagaggag      720

aagctggcta tctcacgaga agccaacagc aaggcagacc catccctcaa ccctgaacag      780

ctcaagaaat tgcaagacaa aatagaaaag tgcaagcaag atgttcttaa gaccaaagag      840

aagtatgaga agtccctgaa ggaactcgac cagggcacac cccagtacat ggagaacatg      900

gagcaggtgt ttgagcagtg ccagcagttc gaggagaaac gccttcgctt cttccgggag      960

gttctgctgg aggttcagaa gcacctagac ctgtccaatg tggctggcta caaagccatt     1020

taccatgacc tggagcagag catcagagca gctgatgcag tggaggacct gaggtggttc     1080

cgagccaatc acgggccggg catggccatg aactggccgc agtttgagga gtggtccgca     1140

gacctgaatc gaaccctcag ccggagagag aagaagaagg ccactgacgg cgtcaccctg     1200

acgggcatca accagacagg cgaccagtct ctgccgagta agcccagcag cacccttaat     1260

gtcccgagca accccgccca gtctgcgcag tcacagtcca gctacaaccc cttcgaggat     1320

gaggacgaca cgggcagcac cgtcagtgag aaggacgaca ctaaggccaa aaatgtgagc     1380

agctacgaga agacccagag ctatcccacc gactggtcag acgatgagtc taacaacccc     1440

ttctcctcca cggatgccaa tggggactcg aatccattcg acgacgacgc cacctcgggg     1500

acggaagtgc gagtccgggc cctgtatgac tatgaggggc aggagcatga tgagctgagc     1560

ttcaaggctg gggatgagct gaccaagatg gaggacgagg atgagcaggg ctggtgcaag     1620

ggacgcttgg acaacgggca agttggccta tacccggcaa attatgtgga ggcgatccag     1680

tgatgagtcg gggacaggcc agcgggggga cggaggcggc gggcccagga gcctcagcca     1740

gccacgtggg catccactcc ttttcctgca agagatgatg gttccattgc tcttggcttc     1800

atggtgttcc tggaaggcag atgagctggt catttcgcct gggactcggc acctttccga     1860

gtgcagctgg agggatctga gcgcaggaag acgcagaaca acagaaatag ccgcccctcc     1920

ccgcccactg tgcctgttgg cctatcatag atctctatgt tcttgacttt gtctctcctt     1980

tccgagtcaa tggtgggtta cactgatctt gttccactga ttactctctc tgacgagtcc     2040

atcacctgca acttaaatga acaagcttac atcccatttt gagtgaagat tttgaggttt     2100

ttaatttaaa                                                            2110


<210> 2594
<211> 3581
<212> DNA
<213> Homo sapiens

<400> 2594
agaatgtcat cctcaaggga agtgcagaga gatttcttca gtcctcagct gagtataagc       60

tggcctcctg gagtctgtga acacaaacgt ccaatgtgag tgtgcctgtg caagcccctg      120

gctgtttata ctccggaggg tgtccccgtg cgtcatcggt ggagtggacc aaaactggtg      180

atctgtttgc cctgtgtgac cttgcccaga accctgctga ctgagagaac acatctgctg      240

gaagtcctct gggattcaag gtacagggag aactcgaggc ctcactgaaa cggaaagcaa      300

atacaaagaa actttatttt aaaaacatgt cttggtctcc caagaagagg gcaattggat      360

tgctcagcca gaatgaagag tagttttaca gaaaaaagag gacaatattg ggatcacctt      420

tgacctttcc atttggaaat aatattttct attgtgttat agaaaggtgg gaagctttca      480

tccagaacaa tgaatttcat aaaggacaat agccgagccc ttattcaaag aatgggaatg      540

actgttataa agcaaatcac agatgaccta tttgtatgga atgttctgaa tcgcgaagaa      600

gtaaacatca tttgctgcga gaaggtggag caggatgctg ctagagggat cattcacatg      660

attttgaaaa agggttcaga gtcctgtaac ctctttctta aatcccttaa ggagtggaac      720

tatcctctat ttcaggactt gaatggacaa agtctttttc atcagacatc agaaggagac      780

ttggacgatt tggctcagga tttaaaggac ttgtaccata ccccatcttt tctgaacttt      840

tatccccttg gtgaagatat tgacattatt tttaacttga aaagcacctt cacagaacct      900

gtcctgtgga ggaaggacca acaccatcac cgcgtggagc agctgaccct gaatggcctc      960

ctgcaggctc ttcagagccc ctgcatcatt gaaggggaat ctggcaaagg caagtccact     1020

ctgctgcagc gaattgccat gctctggggc tccggaaagt gcaaggctct gaccaagttc     1080

aaattcgtct tcttcctccg tctcagcagg gcccagggtg gactttttga aaccctctgt     1140

gatcaactcc tggatatacc tggcacaatc aggaagcaga cattcatggc catgctgctg     1200

aagctgcggc agagggttct tttccttctt gatggctaca atgaattcaa gccccagaac     1260

tgcccagaaa tcgaagccct gataaaggaa aaccaccgct tcaagaacat ggtcatcgtc     1320

accactacca ctgagtgcct gaggcacata cggcagtttg gtgccctgac tgctgaggtg     1380

ggggatatga cagaagacag cgcccaggct ctcatccgag aagtgctgat caaggagctt     1440

gctgaaggct tgttgctcca aattcagaaa tccaggtgct tgaggaatct catgaagacc     1500

cctctctttg tggtcatcac ttgtgcaatc cagatgggtg aaagtgagtt ccactctcac     1560

acacaaacaa cgctgttcca taccttctat gatctgttga tacagaaaaa caaacacaaa     1620

cataaaggtg tggctgcaag tgacttcatt cggagcctgg accactgtgg agacctagct     1680

ctggagggtg tgttctccca caagtttgat ttcgaactgc aggatgtgtc cagcgtgaat     1740

gaggatgtcc tgctgacaac tgggctcctc tgtaaatata cagctcaaag gttcaagcca     1800

aagtataaat tctttcacaa gtcattccag gagtacacag caggacgaag actcagcagt     1860

ttattgacgt ctcatgagcc agaggaggtg accaagggga atggttactt gcagaaaatg     1920

gtttccattt cggacattac atccacttat agcagcctgc tccggtacac ctgtgggtca     1980

tctgtggaag ccaccagggc tgttatgaag cacctcgcag cagtgtatca acacggctgc     2040

cttctcggac tttccatcgc caagaggcct ctctggagac aggaatcttt gcaaagtgtg     2100

aaaaacacca ctgagcaaga aattctgaaa gccataaaca tcaattcctt tgtagagtgt     2160

ggcatccatt tatatcaaga gagtacatcc aaatcagccc tgagccaaga atttgaagct     2220

ttctttcaag gtaaaagctt atatatcaac tcagggaaca tccccgatta cttatttgac     2280

ttctttgaac atttgcccaa ttgtgcaagt gccctggact tcattaaact ggacttttat     2340

gggggagcta tggcttcatg ggaaaaggct gcagaagaca caggtggaat ccacatggaa     2400

gaggccccag aaacctacat tcccagcagg gctgtatctt tgttcttcaa ctggaagcag     2460

gaattcagga ctctggaggt cacactccgg gatttcagca agttgaataa gcaagatatc     2520

agatatctgg ggaaaatatt cagctctgcc acaagcctca ggctgcaaat aaagagatgt     2580

gctggtgtgg ctggaagcct cagtttggtc ctcagcacct gtaagaacat ttattctctc     2640

atggtggaag ccagtcccct caccatagaa gatgagaggc acatcacatc tgtaacaaac     2700

ctgaaaacct tgagtattca tgacctacag aatcaacggc tgccgggtgg tctgactgac     2760

agcttgggta acttgaagaa ccttacaaag ctcataatgg ataacataaa gatgaatgaa     2820

gaagatgcta taaaactagc tgaaggcctg aaaaacctga agaagatgtg tttatttcat     2880

ttgacccact tgtctgacat tggagaggga atggattaca tagtcaagtc tctgtcaagt     2940

gaaccctgtg accttgaaga aattcaatta gtctcctgct gcttgtctgc aaatgcagtg     3000

aaaatcctag ctcagaatct tcacaatttg gtcaaactga gcattcttga tttatcagaa     3060

aattacctgg aaaaagatgg aaatgaagct cttcatgaac tgatcgacag gatgaacgtg     3120

ctagaacagc tcaccgcact gatgctgccc tggggctgtg acgtgcaagg cagcctgagc     3180

agcctgttga aacatttgga ggaggtccca caactcgtca agcttgggtt gaaaaactgg     3240

agactcacag atacagagat tagaatttta ggtgcatttt ttggaaagaa ccctctgaaa     3300

aacttccagc agttgaattt ggcgggaaat cgtgtgagca gtgatggatg gcttgccttc     3360

atgggtgtat ttgagaatct taagcaatta gtgttttttg actttagtac taaagaattt     3420

ctacctgatc cagcattagt cagaaaactt agccaagtgt tatccaagtt aacttttctg     3480

caagaagcta ggcttgttgg gtggcaattt gatgatgatg atctcagtgt tattacaggt     3540

gcttttaaac tagtaactgc ttaaataaag tgtactcgaa g                         3581


<210> 2595
<211> 2116
<212> DNA
<213> Homo sapiens

<400> 2595
gcgcgcccgc cgcccgggcg gaggagagga gcgcgcggcc gcgcagagca agctgagccg       60

agccgagccg agctgggggc gcagagcgcg ggaggcggcg gcggcgcgga gcccaggtgg      120

ctccgctgcc ggatgggagt gccccagtgt gctggatgaa gctggcgcat gcaccatgtc      180

atcatgtgtc tctagccagc ccagcagcaa ccgggccgcc ccccaggatg agctgggggg      240

caggggcagc agcagcagcg aaagccagaa gccctgtgag gccctgcggg gcctctcatc      300

cttgagcatc cacctgggca tggagtcctt cattgtggtc accgagtgtg agccgggctg      360

tgctgtggac ctcggcttgg cgcgggaccg gcccctggag gccgatggcc aagaggtccc      420

ccttgacacc tccgggtccc aggcccggcc ccacctctcc ggtcgcaagc tgtctctgca      480

agagcggtcc cagggtgggc tggcagccgg tggcagcctg gacatgaacg gacgctgcat      540

ctgcccgtcc ctgccctact cacccgtcag ctccccgcag tcctcgcctc ggctgccccg      600

gcggccgaca gtggagtctc accacgtctc catcacgggt atgcaggact gtgtgcagct      660

gaatcagtat accctgaagg atgaaattgg aaagggctcc tatggtgtcg tcaagttggc      720

ctacaatgaa aatgacaata cctactatgc aatgaaggtg ctgtccaaaa agaagctgat      780

ccggcaggcc ggctttccac gtcgccctcc accccgaggc acccggccag ctcctggagg      840

ctgcatccag cccaggggcc ccattgagca ggtgtaccag gaaattgcca tcctcaagaa      900

gctggaccac cccaatgtgg tgaagctggt ggaggtcctg gatgacccca atgaggacca      960

tctgtacatg gtgttcgaac tggtcaacca agggcccgtg atggaagtgc ccaccctcaa     1020

accactctct gaagaccagg cccgtttcta cttccaggat ctgatcaaag gcatcgagta     1080

cttacactac cagaagatca tccaccgtga catcaaacct tccaacctcc tggtcggaga     1140

agatgggcac atcaagatcg ctgactttgg tgtgagcaat gaattcaagg gcagtgacgc     1200

gctcctctcc aacaccgtgg gcacgcccgc cttcatggca cccgagtcgc tctctgagac     1260

ccgcaagatc ttctctggga aggccttgga tgtttgggcc atgggtgtga cactatactg     1320

ctttgtcttt ggccagtgcc cattcatgga cgagcggatc atgtgtttac acagtaagat     1380

caagagtcag gccctggaat ttccagacca gcccgacata gctgaggact tgaaggacct     1440

gatcacccgt atgctggaca agaaccccga gtcgaggatc gtggtgccgg aaatcaagct     1500

gcacccctgg gtcacgaggc atggggcgga gccgttgccg tcggaggatg agaactgcac     1560

gctggtcgaa gtgactgaag aggaggtcga gaactcagtc aaacacattc ccagcttggc     1620

aaccgtgatc ctggtgaaga ccatgatacg taaacgctcc tttgggaacc cattcgaggg     1680

cagccggcgg gaggaacgct cactgtcagc gcctggaaac ttgctcacca aaaaaccaac     1740

cagggaatgt gagtccctgt ctgagctcaa ggaagcaagg cagcgaagac aacctccagg     1800

gcaccgaccc gccccccgtg ggggaggagg aagtgctctt gtgagaggca gtccctgcgt     1860

ggaaagttgc tgggcccccg cccccggctc ccccgcacgc atgcatccac tgcggccgga     1920

ggaggccatg gagcccgagt agctgcctgg atcgctcgac ctcgcatgcg cgccgcgtcg     1980

cctctggggg gctgctgcac cgcgtttcca tagcagcatg tcctacggaa acccagcacg     2040

tgtgtagagc ctcgatcgtc atctctggtt atttgttttt tcctttgttg ttttaaaggg     2100

gacaaaaaaa aaaaaa                                                     2116


<210> 2596
<211> 793
<212> DNA
<213> Homo sapiens

<400> 2596
ggaacgggaa cgaccacagc caccgcaggg aaacaaccgg ggcccaggcc cagcagaaga       60

atagaaggaa ggtgatagga tgtgatgata gaatttgtga tagccaagca acaacttttc      120

ctaattcggc atgttaaaaa ataagggtca ctcatctaag aaagataact tggcagtcaa      180

tgcagttgct ttacaagatc acattttaca tgatcttcaa cttcgaaatc tttcagttgc      240

agatcattct aagacacaag tacaaaagaa agagaacaaa tctctaaaaa gagatacaaa      300

ggcaataata gatactggac ttaaaaaaac tacacagtgc cccaaactag aagactcaga      360

aaaagaatat gttcttgatc ccaaaccgcc gccgttgact ttggcacaga agttgggcct      420

cattgggcct ccaccacctc cactgtcatc agatgaatgg gagaaggtga aacagcgctc      480

tctcctgcaa ggggactccg tgcaaccatg ccccatctgt aaagaagaat tcgagcttcg      540

tcctcaggtg ctgctttcat gctcccatgt gttccacaaa gcatgtcttc aggcttttga      600

aaagttcaca aataagaaaa cctgtcctct ctgtagaaag aaccagtatc aaacccgagt      660

gatacacgat ggggcccgcc tgttcagaat caagtgtgtg accagaatcc aagcctactg      720

gagaggatgt gttgttagaa agtggtacag aaacctgagg aaaacagtac ctcccacaga      780

tgccaagtta aga                                                         793


<210> 2597
<211> 1141
<212> DNA
<213> Homo sapiens

<400> 2597
ggagttggcg cctagcgcgc agctccatcc ccgcctctgc agtggactcg gccgcagaat       60

cggggtcccg ggctcctgga acttgtcccg cccaggccgc ggcgaggagg tcactccagc      120

cgatctctgg accggattcg tcccattctc gtcctcatgg tggacaagaa actggtggtg      180

gttttcggag gcacaggtgc ccagggtggc tccgtggccc gcacactcct ggaagatggg      240

acattcaagg ttcgagtggt gacccgaaac cctaggaaga aggcagcaaa ggagctgagg      300

ctgcaaggtg cagaagtagt gcagggagac caagatgacc aggtcatcat ggagctggcc      360

ctgaatgggg cttacgccac cttcatcgtg accaattact gggagagctg cagccaggag      420

caggaggtca agcaggggaa gctgctcgct gatctggcca ggcgcctggg cctccactat      480

gtggtctaca gcggcctgga gaacatcaag aagctgacgg cagggagatt ggccgccgcg      540

cactttgacg gcaaagggga ggtggaggaa tatttccggg acattggcgt tcccatgacc      600

agtgtgcggc tgccctgcta ttttgagaac ctcctctccc acttcttgcc ccagaaagcc      660

ccagacggaa agagctactt gctgagcttg cccacaggtg acgttcccat ggatggcatg      720

tccgtgtctg acctgggtcc tgtggtgctc agccttttga agatgccaga aaaatacgtc      780

ggccagaaca tcgggctgag cacttgcagg cacacggccg aggagtacgc tgccctgctc      840

accaagcaca cccgcaaggt cgtgcacgat gccaagatga ctcctgagga ctacgaaaag      900

cttggctttc ccggtgcccg ggacctggcc aacatgttcc gtttctatgc cctgagaccc      960

gaccgtgaca tcgagctgac cctgagactc aaccccaagg ccctgacgct ggaccagtgg     1020

ctggaacagc acaaagggga cttcaacctg ctgtgacctg cccgcctcgc ggccccttgt     1080

ggggatcggg ggcaccagag gggcagaggc accaacatct gaataaagcc attgttctcc     1140

c                                                                     1141


<210> 2598
<211> 2654
<212> DNA
<213> Homo sapiens

<400> 2598
gcggcggctg ctttggcggc ggttggtggc cgtgcgggcg gggagggagg gggaggagag       60

aagaggaggt ggagaaggct tgggctcgcg ccgctgaagt cggcttaccc gctggccgcc      120

tcctgacaag cgggagggat ccgcggtgga cccagggaag cggaggagcc tggcggccac      180

cccctcttcc tcacttccct gtactctcat cgctctcggc ctccgacacg aaaaggaagc      240

aaatgagctg atggaagatc tgtttgaaac tttccaagat gagatgggat tctccaacat      300

ggaagatgat ggcccagaag aggaggagcg tgtggctgag cctcaagcta actttaacac      360

ccctcaagct ctacggtttg aggaactact ggccaaccta ctaaatgaac aacatcagat      420

agcgaaggaa ctatttgaac agctgaagat gaagaaacct tcagccaaac agcagaagga      480

ggtagagaag gttaaacccc agtgtaagga agttcatcag accctgattc tggacccagc      540

acaaaggaag agactccagc agcagatgca gcagcatgtt cagctcttga cacaaatcca      600

ccttcttgcc acctgcaacc ccaatctcaa tccggaggcc agtagcacca ggatatgtct      660

taaagagctg ggaacctttg ctcaaagctc catcgccctt caccatcagt acaaccccaa      720

gtttcagacc ctgttccaac cctgtaactt gatgggagct atgcagctga ttgaagactt      780

cagcacacat gtcagcattg actgcagccc tcataaaact gtcaagaaga ctgccaatga      840

atttccctgt ttgccaaagc aagtggcttg gatcctggcc acaagcaagg ttttcatgta      900

tccagagtta cttccagtgt gttccctgaa ggcaaagaat ccccaggata agatcctctt      960

caccaaggct gaggacaaca agtaccttct aacctgcaag actgcccgcc aactgacagt     1020

gagaatcaag aacctcaaca tgaacagagc tcctgacaac atcattaaat tttataagaa     1080

gaccaaacag ctgccagtcc taggaaaatg ctgtgaagag atccagccac atcagtggaa     1140

gccacctata gagagagaag aacaccggct cccattctgg ttaaaggcca gtctgccatc     1200

catccaggaa gaactgcggc acatggctga tggtgctaga gaggtaggaa atatgactgg     1260

aaccactgag atcaactcag atcaaggcct agaaaaagac aactcagagt tggggagtga     1320

aactcggtac ccactgctat tgcctaaggg tgtagtcctg aaactgaagc cagttgccga     1380

ccgtttcccc aagaaggctt ggagacagaa gcgttcatca gtcctgaaac ccctccttat     1440

ccaacccagc ccctctctcc agcccagctt caaccctggg aaaacaccag cccaatcaac     1500

tcattcagaa gcccctccga gcaaaatggt gctccggatt cctcacccaa tacagccagc     1560

cactgtttta cagacagttc caggtgtccc tccactgggg gtcagtggag gtgagagttt     1620

tgagtctcct gcagcactgc ctgctatgcc ccctgaggcc aggacaagct tccctctgtc     1680

tgagtcccag actttgctct cttctgcccc tgtgcccaag gtaatgatgc cctcccctgc     1740

ctcttccatg tttcgaaagc catatgtgag acggagaccc tcaaaaagaa ggggagccag     1800

ggcctttcgc tgtatcaaac ctgcccctgt tatccaccct gcatctgtta tcttcactgt     1860

tcctgctacc actgtgaaga ttgtgagcct tggcggtggc tgtaacatga tccagcctgt     1920

caatgcggct gtggcccaga gtccccagac tattcccatc gccaccctct tggttaaccc     1980

tacttccttc ccctgtccat tgaaccagcc ccttgtggcc tcctctgtct cacccttaat     2040

tgtttctggc aattctgtga atcttcctat accatccacc cctgaagata aggcccacat     2100

gaatgtggac attgcttgtg ctgtggctga tggggaaaat gcctttcagg gcctagaacc     2160

caaattagag ccccaggaac tatctcctct ctctgctact gttttcccca aagtggaaca     2220

tagcccaggg cctccaccag tcgataaaca gtgccaagaa ggattgtcag agaacagtgc     2280

ctatcgctgg accgttgtga aaacagagga gggaaggcaa gctctggagc cgctccctca     2340

gggcatccag gagtctctaa acaactcttc ccctggggat ttagaggaag ttgtcaagat     2400

ggaacctgaa gatgctacag aggaaatcag tggatttctt tgagctagga gaataagagt     2460

ctggagactg ggagccttca cttcggcctc cgattggtgg cgcatagggt gtaaccaata     2520

ggaaacccct aaagggtact taaaccccag attttgcaac tggggctctt gagcagcttg     2580

ctttagcctg ctcccactct gtggaatata cttttgcttc aataaatctg tgcttttatt     2640

gcttcattgt ttca                                                       2654


<210> 2599
<211> 1693
<212> DNA
<213> Homo sapiens

<400> 2599
cgcgagcgcc aggcgtccgg ccgccgtggc tatgttcgtg tccgatttcc gcaaagagtt       60

ctacgaggtg gtccagagcc agagggtcct tctcttcgtg gcctcggacg tggatgctct      120

gtgtgcgtgc aagatccttc aggccttgtt ccagtgtgac cacgtgcaat atacgctggt      180

tccagtttct gggtggcaag aacttgaaac tgcatttctt gagcataaag aacagatcaa      240

attactcatt aaacaagatg atgaccttga agttcccgcc tatgaagaca tcttcaggga      300

tgaagaggag gatgaagagc attcaggaaa tgacagtgat gggtcagagc cttctgagaa      360

gcgcacacgg ttagaagagg agatagtgga gcaaaccatg cggaggaggc agcggcgaga      420

gtgggaggcc cggagaagag acatcctctt tgactacgag cagtatgaat atcatgggac      480

atcgtcagcc atggtgatgt ttgagctggc ttggatgctg tccaaggacc tgaatgacat      540

gctgtggtgg gccatcgttg gactaacaga ccagtgggtg caagacaaga tcactcaaat      600

gaaatacgtg actgatgttg gtgtcctgca gcgccacgtt tcccgccaca accaccggaa      660

cgaggatgag gagaacacac tctccgtgga ctgcacacgg atctcctttg agtatgacct      720

ccgcctggtg ctctaccagc actggtccct ccatgacagc ctgtgcaaca ccagctatac      780

cgcagccagg ttcaagctgt ggtctgtgca tggacagaag cggctccagg agttccttgc      840

agacatgggt cttcccctga agcaggtgaa gcagaagttc caggccatgg acatctcctt      900

gaaggagaat ttgcgggaaa tgattgaaga gtctgcaaat aaatttggga tgaaggacat      960

gcgcgtgcag actttcagca ttcattttgg gttcaagcac aagtttctgg ccagcgacgt     1020

ggtctttgcc accatgtctt tgatggagag ccccgagaag gatggctcag ggacagatca     1080

cttcatccag gctctggaca gcctctccag gagtaacctg gacaagctgt accatggcct     1140

ggaactcgcc aagaagcagc tgcgagccac ccagcagacc attgccagct gcctttgcac     1200

caacctcgtc atctcccagg ggcctttcct gtactgctct ctcatggagg gcactccaga     1260

tgtcatgctg ttctctaggc cggcatccct aagcctgctc agcaaacacc tgctcaagtc     1320

ctttgtgtgt tcgacaaaga accggcgctg caaactgctg cccctggtga tggctgcccc     1380

cctgagcatg gagcatggca cagtgaccgt ggtgggcatc cccccagaga ccgacagctc     1440

ggacaggaag aacttttttg ggagggcgtt tgagaaggca gcggaaagca ccagctcccg     1500

gatgctgcac aaccattttg acctctcagt aattgagctg aaagctgagg atcggagcaa     1560

gtttctggac gcacttattt ccctcctgtc ctaggaattt gattcttcca gaatgacctt     1620

cttatttatg taactggctt tcatttagat tgtaagttat ggacatgatt tgagatgtag     1680

aagccatttt tta                                                        1693


<210> 2600
<211> 1306
<212> DNA
<213> Homo sapiens

<400> 2600
gtctctcggc tgcagccctg gtgcgacccg gcccgttgcc gtagagatgg gcagggctgg       60

atggagtggg gtgcggtgag ctgagctgac cctgcttcgc cacggggact gcagtgaccc      120

cggcttgccg gcagggcggg taacaggttg agccagggtg gggctgctca ggggcgtgga      180

gccgaggcca ggatttctct gaagacccgg cacaggctat tcctttctgc gacgagccca      240

ttgctatgga aaccaaagcg ttaggccagc ggggattgag gctgcgggat catgacgggt      300

ctctctcccg aagaaccttg cctaaggctt ccccaagcgg ctacttcctg agcgaacccg      360

cccacccgcc tgaaggagag agttttccat ggacacagcc tagcagaaag acgcagcctt      420

cgtgcttcgc tgactgctga ccactgaccc accgccttga tgacagcacc ctcgtgtgcc      480

ttcccagttc agttccggca gccctcagtc agcggcctct cgcagataac caaaagcctg      540

tatatcagca atggtgtggc cgccaacaac aagctcatgc tgtctagcaa ccagatcacc      600

atggtcatca atgtctcagt ggaggtagtg aacaccttgt atgaggatat ccagtacatg      660

caggtacctg tggctgactc ccctaactca cgtctctgtg acttctttga ccctattgct      720

gaccatatcc acagcgtgga gatgaagcag ggccgtactt tgctgcactg tgctgctggt      780

gtgagccgct cagctgccct gtgcctcgcc tacctcatga agtaccacgc catgtccctg      840

ctggacgccc acacgtggac caagtcatgc cggcccatca tccgacccaa cagcggcttt      900

tgggagcagc tcatccacta tgagttccaa ttgtttggca agaacactgt gcacatggtc      960

agttccccag tgggaatgat ccctgacatc tatgagaagg aagtccgttt gatgattcca     1020

ctgtgagcca tcccacgagc ccctgcattg gagtcagagc ccctgccctt gatggatcag     1080

ctggcaccac ccagattgat aaactggctc gtctgatctt gtggccccca cccaggaact     1140

gactgggcac tagaaaacag cttcaacatc ctgtgatttc atccctgacc aatcagcact     1200

cctgtctcac tggcttcccc caacccacca agttgtcctt aaaactctgc tccctgaatg     1260

gtcggggaga ctgatttcag taatagtaaa actctggtct cctgca                    1306


<210> 2601
<211> 2878
<212> DNA
<213> Homo sapiens

<400> 2601
gcgccggcac acctattggc ccccgcggcg tcccgtcgcc gcgtcgcgtt gctggcccgt       60

cggagcgacg ccgctcgggt cagtcggcgg ccggactggg aagatggacg cagctactct      120

gacctacgac actctccggt ttgctgagtt tgaagatttt cctgagacct cagagcccgt      180

ttggatactg ggtagaaaat acagcatttt cacagaaaag gacgagatct tgtctgatgt      240

ggcatctaga ctttggttta catacaggaa aaactttcca gccattgggg ggacaggccc      300

cacctcggac acaggctggg gctgcatgct gcggtgtgga cagatgatct ttgcccaagc      360

cctggtgtgc cggcacctag gccgagattg gaggtggaca caaaggaaga ggcagccaga      420

cagctacttc agcgtcctca acgcattcat cgacaggaag gacagttact actccattca      480

ccagatagcg caaatgggag ttggcgaagg caagtccata ggccagtggt acgggcccaa      540

cactgtcgcc caggtcctga agaagcttgc tgtcttcgat acgtggagct ccttggcggt      600

ccacattgca atggacaaca ctgttgtgat ggaggaaatc agaaggttgt gcaggaccag      660

cgttccctgt gcaggcgcca ctgcgtttcc tgcagattcc gaccggcact gcaacggatt      720

ccctgccgga gctgaggtca ccaacaggcc gtcgccatgg agacccctgg tacttctcat      780

tcccctgcgc ctggggctca cggacatcaa cgaggcctac gtggagacgc tgaagcactg      840

cttcatgatg ccccagtccc tgggcgtcat cggagggaag cccaacagcg cccactactt      900

catcggctac gttggtgagg agctcatcta cctggacccc cacaccacgc agccagccgt      960

ggagcccact gatggctgct tcatcccgga cgagagcttc cactgccagc acccgccgtg     1020

ccgcatgagc atcgcggagc ttgacccgtc catcgctgtg gggtttttct gtaagactga     1080

agatgacttc aatgattggt gccagcaagt caaaaagctg tctctgcttg gaggtgccct     1140

gcccatgttt gagctggtgg agctgcagcc ttcacatctg gcctgccccg acgtcctgaa     1200

cctgtcccta gattcttctg atgtagagcg actggaaaga ttcttcgact cagaagatga     1260

agactttgaa atcctgtccc tttgaaaatc ctggggtcgg gggtggcacc tgtgagagcc     1320

tggggctcct ggtgccgctg cgtttcatcc atcccgcccg ctcgcctgcc gagggctgcg     1380

ccccgtgctg cctcccccca gagggccacc cgctgtgctc gtggactgag gctgcgctgc     1440

ccgggaggcc ttactgcttg gtgtcagact gcccagctca gagtgcccgt cagggcctgt     1500

gcatccgcac gcggagccgt ctgttaggag cttccagagt gttctctcga cactgccagc     1560

cccgtgttag cacctgggcc tcagtcccac ttgctcccag gcgccggttc tgtggttggt     1620

ttggaattaa agtcctgttt gaagttgtca gacacagaca tgaatttctg ggcgctccct     1680

gagtcagagt ctcagaagac ctgtgcaggc tggcgtgaga ggagcggcag ccacactgcg     1740

gccccacgcc caaggactgg gctgctctcg aggggggcgc gcccaccgct gtgtcctctc     1800

tgcccagcct ggcttaccaa gggctacctc agtgggagat gaggttggag gaacgaaggc     1860

gaggttcctc cttgctttgg ggagaaaagt attcaggaag tgggtgtgtg ggaaacctga     1920

agatggcgtg cacaggacac agcgtgggcg gcctgggcag aagggcggct ggctgtcctg     1980

gagctgctgc tggagcctgc cctcagagtg tccctttcca gtgctgtggc attctgtggc     2040

agcttcccca ggtgtggtga cggggggggg gcggggcctc cacctgtgac agccaggctt     2100

gagggtggac ggcgtgcctc tcccaggagc cttccccatg tccttgcctt gctgagaatt     2160

gccctcccat gccgctgagg tgttaggtgg tttagggcca aaaggggaaa accacttgag     2220

tcttgtggtg tgtggtgggc agacaccaca gggtggcatc acctggtggc atttccagaa     2280

cctcagcccc gattccagca cccaccaccg cctgaccctg tgtaacctgc tgtcccgggt     2340

cccagagtgc actctgcccc gctgctctgc tgcctgtcct gggaaagtat ctttgcccca     2400

ctaggaaatg taaacaggag ggcttgggga gcgtgggcac ttttctcatg agcagctact     2460

gcggcgttgg caggactcgc tgctgctgct gctgcttgtg taggtcgggg agccagagat     2520

ccccgaggac gcgcgccgga cagtcggcac tgaccggccc acctggtagc agaggacacc     2580

cccagccccc caagcattga agacatagtg tatttcctcg tatcctttct cccttgggtg     2640

tagttggggt ggggaagcag ggaaggctgg tgcgatctcc attccttggg ctccacgtcc     2700

gagttcatgg tgcgccgctg tgctgggagc tgcagtggta atgtgtggga caccttgacc     2760

aaaggggagc tttgtctcgt gtgttttgaa aaaggcttaa tgaagagaat gttgttcatt     2820

cttagtagta tagtttgcaa ttcttaatgg caaataataa gtttcagtag aaaacaaa       2878


<210> 2602
<211> 1557
<212> DNA
<213> Homo sapiens

<400> 2602
gaccagaaaa gccagactaa tcaggacgag ttcgggcgtg gaattgggcc tgaagccctc       60

atgcccagcc aggcctgaat gccccagacc ccaccgtcac ccccgtggcc tggatggagc      120

aggggacggc cggcgaaggc gcggggtgga aggggagcgg cgacgaaggc gcgaggagct      180

gactgggaat ccccaagcta cccgaggcaa gacactgaac ttgagtcgca cttttcatgc      240

ctgtagaaat gagaatgaca gctgtgataa aaaaaaaatt catctgggcg gtatctggaa      300

cttggcggtg gatgaggagg gctgctcgct ggctgcggct gaggctcggt caccgtgtag      360

agaggcccag ggagagctgc ttcactcaag tcctgtcaag tcaaggcagc cgggatttgt      420

ccacatctaa ggcgaaagag aatgaaagac gtagataacc tcaaaagtat aaaagaagaa      480

tgggtttgtg aaacaggatc tgataatcaa cctcttggta ataatcaaca atcaaattgt      540

gaatattttg ttgatagcct ttttgaggaa gctcagaagg ttagttccaa atgtgtgtct      600

cccgctgaac agaagaaaca ggtagatgta aatataaaat tatggaaaaa cggattcacc      660

gtcaacgacg atttcagaag ttattccgat ggtgccagtc agcagttttt gaactccatc      720

aaaaaggggg aattaccttc agaattacag ggaatttttg ataaagaaga ggtggacgtt      780

aaagttgaag acaagaaaaa tgaaatatgt ttgtctacga agcctgtgtt ccagcccttt      840

tcaggacagg gtcacagact aggaagtgcc acaccaaaaa ttgtttctaa agcaaagaat      900

attgaagttg aaaataaaaa taatttgtct gctgttccac tgaacaactt ggaacccatt      960

actaatatac agatctggtt ggccaatgga aaaaggattg tccagaaatt taacattact     1020

catagagtaa gccatatcaa agacttcatt gaaaaatacc aaggatctca aagaagtcct     1080

ccgttttccc tggcaacagc tcttcctgtc ctcaggttgc tagatgagac actcacactg     1140

gaagaagcag atttacagaa tgctgtcatc attcagagac tccaaaaaac tgcatctttt     1200

agagaacttt cagagcactg atttttgata gactaagtgg aaaatttgca gagaaatgat     1260

ggttgtaagt ggacatgcaa accaaaattg gggattggag aagtcagact cactagactt     1320

ttggttcgag tactattgaa ctctctcctg atgagaagat gtttagataa gtacaagtta     1380

agaaagtagc atatgactgg aaactatatt cagtgcactt tctccaaaag actacccaga     1440

aaaatagact tattttcaaa taccagttat caagatatat taaatagctg tattgtttag     1500

aatcttaata tggtataaat tagcatatgt attcacaata ttcattcaga catcatt        1557


<210> 2603
<211> 2958
<212> DNA
<213> Homo sapiens

<400> 2603
gggcccgcgg aggaaagata ctggggagtg ggagccgcgg ggttcagagc gatgattccc       60

ccacaggagg catccgctcg acggcgggag attgaggaca agctgaagca ggaggaggag      120

actctgtcct tcatccgaga cagcctggag aagagcgacc agctcactaa gaacatggtg      180

tctatcttat catcctttga gagccgcctt atgaagctgg agaactccat catccctgtg      240

cacaagcaga cggagaatct gcagcggctg caggagaatg ttgagaagac gctgtcctgc      300

ctggaccatg tcatcagcta ctaccatgtg gccagtgaca ctgagaagat catcagagag      360

ggccccacag gtaggctgga agagtacctg ggaagcatgg ccaagattca gaaggcagtg      420

gagtatttcc aggacaacag cccagacagc ccggaactca acaaagtgaa actgctcttt      480

gagcgcggga aggaggccct ggagtccgaa tttcgcagcc tgatgacgcg gcacagtaag      540

gtcgtctcgc ccgtgctcat cttggatctg atcagtggtg acgatgatct ggaggcccag      600

gaggacgtga ccctggagca cctgcccgag agcgtgctcc aggatgtcat tcgcatctcc      660

cgctggctgg tggaatatgg ccgcaaccaa gatttcatga acgtctacta ccagatacgc      720

tccagccagc tggaccgctc catcaaagga ctgaaggagc atttccataa gagcagttct      780

tcctctgggg ttccctactc ccctgctatc cccaacaaga ggaaagacac acctaccaag      840

aagccagtca agcggccagg tgagccccca tcctggccca tctctgcaac agccagaggc      900

tgactgggac tgtactgctt tagtccaatc tagcgttcgc agcgtcaggc ccctccagag      960

cttgtcgtcg tggtaacccc gactgtaggt acacaggaca gaaagcaagt gtctacccac     1020

ccagtgaagc cccccaagag caagactctt ccttccagct agcagagcct ggggttacac     1080

agcttctttg gagtagggga gtaacacagg tgctcagcga atcccgcctg aggcagagcc     1140

cctgcctagg cctcctccct cacacacacg tcgccctgtc agaaggccag gcacactact     1200

gcagccagga tgctgggata gcaaggggat aggtgctcca accttcacct tccagaaagg     1260

cagggtgatc tgaagtgacg tgtagctgag agctggatgg ggagaatttc actttcccag     1320

ttgatccaga aaggaaagaa accccagagc atcctctcgg aagaacttaa actggctttg     1380

ggctccagtg cgagcgagtg acttgtggaa aggggcacca tgatgagagg ccggggccgg     1440

tgggtgttgc tgtcctgggt gaacatctcg tcatctgtct gttctttctc cccggcatca     1500

tatcccttat agtctgtgct ccaggtaaac agtgtctctg ccagccacag cttggcaagc     1560

ccggctatgt ctggccactg agagatgctg cccgcagctc gatgatgtgc tgggatgttc     1620

tggggtgggg ctgctgagat tgcactgaaa aagaaagctg gagaagccgg ggctgctccc     1680

acccaggctg gccccctgtc cagctgctgc tgtgggcaca tgccctagtt gtggcctgtg     1740

gcacctgctt atgacaacaa gctttgggta gagcttactt acacccttgg tttctccagt     1800

ccctgcctgc tcatgcccct cagagagtga ggtgtctgtt ccacaagagc acccgctccc     1860

ctgcaggcct ttgtttaggg tttggagaaa caggcagagc aggggctgcc ctcagggagt     1920

agagcattag ggagctggtg cctggggcct tctccctcca gtgtggaaat cctgcccacc     1980

agccaaaacc tgctgcaaat ggggactgcc agcccagcct gtgggcgcag ctgcctgcac     2040

agtggatgga gcagctctgt gccttctgtg tggtggggag tggctgtctc tatgaggctg     2100

ctaggatgct tgggccccag ccagtctgtg cttgcttcct cttctgcctg gctccctgac     2160

aggtccccca gaagccccag agccctattt gcactgcctt aagagtgccc gctggccatg     2220

cagctacctg gcctttcagg caggagggat ctgatctcag gtggctcaca gtggaccaca     2280

tccatccttg ggccagagac actagaggaa aactccagct gtggggtttc agagttgtca     2340

ggaactggtg ggctcaggac cgatgtcagg ctctagggag tcaggctctg gggatgtcgg     2400

ttcccacttc tgaggagagg gacagggagg cctcccaggt ggtgaagcac cgacctcagc     2460

atccctggag gcaattggga gcctgacggg tttggcggct gctagatcca catcggcgac     2520

ccacatcctg ccggcgtgca cctgcgtctg tgtctgctcc tggtgggttg tggggcagga     2580

atcagattca ctcattagta agccgcactc gctgaagggg agagcatgag caagggagac     2640

gtgagccagg ccttggttat taggagctaa ttatgggcca agtatggtgg ctcacgcctg     2700

taatcctagc acttcgggag gccgaggcgg gcggatcacc tgaggtcagg agttcgagac     2760

cagcctggcc aacatggtga aaccctgtct ctactaaaaa tagaaaaaaa attagttggg     2820

tgtggtgacg cacgcctata atcccagcta cctgggaggc tgaggcagga gaatcacttg     2880

aacccaggag gcagaggttg cagtgagccg aggtcgtgcc accgtactcc agcctgggcg     2940

acagagtgag actgtctc                                                   2958


<210> 2604
<211> 2183
<212> DNA
<213> Homo sapiens

<400> 2604
ggggagactc caaacagtga gcctagagct ggagactagc gttaaccggc ggggcggccg       60

gttttatgaa tgaagctatg gctacagatt ccccaagaag acccagtcgt tgtactggtg      120

gagttgtggt tcgcccccag gctgtcacag agcagtccta catggaaagt gttgtgactt      180

ttctgcagga tgttgtgcca caggcttaca gtggaacacc tctaacagaa gaaaaggaga      240

aaatagtctg ggtcagattt gaaaatgcag atttaaatga tacatcaaga aatctggaat      300

ttcatgaaat acatagtact gggaatgaac cgcctttgtt gattatgatt ggctacagtg      360

atggaatgca ggtctggagc atccctatca gtggtgaagc acaagagctc ttctctgttc      420

gacatggccc aattcgagcg gctagaatct tgcctgctcc acagtttggt gctcaaaaat      480

gtgataactt tgctgaaaaa agacccctcc ttggtgtttg taagagcatt ggatcttctg      540

gcacaagccc accgtactgt tgtgtggatc tgtattcact tcgtactggg gagatggtca      600

agtccattca atttaagaca cctatttatg atctccattg caataaacgg atccttgtcg      660

tagtcttgca ggagaaaatt gctgcctttg atagctgtac tttcacgaag aaattctttg      720

ttacaagctg ctatccatgt ccagggccaa acatgaatcc tattgctctt gggagccgct      780

ggcttgctta tgcagaaaac aagttgattc gatgtcatca gtcccgtggt ggagcctgtg      840

gagacaacat tcagtcttat actgccacag tcattagtgc tgctaaaaca ttgaaaagtg      900

gcctgacaat ggtagggaaa gtggtgactc agctgacagg cacactgcct tcaggtgtga      960

cagaagatga tgttgccatc cacagtaatt cacggcggag tcctttggtc ccaggcatca     1020

tcacagttat tgacaccgaa accgttggag agggccaggt gcttgtgagt gaggattctg     1080

acagtgatgg cattgtggcc cacttccctg cccatgagaa gccagtgtgc tgcatggctt     1140

ttaatacaag tggaatgctt ctagtcacaa cagacaccct tggccatgac tttcatgtct     1200

tccaaattct gactcatcct tggtcctcat cacaatgtgc tgtccaccat ctgtatactc     1260

ttcacagggg agaaactgaa gccaaagtac aggacatctg cttcagccat gactgtcgct     1320

gggttgtggt cagtactctc cggggtactt cccacgtttt ccccatcaac ccttatggtg     1380

gccagccttg tgttcgtaca catatgtcac cacgagtagt gaatcgcatg agccgtttcc     1440

agaaaagtgc tggactggaa gagattgaac aagaactgac gtctaagcaa ggaggtcgct     1500

gtagccctgt tccaggtcta tcaagcagcc cttctgggtc acccttgcat gggaaactga     1560

acagccaaga ctcctataac aattttacca acaacaaccc tggcaaccct cggctctctc     1620

ctcttcccag cttgatggta gtgatgcctc ttgcacaaat caagcagcca atgacattgg     1680

ggaccatcac caaacgaacc gggccttatc tctttggagc ggggtgtttt tccataaaag     1740

ccccatggag ctacataatg acaaaatata tattttacat aaaacctcct aacaaagtta     1800

aacctcctcc acaaatttca cccagcaaat cgatgggcgg agaattttgt gtggctgcta     1860

tcttcggaac atccaggtca tggtttgcaa ataatgcagg tctgaaaaga gaaaaagatc     1920

agtccaaaca agttgtagtt gagtccctgt acattatcag ttgctatggc accttagtgg     1980

aacacatgat ggagccgcga cccctcagca ctgcacccaa gattagtgac gacacaccac     2040

tggaaatgat gacatcgcct cgagccagct ggactctggt tagaacccct caatggaatg     2100

aattgcagcc accgtttaat gcaaaccacc ctctgctcct cgctgcagat gcagtacagt     2160

attatcagtt cctgcttgct ggc                                             2183


<210> 2605
<211> 2333
<212> DNA
<213> Homo sapiens

<400> 2605
agtccactgc tgggcctgga acacggagca gtggctgccc tgcgaggagg tcctagagca       60

gctccagcag gatggcggct ccagcgtctc taaggcctgc agggggtcca gccccatggg      120

gggcgcccta ggcctccgac agctccccat ctgtgctcct gcctgccggc catcctcagg      180

ccactcgcca tgggcggctg cttctccaaa cccaaaccag gcgctgcctt gcccacagtg      240

gagctcaaga tcgaggtggt gctgcctgag aaggagcgag gcaaggagga gctgtcggcc      300

agtgggaagg gcagcccccg ggcctaccag ggcaatggca cggcccgcca cttccacacg      360

gaggagcgcc tgtccacccc tcacccctac cccagccctc aggattgcgt ggaggctgct      420

gtctgccacg tcaaggacct cgagaatggc cagatgcggg aagtggagct gggctggggg      480

aaggtgttgc tggtgaagga caatggggag ttccacgccc tgggccataa gtgtccgcac      540

tacggcgcac ccctggtgaa aggcgttctg tcccgtggtc gggtgcgctg cccctggcac      600

ggcgcctgct tcaacatcag cactggggac ctggaggact tccctggcct ggacagtcta      660

cacaagttcc aggtgaagat tgagaaggag aaggtgtacg tccgggccag caagcaggcc      720

ctacagctgc agcgaaggac caaggtgatg gccaagtgta tctctccaag tgctgggtac      780

agcagtagca ccaatgtgct cattgtgggt gcaggtgcag ctggcctggt gtgtgcagag      840

acactgcggc aggagggctt ctccgaccgg atcgtcctgt gcacgctaga ccggcacctt      900

ccctacgacc gtcccaagct cagcaagtcc ctggacacac agcctgagca gctggccctg      960

aggcccaagg agtttttccg agcctatggc atcgaggtgc tcaccgaggc tcaggtggtc     1020

acagtggacg tgagaactaa gaaggtcgtg ttcaaggatg gcttcaagct ggagtacagc     1080

aagctgctgc tggcaccagg gagcagcccc aagactctga gctgcaaagg caaagaagtg     1140

gagaacgtgt tcactatccg gacgccagag gatgccaatc gcgtggtgag gctggcccga     1200

ggccgcaacg tggtcgtcgt gggagccggc ttcctgggga tggaggtggc cgcttacctg     1260

acggagaagg cccactctgt gtctgtggtg gagctggagg agacgccctt caggaggttc     1320

ctgggggagc gcgtgggtcg agccctcatg aagatgtttg agaacaaccg ggtgaagttc     1380

tacatgcaga cggaggtgtc tgagctgcgg ggccaggagg gaaagctgaa ggaggttgtg     1440

ctgaagagca gcaaggtcgt gcgggctgac gtctgcgtgg tgggcattgg tgcagtgccc     1500

gccacaggct tcctgaggca aagcggcatc ggtttggatt cccgaggctt catccctgtc     1560

aacaagatga tgcagaccaa tgtcccaggc gtgtttgcag ctggcgatgc tgtcaccttc     1620

ccccttgcct ggaggaacaa ccgcaaagtg aacattccac attggcagat ggctcatgct     1680

caggggcgcg tggcagccca gaacatgttg gcgcaggagg cggagatgag cactgtgccc     1740

tacctctgga ccgccatgtt tggcaagagc ctgcgctacg cgggctacgg agaaggcttc     1800

gacgacgtca tcatccaggg ggatctggag gagctgaagt ttgtggcttt ttacactaaa     1860

ggcgacgagg tgatcgccgt ggccagcatg aactacgatc ccattgtgtc caaggtcgct     1920

gaggtgctgg cctcaggccg tgccatccgg aagcgggagg tggagactgg cgacatgtcc     1980

tggcttacgg ggaaaggatc ctgagctcac atgcagtaga cttgggcagg caaagggggc     2040

accaagggca caggccaagc cttgggggca ggtgccaatc tccagtccca ggatccccca     2100

gggcagaacc tgagccctcc cagtgcttgc cttcagccac ctggctcccc tcctgggagg     2160

cctctgctgg atccagaaga tgctcaaccc tcaaggcctc tgctgccact gacagctggc     2220

actggaggca ggacaagccc tgcctcttct ccctctattg ggactggtcc cctgaagaac     2280

cctgcaacac gttaaacatt accgtaaaat taaaacgcac aaatttgcag atc            2333


<210> 2606
<211> 2040
<212> DNA
<213> Homo sapiens

<400> 2606
agtgccaaga tgtcgacggc ggcggttccg gagctgaagc agatcagccg ggtggaggcg       60

atgcgcctag ggccgggctg gagccactcg tgccacgcca tgctgtacgc cgccaaccct      120

gggcagctct tcggccgcat ccccatgcgc ttctcggtgc tgatgcagat gcgtttcgac      180

gggctgctgg gcttccccgg gggcttcgtg gaccggcgct tctggtcgct ggaggacggc      240

ctgaaccggg tgctgggcct gggcctgggc tgcctgcgcc tcaccgaggc cgactacctg      300

agctcgcacc tgaccgaggg cccacaccgc gtcgtggcgc acctgtacgc gcggcagctg      360

acgctggagc agctgcacgc cgtggagatc agcgcggtgc actcgcgcga ccacggcctg      420

gaggtggggc cgccgcccgg gccccgcccc ccgccccggg gtttggctct ggccccgtgg      480

aaggcaccga tgggtaacac gtctcctgag ggtcccctgg ccgggctggg tcgggtgtcg      540

ctgtctccag caatggggtg gggagagggg tctggggctg ggaggccggg aaaggagggg      600

cgggggtggg ggccggcgct ggggctccct cagggctgtg ttacatccgc cttgctgcct      660

gccattgcca atcctgggag tgggggagtg ggatcggtgg ggaggaaggg atgggggagg      720

agcggggatt gcttggggag ttgggaaact tgagcacagc gggggttgta aaacttggga      780

acctcatgtt gggcgtgaag gctcttggga tttgtacttt gtggtctgga agggctggac      840

tgcgggtgtt caggcttcgt tgggtggacg gggggagcat ggggtgcgga ccccggggtg      900

gggtggcctg ggtacgaggg gggggagtgc atggggtcag cctccacact tgcttgggga      960

ggagggggct gcactgctcc gagggagctg gctggcttct gccaggccct gcgtgggtct     1020

cccattaagt ccttggcaaa gctggctgct cataccctgg cctcatagct tccaggcccc     1080

tcctgctgga ggtgccattg tgtggcaggc ctggccccaa cccctacctc ctgtctgcgc     1140

aggtgctggg cctcgtgcgg gtcccgctgt acacccagaa ggaccgagtc ggaggcttcc     1200

ccaacttcct gagcaacgcc ttcgtgagca cggctaagtg ccagctcctc tttgccctca     1260

aggtgctcaa catgatgccc gaggagaagc tggttgaggc cctggctgca gccaccgaga     1320

agcagaagaa ggccctggag aagttgctcc cggcctcctc ttgagggctg cctgagctgg     1380

tggcaccctc ccctgggccg gaagactggg aattcctgct aagtgtggct tctagagtgt     1440

ttgtgtgtac cccgcttctg actgcctagg gcgagtgggc atcctgtcat catctccact     1500

gtcccaagca gtcactaggt ggcggccggg ccagctggaa cccagcccat cctctcaggc     1560

agagcagggt ggtccgggca cactgggcct gcctctccag cctcaggatg ctcttgttta     1620

ttctgggctc agaccctcct cttgtacgtc tcatcacagc tggtagagac ccaggagtgc     1680

ctgattgtcc cacaggggtg gcgcacagct ctgggaccac tcagaagatg ggatgtgtgg     1740

gtggaggatg ccttgtctcg gtcagctcat tcctgcctcc ttcctgagcc agttcagggc     1800

ctgggggaga gccagcttgg ggtaggaagt taataatact gttaatttgg gttgttgttg     1860

gatttacttt gctagatttt ctctttcacc acgtgtgaac tgtgggtgag gtttcaaagt     1920

agcttcaccc cacgtggctt ggttcccagg gacagtcagg gcctcggggg cccagctatg     1980

tacaacgaag ctgtcgaagg agaagacaat aaagtcgctc cgcagctgct ctgtgtgttt     2040


<210> 2607
<211> 2013
<212> DNA
<213> Homo sapiens

<400> 2607
ctttggcctg ccatctccca agggcaaacc tcacaactca ggcccaagtc acaggaatct       60

gaatggtggg gtgaccttct cctctagttt aatttcattg caatactgag aaacttcaac      120

tgttttgtct ttagaaggga aattcatgtt tgtgccaggc cagcctttgt aaaagccttt      180

gattggattc actagaagtc tgtcttcccg cagtacatat actgtgaatt ttctccttcg      240

gcatttcaac cacttggaat ggccactaaa gtggcttttg atctaaagta aactctgatt      300

ctgtgttgat ggggaaccat ttctctctaa catggtggtt tctttaagat gtttgacttg      360

ggccacatga gaataacaga tctttgggca gtccaagcaa gagcctcctg atctagcagc      420

caagactccc cctgaccttt ggccatgtac cccaaccctc tcatctactg cacctgctgg      480

gacccctgga acttgggacc acggaagcta atcaagaccc ctcaactacc acgcaagaac      540

tccacaggga gttccaagct aactcctctt gtaccagctc caaaaaatca caattacctc      600

caaccaacaa aacctgttgt ttccccaaaa atgaaaatcc attcagcaag gcaagaagag      660

actaataaat cattttatga agtgatcaac gtgtcacctg gctatcaact tgttcggaat      720

cgggaacaga tttctgtcac cttaggggat gagatgtttg ataggaaaaa gcggtgggaa      780

tcggagatcc cggacaaagg cagattttcc aggaccaaca tcatttctga cctagaagag      840

caaatctcag agctgacagc aataattgaa caaatgaaca gagaccacca gtctgcccag      900

aaattgctct ccagtgaaat ggatctccgc tgtgctgaga tgaaacagaa ctttgaaaac      960

aagaacaggg agctcaaaga ggcccatgaa gcagaactca gtgagttgga gaacaactac     1020

aaagcagcct tgaaggcaga gaagttggct gcccaagaga agctagagga gatgggaaaa     1080

gaatacaagt atttgaagaa tatgtttcgt acgtatcagg acagtattta tgatgaaatg     1140

gaagagaagt ggtcaaaaca gaaggcgaaa tggaagaagg atgagaagtt cgagcgagaa     1200

aatatcctgc tacagcaaaa aaaaaagatg accaaaaaat tcgaaatgga gtcaggagaa     1260

gaagataaga aaataaatga atcctgcagt gctgtctttg agaacttcat tcaagagaag     1320

gaggagctct tgaaacaaca tcaaagtgac accttgcaat tagaagagct gagaaaaacc     1380

aaagaggtgc cctggagaag agaccaaata aatagacatt ggcatgatgt cctgcaacag     1440

cttcttctta tgcaggtcat gcaggaagaa ttgcatgcac aagcccttat cctagagtca     1500

ctgaacacaa acctctacta tacccagttg gaactccaga aagagaaagc tatagtggga     1560

aatctggaga aaatgcttca aaccaagttt gctgaaactg aagaaaagta taagcacacc     1620

atacagatcc tgacggaaga gaacattcat ctgaagcaaa agataatttc taagaatgaa     1680

gaaatttgtg aaggatgttc tgggagattg gcctctatta ctgtttctaa ggatgattct     1740

gacactgtgc aagatggtag caagaaagga caagaatcat aaacaaaaag ttgctctgca     1800

ttgttgaaga tggttggcac accatttctg taggcccagg aaactcctgg gagggttttc     1860

ttgagaaaat gcatataatg agtttagttc ttgggttgct ctgactctct gaatgtctga     1920

aaatgtttga attcgcatct gaatttcaca gcttatcacg gactcttcac tgaaaaatga     1980

tgctctccat actgggagct gagctttctc tga                                  2013


<210> 2608
<211> 3346
<212> DNA
<213> Homo sapiens

<400> 2608
cgccgccgcg ggctcaagcg gggcggccgg gccagcgcgg ggcggcggcg ggcaggggcg       60

gcgagtgcgc gggcgctcgc cgccgccctt ctcggcgggc agcgcgcgag gaccaggccg      120

aggaggaagt ggcggcggcg gcggcgggac tgcgcgcccc agctccgatc cccgttccgc      180

gtccccgccg ccgggaggag gtgcccactc gctcgcggcg cgcgccggcc gccagactcg      240

gcctgtgggc gatttcctcc ggacccaggc tccccgcccg aggaggaaga tgcagacctt      300

tctgaaaggg aagagagttg gctactggct gagcgagaag aaaatcaaga agctgaattt      360

ccaggccttc gccgagctgt gcagctgaac cttagccggc cgatcgagga gcagggcccc      420

ctggacgtca tcatccacaa gctgactgac gtcatccttg aagccgacca gaatgatagc      480

cagtccctgg agctggtgca caggttccag gagtacatcg atgcccaccc tgagaccatc      540

gtcctggacc cgctccctgc catcagaacc ctgcttgacc gctccaagtc ctatgagctc      600

atccggaaga ttgaggccta catggaagac gacaggatct gctcgccacc cttcatggag      660

ctcacgagcc tgtgcgggga tgacaccatg cggctgctgg agaagaacgg cttgactttc      720

ccattcattt gcaaaaccag agtggctcat ggcaccaact ctcacgagat ggctatcgtg      780

ttcaaccagg agggcctgaa cgccatccag ccaccctgcg tggtccagaa tttcatcaac      840

cacaacgccg tcctgtacaa ggtgttcgtg gttggcgagt cctacaccgt ggtccagagg      900

ccctcactca agaacttctc cgcaggcaca tcagaccgtg agtccatctt cttcaacagc      960

cacaacgtgt caaagccgga gtcgtcatcg gtcctgacgg agctggacaa gatcgagggc     1020

gtgttcgagc ggccgagcga cgaggtcatc cgggagctct cccgggccct gcggcaggca     1080

ctgggcgtgt cactcttcgg catcgacatc atcatcaaca accagacagg gcagcacgcc     1140

gtcattgaca tcaatgcctt cccaggctac gagggcgtga gcgagttctt cacagacctc     1200

ctgaaccaca tcgccactgt cctgcagggc cagagcacag ccatggcagc cacaggggac     1260

gtggccctgc tgaggcacag caagcttctg gccgagccgg cgggcggcct ggtgggcgag     1320

cggacatgca gcgccagccc cggctgctgc ggcagcatga tgggccagga cgcgccctgg     1380

aaggctgagg ccgacgcggg cggcaccgcc aagctgccgc accagagact cggctgcaac     1440

gccggcgtgt cgcccagctt ccagcagcat tgtgtggcct ccctggccac caaggcctcc     1500

tcccagtagc cacggagccg ggacccagag gggcagcgca gggcgcagag cacacccgct     1560

gggccagcag ctcccaacgg cgatgctact actaagaatc cccagtgatc tgattcttct     1620

gttttttaat ttttaacctg attctctgat gtcatgatct aaatgagggg tagtggggga     1680

tggaagagag taccaggtgg tccaccgttg gggagtgggg ccgtccgcct gctctctact     1740

gtgcagacct cctaactgag tttacacacg cttgtgtttg caacactagg tctggatggg     1800

aggtgagggg tgtgcgtatg gctgccatgc cagtgtctgt gcacatccct gtctgttggt     1860

ctccatggcc actgtggacc gggacccttg ggggaagcct gcccatgtcg ggctgtggga     1920

ggctgatcgg tgcatgtgag agtggcttcc cttctgcctg actccccact ccctgacctg     1980

ccccttcctt gtttttcctc ctactggtct ccaccaaggc tttgttagcc cccaccctgc     2040

ctggtgtgca gctaacccct ccctccccac agccagagga ggccacagac ccctcagggg     2100

agttccgcgc tggggtctgg gctgtgctcc ctcactaaag ggaaggaaag gaagctgggc     2160

gtcctctggg ccccccaaca cacgtcccat ttagccctgc acagcggtct ccttccccta     2220

agccagcact gctgctccct ggagcccggg aaggaggctg cctggctgga ggcccgagcc     2280

gatggcgcct gtgctgagga tttgtgctgt gatttgggca aatcattcca ggtctttggg     2340

cctccacccc cttgtctcta gtggacattt gagatcagag agcaccacag ggctggcttt     2400

gtgccctaac ccctgggatg cagcctgcct ttccataaag tcacctaggt gaggataggc     2460

gcgggagcct cggcatgaca ccatggagat cggggccctc ttcccagtgg gttcactcct     2520

tttcacacct gctgggtccc tcctcaccca gcaggcctgg tccacctctc attgcaagcc     2580

ccaagcactg agccagcagg tgccagggag ccacccgccc cccatcgctt ctgcacacct     2640

cagactcacc ccatcacctt ggcagcaaag cactggctct gccgtctgac ccctgatcca     2700

ggcagccccc tctgcagaga aaagggttgg ggagaagcct ctgcagtcct ggaagatgtg     2760

gggtgctggg tgagaggcat cagcccccac aagtatgttt ttgtgtctta agatagcagt     2820

ttactttgaa aaagtgaaaa aggcttccgg gctgtcctct gcccagtgag atggaggacg     2880

ctagagaaag tgctgagtgt cccgagagag gcccccgagc cagtgcatgg aggtccttcg     2940

gcctggctca gctgggctgc aggatgccca ctttgaggag ggaggcacag ggcttgggcg     3000

aggggcagag gccatcagaa ctgcccggct tttttggaaa ctgaggaccc aacaactaac     3060

cacgtttaca cgacttgagt tttgaacccc gattaatgtc tgtacgtcac ctttcctagt     3120

tctgaccctg agccctgggg aacaggaaag cgtggctggc ctcttgcact gctttgtctc     3180

caaaataaac tactgaaatc aaaccgcatt tcacacgtgt ttacacatgt tgctcaagtt     3240

tgttatgtca tactcccagt ccttaaaaga cgtttaataa aacagcttta ccttttaaaa     3300

ataaaatttc aatcccagtc tgcctcaggt acgggtgggg gtgtgc                    3346


<210> 2609
<211> 1484
<212> DNA
<213> Homo sapiens

<400> 2609
actctggccc ggttctcggt ggtgcgggag cgggcgggag cagcggccgc tctggtcggc       60

ggacgtgctg ccgagtagtc ccggaagcga agcagcgatg gcggagagtc cgactgagga      120

ggcggcaacg gcgggcgccg gggcggcggg ccccggggcg agcagcgttg ctggtgttgt      180

tggcgttagc ggcagcggcg gcgggttcgg gccgcctttc ctgccggatg tgtgggcggc      240

ggcggcggca gcgggccgcg ctgcttagcc actgggaccc cacgctcagc tccgactggg      300

acggcgagcg caccgcgccg cagtgtctac tccggatcaa gcgggatatc atgtccattt      360

ataaggagcc tcctccagga atgttcgttg tacctgatac tgttgacatg actaagattc      420

atgcattgat cacaggccca tttgacactc cttatgaagg gggtttcttc ctgttcgtgt      480

ttcggtgtcc gcccgactat cccatccacc cacctcgggt caaactgatg acaacgggca      540

ataacacagt gaggtttaac cccaacttct accgcaatgg gaaagtctgc ttgagtattc      600

taggtacatg gactggacct gcctggagcc cagcccagag catctcctca gtgctcatct      660

ctatccagtc cctgatgact gagaacccct atcacaatga gcccggcttt gaacaggaga      720

gacatccagg agacagcaaa aactataatg aatgtatccg gcacgagacc atcagagttg      780

cagtctgtga catgatggaa ggaaagtgtc cctgtcctga acccctacga ggggtgatgg      840

agaagtcctt tctggagtat tacgacttct acgaggtggc ctgcaaagat cgcctgcacc      900

ttcaaggcca aactatgcag gacccttttg gagagaagcg gggccacttt gactaccagt      960

ccctcttgat gcgcctggga ctgatacgtc agaaagtgct ggagaggctc cataatgaga     1020

atgcagaaat ggactctgat agcagttcat ctgggacaga gacagacctt catgggagcc     1080

tgagggttta gaccctgctc ccatctcccc ttcccccact caagagtccc agcagaatcc     1140

cttcccccca ccccagggat ggagaggcac tgtgtatctc cctccagact cgaagtcatc     1200

ctgcaagatg gcaagaacca agcaagctcc gatcccaggg tgtgggagtg ggggcctgtt     1260

cccggtctga cctccttggc actggagcat ctggggcttc gttcatccat tcatcccgta     1320

tcaggggcca aggtaccttt acaggagcac ctagagcgag ggcctttggc aaaaacaaaa     1380

caaccaacac acctctccac agggccagct ccttagggat aagtggaaga tggaaattgc     1440

aattccaaga gggagtgtgc ccaaatgatt tatggggata cctg                      1484


<210> 2610
<211> 975
<212> DNA
<213> Homo sapiens

<400> 2610
ccgccttgca gtttgatctc agactgctgt gctggcaatc agcgagactc cgtgggcgta       60

ggaccctccg agccaggctg ctatccatgt ccagggccaa acatgaatcc tattgctctt      120

gggagccgct ggcttgctta tgcagaaaac aagttgattc gatgtcatca gtcccgtggt      180

ggagcctgtg gagacaacat tcagtcttat actgccacag tcattagtgc tgctaaaaca      240

ttgaaaagtg gcctgacaat ggtagggaaa gtggtgactc agctgacagg cacactgcct      300

tcaggtgtga cagaagatga tgttgccatc cacagtaatt cacggcggag tcctttggtc      360

ccaggcatca tcacagttat tgacaccgaa accgttggag agggccaggt gcttgtgagt      420

gaggattctg acagtgatgg cattgtggcc cacttccctg cccatgagaa gccagtgtgc      480

tgcatggctt ttaatacaag tggaatgctt ctagtcacaa cagacaccct tggccatgac      540

tttcatgtct tccaaattct gactcatcct tggtcctcat cacaatgtgc tgtccaccat      600

ctgtatactc ttcacagggg agaaactgaa gccaaagtac aggacatctg cttcagccat      660

gactgtcgct gggttgtggt cagtactctc cggggtactt cccacgtttt ccccatcaac      720

ccttatggtg gccagccttg tgttcgtaca catatgtcac cacgagtagt gaatcgcatg      780

agccgtttcc agaaaagtgc tggactggaa gagattgaac aagaactgac gtctaagcaa      840

ggaggtcgct gtagccctgt tccaggtcta tcaagcagcc cttctgggtc acccttgcat      900

gggaaactga acagccaaga ctcctataac aattttacca acaacaaccc tggcaaccct      960

cggctctctc ctctt                                                       975


<210> 2611
<211> 4421
<212> DNA
<213> Homo sapiens

<400> 2611
gctgccaccc attggctcag gccgatacca cgcgccccga tacccggcac aggagccacc       60

tcccagagcc ccgcagtcca tgcctcagtc ggcctgcgct cctcagcctg gcggttctac      120

ctccgagggt tcgcccgccc ttggttttcc ttacacctta gcctttggct cctttgacca      180

ctcgaagccc cacagcgtgt tccagcggac ttcaccagca gacccagaag tggtgggtga      240

aacactgcct ctgttcctcc ttgagcctgt cgggagctgc tgcctgccac caccatgtct      300

gctgcaaatc ctgagactcc aaactcaacc atctccagag aggccagcac ccagtcttca      360

tcagctgcag ctagccaagg ctgggtgtta ccagaaggca aaatcgtgcc aaacactgtt      420

tttgttggtg gaattgatgc taggatggat gaaactgaga ttggaagctg ctttggtaga      480

tacggttcag tgaaagaagt gaagataatc acgaatcgaa ctggtgtgtc caaaggctat      540

ggatttgttt cgtttgttaa tgacgtggat gtccagaaga tagtaggatc acagatacat      600

ttccatggta aaaagctgaa gctgggccct gcaatcagga aacaaaagtt atgtgctcgt      660

catgtgcagc cacgtccttt ggtagttaat cctcctcctc caccacagtt tcagaacgtc      720

tggcggaatc caaacactga aacctacctg cagccccaaa tcacgccgaa tcctgtaact      780

cagcacgttc agtctgctgc aaatcctgag actccaaact caaccatctc cagagaggcc      840

agcacccagt cttcatcagc tgcagctagc caaggctggg tgttaccaga aggcaaaatc      900

gtgccaaaca ctgtttttgt tggtggaatt gatgctagga tggatgaaac tgagattgga      960

agctgctttg gtagatacgg ttcagtgaaa gaagtgaaga taatcacgaa tcgaactggt     1020

gtgtccaaag gctatggatt tgtttcgttt gttaatgacg tggatgtcca gaagatagta     1080

ggatcacaga tacatttcca tggtaaaaag ctgaagctgg gccctgcaat caggaaacaa     1140

aagttatgtg ctcgtcatgt gcagccacgt cctttggtag ttaatcctcc tcctccacca     1200

cagtttcaga acgtctggcg gaatccaaac actgaaacct acctgcagcc ccaaatcacg     1260

ccgaatcctg taactcagca cgttcagtct gctgcaaatc ctgagactcc aaactcaacc     1320

atctccagag aggccagcac ccagtcttca tcagctgcag ctagccaagg ctgggtgtta     1380

ccagaaggca aaatcgtgcc aaacactgtt tttgttggtg gaattgatgc taggatggat     1440

gaaactgaga ttggaagctg ctttggtaga tacggttcag tgaaagaagt gaagataatc     1500

acgaatcgaa ctggtgtgtc caaaggctat ggatttgttt cgtttgttaa tgacgtggat     1560

gtccagaaga tagtaggatc acagatacat ttccatggta aaaagctgaa gctgggccct     1620

gcaatcagga aacaaaagtt atgtgctcgt catgtgcagc cacgtccttt ggtagttaat     1680

cctcctcctc caccacagtt tcagaacgtc tggcggaatc caaacactga aacctacctg     1740

cagccccaaa tcacgccgaa tcctgtaact cagcacgttc aggcttactc tgcttatcca     1800

cattcaccag gtcaggtcat cactggatgt cagttgcttg tatataatta tcaggaatat     1860

cctacttatc ccgattcagc atttcaggtc accactggat atcagttgcc tgtatataat     1920

tatcagccat ttcctgctta tccaagatca ccatttcagg tcactgctgg atatcagttg     1980

cctgtatata attatcaggc atttcctgct tatccaaatt caccatttca agtcgccact     2040

ggatatcagt tccctgtata caattatcag ccatttcctg cttatccaag ttcaccattt     2100

caggtcactg ctggatatca gttgcctgta tataattatc aggcatttcc tgcttatcca     2160

aattcaccat ttcaagtcgc cactggatat cagttccctg tatacaatta tcaggcattt     2220

cctgcttatc caaattcacc agttcaggtc accactggat atcagttgcc tgtatacaat     2280

tatcaggcat ttcctgctta tccaagttca ccatttcagg tcaccactgg atatcagttg     2340

cctgtatata attatcaggc atttcctgct tatccaaatt cagcagttca ggtcaccact     2400

ggatatcagt tccatgtata caattaccag atgccaccgc agtgccctgt tggggagcaa     2460

aggagaaatc tgtggaccga agcatacaaa tggtggtatc ttgtctgttt aatccagaga     2520

agagactgat aaattccgtt gttactcaag atgactgctt caagggtaaa agagtgcatc     2580

gctttagaag aagtttggca gtatttaaat ctgttggatc ctctcagcta tctagtttca     2640

tgggaagttg ctggttttga atattaagct aaaagttttc cactattaca gaaattctga     2700

attttggtaa atcacactga aactttctgt ataacttgta ttattagact ctctagtttt     2760

atcttaacac tgaaactgtt cttcattaga tgtttattta gaacctggtt ctgtgtttaa     2820

tatatagttt aaagtaacaa ataatcgaga ctgaaagaat gttaagattt atctgcaagg     2880

atttttaaaa aattgaaact tgcattttaa gtgtttaaaa gcaaatactg actttcaaaa     2940

aagtttttaa aacctgattt gaaagctaac aattttgata gtctgaacac aagcatttca     3000

cttctccaag aagtacctgt gaacagtaca atatttcagt attgagcttt gcatttatga     3060

tttatctaga aatttacctc aaaagcagaa tttttaaaac tgcattttta atcagtggaa     3120

ctcaatgtat agttagcttt attgaagtct tatccaaacc cagtaaaaca gattctaagc     3180

aaacagtcca atcagtgagt cataatgttt attcaaagta ttttatcttt tatctagaat     3240

ccacatatgt atgtccaatt tgattgggat agtagttagg ataactaaaa ttctgggcct     3300

aattttttaa agaatccaag acaaactaaa ctttactggg tatataacct tctcaatgag     3360

ttaccattct tttttataaa aaaaattgtt ccttgaaatg ctaaacttaa tggctgtatg     3420

tgaaatttgc aaaatactgg tattaaagaa cgctgcagct tttttatgtc actcaaaggt     3480

taatcggagt atctgaaagg aattgttttt ataaaaacat tgaagtatta gttacttgct     3540

ataaatagat ttttattttt gttttttagc ctgttatatt tccttctgta aaataaaata     3600

tgtccagaag aggcatgttg tttctagatt aggtagtgtc ctcattttat attgtgacca     3660

cacagctaga gcaccagagc ccttttgcta tactcacagt cttgttttcc cagcctcttt     3720

tactagtctt tcaggaggtt tgctcttaga actggtgatg taaagaatgg aagtagctgt     3780

atgagcagtt caaaggccaa gccgtggaat ggtagcaatg ggatataata cctttctaag     3840

ggaaacattt gtatcagtat catttgatct gccatggaca tgtgtttaaa gtggctttct     3900

ggcccttctt tcaatggctt cttccctaaa acgtggagac tctaagttaa tgtcgttact     3960

atgggccata ttactaatgc ccactggggt ctatgatttc tcaaaatttt cattcggaat     4020

ccgaaggata cagtctttaa actttagaat tcccaagaag gctttattac acctcagaaa     4080

ttgaaagcac catgactttg tccattaaaa aattatccat agttttttta gtgcttttaa     4140

cattccgaca tacatcattc tgtgattaaa tctccagatt tctgtaaatg atacctacat     4200

tctaaagagt taattctaat tattccgata tgaccttaag gaaaagtaaa ggaataaatt     4260

tttgtctttg ttgaagtatt taatagagta aggtaaagaa gatattaagt ccctttcaaa     4320

atggaaaatt aattctaaac tgagaaaaat gttcctacta cctattgctg atactgtctt     4380

tgcataaatg aataaaaata aacttttttt cttcaaatgt g                         4421


<210> 2612
<211> 1938
<212> DNA
<213> Homo sapiens

<400> 2612
gggttccggt gttcgcggag gagtcgaggc acggagaggc ttcgggggag ggacggaaag       60

aagggtggcc cgccaggcgg gcggggtcca tggattcggg gtgagggccg tccgcggcct      120

cgctttcgcc tcctccgagc cgggccggcg atggccgcag ctgtgaggcg aggtcgggtc      180

ccgtagcggc gcgcagcctc cttgggggac tcggggtcct gtatattttg aatacatctg      240

tcttcataaa atacaccatg tccaaaatct aaaagggcca attccaaatt attccaccag      300

ctttgaaggg aattgaagca agaataacaa gacagaagaa tagaaggaag gtgataggat      360

gtgatgatag aatttgtgat agccaagcaa caacttttcc taattcggca tgttaaaaaa      420

taagggtcac tcatctaaga aagataactt ggcagtcaat gcagttgctt tacaagatca      480

cattttacat gatcttcaac ttcgaaatct ttcagttgca gatcattcta agacacaagt      540

acaaaagaaa gagaacaaat ctctaaaaag agatacaaag gcaataatag atactggact      600

taaaaaaact acacagtgcc ccaaactaga agactcagaa aaagaatatg ttcttgatcc      660

caaaccgccg ccgttgactt tggcacagaa gttgggcctc attgggcctc caccacctcc      720

actgtcatca gatgaatggg agaaggtgaa acagcgctct ctcctgcaag gggactccgt      780

gcaaccatgc cccatctgta aagaagaatt cgagcttcgt cctcaggtgc tgctttcatg      840

ctcccatgtg ttccacaaag catgtcttca ggcttttgaa aagttcacaa ataagaaaac      900

ctgtcctctc tgtagaaaga accagtatca aacccgagtg atacacgatg gggcccgcct      960

gttcagaatc aagtgtgtga ccagaatcca agcctactgg agaggatgtg ttgttagaaa     1020

gtggtacaga aacctgagga aaacagtacc tcccacagat gccaagttaa gaaaaaaatt     1080

ctttgaaaaa aagttcacag aaatcagcca ccgcatcctg tgctcataca acaccaacat     1140

tgaagagctc tttgcagaaa tcgatcagtg cttggccata aatcgaagtg ttcttcagca     1200

gttggaagaa aaatgtggcc atgagatcac agaagaggaa tgggagaaaa tccaagtgca     1260

ggctctgcgc cgggagaccc acgagtgctc catctgcctg gcccctctct ccgctgctgg     1320

cggtcagcgc gtgggtgcag gcaggcgttc cagagagatg gccctcctgt cctgctcaca     1380

tgtgttccac catgcgtgtc tgctggcact agaggagttc tccgtgggag acaggcctcc     1440

tttccatgcc tgtcctctct gccgctcctg ctaccagaag aagattcttg aatgttgaat     1500

tcatagtcaa ggaaagttag gtaattctga ggaaaaaagt ttaccatcat tttggatgaa     1560

ctgcatgagt tctgggttaa gtactacaat gtaatctgtt tcccagggaa ataagctatt     1620

ggtagttgta ggaaatctta gtatatttta aaagctgaca tcccacctaa ttttaatctt     1680

tggtctctaa aaagtaaatt tcaaatttat gagtttaatc acttcaaata tgaatagcaa     1740

aaaatgagag cttgcttact tctaaaaatt gaggttaaga tatagctagt gtctgaacga     1800

cactccttaa agtaagttcc aaatgtaaaa cactccttaa gttccaaatg ttttccgcta     1860

atagtctgtc ctaaagcctt tgccattcct aatactcgtt ttgtaataat tgctgtattt     1920

ctgtgtaata aaatataa                                                   1938


<210> 2613
<211> 3966
<212> DNA
<213> Homo sapiens

<400> 2613
gcggccggtg ggctccgccc ttaaccaaga tggcgatacg cgtgggaccg gaaagagttt       60

atagatttcc cgtctaccct acctctgagg tgaaggtggg actgccctgt ggagcccacc      120

ctttccgtta tgcgcccgcg cggcgcaatg acgtaacaca ggcccgccca ctgcccctgt      180

tgggttcctg agtcgtgctg cgtcgacaac ggtagtgacg cgtattgcct ggaggatggc      240

ggacgccggc attcgccgcg tggttcccag cgacctgtat cccctcgtgc tcggcttcct      300

gcgcgataac caactctcag aggtggccaa taagttcgcc aaagcgacag gagctacaca      360

gcaggatgcc aatgcctctt ccctcttaga catctatagc ttctggctca agtctgccaa      420

ggtcccagag cgaaagttac aggcaaatgg accagtggct aagaaagcta agaagaaggc      480

ctcatccagt gacagtgagg acagcagcga ggaggaggag gaagttcaag ggcctccagc      540

aaagaaggct gctgtacctg ccaagcgagt cggtctgcct cctgggaagg ctgcagccaa      600

agcatcagag agtagcagca gtgaagagtc cagtgatgat gatgatgagg aggaccaaaa      660

gaaacagcct gtccagaagg gagttaagcc ccaagccaag gcagccaaag ctcctcctaa      720

gaaggccaag agctctgatt ctgattctga ctcaagctcc gaggatgagc caccaaagaa      780

ccagaagcca aagataacac ctgtgacagt taaagctcag actaaagccc ctcccaaacc      840

agctcgagca gcacctaaaa tagccaatgg taaagcagcc agtagcagca gtagcagcag      900

cagcagcagt agcagtgatg actcagagga ggagaaggca gcagccaccc ccaagaaggt      960

ctggaccata acttctgtca gggcagagac tgtacctaaa aagcaagttg tggccaaggc     1020

cccagtgaaa gcagctacca cccctacccg gaagagttct agcagtgagg attcctccag     1080

tgacgaggaa gaggagcaaa aaaaacccat gaaaaataaa ccaggtccct acagttcagt     1140

ccccccgcct tctgctcccc caccaaagaa gtctctggga acccagcctc ccaagaaggc     1200

tgtggagaag cagcagcctg tggaaagcag tgaagacagc agtgatgagt ctgattcaag     1260

ttctgaagaa gagaagaaac ccccaactaa ggcagtagtc tctaaagcaa ccactaaacc     1320

acctccagca aagaaagcag cagagagctc ttcagacagc tcagactctg acagctctga     1380

ggatgatgaa gctccttcta agccagctgg taccaccaag aattcttcaa ataagccagc     1440

tgtcaccacc aagtcacctg cagtgaagcc agctgcagcc cccaagcaac ctgtgggcgg     1500

tggccagaag cttctgacga gaaaggctga cagcagctcc agtgaggaag agagcagctc     1560

cagtgaggag gagaagacaa agaagatggt ggccaccact aagcccaagg cgactgccaa     1620

agcagctcta tctctgcctg ccaagcaggc tcctcagggt agtagggaca gcagctctga     1680

ttcagacagc tccagcagtg aggaggagga agagaagaca tctaagtctg cagttaagaa     1740

gaagccacag aaggtagcag gaggtgcagc cccttccaag ccagcctctg caaagaaagg     1800

aaaggctgag agcagcaaca gttcttcttc tgatgactcc agtgaggaag aggaagagaa     1860

gctcaagggc aagggctctc caagaccaca agcccccaag gccaatggca cctctgcact     1920

gactgcccag aatggaaaag cagctaagaa cagtgaggag gaggaagaag aaaagaaaaa     1980

ggcggcagtg gtagtttcca aatcaggttc attaaagaag cggaagcaga atgaggctgc     2040

caaggaggca gagactcctc aggccaagaa gataaagctt cagaccccta acacatttcc     2100

aaaaaggaag aaaggagaaa aaagggcatc atccccattc cgaagggtca gggaggagga     2160

aattgaggtg gattcacgag ttgcggacaa ctcctttgat gccaagcgag gtgcagccgg     2220

agactgggga gagcgagcca atcaggtttt gaagttcacc aaaggcaagt cctttcggca     2280

tgagaaaacc aagaagaagc ggggcagcta ccggggaggc tcaatctctg tccaggtcaa     2340

ttctattaag tttgacagcg agtgacctga ggccatcttc ggtgaagcaa gggtgatgat     2400

cggagactac ttactttctc cagtggacct gggaaccctc aggtctctag gtgagggtct     2460

tgatgaggac agaagtttag agtaggtcct aagactttac agtgtaacat cctctctggt     2520

ccttttctgt gttcctagtt ttgtacagac ttgtttttga gtgttgagta gcagggacaa     2580

aataagggaa tgttattttt taagaaaatt cattttcatt gttgtctcct tccttttctg     2640

tgaaagtcct catactgaga aatttgtata ttttatatta aatcacttac tattgatttt     2700

tgttgtgatt ttcaaaggtg gattcccaca gataaaatct tggctattgc ccaaaacata     2760

gtaaagggtc acgtgtgact ttttataata ggaagaaaat tctgcctttg tgagtgcaca     2820

tgtccacatt tcatccctcc ttccctcaaa accctagaga ggggcattaa agaattgttg     2880

atgtatatgc aatgtctgtt aagcatgcac tatgtatttc atcctcattt attgggtctg     2940

ggactgaagt ttttagccag catggaccta acctactttt tgggataaaa ttctctgttt     3000

tgttacaggc aaaattctgg tatggcgtga atgccatggg tcattctgaa tatatttttt     3060

tctgtaattt tatcattaca cgatgtttgc aatacgtgct ttgtttttta atttgaaagc     3120

aaacttttct actgttgaaa gacatttttt gacaacttga cccttcctag tattgagttc     3180

taagttgagg actgcatctt ctcgtttttt acagtataga gaacaaaatg acatgagttt     3240

gaaaaataca tatcacttgg tattgctgtc ttggttgcag tggtgataca gaattggttt     3300

cattaattcc tacatggttg agaatcactg atcaagaaag tggggggaaa aaaaacaaac     3360

gttaaaacct caatcctcag taggaaggta gattacatta ggtgaaatta taggtaatct     3420

atgtatgtgc taatggggtt ggaaagaacc ttacagagca tattacctga taaactggag     3480

tgggtttggg agaacaaact aataggatta ttgtgtctcc tagttggtac ctgggagcaa     3540

ttgacatgcc cccttcagaa ccttaactgt tagtagcagt ggctgtaaca acacaaacca     3600

gtgaccagag ataacagctt ttaggccaag ctggcctgac ggtatggctg caggaagtga     3660

ctgagcagta gcggtactca gccagaccaa gacggagagg gaagagtcca cagctttctg     3720

gaagctaagg cattctggtg gtagaaaagt gtgccccaag ccttcatgga cgagttatag     3780

gtcttaagat tagtctcctc ttgtttggat tccatacttg ctaaataacc tgataataac     3840

ctggttttcc atgtaactgc ctctaggaag aaaatgtact gttcatgctg acacagatat     3900

ttcagtctgc atggtaaaag ttctaaatct tactacaaaa taataaactg gctggtttat     3960

aatgtg                                                                3966


<210> 2614
<211> 1059
<212> DNA
<213> Homo sapiens

<400> 2614
atattcctta tgccccccgg ctggagctgc agcgccagcc tcccgcccta ccgccgtttc       60

cgtgggctga gccgccctgc ggccacccgg tcccgcgcca gtcagtgcgc cgccttcccg      120

ggggacacct cactcgcccc ttgctgcgcc gtcggctccc cagcgcttcc actcgacctc      180

gcaccccact cgcctgctgg gctcgagcgg gggtgtgcgg cgattatccg tgcaggcggt      240

gcggggagtg ggtctgggag agcggccctt tgcgcgtgtt cctcaggccc tttctgccct      300

ggtttcccag ccagtggaca ggaagcttca ttcaagcaaa gctgggtgca aacatgagtg      360

tcgttcttgg tagagggcgg ttggaagcta cagaaagatc tagaagaggt aaaggtgttg      420

ctggaaaagg ctactaggaa aagagtacgt gatgccctta cagctgaaaa atccaagatt      480

gagacagaaa tcaagaacaa gatgcaacag aaatcacaga agaaagcaga acttcttgat      540

aatgaaaaac cagctgctgt ggttgctccc attacaacgg gctatacggt gaaaatcagt      600

aattatggat gggatcagtc agataagttt gtgaaaatct acattacctt aactggagtt      660

catcaagttc ccactgagaa tgtgcaggtg catttcacag agaggtcatt tgatcttttg      720

gtaaagaatc taaatgggaa gagttactcc atgattgtga acaatctctt gaaacccatc      780

tctgtggaag gcagttcaaa aaaagtcaag actgatacag ttcttatatt gtgtagaaag      840

aaagtggaaa acacaaggtg ggattacctg acccaggttg aaaaggagtg caaagaaaaa      900

gagaagccct cctatgacac tgaaacagat cctagtgagg gattgatgaa tgttctaaag      960

aaaatttatg aagatggaga cgatgatatg aagcgaacca ttaataaagc ctgggtggaa     1020

tcaagagaga agcaagccaa aggagacacg gaattttga                            1059


<210> 2615
<211> 3531
<212> DNA
<213> Homo sapiens

<400> 2615
agatgctgag gaatatggca agaagttggg gttcaaagtc tgatgccaaa gctagcaacc       60

cgagaaataa aaccgctgat caccagctcc ccactcaggc ccagccccct tttagagccc      120

ccagactccc cacgcagggc cctagccccc tagtcttccc cgtcaatgcc ctgttggcaa      180

tacagccatc aggttctatc agagtgagct gtttttatat gattattttc ccccctggga      240

agacggcttt gtctgtgaaa gtccccccaa ccaggcgcct tataaacgcc taaaacagac      300

agagttgagg agaaaggagg ggaaaggagg agggagcaaa cccggagggg ggccctgagg      360

ttcgcagcgg gcaggatggg ggtatgaggc cggagtcggc ggctcccagg cccccagccc      420

cgtcagggcg cccccgtccc caggcgccag agccggggtc cgcagccccc tagcactccc      480

tggacggccg cgggcctccc acaggcctcg aagtccagag actgatcctg cgaccggaaa      540

cgcccccctg cccagggggc cctgccagcg acgcccctgc cagcccccga gaccccctgc      600

gcggggtcgg caaagcatct ggacacccca gaagctccgg acgccgaaga gagaggcccc      660

acgaaaattt caagacacct cctgggggct gcaggggcgg ccaagtctcc ccagcgccag      720

gtgcccccgg ccacacgtct gcagatctcc aggggagccc accagcctag tcaacatggc      780

ctcggaagac attgccaagc tggcagagac acttgccaag actcaggtgg ccgggggaca      840

gctgagtttc aaaggcaaga gcctcaaact caacactgca gaagatgcta aagatgtgat      900

taaagagatt gaagactttg acagcttgga ggctctgcgt ctggaaggca acacagtggg      960

cgtggaagca gccagggtca tcgccaaggc cttagagaag aagtcggagt tgaagcgctg     1020

ccactggagt gacatgttca cgggaaggct gcggaccgag atcccaccag ccctgatctc     1080

actaggggaa ggactcatca cagctggggc tcagctggtg gagctggact taagcgacaa     1140

cgcattcggg cccgacggtg tgcaaggctt cgaggccctg ctcaagagct cagcctgctt     1200

caccctgcag gaactcaagc tcaacaactg tggcatgggc attggcggcg gcaagatcct     1260

ggctgcagct ctgaccgaat gtcaccggaa atccagtgcc caaggcaagc ctctggccct     1320

gaaggtcttt gtggctggca gaaaccgtct ggagaatgat ggcgccactg ccttggcaga     1380

agcttttagg gtcatcggga ccctggagga ggtccacatg ccacagaatg ggatcaacca     1440

ccctggcatc actgccctgg cccaggcttt cgctgtcaac cccctgctgc gggtcatcaa     1500

cctgaatgac aacaccttca ctgagaaggg cgccgtggcc atggccgaga ccttgaagac     1560

cttgcggcag gtggaggtga ttaattttgg ggactgcctg gtgcgctcca agggtgcagt     1620

tgccattgca gatgccatcc gcggcggcct gcccaagcta aaggagctga acttgtcatt     1680

ctgtgaaatc aagagggatg ctgccctggc tgttgctgag gccatggcag acaaagctga     1740

gctggagaag ctggacctga atggcaacac cctgggagaa gaaggctgtg aacagcttca     1800

ggaggtgctg gagggcttca acatggccaa ggtgctggcg tccctcagtg atgacgagga     1860

cgaggaggag gaggaggaag gagaagagga agaagaggaa gcagaagaag aggaggagga     1920

agatgaggaa gaggaggaag aagaggagga ggaggaggaa gaagagcctc agcagcgagg     1980

gcagggagag aagtcagcca cgccctcacg gaagattctg gaccctaaca ctggggagcc     2040

agctcccgtg ctgtcctccc cacctcctgc agacgtctcc accttcctgg cttttccctc     2100

tccagagaag ctgctgcgcc tagggcccaa gagctccgtg ctgatagccc agcagactga     2160

cacgtctgac cccgagaagg tggtctctgc cttcctaaag gtgtcatctg tgttcaagga     2220

cgaagctact gtgaggatgg cagtgcagga tgcagtagat gccctgatgc agaaggcttt     2280

caactcctcg tccttcaact ccaacacctt cctcaccagg ctgctcgtgc acatgggtct     2340

gctcaagagt gaagacaagg tcaaggccat tgccaacctg tacggccccc tgatggcgct     2400

gaaccacatg gtgcagcagg actatttccc caaggccctt gcacccctgc tgctggcgtt     2460

cgtgaccaag cccaacagcg ccctggaatc ctgctccttc gcccgccaca gtctgctgca     2520

gacgctgtac aaggtctaga ctcaaagcct ctcccatccc ttggcctgga ccagtgagct     2580

ggggagggac tcggatgaac tgaggcgcag cctacgccat tgccttggac aggactctgg     2640

ccacaggcag ggcgggtctg tgtcccatgt gtcctgtcag tcccctgagt atgtgtgtgg     2700

gtgtggcgca tgtgcaggtc tgtgcctcct gtcgggattt gggttttaac gtcttctgct     2760

ggcccagccc tgctctgttg tggggagttg gcccccaggg gaaagggctg tgagctgctc     2820

cgccattaaa ctcacctcca cctgagggcg ctctgctgat ctccgcctgg gccctgatgg     2880

ccgtccccac ccacctgcct tccggcccgg ctccctggcg gagccagaac ccagggagtt     2940

gcccgcgtgc tgtccttccc ctctgtgttg tgattgggtt gtttcctgcc ctgcctgggg     3000

ctgcttctcg tcaccaagcc ctggtcctgc ggcagctgtc acccctacca tccataccac     3060

tgtgctgacc gctcagcctg aagagcagag aatgccatgg gtgggactgt gggggtcgga     3120

tcgtggggtt gttggcagag ggcaaccctg ggccccacac cgtgtggaca ggcagacacc     3180

agattgtcca ggagcaggag ctgctgggac tgcgctggcc ccggacctag tgggccttct     3240

cctggctgct gagatgtcgt ctgtgactgg cctggctgga gggggagtgt tgacaaccca     3300

aagctgttct ccagtctggg gagggagagg cagggtcccc aatgtccgag ctgcatctgg     3360

acgctgctct taaaggacct cctggggcag gggagcggta gggtctggac tgggcagatg     3420

ctgtatgacc tccctgagca cccgtgactg ccccatgctt tcccctttgt gctctgtgtg     3480

tgtctgggct gtgcccgggg gcttcacaaa taaagtcgtg tggcagcttc a              3531


<210> 2616
<211> 2440
<212> DNA
<213> Homo sapiens

<400> 2616
caattcggga gcccgttctc gcgggatttt ccaagaccgg gttggaattt gcgggggtta       60

ggagacggaa gtcagagcct aggaagattt gggggtcgcc ttgccggcct cctgtcctcc      120

tccggcggcg gcggagcccg agagaactag gtgaacaccg ctttgccagc ctcacacagc      180

gtcccctggc tctgccgccg ctccggacgt cgccctcccg ttctgcttgg gtccccttag      240

tcgctacctt tgctgggatc cccctcctcc atcctgtggc ttcgggttgc cgaagagcga      300

tgctcggagg gcggccggaa gtggcgttgg ccgccattgg cctgccggcc agccaccttg      360

ctgtcctccg ccgccttccg ggtgttacat gcagccgggc tcggcccctc cccctggccg      420

gatggatccg tcggcgccac agccccgcgc ggaaacctca ggcaaagaca tatggcatcc      480

aggagaaaga tgtcttgccc cttctccaga taatggaaaa ctttgtgaag caagcataaa      540

atctatcaca gtggatgaaa atggcaagtc atttgcagtc gtcttatatg cagattttca      600

agaaaggaaa atacctctta aacagcttca agaagtgaaa tttgttaaag attgccctag      660

gaatcttata tttgatgatg aagatttaga aaaaccttat ttcccaaacc gaaaatttcc      720

atcatcttct gttgctttta aattatctga caatggagac tctattcctt ataccatcaa      780

taggtatttg agagactacc aaagagaagg aacccggttt ctttatggac actacatcca      840

tggaggaggg tgcattctgg gtgatgacat gggacttgga aaaacagtac aggttatttc      900

atttctggct gcagttttgc ataaaaaggg aactcgtgag gatattgaaa ataacatgcc      960

agagttttta ctaagaagta tgaaaaagga acccctttct tctacagcaa aaaagatgtt     1020

cttaatagtt gctcctcttt ctgtcctcta caactggaag gatgaattgg acacctgggg     1080

atatttcaga gtcactgttt tacatggaaa cagaaaagat aatgaattaa ttcgtgtaaa     1140

gcagaggaaa tgtgaaattg ctctaacaac ttatgaaaca ctacgcttat gcctggatga     1200

acttaacagt ttggaatggt cagctgtcat tgtggatgaa gctcatagaa tcaagaatcc     1260

aaaagctaga gtaacagaag ttatgaaagc tttgaaatgt aatgtccgca ttggcctcac     1320

tggaaccatc cttcagaaca acatgaagga actgtggtgt gttatggact gggctgtgcc     1380

aggcctttta gggagtggga cctacttcaa gaagcagttt tctgacccag tagaacatgg     1440

tcagagacac acggcaacaa agagagaact agccactggc cgaaaggcca tgcaaagact     1500

tgccaaaaag atgtctggct ggtttctcag gcgcaccaag actcttatca aggatcagtt     1560

gcctaagaag gaagaccgga tggtgtattg ttctttgaca gatttccaga aagctgtcta     1620

tcaaacagtg ttagaaacag aggacgtgac tttgatactt caatcttctg agccttgtac     1680

ctgtaggagt ggccaaaaaa ggagaaattg ttgttataag accaattctc atggtgaaac     1740

agtgaaaacc ttgtatctca gttaccttac agtccttcag aaggtagcta accatgtcgc     1800

gctactgcaa gctgctagta cttccaaaca acaggaaaca cttatcaaaa ggatatgtga     1860

tcaggtattt tccagattcc cagattttgt gcagaaaagc aaagatgcag cctttgaaac     1920

actttctgac cctaaataca gtggaaaaat gaaggtcctt cagcagcttt taaatcattg     1980

caggaaaaac agagataaag ttcttctctt ttctttttcc accaagttgc ttgacgtgct     2040

acagcagtac tgtatggcgt ctgggcttga ttaccgacga cttgatggaa gtacaaaatc     2100

agaggaaaga ctcaagattg taaaagagtt caacagtaca caagatgtta acatttgcct     2160

tgtctctaca atggctggtg gactaggcct caattttgtc ggtgccaatg ttgttgtatt     2220

atttgatcct acttggaatc cagccaatga tcttcaagcc attgacagaa cccaaacaca     2280

ttgtaggaga gaaagggatg ctgagcccct ctcctctgct cctgggttgc agaatggaag     2340

tgagaatgca gtaccttacc cctggtggtg ctgtgtcaca ggagcctcca tttcctgctg     2400

gagatgtgag atttgcagga tccaagatgt cctcgagtaa                           2440


<210> 2617
<211> 6932
<212> DNA
<213> Homo sapiens

<400> 2617
attctccagc aggcctgctt ctggagttgg gagatgtcag cctgctggga gggggtgggg       60

ggaggaggaa gaggtggggc tctactctga ttaattacct taggcattca ggggtggggc      120

ttccttcagc catctgcctg agatatggga gggagctgga gaaagaagga gggggagaga      180

ctgccagaga ggaagagaaa agaaaggaag aaacattaga aagaaaaagg aaggaaaacg      240

gtataaagag agatcaatta cccaccctta aatagctaga ttgggggggg aggggggtgg      300

aaaagaaagc tgtggaggtg tgccccagca cggctgcttt gaaaggttta tcatctatcc      360

gtttggttta tggagaaaaa gaaaatggta actcagggta accaggagcc gacaacaact      420

cctgacgcaa tggttcagcc ttttactacc atcccatttc caccacctcc gcagaatgga      480

attcccacag agtatggggt gccacacact caagactatg ccggccagac cggtgagcat      540

aacctgacac tctacggaag tacgcaagcc cacggggagc agagcagcaa ctcacccagc      600

acacaaaatg gatctcttac gcagacagaa ggtggagcac agacagacgg ccagcagtca      660

cagacacaaa gtagtgaaaa ttcagagagt aaatctaccc cgaaacggct gcatgtctct      720

aatattcctt tccgcttccg ggaccctgac ctccggcaga tgtttgggca gtttggcaaa      780

atcctagatg tagaaataat ctttaatgaa cgtggctcta agggattcgg gttcgtaact      840

ttcgagaata gtgctgatgc agacagggcc agggagaaat tacacggcac cgtggtagag      900

ggccgtaaaa tcgaggtgaa taatgctaca gcacgtgtaa tgaccaataa gaagatggtc      960

acaccatatg caaatggttg gaaattaagc ccagtagttg gagctgtata tggtccggag     1020

ttatatgcag catccagctt tcaagcagat gtgtccctag gcaatgatgc agcagtgccc     1080

ctatcaggaa gagggggtat caacacttac attcctttaa tcattcctgg cttcccttac     1140

cctactgcag ccaccacggc agccgctttc agaggagccc atttgagggg cagagggcgg     1200

acagtatatg gtgcagtccg agcggtacct ccaacagcca tccccgccta tccaggggtg     1260

gatatgcagc ctacagatat gcacagcctg ctactgcaac cgcagccacc gctgctgcag     1320

ccgctgcagc cgcttacagt gacggttatg gcagggtgta cacagccgac ccctaccatg     1380

cccttgcccc tgccgctagc tatggagttg gcgctgtggc gagtttatac cgaggtggct     1440

acagccgatt tgccccctac tgaagtgacg tgagacccct gcaaatggga cagcccccca     1500

gttcatgagg cctggctatt gcaatattta ctagtagagg aactctatag caagatgaag     1560

aggaaaaaca aacaaacaaa caaaaaaaaa cacaaaaaaa gaaagaatac ttttttatac     1620

ctcactatgt tctttgaata tgtatttttc ctttaaattt ctgcctttaa ttcttttgtt     1680

ccaaagattg tgcatttttt tctttttttt tttaaactgt ggtaaaaaaa aaaaaaataa     1740

tgcatttcca tgtctgtatg tccgtgctta gcttattcta tcaatcacgg aagaggcagt     1800

caaggaggaa ggagagacat taggagccga taaatgcatc tgatcagaaa tcagcagaca     1860

gaattaccaa agtgtatctg gtgctgaatg actgggggac aagcagaagt ggaagagatc     1920

tttctgcaac aggatattct tctagtcttc tgagtttctg gtctttgaca ggcaattctg     1980

gttggctgtg gctggaatcc acatgctgat agataggaat ttgtgcttac aaagcaggag     2040

aattaaaaag acgctttcct ctcctcttcc ctcctgtctt ctccgttctt tttacaatca     2100

tcttacacgc acagcctgag acagctggca tagtttttgg aattatagta ttgatatttc     2160

caaacgtgct ctcagacagt ggataataaa cacctcatta ggaaaccgat ctcagaatga     2220

actctggagt atgaaaaaga tcatttcttt ttgttcctgt aacctagcat tccttctagg     2280

cttcttctcc tttaattgaa ccacagctta gctcatgtat tcttttatta acaccctgct     2340

ctcatgtcca taagattcag gaatttagga cccagggaca gaaaagtgaa taagccagtg     2400

accagatttc ccccagatgt cttgaggatt agaagtacaa attgttgaca gccattaaag     2460

agggtgagga agggaaaagg aatattagaa gatctggtat ttcttacttt tttcttgcct     2520

cagaaagtac aaagtttaaa aaatagaata aagaatctgc tggggaaaga tagagtacca     2580

ggtcctaggt cagtagtccc tggaagtttt ggtgatgagg acatggaagg gcaggcagag     2640

gcactttgta cttgctccaa agccatagga attttcatct tccagagcct ttatgagtca     2700

cttctctatc cacagtcttg agcctgtggc tatcccgctg agcttctcac tgtcctccaa     2760

aaacaccccg ctgagcaccc ggaccacttt gtacacatta acactacagg acataaaatg     2820

cagaggccct gagattgctg ccctcccata ttggaaggag ggtctgcgat ggcaagggtc     2880

ttctatatca ccagaaagag tcgcgcagtg agtcactgcc gttgccatct ggctgtaatt     2940

ttctatgtta tcaaggtagg agggagtgtt tctcttctag ctgttagata gaactgataa     3000

aagcaagtgt cctacagcat ttcccaaatg aaggcattag gaaatagaaa agcacggtct     3060

ttttggctcc ctggtctagt cacattggta ctagggtgac ctttcaccca agggacagct     3120

gctaaaggga gtaattcaga gacatggagc ttctggttat gggtttgttt tgggtttgtt     3180

tttaactcct gcctccacac atgttcttga ctgataactg actcatgtcc ctgaattaaa     3240

atgactgacc tatgacagca tcaagcattc tttgtaagca gagtgatata tctgagaggg     3300

cgttgacctg ttgtgtagaa tacatatcct ttcccccttc agaatcctgt ctcgcctcgt     3360

aactgggaga gaggctgtgc ctgaaactag gggcgatgtc aaggaagcta gaggcctcga     3420

tgcaattatt actgactctg gggaggaaga cagagaataa ggggacacca actgcccagt     3480

ccactggcca tttttaaggg tccccccacc ccaagccaaa gtttggtttg ttgctgttaa     3540

gacaattttt gttgtatgta tataaatatt ttagttagag gagcggggaa tgggatgcgg     3600

gctttcacag ttctagggaa tgggggcagg gaggattttg cttttgcttt tgctttgagg     3660

gagaacttta gctgactaaa aaaacagaag tttggggtca tgatcacaaa ggggccattc     3720

ccaaaagatg gcaagccacg tattcagtgg agactaggcc aaattctaaa tggttttatc     3780

catagcaggg gagaatagga gaatgagttt aagagttttt ctcttctttt ttcctagaaa     3840

gaggtaagga taatgggaaa ggtagagaag gcggctccca cagacctttt aagagaggca     3900

gaatcttgag cttgaggcac cttgagtgca tctcagttca gctggttctg gctgaggcct     3960

ccaaaggcaa gctctgtgct ttccagtggt ttctgctgca tttccaggga tggtgtttaa     4020

caccgcttcc tccagctccc ttttctaaga aagaataaat ggagttctgc tttttatgaa     4080

agggtctttg gttttcagtg tcaacactga gaattggggc tcttgcaagc atctggattt     4140

cacagtatca acctccccgt caccttttga actttgagac tccgtacggt caacttcacc     4200

agaggcaggt tgctcgaagc agcactgctt gtctgttcct gactctggtt ctcactgtat     4260

taaaaaagag agtcagagga gtctggcatt tcgtgagttt gttagaggat gctggctgat     4320

aattccagaa aacttactga tgctaaatca cagtacatgc atgattcttt ttcagcttta     4380

ctatagttca tgacctggac tttctgtact cttggaagct gggctcctta aaggaggcct     4440

ctagtgaaca cctttatctc catgtccctc ttagagccca gagagctgcc cataggcatt     4500

ttccagaatt cctcatgtca cctagttcaa tttccattaa ctcagatcag ccattgtgat     4560

tcaccatttg tcaggctctc aggtttaaca aaacctacta tcaccatcat ccttcaacag     4620

ccacagtctg aattgagcca acattttttt ttctttgaga aagaagtgga ctggggcaca     4680

acttttagtc tgaggggagc tagtggaaat ctagacaata gaagtcatcg atagcagctt     4740

ttcctcaaat gtgtgactcc tcaggggcta aactgctctt agcttagaat tatgctttac     4800

tagagatcta gcagataagt gggttaatca ctaccatcct gtaactagtt atatagcttc     4860

cagacatgag ggagacatca aacagggatg gaagcaaccc caaggatatg caagaagggc     4920

atgatgaacc cccttccctc tggcaggaga acaaggccaa ccaagggaca gactggaaag     4980

cacttagatg tttaaggagg agaaagggga agctttgacc agtccttgcc ttttgccaag     5040

ttcagccagt tctccgctgc ttgcaacctc tagcgcagta acatttgcag aattgcagat     5100

tttcccccag atactaggag gaaagggact ttggggggtg gggaaggggt cgtggtgttt     5160

taaaagcata agttacctgt ttgcactgtt ttaagatagg aaaaaaaaat agtgggcaag     5220

gtgaacatca gacgtaaatt tgtgtgtttt tattttgtca tgctcttgaa aatgtttgac     5280

catttgtagt atacacagtg aaacttgatt ctctgttgca taaaacacta tatttttttg     5340

gaaatgttac tgtccaaaag cctcttccct ccctttcctt ttcctatgta cttccttcat     5400

acttgcttta ctgatcagcc aggcaatagc catccaagag ctagagcatg aaacagggcc     5460

ctttccaagt aggctctggg tgtcctaagc cagcgtgtgc cctctggttt agtgagtgta     5520

atagagtccc tggcaccttt ctttgcaaat gaggctaaca gaccagactg cagcaagtta     5580

tcagattcct caatcagatg cactaggagt gaggagccca gggatggagg gggttcctga     5640

agtattgcag ttggctgtag tagctgagtt cttttccatg ttaccgaaac tgtagccagt     5700

tacagtttac tcaggaaaac ggtagatcaa ttcagccatg gtagtgctgg ttggcaggga     5760

ttggtaacgg agagaactgc tcatcagcca aaactcaagc cttgcctttt aggaggccac     5820

cagcagaggg acttggtcct ccttgtctgg tacttgtgta catgccggtg acctgaggac     5880

tccactcaca ctggcgagca aaaagggagc agtgattctc ttttctctcc ccaccccctg     5940

ccctttgtta ccaacaccag tttcccaggg ggtacatgag tttctgaatt tttaaaaaat     6000

gtttttggtt tggtttttct ggggactgat aagtgcttta agcaatgtcc ataccccgtc     6060

aagactccca gcttagtcat tttcttgtat ttttctgttc acagtatttg tgtgtgtgct     6120

tgttttggca gctcattttg gctgtattat atattgagtg atgaattgat cctctttttt     6180

ccctaaggga tatgaattgt ttttcttgtg ttatattctg cttgtgaata gctggagcaa     6240

acctggggct gacacgcgta agctagggct gcaaagcgag aagagagccg gtggagtgta     6300

cttgtccctg acaggctgac ctacctgagt ctctgagctt ttcagtccaa atctttgcaa     6360

ggctcaaaat gccacagaac ctctcctctt ctccccactc cccatggcag ggaccggacc     6420

atccctacat gcaacatgct gttcctccag cccctcccat tgccatggca aaacaggtac     6480

ctttggggca tgggggcatt acatgggatg cttgtgtaat cgaccaccta gccttctctc     6540

tcccctcccg tcctccccca gaatcacttc ctaggacacc cgagctgctt gcccagggtc     6600

ctgtttccct gctaactcca gagaagcatc ccagggcttt gtgacagtct ctaattccct     6660

tcccttctcg ttaagaatca tattgtatag tagctttcag accatacagt attcattggg     6720

ttactcctat tattatcaag tagctggaat tgtgaaggtc ggagtagtta gatctttagc     6780

ttttattcct tatttttttg tattactctc catgtgtata aattattgat catgttgctg     6840

gcttttataa actctaagcg aaggaggagc actgcctcag cctttgcaca tggtaatgaa     6900

gcactgtttt taaataaaag agagaaacac ca                                   6932


<210> 2618
<211> 3469
<212> DNA
<213> Homo sapiens

<400> 2618
ctttccccgt cacctgcctg gaacaggggt gcggggcgag gagggcgtgg cgcccgtgtg       60

cgccttctgc ctgccccctc ggccttcttc acttagcctt cgacggccga gcgccccagg      120

ggtggcggtg ggagtggggt tgttgagcgg cgctggctcc tttcacaaat ggggaaactg      180

aggcttaaag ggcgtctgac tcgccagagc agctcagcct gcagctgcta gcagtggcgt      240

ctcatattag cattgttgtc aaccggaggc ggtgcgagtc cgccggggat tccagatggg      300

gctcctgcgc cgcccgccta tcatttgcgg cctgtattcg cgcgtcgctc ccgcagagcc      360

acctcccagc aggcccacgc ccgcgggggc cccgggctgg cgccgctgtc cctggaatcg      420

atagacggtc tccttctgtc acccaggctg gagtgtagtg gaacgatcac cgctgaactg      480

cagcgtcggc ttcctgggct caagcgatcc tcccacctca acctcccaag tcatggggac      540

tacagatgcc atcacacctg gctaattttt aaatttttct gtggagacag ggtctcattc      600

tgttgcccag gcttgtctcg aaccctggtc taaagtgatc ttcccgccta gcctcccaaa      660

atgttggaat tacagtctgc agatctccag gggagcccac cagcctagtc aacatggcct      720

cggaagacat tgccaagctg gcagagacac ttgccaagac tcaggtggcc gggggacagc      780

tgagtttcaa aggcaagagc ctcaaactca acactgcaga agatgctaaa gatgtgatta      840

aagagattga agactttgac agcttggagg ctctgcgtct ggaaggcaac acagtgggcg      900

tggaagcagc cagggtcatc gccaaggcct tagagaagaa gtcggagttg aagcgctgcc      960

actggagtga catgttcacg ggaaggctgc ggaccgagat cccaccagcc ctgatctcac     1020

taggggaagg actcatcaca gctggggctc agctggtgga gctggactta agcgacaacg     1080

cattcgggcc cgacggtgtg caaggcttcg aggccctgct caagagctca gcctgcttca     1140

ccctgcagga actcaagctc aacaactgtg gcatgggcat tggcggcggc aagatcctgg     1200

ctgcagctct gaccgaatgt caccggaaat ccagtgccca aggcaagcct ctggccctga     1260

aggtctttgt ggctggcaga aaccgtctgg agaatgatgg cgccactgcc ttggcagaag     1320

cttttagggt catcgggacc ctggaggagg tccacatgcc acagaatggg atcaaccacc     1380

ctggcatcac tgccctggcc caggctttcg ctgtcaaccc cctgctgcgg gtcatcaacc     1440

tgaatgacaa caccttcact gagaagggcg ccgtggccat ggccgagacc ttgaagacct     1500

tgcggcaggt ggaggtgatt aattttgggg actgcctggt gcgctccaag ggtgcagttg     1560

ccattgcaga tgccatccgc ggcggcctgc ccaagctaaa ggagctgaac ttgtcattct     1620

gtgaaatcaa gagggatgct gccctggctg ttgctgaggc catggcagac aaagctgagc     1680

tggagaagct ggacctgaat ggcaacaccc tgggagaaga aggctgtgaa cagcttcagg     1740

aggtgctgga gggcttcaac atggccaagg tgctggcgtc cctcagtgat gacgaggacg     1800

aggaggagga ggaggaagga gaagaggaag aagaggaagc agaagaagag gaggaggaag     1860

atgaggaaga ggaggaagaa gaggaggagg aggaggaaga agagcctcag cagcgagggc     1920

agggagagaa gtcagccacg ccctcacgga agattctgga ccctaacact ggggagccag     1980

ctcccgtgct gtcctcccca cctcctgcag acgtctccac cttcctggct tttccctctc     2040

cagagaagct gctgcgccta gggcccaaga gctccgtgct gatagcccag cagactgaca     2100

cgtctgaccc cgagaaggtg gtctctgcct tcctaaaggt gtcatctgtg ttcaaggacg     2160

aagctactgt gaggatggca gtgcaggatg cagtagatgc cctgatgcag aaggctttca     2220

actcctcgtc cttcaactcc aacaccttcc tcaccaggct gctcgtgcac atgggtctgc     2280

tcaagagtga agacaaggtc aaggccattg ccaacctgta cggccccctg atggcgctga     2340

accacatggt gcagcaggac tatttcccca aggcccttgc acccctgctg ctggcgttcg     2400

tgaccaagcc caacagcgcc ctggaatcct gctccttcgc ccgccacagt ctgctgcaga     2460

cgctgtacaa ggtctagact caaagcctct cccatccctt ggcctggacc agtgagctgg     2520

ggagggactc ggatgaactg aggcgcagcc tacgccattg ccttggacag gactctggcc     2580

acaggcaggg cgggtctgtg tcccatgtgt cctgtcagtc ccctgagtat gtgtgtgggt     2640

gtggcgcatg tgcaggtctg tgcctcctgt cgggatttgg gttttaacgt cttctgctgg     2700

cccagccctg ctctgttgtg gggagttggc ccccagggga aagggctgtg agctgctccg     2760

ccattaaact cacctccacc tgagggcgct ctgctgatct ccgcctgggc cctgatggcc     2820

gtccccaccc acctgccttc cggcccggct ccctggcgga gccagaaccc agggagttgc     2880

ccgcgtgctg tccttcccct ctgtgttgtg attgggttgt ttcctgccct gcctggggct     2940

gcttctcgtc accaagccct ggtcctgcgg cagctgtcac ccctaccatc cataccactg     3000

tgctgaccgc tcagcctgaa gagcagagaa tgccatgggt gggactgtgg gggtcggatc     3060

gtggggttgt tggcagaggg caaccctggg ccccacaccg tgtggacagg cagacaccag     3120

attgtccagg agcaggagct gctgggactg cgctggcccc ggacctagtg ggccttctcc     3180

tggctgctga gatgtcgtct gtgactggcc tggctggagg gggagtgttg acaacccaaa     3240

gctgttctcc agtctgggga gggagaggca gggtccccaa tgtccgagct gcatctggac     3300

gctgctctta aaggacctcc tggggcaggg gagcggtagg gtctggactg ggcagatgct     3360

gtatgacctc cctgagcacc cgtgactgcc ccatgctttc ccctttgtgc tctgtgtgtg     3420

tctgggctgt gcccgggggc ttcacaaata aagtcgtgtg gcagcttca                 3469


<210> 2619
<211> 3294
<212> DNA
<213> Homo sapiens

<400> 2619
ctcgccagcc gcgggttcgg gcgtcttcgg accagcgggg cgccgcaggc ccctcgcagc       60

gtccgtcggc aggcgggcag acgggcgggg gagtcgcccc ggcggggcaa gtccgtaccg      120

cgacatgggc gcgccgagca cgtccgtacc gcaagatggc tgctcggacg gggacagagc      180

tcgcctctgc cgcctcgaca actgctcctg ggtcctctaa gaggaggaag cgccacccat      240

ggcacacagt gtcccgtcgg acagcagaac cagccgtcgt cccacgacac gaccccatgc      300

cgcccgcagg gcgccccggg gctcgcgtcg gcccggccgt acgccaaaat ggcggctccc      360

gcgtatttcc gctcgcgcgc cgtatcgtct tcgccgcctg cgccggcaca cctattggcc      420

cccgcggcgt cccgtcgccg cgtcgcgttg ctggcccgtc ggagcgacgc cgctcgggtc      480

agtcggcggc cggactggga agatggacgc agctactctg acctacgaca ctctccggtt      540

tgctgagttt gaagattttc ctgagacctc agagcccgtt tggatactgg gtagaaaata      600

cagcattttc acagaaaagg acgagatctt gtctgatgtg gcatctagac tttggtttac      660

atacaggaaa aactttccag ccattggggg gacaggcccc acctcggaca caggctgggg      720

ctgcatgctg cggtgtggac agatgatctt tgcccaagcc ctggtgtgcc ggcacctagg      780

ccgagattgg aggtggacac aaaggaagag gcagccagac agctacttca gcgtcctcaa      840

cgcattcatc gacaggaagg acagttacta ctccattcac cagatagcgc aaatgggagt      900

tggcgaaggc aagtccatag gccagtggta cgggcccaac actgtcgccc aggtcctgaa      960

gaagcttgct gtcttcgata cgtggagctc cttggcggtc cacattgcaa tggacaacac     1020

tgttgtgatg gaggaaatca gaaggttgtg caggaccagc gttccctgtg caggcgccac     1080

tgcgtttcct gcagattccg accggcactg caacggattc cctgccggag ctgaggtcac     1140

caacaggccg tcgccatgga gacccctggt acttctcatt cccctgcgcc tggggctcac     1200

ggacatcaac gaggcctacg tggagacgct gaagcactgc ttcatgatgc cccagtccct     1260

gggcgtcatc ggagggaagc ccaacagcgc ccactacttc atcggctacg ttggtgagga     1320

gctcatctac ctggaccccc acaccacgca gccagccgtg gagcccactg atggctgctt     1380

catcccggac gagagcttcc actgccagca cccgccgtgc cgcatgagca tcgcggagct     1440

tgacccgtcc atcgctgtgg ggtttttctg taagactgaa gatgacttca atgattggtg     1500

ccagcaagtc aaaaagctgt ctctgcttgg aggtgccctg cccatgtttg agctggtgga     1560

gctgcagcct tcacatctgg cctgccccga cgtcctgaac ctgtccctag gtgagagctg     1620

ccaagtccag attcttctga tgtagagcga ctggaaagat tcttcgactc agaagatgaa     1680

gactttgaaa tcctgtccct ttgaaaatcc tggggtcggg ggtggcacct gtgagagcct     1740

ggggctcctg gtgccgctgc gtttcatcca tcccgcccgc tcgcctgccg agggctgcgc     1800

cccgtgctgc ctccccccag agggccaccc gctgtgctcg tggactgagg ctgcgctgcc     1860

cgggaggcct tactgcttgg tgtcagactg cccagctcag agtgcccgtc agggcctgtg     1920

catccgcacg cggagccgtc tgttaggagc ttccagagtg ttctctcgac actgccagcc     1980

ccgtgttagc acctgggcct cagtcccact tgctcccagg cgccggttct gtggttggtt     2040

tggaattaaa gtcctgtttg aagttgtcag acacagacat gaatttctgg gcgctccctg     2100

agtcagagtc tcagaagacc tgtgcaggct ggcgtgagag gagcggcagc cacactgcgg     2160

ccccacgccc aaggactggg ctgctctcga ggggggcgcg cccaccgctg tgtcctctct     2220

gcccagcctg gcttaccaag ggctacctca gtgggagatg aggttggagg aacgaaggcg     2280

aggttcctcc ttgctttggg gagaaaagta ttcaggaagt gggtgtgtgg gaaacctgaa     2340

gatggcgtgc acaggacaca gcgtgggcgg cctgggcaga agggcggctg gctgtcctgg     2400

agctgctgct ggagcctgcc ctcagagtgt ccctttccag tgctgtggca ttctgtggca     2460

gcttccccag gtgtggtgac gggggggggg cggggcctcc acctgtgaca gccaggcttg     2520

agggtggacg gcgtgcctct cccaggagcc ttccccatgt ccttgccttg ctgagaattg     2580

ccctcccatg ccgctgaggt gttaggtggt ttagggccaa aaggggaaaa ccacttgagt     2640

cttgtggtgt gtggtgggca gacaccacag ggtggcatca cctggtggca tttccagaac     2700

ctcagccccg attccagcac ccaccaccgc ctgaccctgt gtaacctgct gtcccgggtc     2760

ccagagtgca ctctgccccg ctgctctgct gcctgtcctg ggaaagtatc tttgccccac     2820

taggaaatgt aaacaggagg gcttggggag cgtgggcact tttctcatga gcagctactg     2880

cggcgttggc aggactcgct gctgctgctg ctgcttgtgt aggtcgggga gccagagatc     2940

cccgaggacg cgcgccggac agtcggcact gaccggccca cctggtagca gaggacaccc     3000

ccagcccccc aagcattgaa gacatagtgt atttcctcgt atcctttctc ccttgggtgt     3060

agttggggtg gggaagcagg gaaggctggt gcgatctcca ttccttgggc tccacgtccg     3120

agttcatggt gcgccgctgt gctgggagct gcagtggtaa tgtgtgggac accttgacca     3180

aaggggagct ttgtctcgtg tgttttgaaa aaggcttaat gaagagaatg ttgttcattc     3240

ttagtagtat agtttgcaat tcttaatggc aaataataag tttcagtaga aaac           3294


<210> 2620
<211> 2248
<212> DNA
<213> Homo sapiens

<400> 2620
ggtgggcccg cggaggaaag atactgggga gtgggagccg cggggttcag agcgatgatt       60

cccccacagg aggcatccgc tcgacggcgg gagattgagg acaagctgaa gcaggaggag      120

gagactctgt ccttcatccg agacagcctg gagaagagcg accagctcac taagaacatg      180

gtgtctatct tatcatcctt tgagagccgc cttatgaagc tggagaactc catcatccct      240

gtgcacaagc agacggagaa tctgcagcgg ctgcaggaga atgttgagaa gacgctgtcc      300

tgcctggacc atgtcatcag ctactaccat gtggccagtg acactgagaa gatcatcaga      360

gagggcccca caggtaggct ggaagagtac ctgggaagca tggccaagat tcagaaggca      420

gtggagtatt tccaggacaa cagcccagac agcccggaac tcaacaaagt gaaactgctc      480

tttgagcgcg ggaaggaggc cctggagtcc gaatttcgca gcctgatgac gcggcacagt      540

aaggtcgtct cgcccgtgct catcttggat ctgatcagtg gtgacgatga tctggaggcc      600

caggaggacg tgaccctgga gcacctgccc gagagcgtgc tccaggatgt cattcgcatc      660

tcccgctggc tggtggaata tggccgcaac caagatttca tgaacgtcta ctaccagata      720

cgctccagcc agctggaccg ctccatcaaa ggactgaagg agcatttcca taagagcagt      780

tcttcctctg gggttcccta ctcccctgct atccccaaca agaggaaaga cacacctacc      840

aagaagccag tcaagcggcc agggacgatc cgtaaggctc agaaccttct gaaacagtat      900

tcccagcatg gtctagatgg gaaaaagggg ggctctaacc tcattcctct ggaaggtcac      960

gagcatgatt tccgagttaa gcacctgtcc gaggccttga acgacaagca cgggccgctg     1020

gccgggagag atgacatgct ggacgtggag accgatgcct acatccactg cgtcagtgcc     1080

ttcgtcaagc tggcgcagag cgagtaccag ctgctggccg acatcatccc cgagcaccac     1140

cagaagaaga ccttcgactc cctgatacag gatgccctgg atgggctgat gcttgaaggg     1200

gagaacatcg tgtctgctgc ccggaaggcc attgtgcgac acgacttctc cacggtgctc     1260

accgtcttcc ccatcctgcg acacctcaag cagaccaagc ctgagtttga ccaggtgctc     1320

cagggcacgg ctgccagcac aaagaacaag ctgcctggcc tcatcacatc catggagacc     1380

atcggtgcca aagcgctgga ggacttcgca gacaacatca agaatgaccc ggacaaggag     1440

tacaacatgc cgaaggacgg caccgtacac gagctcacca gcaatgccat cctcttcctg     1500

cagcagcttt tggacttcca ggagacggca ggcgccatgc tggcctccca agagaccagc     1560

tcttcggcca ccagctacag ctctgagttc agcaagcggc tgctaagcac ctatatctgt     1620

aaagtgctgg gcaacctgca gttgaacttg ctgagcaagt ccaaggtgta cgaggaccca     1680

gctctgagcg ccatcttcct gcacaacaac tacaattaca tcctcaagtc cctggagaag     1740

tctgaactga tccagctggt ggcagtgaca cagaagactg ctgagcgctc ctaccgggag     1800

cacattgagc agcagatcca gacctaccag cgcagctggt taaaggtgac tgattacatc     1860

gcagagaaga atctacctgt gttccagccg ggagtcaagc tccgggacaa ggagcggcag     1920

attatcaagg agcgttttaa gggcttcaat gatggcctcg aagaactgtg caaaatccag     1980

aaggcctggg ctattccaga cacagagcag agggacagga ttcgccaggc ccagaagacc     2040

attgtcaagg agacctacgg ggcctttcta cagaagtttg gcagcgtgcc cttcaccaag     2100

aacccggaga agtacatcaa gtacggggtg gagcaggtgg gcgacatgat cgatcgcctt     2160

ttcgacacct ctgcctgagc ctgctgctag ccctgcctgg ttccaccaga ctggcgtgtc     2220

attggacaga taaaccagtg ttagcttg                                        2248


<210> 2621
<211> 1601
<212> DNA
<213> Homo sapiens

<400> 2621
cgctgctctt ggttctggtt ctggaggctg ggttgagagg tcgccggtcc gactgtcctc       60

ggcggttggt cagtgtgaat ttgtgacagc tgcagttgct ccccgccccc gagcagccga      120

ggagtctacc atggctcaag aatctcccaa aaattcagca gcagaaattc cagtgactag      180

taatggagaa gttgatgact ctcgtgaaca tagctttaat agggatttga agcattcatt      240

accatctgga cttggtctct cagaaaccca aattacatct catggctttg acaataccaa      300

agagggtgtt attgaagcag gagcatttca aggtggccag agaacacaga caaaaagtgg      360

accagttatt ctagcagatg aaattaaaaa tcctgcaatg gaaaagttag aacttgttag      420

aaaatggagt ctaaacacct ataagtgtac tcgacagatt atctctgaga agctaggccg      480

tggctcaaga actgtggacc ttgaacttga agctcagatt gatatattaa gggataacaa      540

gaaaaaatat gaaaatattt taaaactggc tcaaacattg tcgacccagc ttttccagat      600

ggtacatacc caaaggcaac ttggagatgc atttgctgac ctgagtttga agtcactaga      660

acttcatgaa gaatttggct ataatgccga tacccagaaa ctgctggcta aaaatggaga      720

gactcttctt ggggccatta attttttcat tgctagtgtg aacactttgg tgaataaaac      780

cattgaagat acattaatga ctgtgaaaca gtatgaaagt gccaggattg aatatgatgc      840

atatcgcact gatttggaag aactgaatct tggaccacgt gacgcaaaca ctctgccaaa      900

gattgagcag tcacagcatc tcttccaagc acataaggaa aaatatgata aaatgcgcaa      960

tgatgtttct gtcaaattga aatttctaga agaaaataag gttaaagtat tgcacaatca     1020

gctggtcctt ttccacaatg ccattgccgc ttactttgct gggaatcaga agcagcttga     1080

acagacactt aaacagttcc atatcaaatt gaaaacccct ggagtggatg ccccatcttg     1140

gcttgaagaa cagtaaaatc acagcggaaa ataaaaagaa agtcgcgttg ttatatttct     1200

aaaccaacct aacaagaatt aagcagagtt gggggaagtg ggaggggtga caagcattat     1260

agtgattctt gcacaaacag ctttaatttt tccctttttc atactttaac aattgaactg     1320

ttaagggtgg ttttaatgta aacatagttt ctataatctg aacacaataa ttttcctttt     1380

tgagaaatcc ttttgtattg tgagggttga tggctatttc tgtagtttga aaacatctaa     1440

tagagatttg cactgacaag ataaaaattc aaggtttttg gtcctggaaa tgagggccga     1500

ttgtaacttt tccaaaggga ggtttacatg atttgtatca acatcagata ttttatatgt     1560

gaatatatta aacatcttta agagattcat tttcatgtat t                         1601


<210> 2622
<211> 2011
<212> DNA
<213> Homo sapiens

<400> 2622
gtgcgcgcta catggccgga gtcgggcgaa gcgggggacc gtggggaaga acgcgaggag       60

ggaggagtgg gaggttgggg gtgtcgctag gcgcccttag ctccctccct ctggaggagc      120

tgccgcggcc actctgctgc cgccgctgcc gccgccattt tgggttcgct ttgcgagggg      180

aaacgatccc agtgtcggtt gcgggatccg cctcctctca gtttgcccct ttagccctcc      240

acctttccct tctcctctct cgcatttccg ccagtcggct tacccgctgg ccgcctcctg      300

acaagcggga gggatccgcg gtggacccag ggaagcggag gagcctggcg gccaccccct      360

cttcctcact tccctgtact ctcatcgctc tcggcctccg acacgaaaag gaagcaaatg      420

agctgatgga agatctgttt gaaactttcc aagatgagat gggattctcc aacatggaag      480

atgatggccc agaagaggag gagcgtgtgg ctgagcctca agctaacttt aacacccctc      540

aagctctacg gtttgaggaa ctactggcca acctactaaa tgaacaacat cagatagcga      600

aggaactatt tgaacagctg aagatgaaga aaccttcagc caaacagcag aaggaggtag      660

agaaggttaa accccagtgt aaggaagttc atcagaccct gattctggac ccagcacaaa      720

ggaagagact ccagcagcag atgcagcagc atgttcagct cttgacacaa atccaccttc      780

ttgccacctg caaccccaat ctcaatccgg aggccagtag caccaggata tgtcttaaag      840

agctgggaac ctttgctcaa agctccatcg cccttcacca tcagtacaac cccaagtttc      900

agaccctgtt ccaaccctgt aacttgatgg gagctatgca gctgattgaa gacttcagca      960

cacatgtcag cattgactgc agccctcata aaactgtcaa gaagactgcc aatgaatttc     1020

cctgtttgcc aaagcaagtg gcttggatcc tggccacaag caaggttttc atgtatccag     1080

agttacttcc agtgtgttcc ctgaaggcaa agaatcccca ggataagatc ctcttcacca     1140

aggctgagga caatttgtta gctttaggac tgaagcattt tgaagggact gagtttctta     1200

accctctaat cagcaagtac cttctaacct gcaagactgc ccgccaactg acagtgagaa     1260

tcaagaacct caacatgaac agagctcctg acaacatcat taaattttat aagaagacca     1320

aacagctgcc agtcctagga aaatgctgtg aagagatcca gccacatcag tggaagccac     1380

ctatagagag agaagaacac cggctcccat tctggttaaa ggtacagccc tcttcctcga     1440

agtctgtagg aggcagaagg tcactgaaag ttctgagaga atatcaagga cttccttaat     1500

cgtctaatgc tttagttgta gaactaggac ttcaggaatc ttcctgattc acctttcttc     1560

ccttactttt ctgcccttct ccgggtgatt ctacaacatt ttcaaaataa tgggtaaaat     1620

ggtaatttgc taaaggaaat tcagagaaga gtttctaaag tgtataattg gactgtggtc     1680

tttgtagaaa tttcatatgc agagtccctt ggaaagatgc cttgagcttg tctcaggtcc     1740

ctaaacttag aaagtcctat tctttttccc aaattctgac atgtgctgga tcagagtgtt     1800

ctcatttcca ataggccagt ctgccatcca tccaggaaga actgcggcac atggctgatg     1860

gtgctagaga ggtaggaaat atgactggaa ccactgagat caactcagat caaggcctag     1920

aaaaagacaa ctcagagttg gggagtgaaa ctcggtaccc actgctattg cctaagggtg     1980

tagtcctgaa actgaagcca gttgccgacc g                                    2011


<210> 2623
<211> 936
<212> DNA
<213> Homo sapiens

<400> 2623
taggccgggg ccggcggggc ccggaaggcg acgggaagga gccgagcttg ggttatggcg       60

gcgccgggcg cgctgctggt gatgggcgtg agcggctcgg ggaactggga tggaaattct      120

atgatgctga tgattatcac ccggaggaaa atcgaaggaa gatgggaaaa ggcataccgc      180

tcaatgacca ggaccggatt ccatggctct gtaacttgca tgacatttta ctaagagatg      240

tagcctcggg acagcgtgtg gttctagcct gttcagccct gaagaaaacg tacagagaca      300

tattaacaca aggaaaagat ggtgtagctc tgaagtgtga ggagtcggga aaggaagcaa      360

agcaggctga gatgcagctc ctggtggtcc atctgagcgg gtcgtttgag gtcatctctg      420

gacgcttact caaaagagag ggacatttta tgccccctga attattgcag tcccagtttg      480

agactctgga gcccccagca gctccagaaa actttatcca aataagtgtg gacaaaaatg      540

tttcagagat aattgctaca attatggaaa ccctaaaaat gaaatgacaa tgattttgta      600

tcagtggtcc aaacagaact aagcataaat cattgtgcca tcccaaacct cgttccagcc      660

gccttgccca tactagattc taaatgtttc taaaggcaaa ccccaatgtg tcaagacaga      720

cttgtttagg tgtaatttta ggaattatgc tggttcatca ggaagcagag ggggagtttt      780

aaaagtcaag cttaaattga agtttaaatt catctataac caaatcaaat gatcagagga      840

aattctgtaa tcaatgctgg aaatcgttac attgtttaga acattcttgc tcatgcctgt      900

atttgcacaa ataaatgaaa cttcgctgtc cttggc                                936


<210> 2624
<211> 631
<212> DNA
<213> Homo sapiens

<400> 2624
aaattctcgt caacgtccgg tgagggggca ggacttcctt gctggttgct aagacactct       60

tgtttcgctc cttgacaacc ctggcggggg ttcgctggct gcggccccgg ctccggcccc      120

cgcaggagca gcaccccccg gggaaagaca ttttctgctc ccaccgagtt ggcagggcct      180

gcttcctgaa tctcctgggt gtgtcttaac tgccagtccc agcacctcct gaaagcccca      240

ctctcctcca gtggtcacag tggaaggatc atgggagaaa cagaagggaa gaaagatgag      300

gctgattata agcgactgca gaccttccct ctggtcaggc actcggacat gccagaggag      360

atgcgcgtgg agaccatgga gctatgtgtc acagcctgtg agaaattctc caacaacaac      420

gaggtattgc cagcagtgca ggcggcccct cgtgcttttg atggcccctg tgggtgaata      480

aagtggcccc tgttccctgc agttggctcc agacagtact gctaggatga ggccagagcc      540

ttccttggaa gcattcagtc tggggaaagt cagtgagtga gaggctggcg ctgactccag      600

gcactgacgg tcacacccag ccctagagga g                                     631


<210> 2625
<211> 6746
<212> DNA
<213> Homo sapiens

<400> 2625
ttgtttgatg gttttgatgt ttcagattcg ttatatttca caaacacaag gcttgccagc       60

tgaatatctt ctcagtgccg gaacaaaaac aaccaggttt ttcaacagag atcctaattt      120

ggggtaccca ctgtggaggc ttaagacacc tgaagaacat gaactggaga ctggaataaa      180

atcaaaagaa gctcggaagt acatttttaa ttgcttagat gacatggctc aggtgaatat      240

gtctacagac ctggagggaa cagacatgtt ggcagagaag gcagaccgaa gagaatacat      300

tgatctgtta aagaaaatgc tcacaattga tgcagataag agaattaccc ctctaaaaac      360

tcttaaccat cagtttgtga caatgactca ccttttggat tttccacata gcaatcatgt      420

taagtcttgt tttcagaaca tggagatctg caagcggagg gttcacatgt atgatacagt      480

gagtcagatc aagagtccct tcactacaca tgttgcccca aatacaagca caaatctaac      540

catgagcttc agcaatcagc tcaatacagt gcacaatcag gccagtgttc tagcttccag      600

ttctactgca gcagctgcta ctctttctct ggctaattca gatgtctcac tactaaacta      660

ccagtcagct ttgtacccat catctgctgc accagttcct ggagttgccc agcagggtgt      720

ttccttgcag cctggaacca cccagatttg cactcagaca gatccattcc aacagacatt      780

tatagtatgt ccacctgcgt ttcaaactgg actacaagca acaacaaagc attctggatt      840

ccctgtgagg atggataatg ctgtaccgat tgtaccccag gcaccagctg ctcagccact      900

acagattcag tcaggagttc tcacgcaggg aagctgtaca ccactaatgg tagcaactct      960

ccaccctcaa gtagccacca tcacaccgca gtatgcggtg ccctttactc tgagctgcgc     1020

agccggccgg ccggcgctgg ttgaacagac tgccgctgta ctgcaggcgt ggcctggagg     1080

gactcagcaa attctcctgc cttcaacttg gcaacagttg cctggggtag ctctacacaa     1140

ctctgtccag cccacagcaa tgattccaga ggccatgggg agtggacagc agctagctga     1200

ctggaggaat gcccactctc atggcaacca gtacagcact atcatgcagc agccatcctt     1260

gctgactaac catgtgacat tggccactgc tcagcctctg aatgttggtg ttgcccatgt     1320

tgtcagacaa caacaatcca gttccctccc ttcgaagaag aataagcagt cagctccagt     1380

ctcttccaag tcctctctag atgttctgcc ttcccaagtc tattctctgg ttgggagcag     1440

tcccctccgc accacatctt cttataattc cttggtccct gtccaagatc agcatcagcc     1500

catcatcatt ccagatactc ccagccctcc tgtgagtgtc atcactatcc gaagtgacac     1560

tgatgaggaa gaggacaaca aatacaagcc cagtagctct ggactgaagc caaggtctaa     1620

tgtcatcagt tatgtcactg tcaatgattc tccagactct gactcttctt tgagcagccc     1680

ttattccact gataccctga gtgctctccg aggcaatagt ggatccgttt tggaggggcc     1740

tggcagagtt gtggcagatg gcactggcac ccgcactatc attgtgcctc cactgaaaac     1800

tcagcttggt gactgcactg tagcaaccca ggcctcaggt ctcctgagca ataagactaa     1860

gccagtcgct tcagtgagtg ggcagtcatc tggatgctgt atcaccccca cagggtatcg     1920

agctcaacgc ggggggacca gtgcagcaca accactcaat cttagccaga accagcagtc     1980

atcggcggct ccaacctcac aggagagaag cagcaaccca gccccccgca ggcagcaggc     2040

gtttgtggcc cctctctccc aagcccccta caccttccag catggcagcc cgctacactc     2100

gacagggcac ccacaccttg ccccggcccc tgctcacctg ccaagccagg ctcatctgta     2160

tacgtatgct gccccgactt ctgctgctgc actgggctca accagctcca ttgctcatct     2220

tttctcccca cagggttcct caaggcatgc tgcagcctat accactcacc ctagcacttt     2280

ggtgcaccag gtccctgtca gtgttgggcc cagcctcctc acttctgcca gcgtggcccc     2340

tgctcagtac caacaccagt ttgccaccca atcctacatt gggtcttccc gaggctcaac     2400

aatttacact ggatacccgc tgagtcctac caagatcagc cagtattcct acttatagtt     2460

ggtgagcatg agggaggagg aatcatggct accttctcct ggccctgcgt tcttaatatt     2520

gggctatgga gagatcctcc tttaccctct tgaaatttct tagccagcaa cttgttctgc     2580

aggggcccac tgaagcagaa ggtttttctc tgggggaacc tgtctcagtg ttgactgcat     2640

tgttgtagtc ttcccaaagt ttgccctatt tttaaattca ttatttttgt gacagtaatt     2700

ttggtacttg gaagagttca gatgcccatc ttctgcagtt accaaggaag agagattgtt     2760

ctgaagttac cctctgaaaa atattttgtc tctctgactt gatttctata aatgctttta     2820

aaaacaagtg aagcccctct ttatttcatt ttgtgttatt gtgattgctg gtcaggaaaa     2880

atgctgatag aaggagttga aatctgatga caaaaaaaga aaaattactt tttgtttgtt     2940

tataaactca gacttgccta ttttatttta aaagcggctt acacaatctc ccttttgttt     3000

attggacatt taaacttaca gagtttcagt tttgttttaa tgtcatatta tacttaatgg     3060

gcaattgtta tttttgcaaa actggttacg tattactctg tgttactatt gagattctct     3120

caattgctcc tgtgtttgtt ataaagtagt gtttaaaagg cagctcacca tttgctggta     3180

acttaatgtg agagaatcca tatctgcgtg aaaacaccaa gtattctttt taaatgaagc     3240

accatgaatt cttttttaaa ttatttttta aaagtctttc tctctctgat tcagcttaaa     3300

tttttttatc gaaaaagcca ttaaggtggt tattattaca tggtggtggt ggttttatta     3360

tatgcaaaat ctctgtctat tatgagatac tggcattgat gagctttgcc taaagattag     3420

tatgaatttt cagtaataca cctctgtttt gctcatctct cccttctgtt ttatgtgatt     3480

tgtttgggga gaaagctaaa aaaacctgaa accagataag aacatttctt gtgtatagct     3540

tttatacttc aaagtagctt cctttgtatg ccagcagcaa attgaatgct ctcttattaa     3600

gacttatata ataagtgcat gtaggaattg caaaaaatat tttaaaaatt tattactgaa     3660

tttaaaaata ttttagaagt tttgtaatgg tggtgtttta atattttaca taattaaata     3720

tgtacatatt gattagaaaa atataacaag caatttttcc tgctaaccca aaatgttatt     3780

tgtaatcaaa tgtgtagtga ttacacttga attgtgtact tagtgtgtat gtgatcctcc     3840

agtgttatcc cggagatgga ttgatgtctc cattgtattt aaaccaaaat gaactgatac     3900

ttgttggaat gtatgtgaac taattgcaat tatattagag catattactg tagtgctgaa     3960

tgagcagggg cattgcctgc aaggagagga gacccttgga attgttttgc acaggtgtgt     4020

ctggtgagga gtttttcagt gtgtgtctct tccttccctt tcttcctcct tcccttattg     4080

tagtgcctta tatgataatg tagtggttaa tagagtttac agtgagcttg ccttaggatg     4140

gaccagcaag cccccgtgga ccctaagttg ttcaccggga tttatcagaa caggattagt     4200

agctgtattg tgtaatgcat tgttctcagt ttccctgcca acattgaaaa ataaaaacag     4260

cagcttttct cctttaccac cacctctacc cctttccatt ttggattctc ggctgagttc     4320

tcacagaagc attttcccca tgtggctctc tcactgtgcg ttgctacctt gcttctgtga     4380

gaattcagga agcaggtgag aggagtcaag ccaatattaa atatgcattc ttttaaagta     4440

tgtgcaatca cttttagaat gaattttttt ttccttttcc catgtggcag tccttcctgc     4500

acatagttga cattcctagt aaaatatttg cttgttgaaa aaaacatgtt aacagatgtg     4560

tttataccaa agagcctgtt gtattgctta ccatgtcccc atactatgag gagaagtttt     4620

gtggtgccgc tggtgacaag gaactcacag aaaggtttct tagctggtga agaatataga     4680

gaaggaacca aagcctgttg agtcattgag gcttttgagg tttctttttt aacagcttgt     4740

atagtcttgg ggcccttcaa gctgtgaaat tgtccttgta ctctcagctc ctgcatggat     4800

ctgggtcaag tagaaggtac tggggatggg gacattcctg cccataaagg atttggggaa     4860

agaagattaa tcctaaaata caggtgtgtt ccatctgaat tgaaaatgat atatttgaga     4920

tataatttta ggactggttc tgtgtagata gagatggtgt caaggaggtg caggatggag     4980

atgggagatt tcatggagcc tggtcagcca gctctgtacc aggttgaaca ccgaggagct     5040

gtcaaagtat ttggagtttc ttcattgtaa ggagtaaggg cttccaagat ggggcaggta     5100

gtccgtacag cctaccagga acatgttgtg ttttctttat tttttaaaat cattatattg     5160

agttgtgttt tcagcactat attggtcaag atagccaagc agtttgtata atttctgtca     5220

ctagtgtcat acagttttct ggtcaacatg tgtgatcttt gtgtctcctt tttgccaagc     5280

acattctgat tttcttgttg gaacacaggt ctagtttcta aaggacaaat tttttgttcc     5340

ttgtcttttt tctgtaaggg acaagatttg ttgtttttgt aagaaatgag atgcaggaaa     5400

gaaaaccaaa tcccattcct gcaccccagt ccaataagca gataccactt aagataggag     5460

tctaaactcc acagaaaagg ataataccaa gagcttgtat tgttacctta gtcacttgcc     5520

tagcagtgtg tggctttaaa aactagagat ttttcagtct tagtctgcaa actggcattt     5580

ccgattttcc agcataaaaa tccacctgtg tctgctgaat gtgtatgtat gtgctcactg     5640

tggctttaga ttctgtccct ggggttagcc ctgttggccc tgacaggaag ggaggaagcc     5700

tggtgaattt agtgagcagc tggcctgggt cacagtgacc tgacctcaaa ccagcttaag     5760

gctttaagtc ctctctcaga acttggcatt tccaacttct tcctttccgg gtgagagaag     5820

aagcggagaa gggttcagtg tagccactct gggctcatag ggacacttgg tcactccaga     5880

gtttttaata gctcccagga ggtgatatta ttttcagtgc tcagctgaaa taccaacccc     5940

aggaataaga actccatttc aaacagttct ggccattctg agcctgcttt tgtgattgct     6000

catccattgt cctccactag aggggctaag cttgactgcc cttagccagg caagcacagt     6060

aatgtgtgtt ttgttcagca ttattatgca aaaattcact agttgagatg gtttgtttta     6120

ggataggaaa tgaaattgcc tctcagtgac aggagtggcc cgagcctgct tcctattttg     6180

attttttttt tttttaactg atagatggtg cagcatgtct acatggttgt ttgttgctaa     6240

actttatata atgtgtggtt tcaattcagc ttgaaaaata atctcactac atgtagcagt     6300

acattatatg tacattatat gtaatgttag tatttctgct ttgaatcctt gatattgcaa     6360

tggaattcct actttattaa atgtatttga tatgctagtt attgtgtgcg atttaaactt     6420

tttttgcttt ctcccttttt ttggttgtgc gctttctttt acaacaagcc tctagaaaca     6480

gatagtttct gagaattact gagctatgtt tgtaatgcag atgtacttag ggagtatgta     6540

aaataatcat tttaacaaaa gaaatagata tttaaaattt aatactaact atgggaaaag     6600

ggtccattgt gtaaaacata gtttatcttt ggattcaatg tttgtctttg gttttacaaa     6660

gtagcttgta ttttcagtat tttctacata atatggtaaa atgtagagca attgcaatgc     6720

atcaataaaa tgggtaaatt ttctga                                          6746


<210> 2626
<211> 3094
<212> DNA
<213> Homo sapiens

<400> 2626
gggcggacgg tcggagtccg gaagaaaaac agtccgcgac agctaggcgc gtgagaccgg       60

ccgcccgcag ggctgctctg gccgggaccc gctggccggg agacgcgaac ctgccggacc      120

accgcgcggg gacgacggcg gccatgagct cgcggaagct gagcgggccg aaaggcagga      180

ggctcagcac atacatcagg aggtctgcct gatcccatgg tgaaccccgg gaatccgaaa      240

tcagattgag ataagatcct ttagggaagt gacttagcct ggtctcttgc ctgctctttc      300

acggggaaca acgctaatcg cccacttagt ctaagtcacg atgcttggat ttgctgctaa      360

tcgtcggatt tgagagtggg aacaagaaat ccggactttt gctctccatc ctcttagaat      420

ctccagctgc tgcaggtact cctcatcgtg tgcctaggac tcatgctagg ctgttcctgg      480

tctctgcagg gtctgtagct cctgcccgct ctgtgctccg cacagtctga ggcttcttga      540

agagctgctg tgactgactg ttccactaaa gacatctcat acacgtcgtg acttggaacg      600

tggcttcggc agcgccccct ctagatctca gtgacctgct tcagctgaac aaccggaacc      660

tcaatcttga catatatgtt attggtttgc aggaattgaa ctctgggatc ataagcctcc      720

tttccgatgc tgcctttaat gactcgtgga gcagtttcct catggatgtg ctttcccctc      780

tgagcttcat caaggtctcc catgtccgta tgcaggggat cctcttactg gtctttgcca      840

agtatcagca tttgccctat atccagattc tgtctactaa atccaccccc actggcctgt      900

ttgggtactg ggggaacaaa ggtggagtca acatctgcct gaagctttat ggctactatg      960

tcagcatcat caactgccac ctgcctcccc acatttccaa caattaccag cggctggagc     1020

actttgaccg gatcctggag atgcagaatt gtgaggggcg agacatccca aacatcctgg     1080

accacgacct cattatctgg tttggagaca tgaactttcg gatcgaggac tttgggttgc     1140

actttgttcg ggaatccatt aaaaatcggt gctacggtgg cctgtgggag aaggaccagc     1200

tcagcattgc caagaaacat gacccgctgc tccgggagtt ccaggagggc cgcctactct     1260

tcccgcccac ctacaagttt gataggaact ccaacgacta tgacaccagt gagaaaaaac     1320

gcaagcctgc atggaccgat cgcatcctgt ggaggctgaa gcggcagccc tgtgctggcc     1380

ccgacactcc cataccgccg gcgtcacact tctccttgtc tctgaggggc tacagcagcc     1440

acatgacgta cggcatcagc gaccacaagc ctgtctccgg cacgttcgac ttggagctga     1500

agccattggt gtctgctccg ctgatcgtcc tgatgcccga ggacctgtgg accgtggaaa     1560

atgacatgat ggtcagctac tcttcaacct cggacttccc cagcagcccg tgggactgga     1620

ttggactgta caaggtgggg ctgcgggacg ttaatgacta cgtgtcctat gcctgggtcg     1680

gggacagcaa ggtctcctgc agcgacaacc tgaaccaggt ttacatcgac atcagcaata     1740

tccctaccac tgaagatgag tttctcctct gttactacag caacagtctg cgttctgtgg     1800

tggggataag cagacccttc cagatcccgc ctggctcctt gagggaggac ccactgggtg     1860

aagcacagcc acagatctga gccaggatgg gagtgaatcc caggcggagg ccagagctgg     1920

cagccagctc tgcctttcca ctgccgggag tgctgggggc ccagcctggc cccctgaaga     1980

gacagccaag tgtcgtccac atactcctcc cagagtgagc tctaaccagg ctcatttgct     2040

ctctccacta ctcatctctg gaattagccg cttaaataca ggtttttgtt gctgagatgt     2100

gagtgaaacc agctagtgtg tcaacagtga agacctgggg acagttctgc gtctcatttc     2160

tggattccta ccccctcttc tagtcttgcc caagtagtcc tgccaggcac atgccccatt     2220

tggcacaggc ctgcattctt gtcgtgccgt cctgggcctc aggctgtctg ggaggggaga     2280

tgctcacatt tgtacaggct acatagactg gtgcaagcag tgctggattc caggagtctt     2340

ggcatctcat agcttgtccc cgtgaggagt gagcagaggg tctgggattt ctgctttcag     2400

caaaagcagt ctgactcagt gggcagaatg gaggggcccc tctagccagg ctcttacgcc     2460

atggttatga gcaggttgat gagggtcctt cggccagcac aaccttcctc cctactcacg     2520

gcatggagtc tgactgcatg gaagttccag atcctgacag agagaactgg gaaggatcca     2580

ggttcgcttc cgttggtagc ttgagtccca tgcctccacc ctgccatctg aggaaggggt     2640

gacaagtggt caaggagctg tggccacaga cttttccagg gtggtccttg gcaggtgagg     2700

tgcgtctgtg ccacccttgt caggagccat tgacgacggg ccccccctgg accccccggg     2760

acctcagagt gggggcaggc agaagggaga accagctcaa gacattttgg aggatctggc     2820

cctggggttc ttcagagaac accctctagg ggctttgggg acatggcctg tccccacatc     2880

cagcacttgc ctccgccatg gtcactcggc agcccttttc ccaggagaag acacctctgg     2940

gagcctgctc agtgcttgtc ctgccatcct gtgtcctggg actgagggtt actccagttg     3000

ctctgtgttg catactctcc cccgcaagcc tgtgtatgaa gaattgtccc ctggcttcca     3060

gcaggccatg gctggctgtt ttgtgactgt taca                                 3094


<210> 2627
<211> 718
<212> DNA
<213> Homo sapiens

<400> 2627
gaggaaagat actggggagt gggagccgcg gggttcagag cgatgattcc cccacaggag       60

gcatccgctc gacggcggga gattgaggac aagctgaagc aggaggagga gactctgtcc      120

ttcatccgag acagcctgga gaagagcgac cagctcacta agaacatggt gtctatctta      180

tcatcctttg agagccgcct tatgaagctg gagaactcca tcatccctgt gcacaagcag      240

acggagaatc tgcagcggct gcaggagaat gttgagaaga cgctgtcctg cctggaccat      300

gtcatcagct actaccatgt ggccagtgac actgagaaga tcatcagaga gggccccaca      360

ggtaggctgg aagagtacct gggaagcatg gccaagattc agaaggcagt ggagtatttc      420

caggacaaca gcccagacag cccggaactc aacaaagtgg taaggggtcc gcagaataac      480

gtgagaagct tggggatatc agtctctgcc ctggtctcat gagggacatg gagccagctt      540

gaggatgtat gcagtagaat acacagaagg atatagcaca gtacatccta taggcattag      600

gatctctgct tcaagaattg cacatttttt attattaaaa attctttatt ataaaacttg      660

ttaatgtatt ataaaaatta aattataaat tacatataaa atataaactt aacatttg        718


<210> 2628
<211> 243
<212> DNA
<213> Homo sapiens

<400> 2628
atggcttcag aagagctaca gaaagatcta gaagaggtaa aggtgttgct ggaaaaggct       60

actaggaaaa gagtacgtga tgcccttaca gctgaaaaat ccaagattga gacagaaatc      120

aagaacaaga tgcaacagaa atcacagaag aaagcagaac ttcttgataa tgaaaaacca      180

gctgctgtgg ttgctcccat tacaacgggc tatacggatg ggatcagtca gataagtttg      240

tga                                                                    243


<210> 2629
<211> 1133
<212> DNA
<213> Homo sapiens

<400> 2629
actcccagac tccttgcgga gctcgccgcc tgattctagg ctggtcacta ctccgagcct       60

gtgacgtttg cggcagccag gccgtcgacg atgcccagtg aaactctctg ggaaattgca      120

aaagctgaag tggaaaaaag gggaattaat ggaagtgaag gtgatggagc tgaaattgca      180

gaaaaatttg ttttcttcat tggcagtaaa aatgggggaa agactactat tattctaagg      240

tgtcttgaca gagatgaacc accaaaacca accttagctt tggaatatac atatggaaga      300

agagcaaaag ggcacaacac accaaaagat atcgctcact tttgggaact cggtggagga      360

acctctttat tggacttaat cagcataccc atcacaggtg acaccttacg gacgttttct      420

cttgttctcg ttctggatct ttcaaaacct aatgatctct ggcccaccat ggaaaatctc      480

ttgcaagcca caaaaagcca tgtagacaaa gtgataatga aactgggaaa gacaaatgct      540

aaagcagttt ctgaaatgag acagaagatc tggaataata tgccgaagga tcatcctgtg      600

agttgctgtt tgggattatt actggaatcc ttagtcccat ttatagttaa tgataacatc      660

acaaacaact tctttagatt tttatgcatg acttgaaatt catttgatgt agatgaacct      720

gttcactgga aaattacagc aatttattaa aacctcagta agagcaaaac aaggaagaag      780

attccttata tcttcttgtt agacatcttc tgtgattgtt atggcatatt acaccaatca      840

gagaaataga gttttaaagt agtggtttga tattgatttt ataatctctg taaaaatgaa      900

gataaaaagc cagattgtac aaaagtcacc tgacaaagac tagatgaagc tacaacttta      960

agcaaggggt agagttgtaa tagccttcac catcactctg tattttacat tcatttcgtt     1020

tctgtcactt attcagtatc tttttatcat ctgacagcta attaaattat aaagttgcta     1080

tgatggtaac acaagttctt caaatacaat aataaatatc atcatctgga aaa            1133


<210> 2630
<211> 2282
<212> DNA
<213> Homo sapiens

<400> 2630
aggtaaggtg gccgtaaggg cgcggtgggc tccacgacgg ggtgatctct gggaccactg       60

gatgtgggtc ccggcgcgag gcagcttccg ggtcgcggcc agctccggcc gacctcccgc      120

ccggccctca ggctgctccc acagttcccg gtccctagac aaccctggct ctgcccgccc      180

acttcgcgtg ttcgattggc ttgtccttcc cctttctaag accggagact aaggcctgtt      240

agacgtttct gtgtttctgc acctgagttt ttttggtcta ggctccgtct ggtcaaatct      300

cgctgattcc cacagcctct tgtcctttgc tccacctcat tgcacccgta atgttgtatt      360

gtcattgtct gtttactgtc ccttttctct aaggcgtgtg agttcctcaa aggcaggcac      420

agtgtcttat tcgcctctgt atccttagct ctctgcttgg catctagact ctaggatgag      480

cgttttgaat tcacgacttg gcggctgtcc ttgactgtgt ctctttcctt ctaggcggct      540

tatgacccct acgcttatcc cagcgactat gatatgcaca caggagatcc aaagcaggac      600

cttgcttatg aacgtcagta tgaacagcaa acctatcagg tgatccctga ggtgatcaaa      660

aacttcatcc agtatttcca caaaactgtc tcagatttga ttgaccagaa agtgtatgag      720

ctacaggcca gtcgtgtctc cagtgatgtc attgaccaga aggtgtatga gatccaggac      780

atctatgaga acagatgctg tcttcctgat tttatacaaa gaattatact acaggcacat      840

atatgccaaa gtcagtgggg gaccttcctt ggagcagagg tttgaatcct attacaacta      900

ctgcaatctc ttcaactaca ttcttaatgc cgatggtcct gctccccttg aactacccaa      960

ccagtggctc tgggatatta tcgatgagtt catctaccag tttcagtcat tcagtcagta     1020

ccgctgtaag actgccaaga agtcagagga ggagattgac tttcttcgtt ccaatcccaa     1080

aatctggaat gttcatagtg tcctcaatgt ccttcattcc ctggtagaca aatccaacat     1140

caaccgacag ttggaggtat acacaagcgg aggtgaccct gagagtgtgg ctggggagta     1200

tgggcggcac tccctctaca aaatgcttgg ttacttcagc ctggtcgggc ttctccgcct     1260

gcactccctg ttaggagatt actaccaggc catcaaggtg ctggagaaca tcgaactgaa     1320

caagaagagt atgtattccc gtgtgccaga gtgccaggtc accacatact attatgttgg     1380

gtttgcatat ttgatgatgc gtcgttacca ggatgccatc cgggtcttcg ccaacatcct     1440

cctctacatc cagaggacca agagcatgtt ccagaggacc acgtacaagt atgagatgat     1500

taacaagcag aatgagcaga tgcatgcgct gctggccatt gccctcacga tgtaccccat     1560

gcgtattgat gagagcattc acctccagct gcgggagaaa tatggggaca agatgttgcg     1620

catgcagaaa ggtgacccac aagtctatga agaacttttc agttactcct gccccaagtt     1680

cctgtcgcct gtagtgccca actatgataa tgtgcacccc aactaccaca aagagccctt     1740

cctgcagcag ctgaaggtgt tttctgatga agtacagcag caggcccagc tttcaaccat     1800

ccgcagcttc ctgaagctct acaccaccat gcctgtggcc aagctggctg gcttcctgga     1860

cctcacagag caggagttcc ggatccagct tcttgtcttc aaacacaaga tgaagaacct     1920

cgtgtggacc agcggtatct cagccctgga tggtgaattt cagtcagcct cagaggttga     1980

cttctacatt gataaggaca tgatccacat cgcggacacc aaggtcgcca ggcgttatgg     2040

ggatttcttc atccgtcaga tccacaaatt tgaggagctt aatcgaaccc tgaagaagat     2100

gggacagaga ccttgatgat attcacacac attcaggaac ctgttttgat gtattatagg     2160

caggaagtgt ttttgctacc gtgaaacctt tacctagatc agccatcagc ctgtcaactc     2220

agttaacaag ttaaggaccg aagtgtttca agtggatctc agtaaaggat ctttggagcc     2280

ag                                                                    2282


<210> 2631
<211> 1913
<212> DNA
<213> Homo sapiens

<400> 2631
caagtctctg gacaaacctg aacagttcct ttatgaactg tcactaatcc ccaacttttc       60

agagcgagtc ttttgcatcc tgttccagtc cacattttca gaaagcattt gctcaattcg      120

tcgcaaactg gaattactac agaaattgtg tgagacatta aaaaatggcc caggggttat      180

gcaggttcta ggtttggttc ttgcctttgg caactacatg aatggaggaa ataagactcg      240

aggacaggca gatggctttg gattagacat tcttccaaaa ctgaaagatg tcaagagcag      300

tgacaatagc agaagccttt tgtcatatat tgtttcgtat tatctccgaa attttgatga      360

ggatgctgga agaacagtgc ctctttccac tgccagaacc ccaggacctt tttcaggcct      420

cacagatgaa gtttgaagat tttcaaaaag atctcagaaa actgaagaaa gacttgaaag      480

cctgtgaagt tgaagcaggg aaagtatacc aggtctcctc aaaagagcat atgcagcctt      540

tcaaggaaaa catggaacaa tttattattc aagccaaaat tgaccaagag gcagaggaaa      600

attcactgac agagactcat aaatgctttt tggagaccac ggcatatttc ttcatgaaac      660

caaaacttgg agagaaggag gtgtccccaa atgctttctt cagtatctgg catgaattca      720

gctctgactt taaagacttc tggaagaaag agaacaaact tcttctacaa gagagagtaa      780

aagaagccga agaggtgtgt agacagaaga aaggaaaatc actttataaa ataaaaccaa      840

gacatgactc tggaattaaa gcaaagataa gcatgaaaac ttgaacaatg aaaagcagaa      900

tgaaaatgag tcattgcaac gactttcaca aaattcagct gacctgagag tgggagggaa      960

actaccgtca ttctgctcat gtttcttctt gacctcttgc ataatctttt tgttttctag     1020

acagttcact aattgttgaa ttttactgta tattcatata aaaatgcaaa cgtactagac     1080

cagtggagaa tttgacacct tttctttttg taaaagttta tggtattata ccgatagacc     1140

aaaacagcat gtgtaagagg cagtatctgc actaattctc aacatgctaa acattaacta     1200

caattcactg ttgtgagaat attcctcgtc acagcaaaaa cactttcctt tctactgaca     1260

accagtcctc cacatcacag catttagaca tatgggtaaa atgttatttc tagtgaattg     1320

tttgtatcag tttcatgtct aagtataaat tttctatttt aaaatttaag aaccgtttat     1380

aatcagtgct ttcccaactc ttgggttgct ctccataact atgtatttgt gaaagaaaat     1440

ggtcattttt tttactgaag tcatataatg acttgggtca gctcgtaatg cattgtgatg     1500

gttttgtatg agctgggtgt ttttttccat tacttttaat gatcttcgtt gcaagttata     1560

gttgtggata aaggggagaa tttattgctc ttgcaaacca attatggaaa gcaacttaag     1620

aaaaccaatg ttctaaatca taattgtttg tatttatgta aagtatggtc tcttactttt     1680

tagtttgtag tttaagtgca aagaaacagt agtggttttt tttctattgt tttgtagtct     1740

tcctgtcccc ttcagtccct ccagtgtgta tattaccatt ctccaatgaa ataatagggc     1800

atttaacaaa gatcgctatg tgcaatactg tatttagtgt ttctatttca atttttctag     1860

gatgttaatt tatatgaaaa taaaatgaat aataaaagaa taaagatact tgc            1913


<210> 2632
<211> 1078
<212> DNA
<213> Homo sapiens

<400> 2632
gccaaatctt aaaggatccg ggagctaagc cagacccggg tggcggtggc agctgcgaaa       60

cccagggagc cgatgccacg tgacccaatg tggacttctt ttaaaccttt ctaatgccca      120

taacccagcc tcagacccat ggagcccacg agagactgcc cgctgttcgg gggcgccttt      180

tccgccatcc tccccatggg ggccattgac gtaagcgacc tccgaccggt cccggacaat      240

caagaagttt tctgccatcc cgtgacggac cagagcctga tagtggaact tctcgagctg      300

caggcccacg tacggggcga agcggctgcg cggtaccact ttgaggatgt tggtggcgtg      360

cagggggcta gggctgtcca tgtggagtct gttcagcctc tcagtttgga gaacctggcc      420

ctgaggggcc gctgtcaaga agcctgggtc ctctctggca agcagcagat agctaaggaa      480

aaccagcagg tagcaaagga cgtgacactt catcaggcct tgctgaggct gccccagtac      540

cagactgatc tcttgcttac cttcaatcag cccccgtaag gaggaaggaa cgggcgggta      600

tctcatgact gggttcccag gagaatcggg ctgggaggga cagaacaggg agactcactg      660

gtgggatcct ccaaggaagc aggagtgggc cagaggtttg gggtaactga tacccaggtc      720

ctctggggaa caggaattgg caatttccaa acctcaggcc tggatgatgt tctgtctcca      780

tctgttcccc caccccaagc cctgacaaca ggtcatctct tggccccgaa aatctgtcac      840

ctgcaccctg gagcctgggt gactttgaac agctggtgac cagtctgacc cttcacgatc      900

ctaacatctt tggtccccag taaaggcgct gaagcactgc atgatgttgc tgagaacttg      960

gggactcggt tctgtgaggg ggaaaagagg ttgaaaagag ggtttcctct tatttcttcc     1020

ctgtgcgtaa acataagaca atccctcttc agaataaact tgctttataa tcaatata       1078


<210> 2633
<211> 4047
<212> DNA
<213> Homo sapiens

<400> 2633
ccccggctct ctttctcctc tctgtcctgc tgtcgcctcc tctcctcact ccagcctcct       60

tccctggctt attctgccca ggaaagtttg gaacccccgc cccccctccc caatcaggtc      120

aacctgacta ggagtagggg gagatgtagg aaggcctgag agttcggggg gggggaagct      180

ggaagctggt ttcccagaaa atttcccccc atcttctcca tttagggtgg tgggaatttt      240

ttttaatcct gtttttgagg aggtggtagg tgtttagaaa aggatgtggg aatggaaggg      300

gtagatgagt caaccctctt tcaagattcc aagggtggtg tgttacctga tccttttcgt      360

gtgtggagtt cagggggtcg ggaggtttgg cctttattcc cacattcaaa gttggaacct      420

cccccaaatt aagaatggag ttttagtacc cacttgtggc aggaatcctg gggggaaggg      480

gtcctttttt cctttttctt ttcttttttc cctttttttt ccttttggca acccacaccc      540

ttccacacac gctcacccca aaattaaaca ccaagatcct ctaacttgtt tggattgact      600

gatgaagaca taaagctcta tgttttttga ggtggagtga gtggtttttc ttcattttta      660

aatggccaaa tgacagcttg acccagtttg ctttccaatc aaagggcatt tattttgaat      720

gtctctttgt ggcgcaagag ccaacgcaaa aatgatggcg gcttacaatg gcggtacatc      780

tgcagcagca gcaggtcacc accaccacca tcaccaccac cttccacacc tccctcctcc      840

tcacctgcac caccaccacc accctcaaca ccatcttcat ccggggtcgg ctgccgctgt      900

acaccctgta cagcagcaca cctcttcggc agctgcggca gccgcagcag cggctgcagc      960

tgcagccatg ttaaaccctg ggcaacaaca gccatatttc ccatcaccgg caccggggca     1020

ggctcctgga ccagctgcag cagccccagc tcaggtacag gctgccgcag ctgctacagt     1080

taaggcgcac catcatcagc actcgcatca tccacagcag cagctggata ttgagccgga     1140

tagacctatt ggatatggag cctttggtgt tgtctggtca gtaacagatc caagagatgg     1200

aaagagagta gcgctcaaaa agatgcccaa cgtcttccag aatctggtct cttgcaaaag     1260

ggtcttccgg gaattgaaga tgttgtgttt ttttaagcat gataatgtac tctctgccct     1320

tgacatactc caacctccac acattgacta ttttgaagaa atatatgttg tcacagaatt     1380

gatgcagagt gacctacata aaattatcgt ctctcctcaa ccactcagct cagatcatgt     1440

caaagttttt ctttatcaga ttttgcgagg tttgaaatat ctccattcag ctggcatttt     1500

acatcgagac attaagccag ggaatctcct tgtgaacagc aactgtgttc taaagatttg     1560

tgattttgga ttggccagag tggaagaatt agatgaatcc cgtcatatga ctcaggaagt     1620

tgttactcag tattatcggg ctccagaaat cctgatgggc agccgtcatt acagcaatgc     1680

tattgacatc tggtctgtgg gatgtatctt tgcagaacta ctaggacgaa gaatattgtt     1740

tcaggcacag agtcccattc agcagttgga tttgatcacg gatctgttgg gcacaccatc     1800

actggaagca atgaggacag cttgtgaagg cgctaaggca catatactca ggggtcctca     1860

taaacagcca tctcttcctg tactctatac cctgtctagc caggctacac atgaagctgt     1920

tcatctcctt tgcaggatgt tggtctttga tccatccaaa agaatatccg ctaaggatgc     1980

cttagcccac ccctacctag atgaagggcg actacgatat cacacatgta tgtgtaaatg     2040

ttgcttttcc acctccactg gaagagttta taccagtgac tttgagcctg tcaccaatcc     2100

caaatttgat gacactttcg agaagaacct cagttctgtc cgacaggtta aagaaattat     2160

tcatcagttc attttggaac agcagaaagg aaacagagtg cctctctgca tcaaccctca     2220

gtctgctgct tttaagagct ttattagttc cactgttgct cagccatctg agatgccccc     2280

atctcctctg gtgtgggagt gatggtggaa gataatgtac tactgaagat gtaatgtagc     2340

tttccactgg agtctgggat ttgcaattct ggaggttaat catgcttgta ctgtaatttt     2400

actaatgaag ttttaaatta acaaccacta cttgtatgat atgaataata tttagaaatg     2460

ttactagact tttaatcttg taaagtggtt gtgcttttag aagaaaaata ttttacccag     2520

agttgcacat gttttatgaa tttagtgcag ctgttatggc tcacctcaga acaaaagaga     2580

attgaaccaa atttgggagt ttggggtttt atgttttgtt tttcttttct aaaatgaagt     2640

gagattgttc acacacacac acacacacac acacacacac aaacacaaag gacagtcata     2700

cattttgata tttgagccat tcctaaagat ttggggtttt ctaaaactaa agaatctagg     2760

aaccttgcct gcgaccaatc atggagccac gtgagctgat cgtggctgca cctgggggga     2820

gggtagggag gaggggcatg ccacctaatg atcaagccct ataattagct tctcattaga     2880

gccgtgatgg tgatgtgtgc tgtctaaaat ccaatgttgt gggtagagag aatgagtttg     2940

tgactaggag agactaaact tttgttttcc ttacccagta taaatatata tatatatatt     3000

taatctattt ttattagaag tttttctgct ctttcttaca taaaagaacc ccaagcatgc     3060

atctttcatg tgtgtaaata attcatttct gggctaattt caaaagaatc ccaatattgc     3120

tgtatagaaa gagaactagc ttgcacattt taggtctgtg aaattttgtg agacttttcc     3180

tgcactggac agtaaaaaaa taataaaaga caaaaacaaa tttaaaaaaa aatttaagcc     3240

acaaaaaaag gcacataggg aattatgtca aatgtgtttg tgtccttagg caaagctgtg     3300

ggagtcttga aatgtcacag tagtaaataa cttattactt tttgacaagt tctttttttc     3360

tgttggaaca ctgaattctt ctgtgcatat gtacatatga atacaaatcg aaggcctcta     3420

cctcctggag ttatacaact tggcttgttt acctccacat gctgatgatg actatttttt     3480

ttttttgagt tcagtgtgga gacttgaaac ttgaatgtcc cttccaactt ttatattaaa     3540

aataaaaaga caagaaaatt gaagatcatt tttcacctgt acaaggaata ctaatggatc     3600

gtcttaaaat tggtctagga aaaaaccttg gtgtgtgtta tggacaatta actgttaaag     3660

ttattgtaag ttatctgtat ttagcagagt attttcaact tgagtgatct gagctgaatt     3720

tgaagactat taataagtta tgtttggaag ttttaacttc aatgaagtaa ttatttgctg     3780

tgaaagaaac aaacattgaa ttactaaaca aagatggtgc aatatctttg tttttttttt     3840

atgaggctcc tgagaatcaa cccaactgaa gcatttcaat tcacttgaat gagaaacgtg     3900

tttagtatca aaagagccca agaagacact ggtgtgaaag gtacaatctc agaggttggt     3960

caattaccgt ggcacacttt ctggtcactt tgtacaatgt agatttgaag tacagtggtg     4020

aaaacattaa atgtgacatt tgaaaaa                                         4047


<210> 2634
<211> 3563
<212> DNA
<213> Homo sapiens

<400> 2634
ggttccgctg aggcgtggta ggaagtggct gccgtcaatc actcggggag actccaaaca       60

gtgagcctag agctggagac tagcgttaac cggcggggcg gccggtttta tgaatgaagc      120

tatggctaca gattccccaa gaagacccag tcgttgtact ggtggagttg tggttcgccc      180

ccaggctgtc acagagcagt cctacatgga aagtgttgtg acttttctgc aggatgttgt      240

gccacaggct tacagtggaa cacctctaac agaagaaaag gagaaaatag tctgggtcag      300

atttgaaaat gcagatttaa atgatacatc aagaaatctg gaatttcatg aaatacatag      360

tactgggaat gaaccgcctt tgttgattat gattggctac agtgatggaa tgcaggtctg      420

gagcatccct atcagtggtg aagcacaaga gctcttctct gttcgacatg gcccaattcg      480

agcggctaga atcttgcctg ctccacagtt tggtgctcaa aaatgtgata actttgctga      540

aaaaagaccc ctccttggtg tttgtaagag cattggatct tctggcacaa gcccaccgta      600

ctgttgtgtg gatctgtatt cacttcgtac tggggagatg gtcaagtcca ttcaatttaa      660

gacacctatt tatgatctcc attgcaataa acggatcctt gtcgtagtct tgcaggagaa      720

aattgctgcc tttgatagct gtactttcac gaagaaattc tttgttacaa gctgctatcc      780

atgtccaggg ccaaacatga atcctattgc tcttgggagc cgctggcttg cttatgcaga      840

aaacaagttg attcgatgtc atcagtcccg tggtggagcc tgtggagaca acattcagtc      900

ttatactgcc acagtcatta gtgctgctaa aacattgaaa agtggcctga caatggtagg      960

gaaagtggtg actcagctga caggcacact gccttcaggt gtgacagaag atgatgttgc     1020

catccacagt aattcacggc ggagtccttt ggtcccaggc atcatcacag ttattgacac     1080

cgaaaccgtt ggagagggcc aggtgcttgt gagtgaggat tctgacagtg atggcattgt     1140

ggcccacttc cctgcccatg agaagccagt gtgctgcatg gcttttaata caagtggaat     1200

gcttctagtc acaacagaca cccttggcca tgactttcat gtcttccaaa ttctgactca     1260

tccttggtcc tcatcacaat gtgctgtcca ccatctgtat actcttcaca ggggagaaac     1320

tgaagccaaa gtacaggaca tctgcttcag ccatgactgt cgctgggttg tggtcagtac     1380

tctccggggt acttcccacg ttttccccat caacccttat ggtggccagc cttgtgttcg     1440

tacacatatg tcaccacgag tagtgaatcg catgagccgt ttccagaaaa gtgctggact     1500

ggaagagatt gaacaagaac tgacgtctaa gcaaggaggt cgctgtagcc ctgttccagg     1560

tctatcaagc agcccttctg ggtcaccctt gcatgggaaa ctgaacagcc aagactccta     1620

taacaatttt accaacaaca accctggcaa ccctcggctc tctcctcttc ccagcttgat     1680

ggtagtgatg cctcttgcac aaatcaagca gccaatgaca ttggggacca tcaccaaacg     1740

aaccggcaaa gttaaacctc ctccacaaat ttcacccagc aaatcgatgg gcggagaatt     1800

ttgtgtggct gctatcttcg gaacatccag gtcatggttt gcaaataatg caggtctgaa     1860

aagagaaaaa gatcagtcca aacaagttgt agttgagtcc ctgtacatta tcagttgcta     1920

tggcacctta gtggaacaca tgatggagcc gcgacccctc agcactgcac ccaagattag     1980

tgacgacaca ccactggaaa tgatgacatc gcctcgagcc agctggactc tggttagaac     2040

ccctcaatgg aatgaattgc agccaccgtt taatgcaaac caccctctgc tcctcgctgc     2100

agatgcagta cagtattatc agttcctgct tgctggcctg gttccccctg gaagtcctgg     2160

gcccattact cgacatgggt cttacgacag tttagcttct gaccatagtg gacaggaaga     2220

tgaagaatgg ctttcccagg ttgaaattgt aacacacact ggaccccata gacgtctgtg     2280

gatgggtcca cagttccagt tcaaaaccat ccatccctca ggccaaacca cagttatctc     2340

atccagttca tctgtgttgc agtctcatgg tccgagtgac acgccacagc ctcttttgga     2400

ttttgataca gatgatcttg atctcaacag tctcaggatc cagccagtcc gctctgaccc     2460

cgtcagcatg ccagggtcat cccgtccagt ctctgatcga aggggagttt ccacagtgat     2520

tgatgctgcc tcaggtacct ttgacaggag cgtgaccctg ctggaggtgt gcgggagctg     2580

gcctgagggc ttcgggctgc ggcacatgtc ctccatggag cacacggagg agggcctccg     2640

ggagcgactt gccgacgcca tggccgagtc acctagccgg gacgtcgtgg gatccggaac     2700

agaacttcag cgagagggaa gcatcgagac tctgagtaac agctcaggct ccaccagcgg     2760

cagcatacca agaaactttg atggctaccg atctccgctg cccaccaatg agagccagcc     2820

cctcagcctc ttcccgactg gcttcccgta ggtaccagca acctgcttct gactggccag     2880

ccccctcccc tgctggagga ggggagaagc cccgctctgg tcctaccctt cagtctctgc     2940

tcttccttca tcaaccacct tccccaagct tagtgacagc agccgcccat cctacctgga     3000

tggagaagag acccttctcc aagcacctca gcgcacttgc cctctgccac acctgtcggt     3060

ggaggctgtg gccaggagag actgtagaag ctcggtccct gtgtatgttt gcatatgaca     3120

tcctgcattg gatccgcttt tgtatttttt aaccataccc acggtggggc gggtgggggg     3180

agcctggaac agtgaccaga tctgggggcc tgagtgggga cagagttgat cgtccacctg     3240

gccattttga ccctgagtgg acagtcacag cctcagctca tgtctggctg tgacacacac     3300

tgcccccagc ttcccttggt cagccccact ccagcacggg gtgaacggag gcccagagta     3360

ctagggaagg aggaagggag gacatgcctc ttcttcctcc tttctttccc catctgttca     3420

tgggaagagt ttgtctttct tatctttaag cccctttacc ctggtcctgt actgatcagt     3480

gaaggaaacc gtggttactg aggccctgtt gaaaagtgca cgtcttgtcc aataaatcac     3540

gctgcagttg gtgtccatcc ctg                                             3563


<210> 2635
<211> 2705
<212> DNA
<213> Homo sapiens

<400> 2635
gtagggtggg ggtgctggcg gcggctgctt tggcggcggt tggtggccgt gcgggcgggg       60

agggaggggg aggagagaag aggaggtgga gaaggcttgg gctcgcgccg ctgaagtcgg      120

cttacccgct ggccgcctcc tgacaagcgg gagggatccg cggtggaccc agggaagcgg      180

aggagcctgg cggccacccc ctcttcctca cttccctgta ctctcatcgc tctcggcctc      240

cgacacgaaa aggaagcaaa tgagctgatg gaagatctgt ttgaaactgt gagtaatgat      300

cctcaagtga gaacatggga ttttccaaga tgagatggga ttctccaaca tggaagatga      360

tggcccagaa gaggaggagc gtgtggctga gcctcaagct aactttaaca cccctcaagc      420

tctacggttt gaggaactac tggccaacct actaaatgaa caacatcaga tagcgaagga      480

actatttgaa cagctgaaga tgaagaaacc ttcagccaaa cagcagaagg aggtagagaa      540

ggttaaaccc cagtgtaagg aagttcatca gaccctgatt ctggacccag cacaaaggaa      600

gagactccag cagcagatgc agcagcatgt tcagctcttg acacaaatcc accttcttgc      660

cacctgcaac cccaatctca atccggaggc cagtagcacc aggatatgtc ttaaagagct      720

gggaaccttt gctcaaagct ccatcgccct tcaccatcag tacaacccca agtttcagac      780

cctgttccaa ccctgtaact tgatgggagc tatgcagctg attgaagact tcagcacaca      840

tgtcagcatt gactgcagcc ctcataaaac tgtcaagaag actgccaatg aatttccctg      900

tttgccaaag caagtggctt ggatcctggc cacaagcaag gttttcatgt atccagagtt      960

acttccagtg tgttccctga aggcaaagaa tccccaggat aagatcctct tcaccaaggc     1020

tgaggacaac aagtaccttc taacctgcaa gactgcccgc caactgacag tgagaatcaa     1080

gaacctcaac atgaacagag ctcctgacaa catcattaaa ttttataaga agaccaaaca     1140

gctgccagtc ctaggaaaat gctgtgaaga gatccagcca catcagtgga agccacctat     1200

agagagagaa gaacaccggc tcccattctg gttaaaggcc agtctgccat ccatccagga     1260

agaactgcgg cacatggctg atggtgctag agaggtagga aatatgactg gaaccactga     1320

gatcaactca gatcaaggcc tagaaaaaga caactcagag ttggggagtg aaactcggta     1380

cccactgcta ttgcctaagg gtgtagtcct gaaactgaag ccagttgccg accgtttccc     1440

caagaaggct tggagacaga agcgttcatc agtcctgaaa cccctcctta tccaacccag     1500

cccctctctc cagcccagct tcaaccctgg gaaaacacca gcccaatcaa ctcattcaga     1560

agcccctccg agcaaaatgg tgctccggat tcctcaccca atacagccag ccactgtttt     1620

acagacagtt ccaggtgtcc ctccactggg ggtcagtgga ggtgagagtt ttgagtctcc     1680

tgcagcactg cctgctatgc cccctgaggc caggacaagc ttccctctgt ctgagtccca     1740

gactttgctc tcttctgccc ctgtgcccaa ggtaatgatg ccctcccctg cctcttccat     1800

gtttcgaaag ccatatgtga gacggagacc ctcaaaaaga aggggagcca gggcctttcg     1860

ctgtatcaaa cctgcccctg ttatccaccc tgcatctgtt atcttcactg ttcctgctac     1920

cactgtgaag attgtgagcc ttggcggtgg ctgtaacatg atccagcctg tcaatgcggc     1980

tgtggcccag agtccccaga ctattcccat cgccaccctc ttggttaacc ctacttcctt     2040

cccctgtcca ttgaaccagc cccttgtggc ctcctctgtc tcacccttaa ttgtttctgg     2100

caattctgtg aatcttccta taccatccac ccctgaagat aaggcccaca tgaatgtgga     2160

cattgcttgt gctgtggctg atggggaaaa tgcctttcag ggcctagaac ccaaattaga     2220

gccccaggaa ctatctcctc tctctgctac tgttttcccc aaagtggaac atagcccagg     2280

gcctccacca gtcgataaac agtgccaaga aggattgtca gagaacagtg cctatcgctg     2340

gaccgttgtg aaaacagagg agggaaggca agctctggag ccgctccctc agggcatcca     2400

ggagtctcta aacaactctt cccctgggga tttagaggaa gttgtcaaga tggaacctga     2460

agatgctaca gaggaaatca gtggatttct ttgagctagg agaataagag tctggagact     2520

gggagccttc acttcggcct ccgattggtg gcgcataggg tgtaaccaat aggaaacccc     2580

taaagggtac ttaaacccca gattttgcaa ctggggctct tgagcagctt gctttagcct     2640

gctcccactc tgtggaatat acttttgctt caataaatct gtgcttttat tgcttcattg     2700

tttca                                                                 2705


<210> 2636
<211> 818
<212> DNA
<213> Homo sapiens

<400> 2636
tcagggcggt ttgaaagatc ggcgcgcacc gcaggagcaa cggttggtcc tgcggctgtg       60

atgtcggtgt tgaggcccct ggacaagctg cccggcctga acacggccac catcttgctg      120

gtgggcacgg aggatgctct tctgcagcag ctggcggact cgatgctcaa agaggactgc      180

gcctccgagc tgaaggtcca cttggcaaag tccctccctt tgccctccag tgtgaatcgg      240

ccccgaattg acctgatcgt gtttgtggtt aatcttcaca gcaaatacag tctccagaac      300

acagaggagt ccctgcgcca tgtggatgcc agcttcttct tggggaaggt gtgtttcctc      360

gccacaggtg gtggaaggct ttagggccac catggcgcag cgcctggtgc gcgtgctgca      420

gatctgtgct ggccacgtgc ccggtgtctc agctctgaac ctgctgtccc tgctgagaag      480

ctctgagggc ccctccctgg aggacctgtg agggtggctg gcccctgggc tgccccttct      540

catggcttcg tgctgactcc ataaacattc tctgttgagg atgtccagtc agggcttgac      600

aggcccaggc tcagcccgcc gtggctggga aggttccctg cagtgccagt gctgcagcag      660

ggagagctgg gcagaagcag cgagggggcc cagctggcga gactgtagcc ccctcccact      720

cccacactca ctcttgcaga gcctgtgtct ttaagcagct ggcgtgttac atctccattt      780

aaggtttcct ttgaacaaaa ggtctgtggc taaaaaaa                              818


<210> 2637
<211> 1792
<212> DNA
<213> Homo sapiens

<400> 2637
atttgcccag gagcaagctc ccctgcactt tccatgtttg tattgggcat ccctttgtgc       60

cctgcccttt ctttctcagg aggggatgat agccagactc aactttttgt ttcatctaaa      120

gatgtgatta aagagattga agactttgac agcttggagg ctctgcgtct ggaaggcaac      180

acagtgggcg tggaagcagc cagggtcatc gccaaggcct tagagaagaa gtcggagttg      240

aagcgctgcc actggagtga catgttcacg ggaaggctgc ggaccgagat cccaccagcc      300

ctgatctcac taggggaagg actcatcaca gctggggctc agctggtgga gctggactta      360

agcgacaacg cattcgggcc cgacggtgtg caaggcttcg aggccctgct caagagctca      420

gcctgcttca ccctgcagga actcaagctc aacaactgtg gcatgggcat tggcggcggc      480

aaggtcatcg ggaccctgga ggaggtccac atgccacaga atgggatcaa ccaccctggc      540

atcactgccc tggcccaggc tttcgctgtc aaccccctgc tgcgggtcat caacctgaat      600

gacaacacct tcactgagaa gggcgccgtg gccatggccg agaccttgaa gaccttgcgg      660

caggtggagg tgattaattt tggggactgc ctggtgcgct ccaagggtgc agttgccatt      720

gcagatgcca tccgcggcgg cctgcccaag ctaaaggagc tgaacttgtc attctgtgaa      780

atcaagaggg atgctgccct ggctgttgct gaggccatgg cagacaaagc tgagctggag      840

aagctggacc tgaatggcaa caccctggga gaagaaggct gtgaacagct tcaggaggtg      900

ctggagggct tcaacatggc caaggtgctg gcgtccctca gtgatgacga ggacgaggag      960

gaggaggagg aaggagaaga ggaagaagag gaagcagaag aagaggagga ggaagatgag     1020

gaagaggagg aagaagagga ggaggaggag gaagaagagc ctcagcagcg agggcaggga     1080

gagaagtcag ccacgccctc acggaagatt ctggacccta acactgggga gccagctccc     1140

gtgctgtcct ccccacctcc tgcagacgtc tccaccttcc tggcttttcc ctctccagag     1200

aagctgctgc gcctagggcc caagagctcc gtgctgatag cccagcagac tgacacgtct     1260

gaccccgaga aggtggtctc tgccttccta aaggtgtcat ctgtgttcaa ggacgaagct     1320

actgtgagga tggcagtgca ggatgcagta gatgccctga tgcagaaggc tttcaactcc     1380

tcgtccttca actccaacac cttcctcacc aggctgctcg tgcacatggg tctgctcaag     1440

agtgaagaca aggtcaaggc cattgccaac ctgtacggcc ccctgatggc gctgaaccac     1500

atggtgcagc aggactattt ccccaaggcc cttgcacccc tgctgctggc gttcgtgacc     1560

aagcccaaca gcgccctgga atcctgctcc ttcgcccgcc acagtctgct gcagacgctg     1620

tacaaggtct agactcaaag cctctcccat cccttggcct ggaccagtga gctggggagg     1680

gactcggatg aactgaggcg cagcctacgc cattgccttg gacaggactc tggccacagg     1740

cagggcgggt ctgtgtccca tgtgtcctgt cagtcccctg agtatgtgtg tg             1792


<210> 2638
<211> 2900
<212> DNA
<213> Homo sapiens

<400> 2638
gaactgggcc aagcgccccc ggaggcgcta agcttgcgcc ctgaggcggt ttccgttccc       60

ggacgtttgg actctgtcct ggagaagggg aaggaaaaag taagacgtag aagtacactg      120

agacttcgtc acacataaaa caagcacgac aaagaaagag ggcgcgaagg gactcctgga      180

agaaattgag tctacattta agatcaccct aaaagtagtg acggcctctt cattactcca      240

aaccccagat ttaagtcggt aggacgtctt cgcgttgact tgtggggaat gtagtttcga      300

tgctgccggc gcgttttgtt tgcgacagaa actacaaccc ccaggggcca ccgcgacgtt      360

gcctgtgggt gcccgcgaac caacggttag cggtggcagg ggctgactga gagcgtctgc      420

ttgtgcctgg tacctagtac aaacttaata aatgtgtgac gcaagaataa aggaatgaat      480

gaatggaaga atgatataat gccacagaac tttcaaagat gggactgtct agttgcaaaa      540

acaagctcag ggatcccact gattctactt tacgataatg gattctgaat taatgcatag      600

tatagtagga agctatcata aacctccaga aagagtattt gttccctcat tcacccagaa      660

tgaaccatct cagaattgcc atcctgcaaa cttagaagtt acctctccta agatacttca      720

tagcccaaat agccaagctc ttattttagc cttaaaaact cttcaggaaa aaattcatcg      780

tttagagctg gagagaacac aagctgaaga taacctgaac attctttcca gagaagcagc      840

acagtataag aaggccttag agaatgaaac aaatgagaga aatctggcac accaggagct      900

gataaagcag aaaaaagata taagtataca gttaagctca gcccagtctc gttgtactct      960

tctagagaag caactagaat atacaaagag aatggttctc aacgtagagc gagaaaagaa     1020

catgatccta gaacaacagg cccagcttca gagggaaaaa gaacaagatc agatgaagct     1080

gtatgcaaaa cttgaaaagc ttgatgtctt agaaaaagag tgtttcagac ttacaacaac     1140

tcagaaaact gctgaggaca agattaaaca tttagaagaa aaacttaagg aagaagaaca     1200

tcagcgtaag ctatttcaag acaaagcttc tgagcttcaa actggacttg aaatcagtaa     1260

aattataatg tcttcagttt caaatctaaa gcactccaag gaaaagaaga aatcttcaaa     1320

gaaaactaaa tgtataaaga gacgaccacc ttggcaaatt tgttcaaagt ttggagcact     1380

gccttttgtg gctgaaaaga tgaggcaaca tcgtgaccca catatccttc agaaaccttt     1440

taacgtgact gagactagat gtctccccaa gccttctaga acaacttcct ggtgtaaagc     1500

tattcctcct gactcagaaa agtccatttc catttgtgac aatttatctg aacttttgat     1560

ggcaatgcaa gatgagctgg accaaatgag catggagcac caagaactac tgaaacaaat     1620

gaaggaaact gaaagtcatt cagtctgtga cgacatagaa tgtgaactag agtgtttact     1680

caagaaaatg gaaattaaag gagaacaaat ctccaaactg aagaagcatc aagacagtgt     1740

ctgtaaactg cagcaaaaag ttcaaaactc aaagatgagt gaagcttcag gtattcagca     1800

agaagacagc taccctaaag gatcaaagaa cataaaaaat agccccagaa aatgtttgac     1860

tgacactaac ctttttcaga aaaacagcag ctttcatcca atacgagttc ataatcttca     1920

aatgaaattg agaagagatg atatcatgtg ggaacagtaa caaaacagca aaactgtcac     1980

cttaatgaac tttgtcagtg agaccttgaa ttgtctaaag tggttttaat ttaatataac     2040

tttgtgacat tttgaatcat gtttctagtt tctataaaac atgaagttgc agtatttaaa     2100

aattaatgcc taatgacctg gtgggttcca aataataaat taattgcttt tttatttttc     2160

ttattgattg aagcccgtaa cctcatcttg tcttagaaac attgttggct ttgcagatat     2220

cttaagctaa atttaagaaa ttgtactaga ttgacaatat tcaaaattga gttaaatcca     2280

agctacaagt accattcatt ccacttttca tttagtaggt ttggaacctt aaaaaccaat     2340

gttcaatgaa cagagttcag aaagatcatt tagctttcct ggtgccttct ttctattttg     2400

ttttagagct gtgaaatgtt tttctctttt ggaaaaggaa aaacttaata gttacacagt     2460

tttgtgaaga agcctttaat ccaagtttta tgagacagta ggaacctata gctacttaat     2520

ttttaggaga cagtaattca gttgcagaag ctttcctctg ctattcccat tctcttttac     2580

aaaactagtt ttttttaaaa aatcaatgat caattttatc ttactacttt ataacttttg     2640

ctgactttta ttctttgcat tgtatgtaat gtccatcagt ataaattgag actgtgaatt     2700

tctaggaccc acaaaagtgg tatttttttt ttgtacaaga aagtatagag gaagaggaag     2760

ctgggcatta aattacctca tccagcagaa attcacggta gtatggtata tttttatttt     2820

ttatatttta aaatcaataa tgtcaaatgt cattgtgtat gcatgcttta taataaattt     2880

acacttgatc atttttctgg                                                 2900


<210> 2639
<211> 1978
<212> DNA
<213> Homo sapiens

<400> 2639
acggaagcgg tgagactgtc tctcggctgc agccctggtg cgacccggcc cgttgccgta       60

gagatgggca gggctggatg gagtggggtg cggtgagctg agctgaccct gcttcgccac      120

ggggactgca gtgaccccgg cttgccggca gggcgggtaa caggttgagc cagggtgggg      180

ctgctcaggg gcgtggagcc gaggccagga tttctctgaa gacccggcac aggctattcc      240

tttctgcgac gagcccattg ctatggaaac caaagcgtta ggccagcggg gattgaggct      300

gcgggatcat gacgggtctc tctcccgaag aaccttgcct aaggcttccc caagcggcta      360

cttcctgagc gaacccgccc acccgcctga aggagagagg taaaaccctg ggggtcctga      420

cactaagcag gcgaagaagc ctattccaat gccagctccc ctaggaaacc tacccggccc      480

acccctagaa gtgatgcttc gctctcgtta actcttggac tttgttccat gtttataact      540

tagtatttca cgaacgcccc gcggtgtttg ttcatttttc ccacacataa tggaccataa      600

aggtcggctt ctttgcttta tgactcgttc tgaacaagtc cttttccgcg ctgtgtctca      660

ctttcctctt ttgtaaaatg gaaatattaa ctctagacgc cggtctgatt aggttgcttt      720

gaagatcgaa ccagatgagg gaagccaaat acttcatagg ctgtaaagtg gtgaagctga      780

actgctaccg agttgctatt tttttctcct cctccctctc aagctaaacg ttctttagat      840

cttttgtgat ttcttcaggt ggtctttgcg actccctagg ctccgacctg gaagaaatct      900

tttttacact tccctttcac agagccctgc attttaactt ccctatcaga agcgagaaaa      960

atagttatca ttttgagagg gcttactcta tgccaagccc tgagaaaact ctttacgtgg     1020

attatctcgt ttaatttcac aacatccttt taagttttcc atggacacag cctagcagaa     1080

agacgcagcc ttcgtgcttc gctgactgct gaccactgac ccaccgcctt gatgacagca     1140

ccctcgtgtg ccttcccagt tcagttccgg cagccctcag tcagcggcct ctcgcagata     1200

accaaaagcc tgtatatcag caatggtgtg gccgccaaca acaagctcat gctgtctagc     1260

aaccagatca ccatggtcat caatgtctca gtggaggtag tgaacacctt gtatgaggat     1320

atccagtaca tgcaggtacc tgtggctgac tcccctaact cacgtctctg tgacttcttt     1380

gaccctattg ctgaccatat ccacagcgtg gagatgaagc agggccgtac tttgctgcac     1440

tgtgctgctg gtgtgagccg ctcagctgcc ctgtgcctcg cctacctcat gaagtaccac     1500

gccatgtccc tgctggacgc ccacacgtgg accaagtcat gccggcccat catccgaccc     1560

aacagcggct tttgggagca gctcatccac tatgagttcc aattgtttgg caagaacact     1620

gtgcacatgg tcagttcccc agtgggaatg atccctgaca tctatgagaa ggaagtccgt     1680

ttgatgattc cactgtgagc catcccacga gcccctgcat tggagtcaga gcccctgccc     1740

ttgatggatc agctggcacc acccagattg ataaactggc tcgtctgatc ttgtggcccc     1800

cacccaggaa ctgactgggc actagaaaac agcttcaaca tcctgtgatt tcatccctga     1860

ccaatcagca ctcctgtctc actggcttcc cccaacccac caagttgtcc ttaaaactct     1920

gctccctgaa tggtcgggga gactgatttc agtaatagta aaactctggt ctcctgca       1978


<210> 2640
<211> 2109
<212> DNA
<213> Homo sapiens

<400> 2640
cagaaattag ataacatcct aaatccaaaa gaaaagcata ttttttataa aagtgagaag       60

attttagaac agaatatttc ttccaagtct gacgagaaaa aaattaaaaa tacagataaa      120

cattgcattt tacagaatgt cacagaatca gaagatagtg atgtcatctg tcctacacaa      180

tacacaactg agagattccc cgacaatagt ataaggttta agccaccctt ggaaggatct      240

gaggattctg aaacagaaca cactgtaaaa acaagaaata atgataatag tcgaaacact      300

gatgacaaaa gaaatggaat aatttcaaaa aagttaagtc ctgagaacac aaccctgaaa      360

tctattttga aaagaaaagg caccagtgat atcagtgatg aatctgatga cattgaaatt      420

tcttccaagt caagagtaag aaagagagct agttcattga ggtttaagag aataaaagaa      480

accaaaaaag aacttcacaa ttctcccaaa acaatgaaca aaacaaacca agtgtatgca      540

gcaaatgagg atcataactc tcagtttatt gatgattatt catcctcaga tgagagttta      600

tccgtcagcc acttcagttt ctctaaacag agccacagac caagaactat aagagacaga      660

actagttttt cttcaaaatt gcctagccat aataagaaaa atagcacttt tattccaaga      720

aaaccaatga aatgttcaaa tgagaaagtt gttaatcaag agcagtcgta tgaatcaatg      780

gataaatttt tagatggcgt tcaggaagtg gcttatattc actcaaacca gaatgtaatt      840

ggatcgagca aagctgaaaa tcacatgagc cgatgggcag cacatgacgt atttgagttg      900

aagcagtttt ctcagctgcc tgctaacata gctgtttgca gttctaagac atataaagaa      960

aaagtggatg cagatacatt gccacacaca aagaaaggcc agcaaccgag tgaaggcagc     1020

atttcacttc ctctttacat ttcaaatcct gtaaaccaga agaagaaaaa agtctaccat     1080

acaaaccaga ccaccttcat aattggagaa acaccaaaag gaatccgcag aaaacaattt     1140

gaagaaatgg cctcttattt taactcgtct tctgtaaacg aatttgctaa acatataacc     1200

aatgccacat cagaagaacg acagaaaatg ctaagagact tttatgcttc tcaatatcca     1260

gaggtaaaag aattttttgt ggattctgtg tcacaattca acaattcttc ctttgagaaa     1320

ggagagcagc gcacccggaa gaaatctgat aaaagagaat ctcttataaa accaaggctg     1380

tcagattctg aaaccttgtc atttaaagat tctaccaaca aaatttctca agtttgcagc     1440

ctaaaaacat ataaaagaaa atcagttaag tttcagaatc atatttccta tagagaagag     1500

gtgtttttta atgatgcaga aactaagaaa tcacctgtta gttctactca agagattgac     1560

agtgggaaaa acagccaggc atccgaagat actgtgacat cccgttctct gaacagtgag     1620

tctgaaacac gtgagagaag gttagaaaat accatgaaag accaacagga cctcacaaga     1680

acgggcattt caagaaaaga accccttctc aaattggaaa acaaaaagat agaaaatcca     1740

gtgctggaaa atacttctgt gataagctta cttggtgata cctctattct tgatgacctt     1800

tttaaaagtc atgggaacag tcccacacaa ctgccaaaga aagttctttc agggcccatg     1860

gaaaaagcaa aacagagacc aaaagatttc tgggacatct tgaatgagca gaatgatgag     1920

agtcttagta aactcacaga cttggcagta atagagactc tgtgtgaaaa agcacctcta     1980

gcagcaccct ttaaaaggag agaagagcca gcaacttctc tttggaaatc aaatgagaaa     2040

tttttatgga agaaatttag cccaagtgat acagatgaaa acgcaaccaa tacacagagt     2100

accacataa                                                             2109


<210> 2641
<211> 1395
<212> DNA
<213> Homo sapiens

<400> 2641
gagcagccgg tcctccagtg gctccgctcc ccgttctctg tgggctcaaa atgacagggc       60

atactcggtc cagcttacca cgttgtacag gaattgtctt gctgataaaa ttgcgtttct      120

cggagaggct cacaggacac ctgcatgccc aaggcactcc accgtatgtg atcaacctgg      180

atccagcagt acatgaagtt ccctttcctg ccaatattga tattcgtgat actgtaaagt      240

ataaagaagt aatgaaacaa tatggacttg gacccaatgg cggcatagtg acctcactca      300

atctctttgc taccagattt gatcaggtga tgaaatttat tgagaaggcc cagaacatgt      360

ccaaatatgt gttgattgac acacctggac agattgaggt attcacctgg tcagcttctg      420

ggacaattat cactgaagcc cttgcatcct catttccaac agttgtcatc tatgtaatgg      480

acacatcgag aagtaccaac ccagtgacct tcatgtccaa catgctctat gcctgcagca      540

tcttatacaa aaccaagctg cctttcattg tggtcatgaa taaaactgac atcattgacc      600

acagctttgc agtggaatgg atgcaggatt ttgaggcttt ccaagatgcc ttgaatcaag      660

agactacata cgtcagtaac ctgactcgtt caatgagcct ggtgttagat gagttttaca      720

gctcactcag ggtggtgggt gtctctgctg ttctgggtac tggattagat gaactctttg      780

tgcaagttac cagtgctgcc gaagaatatg aaagggagta tcgtcctgaa tatgaacgtc      840

tgaaaaaatc actggccaac gcagagagcc aacagcagag agaacaactg gaacgccttc      900

gaaaagatat gggttctgta gccttggatg cagggactgc caaagacagc ttatctcctg      960

tgctgcaccc ttctgatttg atcctgactc gaggaacctt ggatgaagag gatgaggaag     1020

cagacagcga tactgatgac attgaccaca gagttacaga ggaaagccat gaagagccag     1080

cattccagaa ttttatgcaa gaatcgatgg cacaatactg gaagagaaac aataaatagg     1140

agactttagc acacttcact tgtttctaga agtccagaat tttggacctc cacgtgaaag     1200

aactgttctt acctctgaac tgggggctcc cataagggat aattttcctc agagtagcaa     1260

agtttctctt attagagaaa tcttgtgact cagatgaagt cagggataga agacccttgg     1320

acctggcagg ttaatgctga ttattccttg gcctttccct tgtatttatg caaggaagga     1380

tatactgagc tgata                                                      1395


<210> 2642
<211> 3080
<212> DNA
<213> Homo sapiens

<400> 2642
agaggtcaga catgccagca gggttggaaa gaggcaggta cggaagctga gctgcagagt       60

tagccggcat ctgacagaaa aatgtttgtc tacagatttt gagcgttcga agttgacccc      120

tgactaagta tactttgctg ctccctcagc ctttgaaaaa atgtctgtca catatgatga      180

ttccgttgga gtagaagtgt ccagcgacag cttctgggag gtcgggaact acaagcggac      240

tgtgaagcgg atcgacgatg gccaccgcct gtgcagcgac ctcatgaact gcctgcatga      300

gcgggcgcgc atcgagaagg cgtatgcgca gcagctcact gagtgggccc ggcgctggag      360

gcagctcgtg gagaaagggc cccagtacgg gaccgtggag aaggcctgga tggccttcat      420

gtccgaggca gagagggtga gcgagctgca cctcgaggtg aaggcctcac tgatgaacga      480

tgacttcgag aagatcaaga actggcagaa ggaagccttt cacaagcaga tgatgggcgg      540

cttcaaggag accaaggaag ctgaggacgg ctttcggaag gcacagaagc cctgggccaa      600

gaagctgaaa gaggtagaag cagcaaagaa agcccaccat gcagcgtgca aagaggagaa      660

gctggctatc tcacgagaag ccaacagcaa ggcagaccca tccctcaacc ctgaacagct      720

caagaaattg caagacaaaa tagaaaagtg caagcaagat gttcttaaga ccaaagagaa      780

gtatgagaag tccctgaagg aactcgacca gggcacaccc cagtacatgg agaacatgga      840

gcaggtgttt gagcagtgcc agcagttcga ggagaaacgc cttcgcttct tccgggaggt      900

tctgctggag gttcagaagc acctagacct gtccaatgtg gctggctaca aagccattta      960

ccatgacctg gagcagagca tcagagcagc tgatgcagtg gaggacctga ggtggttccg     1020

agccaatcac gggccgggca tggccatgaa ctggccgcag tttgaggagt ggtccgcaga     1080

cctgaatcga accctcagcc ggagagagaa gaagaaggcc actgacggcg tcaccctgac     1140

gggcatcaac cagacaggcg accagtctct gccgagtaag cccagcagtg tgagcagcta     1200

cgagaagacc cagagctatc ccaccgactg gtcagacgat gagtctaaca accccttctc     1260

ctccacggat gccaatgggg actcgaatcc attcgacgac gacgccacct cggggacgga     1320

agtgcgagtc cgggccctgt atgactatga ggggcaggag catgatgagc tgagcttcaa     1380

ggctggggat gagctgacca agatggagga cgaggatgag cagggctggt gcaagggacg     1440

cttggacaac gggcaagttg gcctataccc ggcaaattat gtggaggcga tccagtgatg     1500

agtcggggac aggccagcgg ggggacggag gcggcgggcc caggagcctc agccagccac     1560

gtgggcatcc actccttttc ctgcaagaga tgatggttcc attgctcttg gcttcatggt     1620

gttcctggaa ggcagatgag ctggtcattt cgcctgggac tcggcacctt tccgagtgca     1680

gctggaggga tctgagcgca ggaagacgca gaacaacaga aatagccgcc cctccccgcc     1740

cactgtgcct gttggcctat catagatctc tatgttcttg actttgtctc tcctttccga     1800

gtcaatggtg ggttacactg atcttgttcc actgattact ctctctgacg agtccatcac     1860

ctgcaactta aatgaacaag cttacatccc attttgagtg aagattttga ggtttttaat     1920

ttaaaggctg tgtacagtta tactttttta tacacctgtt catttctact taaattatgg     1980

cacagattga tgcgcaccag tcttgaggaa acgatctccc tattccctta ccctgttact     2040

cagccacgcc gtgtgtaggc ttagcctcag gtggcagatg tttgaggaaa ggaattatgc     2100

caggaaggtg ggaccgggtt atggtcgggt ttctattggg aatgctcttt gtgcttttgg     2160

gcatctgaat ggaagcttta catagaacct taggtagaac tcccccaaat cgccatattt     2220

aaaaattatt ttcactctat tcttgcttaa aactgtactc ttttgcaaat taacaatttt     2280

atcactgatt cagagttaaa aagaagacta acttttcaag caaatgcatc tgtaaagatg     2340

ctttagatta gactgtcatg tctcagtgtc tatctgtata tattatttga tattcagaga     2400

atctaaagca ctcgtctact gttttaatga gatttaacag cttttaacag tgagtttcgt     2460

ttgtaaactg cttgaagtct gtggcattca ggcacacgtc tggctggccg gctgggtctc     2520

ctcccgggct cagtgggcct ggggcctctc tgacgtggtg cctgctggag ggaggctcgt     2580

cgtcaccagc tgactgctgg tccggcttct gaccggcctt tgtcctggct ccgtagcaga     2640

acactgtaaa agtgcccgcg tctttgcagt agttgcagat ttcagtcgtc gtgttacttg     2700

tgcacaaaca gaagctgggt cttacccgca gcacgagtgt ctcgggctgc ccggagtcgc     2760

ccgggagcag gtgctgcagc cagagttacg cgggggccac gcgggccggc gggggtgggg     2820

ggaacgtggg ggaacctgtg tttcacgtga ctcagcagtg cccgccgccg tcaccagcta     2880

tgcattcact ccgtttccag tgagcagatg tcttgcttgg aaagtggacc tgtgtctgtg     2940

tctgtcctga gaacttacca gcagaaatcc tcatttctgt gctacggatt taccaaaaat     3000

tgtcaagtct ttttcagttt aacagttcct ttacatgtgt agtatttgag gaaaaaaatc     3060

aataaacagt tgatctcgtg                                                 3080


<210> 2643
<211> 521
<212> DNA
<213> Homo sapiens

<400> 2643
agagcgatga gtgagaacgc cgcaccaggt ctgatctcag agcttctcct gcaaagagga       60

accacgaagg tggccacagg tctggttctg aacagagacc agaggctcgc ctgggcagag      120

aacagcattg acttcatcag cagggagctg tgtgcgcatt ccatcaggaa gctgcaggcc      180

catgtcctgt tgatcaaagc agtccacgga tattttgatt caagacagaa ttactctgag      240

aaggagtccc tgtcgttcat gatagacacg atgaaatcca ccctcaaaga gcagttccag      300

tttgtggaag tcccaggcaa tcactgtgtc cacatgagcg aaccccagca cgtggccagt      360

atcatcagct ccttcttaca gtgcacacac atgctcccag cccagctgta gctctgggcc      420

tggaactatg aagacctagt gctcccagac tcaacactgg gactctgagt tcctgagccc      480

cacaacaagg ccagggatgg tggggacagg cctcactagt c                          521


<210> 2644
<211> 517
<212> DNA
<213> Homo sapiens

<400> 2644
gtaagatggc ggcggcgttg gtggtggcag tggacggggc ggctgggcct ggaacagtcg       60

gagcagccgc tagcagaagg atgacccaag acgggaagcg ggctgctgag cctcgccgat      120

tcccgtgctt gtaactgccc cagccggaca ccccccctcc cttgacctac ccggctggct      180

acagcaaaca tcattcaaga tgtccagcaa agggagcagc acagatggca gaacagactt      240

agctaatgga agcctgtcta gcagtccaga ggagatgtct ggagctgaag aggggaggga      300

gacatcctca ggcattgaag tggaggcctc agacctgagt ttgagcttga ctggggatga      360

tggtggcccc aaccgcacca gcacagaaag tcgaggcaca gacacagaga gctcaggtga      420

agataaggac tctgacagca tggaggacac tggtcattac tccattaatg atgaaaatcg      480

agtccatgac cgctcagagg aagaggaaga ggaggaa                               517


<210> 2645
<211> 1407
<212> DNA
<213> Homo sapiens

<400> 2645
atgcacacat acgcgcgcgc acatgcacat aggcacacag agatacgcgc acacacacac       60

acaaacgcac tcagatttcc cggaccctgg ttttcctcct gtgacccttt cggggccggg      120

ctctcaccct aaagaagcag ccccgccctg gggtggcccc accctctctt gggacctgtc      180

ataagtcgga ccccgggcgc ccggctgcgc agtcccagcc gccttcccca ggcagtggaa      240

ccttcgggct cctgagcttc aggatggttc gtactaagac atggaccctg aagaagcact      300

ttgttggcta tcctactaat agtgactttg agttgaagac agctgagctc ccacccttaa      360

aaaatggaga ggtcctgctt gaagctttgt tcctcaccgt ggatccctac atgagagtgg      420

cagccaaaag attgaaggaa ggtgatacaa tgatggggca gcaagtggcc aaagttgtgg      480

aaagtaaaaa tgtagcccta ccaaaaggaa ctattgtact ggcttctcca ggctggacaa      540

cgcactccat ttctgatggg aaagatctgg aaaagctgct gacagagtgg ccagacacaa      600

taccactgtc tttggctctg gggacagttg gcatgccagg cctgactgcc tactttggcc      660

tacttgaaat ctgtggtgtg aagggtggag aaacagtgat ggttaatgca gcagctggag      720

ctgtgggctc agtcgtgggg cagattgcaa agctcaaggg ctgcaaagtt gttggagcag      780

tagggtctga tgaaaaggtt gcctaccttc aaaagcttgg atttgatgtc gtctttaact      840

acaagacggt agagtctttg gaagaaacct tgaagaaagc gtctcctgat ggttatgatt      900

gttattttga taatgtaggt ggagagtttt caaacactgt tatcggccag atgaagaaat      960

ttggaaggat tgccatatgt ggagccatct ctacatataa cagaaccggc ccacttcccc     1020

caggcccacc cccagagatt gttatctatc aggagcttcg catggaagct tttgtcgtct     1080

accgctggca aggagatgcc cgccaaaaag ctctgaagga cttgctgaaa tgggtcttag     1140

agggtaaaat ccagtacaag gaatatatca ttgaaggatt tgaaaacatg ccagctgcat     1200

ttatgggaat gctgaaagga gataatttgg ggaagacaat agtgaaagca tgaaaaagag     1260

gacacatgga atctggaggc catttagatg attagttaat ttgtttttca ccatttagca     1320

aaaatgtata ctaccttaaa tgtcttaaga aatagtactc ataatgagtt tgagctactt     1380

aataaaatac atttaagtgg tatgtaa                                         1407


<210> 2646
<211> 2315
<212> DNA
<213> Homo sapiens

<400> 2646
gctgctgctc cagatgaggt gatggcaacg gccaacttcg gcaagatcca gatcgggatt       60

tacgtggaga tcaagcgcag cgatggccga atacatcaag caatggtaac atctttaaat      120

gaagataatg aaagtgtaac tgttgaatgg atagaaaatg gagatacaaa aggcaaagag      180

attgacctgg agagcatctt ttcacttaac cctgaccttg ttcctgatga agaaattgaa      240

cccagtccag aaacacctcc acctccagca tcctcagcca aagtaaacaa aattgtaaag      300

aatcgacgga ctgtagcttc tattaagaat gaccctcctt caagagataa tagagtggtt      360

ggttcagcac gtgcacggcc cagtcaattt cctgaacagt cttcctctgc acaacagaat      420

ggtagtgttt cagatatatc tccagttcaa gctgcaaaaa aggaatttgg acccccttca      480

cgtagaaaat ctaattgtgt gaaagaagta gaaaaactgc aagaaaaacg agagaaaagg      540

agattgcaac agcaagaact tagagaaaaa agagcccagg acgttgatgc tacaaaccca      600

aattatgaaa ttatgtgtat gatcagagac tttagaggaa gtttggatta tagaccatta      660

acaacagcag atcctattga tgaacatagg atatgtgtgt gtgtaagaaa acgaccactc      720

aataaaaaag aaactcaaat gaaagatctt gatgtaatca caattcctag taaagatgtt      780

gtgatggtac atgaaccaaa acaaaaagta gatttaacaa ggtacctaga aaaccaaaca      840

tttcgttttg attatgcctt tgatgactca gctcctaatg aaatggttta caggtttact      900

gctagaccac tagtggaaac tatatttgaa aggggaatgg ctacatgctt tgcttatggg      960

cagactggaa gtggaaaaac tcatactatg ggtggtgact tttcaggaaa gaaccaagat     1020

tgttctaaag gaatttatgc attagcagct cgagatgtct ttttaatgct aaagaagcca     1080

aactataaga agctagaact tcaagtatat gcaaccttct ttgaaattta tagtggaaag     1140

gtgtttgact tgctaaacag gaaaacaaaa ttaagagttc tagaagatgg aaaacagcag     1200

gttcaagtgg tgggattaca ggaacgggag gtcaaatgtg ttgaagatgt actgaaactc     1260

attgacatag gcaacagttg cagaacatcc ggtcaaacat ctgcaaatgc acattcatct     1320

cggagccatg cagtgtttca gattattctt agaaggaaag gaaaactaca tggcaaattt     1380

tctctcattg atttggctgg aaatgaaaga ggagctgata cttccagtgc ggacaggcaa     1440

actaggcttg aaggtgctga aattaataaa agccttttag cactcaagga gtgcatcaga     1500

gccttaggta gaaataaacc tcatactcct ttccgtgcaa gtaaactcac tcaggtgtta     1560

agagattctt tcataggtga aaactctcgt acctgcatga ttgccacaat ctctccagga     1620

atggcatcct gtgaaaatac tcttaataca ttaagatatg caaatagagt aaaggagttt     1680

ggaattagtc catcagacat tcccttctca cagggtagtg gcagtcgccc tgatctctct     1740

ccttcttatg aatatgacga cttttctcct tcagttacca gggtcaaaga attgactgta     1800

gatccaactg ctgctggtga tgttcgtcca ataatgcacc atccaccaaa ccagattgat     1860

gacttagaga cacagtgggg tgtggggagt tcccctcaga gagatgatct aaaacttctt     1920

tgtgaacaaa atgaagaaga agtctctcca cagttgttta ctttccacga agctgtttca     1980

caaatggtag aaatggaaga acaagttgta gaagatcaca gggcagtgtt ccaggaatct     2040

attcggtggt tagaagatga aaaggccctc ttagagatga ctgaagaagt agattatgat     2100

gtcgattcat atgctacaca acttgaagct attcttgagc aaaaaataga cattttaact     2160

gaactgcggg ataaagtgaa atctttccgt gcagctctac aagaggagga acaagccagc     2220

aagcaaatca acccgaagag accccgtgcc ctttaaaccg gcatttgctg ctaaaggata     2280

cccagaaccc tcactactgt aacatacaac ggttc                                2315


<210> 2647
<211> 2090
<212> DNA
<213> Homo sapiens

<400> 2647
actacccaga ctgcctctgc ttcagccatc gaggactcgg gcggaactaa gctacaaatc       60

cttcttcaaa ccacaccaaa aacctattgc aaacgtaaat gctgccccat tggaaagaaa      120

ggaaggctgg gaactaagaa gctattggtt ggtgatccct ggaccaatcg gaggagccgt      180

gatttggcgg gagtcttgac cgccgccggg ctcttggtac ctcagcgcga gcgccaggcg      240

tccggccgcc gtggctatgt tcgtgtccga tttccgcaaa gagttctacg aggtggtcca      300

gagccagagg gtccttctct tcgtggcctc ggacgtggat gctctgtgtg cgtgcaagat      360

ccttcaggcc ttgttccagt gtgaccacgt gcaatatacg ctggttccag tttctgggtg      420

gcaagaactt gaaactgcat ttcttgagca taaagaacag tttcattatt ttattctcat      480

aaactgtgga gctaatgtag acctattgga tattcttcaa cctgatgaag acactatatt      540

ctttgtgtgt gacacccata ggccagtcaa tgtcgtcaat gtatacaacg atacccagat      600

caaattactc attaaacaag atgatgacct tgaagttccc gcctatgaag acatcttcag      660

ggatgaagag gaggatgaag agcattcagg aaatgacagt gatgggtcag agccttctga      720

gaagcgcaca cggttagaag aggagatagt ggagcaaacc atgcggagga ggcagcggcg      780

agagtgggag gcccggagaa gagacatcct ctttgactac gagcagtatg aatatcatgg      840

gacatcgtca gccatggtga tgtttgagct ggcttggatg ctgtccaagg acctgaatga      900

catgctgtgg tgggccatcg ttggactaac agaccagtgg gtgcaagaca agatcactca      960

aatgaaatac gtgactgatg ttggtgtcct gcagcgccac gtttcccgcc acaaccaccg     1020

gaacgaggat gaggagaaca cactctccgt ggactgcaca cggatctcct ttgagtatga     1080

cctccgcctg gtgctctacc agcactggtc cctccatgac agcctgtgca acaccagcta     1140

taccgcagcc aggttcaagc tgtggtctgt gcatggacag aagcggctcc aggagttcct     1200

tgcagacatg ggtcttcccc tgaagcaggt gaagcagaag ttccaggcca tggacatctc     1260

cttgaaggag aatttgcggg aaatgattga agagtctgca aataaatttg ggatgaagga     1320

catgcgcgtg cagactttca gcattcattt tgggttcaag cacaagtttc tggccagcga     1380

cgtggtcttt gccaccatgt ctttgatgga gagccccgag aaggatggct cagggacaga     1440

tcacttcatc caggctctgg acagcctctc caggagtaac ctggacaagc tgtaccatgg     1500

cctggaactc gccaagaagc agctgcgagc cacccagcag accattgcca gctgcctttg     1560

caccaacctc gtcatctccc aggggccttt cctgtactgc tctctcatgg agggcactcc     1620

agatgtcatg ctgttctcta ggccggcatc cctaagcctg ctcagcaaac acctgctcaa     1680

gtcctttgtg tgttcgacaa agaaccggcg ctgcaaactg ctgcccctgg tgatggctgc     1740

ccccctgagc atggagcatg gcacagtgac cgtggtgggc atccccccag agaccgacag     1800

ctcggacagg aagaactttt ttgggagggc gtttgagaag gcagcggaaa gcaccagctc     1860

ccggatgctg cacaaccatt ttgacctctc agtaattgag ctgaaagctg aggatcggag     1920

caagtttctg gacgcactta tttccctcct gtcctaggaa tttgattctt ccagaatgac     1980

cttcttattt atgtaactgg ctttcattta gattgtaagt tatggacatg atttgagatg     2040

tagaagccat tttttattaa ataaaatgct tattttaggc tccgtcccca                2090


<210> 2648
<211> 902
<212> DNA
<213> Homo sapiens

<400> 2648
agaagaccgc cccactctcg tcgcactagg gaccccgaaa tccgaccgcc catgggaagc       60

cactcgccag agtcttacct gaggggattc cttaccccat caccatgtgc acctcagaaa      120

ctttccaagc gctggacacc ttcgaagcca gacatgatga catcgtgcta gcatcttatc      180

caaagtgcgg ttcaaactgg attctccaca ttgtcagtga attaatatat gctgtttcta      240

aaaaaaagta taaatatcca gaattcccag ttcttgaatg tggggattca gaaaaatatc      300

agagaatgaa aggctttcca tcaccaagga ttttggcaac tcacctccac tatgacaaat      360

tacctgggtc tatcttcgag aataaagcca agatattggt gatatttcga aaccctaaag      420

atacagcagt atcttttttg catttccaca acgatgtccc cgatattcca agctatggct      480

cttgggatga attcttcaga cagttcatga aaggacaagt ttcttgggga aggtattttg      540

attttgcaat caattggaac aaacatcttg atggcgacaa tgttaagttc atattatatg      600

aagacctgaa agagaatctg gctgctggaa taaaacagat tgctgagttc ttgggattct      660

ttctaactgg ggagcaaatt caaactatct cagtccagag caccttccaa gccatgcgtg      720

cgaagtctca ggacacacac ggtgctgtcg gcccattcct tttccgcaaa ggtgaagttg      780

gtgattggaa aaatttgttc agtgaaattc agaaccagga aatggatgaa aaattcaaag      840

agtgcttagc aggcacctcc ctcggagcaa agttgaagta tgaatcatat tgccagggtt      900

ga                                                                     902


<210> 2649
<211> 2808
<212> DNA
<213> Homo sapiens

<400> 2649
atgaatgaag ctatggctac agattcccca agaagaccca gtcgttgtac tggtggagtt       60

gtggttcgcc cccaggctgt cacagagcag tcctacatgg aaagtgttgt gacttttctg      120

caggatgttg tgccacaggc ttacagtgga acacctctaa cagaagaaaa ggagaaaata      180

gtctgggtca gatttgaaaa tgcagattta aatgatacat caagaaatct ggaatttcat      240

gaaatacata gtactgggaa tgaaccgcct ttgttgatta tgattggcta cagtgatgga      300

atgcaggtct ggagcatccc tatcagtggt gaagcacaag agctcttctc tgttcgacat      360

ggcccaattc gagcggctag aatcttgcct gctccacagt ttggtgctca aaaatgtgat      420

aactttgctg aaaaaagacc cctccttggt gtttgtaaga gcattggatc ttctggcaca      480

agcccaccgt actgttgtgt ggatctgtat tcacttcgta ctggggagat ggtcaagtcc      540

attcaattta agacacctat ttatgatctc cattgcaata aacggatcct tgtcgtagtc      600

ttgcaggaga aaattgctgc ctttgatagc tgtactttca cgaagaaatt ctttgttaca      660

agctgctatc catgtccagg gccaaacatg aatcctattg ctcttgggag ccgctggctt      720

gcttatgcag aaaacaagtt gattcgatgt catcagtccc gtggtggagc ctgtggagac      780

aacattcagt cttatactgc cacagtcatt agtgctgcta aaacattgaa aagtggcctg      840

acaatggtag ggaaagtggt gactcagctg acaggcacac tgccttcagg tgtgacagaa      900

gatgatgttg ccatccacag taattcacgg cggagtcctt tggtcccagg catcatcaca      960

gttattgaca ccgaaaccgt tggagagggc caggtgcttg tgagtgagga ttctgacagt     1020

gatggcattg tggcccactt ccctgcccat gagaagccag tgtgctgcat ggcttttaat     1080

acaagtggaa tgcttctagt cacaacagac acccttggcc atgactttca tgtcttccaa     1140

attctgactc atccttggtc ctcatcacaa tgtgctgtcc accatctgta tactcttcac     1200

aggggagaaa ctgaagccaa agtacaggac atctgcttca gccatgactg tcgctgggtt     1260

gtggtcagta ctctccgggg tacttcccac gttttcccca tcaaccctta tggtggccag     1320

ccttgtgttc gtacacatat gtcaccacga gtagtgaatc gcatgagccg tttccagaaa     1380

agtgctggac tggaagagat tgaacaagaa ctgacgtcta agcaaggagg tcgctgtagc     1440

cctgttccag gtctatcaag cagcccttct gggtcaccct tgcatgggaa actgaacagc     1500

caagactcct ataacaattt taccaacaac aaccctggca accctcggct ctctcctctt     1560

cccagcttga tggtagtgat gcctcttgca caaatcaagc agccaatgac attggggacc     1620

atcaccaaac gaaccggcaa agttaaacct cctccacaaa tttcacccag caaatcgatg     1680

ggcggagaat tttgtgtggc tgctatcttc ggaacatcca ggtcatggtt tgcaaataat     1740

gcaggtctga aaagagaaaa agatcagtcc aaacaagttg tagttgagtc cctgtacatt     1800

atcagttgct atggcacctt agtggaacac atgatggagc cgcgacccct cagcactgca     1860

cccaagatta gtgacgacac accactggaa atgatgacat cgcctcgagc cagctggact     1920

ctggttagaa cccctcaatg gaatgaattg cagccaccgt ttaatgcaaa ccaccctctg     1980

ctcctcgctg cagatgcagt acagtattat cagttcctgc ttgctggcct ggttccccct     2040

ggaagtcctg ggcccattac tcgacatggg tcttacgaca gtttagcttc tgaccatagt     2100

ggacaggaag atgaagaatg gctttcccag gttgaaattg taacacacac tggaccccat     2160

agacgtctgt ggatgggtcc acagttccag ttcaaaacca tccatccctc aggccaaacc     2220

acagttatct catccagttc atctgtgttg cagtctcatg gtccgagtga cacgccacag     2280

cctcttttgg attttgatac agatgatctt gatctcaaca gtctcaggat ccagccagtc     2340

cgctctgacc ccgtcagcat gccagggtca tcccgtccag tctctgatcg aaggggagtt     2400

tccacagtga ttgatgctgc ctcaggtacc tttgacagga gcgtgaccct gctggaggtg     2460

tgcgggagct ggcctgaggg cttcgggctg cggcacatgt cctccatgga gcacacggag     2520

gagggcctcc gggagcgact tgccgacgcc atggccgagt cacctagccg ggacgtcgtg     2580

ggatccggaa cagacacagc ccttgacgta gcagtaaaaa ccttcccccc tgagagacac     2640

gtggcagtga agtgttttga acttcagcga gagggaagca tcgagactct gagtaacagc     2700

tcaggctcca ccagcggcag cataccaaga aactttgatg gctaccgatc tccgctgccc     2760

accaatgaga gccagcccct cagcctcttc ccgactggct tcccgtag                  2808


<210> 2650
<211> 1226
<212> DNA
<213> Homo sapiens

<400> 2650
gggcccagcc cgaggaggca ctcagggtta ggaggtctgg gcgagaagca actagggccc       60

tcatcacttc gccgccgaat ccccggcgcc gcccagcggg gcagagccag gccagggccg      120

cccgcccaac ctggtccgct gcctcttcgg ccatggaagc tgccggcagc cctgcggcta      180

cggagacagg caagtatatc gcgtcaacac agcgacctga cgggacctgg cgcaagcagc      240

ggagggtgaa agaaggatat gtgccccagg aggaggtccc agtatatgaa aacaagtatg      300

tgaagttttt caagagtaaa ccagagttgc ccccagggct aagccctgag gccactgctc      360

ctgtcacccc atccaggcct gaaggtggtg aaccaggcct ctccaagaca gccaaacgta      420

acctgaagcg aaaggagaag aggcggcagc agcaagagaa aggagaggca gaggccttga      480

gcaggactct tgataaggtg tccctggaag agacagccca actccccagt gctccacagg      540

gctctcgggc agcccccaca gctgcatctg accagcctga ctcagctgcc accactgaga      600

aagccaagaa gataaagaac ctaaagaaga aactccggca ggtggaagag ctgcagcagc      660

ggatccaggc tggggaagtc agccagccta gcaaagagca gctagaaaag ctagcaagga      720

ggagggcgct agaagaggag ttagaggact tggagttagg cctctgaggc ctttggggaa      780

tagggaatgg actgcagaac aaaccgtggg gctctctggg gtctggggga atacgggcaa      840

cagcagtcag gaggggtacc ccccatactg gcttacttcc acctcctgcg gcccagctct      900

gtcctccaga gcctagcgtc tccctcaatc cttccctttt cttcccaact tctacttttt      960

ggactttccc cctcccattc ccagtgttca aaatctcagt gactacccca ggtacctttg     1020

ctgctgattt gggtgtcttg tttaaaagaa aatcaggtgg gtgggaatct cttggagaac     1080

tgaggctgag ggtagaggga gtatgcccaa gtcttggagt cttggttcct gttcgcggtg     1140

tttatgggtt atttccctct ccatccctca tttttttttt ttttttaaaa aaagcaaaaa     1200

tgagaataaa cacaagtaga catgtc                                          1226


<210> 2651
<211> 847
<212> DNA
<213> Homo sapiens

<400> 2651
gcgggcgctg cggcccctgc tctacctcct agcgccggtg cgcggccgag gccgcactac       60

ctgtctgcgg gaaagcggga tccaccccag gacgtcgggt cgctgccgac ataatgtcaa      120

gtggaaacta tcagcagtca gaggctctta gcaaacccac tttcagtgag gaacaagcct      180

ctgcgttagt ggagtcagtg tttgggttga aagtttccaa ggtccggcca cttcctagct      240

atgatgacca aaactttcat gtctacgttt caaaaaccaa agatggccca actgaatatg      300

tcctcaaaat aagcaacacc aaggctagca aaaatccaga cctgattgaa gtgcagaatc      360

acatcatcat gtttctgaaa gccgctggat ttccaacagc ctctgtgtgt cacactaaag      420

gagacaacac agcttctctc gtgtctgtag atagtggctc tgaaatcaaa agctacttgg      480

tgaggctgct gacttacctc ccaggaagac ccatcgctga gcttcccgtc agcccccagc      540

tattgtatga aattggaaaa ctagctgcca aattggataa gacactgcag agattccatc      600

acccaaagtt aagtagtctt catcgggaga acttcatctg gaatctgaaa aatgttcctc      660

ttctggagaa atacctgtat gccctgggcc agaatcgaaa ccgagagatt gttgagcatg      720

tcattcatct gttcaaggag gaagtaatga ccaaattaag tcattttcga gaatgaccta      780

gcaccgtgcc aggcccctag aagacccagt aaagatctgt tgaataaact gtaagaatga      840

acacacc                                                                847


<210> 2652
<211> 663
<212> DNA
<213> Homo sapiens

<400> 2652
atggtagctg tgtgcaaggg gagagcagca gggtttagaa ttccaggaag gaagagagag       60

tgatgtcatc agattccatg gaccagccca ggaacccctg tgagaacgag cctctgactc      120

caggttatca tggattccca gcgcgggaca gccagggtaa ccaggagccg acaacaactc      180

ctgacgcaat ggttcagcct tttactacca tcccatttcc accacctccg cagaatggaa      240

ttcccacaga gtatggggtg ccacacactc aagactatgc cggccagacc ggtgagcata      300

acctgacact ctacggaagt acgcaagccc acggggagca gagcagcaac tcacccagca      360

cacaaaatgg atctcttacg cagacagaag gtggagcaca gacagacggc cagcagtcac      420

agacacaaag tagtgaaaat tcagagagta aatctacccc gaaacggctg catgtctcta      480

atattccttt ccgcttccgg gaccctgacc tccggcagat gtttgggcag tttggcaaaa      540

tcctagatgt agaaataatc tttaatgaac gtggctctaa gggattcggg ttcgtaactt      600

tcgagaatag tgctgatgca gacagggcca gggagaaatt acacggcacc gtggtagagg      660

gcc                                                                    663


<210> 2653
<211> 998
<212> DNA
<213> Homo sapiens

<400> 2653
cgcgctcttc ctttccaact tggacgctgc agaatggctc ccgcaaagaa gggtggcgag       60

aagaaaaagg gccgttctgc catcaacgaa gtggtaaccc gagaatacac catcaacatt      120

cacaagcgca tccatggagt gggcttcaag aagcgtgcac ctcgggcact caaagagatt      180

cggaaatttg ccatgaagga gatgggaact ccagatgtgc gcattgacac caggctcaac      240

aaagctgtct gggccaaagg aataaggaat gtgccatacc gaatccgtgt gcggctgtcc      300

agaaaacgta atgaggatga agattcacca aataagctat atactttggt tacctatgta      360

cctgttacca ctttcaaaat ttctgtgcta aacagtgtta cagtcgccaa gagcccataa      420

agggagccct cctggaagtg gatgaggcct tgggtctcgg ctcttcattg cttcctgagc      480

tgcagcagat gcctttacaa ccaagctcac cgaggacgtc tgtctcccat attaccctgg      540

cagagggcca ggcctgttct acacggccgg ggtttcaaca aggtactgat gtcttctgcc      600

cttgcctctt cgacaggcaa gtaataagac ttaagtgaag agaattcttt aggcacacaa      660

attcacattt gatgtaatct cattatactt cctgatctgt gattgaaaac tttcatttcg      720

taactagtat gtctgtccca cctttaaaaa gtttttcatt atgaaagtaa gtatttgtta      780

gaattaagtc tatttaaatg aaaaaaactt agatatgagt ctgcatggcc tcaggaaaat      840

gatgttttaa aatagagatt ttaggttgtc tgcactctag cttttttgtc gttttcttaa      900

ggctttttta actgcatcaa aaattcagat acgaaacata cactaaaaaa taatacatca      960

tatcttaatt tccactgaac ttgatttaaa ttcagagt                              998


<210> 2654
<211> 817
<212> DNA
<213> Homo sapiens

<400> 2654
ctttccaact tggacgctgc agaatggctc ccgcaaagaa gggtggcgag aagaaaaagg       60

gccgttctgc catcaacgaa gtggtaaccc gagaatacac catcaacatt cacaagcgca      120

tccatggagt gggcttcaag aagcgtgcac ctcgggcact caaagagatt cggaaatttg      180

ccatgaagga gatgggaact ccagatgtgc gcattgacac caggctcaac aaagctgtct      240

gggccaaagg aataaggaat gtgccatacc gaatccgtgt gcggctgtcc agaaaacgta      300

atgaggatga agattcacca aataagctat atactttggt tacctatgta cctgttacca      360

ctttcaaaag tcttcaaaac gatgatctct tcaaaacaga ttgtcaccat cagtgagaaa      420

ccgaacaaga agaggaaagc aaatggcatt ttcttctcta cttggtgaaa agtcattata      480

gaggattcga acggttccaa tgctcgcaat tctacttcaa gcatgtgctc attctacata      540

tcaacccctt tttcactgac aaatgtaatg ttgacaatct aggctaatgg gactagattt      600

tgaatccaat caacactttt tcatataaag ttttcagaat aacaaagctt tccctcattc      660

atacagatat tgctgtacta atctataatt atgttttaga attcaaatta taacactgac      720

taaacatcac taatgaaaca tttgtgacct ccttttttcc gaagtttaat ttttgctttg      780

aattcatatt ttatcagtat gtgttaatat aatgtca                               817


<210> 2655
<211> 1845
<212> DNA
<213> Homo sapiens

<400> 2655
atctggcttt gttttttctt tacgtcactt agcgccagtt tgttctggcc gtgtctccca       60

ctagaatgag ttaagcccag agtcaacaca tccagatttc cgaatgtggc taacgagtta      120

cccatctcca aatttccctg tgtcagtact gcagaatgga gtgaaaatga ccaatgaagc      180

accaaaaggt ttacgggcta atatcattcg atcatacctc atggacccga tctctgatcc      240

ggagttcttt ggcagctgca aaaagcctga ggaattcaag aaattgcttt atggcctgtg      300

tttctttcat gctttggtac aagaaagacg gaaatttgga cccctagggt ggaatattcc      360

ttatgagttc aatgagacag atctgagaat cagcgtacag cagctccaca tgttcctgaa      420

ccagtatgag gaactgccgt atgaggctct gcggtacatg actggcgaat gcaattacgg      480

aggcagagtg accgatgact gggaccggcg cacgctgcgc agcattctaa acaaattctt      540

caatcccgaa ttagttgaaa attcagacta taagttcgac tcaagtggca tctattttgt      600

tcctccttct ggtgatcaca aaagctacat cgaatacaca aagactctgc cactgacccc      660

agcaccagaa atctttggga tgaatgccaa tgcagatatc actaaggatc agtcagaaac      720

tcagctgcta tttgataaca ttcttcttac acagtctcgt tcagcaggtg ctggtgcaaa      780

atcatcagat gaagtagtga atgaggtcgc tagtgacatc ttgggcaaac ttccaaacaa      840

cttcgacatc gaggctgcca tgaggaggta cccaacaact tatactcaga gcatgaacac      900

tgtacttgtc caagagatgg gacggttcaa taagttactg aagaccataa gagattcgtg      960

cgtaaatatt caaaaagcaa tcaaggggct tgcagtcatg tctacagatc ttgaagaagt     1020

ggttagcagc attttgaatg tcaaaattcc agaaatgtgg atgggtaaat cctacccaag     1080

ccttaaacca cttggcagct atgtgaatga cttccttgca agactaaaat tcttgcagca     1140

atggtatgag gttggtcctc ctccagtctt ctggctttct ggcttcttct tcacacaagc     1200

cttcctgacc ggtgcccagc agaactacgc caggaaatac acaattccta ttgatcttct     1260

tgggtttgac tatgaagtga tggaagacaa agaatacaag catcctcctg aggatggtgt     1320

tttcattcac ggattatttc tggatggagc ttcctggaat agaaagatca agaaacttgc     1380

agaatcgcat cccaaaattc tttatgatac agtgcctgtg atgtggctaa agccctgtaa     1440

gagggcagat ataccaaaac ggccaagtta tgttgctcca ttgtataaga caagtgagcg     1500

gagaggagta ttatccacca ctggccattc cacgaatttt gtgattgcca tgactcttcc     1560

ctctgaccaa cccaaggaac actggattgg acgaggtgta gcactgttat gtcaacttaa     1620

ttcataacca gaagacatca tttccttgtt cctatttctt gttggctggc tgagtagaga     1680

aagcatattt tactacttaa accttttttt ttgtttgttt aaatacattt gactaaagtt     1740

ataattatga atttacttat gagcaaatgc agctaaactt aatatgactc atacttaaat     1800

gtaaggaaat gttctgaaat aaagactaaa gaaaacacac tggca                     1845


<210> 2656
<211> 1783
<212> DNA
<213> Homo sapiens

<400> 2656
gcgctgcccg gctcccggcc ctgccggcct cctcccttgg cgccgcggcc atggcggcca       60

gcgcgaagcg gaagcaggag gagaagcacc tgaagatgct gcgggacatg accggcctcc      120

cgcacaaccg aaagtgcttc gactgcgacc agcgcggccc cacctacgtt aacatgacgg      180

tcggctcctt cgtgtgtacc tcctgctccg gcagcctgcg aggattaaat ccaccacaca      240

gggtgaaatc tatctccatg acaacattca cacaacagga aattgaattc ttacaaaaac      300

atggaaatga agtctgtaaa cagatttggc taggattatt tgatgataga tcttcagcaa      360

ttccagactt cagggatcca caaaaagtga aagagtttct acaagaaaag tatgaaaaga      420

aaagatggta tgtcccgcca gaacaagcca aagtcgtggc atcagttcat gcatctattt      480

cagggtcctc tgccagtagc acaagcagca cacctgaggt caaaccactg aaatctcttt      540

taggggattc tgcaccaaca ctgcacttaa ataagggcac acctagtcag tccccagttg      600

taggtcgttc tcaagggcag cagcaggaga agaagcaatt tgacctttta agtgatctcg      660

gctcagacat ctttgctgct ccagctcctc agtcaacagc tacagccaat tttgctaact      720

ttgcacattt caacagtcat gcagctcaga attctgcaaa tgcagatttt gcaaactttg      780

atgcatttgg acagtctagt ggttcgagta attttggagg tttccccaca gcaagtcact      840

ctccttttca gccccaaact acaggtggaa gtgctgcatc agtaaatgct aattttgctc      900

attttgataa cttccccaaa tcctccagtg ctgattttgg aaccttcaat acttcccaga      960

gtcatcaaac agcatcagct gttagtaaag tttcaacgaa caaagctggt ttacagactg     1020

cagacaaata tgcagcactt gctaatttag acaatatctt cagtgccggg caaggtggtg     1080

atcagggaag tggctttggg accacaggta aagctcctgt tggttctgtg gtttcagttc     1140

ccagtcagtc aagtgcatct tcagacaagt atgcagctct ggcagaacta gacagcgttt     1200

tcagttctgc agccacctcc agtaatgcgt atacttccac aagtaatgct agcagcaatg     1260

tttttggaac agtgccagtg gttgcttctg cacagacaca gcctgcttca tcaagtgtgc     1320

ctgctccatt tggagctacg ccttccacaa atccatttgt tgctgctgct ggtccttctg     1380

tggcatcttc tacaaaccca tttcagacca atgccagagg agcaacagcg gcaacctttg     1440

gcactgcatc catgagcatg cccacaggat tcggcactcc tgctccctac agtcttccca     1500

ccagctttag tggcagcttt cagcagcctg cctttccagc ccaagcagct ttccctcaac     1560

agacagcttt ttctcaacag cccaatggtt ttgcagcatt tggacaaaca aagccagtag     1620

taaccccttt tggtcaagtt gcagctgctg gagtatctag taatcctttt atgactggtg     1680

caccaacagg acaatttcca acaggaagct catcaaccaa tcctttctta tagccttata     1740

tagacaattt actggaacga acttttatgt ggtcacatta cat                       1783


<210> 2657
<211> 2572
<212> DNA
<213> Homo sapiens

<400> 2657
ggtgcccccc gggcgcaggc cagggaggcc cgagcgcctt ccccacgccc cgctcgcccg       60

cgcgtgtgag gggagggcgg cccagccgtt tcgcgccggg agattttgtg gaagtataat      120

actttgtcat tatgagatgt cgtctctcgg tgcctccttt gtgcaaatta aatttgatga      180

cttgcagttt tttgaaaact gcggtggagg aagttttggg agtgtttatc gagccaaatg      240

gatatcacag gacaaggagg tggctgtaaa gaagctcctc aaaatagaga aagaggcaga      300

aatactcagt gtcctcagtc acagaaacat catccagttt tatggagtaa ttcttgaacc      360

tcccaactat ggcattgtca cagaatatgc ttctctggga tcactctatg attacattaa      420

cagtaacaga agtgaggaga tggatatgga tcacattatg acctgggcca ctgatgtagc      480

caaaggaatg cattatttac atatggaggc tcctgtcaag gtgattcaca gagacctcaa      540

gtcaagaaac gttgttatag ctgctgatgg agtattgaag atctgtgact ttggtgcctc      600

tcggttccat aaccatacaa cacacatgtc cttggttgga actttcccat ggatggctcc      660

agaagttatc cagagtctcc ctgtgtcaga aacttgtgac acatattcct atggtgtggt      720

tctctgggag atgctaacaa gggaggtccc ctttaaaggt ttggaaggat tacaagtagc      780

ttggcttgta gtggaaaaaa acgagagatt aaccattcca agcagttgcc ccagaagttt      840

tgctgaactg ttacatcagt gttgggaagc tgatgccaag aaacggccat cattcaagca      900

aatcatttca atcctggagt ccatgtcaaa tgacacgagc cttcctgaca agtgtaactc      960

attcctacac aacaaggcgg agtggaggtg cgaaattgag gcaactcttg agaggctaaa     1020

gaaactagag cgtgatctca gctttaagga gcaggagctt aaagaacgag aaagacgttt     1080

aaagatgtgg gagcaaaagc tgacagagca gtccaacacc ccgctgctgc cttcctttga     1140

gattggtgca tggacggaag acgatgtgta ttgttgggtt cagcagctcg tcagaaaagg     1200

tgactcttca gcagagatga gtgtatatgc aagcttgttt aaagaaaaca acattacagg     1260

gaagcggctg ctgctgctgg aggaagaaga cctgaaagac atgggcattg tctccaaggg     1320

gcatatcatt cacttcaagt cagccattga gaaattaacc catgattaca taaatttgtt     1380

tcacttccca ccactaatta aggactcagg aggtgaacct gaagaaaatg aggaaaaaat     1440

agtgaacctg gaactggttt ttggttttca cttgaaacca ggaactggcc cacaggattg     1500

taagtggaaa atgtatatgg agatggatgg ggatgaaatt gcaataacct acataaaaga     1560

tgtgacattc aacactaacc tacctgatgc ggagatttta aagatgacaa agccaccatt     1620

tgtaatggag aagtggattg taggaatagc aaaaagtcag actgtggagt gcactgtcac     1680

atatgagagt gatgttagaa ctccaaaaag cactaaacat gtccattcga ttcagtggag     1740

tagaacaaaa cctcaggatg aagtgaaagc agtccaactt gccattcaga cattattcac     1800

caattcagat ggcaaccctg gaagcaggtc cgactcaagt gctgattgcc agtggttaga     1860

tactctgagg atgcggcaga ttgcatccaa cacttcttta cagcgttccc agagcaatcc     1920

tattctgggg tcaccgttct tctcacactt tgatggccag gattcctacg ctgctgctgt     1980

gagacggccc caggtgccca ttaagtatca acagattaca cctgtgaacc agtccagaag     2040

ctcgtctcct actcagtatg gactgaccaa aaacttctct tccctacatc tcaactctag     2100

ggacagtggc ttttccagtg gcaatactga cacctcttca gagaggggtc gatactcaga     2160

cagaagcagg aacaaatatg gacgtggtag tatatcactc aattcttctc ctagaggaag     2220

atacagtgga aagagtcagc attccactcc ttcaagagga agataccctg gaaagttcta     2280

cagggtttct cagtcagcac tcaatcctca ccagtcgcct gacttcaaga gaagccccag     2340

ggacctccac caacccaaca ccataccagg gatgcctttg caccctgaga ctgactcaag     2400

agccagtgaa gaggacagca aagtcagcga agggggctgg acaaaagtgg aataccggaa     2460

aaagccccac aggccatctc ccgccaaaac caataaagag agagccagag gggaccaccg     2520

tggatggaga aacttttgat gaattgaact acatagcttt tctaagcagg tt             2572


<210> 2658
<211> 689
<212> DNA
<213> Homo sapiens

<400> 2658
gcggcggcgc ctgacgaggg tgccgcggcc gctgggcgca gcgttcgggg gttgcacggc       60

ccgcggcggc gacgaaaaca acgaccagga cgctcggcgc ccctgtccgc agagtcgcca      120

ctcccgcctc ttctccggtc tctagcgacg cgggcccgcg gcttcctcct ttcctgccca      180

gttcccgcgg gcctcggggt tgcagcggct agaagtgccg aggagcgcca ggaggacccg      240

gccggctgcg aggattcacg cgcccgccac cccgcccggc ccgggcttca tgtgaaagag      300

ggacgggcct ggccccaagg cccgcgcccg actcctcgcg cgcccctccg gtccccgggg      360

gccctgcggc agcccccgac ctggggccgc ggtgacaggc cgcgctgggg cggaggggcg      420

ggctcggcgg gggcggcccc tccttgggcc tgcggctctc tacgtccctg cggagcagcc      480

ggccataaag aatgctgatg ggagaaccat tttcctaatt ttcaaattgt tgagctgttt      540

gccataatgg atgatcagca agctttgaac tcaatcatgc aagatttggc tgtccttcat      600

aaggccagtc gaccagcatt atccttgcag gaaaccagaa aagcaaaatc ttcatcacca      660

aaaaaacaga atgatgtccg agtcaaatt                                        689


<210> 2659
<211> 2455
<212> DNA
<213> Homo sapiens

<400> 2659
cgggtgggga ggtggggtcc gggtgtgcgc cgcggcgctg gctgcgaagg cagtggccga       60

ggcgggctcc ctctgggccg tgcccggcct ggctaacaaa gccgccgcgg cctctgttgt      120

gtgatggtgt cttttatgaa taatcaaaag cagcaaaagc caacgctatc aggccagcgt      180

tttaaaacta gaaaaagaga tgaaaaagag aggtttgacc ctactcagtt tcaagactgt      240

attattcaag gcttaactga aaccggtact gatttggaag cagtagctaa gtttcttgat      300

gcttctggag caaaacttga ttaccgtcga tatgcagaaa cactctttga cattctggtg      360

gctggtggaa tgctggcccc aggtggtaca ctggcagatg acatgatgcg tacagatgtc      420

tgcgtgtttg cagcccaaga agatctagag accatgcaag catttgctca ggtttttaac      480

aagttaatca ggcgctacaa atacctggag aaaggttttg aagatgaagt aaaaaagctg      540

ctgctgttct tgaagggttt ttcagagtcg gagaggaaca agctagctat gttgactggt      600

gttcttctgg ctaatggaac acttaatgca tccattctta atagccttta taatgaaaat      660

ttggttaaag aaggagtttc agcagctttt gctgtgaagc tctttaaatc atggataaat      720

gaaaaagata tcaatgcagt agctgcaagt cttcggaaag tcagcatgga taacagactg      780

atggaactct ttcctgccaa taagcaaagt gttgaacact tcacaaaata ttttactgag      840

gcaggcttga aagagctttc agaatatgtt cggaatcagc aaaccatcgg agctcgtaag      900

gagctccaga aagaacttca agaacagatg tcccgtggtg atccatttaa ggatataatt      960

ttatatgtca aggaggagat gaaaaaaaac aacatcccag agccagttgt catcggaata     1020

gtctggtcaa gtgtaatgag cactgtggaa tggaacaaaa aagaggagct tgtagcagag     1080

caagccatca agcacttgaa gcaatacagc cctctacttg ctgcctttac tactcaaggt     1140

cagtctgagc tgactctgtt actgaagatt caggagtatt gctatgacaa cattcatttc     1200

atgaaagcct tccagaaaat agtggtgctt ttttataaag ctgaagtcct gagcgaggag     1260

cccattttga agtggtataa agatgcacat gttgcaaagg ggaagagtgt tttccttgag     1320

caaatgaaaa agtttgtaga atggctcaaa aatgctgaag aagaatctga atctgaagct     1380

gaagaaggtg actgaatttt gaaactacac cctcagtaaa gcaaacagga gttgtagata     1440

aaatgtcatg tctcatgtgt cctggttctt acatcttcct acctccctgt atcaagcatg     1500

atataagggc tttcatggca aattttattt taactgtttc tatggttgct ggaaatgttg     1560

ggtttagttt ctaaaaccat gttttaagta gctacaggag ctatagattt gaatctaatg     1620

ttgcattagt cttttcagtt atcttctacc tcctgtattt tctactgtaa taatgtaatt     1680

taaggccttc cacaatgaac agttcacttt attccctggg ttttctataa acagttttaa     1740

ggatatgatt tggttaaaaa ataatttgtt ataaaaattc tgtttgcaaa ttaaactgga     1800

aaagtatcca gagtctcaaa aggcaatgat ttgtgagata atatggcatg cccggagccc     1860

tgctcatcaa tgaaaaaccc atatgtaata atcgaattca tttaacatga atcttgagta     1920

cgtggaccat tgcttgcatg ttaacttttt gttttgtttt gttttgtttt gttttgcatt     1980

tttaactcca gatatcctaa agctcaattg tttggtctct ggttttcatc cttagagaag     2040

ccatggagaa cagacttgaa aagtttagga aatcataatg tggcagaggt ggtgggaaga     2100

agaaagttga gctttttccc cttgagaaac ttctgcattt agtttctatc tttccaggca     2160

aaacaaatgg gtattctttt catacaacca ttttcaaatg aaccttagaa aagtcttaac     2220

atttaaggta ttttatgcac agaatacact tagattgata ggaaagaact cgtaatggag     2280

tttgagtaaa gaaaatgact gatgtactaa acccagtaaa aattgttgaa aatgttaaag     2340

gtcagcatgt tctaattggg aatctagata tagcttagat ttcctattgg cttagagtat     2400

ttgctataac aaatgaagtg caatgacaat tatatattcc tactcggtca tactg          2455


<210> 2660
<211> 1441
<212> DNA
<213> Homo sapiens

<400> 2660
ctctttctct ctcacagctt ctcacgaggt agaactttag agcctggtgt gtttgtggct       60

ggagcatagc agctcttcta caactttact gtagtttcta ctgaatattt tggtttgcaa      120

atataaagga ttctctgaag cacaacctta aataacgtgt ggtagacacc tgggagagga      180

aaactgcaga cagaaaaatg tggccggatg ctctgtgggc gggcggcagc gatgttcggc      240

caggtggctc caaggagagg aagcagtgat gcattgaggt aaaaataagt gactaaagaa      300

gcagacctgg gaatcaccta acatgtcgag gaggagattt gattgccgaa gtatttcagg      360

cctactaact acaactcctc aaattccaat aaaaatggaa aactttaata atttctatat      420

acttacatct aaagagctag ggagaggaaa atttgctgtg gttagacaat gtatatcaaa      480

atctactggc caagaatatg ctgcaaaatt tctaaaaaag agaagaagag gacaggattg      540

tcgagcagaa attttacacg agattgctgt gcttgaattg gcaaagtctt gtccccgtgt      600

tattaatctt catgaggtct atgaaaatac aagtgaaatc attttgatat tggaatatgc      660

tgcaggtgga gaaattttca gcctgtgttt acctgagttg gctgaaatgg tttctgaaaa      720

tgatgttatc agactcatta aacaaatact tgaaggagtt tattatctac atcagaataa      780

cattgtacac cttgatttaa agccacagaa tatattactg agcagcatat accctctcgg      840

ggacattaaa atagtagatt ttggaatgtc tcgaaaaata gggcatgcgt gtgaacttcg      900

ggaaatcatg ggaacaccag aatatttagc tccagaaatc ctgaactatg atcccattac      960

cacagcaaca gatatgtgga atattggtat aatagcatat atgttgttaa ctcacacatc     1020

accatttgtg ggagaagata atcaagaaac atacctcaat atttctcaag ttaatgtaga     1080

ttattcggaa gaaacttttt catcagtttc acagctggcc acagacttta ttcagagcct     1140

tttagtaaaa aatccagaga aaagaccaac agcagagata tgcctttctc attcttggct     1200

acagcagtgg gactttgaaa acttgtttca ccctgaagaa acttccagtt cctctcaaac     1260

tcaggatcat tctgtaaggt cctctgaaga caagacttct aaatcctcct gtaatggaac     1320

ctgtggtgat agagaagaca aagagaatat cccagaggat agcagcatgg tttccaaaag     1380

atttcgtttc gatgactcat tacccaatcc ccatgaactt gtttcagatt tgctctgtta     1440

g                                                                     1441


<210> 2661
<211> 1730
<212> DNA
<213> Homo sapiens

<400> 2661
cggggctctg gccatataaa cagagggacg cacgcccatg cggctgtaga cgccatgatg       60

gatgtgtctg gtgtgggttt cccaagcaag gttccttgga agaagatgtc tgcagaggag      120

ctggagaatc agtactgtcc cagccgatgg gttgtccgac tgggagcaga ggaagccttg      180

aggacctact cacagatagg aattgaagcc accacaaggg cccgggccac caggaagagc      240

ctgctgcatg tcccctatgg agacggcgaa ggggagaaag tggacattta cttccccgac      300

gagtcgtctg aagccttgcc tttcttcctg ttctttcacg gaggatactg gcagagcgga      360

agtaaggatg agtctgcctt catggtccac ccgctgacgg cacagggagt ggccgtggta      420

atagtggctt acggcatcgc ccccaaaggc accctggacc acatggtaga ccaggtgacc      480

cgcagcgttg cgtttgtcca gaagcggtat ccaagcaaca agggaattta cctgtgtgga      540

cactcagccg gggcccacct ggctgccatg atgctcctgg ccgactggac caagcatggg      600

gtcacgccca acctcagagg ctttttcctg gtgagtgggg tctttgacct ggagcccatc      660

gtgtatactt cacagaacgt tgctctccag ctgaccctgg aggacgctca gaggaatagc      720

ccccagctga aggtggccca ggcacagccg gtggacccca cctgccgtgt gctggtggtc      780

gtgggccagt tcgactcccc cgaattccac cgacagtcct gggagtttta ccagaccctg      840

tgtcaaggag agtggaaagc ctcatttgaa gagctccacg atgtggacca ctttgaaatt      900

gttgagaatc tgacccagaa ggacaacgtg ctcacccaga ttatcttgaa aacaatcttc      960

cagtagttct gacgatactt ggagcctggt ccacgtgcat cccaccttgg gaagcctctc     1020

caaagagctt tcggagctga cactgacagc ttcagtttcc cccagcaccc aggagagcct     1080

tgctgtgtct gtctgcccgg caagagtcca ttctcactgc tgggacactc atgaaaatct     1140

ccacgtcctc cctcttccca gcctggatgg agctccaggg ctggggaacg tccgcaagtc     1200

aatgctcaga gatgcccgga gctgcctctt agactcgtct ggcccatcta cctgctgaca     1260

gagcatgaca aagatgacgc tcaaaagtaa tgccattact tctttttttt tttttttttt     1320

tttttttttt gagatggagt cttactctgt cacccaggct ggagtgcagt ggcgtgatct     1380

tggctcactg caacctccac ctcccgggtt caagcaattc tcctgcctca gcctcctgag     1440

cagctgggac tacaggcgcc tgccatcatg cctggctaat ttttgtattt ttagtagaga     1500

cggggtttca acatattggc caggctggtc tcaaactcct aaccttgtga ttcgcccgcc     1560

ttggcctccc aaagtgctgg gattccaggc gtgagccact gcgcccggcc agaatggcat     1620

tatatttaaa tagttcataa agaagcacaa aagaatatta tttcataaca tgtaaaaatt     1680

atataaaacg taaatttcca tgttgataaa taaagttgta ttggaacacg                1730


<210> 2662
<211> 1045
<212> DNA
<213> Homo sapiens

<400> 2662
tttctccctg tttgctggcc cagacaggcc tgtgctagag ggctggatag tgtggtagtg       60

tggtggatag agtgctgcct ctatccacaa cgcagccata tgctgactga agataacttt      120

gtgtctggaa gagccctctg atttcttaca ctaatggcct tacacgacat ggaggatttt      180

acatttgatg gaacaaagcg cttaagtgtc aactacgtga agggaattct tcaaccgaca      240

gacacctgtg acatctggga taagatctgg aacttccaag ccaagcctga tgacctgctt      300

atttctacct atcctaaagc aggaacaaca tggactcagg agatagtgga attaatacaa      360

aatgaaggtg atgtggagaa aagtaaacgg gcaccgactc atcaacgatt tcctttcctc      420

gaaatgaaaa tcccatcctt aggatctgtg tgctggggct cctggcatga acatgtgaaa      480

ggatggtggg aagccaaaga caaacaccgt attctctatc tcttctatga ggacatgaag      540

aagaacccaa agcatgaaat tcagaagctg gcagaattta ttgggaagaa attagatgac      600

aaagttctag ataaaattgt ccattacact tcgtttgatg tcatgaaaca gaatccaatg      660

gcaaactatt catcgattcc tgctgaaatc atggaccact ccatttctcc attcatgaga      720

aaaggggcag tgggagactg gaagaaacac ttcaccgtgg ctcagaatga gagatttgat      780

gaagattaca agaagaaaat gactgatacc agactaactt tccacttcca gttctagtaa      840

ggaagaaaaa ctgaaaatgt tttagtttat tacccagtat atttgggtaa taatgaaagt      900

ttaattctca taacaaatga tatcagattc cagttatcag aatagtttac tgtgtttgct      960

cttattcact ctactaaaaa attattttaa aaggctggag gcaaggtggt gacaggcagc     1020

agggtggcga catggagaga gggaa                                           1045


<210> 2663
<211> 716
<212> DNA
<213> Homo sapiens

<400> 2663
ctttccaact tggacgctgc agaatggctc ccgcaaagaa gggtggcgag aagaaaaagg       60

gccgttctgc catcaacgaa gtggtaaccc gagaatacac catcaacatt cacaagcgca      120

tccatggagt gggcttcaag aagcgtgcac ctcgggcact caaagagatt cggaaatttg      180

ccatgaagga gatgggaact ccagatgtgc gcattgacac caggctcaac aaagctgtct      240

gggccaaagg aataaggaat gtgccatacc gaatccgtgt gcggctgtcc agaaaacgta      300

atgaggatga agattcacca aataagctat atactttggt tacctatgta cctgttacca      360

ctttcaaaag taagttctcc atcccataaa gccatttaaa ttcattagaa aaatgtcctt      420

acctcttaaa atgtgaattc atctgttaag ctaggggtga cacacgtcat tgtacccttt      480

ttaaattgtt ggtgtgggaa gatgctaaag aatgcaaaac tgatccatat ctgggatgta      540

aaaaggttgt ggaaaataga atgcccagac ccgtctacaa aaggttttta gagttgaaat      600

atgaaatgtg atgtgggtat ggaaattgac tgttacttcc tttacagatc tacagacagt      660

caatgtggat gagaactaat cgctgatcgt cagatcaaat aaagttataa aattgc          716


<210> 2664
<211> 572
<212> DNA
<213> Homo sapiens

<400> 2664
ctttctttcc gcgccgatag cgctcacgca agcatggtta acgtccctaa aacccgccgg       60

actttctgta agaagtgtgg caagcaccaa ccccataaag tgacacagta caagaagggc      120

aaggattctc tgtacgccca gggaaagcgg cgttatgaca ggaagcagag tggctatggt      180

gggcaaacta agccgatttt ccggaaaaag ctacaccaaa attgcattga gccaaacttg      240

ccaccaagag cccaacaatc accatgatgc tgagcacgga aggcagggag gggttcgtgg      300

tgaaggtcag gggcctaccc tggtcctgct cagccgatga agtgatgcgc ttcttctctg      360

attgcaagat ccaaaatggc acatcaggta ttcgtttcat ctacaccaga gaaggcagac      420

caagtggtga agcatttgtt gaacttgaat ctgaagagga agtgaaattg gctttgaaga      480

aggacagaga aaccatggga cacagatacg ttgaagtatt caagtctaac agtgttgaaa      540

tggattgggt gttgaagcat acaggtccga at                                    572


<210> 2665
<211> 1447
<212> DNA
<213> Homo sapiens

<400> 2665
acttttcttg tcgggcaact aggtgccgag cagtgctgcg cccggaagct ggccgccact       60

gcggggaggt tgggccgagg cggcaggcgg gcgggctggg gcactggtgc ccggcctgct      120

cttccggagc tgcagcccct caatttggct gaggcggtgg cggccgccgt gaggcctgcg      180

gagctccgac ccaggggatt tctataattg gcctgatgaa tcctttgatg aaatggacag      240

tacactagct gttcaacagt atattcaaca gaacataaga gcagattgct ccaatattga      300

caaaattctt gaaccacctg aaggccaaga tgaaggtgtg tggaagtatg aacatttaag      360

gcagttctgc cttgagctaa atggacttgc tgtcaaactt cagagtgaat gccatccaga      420

tacttgcact caaatgacag caactgaaca atggattttt ctttgtgcag ctcataaaac      480

tccaaaagag tgtcctgcta tagactatac tagacacaca cttgatggtg ctgcatgtct      540

tctgaatagc aataaatatt ttcccagcag ggttagcata aaggaatcat ctgtagcgaa      600

actaggatca gtatgccgta ggatttacag aatattttca catgcttatt ttcatcatcg      660

gcagatattt gatgaatatg aaaatgaaac atttttgtgt catcggttta ctaagtttgt      720

gatgaaatac aatttgatgt ccaaggataa cctgattgta ccaattttag aagaggaagt      780

acagaattca gtttctgggg aaagtgaagc atgaagggaa tcataggaaa aatgtactga      840

tcatataatt aacattatgt actgtatata tcattttaga cacatcaatc atgtatccat      900

attatagctt ctttgtttag tataggtttt tgtatgctgg gtttgccttt taaaatggga      960

aatacttttt aagttattca taagctgtat attcaccagt gtggcactca tggtttttaa     1020

ataagattag tattatctgt ttataatgcc tgttaataaa agaatttaca gtttggtaaa     1080

attgctgcta aacaatcatt ggatcacaat cctcatcaga caaacccatc tgtaaaaaaa     1140

atgagggaga gcttgaggtt tcacacaagc catttactaa agaggtagaa atgttttcta     1200

ttggttttac cttgagttta gatatcctaa aaaattctgt agtacgtagt tttgtcttac     1260

ctgttaactt tccccaattg agataaaagt gttttaaaat tctgtttata gtttttgata     1320

tgcatatata attatgtgta tatctaaata caaatgcaaa tgaagcatta gtaatactta     1380

aataatttta ctgtgctaca taaagtataa catacttgga aaggatttac cgttctgcaa     1440

caacgga                                                               1447


<210> 2666
<211> 4502
<212> DNA
<213> Homo sapiens

<400> 2666
gggaagtccg gatcccgcgg cgatccgagc atgagcctgg agcgcgagct tcgccagctg       60

agcaaggcga aagccaaggc gcagagggcc gggcagcggc gcgaagaggc cgcgctgtgc      120

caccagctgg gggagctcct ggccggccat ggccgctacg ccgaggctct ggagcagcac      180

tggcaggagc tgcagcttcg ggagcgcgct gacgaccctc tgggctgtgc cgtggcccac      240

cgcaagatcg gagagcgcct ggccgagatg gaggactacc cggctgcctt gcagcaccag      300

caccagtacc tggagctggc acattccctg cgcaaccaca cggagctgca gagggcctgg      360

gccaccatcg gccgcaccca cctggacatc tatgaccact gccagtcgag ggatgctttg      420

ctgcaggcac aggctgcctt tgagaagagc ttggctattg tggatgagga gctggagggg      480

acactggccc agggagagct gaatgagatg aggacccgcc tctatctcaa cctgggcctc      540

acctttgaga gcctgcagca gacagccctg tgcaacgatt acttcaggaa gagcatcttc      600

cttgcggagc agaaccacct ttacgaggac ctattccgcg cccgctacaa cctgggcacc      660

atccactggc gcgcgggcca gcactcccag gctatgcgct gcttggaggg tgcccgggag      720

tgtgcgcaca ccatgaggaa gcggttcatg gagagcgagt gctgcgtggt tattgcacag      780

gtcctccaag acctgggaga ctttttggct gccaagcgag ccctgaagaa ggcctacagg      840

ctgggctccc agaagcctgt gcagagggca gccatctgtc agaacctcca gcatgtgctg      900

gcagtggtcc ggctgcagca acagctggaa gaggctgagg gcagagaccc tcagggtgcc      960

atggtcatct gtgagcagct aggggacctc ttctccaagg caggagactt tcccagggca     1020

gctgaggctt accagaagca gctgcgtttt gctgagctgc tggacagacc gggtgctgag     1080

cgggccatca tccacgtgtc cctggccacc acactgggag acatgaagga ccaccatggg     1140

gccgtgcgcc actatgagga ggaactgagg ctgcgcagcg gcaacgtgct ggaggaggcc     1200

aagacctggc tgaacattgc actgtcccgc gaggaggccg gcgatgccta cgagctgctg     1260

gccccgtgct tccagaaagc gctcagctgt gcccagcagg cccagcgtcc ccagctgcag     1320

aggcaggtct tgcagcatct ccataccgtg cagctgaggc tgcagcccca ggaggcccct     1380

gagaccgaaa ccagactacg ggagctcagt gtagctgaag atgaagatga ggaggaggag     1440

gcggaggagg cggcagccac agcggagagc gaagccctgg aggccggcga ggtggagctc     1500

tcagagggcg aggacgacac cgatggcctg accccgcagc tggaggagga cgaggagctt     1560

cagggccacc tgggccggcg gaaggggagc aagtggaacc ggcgaaacga catgggggag     1620

accctgctgc accgagcctg catcgagggc cagctgcgcc gcgtccagga ccttgtgagg     1680

cagggccacc cccttaaccc tcgggactac tgtggctgga cacctctgca cgaggcctgc     1740

aactacgggc atctagaaat tgtccgcttc ctgctggacc acggggccgc agtggacgac     1800

ccaggtggcc agggctgcga aggcatcacc cccctccacg atgccctcaa ctgtggccac     1860

ttcgaggtgg ctgagctgct gcttgaacgg ggggcgtccg tcaccctccg cactcgaaag     1920

ggcctcagcc cgctggagac gctgcagcag tgggtgaagc tgtaccgcag ggacctggac     1980

ctggagacgc ggcagaaggc cagggccatg gagatgctgc tccaggcggc tgcctcgggc     2040

caagatcccc acagctccca ggccttccac accccaagca gccttctgtt tgaccccgag     2100

acctctcctc ctttgagccc ctgcccagaa cccccctcta atagcactag actcccagag     2160

gcctctcagg cccatgtcag ggtctcccca gggcaggcgg caccagccat ggccaggcct     2220

cggaggagca ggcatgggcc agccagcagc agcagcagct cagaaggcga ggacagcgca     2280

ggccccgcac ggccgtccca gaagaggcct cggtgctcgg ccacagcaca acgggtggca     2340

gcctggacgc ctggccccgc cagcaacagg gaagcagcca cagccagcac cagccgggca     2400

gcctaccagg cagccatccg gggtgtgggc agtgctcaga gccggctggg gcctggccca     2460

ccgcggggcc acagcaaagc ccttgccccc caggcagcgc tcatcccgga ggaggagtgc     2520

ctggccgggg actggctgga gctggacatg cccctgaccc gcagccgccg gccccgcccc     2580

cggggcactg gagacaaccg caggcccagt agtacctctg ggtcggacag tgaggagagc     2640

aggccccgtg cccgagccaa gcaggtccgc ctgacctgca tgcagagttg cagtgcgcca     2700

gttaacgcag ggcccagcag cctggcttca gaacctccag ggagccccag cacccccagg     2760

gtctcagagc ccagtgggga cagctctgcg gcaggccagc ccttgggtcc ggccccgccc     2820

cctcccatcc gggttcgagt tcaagttcag gatcatctct tcctcatccc tgtcccacac     2880

agcagtgaca cccactctgt ggcctggctg gccgagcagg cggcccagcg ctactaccag     2940

acctgcgggc tgctgcccag gctcacccta cggaaagagg gggccctgct ggccccacag     3000

gacctcatcc ctgatgtgct gcagagcaat gacgaggtgt tggctgaggt gacttcgtgg     3060

gacctgcccc cgttgactga ccgctaccgc agggcctgcc agagcctggg gcaaggggag     3120

caccaacagg tgctgcaggc cgtggagctc cagggcttgg gcctctcgtt cagcgcctgc     3180

tccctggccc tggaccaggc ccagcttaca cccctgctgc gggccctcaa gctgcacaca     3240

gcactccggg agctgcgcct ggcagggaac cggctggggg acaagtgtgt ggctgagctg     3300

gtggctgccc tgggcaccat gcccagcctg gccctccttg acctctcctc caatcacctg     3360

ggtcccgaag gcctgcgcca gcttgccatg gggctcccag gccaagccac cttgcagagt     3420

ttggaggagc tggacttaag catgaacccc ctgggggacg gctgtggcca gtccctggcc     3480

tccctcctgc acgcctgccc cttactcagc accctgcgcc tgcaggcgtg tggcttcggc     3540

cccagcttct ttctgagcca ccagacagca ctgggtagtg ctttccaaga tgctgagcac     3600

ctgaagaccc tgtccctgtc ctacaacgcc ctgggagccc ctgccctggc caggaccctg     3660

cagagcctgc ccgccggcac cctcctgcac ttagagctca gctccgtggc agccggcaag     3720

ggtgattcgg acctcatgga gcctgtattc cgatacctgg ccaaggaagg ctgtgctcta     3780

gcccacctga ccctgtctgc aaaccacctg ggggacaagg ctgttagaga cctgtgcaga     3840

tgtctctctc tgtgcccctc actcatctca ctggatctgt ctgccaaccc tgagatcagc     3900

tgtgccagct tggaagagct cctgtccacc ctccaaaagc ggccccaagg ccttagcttc     3960

cttggcctgt caggctgcgc cgtccagggt cccctgggcc tgggcctgtg ggacaagata     4020

gccgcgcagc tccgggaact gcagctgtgc agcagacgcc tctgcgctga ggacagggac     4080

gccctgcgcc agctgcagcc cagtcggccg ggccccggcg agtgcacgct ggaccacggc     4140

tccaagctct tctttcggcg cctctgaccc tggcgctgcc tttccccacc ctcaccgaag     4200

cccctaataa atgaagctgc tggccgggcg cggtggctca cgcctgtaat cccaacactt     4260

tgggaggccc aggcgggcgg atcacgaggt caggagatcg agaccatcct ggctaacatg     4320

gtgaaacccc gtctctacta aaaataccaa aaattagccg ggcgtggtgg tggaagcctg     4380

tagtcccagc tactccggag gctgaggcag gagaatggcg tgaacccggg aggcggagct     4440

tgcagtgagc cgagatcgca ccactgcact ccagcctggg cgacagaccg agactccgtc     4500

tc                                                                    4502


<210> 2667
<211> 2165
<212> DNA
<213> Homo sapiens

<400> 2667
ggcgctcgga gcgggctccg cggcttgcaa ggcgcctgcg actcggtccc aggtcggcgg       60

gcggcgcacg gcgggctcgc gcgggggccc cggcgcgccg ggcggcgcag tacgcagcgc      120

gcggacccac gccacggcca ggagcccaga gcagcgcggc cacactgccc aggggtcggc      180

cctcggcccc ggcgctcgga gcgcggcggc tgcctgggct ttaatggctg ctccgcggag      240

cagcgcctag ggctggaagg cggctgcggc tcaggaagtc acccgagcaa gcctccttcg      300

gggccggccg cacccgccgc ggcgcgctcc atgggggcgc gctccccccg ggcggcccgc      360

tgacccggga cgccggggcc cgctcgctcg ccggccgcgc gtcccggcca tgaactgagc      420

ccgcgggcca gccccgcgcc tgctccgccc gcgcctttct tctcgcgcct cctccgcccg      480

ccgccggcgg gcccggctcc ccgggggctg cggcgccccg ggctcggcgg cccgcgggcc      540

ccggggcgcg gggcggcggc ggcggggggc gcgcggctcc gggcgcggcg cctgcaccat      600

gaactaccag cagcagctgg ccaactcggc tgccatccgg gccgagatcc agcgcttcga      660

gtcggtccac cccaacatct actccatcta cgagctgctg gagcgcgtgg aggagccggt      720

gctgcagaac cagatccggg agcacgtcat cgccatcgaa gatgccttcg tgaacagcca      780

ggaatggacg ctgagtcgat ctgtcccgga gctcaaagtg ggaattgtgg gtaacttggc      840

cagcggcaag tctgccctgg tgcaccggta cctgacgggc acatatgtcc aggaggagtc      900

tccggaaggt ggcaggttca agaaagagat tgtcgttgat ggacagagct atctgctgct      960

gatcagagat gaagggggcc ccccggaggc gcagtttgcc atgtgggtgg acgctgttat     1020

atttgtcttc agcttggagg atgaaataag tttccagacc gtttaccact actacagtcg     1080

aatggccaac tatcggaaca cgagcgagat tcctctggtt ctggtgggaa cccaggatgc     1140

cataagttct gctaacccga gggtcatcga tgacgccagg gcgaggaagc tctccaacga     1200

cctgaaacgg tgcacgtact acgagacgtg tgctacatac gggctgaatg tggagagggt     1260

cttccaggac gttgcccaga agattgttgc cacaaggaag aagcagcagc tgtccatagg     1320

accctgcaag tcgctaccta attctcccag ccattcctcc gtctgttccg cgcaggtgtc     1380

tgccgtgcac atcagccaga caagtaatgg aggtgggagt ttaagcgact attcctcctc     1440

cgttccatcg actcccagca ccagccagaa ggaacttcgg atcgatgttc ctcccactgc     1500

caacacgccc acgcccgttc gcaagcagtc taagcgccgg tccaacctgt tcacctctcg     1560

gaaagggagc gacccagaca aagagaagaa aggcctggag agtcgtgcgg acagcattgg     1620

gagcggccga gccatcccaa ttaaacaggg cctgcccttc tttgtccttg cactgacagc     1680

cagcacttat ctcaggcctg ctggagcccg tgcccgtcag tcctccccct ggccagggcc     1740

gaggggtggt cagaccagcc cgcattgtgc tgaaggccca caatcagccc agctgtccgg     1800

ggccatgatg aattagcggt gggagttaac atagaggtga actccagatc ggccgatagc     1860

ttgcaggccg ctgctgtttg tcctgacttc agcgcatctc tgatagacct ttgacacctt     1920

ccaacaaaga ggttacagga gggagagctg gagaaatgga gcgctcctcc agaaagttcg     1980

gcaactcaca aaagacccct taatttctat agcgggcaat tcagtccaca aaggaaggaa     2040

atcaatgagc gtttacgctc tttctttgag gaaccttttt ttaaagaaaa aaacatttac     2100

tggcgctttg catgttttgg gtacaagcag tggtagaaac ataaaacatt aaaatccaag     2160

attga                                                                 2165


<210> 2668
<211> 1732
<212> DNA
<213> Homo sapiens

<400> 2668
attaaacaat atctggtctc ggtggctctg tcattccact gcaggcgtcc caccttcatt       60

tgccagctgg gatctcttaa tgagctagct gtgcacagtt caatagtaaa acccttttag      120

ctggtgaaat atgtttgaag aactcactgt tggagtgttc catgtgaggc ctgcttccac      180

tcttgctggc attctctttt caggatggct gcagctcctc caagttactg ttttgttgcc      240

ttccctccac gtgctaagga tggtctggtg gtatttggga aaaattcagc ccggcccaga      300

gatgaagtgc aagaggttgt gtatttctcg gctgctgatc acgaaccgga gagcaaggtt      360

gagtgcactt acatttcaat cgaccaagtt ccaaggacct atgccataat gataagcaga      420

cccgcctggc tctggggagc agaaatggga gccaatgaac atggagtgtg catagccaat      480

gaagccatca acaccagaga gccagctgcc gagatagaag ccttgctggg gatggatctg      540

gtcaggcttg gtttagaaag aggggaaaca gctaaagaag ccttagatgt cattgtctcc      600

ttgttggaag aacatggaca aggtgggaat tactttgaag atgcaaactc ctgccacagc      660

ttccaaagtg catatctgat tgtggatcgt gatgaagcct gggtgctcga gaccataggg      720

aagtactggg ctgccgagaa agtcacagag ggagtgaggt gcatttgcag tcagctttcg      780

ctcaccacta agatggatgc agagcatccg gaactcagga gttacgctca gagccaaggt      840

tggtggacgg gagagggcga gttcaatttt tccgaagtct tttctccagt tgaggatcat      900

ctagactgcg gtgctggcaa agacagctta gaaaaacaag aagaaagcat cacagtgcag      960

actatgatga acaccttacg ggacaaagcc agcggagtgt gcatagactc tgagtttttc     1020

ctcaccacag ccagtggagt gtctgtcctg ccgcagaata gaagctctcc gtgcattcac     1080

tacttcactg gaacccctga tccttccagg tccatattca agcctttcat ctttgttgat     1140

gacgtaaaac ttgtccccaa aacacagtct ccctgttttg gggatgacga ccctgccaaa     1200

aaggagcctc ggttccagga gaaaccagac cgccggcatg agctgtacaa agcccacgag     1260

tgggcacgtg ccatcatcga aagtgaccag gagcaaggtc gcaagctgag gagcaccatg     1320

ctggagctgg agaagcaagg cctggaagcc atggaagaaa tcctgaccag ctccgagcca     1380

ctggaccctg cggaagtggg ggaccttttc tatgactgtg ttgacacgga gattaagttc     1440

tttaagtgaa gtaagcgttc cctttcccct tcttatttaa gacttcccac cttactaaat     1500

taccagcaaa acaaaccact ctcctgtttg agtaaaatga gaaagttaat atgtggcctc     1560

cttttctgaa gccagatcaa actgttacct tgtgttccac cttgaatctc acagcgtccc     1620

cttctgcaat gtaggtctcc ttcctgtgca gtgtaacatg tatcccgttg cctgttgttc     1680

ggttgtgtga ctaattgtgg attttaagct gctattattg tatttcagtg gc             1732


<210> 2669
<211> 888
<212> DNA
<213> Homo sapiens

<400> 2669
ccaggcaggc ccagaagctg ggcagcctct gccgggttcc gggaaaagga gctcctgctg       60

ccactgctct tccggagcct gcagcatggg gcccctgccg cgcaccgtgg agctcttcta      120

tgacgtgctg tccccctact cctggctggg cttcgagatc ctgtgccggt atcagaatat      180

ctggaacatc aacctgcagt tgcggcccag cctcataaca gggatcatga aagacagtgg      240

aaacaagcct ccaggtctgc ttccccgcaa aggactatac atggcaaatg acttaaagct      300

cctgagacac catctccaga ttcccatcca cttccccaag gatttcttgt ctgtgatgct      360

tgaaaaagga agtttgtctg ccatgcgttt cctcaccgcc gtgaacttgg agcatccaga      420

gatgctggag aaagcgtccc gggagctgtg gatgcgcgtc tggtcaaggg ctgcagagaa      480

ggctggtatg tctgcagaac aagcccaggg acttctggaa aagatcgcaa cgccaaaggt      540

gaagaaccag ctcaaggaga ccactgaggc agcctgcaga tacggagcct ttgggctgcc      600

catcaccgtg gcccatgtgg atggccaaac ccacatgtta tttggctctg accggatgga      660

gctgctggcg cacctgctgg gagagaagtg gatgggccct atacctccag ccgtgaatgc      720

cagactttaa gattgcccgg aggaagcaaa ctcttcgtat aaaaaaagca ggccatctgc      780

ttaacccttg gctccaccat aaggcactgg gactcggatt tctctatctg atagaggtat      840

tttctgtggc cctgggagct gtctgtcttt cccctacccc caaggatg                   888


<210> 2670
<211> 4813
<212> DNA
<213> Homo sapiens

<400> 2670
agactaccgg cggcgacgac cacaggagca tggcggacac cgacctgttc atggaatgtg       60

aggaggagga gttggagcca tggcagaaaa tcagtgatgt cattgaggac tctgtagttg      120

aagattataa ttcagtggat aaaactacca cagtttctgt gagccagcag ccagtctcgg      180

ctccagtgcc catcgctgcc catgcttctg ttgctgggca cctctctaca tccaccaccg      240

ttagtagcag cggggcacag aacagcgaca gtacaaagaa gactcttgtc acactaattg      300

ccaacaacaa tgctggcaat cctttggtcc agcaaggtgg acagccactc atcctgaccc      360

agaatccagc cccaggtctg ggcacaatgg ttactcaacc agtattgagg cctgttcagg      420

tcatgcagaa tgccaatcat gtgactagtt cccctgtggc ctcacaacca atatttatca      480

ctacgcaggg atttcctgta aggaatgtcc ggcctgtaca aaatgcaatg aatcaggttg      540

ggattgtgct gaacgtacag caaggccaaa cggttagacc aattacacta gttccagccc      600

caggtaccca gtttgttaag ccgacagttg gagttccaca agtgttctcc cagatgaccc      660

ctgtgaggcc aggctccaca atgcctgtga ggcccaccac caacaccttc accaccgtca      720

tcccggccac tcttaccatt cgaagcaccg tcccacagtc ccagtcccag cagaccaagt      780

ccactcccag cacttctacc actcccactg ccacacagcc aacctcactg gggcaactag      840

ctgttcagtc tccaggccag tcaaaccaga ccacgaatcc caagctagtg agcattgcca      900

gctttgtcac tgtgaagcga cctggtgtta caggcgaaaa tagcaatgaa gtggccaaat      960

tggtgaatac ccttaacacc atcccttccc tgggccagag tcctgggcca gtggtggtgt     1020

ccaacaacag ctctgctcat ggctctcaaa gaaccagcgg acctgagtct tcaatgaaag     1080

tgacctcttc catcccagta tttgacctcc aggatggtgg acggaaaata tgtccacgat     1140

gtaatgctca atttcgtgtt actgaagctt tgagaggtca catgtgttac tgttgcccag     1200

aaatggttga ataccagaag aaaggaaagt ccctggattc agaacccagt gtcccatcag     1260

cagcaaagcc cccatcccct gagaaaacag ctcctgttgc ttccacaccc tcttctacac     1320

ctattcctgc tctgtcaccg cctaccaaag taccagaacc aaatgagaac gtgggcgatg     1380

ccgtccagac caaactcatt atgcttgtag atgacttcta ctatggacgg gatggtggca     1440

aagtagccca gctcacaaat ttccctaagg tcgccacatc tttccgatgc ccacattgta     1500

ccaaaaggct aaaaaacaat attcgattca tgaaccatat gaaacaccac gtagaactcg     1560

atcagcagaa cggtgaggta gatggtcaca ctatctgcca gcactgttac cgccagtttt     1620

ccactccctt ccagcttcag tgccacttgg aaaatgttca tagtccctat gaatctacta     1680

ccaagtgcaa gatctgtgaa tgggcgtttg aaagtgagcc actatttctc cagcatatga     1740

aggatactca taagcctgga gagatgcctt atgtttgcca ggtgtgtcaa tatcgctcct     1800

cactctactc tgaggtagat gtccattttc ggatgatcca tgaggatacc cggcatctgc     1860

tctgccctta ttgcctgaag gtcttcaaaa atggcaatgc attccaacag cattacatga     1920

ggcaccagaa gagaaatgtt tatcactgca acaaatgccg gctgcagttt ctctttgcca     1980

aggacaaaat tgaacacaag cttcaacacc ataaaacctt ccgtaaaccc aagcagctgg     2040

agggcttgaa accaggcacc aaggtgacaa tccgggcttc ccgagggcag ccacgaactg     2100

ttcctgtatc ctctaatgat acacctccca gcgccttgca ggaggcagca ccgctgacct     2160

cctcaatgga ccctctgcct gtcttccttt atccccctgt ccagcgcagc atccagaaga     2220

gagctgttag gaaaatgagt gtcatgggcc ggcagacatg cctggagtgc agcttcgaga     2280

tcccagactt ccctaatcat ttccctactt acgtacactg ctctctgtgt cgctatagca     2340

cctgctgttc tcgagcttat gccaaccaca tgatcaacaa tcatgttcca cggaagagcc     2400

ccaagtattt ggctttgttt aaaaattctg tgagtggaat caagctggcc tgcacttcat     2460

gtacctttgt tacctctgtg ggcgatgcta tggccaagca tttggtattc aacccctctc     2520

acagatccag cagcatcctg ccacggggac tcacttggat agctcactca aggcatggcc     2580

agactcgtga ccgagtgcat gaccggaacg tgaagaatat gtaccctcct ccttccttcc     2640

ccactaacaa agctgccact gtgaaatctg cgggggccac cccagctgag cctgaagagc     2700

tactaactcc cttagcccca gcactcccat caccagcctc aactgcaacc ccaccaccaa     2760

cccccactca cccgcaggct ttagcccttc caccgctggc tacagaggga gccgaatgtc     2820

tgaatgttga tgatcaggat gaagggagcc cagtcaccca agaacctgag ctagcatcag     2880

gtggtggtgg tagtggtgga gttggcaaaa aggagcagct gtctgtgaag aagcttcgag     2940

tagtactgtt tgctctatgc tgcaatacag aacaggcagc tgaacacttc cgaaatcccc     3000

agcgacgtat tcgccgttgg cttcgacgtt tccaggcctc ccagggggag aatctagagg     3060

gcaaatatct gagctttgag gcagaagaga aactggctga gtgggtgcta acccagcgcg     3120

aacaacagct acctgtaaat gaggagacct tgttccagaa ggccaccaaa ataggacgtt     3180

ctttggaagg ggggtttaag atctcctatg agtgggctgt gcgtttcatg ctgcggcacc     3240

acctgactcc ccatgcccgg cgagctgtgg cccacaccct acctaaggat gtagcagaga     3300

atgcaggact cttcattgat tttgtacaac ggcagattca caaccaggac ttacccttgt     3360

ctatgattgt ggctattgat gagatctctt tgttcctgga tacagaggtg ctgagcagtg     3420

atgatcgaaa ggagaatgcc ctgcagacag tgggcacagg ggaaccttgg tgtgatgtag     3480

tcctagccat tctggcagat ggcactgtcc ttcccaccct ggttttctac agagggcaga     3540

tggatcagcc tgctaacatg ccagactcca tattgctaga ggcaaaggag agtggctaca     3600

gtgatgacga gatcatggag ctgtggtcaa ctcgagtgtg gcagaagcac acagcttgcc     3660

agcgcagcaa aggcatgctt gtgatggact gtcatcgcac tcacttgtca gaagaggtac     3720

tggctatgct tagtgcctct agcactttgc ctgcagtggt cccagcaggc tgtagctcca     3780

aaattcagcc attagatgta tgcatcaaaa gaactgtcaa gaacttcctg cataaaaaat     3840

ggaaggaaca ggctcgggaa atggcagata ctgcatgtga ttctgatgtc ctgcttcagc     3900

tggtgcttgt ctggctgggt gaagtgctag gtgtcattgg ggactgtcca gagctagttc     3960

agcgctcctt cctggtggct agtgttctgc ctggccccga tggcaacatt aactcaccta     4020

caagaaatgc tgacatgcag gaggagctaa ttgcctccct agaggagcaa ctgaagctga     4080

gtggggaaca ttctgagtct tccactccac gacccagatc atctcctgaa gagacaattg     4140

agcctgaaag tcttcaccag ctctttgagg gtgaaagtga gaccgagtct ttctatggct     4200

ttgaagaagc tgacctagat ctgatggaga tttgagtgtt ggggtcatga gggggtgtgg     4260

agtgagggtg ggaacatgtg agggagggta aaggggctta gggaaaaggg ggcataccag     4320

gtggggtatt tggtttctat tttttaattt tataccacca ctcccccctg aagttgactt     4380

acacttccct gtggatttgt ggattaatta ggaaaaccaa tagtaatcac gtctgagcca     4440

aggagctggc ccattggtca ttcacttctg ctaaaaacag gtttttgtga cttttttttt     4500

ttttaaattt aaatcactgt gtttggtatt tttctgacaa aattaagaaa aagaaaaaaa     4560

attatttgtg ggcaaatgtt aaattttttt gtttcccctt ttacctcaat tgtatcatag     4620

tactgggttt ttttgtttgt tttattgtgt ggccaatgtc tttgggcatg atgctatcta     4680

atcattgtta atgtgagaac atttctgaag atgggaaaga caaattatgt agctcacaaa     4740

ctggtttatt atatatatgg ataaaaaact tttttcattg tggtcttaac acttttatat     4800

aaaaatgaaa atg                                                        4813


<210> 2671
<211> 1576
<212> DNA
<213> Homo sapiens

<400> 2671
acattttcaa ggaattcttg agaggttctt ggagagattc tgggagccaa acactccatt       60

gggatcctag ctggaatata aagaatggct tatcagtgga gaccatcgac agttgagaaa      120

agaagaagcc caaaaagtac aagaatgaaa atcgagagtt tttagagaac aacttgtaat      180

ggagccttca tctcttgagc tgccggctga cacagtgcag cgcattgcgg ctgaactcaa      240

atgccaccca acggatgaga gggtggctct ccacctagat gaggaagata agctgaggca      300

cttcagggag tgcttttata ttcccaaaat acaggatctg cctccagttg atttatcatt      360

agtgaataaa gatgaaaatg ccatctattt cttgggaaat tctcttggcc ttcaaccaaa      420

aatggttaaa acatatcttg aagaagaact agataagtgg gccaaaatag cagcctatgg      480

tcatgaagtg gggaagcgtc cttggattac aggagatgag agtattgtag gccttatgaa      540

ggacattgta ggagccaatg agaaagaaat agccctaatg aatgctttga ctgtaaattt      600

acatcttcta atgttatcat tttttaagcc tacgccaaaa cgatataaaa ttcttctaga      660

agccaaagcc ttcccttctg atcattatgc tattgagtca caactacaac ttcacggact      720

taacattgaa gaaagtatgc ggatgataaa gccaagagag ggggaagaaa ccttaagaat      780

agaggatatc cttgaagtaa ttgagaagga aggagactca attgcagtga tcctgttcag      840

tggggtgcat ttttacactg gacagcactt taatattcct gccatcacaa aagctggaca      900

agcgaagggt tgttatgttg gctttgatct agcacatgca gttggaaatg ttgaactcta      960

cttacatgac tggggagttg attttgcctg ctggtgttcc tacaagtatt taaatgcagg     1020

agcaggagga attgctggtg ccttcattca tgaaaagcat gcccatacga ttaaacctgc     1080

attagtggga tggtttggcc atgaactcag caccagattt aagatggata acaaactgca     1140

gttaatccct ggggtctgtg gattccgaat ttcaaatcct cccattttgt tggtctgttc     1200

cttgcatgct agtttagaga tctttaagca agcgacaatg aaggcattgc ggaaaaaatc     1260

tgttttgcta actggctatc tggaatacct gatcaagcat aactatggca aagataaagc     1320

agcaaccaag aaaccagttg tgaacataat tactccgtct catgtagagg agcgggggtg     1380

ccagctaaca ataacatttt ctgttccaaa caaagatgtt ttccaagaac tagaaaaaag     1440

aggagtggtt tgtgacaagc ggaatccaaa tggcattcga gtggctccag ttcctctcta     1500

taattctttc catgatgttt ataaatttac caatctgctc acttctatac ttgactctgc     1560

agaaacaaaa aattag                                                     1576


<210> 2672
<211> 6138
<212> DNA
<213> Homo sapiens

<400> 2672
gcgcgtttcc attttaaacc gccgcccgcc gcccgccacc cgccaccctt cggccgcagc       60

cggtgcagct gtccgcgcgt cccggagccc agggagtggc ggaggctgcg gaaccgccga      120

gctgtgcagc cggagcggga ggatgcgcac gggccccgcg tcgtagacaa tgaagccgcg      180

ggcgccgccg cctgccctgg gccctgcgca ccgcggccgc acctgccggc gagagcgctc      240

tagcgcctga ccggccgcct cgcttggccc cgccggccca tggctcggcg ccccgggccc      300

ggaccccggc actcgggcgg cgcggcgcac gggccggcgg gtgccagggg cgccgtcccc      360

gcagcctgag tgcggccctc gcggtcagcg gggggcgtgg gccacactcc cggcccgcct      420

gccctccccg cttggcccgg cgccctcccg gcccgcgggc tcgctggatg cggcggggcc      480

ccagcgcgcg ggcgacatgt acttgttgga cggcagtggc gagcccgcgt cgccacccgc      540

ggacgcgatg ccgcgcggga cgccccccag aaagactgtc taccgcatct ccgtgaccat      600

ggtcaggaag gagcagctgg ccgcgccggg ctccggcggc ccggacccac gcccggttcg      660

gcggccccgg cccgcgcgct ccccggacgc gcccgggagg cttgaggagg aggccgagga      720

ggcggagggc gccgaggaac cggagggtcc ccggccgcgc gcttgggatt tccgcacctt      780

ccgcacccgc agcaccgggc agctggaact ggggcggctc cggccgtgcg cacgcggcct      840

ggaacccgcg gacctggccg gcagcgcccc ggccgaggag gagggacgcg gctcgcccgc      900

gtccggcagc cccgacgtgg agggggcccg ggccgcgccc ctgcggcgga gcctgagctt      960

caggcactgg agcgggcctg aggcgccgca aggccggaca ctgggcggcg gaaggcgcca     1020

cagcagctcc gggagcctgg cctgggcgcc gtgcgacgag gccgcggccg ggaccaccct     1080

ggagcccgcg accgccacgc agcccgcctc ggagaagcgc aacaccctgg acgtgggcga     1140

ggtgctcagc aagaacgacg cgctctcgga cctggagcgt tgggaacgca gtaagagcaa     1200

gaaccgcacg ctggacaaca gcgacctgca gcggctggag cgcgcgcggg cggcggccgg     1260

ggccggcgcg gcctcggagc accggctgct gcgcttcttc agcggcatct tcgcgcgcag     1320

ggacgggggc ccgggcggcg ggccctcgcc acggagcgga gcctcgcggc cacgcggcta     1380

cttcagcctg cggcgggccc cggccgaagc gcactcgtcc agcgccgaga gcatcgacgg     1440

ctccccgcgc agagatgcct tcgtgaacag ccaggaatgg acgctgagtc gatctgtccc     1500

ggagctcaaa gtgggaattg tgggtaactt ggccagcggc aagtctgccc tggtgcaccg     1560

gtacctgacg ggcacatatg tccaggagga gtctccggaa ggtggcaggt tcaagaaaga     1620

gattgtcgtt gatggacaga gctatctgct gctgatcaga gatgaagggg gccccccgga     1680

ggcgcagttt gccatgtggg tggacgctgt tatatttgtc ttcagcttgg aggatgaaat     1740

aagtttccag accgtttacc actactacag tcgaatggcc aactatcgga acacgagcga     1800

gattcctctg gttctggtgg gaacccagga tgccataagt tctgctaacc cgagggtcat     1860

cgatgacgcc agggcgagga agctctccaa cgacctgaaa cggtgcacgt actacgagac     1920

gtgtgctaca tacgggctga atgtggagag ggtcttccag gacgttgccc agaagattgt     1980

tgccacaagg aagaagcagc agctgtccat aggaccctgc aagtcgctac ctaattctcc     2040

cagccattcc tccgtctgtt ccgcgcaggt gtctgccgtg cacatcagcc agacaagtaa     2100

tggaggtggg agtttaagcg actattcctc ctccgttcca tcgactccca gcaccagcca     2160

gaaggaactt cggatcgatg ttcctcccac tgccaacacg cccacgcccg ttcgcaagca     2220

gtctaagcgc cggtccaacc tgttcacctc tcggaaaggg agcgacccag acaaagagaa     2280

gaaaggcctg gagagtcgtg cggacagcat tgggagcggc cgagccatcc caattaaaca     2340

gggcatgctg ttgaagcgaa gtggcaaatc gttgaataaa gagtggaaaa agaaatatgt     2400

caccctgtgt gacaatggcg tgctgaccta tcatcccagt ttacatgatt acatgcagaa     2460

tgttcatggt aaggagattg accttctgag aaccactgtg aaagtcccag ggaagaggcc     2520

accccgagcc acgtcagcct gcgcacccat ctccagccct aaaaccaatg gcctatccaa     2580

ggacatgagc agtttacaca tctcacccaa ttcagacaca gggctgggtg actccgtatg     2640

ctccagcccc agtatctcca gcaccaccag ccccaagctc gacccgcccc cctcccctca     2700

cgccaacaga aagaagcacc gaaggaagaa aagcactagc aacttcaaag ccgacggcct     2760

gtccggcact gctgaagaac aagaagaaaa ttttgagttt atcattgtgt ccctcactgg     2820

ccaaacatgg cactttgaag ccacgacgta tgaggagcgg gacgcctggg tccaagccat     2880

cgagagccag atcctggcca gcctgcagtc gtgcgagagc agcaagaaca agtcccggct     2940

gacgagccag agcgaggcca tggccctgca gtcgatccgg aacatgcgcg ggaactccca     3000

ctgtgtggac tgcgagaccc agaatcccaa ctgggccagt ttgaacttgg gagccctcat     3060

gtgcatcgaa tgctcaggga tccaccggaa tcttggcacc cacctttccc gagtccgatc     3120

tctggacctg gatgactggc cagtcgagct catcaaggtg atgtcatcca tcgggaacga     3180

gctagccaac agcgtctggg aagagagcag ccaggggcgg acgaaaccat cggtagactc     3240

cacaagggaa gagaaggaac ggtggatccg tgccaagtac gagcagaagc tcttcctggc     3300

cccgctgccc tgcacggagc tgtccctggg ccagcacctg ctgcgggcca ccgccgacga     3360

ggacctgcgg acggccatcc tgctgctggc acacggctcc cgggacgagg tgaacgagac     3420

ctgcggggag ggagacggcc gcacggcgct gcatctggcc tgccgcaagg ggaatgtggt     3480

cctggcgcag ctcctgatct ggtacggagt ggacgtcacg gcccgagatg cccacgggaa     3540

cacagctctg gcctacgccc ggcaggcctc cagccaggag tgcatcgacg tgctgctgca     3600

gtacggctgc cccgacgagc gcttcgtgct catggccacc cctaacctgt ccaggagaaa     3660

caataaccgg aacaacagca gtgggagggt gcccaccatc atctgaggaa cagccgtgcc     3720

cgcctgctcg ccgcacctgg gacgcggcag cctcgccgca ttctcgctca gaagtcgcag     3780

cacgtgagtc ccgtcgcatc ccctccctct tcctggtggc cacctccctc ccgcccaccc     3840

actctcaccc caaacaaaat cacaaaacct ggacatccct caaggggcga agaggcggcc     3900

gggagactgc agaagtggct ccttttcata aactccccta aaccacacac aggagagagc     3960

gacgggcctc ggccctttga tgatagcaca tggcgcagga cccttgtcct ggtggcacaa     4020

gggatgggga cgcgaggggg aggggaggcg aggaacaagg agaaggggca actttcctta     4080

actggcagtt gagcacatag tacatttccc ctctaccaaa cggaacactt ggattccatc     4140

tcttctctga ggagctcgac ggcataaatc agaagcaagc acagagtttg tcaggtttga     4200

agcccctatg atggtgtgtg tcaaatcagt tgtagctaat ctgtccaggg agaatactgg     4260

cttcattaca cttgtacagc cgagttcttc ccgcattact gctgtttaat agaacgtgat     4320

tagtcatcgc cgagaagaaa gcatattagc cgaggaggta gtcacgcggc acgcgccggt     4380

gattgccacg atgtgattgc aatactctta gaagcaccat attatcccag acatgttctt     4440

tcaagccctt ggagccctct ctaaattcac tgtcatcatt tagtatctgt ttaatttttc     4500

agtccaaaga gaggaaatca gtcgctgagt attatttgac tccggtctcc ttggtgcaaa     4560

aacaaaatgg gaaaaataaa taagaataac tcagaaactc aaaaggaaac cacaaattca     4620

gctaataata gcatttcgag tatatttcgt aaactaagga aatacacaaa aggctgtttt     4680

ttccgactgt aagagatatt tgatgtcctt ttgccgaggt ggatgtgtta gtctcaggcc     4740

ctcctggacc acgttgccca agtcacacag gcttctgtgt tatgtattta gataagatgt     4800

gtgaaaatat atttgaataa aagaagttca taaatatgca ttgatttttg tacagacaaa     4860

tggcacctct cttaatttat aaattgaact ggatgtgaac taataatgtg caactagttg     4920

agataagagg gttacagatc attgtacatg gaaaatattc ccagcagtaa acacttccat     4980

taatgtgatc tacggctttt gaaaaggagc atctcagaat aagatggtgg tacaatttgc     5040

ttattaaaat tgagaaagaa aaaaaaagac acactggagt atattagaaa ggaaaaagaa     5100

ggaatgtggt ctctcatgat tgaaagcatg atttagatcg gatacggctt ttgctaacca     5160

aggaccaagg gactctggca agatggggtg gttttccgaa tgccagaccg aggtgcctta     5220

cgaaggcagc tgccaatggt tctgtggcac agactggctc ctgagaaccc agacgacctt     5280

gacctggcag cccggccctc cacgctagta cctcgcctga ttttccatcg ttgcggtatc     5340

cagccgcttc agacgtccgc cgccttcagt ggtggtagtc aaatgtagtc aaccaaacca     5400

cagcatccct taggttaaaa gcaaacgggg cagctttgcc tagagctcat tgacagtgtg     5460

atggggggag aagggttgtc acaatggaag atgaggacac tagactcatg tagcacagaa     5520

acatgaagcc acacgcaccg gcagcctccg gggtgttcct cgctctctcg tatgttaaac     5580

cttatatttt ataagagttt ttcctcttat ttcacttttt aaaaaaaatt aaagtaggtg     5640

gggaaaaaaa taaagcttta cacagaattt atatgtgggt aagtgtttca tggaaatttc     5700

taatcttaac gaagctaagt ggagctcact cgtatccaaa agtataacag gtgcagaagc     5760

cacaagtctg agaaccttga cgacagttcc atcgtcctgc catttgattt ttcagtctgc     5820

gtttcatcac tgtgtagcta ttgtaaatgt gaatagaaaa aaacaggtca ttgcctattt     5880

ttgaagaacg cgttggtgtt cgagtccact agacacactc gctccacaca gccttcaccg     5940

tagactctgt agtggacaca gatatagcat aaatgaaatt gttaaattat ttcattgtag     6000

ttaattccca ctataggaat gctttatcat agtgaagttt cttttgagaa gaaacggaac     6060

tccttgaggc ttctctttgg gatgtatatg agcgtgtaca tattattcta tgtgtttata     6120

atataatatt ttcccaaa                                                   6138


<210> 2673
<211> 3383
<212> DNA
<213> Homo sapiens

<400> 2673
gacttccggt gctggaggag ggggccggcg gcgagggact ccaggaggac gcgtccaact       60

tcgagaccgg cgggggccgg ctccgctctt ccaacccctc catgtgtgaa gagggcggac      120

gacgcagcgg gggaagaaaa ataagctagt ctaggacaag tgtccaggcg acgtggaacc      180

cagtaaggga ataaagaaga ctggaaacgt ctctcccctc ccctatccca gtccctcacc      240

ctaatccgcg cgcaatagaa aaggcggaag cgcctgtcca cgatcagggc ggggcaaggg      300

gaagaaatct cgcgatagga gagcggtccg ggcgggggtg gcacctctcc ctcctcctgg      360

cgttagttcc ggtcgcagag gagacaccgc cgcagttgcc ggtacatcgg ggatttctgg      420

ctctttcctc ttcgccttaa attcgggtgt cttttatgaa taatcaaaag cagcaaaagc      480

caacgctatc aggccagcgt tttaaaacta gaaaaagaga tgaaaaagag aggtttgacc      540

ctactcagtt tcaagactgt attattcaag gcttaactga aaccggtact gatttggaag      600

cagtagctaa gtttcttgat gcttctggag caaaacttga ttaccgtcga tatgcagaaa      660

cactctttga cattctggtg gctggtggaa tgctggcccc aggtggtaca ctggcagatg      720

acatgatgcg tacagatgtc tgcgtgtttg cagcccaaga agatctagag accatgcaag      780

catttgctca ggtttttaac aagttaatca ggcgctacaa atacctggag aaaggttttg      840

aagatgaagt aaaaaagctg ctgctgttct tgaagggttt ttcagagtcg gagaggaaca      900

agctagctat gttgactggt gttcttctgg ctaatggaac acttaatgca tccattctta      960

atagccttta taatgaaaat ttggttaaag aaggagtttc agcagctttt gctgtgaagc     1020

tctttaaatc atggataaat gaaaaagata tcaatgcagt agctgcaagt cttcggaaag     1080

tcagcatgga taacagactg atggaactct ttcctgccaa taagcaaagt gttgaacact     1140

tcacaaaata ttttactgag gcaggcttga aagagctttc agaatatgtt cggaatcagc     1200

aaaccatcgg agctcgtaag gagctccaga aagaacttca agaacagatg tcccgtggtg     1260

atccatttaa ggatataatt ttatatgtca aggaggagat gaaaaaaaac aacatcccag     1320

agccagttgt catcggaata gtctggtcaa gtgtaatgag cactgtggaa tggaacaaaa     1380

aagaggagct tgtagcagag caagccatca agcacttgaa gcaatacagc cctctacttg     1440

ctgcctttac tactcaaggt cagtctgagc tgactctgtt actgaagatt caggagtatt     1500

gctatgacaa cattcatttc atgaaagcct tccagaaaat agtggtgctt ttttataaag     1560

ctgaagtcct gagcgaggag cccattttga agtggtataa agatgcacat gttgcaaagg     1620

ggaagagtgt tttccttgag caaatgaaaa agtttgtaga atggctcaaa aatgctgaag     1680

aagaatctga atctgaagct gaagaaggtg actgaatttt gaaactacac cctcagtaaa     1740

gcaaacagga gttgtagata aaatgtcatg tctcatgtgt cctggttctt acatcttcct     1800

acctccctgt atcaagcatg atataagggc tttcatggca aattttattt taactgtttc     1860

tatggttgct ggaaatgttg ggtttagttt ctaaaaccat gttttaagta gctacaggag     1920

ctatagattt gaatctaatg ttgcattagt cttttcagtt atcttctacc tcctgtattt     1980

tctactgtaa taatgtaatt taaggccttc cacaatgaac agttcacttt attccctggg     2040

ttttctataa acagttttaa ggatatgatt tggttaaaaa ataatttgtt ataaaaattc     2100

tgtttgcaaa ttaaactgga aaagtatcca gagtctcaaa aggcaatgat ttgtgagata     2160

atatggcatg cccggagccc tgctcatcaa tgaaaaaccc atatgtaata atcgaattca     2220

tttaacatga atcttgagta cgtggaccat tgcttgcatg ttaacttttt gttttgtttt     2280

gttttgtttt gttttgcatt tttaactcca gatatcctaa agctcaattg tttggtctct     2340

ggttttcatc cttagagaag ccatggagaa cagacttgaa aagtttagga aatcataatg     2400

tggcagaggt ggtgggaaga agaaagttga gctttttccc cttgagaaac ttctgcattt     2460

agtttctatc tttccaggca aaacaaatgg gtattctttt catacaacca ttttcaaatg     2520

aaccttagaa aagtcttaac atttaaggta ttttatgcac agaatacact tagattgata     2580

ggaaagaact cgtaatggag tttgagtaaa gaaaatgact gatgtactaa acccagtaaa     2640

aattgttgaa aatgttaaag gtcagcatgt tctaattggg aatctagata tagcttagat     2700

ttcctattgg cttagagtat ttgctataac aaatgaagtg caatgacaat tatatattcc     2760

tactcggtca tactggactg gcttcgttct cttaatatac tcagtaatga ctcaagcctc     2820

tggctattaa cataccctag ttgccgtttt ttaattgcca tgagccaaat acttcttggt     2880

atacaattga tccatttatt ttaatggctg ccttttcatt ttcatctttt cttgctgcta     2940

cccatctatg tatgtagtca ttggggggaa aatgtagcca cattttttat gggaagactt     3000

tgtgttaaaa gtgaacattt tgaaggtttt taactggtga aactagcctg gaataatgcc     3060

accagagact gagtggaaat cgcccctttt gaaggtgcca ttcttatgag ccaaaagttt     3120

gtcatttaaa agttcatttt gagggaataa catgtaatat aatttgaaat aaaggtatag     3180

taaccttaaa aagaacatta taactgattg ttgtgaatgg ggtgaatttg ttaaaatgag     3240

taactttgat aaagtttttc atgcacaggc aaaatgtatt cactagattt ctacgtagtg     3300

atctgctttt actttgtaat ttgtagttct caaaagactt ttttttaaaa aaataaagtc     3360

catacttaca cttaggcttt ata                                             3383


<210> 2674
<211> 2901
<212> DNA
<213> Homo sapiens

<400> 2674
tgaggaggcg actgactgag cagcgcaccc ggggagcaag gaggcgcggt gaactgagcg       60

gcccctgagc tgacagatac actgcgcagc tggaacggcg agcgagccga cgggcgagtg      120

aggggcgcag ccatgatcac ctcggccgct ggaattattt ctcttctgga tgaagatgaa      180

ccacagctta aggaatttgc actacacaaa ttgaatgcag ttgttaatga cttctgggca      240

gaaatttccg agtccgtaga caaaatagag gttttatacg aagatgaagg tttccggagt      300

cggcagtttg cagccttagt ggcatctaaa gtattttatc acctgggggc ttttgaggag      360

tctctgaatt atgctcttgg agcaggggac ctcttcaatg tcaatgataa ctctgaatat      420

gtggaaacta ttatagcaaa atgcattgat cactacacca aacaatgtgt ggaaaatgca      480

gatttgcctg aaggagaaaa aaaaccaatt gaccagagat tggaaggcat cgtaaataaa      540

atgttccagc gatgtctaga tgatcacaag tataaacagg ctattggcat tgctctggag      600

acacgaagac tggacgtctt tgaaaagacc atactggagt cgaatgatgt cccaggaatg      660

ttagcttata gccttaagct ctgcatgtct ttaatgcaga ataaacagtt tcggaataaa      720

gtactaagag ttctagttaa aatctacatg aacttggaga aacctgattt catcaatgtt      780

tgtcagtgct taattttctt agatgatcct caggctgtga gtgatatctt agagaaactg      840

gtaaaggaag acaacctcct gatggcatat cagatttgtt ttgatttgta tgaaagtgct      900

agccagcagt ttttgtcatc tgtaatccag aatcttcgaa ctgttggcac ccctattgct      960

tctgtgcctg gatccactaa tacgggtact gttccgggat cagagaaaga cagtgactcg     1020

atggaaacag aagaaaagac aagcagtgca tttgtaggaa agacaccaga agccagtcca     1080

gagcctaagg accagacttt gaaaatgatt aaaattttaa gtggtgaaat ggctattgag     1140

ttacatctgc agttcttaat acgaaacaat aatacagacc tcatgattct aaaaaacaca     1200

aaggatgcag tacggaattc tgtatgtcat actgcaaccg ttatagcaaa ctcttttatg     1260

cactgtggga caaccagtga ccagtttctt agagataatt tggaatggtt agccagagcc     1320

actaactggg caaaatttac tgctacagcc agtttgggtg taattcataa gggtcatgaa     1380

aaagaagcat tacagttaat ggcaacatac cttcccaagg atacttctcc aggatcagcc     1440

tatcaggaag gtggaggtct ctatgcacta ggtcttattc atgccaatca tggtggtgat     1500

ataattgact atctgcttaa tcagcttaag aacgccagca atgatatcgt tagacacggt     1560

ggcagtctgg gccttggttt ggcagccatg ggaactgcac gtcaagatgt ttatgatttg     1620

ctaaaaacaa acctttatca ggatgatgca gtaacagggg aagcagctgg cctggcccta     1680

ggtttggtta tgttgggctc taaaaatgct caggctattg aggacatggt tggttatgca     1740

caagaaactc aacatgagaa gattctgcgt ggtcttgcag ttggcatagc tttagtaatg     1800

tatgggagga tggaagaggc tgatgctctc attgaatctc tctgtcgtga caaggaccca     1860

attcttcgaa ggtctggaat gtatactgta gccatggctt attgtggctc tggtaacaac     1920

aaagcaattc gacgcctgct acatgttgct gtaagtgatg ttaatgatga tgtcaggagg     1980

gcagcagtag aatcacttgg gttcattcta ttcagaaccc ctgaacagtg cccaagtgtt     2040

gtctctttgt tgtcagagag ttacaaccct catgtgcgct acggagctgc aatggccttg     2100

gggatatgct gtgctggtac aggaaacaag gaagccatta atttgctaga accaatgaca     2160

aacgaccccg tgaactacgt gaggcaaggg gcactcatag cttcagctct catcatgatc     2220

cagcagactg aaatcacttg tccaaaggtg aatcagttca gacagctgta ttccaaagtc     2280

atcaatgata agcatgatga tgtcatggcc aagtttggcg ctattctggc ccagggcata     2340

ctggatgcag gtggtcataa tgtcacaatc tccttgcagt ccaggactgg gcatactcat     2400

atgccttctg tggttggcgt ccttgtattt acccagtttt ggttctggtt tcctctttca     2460

cacttcctgt cattggctta tacccctacc tgtgtcattg gccttaacaa ggacttaaag     2520

gtttctactg ctgtattatc tataactgcc aaggctaaaa agaaggaaaa agaaaaggaa     2580

aaaaaggagg aggagaaaat ggaagtggat gaggcagaga aaaaggagga aaaagagaag     2640

aaaaaagaac ctgagccaaa cttccagtta ttggataacc cagcccgagt tatgcctgcc     2700

cagcttaagg tcctaaccat gccggagacc tgtagatacc agcctttcaa accactctct     2760

attggaggca tcatcattct gaaggatacc agtgaagaca ttgaggagct ggtggaacct     2820

gtggcagcac atggcccaaa aatcgaggag gaggaacaag agccagaacc cccagaacca     2880

tttgagtata ttgatgatta a                                               2901


<210> 2675
<211> 770
<212> DNA
<213> Homo sapiens

<400> 2675
ctttccaact tggacgctgc agaatggctc ccgcaaagaa gggtggcgag aagaaaaagg       60

gccgttctgc catcaacgaa gtggtaaccc gagaatacac catcaacatt cacaagcgca      120

tccatggagt gggcttcaag aagcgtgcac ctcgggcact caaagagatt cggaaatttg      180

ccatgaagga gatgggaact ccagatgtgc gcattgacac caggctcaac aaagctgtct      240

gggccaaagg aataaggaat gtgccatacc gaatccgtgt gcggctgtcc agaaaacgta      300

atgaggatga agattcacca aataagctat atactttggt tacctatgta cctgttacca      360

ctttcaaaaa ttgtcaccat cagtgagaaa ccgaacaaga agaggaaagc aaatggcatt      420

ttcttctcta cttggtgaaa agtcattata gaggattcga acggttccaa tgctcgcaat      480

tctacttcaa gcatgtgctc attctacata tcaacccctt tttcactgac aaatgtaatg      540

ttgacaatct aggctaatgg gactagattt tgaatccaat caacactttt tcatataaag      600

ttttcagaat aacaaagctt tccctcattc atacagatat tgctgtacta atctataatt      660

atgttttaga attcaaatta taacactgac taaacatcac taatgaaaca tttgtgacct      720

ccttttttcc gaagtttaat ttttgctttg aattcatatt ttatcagtat                 770


<210> 2676
<211> 1058
<212> DNA
<213> Homo sapiens

<400> 2676
tcgcggcggt ggctttgtgc cacttttccc agggcttggg catcattctg gacccatgtt       60

cggtgaaccg gttactctca gagctgcttt cgggcgcagc tcctgctgca gccagggccc      120

gttttaagag aggcttccag gtccagccct cccgctgcag cctgcaggga gcgagccggc      180

ctgtcccgat gacatagaca ctaggttttt acagcaattc tctgatgacc ttgatatggt      240

agaacgctgt gtatttcaag agtaagctct cgtttgagga gactaacaat tcctgttttc      300

gccagtgcca cctgtgatat atgtgaagtt cctgaaatac ctaagtccaa gttacagctc      360

tgtcatattc tactgattat ttgttcctgt acctgtacaa gatttcttct tgaatggcaa      420

cctaaatgcc agtccaaaga ggcccccaat agacttgttc acccttcatg tcctcaactc      480

tggggaagtt aagtaatcaa gttgaagaaa cacttccact acttaaaaag gtacctgcaa      540

attactttca catttgttca gctatcctaa tgggattttc acttagtaaa tctgctactc      600

aggtatctgc tatacatatg gattcaaaag tggatgatca cttaatacga gggactgaaa      660

aaagcaggtt ggaaccagcg actcagttat ttcaaaacac caagaaaata agattagaag      720

acacaaatca agaaaacttt acaaggattg aagggactgg cacaggatct ctttctggga      780

aagccttggg ttcagtggta tatgtcaaag aaagtgatgg actagaaatg acagatgtgg      840

aatgaagcaa tttgtacgta ttaccaaaga aaccaaaaac tgcctttgac taaggggggt      900

gttgaaagag aacttaacct tattaggaaa ccctgacaaa atgatggaag actattgcct      960

tattttgcac tatttgtgaa tcatcttaca ctgcattttt ttatgatgct tattcaaaag     1020

gcagttgctt tagggtgaaa aagccttcca agattcaa                             1058


<210> 2677
<211> 1500
<212> DNA
<213> Homo sapiens

<400> 2677
atgtctactc cttctggaat atccacctgg ctcagcctgc ctgtttcgac tcctgcctcc       60

atcacatcca tcagagtgac ccagaagtcc tctggcccct gggccttcag cagctgcacc      120

tacgtgagtg ggcctggcgt ctgcatcagc tccttgagct gctcccgagt ggggagcagc      180

agctttcggg gtggcctggg tggaggctat ggtggggcca gtggcatggg aggcatcatc      240

gccatcatgg tcaaccagag cctgttgagc ccccttaacc tggaggtgga ccccaacatc      300

caggccgtgt gtacccagga gaaggagcag atcaagaccc tcaacaacaa gtttgcctcc      360

ttcatcgaca aggtatggtt cctggagcag cagaacaagg tgctggagac caagtggagc      420

ctcctgcagc agcagaagat ggctcggagt aacatggaca acatgttgga gagctacatc      480

aacaacctta ggcggcagct ggagactctg ggccaggaga agctgaagct ggaagcagag      540

cttggcaaca tgcaggggct gggggaggac ttcaagaaca agtatgagga tgagatcaat      600

aagcatacgg aggtggagaa tgaatttgtc ctcatcaaga aggatgttga tgaagcttac      660

atgaacaagg cagaactgga gtccctcctg gaagggctga ctgacgagat caacttcctc      720

aggcagctgt atgaagagga gatccgggag ctgcagtccc agatctccga catgtctatg      780

gtgctgtcca tggactacag ctgctctcgg gacatggaca gcatcatccc tgaggtcaag      840

gtgcagtatg aggagattgc caactgcagc cgggctgagg ctgagagcat gtaccagatc      900

aagtatgagg agctgcagac gctggctggg aagtacgggg atgacctaag ccgcacaaag      960

actgagatct ccgagatgaa ccggaacatc agctggctcc aggctgagac cgagggcctc     1020

aaaggccaga gggcttccct ggaggccgcc atcacagatg ccgagcagcg tggggagctg     1080

gctgttaagg atgccaacgc caagctgtcc gagctggagg ccgccctgca gcgggccaag     1140

caggacatga tggggcagct gcgtgagtac caggagctga tgaacgtcgg gcttaccctg     1200

gacatcgaga ttgccaccta caggaagctg ctggagggcg aggagagccg gctggaatct     1260

gggatgcaga acgtgagtat ccatacgaag accaccagca gctatgcagg tgggctgagc     1320

tcggcctatg ggggcctcac aagccccggc atcatctacc gcctgggctc cagctttggc     1380

tctgccgcgg gctccagctc cttcagccgc accagctcca ccagggccgt ggttgtgagg     1440

aagatcgaga cccatgatgg caagctggag tccgagtcct ctgacgtcct gtccaagtga     1500


<210> 2678
<211> 2201
<212> DNA
<213> Homo sapiens

<400> 2678
gggcgggcga ggagctgcgc acgcgcgggg acgcgcgccc ggcctgtcgc tgtggaaacc       60

gctaggccag cgctcgccgg gacctggaat ccctgtacgc cgaggtggga gccggtggac      120

cggtccccca gccggccccc acctccgctt cccggtgttt gagggttcgg gcctcccgcc      180

ggggagttca cccctcgggc tcgtcagtag ggctgtggct gtcgcctctt cctgcagcgc      240

caggctccgc ccggtctcac agtcggctta ggggctttgc gtgcactgcg gttgggtgga      300

aaaacccact cctggttgtt tagacgttgg cctgcagacg atgtcatttc tgtattcctc      360

taaggcagga agtcattatg caacttacac atattcatca gatttcctct gacttacccg      420

gacatgtaca tgggaatgat gtgcactgcc aagaaatgtg ggattaggtt tcagcctcca      480

gctattatct taatctatga gagtgaaatc aaggggaaaa ttcgccagcg cattatgcca      540

gttcgaaact tttcaaagtt ttcagattgc accagagctg ctgaacaatt aaagaataat      600

ccgcgacaca agagttacct agaacaagta tccctgaggc agctagagaa gctattcagt      660

tttttacgag gttacttgtc ggggcagagt ctggcagaaa caatggaaca aattcaacgg      720

gaaacaacca ttgatcctga ggaagacctg aacaaactag atgacaagga gcttgccaaa      780

agaaagagca tcatggatga actttttgag aaaaatcaga agaagaagga tgatccaaat      840

tttgtttatg acattgaggt tgaatttcca caggacgatc aactgcagtc ctgtggctgg      900

gacacagagt cagctgatga gttctgatac caaacactca aaacatgcat tgggctagca      960

gaatatccat gtttattacc agactggttc tggaagaagc tgtaaagaat actaaatatg     1020

ttgggttata ggggattgac catgttactt ttcaaaacca ggacatttaa agcatctact     1080

atgtaggtgc atgaggagta tgggaaaaac agaataaagg aatctgcctt taaggagctt     1140

acaatcatgc cgggtgcggt ggctcacgcc tgtaatccca gcactttggg aggctgaggc     1200

gggtggatca cctaaggtca ggagttcgag accagcctag ccaacatggt gaaacctcgc     1260

ctctactaaa aatacaaaaa ttagccaggc gtggtggcgg gtgcctgtaa tcccggctac     1320

tcaggaggct gaggcaggag attcgcttga acctgggagg ctgaggttgc agtgagccga     1380

gatcgcgcca ttgtactcca gcctgggcga tgagcaaaac tccatctcaa aaaaaaaaaa     1440

aaaaaaaagc ttacaatctg actggaagat gtcaaaacct gtgaaaagct aattagcagt     1500

attaagcaac acaaacatta gtgccaaatg catgataaag gctaaagaag gccagagcat     1560

atattactgt agagtagaat agtaagggaa gactttgtcc tttagtaaag agataggagg     1620

tggcctggcc cttgaaatag tagtgtttag gtagatgctt gtgtaggatt cctgataaga     1680

gcaactgaaa agaaggagag gggaagtagt aaagggacaa gaaacaattt tttttttgag     1740

gaaccataag caaattatag tttgacaaga caagattggg ggacatatat ggttaccagg     1800

gaattacctc ttatgtgtta tatctttata ttatttatct ctggaaaaga gtaccctgca     1860

aaattcccta cagctgcaag cagatgtcac ttgatggaca gagggggaat tctgcccctc     1920

cggtatcggg aaatacatac taaagacatt gcgaaacgct gaacctcttc ccataaataa     1980

aaggtttgtt tgtaaaatgg gaaatccacc cataataaat gaacaatagg cactgccagt     2040

ttaggcctgt tcatgaatgg atctgcaaga cagcatcttc gtttaacaac attatctgtg     2100

atttgataca tttatcctta ttacaatatt gtttagttgg tagaaattct atgttttcta     2160

caaggaaatt gatgtttatt aaataaaact gaaaataatt a                         2201


<210> 2679
<211> 825
<212> DNA
<213> Homo sapiens

<400> 2679
ctttccaact tggacgctgc agagtgagta tgggtggcgg agtctgggct cctggaatcc       60

agccccatcc tcctttggga ttgtgctaac tgggaccgca aaatctctcc cgagccagcc      120

cggggctccg gttgtgggga gatgggaata caccctgctt ttaaaggctc ccagagcctg      180

aggaagaaag tgaccaggct taggggagcc ggagcggcag ggatttccgg gtcggaggca      240

tctgaggggc gcaggggcgc gggtgcgtgg gccactgggt gaccgactta gcctggccag      300

actctcagca cctggaagcg ccccgagagt gacagcgtga ggctgggagg gaggacttgg      360

cttgagcttg ttaaactctg ctctgagcct ccttgtcgcc tgcatttaga tggctcccgc      420

aaagaagggt ggcgagaaga aaaagggccg ttctgccatc aacgaagtgg taacccgaga      480

atacaccatc aacattcaca agcgcatcca tggagtgggc ttcaagaagc gtgcacctcg      540

ggcactcaaa gagattcgga aatttgccat gaaggagatg ggaactccag atgtgcgcat      600

tgacaccagg ctcaacaaag ctgtctgggc caaaggaata aggaatgtgc cataccgaat      660

ccgtgtgcgg ctgtccagaa aacgtaatga ggatgaagat tcaccaaata agctatatac      720

tttggttacc tatgtacctg ttaccacttt caaaaatcta cagacagtca atgtggatga      780

gaactaatcg ctgatcgtca gatcaaataa agttataaaa ttgcc                      825


<210> 2680
<211> 3000
<212> DNA
<213> Homo sapiens

<400> 2680
agtggcagtc aggcctcccc gctctgtgct acctgcggcc cggctctcct ccgcgccccc       60

actcgcgctg cgatgacgcg ctcactgttc aagggaaact tttggagtgc agacatcctc      120

agcaccatcg gctatgacaa cattatccaa catctgaaca atggccgcaa gaactgcaaa      180

gagtttgaag actttctaaa agaaagggca gcaattgaag agaggtatgg caaagatctg      240

ctcaacctct ctaggaagaa gccgtgtgga cagtctgaaa tcaacaccct gaagcgggcc      300

cttgaagtct tcaagcagca agtagacaat gtggcacaat gtcacattca gcttgcacag      360

agtttaagag aagaggccag gaagatggaa gaattcaggg aaaagcaaaa actacaacga      420

aaaaagacag agctcataat ggatgctatc cataaacaaa agagcttaca attcaagaaa      480

accatggatg caaagaagaa ctatgagcag aaatgccggg acaaagatga ggcagaacag      540

gccgtcagcc ggagtgccaa cctggtgaac ccgaagcaac aagaaaagct ttttgtgaaa      600

ctggcaactt caaagaccgc agtagaggac tcagacaaag catacatgct gcacatcggc      660

accctggata aggtccgaga agagtggcag agtgagcaca tcaaggcctg cgaggcattt      720

gaggctcaag aatgtgaacg aataaacttc ttccggaatg cattgtggtt acatgtgaat      780

cagctgtcac aacaatgtgt caccagtgat gaaatgtacg aacaagtccg aaagagttta      840

gaaatgtgca gcattcagag ggacattgaa tactttgtga atcaacgcaa aactggacag      900

attccaccag cacccatcat gtatgagaat ttctactcct cccagaagaa tgcagtccca      960

gcaggaaagg ctacagggcc taacttggca aggagaggac ccctcccaat tcctaaaagc     1020

tcaccagatg atcccaatta ctctttggtt gatgactaca gtttgctcta tcagtaaaat     1080

caatgaaacc agagcttttt ccggctagtg cttctgtgat atggaaaggg cacccagagc     1140

agcaggacct atagccacgt tatgtcagca atgaagactt tgaagtgaac ccttgctata     1200

attttttaga gatttaaaat ttatggtaga catttaggac aacataagca agtagagttc     1260

tgcagttttt tgaagtttac aaattgcccc attctgaaga attattcttt cccagttact     1320

caggttatga atgaattagg ttttcaacat gggaagcatg aaatccactt ctggatttgg     1380

agcatccact tgaggagcag aggtggcagc agaggattct gagccaccaa ctgcagtagt     1440

ggctcctttg gctttgggca gcctggctgt ggagtttcca cggcgacaca cagcctcagt     1500

ggtgcaagat ttaaaattac cttccttttt ggctggaaga cttagaagcc gcctgatcat     1560

actttctcat tttacagatg aggaaataaa gcctacaagt gtgaaattaa tttccttaca     1620

gttttcctag ctgatgaggg acagaaccag aactagagcc tgagcccaac ccacatcact     1680

attcttctaa cccttcctga agttgtgatg ctcatgctga aatttaagat gccaaatatt     1740

tttgccagca ctttttcagt tgggagaatc accagggttt aaatgtcaga tttattttta     1800

tgtggatccc tgtgtatgct gaactacaga gcatgatgtt taatctaatt taaggagcca     1860

ctgattgtaa aacatgccat tattttatgt tgcactaaga aggtggggtc gaggagttgc     1920

caataaactt gggacagact attgatggcc aagcccatct gaatttaaga tgctaaagta     1980

tgaaaaaaat acatcttaga atcaatgaaa taccatattt tgattccatt cctcaagata     2040

attttagagt tataaaacca gtcctcaatt ttgggtcttc acagagaatc tttcccttgc     2100

tagaccccag aattttaaat gcatccgtct tacactttca caaatatttg ggttttcctt     2160

tttcactcac aaacagcagg gaggtcatgt actttttgta caacacctgt gcactatgag     2220

aaaatggtac cttttagtta ttgacaagtt aaaatagcac tctcagtttt tcagtattac     2280

agagagcaaa tagtttcctc tcctgctctg tgcagtagct tttccagaac tatggacaaa     2340

ttgatcagaa gaagattgat tatttcctca tctttttttc ttttttttga gacagagtct     2400

ctctctgtcc cccaggctga agtgcagcgg catgatctca gctcactgca acctctgcct     2460

cccgggttca agtgattctc ctgcctcagc ctcctgagta gctgggatta caggcaccca     2520

ccaccacacc tggctaattt tttgtatttt tagtaaagac agggttttac catgttggtc     2580

aggctggtct caaactcctg acctcaggtg atccacctgc ctcggcctcc caaagtgctg     2640

ggattacagg cgtgagccac tgcgcccggc ctatttcccc acctttcgtg taaggtgcta     2700

ctgaacatga cagcttcttg tcatgacagg aaacttgcat cagttggata tccttttgag     2760

aaactgaatt ttgcaaaggg ccaaatttcc ccaaactgaa cgggctcagg aaatgttcct     2820

ttacactcag aacattctat tttaagtata ttatttattg ttggcagttc ctcagggatt     2880

tcccttttct ctgtattggt cagtgtagtt gatgtaaaac cgttttgtgg atggaaaata     2940

tttttatttt attgctcttt tagtttggta ggttaaataa aggttcttgg taatttggga     3000


<210> 2681
<211> 936
<212> DNA
<213> Homo sapiens

<400> 2681
gcttccggca ccggccgagg tgcgggtcgc ctccagagat cctgtgcctt caaaccctac       60

gagtccatac tttaaaacaa aatgaagaaa gtaaggctta aggaactaga gagtcgcctg      120

caacaagtgg atggatttga aaagcccaag ctacttctgg aacagtatcc taccaggccg      180

cacattgcag catgtatgct ctatacaatc cataacactt atgatgacat tgaaaataaa      240

gtcgttgcag atctaggatg tggttgtgga gtacttagca tcggaactgc aatgttagga      300

gcagggttgt gtgttggatt tgacatagat gaagacgcat tggaaatatt taataggaat      360

gcagaagagt ttgagttaac aaatattgac atggttcaat gtgatgtgtg cttattatct      420

aacagaatgt ccaagtcatt cgatacagta attatgaatc ctccctttgg gaccaaaaat      480

aataaaggga cagatatggc ttttctaaag actgctttgg aaatggcaag aacagcagta      540

tattccttac acaaatcctc aactagagaa catgttcaaa agaaagctgc agaatggaaa      600

atcaagatag atattatagc agaacttcga tatgacctgc cagcatcata caagtttcac      660

aaaaagaaat cagtctgatc atctaaatca cccgaaaatt tcagcaagca tccaatcttt      720

tcttctagag atttctataa aaatatacaa agtgatcaaa aagtttctta aaagcaacaa      780

cagaccagaa atgactcaca ccaccttata gctatacaag aaaaagacta gaaaccaaaa      840

tgctatttta aagtagtttc ttccgccggg gcagcaagag cgaaactcca tctcaaaaaa      900

taataataat aataaataaa taaagtagtt tcatag                                936


<210> 2682
<211> 2221
<212> DNA
<213> Homo sapiens

<400> 2682
gggacttcac cagtgctgcc atgctggccc caggctgtga gttggaccca gaccaagaag       60

tggtgaggac aaggcctgaa gatgtgcctg cttccccttc aacttccacc atgattgtaa      120

gtgtcctgag gcctcccagc catgcttcct gtacagcctg tggaactgtg acttttcaca      180

tagtagagag aatggcttca gttatacctg cctccaatag gtccatgaga tctgacagga      240

atacatatgt tggaaaaagg tttgttcacg ttaaaaatcc ttacttggat ttgatggatg      300

aagacattct ctatcacttg gatttgggaa caaaaacaca caacctacca gcaatgtttg      360

gagatgtaaa gtttgtctgt gtcggtggga gccccaacag aatgaaagca tttgcactgt      420

ttatgcacaa ggagctcggg tttgaggaag ctgaagaaga cataaaagac atctgtgctg      480

ggacagacag atactgtatg tacaaaaccg ggcctgtgct cgccatcagt cacggcatgg      540

gcatcccctc catttctatt atgcttcatg aactcatcaa attactccac catgcacggt      600

gctgcgatgt caccattatt agaatcggta catcaggggg aatagggatt gcaccaggga      660

ctgttgtaat aacggatata gctgtagact ccttctttaa gccccggttt gaacaggtca      720

ttttggacaa cattgtcacc cgaagtactg aactggacaa agaactgtct gaagaactgt      780

tcaactgtag caaagaaatc cccaacttcc caaccctcgt tggacataca atgtgtacct      840

atgattttta tgaaggccaa ggccgactag atggagcact gtgctccttt tccagagaaa      900

aaaagttaga ctacttgaag agagcattta aagctggtgt caggaatatt gaaatggaat      960

ctacagtgtt tgcagctatg tgtggactct gtggtctaaa agctgctgtg gtctgtgtga     1020

cacttctcga cagactcgac tgtgatcaga tcaacttgcc tcatgatgtc ctggtggagt     1080

accagcaacg gcctcagctc ctaatctcca acttcatcag acggcggctt ggactttgtg     1140

actagacgtc ctaactgggc agcccaaccc tcccctgcaa gtttgtagct caagttgtaa     1200

tgtgaaagtc atattttatt tgtggcattt ttatatagtt ctcatccaca tgctaaatgg     1260

aaagacttta tgaaatcctt ctctcttaaa aaggaattta ttgtaaaaga atactcacac     1320

taaattaaat tcaaatttca ttttagaata agttaactaa atcagtctaa taattaaaat     1380

tttaaaactc ctggattatg acatttggag tttcatatgc agcattaatt aagctcacat     1440

caaaatagac cagccatttg cacatagtta ccagtcactc tgtttctgaa accaatccag     1500

aaattcatgt tagaacattg tcaggcactt ctaggtattg gacaagtgac agaaactgat     1560

catccatatt caaaatattt acagaaaaaa gtgtcagtga aatgtaggtc tatatggaaa     1620

agttaccatt aggaaaatat ggccatactg cttttttacc cctgcactat ttcagtgcac     1680

cacagaatag gattcgagat ttacatatgc ctgtttgtga ttttatctca gaatataaca     1740

actctggatt acattttcct ctcaactgaa aaccctcagt aatgcaaaga aaggccttcc     1800

tttttcttca gaatcacaag tgactaaatt gccttctagc cattttttct tgtaaaaaaa     1860

gtgttttgag gaggctgtat tttttattcc atttcaatat taaccaaata ggctgagaaa     1920

ttcatagcaa ttgaattaag acttgagttc aagatgttaa aggaatcctt ttgtatgact     1980

tgtccagacc ggcctattgc cctacccgtt tgattctctg ggaggcatgg tgctcctcct     2040

ggctgcacat gctctctgtg aactgatcgc atcttgggtt cttctcaatt tgacatactt     2100

gggagtcgga atgactggat gggggatggg tagaggatga ctggcacact tgtatagtat     2160

gtaatgttgt gtacatatta tttatatggt tgtggctcaa ataaagttta attccaacac     2220

a                                                                     2221


<210> 2683
<211> 4782
<212> DNA
<213> Homo sapiens

<400> 2683
gccgcggaga cccggcagtt gggggatgcc gacgcctggg ccttgaggat gctgcggaag       60

ctcaccatcg agcagatcaa cgactggttc accatcggca agacggtgac caatgtggag      120

ctgctgggcg cgccgcccgc cttcccggca ggggcggcca gggaggaggt gcagcgccag      180

gacgtggccc ccggcgctgg tcccgcggcc caggctccgg ctctggccca agctccggcc      240

cggccggccg ctgcgttcga aaggtcactc agccaaagga gctcagaagt agagtatatt      300

aacaaataca gacagctcga agcacaagag cttgatgtgt gtcgcagtgt ccaaccaacc      360

agtgggccag gtccaaggcc atctttggct aaattaagca gtgtgacatg catcccaggg      420

acaacttata aatatcctga tttgcctata agtcgataca aggaagaggt tgtgtctttg      480

atagaaagta attccgtggt gattatccat ggggccacgg gaagcggtaa aagcactcag      540

ctcccgcagt atatcttgga ccactacgtt cagcgctccg cctactgcag cattgtggtc      600

acccagcccc ggaagatagg ggcaagcagc atcgccaggt ggatcagtaa agagcgtgcc      660

tggaccctgg gaggtgtggt gggctaccag gtagggctag agaaaatagc aacagaggac      720

accaggctaa tttatatgac aactggagtc ctgcttcaga aaatagttag tgccaagagt      780

ttgatggaat tcacacatat catcattgat gaagtacacg aacgaacaga agaaatggat      840

ttcctgctat tggtagtccg caaactctta agaacaaatt cacgttttgt gaaggtggtc      900

ctgatgtcgg ctaccatcag ctgtaaagag tttgcagact actttgctgt tcctgttcaa      960

aacaagatga atcctgcata tatttttgaa gtggaaggca agccccattc agttgaagag     1020

tattatctta atgatttgga gcacattcat catagcaagc tctctcctca tctcctggag     1080

gaaccggtga taactaagga tatatatgaa gttgctgtct ctctcattca gatgtttgat     1140

gacttggata tgaaggagag tgggaacaag gcttggtcgg gggcccagtt tgtgttggag     1200

cgaagcagtg tgttggtgtt tttgccaggt ctgggtgaaa taaattatat gcatgaactt     1260

ctcacaagcc tggttcataa aaggttgcag gtctatccac tccattcaag tgtggcttta     1320

gaagaacaga ataatgtctt tttaagtcca gtccctgggt acagaaagat tattctgtcc     1380

accaatattg cagagagttc tgtcacagtt ccagatgtca aatatgttat agatttttgt     1440

ttgactagaa ctttggtctg tgatgaagat acaaattatc agagtctgcg attgagttgg     1500

gcttctaaaa ccagctgtaa tcagagaaaa ggccgtgctg gacgagtgtc tagagggtac     1560

tgttaccggc tggtacacaa ggatttctgg gacaactcca tccctgatca tgttgttcct     1620

gagatgttgc gttgtccatt aggaagcacg atcttgaaag tgaaattact tgacatgggt     1680

gagccgagag ctctgctggc cactgccctt tccccgcctg gtctgagtga cattgagcgc     1740

accatccttc tactaaagga ggttggagca cttgcagtga gtgggcagag agaagatgaa     1800

aacccccatg atggtgaatt gaccttctta ggaagagttt tagcccaact tcctgtaaat     1860

cagcaacttg gtaaactcat agtccttgga catgtatttg gatgtctaga tgaatgtctt     1920

attatagcgg cagctctttc tttgaagaat ttttttgcaa tgcctttccg gcagcatctc     1980

gatggatata ggaacaaagt gaatttctct ggcagtagca agagtgactg tattgcactt     2040

gttgaggcat ttaaaacatg gaaggcttgc agacagacag gggagctgcg gtacccgaag     2100

gatgaactta attggggacg gttaaattac attcaaatca agagaattag agaggtggct     2160

gaattatatg aagaattgaa gactagaatc tcacagttca acatgcatgt tgattctcgg     2220

cgacctgtca tggaccaaga gtatatatat aagcagcgat tcatcctaca ggttgtattg     2280

gcaggtgctt tctatccaaa ttactttact tttggacagc cggatgagga gatggcggtg     2340

agggagctgg ctggcaagga ccccaagaca actgtcgtgt tgaaacacat tcctccctat     2400

ggatttcttt actataaaca actacagtct ctctttagac agtgtggtca agtcaaatcc     2460

attgtatttg atggtgcaaa agcctttgtg gaattctcac gaaatccaac agagagattt     2520

aaaacccttc ctgcagtata tatggcaatt aagatgtctc aactaaaagt ttcacttgaa     2580

ctcagcgttc attctgcaga ggaaattgaa gggaaggtgc aaggcatgaa cgtctcaaag     2640

ctcaggaaca caagggtgaa tgtggacttc cagaagcaga cggtagatcc tatgcaagtc     2700

tcctttaaca catcagacag gtcccagaca gttacagatc tccttctaac tattgatgtc     2760

acagaggtgg ttgaagtggg acacttttgg ggatacagga ttgatgaaaa caactcagag     2820

attctgaaaa agcttactgc tgaaatcaac caactgacgc tggtgccctt gcccactcac     2880

ccacatccag acttggtctg tctggcacct tttgctgatt ttgataaaca acgctacttt     2940

agagctcaag tcctttatgt ttctggaaat tctgctgagg tattctttgt agattatggc     3000

aataagtctc atgtagatct acatcttttg atggagattc cctgtcaatt tcttgaactt     3060

cctttccagg ctttggaatt taagatttgc aaaatgagac catcagcaaa gtctcttgtt     3120

tgtggcaagc actggagtga cggggccagc cagtggttcg cctctctggt gagcggctgc     3180

accctccttg tgaaggtctt ctctgtggtg cacagcgtcc tgcacgtgga tgtgtaccag     3240

tactcagggg tccaggatgc catcaacata agagacgtcc tcatccagca gggctatgcc     3300

gagctcacgg aggagtccta cgagtccaag caaagccatg aagttctcaa gggcctcttt     3360

tccaagtcag tagaaaacat gacagatggc tctgtgccct ttcccatgaa agacgacgag     3420

aaatatctca tccggatttt gttagagagc ttttctacca ataaactggg tactccaaac     3480

tgtaaggcag aacttcacgg gccttttaac ccttatgaac taaagtgcca tagtttgacc     3540

agaatatcca aattcaggtg tgtttggatt gagaaggaga gcatcaactc tgtcattatc     3600

agtgacgccc ctgaagacct tcaccagaga atgctggttg cagcttccct ttccatcaat     3660

gcgactggat ctacgatgct gctgagagaa acctctctga tgcctcatat ccctggcctc     3720

ccggctctcc tcagcatgtt attcgcaccg gtgatagagt taaggattga tcagaatggc     3780

aagtactata ctggagtcct ttgtggtttg gggtggaatc cagctacagg ggcttccata     3840

ctgcccgagc acgacatgga gcttgcgttt gacgttcaat tcagcgtgga ggatgtcgtc     3900

gaggttaata ttctcagggc tgctattaac aagctagtct gtgatggacc aaatggatgc     3960

aagtgtcttg ggccagagag agttgcgcag cttcaagaca ttgcccgtca gaagctttta     4020

ggtttgttct gtcagtcaaa accaagggag aagattgttc ccaagtggca tgaaaagccc     4080

tacgagtgga atcaggttga tccaaagctg gtcatggagc aggccgaccg tgagagcagc     4140

agagggaaga acacctttct ctaccagctc cacaaactgg ttgtgctcgg cacctgagca     4200

tgtccacagg tggcctccag cacacccctc aggaagctgt ggaggctgga ttccaggctc     4260

cctccgcaga ctgactttcc tctgtgtctg ggtgttacag tctgtgccca ctgcatccta     4320

aaggcctttt ctttcttctt ttctctttgg gtgatagtca gagagtggtg tttttgttca     4380

ggtgggaagg attggaaact ctagtctttt ctagaaacag aaaatcactg tattaaatat     4440

tttggaaaga ttgttctgaa agaagtctgt ttggataaag agctgtattt tgctttaaat     4500

ttattaaggt aaatataagt agttaatctt agatgtaagg ttccagaatg tgcttacata     4560

ttctgttctg ttacagtgat ttaaaccagt agtataggaa aaaacttaaa aaaacaaaaa     4620

aaccatgtag tattttctga tttttttttc catgagggaa aatatctaat ttttataaga     4680

ctaagttgag ttatacttct tggttcacat tttggaaatc agagattaca gattacatgg     4740

ccatagctta tctgtgttaa aacaataaaa gcattaaatg aa                        4782


<210> 2684
<211> 944
<212> DNA
<213> Homo sapiens

<400> 2684
cagcagccgc gatggacgtg ttcctcatga tccggcgcca caagaccacc atcttcacgg       60

acgccaagga gtccagcacg gtgttcgaac tgaagcgcat cgtcgagggc atcctcaagc      120

ggcctcctga cgagcagcgg ctgtacaagg atgaccaact cttggatgat ggcaagacac      180

tgggcgagtg tggcttcacc agtcaaacag cacggccaca ggccccagcc acagtggggc      240

tggccttccg ggcagatgac acctttgagg ccctgtgcat cgagccgttt tccagcccgc      300

cagagctgcc cgatgtgatg aagccccagg actcgggaag cagtgccaat gaacaagccg      360

tgcagtgagg acccccaaga ggcccatttc ccccaataaa agagatttgg gagtctgcct      420

ggttgctgcc tctttttccc gcccctccct gggatgggtc ccactccctg tgggctcctt      480

ttggggcttg tgcttggcag ttcctgtgct gtcctgtctc ccagatcctg agaccctggc      540

tgagaacttg gcccagcctg ctgcttaaag gcaccatggg gacctgggtt gccctgagac      600

ccaagccatt gttagcagct agccagccac accaaccacg ccagggggag gaaagggaag      660

gactgggaga gacacaaaga ccagagccag cctcagggac aagagattcc agttttaggc      720

ctttctcctt ctaagtgccc cccaccccca tagcctgcat gtccactccc agacgatggc      780

caagagcaga aacacaagct ggagccagtg tcctggtttg acagcatgtt caacgaggga      840

accccaagac ggacccacac aggtccaccc acgctggggg ctgtaatcac ggagggaagt      900

ggctgccccc ttaacacacc tttaataaac agtctacaga ccca                       944


<210> 2685
<211> 3842
<212> DNA
<213> Homo sapiens

<400> 2685
gcgggagctt ctcctgccag gcaggaagac gagtagaagg gagcggcatg ctggaggctg       60

gagcctgagc ccctggggct cgccttgctg tgtttggtgg tgacgtggga cactgcagct      120

cggccagagt ggtagaaatg tcctggtgta ggcttttctg gctttgcccg tctagctgct      180

ccaagccagg ctggaggagg aggagaagga atcacctgtg gtacgctgga gcctgcatgt      240

ggcgtgactc tgcagctcgc ctcgtgtgac tgatggcagc cacggagact gcagctcgac      300

aggagtgatt ggaaacccgg agttacctgc tagttggtga aactggttgg tagacgcgat      360

ctgttggcta ctactggctt ctcctggctg ttaaaagcag atggtggttg aggttgattc      420

catgccggct gcctcttctg tgaagaagcc atttggtctc aggagcaaga tgggcaagtg      480

gtgctgccgt tgcttcccct gctgcaggga gagcggcaag agcaacgtgg gcacttctgg      540

agaccacgac gactctgcta tgaagacact caggagcaag atgggcaagt ggtgccgcca      600

ctgcttcccc tgctgcaggg ggagtggcaa gagcaacgtg ggcgcttctg gagaccacga      660

cgactctgct atgaagacac tcaggaacaa gatgggcaag tggtgctgcc actgcttccc      720

ctgctgcagg gggagcagca agagcaaggt gggcgcttgg ggagactacg atgacagtgc      780

cttcatggag cccaggtacc acgtccgtgg agaagatctg gacaagctcc acagagctgc      840

ctggtggggt aaagtcccca gaaaggatct catcgtcatg ctcagggaca ctgacgtgaa      900

caagcaggac aagcaaaaga ggactgctct acatctggcc tctgccaatg ggaattcaga      960

agtagtaaaa ctcctgctgg acagacgatg tcaacttaat gtccttgaca acaaaaagag     1020

gacagctctg ataaaggccg tacaatgcca ggaagatgaa tgtgcgttaa tgttgctgga     1080

acatggcact gatccaaata ttccagatga gtatggaaat accactctgc actacgctat     1140

ctataatgaa gataaattaa tggccaaagc actgctctta tatggtgctg atatcgaatc     1200

aaaaaacaag catggcctca caccactgtt acttggtgta catgagcaaa aacagcaagt     1260

cgtgaaattt ttaattaaga aaaaagcgaa tttaaatgca ctggatagat atggaagaac     1320

tgctctcata cttgctgtat gttgtggatc agcaagtata gtcagccttc tacttgagca     1380

aaatattgat gtatcttctc aagatctatc tggacagacg gccagagagt atgctgtttc     1440

tagtcatcat catgtaattt gccagttact ttctgactac aaagaaaaac agatgctaaa     1500

aatctcttct gaaaacagca atccagaaca agacttaaag ctgacatcag aggaagagtc     1560

acaaaggttc aaaggcagtg aaaatagcca gccagagaaa atgtctcaag aaccagaaat     1620

aaataaggat ggtgatagag aggttgaaga agaaatgaag aagcatgaaa gtaataatgt     1680

gggattacta gaaaacctga ctaatggtgt cactgctggc aatggtgata atggattaat     1740

tcctcaaagg aagagcagaa cacctgaaaa tcagcaattt cctgacaacg aaagtgaaga     1800

gtatcacaga atttgtgaat tactttctga ctacaaagaa aagcagatgc caaaatactc     1860

ttctgaaaac agcaacccag aacaagactt aaagctgaca tcagaggaag agtcacaaag     1920

gcttaaaggc agtgaaaatg gccagccaga gaaaagatct caagaaccag aaataaataa     1980

ggatggtgat agagagctag aaaattttat ggctatcgaa gaaatgaaga agcacagaag     2040

tactcatgtc ggattcccag aaaacctgac taatggtgcc actgctggca atggtgatga     2100

tggattaatt cctccaagga agagcagaac acctgaaagc cagcaatttc ctgacactga     2160

gaatgaagag tatcacagtg acgaacaaaa tgatactcag aagcaatttt gtgaagaaca     2220

gaacactgga atattacacg atgagattct gattcatgaa gaaaagcaga tagaagtggt     2280

tgaaaaaatg aattctgagc tttctcttag ttgtaagaaa gaaaaagaca tcttgcatga     2340

aaatagtacg ttgcgggaag aaattgccat gctaagactg gagctagaca caatgaaaca     2400

tcagagccag ctaagagaaa agaaatattt ggaggatatt gaaagtgtga aaaaaaggaa     2460

tgataatctt ttaaaggctc tacaattgaa tgagctcacc atggatgatg ataccgctgt     2520

gctcgtcatt gacaacggct ctggcatgtg caaggccggc tttgcgggcg acgatgcccc     2580

ccgggctgtc ttcccttcca tcgtggggcg ccccaggcag cagggcatga tggggggcat     2640

gcatcagaaa gagtcctatg tgggcaagga ggcccagagc aaaagaggca tcctgaccct     2700

gaagtacccc atggaacacg gcatcatcac caactgggat gacatggaga agatctggca     2760

ccacaccttc tacaacgagc tgcgtgtggc tcccgaggag caccccgtcc tgctgaccga     2820

ggccaccctg aaccctaagg ccaaccgcga gaagatgacc cagatcatgt ttgagacctt     2880

caacacccca gccatgtacg tggccatcca ggctgtgctg tccctgtaca cctctggccg     2940

tactactggc atcgtgatgg actctggtga cggggtcacc cacactgtgc ccatctatga     3000

ggggaatgcc ctcccccatg ccaccctgcg cctagacctg gctgggcggg aactgcctga     3060

ctacctcatg aagatcctca ccgagcatgg ctataggttc accaccatgg ccgagcggga     3120

aatcgtgcgt gacatcaaag agaagctgtg ctatgttgcc ctggacttcg agcaggagat     3180

ggccacggtg gcctccagct cctccctaga gaagagctac gagctgcccg atggccaggt     3240

catcaccatc ggcaacgagc ggttccgctg ccccgaggcg ctcttccagc cttgcttcct     3300

gggcatggaa tcctgtggca tccatgaaac taccttcaac tccatcatga agtctgatgt     3360

ggacatccgc aaagacctgt acaccaacac agtgctgtct ggcggcacca ccatgtaccc     3420

tggcatggcc cacagaatgc agaaggagat cgctgccctg gcgcctagca tgatgaagat     3480

caggatcatt gctcctccca agcgcaagta ctccgtgtgg gtcggtggct ccatcctggc     3540

ctcgctgtcc accttccagc agatgtggat cagcaagcag gagtatgatg agtcaggccc     3600

ctccattgtc caccgcaaat gcttgtaggt ggactctgac ttagttgcgt tacacccttt     3660

cttgacaaaa ccaaacttct cagaaaacaa catgagattg gcatggcttt atttgttttc     3720

ttgtttcatt ttttgttttg ttttttattg gcttgactca ggatttaaaa accggaatgg     3780

tgaaggtgac agcagtcggt tggaggaagc ttcctccaaa gttctacaat gtggccaagg     3840

ac                                                                    3842


<210> 2686
<211> 829
<212> DNA
<213> Homo sapiens

<400> 2686
cgcaggttct atagaatttg ccaagactgc tggcctgttt tctaccctga ttccttaggt       60

ggcttctggg acagaattac ggttctctaa gtatttgctt gcagtatatt caacagaaca      120

taagagcaga ttgctccaat attgacaaaa ttcttgaacc acctgaaggc caagatgaag      180

gtgtgtggaa gtatgaacat ttaaggcagt tctgccttga gctaaatgga cttgctgtca      240

aacttcagag tgaatgccat ccagatactt gcactcaaat gacagcaact gaacaatgga      300

tttttctttg tgcagctcat aaaactccaa aagagtgtcc tgctatagac tatactagac      360

acacacttga tggtgctgca tgtcttctga atagcaataa atattttccc agcagggtta      420

gcataaagga atcatctgta gcgaaactag gatcagtatg ccgtaggatt tacagaatat      480

tttcacatgc ttattttcat catcggcaga tatttgatga atatgaaaat gaaacatttt      540

tgtgtcatcg gtttactaag tttgtgatga aatacaattt gatgtccaag gataacctga      600

ttgtaccaat tttagaagag gaagtacaga attcagtttc tggggaaagt gaagcatgaa      660

gggaatcata ggaaaaatgt actgatcata taattaacat tatgtactgt atatatcatt      720

ttagacacat caatcatgta tccatattat agcttctttg tttagtatag gtttttgtat      780

gctgggtttg ccttttaaaa tgggaaatac tttttaagtt attcataag                  829


<210> 2687
<211> 2811
<212> DNA
<213> Homo sapiens

<400> 2687
atggagccag acatcattcg aatgtactct tcatccccac caccattaga caatggagca       60

gaggatgatg atgatgatga atttggggaa tttggtgggt tttcagaagt tagcccttct      120

ggtgtagggt ttgttgattt cgatacacca gattatactc gtcccaagga agagtttgta      180

ccttcaaacc attttatgcc aattcatgaa ttctcagaaa atgtagatag ccttacaagc      240

tttaagtcca ttaaaaatgg taatgataag gacatcactg ctgaactttc tgctcctgtg      300

aaaggacagt ctgatgtttt actttctacc accagcaaag aaataatttc atctgaaatg      360

ttagctactt ccattgatgg catggaaaga ccaggaaatt taaataaagt agtggagcag      420

agacagaatg ttggaacact tgaaagtttc tctccaggag attttagaac taatatgaat      480

gttgttcatc aaaacaagca gttagagagc tgcaatggtg aaaagcctcc ttgtctggag      540

attctaacaa atgggtttgc agtgttggaa actgtaaatc ctcagggaac agatgatctg      600

gacaatgtag ctgattcaaa gggacggaag cctcttagca ctcatagcac tgagtataat      660

ttagactctg tacctagtcc tgctgaggaa tttgcagatt ttgccacatt ttccaaaaag      720

gaaaggatac aattagaaga aatagaatgt gcagttttaa atgatagaga agcactaacc      780

attcgggaaa acaataaaat taatagagtc aatgaactga attctgtaaa agaagtggct      840

ttgggtagaa gcttggataa caaaggagac actgatggag aggatcaggt ttgtgtttca      900

gaaataagca tagtgactaa cagaggtttc agtgttgaaa aacaaggcct tccaacactg      960

caacaggatg aatttttaca gtcaggtgtt cagtcaaagg cttggagttt ggtagactca     1020

gctgataatt cagaagccat taggagagaa caatgtaaaa ctgaagaaaa acttgactta     1080

cttacttcta aatgtgctca cctatgcatg gattctgtta aaacttctga tgatgaagtt     1140

ggttctccca aagaagaaag tagaaagttt actaatttcc aaagcccaaa cattgacccc     1200

acagaagaaa atgatttgga tgattcttta agtgtaaaaa atggtgatag tagtaatgac     1260

tttgtgactt gcaatgatat caatgaagat gattttggtg attttggtga ctttggctct     1320

gccagtggct caactccacc ttttgttact ggtactcaag attcaatgag tgatgccact     1380

tttgaagagt cttcagagca ctttccacat tttagtgaac caggtgatga ctttggagaa     1440

tttggggata taaatgctgt ttcttgccaa gaggagacaa tattaacaaa gtcagaccta     1500

aaacagactt ctgataattt atcagaagaa tgtcaattgg caagaaaatc tagtggaaca     1560

ggcactgaac ctgttgcaaa acttaaaaat gggcaagaag gtgagattgg acattttgat     1620

tctgtgccaa atattcagga tgactgcaat ggttttcaag actctgatga ttttgcagac     1680

ttcagttcag ctggtcctag ccaagttgta gattggaatg cttttgagga tgaacaaaaa     1740

gatagttgtt cttgggctgc ttttggagac cagcaggcta ctgaatctca tcatcgaaag     1800

gaagcctggc agtcacatag gacagatgaa aatattgata ctccaggaac ccccaaaacg     1860

cacagtgtac cttcagcaac ttccaaagga gcagttgcta gtggccattt acaggaatca     1920

gccacttcag ttcagacagc tttattaaac cgcctggagc gaattttcga agcatgtttt     1980

ccttccatac ttgtccctga tgctgaagag gaagttactt ccctgaagca cttgctggaa     2040

acaagcactt tgccaataaa aacgagagag gccttacctg aaagtgggga attgctagat     2100

gtgtggactg agctacagga tatccatgat gcacatggct tgagatacca gtggggcggc     2160

tcccatagca acaagaagct tttgtcctcc ttgggaatag acacccgaaa cattctcttc     2220

acgggcaata agaagcagcc tgttatagtg cccatgtatg cagcaggatt gggtatgtta     2280

gagcccacca aggaaccact gaaaccactt tctgctgcag aaaaaatagc ttccatcggt     2340

cagacagcca ccatgtcacc agatatgaac acatgtacat ctgatcagtt ccaggagtct     2400

ctaccacccg tccagtttga ctggagtagc agtggcctta ctaacccttt agatgctagt     2460

ggaggttcca ctcttctgaa ccttgatttc tttgggcccg tggatgacag tagctctagc     2520

agcagcacca caatcccagg tgtggatccg gagttgtatg agttaacaac ttctaagctg     2580

gaaatctcca cctcaagcct caaagtgact gatgcatttg caagactcat gtctacagta     2640

gagaagacaa gcacatctac caggaaaccg aaaagagaag agcacctaag tgaagaagct     2700

atcaaggtga tcgctggcct tcctgactta acattcatgc atgccaaggt gttgatgttc     2760

ccagccacgt taacaccttc cacaagctct caagaaaaag cagacggata a              2811


<210> 2688
<211> 10992
<212> DNA
<213> Homo sapiens

<400> 2688
tttctaaagt ccctcaggaa aaaaattctg aaacttgagc cacaaattaa gaggcagacg       60

gcttttctcc ttgcaaatga cctgccacac agtccgtcac tgcctctgct agctctgcta      120

cccttgggcc ctgtccacag cccacgtggg agaccttttc acgggatcta ctcggatgtc      180

tgggatctgg ccactaccgc aggctcgaga caacccaggc cataaagaat gctgatggga      240

gaaccatttt cctaattttc aaattgttga gctgtttgcc ataatggatg atcagcaagc      300

tttgaactca atcatgcaag atttggctgt ccttcataag gccagtcgac cagcattatc      360

cttgcaggaa accagaaaag caaaatcttc atcaccaaaa aaacagaatg atgtccgagt      420

caaatttgaa catagaggag aaaaaagaat ccttcagttc cccagaccag ttaaactgga      480

agatctgaga tctaaagcta aaattgcctt tggacagtct atggatctac attataccaa      540

taacgagttg gtaattccat taactactca agatgacttg gacaaagctg tggaactgct      600

ggatcgtagt attcatatga agagcctcaa gatattactt gtaataaatg gaagtacaca      660

ggctactaat ttagaaccat tgccatcact agaagatttg gataatacag tatttggagc      720

agagaggaaa aaacggctat ctataatagg tcctactagt agagatagaa gttctcctcc      780

cccaggttac attccagatg aattacacca ggttgcccgg aatgggtcat tcactagtat      840

caacagtgaa ggagagttca ttccagagag catggaccaa atgctggatc cattatcttt      900

aagcagccct gaaaattctg gctcaggaag ttgtccatca cttgatagtc ctttggatgg      960

agagagctat ccaaaatcac gaatgcctag ggctcagagc tacccagata atcatcagga     1020

attttcagac tatgataacc ctatctttga gaaatttgga aaaggaggaa catatccaag     1080

aaggtatcat gtttcatatc atcatcaaga gtataatgat ggtcgtaaaa cttttccaag     1140

agctagaagg acccagggga ccagcttacg gtctcctgtg agtttcagtc ctactgatca     1200

ttccttaagc actagtagtg gaagcagtat ctttacccca gagtatgatg atagtcgaat     1260

aagaagaagg ggaagtgaca tagacaatcc tactttgacc gtaatggaca tcagcccacc     1320

cagccgttca cctcgagctc cgaccaactg gagattgggc aaactgcttg gccaaggagc     1380

ctttggaagg gtctacctct gttatgatgt tgatacagga agagaattgg ctgttaagca     1440

agttcaattt gaccccgata gtcctgagac cagcaaggaa gtaaatgcac ttgagtgtga     1500

aattcagttg ctgaaaaact tgctacatga gcgaattgtt cagtattatg gctgtttgag     1560

ggatccccag gaaaaaacac tttccatatt tatggaatat atgccagggg gttcaattaa     1620

ggaccaatta aaagcatatg gcgctcttac tgagaatgtg actaggaaat acacccgtca     1680

gattctggag ggtgtccatt atttgcacag taatatgatt gtccatagag atatcaaagg     1740

cgcaaatatc ctgcgagatt caacaggcaa cgtcaaacta ggagattttg gggccagcaa     1800

acggcttcag accatctgtc tctcagggac aggaatgaag tctgtcacgg gcacaccata     1860

ctggatgagc cctgaagtca tcagtggaga aggctatgga agaaaagcag acatctggag     1920

tgttgcatgt actgtggtag aaatgctaac tgaaaagccg ccttgggctg aatttgaagc     1980

aatggctgcc atctttaaaa tcgccactca gccaacaaac ccaaagctgc cacctcatgt     2040

ctcagactat actcgagatt tcctcaaacg gatttttgta gaggccaaac tgagaccttc     2100

agctgatgaa ctcttaaggc acatgtttgt gcattatcac tagcagccag taacctctcc     2160

tgtgcctcta cctagctccc atctattcat tcaccttctc tctgactgca cttttctttt     2220

ttataaaaaa agagagatgg gggagaaaaa agacaagagg gaaagtattt ctcttgattc     2280

ttggttaaat ttgtttaata ataataatat cctaaatttt ttatatttaa tctttttttc     2340

ccttacaaga acttgaagtt ttttttttta atttttataa tgtactgatg tggttcagag     2400

agataaagca ctttagtaca tagtcactct ttttagtaca aacaaatcat ttggaatacc     2460

taaagattgt agagtcattc cctctatcac tgacacatca gtgacgatgg gaagacatgg     2520

aaaacaagga gaagaaaatg atgtataatt tgtagttttt agtgatagta tttaaaatat     2580

atcctcattt gtggggttga gccctaaact ttagtttagg gtaggtactc aacttaaaga     2640

atataggttt cttcttatat ctgtattctt tagatcctaa cctctgtcta ccaacctttt     2700

tgctcagtag gagtcttgat agaagatatg aatctctgag aggtatgttt atttgttaat     2760

cctaaccagt ataataagca aatacactat aatagatcca cgttactgga atctgtaaac     2820

cttgagggat agctttctgc ttaaaaacac acacacacac acacacacac acacggaaaa     2880

cctttatttt aaagtcaagt tgtgagcaaa tagaaataaa agacaaaagg acatcactct     2940

tatcaaatgt gtgagcagta gaagagacca catttacagt caatagaaat aatgaaaaaa     3000

aattaggtgt ttagtgtatt ttaaacagtt ttgttttgtt ttacttgagg gggacgtccc     3060

aaaattaaag gaatggagaa ataatcaaaa tcatgtatac catcttctat ttccagctcc     3120

tgattcccca taggtaacat cccttaggag cgaagagttc aattagtaat gtttatgtgt     3180

tatgtcagga gatgaaaccc ttgttcttag gatcacagaa tactaaagca cctcaaaaaa     3240

acaggtatca tgtgaaacag tggttgccaa aagtggagcg aggatgattt cactaggcat     3300

ttggcaattc ttagagacat ttccggttgt cacaattgga gggatactag taacatgaat     3360

tgggtagagg ccagggatgt tgctaaatag attataatac acaaggaaag cagcctcaaa     3420

gaattacccc tcccaaaatg tcagaagtgc tgaggctgag aaaccctgat gtaaagatca     3480

gtcccagtta taaactgaaa acagctattt acaaagcagt aaatgcaaga aagaaaagga     3540

agtcgcaaag agaaagtgat gtaatgcaaa ttgaggattt tacaagatca gatactgctg     3600

ctttaagtca agggtgaata atctcaacaa acagcaaata gcaatcactt taccagctgc     3660

atattgcacc cacataggta actcttcatt ttaggaacaa actgaatttg aacactgagc     3720

cttttgaact cagccatctc tatatattct ttccttaaaa ttcatgattt tgggcaaaaa     3780

aaaaaaaaaa agcatatcaa aacaaaattt taactactaa tgggaaggtt aaaaagctgc     3840

cacgtatttc tagtacaatg tatccaataa gagcaaggac attgttaaat ggaacaagac     3900

agctgggaaa ggccccacta tctctaatag aattgtgcta ctataaaaca tgaagatatc     3960

agcaatttgg ccacttgcag tttttttcag catgttaaag caagtgctaa gtactttatt     4020

agtactttat ttagtacttt attttaaagg tctagaaaac aacagtcttc ctggaggccc     4080

cagaatccct ttcatgggat tcataaggga ctcaggtatt cttattttct gccaaaaggt     4140

gtgcttattt agggactctt ttacgatact ttgtttctga agttaggtag atcttggttt     4200

actgtgccaa ggtcctacct agcattccct gtaggaatat ttgaaattcc actagctagt     4260

ctaagaagtc aaagcacaaa attaattgtc aacgcttctc tcatattctt aaaattgaag     4320

cagtttgcag ggaagaacaa gaatgaggtg tccctgcctt ggtaaagcaa ctgccaaatt     4380

ttgttctaga aagaatcccc aagtgtgtgg atctattata atttctttat cttttatgaa     4440

tgagggcatc ttttctactt gagcaagatc atggtccttg accagtgggc ttttccttca     4500

tatctgtctt gtgtagttgt gcttttcctt tggctcgttt ttggtctgtc agggtaacca     4560

gcagtgcaca atatgagaca aatgctcttt agagagaaat ctggtgagac tgtagaaccc     4620

agagcaaaac tgtttttttt tcagtctctg ttttcttttc taaatgctat agaaaataaa     4680

ggcacctgaa aagaaactac tactttaaca ctgctgtgga aggcctttgc tttataagaa     4740

aaatattatt agctatggga aagtaatgtt ctttatgtaa agacttaaaa atagactaat     4800

agtttacaga gttattatat aaaatacgat gtgaatttat ttcaaacaag ttgtgaaggt     4860

accaaaaacc acaataaaag ttaatatata taaaaactac tagaacaaaa aagcttgaag     4920

gtgtgggggt ggagggtatg gaagaccaaa agtaaattta aaaaagaaat ttttgaaagg     4980

aaacagcttt atcaggggaa gttaaatata acactccgtt tttttcttct ttctaataat     5040

gatatggatc aacaaatgca atttgaactt tttaagataa ctctaaatgt gttttgtttc     5100

ttaaatgcac aattgattct tctatactgt aatgcttctt tgctgacgct ggaaaatggt     5160

cagactgctg actttgtgcc tttaaaatgc attctgcttt gacagtggca gactttttgg     5220

tgctggagaa gattcactag cagtcttata tgtgcttttc aggaaatatc tttctactta     5280

aggccttgag agattcaaag tggcatgact taggcttgga ccaaatataa gatcttttac     5340

attgcaaaca aaatgttgta ttgaataaaa gggttaaaaa aatcataatg actagtggaa     5400

attttgatgg gttgttaatt atttaaaatg tatttgaaag tatacagact gaaaatttca     5460

gtatgaatat cttgaaaatt ttcagcactt ttccttgttt acaaaacatc tttctaactt     5520

aaaaaaatga ctattgcctt agaaagtttt aaaaggcaca gttaccctta cataacatat     5580

ataaggaatt aaaatattaa tgcatttgct gaactgtaaa agaaaatttt aaaccttgat     5640

ttcagagtga attggattgg ctttcacttg agagagtctt taccttattc ccaaagaaac     5700

tgcattaaaa agatgaaact atttctttag actaagtctc tgctactcca gctcatatat     5760

atgtcagatc tgctctgtag tatttctgac atggagttgt tataagatat gtgaaatcac     5820

ttagaaaata aaatcagatg tgaatagttt agcaggatga ccaagccaga tgcagactcc     5880

ttggcctatg gcaaagttct gtgccagtga ttttatttgg agtctgggaa ctgatagctt     5940

gatataaaat cacctggtgt caattaaata tacaaatcta tcttttttaa tagaatgaat     6000

cttctttgtt tgttcaataa ttgtaactta ttatgtcagg tactaaatta acatccttaa     6060

ggaggtcaca atctaggagg aacatgggca aacagttact tattttatgg catacgctaa     6120

ctctgaaagt tcagcaatga tgttttaaaa tgttattttt tattaaggga aaagcaattt     6180

taggtaatca ttggctgtta taaacggaaa tgtcactgac aacagggatt agagtaaaag     6240

tatctccaaa ctagagggat cccctcccca accaggtcac atagcatctc tctcaggacc     6300

ccctcttact gcaaaaccca gcctctactc aacagttctg gtgatgggga gcatttattc     6360

cataacagtg tttttttgtt cttttttttt tttttcccca gtgtctcttt taaagaaaac     6420

atactttatt ttggtctaaa ttgtgaaaat acccaaaaca tttgatagaa attgaactct     6480

gtcaacagtg ttatttatac taagatcagg acagttcctt gagatcatac tgttttatta     6540

ctaagtttgg cctttgtttt acaaatgtaa tgttcatatt tatttgaatt ttaagattgg     6600

ttaaatgtta atgaaaagca atccaattgt taatttttag tagtgccttt tctctgtatg     6660

ccttaatttt attttatatt aataattcaa gttacccacc aaaatgaaga ttttttccaa     6720

aatcagtagg cttcacaagt tcatttggcc ttagactgtg tattggtcct taaatgtttc     6780

ttaatgcctg cctcctccta cccttttcta cctccttttt aaaaaaataa ataaataaat     6840

aaataaatgt taggagagaa acattaggat ttgtctgtga tagacatgct gcagcttcca     6900

ctagacatga attcccaaca caagcataga aagaggtatt ctcgttctaa agagacatgt     6960

aaatgttttc tgggttgaat atttgatttt caatcacatt ggcactgtcc aagttcttgg     7020

catattatag ttcagttatg attttcatgg tagagttaca atacttgttt ttgccctaaa     7080

gaagtcattc acatggttta caaatgttaa ggcaatgaga taggacagtg agtaggaaat     7140

ccagggatag cagattctag tccttaattc tcagctaaca ttttgggtaa tactcacaga     7200

aaagttactt ttctgtgaag tgtgtgcatg tgtgcatgta tgtgtgcgtt tgcatgcatg     7260

tgtgtgtgtg tgtgtgtgtg gttagagttg gaggcaggga tgggaaggaa gaaggggaaa     7320

ggtatgagtg ttcaattagg tcagtttctg gttttggaag aacaactcaa atgtatgacc     7380

tactgatgac atacagtgag tgtagtcatc cttgggtagg aacaccagta cattttccag     7440

aagtagctag tacaaatgat tgtataataa tattgattgt aaattgccat actcttggtt     7500

gctaaaggta gattaaaatt caatttgtgt atatgtaaaa taatcttata tataattctt     7560

aaatagaaag taattgattt tacatagttc ttcctgaact ttttggaact gaaattctgc     7620

caaacattat caaaataagc ttccttagct taccaagtat tcacaaggaa attctcttgt     7680

acctcttttt ggttggctag gggaagcatg ctgtgaagca gctattccta cttatagttg     7740

tctttggctt ggctttgact tctgccatgg tttggacagg atgccatggt aggtgtggga     7800

agtatcaggg cctcccatct tcccatactc accttccaga gctgttgatg gaaatgagct     7860

cttgggggag cctagagatt cttttttcag tggtcctgta agcattcaag gttgagcttc     7920

agaaagatga gggaggagtc atagctacag taaagaaaag aatagatttt atctgttgcc     7980

tgtatacagt ctcatagaat tcttattttt cataattgtg cattttaatt gatagtcata     8040

tggtattttt gttaataaca gcaaaggcat taaatcagta ccattgttcc ttctgcctga     8100

tgacttcttg tttgtaacac aatctgtatt atcagaatca ctttaaacca aagcttttat     8160

attccctgta cacatagcca aaataattag cactgttact tctgtccact tgtaagctaa     8220

tagtataaaa attataaagc agatactagt agaatttgta ttctggtata tccttcaagg     8280

aaaaggacag gtgatcagtg catttagaca tccagaagtt acttccacta ttgaggaact     8340

atgtagacat gaatttaagc ttgtacatgt gccaatcttg ttaatgtcac ttgaccactg     8400

attcacatag acagacatta acgtctgatg cctcaggttg atggcgaact ttcttcctag     8460

tgtcttaaca tttatgaact tatgtttgac ttgaggggca tttcagcaaa gctgtgagga     8520

aaagtaggtt ctggactgat gtctgctttg tgccatagac attttggaac ataaggaagt     8580

atctgcttct actatatgta caggacttgt ccccaaataa tttctgaatc ccttaatgca     8640

gttgagaatc ccttaatgca gttgagaaca gtaaagttca tgaccatacc gaaaagcact     8700

tttaagttca cttcttttta aatatttttt tagaatttat tttttaaaag catatgtaac     8760

tagtgatgat tttagcatta gctttacttg gaggggagaa gaaacaaaat tacaccttaa     8820

actctattag atagactaca aaatggattt gatgtattct tacttttcca aagaattttt     8880

tccacctgga ataagaagag aggactagtt gaaacatttg agctggagag gcttatgggc     8940

aatatgaagt gggccaaatt cttgcaatac accctattca attgaaagta cagtgtctaa     9000

ggataagaat acttctttaa agaccaacaa ttgttttaat gcaatcttaa ttagtaaatg     9060

gtttacattt tttctattgt tattggtttt aaaatttgct accctgaatt ctgaaatatt     9120

ataagagtta ataccaaaaa tacttttaat gtctgacatc tcttacattt cacatggttc     9180

tttttattca ttgtaaataa aagtaaactt ggataaattt gagaataaac tttgaattgt     9240

tgcaaactat gattatcaat ttgtaaattt accctttgac ataataatgt acatttttaa     9300

atgtagccat taaattctct atatttaacc tattggtttc tctctaaatg tttttaatct     9360

cagttgaatg ctgggcagtt tataattatg tacaaagggt ttttttccta ttaagattga     9420

catttttgca catttttgga aatgtttaat ttgtacactg atttactact ctgaccaata     9480

attgttgatg agtgtatgag catcatgaat gcgtgcattg aactactgtc tgtgtcttta     9540

tgttttaact tctttcaaga tgtagccatc agttactgca ctgctattac tgacttaaat     9600

ggaccttttt gcttttacaa actatactta tctatggttc tttgttgaag aactcaggag     9660

ttcgacatta atagaaatta gaaaatttta taatgtatta taaaatccat tactaagttg     9720

aaagtatgct tttaactgtg tatcagggga tgtatgtttg tgtggagatg tttttttctg     9780

tctgtaggca catgtatata tcccagtaag ttcttatttt catttcattt ctacattttt     9840

atgaacttgt tttataaggg tactgtttag ttgtgataat taaatatata taaaagcttt     9900

ctgagagatt atttactata tgaatatatt ttcagctggc tgatcaaaag tatttttaaa     9960

attttgtttt tagccattca aaatgtattt gtattttcag aattgaatgc aagtcatact    10020

tagagctcaa ttaaaatact cttgcaagaa aaagcattaa attctctttg agaattccgt    10080

gaaatgcaaa ttaagggaaa aataggtttt aagcagtagc aaaaacacac cgctaaaaat    10140

ggcctttgaa ttctcagagc tatggaaaaa tgtgagaaac taaattgtct cgagatgtca    10200

agatttttct atctccagtt gctattggcc tgtcctactg ttgtctttga atatttcctg    10260

tattccaccc caaaagattt caacttttag tttttctatc actgggcaag gtcagactgg    10320

gtttataaaa caatatattg gcatattgtg attctttgta attgactata aattggtttt    10380

gaaatgtcca aacatacgtt gtgtgtcttt atattgtact gtgtgtttta agtaactggc    10440

agaaaaagaa ttggaaatga aatttccaat cagacaatgt agtattaaag aaaactttgt    10500

tttaaatatg cggtaccatg taaaattact cgtgttagga ataaagtcca ctgttgaagt    10560

tgaatgtcac taagcttatt atgttaaaag gaaccagtgt gattaggaaa acctaccaga    10620

agccagatac agtgtggtac gtgcaacatt tcatgcacat tttgattttg tttgtcattc    10680

aaaattgtgc ttgtaaaaat gtatacaatt tctgagtttt ataatttcta ggtacttgtt    10740

ttttcttgct ggtaaatagc ttttttttaa aaaaaaatct aatataaaag aaaccatgtt    10800

tatattttgt tagtgatcaa tgactttgtt tatatggaaa tttgtatatt gttggcacac    10860

attttgttga ggtttacgtg catgaaggcc tgcaataatt agcacaatga aaactgcttt    10920

ttcttacatg ttcatttttt tgaaagattg tggtgcaaag gcttactcta ataagtaacc    10980

ttctggacta tg                                                        10992


<210> 2689
<211> 1032
<212> DNA
<213> Homo sapiens

<400> 2689
agaacgaggg gacgtaacgg aggcaggttg gagccgctgc cgtcgccatg acccgcggta       60

accagcgtga gctcgcccgc cagaagaata tgaaaaagca gagcgactcg gttaagggaa      120

agcgccgaga tgacgggctt tctgctgccg cccgcaagca gagggtggga gtacagcagc      180

caaacgctga acttagtccc atccacttcc atcttatcct ttgtgccctt catccccctg      240

catcttgtcc tttttgccct ctggtacctc ccagtgcccc atcatctcta cccccaggga      300

ctcggagatc atgcagcaga agcagaaaaa ggcaaacgag aagaaggagg aacccaagta      360

gctttgtggc ttcgtgtcca accctcttgc ccttcgcctg tgtgcctgga gccagtccca      420

ccacgctcgc gtttcctcct gtagtgctca caggtcccag caccgatggc attccctttg      480

ccctgagtct gcagcgggtc ccttttgtgc ttccttcccc tcaggtagcc tctctccccc      540

tgggccactc ccgggggtga gggggttacc ccttcccagt gttttttatt cctgtggggc      600

tcaccccaaa gtattaaaag tagctttgta attccttgag cgcctggttt gactggggac      660

ttggggggat ggggttggaa gaatgactgc cctttcccac caaaaaaggg agaactcttt      720

agattcagat tgtgggtatg tagacttaat aagtgaaaca tcacagaaga agcctttatt      780

atacaatgac aaccaaacaa gtactccgga tatgcagtag aggaatcctc taagaaccat      840

agagacttct tttctgtgat ttttgttccc cacccttgaa caccatctct aggatggagt      900

tggcctaaga gtgaatgctg caagatctgt gtttatgcct cttttcctca ttcttcctca      960

gtttgttcgt ctgcttgaaa gttggccaaa aaatcctgct gctcaccgac ttcccgtggt     1020

cagctgctgt ca                                                         1032


<210> 2690
<211> 880
<212> DNA
<213> Homo sapiens

<400> 2690
gtgcgcgcgt gcggcctggc gcttccggca ccggccgagg tgcgggtcgc ctccagaggt       60

gcgtggtcgt ggcgcgaggg atcctgaggc tgctccagca gtgcgccgcc gccgtctcct      120

ggggcggctt gggttagccg ggagatcctg tgccttcaaa ccctacgagt ccatacttta      180

aaacaaaatg aagaaagtaa ggcttaagga actagagagt cgcctgcaac aagtggatgg      240

atttgaaaag cccaagctac ttctggaaca gtatcctacc aggccgcaca ttgcagcatg      300

tatgctctat acaatccata acacttatga tgacattgaa aataaagtcg ttgcagatct      360

aggatgtggt tgtggagtac ttagcatcgg aactgcaatg ttaggagcag ggttgtgtgt      420

tggatttgac atagatgaag acgcattgga aatatttaat aggaatgcag aagagtttga      480

gttaacaaat attgacatgg ttcaatgtga tgtgtgctta ttatctaaca gaatgtccaa      540

gtcattcgat acagtaatta tgaatcctcc ctttgggacc aaaaataata aagggacaga      600

tatggctttt ctaaagactg ctttggaaat ggcaagaaca gcagtatatt ccttacacaa      660

atcctcaact agagaacatg ttcaaaagaa agctgcagaa tggaaaatca agatagatat      720

tatagcagaa cttcgatatg acctgccagc atcatacaag tttcacaaaa agaaatcagt      780

ggacattgaa gtggacctaa ttcggttttc cttttaaaag ccccgcaaac aaaagtcgtt      840

taaaacctat ttaaaatgaa taaaaaattg gtttactaaa                            880


<210> 2691
<211> 2089
<212> DNA
<213> Homo sapiens

<400> 2691
ttttcccctc aggagaagtc gggaaggtgg cggcggcggc ggcggttgtc ccggctgtgc       60

cggttggtgt ggcccgtcag cccgcgtacc acagcgcccg ggccgcgtcg agcccagtac      120

agccaagccg ctgcggccgg gtccggcgcg ggcggcgcgc gcagacggag ggcggcggcc      180

gcggccaggg cggcccgtgg gaccgcgggc ccccggcgca gcgctgcccg gctcccggcc      240

ctgccggcct cctcccttgg cgccgcggcc atggcggcca gcgcgaagcg gaagcaggag      300

gagaagcacc tgaagatgct gcgggacatg accggcctcc cgcacaaccg aaagtgcttc      360

gactgcgacc agcgcggccc cacctacgtt aacatgacgg tcggctcctt cgtgtgtacc      420

tcctgctccg gcagcctgcg aggattaaat ccaccacaca gggtgaaatc tatctccatg      480

acaacattca cacaacagga aattgaattc ttacaaaaac atggaaatga agtctgtaaa      540

cagatttggc taggattatt tgatgataga tcttcagcaa ttccagactt cagggatcca      600

caaaaagtga aagagtttct acaagaaaag tatgaaaaga aaagatggta tgtcccgcca      660

gaacaagcca aagtcgtggc atcagttcat gcatctattt cagggtcctc tgccagtagc      720

acaagcagca cacctgaggt caaaccactg aaatctcttt taggggattc tgcaccaaca      780

ctgcacttaa ataagggcac acctagtcag tccccagttg taggtcgttc tcaagggcag      840

cagcaggaga agaagcaatt tgacctttta agtgatctcg gctcagacat ctttgctgct      900

ccagctcctc agtcaacagc tacagccaat tttgctaact ttgcacattt caacagtcat      960

gcagctcaga attctgcaaa tgcagatttt gcaaactttg atgcatttgg acagtctagt     1020

ggttcgagta attttggagg tttccccaca gcaagtcact ctccttttca gccccaaact     1080

acagcattta gaatgctttc atctagctgc agttttggtg aatttacttc agcttttcct     1140

cttcaggcta cccacagtgg aagtgctgca tcagtaaatg ctaattttgc tcattttgat     1200

aacttcccca aatcctccag tgctgatttt ggaaccttca atacttccca gagtcatcaa     1260

acagcatcag ctgttagtaa agtttcaacg aacaaagctg gtttacagac tgcagacaaa     1320

tatgcagcac ttgctaattt agacaatatc ttcagtgccg ggcaaggtgg tgatcaggga     1380

agtggctttg ggaccacagg taaagctcct gttggttctg tggtttcagt tcccagtcag     1440

tcaagtgcat cttcagacaa gtatgcagct ctggcagaac tagacagcgt tttcagttct     1500

gcagccacct ccagtaatgc gtatacttcc acaagtaatg ctagcagcaa tgtttttgga     1560

acagtgccag tggttgcttc tgcacagaca cagcctgctt catcaagtgt gcctgctcca     1620

tttggagcta cgccttccac aaatccattt gttgctgctg ctggtccttc tgtggcatct     1680

tctacaaacc catttcagac caatgccaga ggagcaacag cggcaacctt tggcactgca     1740

tccatgagca tgcccacagg attcggcact cctgctccct acagtcttcc caccagcttt     1800

agtggcagct ttcagcagcc tgcctttcca gcccaagcag ctttccctca acagacagct     1860

ttttctcaac agcccaatgg ttttgcagca tttggacaaa caaagccagt agtaacccct     1920

tttggtcaag ttgcagctgc tggagtatct agtaatcctt ttatgactgg tgcaccaaca     1980

ggacaatttc caacaggaag ctcatcaacc aatcctttct tatagcctta tatagacaat     2040

ttactggaac gaacttttat gtggtcacat tacatctctc cacctcttg                 2089


<210> 2692
<211> 1103
<212> DNA
<213> Homo sapiens

<400> 2692
tcccagcatc ccctgcactc ggttcctctg taacttagac tccagtgtgc cgcgcagtgt       60

gcgcaaattc acaaacccgc ccgctgagtt ggtcgtttcg gaatcccgag acttgaaacc      120

caacgggaag acccttctca ccctcaaaag aagatgacag cccgcagaga gttaacttct      180

gtttacatgg aactcagaca tctgcaaatc atgatttcaa ggccagagaa tggcagggga      240

acagaaaccc tcaagtaatc tcctggagca gtttatttta ctagccaaag gtaccagtgg      300

ctcagccctc actgctctca taagccaggt cttagaggct cccggagtgt atgtctttgg      360

agaacttctg gagctggcca acgtgcagga gcttgcggaa ggagctaatg ctgcttattt      420

gcagttgttg aacctgtttg cctatgggac atacccagat tacatagcca acaaggagag      480

cctgccagaa ctgagcacag ctcagcagaa caagctgaag catcttacca tcgtgagctt      540

ggcatcaaga atgaagtgta tcccctactc cgtgttgctg aaagacctgg agatgcggaa      600

tctccgggaa ctagaagacc ttatcattga ggctgtctac actgacatca tccagggcaa      660

gctggaccag cgaaaccagc tgctggaagt ggatttctgc attggccgtg acatccgaaa      720

gaaggatatc aataatattg tcaagaccct gcatgaatgg tgtgatggct gtgaagcagt      780

tctactgggc atcgagcagc aagttctgag agccaaccag tacaaagaga accacaaccg      840

aactcagcag caggtagaag cagaggttac caacatcaag aagacactca aagccaccgc      900

atcctcctcg gctcaggaga tggagcagca gctggctgaa cgggagtgtc cccctcacgc      960

tgagcagagg cagcccacca agaagatgtc caaagtgaaa ggtctggtct ccagccgcca     1020

ctagggccgg ctggggcagc tggcactcac caggcctggg tcaggtgggg aggggacacc     1080

aagggcccat ttcctcccct ctc                                             1103


<210> 2693
<211> 1937
<212> DNA
<213> Homo sapiens

<400> 2693
gagaccgctg caagtcccgg ggccctgcct ctatcgtcct aggggttccg cgggcaggag       60

caacccagaa gcaccggtga ggccagcgcg tcctcgcagc catgagcagt gagcaggata      120

aatcggccag caaagaaaaa tccaagaaac cagtaagatt tctaccacag ctgtctatgg      180

agaaattagc cagcaaagaa aagttcaagg caccagcaag agctttacca cagctgtcta      240

tggtgagtac aaagccccac tggcagcagg cagctccatc attccatttg agtgtaaagc      300

aggatgatga gagtccagaa ccatttagtg ttaaaaatga acagtcccat gctgaataca      360

tggaacgttt tggaaaaaag ggcaaattac cccaccaagt tgatgatagt tatgttggac      420

catctacttc caaatcaaag ggcaaatctc cacataaaga acgagaaaac tttagaagta      480

ctcttgttaa tgtcattatg caacaagatg ctgacttaga ctcagctgtc cctgatggaa      540

gcacaattcc aaaaccgacc gcttctgcta tagagaaaga catcttgaga tattactatt      600

atattcacca tggaattgat acagaccatg tagccccaat ggaagattct tggctagaac      660

acgtactgga tttagttcca caacatctga aagtcttcac tgacagcata gttacattat      720

ctgatgaaat gagagaggat tatcttctta gtgtaaggaa atccatagtt gattttgttt      780

taaaagatcc tcgagagaaa ggagatgata agaagacaga tgaacttcca gcccatcgtg      840

ctgaaatgga aattctgcca aaaccttgga ggaaatcttt tttagctgca agcagttata      900

ttagggatca cttgaatgca atgaacccca caatgctggc tgtactagat ttgtggcaca      960

ctaattttaa aaaattacgt ttagttgata tcaaagaatt tcataattgc caggatgcat     1020

tagagctgtc aagttttcag aacattatca tgagacacat ggactctgcc aaagagactc     1080

tacttaaaat gtggtttcca gaagtgcaga atatttatta ccaaggtaat aaaaaaaagc     1140

aattgccaac tggtgacagc agtgccaaat tggaatcttt tttcaactgt gctgctgcac     1200

ttatgacttt acagctgcag gacctcactt tagtctccat gcaagatttc acggacttaa     1260

ttgcacaacc cccagattct gttagagctt ttgaacatcc aggtttcatc atgaggctga     1320

ttcttgataa tgacaccatt aagtttgaac ctgagttgag tgactatata gatatctttc     1380

taaatgttta tgacgtcatg attaaagctg tcagttttgt gccaagagtt gagacaaaat     1440

tgtattccaa gtggagaaac aaagcaaaac caggacattt ttacttttct catattcaaa     1500

ggtctgtcac ctttcagcat tctgaagttt cgtctcctca gaactctcat tttaagattg     1560

tgtcaccctt cagtgttctt ggctttacat ggagatgcca attatgactt ccaactttgc     1620

tcgaccttga ggctttgttt cctggcagcc cctcccatgc atccaccttg ccggaaactc     1680

attaaagcaa agcttagacc accaaggatc agcagggtcc ccagggcagc tgctcacttc     1740

tgcacataat gacctttcaa ctcatgcttt ctctcatttt ggtcccttag actttttttt     1800

ttgttgttat ttccttagct atacgttata aaagataaag tcagctttat tatcctggca     1860

tatttatgtg ttttgaattg agtagttgtt ttctggatat ctattcctca tactaccatg     1920

aatagaagtc tctcaag                                                    1937


<210> 2694
<211> 3793
<212> DNA
<213> Homo sapiens

<400> 2694
gatgccttta actctgccag ggaactggca agcaacaaag aaggtggtga ttggctggat       60

tcttgctcat ggctcctggc agatctgaca aatcctcttg cttttgctct aatctctgtc      120

tggatacttt taggaaaaga accttgttat tatgtactaa agtgaataat ttgtgctctt      180

agagtaggag ttggaactat aggacttgaa ggcaagagca ggtatcttat caaggatcta      240

ctcactcagt ttccctaaag ctctctctcc agatcggatt caaccgcaca tcatgacaga      300

tgttccggct acatttaccc aggctgagtg taatggggat aaaccacctg aaaacggtca      360

acaaacaatc actaaaatca gtgaggaatt gactgatgtg gacagccccc tgccacacta      420

cagggtagaa cccagtctgg aaggtgcact caccaaagga agtcaggagg aaagaagaaa      480

attacaaggg aacatgctgc tcaactcatc catggaggac aaaatgctaa aagaaaaccc      540

agaagagaaa ctctttattg ttcataaggc tatcacagat ctttctctcc aagaaactag      600

tgctgatgaa atgacattca gagaagggca tcagtgggag aagattcctc tgagtggcag      660

taaccaggaa ataagaagac agaaggagag gattactgag cagcctctca aagaggaaga      720

agatgaggac aggaagaaca aaggtcacca ggcagctgaa attgaatggc tgggatttcg      780

aaaacctagc caagctgaca tgttacattc taaacatgat gaggagcaga aggtttggga      840

tgaagaaatt gatgatgatg atgatgataa ttgcaataat gatgaagatg aagttcgagt      900

gatagaattt aagaaaaaac atgaagaggt ttctcaattt aaagaggaag gtgatgcaag      960

tgaggactcc ccactgagca gtgccagttc ccaagctgtg acacctgatg agcagccaac     1020

cttagggaag aagagtgata tctccagaaa tgcttattcc agatacaata caatatccta     1080

tcggaaaatc agaaagggaa ataccaagca aagaattgat gaattcgagt ctatgatgca     1140

tttataaact aactggaact gagaaattct catgcccact aaaggaaaag ctaattctat     1200

tgccccaggg tgcatatttc tatgccttat ttgagttatc acttggaggg aggtggaagt     1260

tgactctctt tttcactgta gaataatgtg gaaataaccc tagataaaaa ttcagtctga     1320

taacctcaaa tcaaaaagct ttaaataaat tcttgggcat ttatctttta aaacttcact     1380

aatatagcat tgtgtgataa gcactaagca gtcagtcccc tgggggaatc tggcataatt     1440

cggctataaa tgtagcaatg cttggaaagg tagtcatcaa atgagactat ttgaggggac     1500

tatttgaaat gattctggta tttcttttgg tatctttctt cctgtacatt ggagtgatgg     1560

aaagtctggt attaaaacct ctcttacttt taaacttgat tttgcagact ctggcaataa     1620

gccttccaaa attctgtgcc ttttctatta tcaccaaaca atatgttaag tggctttcct     1680

tggcatctac agagaaaaca ttctatagcc ctccttccta ggtgttacca ttcactgaat     1740

cttctctcag agggagatga gcaattgtca gtcaggataa ttctgtttgc taaatgttgc     1800

ctttatgctt tcaaactgaa ttaaacccat tgtgaggttg acactgggag gggctagaag     1860

attggtgggc agcagactaa agagttatgt tggatagttt tatttctgtg gctgaaaata     1920

aaatcttgtc tagcacagtt aaagtcatta aaaataaaaa tgacagcttt agcacaattt     1980

taagaaaatg cccctctcta ttaccacatt ttctcttatt aacagtatct cagaataatt     2040

ttctttcctt agaaacctga gagaatgcta gtcataactg tactagttac tatgaaaatg     2100

gaaataatta tcttagaata ttttcaaagt agagcgtgag catgtatttt tagtgggaga     2160

gctctgatag ttgttgggaa tatataattt actggacctc agcccaaatc aagatgctta     2220

aaattgtact tgtggagctt cactcaaacc aatgtgtcaa ataacgtatt gaatatttat     2280

gaaaagagag actatattta tattcttaga tagtttgttc cacaattttt catttcatgc     2340

ttccatatat attaccctga actttctatc accacagata aagattttgt tttgccctgc     2400

aaataaaaag acaattcctt attgtctgaa tgtaatacag tcttcattgt actattcaac     2460

cctttgtttc tttctttttc attttgtgaa aaactccatg ttagtcctct tagatgactg     2520

cttatttatg tgtaacataa atcccacata ttctaatgac aacttcttta atccttccgg     2580

gtcatatatt atatttccat agtatcacat actattattt agttgtttac aagactccaa     2640

tttgaattca ggattacagt gctcctttca ttctttcaaa cagataacat aaaagttctg     2700

ttaccctcat tctatacaac ctatggattt catgtgttac aatatcagtt tccagaataa     2760

agtgagggaa atcaggtctt tattgataaa gttagggaga agattgatgc aataggacaa     2820

tttccaattt aatttagatc ctctaatctt tctacatgga caagctgttt tcttttctag     2880

gttactgata acccctacaa ttttcgactt aacttcaaaa cacagtattg tgttatctat     2940

cacataacag gaccatgttt ttaacctacc atcaagagcc tgtattttga gttattccaa     3000

cagagatgat ggattcctgt agaactagag gtgggtgacc tatggttatg tggcacggca     3060

aagcaagtac ctcttaaggg actctaatat atgctaacgc tggtcctctt agctctgtgc     3120

tctcaccaga caatgaatga actatgaaag atttagtcaa cagaaactat tttagggtat     3180

gtttagttgg taaatgcttc atgttcatgg atgacacaat gtttttgcaa aaaaaccctg     3240

aaactattct ttggcattgg tgtccatggc cctataccgc catcttacac gaaagccaca     3300

gagttgaaag ccacagagtt gaaagccaca gagttaagtg acctcaggta acataatggt     3360

gatggttggc catttgagtc tttgtaacct aggaaagaca aaggtctgat tcagattgca     3420

tgggggattt ttaacatatt tgaaactcag ggggaacatg attaagaaca caaactggta     3480

gctacacatg aaggtttact tgagcttttg tgattcaaag ttcaggggtg gtaaggactc     3540

tggtaccagg gaagagggag aattaattta ttgtgcaaat gctggtattt cttacatgat     3600

tttttgtttt cctctgttgc tagataaata gaaactaata atagctctat ttctctgcca     3660

atataaaatc tacctttcat ataatgctac attgaaggca cagaatttgc taccatctct     3720

ctctccccct acctaccaaa ctatccacaa tttaaataaa gaactgctgt gtctgactta     3780

ctctcaataa aag                                                        3793


<210> 2695
<211> 1370
<212> DNA
<213> Homo sapiens

<400> 2695
tccagaggtg cgtggtcgtg gcgcgaggga tcctgaggct gctccagcag tgcgccgccg       60

ccgtctcctg gggcggcttg ggttagccgg gagatcctgt gccttcaaac cctacgagtc      120

catactttaa aacaaaatga agaaagtaag gcttaaggaa ctagagagtc gcctgcaaca      180

agtggatgga tttgaaaagc ccaagctact tctggaacag tatcctacca ggccgcacat      240

tgcagcatgt atgctctata caatccataa cacttatgat gacattgaaa ataaagtcgt      300

tgcagatcta ggatgtggtt gtggagtact tagcatcgga actgcaatgt taggagcagg      360

gttgtgtgtt ggatttgaca tagatgaaga cgcattggaa atatttaata ggaatgcaga      420

agagtttgag ttaacaaata ttgacatggt tcaatgtgat gtgtgcttat tatctaacag      480

aatgtccaag tcattcgata cagtaattat gaatcctccc tttgggacca aaaataataa      540

agggacagat atggcttttc taaagactgc tttggaaatg gcaagaacag cagtatattc      600

cttacacaaa tcctcaacta gagaacatgt tcaaaagaaa gctgcagaat ggaaaatcaa      660

gatagatatt atagcagaac ttcgatatga cctgccagca tcatacaagt ttcacaaaaa      720

gaaatcagta agtctcttga ttttggctgg tctacattcg gtattgaaaa gctttctggg      780

ccggatgtgg tggttcatgc ctgtaatccc agctactcgg gaggctgagg caagagaatc      840

gcttgaactc aggaggcaga ggttgcagtg agctgagatt gccccactga actccagcct      900

gcgcgataag agtgagactc agtctcgaaa aagaaaaaaa aaggaaagct ttgtgacaag      960

taattatttc tagtgttacc aactttcctg tgtaaatata caaagccagc ctaggagaca     1020

ccataaatgg cctgtgggaa aggcccatcg tcaatagcta atattctagt tctttcctaa     1080

atgctttggg tacaaaaaga aaaaaaaaat caaaaactgt ttttgctctt ttcatatagt     1140

atatatttta ttagttagtt tgtactaata cattctcata ttacaaaggc aatttaatgg     1200

aagaatcttc cttttgatat ttgaatcatc tgaaataaca caaacagaac aatacattca     1260

aagaaatctc atttgcataa caaaaagaca agttaaacaa caaaaaaatt tttcctttct     1320

cacaggtgga cattgaagtg gacctaattc ggttttcctt ttaaaagccc                1370


<210> 2696
<211> 1075
<212> DNA
<213> Homo sapiens

<400> 2696
gacttccggt gctggaggag ggggccggcg gcgagggact ccaggaggac gcgtccaact       60

tcgagaccgg cgggggccgg ctccgctctt ccaacccctc catgtgtgaa gagggcggac      120

gacgcagcgg gggaagaaaa ataagctagt ctaggacaag tgtccaggcg acgtggaacc      180

caggtgtctt ttatgaataa tcaaaagcag caaaagccaa cgctatcagg ccagcgtttt      240

aaaactagaa aaagagatga aaaagagagg tttgacccta ctcagtttca agactgtatt      300

attcaaggct taactgaaac cggtactgat ttggaagcag tagctaagtt tcttgatgct      360

tctggagcaa aacttgatta ccgtcgatat gcagaaacac tctttgacat tctggtggct      420

ggtggaatgc tggccccagg tggtacactg gcagatgaca tgatgcgtac agatgtctgc      480

gtgtttgcag cccaagaaga tctagagacc atgcaagcat ttgctcaggt ttttaacaag      540

ttaatcaggc gctacaaata cctggagaaa ggttttgaag atgaagtaaa aaagctgctg      600

ctgttcttga agggtttttc agagtcggag aggaacaagc tagctatgtt gactggtgtt      660

cttctggcta atggaacact taatgcatcc attcttaata gcctttataa tgaaaatttg      720

gttaaagaag gagtttcagc agcttttgct gtgaagctct ttaaatcatg gataaatgaa      780

aaagatatca atgcagtagc tgcaagtctt cggaaagtca gcatggataa cagactgatg      840

gaactctttc ctgccaataa gcaaagtgtt gaacacttca caaaatattt tactgaggca      900

ggcttgaaag agctttcaga atatgttcgg aatcagcaaa ccatcggagc tcgtaaggag      960

ctccagaaag aacttcaaga acagatgtcc cgtggtgatc catttaagga tataatttta     1020

tatgtcaagg aggagatgaa aaaaaacaac atcccagagc cagttgtcat cggaa          1075


<210> 2697
<211> 2135
<212> DNA
<213> Homo sapiens

<400> 2697
gtgtttcacc acacggagat gtggtcacgt gacttgtcaa ctttcaccca ggatgtctcc       60

cttctgactt ccccttagca accaagtcgc ggcgcttggt tccccagcaa ccgggagacg      120

cgtctgctgc gtggaaccgc cgagttccca gcgcttgaga agggtcttcc tatgttgccc      180

gggctggtct tgaactcctg aactcaagca gtccttccac ctcggcctcc caaagagctg      240

ggattacagg tgaaaattct ggatctgtta tctgtgagga ggccactccg ttgacagttg      300

tgtaaaactc tgctgctttc cccagctcca acctctctgg tcttcaacaa cactatcatc      360

agggaaaacg tgggggaaga tgaaccagcc gtgcaactcg atggagccga gggtgatgga      420

cgatgacatg ctcaagctgg ccgtcgggga ccagggcccc caggaggagg ccgggcagct      480

ggccaagcag gagggcatcc tcttcaagga tgtcctgtcc ctgcagctgg actttcggaa      540

catcctccgc atagacaacc tctggcagtt tgagaacttg aggaagctgc agctggacaa      600

taacatcatt gagaagatcg agggcctgga gaacctcgca cacctggtct ggctggatct      660

gtctttcaac aacattgaga ccatcgaggg gctggacaca ctggtgaacc tggaggacct      720

gagcttgttc aacaaccgga tctccaagat cgactccctg gacgccctcg tcaagctgca      780

ggtgttgtcg ctgggcaaca accggattga caacatgatg aacatcatct acctccggcg      840

gttcaagtgc ctgcggacgc tcagcctctc taggaaccct atctctgagg cagaggatta      900

caagatgttc atctgtgcct accttcctga cctcatgtac ctggactacc ggcgcattga      960

tgaccacaca aaaaagcttg cggaggctaa gcaccagtac agcatcgacg agctgaagca     1020

ccaggagaac ctgatgcagg cccagctgga ggacgagcag gcgcagcggg aggagctaga     1080

gaagcacaag actgcgtttg tggaacacct gaatggctcc ttcctgtttg acagcatgta     1140

cgctgaggac tcagagggca acaatctgtc ctacctgcct ggtgtcggtg agctccttga     1200

gacctacaag gacaagtttg tcatcatctg cgtgaatatt tttgagtatg gcctgaaaca     1260

gcaggagaag cggaaaacag agcttgacac cttcagtgaa tgtgtccgtg aggccatcca     1320

ggaaaaccag gagcagggca aacgcaagat tgccaaattc gaggagaagc acttgtcgag     1380

tttaagtgcc attcgagagg agttggaact gcccaacatt gagaagatga tcctagaatg     1440

cagtgctgac atcagtgagt tgttcgatgc gctcatgacg ctggagatgc agctggtgga     1500

gcagctggag gagactataa acatgtttga aaggaacatt gttgacatgg taggactgtt     1560

tatcgaaaat gtccaaagcc tgatggctca gtgccgggac ctggagaatc accaccacga     1620

gaagctcctg gagatctcta tcagcaccct ggagaagatt gtcgagggcg acctggacga     1680

ggacctgcct aacgacctgc gcgcgggtcg tttccaaaag ttcaattatg tggaggcttc     1740

tggcactttc taagagaagc agttacaggt agaggttgaa gtctgagatt tcccctggag     1800

gtcttcttaa ccttagagtc tgtataatga gtactgtggg ggtgttggaa ccaccatttc     1860

tgatcctgca caatgccatc cggtttgcac cagcacatcc actgatgaat ggtcacaaaa     1920

tcagcagggt cggcctgagg aacctggctc catccctggg gtctgcacgc taagaaggct     1980

ctcccggatg tctgcgctgg gtcccgcggc agcatgtcta tgtctctgga aggagtgtgg     2040

gcatcaaggg cccagacaga gatactatgt tgtcagggcc cagacagaga tactatgttg     2100

tcagggcctg ctttagtgca tgcatcattc actcc                                2135


<210> 2698
<211> 1883
<212> DNA
<213> Homo sapiens

<400> 2698
gttgagtcaa gatggcggcc aaggtggcga agcagcagcc gcggcggcgg cggcggctgg       60

agtgagcgtc cgactcgccg cgccgaacga ggtcccggtg tagggccgcg cgccgtggcc      120

gcgtcccact cctcaggccg gggcgcacgt cggctcccac gcttagccag ctcccggtgg      180

tttcctagaa acatgattgt ttattggcat tgatctcaca gtctggtgag gacttcttta      240

ctgataatgt caagttcagg ttatcctccc aaccaaggag cattcagcac agaacaaagt      300

cgttatcctc ctcactctgt ccagtataca tttcccaaca cccgccacca gcaggagttc      360

gcagtccctg attatcgttc ctctcatctt gaagtgagtc aggcatcaca gcttttgcag      420

caacagcagc agcaacagct tcgaaggcga ccttccttgc tttcagaatt tcacccaggt      480

tctgacaggc ctcaagaaag gagaactagt tatgaaccgt ttcatccagg cccatcccca      540

gtggatcatg attcactgga atcgaagcga ccacgtctgg aacaggtttc tgattctcat      600

tttcagcgtg tcagtgctgc ggttttgcct ttagtgcacc cgctgccaga agggctgagg      660

gcttctgcag atgctaagaa ggatccagca ttcggaggca aacatgaagc tccatcctct      720

ccaatttcgg ggcaaccatg tggagatgat caaaatgctt caccttcaaa actctcaaag      780

gaagagttaa tacagagtat ggatcgtgta gatcgagaaa ttgcaaaagt agaacagcag      840

atccttaaac tgaaaaagaa acaacaacag cttgaagaag aggcagctaa acctcctgag      900

cctgagaagc ccgtgtcccc tcctcctgtg gagcagaaac accgcagtat tgtccaaatt      960

atttatgatg agaatcggaa aaaagcagaa gaagctcata aaatttttga aggtcttggc     1020

ccaaaagttg aactgccact gtataaccag ccatcagata ccaaggtgta ccatgagaac     1080

atcaagacaa accaggtgat gaggaaaaaa ctcattttat tttttaaaag aagaaatcat     1140

gcaagaaaac aaagggaaca aaaaatctgc cagcgttatg atcagctcat ggaggcatgg     1200

gagaaaaaag tggacagaat agaaaataat cctcggagga aagctaaaga aagcaaaaca     1260

agggaatact atgaaaagca gtttccagaa attcgaaaac aaagagaaca gcaagaaaga     1320

tttcagcgag ttgggcagag gggagctggt ctttcagcca ccattgctag gagtgagcat     1380

gagatttctg aaattattga tgggctctct gagcaggaga ataatgagaa acaaatgcgg     1440

cagctctctg tgattccacc tatgatgttt gatgcagaac aaagacgagt caagttcatt     1500

aacatgaatg ggcttatgga ggaccctatg aaagtgtata aagataggca gtttatgaat     1560

gtttggactg accatgaaaa ggagatcttt aaggacaagt ttatccagca tccaaaaaac     1620

tttggactaa ttgcatcata cttggagagg aagagtgttc ctgattgtgt tttgtattac     1680

tatttaacca agaaaaatga gaattataaa gccctcgtca gaaggaatta tgggaaacgc     1740

agaggcagaa accagcagca aattgctcga ccctcgcaag aagaaaaagt agaagaaaaa     1800

gaagaggata aagcagaaaa aacagaaaaa aaagaagaag aaaagaaaga tgaagaggaa     1860

aaagatgaaa aagaagactc caa                                             1883


<210> 2699
<211> 991
<212> DNA
<213> Homo sapiens

<400> 2699
tcacctctta acagaagccc accctccatc cctgacacca tgacccactg ttgctcccct       60

tgctgtcagc ctacctgctg caggaccacc tgctggcagc ccaccactgt gaccacctgc      120

agcagcacac cctgctgtca gccctcctgc tgtgtttcca gctgctgcca gccttgctgc      180

cacccaactt gctgtcaaaa cacctgctgt aggaccacct gctgccagcc catctgtgtg      240

accagctgct gccagccttc ctgctgtagc acaccctgct gccagcccac atgctgtggg      300

tccagctgtg gtcagagcag ctcctgtgca cctgtgtact gcagaagaac ctgctaccac      360

cccacaagtg tttgtctgcc tggttgccta aaccagagct gtggctccaa ctgctgccag      420

ccctgctgcc gcccagcctg ctgtgagacc acctgctgca ggaccacttg tttccagccc      480

acctgtgtgt acagctgctg ccagccttct tgctgctaat caactcccaa gagaactacc      540

atcctcacac aacaaccttc agctcaactg acttgtcttt tgagggacta atttactttg      600

ctgctgacag ccaccatgct ctcacccaaa tttttatgaa ttctctacat gtttaaaatc      660

ttgggaatct gcttgaggga gggcagaata cttcatcctc attccctctt tccttacacc      720

ttgtggatca tgtgccagct tcgtctgttc ttaatttgga gtcatgatct cagctttgtc      780

tcaaaaatca agagcttcat tctttgcttc taaggaattt aggtttctgc aactgatcaa      840

tcatctttgc aattatattt tcattttaaa tatccttctc atggttcttg tatccttctt      900

tcttcttttc acgataactt tgggttatgt ctctggtagc agagattctt acctatatgt      960

ttctgaataa actctgaacc atcttcatct c                                     991


<210> 2700
<211> 3113
<212> DNA
<213> Homo sapiens

<400> 2700
ctctcggtcc catattgaac tcgagttgga agaggcgagt ccggtctcaa aatggagggc       60

catgatccaa aggaaccaga gcagttgaga aaactgttta ttggtggtct gagctttgaa      120

actacagatg atagtttacg agaacatttt gagaaatggg gcacactcac agattgtgtg      180

gtaatgagag acccccaaac aaaacgttcc aggggctttg gttttgtgac ttattcttgt      240

gttgaagagg tggatgcagc aatgtgtgct cgaccacaca aggttgatgg gcgtgtagtg      300

gaaccaaaga gagctgtttc tagagaggat tctgtaaagc ctggtgccca tctaacagtg      360

aagaaaattt ttgttggtgg tattaaagaa gatacagaag aatataattt gagagactac      420

tttgaaaagt atggcaagat tgaaaccata gaagttatgg aagacaggca gagtggaaaa      480

aagagaggat ttgcttttgt aacttttgat gatcatgata cagttgataa aattgttgtt      540

cagaaatacc acactattaa tgggcataat tgtgaagtga aaaaggccct ttctaaacaa      600

gagatgcagt ctgctggatc acagagaggt cgtggaggtg gatctggcaa ttttatgggt      660

cgcggaggga actttggagg tggtggaggt aattttggcc gtggtggaaa ctttggtgga      720

agaggaggct atggtggtgg aggtggtggc agcagaggta gttatggagg aggtgatggt      780

ggatataatg gatttggagg tgatggtggc aactatggcg gtggtcctgg ttatagtagt      840

agagggggct atggtggtgg tggaccagga tatggaaacc aaggtggtgg atatggtgga      900

ggtggaggat atgatggtta caatgaagga ggaaattttg gcggtggtaa ctatggtggt      960

ggtgggaact ataatgattt tggaaattat agtggacaac agcaatcaaa ttatggaccc     1020

atgaaagggg gcagttttgg tggaagaagc tcgggcagtc cctatggtgg tggttatgga     1080

tctggtggtg gaagtggtgg atatggtagc agaaggttct aaaaacagca gaaaagggct     1140

acagttctta gcaggagaga gagcgaggag ttgtcaggaa agctgcaggt tactttgaga     1200

cagtcgtccc aaatgcatta gaggaactgt aaaaatctgc cacagaagga acgatgatcc     1260

atagtcagaa aagttactgc agcttaaaca ggaaaccctt cttgttcagg actgtcatag     1320

ccacagtttg caaaaagtgc agctattgat taatgcaatg tagtgtcaat tagatgtaca     1380

ttcctgaggt cttttatctg ttgtagcttt gtctttttct ttttcttttc attacatcag     1440

gtatattgcc ctgtaaattg tggtagtggt accaggaata aaaaattaag gaatttttaa     1500

cttttcaata tttgtgtagt tcagtttttc tacattttag tacagaaact ttaacaaaat     1560

gcagtttcga aggtgtttcc ttgtgagtta acaagtaaag aagatcattg ttaattacta     1620

ttttgtatga attttgctaa agttaactgt aaagaaacac ctgctgactt gcagtttaag     1680

gggaatctat tctccccatt tccaaaccat gatatgaatg ggcgctgaca tgtggagaga     1740

atagataatt tgtgtgtttg caatgtgtgt tttagataaa taggattggg tatttaaatt     1800

agcatttgtg aatttaatag cattaagatt accttcaaat gaaaaaaaat ctcaaaattt     1860

ctatttggtt tttgtgcatt ttcttttaaa atgtaatcat atgattttag tgtgttagac     1920

ttgctgagtc ctagctgtgt ttagaacatc tctattctac atttaccttg gtcaaatttg     1980

aactgctgcc ataggttttg ggtgtaaaga atgtttactg ccctccattt aaattctgaa     2040

aagggatggt ggatgttttc cctctcctac gttagaaacc attcttaaaa acttttgaaa     2100

atatagaacc attaagcctg ctatatctga gcaaattagt gggtaccttt tttttcttat     2160

ttaaagcaca agaggcccat aaatcttgag ttactttaaa ttcttttttt tgatacaagt     2220

tttcagagca agagaataaa aatcatgtgt tattaaaccc ctaactggct ggcatgcttt     2280

cctgtttgta ttctatacat tttgctggat gaaaccaagg atagttcagg tataattgtc     2340

caaaataacc taactgcagc agaaatgtag cacagttgct tagtacaggc ttctcacttc     2400

ctacagacct gaattcaaat ttggatagtc tgagttctta aattcccaaa gaacacactg     2460

ttatttcttg tgtatatttc aacataaatc atgttgttac caatttgttt ggaaggccct     2520

ggttgagaag agttttagtt aataaggtca tatatacata tattaatata aaccaatgtc     2580

tactgttttg ctccagctag tgcttacagt ttcattcgag ccctgagtat gtgccctgct     2640

gttactctct ttggtagttg aacgttgaat tcaagtcttt tgttttaaga agtactaagc     2700

aaacaagcaa taaaaagggg aatggggtgt gctagtgttt gaatatgctc tcttgttgct     2760

ctaattctgt gcctctgtgc attaatattt ggatgcatgc aatgccagca tggaaattgg     2820

tcttcacaca tactgcagtt ttccagaaac attcacaaac caataaatgt aacagacatt     2880

ccatttgtta atgggcatat atgtgaaaag cagtgtagaa aataggctaa tattagaaaa     2940

tggttaagtc ctaaataact tcaagtgtgg ttatataatg gacactgtca atgttcataa     3000

cttaaacctg ggtacctggt caaaataatg cttgggaaac attaaaattg agctaaattg     3060

tctcaagttc ttttattcat ataaataaag tttaaaggaa tgggggagat taa            3113


<210> 2701
<211> 615
<212> DNA
<213> Homo sapiens

<400> 2701
gcgcgtggcg ggcaggcggc aggaggcggg tgggtcaagg taactctggg ctacagagtc       60

cttgctgggg gttcggggag cgcttggacc ccggcttctg ggacgcgtca ggtcgccgtg      120

aagatgattg catgagatcg tgcgtgtgaa cgtttgttga cagctgttac ttgagtccga      180

cagccctggg ggccgtgcat ctgcgtaaca tggctacctc tgaactcctt gggggacacg      240

tatatctttg agaatccgat gaaaaccaga gattccgccc ttgttttctt agaattaaaa      300

ttaccacaga ctgggtaatt tataaagaaa agaagtttat ttggctcaca gttctggaga      360

ctgggaagtc caagagcatg gtgcaagtat ctggagaagg gagcactggc tttgctttca      420

tcaggccaaa gatgcctttc tttgggaata cgttcagtcc gaagaagaca cctcctcgga      480

agtcggcatc tctctccaac ctgcattctt tggatcgatc aacccgggag gtggagctgg      540

gcttggaata cggatccccg actatgaacc tggcagggca aagcctgaag tttgaaaatg      600

gccagtggat agcag                                                       615


<210> 2702
<211> 1103
<212> DNA
<213> Homo sapiens

<400> 2702
cgcggctcca gggccacgtt ccagggtcgg gtttggtgga ttcctcagtc cctgccgccg       60

cggggcgccc tgggatagcg gcggggcctc ctgaacagat ctcggcccct ttccaaacac      120

tcctgatgcc tcatttgcct ctcgcctctt ttcgaccacc attttggggg ctgaggcact      180

cacggggcct ccccaggttt cactccgttt ctacacagtc ggagccccat ggatctccca      240

tctcccggag gaaccgtgaa gccaaacaga agcgcctgcg agagaagcag gcgactctgg      300

aggctgagat agcaggggag agcaagtcac ctgcagaatc cattaaggcc tggaggccta      360

aggagttagt attgtatgaa atccctacga aacccggtga aaagaaagat gtctctgggc      420

ccctgcctcc tgcatacagc ccccgatatg ttgaggctgc ctggtacccg tggtgggtac      480

gagagggctt cttcaaacca gaatatcagg cccggctgcc ccaagctaca ggggagacct      540

tttccatgtg tatcccacct cccaatgtca ctggctccct gcacattggc cacgcactca      600

cggtggccat acaggatgcc ctcgtgcgct ggcaccggat gcgtggggat caagtgctgt      660

gggtccctgg ttcagatcat gcaggaattg ctacacaagc tgtggtggag aaacaactgt      720

ggaaggaacg gggagtgagg agacatgagc tgagccggga ggccttcctt agggaggtgt      780

ggcagtggaa ggaggcgaaa ggtggagaga tctgtgagca gctgcgagct ctgggtgcct      840

ccctggactg ggatcgagag tgttttacca tggatgttgg ctcctcagtg gctgtgactg      900

aagcttttgt gcggctctac aaggcggggt tgctgtaccg gaaccatcag cttgtcaact      960

ggtcatgtgc tttaagatca gccatctcgg acattgaggt ggagaaccgg cccctgcctg     1020

gccacacaca gcttcgactg cctggctgcc ccacccccgt gtcttttggc ctcctatttt     1080

ctgttgcctt ccccgtggat gga                                             1103


<210> 2703
<211> 2031
<212> DNA
<213> Homo sapiens

<400> 2703
atgattcccc cacaggaggc atccgctcga cggcgggaga ttgaggacaa gctgaagcag       60

gaggaggaga ctctgtcctt catccgagac agcctggaga agagcgacca gctcactaag      120

aacatggtgt ctatcttatc atcctttgag agccgcctta tgaagctgga gaactccatc      180

atccctgtgc acaagcagac ggagaatctg cagcggctgc aggagaatgt tgagaagacg      240

ctgtcctgcc tggaccatgt catcagctac taccatgtgg ccagtgacac tgagaagatc      300

atcagagagg gccccacagg taggctggaa gagtacctgg gaagcatggc caagattcag      360

aaggcagtgg agtatttcca ggacaacagc ccagacagcc cggaactcaa caaagtgaaa      420

ctgctctttg agcgcgggaa ggaggccctg gagtccgaat ttcgcagcct gatgacgcgg      480

cacagtaagg tcgtctcgcc cgtgctcatc ttggatctga tcagtggtga cgatgatctg      540

gaggcccagg aggacgtgac cctggagcac ctgcccgaga gcgtgctcca ggatgtcatt      600

cgcatctccc gctggctggt ggaatatggc cgcaaccaag atttcatgaa cgtctactac      660

cagatacgct ccagccagct ggaccgctcc atcaaaggac tgaaggagca tttccataag      720

agcagttctt cctctggggt tccctactcc cctgctatcc ccaacaagag gaaagacaca      780

cctaccaaga agccagtcaa gcggccaggt cacgagcatg atttccgagt taagcacctg      840

tccgaggcct tgaacgacaa gcacgggccg ctggccggga gagatgacat gctggacgtg      900

gagaccgatg cctacatcca ctgcgtcagt gccttcgtca agctggcgca gagcgagtac      960

cagctgctgg ccgacatcat ccccgagcac caccagaaga agaccttcga ctccctgata     1020

caggatgccc tggatgggct gatgcttgaa ggggagaaca tcgtgtctgc tgcccggaag     1080

gccattgtgc gacacgactt ctccacggtg ctcaccgtct tccccatcct gcgacacctc     1140

aagcagacca agcctgagtt tgaccaggtg ctccagggca cggctgccag cacaaagaac     1200

aagctgcctg gcctcatcac atccatggag accatcggtg ccaaagcgct ggaggacttc     1260

gcagacaaca tcaagaatga cccggacaag gagtacaaca tgccgaagga cggcaccgta     1320

cacgagctca ccagcaatgc catcctcttc ctgcagcagc ttttggactt ccaggagacg     1380

gcaggcgcca tgctggcctc ccaagagacc agctcttcgg ccaccagcta cagctctgag     1440

ttcagcaagc ggctgctaag cacctatatc tgtaaagtgc tgggcaacct gcagttgaac     1500

ttgctgagca agtccaaggt gtacgaggac ccagctctga gcgccatctt cctgcacaac     1560

aactacaatt acatcctcaa gtccctggag aagtctgaac tgatccagct ggtggcagtg     1620

acacagaaga ctgctgagcg ctcctaccgg gagcacattg agcagcagat ccagacctac     1680

cagcgcagct ggttaaaggt gactgattac atcgcagaga agaatctacc tgtgttccag     1740

ccgggagtca agctccggga caaggagcgg cagattatca aggagcgttt taagggcttc     1800

aatgatggcc tcgaagaact gtgcaaaatc cagaaggcct gggctattcc agacacagag     1860

cagagggaca ggattcgcca ggcccagaag accattgtca aggagaccta cggggccttt     1920

ctacagaagt ttggcagcgt gcccttcacc aagaacccgg agaagtacat caagtacggg     1980

gtggagcagg tgggcgacat gatcgatcgc cttttcgaca cctctgcctg a              2031


<210> 2704
<211> 590
<212> DNA
<213> Homo sapiens

<400> 2704
agagatgtct tccaaggaca agggagaggg gattatacaa gagtgaggtg ttgtccctga       60

tatagacctg aatgggctca gccctagaca cacttttaaa gctctctctc cagatcggat      120

tcaaccgcac atcatgacag atgttccggc tacatttacc caggctgagt gtaatgggga      180

taaaccacct gaaaacggtc aacaaacaat cactaaaatc agtgaggaat tgactgatgt      240

ggacagcccc ctgccacact acagggtaga acccagtctg gaaggtgcac tcaccaaagg      300

aagtcaggag gaaagaagaa aattacaagg gaacatgctg ctcaactcat ccatggagga      360

caaaatgcta aaagaaaacc cagaagagaa actctttatt gttcataagg ctatcacaga      420

tctttctctc caagaaacta gtgctgatga aatgacattc agagaagggc atcagtggga      480

gaagattcct ctgagtggca gtaaccagga aataagaaga cagaaggaga ggattactga      540

gcagcctctc aaagaggaag aagatgagga caggaagaac aaaggtcacc                 590


<210> 2705
<211> 873
<212> DNA
<213> Homo sapiens

<400> 2705
gaggggagtg gaggggaggc ctcgcctggc ccaccttcct cctgcccctc taccatgtgg       60

cccttcccga gccgctctct cttcccaccc ccgactcagg cctggctcca gacggtctcc      120

tcagaccctg aggcccaggg ctggggggcc tggaacgaga ccaaggagat tctggggcca      180

gagggtgggg aagggaagga ggagaaagag gaggaagagg atgcagagga agaccaggat      240

ggggatgcag gctttctgct gtctctgctg gagcaagaga acctggctga gtgcccattg      300

cctgaccagg agctggaggc catcaagatg aaggtgtgtg ccatggagca ggccgagggg      360

acgccacggc ctccaggagt gcagcaacag gccgaggaag aggagggcac cgcggccggg      420

cagctgctga gccctgagac cgtgggctgc cccctctctg ggacccccga ggagaaggtg      480

gaggctgacc acagatccgt ctacgtgggc aacgtggact acgggggctc cgccgaggag      540

ctggaggccc acttcagccg ctgtggggag gtccaccgag tcacgatcct gtgtgacaag      600

ttctctggac accccaaggg gtgctgccga aaagaaccaa cttccctggg atcagctcca      660

cagaccgcgg gggccttcga ggacacccag gctccagggg ggcacccttc ccccacagcg      720

gcctccaggg caggccccgg ctcagaccac aagggcagaa ccgggcccgt ggaaaattct      780

caccatggtt ttcaccgtat taaagggaag acccgatttt gagagagggg ctggggcctg      840

gatcaggagt aaaccacttg tgctccatcc tgg                                   873


<210> 2706
<211> 3678
<212> DNA
<213> Homo sapiens

<400> 2706
gaggcggtgg cggcggaggc ggcaccgatt gctgtgtcgg ccccagtgcg gccgaagtcg       60

cggtagagcg tagccccacg cccctccccc gtccgcgccc tccctctttc cctggggatg      120

gagaaggcga cggttccggt ggcggcggcg acggctgcag aaggagaagg gagccccccg      180

gcggtggcgg ctgtggcggg cccccccgcg gcggcggagg tcggcggcgg cgttggcggc      240

agcagcagag ctcgctcggc ctcgtctcct cgtgggatgg tgcgagtctg cgacctgctc      300

ctgaagaaga agccgccgca gcagcagcac cacaaggcca agcgtaaccg gacttgccga      360

ccccccagca gcagcgaaag cagcagcgac agcgacaaca gcggcggcgg tggaggcggc      420

ggtggaggcg gaggtggcgg cggcggcacc agcagtaaca acagcgagga agaagaggac      480

gacgacgacg aggaagagga ggtttctgag gtggagtctt tcattttgga tcaggatgat      540

ttggaaaatc caatgctgga aacagcttcc aagttgctct tatcaggtac tgctgatggt      600

gcagacctca ggacagtaga tccagaaaca caggctagac tggaagcttt actagaagct      660

gcaggaatag gaaaattgtc cacggctgat ggtaaagcct ttgcagatcc tgaagtactt      720

cggaggttga catcgtctgt tagttgtgcg ttggatgaag ctgctgctgc acttacccgt      780

atgagagctg aaagcacagc aaatgcaggg cagtcggaca accgcagttt ggcagaagcc      840

tgttcagaag gagatgtaaa tgctgtgcga aagttactca ttgaagggcg aagtgtaaat      900

gaacacacag aggaagggga gagcctcctt tgtttagctt gttctgctgg atactatgag      960

cttgcacagg ttttgttggc aatgcatgca aatgtggaag ataggggaat caaaggtgac     1020

attacacctt taatggctgc tgctaatgga ggacatgtca aaattgtgaa gttgctgcta     1080

gctcataaag cagatgttaa tgcacagtct tcaacaggca atacagcact tacatatgct     1140

tgtgctggag gctatgtaga tgttgtaaag gtgctcttgg aatccggtgc tagtattgag     1200

gaccataatg aaaatggtca tacccctctt atggaagctg gaagtgctgg acatgtggaa     1260

gtagccagat tgctgctaga aaatggggct ggcattaata cgcattctaa tgaatttaaa     1320

gagagtgccc ttaccttagc ttgttacaaa ggacacttag agatggtgcg atttcttttg     1380

gaagcaggcg cggatcaaga gcataaaaca gatgaaatgc acactgctct gatggaggct     1440

tgcatggatg gccatgttga agtagctagg ttacttcttg acagcggtgc ccaagtgaac     1500

atgcctgctg attcatttga gtcaccatta actttggctg catgtggtgg gcatgtggaa     1560

cttgcggctt tacttattga aagaggagct agcctggaag aggtcaatga tgaaggttat     1620

acaccattga tggaagcagc tcgagaagga catgaagaaa tggtggcatt acttcttggt     1680

caaggagcaa atatcaatgc acagacagaa gaaactcaag aaactgcctt gactctggct     1740

tgctgtggag gctttctgga agtggcagac tttctaatta aggcaggagc cgatatagaa     1800

ctagggtgtt ctaccccttt aatggaagct gctcaagagg gtcatttgga gttagttaaa     1860

tacttattag ctgcaggagc taacgttcat gcaacaacag caacagggga tacagcacta     1920

acatatgcct gtgaaaatgg tcatactgat gtagcagatg tcttacttca ggcaggcgca     1980

gatctggaac atgaatctga aggtggaaga actcctttaa tgaaagctgc aagagctggt     2040

catgtttgta ctgttcagtt cttaattagt aaaggagcga atgtgaatag aaccacagct     2100

aataatgacc atactgtact gtccctggct tgtgcagggg gtcatctggc agtggtggaa     2160

ctacttttgg ctcatggggc agatcctact caccgtttga aagatggctc aactatgttg     2220

atagaagcag caaaaggtgg ccatacaagt gttgtttgct atctcttgga ttatcctaat     2280

aacttgcttt cagcccctcc accagatgtc actcagttaa ctcccccatc ccacgattta     2340

aatagggctc ctcgtgtacc agttcaagca ctgcccatgg ttgttccacc tcaggagcct     2400

gacaaaccac ctgccaatgt tgccaccact cttcccatca ggaataaagc tgcttctaaa     2460

caaaagtcca gcagccattt gccagcaaac agccaggatg tacagggtta catcaccaat     2520

cagtctccag agagcattgt agaagaggct cagggaaagt taacagaact ggaacagagg     2580

ataaaagaag ccatagaaaa gaatgcacag ctgcagtcct tggaactggc tcatgctgac     2640

caacttacca aggagaagat cgaggagctc aacaaaacaa gggaggaaca aattcagaag     2700

aaacaaaaga ttttggagga actacagaaa gtagaacgag agttacaact gaaaactcag     2760

cagcagctaa aaaagcagta tctagaggtt aaagctcaaa gaattcaact tcagcaacag     2820

cagcaacagt cttgccaaca cctgggatta ctaactcctg ttggagttgg agagcagctt     2880

tctgagggag actatgcacg gttacagcaa gtggatcctg ttttacttaa agatgaaccc     2940

cagcagactg ctgctcagat gggttttgcg ccaatccagc ctctggcgat gcctcaagct     3000

ttgcctctgg cggcaggtcc cttgcctcca gggtccatcg caaatcttac agaactgcaa     3060

ggagtgatag ttggacagcc agtactgggc caagcacagt tggcagggct ggggcaagga     3120

attctgacag aaacacaaca agggttaatg gtagccagcc ctgctcagac cctcaatgac     3180

acgctggatg acatcatggc agcagtcagt ggaagagcat ctgcaatgtc aaacactcct     3240

acccacagta ttgctgcatc catttcccaa cctcagactc caactccaag tcctatcatc     3300

tctccttcag ccatgcttcc tatctaccct gccattgata ttgatgcaca gactgagagt     3360

aatcatgaca cggcactaac acttgcctgt gctggtggcc acgaggaact ggtacaaaca     3420

ctgctagaga gaggagctag tatagagcac cgagacaaga aaggttttac tccactcatc     3480

ttggctgcca cagctggtca tgttggtgtt gtggaaatat tgctggacaa tggtgcagac     3540

attgaagccc agtctgaaag aaccaaggac acaccactct ccttggcttg ttctggggga     3600

agacaggagg tggtggagct attgttagct cgaggggcaa ataagagcac aggaatgttt     3660

ctgattacac acctctaa                                                   3678


<210> 2707
<211> 2886
<212> DNA
<213> Homo sapiens

<400> 2707
ctgcagcttc cccgggcgct gcctggacag gcctgcctgc gtgctgggac atgtctggcc       60

tccaaggacc gtcggtgggc gatggctgca acggtggagg ggccagagct ggaggcagct      120

gctgccgcag gagatgcttc agaggattcg gacgcagggt ccagggcgct gcctttcctg      180

ggcggcaacc ggctgagctt ggacctgtac cccgggggct gccagcagct gctgcacctg      240

tgtgtccagc agcctctgca gctgctgcag gtggaattct tgcgtctgag cactcacgag      300

gaccctcagc tgctggaggc caccctggcc cagctgcctc agagcctgtc ctgcctccgc      360

tccctggtcc tcaaaggagg gcaacgccgg gacacactgg gtgcctgtct ccggggtgcc      420

ctgaccaacc tgcccgctgg tctgagtggc ctggcccatc tggcccacct ggacctgagc      480

ttcaacagcc tggagacact gccggcctgt gtcctgcaga tgcgaggtct gggtgcgctc      540

ttgctgtctc acaactgcct ctctgagctg cctgaggctc tgggggccct ccccgccctc      600

accttcctca cagtgacaca caaccgcctg cagacgctgc ccccagcact gggggcccta      660

tccaccctgc agcgcctcga tctctctcag aatctgctgg acacgctacc tcctgagatt      720

ggaggcctgg gcagcctcct ggagctcaac ctggcctcca accggctgca gagcctccca      780

gcctctctgg cgggacttcg gtccttgcgg ctccttgtcc tgcacagcaa cctcctggcc      840

tctgtgccag ctgacttggc ccgccttcca ctcctcaccc ggctcgacct gagggacaac      900

cagctccggg acctgccccc tgagctgcta gacgccccct ttgtgcgcct gcaggggaac      960

cccctgggtg aggcctcgcc agacgccccg agttcaccag tggcagccct cattccagaa     1020

atgcccagac tgttcctgac ctcagatttg gacagctttc ctgtgacccc tcaaggctgc     1080

tcagtgaccc tggcctgtgg cgtccgcctg cagttcccag cgggagccac cgccaccccc     1140

atcaccatcc gctatcggct gctgctgccg gagccaggcc tcgtccccct gggtcctcat     1200

gacgccctgc tcagccatgt gctggagctg cagccccatg gggtggcctt ccagcaggat     1260

gtggggctgt ggctgctctt caccccaccg caggcccggc gctgccgtga agtggtggtc     1320

aggacccgga atgacaacag ctggggtgac ctggagacct acctggagga agaggcaccc     1380

cagcggctct gggctcactg ccaggtgccc cacttctcct ggttccttgt ggtttcccgc     1440

cctgtgtcca atgcctgcct ggtgccaccg gaggggacac tgctgtgctc ctcgggtcat     1500

cctggggtca aagtcatctt cccccctggg gccactgagg agcctcgtcg agtctccatg     1560

caggtggtgc gcatggctgg ccgagagctg caggccctcc tgggagaacc agaggctgca     1620

gtgagccccc tgctgtgcct gtcacagagc ggtcccccca gcttcctcca accggtcacc     1680

gtgcagctgc ctctgccctc tggcatcaca ggcctcagtc tggaccgctc ccgcctgcac     1740

ctgttgtact gggcccctcc tgcagccacc tgggatgaca tcacagctca ggtggtcctg     1800

gagctcaccc acctgtacgc acgcttccag gtcacacact tctcctggta ctggctctgg     1860

tacaccacca agaactgtgt gggaggcctg gctcggaagg cctgggagcg gctgcggctg     1920

caccgtgtga acctcatcgc tctgcagcgg cgccgggacc ctgagcaggt cctgctgcag     1980

tgcctgcccc gaaacaaggt ggacgccacc cttcggcggc tgctggagcg gtaccggggc     2040

cccgagccct ctgacacggt ggagatgttc gagggcgaag agttctttgc ggccttcgag     2100

cgcggcatcg acgtggatgc tgaccgccct gactgtgtgg agggcagaat ctgctttgtc     2160

ttctactcgc acctgaagaa tgtgaaggag gtgtccttct accgtggcgc ggtgcctgtg     2220

cgggtgcccg aggaggctga ggctgcccgg cagaggaagg gcgcagacgc cctgtggatg     2280

gccactctgc ccatcaagct gccgagactt cgagggtccg aggggccacg gcggggggct     2340

ggcctctcct tggcaccctt gaatctggga gatgccgaga ccggctttct gacgcagagc     2400

aacctgctga gtgtggctgg gcgtctgggt ctggactggc cagccgtggc cctgcacctg     2460

ggggtgtcct accgggaggt gcagcgcatc cggcacgagt tccgggatga tctggatgag     2520

cagatccgtc acatgctctt ctcctgggct gagcgccagg ctgggcagcc aggggctgtg     2580

gggctcctgg tgcaggccct ggagcagagt gaccggcagg acgtggctga agaggtgcgc     2640

gcagtcttgg agctcggccg ccgcaagtac caggacagca tccgacgcat gggcttggcc     2700

cccaaggacc ccgctctgcc tggctcctcg gctccacagc ccccagagcc tgcccaggcc     2760

taggccccac agacttttag gctggcccag atattcccca gtggatgggc agagccccca     2820

ccttcaagtc tctccagtgt gtggggacgg gtccctgtga gcaacaaaac tgcactgttt     2880

ctttca                                                                2886


<210> 2708
<211> 2390
<212> DNA
<213> Homo sapiens

<400> 2708
ttcgcggtgc caccgccccg cccacgcctc ctcgccggcc tccgagtgcg tcacgtgacg       60

ggtcggtggc gctggcggtt gctgtcagct gattcccggg gttggtggca gcggcggtag      120

cagcaatgga ctttctcctg gggaacccgt tcagctctcc agtgggacag cgcatcgaga      180

aagccacaga tggctccctg cagagcgagg actgggccct caacatggag atctgcgaca      240

tcatcaacga gacggaggaa ggtcccaaag atgccctccg agcagtaaag aagagaatcg      300

tggggaataa gaacttccac gaggtgatgc tggctctcac agtcttagaa acctgtgtca      360

agaactgcgg gcaccgcttc cacgtgctgg tggccagcca ggacttcgtg gagagtgtgc      420

tggtgaggac catcctgccc aagaacaacc cacccaccat cgtgcatgac aaagtgctca      480

acctcatcca gtcctgggct gacgcgttcc gcagctcgcc cgatctgaca ggtgtggtca      540

ccatctatga ggacctgcgg aggaaaggcc tggagttccc catgactgac ctggacatgc      600

tgtcacccat ccacacaccc cagaggaccg tgttcaactc agagacacaa tcaggacagg      660

attctgtggg cactgactcc agccagcaag aggactctgg ccagcatgct gcccctctgc      720

ccgccccgcc catactctcc ggtgacacgc ccatagcacc aaccccggaa cagattggga      780

agctgcgcag tgagctggag atggtgagtg ggaacgtgag ggtgatgtcg gagatgctga      840

cggagctggt gcccacccag gccgagcccg cagacctgga gctgctgcag gagctcaacc      900

gcacgtgccg agccatgcag cagcgggtcc tggagctcat ccctcagatc gccaatgagc      960

agctgacaga ggagctgctc atcgtcaatg acaatctcaa caatgtgttc ctgcgccatg     1020

aacggtttga acggttccga acaggccaga ccaccaaggc cccaagtgag gccgagccgg     1080

cagctgacct gatcgacatg ggccctgacc cagcagccac cggcaacctc tcatcccagc     1140

tggcaggaat gaacctgggc tccagcagtg tgagagctgg cctgcagtct ctggaggcct     1200

ctggtcgact ggaagatgag tttgacatgt ttgcgctgac acggggcagc tcactggctg     1260

accaacggaa agaggtaaaa tacgaagccc cccaagcaac agacggcctg gctggagccc     1320

tggacgcccg gcagcagagc actggcgcga tcccagtcac ccaggcctgc ctcatggagg     1380

acatcgagca gtggctgtcc actgacgtgg gtaatgatgc ggaagagcct aagggggtca     1440

ccagcgaagg taaatttgac aaattcctgg aagaacgggc caaagccgcg gaccgattgc     1500

ccaacctctc cagcccctca gctgaggggc ccccgggtcc cccatctggc ccagcgcccc     1560

ggaagaagac ccaggagaaa gatgatgaca tgctgtttgc cttatgagtg tggggtctgg     1620

caccctgcag cccaggtccc cactgctctc acacccttag gctgggacct ccctccctcc     1680

tctggtgtta aggctgcttt gggggtggct tgttaccccc ttttcctcct ctttgaagac     1740

ggagctgccc cagctgtggc tgggggtgtg gaggcagtgg gatgaactgg gggacaggtc     1800

tgcgctgcag tgggatctgg ctgctctgcc tcctttccca ccccagctga ccatgagact     1860

ttgctgagaa gtggaggccc caggacaggc tggctggctg gctggctgct tgacccagtg     1920

tgactctcct tcactgagtg ataccctgct ccgggcccat gccccaagga gcccttcaga     1980

gcccacactg ccagtcgagg cctggctgga ggctggccac agtggaaatt ctgccgagcc     2040

tcttgtccct tccctgctct gctgcatggg gccccatggc tttggctggc cactgagggt     2100

agggtgtgga ggtgtggagg ccccctgagg agctgcggcg gcccaggtac gaagctgcaa     2160

ctctgcgcgc agtgggcgag atctcatcag ccccaggctg caggtgaggc ttcaggggat     2220

gctggggccc cactgcccct ccgctgcctt gccctccatc cttcctctgt tccttctggc     2280

cgggcaccac agcactgggg ctcacctctt ggttgatcct cttgtactgg gagaggtgcc     2340

ttttgtatcc ccaattaaag gtagaaaacc accctgctag cagcattgtc                2390


<210> 2709
<211> 1122
<212> DNA
<213> Homo sapiens

<400> 2709
gttggatgct ctgctcgttg agtgaagaaa atccaccggc atcgcctgag ccccgctacc       60

gagaagggcg ccgcttcctc cggggagggg gataaagatc ccccgccgcc ggcccatgag      120

gatattgccg tgaaaggcac agcgactgca gcaggaaccg gacccggcac cggagcggcg      180

gcggcggcgg cagcagcggt accgcctcct cacccggcgg cggcagcagc ggcggcggcg      240

gcggcggcgg cggcggcggc ggcagcggtc ccccctcctc acccgaacat cagggccctc      300

cagactcagg cgccccaaca aattcctaga ggacctgtgc aacaacctct tgaggatcga      360

atcttcactc ccgctgtctc agcagtctac agcacgaccc cttatccctc tggacagaat      420

gcaggtccaa ccacgctggt ataccctcaa acccctcaga caatgaattc acaacctcaa      480

acccgttctc cgcccagcag aacagtgcca atacattgca cagacaactg gaagaggagg      540

aaggttttgg aacagactcc cgtttacagg tccttggctg gaagaggctg gataaaatac      600

tgcatttttt tccagaggcc tcaaatacag cctcctagag ctaccatccc gaacagcagt      660

ccttccattc gtcctggtgc acagacaccc actgcagtgt accaggctaa tcagcacatc      720

atgatggtta accatctgcc catgccgtac ccagtgcccc aggggcctca gtactgtata      780

ccacagtacc gtcatagtgg ccctccttat gttgggcccc cccaacaata tccagttcaa      840

ccaccggggc caggtccttt ttatcctgga ccaggacctg gggacttccc caatgcttat      900

ggaacgcctt tttacccaag tcagccggtg tatcagtcag cacctatcat agtgcctacg      960

cagcaacagc cgcctccagc caagagagag aaaaaaacta taagaattcg ggatccaaac     1020

cagggaggta aagacataac agaggagatt atgtctggag gtggcagcag aaatcctact     1080

ccacccatag gaagacccac gtccacacct actcctcctc ag                        1122


<210> 2710
<211> 588
<212> DNA
<213> Homo sapiens

<400> 2710
gggatgctgg ggcgcgagcg ggactgttga ctaagcttcg ttactgggcc ctggaagcga       60

ggtgccaccg tacaggcagt acttctccag gcaagtagta ttaaacacca gccgccctgg      120

gccaggcatt gtactgtggg acccagtatg cattaaggga agaatccagg ttcaaaatga      180

gcctgtttgg aacaacctca ggttttggaa ccagtgggac cagcatgttt ggcagtgcaa      240

ctacagacaa tcacaatccc atgaaggata ttgaagtaac atcatctcct gatgatagca      300

ttggttgtct gtcttttagc ccaccaacct tgccggggaa ctttcttatt gcaggatcat      360

gggctaatga tgttcgctgc tgggaagttc aagacagtgg acagaccatt ccaaaagccc      420

agcagatgca cactgggcct gtgcttgatg tctgctggag tgacgatggg agcaaagtgt      480

ttacggcatc gtgtgataaa actgccaaaa tgtgggacct cagcagtaac caagcgatac      540

agatcgcaca gcatgatgct cctgttaaaa ccatccattg gatcaaag                   588


<210> 2711
<211> 8047
<212> DNA
<213> Homo sapiens

<400> 2711
gacggcggct cggcgatggc tctcccgcag gcgcagaaac ggctgctggg cagctgatgg       60

gcaggagctt accaggctgg cttgctctga gctgcggtta ctgtgtccag gccccgggtt      120

ctcagaactg tcatacataa agtacacaga aatgaagaga aaagtcgtga atactcacaa      180

gctgagattg agtcctaatg aggaagcctt cattttgaag gaagattatg aaagaaggcg      240

aaaactaaga ttgctacagg ttcgagaaca agaaagagat atcgccttac agataagaga      300

agacataaaa cagaggagaa atcaacaatt tacacgtttg gcagaggagc taagggcaga      360

atgggaagaa tcacaaactc agaaaataca gaacttggaa aaactgtatt tggcaagttt      420

aagaagtatg ggagagggac atcgacaggc caaagaaaat gaacctgatt tggatgcttt      480

ggcacagcgg gcagcagaaa ggaaaagaaa agcagatttg aggcataaag aagccttgaa      540

agtacagaaa aatcaaaaag aaatattact gaaacaaaaa acctggcata taaaagctcg      600

aaaggaagca ctgcttgtgg aaaaagagag atcagccaaa attacaagtc tgccacctcc      660

tcctccaact ctttttgaga acatcgaagt aaaaagaatt tctgcagtca aaaccaatag      720

ttctacctac catcatcttc acacttttgt gaatagagag acagacacaa aacggccaga      780

tgctcgtttg gctgctgaag aggaagctaa acgattggaa gaactacaaa aacaggcagc      840

acaagagaga atggaacggt ttgaaaaggc acatgtacgg ggattccaag caatgaagaa      900

gatccatttg gctcaaaatc aggagaaact aatgaaagaa ctcaaacagc tacagcaaga      960

ggacctggca cgtaggagac agactgtagc acaaatgcca ccacaactag ttgaacttcc     1020

atacaaacgc agtgaaatga aagaagactg gcagagagaa ttggaatttg cctttgaaga     1080

tatgtacaat gcagacagga aggtgaaagg gaatctgatt ctgcaccttg aaccagagcc     1140

cttgcccact gtgactaatc agatccaaga tgaagagctg gacctttcaa tggaacaaga     1200

aaatttgggt gcagctgaag accttccagt gacagaagct gaaatatgtt ctagtgaaac     1260

agatgttccc ttggtaatga agacccaaca gattccttca aaagttcttt ttaaaaaatt     1320

attaaataag atccgaagcc aaaaatctct ctggacaatt aaatctatgt ctgaggatga     1380

aagtgaaatg attacgactg ttagtgaaat tgagagtaaa gcaccaacgg ttgagtcagg     1440

aacaattgcc agcaaagaga gaacgttatc ctctgggcag gaacaagttg ttgaaagtga     1500

tacactaaca attgagtctg gaccacttgc tagtgaagat aaaccacttt cgtgtggtac     1560

aaactctgga aaagaacaag aaataaatga gactctgcct atcacaactg tagctcagag     1620

ttcagttcta cttcatcctc aagaagcagc agccaggatt agaatgtcag caaggcagaa     1680

acagataatg gaaatagaag agcagaagca aaagcaattg gaattacttg aacaaattga     1740

acagcagaaa ttaagattag aaactgactg cttcagggct cagctggaag aagaaaaaag     1800

aaaaaaaact caaccgactg gggttggcat tgctccagca tcatgccctg taatttctga     1860

tgaagatagt cataggcaga tgattcgtaa ctatcaacat cagcttttac aacaaaacag     1920

gttacacagg cagtctgttg aaacagccag gaaacaatta cttgaatatc aaactatgtt     1980

aaaaggaagg tgcccatcgg tgtcagctcc atcattgata actgattctg ttatatcagt     2040

gccatcatgg aaatctgaga gaccgactgc tatatcagag cattgggatc aaggtcagag     2100

actcaagttg agtcctaaca aataccaacc catacaacct atacagacct ccaaattaga     2160

acaagatcat tttcaggtag cgagacaaaa tcactttcca caaagacagg tggaaacaac     2220

agaaacatta cgcgcttcag atattttaac caatcaagct ttagaatcac aagaacatct     2280

aaggcaattc tctcagactg aaacacaaca gagagactat aaattggtcc ccaaagattc     2340

tgagacactt tcaagggctt tgtcacatga caggcagcta atatcacagg atgctagaaa     2400

aatatctgaa acatttgggg caacaacttt tcaaagttta gaatcccaac aattgttctc     2460

agagaatagt gaaaatatat cttaccattt aactgaacct tcttcatttg taccactggt     2520

acctcagcat tcttttagtt ctctgcctgt taaagttgag tcaggaaaaa ttcaagaacc     2580

cttttcagcc atgagcaaaa gtacagtttc cacaagccat tctataatca gccaaatgca     2640

tgataggcct ttgctgccgt cagagaatat cacagcccag caaggtaata tgaaggccct     2700

ccaagaacag ttagacctac agaagaaagt tcttcaggca actcaggaag ctcaggaaca     2760

gttgcttttg tgcaaacaga aagaagtgga acagcaaacg ggcctctcgg tattccttcc     2820

cttggtaact ccagattcat ctgctttatt gccttctgcc aaagcagatt tggggagaat     2880

ccaggaatct tcaccaacca agaataatat tgcagtttcc tcagaccatc atgtgatctc     2940

acaacttcag gataagcgtt tgagtctttc acagcctatc ctatcacagc aaaataattt     3000

taaatttctc caagagcagt tgaatattca gaaggatagc cttcaggcta ggcgagaagc     3060

ccaggaagta ttgtatgtac ataaacagag tgaattggat agaagagtat gttccgaaca     3120

ggctgagccc tctttcccat ttcaggtagc tcagcataca tttacttcac taccatctgc     3180

tgatacaaaa tctggaaaaa tacaggagca acattcatct aagagcgaga aaggacttgt     3240

ttcatgccaa tctgacatcc ccatatctca ggatgggtct ttgagtttcc tacagcagtt     3300

cctacctcta catgatagtt tgaagttgct ccaagaacag ttgactaaac agagggatac     3360

tcttcaggct aggcatgaag ctcaggtgga attactttta catagacaaa gagatttggg     3420

ggacagtaag tctgggctgg tgagctcttc atcctcacca gtggttgttc agcattcagt     3480

tgcttcacaa gcttctgcta aagctgagcc taggagaatt caggagcttt atttatctga     3540

gaaggagaat gtaggtccct cctgtcattt gataatccca acatttcagg ataagtctct     3600

tagttttcca cagcatagcc tggcacagca agaaaatttg acaatactcc aagaacagtc     3660

acaaatacaa agggtaatac ttggtgctaa agaaggaact caggaatttg tacacacaga     3720

aagtgaattg gagaaaagaa tttcttctga acagactggc acctcctcat ccctttccca     3780

ggtggatgaa tctgagagat tccaggaatg tatatcaatc aagagtgaca gtaccattcc     3840

cttaagccat cctaagatcc caagatgtca ggaaagactt ttgagagttt cacaacatat     3900

gctacctcta caagataatt tggaggaaca ccaagcatgg ctagacactg agaaagaagc     3960

ctttcatttc agccagaaaa cccaagaaaa tacatcttct gaacaaactg gttcatcttc     4020

attcataccc cagttggtac agctttcatt tacttcgtta gcttcagctg agtctggcac     4080

aatcctggaa cctcttttta cagagagtga aagtaaaatt ttttcaagcc accttcagat     4140

cccacaattg caggataggc ttttgaggat atcgcaactt atccagcctc aacaagataa     4200

tttgaaggca cttcaagaac agttagctac acagagagaa gccatcattc tagctagaca     4260

agaagctcgg gaagaattac ttttacatca gagtgaatgg gagggaagaa tatctcccga     4320

gcaggttgac acctcttcct tacccctagt accacagcat tcattcgcct cattacctct     4380

taatgaatct gaaagaaacc aagaaccatg ttcaattaac agtgataata tagtatcctc     4440

aggtcactca gagataccaa cattgcctga tgggctgttg ggtttatcac atcttgtttt     4500

acctcaacaa gataatttga ttgcacttga agaacacttg catgcacaga cagatttcct     4560

tccttctatt gagaaaaccc agaaagaatt ggttttgtca aaaccatgta aatttgagga     4620

aaaggtatct tctgagcatt ttatccagtc tcaccatggt gatttgcagg cacttcaaca     4680

gcagttagat acacagaaga aagccattcg atctatacag gaagtccaag aagaattgct     4740

tttgcaaaga ttaagtgaat tggagaaaag ggtatcatct gaacaagttt gctcctcttc     4800

atttgtatcc caggtgcctg ttgctgactc tgaaagaacc cagaagtctt tcccaaccaa     4860

aagtaatgat actcttccct caagtcatcg tgagattcca agattacagg atagactttt     4920

gagtttatca aagcctattc tgcctcagca agataatatg acagcacaat tggatgcaca     4980

aagggaagtg atgtattctt atgagaaacc ccaggaagaa ctgtctttaa acaaacaaag     5040

aaagttgaac aaaagtgaat ctgctgagca tactatcccc tctttgtttc tacccaagga     5100

aacagagcat tcgtttattc cactaccttt tgcagaagct aaacctaaaa gcacttgtga     5160

attgtattca tcccagaatg aacatgcagc ccccccaagt aatcctgtga tcccagggtt     5220

tcaagataga cttttgagtt tttcacagtc tgtcttaact cagcaagata acttgggact     5280

tcagaaacag ttggatctac aaagagaagt tctgcattat agccagaaag cccaggaaaa     5340

attgcttgta cagagacaaa cagcattgca gcagcagata cagaaacatg aagagacttt     5400

gaaggatttc tttaaagaca gtcagataag taagcccaca gttgaaaatg atttaaaaac     5460

ccagaagatg gggcagctca gagactggtt tcctaataca caagacctag caggaaatga     5520

tcaagaaaat attaggcatg cagataggaa caactctgat gataatcatt tggcttcaga     5580

agatactagt gccaagcaaa gtggtgagca tctggagaaa gatctgggga gaagatcctc     5640

aaagccacct gtagcaaaag tcaaatgtgg tttggactta aaccagcatg aacttagtgc     5700

tatacaagaa gtagagtcac cagcaattgg cagaacttct atactaggta aaccaggtat     5760

ttatgaagac agagaccccc tgcgagtctc aataagccga gaacaaagtt tctttgggag     5820

cccactggcc catgatccgt ttagttgtct tcaactggtt ggccaagaga atgtctgtgg     5880

tgatgactat gatgaagcag ttaagctgaa ggaatctgtt gttgaaaatc atgcagtgtt     5940

aagttatgct gtggaggaag aacatgcata tttgggtcca actgtgaagc cagatgataa     6000

ggctaaaaca ctgtcttatg aaccattatc ttcagcaact gtttccactg ggagcctttt     6060

aagttatgaa aacacagatt tgagccttac agatccagag tcattttcag agcacatgga     6120

tgatagcaag caagaatcta ccaccagtaa agaagaggaa acaaatatta taagttccat     6180

agttccttca acacaagata tttatcagcg gcagaactct tcagacgttc ataaatctct     6240

gttgcctgca gtggatgaaa ctacatgtgg tcacacacac tttcagcaaa tgatagacaa     6300

gtacattaat gaagcaaatt tgatacctga aaaaacagat ttgcaagaat tggaacacat     6360

ttttcctaat ttgcatcatc agctgtttaa acccttagaa ccacatccag attttgactt     6420

atcatcatca tcctctggga tttctccaga caacagagac ttttaccaga gatcagattc     6480

ttcatctgaa agccactgtg ctactggatt atccaaaagt acagtttatt tcacagcact     6540

gaggaggacc agcatgcatt cttctcttaa cacaagtccg aatcaacaac ctgacactaa     6600

cttggctcat gttggagctc acagttttgc tacagaaaat attattgggg gatctgaaca     6660

atgttttgaa cagcttcagc cagaatattc ttcacaggag gagagccagc atgctgatct     6720

accaagtatt tttagcattg aagcaagaga ttcttcccaa ggcatgaaaa atcagaacta     6780

tccctctgaa gaacatactg aaatattaca aaacaagaaa aaaattgttc atttccagct     6840

ttctatagga aacttaagtt cagtctacag ttcatctgat gaagctaatg tatttgatca     6900

gttaaatgta cagcatagca ctccatgtgg ttctaactct agtgagtgct caacaaaaca     6960

ccaactagaa agcagaaagg aaagtatggg ctttgaagaa ctatcaaaaa gaggggttgt     7020

tacaatgtta caaagtcaag gactcattga agataataaa aatgaaacct gtagggtttt     7080

agacataaat ccacaggtag aggaaactga ctctcgatta tgtgtaagaa cagtggagat     7140

gggaacttca attcaggcac catattcctt aactactcaa aatgaaaaat attttgagaa     7200

ttcagctgaa acagacattc caaaaatcac caaaaaacta tctcaactag gagaatcaga     7260

gctttttgca agttctggat cattttcatt acagagctct ataccagtct gggaaacaga     7320

aactggccat ggtataatgg aagaaccaga acttacttta ataagcacca ctgataccag     7380

tattgctgaa atggattttg caaatttaac cctagaagag aagagcgaga atgaagcaaa     7440

atgcttcttt caggtgagtg agtttctgcc tcttgtatca gcaacagaag cctcagatta     7500

tccagctgta tcagaacttt ccatagaaaa accaaggaca gcatctacag cagaaacccc     7560

tcgcaggctt acacctgtac cagggagctt acaagaagca tttataaaga ggaaaaaatc     7620

atttatggag agatcccacc agaggcagaa agaaataagg aataaaattc atgtctctga     7680

aaattctcaa atcaaaacag ttaaagagaa accatctata agttcatctg tgagtcgtct     7740

aaagggcgtg aataaagtca gagcatcttt tcctgaagac agaaagacta cacaggctct     7800

aaggcaccaa aggggtctaa ggttatacaa tcaactagct gaagtgaaac aacaaaagga     7860

agaaaaaaca aaacaagaag cttatgccca aaacagagca agggcaaaag aattccataa     7920

gaaaacacta gagaaacttc gagccaaaaa tacatgctga ctttctagaa atagtgtaaa     7980

ggttttttaa ttgtgtatat gtagcattag acaaaattat ttaaagtcaa taaattgtta     8040

ttcgagg                                                               8047


<210> 2712
<211> 1602
<212> DNA
<213> Homo sapiens

<400> 2712
tcagctcctt cagtaggcaa tgatatggga aatgatgatg ccattggagg gaatgtgagc       60

aaatatatag tgcttccaac tggctattgt ggacagccca agaaaggaca tcttatcttt      120

gatgcttgct ttgaaagtgg taacctgggc cgggtggacc aggtctctga gtttgagtat      180

gatctgttca ttaggccgga cacctgtaat ccacgcttcc gagtctggtt caactttact      240

gttgaaaatg tgaaagaatc acagagggtc attttcaaca ttgttaactt cagtaaaacc      300

aagagtctct atagagatgg gatggcccct atggtgaaat ctaccagcag accaaaatgg      360

caaaggctgc cacccaaaaa tgtttactac taccgctgcc cggaccatag gaagaactat      420

gtgatgtcct ttgccttttg ttttgaccga gaagaagata tttaccagtt tgcttactgc      480

tacccatata catacactcg cttccaacat taccttgaca gcctgcaaaa gagaaacatg      540

gattacttct ttcgggagca gctgggccag agtgtgcaac aacgaaagct tgacctcctg      600

acgataacca gccctgacaa tctccgggaa ggggcagagc agaaggtggt attcatcaca      660

ggacgagtcc acccagggga aacaccctca tcatttgtgt gccaagggat cattgacttc      720

cttgtaagcc agcaccctat tgcctgtgtc ctccgggaat acctggtctt caagatcgca      780

ccaatgctca atcctgatgg agtctacctg ggcaattaca ggtgttctct gatgggattt      840

gatctgaatc gtcactggct ggatccctct ccatgggtcc atcctaccct gcatggagtg      900

aaacaactca tcgtccagat gtacaacgac ccaaaaacaa gcctggagtt ttatattgac      960

atccatgccc actccaccat gatgaatggc ttcatgtatg gcaacatctt tgaggatgag     1020

gaacggttcc agaggcaggc catttttccc aagctcctct gccagaatgc tgaggacttc     1080

tcctattcca gcacatcctt taaccgggac gctgtgaaag caggaactgg ccgtcgcttc     1140

ctcggtggac tcctggacca cacttcctat tgctacaccc tagaggtctc cttctacagc     1200

tacatcatca gtggcaccac ggctgctgtg ccctacactg aagaagccta tatgaagctg     1260

gggcggaatg tggcaagaac ctttttggac tattatcggc tgaaccccgt ggttgaaaag     1320

gtggcaattc ccatgccgag actgcgaaat aaagaaatag aagtccagag aaggaaagaa     1380

aaatcccctc cttacaagca cccactcctg cggggcccag ccagcaacta ccccaacagc     1440

aaaggggaca agaagagctc agtgaaccac aaagaccctt caaccccttt taagacacgg     1500

agtcctggga ggtcttatgg ggacaggagc atgcattttc tgctggggaa tgaaattaat     1560

cactcttctc tagcttccaa ggatttgtgg attaatgcat ag                        1602


<210> 2713
<211> 1832
<212> DNA
<213> Homo sapiens

<400> 2713
tggttgcgcc tgcgcagtgc atcaccgcag gcgggcctcg cgggtccggg agcgcggcgg       60

agacgatgcc tgagatcaga gtcacgccct tgggtgcctg ccctgtgctg tcctggaacc      120

tggtccttcc accgggcagg gggtcgaggg caccttccag cacagacacc aggacgggat      180

tccatgtcct cccccatggc gtagatgatg agctggagat caaggcctac tatgcaggcc      240

acgtgctggg ggcagccatg ttccagatta aagtgggctc agagtctgtg gtctacacgg      300

gtgattataa catgacccca gaccgacact taggagctgc ctggattgac aagtgccgcc      360

ccaacctgct catcacagag tccacgtacg ccacgaccat ccgtgactcc aagcgctgcc      420

gggagcgaga cttcctgaag aaagtccacg agaccgtgga gcgtggtggg aaggtgctga      480

tacctgtgtt cgcgctgggc cgcgcccagg agctctgcat cctcctggag accttctggg      540

agcgcatgaa cctgaaggtg cccatctact tctccacggg gctgaccgag aaggccaacc      600

actactacaa gctgttcatc ccctggacca accagaagat ccgcaagact ttcgtgcaga      660

ggaacatgtt tgagttcaag cacatcaagg ccttcgaccg ggcttttgct gacaacccag      720

gaccgatggt tgtgtttgcc acgccaggaa tgctgcacgc tgggcagtcc ctgcagatct      780

tccggaaatg ggccggaaac gaaaagaaca tggtcatcat gcccggctac tgcgtgcagg      840

gcaccgtcgg ccacaagatc ctcagcgggc agcggaagct cgagatggag gggcggcagg      900

tgctggaggt caagatgcag gtggagtaca tgtcattcag cgcacacgcg gacgccaagg      960

gcatcatgca gctggtgggc caggcagagc cggagagcgt gctgctggtg catggcgagg     1020

ccaagaagat ggagttcctg aagcagaaga tcgagcagga gctccgggtc aactgctaca     1080

tgccggccaa tggcgagacg gtgacgctgc ccacaagccc cagcatcccc gtaggcatct     1140

cgctggggct gctgaagcgg gagatggcgc aggggctgct ccctgaggcc aagaagcctc     1200

ggctcctgca cggcaccctg atcatgaagg acagcaactt ccggctggtg tcctcagagc     1260

aagccctcaa agagctgggt ctggctgagc accagctgcg cttcacctgc cgcgtgcacc     1320

tgcatgacac acgcaaggag caggagacgg cattgcgcgt ctacagccac ctcaagagcg     1380

tcctgaagga ccactgtgtg cagcacctcc cagacggctc tgtgactgtg gagtccgtcc     1440

tcctccaggc cgccgcccct tctgaggacc caggcaccaa ggtgctgctg gtctcctgga     1500

cctaccagga cgaggagctg gggagcttcc tcacatctct gctgaagaag ggcctccccc     1560

aggcccccag ctgaggccgg caactcaccc agccgccacc tctgccctct cccagctgga     1620

cagaccctgg gcctgcactt caggactgtg ggtgccctgg gtgaacagac cctgcaggtc     1680

ccatccctgg ggacagaggc cttgtgtcac ctgcctgccc aggcagctgt ttgcagctga     1740

agaaacaaac tggtctccag gctgtcttgc ctttattcct ggttagggca ggtggtccta     1800

gacagcagtt tccagtaaaa gctgaacaaa ag                                   1832


<210> 2714
<211> 2253
<212> DNA
<213> Homo sapiens

<400> 2714
gacttttgtt tttcagttgc gttccctgac tcggagtctt agtgtgtcgt tatttggaca       60

agaggcacat tgacccaatt tggagacgta ttttggaagg aggcgaacag ttgtctccaa      120

acgtggtgtt gccgtcagtg gtcccaccaa gaggagggga atggcagatt cactggagtc      180

aacccccttg ccttcccccg aagatcgtct ggccaaactc catccttcta aggagctcct      240

ggaatattat caaaagaaga tggctgagtg tgaggcagaa aatgaggact tgctgaagaa      300

actggaactc tacaaagaag cttgtgaagg acagcataaa cttgaatgtg atttgcagca      360

gagggaggaa gagattgctg aattgcagaa agctctaagt gatatgcagg tctgcctctt      420

ccaggaacgg gaacatgttt tacgcctcta ctcagaaaat gaccgactga gaatcaggga      480

gctagaagac aagaaaaaga ttcagaatct cttggctctt gtgggaacag atgctggaga      540

agtgacctat ttttgtaagg agcctcctca caaagtcacc attctccaaa agactatcca      600

ggctgtaggt gaatgtgagc agagtgaatc ttcagctttc aaagcagatc ctaaaataag      660

caaaagaaga ccatcgagag agagaaaaga aagttctgag cattaccaaa gagacataca      720

gacactcatc ctacaggtgg aagcactgca ggctcagctg ggagagcaga ccaaactttc      780

tcgagaacaa attgaagggc tcatcgagga cagacggatt caccttgagg aaatacaagt      840

tcagcaccag agaaatcaga acaaaatcaa agagctaacc aaaaatcttc accacaccca      900

agaactgctc tatgagagca ccaaagattt tctgcaactc agatctgaaa accaaaataa      960

agagaagtca tggatgcttg aaaaagataa tttgatgtca aagattaagc aatatagggt     1020

gcagtgtaag aagaaagaag ataaaattgg aaaagtgttg cccgttatgc atgagagtca     1080

ccatgctcaa agtgaatata ttaagtccct aaaagataag ttagtacaag agaaaaagct     1140

gtccaatatg taccaagagc agtgcatttc cttagaagaa gaacttgccc gaattcgtga     1200

ggaagaggga atgaggagag agatcttcaa ggatcgcact aacaagatgg ggaagcgttt     1260

acagataatg acaaaacgct atgaggcatt ggagcgtcga cgtatcctgg aagtagaagg     1320

ctttaagaca gatattaaag ttctccgaca gaaactgaaa gacttggagc aaatgttgta     1380

taaggcaaca gttaatgccc gggcaaacca ggatcttgcc cttctgtgtg aggtccgtga     1440

cagcaataga cgggcacata agatacaagg agaactgaag aatcttaagt cgaaagtgtt     1500

tggtctggag aatgaactta gactctgtta atgtctactt ttggaaatgg cccccattta     1560

gaagaggtgt gcttcttgaa acctgaggac aaggtcatct gctgccagaa aatgtaaacc     1620

tgagttgact agagtggtgg tattcattat tgtaaagaca gcttgaagaa tcggggacca     1680

ctaggaaagc ttttcttgca tactcagctt gctttatcat ttttgctgtc cttttaacac     1740

ttgcgaggag taggggcctg gtcctgaatg acttggaggc tttcattatt tatcctgtct     1800

gtattgaccg gtttttgttt tttcagaagg cagtgatgat gaaaacttag gaagaaggta     1860

ttttgcaata agcttggctg agtgtccatg ggaagaatac tttccctaaa gagagagaag     1920

cactcacaga ggctgccttt ctcctgagct cggggagaag gcagcacatc acaacctgtc     1980

acattgaaat aggcgctcat tctgctattt caccttccgt cctgagcaga gcctgaatta     2040

cgtttttggg caatttcatg gtgtttcacc agagggcgct agagactcaa acgaaatgtc     2100

catctggaaa gattcgggag acactttgcc gaggggatga agctgagatg atgcttgtat     2160

ggaaagtttg atatttttat cagtcacatg gcttttgaaa aatgatgtat atattttaaa     2220

ttaactattt tcaataaaat atttcactca aaa                                  2253


<210> 2715
<211> 2506
<212> DNA
<213> Homo sapiens

<400> 2715
attagagaag aagcaggcag cttgagacag gtggagctgg atcaagctgt gaacgtgatt       60

tgctggaagc tggtcattag tgttagaaac cccgtcttat ttatttcatc cttcacccta      120

ccatgattat tgcaattatt attatttatt tttcatcttt tttcaggttg acgatgtgtc      180

acactgtgta agggaatcgc atggagatgg gcattccgaa ctgttaatgg ggacatggga      240

ctccagttgt ctctgatcac ttgtgtggat tttcctggcg tagaacgaca gaagccgcta      300

gtaagtcgcc aagacctaca gcaggaattc tgcaccaaag ggcataaaat cttgttattt      360

taatttgcat ctgggagaat gtctgagcaa ggagacctga atcaggcaat agcagaggaa      420

ggagggactg agcaggagac ggccactcca gagaacggca ttgttaaatc agaaagtctg      480

gatgaagagg agaaactgga actgcagagg cggctggagg ctcagaatca agaaagaaga      540

aaatccaagt caggagcagg aaaaggtaaa ctgactcgca gccttgctgt ctgtgaggaa      600

tcttctgcca gaccaggagg tgaaagtctt caggatcaga ctctctgaaa actgcaaatg      660

gaaaggaatt caaaagaatt tagattaaaa gttaaataaa aagtaggcac agtagtgctg      720

aattttcctc aaaggctctc ttttgataag gctgaaccaa atataatccc aagtatcctc      780

tctccttcct tgttggagat gtcttacctc tcagctcccc aaaatgcact tgcctataag      840

aaacacaatt gctggttcat atgaaactta ggaaatagtg aataaggtgc atttaacttt      900

ggagaaatac ttttatggct ttggtggaga tttctcaata ctgcaaaagt tgtccagaaa      960

tgaatctgag ctgatggtga ctttaagtta atattattaa tatatcactg catattttta     1020

cccttatttt tgctccttac agcaagatta gtaggttata aaaatttaaa tttaaacaaa     1080

attatttcat gacaaaatgg gaaacttcac atcatactta tttttgtttg cctttcaggc     1140

atcatattag cttttataaa aaatggtctt gctgctgaaa ttgtacttat tttatcagag     1200

gctgggtgca gtcaagacaa aagtaaaatg gtttacctga gcccagggga gggaaaattg     1260

attaagatat cattattttt gtttggtttg gttttgcttt tttcctctta ctttaattga     1320

aatactctga attcccctca tggaaacaga gagcattgag agcactttct ttaaaaggac     1380

caaaaataaa ttcctaatag attttgtcct aagagagtgt ttttttttct agcatcattt     1440

tctttacatg ccactcatgt cataaggcat ggacaggcta tctttcagtg gccattacta     1500

tgtttcgtac acatgcttta ttttacttgg gctctgagaa atgtgtggct ttccttcagc     1560

attttatttg tgcttctctt tttaatggag attgaaaagg gagaataatg tgaatatcac     1620

ggcttatatt attaaatgtt gattgatggc ttgtaatgta ctgcacacaa tatatgttaa     1680

ctctgcagaa tgacagaccc tgggagaagt aatgccccag ttgtccccca ctcctaatgc     1740

caggcagaga aggacagcct ttatagactt aatctgcttt ttgtcccatt tgacaaggta     1800

ccaggaggaa attttttaag ggatcaactg tatcacagtg cccactctgg acctaagtct     1860

agtgtatcca tacaattggt gcagagaaat aaggtgtaaa tggtgctttg ttcctgctgg     1920

ttccaagctc agaaaccaag actagctttg taggagagaa tgagagcctg caagcctctc     1980

tttggattgg ctgaggagtg gtgggagcag ggggttgata gaaaacatcc agacacacat     2040

ataagcaagt ggccgtgcta cctttttaga gaataaagaa acagactttt gagtttatat     2100

gcaatgcctt cattaggtac caccggcact tacaaaatgt gcggactgaa tcccagagaa     2160

cactggcaga tgtatacagt atatggattg tatcgcttcc ccaatgtttg taaattcaca     2220

gtatttggaa aactgccttc attttccagt gtgggaaaaa ctcttgctac ctgtattact     2280

tgatctcaga cccatacctg atggttcagt ctgtccttaa gttaaaagaa ttttgctttt     2340

ctaatgttat actatttacc tgtcagtgta ttactgcaac ttgaatcact cttttactgt     2400

tgttggatat aaacttatcc tgtaccaatg tatttattaa cacttgtatt ttattattga     2460

gcatatcaat aaaaatatta aaaaataaca gattgttttt taccaa                    2506


<210> 2716
<211> 1090
<212> DNA
<213> Homo sapiens

<400> 2716
aacaaagggc cgcgggcggc gggcagtggt gtcccagtct cccggtgctt ccctgaggct       60

gaggcgcccg gcctcccgcc cgccgcgctc cagatgaagt gtgagcactg cacgcgcaag      120

gaatgtagta agaaaacaaa aactgatgac caagagaatg tgtcagccga tgcaccgagt      180

ccagcccagg aaaatggaga gaagggagaa ttccacaagt tggctgatgc caagatattt      240

ttgagcgact gcctggcatg tgacagctgt atgactgcag aggaaggagt ccaactttcc      300

cagcaaaatg ccaaggactt cttccgcgtt ctgaacctta acaagaaatg tgatacctca      360

aagcacaaag tgctggtagt gtctgtgtgt cctcaatctt tgccttattt tgctgctaaa      420

ttcaacctca gtgtaactga tgcatccaga agactctgtg gtttcctcaa aagtcttggg      480

atgctcccat ttcccagtag cctccaggcc tgcaggttcc catgacccac agccgggcca      540

ccgaggacgg gttttgggtc cagcacgagc tcctggctgg gtccgatacg ccgagcgggt      600

gctgggtcgc cccatcactg cccacctctg caccgccaag tccccccagc aggtcatggg      660

ctctttggtg aaggattatt tcgccagaca gcagaacctg tctccagaga agattttcca      720

cgtcattgtg gccccttgtt atgacaagaa gctggaggct cttcaggaaa gccttccccc      780

tgctttgcat ggctcccggg gcgctgactg cgtgttaaca tcaggtgaaa ttgctcaaat      840

aatggagcaa ggtgacctct cagtgagaga tgctgccgtc gacactctgt aagtggcttc      900

tctggggaga gtcctctggg gggcaggacc tctcgtcagc cctgccagcc acctgccagg      960

cccagggctg ccctgcttta tgacgaggcc atgtgaagca ctgcgatgca gtcccccagg     1020

cccctgccac aaccctcagc caccctatag ctgttgaatg ggataccatt caccagggct     1080

gccagggagt                                                            1090


<210> 2717
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 2717
ctcacctgct cctctacctg ctccaccctc aatccaccag aaccatgggc tgctgtggct       60

gctccagagg ctgtggctcc ggctgtgggg gctgtggctc cagctgtggg ggttgtggct      120

ctggctgtgg gggctgtggc tccggccgtg ggggctgtgg ctctggctgt gggggctgca      180

gctccagctg tgggggatgt ggctccagat gttatgtgcc tgtctgctgc tgcaagcccg      240

tgtgctcctg ggtgccagcc tgttcctgca ccagctgtgg ctcctgtggg ggctccaagg      300

ggggctgtgg ctcctgtggg ggctccaagg ggggctgtgg ctcctgtggg ggttccaagg      360

ggggctgtgg ttcttgtggc tgctcccagt ccagctgttg taagccctgt tgctgctcct      420

caggctgtgg atcatcctgc tgccagtcca gctgctgcaa gccctgctgc tgccagtcca      480

gctgctgtgt ccccgtgtgc tgccagtcca gctgctgcaa gccctgttgc tgccagtcca      540

actgttgtgt ccctgtgtgc tgccagtgta agatctgagg ctctggaccc agaccttcag      600

gtttctcctg tttggtgaaa gcatttctta tggttccctg agtcagttcg tcccacacat      660

cctccctgag gcacctgcac ctgctctagc tcaccatcca tgcacacacc tccttccatg      720

gctcagctct cctctgggcc ctgccttcag cctcctcact ccagaaacgt gtgtttccct      780

gatgcgggag gtgtcctcgc ctggacgcag gcacccagcc gactgccacg atgttccctg      840

cacttgggtg tggaccatct tcttcttctc cctgggctga ctgagatgca aggtctgacc      900

ccacaaggcc aggccgacgt ttctgagtga tcactaagaa ccagcttctc aaccaccatc      960

aggaccctgg atcctcctgg gccgctgcct gttctcctgt ggcccaagtg tgaccaggaa     1020

ggtctctttc cttcctgttg tctccatctg tttaaaaaaa aataacaaaa taatgaatga     1080

atttccttgc aataaagcct ctcatgtctg taaatc                               1116


<210> 2718
<211> 682
<212> DNA
<213> Homo sapiens

<400> 2718
ctcaaccaca gactacactt gctgaactgg ctcctggggc catgaggctg tcactgccac       60

tgctgctgct gctgctggga gcctgggcca tcccaggggg cctcggggac agggcgccac      120

tcacagccac agccccacaa ctggatgatg aggagatgta ctcagcccac atgcccgctc      180

acctgcgctg tgatgcctgc agagctgtgg cttaccagct acggagttcg agaagtggac      240

caagtgaaac gtctcacagg cccaggactt agcgaggggc cagagccaag catcagcgtg      300

atggtcacag ggggcccctg gcctaccagg ctctccagga catgtttgca ctacttgggg      360

gagtttggag aagaccagat ctatgaagcc caccaacaag gccgaggggc tctggaggca      420

ttgctatgtg ggggacccca gggggcctgc tcagagaagg tgtcagccac aagagaagag      480

ctctagtcct ggactctacc ctcctctgaa agaagctggg gcttgctctg acggtctcca      540

ctcccgtctg caggcagcca ggagggcagg aagcccttgc tctgtgctgc catcctgcct      600

ccctcctcca gcctcagggc actcgggcct gggtgggagt caacgccttc ccctctggac      660

tcaaataaaa cccagtgacc tc                                               682


<210> 2719
<211> 1213
<212> DNA
<213> Homo sapiens

<400> 2719
gggggagcga gccggtgctg ctgcaggctg aggctgcggc agaggcggcg aggcgcgggc       60

ggtgaggacg gacagtcacc gacttagtcc agttccctgt gatctcaaaa caattgttgc      120

agcaggctcc tggcagtctc aagcagttca tcttcttggt gtactggttt cctattgtga      180

ttttatcatg gaaaatcaat tggctaaatc aactgaagaa cgaacatttc agtaccagga      240

ttctcttcca tcactgcctg ttccttcact tgaagaatca ttaaaaaaat accttgaatc      300

agtgaaacca tttgcaaatc aagaagaata taagaaaact gaagaaatag ttcaaaaatt      360

tcaaagtggg attggagaaa aattgcacca gaaattgctt gaaagagcaa aaggaaaaag      420

aaattgggta tttgttgtta taattgaata atgatgatgt ttaaagaatg ataaataaaa      480

agtgcatagt ttttattttt aaattattgc tgtaaaaatt tttacagtta ttattgttat      540

tttcataatc caaaagaagg aatgaatcac ttaactttgg gagttttcag tgggtggatt      600

cgggaacttg ttaaaatgca gatttgctgg gataagtgat tctgattcac atggctggaa      660

tgaggcccag agattcttat tttaacaatc acttcatgtg gtttggctgc aggtaatctg      720

tagaccatgc tgaaggaaaa cattttgtcc aggtgactag cttgaaaaat cagaaacact      780

aaaatagaca tgtcacatag gtggcataga aatattttcg tagtacaatg gagaaaggga      840

atcattaaaa atcagagtgg agaatggtta tgtatattgt atatttcagt tagataaatt      900

gaggaagcta gtataataat tattgaaggt ctcaataatt ttccacaaaa ttctttaact      960

tcttcagctc aaccatttct gtacttctct actatgaatc agaggatgag gttgtataat     1020

tcaaaagcat tgccttagtc tagaaataat tattgtacct atcatttagt tttagaaata     1080

aaaagcaagc tgattttttt tgatgaacca tttatatctg tgatggaata ataaaatttc     1140

acacttccgg attcctttgt tctcaatttt gagccttgag ttgttttaat taaagagggg     1200

taaaggtaaa gaa                                                        1213


<210> 2720
<211> 3848
<212> DNA
<213> Homo sapiens

<400> 2720
agacgcagag gcgaggccgc cagtcgagga cgaggaggag ataacatcaa gatgccgaag       60

actgaggaaa ctgtgctcca gaatgatccc agtgtagcag agaatggggc ccctgagcct      120

aaaacaccag ggcagagcca gaaaagcaag agtttctgtt tagatgacca gtctcctgac      180

ctgatgtctt ttctgtcaca gatctgatag agacagttaa tgaagtttcc aagctgagca      240

tttcacatga aattgtagta aaccaagatt tctatgtgga agagaccatt ttgcctccaa      300

acagtgtaga aggcaggttt gcggaggcaa tgtacaatgc tttttggaac catctgaaag      360

aacagctatt gagtactcct cctgacttca cttgtgccct tgaacttcta aaagatgtta      420

aggagacctt gctatcactg ctattaccat ggcagaaccg cctaagaaat gagatagaag      480

aagctctgga cacagatctc ctcaagcagg aagcagaaca tggggccctg gatgtccctc      540

atctttctaa ctacattctc aatttgatgg ctctgctatg tgcaccggtt cgagatgaag      600

cgatacagaa actagagacc ataagagatc cagtgcagtt actgaggggc atcctccgtg      660

ttctgggcct aatgaaaatg gacatggtga actataccat ccagagcttt cgaccctacc      720

tgcaggaaca ttccatccag tatgaacaag ctaaattcca ggaactcctt gataaacagc      780

ccagtctcct cgattatacc acaaaatggc taaccaaagc agccacagac atcactacac      840

tatgtccgag ttctcctgac tcacctagct cctcctgcag catggcgtgt tcacttccaa      900

gcggggcagg taacaattca gagcccccca gtccaacaat ggtgctatac caaggctacc      960

tgaacctcct cctctgggat cttgaaaacg tagaattccc agagactctg ctgatggaca     1020

gaatccggct ccaggaactg gcattccagt tgcaccagtt aactgtcctg gcctcagtct     1080

tgctagtggc cagaagcttc tctggtgaag ttttattcag atcacctgaa tttgtggata     1140

gactgaaatg caccaccaag gccctaactg aggaatttat ctccaggcct gaagagacta     1200

tgctgagtgt gagtgaacag gtgtctcagg aagtccatca aggccttaag gacatgggcc     1260

tcactactct gagcagtgaa aacacagcat ctcttctagg ccaactccag aacatcacca     1320

agaaagagaa ctgcattcgt agcattgttg gagtctctgc tacactttcc tggaggcctc     1380

attctcattg aaaaggagtt ggcagaactg ggctggaagt ttctcaatct gatgcatcat     1440

aatcagcaga gtcatttttc acaaaacgaa atctttccag aagatcacga ataagagaga     1500

tcaaagctag gcagcttgag ttgaagtaga gctggaagaa ggagttttga ggactgtttc     1560

aaaaccactg gactagatga tctctaaagg atcttatcca ggacgcttca ttgcatttgg     1620

tcttcatttc tccttagtct cctccaggct gacatttcct caatctttat tggtcttcca     1680

cagccctgac acttttggag ataccagtca gcatttccaa gttcgttctg tgagactgta     1740

gtgtcaggac aaagcaacaa caaaatgtgc tctactctaa agaagtgtgg gacatacaga     1800

actgaagttg cagaatgcca tgaccatggt agcacttttc aaggaagaaa gaaaggtggg     1860

agttctttcc gggataattt tgacaagagg agctgtcatt atgaacatgg tgggtatgag     1920

cgcccgcctt cacactgcca ggagaatgat ggaagcgtgg agatgaggga tgtccacaag     1980

gaccaacaac taagacacac tccttatagc atccgatgcg aaagaagaat gaaatggcat     2040

agtgaagacg aaatccgtat taccacgtgg agaaatagaa aacctccgga gagaaaaatg     2100

agtcagaaca cacaggatgg atacacaagg aactggttta aggtcacaat tccttacggg     2160

ataaagtatg acaaggcatg gctaatgaat tcaatccaga gccattgcag tgaccgcttc     2220

actccggttg atttccacta cgtccgaaat cgggcatgct tctttgtcca ggatgctagc     2280

gctgcctccg cattgaagga tgtcagttat aagatttatg atgatgagaa ccaaaagata     2340

tgtatatttg tcaatcattc tactgcgccc tactctgtga agaataagtt gaagccaggc     2400

caaatggaga tgctaaagct gaccatgaac aaacggtaca atgtctccca gcaagctctt     2460

gatctccaga atctccgctt tgacccagac ttgatgggcc gtgacattga tataatcctg     2520

aatcgaagaa actgcatggc tgccaccctg aagatcattg aaagaaattt ccctgagctg     2580

ttgtctttga acttgtgcaa caacaagctg taccagctgg atggcctttc tgacattaca     2640

gagaaggctc ccaaagtcaa gaccctgaat ctctccaaaa ataagctgga gtcggcgtgg     2700

gagttgggca aggtgaaagg gctgaagctc gaagagctat ggctagaagg gaacccgttg     2760

tgcagcacct tctcggacca gtccgcctat gtaagtgcca tccgggattg tttccccaag     2820

ttgttacgcc tggacggccg agagttatcc gcaccagtga ttgttgacat tgacagctct     2880

gagacaatga aaccctgcaa ggaaaacttt actggatctg agaccctaaa gcatttagtc     2940

ctgcaattcc tgcagcagta ttactcgatc tatgactctg gagatcgaca gggtctcctc     3000

ggtgcttacc acgatgaggc ctgcttctcc ttggctattc ccttcgaccc caaggactca     3060

gccccgagca gcttgtgcaa gtactttgag gatagcagga atatgaaaac actcaaggac     3120

ccctacctga agggggaact gctgaggcgc acaaaacgtg acattgtgga ctccctcagt     3180

gcgttgccca aaactcagca tgacctcagc tccatcctgg tggacgtgtg gtgccagacg     3240

gaaaggatgc tctgcttttc tgtcaatggg gttttcaagg aagtggaagg acagtctcag     3300

ggttctgttc tcgccttcac ccggaccttc attgctaccc ctggcagcag ttccagtctg     3360

tgcatcgtga atgacgagct gtttgtgagg gatgccagcc cccaagagac tcagagtgcc     3420

ttctccatcc cagtgtccac actctcctcc agctctgagc cctccctctc ccaggagcag     3480

caggaaatgg tgcaggcttt ctctgcccag tctgggatga aactggagtg gtctcagaag     3540

tgccttcagg acaatgagtg gaactacact agagctggcc aggccttcac tatgctccag     3600

accgagggca agatccccgc ggaggccttc aagcaaatct cctaaaagga gccctccgat     3660

gtcttctttg tcttcgttca catcctcttt gtttcctctt ttcaccagcc taaggcctgg     3720

ctgaccagga agccaacgtt aacttgcagg ccacgtgaca taaccaccca aagagccagt     3780

tgctctgtgt attcgcccca ctcatgatca ccattttatt ttcataataa agagtgacgt     3840

tacacgtt                                                              3848


<210> 2721
<211> 4211
<212> DNA
<213> Homo sapiens

<400> 2721
agtctcttcc ccaactctcc ccacccctgg tgctctccgc cccgcttgcc tcccgttctt       60

ccccgcccgc tccatccggg tcgctgacgg ctgtctctgg actggacagc agtggcgtcc      120

gcttttctct aaggaacccg ataagaactc cattttctgt tgatgtggag acatagggta      180

cctccaactt tccggggttt cagaagagaa ttttttattg aaactggaag accaaaataa      240

ttacaagcat gttgtgctgg ggaaatgcat cctttgggca gctaggtttg ggtggaattg      300

atgaagaaat tgtactagag cccagaaaaa gtgacttctt tataaataaa agggtccgag      360

atgtaggatg tggactcaga catactgtgt ttgttctgga tgatggaaca gtgtacacat      420

gtggatgtaa tgatctagga cagctaggtc atgaaaaatc cagaaagaaa ccagagcagg      480

ttgttgccct ggatgcccaa aatattgtag ctgtttcatg tggagaagct catacgttag      540

cgctaaatga caaaggccag gtgtatgctt ggggtctcga ttctgatgga cagcttggcc      600

tggtaggatc agaggaatgc atcagagtac ccagaaatat taaaagtttg tcagatatcc      660

agattgtaca ggttgcttgt ggttactatc attcacttgc actttctaaa gcaagtgaag      720

tcttctgttg gggacagaat aaatatggcc aattgggttt aggtactgac tgtaaaaagc      780

aaacttcacc gcagctgctt aagtctttgc ttggaatccc tttcatgcaa gttgcagcag      840

gaggagccca tagttttgta ctcacccttt ctggagctat ctttggatgg ggacgcaaca      900

agtttggtca gctaggtctt aatgatgaaa atgataggta tgttcctaat ttactaaagt      960

cactaagatc tcagaaaata gtttatattt gttgtggaga agatcatact gctgctctaa     1020

ccaaggaagg tggagtgttt acttttggag ctggagggta tggtcagttg ggccataatt     1080

ctaccagtca tgaaataaac ccaaggaaag tttttgaact tatgggaagc attgtcactg     1140

agattgcttg tggacggcag cacacttctg cttttgttcc ttcatcagga cgaatttact     1200

cttttgggct tggtggtaat gggcagctgg gaaccggttc aacaagcaac aggaaaagcc     1260

cctttactgt aaaaggaaat tggtacccct ataatgggca gtgtctacca gatattgatt     1320

ctgaagaata tttctgtgta aaaagaattt tctcaggggg agatcaaagc ttttcacatt     1380

actctagtcc ccagaactgt gggccaccag atgacttcag atgtcccaat ccgacaaagc     1440

agatctggac agtgaatgaa gctctaattc agaaatggct gagctatcct tctggaaggt     1500

ttcctgtgga gatagccaat gagatagatg gaacgttttc ttcctctggt tgcctaaatg     1560

gaagtttttt agctgttagc aatgatgatc actatagaac aggtaccaga ttttcagggg     1620

ttgatatgaa tgctgctagg cttttattcc acaaacttat acaacctgat catccgcaga     1680

tatctcagca ggtggcagct agtttggaaa agaatcttat tcctaaactg actagctcct     1740

tacctgatgt tgaagcattg aggttttatc ttactctacc agaatgtccc ctgatgagtg     1800

attccaacaa tttcacaaca atagcaattc cctttggtac agctcttgtg aacctagaaa     1860

aggcaccact gaaagtactt gaaaactggt ggtcagtact tgaacctcca ctattcctca     1920

agatagtaga actttttaag gaagttgtgg tacatctttt gaaactctac aagatcggta     1980

ttcccccttc tgaaagaaga attttcaaca gttttcttca tactgcatta aaggttttag     2040

aaatactaca tagggtaaat gagaaaatgg gacagattat acagtatgat aaattttata     2100

tacatgaagt acaagaattg atagacataa gaaatgatta tatcaactgg gtccaacagc     2160

aggcctatgg aatggatgtc aaccatggat taactgagtt ggcagatatc cctgttacaa     2220

tctgtacata tccatttgta tttgatgccc aagcaaaaac tactctgtta cagaccgatg     2280

cagtcttaca gatgcagatg gctattgatc aggcccacag gcagaatgtc tcctctcttt     2340

ttctcccagt gattgaatct gtgaatccct gcttaattct agtggtgcgt agagaaaata     2400

ttgtaggaga tgcaatggaa gtccttagga aaacaaagaa catagattac aagaagccac     2460

tcaaggttat atttgttgga gaagatgctg tggatgcagg aggggtgcgc aaagaatttt     2520

tcttgctcat catgagggaa ttattggatc ctaaatacgg catgtttagg tattatgaag     2580

attccaggct catttggttt tctgataaga tcacagttga aaactttggt gcaacagaag     2640

tgaaagagct ggttctaaat ggtgcagaca cagctgttaa caaacaaaat cggcaagagt     2700

ttgtcgatgc ttatgtggat tacatattca ataaatcagt ggcttcctta tttgatgctt     2760

ttcatgcggg ctttcataag gtctgtggag gaaaagtcct tctgctcttt cagcctaatg     2820

aactacaagc aatggtcatt ggaaatacaa attatgattg gaaggaactg gaaaagaata     2880

cagaatacaa aggggaatat tgggcagaac atcctacgat aaaaattttt tgggaagtat     2940

ttcacgaatt accattggaa aagaagaaac agtttctgtt atttttgaca ggtagtgatc     3000

gcattcctat tcttggtatg aagagtctga aactagtcat ccagtccaca ggaggtggtg     3060

aggagtatct cccagtttcc catacttgtt ttaatcttct ggatcttcca aaatatacag     3120

aaaaagaaac tctacgctct aaactgatcc aagctattga tcacaatgaa ggcttcagtt     3180

taatataact ttggagttat aactattcag tttagtgcaa aagcattaaa ctatttgtgt     3240

ttttcttgtg gtgatgaatt cagcaaggtg acagaggtac tattataatt cttacttgca     3300

gaatgttcaa tctacgagtg ttcatggaag ccaaaaaata ttaaaggaaa atgaacaaac     3360

tgttaatatt attgtacaga accatggatt ttttttgacc atcttctaat aaacatagca     3420

agtattatga atacattaaa gttttactaa catgaatttt aagagtttgc atatttcaga     3480

aatgatctgg tgtgagtgca tggaaatatt gcttaatttt tcttcaatca ttgagtgaaa     3540

aacctttaac tttggcctgc aatagtcatt tgattatttt ttcattttgt aaataatgtt     3600

aagttttgta ataaaatagt tatgttctga taccagtaca gtttctatgg ttgtaattga     3660

acttgaacag acttttaaag gttaaaaatt atgatttaaa tcttactctg agactctata     3720

aaaagaaaaa aaaggtagca tggtggaaac actatctttt cttttttgct agaataagtg     3780

tctttgtgca aacctaaatc acagataggg aatatactac ataacctgca gttcttttct     3840

ttgtgaatcc tgacacactg atagatgggg gattgtcgat cagagaactt attaatattt     3900

agtactggaa gaactctgtc tccacagttg ccagtaataa aaagaaacat tggctactat     3960

gagcaccaat cactgggtta tagctttcaa aattattgat gctgcagtgc tttagagcta     4020

tttccttgaa tttaagaaac aaatcttaac agttttatgg tgctgatgct tagttgtctc     4080

atgccattaa attgtaaaag tgagttgatg caatacatgt gactttctgc tataatgcaa     4140

atatttattt tttaaattta ttttaaaatg ccgtgaaaac tgtttaataa agatttattg     4200

ttttaatatt t                                                          4211


<210> 2722
<211> 1566
<212> DNA
<213> Homo sapiens

<400> 2722
agccattcct gaggaggact gccggtcgtt cggacgtctt gcctgtcgct ggaggagagg       60

tccgggctct ccaggaaggt ggctgcggcg acaaaatgaa gatattcgtg ggcaacgtcg      120

acggggcgga tacgactccg gaggagctgg cagccctctt tgcgccctac ggcacggtca      180

tgagctgcgc cgtcatgaaa cagttcgcct tcgtgcacat gcgcgagaac gcgggcgcgc      240

tgcgcgccat cgaagccctg cacggccacg agctgcggcc ggggcgcgcg ctcgtggtgg      300

agatgtcgcg cccaaggcct cttaatactt ggaagatttt cgtgggcaat gtgtcggctg      360

catgcacgag ccaggaactg cgcagcctct tcgagcgccg cggacgcgtc atcgagtgtg      420

acgtggtgaa aggcaaacga atgcacgtgc agttgtccac cagccggctt aggactgcgc      480

ccgggatggg agaccagagc ggctgctatc ggtgcgggaa agaggggcac tggtccaaag      540

agtgtccgat agatcgttca ggccgcgtgg cagacttgac cgagcaatat aatgagcaat      600

acggagcagt gcgtacgcct tacaccatga gctatgggga ttcattgtat tacaacaacg      660

cgtacggagc gctcgatgcc tactacaagc gctgccgtgc tgcccggtcc tatgaggcag      720

tggcagctgc agctgcctcc gtgtataatt acgcagagca gaccctgtcc cagctgccac      780

aagtccagaa tacagccatg gccagtcacc tcacctccac ctctctcgat ccctacgata      840

gacacctgtt gccgacctca ggagctgctg ccacagctgc tgctgcagca gcagccgctg      900

ctgctgttac tgcagcttcc acttcatatt acgggcggga tcggagcccc ctgcgtcgcg      960

ctacagcccc agtccccact gttggagagg gctacggtta cgggcatgag agtgagttgt     1020

cccaagcttc agcagccgcg cggaattctc tgtacgacat ggcccggtat gagcgggagc     1080

agtatgccga tcgggcgcgg tactcagcct tttaaagctt gaggtgggat gtgtgtgggc     1140

tgaaattccg agctgcggtt gtgcatgaga atacaccctt cgtggtaccc catctccggg     1200

acgttctcgg ctctgtgcgt tcagtccctc aggaaccgtg gaccttaatt taccttgcta     1260

agttcagacc ttctcttcct ttcctttcct ttcctctcct gcccattttc ctgttcttct     1320

gtccttcaat acttctgtag cttcccattc atgttctctt ctcccagcag gcctcattgt     1380

gtgcagaaac tgtggtgggg gctgtgctgt ctcctccctg cctcctgcct cctgcggctg     1440

ttggatttgg gaatgacctt ggtgagagtc tcactgctcc agggtctctt tttggtccaa     1500

aggctagacc tatagagttg gatcactttt tttctttccg gtgaaataaa tggtttttca     1560

acttag                                                                1566


<210> 2723
<211> 884
<212> DNA
<213> Homo sapiens

<400> 2723
atcttgagtg agggcacgct ctccttagag gggcggaaca gtttttggca ccttatcgcg       60

agcggcagct tatgcaagag tgacttaaaa aagaaaggca ggtccggggc caggggctaa      120

gtagcggtgc ggtttctttt tctggattag tttccccatc ttgcctaaaa atgtcctagt      180

ctagtctttt tagcagaact ccactcccta aacatgtcag aactacactt cccatcaagg      240

gtcagaaaga aacttccggc acagtctttt cccagcattc cttgtttact tccgggttta      300

ttactactga aggaagaacg ccagatcaga aaagggagct caggtacctt ccagagagtg      360

agacccagcg cccttgtctc gcacccagta ggctttcatc cccgccatgg cggagctgat      420

ccagaagaag ctacagggag aagtggagaa atatcaacag ctacagaagg acttaagtaa      480

atccatgtcg gggaggcaga aacttgaagc acaactaaca gaaaataata tcgtgaaaga      540

ggaactggcc ctgctggatg ggtccaacgt ggtctttaaa cttctgggtc cggtgctagt      600

caaacaggag ctgggggagg ctcgggccac agtagggaag aggctggact atatcacagc      660

tgaaattaag cgatacgaat cccagcttcg ggatcttgag cggcagtcag agcaacagag      720

ggagaccctt gctcagctgc agcaggagtt ccagcgggcc caggcagcaa aggcaggggc      780

tcctggcaag gcctgacccc atggtggggg gaggggaggg gaggggaggg aatgaggcag      840

ctctaggatc tatactgtag ctaataaaat gtaaaaacac ctgg                       884


<210> 2724
<211> 3220
<212> DNA
<213> Homo sapiens

<400> 2724
aactttgcct ctcctttacg ccaaatacgt gtccttatat ctgaatctac accactatta       60

tagattcacc ttctttgaga agtccctatt tgaagagagg aaaattcagg ctacttgtaa      120

ccctcttatt ctttttagac ggagttttcc ctcttgttgc ccaggctaga gtgcaatggc      180

gcgatctcgg ctcaccgcaa cctccgcctc ccgggttcaa gcgactctcc tgcctcagcc      240

tcccgagtag ctggaattac aggcatgcgc caccactccc ggctaatttt gtatttttag      300

tagagacggg gtttctccat attggtcagg ctggtctcaa acccccggcc tcagcctcag      360

gtgatccgcc cgcctcggcc tcccaaactg gtggggttac aggtgtgagc cacggaacgc      420

ggctcctctt ccttctggat atggctgtct cagatggcca gaggcctcgg aaaggcttcc      480

ggtttcccgg caggcccgag tggggctgaa cttccggcct caggacgcag gcgcgggccg      540

ctcatttcgc tctttccggc ggtgctcgca agcgaggcag ccatgtctta tcccgctgat      600

gattatgagt ctgaggcggc ttatgacccc tacgcttatc ccagcgacta tgatatgcac      660

acaggagatc caaagcagga ccttgcttat gaacgtcagt atgaacagca aacctatcag      720

gtgatccctg aggtgatcaa aaacttcatc cagtatttcc acaaaactgt ctcagatttg      780

attgaccaga aagtgtatga gctacaggcc agtcgtgtct ccagtgatgt cattgaccag      840

aaggtgtatg agatccagga catctatgag aacagctgga ccaagctgac tgaaagattc      900

ttcaagaata caccttggcc cgaggctgaa gccattgctc cacaggttgg caatgatgct      960

gtcttcctga ttttatacaa agaattatac tacaggcaca tatatgccaa agtcagtggg     1020

ggaccttcct tggagcagag gtttgaatcc tattacaact actgcaatct cttcaactac     1080

attcttaatg ccgatggtcc tgctcccctt gaactaccca accagtggct ctgggatatt     1140

atcgatgagt tcatctacca gtttcagtca ttcagtcagt accgctgtaa gactgccaag     1200

aagtcagagg aggagattga ctttcttcgt tccaatccca aaatctggaa tgttcatagt     1260

gtcctcaatg tccttcattc cctggtagac aaatccaaca tcaaccgaca gttggaggta     1320

tacacaagcg gaggtgaccc tgagagtgtg gctggggagt atgggcggca ctccctctac     1380

aaaatgcttg gttacttcag cctggtcggg cttctccgcc tgcactccct gttaggagat     1440

tactaccagg ccatcaaggt gctggagaac atcgaactga acaagaagag tatgtattcc     1500

cgtgtgccag agtgccaggt caccacatac tattatgttg ggtttgcata tttgatgatg     1560

cgtcgttacc aggatgccat ccgggtcttc gccaacatcc tcctctacat ccagaggacc     1620

aagagcatgt tccagaggac cacgtacaag tatgagatga ttaacaagca gaatgagcag     1680

atgcatgcgc tgctggccat tgccctcacg atgtacccca tgcgtattga tgagagcatt     1740

cacctccagc tgcgggagaa atatggggac aagatgttgc gcatgcagaa aggtgaccca     1800

caagtctatg aagaactttt cagttactcc tgccccaagt tcctgtcgcc tgtagtgccc     1860

aactatgata atgtgcaccc caactaccac aaagagccct tcctgcagca gctgaaggtg     1920

ttttctgatg aagtacagca gcaggcccag ctttcaacca tccgcagctt cctgaagctc     1980

tacaccacca tgcctgtggc caagctggct ggcttcctgg acctcacaga gcaggagttc     2040

cggatccagc ttcttgtctt caaacacaag atgaagaacc tcgtgtggac cagcggtatc     2100

tcagccctgg atggtgaatt tcagtcagcc tcagaggttg acttctacat tgataaggac     2160

atgatccaca tcgcggacac caaggtcgcc aggcgttatg gggatttctt catccgtcag     2220

atccacaaat ttgaggagct taatcgaacc ctgaagaaga tgggacagag accttgatga     2280

tattcacaca cattcaggaa cctgttttga tgtattatag gcaggaagtg tttttgctac     2340

cgtgaaacct ttacctagat cagccatcag cctgtcaact cagttaacaa gttaaggacc     2400

gaagtgtttc aagtggatct cagtaaagga tctttggagc cagatttgtc gtctcattat     2460

tgtaggagag aatttgtggg ttgtggcagt aatacatttc ccatgtgtcc tgatgctttc     2520

aggatacatc agttgttagt gtttaaattg agttattttt attttgtgct tttgagatgg     2580

agtctcactc tgtctcccag gctggagtgc agtagcgtga tctcagttcg ttgcatcctc     2640

cgctgcccag gttcaagcag ttctgcctca gccttccaag tagctgggat tacaggcgtg     2700

tgccaccaca ctcagctaat ttttgtattc tcagtagaga tgggttttac catgttggcc     2760

aggctggtct cgaactcctg gcctcaagtg attcgcctgc cttggcctcc caaaatgtgc     2820

taggattaca ggcatgagcc accacgcccc gcctaaattc aaaatctttt tgtttttttt     2880

tagacggagt ctcactctgt cgcccaggtt ggagtgtact ggcgcgatct cggctcactg     2940

caagctccac ctcccaggtt cctgccattc tcctgcctca gcctcccaag tagctgggac     3000

tacaggcacc cgccaccatg cccggccaat tttttgtatt ttttagtaga gatggggttt     3060

caccgtgtta gccaggatgg tctcagattt cctgacctcg tgatctgccc atctctgcct     3120

cctaaagtac tgggattaca ggcgtgagcc accgtgccca gccctaaatt gaattcttaa     3180

atccctcttg ttcataaagc agtatatttg gtttacagga                           3220


<210> 2725
<211> 1083
<212> DNA
<213> Homo sapiens

<400> 2725
ttcttaatgg aatccaagcc tctaagcctc acagtccagg ccctccacca gcctgcctca       60

ccctatcctc atttcatctc ccgcaacctg gctccgagtc agaggttccg gttgagatca      120

agttgggaga cacacccttg ttcattctcc ttgagaagca gctattatca acagaacatt      180

gacagaacct gtgtttgggg aaaggactga tggctttgag tctaggttgg aaagcacaca      240

ggaaccactg tggtctcctc ttgcaggctc tgcgaagcag tggtcttctc ttgtttccct      300

gtggccagtg tccctggaga ggagctggaa gctttttgga ccctgagata aaggctttcc      360

tggaggagaa cactgaagtc accagcagtg gtagcctcac ccctgaaatc cagttgcggc      420

ttttgacccc cagatgcaaa ttctggtggg agagagctga cctgtggccc cacagtgatc      480

cttactgggc aatctactgg ccaggaggcc aagccctgtc taggtatctt ttggataatc      540

ctgatgttgt cagaggaaaa tctgtattag atcttgggag tggatgtgga gctacagcta      600

ttgctgctaa gatgagtggg gcatcaagga tcttggccaa tgacatagac cctattgcag      660

gaatggctat tacactaaat tgtgaattga acagactgaa tccttttcct attttaatcc      720

aaaacatttt gaatttggaa caagataagt gggaccttgt tgttcttggc gatatgtttt      780

atgatgaaga ccttgcagat agtcttcatc agtggctgaa gaagtgcttc tggacctata      840

gaactcgagt actgattggt gaccctgggc ggccccagtt cagtggacac agcattcagc      900

atcacctgca caaagtggta gaatattcac ttttggagtc tactaggcag gaaaacagtg      960

gactgacaac aagcacagtg tggggttttc agccttgagt tgtcaaagtg cttccaagta     1020

tgaatatagt aatgtttgga tctgactcta aaagttttct ctataggaga tactctccag     1080

ttt                                                                   1083


<210> 2726
<211> 2006
<212> DNA
<213> Homo sapiens

<400> 2726
ccgagctggg ggcgcagagc gcgggaggcg gcggcggcgc ggagcccagg tggctccgct       60

gccggatggg agtgccccag tgtgctggat gaagctggcg catgcaccat gtcatcatgt      120

gtctctagcc agcccagcag caaccgggcc gccccccagg atgagctggg gggcaggggc      180

agcagcagca gcgaaagcca gaagccctgt gaggccctgc ggggcctctc atccttgagc      240

atccacctgg gcatggagtc cttcattgtg gtcaccgagt gtgagccggg ctgtgctgtg      300

gacctcggct tggcgcggga ccggcccctg gaggccgatg gccaagaggt cccccttgac      360

acctccgggt cccaggcccg gccccacctc tccggtcgca agctgtctct gcaagagcgg      420

tcccagggtg ggctggcagc cggtggcagc ctggacatga acggacgctg catctgcccg      480

tccctgccct actcacccgt cagctccccg cagtcctcgc ctcggctgcc ccggcggccg      540

acagtggagt ctcaccacgt ctccatcacg ggtatgcagg actgtgtgca gctgaatcag      600

tataccctga aggatgaaat tggaaagggc tcctatggtg tcgtcaagtt ggcctacaat      660

gaaaatgaca atacctacta tgcaatgaag gtgctgtcca aaaagaagct gatccggcag      720

gccggctttc cacgtcgccc tccaccccga ggcacccggc cagctcctgg aggctgcatc      780

cagcccaggg gccccattga gcaggtgtac caggaaattg ccatcctcaa gaagctggac      840

caccccaatg tggtgaagct ggtggaggtc ctggatgacc ccaatgagga ccatctgtac      900

atggtgttcg aactggtcaa ccaagggccc gtgatggaag tgcccaccct caaaccactc      960

tctgaagacc aggcccgttt ctacttccag gatctgatca aaggcatcga gtacttacac     1020

taccagaaga tcatccaccg tgacatcaaa ccttccaacc tcctggtcgg agaagatggg     1080

cacatcaaga tcgctgactt tggtgtgagc aatgaattca agggcagtga cgcgctcctc     1140

tccaacaccg tgggcacgcc cgccttcatg gcacccgagt cgctctctga gacccgcaag     1200

atcttctctg ggaaggcctt ggatgtttgg gccatgggtg tgacactata ctgctttgtc     1260

tttggccagt gcccattcat ggacgagcgg atcatgtgtt tacacagtaa gatcaagagt     1320

caggccctgg aatttccaga ccagcccgac atagctgagg acttgaagga cctgatcacc     1380

cgtatgctgg acaagaaccc cgagtcgagg atcgtggtgc cggaaatcaa gctgcacccc     1440

tgggtcacga ggcatggggc ggagccgttg ccgtcggagg atgagaactg cacgctggtc     1500

gaagtgactg aagaggaggt cgagaactca gtcaaacaca ttcccagctt ggcaaccgtg     1560

atcctggtga agaccatgat acgtaaacgc tcctttggga acccattcga gggcagccgg     1620

cgggaggaac gctcactgtc agcgcctgga aacttgctca cgaagcaagg cagcgaagac     1680

aacctccagg gcaccgaccc gccccccgtg ggggaggagg aagtgctctt gtgagaggca     1740

gtccctgcgt ggaaagttgc tgggcccccg cccccggctc ccccgcacgc atgcatccac     1800

tgcggccgga ggaggccatg gagcccgagt agctgcctgg atcgctcgac ctcgcatgcg     1860

cgccgcgtcg cctctggggg gctgctgcac cgcgtttcca tagcagcatg tcctacggaa     1920

acccagcacg tgtgtagagc ctcgatcgtc atctctggtt atttgttttt tcctttgttg     1980

ttttaaaggg gacaaaaaaa aaaaaa                                          2006


<210> 2727
<211> 1129
<212> DNA
<213> Homo sapiens

<400> 2727
aggcttgaaa aagaggtcag gccccaggag ctgggctgga gcagtgagga gtgtttcttc       60

caagagaaga tgactgcctg agaggattat ttatgaggat ggcctgtgca aaaagacacc      120

cagagatttc atgctgttga ttcacagaaa gcctgttcct cttcactccg tagagtcctc      180

agagtctgga tcatccctta cagaagatcc ttgataatat ttctgatata cctccaaggt      240

tccgtttgtc aaatgtgtgc gacccttctg ataagtcacc agaggtgatg agggagagag      300

agaaagaaag caaattacaa ctgtaaagag tctctgaaca gtgaaagatc aaaacagaca      360

gtctctggct ttactggatg agtcaccatt gcagcccgac cgcaaaaaca agcgtggctt      420

ctgtacttag cagcagtctt cctgtctgga aaggaaacat tgctcagatt ggagatactg      480

gccattttat agacttcaaa gcaacttagg ccactgaact gtcaggcggg aaaacaggat      540

gtcttccatt tggaagcccc tttgcttcta agaagttcca gagaccatcc caggcccaca      600

gagttataag gattcatctg ggcactgaag acatttggga cctcagtgaa gtttctccga      660

ggccagatgg tcacattgat tttctggaat cattttgaat aaaaatgagc gaggtggtga      720

acacaatgca aggctctcca cgtactgtct ggtattgttc aaccagctcc acgactccct      780

gagggcagag atgagcagat gttaatggat aaagccaggc tgaagaaatg tcaacaattg      840

ggagttttga aggattccag gctgtgtctc tgaagcaaga gggagatgac caaccctctg      900

agactgacca cctatcgatg gaggaagagg acccgatgcc aagacagatt tcaaggcagt      960

caagtgtgac cgaatcaact ctttacccca atccttatca tcagccttat atctcacgga     1020

agtactttgc tacacggccg ggggccattg agactgccat ggaagacttg aaaggtcacg     1080

tagctgagac ttctggagag accattcaag gcttctggct cttgacaaa                 1129


<210> 2728
<211> 2067
<212> DNA
<213> Homo sapiens

<400> 2728
ctttcaaagc caatttgaat aaacaactct tccctctcaa atgggcaaga gtaactcttc       60

agcaccatgg agaggtccgg gcagcgtgtt acaacgtggg actgtgacca gggcaagcac      120

tctgacagtg attaccgaga ggatgggatg gatctaggca gtgacgccgg cagcagcagc      180

agcagcagcc gcgccagttc acagtccaac tccaccaaag tgaccccttg ctccgagtgc      240

aaatcttcat cgtcgccggg gggcagcctg gacttggtgt ctgccctgga ggactatgag      300

gagcccttcc cggtctacca gaagaaggtg attgatgagt gggcgccgga ggaggacggg      360

gaggaggagg aagaggagga cgagcgcgac cagcgagggt accgggatga ccgctctccg      420

gcccgggaac cgggggacgt aagcgccagg acccgcagcg gcggcggcgg gggcaggagc      480

gccaccaccg ccatgccgcc cccggtgccc aacggcaacc tccaccagca cgacccccag      540

gacctcaggc acaatggcaa cgtggtggtg gctggccggc cgagctgttc ccggggcccc      600

cgccgggcga tccaaaagcc ccagccggct gggggccggc gcagtggccg cggcccggcg      660

gctggggggc tctgccttca gcccccagac ggcgggacgt gcgtccccga agagcccccg      720

gtgccaccta tggattggga ggcgctggag aagcatctgg ccgggctgca gttccgggag      780

caggaggcac agaaaaatga gagagagtct atcagacaga agttggcact tggaagcttc      840

tttgatgatg gcccaggaat ttataccagc tgtagcaaaa gtgggaagcc aagcctttcc      900

tcccgactgc agagtgggat gaacttgcag atatgctttg tcaacgacag tggcagtgat      960

aaggacagtg atgctgatga cagtaagact gaaaccagct tggacacccc cttgtctccc     1020

atgagcaaac agagttcttc ctattctgat agagacacta ctgaagagga gtctgaatcc     1080

ttggatgaca tggacttcct tacaaggcaa aagaaattgc aagctgaagc caaaatggcc     1140

cttgccatgg ccaaaccaat ggccaaaatg caagtagaag tggagaaaca gaacaggaaa     1200

aagtctcccg tcgctgatct tctgccacac atgcctcata taagtgaatg cttgatgaaa     1260

agaagtttaa aacccaccga cctgagagac atgactattg ggcagctaca agtgatagtc     1320

aatgatctcc attcccagat agaaagcttg aatgaagagt tggtccagct gcttctcatc     1380

cgagatgagc tgcacacaga gcaggatgcc atgctggtgg acattgaaga cttgaccaga     1440

catgctgaaa gtcagcagaa gcacatggca gagaaaatgc ctgcaaagtg aaaagaagcc     1500

attcaaccag agaacaagct agaatttatt ttgcttctgt ggttgtaaaa atgctgttgc     1560

taaaggtggc gcagaaacaa atatcagtgt tagtcattga taatgtctga agcttaatgt     1620

ccagtgattg gcctttgctt cttaatttat tttaattttt tacttgtgcc acttaatatc     1680

aggcatttta ataaaatatt gttacaaaaa atgtacagta ctgacaccac cacaaatcat     1740

ggttaataaa agagagtagt tttaacttta tttttatttg tttagagatt ttaagttgga     1800

acagtatttt cccattgact acttttcatt cttcactgta gttttaaaga agaactgtaa     1860

atgacggtgc tatacaagtc aaaaaataca tgcctgcctc gtagtgaagt tgtagctctc     1920

cgtaatatgt atattttact cagttttcaa cattttgtga atgttgacta cctgaagttc     1980

ctttttagat gtgctattaa cattctgttg gattcagagg gttccttgaa agttttatgt     2040

ataaatatgt aaaataaaaa ttaaaac                                         2067


<210> 2729
<211> 1893
<212> DNA
<213> Homo sapiens

<400> 2729
agctgattcc cggggttggt ggcagcggcg gtagcagcaa tggactttct cctggggaac       60

ccgttcagct ctccagtggg acagcgcatc gagaaagcca cagatggctc cctgcagagc      120

gaggactggg ccctcaacat ggagatctgc gacatcatca acgagacgga ggaaggtccc      180

aaagatgccc tccgagcagt aaagaagaga atcgtgggga ataagaactt ccacgaggtg      240

atgctggctc tcacagtctt agaaacctgt gtcaagaact gcgggcaccg cttccacgtg      300

ctggtggcca gccaggactt cgtggagagt gtgctggtga ggaccatgct gacggagctg      360

gtgcccaccc aggccgagcc cgcagacctg gagctgctgc aggagctcaa ccgcacgtgc      420

cgagccatgc agcagcgggt cctggagctc atccctcaga tcgccaatga gcagctgaca      480

gaggagctgc tcatcgtcaa tgacaatctc aacaatgtgt tcctgcgcca tgaacggttt      540

gaacggttcc gaacaggcca gaccaccaag gccccaagtg aggccgagcc ggcagctgac      600

ctgatcgaca tgggccctga cccagcagcc accggcaacc tctcatccca gctggcagga      660

atgaacctgg gctccagcag tgtgagagct ggcctgcagt ctctggaggc ctctggtcga      720

ctggaagatg agtttgacat gtttgcgctg acacggggca gctcactggc tgaccaacgg      780

aaagaggtaa aatacgaagc cccccaagca acagacggcc tggctggagc cctggacgcc      840

cggcagcaga gcactggcgc gatcccagtc acccaggcct gcctcatgga ggacatcgag      900

cagtggctgt ccactgacgt gggtaatgat gcggaagagc ctaagggggt caccagcgaa      960

gaatttgaca aattcctgga agaacgggcc aaagccgcgg accgattgcc caacctctcc     1020

agcccctcag ctgaggggcc cccgggtccc ccatctggcc cagcgccccg gaagaagacc     1080

caggagaaag atgatgacat gctgtttgcc ttatgagtgt ggggtctggc accctgcagc     1140

ccaggtcccc actgctctca cacccttagg ctgggacctc cctccctcct ctggtgttaa     1200

ggctgctttg ggggtggctt gttaccccct tttcctcctc tttgaagacg gagctgcccc     1260

agctgtggct gggggtgtgg aggcagtggg atgaactggg ggacaggtct gcgctgcagt     1320

gggatctggc tgctctgcct cctttcccac cccagctgac catgagactt tgctgagaag     1380

tggaggcccc aggacaggct ggctggctgg ctggctgctt gacccagtgt gactctcctt     1440

cactgagtga taccctgctc cgggcccatg ccccaaggag cccttcagag cccacactgc     1500

cagtcgaggc ctggctggag gctggccaca gtggaaattc tgccgagcct cttgtccctt     1560

ccctgctctg ctgcatgggg ccccatggct ttggctggcc actgagggta gggtgtggag     1620

gtgtggaggc cccctgagga gctgcggcgg cccaggtacg aagctgcaac tctgcgcgca     1680

gtgggcgaga tctcatcagc cccaggctgc aggtgaggct tcaggggatg ctggggcccc     1740

actgcccctc cgctgccttg ccctccatcc ttcctctgtt ccttctggcc gggcaccaca     1800

gcactggggc tcacctcttg gttgatcctc ttgtactggg agaggtgcct tttgtatccc     1860

caattaaagg tagaaaacca ccctgctagc agc                                  1893


<210> 2730
<211> 2081
<212> DNA
<213> Homo sapiens

<400> 2730
gaacacttca gcacctgtag cacagaaggg ccaaggagct gcagtcctcg accagcagga       60

ggtttgctcc tcagcccact cgctgcatcc agatcagctc acccctctcc cttccctgcc      120

caccaggact ctgatagccc ctggcagcca cagcccattt tgccaagatg tctagagtag      180

ccaaatatcg ccggcaggtg agtgaagacc ccgacatcga cagcctgctg gagaccctgt      240

ctcccgagga gatggaggag ctggagaagg agctggacgt ggtggaccca gacgggagtg      300

ttcccgtggg gctgcggcag agaaaccaga cggagaaaca gtccacgggt gtgtacaacc      360

gggaggccat gctcaacttc tgtgaaaagg agaccaagaa acttatgcag agggagatgt      420

ccatggatga aagcaagcaa gtggagacca agacagatgc caaggaggag aagatcatcc      480

ggggcattga caagggccgg gtcagggctg cagtggataa gaaggaggca gggaaggatg      540

ggagaggaga ggagagggca gtggccacca agaaggaaga ggagaagaaa gggagtgaca      600

ggaacacagg cttgagcagg gacaaggata aaaagagaga ggagatgaag gaggtggcca      660

agaaagagga tgatgagaag gtaaaagggg agcgtaggaa cacagacacc agaaaagagg      720

gtgagaagat gaaaagagca ggtgggaaca cagacatgaa aaaggaggat gagaaggtaa      780

aaagaggaac tgggaacaca gacaccaaaa aggacgatga aaaagtcaag aagaatgaac      840

ccttacatga aaaggaagcc aaggatgaca gcaagaccaa aacacccgag aaacagacgc      900

ccagtggccc caccaagccc tctgaaggac cggccaaggt ggaggaggag gcagctccca      960

gcatatttga tgagcctctg gagagagtga agaacaatga ccccgagatg actgaggtga     1020

acgtcaacaa ctcagactgc atcacaaatg agatcttggt ccggtttact gaggctctgg     1080

agttcaacac tgtggttaag ctgttcgcct tggccaacac gcgagccgat gaccacgtgg     1140

cctttgccat tgccatcatg ctcaaggcca acaagaccat caccagcctc aacctggact     1200

ccaaccacat cacaggcaaa ggcatcctgg ccatcttccg ggccctcctc cagaacaaca     1260

cgctgaccga gctccgcttc cacaaccagc gacacatctg tggaggcaag acggagatgg     1320

agatcgccaa gctgctgaag gagaatacta ccctgctcaa gctgggctac cattttgagc     1380

tggccgggcc ccgaatgact gtcaccaatc tgctcagccg caacatggac aagcagagac     1440

aaaagcggct gcaggagcaa aggcaggcac aggaagccaa gggagagaag aaggatctgc     1500

tggaggtacc caaggccggg gccgtggcta agggctcccc aaaaccttca cctcaaccat     1560

ctccaaagcc ctctccaaag aactcaccca aaaaaggggg tgctccagct gccccaccac     1620

cccctccccc tcccttggct ccacccctta tcatggagaa cctgaagaat tcactctcac     1680

cagctaccca gaggaagatg ggagacaaag tcctccctgc ccaggagaag aactcccgtg     1740

accagctatt ggctgccatc cgctccagca acctcaagca gctcaagaag gtggaagtgc     1800

ccaaactgct tcagtaggac caggctgcca ggcaccatct gccaatgcca tgactgctca     1860

ggcctcacct cccagggcta cacagaccct gcccacccca tccctggctg acctgctgtg     1920

gatgtcccta ttctgccatg ggagagtcca ggcctgggtc acgctcaagg aaggatgcct     1980

tatctcttct cactttcctt ttcttgtctc tgaggctctc caaattttgc tttagtacat     2040

ggagctcagg tttctggaca agaagagtcc ttttagcaca t                         2081


<210> 2731
<211> 339
<212> DNA
<213> Homo sapiens

<400> 2731
gtgacctcga ggcagcctca gcacggcact ctcttgggtc ctcttccagg ctcacactgg       60

gcgacagcgg agaggctctt ggacggggca gagctcgcgc cgagacctgc atgtccgcgt      120

cttgtgacgg gtgtgtggga agccgcccgc ctgtgcatct tgcttccggg tattcgctgg      180

ctgatttact ggttttagag atggggatgg gcacccagtg ctggactgaa gaccagagaa      240

ggtggagctc cctgtggcct tggtctcacc tctcttcaga cccaagcctg cccaatgtgc      300

aggtgaccag gctgacactc ctgtcggaac aggctccgg                             339


<210> 2732
<211> 1884
<212> DNA
<213> Homo sapiens

<400> 2732
gctgaggacg gggcggggcc tcgcgctaac ggtcgcgcgg ccgtcgcacc tgcacgaggc       60

tgtggcccga gcgtcctgtg gagaagccgc gaagcgcggg cgacccgggg gtcgggcggg      120

ccaggtccgc gaggccgcgg cggcagctgt gcaggcccgg ggagcagccg gccgggcgag      180

cctcggatta aaaaaatggc aaactccttt gcagcgagga ttttcactac cctttcagat      240

ctgcagacaa atatggctaa tctgaaagtt atcggtatag ttattgggaa aacagatgtc      300

aaaggctttc cagacagaaa aaatattgga tcagaaaggt acactttcag cttcaccatt      360

cgggattcac cagcacattt tgtaaatgca gcttcctggg gcaatgaaga ttacatcaag      420

tctctttctg acagctttag ggttggtgac tgtgtgataa ttgaaaatcc tctgatccaa      480

agaaaggaaa tagaaagaga agaaaaattc agccctgcaa ctcctagcaa ctgtaaactg      540

ttgctcagtg agaatcactc aacagtaaaa gtttgttcca gttatgaagt ggacacaaag      600

ttactttctt tgatacattt acctgttaaa gagtctcatg attattattc actgggtgac      660

attgttgcaa atggacacag tcttaatggg aggattatta acgtgcttgc agctgtgaaa      720

tcggttggag agccaaaata ctttacaact tcagaccgga gaaaaggcca gaggtgtgaa      780

gttagactct atgatgaaac agagtcgtct tttgcgatga catgttggga taatgaatcc      840

attctacttg cacagagctg gatgccacga gaaacagtaa tatttgcctc agatgtaaga      900

ataaattttg acaaatttcg gaactgcatg acagcaactg taatctcaaa aaccattatt      960

acaactaatc cagatatacc agaagctaac attctgctga attttatacg agaaaataaa     1020

gaaacgaatg ttctggatga tgaaattgac agttatttca aagaatccat aaatttaagt     1080

acaatagttg atgtctacac agttgaacaa ttaaagggaa aagctttgaa gaatgaagga     1140

aaagctgatc cttcctatgg catcctttat gcctacattt ccacactcaa cattgatgat     1200

gaaactacaa aagtagttcg aaatagatgt tccagctgtg gttatattgt aaatgaagca     1260

tctaacatgt gcacaacttg caacaaaaac tccttggact ttaaatctgt ctttctcagt     1320

ttccatgtgc tgattgatct gactgatcac acaggcaccc ttcattcctg tagtctcaca     1380

ggaagtgttg ctgaggagac tttgggctgc acggtacatg agtttcttgc aatgacagat     1440

gaacagaaaa cagcattaaa gtggcaattt ctcttggaaa gaagcaaaat ttatttaaaa     1500

ttcgttctat cacacagagc aaggagtgga ttgaaaatta gtgtactctc gtgcaagctt     1560

gcagatccta ctgaggcaag cagaaacttg tctggacaaa aacatgttta aaacggtcta     1620

tcattttgaa ctctggaaaa gtataagagt tttaactccc tttaaaatgg aatattaatt     1680

tgaaaattat ggggaaaatt gcattttgtt tacatgtggt gaacatgttt ctagaaattg     1740

ttatggtgga ggtggtctgg gtgagtctga aggcctctct catctgacct cccttcttag     1800

aaggcctcct actgtctttg ccttgtctcc tcccaagttg gaaaatgttt acatgaatta     1860

ataaacagat ttaatcttct acag                                            1884


<210> 2733
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 2733
acggggcggg gacgagctgt cgcgctggtt gctcgtgcag gagcgggacc cggaacagac       60

cgccgtgaga gaggaggggt gccggccggg attcgcggcc cggagctcgg gaccggagtc      120

aggaatggag agaagggtaa tggttttacc tcttattgtg gaaacctgtt gagatcacag      180

agaatatact gacggcataa aagggcagaa ccatagcagg gtgcggttgc ttcattccag      240

cctcgcagtc acctctgtgc cctgctggtt gtcttcccag cgctgctgta gttgccttcc      300

atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg aacggagacc      360

tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg aagaggaggt      420

gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact gtggccacgt      480

cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc ccgtctgccc      540

actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac tggccagcct      600

ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag aggtgacccg      660

ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact actactgtga      720

ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca ggccccacac      780

ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga accacctgag      840

taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag aagctgatat      900

cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg agtttgagca      960

gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg cgaagctgga     1020

gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg agcttgcccg     1080

gctggccctg gtcatctccg aactggaggg caaggcgcag cagc                      1124


<210> 2734
<211> 3636
<212> DNA
<213> Homo sapiens

<400> 2734
cggcaactcc acccggcgct gaccccctca actctgcagg acccggcgcg cgaggacccc       60

acgacccgcg ggcgcctgcg cggaccccgc gagccccggc gcctgcgcga gtccccgacg      120

ccgcccccgc ccccactcac cgggccccgc agcaggggcc ggagccgccg gcggcggggc      180

gggggggggc gccccgatga gccccgagtg cgaggagccg ccgccccccc tcgcagggcg      240

ccatgttttg gaagtttgac ctgcacacaa gctcgcacct ggacacgctg ctggagcggg      300

aggacctgag cctgcccgag ctgctggacg aggaagacgt gctgcaggag tgcaaggtcg      360

tcaaccgcaa gctgctggac ttcctgctgc agccacccca cctgcaagca atggtggcct      420

gggtcaccca ggagccgcca gatagcggtg aggagcggct gcgctacaag taccccagtg      480

tggcctgcga gattctgacc tcagatgtgc cccagatcaa tgatgccctg ggtgctgatg      540

agtcccttct gaaccggctc tacggcttcc tgcagagcac cggcagcctc aacccactgc      600

tggccagctt cttcagcaag gtcatgggca tcctcatcaa ccgcaagaca gaccagctcg      660

tgtcctttct tcggaagaag gatgacttcg tggacctgct gctgcagcac attggcacct      720

cggccatcat ggacctcctg ctgcgcctgc tcacctgtgt ggagcggcct cagctgaggc      780

aggatgttgt caattggctc aacgaggaga agatcgtcca gcggctgatt gagcagatcc      840

acccgtcgaa ggatgagaat caacattcca acgcatccca gtccctgtgt gacatcatcc      900

gcctgagccg ggagcagatg atccaagtcc aggacagccc agagcctgac caactgctgg      960

ccaccctgga gaagcaggag acgattgagc agctcttaag caacatgttc gagggggagc     1020

agagccagtc tgtcatcgtc agtgggatcc aggtgctgct gaccctgctg gagcccagga     1080

ggccgaggtc cgagtccgtg accgtgaaca gcttcttcag cagtgtggat gggcagctgg     1140

agctcctggc ccagggggcc ctggaaagca ctgtgtccag tgtgggcgcc ttgcacgccc     1200

tacgcccgcg gctcagctgc ttccaccagc tcctgctgga gcctcccaag ctggagccgc     1260

tacagatgac atggggcatg ctggctccgc ctctgggcaa cacgcggctg cacgtggtca     1320

agctcctggc cagtgccctg agcgccaatg atgcagccct gacgcacgag ctcctggcac     1380

tggacgtgcc caacaccatg ctggacctct tcttccatta tgtcttcaac aacttcttgc     1440

atgcccaagt agagggatgc gtgagcacca tgctgagctt ggggccacct cctgacagca     1500

gccctgagac gcccatccaa aaccctgttg tgaaacatct gctgcagcag tgccgcctgg     1560

tggagcggat cctgacgtcc tgggaggaga acgaccgtgt acagtgtgcg ggaggccctc     1620

ggaaaggcta catgggtcac ctgacaagag tggccggtgc cctggtgcag aacacggaga     1680

aggggcccaa tgcagagcag ctgcggcagc tgctgaagga gctgcccagc gagcagcagg     1740

agcagtggga agccttcgta tcggggcccc tggcggagac caacaagaag aacatggtgg     1800

acctggtgaa cacccaccac ctacactcct ccagtgacga tgaggacgac cggctcaagg     1860

agttcaactt ccctgaggag gctgtgctgc agcaggcctt catggacttc cagatgcagc     1920

gcatgacctc tgccttcatt gaccacttcg gcttcaatga tgaggagttt ggggagcagg     1980

aggagagtgt gaacgcacct tttgacaaga cagccaacat caccttctcc ctcaatgctg     2040

acgatgagaa ccccaacgcc aacctacttg agatatgcta caaggaccgc atccagcagt     2100

ttgatgatga tgaggaagag gaggacgagg aagaggccca gggctcaggg gagtctgatg     2160

gagaagatgg cgcctggcag ggcagccagc tggccagggg ggcccgtctg ggccagccac     2220

ctggtgtccg gagtggaggc agcacagaca gtgaggacga agaagaggag gacgaggagg     2280

aggaggaaga cgaggagggc attggctgtg cagcccgtgg aggggccacc cctctgtcct     2340

accccagccc tggccctcag cctccaggcc ccagctggac agccaccttt gacccagtgc     2400

ctacagatgc cccgaccagc ccccgagtct ccggggagga agagctgcac actgggcctc     2460

cagccccaca ggggcccctc agtgtgcccc agggcctccc cactcagagc ctggccagcc     2520

ctcctgcccg tgacgccctg cagctcaggt ctcaggaccc cacacccccc tcagcacctc     2580

aggaagccac agaaggcagc aaagtcacgg agccctcagc cccttgccag gccttggtta     2640

gcatcgggga ccttcaggcc accttccacg ggatccgttc tgcccccagc tcctcggaca     2700

gtgcaaccag agacccctct acctctgtcc cagcctccgg ggcccaccag cccccccaga     2760

ccacagaagg ggagaagagc ccagagccct tggggcttcc ccaaagccag agtgcccagg     2820

ccctcacgcc tcctccgata cccaatggct ctgccccgga agggcctgca tccccaggct     2880

cccaatagct gcctggtgcg gcagcggcgg ccaaatcttc cgtcctcccg tggatctccc     2940

ggggtggggg cagggcgggt cccacgatgg cccccattgc cctcatcacc ctgacacccc     3000

cacattctct cctctggacc cccaggaggc tggtgccagg gagacaggcc caacccaccc     3060

ccatttgcac tgagaagaga agttttggag cgttgcctcc tagaataaag atacagagag     3120

tcaaatagag agaatggaga gagagaaaca tatattatat attatataga gagagggagg     3180

agagcgagag agagtgagga caccgaactg ggctggcggc tccaaagcac agccttccct     3240

gttccgtccc agcgggagct ggtgttaggg gtcccaaggt tgccacccac gtgcccagct     3300

gtcccacgct gcagcgcaga cggccacgcc cacacccggc cttttagctc aggtccacca     3360

tgggggacgg cccagcgtgg gtgggggtgc cagagggtcc cgagtggggg ccgtgccttt     3420

gcccagaccc tgcactttca accaggccag tccggctctg gggagcaggg gcctccccgg     3480

caacagcccc aggggccttg agggtctgag gtcccagccc tgttgccaag tgaccttgtc     3540

cccagctccc tcctcccagg ctggtgtgag tgtgcgtgcg tttgtgccga gcttctattt     3600

catattgcaa atataaataa aggaaggcag tttacg                               3636


<210> 2735
<211> 1851
<212> DNA
<213> Homo sapiens

<400> 2735
gaaaagccgc cggtatttct ccacctggct ctcctctacc tccaggcagg cgcacccgag       60

gtccccctcc caccccacct tctgccctcc cgcacacttg gaccagtgct gttgacccgg      120

aagcggacat ttctgcagct attctaagca cacgtcggcg gagggagcgg gacgtggcca      180

gcggtcagcg gcgaaggagg caggccctgc gcggggatca cggaagccct gtgattcacc      240

atgaagttcc agtacaagga ggtccatccc tttgagtatc ggaaaaagga aggagaaaag      300

atccggaaga aatatccgga cagggtcccc ttgattgtag agaaggctcc aaaagcaagg      360

gtgcctgatc tggacaggag gaagtaccta gtgccctccg accttaccga tggccagttc      420

taccttttaa tccggaagag aatccacctg agacctgagg acgccttatt cttctttgtc      480

aacaacacta tccctcccac tagtgctacc atgggccaac tatatgagga cagtcatgag      540

gaagatgatt ttctgtatgt ggcctacagt aatgagagtg tctatgggaa atgagtggtt      600

ggaagcccag cagatggaag cacctggact taggggtagg ggaggggtgt gtgtgtgact      660

tggggaaaga gagggcggct cccaccgtga ggagacagaa ggtgaagaca tatagaaact      720

ttacaccgca cacaccgtca acgcattttc acatgctcaa ctgatatttt ttgttgcttc      780

cttggcccag ggagaaagca tgtcaggaca gagctgttgg attggctttg atagaggaat      840

ggggatgatg taattttatg gcattcctga gatttaattt ttgtgcagtt tcatagaaag      900

gtcggtcagg aggtggacaa gttggggtca gagatgatgg cagtccagca gcaactccct      960

gtgctccctt ctctttgggc agagattctg tttttgacag ttgcacaaga caggtaggga     1020

aaggggactt gtggtagtgg gccatacctg gggacgaaaa gagacccact gtaattgatg     1080

catcgtggcc cccgatcttc cgtatcccac acttcttttc tcccatccca gttgcaatct     1140

cactcacaaa catcacagta ccaccccagg ggcggcagta gacaccaacc cagaaattta     1200

gacagggatc tcttatcttt ggaaaatagg ggttaggcat gagggtggtt atgattaaga     1260

agataatttt gttgttaaat agcattaaac tggaattgac agagtgagtt gagcatctct     1320

gtctaacctg ctctttctct ctggtgctcc tcatctcacc cctaccttgg aatttaataa     1380

gcttcaggca tttccaattg cagactaaaa ccacttctac catctcctct agtattttcc     1440

atgtatcagg acagagatgt cttatgtagg gaaggggcag gtatgaagtg aggtagatta     1500

tctatacctc tcactcattc aggattctcg ctcccatgct gctgtccctt cattctcaca     1560

ctcacaggaa tgctatgtga tggccagctg cttcccttct tggttatcca ctgcagctgc     1620

tagttagaaa ggtttgcagg gatgactttt agtaaatcat ggggatttta ttgatttatt     1680

atcacttata ggattttgtg gggtgggagt ggggagcagg aattgcactc agacatgaca     1740

tttcaattca tctctgcaaa tgaaaagggt tcttcctctt gggggaaatc tgtgtgtcag     1800

ttctgtcagc tgcaagttct tgtgtaatga agtcaatgct gtcaggccaa g              1851


<210> 2736
<211> 1594
<212> DNA
<213> Homo sapiens

<400> 2736
gtgctccgcc gtctccgccg catcttccac cctcgccgcc gccgcagctc cccgcgctcg       60

tgccaccgcc gccgcgtcca ccctcagcgc caccgccatg cgggagatcg tgcacctgca      120

ggccggccag tgcggcaacc agatcggggc caagttttgg gaggttatca gtgacgaaca      180

tggcatcgac cccacaggca cataccatgg ggacagtgac ctgcaactgg agaggatcaa      240

cgtgtactac aacgaggcca caggaggaaa ttatgtcccc agagcggtgc tggtggacct      300

ggaacccggc accatggact ctgtccgttc tggccccttc ggtcagatct ttcggccgga      360

caacttcgtg tttggccaat ccggagccgg caacaactgg gcaaaggggc actacacgga      420

gggcgcagag ctggtggacg ctgtcctgga cgtagtccgg aaggaggccg agagctgcga      480

ctgccttcag ggcttccagc tgaccacccc cacctacggg gacctcaacc acctggtgtc      540

ggccaccatg agcggggtca ccacctgcct gcgcttcccg ggccagctga acgccgacct      600

gcgcaagctg gccgtcaaca tggttccctt tcctcgcctg cacttcttca tgcccggctt      660

cgcacccctg accagccggg gcagccagca gtaccgggcc ctgacggtgc ccgagctcac      720

ccagcagatg ttcgatgcca agaacatgat ggcggcgtgc gacccgcgcc acggccgcta      780

cctgaccgtg gccgccgtgt tccggggccg catgtccatg aaggaggtgg acgagcagat      840

gctgagcgtg cagagcaaga acagcagcta cttcgtggag tggatcccca acaacgtgaa      900

gacggccgtg tgcgacatcc cgccccgcgg cctgaagatg gccgcgacct tcatcggcaa      960

cagcacggcc atccaggagc tgttcaagcg catctccgag cagttcacgg ccatgttccg     1020

gcgcaaggcc ttcttgcact ggtacacggg cgagggcatg gacgagatgg agttcaccga     1080

ggccgagagc aacatgaatg acctggtatc tgagtaccag cagtaccagg acgccacggc     1140

cgaggagggc gagttcgagg aggaggcgga ggaggaggtg gcctaggctg ctcccatcgc     1200

ttcccacctg tcccctcgag gcttctgacc tttgatccgc taggcccccc atctctgaac     1260

cctagagccc cgctttccct ccaaggctga ctccccgctg accctaacaa tacctttgga     1320

gctcgcttta cctctggcta cttcatctcc gaccctggct cccctttgag ccctaattta     1380

tctttaaccc ccttgagctc ttccaacctt gacattccca ggaggagccc cgcttcaccc     1440

cttctgactc tggaaaccgc acctttaact ttgcagacct tccttcaccc ctgacttctg     1500

cttcaccttt gacctctgcc ccccatgaat cccattttac ctctagacct ataagttctg     1560

gtttatgttt gacccctccc tctgagctgc actt                                 1594


<210> 2737
<211> 877
<212> DNA
<213> Homo sapiens

<400> 2737
gcacagcagt gacgacacac aaggtttcgg ggactgagtg ggtttcagac tttctctcag       60

gatttccgct ggcttcaggt tccggtcagg cgtcgggaca gagcctgatc caggcttcgg      120

cggccggtgg cagctctcga tcagctctcg cagtcggaga ggcggctaag gaaaggtgcc      180

acagcagaga cgcgaaggag aggccctaga accttttcaa agaagaatgg aagaaaccat      240

gaagcttgct acgatggaag acacagtgga gtactgcctg ttcctgatac cagatgagtc      300

aagggactca gataaacata aagagattct tcagaagtac attgagagaa taatcactcg      360

gtttgcacct atgctggtcc cctacatctg gcagaatcag cctttcaatc ttaaatataa      420

acctgggaaa ggaggtgttc ctgctcatat gtttggcgtg acaaagtttg gggataacat      480

tgaggatgaa tggtttattg tttatgtaat aaagcagatc acaaaggaat ttccagagtt      540

agtagcaagc accaataggg tatttttctg ccatggggaa ttgtgtatta tccctgcacc      600

aagaaaatct ggagcagaat cttggttacc caccacaccc ccaacaattc cacaagcatt      660

gaatataatc acagcacatt cagaaaaaat acttgcttca gaatctatac gagctgctgt      720

gaataggcgc atcagagggt acccagaaaa aattcaggcc tcacttcatc gagcacactg      780

cttccttcca gctggcattg tggcagtgct aaagcagcgc cccagattgg tggctgcagc      840

agtccaggca ttttacctac gagaccctat tgacctg                               877


<210> 2738
<211> 3007
<212> DNA
<213> Homo sapiens

<400> 2738
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg tggatggcca gggtacctgg     1200

ggactcaggc tgctgccagt tctgctcacc accatccgtg cttggcacag aagtagctgc     1260

atagaaaggg cactggattt gaagtcagaa gacctgggtt cttgaaccag cctgtcaacc     1320

agttgtatga ctttaaacaa ggcatctcac ctcttttcat cttgttttct tccaataatg     1380

ttagagttca tgtaatcaca ttctctagaa ccatttagtt tgtgttaact atgaaccaag     1440

cagtgtggtg gccactggtg acttgaaaat atagagaaaa aaaaaacctg ctctatatct     1500

gaaagagctc ttgggaagac agagaaacat aaagaggaaa ttacagcaca gtgtggtggg     1560

tgttacggga agtccaaccc cagcattatg ggagttcagg ggaaggggca tagcccagcc     1620

tggaaggaga gggtgagtgg gggatggctt tctgaaaagg gtggtctaaa ggatgcctat     1680

ggtcaatagg gaaaagaggg gaagaagcat cttaagaaga ggaaacagca gagaactggc     1740

tggatgacct gtgactctgg agcactgggt tgtctccatt gtcattatgg gcagatgtgt     1800

gccatcccca gccgacgcca ctcactgcct ccttcctcct ggtgttgcca cttctgggtg     1860

agattaaggt gcagggcctg ggggcaggag gacataaggt atagccataa atcataaccc     1920

agggaccaca ctcaacccta gggaaattgt cttcctgatc agttgattac catctgaggt     1980

caagaaatga gatagtggga gcaaatgggt cacaaatagc tcagctgtgg gctcagaaac     2040

tgctaggtaa aagaattcca gaaggaggcc agggcataag ttggatgacc tatgaacttt     2100

agtctaaaga attgagacta ccgtaattga gactactgta gtgacatctg agaaatggga     2160

tggaatagtg accatgtttt attttcttgt tcttgtcact attgtatttt attttgcata     2220

atcatgccct tcactgacag tctccttaac atcatctgtt tactctgctc agtgtaaact     2280

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2340

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2400

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     2460

gagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     2520

aaaatacaga cacacacaag tgcctatata atgataaaac atatccaaag cacccaaacc     2580

tgtgattcca gaaaagtaga tcctattttt gtttattttt attggcttta gctgtgtctt     2640

ttgaaaggac tattatcctc taaaatgtat gtgtatgaag atcctggctt gcagctcggg     2700

agctttacac accttgtgtc actttatctt ggtaacgagc caagatcatg caaccagttc     2760

atccatgtct gacccaagag ctcttaactg ctatgctgca ctgcctcatt cagagataga     2820

tgcctgcatg ggtcctggcg attattttaa tgctggctac acccccacag gtgacttgga     2880

ttcagaaata caatttatat ttcttctttt taaattgttt tattttattt ttcttttaat     2940

agttatatgt cagtgagaac aatttatatg tcttacactg agaaataaaa ctgctcataa     3000

gtgaaaa                                                               3007


<210> 2739
<211> 592
<212> DNA
<213> Homo sapiens

<400> 2739
tattttgggg gtggttggag gcggtggcgg cggcggcgag gaggggaatt tccttgtgcc       60

tccattcccg ggagggggga gcggcgttgg aggccaccgt ttccagcatc aacaacagca      120

acttgtgatt ggcggtgacc ggatattcag ttgcacatcc ccacatcaat gcactgccaa      180

tgatgaggaa actgaggcct tggactagaa cagaggtctc ctgactcagt ccaggactct      240

ttctattaca tcatgcggcc tgatatttgt ctttatggaa ctcagcaaca tcacatacag      300

gtagagacgg ggtttcaccg tgttagccag gatggtctca atctcctgac ctcgtgatct      360

gtccgccttg gcctcccaaa ggtttgggat tacagacgtg agccaccgca cccagccgat      420

attgttttat tttaatcaag gcaaaactgg ttatatcctg tgttgtgacc tcatggttta      480

agtgggaata aagatgagta taagcagtga tgaggtcaac ttcttggtat atagatactt      540

gcaagagtca ggattttctc attcagcatt tacctttggt atagaaagcc at              592


<210> 2740
<211> 1504
<212> DNA
<213> Homo sapiens

<400> 2740
gtgtcctccg gtcccctctg cctcaggcag ctgcatgttt gcctctgacc tcctcagggc       60

tttagattgc tgccctgggg cgggaagctc cggcctcctc ccccagctgg gcccccgaca      120

gctcctggca ttcacagtga actgtctggg gaatcatcgc tatttggggt tcttcgagga      180

cctggagcag cggcacaagg cccaggtgct ggtcgaggac atcagtgaca tcctggagga      240

gcacgctgag aagcacttcc acccctacat cgcctactgc tccaacgagg tctaccaaca      300

gcgcacgctg cagaagctga taagcagcaa cgccgccttc cgagaggccc tgagagagat      360

tgagaggcgg ccggcgtgcg ggggcctgcc catgctctcc ttcctgatcc tccccatgca      420

gcgggtgacc cggctgcccc tcctgatgga tacgctctgc ctcaagaccc agggccactc      480

cgaaaggtac aaggctgcca gccgtgcact gaaggccatc agcaagctgg tgaggcagtg      540

caacgagggg gcccacagga tggagcgcat ggagcagatg tacacgctgc acacacagct      600

ggacttcagc aaggtcaagt ccctcccact gatctctgcc tcccggtggc tgctgaagcg      660

cggagagctg ttcttagtgg aagaaaccgg actttttcga aaaattgcca gccggccaac      720

gtgctacctt ttcctgttca acgatgtcct ggttgtgacc aagaagaaga gcgaggagag      780

ctacatggtc caggactacg cccagatgaa ccacatccag gtggagaaga tagagccgtc      840

tgagctccct ctgcccgggg gcggcaaccg tagctcctcc gtgccccacc ccttccaggt      900

gaccctgctt cgcaacagcg agggccgcca ggagcagctc ctgctctcct cggactccgc      960

gagtgaccgg gcacggtgga tcgtggcgct cacacacagt gagagacagt ggcagggcct     1020

ctccagcaaa ggagacctgc cccaggtgga gatcaccaag gccttcttcg cgaagcaagc     1080

agacgaggtc acactgcagc aggcggacgt ggtcctggtt ctgcagcagg aggatgggtg     1140

gctctatggc gagaggctcc gggacggaga gacgggatgg ttccccgagg actttgcccg     1200

cttcatcacc agccgtgtgg ccgtggaggg caatgtccgc aggatggagc gtctgcgggt     1260

ggagacggac gtgtagccct ggcgaggcca gccggcggca gcacagcctg tctccaatca     1320

gcaagtggtc gtgcctggct ctagagagcg tggggagctg gtctcaagga cccagcatgg     1380

ttccctgggg cttcccaaga gcctgtggct gtggtgccgg gctccagaca cttcacggaa     1440

ggaagatcac atgtccccag agaggcaccc ccaggcaagc tcgagggggc cacaccgtgt     1500

ccca                                                                  1504


<210> 2741
<211> 2776
<212> DNA
<213> Homo sapiens

<400> 2741
ggtgaaaggt gaggggaaca gctgatccgt ctgttgggag gacagatatc tcaaggccag       60

gatggaagaa tcaccactaa gccgggcacc atcccgtggt ggagtcaact ttctcaatgt      120

agcccggacc tacatcccca acaccaaggt ggaatgtcac tacacccttc ccccaggcac      180

catgcccagt gccagtgact ggattggcat cttcaaggtg gaggctgcct gtgttcggga      240

ttaccacaca tttgtgtggt cttccgtgcc tgaaagtaca actgatggtt cccccattca      300

caccagtgtc cagttccaag cctgtaacca gctcgatgag agccagcaag aacggaatga      360

cctgatgcag ctgaagctac agctggaggg acaggtgaca gagctgagga gccgagtgca      420

ggagctcgag agggctctgg caactgccag gcaggagcac acggagctga tggaacagta      480

caaggggatt tcccggtccc atggggagat cacagaagag agggacatcc tgagccggca      540

acagggagac catgtggcac gcatcctgga gctagaggat gacatccaga ccatcagtga      600

gaaagtgctg acgaaggaag tggagctgga caggcttaga gacacagtga aggccctgac      660

tcgggaacaa gagaagctcc ttgggcaact gaaagaagta caagcagaca aggagcaaag      720

tgaggctgag ctccaagtgg cacaacagga gaaccatcac ttaaatttgg acctgaagga      780

ggcgaagagc tggcaagagg agcagagtgc tcaggctcag cgactgaaag acaaggtggc      840

ccagatgaag gacaccctag gccaggccca gcagcgggtg gccgagctgg agcccttgaa      900

ggagcagctt cgaggggccc aggagcttgc agcctcaagc cagcagaaag ccacccttct      960

tggggaggag ttggccagtg cagcagcagc cagggaccgc accatagccg aactacaccg     1020

cagccgcctg gaagtggctg aagttaacgg caggctggct gagctcggtt tgcacttgaa     1080

ggaagaaaaa tgccaatgga gcaaggagcg ggcagggctg ctgcagagtg tggaggcaga     1140

gaaggacaag atcctgaagc tgagtgcaga gatacttcga ttggagaagg cagttcagga     1200

ggagaggacc caaaaccaag tgttcaagac tgagctggcc cgggagaagg attctagcct     1260

ggtacagttg tcagaaagta agcgggagct gacagagctg cggtcagccc tgcgtgtgct     1320

ccagaaggaa aaggagcagt tacaggagga gaaacaggaa ttgctagagt acatgagaaa     1380

gctagaggcc cgcctggaga aggtggcaga tgagaagtgg aatgaggatg ccaccacaga     1440

ggatgaggag gccgctgtgg ggctgagctg cccggcagct ctgacagact cagaggacga     1500

gtccccagaa gacatgaggc tcccacccta tggcctttgt gagcgtggag acccaggctc     1560

ctctcctgct gggcctcgag aggcttctcc ccttgttgtc atcagccagc cggctcccat     1620

ttctcctcac ctctctgggc cagctgagga cagtagctct gactcggagg ctgaagatga     1680

gaagtcagtc ctgatggcag ctgtgcagag tgggggtgag gaggccaact tactgcttcc     1740

tgaactgggc agtgccttct atgacatggc cagtggcttt acagtgggta ccctgtcaga     1800

aaccagcact gggggccctg ccacccccac atggaaggag tgtcctatct gtaaggagcg     1860

ctttcctgct gagagtgaca aggatgccct ggaggaccac atggatggac acttcttttt     1920

cagcacccag gaccccttca cctttgagtg atcttactcc ctcgtacatg cacaaataca     1980

cactcatgca cacacacact cacacacatg catacactta ggtttcatgc ccattttcta     2040

tcacactggg ctccatgata ttctgttccc taagaactgc ttctgtgtgc cctgttttca     2100

tcccaagatt tctcacttca tcctctccta cctggctctt ttgtcccagg gaggggtcct     2160

gttcggaagc agtggctgaa tttatcccct gaaagtggtt ttggaggaac cgggatggag     2220

gaggccttcc cctgtgggaa tagaatcgtc cactcctagc cctggttgct tctgatacac     2280

agccactgca cacacacact cacactcaca ctcccttgtc tgatgcccca aagccaattc     2340

ctggggcacc ctaccctctc ttatttggag tttccgttgg tttacctgag ttttctctgg     2400

ggtctgcaca gaggcagcag catggacatc atggcctctc aggtcccttt tggttctcag     2460

tttcattggt tcctctttct gttcccccat tgacttctgt gccccaccct agccttttcc     2520

ataaccttag gtattcagtt tggaggggtt ttttgtattt ttgaggattc ctgtattctg     2580

tatcctctcc tcgcatctcc tcacatggaa agaaataatg tatttgtgcc ttctgtgagg     2640

aatgggggga acaagtggtc ccaggtatcc ccatttccaa ggcccccctc cctctccagg     2700

tccccccaca gcaataaaag cttccccctg atatccatcc ctttgtagtt tgaacaaata     2760

tatttatatg atatgt                                                     2776


<210> 2742
<211> 2671
<212> DNA
<213> Homo sapiens

<400> 2742
atgccgctga gctcccccaa cgccgccgcc accgcctccg acatggacaa gaacagcggc       60

tccaacagct cctccgcctc ttcgggcagc agcaaagggc aacagccgcc ccgctccgcc      120

tcggcggggc cagccggcga gtctaaaccc aagagcgatg gaaagaactc cagtggatcc      180

aagcgttata atcgcaaacg tgaactttcc taccccaaaa atgaaagttt taacaaccag      240

tcccgtcgct ccagttcaca gaaaagcaag acttttaaca agatgcctcc tcaaaggggc      300

ggcggcagca gcaaactctt tagctcttct tttaatggtg gaagacgaga tgaggtagca      360

gaggctcaac gggcagagtt tagccctgcc cagttctctg gtcctaagaa gatcaacctg      420

aaccacttgt tgaatttcac ttttgaaccc cgtggccaga cgggtcactt tgaaggcagt      480

ggacatggta gctggggaaa gaggaacaag tggggacata agccttttaa caaggaactc      540

tttttacagg ccaactgcca atttgtggtg tctgaagacc aagactacac agctcatttt      600

gctgatcctg atacattagt taactgggac tttgtggaac aagtgcgcat ttgtagccat      660

gaagtgccat cttgcccaat atgcctctat ccacctactg cagccaagat aacccgttgt      720

ggacacatct tctgctgggc atgcatcctg cactatcttt cactgagtga gaagacgtgg      780

agtaaatgtc ccatctgtta cagttctgtg cataagaagg atctcaagag tgttgttgcc      840

acagagtcac atcagtatgt tgttggtgat accattacga tgcagctgat gaagagggag      900

aaaggggtgt tggtggcttt gcccaaatcc aaatggatga atgtagacca tcccattcat      960

ctaggagatg aacagcacag ccagtactcc aagttgctgc tggcctctaa ggagcaggtg     1020

ctgcaccggg tagttctgga ggagaaagta gcactagagc agcagctggc agaggagaag     1080

cacactcccg agtcctgctt tattgaggca gctatccagg agctcaagac tcgggaagag     1140

gctctgtcgg gattggccgg aagcagaagg gaggtcactg gtgttgtggc tgctctggaa     1200

caactggtgc tgatggctcc cttggcgaag gagtctgttt ttcaacccag gaagagtttg     1260

ctgcaacagg gtgtgctgga gtatctgtct gccttcgatg aagaaaccac ggaagtttgt     1320

tctctggaca ctccttctag acctcttgct ctccctctgg tagaagagga ggaagcagtg     1380

tctgaaccag agcctgaggg gttgccagag gcctgtgatg acttggagtt agcagatgac     1440

aatcttaaag aggggaccat ttgcactgag tccagccagc aggaacccat caccaagtca     1500

ggcttcacac gcctcagcag ctctccttgt tactactttt accaagcgga agatggacag     1560

catatgttcc tgcaccctgt gaatgtgcgc tgcctcgtgc gggagtacgg cagcctggag     1620

aggagccccg agaagatctc agcaactgtg gtggagattg ctggctactc catgtctgag     1680

gatgttcgac agcgtcacag atatctctct cacttgccac tcacctgtga gttcagcatc     1740

tgtgaactgg ctttgcaacc tcctgtggtc tctaaggaaa ccctagagat gttctcagat     1800

gacattgaga agaggaaacg tcagcgccaa aagaaggctc gggaggaacg ccgccgagag     1860

cgcaggattg agatagagga gaacaagaaa cagggcaagt acccagaagt ccacattccc     1920

ctcgagaatc tacagcagtt tcctgccttc aattcttata cctgctcctc tgattctgct     1980

ttgggtccca ccagcaccga gggccatggg gccctctcca tttctcctct cagcagaagt     2040

ccaggttccc atgcagactt tctgctgacc cctctgtcac ccactgccag tcagggcagt     2100

ccctcattct gcgttgggag tctggaagaa gactctccct tcccttcctt tgcccagatg     2160

ctgagggttg gaaaagcaaa agcagatgtg tggcccaaaa ctgctccaaa gaaagatgag     2220

aacagcttag ttcctcctgc ccctgtggac agcgacgggg agagtgataa ttcagaccgt     2280

gttcctgtgc ccagttttca aaattccttc agccaagcta ttgaagcagc cttcatgaaa     2340

ctggacacac cagctacttc agatcccctc tctgaagaga aaggaggaaa gaaaagaaaa     2400

aaacagaaac agaagctcct gttcagcacc tcagtcgtcc acaccaagtg acactactgg     2460

cccaggctac cttctccatc tggtttttgt ttttgttttt ttttccccca tgcttttgtt     2520

tggctgctgt aatttttaag tatttgagtt tgaacagatt agctctgggg ggagggggtt     2580

tccacaatgt gagggggaac caagaaaatt ttaaatacag tgtattttcc agcttcctgt     2640

ctttacacca aaataaagta ttgacacaag a                                    2671


<210> 2743
<211> 689
<212> DNA
<213> Homo sapiens

<400> 2743
ggagaagggg cgcaggtggc cgccatcttg gattgcgaac tgggtcgcta cgcttcacgc       60

caggggcgga gtggcggccc ttctgttacc cgccacacac gtcgccgctg gggactggga      120

aatcagggca tcggagagtg ccacattaat gggtctctgg aacctggcgg tgccgggtgt      180

ttctcgtgtt ttccccaggg cgacagcggt cgcgggggcg tggcagccgg acctttccct      240

tgcggacgcg aaggcgtgat gccatggcta gtccagggaa agataactat agaatgaaaa      300

gttataagaa taaagcccta aatcctcaag agatgcgtag acgaagagaa gaagaaggaa      360

tacagcttag aaaacaaaaa agagaagaac agttgttcaa acgcagaaat gtctatttgc      420

ccagaaatga tgaatctatg cttgaaagtc ctatacagga tccagatatt agttccactg      480

tacccattcc agaggaagaa gttgttacta cagatatggt tcagatgatt ttttctaata      540

atgctgatca acagctaaca gcaacacaga aatttagaaa gctgctttct aaagaaccta      600

atccaccaat agatcaagtt atacagaaac caggagttgt acagagattt gtgaaatttc      660

ttgaaagaaa tgaaaattgc actttacaa                                        689


<210> 2744
<211> 550
<212> DNA
<213> Homo sapiens

<400> 2744
gattattgca attattatta tttatttttc atcttttttc aggttgacga tgtgtcacac       60

tgtgtaaggg aatcgcatgg agatgggcat tccgaactgt taatggggac atgggactcc      120

agttgtctct gatcacttgt gtggattttc ctggcgtaga acgacagaag ccgctagtaa      180

gtcgccaaga cctacagcag gaattctgca ccaaagggca taaaatcttg ttattttaat      240

ttgcatctgg gagaatgtct gagcaaggag acctgaatca ggcaatagca gaggaaggag      300

ggactgagca ggagacggcc actccagaga acggcattgt taaatcagaa agtctggatg      360

aagaggagaa actggaactg cagaggcggc tggaggctca gaatcaagaa agaagaaaat      420

ccaagtcagg agcaggaaaa ggtaaactga ctcgcagcct tgctgtctgt gaggaatctt      480

ctgccagacc aggaggtgaa agtcttcagg atcaggaatc aattcattta cagctttcca      540

gtttttccag                                                             550


<210> 2745
<211> 2702
<212> DNA
<213> Homo sapiens

<400> 2745
ggtttcaaat tggccctttg gcctctggag caaattcaaa tgtaactctt ccccaacccc       60

ccttctcttc ttccagatta attaaaagaa gaatgaacta taatccttga agataactgg      120

gcaatttttt aagtcggagg ctgttcttac tggtgtgagg atttacacac gtcttcagtt      180

tttcagcaca gaccagcaga ccatcatttt tagaggaaat actccctctg ccctcctttt      240

tggtttcctt ggtggtaaag attaaatttg gttgcatcat tttgacttgt gtttgagtct      300

agattttatg gcacaaggaa tggcataaac ttttcatgtg ttttggttaa aacaaaccag      360

accattgcat tgaccctgga catctttaat tgagaaattg gtaactttat tttaatatgt      420

atatctgaag aattcaagaa aacaaaggca tcctcagagg tgtgcctctt ttctttatta      480

ttagaggcaa aacgaacaat tttataggat ttgtagtgaa attataccag attataagga      540

gaaccaaaac taagtcgcaa aatttattaa tttaaggggc tctcgctttg aaagtttgag      600

agtaagttac gataggcatt tgtatccatt cattactttc ctcttttcaa ataagcaact      660

aaatagaaat gctaatctca gacttaatta tttaacagaa gagtgtacca tggaaaacct      720

ccagacaaat ttctccttgg ttcagggctc aactaaaaaa ctgaatggga tgggagatga      780

tggcagcccc ccagcgaaaa aaatgataac ggacattcat gcaaatggaa aaacgataaa      840

caaggtgcca acagttaaga aggaacactt ggatgactat ggagaagcac cagtggaaac      900

tgatggagag catgttaagc gaacctgtac ttctgttcct gaaactttgc atttaaatcc      960

cagtttgaaa cacacattgg cacaattcca tttaagtagt cagagctcgc tgggtggacc     1020

agcagcattt tctgctcggc attcccaaga aagcatgtcg cctactgtat ttctgcctct     1080

tccatcacct caggttcttc ctggcccatt gctcatccct tcagatagct ccacagaact     1140

cactcagact gtgttggaag gggaatctat ttcttgtttt caagttggag gagaaaagag     1200

actctgtttg ccccaagtct taaattctgt tctccgagaa tttacactcc agcaaataaa     1260

tacagtgtgt gatgaactgt acatatattg ttcaaggtgt acttcagacc agcttcatat     1320

cttaaaggta ctgggcatac ttccattcaa tgccccatcc tgtgggctga ttacattaac     1380

tgatgcacaa agattatgta atgctttatt gcggccacga acttttcctc aaaatggtag     1440

cgtacttcct gctaaaagct cattggccca gttaaaggaa actggcagtg cctttgaagt     1500

ggagcatgaa tgcctaggca aatgtcaggg tttatttgca ccccagtttt atgttcagcc     1560

tgatgctccg tgtattcaat gtctggagtg ttgtggaatg tttgcacccc agacgtttgt     1620

gatgcattct cacagatcac ctgacaaaag aacttgccac tggggctttg aatcagctaa     1680

atggcattgc tatcttcatg tgaaccaaaa atacttagga acacctgaag aaaagaaact     1740

gaagataatt ttagaagaaa tgaaggagaa gtttagcatg agaagtggaa agagaaatca     1800

atccaagaca gatgcaccat caggaatgga attacagtca tggtatcctg ttataaagca     1860

ggaaggtgac catgtttctc agacacattc atttttacac cccagctact acttatacat     1920

gtgtgataaa gtggttgccc caaatgtgtc acttacttct gctgtatccc agtctaaaga     1980

gctcacaaag acagaggcaa atgcatcaat ctcaaataat tctacaagta aaaggaaatc     2040

tgagtctgcc acttgcaact tagtcagaga cataaacaaa gtgggaattg gccttgttgc     2100

tgccgcttca tctccgcttc ttgtgaaaga tgtcatttgt gaggatgata agggaaaaat     2160

catggaagaa gtaatgagaa cttatttaaa acaacaggaa aaactaaact tgattttgca     2220

aaagaagcaa caacttcaga tggaagtaaa aatgttgagt agttcaaaat ctatgaagga     2280

actcactgaa gaacagcaga atttacagaa agagcttgaa tctttgcaga atgaacatgc     2340

tcaaagaatg gaagaatttt atgttgaaca gaaagactta gagaaaaaat tggagcagat     2400

aatgaagcaa aaatgtacct gtgactcaaa tttagaaaaa gacaaagagg ctgaatatgc     2460

aggacagttg gcagaactga ggcagagatt ggaccatgct gaggccgata ggcaagaact     2520

ccaagatgaa ctcagacagg aacgggaagc aagacagaag ttagagatga tgataaaaga     2580

gctaaagctg caaattctga aatcatcaaa gactgctaaa gaatagaaac tgttaaagag     2640

attcatctgt gtattactga caaggttttt tttgtttgtt gcttgctttg gtaattgaat     2700

tc                                                                    2702


<210> 2746
<211> 4012
<212> DNA
<213> Homo sapiens

<400> 2746
acggcacccg ccagtggggg tgcctcaact tccgcgggcg tttaaatagc agcctctctc       60

ccctcccacc ggtaataggc tgcctgctgt ttcccgggga gatcatgaaa cgaggtcgcc      120

ttcccagcag cagtgaggat tctgacgaca atggcagcct gtcaactact tggtcccaga      180

attcccgatc ccagcatagg agaagctcct gctccagaca tgaagatcga aagccttcag      240

aggtgtttag gacagacctg atcactgcca tgaagttgca tgactcctac cagctgaatc      300

cggatgagta ctatgtgttg gcagatccct ggagacagga atgggagaaa ggggtccagg      360

tgcctgtgag cccggggacc atccctcagc ctgtggccag ggttgtgtct gaagagaaat      420

ccctcatgtt catcaggccc aagaagtaca tcgtgtcatc aggctctgag cctcccgagt      480

tgggctatgt ggacatccgg acgctggctg acagcgtgtg tcgctatgac ctcaatgaca      540

tggatgctgc atggctggaa ctgaccaatg aagaatttaa ggagatggga atgcctgaac      600

tagatgaata caccatggag agggtcctag aggaatttga gcagcgatgc tacgacaata      660

tgaatcatgc catagagact gaggaaggcc tggggatcga atatgatgaa gatgttgtct      720

gtgatgtctg ccagtctcct gatggtgagg acggcaatga gatggtgttc tgtgacaaat      780

gcaacatctg tgtgcaccag gcctgttatg gaatcctcaa ggtaccagag ggcagctggc      840

tgtgccggac atgtgccctg ggggttcagc caaaatgtct gctgtgtccg aagaagggtg      900

gagctatgaa gcccacccgt agcggaacca agtgggtcca cgttagctgt gctctgtgga      960

tccctgaggt gagcattggc agcccagaga agatggagcc catcaccaag gtgtcacaca     1020

ttcccagcag ccggtgggcg ctagtgtgca gcctctgcaa tgagaagttt ggggcctcta     1080

tacagtgctc tgtgaagaac tgccgcacag ccttccatgt gacctgtgct tttgaccggg     1140

gcctggagat gaagaccatc ttagcagaga atgatgaagt caagttcaag tcctattgcc     1200

caaagcacag ctcacatagg aaacccgagg agagtcttgg caagggggct gcacaggaga     1260

atggggcccc tgagtgttcc ccccggaatc cgctggagcc ctttgccagc cttgagcaga     1320

accgggagga ggcccaccgg gtgagtgtcc gtaagcagaa gctgcagcag ttggaggatg     1380

agttctacac cttcgtcaac ctgctggatg ttgccagggc tctgcggctg cctgaggaag     1440

tagtggattt cctgtaccag tactggaagt tgaagaggaa ggtcaacttc aacaagcccc     1500

tgatcacccc aaagaaagat gaagaggaca atctagccaa gcgggagcag gatgtcttat     1560

ttaggaggct gcagctgttc acgcacctgc ggcaggacct ggagagggta atgattgaca     1620

ctgacacctt atagtgactt agagaagaag atgcaaagag gcgaacgctc gcccagagca     1680

agaaatgata gccagtcata tactctcaga cccttgtaca caccacagca tgaggttgtg     1740

ttggttaaaa atatttatgg gctggtaaac tcattgtaca tatgtgcaaa actgctactg     1800

agtggggagc ttctttgtgg tttttttttt tttaaaaaca ctttcccatt aatctttact     1860

gttttgtaag atcaaatggg gtgtgtcttc cccaccccca ttccttcatt ctagagctag     1920

agtgaatgag ccccaagaaa atgacccaag gagttgactc aggatggttt acagactgat     1980

ttagaaaacc agaacggatt tcatttctaa tggagggggc cagagatggg aaaatttctt     2040

gttcagtccg gggaaacaca cctaggtgct ggtgatgggc ttatgaagga agctaagcac     2100

ggctgctcac tggcccccac tttgtttctt gggtaattca caggggaatt cccagtactg     2160

tcatggagca gagcaggcag tgggtgctga tgtgtgtgca tgagctgtat gtacacatgc     2220

atatatctgt tacagaagat actcctggca gtgaggtgct aagtcatcac tgaggctgtg     2280

tgtgtgtgtg tgtgtgcgcg tgcccgtgtc catccatgtc tctgttgtgt gtctgtgtgc     2340

gggtatgggt gggattcctg gtggacaggg gtgtcagatc tgtctgagga gccccagtca     2400

tgctcagcac gctacagatg tgttgtttgt cacactgaga ttgctgaatg tcgtggctgt     2460

tggctgccga gcctcagctg ctggcatttc cttctgctgt ttgctgcttt tgtgcctccc     2520

ccactttcca tcacctctgg agtcccgtct ggacgtccct tcctgctaca ggaataatga     2580

ggcgtgggct gcctcccgct agggcctcct gctccctgta ggtagtttct ggctgaggct     2640

tgctaattgg ggatgcttct tagagcatct tccacatcaa ctcccctggc tgctggctac     2700

cgattaaatt cattagtgtg aaagaggtgg gagtgaggtt ttctggcctg aagcagtctg     2760

cactgaaagg tacccaagtg gcctgaaaca gtgtagggaa agacctggga aacactggac     2820

caaaaaagcc tgatctcatg gagacctgca tggccctgtt agagatggcg tagaagtgaa     2880

agtcttaaag ggagcattag agatcctttt aatacacgac tgagtgccag cttatttgtg     2940

atgccccttc ccagaccagg ttaggattcc tgggaaggcc gcggattccg gccctggaag     3000

aggcaggatc ctggagcagt tttgtgaggc ttttgtgctc ccatacgccc cctggtggtg     3060

agtgtaaaga agactttgcc tctcacaact acatgtatgt gtggcatttt tgttagagat     3120

gagaaaagga ttgagaagga taaactggaa tcctggtaag aagcctttat gccagcccga     3180

cacctgctgt aattggggtg catgagctat ggagtcagat agttgttggg agggggagga     3240

caagaagtct attgtttgga ctgtgtttgt ctcacaatca ccacaaaata aaagtgtaga     3300

aaatgcttgt ggtgtactaa ctcttttctg tacttaagtt actcagatta acatgcactt     3360

ctaattctaa acattttttt tggagtcatc actgtcgctg tttaagtaga acaatgccaa     3420

cgatgtatga gaaacaggga ataaatcagg atttgtgtgt gtatgtgtgt ggcattactt     3480

acatttactt tattaaaaag cctaaggaac tttaaagaat ttgtattcag tttattttta     3540

ttttttcaag acagagtctc actttgttgc ccaggctgga gtgcagtggc gtgatctcgg     3600

ctcactgcag cctccgcctc ccgggttcaa gtgattctcc tgcctcggtc tcatgagtag     3660

ctgggattac aggcgtgcgc caccatgcct ggctaatttt tgtattttta gtagagacgg     3720

tttcaccatg ttggtcaggt tggtcttgaa ctcctgacct caagtgatct acctgtcttg     3780

gcctcccaga gtgttgggat tacgccactg tacccagcct tagactcagt ttaaaatggg     3840

cttattgtaa tgaaaaaaaa tacgctaccc aaaatttgcc atgatgcctg tgatggtgaa     3900

ggcattaaac aattgaaatc tttgccttgc ccagagagtt gcagttattt gtaattataa     3960

acagtaagtg tatcagggca ggggtgacaa taaaaaacca atcattacta cc             4012


<210> 2747
<211> 957
<212> DNA
<213> Homo sapiens

<400> 2747
attctcatcc ctgtgctcag agctctcaag cacccacgat ggccttctca ggccgagcgc       60

gcccctgcat tatcccagag aacgaagaaa tcccccgagc agcccttaac actgtccacg      120

aggccaatgg gaccgaggac gagagggctg tttccaaact gcagcgcagg cacagtgacg      180

tgaaagtcta caaggagttc tgtgactttt atgcgaaatt caacatggcc aacgccctgg      240

ccagcgccac ttgcgagcgc tgcaagggcg gctttgcgcc cgctgagacg atcgtgaaca      300

gtaatgggga gctgtaccat gagcagtgtt tcgtgtgcgc tcagtgcttc cagcagttcc      360

cagaaggact cttctatgag gaacgaacgt gatggttaag ctaccttcat taagcagcat      420

gaccgcttcc tgagctcctg ctgccgcatt taggccctgt cagctgtgag gccactggtg      480

ctgagtcaga gggaaaagct cagaacagcc ttgagcagcg aagaataaag catgactcat      540

ctcgtcctgc ccacccctca cactggacta taaataccct ccctgggtct gtgtgctgtt      600

attccaaaag atgcgatgaa tacccagaac taggctattc atgggctgtt gcccagttca      660

agctctattg ggtcctgagg aagattacta ttttggctac attgtttatc attaaaacca      720

gcccagggat gtgtaaacct gcatctggag aataagacat ttctttttgg ttaaatgata      780

ttagagaaaa aaaaaactat ccaaggctgc taacaaataa tcttcacttt caattatatc      840

cagcaataag ttgttctcca gaaaagaaag cttggaaact tacccagttt gccttccatt      900

tgggacatga ctgatgtgct tcagtctttg tataataaat gcatcttcgc cactcta         957


<210> 2748
<211> 1520
<212> DNA
<213> Homo sapiens

<400> 2748
agtcataaag gtctctttgc caagttactg ccctctcaag ctgcttccag tgaatgctac       60

acacctgcac catggtttgt ccgacatcct tagccaagat caggattggc tatgttggta      120

cttacatatc ctcatgagaa ttgtggttct ggtactagtt tggtaaagaa attattaaac      180

ctagctgatg cttgaaggta gttggattaa caggaaagaa aagagacttc ttttctagcc      240

aagatgaaag atacacaaga cattcaggaa gcttcgaagg caatgcagaa taaagtccat      300

gagcaggaag ataagaatga gaaacaaaaa caaagagaag acaaacttgg agtatattct      360

ttagtacatt tttccccaaa gatgttgggt tcagttgcca caacactgcc attgtcatct      420

tcaaattcca gtggaatgcc tcttggttac tatctgtcta gtcctcagat tagtagagta      480

actatatcaa caactggaca attgacttct aaagctactg taggtagctg ttccagagtg      540

gaaaacagct tggatgccag ccccttctca gttccgaaga aacaggatga atcacccatg      600

attggggatg gagaagatta tttcctttct ttgtttggtg attcaaagaa acttacagca      660

cactcaaact acactcagaa aactttaaaa tacttttcta tgattcttga agaagttggc      720

caatttacct ccagttctct tggagatgtt gaaatagctg aagtgaatgt caagggtttg      780

ttcgtgaagc tcattaactc ttcccttgac aaagaaatgg caattggaga tcatattctc      840

cagcaaaatg tgaatggaca aaccatttct ttgtaccgat tccttccaaa catcgtaatg      900

caggcaaatt ccacagtaac agccattgcg tggtacaccc ctatccactg gaagcaagcg      960

tgggaaaaat tagatgctga cgttgaattt aacagatgtt cagtagtatc tccaacattc     1020

cgaaagcgtg tgtttcagtg gacagcatct acagctacaa taactaaaga aaaacaagat     1080

caacctaaga aagatatctc aaattatcag gtggaacaag ctcaagttct tcttaagaga     1140

gagaaggaaa tcccaccaac cgttttccct aatcgcagcc cttggtgcca gaatccctat     1200

gtctctgcac atccttactg tcctctgatt gaaccacaca atacatccac cgctggaggc     1260

agattggata gacagcccag gactcggtca accagaccta atcgagcctc agggtctaag     1320

aaaaagaaga catctgagtc acaaaagcaa taagcagtca actcaacctt taaagcttta     1380

cctttatggt gtcatggtcc agttgtatgg aagagtaaaa agacctgcaa tctaggctcc     1440

ctgccatgct ggccaaagac attccacaac ttaaagaaaa tcaaatgcct gagcaaacgt     1500

agcgggttcc gctttcatag                                                 1520


<210> 2749
<211> 1158
<212> DNA
<213> Homo sapiens

<400> 2749
acgtcagagg gtcgcgccgc tgcaggaacc cgctctgcct gagctaccgc gagtcgtaga       60

aaattacgta atgatagggg gccggtcaga gtgagggcac ctgaggtaca cgaaatccct      120

ccggcttgcc cacttcctcg gactttccac caatcaggag cttcctcccc agcaccaacc      180

aattgtggga gagaagtttt ctctgtgcta caagcccgga atttcattca tacccagcta      240

cgctccgaat gagggagcag aggtacagcg gccgaatgag cgggaacagt tattccacga      300

caggtgtaca tcagacgcat tgcttaggcc tcttatttta cgttctccaa gcaactccat      360

aagacaactg tctcggaaag gctacagtga tgacagaccg acttaagttc ggattcggct      420

tccaccgctt cttagtggta tgcaaagaag ccttttcacc ctgatgtcct tagagataat      480

atggatcagt ccagagttct cctctgggtg aaagcagaac cctttatagt gggtgccttg      540

caggtccccc ctccatccaa gtttagtctt cactatctca ggaagatatc cacctatgtg      600

caaatccggg ccacagaagg agcttacccg cgcctctact ggtctacatg gaggcacatc      660

gcttgtggga agctgcagtt ggccaaggac ctggcgtggc tttacttcga aatatttgat      720

agtctttcaa tgaagacacc tgaggagcgc ctggaatggt ctgaggttct gtccaactgc      780

atgtctgagg aggaagttga aaagcagaga aatcagcttt cagtggacac gctacagttt      840

ctgctcttct tatacattca acagttgaac aaggtctccc taaggacatc tttgattggc      900

gaagagtggc ccagtcccag aaacaaatct cagtctcctg acctgactga aaaatctaat      960

tgtcataata agaactggaa tgattacagt caccaagctt ttgtctatga tcatctgtct     1020

gatctcctcg agctgctttt agatccaaaa caactcactg catcatttca ttcaacccat     1080

agtagtctag tgtctcgaga agctgttgtg gcgctcagct tccttattga aggtacaata     1140

agtagagcca ggaagatc                                                   1158


<210> 2750
<211> 1287
<212> DNA
<213> Homo sapiens

<400> 2750
gaactcaagg cctgcttgat acgtccgcca ttttgggcgc ttcgctgatg gtgtcggtga       60

gcgcgtttcc cgcctgagcg caactagcgg cgggtcgtgg gcacctccag gagagcttgt      120

ttcatatcca tatcccactg tattcctgct aatctgctaa tgcagtaaat tggaggaaaa      180

ctgttaccag gataacctgt aatgggcaag gagccacaaa gaagaaaaca tttcttttaa      240

tttttaaact tggtttgaaa gaccagcatg ttttggaaat ttgatcttca ctcatcatcc      300

cacatagaca cacttctaga aagagaagat gtaacactga aggagttaat ggatgaggaa      360

gatgttttac aggaatgtaa agctcagaac cgcaaactta tagagtttct gttaaaagca      420

gaatgtctcg aagatttagt ctcattcatt atagaagaac cacctcaaga catggatgaa      480

aagatcagat acaagtatcc aaatatatct tgtgagttgc tcacttctga tgtctcccag      540

atgaatgata gactgggaga agatgaatcc ttgctaatga aattatatag cttcctccta      600

aacgattccc ctttgaatcc actacttgcc agtttcttca gcaaggtgct aagtattctt      660

atcagcagaa aaccagaaca gattgtggat ttcttaaaga agaagcatga ttttgtagac      720

cttattataa agcacatagg aacttctgct atcatggatt tgttgctcag gctcctgacg      780

tgtatcgaac ctccacagcc caggcaagat gtgctgaatt ggttaaatga ggagaaaatt      840

atccagaggc ttgtggaaat agttcatcca tcgcaagaag aagatcgaca ttcaaatgca      900

tcacaatcac tttgtgaaat tgttcgcctg agcagagacc agatgttaca aattcagaac      960

agtacagagc ccgacctcct gcttgcctca gggctgcctg acttgaatgg cgttggacct     1020

cggggattac tggtagataa tatgctctgg tctcgcctgg tggtgagttt tgccagccat     1080

ggccagggtt tggctccact ggtggcacac gtggcctccg tggtatggac ctggtggctt     1140

ctccatccca ctgtggcctc tgtggtatgg acctggtggc ttctccatcc tacccaaggt     1200

aacagtgtct tgcttcatcc cactgactgc tgggagagag cctctgggac ttttctttgg     1260

ggcatcattt tgttttgtct ttcgtag                                         1287


<210> 2751
<211> 2472
<212> DNA
<213> Homo sapiens

<400> 2751
actctggctg ccttctcctg agagtcggag ccacagccag agccctgccc aggccgagcc       60

ggagctgcag cccgagcgcg gtggtgccct cagccccgtc ctcttgtcct cctcagcctc      120

gatctgccgg aggcgctggg caatgacccc gggactccag gccagagggg tctgaagctg      180

tttgggaaag cagcgggact ccttgggaag atggccatgg ccccaagccc ttccctggtg      240

caggtgtaca ccagccccgc ggctgtggcc gtgtgggaat ggcaggacgg gctgggcacc      300

tggcacccct acagtgccac cgtctgcagc ttcatcgagc agcagtttgt ccagcagaag      360

ggccaacgtt ttgggcttgg gagcctggcc cacagcatcc ccttgggcca ggcagacccc      420

tcgctggccc cttacattat tgacctcccc agctggaccc agttccgcca ggacaccggc      480

accatgcggg ctgtgcggag acacctgttc ccccagcact cagcccctgg ccgaggtgtc      540

gtctgggagt ggctgagcga cgatggctcc tggactgcct atgaagccag cgtctgtgac      600

tatctggagc agcaggtggc caggggcaac cagctcgtgg acttggcccc cctggggtac      660

aactacactg tcaactacac cacccacacg cagaccaaca agacttccag cttctgccgc      720

agcgtgcggc gccaagcagg gccgccttac ccggtgacca ccatcatcgc tccgccgggc      780

cacacaggcg tcgcctgctc ttgccaccag tgcctcagtg gcagcagaac tggccccgtg      840

tcaggccgct accgccactc catgaccaac ctccctgcat accccgtccc ccagcacccc      900

ccacacagga ccgcttctgt gtttgggacc caccaggcct ttgcaccgta caacaaaccc      960

tcactctccg gggcccggtc tgcgcccagg ctgaacacca ccaacgcctg gggcgcagct     1020

cctccttccc tggggagcca gcccctctac cgctccagcc tctcccacct gggaccgcag     1080

cacctgcccc caggatcctc cacctccggt gcagtcagtg cctccctccc cagcggtccc     1140

tcaagcagcc cagggagcgt ccctgccact gtgcccatgc agatgccaaa gcccagcaga     1200

gtccagcagg cgctcgcagg catgacgagt gttctgatgt cagccattgg actccctgtg     1260

tgtcttagcc gcgcacccca gcccaccagc cctcccgcct cccgtctggc ttccaaaagt     1320

cacggctcag ttaagagatt gaggaaaatg tccgtgaaag gagcgacccc gaagccagag     1380

ccagagccag agcaggtcat aaaaaactac acggaagagc tgaaagtgcc cccagatgag     1440

gactgcatca tctgcatgga gaagctgtcc acagcgtctg gatacagcga tgtgactgac     1500

agcaaggcaa tcgggtccct agctgtgggc cacctcacca agtgcagcca tgccttccac     1560

ctgctgtgcc tcctggccat gtactgcaac ggcaataagg atggaagtct gcagtgtccc     1620

tcctgcaaaa ccatctatgg agagaagacg gggacccagc cccagggaaa gatggaggta     1680

ttacggttcc agatgtcgct ccccggccac gaggactgcg ggaccatcct catagtttac     1740

agcattcccc atggtatcca gggccctgag caccccaatc ccggaaagcc gttcactgcc     1800

agagggtttc cccgccagtg ctaccttcca gacaacgccc agggccgcaa ggtcctagag     1860

ctcctgaagg tggcctggaa gaggcggctc atcttcacag tgggcacgtc cagcaccacg     1920

ggtgagacgg acaccgtggt atggaacgag atccaccaca agacagagat ggaccgcaac     1980

attacgggcc acggctatcc cgaccccaac tacctgcaga acgtgctggc tgagctggct     2040

gcccaggggg tgaccgagga ctgcctggag cagcagtgac ctcgcacccc agcacgcccg     2100

cctctggtgg ccaccccgct gccccatggc tggctgggtg gccaggcagg aagtgcccag     2160

cccgagaggc tgggaggttt gttgagggtg tggggtgtgc cccacctgaa gccggggctc     2220

cccctgcctg cctctctctc ctcctcccct ctgggaattg ggcagccctg ggcagttgta     2280

ctcatggggg cttaggatgc agctacctca gtgcgcaggg cccgtctgtc ctctgggggc     2340

tgcttcgggc ccgcggtgct cggggcctgg tgtggggcga gtagagactt ccccagcctg     2400

gacgggcgtg ggttctgggt cagcttcttt tacctcaatt ttgtttgcaa taaatgctct     2460

atagccaaag cc                                                         2472


<210> 2752
<211> 4455
<212> DNA
<213> Homo sapiens

<400> 2752
agagcgaagc tgaggagtcc agcgctcgcc gacaggggcc tgggctgtcc cgagccggaa       60

tccagatctt acataagatg gaagtctctc acactagata ctgaacatta aatagaaaat      120

ctatttagta aaatctaagt tgccatggaa gaaataccag taaaagttgc tgtaagaatt      180

agacctctgc tttgcaaaga agctcttcat aatcatcaag tttgtgtgag agttattcca      240

aacagccagc aagttatcat tgggagagat agagtcttca cttttgattt tgtttttggc      300

aaaaattcca ctcaagatga agtttataac acatgtataa agcccctagt gttgtcactc      360

attgagggct ataatgcaac tgtttttgcc tatggacaaa ctggatctgg gaagacatac      420

accattggag ggggccatat tgcttcagtt gtggagggcc aaaagggtat cattcctcga      480

gctattcaag aaatatttca aagcatctct gaacatccta gcattgactt taatgtaaaa      540

gtatcttata tagaagtgta caaggaagac ctaagagatc ttctagaatt ggagacatcc      600

atgaaggatc ttcacatccg agaagatgaa aaaggaaaca cagtgattgt tggggccaag      660

gaatgccatg tggagagtgc aggtgaagtg atgagtcttt tggagatggg gaatgcagcc      720

agacatacag gtaccactca aatgaatgag cactccagca gatcacatgc aatttttaca      780

atcagcattt gtcaagttca taaaaatatg gaggcagctg aagatggatc atggtattcc      840

cctcggcata ttgtctcaaa gttccacttt gtggatttgg caggatcaga aagagtaacc      900

aaaacgggga atactggtga acggttcaaa gaatccattc aaatcaatag tggattgctg      960

gctttaggaa atgtaataag cgctcttggg gacccacgca ggaagagttc acatattcca     1020

tatagggatg ctaaaattac ccggcttctg aaagattctc tgggaggcag tgctaagact     1080

gtcatgatca catgtgtcag cccctcctcc tcgaattttg atgagtcctt aaattctctc     1140

aaatatgcca acagagcacg gaacattaga aacaaaccca ctgtaaactt cagccccgag     1200

tcagaccgta tagatgaaat ggaatttgag attaaattgc ttcgagaagc tttgcaaagc     1260

cagcaggctg gtgtcagcca aactacccag atcaatcgag aagggagtcc tgatacaaat     1320

aggattcatt ctcttgagga gcaagtagct cagcttcaag gagaatgtct gggttaccag     1380

tgttgtgtag aagaagcctt taccttcctg gttgacctaa aagatactgt cagactaaac     1440

gaaaagcagc aacacaaact gcaggagtgg tttaacatga tccaagaggt caggaaggct     1500

gtcctcacct catttcgagg aatcggaggc actgcaagtc tggaagaagg accacagcat     1560

gttacagttc tccagctgaa gagagagctt aagaaatgcc agtgtgtgct tgctgctgat     1620

gaagtagtat ttaatcagaa ggaactggag gtgaaggaac tgaagaatca agtgcagatg     1680

atggtacagg aaaacaaagg gcatgctgta tctttgaaag aagcgcaaaa agtgaataga     1740

ctgcagaatg aaaaaataat agaacaacaa cttcttgtgg atcaactgag tgaagaacta     1800

acaaaactta acctgtcagt gacttcttca gctaaagaaa attgtggaga tgggccagat     1860

gccaggatcc ctgaaaggag accatatact gtaccatttg atactcattt ggggcattat     1920

atttatatcc catcaagaca agattccagg aaggtccaca caagtccgcc tatgtactct     1980

ctggatcgaa tatttgctgg atttcgaaca cgaagtcaga tgctgttggg tcacatagaa     2040

gaacaagata aggtcctcca ctgccaattt tctgataaca gtgatgatga agaatcagaa     2100

ggccaagaga aatctggaac tagatgtaga agtcgttcat ggattcagaa gccagactct     2160

gtttgttccc ttgttgaatt gagtgatact caggatgaaa cacaaaagtc agatttggag     2220

aatgaagatt taaagattga ttgtctccag gagagtcaag aattgaattt gcaaaaatta     2280

aagaattcag aacgcatact tactgaagct aaacaaaaaa tgagagaact tacaattaac     2340

atcaagatga aggaagatct gattaaagaa ttaataaaaa caggtaatga tgccaagtct     2400

gtaagcaagc agtattcttt gaaagtaaca aagctagagc atgatgcaga acaggcaaaa     2460

gtcgaactga ttgaaacaca aaagcagcta caggagctgg aaaacaaaga tctttctgat     2520

gttgcaatga aggtaaaatt acagaaagag tttcgtaaaa agatggatgc tgcaaagctg     2580

agagttcagg aaatacaatt aaaaacagga caggaagaag gtctaaaacc gaaagctgag     2640

gaccttgatg catgtaactt gaaaaggaga aaaggttcgt ttggaagtat agaccatctc     2700

cagaaattgg atgagcaaaa gaaatggtta gatgaagaag tagagaaagt tctgaaccaa     2760

cgccaagaat tagaggagct ggaagcagac ttaaagaaac gggaggccat agtttctaag     2820

aaggaggctc tgttacagga gaagagtcac ctggaaaata agaaattgag atctagtcag     2880

gccttaaaca cagatagttt gaaaatatca actcgcctga acttactgga acaagagttg     2940

tctgaaaaga atgtgcagct ccagaccagt acagctgagg agaaaacaaa gatttcagaa     3000

caagttgaag tcctccagaa agaaaaggat cagctccaga aacgcagaca caatgtggat     3060

gaaaaactta aaaatggtag agtgttatca cctgaagaag aacatgttct tttccaactt     3120

gaagaaggga ttgaagcttt ggaagctgca attgaataca ggaatgaaag tatccagaat     3180

cgccagaagt cacttagagc atcattccat aacctctctc gtggtgaagc aaatgtcttg     3240

gaaaagctag cttgcctgag tcctgttgag attagaacta ttcttttcag atatttcaat     3300

aaggtggtga atttgcgaga agctgaacgg aaacaacagt tatataatga agaaatgaaa     3360

atgaaagttc tggaacggga taatatggtt cgtgaattag aatctgcact ggaccatcta     3420

aaattgcagt gtgaccggag actgaccctc cagcaaaagg aacacgaaca aaagatgcag     3480

ttgctattac atcatttcaa agaacaagat ggagaaggca ttatggaaac tttcaaaaca     3540

tatgaagata aaatccagca gttggaaaaa gatctttatt tctataagaa aaccagccgg     3600

gatcataaga agaaacttaa ggaactggta ggggaagcaa ttcggcggca actagcacca     3660

tcagagtatc aagaggctgg agatggagtc ctgaagccag aaggaggagg catgctttca     3720

gaagaattaa aatgggcatc cagacctgaa agtatgaaat taagtggaag agaaagagaa     3780

atggacagtt cagcaagcag cttaagaaca cagccaaatc ctcaaaagct ctgggaagat     3840

atcccagaat tacctccaat tcatagttct ttagcacccc ccagtgggca tatgttaggt     3900

aatgagaata aaacagaaac agatgataat cagtttacaa aatctcacag tcgactgtca     3960

tcccaaattc aggttgtggg aaatgtggga cgacttcatg gtgtcacacc tgtaaaactg     4020

tgtcgaaaag aattacgtca aatttccgcc ttggaactat cattgcgacg ttccagtctt     4080

ggagttggca ttggatcaat ggctgctgat tccatcgaag tatctaggaa accaagggac     4140

ttaaaaactt agacattgaa taatagaact tttagtagat atgtaaaaag attccttttt     4200

ctaacctgtt aaaaactaaa gctcaagttc actacctctt tcctcagaat aaaggaagaa     4260

ggggaggaag gaatccctaa ttcttttata tgctatagat gtgtacatct tctatatata     4320

tttggggagt tttagtttat attcccatag taatcaaaca tgttttccaa tacttgataa     4380

catttaaata tttataaata cgcttaaatg tttttccagg catatttgaa gattaaaact     4440

agtaatagac taaaa                                                      4455


<210> 2753
<211> 2967
<212> DNA
<213> Homo sapiens

<400> 2753
cgtgactgaa ctcgaggagg acctgggcac ggcccgccgg gacctcatca agtcggagga       60

gctgagcagc aagcatcagc gggacctccg ggaggctctg gcccagaagg aggacatgga      120

agagcggatt actacactgg agaagcgcta cctggctgct cagcgtgagg caacatccat      180

ccatgacctc aatgacaagc tggagaatga gctggccaac aaggagtccc tgcaccgcca      240

gtgtgaggag aaggcccgac acctgcagga gctgctggag gtggcagagc agaagctgca      300

gcagacgatg cgcaaggcag agacgctgcc agaggtggag gctgagctgg cccagagaat      360

tgcagccctc accaaggctg aagaacggca tggcaacatt gaggagcacc tgcggcagct      420

ggagggacag ctggaggaga agaaccagga gctggcacgg gtgcgccagc gggaaaagat      480

gaatgaggac cacaacaagc ggctgtcgga cacagtggac cggctgctca gcgagtccaa      540

cgagcgtctg cagctccacc tgaaggagcg catggctgcc ctggaggaga agaacacgtt      600

gatccaggag ttggagagct cccagcggca gattgaggag cagcaccacc acaagggccg      660

cctgtctgaa gagattgaga agctgcgcca agaggtggac cagctgaagg gccgaggggg      720

gccgtttgtg gatggcgtcc actccaggtc gcacatgggc agtgcagcag acgtgcggtt      780

ctccctgggc acaaccacac acgcaccccc aggcgtgcat cgccgctact cggcattgag      840

ggaagagtct gccaaggact gggagacttc tccactgcct gggatgctgg ccccggcagc      900

tggccctgcc tttgacagtg accctgagat ctccgacgtg gatgaggatg agccaggggg      960

tctggtgggc tctgcggatg ttgtctcccc cagcggccac tcagatgccc agaccctggc     1020

catgatgctg caggagcagc tggatgccat caatgaggaa atcaggatga ttcaggaaga     1080

gaaggagtcc acggagctcc gcgcggagga gattgagacg cgtgtaacca gtggcagcat     1140

ggaagcccta aacctgaagc agctgcgcaa gcgtggttcc atccccacct ctctgacggc     1200

cctgtccctg gccagcgcgt ccccaccact cagcggccgc tccacaccta agctcacctc     1260

ccgcagtgct gcccaggacc tggaccgaat gggggtcatg accctgccca gtgacttaag     1320

aaagcatagg aggaagctgc tgtcgccagt gtctcgggaa gagaaccgag aggataaagc     1380

caccataaaa tgtgagactt ctcctccttc ctcacccagg acgctgcggc tagagaagct     1440

tggccaccca gccctgagcc aggaagaagg caagagtgcc ttggaggatc agggcagcaa     1500

ccccagcagc agcaacagca gccaggactc cctgcacaag ggcgccaagc gcaagggcat     1560

caagtcgtcc attggccgcc tgtttgggaa gaaggagaag ggcaggctga tccagctgag     1620

tcgggatgga gccacaggcc atgttctgct aacagactcc gaattcagta tgcaggagcc     1680

tatggtgcct gccaagctgg ggacccaggc agagaaggac cggcggctaa agaagaaaca     1740

ccagctgctt gaagatgccc gcaggaaagg aatgcccttt gcccagtggg atggtcctac     1800

tgtggtctcc tggttggagc tctgggtggg gatgcctgcc tggtatgtgg cagcctgccg     1860

ggccaacgtc aagagtggtg ccatcatgtc cgctctgtcg gacacagaga tccagcggga     1920

gatcggcatc agcaatgccc tgcaccggct caagctccgc ctggccattc aggagatggt     1980

gtcattgacc agcccctctg ccccacccac ctccaggact tcttctggga atgtctgggt     2040

cacccatgaa gagatggaaa ctctggaaac atctactaaa acagacagtg aggagggcag     2100

ctgggctcag accctggcct atggggacat gaaccatgag tggattggga atgaatggct     2160

acccagcctg gggctcccgc agtaccgcag ctacttcatg gagtgcctgg tggacgcccg     2220

catgctggac cacctcacca agaaggacct gcgggtccac ctgaagatgg tggacagctt     2280

ccatcgaacc agtcttcagt atggcatcat gtgtctgaag aggctgaatt atgaccggaa     2340

ggagctggag aagaggcgag aggagagcca gcatgagatc aaggatgtgt tagtctggac     2400

caacgaccag gtggttcatt gggtccagtc tattgggctc cgggactacg caggaaacct     2460

gcatgagagt ggtgtgcatg gagccttgct ggccctggac gagaacttcg accacaacac     2520

actggccctg atcctccaga tccccacaca gaacacccag gcacgccaag tgatggaaag     2580

agagttcaat aacctgttgg ccttgggcac agaccggaag ctggatgacg gggatgacaa     2640

ggtgtttcgc cgcgcgccct cctggaggaa gcgcttccgg ccgcgggagc accacggtcg     2700

cggcggcatg ctcagcgctt ccgcggagac cctcccggcg ggcttccgtg tgtccaccct     2760

ggggaccctg cagcccccac cggccccgcc aaagaagatc atgcctgaag ctcactccca     2820

ctatctctac ggacacatgc tctccgcctt ccgggactag ccatggcccc cagggctggc     2880

ttcctccttc tgggtttcac aggctcctct ggccctgacc cctcttgctc gttccccttc     2940

cttccgcagc tcctagtctc gtccgtg                                         2967


<210> 2754
<211> 2815
<212> DNA
<213> Homo sapiens

<400> 2754
gacgtcggcg gtgacaggcc ctgggactct gggaataccc agcttcctcc ccgcaacccg       60

gtgaaagcca acgcaatgtt cggtgcgggg gacgaggacg acaccgattt cctctcgccg      120

agcggcggtg ccagattggc ctcacttttt ggactggatc aggcagctgc tggccatgga      180

aatgaatttt tccagtacac agccccaaaa cagcctaaga aaggccaggg aacggcagca      240

acaggaaatc aggcaacacc aaaaacagca ccagccacca tgagcactcc cacaatactg      300

gtcgcaacag cagtccatgc atatcgatac acaaatggtc aatatgtaaa gcagggcaaa      360

tttggtgctg cagttctggg gaaccacaca gccagagagt ataggattct tctttatatc      420

agtcaacaac agccagttac ggttgctagg attcatgtga actttgagct aatggttcgg      480

cccaataact atagcacctt ttatgatgac cagagacaga actggtccat catgtttgag      540

tcggaaaagg ctgctgtgga gttcaataag caggtgtgca ttgctaagtg caacagtacc      600

tcttccctgg atgcagtgct ctcccaggac ctcattgtgg cagacggccc tgctgtagaa      660

gttggagatt ctttggaagt ggcctatacc ggctggctct ttcagaatca tgtgctgggc      720

caggttttcg actccactgc taacaaagat aagttgcttc gcttgaagtt aggatcagga      780

aaagtcatca agggctggga ggatggaatg ctgggcatga aaaaaggagg aaagcgattg      840

cttattgtcc ctccagcctg tgctgttggc tcagaagggg taataggctg gactcaagca      900

acggactcga tcctggtgtt cgaggtggag gttaggcggg tgaagtttgc cagagattct      960

ggctctgatg gtcacagtgt tagttcccgc gattctgcag ctccgtctcc catccctggt     1020

gctgacaacc tctctgctga tcctgttgtg tcaccaccca catcaatacc tttcaaatca     1080

ggggagccag ctcttcgtac caaatctaac tccctcagtg aacaacttgc aataaataca     1140

agtcccgatg cagtcaaagc caagttgatc tctcggatgg ctaaaatggg ccagcccatg     1200

ctgcccatcc ttccaccaca gctggattcc aatgattcag aaatcgaaga tgtgaacact     1260

ctgcaaggag gtgggcagcc tgtggtgact ccgtccgtcc agccctctct tcatccggcc     1320

catccagcgt taccacagat gacctcacag gcacctcagc catctgttac tgggctccag     1380

gcaccttctg ctgccttaat gcaagtgtca tctctcgatt cccactcagc tgtatctgga     1440

aatgcccaat cctttcaggt aacattttat aaccgtatta attatatcct ataatttgct     1500

gtggttctag tcagtctctt ttcttcttcc tgtacatttc atacagtagc agttccccaa     1560

agtcagagtt tgtaattttt ttcccttcct tggttaccac tttctcatct ctaaaccagg     1620

caaaggataa cctacgttcc agtgtcataa agattaaatg caagaacaag tagagcccct     1680

agtacaacgt agtaaagatg caatcaatgt ttgtttcctt ttcttttcac acatatccag     1740

ttgaagcgtg tatattcgcg ttcttctgta ttcttttcta ctaaaagttg gcaggctaac     1800

attctgcagt atattcagca gaatggtatg gtttaaaagt ggaaccatgt ggaaaatgta     1860

gcttgactct gctatctagt aaacttttct taaagaaggc ctttttcctg ttatcacaga     1920

aaacaatggc agcagcctgt ttgccagggg tagcagaccc tttcttctgc ctcaacacac     1980

ttggtggata aggcatactg tcactgggaa cagctgctca ctccttgtga tgcttaatgg     2040

aggtgtggga atgatggtgg ataggctatg cctcattaac atggggagtc tcgaaactgg     2100

aaaaagtccc actgttgccc tctttctccc catccctcct ctcctccatg gagaattact     2160

atgctgtaga ctaagaattt tttttaagtg gatgcgtagt tatatctatc cctggaaatg     2220

agctagactt ccttatttca aggaagaatt accatcctca ttaaaataaa agctgctgtt     2280

tattaagcgc ttactatctg tcaggcctgt aacttactag cttttcagaa ctttacctat     2340

ctcacttcat ttagtccaca gaacagccct atgaagtgat attattatct tcctcttaca     2400

gttgaggtga ccgagactca aaggaacatg agagctcttg gtctcgtgga ttagcttcag     2460

aatctagcag gggagaggca tccttggaaa ttggcagatt tggtttggaa tctcagtgag     2520

cacttcttct ttaaactcaa tggaagctaa gcagagttta ttaatctaaa aacttcttag     2580

acaataggcc tgataatggg gaatgaatcc ctgcttaatt atctcaccag atgactgggt     2640

agtgacctaa gatacacttt cttcagtttc tgggtaggat tttagtgact ggtttcccct     2700

gggatacata gataactctc ctgctgcagt ccttaccaac tgccaaaccc agatctcacc     2760

catctctagc ttcagtaagt ttgagtctcc tcccagctca tccactttat tccac          2815


<210> 2755
<211> 566
<212> DNA
<213> Homo sapiens

<400> 2755
acagtctcag ggatgagcag ccgcccaagc tgcagggcct cgggtcttcg gcgcctctga       60

ccctcgcagg ttgctgcctt tcggtgcaga accgtctctg aaagaagatg aatttggctg      120

agatttgtga taatgcaaag aaaggaagag aatatgccct tcttggaaat tacgactcat      180

caatggtata ttaccagggg gtgatgcagc agattcagag acattgccag tcagtcagag      240

atccagctat caaaggcaaa tggcaacagg ttcggcagga attattggag gaatatgaac      300

aagttaaaag tattgtcagc actttagaaa gttttaaaat tgacaagcct ccagatttcc      360

ctgtgtcctg tcaagatgaa ccatttagag atcctgctgt ttggccaccc cctgttcctg      420

cagaacacag agctccacct cagatcaggc gtcccaatcg agaagtaaga cctctgagga      480

aagaaatggc aggagtagga gcccggggac ctgtaggccg agcacatcct atatcaaaga      540

gtgaaaagcc ttctacaagt agggac                                           566


<210> 2756
<211> 1142
<212> DNA
<213> Homo sapiens

<400> 2756
atgttccagg tcccggatag cgagggcggc cgcgccggct ccagggccat gaagccccca       60

ggaggagaat cgagcaatct ttttggaagt ccagaagaag ctactccttc cagcaggcct      120

aataggatgg catctaatat ttttggacca acagaagaac ctcagaacat acccaagagg      180

acaaatcccc cagggggtaa aggaagtggt atctttgacg aatcaacccc cgtgcagact      240

cgacagcacc tgaacccacc tggagggaag accagcgaca tttttgggtc tccggtcact      300

gccacttcac gcttggcaca cccaaacaaa cccaccagaa actcaagaga tagggtagcc      360

atgttttcat ttccttttgc ccaaatgagc ggggtgggaa gagggttagt cttatgtgag      420

cctggctgct cagcgtctcc tggccgtcat gacagctgct tggagacccg tgccttccag      480

atggctggga gatgcctctg tggggatgaa atggggcacc cctggccatc actcatgtgt      540

agtccaggtt tgagaggaac tggaaggggg gtgagggtgg ggaggtgggg cagggcatgg      600

tccttggatc aacagcccgc cagctgattg gatgtctagg aatgactgaa agaaaccaaa      660

acagcctgtc cactgctgct gtgggatgga ggaggcgtaa gcagaaacac taacagtata      720

ttgacctctt agcagaaccg cttccattct ggagatcacg gctgctaaat ccagcatccc      780

cacttcattt tacccccagc atattgttct gtagtctttt cttgaaacat cttgattgct      840

tttcctcggc agctttcaaa aaaccaaata ataatagtta tccgtcttct acttcatgga      900

agattgtttt ggtgccctga ccctctgaag tgcccagttc ctgccatctg aaacctcggc      960

ctgatctgat ctcatgttgg aatctgcctg tctttcacac agggctggtc ttggtccttt     1020

acatgccagt tttgcttgtg aattcttgct tttttcctct catcagcctt aagtttaggc     1080

gtttgttgtt ctccagtgat gtagacagtt cccttcacaa gtcacagttc ttcccataaa     1140

tg                                                                    1142


<210> 2757
<211> 778
<212> DNA
<213> Homo sapiens

<400> 2757
ggccgctccg cccggggccc tagagccagc cggggagctg cagctcagcg gcgcccggca       60

gggtcgggct gggctgggcc cggccgaccc ggggaggggg cggggtcacc ccagcctcac      120

ctctgggcgc ccaggcgctc cgcggggtga gggttcggcg gccactcctg ggactctggg      180

ctgcggtaga tgccgttctc caaggagaag tacatcctgg actcatcgcc agagaaactc      240

cacaaggaat tggaggagga gctcaaactc agcagcacgg atctccgcag ccatgcctgg      300

taccatggcc gcatcccccg agaggtctcg gagaccttgg tacaacgcaa cggcgacttc      360

ctcatccggg actcactcac cagcctgggc gactatgtgc tcacgtgccg ctggcgcaac      420

caggccttgc acttcaagat caacaaggtg gtggtgaagg caggcgagag ctacacacac      480

atccagtacc tgtttgagca ggagagcttt gaccacgtgc ccgccctcgt gcgctatcat      540

gtgggcagcc gcaaggctgt gtcagagcag agtggtgcca tcatctactg cccggtgaac      600

cgcaccttcc cactgcgcta cctcgaggcc agctatggcc tgggacaggg gagtagcaag      660

cctgctagcc ccgtcagccc ctcaggcccc aagggcagcc acatgaagcg gcgcagcgtc      720

accatgaccg atgggctcac tgctgacaag gtcacccgca gcgatggctg ccccacca        778


<210> 2758
<211> 6872
<212> DNA
<213> Homo sapiens

<400> 2758
cggagggagt aggagagccc ggggcttcgg caggcagagc aggcctctcc cctccgtcct       60

cgtcgtcctc gtcctcctcc tcctcctcct cctccgtggt ggtagtggtg ggacttcccc      120

cggctgctgc ccctcccgcc gccgctgctg tcccccaccg aagtagcggc cacagcctgg      180

tcagcggcag catcatgcag gccaatgggg caggaggagg aggaggaggt ggcggcggcg      240

gcggtggagg aggagggggc ggcgggggcc agggacagac cccggaactc gcctgcttgt      300

cggcccagaa cggggagtcg tccccctcgt cgtcgtcgtc cgcgggggac ctggcccacg      360

ccaatgggct cctgccttcc gccccctccg ccgccagcaa caatagcaac agcctgaatg      420

tcaataacgg ggttcccggc ggggcggccg ccgcatcctc agccaccgtc gcagctgcct      480

ccgccaccac cgccgcctcc tcttccttgg ccaccccaga actgggcagc agcctcaaga      540

agaagaagcg gctctcccag tcagatgagg atgtcattag gctaatagga cagcacttga      600

atggcttagg gctcaaccag actgttgatc tcctcatgca agagtcagga tgtcgtttag      660

aacatccttc tgctaccaaa ttccgaaatc atgtcatgga aggagactgg gataaggcag      720

aaaatgacct gaatgaacta aagcctttag tgcattctcc tcatgctatt gtggtaagag      780

gcgcacttga aatctctcaa acgttgttgg gaataattgt gaggatgaag tttttgctgc      840

tgcagcagaa gtacctagaa tacctggagg atggcaaggt cctggaggca cttcaagttc      900

tacgctgtga attgacgccg ctgaaataca atacagagcg cattcatgtt cttagtgggt      960

atctgatgtg tagccatgca gaagacctac gtgcaaaagc agaatgggaa ggcaaaggga     1020

cagcttcccg atctaaacta ttggataaac ttcagaccta tttaccacca tcagtgatgc     1080

ttcccccacg gcgtttacag actctcctgc ggcaggcggt ggaactacaa agggatcggt     1140

gcctatatca caataccaaa cttgataata atctagattc tgtgtctctg cttatagacc     1200

atgtttgtag taggaggcag ttcccatgtt atacgcagca gatacttacg gagcattgta     1260

atgaagtgtg gttctgtaaa ttctctaatg atggcactaa actagcaaca ggatcaaaag     1320

atacaacagt tatcatatgg caagttgatc cggatacaca cctgctaaaa ctgcttaaaa     1380

cattagaagg acatgcttat ggcgtttctt atattgcatg gagtccagat gacaactatc     1440

ttgttgcttg tggcccagat gactgctctg agctttggct ttggaatgta caaacaggag     1500

aactaaggac aaaaatgagc cagtctcatg aagacagttt gacaagtgtg gcttggaatc     1560

cagatgggaa gcgctttgtg actggaggtc agcgtgggca gttctatcag tgtgacttag     1620

atggtaatct ccttgactcc tgggaagggg taagagtgca atgcctttgg tgcttgagtg     1680

atggaaagac tgttctggca tcagatacac accagcgaat tcggggctat aacttcgagg     1740

accttacaga taggaacata gtacaagaag atcatcctat tatgtctttt actatttcaa     1800

aaaatggccg attagctttg ttaaatgtag caactcaggg agttcattta tgggacttgc     1860

aagacagagt tttagtaaga aagtatcaag gtgttacaca agggttttat acaattcatt     1920

catgttttgg aggccataat gaagacttca tcgctagtgg cagtgaagat cacaaggttt     1980

acatctggca caaacgtagt gaactgccaa ttgcggagct gacagggcac acacgtacag     2040

taaactgtgt gagctggaac ccacagattc catccatgat ggccagcgcc tcagatgatg     2100

gcactgttag aatatgggga ccagcacctt ttatagacca ccagaatatt gaagaggaat     2160

gcagtagcat ggatagttga tggtgaattt ggagcagacg acttctgttt aacttaaaat     2220

tagtcgtatt ttaatggctt gggatttggt gcaaacaaac atgattgata gctggacaga     2280

catgctcgtc atgaaaaaag aaccatttct gaagcccgat tggggccaaa catttacacc     2340

ttgcttcata gtaaccagtt gagatgaagc acgtcgttag aacgttgttg gacaccatgt     2400

tgaattattc ccccatcggt tgtgaagaac tgtgctacat tcaggcttac ccattgaact     2460

cagtatatat atttttttcc ttcctgtctt ttgtctggca ggataccatt cttgttgctc     2520

ttctgtgtaa tgaagtttaa atgcttgttt ggaaaacttt atttaacagt ttagaaggct     2580

tgatagaaag agtgcattag tctgaagagt atacattgga taggaaagaa tttccttctt     2640

ttgtttctcc aaatctttcc gccttattta gcttgagatc tttgcagctt ggttcatgga     2700

ttctagcctt gcccgttgcg cagtatatac tgatccagat gataaaccag tgaactatgt     2760

caaaagcact ctcaatatta catttgacaa aaagttttgt acttttcaca tagcttgttg     2820

ccccgtaaaa gggttaacag cacaattttt taaaaataaa ttaagaagta tttataggat     2880

taaagtgact tcatttgtat acatttggaa tctaaaccag cttaaaaaca gtttcctcaa     2940

tgacttagat acacagtata actgatgctc ttctggaata ccacatgaga catggtcaga     3000

aacagtgctt ggaaggacat tacacaagaa attcagagta atgctttgaa gatttccccc     3060

cttttgtttt attcctgaag gaacatcagt acccgatctt gaagaaattc aagattcaaa     3120

aagaatttta aatacaccaa catgagacat cagtagtcag ttggttttca gtaaagcttg     3180

ttccaagttg ttctcaactt aggaagtaat tttggtgtga tctagcaaaa gagtaggaat     3240

cagcgataca accactttgg aagtttatag tataattgaa attattagaa gaattcagca     3300

ggttacagac atacttaaac tgggattaaa acctcatagt catttttctt aattgccctt     3360

aatattttga catataggga tacataaatt taaagaatat tttttctcag ttttttcaga     3420

tattgccata ctgaacctca ttctaaactg gtgctgtgga tagtctttcc ctctcccctc     3480

ctgttttagt ttaaggaaag gtttccttca tggaaaagca cttttaattt tgagaatttc     3540

acatttaaaa taagccaaaa gcctgatgtt cacattgtgc ttttaaactc cgtaacagct     3600

gaatacaaca taacatagtc tcccttgaaa ttccctccct ttttcagtag aggataaata     3660

gggtgactcc agctgttgga atgagaatgg ggataccccc aaaataagat tctggtgaag     3720

aaaaagtctt gtactaagtt cccctttagg tgtagccaag tctataatat aattatgatc     3780

atgaatagac tccagaatcc acaaagagaa gagggcttgg atgtcaaaaa ttcttccatt     3840

gtggggtagg tggtcgggga tgggagaaag ggaaaagtca gggaagggga gaagaaagaa     3900

aaacacattt ggccttaaaa tagcatgcat tctcccagaa gcccatagta aagaaaatga     3960

cagatcgtgg tcagcagact cttatcaaat tggtatgtaa aagatttctt caagctccat     4020

tttgcagaga ccaccactta gagaatcaaa aaattcctgt tttgatactt ctaagttaaa     4080

atatatgtta cagtttatct ggtacttcat ttttcttaac taaaattact ttttacttta     4140

agcttgaata aaaatcttca ttggtaactg tatgtaatta agtggcaact tctctttacc     4200

tcagtatagt taaaaaccat tcatatttta agtgattcat gtataccctg aagccgttaa     4260

tacaccccag tctctatggt aacatcacta aatgtgggca tagaaactcc acagctgttt     4320

acaaatttgg ttacagtgtg ctacggtgca tttgtaacac tcagatttgt gcccattcag     4380

gggcaatttg gcactcagat tctactctac ttcacctaac cacccctaga tctgagtttt     4440

cagagtgctt ctgaagtaca gtttaaaaac actttttaaa aagtggagta aaagtgaggc     4500

acattttaca agaacataac tcctattaaa acggagtaac aactatgcaa aggtttctat     4560

agcagctagg tgagtttgtt ttccgggtct gtcttaactg gcagcttcct gtacatactg     4620

gtacttattt gctgtaaacg tctgtttcat acatttgcca tgcagtgact gtgctcgaaa     4680

ggtgaaatca atggtaaaga agcctaggat tttatggtat gagaaactga tcgcaggatt     4740

ttctgatcca tagctattaa ttgaaaactt ctgatagtgc tgtaggctct atagtaggct     4800

taagagtgag tcttatacta tgaagccagc cacaagatac taacaaatgt ataaattgaa     4860

aagtaccaat actttttgca catagatcaa aatagagtgg agaatttggg ctccaaaaat     4920

caggttagta ggctcatttc catgtgctta aaaatgtttt tgttgttatg cattgattaa     4980

gggctagagc aaatataaaa ttaaatgtct ttttcctcca aataattggt tattaatggt     5040

aaaatgttgg acttggggat tactgagatt agtatgtggg tagtaaagaa ttggagtggg     5100

agttagtggg gagggatgac aaagcttcag ctttggtttt tgtatttttt tagtcttcat     5160

aacagctaca tttctgttgc tcttattggc cagataaatg tgttatatta aaccaggtaa     5220

gtattttaaa cagagaacat tttatttgca tatatcccta caaattggcc cattttattg     5280

ggtgggggga taaaaaaggg attccctaac tttaaataat cagaatatcc tgcaattgaa     5340

aggagaaaaa aatccaattt tgtcagtatt ttcttagtct gaaaaaaaca gcagtagtaa     5400

tctggtgaat gttattatta ggagtgttct gcctctacag tggcatattc catgacatta     5460

atagaaaacc cttctttccc acccctcccc atcttgacat tttctttttt aggatgttgg     5520

ttcctgcaaa caagaactga ccctatcacc tctgcctcac agtgggtaaa tatatcatac     5580

atctcttgaa agggaaaata tccatgtcag tttctttcac agtagaagaa tggctgcttt     5640

tgaatgggga ggaaagaaga catttttctt aatatccttt ttgtcccatc tctaaaatgt     5700

ataaatattt tgatttggtt ttactttaat ttctcattca taatttcgca actgtccttt     5760

tgggttgccc tccaacacat tacttccatt tcagaaacca tatctgattt aatataaact     5820

gctaacttaa gaagaggtga atttgcattt acacttagac actttctaaa aacagggtga     5880

acttaattga aatttttcag tgttgttaag ctattgttat agtagctgcc ctatagttac     5940

aaaaataaaa actataaaaa cccatcccct atctacttaa tccagatagc ctggatttaa     6000

caaaaccaat agtataaaaa tgtgtgtgtg tgttctgtgt gtgtgtgaga gagagagtac     6060

ttgattcatt aaaaagtcct ggaaacagct gttctaggat cttgtcattt ttactgaaag     6120

tctcgtgcac atgtgaagtg ccctctgagt ttaaggtttg gttaatactg gtatattttt     6180

ataagattga aattgtgtcc ccatctttaa cttaaacatt ttcattatca gggtcaatgt     6240

gctagaactg aattgtaaca tttttaggca cagatggaaa aaaatgttat tggctccttg     6300

aaaatgtgtg tgtgtggcga ggggaataga tccacaaaag catgtatgta cttacaaacc     6360

aagctgtaga gatcaagaaa agaacttaag tgttgatctc aagatttcta aattgtcaag     6420

atttacatgg cattgtggtg gaactagtta acacttagag cttttggtat gtaataacta     6480

tttgctatgg actgattaaa tgtttcaaaa gattgtgttc ttcaattttg gtgggttttg     6540

atttttgttt ttttaactgc ctctcagatt atatttactt agtttaaatt tctttgcttt     6600

attcattaaa gtataaaaac ttcaggtctc tgatatttat tttcacttgt ttactaatta     6660

tttacaaaac accctttgtt gacttttatt ttataaatgt gtaatgtatt aaacgtcttt     6720

aaatttttgt tcaactgaaa ctacattaac tttgatttgc tttactggga ttttttttta     6780

aagacacttt ttccatgtca gtgcgcagca cttaaccagt cgtttgtatt ccctttcttt     6840

caatccaata aacagaatga atacctaaat aa                                   6872


<210> 2759
<211> 1706
<212> DNA
<213> Homo sapiens

<400> 2759
atggagaaaa agaaaatggt aactcagggt aaccaggagc cgacaacaac tcctgacgca       60

atggttcagc cttttactac catcccattt ccaccacctc cgcagaatgg aattcccaca      120

gagtatgggg tgccacacac tcaagactat gccggccaga ccggtgagca taacctgaca      180

ctctacggaa gtacgcaagc ccacggggag cagagcagca actcacccag cacacaaaat      240

ggatctctta cgacagaagg tggagcacag acagacggcc agcagtcaca gacacaaagt      300

agtgaaaatt cagagagtaa atctaccccg aaacggctgc atgtctctaa tattcctttc      360

cgcttccggg accctgacct ccggcagatg tttgggcagt ttggcaaaat cctagatgta      420

gaaataatct ttaatgaacg tggctctaag ggattcgggt tcgtaacttt cgagaatagt      480

gctgatgcag acagggccag ggagaaatta cacggcaccg tggtagaggg ccgtaaaatc      540

gaggtgaata atgctacagc acgtgtaatg accaataaga agatggtcac accatatgca      600

aatggttgga aattaagccc agtagttgga gctgtatatg gtccggagtt atatgcagca      660

tccagctttc aagcagatgt gtccctaggc aatgatgcag cagtgcccct atcaggaaga      720

gggggtatca acacttacat tcctttaatc agtctccctt tagttcctgg cttcccttac      780

cctactgcag ccaccacggc agccgctttc agaggagccc atttgagggg cagagggcgg      840

acagtatatg gtgcagtccg agcggtacct ccaacagcca tccccgccta tccaggggtg      900

gatatgcagc ctacagatat gcacagcctg ctactgcaac cgcagccacc gctgctgcag      960

ccgctgcagc cgcttacagt gacggttatg gcagggtgta cacagccgac ccctaccatg     1020

cccttgcccc tgccgctagc tatggagttg gcgctgtggc gagtttatac cgaggtggct     1080

acagccgatt tgccccctac tgaagtgacg tgagacccct gcaaatggga cagcccccca     1140

gttcatgagg cctggctatt gcaatattta ctagtagagg aactctatag caagatgaag     1200

aggaaaaaca aacaaacaaa caaaaaaaaa cacaaaaaaa gaaagaatac ttttttatac     1260

ctcactatgt tctttgaata tgtatttttc ctttaaattt ctgcctttaa ttcttttgtt     1320

ccaaagattg tgcatttttt tctttttttt tttaaactgt ggtaaaaaaa aaaaaaataa     1380

tgcatttcca tgtctgtatg tccgtgctta gcttattcta tcaatcacgg aagaggcagt     1440

caaggaggaa ggagagacat taggagccga taaatgcatc tgatcagaaa tcagcagaca     1500

gaattaccaa agtgtatctg gtgctgaatg actgggggac aagcagaagt ggaagagatc     1560

tttctgcaac aggatattct tctagtcttc tgagtttctg gtctttgaca ggcaattctg     1620

gttggctgtg gctggaatcc acatgctgat agataggaat ttgtgcttac aaagcaggag     1680

aattaaaaag acgctttcct ctcctc                                          1706


<210> 2760
<211> 460
<212> DNA
<213> Homo sapiens

<400> 2760
acgctgcggg tcctgggccc aggccttggg atgggcggga aggcctggcc gcgccgggct       60

gtgggcactg caggaggccc ctgtgcagat ctcggcccct ttccaaacac tcctgatgcc      120

tcatttgcct ctcgcttctt ttcgaccacc attttggggg ctgaggcact cacggggcct      180

ccccaggttt cactccgttt ctacacagtc ggagccccat ggatctccca tctcccggag      240

gaaccgtgaa gccaaacaga agcgcctgcg agagaagcag gctactctgg aggctgagat      300

agcaggggag agcaagtcac ctgcagaatc cattaaggcc tggaggccta aggagttagt      360

attgtatgaa atccctacga aacccggtga aaagaaagat gtctctgggc ccctgcctcc      420

tgcatacagc ccccgatatg ttgaggctgc ctggtacccg                            460


<210> 2761
<211> 4493
<212> DNA
<213> Homo sapiens

<400> 2761
cccagatagt cacatttaaa ggttgctagt ttgaaatttg caaatgcttc cctgctgtca       60

gagttaggtt tcctacagct gtaagatagc tgctactcaa cctacagcag atgcccgtga      120

cattgtgtgt tcctgggtgt atctcccatc tagcaactcc aaactgtgta tgctgtagtt      180

tgtgttcctg gaactactat cttcaggaga agcttcagtt ataaatagta attggagtga      240

agagatgagt tctgtttagg ggagatccat taactttcaa caagggagga cagggacttt      300

ttcaatagga attgcaataa catggtttgt ttttgaaaat gcaatagact gtggattaaa      360

tagctattgc acacaaagaa gaaaataaag ttataatctc cagcatgaga tctggattta      420

catatgctct gttagctgca agaatttggg caagctattt aatttccata aatttaggta      480

tccttaagat acccactgct tagagttatt gtgagaatta attgaggtaa gaaaactgag      540

gctcaggttg tcatttgctc aaatcacaca gcaaaaccgt gatagaatgc agattcaaac      600

tgggatatta acattccaaa gcctttacag ttattgacta ctattcagca ctgccttcaa      660

tatatgctga tgactgcaca caggagttag aaatgcccac tgtcacttgc ctgccttgag      720

cggtttcttg tttgtataaa taatccaaaa tacttggttg tgttgtaaga agcaccgtgt      780

tttgtgagac atttcaaagg taccacaaat aggaaagatt tcattctaga atgaatagag      840

cacatattta gtatctacgt gctgtttggt taattttagt tatttggtca tgcttttaaa      900

atctattttt atagtatata ttttctttta tagcatatca gaattatctt tagattcaac      960

tcttcatgcc gtcaatcttc attgcaataa catctccaag atcgaagcca ttgatcatat     1020

ttggaattta caacatctag atctgtcatc taatcaaata agtagaattg aaggactaaa     1080

cacactgaca aaactgtgca cattaaattt gtcctgcaat ttgattacaa aagtagaagg     1140

acttgaagaa ctaattaatc tgactagact aaatgtatct tataaccaca tagatgatct     1200

tagtggattg attccccttc atggaattaa gcataaactt agatatattg atctacatag     1260

taatcgtata gatagtatcc atcacttact tcagtgtatg gtaggattgc acttcctgac     1320

caatcttatt ttggagaaag atggagacga taatcctgtc tgtcgactgc cagggtacag     1380

agcagttatt ctccagactt tgccacagct tagaatccta gattgcaaga acatatttgg     1440

tgaaccagta aatttgacag aaataaattc atcacagctg cagtgcctag aaggtctttt     1500

ggataattta gtttcttctg attctcccct aaatataagt gaagatgaga tcattgatag     1560

aatgccagtg ataacagcac ctatcgatga gttagttccc ttggaacagt ttgcaagtac     1620

accaagtgat gctgtgttga cgtcttttat gtctgtgtgt caatcttctg agccagagaa     1680

aaataatcat gaaaacgatt tgcagaatga gataaaactt cagaaattag atgaccaaat     1740

tctacaactt ctaaatgaaa cttctaattc aatagataac gttcttgaga aagaccccag     1800

accaaaaaga gacacagata taacttctga aagtgactat ggaaacagaa aagaatgcaa     1860

tagaaaagtt cctcgaagat caaaaatccc ttatgatgcc aaaaccattc aaactattaa     1920

gcaccacaat aaaaactaca actcttttgt aagttgtaat cgtaaaatga aaccacctta     1980

ccttaaagaa ttatatgtaa gctcatcttt agcaaactgt cctatgttac aagaatcaga     2040

aaagccaaag actgaaataa ttaaagtaga ccaaagtcac tcagaagaca acacttacca     2100

gtcccttgtt gaacagctag accaagagag agagaagaga tggagagctg agcaagccga     2160

aaataaactc atggattata ttgatgagct gcataaacat gcaaatgaaa aagaggatat     2220

tcatagtctg gctctactta ccacagatag gctaaaggaa attattttta gagagagaaa     2280

ttccaaagga caactcgaag ttatggttca caaacttcaa aatgaaatta aaaaactgac     2340

tgttgaacta atgaaagcaa aagatcaaca agaggatcac cttaaacact taagaaccct     2400

cgaaaaaaca ttagaaaaaa tggagagaca aaaaaggcag cagcaggcag cacagataag     2460

actgatccaa gaggtggaac tcaaagcttc agctgccgat agagaaatat acttacttag     2520

aacttccctt catcgagaaa gagaacaagc gcaacaactt catcaacttc ttgcattgaa     2580

agaacaggaa cacaggaagg aacttgaaac aagggagttt tttactgatg ctgacttcca     2640

ggatgcctta gctaaagaaa tagccaaaga agagaaaaag catgagcaaa tgataaaaga     2700

ataccaagag aaaattgacg tgttaagcca gcagtatatg gatttagaaa atgaattccg     2760

tattgcttta actgttgaag ccagaagatt tcaagatgtt aaagatggtt ttgaaaatgt     2820

tgcaactgag ttagcaaaga gcaaacatgc tcttatttgg gctcaacgaa aagaaaatga     2880

gtcttcctct ttaattaaag atctgacctg tatggtaaag gaacaaaaaa caaaactggc     2940

agaagtttct aaattgaaac aagaaacagc agcaaattta cagaatcaaa tcaacaccct     3000

tgaaatttta attgaagatg acaagcagaa gagtattcaa atagaacttc tcaagcacga     3060

aaaagtccag cttatttctg agctagcagc caaggaatca ctaatatttg gtttaaggac     3120

agaaagaaaa gtatggggac atgagctggc acaacaagga tcttctctag cccaaaatcg     3180

tggaaaattg gaggctcaaa ttgagagttt atctagagag aatgaatgtc tgcgaaagac     3240

aaatgaaagt gatagtgatg cattaagaat aaagtgcaaa atcatagacg accaaactga     3300

aactattaga aaattaaaag attgtttaca agaaaaagat gaacacatca aaagattaca     3360

agaaaagatc acagaaatag aaaaatgcac tcaagaacaa cttgatgaaa aatcttcaca     3420

actggatgag gtacttgaga agttggaaag gcacaatgaa agaaaagaaa aactaaaaca     3480

acagttgaaa ggaaaggaag tagaacttga agaaatcaga aaagcttaca gtacactgaa     3540

tcggaagtgg catgataaag gagaacttct atgtcatctt gaaacacaag taaaagaagt     3600

gaaagaaaaa tttgaaaaca aggaaaagaa acttaaagcg gaaagagaca aaagtattga     3660

actacaaaag aatgcaatgg aaaaacttca tagtatggat gatgccttta aaagacaagt     3720

tgatgcaatt gttgaagctc atcaagctga aatagcacag ctggccaatg aaaagcagaa     3780

gtgtattgat tctgcaaatt taaaggtcca tcaaattgaa aaagaaatgc gtgaactttt     3840

ggaagaaaca tgcaagaaca aaaaaacaat ggaagcaaaa attaagcaac ttgcttttgc     3900

tttaaatgaa attcagcaag atatgtgatg gttctgagaa tgaatttaat tgaaatagac     3960

cagcagacct attgtaaaaa tgattaaata ttgtaatagt agtaactgct atgactttga     4020

aatgtctctt tctatacatt tcattatgaa tatattttta aagacttttg atcaagtatt     4080

tattaattgt ataggttttt tataataaat tgttgacaat tttgtctatt agaaaaaact     4140

atcataacta gacttacaat atttttcttg tttctgtact atacattgtt tggtaattac     4200

acatttgcct acaaatttgt gaatgaaaag attagtattt tcaccatatg aggtaaaaca     4260

ttttaatcat tgttatctta ttgtgatgat gaagaactaa ttatatttgt tatttaattg     4320

atgtagctca attcttttaa agtacttatg tagccaaaaa gcatttgaaa tctgtatgat     4380

aaaagatgtg gcattcttaa gaaagtatat gtagccatct ccacatcact cattatgacc     4440

ccttctttta taatgcttat atcttttcat taaagattac atttaaggtt tta            4493


<210> 2762
<211> 6676
<212> DNA
<213> Homo sapiens

<400> 2762
gtgggctcgg cccgggctgc cacgagcgtg cgggcctcgc cgggcatgtc ctaggcggcg       60

gccccgccca gcgctcggcc gggcgggcgg gcgggcgcga gggcagggac cgagccgggc      120

cgagctgggg aacaagccgg ggaccaagcc ggggaccaag ccggggacta aggcgagccg      180

gagaccgagc ccgaacagca gggccagacg ggcccagcca gcaccaagat gagtgccacg      240

tcctggttcc tggtgagcag cagcggcgcc cgccaccggc tccctcggga gctcatcttc      300

gtggggcgtg aggagtgtga gctcatgcta cagtcccgca gcgtggacaa gcagcatgcc      360

gtcatcaact acgaccagga cagggacgag cactgggtga aggacctggg cagcctcaat      420

gggacgtttg tgaatgacat gcgcatcccg gaccagaagt acgtcacgct gaagctcaac      480

gatgtcatcc gcttcggcta cgattccaac atgtatgtgc tggagcgtgt gcagcaccga      540

gtcccggagg aggcactcaa gcatgaaaag tacaccagcc agctgcaggt gagcgtgaag      600

ggtttggcgc ccaagaggag cgaggcactg ccggaacaca caccatactg cgaggcctcg      660

aaccccaggc cggagaaggg ggaccggaga ccaggaacag aggcagcctc ttaccgcaca      720

cccctgtatg ggcagccctc ctggtggggt gaggacgatg gtagcacgct gcctgacgcc      780

cagcgccagg gagagcccta cccagagcgc cccaagggac cagtgcagca ggacggggag      840

ctccacggct tccgcgcccc tgctgagcct cagggctgct cgttccggcg ggagcccagc      900

tacttcgaga tccccacgaa ggagaccccg cagccgtcgc agccccccga ggtgccggca      960

cacgagatgc ccacgaagga tgcagaggca ggtgggggcg gagcggcccc tgtggtgcag     1020

agccacgcct ccttcaccat cgagtttgat gactgcagcc ctggcaagat gaagatcaag     1080

gaccatatca ccaagttttc cctgcgccag cggcggcccc cgggcaagga ggccacacct     1140

ggcgagatgg tgtcggctga gaccaaggtg gccgactggc tggtgcagaa tgacccgagc     1200

ctgctgcacc gggttggccc tggggatgac cgccacagca ccaagagcga cctgcctgtc     1260

cacacccgca ccctgaaggg ccacaagcac gaggacggca cgcagagtga ctcagaggac     1320

cccctggcca aggcggcctc ggccgctggg gtgcccttgg aggccagcgg ggagcaggtg     1380

cggctgcaga ggcagatcaa gcgggacccc caggagctac tacataacca gcaggccttt     1440

gtcatcgagt tcttcgacga ggacacaccc cgaaagaagc gctcccagtc cttcacgcac     1500

agcccgtccg gggaccccaa ggccgacaag cgccgtggcc caacgccggc cgatagggac     1560

cgccccagtg tcccagcccc agtccaggca gggggccgca gctcggggcc acagagggcc     1620

ggctcgctca agcgggagaa gacagaggaa cggctgggca gcccctcgcc cgcctcccga     1680

acccctgccc gccccttcgg aagcgtgggg cgccgctccc gcctggccca ggacttcatg     1740

gcccagtgtc tgcgggagag ctccccggcc gcccggccca gccccgagaa ggttcctccg     1800

gtgctgcccg ctcccctgac accccatggg accagccccg tgggcccccc gaccccaccg     1860

cccgccccca cggaccccca gctgaccaag gcacggaaac aggaggagga cgacagcctc     1920

agtgacgcag ggacatacac catcgagacc gaggcgcagg acacggaggt ggaggaggcc     1980

cggaagatga tcgaccaggt ctttggggtg ttggagtccc ctgaactctc cagggcatct     2040

tcggccacct ttcgcccagt catcagaggg gacagagatg agtctgatga cgggggcgtg     2100

gcccagcgga tggcgctact gcaggagttt gcctcccggc cactgggtgc ggccccccag     2160

gcggagcacc agggcctccc ggtgccgggc tcccctgggg gtcagaagtg ggtgtcccgc     2220

tgggccagcc tggctgacag ctactcagac ccgggcctca cagaggatgg cctgggacgt     2280

agaggcgggg agccggaggg gtccctgcct gtgcgcatgc ggcgacggct ccctcagctg     2340

cccagtgaga gggctgacag ccctgcgggc ccagagagca gcaggaggag tgggcctggg     2400

ccaccggagc tggacagtga gcagcccagc cgcctcttcg gccaggagga gttggatcct     2460

gacagcctca gcgatgccag tgggtcggac gggggccgag gccccgagcc aggggtggag     2520

ccacaggaca gcagacgcag gagcccccag gaggggccca cgtggagcag gggtcggcgc     2580

tcaccaaggg cccccgggga gccaactccc gcctctttct tcattgggga ccagaatggg     2640

gacgctgtgt tatctaggaa accgcttgcg gctccagggg atggggaggg cctagggcag     2700

acagcccagc ccagcccccc agcacgggat ggcgtctatg tcagtgccaa tgggagaatg     2760

gtcatccagc tacggcctgg acggtcccca gaacccgacg gccctgcccc agcctttctc     2820

cggcaagaga gcttcactaa ggagccagcc agtggtcccc cagcgcccgg caagcccccc     2880

cacatctcca gccacccgct tctacaggac ctggccgcta cccgggccgc acgcatggac     2940

ttccactccc aggacaccca cctgatcttg aaggagacgg agacggccct ggcggccctg     3000

gaggcccgac tcctctctaa ttctgtggat gccgagtgtg aggggggcag caccccgagg     3060

ccgccggagg acgccctgtc tggggactcg gacgtggaca cagccagcac cgtcagcctg     3120

cgtagtggca agagcgggcc cagccccaca accccccagc ctctgcgggc acagaaggag     3180

atgtcgccat ccccgccagc tgcacaggac ccgggaggca ccgccctggt cagtgcccgt     3240

gagcagtcct cagagaggca gcatcaccca cttggcccga cggacatggg ccgtggagag     3300

ccggtacggc gctcagccat aaggcgtggc cacaggcccc gagggtccct ggattggccc     3360

agtgaggagc gtggccctgt cctcgcccac ctacccagct cagatgtgat ggcctccaac     3420

cacgaaaccc ctgaggccac cggggcagga cggctaggtt ctcgccggaa accagcggcc     3480

ccaccgccat ccccagctgc ccgggaggag cagagccgta gctcagccag ctcccagaag     3540

gggccgcagg ccttgacccg ctccaacagc ctgtccaccc ctcgccccac acgggcctcc     3600

cggctgaggc gggcccggct gggggacgct tcagacactg aggctgcgga tggtgagcgg     3660

gggtccctgg gcaaccctga gcccgtgggc cggccagctg ctgagcaggc caagaagctg     3720

tcacgcctgg acatcctggc catgccccgg aagcgggccg gctccttcac agggactagt     3780

gaccccgagg cagcccctgc ccgcaccagc ttctctggcc gcagtgtgga gttgtgctgt     3840

gccagccgca agcccaccat ggccgaagca cgggctgtct ccaggaaggc tgccaacaca     3900

gccaccacca cgggtccccg ccagcccttc agcagggccc gctcaggcag tgcccgatac     3960

acctccacca ctcagacccc gagggctggc agctccagcc gggctcgttc ccgggccccc     4020

ggcccccggg acacggacga cgatgaggag gagcctgacc cttatggttt catcgtgcag     4080

acggcagaga ttgcggagat tgccaggctg agccagacgc tggtgaagga cgtggccatc     4140

ctagcccagg agatccacga tgtggctggg gacggtgaca cactgggctc ctcggagcct     4200

gcccacagcg cctccctcag caacatgccc agcacccccg cctcgaccat ctctgcccgg     4260

gaggagctgg tgcagcgcat ccccgaggcc agcctcaact tccagaaggt gccgcccggc     4320

tcgctgaact ctcgggactt tgaccagaac atgaacgaca gctgtgagga cgccctggcc     4380

aacaagacgc ggcctcggaa ccgagaggag gtgatcttcg ataacctgat gctgaacccg     4440

gtgtcccagc tgtcgcaggc catccgtgag aacacagagc accttgccga gaagatgaag     4500

atcctctttc agaacacagg gagagcttgg gaggacctgg aagccaggat caacgccgag     4560

aacgaggtgc ccatcctgaa gacatctaac aaggaaatca gctccatcct gaaggaactg     4620

aggcgggtgc agaaacagct ggaagttatc aatgccatcg tggaccccag tgggagcctg     4680

gacctgctca caggaaacag gagcttggcc agctctgcac agccggggct ggggaagggc     4740

cgcgtggctg cccagagccc accctcaccc gcctcagccg aggccctgct gccagccctg     4800

cccctgagga atttcccaca gcgggccagc tgtgggcctc ccagcctccc ggaccccacc     4860

ttcctccctg atgccgagag gttcctgatc taggccccag acctggccag gccagcctcc     4920

ctgtgcgtgt gcgtctctgc cttccgtccg ccgcacaccc gcctgcctgg ccgcaggtgg     4980

ttctccctga agacccccac atgtgccata tccctgtggg cgggtgcctc ccacgccctt     5040

gccccctcgt cagctcccag ccagcaccct actcaccctg tccagcccca tggccacccc     5100

cacccctgcc tcgcccccta caggcctctg ggcccagctc ctggccaggc tgctgccaag     5160

gtcaagccct caagggcatt accccgcctc ctcttcatca ctgttatttt tgtctttagc     5220

tttaaaggaa agagttgttg gtgccattgc aggtgccccc tccaggcctg actggctccg     5280

ccaggcacta acctgccata accctttgtg ctggcctgcg gccaggcaga ggaagagagg     5340

tcgactgtgg ggtcatttgg tgccaaacat ggaggtgggc aggctcacct gttcctggga     5400

ctgtctgaga tggcagggca cttgccctgg tggctcccac ctgaccccag gccttttata     5460

ggcaggagcc ccactgcttc cagcctctgg tgccaacaca gttgccaaac ccattgagct     5520

tggggctgcc ctgtggaggc ctcctgggta tggaccaggg gcttgttgag agctgagcca     5580

tgcacacagg tgcagacacc ccccaactcc catgcacacg gctagtccag gcgcctccac     5640

gctgcaccgt gaggactgca gggcatgtcc ccgtgagggg ctatgggcct ctgtaggtgg     5700

gcttccaagg tcctgggtgc agccgggtgc atggcagccc ttctggcggg ggtgagcgca     5760

cgaccaaagt cactggaagc cgggtttccg gaagctcgca gcttggcctg caccacacgc     5820

cctccccttt tggcttcacg ccatcaggcc tcaagtgggc atgggggcag ggacgggccc     5880

aggaactgtt gttttctcag gattctttca gctgggaaca tggcaggtga gcagagcttg     5940

gtgcctctgc cgtggcccct gctggggcag cccgtgttgc cggagcctct aagccaaaga     6000

gcccgttggc cgtggttggt gggggtggac gtgggggtgt cccacctgga ccagactggc     6060

gtgggtgagc tccacaccct gcctggcaat ggtatgagag tcggacctgg acagggccag     6120

ctgctggggg agcggcactg gggactggag gctggaagcg ggtggtgtgt gtcccctgtt     6180

tacttttagc tgagctgggg ttgggtgtac gggttctgtt cctctgagcc tgcggcccac     6240

ctgatgttta cgtgtgtgtg tgaggggggg cgggggtggc aggtgtcccc ccctggtccc     6300

cgccccaaga gcctgctgtc tgtatggagg aggtgctagc ccggtccacc gggctgctgc     6360

ccacccctgc atgccccagt tgcccacccc gcctgcccct ggacatgaag tggtcacgct     6420

tcatccacgg ctccttccca cccctcggca gtggctgtgc aatgttttaa gttcacaagt     6480

tcctgctcct ccccacactg agctcctttg ttcctccccc tccagccttt gcctgggaac     6540

tggtccttgt ttgccgggct tctcggaggg ttcactgtac attcgttctc aggtggtctt     6600

gtggctgtct ttcggaaaat ggttatttta tatgatttgt catggaattt gttctaataa     6660

atcattcttc tatcac                                                     6676


<210> 2763
<211> 3229
<212> DNA
<213> Homo sapiens

<400> 2763
attatcttac ttttggttcc ctcagaagaa acagatgaaa atgatttgat cctggaagta       60

actgcaggag ttggaggtgg ccttagacat gcatctgcca gcattggggg ttcagaagcc      120

tataggcaca tgaaatttga aggaggtgtt cacagagtac aaagagtgcc aaagacagaa      180

aagcaaggcc gcgtccatac tagcaccatg actgtagcaa tattacccca gcctactgag      240

attaatctgg tgattaatcc gaaagatttg agaattgaca ctaagcgagc cagtggagct      300

ggggggcagc atgtaaatac cacggacagt gctgtccgga tagttcatct tccaacaggt      360

gttgtttctg aatgtcaaca agagagatct cagctgaaaa ataaagagct ggctatgaca      420

aagttacgtg caaaactgta cagcatgcat ctagaagaag aaataaataa aagacagaat      480

gctagaaaaa ttcagattgg aagtaaagga agatcagaga aaataagaac atataatttt      540

ccacagaacc gggtcacaga tcacagaata aacaagacgc tgcatgatct tgaaactttt      600

atgcaaggag attatctact ggatgaactt gtacagtcat tgaaggaata cgccgattat      660

gaatctttag tagaaattat ttcccaaaaa gtttaagttg atttgttatt tatagacttt      720

cgtatcttag aaaaattcta cagtacatcc acatagggtg aaagtaccct tactctcttg      780

aaaaacgttg agttaacaca gttggaggta atatgcatat tctgaagtca tagataattt      840

acacagatct ctctcaatgc attagcaaaa atcatacaat atacagatgg tcctcgattt      900

acattgtggt taattcccaa taaacccatc ataagttaaa aatgcatata acgttagcaa      960

cacagcagtc tcctaattaa tgacagcttg acttaacaat tttccaactt taccatggtg     1020

tgaaagaggt atgattccta agccctaagg agctcctcag cttgaaatgg ggctgcatcc     1080

ctataaaccc atcataaagt caaaaaatcc taaaacataa gttggtgacc atctgtaatc     1140

atgatgtggt ggtaaatctt ggacgctacc ttacaataac tagacaaagg aaaatcatcc     1200

tttgtcctgt tctgtgtaaa tatttaatga atgatcaaaa cttcagttta aatattatga     1260

aaaactttaa acataaagta gtagaaataa gacagtaaat actgtatcct aatatccagt     1320

caggatacag aaaccatacc attaacttga acagggataa ttttaatata aaaactgtta     1380

actgataatg gtattaactt ttaagaggga tgaaagagag ctatgatgtc ctaggactga     1440

gagtacccca ggaaagaata cccttgaaag ggtctcccct tccccatggt gaagtcaggc     1500

ctaatggaga gagtggctac agcctactca gtgattggga aattccctgt cttgccctgg     1560

gccagagctg gtgtaccgct ggtggatcag gtcttacaag caaagaacct cacactccca     1620

actggtaagc cagaagcctc ttgctagggt gtgagcaaaa cttggacagg aactctcagt     1680

agatgtttgt gtttgtcaag attctccaga caaacttcct taaaaggatt ggcttgtgtt     1740

gttattatta agtctaacaa gtccaaaagc tggagtgtga ggcaggaggc tggaaaccca     1800

ggaaagctga tggtgcaagg tccagtccaa aggtatctgt tggaggattc tcttgttctg     1860

ggaagaggac ggtctttttt tctcttcaga ccttcacctg actggatcaa gcccactaac     1920

atcgaggagg acagtctgca ttactcagag ttcactgatt gatttaaatg tcaatctcat     1980

ataaaacacc ctcacagaaa cacctagaat aatgtttgac cttataattg gaaaatcaga     2040

gcaaaagtta aatctcaaaa aaaaaaaaaa aaaaagtatg acccagtagc taggcacctg     2100

tggccccgcc aagttgacac ataaaattaa ctgtcacagt atcatcttag aagtgaaaga     2160

agccccttta tcctgcagtg cccctctacc accacctact gacaaagaac atggtgctat     2220

ctggcatggg agaaatgttc agtttgctat ggcttgtatg tgtcccctca aattcaagtg     2280

ttgccaatgt gacagcatca agaggtgggg tctttaagag atcactaggc catgagggat     2340

tctcttagga ctgggatgaa ggcccataat aaaagaggtt tcggggagca tcctgctagc     2400

ttgccttctg tatgtgagaa cacagcaaga aagccctagt caacaagtgc cagctccttg     2460

atcttagact tcccatcctc cagaactgtg agaaatacat ttctgttcct tacaaattac     2520

ccagtctcct gtattctgtt atagcagcac aaaatgaaga taccatacct gaacacctga     2580

acattcttca caaggtagta aatgcactgc tttattctgg tctcagtatt gtgtgcttaa     2640

taaggaaatg agaaagggtg gatcagggca taggatgaac aagttactgc tagacctctc     2700

acaatgccac taatggataa gattgtattt tcatcattct tgtctcttcg gaagctaaca     2760

ccatgctata ataggcacta aatagatgtc taaaaacacc ttaagtattt gtctagaaat     2820

ctggtgcatt gttcagaaag aaccaaaatt caaaataatt tcaaagggcc taaagcacta     2880

gttaatcaaa attcattagt ttttaatggt actaccactc tcaaatttaa aatgtcatct     2940

tacgttcctc ttcctcgcat tggatttatt gctaaaacct ggtaaacact tttaatcctt     3000

ttcaattcca ttaccactgc tcttgtccag aattacttcg cagactaata gtcacctgac     3060

ttctcccctg catccgattt gctgtctaat tctggttaca aataagtaac tgccaaacta     3120

atctttctaa aaagcaagac tgatctcgtc actcctttgc tcaacaatgt aaaagctccc     3180

attgtctccc aaataaaacc agctttccac tgtgtataca atacatcca                 3229


<210> 2764
<211> 1476
<212> DNA
<213> Homo sapiens

<400> 2764
gaaagagcag aagaggaggt ggggtggagg gagcagagcc agggattagg ggactactga       60

ggctctggag atgagaccgc caggagtcct tccccaccat gagccccctc cactcctgca      120

gctggaggag tttttcccag tctcagtgct gccctggggc gagagagact gaacaagctg      180

tttgggtggg aagagaatgg aggaagttga cagggatggg cggggcccgt gggggggctg      240

accaggaacc cagcttcctg ctcagtaccc aggcatccag cccccagctc acccccaccc      300

cttccagccc ccactcccct caggaaccca aggttccagc cctcctccca aatcccagcc      360

acccctcccc caccagtttc tcccctctag gggatggagg ctgagagacc ccaggaagaa      420

gaggatggtg agcagggccc ccctcaggat gaggaaggct ggccccctcc aaactccacc      480

actcggcctt ggcgatctgc tcctccatcc cctcctcctc cagggacccg ccacacagcc      540

ctgggacccc gctcggcctc cctgctctcc ctgcagactg aactccttct ggacctggtg      600

gctgaagccc agtcccgccg cctggaggag cagagggcca ccttctacac cccccaaaac      660

ccctcaagcc tagcccctgc cccactccgt cctctcgagg acagagaaca gctttacagc      720

actatcctca gtcaccagtg ccagcggatg gaagcccagc ggtcagagcc tcccctccct      780

ccaggggggc aagagctcct ggagttgctg ctgagagttc agggtggggg tcgaatggag      840

gagcaaaggt cccggccccc cacacacacc tgctgagact tgagccccaa ccagcccttc      900

cttgccactg gtctcaaagc tgggcagccc attgcatgcc ctcaactctt gcttggcagg      960

ggtaccagag actgaaagac acggcacaaa tctcaatatt catctcccac atcaccttcc     1020

ctgggaactg gacagggtga aagtcctcaa actctgggaa caggcgagat ggaacaggga     1080

tttaactccc cgcccacagg tccatgggag cttgaggcag taagggggat cccaggcacc     1140

catctcaagg agtggctggg agtcttttcc ctaacttgtg gggacaccac cagttgtcaa     1200

gctactaggc agtagggtct gagggctcag gcctccacct gagaggttat aacctgagag     1260

acagctctac ccttcctccc agtaagaagg gaaggtgggt gggcacctga gagattaaga     1320

ctattctccc agtcccacta ccagcacccc cgatccctga gactgagggg tttacgggct     1380

gtgaatggac cttcagccct gcccaccctc cctccccact gctgctgagt ctgtctgatg     1440

ttttggttgt gtgaataaat ataattcccc tctgga                               1476


<210> 2765
<211> 999
<212> DNA
<213> Homo sapiens

<400> 2765
acagaagtta aacttctttc cagggaagaa gggcggggat gtcagggctg gagagtgccc       60

gtgtccttct gtgtgcattg ggctccttcc tccttaattc tctgctttcc acttttaggc      120

tgaactccag tgcacccagt tagacttgga gcggaaactc aagttgaatg aaaatgccat      180

ctccaggctc caggctaacc aaaagtctgt tctggtgtcg gtgtcagagg tcaaagcagt      240

ggctgaaatg cagtttgggg aactccttgc tgctgtgagg aaggcccagg ccaatgtgat      300

gctcttctta gaggagaagg agcaagctgc gctgagccag gccaacggta tcaaggccca      360

cctggagtac aggagtgccg agatggagaa gagtaagcag gagctggaga cgatggcggc      420

catcagcaac actgtccagt tcttggagat gtgcatgaca tcacgttcga cccggacaca      480

gcacacaagt atctccggct gcaggaggag aaccgcaagg tcaccaacac cacgccctgg      540

gagcatccct acccggacct ccccagcagg ttcctgcact ggcggcaggt gctgtcccag      600

cagagtctgt acctgcacag gtactatttt gaggtggaga tcttcggggc aggcacctat      660

gttggcctga cctgcaaagg catcgaccag aaaggggagg agcgcagcag ttgcatttcc      720

ggaaacaact tctcctggag cctccaatgg aacgggaagg agttcacggc ctggtacagt      780

gacatggaga ccccactcaa agctggccct ttctggaggc tcggggtcta tattgacttc      840

ccaggaggga tcctttcctt ctatggcgta gagtatgatt ccatgactct ggttcacaag      900

tttgcctgca agttttcaga accagtctat gctgccttct ggctttccaa gaaggaaaac      960

gccatccgga ttgtagatct gggagaggaa cccgagaag                             999


<210> 2766
<211> 1184
<212> DNA
<213> Homo sapiens

<400> 2766
aaaagactta ttgacagtgc caaagctcgg tactggacac aacgagggac ctgggtctac       60

gataacgcgc ttttgctcct cctgaagtgt ctttggtcca acgttgttcc agagtgtacc      120

atggcttcca gtaacactgt gttgatgcgg ttggtagcct ccgcatattc tattgctcaa      180

aaggcaggaa tgatagtcag acgtgttatt gctgaaggag acctgggtat tgtggagaag      240

acctgtgcaa cagacctgca gaccaaagct gaccgattgg cacagatgag catatgttct      300

tcattggccc ggaaattccc caaactcaca attatagggg aagagctcgt ggtctgggtt      360

gatcctctgg atggaaccaa ggaatatacc gaaggtcttc ttgacaatgt aacagttctt      420

attggaattg cttatgaagg aaaagccata gcaggagtta ttaaccagcc atattacaac      480

tatgaggcag gaccagatgc tgtgttgggg aggacaatct ggggagtttt aggtttaggc      540

gcctttgggt ttcagctgaa agaagtccct gctgggaaac acattatcac aactactcga      600

tcccatagca acaagttggt tactgactgt gttgctgcta tgaaccccga tgctgtgctg      660

cgagtaggag gagcaggaaa taagattatt cagctgattg aaggcaaagc ctctgcttat      720

gtatttgcaa gtcctggttg taagaagtgg gatacttgtg ctccagaagt tattttacat      780

gctgtgggag gcaagttaac cgatatccat gggaatgttc ttcagtacca caaggatgtg      840

aagcatatga actctgcagg agtcctggcc acactgagga attatgacta ctatgcaagc      900

cgagttccag aatctattaa aaatgcactt gttccttaaa ggaaagtttc atttggccgg      960

gcgcggtggc tcatgcctgt aatcccagca ctttgggagg ccgaggcagg tggatcactt     1020

gagctcagga gtttgagacc agcctgggca atatcgtgag accccatctc tacaaaaata     1080

caaattaact gggcatcctg tcatgcgcct gtcatcccag ctacttgaga ggctgaagca     1140

gaagaatctc ttgagcccgg aaggcagagg ttgcagtgag ctga                      1184


<210> 2767
<211> 885
<212> DNA
<213> Homo sapiens

<400> 2767
tttgatatga cgattagagc ataacccgag tgacacgttg aattcgccat aatcaaggaa       60

accttttccg ggtggggatc tctgaaatta ctcagataac agtgctgtgc caaaaacctg      120

tggattttct ctacaaaaat tatcatgact gttatctttt tgatggaaaa gatgaagttc      180

agcgaagaac aaatctacaa cttggccaga agactgtaga ctttgccttc aaagagtgag      240

caaccctaat taacctgatt ttttgctgat aatcactctc aatggaatca aatcacaaat      300

ccggggatgg attgagcggc actcagaagg aagcagccct ccgcgcactg gtccagcgca      360

caggatatag cttggtccag gaaaatggac aaagaaaata tggtggccct ccacctggtt      420

gggatgctgc accccctgaa aggggctgtg aaatttttat tggaaaactt ccccgagacc      480

tttttgagga tgagcttata ccattatgtg aaaaaatcgg taaaatttat gaaatgagaa      540

tgatgatgga ttttaatggc aacaatagag gatatgcatt tgtaacattt tcaaataaag      600

tggaagccaa gaatgcaatc aagcaactta ataattatga aattagaaat gggcgcctct      660

taggggtttg tgccagtgtg gacaactgcc gattatttgt tgggggcatc ccaaaaacca      720

aaaagagaga agaaatctta tcggagatga aaaaggttac tgaaggtgtt gtcgatgtca      780

tcgtctaccc aagcgctgca gataaaacca aaaaccgagg ctttgccttc gtggagtatg      840

agagtcatcg agcagctgcc atggcgagga ggaaactgct accag                      885


<210> 2768
<211> 2146
<212> DNA
<213> Homo sapiens

<400> 2768
gtaacgttcg ggctccgtct caggggctga agtttgtgag gtgtagtatt gagtcctgtt       60

tgagctattg ttctcttttt cctgaaaaat ggcactgtca aagagggagc tggatgagct      120

gaaaccatgg atagagaaga cagtgaagag ggtcctgggt ttctcagagc ctacggtggt      180

cacagcagca ttgaactgtg tggggaaggg catggacaag aagaaggcag ccgatcatct      240

gaaacctttt cttgatgatt ctactctccg atttgtggac aaactgtttg aggctgtgga      300

ggaaggccga agctctaggc attccaagtc tagcagtgac aggagcagaa aacgagagct      360

aaagatcaaa cagatgatgg aggcagcaac acgacaaatc gaggagagga aaaaacagct      420

gagcttcatt agccccccta cacctcagcc aaagactcct tcttcctccc aaccagaacg      480

acttcctatt ggcaacacta ttcagccctc ccaggctgcc actttcatga atgatgccat      540

tgagaaggca aggaaagcag ctgaactgca agctcgaatc caagcccagc tggcactgaa      600

gccaggactc atcggcaatg ccaacatggt gggcctggct aatctccatg ccatgggcat      660

tgctcccccg aaggtggagt taaaagacca aacgaaacct acaccactga tcctggatga      720

gcaagggcgc actgtagatg caacaggcaa ggagattgag ctgacacacc gcatgcctac      780

tctgaaagcc aatattcgtg ctgtgaagag ggaacaattc aagcaacaac taaaggaaaa      840

gccatcagaa gacatggaat ccaatacctt ttttgacccc cgagtctcca ttgccccttc      900

ccagcgccag agacgcactt ttaaattcca tgacaagggc aaatttgaga agattgctca      960

gcgattacgg acaaaggctc aactggagaa gctacaggca gagatttcac aagcagctcg     1020

aaaaacaggc atccatactt cgactaggct tgccctcatt gctcctaaga aggagctaaa     1080

ggaaggagat attcctgaaa ttgagtggtg ggactcttac ataatcccca atggctttga     1140

tcttacagag gaaaatccca agagagaaga ttattttgga atcacaaatc ttgttgaaca     1200

tccagcccag ctcaatcctc cagttgacaa tgacacacca gttactctgg gagtatatct     1260

taccaagaag gaacagaaaa aacttcggag acaaacaagg agggaagcac agaaggaact     1320

acaagaaaaa gtcaggctgg gcctgatgcc tcctccagaa cccaaagtga gaatttctaa     1380

tttgatgcga gtattaggaa cagaagctgt tcaagacccc acgaaggtag aagcccacgt     1440

cagagctcag atggcaaaaa gacagaaagc gcatgaagag gccaacgctg cccgaaaact     1500

cacagcagaa cagagaaagg tcaagaaaat taaaaagctt aaagaagaca tttcacaggg     1560

ggtacacata tctgtatata gagttcgaaa tttgagcaac ccagccaaga agttcaagat     1620

tgaagccaat gctgggcaac tgtacctgac aggggtggtg gtactgcaca aggatgtcaa     1680

cgtggtagta gtggaagggg gccccaaggc ccagaagaaa tttaagcgtc ttatgctgca     1740

tcggataaag tgggatgaac agacatctaa cacaaaggga gatgatgatg aggagtctga     1800

tgaggaagct gtgaagaaaa ccaacaaatg tgtactagtc tgggagggta cagccaaaga     1860

ccggagcttt ggagagatga agtttaaaca gtgtcctaca gagaacatgg ctcgtgagca     1920

tttcaaaaag catggggctg aacactactg ggaccttgcg ctgagtgaat ctgtgttaga     1980

gtccactgat tgagactact gcaagccctt gcctctcctc ccttgccttt gtctcttcag     2040

tcctctcact tattctattt cccaaccccc tcccacttgt ttgtgtgatc tcagaactgt     2100

gccaagcaga cactgggaca aagggagaat atcttgctcc cctcct                    2146


<210> 2769
<211> 4073
<212> DNA
<213> Homo sapiens

<400> 2769
gccagctgct gcgcatgcgc cggccggggc cccgccccca tgcgccgcgc ggctccaggg       60

ccacgttcca gggtcgggtt tggtggattc ctcagtccct gccgccgcgg ggcgccctgg      120

gatagcggcg gggcctcctg gtgagcgcgc gccggggcgg cctccgggaa gtgggagacg      180

ctgcgggtcc tgggcccagg ccttgggatg ggcgggaagg cttggccgcg ccgggctgtg      240

ggcactgcag gaggcccctg tgcaggtgga gatcgccgcg gccctggcgg gactccttgc      300

tggctcttgg gcgcgctgat gcccatcatc tccctgagtt tctgagccct atctctcatg      360

tgtcagtggt caccgccgaa tccagacact ccggccctgt tccggaagag ccctgatatc      420

cgtggctcca tggcgctgtc tgtcgatacc atgcactcta gctctcaagg aggaaaggtt      480

ttgtggaagg gaatagagac ttggaataac agacctgtgc taattagaga caggaaagat      540

ggaacaaggg gagtgaccct tctccacccc catatcctaa tgtgctctct ctctatccag      600

aacagatctc ggcccctttc caaacactcc tgatgcctca tttgcctctc gcctcttttc      660

gaccaccatt ttgggggctg aggcactcac ggggcctccc caggtttcac tccgtttcta      720

cacagtcgga gccccatgga tctcccatct cccggaggaa ccgtgaagcc aaacagaagc      780

gcctgcgaga gaagcaggcg actctggagg ctgagatagc aggggagagc aagtcacctg      840

cagaatccat taaggcctgg aggcctaagg agttagtatt gtatgaaatc cctacgaaac      900

ccggtgaaaa gaaagatgtc tctgggcccc tgcctcctgc atacagcccc cgatatgttg      960

aggctgcctg gtacccgtgg tgggtacgag agggcttctt caaaccagaa tatcaggccc     1020

ggctgcccca agctacaggg gagacctttt ccatgtgtat cccacctccc aatgtcactg     1080

gctccctgca cattggccac gcactcacgg tggccataca ggatgccctc gtgcgctggc     1140

accggatgcg tggggatcaa gtgctgtggg tccctggttc agatcatgca ggaattgcta     1200

cacaagctgt ggtggagaaa caactgtgga aggaacgggg agtgaggaga catgagctga     1260

gccgggaggc cttccttagg gaggtgtggc agtggaagga ggcgaaaggt ggagagatct     1320

gtgagcagct gcgagctctg ggtgcctccc tggactggga tcgagagtgt tttaccatgg     1380

atgttggctc ctcagtggct gtgactgaag cttttgtgcg gctctacaag gcggggttgc     1440

tgtaccggaa ccatcagctt gtcaactggt catgtgcttt aagatcagcc atctcggaca     1500

ttgaggtgga gaaccggccc ctgcctggcc acacacagct tcgactgcct ggctgcccca     1560

cccccgtgtc ttttggcctc ctattttctg ttgccttccc cgtggatgga gagcctgatg     1620

cagaggttgt ggtaggaacc acaaggccag agacgctgcc tggagatgtg gctgtggccg     1680

ttcatccaga cgactcgcga tacacacatc tacacgggcg acagcttcgt caccccttga     1740

tggggcagcc tcttcccctc atcacagact atgctgttca gccacatgtg ggcacggggg     1800

cagtgaaggt gactccagct cacagtcctg ccgatgctga gatgggggcc cgacatggct     1860

tgagcccctt gaatgtcatt gcggaggatg ggaccatgac ctccctctgc ggggactggc     1920

tgcagggtct tcaccggttt gtggcccggg aaaagataat gtctgtgctg agtgaatggg     1980

gcctgttccg gggcctccag aaccacccca tggtactgcc catctgcagc cgttctgggg     2040

atgtgataga atacctgctg aagaaccagt ggtttgtccg ctgccaggaa atgggggccc     2100

gagctgccaa ggctgtggag tcgggggccc tggagctcag tccctccttc caccagaaga     2160

actggcagca ctggttttcc catattgggg actggtgtgt ctcccggcag ctgtggtggg     2220

gccatcagat tccagcctac ctggttgtag aggaccatgc gcagggagaa gaggactgtt     2280

gggtggttgg gcggtcagag gctgaggcca gagaggtagc agcggaactg acagggaggc     2340

caggggcaga gctgaccctg gagagggatc ctgatgtcct agacacatgg ttttcttctg     2400

ccctgttccc cttttctgcc ctgggctggc cccaagagac cccagacctt gctcgtttct     2460

accccctgtc acttttggaa acgggcagcg accttctgct gttctgggtg ggccgcatgg     2520

tcatgttggg gacccagctc acagggcagc tgcccttcag caaggtgctt cttcatccca     2580

tggttcggga caggcagggc cggaagatga gcaagtccct ggggaatgtg ctggacccaa     2640

gagacatcat cagtggggtg gagatgcagg tgctgcagga aaagctgaga agcggaaatt     2700

tggaccctgc agagctggcc attgtggctg cagcacagaa aaaggacttt cctcacggga     2760

tccctgagtg tgggacagat gccctgagat tcacactctg ctcccatgga gttcaggcgg     2820

gcgacttgca cctgtcagtc tctgaggtcc agagctgccg acatttctgc aacaagatct     2880

ggaatgctct tcgctttatc ctcaatgctt taggggagaa atttgtgcca cagcctgctg     2940

aggagctgtc tccctcctcc ccgatggatg cctggatcct gagccgcctt gccctggctg     3000

cccaggagtg tgagcggggc ttcctcaccc gagagctctc gctcgtcact catgccctgc     3060

accacttctg gcttcacaac ctctgtgacg tctacctgga ggctgtgaag cccgtgctgt     3120

ggcactcgcc ccgccccctg gggccccctc aggtcctgtt ctcctgcgct gacctcggcc     3180

tccgcctcct ggccccactg atgcccttcc tggctgaaga gctctggcag aggctgcccc     3240

ccaggcctgg ttgcccccct gcccccagca tctcggttgc cccctacccc agcgcctgca     3300

gcttggagca ctggcgccag ccagagctgg agcggcgctt ctcccgggtc caagaggtcg     3360

tgcaggtgct aagggctctc cgagccacgt accagctcac caaagcccgg ccccgagtgc     3420

tgctgcagag ctcagagcct ggggaccagg gcctcttcga ggccttcttg gagcccctgg     3480

gcaccctggg ctactgtggg gctgtgggcc tgttaccccc aggcgcagca gctccctccg     3540

gctgggccca ggctccactc agtgacacgg ctcaagtcta catggagctg cagggcctgg     3600

tggacccgca gatccagcta cctctgttag ccgcccgaag gtacaagttg cagaagcagc     3660

ttgacagcct cacagccagg accccatcag aaggggaggc agggactcag aggcaacaaa     3720

agctttcttc cctccagctg gaattgtcaa aactggacaa ggcagcctct cacctccggc     3780

agctgatgga tgagcctcca gccccaggga gcccggagct ctaactcatc atccccatca     3840

gttttcctcc ctctcagacc tgtctttgag gacaaacaga tttgtcagct gtcagggtgc     3900

agtgggacgt cagagactat gtggtccatc gccttcattg tgtaaatgag gacacagact     3960

ggcttggtcg cagtgactgt ggtgtccttg agatgctcac attactgccc ggcctgcctc     4020

ccacctggaa gtctgggaat gaggagattg agataaactt ttgaaatccc aaa            4073


<210> 2770
<211> 2394
<212> DNA
<213> Homo sapiens

<400> 2770
ggcttgaatc ccggcgcctc agaggactat gaggcgggcg ccaactgctt gggccgcagg       60

gcgggaggca gcgcgggagt ggggcgttga ggggccggcc tagcttgggg ctctggcctt      120

gcgtcttccg accgaatcac cgctcctgag cccggtgcgg ggctgccgct atcgcctggc      180

cgtgggtgcc ggagcggccg ggttgcgact cagcgttctt gggtgggcgc gggcggcgtc      240

tccgcggcgg gcatcccccg aggccgccct cgggccatga tcgactccgt gaagctgcgc      300

cgcgacagcg cggcggactt cttctcccac tacgagtacc tgtgcgcgct gcagaactcg      360

gtgccgctgc ccgccgtgcg cgcctgtctc cgggagggcg tgctggattt caacgccgac      420

cgcctccgcg gggtggactg ggcgcctctg ctgagcaccc tcaagatcaa taaagacctg      480

cccttggtct ccatcaagag cttcttccag ccctggctgg gggacacagg ttctgacatg      540

aataaatttt gcagaagtcg tgttcctgcg ataagataca aagatgtgac cttccagttg      600

tgtaaagctc ttaaaggctg tttaagtata tcaagtgtgc taaagaacct ggagctaaat      660

ggactaattc tgagagagag ggatttaact attctagcaa agggattgaa taaatcggct      720

tctttggtgc acctgtctct tgcaaattgt ccaattggag atggaggttt agaaattatt      780

tgtcaaggta taaagagctc tatcactctt aagacagtca acttcacagg atgtaatctg      840

acatggcagg gagcagatca catggccaag atcttaaagt atcagaccat gagaaggcat      900

gaagaaacct gggctgagag tcttcgctat aggagacctg atcttgactg tatggctggc      960

ttaagacgta tcacactgaa ttgcaacaca cttattggtg acctaggtgc atgtgctttt     1020

gcagactctc tcagtgagga tttatggctg agagctcttg acctgcaaca gtgcggcctc     1080

accaatgaag gagcaaaggc tttgctagag gcccttgaaa ccaatacaac tctggtcgtt     1140

ctggatataa gaaaaaatcc actcattgat cattctatga tgaaagcagt tatcaaaaaa     1200

gtcctccaga atggaaggag tgccaaatca gagtaccagt ggataacttc tccatcagtg     1260

aaggaaccat ccaaaactgc taaacagaaa aggagaacta taattctagg aagtggtcac     1320

aaaggaaaag ctactattag aattggattg gctacaaaga aacctgtaag tagtggcaga     1380

aaacactccc ttggtaaaga atattatgcg cccgcacctc ttccacctgg tgtgtctggt     1440

ttcttgccgt ggcgtactgc agaacgtgca aaaagacaca ggggtttccc attaatcaaa     1500

acacgtgata tatgtaatca gttgcagcaa ccaggttttc ctgtgactgt gacagtagag     1560

agtccttcat cctctgaagt tgaagaggtt gatgattctt cagagagtgt tcatgaagtg     1620

cctgagaaaa ctagtataga acaagaagca ttacaggaaa aactggagga gtgcctaaag     1680

cagttaaagg aagaaagagt gataaggctt aaggttgata aacgagtcag tgagctggaa     1740

catgaaaatg cccagttaag aaatataaat ttctctttgt ctgaagccct tcatgcacag     1800

tcattgacaa atatgatcct ggatgatgaa ggtgttttgg gcagcattga gaattctttt     1860

cagaagtttc atgctttctt ggatctcctt aaagatgctg ggcttgggca gcttgccaca     1920

atggctggga tagatcagtc agattttcaa ttactaggtc atccccagat gacttctact     1980

gttagtaatc cacctaaaga agaaaagaag gcgcttgaag atgaaaaacc agaaccgaag     2040

cagaatgccc tagggcaaat gcaaaatatc caggtttcta tttgtatgca gtcagcttac     2100

aatgaaggaa cactaatgaa gtttcagaaa attacaggtg atgctagaat tcctttgcct     2160

ctcgactcct ttcctgtccc agtttctact ccagagggct taggaacttc cagcaacaac     2220

ctaggagtcc cagctactga gcagcggcag gagtcttttg aaggattcat tgctagaatg     2280

tgttctcctt caccagatgc gacttctgga actggaagtc aaagaaaaga agaggagttg     2340

tccagaaata gcagatcttc ttcagagaaa aagaccaaaa caggaagcca ctaa           2394


<210> 2771
<211> 4285
<212> DNA
<213> Homo sapiens

<400> 2771
gcacttccgg gccggccgat tccgcgcgtc tccgcccatc atggcgctcg tgccagtgtc       60

ccgtgggcta cccactcctg tcatgtcctt tgggctggtg caggccagat cttctagggc      120

cgtagccctg agaggagcgc ctggagagga aacggcgcgc catgcacctc acacggcccc      180

tcagacctca cggcgaggcc ctatcagggt aatggtgtcc gccggactcg cacaacactc      240

cgccggactc gcacaacact ccgccgcact cgcacaagac tccgccgcgg cgacctctac      300

tgaaagaccc ccagtcctgg tgtcgcccga aggcccagga aaccgtgctt ccgcgcttct      360

cccccattta ccccagggtc gcaaaacatc tcaccgtagt tgaagccagc aagccggacc      420

aggcgtcccg gccaagccac gtgcgcgccc cgcgccgcga gtgctcgccc cgcccctagg      480

gaggagccgg ccgacccccg gccacttagc agtgccgcag ccgacggggt gcggttcggc      540

gctcccaggt tcctttcctc actgcacgct cttgcccctc ctcttttctc tcctgcccgt      600

gttcttcccg ccgcctgacc tggcccgccc gcctttccag tctggccggg cgggggcctg      660

aagcacggcg gctcgggccg tgggaccgtg ttcacaccct ttccagaaat tcttggctgg      720

taaccgcgaa accgactgga gcaggagctg ggagaactgg agaaaactgc tctaatctca      780

cttgactcca gctaggagct gatgctgcat cgtaataaca tttgcagagc gctttcacag      840

gcgctggagt gacttgtctg agattcctcc agaactgagc cctttgttgg aaccataccc      900

cagcccatgg tcccatgact aggtggatag tactccttgt acctcctgca acccagaacc      960

ctggctgacc actttgaagg aggatgctcc agcaggtcaa tggccacaat ccggggtctg     1020

atggccaagc cagggagtac ctcagagaag acctgcagga gttcctgggt ggggaggtcc     1080

tgctgtacaa actggatgac ctcaccaggg tgaatcctgt gacactagag acagtcctga     1140

ggtgcctgca ggcccggtac atggcagaca cattctacac caatgctggc tgcaccctgg     1200

tagccttgaa ccccttcaag cctgttcctc agctctactc gcccgagcta atgagagagt     1260

accatgctgc gcctcagccc cagaaactga agccccatgt gttcactgtg ggtgaacaga     1320

cctacaggaa tgtcaagagc ctgattgaac cagtcaacca gtctattgtt gtcagtggag     1380

agagtggtgc tggaaagaca tggacgtctc gctgcctaat gaagttctat gctgtggtgg     1440

ccacctcacc tgcatcttgg gagagccaca agattgcaga gaggatagaa cagaggatcc     1500

tgaactccaa ccctgtcatg gaagcttttg ggctcagcaa atgactggag ccgcagtcca     1560

gacctacctc ctagagaaaa ctcgagtggc ctgccaggct tccagtgaga ggaacttcca     1620

catcttctat cagatttgca aaggagccag tgaggacgag aggctccagt ggcaccttcc     1680

tgagggagct gccttctcct ggctgcccaa cccagagagg agcttagaag aggattgttt     1740

tgaggtgacc agagaggcca tgctccattt gggcattgac acccctaccc agaacaacat     1800

ctttaaggtc agaagaaaag ccacgccact taagtttggc agagatgacg ggcagccctt     1860

tgcatagagc ttttccctgg acttggagtt ggtctttccc tgaggatcta ggactttggg     1920

cccctctggg ctacctccaa ggaatcagtc acctctgttc tgctgagtct ggagaccagg     1980

tggtggggtg gacggggcat aaggaagagt gatgcataca cagtgctaga gtacagaatg     2040

cagtaagtga tccatggggg cagagagcaa ggtaccgcat gatcagaaga gagaactagt     2100

gctaccgcct tgcttgtcta gtacattaaa acttacaagt catgttcaca cttctctgct     2160

cacttagttt tttaaacagt cctctgtgtg tgtttatttc cctttatgcc tgagaaaacc     2220

agagaggtaa agtgacgtgc ccaaggtcag ataccactaa gtggtgatac agagtaccag     2280

acatagtaat tccaagttcc taccctctct gtcttccccc aacccgtgcc ccgtcgtcct     2340

ctggaacatg agactgcccc agagcagcag gaggggatag ataggatggc ctggcagtcg     2400

agaaagggag gccacttcag ggaggtagca atgcagtgga aagtgaccct cacctccaga     2460

tgggggctgc tcagacactg ccaggtccta gctggactgc tgcaccttgg caatatccag     2520

tttgctgcct ccgaggatga agcccagccc tgccagccga tggatgatgc caagtactct     2580

gtcaggacgg cagcctcgct gctggggctc ccagaggacg tgctgctgga gatggtgcag     2640

attagaacca tcagggcagg cagacagcag caggtgttcc ggaagccctg cgcccgagcc     2700

gagtgtgaca cccgtagaga ctgcctggcc aaactgatct atgcgcggtt gtttgactgg     2760

ctggtatcag tgatcaacag cagcatctgt gcagacaccg actcgtggac cactttcata     2820

ggcctgctgg atgtgtatgg atttgaatca tttcctgaca acagtctgga acagttgtgc     2880

atcaactacg ccaatgagaa gctgcagcag cattttgtgg ctcactacct aagggcccag     2940

caggaggaat acgcagttga gggcctggag tggtcattca tcaactacca ggacaaccag     3000

ccctgtttgg atctcattga gggaagcccc atcagcatct gctccctcat aaatgaggaa     3060

tgccgcctca atcgacccag cagcgcagcc cagctccaga cacgcattga gactgccctg     3120

gcaggcagcc cctgcctggg ccacaataag ctcagccggg agcccagctt cattgtggtg     3180

cattatgcgg ggcctgtgcg gtaccacaca gcaggcctgg tggagaagaa caaggaccct     3240

atcccacctg agctggatgg tgtggaagaa aaacacttct ctcaagctcc ctgttccctg     3300

agcacctcgc cgctgcagac caggctcctg gaggcaataa tccgcctctg gcccctggga     3360

ctggtcctgg ccaatacggc tatgggtgta ggcagctttc agaggaaatt agtggtctgg     3420

gcttgcctcc agctccccag gggcagcccc agtagctaca ctgtccagac agcacaagac     3480

caggctggtg tcacgtccat ccgagcgctg cctcagggat cgataaagtt tcactgcaga     3540

aagtctccac tgcggtatgc tgacatctgc cctgaacctt caccctacag cattacaggc     3600

tttaatcaga ttctgctgga aagacacagg ctgatccacg tgacctcttc tgccttcact     3660

gggctggggt gatccttggt gcctttgttt ccacaaggcc ttttcctgcc ccctgccttg     3720

ccaaagacat ttaatcagca cacagctgcc agactattcc cacagtgctc caaatgcaca     3780

tgaacaacag tgacggctcc agccttcgac ccagagcccc gtgcccagtg cgtcagtggg     3840

cctggggttc caggctacat caagcactga tggtgtcagg gctggtagtt accaaatcag     3900

ggttaagaaa catcagggcc acatttcact accttcacag atcaaactca gcagcagtca     3960

tgactgtctg tcactacact ggggatccca attccacata agcacttttg gaagaaaaca     4020

gccaaagttg gcctaaaatt ggcgctggaa tttgggctgg gaaaaatctt gtggttattt     4080

cctttaaaaa ggaacaaaac tttagtattt aattagttga tttatttaat gtaatttcaa     4140

acaattaaat tatgaataat gcaatgtaca gtagaatcac gttttgattt tattaacact     4200

gaccaagttt aactccatat gaagtgtaag cttgatatcg tttatgatgt ctatcaactg     4260

taccaaaagt aaaacattta aaaac                                           4285


<210> 2772
<211> 2268
<212> DNA
<213> Homo sapiens

<400> 2772
gttgtgacca gagcggttgc gggctgagcg gtttcgagcc ggcgtcgggg agcggcggta       60

ccgggcggct gcggggctgg ctcgacccag cttgaggtct cggcgtccgc gtcctgcggt      120

gccctggggt ctcccgagga ccttgtaccc gcgcggcttc cttgggctgg ctttggacga      180

cgctttcgcc ttcctgctgc ctaggatccg ccgacatgaa tcccatcgta gtggtccacg      240

gcggcggagc cggtcccatc tccaaggatc ggaaggagcg agtgcaccag ggcatggtca      300

gagccgccac cgtgggctac ggcatcctcc gggagggcgg gagcgccgtg gatgccgtag      360

agggagctgt cgtcgccctg gaagacgatc ccgagttcaa cgcaggttgt gggtctgtct      420

tgaacacaaa tggtgaggtt gaaatggatg ctagtatcat ggatggaaaa gacctgtctg      480

caggagcagt gtccgcagtc cagtgtatag caaatcccat taaacttgct cggcttgtca      540

tggaaaagac acctcattgc tttctgactg accaaggcgc agcgcagttt gcagcagcta      600

tgggggttcc agagattcct ggagaaaaac tggtgacaga gagaaacaaa aagcgcctgg      660

aaaaagagaa gcatgaaaaa ggtgctcaga aaacagattg tcaaaaaaac ttgggaaccg      720

tgggtgctgt tgccttggac tgcaaaggga atgtagccta cgcaacctcc acaggcggta      780

tcgttaataa aatggtcggc cgcgttgggg actcaccgtg tctaggagct ggaggttatg      840

ccgacaatga catcggagcc gtctcaacca cagggcatgg ggaaagcatc ctgaaggtga      900

acctggctag actcaccctg ttccacatag aacaaggaaa gacggtagaa gaggctgcgg      960

acctatcgtt gggttatatg aagtcaaggg ttaaaggttt aggtggcctc atcgtggtta     1020

gcaaaacagg agactgggtg gcaaagtgga cctccacctc catgccctgg gcagccgcca     1080

aggacggcaa gctgcacttc ggaattgatc ctgacgatac tactatcacc gaccttccct     1140

aagccgctgg aagattgtat tccagatgct agcttagagg tcaagtacag tctcctcatg     1200

agacatagcc taatcaatta gatctagaat tggaaaaatt gtcccgtctg tcacttgttt     1260

tgttgcctta ataagcatct gaatgtttgg ttgtggggcg ggttctgaag cgatgagaga     1320

aatgcccgta ttaggaggat tacttgagcc caggaggtca aagctgaggt gagccatgat     1380

tactccactg cactccagcc tgggcaacag agccaggccc tgtatcaaaa aaaaaaaaaa     1440

aaagaaaagg gaaaaaagaa agaaagcagc agcatgatcc tgacatgaca gatgtgggag     1500

acccacagcc tgcagacact gtgggctgga aggtgggaag ggaggggccg gtggaggtgg     1560

agctgtttga aagtgacaca gcagcagtag aagcagtggt gggcgaagcc caggtgaccc     1620

tcagaacgtt gcacaagaac atcagggaaa agaaccagaa tcctttaagg aaaatgttct     1680

tcatgtatga gagactaaag tgatttttct aagaaagttc agcccttctc tgacttacct     1740

ggacatttct agatacttcc aaaggaccct ctgggaatcc atagcttcct aatctggaga     1800

tgggaggtca taagggagac gctgtggggt tccttgaagt ttcttgggtt cacagaggag     1860

ccccctcact tggtgttctc ccgtgagcca gcctccacct gccaaagaca ctctggtcct     1920

cgtatagtga gtaatggggc tcagggcctc tccaacaaca gagaggagct gatgctgtag     1980

ggctgacccc gtgacttcct gagtcctcac cctgtccagt gctttgagat tcttcccacc     2040

tccccatcct caccagccgg atcgggcgct gtgcagtgtg gtcagcatgg tgaagaaagt     2100

catttcctcg gtgggcagta ttcctcttta tctctcatta cactggaaat gttatttctg     2160

ctgtatcatc cgtgctcaac gttttagtct gtcaggctca ccttctctct ggaaagaatt     2220

tgcttaactt gacattccat gtgccgctaa taaaatatat tttgaaag                  2268


<210> 2773
<211> 1220
<212> DNA
<213> Homo sapiens

<400> 2773
gaaactaggg gtcgggctcg gccgtcgtcg ttgtttgtcg ccgcatcccc gcttccgggt       60

taggccgttc ctgcccgccc cctcctctcc tcccttcgga cccatagatc tcaggctcgg      120

ctccccgccc gccgcagccc actgttgacc cggcccgtac tgcggccccg tggccaccat      180

gtccctgcac ggcaaacgga aggagatcta caagtatgaa gcgccctgga cagtctacgc      240

gatgaactgg agtgtgcggc ccgataagcg ctttcgcttg gcgctgggca gcttcgtgga      300

ggagtacaac aacaaggtgg tgattctaga tgtccgggtt ccctgcacac ctgtcgccag      360

gttaaacaac catcgagcat gtgtcaatgg cattgcttgg gccccacatt catcctgcca      420

catctgcact gcagcggatg accaccaggc tctcatctgg gacatccagc aaatgccccg      480

agccattgag gaccctatcc tggcctacac agctgaagga gagatcaaca atgtgcagtg      540

ggcatcaact cagcccgact ggatcgccat ctgctacaac aactgcctgg agatactcag      600

agtgtagtgt tggtggcgct gtgcccacga ggcaggggct tttgtatttc ctgcctctgc      660

cccaccccca aagtaagaag aaacatgttt ccagtggcca gtatgtcttt cattgctttg      720

cacccactgt taccagaagc tgctctagga gttcctggcc agtcacccca tcgccctctg      780

tggcagactc agtgctgtgt ggcgcctcct cagcccaggg ctgagtttta agattttctc      840

tcctttcctc ttctcctttg gttcctcaat taaaaaatgt gtgtatattt gtttgtcagg      900

cgttgtgttg aggagcagtt cacgcactgg ctgtgtctat tcctctgccc aggtgtctct      960

gtttgctgcc caaggcagca gttcatgtct cgtccatgtc catgttcgtg ttagcactta     1020

cgtgggaaca aataccaatt tgtcttttct cctagtatca gtgtgtttaa caaattttaa     1080

ctttgtatat ttgttatcta tcaggctaat ttttttatga aaagaatttt actctcctgc     1140

ttcatttctt tgtcttatag tcctccctct ttgcaccttc ttctcttccc tcagtgcctg     1200

gagctggtac tgggcccctg                                                 1220


<210> 2774
<211> 3772
<212> DNA
<213> Homo sapiens

<400> 2774
ggccgtgcga gaggccgagc ttgctgcatt gcagccgccg cggcgccgct cggctcttca       60

ctcccaacaa tggcggctcc gagcccgagc ggcggcggcg gctccggggg cggcagcggc      120

agcggcaccc ccggccccgt agggtccccg gcgccaggcc acccggccgt cagcagcatg      180

cagggctttc agataaactt ctgtgaaaag gcacaaagta aacgcaaagc actgaagttg      240

aattttgcaa atccaccttt caaatctaca gcaaggttta ctctgaatcc caatcctaca      300

ggagttcaaa acccacacat agagagactg agaacacaca gcattgagtc atcaggaaaa      360

ctgaagatct cccctgaaca acactgggat ttcactgcag aggacttgaa agaccttgga      420

gaaattggac gaggagctta tggttctgtc aacaaaatgg tccacaaacc aagtgggcaa      480

ataatggcag ttaaaagaat tcggtcaaca gtggatgaaa aagaacaaaa acaacttctt      540

atggatttgg atgtagtaat gcggagtagt gattgcccat acattgttca gttttatggt      600

gcactcttca gagagggtga ctgttggatc tgtatggaac tcatgtctac ctcgtttgat      660

aagttttaca aatatgtata tagtgtatta gatgatgtta ttccagaaga aattttaggc      720

aaaatcactt tagcaactgt gaaagcacta aaccacttaa aagaaaactt gaaaattatt      780

cacagagata tcaaaccttc caatattctt ctggacagaa gtggaaatat taagctctgt      840

gacttcggca tcagtggaca gcttgtggac tctattgcca agacaagaga tgctggctgt      900

aggccataca tggcacctga aagaatagac ccaagcgcat cacgacaagg atatgatgtc      960

cgctctgatg tctggagttt ggggatcaca ttgtatgagt tggccacagg ccgatttcct     1020

tatccaaagt ggaatagtgt atttgatcaa ctaacacaag tcgtgaaagg agatcctccg     1080

cagctgagta attctgagga aagggaattc tccccgagtt tcatcaactt tgtcaacttg     1140

tgccttacga aggatgaatc caaaaggcca aagtataaag agcttctgaa acatcccttt     1200

attttgatgt atgaagaacg tgccgttgag gtcgcatgct atgtttgtaa aatcctggat     1260

caaatgccag ctactcccag ctctcccatg tatgtcgatt gatatcgctg ctacatcaga     1320

ctctagaaaa aagggctgag aggaagcaag acgtaaagaa ttttcatccc gtatcacagt     1380

gtttttattg ctcgcccaga caccatgtgc aataagattg gtgttcgttt ccatcatgtc     1440

tgtatactcc tgtcacctag aacgtgcatc cttgtaatac ctgattgatc acacagtgtt     1500

agtgctggtc agagagacct catcctgctc ttttgtgatg aacatattca tgaaatgtgg     1560

aagtcagtac gatcaagttg ttgactgtga ttagatcaca tcttaaattc atttctagac     1620

tcaaaacctg gagatgcagc tactggaatg gtgttttgtc agacttccaa atcctggaag     1680

gacacagtga tgaatgtact atgtctgaac atagaaactc gggcttgagt gagaagagct     1740

tgcacagcca acgagacaca ttgccttctg gagctgggag acaaaggagg aatttacttt     1800

cttcaccaag tgcaatagat tactgatgtg atattctgtt gctttacagt tacagttgat     1860

gtttggggat cgatgtgctc agccaaattt cctgtttgaa atatcatgtt aaattagaat     1920

gaatttatct ttaccaaaaa ccatgttgcg ttcaaagagg tgaacattaa aatatagaga     1980

caggacagaa tgtgttcttt tctcctttac cagtcctatt tttcaatggg aagactcagg     2040

agtctgccac ttgtcaaaga aggtgctgat cctaagaatt tttcattctc agaattcggt     2100

gtgctgccaa cttgatgttc cacctgccac aaaccaccag gactgaaaga agaaaacagt     2160

acagaaggca aagtttacag atgtttttaa ttctagtatt ttatctggaa caacttgtag     2220

cagctatata tttccccttg gtcccaagcc tgatacttta gccatcataa ctcactaaca     2280

gggagaagta gctagtagca atgtgccttg attgattaga taaagatttc tagtaggcag     2340

caaaagacca aatctcagtt gtttgcttct tgccatcact ggtccaggtc ttcagtttcc     2400

gaatctcttt cccttcccct gtggtctatt gtcgctatgt gacttgcgct taatccaata     2460

ttttgccttt tttctatatc aaaaaacctt tacagttagc agggatgttc cttaccaagg     2520

atttttagcc ccaaatctct catattcgct agtgtttaaa aggctaagaa tagtggggcc     2580

cagccgatgt ggtaggtgat aaagaggcat cttttctaga gacacattgg accagatgag     2640

gatccgaaac ggcagccttt acgttcatca cctgctagaa cctctcgtag tccatcacca     2700

tttcttggca ttggaattct actggaaaaa aatacaaaaa gcaaaacaaa accctcagca     2760

ctgttacaag aggccattta agtatcttgt gcttcttcac ttacccatta gccaggttct     2820

cattaggttt tgcttgggcc tccctggcac tgaaccttag gctttgtatg acagtgaagc     2880

agcactgtga gtggttcaag cacactggaa tataaaacag tcatggcctg agatgcaggt     2940

gatgccatta cagaaccaaa tcgtggcacg tattgctgtg tctcctctca gagtgacagt     3000

cataaatact gtcaaacaat aaagggagaa tggtgctgtt taaagtcaca tccctgtaaa     3060

ttgcagaatt caaaagtgat tatctctttg atctacttgc ctcatttccc tatcttctcc     3120

cccacggtat cctaaacttt agacttccca ctgttctgaa aggagacatt gctctatgtc     3180

tgccttcgac cacagcaagc catcatcctc cattgctccc ggggactcaa gaggaatctg     3240

tttctctgct gtcaacttcc catctggctc agcatagggt cactttgcca ttatgcaaat     3300

ggagataaaa gcaattctga ctgtccagga gctaatctga ccgttctatt gtgtggatga     3360

ccacataaga aggcaatttt agtgtattaa tcatagatta ttataaacta taaacttaag     3420

ggcaaggagt ttattacaat gtatctttat taaaacaaaa gggtgtatag tgttcacaaa     3480

ctgtgaaaat agtgtaagaa ctgtacattg tgagctctgg ttatttttct cttgtaccat     3540

agaaaaatgt ataaaaatta tcaaaaagct aatgtgcagg gatattgcct tatttgtctg     3600

taaaaaatgg agctcagtaa cataactgct tcttggagct ttggaatatt ttatcctgta     3660

ttcttgtttg aattcctcct ctatttaaga tatatacatg gaatcgaagt gtttatgtaa     3720

tagttctatc cttttgcctg caggtcagtt gtaataaatc taggatgtga tg             3772


<210> 2775
<211> 993
<212> DNA
<213> Homo sapiens

<400> 2775
ccagccactg cggcaggaag caagaggaag ttaacatccc taataggagg gttctggtta       60

ctggtgccac tgggcttctt ggcagagctg tacacaaaga atttcagcag aataattggc      120

atgcagttgg ctgtggtttc agaagagcaa gaccaaaatt tgaacaggtt aatctgttgg      180

attctaatgc agttcatcta cattagctca gattatgtat ttgatggaac aaatccacct      240

tacagagagg aagacatacc agctccccta aatttgtatg gcaaaacaaa attagatgga      300

gaaaaggctg tcctggagaa caatctagga gctgctgttt tgaggattcc tattctgtat      360

ggggaagttg aaaagctcga agaaagtgct gtgactgtta tgtttgataa agtgcagttc      420

agcaacaagt cagcaaacat ggatcactgg cagcagaggt tccccacaca tgtcaaagat      480

gtggccactg tgtgccggca gctagcagag aagagaatgc tggatccatc aattaaggga      540

acctttcact ggtctggcaa tgaacagatg actaagtatg aaatggcatg tgcaattgca      600

gatgccttca acctccccag cagtcactta agacctatta ctgacagccc tgtcctagga      660

gcacaacgtc cgagaaatgc tcagcttgac tgctccaaat tggagacctt gggcattggc      720

caacgaacac catttcgaat tggaatcaaa gaatcacttt ggcctttcct cattgacaag      780

agatggagac aaacggtctt tcattagttt atttgtgttg ggttcttttt tttttttaaa      840

tgaaaagtat agtatgtggc actttttaaa gaacaaagga aatagttttg tatgagtact      900

ttaattgtga ctcttaggat ctttcaggta aatgatgctc ttgcactagt gaaattgtct      960

aaagaaacta aagggcagtc atgccctgtt tgc                                   993


<210> 2776
<211> 3195
<212> DNA
<213> Homo sapiens

<400> 2776
agtcggcctg cgctcctcag cctggcggtt ctacctccga gggttcgccc gcccttggtt       60

ttccttacac cttagccttt ggctcctttg accactcgaa gccccacagc gtgttccagc      120

ggacttcacc agcagaccca gaagtggtgg gtgaaacact gcctctgttc ctccttgagc      180

ctgtcgggag ctgctgcctg ccaccaccat gtctgctgca aatcctgaga ctccaaactc      240

aaccatctcc agagaggcca gcacccagtc ttcatcagct gcagctagcc aaggctgggt      300

gttaccagaa ggcaaaatcg tgccaaacac tgtttttgtt ggtggaattg atgctaggat      360

ggatgaaact gagattggaa gctgctttgg tagatacggt tcagtgaaag aagtgaagat      420

aatcacgaat cgaactggtg tgtccaaagg ctatggattt gtttcgtttg ttaatgacgt      480

ggatgtccag aagatagtag gatcacagat acatttccat ggtaaaaagc tgaagctggg      540

ccctgcaatc aggaaacaaa agttatgtgc tcgtcatgtg cagccacgtc ctttggtagt      600

taatcctcct cctccaccac agtttcagaa cgtctggcgg aatccaaaca ctgaaaccta      660

cctgcagccc caaatcacgc cgaatcctgt aactcagcac gttcaggctt actctgctta      720

tccacattca ccaggtcagg tcatcactgg atgtcagttg cttgtatata attatcagga      780

atatcctact tatcccgatt cagcatttca ggtcaccact ggatatcagt tgcctgtata      840

taattatcag ccatttcctg cttatccaag ttcaccattt caggtcactg ctggatatca      900

gttgcctgta tataattatc aggcatttcc tgcttatcca agttcaccat ttcaggtcac      960

cactggatat cagttgcctg tatataatta tcaggcattt cctgcttatc caagttcacc     1020

atttcaggtc accactggat atcagttgcc tgtatataat tatcaggcat ttcctgctta     1080

tccaagttca ccatttcagg tcaccactgg atatcagttg cctgtatata attatcaggc     1140

atttcctgct tatccaaatt cagcagttca ggtcaccact ggatatcagt tccatgtata     1200

caattaccag atgccaccgc agtgccctgt tggggagcaa aggagaaatc tgtggaccga     1260

agcatacaaa tggtggtatc ttgtctgttt aatccagaga agagactgat aaattccgtt     1320

gttactcaag atgactgctt caagggtaaa agagtgcatc gctttagaag aagtttggca     1380

gtatttaaat ctgttggatc ctctcagcta tctagtttca tgggaagttg ctggttttga     1440

atattaagct aaaagttttc cactattaca gaaattctga attttggtaa atcacactga     1500

aactttctgt ataacttgta ttattagact ctctagtttt atcttaacac tgaaactgtt     1560

cttcattaga tgtttattta gaacctggtt ctgtgtttaa tatatagttt aaagtaacaa     1620

ataatcgaga ctgaaagaat gttaagattt atctgcaagg atttttaaaa aattgaaact     1680

tgcattttaa gtgtttaaaa gcaaatactg actttcaaaa aagtttttaa aacctgattt     1740

gaaagctaac aattttgata gtctgaacac aagcatttca cttctccaag aagtacctgt     1800

gaacagtaca atatttcagt attgagcttt gcatttatga tttatctaga aatttacctc     1860

aaaagcagaa tttttaaaac tgcattttta atcagtggaa ctcaatgtat agttagcttt     1920

attgaagtct tatccaaacc cagtaaaaca gattctaagc aaacagtcca atcagtgagt     1980

cataatgttt attcaaagta ttttatcttt tatctagaat ccacatatgt atgtccaatt     2040

tgattgggat agtagttagg ataactaaaa ttctgggcct aattttttaa agaatccaag     2100

acaaactaaa ctttactggg tatataacct tctcaatgag ttaccattct tttttataaa     2160

aaaaattgtt ccttgaaatg ctaaacttaa tggctgtatg tgaaatttgc aaaatactgg     2220

tattaaagaa cgctgcagct tttttatgtc actcaaaggt taatcggagt atctgaaagg     2280

aattgttttt ataaaaacat tgaagtatta gttacttgct ataaatagat ttttattttt     2340

gttttttagc ctgttatatt tccttctgta aaataaaata tgtccagaag aggcatgttg     2400

tttctagatt aggtagtgtc ctcattttat attgtgacca cacagctaga gcaccagagc     2460

ccttttgcta tactcacagt cttgttttcc cagcctcttt tactagtctt tcaggaggtt     2520

tgctcttaga actggtgatg taaagaatgg aagtagctgt atgagcagtt caaaggccaa     2580

gccgtggaat ggtagcaatg ggatataata cctttctaag ggaaacattt gtatcagtat     2640

catttgatct gccatggaca tgtgtttaaa gtggctttct ggcccttctt tcaatggctt     2700

cttccctaaa acgtggagac tctaagttaa tgtcgttact atgggccata ttactaatgc     2760

ccactggggt ctatgatttc tcaaaatttt cattcggaat ccgaaggata cagtctttaa     2820

actttagaat tcccaagaag gctttattac acctcagaaa ttgaaagcac catgactttg     2880

tccattaaaa aattatccat agttttttta gtgcttttaa cattccgaca tacatcattc     2940

tgtgattaaa tctccagatt tctgtaaatg atacctacat tctaaagagt taattctaat     3000

tattccgata tgaccttaag gaaaagtaaa ggaataaatt tttgtctttg ttgaagtatt     3060

taatagagta aggtaaagaa gatattaagt ccctttcaaa atggaaaatt aattctaaac     3120

tgagaaaaat gttcctacta cctattgctg atactgtctt tgcataaatg aataaaaata     3180

aacttttttt cttca                                                      3195


<210> 2777
<211> 712
<212> DNA
<213> Homo sapiens

<400> 2777
tctcggtctg tccgctgggg gcgcgcgcgg tgtgtggcag gcggcagcgg cgctggcggc       60

cgagtgcgct tgtcacgcgt ggcggtgcgt ggttgctagg ggcgcctgag gctgccgggt      120

agcccagcag gccgagggag gaagtagcgt ggagccggtg ccgagccggg gcgaagctgg      180

atcccctaga tagactgtct tcaagctcac tgatattttc ctctgcttga tccattgtgc      240

tgttgagagc ctctagtaaa tttttcaggt cactacctct ttttcaacac tagatggcat      300

cttggcccca gactgacaga cttcaaggat gcagctgcta ctaccggagg tgtgtggcac      360

cttacctcag caaggccatg agaccgtgtg gccatgatgt gggcccctca tggcctcagc      420

aggaacacag cactatagta ttggcctccg ccagaaaaac agcttcaagc agagtggtcc      480

ctcaggcaca gtacctgcca cgccacctga gaaaccctcg gagggcagag tctggcctca      540

ggcccatcag caagtgaagc caatctggaa gctggaaaag aagcaagtgg agacactgtc      600

agcagggttg ggcccaggcc tcttgggcgt cccaccccag ccagcatatt tcttttgccc      660

cagcacttta tgtagctctg ggaccacggc tgtcattgca ggccacagca gt              712


<210> 2778
<211> 2623
<212> DNA
<213> Homo sapiens

<400> 2778
tgaggggccg gcctagcttg gggctctggc cttgcgtctt ccgaccgaat caccgctcct       60

gagcccggtg cggggctgcc gctatcgcct ggccgtgggt gccggagcgg ccgggttgcg      120

actcagcgtt cttgggtggg cgcgggcggc gtctccgcgg cgggcatccc ccgaggccgc      180

cctcgggcca tgatcgactc cgtgaagctg cgccgcgaca gcgcggcgga cttcttctcc      240

cactacgagt acctgtgcgc gctgcagaac tcggtgccgc tgcccgccgt gcgcgcctgt      300

ctccgggagg gcgtgctgga tttcaacgcc gaccgcctcc gcggggtgga ctgggcgcct      360

ctgctgagca ccctcaagat caataaagac ctgcccttgg tctccatcaa gagcttcttc      420

cagccctggc tgggggacac aggttctgac atgaataaat tttgcagaag tcgtgttcct      480

gcgataagat acaaagatgt gaccttccag ttgtgtaaag ctcttaaagg ctgtttaagt      540

atatcaagtg tgctaaagaa cctggagcta aatggactaa ttctgagaga gagggattta      600

actattctag caaagggatt gaataaatcg gcttctttgg tgcacctgtc tcttgcaaat      660

tgtccaattg gagatggagg tttagaaatt atttgtcaag gtataaagag ctctatcact      720

cttaagacag tcaacttcac aggatgtaat ctgacatggc agggagcaga tcacatggcc      780

aagatcttaa agtatcagac catgagaagg catgaagaaa cctgggctga gagtcttcgc      840

tataggagac ctgatcttga ctgtatggct ggcttaagac gtatcacact gaattgcaac      900

acacttattg gtgacctagg tgcatgtgct tttgcagact ctctcagtga ggatttatgg      960

ctgagagctc ttgacctgca acagtgcggc ctcaccaatg aaggagcaaa ggctttgcta     1020

gaggcccttg aaaccaatac aactctggtc gttctggata taagaaaaaa tccactcatt     1080

gatcattcta tgatgaaagc agttatcaaa aaagtcctcc agaatggaag gagtgccaaa     1140

tcagagtacc agtggataac ttctccatca gtgaaggaac catccaaaac tgctaaacag     1200

aaaaggagaa ctataattct aggaagtggt cacaaaggaa aagctactat tagaattgta     1260

ggattggcta caaagaaacc tgtaagtagt ggcagaaaac actcccttgg taaagaatat     1320

tatgcgcccg cacctcttcc acctggtgtg tctggtttct tgccgtggcg tactgcagaa     1380

cgtgcaaaaa gacacagggg tttcccatta atcaaaacac gtgatatatg taatcagttg     1440

cagcaaccag gttttcctgt gactgtgaca gtagagagtc cttcatcctc tgaagttgaa     1500

gaggttgatg attcttcaga gagtgttcat gaagtgcctg agaaaactag tatagaacaa     1560

gaagcattac aggaaaaact ggaggagtgc ctaaagcagt taaaggaaga aagagtgata     1620

aggcttaagg ttgataaacg agtcagtgag ctggaacatg aaaatgccca gttaagaaat     1680

ataaatttct ctttgtctga agcccttcat gcacagtcat tgacaaatat gatcctggat     1740

gatgaaggtg ttttgggcag cattgagaat tcttttcaga agtttcatgc tttcttggat     1800

ctccttaaag atgctgggct tgggcagctt gccacaatgg ctgggataga tcagtcagat     1860

tttcaattac taggtcatcc ccagatgact tctactgtta gtaatccacc taaagaagaa     1920

aagaaggcgc ttgaagatga aaaaccagaa ccgaagcaga atgccctagg gcaaatgcaa     1980

aatatccagt ttcagaaaat tacaggtgat gctagaattc ctttgcctct cgactccttt     2040

cctgtcccag tttctactcc agagggctta ggaacttcca gcaacaacct aggagtccca     2100

gctactgagc agcggcagga gtcttttgaa ggattcattg ctagaatgtg ttctccttca     2160

ccagatgcga cttctggaac tggaagtcaa agaaaagaag aggagttgtc cagaaatagc     2220

agatcttctt cagagaaaaa gaccaaaaca ggtgaatata ccaaaaaaca ctctgataag     2280

caacaccctg gaaaggacct gcattcctga tctgactgtc ctgaaaacca gaaaagcaaa     2340

gaaactaggg aaactagttc tttggttaat gaaccaatta aaagtaggtc tttgaaaaaa     2400

tacgtttctg tcaagaaaga aaatagaata gtgactgttt catccaagac aaataaaagt     2460

aaatccagtc cactagaaca ttctgaaagt gatactcttg gatgtgattt tgaatttcaa     2520

gaaagcatcc attctctatc acacctttca tatgactaaa tcttttgaaa ctatgttttt     2580

acctttaaat tttaataaat tttcttatgt ttttattatg gca                       2623


<210> 2779
<211> 2015
<212> DNA
<213> Homo sapiens

<400> 2779
cggctgtacg ctaccacagc ttcccaggcc gcgggtgctg attgcccgcc tgcccgtggg       60

tcatggcctg ccagcagtcg cggtaccaca gcttctcgtc cgcgtcgaga ttacagccac      120

ggccttcagg agtgaccata gacgaatcct ttctcacaga agacaagagc acccagaatc      180

gcaagcttct tcagaaacga aggacgctgg agctgccagc agcacccctt tcgcactgcc      240

aagccccagt acttggagga actggaaaac tacctacgca aggagctcct cctgctggac      300

ctgggcacag attccaccca ggaactaagg ctgcagccca ccaaagggag aagattcggg      360

ctctggagcc cctgaaggcc aagcttgtca ctgtgaatga ggactgcaat gagaggatcc      420

tggccatgag agctgaggag aaatatgaaa tctccctgct caagaaagag aagatgaact      480

tgctaaaact catcgacaaa aagaatgagg agaagatttc attgcagagc gaggtgacca      540

aactgaggaa gaacttggct gaggagtacc tgcactacct cagtgagcga gatgcctgta      600

agatcctcat cgcagacctg aatgagctgc ggtaccagcg ggaggacatg tcattagccc      660

agtcgccagg catctggggg gaggaccctg tgaagttaac cctggctctt aagatgaccc      720

ggcaagacct gacccgcacg cagatggaac tcaacaacat gaaggccaac tttggagatg      780

tggtccccag gagggacttt gaaatgcagg agaagaccaa caaggatctt caggagcagc      840

tggacaccct gagagccagc tacgaggagg ttcgcaagga gcatgagatc ctcatgcagc      900

tgcacatgag cacgctgaag gaacgggacc aattcttctc tgagctgcag gagatccagc      960

gcacttccac gccgcggcct gactggacca agtgcaaaga tgtggtggct gggggcccag     1020

agcgctggca gatgctggct gagggcaaga acagcgacca gctggtggac gtgctcctgg     1080

aagagattgg ttcggggctg ctgcgggaga aagacttctt ccctggtctg ggctatgggg     1140

aagccatccc tgcttttctt cggtttgatg gcctcgtgga gaacaagaag ccaagcaaga     1200

aggacgtggt caacctcctc aaggatgcct ggaaggaacg tcttgctgag gagcagaaag     1260

agacgttccc agatttcttc ttcaatttcc tggagcatcg ctttgggccc agtgatgcca     1320

tggcctgggc ttatactatt tttgaaaata tcaagatctt ccactccaac gaggttatga     1380

gtcagttcta tgcagtcttg atgggaaagc ggagtgagaa tgtgtatgtc acccagaagg     1440

agacagtagc ccagctgctg aaggagatga caaatgctga cagtcagaac gaggggctac     1500

taaccatgga gcagttcaac actgtcctca agagtacctt ccctctcaag acagaagagc     1560

aaatccagga gctgatggag gcagggggct ggcatcccag cagcagcaat gcagacttgc     1620

tcaactaccg ctcactgttt atggaggatg aggagggcca gagtgagccc tttgtgcaaa     1680

aactctggga acaatacatg gatgagaagg acgagtactt acagcagcta aagcaggagc     1740

ttggcataga actccatgag gaagtgactc tgcccaagct gcgagggggc ctgatgacca     1800

tcgaccccag cctggacaag cagacagtga acacctacat gagccaggcc ttccagctcc     1860

ctgagtcgga aatgccagag gagggtgacg agaaggaaga agccgtggtg gaaatcctcc     1920

agactgccct ggagcggctt caggtgattg acatcaggcg tgtgggacct cgagagccag     1980

agcctgcaag ctaggaactt gtgggcagcc tgcgt                                2015


<210> 2780
<211> 603
<212> DNA
<213> Homo sapiens

<400> 2780
gtgcaggagc gggacccgga acagaccgcc gtgagagagg aggggcgccg gccgggattc       60

gcggcccgga gctcgggacc ggagaagaag tcctcaccag tgaacggaga cctctctgaa      120

ctaaggatac catggccacg tcagccccac tacggagcct ggaagaggag gtgacctgct      180

ccatctgtct tgattacctg cgggaccctg tgaccattga ctgtggccac gtcttctgcc      240

gcagctgcac cacagacgtc cgccccatct cagggagccg ccccgtctgc ccactctgca      300

agaagccttt taagaaggag aacatccgac ccgtgtggca actggccagc ctggtggaga      360

acattgagcg gctgaaggtg gacaagggca ggcagccggg agaggtgacc cgggagcagc      420

aggatgcaaa gttgtgcgag cgacaccgag agaagctgca ctactactgt gaggacgacg      480

ggaagctgct gtgcgtgatg tgccgggagt cccgggagca caggccccac acggccgtcc      540

tcatggagaa ggccgcccag ccccacaggg aaaaaatcct gaaccacctg agtaccctaa      600

gga                                                                    603


<210> 2781
<211> 2678
<212> DNA
<213> Homo sapiens

<400> 2781
caaagcagac ctcacctccc actaccagct tgaagtcaca gcagccagag gaaattctgc       60

caccattttc ccaggtctgc agcccctcca gctgggaacc tgctcctgga gccatccctc      120

tgcaaacaga gagcccagag tgcctcgggg aaaattggct gaataaaaga gcgatcagga      180

cgccacggct ccgcctgaag cgatggccca gccctacccc cccgcccagt acccccctcc      240

gccacagaac ggcatccctg ccgagtacgc cccgccccca ccgcacccca cgcaggacta      300

ctccggccag accccggtcc ccacagagca tggcatgacc ctgtacacac cagcacagac      360

ccaccccgag cagccaggct ccgaggccag cacacagccc atcgccggga cccagacagt      420

gccgcagaca gacgaggcgg cacagacgga cagccagccg ctccacccct ccgaccctac      480

agagaagcag cagcccaagc ggctacacgt ctccaacatc cccttccggt tcagggaccc      540

cgacttgcgg caaatgttcg ggcaattcgg aaaaatttta gacgtggaga tcatttttaa      600

cgagcggggc tccaagggtt ttgggtttgt aacttttgaa actagctcag atgctgaccg      660

agcccgggag aagctgaatg ggacgatcgt agagggacgg aaaattgagg tcaataatgc      720

cacggcccga gtgatgacca acaagaagac ggggaacccc tacaccaacg gctggaagct      780

aaatccagtg gtcggcgcag tctacgggcc tgaattctat gcagtgacgg ggttccccta      840

ccccaccacc ggcacagccg ttgcctaccg gggcgcacat cttcggggcc ggggccgggc      900

cgtgtataat acatttcggg ctgcgccacc cccacccccc atcccgactt acggagcggt      960

cgtgtatcag gatggatttt atggtgctga gatttatgga ggctacgcag cctacagata     1020

cgctcagccc gctgcagcgg cggcagccta cagcgacagt tacggcagag tctacgcagc     1080

tgccgacccg taccatcaca ccatcgggcc cgcggcgacc tacagcattg gaaccatgtg     1140

aaaccttcca ccgtttcctt ctcggaccat gaagggcaaa aacaaaaaaa caaaaaaaat     1200

cacaaaacaa aaaaaacaaa aaaagatgtt aagatccaag caacaaaaaa aaaaccaacc     1260

aaaccaagag gcatccaacc aagtccaagt cccgcgtcct ggccacacgc ccgcaccgag     1320

ggagcacgcc ggcaggggcg ccgaggagcg gccccaggac aggacggccc caccgcgtcc     1380

tggctggcag cacagtggga acacgcccct ccgtctcagg cagtggggga gttggagggg     1440

aaggggcctc ccttgtggga cccgtggggg gctctgtttt ccatccagtc ttcctttccc     1500

agcccccaac tcccaagaca gacagtgtgg agcccagcgg cggcggagca ggcccgggcc     1560

tgagcaggca ggcgctgcta gcaagacttg atctttgtgg ccagctgtgc cagggggccg     1620

gcggggctga ggggtgcggg cagctttcat cccaggggct ccactgggcc ccgtcaccct     1680

cctgtcgcgt cccctgcgtc ccacctccct cctgcccggc agtcccgccc gtgcccccag     1740

cctggcgagg aagccgtcca acagtagccc cggggccagc tcccaacaga aagggctgac     1800

gtggctccag gactcagggg cgctccatgg gaggacgaag gaagcccagc cagccaggag     1860

ccactcctca cacctccaag tgtggccaag tgggccctga ggccaaggac ttacttgctc     1920

ttcctggcca tctctccctt tctggaggag gcccggggcc tgtgtacacc aaggctgacc     1980

tcgtgctgcc tgctgggacc cagccctccc tgccgctccc ctgtgagccc agtccaccgt     2040

gggcgcccag ggccagggac gggccagcgc ccggctgcat cgcgaggttg ggagtcacag     2100

tggctgtggg cctggacggg cacagccaga gcaggggccc atgggaaggg caagggatgg     2160

ggaagcctgg gccggcccct tccctgctcc caaggcaggt gtccaggtgg cgggagcagc     2220

accaaggaca gccaggctta cccggtggga ggagcaggag cagagcaggt ggcagggagg     2280

aacccctggc gaggcaggga gcactgaagt agggaagcag caaaaaatac aggctcccaa     2340

cgtggctcca ctgtctcatg aagtgtcaaa aatttaaaaa tacacctcac tttctattca     2400

gcatcagcta ttgaaatgga attctccttt tctattcccg ttgtacatag ccccacgccc     2460

tgcctccggc tttgtcctct gtacagagcc ccctgtcccc tctgctgttc cggacccttt     2520

tcttgcagca gctcaacccc ccgactcact cagatcccca ggactgcagc cgagccccgg     2580

gcttcctttc ttaccattct gtatgcttcc aaggtgtgac cattcaaact aacagtatta     2640

ttaagattat taataaagat ttctttcttc aaaccagg                             2678


<210> 2782
<211> 556
<212> DNA
<213> Homo sapiens

<400> 2782
agaagcaagg gagtagacaa aatgattctc ttctttcttg cccctcagag agacctgaga       60

caccctgaat cccactgtaa tctccttggt gccattggta actctgccaa agtccatctc      120

taggtgacat gaagtctctt agaaattgag gaccaaattg cgctctgcag ctctgggcta      180

cttcccatct cattttgtgt ccctattttc gtatctgtat tagagaggtg atctggtgcc      240

agctggtgga acagtgggtg atggcgtccc tgctgcaaga ccagctgacc actgatcagg      300

acttgctgct gatgcaggaa ggcatgccga tgcgcaaggt gaggtccaaa agctggaaga      360

agctaagata cttcagactt cagaatgacg gcatgacagt ctggcatgca cggcaggcca      420

ggggcagtgc caagcccagc ttctcaatct ctgatgtgga gacaatacgt aatggccatg      480

attccgagtt gctgcgtagc ctggcagagg agctccccct ggagcagggc ttcaccattg      540

tcttccatgg ccgccg                                                      556


<210> 2783
<211> 3478
<212> DNA
<213> Homo sapiens

<400> 2783
aacagaccgc cgtgagagag gaggggcgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg tgttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cggttgcttc      180

attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt      240

gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc tgtcgattga      300

ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt actgtgcttg      360

ctcctgactc tacgtcgcgt ctccaaggag aagaagtcct caccagtgaa cggagacctc      420

tctgaactaa ggataccatg gccacgtcag ccccactacg gagcctggaa gaggaggtga      480

cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt ggccacgtct      540

tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc gtctgcccac      600

tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg gccagcctgg      660

tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag gtgacccggg      720

agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac tactgtgagg      780

acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg      840

ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac cacctgagta      900

ccctaaggag agacagagac aaaattcagg gcttccaggc aaagggagaa gctgatatcc      960

tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag tttgagcagg     1020

gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg aagctggagc     1080

aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag cttgcccggc     1140

tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca gagctcatgc     1200

aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt gggaaaccca     1260

ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc tctctgcaac     1320

gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag acagtgagcg     1380

tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac tggaagtgcg     1440

tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt gactgtgagc     1500

ctggggtgct gggcagcaag ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg     1560

agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag ggagaagagg     1620

aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa acggacgaag     1680

atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag gaagttctgg     1740

aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac ctctccctgc     1800

ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg gccaacacca     1860

gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc gccctggatt     1920

atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc tacaccttca     1980

ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca ggaacacgcc     2040

tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag atgcttcact     2100

tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag cacctggagc     2160

aggggacccc atatccactg gtagccacct ccccattgct gtggccccct gaaatctcac     2220

tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc ctgctggttt     2280

cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg accacgacct     2340

tggccccagc tctgcactct ctggaataag ggcccgatgc agcattttct tgcccagtgt     2400

ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt ccttaaaccc     2460

cccaggttcc ttcttgcaca aatccactct gctgcccacc ttctctggca ttttaaacag     2520

acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat aaacaaaatc     2580

cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat ctcatggggt     2640

ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat agccaaggag     2700

gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac acggctttgg     2760

ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg tgaggggagt     2820

tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca agacaaacat     2880

ccagtggagc agaacctctc ctgcctcggg agttctgacc gggttcccca gcagggtgtt     2940

aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag agagtggaga     3000

tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa     3060

gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca ggtgcccctc     3120

atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc agtcttgtcc     3180

ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc ctccaccctg     3240

ttctaagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac cattgtctca     3300

gagctgccca ctttgtgtgt gtcacatgct gcctgagtca catgtacatc ttatttctgc     3360

ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt gtattctcat     3420

ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt tgaatgaa       3478


<210> 2784
<211> 682
<212> DNA
<213> Homo sapiens

<400> 2784
ggaaacctgt tgagatcaca gagaatatac tgacggcata aaagggcaga accatagcag       60

ggtgcgcctc gcagtcacct ctgtgccctg ctggttgtct tcccagcgct gctgtagttg      120

ccttccatgg atctatagga gagcaagtcc tccaggagaa gaagtcctca ccagtgaacg      180

gagacctctc tgaactaagg ataccatggc cacgtcagcc ccactacgga gcctggaaga      240

ggaggtgacc tgctccatct gtcttgatta cctgcgggac cctgtgacca ttgactgtgg      300

ccacgtcttc tgccgcagct gcaccacaga cgtccgcccc atctcaggga gccgccccgt      360

ctgcccactc tgcaagaagc cttttaagaa ggagaacatc cgacccgtgt ggcaactgga      420

aaaaatcctg aaccacctga gtaccctaag gagggacaga gacaaaattc agggcttcca      480

ggcaaaggga gaagctgata tcctggccgc gctgaagaag ctccaggacc agaggcagta      540

cattgtggct gagtttgagc agggtcatca gttcctgagg gagcgggagg aacacctgct      600

ggaacagctg gcgaagctgg agcaggagct cacggagggc agggagaagt tcaagagccg      660

gggcgtcggg gagcttgccc gg                                               682


<210> 2785
<211> 795
<212> DNA
<213> Homo sapiens

<400> 2785
cggcctgggc gtctcgagag gtgagagagt tggcggcgag gtctcggcgg ctaagcgagc       60

gtcggcgact gtctctccgc gagaggaggc aagttggggt ccaggctcca aagccggtgg      120

ccgcgtaccg cggtggagcc gctgtctttg aggtctgagg agagaacagt gatatcctga      180

gagaagatgg gaaagggctg caaggttgtg gtttgtggat tgttatctgt ggggaaaact      240

gcaattttgg agcagctcct ttatggaaat catactattg gaatggaaga ttgcgaaaca      300

atggaagatg tatacatggc ttcagtagaa acagaccgag gagtaaaaga acagttacat      360

ctttatgaca ccagaggtct acaggaaggc gtggagctgc caaagcatta tttttcattt      420

gctgatggct tcgttcttgt gtacagtgtg aataaccttg aatcctttca aagagtggag      480

cttctgaaga aagaaatcga taagttcaaa gacaaaaaag aggtagcaat tgtggtatta      540

ggaaacaaaa tcgacctttc tgagcagaga caagtggacg ctgaagtggc acagcagtgg      600

gcaaaaagtg agaaagtaag actgtgggag gtgactgtta cagatcggaa aactctgatt      660

gaaccattca ctttattagc cagtaaactt tctcaacccc agagcaaatc aagctttcct      720

ttgcctggga ggaaaaacaa agggaactct aattctgaga actaaaaatc agtaatttcc      780

acaattgtat gttga                                                       795


<210> 2786
<211> 370
<212> DNA
<213> Homo sapiens

<400> 2786
ttctcaagtt cctgccaatc ctcaatgcat aacagatctc aaggcttttt tttcagtagt       60

tgccaccccc aaaaccatgt ctcttatggc tgtcaatcac cgagctttat tttttgtcgc      120

tgtcaatcac tgaattttgt gtccaggacc tgctatccct tgagctattt ctcctatggt      180

aatcaaacta taggttctat atccaacagc ttcagatccc tgaattatgt gtctcatagt      240

ttccaaccta tttccttcat gcacagcagt ttccaaccag cttgttctga ttttgtgggt      300

tggcaatctc catttcttag aagaacatgc tgaattgtct tttcagtgtc ttgccctgac      360

agcgttttac                                                             370


<210> 2787
<211> 941
<212> DNA
<213> Homo sapiens

<400> 2787
aagccatcaa caccagagag ccagctgccg agatagaagc cttgctgggg atggatctgg       60

tcaggcttgg tttagaaaga ggggaaacag ctaaagaagc cttagatgtc attgtctcct      120

tgttggaaga acatggacaa ggtgggaatt actttgaaga tgcaaactcc tgccacagct      180

tccaaagtgc atatctgatt gtggatcgtg atgaagcctg ggtgctcgag accataggga      240

agtactgggc tgccgagaaa gtcacagaaa gcatcacagt gcagactatg atgaacacct      300

tacgggacaa agccagcgga gtgtgcatag actctgagtt tttcctcacc acagccagtg      360

gagtgtctgt cctgccgcag aatagaagct ctccgtgcat tcactacttc actggaaccc      420

ctgatccttc caggtccata ttcaagcctt tcatctttgt tgatgacgta aaacttgtcc      480

ccaaaacaca gtctccctgt tttggggatg acgaccctgc caaaaaggag cctcggttcc      540

aggagaaacc agaccgccgg catgagctgt acaaagccca cgagtgggca cgtgccatca      600

tcgaaagtga ccaggagcaa ggtcgcaagc tgaggagcac catgctggag ctggagaagc      660

aaggcctgga agccatggaa gaaatcctga ccagctccga gccactggac cctgcggaag      720

tgggggacct tttctatgac tgtgttgaca cggagattaa gttctttaag tgaagtaagc      780

gttccctttc cccttcttat ttaagacttc ccaccttact aaattaccag caaaacaaac      840

cactctcctg tttgagtaaa atgagaaagt taatatgtgg cctccttttc tgaagccaga      900

tcaaactgtt accttgtgtt ccaccttgaa tctcacagcg t                          941


<210> 2788
<211> 3938
<212> DNA
<213> Homo sapiens

<400> 2788
accgagaaga agatatttac cagtttgctt actgctaccc atatacatac actcgcttcc       60

aacattacct tgacagcctg caaaagagaa acatggatta cttctttcgg gagcagctgg      120

gccagagtgt gcaacaacga aagcttgacc tcctgacgat aaccagccct gacaatctcc      180

gggaaggggc agagcagaag gtggtattca tcacaggacg agtccaccca ggggaaacac      240

cctcatcatt tgtgtgccaa gggatcattg acttccttgt aagccagcac cctattgcct      300

gtgtcctccg ggaatacctg gtcttcaaga tcgcaccaat gctcaatcct gatggagtct      360

acctgggcaa ttacaggtgt tctctgatgg gatttgatct gaatcgtcac tggctggatc      420

cctctccatg ggtccatcct accctgcatg gagtgaaaca actcatcgtc cagatgtaca      480

acgacccaaa aacaagcctg gagttttata ttgacatcca tgcccactcc accatgatga      540

atggcttcat gtatggcaac atctttgagg atgaggaacg gttccagagg caggccattt      600

ttcccaagct cctctgccag aatgctgagg acttctccta ttccagcaca tcctttaacc      660

gggacgctgt gaaagcagga actggccgtc gcttcctcgg tggactcctg gaccacactt      720

cctattgcta caccctagag gtctccttct acagctacat catcagtggc accacggctg      780

ctgtgcccta cactgaagaa gcctgtatcc ttagtcccca cccagccttg ggccagccct      840

catccagccg agagtatcca agtctgacag gtcaggaatt aggcccccag ctcaggtaag      900

ggctgagact ctcaggtgag gatggaggtg cttcttcttc tggtggcgtc tttggattgt      960

ccagtttgcc tcagccctta gtatgatact cctaccccaa ttgccatgct ccaaatcttt     1020

cccaggccag ccggacccat ggcctgccca tatcttactc tgcttccatc tctctcccct     1080

ctcttctctc atgatgcagt gagtctcctg ccatctaagc tatgcaagtc cacaggctgg     1140

atgaccatcc ccagggttgc tgaggaagag cttgatgatc ttgactcctt ctaaccctga     1200

acatacaaaa acatatgttc tcttttcatc ttttgtctaa cctatcctct cccactttct     1260

cttccctcta ctcactattt ccccttctac ttacttttct cacccttgtt ccctctcctt     1320

ctatgccctc ctcctccctc ctcacctgtc ctgtgcttct ctttccttac ttctttttcc     1380

ccctcctccc ctcctttctg tcctctctct catcccatcc tccttttctt tctctcctct     1440

ttgcctgtct tctgtcttcc ttgtctttcc cctctcatcc tctgtgcatc tttctctctg     1500

cctttgcatt tcctttgaca aattcctttt cctcttagtt tcttcataaa atttctctga     1560

aaactccaaa gccttccatg atgaaattag aagttatttt ctagtttgcc taatttttta     1620

aggattaggt agtaactcta gtttcccgag tgttgatttt aatatcaagg tcactgcatc     1680

agagctgtaa cagatcgtgg cagattctgc tttccttgat cctttgtttt cgggttgatc     1740

tatgtctcct ttcctaacac ttagttttct cagagaagtg gagggaggag gaaggaactt     1800

tagatgaaat gaactctgta tttctgcaaa ttccccctcc ctggaggtag aagtgctctt     1860

ttagcatttt ttcaaccctt ggtgagtgtt tatggaattc ctctgtgcag gaaaacatct     1920

tttctgaacg tggcatgact tagggctagt cccaccagcc aactgcaact tagtggctct     1980

gtttgtatgt gtgtttggga gggttggggg tatggtgtcc aggtaccttg ccaggaacat     2040

cggaagtagg gcaatggccc tagaaggagg ggctgtcagg gggtaggcca ggtgttagag     2100

caatgttcca catcctgttg gacacagaga tattatgatt ggaactgaga gttccctatg     2160

tacagtcatc aagactgagg gtcatcttgc agtctgcttt aatacccacc tgactcagca     2220

aggccaaggg agtaggctct gctctgagga agagggtctg tgggttccaa agtcctggcc     2280

acctgttatg tgccacattg cccctcttca tgccccatac acaccttaga tgatgcatat     2340

ggcctatgcc ttctccagaa tctgctaact cctataacac atgcatatgc ttcattccac     2400

attgtacttg ctttgctctc ccataatatt atggcaaagg gacagagagc tgcctggaat     2460

aagagtttga gcttgtgcac taaaggggat tctgcaaccc ttattcatag tgagatgagg     2520

gtccctccag aggaggcctg cccttagttt gttgtttttt gctgtccaat ctgacaggct     2580

ctcctacctt ttcttagcac ttctgacatg cttctgtctt agaagaaaat gtgtttctta     2640

gtagaaagcc cacccttggt tcaggcccaa ggtttccacc cctcaacagc caacactcat     2700

ttatcaaaag taaacacagc attagtacat accaggaatc ataaaaggca cctagggtaa     2760

aatactgaat aaaaaggcat gattcctgac tcacagaact ttcagtctac ttggggagac     2820

agaaaaggga agagataatt acaatgtatg tgataaattc tggtggagga attccagaag     2880

gctctgggac attttcattt gacaagtata tattgagtgc ctgtcatagg tcaggtaaag     2940

ttctaggcac agggaatgta acagagaaca tactaaagac aagaatgtct ttacatgggg     3000

gaaagaggga actcacacgc agtcctagga gtcagggaag atttcccagg aaaagagaca     3060

tctaaactga gattttttgt ttgtttgttt ttgagatgga gtctcactct gttacccagg     3120

ctagagtgta gtggcatgat ctcagctcac tgcaacttct gcctcctggg ttcaagcgat     3180

tcccctgcct cagcctcctg agtagctggg attacaggtg tgcgccacca tgtccggcta     3240

atttttgtat ttttagcaga gatggggttt taccatgttg gtcaggctgg tctcaaactt     3300

ctgacctcgt gatccacctg cttcggcctc ccaaagtgct gagattacag gtgtaagcca     3360

ctgagcccgg cctaaactga gtttttaata tgaactagtc aaactgggtg agggtgttgt     3420

tgaagggagg atgtggtaga cagagagggg agtacagaag gtatgggcag aagctgtaag     3480

tggtccctta gggctgaagg acttcagact caatgataag tctgaagtgg aaagatgtaa     3540

gaagtttgat cttgaatgta gacaatggaa ggacagattc gagggggcca gtattgtaga     3600

cagggacatg cattaggagg ctgttataaa aatccaggtg agaaataatc caggccaaga     3660

ccagagtggt ggctgtagaa tacttagaat gtggaactga gaagacttgg taattgacta     3720

tttgggagtg gcgacaggga atgggagctc gtgattggaa ggggttaagg tgagtagaga     3780

ggctatgcac aagctgagca ggtcgtgata ctgatggacc taccctgcct tgttctgtcc     3840

tctagaggat gagaagagga aacaaactgc accagggaag ctcaggccga ttcaatgcat     3900

gcaagggtga tttaacctgg gttctgtttg aaatactt                             3938


<210> 2789
<211> 1728
<212> DNA
<213> Homo sapiens

<400> 2789
cgcgggggcc cgaccaccgc ggggccggga cgcgatggcg gcggcagagc ccgcgagctc       60

gggccagcag gcgccggcag ggcaggggca gggccagcgg ccgccgccgc agcctccgca      120

ggcgcaagcc ccgcagccgc ccccgccgcc gcagctcggg ggcgccgggg gcggcagcag      180

caggcacgag aagagcctgg ggctgctcac taccaagttc gtgtcgctgc tgcaggaggc      240

caaggacggc gttctggatc tcaaagcggc tgctgatact ttggctgtga ggcaaaaaag      300

gagaatttat gatatcacca atgtcttaga gggaattgac ttgattgaaa aaaagtcaaa      360

aaacagtatc cagtggaaag gtgtaggtgc tggctgtaat actaaagaag tcatagatag      420

attaagatat cttaaagctg aaattgaaga tctagaactg aaggaaagag aacttgatca      480

gcagaagttg tggctacagc aaagcatcaa aaatgtgatg gacgattcca ttaataatag      540

attttcctat gtaactcatg aagacatctg taattgcttt aatggtgata cacttttggc      600

cattcaggca ccttctggta cacaactgga ggtacccatt ccagaaatgg gtcagaatgg      660

acaaaagaaa taccagatca atctaaagag tcattcagga cctatccatg tgctgcttat      720

aaataaagag tcgagttcat ctaagcccgt ggtttttcct gttcccccac ctgatgacct      780

cacacagcct tcctcccagt ccttgactcc agtgactcca cagaaatcca gcatggcaac      840

tcaaaatctg cctgagcaac atgtctctga aagaagccag gctctgcagc agacatcagc      900

tacagatata tcttcagcag gatctattag tggagatatc attgatgagt taatgtcttc      960

tgacgtgttt cctctcttaa ggctttctcc taccccggca gatgactaca actttaattt     1020

agatgataac gaaggagttt gtgatctgtt tgatgtccag atactaaatt attagattcc     1080

atggaaactt gggactgtta tctacctcta actgtgtaac attttagact tcttaataac     1140

ctaaatattt aaaataatga atgtaacacc ttttttagtt cactgattct gaagtgttct     1200

tccctaatac tttctttact tcacaaaact tcaaccataa aaacaaaggg ctctgattgc     1260

tttaggggat aagtgattta atatccacaa acgtccccac tcccaaaagt aactatattc     1320

tggatttcaa cttttcttct aattgtgaat ccttctgttt tttcttctta aggaggaaag     1380

ttaaaggaca ctacaggtca tcaaaaacaa gttggccaag gactcattac ttgtcttata     1440

tttttactgc cactaaactg cctgtatttc tgtatgtcct tctatccaaa cagacgttca     1500

ctgccacttg taaagtgaag gatgtaaacg aggatatata actgtttcag tgaacagatt     1560

ttgtgaagtg ccttctgttt tagcacttta agtttatcac attttgttga cttctgacat     1620

tccactttcc taggttatag gaaagatctg tttatgtagt ttgtttttaa aatgtgccaa     1680

tgcctgtaca ttaacaagat ttttaaaaat aaaattgtat aaaacatt                  1728


<210> 2790
<211> 4128
<212> DNA
<213> Homo sapiens

<400> 2790
ttttatacca gttgcctcct catcttttac tgtctcgttc tttttctgca ggaccgttgt       60

ttgctctcaa cggcagttgc tggggctaac agaactggct gttgggagag agaggcgagg      120

caacgccgcc cggccctgcc attccatttt actgcttaac tcaacctgga gtgtcaggac      180

ctattctcct gcattctcgc tgcactatac gggggagcca agtcactctg tactcactgg      240

acagccaggc tgggtggaat agggttctag agtggagcag gggctctgcc ctttatggcg      300

actttctaaa agattagcat cagtgtcttt tgacagtata gcatctgggg tgggacgcgg      360

agaggaggct ttgcttgcta aacggcttct ttctccgccg gtgatctgga tttgtttcct      420

cggccccctc cccccgctcc tttctttctc ccctcccgcc tttagcaaag tgacacaggc      480

gacacctgct cgcttgtgtt cgatgttgga actcgcacct cctcggtggt gacggtgcca      540

gggcactgct accaggggga catcggcggg tttcccttcc ttccagccca cgatgcctag      600

aagggcagcg ggtgggctgc gtggggctct gcccgcagca cttcgaggcg ggattgaggg      660

gctgaagctg gccaggagtt gctgctaagt ggattcgagt ggaaggcgcc aagtctccgc      720

gagggcacca gcggggacct atctgcgagc agtgggaaca ggggcacctg gacggaggaa      780

cgcgggcgtc tggagggggg acatcggctg agctcagagc ctctcctcct tcctgtcccg      840

agcttcccag caactccgcc acgttggaga cccggtacct gcgagagcca gggaactcga      900

gaagtgcgtg gccgaggctg ctttcctgaa ggtgaatcat tctgtccaat tgcctttccc      960

cagagaacaa gagggagggc gggagagagg gaacggagga tgtgtgagtg tgtgtgtgtg     1020

tgagagggag agacgacgtg aggcgagagg aaaagtcttt agtcggcctt aaaagcaaac     1080

aaatcagaga tggaataaga gcggtaattg cagcaagacc gccttgattc ttgcagtcca     1140

gggagctgag cgcaccgcgc gcatccggcg aggacaggag gcgaccgcgg gcgctgccaa     1200

gggctgcggg actttggctt ttcctcagta aacaaatctt ttgattactt tgacactgtg     1260

gaataaagaa gcggggagaa ggatcaggct caccttcacc cgcttcaggg ggattccagc     1320

ttggatgtca gattcctgaa ccgtctttgc catcggagga ggaaacacat ccacacacgc     1380

gcgcgcacac tcgcacgctc agggccacac tcacacgccg ccctccacga tcacacagca     1440

ccagacttcg gttccctatg cccctggatg gtgacggcgg attggcatct tggaagcgat     1500

gcgagagcga taaggctggc gccggcccgc aaaagctgca ggagcatcgc taggtgttgc     1560

cgccaccggg aagcggggct gcaggatgag taagagatac ttacagaaag caacaaaagg     1620

aaaactgcta ataataatat ttattgtaac cttgtggggg aaagttgtat ccagtgcaaa     1680

ccatcataaa gctcaccatg ttaaaacggg aacttgtgag gtggtggcac tccacagatg     1740

ctgtaataag aacaagatag aagaacggtc acaaacagtc aagtgctcct gcttccctgg     1800

gcaggtggca ggcaccacgc gagctgctcc atcatgtgtg gatgcttcaa tagtggaaca     1860

gaaatggtgg tgccatatgc agccatgtct agagggagaa gaatgtaaag ttcttccgga     1920

tcggaaagga tggagctgtt cctctgggaa taaagtcaaa acaactaggg taacccatta     1980

acccaggaga aatcaagtga tcctcaaggc tgatgacatt gaacatgcgc atagaaactt     2040

aactcaactc ctgaggtgat cttgaagatt tttataccac ttgaaagagg cgctcaatag     2100

tctatttcca agggatttca tggcctcttc ttgaaatcaa gactttttaa aagtcagaca     2160

tgaacttgca tgtcatgaag atttcagcag atttgaactg tgttcaactt gtaaattgtt     2220

aaaagaattt gaagtcactg tctgaggagc tggtgaagag ttgttttttt cagggtgatg     2280

ttagagacag tcaccttttg agttattggc tccagatgtg actacttttc ttgtttctgc     2340

aagctgtatc ccaagtgcac tgtccttctg tcctggatgt gttcctgggt cctatgttca     2400

tttgctagtg ggactacaca tggctttaat gacatttcct ttgagaactt ttcctctggc     2460

atggtgtaga ctgagacaat tttatttata tcctaatctt ggagctcaga aagcctacat     2520

gttttaacat cttaaagttg cttttgttaa aggaatggaa atatatatcc attggtaata     2580

atgttggcaa gtaatagtta tctgaataaa tcaatcatat aagaatgtat agacaagctg     2640

acatatttcc ctaaggctaa caacaccctg ctgaagctct ttgtcaaata ggtagtagtt     2700

agaactggat tgccattttc attatataat actttgtacc tctagagcac tctccctttc     2760

tgtttttttt taagtgagct tttctttaat tttttatgtt tacttattcc cttcacagaa     2820

atcagcagtg agcagtcaag ttaatgggta gccttcagtt tcaaaaaaat tgacagggat     2880

gcatgtgagt ttctgatttc ttagcttgaa cattattcac ttagatttct tccagtattt     2940

tttaaaaaac tgtcctatct cattttaaaa gactttcttt tgcttgatcc caatgactgt     3000

ttgaatgctt atatatttgt tcaatctgtt gatagaaaaa attgttcatt ttcctcagtc     3060

tcaaatttat aaatatttgc ttacagtttt cctattcaaa caatttgtta ggccaatatt     3120

ttgtgacatt tttgtagcga ttttaacgtt tatggttttg gttctacagg aaagtcataa     3180

atatttaaag gccttaaaca tgtatgtact ttttttttct aagttataga atgtataatt     3240

ttgtactaca tttattttgt ttcatttgtg atatgaaggg agagaagaaa gaaaagtgca     3300

tagccattct gtaacaatat tgtgtaaacc tatagtttga aggaatgcaa ggagaaggat     3360

ttctgtgttt tactcatttt aggctgttca gaagatgctt caaaaattgt cctgttagaa     3420

tttccatcat ggaaggtggt atggaagaag gtatggaaat actttgtatt ctaaaaactc     3480

actgacgtgg tcagttagac atacgttggt ttccaggata gaggcccata tatcctgggg     3540

agctttggtc tattagtttg tgacaatatt caaaggccaa aacactactc agacactttc     3600

ctgggaagag caactaaaaa tgtaaaattg gttaaaaata aaatctgaaa agtatgtatc     3660

tcacattgaa ctaaaatcca ctgtctcata agttcatgga atgaaatggc tttctgcctc     3720

cattttaatc atgcataaaa tgaattagat ggctttgagt ggattttcac aatggctcaa     3780

gactatatga aattataaaa aaaaagttgc cctggggttt ctgcatcaat tagaatatca     3840

ttaatttctt tgtaaccaag tgaaaaacta tactttttgg aaattatgaa tttgtcctag     3900

gtttgtttga gatttgaaat tatacatcat gcttctcatt ttttaaacta tgttctttaa     3960

atcaacactg gaaactctgt attatataca agtgtaatac atgcatataa tagaaaaaaa     4020

acatggaatt tcaaatatac taactagatt atccccagta gattaatgtt gtgactattc     4080

agaaaaggtg aataaaattg ggatataaaa tggactctct ttcataaa                  4128


<210> 2791
<211> 744
<212> DNA
<213> Homo sapiens

<400> 2791
aaggtaactc tgggctacag agtccttgct gggggttcgg ggagcgcttg gaccccggct       60

tctgggacgc gtcaggtcgc cgtgaagatg attgcatgag atcgtgcgtg tgaacgtttg      120

ttgacagctg ttacttgagt ccgacagccc tgggggccgt gcatctgcgt aacatggcta      180

cctctgaact ccttggggga cacgtatatc tttgagaatc cgatgaaaac cagagattcc      240

gcccttgttt tcttagaatt aaaaatatta tccagcaatg caaatgaaca aactataact      300

acacacagct gcatggataa atgtcagaaa catgacgttg agtgtgagaa gccagatgca      360

aacgaggact cactgtgcaa ttctgtgcat gtacagtggc caggagaagg gagcactggc      420

tttgctttca tcaggccaaa gatgcctttc tttgggaata cgttcagtcc gaagaagaca      480

cctcctcgga agtcggcatc tctctccaac ctgcattctt tggatcgatc aacccgggag      540

gtggagctgg gcttggaata cggatccccg actatgaacc tggcagggca aagcctgaag      600

tttgaaaatg gccagtggat agcagagaca ggggttagtg gcggtgtgga ccggagggag      660

gttcagcgcc ttcgcaggcg gaaccagcag ttggaggaag agaacaatct cttgcggctg      720

aaagtggaca tcttattaga catg                                             744


<210> 2792
<211> 582
<212> DNA
<213> Homo sapiens

<400> 2792
agttacagtg gtggggacca ggagtaggga ggcagagact ggccccgtgc caggcctagc       60

actgcccaca ggcagggcga aggcgcggga gcagtttcca gcagttgtac aggtagccag      120

gtgtcggtct ccagcctgag aactctggct gttgttcctt gtgtcgtccc atattcctgc      180

ctggcctgcg atggacatca gcaagggcct cccaggcatg cagggaggcc tccacatatg      240

gatctctgag aaccggaaga tggtgccggt acccgagggg gcttacggga acttttttga      300

ggaacactgc tatgtcatcc tccacgtccc ccagagcccg aaggccacgc agggggcgtc      360

cagcgacctg cactactggg tcgggaagca ggcgggtgcg gaagcgcagg gcgctgcgga      420

ggccttccag cagcgcctac aggacgagct ggggggccag accgtgctgc accgcgaggc      480

gcagggccac gagtccgact gcttctgcag ctacttccgc ccgggaatca tctacaggaa      540

gggaggccta gcatctgacc tcaagcatgt ggagaccaac tt                         582


<210> 2793
<211> 223
<212> DNA
<213> Homo sapiens

<400> 2793
ggcctagatg ggaggatcac gacatcagga gaccgagacc atcctggcta acacgtgaaa       60

aatgccatgg ccttgtttct catagcaggt aaagaagaac caaagaattc actggtacta      120

acaattaaac ctatgccctc tgagatctca ttgggattcc ttaccccatc accatgtgca      180

cctcagaaac tttccaagcg ctggacacct tcgaagccag aca                        223


<210> 2794
<211> 6520
<212> DNA
<213> Homo sapiens

<400> 2794
attgtttgaa tttgaaaacg gtaacatcgc agtgctgctc gcgggtctgg ctagtcaggc       60

gaagtttgca gaatggaatc taattttaat caagagggag tacctcgacc atcttatgtt      120

tttagtgctg acccaattgc aaggccttca gaaataaatt tcgatggcat taagcttgat      180

ctgtctcatg aattttcctt agttgctcca aatactgagg caaacagttt cgaatctaaa      240

gattatctcc aggtttgtct tcgaataaga ccatttacac agtcagaaaa agaacttgag      300

tctgagggct gtgtgcatat tctggattca cagactgttg tgctgaaaga gcctcaatgc      360

atccttggtc ggttaagtga aaaaagctca gggcagatgg cacagaaatt cagtttttcc      420

aaggtttttg gcccagcaac tacacagaag gaattctttc agggttgcat tatgcaacca      480

gtaaaagacc tcttgaaagg acagagtcgt ctgattttta cttacgggct aaccaattca      540

ggaaaaacat atacatttca agggacagaa gaaaatattg gcattctgcc tcgaactttg      600

aatgtattat ttgatagtct tcaagaaaga ctgtatacaa agatgaacct taaaccacat      660

agatccagag aatacttaag gttatcatca gaacaagaga aagaagaaat tgctagcaaa      720

agtgcattgc ttcggcaaat taaagaggtt actgtgcata atgatagtga tgatactctt      780

tatggaagtt taactaactc tttgaatatc tcagagtttg aagaatccat aaaagattat      840

gaacaagcca acttgaatat ggctaatagt ataaaatttt ctgtgtgggt ttctttcttt      900

gaaatttaca atgaatatat ttatgactta tttgttcctg tatcatctaa attccaaaag      960

agaaagatgc tgcgcctttc ccaagacgta aagggctatt cttttataaa agatctacaa     1020

tggattcaag tatctgattc caaagaagcc tatagacttt taaaactagg aataaagcac     1080

cagagtgttg ccttcacaaa attgaataat gcttccagta gaagtcacag catattcact     1140

gttaaaatat tacagattga agattctgaa atgtctcgtg taattcgagt cagtgaatta     1200

tctttatgtg atcttgctgg ttcagaacga actatgaaga cacagaatga aggtgaaagg     1260

ttaagagaga ctgggaatat caacacttct ttattgactc tgggaaagtg tattaacgtc     1320

ttgaagaata gtgaaaagtc aaagtttcaa cagcatgtgc ctttccggga aagtaaactg     1380

actcactatt ttcaaagttt ttttaatggt aaagggaaaa tttgtatgat tgtcaatatc     1440

agccaatgtt atttagccta tgatgaaaca ctcaatgtat tgaagttctc cgccattgca     1500

caaaaagttt gtgtcccaga cactttaaat tcctctcaag agaaattatt tggacctgtc     1560

aaatcttctc aagatgtatc actagacagt aattcaaaca gtaaaatatt aaatgtaaaa     1620

agagccacca tttcatggga aaatagtcta gaagatttga tggaagacga ggatttggtt     1680

gaggagctag aaaacgctga agaaactcaa aatgtggaaa ctaaacttct tgatgaagat     1740

ctagataaaa cattagagga aaataaggct ttcattagcc acgaggagaa aagaaaactg     1800

ttggacttaa tagaagactt gaaaaaaaaa ctgataaatg aaaaaaagga aaaattaacc     1860

ttggaattta aaattcgaga agaagttaca caggagttta ctcagtattg ggctcaacgg     1920

gaagctgact ttaaggagac tctgcttcaa gaacgagaga tattagaaga aaatgctgaa     1980

cgtcgtttgg ctatcttcaa ggatttggtt ggtaaatgtg acactcgaga agaagcagcg     2040

aaagacattt gtgccacaaa agttgaaact gaagaaacac ataattatgt aggatttgaa     2100

gatattattg attctcttca agataatgtt gctgatatta agaaacaggc tgaaattgct     2160

cacttatata ttgcatctct tcctgacccc caggaagcta ctgcttgttt agaactaaag     2220

tttaatcaaa ttaaagctga attagctaaa accaaaggag aattaatcaa aaccaaagaa     2280

gagttaaaaa agagagaaaa tgaatcagat tcattgattc aagagcttga gacatctaat     2340

aagaaaataa ttacacagaa tcaaagaatt aaagaattga taaatataat tgatcaaaaa     2400

gaagatacta tcaacgaatt tcagaaccta aagtctcata tggaaaacac atttaaatgc     2460

aatgacaagg ctgatacatc ttctttaata ataaacaata aattgatttg taatgaaaca     2520

gttgaagtac ctaaggacag caaatctaaa atctgttcag aaagaaaaag agtaaatgaa     2580

aatgaacttc agcaagatga accaccagca aagaaaggta ctacttcagc tgccagcagc     2640

aggcgtttaa gaaagctaat ttctaaacca gtaaatagaa caaggcaaac agaggggcat     2700

tcacttgtgt ctatccatgt tagttcagct atcactgaag accaaaagaa aagtgaagaa     2760

gtgcgaccga acattgcaga aattgaagac atcagagttt tacaagaaaa taatgaagga     2820

ctgagagcat ttttactcac tattgagaat gaacttaaaa atgaaaagga agaaaaagca     2880

gaattaaata aacagattgt tcattttcag caggaacttt ctctttctga aaaaaagaat     2940

ttaactttaa gtaaagaggt ccaacaaatt cagtcaaatt atgatattgc aattgctgaa     3000

ttacatgtgc agaaaagtaa aaatcaagaa caggaggaaa agatcatgaa attgtcaaat     3060

gagatagaaa ctgctacaag aagcattaca aataatgttt cacaaataaa attaatgcac     3120

acgaaaatag acgaactacg tactcttgat tcagtttctc agatttcaaa catagatttg     3180

ctcaatctca gggatctgtc aaatggttct gaggaggata atttgccaaa tacacagtta     3240

gaccttttag gtaatgatta tttggtaagt aagcaagtta aagaatatcg aattcaagaa     3300

cccaataggg aaaattcttt ccactctagt attgaagcta tttgggaaga atgtaaagag     3360

attgtgaagg cctcttccaa aaaaagtcat cagattgagg aactggaaca acaaattgaa     3420

aaattgcagg cagaagtaaa aggctataag gatgaaaaca atagactaaa ggagaaggag     3480

cataaaaacc aagatgacct actaaaagaa aaagaaactc ttatacagca gctgaaagaa     3540

gaattgcaag aaaaaaatgt tactcttgat gttcaaatac agcatgtagt tgaaggaaag     3600

agagcgcttt cagaacttac acaaggtgtt acttgctata aggcaaaaat aaaggaactt     3660

gaaacaattt tagagactca gaaagttgaa tgtagtcatt cagccaagtt agaacaagac     3720

attttggaaa aggaatctat catcttaaag ctagaaagaa atttgaagga atttcaagaa     3780

catcttcagg attctgtcaa aaacaccaaa gatttaaatg taaaggaact caagctgaaa     3840

gaagaaatca cacagttaac aaataatttg caagatatga aacatttact tcaattaaaa     3900

gaagaagaag aagaaaccaa caggcaagaa acagaaaaat tgaaagagga actctctgca     3960

agctctgctc gtacccagaa tctgaaagca gatcttcaga ggaaggaaga agattatgct     4020

gacctgaaag agaaactgac tgatgccaaa aagcagatta agcaagtaca gaaagaggta     4080

tctgtaatgc gtgatgagga taaattactg aggattaaaa ttaatgaact ggagaaaaag     4140

aaaaaccagt gttctcagga attagatatg aaacagcgaa ccattcagca actcaaggag     4200

cagttaaata atcagaaagt ggaagaagct atacaacagt atgagagagc atgcaaagat     4260

ctaaatgtta aagagaaaat aattgaagac atgcgaatga cactagaaga acaggaacaa     4320

actcaggtag aacaggatca agtgcttgag gctaaattag aggaagttga aaggctggcc     4380

acagaattgg aaaaatggaa ggaaaaatgc aatgatttgg aaaccaaaaa caatcaaagg     4440

tcaaataaag aacatgagaa caacacagat gtgcttggaa agctcactaa tcttcaagat     4500

gagttacagg agtctgaaca gaaatataat gctgatagaa agaaatggtt agaagaaaaa     4560

atgatgctta tcactcaagc gaaagaagca gagaatatac gaaataaaga gatgaaaaaa     4620

tatgctgagg acagggagcg tttttttaag caacagaatg aaatggaaat actgacagcc     4680

cagctgacag agaaagatag tgaccttcaa aagtggcgag aagaacgaga tcaactggtt     4740

gcagctttag aaatacagct aaaagcactg atatccagta atgtacagaa agataatgaa     4800

attgaacaac taaaaaggat catatcagag acttctaaaa tagaaacaca aatcatggat     4860

atcaagccca aacgtattag ttcagcagat cctgacaaac ttcaaactga acctctatcg     4920

acaagttttg aaatttccag aaataaaata gaggatggat ctgtagtcct tgactcttgt     4980

gaagtgtcaa cagaaaatga tcaaagcact cgatttccaa aacctgagtt agagattcaa     5040

tttacacctt tacagccaaa caaaatggca gtgaaacacc ctggttgtac cacaccagtg     5100

acagttaaga ttcccaaggc tcggaagagg aagagtaatg aaatggagga ggacttggtg     5160

aaatgtgaaa ataagaagaa tgctacaccc agaactaatt tgaaatttcc tatttcagat     5220

gatagaaatt cttctgtcaa aaaggaacaa aaggttgcca tacgtccatc atctaagaaa     5280

acatattctt tacggagtca ggcatccata attggtgtaa acctggccac taagaaaaaa     5340

gaaggaacac tacagaaatt tggagacttc ttacaacatt ctccctcaat tcttcaatca     5400

aaagcaaaga agataattga aacaatgagc tcttcaaagc tctcaaatgt agaagcaagt     5460

aaagaaaatg tgtctcaacc aaaacgagcc aaacggaaat tatacacaag tgaaatttca     5520

tctcctattg atatatcagg ccaagtgatt ttaatggacc agaaaatgaa ggagagtgat     5580

caccagatta tcaaacgacg acttcgaaca aaaacagcca aataaatcac ttatggaaat     5640

gtttaatata aattttatag tcatagtcat tggaacttgc atcctgtatt gtaaatataa     5700

atgtatatat tatgcattaa atcactctgc atatagattg ctgttttata catagtataa     5760

ttttaattca ataaatgagt caaaatttgt atatttttat aaggcttttt tataatagct     5820

tctttcaaac tgtatttccc tattatctca gacattggat cagtgaagat cctaggaaag     5880

aggctgttat tctcatttat tttgctatac aggatgtaat aggtcaggta tttggtttac     5940

ttatatttaa caatgtctta tgaatttttt ttactttatc tgttatacaa ctgattttac     6000

atatctgttt ggattatagc taggatttgg agaataagtg tgtacagatc acaaaacatg     6060

tatatacatt atttagaaaa gatctcaagt ctttaattag aatgtctcac ttattttgta     6120

aacattttgt gggtacatag tacatgtata tatttacggg gtatgtgaga tgttttgaca     6180

caggcatgca atgtgaaata cgtgtatcat ggagaatgag gtatccatcc cctcaagcat     6240

ttttcctttg aattacagat aatccaatta cattctttag atcatttaaa aatatacaag     6300

taagttatta ttgattatag tcactctatt gtgctatcag atagtagatc attcttttta     6360

tcttatttgt ttttgtaccc attaaccatc cccacctccc cctgcaaccg tcagtaccct     6420

taccagccac tggtaaccat tcttctactc tgtatgccca tgaggtcaat tgattttatt     6480

tttagatccc ataaataaat gagaacatgc agtctttgtc                           6520


<210> 2795
<211> 2398
<212> DNA
<213> Homo sapiens

<400> 2795
atgcgctgtc ccaaatccgc tgttactatg agaaatgaag agctgctttt aagtaacggc       60

acagccaaca agatgaacgg agctttggat cactcagacc aaccagaccc agatgccatt      120

aagatgtttg tcggacagat cccccggtca tggtcggaaa aggagctgaa agaacttttt      180

gagccttacg gagccgtcta ccagatcaac gtcctccggg accggagtca gaaccctccg      240

cagagtaaag gttgttgttt cgtaacattt tatacaagaa aagctgcact tgaggcccag      300

aatgcactgc acaatattaa aactttacct gggatgcatc atcccattca gatgaaacct      360

gcagatagtg aaaagtccaa cgctgtggaa gacagaaaat tgttcatagg aatggtatcg      420

aagaaatgta atgagaacga catcagggtg atgttctctc catttggcca gatagaagaa      480

tgccggatcc tccggggacc tgatgggctg agtcgaggct gtgcgtttgt cacattttct      540

acaagggcaa tggcacagaa tgcaatcaaa gccatgcatc agtctcagac catggagggc      600

tgctcttcac ctatcgtggt gaagtttgct gacactcaga aggacaaaga gcaaaggcgc      660

ctccagcagc agctcgctca gcagatgcag cagctcaaca ctgccacctg ggggaacctg      720

acagggctgg gcggactgac cccacagtat ctggcgctcc tgcagcaggc cacctcctcc      780

agcaacctgg gtgcgttcag cggcattcaa caaatggcag gcatgaatgc tttacagttg      840

cagaacctgg cgacgctggc tgctgctgca gctgcggccc agacctcagc caccagcacc      900

aatgcaaacc ctctctctac cacgagcagc gccctgggag ccctcacgag tcccgtggct      960

gcttcaaccc ccaactccac tgctggtgca gccatgaact ccttgacctc tctcgggact     1020

ctgcaaggac tggctggagc cactgttgga ctgaataata ttaatgcact agcaggtatg     1080

gcggctctga atggaggact tggcgccaca ggcttgacga atggcacggc tggcaccatg     1140

gacgccctca cccaggccta ctcaggaatt caacagtacg cagccgccgc gctgcccact     1200

ctgtacagcc agagcctgct gcagcagcag agcgctgcag gcagccagaa ggaaggtcca     1260

gagggggcaa acctctttat ttaccacctt ccacaggaat ttggagacca ggacattctg     1320

cagatgttca tgccttttgg aaatgttatc tctgctaaag tcttcattga caaacagacc     1380

aatctgagca agtgctttgg ttttgttagc tacgacaatc cagtctctgc acaagctgct     1440

atccaagcta tgaatggctt tcagatcggc atgaaacgct tgaaggtgca gctgaagcgt     1500

tccaaaaacg acagcaaacc ttactgatcc taaccccaga ggctccctgc tctcatttta     1560

gctttcttag gacatcttca tgcccgttag ttcatcgttt gcctagcatg tccctgtggc     1620

gtctcaaaaa aaagtttcat cgtcccgtca ttgtttctga tgtctttctg acctcacatc     1680

atatttggtt ctcctactga cctttgatct agtttgacct ttgaaatttg catgtgacct     1740

catctagcta tgaattctgg gaagtcaatg tgaaaaacat tgctgcattc atgcaagact     1800

gaaatttatt attagacaaa ttcattatag aaaaaacctg tggcaaaaac gtttctttct     1860

tatttttttt cttttcctaa aacagacttg aaagtattat acagggattg gcattcttcc     1920

cggtcactgg taacaatagc aatatgtgtc cagggacaca gaatgttggt ttctaacaga     1980

ctacttccaa aaacagtttg agaaaaaaac tgtctgattt taagtctcta gaggtctgta     2040

atagttttta catttttcag gcagtgtaaa gttttttgat aaggccattt taggtggctc     2100

actttctcat taagatatat atatagaacc actttttgta gattagtata agaaaaatat     2160

ttaccctgtt ttggggcaaa tgctacctat ttgtgtcacc ttttgctgaa ctcacagtta     2220

gacaatccat ggtttaatgc acatgaaatt acctatattt tatactgttt caatgtacag     2280

gagaaaggtt actgtaaact gtgttatgtt ggtgcttctg tgaattaagt tgtggtttca     2340

tcatgagtct taatgttctt tgttgataag acaagtttag aattggttta cttaatac       2398


<210> 2796
<211> 1714
<212> DNA
<213> Homo sapiens

<400> 2796
agagccagag agaacttcca gcgcaaaagg aaaataaaac ttgtggctgg tgtttgtgca       60

ggagggtctc cgccatcctg aagccccccg atcctggggc gtctcggggg ccgccaaagg      120

agcgccaggg ttaaaatgtt tatcggtgga ctgagctggc agacctcacc agatagcctt      180

agagactatt ttagcaaatt tggagaaatt agagaatgta tggtcatgag agatcccact      240

acgaaacgct ccagaggctt cggtttcgtc acgttcgcag acccagcaag tgtagataaa      300

gtattaggtc agccccacca tgagttagat tccaagacga ttgaccccaa agttgcattt      360

cctcgtcgag cgcaacccaa gatggtcaca agaacaaaga aaatatttgt aggcgggtta      420

tctgcgaaca cagtagtgga agatgtaaag caatatttcg agcagtttgg caaggtggaa      480

gatgcaatgc tgatgtttga taaaactacc aacaggcaca gagggtttgg ctttgtcact      540

tttgagaatg aagatgttgt ggagaaagtc tgtgagattc atttccatga aatcaataat      600

aaaatggtag aatgtaagaa agctcagccg aaagaagtca tgttcccacc tgggacaaga      660

ggccgggccc ggggactgcc ttacaccatg gacgcgttca tgcttggcat ggggatgctg      720

ggatatccca acttcgtggc gacctatggc cgtggctacc ccggatttgc tccaagctat      780

ggctatcagt tcccaggctt cccagcagcg gcttatggac cagtggcagc agcggcggtg      840

gcggcagcaa gaggatcagt cctgaatagc tacagtgctc aaccgaattt tggcgcgccc      900

gcttccccgg caggctccaa cccggcgcgg cccggaggct tcccgggggc caacagccca      960

ggacctgtcg ccgatctcta cggccctgcc agccaggact ccggagtggg gaattacata     1020

agtgcggcca gcccacagcc gggctcgggc ttcggccacg gcatagctgg acctttgatt     1080

gcaacggcct ttacaaatgg ataccattga gcaggtgctt tcgttgccat ctcactctga     1140

gagcatacct ggatgtccag gcaagactgg gcgaagtttc tgagtggccc tttgtttagg     1200

tgatgtcctc agacctggac ccccaccagc ctcactcccc atcccaacca gagatggctc     1260

acttcggatc gagggttgac tacatctcat catctcacga atctgctgta atataagaca     1320

acagctttta aatgtgtata taacccatga tttcggtttt gttttgtttt gtttttcttg     1380

atggtttccc tctccctccc tctcttccca ttctcctttt aaatctcttt gaatcacatt     1440

tggtagtgat tttgacttag tccagtagtc acatagcttt aatatctagt tcaaagctaa     1500

ccatagtata attgttatat taaggagtta ttttttctta aaacattttt ttttgcttgt     1560

tttggttctg ttctcacttt taaaggatgc tgagatggta atatgactct ccatattttg     1620

gtaccaattc tgagactgta tgaattttca ggtggaactt tagcacacac tgaagcaaag     1680

ttgtgaagtg cagggcggga ggtgggcgtg agct                                 1714


<210> 2797
<211> 430
<212> DNA
<213> Homo sapiens

<400> 2797
ccacaagcca tgctatgggg ctctctttgg acccaggggg gtgaacattg gtggtgtagg       60

ctcctacttg tacaatcccc ccactcccag ccctggctgc accactcctc tcagccccag      120

cagcttcagc cctcccaggc caaggactgg cctcccccaa ggcaagaaaa ctgagaaggt      180

gatgtcatta ggcagaaatt ggcaccgacc gtgtctgagg tgccagcgtt gccacaagac      240

cctgactgct gggagtcatg ctgagcatga tggagtcccc tactgccacg tcccctgcta      300

cggctacctg tttggcccca aagccctcta ggtcctgcct gtttcttgcc tgcctcaccc      360

agtggcatca cgatgatggt aaaaccagcc agggctgagc cagtaagggt gcgggtgatg      420

gcaaacatta                                                             430


<210> 2798
<211> 714
<212> DNA
<213> Homo sapiens

<400> 2798
caacagggac cgaccaaatc gtcatgcagc tgtttggatg ctttaaaaaa ataaatcccc       60

acactcatta cgcgttttat gctgctgact tttttatttt taagacatct gctcccgaaa      120

gctcagagcc ctttagcatt tcattttcta aacgaatcct aatctttcct gtgactgaat      180

cggttcagag gatatctttt caataaggaa ggaagccctc ccctgctcac tggggacgtc      240

gcagggtttt taaacctaaa gatttactct tttgtgcaca gacgctggaa gcatttggaa      300

tgaaatatga ctgaggactc tcagagaaac tttcgttcag tatattatga gaaagtgggg      360

tttcgtggag ttgaagaaaa gaaatcatta gaaattctcc taaaagatga ccgtctggat      420

actgagaaac tttgtacttt tagtcagagg ttccctctcc cgtccatgta ccgtgcattg      480

gtatggaagg tgcttctagg aatcttgcct ccacaccacg agtcccatgc caaggtgatg      540

atgtatcgta aggagcagta cttggatgtc cttcatgccc tgaaagtcgt tcgctttgtt      600

agtgatgcca cacctcaggc tgaagtctat ctccgcatgt atcagctgga gtctgggaag      660

ttacctcgaa gtccctcttt tccactggag ccagatgatg aagtgtttct tgcc            714


<210> 2799
<211> 1911
<212> DNA
<213> Homo sapiens

<400> 2799
agtgctccgg gcgcttcagg ctggcttggg tcctgctgct ccaaccccaa gggccctgga       60

gcgctccctg atacctccat cactcaccat ggccagccag ttctgcctcc ctgaatcccc      120

atgtctctcg cccccgccct tatccccctt ggctctggcg ccctcttcgg ccatcaggga      180

ccagcgtacc gccacgaaat gggttgcgat gatcccccag aaaaaccaaa cagcctcagg      240

ggacagcctg gatgtgaggg tccccagcaa accttgtctg atgaagcaga aaaagtctcc      300

ctgcctctgg gaaatccaga aactgcagga gcagcgggaa aagcgcaggc ggctgcagca      360

ggagatccga gctagacgcg ccctcgatgt caataccaga aaccccaact acgaaatcat      420

gcacatgatc gaagagtatc gcaggcacct ggacagcagc aagatctcag tcctggagcc      480

cccgcaagaa catcgcatct gcgtctgcgt gaggaagcgg cctctcaacc agcgagagac      540

aaccttaaag gaccatgcct tcgatgacaa agcctccaac gagttggtgt accagttcac      600

cgcccagcca ctggtggagt ccatcttccg caagggcatg gccacctgct ttgcctatgg      660

gcagacggga agtgggaaga cgtacaccat gggtggagac ttttcaggaa cggcccaaga      720

ttgttctaag ggcatttatg ctctggtggc acaggatgtc tttctcctgc tcagaaactc      780

cacatatgag aagctggacc tcaaagtcta tgggacattt tttgagattt atgggggcaa      840

ggtgtatgat ttgttgaact ggaagaagaa gctgcaagtc cttgaggatg gcaatcagca      900

aatccaagtg gtcgggctgc aggagaaaga ggtgtgttgt gtggaggaag tgctgaacct      960

ggtggaaata gggaatagct gtcggacttc caggcaaaca cctgtcaacg ctcactcatc     1020

caggagccat gcagtgttcc agatcatcct gaagtcagga cggataatgc atggcaagtt     1080

ttccctcgtt gatttagctg ggaatgaaag aggagcagat acaaccaagg ccagccggaa     1140

aaggcagctg gaaggggcag agattaacaa gagtcttcta gccctcaaag aatgtattct     1200

ggctttgggt cagaacaagc ctcacacccc attcagagcc agcaaactca cactggtgct     1260

ccgggactcc tttataggcc agaactcctc cacttgcatg attgctacca tctctccggg     1320

gatgacctct tgtgaaaaca ctctcaacac tttaagatat gcaaacagag taaaaaaatt     1380

aaatgtagat gtaaggccct accatcgtgg ccactatccg attggacatg aggcaccaag     1440

gatgttaaaa agtcacatcg gaaattcaga aatgtccctt cagagggatg aatttattaa     1500

aataccttat gtacagagtg aggagcagaa agagattgaa gaggttgaaa cattacccac     1560

tctgttaggg aaggatacca caatttcagg gaagggatct agccaatggc tggaaaacat     1620

ccaggagaga gctggtggag tacaccatga tattgatttt tgcattgccc ggtctttgtc     1680

cattttggag cagaaaattg atgctctgac cgagatccaa aagaaactga aattattact     1740

agctgacctc cacgtgaaga gcaaggtaga gtgaagccaa tggcgagaga tcaggtccga     1800

aatgctgcat tgctgcagtt tccaccactc ttatacagga aaactgtcca aattatctaa     1860

agatcctcct gagaagctta aaacatctta aaatacactg atgggaaaca t              1911


<210> 2800
<211> 394
<212> DNA
<213> Homo sapiens

<400> 2800
tgtcagcttg cattgggaac tgctctacag ccttagaaga gctgacagat gacatgacag       60

aagacttcct acctgtgctc agggaatata ttttatactc tgactccatg aagagtgtat      120

tgaagaagag ggaccaagtt caagcagagt atgaagccaa actggaagct gtggctctgc      180

ggaaggaaga ccgccccaag gtaccggcgg acgtcgagaa atgtcaggat cggatggagt      240

gtttcaatgc tgacctgaaa gctgacatgg agaggtggca gaacaacaag aggcaggact      300

tccggcagct actcatgggg atggctgaca agaacatcca gtattatgag aagtccattg      360

cagatctgaa gtgatggcct agggagagag cagg                                  394


<210> 2801
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 2801
acggggcggg gacgagctgt cgcgctggtt gctcgtgcag gagcgggacc cggaacagac       60

cgccgtgaga gaggaggggt gccggccggg attcgcggcc cggagctcgg gaccggagtc      120

aggaatggag agaagggtaa tggttttacc tcttattgtg gaaacctgtt gagatcacag      180

agaatatact gacggcataa aagggcagaa ccatagcagg gtgcggttgc ttcattccag      240

cctcgcagtc acctctgtgc cctgctggtt gtcttcccag cgctgctgta gttgccttcc      300

atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg aacggagacc      360

tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg aagaggaggt      420

gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact gtggccacgt      480

cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc ccgtctgccc      540

actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac tggccagcct      600

ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag aggtgacccg      660

ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact actactgtga      720

ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca ggccccacac      780

ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga accacctgag      840

taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag aagctgatat      900

cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg agtttgagca      960

gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg cgaagctgga     1020

gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg agcttgcccg     1080

gctggccctg gtcatctccg aactggaggg caaggcgcag cagc                      1124


<210> 2802
<211> 1415
<212> DNA
<213> Homo sapiens

<400> 2802
gggccggggg ctgccggctg cgctcgggcc gtgcgcggcg gccgtgcggg cacgccatgg       60

acttcaacat gaagaagctg gcgtcggacg cgggcatctt cttcacccgg gcggtgcagt      120

tcacggagga gaaatttggc caggctgaga agactgagct tgatgcccac tttgaaaacc      180

ttctggcccg ggcagacagc accaagaact ggacagagaa gatcttgagg cagacagagg      240

tgctgctgca gcccaacccc agtgcccgag tggaggagtt cctgtatgag aagctggaca      300

ggaaggtccc ctcaagggtc accaacgggg agctgctggc tcagtacatg gcagacgcgg      360

ccagtgagct ggggccgacc accccctatg ggaagacact gatcaaggtg gcagaagctg      420

aaaagcaact gggagccgcg gagagggatt ttatccacac ggcctccatc agcttcctca      480

cacccttgcg caacttcctg gagggggact ggaagaccat ctcgaaggag aggcggctcc      540

tccaaaaccg gcgtctggac ttggatgcct gcaaagcgag gctgaagaag gccaaggctg      600

cagaagccaa agccacgctc tggaatgatg aagtggacaa ggccgagcag gagctccgcg      660

tggcccagac agagtttgac cggcaagcag aagtgacccg tctcttgctg gagggaatca      720

gtagcactca cgtgaaccac ctgcgctgcc tccacgagtt cgtcaagtct cagacaacct      780

actacgcaca gtgctaccgc cacatgctgg acttgcagaa gcagctgggc agatttcccg      840

gcaccttcgt gggcaccaca gagcccgcct ccccacccct gagcagcacc tcacccacca      900

ctgctgcggc cactatgcct gtggtgccct ctgtggccag cctggcccct ccgggggagg      960

cctcgctctg cctggaagag gtggcccccc ctgccagtgg gacccgcaaa gctcgggtgc     1020

tctatgacta cgaggcagcc gacagcagtg agctggccct gctggctgat gagctcatca     1080

ctgtctacag cctgcctggc atggaccctg actggctcat tggcgagaga ggcaacaaga     1140

agggcaaggt ccctgtcacc tacttggaac tgctcagcta ggcaggtgcc cccatccccc     1200

ccgcattctg gcctaggcag gagaggatgg gcgcagccct gccacttaac ttgtttgttg     1260

gtgacacagt tgttcagagt ggggagaatt caccccattc tgtccctgcc cctagtcacc     1320

tagctgtgag ggtgcctgag gctgaatggc tccacccctc ccccagccct gcttctgacc     1380

tgtggctctg gagcccctgc ccctgcctgc atccc                                1415


<210> 2803
<211> 3009
<212> DNA
<213> Homo sapiens

<400> 2803
agtgtgtgac ccagcccttc ccccgtggcc aagcagagag agtggccttg aggaagccat       60

agcagcagga ccagcatggc ctctgctgcc tctgtgacca gcctggcaga tgaagtcaac      120

tgccccatct gtcagggtac cctgagggag ccggtcacta tcgactgcgg ccacaacttc      180

tgccgggcct gccttacccg ctactgtgag ataccaggcc cagacctgga ggagtcccct      240

acttgcccac tctgcaaaga acccttccgt cctgggagct tccggcccaa ctggcagctg      300

gctaacgtgg tggagaacat tgagcgcctc cagctggtgt ccacactggg tttgggagag      360

gaggatgtct gccaagagca cggagagaag atctacttct tctgtgagga tgatgagatg      420

cagttgtgcg tggtgtgccg ggaggctggg gagcacgcta cccacaccat gcgcttcctg      480

gaggatgcag cggctcccta tagggaacaa atccataagt gtcttaaatg tctaagaaaa      540

gagagagagg agattcaaga aatccagtca agagaaaata aaaggatgca agtcctcctg      600

actcaggtgt ccaccaagag acaacaggtg atttctgagt tcgcacacct gaggaagttt      660

ctagaggaac agcagagcat cctcttagca caattggaga gccaggatgg ggacatcttg      720

aggcaacggg atgaatttga tttgctggtt gctggggaga tctgccggtt tagtgctctt      780

attgaagaac tggaggagaa gaatgagagg ccagcaaggg agctcctgac ggacatcaga      840

agcactctaa taagatgtga aaccagaaag tgccggaaac cggtggctgt gtcgccagag      900

ctgggccaga ggattcggga ctttccccag caggccctcc cgctgcagag ggagatgaag      960

atgtttctgg aaaaactatg ctttgagttg gactatgagc cagctcacat ttctctagac     1020

cctcagactt cccaccccaa gctcctcttg tccgaggacc accagcgagc tcagttctcc     1080

tacaaatggc agaactcacc agacaacccc cagcgttttg accgggccac ctgtgttctg     1140

gcccacactg gcatcacagg ggggagacac acgtgggtgt ggatggccag ggtacctggg     1200

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1260

tagaaagagc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1320

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1380

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1440

agtgtggtgg ccactggtga cttgaaaatg tagagaaaaa aaaaacctgc tctatatctg     1500

aaagagctct tgggaagaca gagaaacata aagaggaaat tatagcacag tgtggtgggt     1560

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     1620

ggaaggagag gatgagtggg ggatggcttt ctgaaaaggg tagtctaaag gatgcctata     1680

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     1740

ggatgacctg tgactctgga gcactgggtt gtctccattg tccttatggg cagatgtgtg     1800

ccatccccag ccgacaccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     1860

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     1920

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     1980

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2040

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaccttta     2100

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2160

ggaagagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2220

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gatgtaaaat     2280

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2340

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2400

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     2460

aagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     2520

aaaatacaga cacacacaag tgcctatata atgataaaac atatgcaaag cacccaaacc     2580

tgtgattcca gaaaggtaga tcctattttt ctgtttattt ttattggctt tagctgtgtc     2640

ttttgaaagg actattatcc tctaaaatgt atgtgtatga agatcctggc ttgcagctcg     2700

ggagctttac acaccttgtg tcactttatc ttggtaacga gccaagatca tgcaaccagt     2760

tcatccatgt ctgacccaag agctcttaac tgctatgctg cactgcctca ttcagagata     2820

gatgcctgca tgggtcctgg cgattatttt aatgctggct acacccccac aggtgacttg     2880

gattcagaaa tacaatttat atttcttctt tttaaattgt tttattttat ttttctttta     2940

atagttatat gtcagtgaga acaatttata tgtcttacac tgagaaataa aactgctcat     3000

aagtgaaaa                                                             3009


<210> 2804
<211> 1254
<212> DNA
<213> Homo sapiens

<400> 2804
agaaagctgt ggaggtgtgc cccagcacgg ctgctttgaa aggtttatca tctatccgtt       60

tggtttatgg agaaaaagaa aatggtaact cagggtaacc aggagccgac aacaactcct      120

gacgcaatgg ttcagccttt tactaccatc ccatttccac cacctccgca gaatggaatt      180

cccacagagt atggggtgcc acacactcaa gactatgccg gccagaccgg tgagcataac      240

ctgacactct acggaagtac gcaagcccac ggggagcaga gcagcaactc acccagcaca      300

caaaatggat ctcttacgac agaaggtgga gcacagacag acggccagca gtcacagaca      360

caaagtagtg aaaattcaga gagtaaatct accccgaaac ggctgcatgt ctctaatatt      420

cctttccgct tccgggaccc tgacctccgg cagatgtttg ggcagtttgg caaaatccta      480

gatgtagaaa taatctttaa tgaacgtggc tctaagggat tcgggttcgt aactttcgag      540

aatagtgctg atgcagacag ggccagggag aaattacacg gcaccgtggt agagggccgt      600

aaaatcgagg tgaataatgc tacagcacgt gtaatgacca ataagaagat ggtcacacca      660

tatgcaaatg gttggaaatt aagcccagta gttggagctg tatatggtcc ggagttatat      720

gcagcatcca gctttcaagc agatgtgtcc ctaggcaatg atgcagcagt gcccctatca      780

ggaagagggg gtatcaacac ttacattcct ttaatcattc ctggcttccc ttaccctact      840

gcagccacca cggcagccgc tttcagagga gcccatttga ggggcagagg gcggacagta      900

tatggtgcag tccgagcggt acctccaaca gccatccccg cctatccagg tgtggtttac      960

caggacggat tttacggtgc tgacctctat ggtggatatg cagcctacag atatgcacag     1020

cctgctactg caaccgcagc caccgctgct gcagccgctg cagccgctta cagtgacggt     1080

tatggcaggg tgtacacagc cgacccctac catgcccttg cccctgccgc tagctatgga     1140

gttggcgctg tggcgagttt ataccgaggt ggctacagcc gatttgcccc ctactgaagt     1200

gacgtgagac ccctgcaaat gggacagccc cccagttcat gaggcctggc tatt           1254


<210> 2805
<211> 1966
<212> DNA
<213> Homo sapiens

<400> 2805
agaagtgcgg acgcccggct cccggcgtgg acgccatggt gctgtgcccg gtgattggga       60

agctgctgca caagcgcgtg gtgctggcca gcgcctcccc acgccgtcag gagatcctca      120

gcaacgcggg tctcaggttt gaggtggtcc cctccaagtt taaagagaag ctggacaaag      180

cctccttcgc tactccgtat gggtacgcca tggagaccgc caagcagaag gccctggagg      240

tggccaaccg gctgtaccag aaagacctgc gggcccccga cgtggtcatt ggagcggaca      300

cgatcgtggt tgagtgggag agaacacagc gtgttcacag gtgtcgcgat cgtccactgc      360

tccagcaaag accatcagct ggacaccagg gtctcggaat tctacgagga aacgaaggtg      420

aagttctcgg agctgtccga ggagctgctc tgggaatacg tccacagcgg ggagcccatg      480

gacaaagctg gcggctacgg gatccaggcc ctgggcggca tgctggtgga gtccgtacac      540

ggggactttc tgaacgtggt gggattcccg ctgaaccact tctgcaagca gctggtgaag      600

ctctactacc cgccccgtcc ggaggacctg cggcggagtg tcaagcacga ctccatcccg      660

gccgcggaca ccttcgaaga cctcagtgac gtggaggggg gcggctcgga gcccactcag      720

agggacgcgg gcagccgcga tgagaaggcc gaggcgggag aggcgggaca ggccacggca      780

gaggctgagt gtcacaggac tcgggagacc ctgcctccgt tcccgacacg cctcctggag      840

ctgattgagg gctttatgct atccaagggc ctgctcaccg cttgcaaact gaaggtgttc      900

gatttgttaa aagatgaagc accccagaag gctgcggata ttgccagcaa agtggacgcc      960

tctgcgtgtg gaatggagag gcttctggac atctgtgctg ccatggggct cctggagaag     1020

acagagcaag gttacagtaa cacagagaca gcgaacgtct acctggcatc ggatggcgaa     1080

tactctctgc acggcttcat catgcacaat aatgacctca catggaacct ctttacatac     1140

ctggagtttg ccatccgaga gggaacaaac cagcaccaca gggcgttggg gaagaaggcg     1200

gaagatctgt tccaggatgc gtactaccag agcccggaga cgcggctgag gttcatgcgg     1260

gccatgcacg gcatgacgaa gctgactgcg tgccaggtgg ccacggcctt caatctgtcc     1320

cgcttctcct ccgcctgcga cgtgggaggc tgcacgggtg cactggcccg agagctggcc     1380

cgtgagtacc ctcgtatgca ggtgactgtg tttgacctcc cagacattat cgagctggcc     1440

gcccacttcc aaccccccgg accgcaggca gtgcagatcc acttcgcagc aggtgacttt     1500

ttcagggacc ccctccccag cgctgagctg tacgtcctgt gccggatcct gcatgactgg     1560

ccagacgaca aagtccacaa gttactcagc agggtcgccg agagctgcaa gccaggggcc     1620

ggcctgctgc tggtggagac gctcctggat gaggagaaga gggtggcgca gcgcgccctg     1680

atgcagtcac tgaacatgct ggtgcagact gaaggcaagg agcggagcct gggcgagtat     1740

cagtgcttgc tggagctgca cggcttccac caggtgcagg tggtgcactt ggggggtgtc     1800

ctggatgcca tcttggccac caaagtggcc ccctgaagcc caggcagcat gttcattata     1860

gggatgtcct cccccaggct gcaggtggac cgcccggtcc ccaagtacca taggacagtc     1920

acataggagc gtgtagtcgt gactgaataa agaaagcaaa agcctg                    1966


<210> 2806
<211> 685
<212> DNA
<213> Homo sapiens

<400> 2806
gtgacaggaa atggagctgg ggagacaaaa atgtggataa caacaaaaga atttcaacag       60

gtaaaaaaat gagtcaaaca tctctcaaac agaaaaagaa tgagcctgga atgaggtcct      120

caaaagagag tctagaagca gaaaaaagaa aggaatctga caaaacagga gttcgtctga      180

gcaatcagat gaggcgtgca gtcaatccga atcactcgct gagatgttgc cccttccagg      240

gtcactcgtc gtgtagacgc tgcctttgtg cagctgaggg aacagccctt ggcccctgcc      300

acacaatacg tatttatatt cacatgtgcc tgttgtggga gcagggccag cagatcacca      360

tgatgagggt gagcagagat cacactaccg attctggagg ggaaccacag acaacctggg      420

gatcacaaga atcatcactg cggaagacag actctcgagg gtaccttgtg cgcagtcaat      480

ggtctagaat atcccggagc ccatccacca aggctccatc catagatgag cctagaagca      540

ggaacaccag tgctaagctc cccagcagct ccacgagctc ccggactcca tccacctccc      600

caagcctgca tgactcctca ccgccgccgc tgtccgggca gccctcgctc cagccacccg      660

cgtcgcccca gctgccccgg tcgct                                            685


<210> 2807
<211> 3116
<212> DNA
<213> Homo sapiens

<400> 2807
attcactgat tagatccagc gctgagaggc agcactgctc cttctctcac gccaactgag       60

tctcttgatc tgtacatgca atcccaggca gctcgcgaac acaaacccgg ggccagccgc      120

ctactgctgc tgctgctgct gccgctgccg ccgccgccgc cgccgctgcc tccgccggct      180

ctgcgaaccc gggacttttc atgcaccaca ctctccgcct gcttccctcc gtgtcctgaa      240

aagtgcgacc gttctcccaa ggaatttcca cggtcttagg agggaatgat tccccagtaa      300

tattccctgc cctgacccaa agtgctggtt ggcctccctc ccagggaaga ctgcttcttg      360

cgtaacgccg gccacagaaa gagactccga tggacttaca ccgggcagcc ttcaagatgg      420

agaactcatc ctaccttccc aaccctctgg catccccagc actgatggtc ctggcatcca      480

cggctgaggc cagccgtgat gcttccatcc cttgtcagca gccacgaccc tttggtgtac      540

ctgtctcagt tgacaaggac gtgcatattc ctttcaccaa cggttcctat acctttgcct      600

ctatgtacca tcggcaaggt ggggtgccag gcacttttgc caatcgtgat ttcccccctt      660

ctctactaca cctccaccct caatttgctc ccccaaatct agattgcacc ccaatcagta      720

tgctgaatca tagtggtgtg ggggctttcc ggccctttgc ctccaccgag gaccgggaga      780

gctatcagtc agcctttacg ccggccaagc gacttaagaa ctgccatgac acagagtctc      840

cccacttgcg cttctcagat gcagatggca aggaatatga ctttgggaca cagctgccat      900

ctagctcccc cggttcacta aaggttgatg acactgggaa gaagattttt gctgtctctg      960

gcctcatttc tgatcgggaa gcctcatcta gcccagagga tcggaatgac agatgtaagt     1020

acagagcagc ggcattgttc gacagccagg ccccaatttg ccccatctgc caggtcctgc     1080

tgaggcccag tgagctgcag gagcatatgg agcaggaact ggagcagcta gcccaactgc     1140

cctcgagcaa gaattccctt ctgaaggatg ccatggctcc aggcacccca aagtccctcc     1200

tgttgtctgc ttccatcaag agggaaggag agtctccaac ggcatcaccc cactcatctg     1260

ccaccgatga cctccaccat tcagacagat accagacctt tctgcgagta cgagccaacc     1320

ggcagacccg actgaatgct cggattggga aaatgaaacg gaggaagcaa gatgaagggc     1380

aggtatgtcc cctgtgcaac cgccccctgg caggatcgga gcaggagatg agtaggcatg     1440

tggagcattg cctttctaag agggaaggct cctgcatggc tgaggatgat gctgtggaca     1500

tcgagcatga gaacaacaac cgctttgagg agtatgagtg gtgtggacag aagcggatac     1560

gggccaccac tctcctggaa ggtggcttcc gaggctctgg cttcatcatg tgcagcggca     1620

aagagaaccc ggacagtgat gctgacttgg atgtggatgg ggatgacact ctggagtatg     1680

ggaagccaca atacacagag gctgatgtca tcccctgcac aggcgaggag cctggtgaag     1740

ccaaggagag agaggcactt cggggcgcag tcctaaatgg cggccctccc agcacgcgca     1800

tcacacctga gttctctaaa tgggccagtg atgagatgcc atccaccagc aatggtgaaa     1860

gcagcaagca ggaggccatg cagaagacct gcaagaacag cgacatcgag aaaatcaccg     1920

aagattcagc tgtgaccacg tttgaggctc tgaaggctcg ggtcagagaa cttgaacggc     1980

agctatctcg tggggaccgt tacaaatgcc tcatctgcat ggactcgtac tcgatgcccc     2040

taacgtccat ccagtgttgg cacgtgcact gcgaggagtg ctggctgcgg accctgggtg     2100

ccaagaagct ctgccctcag tgcaacacga tcacagcgcc cggagacctg cggaggatct     2160

acttgtgagc tatctgcccc aggcaggcct cgcctccagc agccccacct gcccccagcc     2220

tctgtgacag tgaccgtctc cctttgtaca tacttgcaca caggttcccc atgtacatac     2280

atgcacatac tcaaacatgc gtacacacac acacatttac acacgcagga ctctggagcc     2340

agagtagagg ctgtggccca ggcactacct gctggctccc acctatggtt tgggggccat     2400

acctgttcca gctctgttcc cagggtgggg cagggaggtg ggggttgggg gagtagtggg     2460

gcacggctcc taagatccag cccccatact gacagacgga cagacagaca tgcaaacacc     2520

agactgaagc acatgtaata tagaccgtgt atgtttacaa tgttgtgtat aaatgggaca     2580

actcctcgcc ctctacctgt cccctccccc tttggttgta tgattttctt cttttttaag     2640

aacccctgga agcagcgcct ccttcagggt tggctgggag ctcggcccat ccacctcttg     2700

gggtacctgc ctctctctct cctgtggtgt cccttccctc tcccatgtgc tcggtgttca     2760

gtggtgtata tttcttctcc cagacatggg gcacacgccc caagggacat gatcctctcc     2820

ttagtcttag ctcatggggc tctttataag gagttggggg gtagaggcag gaaatgggaa     2880

ccgagctgaa gcagaggctg agttaggggg ctagaggaca gtgctcctgg ccacccagcc     2940

tctgctgaga accattcctg ggattagagc tgcctttccc agggaaaaag tgtcgtctcc     3000

ccgaccctcc cgtgggccct gtggtgtgat gctgtgtctg tatattctat acaaaggtac     3060

ttgtcctttc cctttgtaaa ctacatttga catggattaa accagtataa acagtt         3116


<210> 2808
<211> 650
<212> DNA
<213> Homo sapiens

<400> 2808
gttctccgct gaggaggagc ggggcagagg agggaggcag cgggtgagag ttcagagttc       60

agcagcagca gcccgagccc atgattccca tatgccctgt agtttctttc acctatgtgc      120

ccagccggct gggggaagat gccaaaatgg cgaccggcaa ctactttgga ttcacccaca      180

gcggggcggc ggcggcggcg gctgcggccc aatatagcca gcagccagct tcgggtgtag      240

cctattctca tccaactaca gttgctagct acactgtcca tcaggctcca gtagctgctc      300

acacagttac tgctgcctat gcaccagcag ccgccacagt tgcagttgcc aggcctgctc      360

cagtagctgt tgcagctgct gcaacagctg ctgcttatgg aggctacccc actgcacaca      420

cagcaactga ctatggttat actcagaggc aacaagaagc accaccacca ccacccccag      480

ctactacaca aaactaccag gattcatact catatgtaag gtccacagct cctgctgtag      540

cttatgatag taagcaatac taccaacaac cagcagcaac agaagcaggc agcagcagca      600

gctgctgctg ctgctgcaac agctgcctgg acagggacca cctttactaa                 650


<210> 2809
<211> 991
<212> DNA
<213> Homo sapiens

<400> 2809
ggccgttacg cgattttcgc tcccgcgggc agcgcctctc aggccactcc cgagggaccc       60

cgaggacgca ctcgggcccc agggcgacgg ttcaaacggg ccattgtgcg cccccggggt      120

cccccggccc ctgcagggct acttgggcgc agagccgcgg agggtctccg ttcctagagg      180

tcctcctatc ccgggctgcc tgagtcctcg ccagcatccg ccctctccca ctcccatcct      240

tcctggatcc gcctctcggt tcccgaggga cagtcccgac cgcaaaccca cgtagagtaa      300

ggaatgtggg acaggcgaca gaagtggcat acggtcctgc gttatccctc cgtctcgcca      360

caccttgtgt ctccatctct ccccacttcc ttccctccgt ctgtcatctg tcatccccgg      420

tcgctctaag accaggattc caattcgcct agtgaggaat ctcactaggg gaatttatcg      480

cgacatcata aattaacggg ttcattttga ctgaaaaagc gaaggacttt tttcaggcag      540

aaaacaagtc tcgtctggac ggatgtgatc ttcgtggtgg aaagctaaat tttaaaacca      600

ccccaatgga tgcagacagt gatgttgcat tggacattct aattacaaat gtagtctgtg      660

tttttagaac aagatgtcat ttaaacttaa ggaagattgc tttggaagga gcaaatgtaa      720

tttataaacg tgatgttgga aaagtattaa tgaagcttag aaaacctaga attacagcta      780

caatttggtc ctcaggaaaa attatttgca ctggagcaac aagtgaagaa gaagctaaat      840

ttggtgccag acgcttagcc cgtagtctgc agaaactagg ttttcaggta atatttacag      900

attttaaggt tgttaacgtt ctggcagtgt gtaacatgcc atttgaaatc cgtttgccag      960

aattcacaaa gaacaataga cctcatgcca g                                     991


<210> 2810
<211> 567
<212> DNA
<213> Homo sapiens

<400> 2810
aggctaggcg tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg       60

ccccgcaggc ccaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc      120

ggaatttccc acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg      180

atcccagcat gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg      240

aggaggctgc agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg      300

tttctgaagg agaactagat cagttggctc agattcggcc attaatattc aattttcatg      360

agcagacagc catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata      420

tcatgcagga atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga      480

atcaaccaag caacagagaa aaaaacagat accgagatat tcttccattt caacatcatg      540

gatatagtgg cccaaatgag agaacaa                                          567


<210> 2811
<211> 4649
<212> DNA
<213> Homo sapiens

<400> 2811
gaggatgagt atatccagag tcataacttc gattctgcaa tgaaagtcac cagccaaggg       60

cagccctccc cagtggagcc ccgaggaccc ttttatttct gcaggttatt gcttgatgac      120

ttgggaatga attcttggga cagaaggaag aattttcatc tattgaagaa aaattcaaaa      180

ttattgagag agctgaaaaa tttggactcc cgccagtgcc gtgagacaca caaaatcgca      240

gtgttttaca ttgctgaagg tcaagaagac aagtgttcaa tcctctctaa tgaaagagga      300

agccaagcat atgaagactt tgttgctgga cttggatggg aggtggatct ctccacccac      360

tgtgggttca tgggtggcct tcagcgcaat ggcagcaccg ggcagacggc cccttactat      420

gctacctcaa ctgtggaagt gattttccat gtttccactc gaatgccgtc agactcagat      480

gattccctca ccaaaaagct tcgtcacttg gggaatgacg aggtccatat cgtctggtct      540

gaacactcca gagactaccg caggggtatt atcccaactg cctttggaga tgtttcaatc      600

attatttacc caatgaagaa tcacatgttc ttcatcgcga taacgaagaa acctgaggtt      660

ccattttttg ggcctctgtt tgatggagcc atagtgagtg ggaagctgct gccaagcctt      720

gtatgtgcca cgtgcatcaa cgccagcagg gctgtgaagt gcctcatccc actctaccag      780

agcttctatg aagagcgagc tctgtatctc gaagcaataa ttcagaacca ccgcgaagta      840

atgacattcg aggatttcgc agcccaagtc ttttctccct ctcccagcta ctccctcagc      900

ggaacggatt aaaacacgta aaggtctcat ttcaatattt gagcaagggg ccctggcctc      960

cagtctgagt gctgacctcg aagagcccct gagtgaggag gagacagaac accctctcct     1020

gcctctgccc cgagccacta aacccagaat ctccaggaaa tttcgttgct gtactagtgc     1080

cctcagcagg tcttcccatt agtggacttc tgaagcccat ggtgaatccc actaccgtgt     1140

ctcagatggg actcaaacta ggctgtatca tcttgtcctg aaacctcaca aaccttggac     1200

ttccaaagaa gaaaagaaaa agtcaccaaa aaccagagat gaacccactg acacgtgggc     1260

actggtgtgg ctgctctggg cagatgacag caggaaaaga ttctgcgctt tcagggaggg     1320

ggcagagggc agcttgcttc tgcaccccaa gttgtttctt ctcatttatg aacccaagca     1380

tgattcacaa aggggctggc aaaacaattg tctaattgag gaatctgatc tgcattgatt     1440

ttgctagttc cttttatgtt aggatttatg gtttactcaa aaatttcatc atcatggaaa     1500

ttggctttcc ccggggtctt ttgcccagga gaagttttac ctcagttgtc cagtgttttc     1560

ccacatggta cctgacgccc gctaactaag cagaggctct cctcaccacg cagaggcgct     1620

tcaggtcatg acagtgatgc ccctatctta gaacactcag aagattccag aaatacaggg     1680

tcctgtcctt gcataagttc ctgcaggaca ggaagtgtcc caaggctcaa aacaacacag     1740

accacatcca cacaaaaggc gcatgccggc ttcaggcgct aggctgagac gggtaccccc     1800

cgaatggcct tgtgcctcca aaagcctcac gctgcaactt tgctgctcct gtctgttgcc     1860

cagagaggcc tcacacaggc ctcagaaatg tttcttgtca cacaaagctt ttggtagccg     1920

attccaagcg agggatttaa tccttacatt tttgcccatt tggctccaag gaaggcttat     1980

tagacctgtt tttttgttgt tgttgttttt ttttcttaaa aacaaaatga atgaatgaat     2040

gaaaagagaa gcaatggtga gccctctcct gctggggcgc cctgggtggg ccttgcccgt     2100

cctgcagcag agaaatcagt cagcagcgaa gagctgctgg cgcaggcccc aggctgtgtc     2160

ctggaccctt gacctgcctc agagctagag gtttgctcca ccccgcactt cacttgggaa     2220

gtaaatccaa gaagcttacc agagtccatc gccactgcgc aggctttgtt ctcacagcgg     2280

ccaggtacag agcaacgccc tgcagtggga agggacagca gcacgagaga cgcagcccct     2340

aactcagggc ttatgatggg tgggctggtc ctgggaaagg cgggccctgt gcgggaggcc     2400

tccccacctt cctgtgccct ctgccctctg cccttgcaca cacttgttac cttcaggctg     2460

cttggccacc caggcctgaa gaagccttct gaggctctca ccccatcaga acggccattt     2520

tcactgagga gccagttttt tccatttgcc atggagctgg tttggctgga acctggcctt     2580

tgtagggaaa acggggagac tcaggagcca gactcactct tgggacaaat gagaaagagc     2640

tgagccagtc gttcctgtcg gaagggcggg cctgctcatc ctggcgagaa tttgcttttc     2700

tgctttatag gggattgcag gccaggccca ctgacaggag caccttgaga accacctgaa     2760

cagaagagaa tgagggtgcc ccaaagtgga aggaagcttc tggcccctgg gccgttttgg     2820

gaagggccca ggatactcac gggggctgaa gggcaatgtg aagagtgact gcaagtcctg     2880

gcattttctg tggtgtcagc aaatgcccct ttattttaaa tgattccaga catctgggca     2940

gcatagcttg gccaccatca ctcaggcttg atcctgctgt tgagctgctc ctgtctcctg     3000

tttacctcac tcctgttggg aaggccatcg catgctccta ggctccagag tcccctgtag     3060

gtctctacca gcaggtcgcc tctgggagaa cgtttcatct tcaggctcta gaaactcctg     3120

ttgcggaatt gctggcttta gtagaaaaga tatgtcagga tttagaaatc gtattgaact     3180

ctcctggact tctgctccat gatttcattt tgctttcacg aaccagcgat ccctaccttg     3240

gggtgggaaa ttcaattgta ggcagcaaat aactcaaccc tcctgtaacc cctgaggatt     3300

ataacgaccc catgaccccc gatgacagcc agcagtttgg tgactagagt tttttgagcc     3360

tgccattctc agtagcagct ttggtctgga gatggaacgt ggagcaggga atctgacagc     3420

cacgtttctc gtgatcacgt ggactggagt tgtttttgtt atctggggtg gaaaattgca     3480

atgatcaagt ttctttttta tttttttttt acttagaaaa gcaaatattg tgtttttgta     3540

ataaatccct ttcagcaaaa ttgcggagga tcattcatcc actagggccc cacctgaggc     3600

acagcgctga ctcatcacgg tggtaccagt aggtcagcca tctggaaaca gaagtggccc     3660

taattgggcc aaaatgtggt aagactcgct ggcctcaggc agggccaggc cagttccctc     3720

acttctctgc acacctattc ccagattcca tccagagcaa agctgatgtt tatcgtctca     3780

ttgtacttag gctttcgtac tttaaaaaat tatgactttt taaaaataag ccttcagcag     3840

acagaagtga agaaatttag cctgggttgc ctcagcaaca aagtctgcgg ttcctaagag     3900

ccacatgttg gggaagtggg gtgacccaaa cttggtgaca taggttgatt gatcagaccc     3960

tcagccttac aagcaagagc tcatgcagat ccacagagcc atgcacatcc tgtcttcctg     4020

accttcctca ggtggcacca cctgcgcccc atggacctgc tgtatcggtg tcatgtggag     4080

gtctgatgaa tcctttaaaa cctaactgtg atgtcgtaaa tgtaactgtg ctacctttat     4140

atctactgaa gggcagcgtc tgcatccgag ggaaattcaa catgaaacaa ccatcgtttt     4200

agttgcactc agtctgtcca tatgacatac acatgaagtg aatgtttcct tatgttttca     4260

ggtctacaat gtttagtaca tgtaaataag gaaaaaattt gataaatatg gtaaattaag     4320

ttatagcgtg tcatttgatt cttattttgc tgtctcttgt tatttaattt tcctaatgct     4380

ccacatctag gttccttcct aggtggtggg aacaccttgc agacgtgtgt gcaccaggac     4440

acaccgcggc ccaggcagcc acaccgagaa agcacacatc tccactgatg gcagccaccc     4500

gactctccag ttaacctctt ttactcttta attctgattt actgtgatga tttaataaag     4560

tggaaacaca gcacttcagt gctatatgtt tctctcattc tcattatagt ttataagaaa     4620

ataaagttca ccctggcatc taataaaaa                                       4649


<210> 2812
<211> 3535
<212> DNA
<213> Homo sapiens

<400> 2812
tagggcacgg gaagggctcg ctagaatgag ctcttaaact ggttgggtgt aagcggtttt       60

gggctagtct aaaccaaaca actgagaata aacgcggggt tcctgcaggt tgagagagta      120

cctgtctgca aatgtccagt agtgatggat tgccttgtag gccccagagc aatcggggaa      180

gttagcattc ttgttcaaga agctgctggt tcacttagag ctataaaaga atgttgtgag      240

tttggatttt cttccaaacg ttcaggattg aggttagggc tggtggtgag ggatcatgta      300

aagaggtttg agtggctcag ccttaggtcc cggtgtggaa agcttattct tttggtgtca      360

tcacgtggcc gtgggaatta tttagaatgt gatctgccct catgagaaga aaggagctct      420

gaagccgttg cagttcttcc tccctatgtg gaaaatcgaa tttctggaaa catcctccgt      480

attgggagat tttgcctatg taaaggctat ccttattggc tagcggcact aattacttta      540

aaagtaggat ggaagtacaa gtatctcaag catcattggg tttcgagctc acttctgtgg      600

aaaagagttt aagggagtgg tctagacttt ccagggaagt tattgcctgg ctgtgtccct      660

ctagtcctaa ttttatactt aactttcccc cacctccttc agcctcatct gtttcaatgg      720

tgcaactctt ttcatcccct tttggttacc agtcaccttc aggccattca gaggaggaaa      780

gagaggggaa tatgaagtca gccaagcccc aagtgaacca cagtcagcat ggggaaagcc      840

agcgggcctt gagccccctg cagtctactc tgagttctgc tgcatctcct tcccaagcgt      900

atgagaccta tattgaaaat ggactcatat gccttaaaca caaaattaga aacatcgaga      960

aaaagaagct caaactggag gattataagg atcgcctgaa aagtggagag catcttaatc     1020

cagaccagtt ggaagctgta gagaaatatg aagaagtgct acataatttg gaatttgcca     1080

aggagcttca aaaaaccttt tctgggttga gcctagatct actaaaagcg caaaagaagg     1140

cccagagaag ggagcacatg ctaaaacttg aggctgagaa gaaaaagctt cgaactatac     1200

ttcaagttca gtatgtattg cagaacttga cacaggagca cgtacaaaaa gacttcaaag     1260

ggggtttgaa tggtgcagtg tatttgcctt caaaagaact tgactacctc attaagtttt     1320

caaaactgac ctgccctgaa agaaatgaaa gtctgagtgt tgaagaccag atggagcagt     1380

catccttgta cttttgggac cttttggaag gtagtgagaa agcagtggta ggaacgacat     1440

acaaacactt gaaggatcta ctgtctaaat tgctgaactc aggctatttt gaaagtatcc     1500

cagttcccaa aaatgccaag gaaaaggaag taccactgga ggaagaaatg ctaatacaat     1560

cagagaaaaa aacacaatta tcgaagactg aatctgtcaa agagtcagag tctctaatgg     1620

aatttgccca gccagagata caaccacaag agtttcttaa cagacgctat atgacagaag     1680

tagattattc aaacaaacaa ggcgaagagc aaccttggga agcagattat gctagaaaac     1740

caaatctccc aaaacgttgg gatatgctta ctgaaccaga tggtcaagag aagaaacagg     1800

agtcctttaa gtcctgggag gcttctggta agcaccagga ggtatccaag cctgcagttt     1860

ccttagaaca gaggaaacaa gacacctcaa aactcaggtc tactctgccg gaagagcaga     1920

agaagcagga gatctccaaa tccaagccat ctcctagcca gtggaagcaa gatacaccta     1980

aatccaaagc agggtatgtt caagaggaac aaaagaaaca ggagacacca aagctgtggc     2040

cagttcagct gcagaaagaa caagatccaa agaagcaaac tccaaagtct tggacacctt     2100

ccatgcagag cgaacagaac accaccaagt catggaccac tcccatgtgt gaagaacagg     2160

attcaaaaca gccagagact ccaaaatcct gggaaaacaa tgttgagagt caaaaacact     2220

ctttaacatc acagtcacag atttctccaa agtcctgggg agtagctaca gcaagcctca     2280

taccaaatga ccagctgctg cccaggaagt tgaacacaga acccaaagat gtgcctaagc     2340

ctgtgcatca gcctgtaggt tcttcctcta cccttccgaa ggatccagta ttgaggaaag     2400

aaaaactgca ggatctgatg actcagattc aaggaacttg taactttatg caagagtctg     2460

ttcttgactt tgacaaacct tcaagtgcaa ttccaacgtc acaaccgcct tcagctactc     2520

caggtagccc cgtagcatct aaagaacaaa atctgtccag tcaaagtgat tttcttcaag     2580

agccgttaca ggctacttct tctccagtta cttgtagctc aaatgcttgc ttggttacta     2640

ccgatcaggc ttcttctgga tctgaaacag agtttatgac ctcagagact cctgaggcag     2700

caattccccc aggcaagcaa ccgtcttcac tagcttctcc aaatcctccc atggcaaagg     2760

gctctgaaca gggcttccag tcacctccag caagtagtag ttcagtaacc attaacacag     2820

caccctttca agccatgcag acagtattta acgttaatgc acctctgcct ccacgaaaag     2880

aacaagaaat aaaagaatcc ccttattcac ctggctacaa tcaaagtttt accacagcaa     2940

gtacacaaac accaccccag tgccaactgc catctataca tgtagaacaa actgtccatt     3000

ctcaagagac tgcaaattat catcctgatg gaactattca agtaagcaat ggtagccttg     3060

ccttttaccc agcacagacg aatgtgtttc ccagacctac tcagccattt gtcaatagcc     3120

ggggatctgt tagaggatgt actcgtggtg ggagattaat aaccaattcc tatcggtccc     3180

ctggtggtta taaaggtttt gatacttata gaggactccc ttcaatttcc aatggaaatt     3240

atagccagct gcagttccaa gctagagagt attctggagc accttattcc caaagggata     3300

atttccagca gtgttataag cgaggaggga catctggtgg tccacgagca aattcgagag     3360

ctaactgctt cattatgaga aactcactgt tgctaataaa acagcagggt ggagtgattc     3420

ttctcaggtg agcagcccag aaagagacaa cgaaaccttt aacagtggtg actctggaca     3480

aggagactcc cgtagcatga cccctgtgga tgtgccagtg acaaatccag cagcc          3535


<210> 2813
<211> 2724
<212> DNA
<213> Homo sapiens

<400> 2813
aataacaatg gaacatatga tggtattgca tattttgagt gcaaagaaaa gcatggtatt       60

tttgctcctc ctcaaaaaat atctcacatt ccagaaaact ttgatgacta tgtagacatt      120

aatgaagatg aagactgtta ctcagatgaa cgatatcagt gctataatca agagcaaaat      180

gatacagagg gtccaaaaga cagagaaaag gatgtcagtg aatattttta tgagaaatcc      240

ctacctagtg tgaatgatat agaagcctca gttaatagaa gtagaagcct taaaatagaa      300

acagacaatg tacaggacat ttctggggta cttgaagccc atgttcacca gcagtcttca      360

gtggattcac agatttcttc aaaggaaaac aaagacctca tttctgatgc cacagaaaag      420

gtttccatcg ctgcagaaga tgacacttta gacaatacct tttccgaaga attggagaag      480

caacagcagt ttacagaaga ggaagacaac ctatatgctg aagcttcaga aaagctttgt      540

acaccacttc tggatctttt aacaagagaa aaaaaccaac tggaagccca gctgaagtca      600

tcactaaatg aggaaaaaaa gtcaaaacaa caactggaaa aaatcagctt actgacagac      660

agtttactaa aagtctttgt aaaggacaca gtcaatcaac tacaacaaat caaaaaaacc      720

agggatgaga aaatccagct tagcaatcag gagcttcttg gtgatgacca aaagaaagta      780

acaccccaag acctatccca aaatgttgag gaacagtcgc caagtatttc aggttgcttc      840

ttaagttctg aattggaaga tgaaaaagaa gagatttcct ctccagatat gtgtcccaga      900

ccggagagcc cagtatttgg tgccagtggg caggaagaac ttgctaagag acttgctgaa      960

cttgaactca gccgggagtt cctgagcgcg ttaggagatg atcaagactg gtttgatgaa     1020

gactttggtt tgagctcttc tcacaagatc caaaaaaata aggcagaaga aaccattgta     1080

cctctaatgg cagaacctaa aagagtaacc caacaaccat gtgaaacatt attggcagtc     1140

ccccatactg cagaagaagt agagattctt gtacataatg cagcagaaga actttggaaa     1200

tggaaagaat taggccacga tcttcatagc atcagtattc ctacaaaact gcttggctgt     1260

gccagtaaag gtctagatat agaaagcact agtaaaaggg tctacaaaca ggcggttttt     1320

gatttaacaa aagagatttt tgaggaaata tttgctgagg atcccaactt aaatcaacct     1380

gtctggatga agccatgtag aatcaactct agttatttcc gacgagtgaa aaatccaaat     1440

aaccttgatg aaatcaagag cttcatagca agtgaagtac tcaagttgtt cagtcttaaa     1500

aaggagccaa accacaaaac agattggcag aaaatgatga aatttggaag aaagaaaaga     1560

gaccgagtgg atcatatcct ggttcaggag ctccatgagg aggaggcaca gtgggtgaac     1620

tatgatgagg atgagttgtg tgtgaaaatg cagctagccg acgggatctt tgagaccctg     1680

atcaaagata ctattgatgt tctgaatcag atcagtgaaa agcaggggag aatgctactt     1740

gtgtgacatc ttgcaaataa atcgaacgct gagtgctaat cattgcttct cacaactatt     1800

acctgcatct gaaaaaaaat ctatagactc cagctgctac attagagcat aagagatgct     1860

ctcctgggac ctcagtaccc tgccttcttg actggtttcc gttcatcagt cctgtccctc     1920

ttcaagtaat ctagaagaat gtggatactc ttaggcgtga atgtaaatgc cttaatattg     1980

aaggtcctgg ttagaagcat gatacaagac atctactgga ttcatattta caaatatcct     2040

ggaatgttat agcttcaaag tatattagaa aaaccccaaa gatggtataa tctttaagtg     2100

tgcacgttcg tttatttctg catcttccct ccaaacttgc ctttgcatct taaatatttc     2160

actatgcaca ctcccattcc tcttgggttt catcttgtcg tttaagaaat gtactgaaat     2220

aatcattgga atatttgcat tttgcacaat gactggtatg atagctcttg acaaataagg     2280

aaagcactga aatgttgtga ttgggtctcg ggaaatgctc agattgatgt cttaccagca     2340

tttcttctgg gcttgtgatg ttgagctgta gtcttgtagc cataatgagc aaattgacta     2400

agagaagcaa aggtttcttg gggttattaa ccagtagtgt ggaaatacta gttttatgtg     2460

gccaaggaaa agcaaaggct tttcttttca gtttgtgtta tttggaagac agaaaaacat     2520

cttgtctaca tcctttggct gtttgtagga tcacgttgtc cttacgatac tgaaacttta     2580

cagctgctgt aaatttttta taaatgaatt tcaaaatgtt ataatgggac tgtaggttgt     2640

ttttctacat cttcattatt tggacctaaa accagttttt aataagaaag tttatcttta     2700

ctctttctga aattatgact ccag                                            2724


<210> 2814
<211> 535
<212> DNA
<213> Homo sapiens

<400> 2814
cggagggagg cgggactcaa gagtagcctt cctcgaggac ctgcctttcc catttgctgc       60

ctgaagttaa tgtttcttgc tggccaaatc agggacatgc cggcattccc cacccacagc      120

cagggggctt gggttctgag ctgatggggt acccccctct gcagagcggg atgagtgggt      180

gttccggcag ggatgtggtc attgacggcc agtgagggcg agagtaccac ggcccacttc      240

ttccttggag ctggagatga ggggctgggc acccgtggaa taggcatgag gccagaagag      300

agtgacagcg agctccttga ggatgaggag gatgaagtgc ctcctgaacc tcagatcatt      360

gttggcatct gtgccatgac caagaaatcc aagtccaagc caatgactca aatcctagag      420

cgactctgca gatttgacta cctgactgtt gtcattctgg gagaagatgt aatccttaat      480

gaacctgtgg aaaactggcc atcctgccac tgcctcatct ctttccactc caaag           535


<210> 2815
<211> 1289
<212> DNA
<213> Homo sapiens

<400> 2815
acgccagcct tgatgatctg accatggagg ctgagtcctt cccatgcctc ctacggccat       60

tttttaaaga aagatcttgt gctttgcgcc cagccttcca tacagcaaag tgcgagaaac      120

tacaaaagga gaaggaggag ctggagaggc ggttcgaggc ggaaatggcg cgcctgcagg      180

aggagcacgg tgaccagctg ctgagcatcc ggtgtcaaca ccaggagcag gtggaagatc      240

tcaccgccag ccatgatgct gctctcctag agatggaaaa taaccacaca gttgccatca      300

caatcctgca ggatgaccac gaccacaaag tccaagaatt gatgtccact catgagcttg      360

aaaagaaaga attggaagaa aattttgaaa aactgcggct gtcattgcag gaccaggtgg      420

acacgctgac cttccagagc cagtctctgc gggacagagc ccgccgcttc gaagaggcct      480

tgaggaagaa cacagaggag cagctggaga ttgcattggc tccttatcag cacttggaag      540

aagacatgaa gagtctgaag caggtattag aaatgaagaa tcagcaaata cacgagcaag      600

aaaagaagat tcttgagctg gaaaagctgg cagaaaagaa cattatccta gaagaaaaga      660

tccaggttct ccaacagcag aacgaagacc tcaaagcaag gattgaccaa aacacagttg      720

tcaccagaca gctgtcggag gaaaatgcta acctccagga atatgttgag aaggaaaccc      780

aggagaagaa gagattgagc cgaaccaatg aagagctgct ttggaagctc caaactgggg      840

acccgaccag tccgattaaa ctctcgccca catctcccgt ttaccgcggc tcctcctcgg      900

ggccctcctc tccggccaga gtcagcacaa cacccagatg acgccactac acggcctgcg      960

ggagctccgg cttctcgtcc tccggtctcc accctgaggg agcaccgacc cggtgccgcc     1020

ggagctggcc ctgtgcgcat gctcagtagc tgcgaatgca tcctaggcgc gtcctcctct     1080

gatccccgtg taagactgcc ctggtgtcgg cacttaggaa tgtgtaaatg gtaaagtctg     1140

atgtgcaaac gttttaccat agttagagcc aaaagaaaga cacttgcaat tgttcttgag     1200

caatgaactt tcactgcaga atttcaggtt agttacaaaa agctcagttt tcaatataca     1260

ttgaataatc attgtgtact gcaccgata                                       1289


<210> 2816
<211> 2749
<212> DNA
<213> Homo sapiens

<400> 2816
acgctcactt ccgccgccgt cgggggctgc gcgggggctg tggctccggg actgcggtta       60

aaattgcaga gttttctcgt actccagaag actttctaaa gaaatatgat gaactgaaat      120

ctaaaaatac aaggaacctt gacccgctgg tgtacctgtt gtcaaagctc acggaagaca      180

aagagactct gcagtactta caacagaatg caaaagaaag agctgagctt gcagccgctg      240

ctgtgggcag cagtaccacc agcatcaacg tccctgccgc ggcctccaag atctccatgc      300

aggagcttga ggaactgagg aagcagcttg gcagcgtggc cacaggctcc acgctgcagc      360

agtctctgga acttaaaaga aagatgcttc gagacaagca gaacaaaaaa aattcaggcc      420

agcacctccc catcttccca gcatgggtgt atgagagacc tgccctgatc ggggatttcc      480

tgattggtgc tggcatcagc acagacaccg ctttgccgat aggcacgttg cccctggcct      540

cgcaggagtc ggccgtggtg gaggacctgc tgtacgtgct ggtgggcgtg gacgggaggt      600

acgtcagtgc tcagcccctg gctgggaggc agagccggac cttcctcgtg gaccccaacc      660

tggacctgtc catcagggag ctggtgcaca ggatcctccc agtggccgcc agctactccg      720

ctgtgaccag gttcattgaa gagaagtctt ccttcgagta cgggcaggtg aaccacgccc      780

tggcggccgc catgcgcacc ctggtgaagg agcacctgat tctggtgtca cagctggagc      840

agctgcacag gcagggcctc ctttcgctgc agaagctctg gttctacatc cagccagcca      900

tgcgcaccat ggacatcctg gcctccctcg ccacctcggt ggacaaaggc gaatgtcttg      960

gggggtccac gctgagcctg ctccacgaca ggagcttcag ctacacaggg gacagccagg     1020

cgcaggagct atgcctgtac ctaaccaagg cggccagtgc tccctacttc gaggttctgg     1080

agaagtggat ctacaggggc atcatccacg acccatacag tgagtttatg gtcgaggagc     1140

acgagctgcg gaaggagagg atccaggagg attacaacga caagtactgg gaccagcggt     1200

acaccatcgt ccagcagcag atcccgtcct tcctgcagaa aatggcggac aagatcctca     1260

gcacaggaaa atatctaaat gtggtcagag agtgtggcca tgacgtcacc tgcccggtgg     1320

ctaaagagat catctacacg ttaaaagagc gggcgtatgt ggagcagatc gagaaggcgt     1380

ttaactacgc cagcaaggtg ctgctggact tcctgatgga ggagaaggag ctggtggctc     1440

acctcaggtc catcaagcgc tacttcctca tggaccaggg cgacttcttc gtgcacttca     1500

tggacctcgc ggaggaggag ctccggaagc cggtggagga catcacgccc cctcgcctgg     1560

aagcgctcct ggagctggcg ctgcgcatga gcacggccaa cactgacccc ttcaaggacg     1620

acctcaagat cgacctgatg ccccatgacc tcatcactca gctcttgcgc gtcctggcca     1680

tcgagaccaa gcaggagaag gcgatggcgc acgccgaccc cacggagctg gcgctgagcg     1740

gcctggaggc cttctctttc gactacatcg tcaagtggcc cctttcgctc atcatcaaca     1800

ggaaagccct cactcgctac cagatgctct tcaggcacat gttctactgc aagcacgtgg     1860

agcggcagct ctgcagcgtc tggatcagca acaaaaccgc caagcagcac tcgctgcact     1920

ccgcccagtg gtttgctggg gctttcactc tgcggcagcg aatgctcaac ttcgtccaga     1980

atattcaata ctacatgatg tttgaagtga tggaaccgac ctggcacatc ctggagaaaa     2040

acctgaaatc cgcctccaac attgacgacg tccttggcca ccacacaggc ttcctggaca     2100

cctgcctgaa ggactgcatg ctcaccaacc ccgagctgct gaaggtcttc tccaagctca     2160

tgtctgtgtg cgtcatgttc accaactgca tgcagaaatt tacacagagc atgaaattag     2220

atggcgagct gggcgggcag acgctggagc acagcaccgt cctggggctg cccgcagggg     2280

ccgaggagcg ggcccggaag gagctcgcca ggaagcacct ggctgagcac gcagacactg     2340

tgcagctggt gtccggcttc gaggccacca tcaacaagtt tgacaagaac ttctcagccc     2400

acctgctgga cctcctggcc cggctgagca tctatagcac cagtgactgt gagcacggca     2460

tggccagcgt catctccagg cttgacttca atggtttcta cacggagcgc ctggagcgcc     2520

tgtctgcaga gaggagccag aaggccaccc cccaagtgcc tgtcctgcgg gggcccccgg     2580

ctcctgcacc cagggtcgca gtcaccgcac agtgagccct ggctgtgaca ggaaggaagg     2640

gtgtggggtc agcagggact ggtgcaaatg ggtccagaat tttcaaatcg aatgctctgt     2700

gttctgtctt tgcagtttaa atataaagca ggaatgattg actcagctc                 2749


<210> 2817
<211> 1468
<212> DNA
<213> Homo sapiens

<400> 2817
gggccgtgcg cggcggccgt gcgggcacgc catggacttc aacatgaaga agctggcgtc       60

ggacgcgggc atcttcttca cccgggcggt gcagttcacg gaggagaaat ttggccaggc      120

tgagaagact gagcttgatg cccactttga aaaccttctg gcccgggcag acagcaccaa      180

gaactggaca gagaagatct tgaggcagac agaggtgctg ctgcagccca accccagtgc      240

ccgagtggag gagttcctgt atgagaagct ggacaggaag gtcccctcaa gggtcaccaa      300

cggggagctg ctggctcagt acatggcaga cgcggccagt gagctggggc cgaccacccc      360

ctatgggaag acactgatca aggtggcaga agctgaaaag caactgggag ccgcggagag      420

ggattttatc cacacggcct ccatcagctt cctcacaccc ttgcgcaact tcctggaggg      480

ggactggaag accatctcga aggagaggcg gctcctccaa aaccggcgtc tggacttgga      540

tgcctgcaaa gcgaggctga agaaggccaa ggctgcagaa gccaaagcca cgacggtgcc      600

tgactttcag gagactagac ctcgtaatta cattctctcg gccagcgcct ccgcgctctg      660

gaatgatgaa gtggacaagg ccgagcagga gctccgcgtg gcccagacag agtttgaccg      720

gcaagcagaa gtgacccgtc tcttgctgga gggaatcagt agcactcacg tgaaccacct      780

gcgctgcctc cacgagttcg tcaagtctca gacaacctac tacgcacagt gctaccgcca      840

catgctggac ttgcagaagc agctgggcag ctcccagggt gccatatttc ccggcacctt      900

cgtgggcacc acagagcccg cctccccacc cctgagcagc acctcaccca ccactgctgc      960

ggccactatg cctgtggtgc cctctgtggc cagcctggcc cctccggggg aggcctcgct     1020

ctgcctggaa gaggtggccc cccctgccag tgggacccgc aaagctcggg tgctctatga     1080

ctacgaggca gccgacagca gtgagctggc cctgctggct gatgagctca tcactgtcta     1140

cagcctgcct ggcatggacc ctgactggct cattggcgag agaggcaaca agaagggcaa     1200

ggtccctgtc acctacttgg aactgctcag ctaggcaggt gcccccatcc cccccgcatt     1260

ctggcctagg caggagagga tgggcgcagc cctgccactt aacttgtttg ttggtgacac     1320

agttgttcag agtggggaga attcacccca ttctgtccct gcccctagtc acctagctgt     1380

gagggtgcct gaggctgaat ggctccaccc ctcccccagc cctgcttctg acctgtggct     1440

ctggagcccc tgcccctgcc tgcatccc                                        1468


<210> 2818
<211> 2340
<212> DNA
<213> Homo sapiens

<400> 2818
aaaaggcctc agcctgatgc ccacaggcag agcacacagg cagccgagtg gccgcagccc       60

tgcagtggag gagtgcctcg tgcacctggt ggttttctgc accccaacag gtgtgtctgg      120

ccactgctcc tctcactgca gcccccgctg ctccacacca tgcccttctg gcccatcagg      180

tgtctgaaga ggagcaggcg tatgcccagg ggtggtgccg gggagcggga gaaggtgccg      240

gccaaccccg aggcgctcct gctcatggcc agctcccagc gtgacatgga ggactgggtg      300

caggccatcc gccgagtcat ctgggccccg ctgggcggag ggatctttgg gcagcgccta      360

gaggaaacag tccaccacga gcggaagtat ggcccccgcc tggcgcccct gctggtggag      420

cagtgtgtgg acttcatccg ggagcgcggg ctcactgagg aggggctgtt ccgcatgcca      480

ggccaggcca acctggtgag ggacctgcag gattccttcg actgtgggga gaagccactg      540

tttgacagca caacagacgt gcacacggtg gcctccctgc tgaagctgta cctgcgggag      600

ctccccgagc ccgtggtccc cttcgccagg tacgaggact tcctcagctg cgcccagctg      660

ctcaccaagg acgaggggga gggcactctg gagttggcta aacaagtgag caaccttcct      720

caggcaaatt acaacctgct cagatacatc tgcaagtttc tggatgaagt tcaggcatac      780

tcaaatgtca acaagatgag tgtccagaat ctggcaaccg tttttggacc taacattctg      840

cggccacagg tagaggaccc agtaaccatc atggaaggca cttccctcgt ccagcacctg      900

atgaccgtcc tcatccgcaa acacagccag ctcttcacgg caccggtccc ggaagggccc      960

acctccccgc gcgggggcct gcaatgcgca gtggggtggg gctccgagga ggtcaccagg     1020

gacagccaag gagagcccgg cggccccggc ctgcccgcgc acaggacctc ttccctggac     1080

ggggcggccg tggcggtgct ctccagaaca gcccccacgg ggccggggag ccggtgcagc     1140

cctgggaaga aggtgcagac cctgcccagt tggaagtcct ccttccggca gccgaggtcc     1200

ctatcgggaa gcccgaaggg gggcggctca tccctggagg tgcccatcat ctcctccggc     1260

gggaactggc ttatgaacgg gctgtcctcc ctgcgcggac accgccgggc ctcgtcggga     1320

gaccggctca aggactcggg ctccgtgcag agactctcca cctacgacaa tgtgcccgcg     1380

ccgggcctgg tccccggcat acccagcgtg gccagtatgg cgtggtccgg ggcctcgtcc     1440

agcgagtcgt cggtgggggg ctcactcagc agctgcacgg cctgccgcgc cagcgactcg     1500

tctgcccgca gttccctgca caccgactgg gccctggagc cctccccgct ccccagcagc     1560

agcgaggacc ccaagtccct ggacctggac cacagcatgg acgaggcggg cgcgggtgcc     1620

agcaacagcg agcccagcga gccggacagc cccacccggg aacacgcgcg ccgctccgag     1680

gccttacagg ggctggtcac tgagctcagg gccgagctgt gccgccagcg gactgagtac     1740

gagaggagtg tgaaaagaat cgaagaaggg agtgctgacc tgagaaaacg aatgtcccgg     1800

ttagaagaag aactggacca ggaaaagaaa aaatacatca tgctggaaat aaagctgcgg     1860

aactctgaac gggcgcggga ggatgcggag aggaggaacc agctgttgca gagggaaatg     1920

gaggagtttt tttcgaccct aggaagcttg actgttgggg caaaaggtgc cagggcccca     1980

aagtaaaagg aatggcagag ctcacttctg taccacgtct gctggtctcc agccttgtat     2040

ggagttagaa gcgtctgtat ctctggagca gccaggcgct ctggagccag ctggagagag     2100

agagatcctg atacctctgt ggggactgtg gggacttttg ggaccccaca cactccaggt     2160

gggatcagat gctgctccaa ccatgcagtt cctggtgagg gtcagaaggg gacggtacca     2220

agagtagcgc ttagccctta cccaggaaat atccttcatg gccacagaaa tggagggcgc     2280

ccaggatcca ggcagccacc gggaacagtc agctttcttt attaaatgtg ctcacaaagc     2340


<210> 2819
<211> 1943
<212> DNA
<213> Homo sapiens

<400> 2819
gaaaatgagg gttatattaa aaagctcctg gagctttttc atgtgtgtga agatttggaa       60

aatattgaag gactgcacca cttgtatgaa attatcaaag gcatctttct cttgaatcga      120

actgctcttt ttgaagttat gttctctgaa gaatgtataa tggacgtcat tggatgttta      180

gaatatgatc ctgctttatc acaaccacga aaacacaggg aatttctaac aaaaacagcc      240

aagtttaaag aagtgattcc catatcagat cctgagctga aacaaaaaat tcatcagaca      300

tacagagttc agtatataca agatatggtt ctaccaactc cttcggtctt tgaagaaaac      360

atgttatcaa cacttcactc ttttatcttt ttcaataagg tagagattgt tggcatgttg      420

caggaagatg aaaaatttct gacagatttg tttgcacaac taacagatga agcaacagat      480

gaggaaaaaa gacaggaatt ggttaacttt ttaaaagaat tttgtgcgtt ttcccaaacg      540

ctacagcctc aaaacagaga tgcttttttc aagactttgt caaacatggg catattacca      600

gctttagaag tcatccttgg catggatgat acacaggtgc gaagtgctgc tactgatata      660

ttctcatact tggttgaata taatccatcc atggtacgag agtttgtcat gcaggaggca      720

caacagaatg atgatgtaag taagaagtta acagagcaaa aaataaccag caaggtaaat      780

attatttgta ctaatagtaa gtatttatac ataggaagct ataactgttt ttattattca      840

ttttaagatt taattgttgc tgtttgggaa aagtgtagcc ataatatcag acagcttatt      900

gttcccctaa attggttcct gtctcagttt atcaatttgt cctacagcaa ctatttatgt      960

tcatttaaat tgccttttaa aatattcatg tcagtttttt tttgttttgt tttgttttaa     1020

ttctgaagtc aacttgctat attgtgtttt ttaaatcatt tagtcaatca attcttgtat     1080

ctggggaatt aagagtaagt tacctaggaa aacattgact ttagggtaga ttctcaaaat     1140

cgccaagaat gaagaaatgt agcacagtcc cttaaaatat gaagggtgct gtttctttac     1200

tgcctagcca tagagaacaa gctgttacgt tgttcacaaa cactcacgtt agcatctgag     1260

atataccaga ttttaaagta gtagagaata tatcctggta atgtgaaggg tgcgcctgga     1320

tcacatagtg cgtgacatgt gagagcacta aatgtgtgtg ctctccttta ttttaaaata     1380

attgaaccaa tgattctgat tttttcctgc ttcccccata acaatttgga agcaactttt     1440

tacgtaagaa tgagtaagaa ggacctgctc tcaggtcctt cttaagggag gaggggaata     1500

aagatcccct aaggaaaaaa aaaaaatctg tttagaattc cagcctgtgg tatttttacg     1560

aaataggaaa atagactgtc ttactttttg aaaagatcct atttaatgta ttgtgatgtc     1620

aaaaggaaat ggaatgccat gtaactgcta tgtttaagtt tttattttta tagtgcagga     1680

taggtgcaaa aaagcaccag tttgaactgt tgtgtcatgt ttttctttta taaaatatta     1740

acatcggcct cagcaacata gcaagaccct cctttagtac aaaattaatt tttaaaactt     1800

agatatggtg gcatgcaccc atagtcccag atactcagga ggatgagaag gaagagtctc     1860

ttaagaccag gagtttgact ctgcagtgag ctatgattgc tccactgcac tccagtctgg     1920

gtgacgaagc cagaccccat ctc                                             1943


<210> 2820
<211> 4251
<212> DNA
<213> Homo sapiens

<400> 2820
gtctataagg gtcgacatgt taaaacgggt cagttggcag ccatcaaagt tatggatgtc       60

actgaggatg aagaggaaga aatcaaactg gagataaata tgctaaagaa atactctcat      120

cacagaaaca ttgcaacata ttatggtgct ttcatcaaaa agagccctcc aggacatgat      180

gaccaactct ggcttgttat ggagttctgt ggggctgggt ccattacaga ccttgtgaag      240

aacaccaaag ggaacacact caaagaagac tggatcgctt acatctccag agaaatcctg      300

aggggactgg cacatcttca cattcatcat gtgattcacc gggatatcaa gggccagaat      360

gtgttgctga ctgagaatgc agaggtgaaa cttgttgact ttggtgtgag tgctcagctg      420

gacaggactg tggggcggag aaatacgttc ataggcactc cctactggat ggctcctgag      480

gtcatcgcct gtgatgagaa cccagatgcc acctatgatt acagaagtga tctttggtct      540

tgtggcatta cagccattga gatggcagaa ggtgctcccc ctctctgtga catgcatcca      600

atgagagcac tgtttctcat tcccagaaac cctcctcccc ggctgaagtc aaaaaaatgg      660

tcgaagaagt tttttagttt tatagaaggg tgcctggtga agaattacat gcagcggccc      720

tctacagagc agcttttgaa acatcctttt ataagggatc agccaaatga aaggcaagtt      780

agaatccagc ttaaggatca tatagatcgt accaggaaga agagaggcga gaaagatgaa      840

actgagtatg agtacagtgg gagtgaggaa gaagaggagg aagtgcctga acaggaagga      900

gagccaagtt ccattgtgaa cgtgcctggt gagtctactc ttcgccgaga tttcctgaga      960

ctgcagcagg agaacaagga acgttccgag gctcttcgga gacaacagtt actacaggag     1020

caacagctcc gggagcagga agaatataaa aggcaactgc tggcagagag acagaagcgg     1080

attgagcagc agaaagaaca gaggcgacgg ctagaagagc aacaaaggag agagcgggaa     1140

gctagaaggc agcaggaacg tgaacagcga aggagagaac aagaagaaaa gaggcgtcta     1200

gaggagttgg agagaaggcg caaagaagaa gaggagagga gacgggcaga agaagaaaag     1260

aggagagttg aaagagaaca ggagtatatc aggcgacagc tagaagagga gcagcggcac     1320

ttggaagtcc ttcagcagca gctgctccag gagcaggcca tgttactgca tgaccatagg     1380

aggccgcacc cgcagcactc gcagcagccg ccaccaccgc agcaggaaag gagcaagcca     1440

agcttccatg ctcccgagcc caaagcccac tacgagcctg ctgaccgagc gcgagaggtg     1500

gaagatagat ttaggaaaac taaccacagc tcccctgaag cccagtctaa gcagacaggc     1560

agagtattgg agccaccagt gccttcccga tcagagtctt tttccaatgg caactccgag     1620

tctgtgcatc ccgccctgca gagaccagcg gagccacagg ttcctgtgag aacaacatct     1680

cgctcccctg ttctgtcccg tcgagattcc ccactgcagg gcagtgggca gcagaatagc     1740

caggcaggac agagaaactc caccagtatt gagcccaggc ttctgtggga gagagtggag     1800

aagctggtgc ccagacctgg cagtggcagc tcctcagggt ccagcaactc aggatcccag     1860

cccgggtctc accctgggtc tcagagtggc tccggggaac gcttcagagt gagatcatca     1920

tccaagtctg aaggctctcc atctcagcgc ctggaaaatg cagtgaaaaa acctgaagat     1980

aaaaaggaag ttttcagacc cctcaagcct gctgatctga ccgcactggc caaagagctt     2040

cgagcagtgg aagatgtacg gccacctcac aaagtaacgg actactcctc atccagtgag     2100

gagtcgggga cgacggatga ggaggacgac gatgtggagc aggaaggggc tgacgagtcc     2160

acctcaggac cagaggacac cagagcagcg tcatctctga atttgagcaa tggtgaaacg     2220

gaatctgtga aaaccatgat tgtccatgat gatgtagaaa gtgagccggc catgacccca     2280

tccaaggagg gcactctaat cgtccgccag actcagtccg ctagtagcac actccagaaa     2340

cacaaatctt cctcctcctt tacacctttt atagacccca gattactaca gatttctcca     2400

tctagcggaa caacagtgac atctgtggtg ggattttcct gtgatgggat gagaccagaa     2460

gccataaggc aagatcctac ccggaaaggc tcagtggtca atgtgaatcc taccaacact     2520

aggccacaga gtgacacccc ggagattcgt aaatacaaga agaggtttaa ctctgagatt     2580

ctgtgtgctg ccttatgggg agtgaatttg ctagtgggta cagagagtgg cctgatgctg     2640

ctggacagaa gtggccaagg gaaggtctat cctcttatca accgaagacg atttcaacaa     2700

atggacgtac ttgagggctt gaatgtcttg gtgacaatat ctggcaaaaa ggataagtta     2760

cgtgtctact atttgtcctg gttaagaaat aaaatacttc acaatgatcc agaagttgag     2820

aagaagcagg gatggacaac cgtaggggat ttggaaggat gtgtacatta taaagttgta     2880

aaatatgaaa gaatcaaatt tctggtgatt gctttgaaga gttctgtgga agtctatgcg     2940

tgggcaccaa agccatatca caaatttatg gcctttaagt catttggaga attggtacat     3000

aagccattac tggtggatct cactgttgag gaaggccaga ggttgaaagt gatctatgga     3060

tcctgtgctg gattccatgc tgttgatgtg gattcaggat cagtctatga catttatcta     3120

ccaacacata tccagtgtag catcaaaccc catgcaatca tcatcctccc caatacagat     3180

ggaatggagc ttctggtgtg ctatgaagat gagggggttt atgtaaacac atatggaagg     3240

atcaccaagg atgtagttct acagtgggga gagatgccta catcagtagc atatattcga     3300

tccaatcaga caatgggctg gggagagaag gccatagaga tccgatctgt ggaaactggt     3360

cacttggatg gtgtgttcat gcacaaaagg gctcaaagac taaaattctt gtgtgaacgc     3420

aatgacaagg tgttctttgc ctctgttcgg tctggtggca gcagtcaggt ttatttcatg     3480

accttaggca ggacttctct tctgagctgg tagaagcagt gtgatccagg gattactggc     3540

ctccagagtc ttcaagatcc tgagaacttg gaattccttg taactggagc tcggagctgc     3600

accgagggca accaggacag ctgtgtgtgc agacctcatg tgttgggttc tctcccctcc     3660

ttcctgttcc tcttatatac cagtttatcc ccattctttt tttttttctt actccaaaat     3720

aaatcaaggc tgcaatgcag ctggtgctgt tcagattcta ccatcaggtg ctataagtgt     3780

ttgggattga gcatcatact ggaaagcaaa cacctttcct ccagctccag aattccttgt     3840

ctctgaatga ctctgtcttg tgggtgtctg acagtggcga cgatgaacat gccgttggtt     3900

ttattggcag tgggcacaag gaggtgagaa gtggtggtaa aaggagcgga gtgctgaagc     3960

agagagcaga tttaatatag taacattaac agtgtattta attgacattt cttttttgta     4020

atgtgacgat atgtggacaa agaagaagat gcaggtttaa gaagttaata tttataaaat     4080

gtgaaagaca cagttactag gataactttt ttgtgggtgg ggcttgggag atggggtggg     4140

gtgggttaag gggtcccatt ttgtttcttt ggatttgggg tgggggtcct ggccaagaac     4200

tcagtcattt ttctgtgtac caggttgcct aaatcatgtg cagatggttc t              4251


<210> 2821
<211> 1805
<212> DNA
<213> Homo sapiens

<400> 2821
gtcattatcc atcgagtcct tgagaaacag gaagttgaag tgttctaccc agactttgga       60

aatattggaa ttgttcagaa gtcctccctg aggttcctca agtgctgcta cacaaagctt      120

ccagctcagg ctatcccttg ttctttggct tgggtgagac cagtagagga acactggaca      180

tcgaaagcta ttttgcagtt ccagaagttg tgcggtttga agccattagt gggggtagtg      240

gatgaatatg tagatggaat ccttaacatt tttttgtgtg acacatcctc aaacgaagat      300

gtctatttcc atcatgtctt gagaacagag ggccatgcta ttgtatgccg agaaaatatc      360

tcttctaagg gtttcagtga gctcaaccct ttagctttat acacgacatc cagtggaggg      420

ccagaggaca ttgtcttgac agaactgggt tatccttccc agcagcacta ttttaatgaa      480

gaccgaaaga taagtccaca gtcaaaagag agtgagttac gtatcttgca agatattaat      540

gatgaaaagt ctttaagtca tcttaaatct gagtcaaagg agccattaaa ggattctgaa      600

tttgagtctt tgaaaacctg taataagagc tttgaagaag atccaaagtg gtccaaccca      660

gaaccaaacg atctgaagga agaaaatgag gatgagatcc ccactggaat gccatgcctg      720

gagtcagtga ccataggtga tgatatttgg gatgagaact ggttacctct acaggctaag      780

atgggaaaag gaggtgatgc tgcctcccat ctatttactg caagccttgg tggaaagaat      840

cagtattcat catgtaaaga aatgccacag aaggactggt gtttttctac ccctaaagat      900

acatgggatg attcttggca gccttcaggc cttgtaaatg gaacgaaagt agaagttcat      960

aagccagaag tactgggtgc tcaggaaaaa aatactggca caaacaggac tcaaaagcaa     1020

ctagacataa atggttcttc agattcttcc acactgccca aattggaaga attctgtacc     1080

tctcttaccc agtcagagca gtcagcagac gggagccagt ctgaacccaa caacagtcag     1140

actcagccaa agcaaattca gctttccaca gcagcaccct gttcaacaac tgcagtggat     1200

gattccgcag aaaagccctc tggttctgtg gaaagctcac cagagatcct aaagaatgaa     1260

gatttttcta gcagccgtgc tattacattg tacaaagaca agcgtcaaga atctgtagac     1320

cagctgtctt tgattttgtc ttatgagtgc cagatttctc agaagctcta cattcctcga     1380

agtacagcca ctgctgcctt aggtgctgcc gcacggttag ctacatccag gagcctccta     1440

cactggtacc ccagtgtgaa aaggatggaa gcatgaggga gggagggagg agggagaaaa     1500

acagaatcca gccgcttagg ctttgatgaa ctcccaggcc aaaatgagga gttattgaag     1560

caaaatagta tcttgatcat tgatactttt gtctttctgt gactatatgt tagctttatt     1620

atgctaacag tctactttga tgtgtaagta agtattgata tttactgtta atcttgattt     1680

ttcttgattt tattctgtgt cattttgttc acctttgttt ttaatgtagt ttaaaggaat     1740

ttgttttttt gtgtttgttt ttcttgtaca ttatcatgac tgataaatga aaattgaaaa     1800

actaa                                                                 1805


<210> 2822
<211> 560
<212> DNA
<213> Homo sapiens

<400> 2822
agcaccggac ttggagtcag agagacctgg ctgcgaatcc cggctccgcc actttctagc       60

gctgtgacct tggcacaaca gctccagctg gcagcatcac ttcccgccaa tttatccaac      120

ttctgccaag gctctgaaat gccaacaacg tcgaggcctg cacttgatgt caagggtggc      180

acctcacctg cgaaggagga tgccaaccaa gagatgagct ccgtggccta ctccaacctt      240

gcggtgaaag atcgcaaagc agtggccatt ctgcactacc ctggggtagc ctcaaatgga      300

accaaggcca gtggggctcc cactagttcc tcgggatctc caataggctc tcctacaacc      360

acccctccca ctaaaccccc atccttcaac ctgcaccccg cccctcactt gctggctagt      420

atgcacctgc agaaacttaa tagccagtat caggggatgg ctgctgccac tccaggccaa      480

cccggggagg caggacccct gcaaaactgg gactttgggg cccaggcggg aggggcagaa      540

tcactctctc cttctgctgg                                                  560


<210> 2823
<211> 3007
<212> DNA
<213> Homo sapiens

<400> 2823
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg tggatggcca gggtacctgg     1200

ggactcaggc tgctgccagt tctgctcacc accatccgtg cttggcacag aagtagctgc     1260

atagaaaggg cactggattt gaagtcagaa gacctgggtt cttgaaccag cctgtcaacc     1320

agttgtatga ctttaaacaa ggcatctcac ctcttttcat cttgttttct tccaataatg     1380

ttagagttca tgtaatcaca ttctctagaa ccatttagtt tgtgttaact atgaaccaag     1440

cagtgtggtg gccactggtg acttgaaaat atagagaaaa aaaaaacctg ctctatatct     1500

gaaagagctc ttgggaagac agagaaacat aaagaggaaa ttacagcaca gtgtggtggg     1560

tgttacggga agtccaaccc cagcattatg ggagttcagg ggaaggggca tagcccagcc     1620

tggaaggaga gggtgagtgg gggatggctt tctgaaaagg gtggtctaaa ggatgcctat     1680

ggtcaatagg gaaaagaggg gaagaagcat cttaagaaga ggaaacagca gagaactggc     1740

tggatgacct gtgactctgg agcactgggt tgtctccatt gtcattatgg gcagatgtgt     1800

gccatcccca gccgacgcca ctcactgcct ccttcctcct ggtgttgcca cttctgggtg     1860

agattaaggt gcagggcctg ggggcaggag gacataaggt atagccataa atcataaccc     1920

agggaccaca ctcaacccta gggaaattgt cttcctgatc agttgattac catctgaggt     1980

caagaaatga gatagtggga gcaaatgggt cacaaatagc tcagctgtgg gctcagaaac     2040

tgctaggtaa aagaattcca gaaggaggcc agggcataag ttggatgacc tatgaacttt     2100

agtctaaaga attgagacta ccgtaattga gactactgta gtgacatctg agaaatggga     2160

tggaagagtg accatgtttt attttcttgt tcttgtcact attgtatttt attttgcata     2220

atcatgccct tcactgacag tctccttaac atcatctgtt tactctgctc agtgtaaact     2280

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2340

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2400

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     2460

gagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     2520

aaaatacaga cacacacaag tgcctatata atgataaaac atatccaaag cacccaaacc     2580

tgtgattcca gaaaagtaga tcctattttt gtttattttt attggcttta gctgtgtctt     2640

ttgaaaggac tattatcctc taaaatgtat gtgtatgaag atcctggctt gcagctcggg     2700

agctttacac accttgtgtc actttatctt ggtaacgagc caagatcatg caaccagttc     2760

atccatgtct gacccaagag ctcttaactg ctatgctgca ctgcctcatt cagagataga     2820

tgcctgcatg ggtcctggcg attattttaa tgctggctac acccccacag gtgacttgga     2880

ttcagaaata caatttatat ttcttctttt taaattgttt tattttattt ttcttttaat     2940

agttatatgt cagtgagaac aatttatatg tcttacactg agaaataaaa ctgctcataa     3000

gtgaaaa                                                               3007


<210> 2824
<211> 1703
<212> DNA
<213> Homo sapiens

<400> 2824
cgtggtgcag cgcatatttt cacaagtggg tctcccttgt ccgggactat ggccaccgac       60

tcgtgggccc tggcggtgga cgagcaggaa gcggctgtca agtcgatgac caatttgcag      120

atcaaggaag agaaagtcaa agcagatacc aatggtatta tcaaaaccag taccactgcc      180

gagaaaacag atgaagagga gaaagaggac agagctgccc agtccttact caacaagctg      240

atcagaagca accttgttga taacacaaac caagtggaag tcctgcaacg ggatccaaac      300

tcccctctgt actcggtgaa gtcgtttgaa gagcttcggc tcccacagaa tctgattgcc      360

cagtctcagt ctggcactgg taaaacagct gcctttgtct tagccatgct cagccgagtg      420

gagccatcag acagataccc ccagtgtctg tgcctctccc caacatatga gctggcgctt      480

caaacaggaa aagtgattga gcagatgggc aaattttacc cagaactgaa gcttgcctat      540

gccgttcgag gcaataaatt ggaaagaggc cagaagatca gtgagcagat tgtcattggc      600

acccctggga ccgtgctgga ctggtgctcc aagctcaagt tcattgatcc caagaaaatc      660

aaggtgtttg ttctggatga ggctgatgtc atgatagcca ctcagggcca ccaagatcag      720

agcatccgca tccagaggat gctgcccagg aactgccaga tgctgctttt ctccgccacc      780

tttgaagact ctgtgtggaa gtttgcccag aaagtggtcc cagacccaaa tgttatcaaa      840

ctgaagcgtg aggaagagac cctggatacc atcaagcagt actatgtcct gtgcagcagc      900

agagacgaga agttccaggc cttgtgtaac ctctacgggg ccatcaccat tgctcaagcc      960

atgatcttct gccatactcg caaaacagct agttggctgg cagcagagct ctcaaaagaa     1020

ggccaccagg tggctctgct gagtggggag atgatggtgg agcagagggc tgcggtgatt     1080

gagcgcttcc gagagggcaa agagaaggtt ttggtgacca ccaacgtgtg tgcccgcggc     1140

attgatgttg aacaagtgtc tgtcgtcatc aactttgatc ttcccgtgga caaggacggg     1200

aatcctgaca atgagaccta cctgcaccgg atcgggcgca cgggccgctt tggcaagagg     1260

ggcctggcag tgaacatggt ggacagcaag cacagcatga acatcctgaa cagaatccag     1320

gagcatttta ataagaagat agaaagattg gacacagatg atttggacga gattgagaaa     1380

atagccaact gagaagctcc accagccact gatgccagcc ctggcactgc ccctgcacag     1440

gagacaagtg catttagggc acaggccccg acatcacccc aaggacaacg gcagaagtag     1500

agagaaacta cctacctcac ttcaaattat gtttggactt gacaaaaata ggtgcaaatg     1560

atggggggca atagaagaaa aaatttgcat tttggaaaat tgggtccttt ccccactttt     1620

ttaaagccac attcccccat ctttataata atctggtcac agtggtagtc gctggcccca     1680

ggaccccctc ctgattttgg cta                                             1703


<210> 2825
<211> 2731
<212> DNA
<213> Homo sapiens

<400> 2825
agcctgcgct tcggaagcat ggatgtgcgc ctgcgctgcg ctagggcgcg gcgggcggtt       60

tgaattttgc ttacagagtc ccgtctcacc atcctgggct tccaacggag actgcggtat      120

ccgcagctgg agacccagcg gcgagtagcc ttttgctccc ggacggactt gagaggctta      180

aaggatggcc tcgtcagatc tggaacaatt atgctctcat gttaatgaaa agattggcaa      240

tattaagaaa accttatcat taagaaactg tggccaggaa cctaccttga aaactgtatt      300

aaataaaata ggagatgaga tcattgtaat aaatgaactt ctaaataaat tggaattgga      360

aattcagtat caagaacaaa ccaacaattc actcaaggaa ctctgtgaat ctcttgaaga      420

agattacaaa gacatagaac atcttaaaga aaacgttcct tcccatttgc ctcaagtaac      480

agtaacccag agctggtaca tgaaatcccg cttaacctat aatcaaatta atgatgttat      540

taaagaaatc aacaaggcag taattagtaa atataaaatc ctacatcagc caaaaaagtc      600

tatgaattct gtgaccagaa atctctatca cagatttatt gatgaagaaa cgaaggatac      660

caaaggtcgt tattttatag tggaagctga cataaaggag ttcacaactt tgaaagctga      720

caagaagttt cacgtgttac tgaatatttt acgacactgc cggaggctat cagaggtccg      780

agggggagga cttactcgtt atgttataac ctgagtccct tgtgaacttt tgaacatacc      840

aacagggtat agagtataga ggctatttct ataattttct tatatataat ttttttaact      900

tttaatcttt tttgtttcct tttttttttt tttgagacag gatcttgctt tgtcacccag      960

gggcttgctt tgtcacgcag gctagagtgc agtggcgcaa acatggctca ctgcagcctc     1020

aacctcccag gctcaagtga tcctcccacc tcagccccct gaatggctgg gactacaagc     1080

gtgcgccacc atgcctggct aatttttgta ttttttggag agatggggtt tcaccatgtt     1140

gcctaggctg gtcttgagct cctgagctca aacaatccac cctcctcagc ctcccaaagt     1200

gctgggatta caggcttgag ccaccacacc tgacctattc ttgtttctta taaaaataaa     1260

acttttttgg ataaagctta tttcttgttt ttttcttttt cttttttttt ttttttgaga     1320

cagtctcgct ctttcaccca ggccggactg cagcggcgct atctcggctc actgcaaact     1380

ctgcctccca ggttcacgcc atcctcctgc ctcagcctcc tgagtagctg ggactacagg     1440

cacctgccac cacgcccagc taattttttg tatttttagt agagatgggg tttcaccgtg     1500

ttagccagga tggtctcgat ctcctgacct catgatccgc ccacctcggc ctcccaaagt     1560

gctgggatta caggcgtgag ccaccgcgcc cggccaactt atatattttc aagattcacc     1620

tcctctcacc aaatatttaa ctacctgctg aatacgcctc tgtactaggc acataatgga     1680

actaaaaaat gctcatgtcc agtttttgtg ttgagtgaac aatgctgcag accctaataa     1740

gattgggtac agatcggcat gcgcctgtag tcccagctac tcaggagaat tgcttgaacc     1800

taggaggtgg aggttgcagt gagccgagat cgtgccactg cactccagtc tgggcaacag     1860

agcgagactc catctcagaa aaaaagaaaa aaagactggg tacagatgtg atattggaag     1920

aaaaagatca agctgatgag gttaggatac ccaggccctt tggacttaaa gatcactagt     1980

gtctaaattc catcgatggc atttcagtct ataggtaaac ttcctggaag ctggatttgg     2040

agacagttta tcatctgatt attgggcttt cgtataggtc cttagggagc agcttacctg     2100

aaatgcattt agtgtacacc agtctgtaaa cttcaacctg taatgaaagt gtaataaatg     2160

tacattgagt tgatgtgata atgtgatata ataagaaata tatatttgat cttcctatct     2220

agttccttgt tcagagctcc taaaaccctt gtaatttcca aagtgatgga gtacatcttt     2280

tgttctagta tttggtcttt gaccccagtt cctgacacaa agctcctaaa ttcctttaaa     2340

tttcccagtg ataggagaat tttttgttct aatgaggtca ctcttgatgg gcacctggat     2400

aactcaggat gggggctgct cacaaagacc acatcatgat tggaagtttc aaactttcag     2460

tctcccacct ccagagaggg gagaggggct ggagatttgt gtcaataatc catcaggcct     2520

atgtcaacaa gacataatcc gttaactatg gagttcaggg agcttcaggg ttggcaaaca     2580

ttttgatgtg ccaggaaggt gacgcactcc agctttatga agtcagcaag tcctgtgctc     2640

aggatgcttc tggaccttgc cccaggtacc ccttcatgtg gctgttgttc atctgtatcc     2700

tttgtagtag ccttaaaata aactgttaaa c                                    2731


<210> 2826
<211> 2163
<212> DNA
<213> Homo sapiens

<400> 2826
agttgccgct gtcgtccgca gagccagttc ctagcgcaga gccgcgcccg ccatgaggga       60

gatcgtgcac atccaggcgg gccagtgcgg gaaccagatc ggcaccaagg tgggcctggc      120

gcggtgcagg gcctctccgc gggtcggctg ctggcgggcc ccgggtctcc cggcgcgacc      180

cccgccgggg cgcgcacccg ctgtgcgccc ctgggtcctc ggagcccggt gcggacccgc      240

gagggccgca gggagggagc gcccggggcg tggccggccg gggaccttct actcttcgct      300

ccccaccccc atcccaactg ggagcggctg ccggcggctc aggcgcgcct ggaattcggc      360

cgccggggcg cctggggtgg gcgcgggtgg cggcgtcccg ggctctgggt tctgagcgtc      420

tgtccccccg ccttgccctg cccaagtttt gggaagtgat cagcgatgag cacggcatcg      480

acccggccgg aggctacgtg ggagactcgg cgctgcagct ggagagaatc aacgtctact      540

acaatgagtc atcgtctcag aaatatgtgc ccagggccgc cctggtggac ttagagccag      600

gcaccatgga cagcgtgcgg tctgggcctt ttgggcagct tttccggcct gacaacttca      660

tctttggcca gacgggtgca gggaacaact gggcgaaagg gcactacacg gagggcgcgg      720

agctggtgga cgcagtgctg gacgtggtgc ggaaggagtg cgagcactgc gactgcctgc      780

agggcttcca gctcacgcac tcgctgggcg gcggcacggg ctcaggcatg ggcacgctgc      840

tcatcagcaa gatccgtgag gagttcccgg accgcatcat gaacaccttc agcgtcatgc      900

cctcgcccaa ggtgtcggac acggtggtgg agccctacaa tgccacactg tcggtgcacc      960

agctggtgga gaatacagac gagacctact gcatcgacaa cgaggcgctc tatgacatct     1020

gcttccgcac tctgaagctg acaacgccca cctacgggga cctcaaccac ctggtgtccg     1080

ccaccatgag tggggtcacc acctcgctgc gcttcccggg ccagctcaat gctgacctgc     1140

gcaagctggc ggtgaacatg gtgcccttcc cgcgcctgca cttcttcatg cctggcttcg     1200

cgccgctcac cagccgcggc agccagcagt accgggccct gaccgtgccc gagctcaccc     1260

agcagatgtt cgacgccagg aacatgatgg ccgcctgcga tccgcgccat ggccgctacc     1320

tgaccgtggc caccgtgttc cgcgggccca tgtccatgaa ggaggtggac gagcagatgc     1380

tggccatcca gagtaagaac agcagctact tcgtggagtg gattcccaac aacgtgaagg     1440

tggccgtgtg cgacatcccg ccccgcggcc tgaagatggc ctccaccttc atcggcaaca     1500

gcacggccat ccaggagctg ttcaagcgca tctccgagca gttctcagcc atgttccggc     1560

gcaaggcctt cctgcactgg ttcacgggtg agggcatgga tgaaatggag ttcaccgagg     1620

cggagagcaa catgaacgac ctggtatccg agtaccagca gtaccaggat gccaccgcca     1680

atgacgggga ggaagctttt gaggatgagg aagaggagat cgatggatag tcggaataga     1740

gccgccccaa ctcagatcct acaacacgca agttccttct tgaaccctgg tgcctcctac     1800

cctatggccc tgaatggtgc actggtttaa ttgtgttggt gtcggcccct cacaaatgca     1860

gccaagtcat gtaattagtc atctggaaca aagactaaaa acagcagaga attgcgggtt     1920

ctacccagtc agaagatcac accatggaga ctttctacta gaggacttga aagagaactg     1980

aggggccaca aaataaactt caccttccat taagtgttca agcatgtctg caaattagga     2040

gggagttaga aacagtcttt ttcatccttt gtgatgaagc ctgaaattgt gccgtgttgc     2100

cttatatgaa tatgcagtat gggactttga aataatgatt cataataaaa tactaaacgt     2160

gtg                                                                   2163


<210> 2827
<211> 2738
<212> DNA
<213> Homo sapiens

<400> 2827
gtagaagagg ggaggaaaca agccagtgca aggggagcaa aagagaaaag gagccaggct       60

gggcttcctg atcccacagc atcgcagagc tcgggaggca cagctcacag acacaggaaa      120

cacaggactg ctattctgct ctcctgccca cggtgatctg gtgccagctg gtggaacagt      180

gggtgatggc gtccctgctg caagaccagc tgaccactga tcaggacttg ctgctgatgc      240

aggaaggcat gccgatgcgc aaggtgaggt ccaaaagctg gaagaagcta agatacttca      300

gacttcagaa tgacggcatg acagtctggc atgcacggca ggccaggggc agtgccaagc      360

ccagcttctc aatctctgat gtggagacaa tacgtaatgg ccatgattcc gagttgctgc      420

gtagcctggc agaggagctc cccctggagc agggcttcac cattgtcttc catggccgcc      480

gctccaacct ggacctgatg gccaacagtg ttgaggaggc ccagatatgg atgcgagggc      540

tccagctgtt ggtggatctt gtcaccagca tggaccatca ggagcgcctg gaccaatggc      600

tgagcgattg gtttcaacgt ggagacaaaa atcaggatgg taagatgagt ttccaagaag      660

ttcagcggtt attgcaccta atgaatgtgg aaatggacca agaatatgcc ttcagtcttt      720

ttcaggcagc agacacgtcc cagtctggaa ccctggaagg agaagaattc gtacagttct      780

ataaggcatt gactaaacgt gctgaggtgc aggaactgtt tgaaagtttt tcagctgatg      840

ggcagaagct gactctgctg gaatttttgg atttcctcca agaggagcag aaggagagag      900

actgcacctc tgagcttgct ctggaactca ttgaccgcta tgaaccttca gacagtggca      960

aactgcggca tgtgctgagt atggatggct tcctcagcta cctctgctct aaggatggag     1020

acatcttcaa cccagcctgc ctccccatct atcaggatat gactcaaccc ctgaaccact     1080

acttcatctg ctcttctcat aacacctacc tagtggggga ccagctttgt ggccagagca     1140

gcgtcgaggg atatatacgg gccctgaagc gggggtgccg ctgcgtggag gtggatgtat     1200

gggatggacc tagcggggaa cctgtcgttt accacggaca caccctgacc tcccgcatcc     1260

tgttcaaaga tgtcgtggcc acagtagcac agtatgcctt ccagacatca gactacccag     1320

tcatcttgtc cctggagacc cactgcagct gggagcagca gcagaccatg gcccgtcatc     1380

tgactgagat cctgggggag cagctgctga gcaccacctt ggatggggtg ctgcccactc     1440

agctgccctc gcctgaggag cttcggagga agatcctggt gaaggggaag aagttaacac     1500

ttgaggaaga cctggaatat gaggaagagg aagcagaacc tgagttggaa gagtcagaat     1560

tggcgctgga gtcccagttt gagactgagc ctgagcccca ggagcagaac cttcagaata     1620

aggacaaaaa gaagaaatcc aagcccatct tgtgtccagc cctctcttcc ctggttatct     1680

acttgaagtc tgtctcattc cgcagcttca cacattcaaa ggagcactac cacttctacg     1740

agatatcatc tttctctgaa accaaggcca agcgcctcat caaggaggct ggcaatgagt     1800

ttgtgcagca caatacttgg cagttaagcc gtgtgtatcc cagcggcctg aggacagact     1860

cttccaacta caacccccag gaactctgga atgcaggctg ccagatggtg gccatgaata     1920

tgcagactgc agggcttgaa atggacatct gtgatgggca tttccgccag aatggcggct     1980

gtggctatgt gctgaagcca gacttcctgc gtgatatcca gagttctttc caccctgaga     2040

agcccatcag ccctttcaaa gcccagactc tcttaatcca ggtgatcagc ggtcagcaac     2100

tccccaaagt ggacaagacc aaagaggggt ccattgtgga tccactggtg aaagtgcaga     2160

tctttggcgt tcgtctagac acagcacggc aggagaccaa ctatgtggag aacaatggtt     2220

ttaatccata ctgggggcag acactatgtt tccgggtgct ggtgcctgaa cttgccatgc     2280

tgcgttttgt ggtaatggat tatgactgga aatcccgaaa tgactttatt ggtcagtaca     2340

ccctgccttg gacctgcatg caacaaggtt accgccacat tcacctgctg tccaaagatg     2400

gcatcagcct ccgcccagct tccatctttg tgtatatctg catccaggaa ggcctggagg     2460

gggatgagtc ctgaggttgc aactagaaat tcagaggggc ttggaataga gaaacctaaa     2520

gaagcatcat cccctccatc cccaacttcc tcaaagccca aagccaaggg aaggataaat     2580

caaggctcaa ggcttcccca gcaaagatta gggaaagaga cttgacccca ggactgtact     2640

acgactctta agagaacact gcacagcact caaagtcccc cactggactg cttcctcctt     2700

agccccactg gtataaatac atctctctcc aatttggc                             2738


<210> 2828
<211> 1567
<212> DNA
<213> Homo sapiens

<400> 2828
cgccgccgtc gccgccgctc ctcctctccc ggtcctgggt ttccttggcg ctgcggccgc       60

cgctccctct gcgacctgta tgaggaggag gaggaggagg atgtgaagat ggcggagctg      120

cagatgctgc tggaagagga aatcccgggg ggccgccggg ccctcttcga cagctacaca      180

aatctggaac gggtggccga ttactgcgag aacaactaca tacagtcagc agataagcag      240

agagccctag aagaaaccaa agcctacacc acccaatcct tagcaagtgt tgcctatctg      300

ataaacacct tggccaacaa tgtcctgcag atgctggata tccaggcatc ccagctacga      360

aggatggaat cttcaatcaa tcatatttca caaacagttg atattcataa agagaaagtt      420

gcaagaagag aaattggtat tttgactacc aataaaaaca cttcaaggac acataagatt      480

attgctccag ccaaccttga acgaccagtt cgttatatta gaaaacctat tgactataca      540

attctagatg atattggaca tggagtaaag tggttgctta gatttaaggt gagtacccag      600

aacatgaaga tgggtgggct gccgcgtaca acacctccaa ctcagaagcc ccctagtccc      660

cctatgtcag ggaaagggac acttgggcgg cactccccct atcgcacact ggagccagtg      720

cgtcctccag tggtaccaaa tgattacgta cctagcccaa cccgtaatat ggctccctcg      780

cagcagagcc ctgtgaggac agcttctgtg aatcaaagaa atcgaactta cagcagcagt      840

gggagtagtg gagggagcca cccaagtagt cggagcagca gtcgagagaa cagtggaagt      900

ggtagtgtgg gggttcctat tgctgttcct actccatctc ctcccagtgt ctttccagcc      960

cctgctggct ctgctggcac tcctcccctt cctgctactt ctgcatctgc ccctgctcct     1020

cttgttcctg ctactgtccc ttcctccact gccccagacg ctgctgctgg gggtgcccag     1080

acccttgctg atggcttcac ttctccaact ccccctgttg tttcttccac tccccctaca     1140

ggtcatcctg tacagttcta cagcatgaat aggcctgcct ctcgccatac tcccccaaca     1200

atagggggct cgttgcccta tagacgccct ccttccatta cttcacaaac aagccttcag     1260

aatcagatga atggaggacc tttttatagc cagaatccag tttcagatac accacctcca     1320

ccgccacctg tggaagaacc agtctttgat gagtctcccc cacctcctcc tcctccagaa     1380

gattacgaag aggaggaagc tgctgtggtt gagtatagtg atccttatgc tgaagaggac     1440

ccaccgtggg ctccacgttc ttacttggaa aaggttgtgg caatttatga ctatacaaaa     1500

gacaaggaag atgagctgtc ctttcaggaa ggagccatta tttatgtcat caagaagaat     1560

gacgatg                                                               1567


<210> 2829
<211> 2352
<212> DNA
<213> Homo sapiens

<400> 2829
caggagaggt agccgaggga gcctgacggg tgacgccagc ggccacgggg ccccgaacga       60

gcaggacatg aggggcgact aggcgcgagg acgagcaaaa gcaagtggat gacagcatga      120

acggccctgc ggggctggcc ggacggctgc aagaacatgc tgagcccaaa gatcaggcag      180

gccaggaggg cccgctccaa aagcctagtg atgggggagc agagccggag ccctgggcgg      240

atgccgtgcc ctcacaggct gggccccgtg ctgaaggcgg gctggctgaa gaagcagagg      300

agcatcatga agaactggca gcagcgctgg tttgtgctgc gtggggatca gcttttctac      360

tacaaggaca aagatgagat caagccccag ggatttattt ctctacaagg gacacaggtg      420

actgaacttc ctcctggccc cgaggaccca gggaagcacc tctttgagat cagcccaggt      480

ggtgccgggg agcgggagaa ggtgccggcc aaccccgagg cgctcctgct catggccagc      540

tcccagcgtg acatggagga ctgggtgcag gccatccgcc gagtcatctg ggccccgctg      600

ggcggaggta ctgcccgtag atcgcatgcc caccctctag aacccttgcc tccagggatc      660

tttgggcagc gcctagagga aacagtccac cacgagcgga agtatggccc ccgcctggcg      720

cccctgctgg tggagcagtg tgtggacttc atccgggagc gcgggctcac tgaggagggg      780

ctgttccgca tgccaggcca ggccaacctg gtgagggacc tgcaggattc cttcgactgt      840

ggggagaagc cactgtttga cagcacaaca gacgtgcaca cggtggcctc cctgctgaag      900

ctgtacctgc gggagctccc cgagcccgtg gtccccttcg ccaggtacga ggacttcctc      960

agctgcgccc agctgctcac caaggacgag ggggagggca ctctggagtt ggctaaacaa     1020

gtgagcaacc ttcctcaggc aaattacaac ctgctcagat acatctgcaa gtttctggat     1080

gaagttcagg catactcaaa tgtcaacaag atgagtgtcc agaatctggc aaccgttttt     1140

ggacctaaca ttctgcggcc acaggtagag gacccagtaa ccatcatgga aggcacttcc     1200

ctcgtccagc acctgatgac cgtcctcatc cgcaaacaca gccagctctt cacggcaccg     1260

gtcccggaag ggcccacctc cccgcgcggg ggcctgcaat gcgcagtggg gtggggctcc     1320

gaggaggtca ccagggacag ccaaggagag cccggcggcc ccggcctgcc cgcgcacagg     1380

acctcttccc tggacggggc ggccgtggcg gtgctctcca gaacagcccc cacggggccg     1440

gggagccggt gcagccctgg gaagaaggtg cagaccctgc ccagttggaa gtcctccttc     1500

cggcagccga ggtccctatc gggaagcccg aaggggggcg gctcatccct ggaggtgccc     1560

atcatctcct ccggcgggaa ctggcttatg aacgggctgt cctccctgcg cggacaccgc     1620

cgggcctcgt cgggagaccg gctcaaggac tcgggctccg tgcagagact ctccacctac     1680

gacaatgtgc ccgcgccggg cctggtcccc ggcataccca gcgtggccag tatggcgtgg     1740

tccggggcct cgtccagcga gtcgtcggtg gggggctcac tcagcagctg cacggcctgc     1800

cgcgccagcg actcgtctgc ccgcagttcc ctgcacaccg actgggccct ggagccctcc     1860

ccgctcccca gcagcagcga ggaccccaag tccctggacc tggaccacag catggacgag     1920

gcgggcgcgg gtgccagcaa cagcgagccc agcgagccgg acagccccac ccgggaacac     1980

gcgcgccgct ccgaggcctt acaggggctg gtcactgagc tcagggccga gctgtgccgc     2040

cagcggactg agtacgagag gagtgtgaaa agaatcgaag aagggagtgc tgacctgaga     2100

aaacgaatgt cccggttaga agaagaactg gaccaggaaa agaaaaaata catcatgctg     2160

gaaataaagc tgcggaactc tgaacgggcg cgggaggatg cggagaggag gaaccagctg     2220

ttgcagaggg aaatggagga gtttttttcg accctaggaa gcttgactgt tggggcaaaa     2280

ggtgccaggg ccccaaagta aaaggaatgg cagagctcac ttctgtacca cgtctgctgg     2340

tctccagcct tg                                                         2352


<210> 2830
<211> 567
<212> DNA
<213> Homo sapiens

<400> 2830
aggctaggcg tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg       60

ccccgcaggc ccaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc      120

ggaatttccc acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg      180

atcccagcat gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg      240

aggaggctgc agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg      300

tttctgaagg agaactagat cagttggctc agattcggcc attaatattc aattttcatg      360

agcagacagc catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata      420

tcatgcagga atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga      480

atcaaccaag caacagagaa aaaaatagat accgagatat tcttccattt caacatcatg      540

gatatagtgg cccaaatgag agaacaa                                          567


<210> 2831
<211> 3086
<212> DNA
<213> Homo sapiens

<400> 2831
aggttgacga tgtgtcacac tgtgtaaggg aatcgcatgg agatgggcat tccgaactgt       60

taatggggac atgggactcc agttgtctct gatcacttgt gtggattttc ctggcgtaga      120

acgacagaag ccgctagtaa gtcgccaaga cctacagcag gaattctgca ccaaagggca      180

taaaatcttg ttattttaat ttgcatctgg gagaatgtct gagcaaggag acctgaatca      240

ggcaatagca gaggaaggag ggactgagca ggagacggcc actccagaga acggcattgt      300

taaatcagaa agtctggatg aagaggagaa actggaactg cagaggcggc tggaggctca      360

gaatcaagaa agaagaaaat ccaagtcagg agcaggaaaa ggtaaactga ctcgcagcct      420

tgctgtctgt gaggaatctt ctgccagacc aggaggtgaa agtcttcagg atcaggaatc      480

aattcattta cagctttcca gtttttccag cctgcaagag gaggataaat ctaggaaaga      540

tgactctgaa agagaaaaag aaaaggataa aaacaaagat aaaacctctg aaaaacccaa      600

gatcagaatg ttatcaaaag attgcagcca agaatacacg gattctacag gcatagactt      660

acacgagttt ctgattaaca cattaaagaa taattccagg gacaggatga tacttttgaa      720

aatggagcag gaaattattg atttcattgc tgacaacaat aatcattata aaaagttccc      780

tcagatgtca tcgtatcaga ggatgcttgt ccatcgagtg gcagcttatt ttggattgga      840

tcacaatgtg gatcaaacag gaaaatctgt tatcatcaac aagaccagca gcaccagaat      900

accagagcaa aggttttgtg aacatttaaa agatgaaaaa ggtgaagaat cccagaagcg      960

gtttatcttg aagcgagata actctagtat tgataaagaa gacaatcagt cagtttgctc     1020

ccaggaaagc ctttttgtgg aaaacagtag gctcttggaa gacagtaaca tatgcaatga     1080

gacctataag aaaagacagc tctttcgggg caacagagat ggctcaggga gaacatctgg     1140

gagtcgacag agcagctcag aaaatgaact caagtggtct gaccaccaaa gggcctggag     1200

cagcacagac tccgacagtt ccaaccgcaa tctaaagccc gccatgacca agacggcgag     1260

ttttgggggc atcacggtgc tgaccagggg tgacagcact tccagtacta ggagtaccgg     1320

gaagctgtcc aaagcaggtt ccgagtcttc cagcagtgca ggctcctcag gatcgctgtc     1380

ccgcacccat ccacctctcc agagcacacc cctagtctca ggtgtggcag ctggctctcc     1440

aggctgtgtg ccttatccag agaatggaat agggggccag gttgctccca gcagcaccag     1500

ctacatcctc cttccacttg aagctgcaac aggcatcccg cctggaagca tccttcttaa     1560

tccacacaca ggccagccct ttgtgaatcc cgatggaact cctgcaatat acaacccacc     1620

caccagtcag cagcccctgc gaagcgccat ggtggggcag tcccaacagc agccaccaca     1680

gcagcagccc tccccgcagc cccaacagca ggtccagcca ccgcagccac agatggcagg     1740

ccctctggtc actcagtctg tccaggggct gcaggcttcc tcccagtcag tgcaatatcc     1800

agcagtctct tttcctcccc agcacctcct acctgtgtct ccaacgcagc actttcccat     1860

gagagatgat gtggcaacac agtttggcca gatgaccctg agccggcagt cctcggggga     1920

gactcctgaa cccccatcag gtcctgtcta cccatcctcc cttatgccac agccggccca     1980

gcagcccagc tatgtaatcg cctctacagg ccagcagctt cctacaggag gattctcagg     2040

ctctggccct cccatctccc agcaggtcct ccagccccct ccctcaccac agggatttgt     2100

gcaacagcct ccgcctgcac agatgcctgt atattattac ccatctggtc agtaccctac     2160

ctcaaccacg caacagtacc ggcccatggc cccggttcag tacaacgctc agaggagtca     2220

acagatgcca caggcagcac agcaagcagg ttaccagcca gtcttgtctg gtcaacaggg     2280

attccaaggc ctaataggag tgcagcagcc acctcagagt cagaacgtga taaataacca     2340

acaaggaact ccggtgcaaa gcgtgatggt ttcctaccca acaatgtctt cttatcaggt     2400

gccaatgacc cagggttctc aaggactgcc ccagcagtca taccaacagc caatcatgct     2460

acctaaccag gcaggtcaag ggtcactccc agccactgga atgcctgttt actgtaatgt     2520

cacaccgccc acccctcaga acaaccttag gctgattggc ccacactgcc cctccagcac     2580

tgtcccagtg atgtcagcta gctgcagaac aaactgtgca agtatgagca atgctggttg     2640

gcaggtcaaa ttctgagagc tctggctgtg gtacatttct tcagatattt ctcatggcct     2700

ttgatggaag aggaacaagg tgggaaaact ggctgaggac ttaagtattc actcaacact     2760

caaatgattg ctgctggtat tctgtaaaaa ataaacaaag actaatatac acgttagctg     2820

gttaatggtg catatttctg tcatgtctgc taggtatgcc tttatagctt agctagtgac     2880

atgaattcat caaggtaaga ttttctccta ccactgaata ccactgtgta gattataata     2940

tccctaattt ggattagttt tgtactttgt gttgagtttg tgatgctaaa agtatttaaa     3000

aattatatac taaatcacat tgtaccaaag ctgtaatgga aaagcaaaga agaattgatg     3060

aattgaagga ataatttata tacatt                                          3086


<210> 2832
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 2832
cctgctcgtt cctgacagaa ttaacggcac agccaacaag atgaacggag ctttggatca       60

ctcagaccaa ccagacccag atgccattaa gatgtttgtc ggacagatcc cccggtcatg      120

gtcggaaaag gagctgaaag aactttttga gccttacgga gccgtctacc agatcaacgt      180

cctccgggac cggagtcaga accctccgca gagtaaaggt tgttgtttcg taacatttta      240

tacaagaaaa gctgcacttg aggcccagaa tgcactgcac aatattaaaa ctttacctgg      300

gatgcatcat cccattcaga tgaaacctgc agatagtgaa aagtccaacg ctgtggaaga      360

cagaaaattg ttcataggaa tggtatcgaa gaaatgtaat gagaacgaca tcagggtgat      420

gttctctcca tttggccaga tagaagaatg ccggatcctc cggggacctg atgggctgag      480

tcgaggctgt gcgtttgtca cattttctac aagggcaatg gcacagaatg caatcaaagc      540

catgcatcag tctcagacca tggagggctg ctcttcacct atcgtggtga agtttgctga      600

cactcagaag gacaaagagc aaaggcgcct ccagcagcag ctcgctcagc agatgcagca      660

gctcaacact gccacctggg ggaacctgac agggctgggc ggactgaccc cacagtatct      720

ggcgctcctg cagcaggcca cctcctccag caacctgggt gcgttcagcg gcattcaaca      780

aatggcaggc atgaatgctt tacagttgca gaacctggcg acgctggctg ctgctgcagc      840

tgcggcccag acctcagcca ccagcaccaa tgcaaaccct ctctctacca cgagcagcgc      900

cctgggagcc ctcacgagtc ccgtggctgc ttcaaccccc aactccactg ctggtgcagc      960

catgaactcc ttgacctctc tcgggactct gcaaggactg gctggagcca ctgttggact     1020

gaataatatt aatgcactag caggtaccat caacagtatg gcggctctga atggaggact     1080

tggcgccaca ggcttgacga atggcacggc tggcaccatg gacgccctca cccaggccta     1140

ctcaggaatt caacagtacg cagccgccgc gctgcccact ctgtacagcc agagcctgct     1200

gcagcagcag agcgctgcag gcagccagaa ggaaggtcca gagggggcaa acctctttat     1260

ttaccacctt ccacaggaat ttggagacca ggacattctg cagatgttca tgccttttgg     1320

aaatgttatc tctgctaaag tcttcattga caaacagacc aatctgagca agtgctttgg     1380

ttttgttagc tacgacaatc cagtctctgc acaagctgct atccaagcta tgaatggctt     1440

tcagatcggc atgaaacgct tgaaggtgca gctgaagcgt tccaaaaacg acagcaaacc     1500

ttactgatcc taaccccaga ggctccctgc tctcatttta gctttcttag gacatcttca     1560

tgcccgttag ttcatcgttt gcctagcatg tccctgtggc gtctcaaaaa aaagtttcat     1620

cgtcccgtca ttgtttctga tgtctttctg acctcacatc atatttggtt ctcctactga     1680

cctttgatct agtttgacct ttgaaatttg catgtgacct catctagcta tgaattctgg     1740

gaagtcaatg tgaaaaacat tgctgcattc atgcaagact gaaatttatt attagacaaa     1800

ttcattatag aaaaaacctg tggcaaaaac gtttctttct tatttttttt cttttcctaa     1860

aacagacttg aaagtattat acagggattg gcattcttcc cggtcactgg taacaatagc     1920

aatatgtgtc cagggacaca gaatgttggt ttctaacaga ctacttccaa aaacagtttg     1980

agaaaaaaac tgtctgattt taagtctcta gaggtctgta atagttttta catttttcag     2040

gcagtgtaaa gttttttgat aaggccattt taggtggctc actttctcat taagatatat     2100

atatagaacc actttttgta gattagtata agaaaaatat ttaccctgtt ttggggcaaa     2160

tgctacctat ttgtgtcacc ttttgctgaa ctcacagtta gacaatccat ggtttaatgc     2220

acatgaaatt acctatattt tatactgttt caatgtacag gagaaaggtt actgtaaact     2280

gtgttatgtt ggtgcttctg tgaattaagt tgtggtttca tcatgagtct taatgttctt     2340

tgttgataag acaagtttag aattggttta cttaatac                             2378


<210> 2833
<211> 603
<212> DNA
<213> Homo sapiens

<400> 2833
gtgcaggagc gggacccgga acagaccgcc gtgagagagg aggggtgccg gccgggattc       60

gcggcccgga gctcgggacc ggagaagaag tcctcaccag tgaacggaga cctctctgaa      120

ctaaggatac catggccacg tcagccccac tacggagcct ggaagaggag gtgacctgct      180

ccatctgtct tgattacctg cgggaccctg tgaccattga ctgtggccac gtcttctgcc      240

gcagctgcac cacagacgtc cgccccatct cagggagccg ccccgtctgc ccactctgca      300

agaagccttt taagaaggag aacatccgac ccgtgtggca actggccagc ctggtggaga      360

acattgagcg gctgaaggtg gacaagggca ggcagccggg agaggtgacc cgggagcagc      420

aggatgcaaa gttgtgcgag cgacaccgag agaagctgca ctactactgt gaggacgacg      480

ggaagctgct gtgcgtgatg tgccgggagt cccgggagca caggccccac acggccgtcc      540

tcatggagaa ggccgcccag ccccacaggg aaaaaatcct gaaccacctg agtaccctaa      600

gga                                                                    603


<210> 2834
<211> 650
<212> DNA
<213> Homo sapiens

<400> 2834
gtctcccggc cacggttgaa accagacgtg cagtggggct gacccctgtg ccccacccca       60

gagtcatgcc agcgtgggtg gtggggcatt ctctgggatg aatgatctgg atcccatagc      120

catctgtgtc ctgtttgagg aatgggaccc tcaaacagag aacagccaag atgctcaagc      180

agtgatttat ctctagggtc tccatagcag gggaggtagg gtcagactcc tgagatggct      240

gatgtcctac cctgccccca accaggggcc ccaggagact cctttttctt actgcaactt      300

tggcctcctc agtctgcaga tctccagggg agcccaccag cctagtcaac atggcctcgg      360

aagacattgc caagctggca gagacacttg ccaagactca ggtggccggg ggacagctga      420

gtttcaaagg caagagcctc aaactcaaca ctgcagaaga tgctaaagat gtgattaaag      480

agattgaaga ctttgacagc ttggaggctc tgcgtctgga aggcaacaca gtgggcgtgg      540

aagcagccag ggtcatcgcc aaggccttag agaagaagtc ggagttgaag cgctgccact      600

ggagtgacat gttcacggga aggctgcgga ccgagatccc accagccctg                 650


<210> 2835
<211> 622
<212> DNA
<213> Homo sapiens

<400> 2835
ctttccagaa gacattccaa ccaccatggt agagtcacag taatgtcatg gagaatgaag       60

ggagtcgggg actaaacaag tggctgcagg tttgtctaca gattttgagc gttcgaagtt      120

gacccctgac taagtatact ttgctgctcc ctcagccttt gaaaaaatgt ctgtcacata      180

tgatgattcc gttggagtag aagtgtccag cgacagcttc tgggaggtcg ggaactacaa      240

gcggactgtg aagcggatcg acgatggcca ccgcctgtgc agcgacctca tgaactgcct      300

gcatgagcgg gcgcgcatcg agaaggcgta tgcgcagcag ctcactgagt gggcccggcg      360

ctggaggcag ctcgtggaga aagggcccca gtacgggacc gtggagaagg cctggatggc      420

cttcatgtcc gaggcagaga gggtgagcga gctgcacctc gaggtgaagg cctcactgat      480

gaacgatgac ttcgagaaga tcaagaactg gcagaaggaa gcctttcaca agcagatgat      540

gggcggcttc aaggagacca aggaagctga ggacggcttt cggaaggcac agaagccctg      600

ggccaagaag ctgaaagagg ta                                               622


<210> 2836
<211> 576
<212> DNA
<213> Homo sapiens

<400> 2836
gtgtcctccg gtcccctctg cctcaggcag ctgcatgttt gcctctgacc tcctcagggc       60

tttagattgc tgccctgggg cgggaagctc cggcctcctc ccccagctgg gcccccgaca      120

gctcctggca ttcacagtga actgtctggg gaatcatcgc tatttggggt tcttcgagga      180

cctggagcag cggcacaagg cccaggtgct ggtcgaggac atcagtgaca tcctggagga      240

gcacgctgag aagcacttcc acccctacat cgcctactgc tccaacgagg tctaccaaca      300

gcgcacgctg cagaagctga taagcagcaa cgccgccttc cgagaggccc tgagagagat      360

tgagaggcgg ccggcgtgcg ggggcctgcc catgctctcc ttcctgatcc tccccatgca      420

gcgggtgacc cggctgcccc tcctgatgga tacgctctgc ctcaagaccc agggccactc      480

cgaaaggtac aaggctgcca gccgtgcact gaaggccatc agcaagctgg tgaggcagtg      540

caacgagggg gcccacagga tggagcgcat ggagca                                576


<210> 2837
<211> 3122
<212> DNA
<213> Homo sapiens

<400> 2837
cttcctaagc cttaaagaga caggacggtc gattggtctg aaattcttga agagacaggc       60

gcccgctccg gccggcacca tggacagcga ggcattccag agcgcgcggg actttctgga      120

catgaacttc cagtcgctgg ccatgaaaca catggatctg aagcagatgg agctggacac      180

ggcggcggcc aaggtggatg aactgaccaa gcagctggag tcgctgtggt cagactctcc      240

cgcgcctcct ggcccgcagg ccggaccccc ttctaggccg ccccggtaca gctccagctc      300

gatccctgag cccttcggca gccgagggtc cccccggaag gcggccaccg acggcgcaga      360

caccccgttc ggacgatcag agagtgcccc aaccctacac ccctacagcc cgctgtcccc      420

caagggacgg ccgtcgtcgc cgcgcacccc gctctacctg cagccggacg cctacggcag      480

cctggaccgc gcgacctcgc cccggccccg cgccttcgat ggcgcaggca gctccctcgg      540

ccgtgcgccc tccccgcggc ccgggccagg cccgctccgc cagcagggtc cccccacgcc      600

tttcgacttc ctgggccgcg caggctcccc ccgcggcagc cccctggcgg aggggcccca      660

ggccttcttc cccgagcgtg ggccgtcacc gcgcccccct gccacagcct acgacgcgcc      720

agcgtccgcc ttcgggagct ccctgctagg ctccggcggc agcgcattcg ccccgcctct      780

gcgcgcgcaa gacgacctga cgctgcgccg gcggcctccg aaagcctgga acgagtctga      840

cctggacgtg gcgtacgaga agaagccttc gcagacagcg agctatgaac gcctggacgt      900

cttcgcaagg cctgcctcgc cgagcctgca gctgttgcct tggagggaga gcagcctgga      960

tggactgggg ggcaccggca aggacaacct cactagcgcc accctgccgc gcaattacaa     1020

ggtctctcct ctggccagcg accggcgttc agacgcgggc agctaccggc gctcgctggg     1080

ctccgcgggg ccgtcgggca ctttgcctcg cagctggcag cccgtcagcc gcatccccat     1140

gcccccctcc agcccccagc cccgcggggc cccgcgccag cgtcccatcc ccctcagcat     1200

gatcttcaag ctgcagaacg ccttctggga gcacggggcc agccgcgcca tgctccctgg     1260

gtcccccctc ttcacccgag cacccccgcc taagctgcag ccccaaccac aaccacagcc     1320

ccagccacaa tcacaaccac agccccagct gcccccacag ccccagaccc aaccccaaac     1380

ccctacccca gccccccagc atccccaaca gacatggccc cctgtgaacg aaggaccccc     1440

caaacccccc accgagctgg agcctgagcc ggagatagag gggctgctga caccagtgct     1500

ggaggctggc gatgtggatg aaggccctgt agcaaggcct ctcagcccca cgaggctgca     1560

gccagcactg ccaccggagg cacagtcggt gcccgagctg gaggaggtgg cacgggtgtt     1620

ggcggaaatt ccccggcccc tcaaacgcag gggctccatg gagcaggccc ctgctgtggc     1680

cctgccccct acccacaaga aacagtacca gcagatcatc agccgcctct tccatcgtca     1740

tggggggcca gggcccgggg ggccggagcc agagctgtcc cccatcactg agggatctga     1800

ggccagggca gggccccctg ctcctgcccc accagctccc attccacccc cggccccgtc     1860

ccagagcagc ccaccagagc agccgcagag catggagatg cgctctgtgc tgcggaaggc     1920

gggctccccg cgcaaggccc gccgcgcgcg cctcaaccct ctggtgctcc tcctggacgc     1980

ggcgctgacc ggggagctgg aggtggtgca gcaggcggtg aaggagatga acgacccgag     2040

ccagcccaac gaggagggca tcactgcctt gcacaacgcc atctgcggcg ccaactactc     2100

tatcgtggat ttcctcatca ccgcgggtgc caatgtcaac tcccccgaca gccacggctg     2160

gacacccttg cactgcgcgg cgtcgtgcaa cgacacagtc atctgcatgg cgctggtgca     2220

gcacggcgct gcaatcttcg ccaccacgct cagcgacggc gccaccgcct tcgagaagtg     2280

cgacccttac cgcgagggtt atgctgactg cgccacctac ctggcagacg tcgagcagag     2340

tatggggctg atgaacagcg gggcagtgta cgctctctgg gactacagcg ccgagttcgg     2400

ggacgagctg tccttccgcg agggcgagtc ggtcaccgtg ctgcggaggg acgggccgga     2460

ggagaccgac tggtggtggg ccgcgctgca cggccaggag ggctacgtgc cgcggaacta     2520

cttcgggctg ttccccaggg tgaagcctca aaggagtaaa gtctagcagg atagaaggag     2580

gtttctgagg ctgacagaaa caagcattcc tgccttccct ccagacctct ccctctgttt     2640

tttgctgcct ttatctgcac ccctcaccct gctggtggtg gtccttgcca ccggttctct     2700

gttctcctgg aagtccaggg aagaaggagg gccccagcct taaatttagt aatctgcctt     2760

agccttggga ggtctgggaa gggctggaaa tcactgggga caggaaacca cttccttttg     2820

ccaaatcaga tcccgtccaa agtgcctccc atgcctacca ccatcatcac atcccccagc     2880

aagccagcca cctgcccagc cgggcctggg atgggccacc acaccactgg atattcctgg     2940

gagtcactgc tgacaccatc tctcccagca gtcttggggt ctgggtggga aacattggtc     3000

tctaccagga tccctgcccc acctctcccc aattaagtgc cttcacacag cactggttta     3060

atgtttataa acaaaataga gaaactttcc ttataaataa aagtagtttg cacagaaatt     3120

ga                                                                    3122


<210> 2838
<211> 6548
<212> DNA
<213> Homo sapiens

<400> 2838
gctcggcccg ggctgccacg agcgtgcggg cctcgccggg catgtcctag gcggcggccc       60

cgcccagcgc tcggccgggc gggcgggcgg gcgcgagggc agggaccgag ccgggccgag      120

ctggggaaca agccggggac caagccgggg accaagccgg ggactaaggc gagccggaga      180

ccgagcccga acagcagtcc cgcagcgtgg acaagcagca tgccgtcatc aactacgacc      240

aggacaggga cgagcactgg gtgaaggacc tgggcagcct caatgggacg tttgtgaatg      300

acatgcgcat cccggaccag aagtacgtca cgctgaagct caacgatgtc atccgcttcg      360

gctacgattc caacatgtat gtgctggagc gtgtgcagca ccgagtcccg gaggaggcac      420

tcaagcatga aaagtacacc agccagctgc aggtgagcgt gaagggtttg gcgcccaaga      480

ggagcgaggc actgccggaa cacacaccat actgcgaggc ctcgaacccc aggccggaga      540

agggggaccg gagaccagga acagaggcag cctcttaccg cacacccctg tatgggcagc      600

cctcctggtg gggtgaggac gatggtagca cgctgcctga cgcccagcgc cagggagagc      660

cctacccaga gcgccccaag ggaccagtgc agcaggacgg ggagctccac ggcttccgcg      720

cccctgctga gcctcagggc tgctcgttcc ggcgggagcc cagctacttc gagatcccca      780

cgaaggagac cccgcagccg tcgcagcccc ccgaggtgcc ggcacacgag atgcccacga      840

aggatgcaga ggcaggtggg ggcggagcgg cccctgtggt gcagagccac gcctccttca      900

ccatcgagtt tgatgactgc agccctggca agatgaagat caaggaccat atcaccaagt      960

tttccctgcg ccagcggcgg cccccgggca aggaggccac acctggcgag atggtgtcgg     1020

ctgagaccaa ggtggccgac tggctggtgc agaatgaccc gagcctgctg caccgggttg     1080

gccctgggga tgaccgccac agcaccaaga gcgacctgcc tgtccacacc cgcaccctga     1140

agggccacaa gcacgaggac ggcacgcaga gtgactcaga ggaccccctg gccaaggcgg     1200

cctcggccgc tggggtgccc ttggaggcca gcggggagca ggtgcggctg cagaggcaga     1260

tcaagcggga cccccaggag ctactacata accagcaggc ctttgtcatc gagttcttcg     1320

acgaggacac accccgaaag aagcgctccc agtccttcac gcacagcccg tccggggacc     1380

ccaaggccga caagcgccgt ggcccaacgc cggccgatag ggaccgcccc agtgtcccag     1440

ccccagtcca ggcagggggc cgcagctcgg ggccacagag ggccggctcg ctcaagcggg     1500

agaagacaga ggaacggctg ggcagcccct cgcccgcctc ccgaacccct gcccgcccct     1560

tcggaagcgt ggggcgccgc tcccgcctgg cccaggactt catggcccag tgtctgcggg     1620

agagctcccc ggccgcccgg cccagccccg agaaggttcc tccggtgctg cccgctcccc     1680

tgacacccca tgggaccagc cccgtgggcc ccccgacccc accgcccgcc cccacggacc     1740

cccagctgac caaggcacgg aaacaggagg aggacgacag cctcagtgac gcagggacat     1800

acaccatcga gaccgaggcg caggacacgg aggtggagga ggcccggaag atgatcgacc     1860

aggtctttgg ggtgttggag tcccctgaac tctccagggc atcttcggcc acctttcgcc     1920

cagtcatcag aggggacaga gatgagtctg atgacggggg cgtggcccag cggatggcgc     1980

tactgcagga gtttgcctcc cggccactgg gtgcggcccc ccaggcggag caccagggcc     2040

tcccggtgcc gggctcccct gggggtcaga agtgggtgtc ccgctgggcc agcctggctg     2100

acagctactc agacccgggc ctcacagagg atggcctggg acgtagaggc ggggagccgg     2160

aggggtccct gcctgtgcgc atgcggcgac ggctccctca gctgcccagt gagagggctg     2220

acagccctgc gggcccagag agcagcagga ggagtgggcc tgggccaccg gagctggaca     2280

gtgagcagcc cagccgcctc ttcggccagg aggagttgga tcctgacagc ctcagcgatg     2340

ccagtgggtc ggacgggggc cgaggccccg agccaggggt ggagccacag gacagcagac     2400

gcaggagccc ccaggagggg cccacgtgga gcaggggtcg gcgctcacca agggcccccg     2460

gggagccaac tcccgcctct ttcttcattg gggaccagaa tggggacgct gtgttatcta     2520

ggaaaccgct tgcggctcca ggggatgggg agggcctagg gcagacagcc cagcccagcc     2580

ccccagcacg ggatggcgtc tatgtcagtg ccaatgggag aatggtcatc cagctacggc     2640

ctggacggtc cccagaaccc gacggccctg ccccagcctt tctccggcaa gagagcttca     2700

ctaaggagcc agccagtggt cccccagcgc ccggcaagcc cccccacatc tccagccacc     2760

cgcttctaca ggacctggcc gctacccggg ccgcacgcat ggacttccac tcccaggaca     2820

cccacctgat cttgaaggag acggagacgg ccctggcggc cctggaggcc cgactcctct     2880

ctaattctgt ggatgccgag tgtgaggggg gcagcacccc gaggccgccg gaggacgccc     2940

tgtctgggga ctcggacgtg gacacagcca gcaccgtcag cctgcgtagt ggcaagagcg     3000

ggcccagccc cacaaccccc cagcctctgc gggcacagaa ggagatgtcg ccatccccgc     3060

cagctgcaca ggacccggga ggcaccgccc tggtcagtgc ccgtgagcag tcctcagaga     3120

ggcagcatca cccacttggc ccgacggaca tgggccgtgg agagccggta cggcgctcag     3180

ccataaggcg tggccacagg ccccgagggt ccctggattg gcccagtgag gagcgtggcc     3240

ctgtcctcgc ccacctaccc agctcagatg tgatggcctc caaccacgaa acccctgagg     3300

ccaccggggc aggacggcta ggttctcgcc ggaaaccagc ggccccaccg ccatccccag     3360

ctgcccggga ggagcagagc cgtagctcag ccagctccca gaaggggccg caggccttga     3420

cccgctccaa cagcctgtcc acccctcgcc ccacacgggc ctcccggctg aggcgggccc     3480

ggctggggga cgcttcagac actgaggctg cggatggtga gcgggggtcc ctgggcaacc     3540

ctgagcccgt gggccggcca gctgctgagc aggccaagaa gctgtcacgc ctggacatcc     3600

tggccatgcc ccggaagcgg gccggctcct tcacagggac tagtgacccc gaggcagccc     3660

ctgcccgcac cagcttctct ggccgcagtg tggagttgtg ctgtgccagc cgcaagccca     3720

ccatggccga agcacgggct gtctccagga aggctgccaa cacagccacc accacgggtc     3780

cccgccagcc cttcagcagg gcccgctcag gcagtgcccg atacacctcc accactcaga     3840

ccccgagggc tggcagctcc agccgggctc gttcccgggc ccccggcccc cgggacacgg     3900

acgacgatga ggaggagcct gacccttatg gtttcatcgt gcagacggca gagattgcgg     3960

agattgccag gctgagccag acgctggtga aggacgtggc catcctagcc caggagatcc     4020

acgatgtggc tggggacggt gacacactgg gctcctcgga gcctgcccac agcgcctccc     4080

tcagcaacat gcccagcacc cccgcctcga ccatctctgc ccgggaggag ctggtgcagc     4140

gcatccccga ggccagcctc aacttccaga aggtgccgcc cggctcgctg aactctcggg     4200

actttgacca gaacatgaac gacagctgtg aggacgccct ggccaacaag acgcggcctc     4260

ggaaccgaga ggaggtgatc ttcgataacc tgatgctgaa cccggtgtcc cagctgtcgc     4320

aggccatccg tgagaacaca gagcaccttg ccgagaagat gaagatcctc tttcagaaca     4380

cagggagagc ttgggaggac ctggaagcca ggatcaacgc cgagaacgag gtgcccatcc     4440

tgaagacatc taacaaggaa atcagctcca tcctgaagga actgaggcgg gtgcagaaac     4500

agctggaagt tatcaatgcc atcgtggacc ccagtgggag cctggacctg ctcacaggaa     4560

acaggagctt ggccagctct gcacagccgg ggctggggaa gggccgcgtg gctgcccaga     4620

gcccaccctc acccgcctca gccgaggccc tgctgccagc cctgcccctg aggaatttcc     4680

cacagcgggc cagctgtggg cctcccagcc tcccggaccc caccttcctc cctgatgccg     4740

agaggttcct gatctaggcc ccagacctgg ccaggccagc ctccctgtgc gtgtgcgtct     4800

ctgccttccg tccgccgcac acccgcctgc ctggccgcag gtggttctcc ctgaagaccc     4860

ccacatgtgc catatccctg tgggcgggtg cctcccacgc ccttgccccc tcgtcagctc     4920

ccagccagca ccctactcac cctgtccagc cccatggcca cccccacccc tgcctcgccc     4980

cctacaggcc tctgggccca gctcctggcc aggctgctgc caaggtcaag ccctcaaggg     5040

cattaccccg cctcctcttc atcactgtta tttttgtctt tagctttaaa ggaaagagtt     5100

gttggtgcca ttgcaggtgc cccctccagg cctgactggc tccgccaggc actaacctgc     5160

cataaccctt tgtgctggcc tgcggccagg cagaggaaga gaggtcgact gtggggtcat     5220

ttggtgccaa acatggaggt gggcaggctc acctgttcct gggactgtct gagatggcag     5280

ggcacttgcc ctggtggctc ccacctgacc ccaggccttt tataggcagg agccccactg     5340

cttccagcct ctggtgccaa cacagttgcc aaacccattg agcttggggc tgccctgtgg     5400

aggcctcctg ggtatggacc aggggcttgt tgagagctga gccatgcaca caggtgcaga     5460

caccccccaa ctcccatgca cacggctagt ccaggcgcct ccacgctgca ccgtgaggac     5520

tgcagggcat gtccccgtga ggggctatgg gcctctgtag gtgggcttcc aaggtcctgg     5580

gtgcagccgg gtgcatggca gcccttctgg cgggggtgag cgcacgacca aagtcactgg     5640

aagccgggtt tccggaagct cgcagcttgg cctgcaccac acgccctccc cttttggctt     5700

cacgccatca ggcctcaagt gggcatgggg gcagggacgg gcccaggaac tgttgttttc     5760

tcaggattct ttcagctggg aacatggcag gtgagcagag cttggtgcct ctgccgtggc     5820

ccctgctggg gcagcccgtg ttgccggagc ctctaagcca aagagcccgt tggccgtggt     5880

tggtgggggt ggacgtgggg gtgtcccacc tggaccagac tggcgtgggt gagctccaca     5940

ccctgcctgg caatggtatg agagtcggac ctggacaggg ccagctgctg ggggagcggc     6000

actggggact ggaggctgga agcgggtggt gtgtgtcccc tgtttacttt tagctgagct     6060

ggggttgggt gtacgggttc tgttcctctg agcctgcggc ccacctgatg tttacgtgtg     6120

tgtgtgaggg ggggcggggg tggcaggtgt ccccccctgg tccccgcccc aagagcctgc     6180

tgtctgtatg gaggaggtgc tagcccggtc caccgggctg ctgcccaccc ctgcatgccc     6240

cagttgccca ccccgcctgc ccctggacat gaagtggtca cgcttcatcc acggctcctt     6300

cccacccctc ggcagtggct gtgcaatgtt ttaagttcac aagttcctgc tcctccccac     6360

actgagctcc tttgttcctc cccctccagc ctttgcctgg gaactggtcc ttgtttgccg     6420

ggcttctcgg agggttcact gtacattcgt tctcaggtgg tcttgtggct gtctttcgga     6480

aaatggttat tttatatgat ttgtcatgga atttgttcta ataaatcatt cttctatcac     6540

atggcagc                                                              6548


<210> 2839
<211> 458
<212> DNA
<213> Homo sapiens

<400> 2839
ctcagtagct tcatctatag tatcagcata acaataattg agcagtttta cctggctcac       60

agcaaggact cggctatggc aaattttatt ttattttaat tattttgttt tatttttatt      120

tgtatcttat tttatttttt gagacgaagt ctcactcttc acccaggctg gagtgcagtg      180

gcacaatctc agctcactgc aacctctgcc tcccaggttc aagcaatcct cccacctcag      240

cctcctgagt agctgggact atagcaagag cctcctgatc tagcagccaa gactccccct      300

gacctttggc catgtacccc aaccctctca tctactgcac ctgctgggac ccctggaact      360

tgggaccacg gaagctaatc aagacccctc aactaccacg caagaactcc acagggagtt      420

ccaagctaac tcctcttgta ccagctccaa aaaatcac                              458


<210> 2840
<211> 1457
<212> DNA
<213> Homo sapiens

<400> 2840
ccagggcgcg gtctggaggc tcacgggaga gaggctgtag ccctgggcaa tcccgggggt       60

cgttacagga aggtaggaaa atgccaccct cagggcactg gttgggctaa aggtgacact      120

ggcgtctcac gggctatgaa gacggaatgc ctcttaatgc cggaattcca agacggaatg      180

cctcttaatg ccgggcaagt ctcacatgaa gctactcatc atttgcttcg tgtcctccga      240

gctccgagag ttggcaaagc tgatgaagga gcagtagaca gcgacccaag cacaccactt      300

cagctaggga aagaccgatt taaggctgca aggaaggagt cctgggagca tggctttccc      360

tgagccaaag ccgcggcctc cagagctgcc gcagaaacgg ttgaagacgc tggactgcgg      420

gcagggggca gtgcgagccg tacgatttaa tgtggatggc aattactgcc tgacgtgcgg      480

cagtgacaag acgctgaagc tgtggaaccc gcttcggggg acgctgctgc ggacgtacag      540

cggccacggc tacgaggtgc tggatgcggc cggctccttt gacaacagta gtctctgctc      600

cggcggcggg gacaaggcgg tggttctgtg ggatgtggca tcagggcagg tcgtgcgcaa      660

attccggggc cacgcaggga aggtgaacac ggtgcagttt aatgaagagg ccacagttat      720

cctgtccggc tctattgatt ccagtatccg ctgttgggat tgccgctcac ggaggcctga      780

gccagtgcag acgctggatg aggccagaga tggcgtgtcc agtgtgaagg tgtcagacca      840

cgagatcctg gcaggctccg tggatggccg cgtgagacgc tatgacctaa ggatggggca      900

gctcttctca gactacgtgg gcagccccat cacctgcacc tgcttcagcc gggatgggca      960

gtgcaccctg gtgtccagcc tggactccac attgcggctc ctggacaaag acacagggga     1020

gctgctgggc gagtacaagg gccataagaa ccaggaatac aagctggact gctgcctgag     1080

cgagcgtgac acacatgtgg tcagctgttc tgaggacggg aaggtgttct tctgggacct     1140

ggtggagggt gcgctggctc tggccctgcc tgtgggttcc ggtgtggtgc agtcgctggc     1200

ctaccaccca acagagccct gcctgctgac cgccatggga ggcagcgtcc agtgctggcg     1260

agaggaggcc tatgaggcag aggatggagc aggctgaagc caggggaccc accaacagga     1320

ccaaggaccg agacacagac atggaaggac ttcagatacc atcttattct agagacgtag     1380

ctgaccaaaa agtaggggag gggctgggtc tgcaaattaa taaatagaag agggggtaag     1440

accttcctgg gaccgca                                                    1457


<210> 2841
<211> 5529
<212> DNA
<213> Homo sapiens

<400> 2841
gatttgggag ttgggaggtg agatgattgg agtgaagaga gttaatgtca tggaaaggaa       60

aagctgtctg aagaaaaata cacattttaa tgtccctctt cagccgtgcc tgctgagagc      120

tctcctggga tgataagtga aagtgtttgg attttttttt aagttttaaa actctgccaa      180

agcattgctc agtgtatctg ggcagcccct tccggcaaaa cgcagcagta gcagaggcag      240

cttctgagag cctgggcagg cagcagctgg ctgaccaagt ccactggaag agaaggcttg      300

tgccagccgg gagaaggaag ccggggacag gatgaaagca acaacacctt tgcagacagt      360

cgaccggccc aaggactggt acaagacgat gtttaagcaa attcacatgg tgcacaagcc      420

gggtctgtac aacccaccct acagtgctca gtcacaccct gctgcaaaga cccaaaccta      480

cagacctctt tccaaaagcc actccgacaa cagccccaat gcctttaagg atgcgtcctc      540

cccagtgcct cccccacatg ttccacctcc agtcccgccg cttcgaccaa gagatcggtc      600

ttcaacagaa aagcatgact gggatcctcc agacagaaaa gtggacacaa gaaaatttcg      660

gtctgagcca aggagtattt ttgaatatga acctggcaag tcatcaattc ttcagcatga      720

aagaccagcc tccttgtatc agtcctctat agacagaagc ctggaaagac ccatgagttc      780

tgcaagcatg gccagtgact tcaggaagcg gaggaagagc gagcctgcag tgggtccacc      840

acggggcttg ggagatcaaa gtgcgagcag gactagccca ggccgagtgg acctcccagg      900

atcaagcacc actcttacaa agtctttcac tagctcttct ccttcttccc catcaagagc      960

aaaaggtggg gatgatagca aaatatgtcc atccctttgc agttactcag ggctcaacgg     1020

caacccctcc agtgagttag attactgtag cacttacaga cagcacttgg atgtccctcg     1080

ggactcacca agagccatta gtttcaagaa cggctggcaa atggcccggc aaaacgcaga     1140

aatctggagc agcacggaag aaaccgtctc tcccaaaatc aaatcccgga gctgtgacga     1200

tctcctaaac gacgactgcg atagcttccc ggacccgaaa gtcaagtcgg aaagcatggg     1260

ctccctgtta tgtgaggagg actccaagga gagctgcccc atggcgtggg ggtcccccta     1320

cgtcccggag gttcgcagta acggcagatc aaggatcaga cacaggtcag cccgcaacgc     1380

cccggggttc ctgaagatgt acaagaaaat gcaccgcatc aaccgcaagg acctgatgaa     1440

ctccgaggtg atctgctccg tgaagtccag gattctgcag tacgagagcg agcagcagca     1500

caaggacctg ctgcgcgcct ggagccagtg ctccacggag gaggtgcccc gggacatggt     1560

gcccacacgc atctccgaat tcgaaaagct gatccagaag tccaaatcca tgccaaattt     1620

aggggatgac atgctgtctc ccgtaaccct agaaccaccg caaaatggcc tatgtcccaa     1680

gaggcggttt tccattgagt atttgctgga ggaagaaaat caaagcggcc cccccgctcg     1740

gggccggcga ggctgccagt ctaacgccct ggtgcccatt cacattgaag tcaccagcga     1800

tgagcagccc cgagcacacg tggagttttc cgacagcgac caggacgggg ttgtgtccga     1860

ccacagtgac tacattcacc tagaggggtc atccttctgc agtgaaagtg actttgatca     1920

cttttccttc acatcctccg aaagctttta cggatccagc caccaccacc accatcacca     1980

ccaccaccac caccgccacc tcatcagctc ctgcaaaggc aggtgcccgg cctcctacac     2040

tcgatttacc acaatgttaa aacacgaaag agccagacac gaaaacaccg aggagcccag     2100

aaggcaagaa atggaccctg gcctttctaa acttgctttt ctagtcagtc ctgtgccttt     2160

ccggaggaaa aaaaattcgg ctcctaagaa acagactgaa aaggcaaaat gtaaagcatc     2220

tgtgtttgag gctctggact ctgcccttaa agacatctgt gaccaaatta aagctgaaaa     2280

gaaaaggggg agcttgccgg acaacagcat cctgcaccgc ctcatcagtg agctgctgcc     2340

agatgttccc gagaggaact catccctgag agcgctgagg aggagccccc tgcaccagcc     2400

tctccaccca ctgcctcccg atggtgctat tcattgtcca ccctaccaga atgactgcgg     2460

gagaatgccc cgcagtgcct ctttccaaga cgtggacaca gccaacagca gctgccacca     2520

ccaagaccgt ggcggtgcac tccaagaccg tgagtcccct agaagttact catccacttt     2580

gactgacatg gggagaagtg caccaaggga aagaagagga actccagaaa aagagaaatt     2640

gcctgcaaaa gctgtttatg attttaaggc tcagacatct aaggagttgt catttaagaa     2700

aggagatact gtctacatcc tcaggaaaat tgatcaaaat tggtatgagg gagaacacca     2760

cgggagagtg ggcatcttcc cgatctcata cgtagagaaa ctcacacctc ctgagaaagc     2820

acagcctgca agaccacctc cgccagccca gcccggagaa atcggagaag ctatagccaa     2880

atacaacttc aacgcagaca caaatgtgga gctgtcactg agaaagggag atagagttat     2940

tcttcttaaa agagttgatc aaaactggta tgaaggtaaa atcccaggaa ccaacagaca     3000

aggcatcttc cctgtttcct atgtggaggt cgtcaagaag aacacaaaag gtgctgagga     3060

ctaccctgac cctccaatac cccacagcta ttctagtgat aggattcaca gcttgagctc     3120

aaataagcca cagcgtcctg tgtttactca tgaaaatatt caaggtgggg gggaaccgtt     3180

tcaggctctg tataactata ctcccaggaa tgaagatgag ctggagctca gagaaagtga     3240

tgtcattgat gtcatggaaa agtgtgatga cggctggttt gtggggacct caagaagaac     3300

caaattcttt ggtactttcc ccggaaacta cgtcaagagg ctgtgaattg cgctccctcc     3360

ttctgtagag gccgcctgcc agccatgcac ctgcgtcaac gcgcctgaaa caccccgcgg     3420

gcctcccgtt gtcatgcctt acggtttcca atgcgccgtc accatctcca cctgccacca     3480

aaccaccagc agagtagccg ccgctgctgt gagcctgggg acgacatggc aggctggtcc     3540

ccctccgtga aagtgtggat tcctacttcc tgctctaagc tttgacacgt caaaatgtgg     3600

gatcagaaag aaaaaaatca tgatatttaa aaatggtcaa atatttgagg caaaaaaaaa     3660

aaaaaaaagt gtctccagga ggctgtccag cctcgtggct ccatttcaac atctcccccc     3720

aggcgatgtt ctcccccaag acgaccagaa aattgtttat tggggaatgc tgtggtttgc     3780

attttcatat tcttcgcttg gcagtgtgta ttcttttcac aagtttgcct agtgtcttgg     3840

tttacacaat atgacaactg taactgtact ttagctattg tttgcctgca catacatgtt     3900

gtaatatgca cagtgattac aacctttaaa gcaagaggag gcgagttaat ttggatgagt     3960

gtgattttgc tgattgaatg tgagttttca aataggagtc tttttctgca atttgtttgc     4020

attttttaga agtgcaaaca gtaagtaaat aaaagccttc ggtaataatc atgacaatac     4080

aagaggctga gctaggctac aggggaaaac tattgtgttg taaagttgca tcgctatttt     4140

atattaaaat gtaatgatca gcatcatgaa caatgagctc ttagtgtttt atttatctga     4200

aaaaatgtaa gtaaaagcag tgttagtgag aggtgcaaag aattattcta acagacacct     4260

gaaagtatct gtaagcaata ctagtaggta agatttcact gtgtgtacac atacacattt     4320

gagattgtat gagaacatat aatccatatg atatgttgta cattttatgg aaatgtaata     4380

gaatctcaca cattatttta tagaaataga gtacagaagc atcacaagta ttaaagttgg     4440

ttttagcaag gattaggatt actacaatta tttttactat aataattatt tttcttctat     4500

ggaactcaga atcctggcta catttgagga caggaatatg ttgagcctga ttttcctggt     4560

gtgtgtaaaa tatttcctag gaataaatta ggcacttttt agaagcaatg ttaaatcatt     4620

caggttttat tttctgccct gaagcagaaa tttaaaaaat gatattggga cctggaaggt     4680

ttaatatggt tcacagtgcc tgaattacac ctgctccgaa aactagcttt gtatttctta     4740

tgactttgca taagaactgt tcatctttgg atcttgagca ccttacagat aaaacttttt     4800

atggcatctc tttcatggac agtgatattg atcttttcac aatgtacgta gcctctagaa     4860

ttttgtacat atgtttgctc tttttttgta cagactagtt gttgagaaaa caggggcgtt     4920

tcctaatttg gtctttatcc tgcgacaaca ctttcagcag actagcctct ccttatctca     4980

cagatcacaa gcacccctag atagtgtgat tctgtcagat agcatttatg caaaaatcta     5040

tgaagttaaa agatcgtaga agccaaatga aatgtacata tctactgact gatgacaagg     5100

gaatttcatt aggaagaagg taaagaaaca tcgttgagta gcctaccttg atttctgtca     5160

agttcataac cagcttcata ttttaaaggc ttcaggtttg aaattaagtc aactgcatgc     5220

agctttgctg ataaatgaat aattctcttt gatgccattt atgagaaaag acttcaatat     5280

ctgttgcctg tcatatttaa gaaaaattac tgtttctact ctctgtatct gattttaaaa     5340

gaaaaaacta ttcatacctg gcttccaggt aattgacttt gaattcttac aagcaaaggt     5400

cattgtgttt ttcttgaata gacatctaat aaattttgct tggaagtata cttcagtttt     5460

tcttcttgac atttatcttt ataaaaattg tgtattttat tccaacttgt taaactaaga     5520

gaaaatgca                                                             5529


<210> 2842
<211> 1107
<212> DNA
<213> Homo sapiens

<400> 2842
cgcggggaaa atggcggcgg cggcggcggc ggctgcagct acgaacggga ccggaggaag       60

cagcgggatg gaggtggatg cagcagtccc cagcgtgatg gcctgcggag tgactgggag      120

tgtttccgtc gctctccatc cccttgtcat tctcaacatc tcagaccact ggatccgcat      180

gcgctcccag gaggggcggc ctgtgcaggt gattggggct ctgattggca agcaggaggg      240

ccgaaatatc gaggtgatga actcctttga gctgctgtcc cacaccgtgg aagagaagat      300

tatcattgac aaggaatatt attacaccaa ggaggagcag tttaaacagg tgttcaagga      360

gctggagttt ctgggttggt ataccacagg ggggccacct gacccctcgg acatccacgt      420

ccataagcag gtgtgtgaga tcatcgagag ccccctcttt ctgaagttga accctatgac      480

caagcacaca gatcttcctg tcagcgtttt tgagtctgtc attgatataa tcaatggaga      540

ggccacaatg ctgtttgctg agctgaccta cactctggcc acagaggaag cggaacgcat      600

tggtgtagac cacgtagccc gaatgacagc aacaggcagt ggagagaact ccactgtggc      660

tgaacacctg atagcacagc acagcgccat caagatgctg cacagccgcg tcaagctcat      720

cttggagtac gtcaaggcct ctgaagcggg agaggtcccc tttaatcatg agatcctgcg      780

ggaggcctat gctctgtgtc actgtctccc ggtgctcagc acagacaagt tcaagacaga      840

tttttatgat caatgcaacg acgtggggct catggcctac ctcggcacca tcaccaaaac      900

gtgcaacacc atgaaccagt ttgtgaacaa gttcaatgtc ctctacgacc gacaaggcat      960

cggcaggaga atgcgcgggc tctttttctg atgagggtac ttgaagggct gatggacagg     1020

ggtcaggcaa ctatcccaaa ggggagggca ctacacttcc ttgagagaaa ccgctgtcat     1080

taataaaagg ggagcagccc ctgagca                                         1107


<210> 2843
<211> 1867
<212> DNA
<213> Homo sapiens

<400> 2843
cttcactgcg caggcgccga gcggccgagg cgccgcggtc ggctctggga ctcgtctggc       60

gtccctcaga ttgctgacag aactggaatc tcctgcttgg tggcccttta gctccaagct      120

ttggaagaca ccaccggaaa caaagcccag ggaagatgtc tccatgacca gttgtgaacc      180

ctttgggaaa gaagggatac tgataaaaat tcctgctgtt atttcccaca gaacagagtc      240

tcacgttaaa ccagggaggc tcaccgtcct tgtgtctggg ttggaaatac atgactccag      300

ttctttgctc atgcacaggt ttgaaagaga agacgtggac gacatcaagg tccactcacc      360

ttacgaaatt agcatccgcc agcggtttat tggaaagcca gacatggcct atcgtttgat      420

atctgccaag atgccagagg ttatccccat tttagaagtg cagttcagca agaagatgga      480

gctgttagaa gatgcattgg tgctcagaag cgcaagaacc tcttcccccg cagagaagag      540

ctgctcagtc tggcatgcag catctgggct gatgggccgt accctgcacc gtgagccacc      600

cgcaggagac caggagggca cagcactgca cctgcagaca agcctgccag ccctttctga      660

ggcagatacc caggaactaa cccagggctt ccggcctatg tcgctgtcaa cccagacagt      720

gttggtgatg ctttgctccg agtctgcagg agctttgtgg agacagagac tttcctagca      780

gggcagcaag cggaagcttt tcttccagaa cagcctttgc tcagggcatg agggagccgg      840

ccaggcccac agcgcccagg gcatcctcct cacggatgtg ttggaggaaa gtggctttgg      900

tgctatcctg ggggaccatg gccataagct ggcagtgtca gccacgcatc agttgcgttt      960

ctttgttcag gttgtgcctc ttgctgcctg cctgagtcac ccagggctgc tccccttcct     1020

ggctctgacg ccctcagcgg gtcccacaag ccgctcagga ccacagagtc tggccatggg     1080

tctggccagg catccactga tgctctaagc tgcagcttct cttaggaaca cttctatcag     1140

gtctggctcg caggcatgcc ccagggccag cctggattgt actgtccttc aagcactcct     1200

tgctctattt ctttgaagtt tataaaagtt tgtttccccc aaaacccaaa gcacttttaa     1260

tcaggtagtt tctgtggagg tcgaactggc tggaaggaag gctggttcct ggatttcttt     1320

actcatgtag cagggactca aggaagtctg atttgcgcct cgcctctgac tcagagccca     1380

tgaaggttcc tgtgtgaggc cactggctgc ctcggagctg acagcatcct gcacaatggc     1440

tagatggctt gtcaccccag gccgcagagg aacaactgtt tctagggttt ggccagactt     1500

cacattctcc attctttcca tccctgttat gtggaatgca cacgatgcca tgtaattact     1560

tcagtccctt ctcaaaggaa aaagaatctg gacctgcact ccaggacact agcagtttga     1620

aggttcgctc aggaatgttc tttgtctgca gacctagcag ctgtacagat cgctcttgtg     1680

tttttgcact attaattaac ttcaagtgca attttggcag gcaggccaag ggtctcaaca     1740

ggctatttgg aatgagttct cttttaaggc cttcaacgta gtgagacatt ttcaaatcaa     1800

aaagtacagc aggagccagc ctttattttg tctgtgtaca caataaaata ttccgcttct     1860

ataggca                                                               1867


<210> 2844
<211> 1890
<212> DNA
<213> Homo sapiens

<400> 2844
gcggaggccc ggcgtgacaa gcggcccaga ctcccgtggg cgccgcacac ctgttgtttg       60

cagcagccag cgacccgcac taccgctctc ggcgggcggg gaagcggccg cagcggagcc      120

gacccggcag gtggccgcgg gcggggccgg cgagcgaaag tgcgcggggg cccgaccacc      180

gcggggccgg gacgcgatgg cggcggcaga gcccgcgagc tcgggccagc aggcgccggc      240

agggcagggg cagggccagc ggccgccgcc gcagcctccg caggcgcaag ccccgcagcc      300

gcccccgccg ccgcagctcg ggggcgccgg gggcggcagc agcaggcacg agaagagcct      360

ggggctgctc actaccaagt tcgtgtcgct gctgcaggag gccaaggacg gcgttctgga      420

tctcaaagcg gctgctgata ctttggctgt gaggcaaaaa aggagaattt atgatatcac      480

caatgtctta gagggaattg acttgattga aaaaaagtca aaaaacagta tccagtggaa      540

aggtgtaggt gctggctgta atactaaaga agtcatagat agattaagat atcttaaagc      600

tgaaattgaa gatctagaac tgaaggaaag agaacttgat cagcagaagt tgtggctaca      660

gcaaagcatc aaaaatgtga tggacgattc cattaataat agattttcct atgtaactca      720

tgaagacatc tgtaattgct ttaatggtga tacacttttg gccattcagg caccttctgg      780

tacacaactg gaggtaccca ttccagaaat gggtcagaat ggacaaaaga aataccagat      840

caatctaaag agtcattcag gacctatcca tgtgctgctt ataaataaag agtcgagttc      900

atctaagccc gtggtttttc ctgttccccc acctgatgac ctcacacagc cttcctccca      960

gtccttgact ccagtgactc cacagaaatc cagcatggca actcaaaatc tgcctgagca     1020

acatgtctct gaaagaagcc aggctctgca gcagacatca gctacagata tatcttcagg     1080

atctattagt ggagatatca ttgatgagtt aatgtcttct gacgtgtttc ctctcttaag     1140

gctttctcct accccggcag atgactacaa ctttaattta gatgataacg aaggagtttg     1200

tgatctgttt gatgtccaga tactaaatta ttagattcca tggaaacttg ggactgttat     1260

ctacctctaa ctgtgtaaca ttttagactt cttaataacc taaatattta aaataatgaa     1320

tgtaacacct tttttagttc actgattctg aagtgttctt ccctaatact ttctttactt     1380

cacaaaactt caaccataaa aacaaagggc tctgattgct ttaggggata agtgatttaa     1440

tatccacaaa cgtccccact cccaaaagta actatattct ggatttcaac ttttcttcta     1500

attgtgaatc cttctgtttt ttcttcttaa ggaggaaagt taaaggacac tacaggtcat     1560

caaaaacaag ttggccaagg actcattact tgtcttatat ttttactgcc actaaactgc     1620

ctgtatttct gtatgtcctt ctatccaaac agacgttcac tgccacttgt aaagtgaagg     1680

atgtaaacga ggatatataa ctgtttcagt gaacagattt tgtgaagtgc cttctgtttt     1740

agcactttaa gtttatcaca ttttgttgac ttctgacatt ccactttcct aggttatagg     1800

aaagatctgt ttatgtagtt tgtttttaaa atgtgccaat gcctgtacat taacaagatt     1860

tttaaaaata aaattgtata aaacattcaa                                      1890


<210> 2845
<211> 261
<212> DNA
<213> Homo sapiens

<400> 2845
gcgcctcggc ccgggcctta ctctccaccg actgcgtcag gatgagctcc aggttttctt       60

tgggccgatg cttcgtgtcc tccaccagct tatagacgcg atgtcgccgg tgcaggcgcg      120

gcttccggcc ctccccggcc agcggtacct tccaccagcg ctccacgatg accgtgccct      180

ggcggccagg aaagcgacgc atcacttata aggaagagga ggacttgaca ctccagcccc      240

gttcctgcct ccagtgctcc t                                                261


<210> 2846
<211> 557
<212> DNA
<213> Homo sapiens

<400> 2846
aatttgaagg gtttcttgta gagagaaatg cacattttga cgtacatttg attcaagtgc       60

agggtgtctt ttatgaataa tcaaaagcag caaaagccaa cgctatcagg ccagcgtttt      120

aaaactagaa aaagagatga aaaagagagg tttgacccta ctcagtttca agactgtatt      180

attcaaggct taactgaaac cggtactgat ttggaagcag tagctaagtt tcttgatgct      240

tctggagcaa aacttgatta ccgtcgatat gcagaaacac tctttgacat tctggtggct      300

ggtggaatgc tggccccagg tggtacactg gcagatgaca tgatgcgtac agatgtctgc      360

gtgtttgcag cccaagaaga tctagagacc atgcaagcat ttgctcaggt ttttaacaag      420

ttaatcaggc gctacaaata cctggagaaa ggttttgaag atgaagtaaa aaagctgctg      480

ctgttcttga agggtttttc agagtcggag aggaacaagc tagctatgtt gactggtgtt      540

cttctggcta atggaac                                                     557


<210> 2847
<211> 565
<212> DNA
<213> Homo sapiens

<400> 2847
gagcggcggt aagtgagccg cggcgggcga gggtgtagtg gggtcttgct gggccggttt       60

tggaggcctg gagtcaaggg gcgagctcgc cagggagggc gagggtcaca gcaagtctca      120

ggatcctcct ctgccagttt ctgggtggtc cttcctcctc cagggactca ctgattccgg      180

ctggcgccct tcgtctgtag ccgcgtcccc tcagactggt tcagtccggg gtcttctgac      240

ttggaagctc gtgctgattt cctaagtcag cccctcctgt cctcttggca agaaataatg      300

gcggcagcta cgggggatcc tggactctct aaactgcagt ttgccccttt tagtagtgcc      360

ttggatgttg ggttttggca tgagttgacc cagaagaagc tgaacgagta tcggctggat      420

gaagctccca aggacattaa gggttattac tacaatggtg actctgctgg gctgccagct      480

cgcttaacat tggagttcag tgcttttgac atgagtgctc ccaccccagc ccgttgctgc      540

ccagctattg gaacactgta taaca                                            565


<210> 2848
<211> 3700
<212> DNA
<213> Homo sapiens

<400> 2848
ggtgaaaacc ggcagaaaga cattaagaga ttttcctgca gtcactgctg gcagatgata       60

gagccaggat ttgaaagcag gcagcctggc tccagaccct gtgctcttaa ctcccgtttt      120

gcatcaagaa cagaatccta tgaaaggctt gcacagtgct tggtactgag taggcactcc      180

gtcagtattt tagtagctat tattccaaag gacactgtat tctaggtact aagacaatgt      240

gaatggaatg gaaaacaatt cctccctgca gaagccaact gtctaggaag acagataatg      300

acattattaa aataatcaga acattggcaa aataaagaag attgaaatgc agttcatatg      360

acagtgctaa ttaatcatac tttttagatc taggaaaggc cataaaggtt aaattgactt      420

ggaaatggta aacaagacaa tggttgtgtc actgatcggt gatggccagt ttttggttat      480

ccttatttgc catttaaatg attgaattga aaggaagaag taagacttgg aagatgaata      540

ttgaaggaaa ggtgaagatg gaaaagagaa gggggtttat tctgagaaca gtgactagaa      600

ctctgaggta tggtagaaat ttcaggataa cagatgataa aggggaatga agccatggag      660

aggaagagaa tgataatatt aattgtgaaa gtttgtgtca agtgttttct gagtcacctt      720

tctttcagtt tctcatttct agtattgtat aaatgagttt aacatcaaaa tggtatagtg      780

aaaaaaagga tgaactgctt gacagaagag gtcagatcta gttttgactc tagcttattt      840

agctttacag ctttaaataa attacagtgt ctttaaagct ctggatctta agttttctaa      900

ttgtttttta aacaaagatt tgtgaacacc tacttacaat gtgacaaatg tctttgtaag      960

gcattatggg agataaaagc tgcattaaac ctggctgttg tacttacaag taatttggaa     1020

ggcaaaattt caaatacttg aacctaaagt agggtttctt ggttttcatt taattgaaat     1080

actgttagga aacaaaaatt tttcataaat ttttcttgtg gatatgtaag taaattctat     1140

atatctagca atatgataca tctatagttc tgtttaaagg taacaatgtg aggaagctta     1200

tgcgaataac ttgacagaag aaatctaaag taaaagcatt ttcctagtag gctagcttgt     1260

tctcttattt catttattgt aacagtttca ctttttaata attatgtgaa attaggaaac     1320

agatattcta gggcattctg tttagggtga tgaacttatt catgaatgtt attaaaacca     1380

tttaaatatg ccatagttta aatttgtgat ccatgctgtt caatctgtga cctaggatag     1440

cagcatcaag gagcattgtg tacatgcaga agtgcacagt acctggagtg aaactgcttg     1500

tgttcgattt ctgataccat tcataactgg ctgtgtgatc tcaaaacctc taaaatgcag     1560

acctccagct ctagatctgt gcacctgagt gaatggcaga agaattactt cgcaattaca     1620

tctggcatat gtaccggacc gaaggcagat gcataccgtg cacagatatt acgcattcag     1680

tatgcatggg caaactctga gatttcccag gtctgtgcta ccaaactgtt caaaaaatat     1740

gcagagaaat attctgcaat tattgattct gacaatgttg aatctgggtt gaataattat     1800

gcagaaaaca ttttaacttt ggcaggatct caacaaacag atagtgacaa gtggcagtct     1860

ggattgtcaa taaataatgt tttcaaaatg agtagtgtac agaagatgat gcaagctggc     1920

aaaaaattca aagactctct gttggaacct gctcttgcat cagtggtaat ccataaggag     1980

gccactgtct ttgatcttcc taaatttagt gtttgtggta gttctcaaga gagtgactca     2040

ttacctaact cagctcatga tcgagaccgg acccaagact tcccggagag caatcgtttg     2100

aaactccttc agaatgccca gccacctatg gtgactaaca ctgctaggac ttgtcctaca     2160

ttctcagcac ctgtaggtga gtcagctact gcaaaattcc atgtcacacc attgtttgga     2220

aatgtcaaaa aggaaaatca cagctctgca aaagaaaaca taggacttaa tgtgttctta     2280

tctaaccagt cttgttttcc tgctgcctgt gaaaatccac agaggaagtc tttttatggt     2340

tctggcacca ttgatgcact ttccaatcca atactgaata aggcttgtag taaaacagaa     2400

gataatggcc caaaggagga tagcagcctg cctacattta aaactgcaaa agaacaatta     2460

tgggtagatc agcaaaaaaa gtaccaccaa cctcagcgtg catcagggtc ttcatatggt     2520

ggtgtaaaaa agtctctagg agctagtaga tcccgaggga tacttggaaa gtttgttcct     2580

cctataccca agcaagatgg gggagagcag aatggaggaa tgcaatgtaa gccttatggg     2640

gcaggaccta cagaaccagc acatccagtt gatgagcgtc tgaagaactt ggagccaaag     2700

atgattgaac ttattatgaa tgagattatg gatcatggac ctccagtaaa ttgggaagat     2760

attgcaggag tagaatttgc taaagccacc ataaaggaaa tagttgtgtg gcccatgttg     2820

aggccagaca tctttactgg tttaagggga ccccctaaag gaattttgct ctttggtcct     2880

cctgggactg gtaaaactct aattggcaag tgcattgcta gtcagtctgg ggcaacattc     2940

tttagcatct ctgcttcatc cttaacttct aaatgggtag gtgaggggga gaaaatggtc     3000

cgtgcattgt ttgctgttgc aaggtgtcag caaccagctg tgatatttat tgacgaaatt     3060

gattccttgt tatctcaacg gggagatggt gagcatgaat cttctagaag gataaaaaca     3120

gaatttttag ttcaattaga tggagcaaca acatcttctg aagatcgtat cctagtggtg     3180

ggagcaacaa atcggccaca agaaattgat gaggctgccc ggagaagatt ggtgaaaagg     3240

ctttatattc ccctcccaga agcttcagcc aggaaacaga tagtaattaa tctaatgtcc     3300

aaagagcagt gttgcctcag tgaagaagaa attgaacaga ttgtacagca gtctgatgcg     3360

ttttcaggag cagacatgac acagctttgc agggaggctt ctcttggtcc tattcgcagt     3420

ttacaaactg ctgacattgc taccataaca ccggatcaag ttcgacccat agcttacatt     3480

gattttgaaa atgcttttag aactgtgcga cctagtgttt ctccaaaaga tttagagctt     3540

tatgaaaact ggaacaaaac ttttggttgt ggaaagtaag tgggatactt ggaatcaagg     3600

catctctgta gtacagtctt ctttattttt tagcatagaa agttggggat gtgttaattg     3660

tatttttaag aatatattct aagttctgta cttcaaataa                           3700


<210> 2849
<211> 2959
<212> DNA
<213> Homo sapiens

<400> 2849
tttgaggccc aagggggagc gagccggtgc tgctgcaggc tgaggctgcg gcagaggcgg       60

cgaggcgcgg gcggtgagga cggacagtca ccgacttagt ccagttccct gtgatctcaa      120

aacaattgtt gcagcaggct cctggcagtc tcaagcagtt catcttcttg gtgtactggt      180

ttcctattgt gattttatca tggaaaatca attggctaaa tcaactgaag aacgaacatt      240

tcagtaccag gattctcttc catcactgcc tgttccttca cttgaagaat cattaaaaaa      300

ataccttgaa tcagtcacca gaacatgcta ccagataagg ggtcttgatc cagatgctaa      360

gagagggttc ttggatctca cgcgggaagg aattcaagtg aaaccatttg caaatcaaga      420

agaatataag aaaactgaag aaatagttca aaaatttcaa agtgggattg gagaaaaatt      480

gcaccagaaa ttgcttgaaa gagcaaaagg aaaaagaaat tggctggaag agtggtggct      540

gaatgttgcc tatctggatg ttcgtatacc atcacaattg aatgtcaact ttgcgggtcc      600

tgcagctcat tttgaacact actggcctcc aaaggaaggg actcaattag aaagaggaag      660

tataactctt tggcataact tgaactactg gcagctatta agaaaagaaa aagtgcctgt      720

tcataaagtt ggaaatactc ctctagatat gaatcaattc cgaatgctat tttctacctg      780

caaggttcca ggaattacta gagactccat tatgaattat tttaggactg agagtgaagg      840

gcgttcccca aaccacattg tagtgctgtg tcgaggccga gcttttgtct ttgatgtaat      900

acatgaagga tgtttggtca ccccgccaga gcttctcaga caactgacat atatccacaa      960

gaagtgccat agtgaacctg atggacctgg gattgcagca ttaactagtg aggagcgaac     1020

tcgatgggct aaggcacgag aatatctgat tggtcttgat ccagagaact tggctttgtt     1080

agaaaaaatt cagagtagtt tactggtata ttccatggag gatagcagtc cacatgtaac     1140

accagaggat tattctgaga ttattgcagc catccttatt ggagatccaa cagtacgctg     1200

gggtgacaaa tcctataact tgatttcctt ttctaatgga gtatttggct gtaattgtga     1260

tcatgctcct tttgatgcaa tgattatggt gaacatcagt tattatgtgg atgagaaaat     1320

ttttcagaat gaaggaagat ggaagggttc agagaaggta cgagatatac cacttccaga     1380

agagctcatt ttcattgtgg atgagaaagt tttaaatgac atcaaccaag ctaaagccca     1440

gtatctcagg gaggcatctg atctacagat tgcggcttat gcctttacat cttttggcaa     1500

aaagctaacc aagaacaaga tgcttcaccc ggatacgttt attcagcttg cacttcagct     1560

ggcctattac agacttcatg gacaccctgg ttgttgctat gaaacagcta tgacaagaca     1620

tttttatcat ggccgtacag agactatgcg atcatgcaca gttgaagcag tgaggtggtg     1680

ccagtccatg caggatcctt ctgtcaatct tcgtgagcgg cagcaaaaga tgttacaagc     1740

ttttgcaaag cataataaaa tgatgaaaga ttgttcagct ggaaaaggat ttgatcgtca     1800

ccttttaggt ctcttactca tagcaaaaga ggaaggtctt cctgttccag aactctttac     1860

ggacccactt ttttccaaaa gcggaggagg tggaaatttt gttctctcaa caagtctggt     1920

tggctattta cgagtccagg gagtggtagt tcccatggta cacaatggtt atggattttt     1980

ctaccatatc agagatgaca ggtttgttgt ggcctgttca gcctggaaat cctgtcccga     2040

gactgatgcg gaaaagctag ttcagctgac tttttgtgct tttcatgata tgatacagct     2100

gatgaactct actcatcttt agagatgaat catctattaa gcacttacca aaacatatca     2160

ttaaactgag tgctgggagt gagttggtaa tatgagatgg gaaggaatgt tgacttgcta     2220

acattccttt aacaagttaa gaaaacttgt taaatgtaga aattagtaga atcatgctct     2280

ctaaatttat tctgccatag aaggtagaaa tatttttaag ctcctctgat gcagcagcaa     2340

tgcaaattat gacatagtga atatagaact atgcagtatt taagcctcaa caatccaaat     2400

ctacaaactt taacaatgca agtcttactc taatttttaa gtatttttgt tggtacttac     2460

atgggttata aatcctctct ctggacatca atgtagagtc catctttcaa gcactttaat     2520

ttttttagct gccaaagggt atgaattaca ttattgtatg ctaatttccc tgaaatcaat     2580

gccttctatg ttcaccacag ggatacaagc ctgttatgtt tgatgggaaa gaccactaca     2640

atctaatggt gatctaaaat aacttttttg ggctgggtgc agtggctcat gcctataatc     2700

ttagcacttt gggaggccaa ggtaggagga ttgcttgaag ctaggagttt gagaccagcc     2760

tgggcaacag ggtaaggtcc tgtctctaca agatcaaaaa cttagccggg tatggtggtg     2820

catgtgtgcc tgtagtccaa gctacttgaa ggctgagaca ggaggatcgg ttgagcccag     2880

gaggttgtgg ctgcagtgag ctgtgatgtg cccttatgct atagcctggg caagagcgtg     2940

agaccctgtc tcaaagaag                                                  2959


<210> 2850
<211> 603
<212> DNA
<213> Homo sapiens

<400> 2850
gtgcaggagc gggacccgga acagaccgcc gtgagagagg aggggtgccg gccgggattc       60

gcggcccgga gctcgggacc ggagaagaag tcctcaccag tgaacggaga cctctctgaa      120

ctaaggatac catggccacg tcagccccac tacggagcct ggaagaggag gtgacctgct      180

ccatctgtct tgattacctg cgggaccctg tgaccattga ctgtggccac gtcttctgcc      240

gcagctgcac cacagacgtc cgccccatct cagggagccg ccccgtctgc ccactctgca      300

agaagccttt taagaaggag aacatccgac ccgtgtggca actggccagc ctggtggaga      360

acattgagcg gctgaaggtg gacaagggca ggcagccggg agaggtgacc cgggagcagc      420

aggatgcaaa gttgtgcgag cgacaccgag agaagctgca ctactactgt gaggacgacg      480

ggaagctgct gtgcgtgatg tgccgggagt cccgggagca caggccccac acggccgtcc      540

tcatggagaa ggccgcccag ccccacaggg aaaaaatcct gaaccacctg agtaccctaa      600

gga                                                                    603


<210> 2851
<211> 2198
<212> DNA
<213> Homo sapiens

<400> 2851
gacaagacat ttcaaagaaa gtattaaatt cattcacgag tgccggctcc gcggtgagag       60

ctgccttgta cactgcctgg ccggggtctc caggagcgtg acactggtga tcgcatacat      120

catgaccgtc actgactttg gctgggagga tgccctgcac accgtgcgtg ctgggagatc      180

ctgtgccaac cccaacgtgg gcttccagag acagctccag gagtttgaga agcatgaggt      240

ccatcagtat cggcagtggc tgaaggaaga atatggagag agccctttgc aggatgcaga      300

agaagccaaa aacattctgg gtaaatataa ggagcaaggg cgcacagagc cccagcccgg      360

cgccaggcgg tggagcagtt ttccggcact ggctccgctg acctacgata attatacgac      420

ggagacctaa cgcaagcgac ctgctgcctt ccttcccact gcttgtcttc agtgtgcccg      480

gctgggcagg ggtgcggtgg tggtggccga tgaggacagg aaagggagat agccagggcg      540

aggtggggcg agggctcctt cccccaagca acaccgccca gccctgctcc aggcccctgc      600

actccgccca cccctaccct ggctgcacct gagcttgctg cccctgggga tgttgcccag      660

tggctgtgca ctgctctgtg cacgtgcgtg tgtgtgagtg cacttgtgtg tgggtgacta      720

agtggatgca tgtgtgtgcc tgtgtgagtg agggtatgtg cacctaagtg tgtacatgtg      780

tgtatgttgt gaaagtgtct gtgcacatga atgtttgtgt gtgtgtgaac tctttcttac      840

tgctggaagt cacagaattc atattgctgc ccgggttggt gtggccacct ttccctttgt      900

ccaagactcc acatggaagg catttgagct cgacctccga aaagctaccc agcaaagagc      960

agtctgtgcc tctgagcaga ccgtgagaac tcaggggacg agtggctaag agcatggcct     1020

ctcccagaac ccacccaggg tggtgtggtg ggggcaacag gggccagact cctctagagg     1080

gagggtggct ctggggccct ggaaaacgtg agagactgcc ctgagctggt ccagtgggcc     1140

agcactttat accaactcag catttaaggg aagtatctta gattgcctcc atctcaatgt     1200

gaatgcacca ggctgagggt tccctagcgc cttgagtcaa ggccactttt cagcccatcg     1260

agccctgagt tctacttggt gtttgttctc tggagctgat tgcacttgag ctctgtggtg     1320

ggcaggcgca ctttagccta agttgggtgc cccagggcac cccctcctct ctgctccttg     1380

ccagcttcat tcactcccag cctctcgctg tcctcacttt gcaggggctc ctcctcaaca     1440

tttgcatgca cctgcaagaa ttgggaagaa agagcattta ttaggcactg tagcaatttg     1500

cattttaaaa tgcctgagca tttattaagc ttcttggtat tcacttgggt ttgataattg     1560

atctgagcta cctcattgaa tgtttttgga aaggtgtttt ttggtatgca agtcagcttt     1620

gcctcacagt tgaaaatgtt cggtcatgat tgcttttgaa accaaagggg aaggtaccga     1680

tatcattgag ctatttaaag ttgccagttt gggctccagt aatgctttct ggtgggtaaa     1740

attccacatt caggccacga gagcatctac agtttgtact ctggggctgc aggcatcctg     1800

ggacgctgta cgcaattcag tggtctagtc ctttataccg actcagattc cttaagcatg     1860

cagagtcact cgaatgaaaa aacatactcg acctctccct aaaaagatgt tgcaacccag     1920

tttctctgaa ttccaccaca aaaagagacc ctgaataaga agagcagttt tcctgtgcat     1980

atagagggtg tgtcaaaggt gagctttttg gggaccggga aaaacaaagt tgcctgattc     2040

cgcgcaggtg cacaggcccc ggatgtacac ccggaaaggg gagtgtggct gtagaatcat     2100

ccatccgtct acagctaaaa caatttgcca ataaagtaca tgtttttcct aagccaaaaa     2160

taaatacgtt aacagaaaaa tgatttagga tatagctt                             2198


<210> 2852
<211> 738
<212> DNA
<213> Homo sapiens

<400> 2852
gccgccatcg ctgtgagccc tgtactatca gccatggtca actccgtcat cttttttgac       60

atcaccgtcg acggcaagcc cttgggccgc atctccatca aacagtttgc agacaagatt      120

ccaaagacag cagaaaactt tcgtgctctg agcactggag agaaaggatt tcgttataag      180

ggttcctgct ttcacagaat tattccaggg tttatgtgtc agggtggtga cttcacacac      240

cctaatggca ccggtgacaa gtccatctat ggggagaaat ttgatgatga gaacctcatc      300

cgaaagcata caggttctgg catcttgtcc atggcaaatg ctggacccaa cacaaatggt      360

tcccagtttt tcatctgcac tgccaagact gagtggttgg atggcaagca tgtggccttt      420

ggcaaggtga aagaacgtgt gaatattgtg gaagccatgg agcactttgg gtacaggaat      480

agcaagacca gcaagaagat caccattgct gactgtggac aattctaatg agtttgactt      540

gtgttttatt ttcaccacca gacccattcc ttctgtagct caggagagca cccctccacc      600

acatttgctt gcaatatcct agaatctttg tgctcttgct gcagttccct ttgggttcca      660

tgttttcctt gttcccttcc atgcctagct ggattgcaga gttaagttta tgattatgaa      720

ataaaaacta agtaacaa                                                    738


<210> 2853
<211> 674
<212> DNA
<213> Homo sapiens

<400> 2853
gaggtggccg ccgctggctc cctgggcccc agcctggttc ccgcgcgggc cgcggctgcc       60

ttccagacgc agggcatgcg acctgttgga gtgtgaaatt ctaggggccg ggttcctccc      120

cagagcggtt ttatttccga ctggactgtg ctgcgggtct cagaggccct ctggtccgtt      180

caggtgcagg cctgagtgtt ccttccagca tgtcggaggg ggagtcccag acagtactta      240

gcagtggctc agacccaaag gtagaatcct catcttcagc tcctggcctg acatcagtgt      300

cacctcctgt gacctccaca acctcagctg cttccccaga ggaagaagaa gaaagtgaag      360

atgagtctga gattttggaa gagtcgccct gtgggcgctg gcagaagagg cgagaagagg      420

tgaatcaacg gaatgtacca ggtattgaca gtgcatacct ggccatggat acagaggaag      480

gtgtagaggt tgtgtggaat gaggtacagt tctctgaacg caagaactac aagctgcagg      540

aggaaaaggt tcgtgctgtg tttgataatc tgattcaatt ggagcatctt aacattgtta      600

agtttcacaa atattgggct gacattaaag agaacaaggc cagggtcatt tttatcacag      660

aatacatgtc atct                                                        674


<210> 2854
<211> 1272
<212> DNA
<213> Homo sapiens

<400> 2854
tgcccctcta ccatgtggcc cttcccgagc cgctctctct tcccaccccc gactcaggcc       60

tggctccaga cggtctcctc agaccctgag gcccagggct ggggggcctg gaacgagacc      120

aaggagattc tggggccaga gggtggggaa gggaaggagg agaaagagga ggaagaggat      180

gcagaggaag accaggatgg ggatgcaggc tttctgctgt ctctgctgga gcaagagaac      240

ctggctgagt gcccattgcc tgaccaggag ctggaggcca tcaagatgaa ggtgtgtgcc      300

atggagcagg ccgaggggac gccacggcct ccaggagtgc agcaacaggc cgaggaagag      360

gagggcaccg cggccgggca gctgctgagc cctgagaccg tgggctgccc cctctctggg      420

acccccgagg agaaggtgga ggctgaccac agatccgtct acgtgggcaa cgtggactac      480

gggggctccg ccgaggagct ggaggcccac ttcagccgct gtggggaggt ccaccgagtc      540

acgatcctgt gtgacaagtt ctctggacac cccaagggtt atgcctacat agagtttgcc      600

accaagggct ccgtgcaggc cgccgtggag ctggaccaga gcctcttccg gggccgggtc      660

atcaaggtgc tgccgaaaag aaccaacttc cctgggatca gctccacaga ccgcgggggc      720

cttcgaggac acccaggctc caggggggca cccttccccc acagcggcct ccagggcagg      780

ccccggctca gaccacaagg gcagaaccgg gcccgtggaa aattctcacc atggttttca      840

ccgtattaaa gggaagaccc gattttgaga gaggggctgg ggcctggatc aggagtaaac      900

cacttgtgct ccatcctggg gctggggcag ggagtggcgc gggggcgagg ccagaggaga      960

ggggtgtcca gagcagccac tggccccctc ttggcggggg gatggcccag tagggccttg     1020

tatggtggtc cagacccaag gccacagcca cgagtcacag ccacggcccg gtggtgagcc     1080

tggcatgggc cccacgggga tctgcggggc tctgggtgtt gagggagggg aggagcagag     1140

tcccaggcag tgccaggcca gcttggggtt ggcatgctca gctcttcaac taagtcattt     1200

taagaaaaat agaaacgtgt gtcttaatgg tgaagcataa attattaaac ttgggctctt     1260

tttaaaagca aa                                                         1272


<210> 2855
<211> 543
<212> DNA
<213> Homo sapiens

<400> 2855
acaatataca aggtagccag aagtgaatat gattgagaat tctcattagt gtgaggagac       60

agtttgaagt ccataaggtt ggaaattgca aattaatcat ttgtatataa gtcagtttaa      120

ttcagatctg ctttgtgaca aggttaggag agaatgtggg gcttaaaggt gatgtcgaca      180

atgaaagcca tttcttctta tggttgacga tgtgtcacac tgtgtaaggg aatcgcatgg      240

agatgggcat tccgaactgt taatggggac atgggactcc agttgtctct gatcacttgt      300

gtggattttc ctggcgtaga acgacagaag ccgctagtaa gtcgccaaga cctacagcag      360

gaattctgca ccaaagggca taaaatcttg ttattttaat ttgcatctgg gagaatgtct      420

gagcaaggag acctgaatca ggcaatagca gaggaaggag ggactgagca ggagacggcc      480

actccagaga acggcattgt taaatcagaa agtctggatg aagaggagaa actggaactg      540

cag                                                                    543


<210> 2856
<211> 966
<212> DNA
<213> Homo sapiens

<400> 2856
agtggtcaag gccgcgctcg cgccgagggg ctgcgagagt gaccgcggct gctccagcgc       60

tgacgccgag ccatggcgga cgaggagctt gaggcgctga ggagacagag gctggccgag      120

ctgcaggcca aacacgggga tcctggtgat gcggcccaac aggaagcaaa gcacagggaa      180

gcagaaatga gaaacagtat cttagcccaa gttctggatc agtcggcccg ggccaggtta      240

agtaacttag cacttgtaaa gcctgaaaaa actaaagcag tagagaatta ccttatacag      300

atggcaagat atggacaact aagtgagaag gtaagcttag acagccttga ggaactttac      360

tgttacctgc tttatcaaaa catggcttca aaaggtcagc tgcatcttca ctggattaca      420

gaattcttgc tgactctcag aagaaattgt tggagagaat agtcatacct actttaaaag      480

agaataaatt gcctttccta aattcctctg cttcgctcct ttcctggcgt tgctctggaa      540

ccttgttggt gtctgtgacc caatgactgt tagggtcagc tagcttcaat tgcccctgca      600

ctggaagcaa ggtttgtcag taacaccaat taaaatacta ccagtgtaag tagaaggtgt      660

gttttgcaga tgagaaggtg ctaagatgcc ttgcttatgt tctctgtgtt gctgtaatac      720

catgaggggt atgttgtggc aaacctggcc tttgagatca agacgaaccc cacctgccct      780

gagaagccgt ctgctaccac cacagcctac ccgaattggt cctgtcccct aaacccctca      840

cactgagaac tgcttgtgtg ggagagagct ggttgggttg atcttttccg agtgtgactt      900

acctccttca aggggatgtt taagcttctc gggcagaagt ggtgtgtcta ttcctgacac      960

caaaca                                                                 966


<210> 2857
<211> 6603
<212> DNA
<213> Homo sapiens

<400> 2857
gccacaggga cagccggtgg gctcggtggg gctgcagaag gtcggggctg cactgctctc       60

ggcccccaca cggttggttg gttggcgtgg taagtgccct gatccctggt cctgagaact      120

caggctggca cagggattcc cagggcatct accaccacgc agctggagca gggctgagcc      180

caggagcatg gagatggacg cccccaggcc ccccagtctt gctgtccctg gagcagcatc      240

gaggcccggg agggctgcca tcagcagcag tgagccatca cctctgctgg ccacattgtg      300

ttttttctcc tagaactgtg gacaacggaa ggctgagccc catccattga gttcctgggg      360

ccccactgga ggggctgctg tggccagggt gcacggtcac aaatgaagac accaaggcgc      420

agagaggtga ctcagcctgc cctcagtcac ctatctgctc ctggaggtga tccccgactc      480

catgaggaag caagaggtgc ggacgggcag ggaggccggc cagggccacg gtacgggctc      540

cccagccgag caggtgaaag ccctcatgga tctgctggct gggaagggca gtcaaggctc      600

ccaggccccg caggccctgg ataggacacc ggatgccccg ctggggccct gcagcaatga      660

ctcaaggata cagaggcacc gcaaggccct gctgagcaag gtgggaggtg gcccggagct      720

gggcggaccc tggcacaggc tggcctccct cctgctggtg gagggcctga cggacctgca      780

gctgagggaa cacgacttca cacaggtgga ggccacccgc gggggcgggc accccgccag      840

gaccgtcgcc ctggaccggc tcttcctgcc tctctcccgg gtgtctgtcc caccccgggt      900

ctccatcact atcggggtgg ccggcatggg caagaccacc ctggtgaggc acttcgtccg      960

cctctgggcc catgggcagg tcggcaagga cttctcgctg gtgctgcctc tgaccttccg     1020

ggatctcaac acccacgaga agctgtgtgc cgaccgactc atctgctcgg tcttcccgca     1080

cgtcggggag cccagcctgg cggtggcagt cccagccagg gccctcctga tcctggacgg     1140

cttggatgag tgcaggacgc ctctggactt ctccaacacc gtggcctgca cggacccaaa     1200

gaaggagatc ccggtggacc acctgatcac caacatcatc cgtggcaacc tctttccgga     1260

agtttccatc tggatcacct cccgtcccag tgcatctggc cagatcccag ggggcctggt     1320

ggaccggatg acggagatcc ggggctttaa cgaggaggag atcaaggtgt gtttggagca     1380

gatgttcccc gaggaccagg cccttctggg ctggatgctg agccaagtgc aggctgacag     1440

ggccctgtac ctgatgtgca ccgtcccagc cttctgcagg ctcacgggga tggcgctagg     1500

ccacctgtgg cgcagcagga cggggcccca ggatgcagag ctgtggcccc cgaggaccct     1560

gtgcgagctc tactcatggt actttaggat ggccctcagc ggggaggggc aggagaaggg     1620

caaggcaagc cctcgcatcg agcaggtggc ccatggtggc cgcaagatgg tggggacatt     1680

gggccgtctg gccttccatg ggctgctcaa gaagaaatac gtgttttacg agcaagacat     1740

gaaggcgttt ggtgtagacc tcgctctgct gcagggcgcc ccgtgcagct gcttcctgca     1800

gagagaggag acgttggcat cgtcagtggc ctactgcttc acccacctgt ccctgcagga     1860

gtttgtggca gccgcgtatt actatggcgc atccaggagg gccatcttcg acctcttcac     1920

tgagagcggc gtatcctggc ccaggctggg cttcctcacg catttcagga gcgcagccca     1980

gcgggccatg caggcagagg acgggaggct ggacgtgttc ctgcgcttcc tctccggcct     2040

cttgtctccg agggtcaatg ccctcctggc cggctccctg ctggcccaag gcgagcacca     2100

ggcctaccgg acccaggtgg ctgagctcct gcagggctgc ctgcgccccg atgccgcagt     2160

ctgtgcacgg gccatcaacg tgttgcactg cctgcatgag ctgcagcaca ccgagctggc     2220

ccgcagcgtg gaggaggcca tggagagcgg ggccctggcc aggctgactg gtcccgcgca     2280

ccgcgctgcc ctggcctacc tcctgcaggt gtccgacgcc tgtgcccagg aggccaacct     2340

gtccctgagc ctcagccagg gcgtccttca gagcctgctg ccccagctgc tctactgccg     2400

gaagctcagg ctggacacca accagttcca ggaccccgtg atggagctgc tgggcagcgt     2460

gctgagtggg aaggactgtc gcattcagaa gatcagcttg gcggagaacc agatcagtaa     2520

caaaggggcc aaagctctgg ccagatccct cttggtcaac agaagtctga cctctctgga     2580

cctccgcggt aactccattg gaccacaagg ggccaaggcg ctggcagacg ctttgaagat     2640

caaccgcacc ctgacctccc tgagggtgaa attcatgtac cataaaattg actgttttag     2700

gcgggtccca gaggctgatg cctgtaatcc cagcactttg ggaggccaag gcaggtggat     2760

cacttgaggt cgggagttcg agaccagcct ggccaacatg cctccagggc aacaccgtta     2820

gggatgatgg tgccaggtcc atggctgagg ccttggcctc caaccggacc ctctccatgc     2880

tgcacctgca gaagaacagc atcgggccca tgggagccca gcggatggca gatgcccttg     2940

aagcagaaca ggagtctgaa agagctcatg ttctccagta atagtattgg tgatggaggt     3000

gccaaggccc tggctgaggc cctgaaggtg aaccagggcc tggagagcct ggacctgcag     3060

agcaattcca tcagtgacgc aggagtggca gcactgatgg gggccctctg caccaaccag     3120

accctcctca gcctcagcct tcgagaaaac tccatcagtc ccgagggagc ccaggccatc     3180

gctcatgccc tctgcgccaa cagcaccctg aagaacctgg acctgacagc caacctcctc     3240

cacgaccagg gtgcccgggc catcgcagtg gcagtgagag aaaaccgcac cctcacctcc     3300

cttcacctgc agtggaactt catccaggcc ggcgctgccc aggccctggg acaagcacta     3360

cagctcaaca ggagcctcac cagcttagat ttacaggaga acgccatcgg ggatgacgga     3420

gcgtgtgcgg tggcccgtgc actgaaggtc aacacagccc tcactgctct ctatctccag     3480

gtggcctcaa ttggtgcttc aggcgcccag gtgctagggg aagccttggc tgtgaacaga     3540

accttggaga ttctcgactt aagaggaaat gccattgggg tggctggagc caaagccctg     3600

gcaaatgctc tgaaggtaaa ctcaagtctc cggagactca atcttcaaga gaattctctg     3660

gggatggacg gggcgatatg cattgccaca gcactgtctg gaaaccacag gctccagcat     3720

atcaatctcc agggaaacca cattggggac tccggggcca ggatgatctc agaggccatc     3780

aagacaaatg ctcccacgtg cactgttgaa atgtgatcct ggtggacgga tcaggagaat     3840

gggcagatgc tcagctggaa gcttttgaac agaaaggccg acttctgggg ggcctgtctg     3900

ggagctggga acgctgcttg ctcagcacga gagccgggct ctgcagggag gaaggagagg     3960

tgctgccgga ggaggtcgtg agctcctctt ctgctgcagg agtggtccag gcagggggtg     4020

acgggtactc tgttatggca cagagaaggg aggggccacc cccaagggac taggggccaa     4080

aggcctgaaa gctgagcagt acaggaggct ggttccagct ttacaccctg aggacttcat     4140

gtgtccccaa cctttaaaaa tgtttattac tgcccctttc cactcacctg gttaaaaatc     4200

atcccatgct ctgagatgag ctgccacctc aagcccgtga ggagcatccg tttggtaggg     4260

gtaacagagg ggacccttct ttatcttctc aagaagaaga tttcagggta tcatccttac     4320

agacatgaaa aagctatggg aaaattgtga agataaatga aagttttaat tctaggattc     4380

tggaaacaga gacagtaaga gttctccaag gattttgcct tttttgtttg tttttgagat     4440

ggagtctcgc tcttgtcgcc caggctggag tgcagtggca cgatctcagc tccctgcaac     4500

ctccgcctcc cgggttcatg tgattctcct gcctcagcct ccccagtagc tgggaataca     4560

ggcacccgcc accatgcccg gctaattttt gtagttttag tagagacggg gtttcatcat     4620

gttggccagg ctggtctcga actcctgacc tcaggtgatc catcagcctg ggcctcccaa     4680

agtactggga ttacaggcat gagccaccac acctggcccc attttttatt tattacaaaa     4740

tcaaagacat gggtgatgcc tggcacatgt tgtctggagt ctggcacact ggttatcaat     4800

agcacattca gtgtattcag tgatgtcatt ctttatttat ttttgagaca gaatctgtca     4860

cccaggctgg agtgcagtgg catgatctca gctcactgta ggctctacct catgggttcc     4920

agtgattctc ctgcctcggc ctcccaagta gttgggtcta caggcacgca ccaccacacc     4980

cagctaattt ttgtattttt agtagagatg gggtttcacc atgttgatca ggctggtctt     5040

taactcctga cctcaagtga tccacccacc tcagcctccc aaagtgctgg gattacaggt     5100

gtgagccact gcacctggca gtgatgtcat tccttactag gcttccaaag ccactgctgt     5160

ggccacagct tccatggaga caggcaagct gagcctctat gtggcaccaa ttcctgcagc     5220

tgtttgtgtt ggagggaaaa aaatccaaat ggacatcaac agctttcatc aactaaataa     5280

ccacagaaaa tatttatgaa gactataaag caatgattac ttttgaattg gaaaggaatc     5340

actattattt gaaatgtttc ttcaaaagtg agcatccgga caggaaccat catggatgct     5400

gaggccatgg atgaaggcct actcgggaag atgatatcct tgcagtctca aaacggcacc     5460

ccacaaaggt gatatcctaa tttacaaagg gaaaaaggta ccttaatctg aaatctggca     5520

aatgcagcct caacagaagt gacagaattg aacatcgcca ataatgggac acacagacat     5580

cacatgcccc cagtctgatg caccacggag tcgtctctga tgtattcttg tcaaaaaatg     5640

tttgcctgat tctaatcatg aaagaacaat tagaaaaaat ccaaattgac agatattctg     5700

cagaataaat ggcctgacct catcaaaaac atcaatgtca tgaaaaacac aaaacattgc     5760

agatagcgtg aaattaaaga ttacagagat ataatttaat gcaagatctc tgactggatc     5820

ctagactgca ggaaaaagtc tgctataaag aacatttgga tcacttgtag tagctgggaa     5880

ataaaacaaa acattatttg taaaaggggg gaaatctgaa catgggtctt gcagtattta     5940

tgacagtttt tgcggggcag agatttctag attgacagct gttttagtac tttcaaggtg     6000

atgctctgtc tgctggtttg cattgtttct gtctgagtta agagactggc agaacacaga     6060

gttgcagtag ccaaacactg gagaaagctg ggccctacag aaacctaacg ctgaagaaac     6120

ctcaggagcc aaactggtgg agaaaacaaa gagtcctccc tctctccctt ttcaaataat     6180

gatcatacat cttcaagctg tctgaaatgg ttaaggagtt cagtctgtcg tcaggcacac     6240

accagagcca gctagcccac acagacccca tcagagcaaa acagacaaga gaatttaatt     6300

catatccaca tagaaaggac ttctaggtag gaggtagacc ctttagctcc cttccaatta     6360

aaggagtccc caattctggc acctgagagt cccctgggtc taacagctat gatatttatg     6420

tagtgtgttg cttacctaaa tgaatacaat ttccttccag acacgtgaca ctgatattaa     6480

agtgctaatg agagggatct atttcttctt gtacgctaaa agagaaacag cagttcagat     6540

ttcccatcag aagtccgagg actttgttct tgataactac taccaataaa aattgagtat     6600

ttg                                                                   6603


<210> 2858
<211> 554
<212> DNA
<213> Homo sapiens

<400> 2858
ggccgggatt cgcggcccgg agctcgggac cggagaagaa gtcctcacca gtgaacggag       60

acctctctga actaaggata ccatggccac gtcagcccca ctacggagcc tggaagagga      120

ggtgacctgc tccatctgtc ttgattacct gcgggaccct gtgaccattg actgtggcca      180

cgtcttctgc cgcagctgca ccacagacgt ccgccccatc tcagggagcc gccccgtctg      240

cccactctgc aagaagcctt ttaagaagga gaacatccga cccgtgtggc aactggccag      300

cctggtggag aacattgagc ggctgaaggt ggacaagggc aggcagccgg gagaggtgac      360

ccgggagcag caggatgcaa agttgtgcga gcgacaccga gagaagctgc actactactg      420

tgaggacgac gggaagctgc tgtgcgtgat gtgccgggag tcccgggagc acaggcccca      480

cacggccgtc ctcatggaga aggccgccca gccccacagg gaaaaaatcc tgaaccacct      540

gagtacccta agga                                                        554


<210> 2859
<211> 4433
<212> DNA
<213> Homo sapiens

<400> 2859
gggatgctga aggtgctgaa atagcaatga caagagactt ggctcagtgt taaataactg       60

ccgcgctggc ctgacagtct ctgagatgac aatagggaga atggagaacg tggaggtctt      120

caccgctgag ggcaaaggaa ggggtctgaa ggccaccaag gagttctggg ctgcagatat      180

catctttgct gagcgggctt attccgcagt ggtttttgac agccttgtta attttgtgtg      240

ccacacctgc ttcaagaggc aggagaagct ccatcgctgt gggcagtgca agtttgccca      300

ttactgcgac cgcacctgcc agaaggatgc ttggctgaac cacaagaatg aatgttcggc      360

catcaagaga tatgggaagg tgcccaatga gaacatcagg ctggcggcgc gcatcatgtg      420

gcgggtggag agagaaggca ccgggctcac ggagggctgc ctggtgtccg tggacgactt      480

gcagaaccac gtggagcact ttggggagga ggagcagaag gacctgcggg tggacgtgga      540

cacattcttg cagtactggc cgccgcagag ccagcagttc agcatgcagt acatctcgca      600

catcttcgga gtgattaact gcaacggttt tactctcagt gatcagagag gcctgcaggc      660

cgtgggcgta ggcatcttcc ccaacctggg cctggtgaac catgactgtt ggcccaactg      720

tactgtcata tttaacaatg gcaatcatga ggcagtgaaa tccatgtttc atacccagat      780

gagaattgag ctccgggccc taggcaagat ctcagaagga gaggagctga ctgtgtccta      840

tattgacttc ctcaacgtta gtgaagaacg caagaggcag ctgaagaagc agtactactt      900

tgactgcaca tgtgaacact gccagaaaaa actgaaggat gacctcttcc tgggggtgaa      960

agacaacccc aagccctctc aggaagtggt gaaggagatg atacaattct ccaaggatac     1020

attggaaaag atagacaagg ctcgttccga gggtttgtat catgaggttg tgaaattatg     1080

ccgggagtgc ctggagaagc aggagccagt gtttgctgac accaacatct acatgctgcg     1140

gatgctgagc attgtttcgg aggtcctttc ctacctccag gcctttgagg aggcctcgtt     1200

ctatgccagg aggatggtgg acggctatat gaagctctac caccccaaca atgcccaact     1260

gggcatggcc gtgatgcggg cagggctgac caactggcat gctggtaaca ttgaggtggg     1320

gcacgggatg atctgcaaag cctatgccat tctcctggtg acacacggac cctcccaccc     1380

catcactaag gacttagagg ccatgcgggt gcagacggag atggagctac gcatgttccg     1440

ccagaacgaa ttcatgtact acaagatgcg cgaggctgcc ctgaacaacc agcccatgca     1500

ggtcatggcc gagcccagca atgagccatc cccagctctg ttccacaaga agcaatgagg     1560

actgcccagt ggaggagggg cgatgtggct ggggagctag ggagagactc tggaggtggt     1620

gggtctctcg ggagacccct aatgaggaag ttgaggtaat gcttaacatt gttgctgtga     1680

gaatttactg ccctatgttt cccagagcca ttttggctca attcaagtct attcaattca     1740

agttaactct agcccagccc agatcaactc ctcctacaaa tattattgga tgataggccc     1800

tagaacccaa taaaggagct ccaaatgtcg ttgggtgggg aagcaaaatg tagagaaaca     1860

tttaaagcac actgtaataa taaatgcaat tataaactat atggaggagg gtgcagagga     1920

gggaatgtgt ctggtgtgtg atgtgtgtgt gtgcagtggg ggtatcacag agagtatgac     1980

atctgagttg agggtagcag gtgcctggag tctcaggtgg ctgctcaccc atctgtgcag     2040

gtgtctctgg ggctgctggt ctcacctgtg gtctgcagta gacacaattg gctgagcagg     2100

atatgtgata ctgtgtggtt ggtgtggagt tttgaagaag gggctgtgtt tgggccacgt     2160

aggctctact cagagacctg aaaccacttc agaatggtgc atatgtcgaa agagctggct     2220

gggggccttg cccaaaccaa ctgaggtctt aaagtccagg gaaaaaaagt ctgggttcca     2280

actagaattc tagaaatatt tctagaacac acagagaggg aataagtccc tctatcaccc     2340

ttattaccaa gccttgtggt tccctgtgat tttagataat gtctgatatt tttctggcta     2400

tttgcctagt aggatttaaa aaatattttc aaagtgaagc tgagagagaa tcttggaaac     2460

acacatacct gttgatcatg ggccctgcag aattggccct tgggggcttt atttggttac     2520

atgtgcctgg gtggtcttta ccagcttaga ctctatcatg ggcccccatg aagctccatt     2580

ctcaatactg aataattatt acttcccttg ttgagtttct ttttctgtca tgccctgggg     2640

gcttctgctc ttctcaccag aaagaacatt tgaatctgga ttcttgtaca cctgggttag     2700

accctgttca gaggtgtggc caatttatcc cgatctcctg gaaggctgtt gtgatttcca     2760

tctaagaaat gagggtcttg agaatcaacc agtcccaaga ttagcctgtt atcctgttat     2820

ctactgagac cccaaatttc tcaccaatgt tttgggagat cctggaaaag atcccttcag     2880

tttggggtgt caccaagact tctacacaac ccaggactac cattgacctc agagctgtac     2940

cccacatctt gaagtaaatt gatcccacca ggtcccacgt ttgttatctc tgcctaaatg     3000

ttagcttctc catcctcacc acatgatgac ctgctgtgtc cctctgagca ctacccagtg     3060

gctgaaaact ctgcaaatgg gccacacttt tgcaaaatac ttgtatctga cacttaggtc     3120

ttgtttgaag aatttccttt ctggaaggtt ttacaagaag actgatagtc tttcaagccc     3180

ccacatcaca ggcttaggga cggcactaac tttctcccag ggatctaact ggctagttca     3240

aattatcact cttttacctt catataaaat gtctccccca aacctttttc ccttctttgt     3300

cattgttatc tgctaagccc ctggtcattt ccccatattc gtagtctttt tttccatcct     3360

atctttctaa tatttgttgt ctttaacaaa ctgtgttctg tgtctgtgct cctccttccc     3420

tctcagacca ctggaatgca agtccttctt ccctttggaa tgtactctgg atcccttccc     3480

ctgctttgac ccccagactt tgctccatct attattgctt ctccatcctg gatccttgac     3540

atttgtcacc ccactggcct tctcaggtgc aatcagtaaa aatgctgaga actcttggat     3600

cttaatcttc atgactgagt tttttttagt tgtatagtta tcatctgcct ttcttcactt     3660

tgcatttctt cttgaatcca ttgcagattg acttccactc ccactccttc actaaaaggg     3720

ctcttaccaa gatcaaatct aatgggtaca ttttagttcc tatgtgattt ggcctttcga     3780

tgtcaatcat cactcccagc cattgatttt ggtgacccac ttccctgtga tgatcttctg     3840

atctagtttc tcaggttcct tcgctggtcc tttttctttc cctgcccctg acatattgac     3900

atttcctgga gttggttttg tccttgattc attctcatgt cattctgcac acagtctctg     3960

catgaactca ggcagaccct tcatttaatg accaccttag ggctgatgat tctcaaatct     4020

gtattccccg atcttgcatt tgagctccag ccccactcat cctctcggat gttctgcagg     4080

cccagcaaac tcatcatgtc caaagtgaaa ctttttctct ttcctgtctc ctctcctctg     4140

atctgttctt tcttggaaca ccacccaaga acgtcacctc ctccatcaga ttgtgagctc     4200

ctggagggca ggagctgtgt ccttctattc atcttcctat ccccagaacc ttgcacagat     4260

cctggaatgt ggtaggtgct cagtaaatgt gtgttgaata aatgaatgaa tgaatgaaca     4320

aatgaatgaa tttgcttact tcaaggcaaa agaaccatga aactgtattt tgagtttcta     4380

tgttatagca gtcagcaaat cctattaaat actttgtgtt tccaagcaaa taa            4433


<210> 2860
<211> 2079
<212> DNA
<213> Homo sapiens

<400> 2860
agtatcgcaa aataggccaa gtcgctgccc tctactcaac tcgcagggcg ggaggatgga       60

gacagaggga tgcggcggga gggcgggaca gcccagtcgc cgccaaggag gcgaagcggg      120

gtcggggtag ctcacccgcc ccccgcagtc cccgcccccc gcagtccccg ccccgcgcgg      180

cgccgcgcac gcctgaagtc attgcccgag gccccgcccc ctcgcggccc cagccccggc      240

tctggctctg ccggcggagg gggcggagag aacccgcagc tgcaacttcg cctggagcct      300

ttgagcctgg gctcagccgg ggatctagca gccgtcaccg ccgagtcgcc gcttccccgg      360

cgcgggcctc agcccagccg gcttggccat ggcaggcgcc ggcagtgcgg cgaatctggc      420

ccctgcgctc cccgcccgta gctgagcagc cgttaaccag ccatcccgcc tttcctcctg      480

cccgtgtcgc cgaggcccac gctccgcgca agtttccgcc gccgaagaag caggaggacg      540

gacgtgagga gtcgggcgtc cctggcccac ccggccctct cgcccgcgat gtgggggcgc      600

ttcctggctc cggaggccag cggccgggat agccccggcg gagcccgcag cttccctgcc      660

ggcccagatt attcatcagc atggctacct gctaatgaat cattgtggca ggccacaact      720

gttccatcta accatcgaaa taaccatatc aggagacaca gtatagcttc tgacagtgga      780

gacactggca ttggaacttc ctgttctgat agcgtggaag atcattcaac ttcaagtggc      840

acattatctt ttaagcctag tcaatcattg attactcttc ctactgccca tgtgatgccg      900

tctaattcca gcgcttcaat ttccaaactt agggaatcat tgacaccaga tggctcaaaa      960

tggagtacaa gcctcatgca aacattggga aaccacagta ggggggagca ggactcttcc     1020

ctagacatga aggacttccg gccacttcgg aaatggtcat ctttatccaa actcactgcc     1080

ccggataact gtggccaggg tggcactgta tgcagagaag agtcaaggaa tggtttggag     1140

aagataggga aggctaaggc tttaacatca caactgagga caattgggcc tagctgttta     1200

catgatagta tggagatgct taggttagag gacaaggaaa taaataaaaa acggtcatca     1260

actctggact gcaagtataa atttgagagc tgtagcaagg aggactttag agcctcttcc     1320

tctactctta ggagacagcc tgtagacatg acatatagtg ccttacctga aagcaagccc     1380

attatgacaa gctcagaggc ttttgaacct ccaaaatatt taatgcttgg tcaacaggca     1440

gtaggtggag ttcccattca gccttccgta aggactcaga tgtggcttac agagcagctg     1500

cggacaaatc ctttggaagg tagaaataca gaggattctt acagtttagc tccttggcaa     1560

cagcagcaaa ttgaagactt tcgacaagga agtgaaacac caatgcaggt tttgactgga     1620

tcatctcgtc aaagttattc acctggctat caggatttca gtaagtggga atcaatgttg     1680

aaaataaaag aaggacttct aaggcagaaa gaaattgtaa tcgatcggca gaagcaacaa     1740

attacccacc tgcatgagag gataagggat aatgaattac gggctcaaca tgccatgtta     1800

ggacattatg taaattgtga ggattcttat gtggctagtt tgcagccaca atatgagaac     1860

acttcactcc agacaccatt ttcagaggaa tcagtttccc attcccaaca aggggaattt     1920

gagcaaaagc ttgcatctac tgagaaagaa gttttacagc ttaatgagtt tctcaaacaa     1980

agactaagcc tatttagtga agagaagaag aaactagagg aaaaagtagg tttttctaat     2040

aaagttgaat taggtcaaca acatttcctc agcatataa                            2079


<210> 2861
<211> 1718
<212> DNA
<213> Homo sapiens

<400> 2861
ccaggaccag ggagcaatca cagctgcccc gaccttggct tcctctgctg ggtgggattg       60

ggggctgggc ccccaaatgg gcccctggct tcccccttcc tctgggcagg ggacagagag      120

acacaggctc ggggagcagg actgacttcc tcttgtcccg gaatgagcat gcctgccctt      180

tgcaagcagg tttgggtctc acgcagagga aaccaaaagc aataagaggg agggaaggca      240

gagcaaccaa tcaagggcag ggtgagactc aaaacgagcg ggctccctgg ggagccagac      300

agaggctggg ggtgatggcg gagctacagc agctgcagga gtttgagatc cccactggcc      360

gggaggctct gaggggcaac cacagtgccc tgctgcgggt cgctgactac tgcgaggaca      420

actatgtgca ggccacagac aagcggaagg cgctggagga gaccatggcc ttcactaccc      480

aggcactggc cagcgtggcc taccaggtgg gcaacctggc cgggcacact ctgcgcatgt      540

tggacctgca gggggccgcc ctgcggcagg tggaagcccg tatggtgaac atgcatatgg      600

agaaggtggc ccgaagggag atcggcacct tagccactgt ccagcggctg ccccccggcc      660

agaaggtcat cgccccagag aacctacccc ctctcacgcc ctactgcagg agacccctca      720

actttggctg cctggacgac attggccatg ggatcaagga cctcagcacg cagctgtcaa      780

gaacaggcac cctgtctcga aagagcatca aggcccctgc cacacccgcc tccgccacct      840

tggggagacc accccggatt cccgagccag tgcacctgcc ggtggtgccc gacggcagac      900

tctccgccgc ctcctctgcg ttttccctgg cctcggccgg cagcgccgaa ggtgtcggtg      960

gggcccccac gcccaagggg caggcagcac ctccagcccc acctctcccc agctccttgg     1020

acccacctcc tccaccagca gccgtcgagg tgttccagcg gcctcccacg ctggaggagt     1080

tgtccccacc cccaccggac gaagagctgc ccctgccact ggacctgcct cctcctccac     1140

ccctggatgg agatgaattg gggctgcctc cacccccacc aggatttggg cctgatgagc     1200

ccagctgggt gcctgcctca tacttggaga aagtggtgac actgtaccca tacaccagcc     1260

agaaggacaa tgagctctcc ttctctgagg gcactgtcat ctgtgtcact cgccgctact     1320

ccgatggctg gtgcgagggc gtcagctcag aggggactgg attcttccct gggaactatg     1380

tggagcccag ctgctgacag cccagggctc tctgggcagc tgatgtctgc actgagtggg     1440

tttcatgagc cccaagccaa aaccagctcc agtcacagct ggactgggtc tgcccacctc     1500

ttgggctgtg agctgtgttc tgtccttcct cccatcggag ggagaagggg tcctggggag     1560

agagaattta tccagaggcc tgctgcagat ggggaagagc tggaaaccaa gaagtttgtc     1620

aacagaggac ccctactcca tgcaggacag ggtctcctgc tgcaagtccc aactttgaat     1680

aaaacagatg atgtcctgtg actgccccac agagataa                             1718


<210> 2862
<211> 553
<212> DNA
<213> Homo sapiens

<400> 2862
agtcggcggc cggactggga agatggacgc agtaaccagt agattctcca agctgctttt       60

ccgtgacgag aaagagaaac agtgaatttg tatcatcggg tcttagtttc ttggggtcct      120

aagagagaga gaaagagaag gactactctg acctacgaca ctctccggtt tgctgagttt      180

gaagattttc ctgagacctc agagcccgtt tggatactgg gtagaaaata cagcattttc      240

acagaaaagg acgagatctt gtctgatgtg gcatctagac tttggtttac atacaggaaa      300

aactttccag ccattggggg gacaggcccc acctcggaca caggctgggg ctgcatgctg      360

cggtgtggac agatgatctt tgcccaagcc ctggtgtgcc ggcacctagg ccgagattgg      420

aggtggacac aaaggaagag gcagccagac agctacttca gcgtcctcaa cgcattcatc      480

gacaggaagg acagttacta ctccattcac cagatagcgc aaatgggagt tggcgaaggc      540

aagtccatag gcc                                                         553


<210> 2863
<211> 2820
<212> DNA
<213> Homo sapiens

<400> 2863
ccgcggagtt acgggaaagt tggtccgagt tcccagagtt tccctctgtg gtgccctagg       60

ctcggccggc cggtgccccg gctcctttcc tcctttcggc cttcgccgtc caccaggtcc      120

ctctctctgt ccccggccgc catggagcag ccgccggcgc ctaagagtaa actaaaaaag      180

ctgagtgaag acagtttgac taagcagcct gaagaagttt ttgatgtatt agagaagctt      240

ggagaagggt cttatggaag tgtatttaaa gcaatacaca aggaatccgg tcaagttgtc      300

gcaattaaac aagtacctgt tgaatcagat cttcaggaaa taatcaaaga aatttccata      360

atgcagcaat gtgacagccc atatgttgta aagtactatg gcagttattt taagaataca      420

gacctctgga ttgttatgga gtactgtggc gctggctctg tctcagacat aattagatta      480

cgaaacaaga cattaataga agatgaaatt gcaaccattc ttaaatctac attgaaagga      540

ctagaatatt tgcactttat gagaaaaata cacagagata taaaagctgg aaatattctc      600

ctcaatacag aaggacatgc aaaattggca gattttggag tggctggtca gttaacagat      660

acaatggcaa aacgcaatac tgtaatagga actccatttt ggatggctcc tgaggtgatt      720

caagaaatag gctataactg tgtggccgac atctggtccc ttggcattac ttctatagaa      780

atggctgaag gaaaacctcc ttatgctgat atacatccaa tgagggctat ttttatgatt      840

cccacaaatc caccaccaac attcagaaag ccagaacttt ggtccgatga tttcaccgat      900

tttgttaaaa agtgtttggt gaagaatcct gagcagagag ctactgcaac acaactttta      960

cagcatcctt ttatcaagaa tgccaaacct gtatcaatat taagagacct gatcacagaa     1020

gctatggaga tcaaagctaa aagacatgag gaacagcaac gagaattgga agaggaagaa     1080

gaaaattcgg atgaagatga gctggattcc cacaccatgg tgaagactag tgtggagagt     1140

gtgggcacca tgcgggccac aagcacgatg agtgaagggg cccagaccat gattgaacat     1200

aatagcacga tgttggaatc cgacttgggg accatggtga taaacagtga ggatgaggaa     1260

gaagaagatg gaactatgaa aagaaatgca acctcaccac aagtacaaag accatctttc     1320

atggactact ttgataagca agacttcaag aataagagtc acgaaaactg taatcagaac     1380

atgcatgaac ccttccctat gtccaaaaac gtttttcctg ataactggaa agttcctcaa     1440

gatggagact ttgacttttt gaaaaatcta agtttagaag aactacagat gcggttaaaa     1500

gcactggacc ccatgatgga acgggagata gaagaacttc gtcagagata cactgcgaaa     1560

agacagccca ttctggatgc gatggatgca aagaaaagaa ggcagcaaaa cttttgagtc     1620

taatttcctc tctgttttta actattctgg agaccaagaa accactagga attgaaggaa     1680

tatttggata tttttaatcc taagattttg ccctacaatt aggcagaggt caaaaagtga     1740

caatggtaca tgcccaggta aattcccaaa aggcagaatt gacagttgta tctgctgtgc     1800

attcactcta agatgaggag aacaaaagaa gtgtattctc ttgttctgtc agctgcatac     1860

cagtaataaa actgttatga aatggatttt caaggtctct aaaccttgaa aatccaaagc     1920

tattgttgca ttgtacagca ctgaagggct ttatgttaca atattcttta ttcctatcta     1980

gtatactagg ctatttattg tatcccctta ggtaaactta tttatttatg ctattttgct     2040

ttgtttcatt ttttaaggac aagatcagga tagctttggt gaaggtaggg tcatattaat     2100

atgatgataa tgtgcaacca atttatactt tctgcaggga gctatggggt acattccttg     2160

atttccagga tagtttttca aataggaaag caataatggc agtagttctc aaatgggcta     2220

ggcctttttt atattgaagc aataattcca tttttaccct ttgaaatttt gtttttttga     2280

tttttgatgt ttggtacaaa tagaactata tatatttagg taaaatagat ctatcgtgtt     2340

taaaaccaaa gaaatcaatg gaacccttgc acaaaaaagt gtgataaata tttttaaata     2400

aaaacttaat acaaatgtaa tttgttaata ttgtttcatg ttttatgtgt agatctaata     2460

gctgaactga ttcaaactgt aataagctca tcaatttcat ttctatgaaa atgtgctctg     2520

ttgtcacagg atgtttctgt tgattttatt catttcctgg gaattggtaa acatcatgtt     2580

cctgatgata acccagtagc aaaaacattt gtactgagtg gtacaagcct tggggactga     2640

aaaaaaaaag attaaaacca ttaaaaagaa actcattttt acgctgaatg aacatttata     2700

tgattgcatt gggaccagtc atttcctaag ctacatatgg ccatcttgac agtgtttttt     2760

cttttgtgtg tttaattatt atgtgtaaat cataaagaca aataaatttc actgtgccac     2820


<210> 2864
<211> 439
<212> DNA
<213> Homo sapiens

<400> 2864
gctgggcctg gaacagtcgg agcagccgct agcagaagga tgacccaaga cgggaagcgg       60

gctgctgagc ctcgccgatt cccgtgcttg taactgcccc agccggacac cccccctccc      120

ttgacctacc cggtctgtgt ctcgttccgg ctcggcctgc gccccccctc gcttcccagc      180

cggtttcccc taaggatggg cctgacccgt atcccaagct cttagcgctc aggtcttttc      240

cttccgccga cccgaagtca tcgctgggag tactggttgc cctttcctca ggctggctac      300

agcaaacatc attcaagatg tccagcaaag ggagcagcac agatggcaga acagacttag      360

ctaatggaag cctgtctagc agtccagagg agatgtctgg agctgaagag gggagggaga      420

catcctcagg cattgaagt                                                   439


<210> 2865
<211> 1765
<212> DNA
<213> Homo sapiens

<400> 2865
aaacaccaca gatgcccatc aaaggggcgc acgggtctgg aggcgcagct caggtttttg       60

cgttggtcac cctgccctcc gcacgtggag agggcaggca taaagcacct tgaaaggaag      120

gtgctgtcaa tgctatccga cgacctgtcg ccgggcaccg cagcatcctc gctcgctccg      180

atgggacgag ggacgccggc cccagggtaa caggaggcgc ctcgccggcc gcgcgctgga      240

tgctgtgatc caggtccgga gccgggttcc gccgcggccg cagcgacccg accccacccg      300

acaggccaga ggagctcatt ttgcagctct caagctttta tagcatgctg taaacaattg      360

tcaaagttgt ttatcaagaa acagatagag ttgcaacttg tttctagtaa tagaaacttt      420

tacactgcat tcaatgccta acgttgcaga aacagaaagg tcaaatgatt ctggaaatgg      480

tgagcacaaa tctgagagaa agtcacctga agagaatcta caaggtgctg taaaatcttt      540

ctgcacaagt gcctcaggag cacccttggg tcccaaagga gatggtcatt atccatggag      600

ttgtccagtg actcatacac gggaaaaaat ttatgccatc tgttcggact atgcctttct      660

caaccaggcg acctcaatct ataaaactcc aaatccatcc cgctctcctt gcctccctga      720

tagtacctct ttatctgctg gaaataattc atcaagatac attggtatcc cgactagtac      780

atcggaaatt atctacaatg aagaaaatag cttggaaaac ttatccaaca gcctgggcaa      840

gctacctctc gcatgggaaa ttgataaatc tgaatttgat ggggtgacca caaattcgaa      900

acacaaatca ggcaatgcaa agaaacaagt ttccaagaga aaaacttcag ataaaaaggg      960

aagatatcag aaggaatgtc ctcagcattc tcctcttgaa gatattaaac agcggaaagt     1020

attagacctc agacgatggt actgcataag ccgaccacag tataagactt cttgtggcat     1080

ctcttcatta atttcttgtt ggaatttctt atacagcaca atgggagctg gaaaccttcc     1140

acctattacc caagaagaag ctttacatat tctgggcttt caacctccat ttgaagatat     1200

taggtttggt cctttcacgg ggaatacaac acttatgagg tggtttagac aaattaatga     1260

ccacttccat gtaaaaggat gctcttatgt tctatataag cctcatggga agaataaaac     1320

agcaggagaa actgcagggg acctctctca ccacaggaag ttgaatattg gatcttaatt     1380

ggagaatcaa gtagaaaaca tcctgccatt cactgtaaaa aatgggcaga tattgttact     1440

gatctaaaca ctcaaaatcc agaatacctg gatatccggc acttagagag gggactgcag     1500

tatagaaaaa caaagaaggt tgggggaaat ttgcattgca tcatagcatt ccagagactt     1560

aactggcaaa gatttggcct ttggaacttt ccatttggaa ccattagaca agaatcacaa     1620

cctccaacac atgcccaggg aattgccaaa tctgagagtg aagacaatat ttccaagaag     1680

cagcatgggc gtctgggccg gtctttcagt gctagtttcc atcaggactc ggcatggaaa     1740

aagatgtcta gtatccatga gagaa                                           1765


<210> 2866
<211> 1798
<212> DNA
<213> Homo sapiens

<400> 2866
atcaccgcag gcgggcctcg cgggtccggg agcgcggcgg agacgatgcc tgagatcaga       60

gtcacgccct tgggggccgg ccaggacgtg ggccgaagct gcatcctggt ctccattgcg      120

ggcaagaatg tcatgctgga ctgtggaatg cacatgggct tcaatgacga cgtagatgat      180

gagctggaga tcaaggccta ctatgcaggc cacgtgctgg gggcagccat gttccagatt      240

aaagtgggct cagagtctgt ggtctacacg ggtgattata acatgacccc agaccgacac      300

ttaggagctg cctggattga caagtgccgc cccaacctgc tcatcacaga gtccacgtac      360

gccacgacca tccgtgactc caagcgctgc cgggagcgag acttcctgaa gaaagtccac      420

gagaccgtgg agcgtggtgg gaaggtgctg atacctgtgt tcgcgctggg ccgcgcccag      480

gagctctgca tcctcctgga gaccttctgg gagcgcatga acctgaaggt gcccatctac      540

ttctccacgg ggctgaccga gaaggccaac cactactaca agctgttcat cccctggacc      600

aaccagaaga tccgcaagac tttcgtgcag aggaacatgt ttgagttcaa gcacatcaag      660

gccttcgacc gggcttttgc tgacaaccca ggaccgatgg ttgtgtttgc cacgccagga      720

atgctgcacg ctgggcagtc cctgcagatc ttccggaaat gggccggaaa cgaaaagaac      780

atggtcatca tgcccggcta ctgcgtgcag ggcaccgtcg gccacaagat cctcagcggg      840

cagcggaagc tcgagatgga ggggcggcag gtgctggagg tcaagatgca ggtggagtac      900

atgtcattca gcgcacacgc ggacgccaag ggcatcatgc agctggtggg ccaggcagag      960

ccggagagcg tgctgctggt gcatggcgag gccaagaaga tggagttcct gaagcagaag     1020

atcgagcagg agctccgggt caactgctac atgccggcca atggcgagac ggtgacgctg     1080

cccacaagcc ccagcatccc cgtaggcatc tcgctggggc tgctgaagcg ggagatggcg     1140

caggggctgc tccctgaggc caagaagcct cggctcctgc acggcaccct gatcatgaag     1200

gacagcaact tccggctggt gtcctcagag caagccctca aagagctggg tctggctgag     1260

caccagctgc gcttcacctg ccgcgtgcac ctgcatgaca cacgcaagga gcaggagacg     1320

gcattgcgcg tctacagcca cctcaagagc gtcctgaagg accactgtgt gcagcacctc     1380

ccagacggct ctgtgactgt ggagtccgtc ctcctccagg ccgccgcccc ttctgaggac     1440

ccaggcacca aggtgctgct ggtctcctgg acctaccagg acgaggagct ggggagcttc     1500

ctcacatctc tgctgaagaa gggcctcccc caggccccca gctgaggccg gcaactcacc     1560

cagccgccac ctctgccctc tcccagctgg acagaccctg ggcctgcact tcaggactgt     1620

gggtgccctg ggtgaacaga ccctgcaggt cccatccctg gggacagagg ccttgtgtca     1680

cctgcctgcc caggcagctg tttgcagctg aagaaacaaa ctggtctcca ggctgtcttg     1740

cctttattcc tggttagggc aggtggtcct agacagcagt ttccagtaaa agctgaac       1798


<210> 2867
<211> 394
<212> DNA
<213> Homo sapiens

<400> 2867
ggaaccatca gttgttcaac aggcacgtta cagaggagga atctgggccc agagaggcag       60

actggattac tgctgctggg aatgaaagag aatcaagaat taaagacaat ccaggccaat      120

ctgtcgaggc agagggtaga acaccagtgt ctttcatctg aggaactgaa gcaacgtttc      180

ccaaatattc ggttgcccag gggagaagtg gggctcttgg acaattccgg aggagttatc      240

tatgcatata aggccctcag agccctgcag gatgcaattc gacagctagg aggcatagtg      300

cgtgacggag agaaggtggt ggagataaac ccagggctac tggtcacggt gaaaaccacc      360

tccaggagct accaagctaa gagcttggtc atca                                  394


<210> 2868
<211> 2749
<212> DNA
<213> Homo sapiens

<400> 2868
gcggggcttg gggctggatc tatgagccgg gagcggggat ccaggagcga ggagccggga       60

gcggggaaca gggagtcggg gagccgggaa ccagggctgg cagcggccgc catgagcacg      120

gtggaccttg ctcgcgtggg cgcgtgcatc ctgaagcatg cggtgaccgg ggaggccgtg      180

gagctgcgga gcctgtggcg ggagcacgcg tgcgtggtgg ccgggctgcg gcgcttcggg      240

tgcgtggtgt gccgctggat cgcccaggac ctcagcagcc ttgctgggct cctggaccaa      300

cacggcgtgc gcctggtggg cgtagggccc gaggccctgg gtctgcagga gttcctggac      360

ggcgactact tcgcgggaga gctctacctg gatgagagca agcagcttta caaggagcta      420

ggcttcaagc ggtacaacag cctgagcatc ctcccagcag ctctggggaa gcccgtgcgt      480

gatgtggctg ccaaggccaa ggctgttggc atccagggga acttgtctgg ggacctgctg      540

cagagcggag ggctgctggt ggtcagcaaa ggtggtgata aagtgctcct gcatttcgtc      600

cagaagtccc caggcgacta cgtccccaag gagcacatcc tgcaggtcct gggcatctct      660

gcggaggtct gtgccagcga cccgcctcag tgtgacagag aggtgtgagg gaggcgaagg      720

ccctggcctc cgaggatctg ggtggcgtct gctgccctag gtgtgctgga agtccacttg      780

gaagaactgt tccggaggcg ctgggtcggg atgccgaacc tctcctgatc cgccggcagc      840

aacgagccat taaaactgca gttcctgacc acgcactgct tcgcaggctc cgagccctgc      900

atcctccaca gcccccgcct tgctcactgt tgggccctca gggcgggcag ggtggctgtg      960

agtcccaggt gtcatcttcc tgctctgcga ctttctctgg agaccttggg cctttggcct     1020

gtggggcact ggggatggta acctcactgc cccgtcactc ccttcaaagg cgacagaccc     1080

aagcccacgt caggagagga gcgtggggtc agctccagca gggtcggggt cagtgcctgt     1140

gtctggtggg ggccactcag gagagttggg ttttcagggc agagatgggc ttgattccac     1200

ctggtggggt gggtggaccc tggagactct caggtgatgg gccagcctgc cccaaggctc     1260

tttactgatg tcagaatcat tgtttgcacc tgctgggtat ggcctttggg gcggccggcc     1320

cgggagggtc ttagtctaat taggtgtgtc cagcttcttg gccacctttc cctggggacc     1380

ctaacaggcc cagagcagag ccccttacct cccaggtcag actacctgct caggccctcc     1440

cctcccatgc aggccgatga caactgcagc cctctctgca ctccctagtc cagacctggg     1500

gaccactgtg ggttcctgtg ggtctcccgg ctcccttcct gcccccaatg ccacccttgc     1560

agtggccatt taaaaatgca tagcaggtga cccactgcgt ccctttgcgt tcagcccctc     1620

ctctggcttt cagttacacc aagctaaaat ttcaggttcc cagctgcagc tctctgggtc     1680

ccccggtgcc ccagtggggc tccccgcatc tgaatgtgtg gtccctgggg gtgggcactt     1740

gggggcatcc tggtcactgc tggccctagc attggaccct aggagacctg actggaactg     1800

gctccctccc catcagctcc cagctgtcac tctctcccac ccccgggcag ctgttttgcc     1860

caagaccact gctacctgtt tacccaccct ggtccctccc agacaagcaa ggcctctgat     1920

ttctttgaag catttactta gctcaagtct gaagctgtag atactggaag acaatgcacc     1980

ttggagggtg ggcaggacac agttgattgt ctctacagag ctgtgacggg ggcactgagc     2040

cccgcgggtg tctgtggagg gggctccggt ccaggtactg cactggacac tgctcatccc     2100

tgggtgtcag gcaggtggct gcaccctagg ccaggcgcag aggcctggca ggcaggcttg     2160

gcatggttgg ccggggcggg acgtacactg ggtcgccgct agctgcacct tcgcacagat     2220

gcctccgagc agcgggtggg cgtgggccgc acagcgcggc agggccttgg ctaccacacg     2280

cggcatcgct ccttggggtg catgggggtg ccccgggcac agtggaacgt gtctgcgaag     2340

gcggccaggt tctgcagcga ccccagtacc ctgtgggtgg gtgggtgtga cagcaggagc     2400

attgccatct tggacaaaca tggccatttt aagttctccg tgattaaaaa ccagcccaaa     2460

acatcagcct aatggctcat gtcagtatga gcagaaacat ttcaaccatg agataaaccc     2520

ccatctgacc agaaacatgc caatcctgag aataacctcc cctccagcca gagatattcc     2580

aactctgcaa taaaactctc cttcacacag aaacattcgc agcctgcggt aggctccccc     2640

ttcctaaacc cttaaatgcc cttagtctgt aagagaatgt ccctgaccga aatcggccag     2700

aagcccctct caggtttatt cccaaaataa acctgtctct gttgagcca                 2749


<210> 2869
<211> 715
<212> DNA
<213> Homo sapiens

<400> 2869
gctgcgcgcc caggggtccc gcgggttttc gggcgcaggg tggcgcccgc ggcaggcggc       60

ggccatgaac ttctccgagg tattcaagct ctccagctta ctctgcaagt tctccccgga      120

cggcaagtac ctggcttcct gtgtccagta ccggttagtg gtccgggatg tgaacaccct      180

tcagatcctt cagctgtaca cgtgcctaga ccagatccag cacatcgagt ggtcggcaga      240

ctcgctcttc atcctgtgcg ccatgtacaa gcgagggctg gtgcaggtct ggtctttaga      300

gcagcccgaa tggcactgca aaatagacga gggctcagcc gggctggtgg cctcgtgctg      360

gagcccggac gggcgccaca ttctcaacac cacggaattc catctgcgga taaccgtctg      420

gtccttgtgc acaaaatccg tgtcttacat caaatacccg aaagcttgtc tgcagggaat      480

caccttcacc agggacggcc gctacatggc gctggcagaa cggcgcgact gcaaagatta      540

cgtgagcatc ttcgtctgca gtgattggca gctcctgcgg tacaagattc tgctgtactc      600

attggatggc cggttgttgt ccacgtacag cgcttacgag tggtccctgg gcatcaagtc      660

tgtggcctgg agccccagca gtcagttcct ggcagttggg agctatgatg gaaag           715


<210> 2870
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 2870
ccggagcggg gatcacctca acttgactgt ggtcccccag ccctccaaga aatgcccata       60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa      120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt      180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt      240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca      300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc      360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc      420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc      480

tcctccgtcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc      540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg      600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc      660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg      720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct      780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc      840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc      900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac      960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga     1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg     1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg     1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct     1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc     1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta     1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct     1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat     1440

ataattcccc tctgga                                                     1456


<210> 2871
<211> 1244
<212> DNA
<213> Homo sapiens

<400> 2871
ggcgagcccc gcggggaggc cgaggcgcgg gtgcgggcgc cggcgtagcc gcggcggtag       60

cgtcacgcag cgaggccgtg cgtgcgcggg cgtcagggcg gcgctgagtt gaggacgctg      120

gcggctccgc gacgagcttt gttttttcgg ttgggcatgc tgcttaccgc aggatgatgg      180

aagcgacggc ccgtacaaag acagaagcgt tggtttcact gagtcagtgc tgattctctc      240

aaatagagct tgaaggataa atcttcattt ttgtttcaac aaaacttcga aacaaaatgg      300

aagaaaataa tctacagtgc agtagtgtgg ttgacggtaa ttttgaagaa gttcccaggg      360

agacggcaat tcagtttaaa cctccactat acagacagcg gtaccagttc gttaaaaatt      420

tagtggatca acatgagcct aagaaggttg cagacctggg atgtggtgat acttcactct      480

taaggctgct aaaagtcaat ccatgcattg aattgcttgt tggagtagat attaatgagg      540

ataaattacg atggagaggg gattcgttag ctcctttcct gggggatttt ctgaaacctc      600

gggatctgaa tttgaccatc acattgtatc atggctccgt tgtggagaga gactctcgtt      660

tgcttggatt tgacttgata acgtgtattg aattaataga acatttggat tcaggtgatc      720

tggccagatt tcctgaagtg gtatttgggt acctgtctcc atccatgatt gtcatcagca      780

caccaaactc tgaattcaat cccctgtttc catcagtgac cttaagagat tcagatcata      840

aatttgagtg gaccagaatg gagtttcaga cctgggcttt atatgtggca aatcgctatg      900

attactctgt ggagtttact ggtgtcgggg aaccaccagc tggagctgag aatgttggat      960

actgtaccca gataggaatc ttccggaaaa atggaggaaa ggcaacagaa tcatgtcttt     1020

cagagcagca tgatcagcat gtttataaag ctgtttttac cacctcatac ccaagcttac     1080

agcaggaaag gttctttaaa cttgtgttgg ttaatgaggt gtcccaacaa gtggaaagct     1140

taagagtgag ccacctgcca aggcggaaag aacaggctgg ggaacggggt gataagccca     1200

aagacattgg tggctcaaag gcccctgtcc catgctttgg acca                      1244


<210> 2872
<211> 1748
<212> DNA
<213> Homo sapiens

<400> 2872
gctgggcccc aggccagcct ctgcctggga agttctctct gggaacatct ggtgggtact       60

acaggcccta ttccaggccc tatggcctgt ggaacctcac cacggggggg agggctgggc      120

cagacggaga catcacctgt ggtgtcagcc ccatggatga gacagagtgg atacacagac      180

atcccaaggc tgaggaccta agggttgggc tcatcagctg ggcaggaacc tacctcacct      240

ttgaggcatg caagaataca gtcactgcaa ctgcgaagag tttgggcagg agacagggcc      300

tgcctataag agcttttgct tctgtcttgc catgctggaa ggcaaccttt ggggatggag      360

gtattggcta agtgtgctct ctgcggacaa cagtgaggaa gaaaaaaacc tgggagatct      420

tggtgagcaa tgagcatgag acacaggccg tggtgcgact aaagagcgtg cagggcctct      480

acctgctgtg tgagtgtgat ggcaccgtgt gttatggccg cccaaggacc agccaccatg      540

ggtgctttct actgcgtttc caccggaaca gcaagtggac cctccagtgc ctaatctctg      600

gtcgttattt ggagtccaat ggcaaggacg tgttttgcac ttcccacgtc ctctcagctt      660

accacatgtg gaccccccga ccagccctcc atgtccacgt gatcctctac agccccatcc      720

accgctgcta tgcccgggct gaccccacta tgggccgcat ctgggtggac gcagcagttc      780

cctgcctgga ggagtgtggc ttcctgttgc atttccgaga tggatgctac cacctggaga      840

cctctacaca ccacttcttg tcccatgtag accggctgtt ctcccaaccc tcatcacaga      900

cagcttttca catgcaagtg cggcctggag ggcttgtggc actgtgtgat ggagaaggag      960

gcatgttata tccacagggc acgcatctgc tcttgggcat gggctgcaac cccatgaggg     1020

gtgaggagtg gttcatccta cagcactgcc caacctgggt cagcctcagg tcaaagactg     1080

ggcggttcat ctcagtcatc tacgatggtg aggtgcgtgc tgcttctgag cgcttaaacc     1140

gaatgtcctt gttccagttt gaatgtgaca gtgagagccc cactgtgcag cttcgttcag     1200

ccaatggcta ctacctatcc cagaggcgcc acagggcagt aatggctgat gggcaccccc     1260

tggagtctga cacgttcttc cgaatgcact ggaactgtgg caggatcatc ctgcagtcct     1320

gcagggggcg cttcctgggc attgcaccca acagcctgct gatggccaat gtcatccttc     1380

caggcccaaa tgaggaattt gggattttat ttgccaatcg ctccttcctt gtattgcgag     1440

gtcgttatgg ctatgtgggc tcctcatcgg gccatgacct catacagtgc aaccaggatc     1500

agcccgaccg cattcatcta ctaccctgcc gaccgggtat ctaccacttc caggggggga     1560

tccttctggt caataacatc ctttggcacc tttcgccctt ggggcaagtt tgccctcaac     1620

ttctgtatcg agcttcaggg gagcaactta ctcactgtac tggcccccaa tggcttctac     1680

atgcgagccg accaaagtgg caccctgttg gcagacagtg aagacattac cagagagtgt     1740

atctggga                                                              1748


<210> 2873
<211> 3621
<212> DNA
<213> Homo sapiens

<400> 2873
accccttccg atatccgcgg tggagccgcc cttcccaccc cgcgtcgctc ggcgttagcc       60

aaggcccggg cggcgccacc ctccgggggc actaggtctg gggccgcagt gcccagcaca      120

gagcagcgtt tatcgggacg aagatgaatg gaaagaattg gagcaaaaag aggttgatta      180

cagcggcctc agggttcagg caatgcaaat aagcagtgaa aaggaagaag acgataatga      240

aaagagacaa gatccaggtg ataactggga agaaggtgga ggtggtggtg gaggtatgga      300

aaaatcttca ggtccctgga ataaaacagc tccagtacaa gcacctcctg ctccagtaat      360

tgttacagaa accccagaac cagcgatgac tagtggtgtg tataggcctc ctggggccag      420

gttaaccaca acaaggaaaa caccacaagg accaccagaa atctacagtg atacacagtt      480

cccatccctg cagtcaactg ccaagcatgt agaaagccgg aagtacttaa aatgaatgct      540

acctggaatt aaatgactac atatggcaca tctacatctt actttaggga catgaatttt      600

ttaaaataaa taaaatggga agaaatgtaa atgacatcag atggaaatgt gttttttggg      660

gtggctttta gaataaatcc cagccttttc accactttga gagcacagct ggcttgaatt      720

taaacctcca cgtggacttg ctcctctgct ctgtcttaaa aaatgtgtaa gggaccttgg      780

gagggcagtg attcaccaca ctcgagtttc tttacctgat ctaatcagat ccactcccac      840

aaaatcgatg tgaggagaaa tcattgacta atgagtagaa tttacttgaa tgagaaaatt      900

gttacccttg tgcataaaga gagagatgta ttatctatta cttgctaaaa gtaagagtct      960

taggaggaat gtcattacac agcttttaac agttttcttc aagtttgtcc tgaaataggg     1020

tcacagttaa tactgttcag tagaagatag gaccctagag cttcaataca gcgttctgtg     1080

ttttctgttt gaattgaagc cttaaaatgg tttgataagg attttctata tgcctccact     1140

cctacccctc cccaggattc ttctaagggg tggctttttt ttaaattcaa ggacgaatat     1200

tttcaaaaac cctagtgaag aagaaatatt tactgattac atttcttttc ccttagggat     1260

aaagaaatgg agaagagctt tgaagtagta agacacaaaa atagaggtag ggatgaggtt     1320

tcaaaaaacc aggcccttaa acttcagcta gacaaccaat atgctgtgct tgaaaatcag     1380

aaaagcagcc actcacaata caattaagga atgggctttg ctaacccttc tgaggtaact     1440

agactgcagc taaccaccac caacagccat tcatcatctg atctctgctg gatctacaga     1500

caccgatgca gaccactcga tttcatgacc ggccctattg cactatggaa gttaaagtgt     1560

cacgactgct ctatgcatat tggatttagg ggaattttca ttgttacata aatgtgtgaa     1620

ctagtttcaa cagtgttctt tcatatttac tctgcaaata caaaaaacca aaacctgcag     1680

ccagtggtca tttcaaaatc tttttatgtt cagatactga gccttcataa gggttgacta     1740

cctcagattt gctgcactca ttgtggactt catgtggatc acaacttctg gataagaaga     1800

ttacaactat taagtgtcga tgtgaacctt gcaaccagct ctactggatt cttatcagaa     1860

atcctgcata aaaagtcagc catctgggtt ctgatctgct gtaaaagatg aagatttaag     1920

tgaccttaat taacctgtcc tgtgccctac ccttaaggaa tactctctgt agtaggctgt     1980

tgttatatta gacttcctgg aacacactgc tgaaaagaac tgatgtgttc agatcatctg     2040

tgtagggctg tgatttgtaa tttaaactaa ttgtattctg aggtaaccac aaaataaatt     2100

caaccaaact ggggtccacc aagtggggga aggggaaggg agagaataat cttgggggtt     2160

tttttttttt ggtaattttt ttatttggat agtgcttttt tgttttgttt ttgttctgca     2220

ttaaggcctt ttttgctttg acttgaaata agttctttga cagagcatat tgcttggtta     2280

attaagtaac ctaaagtatg cattaggatt gtgaaatgtc tcgtgagtat gccaatcctg     2340

agggtggaac caaatagcct ttgatgaaaa gggcagtgga ttctggaggc tctacttcag     2400

gtgctgctat aatgcctcat ctaatcagga ctaaattgtg taggaaactg cagtgggaag     2460

aatatgcttt ctgctcaggc taagagggtc actgatctgt ccttagaaat tcagagtaac     2520

atgagcaaaa cctcagctaa aacccattta agtggcatgg attgtgcatg atctttgata     2580

agaattcctc atgtacttgt gcctagtttt tcaaggtatt ggctgttcta tagatgcagt     2640

gattgtccca gctagctctg ttaccagcct tttggtgtgt ctttatgttc atttggagag     2700

tcagggcgaa agacaggtga tgtagcactt ctgtttttaa taattattgc ttaaaatacc     2760

tattaatagt tttgggtcat ttaaagggac ttgaggaagc tacccaggat tacagaagag     2820

tgtccaccta acaagatggt ctggcagttt cctagttttg tatctggttc aatagaaata     2880

tgtgaaagtg gtaatgtcat catttgatgc agagtccggg tttctctata ataaatccct     2940

ttgccaaatg catgagttgc agacttgcta ctggcaagag tgaagcaagt gggtgagtaa     3000

aactattttg acgtgggagc gttttcagat aggagtttag tcttgacgaa agtgtccgtg     3060

caggaattgg actccgagga gggttacagt atctcctgac gggacctgcc actcgcatct     3120

gggcaatgtt gacatttgag gtggcaggca ggatgcctgc cttctaatat atttgggtga     3180

gtaactgagc cagccaaggg aaggttgaat gattaaatca gaaatgggat tcttggtaaa     3240

ctgaagactt ttatttggga atgaaaaacc ttaaaaaaat ctcttcatcg ttgaactgtg     3300

cattttccct gcattttttc ccaacaaaat tttgttgggg gttatgttac tgaagaatga     3360

acagatgagt aagtggaggt gttatgtaaa ggcatattgt actcgaaatc tgaagacctg     3420

cagcagattt aaattacaac tcttgttata actttttaaa agattgtgaa aatatcaaaa     3480

tataaatgaa tcaagtttta atatactgta tgatgggtgg atgaggctgt ccattgtacc     3540

atttgtttga attctcaggc atggtttggc agtgcaagaa ttctgtaaca ttaacaaatt     3600

caataaaaag taaatatatg g                                               3621


<210> 2874
<211> 1435
<212> DNA
<213> Homo sapiens

<400> 2874
gaactcgagt tggaagaggc gagtccggtc tcaaaatgga gggccatgat ccaaaggaac       60

cagagcagtt gagaaaactg tttattggtg gtctgagctt tgaaactaca gatgatagtt      120

tacgagaaca ttttgagaaa tggggcacac tcacagattg tgtggtaatg agagaccccc      180

aaacaaaacg ttccaggggc tttggttttg tgacttattc ttgtgttgaa gaggtggatg      240

cagcaatgtg tgctcgacca cacaaggttg atgggcgtgt agtggaacca aagagagctg      300

tttctagaga ggattctgta aagcctggtg cccatctaac agtgaagaaa atttttgttg      360

gtggtattaa agaagataca gaagaatata atttgagaga ctactttgaa aagtatggca      420

agattgaaac catagaagtt atggaagaca ggcagagtgg aaaaaagaga ggatttgctt      480

ttgtaacttt tgatgatcat gatacagttg ataaaattgt tgttcagaaa taccacacta      540

ttaatgggca taattgtgaa gtgaaaaagg ccctttctaa acaagagatg cagtctgctg      600

gatcacagag aggtcgtgga ggtggatctg gcaattttat gggtcgcgga gggaactttg      660

gaggtggtgg aggtaatttt ggccgtggtg gtggcaacta tggcggtggt cctggttata      720

gtagtagagg gggctatggt ggtggtggac caggatatgg aaaccaaggt ggtggatatg      780

gtggaggtgg aggatatgat ggttacaatg aaggaggaaa ttttggcggt ggtaactatg      840

gtggtggtgg gaactataat gattttggaa attatagtgg acaacagcaa tcaaattatg      900

gacccatgaa agggggcagt tttggtggaa gaagctcggg cagtccctat ggtggtggtt      960

atggatctgg tggtggaagt ggtggatatg gtagcagaag gttctaaaaa cagcagaaaa     1020

gggctacagt tcttagcagg agagagagcg aggagttgtc aggaaagctg caggttactt     1080

tgagacagtc gtcccaaatg cattagagga actgtaaaaa tctgccacag aaggaacgat     1140

gatccatagt cagaaaagtt actgcagctt aaacaggaaa cccttcttgt tcaggactgt     1200

catagccaca gtttgcaaaa agtgcagcta ttgattaatg caatgtagtg tcaattagat     1260

gtacattcct gaggtctttt atctgttgta gctttgtctt tttctttttc ttttcattac     1320

atcaggtata ttgccctgta aattgtggta gtggtaccag gaataaaaaa ttaaggaatt     1380

tttaactttt caatatttgt gtagttcagt ttttctacat tttagtacag aaact          1435


<210> 2875
<211> 606
<212> DNA
<213> Homo sapiens

<400> 2875
aacatccagc tggtggcaga cggctgctgt aacctccaga agcaaattca gatcactcag       60

ctctttgggg ttcccgttgt ggtggctctg aatgtcttca agaccgacac ccgcgctgag      120

attgacttgg tgtgtgagct tgcaaagcgg gctggtgcct ttgatgcagt cccctgctat      180

cactggtccg ttggtggaaa aggatcggtg gacttggctc gggctgtgag agaggctgcg      240

agtaaaagaa gccgattcca gttcctgtat gatgttcagc cattctcttg atcccagtgg      300

gggctggatg aaggaagagc aaaacaaacc acgaagacag cctggagccg cagccagctc      360

tgctgacttc tgaacttcac gctctcactg cccagatggc caggggtgtt tcctcctctg      420

ctggtctttt ttaaggcagg atgtttgttg ttattgttgt tgtttttctg gttggttctt      480

aagaaattat tttctacatc ttgaaaatgc cagctggaac ctacaccagt tgttggtggg      540

gtgtgagaac tatcctttac atggacttgg agcatttgca actagagcct ccacattgaa      600

ataaac                                                                 606


<210> 2876
<211> 541
<212> DNA
<213> Homo sapiens

<400> 2876
atagacctga atgggctcag ccctagacac acttttaaag atcggattca accgcacatc       60

atgacagatg ttccggctac atttacccag gctgagtgta atggggataa accacctgaa      120

aacggtcaac aaacaatcac taaaatcagt gaggaattga ctgatgtgga cagccccctg      180

ccacactaca gggtagaacc cagtctggaa ggtgcactca ccaaaggaag tcaggaggaa      240

agaagaaaat tacaagggaa catgctgctc aactcatcca tggaggacaa aatgctaaaa      300

gaaaacccag aagagaaact ctttattgtt cataaggcta tcacagatct ttctctccaa      360

gaaactagtg ctgatgaaat gacattcaga gaagggcatc agtgggagaa gattcctctg      420

agtggcagta accaggaaat aagaagacag aaggagagga ttactgagca gcctctcaaa      480

gaggaagaag atgaggacag gaagaacaaa ggtcaccagg cagctgaaat tgaatggctg      540

g                                                                      541


<210> 2877
<211> 682
<212> DNA
<213> Homo sapiens

<400> 2877
ggaaacctgt tgagatcaca gagaatatac tgacggcata aaagggcaga accatagcag       60

ggtgcgcctc gcagtcacct ctgtgccctg ctggttgtct tcccagcgct gctgtagttg      120

ccttccatgg atctatagga gagcaagtcc tccaggagaa gaagtcctca ccagtgaacg      180

gagacctctc tgaactaagg ataccatggc cacgtcagcc ccactacgga gcctggaaga      240

ggaggtgacc tgctccatct gtcttgatta cctgcgggac cctgtgacca ttgactgtgg      300

ccacgtcttc tgccgcagct gcaccacaga cgtccgcccc atctcaggga gccgccccgt      360

ctgcccactc tgcaagaagc cttttaagaa ggagaacatc cgacccgtgt ggcaactgga      420

aaaaatcctg aaccacctga gtaccctaag gagggacaga gacaaaattc agggcttcca      480

ggcaaaggga gaagctgata tcctggccgc gctgaagaag ctccaggacc agaggcagta      540

cattgtggct gagtttgagc agggtcatca gttcctgagg gagcgggagg aacacctgct      600

ggaacagctg gcgaagctgg agcaggagct cacggagggc agggagaagt tcaagagccg      660

gggcgtcggg gagcttgccc gg                                               682


<210> 2878
<211> 801
<212> DNA
<213> Homo sapiens

<400> 2878
aggcgcagtg tggtgagcga gccgaagcgc gggaagcagc tcttgtggat cctcagtggc       60

ggaggctcgg tcacccggtt ttattgtgac ttgtggaagt gatggtgatg tgaggatttg      120

ggaagacttg gatgatgatg atcctaagtt cattaatgtt ggagaaaagg catattcatg      180

tgctttgaag agtggaaaac tggtcactgc agtttctaat aatactattc aagtccacac      240

atttcctgaa ggagttccag atggtatatt gactcgcttc actacaaatg caaaccatgt      300

ggtctttaat ggggatggta ctaaaattgc tgctggatct agtgattttc tagtcaaaat      360

tgtggatgtg atggatagca gccaacagaa aacatttcga ggacatgatg cccctgtttt      420

aagtctttcc tttgatccta aggacatctt tctggcatca gctagttgtg atggatctgt      480

cagagtgtgg caaatttcag atcagacatg tgctattagt tggccactgc tacaaaaatg      540

caacgatgtg ataaatgcaa aatcaatctg cagacttgct tggcagccaa aaagtgggaa      600

gttactggca attcctgtgg aaaaatctgt taagctatat agaagagaat cttggagtca      660

tcaatttgat ctttcagata atttcatctc tcagaccctc aatatagtaa cctggtctcc      720

ctgtgggcaa tatttagctg caggtagtat taatggtcta atcatagttt ggaatgtgga      780

aaccaaagac tgcatggaaa g                                                801


<210> 2879
<211> 2682
<212> DNA
<213> Homo sapiens

<400> 2879
cccgctcctc ccccgacaag gcgatgaggt aatcgcgccg ctgagaggca cgcgcagccg       60

gtgcctagcc ggttggtccc tgcgcccctg ccccgccggc caccgccccc ccacaccgtc      120

ccggccccgg cagcctggcc ccaccatgac cgagcggtgc agcctgtgga gtgccctgtc      180

ggccgccgcc tgctgcttct accgcggctc cttcgtgcag gtgcagttct ccaaggagaa      240

gtacatcctg gactcatcgc cagagaaact ccacaaggaa ttggaggagg agctcaaact      300

cagcagcacg gatctccgca gccatgcctg gtaccatggc cgcatccccc gagaggtctc      360

ggagaccttg gtacaacgca acggcgactt cctcatccgg gactcactca ccagcctggg      420

cgactatgtg ctcacgtgcc gctggcgcaa ccaggccttg cacttcaaga tcaacaaggt      480

ggtggtgaag gcaggcgaga gctacacaca catccagtac ctgtttgagc aggagagctt      540

tgaccacgtg cccgccctcg tgcgctatca tgtgggcagc cgcaaggctg tgtcagagca      600

gagtggtgcc atcatctact gcccggtgaa ccgcaccttc ccactgcgct acctcgaggc      660

cagctatggc ctgggacagg ggagtagcaa gcctgctagc cccgtcagcc cctcaggccc      720

caagggcagc cacatgaagc ggcgcagcgt caccatgacc gatgggctca ctgctgacaa      780

ggtcacccgc agcgatggct gccccaccag tacgtcgctg ccccgccctc gggactccat      840

ccgcagctgt gccctcagca tggaccagat cccagacctg cactcaccca tgtcgcccat      900

ctccgagagc cctagctccc ctgcctacag cactgtaacc cgtgtccatg ccgcccctgc      960

agccccttct gccacagcat tgcctgcctc ccctgtcgcc cgccgttcca gtgagcccca     1020

gctgtgtccc ggaagtgccc caaagaccca tggggagtca gacaagggcc cccacaccag     1080

cccctcccac acccttggca aggcctcccc gtcaccatca ctcagcagct acagtgaccc     1140

ggactctggc cactactgcc agctccagcc tcccgtgcgt ggcagccgag agtgggcagc     1200

gactgagacc tccagccagc aggccaggag ctatggggag aggctaaagg aactgtcaga     1260

aaatggggcc cctgaagggg actggggcaa gaccttcaca gtccccatcg tggaagtcac     1320

ttcttccttc aacccggcca ccttccagtc actactgatc cccagggata accggccact     1380

ggaggtgggc cttctgcgca aggtcaagga gctgctggca gaagtggatg cccggacgct     1440

ggcccggcat gtcaccaagg tggactgcct ggttgctagg atactgggcg ttaccaagga     1500

gatgcagacc ctaatgggag tccgctgggg catggaactg ctcaccctcc cccatggccg     1560

gcagctacgc ctagacctgc tggaaaggtt ccacaccatg tccatcatgc tggccgtgga     1620

catcctgggc tgcaccggct ctgcggagga gcgggcagcg ctgctgcaca agaccattca     1680

gctggcggcc gagctgcggg ggactatggg caacatgttc agcttcgcgg cggtcatggg     1740

tgccctggac atggcccaga tttctcggct ggagcagaca tgggtgaccc tgcggcagcg     1800

acacacagag ggtgccatcc tgtacgagaa gaagctcaag ccttttctca agagcctcaa     1860

cgagggcaaa gaaggcccgc cgctgagcaa caccacgttt cctcatgtgc tgcccctcat     1920

caccctgctg gagtgtgact cggccccacc agagggccct gagccctggg gcagcacgga     1980

gcacggcgtg gaggtggtgc tggctcacct ggaggccgcc cgcacagtgg cacaccacgg     2040

aggcctgtac cacaccaatg ctgaagtcaa gctgcagggg ttccaggccc ggccggagct     2100

cctggaggtg ttcagcacgg agttccagat gcgccttctc tggggcagtc agggtgccag     2160

cagcagccag gcccggcgct atgagaagtt cgacaaggtc ctcactgccc tgtcccacaa     2220

gctggaacct gctgtccgct ccagcgagct gtgaccccag ggacatttcc cctctgcagc     2280

tgcggacagc gtcaggggca gaggggcaca caactttccc cagagcaccc caaggacact     2340

gtgatcaacc cgagaatgtt ctgggttcaa ctcaagcatc tcccttgcac ctccagggtc     2400

ctgcgtggac tctgggttcc atcccacctg ctacatgctc accaggtctc cattgaggaa     2460

gaacaggaac gccggttccc ccaccagctt ttgctgctcc ccttcctgct ggggttccct     2520

gttttcgagc catgggaggc aggctgctca cgcctcctca ctctctgtct gtccctcacc     2580

aacaccaagg cctccatctc actgtaaata agtctctgtt ctgtaaatag atgtacagaa     2640

gccatgttat ttctttcata taataaactt ttatgactct tt                        2682


<210> 2880
<211> 790
<212> DNA
<213> Homo sapiens

<400> 2880
tgctttttgg gaaatgcatc agatcttttc tgttcttgaa acgccaaatc taacttggtc       60

tttttttgga tgaattaccg ccagtattat gaaggttact gtgaaggaac ttgagaccac      120

tgaacttttt gagttcttgc gactcacttt tccccttcgt ctttctctcc ctttctgtct      180

ttctgtgtct cctccaagaa tgaaatatga ctgaggactc tcagagaaac tttcgttcag      240

tatattatga gaaagtgggg tttcgtggag ttgaagaaaa gaaatcatta gaaattctcc      300

taaaagatga ccgtctggga atcttgcctc cacaccacga gtcccatgcc aaggtgatga      360

tgtatcgtaa ggagcagtac ttggatgtcc ttcatgccct gaaagtcgtt cgctttgtta      420

gtgatgccac acctcaggct gaagtctatc tccgcatgta tcagctggag tctgggaagt      480

tacctcgaag tccctctttt ccactggagc cagatgatga agtgtttctt gccatagcta      540

aagccatgga ggaaatggtg gaagatagtg tcgactgtta ctggatcacc cgacgctttg      600

tgaaccaatt aaataccaag taccgggatt ccttgcccca gttgccaaaa gcgtttgaac      660

aatacttgaa tctggaagat ggcagactgc tgactcatct gaggatgtgt tccgcggcgc      720

ccaaacttcc ttatgatctc tggttcaaga ggtgctttgc gggatgtttg cctgaatcca      780

gtttacagag                                                             790


<210> 2881
<211> 5454
<212> DNA
<213> Homo sapiens

<400> 2881
tcacagccag gtaaccctgg agtgaagcgg tttagttaga agggagcaga taaactcgtc       60

actctagtag ctttaaccct caccctgagg caccttagca atcagccatt gcctgcaagc      120

ctccaaagct tgtctttgcc taatatggag cccaaagaag ccactgggaa agaaaacatg      180

gtcaccaaga aaaagaatct ggccttcttg aggtctagac tctatatgct ggagagaagg      240

aagactgaca ctgtggttga gagcagtgtt tctggggacc actctggcac cttgaggagg      300

agccaatctg acaggactga atacaaccag aaattacaag aaaagatgac tccacagggt      360

gagtgttctg tagctgagac cttaacccca gaggaagagc atcatatgaa gaggatgatg      420

gcaaagcggg aaaagatcat taaggagctg atacagacag aaaaggatta tctcaatgat      480

ctagagctgt gtgttaggga agtggttcag cccctgagaa ataaaaagac tgataggctg      540

gatgtggata gcttgtttag caacattgag tccgtgcatc agatatcagc caagctgctg      600

tcattgttgg aagaggccac aacagacgtg gaaccggcca tgcaagtaat tggagaagta      660

ttcttgcaga ttaaagggcc actggaagat atttataaaa tctactgcta tcaccatgat      720

gaagcacata gtatactgga gtcctatgaa aaggaagaag agctgaagga acatttgagc      780

cactgtatcc agtccttaaa gaaaatatac atgcaagaag gcaaaccaaa cttattggac      840

atgggctctt tgatgatcaa accaattcaa cgtgtgatga aataccccct attactgtgc      900

gaacttcgga attccacccc tccctctcac ccagattaca gagcactgga cgatgccttt      960

gctgctgtga aggacattaa tgttaacatc aatgaactta aaagaaggaa agatttagtt     1020

ctaaaataca agaagaatga cgaggatgaa tcacttaaag acaaattgtc taaactaaat     1080

attcattcaa ttagcaagaa atcaaaaaga gtgacaaatc atctgaagat tctgaccaga     1140

ggagaatcac aggttaaaga caataccttt aacagagaag aaaagctgtt tagagcttta     1200

gaaaagactg tgaggctttg tgtgaagaac atttcactct gtcttcaaca catacaggat     1260

gccatgcccc tggctctgca gagtgtgatg gaccttcagg agatttcata caacaaagac     1320

gatgagatgg actattctga gaccctaagt aatgccttaa attcgtgtca tgactttgca     1380

tctcacttac agagactcat cctgaccccc ttgtcagccc tgctgtcctt attcccaggg     1440

cctcacaagc tcatccagaa acgctatgac aaactgctgg attgcaacag ctacctgcag     1500

cgatcaacgg gagaggagtc agacttggcc aaaaaggagt atgaggccct caacgcccag     1560

cttgtggagg agctccaggc attcaaccag gctgctcgga agattctgtt gaactgtcta     1620

tgcagcttca ttaccctcct tagggacctg atgctcgtgg cacagcaggc ttactccaca     1680

cttgtgccga tgccactgtt ggtttcaagc atttctgaga ttcagaatca agtactagaa     1740

gagatccaaa atttgaattg tgtgaaagaa aacagtgcca cctttattga gaggaaactc     1800

agttttgaaa agaagaaacc tgtgcagatt ctgccagaaa tgccacatca aactgacatt     1860

catcgctcca aacttctatc cacatatagt gcagaggaac tctatcaagc taagcgcaag     1920

tgcaatgcta cacaagaata tgacatcaat cttctggaag gagacttggt ggctgtgata     1980

gaacagaaag atccactggg gagtacaagc aggtggcttg tggacacagg aaatgtgaaa     2040

ggatatgttt attcctcctt cctaaaaccc tacaatccag caaaaatgca gaaagtggat     2100

gctgagaaca ggttctgtga cgatgatttt gagaacatca gcctcttcgt gtcttcacgg     2160

ccagctagtg acagtgtcac aggcacctca gaaagcagca ttggtgatag cagctcatct     2220

cttagtggca catgtggaaa gtttgaaaca aatggtactg atgttgacag ttttcaagaa     2280

gtagacgaac agattttcta tgcagttcat gcttttcaag cacggagtga ccatgaactc     2340

agccttcagg aataccagag agttcatata ctcaggtttt gtgacctaag tggcaataaa     2400

gagtggtggt tagctgaagc tcaagggcag aaaggatacg tgccagctaa ctaccttgga     2460

aagatgactt atgcttaaga aaataagcct tcaactttta ttttccagca agttgttgat     2520

tgactacctc ataaaactga cattacaaaa ctttggacca gaaagcaaga aacctctgaa     2580

ctacagaaac tgatactgta ctgggttttc aggaatactg tacttcctaa caggattatt     2640

gcatgaatgt attataaagg atacatgttg aaagaaatac taagccaaca gaaatagcaa     2700

agcaaatgac ccaagcttca actatcaact atttaaaagt gaagatcttt tgaaggagta     2760

attatattct tttatcatca agaaaggttg gatccaaagg tttttcaatt tacttttttt     2820

tttactgtat gatgtatttt gccttaaatg tttttgtttt tcatattgct ctcttgcaaa     2880

tgcatacatg tttatataca tacatataaa ccatatatat tatgtagctt tatacacgta     2940

tgtggataat atgaattata cacctatatg tataaatcag agtatacacc aaatatacat     3000

aagaagaata taccaccaac tagaagtctt tgataatata ttttgttaat gtttcgttta     3060

tatgttttga actaaaactg aataacttga tattaacatg taacattact gaatgcacac     3120

tatatgccag acattgttct aagtgcttta tatgtagtaa cttgtttaat attcaaaaca     3180

ttatgaagaa accatggccc aaaaaggtga agtaatttaa tccaaatcac attgctatta     3240

agtggtgggc ctggacttaa acctaggtag tgtaaaccaa aaataaaatt ctaaggcttc     3300

caaccatcta aatagacttc cccttcagcc agggcttttt tctttctttt cttgttgttt     3360

tttttttttt ttaaagagac aataaaagga ggttttttta ttcaaaggta taactggata     3420

agtagatttg tttacaatca ttcttgtgaa atactttttt aaaaaaatac gatcaacttc     3480

tttgcaaata gtagacacat acctcaacaa tgatgaccta atttttgatc cataatgtaa     3540

gattaggtag aaataggcaa gctcacactg ctaaattaac tatcaaatac tcagtcaaaa     3600

ctccatttgt ggcccccact tcttgatcta tttctgttcc acttcgtctt ctaccatctt     3660

gccgactttc ctgagcaact gctttgtcga ctctctctac ctgaccaatt gccagatcga     3720

caacctgact ggcctgacca gccactcctc tgtctggaat taaaagatgt ttccatcata     3780

atattcttta atttcaggta atttagctgg cactgagagt atccagccgg aatcatgcca     3840

ctttgcctgt aacctttgac tcaattggag gaatatcaaa gcaaacaccc atatttcctt     3900

tcaggaggca cactctggta atctgagaca ctgcattact attcagcttt ctaagttctt     3960

tccaagcaca gctgacatcc tgtatttcct ctaggctttc cagagtcatg gtcacaaacc     4020

ccttatcaga gttgattaaa gatcatggtt caaagcttga tacaccagaa atgtgggcta     4080

aagctgcagc caatgcatct atcgcccctt tctcttctat cagtatctga gctgatggtt     4140

ggaaaaaaat caacagcagc ataagaaatg gaagccagag accttatggc atccatgctt     4200

ttaaatttaa ctaaatccat tgtagaagga acacctacac atttaaaagt aatttgtgtt     4260

ttttgttcca catgtcttag ttgacctttc tcttggttga taaaaacata tacaaacccc     4320

tgtctgtcca gctttaccca cgcatccaga gagatggata taggactcaa tatcctgagg     4380

aggagaactt tgaatcacca ggtcaactac aggaatgtcc aaaccacgag gagccacatt     4440

ggttgccacc aaaactttat aattacctct ctgaagcctt ttagtgtaat ttctctttgt     4500

gactgtgcaa tgtccccatg taaacacagt gcattctgtt ttgtgcggat tcatggccat     4560

gtcagttaca ttcttcttcg tctcacagaa aataatagcc ctcccttcag atccactgta     4620

gacttgaagg acatctcatt ttcatctgtg ttttataaag gaggaaattg aggacctcac     4680

atggagggac tggaatttaa aaccaggtct tctgacttta aggcctttct tttagtgttt     4740

tcccttttct tttccttaag tcactaaaat ctgtagttat ataatcttac ataaagcata     4800

tgcaaaatag aaaaatgata gtcaccacat atctactaat gggattaaaa tgtacaatcc     4860

taaaagctta cttgttagca cacttgctta tctgtccatt cattcattga accagtaagt     4920

atttattgag agttagtggg aatacaatgc tgtgcaagac aaacaagatc cctccattca     4980

taccacttaa attctagtgg ggaaaacatc tgcacataac aaactaaata aaatgatcat     5040

aaaataataa atgctattta tataaaactg gctactttca ttactgctca gttaaagggt     5100

cttgtagctc attttatgac atgaaaaaaa tcaaggtcta aaagctcctt gagacaattt     5160

aaactctaat accaaatata cctctataaa ataccaaact gagctaaata cggtatatgt     5220

gtacttatac atatgtacat aacctaaata tacgtgtgca cacattatct atacaaagag     5280

ccatactcag tgaaagataa attacctcct aaactaaagt cccctctgag gtacaacaga     5340

aattaaaata attgcttctc ttctcaactc tatgtagcac gtattttcca tgatgggata     5400

aatgttttca tttcaagtgc caatgtgtga actgtaataa acattactgc tttc           5454


<210> 2882
<211> 538
<212> DNA
<213> Homo sapiens

<400> 2882
cttcacagcc taaaagcttt gaaaattcac ctggagattt gggtaattcc agccttccta       60

cagcaggata taagcgggct caaacttctg gcatagaaga agaaactgta aaggaaaaga      120

aaaggaaagg aaataaacaa agtaagcatg ggcctggcag acccaaagga aacaaaaatc      180

aagagaatgt ttctcatctc tcagtttctt ctgcttcacc aacatcatct gtagcatcag      240

ctgcaggaag cataacaagc tctagtctgc agaaatctcc tacattgctc aggaatggaa      300

gtttacagag cctcagtgtt ggctcatctc cagttggttc agaaatttcc atgcagtatc      360

ggcatgatgg agcttgccca acaactagta tttataacag caatgatgta gcagtatcgt      420

ttccaaatgt agtatctggc tcgggatcta gtactcctgt ctccagctct cacttacctc      480

agcagtcttc tgggcatttg caacaagtag gagcgctctc tccctcagct gtgtcatc        538


<210> 2883
<211> 795
<212> DNA
<213> Homo sapiens

<400> 2883
gtttaacagc tggcccggaa gtttaagtga atatgcggct tgggctccaa aagttgctgt       60

acggtatttt attttaaagt agaaatctgt ccgcttttca cttacggagg ccttacagtg      120

tgtgttctgt gttacttgag tttatacgca ctgcagaatt tgtttaccct gctcttttgg      180

aaacgtattc cggaagcgaa accctgagta atcggaagtg gttaggagtg agagagctgc      240

tggatatgcg gagggactgg gcgggtcggc ttccgaatgg aagaggtctg tgagaagtta      300

acctggtgat accgatccga agagcctatc aagtgaagcc ccctgaaata cggagaataa      360

gaatcttaga gcagaagtct tggagtgcat tttcagtggt taaggtgaaa aaatgactac      420

taaaaattta gaaaccaaag tcaccgttac ttcatcccca atccgaggag caggagatgg      480

aatggaaact gaggaaccac ctaaatctgt tgaagttacc tccggagtcc aatctagaaa      540

gcatcatagt cttcagagtc catggaagaa agcagttcca tcagagagcc caggagttct      600

tcagctaggg aaaatgctca ctgaaaaagc aatggaagtt aaagctgtaa gaatattagt      660

tcccaaagct gctataactc atgatatccc caacaaaaat acaaaggtta agtctctggg      720

acatcataaa ggagaattcc ttggtcagtc agagggagtt atagaaccta ataaggaact      780

ctcagaggta aagaa                                                       795


<210> 2884
<211> 4086
<212> DNA
<213> Homo sapiens

<400> 2884
atcactccta gctgctcagc aaaccactga ggttcctggg aaaaaaaaaa aaatatctca       60

agggtgtgtt aacttgggac actcgttaac tgggggacct tcttgaggct tttttccttc      120

tttttaaaaa tcatctttga ttattcttct tttctagtaa aataatattt agaaaaaata      180

atgtcagagc acagcagaaa ttcagatcaa gaagaacttc tcgatgagga gattaatgaa      240

gatgaaatct tggccaactt gtctgctgaa gaactgaaag aactgcagtc ggaaatggaa      300

gtcatggccc ctgaccccag ccttcccgtg ggaatgattc agaaagatca aactgacaag      360

ccaccgacag gaaacttcaa tcataaatct cttgttgatt atatgtattg ggaaaaggca      420

tccaggcgca tgctggaaga ggaacgagtt cctgtcacct ttgtgaaatc cgaggaaaag      480

actcaagaag agcatgaaga aatagaaaaa cgtaataaaa atatggccca gtatttaaaa      540

gaaaagctca ataatgaaat agttgcaaat aaaagagaat caaagggcag cagcaatatc      600

caagaaacag atgaagaaga tgaagaagaa gaagatgatg atgatgacga cgaaggagaa      660

gatgatggtg aagagagtga agaaacgaac agagaagagg aaggcaaagc aaaggaacaa      720

attagaaatt gtgagaacaa ctgccagcag gtaactgaca aagcattcaa agaacagaga      780

gacagaccag aggcccaaga acaaagtgag aaaaaaatat cgaaattaga tcctaagaag      840

ttagctctag acaccagctt tttgaaggta agtacaaggc cttcaggaaa ccagacagac      900

ctggatggga gcttgaggag agttaggaaa aatgatcctg acatgaagga actcaacctg      960

aacaacattg aaaacatccc caaagaaatg ttactggact ttgtcaatgc aatgaagaaa     1020

aacaagcaca tcaaaacatt cagtttagcc aatgtgggtg cagatgagaa tgtagcattt     1080

gccttggcta acatgttgcg tgaaaataga agcatcacca ctctcaacat cgagtccaat     1140

ttcatcacag gtaaagggat tgtggccatc atgaggtgtc tccagtttaa tgagacgcta     1200

actgagcttc ggtttcacaa tcagaggcac atgttgggtc accatgctga aatggaaata     1260

gccaggcttt tgaaggcaaa caacactctc ctgaagatgg gctaccattt tgagcttccg     1320

ggtcccagaa tggtggtcac taatctgctc accaggaatc aggataaaca aaggcagaaa     1380

cgacaggaag agcaaaaaca gcagcaactc aaggaacaga agaagctgat agccatgtta     1440

gagaatgggt tggggctgcc ccctgggatg tgggagctgt tgggaggacc caagccagat     1500

tccagaatgc aggaattctt ccagccaccg ccacctcggc ctcccaaccc ccaaaatgtc     1560

ccctttagtc aacgcagtga aatgatgaaa aagccatcgc aggccccgaa gtacaggaca     1620

gaccctgact ccttccgggt ggtgaagctg aagagaatcc agcgcaaatc tcggatgccg     1680

gaagccagag aaccacccga gaaaaccaac ctcaaagatg tcatcaaaac gctcaagcca     1740

gtgccgagaa acaggccacc cccattggtg gaaatcactc ccagagatca gctgctaaac     1800

gacattcgtc acagcagtgt cgcctatctt aaacctgtgc aactgccaaa agaactggcg     1860

taagaggcaa cagagccatc tagaagaaca agaaatggaa atagtgactc ttggattaca     1920

gcatggagac tatgtcagca gcaatacttt aggatccacg tggcagaact ggaaacaatg     1980

ctaccatctg ataagggtat ttgtaaaagg cagaatgttt gggccatgaa gaagtagggg     2040

ctgaagagga aggtggaagg agataaaata taatatttag aggcaatatt ttctacttgc     2100

aatcaatttg agtgactcag gtgaaattta gagtcatatt tcccgaagca gaagttaaag     2160

aaaatttttt aaacatttgc tttattattg ttttcttctg gtaaataata aatataacag     2220

aagtgttaac tattgtattc ccattttttt ctccttccat ctcttctgcg gtaattcatc     2280

acatagtatc ttaaagggaa caaataatgt ttcatcctat ggaaatgtga aggatgaatt     2340

gagctcctgg cccttctgat gctttgaaat ggaaggattg ttccttagag cttctctgca     2400

gaatcagtgg agattttcag tttcccaccc tgcctggctt tctctcttgg tgactccctt     2460

ggtgttttgg agtattcttt ctataggggt acctgtgagg ggcagaacac gtaagccaca     2520

gaacatggtg aaaactaagt gtcactagga aaagtaatgg gaaagtaaac cctgcatata     2580

tgaaaacttc ctggcagcaa gttttcatat atagagggac aatgggagac agcatgctgt     2640

ttttatagaa aagaagtttt acataatata gttattgaca agcttttggt tttggctaaa     2700

tacacacaca cacacacacg ctcatatgtg tttactctgt aagtctaatt tgattttatc     2760

actctcaaac atattttaaa ggaaacttgc ttacaggaag gattaaactt gaactactta     2820

tcctattctt taaggcactc cattgcctgg ccccaattta ctaatcctgt cttatttccc     2880

acaaatcctt tatactctac tcgatgaaac atccttgtgc acacccttgt gcctttgctc     2940

gcattaatcc ttccaagaga cttccctcct gttctccatt aatgaacgtc ctacccagtc     3000

ttcaactccc gggtcagatc ctgtgtcctc cataaaaaat tttccagaca actccaatct     3060

gtccttcttc caagttccta gaggccttaa ttattcattc tagccactag gtgcatagaa     3120

tttgagattt ttgtaataat agaagtagtg tgaaccctag aaattagaaa atcaagcttt     3180

gggccaggtg cggtggctca tgcctgtaat cccagcacta tgggaggcca gggagggagg     3240

atctccagag gtcaggagtt cgagaccagc ctggccaaca tggtgaaacc ccgtctctat     3300

taaaaataca aaaattagct gggcatgatg gcaggcacct gtaatcccag ctactcggga     3360

ggctgaggca ggagaattgc ttgaactggg gaggcagagg ttgcagtgag acaagatcac     3420

gtcactgtac tccagcctgg gtgacagagt gatactccat ctcaaaaaaa aaaaaaaaaa     3480

aaaaaaaaaa aaaaaaaaaa aaaacctttg gtgccttttc tctcttcttt acctgagtaa     3540

ataattggca cctgccttct ttctcctttt atgttatcat aagtggcatg tatcaaacca     3600

aacaggctag gggagaatag gtctaattgt gacagactta aaaacaacac attatttgga     3660

aagacaagcc atgggaaaga aatatggcgt ttctattttt ttaagataat ttagtatgta     3720

caaaagtatc caaatttaaa tatagttttc aatggctgat agttttgttt tctcaccctt     3780

caatatttct agaaaacatc cttgcataca aagcaggata gctaagaaag ggctgtaaca     3840

aacaaaactt caagtgtcta gcacatacta catctaagag gctaaactct gataggaaaa     3900

gcactttaaa cataattaaa agcttaatgt aaattagtag ttgaaattct aggccggtgc     3960

ggtggctcat gcctgtaatc ccagcactgt aggcggccga ggtgggtgaa tcacatgagg     4020

tcaggagttc aagaccagcc tgaccaacat ggtgaaaccc catttctact aaaaaaaaaa     4080

aaaaaa                                                                4086


<210> 2885
<211> 134
<212> DNA
<213> Homo sapiens

<400> 2885
ctggagtgct gctttcctcc gaattagcaa atctggtttg ccaacacagt atctgccttc       60

caggggattc cttaccccat caccatgtgc acctcagaaa ctttccaagc gctggacacc      120

ttcgaagcca gaca                                                        134


<210> 2886
<211> 903
<212> DNA
<213> Homo sapiens

<400> 2886
gtgctccccc gccccgcgta gcggcggtcg ccgccaccgg cgcctccacc tctaccatct       60

cctctttctc caccacctcg ggccccggtg tccccggcca gcactatgcc catcttactg      120

ttcctgatag acacgtctgc ctctatgaac cagcgcagcc atctgggcac cacctacctg      180

gacacggcca aaggcgcggt agagaccttc atgaagctcc gtgcccggga ccctgccagc      240

agaggagaca ggtatatgct ggtcactttc gaagagccgc cctatgctat caaggctgga      300

tggaaagaaa accatgcaac gtttatgaat gaattgaaaa accttcaggc tgaaggactt      360

acgactcttg gccaatccct aaggacagct tttgatttat taaatttaaa tagattagta      420

actggcatag acaactatgg gcagggaaga aacccttttt tcttggagcc agcaataatt      480

atcacaatta ctgatgggag caagttgact accaccagtg gagtccagga tgaggccgtt      540

catattctgt gtgttctcca agaatgctta atcagtgtct ggagtccttg gtgcagaaag      600

tacaaagtgg ggtggtaata aactttgaaa aagcaggacc agatccttcc cctgtagaag      660

atgggcagcc agatatatca aggccttttg gatctcagcc ttggcatagc tgtcacaaac      720

tcatatatgt cagaccaaat cctaaaactg gggttcctat aggtcattgg cctgttccag      780

agtctttttg gccagatcaa aattcgccaa cactaccacc tcgtacatct catcctgtag      840

tgaagttttc ctgtacagac tgtgaaccaa tggttattga taaacttcct tttgacaaat      900

atg                                                                    903


<210> 2887
<211> 507
<212> DNA
<213> Homo sapiens

<400> 2887
aggaaaactg cagacagaaa aatgtggccg gatgctctgt gggcgggcgg cagcgatgtt       60

cggccaggtg gctccaagga gaggaagcag tgatgcattg agggagtaaa catggaatcg      120

gtgagaatca ctttccttga tcattatgtg gtcagtatgc ggtgactgac ttgatgtgac      180

tggggaaggt cccttccctg gacagaatat ggtgagtgtc gtgccattac cggagaggat      240

caccttccct ggccacatgt ggtaaaaata agtgactaaa gaagcagacc tgggaatcac      300

ctaacatgtc gaggaggaga tttgattgcc gaagtatttc aggcctacta actacaactc      360

ctcaaattcc aataaaaatg gaaaacttta ataatttcta tatacttaca tctaaagagc      420

tagggagagg aaaatttgct gtggttagac aatgtatatc aaaatctact ggccaagaat      480

atgctgcaaa atttctaaaa aagagaa                                          507


<210> 2888
<211> 4288
<212> DNA
<213> Homo sapiens

<400> 2888
ggccattttt cttcctggtg tttgaatgac tcataaaatg agtttggagt ggtctgaagc       60

ctctgcctcc ttccttgaat gctttctaag aggggctgcc atgcaagaat atatgctgat      120

tttcccatac ggcgcctcat ctcccagaga tcttccttgg agaccctgga agatattgag      180

gagaacgccc ctctccggag atgtcgaact ctctcaggtt cacccagacc aaagaatttt      240

aagaagattc attttatcaa gaacatgcgg caacacgata ccaggaatgg cagaatagtc      300

cttatcagtg gcagaagatc cttctgtagt atattttcag tgctgccgta tcgcgacagt      360

acccaagtcg gggacttgaa gttggacgga ggaagacaat caactggtgc agtgagtttg      420

aaagagatca ttggtctgga aggtgtggag ctgggtgctg atgggaagac tgtttcctat      480

acccaatttc tgttacccac aaatgccttt ggagcccgga gaaataccat agactccacc      540

tcctctttct cccagttccg taacctgagc caccgcagcc tctccatagg ccgggcaagc      600

ggcacccagg ggagcctcga cacaggtagt gacctgggag actttatgga ctatgaccca      660

aatctcttgg atgaccccca gtggccttgt ggcaaacaca aacgcgttct gatcttccct      720

tcctacatga caacagtgat tgactacgtg aagccctcgg atctcaagaa ggacatgaac      780

gagaccttca aggagaagtt tcctcacatt aagctgacac tcagcaaaat taggagtctg      840

aaacgagaga tgcggaagct tgcgcaggag gactgtggcc ttgaggagcc cacggtggcc      900

atggccttcg tctactttga aaagctcgcc ctcaagggga aactcaacaa acagaaccgg      960

aagctgtgtg ctggggcatg tgtgctgtta gcagccaaaa ttggaagtga cctcaaaaaa     1020

cacgaagtca agcatttaat tgacaaactg gaagagaagt tccggctgaa caggcgagaa     1080

ctgattgcct ttgaattccc ggtgttagtg gccttggaat tcgccctcca cttgcccgag     1140

cacgaagtca tgccccacta cagacggctg gtccagagtt cctagcactg gccccgagga     1200

cagccaaggg ccatttcttc tcagcttggt ggagcagcac ttacttacta ctggaaatga     1260

aaaaaagtag aactcagaat accagacttt tcttcctctc gacatagttt ggggagaagc     1320

agtactagaa actttccaag gagtcttggg tgtgtagcca agaggagcca tgagctatgg     1380

actcctcaag cacgggaaga ggaggtgtgt gctgagaaca gagaggccct gccctctgtc     1440

cactagcgag aatccctagc tgccccagcc cagtctttct ccccggcatt cacaaacttt     1500

gcaagcgtgg tccagggcct tctccagatc tgttccaact tggagtgtga agggcttgag     1560

catacggggg aagagagtct gcagaagttg ggggaaaact tttaaaagat accctcattg     1620

tgtcaaagag tgtgccaatc tatttttgta tcagcattgg aagtgcactt tcccctgggg     1680

cgtgtgggtg tgtgaatgtg caagtgtctg agagatactg catcagccct agacccccag     1740

agccagtccc gccctttaca gagcagccct tagcctgggg ccatgggtca ggctgacctt     1800

caacaattat ttctagatga tttctggata agaattgctc tctcggtacc agacagtttg     1860

acatcctcca cccttagaaa atgactgaca ttgttttgtt actgctccta cccaccaagg     1920

ggataaagaa ggcgagttct gagtgttgga tgagtcagtc gcgtggaagg acgtggagcg     1980

tggcgctctg taacttcctg ccgtctgcca ccccgccacg tgtatttaac cctcgcactt     2040

tctccactgt ggagatggct ggggcggcgc cccacagtgt gtattcctgt cctctatgtt     2100

agagtgcatc agaagcacat ttactgtgct atctatatcg ctatataaaa gtgttttata     2160

aaaacccaga ataggagcac gacgcatgat tggtgtttga ggcgtttgcc agctgggaca     2220

aactgcgttt ggagctgtgg ttaagctgac taaggaggcg gtggctcttt cttaacattc     2280

ccacgtgccc agggctgttc atgcaagatt ttaatggtga cttgtcctgg cttactggga     2340

cagtctgtat gaggcatgtc accacactgt cgcctcatag ctgcaagaga gaggcaccag     2400

ctgaagttcc cctgactgaa gagagcctgt ggccatgtaa aaagagaatt aaactcttgt     2460

tgctttttgt atacctgtat gcgtttgtgt agacgtgtgt ctcaccagtc acctttgccc     2520

tgcattgctg atccccttgc gcacactgat tctagtgagg tcacagattc ggagcttcac     2580

acaccagccc agagaaaggg cgatggaacc gaaccgaggg tctgcagctt tcgttagcag     2640

agctgtcaga ttcttgacag tcttggagga tggagaaatt caagcagcag ctggtgaggg     2700

ccaaaacaga atacttggct tcttcagaat cttagattgc actgagttta gtcctaaata     2760

ttttgctaac aaatttcctt ggccagaatc agttgtaaga cagtgatttg ggtggtgggg     2820

ggagggagga gggagaggat atgattaatg tggtctcttt ggctgatcga aagctagatc     2880

aactggtact tagggcactt gctgtttata aagcaaaatt gagaaaatat tcaaggtgcc     2940

tccatcgcct gaactacaaa atgcccttgg ccttcctcac atggggtctg tcaccttgca     3000

tctctgataa gccatccacc ttcctggtca gtgcctacag ggggagagcc tttctgagaa     3060

gcaggtcctg tggtatctga gaatggtcta gagagctccc cactgcccat ctgcccccga     3120

atttcctgcc aagctctggg gagtggggtg gggggaggga cgtccgatgg atgacaggcc     3180

gccagcccag acgtggggag agaagcctga gtcctttcct gtgtgataaa atcaggctaa     3240

tttacttgga tttggggtga tttgtttggt ttttagcatt tatgaggtga gcccatgaag     3300

ttagtggtcc attacttttt aaagatgcat tttcatttta aactgtctcc tggcctgtgg     3360

atttgtggaa tggacagttt tgtgggtttt aatttatttg tgaggagtcg gggctgagaa     3420

ggcattttat caggaggtct ccttttgcac gtccatgaca tgagcttttc ggaggcaaag     3480

gaagtggagg agggtgagag atgcaggtca ctgccagagg cacctctgtg acacggaaca     3540

ttccagacac gtcgcagcct tgggcttcgg cgaggaggaa gtctgagcct gtgaagcgag     3600

aaggccaggc agtagactgg ctctgaggtt ttgccctttg acctcctcca cagagggcag     3660

cttcagcccc ttgtaagccc tgccccctct caggactgcc ctgaggcctc tccagtcctc     3720

cccacactca gagatctgtg gggaagctcc gcccagccac actccttggg ataatactag     3780

ccggttctgc ctgattcctt ttcccccgga gccagcctag ggggcccggg actcctctag     3840

tgagccttga ctgttaggta agagacagga agcagacaag ccaagaggtt gctgcagctg     3900

cccccaggag gaaacgggca gcagggagtg tggcccagcc cccactgtac ccctccaggg     3960

gcccgagccc ttgccagccc aatgacacct tgaagtcacc acttttcctt tcttgcccgc     4020

taataaaacc tatttaaaca ggaaattcat accaaatgca aatgggtttt gttttccttg     4080

gcattttgtt gttccgatca cagatttccc tgccagggtg tctgtggtta tcagctgcag     4140

gctcagcttg gggcggccgc ttcacacaag ccactctgta ccacgtgccc taccttagtg     4200

acgggagtaa ggagcttcct tcccctccat gtcattcctt cctgttccct tcattcccca     4260

acagcaaata aaactgttga atgctctg                                        4288


<210> 2889
<211> 1246
<212> DNA
<213> Homo sapiens

<400> 2889
aatctctgtc tggatacttt taggaaaaga accttgttat tatgtactaa agtgaataat       60

ttgtgctctt agagtaggag ttggaactat aggacttgaa ggcaagagca ggtatcttat      120

caaggatcta ctcactcagt ttccctaaag ctctctctcc agatcggatt caaccgcaca      180

tcatgacaga tgttccggct acatttaccc aggctgagtg taatggggat aaaccacctg      240

aaaacggtca acaaacaatc actaaaatca gtgaggaatt gactgatgtg gacagccccc      300

tgccacacta cagggtagaa cccagtctgg aaggtgcact caccaaagga agtcaggagg      360

aaagaagaaa attacaaggg aacatgctgc tcaactcatc catggaggac aaaatgctaa      420

aagaaactag tgctgatgaa atgacattca gagaagggca tcagtgggag aagattcctc      480

tgagtggcag taaccaggaa ataagaagac agaaggagag gattactgag cagcctctca      540

aagaggaaga agatgaggac aggaagaaca aaggtcacca ggcagctgaa attgaatggc      600

tgggatttcg aaaacctagc caagctgaca tgttacattc taaacatgat gaggagcaga      660

aggtttggga tgaagaaatt gatgatgatg atgatgataa ttgcaataat gatgaagatg      720

aagttcgagt gatagaattt aagaaaaaac atgaagaggt ttctcaattt aaagaggaag      780

gtgatgcaag tgaggactcc ccactgagca gtgccagttc ccaagctgtg acacctgatg      840

agcagccaac cttagggaag aagagtgata tctccagaaa tgcttattcc agatacaata      900

caatatccta tcggaaaatc agaaagggaa ataccaagca aagaattgat gaattcgagt      960

ctatgatgca tttataaact aactggaact gagaaattct catgcccact aaaggaaaag     1020

ctaattctat tgccccaggg tgcatatttc tatgccttat ttgagttatc acttggaggg     1080

aggtggaagt tgactctctt tttcactgta gaataatgtg gaaataaccc tagataaaaa     1140

ttcagtctga taacctcaaa tcaaaaagct ttaaataaat tcttgggcat ttatctttta     1200

aaacttcact aatatagcat tgtgtgataa gcactaagca gtcagt                    1246


<210> 2890
<211> 5697
<212> DNA
<213> Homo sapiens

<400> 2890
gattgggccg ctgtcaggtg tcgctgcctg caggttcggc tgcgcgagcg gagggaggcg       60

ggactcaaga gtagccttcc tcgaggacct gcctttccca tttgctgcct gaagttaatg      120

tttcttgctg gccaaatcag ggacatgccg gcattagcgg gatgagtggg tgttccggca      180

gggatgtggt cattgacggc cagtgagggc gagagtacca cggcccactt cttccttgga      240

gctggagatg aggggctggg cacccgtgga ataggcatga ggccagaaga gagtgacagc      300

gagctccttg aggatgagga ggatgaagtg cctcctgaac ctcagatcat tgttggcatc      360

tgtgccatga ccaagaaatc caagtccaag ccaatgactc aaatcctaga gcgactctgc      420

agatttgact acctgactgt tgtcattctg ggagaagatg taatccttaa tgaacctgtg      480

gaaaactggc catcctgcca ctgcctcatc tctttccact ccaaaggctt tcctctggac      540

aaagctgttg cttactccaa gcttcgaaac ccctttctta tcaatgatct ggccatgcag      600

tattacatcc aagataggag ggaggtgtac cggatcctgc aggaagaggg tattgatctg      660

cctcgatatg ctgtgctcaa ccgtgatcct gcccggcctg aggaatgcaa cctgatagaa      720

ggtgaagacc aagtagaggt caatggagct gtctttccca agccctttgt ggagaagcca      780

gtgagtgcag aagaccacaa tgtttacatc tactacccca gctcagctgg aggaggaagc      840

cagcgtctct ttcgtaagat tggcagccga agcagtgttt actctcctga gagcagcgtc      900

cgaaagacgg ggtcgtacat ctatgaggag tttatgccaa cagatggcac agatgtcaag      960

gtgtatacag tggggccaga ttatgcccat gctgaagcta gaaaatctcc agctttggat     1020

gggaaggttg aacgagacag tgaggggaaa gagattcgat atccagtcat gctgactgcc     1080

atggaaaagc tggtggccag gaaagtctgc gtagctttca agcaaacagt ttgtggattt     1140

gaccttcttc gtgccaatgg tcattccttt gtgtgtgatg tcaatggctt tagttttgtc     1200

aagaactcga tgaaatacta cgatgactgt gccaagattc tggggaacac cataatgcgg     1260

gagcttgccc cacagttcca gattccatgg tccatcccca cggaggctga ggacattccc     1320

attgttccca ccacatctgg cactatgatg gaacttcgtt gtgtcattgc aattattcgt     1380

catggggatc gtactcccaa gcagaagatg aagatggaag tgaaacaccc aaggtttttt     1440

gctctgtttg aaaaacatgg tggctacaag acagggaaat taaaactcaa gcgacctgag     1500

cagctccagg aggtgctgga tatcacaagg ctgttgttgg ctgaactgga gaaagaacca     1560

ggtggtgaga tcgaggagaa gactggaaaa ctagagcagc tgaagtctgt actggagatg     1620

tatggtcact tctcaggtat aaaccggaag gtacaattga cttactaccc tcatggagta     1680

aaagcttcta atgaggggca agatccacag agggaaactc tggccccatc tctgttgctg     1740

gtactgaagt ggggtggaga actgactcct gctggccgtg ttcaggctga ggagctgggg     1800

cgagcttttc gctgcatgta ccctggagga cagggtgact atgctggctt ccctggttgt     1860

gggctgcttc gtctccatag cactttccgc cacgatctca agatctatgc ctctgatgag     1920

ggtcgtgttc agatgactgc tgctgccttc gccaagggcc ttctggctct agaaggggag     1980

ctgacaccca ttttggtgca aatggtgaag agtgccaaca tgaatgggct actggacagc     2040

gatggggatt ccttgagcag ctgccagcac cgggtgaagg ctcggctgca ccatattcta     2100

cagcaggatg cgccctttgg ccctgaggac tacgatcagc tggctcccac cagaagtact     2160

tccctgctca actccatgac tatcatccag aatcctgtga aggtctgtga tcaggtattt     2220

gccctgatcg aaaacctcac ccaccagatc cgggaacgaa tgcaggaccc caggtctgta     2280

gacctgcagc tctaccacag tgagacacta gagctaatgc tacagcgttg gagcaagctg     2340

gagcgtgact ttcgacagaa gagtgggcgc tatgatatca gtaagatccc tgacatctat     2400

gactgtgtca agtatgatgt gcagcacaat gggagtctgg gacttcaagg cacagcagag     2460

ttgctccgtc tctctaaggc actggctgat gtggtcattc cccaggagta cgggatcagt     2520

cgggaggaga aactggaaat tgctgtgggc ttctgtcttc cactgttgcg gaagatacta     2580

cttgacctgc agagaaccca cgaggatgag tctgtcaaca agctgcatcc cctctgttat     2640

ctcaggtact cccgaggcgt gctctcccca ggtcgccacg ttcgaacgcg tctctatttc     2700

accagtgaga gccatgtcca ctccctgctc agtgtcttcc gttatggagg acttcttgat     2760

gagacccagg atgcacaatg gcagcgagct ttggattatc ttagtgccat ctcagagctt     2820

aactacatga cccagattgt catcatgctt tatgaggaca acacacagga tcccttatca     2880

gaggaacggt tccatgtgga gctacacttc agccccggag tgaaaggtgt tgaggaagaa     2940

ggcagtgccc cggctggctg tggattccgt ccagcctctt ctgagaatga ggagatgaaa     3000

accaaccaag gcagtatgga gaacctgtgt ccaggaaagg catcagatga accagaccgg     3060

gcattgcaga cttcacccca gcctcctgag ggccctggcc ttccgaggag atcacccctc     3120

attcgtaacc gaaaagctgg ttccatggag gtactttctg agacttcatc ctcgaggcct     3180

ggtggctacc ggctcttttc atcttcacgg ccacccacag aaatgaagca gagtggccta     3240

ggctcacagt gcacagggct gttcagcacc acagtgctgg gtggctcctc cagtgccccg     3300

aatcttcagg actacgcccg cagccatggc aaaaagctac cacctgccag tctgaagcac     3360

cgagatgagc tcttgtttgt cccggccgta aaacgatttt ctgtgtcgtt tgcaaagcat     3420

ccgactaacg ggtttgaagg gtgttccatg gtgcctacca tctaccctct ggaaacactg     3480

cataatgccc tttccctacg tcaagtgagt gaattcttga gtagagtctg ccagcgccac     3540

actgatgccc aggcacaggc atctgcagcc ctctttgatt ccatgcacag cagccaggcc     3600

tcagataacc cattttctcc accacgtact cttcattcac ctcccctgca actccagcag     3660

cgctctgaga agcccccttg gtacagcagt ggcccttcta gcactgtgtc cagtgctggt     3720

ccttcttccc ctactacagt agatggtaac tcccaatttg gcttcagtga tcaaccctcc     3780

ctaaattcac acgtggctga agaacatcaa ggccttgggc tgctccagga gacccctggg     3840

agtggagcac aagagctctc catagaaggg gagcaagagc tttttgaacc aaatcagtcc     3900

ccacaggtgc cacctatgga aaccagccag ccatacgagg aggtcagcca gccatgtcag     3960

gaggtccctg acatcagcca gccatgccag gacatttctg aggcgctcag ccagccatgt     4020

cagaaggtcc ctgacatcag ccagcaatgc caggagaacc atgacaatgg taaccacaca     4080

tgccaggagg tccctcacat cagccagcca tgccagaagt ccagccaact gtgccagaaa     4140

gtctctgagg aagtttgcca gctatgtctg gagaactccg aggaggtcag ccagccatgc     4200

cagggggtct ctgtggaggt tggcaagctg gtccataagt tccatgtagg ggttggtagc     4260

ttggtccagg aaacccttgt agaagttggc agcccagctg aagagatccc tgaggaggtc     4320

atccagccat accaggagtt ctctgtggag gttggcaggc tggcccagga gacttctgcg     4380

atcaatctgt tatctcaggg catccctgag attgataaac catcccaaga gttccctgag     4440

gagattgatc tgcaggccca ggaggtccct gaggagataa attagaagtc ctgggtggtc     4500

cctgaagtga ttgatcagct gcctggagag ggtattcctc aagcccagca tccatctggt     4560

gatccaaacc ctcagagcca gtctctagcc catgaccagc actcacccct tccaccagca     4620

acatgtgatt aattttctca ttagtggtat cacactatac cagccatttg agccagcaac     4680

cttttctgtt ggctaactca ctggccagct ctcaccagcg gtgtctgggg aagtagttct     4740

ctttgtatga agcatacctg tgccagagct gtggttgagg aggagccagt tttaggttcg     4800

aagaagccat tggctcctca cttagccatt agacttgaat aggatttcct tggggtgggt     4860

tggtctgtca ttacccagcc ttctctgagc atcctaggaa atcacagatt gttaaaggaa     4920

atgccgcttc actgctgaag acaccatctg gcgacagcaa atgcaaaaga ggggactcta     4980

gggtcttcac ttttctgggg aaatgttcac gacttctcaa ggtacgctta gaccatatgt     5040

gcattcaggg gactcttgtc tttgccagca ctcctcaggt gagcccggga tggctatctg     5100

aaatgtctgg aaaatagagt cccttcccca aacatctgac atggccacta aatctttaga     5160

cttgccttat agatccttcc atatcatccc caagtgcccc ttctgcctca gtcctgttcc     5220

tctgggcaat agctctaggg aaaagtaggt attagactgc tgtgcaaaat tcagagcaac     5280

tacttaaaat gctctagagg attcttagcc agtctgtgaa agtgggcctc ctctgtggtg     5340

gggctgtttg gcttaggaga tgctgtagta gtagagataa tcaggttcta ttttaagcaa     5400

tcagcagaga tcaatattgt acagatacaa gcaaaggttt aataaatata tatatatata     5460

tttatttctg tagttgtgcc agggacagac tggccaaaga ccaaacactg cagggtcccc     5520

aagaaatttg tccttatatc attgtgtctg agggccagat atgattatga agctttttcc     5580

aaagatccag ggatgggaat gggagtgggt aggaggggta atgcggtcat tggagtcggg     5640

ggctggaaca ttatgagtgc tcaataaata taaactaatg agaatggtgg tgatgga        5697


<210> 2891
<211> 1287
<212> DNA
<213> Homo sapiens

<400> 2891
agactacccg ggccctcaca gaaggcggtg gcgggcgggt gcagcgagtt tgtccccttg       60

cccgcacact gcttggcctc tgtacttaag tgcggtggcc gcctgcctcg ctggagcttc      120

tctgccgcag ccatccgtgc tgcttgggac gggccggggc gcgaaggcgg tcgcatccat      180

cgctctgccc tcctgcttct cttgtgtaat cagctgccta tttggaaatt gggcagggtt      240

tgcgactgga tgctaatgtc actgactagt tttcagccta ccatccagaa gtaacatgtt      300

cccagctttg gaaacgcacc taaagcagac tattcctgat ccttatgaag actttatgta      360

ccgtcacctc caatattatg gctactttaa agctcagaga ggcagtttac caaactctgc      420

tacgcatcag catgttcgga agaataaccc tcaatgcctg ttgaatggct ctcttgggga      480

aaaagatgat ttgataccag acaccctgca aaaggagaag cttctatatt cacatatgct      540

gagtttacca catcttagga gcagacagct tctttatgat gagttggatg aagtaaaccc      600

acgtcttcga gaaccccaag agctcttttc cattttgtct accaagaggc cactgcaggc      660

tccaagatgg ccaattgaat gtgaggtcat caaggaaaac atccatcata ttgagtgggc      720

tccacctcaa ccagaatatt tctatcagcc taaaggaaat gaaaaggtac cagagattgt      780

aggagagaaa aaaggaacag ttgtctatca attagattca gtgcctatag aaggttccta      840

ttttaccagt tccagagtgg gaggcaaacg aggaattgtc aaggaacttg ctgtcacgtt      900

gcaaggacca gaagataata ctctactgtt tgaatcaagg tttgagagtg ggaatctgca      960

aaaagctgtc agagtagacc ctatgagtat gaactcacct tgcgaactga cctctacact     1020

aacaaacaca ctcagtggtt ttattttcgt gttcagaaca ccagaaaaga tgctacctat     1080

cgcttcacca ttgtcaactt gctaaaaccc aagagtcttt atactgtagg gatgaagcca     1140

ctcttgtact cccaattgga tgccaacacc cgcaatattg gctggaggag agaaggaaat     1200

gaaatcaagt actacaagaa caacacggat gatgggcagc agcccttcta ctgtctcacg     1260

tggaccattc agtttccata tgaccag                                         1287


<210> 2892
<211> 1293
<212> DNA
<213> Homo sapiens

<400> 2892
gttgctaccg gaatgcctct tcaggttagc gattacagct ggcagcagac gaagactgcg       60

gtctttctgt ctctgcccct caaaggcgtg tgcgtcagag acacggacgt gttctgcacg      120

gaaaactatc tgaaggtcaa ctttcctcca tttttatttg aggcatttct ttatgctccc      180

atagacgatg agagcagcaa agcaaagatt gggaatgaca ccattgtctt caccttgtat      240

aaaaaagaag cggccatgtg ggagaccctt tctgtgacgg gtgttgacaa agagatgatg      300

caaagaatta gagaaaaatc tattttacaa gcacaagaga gagcaaaaga agctacagaa      360

gcaaaagctg cagcaaagcg ggaagatcaa aaatacgcac taagtgtcat gatgaagatt      420

gaagaagaag agaggaaaaa aatagaagat atgaaagaaa atgaacggat aaaagccact      480

aaagcattgg aagcctggaa agaatatcaa agaaaagctg aggagcaaaa aaaaattcag      540

agagaagaga aattatgtca aaaagaaaag caaattaaag aagaaagaaa aaaaataaaa      600

tataagagtc ttactagaaa tttggcatct agaaatcttg ctccaaaagg gagaaattca      660

gaaaatatat ttactgagaa gttaaaggaa gacagtattc ctgctcctcg ctctgttggc      720

agtattaaaa tcaactttac ccctcgagta ttcccaacag ctcttcgtga atcacaagta      780

gcagaagagg aggagtggct acacaaacaa gctgaggcac gaagagcaat gaatactgac      840

atagctgaac tttgcgattt aaaagaagaa gaaaagaacc cagaatggtt gaaggataaa      900

ggaaaacctg aaagatgtct gaaaattcca gtgacagtga ttcatcttgt ggttggactg      960

tcatcagtca tgaggggtca gatatagaaa tgttgaattc tgtgaccccc actgacagct     1020

gtgagcccgc cccagaatgt tcatctttag agcaagagga gcttcaagca ttgcagatag     1080

agcaaggaga aagcagccaa aatggcacag tgcttatgga agaaactgct tatccagctt     1140

tggaggaaac cagctcaaca attgaggcag aggaacaaaa gatacccgaa gacagtatct     1200

atattggaac tgccagtgat gattctgata ttgttaccct tgagccacct aagttagaag     1260

aaattggaaa tcaagaagtt gtcattgttg aag                                  1293


<210> 2893
<211> 582
<212> DNA
<213> Homo sapiens

<400> 2893
ttttcggagg ctgccagcgt cccacaccag ccgcaggtga aaaccggcag aaagacatta       60

agagattttc ctgcagtcac tgctggcaga tgatagagcc aggatttgaa agcaggcagc      120

ctggctccag accctgtgct cttaactccc gttttgcatc aagaacagaa tcctatgaaa      180

ggcttgcaca gtgcttggta ctgagtaggc actccgatag cagcatcaag gagcattgtg      240

tacatgcaga agtgcacagt acctggagtg aaactgcttg tgttcgattt ctgataccat      300

tcataactgg ctgtgtgatc tcaaataaga aaactgaaga accagctggg cgcggtagct      360

cacgcctgta atcccagcac tttgggaggc tgaggcgggt ggattacctg agaacctcta      420

aaatgcagac ctccagctct agatctgtgc acctgagtga atggcagaag aattacttcg      480

caattacatc tggcatatgt accggaccga aggcagatgc ataccgtgca cagatattac      540

gcattcagta tgcatgggca aactctgaga tttcccaggt ct                         582


<210> 2894
<211> 2423
<212> DNA
<213> Homo sapiens

<400> 2894
atggtaacga cgctcggccc gaagatggcg gccgaatggg gcggaggagt gggttactcg       60

ggctcaggcc cgggccggag ccggtggcgc tggagcgggt ctgtgtgggt ccgaagcgtt      120

ttactcctgt tgggcgggct ccgggccagc gccacatcta ctcccgtctc cttgggcagt      180

tcccctccct gccggcacca cgtcccctct gacactgagg tcataaataa agttcatctt      240

aaggcaaatc atgtggtcaa gagagatgtt gatgagcatt taagaatcaa gactgtctat      300

gataaaagtg ttgaagagtt gctccctgag aaaaagaatc ttgtaaagaa caagcttttc      360

ccacaagcga tttcttattt agagaagact tttcaggtcc gtcgacctgc gggcactatc      420

ttacttagca gacaatgtgc aacaaaccaa tacctccgga aggaaaacga tcctcacagg      480

tactgcaccg gggagtgtgc cgcacacaca aagtgcggcc ccgttattgt tcctgaggaa      540

catctccagc aatgccgggt ctaccgtggg ggtaagtggc ctcatggagc agtgggtgtg      600

ccagaccaag aaggcatctc agatgcagac tttgttcttt acgttggtgc tctggccacc      660

gagagatgca gccatgaaaa catcatctct tatgcagcct attgtcagca ggaagcaaac      720

atggacaggc caatagcagg atatgctaac ctgtgtccaa atatgatctc tacccagcct      780

caggagtttg ttgggatgct gtccacagtg aaacatgagg ttattcatgc cctgggtttc      840

tctgctgggc tgtttgcatt ctaccatgat aaagatggaa atcctctcac ttcaagattt      900

gcagatggcc tcccaccttt taattatagt ctgggattat atcaatggag tgataaagta      960

gttcgaaaag tggagagatt atgggatgtt cgagataata agatagttcg tcacactgtg     1020

tatctcctgg taacgcctcg tgttgttgag gaagcacgaa aacattttga ttgtccagtt     1080

ctagagggaa tggaacttga aaatcaaggt ggtgtgggca ctgagctcaa ccattgggaa     1140

aaaaggttat tagagaatga agcgatgact ggttctcaca ctcagaatcg agtactctct     1200

cgaatcactc tggcattaat ggaggacact ggctggtata aagcaaatta cagcatggct     1260

gagaagttag actggggccg aggaatgggc tgtgactttg tcaggaagag ctgtaaattc     1320

tggattgatc agcagagaca aaagagacag atgctgagcc cttactgtga cacgctcaga     1380

agtaacccac tgcagctaac ttgcagacag gaccagagag cagttgccgt gtgtaatttg     1440

cagaagttcc ctaagccttt accacaggaa taccagtact ttgatgaact cagtggaata     1500

cctgcagaag atttgcctta ttatggtggc tccgtggaaa ttgctgacta ctgccctttc     1560

agtcaggaat tcagttggca tttaagtggt gaatatcagc gcagctcaga ttgtagaata     1620

ttggaaaatc aaccagaaat ttttaagaac tatggcgctg aaaagtatgg acctcattcc     1680

gtttgtctaa ttcagaaatc agcattcgtt atggagaagt gtgagaggaa gctgagttac     1740

ccagactggg gaagcggatg ctatcaggtt tcttgttctc ctcaaggtct gaaagtttgg     1800

gtccaagata cttcatattt gtgtagtcgg gctgggcagg tcctccctgt cagtatccag     1860

atgaatggct ggattcacga tggaaacctg ctctgcccat catgttggga cttctgtgag     1920

ctctgtcctc cagaaacaga tcctccagcc actaacctga cccgagctct gccacttgat     1980

ctttgttcct gttcctcgag cctggtggtc accctctggc ttctgctagg caatctgttt     2040

cctctgctgg ctggatttct tctgtgtata tggcactagg aatggaaaag tggatcttca     2100

agatattctt ttatgttatg ttcttgtgaa caaagcacaa agtttgagtg agtgccaacc     2160

tatgcagatg gtagaagtgg cattcctggc tttggcttgg aagaattgac gaccatcaga     2220

ccttgaagca gaacttcaca gcagcctgtc ctcatcagca acccaaccac cttcatcagc     2280

aacccaacca ccttcatcag caacccaacc acctcgtcag caacccaacc acctcgtcag     2340

caacccaacc acctcgtcag caacccagcc accttcatca gcaacccaac cacctcatca     2400

gcaacccagc caccttcatc agc                                             2423


<210> 2895
<211> 3468
<212> DNA
<213> Homo sapiens

<400> 2895
gcgagccgaa gcgcgggaag cagctcttgt ggatcctcag tggcggaggc tcggtcaccc       60

ggataggtaa aggaaaacat gcctgccaca cggaagccaa tgagatatgg gcatacagag      120

ggacacacgg aggtctgttt tgatgattct gggagtttta ttgtgacttg tggaagtgat      180

ggtgatgtga ggatttggga agacttggat gatgatgatc ctaagttcat taatgttgga      240

gaaaaggcat attcatgtgc tttgaagagt ggaaaactgg tcactgcagt ttctaataat      300

actattcaag tccacacatt tcctgaagga gttccagatg gtatattgac tcgcttcact      360

acaaatgcaa accatgtggt ctttaatggg gatggtacta aaattgctgc tggatctagt      420

gattttctag tcaaaattgt ggatgtgatg gatagcagcc aacagaaaac atttcgagga      480

catgatgccc ctgttttaag tctttccttt gatcctaagg acatctttct ggcatcagct      540

agttgtgatg gatctgtcag agtgtggcaa atttcagatc agacatgtgc tattagttgg      600

ccactgctac aaaaatgcaa cgatgtgata aatgcaaaat caatctgcag acttgcttgg      660

cagccaaaaa gtgggaagtt actggcaatt cctgtggaaa aatctgttaa gctatataga      720

agagaatctt ggagtcatca atttgatctt tcagataatt tcatctctca gaccctcaat      780

atagtaacct ggtctccctg tgggcaatat ttagctgcag gtagtattaa tggtctaatc      840

atagtttgga atgtggaaac caaagactgc atggaaaggg tgaaacatga gaaaggttat      900

gcaatttgtg gtctggcatg gcatcctact tgtggtcgaa tatcgtatac tgatgcggaa      960

ggaaatctag ggcttctaga gaatgtttgt gaccccagtg gaaagacatc aagcagtaag     1020

gtatctagca gagtggaaaa ggattataat gatctttttg atggagatga tatgagtaat     1080

gctggtgatt ttctaaatga caatgcagtt gagatccctt ctttttcaaa agggattata     1140

aatgatgatg aggatgatga agacctcatg atggcttcag gtcgtcctag acagcgaagt     1200

cacatcctag aagatgatga aaactcagtt gatatttcaa tgctaaaaac tggttctagt     1260

cttctcaaag aggaggagga agatggtcaa gaaggcagca ttcacaatct accacttgta     1320

acatcccaaa ggccatttta tgatggaccc atgccaactc cccggcaaaa gccatttcag     1380

tcaggttcta caccgttgca tctcactcac agattcatgg tgtggaactc tattggaatt     1440

attcgctgct ataatgatga gcaagacaat gccatagatg tggagttcca tgatacctcc     1500

atacaccatg caacacactt atcaaacact ttgaattata caatagcaga tctttcccac     1560

gaagctattt tgttggcatg tgaaagcact gatgaactag caagcaagct tcactgcctg     1620

cactttagtt cttgggattc aagcaaagag tggataatag acttgcctca gaatgaggat     1680

attgaagcca tatgtctcgg tcaaggatgg gctgctgccg ctactagtgc cctgcttctt     1740

cgattgttta ctattggagg ggttcaaaaa gaggtattca gccttgctgg acctgtggtg     1800

tcaatggcag gacatggaga acagcttttc attgtttatc acagaggtac aggatttgat     1860

ggggatcagt gccttggagt tcaactgcta gagctgggga aaaagaaaaa acaaattttg     1920

catggtgacc ctcttcctct tacaaggaaa tcctaccttg catggattgg gttttcagct     1980

gaaggtaccc cttgttacgt ggattcagaa ggaattgttc gaatgcttaa cagaggactt     2040

ggtaatacgt ggactcctat atgtaataca agagagcact gcaaaggaaa atctgatcac     2100

tactgggtgg ttggtatcca tgaaaatccc cagcaactaa ggtgcattcc ttgtaaaggt     2160

tctcggtttc ccccaaccct tccacgccct gctgttgcta tattatcctt taagcttcct     2220

tactgtcaga ttgcaacaga gaaaggacaa atggaggagc aattttggcg ttcagttata     2280

tttcacaacc accttgatta tttagctaaa aatggttatg aatatgaaga gagcactaaa     2340

aatcaagcaa caaaagagca acaggaactt ttaatgaaaa tgcttgcgct ttcttgtaaa     2400

ctggagcgag aattccgttg tgtggaactt gctgatctaa tgactcaaaa tgctgtgaat     2460

ttagccatta aatatgcttc tcgctctcgg aaattaatac tggctcaaaa actaagtgaa     2520

ctggctgtag agaaggcagc cgaattgaca gcaacccagg tggaagagga agaagaagaa     2580

gaagatttca gaaaaaagct gaatgctggt tacagcaata ctgctacaga gtggagccaa     2640

ccaaggttca gaaatcaagt tgaagaagat gctgaggaca gtggagaagc tgatgatgaa     2700

gaaaaaccag aaatacataa gcctggacag aactcgtttt ccaaaagtac aaattcctct     2760

gatgtttcag ctaagtcagg tgcagttacc tttagcagcc aaggacgagt aaatcccttt     2820

aaggtatcag ccagttccaa agaaccagcc atgtcaatga attcagcacg ttcaactaat     2880

attttagaca atatgggcaa atcatccaag aaatccactg cacttagtcg aactacaaat     2940

aatgaaaagt ctcccattat aaagcctctg attccaaagc cgaagcctaa gcaggcatct     3000

gcagcatcct atttccagaa aagaaattct caaactaata aaactgagga agtgaaagaa     3060

gaaaatctta aaaatgtatt atctgaaacc ccagctatat gtcctcctca aaacactgaa     3120

aaccaaaggc caaagaccgg gttccagatg tggttagaag aaaatagaag taatattttg     3180

tctgacaatc ctgacttttc agatgaagca gacataataa aagaaggaat gattcgattt     3240

agagtattgt caactgaaga aagaaaggtg tgggctaaca aagccaaagg agaaacggca     3300

agtgaaggaa ctgaagcaaa gaagcgaaaa cgtgtggttg atgaaagtga tgaaacagaa     3360

aaccaggaag aaaaagcaaa agagaacctg aatttgtcta aaaagcagaa acctttagat     3420

ttttctacaa atcagaaact atcagctttt gcatttaagc aggagtaa                  3468


<210> 2896
<211> 1544
<212> DNA
<213> Homo sapiens

<400> 2896
gatgtcacgt ccggcggcgg cggcagcggc agcggcagcg gcgctgagtt ttgtctcccg       60

ggccgtctgg gcgcgcgcgg gtgtcccaga atgaaatatg actgaggact ctcagagaaa      120

ctttcgttca gtatattatg agaaagtggg gtttcgtgga gttgaagaaa agaaatcatt      180

agaaattctc ctaaaagatg accgtctgga tactgagaaa ctttgtactt ttagtcagag      240

gttccctctc ccgtccatgt accgtgcatt ggtatggaag gtgcttctag gaatcttgcc      300

tccacaccac gagtcccatg ccaaggtgat gatgtatcgt aaggagcagt acttggatgt      360

ccttcatgcc ctgaaagtcg ttcgctttgt tagtgatgcc acacctcagg ctgaagtcta      420

tctccgcatg tatcagctgg agtctgggaa gttacctcga agtccctctt ttccactgga      480

gccagatgat gaagtgtttc ttgccatagc taaagccatg gaggaaatgg tggaagatag      540

tgtcgactgt tactggatca cccgacgctt tgtgaaccaa ttaaatacca agtaccggga      600

ttccttgccc cagttggaag gcataaatgt tggctgactg tcaaatgctt gtgggaggtc      660

cccacggagt ggagaagcgg gagactcagc ttaatcacag acaaagttgt gcatgagaga      720

cggagtctca ctctgttgcc caggctggag ttcaatggtg caatgatctc ggctcactgc      780

aacctccgcc tcttgggtgc aagtaactct cctgcctcag cctcccgagt agctgggatt      840

acaggtccct tcagagccgt gaaggcgggc atcctgtgac acagctgaca cagcatggag      900

ccttcatctc ctatgtgcgt ttcttaggtc actctgaggg gtggggccac aagctaccac      960

ctacagaatt gataccttta gttcaaagcc attgaccaac ccaggttcat gaattttcag     1020

gcagaaggta ccaagacaac cccattaggc aactaggaag acaggccagg aaaggcctac     1080

gatgtcgtca ttacagctgc caccgtcaga gggttcatta tgtgctcaga ggtgcacagg     1140

gcctcactgg ctgctggaca gaacaggggc tgctcccagg accaggcagg gtggggctgg     1200

aaaccaaccc aaggctctca aagctccagg gctgagccat ggcatctctg tgccctgttc     1260

cccaccaccc aacaccgagc agttcctcaa atggctgaaa gctcagaaaa tcagttttaa     1320

aacaaactat tggaggatgt tttcttatac cactagacat tttttttgtt taacaatcgc     1380

aatagattaa atttaaaaaa atatttagga gaacatagtt ccagaataca gggaaaaata     1440

agaacctatg ggaaaacaag ttgatttctg aaaagtttca aaactatgaa atgaccaacc     1500

tgttagaatt ggtcaagtag ttctttaatt tgcaactatg tggc                      1544


<210> 2897
<211> 3189
<212> DNA
<213> Homo sapiens

<400> 2897
atgatcagca agggtggcag tgaagctctt ctgcagaccc tggtagacac agcgaggaca       60

gctcctccag actatgacat cctcctgcct ctcttccggc tgctggccaa agttggccta      120

agagataaaa agattggacg gaaggcccta gaattggaag cacttgatgt gacattgatt      180

ctggccagga agaacctatc ccatggccag aatctcctcc actgtctctg ggctctgcgt      240

gtgtttgcct ccagtgtctc catgggagcc atgctgggaa ttaatggagc catggaactg      300

cttttcaagg ttattactcc ttacacccga aagcgcaccc aagcaatcag ggcagccact      360

gaagttttgg cagcattgct gaaatccaag tcgaacggcc gcagagcagt gaaccgaggc      420

tacgtcacca gcctgctcgg gctgcaccag gactggcaca gccatgacac agccaacgcc      480

tacgtgcaga tccgacgggg cttgctgctc tgcctcaggc acattgctgc cctccggtcc      540

ggcagggagg ccttcctggc agcacagggc atggagatcc tcttcagcac cacacagaac      600

tgcctggatg acaagagcat ggagcccgtc atctctgtgg tgcttcagat cctgaggcag      660

tgctacccta cgagtccact tcccttggtc acagccagca gtgcctatgc cttcccggtc      720

cccgggtgca tcaccactga acctccacat gatctacctg aagaggattt tgaagatgat      780

ggcgatgatg aagtggacaa agactctgat actgaagatg ggaaagtgga agatgatgac      840

ttggaaacag acgtgaacaa gctgagttcc aaacctggtc ttgaccgacc tgaagaggaa      900

ctgatgcaat atgaggtgat gtgtcttgag ctctcctata gctttgagga actgcagtcc      960

aaacttggag atgatttgaa ctctgaaaag actcagtatg ccaatcacca ccacattcca     1020

gccgctgcct cctcaaaaca gcattgctac agcaaggacc aaagctcctg tgggcaagaa     1080

agagaatatg ctgtccagac ttcccttctg tgcagggtga agacgggaag gtccactgtg     1140

catctaggct ccaaaaaaaa tcctggagtg aacctgtacc aaaatgtgca atccaatagt     1200

ctcaggagag attcttctga aagtgaaatc cctgacattc aggcttcccc gaaagcagat     1260

gcctgggacg tagatgcaat tttctgccca aggatgagtg cctccttttc taattccact     1320

aggactagag aagttgtcaa agtaatagat aagcttctgc agacacatct gaagcgtgtc     1380

cctttccacg atccctatct ttatatggcc aaagccagaa gaaccagctc tgtggtggac     1440

ttcaagatga tggcatttcc tgatgtctgg ggacactgtc cccctcccac cacccagcct     1500

atgttggaac gaaaatgtgg agtccaaagg atcaggatat ttgaggatat tcggaggctc     1560

atccagccaa gtgatgttat aaataaagtt gtcttcagtt tagatgagcc ttggcctttg     1620

caagacaatg cttccaattg tttacggttc ttctccaaat ttgagtcagg aaatcttcgc     1680

aaagccatcc aagtgcgtga gttcgagtat gacttgctgg tcaacgcaga tgtgaatagc     1740

acccagcacc agcagtggtt ctatttcaaa gtgagcggta tgcaggcggc catcccttac     1800

cacttcaaca tcatcaactg tgagaagccc aacagccagt ttaattatgg gatgcagccc     1860

accctatatt ctgtgaagga ggctcttctt ggcaaaccca cctggataag gacaggccat     1920

gaaatatgtt attacaaaaa tcattatcgc cagagtacag ctgttgcagg cggagcatct     1980

gggaagtgct actataccct cacctttgct gtcaccttcc cacacagtga ggatgtctgc     2040

tacctggcct accactatcc ctatacctac acagccctca tgactcatct tgacatcctg     2100

gaaaagagtg tcaacctcaa agaggtctac ttccggcaag atgttctctg ccagacgctg     2160

ggagggaatc cgtgtccctt ggtgaccatc acggccatgc ctgagtccaa cagtgatgag     2220

catctagagc agttccgaca tcgtccatat caggtgatca ctgctcgagt tcatccagga     2280

gagagcaatg ccagttgggt gatgaagggt accttggagt tcctggtcag cagtgaccct     2340

gtggctaggc tcttgaggga aaacttcatc ttcaagatca tacccatgct caacccagat     2400

ggtgtcatca acggcaacca cagatgctca ctgagcgggg aagatttgaa cagacaatgg     2460

ctttctccca gtgctcatct gcagccaacc atttaccatg ccaaaggcct cctctaccac     2520

ctgagcagca ttggccgaag tcccgtggtt ttctgtgact tccatggcca ctcccaaaag     2580

aagaatgtgt tcctttatgg ctgtagcatc aaggaaacct tgtggcaagc agcatgcact     2640

gtgggcacat ctactatcct agaggaggtc aactacagga ctcttcccaa aatccttgat     2700

aagctagcac cagcattcac aatgagcagc tgcagctttc tcgtggagaa atctcgagct     2760

tccacggccc gggtggtggt gtggagagag atgggggtgt ccagaagcta caccatggaa     2820

agcagctact gtggctgcaa ccagggccct tatcagtgta cacagaggct gttggagagg     2880

acaaagaatg aaagggctca cccagtggat ggccttcagg gtctacagtt tggtaccaga     2940

gaactggagg agatgggagc catgttctgt ttgggcctcc tcatcctgga gctcaaatct     3000

gccagctgca gccatcagct cctggctcaa gctgcaactc tgctgagtgc tgaggaggac     3060

gctctggacc agcacctcca acgattaaaa tcatccaatt tcctgccaaa gcatatttgg     3120

tttgcttacc acttttttgc cattacaaac tttttcaaga tgaaccttct tctgcatgtc     3180

tccccgtga                                                             3189


<210> 2898
<211> 1001
<212> DNA
<213> Homo sapiens

<400> 2898
gacttggacg tgcgagtcaa caaggtacag gacacatttc tctccgggga aatcttgtgt       60

gggcgccgag gcccggacgt agcaaccaaa cgtcgggaag aggcgccaaa aggatgctgg      120

gcctggctcc ttgaagcccg ggttttccct tttgagagcc acaaccaaga aataaaaatc      180

tagcaaagag ggggccactt tctgcggcga gatacgccct ctcggccgct cctccagctc      240

ccaggccccc tccctactcg acggatggct gcagctcctc caagttactg ttttgttgcc      300

ttccctccac gtgctaagga tggtctggtg gtatttggga aaaattcagc ccggcccaga      360

gatgaagtgc aagaggttgt gtatttctcg gctgctgatc acgaaccgga gagcaaggtt      420

gagtgcactt acatttcaat cgaccaagtt ccaaggacct atgccataat gataagcaga      480

cccgcctggc tctggggagc agaaatggga gccaatgaac atggagtgtg catagccaat      540

gaagccatca acaccagaga gccagctgcc gagatagaag ccttgctggg gatggatctg      600

gtcaggcttg gtttagaaag aggggaaaca gctaaagaag ccttagatgt cattgtctcc      660

ttgttggaag aacatggaca aggtgggaat tactttgaag atgcaaactc ctgccacagc      720

ttccaaagtg catatctgat tgtggatcgt gatgaagcct gggtgctcga gaccataggg      780

aagtactggg ctgccgagaa agtcacagag ggagtgaggt gcatttgcag tcagctttcg      840

ctcaccacta agatggatgc agagcatccg gaactcagga gttacgctca gagccaaggt      900

tggtggacgg gagagggcga gttcaatttt tccgaagtct tttctccagt tgaggatcat      960

ctagactgcg gtgctggcaa agacagctta gaaaaacaag a                         1001


<210> 2899
<211> 544
<212> DNA
<213> Homo sapiens

<400> 2899
aacaacaaaa gccaagccaa aagccaaaac aaacaaatcc agccaaatca atcattgaga       60

aacaataata ttaataaaat ccaaaactaa atcaaaccaa tcaaggcacc aagacgcagg      120

ggggatatcc acagttcgat caaggttgac gatgtgtcac actgtgtaag ggaatcgcat      180

ggagatgggc attccgaact gttaatgggg acatgggact ccagttgtct ctgatcactt      240

gtgtggattt tcctggcgta gaacgacaga agccgctagt aagtcgccaa gacctacagc      300

aggaattctg caccaaagct taaaaaagtg aggaggaagt aaatgctaaa ttattcatga      360

gcctcatttg acagcacatc agaaggggaa gtgtcagggg ttttataaag ggcataaaat      420

cttgttattt taatttgcat ctgggagaat gtctgagcaa ggagacctga atcaggcaat      480

agcagaggaa ggagggactg agcaggagac ggccactcca gagaacggca ttgttaaatc      540

agaa                                                                   544


<210> 2900
<211> 373
<212> DNA
<213> Homo sapiens

<400> 2900
ggtcctaggc tcacctaagc cagaagagat tccccttact tggatacaac caggaactac       60

tgttctcaac tgctcccatg acttcctgtc agaaagtttg attatcatta gaagaatggc      120

catcttttaa agtgattcat tgacttgtcc ctggagaaat catgagttag atgagagtgt      180

ttagtgggaa gtgaaaagac ccgtccacgg tttcggatga gatcctcgtt ggactgtgat      240

cccaggatat tacccaggcc cagatcgtag acaacctccc aatggagtcc tgcccctaca      300

cgggcagggg gtgaaataat gattcccttt cttaattttc tttagccatg aaatttatta      360

aaaatgtatg tct                                                         373


<210> 2901
<211> 589
<212> DNA
<213> Homo sapiens

<400> 2901
tgagaagcag tttggaccca gctgaaaaat tttatttatg gagacttgta atcagcctga       60

tatacagaga acactctgga ctggaaatat agtcagatcc tgtgttgcca taagcccttg      120

gcccacattt aagtgggaat gcagctagct tggatgtctg aaactttgta ggcgcctctg      180

tctgaatcct gaacacaggc accaggacta ctgagagctc gtcatctgtg caggatagcc      240

acacagcaaa catgtttgca aaactgaaga agaaaattgc agaagagact gctgttgctc      300

agaggccagg aggtgctact aggatcccac ggtctgtgag caaggaatca gttgcctcaa      360

tgggagctga ctcaggagat gactttgctt ccgatggaag cagctccaga gaagatcttt      420

catcccagct tctgagaagg aatgaacaga tacggaagtt agaggccaga ctttctgact      480

atgctgaaca ggtccgaaac ttgcagaaga taaaagagaa gcttgaaatt gcattagaaa      540

aacaccagga ttcttccatg cggaaatttc aagagcagaa tgagacatt                  589


<210> 2902
<211> 2018
<212> DNA
<213> Homo sapiens

<400> 2902
aaaactccag cccgaaggga tctggaagca gtttttaaga ctgtgtgtgt atgagacagg       60

tcgcgtccta gagcaaacgg ttttttttgt aaacagacgg catcctaaca ggggcggtgc      120

tacccagtct gcggggagtc gctcgggatc gaagcacctc agagctcctt cgagcgtatc      180

ccttcgggaa agccccacgc cttccccgag gcgcctcctc cggcctgcag cacgccctcg      240

tcctgcactt cctcctcgga atctgcaaga cagagtctag ctctttcacc caggctggag      300

tgaagtggtg caatctcagc tcagtgcaac ctccgccccc tgggttcaag tgattctcct      360

gcctcagcct ccccagtagc tgggattaca gtgatatcct gagagaagat gggaaagggc      420

tgcaaggttg tggtttgtgg attgttatct gtggggaaaa ctgcaatttt ggagcagctc      480

ctttatggaa atcatactat tggaatggaa gattgcgaaa caatggaaga tgtatacatg      540

gcttcagtag aaacagaccg aggagtaaaa gaacagttac atctttatga caccagaggt      600

ctacaggaag gcgtggagct gccaaagcat tatttttcat ttgctgatgg cttcgttctt      660

gtgtacagtg tgaataacct tgaatccttt caaagagtgg agcttctgaa gaaagaaatc      720

gataagttca aagacaaaaa agaggtagca attgtggtat taggaaacaa aatcgacctt      780

tctgagcaga gacaagtgga cgctgaagtg gcacagcagt gggcaaaaag tgagaaagta      840

agactgtggg aggtgactgt tacagatcgg aaaactctga ttgaaccatt cactttatta      900

gccagtaaac tttctcaacc ccagagcaaa tcaagctttc ctttgcctgg gaggaaaaac      960

aaagggaact ctaattctga gaactaaaaa tcagtaattt ccacaattgt atgttgaata     1020

gtgattgcct ttaagtgtct gtgaacatgg agtaatatta ctatttaaaa taggccattt     1080

gtatctacct ttggtcctta ggaaaattcc taaggaagtc aattaatgca ctttagatgt     1140

taaaagtatt tgggctaagg ttattattgc ctgatatgaa ataatatatt cttattctca     1200

ttgtttgaaa cctgtctttg aaattagcac ctttgttatt tatgttgtac ttgtgaaaac     1260

agtaaaatag tttggatagt tatgcaaatg cacctatgtg taacttcccc ccaaccccaa     1320

gctgtttcgg aagatatcat aatcattctg tgtaacatta tgcaaacttc taagcccaaa     1380

catgactttg tttttaaaaa gttcattaat ctaatgtcta ggattataaa acattttttt     1440

gtgtctaaat tggacccaaa acattgaaca gtttggggta gtaagctaaa tttcatcttg     1500

tggagatttt gctaaacaga ctaagaccca tgatttagct ttgctcaaat tagaatgttt     1560

agcatgagtt gaggtaccag gtagtgttaa gtaggttcat cacgctctaa ggccgttttt     1620

tccttagcca gacccctgtt gatagaccag atacttgagg gcaaactgtt tgctcctcct     1680

cttgaaaatg attaggcact taaggacagt aaagctgtat tttctggaag gaagactgta     1740

tcttctggaa tagttttcta gaaaactagt catatacaat aaaagtatca aaaatattgg     1800

gctctaattt gatctgactt agatgtctga gtttgtgttg tttctctaaa gattttggca     1860

agactcaagc aatgtggctg actgtaactt tattaattta aaaggtagga agtaagctac     1920

ttagtggttt cacctgtgaa ataactattt tgactgaaat gtaaaataag ctattcaaca     1980

aagaacatat taaaacatca agtaatttgt aacatctt                             2018


<210> 2903
<211> 2818
<212> DNA
<213> Homo sapiens

<400> 2903
gctcgggaaa ggggttcgga accggtctag gctcaagtta aatctccctc taaagagcca       60

acactggttt ctttggcgac tcggtttcta ctctaaacag gtcccgctcc acagtctggg      120

cgggcctgtg tgtgcgttga gtagcctcta gcgtgaaaac ttcatggtta aaagggaagt      180

accggaggca agaaatagct ttcgaggcac tggtttgtta gagtagtggt acgtagtgcg      240

ccgccctgaa cgggggctga gacgctgctt ttccagaagt gccagtgagg acgtggcaag      300

accgcctcgg acgtacgctt cctctacctc agcccgtcgg gttaggggcg cgggaggcgc      360

agaggctgct gggaacgcgc atgcgctcag cgcggcgggg agtccacctt taacgtccgc      420

gggcgcgggg tgtgtcgggt gtcgacggcg gcgctttgcg gccggtcgtg cgggtcgggc      480

gcgggcgggc gcggcggcag tggcgcgcac aggtgattga ctggccagct gcctgaagga      540

gcgccaggtc ctccttgctg gcaggtggcg aagcccattg gggcggcggt gcagaccgcg      600

gcggcggctg cggcggtctg gctcgggagg cgttcctggg gccaaggcca tggccccgcg      660

gctgcagctg gagaaggcgg cctggcgctg ggcggagacg gtgcggcccg aggaggtgtc      720

gcaggagcac atcgagaccg cttaccgcat ctggctggag ccctgcattc gcggcgtgtg      780

cagacgaaac tgcaaaggaa atccgaattg cttggttggt attggtgagc atatttggtt      840

aggagaaata gatgaaaata gttttcataa catcgatgat cccaactgtg agaggagaaa      900

aaagaactca tttgtgggcc tgactaacct tggagccact tgttatgtca acacatttct      960

tcaagtgtgg tttctcaact tggagcttcg gcaggcactc tacttatgtc caagcacttg     1020

tagtgactac atgctgggag acggcatcca agaagaaaaa gattatgagc ctcaaacaat     1080

ttgtgagcat ctccagtact tgtttgcctt gttgcaaaac agtaataggc gatacattga     1140

tccatcagga tttgttaaag ccttgggcct ggacactgga caacagcagg atgctcaaga     1200

attttcaaag ctctttatgt ctctattgga agatactttg tctaaacaaa agaatccaga     1260

tgtgcgcaat attgttcaac agcagttctg tggagaatat gcctatgtaa ctgtttgcaa     1320

ccagtgtggc agagagtcta agcttttgtc aaaattttat gagctggagt taaatatcca     1380

aggccacaaa cagttaacag attgtatctc ggaatttttg aaggaagaaa aattagaagg     1440

agacaatcgc tatttttgcg agaactgtca aagcaaacag aatgcaacaa gaaagattcg     1500

acttcttagc cttccttgca ctctgaactt gcagctaatg cgttttgtct ttgacaggca     1560

aactggacat aagaaaaagc tgaataccta cattggcttc tcagaaattt tggatatgga     1620

gccttatgtg gaacataaag gtgggtccta cgtgtatgaa ctcagcgcag tcctcataca     1680

cagaggagtg agtgcttatt ctggccacta catcgcccac gtgaaagatc cacagtctgg     1740

tgaatggtat aagtttaatg atgaagacat agaaaagatg gaggggaaga aattacaact     1800

agggattgag gaagatctag cagaaccttc taagtctcag acacgtaaac ccaagtgtgg     1860

caaaggaact cattgctctc gaaatgcata tatgttggtt tatagactgc aaactcaaga     1920

aaagcccaac actactgttc aagttccagc ctttcttcaa gagctggtag atcgggataa     1980

ttccaaattt gaggagtggt gtattgaaat ggctgagatg cgtaagcaaa gtgtggataa     2040

aggaaaagca aaacacgaag aggttaagga gctgtaccaa aggttacctg ctggagctgg     2100

tctgtaagat attctgggac agcactgttg ccattaagtg ccttgttttt ttatgttcac     2160

aaatgtatat gaagaaactt tctcaaactt actctttcta ataacccact aaagccagct     2220

taaacactct aaaagtactt tgtaaaccaa caataacttg atgtgtagca ttccatatta     2280

tttcattacg ttgtactcct aaaaatggga agctgttaat aaattataac atttaggtca     2340

gcactctgca tccatgagta ttgtagatat ttatattttg tgagatatta acttgtttaa     2400

gaaaaatccg attggattac tatggaaaaa gcaacttgcc tgttctgttt ctttgcatac     2460

tttgtgacct aacagtttta acagacattc tattatatga atacagtttt tttgatacta     2520

ttagattaac ttgaagttta ataccaaata ttatgctaag agtagaaaag ctttctgctg     2580

acccctgatt tcttagaaat atcccacata atccagctta tcccttttct gtatatgttt     2640

attcaggttt acctgatgtc tcaaaatgaa accaaattaa gcctttttaa aggctgatgt     2700

gccatttgta ttaagttatc tttgtcattt taaagacatg aattccccaa gcctaattcc     2760

tacttaagga agagagacaa tttagtcctt actttagaaa ataaatactt aagcataa       2818


<210> 2904
<211> 3212
<212> DNA
<213> Homo sapiens

<400> 2904
acgctgggag ctgcggacgg cgggcgcggg ctgggccggg tctagtggcg gccgcacacc       60

tcgcgtcgtc tggggcagtg ttgcgcgtgc gctgatgaca ggcccgacac gcccctctta      120

cgtccgcgaa cccgtcttcg ctcagcctct cgcagctttg cgctcgtggg agagtcccgc      180

ctccttctgc gaaccgcacc acccagatcc cggggtgcgc ggagggcgcg tctctgacgg      240

aagccggggc ggacggtcgg agtccggaag aaaaacagtc cgcgacagct aggcgcgtga      300

gaccggccgc ccgcagggct gctctggccg ggacccgctg gccgggagac gcgaacctgc      360

cggaccaccg cgcggggacg acggcggcca tgagctcgcg gaagctgagc gggccgaaag      420

gcaggaggct cagcacatac atcaggaggt ctgcctgatc ccatggtgaa ccccgggaat      480

ccgaaatcag attgagataa gatcctttag ggaagtgact tagcctggtc tcttgcctgc      540

tctttcacgg ggaacaacgc taatcgccca cttagtctaa gtcacgatgc ttggatttgc      600

tgctaatcgt cggatttgag agtgggaaca agaaatccgg acttttgctc tccatcctct      660

tagacataca cgtcgtgact tggaacgtgg cttcggcagc gccccctcta gatctcagtg      720

acctgcttca gctgaacaac cggaacctca atcttgacat atatgttatt ggtttgcagg      780

aattgaactc tgggatcata agcctccttt ccgatgctgc ctttaatgac tcgtggagca      840

gtttcctcat ggatgtgctt tcccctctga gcttcatcaa ggtctcccat gtccgtatgc      900

aggggatcct cttactggtc tttgccaagt atcagcattt gccctatatc cagattctgt      960

ctactaaatc cacccccact ggcctgtttg ggtactgggg gaacaaaggt ggagtcaaca     1020

tctgcctgaa gctttatggc tactatgtca gcatcatcaa ctgccacctg cctccccaca     1080

tttccaacaa ttaccagcgg ctggagcact ttgaccggat cctggagatg cagaattgtg     1140

aggggcgaga catcccaaac atcctggacc acgacctcat tatctggttt ggagacatga     1200

actttcggat cgaggacttt gggttgcact ttgttcggga atccattaaa aatcggtgct     1260

acggtggcct gtgggagaag gaccagctca gcattgccaa gaaacatgac ccgctgctcc     1320

gggagttcca ggagggccgc ctactcttcc cgcccaccta caagtttgat aggaactcca     1380

acgactatga caccagtgag aaaaaacgca agcctgcatg gaccgatcgc atcctgtgga     1440

ggctgaagcg gcagccctgt gctggccccg acactcccat accgccggcg tcacacttct     1500

ccttgtctct gaggggctac agcagccaca tgacgtacgg catcagcgac cacaagcctg     1560

tctccggcac gttcgacttg gagctgaagc cattggtgtc tgctccgctg atcgtcctga     1620

tgcccgagga cctgtggacc gtggaaaatg acatgatggt cagctactct tcaacctcgg     1680

acttccccag cagcccgtgg gactggattg gactgtacaa ggtggggctg cgggacgtta     1740

atgactacgt gtcctatgcc tgggtcgggg acagcaaggt ctcctgcagc gacaacctga     1800

accaggttta catcgacatc agcaatatcc ctaccactga agatgagttt ctcctctgtt     1860

actacagcaa cagtctgcgt tctgtggtgg ggataagcag acccttccag atcccgcctg     1920

gctccttgag ggaggaccca ctgggtgaag cacagccaca gatctgagcc aggatgggag     1980

tgaatcccag gcggaggcca gagctggcag ccagctctgc ctttccactg ccgggagtgc     2040

tgggggccca gcctggcccc ctgaagagac agccaagtgt cgtccacata ctcctcccag     2100

agtgagctct aaccaggctc atttgctctc tccactactc atctctggaa ttagccgctt     2160

aaatacaggt ttttgttgct gagatgtgag tgaaaccagc tagtgtgtca acagtgaaga     2220

cctggggaca gttctgcgtc tcatttctgg attcctaccc cctcttctag tcttgcccaa     2280

gtagtcctgc caggcacatg ccccatttgg cacaggcctg cattcttgtc gtgccgtcct     2340

gggcctcagg ctgtctggga ggggagatgc tcacatttgt acaggctaca tagactggtg     2400

caagcagtgc tggattccag gagtcttggc atctcatagc ttgtccccgt gaggagtgag     2460

cagagggtct gggatttctg ctttcagcaa aagcagtctg actcagtggg cagaatggag     2520

gggcccctct agccaggctc ttacgccatg gttatgagca ggttgatgag ggtccttcgg     2580

ccagcacaac cttcctccct actcacggca tggagtctga ctgcatggaa gttccagatc     2640

ctgacagaga gaactgggaa ggatccaggt tcgcttccgt tggtagcttg agtcccatgc     2700

ctccaccctg ccatctgagg aaggggtgac aagtggtcaa ggagctgtgg ccacagactt     2760

ttccagggtg gtccttggca ggtgaggtgc gtctgtgcca cccttgtcag gagccattga     2820

cgacgggccc cccctggacc ccccgggacc tcagagtggg ggcaggcaga agggagaacc     2880

agctcaagac attttggagg atctggccct ggggttcttc agagaacacc ctctaggggc     2940

tttggggaca tggcctgtcc ccacatccag cacttgcctc cgccatggtc actcggcagc     3000

ccttttccca ggagaagaca cctctgggag cctgctcagt gcttgtcctg ccatcctgtg     3060

tcctgggact gagggttact ccagttgctc tgtgttgcat actctccccc gcaagcctgt     3120

gtatgaagaa ttgtcccctg gcttccagca ggccatggct ggctgttttg tgactgttac     3180

attgtgcagg ggtaattatt agcgtggctt tt                                   3212


<210> 2905
<211> 1874
<212> DNA
<213> Homo sapiens

<400> 2905
atcgttggtc cgggcgccgc gagggcgggg cccgcagttc ggttgcgctg cggagcgcag       60

ctgtgaggga gtcgccagtg caggcctgag tgttccttcc agcatgtcgg agggggagtc      120

ccagacatca gtgtcacctc ctgtgacctc cacaacctca gctgcttccc cagaggaaga      180

agaagaaagt gaagatgagt ctgagatttt ggaagagtcg ccctgtgggc gctggcagaa      240

gaggcgagaa gaggtgaatc aacggaatgt accaggtatt gacagtgcat acctggccat      300

ggatacagag gaaggtgtag aggttgtgtg gaatgaggta cagttctctg aacgcaagaa      360

ctacaagctg caggaggaaa aggttcgtgc tgtgtttgat aatctgattc aattggagca      420

tcttaacatt gttaagtttc acaaatattg ggctgacatt aaagagaaca aggccagggt      480

catttttatc acagaataca tgtcatctgg gagtctgaag caatttctga agaagaccaa      540

aaagaaccac aagacgatga atgaaaaggc atggaagcgt tggtgcacac aaatcctctc      600

tgccctaagc tacctgcact cctgtgaccc ccccatcatc catgggaacc tgacctgtga      660

caccatcttc atccagcaca acggactcat caagattggc tctgtggctc ctgacactat      720

caacaatcat gtgaagactt gtcgagaaga gcagaagaat ctacacttct ttgcaccaga      780

gtatggagaa gtcactaatg tgacaacagc agtggacatc tactcctttg gcatgtgtgc      840

actggagatg gcagtgctgg agattcaggg caatggagag tcctcatatg tgccacagga      900

agccatcagc agtgccatcc agcttctaga agacccatta cagagggagt tcattcaaaa      960

gtgcctgcag tctgagcctg ctcgcagacc aacagccaga gaacttctgt tccacccagc     1020

attgtttgaa gtgccctcgc tcaaactcct tgcggcccac tgcattgtgg gacaccaaca     1080

catgatccca gagaacgctc tagaggagat caccaaaaac atggatacta gtgccgtact     1140

ggctgaaatc cctgcaggac caggaagaga accagttcag actttgtact ctcagtcacc     1200

agctctggaa ttagataaat tccttgaaga tgtcaggaat gggatctatc ctctgacagc     1260

ctttgggctg cctcggcccc agcagccaca gcaggaggag gtgacatcac ctgtcgtgcc     1320

cccctctgtc aagactccga cacctgaacc agctgaggtg gagactcgca aggtggtgct     1380

gatgcagtgc aacattgagt cggtggagga gggagtcaaa caccacctga cacttctgct     1440

gaagttggag gacaaactga accggcacct gagctgtgac ctgatgccaa atgagaatat     1500

ccccgagttg gcggctgagc tggtgcagct gggcttcatt agtgaggctg accagagccg     1560

gttgacttct ctgctagaag agaccttgaa caagttcaat tttgccagga acagtaccct     1620

caactcagcc gctgtcaccg tctcctctta gagctcactc gggccaggcc ctgatctgcg     1680

ctgtggctgt ccctggacgt gctgcagccc tcctgtccct tccccccagt cagtattacc     1740

ctgtgaagcc ccttccctcc tttattattc aggagggctg ggggggctcc ctggttctga     1800

gcatcatcct ttcccctccc ctctcttcct cccctctgca ctttgtttac ttgttttgca     1860

cagacgtggg cctg                                                       1874


<210> 2906
<211> 756
<212> DNA
<213> Homo sapiens

<400> 2906
gacctttctg cccctggagt ccccacgcag gctggagccc gagccccgag ggcctgcgag       60

ctccgcggct cccacaggag aggttcaaga ccctgcttac catgactacg cgtggaggcg      120

gaaggaggcg acacggcctc cagggctggg ttagatcgtg atagacgtcg ctccctgagc      180

gcgtcctggg ggcattaggg agtcctggca gcgggccgga ccgtgtcccc gccagagctc      240

tgggctctgg ggatgacgga gaggccgagg aggtgtgaag aagaatgttg gagttcctga      300

cagctggatt ctagaagtag aactatgagc tcacctttgg cctcccttag caagacccga      360

aaagtgcccc tgccctcgga gcctatgaat cctgggaggc gaggaatccg catctatgga      420

gatgaagatg aggtggacat gttgagtgat gggtgtggct cagaagaaaa gatctcagtc      480

ccttcctgct atggcggcat aggtgcccct gtgagtcggc aagtccctgc atcccatgac      540

tcggagctga tggccttcat gacgaggaag ttgtgggacc tggagcagca ggtgaaggcc      600

cagactgatg agatactgtc caaggatcag aagatagcgg ccctagagga cctggtgcag      660

accctccggc cacacccagc cgaggcaacc ctgcagcggc aggaggaact ggagacgatg      720

tgtgtgcagc tgcagcggca ggtcagggag atggag                                756


<210> 2907
<211> 2107
<212> DNA
<213> Homo sapiens

<400> 2907
gcgtggtggg cagtgtgggc atcccagcac tgagttctgc ccgggagaag ccgacccctc       60

ccgcaatgcc cgccccgccg tgcgcctcct gccatgctgc acgcgccgcc ctccgccgtc      120

cgctctcggg ccaagcgctg tgcggtgcct gcttctgcgc cgccttcgag gccgaggtgc      180

tgcacacggt gctcgccggc cgcctgctgc cgcccggcgc ggtggtggcc gtgggcgcct      240

cgggcggcaa ggactccacg gtgctggcgc acgtgctgcg cgcgctggcg ccgcgcctgg      300

gcatctcact gcagctcgtg gccgtcgatg agggcatcgg tggctaccgg gacgcggcgt      360

tggcggccgt gcggcgccag gcggcgcgct gggagctgcc gctcacggtc gtggcctacg      420

aagacctctt tgggggctgg acgatggacg ccgtggcccg cagcacagcc ggctccggcc      480

gcagccgctc ctgctgcacc ttctgtggag tgctgcggcg ccgggcgctg gaggaagggg      540

cgcgccgcgt gggagccacg cacatcgtga caggtcacaa cgccgacgac atggcggaga      600

ccgtgctcat gaacttccta cggggcgacg cggggcggct ggcccggggc gggggcctgg      660

gctctcccgg cgaggggggc gccctgccgc gctgccgccc gctgcagttc gcctcgcaga      720

aggaggtggt gctgtacgcg cacttccgcc gcctcgacta cttctccgag gagtgcgtct      780

acgcgcccga ggccttccgc ggccacgccc gggacctgct caagcgcctg gaggcggcgc      840

ggccgtccgc ggtgctggac ctcgtgcact cggccgagcg cctggcgctg gccccggccg      900

cgcggccccc gcgccccggc gcctgctccc gctgtggggc gctggccagc cgcgcgctct      960

gccaggcctg cgcgctcctg gacggcctga accgcggccg gccccgcctg gccatcggca     1020

agggccgccg gggtctggac gaggaggcga cgccggggac gcccggggat ccggcccggc     1080

cccccgcctc caaggccgtc cccaccttct agcgacttcg ggcctcccgc cgggatctga     1140

tgccgcgggg tgggggctgc ctgtaaatga cactgtgaat aaacccgtta ccttacctgg     1200

ccttccatgt ggggttggga aggagacggg ggcccattca cctgaaaccc tgaagaagct     1260

gggaccccag acttcgaggt ctcagggaag aagggtctcg aactgggctt caggctctga     1320

gggaggaggg ggctggggga ccatcctagg tctgagagag gagagggcca ggactaagcc     1380

tagaagaagt gggactgggg accccaggca tctgtggctg aggaaggagg gcctggggtc     1440

gtggactcct gggtctcagg gaggaggggg ctgaacaccg tgtgattctt gagcgagtgg     1500

ggattggttg gggacctcct gcccagggcc tctgctggtt ctgggtgcgc tcagcatggt     1560

cctgaccctc cttgagcatc agattcctga tgtttcctgt ttgcccgcag tggggtaagc     1620

ggagcgtgac ttgatggaca cacgccattc acagccgccg tcacgatgcc tcccttccag     1680

cgcttcgtgt gtagcacgca ctgcaccctc atttcgtctc caccacggtc tcactggctg     1740

tagcctgaag tggtaaatgg ccctaagaca cccagtcgga aggggtcaca ccgagggctc     1800

cctccaaagc tctcgaatat cacaggtcgt ggaattggtc ctcccccacc catcccctct     1860

cgaatctctc ctggtatctc tgtcacgggt gaggaggggt tggatgcgtt ccccaaacct     1920

tggactctgg aggcagggtt gtgtgagcct gtcggtgact tagcctcttt catgtcccat     1980

ttctcctatg aaaatataat cagccccctt cccccccgcc cccccatccc ccccgcatca     2040

aggcaccact gggaggaaat ggaagatcag agaagttgag gtgctcaata aatggtgacc     2100

acttgga                                                               2107


<210> 2908
<211> 564
<212> DNA
<213> Homo sapiens

<400> 2908
gaaatgtgta tgtcatgtgt ccaaattgta agatacttgc tgtaagtagc aaaaagatgg       60

gaaggaaagt ctacagacca aatcatatct gaatctcccc attctccctc tccacaaata      120

ttggtttagg aattctccga agtttgaagg ttatgaatgg ttatcactca aggattcaga      180

actaagcaga ggaaagaaat tcctaaggga acactgctca gaaagtactg cagcatgtct      240

tcaaatgcct gaggatcaag ttggaaaact agaagcaaca gaaaacacaa taagcgcaat      300

ggcggcggcc gcggcggagc agcaacagtt ctacctgctc ctgggaaacc tgctcagccc      360

cgacaatgtg gtccggaaac aggcagagga aacctatgag aatatcccag gccagtcaaa      420

gatcacattc ctcttacaag ccatcagaaa tacaacagct gctgaagagg ctagacaaat      480

ggccgccgtt ctcctaagac gtctcttgtc ctctgcattt gatgaagtct atccagcact      540

tccctctgat gttcagactg ccat                                             564


<210> 2909
<211> 559
<212> DNA
<213> Homo sapiens

<400> 2909
aaagtgaggt catgaataca acagcatctc gtgttcgcta cgtttcctct ggaattagcc       60

cacaagcaga ccccttgctc tcctagtggc aattaaccat gaccatcttc ctggagaaga      120

gaaactacct ggcaaagggc caaagtctta ggactgctgg gcaggagaac tggcctgtgt      180

tcaagttgag tcccagtttc tgccgcttta tctttcccgc ctcccggcag gcaggccgtt      240

aaccgtcttc cggaagacgc tgctagaacc ctccggccgc tcctgcccgc catcgtcccc      300

gaacgacact cgctcagctc tcagggccag agcggggcag gaggatgctt tcccagcccc      360

accatggagc tgcgctgtgg gggattgctg ttcagttctc gctttgattc agggaatcta      420

gcccacgtgg agaaggtgga atctttgtcc agtgatgggg aaggggtagg aggtggggcg      480

tcagccctga ccagtggcat tgcctcttcc cctgactatg aattcaacgt gtggacccga      540

ccagactgtg ctgaaacgg                                                   559


<210> 2910
<211> 2338
<212> DNA
<213> Homo sapiens

<400> 2910
atccttccgc agctgcacga cgcctgtgtg tctggccttt ccttcttctt ctcttccccg       60

gcagcacagt gtggctgttt gtctccttgc ccgccaaagt tctgcccagt ccaacgactc      120

cacgcagctc gcccttggtt atttggacaa gaggcacatt gacccaattt ggagacgtat      180

tttggaagga ggcgaacagt tgtctccaaa cgtggtgttg ccgtcagtgg tcccaccaag      240

aggaggggaa tggcagattc actggagtca acccccttgc cttcccccga agatcgtctg      300

gccaaactcc atccttctaa ggagctcctg gaatattatc aaaagaagat ggctgagtgt      360

gaggcagaaa atgaggactt gctgaagaaa ctggaactct acaaagaagc ttgtgaagga      420

cagcataaac ttgaatgtga tttgcagcag agggaggaag agattgctga attgcagaaa      480

gctctaagtg atatgcaggt ctgcctcttc caggaacggg aacatgtttt acgcctctac      540

tcagaaaatg accgactgag aatcagggag ctagaagaca agaaaaagat tcagaatctc      600

ttggctcttg tgggaacaga tgctggagaa gtgacctatt tttgtaagga gcctcctcac      660

aaagtcacca ttctccaaaa gactatccag gctgtaggtg aatgtgagca gagtgaatct      720

tcagctttca aagcagatcc taaaataagc aaaagaagac catcgagaga gagaaaagaa      780

agttctgagc attaccaaag agacatacag acactcatcc tacaggtgga agcactgcag      840

gctcagctgg gagagcagac caaactttct cgagaacaaa ttgaagggct catcgaggac      900

agacggattc accttgagga aatacaagtt cagcaccaga gaaatcagaa caaaatcaaa      960

gagctaacca aaaatcttca ccacacccaa gaactgctct atgagagcac caaagatttt     1020

ctgcaactca gatctgaaaa ccaaaataaa gagaagtcat ggatgcttga aaaagataat     1080

ttgatgtcaa agattaagca atatagggtg cagtgtaaga agaaagaaga taaaattgga     1140

aaagtgttgc ccgttatgca tgagagtcac catgctcaaa gtgaatatat taagtcccta     1200

aaagataagt tagtacaaga gaaaaagctg tccaatatgt accaagagca gtgcatttcc     1260

ttagaagaag aacttgcccg aattcgtgag gaagagggaa tgaggagaga gatcttcaag     1320

gatcgcacta acaagatggg gaagcgttta cagataatga caaaacgcta tgaggcattg     1380

gagcgtcgac gtatcctgga agtagaaggc tttaagacag atattaaagt tctccgacag     1440

aaactgaaag acttggagca aatgttgtat aaggcaacag ttaatgcccg ggcaaaccag     1500

gatcttgccc ttctgtgtga ggtccgtgac agcaatagac gggcacataa gatacaagga     1560

gaactgaaga atcttaagtc gaaagtgttt ggtctggaga atgaacttag actctgttaa     1620

tgtctacttt tggaaatggc ccccatttag aagaggtgtg cttcttgaaa cctgaggaca     1680

aggtcatctg ctgccagaaa atgtaaacct gagttgacta gagtggtggt attcattatt     1740

gtaaagacag cttgaagaat cggggaccac taggaaagct tttcttgcat actcagcttg     1800

ctttatcatt tttgctgtcc ttttaacact tgcgaggagt aggggcctgg tcctgaatga     1860

cttggaggct ttcattattt atcctgtctg tattgaccgg tttttgtttt ttcagaaggc     1920

agtgatgatg aaaacttagg aagaaggtat tttgcaataa gcttggctga gtgtccatgg     1980

gaagaatact ttccctaaag agagagaagc actcacagag gctgcctttc tcctgagctc     2040

ggggagaagg cagcacatca caacctgtca cattgaaata ggcgctcatt ctgctatttc     2100

accttccgtc ctgagcagag cctgaattac gtttttgggc aatttcatgg tgtttcacca     2160

gagggcgcta gagactcaaa cgaaatgtcc atctggaaag attcgggaga cactttgccg     2220

aggggatgaa gctgagatga tgcttgtatg gaaagtttga tatttttatc agtcacatgg     2280

cttttgaaaa atgatgtata tattttaaat taactatttt caataaaata tttcactc       2338


<210> 2911
<211> 5142
<212> DNA
<213> Homo sapiens

<400> 2911
acactgggct ccggcggcca gagtggggga ctaggtgaag cggcgccggg ccggggctgg       60

ccgggaccag gcccgaggct gagcggcggc gacagcggtg gccgggaggg gggaggagag      120

gcgcagccag aggagccgcc gcagtagctc ccccgcctcc cgggctgagg gcattttaag      180

aaagaaagat ggatcaacct agtggaagaa gtttcatgca agtattatgt gaaaaatata      240

gtcctgaaaa ttttccttat cgccgtggcc cggggatggg agtccatgtc ccagccacac      300

ctcagggctc tcctatgaaa gatcgcctca acctcccaag tgtactagtg ttgaacagct      360

gtggaataac ctgtgcagga gatgaaaaag aaattgctgc tttctgcgct catgtgtcgg      420

aactagatct ttctgacaac aaactcgaag actggcatga ggtcagtaaa attgtgtcaa      480

atgttcctca gttggagttt ctaaacctga gttccaaccc tctgaatttg tcggttttag      540

aaagaacatg tgctgggtcc ttctctgggg ttcgcaaact tgtcctcaac aacagcaaag      600

cttcttggga gacggtccac atgatactac aggagttacc agatttggag gagctcttcc      660

tgtgccttaa tgactatgaa acagtgtctt gtccttctat ttgctgtcat tctcttaagc      720

tactacatat aacagacaat aacctccaag actggactga aatacgaaag ttaggagtta      780

tgtttccttc actggatacc ctcgtcctgg ccaacaatca tttgaatgct attgaggagc      840

ctgatgattc attggccagg ttgtttccta atcttcgatc catcagcctc cacaagtcag      900

gtttgcagtc ctgggaagac attgataaac taaattcatt tcccaaactg gaagaagtga      960

gattgttagg aattcctctt ctgcagccat ataccaccga ggagcgaagg aaattggtaa     1020

tagccagatt gccatcagtt tccaaactta atggcagcgt tgttactgat ggtgaacgag     1080

aagattctga gagatttttt attcgttact atgtggatgt tccacaggaa gaagtgccat     1140

tcaggtatca tgaactgatc actaaatatg ggaagttgga gcctttggca gaagtggacc     1200

taagacccca gagcagtgca aaagtagaag tccactttaa cgatcaggtg gaagaaatga     1260

gcattcgtct ggaccaaaca gtggcagaac taaagaaaca gttaaaaact ctagtacaat     1320

tacccacaag caacatgctt ctctactatt ttgaccatga agcacccttt ggcccagagg     1380

aaatgaagta cagctctcgg gcattgcatt cctttggcat tagggatgga gataaaattt     1440

acgtggaatc caaaacaaaa taacctctac cagccttgtg aaaaacatac acataaggac     1500

ttgttgcagg gcatttgttt ttaatgtggt tttctttagg agggagaggt tgtttttgtt     1560

ttgttttgtt ctgtttaggt ttgggaagga ttttgtatat ttttccccct ggagtgagta     1620

ggggccattt ttgggtgttt tctaccacag attgatttgg ctcagccagc ggaattggcc     1680

acatttccag tgtatgtgcc ctctctaagg aaagatgaca aagaaatcac cgacttctta     1740

ctgtgttcac tgggatttgc ctgccacttg gttatcatta ctgttgggtg aacctgtgaa     1800

gataacatga acactgtagc cccttagaag ggtctcatag agaatttaaa cagggtgaca     1860

aggaatcttc acaggaaggg ccagaacttc tctctcccag ttcttccttc cgctaccctc     1920

cctccttggc ttttttggtt cagttccatt tttttttcat tttgacatgt ggtttaccta     1980

atagttttgt tctgttcata attcttattt ctcaacctgg gtgatttttt tgttctcatt     2040

tctccctttt gaaataattg aaagtgtttt aagcattttt aacctgattc taatctcagg     2100

tacgcagtaa gaagctataa ctctgttaga acctcgaaga gtagatgtag aatgaaaact     2160

ccaggaaaac ttgcagttat tctggaagca ccggcagaac agtctgatct ctttgtatgt     2220

tactaactca cttttaatgt ccctgtacat tatgtcagcc attactttca taacatgaaa     2280

tatgtcagat tccagagttc ttttattttt gcttattgaa tgtatttcct catatctttc     2340

tttttcatta ctttaaacta ttgggaattg aggcctgact tcataaataa ttcaatagag     2400

tcctggatac gtgcaccagg agagttgaga attagctcat aaactatctg tggtgtgtgt     2460

ggggaatgaa gttgggggat gtgggggaag agcttatgac tttcccacct gtgtcatcca     2520

ttggaagccc ttgctcttgc actttgcatt aaaagtggga aacattaatc aaagggagat     2580

tttattccca ggttttccct gggactttgt gatatcataa ttgaacagtt cttttgtttt     2640

acatttcaat ttagttgcct catagaagta taactgccca atctatgagt aaagtgtaag     2700

tgtcaaaact ttacaattgc ctccaagtca tattttttgc agaagcacat ttaaagcact     2760

tttctgtaaa agctagttcc ttacctgctt ggaaatcttt ttgtttgttc ttctattcct     2820

ttgttaatca gatgtaatcc ctttctttaa tgtgtatttt tcttggtcca ccatgtttac     2880

agatgggaga cttgagagat acttagcata actggggcag aaagtgtgta agtgaagtat     2940

ttttcaaaga atgcagttat tatctgattg catttgacct tttgaccttt gttacataat     3000

tctacccctc ctacaaattt aattttttta tgaaattttt aggtgacttg taaattcttc     3060

atgtatgagg agttgtgttt attaatgcta ctttttaaat tttcctgtgc catgtggcag     3120

atgtttattc tcttaatgca cttcaggttt gctatctgta aagcctttga cccaggccta     3180

ctgagtcaaa tctacattca gtgtaacatt aaaggtggaa accaaagggt ttgagaaaga     3240

cgaataaggc ctattctcct tctgctgcag actttatctt tcaaaatcat aaaaatgagc     3300

aatggagatc caggctgggt atagacaaga ataattattt tgcaaacaca ttttcctgac     3360

agatttttgg aagtaggaaa aaagtatggc aacagtgtca tgaagattga aactgtaggt     3420

gctttgtgta tgtatgcatg agtgcagatg agtttgagag agaaaaagtg taattgagcc     3480

ctttgctttt gtcagcctgg gaaacagatg cgttcttatt ttttgaagtt gtgtgaccct     3540

ggactgtccc acagcagaag gcagaacaaa cacttatgtt atgctttaat cataagtgga     3600

atggtcacaa ttaataagat attttatata tggcaaagtt ttatgaaatg cttttttact     3660

attagagacc tgtttcttct gttattacag aacacagtgt ttatcaactg cggacataat     3720

tcttttatta tacagttgca tgtaaaggga gcttctcatt taattcagcg gatgtgggta     3780

tttttagggc attgtaattg atggttttaa taattgctga ataatttttg attaagagaa     3840

aaatgtaata caattactgg tctgagttac agaacagaag ttaatgaaaa aggctatttg     3900

agcatgtgta cttatagatt catttgggtg gctgagaaaa gatgctgctt ttgaaataaa     3960

attggtgctg tgtagacact tgtaaccaaa attattttta taacagaact aaaagaagga     4020

gagaagaggc catggacctt tgagtttaca tgttatacct aattgattgt ctgcagctta     4080

tctgtatttt aatattgact ttgtccagat tcagtgagaa catagtattg acattatgag     4140

gcaaaatgct gtcatagcca gtattactga tatgttgcta cagacacaat gtatagaaca     4200

taccttttct aaaataggaa ttatttccag ttatgaaaaa ggaaaagagt aataaagaaa     4260

accaaatcaa aaccaaggga tcctttctac atgtgggtga acggctgcta aagccacagt     4320

agaaaccaat ttttgaattt gaattgttga aatatcctag attgctttaa tggaaaaaat     4380

ccagagtcac atatcttttt tattatcaag tttttgcagc cttttgccag cattgccata     4440

aatacgtaag aaagcagcag atagtataag cccctagtta ttaagacttc tcagttaata     4500

ttaaggccaa aatataactt gagctaggta taacagggct gaatgctaca gtgttgtttt     4560

taaagatttt gcttattttt aaagacagga aaattcagtt ctaaccagat gttccagcta     4620

tgttactcaa ccagcagtgg taggagcaga gagcacttgc actaagagct gatcaccatt     4680

tgagatacgc ggcttaacgc acatgtgagt gtagcttgct acatgaaaat gctaggctct     4740

agggcatgta aaacatgaat acagaatact agattgttct aagtaatgtc atttcggttt     4800

gtgaatttga tttttccctt catttcatgt catattgaaa atgcaaacaa actgctctca     4860

agaacaccca gaagctatct gtgttaccag atgtgttgtg aacactctac tatttttcat     4920

aggtgcttcc ttgaaatata tgtccattgt agtggtggag agggactgga ctctctcagg     4980

ctctttactt gccagttgtc tcccgcagtt aatggaaata tatatacata tatatatata     5040

ttttatttag aatataattt aaacatgaag gtctattctt tgcacttttt attaatatat     5100

atatagataa tctttaaaaa aattaaaatt caagtccatt tt                        5142


<210> 2912
<211> 604
<212> DNA
<213> Homo sapiens

<400> 2912
attttggggg tggttggagg cggtggcggc ggcggcgagg aggggaattt ccttgtgcct       60

ccattcccgg gaggggggag cggcgttgga ggccaccgtt tccagagttt cactctgtca      120

cccaggctcg agtgcagtgg cgtgttctcg gctcactaca acctccgtcc tctgggctca      180

agcagtcctc gcatctcagc ctcccaagga gctgggacct cagcatcaac aacagcaact      240

tgtgattggc ggtgaccgga tattcagttg cacatcccca catcaatgca ctgccaatgg      300

gttatatcct gtgttgtgac ctcatggttt aagtgggaat aaagatgagt ataagcagtg      360

atgaggtcaa cttcttggta tatagatact tgcaagagtc aggattttct cattcagcat      420

ttacctttgg tatagaaagc catatcagtc agtccaatat aaatggtgcc ctcgtcccac      480

ccgctgcatt gatttctatc atccagaaag gtctacagta tgtagaagca gaagttagta      540

ttaatgagga tggtaccttg tttgatggtc gaccaataga gtctctgtcc ctgatagatg      600

ccgt                                                                   604


<210> 2913
<211> 461
<212> DNA
<213> Homo sapiens

<400> 2913
accctctctt gggacctgtc ataagtcgga ccccgggcgc ccggctgcgc agtcccagcc       60

gccttcccca ggcagtggaa ccttcgggct cctgagcttc aggatggttc gtactaagac      120

atggaccctg aagaagcact ttgttggcta tcctactaat agtgactttg agttgaagac      180

agctgagctc ccacccttaa aaaatggaga ggtcctgctt gaagctttgt tcctcaccgt      240

ggatccctac atgagagttg tggaaagtaa aaatgtagcc ctaccaaaag gaactattgt      300

actggcttct ccaggctgga caacgcactc catttctgat gggaaagatc tggaaaagct      360

gctgacagag tggccagaca caataccact gtctttggct ctggggacag ttggcatgcc      420

aggcctgact gcctactttg gcctacttga aatctgtggt g                          461


<210> 2914
<211> 24030
<212> DNA
<213> Homo sapiens

<400> 2914
gctgcccaga gcccccatag agagaggtcc ccgccgccac cctcatggat cagccacagt       60

tcagcggggc gccccgcttt ctcacccggc ccaaggcctt cgtggtgtcg gtgggcaagg      120

acgccaccct cagctgccag atcgtgggta atcccacgcc acaggtgagc tgggagaagg      180

accagcagcc ggtggcggcc ggcgcgcgct tccgtctggc ccaggacggc gacctctacc      240

gcctcactat cctggacctg gcgctgggcg acagtgggca atacgtgtgc cgcgcgcgca      300

atgccatagg cgaggccttc gctgctgtgg gcctgcaggt ggacgcggag gccgcgtgcg      360

ccgagcaggc gccgcacttc ctgctgcggc ccacgtccat ccgcgtgcgc gagggctcag      420

aggccacctt ccgctgccgc gtgggtggct ccccgaggcc ggcagtgagc tggtccaagg      480

acgggcggcg cctgggtgag cccgacggcc cccgcgtgcg cgtggaggag ctcggcgagg      540

caagtgcgct gcgcattcgg gcggcgcggc cgcgcgacgg cggcacttac gaggtccgcg      600

ccgagaaccc gctgggcgct gccagcgccg ccgcggcgct agtggtggac tcggacgccg      660

cggacacggc cagccggccc gggacctcca cggccgcgct cctggcgcac ctgcagcggc      720

ggcgcgaggc tatgcgcgcc gagggcgccc ccgcctcacc gcccagcacc ggcacgcgca      780

cctgcacggt gactgaaggc aagcacgcgc gcctcagctg ctacgtgacc ggcgagccca      840

agcccgagac ggtgtggaag aaggacggcc agctggtgac cgagggccgg cgccacgtgg      900

tgtacgagga cgcgcaggag aacttcgtgc tcaagatcct cttctgcaag cagtcggacc      960

gcggcctcta cacctgcacg gcgtccaacc tcgtgggcca gacctacagc tctgtgctgg     1020

tcgtagtgcg cgagcccgcg gttcccttca aaaagcggct gcaagatctg gaggtgcggg     1080

agaaggagtc ggccacgttc ctatgtgagg tgccccagcc gtccactgag gccgcgtggt     1140

tcaaggagga gacgcggttg tgggcgagcg ccaagtacgg catcgaggag gagggcaccg     1200

agcgccgcct gaccgtgcgc aatgtctcgg ccgacgacga cgcggtgtac atctgcgaga     1260

cgccagaggg cagccgcacg gtggcggagc tcgcagtcca aggaaacctc ctccgaaagc     1320

tccctcggaa gacggcggtg cgcgtgggcg acacggctat gttttgcgtg gagctggcgg     1380

tcccggtggg ccccgtccac tggctgcgga accaggagga agtggtggcg gggggccgcg     1440

tggccatctc cgcggagggc acgcgccaca cactaaccat ctcccagtgc tgcctggagg     1500

atgtgggcca ggtggccttt atggctggcg actgccagac gtccacccag ttctgcgtgt     1560

cggcccccag gaagcctccc ctgcaacccc ctgtggatcc tgtggtaaag gccaggatgg     1620

agagttccgt gattctcagc tggtccccac caccccatgg ggaacgccct gtcactatcg     1680

acggctacct ggtagagaag aagaagcttg gcacctacac ctggatcagg tgccacgagg     1740

ctgaatgggt ggctacacct gagctgaccg tggctgatgt ggcggaggag gggaacttcc     1800

agttccgagt gtccgctctc aacagctttg gtcagagtcc ctacctcgag ttcccgggga     1860

ctgtccacct ggcccccaag ctggccgtga ggacaccgct gaaggcggtg caggcggtag     1920

agggtggcga ggtcactttc tccgtggacc tcacggtggc ctcagcgggt gagtggttcc     1980

tggatgggca ggccctgaag gccagcagtg tgtatgagat ccactgtgat cgcacccggc     2040

acacgctcac catccgggag gtgcccgcca gcctgcacgg ggcgcagctg aagttcgtgg     2100

ccaacggcat tgagagcagc atccggatgg aggtccgggc ggccccaggg ctgactgcca     2160

acaagccgcc agccgcagct gcccgggagg tgctggctcg gctgcacgag gaggcgcagc     2220

tgctggctga gctgtcagat caggctgcgg ctgtgacgtg gctgaaggat ggtcgcacac     2280

tgtccccagg ccccaagtat gaggtgcagg catcggccgg gcggcgggtg ctccttgtgc     2340

gagatgtggc ccgggacgat gcaggcctct acgagtgcgt cagccgcggg ggccgcatcg     2400

cctaccagct ctccgtgcaa ggcctcgcgc gctttctgca caaggacatg gcgggcagct     2460

gtgtggatgc cgtggctggg ggcccggcgc agtttgagtg tgagacctcc gaagcccacg     2520

tccacgtgca ctggtacaag gatggcatgg agctgggcca ctccggtgag cgcttcttgc     2580

aggaggatgt ggggacgcgg caccggctgg tggcagccac agtcaccagg caggatgaag     2640

gcacctactc ctgccgcgtg ggcgaggact ctgtggactt ccggctccgc gtctctgagc     2700

ccaaggtggt gtttgctaag gagcagctgg cacgcaggaa gctgcaggca gaggcaggag     2760

ccagtgccac actgagctgc gaggtggccc aggcccagac ggaggtgacg tggtacaagg     2820

atgggaagaa gctgagctcc agctcgaaag tgtgcatgga ggccacaggc tgcacgcgca     2880

ggctggttgt gcagcaggca ggccaggcgg atgccgggga gtatagctgc gaggctgggg     2940

gccagcggct ctccttccat ctggatgtca aagagcccaa ggtggtgttt gccaaggacc     3000

aggtggcaca cagtgaggtg caggctgagg caggggccag tgccacgctg agctgcgagg     3060

tggcccaggc ccagacggag gtgatgtggt acaaagatgg gaagaagctg agctccagct     3120

tgaaagtgca tgtagaggcc aagggctgca gacggaggct ggtggtgcag caggcaggca     3180

agacagatgc cggggactac agctgcgagg ccaggggcca gagggtctcc ttccgcctgc     3240

acatcacaga gcccaagatg atgtttgcaa aggagcagtc agtgcataat gaggtgcagg     3300

ctgaggcggg ggccagtgcc atgctgagct gtgaggtggc ccaggcccag acggaggtga     3360

cgtggtacaa ggatgggaag aagctgagct ccagctcaaa agtgggcatg gaggtcaaag     3420

ggtgcacacg gaggctggtg ctgccacagg cgggcaaagc agatgctggg gagtacagct     3480

gtgaggctgg gggccagaga gtctccttcc acctgcacat cacagagccc aagggggtgt     3540

ttgcgaagga gcagtcagtg cataatgagg tgcaggctga ggcggggacc actgccatgc     3600

tgagctgtga ggtggcccag ccccagacag aggtgacgtg gtacaaggac gggaagaagc     3660

tgagctccag ctcaaaagta cgcatggagg tcaagggctg cacacgaagg ctggtagtgc     3720

agcaggtggg caaagcagat gctggggagt acagctgcga ggctgggggc cagagagtct     3780

cctttcaact gcacatcaca gagcccaagg cagtgtttgc caaggagcag ttggtgcata     3840

atgaggtgcg gactgaggca ggggccagtg ccacactgag ctgtgaggtg gcccaggccc     3900

agacagaggt gacgtggtac aaggatggga agaagctgag ctccagttcg aaagtgcgca     3960

tagaggctgc gggctgcatg cggcagctgg tggtgcagca ggcaggccag gcagatgctg     4020

gggagtacac ctgtgaggct gggggccagc ggctctcctt ccacctggat gtttcagagc     4080

ccaaggcggt gtttgcaaag gagcagctgg cacacaggaa ggtgcaggcc gaggcggggg     4140

ccattgccac gctgagctgc gaggtggccc aggcccagac agaggtgacg tggtacaagg     4200

acgggaagaa gctgagctcc agctcgaaag ttcgaatgga ggctgtgggc tgcacacgga     4260

ggctggtggt gcagcaggca tgccaggcgg acaccgggga gtatagctgc gaggccgggg     4320

gccagcggct ctccttcagc ctggacgtgg cagagcccaa ggtggtgttt gccaaggagc     4380

agccagtgca cagggaggtg caggcccagg cgggggccag caccacactc agctgcgagg     4440

tggctcaggc ccagacggag gtgatgtggt acaaggacgg gaagaagctg agcttcagct     4500

cgaaagtgcg catggaggct gtgggctgca cacggaggct ggtggtgcag caggcgggcc     4560

aggcggtcgc cggggagtac agctgcgagg cggggagcca gcggctctcc ttccacctgc     4620

acgtggcaga gcccaaggcg gtgtttgcca aggagcagcc agcgagcagg gaggtgcagg     4680

ctgaggcggg gaccagtgcc acgctgagct gcgaggtggc ccaggcccag acagaggtga     4740

cgtggtacaa ggacgggaag aaactgagct ccagctcgaa agtgcgaatg gaggccgtgg     4800

gctgcacacg gaggctggtg gtgcaggagg caggccaggc ggacgccggg gagtacagct     4860

gcaaggccgg ggatcagcgg ctgtccttcc acctgcacgt ggcagagccc aaggtggtgt     4920

ttgccaagga gcagccagca cacagggagg tgcaggctga ggcgggggcc agtgccacgc     4980

tgagctgcga ggtggcccag gcccagacag aggtgacgtg gtacaaggat gggaagaagc     5040

tgagttccag ctcgaaagtg cgcgtggagg ccgtgggctg cacacggagg ctggtggtgc     5100

agcaggcggg ccaggcagag gccggggagt acagctgcga ggcagggggt cagcagctct     5160

ccttccgcct gcaggtggca gagctggagc cccaaatttc agagagaccc tgccgcaggg     5220

agcctctggt ggtcaaggag catgaagaca tcatcctgac cgccacactg gccacaccct     5280

ctgcggccac ggtgacctgg ctcaaggatg gtgtggagat tcgccgcagc aagcggcatg     5340

agacagccag ccagggggac acccacaccc tgaccgtgca tggcgcccag gttctggaca     5400

gcgccatcta cagctgccgt gtgggcgcag aggggcagga cttcccagtg caggtggaag     5460

aggtggccgc caagttctgc cggctgctgg agcctgtgtg cggcgagctg ggtggcacgg     5520

tgacactggc ctgcgagcta agcccagcgt gtgcagaggt ggtgtggcgc tgcggcaaca     5580

cgcagcttcg ggtgggcaag cgcttccaga tggtggccga ggggcccgtg cgctcactca     5640

ctgtgttggg gctgcgcgca gaggacgcag gggagtacgt gtgtgagagc cgtgatgacc     5700

acaccagtgc gcagctcacc gtcagtgtgc cccgagtggt gaagtttatg tctgggctga     5760

gcaccgtggt cgcagaggag ggcggcgagg ccaccttcca gtgcgtggtg tcccccagtg     5820

atgtggcagt cgtgtggttc cgggacggtg ccctgcttca gcccagcgag aagtttgcca     5880

tatcacagag tggcgccagc cacagcctga ccatctcaga cctggtgctg gaggacgcgg     5940

gccagatcac cgtggaggct gagggcgcct catcctctgc tgccctgagg gtccgagagg     6000

cgcctgtgct gttcaaaaag aagctggagc cgcagacggt ggaggagcgg agctcggtga     6060

ccctggaggt ggagctgacg cggccgtggc cggagctgag gtggacacgg aacgcgacgg     6120

ccctggcgcc gggaaagaac gtggagatcc acgccgaggg cgcccgccac cgcctggttc     6180

tgcacaacgt aggttttgcc gaccgtggct tctttggctg cgagacgccg gatgacaaga     6240

cacaggccaa actcaccgtg gagatgcgcc aggtacggct cgtacggggc ctgcaggcag     6300

tggaggcacg ggagcagggc acggctacca tggaggtgca gctgtcgcat gcggacgtgg     6360

atggcagctg gactcgtgac ggtctgcggt tccagcaggg gcccacgtgc cacctggctg     6420

tgcggggccc catgcacacc ctcacactct cggggctgcg gccagaggat agtggcctta     6480

tggtcttcaa ggccgaagga gtgcacacgt cggcgcggct cgtggtcacc gagcttcccg     6540

tgagcttcag ccgcccgctg caggacgtgg tgaccactga gaaggagaag gttaccctgg     6600

agtgcgagct gtcgcgtcct aatgtggatg tgcgctggct gaaggacggt gtggagctgc     6660

gggcaggcaa gacgatggcc atcgcagccc agggcgcctg caggagcctc accatttacc     6720

ggtgcgagtt cgcggatcag ggagtgtatg tgtgtgatgc ccatgatgcc cagagctctg     6780

cctccgtgaa ggtacaagga aggacataca ctctcatcta ccggagagtc ctggcggaag     6840

atgcaggaga gatccaattt gtagccgaaa atgcagaatc gcgagcccag ctccgagtga     6900

aggagctgcc agtgaccctc gtgcgcccgc tgcgggacaa gattgccatg gagaagcacc     6960

gcggtgtgct ggagtgtcag gtgtcccggg ccagcgccca ggtgcggtgg ttcaagggca     7020

gtcaggagct gcagcccggg cccaagtacg agctggtcag tgatggcctc taccgcaagc     7080

tgatcatcag tgatgtccac gcagaggacg aggacaccta cacctgtgac gccggtgatg     7140

tcaagaccag tgcacagttc ttcgtggaag agcaatccat caccattgtg cggggtctgc     7200

aggacgtgac agtgatggag cccgctcctg cctggtttga gtgtgagacc tccatcccct     7260

cagtgcggcc acctaagtgg ctcctgggga agacggtgtt gcaggctggg gggaacgtgg     7320

gcctggagca ggagggcacg gtgcaccggc tgatgctgcg gcggacctgc tccaccatga     7380

ccgggcccgt gcacttcacc gttggcaagt cgcgctcctc tgcccgcctg gtggtctcag     7440

acatccccgt agtcctcaca cggccgttgg agcccaagac agggcgtgag ctgcagtcag     7500

tggtcctgtc ctgcgacttc cggccagccc ccaaggctgt gcagtggtac aaggatgaca     7560

cgcccctgtc tccctctgag aagtttaaga tgagcctgga gggtcagatg gctgagctgc     7620

gcatcctccg gctcatgcct gctgatgctg gtgtctaccg gtgccaggcg ggcagtgccc     7680

acagcagcac tgaggtcact gtggaagcgc gggaggtgac agtgacaggg ccgctacagg     7740

atgcagaggc cacggaggag ggctgggcca gcttctcctg tgagctgtcc cacgaggatg     7800

aggaggtcga gtggtcgctc aacgggatgc ccctgtacaa cgacagcttc catgagatct     7860

cacacaaggg ccggcgccac acgctggtac tgaagagcat ccagcgggct gatgcgggca     7920

tagtacgcgc ctcctccctg aaggtgtcga cctctgcccg cctggaggtc cgagtgaagc     7980

cggtggtgtt cctgaaggcg ctggatgacc tgtccgcaga ggagcgcggc accctggccc     8040

tgcagtgtga agtctctgac cccgaggccc atgtggtgtg gcgcaaagat ggcgtgcagc     8100

tgggccccag tgacaagtat gacttcctgc acacggcggg cacgcggggg ctcgtggtgc     8160

atgacgtgag ccctgaagac gccggcctgt acacctgcca cgtgggctcc gaggagaccc     8220

gggcccgggt ccgcgtgcac gatctgcacg tgggcatcac caagaggctg aagacaatgg     8280

aggtgctgga aggggaaagc tgcagctttg agtgcgtcct gtcccacgag agtgccagcg     8340

acccggccat gtggacagtc ggtgggaaga cagtgggcag ctccagccgc ttccaggcca     8400

cacgtcaggg ccgaaaatac atcctggtgg tccgggaggc tgcaccaagt gatgccgggg     8460

aggtggtctt ctctgtgcgg ggcctcacct ccaaggcctc actcattgtc agagagaggc     8520

cggccgccat catcaagccc ctggaagacc agtgggtggc gccaggggag gacgtggagc     8580

tgcgctgtga gctgtcacgg gcgggaacgc ccgtgcactg gctgaaggac aggaaggcca     8640

tccgcaagag ccagaagtat gatgtggtct gcgagggcac gatggccatg ctggtcatcc     8700

gcggggcctc gctcaaggac gcgggcgagt acacgtgtga ggtggaggct tccaagagca     8760

cagccagcct ccatgtggaa gaaaaagcaa actgcttcac agaggagctg accaatctgc     8820

aggtggagga gaaaggcaca gctgtgttca cgtgcaagac ggagcacccc gcggccacag     8880

tgacctggcg caagggcctc ttggagctac gggcctcagg gaagcaccag cccagccagg     8940

agggcctgac cctgcggctc accatcagtg ccctggagaa ggcagacagc gacacctata     9000

cctgcgacat tggccaggcc cagtcccggg cccagctcct agtgcaaggc cggagagtgc     9060

acatcatcga ggacctggag gatgtggatg tgcaggaggg ctcctcggcc accttccgtt     9120

gccggatctc cccggccaac tacgagcctg tgcactggtt cctggacaag acacccctgc     9180

atgccaacga gctcaatgag atcgatgccc agcccggggg ctaccacgtg ctgaccctgc     9240

ggcagctggc gctcaaggac tcgggcacca tctactttga ggcgggtgac cagcgggcct     9300

cggccgccct gcgggtcact gagaagccaa gcgtcttctc ccgggagctc acagatgcca     9360

ccatcacaga gggtgaggac ttgaccctgg tgtgcgagac cagcacctgc gacattcctg     9420

tgtgctggac caaggatggg aagaccctgc gggggtctgc ccggtgccag ctgagccatg     9480

agggccaccg ggcccagctg ctcatcactg gggccaccct gcaggacagt ggacgctaca     9540

agtgtgaggc tgggggcgcc tgcagcagct ccattgtcag ggtgcatgcg cggccagtgc     9600

ggttccagga ggccctgaag gacctggagg tgctggaggg tggtgctgcc acactgcgct     9660

gtgtgctgtc atctgtggct gcgcccgtga agtggtgcta tggaaacaac gtcctgaggc     9720

caggtgacaa atacagccta cgccaggagg gtgccatgct ggagctggtg gtccggaacc     9780

tccggccgca ggacagcggg cggtactcat gctccttcgg ggaccagact acttctgcca     9840

ccctcacagt gactgccctg cctgcccagt tcatcgggaa actgagaaac aaggaggcca     9900

cagaaggggc cacggccacg ctgcggtgtg agctgagcaa ggcagcccct gtggagtgga     9960

gaaaggggtc cgagaccctc agagatgggg acagatactg tctgaggcag gacggggcca    10020

tgtgtgagct gcagatccgt ggcctggcca tggtggatgc cgcggagtac tcgtgtgtgt    10080

gtggagagga gaggacctca gcctcactca ccatcaggcc catgcctgcc cacttcatag    10140

gaagactgag acaccaagag agcatagaag gggccacagc cacgctgcgg tgtgagctga    10200

gcaaggcggc ccccgtggag tggaggaagg ggcgtgagag cctcagagat ggggacagac    10260

atagcctgag gcaggacggg gctgtgtgcg agctgcagat ctgtggcctg gctgtggcag    10320

atgctgggga gtactcctgt gtgtgtgggg aggagaggac ctctgccact ctcaccgtga    10380

aggccctgcc agccaagttc acagagggtc tgaggaatga agaggccgtg gaaggggcca    10440

cagccatgtt gtggtgtgaa ctgagcaagg tggcccctgt ggagtggagg aaggggcccg    10500

agaacctcag agatggggac agatacatcc tgaggcagga ggggaccagg tgtgagctgc    10560

agatctgtgg cctggccatg gcggacgccg gggagtactt gtgtgtgtgc gggcaggaga    10620

ggacctcagc cacgctcacc atcagggctc tgcctgccag gttcatagaa gatgtgaaaa    10680

accaggaggc cagagaaggg gccacagctg tgctgcagtg tgagctgaac agtgcagccc    10740

ctgtggagtg gagaaagggg tctgagaccc ttagagatgg ggacagatac agcctgaggc    10800

aggacgggac taaatgtgag ctgcagattc gtggcctggc catggcagac actggggagt    10860

actcgtgcgt gtgcgggcag gagaggacct cggctatgct caccgtcagg gctctaccca    10920

tcaagttcac agagggtctg aggaacgaag aggccacaga aggggcaaca gccgtgctgc    10980

ggtgtgagct gagcaagatg gcccccgtgg agtggtggaa ggggcatgag accctcagag    11040

atggagacag acacagcctg aggcaggacg gggccaggtg tgagctgcag atccgcggcc    11100

tcgtggcaga ggacgctggg gagtacctgt gcatgtgcgg gaaggagagg acctcagcca    11160

tgctcaccgt cagggccatg ccttccaagt tcatagaggg tctgaggaat gaagaggcca    11220

cagaagggga cacggccacg ctgtggtgtg agctgagcaa ggcggcaccg gtggagtgga    11280

ggaaggggca tgagaccctc agagatgggg acagacacag cctgaggcag gacgggtcca    11340

ggtgtgagct gcagatccgt ggcctggctg tggtggatgc cggggagtac tcgtgtgtgt    11400

gcgggcagga gaggacctca gccacactca ctgtcagggc cctgcctgcc agattcatag    11460

aagatgtgaa aaaccaggag gccagagaag gggccacggc cgtgctgcaa tgtgagctga    11520

gcaaggcggc ccccgtggag tggaggaagg ggtctgagac cctcagaggt ggggacagat    11580

acagcctgag gcaggatggg accagatgtg agctgcagat tcatggcctg tctgtggcag    11640

acactgggga gtactcgtgt gtgtgcgggc aggagaggac ctcggccaca ctcaccgtca    11700

gggccccaca gccagtgttc cgggagccgc tgcagagtct gcaggcggag gagggctcca    11760

cggccaccct gcagtgtgag ctgtctgagc ccactgctac agtggtctgg agcaagggtg    11820

gcctgcagct gcaggccaat gggcgccggg agccacggct tcagggctgc accgcggagc    11880

tggtgttaca ggacctacaa cgtgaagaca ctggcgaata cacttgcacc tgtggctccc    11940

aggccaccag tgccaccctc actgtcacag ctgcgcctgt gcggttcctc cgagagctgc    12000

agcaccagga ggtggatgag ggaggcaccg cacacttatg ctgcgagctg agccgggcgg    12060

gtgcgagcgt ggagtggcgc aagggctccc tacagctctt cccttgtgcc aagtaccaga    12120

tggtgcagga tggtgcagct gcagagctgc tggtacgcgg agtggagcag gaggatgcgg    12180

gtgactacac gtgtgacacg ggccacacgc agagcatggc cagcctctct gtccgtgtcc    12240

ccaggcccaa gttcaagacc cggcttcaga gtctggagca ggagacaggt gacatagccc    12300

ggctgtgctg tcagctgagt gatgcagagt cgggggccgt ggtgcaatgg ctcaaggagg    12360

gcgtggagct gcatgcgggc cccaagtacg agatgcggag ccagggggcc acgcgggagc    12420

tgctgatcca ccaactggag gccaaggaca cgggcgagta tgcctgtgtg acaggcggcc    12480

agaaaaccgc tgcctccctc agggtcacag agcctgaggt gaccattgta cgggggctgg    12540

ttgatgcgga ggtgacggcc gatgaggatg ttgagttcag ctgtgaggtg tccagggctg    12600

gagccacagg cgtgcagtgg tgcctacagg gcctgccact gcaaagcaat gaggtgacag    12660

aggtggctgt gcgggatggc cgcatccaca ccctgcggct gaagggcgtg acgcccgagg    12720

acgctggcac tgtctccttc catttgggaa accatgcttc ctctgcccag ctcaccgtca    12780

gagctcctga ggtgaccatc ctggagcccc tgcaggacgt gcagctcagt gagggccagg    12840

atgccagctt ccagtgccgg ctatccagag cttcaggcca ggaggcccgc tgggctttag    12900

gaggggtgcc cctgcaggcc aacgagatga atgacatcac tgtggagcag ggcacactcc    12960

acctgctcac cctgcacaag gtgacccttg aggatgctgg aactgtcagt ttccacgtgg    13020

gcacgtgtag ctctgaggcc cagctgaaag tcacagccaa gaacacggtg gtgcgggggc    13080

tggagaatgt ggaggcgctg gagggcggcg aggcgctgtt cgagtgccag ctgtcccagc    13140

ccgaggtggc cgcccacacc tggctgctgg acgacgaacc cgtgcacacc tcggagaacg    13200

ccgaggtggt cttcttcgag aacggcctgc gccacctgct gctgctcaaa aacttgcggc    13260

cacaagacag ctgccgggtg accttcctgg ctggggatat ggtgacgtcc gcattcctca    13320

cggtccgagg ctggcgcctg gagatcctgg agcctctgaa aaacgcggcg gtccgggccg    13380

gcgcacaggc atgcttcacc tgcacgctca gcgaggcggt gcccgtggga gaggcgtcct    13440

ggtacatcaa tggcgcggca gtgcagccgg atgacagcga ctggactgtc accgccgacg    13500

gcagtcacca cgccctactg ctgcgcagcg cccagcccca ccacgccggg gaggtcacct    13560

tcgcttgccg cgacgccgtg gcctctgcgc ggctcaccgt gctgggcctc cctgatcccc    13620

cagaggatgc tgaggtggtg gctcgcagca gccacactgt gacactgtct tgggcagctc    13680

ccatgagtga tggaggcggt ggtctctgtg gctaccgcgt ggaggtgaag gagggggcca    13740

caggccagtg gcggctgtgc cacgagctgg tgcctggacc cgagtgtgtg gtggatggcc    13800

tggcccccgg ggagacctac cgcttccgtg tggcagctgt gggccctgtg ggtgctgggg    13860

aaccggttca cctgccccag acagtgcggc ttgcagagcc accgaagcct gtgcctcccc    13920

agccctcagc ccctgagagc cggcaggtgg cagctggtga agatgtctct ctggagcttg    13980

aggtggtggc tgaggctggt gaggtcatct ggcacaaggg aatggagcgc atccagcccg    14040

gtgggcggtt cgaggtggtc tcccagggtc ggcaacagat gctggtgatc aagggcttca    14100

cggcagaaga ccagggcgag taccactgtg gcctggctca gggctccatc tgccctgcgg    14160

ctgccacctt ccaggtggca ctgagcccag cctctgtgga tgaggcccct cagcccagct    14220

tgccccccga ggcagcccag gagggtgacc tgcacctact gtgggaggcc ctggctcgga    14280

aacgtcgcat gagccgtgag cccacgctgg actccattag cgagctgcca gaggaggacg    14340

gccgctcgca gcgcctgcca caggaggcag aggaggtggc acctgatctc tctgaaggct    14400

actccacggc cgatgagctg gcccgcactg gagatgctga cctctcacac accagctctg    14460

atgatgagtc ccgggcaggc accccttccc tggtcaccta cctcaagaag gctgggaggc    14520

caggcacctc accactggcc agcaaggttg gggccccagc agccccctct gtgaagccac    14580

agcagcagca ggagccactg gctgctgtgc gcccaccact gggagacctg agcaccaaag    14640

acctgggtga tccctcaatg gacaaggcag ctgtgaagat ccaggctgcc tttaagggct    14700

acaaggtccg gaaggagatg aagcagcagg aagggcccat gttctcccac acatttgggg    14760

acaccgaggc acaggtgggg gatgccctgc ggctggagtg tgtcgtggcc agcaaggcag    14820

atgtgcgagc ccgctggctg aaggatggtg tggagctgac cgatgggcgg caccatcaca    14880

tcgaccagct tggggatggc acctgctctc tgctgatcac tggcctggac cgtgctgatg    14940

ctggctgcta cacctgtcag gtgagcaaca agtttggcca ggtgacccac agtgcctgtg    15000

tggtggtcag tgggtcagag agtgaagccg agagctcctc tgggggtgag ctggacgatg    15060

ccttccgccg ggctgcccgt cggctgcacc ggctcttccg caccaaaagt ccggctgaag    15120

tttcagatga ggagctcttc ctgagtgcag acgagggccc tgcagagcca gaggagcccg    15180

cggactggca gacataccgc gaagatgagc atttcatctg catccgtttt gaggcgctca    15240

ctgaggcccg ccaggcggta actcgcttcc aggagatgtt tgccacactg ggcattgggg    15300

tggagatcaa gctggtggaa caggggcctc ggagggtaga gatgtgcatc agcaaagaga    15360

ctcctgcccc tgtggtgcct ccagagccat tgcccagcct actgacttct gacgctgccc    15420

cagtgttcct gactgagttg cagaaccaag aagtgcagga tgggtatcct gtgagctttg    15480

actgcgtggt gacaggtcag cccatgccca gtgtgcgctg gttcaaggat gggaagttgt    15540

tggaggagga tgatcactac atgattaatg aagaccaaca gggtggccat cagctcatca    15600

tcacagccgt ggtgccagca gacatgggcg tctaccgctg cctggccgag aacagcatgg    15660

gtgtctcctc caccaaggct gagctccgtg tggacttgac aagcacagac tatgacactg    15720

cagcagatgc cacggagtcc tcatcctact tcagtgccca aggctacctg tccagccggg    15780

agcaggaggg aacagagtcc accactgatg agggccagct gccccaggtg gtggaggagc    15840

tgagagacct ccaggtggcc cctggcacac gcctggccaa gttccagctc aaggtgaaag    15900

gctaccctgc tcccagatta tactggttca aagatggcca gcccctgacc gcatctgccc    15960

acatccgcat gactgacaag aagatcctgc acaccctgga gatcatctcc gtcacccggg    16020

aggactctgg ccagtatgca gcctatatca gcaatgccat gggtgctgcc tactcgtctg    16080

cccggctgct ggttcgaggc cctgatgagc cagaagagaa gcctgcatca gatgtgcatg    16140

agcagctggt gccgccccga atgctggaga ggttcacccc caagaaagtg aagaaaggct    16200

ccagcatcac cttctctgtg aaggtagaag gacgcccggt gcccaccgtg cactggctca    16260

gggaggaggc tgagagaggc gtgctgtgga ttggccctga cacaccgggc tacaccgtgg    16320

ccagctctgc gcagcagcac agcctggtcc tgctggacgt gggccggcag caccagggca    16380

cctacacatg cattgccagc aacgctgccg gccaggccct ctgctccgcc agcctgcacg    16440

tctcgggcct gcctaaggtg gaggagcagg agaaagtgaa ggaagcgctg atttccactt    16500

tcctgcaggg gaccacacaa gccatctcag cacaggggtt ggaaactgcg agttttgctg    16560

accttggtgg gcagaggaaa gaagagcctc tggctgccaa ggaggccctc ggccacctgt    16620

ccctcgctga ggtgggcaca gaggagttcc tgcagaaact gacctcccag atcactgaga    16680

tggtatcggc caagatcacg caggccaagc tgcaggtgcc cggaggtgac agtgatgagg    16740

actccaagac accatctgca tccccccgcc atggccgatc acggccatcc tccagcatcc    16800

aggagtcttc ctcagagtca gaggacggcg atgcccgagg cgagatcttt gacatctacg    16860

tggtcaccgc tgactacctg cccctagggg ctgagcagga tgccatcacg ctgcgggaag    16920

gccagtatgt ggaggtcctg gatgcagccc acccactgcg ctggcttgtc cgcaccaagc    16980

ccaccaagtc cagcccctca cggcagggct gggtgtcacc agcctacctg gacaggaggc    17040

tcaagctgtc acctgagtgg ggggccgctg aggcccctga gttccctggg gaggctgtgt    17100

ctgaagacga atacaaggca aggctgagct ctgtgatcca ggagctgctg agttctgagc    17160

aggccttcgt ggaggagctg cagttcctgc agagccacca cctgcagcac ctggagcgct    17220

gcccccacgt gcccatagct gtggccggcc agaaggcagt catcttccgc aatgtgcggg    17280

acatcggccg cttccacagc agcttcctgc aggagttgca gcagtgcgac acggacgacg    17340

acgtggccat gtgcttcatc aagaaccagg cggcctttga gcagtacctg gagttcctgg    17400

tggggcgtgt gcaggctgag tcggtggtcg tcagcacggc catccaggag ttctacaaga    17460

aatacgcgga ggaggccctg ttggcagggg acccctctca gcccccgcca ccacctctgc    17520

agcactacct ggagcagcca gtggagcggg tgcagcgcta ccaggccttg ctgaaggagc    17580

tgatccgcaa caaggcgcgg aacagacaga actgcgcgct gctggagcag gcctatgccg    17640

tggtgtctgc cctgccacag cgcgctgaga acaagctgca cgtgtccctc atggagaact    17700

acccaggcac cctgcaggcc ctgggcgagc ccatccgcca gggccacttc atcgtgtggg    17760

agggtgcacc gggggcccgc atgccctgga agggccacaa ccgtcacgtg ttcctcttcc    17820

gcaaccacct ggtaatctgc aagccccggc gagactcccg caccgatacc gtcagctacg    17880

tgttccggaa catgatgaag ctgagcagca tcgacctgaa cgaccaggtg gagggggatg    17940

accgcgcctt cgaggtgtgg caggagcggg aggactcggt gcgcaagtac ctgctgcagg    18000

cacggacagc cattatcaag agctcgtggg tgaaggagat ctgtggcatc cagcagcgtc    18060

tggccctgcc tgtgtggcgg cccccggact ttgaagagga gctggccgac tgcacagccg    18120

agctgggtga gacagtcaag ctggcctgcc gcgtgacggg cacacccaag cctgtcatca    18180

gctggtacaa agatgggaaa gcagtgcagg tggaccccca ccacatcctc attgaagacc    18240

ctgatggctc gtgtgcactc atcctggaca gcctgaccgg tgtggactct ggccagtaca    18300

tgtgcttcgc ggccagcgcc gctggcaact gcagtaccct gggcaagatc ctggtgcaag    18360

tcccaccacg gttcgtgaac aaggtccggg cctcaccctt tgtggaggga gaggacgccc    18420

agttcacctg caccatcgaa ggcgccccgt acccgcagat caggtggtac aaggacgggg    18480

ccctgctgac cactggcaac aagttccaga cactgagtga gcctcgcagc ggcctgctag    18540

tgctggtgat ccgggcggcc agcaaggagg acctggggct ctacgagtgt gagctggtga    18600

accggctggg ctccgcgcgg gctagtgcgg agctgcgcat tcagagcccc atgctgcagg    18660

cccaggagca gtgtcacagg gagcagctcg tggctgcagt ggaagacacc accctggagc    18720

gagcggacca ggaggtcaca tctgtcctga agagactgct gggccccaag gcgccaggcc    18780

cctccacagg ggacctcact ggccctggcc cctgccccag gggggcaccc gcactccagg    18840

aaaccggctc ccagccccca gtcaccggaa cttcggaggc acctgccgtg cccccgaggg    18900

tgccacagcc cctcctccac gaaggcccag agcaggagcc ggaggccatt gccagagccc    18960

aggaatggac tgtgcccatt cggatggagg gtgcagcctg gcccggggca ggcacagggg    19020

agctgctctg ggacgtccac agccacgtgg tcagagagac cacacagagg acctacacat    19080

accaggccat cgacacgcac accgcacggc ccccatccat gcaggtaacc atcgaggatg    19140

tgcaggcaca gacaggcgga acggcccaat tcgaggctat cattgagggc gacccacagc    19200

cctcggtgac ctggtacaag gacagcgtcc agctggtgga cagcacccgg cttagccagc    19260

agcaagaagg caccacatac tccctggtgc tgaggcatgt ggcctcgaag gatgccggcg    19320

tttacacctg cctggcccaa aacactggtg gccaggtgct ctgcaaggca gagctgctgg    19380

tgcttggggg ggacaatgag ccggactcag agaagcaaag ccaccggagg aagctgcact    19440

ccttctatga ggtcaaggag gagattggaa ggggcgtgtt tggcttcgta aaaagagtgc    19500

agcacaaagg aaacaagatc ttgtgcgctg ccaagttcat ccccctacgg agcagaactc    19560

gggcccaggc atacagggag cgagacatcc tggccgcgct gagccacccg ctggtcacgg    19620

ggctgctgga ccagtttgag acccgcaaga ccctcatcct catcctggag ctgtgctcat    19680

ccgaggagct gctggaccgc ctgtacagga agggcgtggt gacggaggcc gaggtcaagg    19740

tctacatcca gcagctggtg gaggggctgc actacctgca cagccatggc gttctccacc    19800

tggacataaa gccctctaac atcctgatgg tgcatcctgc ccgggaagac attaaaatct    19860

gcgactttgg ctttgcccag aacatcaccc cagcagagct gcagttcagc cagtacggct    19920

cccctgagtt cgtctccccc gagatcatcc agcagaaccc tgtgagcgaa gcctccgaca    19980

tttgggccat gggtgtcatc tcctacctca gcctgacctg ctcatcccca tttgccggcg    20040

agagtgaccg tgccaccctc ctgaacgtcc tggaggggcg cgtgtcatgg agcagcccca    20100

tggctgccca cctcagcgaa gacgccaaag acttcatcaa ggctacgctg cagagagccc    20160

ctcaggcccg gcctagtgcg gcccagtgcc tctcccaccc ctggttcctg aaatccatgc    20220

ctgcggagga ggcccacttc atcaacacca agcagctcaa gttcctcctg gcccgaagtc    20280

gctggcagcg ttccctgatg agctacaagt ccatcctggt gatgcgctcc atccctgagc    20340

tgctgcgggg cccacccgac agcccctccc tcggcgtagc ccggcacctc tgcagggaca    20400

ctggtggctc ctccagttcc tcctcctcct ctgacaacga gctcgcccca tttgcccggg    20460

ctaagtcact gccaccctcc ccggtgacac actcaccact gctgcacccc cggggcttcc    20520

tgcggccctc ggccagcctg cctgaggaag ccgaggccag tgagcgctcc accgaggccc    20580

cagctccgcc tgcatctccc gagggtgccg ggccaccggc cgcccagggc tgcgtgcccc    20640

ggcacagcgt catccgcagc ctgttctacc accaggcggg tgagagccct gagcacgggg    20700

ccctggcccc ggggagcagg cggcacccgg cccggcggcg gcacctgctg aagggcgggt    20760

acattgcggg ggcgctgcca ggcctgcgcg agccactgat ggagcaccgc gtgctggagg    20820

aggaggccgc cagggaggag caggccaccc tcctggccaa agccccctca ttcgagactg    20880

ccctccggct gcctgcctct ggcacccact tggcccctgg ccacagccac tccctggaac    20940

atgactctcc gagcaccccc cgcccctcct cggaggcctg cggtgaggca cagcgactgc    21000

cttcagcccc ctccgggggg gcccctatca gggacatggg gcaccctcag ggctccaagc    21060

agcttccatc cactggtggc cacccaggca ctgctcagcc agagaggcca tccccggaca    21120

gcccttgggg gcagccagcc cctttctgcc accccaagca gggttctgcc ccccaggagg    21180

gctgcagccc ccacccagca gttgccccat gccctcctgg ctccttccct ccaggatctt    21240

gcaaagaggc ccccttagta ccctcaagcc ccttcttggg acagccccag gcaccccctg    21300

cccctgccaa agcaagcccc ccattggact ctaagatggg gcctggagac atctctcttc    21360

ctgggaggcc aaaacccggc ccctgcagtt ccccagggtc agcctcccag gcgagctctt    21420

cccaagtgag ctccctcagg gtgggctcct cccaggtggg cacagagcct ggcccctccc    21480

tggatgcgga gggctggacc caggaggctg aggatctgtc cgactccaca cccaccttgc    21540

agcggcctca ggaacaggcg accatgcgca agttctccct gggtggtcgc gggggctacg    21600

caggcgtggc tggctatggc acctttgcct ttggtggaga tgcagggggc atgctggggc    21660

aggggcccat gtgggccagg atagcctggg ctgtgtccca gtcagaggag gaggagcagg    21720

aggaggccag ggctgagtcc cagtcggagg agcagcagga ggccagggct gagagcccac    21780

tgccccaggt cagtgcaagg cctgtgcctg aggtcggcag ggctcccacc aggagctctc    21840

cagagcccac cccatgggag gacatcgggc aggtctccct ggtgcagatc cgggacctgt    21900

caggtgatgc ggaggcggcc gacacaatat ccctggacat ttccgaggtg gaccccgcct    21960

acctcaacct ctcagacctg tacgatatca agtacctccc attcgagttt atgatcttca    22020

ggaaagtccc caagtccgct cagccagagc cgccctcccc catggctgag gaggagctgg    22080

ccgagttccc ggagcccacg tggccctggc caggtgaact gggcccccac gcaggcctgg    22140

agatcacaga ggagtcagag gatgtggacg cgctgctggc agaggctgcc gtgggcagga    22200

agcgcaagtg gtcctcgccg tcacgcagcc tcttccactt ccctgggagg cacctgccgc    22260

tggatgagcc tgcagagctg gggctgcgtg agagagtgaa ggcctccgtg gagcacatct    22320

cccggatcct gaagggcagg ccggaaggtc tggagaagga ggggcccccc aggaagaagc    22380

caggccttgc ttccttccgg ctctcaggtc tgaagagctg ggaccgagcg ccgacattcc    22440

taagggagct ctcagatgag actgtggtcc tgggccagtc agtgacactg gcctgccagg    22500

tgtcagccca gccagctgcc caggccacct ggagcaaaga cggagccccc ctggagagca    22560

gcagccgtgt cctcatctct gccaccctca agaacttcca gcttctgacc atcctggtgg    22620

tggtggctga ggacctgggt gtgtacacct gcagcgtgag caatgcgctg gggacagtga    22680

ccaccacggg cgtcctccgg aaggcagagc gcccctcatc ttcgccatgc ccggatatcg    22740

gggaggtgta cgcggatggg gtgctgctgg tctggaagcc cgtggaatcc tacggccctg    22800

tgacctacat tgtgcagtgc agcctagaag gcggcagctg gaccacactg gcctccgaca    22860

tctttgactg ctgctacctg accagcaagc tctcccgggg tggcacctac accttccgca    22920

cggcatgtgt cagcaaggca ggaatgggtc cctacagcag cccctcggag caagtcctcc    22980

tgggagggcc cagccacctg gcctctgagg aggagagcca ggggcggtca gcccaacccc    23040

tgcccagcac aaagaccttc gcattccaga cacagatcca gaggggccgc ttcagcgtgg    23100

tgcggcaatg ctgggagaag gccagcgggc gggcgctggc cgccaagatc atcccctacc    23160

accccaagga caagacagca gtgctgcgcg aatacgaggc cctcaagggc ctgcgccacc    23220

cgcacctggc ccagctgcac gcagcctacc tcagcccccg gcacctggtg ctcatcttgg    23280

agctgtgctc tgggcccgag ctgctcccct gcctggccga gagggcctcc tactcagaat    23340

ccgaggtgaa ggactacctg tggcagatgt tgagtgccac ccagtacctg cacaaccagc    23400

acatcctgca cctggacctg aggtccgaga acatgatcat caccgaatac aacctgctca    23460

aggtcgtgga cctgggcaat gcacagagcc tcagccagga gaaggtgctg ccctcagaca    23520

agttcaagga ctacctagag accatggctc cagagctcct ggagggccag ggggctgttc    23580

cacagacaga catctgggcc atcggtgtga cagccttcat catgctgagc gccgagtacc    23640

cggtgagcag cgagggtgca cgcgacctgc agagaggact gcgcaagggg ctggtccggc    23700

tgagccgctg ctacgcgggg ctgtccgggg gcgccgtggc cttcctgcgc agcactctgt    23760

gcgcccagcc ctggggccgg ccctgcgcgt ccagctgcct gcagtgcccg tggctaacag    23820

aggagggccc ggcctgttcg cggcccgcgc ccgtgacctt ccctaccgcg cggctgcgcg    23880

tcttcgtgcg caatcgcgag aagagacgcg cgctgctgta caagaggcac aacctggccc    23940

aggtgcgctg agggtcgccc cggccacacc cttggtctcc ccgctggggg tcgctgcaga    24000

cgcgccaata aaaacgcaca gccgggcgag                                     24030


<210> 2915
<211> 972
<212> DNA
<213> Homo sapiens

<400> 2915
gcggcggcgg cagcggcagc ggcagcggcg ctgagttttg tctcccgggc cgtctgggcg       60

cgcgcgggtg tcccaggtac cccgccgcct ccctccttcc cgcaggactc gtccctcctg      120

gccctgggcc ccaacggtgc ccgcctgccc ggcggtcggt cagcgcacag ggcacggctt      180

cctctgcttc tcccggacca cttagtctca acccggaatg aaatatgact gaggactctc      240

agagaaactt tcgttcagta tattatgaga aagtggggtt tcgtggagtt gaagaaaaga      300

aatcattaga aattctccta aaagatgacc gtctggatac tgagaaactt tgtactttta      360

gtcagaggtt ccctctcccg tccatgtacc gtgcattggt atggaaggtg cttctaggaa      420

tcttgcctcc acaccacgag tcccatgcca aggtgatgat gtatcgtaag gagcagtact      480

tggatgtcct tcatgccctg aaagtcgttc gctttgttag tgatgccaca cctcaggctg      540

aagtctatct ccgcatgtat cagctggagt ctgggaagtt acctcgaagt ccctcttttc      600

cactggagcc agatgatgaa gtgtttcttg ccatagctaa agccatggag gaaatggtgg      660

aagatagtgt cgactgttac tggatcaccc gacgctttgt gaaccaatta aataccaagt      720

accgggattc cttgccccag ttgccaaaag cgtttgaaca atacttgaat ctggaagatg      780

gcagactgct gactcatctg aggatgtgtt ccgcggcgcc caaacttcct tatgatctct      840

ggttcaagag gtgctttgcg ggatgtttgc ctgaatccag tttacagagg gtttgggata      900

aagttgtgag tggatcctgt aagatcctag tttttgtagc tgtcgaaatt ttattaacct      960

ttaaaataaa ag                                                          972


<210> 2916
<211> 661
<212> DNA
<213> Homo sapiens

<400> 2916
atgcaagctt gctgtggaaa gcatgcttcc cgtctgtcag ggcttcctga gaggagacct       60

ggtgacacag tagcctttcg gcagagctcc ttgggatgag taggaagtgc tgctgcaggt      120

tttgtctggg ggatatctga gccatttctc tgtgggcagc tgtgtttcaa agtctgggca      180

ggttgttgtt gaattttgcg tgggctgcca ggattttgtg gaagtataat actttgtcat      240

tatgagatgt cgtctctcgg tgcctccttt gtgcaaatta aatttgatga cttgcagttt      300

tttgaaaact gcggtggagg aagttttggg agtgtttatc gagccaaatg gatatcacag      360

gacaaggagg tggctgtaaa gaagctcctc aaaatagaga aagaggcaga aatactcagt      420

gtcctcagtc acagaaacat catccagttt tatggagtaa ttcttgaacc tcccaactat      480

ggcattgtca cagaatatgc ttctctggga tcactctatg attacattaa cagtaacaga      540

agtgaggaga tggatatgga tcacattatg acctgggcca ctgatgtagc caaaggaatg      600

cattatttac atatggaggc tcctgtcaag gtgattcaca gagacctcaa gtcaagaaac      660

g                                                                      661


<210> 2917
<211> 1558
<212> DNA
<213> Homo sapiens

<400> 2917
gtccgctgtc cggcctccgg tcacgtgaca gcagcgcagg tgagcgccgc ttccggggtc       60

gggcgcctgg atagctgccg gctccggctt ccacttggtc ggttgcgcgg gagactatgg      120

cgtcctcctc ggtcccacca gccacggtat cggcggcgac agcaggcccc ggcccaggtt      180

tcggcttcgc ctccaagacc aagaagaagc atttcgtgca gcagaaggtg aaggtgttcc      240

gggcggccga cccgctggtg ggtgtgttcc tgtggggcgt agcccactcg atcaatgagc      300

tcagccaggt gcctcccccg gtgatgctgc tgccagatga ctttaaggcc agctccaaga      360

tcaaggtcaa caatcacctt ttccacaggg aaaatctgcc cagtcatttc aagttcaagg      420

agtattgtcc ccaggtcttc aggaacctcc gtgatcgatt tggcattgat gaccaagatt      480

acttgtacat tgtgaagtgc catggcaaca cgcttctgcc ccagttcctg gggatgtacc      540

gagtcagtgt ggacaacgaa gacagctaca tgcttgtgat gcgcaatatg tttagccacc      600

gtcttcctgt gcacaggaag tatgacctca agggttccct agtgtcccgg gaagccagcg      660

ataaggaaaa ggttaaagaa ttgcccaccc ttaaggatat ggactttctc aacaagaacc      720

agaaagtata tattggtgaa gaggagaaga aaatatttct ggagaagctg aagagagatg      780

tggagtttct agtgcagctg aagatcatgg actacagcct tctgctaggc atccacgaca      840

tcattcgggg ctctgaacca gaggaggaag cgcccgtgcg ggaggatgag tcagaggtgg      900

atggggactg cagcctgact ggacctcctg ctcttgtggg ctcctatggc acctccccag      960

agggtatcgg aggctacatc cattcccatc ggcccctggg cccaggagag tttgagtcct     1020

tcattgatgt ctatgccatc cggagtgctg aaggagcccc ccagaaggag gtctacttca     1080

tgggcctcat tgatatcctt acacagtatg atgctaagaa gaaagcagct catgcagcca     1140

aaactgtcaa gcatggggct ggggcagaga tctctactgt ccatccggag cagtatgcta     1200

agcgattcct ggattttatt accaacatct ttgcctaaga gactgcctgg ttctctctga     1260

tgttcaaggt ggtggggttc tgagacactt gggggaattg tggggatatt ctagccacca     1320

gttctcttct tcctttgcta aattcaggct gcaggctcct tccatccaga taactccatc     1380

ctgtcgagta ggctctttct gaccctcaga aatacattgt cctttttcct ctttgcccat     1440

ttttcttccc tctcttcctc cccatgagaa gtctgcttgt agtattagaa tgttattgtt     1500

gactctctcc caagtgcctt gatctttgta atatctcctg ttgtttctat gatatagg       1558


<210> 2918
<211> 793
<212> DNA
<213> Homo sapiens

<400> 2918
gaagccgttt tggggtcgca gcggggtggc agcttgtttt gccttcacgg gagtagaagg       60

aggcggcgtc cggccgcggc cgacggtagt tcgcttcccc gagagtgcgc ggaggcccgg      120

gtgcgaggag ggcctgtttc tcttcagccc tggttcattc acctcgcgga ccgagggccc      180

cgccgtcagg agccggcgac cgtgccctgg tgcgagctgt gatggtcatt gtcctccaga      240

gcagtgatgg aggaaatacc agcccaggaa gcagcagggt caccaagggt ccagtttcag      300

tctttggaga cccagtctga gtgtctgtcc ccagagcctc agtttgtgca ggacaccgac      360

atggaacagg gactcactgg gggatttcca atttccaagc ctgatgggat ctcccagctg      420

gaacaggatc tacaggtctt tgatctggaa actaagacta gagaagtctt aagagatgac      480

tgctcagatg gagagaccag agaagagaac aagctgttga ttcctaagca gaaaatttcg      540

gaagaagtgc attcatacaa agtgagagta ggaagactca aacacgatat tacccaagtt      600

cctgagacta gagaagtgta taagtctgag gacagattag aaagacttca ggaaattcta      660

aggaaatttc tgtacctgga gagagagttt aggcaaataa caatcagcaa ggaaaccttc      720

accagtgaga agaacaatga atgtcatgaa cccgaaaaaa gcttcagtct ggactctact      780

attgatgcag atc                                                         793


<210> 2919
<211> 2696
<212> DNA
<213> Homo sapiens

<400> 2919
agttgcaact tgtctttgag tgcagggaca ggagaagtgt gggctacccg gccactgccc       60

tggagctgtg gtgactgctg cgtttttctc ccatgcactt gcacgtccag gactcctggg      120

agaacttggg ccacactcct tccttgccct cttgagctca ttcgtcaccc tgttgggtga      180

gcacagccct agctcaggcc actgggcaag ccacaccatc caaagaggag gtcctctgcc      240

ccaggacccc cacaccaccc caggcctgct gtggcagctg cggcccagtg acgtggaggt      300

ggagcttctg gcccacactc ggcgggtggt gagccgggag ctggaggagg agacgggact      360

acacacgggc tggatccaga atgggggcct cttcatcgcg tccaaccggc agcgcctgga      420

cgagtacaag aggctcatgt cgctgggcaa ggcgtatggt gtggaatccc atgtgctgag      480

cccggcagag accaagactc tgtacccgct gatgaatgtg gacgacctct acgggaccct      540

gtatgtgccg cacgacggta ccatggaccc cgctggcacc tgtaccaccc tcgccagggc      600

agcttctgcc cgaggagcac aggtcattga gaactgccca gtgaccggca ttcgtgtgtg      660

gacggatgat tttggggtgc ggcgggtcgc gggtgtggag actcagcatg gttccatcca      720

gacaccctgc gtggtcaact gtgcaggagt gtgggcaagt gctgtgggcc ggatggctgg      780

agtcaaggtc ccgctggtgg ccatgcacca tgcctatgtc gtcaccgagc gcatcgaggg      840

gattcagaac atgcccaatg tccgtgatca tgatgcctct gtctacctcc gcctccaagg      900

ggatgccttg tctgtgggtg gctatgaggc caaccccatc ttttgggagg aggtgtcaga      960

caagtttgcc ttcggcctct ttgacctgga ctgggaggtg ttcacccagc acattgaagg     1020

cgccatcaac agggtccccg tgctggagaa gacaggaatc aagtccacgg tctgcggccc     1080

tgaatccttc acgcccgacc acaagcccct gatgggggag gcacctgagc tccgagggtt     1140

cttcctgggc tgtggcttca acagcgcagg aatgatgctg ggtggtggct gtgggcagga     1200

gctggcccac tggatcatcc atgggcgccc ggagaaggac atgcatggct atgacatcag     1260

gcgcttccat cactcgctca cggaccaccc ccgctggatc cgagagcgaa gccatgagtc     1320

ctacgccaag aactactccg tcgtcttccc ccacgatgag ccgctggccg ggcgcaacat     1380

gaggagagac ccgctgcacg aggaactcct tggacaaggc tgcgtgttcc aggagcggca     1440

tggctgggag cgaccgggat ggtttcatcc ccgaggccca gctccggtcc tcgagtacga     1500

ctactacggg gcttacggga gccgcgcgca cgaggactac gcctaccgca ggctgctggc     1560

agacgagtac accttcgcct tcccgcccca ccacgacacg atcaagaagg agtgcctggc     1620

ctgcagaggg gccgccgctg tgtttgacat gtcctacttc gggaagttct acctggtggg     1680

gctggatgca aggaaggctg ccgactggct cttctccgca gatgtcagcc gacccccagg     1740

ctccaccgtg tacacgtgca tgctcaacca ccgtgggggc accgagagtg acctgactgt     1800

cagccgcctg gcacccagcc accaggcctc cccgctggcc cccgcctttg aaggggacgg     1860

ttactacctg gccatgggcg gggccgtggc ccagcacaac tggtcccaca tcaccaccgt     1920

gctgcaggac cagaagtccc agtgccagct catcgacagc tccgaggacc tgggtatgat     1980

cagtatccag ggcccagcca gccgagccat tttgcaggag gtgctggacg cagacctgag     2040

caacgaggcc ttcccgttct ccacccacaa gctactgaga gccgcagggc acctggtccg     2100

agccatgcgg ctgtcctttg tgggggagct gggctgggag ctgcacattc caaaggcgtc     2160

ctgcgtgcct gtgtaccggg ctgtgatggc cgcgggtgcc aagcacggcc tcatcaacgc     2220

agggtaccgc gccatcgact ccctgagcat tgagaaaggc taccggcact ggcacgcgga     2280

cctgcggcca gacgacagcc ccctggaggc aggcctggcc ttcacctgca agctcaagtc     2340

gccggtgccc ttcctgggga gggaggccct ggagcagcag cgggccgcag gcctccgccg     2400

gcgcctggtg tgcttcacca tggaggacaa agtacccatg tttggcctgg aggccatctg     2460

gaggaacggc caagtggtgg gccatgtccg gagggctgac tttgggttcg ccatcgacaa     2520

gaccatcgcc tacggttaca tccatgaccc cagcggtggg ccggtctcgc tggactttgt     2580

gaagagcggg gactatgccc tggagagaat gggggtgacc tatggtgccc aggctcacct     2640

gaagtcgccc ttcgacccca acaacaagag ggtgaaggga atctactgag ggctca         2696


<210> 2920
<211> 664
<212> DNA
<213> Homo sapiens

<400> 2920
actttgatga gcaaggaacg ctgttttaga aaatccttac tacttgatga ttaatccttg       60

gagctaatgt tccacgttcc caaggttgtg agtgcttatg gccacattcc tgcatcagct      120

cagccatcgc ggtttgtcta cagattttga gcgttcgaag ttgacccctg actaagtata      180

ctttgctgct ccctcagcct ttgaaaaaat gtctgtcaca tatgatgatt ccgttggagt      240

agaagtgtcc agcgacagct tctgggaggt cgggaactac aagcggactg tgaagcggat      300

cgacgatggc caccgcctgt gcagcgacct catgaactgc ctgcatgagc gggcgcgcat      360

cgagaaggcg tatgcgcagc agctcactga gtgggcccgg cgctggaggc agctcgtgga      420

gaaagggccc cagtacggga ccgtggagaa ggcctggatg gccttcatgt ccgaggcaga      480

gagggtgagc gagctgcacc tcgaggtgaa ggcctcactg atgaacgatg acttcgagaa      540

gatcaagaac tggcagaagg aagcctttca caagcagatg atgggcggct tcaaggagac      600

caaggaagct gaggacggct ttcggaaggc acagaagccc tgggccaaga agctgaaaga      660

ggta                                                                   664


<210> 2921
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 2921
gagtcaggaa tggagagaag ggtaatggtt ttacctctta ttgtggaaac ctgttgagat       60

cacagagaat atactgacgg cataaaaggg cagaaccata gcagggtgcg cgctgctgta      120

gttgccttcc atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg      180

aacggagacc tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg      240

aagaggaggt gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact      300

gtggccacgt cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc      360

ccgtctgccc actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac      420

tggccagcct ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag      480

aggtgacccg ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact      540

actactgtga ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca      600

ggccccacac ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga      660

accacctgag taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag      720

aagctgatat cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg      780

agtttgagca gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg      840

cgaagctgga gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg      900

agcttgcccg gctggccctg gtcatctccg aactggaggg caaggcgcag cagccagctg      960

cagagctcat gcaggacacg agagacttcc taaacaggta tccacggaag aagttctggg     1020

ttgggaaacc cattgctcga gtggttaaaa aaaagaccgg agaattctca gataaactcc     1080

tctctctgca acgaggcctg agggaattcc aggggaagct gctgagagac ttggaatata     1140

agacagtgag cgtcaccctg gacccacagt cggccagtgg gtacctgcag ctgtcagagg     1200

actggaagtg cgtgacctac accagcctgt acaagagtgc ctacctgcac ccccagcagt     1260

ttgactgtga gcctggggtg ctgggcagca agggcttcac ctggggcaag gtctactggg     1320

aagtggaagt ggagagggag ggctggtctg aggatgaaga agagggggat gaggaggaag     1380

agggagaaga ggaggaggag gaagaggagg ccggctatgg ggatggatat gacgactggg     1440

aaacggacga agatgaggaa tcgttgggcg atgaagagga agaagaggag gaggaagagg     1500

aggaagttct ggaaagctgc atggtggggg tggctagaga ctctgtgaag aggaagggag     1560

acctctccct gcggccagag gatggcgtgt gggcgctgcg cctctcctcc tccggcatct     1620

gggccaacac cagccccgag gctgagcttt tcccagcact gcggccccgg agagtgggca     1680

tcgccctgga ttatgaaggg ggcaccgtga ctttcaccaa cgcagagtca caggaactca     1740

tctacacctt cactgccacc ttcacccggc gcctggtccc cttcctgtgg ctcaagtggc     1800

caggaacacg cctcctgcta agaccctgag ccctgacatc tgcccccagc cccaaccctc     1860

agatgcttca cttctttgga attccaggac tctcaatggg gggacgggat gcctggccta     1920

agcacctgga gcaggggacc ccatatccac tggtagccac ctccccattg ctgtggcccc     1980

ctgaaatctc actcagtgct gttgctccat ctactgccct aatggggctc ttttcccacc     2040

tcctgctggt ttcccgaggg aacttctgac cctggagtcc atgagggctc ctttcctttt     2100

tgaccacgac cttggcccca gctctgcact ctctggaata agggcccgat gcagcatttt     2160

cttgcccagt gtggcaagac ctcagaaaaa ccagtcaatt acgcctaaga tcattttgct     2220

gtccttaaac cccccaggtt ccttcttgca caaatccact ctgctgccca ccttccctgg     2280

cattttaaac agacctaccc caccccaact cagagttaag catacatggc aatgctgaaa     2340

ataaacaaaa tccactgagg cttcccaggc catttaaagc ctggagtacc agcgcatatc     2400

atctcatggg gtccagagtg gagtccaggc ttctctgaaa ccagggctga gcatatttcc     2460

atagccaagg aggtgggact ccctggagct atctgtggtc ttagggaagg atccagacat     2520

acacggcttt ggggtacaag ctgtgatcac tgatcaataa attatctcta gattggtcct     2580

tgtgagggga gttttaagaa tccagaacat cttgctcttg atcagcacat ccaaaaacac     2640

caagacaaac atccagtgga gcagaacctc tcctgcctcg ggagttctga ccaggttccc     2700

cagcagggtg ttaagcctct gtctctggcc ctaccagcat ccaggttcca ctttcctagg     2760

agagagtgga gatgggaaga cagggaaagg aaggcagcag gaggccacaa gcccaccagg     2820

tcttcatgtc aagagaggga gtaacatgtc ttctcattgc ccacggaccc aacctctgtc     2880

caggtgcccc tcatcatcac agtttaacac aagctcccct gctccagcca aattgatctc     2940

ccagtcttgt ccttacccat tccaagtgct ctgccagccc ctgttcatcc aagttttaag     3000

tcctccaccc tgttctaaga gactgttcca acggctctgg gcctcagtgg tcacttgacc     3060

accattgtct cagagctgcc cactttgtgt gtgtcacatg ctgcctgagt cacacgtaca     3120

tcttatttct gcctctagtt ttgtaagctc ctggagggcg gataacatct tatactactc     3180

ttgtattctc atggcaccta gtgcagtgct gggcacagag taggtgctca ataaagactt     3240

gttgaatgaa                                                            3250


<210> 2922
<211> 3905
<212> DNA
<213> Homo sapiens

<400> 2922
ggggtctcgg cgatcgctgc tcctcctcct ccttctcctc ctcttttttc tcctccgcct       60

cctccccccg ccgcctcgcc accgccgcgg ctagggctgg aggcgccgct gtcattcctg      120

tgccggagga accggcgctg ccggtgcctg ggggtcgggg cgcgggcgaa gccgggccgc      180

ggaggacaca acaggtagag ccgggggtgc ccggccgcgc gccccccgcg catcatgcag      240

ctctttgtca cctctctcgc ccccaggcca aaatcctgag catgatggaa gacaataagc      300

agctcgcgct ccgcatcgat ggggcggtcc agtcggccag ccaggaggtg accaacctgc      360

gagccgaact cacggccacc aaccggagac tggcggaact gagcggcggc ggcggccccg      420

gcccgggccc gggagccgcg gccagcgcct cggcggcggg ggactcggcg gcgacgaaca      480

tggagaaccc ccagcttgga gcgcaagtgc tcctgcggga agaagtgtcg cggctccagg      540

aggaagttca ccttctccgg cagatgaagg agatgttggc gaaggacctg gaggagtcgc      600

agggcggcaa gtcctctgag gtcctctcgg ccaccgagct cagggtccag ctggcccaga      660

aggagcagga gctagccaga gccaaagaag ccttgcaggc catgaaagct gatcggaagc      720

gcttaaaggg cgagaagaca gacctggtga gccagatgca gcagctgtat gccacactgg      780

agagccgcga ggagcagctc cgagacttca tccgcaacta tgagcagcac cgcaaggaga      840

gcgaggatgc ggtcaaagcg ctggccaagg agaaggacct gctggagcgt gagaagtggg      900

agctgcggcg ccaagccaag gaggccacag accacgccac ggcactgcgc tcccagctgg      960

acctcaagga caaccggatg aaggagctgg aggccgagct ggccatggcc aaacagtcct     1020

tagctacgct gaccaaggac gtccccaagc ggcattccct cgccatgccg ggcgagacgg     1080

tgctcaatgg caaccaggag tgggtggtgc aggcggacct cccgctgacc gcagccatcc     1140

ggcagagtca acagactctc taccactcac acccccctca ccctgcggac cggcaagcgg     1200

tcagggtgag cccctgccac tcccggcagc cctctgtcat ctccgacgca tctgccgccg     1260

aaggcgaccg gtcgtccaca ccgagcgaca tcaactcccc tcgacaccgg acacactccc     1320

tctgcaacgg cgacagtccc ggcccagttc agaagaacct gcacaaccct attgtacagt     1380

cactagagga tcttgaagac caaaaacgga aaaagaagaa agagaagatg ggattcggct     1440

ccatctcccg cgtcttcgcc agagggaagc agcggaagtc cctcgacccc ggcctctttg     1500

atggtaccgc ccctgattat tacatagagg aggacgcgga ctggtgatac gcgctcccct     1560

gcgcctgctg cccgcaggcg tgtctgtgcg tgtgggcgtg tgtgcaagcg agcgtgggtg     1620

cgcgtgtggc cgtgcgtggg gtgcgtgtgc acgtgtgcgc tggcacacat gggtgctggg     1680

tgtggccgag cgcctctaac aagtgaaaac acgagtgtga acctctctcc cctgcgtcgc     1740

cacctctgta attgatgtac ataccgcaaa ccgtgtgtga acctgtcaac tctctgtcgt     1800

ctttggagcg atacagttgt gttgttaatc tggtttatta tttttcttca gtgtttggtt     1860

tttctttttc tttttgtttg gttcgtcggt ttgtttttgt ttttgttttt ttcccccttt     1920

ctcctcccct cctccttttt atgaaacttg aaaacttgaa ggactgctgt gtatttgtaa     1980

ataacaaaac tattgtgcac tctgtgcttg taaatgtccc tcgtccaaac cgctactcct     2040

ggagcccgtc tggcagagga tgtggtctgt ttttgatgtc ccccctcccg cccccctggt     2100

gtgaacgtgt gggaccagac cctgtcctgg gggtgcgccc aagtcacttt aaccacaaaa     2160

cgccatcgtc gtcagggtaa gctctgctct ctacaaagac tcgcgagccg ggccaagggg     2220

ccttgtcttg gctgggtttg tcagaggtca aaccggctct tttaaacggc ctaccagttt     2280

ttaaattgca ttgccgtttc tttctttatg aaaaaaaaga aaaaaagaaa attgtttcat     2340

ttaatttatt tgcacaaatg ctgaaaactt attctatcta aattattaca taaatattgg     2400

aatgtctatt tttccatggg gtgggcggga ggtgggtgtc tctgttgact tgtctgttct     2460

gttaccatgc tgctacccaa ctgtgcaaag tagtttaggg tggccagaac ccagggacca     2520

ttggatttca aagcttgctt tttctgttgg ttcttctctc tccttctctc tctgtctctc     2580

ccattctcct gcccatgcat gaaaggatcc tccaccttct tcccacccag agctccctcc     2640

aggcctttct ctatatattt atttatctga catacagaac acgactttag tgagcagagt     2700

gctgacagtc atggtcccct tctttgggtc tgtcttttga gagaggttga gttcagggca     2760

agacagcctg ccacacatcc aagggtacga ccagtgggac cctggcctga gtctgttctc     2820

cgaggggcct ccagcagctt ctgttcctcc ctgcagctgt gtctttcttg tcctgggttt     2880

aggatgcagg tgggccaggc aggtgttgtt aggggaggca cccacttcaa aaggagggcc     2940

acagtgggga cacagagtcc agcacctgag ccctccaccc tccccattct ggttggttcc     3000

atcagccaca cttagaatct cccaggatcc cttggactcc gtcccccaac ttgtcacagc     3060

agcctgagcc tacccacccc aggagacaag agctggcagg aacatctgcc tatatggggg     3120

gtggcgttgg ccccaaagag gcttcaccag caaaggaact gtgtgtattt taatgccagg     3180

ggacggagga tgtgtgagct gttcagcaag gtctgcccaa ggcctaaaac tcaatttcct     3240

tattcttttg cttctgctcg tccttaacaa ctaacagctc aacccacacc tctagacaac     3300

agtagtcgtg ctttctgcta acggtgacat tttcagctct taaaaagaag caaggagatt     3360

ttcaaatgct agagtatctc tatcagaagg cataggacat tgtgtccaaa gtctcaagaa     3420

caaacaacac tttccttctg acctggtcca aaagtcagca aacagcaagc aggcagaggc     3480

cctcataagg acttttctgt cctcctttga ccaaactgtt taaccgagcc taggggtgac     3540

ggggagcgac ccaagctggc atctttctct acggagacag attttagaaa atacttttct     3600

tgcccatgaa tttcttttct ggttgatttt tatcattttc cctttactta caagaaaata     3660

agattgcaac cactcctgct aatgatttag tagttccttt tcatttcagt ttttgtaaat     3720

taggagataa ttctaagagt tactaaagga tgatttattt aagagaacta cgtcaaatag     3780

cgaatgagtt atgggtaaca ttagacgaaa ataacctttc ccgtgggaaa ggtttctcga     3840

aggcatggat gcaaatataa aatattaaaa aaaatctaaa taaagcttat tttaaaatat     3900

gatcg                                                                 3905


<210> 2923
<211> 692
<212> DNA
<213> Homo sapiens

<400> 2923
gcgggttgga gcggaagcgc acgcctgcta ggatcagcgg tggtggttcc gcgatggtag       60

gcggcggcgg ggtcggcggc ggcctcctgg agaatgccaa ccccctcatc taccagcgct      120

ctggggagcg gcctgtgacg gcaggcgagg aggacgagca ggttcccgac agcatcgacg      180

cacgcgagat cttcgatctg attcgctcca tcaatgaccc ggagcatcca ctgacgctag      240

aggagttgaa cgtagtagag caggtgcggg ttcaggttag cgaccccgag agtacagtgg      300

ctgtggcttt cacaccaacc attccgcact gcagcatggc cacccttatt ggtctgtcca      360

tcaaggtcaa gcttctgcgc tcccttcctc agcgtttcaa gatggacgtg cacattactc      420

cggggaccca tgcctcagag catgcagtga acaagcaact tgcagataag gagcgggtgg      480

cagctgccct ggagaacacc cacctcttgg aggttgtgaa tcagtgcctg tcagcccgct      540

cctgagcctg gcctttgacc cctcagcctg catactggta tcctggtccc agctcctgcc      600

agggctgtta ccgttgtttt cttgaatcac tcacaatgag aaactaacat tttgcttttt      660

gtaataaagt taatttatat tcagttccca gc                                    692


<210> 2924
<211> 797
<212> DNA
<213> Homo sapiens

<400> 2924
ggctctttcc cttagtaaca gcttttacct tctgcctcaa ttcctctccc cgctcgcgcc       60

cttcccccgc gcgccgcctc cccccgccgc cggccgcgtg cgcccccgcc cctccccccg      120

cggcgggagc acctccgctc gccacctggg gacccgcgcc gcgctccccg cccccgcccg      180

cccggcgccc atcccccgcg ccctccgctc gctggggtta taattgcctc tcaccccccg      240

gaggggttat tttgggggtg gttggaggcg gtggcggcgg cggcgaggag gggaatttcc      300

ttgtgcctcc attcccggga ggggggagcg gcgttggagg ccaccgtttc cagcatcaac      360

aacagcaact tgtgattggc ggtgaccgga tattcagttg cacatcccca catcaatgca      420

ctgccaatga tgaggaaact gaggccttgg actagaacag aggtctcctg actcagtcca      480

ggactctttc tattacatca tgcggcctga tatttgtctt tatggaactc agcaacatca      540

catacagggg ttatatcctg tgttgtgacc tcatggttta agtgggaata aagatgagta      600

taagcagtga tgaggtcaac ttcttggtat atagatactt gcaagagtca ggattttctc      660

attcagcatt tacctttggt atagaaagcc atatcagtca gtccaatata aatggtgccc      720

tcgtcccacc cgctgcattg atttctatca tccagaaagg tctacagtat gtagaagcag      780

aagttagtat taatgag                                                     797


<210> 2925
<211> 1664
<212> DNA
<213> Homo sapiens

<400> 2925
gtgcgcagcg gcgtatgtgg ggccgtgtgc agacccgcgt gtggcgcagg caaggaccct       60

caaaataaac agcctctacc ttgcgagccg tcttccccag gcctgcgtcc gagtctccgc      120

cgctgcgggc ccgctccgac gcggaagatc tgactgcagc catgagcagc aatgagtgct      180

tcaagtgtgg acgatctggc cactgggccc gggaatgtcc tactggtgga ggccgtggtc      240

gtggaatgag aagccgtggc agaggtggtt ttacctcgga tagaggtttc cagtttgttt      300

cctcgtctct tccagacatt tgttatcgct gtggtgagtc tggtcatctt gccaaggatt      360

gtgatcttca ggaggatgcc tgctataact gcggtagagg tggccacatt gccaaggact      420

gcaaggagcc caagagagag cgagagcaat gctgctacaa ctgtggcaaa ccaggccatc      480

tggctcgtga ctgcgaccat gcagatgagc agaaatgcta ttcttgtgga gaattcggac      540

acattcaaaa agactgcacc aaagtgaagt gctataggtg tggtgaaact ggtcatgtag      600

ccatcaactg cagcaagaca agtgaagtca actgttaccg ctgtggcgag tcagggcacc      660

ttgcacggga atgcacaatt gaggctacag cctaattatt ttcctttgtc gcccctcctt      720

tttctgattg atggttgtat tattttctct gaatcctctt cactggccaa aggttggcag      780

atagaggcaa ctcccaggcc agtgagcttt acttgccgtg taaaaggagg aaaggggtgg      840

aaaaaaaccg actttctgca tttaactaca aaaaaagttt atgtttagtt tggtagaggt      900

gttatgtata atgctttgtt aaagaacccc ctttccgtgc cactggtgaa tagggattga      960

tgaatgggaa gagttgagtc agaccagtaa gcccgtcctg ggttccttga acatgttccc     1020

atgtaggagg taaaaccaat tctggaagtg tctatgaact tccataaata actttaattt     1080

tagtataatg atggtcttgg attgtctgac ctcagtagct attaaataac atcaagtaac     1140

atctgtatca ggccctacat agaacataca gttgagtggg agtaaacaaa aagataaaca     1200

tgcgtgttaa tggctgttcg agagaaatcg gaataaaagc ctaaacagga acaacttcat     1260

cacagtgttg atgttggaca catagatggt gatggcaaag gtttagaaca cattattttc     1320

aaagactaaa tctaaaaccc agagtaaaca tcaatgctca gagttagcat aatttggagc     1380

tattcaggaa ttgcagagaa atgcattttc acagaaatca agatgttatt tttgtatact     1440

atatcactta gacaactgtg tttcatttgc tgtaatcagt ttttaaaagt cagatggaaa     1500

gagcaactga agtcctagaa aatagaaatg taattttaaa ctattccaat aaagctggag     1560

gaggaagggg agtttgacta aagttctttt tgtttgtttc aaattttcat taatgtatat     1620

agtgcaaaat accatattaa agaggggaat gtggaggact gaaa                      1664


<210> 2926
<211> 2098
<212> DNA
<213> Homo sapiens

<400> 2926
ggggaatctc acagccctca cctacctcaa cctcagccga aaccagctgt cgctgctgcc       60

accctacatc tgccagctgc ccctgagggt cctcatcgtc agcaacaaca agctgggagc      120

cctgccccct gacatcggca ccctgggaag cctgcgacag cttgacgtga gcagcaacga      180

gctccaatcc ctgccctcgg aactgtgtgg cctctcttcc ctgcgggacc tcaatgtccg      240

gaggaaccag ctcagtacgc tgcccgaaga gctgggggac ctccctctgg tccgcctgga      300

tttctcctgt aaccgcgtct cccgaatccc agtctccttc tgccgcctga ggcacctgca      360

ggtcattctg ctggacagca accctctgca gagtccacct gcccaggtct gcctgaaggg      420

gaaacttcac atcttcaagt atttgtccac agaggccggg cagcgtgggt cggccctggg      480

ggacctggcc ccttctcggc ccccgagttt cagtccctgc cctgcagagg atctatttcc      540

gggacatcgg tacgatggtg ggctggactc aggcttccac agcgttgata gtggcagcaa      600

gaggtggtct ggaaatgagt caacagatga attttcagag ctgtcattcc ggatctcaga      660

gctggcccgg gagccccggg gacccagaga acgcaaggag gatggctcag cggacggaga      720

ccctgtgcag attgacttca tcgacagcca tgtccccggg gaggatgaag agcgaggcac      780

tgtggaggag cagcgaccac ccgaattaag ccctggggca ggggacaggg agagggcacc      840

aagcagcagg cgggaggagc cggcagggga ggagcggcgg cgcccggaca ccttgcagct      900

gtggcaggag cgggaacggc ggcagcagca gcagagcggg gcgtgggggg ccccgaggaa      960

ggatagcggc tcgcctaagt ccagtgcctc ccaagcaggg gctgcagcgg ggcagggagc     1020

ccccgcccct gcccctgcct cccaagagcc ccttcccata gctggaccag cgacagcacc     1080

tgctccacgg ccacttggct ccattcagag accaaacagc ttcctcttcc gttcctcctc     1140

tcagagtggc tcaggccctt cctcaccaga ctctgtcctg agacctcggc ggtaccccca     1200

ggttccagat gagaaggact taatgactca gctgcgccag gtccttgagt cccggctgca     1260

gcggcccctg cctgaggacc tggccaggct ctggccagtg gtcatcctgt gccagctggc     1320

caaccagcta cggccgcgct ccgtgccctt catccatgtg ccctcccctg ctgtgccaaa     1380

actcagtgcc ctcaaggctc ggaagaatgt ggagagtttt ctagaagcct gtcgaaaaat     1440

gggggtgcct gaggctgacc tgtgctcgcc ctcggatctc ctccagggca ctgcccgggg     1500

gctgcggacc gcgctggagg ccgtgaagcg ggtggggggc aaggccctac cgcccctctg     1560

gcccccctct ggtctgggcg gcttcgtcgt cttctacgtg gtcctcatgc tgctgctcta     1620

tgtcacctac actcggctcc tgggttccta ggccccaaaa tcggccctcc ctcacccctt     1680

tcccttcctc tctatttata aggtccctgc tccacccgac cccacctgcg gtgccttcag     1740

ccccaaccaa agacactagt gcaccccctt cacagacact gacctcagag gccccactct     1800

ggtgccccca gaccctgggc ccccagcctc tggcctccct ccagtagccc cacgagtccc     1860

cacctctcag tgctgacggt gccttcatgt ccccgccggc cctgcccctg ccctctgtac     1920

cccgtgaggg gtggcaggag ctggagtctc ccccttcctc ctgtgccctc cccttccccc     1980

cccaacagct gctatggggg ggctaaatta tctctatttt gtagagagga tctatatttg     2040

taggggttcg gggcccaggc cgggtcccta tctctgtgta taaactgtac agaccgtg       2098


<210> 2927
<211> 2371
<212> DNA
<213> Homo sapiens

<400> 2927
acctgctggg agctggagga ggcgcggagc gaagccggcc ctgccagcca cgcggagaag       60

cagaggcagg tgagcgcgat gcagccggcg ccgggtctgg ggctcgggga ctcctccctg      120

caccgctacc tggacggcga cttctggagc ctcaagaacg agctgcgcgg actcctcggc      180

ggcgcccgct cttccggcaa aggtatgatt taagcttgga tgaaatgaga gctttgacag      240

ttcagagagt gaagtttgcc atggacctgc ctctgttaaa acgtgcaggt caggatctgg      300

cagagaaaac aaagaatttt gtcagccgaa gccttgtcat aggagaagtc ctctccatgg      360

cggacatggc cacaggagtg aagtgcggaa taatttattg gctatttggt ggtgctatca      420

ggaatctcgg aagccctgaa catgttacta agtggtttca gccactccag gagcagaaat      480

acactgggat gtttgcaatg accgagaggg gccatgggag caacgcgaga gggatccaga      540

ccgaagccac ctttgacctc tctgcccagg agtttgtaat tgacacgccg tgtgaaaatg      600

cggagaagat gtatattgga aatgccatgt acgggaatta tgcagctgtc tttgcccagc      660

tcatcataga tggaagatct caagggcccc actgtttcat cgttcctgtc cgggatgaaa      720

acggaattgt acccaggagt cacagctatt gatatgatgt acaaggaggg tctgcatggt      780

gtggacaatg ggatattaat atttgacaag gttcggatac ccagggagaa cctgctggat      840

aagtttggtt ccgtggctcc agatggacag taccattcgc ctattaggaa caagagtgca      900

agattcaatg ccatgctggc agcactgacc ccttcgagat tagctgtggc tttccaagct      960

atgggtgcca tgaagcttgg gttgacgata gccattcgct atagccacag ccggaggcag     1020

tttgggccca aaaccaagga agaggtgaag atcattgagc accaaacaca gaccctgcgg     1080

ctgatgcccc acctggccac agccttggcc ctgaccttcg tcagcaggta tgctggggcc     1140

ctcctggatg aggatgtctt ccagggaaag gagctggtca acagtcgctc gctgcaggct     1200

ctggtggcgg ggctgaaggc ctacagcacc tgggagaaca tccgctgcct gcaggactgc     1260

cgcgagtgca ctggaggcat ggttgtgggg cgggaactgc tggcccaata caccaaacag     1320

tatgaagaaa aaccactctt tggcctgctc caaaactggg ctgaatctgt gggggacaag     1380

ctgagaacca gtttcctggc atttaacatg gacacagttg atgatctcgc ctttctgttg     1440

aaagcagtga aatttcgtga aagggttctt cagcggggtt tggtggccag aatttattat     1500

aaggtaaaga ccaagaagga ggattttttc catgcctgga actcgtgtct gcaccacgtg     1560

gcttctctgt ccctggcaca cactcaccga gttaccttag agcagttctc cctagcagtg     1620

aagagctgtc ctgaccaaga ggaccagact ttgttaatga agttttgtct gttgtatgga     1680

accaagctgg tgtttcagga gcgggcctgg tatttagaac ataaatactt gactcccatg     1740

gccagcacga ggatcaggaa tcagttgctg gatttgtgcg actcggtgaa ggatgatgcc     1800

cggagggtga tctcgacctt taacattcca cacacctacc tccacgcacc aatcgccgga     1860

atctccaacc cgcgggccgc gtgggctttc taccctgcac cgctgcagcc gcggccacgg     1920

gaagaggcgc gctcccggcg gcccaagctg ggagccaagc tctaacgggt gtggcgggaa     1980

gtgtggtggc ccgccagcag ctgccacgac gctcgctcca ccgacgccca gagctgtggc     2040

cgaggccggg ggctggcacc cgctgggccg ccactctcgg ggattttggt ggcaaagcgg     2100

aggtcccgcc gaggctggcg aggtgcgcgg ctggctgcta ggaaagagat ccagacggtc     2160

gcctggtgcg ctggatccct gtgccctttc cctgaaaccc agcctggcct gactgcaacc     2220

tctcccaact tcagtgccgg atcccctaga caatcagggt gggctccccg ctgcgagcgc     2280

gccccacagc cgggtgccgc caaaggtctc ctgctgttag cggtgactca cattcccagt     2340

gatttagaaa aactgtggtg ccgagtgaaa g                                    2371


<210> 2928
<211> 2718
<212> DNA
<213> Homo sapiens

<400> 2928
gtatgaggag gaggaggagg aggatgtgaa gatggcggag ctgcagatgc tgctggaaga       60

ggaaatcccg gggggccgcc gggccctctt cgacagctac acaaatctgg aacgggtggc      120

cgattactgc gagaacaact acatacagtc agcagataag cagagagccc tagaagaaac      180

caaagcctac accacccaat ccttagcaag tgttgcctat ctgataaaca ccttggccaa      240

caatgtcctg cagatgctgg atatccaggc atcccagcta cgaaggatgg aatcttcaat      300

caatcatatt tcacaaacag ttgatattca taaagagaaa gttgcaagaa gagaaattgg      360

tattttgact accaataaaa acacttcaag gacacataag attattgctc cagccaacct      420

tgaacgacca gttcgttata ttagaaaacc tattgactat acaattctag atgatattgg      480

acatggagta aagtggttgc ttagatttaa ggtgagtacc cagaacatga agatgggtgg      540

gctgccgcgt acaacacctc caactcagaa gccccctagt ccccctatgt cagggaaagg      600

gacacttggg cggcactccc cctatcgcac actggagcca gtgcgtcctc cagtggtacc      660

aaatgattac gtacctagcc caacccgtaa tatggctccc tcgcagcaga gccctgtgag      720

gacagcttct gtgaatcaaa gaaatcgaac ttacagcagc agtgggagta gtggagggag      780

ccacccaagt agtcggagca gcagtcgaga gaacagtgga agtggtagtg tgggggttcc      840

tattgctgtt cctactccat ctcctcccag tgtctttcca gacgctgctg ctgggggtgc      900

ccagaccctt gctgatggct tcacttctcc aactccccct gttgtttctt ccactccccc      960

tacaggtcat cctgtacagt tctacagcat gaataggcct gcctctcgcc atactccccc     1020

aacaataggg ggctcgttgc cctatagacg ccctccttcc attacttcac aaacaagcct     1080

tcagaatcag atgaatggag gaccttttta tagccagaat ccagtttcag atacaccacc     1140

tccaccgcca cctgtggaag aaccagtctt tgatgagtct cccccacctc ctcctcctcc     1200

agaagattac gaagaggagg aagctgctgt ggttgagtat agtgatcctt atgctgaaga     1260

ggacccaccg tgggctccac gttcttactt ggaaaaggtt gtggcaattt atgactatac     1320

aaaagacaag gaagatgagc tgtcctttca ggaaggagcc attatttatg tcatcaagaa     1380

gaatgacgat ggttggtatg agggagttat gaatggagtg actgggcttt ttcctgggaa     1440

ttacgttgag tctatcatgc attattctga gtaaagctca gcagggctgt gcttgcctca     1500

caggaatagt caggtcttcc cagattatct gaaggccctg gggattccac tccagtaaag     1560

tagaatgaag gatacaaatg ataaaaatta cacttttttt tttggtttat tccccagtat     1620

taaaaacaaa gcaagctgag tctgaacaaa tggatctttc tgccatcatt tgtacaatgc     1680

tgagctgtct ggattgaaat aaaatgacca tttttatgta tgtcaaaggt ataacagcat     1740

aactgtgtag ccaaaacaaa atcagattaa gactgattca gaaaaatctg ggatctttct     1800

caggaatact gtataccctt gggatttctc ctcctgcaga atctgtggca ttggatgttc     1860

ttcattgcct gtgctaaggg gttaacctca tggcccagtg ggtaccctag ccccttcttt     1920

tcttccactt gtatgaagag gagggaacca acatttaaat accacactta accattttta     1980

caattatttc agatggcttt tttcctctgt gacactgtaa attctgcatt ctctcagcac     2040

ttgagtgcac caaacgagtg aatgctgaac tcacttgcat cccttcatgt ttctgtttgt     2100

ggattataag gatgatgaaa tgtgaaagtc tcccaacact ctgagggtgg tgaacgattg     2160

ccacccgttt gattttaatg tgctgctgca tgagactgca ttgttgctaa tggccagtgt     2220

acccagatgt gaagtgtggt aggctggttc atatgtggag gtgggtgtgt gaagctagac     2280

acgaaggtcc ctaaggttct gaagagactt gaactgtgga aatgctctta gcaggcatcc     2340

cgaacccctg cttcggtgct gttttgagga gtaggatctt ggagttcaga ccaactatga     2400

ctatcatttc cttcactatc tagaaaaacg ctattctact ttggaagaga atagtagtta     2460

ttttcaagtc tcctgacagt cactgggagt acaaggtttg ctaatgtgct ctctggacgt     2520

tattaatggc cagtattagt tgctgctgta ttactgactc gcttagctgt agaaagggta     2580

atactctcct gattttgtat gattggactc ttaagtagct gctgttagtc agaattaaaa     2640

cccatctcag actaagaata taatgaataa gattaatagg ccaaaatatg tatctaatca     2700

cattgataaa aattaata                                                   2718


<210> 2929
<211> 3922
<212> DNA
<213> Homo sapiens

<400> 2929
gcggtacggg ggtggtgccg cgctcctggc cccgcgcggg cggacggcgg aggcgcctcc       60

cagcctgcta tgggatggat gaagaagaga accactatgt ctcgcagctc agggaagtct      120

acagcagctg cgacaccacg gggactggct ttctggaccg ccaggagctg acccagctct      180

gccttaagct tcacctggag cagcagctgc ccgtcctcct gcagacgctt ctcggaaacg      240

accatttcgc cagggttaac tttgaggaat ttaaggaagg ttttgtggct gtgttgtctt      300

caaatgctgg tgttcgcccc tcagatgaag acagtagttc tttggaatca gctgcctcca      360

gtgccatccc tccaaagtat gtgaatggtt ctaagtggta tggccgtcgg agccggcctg      420

agctatgtga cgctgccaca gaagccagac gcgtgccgga gcagcaaacc caggccagcc      480

tgaaaagtca cctctggcgc tcagcgtctc tggagagcgt ggagagtccc aagtcagatg      540

aagaggccga gagcactaaa gaagctcaga atgaattatt tgaagcacaa ggacagctgc      600

agacctggga ttctgaggac tttgggagcc cccagaagtc ctgcagcccc tcctttgaca      660

ccccagagag ccagatccgg ggcgtgtggg aagagctggg ggtgggcagc agcggacacc      720

tgagcgagca ggagctggct gtggtctgcc agagcgtcgg gctccaggga ctcgagaaag      780

aggaactcga agacctgttt aacaaactgg atcaagacgg agacggcaaa gtgagtcttg      840

aggaattcca gcttggcctc ttcagtcatg agcccgcgct acttctagag tcttccactc      900

gggttaaacc gagcaaggct tggtctcatt accaggtccc agaggagagc ggctgccaca      960

ccaccacaac ctcatccctc gtgtccctgt gctccagcct gcgcctcttc tccagcattg     1020

acgatggttc tggcttcgct tttcctgatc aggtcctggc catgtggacc caggagggga     1080

ttcagaatgg cagggagatc ttgcagagcc tggacttcag cgtggacgag aaggtgaacc     1140

ttctggagct gacctgggcc cttgacaacg agctcatgac agtggacagt gccgtccagc     1200

aggcagccct ggcctgctac caccaggagc tgagctacca gcaagggcag gtggagcagc     1260

tggcaaggga gcgtgacaag gcaaggcagg acctggagag ggccgagaag aggaacctgg     1320

agtttgtgaa agagatggac gactgccact ccaccctgga gcagctcacg gagaagaaaa     1380

tcaagcatct ggagcagggg taccgggaaa ggctgagcct cctgcggtct gaggtggagg     1440

cggagcgaga gctgttctgg gagcaggccc acaggcagag ggccgcgctg gagtgggacg     1500

tggggcgcct gcaggctgag gaggctggcc tccgcgagaa gctgaccctg gccctgaagg     1560

aaaacagtcg cctacagaag gagattgtgg aagtggtgga aaagctttcg gattcggaga     1620

ggctggccct gaagctgcag aaggacctgg agtttgtgct gaaggacaag ctggagccac     1680

agagtgcaga gctcctggcc caggaggagc ggttcgcagc agtcctgaag gaatacgagc     1740

tcaagtgccg ggacctgcag gaccgcaacg atgagctgca agctgagctg gaaggcctgt     1800

gggcgcggct gcccaagaac cggcacagcc cctcatggag cccggatggg cgcagacggc     1860

agctccctgg actcggccca gcaggcattt cattcctggg taattctgct ccagtgagta     1920

tagaaacgga gctgatgatg gagcaggtaa aggagcatta ccaagacctc aggacccagc     1980

tggagaccaa ggtaaattac tacgaaaggg aaattgcggc actgaaaagg aactttgaga     2040

aggagaggaa ggacatggag caggctcgca ggcgcgaggt cagcgtgctg gagggtcaga     2100

aggccgacct ggaggagctc cacgagaagt ctcaggaggt catctggggc ctgcaggagc     2160

agctgcagga cacagcccgc ggccccgagc ctgagcagat gggcctggca ccctgctgca     2220

cccaggcact gtgtggcctg gccctgcggc atcacagcca cctgcagcag atcagactgg     2280

agttccatag actttctgaa gaaaacactt tgttgaaaaa cgatctggga agggttcggc     2340

aagagcttga agctgcagaa agtactcacg atgcacagag gaaggaaatt gaggttttaa     2400

agaaagacaa ggaaaaggcc tgctctgaga tggaggtgct caacagacag aatcagaact     2460

acaaggatca attatcccag ctcaatgtca gggttcttca actgggacag gaggcttcta     2520

cccaccaggc ccaaaacgag gagcatcgtg tgaccattca gatgttaaca cagagcctgg     2580

aggaggtggt tcgcagtggg cagcagcaga gtgaccaaat ccaaaaactt agagttgaac     2640

ttgaatgcct gaatcaggaa catcagagcc tgcagctgcc atggtcagag ctgacccaga     2700

cccttgagga aagtcaagac caggtgcagg gagctcacct gaggctgagg caggcccagg     2760

cccagcactt gcaggaggtc cggctggtgc cccaggaccg tgtggccgag ctgcatcgcc     2820

tgctcagcct tcagggagag caggccagga ggcgcctgga tgcacagcgg gaagaacatg     2880

agaaacagct gaaagccaca gaagagcggg tggaagaggc ggagatgatt ctgaagaata     2940

tggaaatgct cctccaagag aaagtggata agctgaagga gcagtttgaa aagaacacga     3000

agtccgacct gctgctgaag gagctgtacg tggagaacgc ccacctggtg agagcacttc     3060

aggccaccga ggagaagcag cgaggcgccg agaaacaaag ccgcctcttg gaagaaaaag     3120

ttcgcgctct caacaaactc gtcagtagga ttgcccccgc agccctctct gtgtaaagac     3180

agattatttt ctaggattca ttcgaaagca catcttttaa attaagccac tgtgctgcct     3240

tagattccgt gggtcatgag ccatgagtcc tgggacatct gaggattggg attctttgtt     3300

caccccgcag atagttaatg aatggtctgc cctgggcaag atggaggtgg gggctggggg     3360

aatatgcatg ttgcagaagc cggcgttttt attagcggtc ctgagtaatt tcccttggca     3420

aaattcccag ttttgccact ctctggagcc agatcctggg agctgtcagc aaggagcagg     3480

taagtgagca gttatggaca gcactttcca tgtggtgctt ccgaccctgg ctgtcagagt     3540

gaaatgtaaa gtcagggctc tgtacagttt tgccatttca ctgttctgct ttaagcttag     3600

cttattagaa ctcttggtgg agggtgcgta cacacattcc agaaaaggct tcactcgctg     3660

ggaacgtcaa cccagcgaga aaggagggga agccccttct ccggggacct tatctgtgga     3720

ctcaggaatg atggtgttta ttgcaaatgc acaatctttt tcccattgaa atgtcatcac     3780

actggaaatt gtactatatg taaaaaaaaa aaaaagtata gttttatatt tgaaatgtat     3840

gcaaattatg gccatatggc tgattggaat gtactactgt aatataaaaa gtcactgtat     3900

ttgcaataaa ttcttttcta tt                                              3922


<210> 2930
<211> 627
<212> DNA
<213> Homo sapiens

<400> 2930
tgctgtggct gctccggagg ctgtggctcc ggctgtggag gccgtggctc cggctgtggg       60

ggctgtggct ccggctgtgg aggctgtggc tctggctgtg ggggctgtgg ctccggctgt      120

ggaggctgtg ggggctgtgg ctccggctgt gcgggctgtg ggggatgcaa agggggctgt      180

ggctcttgcg ggggctccaa gagaggctgt gtctcctgtg gggtgtccaa gggggcctgt      240

ggctcctgtg gggggtccaa ggggggctgt ggctcctgtg gggggtccaa ggggggctgt      300

ggctcctgtg gggggtccaa ggggggctgt ggctcctgtg gggggtccaa ggggggctgt      360

ggttcttatg gctgctccca gtccagctgc tgcaagccct gctgctgctc ctcaggctgt      420

gggtcatcct gctgccagtc cagctgctgt aagccttact gctgccagtc cagctgctgt      480

aagccctact gctgccagtc cagctgctgt aagccctgta gctgcttctc aggctgtgga      540

tcatcctgct gccaatccag ctgctacaag ccctgctgct gccagtccag ctgctgtgtc      600

cccgtgtgct gccagtgtaa gatctga                                          627


<210> 2931
<211> 1710
<212> DNA
<213> Homo sapiens

<400> 2931
agttccgacg aaaaatggcg gggtctcctg agttggtggt ccttgaccct ccatgggaca       60

aggagctcgc ggctggcaca gagagccagg ccttggtctc cgccactccc cgagaagact      120

ttcgggtgcg ctgcacctcg aagcgggctg tgaccgaaat gctacaactg tgcggccgct      180

tcgtgcaaaa gctcggggac gctctgccgg aggagattcg ggagcccgct ctgcgagatg      240

cgcagtggac ttttgaatca gctgtgcaag agaatatcag cattaatggg caagcatggc      300

aggaagcttc agataattgt tttatggatt ctgacatcaa agtacttgaa gatcagtttg      360

atgaaatcat agtagatata gccacaaaac gtaagcagta tcccagaaag atcctggaat      420

gtgtcatcaa aaccataaaa gcaaaacaag aaattctgaa gcagtaccac cctgttgtac      480

atccactgga cctaaaatat gaccctgatc cagttctcaa cgggaatgct ttcaactttt      540

ccccattcaa catgatgttg gctgtggatt tgtcatatat ggtttttatt acttcgagcc      600

cctcatatgg aaaatttgaa atgcagaggg gaaacagtag caaaggagat cagtgaagcc      660

atgaagtcct tgcctgcatt aattgaacaa ggagagggat tttcccaagt tctcaggatg      720

cagcctgtta tccacctcca gaggattcac caagaagtct tttccagttg tcataggaaa      780

ccagatgcta aacctgagaa ctttataaca cagatagaaa ccacaccaac agagactgct      840

tccaggaaaa cctctgacat ggtactgaaa agaaagcaaa ctaaagactg cccccagaga      900

aaatggtatc cattgcggcc aaagaaaatt aatcttgata catgagctct ttctgtttat      960

tttgggagtt gaaaataggc accatcaaca tttagattac agcctaatta atacctagat     1020

aagacttcat ttgaaataag aaataactct tttactagtg attcatttat acagatatag     1080

tatctctgtg cggggatatg atataatatt gtatttcctt actgttttat ctattgtaaa     1140

taaaaagcat tttaaaaagt attgacacaa agcccatcag tgggcattaa aaatattaaa     1200

agtgcagact tttactgtcc ttaagtgcca tcaactctca gctcccttgt agcttttgtg     1260

ggatttaaca agtaacaaat tctgttgtgt ttccctggta tacatctttc taggaaaaaa     1320

aaaaaaaaga gagagagctg tataatgatt tttcgtttac atgctgaaaa gtaattatca     1380

gttctgcaca gcagcagatg cagggttttt ttttaaagat gtagtttgat ttatcaaatt     1440

aatgtgctga tgataatact ggctttgact ttgttactcc atgttcagct aatttaggtt     1500

tgtgagatta actttaggat tttttgttgt gtaagacaat gataactatt atttgtgcaa     1560

cattactctt tgaaataaaa attggcatgt agccaatgtt tcctgcccac actcactttt     1620

ttctatagac cattaacata atttgacttg gaactaatgg tttcttttta gggtttctta     1680

tttatttctt tacaaatcat tccagttcaa                                      1710


<210> 2932
<211> 3990
<212> DNA
<213> Homo sapiens

<400> 2932
agcctcgtgt aacaatactt gtgccctggc tgcagtctgc ggggccgcgc cctgggcctg       60

ccgcattcgg ccaacgcaca gcatctgagg agggttatga ccatctggca gatgcagaaa      120

caggcccaga gagggagccc cgcgcggact cactctatga tgtccctgtc ggtgcggccg      180

cagcgccgtc tgctcagcgc ccgggtcaat aggagccagt ccttcgcagg cgtcctcggc      240

agccacgagc gggggcccag gagtttcccg gtcttcagcc cgccggggcc cccacggaag      300

ccccccgcgc tctcccgagt gtccaggatg ttttccgtgg ctcacccagc cgccaaggtg      360

ccgcagcccg agcggctgga cctggtgtac acggcgctga agcggggcct gacggcctac      420

ttggaagtgc accagcagga gcaagagaaa ctccaggggc agataaggga gtccaagagg      480

aattcccgct tgggcttcct gtatgatctg gacaagcaag tcaagtccat tgaacgcttc      540

ctgcgacgac tggagttcca tgccagcaag atcgatgagc tgtatgaggc atactgtgtc      600

cagcggcgtc tccgggatgg tgcctacaac atggtccgtg cctacaccac tgggtccccg      660

ggaagccgag aggcccggga cagcctggca gaggccactc gggggcatcg cgagtacacg      720

gagagcatgt gtctgctgga gagcgagctg gaggcacagc tgggcgagtt tcatctccga      780

atgaaagggc tggctggctt cgccaggctg tgtgtaggcg atcagtatga gatctgcatg      840

aaatatgggc gtcagcgctg gaaactacgg ggccgaattg agggtagtgg aaagcaggtg      900

tgggacagtg aagaaaccat ctttctccct ctactcacgg aatttctgtc tattaaggtg      960

acagaactga agggcctggc caaccatgtg gttgtgggca gtgtctcctg tgagaccaag     1020

gacctgtttg ccgccctgcc ccaggttgtg gctgtggata tcaatgacct tggtaccatc     1080

aagctcagcc tggaagtcac atggagcccc ttcgacaagg atgaccagcc ctcagctgct     1140

tcttctgtca acaaggcctc cacagtcacc aagcgcttct ccacctatag ccagagccca     1200

ccggacacac cctcacttcg ggaacaggct ttctataaca tgctgcgacg gcaggaggag     1260

ctggagaatg ggacagcatg gtccctgtca tctgaatctt cagacgactc atccagccca     1320

cagctctcag gcactgcccg ccactcacca gcccctaggc ccctggtgca gcagcccgag     1380

ccccttccca tccaagttgc cttccgcagg cctgagaccc ccagctctgg gcccttggat     1440

gaggaggggg ccgtggcccc agtcctggca aatgggcatg caccctacag tcggactctg     1500

agccacatca gtgaggctag tgtagatgct gccttggctg aggcttcagt ggaggccgtt     1560

ggcccagaaa gcctagcctg gggacctagc ccacctacac acccagctcc cacccatgga     1620

gagcacccca gtcctgttcc tcctgccctg gaccctggcc actctgccac aagctctacc     1680

ctcggtacaa caggctctgt ccccacatct acagaccctg ccccatctgc acacctagac     1740

tcagttcata agtccacaga ctctggccct tcagaactgc caggccccac tcacaccact     1800

acaggctcta cctatagtgc cattaccact acccacagtg ctccaagccc cctcactcac     1860

actactacag gctccaccca caagcccata atctctaccc ttactactac aggccctacc     1920

ctcaatatca taggcccagt ccagactacc acaagcccca cccacactat gccaagccct     1980

acccatacca cagcaagccc cactcatact tccacaagcc ccacccatac ccccacaagt     2040

cccacccaca aaaccagtat gtcacctccc accactacaa gtcctacccc cagtggtatg     2100

ggcctagtcc agactgccac aagtcccacc catcctacca caagccccac ccatcccacc     2160

acaagcccca tccttataaa tgtaagccct tccacttctc tagaacttgc taccctctcc     2220

agcccctcca aacactcaga ccccaccctc ccaggcactg actcccttcc ctgtagtccc     2280

ccagtctcca attcctacac tcaggcagac cctatggccc ccagaactcc ccacccaagt     2340

cctgcccatt ccagtaggaa acccctcaca agccctgccc cagatccctc agagtctacg     2400

gttcagagtc taagccccac tccctcaccc ccaacccctg caccccagca ttcagacctt     2460

tgcctggcca tggctgtcca gaccccagtc ccaacggcag ccggagggtc tggggacagg     2520

agcctggagg aggcactggg ggccctaatg gctgccctgg atgactaccg tggccagttt     2580

cctgagctgc agggcctgga gcaggaggtg acccgcctag aaagtctgct catgcagaga     2640

caaggtctga ctcgcagccg ggcctccagt ctcagcatca ctgtggagca tgccttggag     2700

agcttcagct tcctcaatga agacgaagat gaagacaatg atgttcctgg ggacaggcct     2760

ccaagcagcc cggaggctgg ggctgaggac agcatagact cacccagtgc ccgccccctc     2820

agcacggggt gtccagctct ggatgctgcc ttggtccggc acctgtacca ctgcagtcgc     2880

ctcctgctga aactgggcac atttgggccc ctgcgctgcc aggaggcatg ggccctggag     2940

cggctgctgc gggaagcccg agtactggag gcagtatgcg agttcagcag gcggtgggag     3000

atcccggcca gctctgccca ggaagtggtg cagttctcgg cctctcggcc tggcttcctg     3060

accttctggg accagtgcac agagagactc agctgcttcc tctgcccggt ggagcgggtg     3120

cttctcacct tctgcaacca gtatggtgcc cgcctctccc tgcgccagcc aggcttggct     3180

gaggctgtgt gtgtgaagtt cctggaggat gccctggggc agaagctgcc cagaaggccc     3240

cagccagggc ctggagagca gctcacagtc ttccagttct ggagttttgt ggaaaccttg     3300

gacagcccca ccatggaggc ctacgtgact gagaccgctg aggaggtgct actggtgcgg     3360

aatctgaact cggatgatca ggctgttgtg ctgaaggccc tgagattggc gcccgagggg     3420

cgtctgcgaa gggacgggct gcgggccctc agctccctgc tcgtccatgg caacaacaag     3480

gtcatggctg ctgtcagcac ccagctccgg agcctgtcac tgggccctac cttccgggag     3540

agggccctcc tgtgcttcct ggaccagctg gaggatgagg acgtgcagac tcgagtggct     3600

ggctgcctgg ccctaggctg catcaaggct cccgagggca ttgagcccct ggtgtacctc     3660

tgccaaactg acacagaagc tgtgagggaa gctgcccggc aaagcctaca gcagtgtgga     3720

gaagagggac agtctgccca tcgacggctg gaggagtccc tggacgccct gccccgcatc     3780

tttgggcctg gcagcatggc cagcacagca ttctaaacta ttcacccatg ggttcctggt     3840

gcccctttcc ccccactttc agggctcacc aggcactggc agggagggta agggctggct     3900

ccagataccc ctcccccaca gattcctagc aatgaaaatc taatatattc ttctgttgcc     3960

cctggggttg gagagtcagt gcctgcagtc                                      3990


<210> 2933
<211> 1137
<212> DNA
<213> Homo sapiens

<400> 2933
agttcagcgc agcgactcgg ggacctggag ctgacgccta gttgctatgg tgacagacta       60

tggggccttt atcaaaatcc caggctgtcg gaagcaaggt ctggtccatc gaactcatat      120

gtcatcctgt cgggtggata agccctctga gatagtagat gttggagata aagtgtgggt      180

gaagcttatt ggccgagaga tgaaaaatga tagaataaaa gtatccctct ccatgaaggt      240

tgtcaatcaa gggactggga aagaccttga tcccaacaat gttatcattg agcaagaaga      300

gaggcggagg cgatccttcc aggattacac tgggcagaag atcacccttg aggctgtctt      360

gaacactacc tgcaagaagt gtggctgtaa aggtagggtg aagcctctgc cctttccacg      420

tttctctcct tgtggatgga cccttttctg gaagaaggag gcagcccagt gccactttgc      480

aaaagattgt ttcatgcaac caggtgggac taaatactct ctgatacctg atgaggaaga      540

ggaaaaggaa gaggcaaagt cagcagagtt tgagaagcct gaccctacaa ggaatccttc      600

tagaaaaaga aagaaggaga agaagaaaaa gaaacataga gataggaagt catctgactc      660

tgacagctca gactctgaga gtgatacagg caagagggca aggcacacat caaaagacag      720

caaggcagca aagaagaaga aaaagaagaa gaagcacaag aagaagcaca aggagtgaga      780

gtataaagag tgtagggggt ggttgagagt aagaaaccag gagccttgtg ccttgagact      840

cctggaaaga ctcaatagtg agaatatagc ctcccacccc attaacttcg ctcccatggg      900

agatggcttc ccctcatgca acaggcaggt ttgggagtta gaggtcaaaa gcagctgcct      960

gaatgagttg ttgtttcctt atcactcctg gtccctttgc aagtgaaccc tgcagctcac     1020

ccattcattc acccaacttc cttcattcag caggaggtcc tattaccctc tccagctgcc     1080

actgccagag ctggattcct gtaaaggagt ccaggctaga gccacagaga ctgttgt        1137


<210> 2934
<211> 573
<212> DNA
<213> Homo sapiens

<400> 2934
gttttggggt cgcagcgggg tggcagcttg ttttgccttc acgggagtag aaggaggcgg       60

cgtccggccg cggccgacgg tagttcgctt ccccgagagt gcgcggaggc ccgggtgcga      120

ggagggcctg tttctcttca gccctggttc attcacctcg cggaccgagg gccccgccgt      180

caggagccgg cgaccgtgcc ctggtgcgag ctggtcttga tggtcattgt cctccagagc      240

agtgatggag gaaataccag cccaggaagc agcagggtca ccaagggtcc agtttcagtc      300

tttggagacc cagtctgagt gtctgtcccc agagcctcag tttgtgcagg acaccgacat      360

ggaacaggga ctcactgggg gatttccaat ttccaagcct gatgggatct cccagctgga      420

acaggatcta caggtctttg atctggaaac taagactaga gaagtcttaa gagatgactg      480

ctcagatgga gagaccagag aagagaacaa gctgttgatt cctaagcaga aaatttcgga      540

agaagtgcat tcatacaaag tgagagtagg aag                                   573


<210> 2935
<211> 4469
<212> DNA
<213> Homo sapiens

<400> 2935
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactacg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggag accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggactac     1680

tgtggctgga cacctctgca cgaggcctgc aactacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg atgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag gcctcagccc gctggagacg ctgcagcagt     1920

gggaagctgt accgcaggga cctggacctg gagacgcggc agaaggccag ggccatggag     1980

atgctgctcc aggcggctgc ctcgggccaa gatccccaca gctcccaggc cttccacacc     2040

ccaagcagcc ttctgtttga ccccgagacc tctcctcctt tgagcccctg cccagaaccc     2100

ccctctaata gcactagact cccagaggcc tctcaggccc atgtcagggt ctccccaggg     2160

caggcggcac cagccatggc caggcctcgg aggagcaggc atgggccagc cagcagcagc     2220

agcagctcag aaggcgagga cagcgcaggc cccgcacggc cgtcccagaa gaggcctcgg     2280

tgctcggcca cagcacaacg ggtggcagcc tggacgcctg gccccgccag caacagggaa     2340

gcagccacag ccagcaccag ccgggcagcc taccaggcag ccatccgggg tgtgggcagt     2400

gctcagagcc ggctggggcc tggcccaccg cggggccaca gcaaagccct tgccccccag     2460

gcagcgctca tcccggagga ggagtgcctg gccggggact ggctggagct ggacatgccc     2520

ctgacccgca gccgccggcc ccgcccccgg ggcactggag acaaccgcag gcccagtagt     2580

acctctgggt cggacagtga ggagagcagg ccccgtgccc gagccaagca ggtccgcctg     2640

acctgcatgc agagttgcag tgcgccagtt aacgcagggc ccagcagcct ggcttcagaa     2700

cctccaggga gccccagcac ccccagggtc tcagagccca gtggggacag ctctgcggca     2760

ggccagccct tgggtccggc cccgccccct cccatccggg ttcgagttca agttcaggat     2820

catctcttcc tcatccctgt cccacacagc agtgacaccc actctgtggc ctggctggcc     2880

gagcaggcgg cccagcgcta ctaccagacc tgcgggctgc tgcccaggct caccctacgg     2940

aaagaggggg ccctgctggc cccacaggac ctcatccctg atgtgctgca gagcaatgac     3000

gaggtgttgg ctgaggtgac ttcgtgggac ctgcccccgt tgactgaccg ctaccgcagg     3060

gcctgccaga gcctggggca aggggagcac caacaggtgc tgcaggccgt ggagctccag     3120

ggcttgggcc tctcgttcag cgcctgctcc ctggccctgg accaggccca gcttacaccc     3180

ctgctgcggg ccctcaagct gcacacagca ctccgggagc tgcgcctggc agggaaccgg     3240

ctgggggaca agtgtgtggc tgagctggtg gctgccctgg gcaccatgcc cagcctggcc     3300

ctccttgacc tctcctccaa tcacctgggt cccgaaggcc tgcgccagct tgccatgggg     3360

ctcccaggcc aagccacctt gcagagtttg gaggagctgg acttaagcat gaaccccctg     3420

ggggacggct gtggccagtc cctggcctcc ctcctgcacg cctgcccctt actcagcacc     3480

ctgcgcctgc aggcgtgtgg cttcggcccc agcttctttc tgagccacca gacagcactg     3540

ggtagtgctt tccaagatgc tgagcacctg aagaccctgt ccctgtccta caacgccctg     3600

ggagcccctg ccctggccag gaccctgcag agcctgcccg ccggcaccct cctgcactta     3660

gagctcagct ccgtggcagc cggcaagggt gattcggacc tcatggagcc tgtattccga     3720

tacctggcca aggaaggctg tgctctagcc cacctgaccc tgtctgcaaa ccacctgggg     3780

gacaaggctg ttagagacct gtgcagatgt ctctctctgt gcccctcact catctcactg     3840

gatctgtctg ccaaccctga gatcagctgt gccagcttgg aagagctcct gtccaccctc     3900

caaaagcggc cccaaggcct tagcttcctt ggcctgtcag gctgcgccgt ccagggtccc     3960

ctgggcctgg gcctgtggga caagatagcc gcgcagctcc gggaactgca gctgtgcagc     4020

agacgcctct gcgctgagga cagggacgcc ctgcgccagc tgcagcccag tcggccgggc     4080

cccggcgagt gcacgctgga ccacggctcc aagctcttct ttcggcgcct ctgaccctgg     4140

cgctgccttt ccccaccctc accgaagccc ctaataaatg aagctgctgg ccgggcgcgg     4200

tggctcacgc ctgtaatccc aacactttgg gaggcccagg cgggcggatc acgaggtcag     4260

gagatcgaga ccatcctggc taacatggtg aaaccccgtc tctactaaaa ataccaaaaa     4320

ttagccgggc gtggtggtgg aagcctgtag tcccagctac tccggaggct gaggcaggag     4380

aatggcgtga acccgggagg cggagcttgc agtgagccga gatcgcacca ctgcactcca     4440

gcctgggcga cagaccgaga ctccgtctc                                       4469


<210> 2936
<211> 679
<212> DNA
<213> Homo sapiens

<400> 2936
ggggaaatgc cgaccctatt caaaggagtt tggggggttg tggagcattc cagagctctg       60

ggaagattct gtcccgcctg cttaccctca ggcccacacc tccacacaca gccagctctg      120

ggcactgcag aaatgacgct cctctcctcc cagtcttcat cactggtggc cccttctggg      180

tctgtgtctg ccgaaaatcc agagcagagg atgctggaga agagagccaa ggtcatagaa      240

gaacttcttc agacagaaag agactacatt cgggatctgg aaatgtgtat tgagcggatc      300

atggtaccca tgcagcaggc acaggtacca aacattgatt ttgagggact ttttggaaat      360

atgcagatgg tgattaaggt ctcgaagcaa ttattggctg ctctggaaat cagcgatgct      420

gtaggacctg tgtttcttgg tcaccgggat gagcttgagg gaacatacaa gatttactgc      480

cagaatcatg atgaggccat tgcgctgctt gaaatctacg agaaggatga gaagatccag      540

aagcatcttc aggactcctt ggcagatctg aagagcctat acaacgaatg gggatgcaca      600

aattatatta acctgggctc cttcctcatc aaaccagtac agagagtaat gcgttacccg      660

ctgttgctaa tggagttgc                                                   679


<210> 2937
<211> 564
<212> DNA
<213> Homo sapiens

<400> 2937
gtttgtggtg attatttact gtctagaatg gatgttacca gctgcatctc ttaccgaaat       60

tttgcaagtt gtatgggaga ctcccgtttg ttgaataagg ttgatgctta tattcaggag      120

catttgttac aaatttctga agaggaggag tttcttaagc ttccaaggct aaagttggag      180

gtaatgcttg aagataatgt ttgcttgccc agcaatggca aattatatac aaaggtaatc      240

aactgggtgc agcgtagcat ctgggagaat ggagacagtc tggaagagct gatggaagag      300

gttagtttta aagtaaatgg gattcaacca tttttaaaaa ttattttgct ataacatgaa      360

ggattccctt tcacttttat tttataacca tgaccctaaa gaatttaaat tttgctatag      420

gtacccctaa gctgagaaac agggggggtg tccaggtgag ctgaatgaac tgttcagttt      480

ggtcttctgc ttttcttttt ttatttcttt gcttattatg tgctgttaac tttctttaaa      540

gtagcatgta atttgcttta gaaa                                             564


<210> 2938
<211> 579
<212> DNA
<213> Homo sapiens

<400> 2938
ttattgtgac gccgaaaacg gagaaacccc gggtccggcg agaggggctg tgacagtcgg       60

agtcccaagc tgcggttcgg ctgctgccga gaactgcaag gtgtggaata tttctggctt      120

ctagtccaat gccaagtgtg tgacctgtgt tttggcccta catttattta aagcctgaat      180

ttggggagta tctgcaaagc actgaaggtt ttggacattg tcttttcctg ctgttgaaag      240

agaccctctt catatataca acattcaggc tacatgattc cctgaaagat aagaacaatg      300

ttatgttggg gatattggtc tctgggccaa cctggtatca gcaccaacct gcagggaatt      360

gtggctgagc cccaggtgtg tgggttcata tctgacagaa gtgtcaagga agtggcctgt      420

gggggaaacc actctgtgtt cctgctggaa gatggggaag tttacacatg tggtttgaac      480

accaaggggc aactgggcca tgagagggaa ggaaacaagc cagaacaaat tggagctctg      540

gcagatcagc atatcattca tgtggcatgt ggcgagtcc                             579


<210> 2939
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 2939
acggggcggg gacgagctgt cgcgctggtt gctcgtgcag gagcgggacc cggaacagac       60

cgccgtgaga gaggaggggt gccggccggg attcgcggcc cggagctcgg gaccggagtc      120

aggaatggag agaagggtaa tggttttacc tcttattgtg gaaacctgtt gagatcacag      180

agaatatact gacggcataa aagggcagaa ccatagcagg gtgcggttgc ttcattccag      240

cctcgcagtc acctctgtgc cctgctggtt gtcttcccag cgctgctgta gttgccttcc      300

atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg aacggagacc      360

tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg aagaggaggt      420

gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact gtggccacgt      480

cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc ccgtctgccc      540

actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac tggccagcct      600

ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag aggtgacccg      660

ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact actactgtga      720

ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca ggccccacac      780

ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga accacctgag      840

taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag aagctgatat      900

cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg agtttgagca      960

gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg cgaagctgga     1020

gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg agcttgcccg     1080

gctggccctg gtcatctccg aactggaggg caaggcgcag cagc                      1124


<210> 2940
<211> 4090
<212> DNA
<213> Homo sapiens

<400> 2940
gcatgatggg agagtgtgtg gagtgggcgg ggggtctccg cggaggaggt ggaggaggcg       60

gcggcggcgg cggaagaggg cggagggtag tgggatgggg gtcccgcggc agcggtgaaa      120

ctccgggtgg gcgtccatgg tgctgctgcg ctgacagggc tgtgagcagc cggccttccg      180

ctctcaccag ttccgcgtcg gaatagacgg tccttccccg gggagtcagt tcctccccgg      240

gcccctgagc catgcccatc gcagccgccc cgaaggagcc aggtgtaaat taattatttg      300

aaagcaactg aacaatggag ccagacatca ttcgaatgta ctcttcatcc ccaccaccat      360

tagacaatgg agcagaggat gatgatgatg atgaatttgg ggaatttggt gggttttcag      420

aagttagccc ttctggtgta gggtttgttg atttcgatac accagattat actcgtccca      480

aggaagagtt tgtaccttca aaccatttta tgccaattca tgaattctca gaaaatgtag      540

atagccttac aagctttaag tccattaaaa atggtaatga taaggacatc actgctgaac      600

tttctgctcc tgtgaaagga cagtctgatg ttttactttc taccaccagc aaagaaataa      660

tttcatctga aatgttagct acttccattg atggcatgga aagaccagga aatttaaata      720

aagtagtgga gcagagacag aatgttggaa cacttgaaag tttctctcca ggagatttta      780

gaactaatat gaatgttgtt catcaaaaca agcagttaga gagctgcaat ggtgaaaagc      840

ctccttgtct ggagattcta acaaatgggt ttgcagtgtt ggaaactgta aatcctcagg      900

gaacagatga tctggacaat gtagctgatt caaagggacg gaagcctctt agcactcata      960

gcactgagta taatttagac tctgtaccta gtcctgctga ggaatttgca gattttgcca     1020

cattttccaa aaaggaaagg atacaattag aagaaataga atgtgcagtt ttaaatgata     1080

gagaagcact aaccattcgg gaaaacaata aaattaatag agtcaatgaa ctgaattctg     1140

taaaagaagt ggctttgggt agaagcttgg ataacaaagg agacactgat ggagaggatc     1200

aggtttgtgt ttcagaaata agcatagtga ctaacagagg tttcagtgtt gaaaaacaag     1260

gccttccaac actgcaacag gatgaatttt tacagtcagg tgttcagtca aaggcttgga     1320

gtttggtaga ctcagctgat aattcagaag ccattaggag agaacaatgt aaaactgaag     1380

aaaaacttga cttacttact tctaaatgtg ctcacctatg catggattct gttaaaactt     1440

ctgatgatga agttggttct cccaaagaag aaagtagaaa gtttactaat ttccaaagcc     1500

caaacattga ccccacagaa gaaaatgatt tggatgattc tttaagtgta aaaaatggtg     1560

atagtagtaa tgactttgtg acttgcaatg atatcaatga agatgatttt ggtgattttg     1620

gtgactttgg ctctgccagt ggctcaactc caccttttgt tactggtact caagattcaa     1680

tgagtgatgc cacttttgaa gagtcttcag agcactttcc acattttagt gaaccaggtg     1740

atgactttgg agaatttggg gatataaatg ctgtttcttg ccaagaggag acaatattaa     1800

caaagtcaga cctaaaacag acttctgata atttatcaga agaatgtcaa ttggcaagaa     1860

aatctagtgg aacaggcact gaacctgttg caaaacttaa aaatgggcaa gaaggtgaga     1920

ttggacattt tgattctgtg ccaaatattc aggatgactg caatggtttt caagactctg     1980

atgattttgc agacttcagt tcagctggtc ctagccaagt tgtagattgg aatgcttttg     2040

aggatgaaca aaaagatagt tgttcttggg ctgcttttgg agaccagcag gctactgaat     2100

ctcatcatcg aaaggaagcc tggcagtcac ataggacaga tgaaaatatt gatactccag     2160

gaacccccaa aacgcacagt gtaccttcag caacttccaa aggagcagtt gctagtggcc     2220

atttacagga atcagccact tcagttcaga cagctttatt aaaccgcctg gagcgaattt     2280

tcgaagcatg ttttccttcc atacttgtcc ctgatgctga agaggaagtt acttccctga     2340

agcacttgct ggaaacaagc actttgccaa taaaaacgag agaggcctta cctgaaagtg     2400

gggaattgct agatgtgtgg actgagctac aggatatcca tgatgcacat ggcttgagat     2460

accagtgggg cggctcccat agcaacaaga agcttttgtc ctccttggga atagacaccc     2520

gaaacattct cttcacgggc aataagaagc agcctgttat agtgcccatg tatgcagcag     2580

gattgggtat gttagagccc accaaggaac cactgaaacc actttctgct gcagaaaaaa     2640

tagcttccat cggtcagaca gccaccatgt caccagatat gaacacatgt acatctgatc     2700

agttccagga gtctctacca cccgtccagt ttgactggag tagcagtggc cttactaacc     2760

ctttagatgc tagtggaggt tccactcttc tgaaccttga tttctttggg cccgtggatg     2820

acagtagctc tagcagcagc accacaatcc caggtgtgga tccggagttg tatgagttaa     2880

caacttctaa gctggaaatc tccacctcaa gcctcaaagt gactgatgca tttgcaagac     2940

tcatgtctac agtagagaag acaagcacat ctaccagtag gaaaccgaaa agagaagagc     3000

acctaagtga agaagctatc aaggtgatcg ctggccttcc tgacttaaca ttcatgcatg     3060

ccaaggtgtt gatgttccca gccacgttaa caccttccac aagctctcaa gaaaaagcag     3120

acggataact gatgtgaatt ggacagtttc tattgctttt ccttttttcc atcccttccc     3180

taccatcaaa agcatacctg ctctaattaa aaaaaaaaaa aaaaaaaatt caagttcagc     3240

tgatttgttg gtaagccgca ctagaaaggt atacatagta atgtatattt atttacatac     3300

tgaagtccta aatttatatt agaaaaatgt aaataatcgg gggtaaacat ttttgaagat     3360

ttattctttt tgtgttgctg gggtgtatac atttatgtct ttgtgaaata cactggtggt     3420

gtccttctta caaaactttt gaaataaaaa aaaaactcaa atcttcactg tctgtgaaat     3480

ccccttcagt cttttcagat tgcattgact gtcctcttga tttttcatat tacatgtcaa     3540

attacttttg ctatcataaa taagctccaa agtcccccat ttaatttttt tttaattttg     3600

tgtatgatgg gtttcagatc tggcttttgt taacattttg gggctttttt aatcttttca     3660

atctggcgta ttgctgtttg accttttgca aggtacttaa ttgctctttt gttatagggt     3720

atggatcatt gtcagaactt gattggaggg gtttaaagag attgtgtctg tttaaaatca     3780

gtatgattca gagaaggacc aaattatatg aatgtcttac aatggaattt acttgttact     3840

gatttttttg ttctattgta ccactatttt ttgaggattt tgcacagtgt aaaatgacat     3900

aatcatagat tgctatggtt taggctgtat atacagtgaa aactatgggt tttaaatgtt     3960

tggggaaatt cctatggaaa aaagagagac atgtagaaga acctctaaca aggttaatgt     4020

gcatgcccaa ggtcttttga aatttcagtg tgtaaatttc cttttagctt atacaaaaat     4080

aaaataattt                                                            4090


<210> 2941
<211> 946
<212> DNA
<213> Homo sapiens

<400> 2941
cgccttctgc ctgccccctc ggccttcttc acttagcctt cgacggccga gcgccccagg       60

ggtggcggtg ggagtggggt tgttgagcgg cgctggctcc tttcacaaat ggggaaactg      120

aggcttaaag ggcgtctgac tcgccagagc agctcagcct gcagctgcta gcagtggcgt      180

ctcatattag cattgttgtc aaccggaggc ggtgcgagtc cgccggggat tccagatggg      240

gctcctgcgc cgcccgccta tcatttgcgg cctgtattcg cgcgtcgctc ccgcagagcc      300

acctcccagc aggcccacgc ccgcgggggc cccgggctgg cgccgctgtc cctggaatcg      360

atgtgagtca ctgctgacgc tttgcaggag catgcatctc acctcagaaa gtctctgacg      420

ttgctgcgga gcggggagag gatgtttctc tattagccct ttgcttttgc tctggcgctg      480

atcctttgct gaccttggac aaatcaattt acgtttctgt gctccagttt cttggtttat      540

aaaagacggt ctccttctgt cacccaggct ggagtgtagt ggaacgatca ccgctgaact      600

gcagcgtcgg cttcctgggc tcaagcgatc ctcccacctc aacctcccaa gtcatgggga      660

ctacagatgc catcacacct ggctaatttt taaatttttc tgtggagaca gggtctcatt      720

ctgttgccca ggcttgtctc gaaccctggt ctaaagtgat cttcccgcct agcctcccaa      780

aatgttggaa ttacagtctg cagatctcca ggggagccca ccagcctagt caacatggcc      840

tcggaagaca ttgccaagct ggcagagaca cttgccaaga ctcaggtggc cgggggacag      900

ctgagtttca aaggcaagag cctcaaactc aacactgcag aagatg                     946


<210> 2942
<211> 582
<212> DNA
<213> Homo sapiens

<400> 2942
agcagcgcgc aggcgcacgt cagtccccgc gcttttcgga ggctgccagc gtcccacacc       60

agccgcagga tagcagcatc aaggagcatt gtgtacatgc agaagtgcac agtacctgga      120

gtgaaactgc ttgtgttcga tttctgatac cattcataac tggctgtgtg atctcaaata      180

agaaaactga agaaccagct gggcgcggta gctcacgcct gtaatcccag cactttggga      240

ggctgaggcg ggtggattac ctgagaacct ctaaaatgca gacctccagc tctagatctg      300

tgcacctgag tgaatggcag aagaattact tcgcaattac atctggcata tgtaccggac      360

cgaaggcaga tgcataccgt gcacagatat tacgcattca gtatgcatgg gcaaactctg      420

agatttccca ggtctgtgct accaaactgt tcaaaaaata tgcagagaaa tattctgcaa      480

ttattgattc tgacaatgtt gaatctgggt tgaataatta tgcagaaaac attttaactt      540

tggcaggatc tcaacaaaca gatagtgaca agtggcagtc tg                         582


<210> 2943
<211> 603
<212> DNA
<213> Homo sapiens

<400> 2943
gtgcaggagc gggacccgga acagaccgcc gtgagagagg aggggcgccg gccgggattc       60

gcggcccgga gctcgggacc ggagaagaag tcctcaccag tgaacggaga cctctctgaa      120

ctaagaatac catggccacg tcagccccac tacggagcct ggaagaggag gtgacctgct      180

ccatctgtct tgattacctg cgggaccctg tgaccattga ctgtggccac gtcttctgcc      240

gcagctgcac cacagacgtc cgccccatct cagggagccg ccccgtctgc ccactctgca      300

agaagccttt taagaaggag aacatccgac ccgtgtggca actggccagc ctggtggaga      360

acattgagcg gctgaaggtg gacaagggca ggcagccggg agaggtgacc cgggagcagc      420

aggatgcaaa gttgtgcgag cgacaccgag agaagctgca ctactactgt gaggacgacg      480

ggaagctgct gtgcgtgatg tgccgggagt cccgggagca caggccccac acggccgtcc      540

tcatggagaa ggccgcccag ccccacaggg aaaaaatcct gaaccacctg agtaccctaa      600

gga                                                                    603


<210> 2944
<211> 593
<212> DNA
<213> Homo sapiens

<400> 2944
ccggatccgg tctcagctct gggagggaac gggagatgtt gcaggcgccg agagggcggg       60

ccagggccgc actccggaga ctcgcggttg ctacgcgcac catggctgga gcgcccacgg      120

tctcgcttcc tgaactccgt tcactcctag cctccggacg ggcccggctc ttcgacgtgc      180

gctctcgcga ggaggcggca gctgggacca tcccaggggc gctcaacatc ccggtgtccg      240

agttggagag tgctctgcag atggagccag ctgccttcca ggctttatat tctgctgaga      300

agccaaagct ggaagatgag catctcgttt tcttctgtca gatgggcaag cggggcctcc      360

aggccacgca gctggcccgg agtcttggat acactggggc tcgcaactac gctggagcct      420

atagagaatg gttggagaaa gagagttagg caggaggcag cttactgatt gccaccccct      480

ggccccttaa tggccacctt aactaagggt gtgaacgggc tgacttggtg aattgggcaa      540

ctccttatag tgttgtgcac acaaaagcat caaataaaga acatttaatc aaa             593


<210> 2945
<211> 8683
<212> DNA
<213> Homo sapiens

<400> 2945
gcagaagtct gggcagctgc gggaggagag gtttgggagg cgcgggagat gtccaccctg       60

ggctggtggc gccgccgggc gccgggcgcc atgagggtgc gctaggcggc tgttcgtgcc      120

cgaggctgcg cagcactgag gtgagctttg ccttcttgat cttccgtcct tcttggagac      180

gactggcgag aggaagaggg actaggtcca aacgctaggt ggctgggtcc aggtccctga      240

gtactgacgg tcacaggctg ccgcgtcttt cctgttgact catgtttggt tcctccagtg      300

aaaattttac ttagagaaat gctgcctcca aagcacttgt ctgccaccaa acctaagaag      360

tcctgggccc caaatctgta tgagctagac agtgacttga ctaaggagcc ggatgtcatc      420

ataggagaag gtccaactga ctctgagttt tttcatcaga ggtttcggaa cctaatctat      480

gtggaatttg ttgggcctcg gaagaccctg atcaaactcc gaaacctctg cctcgattgg      540

ttgcagccgg agacccgcac caaggaggag atcatcgagc tcttggtcct tgagcagtac      600

ctgaccatca tccctgaaaa gctcaagcct tgggtgcgag caaaaaagcc ggagaactgt      660

gagaagctcg tcactctgct ggagaattac aaggagatgt accaaccaga agacgacaac      720

aacagtgacg tgaccagcga cgacgacatg acccggaaca gaagagagtc ctcaccacct      780

cactcagtcc attctttcag tgaccgggac tgggaccgga ggggcagaag cagagacatg      840

gagccacgag accgctggtc ccacaccagg aacccaagaa gcaggatgcc tccgcgggat      900

ctttcccttc ctgtggtggc gaaaacaagc tttgaaatgg acagagagga cgacagggac      960

tccagggctt atgagtcccg atctcaggat gctgaatcat accaaaatgt ggtggacctc     1020

gctgaggaca ggaaacctca caacacaatc caggacaaca tggaaaacta caggaagctg     1080

ctctccctcg tgcagcttgc tgaagacgat ggccactccc acatgacgca gggccactca     1140

tcaagatcca agagaagtgc ctacccaagc accagtcgag gtctaaaaac tatgcctgaa     1200

gccaaaaaat caacccaccg gcgggggatt tgtgaagatg aatcttccca cggagtgata     1260

atggaaaaat tcatcaagga tgtgtcacgc agttccaaat cgggaagagc aagggagtca     1320

agcgaccggt cacagagatt ccccagaatg tcagatgata actggaagga catttcattg     1380

aacaagaggg agtcagtgat ccagcagcgg gtttatgaag ggaatgcatt taggggaggc     1440

tttaggttta attcaaccct tgtttccaga aagagagttc ttgaaagaaa gaggcgctat     1500

cattttgaca cagatgggaa gggctcgatt cacgatcaaa aaggctgtcc caggaagaag     1560

ccctttgaat gtggtagtga gatgagaaaa gccatgagcg tgagcagcct gagcagcctc     1620

agctccccct cctttaccga gtcacagcca attgattttg gggcaatgcc atatgtatgt     1680

gatgagtgtg ggaggtcgtt cagtgtcatc tcagaatttg ttgagcacca gatcatgcat     1740

actagagaga acctctatga gtatggtgag tcctttatcc acagtgtggc tgtcagtgaa     1800

gttcagaaaa gtcaggttgg agggaaacgt tttgaatgta aggactgtgg agagaccttc     1860

aataagagtg ccgccttggc tgaacatcgg aagattcatg ctagaggtta tcttgtggaa     1920

tgtaagaatc aggaatgtga ggaagccttc atgcctagcc ccacctttag tgagcttcag     1980

aaaatatatg gcaaagacaa attctacgag tgcagggtgt gtaaggaaac cttccttcat     2040

agttctgccc tgattgagca ccagaaaatc cactttgggg atgacaaaga taatgagcgt     2100

gaacatgaac gtgaacgtga acgtgagcgc ggggaaacct ttaggcccag cccagccctt     2160

aatgagtttc agaaaatgta tggtaaagag aaaatgtacg aatgtaaggt gtgtggggag     2220

actttccttc atagctcatc cctgaaagaa catcagaaaa tccatactag agggaaccca     2280

tttgaaaaca agggtaaagt gtgtgaggaa acctttattc ctggtcagtc ccttaaaagg     2340

cgtcagaaaa cttacaataa ggagaagctc tgtgacttta cagatggccg ggatgccttc     2400

atgcaaagct cagagctcag tgagcatcag aaaattcatt ctcgaaagaa cctctttgaa     2460

ggcagagggt atgagaaatc tgtcattcat agtgggccat tcactgaatc tcagaagagt     2520

catactataa caagacctct tgaaagtgat gaggacgaaa aggcgttcac cattagctct     2580

aacccctatg aaaaccagaa gattcccact aaggaaaatg tctatgaggc aaaatcatat     2640

gagaggtctg ttattcatag cttagcctct gtggaagctc agaaaagtca cagtgtagca     2700

gggcccagta aaccaaaagt aatggcagag tctaccattc agagcttcga tgctatcaac     2760

catcagagag ttcgtgctgg agggaacacc tctgaaggaa gggaatacag taggtctgtt     2820

atccatagct tagtggcttc caaacctcca agaagtcaca atggaaatga attggtggaa     2880

tctaatgaga agggagaatc ctccatttat atctcagacc ttaatgataa gcgacagaag     2940

attcctgcca gagagaaccc ttgtgaaggg ggcagtaaga atcgcaacta tgaagactct     3000

gtcatacaga gtgtattccg tgccaaacct cagaaaagtg ttcctggaga gggatctggt     3060

gagtttaaga aggatggcga attctctgtt cccagctcaa atgtccgtga ataccagaag     3120

gctcgtgcta aaaagaaata cattgagcat aggagcaatg agacctctgt aattcactct     3180

ctgccttttg gtgaacaaac atttcgccct cgagggatgc tctatgaatg tcaggagtgt     3240

ggggagtgct ttgctcatag ctctgacctc actgagcacc agaagattca tgatagggag     3300

aagccctctg gaagcagaaa ctatgaatgg tctgtcattc gcagcttggc ccctactgac     3360

cctcaaacaa gttacgccca agagcagtat gctaaagagc aagcgcggaa caaatgtaag     3420

gacttcagac aattttttgc taccagcgaa gacctcaaca caaaccagaa aatctatgac     3480

caagagaagt ctcatggcga ggagtctcaa ggcgagaata ctgatgggga ggagacccac     3540

agcgaggaga cccatggtca ggagacaatt gaagaccctg tcattcaagg ctcagacatg     3600

gaagaccctc agaaggatga ccctgatgac aaaatctatg aatgtgagga ctgtggcctg     3660

ggctttgtgg atctcacaga cctcacagac catcagaaag tccacagcag gaagtgcctg     3720

gttgacagtc gggagtacac acattctgta attcacaccc attccatcag cgagtatcag     3780

agagattaca ctggagagca gctgtatgaa tgtccaaagt gtggggaatc ttttattcat     3840

agctcattcc ttttcgagca tcagagaatc catgaacaag accagttgta ttccatgaag     3900

gggtgtgatg atggttttat tgccctcttg cccatgaagc cacggaggaa tcgtgctgca     3960

gagaggaatc ctgctcttgc tgggtcggcc attcgatgcc ttttgtgtgg acaaggcttc     4020

attcatagct ctgcccttaa tgagcatatg agacttcata gggaagatga tttactggag     4080

cagagccaga tggctgagga agctatcatt ccaggcttag ccctcactga gtttcagaga     4140

agtcagaccg aagagagact ctttgaatgt gcagtctgtg gagaatcttt cgtcaaccca     4200

gcagaacttg cagatcacgt aactgttcat aagaatgagc cctatgagta cgggtcctcc     4260

tatactcaca cctcatttct tactgagccc ctcaaaggag ctataccatt ctatgaatgc     4320

aaggattgtg gtaagtcctt tattcatagc acagtcctca ctaaacataa ggagcttcat     4380

ctggaagaag aagaagaaga tgaagcagca gcagctgcag cagcagcagc ccaggaagtt     4440

gaagccaatg tccatgttcc acaagtagtt ctgaggattc agggcttaaa cgtagaggct     4500

gctgagccag aagtggaggc tgccgagcca gaagtggagg ctgctgagcc agaagtggag     4560

gctgctgagc caaacggaga ggctgaaggg ccagatggag aggctgcaga gcccattgga     4620

gaggctggac agccaaatgg agaggccgag cagccaaatg gggatgctga tgagccagat     4680

ggtgcaggta ttgaagaccc agaagaaaga gctgaagagc cagagggaaa agctgaagag     4740

ccagagggag atgccgacga gcctgacggt gtgggaattg aagacccaga agaaggtgaa     4800

gatcaagaga ttcaggtaga agaaccatac tatgactgcc atgaatgcac agaaaccttc     4860

acttccagca cagcattcag tgaacacctg aaaactcatg ccagcatgat catatttgag     4920

cctgcaaatg cctttgggga gtgctcaggc tacatcgaac gtgccagcac cagcacaggt     4980

ggtgccaatc aagctgatga gaagtacttc aaatgtgacg tctgtgggca gctcttcaat     5040

gaccgcctgt ccctcgccag acaccagaat acccacactg gctgagggca tggggtaaag     5100

gttagaaaac cttcacctag gacttgaccc ttaccaaacc acagagaatc caaaccaatc     5160

catgataatg tcagtaggag acttaacctt agtgtgttac acacctgact taacatctct     5220

aaactcagat tgaaaagaga ccgaatgtgc agattccaca gtcttaagct ttccccttca     5280

gatgtcagtg tctgcatgtg ggaaagccat agcacacatc ttacctttcc aagtaatcag     5340

attgagaaaa ccctatgagt attccagact acagagtttg cccaaatcaa ctgtaaatga     5400

cacttgtgta acgtatatat agtgtttcat gaggtgtata taaaatagca aattatgaca     5460

gaacagtgat cacatatatt tggatttata tgatatacag ttacagttta ctctgcagag     5520

gtaccttacc tggtattctt tgaatttttt ttttttttgg aggaggaaga gagcaacaaa     5580

tttgattata tttttaagtg tcttagatcc tgagaaagat ttattgtgca ttatttgaac     5640

cctgtcaata tctttttgag taattgtttt gtttcttacc cttaaatagt cttgtgaagc     5700

tgtaggcatg atagataaca tggcttttac tccttactgt ttgaaaagat aagtacttta     5760

gcttctttct gcagccattt catctgcgcc aacactttgg aacctaatac tgtgtaaggc     5820

tttacaatat acggattggc tttttgtgac ccagattgat tggttgccac atgttatgtt     5880

tgttgaagtg gttctcatgc aaaaatatta cacatttgtg ttctgggttt tttttttttt     5940

taaccaactc aatatgtgtt tgatgatagt gaattgataa aacccgaagc ttttccctgt     6000

aaatcttaca tctttgcctt taaagaatgg gttacaacca tcactagatc acagtagtgc     6060

ctaatgaagg ttgagaaccg taggagaggc tctcatgctg taaataatgt tgcaggctaa     6120

taacctttca tcacttcctt tgtgcgcttc ctgccttaag tgacaagtag caacatggct     6180

tgggtcccct gtgcagcatc agcttatgct gccacaagtc agtttgcacc ctaggtgccc     6240

aggagctagt atccttagat ctttctatcg ctaacttaat tctcttcgtt atttatctga     6300

ccctctaact ccatgtctaa cttgcattaa aaaaaaaaaa attctttaca gtcaacccaa     6360

gcttaacatg gactcaggtt ccccagcagc cttaatttgt tttgttaaca tctgttcctt     6420

ctttttcagc tctcctagag tatttctgag tgttgtgttc atctaatctt agtattcttt     6480

taattacaaa ttgacctcac agcttgaggt ttcttgtgtc ctattctgtg gactacctgt     6540

gctcctttgc ttcccctccc ctcgcataat aactatatta agaaattttt tttggccttg     6600

agttggctgg aaaaaaaata taaaatttaa aaaatttaaa aaaaaagatt tgcaaaatgt     6660

aagtgtagat catttgaaca agcaaaatta aagtacccac tgggggaaat gtgtctgaat     6720

cttactcttc tggatctgca ggattagggc ttggaagtat gtcaaagatg cagggagtgt     6780

caaagtttag gaagattgta gagctgagag caagaagcag aaatgagtga gtcaaagaag     6840

ggagtcctaa tatatcacca gatctaggag gggagaggag acagacagaa gaaaacacca     6900

gaggcaagaa ctgtagaagg ccaggtttct gagaatgaat tgagcggggt gtcctgagca     6960

gtttggaaaa ggagtttttg atggtatggt gtaggtgagg gctggctgca taggaaggac     7020

tgaggttgga acggacatcg ggaaagctga ggggcagtga ggtttactac atgggaaaag     7080

gactcttgaa acgagaatca gtgttgatgt cggggtgaac tttgtgggta cattacttgg     7140

tgttaacatt gttggcagtg gtagcccctt ttcagaaagc aacttgctgt aagtcagggt     7200

gtccgttcca accttcagct agtgaaaagg tagtaacaaa tggtaaacaa gagaatgatt     7260

gtttaaacct atctgtggac acttaatgca actgtttaaa aatgataatc acgagttatg     7320

tagcaacgtg gaaatatatt tacagaacat taagtggaga aagcaggaca cgaaagtata     7380

tttatactac agttataact caacagttca tttatatgct gttcatttaa cagttcattt     7440

aaacagttca ttataactgt ttaaaaatat atatgcttat agtcaaaagc tgttgtggtg     7500

ttgttgttgt aggcttatag ttgagcatta ttttcttaaa tttcttgaat gttctttatg     7560

gtagtgttac taaaaagttt atgatcacat tttcattgtg aacataattt gaactcatta     7620

tcacacactt ggaaaataca gaaaagtgga ggaaaaaaaa tcatatcccc accatccaaa     7680

gacatatact ctcctcttat cttgttcatt cttgtttctg tgcacaggtt tatgattata     7740

actgtgtcaa aatgtatatt caaaatagct gttacattac ctttgtggaa ttatggttaa     7800

atactttcac tttaattttt tcaaatgttc cctataataa tgtcctgata acagtgtatt     7860

atgtgtgtct ccattggtgt gcataataca tacccagagg aaaaattaga aaataaagta     7920

aattatttta aaaaattacc tatattccca acacctaaca actactgcta acatcttgat     7980

ctgtttcctc tatcttgttt cagtgcacac gcttgtgata acagtgttaa atatgtgtgc     8040

ataaagtctt aaatgaaaag atgtggaaaa taactaaaat agtgttgtca ttgtgggaat     8100

ttggttaaat attttgtctc aaattcctta aataatcttt ggtgttttgg taataaattt     8160

tatgtatgta ttttccatta caaatataat acatactcat acaaaacttt ggaaattcag     8220

taaagaaaat tcacacatat tcccaacacc caacaacaat taactgttaa catcttgatc     8280

tgtgcactag tctgtgatta ttagggtgtt agtgataagt atgcataaat gtcaaagatg     8340

ggaagaaaga tgaaaaacaa gaaatagttg tgtggttgtt gtgggattat ggttattttg     8400

tttcggtttc cttgaaaggt catcattcta gtgttttggt agtccacctt tactacatat     8460

atttccatta tatatgaaat gtgttcatta tagaaacttt gaagttacag aaatgtagaa     8520

gagaaactca cccatgtttt caccatccaa agagtgtggt taacatcttg atatattttc     8580

ttcatcttgt ttctgtgcac aggtttttgg tttgttaata tggttgtggt cattctatct     8640

gtaatagtgt caacaataaa aataaagtta aaaataaata ttt                       8683


<210> 2946
<211> 589
<212> DNA
<213> Homo sapiens

<400> 2946
agtctggtcc tcactgctgt ggattgcctt tactaaaata gagatctatg cagaaataca       60

gttgcatagc ttttcacata aggctcttca tgatatggcc tttgcctgct tttatggcat      120

ggtccatcta ctctgcccca tgtgcctctc cttgctgcca tacagaactc tatcagggga      180

acctgccccc aatatttcaa ggcaagaaat aatggcggca gctacggggg atcctggact      240

ctctaaactg cagtttgccc cttttagtag tgccttggat gttgggtttt ggcatgagtt      300

gacccagaag aagctgaacg agtatcggct ggatgaagct cccaaggaca ttaagggtta      360

ttactacaat ggtgactctg ctgggctgcc agctcgctta acattggagt tcagtgcttt      420

tgacatgagt gctcccaccc cagcccgttg ctgcccagct attggaacac tgtataacac      480

caacacactc gagtctttca agactgcaga taagaagctc cttttggaac aagcagcaaa      540

tgagatatgg gaatccataa aatcaggcac tgctcttgaa aaccctgta                  589


<210> 2947
<211> 1720
<212> DNA
<213> Homo sapiens

<400> 2947
agcacactgg aaggagtcat ggcggatggt caggtggcgg aactgctgct ccggcggctg       60

gaggcgtctg atggcggcct ggacagcgcc gagttggcgg ctgagctggg catggagcac      120

caggcggtgg tgggcgccgt gaagagcctt caggcgctgg gcgaggtcat cgaggctgaa      180

cttcggtcca ccaagcactg ggagcttact gcggagggcg aggagattgc ccgggagggc      240

agccatgagg cccgtgtgtt tcgaagcatt cccccagagg gcctggccca gagcgagctt      300

atgcgactgc ccagtggcaa agtgggcttc agcaaggcca tgtccaacaa gtggattcgg      360

gtggacaaga gtgcggctga cgggccccgg gtgttccgag tggtggacag catggaggat      420

gaggtgcagc ggcggctcca gctggtccgg gggggacagg ctgagaagct gggggagaag      480

gagaggagcg agctgaggaa gaggaagctg ttggctgaag ttggctcttg gcgggaccgg      540

cccttcaagc cctacaactt cttggcccac ggtgtcctcc ccgacagcgg ccaccttcac      600

ccgctgctca aggtccgctc ccagttccga cagatcttcc tggagatggg gttcaccgag      660

atgccgactg ataacttcat tgagagctcc ttctggaact ttgacgccct cttccagccc      720

cagcagcacc cagcccgtga ccagcacgac accttcttcc ttcgagatcc agcggaggcc      780

ctgcagctcc caatggacta tgtccagcgg gtcaagcgga cccactctca gggcggctac      840

ggctcacagg ggtacaagta taactggaag ctggacgagg cccggaaaaa cctactgcga      900

acccacacca catcagccag cgcccgtgcg ctctaccgcc ttgcccagaa gaagcccttc      960

actccggtca agtacttctc catcgaccgc gtattccgga atgagaccct ggacgccacg     1020

cacctggctg agttccacca gatcgagggc gtggtggcgg atcatggtct caccttgggc     1080

cacctcatgg gcgttctgcg ggagttcttc accaagctgg gtatcacgca actccgcttc     1140

aagccagcct acaacccata cacagagccc agcatggagg tgttcagcta ccaccaaggc     1200

ctgaagaagt gggtggaggt cggaaactcg ggggtcttcc gtccagagat gctgctgccc     1260

atggggcttc ccgagaacgt gtcggtcatt gcctggggcc tctccctgga gcgcccaacg     1320

atgatcaaat atggcatcaa caatatccgg gagctggtgg gccacaaggt gaacctgcag     1380

atggtgtatg acagtcccct gtgccgcctg gatgccgagc cgaggccccc tcccacacag     1440

gaggctgcgt gacatgggcc actctaggac aggtcatcct ccccgagtcc ctgctgctgc     1500

gctcctttgc atccctggcc agtgaccttg tatttatgag gcctctgtga ggccagcccc     1560

caccttcctc tttcccacct gtcccaggac cagaatccca gggacagagg actgggtagc     1620

aggttccttc tgttgtcctg tgtggtgtgt ctactgtgag ggtgggccct gaggagacct     1680

gtgggccacc tattgtctaa taaagtgggc agttgccccc                           1720


<210> 2948
<211> 3564
<212> DNA
<213> Homo sapiens

<400> 2948
gtcgcggcct tcgccgccgc caacggggct gtccctgtag ctcccgatgg agtttgaggt       60

cgtgaaacct ccgccgagct ctgccccggc gagacgaggc gcctccgtcg ccaagccgcg      120

ccgtcgcggg gctcccggga gcggccctta gcgaccccgc ccgggccccc tcagcttaca      180

aaacactaca cagcaaaata atgatctgct agactgctaa cccgagcatc cagcttccac      240

aatgcctgtg caggcagctc aatggacaga atttctgtcc tgtccaatct gctataatga      300

atttgatgag aatgtgcaca aacccatcag tttaggttgt tcacacactg tttgcaagac      360

ctgcttgaat aaacttcatc gaaaagcttg tccttttgac cagactgcca tcaacacaga      420

tattgatgta cttcctgtca acttcgcact tctccagtta gttggagccc aggtaccaga      480

tcatcagtca attaagttaa gtaatctagg tgagaataaa cactatgagg ttgcaaagaa      540

atgcgttgag gatttggcac tctacttaaa accactaagt ggaggtaaag gtgtagctag      600

cttgaaccag agtgcactga gccgtccaat gcaaaggaaa ctggtgacac ttgtaaactg      660

tcaactggtg gaggaagaag gtcgtgtaag agccatgcga gcagctcgtt cccttggaga      720

aagaactgta acagaactga tattacagca ccagaaccct cagcagttgt ctgccaatct      780

atgggccgct gtcagggctc gaggatgcca gtttttaggg ccagctatgc aagaagaggc      840

cttgaagctg gtgttactgg cattagaaga tggttctgcc ctctcaagga aagttctggt      900

actttttgtt gtgcagagac tagaaccaag atttcctcag gcatcaaaaa caagtattgg      960

tcatgttgtg caactactgt atcgagcttc ttgttttaag gttaccaaaa gagatgaaga     1020

ctcttcccta atgcagctga aggaggaatt tcggagttat gaagcattac gcagagaaca     1080

tgatgcccaa attgttcata ttgccatgga agcaggactc cgtatttcac ctgaacagtg     1140

gtcctctctt ttgtatggtg atttggctca taaatcacac atgcagtcta tcattgataa     1200

gctacagtct ccagagtcat ttgcaaagag tgtccaggaa ttgacaattg ttttgcaacg     1260

aacaggtgac ccagctaact taaatagact gaggcctcat ttagagcttc ttgcaaacat     1320

agaccctaat ccagacgctg tttcaccaac ttgggagcag ctggaaaatg caatggtagc     1380

tgttaaaaca gtagttcatg gccttgtgga cttcatacaa aattatagta gaaaaggcca     1440

tgagacccct cagcctcagc caaacagcaa atacaagact agcatgtgcc gagatttgcg     1500

acagcaaggg ggttgtccac gaggaacaaa ttgtacattt gcccattctc aggaagagct     1560

tgaaaagtat cgattaagga acaaaaagat caatgccact gtaagaacgt ttcctcttct     1620

aaataaagtt ggtgtaaaca acactgtcac aaccacagcc ggaaatgtca tttctgtcat     1680

aggaagtact gaaacaacag ggaaaattgt tccaagtaca aacggaattt caaatgcaga     1740

aaacagtgtt tcccagctaa tctcacgtag tactgacagt accttaagag ctctggagac     1800

cgtgaagaaa gtgggaaagg ttggcgctaa tggtcagaat gctgctgggc cctctgcaga     1860

ttctgtaact gaaaataaaa ttggttctcc acccaagact cctgtaagta atgtagcagc     1920

tacctcagct gggccctcta atgttggaac agagctgaat tctgtgcctc aaaaatccag     1980

cccatttcta actagagtac cagtatatcc tccgcattct gaaaacattc agtattttca     2040

agatccaagg actcagatac cctttgaagt cccacagtac ccacagacag gatactatcc     2100

accacctcca acggtaccag ctggtgtggc tccctgtgtt cctcgctttg tgaggtccaa     2160

taacgttcca gagtcctccc tcccacctgc ttccatgcca tatgccgatc attacagtac     2220

attttcccct cgagatcgaa tgaattcttc tccttaccag cctcctcctc cgcagccgta     2280

tggaccagtt cctccagtac cttctggaat gtatgctcct gtgtacgaca gcaggcgcat     2340

ctggcgccca cctatgtacc aacgagatga cattattaga agcaattctt tacctccaat     2400

ggatgtgatg cactcatctg tctatcagac atctttgcgg gaaagatata actcattaga     2460

tggatattat tcggtggctt gtcagccacc aagtgagcca aggacaactg tgcctttacc     2520

aagggaacct tgtggtcatt tgaagaccag ttgcgaggag cagataagaa gaaagccaga     2580

tcagtgggca cagtaccaca ctcagaaagc acctcttgtc tcttcaactc ttcctgtggc     2640

aacacagtca ccaacaccac cttctcctct gttcagtgta gactttcgtg cggatttctc     2700

agagagtgtg agtggtacaa aatttgaaga agatcatctt tcccattatt ctccctggtc     2760

ttgtggcacc ataggctcct gtataaatgc cattgattca gagcccaaag atgtcattgc     2820

taattcaaat gctgtgttaa tggacctgga cagtggtgat gttaagagaa gagtacattt     2880

atttgaaacc cagagaagga caaaagaaga agatccaata attcccttta gtgatggacc     2940

catcatctca aaatggggtg cgatttccag atcttcccgt acaggttacc ataccacaga     3000

tcctgtccag gccactgctt cccaaggaag tgcgactaag cccatcagtg tatcagatta     3060

tgtcccttat gtcaatgctg ttgattcaag gtggagttca tatggcaacg aggccacatc     3120

atcagcacac tatgttgaaa gggacagatt cattgttact gatttatctg gtcatagaaa     3180

gcattccagt actggggacc ttttgagcct tgaacttcag caggccaaga gcaactcatt     3240

acttcttcag agagaggcca atgctttggc catgcaacag aagtggaatt ccctggatga     3300

aggccgtcac cttaccttaa accttttaag caaggaaatt gaactaagaa atggagaggt     3360

aaagaaactg aacctttcgg cttcatgctt aatgtatttg ttttctgctg ctgcatcttg     3420

gttataccat tactgagtgc attttggtgt gcctatctct gatggatgat tgattgcttt     3480

taaaacttat aacagaaata aaattgtaat cccagatttc ttaaataatt ctttaactag     3540

atcatcggga tttttgtttt tttg                                            3564


<210> 2949
<211> 2031
<212> DNA
<213> Homo sapiens

<400> 2949
ggcggggggt tcgcccagcg tcgtggacta tttccctagc gaggacttct accgctgcgg       60

ctactgcaag aacgagtcgg gcagccgctc caatggcatg tgggcacatt ccatgacagt      120

acaggattat caggatctca tagaccgagg atggcgaaga agtggaaaat atgtgtacaa      180

acctgtcatg aatcaaacat gttgtcctca gtacacaata aggtgccgac ctttacaatt      240

tcagccttca aaatctcaca agaaggtttt gaaaaaaatg ttgaaatttc tagctaaagg      300

ggaggttccc aaaggaagtt gtgaggatga gcccatggat tccacaatgg atgatgctgt      360

tgcgggtgac tttgcattga taaataaact ggatatacag tgtgatctta aaacactcag      420

tgatgacatc aaagagagtt tagagagtga aggaaaaaat tcaaagaaag aagaacctca      480

ggaattactt cagtcacaag atttcgtagg agagaagttg ggctctggtg aaccgtcaca      540

ttcagttaaa gttcacacag ttcctaagcc aggcaaaggg gctgatttga gtaagcctcc      600

atgtcgaaaa gcaaaggaaa tccggaaaga aaggaaaagg ttaaaactaa tgcagcagaa      660

cccagctgga gaacttgagg gtttccaggc tcaaggtcac ccaccatctt tgtttccacc      720

aaaggctaaa tccaaccagc caaaatcact cgaagattta atttttgagt ctttaccaga      780

gaatgcatca cacaagttag aggtgagggt ggtgagatca tctccaccaa gttcgcagtt      840

caaagccaca cttctggagt cttaccaggt ctataaacgt taccagatgg ttattcacaa      900

gaacccacct gatacgccaa ccgaaagcca gttcacaaga ttcctttgca gttcaccctt      960

ggaggcagag actcccccta atgggccaga ttgtggctat ggctcctttc accagcagta     1020

ctggcttgac ggaaagatca ttgctgtggg ggtgattgac atcctcccaa actgtgtatc     1080

atctgtgtat ttgtactacg atcctgatta ttcgtttttg tctttgggcg tctactctgc     1140

actacgagaa attgctttta ctaggcagct tcatgagaaa acttctcaac tcagctatta     1200

ttatatgggt ttctacattc attcatgtcc caagatgaaa tataagggtc agtatagacc     1260

ttctgatttg ctgtgccctg agacatatgt ttgggtaccc attgagcaat gcctgccttc     1320

acttgaaaac tccaagtact gccgtttcaa ccaggaccca gaagcagtgg atgaggatcg     1380

cagtacggaa cctgaccgat tgcaggtgtt tcacaagaga gccatcatgc cttacggtgt     1440

ttataagaaa cagcagaaag acccaagtga ggaggctgct gttctgcagt acgccagcct     1500

ggtggggcag aagtgctccg agcggatgct gctgttcaga aactgacctg ttcacctctg     1560

ccgggaagtt cctgtgttgt gctgatgatt tgtgccagga tacatattca gtacctgtgg     1620

ggaaataact gtcaccaccc acaaattaga cattttttat tttgactatc tatggctttt     1680

aaaaaatatt ttgtggcaat gtatctgtga gaatctcata gttaatataa agattttaaa     1740

actgcattat gacctagccc ccataattgg gatttatcat tttggaggat tctttctaga     1800

gcaagatacg ctcaaattct cctgtttgta ttttgtaaaa tgaagaagtg aatctaagta     1860

acttaatcac agttgtgcat tttttttggt tctgttagag aaattaaaac agactgtttc     1920

ctcaggccca ttttaaactg aacttatgct aggaaacctt aagtatgggg aaggtagaaa     1980

gttcatttca tcacttagaa aatatgtctt ctcaagaaca aaactgtgct g              2031


<210> 2950
<211> 572
<212> DNA
<213> Homo sapiens

<400> 2950
tgaaccacca gccagctgca tttgttgtcc tggaagtcat tgccaactct gccagtcaca       60

ctggggtccc cagagaagtc aagagcctct gggatattgg gcacctgaag agctgcagcc      120

ccagctctgc cctcagggag tttctgtttt ggtggggaga aggccactga aaccagggag      180

tgcggttgtg tttgcaaact tccaattgaa gacactgagc tgaaccattc cgcccgcccg      240

cccgcccgag ggcactccag atctgccgga ggcgctgggc aatgaccccg ggactccagg      300

ccagaggggt ctgaagctgt ttgggaaagc agcgggactc cttgggaaga tggccatggc      360

cccaagccct tccctggtgc aggtgtacac cagccccgcg gctgtggccg tgtgggaatg      420

gcaggacggg ctgggcacct ggcaccccta cagtgccacc gtctgcagct tcatcgagca      480

gcagtttgtc cagcagaagg gccaacgttt tgggcttggg agcctggccc acagcatccc      540

cttgggccag gcagacccct cgctggcccc tt                                    572


<210> 2951
<211> 654
<212> DNA
<213> Homo sapiens

<400> 2951
caaatttgcg cgggttggag cctggcgtag tcatggccgc cttccgcgac atagaggagg       60

tgagccaggg gctgctcagc ctgctgggcg ccaaccgcgc ggaggcgcag cagcgacggc      120

tgctggggcg ccacgagcag gtggtggagc ggctgctgga aacgcaagac ggtgccgaga      180

agcagctgcg agagatcctc accatggaga aggaagtggc ccagagcctt ctcaatgcga      240

aggagcaggt gcaccaggga ggcgtggagc tgcagcagct ggaagctggg cttcaggagg      300

ctggggagga ggacacccgt ctgaaggcca gcctccttca gctcaccaga gagctggaag      360

agctcaagga gattgaggcg gatctggagc gacaggagaa ggaggtcgac gaggacacga      420

cagtcacaat cccctcggcc gtgtacgtgg ctcaacttta ccaccaagtt agtaaaattg      480

agtgggatta tgagtgtgag ccagggatgg tcaaaggcat ccatcatggc cccagtgtgg      540

cccagcccat ccacctggac agcacccagc tctccaggaa attcatcagc gactacctct      600

ggagtctggt ggacaccgag tggtagccag gagcctcgtg gctgcgtctt gcac            654


<210> 2952
<211> 2909
<212> DNA
<213> Homo sapiens

<400> 2952
aattccggag gcggcattcg gtggtcagag gcctgtgcgg ctgcaggtag agtgtcttag       60

gaacctagga aataactcgg aacctgtaac gtcccactgg tttggacata ttcctctcct      120

gatctggcct catctgttcc agggaggtgg gattgaaaca tatgcagtaa tgtcacctca      180

aaagagagtt aagaacgtcc aggcacaaaa caggacttca caaggtagta gtagttttca      240

gaccacgctt tcagcctgga aagtaaaaca ggatccaagc aactcgaaga acatctcaaa      300

acatggacaa aacaatccag tgggagatta tgaacatgct gatgatcaag ctgaagaaga      360

tgctttgcaa atggcagtgg gatattttga gaaaggtccc attaaagctt cacagaataa      420

agataaaacc ttggaaaaac acttgaaaac tgtggaaaat gtggcttgga agaatgggtt      480

agcttcagaa gaaattgata ttctattaaa tattgcactc agtggcaaat ttggaaatgc      540

tgtaaacaca cggatattga agtgcatgat cccagcaaca gtaatatcag aagattctgt      600

ggttaaggca gtctcctggc tttgtgttgg caagtgttct ggtagcacca aggtactttt      660

ttatcgttgg ctggttgcaa tgtttgactt cattgatcgt aaggagcaaa ttaacttgct      720

ctatggcttc ttttttgctt cattgcaaga tgatgcactg tgcccttatg tttgccattt      780

gttatattta cttaccaaaa aagagaatgt caaaccattt cgtgtgagaa aactgcttga      840

tcttcaggcc aaaatgggaa tgcagcctca tctccaggct ttgttgtcac tgtataagtt      900

ctttgctcct gctctgattt cagtatcttt gcctgtaagg aagaagatat attttaagaa      960

ttcagagaat ctatggaaga cggctctgct tgccgtgaag caaagaaacc ggggaccttc     1020

tccagaacct ctgaagttga tgttaggtcc agctaatgtt cgtcctctaa aaagaaagtg     1080

gaattctctc tcagttatac cagtgctcaa ttccagtagc tacactaaag aatgtggaaa     1140

aaaagagatg agtctttctg attgtctgaa tagaagtgga tcatttccac tagaacaact     1200

tcaaagcttc ccccaacttt tacagaacat ccattgctta gagctgcctt ctcagatggg     1260

ctcagtgcta aacaactctc tgctgcttca ctacattaac tgtgtcagag atgagccagt     1320

cttgctgagg ttttattact ggttgagtca aacattacaa gaagaatgta tttggtacaa     1380

ggtgaataat tatgaacatg gaaaagaatt taccaacttc ctggatacca tcatcagggc     1440

agagtgcttc ttacaagagg ggttttattc ctgtgaagca ttcctgtata agagccttcc     1500

tctctgggat ggcctttgtt gtcggtcaca gttccttcag cttgtgagct ggattccttt     1560

tagtagcttc tctgaggtga aaccacttct ttttgaccat ctagcgcagc tcttctttac     1620

atcaaccatt tatttcaagt gtagtgtgct tcagagtctg aaagagctat tgcagaattg     1680

gctgttgtgg ctttctatgg acattcacat gaaacctgtt acaaacagtc ctctagagac     1740

aactttgggt ggatccatga actctgtgtc taaactgatc cactatgtag ggtggctatc     1800

cactactgca atgcgcttgg agagcaacaa tactttcttg ctgcacttta ttttggattt     1860

ctatgagaag gtgtgtgaca tatatataaa ttataacctt ccattagtgg tattgtttcc     1920

tcctgggatc ttctattctg cactcctcag cctggatacc agcatcctga accagctgtg     1980

ttttattatg cacagatatc gtaaaaattt gactgccgca aagaaaaatg agttggtaca     2040

aaagacaaaa tcagagttca atttcagcag caagacttat caagaattta atcactattt     2100

gacatcaatg gttggttgcc tgtggacgtc caaacccttt gggaaaggaa tatatattga     2160

ccctgaaatc ctagaaaaaa ctggagtggc tgaatataaa aacagtttaa atgtagtcca     2220

tcatccttct ttcttgagtt acgctgtttc ctttttgcta caggaaagcc cagaagaaag     2280

gacagtaaat gtgagctcta ttcggggaaa gaaatggagc tggtatttgg actatttatt     2340

ttcacagggg ttacaaggct tgaaactttt tataagaagt agtgttcatc attcttccat     2400

tcccagagca gagggcataa actgcaacaa tcaatattaa atgaatgttg acataaactg     2460

aacacactgg actaaactca ctcctcattg ctagagcaaa gtggctcatc ttgagttccc     2520

attttcattt cactgacaga ctgccatcct caaggagtac tcagactggc cttctgttca     2580

tggcttagga gagccttggt gtgcctaact gatttttcaa aatttagatt tttttagcct     2640

accagtgaaa aatgacccct tcatcatcag gctctgcgtt ctaccaaatt gtatgtaaaa     2700

agacacatct gttttgtggt aggatttttt cacatttttg ggtactatga gctgcattga     2760

tggaagacag caggcaatat gtggtgacag ttaactcaca gacataaaca tgcaaaatac     2820

tttgctgtct ctggggatat tgccattttt cttactgtga gcaacagcac caacaccaag     2880

ttaacaggat gcaacatgtg tatgactct                                       2909


<210> 2953
<211> 2594
<212> DNA
<213> Homo sapiens

<400> 2953
gcccagggat cagtgtcttt caatgatgtg actgtggact tcactcagga ggagtggcag       60

cacctggatc atgctcagaa gactctatat atggatgtga tgttggaaaa ctattgccac      120

ctcatctctg tggggtgtca catgaccaaa cctgatgtga tcctcaagtt ggaacgagga      180

gaagagccat ggacatcatt tgcaggtcat acctgcttgg aagaaaactg gaaagctgaa      240

gactttttag tgaaattcaa ggaacaccaa gagaagtatt ctagatcagt tgtaagcatc      300

aaccacaaaa aactggtgaa ggagaagagt aaaatatatg aaaagacatt tactctaggc      360

aaaaaccctg tgaattcaaa aaatctacct cctgaatatg atactcatgg aaggattttg      420

aaaaatgttt cagaattaat catcagtaat ctaaatcctg caagaaagag acttagtgag      480

tataatggat atgggaaatc actcctgagt actaaacaag agactactca tcctgaagtc      540

aaatcccata atcaaagtgc cagagctttc agtcataatg aagttcttat gcagtatcag      600

aaaacggaaa ctccagcaca gtcatttgga tataatgact gtgagaaatc attccttcaa      660

aggggaggcc tgattacaca tagtagacct tacaaaggag aaaacccatc tgtatataat      720

aaaaaaagaa gagcaaccaa tattgaaaaa aaacatacat gcaatgaatg tgggaaatct      780

ttctgcagga aatcagtatt gattctgcat cagggaattc actcagaaga aaaaccctat      840

caatgtcatc aatgtggaaa tgcatttaga aggaaatcat atctcattga tcatcagaga      900

actcacacag gagagaaacc ctttgtttgc aatgaatgtg gtaagtcctt ccgcctcaag      960

acagccctca ctgatcatca gagaacacac acaggggaga aatcgtatga atgtctgcaa     1020

tgtaggaatg ccttcagatt gaagtcacac ctcattcgtc atcagagaac tcacacggga     1080

gagaaaccat atgagtgtaa tgactgtggg aagtccttcc gccagaagac aacactctct     1140

ctacatcaga gaatccatac aggtgagaaa ccctacattt gtaaagaatg tgggaagtcc     1200

tttcaccaga aggcaaatct tactgtacat cagagaactc atacagggga aaagccctat     1260

atttgtaatg aatgtgggaa atccttctcc cagaagacaa cccttgctct tcatgagaaa     1320

actcataatg aggagaaacc ctatatttgt agtgaatgtg gaaagtcctt ccgccagaag     1380

acaacccttg tagcacatca gagaacacat acaggggaga aatcttatga atgtcctcac     1440

tgtgggaagg cctttagaat gaagtcatac ctcattgatc atcaccgaac tcacacagga     1500

gagaaaccat atgaatgtaa tgaatgtggt aaatcattca gtcaaaagac aaatctcaat     1560

ctacatcaga gaattcatac aggggagaaa ccctatgttt gtaatgaatg tgggaagtcc     1620

tttcgccaga aagcaaccct cactgtacat cagaaaatac ataccggcca gaaatcctat     1680

gaatgtcctc agtgtgggaa agcctttagc aggaagtcat atctcattca tcatcaaaga     1740

actcatacgg gagagaaacc atataaatgt agtgaatgtg gaaagtgctt ccgccagaag     1800

acaaatctta ttgtacatca gagaactcac acaggtgaga aaccctatgt ttgtaatgag     1860

tgtggtaagt ctttcagtta taagagaaac ctcattgtcc atcaaagaac tcacaaggga     1920

gaaaacattg aaatgcaata aatgatgtgg tttcttatat gaattcttta caagctgttg     1980

taaacattta gttttaaaaa gaaaagcatg ctgaaacatg ttaatgtaat tttaaatcac     2040

aagtctaata attattaaag taccatacgg aataactgtc tactgtttac tagcatataa     2100

aataagtatg atcattatta ttgaactcta tcagctatga agctaaattt taaagtcaac     2160

tgctcttcct actgactcaa atagtttatt ttttaaaaat acttatataa tacatgcaga     2220

gacaagatac acaatgatta taagtattaa tctccataag agaaaatatt tatgaactat     2280

atttctcatt gcactctgta ataaaaagca gttagttgtt acttacctaa gagttaccac     2340

ttccgtagcc tataacatca aaacgtagtt tttgcatgtt ttcaatttta taaatatata     2400

ttttatcaga catcatgaat tattttgtgt cttgcttatt tcactcaatt ttttaagatc     2460

tgtacattat tgcatgtggc agtagtgtat tttcattttg catactattc cattttaaga     2520

atatattgct gtttatccta ttgatggata tttgtatttt ttatactttt gtgtaataat     2580

aaaaatactg ctgt                                                       2594


<210> 2954
<211> 1899
<212> DNA
<213> Homo sapiens

<400> 2954
aaaaagactt tttttagaaa aaaatttcct cttgagccat catgcacatc tgactgcagc       60

cccagcgagc ccttccttcc ttgtctgact gctcttcttc tcgatttctt cttgttctgc      120

cttctcggtt tgcagccctg acccccgctg tgtgtctggc ccttggtgac tgtccgtgtt      180

tctgttcctg tcattgtaac tgtgactttt ctctctgtct gccccccctt cctactggtt      240

catgcttctc ccccattccc accctctctg cccggcctcc cgctcccgcc ctttctcctc      300

atgcacccgg cctcgtctct gtagtctctg cacttgtctc ccattaaggt cccatccatg      360

ggggggcgga agcgggagcg caaggctgcc gtcgaggagg acacctccct gtcggagagt      420

gaggggcccc gccagcccga tggggatgag gaggagagca cagccctcag catcaacgag      480

gagatgcagc gcatgctcaa ccagctgagg gagtatgatt ttgaggacga ctgtgacagc      540

ctgacttggg aggagactga ggagaccctg ctgctttggg aggatttctc aggctatgcc      600

atggcagctg cagaggccca gggagagcag gaagatagcc tggagaaggt gattaaagat      660

acggagtccc tgttcaaaac ccgggagaag gagtatcagg agaccattga ccagatagag      720

ctggagttgg ccacggccaa gaacgacatg aaccggcacc tgcacgagta catggagatg      780

tgcagcatga agcgcggcct ggacgtgcag atggagacct gccgccggct catcacccag      840

tctggagacc gaaagtctcc tgctttcact gcggtcccgc ttagcgaccc gccgccgcgc      900

caagcgaggc tgaggactcc gatcgcgatg tctcatctga cagctccatg agatagagac      960

ctgcctcccc cttgcacccg aggccctcgc agcagggagc tcagcgaggc agagggtggg     1020

gctgcacaga ggggaacatc agctgcagct ctgcaccagg ccggtccctg gggactgggg     1080

cgctcctccc tcaggctttc tccctcagtc ttggcttctc cagggctctg gggtgtctgg     1140

agctaggctt ggccctacca ttctggggcc atttccacca cagttggggc tctcctgcct     1200

tcacgcgtgg gtgtctgcta cttccccatc tttaaaatgc tgccagagcg attgcggccc     1260

ctcaccttgt ccacgtatca ggaatgtgaa tgtgggacct ttcctccatc cctgttgtcc     1320

ggagccagct cactgtcttc cacactggtg ctaactggcc caggcactgg agtggaatag     1380

aatgcagctg gaggctacgc atggcctctg cagcacacgc agctggagag ggcttctgtc     1440

cctgtcagcg gcagagggcg ttggggctgg ccggggcacc ttgtccctgc tatggtccac     1500

gtgctcacgc tgtccacctg ccaggtggag tgtatgtggc tgtggccctc cctcgtggag     1560

gtgccgtgct ttaaagaggc cttagtgccc gggatgggca cagtgttttg aagggaggtg     1620

ggagctcttg ctctcctggt cactgcagaa tgacagagaa ggtgaagctc catgcatgtg     1680

tgcgcgggtg tatgtgcgct cagggtctct gtttaagtat cagctaaaga tgtgcttcct     1740

ccgtgtctgt catacactga gaccaacagg ctacagtgtc cctgattctt ggaaaagcct     1800

ggagaagctg gggagatgcg gttcacaatg cctcggtata ggaggctgtg ttgagctgac     1860

attcaaatgg attctttaat aataatgaaa ctggcgagt                            1899


<210> 2955
<211> 859
<212> DNA
<213> Homo sapiens

<400> 2955
ctctggctgc cttctcctga gagtcggagc cacagccaga gccctgccca ggccgagccg       60

gagctgcagc ccgagcgcgg tggtgccctc agccccgtcc tcttgtcctc ctcagcctcg      120

gtgccttgga atttgtgtcg ctgagtcagc aagcctttca gatttgcccg gtttttgttg      180

tttgtggttt gtatcaagat gggaactcaa acaagtcatt cctcctaagg agctggtgtc      240

ttcatccaga agggacagtt tgtgccagct ctccagagag aaaagaaact tccaattgaa      300

gacactgagc tgaaccattc cgcccgcccg cccgcccgag ggcactccag atctgccgga      360

ggcgctgggc aatgaccccg ggactccagg ccagaggggt ctgaagctgt ttgggaaagc      420

agcgggactc cttgggaaga tggccatggc cccaagccct tccctggtgc aggtgtacac      480

cagccccgcg gctgtggccg tgtgggaatg gcaggacggg ctgggcacct ggcaccccta      540

cagtgccacc gtctgcagct tcatcgagca gcagtttgtc cagcagaagg gccaacgttt      600

tgggcttggg agcctggccc acagcatccc cttgggccag gcagacccct cgctggcccc      660

ttacattatt gacctcccca gctggaccca gttccgccag gacaccggca ccatgcgggc      720

tgtgcggaga cacctgttcc cccagcactc agcccctggc cgaggtgtcg tctgggagtg      780

gctgagcgac gatggctcct ggactgccta tgaagccagc gtctgtgact atctggagca      840

gcaggtggcc aggggcaac                                                   859


<210> 2956
<211> 4529
<212> DNA
<213> Homo sapiens

<400> 2956
gtttgcatgc atccccacaa tgttctgtct gatgtggtga actataccct gtggttaatg       60

gagtgttctc atgcttcagg atgctgccat gctaccatgt ttttttcaat ttgcttctca      120

tttcgggccg tcttggagct ctttgaccgc tatgatggtc ttcgtcgtct ggtgaacttg      180

atcagtactt tggagattct aaatttggaa gatcagggtg cacttctgag tgatgatgaa      240

atatttgcta gccgccaaac tgggaaacat acctgcatgg ccttgcgcaa atactttgag      300

gctcacctgg ccattaaatt ggaacaagtg aagcagtcac ttcagaggac tgagggtggc      360

attcttgtcc acccacaacc cccgtacaag gcatgctcat atactcatga acagattgtg      420

gaaatgatgg aatttttgat agaatatggc ccagcgcagc tatattggga accagctgaa      480

gttttcctca aactttcttg tgtgcaactc ttgttgcagc ttatttctat tgcctgcaat      540

tggaagacct attatgcaag gaatgacact gtgcgctttg ctttggatgt cctggctatt      600

cttactgtgg tgccaaaaat ccagctccag ttggcagaat cagtggacgt gttggatgag      660

gctggatcta cagtctctac tgtaggtatc agcattattt tgggagtggc tgagggtgag      720

ttcttcatcc atgatgctga aattcagaag tcagcacttc agattatcat caattgtgtg      780

tgtggcccag ataaccgaat atccagtatt ggtaaattta tctctggtac tcctcggaga      840

aagctgcctc agaaccctaa aagcagtgag cacaccctgg ccaagatgtg gaatgtggtt      900

cagtccaaca acggcatcaa ggtgctcctg tccttactgt ccattaagat gcccatcaca      960

gatgcagacc aaatccgggc cctggcctgc aaagccctag tgggcctgtc tcgcagtagc     1020

actgtccggc agatcatcag taaactgccc cttttcagca gctgccagat ccagcagctg     1080

atgaaggagc ctgtgctgca ggacaagcgc agtgaccatg tcaagttctg caagtatgct     1140

gctgaactca ttgaacgggt gtcaggaaaa ccacttctca ttggcactga tgtttcccta     1200

gcacgactgc agaaagcaga tgttgttgcc cagtcaagga tctccttccc tgagaaagag     1260

ctgcttttgt tgatacgaaa ccatcttatt tctaaagggc ttggagaaac agcaaccgtg     1320

ctgacaaaag aggctgacct gcccatgact gctgcctccc attcttctgc ctttacccca     1380

gtcactgctg ctgcttctcc tgtctctcta ccccgaaccc ctcgtatcgc taatggcatt     1440

gcaactcgtc tgggcagcca tgctgctgtg ggtgcctctg cgccttctgc ccctactgct     1500

catcctcagc cacggccccc ccagggtccg ctagctctgc ccggcccatc ttatgcaggc     1560

aactcccctt tgattggtag aatcagtttt atcagagaga ggccatcacc ctgcaatggc     1620

aggaaaatca gagtgttgcg gcagaagtcg gaccatggtg cctacagcca aagcccagcc     1680

ataaaaaaac agctggacag acatcttcct tccccaccta cgctggacag tataatcaca     1740

gagtatctta gagaacaaca tgctcgctgc aagaatccag ttgccacctg cccacctttc     1800

tccctcttta ctcctcacca atgtcctgag ccaaaacaga ggcggcaagc gccaataaac     1860

tttacgtcaa ggctaaaccg cagggcatca tttccaaagt atggaggggt ggatggcgga     1920

tgctttgata ggcaccttat ctttagcaga ttccgtccta tttcagtgtt ccgggaagcc     1980

aatgaagatg agagtggctt cacctgctgt gcattctcag cacgggagcg gttcctgatg     2040

cttggcacct gcacagggca gctgaagctc tataatgtgt ttagtggaca ggaggaggcc     2100

agctataact gtcacaactc agccatcaca catcttgaac cttccaggga tgggtccttg     2160

ctgctgacat ctgctacttg gagccagcct ttgtctgcac tttggggaat gaagtcagta     2220

tttgatatga agcattcctt cacagaagat cactatgttg agttcagtaa gcactcccag     2280

gatcgggtca tcggcacaaa aggagacatt gcccacattt atgatattca gactggcaac     2340

aagctgttga ctctgtttaa cccagatctt gccaacaact acaagaggaa ctgtgccacc     2400

tttaatccta cagatgatct tgtcttaaat gatggcgtcc tctgggatgt ccgctctgca     2460

caggccatcc acaagtttga caagttcaat atgaacatca gtggtgtttt ccatccaaat     2520

ggactggagg tgatcattaa tactgagatt tgggaccttc gaacttttca tcttttgcat     2580

actgttcccg ctctggatca gtgtcgcgtg gtgttcaatc acacgggaac agtgatgtat     2640

ggagctatgt tgcaggcaga tgatgaagat gacttaatgg aagagaggat gaaaagcccc     2700

tttgggtcat ccttccgaac atttaatgca actgactaca aacctatagc aaccattgat     2760

gtgaaacgga acatctttga cctgtgtaca gacaccaaag actgctatct tgctgtcatt     2820

gagaatcaag gcagcatgga tgccctgaac atggacacag tatgcaggct gtatgaagtg     2880

ggcaggcagc gtctggcaga ggatgaggat gaagaggagg accaggaaga ggaagaacag     2940

gaggaagaag atgatgatga agatgatgat gacaccgatg atttagatga gcttgacact     3000

gaccagttgc tggaggcgga gttggaggag gacgacaata atgagaacgc aggggaagat     3060

ggggacaatg acttctctcc ctctgatgag gagctagcaa accttctaga ggagggagag     3120

gacggggagg atgaagactc tgatgcagat gaggaggtgg aactgatcct gggggacact     3180

gacagctctg acaactctga tttggaagat gacatcatct tatctctgaa tgagtgagga     3240

gccatcactg cttggaagag attcttggca gagagaagag gggacaaatt tggttgtgaa     3300

gtaaacaaga aacacaagac ggctaaaact ctccaggggc aggtaaagcc ctgctgggct     3360

cagaagcact atagaatttg ctgtacacac tgaagtgggt ctgtgtcaca caggtatttc     3420

ttggtcctct ggagagcaga ggactcactc agctctttgc ttcatgcctc gctttaatgg     3480

tagtaaacac ttaaccagtg gaatagtctg actgctggta ctgatggcat cagaagaaaa     3540

caggttaaca atcaagtagt gaaagcacta tattctagtc attaactcaa cggagccagt     3600

ctcaactctg ctgggagcac ccacaggtct ctgtggggga gacagggact ataacaggga     3660

ggcagaattc aggttggctt gacaacacac cttaggaaca tgtgctaagg ggctaaggag     3720

gcatcagctg tcttccttat tctaccaggg ctgaaaatcg gagtcactta ggaggcagca     3780

tgagaacagt ggcacaccac cagtgaggca catgttgcct ttttgtcttt aagcaacacc     3840

ttagacaggg cctgaaccct gggtgggggc actggatgcc tgaagtaagt aagttttctc     3900

agtggggcag tctcataaaa tcaccaggac attgaccacc tgacctcccc taactagtgc     3960

tggccaaggc ctgagagttc acagaacctg ctaggtctta agagccaaag gaaggaagtg     4020

gttgagggcc aggaaagaga aggaatgtca tgccagggtg ttactcctca ccaaaacttg     4080

gcagttcttt ttggggccat gggacacctt tctctgaaga ggggttggat aaggcaaagg     4140

ttgaagtgtc ttctctaggc acgttttcta gcatgtttcc ttttacttgg ttctgtctca     4200

caaagctggg aggtagatga ttcttccggg tcctgagcac ctgcttcatg aaggaagata     4260

ggtagcccag agaagaagtt ttggacttaa caacatacca aggcagctct ggcctgtgac     4320

tcaggcgttt gttggagagc tgcaggaaaa ccactgcagt gtgcctgcaa caggacaaga     4380

cccactcctg tttctggcgg taccagctac cctggaatgg tggcgtgtcc tgctgtaccc     4440

aactgacttg cttaggtacc tggcagctgt gaccacagct caagtaaaaa aacaaaaaca     4500

ggcaaataaa taaacatgct taacatgtc                                       4529


<210> 2957
<211> 793
<212> DNA
<213> Homo sapiens

<400> 2957
gacaacaaga tggcggcgct gcgggacggc tagcggccct gcgtgtactt tcccaagcac       60

caccaggcca aaggtctctc agttcagagc agaaagccgt atacccagag gagcaggcag      120

ataacagaaa cttccagaaa cctctgtgga gacagtggaa gaggcaaaag ggagttcctg      180

acagctggat tctagaagta gaactatgag ctcacctttg gcctccctta gcaagacccg      240

aaaagtgccc ctgccctcgg agcctatgaa tcctgggagg cgaggaatcc gcatctatgg      300

agatgagcgg tgacctaggc atccctgtct gcagaagatg aggtggacat gttgagtgat      360

gggtgtggct cagaagaaaa gatctcagtc ccttcctgct atggcggcat aggtgcccct      420

gtgagtcggc aagtccctgc atcccatgac tcggagctga tggccttcat gacgaggaag      480

ttgtgggacc tggagcagca ggtgaaggcc cagactgatg agatactgtc caaggatcag      540

aagatagcgg ccctagagga cctggtgcag accctccggc cacacccagc cgaggcaacc      600

ctgcagcggc aggaggaact ggagacgatg tgtgtgcagc tgcagcggca ggtcagggag      660

atggagcggt tcctcagtga ctatggcctg cagtgggtgg gcgagcccat ggaccaggag      720

gactcagaga gcaagacagt ctcagagcat ggcgagaggg actggatgac agccaagaag      780

ttctggaagc cag                                                         793


<210> 2958
<211> 2643
<212> DNA
<213> Homo sapiens

<400> 2958
gcctgacgcg gcgttgcgtc ccccgggagc tgcgctaggc gaacggctgc ggcgctttgt       60

gctccagtcg ctcctaacgc tccctggccc ggccggggcc gcgcagttag ggcatctgag      120

gcggggagaa gcggcgggga gacgccggct gccagcatgt cgctgcctcc ggagaaagcc      180

tccgagctga agcagctcat ccaccagcag ctgagcaaga tggatgtcca tggtagaata      240

agagaaatcc ttgctgagac tatacgggaa gaattggcac ctgatcaaca gcatttatca      300

acagaagatt tgatcaaagc ccttagacgt cgaggaatca ttgacgatgt gatgaaagaa      360

cttaattttg ttactgacag tgttgagcaa gaactccctt cctctccaaa acaacctatt      420

tgttttgata gacaatcgac attaaaaaaa agtgatggaa ctagaatggc tgattcaaca      480

acaatgttat caataagtga tccaattcat atggtgctaa tcaaaacaga catatttggt      540

gagacgactt tagtagcatc atattttctg gaatggcgat cggttttggg ctcagaaaat      600

ggagtgacca gtctgactgt ggaacttatg ggtgtaggca cagaatcaaa agtttctgtg      660

ggaattttaa atataaaact tgaaatgtat ccaccactca atcaaacgtt atctcaagaa      720

gtagtgaaca cacagcttgc tttggaacgt cagaaaactg cagagaaaga gcgattattt      780

cttgtatatg ctaagcagtg gtggagagaa tatttgcaaa ttcgaccctc acacaactca      840

cgactggtta agatttttgc acaggatgaa aatgggataa atagaccagt ctgttcctat      900

gttaaaccac ttcgagctgg acggcttctt gatactccaa ggcaagcagc aagatttgtt      960

aatgtccttg gttatgaacg agcccctgtt attggaggag gaggtaaaca ggagcagtgg     1020

tgcactctgc tggcctttct ctgtagaaac aagggtgact gtgaagatca cgctaacctt     1080

ctgtgcagcc ttcttcttgg atatggatta gaagcctttg tttgtgttgg gaccaaggca     1140

aaaggagtac ctcatgcatg ggttatgact tgtggaactg atggggccat cactttttgg     1200

gagagtttaa caggacacag gtacatccat aaacctacca atcctgatga acctccagtt     1260

gctgaacagc ccaaaccact gtacccatat cgaacaattg gttgtgtttt caaccatcag     1320

atgttcctgg gaaattgtca accctctgat gcagtagaaa cctgtgtatt tgatttgaac     1380

gatgaatcca aatggaaacc catgagtgag gaagcaatta aatctgtgtg tgctcctgga     1440

gctacaacat cccttcctcc ctttccacct ctgtgtgcat ccacaattga cgcgtcagta     1500

acaagtaatg aaattgaaat gcagctgagg ctcctggtgt cagaacacag gaaggatctt     1560

ggcctcacta ctgtttggga agaccagctc tcctaccttt tatcaccagc tttggcttct     1620

tatgaatttg agcgtacaac aagtatatca gcaggcaatg aagaatttca agatgccata     1680

agaagggctg tacctgatgg tcacacattt aaagggttcc caatacattt tgtgtataga     1740

aatgcaagac gtgcatttgc cacatgtctt cgatctcctt tctgtgaaga aataatctgt     1800

tgccgtggag accaagtgcg actggcagtt cgtgtccgag tatttactta ccctgaatct     1860

gcatgtgctg tttggatcat gtttgcttgt aaatatcgct cggtattata gggccaatat     1920

ttatataaga tttatacctg tgtttaattg gaattttaca cattgtacat tacttagcta     1980

tttagaggtt tgttatttta aaatcacaat ctggcttgaa tggcatactt caattttgta     2040

tatacttgac tggtaatgtt taaaaaaaat catgcattcc tttaaaaatt aaggctgaaa     2100

aacttgtata aatctccctg gaatttagta taaattaagt gtatattcta ttttaataaa     2160

tgctactttg tttacagtta tcagtagttt aaatattaat ataaaatgca ttcagttttc     2220

tttacacaaa caggtaatca aagagatgtt tgtctaaggg tttgagccct agacaaatca     2280

gtatgatcat tacttttcac aggttaatgg aattatttta tacagattag gagaaattaa     2340

cctcatgaca gatttattta ttgcattggt gaaaataaat gttaatgaat taccactttt     2400

gtggtttatt cgtggtcctt gggatatttg agactgtcca gaaatttatg gttggacctt     2460

gaagcaagag taggaaaaaa ctaataccag aaaagcataa atattaataa cctcatatga     2520

aagtacatga atcatttaga aatatttatc actgtgattt gttgtaaaaa tgaattgggt     2580

attttagaaa aactttatta tacctctttg ttatgatact gataaattgt gatcttgcag     2640

tcg                                                                   2643


<210> 2959
<211> 5339
<212> DNA
<213> Homo sapiens

<400> 2959
acagtccctg gtaaacacaa gtagtattac aagtcgggag ctcttcaagt cttggatgag       60

actgtagagc ggtcttgtgc ggcaatgtgc taccttaaaa taaataaata aataaacccc      120

tgttatgtcc ggagtttgtt tccacccgga gaggaatgga agagcaccag agagcgctta      180

gctttctggt tggatgtttt gggttcatca gacttaactt ctgctagaaa ttgttaccag      240

cctctattag aaaatcccat ggtgtcagaa agtgattttt ctaaagacgt tgcagtgcaa      300

gtgttgcctt tggataaaat agaagagaac aacaagcaaa aagcaaatga catcttcatt      360

tctcagtata caatgggaca gaaagatgct ctaagaacag ttttaaagca aaatgtctca      420

ctttgtctca caggctggag tgatcacagt ggggtgatca caactcactg cagtctctac      480

ctcctcaggc tcatgagatc ctcccacctc agcctcccga gtagctggga ctacagagct      540

caaagcatgc ctgtttttaa ggaagtaaag gtacatctgt tagaagatgc aggcatagag      600

aaggatgctg ttactcagga gactagaatt tcacccagtg gaattgattc agctacaacc      660

gtggctgcag caactgctgc tgccattgca accgcagctc cgttgataaa ggtgcagagt      720

gatttggaag caaaagtcaa ttctgttaca gaattactta gtaaattaca ggagactgat      780

aaacacctgc aacgtgttac agagcagcaa acaagcattc agaggaaaca agagaaatta      840

cattgtcatg atcacgaaaa gcaaatgaat gtgtttatgg agcagcacat aaggcatctt      900

gaaaagttac aacaacaaca aatagatatt cagactcatt ttattagtgc tgcactcaag      960

actagtagtt ttcagcctgt tagtatgccc tcctccagag cagtggaaaa gtattccgta     1020

aaaccagaac accctaatct tggtagctgt aatccatctt tatataacac atttgcttcc     1080

aaacaagcac ctttaaaaga agttgaagat acgagttttg ataaacagaa atctcctttg     1140

gagacaccag cacctcgcag atttgctcct gtacctgttt caagggatga tgaactatca     1200

aagagggaaa atcttttgga agaaaaagaa aatatggaag tgtcgtgtca cagaggaaat     1260

gtaagactat tggaacaaat tttgaataat aatgattctt tgacaagaaa aagtgaatca     1320

tcaaacacca cctcactaac taggtcaaaa ataggatgga ctcctgagaa aacaaacaga     1380

tttccttcct gtgaagagct agaaacaact aaagtgacta tgcagaagtc tgatgatgtt     1440

cttcatgacc ttggccaaaa agagaaagaa acaaatagca tggtccagcc aaaagaatct     1500

ctgagtatgt tgaagcttcc agatcttcca cagaattctg ttaagcttca aacaaccaat     1560

acaacaagat ctgtattgaa agatgctgag aagattttga gaggagtaca aaacaataaa     1620

aaagtacttg aagaaaacct ggaagctatt attcgtgcaa aagatggagc tgccatgtat     1680

tcgcttatca atgctttatc taccaacaga gagatgtcag agaaaattag gatcagaaag     1740

acagtggatg aatggattaa aactatttct gcagaaattc aggatgaact gtcaagaaca     1800

gattatgaac aaaaaagatt tgatcagaag aatcagagaa ccaagaaagg tcagaatatg     1860

actaaagata ttagaaccaa cacacaagat aaaactgtca acaaatctgt aattccaaga     1920

aaacattctc aaaagcaaat agaagagcat tttagaaatc tacctatgag gggcatgcct     1980

gcttcaagtt tacagaaaga gagaaaggaa gggcttttga aagcaaccac agtaatacaa     2040

gatgaagatt atatgttaca agtctatgga aagccagttt atcagggcca tcgaagcact     2100

cttaaaaaag gaccatatct cagatttaat tctccatctc ctaagtccag accacagaga     2160

ccaaaagtaa tagaacgagt taaaggcact aaggtaaagt caataagaac acagactgac     2220

ttctatgcaa caaaacctaa gaagatggat tctaaaatga aacattctgt tcctgtgtta     2280

cctcatggcg atcagcaata tttgttcagc ccaagtagag aaatgcctac tttttcaggt     2340

acattggaag gtcatctgat tcctatggca attcttttag gacaaaccca aagtaatagt     2400

gataccatgc cacctgctgg agtgattgtc agcaagccac accctgtaac tgtgactact     2460

tctattcctc catcatctcg aaaagtagaa actggagtaa agaaacctaa catagccatt     2520

gtagaaatga agtcagaaaa aaaggatcct cctcagctta ctgtgcaggt attacccagt     2580

gtagatattg acagcatttc aaatagtagt gctgatgtcc tttcacctct gtctagcccc     2640

aaagaagcat ctcttcctcc tgtgcaaact tggataaaga ctccagaaat tatgaaggta     2700

gatgaagaag aggtgaagtt tccaggaact aactttgatg aaataatcga tgtcatacag     2760

gaagaagaaa aatgtgatga aattccagac tctgaaccaa ttctggagtt taacagaagt     2820

gttaaagctg attctacaaa atataatggt cctccatttc cgccagttgc ttctactttt     2880

cagcccactg ctgatattct ggataaagta attgagagaa aagaaacact ggaaaatagc     2940

ttaattcaat gggtagagca agaaataatg tcaagaatta tctctgggct ctttccagtc     3000

cagcaacaga ttgcacctag tatcagtgtt tcagtcagtg agacaagtga accactgact     3060

tctgacattg tggaaggaac aagcagtggc gccctccagc tttttgttga tgctggtgtt     3120

cctgtgaact caaatgtgat taaacatttt gttaacgaag ctcttgctga gaccattgct     3180

gtcatgctgg gtgacagaga agcaaagaag caaggtcctg ttgctacagg tgtttctggg     3240

gatgcttcaa caaatgaaac atatttgccg gcaagagtgt gcaccccact gcctacccca     3300

cagcctacgc ctccttgctc accttcatca cctgctaagg agtgtgtttt ggtaaagact     3360

ccagattctt ctccctgtga ttcggatcat gatatggctt ttcctgtgaa agaaatatgt     3420

gctgaaaaag gagatgatat gcctgccatc atgcttgtta atactccaac agttacccct     3480

actactacac ctcctccagc ggcggcagtt tttaccccaa ctttgtcaga tatttccatt     3540

gataaattga aggtatcaag cccagagctt cccaagccat ggggtgatgg agacctgcca     3600

ctggaagaag agaaccctaa ctcacctcaa gaagaacttc atccaagagc tattgtaatg     3660

tctgtggcta aggatgaaga accagagagt atggatttcc ctgctcagcc tccacctcca     3720

gagccagttc cctttatgcc atttcctgcc ggcaccaagg ccccttcccc ctcacagatg     3780

ccaggttctg attcatcaac actggagagc acattgagtg ttactgtcac tgaaactgaa     3840

actttagata aacccatctc tgaaggagag attttattta gctgtggtca aaaattggcc     3900

cccaagattt tagaagatat aggactgtac ctgacaaacc ttaatgatag cttatccagc     3960

actctgcatg atgccgttga aatggaggat gatcctccta gtgaagggca agtgattagg     4020

atgtcccata aaaaatttca tgcagatgca attctttctt ttgctaaaca aaaccaggag     4080

tcagcagttt cccagcaagc agtctatcat tcagaggact tggaaaacag tgtgggtgaa     4140

cttagtgaag gacaaagacc ccagctaaca gcggcagcag agaacatctt aatgggacat     4200

tctctctata tgcagccacc tgtcactaat acacagtctt tggatcaaca atgtgatcct     4260

aaaccattat ctcggcaatt tgacacagtt tcaggtagta tttatgaaga ttcatgtgct     4320

agtcatggtc caatgagttt gggagaattg gagttggagc caaattctaa gctggttctt     4380

cccacaacac ttctgacagc acaagaaaat gatgttaatt taccagtagc cgctgaagat     4440

ttttcccagt accaactaaa gcaaaatcag gatgttaagc aagttgaaca caaaccatca     4500

caaagttacc tacgtgttag aaataaatct gatattgcac cttcacagca acaagtttca     4560

ccaggtgata tggatcggac acaaattgag cttaatccgt acctcacatg tgtattttca     4620

ggtgggaaag cagtgccact ctccgcttca cagatgcccc ctgccaagat gtcagtgatg     4680

ctgccgtcag tgaacctcga ggactgctct cagtctctga gtctcagcac aatgcaggag     4740

gacatggagt cttcgggggc agataccttc tgaacgggaa gagacagcca gcacagtgtt     4800

tatgccactg gttttaaagt cattttacct tggcttaaaa ccctctctca gactgtttgg     4860

tttttgagca tattctgaaa aaaaaattcc aatattttaa aataaaacaa aaagcataat     4920

ttgggtattt aaagttttta aataaaataa gtataagtca ttataagtct gattgtgagt     4980

tgtttcttag aatcctgaga tagcatagag tagtgaaagg gcatggcttt tgacatctag     5040

gcatttaatc tataggtgta attatctgta tgtatttata aaattatgta gctcaaggtt     5100

attcattcta acatttttat aacagcaaat agaaaaaatc aaatgtctat caataataga     5160

ctggttttaa agtgatggta catcagtaca atggaatact atgtattaca aaaaaaaatt     5220

taaaaagttt attgatatgg aataatcttt gagatgcact gttaaagtga aaaaagccat     5280

gtgcaaaata gtgtgtgaac tatgcagttg ttgaaattat ttaaaatggg gtggggagg      5339


<210> 2960
<211> 2385
<212> DNA
<213> Homo sapiens

<400> 2960
gcgtctcttg tttgtgcggc tgaccagttg gcgacatggt ggcacccgtg ctggagactt       60

ctcacgtgtt ttgctgccca aaccgggtgc ggggagtcct gaactggagc tctgggccca      120

gaggacttct ggcctttggc acgtcctgct ccgtggtgct ctatgacccc ctgaaaaggg      180

ttgttgttac caacttgaat ggtcacaccg cccgagtcaa ttgcatacag tggatttgta      240

aacaggatgg ctccccttct actgaattag tttctggagg atctgataat caagtgattc      300

actgggaaat agaggataat cagcttttaa aagcagtgca tcttcaaggc catgaaggac      360

ctgtttatgc ggtgcatgct gtttaccaga ggaggacatc agatcctgca ttatgtacac      420

tgatcgtttc tgcagctgca gattctgctg ttcgactctg gtctaaaaag ggtccagaag      480

gtagagatct tttcctagca agctgttcac aagattgcct gataagaata tggaagctgt      540

atataaagtc aacatcttta gaaactcagg atgacgataa cataagactg aaagaaaata      600

cttttaccat agaaaatgaa agtgttaaaa tagcatttgc tgttactctg gagacagtgc      660

tagccggtca tgaaaactgg gtaaatgcag ttcactggca acctgtgttt tacaaagatg      720

gtgtcctaca gcagccagtg agattattat ctgcttccat ggataaaacc atgattctct      780

gggctccaga tgaagagtca ggagtttggc tagaacaggt tcgagtaggt gaagtaggtg      840

ggaatacttt gggattttat gattgccagt tcaatgaaga tggctccatg atcattgctc      900

atgctttcca cggagcgttg cacctttgga aacagaatac agttaaccca agagagtgga      960

ctccagagat tgtcatttca ggacactttg atggtgtcca agacctagtc tgggatccag     1020

aaggagaatt tattatcact gttggtactg atcagacaac tagacttttt gctccatgga     1080

agagaaaaga ccaatcacag gtgacttggc atgaaattgc aaggcctcag atacatgggt     1140

atgacctgaa atgtttggca atgattaatc ggtttcagtt tgtatctgga gcagatgaaa     1200

aagttcttcg ggttttttct gcacctcgga attttgtgga aaatttttgt gccattacag     1260

gacaatcact gaatcatgtg ctctgtaatc aagatagtga tcttccagaa ggagccactg     1320

tccctgcatt gggattatca aataaagctg tctttcaggg agatatagct tctcagcctt     1380

ctgatgaaga ggagctgtta actagtactg gttttgagta tcagcaggtg gcctttcagc     1440

cctccatact tactgagcct cccactgagg atcatcttct gcagaatact ttgtggcctg     1500

aagttcaaaa actatatggg cacggttatg aaatattttg tgttacttgt aacagttcaa     1560

agactctgct tgcctcagct tgtaaggcag ctaagaaaga gcatgcagct atcattcttt     1620

ggaacactac atcttggaaa caggtgcaga atttagtttt ccacagtttg acagtcacgc     1680

agatggcctt ctcacctaat gagaagttct tactagctgt ttccagagat cgaacctggt     1740

cattgtggaa aaagcaggat acaatctcac ctgagttcga gccagttttt agtctttttg     1800

ccttcaccaa caaaattact tctgtgcaca gtagaattat ttggtcttgt gattggagtc     1860

ctgacagcaa gtatttcttc actgggagtc gagacaaaaa ggtggttgtc tggggtgagt     1920

gcgactccac tgatgactgt attgagcaca acattggccc ctgctcctca gtcctggacg     1980

tgggtggggc tgtgacagct gtcagcgtct gcccagtgct ccacccttct caacgatacg     2040

tggttgcagt aggattggag tgtggaaaga tttgcttata tacctggaaa aagactgatc     2100

aagttccaga aataaatgac tggacccact gtgtagaaac aagtcaaagc caaagtcata     2160

cactggctat cagaaaatta tgctggaaga attgcagtgg aaaaactgaa cagaaggaag     2220

cagaaggtgc tgagtggtta cactttgcaa gctgtggtga agatcacact gtgaagatac     2280

acagagtcaa taaatgtgca ctgtaatgga cttaataact acatgcttgc agtcactggt     2340

atcttaaaat attatcatgt aaacaggtca tctttacctt cataa                     2385


<210> 2961
<211> 524
<212> DNA
<213> Homo sapiens

<400> 2961
gtgcgccctt ccccgcgcgc ggcccctcct gctgggctgg ggtctgtggc tgacgtccgc       60

ttttcccgga acggcaaaga gaagtcattc agaattcaaa agaagttcta agtttattgc      120

aagaaaaaaa ccctgccttc aagccggttc ttgcaattat ccaggcaggt gacgacaact      180

tgatgcagga aatcaaccag aatttggctg aggaggctgg tctgaacatc actcacattt      240

gcctccctcc agatagcagt gaagccgaga ttatagatga aatcttaaag atcaatgaag      300

ataccagagt acatggcctt gcccttcaga tctctgagaa cttgtttagc aacaaagtcc      360

tcaatgcctt gaaaccagaa aaagatgtgg atggagtaac agacataaac ctggggaagc      420

tggtgcgagg ggatgcccat gaatgttttg tttcacctgt tgccaaagct gtaattgaac      480

ttcttgaaaa atcaggtgtc aacctagatg gaaagaagat tttg                       524


<210> 2962
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 2962
acggggcggg gacgagctgt cgcgctggtt gctcgtgcag gagcgggacc cggaacagac       60

cgccgtgaga gaggaggggc gccggccggg attcgcggcc cggagctcgg gaccggagtc      120

aggaatggag agaagggtaa tggttttacc tcttattgtg gaaacctgtt gagatcacag      180

agaatatact gacggcataa aagggcagaa ccatagcagg gtgcggttgc ttcattccag      240

cctcgcagtc acctctgtgc cctgctggtt gtcttcccag cgctgctgta gttgccttcc      300

atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg aacggagacc      360

tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg aagaggaggt      420

gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact gtggccacgt      480

cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc ccgtctgccc      540

actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac tggccagcct      600

ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag aggtgacccg      660

ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact actactgtga      720

ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca ggccccacac      780

ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga accacctgag      840

taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag aagctgatat      900

cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg agtttgagca      960

gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg cgaagctgga     1020

gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg agcttgcccg     1080

gctggccctg gtcatctccg aactggaggg caaggcgcag cagc                      1124


<210> 2963
<211> 1868
<212> DNA
<213> Homo sapiens

<400> 2963
tttggtgctc aagagaggct tggaggagac cacagttctt tctccatgtg tgaggaatta       60

aaggcaactg tgcagaaaca cacgcagagc ctgaagccca gcaaggagga tctgaacagg      120

cttaatcagg ccatccagtg gctgacggtg gaggtgggca gtgctgagag tcagcaccat      180

gacttgtgga tcttactgtg gtggccgcgc cttcagctgc atctcggcct gcgggccccg      240

gcccggccgc tgctgcatca ccgccgcccc ctaccgtggc atctcctgct accgcggcct      300

caccgggggc ttcggcagcc acagcgtgtg cggaggcttt cgggccggct cctgcggacg      360

cagcttcggc taccgctccg ggggcgtgtg cgggcccagt cccccatgca tcaccaccgt      420

gtcggtcaac gagagcctcc tcacgcccct caacctggag atcgacccca acgcgcagtg      480

cgtgaagcag gaggagaagg agcagatcaa gtccctcaac agcaggttcg cggccttcat      540

cgacaaggtg cgcttcctgg agcagcagaa caaactgctg gagacaaagc tgcagttcta      600

ccagaaccgc gagtgttgcc agagcaacct ggagcccctg tttgagggct acatcgagac      660

tctgcggcgg gaggccgagt gcgtggaggc cgacagcggg aggctggcct cagagcttaa      720

ccacgtgcag gaggtgctgg agggctacaa gaagaagtat gaggaggagg tttctctgag      780

agcaacagct gagaacgagt ttgtggctct gaagaaggat gtggactgcg cctacctccg      840

caaatcagac ctggaggcca atgtggaggc cctgatccag gagatcgact tcctgaggcg      900

gctgtatgag gaggagatcc gcgttctcca gtcccacatc tcagacacct ccgtggttgt      960

caagctggac aacagccggg acctgaacat ggactgcatc attgccgaga tcaaggcaca     1020

gtacgatgac attgtcaccc gtagccgggc tgaggccgag tcctggtacc gcagcaagtg     1080

tgaggagatg aaggccacgg tgatcaggca cggggagacc ctgcgccgca ccaaggagga     1140

gatcaacgag ctgaaccgca tgatccagag gctgacggct gaggtggaga atgccaagtg     1200

ccagaattcc aagctggagg ctgcggtggc tcagtctgag cagcagggtg aggcggccct     1260

cagcgatgcc cgctgcaagt tggccgagct ggagggtgcc ctgcagaagg ccaagcagga     1320

catggcctgc ctgatcaggg agtaccagga ggtgatgaac tccaagctgg gcctggacat     1380

cgagatcgcc acctacaggc gcctgctgga gggcgaggag cagaggctgt gcgagggcgt     1440

cggctcggtg aatgtctgcg tcagcagctc ccgcggtggc gttgtctgtg gcgatctctg     1500

cgcctccact actgcccctg ttgtctccac cagagtcagt agcgtcccca gcaacagcaa     1560

cgtggtggtg ggcactacta acgcctgcgc cccctccgcc cgggttggcg tctgcggcgg     1620

cagctgtaag aggtgctagg aggctgccgc ctccgccagc gcctgtcgcc gtcactctcc     1680

acccagccag tacctcgcgc caccagaacg cgccgcccgc gccggcctcc caatagccgc     1740

cgcccgctgc ctgcactcta agcgccctcc ccaccgctcc gctccgggag ccatccccgg     1800

tcgcaggagt ccggggaggg ccgggaggcg ccatggtctc tctctgtagc ctttcctggt     1860

agtcaatt                                                              1868


<210> 2964
<211> 2238
<212> DNA
<213> Homo sapiens

<400> 2964
atggctctgc tgtccgaggg cctggacgag gtgcccgccg cctgcctgtc gccgtgcggg       60

ccgcccaacc cgaccgagct gttcagcgag tcacggcgcc tggctctgga ggagctggtg      120

gcgggcggcc ccgaagcctt cgcggccttc ctgcgacgcg agcgcctggc tcgtttcctg      180

aaccccgatg aggtgcacgc cattctgcgc gcggcggaga ggccgggaga ggagggcgcg      240

gcggcggcgg cggcggccga ggactcgttc ggctcctcgc acgactgctc ttcgggcacc      300

tacttccccg agcagtcgga cctggagcca ccgctgttgg agcttggctg gcccgccttc      360

taccagggcg ctggcgaagg tggcccctac ggctgcaagg acgctctgcg ccagcagctc      420

cgctcggcgc gagaggtgat tgcagtggtc atggacgtgt tcacagacat cgacatcttc      480

agagacctgc aagaaatatg caggaaacag ggagttgctg tgtatatcct tctggaccag      540

gctctcctct ctcaatttct ggatatgtgc atggatctga aagttcatcc tgaacaggaa      600

aagttaatga cagttcggac tatcacagga aatatctact atgcaaggtc aggaactaag      660

attattggga aggttcacga aaagttcacg ttgattgatg gcatccgcgt ggcaacaggc      720

tcctacagtt ttacatggac ggatggcaaa ttaaacagca gtaacttggt aattctgtct      780

ggccaagtgg ttgaacactt tgatctggag ttccgaatcc tgtatgccca gtccaagccc      840

atcagcccca aactcctgtc tcacttccag agcagcaaca agtttgatca cctcaccaac      900

cgaaaaccac agtccaagga gctcaccctg ggcaacctgc tgcggatgcg gctggctagg      960

ctgtcaagta ctcccaggaa ggcggacctg gacccagaga tgcccgcaga gggcaaggca     1020

gagcgcaagc cccatgactg tgagtcctct actgttagtg aggaagacta cttcagcagc     1080

cacagggacg agctccagag cagaaaggcc attgacgctg ccactcaaac agagccagga     1140

gaggagatgc cagggctgag tgtgagtgag gtgggaacac aaaccagcat caccacagca     1200

tgtgctggta cccagactgc agtcatcacc aggatagcaa gctctcaaac cacgatttgg     1260

tccagatcga ccactactca gactgacatg gatgagaaca ttctctttcc tcgaggaact     1320

caatctacag aagggtcacc agtctcaaaa atgtctgtat cgagatcttc cagtttgaag     1380

tcttcctcct ctgtgtcttc ccaaggctct gtggcaagct ccactggttc tcccgcttcc     1440

atcagaacca ctgacttcca caatcctggc tatcccaagt acctgggcac cccccacctg     1500

gaactgtact tgagtgactc acttagaaac ttgaacaaag agcggcaatt ccacttcgct     1560

ggtatcaggt cccggctcaa ccacatgctg gctatgctgt caaggagaac actctttact     1620

gaaaaccacc ttggccttca ttctggcaat ttcagcagag ttaatttgct tgctgttaga     1680

gatgtagcac tttatccttc ctatcagtaa ctgctccgtg ttcagactcc tggtttcttc     1740

caggcttaca gtggacatca tcagcttcct gctttaaaaa atatcttatg tccctaattg     1800

cctttctttt acctgacttt gtcacctttg ttgtctttga attctttagg ctgcatatta     1860

ttttacatgc tttgttttgt catgtatata ccaggtattg gttttatggt ttaaacacta     1920

tggatacagg ggtttgtttt gcacaatttt aatagtcatg cactacataa tgatgttttg     1980

gtcaatgaca gaccacgtat atgttggcag tctcataaga ttataatact gtatttttac     2040

tatacctttt ctgtgtttag atacaaatac cattatgtta cagttgccta cagtattcag     2100

tgcagtaaca tgatgtacag gtttgtagcc tgttttgcat ttttcttagg ttgtatgctc     2160

ttctgtttta aaggtttgaa tcaccagcat ttttgtgatc aaaatcctat ttagaaaaaa     2220

taaaactact ttctgttt                                                   2238


<210> 2965
<211> 10861
<212> DNA
<213> Homo sapiens

<400> 2965
cgccccccct gcgcccgccc ctcccccttc gctttccttc tccccccgcc tcggctccga       60

catgaggggc cggcggggca ggccgcccaa gcagcccgcg gctcccgctg cggagcgctg      120

cgccccggcc ccgccgccac cgccgccgcc gcccacgtcc ggacccatcg gggggctccg      180

ctcgcggcac cgcggcagca gccggggcag gtgggccgcc gcccaggctg aggtggcgcc      240

caagacgcgg ctgagctcgc ccaggggggg cagcagtagc cggaggaagc cgccgccgcc      300

gccgccggcc ccccccagca ccagcgcccc gggccggggg gggcgaggag gcgggggcgg      360

caggacgggg ggcgggggcg gcggcggcca cctggcccgg accaccgcgg cccggagggc      420

cgtcaacaaa gtggtgtacg atgaccacga gagcgaggag gaggaggaag aggaggacat      480

ggtctccgag gaggaggagg aggaggacgg cgacgccgag gagacccagg attctgagga      540

cgacgaggag gatgagatgg aagaggacga cgatgactcc gattatccgg aggagatgga      600

agacgacgac gacgacgcca gttactgcac ggaaagcagc ttcaggagcc atagtaccta      660

cagcagcact ccaggtaggc gaaaaccaag agtacatcgg cctcgttctc ctatattgga      720

agaaaaagac atcccgcccc ttgaatttcc caagtcctct gaggatttaa tggtgcctaa      780

tgagcatata atgaatgtca ttgccattta cgaggtactg cggaactttg gcactgtttt      840

gagattatct ccttttcgct ttgaggactt ttgtgcagct ctggtgagcc aagagcagtg      900

cacactcatg gcagagatgc atgttgtgct tttgaaagca gttctgcgtg aagaagacac      960

ttccaatact acctttggac ctgctgatct gaaagatagc gttaattcca cactgtattt     1020

catagatggg atgacgtggc cagaggtgct gcgggtgtac tgtgagagtg ataaggagta     1080

ccatcacgtt cttccttacc aagaggcaga ggactaccca tatggaccag tagagaacaa     1140

gatcaaagtt ctacagtttc tagtcgatca gtttcttaca acaaatattg ctcgagagga     1200

attgatgtct gaaggggtga tacagtatga tgaccattgt agggtttgtc acaaacttgg     1260

ggatttgctt tgctgtgaga catgttcagc agtataccat ttggaatgtg tgaagccacc     1320

tcttgaggag gtgccagagg acgagtggca gtgtgaagtc tgtgtagcac acaaggtgcc     1380

tggtgtgact gactgtgttg ctgaaatcca aaaaaataaa ccatatattc gacatgaacc     1440

tattggatat gatagaagtc ggaggaaata ctggttcttg aaccgaagac tcataataga     1500

agaagataca gaaaatgaaa atgaaaagaa aatttggtat tacagcacaa aggtccaact     1560

tgcagaatta attgactgtc tagacaaaga ttattgggaa gcagaactct gcaaaattct     1620

agaagaaatg cgtgaagaaa tccaccgaca catggacata actgaagacc tgaccaataa     1680

ggctcggggc agtaacaaat cctttctggc ggcagctaat gaagaaattt tggaatccat     1740

aagagccaaa aagggagaca ttgataatgt taaaagccca gaagaaacag aaaaagacaa     1800

gaatgagact gagaatgact ctaaagatgc tgagaaaaac agagaagaat ttgaagacca     1860

gtcccttgaa aaagacagtg acgacaaaac accagatgat gaccctgagc aaggaaaatc     1920

tgaggagcca acagaagttg gggataaagg taactctgtg tcagcaaatc ttggcgacaa     1980

cacaacaaat gcaacttcag aagagactag tccctctgaa gggaggagcc ctgtggggtg     2040

tctctcagaa acccccgata gcagcaacat ggcagagaag aaggtggcat ctgagctccc     2100

ccaggatgtg ccagaagaac ctaacaagac atgtgagagc agtaacacta gtgctaccac     2160

tacctccatc cagcctaatc tggaaaacag taacagcagc agtgaactaa attcttccca     2220

gagtgaatct gctaaggcag ctgatgatcc tgaaaatgga gaaagagaat ctcatacacc     2280

tgtctctatt caggaagaga tagtaggtga tttcaaatcg gagaagtcca acggggagct     2340

aagtgaatct cctggagctg gaaaaggagc atctggctca actcgaatca tcaccagatt     2400

gcggaatcca gatagcaaac ttagtcagct gaagagccag caggtggcag ccgctgcaca     2460

tgaagcaaat aaattattta aggagggcaa agaggtactg gtagttaact ctcaaggaga     2520

aatttcacgg ttgagcacca aaaaggaagt gatcatgaaa ggaaatatca acaattattt     2580

taaattgggt caagaaggga agtatcgcgt ctaccacaat caatactcca ccaattcatt     2640

tgctttgaat aagcaccagc acagagaaga ccatgataag agaaggcatc ttgcacataa     2700

gttctgtctg actccagcag gagagttcaa atggaacggt tctgtccatg ggtccaaagt     2760

tcttaccata tctactctga gactgactat cacccaatta gaaaacaaca tcccttcatc     2820

ctttcttcat cccaactggg catcacatag ggcaaattgg atcaaggcag ttcagatgtg     2880

tagcaaaccc agagaatttg cattggcttt agccattttg gagtgtgcag ttaaaccagt     2940

tgtgatgcta ccaatatggc gagaatcttt aggacatacc aggttacacc ggatgacatc     3000

aattgaaaga gaagaaaagg agaaagtcaa aaaaaaagag aagaaacagg aagaagaaga     3060

aacgatgcag caagcgacat gggtaaaata cacatttcca gttaagcatc aggtttggaa     3120

acaaaaaggt gaagagtaca gagtgacagg atatggtggt tggagctgga ttagtaaaac     3180

tcatgtttat aggtttgttc ctaaattgcc aggcaatact aatgtgaatt acagaaagtc     3240

gttagaagga accaaaaata atatggatga aaatatggat gagtcagata aaagaaaatg     3300

ttcacgaagt ccaaaaaaaa taaaaataga gcctgattct gaaaaagatg aggtaaaagg     3360

ttcagatgct gcaaaaggag cagaccaaaa tgaaatggat atctcaaaga ttactgagaa     3420

gaaggaccaa gatgtgaagg agctcttaga ttctgacagt gataaaccct gcaaggaaga     3480

accaatggaa gtagacgatg acatgaaaac agagtcacat gtaaattgtc aggagagttc     3540

tcaagtagat gtggtcaatg ttagtgaggg ttttcatcta aggactagtt acaaaaagaa     3600

aacaaaatca tccaaactag atggacttct tgaaaggaga attaaacagt ttacactgga     3660

agaaaaacag cgactcgaaa aaatcaagtt ggagggtgga attaagggta taggaaagac     3720

ttctacaaat tcttcaaaaa atctctctga atcaccagta ataacgaaag caaaagaagg     3780

gtgtcagagt gactcgatga gacaagaaca gagcccaaat gcaaataatg atcaacctga     3840

ggacttgatt cagggatgtt cagaaagtga ttcctcagtt cttagaatga gtgatcctag     3900

tcataccaca aacaaacttt atccaaaaga tcgagtgtta gatgatgtct ccattcggag     3960

cccagaaaca aaatgtccga aacaaaattc cattgaaaat gacatagaag aaaaagtctc     4020

tgaccttgcc agtagaggcc aggaacccag taagagtaaa acaaaaggaa atgatttttt     4080

catcgatgac tctaaactag ccagtgcaga tgatattggt actttgatct gtaagaacaa     4140

aaaaccgctc atacaggagg aaagtgacac cattgtttct tcttccaaga gtgctttaca     4200

ttcatcagtg cctaaaagta ccaatgacag agatgccaca cctctgtcaa gagcaatgga     4260

ctttgaagga aaactgggat gtgactctga atctaatagc actttggaaa atagttctga     4320

taccgtgtct attcaggata gcagtgaaga agatatgatt gttcagaata gcaatgaaag     4380

catttctgaa cagttcagaa ctcgagaaca agatgttgaa gtcttggagc cgttaaagtg     4440

tgagttggtt tctggtgagt ccactggaaa ctgtgaggac aggctgccgg tcaaggggac     4500

tgaagcaaat ggtaaaaaac caagtcagca gaagaaatta gaggagagac cagttaataa     4560

atgtagtgat caaataaagc taaaaaatac cactgacaaa aagaataatg aaaatcgaga     4620

gtctgaaaag aaaggacaga gaacaagtac atttcaaata aatggaaaag ataataaacc     4680

caaaatatat ttgaaaggtg aatgcttgaa agaaatttct gagagtagag tagtaagtgg     4740

taatgttgaa ccaaaggtta ataatataaa taaaataatc cctgagaatg atattaaatc     4800

attgactgtt aaagaatctg ctataaggcc attcattaat ggtgatgtca tcatggaaga     4860

ttttaatgaa agaaacagct ccgaaacaaa atcgcatttg ctgagttctt cagatgctga     4920

aggtaactac cgagatagcc ttgagaccct gccatcaacc aaagagtctg acagtacaca     4980

gacgaccaca ccctcagcat cttgtccaga aagcaattca gttaatcagg tagaagatat     5040

ggaaatagaa acctcagaag ttaagaaagt tacttcatca cctattactt ctgaagagga     5100

atctaatctc agtaatgact ttattgatga aaatggtctg cccatcaaca aaaatgaaaa     5160

tgtcaatgga gaatctaaaa gaaaaaccgt catcacagaa gtcaccacga tgacctccac     5220

agtggccaca gaatcaaaaa ctgtgatcaa ggtagaaaaa ggcgataagc aaactgtggt     5280

ttcttccaca gaaaattgtg caaaatccac tgtcacaacc accactacaa cagtgaccaa     5340

gctttccaca ccctccacag gcggcagtgt ggacatcatc tctgtaaagg agcagagcaa     5400

aaccgtggtc accacgacag tgacagactc cctgaccacc acgggaggca cactggttac     5460

atctatgact gtgagcaaag agtattccac acgagacaaa gtgaaactga tgaaattttc     5520

aagaccaaag aagactcgtt caggtacagc tctgccatcc tatagaaaat ttgttaccaa     5580

gagcagcaag aagagcattt ttgttttgcc taatgatgac ttaaaaaagt tggcccgaaa     5640

aggaggaatc cgagaggtcc cttattttaa ttacaatgca aaacctgctt tggatatatg     5700

gccatatcct tctcctagac cgacctttgg catcacttgg aggtatagac ttcagacagt     5760

aaagtcctta gctggagtga gcctgatgtt acggttactg tgggcaagtt tgagatggga     5820

tgatatggcg gccaaggctc ctccaggagg agggactaca cggacagaaa catccgaaac     5880

tgaaatcaca acaacagaaa taattaagag gagagatgtt ggtccttatg gcattcgatc     5940

tgaatattgt atcaggaaaa tcatttgtcc cattggagtt ccagaaacac caaaagaaac     6000

gcctacacct cagaggaaag gccttcgatc aagtgcactg cggccaaaga gaccagaaac     6060

gcccaagcaa actggccctg ttattattga aacctgggta gcagaagaag aactggaatt     6120

gtgggagatc agggcatttg ctgagagagt ggagaaagaa aaggcacaag cagttgagca     6180

acaggctaag aaacgactgg agcagcagaa gccgacagtg attgcaactt ccactacttc     6240

cccaacaagc agtacaacca gcaccatctc tccagcacag aaggttatgg tggcccccat     6300

aagtggctca gttacaactg gaaccaaaat ggtactaact actaaagttg gatctccagc     6360

tacagtaaca ttccaacaaa acaagaactt tcatcaaacc tttgctacat gggttaagca     6420

aggccagtca aattcaggcg ttgttcaagt acagcagaaa gtcctgggta tcattccatc     6480

aagtacaggt accagtcagc aaacctttac ttcattccag cccaggacag caacagtcac     6540

aattaggccc aatacctcag gctctggagg aaccacaagc aattcacaag taatcacagg     6600

gcctcagatt cgccctggta tgaccgtgat tagaacacca ctccaacagt caacactagg     6660

aaaggcaatt attcgaacac ctgtgatggt acagccaggt gctcctcagc aagtgatgac     6720

tcaaatcatc agggggcagc ctgtctccac tgcagtctcc gcccctaaca cggtttcctc     6780

aacacctggg cagaaaagct taacttcagc aacgtccact tcaaatatac agtcttcagc     6840

ctcacaaccc cctcgccccc aacaaggaca agtgaagctc accatggctc aacttactca     6900

gttaacacag ggccacggtg gcaatcaagg tttgacagta gtaattcaag gacaaggtca     6960

aactactgga cagttgcagt tgatacctca aggggtgact gtactcccag gcccaggcca     7020

gcagctaatg caagctgcaa tgccaaatgg tactgttcag cgattcctct ttaccccatt     7080

ggcaacaaca gccaccacag ccagcaccac caccaccact gtttccacga cagcagcagg     7140

tacaggtgaa caaaggcaga gtaaactgtc accccagatg caggtacatc aagacaaaac     7200

cctgccacca gctcagtcat caagtgtggg tccagcagaa gcccagccac agactgctca     7260

gccttcagct cagccccagc cccaaaccca gccccagtcc ccagctcagc ctgaagttca     7320

gactcagcct gaagttcaga cccaaacaac tgtttcatcc catgtccctt ctgaagcaca     7380

acccacccac gcacagtcat ccaagcccca agttgcagca gtctcagcct caaagtaatg     7440

tccaaggaca gtctcctgtt cgtgtccaaa gtccatcaca gactcgaata cgtccatcaa     7500

ctccatccca actgtctcct ggacaacaat cccaggttca gactacaacc tcacaaccga     7560

ttccaattca accacataca tctcttcaga taccttccca aggccagcca cagtcacaac     7620

cccaggtggt gatgaagcat aatgctgtaa tagaacattt aaaacagaaa aagagcatga     7680

ctccagctga aagagaagag aatcaaagaa tgattgtctg taaccaggtg atgaagtata     7740

ttttggataa gatagataaa gaagaaaaac aggcagcaaa aaaacggaag cgtgaagaga     7800

gtgtggagca gaaacgtagc aagcagaatg ccactaagct gtcagctctg ctcttcaagc     7860

acaaagagca gctcagagcc gagatcctga agaagagagc actcctggac aaggatctgc     7920

aaattgaagt gcaggaagag ctgaagagag acctgaaaat taagaaagaa aaagacctga     7980

tgcagttggc tcaggccaca gcagtagctg caccctgccc cccagtgaca ccagctcctc     8040

cagcccctcc agcccctcca ccttcacctc cccctccacc tgctgtgcaa cacacaggcc     8100

ttctgtccac gcccacctta cctgctgctt cccagaagag gaagcgggaa gaggaaaaag     8160

actccagctc aaagtccaag aaaaagaaaa tgatctctac tacctcaaag gaaactaaga     8220

aggacacaaa gctttactgt atctgtaaaa cgccttatga tgaatctaaa ttttatattg     8280

gctgtgatcg gtgtcagaat tggtaccatg ggcgctgcgt tggcatcttg caaagtgagg     8340

cagagctcat tgatgagtat gtctgtccac agtgccagtc aacagaggat gccatgacag     8400

tgctcacgcc actaacagag aaggattatg aggggttgaa gagggtgctc cgttccttac     8460

aggcccataa gatggcctgg cctttccttg aaccagtaga ccctaatgat gcaccagatt     8520

attatggtgt tattaaggaa cctatggacc ttgccaccat ggaagaaaga gtacaaagac     8580

gatattatga aaagctgacg gaatttgtgg cagatatgac caaaattttt gataactgtc     8640

gttactacaa tccaagtgac tccccatttt accagtgtgc agaagttctc gaatcattct     8700

ttgtacagaa attgaaaggc ttcaaagcta gcaggtctca taacaacaaa ctgcagtcta     8760

cagcttctta aagttcagcg tgttaaccta acataaaaca cagcaagaat ctggttgtct     8820

gaactatttt aaattaagga gccagatgtt tttagtcagg ctatcctgac aagacttgac     8880

ctaaacttcg tttttattgg tcataacagt ccaattatat tcttggccaa ttttgtccaa     8940

cggacaagaa aaaagcaaag tcaacgacac cattatcttg tcaagatcag atggttttac     9000

tattgtggca gaagcgagaa aactttgttt attgaaaaaa aaagaaaaag aaagcaagaa     9060

aaaaagatac tatggggtca agtgtaactc catggaaatg ccacgtctgc tcttcagtga     9120

agaagctggt ttagagtctc acagaaaact tttgactgta tttatttatt gttgcaaaaa     9180

agacgctttt ttattgctgc cctcatttgt cagctaatta ttttttctta taaaatccag     9240

ccccggttac atataatcat ctgtatctta tcatgattcc tgtaggtaaa agtacaagac     9300

gacctctaga tgtcttttct ttctatgaaa ggagctgcta tgtacacatg tgcacacaca     9360

cacaactggg aatcaacaat gagtttattg ttcatggtag attaaaatta agcttgcata     9420

aaggttgggc taagtggtcc tggactacag actctgttgc cttgaatata acagtacaat     9480

ttgtcaatta ctctgcacca ggctaaaatg agtaaaatct atttgaaggt atcttgtttg     9540

taaacatttg tcagattcta atttttttct tttgtattaa aattcaacta tggatgtata     9600

tgaaacaaaa taaatggaga taatttttct cccacagaca gaggtgtctt tgaatgtgcg     9660

ctaatgatta tctgtaagcc tttgtgggga gggaggcctg caaggtcatg aaaggcagaa     9720

gagtctaatt gtgcctggat ttctccagga cagcagtggc ccctcgtttt atcattccca     9780

gtccattgtc atcacgtcag agaaaaatct tcaggggtgc taatcctgtt gcatcagttg     9840

atcatactaa cgagaacggt aatgcgacaa gatacacatt gccttcatct gtacattctg     9900

tgataccagg caaattacca attacacaca gctacttata ttttatgaag ggcatttttt     9960

agatgacctc atcctctgtg ttatttgttg attgggtttg ttttctgttt gttggtttgt    10020

ttgtttcttc cacgtaagga aaagtagtgt aaacagtagc gagaaaatgg aaaccacaga    10080

ggaagatgta ttttgcatgt ttttcctttc agtgttctta cacgttgtat cactgcattg    10140

tggtaatagc ttctataaaa tctgccatag ttggattatg cagctttgca aaaattttta    10200

ctagattttg cactaactca tattagcttt gtcctaccaa cttctggaat ttatctaatt    10260

attgtttttc aaagtttctt tccttttaat gtttccctgc tatgcaaaac ctttcccaga    10320

cctcagtttc ttaaaagaaa gatgttgcta cagttcccga ttctttctta ttacaggctc    10380

aggtgtacag gttattctgg gttaatttta tctaatgaag cccattcctt tttgtacata    10440

aagatgtcac ttaaacttat gcttacaaac taaagactaa tcgctcaata tgaaaacatg    10500

aaaaaatttt tgcttaaagt attaagatgg aagtagttaa atatgggtta ttttgtcctt    10560

ttactttttt aaaaaatgtt acatattgta tgcactgtgc tgatgcaaga attctacatt    10620

ttaatgagtt ataaaattat tctgcatctc atcacgtcac agtatttctg tactatttat    10680

tcatatatat aaatatatat gggcttaatc atttaaaatt tgttgcagca agaactttcc    10740

tacctgtagg caatagattg ctatgttttt aacaaattgt ggcaaattct aaacagcaat    10800

tcttttgtac gtaataggac atttcatcct agaaaaataa agtaatgttt ttgacattgg    10860

a                                                                    10861


<210> 2966
<211> 682
<212> DNA
<213> Homo sapiens

<400> 2966
ggaaacctgt tgagatcaca gagaatatac tgacggcata aaagggcaga accatagcag       60

ggtgcgcctc gcagtcacct ctgtgccctg ctggttgtct tcccagcgct gctgtagttg      120

ccttccatgg atctatagga gagcaagtcc tccaggagaa gaagtcctca ccagtgaacg      180

gagacctctc tgaactaagg ataccatggc cacgtcagcc ccactacgga gcctggaaga      240

ggaggtgacc tgctccatct gtcttgatta cctgcgggac cctgtgacca ttgactgtgg      300

ccacgtcttc tgccgcagct gcaccacaga cgtccgcccc atctcaggga gccgccccgt      360

ctgcccactc tgcaagaagc cttttaagaa ggagaacatc cgacccgtgt ggcaactgga      420

aaaaatcctg aaccacctga gtaccctaag gagggacaga gacaaaattc agggcttcca      480

ggcaaaggga gaagctgata tcctggccgc gctgaagaag ctccaggacc agaggcagta      540

cattgtggct gagtttgagc agggtcatca gttcctgagg gagcgggagg aacacctgct      600

ggaacagctg gcgaagctgg agcaggagct cacggagggc agggagaagt tcaagagccg      660

gggcgtcggg gagcttgccc gg                                               682


<210> 2967
<211> 1738
<212> DNA
<213> Homo sapiens

<400> 2967
aaagttccgg gtgaggcgtg ggtcccacaa ccgcttggaa tttgcctccc ggctccgctc       60

tggaagctaa gaaggggcac gagagccgga gacgggaacc tgagagcagg gaagccagta      120

gccggccgga ggagcgcgcg gccgctccag tcggaaggag ccgttgcagc cctgcccggc      180

gtgtggcggg gtcagcgagg cccctgcggt gcttcgcccg cgccttccgc tccgcactca      240

cccgccctct gggcctccca caggaatcaa agatcaactc ccactgagga caaatggacc      300

tgtaattccg ggtgtgacga gagaacgaga tttaccttcc tgaattaaaa aacaggtcat      360

taagcttggg ccctgactct tctttgtgag aaggtacaga gatggaaacc ttacaatccg      420

agactaaaac gagggtcctt ccctcatggc tgacagccca ggtggctaca aagaatgtgg      480

caccaatgaa ggcccccaag aggatgagaa tggcagcagt gccagtggca gcagcaaggt      540

gcgacagctc tggtcagaag actcctgcga atctgactcc ctgcgacaag gactgtgtac      600

tgcatgaatg aggctgagat agttgatgtt gctctgggaa tcctgattga gagccgcaaa      660

caggaaaagg cctgcgagca gccggccctg gcgggggctg ataacccaga gcactcccct      720

ccctgctccg tgtcgcctca cacaagttct gggagcagca gtgaggaaga ggacagtggg      780

aaacaggcac tggctccagg cctcagccct tcccagaggc cggggggttc cagctctgcc      840

tgtagcagga gccctgagga ggaggaggaa gaggatgtgc tgaaatacgt ccgggagatc      900

tttttcagct agggcataaa ctgtgcactg aactgtctgc cgagagcagc tggaggacag      960

ctgagcttcc actggtgctg ctgggccgcc cgcctgtggg aatggggctc tctgtgctcc     1020

tacctttgtg ccttcttggg cctggcagat tcacctcagg ccagaagccc ctggacactc     1080

cgggccttgg ggctgccgtt ctgagtgtgc ggaaggcagg actcaaaatg agatcccatt     1140

tgactccctc tgtatgtact gtgccctctc ctggctcttg aggctctgga gtcccaattg     1200

tctgtgttag tcagtgacca ggttccaggg aaaatgatgt catgtggtgg tccaacttac     1260

tggaaccaaa gagacagtac tttgcaaaga aaaggatcac tgccaggtgc actggaattg     1320

ctacagttta gtccgcatga tctctcctga aggaggaagc ctgtttcaaa aatagtttcc     1380

atcatgagtc tatcaatgag ctcccacctc tccagccagc ctagaaagca aacgagctgc     1440

ccacagttct ctgccctgtc tgggaggttg aggccacagt gtatagactg gtaagccaga     1500

caggcctcct cccgcaagct gctaccttgc tttcacctgt accttggtcc ccgggcagct     1560

agctataaag caagagggac aggagcccag aagagacact gaggacaaga gatcacacca     1620

gagtacatgt ctctgcctct gttttcagtg tggctttgga caggaatata tgaataaatc     1680

actgccatac aggttttcca atacacaagt gctagaaaat acacacaatt ccccaatg       1738


<210> 2968
<211> 577
<212> DNA
<213> Homo sapiens

<400> 2968
ttctttccag ggaagaaggg cggggatgtc agggctggag agtgcccgtg tccttctgtg       60

tgcattgggc tccttcctcc ttaattctct gctttccact tttaggctga actccagtgc      120

acccagttag acttggagcg gaaactcaag ttgaatgaaa atgccatctc caggctccag      180

gctaaccaaa agtctgttct ggtgtcggtg tcagaggtca aagcagtggc tgaaatgcag      240

tttggggaac tccttgctgc tgtgaggaag gcccaggcca atgtgatgct cttcttagag      300

gagaaggagc aagctgcgct gagccaggcc aacggtatca aggcccacct ggagtacagg      360

agtgccgaga tggagaagag taagcaggag ctggagacga tggcggccat cagcaacact      420

gtccagttct tggagaggag tatgacatca gaactcaagt gtctgccatt gttcagcgca      480

aatattggac ttccaaacct gagcccagca ccagggaaca gttcctccaa tatgtgcatg      540

acatcacgtt cgacccggac acagcacaca agtatct                               577


<210> 2969
<211> 1162
<212> DNA
<213> Homo sapiens

<400> 2969
cccaaacaga gcgttttctg gtccccgagc tcctcccgac cccacccgct cctacggcct       60

ccaaccggcc ccccccaggt gtgtgcagtg gcctcaggga tccggaaagt ctaggactga      120

acttctccta acatccagta atggggacct ggaacctggg cttactagag tgccgcgcgt      180

agggctccag gtcgctggct tctgcgcttc cttcctctcc aaagttgagt atctcctatc      240

tgtgtcctcg tacatactgc cgcctgaggt gccatggccc ccaagccggg ggccgagtgg      300

agcacagccc tgtcccatct ggtgctggga gtggtgtctc tgcacgcagc cgtgagcaca      360

gccgaggcaa gtcgaggggc tgctgctggc ttcctgctcc aggtcttggc tgccaccacc      420

acgctggccc cagggctgag cacacacgaa gactgccttg ctggagcctg ggtggccacc      480

gtcatcggcc ttccccttct ggccttcgat ttccactggg tgaatgggga ccgctcctct      540

gccaacctgc tcctgggagg aggcatggtg ctggcagtgg ctggcggcca cctcggccct      600

gagggccgct ctgtggctgg tcaggcaatg ctgttggtgg tcgcagtgac catcctcatt      660

gtagctgtct tcacggccaa cacttatggg atgtgggggg gggcgatgct gggtgtggca      720

ggcctcctga gccggctgga ggaggacagg ctgctgctgc taccgaagga ggatgtctgt      780

cgctgggcct tggctgtagg cagctgggct tactgccggg ccctgcatac acagcgcctc      840

cagtgggagt gacagttgga tacagccagg cagggtttct gccctgccga acactttccc      900

tcccacctgc ctgctcctgg cgccttctcc ctaggggtag actcttctgc ctactgaagt      960

gggtttgctg cacattgact ggtcaggggc agagtctggg tgctgtcctt tggccacgtg     1020

tggggacttg tctagaccag aatgaaaggg acagggtccc agacacgttt gggggtcctg     1080

attctgggct ggacacggtt gtggatccag agaagaggcc tagtctccaa taaatcttag     1140

gaattttgca ggaatatgaa aa                                              1162


<210> 2970
<211> 1725
<212> DNA
<213> Homo sapiens

<400> 2970
gaataagccc gagcagccgg tcctccagtg gctccgctcc ccgttctctg tgggctcaaa       60

atgacagagg ctcacaggac acctgcatgc ccaaggcact ccaccgtatg tgatcaacct      120

ggatccagca gtacatgaag ttccctttcc tgccaatatt gatattcgtg atactgtaaa      180

gtataaagaa gtaatgaaac aatatggact tggacccaat ggcggcatag tgacctcact      240

caatctcttt gctaccagat ttgatcaggt gatgaaattt attgagaagg cccagaacat      300

gtccaaatat gtgttgattg acacacctgg acagattgag gtattcacct ggtcagcttc      360

tgggacaatt atcactgaag cccttgcatc ctcatttcca acagttgtca tctatgtaat      420

ggacacatcg agaagtacca acccagtgac cttcatgtcc aacatgctct atgcctgcag      480

catcttatac aaaaccaagc tgcctttcat tgtggtcatg aataaaactg acatcattga      540

ccacagcttt gcagtggaat ggatgcagga ttttgaggct ttccaagatg ccttgaatca      600

agagactaca tacgtcagta acctgactcg ttcaatgagc ctggtgttag atgagtttta      660

cagctcactc agggtggtgg gtgtctctgc tgttctgggt actggattag atgaactctt      720

tgtgcaagtt accagtgctg ccgaagaata tgaaagggag tatcgtcctg aatatgaacg      780

tctgaaaaaa tcactggcca acgcagagag ccaacagcag agagaacaac tggaacgcct      840

tcgaaaagat atgggttctg tagccttgga tgcagggact gccaaagaca gcttatctcc      900

tgtgctgcac ccttctgatt tgatcctgac tcgaggaacc ttggatgaag aggatgagga      960

agcagacagc gatactgatg acattgacca cagagttaca gaggaaagcc atgaagagcc     1020

agcattccag aattttatgc aagaatcgat ggcacaatac tggaagagaa acaataaata     1080

ggagacttta gcacacttca cttgtttcta gaagtccaga attttggacc tccacgtgaa     1140

agaactgttc ttacctctga actgggggct cccataaggg ataattttcc tcagagtagc     1200

aaagtttctc ttattagaga aatcttgtga ctcagatgaa gtcagggata gaagaccctt     1260

ggacctggca ggttaatgct gattattcct tggcctttcc cttgtattta tgcaaggaag     1320

gatatactga gctgatactc ttccaagcct acaacttcaa gttttatcat ttgaactcaa     1380

gtacttttgc tgctgaggaa tggaatcaaa agaacgtagt ctcctggtga ccacctcaga     1440

tctctattat taggctagat gtatagcctc tactccccca gcttcttgct cttgaccctg     1500

cactgtaagt tgcccttcta ttagcagcca aggaaaaggg aaacatgagc ttatccagaa     1560

cggtggcaga gtctccttgg caatcaacca acgttgctat gaaatatgcc tcacactgta     1620

tagctcatta taggacgtca ggtttgttga aaaaagtggg caagacatga ttaatgaatc     1680

agaatcctgt ttcattggtg acttggataa agacttttta atttt                     1725


<210> 2971
<211> 4054
<212> DNA
<213> Homo sapiens

<400> 2971
actgcctttc caggatttat tgcgaggatg gagggaggcg caggcgttct cattcatagt       60

tctcccatcc tgaaagttct gttcctcttt tgtccagaaa ctgggccctc gtcagactgc      120

cttgccctgt tcctgactca ggccaaggcc tgcagccggg aagaggttgg ggcggcgtga      180

gttatgtgaa aagcgctcag aatacagtat gtcatgtaag aagctgaaag tgtatttatg      240

gagctagagg acaatgctgt ccttccctgg cacaagtggg cgtccgaagt tggatttttc      300

aaaaagaaga ccccggccag taaaaagtca ccaaataaca aaaccccaaa acttctgcag      360

cgcttggcac atcttgttta ttcagtaagc tttagggatt aaaaggtgga ctcccattat      420

tgtcccagtt gtttagaaaa tatgccatcg gctgaagcca aactaaaaaa gaatagatgt      480

gccaattgtt ttgactgtcc tggctgcatg cacaccctct ctactcgggc cacgagcatc      540

tccacacagc ttccagatga cccagccaag accaccatga agaaagccta ttacctggca      600

tgtggatttt gtcgctggac gtctagagat gtgggcatgg cagacaaatc tgtagctagt      660

ggcggttggc aggaacctga aaatcctcac acacaacgga tgaacaaatt gattgaatat      720

taccagcagc ttgctcagaa agagaaggtt gagcgagatc gcaagaaact ggcacgacgt      780

agaaactata tgcctctggc tttttcggac aaatatggtc ttggaaccag gcttcagcga      840

ccacgagctg gtgcatccat cagtaccctt gccggacttt cccttaaaga aggagaggat      900

cagaaagaga taaagattga gccagctcag gctgtggatg aagtggaacc tctacctgaa      960

gactattata caagaccagt aaatttaaca gaggtaacaa cccttcagca gcgtctgtta     1020

cagcctgact tccagccagt ctgtgcttca cagctctatc ctcgccacaa acatcttctg     1080

atcaaacggt ccctgcgctg ccgtaaatgt gaacataatt tgagcaagcc agaatttaac     1140

ccaacgtcaa tcaaattcaa aatccagctg gtcgctgtca attatattcc agaagtgaga     1200

atcatgtcaa ttcccaacct tcgctacatg aaggagagcc aggtcctcct gactcttaca     1260

aatccagttg agaacctcac ccatgtgact ctcttcgagt gtgaggaggg ggaccctgat     1320

gatatcaaca gcactgctaa ggtggtggtg cctcccaaag agctcgtttt agctggcaag     1380

gatgcagcag cagagtacga tgagttggca gaacctcaag actttcagga cgatcctgac     1440

attatagcct tcagaaaggc caacaaagtg ggtattttca tcaaagttac accacagcgt     1500

gaggagggtg aagtgaccgt gtgcttcaag atgaagcatg attttaaaaa cctggcagcc     1560

cccattcgcc ccattgaaga aagtgaccag ggaacagaag tcatctggct cacccagcat     1620

gtggaactta gcttgggccc acttcttcct taaaaggttc cactggaggg cagatcccaa     1680

aggacagtat caccgtaaac ctgcgttaaa atgtggaagc tgctgcttca ttaggccttg     1740

tttataacga tgtacccatg cactacggaa ttctattgct aagaaagtgg gagcataggc     1800

aaggcattgg gaacacaggg tagctgctgt tgctcttgct ctcacccctg ttgacaccag     1860

taagtctgtg tctccctcac tgaaccctgc acgttgagta acagcagcat aattccatcc     1920

taggaaaggg gatgggtgtt ccttggaatg gcattgtatt taccacctga gaaactctgt     1980

actgtctctt gatctgatct cactaaggat cacaatgtca cagatgaaac ttaaatgata     2040

acccaaaggt agacctgctg ttaatgatcc agcattggtc acaatgtacc aactgctttc     2100

tgcattccgt taaatatcat ctaacagtct aaaacatatc ccttcattgc cataatggct     2160

gccattttgc catagatttc catataactg aaaaactgaa ttgtcacttt atctttagta     2220

tcatgatgat tggaaaaacc tgtgaagttg ttaaggcact ctcatttgcc ctctttttct     2280

aagtgaatac aggacacgta ttagttgttc ttaatttttt tcccagtaaa atatggatct     2340

tttaagaaga atttgagaag caaacaatta catgtcatgt caagggggta gcagattcca     2400

ttcgttttca atattgccac aatacccagg gattaatgct gccacagggg ggcaatcttt     2460

atttgtctta cttcctaccc cttccctgtt ctgcctcttt aactcagtta agttgttctg     2520

tttgggacct ggaaaagaac ccaaagaaaa cctgagtgga caggttcatt tctggaatgc     2580

agaaaacatt ttaaaggcta gatttttaga atattctcaa ctagcattct ttccattgat     2640

ttgaagggga aattaactat tataatctct tgaatccaaa actggatatt aagaactttc     2700

ccccttacta agtttaagac ttttgtcatg tggtgagtca aataagacca ttttgattgt     2760

aaaccataaa atagttcagc aagtagccca cagttctggc ctaacagcag acttgctgtt     2820

ttcacttggt atcctggagt tgggttgcta accttaattt ctatgatgtt ttctaaaatg     2880

aaacttgata aagtagacca ccagctgcac cgtgttttct gtaaaagtat tgttagtaag     2940

tggccaagag acttgaggaa aatacagatt ttttgtttac cttggtcttg ttttaagtct     3000

taaaaaatta aagataacat tataatgtag aatacagatg ggacatagtc cttgtaagct     3060

tcccttgaaa atgttttaaa tatttaggaa gcttttaaaa gacactaaat tgtactctaa     3120

aagacactaa attgtactaa ttgtacaaag gtcaagccaa ttttatgaaa cagtcctaca     3180

gagtaatata tgtgatgcag tgtaagaagg aaaatactca tctctaacat tatggtaata     3240

acatttagcc tcttaggagt tggagcaggg ggatgggtaa ttacagattt gcagactata     3300

gaaagagttt catttttttg tgaccccaca gagtctcaaa tttttatttc actacctgct     3360

agagcctact gtgaaatcac tgctccatat ttgccagtgg aggaaatggg catagagtag     3420

agaatagctt catatgttta cacgtttgca tagactacac acatgtcatg cgtttatggc     3480

aggtagctgg tatttattcc ccaaagtaat aatgttgaag tatgggtctc atcattccca     3540

tacacagaaa cacaaaacac tttgatcata aacttttttc ttcagaagcc aaactaactt     3600

gcagaataat agagccactg gtttaatgtt tcctcaagat aggttttagt gtaagctagt     3660

attctgtgtg ttcgtagaaa tgattcaata cctgcagctg gtgaattagg aattgtattt     3720

gttgcctttt ttatattaga tgaggtgcaa aaattttaat gctagtcagt atgcaccacc     3780

acaggaaagt tagatcccat tagcacttga aactacagct ttggaaactt aggctaagtt     3840

aatttggatt tgttacttga ttcacctact gaccttttct tttgtttgaa gtgcttatca     3900

gcataatgag ctaagtgtca tgcatatttg tgaagaaaca ccctttttgg tcccttttgg     3960

gacagagagg tactccttga tctttatgaa tgacaggtta ctgttttgcc ttattgctta     4020

acttaatgta gtgaaataaa gcagacaaag cttg                                 4054


<210> 2972
<211> 3058
<212> DNA
<213> Homo sapiens

<400> 2972
acgtcagagg gtcgcgccgc tgcaggaacc cgctctgcct gagctaccgc gagtcgtaga       60

aaattacgta atgatagggg gccggtcaga gtgagggcac ctgaggtaca cgaaatccct      120

ccggcttgcc cacttcctcg gactttccac caatcaggag cttcctcccc agcaccaacc      180

aattgtggga gagaagtttt ctctgtgcta caagcccgga atttcattca tacccagcta      240

cgctccgaat gagggagcag aggtacagcg gccgaatgag cgggaacagt tattccacga      300

caggtgtaca tcagacgcat tgcttaggcc tcttatttta cgttctccaa gcaactccat      360

aagacaactg tctcggaaag gctacagtga tgacagaccg acttaagttc ggattcggct      420

tccaccgctt cttagtggta tgcaaagaag ccttttcacc ctgatgtcct tagagataat      480

atggatcagt ccagagttct cctctgggtg aaagcagaac cctttatagt gggtgccttg      540

caggtccccc ctccatccaa gtttagtctt cactatctca ggaagatatc cacctatgtg      600

caaatccggg ccacagaagg agcttacccg cgcctctact ggtctacatg gaggcacatc      660

gcttgtggga agctgcagtt ggccaaggac ctggcgtggc tttacttcga aatatttgat      720

agtctttcaa tgaagacacc tgaggagcgc ctggaatggt ctgaggttct gtccaactgc      780

atgtctgagg aggaagttga aaagcagaga aatcagcttt cagtggacac gctacagttt      840

ctgctcttct tatacattca acagttgaac aaggtctccc taaggacatc tttgattggc      900

gaagagtggc ccagtcccag aaacaaatct cagtctcctg acctgactga aaaatctaat      960

tgtcataata agaactggaa tgattacagt caccaagctt ttgtctatga tcatctgtct     1020

gatctcctcg agctgctttt agatccaaaa caactcactg catcatttca ttcaacccat     1080

agtagtctag tgtctcgaga agctgttgtg gcgctcagct tccttattga aggtacaata     1140

agtagagcca ggaagatcta tccacttcat gaacttgcac tgtggcaacc actgcatgca     1200

gatagtggct tctcaaagat ctctaagact ttctctttct acaaactgga aacctggttg     1260

aggtcctgtt tgactgggaa tccatttggt acatcagctt gcctcaagtc tggaaagaaa     1320

ttggcttggg ctcatcaagt tgaagggacc accaaaagag ctaagattgc ttgtaatact     1380

catgtggccc ctaggatgca ccgactggta gtgatgagcc aggtttacaa gcagacactg     1440

gctaagagct cagacactct ggcgggggca catgtaaaga ttcatcgttg caacgaatct     1500

tttatatatc tgctctctcc cttacgatct gtgacaattg agaagtgcag gaatagcatc     1560

tttgtcttgg gccctgtagg gactacactt cacctccaca gttgtgacaa tgttaaagtc     1620

attgctgttt gccatcgttt gtccatctct tctacaacag gttgcatctt tcacgttctt     1680

acgcctacac gcccacttat tctctctggg aaccagacag taacttttgc cccttttcat     1740

acacattacc caatgctaga ggaccatatg gccaggactg gccttgctac agtgcctaac     1800

tattgggata atccaatggt tgtgtgcaga gagaacagcg acacaagagt cttccagctt     1860

ttaccacctt gtgaattcta tgtatttatt attccctttg aaatggaagg ggacacaaca     1920

gagatacccg ggggtcttcc atctgtatat cagaaagcac tgggtcaaag agaacagaag     1980

atacagatct ggcagaaaac tgtgaaggag gctcatttga caaaggatca aaggaagcag     2040

ttccaggtac tggtagagaa caagttttat gaatggttga ttaatacagg acatcgccaa     2100

cagctggaca gccttgtacc ccctgcagca ggctccaaac aagcagctgg ataaggatct     2160

tacatgcaga cactgggccc tggaaataca aggataaatg gaggatggtg ctcatcttga     2220

aacttgaaac taaattggga aggtgctatt gctgcttaag agacattggg acttttctgt     2280

cttttttttt tttttttttt gaggcagagt cttgttctgt cgcccaggct ggagtgcagt     2340

ggcgcgatct cggctcactg caagctctgc ctcccgggtt cacgccattc tcctgcctca     2400

gcctcctgag tagctgggac tacaggcgcc cgccaccacg cccggccaat tttttttgta     2460

tttttagtag agacggggtt tcaccgtgtt agtcaggatg gtctcgattt cctgacctcg     2520

tgatccgccc atctcggcct cccaaagtgc tgggattaca ggcgtgagcc accgtgccca     2580

gccttctgtt ctatttaaga actttgattt ccattccatt ttcatttatt actgtttagg     2640

ccgaattttc gctaaacttc tgactttcat ataaacatat tgcttataga acatcagaag     2700

actcgtcttt gtgatgccca aatgaaaaag ttggtgaagg tagtaccatt gtatgtatgt     2760

taatattaaa gcaactgagt gtagatttgc aactatagtg tgtatcttca tttgtgtgat     2820

gaaagagttt tattctttct agagttaaat aagagtttta tagttctttg taactattta     2880

aaaggaaatt gctactcctt ttaaaaaata attggaaagg aagtatgatt tgttggtata     2940

tagacataga aatagtttta tactatattt tagtccttaa agtatggaac ttaatgaaat     3000

tgtttaaaaa aatctttatt tttcacttcc tgcttcaaat tttcaataaa caaactct       3058


<210> 2973
<211> 1294
<212> DNA
<213> Homo sapiens

<400> 2973
agtagctgca ccactagaaa gatggcggag caagagcaaa gaaaaatccc tttggttcca       60

gaaaatctcc tgaaaaagag gaaggcttat caagccctca aagccaccca ggcaaagcag      120

gcacttttgg caaagaagga gcagaagaaa ggaaaagggc tcaggtttaa gcgactggaa      180

tcattcctac atgattcctg gcggcagaaa cgtgacaagg tgcgtctcag acgactagaa      240

gtgaaacctc atgccttgga attgccagat aaacattcct tggcctttgt tgtacgcatc      300

gaaaggattg acggcgtgag tttactggtg cagagaacca ttgcaagact tcgcctaaag      360

aaaattttta gtggtgtctt tgtaaaagtc accccccaga atctaaaaat gctgcgtata      420

gtggaacctt atgtgacctg gggggaagtt tggcgtcatt tgcttggaag acctcattca      480

tgaaattgcc ttcccaggga agcatttcca ggagatctca tggttcttgt gccctttcca      540

cctctcagtg gcccgtcatg ctaccaaaaa tagagtgggc ttcctcaagg agatgggcac      600

acctggctat cggggtgaac gcatcaatca gctcatccgt cagctgaact agacccaggt      660

gaggcagggc tgaaaactgc ccttgggctg acttttgata ggccatgcct tgccacttta      720

caagttcttt ttgcatttac tagtatttaa gagtaacctt gagattggga ggaatagagg      780

aggctggtac aaatagatgg agacctgctg ggatcagtga atgcctgatt aggacatggg      840

gctatgcata gcctaagagt tataggctta aagatgtcga gtaactaaaa actgtattgc      900

tggccgggcg cggtggctca cgcctgtaat cccagcactt tgggaggcca aggcgggcag      960

accatgaggt caggagattg agaccatcct ggccaacatg gtgaaaccct gtctctacta     1020

aaaatacaaa aatgagctgg gtgtggtggc gcgtgcctgt agtcccagct actcgagagg     1080

ctaaggcagg aaaatcgctt gaacccagga ggcagagatt gcagtgagcc aagattgcac     1140

cagtgcactc cagctgggcg acagagcgag actccatctc ggaaaaaaaa aaaaaaaaac     1200

tattgctgca gtcattcaga tggaaatgag gaaagaataa tattaataac tgatttcaaa     1260

aaggacttga agatgtgaat catctatttt gctg                                 1294


<210> 2974
<211> 11198
<212> DNA
<213> Homo sapiens

<400> 2974
ggcaccgccc accggcttga atcccggcgc ctcagaggac tatgaggcgg gcgccaactg       60

cttgggccgc agggcgggag gcagcgcggg agtggggcgt tgaggggccg gcctagcttg      120

gggctctggc cttgcgtctt ccgaccgaat caccgctcct gagcccggtg cggggctgcc      180

gctatcgcct ggccgtgggt gccggagcgg ccgggttgcg actcagcgtt cttgggtggg      240

cgcgggcggc gtctccgcgg cgggcatccc ccgaggccgc cctcgggcca tgatcgactc      300

cgtgaagctg cgccgcgaca gcgcggcgga cttcttctcc cactacgagt acctgtgcgc      360

gctgcagaac tcggtgccgc tgcccgccgt gcgcgcctgt ctccgggagg gcgtgctgga      420

tttcaacgcc gaccgcctcc gcggggtgga ctgggcgcct ctgctgagca ccctcaagat      480

caataaagac ctgcccttgg tctccatcaa gagcttcttc cagccctggc tgggggacac      540

aggttctgac atgaataaat tttgcagaag tcgtgttcct gcgataagat acaaagatgt      600

gaccttccag ttgtgtaaag ctcttaaagg ctgtttaagt atatcaagtg tgctaaagaa      660

cctggagcta aatggactaa ttctgagaga gagggattta actattctag caaagggatt      720

gaataaatcg gcttctttgg tgcacctgtc tcttgcaaat tgtccaattg gagatggagg      780

tttagaaatt atttgtcaag gtataaagag ctctatcact cttaagacag tcaacttcac      840

aggatgtaat ctgacatggc agggagcaga tcacatggcc aagatcttaa agtatcagac      900

catgagaagg catgaagaaa cctgggctga gagtcttcgc tataggagac ctgatcttga      960

ctgtatggct ggcttaagac gtatcacact gaattgcaac acacttattg gtgacctagg     1020

tgcatgtgct tttgcagact ctctcagtga ggatttatgg ctgagagctc ttgacctgca     1080

acagtgcggc ctcaccaatg aaggagcaaa ggctttgcta gaggcccttg aaaccaatac     1140

aactctggtc gttctggata taagaaaaaa tccactcatt gatcattcta tgatgaaagc     1200

agttatcaaa aaagtcctcc agaatggaag gagtgccaaa tcagagtacc agtggataac     1260

ttctccatca gtgaaggaac catccaaaac tgctaaacag aaaaggagaa ctataattct     1320

aggaagtggt cacaaaggaa aagctactat tagaattgga ttggctacaa agaaacctgt     1380

aagtagtggc agaaaacact cccttggtaa agaatattat gcgcccgcac ctcttccacc     1440

tggtgtgtct ggtttcttgc cgtggcgtac tgcagaacgt gcaaaaagac acaggggttt     1500

cccattaatc aaaacacgtg atatatgtaa tcagttgcag caaccaggtt ttcctgtgac     1560

tgtgacagta gagagtcctt catcctctga agttgaagag gttgatgatt cttcagagag     1620

tgttcatgaa gtgcctgaga aaactagtat agaacaagaa gcattacagg aaaaactgga     1680

ggagtgccta aagcagttaa aggaagaaag agtgataagg cttaaggttg ataaacgagt     1740

cagtgagctg gaacatgaaa atgcccagtt aagaaatata aatttctctt tgtctgaagc     1800

ccttcatgca cagtcattga caaatatgat cctggatgat gaaggtgttt tgggcagcat     1860

tgagaattct tttcagaagt ttcatgcttt cttggatctc cttaaagatg ctgggcttgg     1920

gcagcttgcc acaatggctg ggatagatca gtcagatttt caattactag gtcatcccca     1980

gatgacttct actgttagta atccacctaa agaagaaaag aaggcgcttg aagatgaaaa     2040

accagaaccg aagcagaatg ccctagggca aatgcaaaat atccagtttc agaaaattac     2100

aggtgatgct agaattcctt tgcctctcga ctcctttcct gtcccagttt ctactccaga     2160

gggcttagga acttccagca acaacctagg agtcccagct actgagcagc ggcaggagtc     2220

ttttgaagga ttcattgcta gaatgtgttc tccttcacca gatgcgactt ctggaactgg     2280

aagtcaaaga aaagaagagg agttgtccag aaatagcaga tcttcttcag agaaaaagac     2340

caaaacagaa tcccattgaa atgactggag aaatattaaa ataaaaataa tagcagagtt     2400

ggaaaaccag aaatttgaac agtgaaattt ctggaagata agaagcagat gatttaagta     2460

ccagttaatt aaaggatgga acagctaagc cattccactc atctttggag catctgattc     2520

tggagtttgc caccaggcta agaaagcagc tatctgaagt gggagctctg acccaagaaa     2580

tgctgggatc ggagaataag ggaattatcc aaaatggctc cgaagaggaa ctgaagttaa     2640

gctgcccaca tgatctctct aactatgatg acctgccact tccgtttata atcaccatat     2700

aagtgcctgt aatcatttgt gttcattaaa agtgaaccag aattcccatt tggatgaaaa     2760

aataacactt ccaactttaa tcttaggccc tcatttataa atatggacaa ccaagaatca     2820

tcaaatttga agaaaaccag taacataaaa ggaggcatga aattaaaatt aacctgttca     2880

agaagatagt tactaggaga aacatgaaat ttttaaatta atgaatcaaa atcttcagca     2940

attcataaag atactgtgtt cataaagaat aggatgccat gaaaaaaata tttagagttt     3000

ctggaaatta aaaatttgat tatgaaactg aaacactcag aagatggact acacagcaga     3060

atggattcat ttgaagctta aattcatgaa atggaaggta ttaattggtc ttagacgttt     3120

catcagcaac ttaattactt agaaaaaatc tttctcagag taactaagca aaatgaacaa     3180

tgaacccatt aacgtgtggt tttgtttttt gggttttttt tttttgagtc aaggtctcac     3240

tcatgtcacc caggctgggg tgtagtgatg ggatcacagc ttattgtaac catgaaccat     3300

tgggcttaaa ttatcttccc acctcagcct cccaagtagc tgcaatgtac caccatgccg     3360

aagttttaaa aaattattgt agagttgggt tctttctttc ttttcttttt ttcttttttt     3420

cttttttttt tgagacggag tctcgctcta ttgcccaggc tggagtgcag tggtacaatc     3480

tcagctcact gcaacctcct cgatctcagc tcactgcaac cgtgaagtga tcttcctgcc     3540

tcagcccccc tagtaactgg gattacaggc acacaccacc atgcctggct aatttttgta     3600

tttttagtaa agacggggtt tcaccatgtt ggccaggctg gtctcgaact cctaacctca     3660

ggtgattcac ccacctcggc ctcccaaagt gctgggatta caggcatgag ccactgcatc     3720

cggccaagat gggttctttc ttaggctggt cttgaactcc tggcctcaaa tgatcctccc     3780

accttggcct cccaaagtgc tgagactaca gacctgagcc actgtgccca gccccatgaa     3840

agatgtttag atcaaataaa ctgataaaga tattgataaa gatatgagac aaactacttc     3900

agctttgtga cctgcaaatc cccttttata atcaccagag gtgcctgtag tcagaaaaag     3960

tctaaataaa tactaatgac atatgaaaac aaagtccaac caaagttcta ggtttgaaca     4020

tgaatggagg catggcagga cacagaaagt gaaagcttgt cctagatatt gtcttattca     4080

tgggaaggat acaggtagtg tttgattcta ggtattgatt gaaaaaatat attaaaatat     4140

atataaagtt aagggtatgt tagtaaggat aggttaggtg atgttgcatt aacagctccc     4200

aaattttaat tactttcaac aacataggtt tatttgtgcc catgcagttt gcctttggca     4260

gattggctag aggcccctat tcaacatcaa cctcaatctg gaagcgaggc tggtggaacg     4320

tcactatttg gaacattgct ggttgcagtg tccaaggaaa gacagtatga tgcagcatat     4380

attgtgactt aaagcttctg tctagatgtg acatatgtca cttctgttca catttctttg     4440

gccaaagaaa gtcacatggt tatgcctgag ttcagcagac cagggaagtg cagaattgcc     4500

atttgccatg agaagagagg gaagcaaatg tatgtcaaca actttaatag ctacaaaact     4560

acctggaaag agggaatgga atttttaggt ccaacaagac gggaaagaaa aagaaacaag     4620

ctacatagaa ataaaaaatc cacaatatag caagatcaag ttttttactc ataataaaca     4680

tgaacaggtt aaattctgga atccttaggc ttgagtaaaa acatgaaatc ccactgtgtg     4740

ctatttgcaa aatctaaaac gctgtcatag attataaaga gatgaacaaa aatataccag     4800

gcagatgcta aagagtaaat gtggctgtgt tagctgcaga ctaaatagaa cccaaggtga     4860

aaattggtaa aggggacaaa agcttctttt ggctgataag tacagtgttg cagaagattt     4920

tttaaaaaaa tatatctgca atttaaaaac ttgatgttag gccgggcgca gcggctcacg     4980

cctgtaatcc tagcactttg ggaggccgag gtgggtggat cacctgaggt cagaagttca     5040

agaccagcct ggccaacatg gcaaaactcc gtctctacta aaaatacaaa aaaaaaaaaa     5100

aaaaattagc tgggtgtcat ggcgcatgcc tgtaatccca gctactcggg aggctgaggc     5160

aggagaatcg cttgaacctg ggaggcggag tttgcagtga gctgagatgg caccgctgca     5220

ctccagcctg ggccatagag gagactccgt ctcaaacaaa caaaaacctt catcttaaaa     5280

ttatagggta agaatttaga aatacaagga aaaatggcca gccagttata acaagaagct     5340

ttaagacatc tcttttcaga atcagtggat cgactgctgc acacacacta gaatggctaa     5400

cattttgaaa tgctgataaa tatgcagagc aactggagtt cctcacagct ggtaggaatg     5460

caaaatgact cagtcactca aaacagtttg gcagattctt taaatgctaa catacacata     5520

ccatatgacc aagcagtccc actcctgggt atttagagag atgaaaactt agttcacaca     5580

aaacctgtgc gtggatattt atagcagctc cattcatagt gaccaagatg tcttccaaca     5640

ggtgaatgga tagcgatgta tccatatggt ggcaaacatg ccacaattcg gatgaatctc     5700

aacatcatat gctgagtgaa aaagccagtc tcggaaggct acattctgta tgattccatt     5760

tatatggcat tcttgaaaag acaaaactat agtgacagaa cagattggag attgccaggt     5820

gttggggttg ggaggagttg attacaaaga ggctgtacaa gggagtttgt ttgtttgttt     5880

gttttggtga tgaacagttc tgtatcctga ttgcggtggt ggtaacgtga gtctatacat     5940

atgttaaaat ttatagaact gcatactctc aaaaaaatta gttttactct ataataatat     6000

tagagcttaa aaaattcatc cctcttgccc atcagtagat caggatatga aggataccat     6060

tgaacataaa tattttgtat ccatgatgaa tacaaagtat attctcctgg aaaaccaata     6120

gaacattcat ataaatgatt cctatgaagg taaaaaactt acaaaattca aagatcatac     6180

agatcatgtg ctctgtataa tgtaataata gtaacaaaag gcctgtccac ttggaaattt     6240

ttaaatgatc ttctaaataa ctcatttaaa ggagaaatca aaataaattg caaattattt     6300

agaattaata aaaacttctc taaagctgag gaattctacc aaagaggtgt tagaggaaat     6360

tgtatagatt ttgatttact ttccaggaag aaagaagaca aaagagatga attaaacatt     6420

taaagctaag aaagagataa accaaaagaa aggtgaggaa ttggtaaaag cagaaatgaa     6480

taaaatagca aattttgatc agtgaaacac aggtttttaa aaatgaaaga taaacctttg     6540

taaaatatga taaagaaaaa aaagcaagaa gtaattaaca aaaattgcca gcattaggaa     6600

taattttaga aggataccta caactagaag agatattttt aattatgagc acttttataa     6660

tttactataa ataattgtgt agtgttaaac caataaattt gaaagactag atgaaatgtg     6720

actgtttaaa aatatggatt gtaaaaattg ataaaaaata gaaaatgtaa ataaacgaaa     6780

catcttagga gaaattgaaa aaataggaca agaacttatt tttaaaaaga ggccaggtgc     6840

ggtggcccat gcctgtaata ccagtacttt gggaggccga ggtgggcgga tcacctgaga     6900

tgaggagttc aagaccagcc tggccaacat ggtgaaaccc cgtctctact aaaaatacaa     6960

aaattagccg ggcttggtgg cgggcacttg taatcccaac tactcaggag tctgaggcat     7020

gagtgtcgct tgaacctggg aggcagaggt tgcagtgagc tgaggtcaca ccgttgcact     7080

ctagcctggg agacaagagg gaaactctgt ctccaaaaaa aaaaaaaaaa aaatacagtt     7140

agaaaaactt taaaggggcc aggtgtggtg gctcatgtct gtaatcccag cactttggga     7200

caccaaagtg ggaacattgc tgagaccagc agtttgagac cagcctgggc aagacctcat     7260

ctctacaaaa attaaaaaac aaaacaaaac aaaaaaaccc aaaacttagc caggcatggt     7320

ggtgcgtgca tgtagtccca gccactcagg aggctgaagt gggaggatcg cttgaggccg     7380

ggattcgagg ctgcagtgag ctgtgatcat gccaccactg ctctctagcc tgggcaagag     7440

tgagactccg actcaagaag agaaaaagaa aaaccttcca ggggcacatt tatttgtaaa     7500

ccattccaga ggatagaaaa gagatgtaag gctccctaat tcattccata cggttagcgt     7560

aatccttata gcaaactgca caaataaaac acaaggaaaa ctaaaccaaa ttcaattaat     7620

gtaggtgcaa aaaatccaaa ataaaactag cagtttgaat tcagcattgt agcaaaagat     7680

atatcatttt caaggaagat ttgtaccaaa acatgcaaga ttgagtgaag agtaactcac     7740

tgtagctcac taaattaaca gattaaagaa gtatagtcat cttcacaagc tgaaagagta     7800

tgtgataaat tcaacatcct ctggtattct taacaatctc gaaatagaag gaaacttcct     7860

tagcttagct tcttggcttc attaaatata cctaacagaa atccacagga aacaaacttg     7920

gtgaaaagtt tttgctaaga taaaaacggt actaaaaagt acacattttg ggaaatgaga     7980

caaggctctc gttatttgta aatatggggt cttttttttt ttggacaaaa aaccccctgt     8040

gatgatctac tggcatgcta ttacagctaa taaagctgaa taaggaggct gtgcacaaca     8100

ccaacacacc ggtatgaaaa gtgtgtacac cagcaataac caattagaaa atgtatgagg     8160

aaatagactc tcatccacaa tagctgcgag aagtaaatat tatctagaaa taagattaac     8220

aagagaaatg taaggcctat ataaataaaa ggataaatct atgctagagg gtataaaaga     8280

aacacaaaaa tagaggtatg ccatgtataa gacccaacat aataaatagt tctaccaaat     8340

taatttataa attcaaagca atttcatata accacagtaa agctttttaa atggatgtaa     8400

taacctgatt ataacattaa tctgaaagtc atcaggcata aagcaatttt gattacatct     8460

caaaacaatc catggagtta gggtaaatgt gctgttcaca caggaataat cacaggtata     8520

gaaccgagaa cctaggaaca gagcaatgta tatatatatg tatttaaaaa atggcatcac     8580

aagtcagtag agaagggttt gaactattca gtaaatgatg ttgaggttat ttactacttt     8640

ttcttatttc atatcatgga tgaaaaaaat caagatgaat taaacatgga aattaaaaat     8700

aactagaaga aaatactgga aaaaaattgt aataaatgtg taagaaaggc attcccaacc     8760

aagacacaaa acccagtagc catgaaaaaa aagatagatt tgactacatt tttaaaaagt     8820

aaaacctttc actttttaca aaactttgat aaaattagat ttcataaata aaggagtggg     8880

aaaatacatg taatagaaca gaagatttaa gataatataa agagcaccta caaacaacaa     8940

aaattggaca aaggctataa aaatatttta taaataagaa atacagacta taaacataaa     9000

ctttcaacct cgtaagcaat caggaaaatt aaagttaaaa tgagatacta tttttcaata     9060

cattgaaatg gcagattatt aaagattggt gatagtgctg gagataatgt gaggaaagga     9120

gtattctcag tcattgtaga aattgataca gcttttggat ggacagtttg acagtgtgta     9180

tcaacatgtg aaatgtctcc agcctttgat ctaatgacta attttaggca tccagcctga     9240

agaaatattc acacaagtgc ccaaagagtc agatacaaga ctgtgtgaag tgttttttga     9300

gataataaaa aactagaaac agcataaatg tacagaaatg cagaaattgt tgaattagta     9360

cataccaatt tctgacatat aacactctgc agcagataaa gacaatagct ctctagtgtg     9420

gacatgaaaa tatttctaag acattgacag gacgaagaag ttgcacagta accacgcact     9480

cctgtttaca tttgtatagt taaaacttgt ttacctatac gtagcatata tgcgtgtgtg     9540

caccctagaa aagagtctgt gataacacat atcaagctat tgacagcggt tttgtctgct     9600

gaaggaggaa aaaagggggg cttctcacat tttactccat ttaattctag gttgtttggt     9660

ttaaaaaaaa agtttttatg tacaacagac aatttttaaa attccttttc atcatagaaa     9720

atgaaaatgt gtactctgtt atcctttacg ctctgtccat ttttttcttc aaaaatgtgt     9780

ctgacctatt atcaatgtga atgaaaatga gctttgctac ataacctctt ttcagagctt     9840

tgtattcctg aagtgttgga gtcgcctaca tggcatagtc aaatgttttt aacttaacca     9900

caacccacag taaaaatgaa gctttctgca aagttaaaag tagtagtcct ggccccacct     9960

tccttgtgtg cacgtataat taatggaaaa ttgcatcaaa caactctgat tgtacttcta    10020

gtgactaatt catgttctgt tctattcctt gcctttaaag aaaattatgt tggcaactca    10080

cgaagtatgt ttcacaatcc actaatgggt aatgtcctac tgtttggaaa cactggctag    10140

agtgtttcaa acatctgctc tgtttacccc tgacaaaact gctactcgtg gggcaatgca    10200

agtctttccc acatttgttt tattttatgg ctaaaagtca tttctgcatt tgcaaattac    10260

ttccaaagcc taccttcctt gagctcttta actctctata gtcttctggt aattttcttt    10320

agatttccct tttcagaacc cttttgtgac actgaaaacc tgagttttca aactgataca    10380

tctacctgag aattttcaca tataatttgg tcaaaaagtt aaaaaataag aagactttgc    10440

cctgtgactg aggtgctcag aaggtatggc tggctgctca caaaggcaca tagtgagtga    10500

taggggctga aagggctcag agaatgcccg agttctctta gtacagtttg tacattttaa    10560

accactgtga actgaaaaaa aaaaaaaagg caaccttggt agtttagaaa tagataagga    10620

cccacttata gattaaataa taattagctt gttccagaga gaccagtgaa gattagttgg    10680

tttatttaat gtgttagaaa gatggtcctc aaagtccttg aaatgtgaag gcggctttta    10740

tctccttaag aaaacaagaa aactccacaa aatcttgaaa gctagataat cctagcttaa    10800

atgataaaat ttgagtagag tttgaaaaca ctaaaatcag tttgccaaat aaccagctct    10860

aatttcttta taccaaagcc aaacttcacc taaatcttac ctaagaattg agttccttat    10920

tgtaaccaga taggagacac ttttgtatat tattccaaat attgcaaacc tacaaggagt    10980

aaaaggtgtt attattttaa agaagaagga atgaggcctg agaggtattg attcacttgg    11040

ttgagggctt caagtagcac aaggcaaaag caggatttgt tgacttccaa acctgttttc    11100

ttccttcacc atgtggcctt tgcatctttc ccacacaaat attattccac aaatatttat    11160

tgtcaccaac tataataaaa gaacagaact atgtatca                            11198


<210> 2975
<211> 940
<212> DNA
<213> Homo sapiens

<400> 2975
gggtggcgcc cgcggcaggc ggcggccatg aacttctccg aggtattcaa gctctccagc       60

ttactctgca agttctcccc ggacggcaag tacctggctt cctgtgtcca gtaccggtta      120

gtggtccggg atgtgaacac ccttcagatc cttcagctgt acacgtgcct agaccagatc      180

cagcacatcg agtggtcggc agactcgctc ttcatcctgt gcgccatgta caagcgaggg      240

ctggtgcagg tctggtcttt agagcagccc gaatggcact gcaaaataga cgagggctca      300

gccgggctgg tggcctcgtg ctggagcccg gacgggcgcc acattctcaa caccacggaa      360

ttccatctgc ggataaccgt ctggtccttg tgcacaaaat ccgtgtctta catcaaatac      420

ccgaaagctt gtctgcaggg aatcaccttc accagggacg gccgctacat ggcgctggca      480

gaacggcgcg actgcaaaga ttacgtgagc atcttcgtct gcagtgattg gcagctcctg      540

cggcattttg atacggacac ccaggatctc acagggattg agtgggcccc aaacggctgt      600

gtgctggcag tgtgggacac ctgcttggag gtgcgcatcc ttaatcacgt gacttggaaa      660

atgatcacgg agtttgggca tcctgcagcc attaatgatc ccaagatagt ggtgtataag      720

gaggccgaga agagcccaca gctgggactg ggctgcctct ccttcccgcc gccccgggcc      780

ggggccggcc ctctcccgag ctcagagagt aaatatgaga tcgcctctgt cccagtctcc      840

ttacagacac tgaaacctgt taccgacaga gcaaacccga aaatcggcat aggaatgctg      900

gcatttagtc ctgacagcta cttcctggcg acaaggaacg                            940


<210> 2976
<211> 1224
<212> DNA
<213> Homo sapiens

<400> 2976
agtctatccc cagtgtgagc tagagagcgg accatgaagg aagtgggcag accccgggaa       60

gttagaggac gcccggggaa aagcagaatt cagaaggagc tggcggacat cactttagac      120

cctccaccta attgcagtgc tggtcccaaa ggcgataaca tctatgaatg gagatcaacc      180

attctagggc ctccaggatc cgtgtatgag ggtggtgtat tctttctcga tatcactttt      240

acaccagaat atcccttcaa gcctccaaag gttacatttc ggacaagaat ctatcattgt      300

aatattaaca gtcaaggtgt tatttgcttg gacatattga aagataattg gagtccagca      360

ctaaccattt ctaaagtcct cctttctatc tgctcacttc ttacagactg taatcctgcc      420

gaccccttgg tgggaagtat tgccactcag tatatgacca acagagcaga acatgacaga      480

atggccagac agtggaccaa gagatacgct acataaattg gggtttcaca attcttacat      540

tatttgtctg tcacagaaga gagctgctta tgattttgaa ggggtcaggg agggtgggag      600

ttggtaaaga gtagggtatt tctataacag atattattca gtcttatttc ctaagatttt      660

gttgtaactt aaggtatctt gctacagtag acagaattgg taatagcaac ttttaaaatt      720

gtcattagtt ctgcaatatt agctgaaatg tagtacagaa aagaatgtac atttagacat      780

ttgggttcag ttgcttgtag tctgtaaatt taaaacagct taatttggta caggttacac      840

atatggccat ttatgtaaag tccctctaag actacatact ttttgtttaa aacaaaattg      900

gaatttgttt tcccttcttg gaagggaaca ttgatattta acagagtttt tagagattgt      960

catctcatat atataaaatg gacacgtggc tataaaacac catataagag atgagtagtg     1020

cgttttattt tatatgccaa tctactttgt ttaaaaaagg tctgaatcag gacttgtgaa     1080

aacctgtagt gaaatacctt aagctgttaa ctaactgtaa ggcgtggaat aggagttgct     1140

cagtggattg gttctatgtt gtggactact taagtctgca tttgttactg tgctaataaa     1200

caatattaaa aaccacctaa taaa                                            1224


<210> 2977
<211> 795
<212> DNA
<213> Homo sapiens

<400> 2977
agaggccagg tgcggtggct cgcgcttaca ttcctagcac tttgggaggc caaggcgggc       60

ggatcacctg aggtcaggcg ttggagacca gcctagccaa catgatgaaa cctcgtctct      120

actaaaaata caaaaaatta gctgggcgtg gtggtgcgtg cttgtagtcc cagacactcc      180

ggaggtgagg cgggagaatc gcttgagccc gggaggtgga ggttgcagta agccaacacc      240

gtgccactgc actacagcct gggcgacagg ctgataggaa gatgtcttca ggaaatgcta      300

aaattgggca ccctgccccc aacttcaaag ccacagctgt tatgccagat ggtcagttta      360

aagatatcag cctgtctgac tacaaaggaa aatatgttgt gttcttcttt taccctcttg      420

acttcacctt tgtgtgcccc acggagatca ttgctttcag tgatagggca gaagaattta      480

agaaactcaa ctgccaagtg attggtgctt ctgtggattc tcacttctgt catctagcat      540

gggtcaatac acctaagaaa caaggaggac tgggacccat gaacattcct ttggtatcag      600

acccgaagcg caccattgct caggattatg gggtcttaaa ggctgatgaa ggcatctcgt      660

tcaggggcct ttttatcatt gatgataagg gtattcttcg gcagatcact gtaaatgacc      720

tccctgttgg ccgctctgtg gatgagactt tgagactagt tcaggccttc cagttcactg      780

acaaacatgg ggaag                                                       795


<210> 2978
<211> 962
<212> DNA
<213> Homo sapiens

<400> 2978
ggcctcgacc ctatgctttg attcgcgtgg cgcaggcgcc tactgccccg ccggcggggc       60

ccgggcttcc tgccgcggga tgttctcccg aaggagccac ggggatgtga agaagtccac      120

ccagaaggtg ctggacccga agaaggacgt gctgacccgc ctgaagcacc tgcgggcgct      180

gctggaaaat actgcagttt ctacctgaac gaattttctt tcgatggcat taccagagta      240

taggctcaac tttaaagaag cttctacaca ctggaaattc tattaagata agatgtgaag      300

gaatcaggct gtttcttctg tggcttcaag cacttcagac aaactgtgca gaagagcagg      360

ttctgatttt tgcttgcctg gtgcctggtt tcccagcagt catgtcatcc aggggccctt      420

gcacactgga gacactcatc aatcccagcc ctagtgtagc tgatgtaaag atatatccag      480

aagaaatcac tccactccta ccagccatat caggggagaa gattgctgag gaccaaacct      540

gcttttttct tcaaatactg ttgaagtata tggttattca ggctgcgagc ttggagtgga      600

agaataagga gaatcaagat actggtttta aatttctttt tacattgttt cgaaagtatt      660

atcttcctca tttatttcca tcatttacta agttaacaaa catctacaaa cctgtacttg      720

acatccccca tttgagacca aagcctgtgt acattactac cactcgagac aatgagaaca      780

tttacagtac aaagattcca tatatggcag ctcgtgttgt ttttattaag tggattgtaa      840

ccttcttttt ggaaaaaaag tatctaactg caacacaaaa cactaaaaat ggagttgatg      900

tattgcctaa aatcatccag gtatgccatc catcatcttt ttatctgtta atgcttgtgt      960

aa                                                                     962


<210> 2979
<211> 1947
<212> DNA
<213> Homo sapiens

<400> 2979
gagcgacgcg tacgtctacc tgcctgcctt acagggcacc taggagggac cccttcctgg       60

cccatccgcg ccgcgcaggc gcacgcccac gcagcgccta gacgcccgag ccgagcgtcc      120

cgtctcctag taaccagccg ctagccccct tttccacgac tcatttctta atctctgcct      180

gaggctgccg cacctggatg gaacgcgcat gcgcaaggct gtctctcgca gccccgcctt      240

ccctcagctt gaaacacctg ctgcttcgcg gcggtggctt tgtgccactt ttcccagggc      300

ttgggcatca ttctggaccc atgttcggtg aaccggttac tctcagagct gctttcgggc      360

gcagctcctg ctgcagccag ggcccgtttt aagagaggct tccaggtcca gccctcccgc      420

tgcagcctgc agggagcgag ccggcctgtc ccgatgacat agacactagg tttttacagc      480

aattctctga tgaccttgat atggtagaac gctgtgtatt tcaagagtaa gctctcgttt      540

gaggagacta acaattcctg ttttcgccag atttcttctt gaatggcaac ctaaatgcca      600

gtccaaagag gcccccaata gacttgttca cccttcatgt cctcaactct ggggaagtta      660

agtaatcaag ttgaagaaac acttccacta cttaaaaagc ctctaaagag agcaatcact      720

acacttatgg ctgggatttt gcgcttagta gttcaatggc ccccaggcag actacagact      780

gtgacaaaag gtgtggagtc tcttatttgt acagattgga ttcgtcacaa attcaccaga      840

tcaagaattc cagaaaaagt gtttcaggcc tcacctgaag atcatgaaaa atacggtggg      900

gatccacaga accctcataa actgcatatt gttaccagaa taaaaagtac aagaagacgt      960

ccatattggg aaaaagatat aataaagatg cttggattag aaaaagcaca tacccctcaa     1020

gttcacaaga atatcccttc agtgaatgca aaattgaaag tagttaagca tttgataaga     1080

atcaagccct tgaagttgcc acaaggactt ccagcagagg agaacatgtc taacacgtgc     1140

ctcaaaagca ctggggagtt agtagtgcag tggcatctga aacctgtgga gcagaaagca     1200

catgagtcct aatgccccag cagcttccga ttggaaaatg caaattgttt ttatttaaag     1260

atgacggagt cttgctctgt cacccaggat ggagtgtaat gccacggttt cagcttactg     1320

caatctctct gcctcctggc ttcaagcatt tctcctgcct cagcctcccg agtagctggg     1380

accacagaaa ccacaacaaa ggtgcttgcc catggctcct cgcttccctc tgcctcatga     1440

ctgatgccaa ttattcccct tgtggccccc tgtggtgtga catgtactcc ctctccgggg     1500

atccgaaatg aaaccaattt ctacaacata ggaatgattt cggcatgtct aggagagtca     1560

gagaaaagac gggagggaaa tgggggagaa agaaaaacgt gagagaacct tctacttcct     1620

gaaaggcacc atgactctgg aatgttacct gtaattaaga atgtcagaag aaccgagcct     1680

ccattctaaa gtttctgtgg tgaagtcatc tgtatttcct aggaaacttg aagaggaaca     1740

aactgaaact tgacaaaact cggaagagac ttacaagaat cagaagtgca cacatggtgc     1800

catatttgga agtcatgaag aaaaactgaa cagcattacc gaggaaaaac ttcttactcc     1860

taaatatgca acgctgtcag taagaagcac attaaggcta agggttacta ataatattta     1920

aataaatgtg gccattatgc ttctagg                                         1947


<210> 2980
<211> 1476
<212> DNA
<213> Homo sapiens

<400> 2980
gaaagagcag aagaggaggt ggggtggagg gagcagagcc agggattagg ggactactga       60

ggctctggag atgagaccgc caggagtcct tccccaccat gagccccctc cactcctgca      120

gctggaggag tttttcccag tctcagtgct gccctggggc gagagagact gaacaagctg      180

tttgggtggg aagagaatgg aggaagttga cagggatggg cggggcccgt gggggggctg      240

accaggaacc cagcttcctg ctcagtaccc aggcatccag cccccagctc acccccaccc      300

cttccagccc ccactcccct caggaaccca aggttccagc cctcctccca aatcccagcc      360

acccctcccc caccagtttc tcccctctag gggatggagg ctgagagacc ccaggaagaa      420

gaggatggtg agcagggccc ccctcaggat gaggaaggct ggccccctcc aaactccacc      480

actcggcctt ggcgatctgc tcctccatcc cctcctcctc cagggacccg ccacacagcc      540

ctgggacccc gctcggcctc cctgctctcc ctgcagactg aactccttct ggacctggtg      600

gctgaagccc agtcccgccg cctggaggag cagagggcca ccttctacac cccccaaaac      660

ccctcaagcc tagcccctgc cccactccgt cctctcgagg acagagaaca gctttacagc      720

actatcctca gtcaccagtg ccagcggatg gaagcccagc ggtcagagcc tcccctccct      780

ccaggggggc aagagctcct ggagttgctg ctgagagttc agggtggggg tcgaatggag      840

gagcaaaggt cccggccccc cacacacacc tgctgagact tgagccccaa ccagcccttc      900

cttgccactg gtctcaaagc tgggcagccc attgcatgcc ctcaactctt gcttggcagg      960

ggtaccagag actgaaagac acggcacaaa tctcaatatt catctcccac atcaccttcc     1020

ctgggaactg gacagggtga aagtcctcaa actctgggaa caggcgagat ggaacaggga     1080

tttaactccc cgcccacagg tccatgggag cttgaggcag taagggggat cccaggcacc     1140

catctcaagg agtggctggg agtcttttcc ctaacttgtg gggacaccac cagttgtcaa     1200

gctactaggc agtagggtct gagggctcag gcctccacct gagaggttat aacctgagag     1260

acagctctac ccttcctccc agtaagaagg gaaggtgggt gggcacctga gagattaaga     1320

ctattctccc agtcccacta ccagcacccc cgatccctga gactgagggg tttacgggct     1380

gtgaatggac cttcagccct gcccaccctc cctccccact gctgctgagt ctgtctgatg     1440

ttttggttgt gtgaataaat ataattcccc tctgga                               1476


<210> 2981
<211> 380
<212> DNA
<213> Homo sapiens

<400> 2981
accttcctgg agcagtcgaa aacccgattt aacaagaact acaaggggat gagtctatcc       60

aaaatcacca ccaccgtggg cctaaacatc ggcactgtgg atgtgggaaa ggctcggctc      120

atgttctggg acttaggagg gcaggaagag ctgcagtctt tgtgggacaa ggacaagaca      180

aagtgtgggg acctggggac cctgcactcc tccaaagtga gtgcctcctt tcggctcaga      240

gaccttgctg ctgaccacca caggacacag aaatggcaaa gaccagatgt ggggacggca      300

ggatggctgc ctctcccctg atgaggttcc ttcagttcta gcttaacatt tgttcttcca      360

tgatcaccag aagactcctc                                                  380


<210> 2982
<211> 2240
<212> DNA
<213> Homo sapiens

<400> 2982
cttccgagtt accgccgccg tcgccgccgc tcctcctctc ccggtcctgg gtttccttgg       60

cgctgcggcc gccgctccct ctgcgacctg tatgaggagg aggaggagga ggatgtgaag      120

atggcggagc tgcagatgct gctggaagag gaaatcccgg ggggccgccg ggccctcttc      180

gacagctaca caaatctgga acgggtggcc gattactgcg agaacaacta catacagtca      240

gcagataagc agagagccct agaagaaacc aaagcctaca ccacccaatc cttagcaagt      300

gttgcctatc tgataaacac cttggccaac aatgtcctgc agatgctgga tatccaggca      360

tcccagctac gaaggatgga atcttcaatc aatcatattt cacaaacagt tgatattcat      420

aaagagaaag ttgcaagaag agaaattggt attttgacta ccaataaaaa cacttcaagg      480

acacataaga ttattgctcc agccaacctt gaacgaccag ttcgttatat tagaaaacct      540

attgactata caattctaga tgatattgga catggagtaa aggtgagtac ccagaacatg      600

aagatgggtg ggctgccgcg tacaacacct ccaactcaga agccccctag tccccctatg      660

tcagggaaag ggacacttgg gcggcactcc ccctatcgca cactggagcc agtgcgtcct      720

ccagtggtac caaatgatta cgtacctagc ccaacccgta atatggctcc ctcgcagcag      780

agccctgtga ggacagcttc tgtgaatcaa agaaatcgaa cttacagcag cagtgggagt      840

agtggaggga gccacccaag tagtcggagc agcagtcgag agaacagtgg aagtggtagt      900

gtgggggttc ctattgctgt tcctactcca tctcctccca gtgtctttcc agcccctgct      960

ggctctgctg gcactcctcc ccttcctgct acttctgcat ctgcccctgc tcctcttgtt     1020

cctgctactg tcccttcctc cactgcccca gacgctgctg ctgggggtgc ccagaccctt     1080

gctgatggct tcacttctcc aactccccct gttgtttctt ccactccccc tacaggtcat     1140

cctgtacagt tctacagcat gaataggcct gcctctcgcc atactccccc aacaataggg     1200

ggctcgttgc cctatagacg ccctccttcc attacttcac aaacaagcct tcagaatcag     1260

atgaatggag gaccttttta tagccagaat ccagtttcag atacaccacc tccaccgcca     1320

cctgtggaag aaccagtctt tgatgagtct cccccacctc ctcctcctcc agaagattac     1380

gaagaggagg aagctgctgt ggttgagtat agtgatcctt atgctgaaga ggacccaccg     1440

tgggctccac gttcttactt ggaaaaggtt gtggcaattt atgactatac aaaagacaag     1500

gaagatgagc tgtcctttca ggaaggagcc attatttatg tcatcaagaa gaatgacgat     1560

ggttggtatg agggagttat gaatggagtg actgggcttt ttcctgggaa ttacgttgag     1620

tctatcatgc attattctga gtaaagctca gcagggctgt gcttgcctca caggaatagt     1680

caggtcttcc cagattatct gaaggccctg gggattccac tccagtaaag tagaatgaag     1740

gatacaaatg ataaaaatta cacttttttt tttggtttat tccccagtat taaaaacaaa     1800

gcaagctgag tctgaacaaa tggatctttc tgccatcatt tgtacaatgc tgagctgtct     1860

ggattgaaat aaaatgacca tttttatgta tgtcaaaggt ataacagcat aactgtgtag     1920

ccaaaacaaa atcagattaa gactgattca gaaaaatctg ggatctttct caggaatact     1980

gtataccctt gggatttctc ctcctgcaga atctgtggca ttggatgttc ttcattgcct     2040

gtgctaaggg gttaacctca tggcccagtg ggtaccctag ccccttcttt tcttccactt     2100

gtatgaagag gagggaacca acatttaaat accacactta accattttta caattatttc     2160

agatggcttt tttcctctgt gacactgtaa attctgcatt ctctcagcac ttgagtgcac     2220

caaacgagtg aatgctgaac                                                 2240


<210> 2983
<211> 588
<212> DNA
<213> Homo sapiens

<400> 2983
agcgtggagc cggtgccgag ccggggcgaa gctggatccc ctagatagac tgtcttcaag       60

ctcactgata ttttcctctg cttgatccat tgtgctgttg agagcctcta gtaaattttt      120

cagatgctgc catgaaagca ggcccacctt tccttactgg agaatatttt gtgaatttga      180

tttagaaaac tgacagactt caaggatgca gctgctacta ccggaggtgt gtggcacctt      240

acctcagcaa ggccatgaga ccgtgtggcc atgatgtggg cccctcatgg cctcagcagg      300

aacacagcac tatagtattg gcctccgcca gaaaaacagc ttcaagcaga gtggtccctc      360

aggcacagta cctgccacgc cacctgagaa accctcggag ggcagagtct ggcctcaggc      420

ccatcagcaa gtgaagccaa tctggaagct ggaaaagaag caagtggaga cactgtcagc      480

agggttgggc ccaggcctct tgggcgtccc accccagcca gcatatttct tttgccccag      540

cactttatgt agctctggga ccacggctgt cattgcaggc cacagcag                   588


<210> 2984
<211> 1398
<212> DNA
<213> Homo sapiens

<400> 2984
gacacaggaa actcccctga aacctgtttc tcagcttccc ggcccagctg gggcacccac       60

tggaaggaga ggccaggcgg aagaccctgg ctccgtcatg gcctctgccc tgaggccacc      120

ccgtgtcccc aagcctaagg gtgtcctgcc ttcacactac tatgagagct ttctagagaa      180

gaaggggccc tgtgaccggg attacaagaa gttctgggca ggcctgcagg gtctcaccat      240

ttatttctac aatagcaatc gggacttcca gcacgtggag aagctcaact tgggagcatt      300

tgagaaactc acagatgaga ttccctgggg aagctcacgt gaccctggca cccacttcag      360

cctgattctc cgggatcagg agatcaagtt caaggtagag accttggagt gtcgggaaat      420

gtggaaaggc ttcatcttaa cggtggtgga gctccgtgtc ccgaccgact tgaccctgct      480

tcctgggcac ctatacatga tgtctgaagt cttggccaaa gaggaggcgc gccgtgcact      540

ggagacaccc tcgtgcttcc tgaaggtgag ccggctggag gcacaactgc tcctggagcg      600

ctaccccgag tgcgggaacc tgctgctgcg gcccagcggg gacggcgccg acggcgtgtc      660

ggtcaccacg cggcagatgc acaacgggac gcacgtggtc cggcattaca aggtgaagcg      720

ggagggcccc aagtacgtga tcgatgtgga acagccgttc tcttgcacct ccctggacgc      780

cgtggtcaac tatttcgtgt cgcataccaa aaaggcgctg gtgccattcc tgttagacga      840

ggactacgag aaggtgctag gctacgtgga agccgataag gagaatggcg agaatgtgtg      900

ggtggcgccc tccgctccgg gcccaggtcc tgcaccctgc acaggtggcc ccaagccgct      960

gtcacctgcg tctagccagg acaagctgcc cccactgccc ccactaccga accaggaaga     1020

gaactacgtg acccccattg gagatggccc agctgttgac tatgagaacc aagatgtggc     1080

ttcctctagt tggccagtca tcctgaagcc aaagaagttg ccaaagcctc ctgccaagct     1140

tccaaagcca cccgttggac ccaagccaga gcccaaagtc tttaatggtg gcttgggcag     1200

gaagctgcca gtcagttcag cccagcctct cttccccaca gccgggctgg cagacatgac     1260

ggcagagcta cagaagaagc tggagaagag gcgggcactg gagcactgat tcggacacac     1320

cagggaccag cgggctagtc ccagggcatg gcccagcggc cagattcttt ttcccaggat     1380

taaaactctg accccagg                                                   1398


<210> 2985
<211> 1678
<212> DNA
<213> Homo sapiens

<400> 2985
gcggcgagcc gcgagccagg cagtccgggg catccagact gcaggccgcg cccaggccgc       60

gcccaggctg cgccgcccgc ctgcctcccg cgctgccgcg tcgccagtgc tagcgctcct      120

ctccagcatg ctgcggcggg gcagccaggc gctccggcgc ttctccactg gccgggttta      180

tttcaaaaac aagctgaagt tggcactaat tggccagagc ctctttggac aagaagtcta      240

tagccacctc cgcaaagagg gccaccgagt agtaggggtg ttcacagttc cagacaagga      300

tggaaaagct gaccctctgg ctttggctgc agagaaagat gggacccctg tgttcaagct      360

tcctaaatgg agggtcaagg gcaagaccat caaagaagtg gcagaagcct acagatccgt      420

gggtgcagag ctaaatgtgc tccctttctg cactcagttc attcccatgg atataattga      480

tagtccaaag cacggctcta tcatttatca cccatccatc ctgcccaggc acagaggagc      540

ctctgctatc aattggactc taattatggg agataagaaa gctgggtttt ctgttttctg      600

ggctgatgat ggcttggata caggacccat ccttcttcag agatcatgtg atgttgaacc      660

caatgataca gtggatgcac tttataatcg gtttcttttt cctgaaggaa tcaaggccat      720

ggtagaagct gtccaactca tagctgatgg aaaagctcct cgtatacccc agccagaaga      780

aggggcaaca tatgaaggta tccagaaaaa ggaaaatgct gagatttctt gggaccagtc      840

tgccgaagtt ttacataact ggattcgagg tcatgataaa gtccctggag cttggacaga      900

gataaatgga cagatggtca ctttctatgg ctcgacatta ctgaatagct ctgtgcctcc      960

tggagaacca ctggaaatta aaggtgccaa gaagcctggt ctcgttacca aaaatggact     1020

tgttcttttt ggtaacgatg gaaaagcact gacggtgaga aatctgcagt ttgaagatgg     1080

aaaaatgatc cctgcctctc agtacttttc aacgggtgag acgtcagtgg tagaactgac     1140

agctgaagag gtgaaagtgg cagagaccat caaggtcatc tgggctggaa ttttaagcaa     1200

tgtccccatt attgaagact caacagactt ctttaaatct ggagcaagct caatggatgt     1260

tgccaggctg gttgaagaga tcagacagaa atgtggtggg cttcagttgc agaatgaaga     1320

tgtctatatg gccaccaagt ttgaaggctt tatccaaaag gtcgtgagga aactgagagg     1380

agaagatcaa gaggtggagc tggttgtaga ttatatttca aaggaggtca atgaaatcat     1440

ggtaaaaatg ccataccagt gtttcataaa tggacagttc acagatgcag acgatggaaa     1500

gacttacgac actatcaacc caacagatgg atctacaata tgcaaagtat cctacgcttc     1560

tttggcggat gttgataaag cagtagcagc agcaaaagat gcttttgaaa acggtgaatg     1620

gggaagaatg aatgcaagag aaagaggaag attgatgtat agcatgagaa tgaactaa       1678


<210> 2986
<211> 4666
<212> DNA
<213> Homo sapiens

<400> 2986
tggcagcttg ttttgccttc acgggagtag aaggaggcgg cgtccggccg cggccgacgg       60

tagttcgctt ccccgagagt gcgcggaggc ccgggtgcga ggagggcctg tttctcttca      120

gccctggttc attcacctcg cggaccgagg gccccgccgt caggagccgg cgaccgtgcc      180

ctggtgcgag ctgtgatggt cattgtcctc cagagcagtg atggaggaaa taccagccca      240

ggaagcagca gggtcaccaa gggtccagtt tcagtctttg gagacccagt ctgagtgtct      300

gtccccagag cctcagtttg tgcaggacac cgacatggaa cagggactca ctgggggatt      360

tccaatttcc aagcctgatg ggatctccca gctggaacag gatctacagg tctttgatct      420

ggaaactaag actagagaag tcttaagaga tgactgctca gatggagaga ccagagaaga      480

gaacaagctg ttgattccta agcagaaaat ttcggaagaa gtgcattcat acaaagtgag      540

agtaggaaga ctcaaacacg atattaccca agttcctgag actagagaag tgtataagtc      600

tgaggacaga ttagaaagac ttcaggaaat tctaaggaaa tttctgtacc tggagagaga      660

gtttaggcaa ataacaatca gcaaggaaac cttcaccagt gagaagaaca atgaatgtca      720

tgaacccgaa aaaagcttca gtctggactc tactattgat gcagatcaga gagttcttag      780

aatacagaat accgatgaca atgataagta tgacatgagc ttcaaccaga attcagcctc      840

tggtaaacat gaacacttaa atctaacaga ggattttcag agtagtgaat gtaaggaaag      900

cttaatggat ctctcccacc ttaataaatg ggagagcatc cctaacactg agaaatccta      960

taaatgtgat gtatgtggga aaattttcca tcagagctca gcccttacta gacatcagag     1020

aatccatact agagagaagc cctacaaatg taaagaatgt gaaaagtctt tcagtcagag     1080

ctcaagtctt agtcgacata aaagaataca cactagagaa aaaccttaca aatgtgaagc     1140

atctgataaa tcctgtgaag cgtctgataa atcctgtagt ccaagctcag gcataattca     1200

gcataagaaa attcacacca gagccaaatc ttacaaatgt agcagttgtg aaagagtctt     1260

cagtcgtagt gtccacctta ctcaacatca gaaaattcac aaagagatgc cctgtaagtg     1320

tactgtatgt ggcagtgact tctgccatac ttcataccta cttgaacatc agagggtcca     1380

tcatgaagag aaagcctatg agtatgatga atatgggttg gcctatatta aacaacaagg     1440

aattcatttc agagaaaagc cctatacgtg tagtgaatgt ggaaaagact tcagattgaa     1500

ttcacatctt attcagcatc aaagaattca cacaggagag aaagcacatg aatgtaatga     1560

atgtggaaaa gctttcagtc aaacctcatg ccttattcag catcacaaaa tgcataggaa     1620

agagaaatcg tatgaatgta atgagtatga gggcagtttc agtcatagct cagatcttat     1680

cctgcaacaa gaagtcctca ccagacagaa agcctttgat tgtgatgtat gggaaaagaa     1740

ctccagtcag agagcacatc tagttcaaca tcagagcatt cataccaaag agaactcatg     1800

aatgtaatga agatgggaag atatttatca aattcaggct tcattcagca tctgagagtt     1860

cacaccaggg agaaatcatg tatgtactgc atgtggtaaa gccttcagtc atagctcagc     1920

cattgctcag catcagataa ttcacaccag agagaaaccc tctgaatgtg acgaatgaag     1980

aaaaggtatt agtgttaaac tcttaatcga ctcctgcaaa tctataccag tgagaaatct     2040

tacaaatgta ttgaatgtgg caaatttttc atgctattag tattttcata ccttagtcac     2100

atttggagaa ttcacatggg aataaaattc cattgctgca atgaatgtga aaaagccatc     2160

agtcaaagaa actaccttgt ttagtatcaa attcacgcca tgcaaaaaga ttataaatgt     2220

aataagcatg tatgtgtgtg aggagattca gtcataaccc aacgctcatt caacatcaaa     2280

gaatttatac ctaagagaac ttatttgggt gtagtaaatg gcagatcttt caataggagt     2340

ttaactagtc tttgtcatat cagaatatcc atagtagaca agaatttgat gtaacgcaaa     2400

tggaaaaact cgacaccaca tttcaggctt tacccaacat cgaaataatg gagagaaaat     2460

tgttgattat ttgtttatga aattgttaat acatagtccc aatctttttc attgcacaaa     2520

aatctagggt tgacttggta aatgcagtga cattttctca tggagttcct ttatttaata     2580

tgtattctaa gtaggtacgt ttatttttac ttttttatta taattttgat attaaaaaga     2640

acagagatgg ggtcttgctt tgttgcccag gctggtcttg aactcctggc ctcaagcgat     2700

cctcccacct gtcctcccaa agtgctgggg ttacaggcgt gtgtcactgt gctgggccta     2760

ttttatttat agaactcatt taagctgttt ttattttaat atgccctata aacattttta     2820

tattttttga aattggttct tagtgttcac aacttccata agatactgct aatgcaccag     2880

tattaaaaca catcgacgta agtagctcat ttagcttttt ctgctgttct tggcccaagt     2940

tctttccaaa accaactctt aggcctgctc tttactaggg atcttatgtc gtattgcttt     3000

acagccacaa cacttggatt cctgttgatt aacttctcca ttctcttaag cacctttaga     3060

agatttagaa gtttcctagt tttaagtgtt tcaccagcaa gtattccata cctacttgat     3120

gttgctggtc tggtgtctta tttcctaaag tgaagcatct ttttttaaaa aagaatttga     3180

ttgacaatat atccagtcca atataagtat gaaggattct ctctcctgag attgtagcag     3240

gcagccaaac attttcaaat gatgcccaag gttttagctg tcttgtgtgc atccacagtc     3300

tgcgaagaag acatgataag gacatcaggg agccaacaag actcctaata gcctcactac     3360

attcatccag tgcctattct gcatgcctaa gcttagagtt cttttatata cctctacggc     3420

cagcaaaatg ctcaggtctg ctcttggtag ggtaaacata aagaagatac acaggccggg     3480

catggtggct cacacctgta atcccagcac tttgggaggc tgaggcggat ggatcacgag     3540

gtcaggcagt cgagaccatc ctggccaaca tggtgaaacc ccgtctctac taaaaataca     3600

aaagttagcc gggtgtggtg gcacgcgcct gtaatcccag ctactcagga ggctgaggca     3660

ggagaactgc ttgaacctgg gaggcggagg ttgcagtgag ccgagattgc accactgcac     3720

tccagcctgg gcgacagagc aggactctct ctcaaaaaaa cacaaaaaaa caaaaacaaa     3780

aaaccataca cacacacaca cacacacaaa tcagcatcat aagggaatgt agccttccaa     3840

cagagatgat gctgttcgta tgttaatctc agagacagta tttcaagaga gtggcaggtc     3900

tgttcctggt aaaattttaa ccattaggat tgcagataaa tgtttgaatt ctgctcctct     3960

ctcatcaatc caggacagta tttgaagtgt gagggctttg tgtatagttg tttatccatt     4020

accacatttt tgtattttaa tagtctacag gctatataaa agaacatggc tttttgactg     4080

ataaaagtga ttacagatgt tggctcaagt tcagggccac catcatatac ctaacaagag     4140

ttcatgattc tttaggtaat gtcaaaacat tttgtatttt tccatcttaa gctttataac     4200

attttgtgag taagacaaat gttatttaaa attcttgttg tcagtccagc aattgaggct     4260

ttcatagttc agtgttataa tattcagtag ggaccctcaa caaatatata aaaatatgtt     4320

gctcactcta taatcctcct atggctaacc tctaggatag ttctgccact atattttact     4380

tctttgccat cagcaagagt aggatttcat caaggcaagg taggaatcta aatgaaattg     4440

atatataaat gaattgatct aaatgtaaaa gcaaatgaaa aatgcatgtg ttttttcctg     4500

tcaaacatgt atacccttat gtatagagac cagtagtcac gtatggtgac tgaaacagga     4560

ttatgtaatc cctaaaaagc agaatatgta aaaatcacat gtatgcgttt ggtttaggaa     4620

tgtgcttttg tacttccact tgaataaagg tgtgtttggt attctg                    4666


<210> 2987
<211> 628
<212> DNA
<213> Homo sapiens

<400> 2987
gttctgattt ttgcttgcct ggtgcctggt ttcccagcag tcatgtcatc caggggccct       60

tgcacactgg agacactcat caatcccagc cctagtgtag ctgatgtaaa gatatatcca      120

gaagaaatca ctccactcct accagccata tcaggggaga agattgctga ggaccaaacc      180

tgcttttttc ttcaaatact gttgaagtat atggttattc aggctgcgag cttggagtgg      240

aagaataagg agaatcaaga tactggtttt aaatttcttt ttacattgtt tcgaaagtat      300

tatcttcctc atttatttcc atcatttact aagttaacaa acatctacaa acctgtactt      360

gacatccccc atttgagacc aaagcctgtg tacattacta ccactcgaga caatgagaac      420

atttacagta caaagattcc atatatggca gctcgtgttg tttttattaa gtggattgta      480

accttctttt tggaaaaaaa gtatctaact gcaacacaaa acactaaaaa tggagttgat      540

gtattgccta aaatcatcca ggtatgccat ccatcatctt tttatctgtt aatgcttgtg      600

taataaaata cactggaaca tagccaaa                                         628


<210> 2988
<211> 536
<212> DNA
<213> Homo sapiens

<400> 2988
aacattaaac ctggggaagg cctgggcatg tacatcaaat caacctatga tgggttacac       60

gtgattactg gaaccacaga aaatgtggga tggcagctga aaaatctggt gaagaaattg      120

agagagaatc ccaccggagt tgtgttactg cttaagaagc gccccaccgg gtctttcaac      180

tttactcctg ctcccctgaa aaacctacgg tggaagccac ctcttgtaca gacctcacct      240

ccacccgcga caacccagtc ccctgaaagc actatggata cctcactgaa gaaggagaag      300

tcagccatcc tggatcttta tattcctcct ccgcctgctg ttccctactc tccccgggat      360

gagaatggca gttttgttta tggagggtcc agtaagtgca aacaaccatt gcctggtcct      420

aagggttcag agtccccgaa ttccttcttg gaccaggaaa gccggagacg aagattcacc      480

attgcagact cggatcagtt gcctgggtac tcggtggaaa ccaacattct gcccac          536


<210> 2989
<211> 3185
<212> DNA
<213> Homo sapiens

<400> 2989
gcttcagtag cgagaggggc tgagaaagtg gtgacaccgc cggggtgcgg agggagtccc       60

tgaaacttct cccaacagcc ccagggccaa tcttccctca gcccactccc ctcttcgcca      120

gctcccaggt ccccactcct gtaccggggg tggggtgggg agccaggccc gtctcccgct      180

gggacacaca caggggccgg gagcggggac gggacccccg aggcgggggg gacgaaccga      240

cagacagacg gctgggcgcc cgccccagcg ggcaggcagg caggaggagg cggaggcggg      300

ggtacgacgg ggagcactgg gtctggggag tttcctctca actatcgggg gagaaactcc      360

ccgcagccgg aggaaagacc cagacagtgt tttcctcccg ggggccgtgc tcccccgccc      420

cgcgtagcgg cggtcgccgc caccggcgcc tccacctcta ccatctcctc tttctccacc      480

acctcgggcc ccggtgtccc cggccagcac tatgcccatc ttactgttcc tgatagacac      540

gtctgcctct atgaaccagc gcagccatct gggcaccacc tacctggaca cggccaaagg      600

cgcggtagag accttcatga agctccgtgc ccgggaccct gccagcagag gagacaggta      660

tatgctggtc actttcgaag agccgcccta tgctatcaag gctggatgga aagaaaacca      720

tgcaacgttt atgaatgaat tgaaaaacct tcaggctgaa ggacttacga ctcttggcca      780

atccctaagg acagcttttg atttattaaa tttaaataga ttagtaactg gcatagacaa      840

ctatgggcag ggaagaaacc cttttttctt ggagccagca ataattatca caattactga      900

tgggagcaag ttgactacca ccagtggagt ccaggatgag cttcatttac ctcttaattc      960

tcctttgcct ggaagtgaat tgaccaagga accttttcgt tgggatcaga gactctttgc     1020

attagtgttg cggttgcctg gcaccatgtc agtagaatca gaacagttga caggtgtgcc     1080

tttagatgac tctgcaatca caccaatgtg tgaagtgaca ggcggccgtt catattctgt     1140

gtgttctcca agaatgctta atcagtgtct ggagtccttg gtgcagaaag tacaaagtgg     1200

ggtggtaata aactttgaaa aagcaggacc agatccttcc cctgtagaag atgggcagcc     1260

agatatatca aggccttttg gatctcagcc ttggcatagc tgtcacaaac tcatatatgt     1320

cagaccaaat cctaaaactg gggttcctat aggtcattgg cctgttccag agtctttttg     1380

gccagatcaa aattcgccaa cactaccacc tcgtacatct catcctgtag tgaagttttc     1440

ctgtacagac tgtgaaccaa tggttattga taaacttcct tttgacaaat atgagttgga     1500

accttcacca ctgactcaat ttatcctgga aaggaaatct cctcaaacat gttggcaggt     1560

gtacgtgagc aatagtgcaa aatacagtga acttggtcat ccttttggtt acttgaaagc     1620

cagtacagca ctgaactgtg tcaacttatt tgtgatgcct tacaattatc cagtccttct     1680

tcccctctta gcccttgaag aaagctgtta ggatgatggg agcacctaac ctaatagcag     1740

acagtatgga atatggactt agttacagtg tcatttcata cctcaaaaaa ctgagtcaac     1800

aggccaaaat agaatctgat cgagtcattg gatctgtagg caaaaaagta gtacaggaga     1860

ctggaataaa agtccggagc cgatcacatg gtttatcaat ggcatatagg aaagattttc     1920

aacaactcct ccagggaatt tcagaggatg tccctcacag actgctagac cttaatatga     1980

aggaatacac tgggttccaa gttgctttgc tgaataagga tttgaagcca cagacattta     2040

gaaatgctta tgacatacca agacgaaatc ttttggatca cttaacaaga atgagatcta     2100

atcttttgaa gagcactcgc agatttctga aaggacagga cgaagatcaa gtgcacagtg     2160

ttcctatagc acaaatgggg aactaccagg aatacctcaa gcaagtacct tctccactaa     2220

gagaacttga tcctgatcag ccacgaaggt tgcatacatt tggcaacccc tttaagctgg     2280

ataagaaggg tatgatgata gatgaagcag atgaatttgt ggctggacct caaaataaac     2340

ataaacgacc cggagaacca aatatgcaag ggatccctaa aagacgtcgg tgtatgtctc     2400

cactactaag aggcagacag cagaatcctg ttgtaaacaa tcatattggg ggaaaaggac     2460

cacctgcacc tacaactcaa gcacagccag atcttattaa acctcttcct cttcataaaa     2520

tttcagaaac cactaatgat tcgataatac atgatgtggt tgaaaatcat gttgcagacc     2580

aactttcatc agacattaca ccaaatgcta tggatacgga attttcagca tcttctccag     2640

ccagtttact ggaacggcca accaatcata tggaggctct tggtcatgac catttaggaa     2700

ccaatgacct cactgttggt ggatttttag aaaatcatga ggagccaaga gataaagaac     2760

aatgtgctga agagaacata ccagcatctt cactcaacaa aggaaagaaa ttgatgcatt     2820

gcagaagcca tgaagaggtc aatactgaac taaaagcaca aataatgaaa gagatccgaa     2880

agccaggaag aaaatatgaa agaatcttca ctttactgaa gcatgtgcaa ggcagtttac     2940

aaacaagact aatattttta caaaatgtca ttaaagaagc atcaaggttt aaaaaacgaa     3000

tgctaataga acaactggag aacttcttgg atgaaattca tcgaagagcc aatcagatca     3060

accatattaa tagcaattaa aagaaaatag aatgtggcca cttatttcac tatcttcttc     3120

aaatacaaag taaatacaag actgttgtga tcttgcattc attttctgac atgcattgtt     3180

ggcta                                                                 3185


<210> 2990
<211> 1509
<212> DNA
<213> Homo sapiens

<400> 2990
ctggactgtg ggccacggct gcctgtagaa gtggggccat ctctgtcctc ccccagctcg       60

ggctgcgggg aggggagcat cagcgtgggg gagaacgtgt cagacgtggc tcccacccaa      120

ccatggtggc ccaacacccc gggagacagt gtctctgaag aactaggccc tgggaggagc      180

ggggacactg aggacctctc tccaaattgg cctctcaact cacaggaaga cacagctgcc      240

cagagcagcc caggccgtgg tgaggaggcg gaggcatcgg cggcggaggc tcagggtggg      300

gagcaggcct acctggcagg cctggcaggg cagtaccact tggagcggta cccggacagt      360

tacgagtcca tgtccgagcc gcccattgct catcttttgc gccccgtgct tccccgggcc      420

ttcgccttcc ccgtggaccc ccaggtccag tctgccgctg atgagactgc tgtgcagctg      480

agcgagttgc tgacgctgcc cgtgctcatg aagcgctcca tcacggcacc gctggccgcc      540

cacatctcct tggtgaacaa ggccgctgtc gactacttct tcgtggagct gcacctggag      600

gcgcactatg aggcactgcg gcacttcctg ctgatggagg acggcgagtt cgcccagtcc      660

ctcagcgacc tgctctttga gaagcttgga gctgggcaaa cgcccggaga gctgctcaac      720

ccgctggtgc tgaactctgt gctgagcaag gccctgcagt gcagcctgca tggggacacc      780

ccgcacgcct ccaacctctc cctcgctctc aagtacctgc ccgaggtgtt tgcccccaac      840

gccccggatg tgctgagctg cctggagctc aggtacaagg tggactggcc tctcaacatt      900

gtcatcaccg agggctgcgt gagcaagtac agcggcgtct tctccttcct gctgcagctg      960

aagctcatga tgtgggcgct caaggacgtc tgcttccacc tcaagcgcac agttccgtca     1020

gctgcagctg ttcaagcacg agatgcagca tttcgtgaag gtcatccagg gctacatcgc     1080

caaccagatc ctgcacgtca cctggtgcga gttcagggcc aggttggcca ccgtgggcga     1140

cctggaggag atccagcgtg cgcacgcaga gtacctgcac aaggccgtct tcaggcggcg     1200

cccgtcatga acgtcatcca cagcatcttc agcctcgtgc tcaagttccg cagccagctc     1260

atctcccagg cctgggggcc ccctgggggc ccgcggggtg cagagcaccc caactttgca     1320

ctcatgcagc agtcctacaa caccttcaag tactactccc actttctctt caaagtggtg     1380

accaagctgg tgaaccgcgg ctaccagccc cacctggagg actttctgct gcgcatcaac     1440

ttcaacaact actaccagga cgcctgaggc tgctctgcgg gggacgtgca caataaaggt     1500

gttctcgga                                                             1509


<210> 2991
<211> 4403
<212> DNA
<213> Homo sapiens

<400> 2991
gggcccgtcc tcgaggcgcg cggcgcgggg cgcgggcgcc ggggcctgag gcggcgggcg       60

acgcccgggg gcctgacggc cggccccgcg ccatggtgtg agcgccgccg cccgtgcacg      120

ctccgtccgc cctccgcgcg gcccggccgg cagagagccc cgagcggccc gagagcgcag      180

ccgagcccgc cgccgccgcc cgcggccccg cgaggagagt accgggccgg ctcggctgcc      240

gcgcgaggag cgcggtcggc ggcctggtct gcggctgaga tacacagagc gacagagaca      300

tttattgtta tttgtttttt ggtggcaaaa agggaaaatg gcgaacgact cccctgcaaa      360

aagtctggtg gacatcgacc tctcctccct gcgggatcct gctgggattt ttgagctggt      420

ggaagtggtt ggaaatggca cctatggaca agtctataag ggtcgacatg ttaaaacggg      480

tcagttggca gccatcaaag ttatggatgt cactgaggat gaagaggaag aaatcaaact      540

ggagataaat atgctaaaga aatactctca tcacagaaac attgcaacat attatggtgc      600

tttcatcaaa aagagccctc caggacatga tgaccaactc tggcttgtta tggagttctg      660

tggggctggg tccattacag accttgtgaa gaacaccaaa gggaacacac tcaaagaaga      720

ctggatcgct tacatctcca gagaaatcct gaggggactg gcacatcttc acattcatca      780

tgtgattcac cgggatatca agggccagaa tgtgttgctg actgagaatg cagaggtgaa      840

acttgttgac tttggtgtga gtgctcagct ggacaggact gtggggcgga gaaatacgtt      900

cataggcact ccctactgga tggctcctga ggtcatcgcc tgtgatgaga acccagatgc      960

cacctatgat tacagaagtg atctttggtc ttgtggcatt acagccattg agatggcaga     1020

aggtgctccc cctctctgtg acatgcatcc aatgagagca ctgtttctca ttcccagaaa     1080

ccctcctccc cggctgaagt caaaaaaatg gtcgaagaag ttttttagtt ttatagaagg     1140

gtgcctggtg aagaattaca tgcagcggcc ctctacagag cagcttttga aacatccttt     1200

tataagggat cagccaaatg aaaggcaagt tagaatccag cttaaggatc atatagatcg     1260

taccaggaag aagagaggcg agaaagatga aactgagtat gagtacagtg ggagtgagga     1320

agaagaggag gaagtgcctg aacaggaagg agagccaagt tccattgtga acgtgcctgg     1380

tgagtctact cttcgccgag atttcctgag actgcagcag gagaacaagg aacgttccga     1440

ggctcttcgg agacaacagt tactacagga gcaacagctc cgggagcagg aagaatataa     1500

aaggcaactg ctggcagaga gacagaagcg gattgagcag cagaaagaac agaggcgacg     1560

gctagaagag caacaaagga gagagcggga agctagaagg cagcaggaac gtgaacagcg     1620

aaggagagaa caagaagaaa agaggcgtct agaggagttg gagagaaggc gcaaagaaga     1680

agaggagagg agacgggcag aagaagaaaa gaggagagtt gaaagagaac aggagtatat     1740

caggcgacag ctagaagagg agcagcggca cttggaagtc cttcagcagc agctgctcca     1800

ggagcaggcc atgttactgc atgaccatag gaggccgcac ccgcagcact cgcagcagcc     1860

gccaccaccg cagcaggaaa ggagcaagcc aagcttccat gctcccgagc ccaaagccca     1920

ctacgagcct gctgaccgag cgcgagaggt ggaagataga tttaggaaaa ctaaccacag     1980

ctcccctgaa gcccagtcta agcagacagg cagagtattg gagccaccag tgccttcccg     2040

atcagagtct ttttccaatg gcaactccga gtctgtgcat cccgccctgc agagaccagc     2100

ggagccacag gttcctgtga gaacaacatc tcgctcccct gttctgtccc gtcgagattc     2160

cccactgcag ggcagtgggc agcagaatag ccaggcagga cagagaaact ccaccagtat     2220

tgagcccagg cttctgtggg agagagtgga gaagctggtg cccagacctg gcagtggcag     2280

ctcctcaggg tccagcaact caggatccca gcccgggtct caccctgggt ctcagagtgg     2340

ctccggggaa cgcttcagag tgagatcatc atccaagtct gaaggctctc catctcagcg     2400

cctggaaaat gcagtgaaaa aacctgaaga taaaaaggaa gttttcagac ccctcaagcc     2460

tgctgatctg accgcactgg ccaaagagct tcgagcagtg gaagatgtac ggccacctca     2520

caaagtaacg gactactcct catccagtga ggagtcgggg acgacggatg aggaggacga     2580

cgatgtggag caggaagggg ctgacgagtc cacctcagga ccagaggaca ccagagcagc     2640

gtcatctctg aatttgagca atggtgaaac ggaatctgtg aaaaccatga ttgtccatga     2700

tgatgtagaa agtgagccgg ccatgacccc atccaaggag ggcactctaa tcgtccgcca     2760

gagtacagtt gaccaaaagc gtgccagcca tcatgagagc aatggctttg ccggtcgcat     2820

tcacctcttg ccagatctct tacagcaaag ccattcctcc tccacttcct ccacctcctc     2880

ctccccatcc tccagccagc cgacacccac catgtcccca cagacacccc aggacaagct     2940

cactgctaat gagactcagt ccgctagtag cacactccag aaacacaaat cttcctcctc     3000

ctttacacct tttatagacc ccagattact acagatttct ccatctagcg gaacaacagt     3060

gacatctgtg gtgggatttt cctgtgatgg gatgagacca gaagccataa ggcaagatcc     3120

tacccggaaa ggctcagtgg tcaatgtgaa tcctaccaac actaggccac agagtgacac     3180

cccggagatt cgtaaataca agaagaggtt taactctgag attctgtgtg ctgccttatg     3240

gggagtgaat ttgctagtgg gtacagagag tggcctgatg ctgctggaca gaagtggcca     3300

agggaaggtc tatcctctta tcaaccgaag acgatttcaa caaatggacg tacttgaggg     3360

cttgaatgtc ttggtgacaa tatctggcaa aaaggataag ttacgtgtct actatttgtc     3420

ctggttaaga aataaaatac ttcacaatga tccagaagtt gagaagaagc agggatggac     3480

aaccgtaggg gatttggaag gatgtgtaca ttataaagtt gtaaaatatg aaagaatcaa     3540

atttctggtg attgctttga agagttctgt ggaagtctat gcgtgggcac caaagccata     3600

tcacaaattt atggccttta agtcatttgg agaattggta cataagccat tactggtgga     3660

tctcactgtt gaggaaggcc agaggttgaa agtgatctat ggatcctgtg ctggattcca     3720

tgctgttgat gtggattcag gatcagtcta tgacatttat ctaccaacac atatccagtg     3780

tagcatcaaa ccccatgcaa tcatcatcct ccccaataca gatggaatgg agcttctggt     3840

gtgctatgaa gatgaggggg tttatgtaaa cacatatgga aggatcacca aggatgtagt     3900

tctacagtgg ggagagatgc ctacatcagt agcatatatt cgatccaatc agacaatggg     3960

ctggggagag aaggccatag agatccgatc tgtggaaact ggtcacttgg atggtgtgtt     4020

catgcacaaa agggctcaaa gactaaaatt cttgtgtgaa cgcaatgaca aggtgttctt     4080

tgcctctgtt cggtctggtg gcagcagtca ggtttatttc atgaccttag gcaggacttc     4140

tcttctgagc tggtagaagc agtgtgatcc agggattact ggcctccaga gtcttcaaga     4200

tcctgagaac ttggaattcc ttgtaactgg agctcggagc tgcaccgagg gcaaccagga     4260

cagctgtgtg tgcagacctc atgtgttggg ttctctcccc tccttcctgt tcctcttata     4320

taccagttta tccccattct tttttttttt cttactccaa aataaatcaa ggctgcaatg     4380

cagctggtgc tgttcagatt cta                                             4403


<210> 2992
<211> 456
<212> DNA
<213> Homo sapiens

<400> 2992
gcccttcaga tctctgagaa cttgtttagc aacaaagtcc tcaatgcctt gaaaccagaa       60

aaagatgtgg atggagtaac agacataaac ctggggaagc tggtgcgagg ggatgcccat      120

gaatgttttg tttcacctgt tgccaaagct gtaattgaac ttcttgaaaa atcagtaggt      180

gtcaacctag atggaaagaa gattttggta gtgggggccc atgggtcttt ggaagctgct      240

ctacaatgcc tgttccagag aaaagggtcc atgacaatga gcatccagtg gaaaacacgc      300

cagcttcaaa gcaagacgga gtctcgttct gtcaccaggc tggagtgcag gcgcgtgatc      360

taggctcact gcaagctctg cctcccaggt tgaagtgatt ctcctgtgaa agggaattat      420

ttttgatgag tcattaaagt atatccattc ccagaa                                456


<210> 2993
<211> 2088
<212> DNA
<213> Homo sapiens

<400> 2993
ggggagtggg agccgcgggg ttcagagcga tgattccccc acaggaggca tccgctcgac       60

ggcgggagat tgaggacaag ctgaagcagg aggaggagac tctgtccttc atccgagaca      120

gcctggagaa gagcgaccag ctcactaaga acatggtgtc tatcttatca tcctttgaga      180

gccgccttat gaagctggag aactccatca tccctgtgca caagcagacg gagaatctgc      240

agcggctgca ggagaatgtt gagaagacgc tgtcctgcct ggaccatgtc atcagctact      300

accatgtggc cagtgacact gagaagatca tcagagaggg ccccacaggt aggctggaag      360

agtacctggg aagcatggcc aagattcaga aggcagtgga gtatttccag gacaacagcc      420

cagacagccc ggaactcaac aaagtgaaac tgctctttga gcgcgggaag gaggccctgg      480

agtccgaatt tcgcagcctg atgacgcggc acagtaaggt cgtctcgccc gtgctcatct      540

tggatctgat cagtggtgac gatgatctgg aggcccagga ggacgtgacc ctggagcacc      600

tgcccgagag cgtgctccag gatgtcattc gcatctcccg ctggctggtg gaatatggcc      660

gcaaccaaga tttcatgaac gtctactacc agatacgctc cagccagctg gaccgctcca      720

tcaaaggact gaaggagcat ttccataaga gcagttcttc ctctggggtt ccctactccc      780

ctgctatccc caacaagagg aaagacacac ctaccaagaa gccagtcaag cggccaggga      840

cgatccgtaa ggctcagaac cttctgaaac agtattccca gcatggtcta gatgggaaaa      900

aggggggctc taacctcatt cctctggaag ggagagatga catgctggac gtggagaccg      960

atgcctacat ccactgcgtc agtgccttcg tcaagctggc gcagagcgag taccagctgc     1020

tggccgacat catccccgag caccaccaga agaagacctt cgactccctg atacaggatg     1080

ccctggatgg gctgatgctt gaaggggaga acatcgtgtc tgctgcccgg aaggccattg     1140

tgcgacacga cttctccacg gtgctcaccg tcttccccat cctgcgacac ctcaagcaga     1200

ccaagcctga gtttgaccag gtgctccagg gcacggctgc cagcacaaag aacaagctgc     1260

ctggcctcat cacatccatg gagaccatcg gtgccaaagc gctggaggac ttcgcagaca     1320

acatcaagaa tgacccggac aaggagtaca acatgccgaa ggacggcacc gtacacgagc     1380

tcaccagcaa tgccatcctc ttcctgcagc agcttttgga cttccaggag acggcaggcg     1440

ccatgctggc ctcccaaggt aaagtgctgg gcaacctgca gttgaacttg ctgagcaagt     1500

ccaaggtgta cgaggaccca gctctgagcg ccatcttcct gcacaacaac tacaattaca     1560

tcctcaagtc cctggagaag tctgaactga tccagctggt ggcagtgaca cagaagactg     1620

ctgagcgctc ctaccgggag cacattgagc agcagatcca gacctaccag cgcagctggt     1680

taaaggtgac tgattacatc gcagagaaga atctacctgt gttccagccg ggagtcaagc     1740

tccgggacaa ggagcggcag attatcaagg agcgttttaa gggcttcaat gatggcctcg     1800

aagaactgtg caaaatccag aaggcctggg ctattccaga cacagagcag agggacagga     1860

ttcgccaggc ccagaagacc attgtcaagg agacctacgg ggcctttcta cagaagtttg     1920

gcagcgtgcc cttcaccaag aacccggaga agtacatcaa gtacggggtg gagcaggtgg     1980

gcgacatgat cgatcgcctt ttcgacacct ctgcctgagc ctgctgctag ccctgcctgg     2040

ttccaccaga ctggcgtgtc attggacaga taaaccagtg ttagcttg                  2088


<210> 2994
<211> 2252
<212> DNA
<213> Homo sapiens

<400> 2994
ttcgcggtgc caccgccccg cccacgcctc ctcgccggcc tccgagtgcg tcacgtgacg       60

ggtcggtggc gctggcggtt gctgtcagct gattcccggg gttggtggca gcggcggtag      120

cagcaatgga ctttctcctg gggaacccgt tcagctctcc agtgggacag cgcatcgaga      180

aagccacaga tggctccctg cagagcgagg actgggccct caacatggag atctgcgaca      240

tcatcaacga gacggaggaa ggtcccaaag atgccctccg agcagtaaag aagagaatcg      300

tggggaataa gaacttccac gaggtgatgc tggctctcac agtcttagaa acctgtgtca      360

agaactgcgg gcaccgcttc cacgtgctgg tggccagcca ggacttcgtg gagagtgtgc      420

tggtgaggac catcctgccc aagaacaacc cacccaccat cgtgcatgac aaagtgctca      480

acctcatcca gaccgtgttc aactcagaga cacaatcagg acaggattct gtgggcactg      540

actccagcca gcaagaggac tctggccagc atgctgcccc tctgcccgcc ccgcccatac      600

tctccggtga cacgcccata gcaccaaccc cggaacagat tgggaagctg cgcagtgagc      660

tggagatggt gagtgggaac gtgagggtga tgtcggagat gctgacggag ctggtgccca      720

cccaggccga gcccgcagac ctggagctgc tgcaggagct caaccgcacg tgccgagcca      780

tgcagcagcg ggtcctggag ctcatccctc agatcgccaa tgagcagctg acagaggagc      840

tgctcatcgt caatgacaat ctcaacaatg tgttcctgcg ccatgaacgg tttgaacggt      900

tccgaacagg ccagaccacc aaggccccaa gtgaggccga gccggcagct gacctgatcg      960

acatgggccc tgacccagca gccaccggca acctctcatc ccagctggca ggaatgaacc     1020

tgggctccag cagtgtgaga gctggcctgc agtctctgga ggcctctggt cgactggaag     1080

atgagtttga catgtttgcg ctgacacggg gcagctcact ggctgaccaa cggaaagagg     1140

taaaatacga agccccccaa gcaacagacg gcctggctgg agccctggac gcccggcagc     1200

agagcactgg cgcgatccca gtcacccagg cctgcctcat ggaggacatc gagcagtggc     1260

tgtccactga cgtgggtaat gatgcggaag agcctaaggg ggtcaccagc gaagaatttg     1320

acaaattcct ggaagaacgg gccaaagccg cggaccgatt gcccaacctc tccagcccct     1380

cagctgaggg gcccccgggt cccccatctg gcccagcgcc ccggaagaag acccaggaga     1440

aagatgatga catgctgttt gccttatgag tgtggggtct ggcaccctgc agcccaggtc     1500

cccactgctc tcacaccctt aggctgggac ctccctccct cctctggtgt taaggctgct     1560

ttgggggtgg cttgttaccc ccttttcctc ctctttgaag acggagctgc cccagctgtg     1620

gctgggggtg tggaggcagt gggatgaact gggggacagg tctgcgctgc agtgggatct     1680

ggctgctctg cctcctttcc caccccagct gaccatgaga ctttgctgag aagtggaggc     1740

cccaggacag gctggctggc tggctggctg cttgacccag tgtgactctc cttcactgag     1800

tgataccctg ctccgggccc atgccccaag gagcccttca gagcccacac tgccagtcga     1860

ggcctggctg gaggctggcc acagtggaaa ttctgccgag cctcttgtcc cttccctgct     1920

ctgctgcatg gggccccatg gctttggctg gccactgagg gtagggtgtg gaggtgtgga     1980

ggccccctga ggagctgcgg cggcccaggt acgaagctgc aactctgcgc gcagtgggcg     2040

agatctcatc agccccaggc tgcaggtgag gcttcagggg atgctggggc cccactgccc     2100

ctccgctgcc ttgccctcca tccttcctct gttccttctg gccgggcacc acagcactgg     2160

ggctcacctc ttggttgatc ctcttgtact gggagaggtg ccttttgtat ccccaattaa     2220

aggtagaaaa ccaccctgct agcagcattg tc                                   2252


<210> 2995
<211> 2248
<212> DNA
<213> Homo sapiens

<400> 2995
gtctttccct ttgacaagtc gctgctgctg cagcaaaaat aaaggacgcg accgccgcag       60

cctctgcgga gccgggctcg ggtcgccgga gccgcgcccc accccgccag ctccagagcc      120

acgactaatg gctgaaggat aaatcaacat ggcaactatg attccaccag tgaagctgaa      180

atggcttgaa cacttgaaca gctcctggat tacagaggac agtgaatcta ttgctacaag      240

agagggagtt gctgttctgt attctaaact ggttagcaat aaggaagtag tacctttgcc      300

ccaacaagtt ttatgcctca aaggaccaca gttgccagac tttgaacgtg agtctctttc      360

aagtgatgag caggaccact atttggatgc ccttcttagc agccagctag cattggcaaa      420

gatggtatgt tcagattccc catttgccgg ggcacttaga aaacgactgc ttgtactcca      480

gcgtgtcttt tatgcacttt ctaataaata ccatgacaaa ggcaaggtga agcagcagca      540

gcattctccg gagagcagtt ctggttcagc agatgtccat tctgttagtg aacgcccccg      600

gtcaagcact gatgcactta tagaaatggg tgttcgaact ggtctaagtt tattatttgc      660

gcttctaaga caaagttgga tgatgcctgt gtcaggacct ggtctcagtc tttgcaacga      720

tgtcattcat actgcaattg aagttgtgag ctctttgcca ccattatcat tagcaaatga      780

aagcaagatt cctcctatgg gcttggactg cttatcgcaa gtaacaacat ttcttaaagg      840

agtcactatt cctaattctg gggcagacac tttaggtcgt agattagctt ctgagttgct      900

gcttggtttg gcagctcaac gaggctcatt gcgatatctt cttgaatgga tagaaatggc      960

tttgggggct tcggcagttg tacacaccat ggagaaaggc aaactactct caagccagga     1020

aggaatgatc agctttgact gctttatgac catattaatg cagatgaggc gttctttgat     1080

atcagaaaac caggactctg cagatgttga tcctcaggag cattcattta ctcgaactat     1140

tgatgaagaa gctgaaatgg aagaacaggc tgagagagac cgggaagagg ggcatccgga     1200

gccagaggat gaagaggagg aacgggaaca tgaagtgatg acagctggca aaatctttca     1260

gtgtttcctc tcagcccgtg aagtagctcg tagccgagac cgagatagaa tgaacagtgg     1320

ggcagggtct ggggctcgag ctgatgatcc acctcctcag tctcagcaag agcgaagggt     1380

cagcacagac cttcctgagg gtcaggatgt gtacactgct gcatgcaact ccgtgatcca     1440

tcggtgtgcc ctgttaatat taggagtaag tcctgtgata gatgagcttc agaagcgaag     1500

agaagaagga cagttgcagc aaccttcaac aagtgcctct gaagggggtg gacttatgac     1560

caggagtgaa agtcttactg cagagagccg gctagtccac acaagcccaa attatagact     1620

gatcaaatcg aggagtgaat ctgatttgtc tcagcctgaa tcagatgaag agggttacgc     1680

actgagtggc agacgaaatg ttgatttgga tttggcagca tctcacagaa agagaggtcc     1740

tatgcacagt caattggaat ccctgagtga ctcttgggct cgcctgaaac atagcagaga     1800

ctggttatgc aactcctcct attcctttga gtcagatttt gatcttacca agtctttggg     1860

agttcacact ttgattgaaa atgttgtaag ctttgtgagt ggagatgtgg ggaatgcccc     1920

aggttttaaa gagccagagg aaagtatgtc tacaagtccc caggcctcca tcattgcaat     1980

ggaacagcag cagttaaggg cagaacttcg tttagaggca cttcatcaga tcctcgttct     2040

attgtctggg atggaagaaa aaggtagcat ctcactggca ggaagcagat tgagttcagg     2100

cttccagtcc tccacactac tcacgtctgt gaggctgcag ttcctagcag ggtgttttgg     2160

tttaggcact gttggacaca caggaggcaa gggagagagt ggccgattgc atcactatca     2220

ggatgggatc agagcagccc gaggttat                                        2248


<210> 2996
<211> 1034
<212> DNA
<213> Homo sapiens

<400> 2996
acaattgcat tcccgggctg gatgccggtt gttaagcgcg ctgttgcttt gtaaaaatgc       60

gtgtgttctg gtgttttggc tggggcaggg aggggacacc ccacgaggtc tggggctgtt      120

gcccttgtgt catccccccg ccttttaact gcaaaggtca ccatggctga ccgggctgct      180

gccgaaaggg cctgcaagga tcccaatccc atcattgatg gcagaaaggc caacgtgaac      240

ctggcatact taggagcaaa accaaggatc atgcaaccag gttttgcctt tggtgttcaa      300

caacttcatc cagcccttat acaaagacct ttcgggatac ctgcccacta tgtctatccg      360

caggcttttg tgcagccggg agtggtcatt ccacacgtcc agccgacagc agctgccgcc      420

tccaccaccc cttacattga ttacactgga gctgcatacg cacaatactc agcagctgct      480

gctgctgccg ccgccgctgc tgcctatgac cagtacccct atgcagcctc tccagctgct      540

gcaggatatg ttactgctgg gggctatggc tacgcagtcc agcagccaat caccgcagcg      600

gcacctggga cagctgccgc cgccgctgca gcagctgctg ccgctgcagc atttggccag      660

taccagcctc agcagctgca gacagaccga atgcaataga ccagccatct gatcaaagtt      720

gaattgtttt ctctttccct cccaattttc caatttttag tagctaataa gagagttaac      780

attgacttaa cagctttaaa aaaaaaaaca gccatgctat tgtgaagcag agttattatt      840

ttttttatac tccaggtagt gttctagatg agaaagaggt aagaatgagg ggaatgggca      900

caattttgga aatcaatccc aaagagcctg agtaaatgaa aggccactac gaaatgacgc      960

caggagtaac aacggaactt cacttttgta acgggatttt tatttttgct ctttttatag     1020

tatcagggaa gcaa                                                       1034


<210> 2997
<211> 2014
<212> DNA
<213> Homo sapiens

<400> 2997
agagcgtcat gggacatgta gttccggcat cgcgcctggt ggcggagttc tgccgagtgg       60

ggcgccgcgg ccgctattgt cccgccccct gctccgcaag attcgagcct gagcggcctg      120

ggcgtctcga gaggtgagag agttggcggc gaggtctcgg cggctaagcg agcgtcggcg      180

actgtctctc cgcgagagga ggcaagttgg ggtccaggct ccaaagccgg tggccgcgta      240

ccgcggtgga gccgctgtct ttgaggtctg aggagagaac agacagagtc tagctctttc      300

acccaggctg gagtgaagtg gtgcaatctc agctcagtgc aacctccgcc ccctgggttc      360

aagtgattct cctgcctcag cctccccagt agctgggatt acagtgatat cctgagagaa      420

gatgggaaag ggctgcaagg ttgtggtttg tggattgtta tctgtgggga aaactgcaat      480

tttggagcag ctcctttatg gaaatcatac tattggaatg gaagattgcg aaacaatgga      540

agatgtatac atggcttcag tagaaacaga ccgaggagta aaagaacagt tacatcttta      600

tgacaccaga ggtctacagg aaggcgtgga gctgccaaag cattattttt catttgctga      660

tggcttcgtt cttgtgtaca gtgtgaataa ccttgaatcc tttcaaagag tggagcttct      720

gaagaaagaa atcgataagt tcaaagacaa aaaagaggta gcaattgtgg tattaggaaa      780

caaaatcgac ctttctgagc agagacaagt ggacgctgaa gtggcacagc agtgggcaaa      840

aagtgagaaa gtaagactgt gggaggtgac tgttacagat cggaaaactc tgattgaacc      900

attcacttta ttagccagta aactttctca accccagagc aaatcaagct ttcctttgcc      960

tgggaggaaa aacaaaggga actctaattc tgagaactaa aaatcagtaa tttccacaat     1020

tgtatgttga atagtgattg cctttaagtg tctgtgaaca tggagtaata ttactattta     1080

aaataggcca tttgtatcta cctttggtcc ttaggaaaat tcctaaggaa gtcaattaat     1140

gcactttaga tgttaaaagt atttgggcta aggttattat tgcctgatat gaaataatat     1200

attcttattc tcattgtttg aaacctgtct ttgaaattag cacctttgtt atttatgttg     1260

tacttgtgaa aacagtaaaa tagtttggat agttatgcaa atgcacctat gtgtaacttc     1320

cccccaaccc caagctgttt cggaagatat cataatcatt ctgtgtaaca ttatgcaaac     1380

ttctaagccc aaacatgact ttgtttttaa aaagttcatt aatctaatgt ctaggattat     1440

aaaacatttt tttgtgtcta aattggaccc aaaacattga acagtttggg gtagtaagct     1500

aaatttcatc ttgtggagat tttgctaaac agactaagac ccatgattta gctttgctca     1560

aattagaatg tttagcatga gttgaggtac caggtagtgt taagtaggtt catcacgctc     1620

taaggccgtt ttttccttag ccagacccct gttgatagac cagatacttg agggcaaact     1680

gtttgctcct cctcttgaaa atgattaggc acttaaggac agtaaagctg tattttctgg     1740

aaggaagact gtatcttctg gaatagtttt ctagaaaact agtcatatac aataaaagta     1800

tcaaaaatat tgggctctaa tttgatctga cttagatgtc tgagtttgtg ttgtttctct     1860

aaagattttg gcaagactca agcaatgtgg ctgactgtaa ctttattaat ttaaaaggta     1920

ggaagtaagc tacttagtgg tttcacctgt gaaataacta ttttgactga aatgtaaaat     1980

aagctattca acaaagaaca tattaaaaca tcaa                                 2014


<210> 2998
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 2998
atgaacagaa gccaaccagg tctgctgaga acagacccag tccctgagga aggagaagat       60

gttgctgcca cgatcagtgc cacagagacc ctctcggaag aggagcagga agagctaaga      120

agagaacttg caaaggtaga agaagaaatc cagactctgt ctcaagtgtt agcagcaaaa      180

gagaagcatc tagcagagat caagcggaaa cttggaatca attctctaca ggaactaaaa      240

cagaacattg ccaaagggtg gcaagacgtg acagcaacat ctgcttacaa gaagacatct      300

gaaaccttat cccaggctgg acagaaggcc tcagctgctt tttcgtctgt tggctcagtc      360

atcaccaaaa agctggaaga tgtaaaaaac tccccaactt ttaaatcatt tgaagaaaag      420

gtcgaaaact taaagtctaa agtaggggga accaagcctg ctggtggtga ttttggagaa      480

gtcttgaatt cggctgcaaa tgctagtgcc accaccacgg agcctcttcc agaaaagaca      540

caggagagcc tgtgagattc ctacctttgt tctgctaccc actgccagat gctgcaagcg      600

aggtccaagc acatcttgtc aacatgcatt gccatgaatt tctaccagat gtgcttttat      660

ttagctttac atattccttt gaccaaatag tttgtgggtt aaacaaaatg aaaatatctt      720

cacctctatt cttgggaaac accctttagt gtacatttat gttcctttat ttaggaaaca      780

ccattataaa aacacttata gtaaatgggg acattcacta taatgatcta agaagctaca      840

gattgtcata gttgttttcc tgctttacaa aattgctcca gatctggaat gccagtttga      900

cctttgtctt ctataatatt tccttttttt cccctctttg aatctctgta tatttgattc      960

ttaactaaaa ttgttctctt aaatattctg aatcctggta attaaaagtt tgggtgtatt     1020

ttctttacct ccaaggaaag aactactagc tacaaaaaat attttggaat aagcattgtt     1080

ttggtataag gtacatattt tggttgaaga caccagactg aagtaaacag ctgtgcatcc     1140

aatttattat agttttgtaa gtaacaatat gtaatcaaac ttctaggtga cttgagagtg     1200

gaacctccta tatcattatt tagcaccgtt tgtgacagta accatttcag tgtattgttt     1260

attataccac ttatatcaac ttatttttca ccaggttaaa attttaattt ctacaaaata     1320

acattctgaa tcaagcacac tgtatgttca gtaggttgaa ctatgaacac tgtcatcaat     1380

gttcagttca aaagcctgaa agtttagatc tagaagctgg taaaaatgac aatatcaatc     1440

acattagggg aaccattgtt gtcttcactt aatccattta gcactattta aaataagcac     1500

accaagttat atgactaata taacttgaaa attttttata ctgaggggtt ggtgataact     1560

cttgaggatg taatgcatta ataaaaatca actcatcatt ttctacttgt tttcaatgtg     1620

ttggaaactg taaaatgata ctgtagaacc tgtctcctac tttgaaaact gaatgtcagg     1680

gctgagtgaa tcaaagtgtc tagacatatt tgcatagagg ccaaggtatt ctattctaat     1740

aactgcttac tcaacactac caccttttcc ttatactgta tatgattatg gcctacaatg     1800

ttgtatttgt tatttattaa attgtgattg ttttattatt gtttatgcca aatgttaact     1860

gccaagcttg gagtgaccta aagcattttt taaaagcatg gctagattta cttcagtata     1920

aattatctta tgaaaaccaa attttaaaag ccacaggtgt tgattgttat aaaataacat     1980

gctgccattc ttgattgcta gagtttttgt tagtactttg gatgcaatta aaactatgtg     2040

ctatcacatg tgaaaagctt aataaattcc atctatcagt                           2080


<210> 2999
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 2999
gggagattac ggggcgggga cgagctgtcg cgctggttgc tcgtgcagga gcgggacccg       60

gaacagaccg ccgtgagaga ggaggggtgc cggccgggat tcgcggcccg gagctcggga      120

ccggttgctt cattccagcc tcgcagtcac ctctgtgccc tgctggttgt cttcccagcg      180

ctgctgtagt tgccttccat ggatctatag gagagcaagt cctccaggag aagaagtcct      240

caccagtgaa cggagacctc tctgaactaa ggataccatg gccacgtcag ccccactacg      300

gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac      360

cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg      420

gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt      480

gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca      540

gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa      600

gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg      660

ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa      720

aatcctgaac cacctgagta ccctaaggag ggacagagac aaaattcagg gcttccaggc      780

aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat      840

tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga      900

acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg      960

cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca     1020

gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa     1080

gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga     1140

taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt     1200

ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct     1260

gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc     1320

ccagcagttt gactgtgagc ctggggtgct aggcagcaag ggcttcacct ggggcaaggt     1380

ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga     1440

ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga     1500

cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga     1560

ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag     1620

gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc     1680

cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag     1740

agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca     1800

ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct     1860

caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc     1920

caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc     1980

ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct ccccattgct     2040

gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt     2100

ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct     2160

ttcctttttg accacgacct tggccccagc tctgcactct ctggaataag ggcccgatgc     2220

agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc     2280

attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc     2340

ttccctggca ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa     2400

tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag     2460

cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc     2520

atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat     2580

ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga     2640

ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc     2700

aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc     2760

gggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact     2820

ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc     2880

ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa     2940

cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa     3000

ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa     3060

gttttaagtc ctccaccctg ttctaagaga ctgttccaac ggctctgggc ctcagtggtc     3120

acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca     3180

catgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta     3240

tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat     3300

aaagacttgt tgaatgaa                                                   3318


<210> 3000
<211> 804
<212> DNA
<213> Homo sapiens

<400> 3000
gaggcggcta ctggctcaag aggacgacag aagccagtct ctgatgccca ccgcattctc       60

cagcttcagg cctcaagccc tgtagccgag aaggcgaggc ctaatgttac accaccggcc      120

aaggaggcgg gtttggtgcg gccactccaa ggccaaagcg agaaaatctt actgcgcacg      180

cgcaatagac agccgatgga gccaccgatg gagccgtccg gaggggagca agagcccgga      240

gccgtcaggt tcctggacct gccctgggaa gacgtgctgc tcccacacgt cctgaaccgg      300

gtcccgctgc gccagctgct ccggctgcag cgcgttagcc gggccttccg gtcgctggtg      360

cagcttcacc tggccgggct gcgtcgcttc gatgccgcgc aggtgggtcc gcagatcccg      420

cgggccgcat tggcccggct gctgcgggat gccgaggggc tgcaggagct ggcactggcg      480

ccgtgtcacg aatggctgtc agacgaggac ctggtgccgg tgctggcgcg gaatccgcag      540

ctgcggagtg tggcgttggg cggctgcggg caactgagtc gccgggcgct tggggctttg      600

gccgagggct gcccacgcct gcagcgcctg tcgctcgcgc actgtgactg ggtggacggg      660

ctggcgctgc gcggcctcgc tgatcgctgc ccggccctgg aggagctgga tctcaccgcc      720

tgccgccagc tcaaggacga ggccatcgtg tacctggcgc agaggcgcgg cgctggtctc      780

cgcagcctct ctctggccgt caac                                             804


<210> 3001
<211> 2441
<212> DNA
<213> Homo sapiens

<400> 3001
aactttgcct ctcctttacg ccaaatacgt gtccttatat ctgaatctac accactatta       60

tagattcacc ttctttgaga agtccctatt tgaagagagg aaaattcagg ctacttgtaa      120

ccctcttatt ctttttagac ggagttttcc ctcttgttgc ccaggctaga gtgcaatggc      180

gcgatctcgg ctcaccgcaa cctccgcctc ccgggttcaa gcgactctcc tgcctcagcc      240

tcccgagtag ctggaattac aggcatgcgc caccactccc ggctaatttt gtatttttag      300

tagagacggg gtttctccat attggtcagg ctggtctcaa acccccggcc tcagcctcag      360

gtgatccgcc cgcctcggcc tcccaaactg gtggggttac aggtgtgagc cacggaacgc      420

ggctcctctt ccttctggat atggctgtct cagatggcca gaggcctcgg aaaggcttcc      480

ggtttcccgg caggcccgag tggggctgaa cttccggcct caggacgcag gcgcgggccg      540

ctcatttcgc tctttccggc ggtgctcgca agcgaggcag ccatgtctta tcccgctgat      600

gattatgagt ctgaggcggc ttatgacccc tacgcttatc ccagcgacta tgatatgcac      660

acaggagatc caaagcagga ccttgcttat gaacgtcagt atgaacagca aacctatcag      720

gtgatccctg aggtgatcaa aaacttcatc cagtatttcc acaaaactgt ctcagatttg      780

attgaccaga aagtgtatga gctacaggcc agtcgtgtct ccagtgatgt cattgaccag      840

aaggtgtatg agatccagga catctatgag aacagctgga ccaagctgac tgaaagattc      900

ttcaagaata caccttggcc cgaggctgaa gccattgctc cacaggttgg caatgatgct      960

gtcttcctga ttttatacaa agaattatac tacaggcaca tatatgccaa agtcagtggg     1020

ggaccttcct tggagcagag gtttgaatcc tattacaact actgcaatct cttcaactac     1080

attcttaatg ccgatggtcc tgctcccctt gaactaccca accagtggct ctgggatatt     1140

atcgatgagt tcatctacca gtttcagtca ttcagtcagt accgctgtaa gactgccaag     1200

aagtcagagg aggagattga ctttcttcgt tccaatccca aaatctggaa tgttcatagt     1260

gtcctcaatg tccttcattc cctggtagac aaatccaaca tcaaccgaca gttggaggta     1320

tacacaagcg gaggtgaccc tgagagtgtg gctggggagt atgggcggca ctccctctac     1380

aaaatgcttg gttacttcag cctggtcggg cttctccgcc tgcactccct gttaggagat     1440

tactaccagg ccatcaaggt gctggagaac atcgaactga acaagaagag tatgtattcc     1500

cgtgtgccag agtgccaggt caccacatac tattatgttg ggtttgcata tttgatgatg     1560

cgtcgttacc aggatgccat ccgggtcttc gccaacatcc tcctctacat ccagaggacc     1620

aagagcatgt tccagaggac cacgtacaag tatgagatga ttaacaagca gaatgagcag     1680

atgcatgcgc tgctggccat tgccctcacg atgtacccca tgcgtattga tgagagcatt     1740

cacctccagc tgcgggagaa atatggggac aagatgttgc gcatgcagaa aggtgaccca     1800

caagtctatg aagaactttt cagttactcc tgccccaagt tcctgtcgcc tgtagtgccc     1860

aactatgata atgtgcaccc caactaccac aaagagccct tcctgcagca gctgaaggtg     1920

ttttctgatg aagtacagca gcaggcccag ctttcaacca tccgcagctt cctgaagctc     1980

tacaccacca tgcctgtggc caagctggct ggcttcctgg acctcacaga gcaggagttc     2040

cggatccagc ttcttgtctt caaacacaag atgaagaacc tcgtgtggac cagcggtatc     2100

tcagccctgg atggtgaatt tcagtcagcc tcagaggttg acttctacat tgataaggac     2160

atgatccaca tcgcggacac caaggtcgcc aggcgttatg gggatttctt catccgtcag     2220

atccacaaat ttgaggagct taatcgaacc ctgaagaaga tgggacagag accttgatga     2280

tattcacaca cattcaggaa cctgttttga tgtattatag gcaggaagtg tttttgctac     2340

cgtgaaacct ttacctagat cagccatcag cctgtcaact cagttaacaa gttaaggacc     2400

gaagtgtttc aagtggatct cagtaaagga tctttggagc c                         2441


<210> 3002
<211> 1638
<212> DNA
<213> Homo sapiens

<400> 3002
gtttgtctgc cggactgacg ggcggccggg cggtgcgcgg cggcggtggc ggcggggaag       60

atggcggcgt cctccctgga acagaagctg tcccgcctgg aagcaaagct gaagcaggag      120

aaccgggagg cccggcggag gatcgacctc aacctggata tcagccccca gcggcccagg      180

cccattattg tgatcactct aagccctgct cctgccccgt cccaacgagc agccctgcag      240

ctcccgctgg ccaacgatgg gggcagccgc tcgccatcct cagagagctc cccgcagcac      300

cccacgcccc ccgcccggcc ccgccacatg ctggggctcc cgtcaaccct gttcacaccc      360

cgcagcatgg agagcattga gattgaccag aagctgcagg agatcatgaa gcagacgggc      420

tacctgacca tcgggggcca gcgctaccag gcagaaatca acgacctgga gaacttgggc      480

gagatgggca gcggcacctg cggccaggtg tggaagatgc gcttccggaa gaccggccac      540

gtcattgccg ttaagcaaat gcggcgctcc gggaacaagg aggagaacaa gcgcatcctc      600

atggacctgg atgtggtgct gaagagccac gactgcccct acatcgtgca gtgctttggg      660

acgttcatca ccaacacgga cgtcttcatc gccatggagc tcatgggcac ctgcgctgag      720

aagctcaaga agcggatgca gggccccatc cccgagcgca ttctgggcaa gatgacagtg      780

gcgattgtga aggcgctgta ctacctgaag gagaagcacg gtgtcatcca ccgcgacgtc      840

aagccctcca acatcctgct ggacgagcgg ggccagatca agctctgcga cttcggcatc      900

agcggccgcc tggtggactc caaagccaag acgcggagcg ccggctgtgc cgcctacatg      960

gcacccgagc gcattgaccc cccagacccc accaagccgg actatgacat ccgggccgac     1020

gtatggagcc tgggcatctc gttggtggag ctggcaacag gacagtttcc ctacaagaac     1080

tgcaagacgg actttgaggt cctcaccaaa gtcctacagg aagagccccc gcttctgccc     1140

ggacacatgg gcttctcggg ggacttccag tccttcgtca aagactgcct tactaaagat     1200

cacaggaaga gaccaaagta taataagcta cttgaacaca gcttcatcaa gcgctacgag     1260

acgctggagg tggacgtggc gtcctggttc aaggatgtca tggcgaagac tgagtcaccg     1320

cggactagcg gcgtcctgag ccagccccac ctgcccttct tcaggtagct gcttggcggc     1380

ggccagcccc acagggggcc aggggcatgg ccacaggccc ccctccccac ttggccaccc     1440

agctgcctgc cccttggccc ctttgtcagg ggccaggggt ctgccgggtg ggggtgccaa     1500

caggcctggc cctttcctcc cctgcatcca gccatggggg cctctgcgat tgccggaagg     1560

ttgcatggct ggtcccaggg ccagcacagg cccgaggccg ggctgcctgg ttttattttt     1620

atttaacttt attttctg                                                   1638


<210> 3003
<211> 3006
<212> DNA
<213> Homo sapiens

<400> 3003
atggcttcca gtccgctgcc agggcccaac gacatcctgc tggcgtcgcc gtcgagcgcc       60

ttccagcccg acacgctgag ccagccgcgg ccagggcacg ccaacctcaa acccaaccag      120

gtgggccagg tgatcctcta cggcattccc atcgtgtcgt tggtgatcga cgggcaagag      180

cgcctgtgcc tggcgcagat ctccaacact ctgctcaaga acttcagcta caacgagatc      240

cacaaccgtc gcgtggcact gggcatcacg tgtgtgcagt gcacgccggt gcaactggag      300

atcctgcggc gtgccggggc catgcccatc tcatcgcgcc gctgcggcat gatcaccaaa      360

cgcgaggccg agcgtctgtg caagtcgttc ctgggcgaaa acaggccgcc caagctgcca      420

gacaatttcg ccttcgacgt gtcacacgag tgcgcctggg gctgccgcgg cagcttcatt      480

cccgcgcgct acaacagctc gcgcgccaag tgcatcaaat gcagctactg caacatgtac      540

ttctcgccca acaagttcat tttccactcc caccgcacgc ccgacgccaa gtacactcag      600

ccagacgcag ccaacttcaa ctcgtggcgc cgtcatctca agctcaccga caagagtccc      660

caggacgagc tggtcttcgc ctgggaggac gtcaaggcca tgttcaacgg cggcagccgc      720

aagcgcgcac tgccccagcc gggcgcgcac cccgcctgcc acccgctcag ctctgtgaag      780

gcggccgccg tggccgccgc ggccgcggtg gccggaggcg ggggtctgct gggcccccac      840

ctgctgggtg cgcccccgcc gccgccgccg ccaccgccgc ccttggcaga gctggctggt      900

gccccgcacg cccatcacaa gcggccgcgc ttcgacgacg acgacgactc cttgcaggag      960

gccgccgtag tggccgccgc cagcctctcg gccgcagccg ccagcctctc tgtggctgct     1020

gcttcgggcg gcgcggggac tggtgggggc ggcgctgggg gtggctgtgt ggccggcgtg     1080

ggcgtgggcg cgggcgcggg ggcgggtgcc ggggcagggg ccaaaggccc gcgcagctac     1140

ccagtcatcc cggtgcccag caagggctcg ttcgggggcg tcctgcagaa gttcccgggc     1200

tgcggcgggc tcttcccgca cccctacacc ttccctgccg cggccgccgc cttcagcttg     1260

tgccataaga aagaggatgc gggtgccgcc gctgaggccc tggggggcgc gggcgcaggc     1320

ggcgcgggcg cggcgcccaa ggccggcttg tccggcctct tctggcccgc gggccgcaag     1380

gacgccttct atccgccctt ctgcatgttc tggccgccgc ggacccctgg cgggctcccg     1440

gtgcccacct acctgcagcc cccgcctcag ccgccctcgg cgctaggctg cgcgctaggc     1500

gaaagcccgg ccctgctgcg ccaggccttc ctggacctgg ctgagccagg cggtgctgct     1560

gggagcgccg aggccgcgcc cccgccgggg cagcccccgc aggtagtggc caacggcccg     1620

ggctccggcc cacctcctcc tgccgggggc gccggctctc gcgacgcgct cttcgagtcg     1680

cccccgggcg gcagcggcgg ggactgcagc gcgggctcca cgccgcccgc ggactctgtg     1740

gcagctgccg gggcaggggc cgcggccgcc gggtctggcc ccgcgggctc ccgggttccg     1800

gcgccccacc atccgcacct tctggagggg cgcaaagcgg gcggtggcag ctaccaccat     1860

tccagcgcct tccggccagt gggcggcaag gacgacgcgg agagcctggc caagctgcac     1920

ggggcgtcgg cgggcgcgcc ccactcggcc cagacgcatc cccaccacca tcaccaccct     1980

caccaccacc accaccacca ccaccccccg cagccgccgt cgccgcttct gctgctgccc     2040

ccgcagcccg acgagccggg ttccgagcgc caccacccgg ccccgccgcc gccgccgccg     2100

ccgcccccgc cgccccctct ggcccagcac ccgcaccacc gaggccttct gtctcccggg     2160

ggaaccagct gctgctaccc cagcgaggac agctccgagg acgaggacga cgaggaagaa     2220

gagcaggagg tggacgtgga gggccacaag ccccccgagg gcgaggaaga ggaggaaggt     2280

cgagaccctg acgacgacga ggaagaggac gaggagacgg aggtcctact cggcgacccc     2340

ttagtcgggg gcggccggtt cctccagggc cgagggccgt cggagaaggg gagcagccgg     2400

gaccgcgcgc cggccgtcgc gggcgcgttc ccgctcggcc tgaactcctc caggctgctg     2460

caggaagacg ggaaactcgg ggaccccggc tcggacctgc ccccgccccc gccgccgccc     2520

ctggcccccc agaaggcgag tggcggcggc agcagcagcc cgggcagccc agttcaccat     2580

ccatcactgg aggagcagcc ctcctacaaa gatagtcaga aaactaagga aaataaccaa     2640

gtaattgtat ctacaaagga tgacaacagc ttttcagata agaacaagga gcatagcttt     2700

ttcatcacag actctgatgc ttctggagga gatttttgga gagaaagatc aggtgaacat     2760

acacaagaaa ccaactcacc tcattcactg aaaaaggatg tagaaaatat ggggaaagaa     2820

gaacttcaga aggttttatt tgaacaaata gatttacgga gacgactgga acaagaattc     2880

caggtgttaa aaggaaacac atctttccca gtattcaata attttcagga tcagatgaaa     2940

agggagctag cctaccgaga agaaatggtg caacagttac aaattgtaag ctgcatttct     3000

acttaa                                                                3006


<210> 3004
<211> 566
<212> DNA
<213> Homo sapiens

<400> 3004
atgcgcagcg gctcgctcgg aagctgcgac gccgagtttc actctggctg ccttctcctg       60

agagtcggag ccacagccag agccctgccc aggccgagcc ggagctgcag cccgagcgcg      120

gtggtgccct cagccccgtc ctcttgtcct cctcagcctc ggagctggtg tcttcatcca      180

gaagggacag tttgtgccag ctctccagag agaaaagaaa cttccaattg aagacactga      240

gctgaaccat tccgcccgcc cgcccgcccg agggcactcc agatctgccg gaggcgctgg      300

gcaatgaccc cgggactcca ggccagaggg gtctgaagct gtttgggaaa gcagcgggac      360

tccttgggaa gatggccatg gccccaagcc cttccctggt gcaggtgtac accagccccg      420

cggctgtggc cgtgtgggaa tggcaggacg ggctgggcac ctggcacccc tacagtgcca      480

ccgtctgcag cttcatcgag cagcagtttg tccagcagaa gggccaacgt tttgggcttg      540

ggagcctggc ccacagcatc cccttg                                           566


<210> 3005
<211> 1552
<212> DNA
<213> Homo sapiens

<400> 3005
acccgcaccc tcggcggccg cagcctcagc accgcagagc ggagagcgga gcccggagcc       60

cgccgcccca gtgcacttac atttcaatcg accaagttcc aaggacctat gccataatga      120

taagcagacc cgcctggctc tggggagcag aaatgggagc caatgaacat ggagtgtgca      180

tagccaatga agccatcaac accagagagc cagctgccga gatagaagcc ttgctgggga      240

tggatctggt caggcttggt ttagaaagag gggaaacagc taaagaagcc ttagatgtca      300

ttgtctcctt gttggaagaa catggacaag gtgggaatta ctttgaagat gcaaactcct      360

gccacagctt ccaaagtgca tatctgattg tggatcgtga tgaagcctgg gtgctcgaga      420

ccatagggaa gtactgggct gccgagaaag tcacagaggg agtgaggtgc atttgcagtc      480

agctttcgct caccactaag atggatgcag agcatccgga actcaggagt tacgctcaga      540

gccaaggttg gtggacggga gagggcgagt tcaatttttc cgaagtcttt tctccagttg      600

aggatcatct agactgcggt gctggcaaag acagcttaga aaaacaagaa gaaagcatca      660

cagtgcagac tatgatgaac accttacggg acaaagccag cggagtgtgc atagactctg      720

agtttttcct caccacagcc agtggagtgt ctgtcctgcc gcagaataga agctctccgt      780

gcattcacta cttcactgga acccctgatc cttccaggtc catattcaag cctttcatct      840

ttgttgatga cgtaaaactt gtccccaaaa cacagtctcc ctgttttggg gatgacgacc      900

ctgccaaaaa ggagcctcgg ttccaggaga aaccagaccg ccggcatgag ctgtacaaag      960

cccacgagtg ggcacgtgcc atcatcgaaa gtgaccagga gcaaggtcgc aagctgagga     1020

gcaccatgct ggagctggag aagcaaggcc tggaagccat ggaagaaatc ctgaccagct     1080

ccgagccact ggaccctgcg gaagtggggg accttttcta tgactgtgtt gacacggaga     1140

ttaagttctt taagtgaagt aagcgttccc tttccccttc ttatttaaga cttcccacct     1200

tactaaatta ccagcaaaac aaaccactct cctgtttgag taaaatgaga aagttaatat     1260

gtggcctcct tttctgaagc cagatcaaac tgttaccttg tgttccacct tgaatctcac     1320

agcgtcccct tctgcaatgt aggtctcctt cctgtgcagt gtaacatgta tcccgttgcc     1380

tgttgttcgg ttgtgtgact aattgtggat tttaagctgc tattattgta tttcagtggc     1440

aatggacaca ttagcctttt acaagaggac tagagttcat caagccttga aaggcaggct     1500

tcacagtgcc gagttggcgg gaaaagcaaa ttcttttgaa gtcttagtct tt             1552


<210> 3006
<211> 3227
<212> DNA
<213> Homo sapiens

<400> 3006
ggccgggatt cgcggcccgg agctcgggac cggttgcttc attccagcct cgcagtcacc       60

tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt gccttccatg gatctatagg      120

agagcaagtc ctccaggaga agaagtcctc accagtgaac ggagacctct ctgaactaag      180

gataccatgg ccacgtcagc cccactacgg agcctggaag aggaggtgac ctgctccatc      240

tgtcttgatt acctgcggga ccctgtgacc attgactgtg gccacgtctt ctgccgcagc      300

tgcaccacag acgtccgccc catctcaggg agccgccccg tctgcccact ctgcaagaag      360

ccttttaaga aggagaacat ccgacccgtg tggcaactgg ccagcctggt ggagaacatt      420

gagcggctga aggtggacaa gggcaggcag ccgggagagg tgacccggga gcagcaggat      480

gcaaagttgt gcgagcgaca ccgagagaag ctgcactact actgtgagga cgacgggaag      540

ctgctgtgcg tgatgtgccg ggagtcccgg gagcacaggc cccacacggc cgtcctcatg      600

gagaaggccg cccagcccca cagggaaaaa atcctgaacc acctgagtac cctaaggagg      660

gacagagaca aaattcaggg cttccaggca aagggagaag ctgatatcct ggccgcgctg      720

aagaagctcc aggaccagag gcagtacatt gtggctgagt ttgagcaggg tcatcagttc      780

ctgagggagc gggaggaaca cctgctggaa cagctggcga agctggagca ggagctcacg      840

gagggcaggg agaagttcaa gagccggggc gtcggggagc ttgcccggct ggccctggtc      900

atctccgaac tggagggcaa ggcgcagcag ccagctgcag agctcatgca ggacacgaga      960

gacttcctaa acaggtatcc acggaagaag ttctgggttg ggaaacccat tgctcgagtg     1020

gttaaaaaaa agaccggaga attctcagat aaactcctct ctctgcaacg aggcctgagg     1080

gaattccagg ggaagctgct gagagacttg gaatataaga cagtgagcgt caccctggac     1140

ccacagtcgg ccagtgggta cctgcagctg tcagaggact ggaagtgcgt gacctacacc     1200

agcctgtaca agagtgccta cctgcacccc cagcagtttg actgtgagcc tggggtgctg     1260

ggcagcaagg gcttcacctg gggcaaggtc tactgggaag tggaagtgga gagggagggc     1320

tggtctgagg atgaagaaga gggggatgag gaggaagagg gagaagagga ggaggaggaa     1380

gaggaggccg gctatgggga tggatatgac gactgggaaa cggacgaaga tgaggaatcg     1440

ttgggcgatg aagaggaaga agaggaggag gaagaggagg aagttctgga aagctgcatg     1500

gtgggggtgg ctagagactc tgtgaagagg aagggagacc tctccctgcg gccagaggat     1560

ggcgtgtggg cgctgcgcct ctcctcctcc ggcatctggg ccaacaccag ccccgaggct     1620

gagcttttcc cagcactgcg gccccggaga gtgggcatcg ccctggatta tgaagggggc     1680

accgtgactt tcaccaacgc agagtcacag gaactcatct acaccttcac tgccaccttc     1740

acccggcgcc tggtcccctt cctgtggctc aagtggccag gaacacgcct cctgctaaga     1800

ccctgagccc tgacatctgc ccccagcccc aaccctcaga tgcttcactt ctttggaatt     1860

ccaggactct caatgggggg acgggatgcc tggcctaagc acctggagca ggggacccca     1920

tatccactgg tagccacctc cccattgctg tggccccctg aaatctcact cagtgctgtt     1980

gctccatcta ctgccctaat ggggctcttt tcccacctcc tgctggtttc ccgagggaac     2040

ttctgaccct ggagtccatg agggctcctt tcctttttga ccacgacctt ggccccagct     2100

ctgcactctc tggaataagg gcccgatgca gcattttctt gcccagtgtg gcaagacctc     2160

agaaaaacca gtcaattacg cctaagatca ttttgctgtc cttaaacccc ccaggttcct     2220

tcttgcacaa atccactctg ctgcccacct tccctggcat tttaaacaga cctaccccac     2280

cccaactcag agttaagcat acatggcaat gctgaaaata aacaaaatcc actgaggctt     2340

cccaggccat ttaaagcctg gagtaccagc gcatatcatc tcatggggtc cagagtggag     2400

tccaggcttc tctgaaacca gggctgagca tatttccata gccaaggagg tgggactccc     2460

tggagctatc tgtggtctta gggaaggatc cagacataca cggctttggg gtacaagctg     2520

tgatcactga tcaataaatt atctctagat tggtccttgt gaggggagtt ttaagaatcc     2580

agaacatctt gctcttgatc agcacatcca aaaacaccaa gacaaacatc cagtggagca     2640

gaacctctcc tgcctcggga gttctgacca ggttccccag cagggtgtta agcctctgtc     2700

tctggcccta ccagcatcca ggttccactt tcctaggaga gagtggagat gggaagacag     2760

ggaaaggaag gcagcaggag gccacaagcc caccaggtct tcatgtcaag agagggagta     2820

acatgtcttc tcattgccca cggacccaac ctctgtccag gtgcccctca tcatcacagt     2880

ttaacacaag ctcccctgct ccagccaaat tgatctccca gtcttgtcct tacccattcc     2940

aagtgctctg ccagcccctg ttcatccaag ttttaagtcc tccaccctgt tctaagagac     3000

tgttccaacg gctctgggcc tcagtggtca cttgaccacc attgtctcag agctgcccac     3060

tttgtgtgtg tcacatgctg cctgagtcac acgtacatct tatttctgcc tctagttttg     3120

taagctcctg gagggcggat aacatcttat actactcttg tattctcatg gcacctagtg     3180

cagtgctggg cacagagtag gtgctcaata aagacttgtt gaatgaa                   3227


<210> 3007
<211> 740
<212> DNA
<213> Homo sapiens

<400> 3007
gggtttatta ctactgaagg aagaacgtga gtaggttagg atttcggttg agaggcttgg       60

ggtcttgcgt ttcgcccacc atctcctggg gacagggtgg agtcgatatc cgggacgggg      120

gggaggttgc ggtgcccctc agggctacct ctcaagagtg ctatcatttc cgcaggccag      180

atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac      240

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      300

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      360

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      420

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      480

ggccacagta gggaagaggc tggactatat cacagctgaa attaagcgat acgaatccca      540

gcttcgggat cttgagcggc agtcagagca acagagggag acccttgctc agctgcagca      600

ggagttccag cgggcccagg cagcaaaggc aggggctcct ggcaaggcct gaccccatgg      660

tggggggagg ggaggggagg ggagggaatg aggcagctct aggatctata ctgtagctaa      720

taaaatgtaa aaacacctgg                                                  740


<210> 3008
<211> 3821
<212> DNA
<213> Homo sapiens

<400> 3008
ctcagcctgg cggttctacc tccgagggtt cgcccgccct tggttttcct tacaccttag       60

cctttggctc ctttgaccac tcgaagcccc acagcgtgtt ccagcggact tcaccagcag      120

acccagaagt ggtgggtgaa acactgcctc tgttcctcct tgagcctgtc gggagctgct      180

gcctgccacc accatgtctg ctgcaaatcc tgagactcca aactcaacca tctccagaga      240

ggccagcacc cagtcttcat cagctgcagc tagccaaggc tgggtgttac cagaaggcaa      300

aatcgtgcca aacactgttt ttgttggtgg aattgatgct aggatggatg aaactgagat      360

tggaagctgc tttggtagat acggttcagt gaaagaagtg aagataatca cgaatcgaac      420

tggtgtgtcc aaaggctatg gatttgtttc gtttgttaat gacgtggatg tccagaagat      480

agtaggatca cagatacatt tccatggtaa aaagctgaag ctgggccctg caatcaggaa      540

acaaaagtta tgtgctcgtc atgtgcagcc acgtcctttg gtagttaatc ctcctcctcc      600

accacagttt cagaacgtct ggcggaatcc aaacactgaa acctacctgc agccccaaat      660

cacgccgaat cctgtaactc agcacgttca gtctgctgca aatcctgaga ctccaaactc      720

aaccatctcc agagaggcca gcacccagtc ttcatcagct gcagctagcc aaggctgggt      780

gttaccagaa ggcaaaatcg tgccaaacac tgtttttgtt ggtggaattg atgctaggat      840

ggatgaaact gagattggaa gctgctttgg tagatacggt tcagtgaaag aagtgaagat      900

aatcacgaat cgaactggtg tgtccaaagg ctatggattt gtttcgtttg ttaatgacgt      960

ggatgtccag aagatagtag gatcacagat acatttccat ggtaaaaagc tgaagctggg     1020

ccctgcaatc aggaaacaaa agttatgtgc tcgtcatgtg cagccacgtc ctttggtagt     1080

taatcctcct cctccaccac agtttcagaa cgtctggcgg aatccaaaca ctgaaaccta     1140

cctgcagccc caaatcacgc cgaatcctgt aactcagcac gttcaggctt actctgctta     1200

tccacattca ccaggtcagg tcatcactgg atgtcagttg cttgtatata attatcagga     1260

atatcctact tatcccgatt cagcatttca ggtcaccact ggatatcagt tgcctgtata     1320

taattatcag ccatttcctg cttatccaag atcaccattt caggtcactg ctggatatca     1380

gttgcctgta tataattatc aggcatttcc tgcttatcca aattcaccat ttcaagtcgc     1440

cactggatat cagttccctg tatacaatta tcagccattt cctgcttatc caagttcacc     1500

atttcaggtc actgctggat atcagttgcc tgtatataat tatcaggcat ttcctgctta     1560

tccaaattca ccatttcaag tcgccactgg atatcagttc cctgtataca attatcaggc     1620

atttcctgct tatccaaatt caccagttca ggtcaccact ggatatcagt tgcctgtata     1680

caattatcag gcatttcctg cttatccaag ttcaccattt caggtcacca ctggatatca     1740

gttgcctgta tataattatc aggcatttcc tgcttatcca aattcagcag ttcaggtcac     1800

cactggatat cagttccatg tatacaatta ccagatgcca ccgcagtgcc ctgttgggga     1860

gcaaaggaga aatctgtgga ccgaagcata caaatggtgg tatcttgtct gtttaatcca     1920

gagaagagac tgataaattc cgttgttact caagatgact gcttcaaggg taaaagagtg     1980

catcgcttta gaagaagttt ggcagtattt aaatctgttg gatcctctca gctatctagt     2040

ttcatgggaa gttgctggtt ttgaatatta agctaaaagt tttccactat tacagaaatt     2100

ctgaattttg gtaaatcaca ctgaaacttt ctgtataact tgtattatta gactctctag     2160

ttttatctta acactgaaac tgttcttcat tagatgttta tttagaacct ggttctgtgt     2220

ttaatatata gtttaaagta acaaataatc gagactgaaa gaatgttaag atttatctgc     2280

aaggattttt aaaaaattga aacttgcatt ttaagtgttt aaaagcaaat actgactttc     2340

aaaaaagttt ttaaaacctg atttgaaagc taacaatttt gatagtctga acacaagcat     2400

ttcacttctc caagaagtac ctgtgaacag tacaatattt cagtattgag ctttgcattt     2460

atgatttatc tagaaattta cctcaaaagc agaattttta aaactgcatt tttaatcagt     2520

ggaactcaat gtatagttag ctttattgaa gtcttatcca aacccagtaa aacagattct     2580

aagcaaacag tccaatcagt gagtcataat gtttattcaa agtattttat cttttatcta     2640

gaatccacat atgtatgtcc aatttgattg ggatagtagt taggataact aaaattctgg     2700

gcctaatttt ttaaagaatc caagacaaac taaactttac tgggtatata accttctcaa     2760

tgagttacca ttctttttta taaaaaaaat tgttccttga aatgctaaac ttaatggctg     2820

tatgtgaaat ttgcaaaata ctggtattaa agaacgctgc agctttttta tgtcactcaa     2880

aggttaatcg gagtatctga aaggaattgt ttttataaaa acattgaagt attagttact     2940

tgctataaat agatttttat ttttgttttt tagcctgtta tatttccttc tgtaaaataa     3000

aatatgtcca gaagaggcat gttgtttcta gattaggtag tgtcctcatt ttatattgtg     3060

accacacagc tagagcacca gagccctttt gctatactca cagtcttgtt ttcccagcct     3120

cttttactag tctttcagga ggtttgctct tagaactggt gatgtaaaga atggaagtag     3180

ctgtatgagc agttcaaagg ccaagccgtg gaatggtagc aatgggatat aatacctttc     3240

taagggaaac atttgtatca gtatcatttg atctgccatg gacatgtgtt taaagtggct     3300

ttctggccct tctttcaatg gcttcttccc taaaacgtgg agactctaag ttaatgtcgt     3360

tactatgggc catattacta atgcccactg gggtctatga tttctcaaaa ttttcattcg     3420

gaatccgaag gatacagtct ttaaacttta gaattcccaa gaaggcttta ttacacctca     3480

gaaattgaaa gcaccatgac tttgtccatt aaaaaattat ccatagtttt tttagtgctt     3540

ttaacattcc gacatacatc attctgtgat taaatctcca gatttctgta aatgatacct     3600

acattctaaa gagttaattc taattattcc gatatgacct taaggaaaag taaaggaata     3660

aatttttgtc tttgttgaag tatttaatag agtaaggtaa agaagatatt aagtcccttt     3720

caaaatggaa aattaattct aaactgagaa aaatgttcct actacctatt gctgatactg     3780

tctttgcata aatgaataaa aataaacttt ttttcttcaa a                         3821


<210> 3009
<211> 3107
<212> DNA
<213> Homo sapiens

<400> 3009
aaaaacgaaa gaagcccaca gttgggacga ggattccagt tttgcgtcac cgtcaaggcg       60

ggaaagttcc cggctgtcgg ttggagggtg ggtcctcgcc ccgccccgcc ccctcgggcc      120

gcccttccgc gcttccggga ggcttgtccc aagctcacgg acccctcgct gggtgccggt      180

taagaccccg ctccccgtcg ccagtgctat ggaggcggcg gcggcggtgg tggcggcaga      240

ggcggaagtg gaaaacgaag acggcgacag cagctgcggg gatgtatgct tcatggacaa      300

aggcttgcag aggacttgaa gaactaatta atctgactag actaaatgta tcttataacc      360

acatagatga tcttagtgga ttgattcccc ttcatggaat taagcataaa cttagatata      420

ttgatctaca tagtaatcgt atagatagta tccatcactt acttcagtgt atggtaggat      480

tgcacttcct gaccaatctt attttggaga aagatggaga cgataatcct gtctgtcgac      540

tgccagggta cagagcagtt attctccaga ctttgccaca gcttagaatc ctagattgca      600

agaacatatt tggtgaacca gtaaatttga cagaaataaa ttcatcacag ctgcagtgcc      660

tagaaggtct tttggataat ttagtttctt ctgattctcc cctaaatata agtgaagatg      720

agatcattga tagaatgcca gtgataacag cacctatcga tgagttagtt cccttggaac      780

agtttgcaag tacaccaagt gatgctgtgt tgacgtcttt tatgtctgtg tgtcaatctt      840

ctgagccaga gaaaaataat catgaaaacg atttgcagaa tgagataaaa cttcagaaat      900

tagatgacca aattctacaa cttctaaatg aaacttctaa ttcaatagat aacgttcttg      960

agaaagaccc cagaccaaaa agagacacag atataacttc tgaaagtgac tatggaaaca     1020

gtagaaaaaa tggagagaca aaaaaggcag cagcaggcag cacagataag actgatccaa     1080

gaggtggaac tcaaagcttc agctgccgat agagaaatat acttacttag aacttccctt     1140

catcgagaaa gagaacaagc gcaacaactt catcaacttc ttgcattgaa agaacaggaa     1200

cacaggaagg aacttgaaac aagggagttt tttactgatg ctgacttcca ggatgcctta     1260

gctaaagaaa tagccaaaga agagaaaaag catgagcaaa tgataaaaga ataccaagag     1320

aaaattgacg tgttaagcca gcagtatatg gatttagaaa atgaattccg tattgcttta     1380

actgttgaag ccagaagatt tcaagatgtt aaagatggtt ttgaaaatgt tgcaactgag     1440

ttagcaaaga gcaaacatgc tcttatttgg gctcaacgaa aagaaaatga gtcttcctct     1500

ttaattaaag atctgacctg tatggtaaag gaacaaaaaa caaaactggc agaagtttct     1560

aaattgaaac aagaaacagc agcaaattta cagaatcaaa tcaacaccct tgaaatttta     1620

attgaagatg acaagcagaa gagtattcaa atagaacttc tcaagcacga aaaagtccag     1680

cttatttctg agctagcagc caaggaatca ctaatatttg gtttaaggac agaaagaaaa     1740

gtatggggac atgagctggc acaacaagga tcttctctag cccaaaatcg tggaaaattg     1800

gaggctcaaa ttgagagttt atctagagag aatgaatgtc tgcgaaagac aaatgaaagt     1860

gatagtgatg cattaagaat aaagtgcaaa atcatagacg accaaactga aactattaga     1920

aaattaaaag attgtttaca agaaaaagat gaacacatca aaagattaca agaaaagatc     1980

acagaaatag aaaaatgcac tcaagaacaa cttgatgaaa aatcttcaca actggatgag     2040

gtacttgaga agttggaaag gcacaatgaa agaaaagaaa aactaaaaca acagttgaaa     2100

ggaaaggaag tagaacttga agaaatcaga aaagcttaca gtacactgaa tcggaagtgg     2160

catgataaag gagaacttct atgtcatctt gaaacacaag taaaagaagt gaaagaaaaa     2220

tttgaaaaca aggaaaagaa acttaaagcg gaaagagaca aaagtattga actacaaaag     2280

aatgcaatgg aaaaacttca tagtatggat gatgccttta aaagacaagt tgatgcaatt     2340

gttgaagctc atcaagctga aatagcacag ctggccaatg aaaagcagaa gtgtattgat     2400

tctgcaaatt taaaggtcca tcaaattgaa aaagaaatgc gtgaactttt ggaagaaaca     2460

tgcaagaaca aaaaaacaat ggaagcaaaa attaagcaac ttgcttttgc tttaaatgaa     2520

attcagcaag atatgtgatg gttctgagaa tgaatttaat tgaaatagac cagcagacct     2580

attgtaaaaa tgattaaata ttgtaatagt agtaactgct atgactttga aatgtctctt     2640

tctatacatt tcattatgaa tatattttta aagacttttg atcaagtatt tattaattgt     2700

ataggttttt tataataaat tgttgacaat tttgtctatt agaaaaaact atcataacta     2760

gacttacaat atttttcttg tttctgtact atacattgtt tggtaattac acatttgcct     2820

acaaatttgt gaatgaaaag attagtattt tcaccatatg aggtaaaaca ttttaatcat     2880

tgttatctta ttgtgatgat gaagaactaa ttatatttgt tatttaattg atgtagctca     2940

attcttttaa agtacttatg tagccaaaaa gcatttgaaa tctgtatgat aaaagatgtg     3000

gcattcttaa gaaagtatat gtagccatct ccacatcact cattatgacc ccttctttta     3060

taatgcttat atcttttcat taaagattac atttaaggtt ttataaa                   3107


<210> 3010
<211> 2757
<212> DNA
<213> Homo sapiens

<400> 3010
gagcggcgac ggcggcggcg gcgggcacag attaattaaa agaagaatga actataatcc       60

ttgaagataa ctgggcaatt ttttaagtcg gaggctgttc ttactggtgt gaggatttac      120

acacgtcttc agtttttcag cacagaccag cagaccatca tttttagagg aaatactccc      180

tctgccctcc tttttggttt ccttggtggg ctcaactaaa aaactgaatg ggatgggaga      240

tgatggcagc cccccagcga aaaaaatgat aacggacatt catgcaaatg gaaaaacgat      300

aaacaaggtg ccaacagtta agaaggaaca cttggatgac tatggagaag caccagtgga      360

aactgatgga gagcatgtta agcgaacctg tacttctgtt cctgaaactt tgcatttaaa      420

tcccagtttg aaacacacat tggcacaatt ccatttaagt agtcagagct cgctgggtgg      480

accagcagca ttttctgctc ggcattccca agaaagcatg tcgcctactg tatttctgcc      540

tcttccatca cctcaggttc ttcctggccc attgctcatc ccttcagata gctccacaga      600

actcactcag actgtgttgg aaggggaatc tatttcttgt tttcaagttg gaggagaaaa      660

gagactctgt ttgccccaag tcttaaattc tgttctccga gaatttacac tccagcaaat      720

aaatacagtg tgtgatgaac tgtacatata ttgttcaagg tgtacttcag accagcttca      780

tatcttaaag gtactgggca tacttccatt caatgcccca tcctgtgggc tgattacatt      840

aactgatgca caaagattat gtaatgcttt attgcggcca cgaacttttc ctcaaaatgg      900

tagcgtactt cctgctaaaa gctcattggc ccagttaaag gaaactggca gtgcctttga      960

agtggagcat gaatgcctag gcaaatgtca gggtttattt gcaccccagt tttatgttca     1020

gcctgatgct ccgtgtattc aatgtctgga gtgttgtgga atgtttgcac cccagacgtt     1080

tgtgatgcat tctcacagat cacctgacaa aagaacttgc cactggggct ttgaatcagc     1140

taaatggcat tgctatcttc atgtgaacca aaaatactta ggaacacctg aagaaaagaa     1200

actgaagata attttagaag aaatgaagga gaagtttagc atgagaagtg gaaagagaaa     1260

tcaatccaag acagatgcac catcaggaat ggaattacag tcatggtatc ctgttataaa     1320

gcaggaaggt gaccatgttt ctcagacaca ttcattttta caccccagct actacttata     1380

catgtgtgat aaagtggttg ccccaaatgt gtcacttact tctgctgtat cccagtctaa     1440

agagctcaca aagacagagg caagtaagtc catatcaaga cagtcagaga aggctcacag     1500

tagtggtaaa cttcaaaaaa cagtgtctta tccagatgtc tcacttgagg aacaggagaa     1560

aatggattta aaaacaagta gagaattatg tagccgttta gatgcatcaa tctcaaataa     1620

ttctacaagt aaaaggaaat ctgagtctgc cacttgcaac ttagtcagag acataaacaa     1680

agtgggaatt ggccttgttg ctgccgcttc atctccgctt cttgtgaaag atgtcatttg     1740

tgaggatgat aagggaaaaa tcatggaaga agtaatgaga acttatttaa aacaacagga     1800

aaaactaaac ttgattttgc aaaagaagca acaacttcag atggaagtaa aaatgttgag     1860

tagttcaaaa tctatgaagg aactcactga agaacagcag aatttacaga aagagcttga     1920

atctttgcag aatgaacatg ctcaaagaat ggaagaattt tatgttgaac agaaagactt     1980

agagaaaaaa ttggagcaga taatgaagca aaaatgtacc tgtgactcaa atttagaaaa     2040

agacaaagag gctgaatatg caggacagtt ggcagaactg aggcagagat tggaccatgc     2100

tgaggccgat aggcaagaac tccaagatga actcagacag gaacgggaag caagacagaa     2160

gttagagatg atgataaaag agctaaagct gcaaattctg aaatcatcaa agactgctaa     2220

agaatagaaa ctgttaaaga gattcatctg tgtattactg acaaggtttt ttttgtttgt     2280

tgcttgcttt ggtaattgaa ttctgaagaa tttatctgca tgacgataac taggcattct     2340

atccatttgt agatcagaga aagtgaagag attatatatt agtacttaaa tttttacatt     2400

ttccaaatga atgaaaatgt atgtttcttt gtactttttt aaaaaaatca gcttagtaac     2460

aatactatat ggtttcaact agtaggtaat ctgcttatat ttctaatgca aacttaacaa     2520

ttgtgtactt tttaaaagct gcaatatgtg ttggaaaata gctgtggtca attttgttat     2580

ccatatttca gactcaattt tagatacaat ggtggcttta tattttaagt atatagagct     2640

actcaaggag ttgaatctcc ccttttctca ttaacacaat ttttctaagt tgatatggtg     2700

tactcattaa catacaccaa atttactttt actttgttca gattgtggaa tgaattt        2757


<210> 3011
<211> 1435
<212> DNA
<213> Homo sapiens

<400> 3011
agggctaggg gaggatggcg aggagatggg taggagagac ctggtgtctg gaggaagcaa       60

tgaaggaaat gggaaggaag actgggccat gaaaacagtg tccttgcgtt ggacaaagct      120

gcccccggtg aagtctgcca tccgtgggca agctcctgtg gtaccctaca tgcgctatgg      180

acactcaacc gtcctcatcg acgacacagt cctcctttgg ggcgggcgga atgacaccga      240

aggggcctgc aatgtgctct atgcctttga cgtcaatacg cacaagtggt tcacaccccg      300

agtgtcaggg acagttcctg gggcccggga tggacattca gcctgtgtcc taggcaagat      360

catgtacatt tttgggggct acgagcagca ggcggactgt ttttccaatg acattcacaa      420

gctagatacc agcaccatga catggactct tatctgtaca aagggcagcc ctgcacgctg      480

gagggacttc cactcagcca caatgctggg aagtcacatg tatgtctttg ggggccgtgc      540

cgaccgcttt gggccattcc attccaacaa tgagatttac tgcaaccgca ttcgagtctt      600

tgacaccaga actgaggctt ggctggactg tcccccgact ccagtgctgc ctgaggggcg      660

ccggagccac tcggcctttg gctacaatgg ggagctgtac atctttggtg gttataatgc      720

aaggctgaac cggcacttcc atgacctctg gaagtttaat cctgtgtcct ttacctggaa      780

aaagattgaa ccgaagggga aggggccatg tccccgccgg cgccagtgct gctgtattgt      840

tggtgacaag attgtcctct ttgggggtac cagtccatct cctgaggaag gcctgggaga      900

tgaatttgac cttatagatc attctgactt acacattttg gactttagcc ctagtctgaa      960

gactctgtgc aaactggccg tgattcagta taacctagac cagtcctgtt tgcctcatga     1020

tatcaggtgg gagctgaatg ccatgaccac caacagcaat atcagtcgcc ccatcgtctc     1080

ctcccatggg taggaggaag tttctgccac ctcccctcct gagcctgctg tcatcttcac     1140

tgcccctgcc catctgtcac ccacctgctc ctttgacccc tggacttggt atacctccat     1200

gtggagttgt tgggcgagag gtgttctctg tgctgtgaat tcagtgggga gctgtagcgg     1260

ggtgggggct aggttcctcc ccccttgggc cgagggcccc ttccccttgg tgctctgtcc     1320

ccatccacct cctttcagct gctcctgggc ctcagctctg cccagggcca gccaggttct     1380

gctgggaagg gaagggaatg gggagaaggg agaagcaagc agtgtctgag cctca          1435


<210> 3012
<211> 5275
<212> DNA
<213> Homo sapiens

<400> 3012
aaacgtcggg aagaggcgcc aaaaggatgc tgggcctggc tccttgaagc ccgggttttc       60

ccttttgaga gccacaacca agaaataaaa atctagcaaa gagggggcca ctttctgcgg      120

cgagatacgc cctctcggcc gctcctccag ctcccaggcc ccctccctac tcgacggatg      180

gctgcagctc ctccaagtta ctgttttgtt gccttccctc cacgtgctaa ggatggtctg      240

gtggtatttg ggaaaaattc agcccggccc agagatgaag tgcaagaggt tgtgtatttc      300

tcggctgctg atcacgaacc ggagagcaag gttgagtgca cttacatttc aatcgaccaa      360

gttccaagga cctatgccat aatgataagc agacccgcct ggctctgggg agcagaaatg      420

ggagccaatg aacatggagt gtgcatagcc aatgaagcca tcaacaccag agagccagct      480

gccgagatag aagccttgct ggggatggat ctggtcaggc ttggtttaga aagaggggaa      540

acagctaaag aagccttaga tgtcattgtc tccttgttgg aagaacatgg acaaggtggg      600

aattactttg aagatgcaaa ctcctgccac agcttccaaa gtgcatatct gattgtggat      660

cgtgatgaag cctgggtgct cgagaccata gggaagtact gggctgccga gaaagtcaca      720

gagggagtga ggtgcatttg cagtcagctt tcgctcacca ctaagatgga tgcagagcat      780

ccggaactca ggagttacgc tcagagccaa ggttggtgga cgggagaggg cgagttcaat      840

ttttccgaag tcttttctcc agttgaggat catctagact gcggtgctgg caaagacagc      900

ttagaaaaac aagaagaaag catcacagtg cagactatga tgaacacctt acgggacaaa      960

gccagcggag tgtgcataga ctctgagttt ttcctcacca cagccagtgg agtgtctgtc     1020

ctgccgcaga atagaagctc tccgtgcatt cactacttca ctggaacccc tgatccttcc     1080

aggtccatat tcaagccttt catctttgtt gatgacgtaa aacttgtccc caaaacacag     1140

tctccctgtt ttggggatga cgaccctgcc aaaaaggagc ctcggttcca ggagaaacca     1200

gaccgccggc atgagctgta caaagcccac gagtgggcac gtgccatcat cgaaagtgac     1260

caggagcaag gtcgcaagct gaggagcacc atgctggagc tggagaagca aggcctggaa     1320

gccatggaag aaatcctgac cagctccgag ccactggacc ctgcggaagt gggggacctt     1380

ttctatgact gtgttgacac ggagattaag ttctttaagt gaagtaagcg ttccctttcc     1440

ccttcttatt taagacttcc caccttacta aattaccagc aaaacaaacc actctcctgt     1500

ttgagtaaaa tgagaaagtt aatatgtggc ctccttttct gaagccagat caaactgtta     1560

ccttgtgttc caccttgaat ctcacagcgt ccccttctgc aatgtaggtc tccttcctgt     1620

gcagtgtaac atgtatcccg ttgcctgttg ttcggttgtg tgactaattg tggattttaa     1680

gctgctatta ttgtatttca gtggcaatgg acacattagc cttttacaag aggactagag     1740

ttcatcaagc cttgaaaggc aggcttcaca gtgccgagtt ggcgggaaaa gcaaattctt     1800

ttgaagtctt agtctttccc tcagtagcgg tttctttcag gttaacaaga ggcatttgtg     1860

cacacacaca gggctcttgt gtgtgttgtc aaggggaccc tccgtggcct cccgtgagtg     1920

catgcctgta gtgcacagtg tctctacagg tgtcttctgg ggggcagaac caattggaag     1980

gaagaaaggg acccctctcc agtcctggct ccttcctaca tcctgggctc ctgaagaagc     2040

tgtcttccca ttttccatgc gctgtgctta tgtgtggtgg actgcagagc tgcttccact     2100

tacaggagag ctgataattt gttagctgga acctattcac ttccgagatt cagacatagc     2160

catgctggtg gccttctgaa tcactgcatg gatgtcccag gaggcagctc tccccacaca     2220

gcagcacagc catcacagga ttccttgtgt agaaatgatt cccagtctag ttaccaacag     2280

ctagtctagg agtaattgaa tggccctatg gcacagttcc acccacagag tagtgaatct     2340

ctcagccaag gagggaaaga aaaggaagaa ctcttgacta tttagattct agttaaatat     2400

ctggaatcct agcagtcact acattatctc agcagagaga ctttaattaa actgatttgt     2460

ttccaatgtc gggttcactt aaaggatttg acttaccacc agagcataga aaagcatgca     2520

aggaagacca gatgggctta gcattgggaa gacagagggc aaggaggtga tagatggata     2580

tagaagcatt tctctgcagg ataccagttc aggccccacc attcctgcca aggccattac     2640

atcccacaaa cccaaataca aagcagctga cttccctgga tcttcccccc actcctcaca     2700

cctcacatgt cccaggagct gccttcattc aggcgggtag ctgcactggg catggggtgg     2760

tggtgggagc ttaccgccac ctattcaagc tctcagctac tcctgaaacg ggcagagatg     2820

atgaacagaa gtgtatgtaa atacagcagc tagtgggaga gcaccagttg ggcctaatcc     2880

tgcctcatca ttcttggcag gaatctgcaa atggaaacat tgtgagtatc agcaatctgg     2940

gaagtgacag ggttaataac tccttcccag aagctgtatc atgagatttt gaggggaccg     3000

agccctgtta catggatgtg aacagtgagg atcagaggtt ttatcagaac acattctttt     3060

tttctaccaa ctctccagag cgtgagtata ggagtgccat gagcttttta gtcagcagtt     3120

ttgtaaactc tgtatataaa atcattaacc acacattgtg ggtgatggga agacgatttc     3180

agctgacaga gttaatggca accaataatg gtggcctgta gctgctaaga gcttcacgca     3240

ggtttggcct gggctttcac tgttggtgaa tttagagtgt ccttttaggt ggggcggcta     3300

ttctaaaagt gtctttctat cactgttaag ggggggggaa agtgaggttc gaggatgacg     3360

taggtaactc tcccctccca agtccatgtt ccaagtggct atgtaaagca agatgataca     3420

gaaagctgct ctaaaatctc actgagtgat ttcaccttcg cctactatga aatgtctcat     3480

cagacctgac atgtctgaga taaccaaggt gattcaggat ttgatcaaaa gaagtctagt     3540

aagaattaat tacacagaag cctcctttca tttctatggg ccaaacaaag gccatggata     3600

accctacccg ctttatgtca ttacccattg ggaaacacaa tggctacttc tgttagggta     3660

cattgacctt ggtcaagcat cttaaagaag gcaaccctaa ttgagagctg tcttggctaa     3720

tactctgcac cacaattgtg atgtcctagt cctaccacta gagggcatgg tacagcctgg     3780

caaaagttaa aaggggtgtg gcagctccca tcaggtctgg aggtggtcta taagcacagt     3840

tgacagttgt gcattgggat gggtggagaa agacgacaag agagcagaga atctgctgat     3900

gtggctgcgc ttacttttag tgactttatg tacttatatt aacagctgga aataggttgt     3960

tgggttttga gcaggctgtt atagtgagga atgttcattt ttaaatgttc ctaacagatt     4020

ttgcttttga aaaatgcttg ttacatgaat aatttgtgga ccagggattg cttttctgaa     4080

ggcagtatag ggaacatgaa tattcaagat gaaatacaaa aattatgttt aagggtcata     4140

gtgtataagt agcttcctag gaaacccttt gtgtatcttt tcagactggg gtgggggctg     4200

agcatgcttg tgcagaaaga agccatagcc agaaaggaca gaatctctcc cccactccct     4260

tgccccataa ccaaacataa gctagctagt cttgtctaat agatgggatt tactataggt     4320

gaagatagcc ctcatattca aggacagaag ctctggcagg agtaaattag caaagcagaa     4380

atagtaccct ttcattcttg gaggtgcttt gaaattttag gtagaatata atcgaaatta     4440

tggaggttcc ttagtgctca ataatataag acctggtgtt attagaacga gtctttctta     4500

taaactaaca gagcaggtat atgcctgtta gaccttagct gtggggttcc tttactattg     4560

ggtgaatcat taggtataaa aaataatcat caaccaggca aattactttg cttcctagct     4620

gatgtcatcc cacattggta caggtgttat tcagtactgg gtggttcagc agggaagccg     4680

ggtgggacca gtgtgtctgt catgaaacca ctaactgcat tcctgactga agagccatct     4740

gtcatttatt ggggaaggtc ttcagttgag ctctcagcct taggaaggaa gcacgtggag     4800

gagggacgga ggaggttccc ttgctgggca tgcttcgtag agggccagga gcagcaggtc     4860

atgtgcacat gccgttgcag cacaagctta tgcttcccgt agccgtggct tttcattctg     4920

cacagtccca ggtcccagct cccctcttat ggtttctgtc ataatgtgct ttatctgatt     4980

gactccaaac atcccgaaat gtcacctgca gatttctcgt gggaaccaat atgtacatgt     5040

ttgcaattat gctgtgagaa tttaaatgtg ttagatggaa aatgctattg gcagggaata     5100

ataataaaaa aaaaagaaaa tcattctgtt tcctgcagtg ggaactggcc atgtagtctt     5160

aacagtcttt tgtacaaata tctacaaagc agataatatc cctatccagt gcttgccctt     5220

ggaattgtct ctaaatgcat caagcataca ataaaaaaaa ctgaaattaa catcc          5275


<210> 3013
<211> 3037
<212> DNA
<213> Homo sapiens

<400> 3013
aggtgaaaaa ttagacgatt tcaagaattg gagctgaatc tgatgttaag taatggcaac       60

aggtgactta aaaagaagct tacggaacct agaacaggtg ctccgcttgc taaattatcc      120

tgaagaggtg gactgtgtag gtttgataaa gggagaccca gcagcatctt tgcccatcat      180

cagctattct tttacctcat actcacctta tgtaacagaa cttataatgg aatccaatgt      240

agagctcata gcaaaaaatg acttgcgctt tatagatgct gtctataagc ttcttcgtga      300

tcaatttaat tataaaccaa ttttgacaaa aaagcagttt atccaatgtg ggtttgcaga      360

atggaaaatc caaattgttt gtgatatttt gaattgtgtg atgaaaaagc acaaggaatt      420

aagcagtctt cagaagattc catcacaaca aagaaagaaa atcagttctg gtaagtcaga      480

acctcctttg ggcaatgaga aaatatctgc agaggctgtt ggcgttgata tcagtggcag      540

gtttatgacc tcaggaaaga agaaagctgt ggtgattcgt cacttgtata atgaagataa      600

tgttgacatt tctgaggata cattaagtcc aataacagat gttaatgaag cagttgatgt      660

gtctgactta aatgctactg aaataaagat gcctgaagta aaggttcctg aaatcaaggc      720

tgagcaacag gatgtaaatg ttaatcctga gattactgca ctacaaacta tgcttgctga      780

atgccaagaa aatcttaaga aactgacttc gatagagaaa aggttagact gtttggaaca      840

aaaaatgaaa ggaaaagtga tggtagatga aaacacctgg actaatcttc ttagtcgtgt      900

cactcttctt gaaacagaaa tgcttttgtc taaaaagaat gatgaattta tagagtttaa      960

tgaagttagt gaagactacg cttcttgtag tgacatggac cttctgaatc ctcacagaaa     1020

aagcgaagta gagaggccag caagtattcc tctgtcctct ggctatagta cagcatcatc     1080

agattcaact cccagagcct ctactgttaa ttactgtggt ttgaatgaga tttcagagaa     1140

ttttcctgca tggagtgcta catcctcttg ttccagtctc agctggctgc tccgtgggca     1200

tacttcatac ctttcatcac agagctttgc ttggcctctc tcctgtgtgt aatctctgtt     1260

tcttggatcc tgtgcttacc ttttcctgct gtactctgat gtttcagtga agctcatcca     1320

cgaagtccag aattctgcct ggaaaccagc ttcctcctca gctccagctc ttttaatggg     1380

catatcaaaa ctgatgactt tttccttcct gctacatggg taacacttag ttgtttgtct     1440

aatttctatt ttccagaaat ttctcaaaat gtctgctgat agcccctcac tcatattttt     1500

catgtgggtt tatagctttc atatttcttt attattgtaa atgggggctg tggaaggtga     1560

gaaaacacat gctttcttaa aacagaagct ctctccttca ttaatttaaa tatttttatc     1620

ggctctagaa aatgcataag gttagtacaa gatcagtaga gagaaagtca aagattacag     1680

aagtgctgaa gcagaccatt cttcctttct tcccaatgtc tattaagatc acacataggt     1740

aaactgttac aaatccagaa tggtgaaaga gtccaacaat ggctgaggga agtagaggtt     1800

aagatatagc tcaacagtga aagtagcagg gaaagagctg ggcaaggcca agaccatctt     1860

ttgtaccgtt ggtacagtag gctaaaggta cggtgttcca tattaaatac agcaatatga     1920

agaaaaataa attaagtccc ttatacctaa gacctctatt tctctgttga ttacatacac     1980

agtggcaatg gaaagaaggg aaaataatgg ggatagcatt tgctcattct ctgaccatgc     2040

aacactggca gcattctata cttattctat taactgcatc aaccacatct tataaaacac     2100

atttccatag gccatatgta ataggccttg gctttattca ttgcatttat tggctcctta     2160

aattgacaac atataattgt tttcatataa ttttcatcaa ataaaattca ctttaatttg     2220

tatgaacata tttaaagtgg aaagtatctt cccaaatggt ccatatctta aagtgtcaga     2280

tattttatgg gcttcacatc tgaactgcca gagatctcag gcatagcatg cattaatcac     2340

aaccacttac tgacctggtt cagatactta ctcaatacat ggggctagac acagagtgtg     2400

ccttaggcta aagaaaaaat tattcaagtt gagcatatcc ataaactctg gctcaagcag     2460

tgtattttgg gggtaataaa cacaagtttg ttcctagttg gagggatatg atgcttaggt     2520

ttgaacctgt taaccttcct gggtttgagg gctagaaaac gtggagacat tcctttctaa     2580

ctaacacatt ttctaataga aacaatccac caggatgttg agcccacatt ttaagagttc     2640

ttcggaattt actgaaaatg gaaaactgat tacattgggc acataggaca tttatattta     2700

tagaaacatt ttagataaga caagaatttt aaaagccaga aatcactttt agtgggcatt     2760

ttcagaaaaa tgttgtcaac tttttgtaat ttttaatagg cataaaaaag attgttatat     2820

tgatattgac agaaattagg tggttaatta gagagcgtaa aaggatgaat tgctctaaca     2880

ttggtttaga atttttcttt atatgattca attttgtggt ctggcaaagg cccaatagtc     2940

atttatctag tatgcatacc tttccacagc tggattttca aatatgatga taaagttcat     3000

atgacagacc tattctgaaa ataaatatgt cagcagg                              3037


<210> 3014
<211> 2403
<212> DNA
<213> Homo sapiens

<400> 3014
ctgcgcaggc gccgagcggc cgaggcgccg cggtcggctc tgggactcgt ctggcgtccc       60

tcagaggcag aagaggcctg gaccttggcg cacacagacc caggaacaga tgagcaggga      120

tgtctgcatc cacacctggc cgtgcaccta ctacctggag cccaagaggc gatgggttac      180

tggacagctg tccttaacat cgctgtcgct caggttcatg actgacagca ctggagagat      240

tctggtcagc ttccccctct ccagcatagt tgagatcaag aaggaggctt cacattttat      300

cttcagctcc atcaccatcc tggagaaggg ccatgccaag cactggttca gctccctgcg      360

gccaagtcga aatgtggtct tcagcatcat cgagcatttc tggagggagc tgctgctgtc      420

tcagcctgga gccgtggcag acgcatctgt cccaaggacc cggggcgagg agctgacggg      480

actcatggct ggatcccaga aacgcctgga ggacacggcg agggtcctgc accaccaggg      540

ccagcagctg gacagcgtca tgagaggcct ggacaagatg gagtcagacc tggaggtggc      600

ggacagattg ctgacagaac tggaatctcc tgcttggtgg ccctttagct ccaagctttg      660

gaagacacca ccggaaacaa agcccaggga agatgtctcc atgaccagtt gtgaaccctt      720

tgggaaagaa gggatactga taaaaattcc tgctgttatt tcccacagaa cagagtctca      780

cgttaaacca gggaggctca ccgtccttgt gtctgggttg gaaatacatg actccagttc      840

tttgctcatg cacaggtttg aaagagaaga cgtggacgac atcaaggtcc actcacctta      900

cgaaattagc atccgccagc ggtttattgg aaagccagac atggcctatc gtttgatatc      960

tgccaagatg ccagaggtta tccccatttt agaagtgcag ttcagcaaga agatggagct     1020

gttagaagat gcattggtgc tcagaagcgc aagaacctct tcccccgcag agaagagctg     1080

ctcagtctgg catgcagcat ctgggctgat gggccgtacc ctgcaccgtg agccacccgc     1140

aggagaccag gagggcacag cactgcacct gcagacaagc ctgccagccc tttctgaggc     1200

agatacccag gaactaaccc agggcttccg gcctatgtcg ctgtcaaccc agacagtgtt     1260

ggtgatgctt tgctccgagt ctgcaggagc tttgtggaga cagagacttt cctagcaggg     1320

cagcaagcgg aagcttttct tccagaacag cctttgctca gggcatgagg gagccggcca     1380

ggcccacagc gcccagggca tcctcctcac ggatgtgttg gaggaaagtg gctttggtgc     1440

tatcctgggg gaccatggcc ataagctggc agtgtcagcc acgcatcagt tgcgtttctt     1500

tgttcaggtt gtgcctcttg ctgcctgcct gagtcaccca gggctgctcc ccttcctggc     1560

tctgacgccc tcagcgggtc ccacaagccg ctcaggacca cagagtctgg ccatgggtct     1620

ggccaggcat ccactgatgc tctaagctgc agcttctctt aggaacactt ctatcaggtc     1680

tggctcgcag gcatgcccca gggccagcct ggattgtact gtccttcaag cactccttgc     1740

tctatttctt tgaagtttat aaaagtttgt ttcccccaaa acccaaagca cttttaatca     1800

ggtagtttct gtggaggtcg aactggctgg aaggaaggct ggttcctgga tttctttact     1860

catgtagcag ggactcaagg aagtctgatt tgcgcctcgc ctctgactca gagcccatga     1920

aggttcctgt gtgaggccac tggctgcctc ggagctgaca gcatcctgca caatggctag     1980

atggcttgtc accccaggcc gcagaggaac aactgtttct agggtttggc cagacttcac     2040

attctccatt ctttccatcc ctgttatgtg gaatgcacac gatgccatgt aattacttca     2100

gtcccttctc aaaggaaaaa gaatctggac ctgcactcca ggacactagc agtttgaagg     2160

ttcgctcagg aatgttcttt gtctgcagac ctagcagctg tacagatcgc tcttgtgttt     2220

ttgcactatt aattaacttc aagtgcaatt ttggcaggca ggccaagggt ctcaacaggc     2280

tatttggaat gagttctctt ttaaggcctt caacgtagtg agacattttc aaatcaaaaa     2340

gtacagcagg agccagcctt tattttgtct gtgtacacaa taaaatattc cgcttctata     2400

ggc                                                                   2403


<210> 3015
<211> 2020
<212> DNA
<213> Homo sapiens

<400> 3015
ctacacacgt gtgtgtgcgc gtgtgtataa aacacagtgc actaatactc agcctttaaa       60

aaaaatgcca cttgcaacaa cgtagatgga gctggacgat atcatgctaa aattatgcaa      120

agtgaaacaa gcacaaaaaa gaacgagaca cgggcgtggg gcacgaggtg ctcactgcgc      180

aagcgcccac tccaccgcgt ggtttccagc tggaggctgg gagcgttcgt ggcttcctct      240

tttcttgctg acccttcgga gctctgggaa gtggctgcac cttggcggct ccccagagcg      300

cgcggtgcta atcgtgggtc gtcagcctgg gtggctgggc ccggcttagg gcagggtttg      360

gcatttccaa tggtaggggg ctcggaccgt ccctccgcgg gaccctcccg ttgggacaag      420

gccgatcgcc tgggcggttg gagccgctat cctggcgcga gacggtggac aagtcctata      480

ttcaagagaa gataactttg aacagtttcg aaggatctaa aacgtatgtg tctgcagaca      540

tcaatgagga tgaagaatta gtagaagaga ttaatagatc aaaaacgttt gctggctttg      600

caggtggtgg gcctgcctgg gcatcggcgc gttggaggag acgccctggg gggccttagc      660

tgccctgaag cggtagacag gtggcaacgt gggggctcag gagttgacaa acacaagaaa      720

gcagcgccga attgcaggtt tatccgcagc ttttattttg aagacagtgc cacgaaacct      780

gcaaatcctg gtgtcccaaa tagtcaatac caagttgaaa accatctggg agaggaaaag      840

cgttgtgctt tagacaggcc gtctgagact cgtgcagacc ggcttttgag agctggacag      900

gtggtggata gatcagactc catacacccg aggagccccg ccatgcatag tgaagaagct      960

agataacagt cgtttcacaa ctggccagcc tctgcccact tgaccccgag agagctggcc     1020

agtgctgggc tgtactacac aggcactgat gaccaagtgc agtgcttctg ttgtggcgga     1080

aaactgaaaa actgggaacc tggtgatcgt gcctggtcag aacacaggag acattttcct     1140

aattgcttct ttattttggg ccacaacgtt aatattcgag gtgaatctga tgttgcgagt     1200

tctgatagga atttctcaaa ttcaacaagt tctccaagga atccatccat gacgggttat     1260

gaagcccggc tcattacttt tgggacatgg atgtactccg ttaacaaaga gcagcttgca     1320

agagctggat tttatgctat aggtcaagag gataaagtac agtgctttca ctgtggagga     1380

gggctagcca actggaagcc caaggaagat ccttgggaac agcatgctaa atggtatcca     1440

ggttgcaaat atctgctaga agagaaggga catgaatata taaacaacat tcatttaacc     1500

cgttcacttg agggagctct ggtacaaact accaagaaaa caccatcact aactaaaaga     1560

atcagtgata ccatcttccc taatcctatg ctacaagaag ctatacgaat gggatttgat     1620

ttcaaggacg ttaagaaaat aatggaggaa agaattcaaa catctgggag caactataaa     1680

acgcttgagg ttcttgttgc agatctagtg agcgctcaga aagacactac agaaaatgaa     1740

ttgaatcaga cttcattgca gagagaaatc agccctgaag agccgctaag gcgtctgcaa     1800

gaggagaagc tttgtaaaat ctgcatggac agacatatcg ctgttgtttt tattccttgt     1860

ggacatctgg tcacttgtaa acaatgtgct gaagcagttg acagatgtcc catgtgcagc     1920

gcggttattg atttcaagca aagagttttt atgtcttaat gtaactctac agtgggtgtg     1980

ctatgttctt attaccctga ttaaatgtgt gatgtgactc                           2020


<210> 3016
<211> 876
<212> DNA
<213> Homo sapiens

<400> 3016
ggcagcgcgg gcctcggggt cctggggcga gacggtgagc gtgggggctg ggccggcgcc       60

aggggcgccg tttccttccc ccacgcagct ccgcgcgccc gggcctccac atcgtcgcta      120

acggagcgtt gcggcgccgg cgacccctgg cgagcccggg gcgggacagt ggccaggccg      180

gcctgggccc agcgcgtggc ctccgccgtt tcgggctgtg ctgggtggaa gattaggctc      240

cccgggcacg ccgtccccgc cgagaggcct cagcttcgtg gcagcgccct cgtccttcca      300

gcccgctcga gggtggccgc cagggcgcga tgaaggaatg tgagaaagtg cttagcgctc      360

cagccgctcc gagggaagcc aggtgggagg agatcccgaa acgctaaggt tttgacagcg      420

ttacagtgaa ttctccggct gtagagattg gaggaagtcg ggagaaattc gtctctaagt      480

tgtaagcttg ttctaaagac gaaggggaac tccctagtgc tacaggctgt ttcaggaagc      540

caattaattt tgtacacata atacttaatt accttctaat aattggagca gaagatgaac      600

ccaactaatc ctttcagtgg gcagcagcct agtgcttttt cggcgtcttc tagtaatgta      660

ggaacacttc catctaagcc gccatttcga tttggtcaac cttctctttt tggacaaaac      720

agtaccttat ctgggaagag ctcgggattt tcacaggtat ccagctttcc agcgtcttct      780

ggagtaagtc attcctcttc agtgcaaaca ttagggttca cccaaacctc aagtgttgga      840

cccttttctg gacttgagca cacttccacc tttgtg                                876


<210> 3017
<211> 816
<212> DNA
<213> Homo sapiens

<400> 3017
acctactcta gggagggggc tgtgctggtt ctgcctgggc agccccacgc tgaggtcgcc       60

tgcgaggccg ctggccaggc ctgagcctct gccaccatgg ccattgtgca gactctgcca      120

gtgccactgg agcctgctcc tgaagctgcc actgccccac aagctccagt catgggtagt      180

gtgagcagcc ttatctcagg ccggccctgt cccggggggc cagctcctcc ccgccaccac      240

ggccctcctg ggcccacctt cttccgccag caggatggcc tgctacgggg tggctatgag      300

gcacaggagc cgctgtgccc agctgtgccc cctaggaagg ctgtccctgt caccagcttc      360

acctacatca atgaggactt ccggacagag tcacccccca gcccaagcag tgatgttgag      420

gatgcccgag agcagcgggc acacaatgcc cacctccgcg gcccaccacc aaagctcatc      480

cctgtctctg gaaagctgga gaagaacatg gagaagatcc tgatccgccc aacagccttc      540

aagccagtgc tgcccaaacc tcgaggggct ccgtccctgc ctagcttcat gggtcctcgg      600

gccaccgggc tgtctgggag ccagggcagc ctgacgcagc tgtttggggg ccctgcctcc      660

tcctcctcct cttcctcctc ctcttcagct gctgacaaac ccctggcatt tagtggctgg      720

gccagtggct gcccatcagg gacgctatcc gactctggcc gaaactcact gtccagcctg      780

cccacctaca gcaccggagg tgccgagcca accacc                                816


<210> 3018
<211> 1846
<212> DNA
<213> Homo sapiens

<400> 3018
ggccttcctc tcccgcttcc gcctggcgta ggagctgagg catggccttg ttctccagct       60

gagaggacga tcgtccttat aggagaggcc gagtctccga gggcaatttc agaggtctgg      120

tgcgagggaa gcagagactt tcaaggaaca aggaaatgca tactatgcca agaaagatta      180

caatgaagct tataattatt atacaaaagc catagatatg tgtcctaaaa atgctagcta      240

ttatggtaat cgagcagcca ccttgatgat gcttggaagg ttccgggaag ctcttggaga      300

tgcacaacag tcagtgaggt tggatgacag ttttgtccgg ggacatctac gagagggcaa      360

gtgccacctc tctctgggga atgccatggc agcatgtcgc agcttccaga gagccctaga      420

actggatcat aaaaatgctc aggcacaaca agagttcaag aatgctaatg cagtcatgga      480

atatgagaaa atagcagaaa cagattttga gaagcgagat tttcggaagg ttgttttctg      540

catggaccgt gccctagaat ttgcccctgc ctgccatcgc ttcaaaatcc tcaaggcaga      600

atgtttagca atgctgggtc gttatccaga agcacagtct gtggctagtg acattctacg      660

aatggattcc accaatgcag atgctctgta tgtacgaggt ctttgccttt attacgaaga      720

ttgtattgag aaggcagttc agtttttcgt acaggctctc aggatggctc ctgaccacga      780

gaaggcctgc attgcctgca gaaatgccaa agcactcaaa gcaaagaaag aagatgggaa      840

taaagcattt aaggaaggaa attacaaact agcatatgaa ctgtacacag aagccctggg      900

gatagacccc aacaatataa aaacaaatgc taaactctac tgtaatcggg gtacggttaa      960

ttccaagctt aggaaactag atgatgcaat agaagactgc acaaatgcag tgaagcttga     1020

tgacacttac ataaaagcct acttgagaag agctcagtgt tacatggaca cagaacagta     1080

tgaagaagca gtacgagact atgaaaaagt ataccagaca gagaaaacaa aagaacacaa     1140

acagctccta aaaaatgcgc agctggaact gaagaagagt aagaggaaag attactacaa     1200

gattctagga gtggacaaga atgcctctga ggacgagatc aagaaagctt atcggaaacg     1260

ggccttgatg caccatccag atcggcatag tggagccagt gctgaggttc agaaggagga     1320

ggagaagaag ttcaaggaag ttggagaggc ctttactatc ctctctgatc ccaagaaaaa     1380

gactcgctat gacagtggac aggacctaga tgaggagggc atgaatatgg gtgattttga     1440

tccaaacaat atcttcaagg cattctttgg cggtcctggc ggcttcagct ttgaagcatc     1500

tggtccaggg aatttctttt ttcaatttgg ctaatgaagg gcaaccaccc agaacccaga     1560

aaatgcagat tcactcagtt taatcttgaa tgtggaaaca gttcacctcc tcccttcatc     1620

acgtctccgt gtgcttagag cagtttcgtt ttctcagttg gatgccctgt gtctctgtga     1680

gtggggtgga gcaaagggaa ccaatgccga agaccgaggg caggggaggg aggcgggggt     1740

ggacagggag gcagcttgtg aatttttgtt ttactgttta actttattaa aaaagaaaaa     1800

aaaaagagaa taaaatgttt tgacccttcc tggccctttg ctctgg                    1846


<210> 3019
<211> 1732
<212> DNA
<213> Homo sapiens

<400> 3019
cctctaggac cggaaaattc tgggaaggct cgaggccgcg gtccccgggg tccgcatagt       60

cccgatgaaa aacagacccg ggaaagctgg tgggagtcag gagccccggc gatgaggatt      120

gcgatgaagg aagcaggctc ggagcgccgc cagcgcatgc gtattgggga tctgaggcca      180

gcgtcttgcg ccgccattgc ggggaggctg tcctcagagc aggtctggcg cgccggtggc      240

tggaccggcc ccaggagccc agtcaccggg cgtcattggc tcaggctgcg gggccctcgg      300

caccttctcc ctcccgggtc caccgcggcg gcggcggcgg cggcggcggc ggcggcggcg      360

gcgtcagggg gcggagcctg ccgaagcgcc ctttgtctgc ggaggtcaac atacctggcc      420

taaggaggca ggattgagtg actctcactc accactggtg ttgctctttg aaagtggcgc      480

ttggcaccag catgaactcc ccatcctcag caatcccatc aggtgttttg ggtcttcaac      540

ctaaaattct atcttacaag atccttgcca ggatgcagat ttgaatacta tagtgaagtc      600

tgtacatgaa gaaatgatgc ttttagggag gaaaaaaaaa ggtaataaca accttcaaga      660

gccccttcat ctcaactcgg cataaacaag gcaagattct gagagtggcc gcccctggaa      720

gcagaaatta ttcttgtggc tatccattgg ctcctgaggc tctaatcaga gatggggcac      780

ctttagtacc aggggagtga ctgttgccca taaggtactg gacatcaact ttcaagagca      840

gccccagctc cttaagctgc tggtcctggt gcatctgctg actttcatgt agaagatagc      900

agagctttgg cgacattaca acataagaac tgcagagagg tgtaatccca gtggaagact      960

gaatcgagag actcaaaaag gaaggagggg aacatggagg aggaagaaat gaatgatggc     1020

tcacagatgg tgagatctca ggaatcactg acgtttcagg atgtggccgt ggacttcacc     1080

agagaggagt gggaccagct gtaccctgcc caaaagaacc tctatcgaga cgtgatgctg     1140

gagaactaca ggaatctagt tgcactgggg tatcagcttt gtaagccaga ggtaatcgcg     1200

cagttggagc tagaggaaga atgggtgata gaaagagaca gcctgctgga tactcatcca     1260

ggtgaccaaa gccacgtaat gtccgtagtt cgctcatccg tccatgccag atggattgtg     1320

gggaaggtga ttgggacaaa aatgcaaaag actgctaaag tgagagtgac caggcttgtt     1380

ctggatccct atttattaaa gtattttaat aagcggaaaa cctactttgc tcacgatgcc     1440

cttcagcagt gcacagttgg ggatattgtg cttctcagag ctttacctgt tccacgagca     1500

aagcatgtga aacatgaact ggctgagatc gttttcaaag ttggaaaagt catagatcca     1560

gtgacaggaa agccctgtgc tggaactacc tacctggaga gtccgttgag ttcggaaacc     1620

acccagctaa gcaaaaatct ggaagaactc aatatctctt cagcacagtg aagcgggagt     1680

ggaagaagga tctaaaggga aaaactgaca tgtttatgtt atggaaaaag aa             1732


<210> 3020
<211> 926
<212> DNA
<213> Homo sapiens

<400> 3020
tcggcttccg aatggaagag gtctgtgaga agttaacctg gtgataccga tccgaagagc       60

ctatcaagtg aagccccctg aaatacggag aataagaatc ttagaggtaa atccgaggac      120

aagcaggttg ttcagcagaa gtcttggagt gcattttcag tggttaaggt gaaaaaatga      180

ctactaaaaa tttagaaacc aaagtcaccg ttacttcatc cccaatccga ggagcaggag      240

atggaatgga aactgaggaa ccacctaaat ctgttgaagt tacctccgga gtccaatcta      300

gaaagcatca tagtcttcag agtccatgga agaaagcagt tccatcagag agcccaggag      360

ttcttcagct agggaaaatg ctcactgaaa aagcaatgga agttaaagct gtaagaatat      420

tagttcccaa agctgctata actcatgata tccccaacaa aaatacaaag gttaagtctc      480

tgggacatca taaaggagaa ttccttggtc agtcagaggg agttatagaa cctaataagg      540

aactctcaga ggtaaagaat gtattggaaa agctcaagaa ttctgaaaga aggttactac      600

aggacaaaga aggtctttca aaccagctcc gtgtacagac agaggtaaat cgtgagttaa      660

aaaagttact ggtggcttct gttggggatg atcttcagta tcactttgaa cgtctagccc      720

gtgagaaaaa tcagcttatt ttagaaaatg aagccctagg tcgaaacaca gctcagcttt      780

ctgaacagtt agaacgtatg tcaatacagt gtgatgtatg gcgaagtaaa ttccttgcaa      840

gcagggtaat ggcagatgag ttaaccaact caagagcagc tttacagcgt caaaaccgtg      900

atgcacacgg ggctatacaa gatctc                                           926


<210> 3021
<211> 559
<212> DNA
<213> Homo sapiens

<400> 3021
gtgtgtacgg gtgtgtgtgt gtgtgtacgc cgacacgtcg gtgcggaccg acgcgggggt       60

gtcaggagct gggacggccg ggggcagaac tgcaaggtgt ggaatatttc tggcttctag      120

tccaatgcca agtgtgtgac ctgtggctac atgattccct gaaagataag aacaatgtta      180

tgttggggat attggtctct gggccaacct ggtatcagca ccaacctgca gggaattgtg      240

gctgagcccc aggtgtgtgg gttcatatct gacagaagtg tcaaggaagt ggcctgtggg      300

ggaaaccact ctgtgttcct gctggaagat ggggaagttt acacatgtgg tttgaacacc      360

aaggggcaac tgggccatga gagggaagga aacaagccag aacaaattgg agctctggca      420

gatcagcata tcattcatgt ggcatgtggc gagtcccaca gtctggccct cagtgaccga      480

ggccagctgt tttcttgggg tgcagggagt gatggtcagc taggactcat gactactgag      540

gattctgtgg cagtgccca                                                   559


<210> 3022
<211> 1754
<212> DNA
<213> Homo sapiens

<400> 3022
gggaaaacca actgtaacgt gccacccaaa tgtaagtttt actcatattt tgatgttagg       60

atggatagct tggaaaaagt tggagggtac ggcctttact atgaggcatc tatgaaggat      120

caggaatgga tgtagacaag gaactaggaa tggaaagtgt taaagctgga gcctctggaa      180

aaccagaaat gaggctgggc actcaggaag aaacaagtga aggtgatgct aatgaaagct      240

cattactagt cctgtccagc aacgtgcctc tcctggccct agagttcttg gaaatagccc      300

aggccaaaga gaaggccttt ctccccatgg tcagccacac gttccacatg cgcacagagg      360

agtctgatgc ctcacaggag ggcgatgacc tacccaagtc ctcagcaaac accagccatc      420

ccaagcagga tgacagcccc aagtcctcag aagaaaccat ccagcccaag gagggtgaca      480

tccccaaggc cccagaagaa accatccaat ccaagaagga ggacctcccc aagtcctcag      540

aaaaagccat ccagcccaaa gagagtaaca tccccaagtc ctcagcaaaa cccatccagc      600

ccaagctggg caatattccc aaggcctcag tgaagcccag ccagcccaag gagggtgaca      660

tccccaaggc cccagaagaa accatccaat ccaagaagga ggacctcccc aagtcctcag      720

aagaagccat ccagcccaaa gagggtgaca tccccaagtc ctcagcaaaa cccatccagc      780

ccaagctggg caatattgcc aagacctcag tgaagcccag ccagcccaag gagagtgata      840

tccccaagtc cccagaagaa accatccagc ccaaggaggg tgacatcccc aagtcctcag      900

caaagcccat ccagcccaag ctgggcaata ttcccaaggc ctcagtgaag cccagccagc      960

ccaaggaggg tgacatctcc aagtccccag aagaagccat ccagcccaag gagggtgacc     1020

tccccaagtc cctagaggaa gccatccagc ccaaggaggg tgacatcccc aagtccctag     1080

aggaagccat ccagcctaag gagggtgaca tccccaagtc cccagaagaa accatccagc     1140

ccaagaaggg tgacatcccc aagtccccag aagaagccat ccagcccaag gagggtgaca     1200

ttcccaagtc tccaaaacaa gccatccagc ccaaggaggg tgacattccc aagtccctag     1260

aggaagccat cccacccaag gagattgaca tccccaagtc cccagaagaa accatccagc     1320

ccaaggagga tgacagcccc aagtccctag aagaagccac cccatccaag gagggtgaca     1380

tcctaaagcc tgaagaagaa acaatggagt tcccggaggg ggacaaggtg aaagtgatcc     1440

tgagcaagga ggactttgag gcatcactga aggaggccgg ggagaggctg gtggctgtgg     1500

acttctcggc cacgtggtgt gggccctgca ggaccatcag accattcttc catgccctgt     1560

ctgtgaagca tgaggatgtg gtgttcctgg aggtggacgc tgacaactgt gaggaggtgg     1620

tgagagagtg cgccatcatg tgtgtcccaa cctttcagtt ttataaaaaa gaagaaaagg     1680

tggatgaact ttgcggcgcc cttaaggaaa aacttgaagc agtcattgca gaattaaagt     1740

aaacatgtat tctg                                                       1754


<210> 3023
<211> 499
<212> DNA
<213> Homo sapiens

<400> 3023
agaccgcggt gacgtctcca ccgcgccaaa ctcactgaaa atcaaaccgc taccattagg       60

agccctccac gcttaacata tccgttcttt ctcgtttgaa agtaaccagg ctgctcctcc      120

ccatttttcg ccttcttctc gcggaggctg agagactaac cttacacaac atggcggcct      180

ggtgtgtctg gtgtcctaga gcggacgaaa gcaggtgact ctctagtcaa cttccgactt      240

ggactccgaa gatcggcgtc tgcgctcggt ttgagggctc ggcgcggggt ttcctgttcc      300

tccttctgcg cggctgcagc tcgggacttc ggcctgaccc agcccccatg gcttcagaag      360

agctacagaa agatctagaa gaggtaaagg tgttgctgga aaaggctact aggaaaagag      420

tacgtgatgc ccttacagct gaaaaatcca agattgagac agaaatcaag aacaagatgc      480

aacagaaatc acagaagaa                                                   499


<210> 3024
<211> 4068
<212> DNA
<213> Homo sapiens

<400> 3024
tcacggtggt ggcgtggaga cgtgggggcg cttccggcag cggcggcggt ggtgaaggcc       60

gatgctgtgg gggtgggcgt ggagagaatt cttctgtggg tcctctggtg ttgagtggtc      120

ggcttggtgt ggtgtgcgga ggagctccag gcccgtcggc gcggaggctt tcaggtatag      180

gctgggtcac tagtcttaaa acatttcttc ttgagaatgt ctaaaagact gtggaatctg      240

ttagatctta tatactttta agttggcacc tgaaactttt catcctagat ttacatagtg      300

gtcttgctgt gttgcccagc ctggtcttga attcctggac tcaagtgatg ctcctgcctt      360

ggcttcccaa actcctggaa ttacaactca atgaatgacg gtttttgttg ctccacatcc      420

tcgtcagcat ttggtgttgt cagtgttttg gatttcggcc attctgacag tggtctcacg      480

tgtgaaacat ggctacagat tggctgggaa gtattgtgtc catcaattgt ggagatagct      540

tgggtgtcta tcagggaaga gtgtcagctg tggatcaggt cagccagacc atttctctca      600

cccggccttt ccataatgga gtgaagtgtc ttgttccaga agtcaccttc agggcaggtg      660

acattacgga gttaaaaatt ctggagatac caggacctgg agacaaccaa cattttggag      720

accttcatca aacagaatta ggcccctctg gtgctggctg ccaagtgggc atcaatcaga      780

atggcacagg caagtttgtc aagaagccag cctcttccag cagtgcccct cagaatatcc      840

ctaagaggac agatgtgaag agccaggatg ttgccgtttc cccgcagcag caacagtgct      900

caaagagcta tgtcgacagg cacatggaat ccttgagtca gtccaaaagt ttccgtcgtc      960

ggcacaactc ctggtcatct agtagcaggc acccaaatca ggcaactccc aagaaaagtg     1020

gtttaaagaa tggccagatg aagaataaag atgacgagtg cttcggggat gatattgagg     1080

agatcccaga cacagatttt gattttgaag ggaacctggc tctttttgac aaggcagctg     1140

tgtttgagga gattgatacc tatgaaagga gaagtggtac ccgttcccgg ggcatcccaa     1200

atgaaaggcc cactcggtac cgccatgatg agaacatctt ggagtccgag cccattgtct     1260

atcgacggat catagtgccc cacaacgtga gcaaggagtt ctgcacggac tctggcctgg     1320

ttgtcccaag tatttcctat gagctgcata aaaagctgtt gtccgtggct gagaagcatg     1380

ggctgaccct tgagcggaga ctggagatga caggtgtgtg tgccagtcag atggcactga     1440

ccctcctcgg aggacctaac aggttgaatc ccaaaaatgt tcaccagagg cctacagtgg     1500

ctctactgtg tggacctcat gtgaaggggg ctcagggtat cagctgtgga aggcacctag     1560

ccaaccatga tgtccaggtc atccttttcc tgcccaattt tgtcaagatg ttggaatcta     1620

tcaccaatga gctgtcgctc ttcagcaaga cccaaggcca acaagtgtct agcctcaaag     1680

atctgcccac tagccctgtg gacctggtca tcaactgcct ggattgccct gagaacgtct     1740

tcctgcgcga tcaaccctgg tacaaggcag ctgtggcctg ggccaaccag aaccgggcac     1800

cagtactcag catagaccct cctgtgcatg aagtcgaaca gggcattgat gccaaatggt     1860

cactggcact gggcctgcct ctgccactgg gggagcacgc aggccgtatc tatttgtgcg     1920

acattggcat tccccagcag gtcttccagg aggtgggcat caactaccac tcgccctttg     1980

gctgcaagtt tgttatccca ctgcactctg cttagagggt tcctgcgcag gcaggactct     2040

gctgtcccct gctgctcctg ataacaaacg ccttaaggat atgaagcttc atggaccttg     2100

ttaaagtttt ttctcttttg ggtttgtttc ttctgtgaga gaacagaact tacttaaaac     2160

tgacctgtca cttgctctta gccagggaag tctttcccac tgggttccgg gctgggtggc     2220

aggctgagcg tgcagcaact ccaggcatct ctaccctcag ccccctgcac ggccaggtgg     2280

gcctttgttt acagccgtag gcagctctca agactgtgtt tcaggtttac agccactggg     2340

cctgggcaca cacattgaag agtgggccag gtcctgtctg ggggcctgta cctgctctat     2400

ttcagagctt gtggctttgt gtctcccctg ctttccccac gcagacagcc cttcctctgt     2460

agaaccagct gcacggcagc tgtccaccag agggcagacc tgcactctcc attcatgtcc     2520

agggctgtga cagaccaggc cttcccctag ccccacaagt tgatttgggg ggttttgacc     2580

cttactcctg agctgatcca agttttatgc tgatttttcc aaggatctct ccctcctttt     2640

ccctccatca ctcagaggta gggaaggggg cggcattagg atggtgttac tgtattggga     2700

ttttatgttg ttctgtcgtc ttcagcacag gtagtataag gttatattac tgtagaacca     2760

cagtgcccat cttgccagca gtgcccgccc ccaccctcaa agctgagcag gttgagcctt     2820

tgcctagtct ggggccagac ccctcagatg gggatatccc tgggggagcc tggtgctgaa     2880

ccagaagagg cttcctggtg cttctgtcct aggccaccac tcctccagcc ctttgcccgc     2940

acatacatgc cccacctact ctttcatccc ctctgccctt cccctgaaac ggtcctttgc     3000

agctgtcatc ccagagcagg cagatgggct cccgtgcttg agctccaccc cagctcttac     3060

atcatctggg ctttgaacct tttacatttg tccagtctag atgagtaggc ttggggccag     3120

caccctgtct caaagatggc aaaatgaggc tagttctgga tgagctagct ggtgtgggtt     3180

ccaaccatag gaacacactg atgctcaaat cctaaggtgc caagctctag gccctggagg     3240

ctggtagaac aggatctatg cctggaatcc tggcagggat tcctgtcaag gacttgtgtt     3300

taagcctgct tcagggcttc aggctgcttc tgctctgtgt ctgcccaggc tggctgagcg     3360

ggtggatggg tggacagaag ggctcaccaa ggattgtgga catagggtag gccctggtac     3420

cacgggtttc aggctgttat cacttccctt gtaggaacat agccagaagc agatgagcca     3480

gggtagaggg ctggcccctc ctctcatctt cccttcagtc ttaaattgtc tccagcgatg     3540

ggaagaggcc agggactgta acccttgtgc tgtgtattct ctgagcctct gctcactctc     3600

agggccaagc agctcccaag ccggggccct ctcttggcca aaatctgagg agcagtctag     3660

gttacaggct ttttggtagg taggttctgg ctgcctgtta atgcagttag gccccctgat     3720

taggtacagt gagaaacaag ctagaacaac cctggcccag aagactgtcc actccagcaa     3780

gatccaggga tgatagcctt gcagggccac tgggagtttg tgcccaagct tctccctctt     3840

ctctccccag ggggcactgg gactggtccc tgccctcatc cttagcctgg gccttcccca     3900

gaggtattaa agagaagtat gattcctctg tcttcagttc ttttcagggg catcctgccc     3960

atagtaccca gttcccaagg ggcccccagt cacgtggtga agcctagcac tcatgcagct     4020

cttagggaac caaaaaccag cactgaaata aagctgaatg actgactg                  4068


<210> 3025
<211> 4112
<212> DNA
<213> Homo sapiens

<400> 3025
aaacattaaa gcctaacctg aggtaatccc tcaccggcag tgaagctcct ctgctaggca       60

ctgtcgtccc gtacactgcc caagctctgg gggtgtcaca ctaaactgtg gtgatgtcac      120

actagctggg atgacatttt acagttggat cccgtaccac cgccaggcac ctttaaatca      180

ccgcagagtc tgcagtgcgg agggggcggg aagtccaggc cccgcactcg atccacgctg      240

gctccctacg gaggcccacc tactcgaggc ccaccgactc ctactgcaat cagtactatg      300

cgatcgtcct agagagtcca ttcagctgca cttccgcctc agtatggcat cacagctgca      360

agtgttttcg cccccatcag tgtcgtcgag tgccttctgc agtgcgaaga aactgaaaat      420

agagccctct ggctgggatg tttcaggaca gagtagcaac gacaaatatt atacccacag      480

caaaaccctc ccagccacac aagggcaagc caactcctct caccaggtag caaatttcaa      540

catccctgct tacgaccagg gcctcctcct cccagctcct gcagtggagc atattgttgt      600

aacagccgct gatagctcgg gcagtgctgc tacatcaacc ttccaaagca gccagaccct      660

gactcacaga agcaacgttt ctttgcttga gccatatcaa aaatgtggat tgaaacgaaa      720

aagtgaggaa gttgacagca acggtagtgt gcagatcata gaagaacatc cccctctcat      780

gctgcaaaac aggactgtgg tgggtgctgc tgccacaacc accactgtga ccacaaagag      840

tagcagttcc agcggagaag gggattacca gctggtccag catgagatcc tttgctctat      900

gaccaatagc tatgaagtct tggagttcct aggccggggg acatttggac aggtggctaa      960

gtgctggaag aggagcacca aggaaattgt ggctattaaa atcttgaaga accacccctc     1020

ctatgccaga caaggacaga ttgaagtgag catcctttcc cgcctaagca gtgaaaatgc     1080

tgatgagtat aattttgtcc gttcatacga gtgctttcag cataagaatc acacctgcct     1140

tgtttttgaa atgttggagc agaacttata tgattttcta aagcaaaaca aatttagccc     1200

actgccactc aagtacatca gaccaatctt gcagcaggtg gccacagcct tgatgaagct     1260

caagagtctt ggtctgatcc acgctgacct taagcctgaa aacatcatgc tggttgatcc     1320

agttcgccag ccctaccgag tgaaggtcat tgactttggt tctgctagtc acgtttccaa     1380

agctgtgtgc tcaacctact tacagtcacg ttactacaga gctcctgaaa ttattcttgg     1440

gttaccattt tgtgaagcta ttgatatgtg gtcactgggc tgtgtgatag ctgagctgtt     1500

cctgggatgg cctctttatc ctggtgcttc agaatatgat cagattcgtt atatttcaca     1560

aacacaaggc ttgccagctg aatatcttct cagtgccgga acaaaaacaa ccaggttttt     1620

caacagagat cctaatttgg ggtacccact gtggaggctt aagacacctg aagaacatga     1680

actggagact ggaataaaat caaaagaagc tcggaagtac atttttaatt gcttagatga     1740

catggctcag gtgaatatgt ctacagacct ggagggaaca gacatgttgg cagagaaggc     1800

agaccgaaga gaatacattg atctgttaaa gaaaatgctc acaattgatg cagataagag     1860

aattacccct ctaaaaactc ttaaccatca gtttgtgaca atgactcacc ttttggattt     1920

tccacatagc aatcatgtta agtcttgttt tcagaacatg gagatctgca agcggagggt     1980

tcacatgtat gatacagtga gtcagatcaa gagtcccttc actacacatg ttgccccaaa     2040

tacaagcaca aatctaacca tgagcttcag caatcagctc aatacagtgc acaatcaggc     2100

cagtgttcta gcttccagtt ctactgcagc agctgctact ctttctctgg ctaattcaga     2160

tgtctcacta ctaaactacc agtcagcttt gtacccatca tctgctgcac cagttcctgg     2220

agttgcccag cagggtgttt ccttgcagcc tggaaccacc cagatttgca ctcagacaga     2280

tccattccaa cagacattta tagtatgtcc acctgcgttt caaactggac tacaagcaac     2340

aacaaagcat tctggattcc ctgtgaggat ggataatgct gtaccgattg taccccaggc     2400

accagctgct cagccactac agattcagtc aggagttctc acgcagggaa gctgtacacc     2460

actaatggta gcaactctcc accctcaagt agccaccatc acaccgcagt atgcggtgcc     2520

ctttactctg agctgcgcag ccggccggcc ggcgctggtt gaacagactg ccgctgtact     2580

gcaggcgtgg cctggaggga ctcagcaaat tctcctgcct tcaacttggc aacagttgcc     2640

tggggtagct ctacacaact ctgtccagcc cacagcaatg attccagagg ccatggggag     2700

tggacagcag ctagctgact ggaggaatgc ccactctcat ggcaaccagt acagcactat     2760

catgcagcag ccatccttgc tgactaacca tgtgacattg gccactgctc agcctctgaa     2820

tgttggtgtt gcccatgttg tcagacaaca acaatccagt tccctccctt cgaagaagaa     2880

taagcagtca gctccagtct cttccaagtc ctctctagat gttctgcctt cccaagtcta     2940

ttctctggtt gggagcagtc ccctccgcac cacatcttct tataattcct tggtccctgt     3000

ccaagatcag catcagccca tcatcattcc agatactccc agccctcctg tgagtgtcat     3060

cactatccga agtgacactg atgaggaaga ggacaacaaa tacaagccca gtagctctgg     3120

actgaagcca aggtctaatg tcatcagtta tgtcactgtc aatgattctc cagactctga     3180

ctcttctttg agcagccctt attccactga taccctgagt gctctccgag gcaatagtgg     3240

atccgttttg gaggggcctg gcagagttgt ggcagatggc actggcaccc gcactatcat     3300

tgtgcctcca ctgaaaactc agcttggtga ctgcactgta gcaacccagg cctcaggtct     3360

cctgagcaat aagactaagc cagtcgcttc agtgagtggg cagtcatctg gatgctgtat     3420

cacccccaca gggtatcgag ctcaacgcgg ggggaccagt gcagcacaac cactcaatct     3480

tagccagaac cagcagtcat cggcggctcc aacctcacag gagagaagca gcaacccagc     3540

cccccgcagg cagcaggcgt ttgtggcccc tctctcccaa gccccctaca ccttccagca     3600

tggcagcccg ctacactcga cagggcaccc acaccttgcc ccggcccctg ctcacctgcc     3660

aagccaggct catctgtata cgtatgctgc cccgacttct gctgctgcac tgggctcaac     3720

cagctccatt gctcatcttt tctccccaca gggttcctca aggcatgctg cagcctatac     3780

cactcaccct agcactttgg tgcaccaggt ccctgtcagt gttgggccca gcctcctcac     3840

ttctgccagc gtggcccctg ctcagtacca acaccagttt gccacccaat cctacattgg     3900

gtcttcccga ggctcaacaa tttacactgg atacccgctg agtcctacca agatcagcca     3960

gtattcctac ttatagttgg tgagcatgag ggaggaggaa tcatggctac cttctcctgg     4020

ccctgcgttc ttaatattgg gctatggaga gatcctcctt taccctcttg aaatttctta     4080

gccagcaact tgttctgcag gggcccactg aa                                   4112


<210> 3026
<211> 2441
<212> DNA
<213> Homo sapiens

<400> 3026
accctgatca gggagtatcg gctgcgggtg cgcaaggcgt ccaggagtga cctggggctg       60

tggagagcga cccgtggcct tgtgtttcag gtacggaggt tccggactgg acgggcgtca      120

ggaagtcaca gacttgtcct ctgatgtggc cccgcccgcc gccgcactaa tctcttcggc      180

gtcgtacccg tcggcccagc tcgacccgcc gcagccccgg ccccgaccgt ggacactggg      240

ggtccccgag ggcgctgcga cctcctcccg ggtgaaatga aacccgaggg cagtccccct      300

taccgacccc attagagacg tatctgccgt gccaggggtc taggctccag aaacagggag      360

tttaccacct aggatgactt cagtgactag atcagagatc atagatgaaa aaggaccagt      420

gatgtctaag actcatgatc atcaattgga atcaagtctc agtcctgtgg aagtgtttgc      480

taaaacatct gcctccctgg agatgaatca aggcgtttca gaggaaagaa ttcaccttgg      540

ctctagccct aaaaaagggg gaaattgtga tctcagccac caggaaagac ttcagtcgaa      600

gtcccttcat ttgtctcctc aagaacaatc tgccagttat caagacagga ggcaatcctg      660

gcggcgagca agtatgaaag aaacgaaccg gcggaagtcg ctgcatccca ttcaccaggg      720

catcacagag ctcagccggt ctatcagtgt cgatttagca gaaagcaaac ggcttggctg      780

tctcctgctt tccagtttcc agttctctat tcagaaactt gaacctttcc taagggacac      840

taagggcttc agtcttgaaa gttttagagc caaagcatct tctctttctg aagaattgaa      900

acattttgca gacggactgg aaactgatgg aactctacaa aaatgttttg aagattcaaa      960

tggaaaagca tcagattttt ctttggaagc atctgtggct gagatgaagg aatacataac     1020

aaagttttct ttagaacgtc agacttggga tcagctcttg cttcactacc agcaggaggc     1080

taaagagata ttgtccagag gatcaactga ggccaaaatt actgaggtca aagtggaacc     1140

tatgacatat cttgggtctt ctcagaatga agttcttaat acaaaacctg actaccagaa     1200

aatattacag aaccagagca aagtctttga ctgtatggag ttggtgatgg atgaactgca     1260

aggatcagtg aaacagctgc aggcctttat ggatgaaagt acccagtgct tccagaaggt     1320

gtcagtacag ctcggaaaga gaagcatgca acaattagat ccctcaccag ctcgaaaact     1380

gttgaagctt cagctacaga acccacctgc catacatgga tctggatctg gatcttgtca     1440

gtgactttat gagagtttct gccacaaggt gcccaagagg agaggaatgg gaagagtgcc     1500

ccagcacgtg gtgactgcgt gatttctgct cgttgccttt gaagataact ggcaggactg     1560

actgtagaac actttgactt ttttcaaaaa gtgatggaat ttgtacatcc aaatgaatat     1620

tgtatagaca attttcccag gaatgtgcaa aatgcttgaa agttcaaact tcttttttga     1680

aatgatcttc agatccagtg gcccattctt ttatctttat cctgtgaagg tgtttttcag     1740

gttttgaaac aatccaaaaa tcatttagga ccaagtctaa ggaaacattt tagtggccaa     1800

gttggattcc gattgtaaag gaatgatact aattttctag catggctctg aaggtgattt     1860

taggtagaag agttttgagg ctgggcgcaa tggctcacgc ctgtaatcct agcattttgg     1920

gtgactgagg cgggtggatt gcttgagccc agaagttgaa gaccagcctg agaaataagg     1980

tgaaaccctg tctacaaaaa atacaaaaag ttagctgggt gtggtggcgt gtgcctgtag     2040

tgctagctac tcagaaggct gaggtgggag gattgtttga gcccaggagg ttgaggctgc     2100

agtgagttct aattgcgcca ctgcactcca gcctgagcga cagagtgaga cactgtctta     2160

aaaaaaatta aaaattgtaa aaaaatgaaa aaaaaagttt tgagcattat ttgcatcatt     2220

gggatacata tgtcacttca caagatgttc aatttgaagg aaataccact cattctctat     2280

gtcctgttgt ctgtagtgtg cttcagtttt tcatattgag ttgacctaaa tcctggattc     2340

atgacaagaa aggagtaagt actactattc attgttctat ttgtttataa tctgtattat     2400

aaaattgcac ataattaaaa gctttccctt gtcttcatct a                         2441


<210> 3027
<211> 2767
<212> DNA
<213> Homo sapiens

<400> 3027
cgagcgcggc gaggggcgca tgcagggccc cgacgcgcca ctgctcctga gcgcgaggga       60

gctggggccc gggcgccggg gctcggcctc ctggtaccgc caggagggcg gcgcggtgtg      120

caactggctg cggaagccgc agccgctcga gccacgcacc agtttcccct cggcgcgccg      180

ctccgagttc cgtccaccca ggaggctgcc atgggccggc cctgcctccg cccagtccga      240

ggagggtcac gcaggcggca gatgccaggc gggcagcccc gcccctgcgc gccgcctcag      300

cggcgccttc aagacgctgg tcccaggcac ccacgcccag ggcgcctcgg atacccaccc      360

cctcggcccc ccgcacaccc cggtcctcga cccctctccg caggatggtt tcccggtcct      420

ctggcgagga tcctccaagg cgtctcacat gaaccggctc agaaacgcca aaatctacgt      480

ggagagagct gtcaagcaga agaagatctt tacaatccaa ggctgctacc cggtgatccg      540

gtgtctcttg cgccggaggg gctgggtgga gaagaagatg gtccatcgct caggccccac      600

cctgctgcca ccccagaagg atctggatag ctcagcgatg ggtgacagtg acaccactga      660

ggatgaggat gaagatgagg acgaggagtt ccagccatca cagctgttcg acttcgatga      720

tttactgaaa tttgatgacc tagatggaac acatgctctg atggtgggtc tatgtctcaa      780

tctccggaat ttgccgtggt ttgatgaggt tgatgccaac tccttcttcc cacgctgcta      840

ctgcctgggg gctgaggatg acaaaaaagc cttcatagag gacttctggc tgactgctgc      900

ccgcaacgtt ctcaagctgg tggtgaagtc tgagtggaag tcatacccta ttcaggcagt      960

agaggaagag gcctcaggag acaagcagcc caagaaacag gagaaaaacc cagtgttggt     1020

gtccccagag tttgtggatg aagctctgtg tgcgtgcgag gagtacctta gcaacttggc     1080

ccacatggac atcgacaagg acctggaggc cccgctgtac ctcacccccg agggctggtc     1140

cctcttcctc cagcgctact accaagtggt ccacgaaggg gcagaactca ggcacctcga     1200

cactcaggtc cagcgctgtg aggacatcct gcagcagctg caggccgtgg taccccagat     1260

agacatggaa ggggatcgca acatctggat cgtgaagcca ggagccaagt cccgcggacg     1320

aggcatcatg tgcatggacc acctggagga gatgctgaag ctggtgaacg gcaaccccgt     1380

ggtgatgaag gacggcaagt gggtggtgca gaagtatatt gagcggcccc tcctcatctt     1440

tggcaccaag tttgacctca gacagtggtt cctggtaact gactggaacc cacttaccgt     1500

gtggttctac cgcgacagct atatccgctt ttccacgcag cccttctccc tgaagaacct     1560

ggacaactca gtgcacctgt gcaacaactc catccagaag cacctggaga actcatgcca     1620

tcggcatcca ctgcttccgc cagacaacat gtggtctagc cagaggttcc aggcccacct     1680

gcaggagatg ggtgccccaa atgcttggtc caccatcatc gtgcctggca tgaaggatgc     1740

tgtgatccac gcacttcaga cctcccagga caccgtgcag tgtcggaagg ccagctttga     1800

gctctatggc gctgacttcg tgttcgggga ggacttccag ccctggctga ttgagatcaa     1860

cgccagcccc acgatggcac cctccacagc agtcactgcc cggctctgtg ctggcgtgca     1920

agctgacacc ctgcgcgtgg tcattgaccg gatgctggac cgcaactgtg acacaggagc     1980

ctttgagctc atctataagc agcctgctgt ggaggtgcct caatatgtgg gcatccggct     2040

cctggtagag ggcttcacca tcaagaagcc catggcgatg tgtcatcggc ggatgggggt     2100

ccgcccagca gtccctctgc tgacccagcg aggctctggg gaagcccgtc accacttccc     2160

cagcctccac accaaggccc agctgccttc tccccatgta ctccgacacc agggccaggt     2220

cctcagacga cagcacagca agctggtggg cactaaggcc ctgtcgacca caggcaaggc     2280

cttgaggact ctacccacgg ctaaggtctt catttccctc ccaccgaacc ttgatttcaa     2340

ggtggcaccc agcatcctga agccaagaaa ggctcctgct ctcctgtgcc tccgaggccc     2400

ccagctggaa gtgccttgtt gcctctgccc tttgaagtcg gaacaattcc tagcacctgt     2460

cggaaggtca aggccaaagg caaattcaag gccagactgt gacaaaccca gggctgaggc     2520

ctgccccatg aagaggctga gccccctgaa acccctgccc cttgttggta cattccagag     2580

gcgcaggggc ctgggggata tgaagctagg gaagcccctg cttcgattcc ccactgccct     2640

tgtcctggat ccaacaccaa ataaaaagaa acaagtgaag tatttggggc ttgactccat     2700

tgctgttgga gggtcaagag tggatggggc gaggccgtgt accccagggt ccacagcaag     2760

agcctga                                                               2767


<210> 3028
<211> 3239
<212> DNA
<213> Homo sapiens

<400> 3028
ctttgaactc caagctgctc aagaaaaaga aaagcttaaa gttgaagatg agcctgaagt       60

cttgacagaa cctccaagtg ccacaaccac tactaccata ggtatatctg caacctggac      120

aactttggca ggttctcatg gtaaaagaaa taataccata actacaacca gttcaaagag      180

gaaaaacagg aaaaataaaa ttactccaga aaacgttcaa attatatttg atgatccact      240

accaatttca tacagtcagc cagagaaggt gaatggagag tccaagagca gcagtaccag      300

cgagagtggg gacagtgata acatgaggat ttccagctgc agcgatgaaa gtagtaacag      360

caacagcagt cgtaagagtg acaatcattc accagctgtg gtcactacca ctgtgagcag      420

caaaaagcag ccatcagttc ttgttacatt tccaaaggaa gagagaaaat ctgtttctgg      480

caaggcttca ataaaattgt cagaaactat cagtgaaggg accagtaatt ctctatctac      540

ttgtacaaaa tctggtccat ctcccctttc ttctccaaat gggaagttaa cagtagcaag      600

tcctaagcgt gggcaaaaga gggaagaagg atggaaagaa gttgtaagaa ggtcaaagaa      660

agtatctgtt ccatcaactg tgatatccag agtgattgga agaggaggct gtaatatcaa      720

tgctattcgg gagtttactg gtgcacacat agatattgat aaacagaaag acaagactgg      780

agaccggata atcactataa ggggtggcac tgaatcaaca agacaagcaa ctcaattgat      840

taatgctttg atcaaggatc cagacaaaga aattgatgaa cttattccaa agaatcgttt      900

gaaaagctcc tcagcaaatt ccaaaatagg gtcatcagca cctaccacca ctgctgctaa      960

cacttcctta atgggaatta aaatgacaac tgtagctctg tcatcaacat ctcaaactgc     1020

cacagcactc actgtgcctg caatttcttc tgcatccact cacaaaacca ttaagaaccc     1080

agtgaataat gtgaggcctg gttttccagt ttctcttcca ttagcatatc ctcctccaca     1140

gtttgcacat gctttgcttg ctgctcagac tttccagcag atccgtccac caaggttgcc     1200

catgacccac tttggaggta cttttccacc agctcaatcc acttggggtc cgtttcctgt     1260

caggcctttg agccctgcca gagctactaa ctcgcctaag cctcacatgg tgcctcgcca     1320

tagcaatcag aatagcagtg gttctcaggt gaattcagca ggttctttaa cttcaagccc     1380

aacaactaca accagttcat cagcttcaac ggtgcctggt acatctacaa atggcagtcc     1440

aagttcacct tctgtccgaa ggcagctttt tgtcacagtt gtgaagacat ccaatgccac     1500

cacaacaaca gtcacaacca cggcaagcaa caacaacact gcacccacaa atgccacata     1560

tcctatgcct actgccaaag aacactatcc agtatcatcc ccatcttccc catcaccacc     1620

agcccagcca ggaggggttt ctagaaacag ccctttggat tgtggatcag catctccaaa     1680

taaagtggca tcttcctccg aacaggaagc aggtagtcca ccagtagtag aaacaacaaa     1740

cactagacct ccaaacagca gcagttcttc tgggagttca tcagctcatt ctaatcagca     1800

acaacctccg ggatctgttt ctcaggaacc aagaccacct cttcagcagt ctcaggttcc     1860

tcccccggaa gttagaatga ctgttcctcc tttagcaaca agttctgctc cagtggcggt     1920

gccttctact gccccagtga cttaccctat gcctcagaca ccaatgggat gcccccagcc     1980

tactcctaaa atggaaaccc ctgctattag accaccccct catggcacaa ctgcccctca     2040

caagaattca gcttcagtgc aaaattcatc tgttgcagtc ctcagtgtca atcacattaa     2100

aagacctcac agtgttccct cttctgtcca gctaccttcg accttaagta cacaaagtgc     2160

ttgtcagaat tcagtacatc cagcaaataa gcctattgct cccaatttca gtgccccctt     2220

accatttggg ccctttagca cattgtttga aaacagccct acttctgctc atgccttctg     2280

gggaggatct gttgtttcat ctcagtcaac accagaatct atgctatcag gaaaatcctc     2340

atatttgcca aattcagatc ctttacatca gtctgatact tccaaagctc caggttttag     2400

accaccatta cagagacctg ctccaagtcc ctcaggtatt gtcaatatgg actcgccata     2460

tggttctgta acaccttctt caacacattt gggaaacttt gcttcaaaca tttcaggagg     2520

tcagatgtac ggacctgggg caccccttgg aggagcaccc gcagctgcta actttaacag     2580

acaacatttt tccccgctta gtttgttgac tccgtgttca tcagcatcaa atgattcttc     2640

tgcacagtca gtatcctcgg gagttcgtgc accatctcct gccccatcat cagtaccgtt     2700

agggtcagaa aagcccagca atgtgtctca ggacatagtg gcatctggtc ctttgaaggg     2760

attggtggca atcaagacaa agtagactgg tgtaaccctg ggatgggaaa tcctatgatc     2820

cacagaccga tgtctgaccc aggagtattt tcacaacatc aagcaatgga gcgagatagt     2880

acaggaattg taactccttc tggtacattc catcagcatg ttcctgcagg ctacatggac     2940

tttcctaaag ttgggggtat gcctttttct gtgtatggga atgcaatgat tcctccagta     3000

gcacctatcc ctgatggtgc tggaggaccc atatttaatg gccctcatgc tgcagaccct     3060

tcttggaact cactgataaa gatggtttcc agctccacgg aaaataatgg ccctcaaacg     3120

gtgtggactg gaccctgggc acctcacatg aacagtgtgc atatgaacca gcttggctga     3180

tgaggatcag cttgttagcc tgcagattcc ttttcatttg gaggaaatca caagtggcc      3239


<210> 3029
<211> 7593
<212> DNA
<213> Homo sapiens

<400> 3029
gaggcggtgg cggcggaggc ggcaccgatt gctgtgtcgg ccccagtgcg gccgaagtcg       60

cggtagagcg tagccccacg cccctccccc gtccgcgccc tccctctttc cctggggatg      120

gagaaggcga cggttccggt ggcggcggcg acggctgcag aaggagaagg gagccccccg      180

gcggtggcgg ctgtggcggg cccccccgcg gcggcggagg tcggcggcgg cgttggcggc      240

agcagcagag ctcgctcggc ctcgtctcct cgtgggatgg tgcgagtctg cgacctgctc      300

ctgaagaaga agccgccgca gcagcagcac cacaaggcca agcgtaaccg gacttgccga      360

ccccccagca gcagcgaaag cagcagcgac agcgacaaca gcggcggcgg tggaggcggc      420

ggtggaggcg gaggtggcgg cggcggcacc agcagtaaca acagcgagga agaagaggac      480

gacgacgacg aggaagagga ggtttctgag gtggagtctt tcattttgga tcaggatgat      540

ttggaaaatc caatgctgga aacagcttcc aagttgctct tatcaggtac tgctgatggt      600

gcagacctca ggacagtaga tccagaaaca caggctagac tggaagcttt actagaagct      660

gcaggaatag gaaaattgtc cacggctgat ggtaaagcct ttgcagatcc tgaagtactt      720

cggaggttga catcgtctgt tagttgtgcg ttggatgaag ctgctgctgc acttacccgt      780

atgagagctg aaagcacagc aaatgcaggg cagtcggaca accgcagttt ggcagaagcc      840

tgttcagaag gagatgtaaa tgctgtgcga aagttactca ttgaagggcg aagtgtaaat      900

gaacacacag aggaagggga gagcctcctt tgtttagctt gttctgctgg atactatgag      960

cttgcacagg ttttgttggc aatgcatgca aatgtggaag ataggggaat caaaggtgac     1020

attacacctt taatggctgc tgctaatgga ggacatgtca aaattgtgaa gttgctgcta     1080

gctcataaag cagatgttaa tgcacagtct tcaacaggca atacagcact tacatatgct     1140

tgtgctggag gctatgtaga tgttgtaaag gtgctcttgg aatccggtgc tagtattgag     1200

gaccataatg aaaatggtca tacccctctt atggaagctg gaagtgctgg acatgtggaa     1260

gtagccagat tgctgctaga aaatggggct ggcattaata cgcattctaa tgaatttaaa     1320

gagagtgccc ttaccttagc ttgttacaaa ggacacttag agatggtgcg atttcttttg     1380

gaagcaggcg cggatcaaga gcataaaaca gatgaaatgc acactgctct gatggaggct     1440

tgcatggatg gccatgttga agtagctagg ttacttcttg acagcggtgc ccaagtgaac     1500

atgcctgctg attcatttga gtcaccatta actttggctg catgtggtgg gcatgtggaa     1560

cttgcggctt tacttattga aagaggagct agcctggaag aggtcaatga tgaaggttat     1620

acaccattga tggaagcagc tcgagaagga catgaagaaa tggtggcatt acttcttggt     1680

caaggagcaa atatcaatgc acagacagaa gaaactcaag aaactgcctt gactctggct     1740

tgctgtggag gctttctgga agtggcagac tttctaatta aggcaggagc cgatatagaa     1800

ctagggtgtt ctaccccttt aatggaagct gctcaagagg gtcatttgga gttagttaaa     1860

tacttattag ctgcaggagc taacgttcat gcaacaacag caacagggga tacagcacta     1920

acatatgcct gtgaaaatgg tcatactgat gtagcagatg tcttacttca ggcaggcgca     1980

gatctggaac atgaatctga aggtggaaga actcctttaa tgaaagctgc aagagctggt     2040

catgtttgta ctgttcagtt cttaattagt aaaggagcga atgtgaatag aaccacagct     2100

aataatgacc atactgtact gtccctggct tgtgcagggg gtcatctggc agtggtggaa     2160

ctacttttgg ctcatggggc agatcctact caccgtttga aagatggctc aactatgttg     2220

atagaagcag caaaaggtgg ccatacaagt gttgtttgct atctcttgga ttatcctaat     2280

aacttgcttt cagcccctcc accagatgtc actcagttaa ctcccccatc ccacgattta     2340

aatagggctc ctcgtgtacc agttcaagca ctgcccatgg ttgttccacc tcaggagcct     2400

gacaaaccac ctgccaatgt tgccaccact cttcccatca ggaataaagc tgcttctaaa     2460

caaaagtcca gcagccattt gccagcaaac agccaggatg tacagggtta catcaccaat     2520

cagtctccag agagcattgt agaagaggct cagggaaagt taacagaact ggaacagagg     2580

ataaaagaag ccatagaaaa gaatgcacag ctgcagtcct tggaactggc tcatgctgac     2640

caacttacca aggagaagat cgaggagctc aacaaaacaa gggaggaaca aattcagaag     2700

aaacaaaaga ttttggagga actacagaaa gtagaacgag agttacaact gaaaactcag     2760

cagcagctaa aaaagcagta tctagaggtt aaagctcaaa gaattcaact tcagcaacag     2820

cagcaacagt cttgccaaca cctgggatta ctaactcctg ttggagttgg agagcagctt     2880

tctgagggag actatgcacg gttacagcaa gtggatcctg ttttacttaa agatgaaccc     2940

cagcagactg ctgctcagat gggttttgcg ccaatccagc ctctggcgat gcctcaagct     3000

ttgcctctgg cggcaggtcc cttgcctcca gggtccatcg caaatcttac agaactgcaa     3060

gtcctatcat ctctccttca gccatgcttc ctatctaccc tgccattgat attgatgcac     3120

agactgagag taatcatgac acggcccaag agcagcagta ccagcgagag tggggacagt     3180

gataacatga ggatttccag ctgcagcgat gaaagtagta acagcaacag cagtcgtaag     3240

agtgacaatc attcaccagc tgtggtcact accactgtga gcagcaaaaa gcagccatca     3300

gttcttgtta catttccaaa ggaagagaga aaatctgttt ctggcaaggc ttcaataaaa     3360

ttgtcagaaa ctatcagtga agggaccagt aattctctat ctacttgtac aaaatctggt     3420

ccatctcccc tttcttctcc aaatgggaag ttaacagtag caagtcctaa gcgtgggcaa     3480

aagagggaag aaggatggaa agaagttgta agaaggtcaa agaaagtatc tgttccatca     3540

actgtgatat ccagagtgat tggaagagga ggctgtaata tcaatgctat tcgggagttt     3600

actggtgcac acatagatat tgataaacag aaagacaaga ctggagaccg gataatcact     3660

ataaggggtg gcactgaatc aacaagacaa gcaactcaat tgattaatgc tttgatcaag     3720

gatccagaca aagaaattga tgaacttatt ccaaagaatc gtttgaaaag ctcctcagca     3780

aattccaaaa tagggtcatc agcacctacc accactgctg ctaacacttc cttaatggga     3840

attaaaatga caactgtagc tctgtcatca acatctcaaa ctgccacagc actcactgtg     3900

cctgcaattt cttctgcatc cactcacaaa accattaaga acccagtgaa taatgtgagg     3960

cctggttttc cagtttctct tccattagca tatcctcctc cacagtttgc acatgctttg     4020

cttgctgctc agactttcca gcagatccgt ccaccaaggt tgcccatgac ccactttgga     4080

ggtacttttc caccagctca atccacttgg ggtccgtttc ctgtcaggcc tttgagccct     4140

gccagagcta ctaactcgcc taagcctcac atggtgcctc gccatagcaa tcagaatagc     4200

agtggttctc aggtgaattc agcaggttct ttaacttcaa gcccaacaac tacaaccagt     4260

tcatcagctt caacggtgcc tggtacatct acaaatggca gtccaagttc accttctgtc     4320

cgaaggcagc tttttgtcac agttgtgaag acatccaatg ccaccacaac aacagtcaca     4380

accacggcaa gcaacaacaa cactgcaccc acaaatgcca catatcctat gcctactgcc     4440

aaagaacact atccagtatc atccccatct tccccatcac caccagccca gccaggaggg     4500

gtttctagaa acagcccttt ggattgtgga tcagcatctc caaataaagt ggcatcttcc     4560

tccgaacagg aagcaggtag tccaccagta gtagaaacaa caaacactag acctccaaac     4620

agcagcagtt cttctgggag ttcatcagct cattctaatc agcaacaacc tccgggatct     4680

gtttctcagg aaccaagacc acctcttcag cagtctcagg ttcctccccc ggaagttaga     4740

atgactgttc ctcctttagc aacaagttct gctccagtgg cggtgccttc tactgcccca     4800

gtgacttacc ctatgcctca gacaccaatg ggatgccccc agcctactcc taaaatggaa     4860

acccctgcta ttagaccacc ccctcatggc acaactgccc ctcacaagaa ttcagcttca     4920

gtgcaaaatt catctgttgc agtcctcagt gtcaatcaca ttaaaagacc tcacagtgtt     4980

ccctcttctg tccagctacc ttcgacctta agtacacaaa gtgcttgtca gaattcagta     5040

catccagcaa ataagcctat tgctcccaat ttcagtgccc ccttaccatt tgggcccttt     5100

agcacattgt ttgaaaacag ccctacttct gctcatgcct tctggggagg atctgttgtt     5160

tcatctcagt caacaccaga atctatgcta tcaggaaaat cctcatattt gccaaattca     5220

gatcctttac atcagtctga tacttccaaa gctccaggtt ttagaccacc attacagaga     5280

cctgctccaa gtccctcagg tattgtcaat atggactcgc catatggttc tgtaacacct     5340

tcttcaacac atttgggaaa ctttgcttca aacatttcag gaggtcagat gtacggacct     5400

ggggcacccc ttggaggagc acccgcagct gctaacttta acagacaaca tttttccccg     5460

cttagtttgt tgactccgtg ttcatcagca tcaaatgatt cttctgcaca gtcagtatcc     5520

tcgggagttc gtgcaccatc tcctgcccca tcatcagtac cgttagggtc agaaaagccc     5580

agcaatgtgt ctcaggacag gaaagttcca gtccctattg ggactgaacg ttctgcacgt     5640

atcaggcaaa ctggaacgtc agctccatct gttattggga gcaatttgtc tacatcagta     5700

ggacatagtg gcatctggtc ctttgaaggg attggtggca atcaagacaa agtagactgg     5760

tgtaaccctg ggatgggaaa tcctatgatc cacagaccga tgtctgaccc aggagtattt     5820

tcacaacatc aagcaatgga gcgagatagt acaggaattg taactccttc tggtacattc     5880

catcagcatg ttcctgcagg ctacatggac tttcctaaag ttgggggtat gcctttttct     5940

gtgtatggga atgcaatgat tcctccagta gcacctatcc ctgatggtgc tggaggaccc     6000

atatttaatg gccctcatgc tgcagaccct tcttggaact cactgataaa gatggtttcc     6060

agctccacgg aaaataatgg ccctcaaacg gtgtggactg gaccctgggc acctcacatg     6120

aacagtgtgc atatgaacca gcttggctga tgaggatcag cttgttagcc tgcagattcc     6180

ttttcatttg gaggaaatca caagtggccg aaaaaaaaaa ttatgctccc aaatcattct     6240

actgatgtgc ttgactgaag tgtgtaggct ttttgcagaa gatcttacta actgacctat     6300

tttctgtgaa catttgtgac tgcccattcc ccatcatcat ccgttttacc ttagttagca     6360

tttttcttat catttttctt tttttctttc cctcttcccc tttggacata actttctgtt     6420

gaagctgttc tttggctggt tggttttagt actgtaaact gcttctgagc aaacacggaa     6480

atttagcaaa attatgtaaa cttgatcctg aagttttaga atggcaaata aatgtacaat     6540

tgtttacata acagaaaagg ctaagcagaa agtaaatttc aatatgtcag tatagaggct     6600

ctactttatg tagacttaaa ttaatgtgag atatgtacct tcatattcag aaatctggat     6660

gtttccttca tacattaaac tattaataag cataactttt ctactggtgt aatttaagta     6720

taaagtaaaa taatgggcat tatcattgga tgtttcccca cattggcttt taaaataccc     6780

atcttgcttt ctttttggtt tatttgtagc aaggcacata tagaagaaga aatttctggc     6840

ttttccatgt tgttttatta ccttttctca cttttaaaac taatacagac ttatctcctc     6900

actccttttt ctctccttac ctttaccact aataccagta aaattatctt tctgatagtg     6960

aaaaggttct gtcaagattt tcactgtaat ggctgctaca gagatggacc atcttcatca     7020

tcaccagtgg tttcttctaa ttataaaatg tttaaacttt ctgagaattt aaaaagccac     7080

cactgttccc agtcagcata tacaagctct taatattctg tttattaaat aattcaatgt     7140

actattttat attggatgat attgattctt aacattggct tttcagtcat caacagtcaa     7200

cataaaaatt tcaattttca gtaatttagt ggaaaatatc ttatttcttt tttcaatttt     7260

aaaggcttcc tgctttttta cccttgtata ttatcagtga aaaggatcaa cagttaattt     7320

gagccaagta ataaaagaaa ttctgcattt gtcacgaaga caatttatgg tagacagata     7380

aatacacaga ttacagtgta aagtctccat ttaacctgtt tataaaagat acaaggccac     7440

actaaactac tcagtgggat ttatatattc catccacttg aaacaataaa cagtaatgta     7500

tccaagaaga ttatgtgtcc taccctgtct catggaaaaa ttaattatat ggttgaaatg     7560

taaaagaaag taagcataaa aatcgagtaa tgt                                  7593


<210> 3030
<211> 3546
<212> DNA
<213> Homo sapiens

<400> 3030
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact     1560

catatcaacc caagtaccat gtggacttga tccctggctg aatcacctgg atgacttgga     1620

atagaaatga ctgctttaga agatgggatg gggccgggtg gtaagggata gaagagagga     1680

ctctcaatct actgatcaag tcctttcccc aatgcccagt ggatggccag ggtacctggg     1740

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1800

tagaaagggc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1860

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1920

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1980

agtgtggtgg ccactggtga cttgaaaata tagagaaaaa aaaaacctgc tctatatctg     2040

aaagagctct tgggaagaca gagaaacata aagaggaaat tacagcacag tgtggtgggt     2100

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     2160

ggaaggagag ggtgagtggg ggatggcttt ctgaaaaggg tggtctaaag gatgcctatg     2220

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     2280

ggatgacctg tgactctgga gcactgggtt gtctccattg tcattatggg cagatgtgtg     2340

ccatccccag ccgacgccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     2400

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     2460

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     2520

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2580

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaacttta     2640

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2700

ggaatagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2760

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gtgtaaacta     2820

caatgctctg tcatctccct actgggtctc ctgggaggag gggagccatc cagggtgcaa     2880

actcaaaggc agagggcaca gcgtgcttag gcccaagctt agaattcaat tgagaagttc     2940

tgttgttcat ccttacctca gcaggtagaa aagaggtgga gatcagaagc cagggattag     3000

agattgaatt gctttccctg ggagtgtgca gtatctcatt aaaatgttgt atattcaaaa     3060

aaatacagac acacacaagt gcctatataa tgataaaaca tatccaaagc acccaaacct     3120

gtgattccag aaaagtagat cctatttttg tttattttta ttggctttag ctgtgtcttt     3180

tgaaaggact attatcctct aaaatgtatg tgtatgaaga tcctggcttg cagctcggga     3240

gctttacaca ccttgtgtca ctttatcttg gtaacgagcc aagatcatgc aaccagttca     3300

tccatgtctg acccaagagc tcttaactgc tatgctgcac tgcctcattc agagatagat     3360

gcctgcatgg gtcctggcga ttattttaat gctggctaca cccccacagg tgacttggat     3420

tcagaaatac aatttatatt tcttcttttt aaattgtttt attttatttt tcttttaata     3480

gttatatgtc agtgagaaca atttatatgt cttacactga gaaataaaac tgctcataag     3540

tgaaaa                                                                3546


<210> 3031
<211> 4726
<212> DNA
<213> Homo sapiens

<400> 3031
gtcacttccg gtcgacggcg gaaggcggaa ggcggagcgg tccctgcaac ccggccggcg       60

ggaactgcct tctagttttt agtctcagac cagaccaccg ggcgcacccc gatgccgagc      120

ccgcagcttc tggtgctctt cggcagccag acaggcacgg ctcaggatgt gtcggagaga      180

ctgggtcgcg aggcccggcg ccggcggctt ggctgccggg tgcaggccct ggactcctac      240

ccggtggtga atctgattaa cgagcccctg gtgatatttg tttgtgcaac tacaggccaa      300

ggagaccccc ctgacaacat gaagaacttc tggaggttta tattccggaa gaacctgccc      360

tccactgccc tctgtcagat ggactttgcc gtcctgggcc tcggggactc ctcatacgcc      420

aagttcaact tcgtggccaa gaagctgcac cgacggctac tgcagcttgg gggcagcgcc      480

ctcctgcccg tgtgcctggg cgatgaccag catgagctgg gcctgccctc caagttcacc      540

ctgctgttcc tccaagaggc acccagcacg ggctctgagg ggcagcgggt agctcacccc      600

ggctctcagg agcccccgtc agagtcgaag cccttcctag cacccatgat ctccaaccag      660

agagtcaccg gcccctccca cttccaggac gttcggctga ttgagtttga catcttgggc      720

tctggcatca gctttgctgc tggtgatgtg gtgctgattc agccctccaa ctcggctgcc      780

catgtccagc ggttctgcca ggtgctgggc ctggaccctg accagctctt catgctgcag      840

ccgcgggagc cagatgtctc ctcccccacg aggctgcccc agccctgctc catgcggcac      900

ctcgtgtccc actacctgga catcgccagc gtgcctcgcc gctccttctt cgaactcctg      960

gcctgtctat ccctccatga gctggagcgg gagaagctgc tggagttcag ttctgcccaa     1020

ggccaggagg agctctttga atactgcaac cggccccgca ggaccatcct ggaggtgctc     1080

tgtgacttcc cgcacacagc tgccgccatc cctcccgact acctgttgga cctcatcccc     1140

gttatccggc cgagggcctt ctccatcgcc tcctcgctgc tgactcaccc ctcacggctg     1200

cagatcctcg tggctgtagt gcagttccag actcgcctca aggagccccg ccggggcctc     1260

tgctcctcct ggctggcatc cctggaccct gggcaaggac ctgtccgggt gcccctctgg     1320

gtgcggcctg ggagtctggc cttcccagag acaccagaca cacctgtgat catggtgggg     1380

cctggcactg gggtagcccc cttccgagca gccatccagg agcgtgtggc ccagggccag     1440

actggaaact tcttgttttt tggctgccgc tggcgggacc aagacttcta ctgggaggct     1500

gagtggcagg agctggagaa gcgggactgt ctgaccctca tccctgcctt ctcccgggaa     1560

caggagcaga aagtatatgt gcagcaccgg ctccgggagc tggggtcgct tgtgtgggaa     1620

ctgctggacc gccaggcaac gccaagtcca tgccagcgga cgtctcggaa gccctgatgt     1680

ccatcttcca ggaggagggt ggactctgca gcccggacgc agccgcgtat ctagccaggc     1740

tccagcagac acggcgcttc cagacagaga cgtgggcctg aggcccgcgg ctgcccgtgc     1800

cccctctgac agccatcctc ctgggagccc aggaaggcat ccacgaggga gctcctggcc     1860

agcagccgtc atcctctcgg accagccagc tggtcctctg ggaacagcca gctcccgagc     1920

acagccgcac tcctgttgac cctggatccc accctttgag cctgacccca ctgcagcctc     1980

tgcccagcca gccctgcgct cccccaccct gacagtgagc tgtgtcctcg tccccccacc     2040

cccttcccag tcaaggtggt ggcctgggcc gctccacctc accggtgcag tgacccagga     2100

cggcatcagc agcccagtga gcaccagggg tggcataggg cacccatgag gctgcgctgc     2160

actcctctgc cctggggcca cctcggctgc tgcagcctgc ccagcagcac attccagtca     2220

ctgcccccgc actcccacag ggctcaggct gggctcagag gccactgaga tgccagctcc     2280

ttgagagcag tgggggtgtc ccaggccaga gcagcctctt cctctcctgg tcccagaaaa     2340

acccttgcag taaatggtgg cctctgggtg gttacttcta gcgcaggctt ccttccttcc     2400

tctagctcct cccggtgccc tgggtgctgg gtgctggatg gatgggcgtc ctctagctcc     2460

tcccggtgcc ctgggtgctg ggtgctggat gggtgggcgt cctctagctc ctcccggtgc     2520

cctgggtgct gggtgctgga tgggtgggcg ccacggtgca cccttgttgg gctgcctgtg     2580

cccgagtggc ctctgcagct cttatgtctg cctctaatgg gatgtgcgcc ctgactgcct     2640

cgttcttaag ggcatagtgg gtcggctaag atctgatcgc caggactgcg ttctgggcag     2700

gtgctgggaa ggcggaacca agccgtccgt gccgctaggg agccgagact gccggaaaga     2760

ggagcggcag gagggggcgt ggttgtgcag ccccaccccc gggaggggct ttaggcactg     2820

ggaaggaaag tcctgttgga ggagttcggt ggctgttcac acccgcctcg ctgtcttgga     2880

gtcttgatct gtcgtcggcg ggtcgctggc acaggactaa acatggctga ggctgggctc     2940

cagccagatc tggctgggga cagcaccgcg tgggcccagg atccacccag agcaggcagg     3000

ccttgctggg gccccagtca agtccacttc cagtgaggag agccagccgg gaggtcagtg     3060

ccagagctct ggtggagccc agaccctgcc ttccctgagg gccgcccctg tcgccgccct     3120

ggggtccctg tcctcctatc ctgactcctg ccccagggcc accacccctg aactgtgccc     3180

tggggccccc accctccacc tggccgactc cagctctggg cctgtcagtc cacctgggtc     3240

ctctctgggc cctgagtgcc tggaccctct gtgccaagca ccagcaagca aaggggatga     3300

ccttgggcac ccccaaggtg ctgagactac agccagtgag cccctgctgg gggccaaagc     3360

catggagggt gcctgggccc ttccaacctg gaaggaggag gggagagagc aggcagcagg     3420

gcagggggaa gaggaggagt gcccgatctg cacagagccc tacgggccca gagagcgccg     3480

cctggccctg ctgaactgta gccacggcct gtgtgtgggc tgcctgcaca ggctgctggg     3540

ctcggcctcc agtgccgacc tgggccgggt gcgctgcccg ctgtgccgcc agaagacgcc     3600

cgtgctggaa tgggagatct gccggctaca ggaggagctg ctacaggccg acgggccctc     3660

acgccagccc cgccgagagg cccctgcatc ctatcaccgc aaccctgggc cctggggctc     3720

cctggagcac cgctaccagc tgcgcttcct ggcagggccc gtgggcggcc ggggctgcct     3780

gcccttcctg ccctgtccac cctgcctggg tgcccggctc tggaccctgc gggagcgggg     3840

accctgtgcc cgccgcctgg cgctgctgag cctgctggcc cttgagcttc tggggctgct     3900

gctggtcttc acgccgctcc tgctgctggg actgctcttc gtgctcctgg accgctctgg     3960

ccgctgagca gagcccagga cagccccgcc gccaacaggc cagggggccc agactggccc     4020

acgtccccat gcctgggtgc tgtgaggcct gatgaccagg ctggaaaaac ccaaggttgg     4080

gtccagggca ggggccttca atcaagacct cccattgctg aacccacaac cagggctacc     4140

cagaggcctg accctgccag agtccatggc tgcactgctg cccagacact agctgaaccc     4200

aaggacacca gcgcccaagg acagctcctg gaggaggcca gcccagcagg aaagtctgtg     4260

agcaggaccc cattcaccct gcggcagacg ggcaccgtac tggccacggg ctgacgccgg     4320

ccacacttcc cctccgaggg ccagctgagc acagcaggca tgaaagcaaa cagagataca     4380

gcagtgagtc agttccttgg agagggcagg gactccgccc accctgtgtt cagataaggg     4440

ccagtgtgtg tccctgaagg tcaggccagc cgggggaggg gtccatgctg cgaaaattca     4500

gcctgcaaag gctcctctcc ccacttgatc aggcccagac caggtggggg ttggcgctgg     4560

cctgtgttgc aggggacaag ggcccaccca ggccttggaa cataagctct gcccctgcac     4620

accctcatgt caccacacct gggatggaga catcaggtgg cccagcgaga gatggaggac     4680

tgatcctgga acgtgaagca gctttcaata aaccagctcc tgggga                    4726


<210> 3032
<211> 2119
<212> DNA
<213> Homo sapiens

<400> 3032
ggcagccctc cccagtggag ccccgaggac ccttttattt ctgcaggtta ttgcttgatg       60

acttgggaat gaattcttgg gacagaagga agaattttca tctattgaag aaaaattcaa      120

aattattgag agagctgaaa aatttggact cccgccagtg ccgtgagaca cacaaaatcg      180

cagtgtttta cattgctgaa ggtcaagaag acaagtgttc aatcctctct aatgaaagag      240

gaagccaagc atatgaagac tttgttgctg gacttggatg ggaggtggat ctctccaccc      300

actgtgggtt catgggtggc cttcagcgca atggcagcac cgggcagacg gccccttact      360

atgctacctc aactgtggaa gtgattttcc atgtttccac tcgaatgccg tcagactcag      420

atgattccct caccaaaaag cttcgtcact tggggaatga cgaggtccat atcgtctggt      480

ctgaacactc cagagactac cgcaggggta ttatcccaac tgcctttgga gatgtttcaa      540

tcattattta cccaatgaag aatcacatgt tcttcatcgc gataacgaag aaacctgagg      600

ttccattttt tgggcctctg tttgatggag ccatagtgag tgggaagctg ctgccaagcc      660

ttgtatgtgc cacgtgcatc aacgccagca gggctgtgaa gtgcctcatc ccactctacc      720

agagcttgta tctttttgct ttaaatgtgt aacttactaa ccatcccaga atcaagattc      780

ctggcagttt ttcataagag gtaagtattc aaaactgaat tgaagaggga agagaatttt      840

tttcaacctc tgttaaaaat aacatagtgg tttttcatag catttgttaa tttatattaa      900

atataataat tttatgctgc attaaactta gagtttactt tcataattta ctcacatacg      960

tttgtgtctg agaagctgtg accattatga gatgctcata tcttcttagg tattttgccc     1020

cacgttcagt ctcatcctgt atccctctta tttgtggcag tccattgtat ataaggtggg     1080

atgctgagca aaacgtatcg ctcattcaga gtgcctacca gaaaccaaag caaatgaaat     1140

gaccctaata aatcaaagaa tgtggcaggt accacctgag aagtgcaagt aggtttctgg     1200

aagatcagag gagatagaaa ttgcatttgg ttgagggtag agggaaagat gtcctgaatt     1260

aagttgcatt tggacttatc aataggaata gctagaaatt cttttgtaat tttcccaaat     1320

cattgatatt ttctctagtt cctgattttg tttccaaaaa cagaataaat ttcactccta     1380

aaattttttc ctcaaacatt aattggcctg ctgtagtcct taaattcaag catgatctca     1440

agttataaga aaaagagatt aagatgggtg accttataaa attgatgcaa aaaaagtgac     1500

ctcctaataa aacttagaat ctctttgttt ctaattggta ttgataataa tttgaaacat     1560

attgtgtttg acctctatat atacttctcc caacctgata gtaagtgatg tgttgctata     1620

gcaagtgaga gttgggggta gatgaaaact atcccatgtg aatagatacg gttcatgaaa     1680

aaataccttt cattaaaatc ctggtcactt cattgactga tattctgcct ttagattaaa     1740

aaaaaataca tatgccatgt ggcaacttaa aattatcata gaaatgagta gtagaaaaga     1800

gctattaggt cccatctggt ccctcccctg ggggccaggg caggattatt cccttcagtg     1860

tactctctcg tgctttgtcc aggctggtgg tgagtgtttt ggagatggca ttctttgcag     1920

tgatttccac aacactgtag acgtaatctt gtggctggtg tcaatttggc cttcagcatg     1980

gagtttttat ttcacatact attaaaaaga gcctcttggc agaaatgaga aagaactatt     2040

cagcgattag tttgtcagtt tgcatgtcaa ctaggacgag ctgggcacgc atcagtcaag     2100

tatgttggac caaggcagc                                                  2119


<210> 3033
<211> 562
<212> DNA
<213> Homo sapiens

<400> 3033
gttgtgagct gcggcagaga ctggtggctg gaggagacgc cggcgctgga gagtgcgctg       60

cgccgcccgc cgctgaggga ccgcggggtt agccactgct ggctgcttcc agtgttcgcc      120

gagaggtacc gggggtgaca gctccgggac cggccgaaag ccacataaag aagatcccta      180

atagtcattt ctcaacaatt atatagtcaa ctgatgtaac aatggtacta atattgggac      240

gcagactaaa cagagaggat cttggggtgc gtgattcccc agcaactaag cgaaaagttt      300

ttgaaatgga ccccaaatct ctgacaggtc atgagttttt tgacttctct tcaggatcat      360

cccatgccga aaacatactc cagatattta atgaatttcg tgatagccgc ttattcacag      420

atgttatcat ttgtgtggaa ggaaaagaat ttccttgcca tagagctgtg ctctcagcct      480

gtagcagcta cttcagagct atgttttgta atgaccacag ggaaagccga gaaatgttgg      540

ttgagatcaa tggtatttta gc                                               562


<210> 3034
<211> 1958
<212> DNA
<213> Homo sapiens

<400> 3034
cctggagttc cggccaggcc actgcttggg aagcaagaag gtgaaggcac ctctgctggg       60

ccaagcactc ttagggccga ggggcactgc agctgacaag agctccctgt ttcgctgagg      120

cctggagccc ccatggcctc actgagccga gccctacgtg tggctgctgc ccaccctcgc      180

cagagcccta cccggggcat ggggccatgc aacctgtcca gcgcagctgg ccccacagcc      240

gagaagagtg tgccatatca gcggaccctg aaggagggac agggcacctc ggtggtggcc      300

caaggcccaa gccggcccct gcccagcacg gccaacgtgg tggtcattgg tggaggcagc      360

ttgggctgcc agaccctgta ccacctggcc aagctgggca tgagtggggc ggtgctgctg      420

gagcgggagc ggctgacctc cgggaccacc tggcacacgg caggcctgct gtggcagctg      480

cggcccagtg acgtggaggt ggagcttctg gcccacactc ggcgggtggt gagccgggag      540

ctggaggagg agacgggact acacacgggc tggatccaga atgggggcct cttcatcgcg      600

tccaaccggc agcgcctgga cgagtacaag aggctcatgt cgctgggcaa ggcgtatggt      660

gtggaatccc atgtgctgag cccggcagag accaagactc tgtacccgct gatgaatgtg      720

gacgacctct acgggaccct gtatgtgccg cacgacggta ccatggaccc cgctggcacc      780

tgtaccaccc tcgccagggc agcttctgcc cgaggagcac aggtcattga gaactgccca      840

gtgaccggca ttcgtgtgtg gacggatgat tttggggtgc ggcgggtcgc gggtgtggag      900

actcagcatg gttccatcca gacaccctgc gtggtcaact gtgcaggagt gtgggcaagt      960

gctgtgggcc ggatggctgg agtcaaggtc ccgctggtgg ccatgcacca tgcctatgtc     1020

gtcaccgagc gcatcgaggg gattcagaac atgcccaatg tccgtgatca tgatgcctct     1080

gtctacctcc gcctccaagg ggatgccttg tctgtgggtg gctatgaggc caaccccatc     1140

ttttgggagg aggtgtcaga caagtttgcc ttcggcctct ttgacctgga ctgggaggtg     1200

ttcacccagc acattgaagg cgccatcaac agggtccccg tgctggagaa gacaggaatc     1260

aagtccacgg tctgcggccc tgaatccttc acgcccgacc acaagcccct gatgggggag     1320

gcacctgagc tccgagggtt cttcctgggc tgtggcttca acagcgcagg aatgatgctg     1380

ggtggtggct gtgggcagga gctggcccac tggatcatcc atgggcgccc ggagaaggac     1440

atgcatggct atgacatcag gcgcttccat cactcgctca cggaccaccc ccgctggatc     1500

cgagagcgaa gccatgagtc ctacgccaag aactactccg tcgtcttccc ccacgatgag     1560

ccgctggccg ggcgcaacat gaggagagac ccgctgcacg aggaactcct tggacaaggc     1620

tgcgtgttcc aggagcggca tggctgggag cgaccgggat ggtttcatcc ccgaggccca     1680

gctccggtcc tcgagtacga ctactacggg gcttacggga gccgcgcgca cgaggactac     1740

gcctaccgca ggctgctggc agacgagtac accttcgcct tcccgcccca ccacgacacg     1800

atcaagaagg agtgcctggc ctgcagaggg gccgccgctg tgtttgacat gtcctacttc     1860

gggaagttct acctggtggg gctggatgca aggaaggctg ccgactggct cttctccgca     1920

gatgtcagcc gacccccagg gctccaccgt gtacacgt                             1958


<210> 3035
<211> 623
<212> DNA
<213> Homo sapiens

<400> 3035
gagactgatt tgccccatgg gcctaagaca taagctgaac ctctggcctg cagttccaga       60

tccaaggtga ctgagacaaa ctgccagctg ccactggctt atcaggagca cctgggctat      120

cttagtttcc actgctgcag cctgtggcct ggacatttgc ccatggttgt gaggtcccca      180

tgcatgggac ttcttcctcc tgactccagg cttcagttca cccatcaggc cttaaagcat      240

cttcggccct atcttgccct gaactttttg ctgcaaaaac caagggcact gcctcaagct      300

tatcttccca gccactgttt actgctgcta cattgttgcc caagacactt cagaagtgac      360

tgttgttgtc atctcctgcc aagtcctgga aggcaagcca ccaagtccca tgcaccattc      420

ccacagcccg acaaccttcc tgactctacc cactggaatc taaagagtct gcccacttct      480

ggatgtttgt tcaggagatg gacaacatgt ctcccaggct gagagccttc ctctccgaac      540

ccattggaga aaaggatgtc tgctgggtgg atggcatcag ccatgagctc gcgatcaatt      600

tggtcaccaa aggtatcaat aag                                              623


<210> 3036
<211> 3411
<212> DNA
<213> Homo sapiens

<400> 3036
aatcacaggg ctgcggccga gagagaagcc ttattagagc tttctcaacc tgcagccctc       60

atctccgccg gcgagtaggg ccaggtgttg ggagctccca cgtgggacaa gatggtgtct      120

tcggcgcaga tgggcttcaa cctgcaggct ctcctggagc agctcagcca ggatgagttg      180

agcaagttca agtatctgat cacgaccttc tccctggcac acgagctcca gaagatcccc      240

cacaaggaga tggcgagcct ccaggtcttt gaaaagatgc accgaatgga tctgtctgag      300

agagcaaagg atgaagtcag agaagcagct ttgaaatcct ttaataaaag gaagcctcta      360

tcattaggga taacacggaa agaacgacca cctctagacg tggacgaaat gctggagcgc      420

ttcaaaacag aagcacaagc gtttacagaa acgaaaggaa atgtcatctg cctgggtaaa      480

gaagtcttta aaggaaaaaa gccagacaaa gacaataggt gcaggtatat attgaagacg      540

aagttccggg agatgtggaa gagctggcct ggagatagca aagaggtcca ggttatggct      600

gagagataca agatgctgat cccattcagc aaccccaggg tgcttcccgg gcccttctca      660

tacacggtgg tgctgtatgg tcctgcaggc cttgggaaaa ccacgctggc ccagaaacta      720

atgctagact gggcagagga caacctcatc cacaaattca aatatgcgtt ctacctcagc      780

tgcagggagc tcagccgcct gggcccgtgc agttttgcag agctggtctt cagggactgg      840

cctgaattgc aggatgacat tccacacatc ctagcccaag cacggaaaat cttgttcgtg      900

attgacggct ttgatgagct gggagccgca cctggggcgc tgatcgagga catctgcggg      960

gactgggaga agaagaagcc ggtgcccgtc ctcctgggga gtttgctgaa cagggtgatg     1020

ttacccaagg ccgccctgct ggtcaccacg cggcccaggg ccctgaggga cctccggatc     1080

ctggcggagg agccgatcta cataagggtg gagggcttcc tggaggagga caggagggcc     1140

tatttcctga gacactttgg agacgaggac caagccatgc gtgcctttga gctaatgagg     1200

agcaacgcgg ccctgttcca gctgggctcg gcccccgcgg tgtgctggat cgtgtgcacg     1260

actctgaagc tgcagatgga gaagggggag gacccggtcc ccacctgcct cacccgcacg     1320

gggctgttcc tgcgtttcct ctgcagccgg ttcccgcagg gcgcacagct gcggggcgcg     1380

ctgcggacgc tgagcctcct ggccgcgcag ggcctgtggg cgcagacgtc cgtgcttcac     1440

cgagaggatc tggaaaggct cggggtgcag gagtccgacc tccgtctgtt cctggacgga     1500

gacatcctcc gccaggacag agtctccaaa ggctgctact ccttcatcca cctcagcttc     1560

cagcagtttc tcactgccct gttctacacc ctggagaagg aggaggaaga ggatagggac     1620

ggccacacct gggacattgg ggacgtacag aagctgcttt ccggagtaga aagactcagg     1680

aaccccgacc tgatccaagc aggctactac tcctttggcc tcgctaacga gaagagagcc     1740

aaggagttgg aggccacttt tggctgccgg atgtcaccgg acatcaaaca ggaattgctg     1800

cgatgcgaca taagttgtaa gggtggacat tcaacggtga cagacctgca ggagctcctc     1860

ggctgtctgt acgagtctca ggaggaggag ctggtgaagg aggtgatggc tcagttcaaa     1920

gaaatatccc tgcacttaaa tgcagtagac gttgtgccat cttcattctg cgtcaagcac     1980

tgtcgaaacc tgcagaaaat gtcactgcag gtaataaagg agaatctccc ggagaatgtc     2040

actgcgtctg aatcagacgc cgaggttgag agatcccagg atgatcagca catgcttcct     2100

ttctggacgg acctttgttc catatttgga tcaaataagg atctgatggg tctagcaatc     2160

aatgatagct ttctcagtgc ctccctagta aggatcctgt gtgaacaaat agcctctgac     2220

acctgtcatc tccagagagt ggtgttcaaa aacatttccc cagctgatgc tcatcggaac     2280

ctctgcctag ctcttcgagg tcacaagact gtaacgtatc tgacccttca aggcaatgac     2340

caggatgata tgtttcccgc attgtgtgag gtcttgagac atccagaatg taacctgcga     2400

tatctcgggt tggtgtcttg ttccgctacc actcagcagt gggctgatct ctccttggcc     2460

cttgaagtca accagtccct gacgtgcgta aacctctccg acaatgagct tctggatgag     2520

ggtgctaagt tgctgtacac aactttgaga caccccaagt gctttctgca gaggttgtcg     2580

ttggaaaact gtcaccttac agaagccaat tgcaaggacc ttgctgctgt gttggttgtc     2640

agccgggagc tgacacacct gtgcttggcc aagaacccca ttgggaatac aggggtgaag     2700

tttctgtgtg agggcttgag gtaccccgag tgtaaactgc agaccttggt gctttggaac     2760

tgcgacataa ctagcgatgg ctgctgcgat ctcacaaagc ttctccaaga aaaatcaagc     2820

ctgttgtgtt tggatctggg gctgaatcac ataggagtta agggaatgaa gttcctgtgt     2880

gaggctttga ggaaaccact gtgcaacttg agatgtctgt ggttgtgggg atgttccatc     2940

cctccgttca gttgtgaaga cctctgctct gccctcagct gcaaccagag cctcgtcact     3000

ctggacctgg gtcagaatcc cttggggtct agtggagtga agatgctgtt tgaaaccttg     3060

acatgttcca gtggcaccct ccggacactc aggttgaaaa tcgatgactt taatgatgaa     3120

ctcaataagc tgctggaaga aatagaagaa aaaaacccac aactgattat tgatactgag     3180

aaacatcatc cctgggcaga aaggccttct tctcatgact tcatgatctg aatccccccg     3240

agtcattcat tctccatgaa gtcatcgatt ttccaggtgt tggtgaactg cctgtgactc     3300

ctctcctccc cggcccctac ccctcaggga taatgagttc attgctgggc tagatgtttt     3360

agccatgatt ctgcctctgt tttatacctg cacacatcct tatctttgtt a              3411


<210> 3037
<211> 3229
<212> DNA
<213> Homo sapiens

<400> 3037
gcgaagtgaa gggtggccca ggtggggcca ggctgactga atgtatctcc tagctatgga       60

ctaaataata catgggggga aataaacaag tattcatgag ggtgaaaatg tgacccagca      120

ggaaaattac aactattttc aattgacgtt gaataggatg agtcatggaa tttaagtgat      180

ttactgaaga ttatactact ggtagataga agagctaaag aaagatggat actatgatgc      240

tgaatgtgcg gaatctgttt gagcagcttg tgcgccgggt ggagattctc agtgaaggaa      300

atgaagtcca atttatccag ttggcgaagg actttgagga tttccgtaaa aagtggcaga      360

ggactgacca tgagctgggg aaatacaagg atcttttgat gaaagcagag actgagcgaa      420

gtgctctgga tgttaagctg aagcatgcac gtaatcaggt ggatgtagag atcaaacgga      480

gacagagagc tgaggctgac tgcgaaaagc tggaacgaca gattcagctg attcgagaga      540

tgctcatgtg tgacacatct ggcagcattc aactaagcga ggagcaaaaa tcagctctgg      600

cttttctcaa cagaggccaa ccatccagca gcaatgctgg gaacaaaaga ctatcaacca      660

ttgatgaatc tggttccatt ttatcagata tcagctttga caagactgat gaatcactgg      720

attgggactc ttctttggtg aagactttca aactgaagaa gagagaaaag aggcgctcta      780

ctagccgaca gtttgttgat ggtccccctg gacctgtaaa gaaaactcgt tccattggct      840

ctgcagtaga ccaggggaat gaatccatag ttgcaaaaac tacagtgact gttcccaatg      900

atggcgggcc catcgaagct gtgtccacta ttgagactgt gccatattgg accaggagcc      960

gaaggaaaac aggtacttta caaccttgga acagtgactc caccctgaac agcaggcagc     1020

tggagccaag aactgagaca gacagtgtgg gcacgccaca gagtaatgga gggatgcgcc     1080

tgcatgactt tgtttctaag acggttatta aacctgaatc ctgtgttcca tgtggaaagc     1140

ggataaaatt tggcaaatta tctctgaagt gtcgagactg tcgtgtggtc tctcatccag     1200

aatgtcggga ccgctgtccc cttccctgca ttcctaccct gataggaaca cctgtcaaga     1260

ttggagaggg aatgctggca gactttgtgt cccagacttc tccaatgatc ccctccattg     1320

ttgtgcattg tgtaaatgag attgagcaaa gaggtctgac tgagacaggc ctgtatagga     1380

tctctggctg tgaccgcaca gtaaaagagc tgaaagagaa attcctcaga gtgaaaactg     1440

tacccctcct cagcaaagtg gatgatatcc atgctatctg tagccttcta aaagactttc     1500

ttcgaaacct caaagaacct cttctgacct ttcgccttaa cagagccttt atggaagcag     1560

cagaaatcac agatgaagac aacagcatag ctgccatgta ccaagctgtt ggtgaactgc     1620

cccaggccaa cagggacaca ttagctttcc tcatgattca cttgcagaga gtggctcaga     1680

gtccacatac taaaatggat gttgccaatc tggctaaagt ctttggccct acaatagtgg     1740

cccatgctgt gcccaatcca gacccagtga caatgttaca ggacatcaag cgtcaaccca     1800

aggtggttga gcgcctgctt tccttgcctc tggagtattg gagtcagttc atgatggtgg     1860

agcaagagaa cattgacccc ctacatgtca ttgaaaactc aaatgccttt tcaacaccac     1920

agacaccaga tattaaagtg agtttactgg gacctgtgac cactcctgaa catcagcttc     1980

tcaagactcc ttcatctagt tccctgtcac agagagtccg ttccaccctc accaagaaca     2040

ctcctagatt tgggagcaaa agcaagtctg ccactaacct aggacgacaa ggcaactttt     2100

ttgcttctcc aatgctcaag tgaagtcaca tctgcctgtt acttcccagc attgactgac     2160

tataagaaag gacacatctg tactctgctc tgcagcctcc tgtactcatt actactttta     2220

gcattctcca ggcttttact caagtttaat tgtgcatgag ggttttatta aaactatata     2280

tatctcccct tccttctcct caagtcacat aatatcagca ctttgtgctg gtcattgttg     2340

ggagctttta gatgagacat ctttccaggg gtagaagggt tagtatggaa ttggttgtga     2400

ttctttttgg ggaagggggt tattgttcct ttggcttaaa gccaaatgct gctcatagaa     2460

tgatctttct ctagtttcat ttagaactga tttccgtgag acaatgacag aaaccctacc     2520

tatctgataa gattagcttg tctcagggtg ggaagtggga gggcagggca aagaaaggat     2580

tagaccagag gatttaggat gcctccttct aagaaccaga agttctcatt ccccattatg     2640

aactgagcta taatatggag ctttcataaa aatgggatgc attgaggaca gaactagtga     2700

tgggagtatg cgtagctttg atttggatga ttaggtcttt aatagtgttg agtggcacaa     2760

ccttgtaaat gtgaaagtac aactcgtatt tatctctgat gtgctgctgg ctgaactttg     2820

ggttcatttg gggtcaaagc cagtttttct tttaaaattg aattcattct gatgcttggc     2880

ccccataccc ccaaccttgt ccagtggagc ccaacttcta aaggtcaata tatcatcctt     2940

tggcatccca actaacaata aagagtaggc tataagggaa gattgtcaat attttgtggt     3000

aagaaaagct acagtcattt tttctttgca ctttggatgc tgaaattttt cccatggaac     3060

atagccacat ctagatagat gtgagctttt tcttctgtta aaattattct taatgtctgt     3120

aaaaacgatt ttcttctgta gaatgtttga cttcgtattg acccttatct gtaaaacacc     3180

tatttgggat aatatttgga aaaaaagtaa atagcttttt caaaatgaa                 3229


<210> 3038
<211> 554
<212> DNA
<213> Homo sapiens

<400> 3038
attgcctctc accccccgga ggggttattt tgggggtggt tggaggcggt ggcggcggcg       60

gcgaggaggg gaatttcctt gtgcctccat tcccgggagg ggggagcggc gttggaggcc      120

accgtttcca ggtgtgggaa taagtatctt tggaagacca ggcactttat gcagtattga      180

gctcaggagg cagtgagtgt taaggaatgg gtgtaaaaca tcaacaacag caacttgtga      240

ttggcggtga ccggatattc agttgcacat ccccacatca atgcactgcc aatgtgggat      300

tacagctaag tattacgttt taaaggttat atcctgtgtt gtgacctcat ggtttaagtg      360

ggaataaaga tgagtataag cagtgatgag gtcaacttct tggtatatag atacttgcaa      420

gagtcaggat tttctcattc agcatttacc tttggtatag aaagccatat cagtcagtcc      480

aatataaatg gtgccctcgt cccacccgct gcattgattt ctatcatcca gaaaggtcta      540

cagtatgtag aagc                                                        554


<210> 3039
<211> 666
<212> DNA
<213> Homo sapiens

<400> 3039
gggaacggac gctcagggcc ccggtggcct gggtgcacgc gcccgccgtg caagggatgc       60

tcccggccgc ccccggttcc gcggctccat ctgggatgcg gcgaggaggg cagccgagct      120

gtccgcaaac aacgggcctt tagttttcag gtggcgaaac tgactggtct ggttagagcg      180

cgtccaagcc aagccgcagt gctgtttgga tttttaaatt tctccttctg agtgagaaaa      240

tagcaatcga gatggaacca tccgcacaac agctccagct ggcagcatca cttcccgcca      300

atttatccaa cttctgccaa ggctctgaaa tgccaacaac gtcgaggcct gcacttgatg      360

tcaagggtgg cacctcacct gcgaaggagg atgccaacca agagatgagc tccgtggcct      420

actccaacct tgcggtgaaa gatcgcaaag cagtggccat tctgcactac cctggggtag      480

cctcaaatgg aaccaaggcc agtggggctc ccactagttc ctcgggatct ccaataggct      540

ctcctacaac cacccctccc actaaacccc catccttcaa cctgcacccc gcccctcact      600

tgctggctag tatgcacctg cagaaactta atagccagta tcaggggatg gctgctgcca      660

ctccag                                                                 666


<210> 3040
<211> 8036
<212> DNA
<213> Homo sapiens

<400> 3040
aaaagggcgg tggggcgggg ggcggggcag ggagagggag agaaatccag cagacatcta       60

gctctgcctt tctttcccag ccacagccag ggtagggctg ataaggcgct gatgcgttga      120

tggcagcctt gcagagctag acctgcactt aacttgcagc tgcctcccga gcctccaaga      180

tgtccacgcc ctgggtgaca ggcggcaggg cgctgccccg tgctcccccg gctctgctcg      240

acagcagcac gcagtgagag cctcgccgcc gccgaggagc aactcatgta acggcacagc      300

caacaagatg aacggagctt tggatcactc agaccaacca gacccagatg ccattaagat      360

gtttgtcgga cagatccccc ggtcatggtc ggaaaaggag ctgaaagaac tttttgagcc      420

ttacggagcc gtctaccaga tcaacgtcct ccgggaccgg agtcagaacc ctccgcagag      480

taaaggttgt tgtttcgtaa cattttatac aagaaaagct gcacttgagg cccagaatgc      540

actgcacaat attaaaactt tacctgggat gcatcatccc attcagatga aacctgcaga      600

tagtgaaaag tccaacgctg tggaagacag aaaattgttc ataggaatgg tatcgaagaa      660

atgtaatgag aacgacatca gggtgatgtt ctctccattt ggccagatag aagaatgccg      720

gatcctccgg ggacctgatg ggctgagtcg aggctgtgcg tttgtcacat tttctacaag      780

ggcaatggca cagaatgcaa tcaaagccat gcatcagtct cagaccatgg agggctgctc      840

ttcacctatc gtggtgaagt ttgctgacac tcagaaggac aaagagcaaa ggcgcctcca      900

gcagcagctc gctcagcaga tgcagcagct caacactgcc acctggggga acctgacagg      960

gctgggcgga ctgaccccac agtatctggc gctcctgcag caggccacct cctccagcaa     1020

cctgggtgcg ttcagcggca ttcaacaaat ggcaggcatg aatgctttac agttgcagaa     1080

cctggcgacg ctggctgctg ctgcagctgc ggcccagacc tcagccacca gcaccaatgc     1140

aaaccctctc tctaccacga gcagcgccct gggagccctc acgagtcccg tggctgcttc     1200

aacccccaac tccactgctg gtgcagccat gaactccttg acctctctcg ggactctgca     1260

aggactggct ggagccactg ttggactgaa taatattaat gcactagcag ttgctcaaat     1320

gctctcaggt atggcggctc tgaatggagg acttggcgcc acaggcttga cgaatggcac     1380

ggctggcacc atggacgccc tcacccaggc ctactcagga attcaacagt acgcagccgc     1440

cgcgctgccc actctgtaca gccagagcct gctgcagcag cagagcgctg caggcagcca     1500

gaaggaaggt ccagaggggg caaacctctt tatttaccac cttccacagg aatttggaga     1560

ccaggacatt ctgcagatgt tcatgccttt tggaaatgtt atctctgcta aagtcttcat     1620

tgacaaacag accaatctga gcaagtgctt tggttttgtt agctacgaca atccagtctc     1680

tgcacaagct gctatccaag ctatgaatgg ctttcagatc ggcatgaaac gcttgaaggt     1740

gcagctgaag cgttccaaaa acgacagcaa accttactga tcctaacccc agaggctccc     1800

tgctctcatt ttagctttct taggacatct tcatgcccgt tagttcatcg tttgcctagc     1860

atgtccctgt ggcgtctcaa aaaaaagttt catcgtcccg tcattgtttc tgatgtcttt     1920

ctgacctcac atcatatttg gttctcctac tgacctttga tctagtttga cctttgaaat     1980

ttgcatgtga cctcatctag ctatgaattc tgggaagtca atgtgaaaaa cattgctgca     2040

ttcatgcaag actgaaattt attattagac aaattcatta tagaaaaaac ctgtggcaaa     2100

aacgtttctt tcttattttt tttcttttcc taaaacagac ttgaaagtat tatacaggga     2160

ttggcattct tcccggtcac tggtaacaat agcaatatgt gtccagggac acagaatgtt     2220

ggtttctaac agactacttc caaaaacagt ttgagaaaaa aactgtctga ttttaagtct     2280

ctagaggtct gtaatagttt ttacattttt caggcagtgt aaagtttttt gataaggcca     2340

ttttaggtgg ctcactttct cattaagata tatatataga accacttttt gtagattagt     2400

ataagaaaaa tatttaccct gttttggggc aaatgctacc tatttgtgtc accttttgct     2460

gaactcacag ttagacaatc catggtttaa tgcacatgaa attacctata ttttatactg     2520

tttcaatgta caggagaaag gttactgtaa actgtgttat gttggtgctt ctgtgaatta     2580

agttgtggtt tcatcatgag tcttaatgtt ctttgttgat aagacaagtt tagaattggt     2640

ttacttaata caaaaaaaaa aaaaagaatt tcaaaaaaaa aagttgtttg cttaaaaaaa     2700

atttcatgtg agggaaaaaa aaaaaaccta ttccagaata agttttgtgt tggcttgtga     2760

agcattgatg tcattttttt taattgtgga ctatttagat gtgtttgtgt tcagcaaaat     2820

gtgatgtttt tttcttttaa agaaaaaaag tgaaaatata tagtgccaaa ttccaaaggt     2880

acttccttcc tagagcttca gtgtgtttct tgtgagaagt aatttgataa catgggtatt     2940

ttattatgtg ttttgtataa atccctaata tttaaaaaaa aaaacaaaac aaaaaaaggt     3000

tacaaagttt gttaacttgc tatcctgtgg tcttgttgcc tgaaattgtt attgtttgtt     3060

atttctctct gatgtttttt gtaagacatt gtataagtgc ccatgtccca cttttttaac     3120

cactccgcac atcagtgctg tgaaggcaac ctcaccatgt attttcttca taatctatgg     3180

aaacctctaa ggtgagaaag ttttgaactt ttaacccttt ctacccagag ctatctggaa     3240

tgttgatgac tttttatact gtcatgattt gagtttgttt tggggtgttt ccaatttgga     3300

tttttttccc tgcatctatc ctctaagttg tttcggtttg actactttgt tctttggtta     3360

agatccaaaa gaaaacagaa aacaattcca cgaggccaat ctaaagggaa aaaatcctac     3420

actactttta ctacttttga ttatttctca tttttgggaa aagaattcct aatgtgctac     3480

tagaattcct tcttcagttt taacgagtaa ttggataaac cctgagggaa aacggaggta     3540

gattcagcac ctaacaatcc tgtatgcttt tgagatcacg tttagtgcta tgtcctagtc     3600

tagaatattt tcatatacct tgcagtaaaa cgactttgtg gcaggacagt ctcttgaggg     3660

gttttgtttc tgtttcctaa atactcctaa ataatatttc taatcagcca ttatgctggg     3720

gcatctctga tcccagtagg tacctctgaa tataccaggt gtctggagtt agaagcccat     3780

agccctttcc cagccttttt ggttttttta attgaacaca tttcatctaa gtaaagctca     3840

gttctttatc acaatttact gaccaaatac ctagcaccag ttcctgctgc cactttttaa     3900

agtgccatat gactttctac gaacaggtac cttgctgtct tgacaaatcc taatgtcacg     3960

cctacagccc caacacaagc tccagtcttc ctcttcggca tgccctggaa gcttcttggc     4020

ctcagctccc cttccccgct cagcaccctg ttaggatcag tgtgtgtgga tgggatagcc     4080

ctgggatgga aaggactagc ctctactgat gcaaaaaaac aaaaagcaac acaaacgttt     4140

ccttcttata gcacatgcac ttccttacaa tgacatgatt tgtattatcc tcacatgtgt     4200

ttactactgc tggggccttc cttcatcctc tgagggctat tttgtacttt ctgcagcaat     4260

cagcttaata acaacactta ttgcacctgt ctctctctga gaacacggtg tgtctcgaca     4320

cgtaccacgt acgtggaaac acaagagccc accacttgaa tttctaagac catttcattc     4380

tgaaacttct tatcaattac ctaaatctca acgaaaaaca atttactgaa gccgactccc     4440

ctccccatct ccctctcaac ctcaacccac ctgcatgcat ctcccccaga ggaaacactg     4500

agggtagggg acaggaggct caggacgcgc cctctgaatc gagtgtttct tcttcacaag     4560

tcaccaagag aggacatgag ggggaaagtc ctttttgccc ttctccaaaa aataaccttc     4620

cacagagaca aactgtcctt ctatccactt ttatctttta ataaatatca aaaggaaaaa     4680

gctgcaaggg tgcaaagggc ctgtgccaga agaaaacaca cacagggaaa ccgctttttt     4740

taatcaattg tagagaatag tcatttttaa tctaaattag agaattgtga tacaatggca     4800

gtcctcaaag gcgtaacgag ttcatctttc tttcaccata ggggttatag ttggcttgtg     4860

ctactctgga atcattttac tgtttgtttt tattatctta agtgctaatt aaaaaaaaaa     4920

taaaatttta aaaaaacctg tagtttcatt acctttttga ataatgtcat acaaaaaatg     4980

tatttgtttt tttgtgctgt gagaattgat gtttgtagat taataatcat tttgtttaga     5040

attacaaaat agtttttaaa tattgtctga gaaaagccaa agttaatgca acctagtgga     5100

aactgtaaga ccatttgagt attgtttgtt ttattgatgc atttggattt tgttgtttga     5160

tggaatttga gccaaaaaaa aaatacgcag gctttcctat ttctacaact gattgtactt     5220

atgcattttg taccagtgga actttttata ctggagatta aaaaaaaaat ggaaattttt     5280

gtggcttgct ctggtgggcc cctgacaatg actgatttca agtttgattt cgggttgatt     5340

gattgattga ttgatagaaa gaaagttgct tttcttttga gaattaaaaa ctttggcttg     5400

atttcttttt tccctttgct tatatctagc attagaattt tgtcttaaaa taacagcggt     5460

aagtttcact ttttattctg tattgtgcag ttacacaata aggtaattag atttagaagt     5520

actcagtcac tttaagtgga taaatgtatt agttaaaact ttagggtttg cttttttgct     5580

gtttagatca aagttttttc tgattcttct gtcctcattg tgaacataac cgtgtagttg     5640

aaacagtcaa acttattttt gtaatgtatg ttattgtgtg atgcagtttt ttgcttctgt     5700

ctccaatatt aaaccatttt cctaatactt gtttctctct ctgcgtgttg tattgttggt     5760

agtcattata tgttggtgat acatctgcac acctcactgt ttcacgtatc tgtttttttc     5820

tctatgttgt gtaaaaagat acagtcgatt ccacttaagt gaatatctga tttggggaag     5880

aggaaactgc acagcagcca cctttgattt atgtacaacc gcccacttga actcctgctt     5940

ccaagattta tacacttttt tcctacagtt cacctcagta actgcctttg gggttggatt     6000

tgccaaggtg ttttacggtc ttttgaccac acaggttaat ttccccttct ctcccctccc     6060

tcatgagtct atccacgcag ttcttaacat acattccaaa ctgctgcggg gtttcctctc     6120

cacacccacg aggccaaacc cgcatcatta cagtccaact cttcttagac actaatcact     6180

ttctaaaaga agtgagttct ccagggaaga aaaatcaact tagccagtga aaagggttaa     6240

acttaagtct attatttgtt gccctcaatc aaaagatatg tatagaaaag tcatttaaat     6300

tatttatttc tacaagctaa ttgaatccag gagcagcttt aattattaac actaacggaa     6360

gagaaaagaa gtatttccaa gggctcaaat ggaagctgta ctcagtccgg tggaggcagg     6420

gggaggtaaa gtttctcaca ctcaagtcgt cttcatagtt tactgtcctt ttccaaacaa     6480

aagctaataa cgccatacgc atccacacac tccctcctgg atgaacctaa gtctcgtccc     6540

cactgtcacc ccaaggccag ttatcaaaaa ctgttccttc tctgccctca aagactgaag     6600

ccgcaggccc tgttctgcct ctgctcagga atctgattgc tcttaaagtg ctcttacaag     6660

attccgtcga tgtttgctcc ctctgtctta tctctccttc cagtattttc agacgcacaa     6720

gctctgactc aggccaccca gcacctggca gccttcctct gcgtgccagt gaaatctctc     6780

ccagtaggtg ctcaggctct tcaccctctc gttgcagcag cccctctggc ccgagattgt     6840

attttctagt ctgctcaaga acagaggggc ctggcgaggt ggaggaaggg aggctccctc     6900

cccggggctg gccgcctcag tgatggtgat gccaccagct ccagcctgca cggatggagc     6960

tcacttccta ccatcacttc tgctttcagt ctcctcatag ccttcggcag tctcctctga     7020

aaacacactg cctacgttag tgggaaagga tggctaaggg tgtgatttct ttttattagg     7080

gaggtgggag ggggatgttg ggaggcatgg ggggtgatta aattatcatt tccaaggtgc     7140

aagtgtttat ttttcaaatc tataagtaca tagttccacc attttggcac aagacaaaat     7200

actcatgcta agcaaaggaa gagaaagaca aagccagttt ttgttgcttt tctaaagcaa     7260

caaataattc tccaaagaag gggatgaaaa tgctagttcc tttaagcact tactgactgt     7320

aaagttggtc cctgcttaaa ttcataccca tagttttgag tcggtatgac accactgcag     7380

tgtgagcaag gtgaatccgt gtgccatgca tggaccacct tgggataccg cagcaccatc     7440

aacatccgcc ttgctgatgg aagccacaca cgctgcccag cccacagcag tcgcacgcag     7500

ccgatgggct cggactctta gctggcaggc taggacacac agtgaacatt aatgtactgt     7560

gaatcgttcc tgataagtga ataaaacatt gtgaccaaac aatcagctta ttcacttatc     7620

aggaatcgac tgttctgcta atttgctgtt gttgtttttc atctctgttg tagttcacta     7680

tttttgctgt gttctgtttt ctcctctcat gcttgggcaa atcactggga atattatctt     7740

catgtgacca tgaaacgttt ctattgagtg aaaatgatat cttaacaaaa tctatgcact     7800

tgctatcagg aacacaatac tggatgtgtc ttatatatat tgaactatat agtactcgat     7860

ttcttaaata aagcttaaga aaggactctg ttgtgtgtaa agttaatgtg attatttttc     7920

aaagcagtgt ttctaagggg tatttttgtt cttttaagtc ttgagtgata caggatattt     7980

ttcattaaaa ttatatcact ggctttatga cttaatattc aataaattga ctttgg         8036


<210> 3041
<211> 568
<212> DNA
<213> Homo sapiens

<400> 3041
agatgccgcc gaagcgtcta gcgggaaggg cgccggcgcg gctggagggt ctcagtacag       60

ggtctctgag cctgttgccc aatctggagt gcgatggtgc agtcacatct cactgcagcc      120

ttgagctcct ggactcaagt gattctccac ctcagccttc ctcatagcta ggactacagc      180

tttgtaggca gccaatccca gagaagcaga cgggatggct agttcagccc gggagcacct      240

gctttttgtg aggcgtcgaa atccccagat gcggtacaca ttgagcccag agaacctcca      300

gagccttgcc gcccagagct ccatgccaga gaacatgacc ctgcagcggg ccaacagcga      360

caccgacctg gtgacttctg agagccgctc cagcttaact gccagcatgt acgagtacac      420

gctggggcaa gcccagaacc tcattatctt ctgggacatt aaagaggagg tggaccccag      480

tgattggatt ggactttatc atatagatga gaattctcca gccaacttct gggattctaa      540

gaacaggggt gtgactggaa cacaaaaa                                         568


<210> 3042
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 3042
gggagattac ggggcgggga cgagctgtcg cgctggttgc tcgtgcagga gcgggacccg       60

gaacagaccg ccgtgagaga ggaggggcgc cggccgggat tcgcggcccg gagctcggga      120

ccggttgctt cattccagcc tcgcagtcac ctctgtgccc tgctggttgt cttcccagcg      180

ctgctgtagt tgccttccat ggatctatag gagagcaagt cctccaggag aagaagtcct      240

caccagtgaa cggagacctc tctgaactaa ggataccatg gccacgtcag ccccactacg      300

gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac      360

cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg      420

gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt      480

gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca      540

gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa      600

gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg      660

ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa      720

aatcctgaac cacctgagta ccctaaggag ggacagagac aaaattcagg gcttccaggc      780

aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat      840

tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga      900

acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg      960

cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca     1020

gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa     1080

gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga     1140

taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt     1200

ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct     1260

gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc     1320

ccagcagttt gactgtgagc ctggggtgct gggcagcaag ggcttcacct ggggcaaggt     1380

ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga     1440

ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga     1500

cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga     1560

ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag     1620

gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc     1680

cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag     1740

agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca     1800

ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct     1860

caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc     1920

caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc     1980

ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct ccccattgct     2040

gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt     2100

ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct     2160

ttcctttttg accacgacct tggccccagc tctgcactct ctggaataag ggcccgatgc     2220

agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc     2280

attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc     2340

ttccctggca ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa     2400

tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag     2460

cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc     2520

atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat     2580

ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga     2640

ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc     2700

aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc     2760

aggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact     2820

ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc     2880

ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa     2940

cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa     3000

ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa     3060

gttttaagtc ctccaccctg ttctaagaga ctgttccaac ggctctgggc ctcagtggtc     3120

acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca     3180

cacgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta     3240

tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat     3300

aaagacttgt tgaatgaa                                                   3318


<210> 3043
<211> 568
<212> DNA
<213> Homo sapiens

<400> 3043
gatgcattta gtgttttcat agataggttg acgatgtgtc acactgtgta agggaatcgc       60

atggagatgg gcattccgaa ctgttaatgg ggacatggga ctccagttgt ctctgatcac      120

ttgtgtggat tttcctggcg tagaacgaca gaagccgcta gtaagtcgcc aagacctaca      180

gcaggaattc tgcaccaaag ggcataaaat cttgttattt taatttgcat ctgggagaat      240

gtctgagcaa ggagacctga atcaggcaat agcagaggaa ggagggactg agcaggagac      300

ggccactcca gagaacggca ttgttaaatc agaaagtctg gatgaagagg agaaactgga      360

actgcagagg cggctggagg ctcagaatca agaaagaaga aaatccaagt caggagcagg      420

aaaaggtaaa ctgactcgca gccttgctgt ctgtgaggaa tcttctgcca gaccaggagg      480

tgaaagtctt caggatcaga ctctctgaaa actgcaaatg gaaaggaatt caaaagaatt      540

tagattaaaa gttaaataaa aagtaggc                                         568


<210> 3044
<211> 2031
<212> DNA
<213> Homo sapiens

<400> 3044
agccagccca ggcagggcgc tgaatcggca caaaccagtc tcacttcttg taccgcagtg       60

gggaggttgg agagaatttt ttcccatgaa agggcatacg ttgcccgtcc ccttccccga      120

agaacgcact aggaatactg ttcctgcgtt tgcatgagct gtggcaccag caccgactca      180

gccttccggg cctccctcat gcacggagcc tctcactagg tctcacccgc ggctgcgttg      240

gtgccgtccg gcacggtcac gtgggcgaga aaatggcggc ccccagaccg cactgcgggc      300

gtcgcggcag gtgaagcggt ggtggcagag gcgcctgcgg ttactggccg ggccgacggg      360

tcctgagtct ccagagctcg gttcttacat ccccgcgtcc ccaggtttag cctgagcagg      420

gttgtggaag gccgggaccc attgacagca cgatggtgac ggagcaggag gtggatgcca      480

tcgggcagac gctggtggac cccaagcagc ccctgcaggc ccgcttccgg gcgctgttca      540

cgctgcgtgg gctcggcggc ccaggcgcca ttgcatggat cagccaggcc ttcgatgacg      600

attccgccct gctcaagcac gagctggcct actgcctggg ccagatgcag gatgcccgcg      660

ccatccccat gctggtggac gtgctgcaag acacccgtca ggagcccatg gtgcgccatg      720

aggcagggga ggccctgggg gccatcgggg acccggaagt tctggagatc ctgaagcagt      780

attcctcgga ccccgtcatc gaggtggccg agacctgcca gctggccgtg cgcaggctgg      840

agtggctgca gcagcacggc ggggagccgg cggcgggacc ctacctctcc gtggaccctg      900

ccccgccggc tgaggagcgt gacgtggggc gcctgcggga ggcgctgctg gatgagtccc      960

ggccgctctt cgagcgatac cgcgccatgt tcgccctgcg caacgcggga ggcgaggagg     1020

ccgccctggc gctggccgag ggtctgcact gtgggagcgc cctcttccgc cacgaggtcg     1080

gctacgtcct gggacagctg cagcacgagg cggcggtgcc ccagctggcg gccgccctgg     1140

cccgatgcac cgagaacccc atggtgcggc acgagtgcgc ggaggccctg ggcgccattg     1200

cccggcccgc ctgcctggcc gcgctgcagg ctcacgcgga cgacccagag cgcgtggtgc     1260

gtgagagctg cgaggtggct ctggacatgt atgagcacga gaccgggcgg gccttccagt     1320

acgcggacgg cctggagcag ctgcgcgggg ccccctccta gggccccacc ctcacccgga     1380

gctcccggag gactcttgag ggccgctcct cccccgcaga gctttggcgt ctaaaccggg     1440

tgtgtgtaaa tcggtgtcat cgcttgtgtc ttgctgggcg catggttgct gtccccctcc     1500

tccgtctggg accgaggagc tgccgttgtg ctgtgactcc ctgagtcccc tgactgctcc     1560

tcggggcctg gcgcagggct gtagcgtgga agtttccagg cttggggtgg gactctgcgg     1620

gaggctctgg gatgcccggc tcaggacagg ggaggattgc gagggaagcc aggggaggat     1680

cgcgagggaa gccaggggag gatcgcgagg gaagccaggg gaggatcgcg agggaagcca     1740

ggggaggatc gcgagggaag ccaagggagg atcgcgaggg gagccagggg aggatcgcga     1800

gggaagccag gggcagagct ggggctctgg gaagaggctg acgttatggt ggcttcagct     1860

tcactaggaa tgggacacag ggtctggggg cctctgactc ccccaccccg aggcctgggt     1920

agggacaggg tggtggtccc tgagtgggtc aggtagggca caggggccag ggagggacaa     1980

gcagacctca gagcgctgcc cagatggaat attaaattat ttttgccaag c              2031


<210> 3045
<211> 3104
<212> DNA
<213> Homo sapiens

<400> 3045
tccgacattg gagatttcta atccctttcc tttatcatgt gtctgtattg tgtaccctcc       60

ttcatttccg aaattcaaac aaacaaaaaa agccagcgtc taaaaggcca gatggccgat      120

agcggacccc tcctcctgcc cccaatttca agcttaaagt agccagcgtg gattctgatt      180

tcaaaataga agatgagttg tcacactccc tggaccattt cttcagcaca acacagtttt      240

agggggagcc tcaggatata cgtgcacatg tccttgggcc aggatgtccg tactaagccc      300

tggggatcta aaaccaaagc gaggctcccc acacagaggc agccttgacc gcacagatgc      360

ctccaccgat ctggccatga ggtcctggcc ctcggagctg ggctcccgga cttgctcaac      420

ttcagccacc actacagccc cttccaactc cacccccatc gcccggcacc caggccgcac      480

caaaggctat aactcagatg acaacctctg tgagccatcc ctggagtttg aggtccccaa      540

ccacaggcag tacgtgtcgc ggccaagtag cttagagagc agtagaaaca catccagcaa      600

cagctcacct cttaacctaa aaggctcctc cgagcagctc catggccggt ctgagagctt      660

cagcagcgaa gacctgatcc ccagcaggga cctggccact ttgccccggg aagccagcac      720

accgggacgc aacgccctcg gccgccacga gtaccccttg cctcggaacg ggcctctccc      780

acaggagggt gcccagaaga ggggcacagc ccctccctac gtcggagtgc ggccctgctc      840

ggcctccccc agcagtgaga tggtcacctt ggaggagttc ctggaggaga gcaaccgcag      900

ctcccccacc catgacactc ccagttgccg ggatgacctg ctgagtgact acttccgaaa      960

ggccagcgat cccccagcca tcggaggcca accaggacca cctgccaaga aagaaggggc     1020

caagatgccc accaactttg tggcccccac cgtcaaaatg gccgccccca cctcggaggg     1080

gaggccgctg aagcccgggc agtacgtaaa gccaaacttc agactgactg aggccgaggc     1140

cccacccagc gtggccccga gacaggccca gcctccccag agcctgtctc tgggcagacc     1200

ccggcaggct cctgaggcct tagggggcag agagacaggc agccacaccc tgcaaagccc     1260

cgcacccccc agctcccata gcctggcccg ggagcggacc ccacttgtgg gaaaggctgg     1320

cagctcctgt cagggcccag gtccccgcag ccggccgctg gacacgaggc gcttctccct     1380

ggctccccca aaggaggaga ggctggcccc cctgcatcag tctgccacag cccccgccat     1440

tgccactgca ggtgctggtg ctgctgctgc tggcagtggc agcaactccc agctcctgca     1500

cttctcacct gctgcagccc cggctgccag gaccaagccc aaggcgcccc cacgctcagg     1560

ggaggtggcc accatcaccc ctgtccgggc agggctcagc ctctcagagg gagacggggt     1620

cccggggcag ggctgcagtg aggggcttcc ggccaagagc ccaggtcggt ctcccgattt     1680

ggctccccac ctcggccggg ccctggagga ctgcagtcga gggagcgtct caaagagcag     1740

tccggcctcc ccggagcccg gcggggatcc gcagaccgtg tggtatgagt acggctgtgt     1800

gtgactgtct cgtggttgag ctcgcaaacc tgaaaactac tgacgcgcct tccgactctc     1860

acggcctttt ctcttgcttg cctgcggtgc caggagaggg tttggaatga ggaaaggggt     1920

tcccacgcat ttctgctgtt tgttctgtga atggaaacac tgtgccaagc cccaagagga     1980

ttacgcttcc aggtgtgtaa cgtgttttct gtgtctgccg cttccagcag ctgatatctt     2040

tggaacaaat aatccacgtc agcatgggga ccaattagga tgcaatgaca aactgacttc     2100

ccccaaagca gacactactc cagtatgtcc cagtagaaca ctcatttgca atgtgttgag     2160

ctccgttaag cacacacaca ctcacacaac aggcttacga ggctcaggcc tggcgggtca     2220

gaaagcccac tccctctccc aaggccactg gatcccagga gaagcccaga ctggcgatac     2280

tacaaaggtc tccagggcct ggcagacccc agagtcaggc ctgctgttaa aaagtgagag     2340

tgctgctgtt ccattcctgg ggtcccaagc acttcccttt accccaggac ccagggcagc     2400

ctgcagggca gctggcggtg gccttggcca tttgccccca gcctccagct ggctcctgag     2460

ctctgcacca gggggtttgg ggaccacaca ggcacctgcc ttcctagatt tccctggctc     2520

acttttctgc aaacactgga tctgccaggc ctggggattg gggggcagga aagaggcccc     2580

catccagccc cctccaggcc agtgtgcaca gtgcaccgag gggtcatccg cacagagcga     2640

ggtgcaagct cgatgtgtaa cctggctgcg gcacccgaca tccccggtct cggggtgttg     2700

atttatttct gaataacttt ttgggtatag aaaccaattt tttttaatat atgacatgta     2760

tatgtacaca ctcatgtgaa atatgtatac tttgggggga tctatttatg ttccagtggg     2820

agtcactctc ttctgtcggg aatcttatct gctgctttgt gtctttggtc agattcctga     2880

caatttagtt tcctgttgta aaggtgcttt tcctggggtg aactaaacct attgattttt     2940

tttttttaag attttttttt ccttttgatt taatatactg agaaagaaat gggagacttt     3000

tgaatgttaa caagatccat tttaggagtg tttggggttg tgtattaaat agccattcat     3060

tctggaactc aaggacagga ctgtaataaa atggaatgga accg                      3104


<210> 3046
<211> 1135
<212> DNA
<213> Homo sapiens

<400> 3046
gcactaggct gaccgcaacc ggctgaccac acacagtcct cactcccctg gccctggtgg       60

gcggcaggca ccatggcgca gacagtgccg ccctgcgagc tgccctgcaa agagtacgac      120

gtggcccgta acacgggcgc ctacacgtcc tccggcctgg ccaccgccag cttccgcacc      180

tccaagtacc tgctggagga gtggttccag aactgctatg ctcgctacca ccaggccttc      240

gccgaccgcg accagtcgga gcggcagcgg cacgagagcc agcagctggc cacagagacc      300

caggcgctgg cgcagcgcac gcagcaagac tccacgcgca cagtgggcga gcgactgcag      360

gacacgcaca gctggaagtc ggagctgcag cgtgagatgg aggcgctggc tgcggagacc      420

aacttgctcc tggcccagaa gcaacggctg gagcgcgccc tggacgccac agaggtgccc      480

ttctccatca ccactgacaa cctgcagtgc cgtgagcgcc gcgagcaccc caacctcgtg      540

cgcgaccatg tggaaacgga gctgctgaag gcccttcccc ctgcactctc tcagtgcctc      600

aagaactcct gcagctcccg caaactctct gcccgcaaca agggcacctg ccaactgatg      660

gagacactga cagtgcacgg agaggcaaac ccagggatag aggggcgcag gacccgggcc      720

ctggcacaca aggaagtacc cagtggttga ggcaaagacc ccaatcacag agaaaaggct      780

tgttcctaca cacagcaaat taaactggcc aggcaataag aagaaacaca gggtccttct      840

cctgttcttg gtgtgaagat ggcctttccc agcacagagc cctgaggggc agcctgggcg      900

ggcatctggg cccccagagt ttgggtcctc aggggctgtc cagaggccaa gggcaggcca      960

acgttcccag gtgcactgag tgagcagcag cgatgactcc tgaagcctgg ggcgtgggaa     1020

ctgccgctga gggaccttcc cagcagccca cagaaggccc tggaggaaaa caccccactt     1080

acaacgcacc aaggagaatg cccaaaagcc caagataaac ccagtgagag agcag          1135


<210> 3047
<211> 526
<212> DNA
<213> Homo sapiens

<400> 3047
aaacacagtg ctcacctacc gagcgcagcc aggagcgcag cgccagacaa ttacaggagc       60

tgttttggat atggccgggc agcccagcga tgctcagcga atcccacaac tacaaccaca      120

accgtaccac acatttagcc tgcaaaagca gagaaaggaa aagaaaaccg tgcagggaag      180

ccggaaacga gggacttaag ggtctcctct ctaggggaaa atggcgaacg actcccctgc      240

aaaaagtctg gtggacatcg acctctcctc cctgcgggat cctgctggga tttttgagct      300

ggtggaagtg gttggaaatg gcacctatgg acaagtctat aagggtcgac atgttaaaac      360

gggtcagttg gcagccatca aagttatgga tgtcactgag gatgaagagg aagaaatcaa      420

actggagata aatatgctaa agaaatactc tcatcacaga aacattgcaa catattatgg      480

tgctttcatc aaaaagagcc ctccaggaca tgatgaccaa ctctgg                     526


<210> 3048
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3048
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cgaagtcctc      180

accagtgaac ggagacctct ctgaactaag gataccatgg ccacgtcagc cccactacgg      240

agcctggaag aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc      300

attgactgtg gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg      360

agccgccccg tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg      420

tggcaactgg ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag      480

ccgggagagg tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag      540

ctgcactact actgtgagga cgacgggaag ctgctgtgcg tg                         582


<210> 3049
<211> 1946
<212> DNA
<213> Homo sapiens

<400> 3049
atcgcggacg cagcctcgtg ccgggagtcg ccgcattgtg gtccgcttct ctgcactatg       60

tcgggtggcc tcctgaaggc gctgcgcagc gactcctacg tggagctgag ccagtaccgg      120

gaccagcact tccggggtga caatgaagaa caagaaaaat tactgaagaa aagctatgcg      180

gaaaacgcca tgcggtacat aaatgggacg cgtctggatg accgaatcat tcgcacagac      240

tgggacgcag gctttaagga gggcaggcaa tacggccgtg ggcgatctgg gggccaggtt      300

cgggatgagt atcggcagga ctacgatgct gggagaggag gctatggaaa actggcacag      360

aaccagtgag tggtgagagc tctgtcagtg acaaacactc ctttggcctg ttgaatttgc      420

tgaagaacat cacctaaagt ctgcacacga gcccattttt accaagattt gatcagtgtc      480

tttactgagc tggaagcctc tgaaagttat taaaggacag aatccaaaag aatgccttta      540

attcttgtct gagaatcttg gccatgtgtc agattatcag aacaattttg ttaccaggtc      600

agaaattgtg ttctttgaca acagattgga tctgtaatgt tgattagtct ttagccataa      660

ccactacact tttagaaaga cagaaaaatg taagaatttg tttttaccat aatgagtctt      720

aagtaggttc atgatctaca ttggggcctg ggattatttt tttaatttta agtttgcatg      780

agatagccta ataaatggag gtggggccag gcatggtggc tcacacgtgt aatcccaaca      840

ctttgggagg ctgaggagga aggatagctt gaggccagga gtttgagact agactgggca      900

acatagcaag accccgtctc tacaaagcac aacgaaaaac aacaaatgga gttgtgctat      960

gttgtattgc tttgcacaaa attaggaaca ggtgtttgac aattgaattt gttttctgtg     1020

aattctaacc tctaaaggca tgcttagagg tcaaggacct tcctgtgtag ttggtgcaaa     1080

agcaatctcc acaggacagc actgcttcca tgcttcatac atcaggaaat gaggccagaa     1140

cttgagtatt tactaacacg tttttcaaaa gatgtcagtg ttatacctaa agctaaaaaa     1200

aagcaagggt ttgtcataga gggaacctct aaataatttc aggggtaggg gagatgttgt     1260

caataggaaa tgggataaaa tatcaagaga caatgaaaac actgccttga catgaggacc     1320

agcaagttta ttcttttcat tttcagtgat gttgggaatg gactgggttt taaaagggag     1380

cttgaagagg gaatgtttga cagtcacaga aggttcctgc agcagatgcc tcttttagcc     1440

atttctcatt tttttcctca aattttacct actgaggctc aagccttcac agtgagctga     1500

tggtctctac agggagggga gtctagggaa tttatttggt atttgtaagg caagaggtga     1560

tttctctcta atatatctga gttattgctc atttaaaact gttaagtcca gtataatttt     1620

ccctgatatg aaaaaatgtg catttttttc acttagcaac aaagtacctt ctaatttcca     1680

atagtccgtg aaagttgggg ctgaagtacc taagtgtgaa tgtctctccc gttaaactga     1740

gtgtagaaat ctgaattttt aaaagagctg taactagttg taagtgctta ggaagaaact     1800

ttgcaaacat ttaatgagga tacactgttc atttttaaaa ttccttcaca ctgtaattta     1860

atgtgtttta tattcttttg tagtaaaaca acataactca gatttctaca ggagacagtg     1920

gttttattcg gattgtcttc tgtaat                                          1946


<210> 3050
<211> 1162
<212> DNA
<213> Homo sapiens

<400> 3050
tgcccctcta ccatgtggcc cttcccgagc cgctctctct tcccaccccc gactcaggcc       60

tggctccaga cggtctcctc agaccctgag gcccagggct ggggggcctg gaacgagacc      120

aaggagattc tggggccaga gggtggggaa gggaaggagg agaaagagga ggaagaggat      180

gcagaggaag accaggatgg ggatgcaggc tttctgctgt ctctgctgga gcaagagaac      240

ctggctgagt gcccattgcc tgaccaggag ctggaggcca tcaagatgaa ggtgtgtgcc      300

atggagcagg ccgaggggac gccacggcct ccaggagtgc agcaacaggc cgaggaagag      360

gagggcaccg cggccgggca gctgctgagc cctgagaccg tgggctgccc cctctctggg      420

acccccgagg agaaggtgga ggctgaccac agatccgtct acgtgggcaa cttatgccta      480

catagagttt gccaccaagg gctccgtgca ggccgccgtg gagctggacc agagcctctt      540

ccggggccgg gtcatcaagg tgctgccgaa aagaaccaac ttccctggga tcagctccac      600

agaccgcggg ggccttcgag gacacccagg ctccaggggg gcacccttcc cccacagcgg      660

cctccagggc aggccccggc tcagaccaca agggcagaac cgggcccgtg gaaaattctc      720

accatggttt tcaccgtatt aaagggaaga cccgattttg agagaggggc tggggcctgg      780

atcaggagta aaccacttgt gctccatcct ggggctgggg cagggagtgg cgcgggggcg      840

aggccagagg agaggggtgt ccagagcagc cactggcccc ctcttggcgg ggggatggcc      900

cagtagggcc ttgtatggtg gtccagaccc aaggccacag ccacgagtca cagccacggc      960

ccggtggtga gcctggcatg ggccccacgg ggatctgcgg ggctctgggt gttgagggag     1020

gggaggagca gagtcccagg cagtgccagg ccagcttggg gttggcatgc tcagctcttc     1080

aactaagtca ttttaagaaa aatagaaacg tgtgtcttaa tggtgaagca taaattatta     1140

aacttgggct ctttttaaaa gc                                              1162


<210> 3051
<211> 1561
<212> DNA
<213> Homo sapiens

<400> 3051
cttcgatgat ttactgaaat ttgatgacct agatggaaca catgctctga tgtcccgcat       60

ggtccagaat gagatcccct acttcatctg gaccactcgg cgggatgtgc tcgactgtcg      120

cttcctctcc aaggatcaga tgataaacca ctacgcccgg gctggctcct ttaccacaaa      180

ggtgggtcta tgtctcaatc tccggaattt gccgtggttt gatgaggttg atgccaactc      240

cttcttccca cgctgctact gcctgggggc tgaggatgac aaaaaagcct tcatagagga      300

cttctggctg actgctgccc gcaacgttct caagctggtg gtgaagtctg agtggaagtc      360

ataccctatt caggcagtag aggaagaggc ctcaggagac aagcagccca agaaacagga      420

gaaaaaccca gtgttggtgt ccccagagtt tgtggatgaa gctctgtgtg cgtgcgagga      480

gtaccttagc aacttggccc acatggacat cgacaaggac ctggaggccc cgctgtacct      540

cacccccgag ggctggtccc tcttcctcca gcgctactac caagtggtcc acgaaggggc      600

agaactcagg cacctcgaca ctcaggtcca gcgctgtgag gacatcctgc agcagctgca      660

ggccgtggta ccccagatag acatggaagg ggatcgcaac atctggatcg tgaagccagg      720

agccaagtcc cgcggacgag gcatcatgtg catggaccac ctggaggaga tgctgaagct      780

ggtgaacggc aaccccgtgg tgatgaagga cggcaagtgg gtggtgcaga agtatattga      840

gcggcccctc ctcatctttg gcaccaagtt tgacctcaga cagtggttcc tggtaactga      900

ctggaaccca cttaccgtgt ggttctaccg cgacagctat atccgctttt ccacgcagcc      960

cttctccctg aagaacctgg acaactcagt gcacctgtgc aacaactcca tccagaagca     1020

cctggagaac tcatgccatc ggcatccact gcttccgcca gacaacatgt ggtctagcca     1080

gaggttccag gcccacctgc aggagatggg tgccccaaat gcttggtcca ccatcatcgt     1140

gcctggcatg aaggatgctg tgatccacgc acttcagacc tcccaggaca ccgtgcagtg     1200

tcggaaggcc agctttgagc tctatggcgc tgacttcgtg ttcggggagg acttccagcc     1260

ctggctgatt gagatcaacg ccagccccac gatggcaccc tccacagcag tcactgcccg     1320

gctctgtgct ggcgtgcaag ctgacaccct gcgcgtggtc attgaccgga tgctggaccg     1380

caactgtgac acaggagcct ttgagctcat ctataagcag cccgtcacca cttccccagc     1440

ctccacacca aggcccagct gccttctccc catgtactcc gacaccaggg ccaggtcctc     1500

agacgacagc acagcaagct ggtgggcact aaggccctgt cgaccacagg caaggccttg     1560

a                                                                     1561


<210> 3052
<211> 441
<212> DNA
<213> Homo sapiens

<400> 3052
tgcaagaggg tgacagcaac acactcaagg cgcttctcct gggaatggag caggagaaga       60

gatggggagc atcgcataga tggaactaga cctttttctt gggttggatg atgtgttccc      120

gcgtctacta catggattat tgcatcgagc ttttagtgtc ttcttattca acaccgaaaa      180

taagcttctg ctacagcaaa gatcagatgc taagattacc tttccaggtt gttttacgaa      240

tacgtgttgt agtcatccat taagcaatcc agccgagctt gaggaaagtg acgcccttgg      300

agtgaggcga gcagcacaga gacggctgaa agctgagcta ggaattccct tggaagaggt      360

aaccagctct cctacacaac catacaagct gaaacctaaa catactataa aaaggttttt      420

aataaaattt ttaaattcaa a                                                441


<210> 3053
<211> 567
<212> DNA
<213> Homo sapiens

<400> 3053
gttttggggt cgcagcgggg tggcagcttg ttttgccttc acgggagtag aaggaggcgg       60

cgtccggccg cggccgacgg tagttcgctt ccccgagagt gcgcggaggc ccgggtgcga      120

ggagggcctg tttctcttca gccctggttc attcacctcg cggaccgagg gccccgccgt      180

caggagccgg cgaccgtgcc ctgtgatggt cattgtcctc cagagcagtg atggaggaaa      240

taccagccca ggaagcagca gggtcaccaa gggtccagtt tcagtctttg gagacccagt      300

ctgagtgtct gtccccagag cctcagtttg tgcaggacac cgacatggaa cagggactca      360

ctgggggatt tccaatttcc aagcctgatg ggatctccca gctggaacag gatctacagg      420

tctttgatct ggaaactaag actagagaag tcttaagaga tgactgctca gatggagaga      480

ccagagaaga gaacaagctg ttgattccta agcagaaaat ttcggaagaa gtgcattcat      540

acaaagtgag agtaggaaga ctcaaac                                          567


<210> 3054
<211> 2363
<212> DNA
<213> Homo sapiens

<400> 3054
gatttaaaac cagctcagga gacgccaagg aaagatggga cctcccggcc caggagtatt       60

gacatttcag ctactatccc caagtttaca aacacgcaga ttacggaaca ttactccacc      120

tgtatcaaac tgtccactga aaataaaatc actaccaaga atgcttttgg tttgcacttg      180

attgatttta tgtcagagat tcttaaacag aaagacaccg aaccaaccaa ctttaaagtg      240

gctgcgggta ctctggatgc cagcaccaag atctatgctg tgcgcgtgga tgccgtccat      300

gccgatgtat acagagtcct tggggggctg ggcaaagatg caccgtcttt ggaagaagta      360

gaaggccatg ttgctgatgg aagtgctact gaaatgggaa caaccaaaaa ggctgtaaag      420

ccaaagaaga agcacttaca cagaactatt gagcagaaca taaacaacct caatgtctcc      480

gaagcagatc ggaagtgtga gattgatccc atgtttcaga agacagcagc ctcatttgat      540

gagtgcagca cagcaggggt gtttctgtcc actctccact gccaggacta cagaagtgaa      600

ctgctgtttc cctctgatgt ccagactctc tccacgggag aacctctcga gttgccagag      660

ttaggttgtg tagaaatgac agatttaaaa gcgcccttgc agcagtgtgc agaagatcgc      720

cagatctgcc cttccctggc cgggttccag tttacacagt gggacagtga aacacataat      780

gagtctgtgt cggccctggt agacaagttt aagaagaatg accaggtatt tgacatcaat      840

gctgaagttg acgagagtga ctgtggagac ttccccgatg ggtccctggg ggatgacttt      900

gatgccaacg atgaacctga ccacaccgca gttggggatc atgaagagtt caggagctgg      960

aaggagccct gccaggttca gagctgccag gaagaaatga tttcccttgg ggatggagac     1020

atcaggacca tgtgccccct tctgtctatg aaacctggag aatattctta tttcagtcct     1080

cggaccatgt cgatgtgggc tggcccggat cactggcgct ttaggcctcg acgcaaacaa     1140

gatgctcctt cccaatcaga aaacaaaaag aagagtacaa aaaaagattt tgaaattgac     1200

tttgaagatg atattgactt tgatgtatat tttagaaaaa caaaggctgc tactattctg     1260

accaagtcca ctttggagaa ccagaattgg agagctacca cccttcctac agatttcaac     1320

tacaatgttg acactctggt ccagcttcac ctcaaaccag gcaccaggtt acttaagatg     1380

gcccagggcc atagggtaga gactgagcat tatgaagaaa ttgaagacta tgattacaac     1440

aaccctaacg acacctccaa cttttgccct ggattacagg ctgctgacag tgatgatgaa     1500

gatttggatg acttatttgt gggacctgtt gggaactctg acctctcacc ttatccttgc     1560

catccaccta agacagcaca acagaatggt gacactccag aagcccaagg attagacatc     1620

acaacatatg gggagtcaaa cttggtagct gagcctcaga aggtaaataa aattgaaatt     1680

cactatgcca agactgccaa aaagatggac atgaagaaac tgaagcagag catgtggagt     1740

ctgctgacag cgctctccgg aaaggaggca gatgcagagg caaaccacag ggaagctgga     1800

aaagaagcgg ccctggcaga agtggctgac gagaagatgc ttagcgggct cacgaaggac     1860

ctgcagagga gcctgccccc tgtcatggct cagaacctct ccatacctct ggcttttgcc     1920

tgtctcctac atttagccaa tgaaaagaat ctaaaactgg aaggaacaga ggacctctct     1980

gatgttcttg tgaggcaagg agattgagtt cactatggag aagtcagcag caggaggccc     2040

atcccttact cagttgccgg gacatcccca gtctcggggg aagaagatgc catgggctta     2100

tacccaggct gtagccaact accaacgtgc ctgtttgttt gttgctcttt ccttctctcc     2160

atcatagtct gggtgccagc gccctgaagc tccgtgctca actgattaaa ctttactgcc     2220

ctatggtgac catctaggag aggggagggc agagggggtg agggtactat tctggattga     2280

gaaaacctat atccattctt tatatcaatg tatagtttta gtctcctaaa ttgatctgtt     2340

attttccaaa ctattctctt gta                                             2363


<210> 3055
<211> 3498
<212> DNA
<213> Homo sapiens

<400> 3055
aactcggtga aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac       60

ccatctccag ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca      120

ccagtggccg agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct      180

caccatgagt tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga      240

gctcaagaag cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca      300

ggctgcgctg gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcga      360

cgatcagggt ttccaggaag gggaagatga gctcggggac gaagaggaag gcgcgggcga      420

cgagaacggg cacggggagc agcagcctca accgccggcg acgcagcagc aacagcccca      480

acagcagcgc ggggccgcca aggaggccgc ggggaagagc agcggcccca cctcgctgtt      540

cgcggtgacg gtggcgccgc ccggggcgag gcagggccag cagcaggcgg gaggtaagaa      600

gaaggcggaa ggcggcggag gcggcggtcg ccccggggct ccggcggcgg gggacggcaa      660

aacagaacag aaaggcggag ataaaaagag gggtgttaaa agaccacgag aagatcatgg      720

ccgtggatat tttgagtaca ttgaagagaa caagtatagc agagccaaat ctcctcagcc      780

acctgttgaa gaagaagatg aacacttcga tgacacagtg gtttgtcttg atacttataa      840

ttgtgatcta cattttaaaa tatcaagaga tcgtctcagt gcttcttccc ttacaatgga      900

gagttttgct tttctttggg ctggaggaag agcatcctat ggtgtgtcaa aaggcaaagt      960

gtgttttgag atgaaggtta cagagaagat cccagtaagg catttatata caaaagatat     1020

tgacatacat gaagttcgta ttggctggtc actaactaca agtggaatgt tacttggtga     1080

agaagaattt tcttatgggt attctctaaa aggaataaaa acatgcaact gtgagactga     1140

agattatgga gaaaagtttg atgaaaatga tgtgattaca tgttttgcta actttgaaag     1200

tgatgaagta gaactctcgt atgctaagaa tggacaagat cttggcgttg ccttcaaaat     1260

cagtaaggaa gttcttgctg gacggccact gttcccgcat gttctctgcc acaactgtgc     1320

agttgaattt aattttggtc agaaggaaaa gccatatttt ccaatacctg aagagtatac     1380

tttcatccag aacgtcccct tagaggatcg agttagagga ccaaaggggc ctgaagagaa     1440

gaaagattgt gaagttgtga tgatgattgg cttgccagga gctggaaaaa ctacctgggt     1500

tactaaacat gcagcagaaa atccagggaa atataacatt cttggcacaa atactattat     1560

ggataagatg atggtggcag gttttaagaa gcaaatggca gatactggaa aactgaacac     1620

actgttgcag agagcccccc agtgtcttgg gaaatttatt gagattgctg cccgaaagaa     1680

gcgaaatttt attctggatc agacaaatgt gtctgctgct gcccagagga gaaaaatgtg     1740

cctgtttgca ggcttccagc gaaaagctgt tgtagtttgc ccaaaagatg aagactataa     1800

gcaaagaaca cagaagaaag cagaagtaga ggggaaagac ctaccagaac atgcggtcct     1860

caaaatgaaa ggaaacttta ccctcccaga ggtagctgag tgctttgatg aaataaccta     1920

tgttgaactt cagaaggaag aagcccaaaa actcttggag caatataagg aagaaagcaa     1980

aaaggctctt ccaccagaaa agaaacagaa cactggctca aagaaaagca ataaaaataa     2040

gagtggcaag aaccagttta acagaggtgg tggccataga ggacgtggag gattcaatat     2100

gcgtggtgga aatttcagag gaggagcccc tgggaatcgt ggcggatata ataggagggg     2160

caacatgcca cagagaggtg gtggcggtgg aggaagtggt ggaatcggct atccataccc     2220

tcgtgcccct gtttttcctg gccgtggtag ttactcaaac agagggaact acaacagagg     2280

tggaatgccc aacagaggga actacaacca gaacttcaga ggacgaggaa acaatcgtgg     2340

ctacaaaaat caatctcagg gctacaacca gtggcagcag ggtcaattct ggggtcagaa     2400

gccatggagt cagcattatc accaaggata ttattgaata cccaaataaa acgaactgat     2460

acatatttct ccaaaacctt cacaagaagt cgactgtttt ctttagtagg ctaacttttt     2520

aaacattcca caagaggaag tgcctgcggg ttcctttttt agaagctttg tgggttgatt     2580

ttttttcttt tcttttttgt acatttttaa ttgcagttta aaagtgaatc gtaagagaac     2640

ctcagcattg tgcacgataa gagaatgtgt cagtatttca gggttctaca ttttatctgt     2700

aaaatgtgac tttttttttt ttttatcaca acagaagtaa aatgttgctt tgtacctggt     2760

gtcttttatt aagaatttac tccccccatt tctcacagag aataacagtc gggagtcatt     2820

gtcacaatat aatagaaatg ttagcaacca gattcatgta aggactaagt ggtcctcatg     2880

aattgcatta agactctgta ctgctcatat tacactccat cctctctgta gtttgctggg     2940

tagtggaggg ggtaagctaa atcatagttt ctgacaataa ctgggaaggt tttttcttaa     3000

aataacaatg gaattggtat aattgggatt gaaaactaaa acttggaact aagatagaga     3060

agatggagtg tatgtagaag ggctgttaaa aatgtaaaac ttggttgcat tatttgtgga     3120

ggctcaaact tgtgaaggtt aataccataa tttttccatt tgttctgcat tttgattctg     3180

aaaagaaagc tggctttgcc catttcttat taaaaaaact tgttgtaaat ccagttgtct     3240

aatgggatct atatgaagtt agccatgtct gtatgccctt ctcccacaaa atactgtata     3300

actagtgtgc ttgtagtagt taactccacc atctttgtaa gctaatgaaa ttgtgagtca     3360

cccatttata tcttaatttt taatcatgtc agttcttgaa tgggtatctc cttagcctgc     3420

tgatttcttt ttctttctaa agaaagtggg tggagaaatt aatttagacg tttgtttgca     3480

ataaaaagaa ttcatttt                                                   3498


<210> 3056
<211> 1012
<212> DNA
<213> Homo sapiens

<400> 3056
gggggtcggg gccgcagaag tgccagacgg ggccggaaag cagccgagcg gagttcaaat       60

ttgagagcgt ttggaaattg gaagacttgg tggcgaacga gggtcaggac ctgcatcctg      120

cctcagagtt atcgacgtat ccggaatgtg ggatcagagg ctggtgaagt tggccctgtt      180

gcagcatctg cgggccttct atggtattaa ggtgaagggt gtccgtgggc agtgcgatcg      240

caggagacat gaaacagcag ccacggaaat agggggtaaa atatttggag taccttttaa      300

tgcactgccc cattctgctg taccagaata tggacacatt ccaagctttc ttgtcgatgc      360

ttgcacatct ttagaagaac atattcatac cgaagggctt tttcggaaat caggatctgt      420

gattcgccta aaagcactaa agaataaagt ggatcatggt gaaggttgcc tatcttctgc      480

acctccttgt gatattgcgg gacttcttaa gcagtttttt agggaactgc cagagcccat      540

tctcccagct gatttgcatg aagcactttt gaaagctcaa cagttaggca cagaggaaaa      600

gaataaagct atactgttgc tctcctgtct tctggctgac cacacagttc atgtattaag      660

atacttcttt aactttctca ggaatgtttc tcttagatcc agtgagaata agatggatag      720

cagcaatctt gcagtaatat ttgcaccaaa tcttcttcag acaagtgaag gacatgaaaa      780

gatgtcttct aacgcagaaa agaagggcgt gtaccagact ttatcctgga aaagatacca      840

gccatgttgg gtattgatgg tctctgtgct actccatcac tggaaggctt tgaagaaggt      900

gaatatgaaa ctcctggtga atataagaga aagagaagac aacgtgtagg agattttgtt      960

agtggagcac taaataaatt taaacctaac agaacacctt ctattacacc tc             1012


<210> 3057
<211> 918
<212> DNA
<213> Homo sapiens

<400> 3057
tcatgagagt ggaggctgcg gccggggcta tgggcagagg tggccgggtc tgcttcttcc       60

ctgtcactgc cgcagcagct tggggtgcaa ggcggcctgg ggcggcggaa ggggcgcccc      120

ccgagttccg tctgaggaag cggcggctgc cgaggaagtc cacgagagcc gggtcccgca      180

cgcccctggg gtccgggtgc tgaggcgccg cctggccgcc tccccgggcc gcggcaccgc      240

tccgacccag ccgccctctc caccggggcc gcggcagcgc cagtcggggc ccttccctct      300

aagcagccca aacgtgcaga atgccccaca agattggatt tgtagtcgtc agctcatctg      360

gacacgaaga cggcttcagt gcccgggagc tcatgatcca cgcgccaact gtcagtgggt      420

ggcggtcacc tagctacgtg tctctctgtg ataatgaaaa gacaggttgc aaagcccggg      480

aactaaaatc agtttatgtg gatgcagtag gacaatttct taaactgatt tttcaccaaa      540

accatgtcaa caaatacaac atatataatc aggttgcttt ggttgccata aatatcattg      600

gagaccctgc agatttcagt gatgaaagca atactgcctc tcgagagaag ttgattgacc      660

actaccttgg gcacaacagc gaggaccctg ctctagaagg aacgtacgcc aggaaatctg      720

actatatctc tccgctagat gacttagctt ttgatatgta ccaagatcca gaagttgcac      780

agatcatacg aaaattagat gaaagaaaac gggaagctgt ccaaaaggaa cgctatgatt      840

atgccaagaa actaaaacaa gccattgctg atttgcaaaa ggttggtgaa cgccttggga      900

ggtatgaggt agagaaac                                                    918


<210> 3058
<211> 832
<212> DNA
<213> Homo sapiens

<400> 3058
caacagggac cgaccaaatc gtcatgcagc tgtttggatg ctttaaaaaa ataaatcccc       60

acactcatta cgcgttttat gctgctgact tttttatttt taagacatct gctcccgaaa      120

gctcagagcc ctttagcatt tcattttcta aacgaatcct aatctttcct gtgactgaat      180

cggttcagag gatatctttt caataaggaa ggaagccctc ccctgctcac tggggacgtc      240

gcagggtttt taaacctaaa gatttactct tttgtgcaca gacgctggaa gcatttggac      300

tcacttttcc ccttcgtctt tctctccctt tctgtctttc tgtgtctcct ccaagaatga      360

aatatgactg aggactctca gagaaacttt cgttcagtat attatgagaa agtggggttt      420

cgtggagttg aagaaaagaa atcattagaa attctcctaa aagatgaccg tctggatact      480

gagaaacttt gtacttttag tcagaggttc cctctcccgt ccatgtaccg tgcattggta      540

tggaaggtgc ttctaggaat cttgcctcca caccacgagt cccatgccaa ggtgatgatg      600

tatcgtaagg agcagtactt ggatgtcctt catgccctga aagtcgttcg ctttgttagt      660

gatgccacac ctcaggctga agtctatctc cgcatgtatc agctggagtc tgggaagtta      720

cctcgaagtc cctcttttcc actggagcca gatgatgaag tgtttcttgc catagctaaa      780

gccatggagg aaatggtgga agatagtgtc gactgttact ggatcacccg ac              832


<210> 3059
<211> 3605
<212> DNA
<213> Homo sapiens

<400> 3059
gagccccaga gcgcggcggc agcggcggcc tggcccttcc agagggccag agccagggac       60

atgcgggcgc ccgggactcc gcgttccgcg cggcccggcg cctgagcgcc tccgttcccc      120

gtcccggagc tgccggcggc atgatccgac acgccggggc gcccgcgcgc ggggacccca      180

cgggtccggt tccagttgtt ggcaaaggag aggaagagga agaggaagat ggcatgcggc      240

tttgtctgcc agccaacccg aaaaactgcc ttcctcaccg ccggggcatc agcatcctgg      300

agaagctcat caaaacatgc ccggtgtggc tgcagctgag tctgggccag gcagaggtgg      360

ccaggatcct gcaccgggtg gtggctggga tgttcctggt tcgccgggac agcagctcga      420

agcagctggt gctctgtgtc cactttcctt ctctgaacga aagctcggcc gaggtgctcg      480

aatacaccat taaggaagaa aagtcgatat tgtacctgga aggctcggct cttgtgtttg      540

aggacatctt cagattgatt gcgttctact gtgtcagtag agacttactg cccttcacac      600

tgcggctacc ccaggccatc cttgaggcca gcagcttcac ggaccttgag accatcgcca      660

acctgggtct gggtttctgg gactcctcgc tgaatcctcc acaagaaaga gggaagccag      720

cagagccccc aagagaccgg gcccccggat tccccctagt ctccagcctc aggcccacag      780

cccatgacgc aaactgtgcc tgtgaaatcg agctgtcggt aggaaatgac cgcctgtggt      840

ttgtgaatcc tattttcatc gaggactgca gcagcgccct gcccaccgac cagccacctc      900

ttggaaattg ccctgcacgc cctttgccgc ccacctctga tgccacctca cccacctcca      960

ggtgggcccc acgccgccca ccaccccctc ccccagtgct gcccctgcag ccctgcagcc     1020

cagcccagcc cccgccactg cctgcgaaga agaaccttcc cactgcccct cccagacgcc     1080

gcgtttccga gagggtgtcc ttagaagacc aaagtccggg gatggcggca gagggggacc     1140

agctcagcct gcctccccaa gggacctcag acggccctga ggacacgccc cgggagagca     1200

cggagcaagg ccaggacaca gaggtgaaag ccagcgatcc tcacagcatg ccagagctgc     1260

ccaggacagc caaacaaccc ccagtcccgc cccccaggaa aaaacggatc tctcgacaac     1320

tggcctcgac cctcccagct cccttagaga acgctgagct ctgcacacag gcgatggcct     1380

tggagacacc cacgccgggt ccacccagag agggccaaag ccctgcttct caggctggga     1440

ctcagcaccc tcctgcccag gccactgccc attcccagag ctctccagag ttcaagggct     1500

ccctggcctc cctctcagac agcttggggg tgtctgtcat ggccaccgac caggactcct     1560

actccaccag cagcacggag gaggagctgg agcagttcag cagccccagc gtgaagaaga     1620

agccctccat gatcctgggc aaggctcggc accggctgag ctttgccagt ttcagcagca     1680

tgttccacgc tttcctctcc aacaaccgca agctgtacaa gaaggtggtg gagctggcgc     1740

aggacaaggg ctcgtacttt ggcagcctgg tgcaggacta caaggtgtac agcctggaga     1800

tgatggcgcg ccagacctcc agcacggaga tgctgcagga gattcgcacc atgatgaccc     1860

agctcaagag ctacctgctg cagagcaccg agctcaaggc cctggtggac cccgccctgc     1920

actccgagga ggagctcgaa gcaattgtag agtctgcctt gtacaaatgt gtcctgaagc     1980

ccctgaagga agccatcaac tcatgcctgc atcagatcca cagcaaggat ggttcgctgc     2040

agcagctcaa ggagaaccag ttagtgatcc tggccaccac caccactgac ctaggtgtga     2100

ccaccagcgt gccggaggtg cccatgatgg agaagatcct gcagaagttc accagcatgc     2160

acaaggccta ctcacctgag aagaagatct ccatcctgct caagacctgc aaactcatct     2220

acgactccat ggccctcggc aacccaggga agccctatgg ggcggatgac ttcctgcctg     2280

tgctcatgta tgtgctggcc cgcagcaacc tcacggagat gcttctcaat gtggagtaca     2340

tgatggagct catggacccc gccctgcagc tgggggaggg ttcctactat ctgaccacca     2400

cctacggggc cctggagcac atcaagagct acgacaagat cacggtgacc cggcagctga     2460

gtgtggaggt gcaggactcc atccaccgct gggagcgccg gcgtactctc aacaaggccc     2520

gggcctcccg ctcctccgta caggacttca tctgcgtgtc gtacctggag cccgagcagc     2580

aggcgcggac gctggcgtcg cgggcggaca cccaggccca ggcgctgtgc gcgcagtgcg     2640

cggagaagtt cgcggtggag cggccgcagg cgcaccggct gttcgtgctg gtggacgggc     2700

gctgcttcca gctggcggac gacgcgctgc cgcactgcat caagggctac ctgctgcgca     2760

gcgagcccaa gcgcgacttc cactttgtct accggcccct ggacggtggt ggcggcggcg     2820

gcggcgggag cccgccctgc ctggtggtgc gggagcccaa cttcctgtga ggccctcccg     2880

gggcgcctcc cctcaccccc aggcgcacgt ctggccccgc ctctggctgc gcactcccga     2940

ccgcgacgtc cacgcagcag agggacatgg gccattccat gacgtgccca ggccaacgtc     3000

gcaggacagt tgtgaaaata acatgacgct cgtccaaggc cacttcctga gggcaagtcc     3060

taatagccct gagacaccga gacggcatgt tcttcattag acggaaaggg aaactgaggc     3120

tcaggagaga ggcgctccag gccgctgcag ccaacaaacc ggcgccctct tcacacgtag     3180

ctcctcaggc cattccccat gagtccccca cacccacccc atcctcggtc tttgcaaaga     3240

agggcccgag cttagtttcc ccaggactgg cctaggaagg agcaccggcc acagctgctc     3300

cccgtgccac tcagggtgga cccagcatct caggagcacc tcagggtgtc ggttaagaga     3360

caggcctcca cccctgcacc agagcctgct cttagctccc ggtgccccca gaccccgcag     3420

ctctgtgccc ggcaagaagc agctagacac acgccagggc gccaagcacg gccagctccg     3480

cggacccatg gacaagccca gccccgcctc agggaaaaca gggcctttcc ctacaggaca     3540

cgccccagag ctgtggcaga ttgcaggagc catcgtgtgg ggagaattta ataaaagccc     3600

ttttg                                                                 3605


<210> 3060
<211> 2229
<212> DNA
<213> Homo sapiens

<400> 3060
tgaaacaaag gaccaatgcc cagggcggtc cttaattcct ccctgcagtt tgaaactgtc       60

aggttgccgt ctaggtagcg gttgtgcttg ctgaggctgc acttgctgac actgcagctg      120

cgacgcggct aagaggcgca gagcgaggag tcgggatttg gtcgcgagcg gcgacgagca      180

tttgtgcaga atgtcatcag atgaggagaa atactcactt ccagttgtgc aaaatgactc      240

cagtcgaggc agttctgtct cttcgaatct tcaggaagaa tatgaagaac tgcttcatta      300

tgctatagtg actccaaata ttgaaccctg tgcttcacag tcatctcatc ctaagggaga      360

attggtgcca gatgtcagaa tttctacaat tcatgatatt cttcatagtc aaggaaataa      420

ctctgaagta agagaaactg caatagaagt tggaaaagga tgtgatttcc atatttcaag      480

tcattcaaag acagatgagt catcaccagt gttatcgcca aggaagcctt ctcacccagt      540

catggatttt ttcagttcac atcttttagc tgactcttcc tcaccagcaa caaattctag      600

tcatacagat gcccatgaaa tacttgtgag cgattttctt gtttctgatg aaaaccttca      660

gaagatggaa aatgtgcttg atctttggag ttcaggtctt aagacaaaca tcatatctga      720

actaagtaaa tggagactta attttattga ctggcaccga atggaaatga gaaaagagaa      780

agaaaaacat gcagcacatt taaaacaact gtgtaatcag atcaatgaat tgaaggagct      840

gcaaaaaacc tttgaaatct ccattgggag aaaagatgag gtgatttcta gcttgtctca      900

tgccataggc aagcaaaagg aaaagataga gttgatgaga acattcttcc actggcgaat      960

cggccatgtc agagccagac aggatgttta tgaaggtaaa ctagctgacc agtactacca     1020

gagaacttta ctgaagaaag tctggaaagt ctggcgttcc gtagtgcaaa agcagtggaa     1080

agatgtggta gaaagagctt gtcaagcaag agctgaagaa gtttgtatcc agatttccaa     1140

tgattatgaa gccaaagttg ctatgttatc tggagctttg gaaaatgcaa aagctgagat     1200

tcaaagaatg caacatgaaa aagagcactt tgaagattcc atgaaaaaag ctttcatgag     1260

gggtgtatgt gcattaaatc ttgaagccat gactatattt caaaacagaa atgatgcagg     1320

gatagactcc acaaataata aaaaggaaga gtatggtcct ggtgttcaag gaaaagaaca     1380

ttctgctcat ttggatcctt cagctcctcc gatgccctta ccagttacat caccactgct     1440

gccatcccca ccagccgccg tcggaggagc cagcgcgact gccgttccct cagctgcttc     1500

gatgacttct accagggctg cttccgcatc ttctgttcac gttcctgttt ctgctcttgg     1560

tgcaggatct gcagctactg ctgcatcaga agaaatgtat gtgccaagag ttgtaacctc     1620

tgcacaacag aaagcaggaa gaactattac agcccggatc acaggaagat gtgattttgc     1680

ttcaaaaaat agaattagca gcagtttagc tataatggga gtttctcctc ccatgagctc     1740

agttgttgtg gaaaaacatc atccagtcac agtgcaaacc attcctcaag caactgcagc     1800

aaaatatccc cggaccattc atcctgaaag tagtacctca gcttccagat cacttggaac     1860

cagatcagct cacacccagt ctctcacaag tgttcattcc ataaaagtgg ttgactaaag     1920

tgaatatgtc catagtgggg tcttttaatc cctctggtct taccaagggt tagaagtctt     1980

ttggttttaa cttttccata ttgttagaac atcatggaga catcatgttc atctgttcaa     2040

aattacaaga ggctttttca agctctacca tgctttgtaa ctatatgtag aaattatttt     2100

aatgttattt tttatttaag caattaagta aaactttttt aaattaaaaa agaaactgga     2160

ctttatttct ttaatatgtt tagcctgttg ctgattacag catcaaaata tataaattta     2220

ttttcacta                                                             2229


<210> 3061
<211> 2665
<212> DNA
<213> Homo sapiens

<400> 3061
gtttaccact actacagtcg aatggccaac tatcggaaca cgagcgagat tcctctggtt       60

ctggtgggaa cccaggatgc cataagttct gctaacccga gggtcatcga tgacgccagg      120

gcgaggaagc tctccaacga cctgaaacgg tgcacgtact acgagacgtg tgctacatac      180

gggctgaatg tggagagggt cttccaggac gttgcccaga agattgttgc cacaaggaag      240

aagcagcagc tgtccatagg accctgcaag tcgctaccta attctcccag ccattcctcc      300

gtctgttccg cgcaggtgtc tgccgtgcac atcagccaga caagtaatgg aggtgggagt      360

ttaagcgact attcctcctc cgttccatcg actcccagca ccagccagaa ggaacttcgg      420

atcgatgttc ctcccactgc caacacgccc acgcccgttc gcaagcagtc taagcgccgg      480

tccaacctgt tcacctctcg gaaagggagc gacccagaca aagagaagaa aggcctggag      540

agtcgtgcgg acagcattgg gagcggccga gccatcccaa ttaaacaggg catgctgttg      600

aagcgaagtg gcaaatcgtt gaataaagag tggaaaaaga aatatgtcac cctgtgtgac      660

aatggcgtgc tgacctatca tcccagttta catgattaca tgcagaatgt tcatggtaag      720

gagattgacc ttctgagaac cactgtgaaa gtcccaggga agaggccacc ccgagccacg      780

tcagcctgcg cacccatctc cagccctaaa accaatggcc tatccaagga catgagcagt      840

ttacacatct cacccaattc agggaatgtc actagtgcat ctgggtctca gatggcaagc      900

ggcatcagcc tggtctcctt caacagccga cccgacggca tgcaccagcg ctcctactca      960

gtctccagtg ccgaccagtg gagtgaggct acggtcattg caaactcggc catcagcagt     1020

gacacagggc tgggtgactc cgtatgctcc agccccagta tctccagcac caccagcccc     1080

aagctcgacc cgcccccctc ccctcacgcc aacagaaaga agcaccgaag gaagaaaagc     1140

actagcaact tcaaagccga cggcctgtcc ggcactgctg aagaacaaga agaaaatttt     1200

gagtttatca ttgtgtccct cactggccaa acatggcact ttgaagccac gacgtatgag     1260

gagcgggacg cctgggtcca agccatcgag agccagatcc tggccagcct gcagtcgtgc     1320

gagagcagca agaacaagtc ccggctgacg agccagagcg aggccatggc cctgcagtcg     1380

atccggaaca tgcgcgggaa ctcccactgt gtggactgcg agacccagaa tcccaactgg     1440

gccagtttga acttgggagc cctcatgtgc atcgaatgct cagggatcca ccggaatctt     1500

ggcacccacc tttcccgagt ccgatctctg gacctggatg actggccagt cgagctcatc     1560

aaggtgatgt catccatcgg gaacgagcta gccaacagcg tctgggaaga gagcagccag     1620

gggcggacga aaccatcggt agactccaca agggaagaga aggaacggtg gatccgtgcc     1680

aagtacgagc agaagctctt cctggccccg ctgccctgca cggagctgtc cctgggccag     1740

cacctgctgc gggccaccgc cgacgaggac ctgcggacgg ccatcctgct gctggcacac     1800

ggctcccggg acgaggtgaa cgagacctgc ggggagggag acggccgcac ggcgctgcat     1860

ctggcctgcc gcaaggggaa tgtggtcctg gcgcagctcc tgatctggta cggagtggac     1920

gtcacggccc gagatgccca cgggaacaca gctctggcct acgcccggca ggcctccagc     1980

caggagtgca tcgacgtgct gctgcagtac ggctgccccg acgagcgctt cgtgctcatg     2040

gccaccccta acctgtccag gagaaacaat aaccggaaca acagcagtgg gagggtgccc     2100

accatcatct gaggaacagc cgtgcccgcc tgctcgccgc acctgggacg cggcagcctc     2160

gccgcattct cgctcagaag tcgcagcacg tgagtcccgt cgcatcccct ccctcttcct     2220

ggtggccacc tccctcccgc ccacccactc tcaccccaaa caaaatcaca aaacctggac     2280

atccctcaag gggcgaagag gcggccggga gactgcagaa gtggctcctt ttcataaact     2340

cccctaaacc acacacagga gagagcgacg ggcctcggcc ctttgatgat agcacatggc     2400

gcaggaccct tgtcctggtg gcacaaggga tggggacgcg agggggaggg gaggcgagga     2460

acaaggagaa ggggcaactt tccttaactg gcagttgagc acatagtaca tttcccctct     2520

accaaacgga acacttggat tccatctctt ctctgaggag ctcgacggca taaatcagaa     2580

gcaagcacag agtttgtcag gtttgaagcc cctatgatgg tgtgtgtcaa atcagttgta     2640

gctaatctgt ccagggagaa tactg                                           2665


<210> 3062
<211> 3150
<212> DNA
<213> Homo sapiens

<400> 3062
gggtgggact ggcagagcta cggacaggtg ggagcagtca gacagcctga gagagggaga       60

ccagaacgca aagagagcga gagcattaag taggcaggga gaggcacaca gaaagataga      120

cagcaacact cgcgtgctcc ctccctccac acgccctcct cttaccgagc gaagcggcca      180

ggggcacaga gtgggagagg actgtgggca cagaagaccg gaagagggac gctgcattgc      240

tggtgggacg gagggattcg gacggacgga cagaccagcg cacagactgg cagcctgcga      300

gagtggcagc tttgagagca gagcgcagca aagcgagaat cccgcgccga gctgctagtc      360

ggacccacag acggtcggac tgacagacgt gcagacggac agaagagcag acaggaggcg      420

ggggcgcgtt cactcccggc ggccagccgg ccagagaagg cggcggtggc accttctgag      480

cgcgtccgga gcagagacca gcagcagcag gggcagcggg gacacaagcc gcgaccgagc      540

cgccgccgca gccctggctg ccacagctgt gtgggatccc agccgacact gcagaaagct      600

ccttttacta gcagttaaat aaatcgacca aaaacaaaac aaacaaacaa acccaacaac      660

aacaacaaca acaaaagcca agccaaaagc caaaacaaac aaatccagcc aaatcaatca      720

ttgagaaaca ataatattaa taaaatccaa aactaaatca aaccaatcaa ggcaccaaga      780

cgcagggggg atatccacag ttcgatcaag gttgacgatg tgtcacactg tgtaagggaa      840

tcgcatggag atgggcattc cgaactgtta atggggacat gggactccag ttgtctctga      900

tcacttgtgt ggattttcct ggcgtagaac gacagaagcc gctagtaagt cgccaagacc      960

tacagcagga attctgcacc aaagggcata aaatcttgtt attttaattt gcatctggga     1020

gaatgtctga gcaaggagac ctgaatcagg caatagcaga ggaaggaggg actgagcagg     1080

agacggccac tccagagaac ggcattgtta aatcagaaag tctggatgaa gaggagaaac     1140

tggaactgca gaggcggctg gaggctcaga atcaagaaag aagaaaatcc aagtcaggag     1200

caggaaaagg taaactgact cgcagccttg ctgtctgtga ggaatcttct gccagaccag     1260

gaggtgaaag tcttcaggat cagactctct gaaaactgca aatggaaagg aattcaaaag     1320

aatttagatt aaaagttaaa taaaaagtag gcacagtagt gctgaatttt cctcaaaggc     1380

tctcttttga taaggctgaa ccaaatataa tcccaagtat cctctctcct tccttgttgg     1440

agatgtctta cctctcagct ccccaaaatg cacttgccta taagaaacac aattgctggt     1500

tcatatgaaa cttaggaaat agtgaataag gtgcatttaa ctttggagaa atacttttat     1560

ggctttggtg gagatttctc aatactgcaa aagttgtcca gaaatgaatc tgagctgatg     1620

gtgactttaa gttaatatta ttaatatatc actgcatatt tttaccctta tttttgctcc     1680

ttacagcaag attagtaggt tataaaaatt taaatttaaa caaaattatt tcatgacaaa     1740

atgggaaact tcacatcata cttatttttg tttgcctttc aggcatcata ttagctttta     1800

taaaaaatgg tcttgctgct gaaattgtac ttattttatc agaggctggg tgcagtcaag     1860

acaaaagtaa aatggtttac ctgagcccag gggagggaaa attgattaag atatcattat     1920

ttttgtttgg tttggttttg cttttttcct cttactttaa ttgaaatact ctgaattccc     1980

ctcatggaaa cagagagcat tgagagcact ttctttaaaa ggaccaaaaa taaattccta     2040

atagattttg tcctaagaga gtgttttttt ttctagcatc attttcttta catgccactc     2100

atgtcataag gcatggacag gctatctttc agtggccatt actatgtttc gtacacatgc     2160

tttattttac ttgggctctg agaaatgtgt ggctttcctt cagcatttta tttgtgcttc     2220

tctttttaat ggagattgaa aagggagaat aatgtgaata tcacggctta tattattaaa     2280

tgttgattga tggcttgtaa tgtactgcac acaatatatg ttaactctgc agaatgacag     2340

accctgggag aagtaatgcc ccagttgtcc cccactccta atgccaggca gagaaggaca     2400

gcctttatag acttaatctg ctttttgtcc catttgacaa ggtaccagga ggaaattttt     2460

taagggatca actgtatcac agtgcccact ctggacctaa gtctagtgta tccatacaat     2520

tggtgcagag aaataaggtg taaatggtgc tttgttcctg ctggttccaa gctcagaaac     2580

caagactagc tttgtaggag agaatgagag cctgcaagcc tctctttgga ttggctgagg     2640

agtggtggga gcagggggtt gatagaaaac atccagacac acatataagc aagtggccgt     2700

gctacctttt tagagaataa agaaacagac ttttgagttt atatgcaatg ccttcattag     2760

gtaccaccgg cacttacaaa atgtgcggac tgaatcccag agaacactgg cagatgtata     2820

cagtatatgg attgtatcgc ttccccaatg tttgtaaatt cacagtattt ggaaaactgc     2880

cttcattttc cagtgtggga aaaactcttg ctacctgtat tacttgatct cagacccata     2940

cctgatggtt cagtctgtcc ttaagttaaa agaattttgc ttttctaatg ttatactatt     3000

tacctgtcag tgtattactg caacttgaat cactctttta ctgttgttgg atataaactt     3060

atcctgtacc aatgtattta ttaacacttg tattttatta ttgagcatat caataaaaat     3120

attaaaaaat aacagattgt tttttaccaa                                      3150


<210> 3063
<211> 3216
<212> DNA
<213> Homo sapiens

<400> 3063
tgaggggcga accaagatgg cggcggtttt ggctgtgtga ggaagacgga agagacggcg       60

gcggagggaa accgacttcc actagtccgg gtcgcttggg cggccggggg ccctcagagt      120

ctcccgggca gtggtagcag ttgcagcagg atcaggcgcc tgtcggcttc tgacgtttaa      180

aacaggggga gcggaaggga gccactggcc gcggtggcag ggccagggcc cctttcctgg      240

gcgtctactg gcggggcccc cgccccggtt cccgggcggc acgatgaccg acacccggcg      300

gcgggtgaag gtgtacacgc tcaacgagga ccggcagtgg gacgaccggg gcaccgggca      360

tgtgtcgtct ggctacgtgg agcggctgaa gggcatgtcc ctgcttgtca gggctgagag      420

cgacggttct ctacttttag agtcgaaaat aaatcctaac actgcatacc agaaacaaca      480

ggaagatgaa aaatttctga cagatttgtt tgcacaacta acagatgaag caacagatga      540

ggaaaaaaga caggaattgg ttaacttttt aaaagaattt tgtgcgtttt cccaaacgct      600

acagcctcaa aacagagatg cttttttcaa gactttgtca aacatgggca tattaccagc      660

tttagaagtc atccttggca tggatgatac acaggtgcga agtgctgcta ctgatatatt      720

ctcatacttg gttgaatata atccatccat ggtacgagag tttgtcatgc aggaggcaca      780

acagaatgat gatgtaagta agaagttaac agagcaaaaa ataaccagca aggatatttt      840

gctcatcaac ctcattatag aacatatgat ttgtgataca gatcctgaac ttggaggagc      900

agtccagctt atgggcctgc ttcgaacttt agttgaccca gagaacatgc tagccactgc      960

caataaaaca gaaaagactg aatttctggg tttcttctac aagcactgta tgcatgttct     1020

cactgctcct ttactagcaa atacaacaga agacaaacct agtaaagatg attttcagac     1080

tgcccaacta ttggcacttg tattggaatt gttaacattt tgtgtggagc accataccta     1140

ccacataaag aactacatta ttaataagga tatcctccgg agagtgctag ttcttatggc     1200

ctcgaagcat gctttcttgg cattatgtgc ccttcgtttt aaaagaaaga ttattggatt     1260

aaaagatgag ttttacaacc gctacataat gaaaagtttt ttgtttgaac cagtagtgaa     1320

agcatttctc aacaatggat cccgctacaa tctgatgaac tctgccataa tagagatgtt     1380

tgaatttatt agagtggaag atataaaatc attaactgct catgtaattg aaaattactg     1440

gaaagcactg gaagatgtag attatgtaca gacatttaaa ggattaaaac tgagatttga     1500

acaacaaaga gaaaggcaag ataatcccaa acttgacagt atgcgttcca ttttgaggaa     1560

tcacagatat cgaagagatg ccagaacact agaagatgaa gaagagatgt ggtttaacac     1620

agatgaagat gacatggaag atggagaagc tgtagtgtct ccatctgaca aaactaaaaa     1680

tgatgatgat attatggatc caataagtaa attcatggaa aggaagaaat taaaagaaag     1740

tgaggaaaag gaagtgcttc tgaaaacaaa cctttctgga cggcagagcc caagtttcaa     1800

gctttccctg tccagtggaa cgaagactaa cctcaccagc cagtcatcta caacaaatct     1860

gcctggttct ccgggatcac ctggatcccc aggatctcca ggctctcctg gatccgtacc     1920

taaaaataca tctcagacgg cagctattac tacaaaggga ggcctcgtgg gtctggtaga     1980

ttatcctgat gatgatgaag atgatgatga ggatgaagat aaggaagata cgttaccatt     2040

gtcaaagaaa gcaaaatttg attcataata atggcaacgg cctaggatca gtacctgttg     2100

aaaaaaactg gttctccacc cctcccccat acaaaatcca caacaaagcg cagtggtctc     2160

ttgtgaatga ctgacacaga tcagcctctt acacttgact tctgctcatc aagtgccaat     2220

tcaatggagc aggaggaggg gatatcatat atttagggga aagacttaag cctttgagct     2280

ctccagcttg gaccacacat tgcccttttc tcagggaagg aaatggaaac aaaaagccaa     2340

cagggcaggg gttttgtaag tggaactctg gattgactgg tcagttgcta caatcagaat     2400

atgctttctt ggaccatgtt tgagactcag aagaatgggc ctttctgcca taattcttca     2460

ctagtcaaga atgccagcag tttctttgta taaagagacc tgcctttaaa atcatacatt     2520

ctgaacattt tagtcaagct acaacaggtt tggaaaacct ctgtggggga ggggcgagta     2580

taaagttttc ctctttttta actgttccct ttgcccttca aactgcagat attttttttt     2640

ttaagtgggg acttctccct acttgattaa agattgagtg gaattctaga tgtggtcatt     2700

tgtgtcataa tttttttgtt ttattttgtt tttgattttt tttttcctcc cctgagtgta     2760

tgcttagttg ttgagtatat atatttggga ccattaaaac tttttttgat gtaatataac     2820

ctaacgttgt gctggtacct gttttaccat gtgtaatttt tgttctacat cacagttctt     2880

aatttgttta gagttttatg aaagatggta tagtttttat tgacaaaagc aaagtaatct     2940

tacaactatg tgcatacaaa agcaatacta ttttgtgact aaatatttta tattaaaatt     3000

tacatcagca actgtcttga gaattcaggg aaatagaatg gaatttaaaa cttcaacagt     3060

tttgttaaat ctagaaacat gaaattagta ttccaaagag attctgaaat ttcttttctt     3120

ggggaaatga cggtacatta aatcaaaatt gaggatggat gatttaaaaa catttgactt     3180

ttgaataata aaaagaaaag tgaagagtaa gagaaa                               3216


<210> 3064
<211> 854
<212> DNA
<213> Homo sapiens

<400> 3064
gaggcgtgag agagcgtgcc tgcccgccgc acacggggct ggtttccgga gtgcgtctct       60

agagggatgc acgttgcctt agccgagctt cggagagaag cctgatatgt aacccaggca      120

ggtgggagcc tcagtctgtc gggctgaggt ctggcatcta caaagcctct tggccgtgtt      180

ctgaacttga agcctggagg agttctctgc tcagcacagc caaggaacag aattagaaga      240

aaaggaaccc tggcctgagg taaagcggac attgcacaag gcaggtgaca aacattacca      300

ccccagctgt gcacgatgca gcagatgcaa ccagatgttc acagaaggag aggaaatgta      360

tcttcaaggc tccaccgttt ggcatcccga ctgtaagcaa tctacgaaga ccgaggaaaa      420

gctgcggcct accaggacat cctcggaaag tatttattct aggccaggct ccagtattcc      480

tggctcacca ggtcatacta tctatgcaaa agtagacaat gagatcctgg attacaagga      540

tttagcagcc attccgaagg tcaaggcaat ttatgacatt gaacgtccag atcttattac      600

ctatgagcct ttctacactt cgggctatga tgacaaacag gagagacaga gccttggaga      660

gtctccgagg actttgtctc ctactccatc agcagaaggg taccaggatg ttcgggatcg      720

gatgatccat cggtccacga gccagggctc catcaactcc cctgtgtaca gccgccacag      780

ctacactcca accacgtccc gctctcccca gcatttccac agacctgatc aaggaatcaa      840

catttaccga aagc                                                        854


<210> 3065
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 3065
gggagattac ggggcgggga cgagctgtcg cgctggttgc tcgtgcagga gcgggacccg       60

gaacagaccg ccgtgagaga ggaggggcgc cggccgggat tcgcggcccg gagctcggga      120

ccggttgctt cattccagcc tcgcagtcac ctctgtgccc tgctggttgt cttcccagcg      180

ctgctgtagt tgccttccat ggatctatag gagagcaagt cctccaggag aagaagtcct      240

caccagtgaa cggagacctc tctgaactaa ggataccatg gccacgtcag ccccactacg      300

gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac      360

cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg      420

gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt      480

gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca      540

gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa      600

gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg      660

ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa      720

aatcctgaac cacctgagta ccctaaggag agacagagac aaaattcagg gcttccaggc      780

aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat      840

tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga      900

acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg      960

cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca     1020

gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa     1080

gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga     1140

taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt     1200

ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct     1260

gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc     1320

ccagcagttt gactgtgagc ctggggtgct gggcagcaag ggcttcacct ggggcaaggt     1380

ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga     1440

ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga     1500

cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga     1560

ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag     1620

gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc     1680

cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag     1740

agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca     1800

ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct     1860

caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc     1920

caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc     1980

ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct ccccattgct     2040

gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt     2100

ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct     2160

ttcctttttg accacgacct tggccccagc tctgcactct ctggaataag ggcccgatgc     2220

agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc     2280

attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc     2340

ttctctggca ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa     2400

tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag     2460

cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc     2520

atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat     2580

ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga     2640

ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc     2700

aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc     2760

gggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact     2820

ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc     2880

ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa     2940

cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa     3000

ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa     3060

gttttaagtc ctccaccctg ttctaagaga ctgttccaac ggctctgggc ctcagtggtc     3120

acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca     3180

catgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta     3240

tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat     3300

aaagacttgt tgaatgaa                                                   3318


<210> 3066
<211> 2886
<212> DNA
<213> Homo sapiens

<400> 3066
gtcgcgagcc ggtggaggac ccgcgcgcgg aggagccggg gagtcagcgc ttcttccctc       60

cctccccctc tcccctcccc gctccctgcc cccctcccca agaatgttcc gctacgagtc      120

tttggaggat tgtcctctgg atgaagatga agatgcattt cagggactgg gagaagaaga      180

tgaagagatt gatcaattca atgatgatac atttgggtca ggtgcagttg atgatgattg      240

gcaggaagca catgagcgcc tggctgaatt ggaagaaaag ctaccagtgg cagttaatga      300

acaaacaggc aatggagaga gagatgaaat ggacttgttg ggtgaccatg aggagaatct      360

ggcagaaagg ctcagtaaga tggtgattga aaatgaacta gaagatccag ctattatgag      420

ggcagtgcag accaggccag ttttacaacc ccaaccagga agtctgaatt ccagtatctg      480

ggatggatct gaagttctga ggcgaatccg aggaccactg cttgctcagg aaatgcctac      540

agtgtctgta ttagaatatg ctttgcctca gaggcccccc cagggtccag aagatgatcg      600

ggacctttct gaacgagcat taccaaggcg gtcaacttca cctatcattg gcagtcctcc      660

tgttagagct gtccccatag gcaccccacc taaacagatg gctgtaccca gcttcaccca      720

acagattctg tgtccgaagc ctgtccatgt tcggccccca atgccacctc gttatcctgc      780

tccctatggt gagaggatgt ctccaaacca gctctgcagt gtcccgctac agcctggacg      840

gatgtctccc agccagtttg cacgggtccc tggatttgtt ggtagtccac ttgctgccat      900

gaatcccaag ttgctacaag ggcgagttgg gcagatgctt cccccagcac caggcttccg      960

tgccttcttt agtgctccac cctccgctac accacctcca cagcagcacc ctcctggccc     1020

aggaccccac ctgcaaaacc taagatctca ggccccaatg tttagaccgg acacaactca     1080

cctccatcca cagcaccgtc gactcttgca tcagagacag caacagaata gaagtcagca     1140

tcggaatctc aatggtgcgg gagatagagg aagtcaccgg agcagtcatc aagatcatct     1200

ccgaaaggat ccatatgcca atctcatgtt gcagcgggaa aaggattggg tctctaaaat     1260

ccagatgatg caactgcaaa gcactgatcc ctacctggat gatttttatt accagaatta     1320

ctttgaaaaa ctggagaaac tgtcagctgc tgaagaaata caaggtgatg gccctaagaa     1380

ggagcgcacc aagcttatca cccctcaggt ggccaaactg gagcacgcct ataagccagt     1440

gcaatttgag ggctctttgg gaaagcttac cgtttctagt gtgaataatc cccgaaaaat     1500

gattgatgct gttgtgacat ctcggagtga ggatgatgag acaaaagaaa aacaagttcg     1560

agacaagagg agaaaaaccc ttgttataat tgagaaaacc tacagcttac tccttgatgt     1620

ggaggactat gaaagacgtt atctcctaag tctggaagaa gagcgacctg ccctaatgga     1680

tgacagaaag cacaaaattt gtagcatgta tgacaactta agggggaaat tgcctggaca     1740

agagaggcct agtgatgacc actttgtaca gatcatgtgt atccgaaaag ggaagagaat     1800

ggttgcccgt attcttcctt tcctctccac agagcaagca gctgacattc tcatgacaac     1860

agccaggaac ctccctttcc ttatcaagaa ggatgcacaa gatgaggtgc tgccatgctt     1920

actgagtccc ttctctctcc ttctctatca tcttccatca gtgagtatca ccagcctttt     1980

gcgacagcta atgaacctac ctagttcaga ccctgctaca gaatcaacac aaaataatca     2040

gtggacggag gtgatgttca tggcaacacg agaacttctg cggattcccc aagcagccct     2100

ggccaagcca atctctatac ctacaaacct agtgtccctc ttttctcgct atgttgaccg     2160

gcagaaactg aacttgctgg agacaaaact gcagctagtt caggggatac gataaaagat     2220

ctccaaatgt gtcctgtacc tccttttggc tgccacctgc actgctgcca tcaccaatgg     2280

agtgttttta atgagggaag gaaggtagct ttttccccaa agcaaagtct tgtgggatcg     2340

attcctgttt acaggggttg tctctctaaa tgtcagatat ttccccactg ctctatgaaa     2400

tttggctggg tgatacttct gctggtttct ttaccttctg tgttacagtt ctgcatgtcc     2460

tacttttact cagttctgtt ttgcattttc tttgccctag agacacaagt gtaatctctc     2520

cctttatccc tccactactc cacctcagag tagattgtag cctgccaaag gattccttcc     2580

ctcatcctat tgaagttgtt ttttcattgc cccatattaa tatgactata gaagagccaa     2640

ttaagtagaa atcaagatat acacacacac atagatacac acacacacac cccatacatg     2700

tatttatgtg gtcttcagag ggtccttaaa gaatgaattt tagattgaaa aatatttagt     2760

tgtctcatta cctcttctaa acacaaacca gctgatgtat tttaatctgt ttctgttcta     2820

tcttgtaatt aatttggtgg gttctacttg ttttaacata aataaagagt atgcagcacg     2880

tttaat                                                                2886


<210> 3067
<211> 1709
<212> DNA
<213> Homo sapiens

<400> 3067
ggtacctcgt ggagaagacg ggggagggga gcagcgagat ttccttgcgg agcaatattc       60

ctagggtaca gacctcgtag cccgggcccg cgactccgcc ccgggagcgg gcaggggcgg      120

ggcgagcgct ccagctggcg ggaaggagga agggccgggc gcggcgcaga ggcgggcgcc      180

taccagccgg cagctccgga gctgcccgcg ccatgtccgc gcacaatcgg ggcaccgagc      240

tcgaccttag ctggatctcc aaaatacaag tgaatcaccc ggcagttctg aggcgtgcgg      300

aacaaatcca ggctcgcaga accgtgaaaa aggagtggca ggctgcttgg ctcctgaaag      360

ctgttacctt tatagatctt actacacttt caggtgatga tacatcttcc aacattcaaa      420

ggctctgtta taaagccaaa tacccaatcc gggaagatct cttaaaagct ttaaatatgc      480

atgataaagg cattactaca gccgccgttt gtgtttatcc cgcccgggtg tgtgatgctg      540

taaaagcact caaggctgca ggctgtaata tccctgtggc atcagtggcc gctggatttc      600

cagctggaca gactcatttg aagacacgat tagaagagat cagattggct gtggaagatg      660

gagctacaga aatcgacgtg gtaattaaca gaagcttggt gctgacaggc cagtgggaag      720

ccctgtatga tgagattcgt cagtttcgca aggcctgtgg ggaggctcat cttaaaacta      780

tattagcgac aggagaactt ggaactctta ctaatgtcta taaagccagt atgatagcaa      840

tgatggcagg atcagatttt attaagacct ctactggaaa agaaacagta aatgccacct      900

tcccggtagc tatagtaatg ctgcgggcca ttagagattt cttctggaaa actggaaaca      960

agatagggtt taaaccagca ggaggcatcc gcagtgcaaa ggattccctt gcttggctct     1020

ctcttgtaaa ggaggagctt ggagatgagt ggctgaagcc agaactcttt cgaataggtg     1080

ccagtactct gctctcggac attgagaggc agatttacca tcatgtgact ggaagatatg     1140

cagcttatca tgatcttcca atgtcttaaa tcagtcacca gttccagaaa agttctttac     1200

gacaatgttt aaaaattatt tttctacgta attgctaaaa ttatttaatt aaaaaattgg     1260

gcagtaggta actggcattc ctctctttaa aatttctacc gaacttaatg gaatggaaaa     1320

agcaaactca tccacatgtg gtactcattt caggcacatc tgaaatgatc ttaattacta     1380

gaagatctgc actattaact ttgtgaagag tttctcctaa aaactttaag taaaatgtta     1440

atggtagctt tgataacatc aaattctaag ggagaaaaaa acaatattaa accgcccaag     1500

cagtgtgccc tagcagagga aaatgcaaca tctcgcaagc gctgctgtaa cgacttcagg     1560

agtcactgat tcagcactaa tttcctgctg tgaaaactca tctttcattt ttgccgtgga     1620

taggcgcttt tattaattgt tgtcctaatg aaatttctga cattgtcata tacaacgatg     1680

aatatcatta aaatttttaa aataataaa                                       1709


<210> 3068
<211> 3010
<212> DNA
<213> Homo sapiens

<400> 3068
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg tggatggcca gggtacctgg     1200

ggactcaggc tgctgccagt tctgctcacc accatccgtg cttggcacag aagtagctgc     1260

atagaaagag cactggattt gaagtcagaa gacctgggtt cttgaaccag cctgtcaacc     1320

agttgtatga ctttaaacaa ggcatctcac ctcttttcat cttgttttct tccaataatg     1380

ttagagttca tgtaatcaca ttctctagaa ccatttagtt tgtgttaact atgaaccaag     1440

cagtgtggtg gccactggtg acttgaaaat gtagagaaaa aaaaaacctg ctctatatct     1500

gaaagagctc ttgggaagac agagaaacat aaagaggaaa ttatagcaca gtgtggtggg     1560

tgttacggga agtccaaccc cagcattatg ggagttcagg ggaaggggca tagcccagcc     1620

tggaaggaga ggatgagtgg gggatggctt tctgaaaagg gtagtctaaa ggatgcctat     1680

agtcaatagg gaaaagaggg gaagaagcat cttaagaaga ggaaacagca gagaactggc     1740

tggatgacct gtgactctgg agcactgggt tgtctccatt gtccttatgg gcagatgtgt     1800

gccatcccca gccgacacca ctcactgcct ccttcctcct ggtgttgcca cttctgggtg     1860

agattaaggt gcagggcctg ggggcaggag gacataaggt atagccataa atcataaccc     1920

agggaccaca ctcaacccta gggaaattgt cttcctgatc agttgattac catctgaggt     1980

caagaaatga gatagtggga gcaaatgggt cacaaatagc tcagctgtgg gctcagaaac     2040

tgctaggtaa aagaattcca gaaggaggcc agggcataag ttggatgacc tatgaccttt     2100

agtctaaaga attgagacta ccgtaattga gactactgta gtgacatctg agaaatggga     2160

tggaagagtg accatgtttt attttcttgt tcttgtcact attgtatttt attttgcata     2220

atcatgccct tcactgacag tctccttaac atcatctgtt tactctgctc agatgtaaaa     2280

tacaatgctc tgtcatctcc ctactgggtc tcctgggagg aggggagcca tccagggtgc     2340

aaactcaaag gcagagggca cagcgtgctt aggcccaagc ttagaattca attgagaagt     2400

tctgttgttc atccttacct cagcaggtag aaaagaggtg gagatcagaa gccagggatt     2460

aaagattgaa ttgctttccc tgggagtgtg cagtatctca ttaaaatgtt gtatattcaa     2520

aaaaatacag acacacacaa gtgcctatat aatgataaaa catatgcaaa gcacccaaac     2580

ctgtgattcc agaaaggtag atcctatttt tctgtttatt tttattggct ttagctgtgt     2640

cttttgaaag gactattatc ctctaaaatg tatgtgtatg aagatcctgg cttgcagctc     2700

gggagcttta cacaccttgt gtcactttat cttggtaacg agccaagatc atgcaaccag     2760

ttcatccatg tctgacccaa gagctcttaa ctgctatgct gcactgcctc attcagagat     2820

agatgcctgc atgggtcctg gcgattattt taatgctggc tacaccccca caggtgactt     2880

ggattcagaa atacaattta tatttcttct ttttaaattg ttttatttta tttttctttt     2940

aatagttata tgtcagtgag aacaatttat atgtcttaca ctgagaaata aaactgctca     3000

taagtgaaaa                                                            3010


<210> 3069
<211> 5125
<212> DNA
<213> Homo sapiens

<400> 3069
atcgggccgc cggcgtccgg gctccagagg ccgcctggct gggcgcccgg tgccttttgt       60

ctggcgcagg gccggcgttt gcatcacatt tcggatacct ccctctcttt ttcgcctctc      120

cttctgcctc ccgctcacat cgcctcccca ctcccgccac cgtcccccgc cggactgcta      180

gcctcctaga ccgaagcccg aggacgtctc tgcccgagcg atgtcccctc tccagaaagt      240

tgccgccgcc gccgccgccg ccgccactgc cgccgctggg cggtgaaaca aagtctggcg      300

gggccgcctc ccggtgcagg agcgcaccgg tgcctagcgg ctggactccg ctgccgggcg      360

tcccgctttc ccccggggag ccctaaacgc tccaggccat ggccgagggc gcggccggca      420

gggaggatcc ggcgccgccc gacgcggcgg ggggcgaaga cgacccccga gtgggcccgg      480

atgccgccgg ggactgcgtg acggcggcct ctgggggccg gatgagggac cgtcgcagcg      540

gggtcgcact gccaggcgcc gcggggaccc cagcggacag cgaggcgggc ctcctggagg      600

cagcacgggc gaccccccgg cgcagcagca tcatcaagga tccttcaaac caaaaatgtg      660

gtggaagaaa gaaaaccgtg tctttcagca gcatgccatc ggaaaagaaa attagcagtg      720

caaatgactg catcagcttc atgcaagctg gctgtgagtt gaagaaagtc cggccaaatt      780

ctcgcattta caaccgtttt ttcactctgg acacagacct tcaagctctt cgctgggaac      840

cttcaaagaa agacctcgag aaagccaagc ttgatatttc tgccataaaa gagatcagac      900

tggggaaaaa cacggaaaca tttagaaaca atggccttgc tgaccagatc tgtgaggact      960

gtgccttttc catactccac ggggaaaact atgagtctct ggacctagtt gccaattcag     1020

cagatgtggc aaacatctgg gtgtctgggt tacggtacct ggtttctcga agtaagcagc     1080

ctcttgattt tatggagggc aaccagaaca caccacggtt catgtggttg aaaacagtgt     1140

ttgaagcagc agatgttgat gggaatggga ttatgttgga agacacctct gtagagttaa     1200

taaaacaact caaccctact ctgaaggaag ccaagatcag gttaaagttt aaagaaatcc     1260

agaagagcaa ggaaaaacta accacccgcg tgaccgaaga ggaattttgt gaagcttttt     1320

gtgaactttg caccaggcca gaagtgtatt tcttacttgt acagatatct aaaaacaaag     1380

aatatttgga tgccaatgat ctcatgctct ttttagaagc tgagcaagga gtcacccata     1440

tcaccgagga tatatgctta gacatcataa ggagatacga actttctgaa gagggacgtc     1500

aaaaagggtt tcttgcaatt gatggcttta cccagtattt attgtcatca gaatgtgaca     1560

tttttgatcc tgagcaaaag aaggttgccc aagatatgac ccagccatta tctcactact     1620

atatcaatgc ctctcataac acctatctaa tagaagacca gttcaggggg ccagctgaca     1680

tcaatgggta cattagagct ttgaaaatgg gctgtcgaag cgttgaactc gatgtaagtg     1740

atggttcaga taatgaacca atcctttgta atcgaaataa catgacaacc catgtttcct     1800

ttcgaagtgt catagaggta ataaataaat ttgcctttgt tgcttctgaa tacccactca     1860

ttctttgctt gggaaatcac tgctccttgc cgcagcagaa ggtaatggct caacagatga     1920

aaaaggtctt tggcaataaa ctctatactg aagcaccttt gccctcagaa tcctacctcc     1980

catcaccaga aaaattaaaa agaatgatca ttgtgaaagg aaagaagttg ccttctgatc     2040

cagatgtgtt agaaggagaa gtaacagatg aagatgaaga agctgaaatg tctcgaagga     2100

tgtcggtaga ttacaatggt gagcagaagc aaatccgact ctgtagggag ctctctgatt     2160

tggtgtctat ttgtaaatct gttcaataca gggattttga actatctatg aaaagccaaa     2220

actattggga aatgtgttca tttagtgaaa cagaggccag ccgcattgca aatgagtacc     2280

cagaggattt tgttaattat aataagaagt tcttatcaag aatctatcca agtgccatga     2340

ggatcgattc cagtaacttg aatccacagg acttttggaa ttgtggctgt cagattgtag     2400

caatgaattt tcagactccg ggtccaatga tggaccttca cacgggctgg tttcttcaaa     2460

acgggggatg tggttatgtt ctaaggccgt ctataatgcg agatgaagtt tcttacttca     2520

gcgcaaatac aaagggcatt ctacctgggg tgtctcctct agctcttcat atcaagatca     2580

tcagtggtca gaatttccca aagcccaagg gagcttgtgc caaaggggat gtcatagatc     2640

cctatgtttg tatagagata cacggaattc cagcggattg ttcggaacaa agaactaaaa     2700

ctgtacagca aaacagtgat aatcctattt ttgatgaaac ttttgagttc caagtaaacc     2760

tacctgagct ggccatgatc cgttttgttg ttctggatga tgactacatt ggggatgagt     2820

ttatagggca atatacgata ccatttgaat gtttgcagcc tggatatcgg catgttcccc     2880

tgcgttcttt tgtgggtgac atcatggagc acgtaaccct ttttgtccac atagcaataa     2940

ctaatcgaag tggaggagga aaggcacaga agcgcagtct ttcagtgaga atggggaaga     3000

aagttcggga atataccatg ctcaggaata tcggtcttaa aaccattgat gacatcttta     3060

aaatagcggt tcatccatta cgagaagcca tagatatgag agaaaatatg cagaatgcaa     3120

tcgtgtctat taaggaacta tgtggactcc ctccaattgc cagtctgaag cagtgcctgt     3180

taactctgtc atctcggctc atcaccagtg acaatactcc ttcagtctca cttgtgatga     3240

aagacagctt tccttacctg gagcctctgg gtgcaattcc agatgtgcag aaaaagatgc     3300

tgactgctta tgatctgatg attcaagaga gccggtttct catagaaatg gcggacacag     3360

tccaggaaaa gattgtacag tgtcagaaag cagggatgga gttccatgaa gaacttcata     3420

atttgggggc aaaagaaggc ttgaagggaa gaaaactcaa caaagcaact gagagctttg     3480

cttggaacat tacagtattg aagggccaag gagatctgtt gaagaatgcc aagaatgaag     3540

ctatagaaaa catgaagcag atccagctgg catgcctgtc ctgtggactg agtaaagccc     3600

ccagcagcag tgctgaggcc aagagcaagc gcagcctgga agccatagag gagaaggaaa     3660

gtagtgagga gaatgggaag ctgtgactct gggcattatc gacacgttca cccatcttat     3720

caaggactct ggtttctcat tcttgttttc tttctttaaa tgttttataa gttcacaaaa     3780

tggtgcccta tatggggtat tggacataga tattttcaca atgtcagtat ttcagtgtag     3840

ttaatttatc taaattaaag cctttagtat cagtgtttta aattctgaga catgtgtcaa     3900

cacccctgtg tggatgcctg tggaagagtg tgtgtgtgtg tgtgtgtgtg tgtgtgtggc     3960

agagagagag aaagagagag agagagagaa attctgttaa aatctattct gtgttgcatt     4020

attcatttag tgagttattc cttgatcatt ttgggacaat tgttttaatc tgaaattcta     4080

aagagcactt actgtaacct gttgctgtgt ttaatttgac ttctctgcct ttgacattta     4140

atttagtgat cttagcatag cttattattg aaggaagcca aatttatcaa agcatagatg     4200

ttttggtaga ttaaatatag attagaaaaa ttcctaagaa tcagagtaga aataaaagtg     4260

aatgaaagat taaacagatg atgagaattt ctaaaaagat tagcaaggtc atttcttcag     4320

tcagaaaact ttaaaaaata tttattaaat aaaatcaatt tttaggaagt tttctgtagt     4380

catttactaa acatatgatt tcactagaaa agctgatcat aagtgaattt atacctacct     4440

gtgtggtact ctgaaacaca ctgaaagctc tgttgcaatt aggattttga tgtgacaata     4500

atattgttgt ataatttcga gatttgtagg aaggtctcat tcttccaagc tgagagtcta     4560

gcactcattt tctataacag atatggcagc ttagaggtgt tggctttgtt tggatgtaat     4620

ttagggtact aaatttaaat ttaaagatat tgttcaaaca atatcatatc atcacattga     4680

gctgatataa attctgtggg tccgataata tctttgtgat aatttaagag ctaaccagtt     4740

accacacatc tatgatataa ccctaacaca cacagaaaag catacatgca aaaagaaatg     4800

actaattagg gtacatttat aattgcatct aggtaatttt taccctaatg tcttcataaa     4860

gtacttgagt gtaatgtttg ttacctccaa cagaactaaa tgttctatgg ttatgaaaga     4920

atatatttat ttaaagcatt gcttttattt tgaaaagctt cttaattaat ttgattaaca     4980

aatatgctaa tttggggaaa cctagagaag ataattgttg aaattttgca aatataaaca     5040

tctcctatag cttctgtgtt atttctgact tcttaacact attatgttta tgttgcacat     5100

tactgaaaga gtaaagatat gaaaa                                           5125


<210> 3070
<211> 876
<212> DNA
<213> Homo sapiens

<400> 3070
aaagagcccg ctccgccgag cgccgggcga cggcaggaag cccctccgct tggccagaat       60

ggagcagccg aagggagttg attggacagt catcatcctg acctgccagt acaaggacag      120

tgtccaggtc tttcagagag aactggaagt gcggcagaag cgggagcaga tccctgctgg      180

gacgctgtta ctggccgtgg aggacccaga gaagcgtgtg ggcagcggag gagccaccct      240

caacgccctg ctggtggctg ctgaacacct gagtgcccgg gcaggcttca ctggtcgaga      300

cttccccttt gatgactgtg gcagggcttt cacctgcctc cccgtggaga accccgaggc      360

ccccgtggaa gccttggtct gcaacctgga ctgcctgctg gacatcatga cctatcggct      420

gggcccgggc tccccgccag gcgtgtgggt ctgcagcacc gacatgctgc tgtctgttcc      480

tgcaaatcct ggtgagcctg agactacctg ggactgcctt ccttcgtcac agccacagca      540

agaagccagc tctgcccttc ttgcccaccc tgcctctggg cctgccccgc tgccctatta      600

gacgggaagc tggagggtgt ggagaatgaa gcctggtgga ggcagggctt ctcctgctgt      660

gcctcagtct gtctgtctat aggatggaca gaagcagccc tgccccttct gtcccacagg      720

gctctgcgga agaactttgg gagaggaggg ttgtcattct cccaggcgaa tgtccatttg      780

gcttggaaac cgtatttccc ttttagaggt gcccaggtgc cgcagccctg ggctcttgct      840

tccacctggt ggggaaatcc gtgccttggg tggagg                                876


<210> 3071
<211> 2911
<212> DNA
<213> Homo sapiens

<400> 3071
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc       60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccagagc acaaagttat      120

cattgttggg ctggataatg cagggaaaac taccattctt taccaatttt ctatgaatga      180

agttgtacat acatctccta caataggaag taatgtagaa gagatagtga ttaataatac      240

acgtttccta atgtgggata ttggtggcca agaatctctt cgttcttcct ggaacactta      300

ctatactaac acagagtttg taatagttgt tgtggacagt acagacagag agaggatttc      360

tgtaactaga gaagaactct ataaaatgtt agcgcatgag gacctaagaa aagctggatt      420

gctgattttt gctaataaac aagatgttaa agaatgcatg actgtagcag aaatctccca      480

gtttttgaag ctaacttcta ttaaagatca ccagtggcat atccaggcat gctgtgctct      540

aactggcgag ggattgtgcc aaggacttga atggatgatg tcacgactta agattagatg      600

atctctactg acctcttctc atagattttg tataaatgaa gtgctggact ttacctgaaa      660

gctgcaaaaa ttaatggttt agatatattt ataataaact gatttaaact ttttctataa      720

gaagaaaaat taagaccact tatttgaaaa caaagatgaa gtctcacctt ccagtttgct      780

ttctcattag ttttttccaa agtaagttat tgaagctgtg attgacattt ttctcataat      840

gaatcctctc aggacattgt gtagcctatg gtaagtacaa agggagagga agacattttg      900

aattttaaga gctttattat cagtttaacc ctccctagtt gaatgttatt ttcttcttgt      960

tccattaagt cagaatacaa atcagcacag atattcgaat gtttccaata ttttaaaatg     1020

taatgttact tatgaaaagt attttgctta aggttgtgtg tgtattgtgt atatacctca     1080

agttcaagtt aatggcattg atttatgttc cagacaaaaa taacacaaat aataatatcc     1140

ttcgttataa ccacaatgag ataagtattg gcattagtgt tcagtgccat tttatacttt     1200

ctctctgtgt tctctgtatt gtactaacca acctcccaaa tcgctgagct gcttgtttaa     1260

aaaaaaaaaa aaggaaaagg aaaaagcatg acattgtgta tcgatttttt gttgttgacc     1320

aaaatcacac acatggaaac atgtaattca acagagtggg aaagctagca gattcttggc     1380

ttagtattac taataggcag gattgtacaa tgagcaacta tcagattatt cctttcagtg     1440

gttcttatgg catctaaatt actgaataaa ttattaatcc attaatcagt gaatcaaatt     1500

atgattacaa ttatcaaatg aatgctcagc attaattgaa aactgttttg tgaaacatgt     1560

ctacccagaa aagtagcatt ctataaatac tattaaacaa cttagctata ttatttttaa     1620

gtattaaatt atatgtcaag cagttaaagt gaatttcaga gtaaaagtaa ggcatgtttc     1680

tgagcaacat tgataatttc ttaatttgca aatttcttct tattttggta cttggaatat     1740

agtgtgagat tttttatttc taaattttgt tgtatcttct attacataaa tgcattgaca     1800

attataaaat gcaagtgttt tttgaatgat tttaagaatt tggcttaaaa attgattgat     1860

acaacgtatt atttgtacta agaagtaact tgacccaaaa caccttttat gtttgcttag     1920

ggtatatttt ttcagtgtct gaaagtcaaa ggtattcctg tcacaactgt aaacaaactt     1980

atcctaaatg tgttaaaaca tattcttggg tactctattt atgtatcttt catgccttga     2040

aaatctgaag gttaatccaa actcacatgt tttagcatat ttgagaaaaa aaaactacct     2100

tcaatatcag ccttttaaat ttcatgaaga ttttggtgag gaataatagt atatagttta     2160

agtattgaca aaactttgaa agtttctttc tttaaaatgg gaaatactca atatctaaat     2220

ccaggtcagg catgggatat cagtatttaa cattggatgt tttatgtttt atatttataa     2280

tgttcaaaat gcaagcataa catttaatat ttgtccacat ggttttacaa aagtaaatct     2340

taaattacta agcttttccc atatgttctc gtactttctc aaatccctat aaagaattac     2400

ttgttatcta ttaaaaatct cctttaccca aatctgtatt atggtttcgc cagacaaata     2460

ttatgtgatg tagcccagaa aatccacacc ttttgtcctt tttatgtttt aatttgaata     2520

atcatgtgct tagtcccttg gattactgcc acatcagttt aacacgatat cagcacattc     2580

ccttgtcatc atcaaggtgt tggctcagat ttattcttaa ttggatgttt aaagcatgta     2640

ctaccttgtt acagttggtt tagtgtagtg gattattgac atgacatcat gagaagatgt     2700

gtaattttat accacattta taaaacatga ttttgttttc tacccttcaa ggtaaacatt     2760

aaaaataagg tggtacttgt gtacttgtac ataaaaccaa aattatagtt gggaaaaaaa     2820

taaatttata tatgaaaatg tcaaaatcat tttaaaagta ttattttcaa ataaaatgga     2880

gaagctggtg aaaagtcata ttggcaattt t                                    2911


<210> 3072
<211> 2101
<212> DNA
<213> Homo sapiens

<400> 3072
cctgggcatg cgcgagcgcg tcccgggccc ggcgagtcga gggttcaggt ggtgcgccgt       60

ggcgccgcct gcgaccggca gctcgttcgc cgcactttgg aggcttcggc tgcccctccg      120

acccacgtag ggcccggacc cgggcctcct tgtgaacagc gtgccggctt cgccccacgg      180

gttcaccggc tggctgggct tcaagcgccg aggccgccgc agtgaccccg cccccgggcc      240

gaggatgtga ggcgggccgg gcgtccccac accgggcccg ggcgccggga gtgggcgtct      300

gggcagcgcc aggcgatggc cctgctgctg gtgctcctcg cctcttgggg cctggggcag      360

tgagggggcc ggcgggcgtg ggccgagtgg ccgcgggcgc catggagggg gtgctgtaca      420

agtggaccaa ctatctgagc ggttggcagc ctcgatggtt ccttctctgt gggggaatat      480

tgtcctatta tgattctcct gaagatgcct ggaaaggttg caaagggagc atacaaatgg      540

cagtctgtga aattcaagtt cattctgtag ataatacacg catggacctg ataatccctg      600

gggaacagta tttctacctg aaggccagaa gtgtggctga aagacagcgg tggctggtgg      660

ccctgggatc agccaaggct tgcctgactg acagtaggac ccagaaggag aaaggcaatt      720

tgctgaaaac actgaaaact tgaaaaccaa aatgtcagaa ctaagactct actgtgacct      780

ccttgttcag caagtagata aaacaaaaga agtgaccaca actggtgtgt ccaattctga      840

ggagggaatt gatgtgggaa ctttgctgaa atcaacctgt aatacttttc tgaagacctt      900

ggaagaatgc atgcagatcg caaatgcagc cttcacctct gagctgctct accgcactcc      960

accaggatca cctcagctgg ccatgctcaa gtccagcaag atgaaacatc ctattatacc     1020

aattcataat tcattggaaa ggcaaatgga gttgagcact tgtgaaaatg gatctttaaa     1080

tatggaaata aatggtgagg aagaaatcct aatgaaaaat aagaattcct tatatttgaa     1140

atctgcagag atagactgca gcatatcaag tgaggaaaat acagatgata atataacagt     1200

ccaaggtgaa ataaggaagg aagatggaat ggaaaacctg aaaaatcatg acaataactt     1260

gactcagtct ggatcagact caagttgctc tccggaatgc ctctgggagg aaggcaaaga     1320

agttatccca actttcttta gtaccatgaa cacaagcttt agtgacattg aacttctgga     1380

agacagtggc attcccacag aagcattctt ggcatcatgt tatgctgtgg ttccagtatt     1440

agacaaactt ggccctacag tgtttgctcc tgttaagatg gatcttgttg gaaatattaa     1500

gaaagtaaat cagaagtata taaccaacaa agaagagttt accactctcc agaagatagt     1560

gctgcacgaa gtggaggcgg atgtagccca ggttaggaac tcagcgactg aagccctctt     1620

gtggctgaag agaggtctca aatttttgaa gggatttttg acagaagtga aaaatgggga     1680

gaaggatatc cagacagccc taaataatgc atatggtaaa acattgcggc aacaccatgg     1740

ctgggtagtt cgaggggttt ttgcgggaca cacaaatgtc tgatggtggc ccaggagggc     1800

tgtcactcag aatcaggcgg gtgcagagtg gcctgcagga catgatgacc cagcatgaga     1860

caggatgcat cacatctggg tgacgcctct ctccagggga tcagcctgga ctaaatgcct     1920

ctcctgggcc aggatgccca gcaagccccg agatgcctcc tggagagaag gaagtatgtg     1980

agagtatcct gagttaagtg agatctaaaa tgcctgagaa aaccctgaaa tgactgagtc     2040

tatctggaac ttatttgatt gtttttctgc catcagatag aatgaggtct caaaagagaa     2100

a                                                                     2101


<210> 3073
<211> 1462
<212> DNA
<213> Homo sapiens

<400> 3073
gcgagccggg caactgccct ccttccgcgc cggcggagcg attaaagtga agaaacaatg       60

gccagcaatc acaaatcttc agcagctcgc cctgtttcaa gaggtggagt tgggttaaca      120

ggaaggcctc cttctgggat acgaccccta tcaggaaata ttcgagtggc aactgcaatg      180

ccacctggga cagcaagacc aggttctcgt ggttgtccca tagggactgg tggagttctg      240

tcttctcaaa tcaaagttgc ccatcgccct gtaacacaac aaggtttgac tggaatgaaa      300

actgggacga aaggtcccca gaggcaaatt ttagacaaat cttactatct tgggcttctt      360

agaagtaaaa taagtgaact tacaactgaa gttaataaac ttcagaaggg aatagaaatg      420

tacaatcaag agaattcagt atatttgtca tatgaaaaga gggctgagac tttagctgtt      480

gagataaaag agcttcaagg acaactagca gactacaaca tgttggtaga taaacttaat      540

accaacactg aaatggaaga agtaatgaat gattacaata tgcttaaagc tcaaaatgat      600

cgagaaacac aaagtttgga tgtcatattt actgaaagac aagcgaaaga aaaacaaatc      660

agaagtgtcg aagaagaaat tgaacaggaa aaacaagcaa cagatgacat tatcaaaaat      720

atgtcttttg aaaaccaagt caagtaccta gagatgaaaa ccacaaatga gaaactgtta      780

caggaattag atacacttca acaacaattg gattcacaga acatgaaaaa agagagcctg      840

gaagcagaaa tagctcactc ccaggtgaaa caggaggcgg tattgctgca tgaaaaactt      900

tatgagttgg agtcccatcg agatcaaatg attgcagaag acaaaagcat aggatctcca      960

atggaagaga gagagaaatt acttaagcag attaaagatg ataatcagga aatagccagc     1020

atggaaagac agttaacaga tacaaaagaa aagataaatc agtttattga agaaattaga     1080

caacttgaca tggatttaga ggaacaccaa gatcctacca actatggatg gaaaatactt     1140

gaaaaaaata caggaagttt caaaaagcaa gtttgaacct gccatgtgct aagcactatg     1200

ctgaatccat ttgaactgaa gaataccctg ctatagcctc ccattgtttc acagatcttc     1260

agtctctctc tagcacccac tgtttgagca gtgttcatct ggcattttat tcattggcta     1320

cttgtgttca ctctttgctt ctgtgaaaaa aaaaagactc ctaaaaatca attatatggt     1380

gaaagaaatc ccttacagac taagagagag cgtaaagtgc tgtctctcaa caagaaaata     1440

aaattcttag atcttttgaa aa                                              1462


<210> 3074
<211> 506
<212> DNA
<213> Homo sapiens

<400> 3074
ttcgtgaccc ggagctgtgc gaggagagta ccgaggaggg ggactcaaga gtagccttcc       60

tcgaggacct gcctttccca tttgctgcct gaagttaatg tttcttgctg gccaaatcag      120

ggacatgccg gcattagcgg gatgagtggg tgttccggca gggatgtggt cattgacggc      180

cagtgagggc gagagtacca cggcccactt cttccttgga gctggagatg aggggctggg      240

cacccgtgga ataggcatga ggccagaaga gagtgacagc gagctccttg aggatgagga      300

ggatgaagtg cctcctgaac ctcagatcat tgttggcatc tgtgccatga ccaagaaatc      360

caagtccaag ccaatgactc aaatcctaga gcgactctgc agatttgact acctgactgt      420

tgtcattctg ggagaagatg taatccttaa tgaacctgtg gaaaactggc catcctgcca      480

ctgcctcatc tctttccact ccaaag                                           506


<210> 3075
<211> 539
<212> DNA
<213> Homo sapiens

<400> 3075
cttttcaagc aaagccccat ctcgccgtgc tcacaggact actgtcatag gaacatggat       60

gaaacttcca attgaagaca ctgagctgaa ccattccgcc cgcccgcccg cccgagggca      120

ctccagatct gccggaggcg ctgggcaatg accccgggac tccaggccag aggggtctga      180

agctgtttgg gaaagcagcg ggactccttg ggaagatggc catggcccca agcccttccc      240

tggtgcaggt gtacaccagc cccgcggctg tggccgtgtg ggaatggcag gacgggctgg      300

gcacctggca cccctacagt gccaccgtct gcagcttcat cgagcagcag tttgtccagc      360

agaagggcca acgttttggg cttgggagcc tggcccacag catccccttg ggccaggcag      420

acccctcgct ggccccttac attattgacc tccccagctg gacccagttc cgccaggaca      480

ccggcaccat gcgggctgtg cggagacacc tgttccccca gcactcagcc cctggccga       539


<210> 3076
<211> 644
<212> DNA
<213> Homo sapiens

<400> 3076
agtgcgttac ttacctcgac tcttagcttg tcggggacgg taaccgggac ccggtgtctg       60

ctcctgtcgc cttcgcctcc taatccctag ccactatgcg tgagtgcatc tccatccacg      120

ttggccaggc tggtgtccag attggcaatg cctgctggga gctctactgc ctggaacacg      180

gcatccagcc cgatggccag atgccaagtg acaagaccat tgggggagga gatgactcct      240

tcaacacctt cttcagtgag acgggcgctg gcaagcacgt gccccgggct gtgtttgtag      300

acttggaacc cacagtcatt gattggtgcc ccactggctt caaggttggc atcaactacc      360

agcctcccac tgtggtgcct ggtggagacc tggccaaggt acagagagct gtgtgcatgc      420

tgagcaacac cacagccatt gctgaggcct gggctcgcct ggaccacaag tttgacctga      480

tgtatgccaa gcgtgccttt gttcactggt acgtgggtga ggggatggag gaaggcgagt      540

tttcagaggc ccgtgaagat atggctgccc ttgagaagga ttatgaggag gttggtgtgg      600

attctgttga aggagagggt gaggaagaag gagaggaata ctaa                       644


<210> 3077
<211> 1476
<212> DNA
<213> Homo sapiens

<400> 3077
gaaagagcag aagaggaggt ggggtggagg gagcagagcc agggattagg ggactactga       60

ggctctggag atgagaccgc caggagtcct tccccaccat gagccccctc cactcctgca      120

gctggaggag tttttcccag tctcagtgct gccctggggc gagagagact gaacaagctg      180

tttgggtggg aagagaatgg aggaagttga cagggatggg cggggcccgt gggggggctg      240

accaggaacc cagcttcctg ctcagtaccc aggcatccag cccccagctc acccccaccc      300

cttccagccc ccactcccct caggaaccca aggttccagc cctcctccca aatcccagcc      360

acccctcccc caccagtttc tcccctctag gggatggagg ctgagagacc ccaggaagaa      420

gaggatggtg agcagggccc ccctcaggat gaggaaggct ggccccctcc aaactccacc      480

actcggcctt ggcgatctgc tcctccatcc cctcctcctc cagggacccg ccacacagcc      540

ctgggacccc gctcggcctc cctgctctcc ctgcagactg aactccttct ggacctggtg      600

gctgaagccc agtcccgccg cctggaggag cagagggcca ccttctacac cccccaaaac      660

ccctcaagcc tagcccctgc cccactccgt cctctcgagg acagagaaca gctttacagc      720

actatcctca gtcaccagtg ccagcggatg gaagcccagc ggtcagagcc tcccctccct      780

ccaggggggc aagagctcct ggagttgctg ctgagagttc agggtggggg tcgaatggag      840

gagcaaaggt cccggccccc cacacacacc tgctgagact tgagccccaa ccagcccttc      900

cttgccactg gtctcaaagc tgggcagccc attgcatgcc ctcaactctt gcttggcagg      960

ggtaccagag actgaaagac acggcacaaa tctcaatatt catctcccac atcaccttcc     1020

ctgggaactg gacagggtga aagtcctcaa actctgggaa caggcgagat ggaacaggga     1080

tttaactccc cgcccacagg tccatgggag cttgaggcag taagggggat cccaggcacc     1140

catctcaagg agtggctggg agtcttttcc ctaacttgtg gggacaccac cagttgtcaa     1200

gctactaggc agtagggtct gagggctcag gcctccacct gagaggttat aacctgagag     1260

acagctctac ccttcctccc agtaagaagg gaaggtgggt gggcacctga gagattaaga     1320

ctattctccc agtcccacta ccagcacccc cgatccctga gactgagggg tttacgggct     1380

gtgaatggac cttcagccct gcccaccctc cctccccact gctgctgagt ctgtctgatg     1440

ttttggttgt gtgaataaat ataattcccc tctgga                               1476


<210> 3078
<211> 3583
<212> DNA
<213> Homo sapiens

<400> 3078
attcccctcc acttcttgcc tgagccgcct gctcctcttg gaaacacgtt gagcctcccc       60

gctggagagg gagccagaac agggaagaac ggattcacac aggatggctt gcagaagacg      120

ctatttcgtc gagggcgagg cccccagcag tgagactggc acatccctgg acagcccctc      180

agcctacccc cagggcccct tggtgcccgg ttccagcctg agcccggatc actacgagca      240

cacgtcagtg ggagcctatg ggctgtactc ggggccgccg gggcaacagc agcgcacgcg      300

gaggcccaag ctgcagcact cgacctccat cctgcgcaag caggctgagg aggaggccat      360

caagcgctca cgctcactct ccgagagcta tgagctctcc tcggacctgc aggacaagca      420

ggtggagatg ctagaacgaa agtatggggg gcgcctggta acccgccatg cggcccgcac      480

catccagacg gcgtttcgcc agtaccagat gaacaagaac ttcgagcgct tgcgcagctc      540

catgtcagag aaccgcatgt cacgccggat tgtgctgtcc aacatgagga tgcagttctc      600

ctttgagggg cctgagaaag tgcacagctc ctacttcgag gggaagcagg tctcagtgac      660

taacgacggc tcccagctgg gagccctggt gtcccctgag tgtggtgacc tcagcgagcc      720

caccaccctc aagtctccgg ccccctccag tgactttgcg gacgccatca ccgagctgga      780

ggacgccttc tctaggcaag tgaaatcact ggccgagtcc atcgacgatg ccctcaactg      840

ccgcagcctg cacactgagg aggcaccggc cctggatgcg gcgcgggccc gggacaccga      900

accccagaca gccctgcacg gcatggacca ccgcaaactg gacgagatga cggcctcgta      960

cagtgatgtc accctgtaca tcgatgagga ggagctgtcg ccccctctgc ccctctcgca     1020

ggcaggggac cggccgtcca gcaccgagtc ggacctgcgg ctacgggctg ggggcgcagc     1080

cccagactac tgggccctgg cccacaaaga ggacaaggct gacacggaca cgagctgccg     1140

gagcacgccg tcgctggagc ggcaggagca gcggctgcgg gtggagcatc tgccgctgct     1200

caccatcgag ccacccagcg acagctctgt ggaccttagt gaccgctcgg agcgggggtc     1260

actcaagagg cagagtgctt acgagcgcag ccttggcggg cagcagggca gtcccaagca     1320

tggtccccac agcggcgccc ccaagagcct cccccgggag gagcctgagt tgcggccccg     1380

gccccccagg cccctggaca gccacttggc catcaatggc tcagccaacc ggcagagcaa     1440

gtctgagtcg gactactcag acggtgacaa tgacagcatc aacagcacgt ccaactccaa     1500

cgataccatc aactgcagct ccgagtcatc gtcccgtgac agcctgcggg agcagacgct     1560

cagcaagcag acctaccaca aggaggcccg caacagctgg gactcgcctg cctttagcaa     1620

cgatgtcatc cgcaagaggc actaccgcat cggcctgaac ctcttcaaca agaagcctga     1680

gaagggagtc cagtacctca tcgagcgtgg ctttgtgccc gacacgcccg tcggggtggc     1740

ccacttcctg ctgcagcgca agggcctcag ccggcagatg atcggcgagt tcctgggcaa     1800

ccggcagaag cagttcaacc gtgacgtgct cgactgcgtc gtggacgaga tggacttctc     1860

taccatggag ctggatgagg ccctcaggaa attccaggcg cacatccgtg tccaagggga     1920

ggctcagaaa gtggagcggc tcatagaggc gttcagccag cgctactgca tctgcaaccc     1980

tggggtggtg cggcaattcc ggaacccaga caccattttc atcctggcct tcgccatcat     2040

cctgctgaac accgacatgt acagccccaa tgtcaagccc gagcggaaaa tgaagctaga     2100

ggacttcatc aagaacctcc gaggtgtgga cgatggtgag gacattcccc gtgagatgct     2160

gatggggatc tatgaacgga tccgtaagcg agagctaaag accaatgagg accatgtgtc     2220

ccaggtgcag aaggtggaga agctcattgt ggggaaaaag ccgatcggat ccctgcatcc     2280

cgggctcggc tgtgtgctct ctctgcccca ccgtcggttg gtctgctact gccggctctt     2340

tgaggttcca gacccaaaca agccccagaa actcggacta caccagcgag aaatcttcct     2400

gttcaacgac ctcctggtgg tcaccaagat cttccagaag aagaagaact cggtgacgta     2460

cagcttccga cagtccttct ccttgtacgg catgcaggtc ctgctcttcg agaaccagta     2520

ctaccccaat ggcatccggc tcacctcgtc tgtccccgga gcagatatca aagtgttaat     2580

aaacttcaac gcccccaacc ctcaagaccg gaagaaattc accgatgacc tgcgggagtc     2640

cattgcggaa gtccaagaga tggagaagca caggatagag tcggagctcg agaagcagaa     2700

aggcgtcgtg cggcccagca tgtcccagtg ctctagcctc aaaaaggagt cgggcaacgg     2760

aacactgagc cgggcctgcc tggacgacag ctatgccagc ggtgagggcc tcaagcgcag     2820

cgccctcagc agctccctgc gggacctctc ggaagccggg aagcgagggc gtcgcagcag     2880

tgcgggatcg ctagagagca atgtggaagg gtccatcatt agcagtcctc acatgcgccg     2940

gagagctaca tcaacacgag agtgtccatc tcgcccacac cagactatgc ccaactcatc     3000

ttccctcctg ggctccttat tcgggagcaa gagagggaag ccccctcccc aggcccacct     3060

gccctcagcc ccagccctgg ccaccccccc acccaccggt ggtcctgcct cacttgcagc     3120

actctgtggc tggccaccac ctggggcccc cagaggggct gccgcaggcc gccatgcacg     3180

ggcatcacac ccagtactgc cacatgcaga accctccccc gtaccaccat caccaccacc     3240

accacccacc ccagcacatc cagcacgcac accagtacca ccacggcccc catgggggcc     3300

acccagccta cggggcccat gcccacggcc acccgccgct gccctcggcc cacgtggggc     3360

acacagtgca ccaccatggg cagccccctg ccccgccgcc ccccaccagc agcaaggcca     3420

aacccagcgg catcagcaca attgtgtaga cagcctgggt aggggtccca ggctccctga     3480

aacacctgca caccacacag ggcacgcccg ggggtcgcca gccgcacacc aaacccgggg     3540

cacttctgtt gccatctctc ccctctgccc ctcacggccc aac                       3583


<210> 3079
<211> 550
<212> DNA
<213> Homo sapiens

<400> 3079
gtgcgtttag ggcgaagacg gagttgtaaa cttcttaaaa ttcctctctc gacacttcgg       60

gaccggaaga gtccttgaac caaaatagct cggcgggcac ttccggggcc ggcgcccaga      120

gttccgggag ggtgcaggca ggagagggaa aggcagcagc ggcggcagct ggaggatgaa      180

gaaggagcat gtgcttcact gccagttctc cgcgtggtac ccgttcttcc gaggcgttac      240

catcaagagt gtcattcttc cacttcctca gaatgtgaag gattatttac tcgatgatgg      300

aactctggtg gtttcaggaa gggatgatcc accaacacat tctcagccag acagtgatga      360

tgaagcagaa gaaatacagt ggtctgatga tgagaacaca gccacgctta cggatgcgta      420

ttggatagca atgaatagtt ctctgaaatg taaaaccctc agcgacatct ttctgctttt      480

caagagttcc gatttcatca ctcgtgactt cactcagccg tttattcatt gtactgatga      540

ttctccagat                                                             550


<210> 3080
<211> 480
<212> DNA
<213> Homo sapiens

<400> 3080
gggatgctgg ggcgcgagcg ggactgttga ctaagcttcg ttactgggcc ctggaagcga       60

ggttcaaaat gagcctgttt ggaacaacct caggttttgg aaccagtggg accagcatgt      120

ttggcagtgc aactacagac aatcacaatc ccatgaagga tattgaagta acatcatctc      180

ctgatgatag cattggttgt ctgtctttta gcccaccaac cttgccgggg aactttctta      240

ttgcaggatc atgggctaat gatgttcgct gctgggaagt tcaagacagt ggacagacca      300

ttccaaaagc ccagcagatg cacactgggc ctgtgcttga tgtctgctgg agtgacgatg      360

ggagcaaagt gtttacggca tcgtgtgata aaactgccaa aatgtgggac ctcagcagta      420

accaagcgat acagatcgca cagcatgatg ctcctgttaa aaccatccat tggatcaaag      480


<210> 3081
<211> 8073
<212> DNA
<213> Homo sapiens

<400> 3081
cagcgcgcgc tcctgcagcc ccggcggagt cccggcgggg agcgcccgcg taggcaggca       60

cccggggcag ccctccgtcc tcgccgcgcg gcctgagaac ccctgggccc tgggcgaggg      120

ggctgggctg tgcagccccc gaggctaact gggcgggatc gcagctgcag gggttgtgcg      180

agcagccacg gcggcacctg tgccctgcgg gcacccaccc tgcccctgcc gaggcaggcg      240

cccaccgccg gcggtgatgc ggctgtgaag ccctagtcga ttaacgtgac agtgtcaggt      300

ggacccacag ccatcccacc tccccctctg gggagtgctg agagtgaggc agcatggagg      360

agaggaagca tgagaccatg aacccagctc atgtcctctt tgaccggttt gtccaggcca      420

ccacctgcaa gggaaccctc aaggctttcc aggagctctg tgaccacctg gaactaaagc      480

caaaggacta ccgctccttc tatcacaagc tcaagtccaa gcttaactac tggaaagcca      540

aagccctctg ggcaaaattg gacaaacggg gcagtcacaa agactacaaa aagggaaaag      600

cgtgcactaa caccaagtgt ctcatcattg gggctggccc ctgtggtctc cgtacagcca      660

tcgacttatc cttactgggg gccaaggtgg ttgttattga gaaacgagat gccttctccc      720

gcaacaacgt cttgcatctc tggccattca ccatacatga tctacgaggt ctgggtgcca      780

agaagttcta tggcaagttc tgtgctggag ccatcgacca tatcagtatc cgtcagctcc      840

aactaatact tttgaaagta gccttgatcc taggcattga aatccacgtc aatgtggaat      900

tccaaggact tatacagcct cctgaggacc aagagaatga acggataggc tggcgggcac      960

tggtgcaccc caagactcat cctgtgtcag agtatgaatt tgaagtgatc atcggtgggg     1020

atggtcggag gaacaccttg gaagggtttc gtcggaaaga attccgtggc aaactggcca     1080

tcgccatcac ggcaaatttt atcaaccgaa atacaacagc agaagctaaa gtggaagaga     1140

tcagtggtgt ggcttttata ttcaaccaaa aatttttcca ggaactgagg gaagccacag     1200

gtattgactt ggagaacatc gtttactaca aagatgacac acactatttc gttatgacag     1260

ccaaaaagca gagtttgctg gacaaaggag tgatactaca tgactacgcc gacacagagc     1320

tcctgctttc ccgagaaaac gtggaccagg aggctctgct cagctatgcc agggaggcgg     1380

cagacttctc tacccagcag cagctgccgt ctctggattt tgccatcaat cactatgggc     1440

agcccgatgt ggccatgttt gacttcactt gtatgtatgc ctccgagaac gccgccttgg     1500

tgcgggagca gaacggacac cagttactag tggctctggt cggggacagc ctcctagagc     1560

ctttctggcc aatgggaaca ggaatagccc ggggctttct agctgctatg gactctgcct     1620

ggatggtccg aagttggtct ctaggaacga gccctttgga agtgctggca gagagggaaa     1680

gtatttacag gttgctgcct cagaccaccc ctgagaatgt gagtaagaac ttcagccagt     1740

acagtatcga ccctgtcact cggtatccca atatcaacgt caacttcctc cggccaagcc     1800

aggtgcgcca tttatatgat actggcgaaa caaaagatat tcacctggaa atggagagcc     1860

tggtgaattc ccgaaccacc cccaaattga ctcgcaatga gtctgtagct cgttcaagca     1920

aactgctggg ttggtgccag aggcagacag atggctatgc aggggtaaac gtgacagatc     1980

tcaccatgtc ctggaaaagt ggcttggccc tttgtgcaat tatccataga taccgccctg     2040

acctgataga ttttgattct ttggatgagc aaaatgtgga gaagaataac caactggcct     2100

ttgacattgc tgagaaggaa ttgggcattt ctcccatcat gacaggcaaa gaaatggcct     2160

ccgtggggga gcctgataag ctgtccatgg tgatgtacct gactcagttc tacgagatgt     2220

ttaaggactc cctcccctct agcgacacct tggacctaaa tgccgaggag aaagcagtcc     2280

tgatagccag caccagatcc cctatctcct tcctaagcaa acttggccag accatctctc     2340

ggaagcgttc tcccaaggat aaaaaggaaa aggacttgga tggtgctggg aagaggagaa     2400

agaccagtca atcagaggag gaggaagctc ctcggggcca cagaggagaa agaccgaccc     2460

tggtgagcac tctgacagac aggaggatgg acgttgccgt tgggaaccag aacaaagtga     2520

agtacatggc gacccagctg ctggccaaat ttgaagagaa tgcgcccgca cagtccatcg     2580

gcatacggag acagcaacgg gaaaaggagt gttctcggac ctgccccaaa aaagtgatca     2640

ccctgtctcc tccccctact ccacctccct gtcgggcaca tggcggccag cagacataca     2700

gggatcttga tgctgacaac cgtggcaagc agagccccca ccatgagagg ccagagcctg     2760

aacctcctcg tcgatttttt gtcgaccagt gggagctttc tcttagtctc cgctcctctg     2820

cccgccccgc ctctccctcc tccgactccc tccgacagaa gtatataaag atgtacacgg     2880

gcggagtgag ctcattggct gagcagatag ccaatcagct tcaaaggaaa gaacaaccca     2940

aagcccttct agacaagaag gaactgggct ccatgaagaa ggagttcccg cagaacctgg     3000

gaggcagcga cacatgctac ttctgccaga agcgggtcta cgtgatggag aggctgagtg     3060

ccgagggcaa gttcttccac cggagctgct tcaagtgcga gtactgcgcc accaccctgc     3120

gcctctcggc ctacgcctac gacatcgagg atggtaaatt ctactgtaag ccacactact     3180

gctatcgact ctctggctac gcacaaagga agagaccggc agtggctccc ctgtctggaa     3240

aggaggccaa aggacccctg caggatggcg ccaccacaga tgcaaacgga cgggccaacg     3300

ccgtggccag ctccactgag agaaccccag gtagcctcac ttccttgttt ggctgggtgg     3360

cgcgtcactc cctcggcctc tgtgacaagg ccaagggcat gagccagcac ctccaaagca     3420

acatttcttc attcgggcaa caagtggccc aaaaccctct ggactccttt ttcatgtgcc     3480

agctgcttgc gttcggagtc ccctttctct atggcctgtc ggaggtgctg gtgcaaatca     3540

gaggggagtt ccactggcag gctgtggccc agtgatgggg ccgtccggtg ggcggcagag     3600

ccgtgaagtg ctgtccctca gccccgtccc gcaccatcac acctgagggc ggcccaggtc     3660

ctgtgtaggt agacaggagc tcgcaggcgc tcagacactg ctcccatcac ccgccctggt     3720

gaggccaagg ccactcggcc ttcatgcagt ttgcttccaa gctcctctga cggcctggag     3780

ctgtgttgat taagccccgt ggtcttgttt tgggttcacc ttcacttaag attctgcgtc     3840

ctgttccctg tcactgtgtg tggatgagct gtggctgctc tcctgtctgc cctgcaccgt     3900

gatgggacat gccctgtcct gaccccttgg ccactgggct tgtcatgagg tccaagccct     3960

cacctgtccc actttcatga ccacttcctt gtgttgggag gtgaacagta ccatctctac     4020

ctctacaaac acatttattc ttgtcatagc atgacaggac tcgcagggtt tgtgggtacc     4080

aggcctgttg ggaagaatta tgtagatttt ccttaaaatg gcctctctca gcaacttgta     4140

aaacttgcct gtgagatgcg tccagagctc cacaaactgc tgggtgttct gaatgtccca     4200

catacagctc caggtggttc acggcccagg gtcactgtgg caagaggggg ccagcagggc     4260

tgtgtttctg tctgtcacac tttcctcttg ttcaaaacac atgtatctca agcagctata     4320

tacaaaactc ataaaaatta aagatggtca gccagtgcca ggaaatgtgg aggaggagtt     4380

ggtcatagaa tttccatggt gggacaagag aattacccat ttggccttca acgagaggtt     4440

cccagagttg catcctttcc cttccctaac agctggttca tgtaggcctt gtggtgctca     4500

ttctgggaga gggaagatgc gcccagaggc taggcggtgt gccctgggag ccatgagaac     4560

ccagccaagc caggtgaacg cagcttctgc tactgcacgt gcccttatta tcatctgagc     4620

aagtttttta agtaccctgc aggtgggacc aacattttat agccatgttt caaccattaa     4680

tgacttttaa accttctaca atcttgaaga tctttataat ccatctttct cgtgaagtac     4740

ccacaggcct ttgcagctga cactctcaga gcatgggcag aatcactggt agagaaaaat     4800

aaccaaaggg gtctagacag agactttggc tttatgctat agaatgtaca ttcagttgga     4860

gagagcacca ccttattagt ctgggcccta tttcatcaga gatggatttt gtgaggaacc     4920

tgactactca gtagaacaac tcaaaagaaa ctaaactttc catttcggtt tggagtacag     4980

aacatttttt aaaaagaatt aaacacagtg aagtttaggt tattcctgaa tgacgccagg     5040

tttgctgact ttcccatctg gtcgaggttg ccattcttgc catctaattg aaagtataat     5100

gggtttcagg tttttaggag ttctaaagaa ttacgctttc catagagaat aagaggaaga     5160

atgttctaca tagtggggag agaggatgag ggttggcagt gtggttaaag agcaaaacca     5220

ccaagaaaga gtcagagccc tgaggacgtc tctgtccgcg tggttcttga ttctgagcca     5280

gaaggtgact tggtatagca cgggagttca aaatgtggtg tcccaaagga atcacagtgt     5340

ggacctttac agttaatgac aggcactgtc ccccagcttg ggtggcaaag gccagtgagc     5400

tcagggctga ggggcttacc ctccggcagc tcagagtcca gaacatctta gtccggcagc     5460

tcagaatcag ggcaccttgc ctcccggtga gctcactctg ctgctagcct tggtagaaaa     5520

ggaacaggat tatgggcagt attttatggc tggcatgaaa tagataccct tttctccttt     5580

gatagagatt tccttcttta aatatgaaac tgaagctttg aggacttaac tagacttcct     5640

tttgaaaagt ttcagaaaag ctcaggtgtg gccaggcacg atggctcatg cctgtaatcc     5700

cagcactttg ggaggccgag gcgggcagat cacgaggtca ggagatcgag accatcctgg     5760

ctaacacagt gaaaccccgt ctctactaaa aatacaaaaa aattagccgg gtgtggtgtg     5820

gtggcggatg cctgtagtcc cagctactcg ggaggctgag gcaggagaat ggcgtgaacc     5880

caggaggcag aggttgcagt aagtcgagat cacaccactg cactccagcc tgatgacaga     5940

gcaagactcc atctaaaaaa aaaaaagaag aaaagggaaa gctcaggtgt ttcagggtcc     6000

cagaatgtat gttgtagaga acagtcatta gctcaggccc atggtaaccg cctctactgt     6060

gcactcgacc agtagaggcg atgatgacgg cacttgattc tcttgtgtgt aactcagcca     6120

tcctccctag acccacgtcc caggaggcag ggctggtaaa gctatgactg ggcagtgttt     6180

gacccagctg tgcttttact ctgtgcctcc tctttatatt gtggcatttc tctcttctcc     6240

tttatgttct ttttcttttt atgccaaaat tcttgctgtt gccaaaacaa aaacaaaaaa     6300

acacacccac acccaattac aacctgcagt tcaaagaacc actctaggtc ggctttaaag     6360

tattgtcttt ctctggtaac caaatctgta cctgctgcct aatttagtgt ttgggggcat     6420

tgtttacagt atttctgttt gtaatgtgct tttaatatag aaatcctctt ttttgttctt     6480

aaatctatga atgctgtgtt tccaagctta tacttactac tgcgtgttag tggtcctggc     6540

acagattttc ttaccctggc cttgtactgt ccaccatgac tttagaaaaa gcttgaacaa     6600

taggcagaga aaggaaatcc ccaaaaggga ttattttccc cttggacatg agaagtttag     6660

ttacaggttt cttgaattcg tttttgtcca gaggaatcct ctttttatct gatacggttg     6720

atgaccaaaa atgaagtagg gaagccgaag gcatagccgg aaaggaacag aagagctttt     6780

tccccgagtg ctcatcaccg ggttcattac cggccagaga tggacgggga gaagcacgtt     6840

agtttcctgt catcttatgg aaaagatgat ctgaagttaa aaaatgaagg tcacaagtgg     6900

cagttgcctg acccctgtcc ccagacattc cttgcccgat aaccatgagg ttccatagtt     6960

cggatcctga atgggccttt aggaaatgca ggcctttccc acaccagcta gaagggtagc     7020

caggcagtag aatttcattc aaccctaggg ttcccacctg acagagggaa gttcggaagt     7080

cttactgctt cccacgtccc cttcccttct aggcatttat ggaaagcttt ttagtggagc     7140

aagagaattc tacaatccag cttacctccc accttacccc aagagccata gctgacggtg     7200

atgtgtgaat gtttatatat aggtacacgt ttgtatgtat atagatctaa ttgcacatat     7260

atgggtagat atttatttat atgttgcacc ctaaattata gtaattataa taattgtgaa     7320

gctgtttcta aagctgcttg ttcctggttc tgagaaccac gggagcctca cactggggag     7380

ccgtactcca ggtcagggct ttggggatgc acagcagcgt acgggcagca cgcctgtaag     7440

gaggtgagtg ggtgggtgtc tcagaaaatg ggcagcacac ccccaagaaa gggccccaag     7500

agcagactag gaacgcaggg ggctgctgct gccaggacac cacggagagc cgggcacccg     7560

cctcacatgt ctcctgtctg gctccactga gttagccgtt tgagcccact cctatctttt     7620

ggtggttagt gcatcttcag ctcttttctg caagacactg gaacattcct aggctgtccc     7680

aaaaggagtt ccaccatagc ctttaaggtc cgagcagggc accaaggggt tcacttttct     7740

cccgagccat tcagcttggg gtgcctgcgg gaggggcgga cagccagccg gcttcccggc     7800

ggcggtacga gagcccaaca ggagaggatt agctgtgcca aggaacacgc cactgctgcc     7860

tgtctactgc ccgccttctc tccacttcca tttttgcctt tgtttttaac ttgtgctctt     7920

gtgagttctt ggtgtgtttc tttgtgagtt tttatttaat tgtgtaactt tgtttttgcc     7980

gttgactgtg aaaccaagtt gtcgtgcttt taattttttt tttaacaaat gttacattct     8040

tatttaagag aataaattcc aaacaatctt cgg                                  8073


<210> 3082
<211> 1538
<212> DNA
<213> Homo sapiens

<400> 3082
aagcgctgag gcggtggggc ccacagccat ggcggagcct gtgcaggagg agctctcggt       60

cctggccgcg attttctgca ggccccacga gtgggaggtg ctgagccgct caggaccaga      120

aaataacaca gagaaaaatg aaaattggta aggactgaca tggctggctc agtagctttt      180

caagactttc cccctggact accaacatgt ttctttcctg tggttccctg caccagagag      240

gacccgagac agatgggacc gtgttcagaa ttcacacaaa agctgaagga tttatggatg      300

tggatatacc tctggaattg gtgttccatt tgccagtcaa ttatccttca tgtctacctg      360

gtatctcgat taactctgaa cagttgacca gggcccagtg tgtgactgtg aaagagaatt      420

tacttgagca agcagagagc cttttgtcgg agcctatggt tcatgagctg gttctctgga      480

ttcagcagaa tctcaggcat atcctcagcc aaccagaaac tggcagtggc agtgaaaagt      540

gtactttttc aacaagcacg accatggatg atggattgtg gataactctt ttgcatttag      600

atcacatgag agcaaagact aaatatgtca aaattgtgga gaagtgggct tcagatttaa      660

ggctgacagg aagactgatg ttcatgggta aaataatact gattttacta cagggagaca      720

gaaacaacct caaggtgcca aaaagttaaa tgttgagtat gaatctggct attttctgct      780

ttaaatggtg tgtctttaag tgtgttttat aacaatggga tagattaatt attaagatgt      840

ttctgctttc attattacaa tcttaatgga tcttcctttt ctttttaaag aatgtctgac      900

tgctaattac aagtacaaac ttgcaaagct tgaagaataa gattgcattt taaaaatcat      960

gtcacttaat aaagtgacag gttatttaaa agctctgtgg cacatgagtg tttgtttctg     1020

taattagcta tgagcttgaa ttttataaat gtgcactaaa agtttgtgca tattaatatt     1080

tcttcccata gttaggcaca gcaaggtgtg tatttgtgga tagtctgcaa gatttgtaac     1140

tttctggctg ttaaaaatac attctgacac tttaatttgg tatctataat acctggaaag     1200

aggagcttgt ctgttataac cgagatttca tgttagtaga agtagaatca ttagggctgt     1260

caacttgtca cctcctacct aacttttgct ttccacctga cttgtctcag cagttgcttt     1320

caaaatcatc atcttcttca gatttttcaa gttcttattc taaactcatc tgacctgttt     1380

taggtgggac aagatgagga aaactgtttt ttatatttta aatattagaa gagctacaaa     1440

tcaataggtt ttatactttc agataggtta ggtcatgaat aattacattt gaatttattt     1500

aagacaaatt tagtgtgaac agtgaattta tttaagac                             1538


<210> 3083
<211> 2794
<212> DNA
<213> Homo sapiens

<400> 3083
agatatccaa ggggaggcgt ccaggaggta gttgggtttc caagtctggg gttggagggg       60

caggtccagg ctgcctgagg gtaggggtag catttaaggc catgcggtgg ggggagtggt      120

tcacggtggc cctcaggagg aaggaaggaa aaacagccgt ctctggcctc tggcctctcc      180

aggctctcca ccctgggggc agaatcaatt ctgtagccct ctagcaccgg cagtggctcc      240

gcagtcagct gggcagtggc cgtgactggg tcactctacc ctaggaagtg agtgcagggg      300

ctgctggaga gccagaggct ggcagcgact atgtgaagtt ctccaaggag aagtacatcc      360

tggactcatc gccagagaaa ctccacaagg aattggagga ggagctcaaa ctcagcagca      420

cggatctccg cagccatgcc tggtaccatg gccgcatccc ccgagaggtc tcggagacct      480

tggtacaacg caacggcgac ttcctcatcc gggactcact caccagcctg ggcgactatg      540

tgctcacgtg ccgctggcgc aaccaggcct tgcacttcaa gatcaacaag gtggtggtga      600

aggcaggcga gagctacaca cacatccagt acctgtttga gcaggagagc tttgaccacg      660

tgcccgccct cgtgcgctat catgtgggca gccgcaaggc tgtgtcagag cagagtggtg      720

ccatcatcta ctgcccggtg aaccgcacct tcccactgcg ctacctcgag gccagctatg      780

gcctgggaca ggggagtagc aagcctgcta gccccgtcag cccctcaggc cccaagggca      840

gccacatgaa gcggcgcagc gtcaccatga ccgatgggct cactgctgac aaggtcaccc      900

gcagcgatgg ctgccccacc agtacgtcgc tgccccgccc tcgggactcc atccgcagct      960

gtgccctcag catggaccag atcccagacc tgcactcacc catgtcgccc atctccgaga     1020

gccctagctc ccctgcctac agcactgtaa cccgtgtcca tgccgcccct gcagcccctt     1080

ctgccacagc attgcctgcc tcccctgtcg cccgccgttc cagtgagccc cagctgtgtc     1140

ccggaagtgc cccaaagacc catggggagt cagacaaggg cccccacacc agcccctccc     1200

acacccttgg caaggcctcc ccgtcaccat cactcagcag ctacagtgac ccggactctg     1260

gccactactg ccagctccag cctcccgtgc gtggcagccg agagtgggca gcgactgaga     1320

cctccagcca gcaggccagg agctatgggg agaggctaaa ggaactgtca gaaaatgggg     1380

cccctgaagg ggactggggc aagaccttca cagtccccat cgtggaagtc acttcttcct     1440

tcaacccggc caccttccag tcactactga tccccaggga taaccggcca ctggaggtgg     1500

gccttctgcg caaggtcaag gagctgctgg cagaagtgga tgcccggacg ctggcccggc     1560

atgtcaccaa ggtggactgc ctggttgcta ggatactggg cgttaccaag gagatgcaga     1620

ccctaatggg agtccgctgg ggcatggaac tgctcaccct cccccatggc cggcagctac     1680

gcctagacct gctggaaagg ttccacacca tgtccatcat gctggccgtg gacatcctgg     1740

gctgcaccgg ctctgcggag gagcgggcag cgctgctgca caagaccatt cagctggcgg     1800

ccgagctgcg ggggactatg ggcaacatgt tcagcttcgc ggcggtcatg ggtgccctgg     1860

acatggccca gatttctcgg ctggagcaga catgggtgac cctgcggcag cgacacacag     1920

agggtgccat cctgtacgag aagaagctca agccttttct caagagcctc aacgagggca     1980

aagaaggccc gccgctgagc aacaccacgt ttcctcatgt gctgcccctc atcaccctgc     2040

tggagtgtga ctcggcccca ccagagggcc ctgagccctg gggcagcacg gagcacggcg     2100

tggaggtggt gctggctcac ctggaggccg cccgcacagt ggcacaccac ggaggcctgt     2160

accacaccaa tgctgaagtc aagctgcagg ggttccaggc ccggccggag ctcctggagg     2220

tgttcagcac ggagttccag atgcgccttc tctggggcag tcagggtgcc agcagcagcc     2280

aggcccggcg ctatgagaag ttcgacaagg tcctcactgc cctgtcccac aagctggaac     2340

ctgctgtccg ctccagcgag ctgtgacccc agggacattt cccctctgca gctgcggaca     2400

gcgtcagggg cagaggggca cacaactttc cccagagcac cccaaggaca ctgtgatcaa     2460

cccgagaatg ttctgggttc aactcaagca tctcccttgc acctccaggg tcctgcgtgg     2520

actctgggtt ccatcccacc tgctacatgc tcaccaggtc tccattgagg aagaacagga     2580

acgccggttc ccccaccagc ttttgctgct ccccttcctg ctggggttcc ctgttttcga     2640

gccatgggag gcaggctgct cacgcctcct cactctctgt ctgtccctca ccaacaccaa     2700

ggcctccatc tcactgtaaa taagtctctg ttctgtaaat agatgtacag aagccatgtt     2760

atttctttca tataataaac ttttatgact cttt                                 2794


<210> 3084
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3084
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cgaagtcctc      180

accagtgaac ggagacctct ctgaactaag gataccatgg ccacgtcagc cccactacgg      240

agcctggaag aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc      300

attgactgtg gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg      360

agccgccccg tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg      420

tggcaactgg ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag      480

ccgggagagg tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag      540

ctgcactact actgtgagga cgacgggaag ctgctgtgcg tg                         582


<210> 3085
<211> 1017
<212> DNA
<213> Homo sapiens

<400> 3085
tgtggccgga ggctgatcag gtactgtgga cgggcggcgg agttcgggag acaggggcag       60

ggcggcatcg gggagctgcg ggacggggcg gggaggaggc ccgaggtctg agccacccgt      120

gaggtctcgg cgcggaggcc tggacagctg ggggtggcgg cgttggtctc ccgaactgga      180

gggaggccgg gccttcccgg gctgtggtgg gcgcccgcgc cccgtggaag gcggaggcgt      240

gagtcggggc gtcagagacg ttgccattct ttgtcagcgg aaaagatcgt cgtctgcgca      300

cagtcacctg aggtttagga actcgtggaa ctggaaaccg agtcgcagga gactaagagt      360

tgcgagtctc cccttagaga attcagaaac aagcgtagac agcatcgtca gaaacacgag      420

cgtgacgaca ccggcctccc cgtgccgagt ccacgcgtgt gacgcgggtg catacacctg      480

cgtccgtgca agagggtgac agcaacacac tcaaggcgct tctcctggga atggagcagg      540

agaagagatg gggagcatcg catagatgga actagacctt tttcttgggt tggatgatgt      600

gttcccgcgt ctactacatg tgttctagaa cagatcagac attttgtaat gatgcctgaa      660

ataaacacta accacctcga caagcaacag gttcaactcc tggcagagat gtgtatcctt      720

attgatgaaa atgacaataa aattggagct gagaccaaga agaattgtca cctgaacgag      780

aacattgaga aaggattatt gcatcgagct tttagtgtct tcttattcaa caccgaaaat      840

aagcttctgc tacagcaaag atcagatgct aagattacct ttccaggttg ttttacgaat      900

acgtgttgta gtcatccatt aagcaatcca gccgagcttg aggaaagtga cgcccttgga      960

gtgaggcgag cagcacagag acggctgaaa gctgagctag gaattccctt ggaagag        1017


<210> 3086
<211> 2117
<212> DNA
<213> Homo sapiens

<400> 3086
ggacccaggg gttacgaccc atcagccctt gcgcgccacc gtcccttctc tcttcctcgg       60

cgctgcctac ggaggtggca gccatctcct tctcggcatc atggccgccc tcagacccct      120

tgtgaagccc aagatcgtca aaaagagaac caagaagttc atccggcacc agtcagaccg      180

atatgtcaaa attaagcgta actggcggaa acccagaggc attgacaaca gggttcgtag      240

aagattcaag ggccagatct tgatgcccaa cattggttat ggaagcaaca aaaaaacaaa      300

gcacatgctg cccagtggct tccggaagtt cctggtccac aacgtcaagg agctggaagt      360

gctgctgatg tgcaacaaat cttactgtgc cgagatcgct cacaatgttt cctccaagaa      420

ccgcaaagcc atcgtggaaa gagctgccca actggccatc agagtcacca accccaatgc      480

caggctgcgc agtgaagaaa atgagtaggc agctcatgtg cacgttttct gtttaaataa      540

atgtaaaaac tgccatctgg catcttcctt ccttgatttt aagtcttcag cttcttggcc      600

aacttagttt gccacagaga ttgttctttt gcttaagccc ctttggaatc tcccatttgg      660

aggggatttg taaaggacac tcagtccttg aacaggggaa tgtggcctca agtgcacaga      720

ctagccttag tcatctccag ttgaggctgg gtatgagggg tacagacttg gccctcacac      780

caggtaggtt ctgagacact tgaagaagct tgtggctccc aagccacaag tagtcattct      840

tagccttgct tttgtaaagt taggtgacaa gttattccat gtgatgcttg tgagaattga      900

gaaaatatgc atggaaatat ccagatgaat ttcttacaca gattcttacg ggatgcctaa      960

attgcatcct gtaacttctg tccaaaaaga acaggatgat gtacaaattg ctcttccagg     1020

taatccacca cggttaactg gaaaagcact ttcagtctcc tataaccctc ccaccagctg     1080

ctgcttcagg tataatgtta cagcagtttg ccaaggcggg gacctaactg gtgacaattg     1140

agcctcttga ctggtactca gaatttagtg acacgtggtc ctgatttttt ttggagacgg     1200

ggtcttgctc tcacccaggc tgggagtgca gtggcacact gactacagcc ttgacctccc     1260

caggctcagg tgatcttccc acctcagcct tccaagtagc tgggactaca gatgcacacc     1320

tccaaacctg ggtagttttt gaagtttttt tgtagaggtg gtctagccat gttgcctagg     1380

ctcccgaact cctgagctca agcaatcctg cttcagcctc ccaaagtact gggattacag     1440

gcatcttctg tagtatatag gtcatgaggg atatgggatg tggtacttat gagacagaaa     1500

tgcttacagg atgtttttct gtaaccatcc tggtcaactt agcagaaatg ctgcgctggg     1560

tataataaag cttttctact tctagtctag acaggaatct tacagattgt ctcctgttca     1620

aaacctagtc ataaatattt ataatgcaaa ctggtcattt ttgggatttt gtttttgaga     1680

ctcattctgt caccccggct ggagtgcagt ggcttgatct tggctccctg caacttctgc     1740

ctcctgggtt caggcgattc gattaacaat tggagacgag tcgtgcagag gaaagaagta     1800

acttagaatc taatctttat taacctggga tatcacagaa aatacttggg cctgccactt     1860

gtatttcttt gtcctcaata ctgaacacta gacacatttg aaaccttcct cagaaggaaa     1920

caaaccaact ggttatgcct gggtggtggc atggaagatg cccattgttg cccaatttgc     1980

taataagtat tttgaaatta gaaatgaaac atgaggtcca agcctgtcca gttccctacc     2040

caacccattc ctcctccctg gaaaaaagaa acccgtatca tcttccaaat ttctgattca     2100

tcactgccac ttaaaaa                                                    2117


<210> 3087
<211> 7242
<212> DNA
<213> Homo sapiens

<400> 3087
cacaaattcg cagcaggcgg ctggggcggc ggctggggca gcggctgcag cagcggcgga       60

cgctctgcat tacccagtct tgcgtcctcg gcaggcgccc gaagctgagt gcgcatcctc      120

taccgcaccc aagcttcgtc tgtctcgtca agctcttcat gctgcccaac taaaaggaaa      180

acatgggcac aggggatttt atctgcattt ccatgactgg aggggcgccc tgggggttca      240

gattgcaagg tggcaaggag cagaagcagc ccttacaagt tgcaaagatt cgaaatcaga      300

gcaaagcctc tgggtctggg ctctgtgagg gagatgaagt ggtttccatc aatggcaacc      360

cttgtgcaga tctcacctac cctgaagtca tcaagctcat ggaaagcata acagactctc      420

tccaaatgct catcaaaaga ccatccagtg gaataagtga ggctttgata tctgaaaatg      480

aaaacaaaaa cctcgagcat ctcacacatg ggggttatgt ggaaagtacc accctgcaga      540

ttcgaccggc cacaaagacc cagtgcacag aattcttcct cgcccctgtc aagactgaag      600

ttcccctagc tgagaaccaa agaagtggtc ccgactgtgc aggcagcttg aaagaagaaa      660

caggcccgag ctaccaaagg gctccccaaa tgcctgactc ccaaagagga cgcgtggcag      720

aagagctgat cttaagggag aaggtagaag cggtacagcc tgggcctgtg gttgagctgc      780

aactgtccct ttcacaggag agacataagg gcgctagtgg ccctttagtg gctctcccgg      840

gagctgaaaa atctaagtct cctgacccag accctaactt gtcacatgac aggattgtcc      900

acataaattc gatccctact aatgagaaag cagacccttt cctgaggtcc agcaagataa      960

tccagatctc cagtggcaga gagttgagag tgatccagga aagtgaagca ggagatgcgg     1020

gactgccccg ggtggaagtg atcctcgact gctctgacag gcagaagaca gaagggtgca     1080

ggcttcaggc aggaaaggag tgtgtggatt ctccagtgga aggagggcag tcagaagcac     1140

ctccttctct ggtatccttt gccgtctcat cagaaggcac agagcaggga gaagatccac     1200

gctcggaaaa agatcacagc agacctcaca agcaccgagc gcggcatgca cggctcagga     1260

ggagtgaaag cctgtcagaa aaacaagtga aggaagcaaa atctaaatgc aaaagcattg     1320

cccttcttct aacggatgct cccaacccca actccaaggg ggtgttgatg tttaagaagc     1380

gacgtcggag ggccaggaaa tacaccctag ttagctacgg tactggcgag cttgagcgag     1440

aggcggacga ggaggaagaa ggtgacaagg aggatacatg tgaagtagca tttcttggtg     1500

caagcgaatc agaggtggat gaagagttat tgtctgacgt tgacgacaac acacaagttg     1560

tgaactttga ctgggattct ggactggtgg acattgaaaa gaaactgaac agaggggaca     1620

agatggagat gttaccagac accacaggca agggagccct catgtttgcc aagaggaggg     1680

agagaatgga tcagatcaca gcccaaaaag aagaggacaa ggtaggtgga acgccaagca     1740

gagaacaaga tgctgcccag accgatggcc tgagaaccac gacttcttac caaagaaagg     1800

aggaagagtc ggtaagaacg cagagctctg tgagcaaaag ctacatcgag gtgagtcatg     1860

gtcttggcca tgttccccaa cagaatggct tcagtgggac atctgagaca gcaaacatcc     1920

agaggatggt ccccatgaat agaacggcca aacccttccc agggtctgtg aatcagccag     1980

ctaccccctt ctcgccaacc cgaaacatga cgagtcccat tgctgacttt cctgcacctc     2040

caccttactc tgcagtcact cctccccctg acgccttctc cagaggggtt tcaagtccga     2100

ttgctggccc agcacagccc cctccatggc cccagcctgc cccgtggtcc cagccagcct     2160

tttacgattc gtctgagcga atagcttccc gagatgagag gatctcagtg ccagcaaaaa     2220

gaacaggaat attgcaggag gccaaaagga gaagcacgac aaaacccatg tttactttta     2280

aagagcccaa agtaagccca aatcctgaac tcttgtcact ccttcaaaat tcagaaggca     2340

aacggggcac tggagctgga ggtgattccg gaccggaaga agactacctc agcttggggg     2400

cagaggcttg taatttcatg caaagctcct ctgccaaaca aaagacccct cctcctgttg     2460

ctccaaaacc tgcagtcaag tcctcatcct cccaaccagt aactccagtt tccccagtct     2520

ggtctccagg agtggctccc acccaacctc ctgccttccc cacatccaac ccatcaaagg     2580

gcaccgttgt ctcctccatc aaaatagccc agccttctta ccctcctgcc cggcctgcaa     2640

gtactttgaa cgtggctggt cccttcaaag gaccacaagc agcagtagcc agtcagaatt     2700

acacacccaa accaacagtt tccacaccaa cagtcaatgc tgttcagcct ggtgcagtgg     2760

gaccatccaa tgagcttcca ggaatgagtg ggagaggagc tcagctcttt gctaaaaggc     2820

agtcgagaat ggagaagtat gtggtcgatt cagacacggt gcaggcccac gctgctcgag     2880

ctcagtctcc cactccatct ctcccggcca gttggaagta ctcctccaat gtccgagcac     2940

ctcctcctgt ggcctataat cctatccact cgccgtctta cccactggct gctctcaagt     3000

ctcagccatc agctgcacag ccctccaaaa tgggcaagaa aaagggaaag aaacccctca     3060

atgcattaga tgtcatgaag caccaaccgt atcagctcaa tgcatccttg tttactttcc     3120

aacctccaga tgcaaaggat ggcctccccc agaagtcatc agtcaaggtc aattcagccc     3180

tggccatgaa gcaagctctt cctccccggc cagtgaatgc tgcctcacct acgaatgtgc     3240

aggcttcgtc agtgtactcg gtaccagcct atacctctcc tccttccttc tttgcagagg     3300

cctcctcacc agtcagtgca tccccagtgc ctgtgggcat tcccacctcg ccaaagcaag     3360

aatcagcctc atcatcttat tttgtggcac caaggccaaa gttctcagcc aagaaaagtg     3420

gtgtcacaat tcaggtgtgg aaaccatctg ttgtggaaga gtaatcttgt agctgaagct     3480

gagtgtccac tttgcttgaa atgaattgtt tgcagtgttt cttgagtccc tgagaatgcc     3540

tagcaaagtc ctcaacttac ttaatttcag atatgtcacc tcctaatctg ggtccaagga     3600

gtataatatt tttaatgagt caaaaatcca actcagattg acctaaaata tatttatctt     3660

ctttgcacac ttaaaaaatc caggagcacc ccaaaataga catgtaccgt tatattaagt     3720

aagcaggaga cttaggattt gtgctgtagc cacaagaaag acagtgatca gtgatatcaa     3780

acatcaggaa tcagccttta tgtaacataa cagctgtcct cctatggtga aaggttcaaa     3840

tgtagtgaag gtataaccta tattgactga gatttccctt ttaggtagtg ccttatctct     3900

attactagtg ttaaaggaat aaggaatcta tgaaggacag ggagcagctc tggtctgtca     3960

atctcagcca cctgtttgat atcacagaga agatactcgg aggattgttg gaatgtatat     4020

agtttagtaa gaagtgggta agaaagaggg tcttaattac tgagcactta ttatgtatta     4080

ggttctttgc cagatgtttt tacatatata aactcatttc agaaaactta tttaaagtaa     4140

atggggccgg gtatggtggt tcatgcctgg aatcctagca ctttgggagg ctgaggtagg     4200

aggactgctt gaggccggga gttggagacc agcctgagca acatagtgag accctgtctc     4260

aataataata ataataatag taataatgaa gtaaatggga taaggaaaga aggataatta     4320

tctttaaagg ttgattccca ccctccctcc ccagttactt aaggaactaa gtgagtacat     4380

ctccagttgc ccatgaaagc ataagtttgt tttcctcagc tgaggcaagt ggtagagtat     4440

acaggataac gaagtaacat gtaaaaggca ggacgcacat aaaggtgtac atggctattg     4500

tttcacctgg agaaaccaca tgattgggac ctgaaggttt actgactgac tacaggggct     4560

gattgtgaag cacgaggaac cccatgtgtg tggagactgt agggtgagag cacacaatta     4620

ttagcatcat ttctgagtga tctcacagat tttttttctt gtgtttgctt tgctttttga     4680

caactgcttc tcccacgttc cttgcaattc tattctctca ccttcacttt actatttgta     4740

ttcgatggac caggataatt caggcaaggt taccttgtaa actttaattg gccacacacc     4800

atgttgtcac ccagctggct atgaagtgaa taatggtact gaaagtaaac ctgaagacct     4860

ttctcagatc tattttaagt ctgagtctga ccaaccatgg aaaatattcg acatgaatta     4920

atgtagagaa ctataaagca tttatgacag ctccaagaaa aatcatctac tctatgcagg     4980

agatatgttt agagacctct cagaaaaact tgcctggttt gagggtacac agtaccattt     5040

taatcttctg aaaatatctg tattcctgct ctttttctgc tgtcactgtc aatctgctat     5100

atttttcact atcctattaa aatattactg tctcctttat ctgttcaatg tccatatttt     5160

aaaaaaatct tccttgtatg agctattctg atctaaataa tttctctgat atttctctat     5220

atggctccca caacaatttc attgttgtta gcatatctat ttctccatac attgtaaaac     5280

tgtaatcctt aggtatttct aaaacataaa gaggagaatt aagtcagctg cagaacaatg     5340

gggctgattc ttctgctttt tctctggaaa atctttcatt gcttttggtg gaaatttacc     5400

tagaggttac aaccacagga tgtagcttgg tctcttattt gcctttttgg gaaaccaatt     5460

aagattaata caggataaag gaaaaaagca atctattcat tatataacac agttgtttgt     5520

attacttgtt ccctgcaaag gaaatctgtt gaatgcttgc attttgaatt cttttctaat     5580

agaacaacca aaaaaggctt cttatggtgc agcaggaaaa aagatcattt ttatagcttt     5640

gcattcttaa catagcattt aaagagcggc atgaattaga ggaaagacat ggaacacaca     5700

ggtagtcggt ttgagatcat cggcttaaaa gtatcctagg atggtaatga cccagaagta     5760

tttccagttg tctagtggtg tggtatgcag gaatgagaag tgttttcttt ccatttcctg     5820

ttggacaggt ggcaatctta gcagagccac tatttggagt tgataactaa agatgcaaat     5880

aacatgacta tgccttctgg tcatcctagg actatttgga gttctccaaa accttgtaag     5940

aggcatgtca ggcatgcagt aaaagcatct acaacttcag ctgggcactg gcagcatagg     6000

tctcatcttg gaccatacag tcccacttta tagaagaggg tggaagttct ccaaaacaat     6060

atccacaaca aagtctgacc tcactctgag ggagatggga agtgggagga agaaggacta     6120

accagctccc tggagtaaga ggaatttgct ttccctgtct gcccaccagg ggctatatgt     6180

gccacctttc aggttggggc caaggaagtg atgtcagtgt gacagaaggg agagttagac     6240

ctccagacgt cagcctccct cccatggggt acattttcaa tctgagtgtt gttgccttag     6300

ctgtgttggt attagcttga ttggttggtc cgctggttat gaggtgtagg gaggcagttt     6360

ttgtttagtt tttaggactt tgcctcttcc tttgtcctta gcataatttc taggcagagc     6420

atccacgaag tcggttttca ttgccagctc aagagcgaca atcatttacg agttcctatg     6480

ttatgttagg tgccttatgt atattatccc aaatccactg catggtttaa atacaggcac     6540

tggaatataa atgaaaaagg tcattacagt cactgacttt ctgcaggacc ttaaacattt     6600

ctctttccac aagtttcccc ttaatcatgt gtcaaacctc tcttcctgac gggaatgttg     6660

tgctataatg aatctgcata acgcttggga ttctaggagg aaggaaggtt ccatggacat     6720

gtaagtacag catattcccc tcagtcttct aggagggcag agtgaatccc agaactggta     6780

agattgggaa tctgagcatt gccactttaa tcttagaata tttatcattt tgacacatcc     6840

tgttttttag agaggaaaac aaacacagtt tctgcattgg tagtgtaaag cataccttgt     6900

taggaacgtg ttttgtaaga cacatttggg ttgtcactct agagcatgtc aaactttgta     6960

cttcaaaata tatttagtat gattgttagt ggtaacatat atcaaggctt tgaattaact     7020

gttttattta attttcacaa gaagcactta ttttagccat aggaaaacca atctgagcta     7080

caaatagttc tttaaaataa gcccaggtta tttagctatt ctagaaagtg ccgacttctt     7140

tcaagaagca ggcattgtag gacagctgag aattatcaca tagcctaaat tctagcctgg     7200

cagcaagagt cacatctgag atgtccaaaa aaaaaaaaaa aa                        7242


<210> 3088
<211> 701
<212> DNA
<213> Homo sapiens

<400> 3088
cagaggaggg ggctctgctg gggagagggg ctcagtctgt tcttgtgagg ctgagggtct       60

ggggtcgcct gcgaggccgc tggccaggcc tgagcctctg ccaccatggc cattgtgcag      120

actctgccag tgccactgga gcctgctcct gaagctgcca ctgccccaca agctccagtc      180

atgggtagtg tgagcagcct tatctcaggc cggccctgtc ccggggggcc agctcctccc      240

cgccaccacg gccctcctgg gcccaccttc ttccgccagc aggatggcct gctacggggt      300

ggctatgagg cacaggagcc gctgtgccca gctgtgcccc ctaggaaggc tgtccctgtc      360

accagcttca cctacatcaa tgaggacttc cggacagagt caccccccag cccaagcagt      420

gatgttgagg atgcccgaga gcagcgggca cacaatgccc acctccgcgg cccaccacca      480

aagctcatcc ctgtctctgg aaagctggag aagaacatgg agaagatcct gatccgccca      540

acagccttca agccagtgct gcccaaacct cgaggggctc cgtccctgcc tagcttcatg      600

ggtcctcggg ccaccgggct gtctgggagc cagggcagcc tgacgcagct gtttgggggc      660

cctgcctcct cctcctcctc ttcctcctcc tcttcagctg c                          701


<210> 3089
<211> 2484
<212> DNA
<213> Homo sapiens

<400> 3089
ggatgccagc tgagtgctgg ccgtgggccc ctggtcctgg cacgagagga gcctctgttc       60

ccaaagctgg ggtagatgtg ttgctggact cacgtgcaca cacacacgtg catgggccga      120

gggcagggcc cgcagtcccc tggtgtgggt agaacaccct gaccatctct ggcgtggaga      180

gggccttcca tcccccaggg tgtgcctcag ggccccgaag cccaggctgg ccctccccac      240

tcttcctgta ctcctggctc aggcccctgg tgcctttggg tccccacgcc atctgcccat      300

gggcctgagg ccctaggcct ggggagggct gtcccatgga tctctgccgc agtactgtgg      360

ctcagtgaag ggtgccaagt acacctgtgc cctccgctgg tagctgctct aacacccttc      420

tgagcccgca ggccccatga ccagggaggg agggagggct gtgagcagag tcctgccctg      480

ccccccagat gtccatgggc acagcaagcg gggatggtcc tctgtggcca ccagagctgg      540

cctcctacct ggggtggccg gacatccgcg tctgcagagc ggggcccacc ccgcccgccg      600

aggcagctga gctgtcctgc gagtggattg gtttgaggtc aaggtgctgc tgctactgcc      660

ttctgccctg tgcacccacc tacccaccca cgatcccagt ggagcctctt tcctgactcc      720

cagcatcctc ccacagcccc accccaactg ctggctgcac tgggcaggcc ttgcgtatgg      780

ctggaggctg aggcagggtt cgctggagga aggggtgggg cggggccgag ggtcacccct      840

gcttggtgga gcctgctgtc cctacccgac gtggtgcact ggtggtgttt gacccaagca      900

tgcggctcgc catcatgccc cgctacagtg caggagcgca gctgctgcca ggcttagagc      960

aggggctggt gaggaggcca ggactctgcc caggagggcg gaacctgaag ctttgggtct     1020

gacaaactca agcaggcagc agggagggac tgcagtggcc ttgcttgcgc tctgactggt     1080

ccttgcctgt ctgtgtggtc cagcctgggc cgcagcaggt cctggtgggg aggtttactc     1140

tgttttgggg tctgtcaggc actgctttcc caccacctgt aagggggttt cccacctaat     1200

cagctgcaga ctgctcccgg gttgcagcca ctggcctggg agcaccaggc cgccttcccc     1260

gcatgtgccc tgggctggtg ggggccttgt ggtccctgga gctcagcagc tgttgatgtt     1320

tcaatgaagg gctactgggt gggggcacca gcctcgacgc tgcccagccc tgcagcactg     1380

agccctctcc cagagggacc ctgggactgc cacagggtgc tgagtgctgc tttgttctgt     1440

tcttgcttct aaaaccaatt cactcaccaa gacacgaggc gccggcagca gggctcggat     1500

tacacgtcca cctctgagga ggagtacggc tcccgccacg gctcccccaa acacacacgc     1560

tcccacacct caacagccac tcagaccccg agggctggca gctccagccg ggctcgttcc     1620

cgggcccccg gcccccggga cacggacgac gatgaggagg agcctgaccc ttatggtttc     1680

atcgtgcaga cggcagagat tgcggagatt gccaggctga gccagacgct ggtgaaggac     1740

gtggccatcc tagcccagga gatccacgat gtggctgggg acggtgacac actgggctcc     1800

tcggagcctg cccacagcgc ctccctcagc aacatgccca gcacccccgc ctcgaccatc     1860

tctgcccggg aggagctggt gcagcgcatc cccgaggcca gcctcaactt ccagaaggtg     1920

ccgcccggct cgctgaactc tcgggacttt gaccagaaca tgaacgacag ctgtgaggac     1980

gccctggcca acaagacgcg gcctcggaac cgagaggagg tgatcttcga taacctgatg     2040

ctgaacccgg tgtcccagct gtcgcaggcc atccgtgaga acacagagca ccttgccgag     2100

aagatgaaga tcctctttca gaacacaggg agagcttggg aggacctgga agccaggatc     2160

aacgccgaga acgaggtgcc catcctgaag acatctaaca aggaaatcag ctccatcctg     2220

aaggaactga ggcgggtgca gaaacagctg gaagttatca atgccatcgt ggaccccagt     2280

gggagcctgg acctgctcct ccccacactg agctcctttg ttcctccccc tccagccttt     2340

gcctgggaac tggtccttgt ttgccgggct tctcggaggg ttcactgtac attcgttctc     2400

aggtggtctt gtggctgtct ttcggaaaat ggttatttta tatgatttgt catggaattt     2460

gttctaataa atcattcttc tatc                                            2484


<210> 3090
<211> 395
<212> DNA
<213> Homo sapiens

<400> 3090
tgccaacaac gtcgaggcct gcacttgatg tcaagggtgg cacctcacct gcgaaggagg       60

atgccaacca agagatgagc tccgtggcct actccaacct tgcggtgaaa gatcgcaaag      120

cagtggccat tctgcactac cctggggtag cctcaaatgg aaccaagagc cctgctatca      180

tcgattcgga cccagtggat gaggaagtgc tgatgtcgct ggtggtggaa ctggggttgg      240

accgagccaa tgagcttccg gagctgtggc tggggcagaa tgagtttgac ttcactgcgg      300

actttccatc tagctgctaa tgccaagtgt ccctaaagat ggaggaataa agccaccaat      360

tctgttgtaa ataaaaataa agttacttac aaaga                                 395


<210> 3091
<211> 902
<212> DNA
<213> Homo sapiens

<400> 3091
aaatttgcgc gggttggagc ctggcgtagt catggccgcc ttccgcgaca tagaggaggt       60

gagccagggg ctgctcagcc tgctgggcgc caaccgcgcg gaggcgcagc agcgacggct      120

gctggggcgc cacgagcagg tggtggagcg gctgctggaa acgcaagacg gtgccgagaa      180

gcagctgcga gagatcctca ccatggagaa ggaagtggcc cagagccttc tcaatgcgaa      240

ggagcaggag cgacaggaga aggaggtcga cgaggacacg acagtcacaa tcccctcggc      300

cgtgtacgtg gctcaacttt accaccaagt tagtaaaatt gagtgggatt atgagtgtga      360

gccagggatg gtcaaaggca tccatcatgg ccccagtgtg gcccagccca tccacctgga      420

cagcacccag ctctccagga aattcatcag cgactacctc tggagtctgg tggacaccga      480

gtggtagcca ggagcctcgt ggctgcgtct tgcacccagc gggcatctgc cgtggtcaga      540

tccatttcaa atgaaatgtg gggacataga tctttttttt tttttttttg agacagagtt      600

tcactcttgt tgtccagtct ggagtgcaat ggcacaatct cagctcacag caacctctgc      660

ctcctgggtt caagcgattc tcctgcctca gcctccaaag tagctgggat tacaggcatg      720

cgccaccaca cccagctaat tttttgtatt tggtagagat ggagtttcac catggtggtc      780

aggctggtct tgaactcctg acctcaggtg atccacccgc ccgccttggc ctcccaaagt      840

gctaggattc caggcgtgag ccatcgtgcc cagctagacg tcttcctttt tttttttttt      900

tt                                                                     902


<210> 3092
<211> 524
<212> DNA
<213> Homo sapiens

<400> 3092
gggccatctg gccatgagca cttctctctc tgtctgccac gacagggggg acaggcccca       60

cctcggacac aggctggggc tgcatgctgc ggtgtggaca gatgatcttt gcccaagccc      120

tggtgtgccg gcacctaggc cgagattgga ggtggacaca aaggaagagg cagccagaca      180

gctacttcag cgtcctcaac gcattcatcg acaggaagga cagttactac tccattcacc      240

agatagcgca aatgggagtt ggcgaaggca agtccatagg ccagtggtac gggcccaaca      300

ctgtcgccca ggtcctgaag aagcttgctg tcttcgatac gtggagctcc ttggcggtcc      360

acattgcaat ggacaacact gttgtgatgg aggaaatcag aaggttgtgc aggaccagcg      420

ttccctgtgc aggcgccact gcgtttcctg cagattccga ccggcactgc aacggattcc      480

ctgccggagc tgaggtcacc aacaggccgt cgccatggag accc                       524


<210> 3093
<211> 3383
<212> DNA
<213> Homo sapiens

<400> 3093
cctcctgacg agaaccaagg cgtgtgggga cgcagggcct ctgcgtgtca gggagcagaa       60

cctgggccga gccctaggtg aaggggcggg gtggttggcc ctgagccaat catggctcgt      120

gacgactcgg ctcggccaat cagaagaagg gaggcctggc gctctcgggg cgggtgagaa      180

accgcccccc cttgcagctc cgcggccaac gccttcgccc aggggtagtt ggagcggtgc      240

aggttcccag gctccaggta ctgggcgcct tacgagctgg gaggtggtgc ctctcaccca      300

gctaattgct ctctagccct tggccttcac aggtgttggt gcctgccgtg aacgcattct      360

gacctgggcc gtatctgtct cccaagactt tgtgcctatg gttggggaca gagtgaggtc      420

gttgccttga cgacgacagc atgcggcccg tggtcctcct aagtgtgagc ttgcggcgga      480

ccgaggccca cctgcctccc tgcctgcttc gccctggact cgtgactgcg tccgcagaag      540

aaatcacaac agcgctggaa ttgctagttt gctaggcagc atcttttgga cctgcgaacc      600

atatgcattt cacctcaaat ttgtttccaa gttgaaaacc tttgggtctt tctatgcgaa      660

cggattgaag aaacgcaaaa agtttctacg gactttaaat taaaatggaa aaatatgaaa      720

acctgggttt ggttggagaa gggagttatg gaatggtgat gaagtgtagg aataaagata      780

ctggaagaat tgtggccata aagaagttct tagaaagtga cgatgacaaa atggttaaaa      840

agattgcaat gcgagaaatc aagttactaa agcaacttag gcatgaaaac ttggtgaatc      900

tcttggaagt gtgtaagaaa aaaaaacgat ggtacctagt ctttgaattt gttgaccaca      960

caattcttga tgacttggag ctctttccaa atggactaga ctaccaagta gttcaaaagt     1020

atttgtttca gattattaat ggaattggat tttgtcacag tcacaatatc atacacagag     1080

atataaagcc agagaatata ttagtctccc agtctggcgt tgtcaagcta tgcgattttg     1140

gatttgcgcg aacattggca gctcctgggg aggtttatac tgattatgtg gcaacccgat     1200

ggtacagagc tccagaacta ttggttggtg atgtcaagta tggcaaggct gttgatgtgt     1260

gggccattgg ttgtctggta actgaaatgt tcatggggga acccctattt cctggagatt     1320

ctgatattga tcagctatat catattatga tgtgtttagg taatctaatt ccaaggcatc     1380

aggagctttt taataaaaat cctgtgtttg ctggagtaag gttgcctgaa atcaaggaaa     1440

gagaacctct tgaaagacgc tatcctaagc tctctgaagt ggtgatagat ttagcaaaga     1500

aatgcttaca tattgacccc gacaaaagac ccttctgtgc tgagctccta caccatgatt     1560

tctttcaaat ggatggattt gctgagaggt tttcccaaga actacagtta aaagtacaga     1620

aagatgccag aaatgtttct ttatctaaaa aatcccaaaa cagaaagaag gaaaaagaaa     1680

aagatgattc cttagttgaa gaaagaaaaa cacttgtggt acaggatacc aatgctgatc     1740

ccaaaattaa ggattataaa ctatttaaaa taaaaggctc aaaaattgat ggagaaaaag     1800

ctgaaaaagg caatagagct tcaaatgcca gctgtctcca tgacagtagg acaagccaca     1860

acaaaatagt gccttcaaca agcctcaaag actgcagcaa tgtcagcgtg gaccacacaa     1920

ggaatccaag cgtggcaatt cccccactta cacacaatct ttctgcagtt gctcccagca     1980

ttaattctgg aatggggact gagactatac caattcaggg ttacagagtg gatgagaaaa     2040

ctaagaagtg ttctattcca tttgttaaac cgaacagaca ttccccatca ggcatttata     2100

acattaatgt gaccacatta gtatcaggac ctcccctgtc agatgattca ggggctgatt     2160

tgcctcaaat ggaacaccag cactgagaac cattttggtt ctgaactgga tgatgctctt     2220

gcacttgaga tgacatcttc ttgcagcaag agtgctgata tcccaagagg agagattcat     2280

ggttttgatc atttccttct gaactgcctg cattttctga ggaaggcctt ctagaagaag     2340

gaaagacaaa gacttccaaa tgtttcaaag gaagattgaa caaatggccc tccccaactg     2400

ttatcccatt acctttcacg tccaccgatg ctatttcaag acatatccag tggaataaca     2460

gtgatatggt tcttgttaca tgaatgtgta tttactgtta ggagattgta tattttaagt     2520

taccatgatt aaaagtgtgt aaaaaagggg gacagagaga aatactataa aaggccatgt     2580

tactcatgca ttgaactttg tgtgttttct gtataaatgt gtacatttat ttaggagtgg     2640

gtttcttggg ggtaggtgat aaaaattagg atcagttgaa gaaaattgaa gaaactagga     2700

tcagtaagag aaactgtttg ctttacctga atttaactat gaaaacacac ttaacaatct     2760

tacacgtttc tagatattaa gtgaatatgt aactcctgtc catgggtaga tgtgtatctt     2820

tgacttctgt aattattttt gatattctat cagtgtatta tgagactctg gcctccctgc     2880

agatcttcta agaaccacac taatgcaagc gtgacagaga aacctctttc gaatgactta     2940

ctacaactct ggcattggtt agttccatgt attgtaagat tctggtgcta atgctccata     3000

cagaattgat caggactgat tactcttctg tggaccaatt gctattgaac tacccagctg     3060

aagagggttt ggggagagaa cgttcattat tatggactcc acttttgtcc cctggtagtt     3120

taagggtgat actagaatcc agagaagttc ctgtctcctt gtggcctcaa acactcaggc     3180

cgtctcaaaa gcttttcacc aaggtgcaaa atcatttacc tgcattccac acatcttttc     3240

caatgcatgg atccaaaact ttttaggtgg gaggaataaa ctaagttggc tacaggttct     3300

tgatttctgg gtttctacac atgctctgca tttatcattt tagagaatgg ttgtttaggg     3360

aaccagaatt tgtgagtttt ttt                                             3383


<210> 3094
<211> 6455
<212> DNA
<213> Homo sapiens

<400> 3094
agggggcaga gtgtcctcac caaaataaga cagttttgca catggatgga tgtttagaca       60

ctgagactcc tacggtgtcc attcaagaaa atgtggatgt agcctctttg aagcccatta      120

gtgacagtgg aattaatttc actgatgcca tttggtcacc aacttgtgaa aggcgaacat      180

gtgaatgtca cgagtccatc gaaaagaata aagacaaaac agatctccca cagagtgtgg      240

tctatcaaaa tgaagagggt aggtgggtca cagaccttgc ctattacaca tcttttaata      300

gcaaacaaaa tttaaatgtg tctctaagtg atgagatgaa tgaagacttc agatctggtt      360

ctgaagcatt tgatttgatt gcacaagatg aagaagaatt taataaagag catcaattta      420

tacagccatc atttggctat tttattagat caccagagaa gagagaacct attgccttaa      480

taagaaaatc tgatgtatca agaggtaatt tggaaaaaga aatggctcat cttaaccatg      540

atctatattc aggagattta aatgaacagt cccaggcaca gctaagtgaa ggatcaatta      600

cacttcaggt tgaagcagta gagagtactt cacaagtgga tgaaaatgat gtgacgttaa      660

cggctgataa aggcaaaaca gaggacactt tcttcatgag caacaaaccc caaagataca      720

aagacaagct accagatagt ggtgattcta tgcttaggat cagcaccatt gcttcagcca      780

ttgcagaggc atcagttaat actgatcctt cccaacttgc tgcaatgatc aaggcacttt      840

caaataaaac cagagacaag acttttcagg aagatgagaa acaaaaggac tattctcatg      900

tgcgtcattt cttacctaat gatttagaaa aaagtaatgg atccaatgca cttgatatgg      960

agaaatacct taaaaaaaca gaagttagta gatatgaaag tgcattggaa aacttttcaa     1020

gggctagtat gtctgatact tgggatttat ctttgcccaa agaacaaact actcaagaca     1080

ttcatccggt ggacttaagt gctactagtg taagtgtgag ggcaccagaa gaaaacacag     1140

cagctattgt ttatgttgaa aatggagaga gtgagaatca agagtcattt agaaccataa     1200

actcctcaaa ttcagttaca aatagagaga ataacagtgc agtagttgat gtgaagacat     1260

gttccattga caacaaatta caagatgttg gtaacgatga aaaagctacc tcaatttcca     1320

ctccatctga tagttattca tcagtgagga accccagaat aacatccctt tgtctgttaa     1380

aagactgtga agaaatacga gataacagag aaaatcagag gcaaaatgag tgtgtcagtg     1440

aaataagcaa cagtgagaag catgtgactt ttgaaaacca tcgcatagtc tcacctaaaa     1500

atagtgattt gaaaaatacc tctcctgagc atggtggacg tggctcagag gatgagcagg     1560

agagcttcag accttccacg tcaccactga gtcattcttc tcctagtgaa atttctggaa     1620

cgagttcatc agggtgtgcg ttagagtcct ttggttcagc agctcagcag cagcagcctc     1680

cctgtgagca ggagttgtct cccttggtgt gctcgcctgc tggggtgagc aggctgacgt     1740

atgtgtctga accagagagc tcctatccta ccacagccac agatgatgcc ctggaggacc     1800

gcaagagtga tatcaccagc gagttgagta ccacaattat tcaaggcagt ccagccgcat     1860

tggaggaacg ggctatggaa aaattgagag aaaaagttcc atttcagaat agaggaaaag     1920

gaacattatc atctattatc cagaataact ctgatacaag aaaagcaact gaaactactt     1980

ctctgagtag caagcctgaa tatgtaaaac ctgactttag atggagtaaa gatccttcct     2040

ccaaaagtgg aaatctgttg gaaaccagtg aggtaggttg gacatcaaac cctgaggaat     2100

tggacccgat caggctggct ctcctgggca agtcaggtct gagctgtcag gtggggtcag     2160

ccacatcaca ccctgtgtcc tgccaggagc ctatagatga agatcaaaga ataagtccta     2220

aagataagtc aactgctggc cgtgagttca gtggccaggt ttctcatcag accacctctg     2280

aaaaccagtg tactcctatt cccagcagca cagttcacag ctctgtggct gacatgcaga     2340

acatgcctgc tgctgtgcac gcactcttga cacaaccctc tctcagcgct gctccttttg     2400

ctcagcggta tttgggaaca ctcccttcaa ctggaagcac caccttgcct cagtgccatg     2460

ctggcaatgc cacagtctgt ggcttctcag gaggccttcc ctatccagct gttgcaggag     2520

agcctgtgca gaactctgtg gctgtgggaa tttgtctagg atcaaatatc ggctctggat     2580

ggatgggtac ctcttccctc tgtaacccat attctaatac cttaaatcag aacctgctaa     2640

gcacaacaaa accttttcct gtgccgtctg ttggtacaaa ctgtggaatt gaaccatggg     2700

attcaggagt gacatcagga ttggggagtg tccgagtgcc cgaggagttg aagcttcctc     2760

atgcttgctg tgtcgggatc gcttcccaga ccctcctcag tgtgcttaat ccaactgacc     2820

gctggctgca agtcagcatt ggggtcctca gcattagtgt taatggtgaa aaggtggatc     2880

tttcaacata tcgttgttta gttttcaaga ataaagccat cataagacct catgccacag     2940

aagagataaa agtgcttttt ataccatcca gtcctggggt tttcagatgc acattcagtg     3000

ttgcttcttg gccatgttcg acagatgctg agaccatcgt acaggcagaa gctttggcca     3060

gcaccgtcac tctcactgcc attgccgaga gtcctgttat tgaggtagaa acagaaaaga     3120

aagacgttct tgattttggt gacttgactt atggaggctg gaaagccctc ccactaaaat     3180

tgataaaccg aacgcatgcc actgtgccaa ttagactgat tattaatgct aacgctgtag     3240

cctggcgctg tttcacgttt tccaaggaat ccgtccgagc tcctgtggaa gttgctcctt     3300

gcgctgatgt ggtcactcgg ctagcaggcc cttctgtggt caaccacatg atgcctgcta     3360

gttatgatgg acaggatcca gaatttctga tgatttgggt tcttttccat agtccaaaga     3420

aacagatcag ctcttcagat attctggact cagcagaaga attctcggca aaagttgata     3480

tcgaagttga cagcccaaac cctacgcccg ttcttagaag tgtgagtctc cgagcaagag     3540

caggaatagc taggatccat gctcccaggg acttgcagac gatgcatttc ttggccaaag     3600

tggcttcctc aagaaagcag cacttacctt tgaaaaatgc tgggaacatt gaagtttatt     3660

tggatatcaa ggtcccagaa caaggaagtc acttttcagt ggatccaaag aatctactcc     3720

ttaaacctgg agaagaacat gaggttattg tttcatttac tccaaaggat cctgaagcct     3780

gcgaggaaag gatcttgaaa atatttgtgc agccatttgg acctcagtat gaggtagtgt     3840

taaaaggcga agtcatttct tcaggaagta aacctctgtc acctggacct tgcttagata     3900

ttccatcgat tttgtccaac aaacaatttc tggcttgggg aggagtccct ctaggtagaa     3960

cacagcttca gaaactagct ttaagaaata attctgcatc tacaactcaa catttacgac     4020

tgcttattag aggacaagat caggactgct ttcagcttca gaacactttt ggttcagaac     4080

agcgattgac cagtaactgt gagatcagaa ttcacccaaa ggaagacatt ttcatctctg     4140

tattatttgc acctactcga ttatcttgca tgttggctag actagaaatc aaacaacttg     4200

gaaatcgatc acaaccaggc attaagttca caataccttt gtctggatat ggaggaacaa     4260

gcaatcttat tttggaaggc gttaaaaaat tatctgacag ttacatggta acagtgaatg     4320

gcttagtacc tggcaaagaa agtaaaattg ttttttctgt ccgcaacact ggctcccgag     4380

cagcttttgt taaagcagta ggttttaagg attctcagaa aaaagttttg ctggatccta     4440

aagtattgag gatttttcca gataaatttg tactcaagga aagaacacaa gaaaatgtta     4500

ctttaatata taatccatca gacagaggaa tcaataataa aactgcaaca gaactatcaa     4560

ctgtatactt atttggtgga gatgaaattt caagacagca gtatcgcagg gccctgttac     4620

ataaaccaga gatgataaaa cagatacttc cagaacatag tgtgcttcaa aacattaatt     4680

ttgttgaagc atttcaagat gagctattag taactgaagt atatgatctt ccccaacgac     4740

ctaatgatgt tcagctcttt tatggaagca tgtgtaaaat tatactttca gtaattggag     4800

aattcagaga ttgcatttct agcagagaat tccttcagcc ttcttccaaa gctagcttgg     4860

aatctacaag cgacttggga gcttctggga aacatggtgg caacgtctct ttggatgttt     4920

taccagtcaa aggtcctcag ggttctcctc ttctctcacg ggcggctcgc ccgcctctgg     4980

atcagctggc ctccgaagag ccgtggactg tcctacccga gcacttgatt ctggtagctc     5040

cttctccttg tgacatggca aaaactggac gtttccagat tgtgaataac tctgtgaggt     5100

tactgagatt tgagctgtgc tggccagcgc attgcctcac agtcacgccg cagcatggat     5160

gtgtcgcgcc agagagtaaa ctacaaattc ttgtgagtcc taattcctcc ttatccacaa     5220

aacagtcaat gttcccgtgg agtggtttga tctatataca ctgtgacgat ggacagaaga     5280

aaattgtgaa agttcaaatt cgagaagatt taactcaagt ggaactttta actcgtttga     5340

cctccaaacc atttggaatt ctttccccag tatctgagcc ttcagttagt catttggtca     5400

aaccaatgac aaaaccgcct tccacaaaag ttgaaataag aaacaagagt attacttttc     5460

ctacaacaga acctggtgaa acttcagaga gctgtctaga actcgagaat catggcacca     5520

cagacgtgaa atggcatctg tcatctttag cgccacctta tgtcaaggga gttgatgaaa     5580

gtggagatgt ttttagagct acctatgcag cattcagatg ttctcctatt tctggtctgc     5640

tggaaagcca tgggatccaa aaagtctcca tcacattttt gcccagaggt aggggggatt     5700

atgcccagtt ttgggatgtt gaatgtcacc ctcttaagga gcctcacatg aaacacacgt     5760

tgagattcca actctctgga caaagcatcg aagcagaaaa tgagcctgaa aacgcatgcc     5820

tttccacgga ttccctcatt aaaatagatc atttagttaa gccccgaaga caagctgtgt     5880

cagaggcttc tgctcgcata cctgagcagc ttgatgtgac tgctcgtgga gtttatgccc     5940

cagaggatgt gtacaggttc cggccgacta gtgtggggga atcacggaca cttaaagtca     6000

atctgcgaaa taattctttt attacacact cactgaagtt tttgagtccc agagagccat     6060

tctatgtcaa acattccaag tactctttga gagcccagca ttacatcaac atgcccgtgc     6120

agttcaaacc gaagtccgca ggcaaatttg aagctttgct tgtcattcaa acagatgaag     6180

gcaagagtat tgctattcga ctaattggtg aagctcttgg aaaaaattaa ctagaataca     6240

tttttgtgta aagtaaatta cataagttgt attttgttaa ctttatcttt ctacactaca     6300

attatgcttt tgtatatata ttttgtatga tggatatcta taattgtaga ttttgttttt     6360

acaagctaat actgaagact cgactgaaat attatgtatc tagcccatag tattgtactt     6420

aacttttaca ggtgagaaga gagttctgtg tttgc                                6455


<210> 3095
<211> 7948
<212> DNA
<213> Homo sapiens

<400> 3095
gcgcggcagc cgggccttgc tccgggacgt gtttatttgt aacttagtgc tttttatcgt       60

cttaaggagg tatttggtgg aggctctttg aagttgggtt caggagtgta gaattggcaa      120

agttattgcc agcttcctgc atcaacaaca gcaacttgtg attggcggtg accggatatt      180

cagttgcaca tccccacatc aatgcactgc caatgggtta tatcctgtgt tgtgacctca      240

tggtttaagt gggaataaag atgagtataa gcagtgatga ggtcaacttc ttggtatata      300

gatacttgca agagtcagga ttttctcatt cagcatttac ctttggtata gaaagccata      360

tcagtcagtc caatataaat ggtgccctcg tcccacccgc tgcattgatt tctatcatcc      420

agaaaggtct acagtatgta gaagcagaag ttagtattaa tgaggatggt accttgtttg      480

atggtcgacc aatagagtct ctgtccctga tagatgccgt aatgcctgat gtagtacaaa      540

caagacaaca agcttataga gataagcttg cacagcaaca ggcagcagct gctgcagctg      600

ccgcagctgc agccagccaa caaggatctg caaaaaatgg agaaaacaca gcaaatgggg      660

aggagaatgg agcacatact atagcaaata atcatactga tatgatggaa gtggatgggg      720

atgttgaaat ccctcctaat aaagctgttg tgttgcgggg ccatgaatct gaagttttta      780

tctgtgcctg gaaccctgtt agtgatctcc tagcatcagg gtctggagac tcaacagcaa      840

gaatatggaa tcttagtgag aacagcacca gtggctctac acagttagta cttagacatt      900

gtatacgaga aggagggcaa gatgttccaa gcaacaagga tgtcacatct ctagattgga      960

atagtgaagg tacacttcta gcaactggtt cctatgatgg gtttgccaga atatggacta     1020

aagatggtaa ccttgctagc accttagggc agcataaagg ccctatattt gcattaaaat     1080

ggaataagaa aggaaatttc atcctaagtg ctggagtaga caagactaca attatttggg     1140

acgcacatac tggtgaagcc aagcaacagt ttccttttca ttcagcacca gcattggatg     1200

ttgattggca gagcaacaac acctttgctt cttgtagtac agatatgtgc attcatgtct     1260

gtaaattagg acaagacaga cctattaaaa cattccaagg acatacgaat gaagtaaatg     1320

ctatcaaatg ggacccaact ggcaatctct tggcctcctg ttctgacgac atgactttaa     1380

agatatggag tatgaaacaa gacaattgtg tccatgattt gcaagcacat aataaagaaa     1440

tttatactat caaatggagt ccaacaggac cagggactaa taatccaaat gccaacctta     1500

tgttagcaag tgcatccttt gattctactg ttaggttatg ggatgtagac cgagggatat     1560

gcatccatac cttgacaaaa caccaagagc ctgtgtacag tgtagctttc agtcctgatg     1620

gcaggtatct ggcaagtggt tcttttgaca aatgtgtaca catctggaac acgcagacag     1680

gtgctctagt tcacagctat aggggaacag gtggaatatt tgaagtttgc tggaatgcag     1740

caggagacaa agttggagcc agtgcatcag atggttcagt ttgtgtatta gaccttcgga     1800

aatagcgcta ctagttggaa gccatggacc gactatgaat gtgtacatag ccaaaatgac     1860

tgtccctgac ccatgtactg ctatagtccc acttgaacca tggccagtcc actacagcca     1920

aatctaaaag aaatatatac atacagtgta tataaacaaa attgcaccct gaagatgaca     1980

gagttttgtc acagcttgtg aattctgttc accaagtgct ggaatctaat ctgctgtgcc     2040

cctaaaatag catttagaag ttttggatat gaaaaacaga agagagaaaa atatacatta     2100

taaaagcaga acatacatgt accagttttt ggatactaaa tgacagcctt gtttctcccc     2160

tttgaatcag cagacaccat ggattatatt ctttttttcc cttcagtagt gagcagtttg     2220

tatgtacaga gaaaatggac ttacaaaaac ttgcagcagt agtttgttct tgctttaaaa     2280

tttcgttttt ggtttagatt atggatgcat gaagtaaggg agtgaatcag tttcttgttt     2340

atattttttt caccttttaa acaaaaaatt ctttaaaata ttttaatgca ttcttttgaa     2400

gaggtagatg tttggtacat tttatggctc ccagagcata tattcagttg gtgcatgttg     2460

tggaaggggg aattggaaat taaatgaaaa cctatgactt tggtcatgtc aatctgtaag     2520

acacatcagt aaaagggtat tatgctctgt tggttttgtt tttttgtttt gctttttttt     2580

tttttttttc ttttttgttt tttggtgatg tggcttaaat gcaatagttt cttttttggg     2640

acatatttct gccaattaaa gactagaagg gcacaacttt ttttttaatt accatagaga     2700

agatacatta aaaaaaatct tctgatgttt tgtagccata actaaattat ggtaaaaatg     2760

tgcactattg tgaaaaggag caacgtagtt ttgggttttt tgttgtttgt ttgttttgct     2820

ttgtttttta agagattaaa atgtttctgg ataaggatta gcttctcgaa gtgtccatca     2880

ttctgtgtag aagcttaaat atgtaatgta accaaactcc agtattaaaa atctctcatg     2940

ttgttttctt tatacaaagc aagataacgg catataacac tgccattaca tggcaaaatg     3000

tttgctacct tagtttaaaa aacaatctca aacaaaagac ttgcttcaag gtgtttttaa     3060

atagcagtga ttcagaattt tttttaatga aagtataatt gcactaacct tcttcctgct     3120

gctctgattc tgcatttgtg gtacttgtga ctacgttttt tcaaatatag atagatttaa     3180

gctgctaatt tttttttttt tagtaatcac tactatatca tgtcttttac tctgtttata     3240

atatcaagta ttttcttaaa gatatagata ttaaaccttg tgctcatgca acttagagta     3300

acatatacag acaaatgatt gcatgaggcc atgtttatat gtgtgactaa taaggcttgt     3360

catgattaac ataatccagg tatgtcattt ctgaagagaa tagtcatcaa atttatatct     3420

cgaagatttt aattaaggaa ttgcttattg ttgagcttag caaattaata acactatttc     3480

tgtcactaat tattttgagg ccttttagta ctaaaatttt aacctgtgtt ctaagtagaa     3540

actgatttaa cccaagtaat gcagctttga ttgatttcag cattcgttgc tttgctattt     3600

ttacaaaaca gcattgattg aagcaagtct tggttttact aaggtagggt agcatttgct     3660

attggtaaag agaataaata cacttaattt cacaatacat tgttatatgt accccagttg     3720

ttgttagtgg ggactatgat actgtaataa tatttttaaa aatttacatc aagagaggca     3780

gtcattcacg atggttttgt gccagctctt tttagggttt tggatcacat tagagatatt     3840

tagaacatat taccctgtga cttacgtagg aaacctaata tgctgagtat ctggcacttg     3900

aattcctgct tttattgctg gaggtccaca tctgtggttg acctctgtta ttgtttaaaa     3960

aaaataaata aaaattaaaa aaatctgtgc aataatttta aaatgtgctc ccaggaatag     4020

acacaaatgt tttgagtatc ttttaagctg cattttcctt tagtgatgca tttgtcaatt     4080

gcactgaatt taaatctgaa agtcagaggt gattattgat agtacttttg tattttgata     4140

tggacagttt attcatttgc atacagttat tgactttttc ccagctgatt aaaagatagt     4200

caagaaattc tgcaatatag ctgccaaaat agacagctac atttttatga tattgtcatc     4260

ttttctgttt tttttttctt ttttttcttt agctatttta cttaagcata atagccacaa     4320

taggacatat aaaagattat aaatacagag ctttattatc ctgacgtctt gggtctttta     4380

agtatatact tttctgaaag gtatccattt tgtaggcttg ggttcttcat gagcatacga     4440

ttgtttattt ttgctgctgt tctcaacatc atcattgcct gctgatgtgc cacgatgctg     4500

ctccaataga cagcaataag attgtctcta atttgagcag taacatgatt gcaagagacc     4560

aagtttcaca gcttgtaaag ttctgtattt gggattcttg cttatttttc cgcctgtgtt     4620

tttctgagaa cttattcctg atgatcaatt gaatccagta gtttttctat gctatttgtt     4680

gttgtataag ctactgtaag aaacttatca taaggaaaaa tagaaaggaa aacttgaatc     4740

aatactcatt gattaaaatg gaataaagaa agagcagctg ccacttttaa acaacataaa     4800

ggaatatctt tttttgtctc cgtgtaggaa atcccataag ttcttatatt tgttccagtt     4860

cccatttcct gccattgacc agataacatc attgactttc aaatgacttt tagaagtgat     4920

aactcttaat ttcctaatag atactagatt gtattgaatt ctgttttaat tattctctag     4980

gtaagtatgt tttaggatta aatacctttt acagatactg aaagtgcctc cttttgtggt     5040

gtaaaaaaca aattatggtg caaaaagtaa tcactagatt gaaatacatg aaggtttttt     5100

gctttttgac atacgaaaat gtcaagagaa aggccaaaga tttgtacttt ttcacttaca     5160

aagcactcct ttttccctta aacttctttc tgtcaaatta gatttaatga gagagtacta     5220

tttttaagga gctatctgtt tatgtagaat gattttgtta agagtaatgt aaactattat     5280

tgagtagagg cctaaagagg actgtgcatt tttgctattt aaaggaatca caaatgatca     5340

tacttaagtg agcaaaaatg acaagtttta ctagctaagt agagaaataa atctcaaatg     5400

cagcgctaca attttcatta tcttaagtac attgtacatt tctacagaac ctgtgattat     5460

tctcgcatga taaggatggt acttgcatat ggtgaattac tactgttgac agtttccgca     5520

gaaatcctat ttcagtggac caacattgtg gcatggcagc aaatgccaac attttgtgga     5580

atagcagcaa atctacaaga gaccctggtt ggtttttcgt tttgttttct ttgttttttc     5640

ccccttctcc tgaatcagca gggatggaag gagggtaggg aagttatgaa ttactccttc     5700

cagtagtagc tctgaagtgt cacatttaat atcagttttt tttaaacatg attctagtta     5760

aatgtagaag agagaagaaa gaggaagtgt tcactttttt aatacactga tttagaaatt     5820

tgatgtctta tatcagtagt tctgaggtat tgatagcttg ctttatttct gcctttacgt     5880

tgacagtgtt gaagcagggt gaataactag ggcatatatt tttttttttt ttgtaagctg     5940

tttcatgatg ttttctttgg aatttccgga taagttcagg aaaacattct gcatgttgta     6000

tctagtctga tgtacttatc catctcatta caaacaaaaa cacacagact gcatttgtag     6060

ctctgtaatc cttgaatacg gaagtaaatt ttcttctttc ctgactttga cattgtagct     6120

atactgtttc catttttgtt tttacaaatc ctttgggtct aattctgtga gcctacctat     6180

agcactggat taaaatgtct gcatcatttc tttagttatc cagttaactt taaaactgtt     6240

gtaaaagtgt aaaccagccc atgacaggtt tttgtacatg ttaaagaact tcattgttca     6300

gttttcatga ttattgtgta aggaagactg atgtagatgt tctgtgctgt cctggaccat     6360

gttaattaca cttacgacgt attttagttc cacatcacaa tgatttgtcc ccagtgaccc     6420

ttttatcctt tctaggcaca tttcttgttg ttgttgttgt tgcagttccc ctttgcattg     6480

tattgctttg acaactgtaa tttgaatcag atctgaaaga ggtccagaat aaaatatatt     6540

ttgatattat gttggctgtg tacatatata aaacctttga tgtctatgta gtttatatag     6600

actatttact agtcaggtaa agagagaggg atggtatttc ttgtttacag tttgtttaca     6660

ttttaattgc ttttacttct ccagtgttct attgtagaat aaaccttttt ttccaagtta     6720

gccttcataa cctataacac attcattctc tcccatactg gtgttactga ttaataactg     6780

ccatcagaac ccaaaccact gtttttcata aacgtattgt ttcccaagat atatacttta     6840

agcccataat aaaattacaa attttactat ttttattact tcttgcagga gataagattt     6900

ttttaaatga aggggttatt tactattttt attaaagtat aatagagcat ctaatcagct     6960

aagggattgt aatttttaat tcttttgaaa aataaatatt gtatttaaaa gacgttattt     7020

cacagaagct gaaaaagaga ccttagataa catttgtttg gttagccaca cggttgagca     7080

caaaacaatg tgtagatgtg ttgaagatta gggcaggagg ctcaacttct cggtgacctt     7140

tttttgcttc acaacaagcc aattatagtt gaatcatttt ctctcttagc tagttgttac     7200

tacaaacttt ataagaaaaa caactagaca ccttctagtt ttaattaata ccaactcctt     7260

tagagttaga gactttttaa aaagaatcat tgagcatatt ttcttttttt tttttttaag     7320

aatttacact ctctaggtct tctatttttc ctgtttattt ccttaaacag aaataaattc     7380

aagcatagtt ttatgtttta ttagaaataa gccactgcag ttgctagaac tgacatgctt     7440

tcattttcaa ggggttaact tttattgcat ggcatagatt attagtaata tcctgcattg     7500

tatacttttc caaaaagggt tggactccta aggattagaa tccttataag cttgagggaa     7560

agctgaaact aatttgaaca gtaatagaag ggattatttt taatttcata gttaacactt     7620

tacaatggat tagatttatt acctagtata atccgtagca gatcagatca aagtttactg     7680

ttttaccaat atattcattt gaaaaaatac agtggaggaa aagacacttt agatggtagt     7740

tttatggtgc ttttctctgc tgtaccaaag tgctttgtca tcaatgaaat gttaacccta     7800

tgctactttt tctgcatgct tcttaaatgt catcttaatg cttaattgtc ctaacttgta     7860

atatttttgt attaaatttt tttaggagtt ccttgtaatt tctttacaat ttaaaatata     7920

ttaaacacaa agtgtttagt aaagtaca                                        7948


<210> 3096
<211> 2335
<212> DNA
<213> Homo sapiens

<400> 3096
aaaatgctcc cgccgacgca cagcagtgac gacacacaag gtttcgggga ctgagtgggt       60

ttcagacttt ctctcaggat ttccgctggc ttcaggttcc ggtcaggcgt cgggacagag      120

cctgatccag gcttcggcgg ccggtggcag ctctcgatca gctctcgcag tcggagaggc      180

ggctaaggaa aggtgccaca gcagagacgc gaaggagagg ccctagaacc ttttcaaaga      240

agaatggaag aaaccatgaa gcttgctacg atggaagaca cagtggagta ctgcctgttc      300

ctgataccag atgagtcaag ggactcagat aaacataaag agattcttca gaagtacatt      360

gagagaataa tcactcggtt tgcacctatg ctggtcccct acatctggca gaatcagcct      420

ttcaatctta aatataaacc tgggaaagga ggtgttcctg ctcatatgtt tggcgtgaca      480

aagtttgggg ataacattga ggatgaatgg tttattgttt atgtaataaa gcagatcaca      540

aaggaatttc cagagttagt agcaaggatt gaagacaatg atggtgaatt cttgttaata      600

gaagctgctg actttctccc taaatggctg gatcctgaaa atagcaccaa tagggtattt      660

ttctgccatg gggaattgtg tattatccct gcaccaagaa aatctggagc agaatcttgg      720

ttacccacca cacccccaac aattccacaa gcattgaata taatcacagc acattcagaa      780

aaaatacttg cttcagaatc tatacgagct gctgtgaata ggcgcatcag agggtaccca      840

gaaaaaattc aggcctcact tcatcgagca cactgcttcc ttccagctgg cattgtggca      900

gtgctaaagc agcgccccag attggtggct gcagcagtcc aggcatttta cctacgagac      960

cctattgacc tgcgagcttg tcgtgttttc aagacattct tgcctgaaac acgaataatg     1020

acatcggtca cattcactaa atgtctatat gcacaattgg tgcaacaaag gtttgtgcca     1080

gaccggcgga gtggatacag gctgcctcct ccatctgatc cccagtaccg agcccatgaa     1140

ttgggcatga aattggctca tggatttgag atcttatgct ccaaatgtag cccacatttt     1200

tctgactgca agaaatccct tgtgactgcc tcaccactct gggccagttt ccttgaaagt     1260

ctgaaaaaga atgattactt taagggactg atagaaggtt ctgctcagta ccgggaaagg     1320

ctagaaatgg cagagaatta cttccagctc tcagtagact ggccagaaag gttggaggtg     1380

cagtggcgcg atcctggctt actgcaagct ccacctcctg ggttcacgcc attcatctgc     1440

ctcagcctcc tgagtacctg ggacaacagt tctcttgcta tgagccctgg tgaagaaatc     1500

ttaaccttat tacagacaat accatttgat atagaagacc ttaagaaaga agcagctaat     1560

cttcccccag aggatgatga ccagtggtta gatctctcac cagatcagct ggaccagctg     1620

ctgcaggaag ctgttggcaa aaaagaatcc gagtctgttt ccaaggagga gaaggagcag     1680

aactatgact taactgaagt ctcagagagc atgaaagctt tcatatccaa agtctcaacc     1740

cacaagggag cagagctgcc tcgagaacct tctgaggctc caatcacttt tgatgcagat     1800

tcttttctta attattttga taagatttta gggccaaggc ctaatgagtc agattctgat     1860

gatctggatg atgaagactt tgaatgttta gatagtgatg atgacttgga ctttgaaaca     1920

cacgaacctg gcgaagaggc ttccctgaaa ggaacacttg ataatctcaa gtcatacatg     1980

gcccagatgg accaggaact agcacacacc tgcatcagca aaagtttcac cactaggaac     2040

caagtggaac ctgtatccca gactaccgat aacaattcag atgaggaaga ttctggtacg     2100

ggagaatctg ttatggcacc agtagatgta gacctgaacc tggtttcaaa tatattggaa     2160

tcctatagct cccaagctgg actggcagga cctgcttcca atcttttaca aagcatggga     2220

gtgcagctgc ctgacaacac cgatcacaga ccaacaagta agccaacaaa aaattaacca     2280

gcacatttag cttctctttt ttctttttaa ataaatattg aatatgattc tgttc          2335


<210> 3097
<211> 2706
<212> DNA
<213> Homo sapiens

<400> 3097
gtgaaaggtg aggggaacag ctgatccgtc tgttgggagg acagatatct caaggccagg       60

atggaagaat caccactaag ccgggcacca tcccgtggtg gagtcaactt tctcaatgta      120

gcccggacct acatccccaa caccaaggtg gaatgtcact acacccttcc cccaggcacc      180

atgcccagtg ccagtgactg gattggcatc ttcaaggtgg aggctgcctg tgttcgggat      240

taccacacat ttgtgtggtc ttccgtgcct gaaagtacaa ctgatggttc ccccattcac      300

accagtgtcc agttccaaga gccaaggccc atggatgaac tggtgaccct ggaggaggct      360

gatgggggct ctgacatcct gctggttgtc cccaaggcaa ctgtgttaca gaaccagctc      420

gatgagagcc agcaagaacg gaatgacctg atgcagctga agctacagct ggagggacag      480

gtgacagagc tgaggagccg agtgcaggag ctcgagaggg ctctggcaac tgccaggcag      540

gagcacacgg agctgatgga acagtacaag gggatttccc ggtcccatgg ggagatcaca      600

gaagagaggg acatcctgag ccggcaacag ggagaccatg tggcacgcat cctggagcta      660

gaggatgaca tccagaccat cagtgagaaa gtgctgacga aggaagtgga gctggacagg      720

cttagagaca cagtgaaggc cctgactcgg gaacaagaga agctccttgg gcaactgaaa      780

gaagtacaag cagacaagga gcaaagtgag gccgagctgg agcccttgaa ggagcagctt      840

cgaggggccc aggagcttgc agcctcaagc cagcagaaag ccacccttct tggggaggag      900

ttggccagtg cagcagcagc cagggaccgc accatagccg aactacaccg cagccgcctg      960

gaagtggctg aagttaacgg caggctggct gagctcggtt tgcacttgaa ggaagaaaaa     1020

tgccaatgga gcaaggagcg ggcagggctg ctgcagagtg tggaggcaga gaaggacaag     1080

atcctgaagc tgagtgcaga gatacttcga ttggagaagg cagttcagga ggagaggacc     1140

caaaaccaag tgttcaagac tgagctggcc cgggagaagg attctagcct ggtacagttg     1200

tcagaaagta agcgggagct gacagagctg cggtcagccc tgcgtgtgct ccagaaggaa     1260

aaggagcagt tacaggagga gaaacaggaa ttgctagagt acatgagaaa gctagaggcc     1320

cgcctggaga aggtggcaga tgagaagtgg aatgaggatg ccaccacaga ggatgaggag     1380

gccgctgtgg ggctgagctg cccggcagct ctgacagact cagaggacga gtccccagaa     1440

gacatgaggc tcccacccta tggcctttgt gagcgtggag acccaggctc ctctcctgct     1500

gggcctcgag aggcttctcc ccttgttgtc atcagccagc cggctcccat ttctcctcac     1560

ctctctgggc cagctgagga cagtagctct gactcggagg ctgaagatga gaagtcagtc     1620

ctgatggcag ctgtgcagag tgggggtgag gaggccaact tactgcttcc tgaactgggc     1680

agtgccttct atgacatggc cagtggcttt acagtgggta ccctgtcaga aaccagcact     1740

gggggccctg ccacccccac atggaaggag tgtcctatct gtaaggagcg ctttcctgct     1800

gagagtgaca aggatgccct ggaggaccac atggatggac acttcttttt cagcacccag     1860

gaccccttca cctttgagtg atcttactcc ctcgtacatg cacaaataca cactcatgca     1920

cacacacact cacacacatg catacactta ggtttcatgc ccattttcta tcacactggg     1980

ctccatgata ttctgttccc taagaactgc ttctgtgtgc cctgttttca tcccaagatt     2040

tctcacttca tcctctccta cctggctctt ttgtcccagg gaggggtcct gttcggaagc     2100

agtggctgaa tttatcccct gaaagtggtt ttggaggaac cgggatggag gaggccttcc     2160

cctgtgggaa tagaatcgtc cactcctagc cctggttgct tctgatacac agccactgca     2220

cacacacact cacactcaca ctcccttgtc tgatgcccca aagccaattc ctggggcacc     2280

ctaccctctc ttatttggag tttccgttgg tttacctgag ttttctctgg ggtctgcaca     2340

gaggcagcag catggacatc atggcctctc aggtcccttt tggttctcag tttcattggt     2400

tcctctttct gttcccccat tgacttctgt gccccaccct agccttttcc ataaccttag     2460

gtattcagtt tggaggggtt ttttgtattt ttgaggattc ctgtattctg tatcctctcc     2520

tcgcatctcc tcacatggaa agaaataatg tatttgtgcc ttctgtgagg aatgggggga     2580

acaagtggtc ccaggtatcc ccatttccaa ggcccccctc cctctccagg tccccccaca     2640

gcaataaaag cttccccctg atatccatcc ctttgtagtt tgaacaaata tatttatatg     2700

atatgt                                                                2706


<210> 3098
<211> 3452
<212> DNA
<213> Homo sapiens

<400> 3098
aaagcgttac ttccggcgga aaaggacgcg ggagattcga ttggaaggct gccggcgtgc       60

tactgagttc ggccggtccg agtcactgtg cgtcgcctgg gcccgttcct ggtcttctcc      120

cccagggtct tgctctgtca cccaggctgg agtgccatgg catcatcata gctcactatg      180

gccttgatcc tcctgcctta gcctcccaag cagctggtat tacagatgga gttttgctct      240

tgttgcccag gctgaagtgc catggtgcaa tctcggctca ctgcaacctc cgcatcctag      300

gttcaagcaa ttctcctgcc gcagcctcct gagtagctgg gattacaggc accccccacc      360

atgctcagct actttttgta tttagtggag atggggtttc accatgttgg ccaggctggt      420

ctcaaactcc ctacctcaga ccacggtgtg aacacatgaa cagaagacga aaatttcttc      480

tagcctcagt acttgctctc cagaattcaa gttttatata tccatcatgt cagaagtgct      540

tctctaggat aatcctggtc tccaaaaggt ctaattgtcc aaaatgtggc tctactggtg      600

aatctggaaa tgccaattac agatacaaac tttccttaaa agttgcagaa tcaaacaaat      660

tgtttgttat tactgtattt ggaagttgct tagatacatt ttttggtctt actgccactg      720

gtttgcacag gtacattcag gatcctaata aaattccaga aacactggac aatgatacaa      780

ctcagaatct attaactaaa gcagttgaaa cttgctttgt tggacaaagc tttatttttg      840

gagtgacgaa ttttgaaaac caacctggac aaggttcaga tgccagtaac ttcttacagc      900

aatgctctga ccacaaaaga aaagccaaag cactagtggc ttgccagatt gttctaccag      960

acccaggtat tgcaggcttt actgtcattg actacttcca tcaacttttg cagactttta     1020

atttcaggaa acttcagtgt gactctcagg cacctaacaa tcacttactt gctttagatc     1080

actcaaatag tgatctcagc agcatatata cttctgacag cacttctgat tttttcaagt     1140

cctgcagcaa ggatactttt tcaaaattct ggcagccatc acttgaattc acttgcattg     1200

tttcacaact aacagataat gatgattttt cagcttcaga acaaagtaag gcctttggta     1260

ctcttcagca gaacagaaag tccatctcca ttgcagaggc cactggttcc agtagctgcc     1320

atgatcccat tcaggattca tggagccttg tttcatatat ggataaaaag agtacagcag     1380

aaaagttggg taaagaactt ggcttacaag ctaaggagct gagtgcagtt cacagcagtc     1440

atcatgaaat tggagttaat gactctaatt tattctcttt ggaaatgcga gagccccttg     1500

agtcaagtaa tacaaaatcc ttccacagtg cagtggaaat taaaaatagg tcccagcatg     1560

agctaccatg ttttcagcat catggtatag ataccccaac tagccttcag aagagatctg     1620

catgttgtcc accttcgtta ctcagacttg aagagacagc cagcagttcc caggatggtg     1680

accctcaaat ttgggatgat ctgccattct ctgaaagcct gaacaagttt ctggcagttc     1740

ttgaaagtga gattgctgta acccaggcag atgtcagtag taggaaacat catgtagata     1800

atgacattga taaatttcat gcagaccaca gcaggttatc tgtgactccc cagagaacta     1860

ctggagccct gcatacacca cctatagctt taagatcatc acaagtaata gtcaaagcaa     1920

actgtagcaa agatgacttc cttttcaact gtaaaggaaa tctaagtcct agtgttgaaa     1980

aggagtcaca accagataac aaagtagagg ctgtctctgt aaatcataat ggaagagata     2040

tgtcagaata ttttttaccg aatccttacc tgtcagctct gtcttcatct tcaaaagatt     2100

tagaaacaat agttactctt aagaagacta tcagaatctc accacacagg gagagtgacc     2160

attctagtct aaataacaaa tatttgaatg gatgtggaga aatatcagtt tcagaaatga     2220

atgaaaagtt gacaactctg tgttatagga agtataatga tgtctctgat ctttgcaaat     2280

tagaaaataa acaatattgt aggtggtcca agaaccaaga tgacagtttt acaatttgca     2340

ggaaacttac atatccttta gaaactcttt gcaatagtcc aaatagaagt acaaatacat     2400

tgaaagaaat gccttgggga catatcaata acaacgtaac acagagctat tctattggtt     2460

atgaaggtag ctatgatgcc tctgctgatc tctttgatga tattgctaaa gaaatggaca     2520

ttgcaactga gattaccaaa aaatcacagg atattttgtt aaaatgggga acatctttgg     2580

cagaaagtca cccttcagag tctgattttt cactgagatc actttctgaa gacttcatcc     2640

agccttcaca aaaattatcc ttgcaaagcc tatctgactc taggcattca agaacatgct     2700

ctccaacacc tcattttcaa tcagattcag aatataattt tgaaaatagt caagactttg     2760

ttccatgttc acagtcaact ccaatttcag ggttccacca aacaagaatt catgggataa     2820

acagagcttt caaaaaacct gtattttatt cagatcttga tggtaactat gaaaaaataa     2880

ggattttccc tgaaaatgac aaacagcaag ccagcccaag ctgtccaaaa aatataaaaa     2940

cacctagcca gaaaatcaga agccctattg tatctggtgt ttcacaacca gacgttttca     3000

atcactaccc ttttgctgag tgccatgaaa ctgatagtga tgaatgggtc cctcctacca     3060

cacaaaaaat atttccttca gatatgcttg gattccaagg cataggtcta gggaaatgcc     3120

ttgctgccta tcatttccct gatcaacaag agttaccaag aaagaaactg aaacatatta     3180

gacaaggaac caataaaggt ttaattaaga agaaattaaa gaatatgctt gcagcagttg     3240

ttacgaaaaa gaaaactcat aaatataact gtaaaagttc aggctggatt tccaaatgtc     3300

cagacattca agtcttagca gcacctcagc tgcaccctat tcttggacct gattcttgtt     3360

cagaagtcaa atgttgcctt ccattttcag aaaaaggccc accttcagtg tgtgaaactc     3420

gaagtgcttg gtcacctgaa ttgttttcat aa                                   3452


<210> 3099
<211> 1579
<212> DNA
<213> Homo sapiens

<400> 3099
ggccgggagt tccccaagac cggaagtgtc ccgaggccgg gagcccgcgg gaccccggag       60

cgcgcggggc cggaagaggc gggcggccag tggaggtccg cagagtttgg gcgccaggcg      120

agacggcagg gcttaaagtt ccgggaatca aagatcaact cccactgagg acaaatggac      180

ctgtaattcc gggtgtgacg agagaacgag atttaccttc ctgaattaaa aaacaggtca      240

ttaagcttgg gccctgactc ttctttgtga gaaggtacag agatggaaac cttacaatcc      300

gagactaaaa cgagggtcct tccctcatgg ctgacagccc aggtggctac aaagaatgtg      360

gcaccaatga aggcccccaa gaggatgaga atggcagcag tgccagtggc agcagcaagg      420

tgcgacagct ctggtcagaa gactcctgcg aatctggcaa actccctgcg acaaggactg      480

tgtactgcat gaatgaggct gagatagttg atgttgctct gggaatcctg attgagagcc      540

gcaaacagga aaaggcctgc gagcagccgg ccctggcggg ggctgataac ccagagcact      600

cccctccctg ctccgtgtcg cctcacacaa gttctgggag cagcagtgag gaagaggaca      660

gtgggaaaca ggcactggct ccaggcctca gcccttccca gaggccgggg ggttccagct      720

ctgcctgtag caggagccct gaggaggagg aggaagagga tgtgctgaaa tacgtccggg      780

agatcttttt cagctagggc ataaactgtg cactgaactg tctgccgaga gcagctggag      840

gacagctgag cttccactgg tgctgctggg ccgcccgcct gtgggaatgg ggctctctgt      900

gctcctacct ttgtgccttc ttgggcctgg cagattcacc tcaggccaga agcccctgga      960

cactccgggc cttggggctg ccgttctgag tgtgcggaag gcaggactca aaatgagatc     1020

ccatttgact ccctctgtat gtactgtgcc ctctcctggc tcttgaggct ctggagtccc     1080

aattgtctgt gttagtcagt gaccaggttc cagggaaaat gatgtcatgt ggtggtccaa     1140

cttactggaa ccaaagagac agtactttgc aaagaaaagg atcactgcca ggtgcactgg     1200

aattgctaca gtttagtccg catgatctct cctgaaggag gaagcctgtt tcaaaaatag     1260

tttccatcat gagtctatca atgagctccc acctctccag ccagcctaga aagcaaacga     1320

gctgcccaca gttctctgcc ctgtctggga ggttgaggcc acagtgtata gactggtaag     1380

ccagacaggc ctcctcccgc aagctgctac cttgctttca cctgtacctt ggtccccggg     1440

cagctagcta taaagcaaga gggacaggag cccagaagag acactgagga caagagatca     1500

caccagagta catgtctctg cctctgtttt cagtgtggct ttggacagga atatatgaat     1560

aaatcactgc catacaggt                                                  1579


<210> 3100
<211> 1676
<212> DNA
<213> Homo sapiens

<400> 3100
ctccttccga gttaccgccg ccgtcgccgc cgctcctcct ctcccggtcc tgggtttcct       60

tggcgctgcg gccgccgctc cctctgcgac ctgtatgagg aggaggagga ggaggatgtg      120

aagatggcgg agctgcagat gctgctggaa gaggaaatcc cggggggccg ccgggccctc      180

ttcgacagct acacaaatct ggaacgggtg gccgattact gcgagaacaa ctacatacag      240

tcagcagata agcagagagc cctagaagaa accaaagcct acaccaccca atccttagca      300

agtgttgcct atctgataaa caccttggcc aacaatgtcc tgcagatgct ggatatccag      360

gcatcccagc tacgaaggat ggaatcttca atcaatcata tttcacaaac agttgatatt      420

cataaagaga aagttgcaag aagagaaatt ggtattttga ctaccaataa aaacacttca      480

aggacacata agattattgc tccagccaac cttgaacgac cagttcgtta tattagaaaa      540

cctattgact atacaattct agatgatatt ggacatggag taaaggtgag tacccagaac      600

atgaagatgg gtgggctgcc gcgtacaaca cctccaactc agaagccccc tagtccccct      660

atgtcaggga aagggacact tggcagcagt gggagtagtg gagggagcca cccaagtagt      720

cggagcagca gtcgagagaa cagtggaagt ggtagtgtgg gggttcctat tgctgttcct      780

actccatctc ctcccagtgt ctttccagcc cctgctggct ctgctggcac tcctcccctt      840

cctgctactt ctgcatctgc ccctgctcct cttgttcctg ctactgtccc ttcctccact      900

gccccagacg ctgctgctgg gggtgcccag acccttgctg atggcttcac ttctccaact      960

ccccctgttg tttcttccac tccccctaca ggtcatcctg tacagttcta cagcatgaat     1020

aggcctgcct ctcgccatac tcccccaaca atagggggct cgttgcccta tagacgccct     1080

ccttccatta cttcacaaac aagccttcag aatcagatga atggaggacc tttttatagc     1140

cagaatccag tttcagatac accacctcca ccgccacctg tggaagaacc agtctttgat     1200

gagtctcccc cacctcctcc tcctccagaa gattacgaag aggaggaagc tgctgtggtt     1260

gagtatagtg atccttatgc tgaagaggac ccaccgtggg ctccacgttc ttacttggaa     1320

aaggttgtgg caatttatga ctatacaaaa gacaaggaag atgagctgtc ctttcaggaa     1380

ggagccatta tttatgtcat caagaagaat gacgatggtt ggtatgaggg agttatgaat     1440

ggagtgactg ggctttttcc tgggaattac gttgagtcta tcatgcatta ttctgagtaa     1500

agctcagcag ggctgtgctt gcctcacagg aatagtcagg tcttcccaga ttatctgaag     1560

gccctgggga ttccactcca gtaaagtaga atgaaggata caaatgataa aaattacact     1620

tttttttttg gtttattccc cagtattaaa aacaaagcaa gctgagtctg aacaaa         1676


<210> 3101
<211> 8769
<212> DNA
<213> Homo sapiens

<400> 3101
taaagatata tccagaagaa atcactccac tcctaccagc catatcaggg gagaagattg       60

ctgaggacca aacctgcttt tttcttcaaa tactgttgaa gtatatggtt attcaggctg      120

cgagcttgga gtggaagaat aaggagaatc aagatactgg ttttaaattt ctttttacat      180

tgtttcgaaa gtattatctt cctcatttat ttccatcatt tactaagtta acaaacatct      240

acaaacctgt acttgacatc ccccatttga gaccaaagcc tgtgtacatt actaccactc      300

gagacaatga gaacatttac agtacaaaga ttccatatat ggcagctcgt gttgttttta      360

ttaagtggat tgtaaccttc tttttggaaa aaaagtatct aactgcaaca caaaacacta      420

aaaatggagt tgatgtattg cctaaaatca tccagactgt tggtggtggt gctgtgcagg      480

agagagcgcc tgagctggat ggtggtgggc ccacggagca ggacaaaagc cattctaaca      540

gcagcacctt gtcggaccga agactcagca actccagcct ctgtagcatt gaagaagagc      600

accgaatggt gtatgaaatg gtacagcgga ttctcttgtc aacacgaggt tatgtcaact      660

tcgtgaatga agtatttcac caggcatttt tgttgccttc ctgtgagata gctgtaacaa      720

gaaaagtagt tcaagtgtac agaaagtgga ttctccagga caaacctgtg ttcatggagg      780

agccagatag aaaagatgtt gcccaagaag atgctgaaaa attaggattt tccgagactg      840

atagcaagga ggcctcatct gaaagttctg gtcataaacg atcttccagt tggggacgca      900

catactcctt cacaagtgca atgagcagag ggtgtgtgac agaggaggaa aatacaaatg      960

tgaaagccgg cgtccaggct ttgttgcagg tatttttgac gaactctgca aacatctttt     1020

tgttggaacc atgtgctgaa gttcctgtgc tcttgaaaga acaagttgat gcttgtaaag     1080

ctgttttgat tatttttagg cgcatgataa tggagcttac aatgaataaa aagacatggg     1140

aacagatgtt gcaaatacta ctcaggataa cagaagctgt catgcagaag ccaaaggata     1200

aacaaataaa ggacttgttt gcccagagct tggcagggtt actatttagg acgctcatgg     1260

tagcttggat ccgagcaaac ctctgtgtgt acatttctcg agagctctgg gatgactttc     1320

ttggtgtgct gtcctccctc acggaatggg aggaacttat aaacgagtgg gccaacatta     1380

tggactcctt gacagcagtg cttgcaagaa ccgtttatgg agttgagatg acaaacctac     1440

ctctggataa attaagtgaa caaaaggaaa agaagcaacg aggcaaaggc tgtgttctag     1500

atcctcagaa aggaaccacc gtggggaggt ccttttctct cagctggcgg agccacccag     1560

atgtgaccga accgatgcga tttaggagtg ccaccacgtc tggagcaccg ggagtggaaa     1620

aggcaagaaa tattgttcgc caaaaagcaa ctgaagtgga ggagtgtcaa cagtcagaaa     1680

atgcacctgc agccggatct ggccatctca cagtgggaca gcagcagcag gtccttcgga     1740

gcagcagcac ctccgacatc cccgagccgc tgtgctcaga ttcttctcag ggtcaaaagg     1800

cagaaaacac acagaattcg agttcttcag agcctcagcc tattcaagag aataaaggac     1860

atgtgaagag agaacatgaa ggaataacaa tcttagttcg aagaagcagc agccctgctg     1920

aattggattt gaaagatgat ttgcagcaga cacaaggaaa atgtagggaa agacagaaga     1980

gtgaaagtac caacagtgac acaactctgg gctgtaccaa tgaggcagag ctgtccatgg     2040

gcccatggca gacctgtgag gaagacccag aactgaatac tcccacagat gttgtggctg     2100

atgctgatgc ccgtcattgg ttacaactga gtcccaccga tgcttcaaat ttaacagata     2160

gcagcgagtg cctcacagat gactgtagta taatcgccgg ggggagcctc actggttggc     2220

acccagactc tgctgctgtg ttatggcgaa gggtcttggg gatcctcgga gatgtgaata     2280

acatccagtc acccaagatc catgccagag ttttctgcta tctctatgaa ctctggtaca     2340

aactagcaaa gatacgggat aatctagcaa taagcctgga taaccagtct tctccatctc     2400

ctccagtttt gatcccacca ctcagaatgt ttgcatcatg gctgtttaag gcggcgacac     2460

tgccaaatga atataaggaa ggcaaactac aagcctacag gctgatctgt gccatgatga     2520

ccagacgcca ggacgttctg ccaaactcag atttcctggt gcatttttac cttgtgatgc     2580

acctgggatt aaccagcgag gatcaggata tcttaaatac gatcataagg cactgtccac     2640

cccgcttttt ctccctgggt tttcctggct tctcaatgct ggtgggggac ttcatcacgg     2700

ccgctgccag ggtccttagc acagacattt tgacggcgcc tcgttcagag gctgtcactg     2760

tcctcggctc tctggtctgc tttccaaata cctaccagga gattccttta ctgcagtcag     2820

tgccagaagt aaatgaggcc attacaggaa ctgaagatgt caagcattac ctcataaata     2880

ttttactgaa gaatgccaca gaagaaccaa atgaatatgc aagatgcatt gctgtttgct     2940

cccttggggt ctggatatgt gaagagcttg cacagtgtac aagccaccct caggtgaaag     3000

aggccatcaa tgtgatagga gtaactctga agtttcccaa caaaatcgtg gcccaggtag     3060

cttgcgatgt ccttcagttg ctggtttcct actgggagaa gcttcagatg tttgaaacct     3120

ctctgcctcg gaaaatggca gaaatcctcg tggccacagt tgcttttctt ttaccaagtg     3180

cagagtactc ctcagtggaa acagacaaga agtttattgt gtccttgcta ctctgcctct     3240

tggactggtg catggcattg cccgtgagtg tccttctcca ccccgtgtcc acagcagtcc     3300

tagaggagca gcattcggcc agagccccct tgctggatta tatctacagg gttttgcact     3360

gctgtgtgtg tggctcaagc acgtacaccc aacagagtca ctacatactg accctggctg     3420

acttgtcatc cacggattat gaccccttcc tgccactggc aaatgtgaag agctctgagc     3480

cagtccagta tcattcatca gcagaattgg gtaacctgct gactgttgaa gaggagaaga     3540

agagaagaag tttggagttg atccctttga ctgctcgaat ggtgatggcc cacctggtga     3600

accacctggg gcactacccc ctcagtgggg gccctgccat actgcacagc cttgtcagcg     3660

agaaccatga caatgcccat gtggaaggct ccgagctgtc ctttgaggtg ttcagaagtc     3720

caaacctgca gctgtttgta tttaatgata gcaccctcat ctcctacctt cagacaccca     3780

cagaaggacc ggtaggggga tcaccagtgg gctctctctc tgatgtgaga gtaattgtga     3840

gggatatctc agggaagtac tcttgggatg gtaaggtttt atatggacct ttggaaggct     3900

gcttagcacc caatggaaga aatccttcat ttctgatttc gagctggcat cgtgacacat     3960

ttggacctca gaaagactct tctcaagttg aggaggggga tgatgttctt gacaaattac     4020

ttgaaaacat tggccataca agtcctgaat gccttttacc gtcacagcta aatctaaatg     4080

aaccttccct aaccccatgt ggcatgaact atgaccaaga gaaggaaatc attgaggtca     4140

ttttgcgcca aaatgctcaa gaggatgagt atatccagag tcataacttc gattctgcaa     4200

tgaaagtcac cagccaaggg cagccctccc cagtggagcc ccgaggaccc ttttatttct     4260

gcaggttatt gcttgatgac ttgggaatga attcttggga cagaaggaag aattttcatc     4320

tattgaagaa aaattcaaaa ttattgagag agctgaaaaa tttggactcc cgccagtgcc     4380

gtgagacaca caaaatcgca gtgttttaca ttgctgaagg tcaagaagac aagtgttcaa     4440

tcctctctaa tgaaagagga agccaagcat atgaagactt tgttgctgga cttggatggg     4500

aggtggatct ctccacccac tgtgggttca tgggtggcct tcagcgcaat ggcagcaccg     4560

ggcagacggc cccttactat gctacctcaa ctgtggaagt gattttccat gtttccactc     4620

gaatgccgtc agactcagat gattccctca ccaaaaagct tcgtcacttg gggaatgacg     4680

aggtccatat cgtctggtct gaacactcca gagactaccg caggggtatt atcccaactg     4740

cctttggaga tgtttcaatc attatttacc caatgaagaa tcacatgttc ttcatcgcga     4800

taacgaagaa acctgaggtt ccattttttg ggcctctgtt tgatggagcc atagtgagtg     4860

ggaagctgct gccaagcctt gtatgtgcca cgtgcatcaa cgccagcagg gctgtgaagt     4920

gcctcatccc actctaccag agcttctatg aagagcgagc tctgtatctc gaagcaataa     4980

ttcagaacca ccgcgaagta atgacattcg aggatttcgc agcccaagtc ttttctccct     5040

ctcccagcta ctccctcagc ggaacggggg ccctggcctc cagtctgagt gctgacctcg     5100

aagagcccct gagtgaggag gagacagaac accctctcct gcctctgccc cgagccacta     5160

aacccagaat ctccaggaaa tttcgttgct gtactagtgc cctcagcagg tcttcccatt     5220

agtggacttc tgaagcccat ggtgaatccc actaccgtgt ctcagatggg actcaaacta     5280

ggctgtatca tcttgtcctg aaacctcaca aaccttggac ttccaaagaa gaaaagaaaa     5340

agtcaccaaa aaccagagat gaacccactg acacgtgggc actggtgtgg ctgctctggg     5400

cagatgacag caggaaaaga ttctgcgctt tcagggaggg ggcagagggc agcttgcttc     5460

tgcaccccaa gttgtttctt ctcatttatg aacccaagca tgattcacaa aggggctggc     5520

aaaacaattg tctaattgag gaatctgatc tgcattgatt ttgctagttc cttttatgtt     5580

aggatttatg gtttactcaa aaatttcatc atcatggaaa ttggctttcc ccggggtctt     5640

ttgcccagga gaagttttac ctcagttgtc cagtgttttc ccacatggta cctgacgccc     5700

gctaactaag cagaggctct cctcaccacg cagaggcgct tcaggtcatg acagtgatgc     5760

ccctatctta gaacactcag aagattccag aaatacaggg tcctgtcctt gcataagttc     5820

ctgcaggaca ggaagtgtcc caaggctcaa aacaacacag accacatcca cacaaaaggc     5880

gcatgccggc ttcaggcgct aggctgagac gggtaccccc cgaatggcct tgtgcctcca     5940

aaagcctcac gctgcaactt tgctgctcct gtctgttgcc cagagaggcc tcacacaggc     6000

ctcagaaatg tttcttgtca cacaaagctt ttggtagccg attccaagcg agggatttaa     6060

tccttacatt tttgcccatt tggctccaag gaaggcttat tagacctgtt tttttgttgt     6120

tgttgttttt ttttcttaaa aacaaaatga atgaatgaat gaaaagagaa gcaatggtga     6180

gccctctcct gctggggcgc cctgggtggg ccttgcccgt cctgcagcag agaaatcagt     6240

cagcagcgaa gagctgctgg cgcaggcccc aggctgtgtc ctggaccctt gacctgcctc     6300

agagctagag gtttgctcca ccccgcactt cacttgggaa gtaaatccaa gaagcttacc     6360

agagtccatc gccactgcgc aggctttgtt ctcacagcgg ccaggtacag agcaacgccc     6420

tgcagtggga agggacagca gcacgagaga cgcagcccct aactcagggc ttatgatggg     6480

tgggctggtc ctgggaaagg cgggccctgt gcgggaggcc tccccacctt cctgtgccct     6540

ctgccctctg cccttgcaca cacttgttac cttcaggctg cttggccacc caggcctgaa     6600

gaagccttct gaggctctca ccccatcaga acggccattt tcactgagga gccagttttt     6660

tccatttgcc atggagctgg tttggctgga acctggcctt tgtagggaaa acggggagac     6720

tcaggagcca gactcactct tgggacaaat gagaaagagc tgagccagtc gttcctgtcg     6780

gaagggcggg cctgctcatc ctggcgagaa tttgcttttc tgctttatag gggattgcag     6840

gccaggccca ctgacaggag caccttgaga accacctgaa cagaagagaa tgagggtgcc     6900

ccaaagtgga aggaagcttc tggcccctgg gccgttttgg gaagggccca ggatactcac     6960

gggggctgaa gggcaatgtg aagagtgact gcaagtcctg gcattttctg tggtgtcagc     7020

aaatgcccct ttattttaaa tgattccaga catctgggca gcatagcttg gccaccatca     7080

ctcaggcttg atcctgctgt tgagctgctc ctgtctcctg tttacctcac tcctgttggg     7140

aaggccatcg catgctccta ggctccagag tcccctgtag gtctctacca gcaggtcgcc     7200

tctgggagaa cgtttcatct tcaggctcta gaaactcctg ttgcggaatt gctggcttta     7260

gtagaaaaga tatgtcagga tttagaaatc gtattgaact ctcctggact tctgctccat     7320

gatttcattt tgctttcacg aaccagcgat ccctaccttg gggtgggaaa ttcaattgta     7380

ggcagcaaat aactcaaccc tcctgtaacc cctgaggatt ataacgaccc catgaccccc     7440

gatgacagcc agcagtttgg tgactagagt tttttgagcc tgccattctc agtagcagct     7500

ttggtctgga gatggaacgt ggagcaggga atctgacagc cacgtttctc gtgatcacgt     7560

ggactggagt tgtttttgtt atctggggtg gaaaattgca atgatcaagt ttctttttta     7620

tttttttttt acttagaaaa gcaaatattg tgtttttgta ataaatccct ttcagcaaaa     7680

ttgcggagga tcattcatcc actagggccc cacctgaggc acagcgctga ctcatcacgg     7740

tggtaccagt aggtcagcca tctggaaaca gaagtggccc taattgggcc aaaatgtggt     7800

aagactcgct ggcctcaggc agggccaggc cagttccctc acttctctgc acacctattc     7860

ccagattcca tccagagcaa agctgatgtt tatcgtctca ttgtacttag gctttcgtac     7920

tttaaaaaat tatgactttt taaaaataag ccttcagcag acagaagtga agaaatttag     7980

cctgggttgc ctcagcaaca aagtctgcgg ttcctaagag ccacatgttg gggaagtggg     8040

gtgacccaaa cttggtgaca taggttgatt gatcagaccc tcagccttac aagcaagagc     8100

tcatgcagat ccacagagcc atgcacatcc tgtcttcctg accttcctca ggtggcacca     8160

cctgcgcccc atggacctgc tgtatcggtg tcatgtggag gtctgatgaa tcctttaaaa     8220

cctaactgtg atgtcgtaaa tgtaactgtg ctacctttat atctactgaa gggcagcgtc     8280

tgcatccgag ggaaattcaa catgaaacaa ccatcgtttt agttgcactc agtctgtcca     8340

tatgacatac acatgaagtg aatgtttcct tatgttttca ggtctacaat gtttagtaca     8400

tgtaaataag gaaaaaattt gataaatatg gtaaattaag ttatagcgtg tcatttgatt     8460

cttattttgc tgtctcttgt tatttaattt tcctaatgct ccacatctag gttccttcct     8520

aggtggtggg aacaccttgc agacgtgtgt gcaccaggac acaccgcggc ccaggcagcc     8580

acaccgagaa agcacacatc tccactgatg gcagccaccc gactctccag ttaacctctt     8640

ttactcttta attctgattt actgtgatga tttaataaag tggaaacaca gcacttcagt     8700

gctatatgtt tctctcattc tcattatagt ttataagaaa ataaagttca ccctggcatc     8760

taataaaaa                                                             8769


<210> 3102
<211> 2234
<212> DNA
<213> Homo sapiens

<400> 3102
acacttcaaa tcctgagcgg ctgactgtca ggggtgcgtc aggcctgctt gctgggagaa       60

tggacgagct ggttgtggag cgggcgggtc ccgccacccg tgggctcagc actggactgc      120

tcccagaaca ttaaaggtct ggctgatgtt ccatgccaca tctggacatg aagacccatg      180

tctgcccttc tgtagaaggg ccaaagaaga aaggaggcat cacatgtttc tgctgtgggg      240

ggcccttccg agcagcagac aggagcaaga caaggagccc caaactgtct cacagtcctc      300

aaccacccag tctgggtgac ccggtcgagc atttatcaga gacgtccgct gattctttgg      360

aagccatgtc tgagggggat gctccaaccc ctttttccag aggcagccgg actcgtgcga      420

gccttcctgt ggtgaggtca accaaccaga cgaaagaaag atctctgggg gttctctatc      480

tccagtatgg agatgaaacc aagcagctca ggatgccgaa tgaaatcaca agtgcagaca      540

caatccgtgc tctcttcgta agtgcctttc cacagcagct caccatgaaa atgctggaat      600

cgcccagtgt cgccatttac atcaaagatg aaagcagaaa tgtctattat gaattaaatg      660

atgtaaggaa cattcaagac agatcactcc tcaaagtgta caacaaggat cctgcacatg      720

cgtttaatca cacaccaaaa actatgaatg gagacatgag gatgcagaga gaacttgttt      780

atgcaagagg agatggccct ggggcccctc gccccggatc tactgctcat ccaccccatg      840

cgattccaaa ttccccaccg tctactccag tgccccattc catgcccccc tccccgtcca      900

gaattcctta tgggggcacc cgctccatgg ttgttcctgg caatgccacc atccccaggg      960

acagaatctc cagcctgcca gtctccagac ccatctctcc aagcccaagc gccattttag     1020

aaagaagaga tgtcaagcct gatgaagaca tgagtggcaa aaacattgca atgtacagaa     1080

atgagggttt ctatgctgat ccttaccttt atcacgaggg acggatgagc atagcctcat     1140

cccatggtgg acacccactg gatgtccccg accacatcat tgcatatcac cgcaccgcca     1200

tccggtcagc gagtgcttat tgtaacccct caatgcaagc ggaaatgcat atggaacaat     1260

cactgtacag acagaaatca aggaaatatc cggatagcca tttgcctaca ctgggctcca     1320

aaacaccccc tgcctctcct cacagagtca gtgacctgag gatgatagac atgcacgctc     1380

actataatgc ccacggcccc cctcacacca tgcagccaga ccgggcctct ccgagccgcc     1440

aggcctttaa aaaggagcca ggcaccttgg tgtatataga aaagccacgg agcgctgcag     1500

gattatccag ccttgtagac ctcggccctc ctctaatgga gaagcaagtt tttgcctaca     1560

gcacggcgac aatacccaaa gacagagaga ccagcgagaa aatgatgaaa accacagcca     1620

acaggaacca cacagatagt gcaggaacgc cccatgtgtc tggtgggaag atgctcagtg     1680

ctctggagtc cacggtgcct cccagccagc ctccacctgt gggcacctca gccatccaca     1740

tgagcctgct tgagatgagg cggagcgtgg cggaactcag gctccagctc cagcagatgc     1800

ggcagctcca gctgcagaac caggagttgc tgagggcaat gatgaagaag gccgagctgg     1860

aaatcagtgg caaagtgatg gaaacaatga agagactgga ggatcccgtg cagcgacagc     1920

gcgtcctagt ggagcaagag agacaaaaat atcttcatga ggaagagaag atcgtcaaga     1980

agttgtgaaa gcagaaaaga aatgggagga aaaaaggcaa aatctggatc actataatgg     2040

gaaagagttt gagaagctcc tagaagaagc tcaggccaat atcatgaagt caataccaaa     2100

tctggagatg ccgccagcca caggcccact gccaagggga gatgccccag tggacaaggt     2160

ggaactttca gaagattctc caaattcgga acaggacttg gaaaagctgg ggggaaagtc     2220

gccccctcct cctc                                                       2234


<210> 3103
<211> 184
<212> DNA
<213> Homo sapiens

<400> 3103
cgagaacccg ctggtttatt gcgacgggca cggctgcagc gtcgcggtgc atcaagcttg       60

ctatggcatt gttcaagtac ccactggacc gtggttttgc aggaaatgtg aatctcagga      120

gagagcagcc agagtggttg ggcccatgtg gtttgtgccc tgtatattcc agaggtacaa      180

tttg                                                                   184


<210> 3104
<211> 2623
<212> DNA
<213> Homo sapiens

<400> 3104
cttctcctga gagtcggagc cacagccaga gccctgccca ggccgagccg gagctgcagc       60

ccgagcgcgg tggtgccctc agccccgtcc tcttgtcctc ctcagcctcg gtgccttgga      120

atttgtgtcg ctgagtcagc aagcctttca gatttgcccg gtttttgttg tttgtggttt      180

gtatcaagat gggaactcaa acaagtcatt cctcctaagg agctggtgtc ttcatccaga      240

agggacagtt tgtgccagct ctccagagag aaaagatctg ccggaggcgc tgggcaatga      300

ccccgggact ccaggccaga ggggtctgaa gctgtttggg aaagcagcgg gactccttgg      360

gaagatggcc atggccccaa gcccttccct ggtgcaggtg tacaccagcc ccgcggctgt      420

ggccgtgtgg gaatggcagg acgggctggg cacctggcac ccctacagtg ccaccgtctg      480

cagcttcatc gagcagcagt ttgtccagca gaagggccaa cgttttgggc ttgggagcct      540

ggcccacagc atccccttgg gccaggcaga cccctcgctg gccccttaca ttattgacct      600

ccccagctgg acccagttcc gccaggacac cggcaccatg cgggctgtgc ggagacacct      660

gttcccccag cactcagccc ctggccgagg tgtcgtctgg gagtggctga gcgacgatgg      720

ctcctggact gcctatgaag ccagcgtctg tgactatctg gagcagcagg tggccagggg      780

caaccagctc gtggacttgg cccccctggg gtacaactac actgtcaact acaccaccca      840

cacgcagacc aacaagactt ccagcttctg ccgcagcgtg cggcgccaag cagggccgcc      900

ttacccggtg accaccatca tcgctccgcc gggccacaca ggcgtcgcct gctcttgcca      960

ccagtgcctc agtggcagca gaactggccc cgtgtcaggc cgctaccgcc actccatgac     1020

caacctccct gcataccccg tcccccagca ccccccacac aggaccgctt ctgtgtttgg     1080

gacccaccag gcctttgcac cgtacaacaa accctcactc tccggggccc ggtctgcgcc     1140

caggctgaac accaccaacg cctggggcgc agctcctcct tccctgggga gccagcccct     1200

ctaccgctcc agcctctccc acctgggacc gcagcacctg cccccaggat cctccacctc     1260

cggtgcagtc agtgcctccc tccccagcgg tccctcaagc agcccaggga gcgtccctgc     1320

cactgtgccc atgcagatgc caaagcccag cagagtccag caggcgctcg caggcatgac     1380

gagtgttctg atgtcagcca ttggactccc tgtgtgtctt agccgcgcac cccagcccac     1440

cagccctccc gcctcccgtc tggcttccaa aagtcacggc tcagttaaga gattgaggaa     1500

aatgtccgtg aaaggagcga ccccgaagcc agagccagag ccagagcagg tcataaaaaa     1560

ctacacggaa gagctgaaag tgcccccaga tgaggactgc atcatctgca tggagaagct     1620

gtccacagcg tctggataca gcgatgtgac tgacagcaag gcaatcgggt ccctagctgt     1680

gggccacctc accaagtgca gccatgcctt ccacctgctg tgcctcctgg ccatgtactg     1740

caacggcaat aaggatggaa gtctgcagtg tccctcctgc aaaaccatct atggagagaa     1800

gacggggacc cagccccagg gaaagatgga ggtattacgg ttccagatgt cgctccccgg     1860

ccacgaggac tgcgggacca tcctcatagt ttacagcatt ccccatggta tccagggccc     1920

tgagcacccc aatcccggaa agccgttcac tgccagaggg tttccccgcc agtgctacct     1980

tccagacaac gcccagggcc gcaaggtcct agagctcctg aaggtggcct ggaagaggcg     2040

gctcatcttc acagtgggca cgtccagcac cacgggtgag acggacaccg tggtatggaa     2100

cgagatccac cacaagacag agatggaccg caacattacg ggccacggct atcccgaccc     2160

caactacctg cagaacgtgc tggctgagct ggctgcccag ggggtgaccg aggactgcct     2220

ggagcagcag tgacctcgca ccccagcacg cccgcctctg gtggccaccc cgctgcccca     2280

tggctggctg ggtggccagg caggaagtgc ccagcccgag aggctgggag gtttgttgag     2340

ggtgtggggt gtgccccacc tgaagccggg gctccccctg cctgcctctc tctcctcctc     2400

ccctctggga attgggcagc cctgggcagt tgtactcatg ggggcttagg atgcagctac     2460

ctcagtgcgc agggcccgtc tgtcctctgg gggctgcttc gggcccgcgg tgctcggggc     2520

ctggtgtggg gcgagtagag acttccccag cctggacggg cgtgggttct gggtcagctt     2580

cttttacctc aattttgttt gcaataaatg ctctatagcc aaa                       2623


<210> 3105
<211> 1879
<212> DNA
<213> Homo sapiens

<400> 3105
agatcctgtg ctgggcctcc caactggtgc atggacaggc tgaggaagca caggccgggc       60

agagccctgg ccaagagggg cgtcttgcgc ccacactcac ttggcaagtt tctgcagcac      120

ctgctcgcac tccagctgct tccgctcaag ctgctcagca tagggcactg tccatagagg      180

ggtcaccacg tcggccactc gtgttactgg tggctcactc tcaccctcct gtcgcctcct      240

cctggccatg gggtcggcct tgggccgggc caggcgcaca ctgagtgggc ggcctttcca      300

gagggcacca tgcaaaacgc gcagggcctt gtccctctct gcagcgctgc ggaatgtcac      360

aaaggcgcag ggtggttgcc caaagagttt ggttttgtgg ggctgcagac caaagcggcc      420

caggaagcgc cggacgtcgc tgaagctggc gtggcgagga cactcatgag gaccatgata      480

cttccactga gaatacagac gagtccaacc atgaccctca gtttgagcca atagtttctc      540

ttcctgagca agaaattaaa acactggaag aagatgaaga ggaacttttt aaaatgcggg      600

caaaactgtt ccgatttgcc tctgagaacg atctcccaga atggaaggag cgaggcactg      660

gtgacgtcaa gctcctgaag cacaaggaga aaggggccat ccgcctcctc atgcggaggg      720

acaagaccct gaagatctgt gccaaccact acaacgtgcc tctgaactca gagcaggccc      780

gcagcgaagc ttagagcaca cgggggtgtg gagtcagcca gacgggccct gatgggagga      840

cgcagcgccc aggctgggct cgggacgagg atcacgccga tgatggagct gaagcccaac      900

gcaggtagcg accgtgcctg ggtctggaac acccacgctg acttcgccga cgagtgcccc      960

aagccagagc tgctggccat ccgcttcctg aatgctgaga atgcacagaa attcaaaaca     1020

aagtttgaag aatgcaggaa agagatcgaa gagagagaaa agaaaggtga cgtggtgcca     1080

tgggttgggg ggcttctttg cagactcact ctgcatctga ctatacttcc aggcgggtgc     1140

tttttctgtc tgccagataa acattccagg gtgctgtggc cgcctcacgt atccagagtg     1200

atgcagctcc ctggggacac aggtgcttcc tggggagccc tgagcacttg tcagtgttgc     1260

tggcctcagt ccaattgggc aggcattgga gtccgggcac tgcctggagc tcaccagaag     1320

gtgctttatg atggtcctcg gtttgtctct cagagggctt ggtcacctct gccatgaggc     1380

tggactgcag ctgtggtggc aagtgaccag atgtcactga gcagcctgac catggtctag     1440

gcagtgcttg agtgcatcca cctggcttcc tttcgtcact gaatttcaag aagacagact     1500

ccaggaggcg gcttggccag gcaggagtct gtcccgaggg cgggcaagcc gctgtgggtg     1560

ggtgacggca cttgggacca gcctggcgag ggccatgtgc ttgaatgcac cgtgcttctg     1620

ttttctcact gtgctgcttg tgtttttagc aggatcaggc aaaaatgatc atgccgaaaa     1680

agtggcggaa aagctagaag ctctctcggt gaaggaggag accaaggagg atgctgagga     1740

gaagcaataa atcgtcttat tttattttct tttcctctct ttcctttcct ttttttaaaa     1800

aattttaccc tgcccctctt tttcggtttg tttttattct ttcattttta caagggacgt     1860

tatataaaga actgaactc                                                  1879


<210> 3106
<211> 488
<212> DNA
<213> Homo sapiens

<400> 3106
atgaagagac cgggcgcagc gcgacccggg aagctccgcc gaggtggttt cctagaaaca       60

tgattgttta ttggcattga tctcacagtc tggtgaggac ttctttactg ataatgtcaa      120

gttcaggtta tcctcccaac caaggagcat tcagcacaga acaaagtcgt tatcctcctc      180

actctgtcca gtatacattt cccaacaccc gccaccagca ggagttcgca gtccctgatt      240

atcgttcctc tcatcttgaa gtgagtcagg catcacagct tttgcagcaa cagcagcagc      300

aacagcttcg aaggcgacct tccttgcttt cagaatttca cccaggttct gacaggcctc      360

aagaaaggag aactagttat gaaccgtttc atccaggccc atccccagtg gatcatgatt      420

cactggaatc gaagcgacca cgtctggaac aggtttctga ttctcatttt cagcgtgtca      480

gtgctgcg                                                               488


<210> 3107
<211> 623
<212> DNA
<213> Homo sapiens

<400> 3107
ggagttgccg ggggtcggtc tttccgcagg agctactctg acctacgaca ctctccggtt       60

tgctgagttt gaagattttc ctgagacctc agagcccgtt tggatactgg gtagaaaata      120

cagcattttc acagaaaagg acgagatctt gtctgatgtg gcatctagac tttggtttac      180

atacaggaaa aactttccag ccattggagg ttgtcgggac atttcactct ccagtaaatg      240

tggcccttgg cgttactgag tcctaagagg ggggacaggc cccacctcgg acacaggctg      300

gggctgcatg ctgcggtgtg gacagatgat ctttgcccaa gccctggtgt gccggcacct      360

aggccgagat tggaggtgga cacaaaggaa gaggcagcca gacagctact tcagcgtcct      420

caacgcattc atcgacagga aggacagtta ctactccatt caccagatag cgcaaatggg      480

agttggcgaa ggcaagtcca taggccagtg gtacgggccc aacactgtcg cccaggtcct      540

gaagaagctt gctgtcttcg atacgtggag ctccttggcg gtccacattg caatggacaa      600

cactgttgtg atggaggaaa tca                                              623


<210> 3108
<211> 2097
<212> DNA
<213> Homo sapiens

<400> 3108
gccttgggga catttagggc agagcctcga gtgacaggtc ctgggacagt gggagccaag       60

ggcaagtgct agagttgcag tgaatttaga gcaaagcctc agctaagtga cacatcccag      120

ggcagtaggg gatctatcta ggttcgtgct gggcctcagg taagtgacag gccttaggac      180

aatgggggct gtggcatgcg tcaggttacc tgccttgata tgggatcgtg acaggcccct      240

ccctatgtgc aggagacaag cagcccaaga aacaggagaa aaacccagtg ttggtgtccc      300

cagagtttgt ggatgaagct ctgtgtgcgt gcgaggagta ccttagcaac ttggcccaca      360

tggacatcga caaggacctg gaggccccgc tgtacctcac ccccgagggc tggtccctct      420

tcctccagcg ctactaccaa gtggtccacg aaggggcaga actcaggcac ctcgacactc      480

aggtccagcg ctgtgaggac atcctgcagc agctgcaggc cgtggtaccc cagatagaca      540

tggaagggga tcgcaacatc tggatcgtga agccaggagc caagtcccgc ggacgaggca      600

tcatgtgcat ggaccacctg gaggagatgc tgaagctggt gaacggcaac cccgtggtga      660

tgaaggacgg caagtgggtg gtgcagaagt atattgagcg gcccctcctc atctttggca      720

ccaagtttga cctcagacag tggttcctgg taactgactg gaacccactt accgtgtggt      780

tctaccgcga cagctatatc cgcttttcca cgcagccctt ctccctgaag aacctggaca      840

actcagtgca cctgtgcaac aactccatcc agaagcacct ggagaactca tgccatcggc      900

atccactgct tccgccagac aacatgtggt ctagccagag gttccaggcc cacctgcagg      960

agatgggtgc cccaaatgct tggtccacca tcatcgtgcc tggcatgaag gatgctgtga     1020

tccacgcact tcagacctcc caggacaccg tgcagtgtcg gaaggccagc tttgagctct     1080

atggcgctga cttcgtgttc ggggaggact tccagccctg gctgattgag atcaacgcca     1140

gccccacgat ggcaccctcc acagcagtca ctgcccggct ctgtgctggc gtgcaagctg     1200

acaccctgcg cgtggtcatt gaccggatgc tggaccgcaa ctgtgacaca ggagcctttg     1260

agctcatcta taagcagcct gctgtggagg tgcctcaata tgtgggcatc cggctcctgg     1320

tagagggctt caccatcaag aagcccatgg cgatgtgtca tcggcggatg ggggtccgcc     1380

cagcagtccc tctgctgacc cagcgaggct ctggggaagc ccgtcaccac ttccccagcc     1440

tccacaccaa ggcccagctg ccttctcccc atgtactccg acaccagggc caggtcctca     1500

gacgacagca cagcaagctg gtgggcacta aggccctgtc gaccacaggc aaggccttga     1560

ggactctacc cacggctaag gtcttcattt ccctcccacc gaaccttgat ttcaaggtgg     1620

cacccagcat cctgaagcca agaaaggtgg gcctcgacct gtgactcaca cccagtggac     1680

agtgctgagc acggggtcag ggctggaggg cacaggcaga gggcagctcc caggctggct     1740

ggcaccccaa gggaagagct ggtctccctc agaagcccct tcctccacag acttctgatc     1800

atctccctct tctcccctcc tttcacaccg aggctcctgc tctcctgtgc ctccgaggcc     1860

cccagctgga agtgccttgt tgcctctgcc ctttgaagtc ggaacaattc ctagcacctg     1920

tcggaaggtc aaggccaaag gcaaattcaa ggccagactg tgacaaaccc agggctgagg     1980

cctgccccat gaagaggctg agccccctga aacccctgcc ccttgttggt acattccaga     2040

ggcgcagggg cctgggggat atgaagctag ggaagcccct gcttcgattc cccactg        2097


<210> 3109
<211> 965
<212> DNA
<213> Homo sapiens

<400> 3109
agccggggcc tggtgcagcc tccgcggccg ctgtcaggga agcgcaggcg gccaatggaa       60

cccgggagcg gtcgctgctg ctgaggcggc agtgtcggca gtccaaccgc gactgcccgc      120

accccctccg cgggggtccc ccagaggatc aactaaacct tgaactaaga agaaaaatgt      180

gttgtgagca gggggagcct cagctgcctc aggccgttca ggacagaagg gtgtttctga      240

aggccggagc aagttttgaa gaagtcccta tcagattaca cttggttgac tactccggag      300

cagccactaa gagggatgaa caggcctgcg tggaaattga atgagattcc tgttcgactg      360

gctcctgaga gagaattcat caagtccctg atggcgatcg gcaagcggct ggccacgctc      420

cccaccaaag agcagaaaac acagaggctg atctcagagc tctccctgct caaccataag      480

ctccctgccc gagtctggct gcccactgct ggctttgacc accacgtggt ccgtgtaccc      540

cacacacagg ctgttgtcct caactccaag gacaaggctc cctacctgat ttatgtggaa      600

gtccttgaat gtgaaaactt tgacaccacc agtgtccctg cccggatccc cgagaaccga      660

attcggagta cgaggtccgt agaaaacttg cccgaatgtg gtattaccca tgagcagcga      720

gctggcagct tcagcactgt gcccaactat gacaacgatg atgaggcctg gtcggtggat      780

gacataggcg agctgcaagt ggagctcccc gaagtgcata ccaacagctg tgacaacatc      840

tcccagttct ctgtggacag catcaccagc caggagagca aggagcctgt gttcattgca      900

gcaggggaca tccgccggcg cctttcggaa cagctggctc ataccccgac agccttcaaa      960

cgaga                                                                  965


<210> 3110
<211> 1667
<212> DNA
<213> Homo sapiens

<400> 3110
atggccaagt ggggccaggg gaacccccac tggatcgtgg aggagcggga ggacgggacc       60

aacgtgaaca actggcgctg gcggacagag cgggatgcca ccagcttgtc caaagggaag      120

ttccaggagc tcctggtggg catcgttgtg gagaatgacg ctggccgcgg cgagatcaac      180

gagttgaagc aggtggaagg ggaggcttcg tgcagcagcc gcaaaggaaa gctgattttc      240

ttctatgagt ggaacatcaa actgggctgg aaaggcatcg ttaaagaatc tggagtgaag      300

cacaagggat tgattgaaat acccaatctt tctgaggaaa atgaagtaga tgacactgag      360

gtatcgttga gtaaaaagaa aggagatggg gttatactga aggatcttat gaaaactgca      420

ggcactgcca aggtcaggga ggcccttgga gattacctga aggcacttaa gacggaattt      480

acaacgggaa tgattttacc aacgaaagct atggcaaccc aggaattgac tgtcaaaaga      540

aaactgagtg ggaataccct gcaggttcag gcctcatctc cagtggcact gggtgtaagg      600

attcccactg tggctcttca catgatggaa ctgtttgaca caactgtaga gcagctgtat      660

agcatcttca ctgtaaagga gttaacaaat aagaagatca tcatgaaatg gagatgtggg      720

aactggccag aagaacacta tgccatggtt gcactgaatt ttgtgcctac tctagggcaa      780

acagaattac aattgaagga gttcctatct atctgtaaag aagagaacat gaaattctgt      840

tggcagaagc agcattttga agaaataaaa ggttcactgc agctgacccc cctaaatggt      900

tgaattaaaa tttattataa ggcattactt tttgtaagcg gaaaaagtgt cacatttacc      960

tcttccctat cttttgttta aaaggactgt ctttatttta tattggatga aatctatgaa     1020

catatataca atgtaaagca ttgtttgact ctttattata actagacact gcattgattt     1080

aaaagtagca aacaacctga aattaagtat taacctgacc ttccatcgat attcctctgg     1140

aaataggtaa gtcctgagtg cagatagttg atgtttccca agctgaagct tgtcctatag     1200

caagcttgct tgcagctgta cttttagttc aagatgacaa aaaataaatg gcatgttgac     1260

actattcctt tattttactt tagggttttt aaggtgtgta gatcttaggt cgtaaaacag     1320

tggtatattg cattcaaaag catgttgagg tgagggcaaa ttggctgtgt tttgctccac     1380

atctccctgc acatctccct gctgtggttt tgcacttcgg tgtggagagg attgagaagt     1440

ctgtggggac acattagttc tgtggactgc tggtaacact tccagtgaaa cagcatataa     1500

tggataaatg tttcccccct ctttcacggt tttctcacta ctttcacctg agaagactga     1560

agcaacgtat gtaaacaaat gaaaagtcat cacaatcagt ttaattaagt gcacagaata     1620

gcaatcaatc aatcagtcat gtcaataaaa ataaaacaat tattttt                   1667


<210> 3111
<211> 1591
<212> DNA
<213> Homo sapiens

<400> 3111
agcatttccg gcagccatcc ccgcggtgct gacatcccgg ttgttcttct gtgccggggg       60

tcttcctgct gtcatgaagg acgtaccggg cttcctacag cagagccaga actccgggcc      120

cgggcagccc gctgtgtggc accgtctgga ggagctctac acgaagaact ttatgaaaac      180

tttatcagtg aatttgaaca caggtaaaag cctctcatcc gtttttcact ttgaaaatga      240

gtgcattgat gctcggcggt gctcaaaggc tggtggcttt tatttcaggg tgaacccttt      300

gtccctcgtg gaaatcattc ttcatgtagt tagacagatg actgatccta atgtggctct      360

tacttttctg gaaaagactc gtgagaaggt gaaaagtagt gatgaggcag tgatcctgtg      420

taaaacagca attggagctc taaaattaaa catcggggac ctacaggtta caaaggaaac      480

aattgaagat gttgaagaaa tgctcaacaa ccttcctggt gtgacatcgg ttcacagtcg      540

tttctatgat ctctccagta aatactatca aacaatcgga aaccacgcgt cctactacaa      600

agatgctctg cggtttttgg gctgtgttga catcaaggat ctaccagtgt ctgagcagca      660

ggagagagcc ttcacgctgg ggctagcagg acttctcggc gagggagttt ttaactttgg      720

agaactcctc atgcaccctg tgctggagtc cctgaggaat actgaccggc agtggctgat      780

tgacaccctc tatgccttca acagtggcaa cgtagagcgg ttccagactc tgaagactgc      840

ctggggccag cagcctgatt tagcagctaa tgaagcccag cttctgagga aaattcagtt      900

gttgtgcctc atggagatga ctttcacacg acctgccaat cacagacaac tcacttttga      960

agaaattgcc aaaagtgcta aaatcacagt gaatgaggtg gagcttctgg tgatgaaggc     1020

cctttcggtg gggctggtga aaggcagtat agacgaggtg gacaaacgag tccacatgac     1080

ctgggtgcag ccccgagtgt tggatttgca acagatcaag ggaatgaagg accgcctgga     1140

gttctggtgc acggatgtga agagcatgga gatgctggtg gagcaccagg cccatgacat     1200

cctcacctag ggccccctgg ttccccgtcg tgtctccttt gactcacctg agagaggcgt     1260

ttgcagccaa tgaagctggc tgctcagacg gtcgacattg aatttgggtg ggggttggga     1320

tcctgtctga agtacagact gttcttgctc taaaaacagg actgtccctg atgggagcca     1380

ggccacaggg aggaggcttc tttgtgggtc tctcctgcag agggtggggg tctcagggtc     1440

ttaggtgata cgggagagaa agaacgtgcc aggcaggagg ccccctgaag tctgtgtact     1500

ccgaggtgga tctccatccc catccacctg tacggacatc ttttccgttg cggtttgaga     1560

atgttcctat aataaacccc tctgctttgt t                                    1591


<210> 3112
<211> 873
<212> DNA
<213> Homo sapiens

<400> 3112
aggagacacc gccgcagttg ccggtacatc ggggatttct ggctctttcc tcttcgcctt       60

aaattcgggt gtcttttatg aataatcaaa agcagcaaaa gccaacgcta tcaggccagc      120

gttttaaaac tagaaaaaga gatgaaaaag agaggtttga ccctactcag tttcaagact      180

gtattattca aggcttaact gaaaccggta ctgatttgga agcagtagct aagtttcttg      240

atgcttctgg agcaaaactt gattaccgtc gatatgcaga aacactcttt gacattctgg      300

tggctggtgg aatgctggcc ccaggttttt aacaagttaa tcaggcgcta caaatacctg      360

gagaaaggtt ttgaagatga agtaaaaaag ctgctgctgt tcttgaaggg tttttcagag      420

tcggagagga acaagctagc tatgttgact ggtgttcttc tggctaatgg aacacttaat      480

gcatccattc ttaatagcct ttataatgaa aatttggtta aagaaggagt ttcagcagct      540

tttgctgtga agctctttaa atcatggata aatgaaaaag atatcaatgc agtagctgca      600

agtcttcgga aagtcagcat ggataacaga ctgatggaac tctttcctgc caataagcaa      660

agtgttgaac acttcacaaa atattttact gaggcaggct tgaaagagct ttcagaatat      720

gttcggaatc agcaaaccat cggagctcgt aaggagctcc agaaagaact tcaagaacag      780

atgtcccgtg gtgatccatt taaggatata attttatatg tcaaggagga gatgaaaaaa      840

acaacatccc agagccagtt gtcatcggaa tag                                   873


<210> 3113
<211> 3546
<212> DNA
<213> Homo sapiens

<400> 3113
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact     1560

catatcaacc caagtaccat gtggacttga tccctggctg aatcacctgg atgacttgga     1620

atagaaatga ctgctttaga agatgggatg gggccgggtg gtaagggata gaagagagga     1680

ctctcaatct actgatcaag tcctttcccc aatgcccagt ggatggccag ggtacctggg     1740

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1800

tagaaagggc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1860

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1920

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1980

agtgtggtgg ccactggtga cttgaaaata tagagaaaaa aaaaacctgc tctatatctg     2040

aaagagctct tgggaagaca gagaaacata aagaggaaat tacagcacag tgtggtgggt     2100

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     2160

ggaaggagag ggtgagtggg ggatggcttt ctgaaaaggg tggtctaaag gatgcctatg     2220

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     2280

ggatgacctg tgactctgga gcactgggtt gtctccattg tcattatggg cagatgtgtg     2340

ccatccccag ccgacgccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     2400

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     2460

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     2520

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2580

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaacttta     2640

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2700

ggaatagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2760

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gtgtaaacta     2820

caatgctctg tcatctccct actgggtctc ctgggaggag gggagccatc cagggtgcaa     2880

actcaaaggc agagggcaca gcgtgcttag gcccaagctt agaattcaat tgagaagttc     2940

tgttgttcat ccttacctca gcaggtagaa aagaggtgga gatcagaagc cagggattag     3000

agattgaatt gctttccctg ggagtgtgca gtatctcatt aaaatgttgt atattcaaaa     3060

aaatacagac acacacaagt gcctatataa tgataaaaca tatccaaagc acccaaacct     3120

gtgattccag aaaagtagat cctatttttg tttattttta ttggctttag ctgtgtcttt     3180

tgaaaggact attatcctct aaaatgtatg tgtatgaaga tcctggcttg cagctcggga     3240

gctttacaca ccttgtgtca ctttatcttg gtaacgagcc aagatcatgc aaccagttca     3300

tccatgtctg acccaagagc tcttaactgc tatgctgcac tgcctcattc agagatagat     3360

gcctgcatgg gtcctggcga ttattttaat gctggctaca cccccacagg tgacttggat     3420

tcagaaatac aatttatatt tcttcttttt aaattgtttt attttatttt tcttttaata     3480

gttatatgtc agtgagaaca atttatatgt cttacactga gaaataaaac tgctcataag     3540

tgaaaa                                                                3546


<210> 3114
<211> 832
<212> DNA
<213> Homo sapiens

<400> 3114
ccgcaatcat ggtgagtgtt ggtactgagg aggcctagca gggtgaaggc cacggtcgcg       60

gccttcacgg gttcctcggc cgtcctgagt cccaaatccc aagctggagc cgttcagctc      120

ccctccaccg cttagagatt tggggggctc tggccccgtc cttgcggacc attccgaggg      180

gagtccagag gtgaggccga ggaacctccc tgactttgcg gggcgcgccg ctcctgcgtc      240

tcctgccagt ctcccttcct tcttttcggt caacaattga aaacaaaacg aggaacagca      300

gaggagctac tgtataccga gccctcagca ttgttcgtaa tctccgcctg ctaacagcct      360

tgtgaagaag gtgctattct tctcaacact ttacagatga ggacacttga ggttcggaga      420

cgtggagcct cttgcacagc tgcttaagtg gtagtagagc cgagatttga accctcctaa      480

ccattccttt ctgccgccta ctgcagctcc cagcagagat gattgaactg ttgctcgggg      540

tagggccccc agggcttgtg ctggaaaaga tgaaatgggg aaaatggtgt cagtaattaa      600

cactgtggat acctcccatg aggacatgat tcacgacgcc cagatggact actatggcac      660

ccgcctggca acctgctcat cagacaggtc cgtcaaaatc tttgatgtgc gcaatggagg      720

gcagatcctt atcgccgacc tcaggggtca tgagggtcct gtgtggcaag tggcctgggc      780

tcaccccatg tacggcaaca tcctggcatc gtgctcctat gaccggaaag tc              832


<210> 3115
<211> 941
<212> DNA
<213> Homo sapiens

<400> 3115
gagtccctgc ttcgcagagc accggacttg gagtcagaga gacctggctg cgaatcccgg       60

ctccgccact ttctagcgct gtgaccttgg ttttcaggtg gcgaaactga ctggtctggt      120

tagagcgcgt ccaagccaag ccgcagtgct gtttggattt ttaaatttct ccttctgagt      180

gagaaaatag caatcgagat ggaaccatcc gcacaacagc tccagctggc agcatcactt      240

cccgccaatt tatccaactt ctgccaaggc tctgaaatgc caacaacgtc gaggcctgca      300

cttgatgtca agggtggcac ctcacctgcg aaggaggatg ccaaccaaga gatgagctcc      360

gtggcctact ccaaccttgc ggtgaaagat cgcaaagcag tggccattct gcactaccct      420

ggggtagcct caaatggaac caaggccagt ggggctccca ctagttcctc gggatctcca      480

ataggctctc ctacaaccac ccctcccact aaacccccat ccttcaacct gcaccccgcc      540

cctcacttgc tggctagtat gcacctgcag aaacttaata gccagtatca ggggatggct      600

gctgccactc caggccaacc cggggaggca ggacccctgc aaaactggga ctttggggcc      660

caggcgggag gggcagaatc actctctcct tctgctggtg cccagagccc tgctatcatc      720

gattcggacc cagtggatga ggaagtgctg atgtcgctgg tggtggaact ggggttggac      780

cgagccaatg agcttccgga gctgtggctg gggcagaatg agtttgactt cactgcggac      840

tttccatcta gctgctaatg ccaagtgtcc ctaaagatgg aggaataaag ccaccaattc      900

tgttgtaaat aaaaataaag ttacttacaa agagacgggc c                          941


<210> 3116
<211> 761
<212> DNA
<213> Homo sapiens

<400> 3116
attcacccag cgcattccgc cgcccgcagg cttgcgggga aacttcctta ttattgtgac       60

gccgaaaacg gagaaacccc gggtccggcg agaggggctg tgacagtcgg agtcccaagc      120

tgcggttcgg ctgctgccga gaactgcaag gtgtggaata tttctggctt ctagtccaat      180

gccaagtgtg tgacctgtga gttaattctg cattttagtt ttggccctac atttatttaa      240

agcctgaatt tggggagtat ctgcaaagca ctgaaggttt tggacattgt cttttcctgc      300

tgttgaaaga gaccctcttc atatatacaa cattcaggct acatgattcc ctgaaagata      360

agaacaatgt tatgttgggg atattggtct ctgggccaac ctggtatcag caccaacctg      420

cagggaattg tggctgagcc ccaggtgtgt gggttcatat ctgacagaag tgtcaaggaa      480

gtggcctgtg ggggaaacca ctctgtgttc ctgctggaag atggggaagt ttacacatgt      540

ggtttgaaca ccaaggggca actgggccat gagagggaag gaaacaagcc agaacaaatt      600

ggagctctgg cagatcagca tatcattcat gtggcatgtg gcgagtccca cagtctggcc      660

ctcagtgacc gaggccagct gttttcttgg ggtgcaggga gtgatggtca gctaggactc      720

atgactactg aggattctgt ggcagtgccc aggttaatac a                          761


<210> 3117
<211> 4288
<212> DNA
<213> Homo sapiens

<400> 3117
atggaagggg cgctgactgc ccgggacaag gtcggggttc aggattttgt gctattggac       60

gcgtacacca gcgaatctgc ctttgtcgac aacctccgca agcgtttcag cgagaacctc      120

atatacacat atattggcac cctccttgtg tctgtgaatc cataccagga gctcggaatc      180

tacactgtga gccagatgga actttatcaa ggggtcaatt tctttgaact gccaccacat      240

gtctacgcta tagccgacaa cgcttaccga atgatgtgtg ctgaactaaa taaccatttc      300

atcctcattt ctggagagag tggggcaggg aaaacagagg cctccaagaa aattctcgag      360

tattttgcag tgacctgccc aatgacccag tcactacaaa tagcccgtga cagactgctg      420

ttctccaacc cagtgctgga ggcttttgga aatgccagaa cgctccggaa tgacaactcc      480

agcagatttg ggaaatacat ggatatacaa tttgattttc agggcattcc cgtaggtggg      540

catatcatca gttacttgat agagaagtcc cgagttgtct accaaaacga aggcgagcgg      600

aatttccaca tcttctacca gctgctggca ggtggcgaag aggagcgcct gtcttacctg      660

ggactcgagc gagaccccca gctgtataaa tacctctcac agggtcattg tgccaaagag      720

tcatccatta gtgacaagaa tgactggaaa actgtttcca acgccttttc tgtcattgat      780

tttactgaag ctgacctcga gaatctcttt ggaattattg ccagtgtctt acacctgggg      840

aacattggtt ttgaagaaga cgaccaaggc tgtgccacta tcccagacac ccatgagatc      900

aagtggatag ccaagctcct gggggtccac ccatcagtcc ttctggaagc tctcacccac      960

agaaaaattg aagccaaaac tgaggaggtg atctgcccgt tgacactaga actctctgtc     1020

tacgctagag atgcaatggc aaaggctgtt tatggacgaa cgtttacttg gctggtcaac     1080

aaaatcaatt cctccttagt taacaaggtt ggtcaacgca ttttggatcc cttgctcttg     1140

ctcacgtgga aaactgtaat tggattactg gacatctatg ggtttgaagt ctttgacaag     1200

aatggttttg aacagttctg tataaattac tgcaatgaga aactccagca actgttaatt     1260

gagaggactc taaaagcaga acaggcagaa tatgaaatgg aaggcataga gtgggagcca     1320

attaaatatt tcaacaacaa gatcatctgt gatttggtag aagagagaca taaaggaatc     1380

atatctattc tggatgaaga atgcattcgg cctggtcctg ctacagactt gagtttcctg     1440

gagaaattgg aagagaaagt gggcaaacat gcacacttcg aaacccgtaa gctggctggt     1500

ccaaagggcc gaaagaggat tggctggatg gagttccgac tcctccacta tgcaggagag     1560

gtcacatact gcaccaaggg attcttggaa aaaaacaatg atcttcttta cagacatctg     1620

aaagaagtgc tgtgcaagtc caagaacatt atcctgaggg aatgcttcct gctggccgag     1680

ttagaaaacc ggaggaggcc cccaacagtg gggactcagt ttaaaaacag tctgagcagc     1740

cttctagaaa ccctcatctc taaggagccc tcctacatcc gttgcatcaa gcccaacgac     1800

aggaaagaac ccagcaaatt tgatgacttc ctcataaggc atcagatcaa atacctgggg     1860

ctgatggagc acctgcgggt gagacgggct ggttttgcat accgaaggaa atacgagcat     1920

ttcttgcaaa ggtacaagtc cttatgccca gacacctggc cgcactggca cgggcctcca     1980

gcagagggcg tggaacggct gatcaagtac atcggctaca aacccgagga atacaagtta     2040

ggcaaaacca aaatattcat tcgtttcccc agaactctgt ttgctaccga agatgccttt     2100

gaatttagta aacatcaact agttgcaaga atccaagcca cttacaaacg ctgcctagga     2160

aggagagaat acgtgaaaaa aagacaagca gccatcaaac tggaagccca ctggcgtggg     2220

gccctggctc ggaaggcaat ccaaaggaga aagtgggccg tgcggattat cagaaagttc     2280

attaaaggat tcatcagtcg caacaaaccc ctctgtcctg acaacgagga atttatcgtg     2340

tttgtgcgga agaattacat cttgaatctc cggtatcacc ttccaaagac tgtcctggac     2400

aagagctggc tgaggcctcc tggcatcttg gaaaatgcat cagatctgct caggaaaatg     2460

tgcgtgagga acctggtgca gaagtactgc cgcgggatca cagctgagcg gaaagcaatg     2520

atgcagcaaa aggtagttac aagtgaaatc ttcaggggaa ggaaagacgg ctacacagaa     2580

agtttaaatc aaccctttgt caacagtcgg atagatgaag gagacattaa tccgaaagtg     2640

cttcagctaa ttagccatga gaaaatccag tatggtgtcc cggtcattaa atatgacaga     2700

aaaggcttca aagcacggca gcggcaactc attcttactc agaaagcagc ttacgtggtg     2760

gaacttgcca aaatcaagca gaaaatagag tactcagctc tcaaaggtgt ctccactagc     2820

aatctgagtg atggaatctt agtcattcat gtttcaccag aggacagcaa gcaaaagggg     2880

gatgccgttt tgcagtgtgg acacgtgttt gaagcagtta ctaaactcgt catgctggtt     2940

aagaaggaga acattgtcaa tgttgttcaa ggaagtttac agttttttat tagtccggga     3000

aaagaaggca caatagtttt cgacactgga ctggaagaac aagtctataa aaataaaaat     3060

ggacaattaa cagtggtgtc agtccggagg aagtcctgat agaggatgac gtctgacctc     3120

taccatcgcc atttttgctc caactgagga aactacaggg gaagtgggga ttggatccag     3180

ttagctacct cttcaaggta ccaggcccgc agcactaaca gatcacatct gaagaaactg     3240

aggggcgtta ggccaaagcc taatcccagc tcctcagctg ccccatggca ccttatttaa     3300

aatgtcacct tctggaagca gaccccaggt cacccgaagg cgcaattcta aacaccctcg     3360

acaggatcta tgttcagtgc gcagtccaac gtgtcattag agggtgggca agattctcta     3420

cctctgtcaa gctgccctga gacatgatga aatactgtgt acagcaagtt ctcaaataac     3480

atttcgttat atgttgataa gacatctgat tcctgggcag ggccactgtc tgggtggagt     3540

ctgtatgttc tccccatgtc tctgggtttc ttctgggtgc tctggtttcc tcccacgtcc     3600

ccaaggtgtg tgtgtcaggt gcactggcgt gtctatgcgg tcccagtctg agtgagtgtg     3660

ggtgcgtgag ccccgtgaga ggaggacatc ctgtccaggg tgggtcccgc cttctgccct     3720

gagctgctgg gattgggctc tggccatctg caaccctgaa cgtgcaggtt ggagaacgaa     3780

tgaatacaaa ttttattgta aaataaaaat gtatataaag catatgagca cacaaatgga     3840

caataaatgc cacagcgcaa aagcgtgtag cgagcctgcc acgcttgtga ctggggaggg     3900

gctccgtata atctcacctt tgcaagcgtt tatttactga tgtatgcggc caccactgtg     3960

accaccatca cttaccgatt caccaaaact taggtaatat ggtcttattt ttgatttaat     4020

taaatatacg tgtagctcat gtatttcaca gtttaatatg agaagtgctt tggtctttat     4080

ttagaaattg ggtgatgttt ttgtgcccag caacatgctg taggaattta actcttgttt     4140

acatccatta gcctcatggt tttgcttcaa gtctcagctt ccaagaacct atcgatgact     4200

tactgtgcat ggtctgagac taagtaaagg aaatttccta aagctgtgaa atttgaattt     4260

tgctttaaat aaatggaact cacatgtg                                        4288


<210> 3118
<211> 1510
<212> DNA
<213> Homo sapiens

<400> 3118
cgcacccgcg ggagcggagc cgtggcgcgc tcgccccgga cgccggccgc ccctccgctc       60

gccctactga gcgagcggcc cggggcgccg aggggtccgc gccgcgcggg gcgcaccgcc      120

ctggccgcca tgtgctccca gctctggttc ctgacggacc ggcgcatccg cgaggactac      180

ccgcaggtgc agatcctgcg cgccctccgg cagcgctgct ccgagcagga cgtgcgcttc      240

cgggcggtgc ttatggacca gatcgccgtc accatcgtcg gcggccacct cggcctccag      300

ctaaaccaga aggccctcac cactttcccg gatgtggtgc ttgtacgggt acccacaccc      360

tcagtgcagt cagacagtga catcactgtc ctgcgacacc tggagaagct gggctgccgg      420

ttggtcaatc gcccacagag catcttaaat tgcatcaaca aattctggac gttccaagaa      480

ctggctggac atggggtccc catgccagac accttctcct atggtgggca tgaagacttt      540

tcaaaaatga ttgatgaagc tgagcccctg ggctacccag tcgtggtgaa gagcacacga      600

ggccaccggg gaaaagctgt ttttctggca agagataaac atcacctctc tgacatctgc      660

catctgatcc gccacgatgt gccctacctg ttccagaagt acgtgaagga gtcccatgga      720

aaggacatcc gggtggtggt ggtagggggc caggtcatag gctctatgct tcgctgctcc      780

actgatggac ggatgcagag caactgctct ctcggtggcg tgggcgtcaa gtgtccgctg      840

acagaacaag gcaagcagtt ggctattcag gtgtccaaca tcctaggcat ggacttctgt      900

ggcattgatc tccttatcat ggacgatggc tcctttgtgg tgtgtgaggc aaatgctaat      960

gttggcttcc tagcctttga ccaggcatgc aacttagatg tgggtgggat cattgcagac     1020

tataccatgt ccttgctgcc aaataggcag actggaaaga tggctgtcct cccaggactg     1080

tcgagtccaa gggagaagaa cgagccggat ggctgtgctt cagctcaggg agttgcagag     1140

agcgtctata ccatcaacag tgggtctacc tctagtgaaa gtgagcctga actgggagag     1200

atccgggatt cctcagcaag cacaatgggg gccccaccct ccatgctgcc cgaacctggc     1260

tacaacatta acaacaggat tgcttctgag ttaaaactta agtgaattcc tgctttttgg     1320

cagcatttaa accaaatcct actgcttccc tagtagtttt gagtgaataa aatctggact     1380

aatgtgattt catttgcaca gaaactagaa atcccatctg ggcactcagc attttttcta     1440

acgatgattt aagcaaatgg cctagctttg tggtttttac aaagacaaat ataaaaacac     1500

tcaagaacaa                                                            1510


<210> 3119
<211> 1783
<212> DNA
<213> Homo sapiens

<400> 3119
aactcctaac tgcagcggaa acgtgggagc cgcgcgggcc gctgtcgtcc caacccccgc       60

cgccctcgtc gcgcgcgggg cctccgcgcc cccggctgct gctcacgccc cgcccgggag      120

ccaggcagaa atactcagtg tcctcagtca cagaaacatc atccagtttt atggagtaat      180

tcttgaacct cccaactatg gcattgtcac agaatatgct tctctgggat cactctatga      240

ttacattaac agtaacagaa gtgaggagat ggatatggat cacattatga cctgggccac      300

tgatgtagcc aaaggaatgc attatttaca tatggaggct cctgtcaagg tgattcacag      360

agacctcaag tcaagaaacg ttgttatagc tgctgatgga gtattgaaga tctgtgactt      420

tggtgcctct cggttccata accatacaac acacatgtcc ttggttggaa ctttcccatg      480

gatggctcca gaagttatcc agagtctccc tgtgtcagaa acttgtgaca catattccta      540

tggtgtggtt ctctgggaga tgctaacaag ggaggtcccc tttaaaggtt tggaaggatt      600

acaagtagct tggcttgtag tggaaaaaaa cgagagatta accattccaa gcagttgccc      660

cagaagtttt gctgaactgt tacatcagtg ttgggaagct gatgccaaga aacggccatc      720

attcaagcaa atcatttcaa tcctggagtc catgtcaaat gacacgagcc ttcctgacaa      780

gtgtaactca ttcctacaca acaaggcgga gtggaggtgc gaaattgagg caactcttga      840

gaggctaaag aaactagagc gtgatctcag ctttaaggag caggagctta aagaacgaga      900

aagacgttta aagatgtggg agcaaaagct gacagagcag tccaacaccc cgcttctctt      960

gcctcttgct gcaagaatgt ctgaggagtc ttactttgaa tctaaaacag aggagtcaaa     1020

cagtgcagag atgtcatgtc agatcacagc aacaagtaac ggggagggcc atggcatgaa     1080

cccaagtctg caggccatga tgctgatggg ctttggggat atcttctcaa tgaacaaagc     1140

aggagctgtg atgcattctg ggatgcagat aaacatgcaa gccaagcaga attcttccaa     1200

aaccacatct aagagaaggg ggaagaaagt caacatggct ctggggttca gtgattttga     1260

cttgtcagaa ggtgacgatg atgatgatga tgacggtgag gaggaggata atgacatgga     1320

taatagtgaa tgaaagcaga aagcaaagta ataaaatcac aaatgtttgg aaaacacaaa     1380

agtaacttgt ttatctcagt ctgtacaaaa acagtaagga ggcagaaagc caagcactgc     1440

atttttaggc caatcacatt tacatgaccg taatttctta tcaattctac ttttattttt     1500

gcttacagaa aaacgggggg agaattaagc caaagaagta tatttatgaa tcagcaaatg     1560

tggtgcctga ttatagaaat ttgtgatcct atatacaata taggactttt aaagttgtga     1620

cattctggct ttttctttta atgaatactt tttagtttgt atttgacttt atttccttta     1680

ttcaaatcat ttttaaaaac ttacattttg aacaaacact cttaactcct aattgttctt     1740

tgacacgtag taattctgtg acatactttt tttttcttat agc                       1783


<210> 3120
<211> 2308
<212> DNA
<213> Homo sapiens

<400> 3120
agtcctccgc ccgggcgtcc ggaacagtcg acggcagact ccggcccgct gagccacccg       60

aggggtcccg tggcctccgc ggacccggaa tctgggccct cgcggacccg cgccccgccc      120

agtcgcccca gggcttcccc acacccacgg agtgaagtca gccgcggccc tgcctgggag      180

gaacttaccg tctaccggga aaggtggcca gcagatgtgt cgggcctggt gagagggtga      240

ggcgagacgg cccgatcgcc cagggccccg gaagctgcgg aggtcacccc cgcctggcct      300

tagctcaggg acaccctgga ttcacgtggg agcccctgct cctgcctccc ccgtcccacc      360

actgaggctg ttgggccagg ccagtcatgc tagaacggcc tcctgcactg gccatgccca      420

tgcccacgga gggcaccccg ccacctctga gtggcacccc catcccagtc ccagcctact      480

tccgccacgc agaacctgga ttctccctca agaggcccag ggggctcagc cggagcctcc      540

cacctccgcc ccctgccaag ggcagcattc ccatcagccg cctcttccct cctcggaccc      600

caggctggca ccagctgcag ccccggcggg tgtcattccg gggcgaggcc tcagagactc      660

tgcagagccc tgggtatgac ccaagccggc cagagtcctt cttccagcag agcttccaga      720

ggctcagccg cctgggccat ggctcctacg gagaggtctt caaggtgcgc tccaaggagg      780

acggccggct ctatgcggta aagcgttcca tgtcaccatt ccggggcccc aaggaccggg      840

cccgcaagtt ggccgaggtg ggcagccacg agaaggtggg gcagcaccca tgctgcgtgc      900

ggctggagca ggcctgggag gagggcggca tcctgtacct gcagacggag ctgtgcgggc      960

ccagcctgca gcaacactgt gaggcctggg gtgccagcct gcctgaggcc caggtctggg     1020

gctacctgcg ggacacgctg cttgccctgg cccatctgca cagccagggc ctggtgcacc     1080

ttgatgtcaa gcctgccaac atcttcctgg ggccccgggg ccgctgcaag ctgggtgact     1140

tcggactgct ggtggagctg ggtacagcag gagctggtga ggtccaggag ggagaccccc     1200

gctacatggc ccccgagctg ctgcagggct cctatgggac agcagcggat gtgttcagtc     1260

tgggcctcac catcctggaa gtggcatgca acatggagct gccccacggt ggggagggct     1320

ggcagcagct gcgccagggc tacctgcccc ctgagttcac tgccggtctg tcttccgagc     1380

tgcgttctgt ccttgtcatg atgctggagc cagaccccaa gctgcgggcc acggccgagg     1440

ccctgctggc actgcctgtg ttgaggcagc cgcgggcctg gggtgtgctg tggtgcatgg     1500

cagcggaggc cctgagccga gggtgggccc tgtggcaggc cctgcttgcc ctgctctgct     1560

ggctctggca tgggctggct caccctgcca gctggctaca gcccctgggc ccgccagcca     1620

ccccgcctgg ctcaccaccc tgcagtttgc tcctggacag cagcctctcc agcaactggg     1680

atgacgacag cctagggcct tcactctccc ctgaggctgt cctggcccgg actgtgggga     1740

gcacctccac cccccggagc aggtgcacac ccagggtctt aacgcccctg aggctgagcc     1800

ctgctgcaga acccagcgct cctggccttg ggccagcagc tgaagcccca tgctgtgtgg     1860

agcaaagagg tttcctgagc aggcacatcc cccggtcctt ctctgcattc caggcagctc     1920

caccaaagtc tgcgtgcaac gcccttcatt tgcatggaca cacgcaaccc tcggcgtttg     1980

tatggtcatt aacatgctcc tcccaccacg gaagaacttt cgaggcccgt accaaagtag     2040

atcctttatt caaaatctgt gggggttttt tgactgtttt tgctgacctg tgacctctca     2100

ctgaggacgg cagtccagga ccacccccag aggggttcaa agacctccga aaccagagac     2160

cacccccaca tacaggtcca tggagagggc ctggaccatc tggaccccca cggtcaggcc     2220

aagtcccaga taatagcacc agatgtttcc tgtccgactt ttggtctccc caaggcgacc     2280

agaggccgag ctgcccctac acaggcgc                                        2308


<210> 3121
<211> 955
<212> DNA
<213> Homo sapiens

<400> 3121
ccgagctcgg agccccgcgg gccgcgcccg ccgccggccc cacccatccg ggtcgaggag       60

gccgaggcca tggctgagac ggaggagcgg agcctggaca acttctttgc caagagggac      120

aagaagaaga agaaggagcg gagcaaccgg gcggcgagtg ccgcgggcgc agcgggcagc      180

gccggcggaa gcagtggagc cgcgggtgcg gcgggcggcg gggcgggcgc ggggacccgg      240

ccgggtgacg gcgggaccgc cagcgcgggg gctgcgggcc caggggccgc caccaaggct      300

gtgacgaagg acgaagatga atggaaagaa ttggagcaaa aagaggttga ttacagcggc      360

ctcagggttc aggcaatgca aataagcagt gaaaaggaag aagacgataa tgaaaagaga      420

caagatccag gtgataactg ggaagaaggt ggaggtggtg gtggaggtat ggaaaaatct      480

tcaggtccct ggaataaaac agctccagta caagcacctc ctgctccagt aattgttaca      540

gaaaccccag aaccagcgat gactagtggt gtgtataggc ctcctggggc caggttaacc      600

acaacaagga aaacaccaca aggaccacca gaaatctaca gtgatacaca gttcccatcc      660

ctgcagtcaa ctgccaagca tgtagaaagc cggaacaggt acttaaaatg aatgctacct      720

ggaattaaat gactacatat ggcacatcta catcttactt tagggacatg aattttttaa      780

aataaataaa atgggaagaa atgtaaatga catcagatgg aaatgtgttt tttggggtgg      840

cttttagaat aaatcccagc cttttcacca ctttgagagc acagctggct tgaatttaaa      900

cctccacgtg gacttgctcc tctgctctgt cttaaaaaat gtgtaaggga ccttg           955


<210> 3122
<211> 4747
<212> DNA
<213> Homo sapiens

<400> 3122
atttcctctt aatctgattg cagcttgaag gcagcccatt tccattaagt aggactgcat       60

ggcaagcagc cccaccaaag ggttgacaat gagcgtccca gtggctccta agaaatcatg      120

ttacactcag ttgcgggaca acagaaatgc agcaagaaat aataatgaaa gcatcttaag      180

tctgggagat acgaatgcca atcaaatcat gttggaggtc agctcctctc atgacgagtc      240

caagacatgt gacctgggag atgaaattgg aaatacaaat tcaagtgagc cagaaaaccg      300

tacccatttc cataaggaat ttcaccaact tcagggcttt gggaaaggct ctcaggctgg      360

ctctgccagc ctgaaagatt ttagactttc ttcaaccatt cagagggaac tcaatgaaga      420

gcacacagtg gagagaggca cagatagcct gcagaccacg cggagtattc agggaccaag      480

tctgtcgagt tggaggaatg tgatgagtga ggccagtcta gacgttttgg ctaaaaggga      540

tgctgaaatt ccccggcatg ttcccaagga taaactggca aagacccttg acaatgagga      600

actgaggagg cattctttgg aaagagcaag cagctctgta gctgcagtcg ggagcctgac      660

tccgcagcat ccacagcctc tatccctcga ctcccgggaa gcacggggtc agatacctgg      720

gggtggggag gggccacaga agacattgcc agaccacgct gtcccggcag ctttccctgc      780

aactgacagt acctcagagg gaaagagtgt gcgtcatcct aaaccatcta cctcagaaag      840

caagcagagc actccctcag agacccaaac agtgggggca catgtactgc aggtgtgcag      900

tgagcacaca tcacattccg cccatccaga gcctgctctg aatttgactt tggcatcgaa      960

ggaaatccca agtaaactgg aagcacaatt aggtcaggga aagggagagg ccaagctgga     1020

tctgaaatat gttcctccca ggagagttga acaggaggga aaggcagccc aggaagggta     1080

tctgggatgc cacaaggaag agaatctgtc agccttggag ggaagggatc catgtgggga     1140

agcacacccg gaagccaccg atgcacttgg ccatctgctg aacagtgacc tccaccacct     1200

tggggtggga agaggcaact gtgaagagaa gagaggagtc aacccagggg agcaggattc     1260

tctccacacc acccccaaac agggctctgc ttccttagga ggggctgata atcagcccac     1320

tggcaaaatt tcaccatgtg caggtgagaa gttgggtgaa aggacatcca gcagcttttc     1380

accaggtgac agtcatgtgg cttttattcc taataatctg actgacagca agcccttgga     1440

tgtcattgag gaggaaaggc ggttgggcag tgggaataag gacagtgtta tggttttggt     1500

gttcaatcct tctgttggag agaacaagac ggaggtgcct gagcccctgg accctcaaag     1560

tggccgctca gaagcacggg aaagcaaaga ggtcaccaca tctgttgctg aaaacaggaa     1620

ccttctagag aatgcagata agattgaaag cacctcagca agagcagatt cagttctcaa     1680

tattccagca cccctccacc cagagacaac tgtgaacatg acctaccagc ctacaacacc     1740

cagtagcagt tttcaggatg ttagcgtgtt cggtatggat gcggggtccc ccttggtagt     1800

tccaccccct actgatagtg cacgcttgtt gaacacgtcc cccaaagtgc ctgacaagaa     1860

cacttgcccc agtgggatcc ccaagcctgt cttcacacat tccaaggaca caccttcctc     1920

gcaggaggga atggagaact atcaggttga aaaaacagag gagaggacag aaactaagcc     1980

catcattatg cccaagccca agcatgtgag gcccaagatc atcacctaca tcaggaggaa     2040

tccccaggcc ctgggccagg tggacgcctc gctggttcca gtggggcttc catatgcccc     2100

gcccacatgt accatgcctc ttccccacga agagaaggca gcaggtggtg acctgaagcc     2160

atctgccaac ctctatgaga aattcaagcc agacctgcag aagccaaggg tcttcagttc     2220

cggattgatg gtgtctggaa tcaagccccc gggacatcct ttcagtcaaa tgagtgaaaa     2280

gtttttgcag gaggttacag accaccctgg aaaagaagag ttttgttctc ctccctatgc     2340

tcattatgaa gtccctccaa ctttctatcg gtcagccatg ctccttaagc cccagctagg     2400

attgggtgca atgtcccgtt taccatctgc aaagagcagg attctgattg caagtcagag     2460

gtcttcagcg agcgccatcc acccaccagg acccataaca acagccacca gtctctacag     2520

ttccgatcct tcagcagatt taaagaaagc ttccagttca aatgctgcaa aatccaatct     2580

cccgaaatct ggtctccgtc ctcccggata ctcacgtctc ccggcagcca aactggcggc     2640

atttggcttt gtccggagct ccagcgtctc ctcagtctcc agcacccagt ccggggacag     2700

tgcacagcca gagcagggcc ggccagccac ccgttcaacc tttgggaatg aagaacagcc     2760

agttctgaag gcatctctgc cttctaagga cacacccaag ggggccggcc gggtggcccc     2820

tccagcatcc tccagtgtga cagcaccccg caggagttta cttccagcgc caaaatccac     2880

ttccacaccc gctggaacaa agaaagatgc tcagaaagat caagatacga ataaacctgc     2940

tgtttcatct cctaagagag tagcagcttc aaccaccaag cttcattcac caggataccc     3000

aaagcagagg actgcggcag ctcgaaatgg gtttccgccc aagccggacc cgcaggcccg     3060

tgaggctgag cggcagctgg tgctgcggct gaaggagcgg tgtgagcagc agaccagaca     3120

gctgggcgtt gcgcaagggg agctgaagag ggccatctgc ggctttgatg ccctcgccgt     3180

ggccacgcag catttcttta gaaagaatga aagtgccctt gtgaaagaaa aagagctgtc     3240

aatcgaactt gcaaacatca gggatgaagt tgccttccat acagcaaagt gcgagaaact     3300

acaaaaggag aaggaggagc tggagaggcg gttcgaggac gaggtgaaga ggctgggctg     3360

gcagcagcag gccgagctcc aggagctgga ggagcggctg cagctgcaat tcgaggcgga     3420

aatggcgcgc ctgcaggagg agcacggtga ccagctgctg agcatccggt gtcaacacca     3480

ggagcaggtg gaagatctca ccgccagcca tgatgctgct ctcctagaga tggaaaataa     3540

ccacacagtt gccatcacaa tcctgcagga tgaccacgac cacaaagtcc aagaattgat     3600

gtccactcat gagcttgaaa agaaagaatt ggaagaaaat tttgaaaaac tgcggctgtc     3660

attgcaggac caggtggaca cgctgacctt ccagagccag tctctgcggg acagagcccg     3720

ccgcttcgaa gaggccttga ggaagaacac agaggagcag ctggagattg cattggctcc     3780

ttatcagcac ttggaagaag acatgaagag tctgaagcag gtattagaaa tgaagaatca     3840

gcaaatacac gagcaagaaa agaagattct tgagctggaa aagctggcag aaaagaacat     3900

tatcctagaa gaaaagatcc aggttctcca acagcagaac gaagacctca aagcaaggat     3960

tgaccaaaac acagttgtca ccagacagct gtcggaggaa aatgctaacc tccaggaata     4020

tgttgagaag gaaacccagg agaagaagag attgagccga accaatgaag agctgctttg     4080

gaagctccaa actggggacc cgaccagtcc gattaaactc tcgcccacat ctcccgttta     4140

ccgcggctcc tcctcggggc cctcctctcc ggccagagtc agcacaacac ccagatgacg     4200

ccactacacg gcctgcggga gctccggctt ctcgtcctcc ggtctccacc ctgagggagc     4260

accgacccgg tgccgccgga gctggccctg tgcgcatgct cagtagctgc gaatgcatcc     4320

taggcgcgtc ctcctctgat ccccgtgtaa gactgccctg gtgtcggcac ttaggaatgt     4380

gtaaatggta aagtctgatg tgcaaacgtt ttaccatagt tagagccaaa agaaagacac     4440

ttgcaattgt tcttgagcaa tgaactttca ctgcagaatt tcaggttagt tacaaaaagc     4500

tcagttttca atatacattg aataatcatt gtgtactgca ccgatatgtg tgtatattta     4560

gatatacgta tatacacatg ctgcggttct gaatttcatt ttttataaca tgaagtgctg     4620

acatatttta gtgaaggtca gcagttttct aacttgtgcc taagaattat tgggaaatga     4680

aaatgcattt ctatctagct tcccaggaat atttctaccc aaaatagaaa aaggaaaaaa     4740

aaaaaga                                                               4747


<210> 3123
<211> 1833
<212> DNA
<213> Homo sapiens

<400> 3123
gttatgaaaa ttaaccagga gcgagcagag gagttgcagg aagcagagag gttcagcaga       60

aaggcagcac aagcagccag agatctcacc cgagcagaag ctgagatcga actcctgcag      120

aatctcctca ggcagaaggg ggagcagttt cgacttgaga tggagaaaac aggtgtaggt      180

actggagcaa actcacaggt cctagaaatt gagaaactga atgagacaat ggaacgacaa      240

aggacagaga ttgcaaggct gcagaatgta ctagacctca ctggaagtga caacaaagga      300

ggctttgaaa atgttttaga agaaattgct gaacttcgac gtgaagtttc ttatcagaat      360

gattacataa gcagcatggc agatcctttc aaaagacgag gctattggta ctttatgcca      420

ccaccaccat catcaaaagt ttccagccat agttcccagg ccaccaagga ctctggtgtt      480

ggccttaagt actcagcctc aactcctgtt agaaaaccac gccctgggca gcaggatggg      540

aaggaaggca gtcaacctcc ccctgcctca ggatactggg tttattctcc catcaggagt      600

gggttacata aactgtttcc aagtagagat gcagacagtg gaggagatag tcaggaagag      660

agtgagctgg atgaccaaga agaaccccca tttgtgcctc ctcctggata catgatgtat      720

actgtgcttc ctgatggttc tcctgtaccc cagggcatgg ccctgagaat gaagtttcta      780

gattagaaga cataatgcag catttaaaat caaagaagcg ggaagaaagg tggatgagag      840

catccaagcg gcagtcggag aaagaaatgg aagaactgca tcataatatt gatgatcttt      900

tgcaagagaa gaaaagctta gagtgtgaag tagaagaatt acatagaact gtccagaaac      960

gtcaacagca aaaggacttc attgatggaa atgttgagag tcttatgact gaactagaaa     1020

tagaaaaatc actcaaacat catgaagata ttgtagatga aattgagtgc attgagaaga     1080

ctcttctgaa acgtcgctca gagctcaggg aagctgaccg actcctggca gaggctgaga     1140

gtgaactttc atgcactaaa gaaaagacaa aaaatgctgt tgaaaagttc actgatgcca     1200

agagaagttt attgcaaact gagtcagatg ctgaggaatt agaaaggaga gctcaggaaa     1260

ctgctgttaa cctcgtcaaa gctgatcagc agctaagatc gctccaggct gatgcaaagg     1320

atttggagca gcacaaaatc aagcaagaag aaatcttgaa agaaataaac aaaattgtag     1380

cagcaaaaga ctcagacttc caatgtttaa gcaagaagaa ggaaaaactg acagaagagc     1440

ttcagaaact acagaaagac atagagatgg cagaacgcaa tgaggatcac cacctgcagg     1500

tccttaaaga atctgaggtg cttcttcagg ccaaaagagc cgagctggaa aagctgaaaa     1560

gccaggtgac aagtcagcag caggagatgg ctgtcttgga caggcagtta gggcataaaa     1620

aggaggagct gcatctactc caaggaagca tggtccaggc aaaagctgac ctccaggaag     1680

ctctgagact gggagagact gaagtaactg agaagtgcaa tcacattagg gaagtaaaat     1740

ctcttctgga agaactgagt tttcagaaag gagaactaaa tgttcagatt agtgaaagaa     1800

aaactcaact tacacttata aagcaggaaa ttg                                  1833


<210> 3124
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3124
aacagaccgc cgtgagagag gaggggcgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg tgttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cgaagtcctc      180

accagtgaac ggagacctct ctgaactaag gataccatgg ccacgtcagc cccactacgg      240

agcctggaag aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc      300

attgactgtg gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg      360

agccgccccg tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg      420

tggcaactgg ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag      480

ccgggagagg tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag      540

ctgcactact actgtgagga cgacgggaag ctgctgtgcg tg                         582


<210> 3125
<211> 559
<212> DNA
<213> Homo sapiens

<400> 3125
ggcgaggagg ggaatttcct tgtgcctcca ttcccgggag gggggagcgg cgttggaggc       60

caccgtttcc agcatcaaca acagcaactt gtgattggcg gtgaccggat attcagttgc      120

acatccccac atcaatgcac tgccaatgac agcaaaacca acttctcctc agccttgtga      180

agaggatgag gaccttcagg atgattcact tccatttaat gaatgggtta tatcctgtgt      240

tgtgacctca tggtttaagt gggaataaag atgagtataa gcagtgatga ggtcaacttc      300

ttggtatata gatacttgca agagtcagga ttttctcatt cagcatttac ctttggtata      360

gaaagccata tcagtcagtc caatataaat ggtgccctcg tcccacccgc tgcattgatt      420

tctatcatcc agaaaggtct acagtatgta gaagcagaag ttagtattaa tgaggatggt      480

accttgtttg atggtcgacc aatagagtct ctgtccctga tagatgccgt aatgcctgat      540

gtagtacaaa caagacaac                                                   559


<210> 3126
<211> 3926
<212> DNA
<213> Homo sapiens

<400> 3126
gcacttccgg gccggccgat tccgcgcgtc tccgcccatc atggcgctcg tgccagtgtc       60

ccgtgggcta cccactcctg tcatgtcctt tgggctggtg caggccagat cttctagggc      120

cgtagccctg agaggagcgc ctggagagga aacggcgcgc catgcacctc acacggcccc      180

tcagacctca cggcgaggcc ctatcagggt aatggtgtcc gccggactcg cacaacactc      240

cgccggactc gcacaacact ccgccgcact cgcacaagac tccgccgcgg cgacctctac      300

tgaaagaccc ccagtcctgg tgtcgcccga aggcccagga aaccgtgctt ccgcgcttct      360

cccccagaac gtgggaagct gccgctttac cctcatttta ccccagggtc gcaaaacatc      420

tcaccgtagt tgaagccagc aagccggacc aggcgtcccg gccaagccac gtgcgcgccc      480

cgcgccgcga gtgctcgccc cgcccctagg gaggagccgg ccgacccccg gccacttagc      540

agtgccgcag ccgacggggt gcggttcggc gctcccaggt tcctttcctc actgcacgct      600

cttgcccctc ctcttttctc tcctgcccgt gttcttcccg ccgcctgacc tggcccgccc      660

gcctttccag tctggccggg cgggggcctg aagcacggcg gctcgggccg tgggaccgtg      720

ttcacaccct ttccagaaat tcttggctgg taaccgcgaa accgactgga gcaggagctg      780

ggagaactgg agaaaactgc tctaatctca cttgactcca gctaggagct gatgctgcat      840

cgtaataaca tttgcagagc gctttcacag gcgctggagt gacttgtctg agattcctcc      900

agaactgagc cctttgttgg aaccataccc cagcccatgg tcccatgact aggtggatag      960

tactccttgt acctcctgca acccagaacc ctggctgacc actttgaagg aggatgctcc     1020

agcaggtcaa tggccacaat ccggggtctg atggccaagc cagggagtac ctcagagaag     1080

acctgcagga gttcctgggt ggggaggtcc tgctgtacaa actggatgac ctcaccaggg     1140

tgaatcctgt gacactagag acagtcctga ggtgcctgca ggcccggtac atggcagaca     1200

cattctacac caatgctggc tgcaccctgg tagccttgaa ccccttcaag cctgttcctc     1260

agctctactc gcccgagcta atgagagagt accatgctgc gcctcagccc cagaaactga     1320

agccccatgt gttcactgtg ggtgaacaga cctacaggaa tgtcaagagc ctgattgaac     1380

cagtcaacca gtctattgtt gtcagtggag agagtggtgc tggaaagaca tggacgtctc     1440

gctgcctaat gaagttctat gctgtggtgg ccacctcacc tgcatcttgg gagagccaca     1500

agattgcaga gaggatagaa cagaggatcc tgaactccaa ccctgtcatg gaagcttttg     1560

ggaatgcgtg tacactgagg aataacaaca gcagtcgctt tgggaagttc atccagctcc     1620

agctgaacag ggctcagcaa atgactggag ccgcagtcca gacctacctc ctagagaaaa     1680

ctcgagtggc ctgccaggct tccagtgaga ggaacttcca catcttctat cagatttgca     1740

aaggagccag tgaggacgag aggctccagt ggcaccttcc tgagggagct gccttctcct     1800

ggctgcccaa cccagagagg agcttagaag aggattgttt tgaggtgacc agagaggcca     1860

tgctccattt gggcattgac acccctaccc agaacaacat ctttaaggtc ctagctggac     1920

tgctgcacct tggcaatatc cagtttgctg cctccgagga tgaagcccag ccctgccagc     1980

cgatggatga tgccaagtac tctgtcagga cggcagcctc gctgctgggg ctcccagagg     2040

acgtgctgct ggagatggtg cagattagaa ccatcagggc aggcagacag cagcaggtgt     2100

tccggaagcc ctgcgcccga gccgagtgtg acacccgtag agactgcctg gccaaactga     2160

tctatgcgcg gttgtttgac tggctggtat cagtgatcaa cagcagcatc tgtgcagaca     2220

ccgactcgtg gaccactttc ataggcctgc tggatgtgta tggatttgaa tcatttcctg     2280

acaacagtct ggaacagttg tgcatcaact acgccaatga gaagctgcag cagcattttg     2340

tggctcacta cctaagggcc cagcaggagg aatacgcagt tgagggcctg gagtggtcat     2400

tcatcaacta ccaggacaac cagccctgtt tggatctcat tgagggaagc cccatcagca     2460

tctgctccct cataaatgag gaatgccgcc tcaatcgacc cagcagcgca gcccagctcc     2520

agacacgcat tgagactgcc ctggcaggca gcccctgcct gggccacaat aagctcagcc     2580

gggagcccag cttcattgtg gtgcattatg cggggcctgt gcggtaccac acagcaggcc     2640

tggtggagaa gaacaaggac cctatcccac ctgagctgac caggctcctg cagcaatccc     2700

aggaccccct gctcatgggg ctgtttccta ctaaccccaa agagaagacc caggaggaac     2760

cccctggcca gagcagggcc cctgtgttga ccgtggtgtc caagttcaag gcctcactgg     2820

agcagcttct gcaggtccta cacagcacca cgccccacta cattcgctgc atcaagccca     2880

acagccaggg ccaggcgcag acctttctcc aagaggaggt cctgagccag ctggaggcct     2940

gtggcctcgt ggagaccatc catatcagtg ctgctggctt ccccatccgg gtctctcacc     3000

gaaactttgt agaacgatac aagttactaa gaaggcttca tccttgcaca tcctctggcc     3060

ccgacagccc atatcctgcc aaagggctcc ctgaatggtg tccacacagc gaggaagcca     3120

cgcttgaacc tctcatccag gacattctcc acactctgcc ggtcctaact caggcagcag     3180

ccataactgg tgactcggct gaggccatgc cagcccccat gcactgtggc aggaccaagg     3240

tgttcatgac tgactctatg ctggagcttc tggaatgtgg gcgtgcccgg gtgctggagc     3300

agtgtgcccg ctgcatccag ggtggctgga ggcgacaccg gcaccgagag caggagcggc     3360

agtggcgggc cgtcatgctc atccaggcag ccattcgttc ctggttaact cggaaacaca     3420

tccagaggct gcatgcagct gccacagtca tcaagcgtgc atggcagaag tggagaatca     3480

gaatggcctg ccttgctgct aaagagctgg atggtgtgga agaaaaacac ttctctcaag     3540

ctccctgttc cctgagcacc tcgccgctgc agaccaggct cctggaggca ataatccgcc     3600

tctggcccct gggactggtc ctggccaata cggctatggg tgtaggcagc tttcagagga     3660

aattagtggt ctgggcttgc ctccagctcc ccaggggcag ccccagtagc tacactgtcc     3720

agacagcaca agaccaggct ggtgtcacgt ccatccgagc gctgcctcag ggatcgataa     3780

agtttcactg cagaaagtct ccactgcggt atgctgacat ctgccctgaa ccttcaccct     3840

acagcattac aggctttaat cagattctgc tggaaagaca caggctgatc cacgtgacct     3900

cttctgcctt cactgggctg gggtga                                          3926


<210> 3127
<211> 6050
<212> DNA
<213> Homo sapiens

<400> 3127
cgttcacacc tcctttccga gtatctgcat gccttgctgg cccagagcac aagaccccca       60

ttgtgctccc ccggctcaga atccaaggaa agaaaggaag cgaagcctct gcattgagtt      120

ctaggacagc tgagacactt ggattggact taatcttaaa cctctggagt tcaagacctt      180

ttaaaaaggg ctaaataaac aatctctaca tgtaaaaggc cactgactcc tacttcctct      240

gtatagagca actgttgaac tcagctgcct gtagatagcg gtgggtgtgc tcgcaaacgt      300

gccgccatgt ctgttacgct aacatctgtg aagagagtgc aaagttctcc aaacctattg      360

gctgcagggc gtgattctca gtcaccagac tcagcttgga gatcttacaa tgatggcaat      420

caggagacac tgaacggaga tgctacatat tcctctcttg cagcaaaagg ttttagaagc      480

gttcgaccaa acctacaaga taaaagatca ccaactcaga gccagataac agtgaatgga      540

aactcaggag gtgccgtgag tcccatgagt tactatcaga ggccgttttc cccctcggca      600

tattctctcc cagcctcact caactccagc attgtcatgc agcacggcac atccctcgat      660

tccacagaca catatcccca gcatgcgcag tctctggatg gcaccaccag cagctctatc      720

cccctgtacc gatcctcaga ggaagagaag agagtgacag tcatcaaagc cccgcattac      780

ccagggatcg ggcccgtgga tgaatccgga atccccacag caattagaac gacagtcgac      840

cggcccaagg actggtacaa gacgatgttt aagcaaattc acatggtgca caagccggat      900

gatgacacag acatgtataa tactccttat acatacaatg caggtctgta caacccaccc      960

tacagtgctc agtcacaccc tgctgcaaag acccaaacct acagacctct ttccaaaagc     1020

cactccgaca acagccccaa tgcctttaag gatgcgtcct ccccagtgcc tcccccacat     1080

gttccacctc cagtcccgcc gcttcgacca agagatcggt cttcaacaga aaagcatgac     1140

tgggatcctc cagacagaaa agtggacaca agaaaatttc ggtctgagcc aaggagtatt     1200

tttgaatatg aacctggcaa gtcatcaatt cttcagcatg aaagaccagc ctccttgtat     1260

cagtcctcta tagacagaag cctggaaaga cccatgagtt ctgcaagcat ggccagtgac     1320

ttcaggaagc ggaggaagag cgagcctgca gtgggtccac cacggggctt gggagatcaa     1380

agtgcgagca ggactagccc aggccgagtg gacctcccag gatcaagcac cactcttaca     1440

aagtctttca ctagctcttc tccttcttcc ccatcaagag caaaaggtgg ggatgatagc     1500

aaaatatgtc catccctttg cagttactca gggctcaacg gcaacccctc cagtgagtta     1560

gattactgta gcacttacag acagcacttg gatgtccctc gggactcacc aagagccatt     1620

agtttcaaga acggctggca aatggcccgg caaaacgcag aaatctggag cagcacggaa     1680

gaaaccgtct ctcccaaaat caaatcccgg agctgtgacg atctcctaaa cgacgactgc     1740

gatagcttcc cggacccgaa agtcaagtcg gaaagcatgg gctccctgtt atgtgaggag     1800

gactccaagg agagctgccc catggcgtgg gggtccccct acgtcccgga ggttcgcagt     1860

aacggcagat caaggatcag acacaggtca gcccgcaacg ccccggggtt cctgaagatg     1920

tacaagaaaa tgcaccgcat caaccgcaag gacctgatga actccgaggt gatctgctcc     1980

gtgaagtcca ggattctgca gtacgagagc gagcagcagc acaaggacct gctgcgcgcc     2040

tggagccagt gctccacgga ggaggtgccc cgggacatgg tgcccacacg catctccgaa     2100

ttcgaaaagc tgatccagaa gtccaaatcc atgccaaatt taggggatga catgctgtct     2160

cccgtaaccc tagaaccacc gcaaaatggc ctatgtccca agaggcggtt ttccattgag     2220

tatttgctgg aggaagaaaa tcaaagcggc ccccccgctc ggggccggcg aggctgccag     2280

tctaacgccc tggtgcccat tcacattgaa gtcaccagcg atgagcagcc ccgagcacac     2340

gtggagtttt ccgacagcga ccaggacggg gttgtgtccg accacagtga ctacattcac     2400

ctagaggggt catccttctg cagtgaaagt gactttgatc acttttcctt cacatcctcc     2460

gaaagctttt acggatccag ccaccaccac caccatcacc accaccacca ccaccgccac     2520

ctcatcagct cctgcaaagg caggtgcccg gcctcctaca ctcgatttac cacaatgtta     2580

aaacacgaaa gagccagaca cgaaaacacc gaggagccca gaaggcaaga aatggaccct     2640

ggcctttcta aacttgcttt tctagtcagt cctgtgcctt tccggaggaa aaaaaattcg     2700

gctcctaaga aacagactga aaaggcaaaa tgtaaagcat ctgtgtttga ggctctggac     2760

tctgccctta aagacatctg tgaccaaatt aaagctgaaa agaaaagggg gagcttgccg     2820

gacaacagca tcctgcaccg cctcatcagt gagctgctgc cagatgttcc cgagaggaac     2880

tcatccctga gagcgctgag gaggagcccc ctgcaccagc ctctccaccc actgcctccc     2940

gatggtgcta ttcattgtcc accctaccag aatgactgcg ggagaatgcc ccgcagtgcc     3000

tctttccaag acgtggacac agccaacagc agctgccacc accaagaccg tggcggtgca     3060

ctccaagacc gtgagtcccc tagaagttac tcatccactt tgactgacat ggggagaagt     3120

gcaccaaggg aaagaagagg aactccagaa aaagagaaat tgcctgcaaa agctgtttat     3180

gattttaagg ctcagacatc taaggagttg tcatttaaga aaggagatac tgtctacatc     3240

ctcaggaaaa ttgatcaaaa ttggtatgag ggagaacacc acgggagagt gggcatcttc     3300

ccgatctcat acgtagagaa actcacacct cctgagaaag cacagcctgc aagaccacct     3360

ccgccagccc agcccggaga aatcggagaa gctatagcca aatacaactt caacgcagac     3420

acaaatgtgg agctgtcact gagaaaggga gatagagtta ttcttcttaa aagagttgat     3480

caaaactggt atgaaggtaa aatcccagga accaacagac aaggcatctt ccctgtttcc     3540

tatgtggagg tcgtcaagaa gaacacaaaa ggtgctgagg actaccctga ccctccaata     3600

ccccacagct attctagtga taggattcac agcttgagct caaataagcc acagcgtcct     3660

gtgtttactc atgaaaatat tcaaggtggg ggggaaccgt ttcaggctct gtataactat     3720

actcccagga atgaagatga gctggagctc agagaaagtg atgtcattga tgtcatggaa     3780

aagtgtgatg acggctggtt tgtggggacc tcaagaagaa ccaaattctt tggtactttc     3840

cccggaaact acgtcaagag gctgtgaatt gcgctccctc cttctgtaga ggccgcctgc     3900

cagccatgca cctgcgtcaa cgcgcctgaa acaccccgcg ggcctcccgt tgtcatgcct     3960

tacggtttcc aatgcgccgt caccatctcc acctgccacc aaaccaccag cagagtagcc     4020

gccgctgctg tgagcctggg gacgacatgg caggctggtc cccctccgtg aaagtgtgga     4080

ttcctacttc ctgctctaag ctttgacacg tcaaaatgtg ggatcagaaa gaaaaaaatc     4140

atgatattta aaaatggtca aatatttgag gcaaaaaaaa aaaaaaaaag tgtctccagg     4200

aggctgtcca gcctcgtggc tccatttcaa catctccccc caggcgatgt tctcccccaa     4260

gacgaccaga aaattgttta ttggggaatg ctgtggtttg cattttcata ttcttcgctt     4320

ggcagtgtgt attcttttca caagtttgcc tagtgtcttg gtttacacaa tatgacaact     4380

gtaactgtac tttagctatt gtttgcctgc acatacatgt tgtaatatgc acagtgatta     4440

caacctttaa agcaagagga ggcgagttaa tttggatgag tgtgattttg ctgattgaat     4500

gtgagttttc aaataggagt ctttttctgc aatttgtttg cattttttag aagtgcaaac     4560

agtaagtaaa taaaagcctt cggtaataat catgacaata caagaggctg agctaggcta     4620

caggggaaaa ctattgtgtt gtaaagttgc atcgctattt tatattaaaa tgtaatgatc     4680

agcatcatga acaatgagct cttagtgttt tatttatctg aaaaaatgta agtaaaagca     4740

gtgttagtga gaggtgcaaa gaattattct aacagacacc tgaaagtatc tgtaagcaat     4800

actagtaggt aagatttcac tgtgtgtaca catacacatt tgagattgta tgagaacata     4860

taatccatat gatatgttgt acattttatg gaaatgtaat agaatctcac acattatttt     4920

atagaaatag agtacagaag catcacaagt attaaagttg gttttagcaa ggattaggat     4980

tactacaatt atttttacta taataattat ttttcttcta tggaactcag aatcctggct     5040

acatttgagg acaggaatat gttgagcctg attttcctgg tgtgtgtaaa atatttccta     5100

ggaataaatt aggcactttt tagaagcaat gttaaatcat tcaggtttta ttttctgccc     5160

tgaagcagaa atttaaaaaa tgatattggg acctggaagg tttaatatgg ttcacagtgc     5220

ctgaattaca cctgctccga aaactagctt tgtatttctt atgactttgc ataagaactg     5280

ttcatctttg gatcttgagc accttacaga taaaactttt tatggcatct ctttcatgga     5340

cagtgatatt gatcttttca caatgtacgt agcctctaga attttgtaca tatgtttgct     5400

ctttttttgt acagactagt tgttgagaaa acaggggcgt ttcctaattt ggtctttatc     5460

ctgcgacaac actttcagca gactagcctc tccttatctc acagatcaca agcaccccta     5520

gatagtgtga ttctgtcaga tagcatttat gcaaaaatct atgaagttaa aagatcgtag     5580

aagccaaatg aaatgtacat atctactgac tgatgacaag ggaatttcat taggaagaag     5640

gtaaagaaac atcgttgagt agcctacctt gatttctgtc aagttcataa ccagcttcat     5700

attttaaagg cttcaggttt gaaattaagt caactgcatg cagctttgct gataaatgaa     5760

taattctctt tgatgccatt tatgagaaaa gacttcaata tctgttgcct gtcatattta     5820

agaaaaatta ctgtttctac tctctgtatc tgattttaaa agaaaaaact attcatacct     5880

ggcttccagg taattgactt tgaattctta caagcaaagg tcattgtgtt tttcttgaat     5940

agacatctaa taaattttgc ttggaagtat acttcagttt ttcttcttga catttatctt     6000

tataaaaatt gtgtatttta ttccaacttg ttaaactaag agaaaatgca                6050


<210> 3128
<211> 884
<212> DNA
<213> Homo sapiens

<400> 3128
atcttgagtg agggcacgct ctccttagag gggcggaaca gtttttggca ccttatcgcg       60

agcggcagct tatgcaagag tgacttaaaa aagaaaggca ggtccggagc caggggctaa      120

gtagcggtgc ggtttctttt tctggattag tttccccatc ttgcctaaaa atgtcctagt      180

ctagtctttt tagcagaact ccactcccta aacatgtcag aactacactt cccatcaagg      240

gtcagaaaga aacttccggc acagtctttt cccagcattc cttgtttact tccgggttta      300

ttactactga aggaagaacg ccagatcaga aaagggagct caggtacctt ccagagagtg      360

agacccagcg cccttgtctc gcacccagta ggctttcatc cccgccatgg cggagctgat      420

ccagaagaag ctacagggag aagtggagaa atatcaacag ctacagaagg acttaagtaa      480

atccatgtcg gggaggcaga aacttgaagc acaactaaca gaaaataata tcgtgaaaga      540

ggaactggcc ctgctggatg ggtccaacgt ggtctttaaa cttctgggtc cggtgctagt      600

caaacaggag ctgggggagg ctcgggccac agtagggaag aggctggact atatcacagc      660

tgaaattaag cgatacgaat cccagcttcg ggatcttgag cggcagtcag agcaacagag      720

ggagaccctt gctcagctgc agcaggagtt ccagcgggcc caggcagcaa aggcaggggc      780

tcctggcaag gcctgacccc atggtggggg gaggggaggg gaggggaggg aatgaggcag      840

ctctaggatc tatactgtag ctaataaaat gtaaaaacac ctgg                       884


<210> 3129
<211> 694
<212> DNA
<213> Homo sapiens

<400> 3129
ccgttcccaa gctggtttga aactaggggt cgggctcggc cgtcgtcgtt gtttgtcgcc       60

gcatccccgc ttccgggtta ggccgttcct gcccgccccc tcctctcctc ccttcggacc      120

catagatctc aggctcggct ccccgcccgc cgcagcccac tgttgacccg gcccgtactg      180

cggccccgtg gccaccatgt ccctgcacgg caaacggaag gagatctaca agtatgaagc      240

gccctggaca gtctacgcga tgaactggag tgtgcggccc gataagcgct ttcgcttggc      300

gctgggcagc ttcgtggagg agtacaacaa caaggttcag cttgttggtt tagatgagga      360

gagttcagag tttatttgca gaaacacctt tgaccaccca taccccacca caaagctcat      420

gtggatccct gacacaaaag gcgtctatcc agacctactg gcaacaagcg gtgactatct      480

ccgtgtgtgg agggttggtg aaacagagac caggctggag tgtttgctaa acaataataa      540

gaactctgat ttctgtgctc ccctgacctc ctttgactgg aatgaggtgg atccttatct      600

tttaggtacc tcaagcattg atacgacatg ctgtttccag tggccagtat gtctttcatt      660

gctttgcacc cactgttacc agaagctgct ctag                                  694


<210> 3130
<211> 1284
<212> DNA
<213> Homo sapiens

<400> 3130
cggtaccaca gcttctcgtc cgcgtcgaga ttacagccac ggccttcagg agtgaccata       60

gacgaatcct ttctcacaga agacaagagc acccagaatc gcaagcttct tcagaaacga      120

aggacgctgg tgaccaaact gaggaagaac ttggctgagg agtacctgca ctacctcagt      180

gagcgagatg cctgtaagat cctcatcgca gacctgaatg agctgcggta ccagcgggag      240

gacatgtcat tagcccagtc gccaggcatc tggggggagg accctgtgaa gttaaccctg      300

gctcttaaga tgacccggca agacctgacc cgcacgcaga tggaactcaa caacatgaag      360

gccaactttg gagatgtggt ccccaggagg gactttgaaa tgcaggagaa gaccaacaag      420

gatcttcagg agcagctgga caccctgaga gccagctacg aggaggttcg caaggagcat      480

gagatcctca tgcagctgca catgagcacg ctgaaggaac gggaccaatt cttctctgag      540

ctgcaggaga tccagcgcac ttccacgccg cggcctgact ggaccaagtg caaagatgtg      600

gtggctgggg gcccagagcg ctggcagatg ctggctgagg gcaagaacag cgaccagctg      660

gtggacgtgc tcctggaaga gattggttcg gggctgctgc gggagaaaga cttcttccct      720

ggtctgggct atggggaagc catccctgct tttcttcggt ttgatggcct cgtggagaac      780

aagaagccaa gcaagaagga cgtggtcaac ctcctcaagg atgcctggaa ggaacgtctt      840

gctgaggagc agaaagagac gttcccagat ttcttcttca atttcctgga gcatcgcttt      900

gggcccagtg atgccatggc ctgggcttat actatttttg aaaatatcaa gatcttccac      960

tccaacgagg ttatgagtca gttctatgca gtcttgatgg gaaagcggag tgagaatgtg     1020

tatgtcaccc agaaggagac agtagcccag ctgctgaagg agatgacaaa tgctgacagt     1080

cagaacgagg ggctactaac catggagcag ttcaacactg tcctcaagag taccttccct     1140

ctcaagacag aagagcaaat ccaggagctg atggaggcag ggggctggca tcccagcagc     1200

agcaatgcag acttgctcaa ctaccgctca ctgtttatgg aggatgagga gggccagagt     1260

gagccctttg tgcaaaaact ctgg                                            1284


<210> 3131
<211> 268
<212> DNA
<213> Homo sapiens

<400> 3131
cggctgcgcg agcggaggga ggcggagcgg gatgagtggg tgttccggca gggatgtggt       60

cattgacggc cagtgagggc gagagtacca cggcccactt cttccttgga gctggagatg      120

aggggctggg cacccgtgga ataggcatga ggccagaaga gagtgacagc gagctccttg      180

aggatgagga ggatgaagtg cctcctgaac ctcagatcat tgttggcatc tgtgccatga      240

ccaagaaatc caagtccaag ccaatgac                                         268


<210> 3132
<211> 2060
<212> DNA
<213> Homo sapiens

<400> 3132
gcacagctgc ccgccggaag aaccgagctt ggctgtgttt atctcgttgg ggactaaggc       60

gtcggttggc gcgcaacggg ttctaggctg caggcagctc gaggacccgc ggccccgccc      120

cggctcggcc tggcagtcct ggcagcatac caggcacagc tgtcaaagga actccttgtg      180

cctgtggggg gccctgggtg accccaatga caacaactca gcttgacagg agctccctgt      240

gaggggctaa ccaaccgcgg taacatggag gtccctgtcc tggatcaata gcagaggcag      300

caggccgtgc cgggggggca tgttgctgta accagtggcc caggggatgt tacggtggac      360

agtgcacctg gagggcgggc cccgcagggt gaaccatgct gcagtggctg tcgggcatcg      420

ggtatactcc ttcgggggtt actgctctgg tgaagactat gagacactgc gtcagataga      480

tgtgcacatt ttcaatgcag tgtccttgcg ttggacaaag ctgcccccgg tgaagtctgc      540

catccgtggg caagctcctg tggtacccta catgcgctat ggacactcaa ccgtcctcat      600

cgacgacaca gtcctccttt ggggcgggcg gaatgacacc gaaggggcct gcaatgtgct      660

ctatgccttt gacgtcaata cgcacaagtg gttcacaccc cgagtgtcag ggacagttcc      720

tggggcccgg gatggacatt cagcctgtgt cctaggcaag atcatgtaca tttttggggg      780

ctacgagcag caggcggact gtttttccaa tgacattcac aagctagata ccagcaccat      840

gacatggact cttatctgta caaagggcag ccctgcacgc tggagggact tccactcagc      900

cacaatgctg ggaagtcaca tgtatgtctt tgggggccgt gccgaccgct ttgggccatt      960

ccattccaac aatgagattt actgcaaccg cattcgagtc tttgacacca gaactgaggc     1020

ttggctggac tgtcccccga ctccagtgct gcctgagggg cgccggagcc actcggcctt     1080

tggctacaat ggggagctgt acatctttgg tggttataat gcaaggctga accggcactt     1140

ccatgacctc tggaagttta atcctgtgtc ctttacctgg aaaaagattg aaccgaaggg     1200

gaaggggcca tgtccccgcc ggcgccagtg ctgctgtatt gttggtgaca agattgtcct     1260

ctttgggggt accagtccat ctcctgagga aggcctggga gatgaatttg accttataga     1320

tcattctgac ttacacattt tggactttag ccctagtctg aagactctgt gcaaactggc     1380

cgtgattcag tataacctag accagtcctg tttgcctcat gatatcaggt gggagctgaa     1440

tgccatgacc accaacagca atatcagtcg ccccatcgtc tcctcccatg ggtaggagga     1500

agtttctgcc acctcccctc ctgagcctgc tgtcatcttc actgcccctg cccatctgtc     1560

acccacctgc tcctttgacc cctggacttg gtatacctcc atgtggagtt gttgggcgag     1620

aggtgttctc tgtgctgtga attcagtggg gagctgtagc ggggtggggg ctaggttcct     1680

ccccccttgg gccgagggcc ccttcccctt ggtgctctgt ccccatccac ctcctttcag     1740

ctgctcctgg gcctcagctc tgcccagggc cagccaggtt ctgctgggaa gggaagggaa     1800

tggggagaag ggagaagcaa gcagtgtctg agcctcagga gcttccccct ccccctttgc     1860

ctatcccctc ccctctgctt gagccttgag ccttgactgg gagctgaaag gagttgcagc     1920

tgttggcatg agacctcctt ctccccgtct tggggaggtg gggaccagca gataaatccc     1980

acccttcctt gagctgtcgc tgtactctga agttcagcca gctcagattt tataaaaatt     2040

aattaaaatc tccaaacgtg                                                 2060


<210> 3133
<211> 3448
<212> DNA
<213> Homo sapiens

<400> 3133
ggccgggatt cgcggcccgg agctcgggac cggagtcagg aatggagaga agggtaatgg       60

ttttacctct tattgtggaa acctgttgag atcacagaga atatactgac ggcataaaag      120

ggcagaacca tagcagggtg cggttgcttc attccagcct cgcagtcacc tctgtgccct      180

gctggttgtc ttcccagcgc tgctgtagtt gccttccatg gatctatagg agagcaagtc      240

ctccaggagc tggtggtgtc tgtcgattga ctgagtgctg gagctggcag ccctgtgcag      300

gctgccacct ttgccccttt actgtgcttg ctcctgactc tatgtcgcgt ctccaaggag      360

aagaagtcct caccagtgaa cggagacctc tctgaactaa ggataccatg gccacgtcag      420

ccccactacg gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg      480

accctgtgac cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc      540

ccatctcagg gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca      600

tccgacccgt gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca      660

agggcaggca gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac      720

accgagagaa gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc      780

gggagtcccg ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc      840

acagggaaaa aatcctgaac cacctgagta ccctaaggag ggacagagac aaaattcagg      900

gcttccaggc aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga      960

ggcagtacat tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac     1020

acctgctgga acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca     1080

agagccgggg cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca     1140

aggcgcagca gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc     1200

cacggaagaa gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag     1260

aattctcaga taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc     1320

tgagagactt ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt     1380

acctgcagct gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct     1440

acctgcaccc ccagcagttt gactgtgagc ctggggtgct gggcagcaag ggcttcacct     1500

ggggcaaggt ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag     1560

agggggatga ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg     1620

atggatatga cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag     1680

aagaggagga ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact     1740

ctgtgaagag gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc     1800

tctcctcctc cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc     1860

ggccccggag agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg     1920

cagagtcaca ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct     1980

tcctgtggct caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg     2040

cccccagccc caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg     2100

gacgggatgc ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct     2160

ccccattgct gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa     2220

tggggctctt ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat     2280

gagggctcct ttcctttttg accacgacct tggccccagc tctgcactct ctggaataag     2340

ggcccgatgc agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac     2400

gcctaagatc attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct     2460

gctgcccacc ttccctggca ttttaaacag acctacccca ccccaactca gagttaagca     2520

tacatggcaa tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct     2580

ggagtaccag cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc     2640

agggctgagc atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt     2700

agggaaggat ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat     2760

tatctctaga ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat     2820

cagcacatcc aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg     2880

agttctgacc aggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc     2940

aggttccact ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga     3000

ggccacaagc ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc     3060

acggacccaa cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc     3120

tccagccaaa ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct     3180

gttcatccaa gttttaagtc ctccaccctg ttctaagaga ctgttccaac ggctctgggc     3240

ctcagtggtc acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct     3300

gcctgagtca cacgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga     3360

taacatctta tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta     3420

ggtgctcaat aaagacttgt tgaatgaa                                        3448


<210> 3134
<211> 740
<212> DNA
<213> Homo sapiens

<400> 3134
gggtttatta ctactgaagg aagaacgtga gtaggttagg atttcggttg agaggcttgg       60

ggtcttgcgt ttcgcccacc atctcctggg gacagggtgg agtcgatatc cgggacgggg      120

gggaggttgc ggtgcccctc agggctacct ctcaagagtg ctatcatttc cgcaggccag      180

atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac      240

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      300

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      360

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      420

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      480

ggccacagta gggaagaggc tggactatat cacagctgaa attaagcgat acgaatccca      540

gcttcgggat cttgagcggc agtcagagca acagagggag acccttgctc agctgcagca      600

ggagttccag cgggcccagg cagcaaaggc aggggctcct ggcaaggcct gaccccatgg      660

tggggggagg ggaggggagg ggagggaatg aggcagctct aggatctata ctgtagctaa      720

taaaatgtaa aaacacctgg                                                  740


<210> 3135
<211> 1893
<212> DNA
<213> Homo sapiens

<400> 3135
cagggagttg cctgagggaa aaggggcaga cgtccctggg ttccggtgtt cgcggaggag       60

tcgaggcacg gagaggcttc gggggaggga cggaaagaag ggtggcccgc caggcgggcg      120

gggtccatgg attcggggtg agggccgtcc gcggcctcgc tttcgcctcc tccgagccgg      180

gccggcgatg gccgcagctg tgaggcgagg tcgggtcccg tagcggcgcg cagcctcctt      240

gggggactcg gggtcctgca gaagaataga aggaaggtga taggatgtga tgatagaatt      300

tgtgatagcc aagcaacaac ttttcctaat tcggcatgtt aaaaaataag ggtcactcat      360

ctaagaaaga taacttggca gtcaatgcag ttgctttaca agatcacatt ttacatgatc      420

ttcaacttcg aaatctttca gttgcagatc attctaagac acaagtacaa aagaaagaga      480

acaaatctct aaaaagagat acaaaggcaa taatagatac tggacttaaa aaaactacac      540

agtgccccaa actagaagac tcagaaaaag aatatgttct tgatcccaaa ccgccgccgt      600

tgactttggc acagaagttg ggcctcattg ggcctccacc acctccactg tcatcagatg      660

aatgggagaa ggtgaaacag cgctctctcc tgcaagggga ctccgtgcaa ccatgcccca      720

tctgtaaaga agaattcgag cttcgtcctc aggtgctgct ttcatgctcc catgtgttcc      780

acaaagcatg tcttcaggct tttgaaaagt tcacaaataa gaaaacctgt cctctctgta      840

gaaagaacca gtatcaaacc cgagtgatac acgatggggc ccgcctgttc agaatcaagt      900

gtgtgaccag aatccaagcc tactggagag gatgtgttgt tagaaagtgg tacagaaacc      960

tgaggaaaac agtacctccc acagatgcca agttaagaaa aaaattcttt gaaaaaaagt     1020

tcacagaaat cagccaccgc atcctgtgct catacaacac caacattgaa gagctctttg     1080

cagaaatcga tcagtgcttg gccataaatc gaagtgttct tcagcagttg gaagaaaaat     1140

gtggccatga gatcacagaa gaggaatggg agaaaatcca agtgcaggct ctgcgccggg     1200

agacccacga gtgctccatc tgcctggccc ctctctccgc tgctggcggt cagcgcgtgg     1260

gtgcaggcag gcgttccaga gagatggccc tcctgtcctg ctcacatgtg ttccaccatg     1320

cgtgtctgct ggcactagag gagttctccg tgggagacag gcctcctttc catgcctgtc     1380

ctctctgccg ctcctgctac cagaagaaga ttcttgaatg ttgaattcat agtcaaggaa     1440

agttaggtaa ttctgaggaa aaaagtttac catcattttg gatgaactgc atgagttctg     1500

ggttaagtac tacaatgtaa tctgtttccc agggaaataa gctattggta gttgtaggaa     1560

atcttagtat attttaaaag ctgacatccc acctaatttt aatctttggt ctctaaaaag     1620

taaatttcaa atttatgagt ttaatcactt caaatatgaa tagcaaaaaa tgagagcttg     1680

cttacttcta aaaattgagg ttaagatata gctagtgtct gaacgacact ccttaaagta     1740

agttccaaat gtaaaacact ccttaagttc caaatgtttt ccgctaatag tctgtcctaa     1800

agcctttgcc attcctaata ctcgttttgt aataattgct gtatttctgt gtaataaaat     1860

ataaaaataa aatattcagt ggtattcaac atc                                  1893


<210> 3136
<211> 1943
<212> DNA
<213> Homo sapiens

<400> 3136
aggtaagagg aaactccatt ggataaatgg cgaggaaacg tatactccct cttaaggaac       60

acggtgtctt ccttcgtctc cgggttcccg agaccccaga gtcactgacc tccgtccctc      120

agctttcggg gttcggcagc agaaggggcg ggcccgggcc tgggattggc tggcgtcgtc      180

cgaccccctt cgctgctctc cattcgcaat cgcccgcggg cgcctgcgcg atgggtcggc      240

cgtggggagc ggggcgggaa gcgcttcagg gcagcggatc ccatgtcggc cctgaggcgc      300

tcgggctacg gccccagtga cggtccgtcc tacggccgct actacgggcc tgggggtgga      360

gatgtgccgg tacacccacc tccaccctta tatcctcttc gccctgaacc tccccagcct      420

cccatttcct ggcgggtgcg cgggggcggc ccggcggaga ccacctggct gggagaaggc      480

ggaggaggcg atggctacta tccctcggga ggcgcctggc cagagcctgg tcgagccgga      540

ggaagccacc agagtttgaa ttcttataca aatggagcgt atggtccaac atacccccca      600

ggccctgggg caaatactgc ctcatactca ggggcttatt atgcacctgg ttatactcag      660

accagttact ccacagaagt tccaagtact taccgttcat ctggcaacag cccaactcca      720

gtctctcgtt ggatctatcc ccagcaggac tgtcagactg aagcaccccc tcttaggggg      780

caggttccag gatatccgcc ttcacagaac cctggaatga ccctgcccca ttatccttat      840

ggagatggta atcgtagtgt tccacaatca ggaccgactg tacgaccaca agaagatgcg      900

tgggcttctc ctggtgctta tggaatgggt ggccgttatc cctggccttc atcagcgccc      960

tcagcaccac ccggcaatct ctacatgact gaaagtactt caccatggcc tagcagtggc     1020

tctccccagt cacccccttc acccccagtc cagcagccca aggattcttc atacccctat     1080

agccaatcag atcaaagcat gaaccggcac aactttcctt gcagtgtcca tcagtacgaa     1140

tcctcgggga cagtgaacaa tgatgattca gatcttttgg attcccaagt ccagtatagt     1200

gctgagcctc agctgtatgg taatgccacc agtgaccatc ccaacaatca agatcaaagt     1260

agcagtcttc ctgaagaatg tgtaccttca gatgaaagta ctcctccgag tattaaaaaa     1320

atcatacatg tgctggagaa ggtccagtat cttgaacaag aagtagaaga atttgtagga     1380

aaaaagacag acaaagcata ctggcttctg gaagaaatgc taaccaagga acttttggaa     1440

ctggattcag ttgaaactgg gggccaggac tctgtacggc aggccagaaa agaggctgtt     1500

tgtaagattc aggccatact ggaaaaatta gaaaaaaaag gattatgaaa ggatttagaa     1560

caaagtggaa gcctgttact aacttgacca aagaacactt gatttggtta attaccctct     1620

ttttgaaatg cctgttgatg acaagaagca atacattcca gctttccttt gattttatac     1680

ttgaaaaact ggcaaaggaa tggaagaata ttttagtcat gagttgtttt cagttttcag     1740

acgaatgaat gtaataggaa actatggagt taccaatatt gccaagtaga ctcactcctt     1800

aaaaaattta tggatatcta caagctgctt cttaccagca ggagggaaac acacttcaca     1860

caacaggctt atcagaaacc taccagatga aactggatat aatctgagac aaacaggatg     1920

tgttttttta aacatctgga tat                                             1943


<210> 3137
<211> 320
<212> DNA
<213> Homo sapiens

<400> 3137
acaatctccg ggaaggggca gagcagaagg tggtattcat cacaggacga gtccacccag       60

gggaaacacc ctcatcattt gtgtgccaag ggatcattga cttccttgta agccagcacc      120

ctattgcctg tgtcctccgg gaatacctgg tcttcaagat cgcaccaatg ctcaatcctg      180

atggagtcta cctgggcaat tacaggtgct tgtcattgat gaggaacggt tccagaggca      240

ggccattttt cccaagctcc tctgccagaa tgctgaggac ttctcctatt ccagcacatc      300

ctttaaccgg gacgctgtga                                                  320


<210> 3138
<211> 681
<212> DNA
<213> Homo sapiens

<400> 3138
tctgattttt gcttgcctgg tgcctggttt cccagcagtc atgtcatcca ggggcccttg       60

cacactggag acactcatca atcccagccc tagtgtagct gatgtaaaga tatatccaga      120

agaaatcact ccactcctac cagccatatc aggggagaag attgctgagg accaaacctg      180

cttttttctt caaatactgt tgaagtatat ggttattcag gctgcgagct tggagtggaa      240

gaataaggag aatcaagata ctggttttaa atttcttttt acattgtttc gaaagtatta      300

tcttcctcat ttatttccat catttactaa gttaacaaac atctacaaac ctgtacttga      360

catcccccat ttgagaccaa agcctgtgta cattactacc actcgagaca atgagaacat      420

ttacagtaca aagattccat atatggcagc tcgtgttgtt tttattaagt ggattgtaac      480

cttctttttg gaaaaaaagt atctaactgc aacacaaaac actaaaaatg gagttgatgt      540

attgcctaaa atcatccaga ctgttggtgg tggtgctgtg caggagagag cgcctgagct      600

ggatggtggt gggcccacgg agcaggacaa aagccattct aacagcagca ccttgtcgga      660

ccgaagactc agcaactcca g                                                681


<210> 3139
<211> 874
<212> DNA
<213> Homo sapiens

<400> 3139
acacggtatg ggtgtagact ggacccgccc cctaaatcca ggagaccatc aactatggaa       60

aggagatcta gggaacaccg tcttgaaccc gccaggggtt ttgagtctcg gacccaggag      120

atccaaccct gaccaccctc ccaggatgca gcagggggat gttaaatcag acttcaggaa      180

gaacttcctt gctgcctgag ttaggtgtcg tcacgcctgc ccaggggcca aggaggcggg      240

tttggtgcgg ccactccaag gccaaagcga gaaaatctta ctgcgcacgc gcaatagaca      300

gccgatggag ccaccgatgg agccgtccgg aggggagcaa gagcccggag ccgtcaggtt      360

cctggacctg ccctgggaag acgtgctgct cccacacgtc ctgaaccggg tcccgctgcg      420

ccagctgctc cggctgcagc gcgttagccg ggccttccgg tcgctggtgc agcttcacct      480

ggccgggctg cgtcgcttcg atgccgcgca ggtgggtccg cagatcccgc gggccgcatt      540

ggcccggctg ctgcgggatg ccgaggggct gcaggagctg gcactggcgc cgtgtcacga      600

atggctgtca gacgaggacc tggtgccggt gctggcgcgg aatccgcagc tgcggagtgt      660

ggcgttgggc ggctgcgggc aactgagtcg ccgggcgctt ggggctttgg ccgagggctg      720

cccacgcctg cagcgcctgt cgctcgcgca ctgtgactgg gtggacgggc tggcgctgcg      780

cggcctcgct gatcgctgcc cggccctgga ggagctggat ctcaccgcct gccgccagct      840

caaggacgag gccatcgtgt acctggcgca gagg                                  874


<210> 3140
<211> 1015
<212> DNA
<213> Homo sapiens

<400> 3140
gaagaagcag gcagcttgag acaggtggag ctggatcaag ctgtgaacgt gatttgctgg       60

aagctggtca ttagtgttga cgatgtgtca cactgtgtaa gggaatcgca tggagatggg      120

cattccgaac tgttaatggg gacatgggac tccagttgtc tctgatcact tgtgtggatt      180

ttcctggcgt agaacgacag aagccgctag taagtcgcca agacctacag caggaattct      240

gcaccaaagc ttaaaaaagt gaggaggaag taaatgctaa attattcatg agcctcattt      300

gacagcacat cagaagggga agtgtcaggg gttttataaa gggcataaaa tcttgttatt      360

ttaatttgca tctgggagaa tgtctgagca aggagacctg aatcaggcaa tagcagagga      420

aggagggact gagcaggaga cggccactcc agagaacggc attgttaaat cagaaagtct      480

ggatgaagag gagaaactgg aactgcagag gcggctggag gctcagaatc aagaaagaag      540

aaaatccaag tcaggagcag gaaaaggtaa actgactcgc agccttgctg tctgtgagga      600

atcttctgcc agaccaggag gtgaaagtct tcaggatcag actctctgaa aactgcaaat      660

ggaaaggaat tcaaaagaat ttagattaaa agttaaataa aaagtaggca cagtagtgct      720

gaattttcct caaaggctct cttttgataa ggctgaacca aatataatcc caagtatcct      780

ctctccttcc ttgttggaga tgtcttacct ctcagctccc caaaatgcac ttgcctataa      840

gaaacacaat tgctggttca tatgaaactt aggaaatagt gaataaggtg catttaactt      900

tggagaaata cttttatggc tttggtggag atttctcaat actgcaaaag ttgtccagaa      960

atgaatctga gctgatggtg actttaagtt aatattatta atatatcact gcata          1015


<210> 3141
<211> 577
<212> DNA
<213> Homo sapiens

<400> 3141
aatttttctc tgcttgttgg acatgaagag agggagacaa aggctctcag aaagagaaag       60

acgggctggt gaaggacaaa ctaaggaatt tgattattca cttttccaag ataaagtggc      120

atggagtggg gaaagaccat taaggaatgc tgaacataaa ggaatcctgg ggacctgacc      180

ctcagttaag acataagaat gacaaccagg agtgtgctcg atgttgaaac atttgtagca      240

gatatactga aaggagaaaa tttatccaag aaagcaaagg aaaagagaga atcccttatt      300

aagaagataa aagatgtaaa gtctatctat cttcaggaat ttcaagacaa aggtgatgca      360

gaagatgggg aagaatatga tgaccctttt gctgggcctc cagacactat ttcattagcc      420

tcagaacgat atgataaaga cgatgaagcc ccctctgatg gagcccagtt tcctccaatt      480

gcagcacaag accttccttt tgttctaaag gctggctacc ttgaaaaacg cagaaaagat      540

cacagctttc tgggatttga atggcagaaa cggtggt                               577


<210> 3142
<211> 834
<212> DNA
<213> Homo sapiens

<400> 3142
agatagaatc tgcagtgcct gaaatccagc ctgctgctta ctcacatcct catactcagc       60

tgcagactgc ctgacagaag ggctgccaaa ctgcactcca gacagacagg tgcacagcca      120

ggcctgattc agcaggaagc atctcagaca ccaaccacta tgctgtcagc agttgcccgg      180

ggctaccagg gctggtttca tccctgtgct aggctttctg tgaggatgag cagcaccggg      240

atagacagga agggcgtcct ggctaaccgg gtagccgtgg tcacggggtc caccagtggg      300

atcggctttg ccatcgcccg acgtctggcc cgggacgggg cccacgtggt catcagcagc      360

cggaagcagc agaacgtgga ccgggccatg gccaagctgc agggggaggg gctgagtgtg      420

gcgggcattg tgtgccacgt ggggaaggct gaggaccggg agcagctggt ggccaaggcc      480

ctggagcact gtgggggcgt cgacttcctg gtgtgcagcg caggggtcaa ccctctggta      540

gggagcactc tggggaccag tgagcagatc tgggacaaga tcctaagtgt gaacgtgaag      600

tccccagccc tgctgctgag ccagttgctg ccctacatgg agaacaggag gggtgctgtc      660

atcctggtct cttccattgc agcttataat ccagtagtgg cgctgggtgt ctacaatgtc      720

agcaagacag cgctgctggg tctcactaga acactggcat tggagctggc ccccaaggac      780

atccgggtaa actgcgtggt tccaggaatt atcaaaactg acttcagcaa agtg            834


<210> 3143
<211> 9618
<212> DNA
<213> Homo sapiens

<400> 3143
ggcaacagca atgacatccg cgtggctggc acaggggaca ggcgagggcg tgaacgatgt       60

gcggaaggga gcctgtgcca gccacgtcag caccatggcc agcttcctga agggggccca      120

tgtgaccatc aacgcacggg ccgaggagga tgtggagcct gagtgcatca tggagaaggt      180

ggccaaggct tcaggtgcca actacagctt tcacaaggag agtggccgct tccaggacgt      240

gggaccccag gccccagtgg gctctgtgta ccagaagacc aatgccgtgt ctgagattaa      300

aagggttggt aaagacagct tctgggccaa agcagagaag gaggaggaga accgtcggct      360

ggaggaaaag cggcgggccg aggaggcaca gcggcagctg gagcaggagc gccgggagcg      420

tgagctgcgt gaggctgcac gccgggagca gcgctatcag gagcagggtg gcgaggccag      480

cccccagagg acgtgggagc agcagcaaga agtggtttca aggaaccgaa atgagcagga      540

gtctgccgtg cacccgaggg agattttcaa gcagaaggag agggccatgt ccaccacctc      600

catctccagt cctcagcctg gcaagctgag gagccccttc ctgcagaagc agctcaccca      660

accagagacc cactttggca gagagccagc tgctgccatc tcaaggccca gggcagatct      720

ccctgctgag gagccggcgc ccagcactcc tccatgtctg gtgcaggcag aagaggaggc      780

tgtgtatgag gaacctccag agcaggagac cttctacgag cagcccccac tggtgcagca      840

gcaaggtgct ggctctgagc acattgacca ccacattcag ggccaggggc tcagtgggca      900

agggctctgt gcccgtgccc tgtacgacta ccaggcagcc gacgacacag agatctcctt      960

tgaccccgag aacctcatca cgggcatcga ggtgatcgac gaaggctggt ggcgtggcta     1020

tgggccggat ggccattttg gcatgttccc tgccaactac gtggagctca ttgagtgagg     1080

ctgagggcac atcttgccct tcccctctca gacatggctt ccttattgct ggaagaggag     1140

gcctgggagt tgacattcag cactcttcca ggaataggac ccccagtgag gatgaggcct     1200

cagggctccc tccggcttgg cagactcagc ctgtcacccc aaatgcagca atggcctggt     1260

gattcccaca catccttcct gcatcccccg accctcccag acagcttggc tcttgcccct     1320

gacaggatac tgagccaagc cctgcctgtg gccaagccct gagtggccac tgccaagctg     1380

cggggaaggg tcctgagcag gggcatctgg gaggctctgg ctgccttctg catttatttg     1440

ccttttttct ttttctcttg cttctaaggg gtggtggcca ccactgttta gaatgaccct     1500

tgggaacagt gaacgtagag aattgttttt agcagagttt gtgaccaaag tcagagtgga     1560

tcatggtggt ttggcagcag ggaatttgtc ttgttggagc ctgctctgtg ctccccactc     1620

catttctctg tccctctgcc tgggctatgg gaagtgggga tgcagatggc caagctccca     1680

ccctgggtat tcaaaaacgg cagacacaac atgttcctcc acgcggctca ctcgatgcct     1740

gcaggcccca gtgtgtgcct caactgattc tgacttcagg aaaagtaaca cagagtggcc     1800

ttggcctgtt gtcttcccct attttctgtc ccagctcatc cgtgtctctg aagaacaaat     1860

atgcttttgg accacgaatt cccagtttgg tctacacagg ctcgcagctc tcacctgtcc     1920

tgctgtagcc tgaatgctcc catgtgggaa tagcacccca ccacctgccc agtgtctgcc     1980

tctgctccgt gtctggggtg agcaccctca ccctgagact gtggctgatg atgatcagcc     2040

accaggaaga ggctaaatgt taagatggga ctgaagttgg agccttcctg cgttccagtt     2100

cctctaggag aggccaaggg ctgccctgct cccagcttca gggagcctct gcctacatgg     2160

gatggcccac tgtgtggcgt caggtacctg gcacccactg agcatccggg gaattaggtc     2220

cctcctgtgc cccagagctg ctaggcagac tgctaggcgg ttgactcaag gtgttacctg     2280

ctagtgcctg gggtgaaggc tgcatggagc ccaaccttgc tcctggcctt cctgtgctca     2340

ggcctctccc cttttcgcca gggcttcctg gtgcctctcc catgaagagg gaacttcccc     2400

tccactccca tggaagaccc aggtttgggc tgttgccagc tttgaggccc cctgtgggct     2460

tgcctgtccc aacccaagag gcagggctca aagtgccacc cgggggttgc aaggacagca     2520

gaggaccacc tgccctctgc aggaagctgt ccaggaagcc gtgtcctggg ctgtggtcct     2580

tgctccccat ggggagagct gggtcacttg gcctcttcta actggcccca agcacgccaa     2640

ttctggagca tggttactaa gtggctctga agcttcaggg tcaccacagg cttgtcctga     2700

ctgcaaactc atggagtggt tgcagccctg gctcagtgtc ctgatgacta ggtgtgggta     2760

ctaggctcct gcccctggtg acacacgtat ggagtggggg agggtgggtg gctgcacccc     2820

tggttctgga gtccccacag ctgatggcgg tgtgagcctg gcatgcacgg ctgcgctgga     2880

ctccaggctg ttgggggagg tgcctttatt gcccaagccc acccctcact tggccttgcc     2940

ctgggcagcc acagcctcca tggccttccg caccgtttcc tcatcaccca ggaactgcat     3000

gggcttggtg ggcttcagct ccttgttcag ctcatacaca atggggatcc ccgtgggcag     3060

gttcagctcc atgatcgcct ggtctgacat ccctatgccg gaaggaatag gtgtccttag     3120

cccctctgtc cccagcctgt ttacacagca gacactatgt gacctttatg gtccacagag     3180

ccagttcccc tggcaccaat tccttcccag ccctgagaac gaggccacag aaatgttgcc     3240

aaaggtcaag gagtaactga gttagaccaa gcagcctaca gaaatagccc agtggtgaaa     3300

aaaatgggga cttcagcccc acccaagtgg ctgtgatctg tggtggtgct gtccatagtt     3360

ccctcagccc agtgtgactc cagccagact gaagttgagg gtcaggaagg gacactcacc     3420

ctttgttttt tttttttctt ttctttttct ttttcttttt tttgagatgg agttttactc     3480

ctcttgccca ggctggagtg cagtggcacg atcttggctc actgcaacct ccatctcctg     3540

ggttgaagtg attctgcctc agcctcccaa gtagctggga ttacaggtga gcgccaccac     3600

acccggctaa ttttgtattt ttagtagaaa cgggttttac catgttggtc aggctggtct     3660

caaactcctg acctcaggtg atctgcctgc ctcagcctcc caaagtgctg ggattacagg     3720

agtgagccac cgtgcccagc accctttggt ttctaaagtg ctctaaattc tagacatcct     3780

gaacagagga gcaagtgcgg aatggagctg gaggagggac agggaggccg agcctggtcg     3840

aaacctgacc ctgcctgcct cctgcagccc ctgagctggg aatagcagct cgacctttga     3900

tgttcgcgcc actccacccc tgctccgtgc aggagggttt aagaaaatgt tctctgggga     3960

gtcagagtga aatccctcat attcaccacc aaaagtgcgt cccctttccc caaaccaggc     4020

tgtgggaggg tcatggggct gcatgaagtc tccggaaggg agaggaggca ggtggtcctt     4080

ccctctgcct ggccccagtg ccaggtgcca ggtgtccgtg tttggagcgg gcaggcttgg     4140

ggctggctgg gtctccgggg cctgccggtc tgggtgctct ggccaactgc ccaacggccc     4200

taggagcagg aggtctgggg cacacccttc tagcctttcc aggactcaac aagctttaag     4260

gtcattcaga tgctaattta gactgccctt gtgtcagaat actaaggtgg gaggcggagc     4320

ggaggtgcca gtcactctgg gcgaggcctt actgcgccca tgcatcccgg gcccatttgt     4380

cagcccttgc tcttcagtgg gagcccagct gcaagcccag agtctggcca ctccatagtc     4440

ctgcacccct cttttgattg gtctttcctt tgcccagaga ggggctccag agggagatag     4500

gtggtgaagc tcatgcaggg attctgagga cctgatgggg gagggccctg cgaggggtcc     4560

aagcctacat caagaggaat tcagtaccag ggggagctcc ccaccacccc ggaaaaggga     4620

gaggcccaga gatggaggtg gcttgtccag ggccccacag taagttggga tttggagcca     4680

gatgctctaa gcccagccct tccgtttcct agctgggtgt cccttggcag atgccacctt     4740

tggagcctgc cccacctcgg gacacagcga gcttcgagtg cagtcagccc ctgtggagtg     4800

tgtcccagtt acacagaaat ggggaaaatt tcacaaaact aaaaaatggc ttctcagccc     4860

tcctttttca gtgaatgatg tggagcccca cgcctagaaa gcctggtcca tgggcgagag     4920

actttgctga gatgagaagc cagctggggc tgctgcccac ccaccctgcc caggctcctg     4980

aaggtggcct caccttccag gtgcttgaca atgccccgca ggctgttccc gtgggctgca     5040

atgagcactc gcttgccggc cttgatctgg ggaacaatct cctcgttcca gaagggcagg     5100

gcccgggcaa tggtgtcctt gaggctctcg caggtgggga gttccccggg cttcaggcct     5160

gcgtaccgac gctcctgggg gacacaggca cgctgctttc cctcccaagc cagtgggccc     5220

ccacccgact ccccactctg cagcttccca gaggccttcc cagcaaaggc agcccacctt     5280

gctaatggag ttgtagtagg ggtgcttctc gtccatcggg ggcggcggga tgtcgaagga     5340

gcgcctccag atcttcacct gctcctcccc gtgcttggcg gccgtttctg ccttgttgag     5400

gcctgtgagg cccccgtaat gccgctcatt gaggcgccaa gtgcgcacca caggcagcca     5460

catctggtcc gtgccgtcca ggatggccca gagggtgcgg atggcccgct tcagcactga     5520

cgtgtagcag atgtcaaact ccatcttggc atccttgatg gccttggctc cccgcttggc     5580

ctcctcggtc cccttttcac tcagctctgc atcgaaccag ccacagaaac ggttctcctg     5640

gttccatgtg ctctcgccgt gccggaccat cacgaggcgg tgagtggcca tggtggcagc     5700

agggaccaca gaggactctg gacggggacg gctgcttccc aacactccca gctttataat     5760

agtgtcttcc cagcccccac ccaccccagc caactgccaa tcagcattcc aggcggtggc     5820

aggtgaccag tagctgagct gctgggggct gggggccagg ggagtgtgca ggccaagagg     5880

ctgtgcttaa aatagcccca cgcatccacc agctcctggc ctgggttcag gtggcatgtc     5940

tataaccagc tggcacccag agcccagact gagtggggct gctggtcagg gatgggcgtg     6000

aagggcagaa gtctgggcca ggggagatgg ggatagcagg gacagagggg ctctccaggg     6060

caacgctcag tggcctatca gccattctct gctcagacag aggcacaaac aaaatcccaa     6120

cccctttctc ctgtgattgg cagccaggct aggaggcggc cctcagcagg cagaggagga     6180

gagccagagg agctggtgca gaccacagct ttgtggagag gagtctggcc ttgtggaagg     6240

taccaggcag cagcagcaga atgggcaagg gctggggctg agccgggttt ccaggacaaa     6300

gggggaaagg gcccctgtct ttcctccggg gtccctttgt caaggtctca tccatacatg     6360

ccccatgctc ccaccctatc tgccctcacc caagccacgc tcactctcct agccgaaacc     6420

accttgaaaa agagaaatcc aagggggttt gggggcagga ctgaggactg tcagaagtct     6480

tgattgttag gtaaatgctc agcttagcag gaacccacaa cgtaggctga agggtggcac     6540

ggagttgagt ctaggaccaa gacttctgca ttcaggtttg ggggatgaga gccaccaagg     6600

cagggaagag actatgagca ataaagtcac aattggggcc ctaatgaagg ggccatggcc     6660

agacccttgg gcatgggccc catccagggc ctcccatttc ctcccacccc agtgaccaca     6720

ctgtcacctg cgacacttct gataacagga gcgggtaggt gagaggccag cagagggacc     6780

accactctga gacttggatc tgagtgtgca agaaaccctc gacaggcctc cctccatccc     6840

tgctggccta cctggggagg ggctcctggc ttggggcctg tgaagctaag gctctgtacc     6900

caaaggttgg cagacaagtc ccagtgggca aagtcctgtc ggctgccagg acccccaagg     6960

ctggcaggtg gaacccatcc ctcctagcag tgccatgcgc aggtctcact gttccacact     7020

gatcctgatt gaagccacat ctcctcatct gcttttgtcc ctttgaccaa gagttgattc     7080

actagcccaa ctaaacatga ctgaggacca ggctctggca gtcccacagg ggccagacat     7140

gaagcccata tttcagtgga ggagggatcg taccagcagc taaacatgcc taccgtagat     7200

agcaccagat gctaggaagg aaggaccata atgtactggg agagatggga aaggagaggc     7260

cggggacagc cctgaggtga catgtgagtg gaaagagcgg agtgcaaagg cctcagctat     7320

gatgagtcct acagggagag caattcaggt agaggggttg gcaaagaccc aagccctaca     7380

gaaagcaaac aagctggggc agcgaccatc aggggcacat ggcagagagg tgggctttgt     7440

gtcccaacac agtgggaatc actggagact ttgaagcatg gtcatatttt caagtcactt     7500

gcagctgtgt aggagtggaa gtagaagctg agtaccctgc aggtctcggc agctttgatg     7560

agaacaaggc cgcttagcca gggctgggtg cagaagcagt ggcaaggatc ccccagacct     7620

gggagacctc actgccaacc aagcaggagg tgtcaaaaag gaaaggggag cccaaagaag     7680

ggctggactt cggggaagca agcccctgct tctgaccctt ggctccggct tgactttcct     7740

ttgattcatt tgacaagtag ttgctggcct ctgcagtgtg ccagagcttt cttggagggg     7800

tacaggggta ggaaaaccaa aagccaccct cagggcctcc atccaggaag gcatagcatg     7860

gtgggcggcg aggaaggctg ctgagtcaac aaggtggtcc caggaaggtg gagggagcat     7920

cttcccatgt ctctcccact gacagccacc aatcctggac agatgcagga gcagctgtca     7980

gtagacagat aagaaaagga gatcagattc aaagttccgc agagaagtgg tgaggtaaca     8040

agtattgcct agcctggaca cacaggcggc ttgaaacctc aagtgcacca acagaaagag     8100

ctccaggaag aatcagagga gtgggatgtg aagcccctcg aagtcagtga gttgggggaa     8160

tccctccaat ttttcttttc ttctctaccc cagctcctgg gcagtaacat ggaggtggca     8220

gtggtggcac agtgacggta gtgtgagctg ggtacgcact tgaaacctga gagggtaacg     8280

ctaccctctg tctagaggag ccatggcccc aaaagcatgg ggcaaccacc ttctgcagct     8340

cctttctgcc cccctgcgct gggccctgga tgcagtttca gggagtatgc agcagggtag     8400

gtagggaaag agccccagat ttgtggctgg aggtcttggt agggatgttg cagggagctg     8460

ttgtgtttca gggagagtac agagaaggga gagatgaagt gagtgatccg ataaagtgat     8520

atgtgaagtc attggcttgc tgccaagctg cgcacagggc tgaccctaga tgcacattgc     8580

aggtcccaga ctgaccggtg tagatacagg actaatatga ctagtagtgc aaacacttta     8640

aacagtcaac attctgctta ggatttaaac aaggtccaga gtctcaacat aatatttaaa     8700

atatccaggt tatccaaaat aacccagtgt atgaaaacca ggaaaatctt aacatgggag     8760

aaaagaagat gatcaataca tgcccatcct gagatgattc aactattgga atgatcagat     8820

acagacttca aagcagctat ttataaccag ccttcagaaa gtattggtga atattcttaa     8880

acagaatgga aatgacaaag catggagtcc ataaattaga tgatagtttg gaaaaagata     8940

taaacttaca aaccaagaag ctcagtgaac cacacaactg gataaattaa caacaaaagt     9000

ccaagcttag acacatcata aagaaacttc tgaaaactaa agaccaagaa aaataagatc     9060

agccagagaa aaacgataca tttcattcag gtgaacaatt ctttgaaaga ctggatcttc     9120

accagaaact atagaggcca gaaagaagtg gaacattttt agttttgaaa taactgtcac     9180

ccaagaattc tatatccagt aaaaatttct attttactgg aataaaagaa tgaaataaag     9240

acattctcaa atgaaggcaa gctgaggaaa ttcataacca aagaatctgc tttaaaaaaa     9300

tgttaaacca agttcttcag acagaagaga ttactggggg caattcaaaa ctttgggaat     9360

gcaggaagaa catcataaat ggcaaaagtc cacataaata tgaaactatt ctttacttct     9420

ttaagagtta tgtgatggtt gaattaagtc atgatactgt ctgatggagg cttcagtgta     9480

tacagatgta agacaactag aacatgaggg gagaagggtg aagggaccta gatggtagtg     9540

aggtttctac atgctacttg aaatggcaaa acattaatct aaattgactg taagagtatg     9600

tgtatttggc cgggcagg                                                   9618


<210> 3144
<211> 1476
<212> DNA
<213> Homo sapiens

<400> 3144
gaaagagcag aagaggaggt ggggtggagg gagcagagcc agggattagg ggactactga       60

ggctctggag atgagaccgc caggagtcct tccccaccat gagccccctc cactcctgca      120

gctggaggag tttttcccag tctcagtgct gccctggggc gagagagact gaacaagctg      180

tttgggtggg aagagaatgg aggaagttga cagggatggg cggggcccgt gggggggctg      240

accaggaacc cagcttcctg ctcagtaccc aggcatccag cccccagctc acccccaccc      300

cttccagccc ccactcccct caggaaccca aggttccagc cctcctccca aatcccagcc      360

acccctcccc caccagtttc tcccctctag gggatggagg ctgagagacc ccaggaagaa      420

gaggatggtg agcagggccc ccctcaggat gaggaaggct ggccccctcc aaactccacc      480

actcggcctt ggcgatctgc tcctccatcc cctcctcctc cagggacccg ccacacagcc      540

ctgggacccc gctcggcctc cctgctctcc ctgcagactg aactccttct ggacctggtg      600

gctgaagccc agtcccgccg cctggaggag cagagggcca ccttctacac cccccaaaac      660

ccctcaagcc tagcccctgc cccactccgt cctctcgagg acagagaaca gctttacagc      720

actatcctca gtcaccagtg ccagcggatg gaagcccagc ggtcagagcc tcccctccct      780

ccaggggggc aagagctcct ggagttgctg ctgagagttc agggtggggg tcgaatggag      840

gagcaaaggt cccggccccc cacacacacc tgctgagact tgagccccaa ccagcccttc      900

cttgccactg gtctcaaagc tgggcagccc attgcatgcc ctcaactctt gcttggcagg      960

ggtaccagag actgaaagac acggcacaaa tctcaatatt catctcccac atcaccttcc     1020

ctgggaactg gacagggtga aagtcctcaa actctgggaa caggcgagat ggaacaggga     1080

tttaactccc cgcccacagg tccatgggag cttgaggcag taagggggat cccaggcacc     1140

catctcaagg agtggctggg agtcttttcc ctaacttgtg gggacaccac cagttgtcaa     1200

gctactaggc agtagggtct gagggctcag gcctccacct gagaggttat aacctgagag     1260

acagctctac ccttcctccc agtaagaagg gaaggtgggt gggcacctga gagattaaga     1320

ctattctccc agtcccacta ccagcacccc cgatccctga gactgagggg tttacgggct     1380

gtgaatggac cttcagccct gcccaccctc cctccccact gctgctgagt ctgtctgatg     1440

ttttggttgt gtgaataaat ataattcccc tctgga                               1476


<210> 3145
<211> 2892
<212> DNA
<213> Homo sapiens

<400> 3145
tttgttcgcc tctcttcggc cctctactca agagctccgt ctccgtctcg ccctcctcga       60

agtcctcgtc gcgcgcccgc gacccaggtc gccctgaaat ctagcccgtc cgagcgcgag      120

tccaacgccg cggccgcacc aaggccccct cagaccgtgc catgggtgac agtgatgacg      180

agtacgatcg aaggcgcagg gacaagttca gaagagagcg cagcgactac gaccgttccc      240

gcgagagaga tgaaagacgt cgaggggacg attggaatga cagagagtgg gaccgtggcc      300

gtgagcgccg tagtcggggt gaatatcggg actatgaccg gaatcggcga gagcgcttct      360

cgccacctcg ccacgaactc agcccgccac agaagcgcat gaggagagac tgggatgagc      420

acagctctga cccataccac agtggctatg agatgcccta tgctgggggg ggtgggggcc      480

caacttatgg cccccctcag ccctggggcc accctgacgt ccacatcatg cagcaccatg      540

tcctgcctat ccaggccagg ctgggcagca ttgcagagat tgacctgggt gtgccgccgc      600

ccgtgatgaa gaccttcaag gagtttctcc tctccctgga tgactcggtg gatgagacgg      660

aggccgtcaa gcgctataat gactacaagc tggatttccg gaggcaacag atgcaggatt      720

tcttcctggc gcacaaagat gaggagtggt ttcggtctaa gtaccaccca gatgaggtgg      780

ggaagcgtcg gcaggaggcc cggggggccc tgcaaaaccg actgagggtc ttcctgtccc      840

tcatggagac tggctggttt gataaccttc tcctggacat agacaaagct gatgccattg      900

tcaagatgct ggatgcagcc gtgattaaga tggaaggagg cacggagaat gatcttcgca      960

tcctggagca ggaggaggag gaggagcagg caggaaagcc tggggagccc agcaagaaag     1020

aagaaggacg ggctggagca ggcctagggg acggggagcg caaaaccaac gacaaggatg     1080

agaagaagga agacggcaag caggctgaga atgacagttc taatgatgac aaaacaaaga     1140

agtcggaggg tgatggggac aaggaagaga agaaagaaga ctccgagaag gaagccaaaa     1200

agagtagcaa gaagcggaac cggaagcaca gtggtgacga cagctttgac gagggcagcg     1260

tgtcagagtc tgagtcggag tcagagagcg gccaggctga ggaggagaag gaggaggccg     1320

aagcgctcaa ggagaaggag aagcccaagg aagaagaatg ggagaagccc aaggacgccg     1380

cggggctgga gtgcaagccg cggccgctgc ataagacctg ctccctcttc atgcgcaaca     1440

tcgcgcccaa catctcccgg gccgagatca tctccctttg taaaaggtac ccaggcttta     1500

tgcgggtggc gctctcagag ccccagccag agaggaggtt tttccgtcgt ggctgggtga     1560

ccttcgaccg cagtgttaac attaaagaga tctgttggaa cctgcagaac atccgtctcc     1620

gggagtgtga gctgagccct ggtgtgaaca gggacctgac ccggcgcgtt cgcaacatca     1680

acggcatcac ccagcacaag cagattgtgc gcaacgacat caagctggcg gccaagctga     1740

tccacacgct ggatgacagg acacagcttt gggcctcaga accagggacg cctcccctgc     1800

ccacgagcct gccctcgcaa aacccgatct tgaagaatat caccgactac ctgatcgagg     1860

aagtaagcgc cgaggaggag gagctgctgg ggagcagcgg gggcgctcct cctgaggagc     1920

ctcctaagga agggaacccg gcagagatca acgtggagcg ggatgagaag ttgattaagg     1980

tcttggacaa gctcctcctt tacctgcgca tcgtgcattc cttggattat tacaacacct     2040

gtgagtaccc caacgaggac gagatgccca atcgctgtgg gatcatccac gttcgggggc     2100

ccatgccacc caaccgcatc agtcacgggg aagtgctgga gtggcagaag acttttgagg     2160

agaagctcac gccgttgctg agtgtgcggg agtcactctc agaggaagag gcccagaaga     2220

tggggcgcaa agacccagag caggaagtgg agaagttcgt cacctccaac acgcaggaac     2280

tgggcaagga taagtggctg tgtcctctca gtggcaagaa attcaagggt cctgagtttg     2340

tgcgcaaaca tatcttcaac aagcatgcag agaaaattga ggaagtgaaa aaggaagtcg     2400

cgttttttaa caacttcctc actgatgcta agcgcccagc tctgcctgag atcaagccag     2460

cccagccacc tggccccgcc cagagtttga ccccaggact cccctaccca caccagactc     2520

cccagggcct gatgccctat ggtcagcccc ggcccccgat cttgggctat ggagctggtg     2580

ctgtccgccc tgcagtcccc acaggaggcc ctccataccc ccatgccccg tatggtgctg     2640

gtcgagggaa ctatgatgcc ttccgaggcc agggaggtta tcctgggaaa cctcgcaaca     2700

ggatggttcg tggagaccca agggccattg tggaatatcg ggacctggat gccccagacg     2760

atgttgattt cttttgagcc gtcccccgtt cctcagtcct gtatcatcca tacttgtact     2820

accttgtcct atgaagctct gagaattttt tgtacgatca gccttactgc taataaaagc     2880

acttccacag gg                                                         2892


<210> 3146
<211> 3626
<212> DNA
<213> Homo sapiens

<400> 3146
acggcgcgag tccgagggcg acagcagcgc gcaggcgcac gtcagtcccc gcgcttttcg       60

gaggctgcca gcgtcccaca ccagccgcag gtgaaaaccg gcagaaagac attaagagat      120

tttcctgcag tcactgctgg cagatgatag agccaggatt tgaaagcagg cagcctggct      180

ccagaccctg tgctcttaac tcccgttttg catcaagaac agaatcctat gaaaggcttg      240

cacagtgctt ggtactgagt aggcactccg tcagtatttt agtagctatt attccaaagg      300

acactgtatt ctaggtacta agacaatgtg aatggaatgg aaaacaattc ctccctgcag      360

aagccaactg tctaggaaga cagataatga cattattaaa ataatcagaa cattggcaaa      420

ataaagaaga ttgaaatgca gttcatatga cagtgctaat taatcatact ttttagatct      480

aggaaaggcc ataaaggtta aattgacttg gaaatggtaa acaagacaat ggttgtgtca      540

ctgatcggtg atggccagtt tttggttatc cttatttgcc atttaaatga ttgaattgaa      600

aggaagaagt aagacttgga agatgaatat tgaaggaaag gtgaagatgg aaaagagaag      660

ggggtttatt ctgagaacag tgactagaac tctgaggata gcagcatcaa ggagcattgt      720

gtacatgcag aagtgcacag tacctggagt gaaactgctt gtgttcgatt tctgatacca      780

ttcataactg gctgtgtgat ctcaaaacct ctaaaatgca gacctccagc tctagatctg      840

tgcacctgag tgaatggcag aagaattact tcgcaattac atctggcata tgtaccggac      900

cgaaggcaga tgcataccgt gcacagatat tacgcattca gtatgcatgg gcaaactctg      960

agatttccca ggtctgtgct accaaactgt tcaaaaaata tgcagagaaa tattctgcaa     1020

ttattgattc tgacaatgtt gaatctgggt tgaataatta tgcagaaaac attttaactt     1080

tggcaggatc tcaacaaaca gatagtgaca agtggcagtc tggattgtca ataaataatg     1140

ttttcaaaat gagtagtgta cagaagatga tgcaagctgg caaaaaattc aaagactctc     1200

tgttggaacc tgctcttgca tcagtggtaa tccataagga ggccactgtc tttgatcttc     1260

ctaaatttag tgtttgtggt agttctcaag agagtgactc attacctaac tcagctcatg     1320

atcgagaccg gacccaagac ttcccggaga gcaatcgttt gaaactcctt cagaatgccc     1380

agccacctat ggtgactaac actgctagga cttgtcctac attctcagca cctgtaggtg     1440

agtcagctac tgcaaaattc catgtcacac cattgtttgg aaatgtcaaa aaggaaaatc     1500

acagctctgc aaaagaaaac ataggactta atgtgttctt atctaaccag tcttgttttc     1560

ctgctgcctg tgaaaatcca cagaggaagt ctttttatgg ttctggcacc attgatgcac     1620

tttccaatcc aatactgaat aaggcttgta gtaaaacaga agataatggc ccaaaggagg     1680

atagcagcct gcctacattt aaaactgcaa aagaacaatt atgggtagat cagcaaaaaa     1740

agtaccacca acctcagcgt gcatcagggt cttcatatgg tggtgtaaaa aagtctctag     1800

gagctagtag atcccgaggg atacttggaa agtttgttcc tcctataccc aagcaagatg     1860

ggggagagca gaatggagga atgcaatgta agccttatgg ggcaggacct acagaaccag     1920

cacatccagt tgatgagcgt ctgaagaact tggagccaaa gatgattgaa cttattatga     1980

atgagattat ggatcatgga cctccagtaa attgggaaga tattgcagga gtagaatttg     2040

ctaaagccac cataaaggaa atagttgtgt ggcccatgtt gaggccagac atctttactg     2100

gtttaagggg accccctaaa ggaattttgc tctttggtcc tcctgggact ggtaaaactc     2160

taattggcaa gtgcattgct agtcagtctg gggcaacatt ctttagcatc tctgcttcat     2220

ccttaacttc taaatgggta ggtgaggggg agaaaatggt ccgtgcattg tttgctgttg     2280

caaggtgtca gcaaccagct gtgatattta ttgacgaaat tgattccttg ttatctcaac     2340

ggggagatgg tgagcatgaa tcttctagaa ggataaaaac agaattttta gttcaattag     2400

atggagcaac aacatcttct gaagatcgta tcctagtggt gggagcaaca aatcggccac     2460

aagaaattga tgaggctgcc cggagaagat tggtgaaaag gctttatatt cccctcccag     2520

aagcttcagc caggaaacag atagtaatta atctaatgtc caaagagcag tgttgcctca     2580

gtgaagaaga aattgaacag attgtacagc agtctgatgc gttttcagga gcagacatga     2640

cacagctttg cagggaggct tctcttggtc ctattcgcag tttacaaact gctgacattg     2700

ctaccataac accggatcaa gttcgaccca tagcttacat tgattttgaa aatgctttta     2760

gaactgtgcg acctagtgtt tctccaaaag atttagagct ttatgaaaac tggaacaaaa     2820

cttttggttg tggaaagtaa gtgggatact tggaatcaag gcatctctgt agtacagtct     2880

tctttatttt ttagcataga aagttgggga tgtgttaatt gtatttttaa gaatatattc     2940

taagttctgt acttcaaata atagcacaga ttttacatct gattgacata gtgtatgtta     3000

atgtaagttt tgctttccag tgattacctg atacgtaagc ctatttgaac aaagtgagaa     3060

tgaacttttg tttctaagaa gtctttatct tgaagctata taacatgaaa agtgagctca     3120

aatttttttt agttgaagat tacatataaa gttgtgtctg attaatattc atcttttatt     3180

gaagaaagtg ccttctgatg gccacataat tcttaatgtc agctagtata atggtttaca     3240

tttggacaaa gtattgctta gtgttattta agtagattta agatctcaaa gctaaagtgc     3300

caatttttac tttcttcagc caatttgtta cctcttttat ggtttttaat ttttatcagg     3360

actaacattt tcagaaatag caaggtgtga tctagtatta gattcacaga actgaaaggt     3420

taattaagaa tgttggttat tttcacggga gcgtgtgata tttaacatta atattttatt     3480

tgacactaca gcctgtaata ctgctctctt tcaaaaacaa gttttcagat ttttataaca     3540

gacccatttt gttttatgaa acatgttcat tacagaaaca tgagaaaata gagataagta     3600

aaaagaataa aagtcactat tatcct                                          3626


<210> 3147
<211> 1644
<212> DNA
<213> Homo sapiens

<400> 3147
tcacttcctc ccgaagacgc tgtttcctag caaccgccct ccgcctctgt tattagcccc       60

tcctcctcgc tcggtccagg accggctctg cgggcgccgc caggcccaga ccaagctact      120

atcagaagtt gaattctaat aattagctat tttataaagg taacgagaaa aaatacacta      180

tgtctgatga agtttttagc accactttgg catatacaaa gagtccaaaa gttaccaaaa      240

gaactacttt ccaggatgag ctaataagag caattacagc tcgctcagcc agacaaagga      300

gttctgaata ctcagatgac tttgacagtg atgagattgt ttctttaggt gatttttctg      360

acacttcagc agatgaaaat tcagttaata aaaaaatgaa tgactttcat atatcagatg      420

atgaagaaaa gaatccttca aaactattgt ttttgaaaac caataaatca aacggtaaca      480

taaccaaaga tgagccagtg tgtgccatca aaaatgaaga ggaaatggca cctgatgggt      540

gtgaagacat tgttgtaaaa tctttctctg aatctcaaaa taaggatgag gaatttgaaa      600

aagacaaaat aaaaatgaaa cctaaaccca gaattctttc aattaaaagc acatcttcag      660

aaaacaacag ccttgacaca gatgatcact ttaaaccatc acctcggcca aggagtatgt      720

tgaaaaagaa aagtcacatg gaggagaagg atggactaga agataaagaa actgccctca      780

gtgaagaatt ggagttacat tctgcacctt cttcccttcc aacgccgaat ggcatacaat      840

tagaagctga gaaaaaagca ttctctgaaa accttgatcc tgaggattca tgcttaacaa      900

gtctagcatc atcatcactt aaacaaattc ttggagattc tttttcacca ggatctgagg      960

gaaacgcatc tggaaaagat ccaaatgaag aaatcactga aaaccataat tccttgaaat     1020

cagatgaaaa taaagagaat tcattttcag cagaccatgt gactactgca gttgagaaat     1080

ccaaggaaag tcaagtgact gctgatgacc ttgaagaaga aaaggcaaaa gcggaactga     1140

ttatggatga tgacagaaca gttgatccac tactatctaa atctcagagt atcttaatat     1200

ctaccagtgc aacagcatct tcaaagaaaa caattgaaga tagaaatata aagaataaaa     1260

agtcaacaaa taatagagca tccagtgcat ctgccagatt aatgacctct gagtttttga     1320

agaaatctag ttctaaaagg agaactccat cgacaactac ctcttctcac tatttaggga     1380

ctttaaaagt cttggaccaa aaaccttcac agaaacagag catagaacct gatagagcag     1440

ataacataag ggcagctgtt tatcaggagt ggttagaaaa gaaaaatgtg tatttacatg     1500

aaatgcacag aataaaaaga attgaaagtg aaaacttaag gatccaaaat gaacagaaaa     1560

aagctgctaa aagagaagaa gcattagcat catttgaggc ctggaaggct atgaaagaaa     1620

aggaagcaaa gaaaatagct gcca                                            1644


<210> 3148
<211> 926
<212> DNA
<213> Homo sapiens

<400> 3148
ccgcgatggt gagagagccg ggcccccggc cagggacccc cggctgttcg gcctcagggc       60

agtggactgc cactctccgc ccctacctga gtgccgtgcg ggccacattg caggctgccc      120

tctgcctgga gaacttctcc tcccaggttg tggaacgaca caacaagccg gaagtggaag      180

tcaggagtag caaagagctc ctgttacaac ctgtgaccat cagcaggaat gagaaggaaa      240

aggttctgat tgagggctcc atcaactctg tccgggtcag cattgctgtg aaacaggctg      300

atgagatcga gaagattttg tgccacaagt tcatgcgctt catgatgatg cgagcagaga      360

acttctttat ccttcgaagg aagcctgtgg aggggtatga tatcagcttt ctgatcacca      420

acttccacac agagcagatg tacaaacaca agttggtgga ctttgtgatc cacttcatgg      480

aggagattga caaggagatc agtgagatga agctgtcagt caatgcccgt gcccgcattg      540

tggctgaaga gttccttaag aatttttaaa ccatctggct ggatctcgtg gccttccccc      600

tcagactacc catgtctcca cgaaggcgtc ctggagtcac tccccgagca gcgcggcggc      660

ggcagggagt tgggttgggg tgggcatttg atgcgggagg tgggtggtgt gcttgctagc      720

tgggcaagaa agcagcagtg gacctgcccc aaggccacac gtgcctggtc aggctggctt      780

ctgatgttca gtcccctggg ccgggacaga ttttttttaa cgtcttgaaa cttaaactct      840

gtgcttgtag gatactgtaa cctttttgtc tttttttttt tttttttttt taaacctcca      900

cctccagtgg ctgtgactgg tcccag                                           926


<210> 3149
<211> 2084
<212> DNA
<213> Homo sapiens

<400> 3149
ctagcttggc ctcttcccta agaaataaag aaggcacttt ggggtccaag gtagggtact       60

tagatgtgga agcaaggggc cccggggagg ggcggggagg cggcggagag agcccgccgc      120

tgcagccgcc cccgcctgcc cccgtgctcc tgtacgacca gggcgggggc cggcgccggc      180

gcggggaggc cgaggccgag gccgaggagt gggaggccga gtcggtgctg ggcaccctgc      240

tgcagaagct gcgagaggaa ggctacctgg cctactacct ccagggaggc ttcagcagat      300

tccaggccga gtgccctcac ctgtgtgaga ccagccttgc tggccgtgcc ggctccagca      360

tggcgccggt gcccggtcca gtgcccgtgg tggggttggg cagcctgtgc ctgggctccg      420

actgctctga tgcggaatcc gaggctgacc gcgactccat gagctgtggc ctggattcgg      480

agggtgccac acccccacca gtggggctgc gggcatcctt ccctgtccag atcctgccca      540

acctctatct gggcagtgcc cgggattccg ccaatttgga gagcctggcc aaactgggca      600

tccgctacat cctcaatgtc acccccaacc tcccaaactt cttcgagaag aatggtgact      660

ttcactacaa gcagatcccc atctccgacc actggagcca gaacctgtcg cggttctttc      720

cggaggccat tgagttcatt gatgaggcct tgtcccagaa ctgcggggtg ctcgtccact      780

gcttggcggg ggtcagccgt tctgtcaccg tcactgtggc ctacctcatg cagaagctcc      840

acctctctct caacgatgcc tatgacctgg tcaagaggaa gaagtctaac atctccccca      900

acttcaactt catggggcag ttgctggact ttgagcgcag cttgcggctg gaggagcgcc      960

actcgcagga gcagggcagt ggggggcagg catctgcggc ctccaacccg ccctccttct     1020

tcaccacccc caccagtgat ggcgccttcg agctggcccc cacctagggc cccgtggccg     1080

gcaggccggc ccctgcccca cccccaccca cgggtgtccc tgcccactcg tgtggcaagg     1140

gaggggaggg caggagggct cggcctgagc agggtgctgg ggggagagcg caatacctca     1200

cgcgggctgc cgtcctaatc aacgtgccta tggcgggacc acgctcggag cctgcctctt     1260

ctgcgactgt tactttttct ttgcgggatg ggggtggggg ttccctctcc aggtggttgt     1320

ccaggcccat gtcccggccc tgggtgctca gccagctcgg ctaggccctg cgcctccctg     1380

cgcttccccc ttcaggaagg gtgtgtgcca cctcgttgca ctggatccca gtggctgctt     1440

gggggagagg cgtttgccat cactggtgtt gtcacctccc tgtttctcca ccaagggctt     1500

gggcctctcg gggctggggc ctcccagggg atggggaccc agagtgcagt ggccgcccac     1560

atccatggcc taggagctac tgggcaggtt cccggccaca catctggtgg gctgttttgt     1620

tttttttttt tcctcttccc ccagatgtct tgacgggatc actggggctc tttgtgagtg     1680

agggtggcca aactaccgcc ggaggagatg gggtctcaga gcgagagctg cggaggggga     1740

ggggaagaag aaggcctcac ttttgctgct gcggggccca cacagccgct gctactttgg     1800

ggggtgggga aggggccaag ctgcagacac acacagtcat tcatttctgt ccacacccct     1860

gtgggtggcg ggtgtgcgtg tgtgtgcttg tgtgtgcgca cgtgtcggcg ctcacacaca     1920

catgctagcc cactgatgca cccagcccag ggctggcagt ctttgcagcg tggggccgtc     1980

tcaccctgga gcctggagag gatctatgct tgtttgtttt tgtaatccat atcatagttg     2040

ctttctttaa ttgttccttc tgaataaaca gtttatttaa gata                      2084


<210> 3150
<211> 162
<212> DNA
<213> Homo sapiens

<400> 3150
ctagggaccc cgaaatccga ccgcccatgg gaagccactc gccagagtct tacctgagtg       60

aaaaatgcca tggccttgtt tctcatagca ggggattcct taccccatca ccatgtgcac      120

ctcagaaact ttccaagcgc tggacacctt cgaagccaga ca                         162


<210> 3151
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 3151
gagtcaggaa tggagagaag ggtaatggtt ttacctctta ttgtggaaac ctgttgagat       60

cacagagaat atactgacgg cataaaaggg cagaaccata gcagggtgcg cgctgctgta      120

gttgccttcc atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg      180

aacggagacc tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg      240

aagaggaggt gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact      300

gtggccacgt cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc      360

ccgtctgccc actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac      420

tggccagcct ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag      480

aggtgacccg ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact      540

actactgtga ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca      600

ggccccacac ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga      660

accacctgag taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag      720

aagctgatat cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg      780

agtttgagca gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg      840

cgaagctgga gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg      900

agcttgcccg gctggccctg gtcatctccg aactggaggg caaggcgcag cagccagctg      960

cagagctcat gcaggacacg agagacttcc taaacaggta tccacggaag aagttctggg     1020

ttgggaaacc cattgctcga gtggttaaaa aaaagaccgg agaattctca gataaactcc     1080

tctctctgca acgaggcctg agggaattcc aggggaagct gctgagagac ttggaatata     1140

agacagtgag cgtcaccctg gacccacagt cggccagtgg gtacctgcag ctgtcagagg     1200

actggaagtg cgtgacctac accagcctgt acaagagtgc ctacctgcac ccccagcagt     1260

ttgactgtga gcctggggtg ctaggcagca agggcttcac ctggggcaag gtctactggg     1320

aagtggaagt ggagagggag ggctggtctg aggatgaaga agagggggat gaggaggaag     1380

agggagaaga ggaggaggag gaagaggagg ccggctatgg ggatggatat gacgactggg     1440

aaacggacga agatgaggaa tcgttgggcg atgaagagga agaagaggag gaggaagagg     1500

aggaagttct ggaaagctgc atggtggggg tggctagaga ctctgtgaag aggaagggag     1560

acctctccct gcggccagag gatggcgtgt gggcgctgcg cctctcctcc tccggcatct     1620

gggccaacac cagccccgag gctgagcttt tcccagcact gcggccccgg agagtgggca     1680

tcgccctgga ttatgaaggg ggcaccgtga ctttcaccaa cgcagagtca caggaactca     1740

tctacacctt cactgccacc ttcacccggc gcctggtccc cttcctgtgg ctcaagtggc     1800

caggaacacg cctcctgcta agaccctgag ccctgacatc tgcccccagc cccaaccctc     1860

agatgcttca cttctttgga attccaggac tctcaatggg gggacgggat gcctggccta     1920

agcacctgga gcaggggacc ccatatccac tggtagccac ctccccattg ctgtggcccc     1980

ctgaaatctc actcagtgct gttgctccat ctactgccct aatggggctc ttttcccacc     2040

tcctgctggt ttcccgaggg aacttctgac cctggagtcc atgagggctc ctttcctttt     2100

tgaccacgac cttggcccca gctctgcact ctctggaata agggcccgat gcagcatttt     2160

cttgcccagt gtggcaagac ctcagaaaaa ccagtcaatt acgcctaaga tcattttgct     2220

gtccttaaac cccccaggtt ccttcttgca caaatccact ctgctgccca ccttccctgg     2280

cattttaaac agacctaccc caccccaact cagagttaag catacatggc aatgctgaaa     2340

ataaacaaaa tccactgagg cttcccaggc catttaaagc ctggagtacc agcgcatatc     2400

atctcatggg gtccagagtg gagtccaggc ttctctgaaa ccagggctga gcatatttcc     2460

atagccaagg aggtgggact ccctggagct atctgtggtc ttagggaagg atccagacat     2520

acacggcttt ggggtacaag ctgtgatcac tgatcaataa attatctcta gattggtcct     2580

tgtgagggga gttttaagaa tccagaacat cttgctcttg atcagcacat ccaaaaacac     2640

caagacaaac atccagtgga gcagaacctc tcctgcctcg ggagttctga ccgggttccc     2700

cagcagggtg ttaagcctct gtctctggcc ctaccagcat ccaggttcca ctttcctagg     2760

agagagtgga gatgggaaga cagggaaagg aaggcagcag gaggccacaa gcccaccagg     2820

tcttcatgtc aagagaggga gtaacatgtc ttctcattgc ccacggaccc aacctctgtc     2880

caggtgcccc tcatcatcac agtttaacac aagctcccct gctccagcca aattgatctc     2940

ccagtcttgt ccttacccat tccaagtgct ctgccagccc ctgttcatcc aagttttaag     3000

tcctccaccc tgttctaaga gactgttcca acggctctgg gcctcagtgg tcacttgacc     3060

accattgtct cagagctgcc cactttgtgt gtgtcacatg ctgcctgagt cacatgtaca     3120

tcttatttct gcctctagtt ttgtaagctc ctggagggcg gataacatct tatactactc     3180

ttgtattctc atggcaccta gtgcagtgct gggcacagag taggtgctca ataaagactt     3240

gttgaatgaa                                                            3250


<210> 3152
<211> 603
<212> DNA
<213> Homo sapiens

<400> 3152
gtgcaggagc gggacccgga acagaccgcc gtgagagagg aggggcgccg gccgggattc       60

gcggcccgga gctcgggacc ggagaagaag tcctcaccag tgaacggaga cctctctgaa      120

ctaaggatac catggccacg tcagccccac tacggagcct ggaagaggag gtgacctgct      180

ccatctgtct tgattacctg cgggaccctg tgaccattga ctgtggccac gtcttctgcc      240

gcagctgcac cacagacgtc cgccccatct cagggagccg ccccgtctgc ccactctgca      300

agaagccttt taagaaggag aacatccgac ccgtgtggca actggccagc ctggtggaga      360

acattgagcg gctgaaggtg gacaagggca ggcagccggg agaggtgacc cgggagcagc      420

aggatgcaaa gttgtgcgag cgacaccgag agaagctgca ctactactgt gaggacgacg      480

ggaagctgct gtgcgtgatg tgccgggagt cccgggagca caggccccac acggccgtcc      540

tcatggagaa ggccgcccag ccccacaggg aaaaaatcct gaaccacctg agtaccctaa      600

gga                                                                    603


<210> 3153
<211> 2549
<212> DNA
<213> Homo sapiens

<400> 3153
atggaaccag agaggaaggg gctatcgttg gcttcttctt cagatggaga cgggagagaa       60

gaaaataaat taaaacaagg aatttcccaa gacttggctt cttcctccag attagacaga      120

tacaaaatag caaggcagtt aacagaaaaa gcaatcaagg agaagaagat tttctctatc      180

tacggacact acccggtggt ccgggccgct ctgcgaagga agggctgggt agagaagaag      240

ttccactttt tgcccaaggt cattccggat gtcgaggatg aaggcgcccg ggtcaatgat      300

gatacatgtg ccaaagtcaa agaaaatcaa gaaatggctt tggagaaaac agacaacatc      360

cacgacgtga tgtctaggtt ggtaaaaaat gagatgccgt acctcctctg gaccatcaag      420

agggacatca ttgactatca cagcctgacc tacgaccaga tgctgaacca ctacgcaaag      480

acagcctcct tcaccaccaa gatcgggctg tgcgtgaaca tgcggagcct gccctggtac      540

gtcccggcca accccgactc cttcttccca cgctgctaca gcctctgcac cgagagtgag      600

cagcaggagt tcctggaaga cttccggcgc accatggcat ccagcatcct caagtgggtg      660

gtcagccacc agagctgcag caggagcagc agaagcaagc ccagggacca gagggaggag      720

gccgggagca gcgacctgag cagcaggcaa gatgctgaaa atgctgaggc aaagctcagg      780

ggcctcccgg ggcagcttgt ggacatcgcg tgcaaggtgt gccaggccta cctggggcag      840

ctggagcatg aggacatcga cacgtcagca gatgccgtgg aggacctcac tgaggccgag      900

tgggaggacc tgacccagca gtactactcc ctcgttcatg gcgatgcttt catctccaat      960

tcaagaaatt acttttcgca gtgccaggct ctgctgaata gaatcacgtc tgtgaaccct     1020

cagacggaca ttgacgggct ccggaacatc tggattataa agcccgcggc caagtcccgg     1080

ggccgagaca tagtgtgcat ggaccgtgtg gaggagatcc tggagctggc agctgcagac     1140

caccctcttt ccagggacaa caagtgggtg gtccagaagt acatcgagac gccgctgctc     1200

atctgtgaca ccaagttcga catcagacag tggttcctcg tcacggactg gaaccccctg     1260

accatctggt tctacaagga gagttacttg cggttctcaa ctcagcgctt ctccctggac     1320

aagctggaca gcgccatcca cctgtgcaac aacgccgtcc agaagtacct gaagaatgat     1380

gtgggccgca gccccctgct gcccgcacac aacatgtgga ccagcaccag gttccaggag     1440

tacctgcagc gccagggccg tggcgccgtg tggggcagcg tcatctaccc gtccatgaag     1500

aaggccatcg cccacgccat gaaggtggcc caggaccacg tggagcctcg caagaacagc     1560

tttgagctct acggggctga cttcgtcctt gggagggact tcaggccctg gctgatcgag     1620

atcaattcca gccccaccat gcacccgtcc acgccggtca cggcccagct gtgtgcacag     1680

gtgcaggagg acaccatcaa ggtggccgtg gaccgcagct gtgacatcgg caacttcgag     1740

ctcctgtgga ggcagccggt ggttgagccg cccccattca gcgggtccga cctctgcgtg     1800

gcgggcgtca gtgtgaggag agccaggagg caggtgctgc ccgtctgcaa cctcaaggcc     1860

tcggcctcgc tgttggacgc gcagccgctg aaggcacggg gcccctcggc catgccagac     1920

cctgcccagg gacccccatc accagctctc cagcgggact tgggactgaa ggaagagaag     1980

gggctccccc tggccttgct ggcaccctta aggggggcag ccgagagcgg tggagccgca     2040

cagcccaccc gcaccaaagc tgctgggaag gtggagctcc cggcctgccc ctgtcgccac     2100

gtggacagtc aggccccaaa caccggtgtc cccgtagccc agcccgccaa aagctgggat     2160

ccaaaccagc taaatgcgca cccgctggag cctgtgctgc ggggcctgaa gacagcagag     2220

ggcgcgctgc gtccgccgcc cggaggaaaa ggagagggca cggtctgcag ccgcctgcca     2280

caccacgggc accacgtggc cgcctgccag accacgggca ccacgtggga tggtgggcct     2340

ggggtgtgct tcctccggca gctcctggca tcagaactgc ccatgggccc tgggctgccg     2400

agggaccccc gagcgccgcc ctgcctcgtg tgccgcgggc tgctgccacc cgccgggccc     2460

tgcaagcgct gccgctcgtt ctgcgccgcg gtcctgcagg gcgcgtcctt cgtgcggctc     2520

ggcgggcgga gctgcagccc gcggacccc                                       2549


<210> 3154
<211> 3599
<212> DNA
<213> Homo sapiens

<400> 3154
aacaaccccg aggtcttatt tttatagaat atcaagaaca aaatcttcca aaaggcacac       60

gatgccaaac taaaaataaa gagcgaaaac ccaaaaagtc gcgctcaatt ccttctgaaa      120

cctattcgcc tcctacccct gtcccatcct ctggcgctgg cgggtcctcg tccccgtttt      180

ccccaccgca agtcctggaa cctccgctta actcttttct cggcggctcc gccccggccc      240

cgccccagcc atgccttggc cccgccccgt tcgccgttta ttggcttctc ccaacccctg      300

ccggtgggtg acaagccggg aagcttggag gggtctattg cgtacgccca aggcgctggg      360

cctggagcag gagaaaggga gtggaggcgc gtcggagact atgaagcgcg gcattcggcg      420

ggatcctttc cggaagcgga agctcggcgg gcgggccaag aaggtccggg agcccacggc      480

ggttaattct ttttaccgtg aggcttcact tccctcggtc tgggcttctc tgaggcggcg      540

agagatggtc aggtctggag ctcgaccggg ccaggtgtta tcttcaggaa ggcacactgg      600

acctgctaaa ttaacaaatg gaaagaaagc gacctattta agaaaaatac cacgttttaa      660

tgcagattct ggctattcca tccattctga ttcagaaagt caggctgaaa ctgtacacgg      720

gcttgatggt tgtgcttctt tgctgaggga cattttgaga aatgaagatt cagcatcttc      780

agataataag aaacagatac ctaatgaagc ttctgctaga agtgaaagag acacatcaga      840

cctagagcaa aactggtcat tgcaagatca ttatagaatg tattcaccca taatatacca      900

agccctctgt gagcacgtgc agactcagat gtcactgatg aatgacttga cttcaaagaa      960

catccctaat ggaattcctg ctgtaccatg ccatgctccc tctcattctg aatctcaggc     1020

aactcctcat tctagttatg gcttatgtac ctccacccca gtctggtcac ttcagcggcc     1080

accctgccct ccaaaggttc attctgaagt tcaaactgat ggcaacagtc agtttgcatc     1140

acaaggtaaa acagtttctg caacctgtac tgatgttcta cggaattcat ttaataccag     1200

tcctggagtt ccatgtagcc tgcccaaaac tgacatatca gctattccaa cattgcagca     1260

actgggcctt gttaatggaa ttctgccaca acaaggaatt cataaggaaa cagacctact     1320

aaaatgtatt caaacatatt tgtctctttt tcgatctcat ggaaaagaaa cgcatctgga     1380

cagtcagaca caccgaagcc ctactcagtc acaaccagct ttcttggcca ctaatgaaga     1440

aaaatgtgcc agagagcaaa ttagagaggc cacaagtgaa agaaaggatt taaacataca     1500

tgtgcgagat acaaaaacag tgaaggatgt acagaaggca aaaaatgtga acaagacagc     1560

tgaaaaagtt agaattataa aatatttgtt gggagagctc aaggccctgg tagcagaaca     1620

agaggattca gaaattcaga ggttgattac agaaatggag gcatgtatat ctgtacttcc     1680

aacagtaagt ggaaacacag atattcaagt tgagatagca ctggccatgc aaccattaag     1740

aagtgagaat gctcagttac gaaggcagtt gagaattttg aaccagcaac tcagagaaca     1800

acagaaaact caaaaaccat ctggtgctgt ggattgcaac cttgaattgt tttctcttca     1860

gtcattgaat atgtcactgc aaaatcaatt ggaggagtca ctaaagagcc aggaattact     1920

gcagagtaaa aatgaagagc tgttaaaagt gattgaaaat cagaaagatg aaaacaaaaa     1980

atttagtagt atatttaaag acaaagatca aactatactt gaaaataaac agcaatatga     2040

tattgagata acaagaataa aaattgaatt ggaggaagcc ctagtcaatg tgaaaagctc     2100

ccagtttaag ttagaaactg ctgaaaagga aaaccagata ttggggataa cattacgtca     2160

gcgtgatgct gaggtgactc gactaagaga attaaccaga actttacaga ctagcatggc     2220

aaagcttctc tccgatctta gtgtggacag tgctcgctgc aagcctggga ataaccttac     2280

caaatcactc ttgaacattc atgataaaca acttcaacat gacccagctc ctgctcacac     2340

ttccataatg agctatctaa ataagttaga aacaaattac agttttacac attcagagcc     2400

actttctaca attaaaaatg aggaaaccat agagccagac aaaacctatg aaaatgttct     2460

gtcctccaga ggccctcaaa atagtaacac taggggcatg gaggaagcat ctgcacctgg     2520

aattatttct gccctttcaa aacaggattc tgatgaaggg agtgaaacta tggctttaat     2580

agaagatgag cataatttgg ataatacaat ttacattcct tttgctagaa gcactcctga     2640

aaagaaatca ccactttcta agagactatc ccctcagcca caaataagag cagctacaac     2700

acagctagtc agcaacagcg gacttgctgt ctctggaaaa gaaaataaac tgtgtacacc     2760

tgtaatctgt tcctcttcaa caaaggaagc agaagatgca cctgaaaaac tttccagagc     2820

atctgatatg aaggacacac agctcctcaa gaaaataaag gaagcaattg gtaagatccc     2880

tgctgccacc aaggagccag aggaacaaac tgcatgtcat ggcccatcag gttgtcttag     2940

caacagcctt caagtgaaag gcaatactgt ctgtgatggt agtgttttca cttctgactt     3000

gatgtctgac tggagcatct cttcgttttc aacgttcact tctcgtgatg aacaagactt     3060

cagaaatggc cttgcggcat tagatgccaa catagctaga ctccagaagt ctttaaggac     3120

tggtcttctg gagaaatgaa ttcagaagaa aactcatcag gtgcttcttt ttaaaactag     3180

aacttggcta tattgaatgt gtatttttct ttagtgaaat gatgttttat gttattatgt     3240

gtgaagtaat atattgtaca agtaataaat gtattgttga gatatattga cactgaggag     3300

cttataaaaa caagtcatct taagttcaca attgctacaa gaagaaagtt gtggataact     3360

aggaaattat tgtaagtaat gttttatttc agtacttagc aattagagtt cttttattaa     3420

gatgtatctg ctggattaag ggtacaggtt gaaatagttc tgtggctgtc ctaagaaata     3480

atgggaaaag aatctctgga tgtaagtttt tctgttgaaa ctagagggtt ttttttttct     3540

gtttacatat actttttttt aatagcaatg tgtttttatt aaacatgctg tgtgccaca      3599


<210> 3155
<211> 713
<212> DNA
<213> Homo sapiens

<400> 3155
cccttctgag caatggagct taccatcttt atcctgagac tggccattta catcctgaca       60

tttcccttgt acctgctgaa ctttctgggc ttgtggagct ggatatgcaa aaaatggttc      120

ccctacttct tggtgaggtt cactgtgata tacaacgaac agatggcaag caagaagcgg      180

gagctcttca gtaacctgca ggagtttgcg ggcccctccg ggaaactctc cctgctggaa      240

gtgggctgtg gcacgggggc caacttcaag ttctacccac ctgggtgcag agtgctgaga      300

ccgggagggg ctttctattt catggagcat gtggcagctg agtgttcgac ttggaattac      360

ttctggcaac aagtcctgga tcctgcctgg caccttctgt ttgatgggtg caacctgacc      420

agagagagct ggaaggccct ggagcgggcc agcttctcta agctgaagct gcagcacatc      480

caggccccac tgtcctggga gttggtgcgc cctcatatct atggatatgc tgtgaaatag      540

tgtgagctgg cagttaagag ctgaatggct caaagaattt aaagcttcag ttttacattt      600

aaaatgctaa gtgggagaag agaaaccttt tttttggggg gcggtttttt tggtttgttg      660

ttggtttttt tttttttttt ggcgggaaga aagagttttg ctcttgttgc cca             713


<210> 3156
<211> 3772
<212> DNA
<213> Homo sapiens

<400> 3156
gccgccgccg ccgccgccgc cgcgccgcgg cttgagggcg ggaggctggg ggagggtagc       60

ggagccggcg ccgccgccat gttgggtctg aagcggctgc tgtaggcgcc gacggagcga      120

gcgggcgtgc ggagcgggcg acagtggcgt gggatctgcc tctctgcgag cagctgggag      180

cggcggcggc ggcgccatga gcgggggcac cccttacatc ggcagcaaga tcagcctcat      240

ctccaaggcg gagatccgct acgagggcat cctctacacc atcgacaccg aaaactccac      300

cgtagccctt gccaaagttc gatcctttgg tacagaagac agaccgacag atcgtccaat      360

accacctcga gatgaagtct ttgaatacat tatattccgt gggagtgaca ttaaagacct      420

tactgtttgt gagccaccaa aaccacagtg ttctttgcct caagacccag ctattgttca      480

gtcctcacta ggctcatcga cttcttcatt ccagtccatg ggttcttatg gacctttcgg      540

caggatgccc acatacagtc agttcagtcc gagttcctta gttgggcagc agtttggtgc      600

tgttggtgtt gctggaagct ctttgacatc ctttggaaca gaaacatcaa acagtggtac      660

cttaccccaa agtagtgcgg ttggttctgc ctttacacag gatacaagat ctctaaaaac      720

acagttatct caaggtcgct caagccctca gttagaccct ttgagaaaaa gcccaaccat      780

ggaacaagca gtgcagaccg cctcagccca cttacctgct ccagcagctg ttgggagaag      840

gagtcctgta tcaaccaggc ctttgccatc tgccagccaa aaggcaggag agaatcagga      900

gcacaggcga gctgaagtac acaaagtttc aaggccagaa aatgagcaac tcagaaatga      960

taacaagaga caagtagctc caggtgctcc ttcagctcca aggagagggc gtgggggtca     1020

tcggggtggc aggggaagat ttggtattcg gcgagatggg ccaatgaaat ttgagaaaga     1080

ctttgacttt gaaagtgcaa atgcacaatt caacaaggaa gagattgaca gagagtttca     1140

taataaactt aaattaaaag aagataaact tgagaaacag gagaagcctg taaatggtga     1200

agataaagga gactcaggag ttgataccca aaacagtgaa ggaaatgccg atgaagaaga     1260

tccacttgga cctaattgct attatgacaa aactaaatcc ttctttgata atatttcttg     1320

tgatgacaat agagaacgga gaccaacctg ggctgaagaa agaagattaa atgctgaaac     1380

atttggaatc ccacttcgtc caaaccgtgg ccgtggggga tacagaggca gaggaggtct     1440

tggtttccgt ggtggcagag ggcgtggtgg tggcagaggt ggtaccttca ctgcccctcg     1500

aggatttcgc ggtggattca gaggaggtcg tgggggccgg gagtttgcgg attttgaata     1560

taggaaaacc acagcttttg gaccctaaaa ggtctggatt gatcgtactg ctttctgaaa     1620

gaaagacaac aaagttgctg catagtctac aaacaagtct ctgaaaatag gtgaatttct     1680

agctcttcat ggtcctgaac attgatttca gtctttgcaa agaatgaaga agtgaattcg     1740

ctgtacattt gtcaccagca ctgggttttt gttttttgtt tgtttttccg cttaatttca     1800

aagataaaat gcagttactt ttgggggtgg aaggctcatc ttaaaacatg agcattaaat     1860

atatttggaa tagcagaagg ttaagtaatt tcttatgtat agttaaacta aagcagtact     1920

tcagtgggac ttaacaagta ttttttcatc actgaaaggt tttttttttt tatcactaaa     1980

ttgtatttgg caattgcaag ttgcctgcag atagggccgt gatactgtgt tttgagccac     2040

agaaggttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gtgtgtcttt     2100

ttcctccttt cttttgggga atcctgtaat atgaggtagc ttatttcgtc aattaattag     2160

ggtgctggat ggtagagaat tttgtcagtc aactatgtac acacagtaaa tactgtttct     2220

taggcaaagg taactttttt atatagttgt aaaattccat tatattccat tgccaaagaa     2280

acattaagaa ctttgtatag ctgtataaaa agcaactaat tttttaaaga ataaacattt     2340

taaagtcagc aaacatactg tgtccttgca gaagttgatg tgctgagcag cagccttatg     2400

ggtgggtctt tttttcttag ttttccaggc ttaacatttt tgattttgtt ttttaatgtt     2460

tggaacataa atgaagattt gatacattat ttcattatct aaaaaggatt aattattcat     2520

gctcattgta agaacttcat tttgtagcaa atggcatatc acaggatctg tccagataat     2580

cgatattttc agtatacaaa tgtaaataat cacagatgag aatgtactta gctgtatttt     2640

caaataagta atcttccccc cttttgtagg actttaaaac taggcatcaa tgaacctgtt     2700

tttcctatta tgcctggaat ttagtcatga taccttgact cattccatca tatttcaaga     2760

ggattcagag tgctagaaat tattttggta gcctgtaaca cacggcaaca ctggtccttg     2820

ggcctatgat gacccacaga tgactcagta tagagttcat tgctaattat aaattactag     2880

tgaatctttt tgatatttta agctctagtg ggaaaaatct ggccactttt gtgtttttat     2940

gaaggccatg gaataaaagg atccaaagat ttaaatattt ttatctaata ttttgattgt     3000

tttcttaact ttctccttaa aacattcagt agtgataaag atatagaaac tgcactgtag     3060

gagaattgga atatttaagg ctggttgaca ttttttattt tcattttata tcttttgtat     3120

agctctacaa ggcagtgttt tgtaatttgg tttcattatg aagatccagt acttggcagc     3180

catagtttag acaatattgt tcagtgctgt ttgcttgcat gttaacaaca aaacctttta     3240

gaggacccac aaatcatgat attgaacaca gttccgaggc attcagagca tcagagcaag     3300

taccatggca atacatgtgt agactgttgg agatgtcccg ggccaatttc aagaaagaaa     3360

actgtaaata ctagttctac ttgctctgaa attatgagtt tatgcgtttt cccagccctc     3420

cgaatcactg actggggcgt tttgtgcccc agcaataact ggcagcatgg catacctgca     3480

gtacccctta caatattaaa gcaaagtttt tattctaaaa cagaataaaa ctgttcaata     3540

aaaaatgctc gtcaaagttc tttctcttta aatagtaaca ttctgtttca gtaggaacat     3600

aatgaaagga atcttttaaa tggaagagcg gaattataat gtttgtattc cctgtaataa     3660

ctataaatca gttactttat ttctaagatt gagttattgt tgcagatgtt tagggaaagc     3720

taaaagcccc ttccttcccc tcctgtgtgt aaataaaata cttctgagat ca             3772


<210> 3157
<211> 5669
<212> DNA
<213> Homo sapiens

<400> 3157
agactgaggc tggctggctg gaggttgaca caggagtgct caggggagca gcatcacaag       60

agggcagatc gaaagcatcg tccttgctga aaaacagatg gcagaggtgg aagcggtaca      120

gctgaaggag gaaggaaacc ggcatttcca gctccaggac tacaaggccg ccacaaatag      180

ctacagccag gccctgaagc tgaccaagga caaggccctg ctggccacgc tttatcggaa      240

ccgggcagcc tgtggcctga aaacggagag ctacgtccag gcagcttcag atgcctccag      300

agccatcgac atcaactcct cggacatcaa ggctctgtat cggcgatgcc aggcactgga      360

gcacctgggg aagctggacc aggccttcaa agacgtgcag cgttgtgcca ccctcgagcc      420

acggaaccag aacttccagg agatgctgag gagactcaac accagcattc aggagaagct      480

ccgagtgcag ttctccacag actcgagggt acagaagatg tttgagatcc tcttggatga      540

aaacagtgag gctgataagc gggaaaaggc tgccaacaat ctcattgtcc taggccgtga      600

ggaagcaggg gctgagaaga tcttccagaa caatggagta gccttgctac tgcagcttct      660

ggacactaag aagcctgagc tggtgctggc tgcagtgcgg accctgtcgg gcatgtgcag      720

cggccaccaa gccagagcca cagtgattct gcatgcagtg cggatagacc gaatctgtag      780

cctcatggcc gtggagaatg aggagatgtc tctggctgtc tgcaacctgc tccaagccat      840

cattgactcc ttgtctgggg aggacaagcg ggagcatcga gggaaggagg aggccctggt      900

tctagacacc aagaaggacc tgaagcagat caccagccac ctgctggaca tgctagtcag      960

caagaaggtg tctggccagg gcagggatca ggcgctgaac ctgctcaata agaatgttcc     1020

caggaaggac cttgccattc atgacaactc acgtaccatc tatgtggtgg ataatggtct     1080

gaggaagatc ctgaaggttg tggggcaggt tccagatctg ccatcctgcc tgcccctgac     1140

tgacaacacc cgcatgctgg cctctatcct catcaacaag ctctatgatg acctgcgctg     1200

tgacccggag cgcgatcact tccgcaagat ctgtgaggaa tatatcacgg gcaagtttga     1260

cccccaggac atggacaaga acttgaatgc catccagaca gtgtcaggga tcctgcaggg     1320

cccctttgac ctgggcaacc agctgctggg actgaaaggt gtgatggaga tgatggtggc     1380

actatgtggc tcagagcgcg agacggacca gctggtggcc gtggaggccc tcatccatgc     1440

ctccacgaag ctcagccgcg ccaccttcat catcaccaat ggagtgtcac tgctcaaaca     1500

gatctacaag accaccaaaa atgagaagat caagatccgc acactggtgg gactctgtaa     1560

gctcggctct gcaggtggca cagactacgg tctcaggcag tttgcggaag ggtcgacaga     1620

aaaactggcc aaacagtgtc gcaagtggct gtgcaatatg tccatagaca ctcggacccg     1680

acgctgggca gtggagggcc tggcctacct cacgctggac gctgatgtga aggacgactt     1740

tgtccaggac gtccctgccc tgcaggccat gtttgagctg gccaagacca gtgacaagac     1800

catcctgtac tcggtggcca ccaccctggt gaactgcacc aacagctacg atgtcaagga     1860

ggtcatccca gagcttgtcc agctcgccaa gttctccaag cagcatgtgc ccgaggaaca     1920

ccccaaggac aagaaggact ttatagacat gcgggtgaag cggcttctga aggcgggtgt     1980

catctctgcc ctggcttgca tggtgaaagc agatagtgcc atcctcactg accagaccaa     2040

ggagctgctg gccagggtat tcctggcact gtgtgacaac ccaaaggacc gaggcaccat     2100

tgtggctcaa ggtggtggca aggccctgat tcccctggct ttggagggca cagatgtggg     2160

caaggtgaag gcagcccacg ctctagcaaa gatcgctgct gtctccaatc cggacattgc     2220

ttttcctggg gagcgggtgt atgaggtggt gcggcccctt gtaagactct tggacacaca     2280

gagggatggg cttcagaact atgaggctct cctaggcctc accaacctgt ctgggcggag     2340

tgacaaactc cggcagaaga tctttaagga gagggccttg ccagacatcg agaactacat     2400

gtttgagaat catgatcagc tgcggcaggc ggccaccgag tgcatgtgca acatggtgct     2460

ccacaaggag gtacaggaaa ggttcttggc tgacgggaat gaccggctga agctggtggt     2520

gctgctctgc ggggaggatg atgataaggt gcagaatgcg gctgcagggg ctctggccat     2580

gctgacagca gcacacaaga aactgtgcct caagatgact caagtgacaa cccagtggtt     2640

ggagatcctc cagcggcttt gcctgcacga ccagctgtct gtccaacacc ggggcctggt     2700

cattgcctac aacctactgg cagccgatgc tgagctggcc aagaagctgg tggagagtga     2760

gctgctggag atcctgactg tggtgggcaa acaggagcca gatgagaaga aggcagaagt     2820

ggttcagaca gcccgagaat gtctcatcaa gtgcatggat tatggtttca ttaaaccagt     2880

gtcttagaca gcgaccctca gggatgctgg gagtggtcct gtactgtgca gagtcctggg     2940

ttggttgggt tctcctgaag agtcaggtca tctagggatc atagcagtga caatgaagtc     3000

tcaatataaa ggaaagactt gattgttctc tgagttgtga gtcttctcct ttgtcctgac     3060

agagtttgga tgtttcactc tctctcttgc ttcctgtctc cttatatttg tcatgtttca     3120

gaaattccca gaataatttt cacccatgat tagaaatagg ttggatcatt ctttctgtac     3180

ccattctgaa ggccaggata ataggttgaa gttctttata ttttggaaaa tggattttgt     3240

ggtaaggtag gaactaacgg gtgtgtgcat ataaaggtta atgctgttgt atttggatgc     3300

tgatctgtgc tgttttcatg acctctctcc cacactattt gaatcagtct gttcagaact     3360

gtgtgtttca cctgcagtgc tctgtcccag tcccatgccc attcccatca cttcactgtg     3420

atggaaatag agtttatgtt caacagtggg gcatgacctc tgcaatttgc ttgggaaagt     3480

cttccaagca agatggacat gatgaataca aataagatct actcaaagta cttcaaacaa     3540

aaaataaata attcattggc tcatgtatct tggccaccca gggaaggtct gacattgtta     3600

gttagatcca gagtttcaaa tgtcatcacc atggatgtgt ctttttctct ctctcatttc     3660

ccctccccat atcttgtctt ttatttatta taggtttgtc tcattccctg gcaggctctc     3720

tccctgtgat aggaaagaga gtccccagca gccccagggt gacatagttg ttatagttca     3780

ttatggaata gaagagagaa gagcattctc aataacccgg caaagttccc agggatgact     3840

ctgatatgtc tatgtctcag gtcacatttc catctatgaa ccaatcatat tcagaggtgg     3900

aatgctaatt ggccaggcct gggtcatata tacaagtcta gggaagaaat gagcttcatc     3960

cctgtccaat tgacatggac tgattagggg tattaatgga agaggtgtgc caccacaaaa     4020

gaatgtaccc tgggcagatc aaagaacata ttctgtatgt caggcttggc cacaaaagaa     4080

tgacacaagt aatatgctgt agatcagaac ctctctgcta atattgcctt tttagcatgg     4140

ttaagatagc taagatctag tactgtcact ccagtatgtc ccaattctac ctacgtttat     4200

tgaagggtca acagttctga tctcagcatt gggtaaaggg tgggacattc agatttacgg     4260

tccttgataa aaacaattta caacgttccg ttgtgtaata aatgtaagtg tacatatgcc     4320

tgggacatca gctggaaaag ggacagacta tcagagagtt gcactgttgc ggtatgggcc     4380

aaatccaaca taatacccgc tgtacctcta gagaactaaa accttaattt ctcagatctt     4440

ttctgcacta atggtcttta catacagcct acattttaac taactcttgc atgggcttgt     4500

ttcacagcag gaaactatat tcatcatatc cttattatga tagagaatga caacattcaa     4560

aagggtgtgg tgcttctgaa aatatacaca ataaatggca tgatttgacc tctgtcaaat     4620

tcttctttcc tgctttcctc atatgtgggc ttgagtgggt gtatttagct cctttaaagg     4680

aaactctttc acaggcaggg ccacactctt actcgttttg atctcatgag gttacatctg     4740

ccagtggcgt tcagggccag ttagataaag ttcatcttgt ttggattgga gagacttttt     4800

tttttttttt ttttgagaca gggtcttgct ctgtaaccta ggctcaagtg cagtgcagtg     4860

gtgcagtcat ggctcaccgc agccttggtc tcctgggctc aagtgatctt tctacttcag     4920

cctcctcaat agctgggact acaggcacac accaccaccc ccaggtaatt aaaaaatttt     4980

tttttgtaga gacagggtct cactatgttg cccagtctgg gagaccacat tctttaacat     5040

gaatattttg taaatagtcc aagaagatct agaggaaagc tgaattcctt catctgattt     5100

ttgccactgg gctgcctccc attgtctggc taagtcttca tgggaggcct ttaagaaaag     5160

ctgtgacaaa tacctttgtt tcccactgcc taggttacat aagtagttgg cttttccagc     5220

ctagactctt atattgttgc ttgtaagagg gcccttcttt gcagatttct tttttttttc     5280

atctatgctt tcaaataggc agatgctagc ctgagatcat ctctttattg aggtagtttg     5340

cccaaaaaca gcaaggaaca gccaatacct gccaactttc taggtttttc caaccaattc     5400

tcttacagaa aatctataaa tatcttagag gtatgtttct tagtttccca acatataatg     5460

ggaaaattca tcatttatat tattactttt aactgaagta tgttgttatc agagaacttg     5520

gtctgtgtca tattaatcct ttgccatttg agaagcatac agttttaaag tttatatctc     5580

caaaaggata ttttgtaaaa atttaacccc tttgactctt agtcttctca tttgtgaaag     5640

gtaaataata aagaatttct gttcctagt                                       5669


<210> 3158
<211> 246
<212> DNA
<213> Homo sapiens

<400> 3158
atgagtcact acggcagcta ctacggaggc ctgggctaca gctgtggagg cttcggtggc       60

ctgggctatg gctatggctg tggatgtggc agcttctgca gacggggttc tggctgtggc      120

tatggaggct acggatatgg ctctggcttt ggaggctacg gatatggctc tggctttgga      180

ggctatggat atggctgctg ccgcccatcg tacaatggag gatacggatt ctctggcttt      240

tattaa                                                                 246


<210> 3159
<211> 206
<212> DNA
<213> Homo sapiens

<400> 3159
ggccggcaga gagagcctgg atacgaagca ggcgggcttc agagtgggtt ggaaaaatgg       60

aggtgccgcg cctggatcat gccctcaaca gccccaccag cccctgtgag gaggtgatca      120

aaaacctcag cctggaggcc attcagctgt gcgaccggga cgttgttttt gaagaactta      180

catccaaaca gacaagaaaa ggataa                                           206


<210> 3160
<211> 1918
<212> DNA
<213> Homo sapiens

<400> 3160
ggacgcctgg tgttctcgcg ggaaagaacc gttgcgcccg actttgcgcg gaggtaggag       60

ggggaagtgg aggcgggagt gaagtctcgc gagaagagtc ggttgccgta gcagagccct      120

ctagctgtgt gtgtctgagg ctcggccgcc tgagccgcgg acggtttgct gagcccgtta      180

gtgcgcccgg ccgagacacg ccgccgccat gtcccgctac ctgcgtcccc ccaacacgtc      240

tctgttcgtc aggaacgtgg ccgacgacac caggtctgaa gacttgcggc gtgaatttgg      300

tcgttatggt cctatagttg atgtgtatgt tccacttgat ttctacactc gccgtccaag      360

aggatttgct tatgttcaat ttgaggatgt tcgtgatgct gaagacgctt tacataattt      420

ggacagaaag tggatttgtg gacggcagat tgaaatacag tttgcccagg gggatcgaaa      480

gacaccaaat cagatgaaag ccaaggaagg gaggaatgtg tacagttctt cacgctatga      540

tgattatgac agatacagac gttctagaag ccgaagttat gaaaggagga gatcaagaag      600

tcggtctttt gattacaact atagaagatc gtatagtcct agaaaaccaa actgcagctg      660

gaatacccag tacagttctg cttactacac ttcaagaaag atctgaaagc ggaaaaagaa      720

ccaaagaagg gcagttcaag cgaccaaagg gtgggtggaa ggtgctgcag tatgaatact      780

gtacgaatat tttgactctg gtctgaaaag ataaaagaat gttatcgaaa actacatgga      840

ataattgaag tcccttcaag tttgaaagta agcattttag gacaaataaa aggaaattca      900

actttgtact tgtggaaact aatccctaaa tatgaatagg tttatattga ttcatgggta      960

acaggtccat aataaattat tggaaactag gatgtctgaa tatcaaggaa gacagccata     1020

gtctcttaca gtgcctctgt tggtctgtct caaactgaat tgggtgggaa aaggtatggt     1080

ccaatataaa agttccattt ttgccattat tggcaaatct tgcctttgtt tattttggtg     1140

ccagtgtttt ctgcttaatc atttgctttg ttggcatctg tgtttattta cttgtacacc     1200

acatgcagtt tacatctgtc ttaactactc cttcccaggt aaattccaat tatatttgac     1260

atccagctaa gagggcccat ctcttctcac ctctttccta gtcagtatat tcagcaaata     1320

tttattgagc ccttactgtg ggcaaatcat tgtactggat aattgagaaa aatagataat     1380

tcccttattc agtaaatgtc tactgagcac aatctagtga atcattacag tatggcctca     1440

ttgttttgtt tgaggtgtgt tattcataac aatattttac accattcgta tcaatgtaat     1500

tatagaacac aatatacgat caaggataag taattgtgtg gttatctgcc atttaaaagt     1560

atccagtatt tgatcacatt attataaata atgaaaaaat gatttaatct gtaataaact     1620

ggtttattgt gcagtgactg taatatacta gagttataat aaattgttta ctctgcctca     1680

ccaaacacat gctaggatat aacccccaaa ataagtattt aactttgcat taggtataaa     1740

ggagactggg tgctataatt agattatttt gaggcagaca gagagctgtt atcctaactg     1800

atttagtatg ttctgtaatt gagaaaatgt tcaccaaatt atacttttta gtgatttaca     1860

tgtacatttt ataggggaca tgttctgtgt atagcgaata aataactttt atagtatc       1918


<210> 3161
<211> 2119
<212> DNA
<213> Homo sapiens

<400> 3161
tcgtcatggc cagtgtctgt ctggcgcccg gtgcccaggc actgtgcgag accagtccgc       60

aggggcgact cggagagcgc cgggccgcgg cgggagaaga gcctgcagcg attaaagtga      120

agaaacaatg gccagcaatc acaaatcttc agcagctcgc cctgtttcaa gaggtggagt      180

tgggttaaca ggaaggcctc cttctgggat acgaccccta tcaggaaata ttcgagtggc      240

aactgcaatg ccacctggga cagcaagacc aggttctcgt ggttgtccca tagggactgg      300

tggagttctg tcttctcaaa tcaaagttgc ccatcgccct gtaacacaac aaggtttgac      360

tggaatgaaa actgggacga aaggtcccca gaggcaaatt ttagacaaat cttactatct      420

tgggcttctt agaagtaaaa taagtgaact tacaactgaa gttaataaac ttcagaaggg      480

aatagaaatg tacaatcaag agaattcagt atatttgtca tatgaaaaga gggctgagac      540

tttagctgtt gagataaaag agcttcaagg acaactagca gactacaaca tgttggtaga      600

taaacttaat accaacactg aaatggaaga agtaatgaat gattacaata tgcttaaagc      660

tcaaaatgat cgagaaacac aaagtttgga tgtcatattt actgaaagac aagcgaaaga      720

aaaacaaatc agaagtgtcg aagaagaaat tgaacaggaa aaacaagcaa cagatgacat      780

tatcaaaaat atgtcttttg aaaaccaagt caagtaccta gagatgaaaa ccacaaatga      840

gaaactgtta caggaattag atacacttca acaacaattg gattcacaga acatgaaaaa      900

agagagcctg gaagcagaaa tagctcactc ccaggtgaaa caggaggcgg tattgctgca      960

tgaaaaactt tatgagttgg agtcccatcg agatcaaatg attgcagaag acaaaagcat     1020

aggatctcca atggaagaga gagagaaatt acttaagcag attaaagatg ataatcagga     1080

aatagccagc atggaaagac agttaacaga tacaaaagaa aagataaatc agtttattga     1140

agaaattaga caacttgaca tggatttaga ggaacaccaa ggtgaaatga accagaaata     1200

caaggagcta aagaaaaggg aggaacatat ggacactttt attgagactt ttgaggaaac     1260

aaagaatcag gaactgaaac gaaaggcaca gatagaagcc aacattgttg cactcttgga     1320

gcactgcagt cgaaatataa atcgtataga acagatatcc tctatcacca atcaagagct     1380

aaagatgatg caggatgacc tcaattttaa atctactgaa gtgcagaaat cacaaagtac     1440

agctcagaat ttgacttcag acattcaacg tctgcagttg gatctgcaga aaatggagct     1500

tctagaaagt aagatgactg aagaacagca ttctctaaaa agcaaaatta agcaaatgac     1560

aactgatctg gagatatata atgatttgcc agctttaaaa tcatcaggtg aagaaaagat     1620

aaagaaatta catcaggaga gaatgatatt atcaacccac agaaatgcct ttaagaaaat     1680

aatggagaag caaaacatag agtatgaggc actaaaaaca caattgcaag aaaatgagac     1740

acattctcag cttacaaatt tggagagaaa gtggcaacac cttgagcaaa ataattttgc     1800

gatgaaagaa ttcatagcaa ccaagagtca agagagtgat taccagccaa ttaagaaaaa     1860

tgtgaccaag cagattgcag agtacaataa aaccatcgtg gatgctttac atagcaccag     1920

cggaaactga gtttaagtcc actgaaagtc tctaaggaag tatcctcttg ctgctaaact     1980

tggtacaagt tgactaccaa aaaaaaaaaa agcttacttt tggagtttac ctaaaatttc     2040

tgaatgttat aatttttgtg gcctctttta agaatgatat tttaaaatag taaatagttc     2100

aataaatggt ttgcatatt                                                  2119


<210> 3162
<211> 540
<212> DNA
<213> Homo sapiens

<400> 3162
agtgtaacca atcaagcaga atctctaggc gttcgtgctt tgaaatgagg ctccacatag       60

ctcccacgtg ggacaagatg gtgtcttcgg cgcagatggg cttcaacctg caggctctcc      120

tggagcagct cagccaggat gagttgagca agttcaagta tctgatcacg accttctccc      180

tggcacacga gctccagaag atcccccaca aggaggtaga caaggctgat gggaagcaac      240

tggtagaaat cctcaccacc cattgtgaca gctactgggt ggagatggcg agcctccagg      300

tctttgaaaa gatgcaccga atggatctgt ctgagagagc aaaggatgaa gtcagagaag      360

cagctttgaa atcctttaat aaaaggaagc ctctatcatt agggataaca cggaaagaac      420

gaccacctct agacgtggac gaaatgctgg agcgcttcaa aacagaagca caagcgttta      480

cagaaacgaa aggaaatgtc atctgcctgg gtaaagaagt ctttaaagga aaaaagccag      540


<210> 3163
<211> 603
<212> DNA
<213> Homo sapiens

<400> 3163
gtgcaggagc gggacccgga acagaccgcc gtgagagagg aggggtgccg gccgggattc       60

gcggcccgga gctcgggacc ggagaagaag tcctcaccag tgaacggaga cctctctgaa      120

ctaaggatac catggccacg tcagccccac tacggagcct ggaagaggag gtgacctgct      180

ccatctgtct tgattacctg cgggaccctg tgaccattga ctgtggccac gtcttctgcc      240

gcagctgcac cacagacgtc cgccccatct cagggagccg ccccgtctgc ccactctgca      300

agaagccttt taagaaggag aacatccgac ccgtgtggca actggccagc ctggtggaga      360

acattgagcg gctgaaggtg gacaagggca ggcagccggg agaggtgacc cgggagcagc      420

aggatgcaaa gttgtgcgag cgacaccgag agaagctgca ctactactgt gaggacgacg      480

ggaagctgct gtgcgtgatg tgccgggagt cccgggagca caggccccac acggccgtcc      540

tcatggagaa ggccgcccag ccccacaggg aaaaaatcct gaaccacctg agtaccctaa      600

gga                                                                    603


<210> 3164
<211> 460
<212> DNA
<213> Homo sapiens

<400> 3164
acgctgcggg tcctgggccc aggccttggg atgggcggga aggcctggcc gcgccgggct       60

gtgggcactg caggaggccc ctgtgcagat ctcggcccct ttccaaacac tcctgatgcc      120

tcatttgcct ctcgcttctt ttcgaccacc attttggggg ctgaggcact cacggggcct      180

ccccaggttt cactccgttt ctacacagtc ggagccccat ggatctccca tctcccggag      240

gaaccgtgaa gccaaacaga agcgcctgcg agagaagcag gctactctgg aggctgagat      300

agcaggggag agcaagtcac ctgcagaatc cattaaggcc tggaggccta aggagttagt      360

attgtatgaa atccctacga aacccggtga aaagaaagat gtctctgggc ccctgcctcc      420

tgcatacagc ccccgatatg ttgaggctgc ctggtacccg                            460


<210> 3165
<211> 681
<212> DNA
<213> Homo sapiens

<400> 3165
gtacgggagc tggaggctga gcttgatgca gagcagaaga agcacgccga ggcccttaag       60

ggcgtgcgca agcatgagcg ccgtgtcaag gagctcgcat accaggtggg cgacagggtc      120

tccctgggga gtggccctgg agctggccca gcccaagcaa gccctgagtc ccccttgccc      180

gcccaggccg aggaggacag gaagaacctg gctcgcatgc aggacctggt ggacaagctg      240

cagagcaagg tcaagagcta caagcgccag tttgaggagg cggagcagca ggccaacacc      300

aacctggcca agtatcgcaa ggcccagcac gagctggatg atgcggagga gcgggcagac      360

atggcggaaa cccaggccaa caagctgcgg gcacggaccc gggacgccct gggccccaag      420

cacaaggagt gacggcctga ccccctgggc tctaaagagg aatgtctgct gttgcacatc      480

tggctgaggc cacctgcccc gatcctgcca tctctgcatc gccccctgct gccttcagcc      540

ttccctgggc cctgaataaa caccacagcc agtttccttc tcattctttt ctttggggtt      600

caggaggaaa aacacagtcc tagggacaaa agccaggtcc acagcagtca tttttaaaat      660

aaagttattt aatagtctcc a                                                681


<210> 3166
<211> 2296
<212> DNA
<213> Homo sapiens

<400> 3166
agacttgctt caggttccaa cccggtaagg caaatggaga ggctgtcagg agaccagaag       60

tttacctcag ctattgcacc gacgcaccac gtgctctggt gcacatccac cgcctcttcc      120

tgcctcagtt tctccttttg taaaacaaca gcttgtaaag gcctggggat cttctcatcc      180

acgggagttt tctaaggatg caggcgaaag aggatctcac tctgttgcct aggctggaat      240

gtggtggcat gatcacagct cactgcagcc acaaattcct gggctcaagc aatcctcctg      300

cttcagcctc ctgagtagct gggactatag gcaagcgcta ctgtgctcag ctctcactct      360

ctggctgaat gtagaggact ctgaaggctt aggcaagagg ggagttataa ggcaccacag      420

aaccctgaat gactgcatgg agcagaaccc ttcgcaaacc tgctcttcag gcctcctttt      480

tgagacagct ggaaaagatt ctttctcctt ttctagcaat tacttcctcc ctccgactca      540

aatgcctact cagcctctag tattcagtgg ctgctgcagt ttgcggggtt cttctccaga      600

ccatagatgc ctcagttttt gcagtacctg gaggtttcac cagtgaaagc tctgaaacag      660

caaagatggc agcctgccct ttcctctggg agttccatcc taggggtgta cagaactgtt      720

gctggcctga atacacctgc atgaggtggc tgaagactcc agttggatta tttatgagga      780

tggcctgtgc aaaaagacac ccagagattt catgctgttg attcacagaa agcctgttcc      840

tcttcactcc gtagagtcct cagagtctgg atcatccctt acagaagatc cttgataata      900

tttctgatat acctccaagg ttccgtttgt caaatgtgtg cgacccttct gataagtcac      960

cagaggtgat gagggagaga gagaaagaaa gcaaattaca actgtaaaga gtctctgaac     1020

agtgaaagat caaaacagac agtctctggc tttactggat gagtcaccat tgcagcccga     1080

ccgcaaaaac aagcgtggct tctgtactta gcagcagtct tcctgtctgg aaaggaaaca     1140

ttgctcagat tggagatact ggccatttta tagacttcaa agcaacttag gccactgaac     1200

tgtcaggcgg gaaaacaggc tgaagaaatg tcaacaattg ggagttttga aggattccag     1260

gctgtgtctc tgaagcaaga gggagatgac caaccctctg agactgacca cctatcgatg     1320

gaggaagagg acccgatgcc aagacagatt tcaaggcagt caagtgtgac cgaatcaact     1380

ctttacccca atccttatca tcagccttat atctcacgga agtactttgc tacacggccg     1440

ggggccattg agactgccat ggaagacttg aaaggtcacg tagctgagac ttctggagag     1500

accattcaag gcttctggct cttgacaaag atagaccact ggaacaatga gaaggagaga     1560

attctactgg tcacagacaa gactctcttg atctgcaaat acgacttcat catgctgagt     1620

tgtgtgcagc tgcagcggat tcctctgagc gctgtctatc gcatctgcct gggcaagttc     1680

accttccctg ggatgtccct ggacaagaga caaggagaag gccttaggat ctactggggg     1740

agtccggagg agcagtctct tctgtcccgc tggaacccat ggtccactga agttccttat     1800

gctactttca ctgagcatcc tatgaaatac accagtgaga aattccttga aatttgcaag     1860

ttgtctgggt tcatgtctaa gcttgttcca gctatccaga atgcccacaa gaattcaact     1920

ggatctggaa gaggaaagaa actgatggtg ttaactgaac ccattttgat tgagacctac     1980

acagggctga tgtcattcat tggaaaccgc aacaaacttg gctattccct tgcccgtggg     2040

agtattggtt tttgagagtc tttttggtac cataagcata tcatccacag atatgtcact     2100

ttgaaaattc cagtttgacc cacgctattt ttggactgaa acaattaatt atttttaaat     2160

gacgctttat gatttagaaa tttagtattt ccgaaaattt aaaagcttga ttggactgat     2220

agatacacac tttagacctc atacaagaat aatcaaattt tcttaaaact agaaaataaa     2280

tgctgctgag cctatc                                                     2296


<210> 3167
<211> 336
<212> DNA
<213> Homo sapiens

<400> 3167
tctgcgcaag aaccgccggc gggtgtttgg gctgcttgag cggccagtgc tgctgccgcc       60

tgtgtccatt gacactgcca gctacaagat ctttgtgtcc gggaagagtg gtgtgggcaa      120

gacggcgctg gtggccaagc tggctggcct ggaggtgcct gtggtgcacc acgagaccac      180

cggcttgcat ggagaacaca gatgccttcc tcttcctctt ctccttcact gaccgtgcct      240

cctttgaaga cctccctgga cagctggccc gcatagcagg tgaggcccct ggtgtcgtca      300

ggatggtcat cggctccaaa tttgaccagt acatgc                                336


<210> 3168
<211> 3524
<212> DNA
<213> Homo sapiens

<400> 3168
atgggcacag gggattttat ctgcatttcc atgactggag gggcgccctg ggggttcaga       60

ttgcaaggtg gcaaggagca gaagcagccc ttacaagttg caaagattcg aaatcagagc      120

aaagcctctg ggtctgggct ctgtgaggga gatgaagtgg tttccatcaa tggcaaccct      180

tgtgcagatc tcacctaccc tgaagtcatc aagctcatgg aaagcataac agactctctc      240

caaatgctca tcaaaagacc atccagtgga ataagtgagg ctttgatatc tgaaaatgaa      300

aacaaaaacc tcgagcatct cacacatggg ggttatgtgg aaagtaccac cctgcagatt      360

cgaccggcca caaagaccca gtgcacagaa ttcttcctcg cccctgtcaa gactgaagtt      420

cccctagctg agaaccaaag aagtggtccc gactgtgcag gcagcttgaa agaagaaaca      480

ggcccgagct accaaagggc tccccaaatg cctgactccc aaagaggacg cgtggcagaa      540

gagctgatct taagggagaa ggtagaagcg gtacagcctg ggcctgtggt tgagctgcaa      600

ctgtcccttt cacaggagag acataagggc gctagtggcc ctttagtggc tctcccggga      660

gctgaaaaat ctaagtctcc tgacccagac cctaacttgt cacatgacag gattgtccac      720

ataaattcga tccctactaa tgagaaagca gaccctttcc tgaggtccag caagataatc      780

cagatctcca gtggcagaga gttgagagtg atccaggaaa gtgaagcagg agatgcggga      840

ctgccccggg tggaagtgat cctcgactgc tctgacaggc agaagacaga agggtgcagg      900

cttcaggcag gaaaggagtg tgtggattct ccagtggaag gagggcagtc agaagcacct      960

ccttctctgg tatcctttgc cgtctcatca gaaggcacag agcagggaga agatccacgc     1020

tcggaaaaag atcacagcag acctcacaag caccgagcgc ggcatgcacg gctcaggagg     1080

agtgaaagcc tgtcagaaaa acaagtgaag gaagcaaaat ctaaatgcaa aagcattgcc     1140

cttcttctaa cggatgctcc caaccccaac tccaaggggg tgttgatgtt taagaagcga     1200

cgtcggaggg ccaggaaata caccctagtt agctacggta ctggcgagct tgagcgagag     1260

gcggacgagg aggaagaagg tgacaaggag gatacatgtg aagtagcatt tcttggtgca     1320

agcgaatcag aggtggatga agagttattg tctgacgttg acgacaacac acaagttgtg     1380

aactttgact gggattctgg actggtggac attgaaaaga aactgaacag aggggacaag     1440

atggagatgt taccagacac cacaggcaag ggagccctca tgtttgccaa gaggagggag     1500

agaatggatc agatcacagc ccaaaaagaa gaggacaagg taggtggaac gccaagcaga     1560

gaacaagatg ctgcccagac cgatggcctg agaaccacga cttcttacca aagaaaggag     1620

gaagagtcgg taagaacgca gagctctgtg agcaaaagct acatcgaggt gagtcatggt     1680

cttggccatg ttccccaaca gaatggcttc agtgggacat ctgagacagc aaacatccag     1740

aggatggtcc ccatgaatag aacggccaaa cccttcccag ggtctgtgaa tcagccagct     1800

acccccttct cgccaacccg aaacatgacg agtcccattg ctgactttcc tgcacctcca     1860

ccttactctg cagtcactcc tccccctgac gccttctcca gaggggtttc aagtccgatt     1920

gctggcccag cacagccccc tccatggccc cagcctgccc cgtggtccca gccagccttt     1980

tacgattcgt ctgagcgaat agcttcccga gatgagagga tctcagtgcc agcaaaaaga     2040

acaggaatat tgcaggaggc caaaaggaga agcacgacaa aacccatgtt tacttttaaa     2100

gagcccaaag taagcccaaa tcctgaactc ttgtcactcc ttcaaaattc agaaggcaaa     2160

cggggcactg gagctggagg tgattccgga ccggaagaag actacctcag cttgggggca     2220

gaggcttgta atttcatgca aagctcctct gccaaacaaa agacccctcc tcctgttgct     2280

ccaaaacctg cagtcaagtc ctcatcctcc caaccagtaa ctccagtttc cccagtctgg     2340

tctccaggag tggctcccac ccaacctcct gccttcccca catccaaccc atcaaagggc     2400

accgttgtct cctccatcaa aatagcccag ccttcttacc ctcctgcccg gcctgcaagt     2460

actttgaacg tggctggtcc cttcaaagga ccacaagcag cagtagccag tcagaattac     2520

acacccaaac caacagtttc cacaccaaca gtcaatgctg ttcagcctgg tgcagtggga     2580

ccatccaatg agcttccagg aatgagtggg agaggagctc agctctttgc taaaaggcag     2640

tcgagaatgg agaagtatgt ggtcgattca gacacggtgc aggcccacgc tgctcgagct     2700

cagtctccca ctccatctct cccggccagt tggaagtact cctccaatgt ccgagcacct     2760

cctcctgtgg cctataatcc tatccactcg ccgtcttacc cactggctgc tctcaagtct     2820

cagccatcag ctgcacagcc ctccaaaatg ggcaagaaaa agggaaagaa acccctcaat     2880

gcattagatg tcatgaagca ccaaccgtat cagctcaatg catccttgtt tactttccaa     2940

cctccagatg caaaggatgg cctcccccag aagtcatcag tcaaggtcaa ttcagccctg     3000

gccatgaagc aagctcttcc tccccggcca gtgaatgctg cctcacctac gaatgtgcag     3060

gcttcgtcag tgtactcggt accagcctat acctctcctc cttccttctt tgcagaggcc     3120

tcctcaccag tcagtgcatc cccagtgcct gtgggcattc ccacctcgcc aaagcaagaa     3180

tcagcctcat catcttattt tgtggcacca aggccaaagt tctcagccaa gaaaagtggt     3240

gtcacaattc aggtgaaatg taaatctggg atccatagtc aagatatcat aaggacctac     3300

ttcccagcct acctttcttc ctctacctga taatgataat actcaaaata acaacattca     3360

aaggaaacac aaagaaatcc tgctttcaca tctcctattt cttgggctcc ttaataacta     3420

ctgatggttt gttcatgaaa aaaaattttt aaatcaaaag attgtacttg gccctgagtt     3480

gaaaaaattt caaaaatcaa aagtttgtac ttggccctga gttg                      3524


<210> 3169
<211> 4728
<212> DNA
<213> Homo sapiens

<400> 3169
actgccgctg ccgcggctac ctgcggttca tctccgcaca ttccacacgc ggcccaaacg       60

gtctctctct ctctctctca aacaccgcct ttccgtcttt gttttatctt gagtagctta      120

gaaagattgg agaagaaagc ttacgtggaa tgaaaatcaa cttttatgga tattttgagg      180

actaaaagaa taaatagggc gtccgtactg tagcgaaagt gcgactaagg ttaggcatct      240

ggatttcccc cgtagccctc tttcaccccc cccccccggc cattaccgaa gcggatgaaa      300

acaaacacta acgatggcgg cgccgggaag cgaccggctg ctgggcttaa ggcgggagtg      360

accgcttaac cagtgaggga agcactgaag agcgccagtc gacgtgggtg cgacaactcg      420

cggagtctta ggagcaaaac gtctggggcc tgcgagccag gacccttctg aagccttagg      480

tgtctatcgg cgacgtgtac ggtcactgca gctccggagc gcggaaccct cagccaggag      540

gcgcggctgg tcggtcccag gtcccggcct ccgtaatgag agcccggaac cactctttgt      600

gccgcagctt cgcaggtact aacttttgcg ggggataccc caagatctct cagcgccccc      660

gggtgggagg ctgtggattc ctataggcaa tggaaactga tctcaattcc caggacagaa      720

aggacctgga caagtttatt aaattttttg ccctcaagac tgtccaagtg attgtccagg      780

ctcggcttgg tgaaaagatt tgcactcgtt catcatcttc tccaacgggt tcagattggt      840

tcaacttagc aatcaaagac atcccagagg ttacacatga agcaaagaag gcactggcag      900

gacagctgcc tgcagtcggg aggtccatgt gtgtggagat ttcacttaag acttctgagg      960

gagattccat ggagctggaa atatggtgtc ttgaaatgaa tgaaaagtgt gataaagaaa     1020

tcaaagtttc ctacacggtg tacaacagac tgtcattgct gctgaagtcc cttcttgcta     1080

taactagggt gacaccagcc tataggctct ccaggaaaca agggcatgaa tatgtcatat     1140

tatacaggat atattttgga gaagttcagc tgagtggctt aggagaaggc ttccagacag     1200

ttcgtgttgg gacagtgggc acccctgtgg gcaccatcac tctttcttgt gcttacagaa     1260

ttaacttggc attcatgtct accaggcaat ttgagaggac cccacctatc atggggatta     1320

ttattgatca ctttgtggac cgtccctatc ccagctcctc tcccatgcac ccctgcaatt     1380

acagaactgc tggtgaggac actggagtaa tatacccgtc tgtagaagac tctcaagaag     1440

tgtgtaccac ctctttttcc acctccccac catcccagct ctcaagctct cgcctttcct     1500

atcagcctgc tgccctgggc gttggatcag ctgacctggc ttatccagta gtgtttgctg     1560

ctggcttaaa tgctacacac cctcaccagc tgatggttcc tgggaaggaa ggtggggtac     1620

cccttgctcc caaccagcct gtccatggta cccaggctga ccaggagaga ctggcaacct     1680

gcaccccttc tgacagaacc cactgtgctg ccacaccctc cagtagtgag gatactgaaa     1740

ccgtatcaaa cagcagtgag ggacgggcct cccctcacga tgtcttggag accatctttg     1800

tccgaaaagt gggggctttt gtcaacaaac ccattaacca ggtgaccctg acgagtttgg     1860

atataccctt tgccatgttt gctcccaaga atttggagct ggaggatacc gatccaatgg     1920

tgaatcctcc agattcccca gagactgaat ctcctctcca gggcagcctg cactcagatg     1980

gctccagcgg gggcagcagt ggcaataccc atgatgactt tgttatgata gactttaaac     2040

cagctttttc taaagatgac attcttccga tggacctggg gaccttctat cgggagtttc     2100

agaacccacc tcagctgagc agcctctcca tagatattgg agcacagtcc atggctgaag     2160

acttggactc attaccagag aagctggctg tgcatgagaa gaatgtccgc gagtttgatg     2220

cctttgtgga aaccctgcag taaaagtatc cttgagtccc agcagcaccc cctttttgtg     2280

gccccagggc ataagcagcc tcccatgcat cagctgctcc cacccctcat cctgctctga     2340

gccaggtgga agggaggctg gcttctccca tggggaccca gaagtcccta ctcttggacc     2400

tcctggagac tccgtggcgg cagtcaagcc cagtgcccag ttggagaaga ctcacgtgct     2460

ggccttggag atgggaagaa ccttcgtacg aaaaagccct cagcagggcc atctgtgtgc     2520

cctgcccatc accaactgct tcccaagggt gtcatcctgt tcctcctgct gccggcctcc     2580

tgcctgggcc tgccttgcag ctggcccctt ccctgcctgc tgtcaccatc cactgtttga     2640

cattccagct ggtggccaag agattggtgt ggagtcgcag aaagaggaag gagacagtgc     2700

caggaggaag aaggaaggag tcccttagct ctcttcattg tcccctttac ttcctgctat     2760

cttcttctcc tcttcttctc tctcttgcct ctatgcctgt atttctggca atatgacagg     2820

cctgcctacc caagatcaga actccaaaac cactcccacc cctgaaggtc gggagggtct     2880

gagcagccct ggtggctgcc tgtgctcagg tcctcagctc catgggaaat aaaaatggca     2940

ccctgaatct ctaggatttt gtcacttgga gtcacagcaa agttctcttc ctcttgtccc     3000

cccgttgctg ctccttggtt atagaacatg gtaaatattt attactttca gagaaaccag     3060

atattttata gaggaaatat gtttgaggtg agttgttttt cacttggaga aggcggaggg     3120

ctcttcctgg gacggagacc tcctcctccg gaggttattg agaatccggg ctgctgcttt     3180

gaggatcttc ccaccataca gacagcgaga tccaagaaga gggctggccg ggggcaaagt     3240

cacctcccag tgtggctgca ctggaactga ctaaaggctt taccttggat agttgcgtat     3300

tcctggtgag agccttacat ctcccacagt ttctgcagag tgactgactc cattctggca     3360

gcccaggaag tcctgggtgc taaatgtgat ggccacatgt agtggttagg ggatgttgtg     3420

tgtgtccccc aactgcctgg gtacttgttc ctgatccctg gggctgtcct gtggagcttt     3480

tcctcctgct tgggcctagc taccatctcc ctctaatccc aggttctcta cactgccctg     3540

gggtttacca gctggattgg cttctggttg agaaatcaaa gctgggcgta tgattgactt     3600

aacccttcag gtattgttac ttgaataagt caagtgccta gcctcaccca cctatgatct     3660

gtcctttccc agcctcgctg gtagtcctgg tcaaggagat ctaggtctac tccattcctc     3720

ctggcccacc tggggcattc actggcagca gctgtgcttc agtggagcag gtggttctca     3780

gctgcttgtt agtatactgc atgtgacact gttcccacat acaaggctga cttctgagga     3840

ttggagcagg ctctggcggg gaccagagct ctgcgtgctg ctgctgccac caagaagtgt     3900

tagcagaagc agtagcagcc aactggccct cctgactttg gcccagagca catgcgtggc     3960

ttgctgaacc caggctcagg tttatcccca aggccccagc tttgagaagg gggaaggccc     4020

ctggtaagtt attgatgccc ccatatttca gctactgctc tctttccaag gccttgcatg     4080

gaaaggccta gccattgtct gaggcagcaa tctttggcat ctacaggtgg cagcagcctt     4140

tcaccagggc tccatctgtg aagagtctca gccatgactt tgagctgagc ttgggagaag     4200

taaagcaact gttaaggcca gcccttgccc ctcagacctg ccatgaaagg aatgagccct     4260

agactgactc ctgcagcacc cccgggacag gctgggacca gctgtttgtc tccaggtgtc     4320

agagtccctc ctcctcctcc aacctctcca acctactttg tttggaaata ccgagctaca     4380

cttcaaaatg tattcaaggg atttccaata aatttttttc tgtactttac agcctcctgt     4440

cctgtaggtt gtctgaagac ctcgtaaccc cttccccacc cctgccccag tgcaggtctg     4500

ggaaagggga gagtggtgcg ttgtgaagcg cagaaagacc tcaagtgtct gggcaagcct     4560

gttttgagtc gggtgtggcc tcttaggggc tgtataccct ggggtttcct gggtcaggaa     4620

acttcttagt atttctcttt ccctggtccc ctatcagggg cttgaatttg aatattcagt     4680

tggagaatgc atttaaaata cacccatagt aaaatctcca taaaatgc                  4728


<210> 3170
<211> 460
<212> DNA
<213> Homo sapiens

<400> 3170
acgctgcggg tcctgggccc aggccttggg atgggcggga aggcttggcc gcgccgggct       60

gtgggcactg caggaggccc ctgtgcagat ctcggcccct ttccaaacac tcctgatgcc      120

tcatttgcct ctcgcctctt ttcgaccacc attttggggg ctgaggcact cacggggcct      180

ccccaggttt cactccgttt ctacacagtc ggagccccat ggatctccca tctcccggag      240

gaaccgtgaa gccaaacaga agcgcctgcg agagaagcag gcgactctgg aggctgagat      300

agcaggggag agcaagtcac ctgcagaatc cattaaggcc tggaggccta aggagttagt      360

attgtatgaa atccctacga aacccggtga aaagaaagat gtctctgggc ccctgcctcc      420

tgcatacagc ccccgatatg ttgaggctgc ctggtacccg                            460


<210> 3171
<211> 1199
<212> DNA
<213> Homo sapiens

<400> 3171
gctttgcaag ttcttcaccg caaagaactg ccgcagactt ccgcctgggt gccaaccacg       60

tgatcacgcg agcgttggag aggccctaaa ttatacagat ctgtgattga agatgtcatt      120

aatgatgtga gagacatctt tctggatgat ggagtggatg aacaagtact gatggaacta      180

aaaactttat gggaaaacaa actaatgcag tccagggcag tagatggatt tcattcagaa      240

gagcagcagc ttctactgca agttcaacag cagcatcaac cccagcagca gcagcatcac      300

caccatcacc atcatcagca agctcagcct cagcagacag tacctcagca agcgcagacc      360

cagcaggttc ttattcctgc atcacagcaa gccacagcac cacaagttat tgttccagat      420

tctaagttga tacagcatat gaatgcatca aacatgagtg ctgctgctac agctgctacc      480

ttagcactcc ctgcaggtgt gactcctgtt cagcagatat taacaaattc aggccagctt      540

cttcaggtgg tcagagcagc caatggtgcc caatatatct ttcagcctca gcagtcagtg      600

gttctacaac aacaggttat accacaaatg cagcctggtg gagtacaagc tcctgttata      660

cagcaggtgc tggctcctct tcctggaggg atttcaccac agacaggtgt catcatccag      720

cctcagcaaa tcttatttac aggaaataag actcaagtta tacctacgac agtggcagca      780

cctacaccag cccaagcaca gataactgca actggccagc agcaaccgca ggcccagcct      840

gctcaaacac aagctccatt ggtcttacaa gttgatggaa ctggggatac atcatctgaa      900

gaagatgaag atgaagaaga agactatgat gatgatgagg aggaagacaa agagaaagat      960

ggagctgaag atgggcaggt ggaagaagag cccctcaata gtgaagatga tgtgagtgat     1020

gaggaaggac aggaactctt tgacacagaa aatgttgttg tatgccaata tgataagata     1080

cacagaagta aaaacaaatg gaaatttcat ctcaaggatg gcattatgaa tcttaatgga     1140

agagattata tattttccaa agccattgga gatgcagaat ggtgaagagt tgctttttt      1199


<210> 3172
<211> 5584
<212> DNA
<213> Homo sapiens

<400> 3172
gtcgtgctct cctcggtagg ggaggaattg gttaggcggc ggcggcggcg aagcggcggc       60

ggcggctgta ggggagcagc ggcagtggcg gcgacggcga ggaggtgttc ggtttgcgca      120

gcgtagaaac gcccgcagct tcagagaagg agttcttgtg ggaccaaatt aggcattctg      180

aacccacgcc ggcttagctg ggccgagtcc aggcgctgcc gcacgtacag ttttggtggc      240

ggtgacagac actgttcttg actctagggg cctattaggc cgacgtctga ggcgcagatc      300

gctggctctc gacgcattac tctttacgcc ttacatttct gtcttccttc ctgggtcagt      360

gattcccgga ccctggaaga gaagagggtg gctaatgatt aaggctttcc ttaaagtttc      420

ccatgtctca atggactcct gaatataacg agctctacac cttaaaagtg gatatgaaga      480

gtgagattcc ttctgatgca ccaaagacac aggagagtct gaaagggatc cttttgcatc      540

cagagcccat tggggcagcc aaaagttttc ctgcaggagt tgagatgatt aatagtaaag      600

tggggaatga attctctcac ctgtgtgatg attctcaaaa gcaagagaag gaaatgaatg      660

gtaaccagca agaacaagaa aaaagtctcg ttgtgaggaa aaaacgcaaa agccagcagg      720

ctggcccttc gtatgtgcag aattgtgtta aagaaaacca gggaatatta ggactgaggc      780

aacacctagg gacaccaagt gatgaagata atgattcctc ttttagtgat tgtctttctt      840

ctccttcatc tagtctgcat tttggagatt ctgatactgt gacttcagat gaggataaag      900

aagtctctgt aagacattcc cagaccattt tgaatgctaa aagtagaagc catagtgcac      960

ggtctcataa gtggcctcgg actgagacag aatctgtatc gggattgtta atgaaaagac     1020

cctgtttaca tggcagttcg ttacggagac ttccatgcag aaagagattt gtaaaaaata     1080

attcctcaca gaggacacag aaacaaaaag agaggatatt aatgcagagg aagaaacgag     1140

aagtgttagc tcgaagaaaa tatgccttgc tacctagttc tagtagttcc agtgagaatg     1200

acctcagcag tgaatcctct tctagctcat caactgaagg agaagaagat ttgtttgttt     1260

ctgccagtga aaaccaccaa aacaatccag ctgttccctc aggaagtatt gatgaagatg     1320

ttgtggtgat agaagcttcc tccactcccc aggttactgc caatgaagaa attaatgtta     1380

cctcaactga cagtgaagtg gagattgtaa cagttggaga aagctatcgg tctcgttcaa     1440

cccttggaca ctccagatct cattggagcc agggttccag ttctcatgca agtcggccac     1500

aggagccacg gaaccgcagt aggatttcta ctgttataca gcccttgagg cagaatgcag     1560

cagaagttgt ggaccttacc gttgatgaag atgaacctac tgtagtacca accacttctg     1620

caagaatgga atcacaagct actagcgctt ccattaacaa ttcaaatcca tctacctctg     1680

agcaggcctc tgatactgct tcagctgtca ccagtagcca accttccaca gtgtcagaga     1740

cttcagctac tcttacaagc aatagtacca ctggcacttc tataggagat gactcaagga     1800

gaactacatc tagtgctgta acggaaactg gccctcctgc aatgccaagg ttaccttcct     1860

gctgtcccca gcactcacca tgtggagggt cgtcacagaa ccaccatgca ttaggacatc     1920

ctcatacaag ttgctttcag cagcatggtc accattttca acatcatcac caccaccacc     1980

atactcccca cccagctgtc ccagtttctc cttcctttag tgatcctgct tgccctgtgg     2040

aaagacctcc acaagtacaa gcaccttgtg gagcaaatag tagttctggt accagctatc     2100

atgaacagca ggcattgcca gtggacctga gcaacagtgg tatcagaagt catggaagtg     2160

gcagttttca tggagcatct gcatttgacc cctgctgccc tgtttcttcc tcccgagctg     2220

caatctttgg ccatcaggcc gctgctgctg ccccaagtca acctttatca tcaatagatg     2280

gctatggatc aagcatggtt gcgcagcccc agccccagcc ccctccacag ccctctctct     2340

catcatgtcg acattacatg ccaccccctt atgcctcttt gacaaggcca cttcatcatc     2400

aagcttctgc ctgcccgcat tctcatggaa acccccctcc tcagactcag cctccgcctc     2460

aagtggatta tgttattcct catcctgtac atgctttcca ttctcaaata tcttctcatg     2520

caacatctca tcctgtggca cccccaccac caactcactt agccagtaca gctgcaccaa     2580

tccctcagca tcttcctcct acacaccagc caatttcgca ccatattcca gccacagcac     2640

ctccagcaca gagactgcat cctcatgaag tgatgcagag gatggaagtt caaaggagga     2700

ggatgatgca gcatccaact ggtctttttg tgttctgtgt ttccaggcgg gcacatgaac     2760

gccccccacc ccatccacat aggatgcacc caaactatgg tcatgggcat catattcatg     2820

tgcctcagac tatgtcctca catcctcgac aggctccaga gaggtctgcc tgggaactgg     2880

gaattgaagc tggagtgact gcagctactt atacacctgg tgcattgcat cctcacttgg     2940

cccattatca cgcacctcct cgacttcatc acttacaatt aggagctctt cctttaatgg     3000

ttcctgatat ggcaggctat cctcacatcc gttacatttc atcaggattg gatggaacat     3060

cattcagagg tcctttcagg ggcaattttg aggaactgat tcatttggaa gaaagattag     3120

gcaatgtcaa tcgtggagca tcccagggga caattgaaag atgtacatat ccacataaat     3180

acaaaaaggt aacaactgat tggttctcac agaggaaact gcactgcaaa caagatgggg     3240

aagaagggac tgaggaagac acagaggaaa aatgtactat ctgtttgtct attttagagg     3300

aaggtgaaga tgtgagacgt cttccatgta tgcacctttt ccaccaagtg tgtgttgacc     3360

aatggttgat taccaataag aagtgcccca tatgcagagt ggacattgag gcccagctgc     3420

caagtgaaag ttgacaccat gtttcagaac tcttgccctc cctctcattc ccatccttcc     3480

tggtactgca gtcaaccaaa gatggcatga cttacctgcg cagatttgga agcattgaac     3540

ttagagtgct ggctctgcta tatggtacaa ctaatgctag acctacagtt tatgtataca     3600

gttgattttg atgtatttat aaaagctttt ttttctagat ttgacatttt tctgtatcat     3660

tttactgtat ttttgcatgg ttccttgtat tgcatttctt tgcacatatt atgggcttgt     3720

gaccctaaac ttgcaggcaa ggttagctgc tttagtaagt agaattttgt ggtctttttg     3780

ttttttacat agtaccaagc cttgataatt atgaattttt tatccattac taacctttaa     3840

tttaatcaat catgtacttt agtttaatgt ataaagatcc tctagaaaat gataatattg     3900

tgtattaaga cattccttaa ttaggacaaa atggctgctg tatatttact atatggagtt     3960

ctgagttaaa taccatcctt aatactggga acagaataca acccatataa atcagatgca     4020

ggtggtagtc acatcaccag agtgatcagt ataaattttc ttggtgtatc cttttccttt     4080

caacacagtg cagataagag ttgaatattg atatcataca tttagactgc tgttctgatt     4140

gcatttatct ttttcctaca tcatttagaa ttttatttcc ctgattcagt ttttgctgct     4200

gtgaaacagc tctgatgaac actaaatatt aatttcaatt agctagattg tacatacttg     4260

cagatttaac aaaattttag ggaaattgaa aaagacatgt agaatttgtt gtcttctgct     4320

aagcacgaaa agttaagata tctgcttaca ttgattttgt agacacatta agtcaagatt     4380

tggaatttaa gtcactggca ggtatctgtg cattcataga acttataaag gtcccaggat     4440

cacttttaag ggatttttat tagtttaaag gtaaataaag tcagctgaat ctacatgtct     4500

cttgttttat ttctctctaa acttgaaaac agtaaatctg cagatactgt gaggcacaaa     4560

ttatactgtc aacctactgt tgctatggtt atatactccc acttcataca ttaccaagag     4620

tcgatcactg atttaaaatt tttaatttct atagttaaga tttactgcat aatatagaat     4680

ataaagttaa gttaacatac taacatttct cctttggagg aagttttaat ctacttcagg     4740

atgcatatta ttatcaagat actttcatat acaggatagc ctaattttat ttgtttaaat     4800

atgcttaata tgccccagat tgcaaatgca tccagtcagt aatatcactg tctgtatgtg     4860

gaggacatgt tcccatggat catatgtgaa gatgtcaata agcttgcatt aagccacctg     4920

ctttgtaagt ggattgatta ataaataact tatatttcta ttgtctttgt gtttcataat     4980

tagtttttat aaaaacagtt tacattaaac atcttggaat tcaacaatag tgatctcact     5040

caaattgaca tttgcataat ttgacattta tattcattca gttatgacta cttgcccttt     5100

tcttcatatt agtaaatgtt acactgtagt agttgtcaat gttaacaggc ttcaacatag     5160

tatgtgtgca gatggacgat ggatttaaag agcatacctt atgattaaac cgaggttata     5220

gaaggtcagg ggagagtgaa ggagtcagtg acctatgtct gccatcttac tggggaaaag     5280

agcaagtagc ctgtcttcct ttaagtaagt agcctgtaat ggatgtacta ctttgccact     5340

ggaatacccc gggtctgtgc caagggactg aagaagtgta agatggggag aactgtatgt     5400

catggagtcc tcttgacgtt cccccagata caagtaaagc acaggtggat ttctctattt     5460

ttgaatacta catcagattt agatgcacga ctacctgttg acttgtttta taattgctac     5520

tgattttttt aatgtaggca aagctttgtt actttgaaat ttatttaata aaagtatttg     5580

tgac                                                                  5584


<210> 3173
<211> 3818
<212> DNA
<213> Homo sapiens

<400> 3173
cgtcccccag ccccggcctc ccgcggaccc atgcccgccc gtatcggcta ctacgagatc       60

gaccgcacca tcggcaaggg caacttcgcg gtggtcaagc gggccacgca cctcgtcacc      120

aaggccaagg ttgctatcaa gatcatagat aagacccagc tggatgaaga aaacttgaag      180

aagattttcc gggaagttca aattatgaag atgctttgcc acccccatat catcaggctc      240

taccaggtta tggagacaga acggatgatt tatctggtga cagaatatgc tagtggaggg      300

gaaatatttg gaggatttgg acatcagcaa ttctcattct gccccgagct gcctattgct      360

gagtcctgga gaagtgcagt taagagatgg gggccccttc ttctactcag cccccacttg      420

tggaacttga tcagaccacc tggtggccca tggtagaatg gcagaaaagg aggcacgtcg      480

gaagttcaaa cagatcgtca cagctgtcta tttttgtcac tgtcggaaca ttgttcatcg      540

tgatttaaaa gctgaaaatt tacttctgga tgccaatctg aatatcaaaa tagcagattt      600

tggtttcagt aacctcttca ctcctgggca gctgctgaag acctggtgtg gcagccctcc      660

ctatgctgca cctgaactct ttgaaggaaa agaatatgat gggcccaaag tggacatctg      720

gagccttgga gttgtcctct acgtgcttgt gtgcggtgcc ctgccatttg atggaagcac      780

actgcagaat ctgcgggccc gcgtgctgag tggaaagttc cgcatcccat tttttatgtc      840

cacagaatgt gagcatttga tccgccatat gttggtgtta gatcccaata agcgcctctc      900

catggagcag atctgcaagc acaagtggat gaagctaggg gacgccgatc ccaactttga      960

caggttaata gctgaatgcc aacaactaaa ggaagaaaga caggtggacc ccctgaatga     1020

ggatgtcctc ttggccatgg aggacatggg actggacaaa gaacagacac tgcagtcatt     1080

aagatcagat gcctatgatc actatagtgc aatctacagc ctgctgtgtg atcgacataa     1140

gagacataaa accctgcgtc tcggagcact tcctagcatg ccccgagccc tggcctttca     1200

agcaccagtc aatatccagg cggagcaggc aggtactgct atgaacatca gcgttcccca     1260

ggtgcagctg atcaacccag agaaccaaat tgtggagccg gatgggacac tgaatttgga     1320

cagtgatgag ggtgaagagc cttcccctga agcattggtg cgctatttgt caatgaggag     1380

gcacacagtg ggtgtggctg acccacgcac ggaagttatg gaagatctgc agaagctcct     1440

acctggcttt cctggagtca acccccaggc tccattcctg caggtggccc ctaatgtgaa     1500

cttcatgcac aacctgttgc ctatgcaaaa cttgcaacca accgggcaac ttgagtacaa     1560

ggagcagtct ctcctacagc cgcccacgct acagctgttg aatggaatgg gcccccttgg     1620

ccggagggca tcagatggag gagccaacat ccaactgcat gcccagcagc tgctgaagcg     1680

cccacgggga ccctctccgc ttgtcaccat gacaccagca gtgccagcag ttacccctgt     1740

ggacgaggag agctcagacg gggagccaga ccaggaagct gtgcagagct ctacctacaa     1800

ggactccaac actctgcacc tccctacgga gcgtttctcc cctgtgcgcc ggttctcaga     1860

tggggctgcg agcatccagg ccttcaaagc tcacctggaa aaaatgggca acaacagcag     1920

catcaaacag ctgcagcagg agtgtgagca gctgcagaag atgtacgggg ggcagattga     1980

tgaaagaacc ctggagaaga cccagcagca gcatatgtta taccagcagg agcagcacca     2040

tcaaattctc cagcaacaaa ttcaagactc tatctgtcct cctcagccat ctccacctct     2100

tcaggctgca tgtgaaaatc agccagccct ccttacccat cagctccaga ggttaaggat     2160

tcagccttca agcccacccc ccaaccaccc caacaaccat ctcttcaggc agcccagtaa     2220

tagtcctccc cccatgagca gtgccatgat ccagcctcac ggggctgcat cttcttccca     2280

gtttcaaggc ttaccttccc gcagtgcaat ctttcagcag caacctgaga actgttcctc     2340

tcctcccaac gtggcactaa cctgcttggg tatgcagcag cctgctcagt cacagcaggt     2400

caccatccaa gtccaagagc ctgttgacat gctcagcaac atgccaggca cagctgcagg     2460

ctccagtggg cgcggcatct ccatcagccc cagtgctggt cagatgcaga tgcagcaccg     2520

taccaacctg atggccaccc tcagctatgg gcaccgtccc ttgtccaagc agctgagtgc     2580

tgacagtgca gaggctcaca gtgcacatca gcagccgcca cactatacca cgtcggcact     2640

acagcaggcc ctgctgtctc ccacgccgcc agactataca agacaccagc aggtacccca     2700

catccttcaa ggactgcttt ctccccggca ttcgctcacc ggccactcgg acatccggct     2760

gcccccaaca gagtttgcac agctcattaa aaggcagcag caacaacggc agcagcagca     2820

gcaacagcag caacagcaag aataccagga actgttcagg cacatgaacc aaggggatgc     2880

ggggagtctg gctcccagcc ttgggggaca gagcatgaca gagcgccagg ctttatctta     2940

tcaaaatgct gactcttatc accatcacac cagcccccag catctgctac aaatcagggc     3000

acaagaatgt gtctcacagg cttcctcacc caccccgccc cacgggtatg ctcaccagcc     3060

ggcactgatg cattcagaga gcatggagga ggactgctcg tgtgaggggg ccaaggatgg     3120

cttccaagac agtaagagtt caagtacatt gaccaaaggt tgccatgaca gccctctgct     3180

cttgagtacc ggtggacctg gggaccctga atctttgcta ggaactgtga gtcatgccca     3240

agaattgggg atacatccct atggtcatca gccaactgct gcattcagta aaaataaggt     3300

gcccagcaga gagcctgtca tagggaactg catggataga agttctccag gacaagcagt     3360

ggagctgccg gatcacaatg ggctcgggta cccagcacgc ccctccgtcc atgagcacca     3420

caggccccgg gccctccaga gacaccacac gatccagaac agcgacgatg cttatgtaca     3480

gctggataac ttgccaggaa tgagtctcgt ggctgggaaa gcacttagct ctgcccggat     3540

gtcggatgca gttctcagtc agtcttcgct catgggcagc cagcagtttc aggatgggga     3600

aaatgaggaa tgtggggcaa gcctgggagg tcatgagcac ccagacctga gtgatggcag     3660

ccagcattta aactcctctt gctatccatc tacgtgtatt acagacattc tgctcagcta     3720

caagcacccc gaagtctcct tcagcatgga gcaggcaggc gtgtaacaag aaacagagag     3780

ttttgtgtac agcttgggaa tgaaaaggtt gattgtaa                             3818


<210> 3174
<211> 1896
<212> DNA
<213> Homo sapiens

<400> 3174
atcagaccat tgagatgtgg aagctgttgc tgtgggttgg tgctgcccat aaactcgtgt       60

gttatttcac caactgggca cacagtcggc caggccctgc ctcgatcttg ccccatgacc      120

tggacccctt tctctgcacc cacctgatat ttgcctttgc ctcaatgaac aacaatcaga      180

ttgttgctaa ggatctccag gatgagaaaa ttctctaccc agagttcaac aaactaaagg      240

agaggaacag agagctgaaa acactactgt ccatcggcgg gtggaacttt ggcacctcaa      300

gattcaccac tatgttgtcc acatttgcca accgtgaaaa gtttattgct tcagttatat      360

cccttctgag gacacatgac tttgatggtc ttgacctttt cttcttatat cctggatttc      420

atcaatgtct tgtcttatga cttacatgga agttgggaaa ggttcacagg acataatagc      480

cccctcttct ctctgcctga agaccccaaa tcttcggcat atgctatgaa ttattggaga      540

aagcttgggg caccctcaga gaagctcatc atggggatcc ccacctatgg acgtaccttt      600

cgcctcctca aagcctctaa gaatgggttg caggccagag cgatcggacc agcatctcca      660

gggaagtaca ccaagcaaga aggcttcttg gcttattttg agatttgttc ctttgtctgg      720

ggagcgaaga agcactggat tgattaccag tatgtcccgt atgccaacaa ggggaaagag      780

tgggttggct atgacaatgc catcagcttc agttacaagg catggtttat aaggcgagag      840

cattttgggg gggccatggt gtggacattg gacatggatg acgtcagggg cacgttctgt      900

ggcactggcc ctttccccct tgtctacgta ttgaatgata tcctggtgcg ggctgagttc      960

agttcaactt ctttaccaca attttggctg tcatctgctg tgaattcttc aagcactgac     1020

cctgaaaggc tggctgtgac cacggcatgg accactgata gtaagatttt gcccccagga     1080

ggagaggctg gggtcactga gatccacgga aagtgtgaaa atatgactat aacccctaga     1140

ggtacaactg tgacccctac aaaggaaact gtatcccttg gaaagcacac tgtagctcta     1200

ggagagaaga ctgagatcac tggggcaatg accatgactt ctgtgggtca tcagtccatg     1260

acccctggag agaaggccct gacccctgtg ggtcatcaat ctgtgaccac tggacagaag     1320

accctgacct ctgtgggtta tcagtctgtg acccctgggg aaaagaccct gacccctgtg     1380

ggtcatcagt ctgtgacccc tgtgagtcat cagtctgtga gccctggagg aacgactatg     1440

acccctgtcc attttcagac tgagaccctt agacagaata cagtggcccc tagaaggaag     1500

gctgtggccc gtgaaaaggt gactgtcccc tccagaaaca tatcagtcac ccctgaaggg     1560

cagactatgc ctttaagagg ggagaatttg acttctgagg tgggcactca ccccaggatg     1620

ggtaacttgg gtcttcagat ggaagctgaa aacaggatga tgctgtcctc cagccccgtc     1680

atccagctcc cggaacaaac tcctctagct tttgacaacc gctttgttcc catctatgga     1740

aaccattcct ctgtcaactc agtaacccct caaacaagtc ctctttctct aaaaaaagaa     1800

atcccagaaa actctgctgt ggatgaagaa gcctaagccc ctctggtgtc agaaaccagg     1860

gaaaaccctt gtcttttctt ctaagtgaca tgttgg                               1896


<210> 3175
<211> 1572
<212> DNA
<213> Homo sapiens

<400> 3175
ctttccggca ggctactggg ctccgcccac acacctcccg gcctggttcc taaacgccag       60

ctcggagcaa tccccttggg ctggagccaa atccctgctg tgattttaag gaagaccggc      120

agggtggcaa ccaactatat ctgaggacca gagccatttt ggggcaccag agcttgtgac      180

ctctccatct ccacccagct gggtccaggg gccactctca gcactcacct cagcagctga      240

catcataaag cagacttggg aacctggaag cactctggag aacctttccc tgagacatgg      300

agctttgggg ccgaatgctg tgggccctcc tgtctggccc agggaggagg ggaagtaccc      360

ggggctgggc cttcagctca tggcaacccc aaccacctct ggctgggtta tccagtgcca      420

tagaactggt cagccactgg actggggtct ttgagaagag gggtatccct gaggcccggg      480

aatccagtga gtacatcgtg gctcatgtcc ttggagccaa aacatttcag agcctgaggc      540

cggcactttg gacccagccc ttgacctctc agcaactaca gtgtatccgg gagctgagta      600

gccgtcgatt gcagaggatg ccggtgcagt acatccttgg agagtgggac ttccaggggc      660

tcagcctaag gatggtgccc ccagtgttta ttcctcggcc agaaacagag gaactggttg      720

agtgggtgct ggaagaggtg gcccagaggt cccatgctgt gggatcccca ggcagccccc      780

tcattctgga ggtgggctgc ggatcaggag ccatctccct cagcctgctg agccagctcc      840

cccagagccg agtcattgct gtggataagc gggaagctgc tatctctctg acccatgaga      900

atgctcagag gcttcggttg caggacagga tttggatcat ccacctcgac atgacctcag      960

aaaggagctg gacacacctg ccctggggcc ccatggacct gattgtcagc aaccctccct     1020

acgtcttcca ccaggacatg gagcagctgg cccctgagat ccgcagctat gaagaccccg     1080

cggccctgga tggtggggag gagggcatgg acatcattac ccacattctg gccttggcac     1140

cccggctcct gaaagactct ggtagtatct tcttagaagt ggacccaagg cacccggagc     1200

ttgtcagcag ctggcttcag agccggcctg acctgtacct taatcttgtg gctgtgcgca     1260

gggacttctg tgggaggccc cggttcctgc atatccggag gtctgggcca tagcatggct     1320

gccctgtgga tgccttgtca gtgccgccag cctgaccaga ggggaggtgg atggcacttt     1380

ccagagccca ggttcttatg gcatttccca gggttctgtg atttccccat gctctgcatt     1440

tctaggatat ttctaggaca cctggattgg ctccatcaca tcagagtggc tgagggcagt     1500

tgctctgtgt tggtgaaatt gctgtggggg tatcggggga tatggccagt aaagtattga     1560

gagactaaca aa                                                         1572


<210> 3176
<211> 3307
<212> DNA
<213> Homo sapiens

<400> 3176
aataaatttc tctgtgattg gttggtgaag gttttcaaac cggagctgtg ggcgcggcgc       60

tgctctgccg ttgggtgagg cgcggagcga agtgaagggt ggcccaggtg gggccaggct      120

gactgaatgt atctcctagc tatggactaa ataatacatg gggggaaata aacaagtatt      180

catgagggtg aaaatgtgac ccagcaggaa aattacaact attttcaatt gacgttgaat      240

agggtgagta aattttagct ttttgagtta caatttggct gagatatcag agttacagaa      300

agatggatac tatgatgctg aatgtgcgga atctgtttga gcagcttgtg cgccgggtgg      360

agattctcag tgaaggaaat gaagtccaat ttatccagtt ggcgaaggac tttgaggatt      420

tccgtaaaaa gtggcagagg actgaccatg agctggggaa atacaaggat cttttgatga      480

aagcagagac tgagcgaagt gctctggatg ttaagctgaa gcatgcacgt aatcaggtgg      540

atgtagagat caaacggaga cagagagctg aggctgactg cgaaaagctg gaacgacaga      600

ttcagctgat tcgagagatg ctcatgtgtg acacatctgg cagcattcaa ctaagcgagg      660

agcaaaaatc agctctggct tttctcaaca gaggccaacc atccagcagc aatgctggga      720

acaaaagact atcaaccatt gatgaatctg gttccatttt atcagatatc agctttgaca      780

agactgatga atcactggat tgggactctt ctttggtgaa gactttcaaa ctgaagaaga      840

gagaaaagag gcgctctact agccgacagt ttgttgatgg tccccctgga cctgtaaaga      900

aaactcgttc cattggctct gcagtagacc aggggaatga atccatagtt gcaaaaacta      960

cagtgactgt tcccaatgat ggcgggccca tcgaagctgt gtccactatt gagactgtgc     1020

catattggac caggagccga aggaaaacag gtactttaca accttggaac agtgactcca     1080

ccctgaacag caggcagctg gagccaagaa ctgagacaga cagtgtgggc acgccacaga     1140

gtaatggagg gatgcgcctg catgactttg tttctaagac ggttattaaa cctgaatcct     1200

gtgttccatg tggaaagcgg ataaaatttg gcaaattatc tctgaagtgt cgagactgtc     1260

gtgtggtctc tcatccagaa tgtcgggacc gctgtcccct tccctgcatt cctaccctga     1320

taggaacacc tgtcaagatt ggagagggaa tgctggcaga ctttgtgtcc cagacttctc     1380

caatgatccc ctccattgtt gtgcattgtg taaatgagat tgagcaaaga ggtctgactg     1440

agacaggcct gtataggatc tctggctgtg accgcacagt aaaagagctg aaagagaaat     1500

tcctcagagt gaaaactgta cccctcctca gcaaagtgga tgatatccat gctatctgta     1560

gccttctaaa agactttctt cgaaacctca aagaacctct tctgaccttt cgccttaaca     1620

gagcctttat ggaagcagca gaaatcacag atgaagacaa cagcatagct gccatgtacc     1680

aagctgttgg tgaactgccc caggccaaca gggacacatt agctttcctc atgattcact     1740

tgcagagagt ggctcagagt ccacatacta aaatggatgt tgccaatctg gctaaagtct     1800

ttggccctac aatagtggcc catgctgtgc ccaatccaga cccagtgaca atgttacagg     1860

acatcaagcg tcaacccaag gtggttgagc gcctgctttc cttgcctctg gagtattgga     1920

gtcagttcat gatggtggag caagagaaca ttgaccccct acatgtcatt gaaaactcaa     1980

atgccttttc aacaccacag acaccagata ttaaagtgag tttactggga cctgtgacca     2040

ctcctgaaca tcagcttctc aagactcctt catctagttc cctgtcacag agagtccgtt     2100

ccaccctcac caagaacact cctagatttg ggagcaaaag caagtctgcc actaacctag     2160

gacgacaagg caactttttt gcttctccaa tgctcaagtg aagtcacatc tgcctgttac     2220

ttcccagcat tgactgacta taagaaagga cacatctgta ctctgctctg cagcctcctg     2280

tactcattac tacttttagc attctccagg cttttactca agtttaattg tgcatgaggg     2340

ttttattaaa actatatata tctccccttc cttctcctca agtcacataa tatcagcact     2400

ttgtgctggt cattgttggg agcttttaga tgagacatct ttccaggggt agaagggtta     2460

gtatggaatt ggttgtgatt ctttttgggg aagggggtta ttgttccttt ggcttaaagc     2520

caaatgctgc tcatagaatg atctttctct agtttcattt agaactgatt tccgtgagac     2580

aatgacagaa accctaccta tctgataaga ttagcttgtc tcagggtggg aagtgggagg     2640

gcagggcaaa gaaaggatta gaccagagga tttaggatgc ctccttctaa gaaccagaag     2700

ttctcattcc ccattatgaa ctgagctata atatggagct ttcataaaaa tgggatgcat     2760

tgaggacaga actagtgatg ggagtatgcg tagctttgat ttggatgatt aggtctttaa     2820

tagtgttgag tggcacaacc ttgtaaatgt gaaagtacaa ctcgtattta tctctgatgt     2880

gctgctggct gaactttggg ttcatttggg gtcaaagcca gtttttcttt taaaattgaa     2940

ttcattctga tgcttggccc ccataccccc aaccttgtcc agtggagccc aacttctaaa     3000

ggtcaatata tcatcctttg gcatcccaac taacaataaa gagtaggcta taagggaaga     3060

ttgtcaatat tttgtggtaa gaaaagctac agtcattttt tctttgcact ttggatgctg     3120

aaatttttcc catggaacat agccacatct agatagatgt gagctttttc ttctgttaaa     3180

attattctta atgtctgtaa aaacgatttt cttctgtaga atgtttgact tcgtattgac     3240

ccttatctgt aaaacaccta tttgggataa tatttggaaa aaaagtaaat agctttttca     3300

aaatgaa                                                               3307


<210> 3177
<211> 1968
<212> DNA
<213> Homo sapiens

<400> 3177
ccacccgcct ctggctcctc tccttcccac ccctgccgtg ctccggcagg aagaggtggt       60

gccagggccg ttgctaggat acgaccaaca gctgagaacg cggcgagtat ggaagctgcg      120

tcttaggagc ctgggaaagc acttcgacga gaatagtttg gtttcgtaca caggaaaatg      180

tctaatcaac aggagaagta tgaagctcag aatatagtca attcaacaga agagagtgat      240

gatgcttttg atactgtcac tattccagtt ccctcagaag agcctcaaga gtcagatcaa      300

actgaagagc atgaatctgg aatagaacaa ttcagtgaga gccatgcaat acatgttgag      360

gagcagagtg accaaagctt ttcaagcctg gaaccagaca atgaacaact catggaagag      420

gttatatcac caagacaagt ttcatatact ccgcaacatc atgaaaagca atatgcaatg      480

cagaggccaa atgatgatag tttggcattt ctggataaaa taaagtctgt aaaggaatct      540

ttgcaagaat cagtggaaga ttctctagca acagtaaaag ttgtacttat tccagtgggc      600

caggaaattg taataccttt taaggttgat accattctta aatatcttaa ggaccatttt      660

tcacacttat taggtatccc acattctgta ctgcagataa gatactcagg aaaaattctt      720

aaaaataatg agactctagt acaacatgga gttaagccac aggaaattgt acaagtggaa      780

atcttttcta caaatccaga tctgtatcca gtcagaagaa tagatggatt aactgatgtc      840

tctcaaatca taactgtcac tgtccaaact ggacttgatc aataccagca ggtacctgtt      900

gagattgtca aatctgactt tcacaaacca tttcttggtg gattcagaca taaagtaaca      960

ggagtagagt atcacaatgc tggaacacaa actgtaccta aaaggattcc cgaaagactc     1020

agtatatttt gtagggatac gcagacagtt tttcagaaaa aaaatctcca acaaactaca     1080

aatacaacat ccacacagat gactaacatt ggtgtatatg tatcaaatat gactgataaa     1140

ctggtaacac caggaaagta tttttcagca gcagaatacc atgctcaaag actaaaggcg     1200

gtgatagtga tacagactta ctacaggcaa tggcatgcta aaatcttcgt agagaattta     1260

agaagacaga aaagcttaag actggaatgg gaaacacagc aagaactaag gaagataaga     1320

gaaaaagaag aatggataaa attggactat caccggaggc ataatcctaa aacaaatgaa     1380

gattttgaat ttctttataa tgcattagaa ttctggcggc aagaagaact tacacgtatt     1440

aaccaatctt ttactggagc tgaaaggaaa gctgctctgt gtgaacttct ggaaaaagag     1500

actcagataa ttgcttccat tgggagacat agatacattg cttatatggc aaatcaggaa     1560

gcagcaatac aagctttttt ggataagtgt tcagctccaa aaatatggag aacccctaat     1620

ggcaaaacaa ttgagatgga tacgcagttc accatcagag ccagagagct gcaaaatatc     1680

tataagtgca ttatgctgaa aaatatctcc caagatgaga ggctggatgt gctgttaact     1740

cttaaacaca ctgtaaagga acatgaatgt aaactaactc aggaaattct agaattgatt     1800

gacagagagg ttgaccttat gatgagagga gtcaaacatc ataaccttga aggactcaga     1860

aaaagaattg cgacactctt ttttcattat atcaaaacac ctctgtttaa tcctgaagtt     1920

gcaaaatacc ttaagatggg tggagaatat ctttccatgg cattatag                  1968


<210> 3178
<211> 1399
<212> DNA
<213> Homo sapiens

<400> 3178
ctctaggcca caatgtccaa gtacctggga cagggtctgg cttaccaaca tggtacagga       60

cggcactttt aaaaccaggg actcgacttg gacgtgcgag tcaacaagga tggctgcagc      120

tcctccaagt tactgttttg ttgccttccc tccacgtgct aaggatggtc tggtggtatt      180

tgggaaaaat tcagcccggc ccagagatga agtgcaagag gttgtgtatt tctcggctgc      240

tgatcacgaa ccggagagca aggttgagtg cacttacatt tcaatcgacc aagttccaag      300

gacctatgcc ataatgataa gcagacccgc ctggctctgg ggagcagaaa tgggagccaa      360

tgaacatgga gtgtgcatag ccaatgaagc catcaacacc agagagccag ctgccgagat      420

agaagccttg ctggggatgg atctggtcag gcttggttta gaaagagggg aaacagctaa      480

agaagcctta gatgtcattg tctccttgtt ggaagaacat ggacaaggtg ggaattactt      540

tgaagatgca aactcctgcc acagcttcca aagtgcatat ctgattgtgg atcgtgatga      600

agcctgggtg ctcgagacca tagggaagta ctgggctgcc gagaaagtca cagagggagt      660

gaggtgcatt tgcagtcagc tttcgctcac cactaagatg gatgcagagc atccggaact      720

caggagttac gctcagagcc aaggttggtg gacgggagag ggcgagttca atttttccga      780

agtcttttct ccagttgagg atcatctaga ctgcggtgct ggcaaagaca gcttagaaaa      840

acaagaagaa agcatcacag tgcagactat gatgaacacc ttacgggaca aagccagcgg      900

agtgtgcata gactctgagt ttttcctcac cacagccagt ggagtgtctg tcctgccgca      960

gaatagaagc tctccgtgca ttcactactt cactggaacc cctgatcctt ccaggtccat     1020

attcaagcct ttcatctttg ttgatgacgt aaaacttgtc cccaaaacac agtctccctg     1080

ttttggggat gacgaccctg ccaaaaagga gcctcggttc caggagaaac cagaccgccg     1140

gcatgagctg tacaaagccc acgagtgggc acgtgccatc atcgaaagtg accaggagca     1200

aggtcgcaag ctgaggagca ccatgctgga gctggagaag caaggcctgg aagccatgga     1260

agaaatcctg accagctccg agccactgga ccctgcggaa gtgggggacc ttttctatga     1320

ctgtgttgac acggagatta agttctttaa gtgaagtaag cgttcccttt ccccttctta     1380

tttaagactt cccacctta                                                  1399


<210> 3179
<211> 4329
<212> DNA
<213> Homo sapiens

<400> 3179
aagattatag agacttgctt tagaaccaca agaagaaaga ggaggccggc ttttcagcta       60

gcatcatggc gtggccgtgc atcacgaggg cctgctgcat cgcccgcttc tggaaccagt      120

tggacaaagc ggacatcgct gtgccgctgg ttttcaccaa gtactcggag gccaccgagc      180

acccgggcgc cccgccgcag ccaccgccgc cgcagcagca ggcgcagccg gcgctcgcgc      240

ccccctcggc gcgcgcggtt gccatagaga cgcagccagc ccagggcgag ttggatgcag      300

ttgcccgggc aacggggcca gcgcctgggc ctaccggcga gcgcgagccg gcggcgggcc      360

ccggccggag cgggccgggc ccgggcctgg gctccggctc cacctccggc cccgcggact      420

cggtgatgcg gcaggattac cgagcctgga aggtgcagcg gcccgagccc agctgccggc      480

cgcgcagcga ataccagccc tccgacgctc ccttcgagcg cgagacccag taccagaagg      540

acttccgcgc ctggccgctg ccgcgccgcg gggaccaccc gtggatcccc aagcccgtgc      600

agatctctgc ggcctcccag gcgtcggcgc ccattctcgg ggcgcccaag cgccggccgc      660

agagccagga gcgctggcca gtgcaggccg ccgctgaggc ccgggagcag gaggcggccc      720

ccggcggagc gggtggcctg gcggccggaa aggcgtccgg ggcggacgag cgcgacacgc      780

gcaggaaggc cgggcctgcc tggattgtgc gccgcgccga gggcctgggg cacgagcaga      840

cgccgctgcc cgcggcccag gcccaggtcc aggccaccgg ccccgaggct ggcagggggc      900

gcgccgcggc ggacgccctc aaccggcaaa tccgcgagga ggtggcgagt gcagtgagca      960

gctcctacag gaatgaattc agggcatgga cggacatcaa gcctgtgaaa ccaataaagg     1020

ccaagcccca gtacaagccc ccagatgata agatggttca tgagaccagc tacagtgctc     1080

agttcaaagg agaggccagc aagccaacaa cagctgacaa taaggtcatt gatcgcagaa     1140

gaatacgcag cctctacagc gaacccttca aggaaccccc aaaggtggaa aaacctagtg     1200

ttcagagttc caaaccaaaa aagacctcag cgagccataa gcccacgagg aaggccaaag     1260

acaagcaggc ggtgtcaggc caggctgcca agaaaaagag cgcggagggc ccgagtacca     1320

ccaagccaga cgacaaggag caaagcaaag agatgaacaa taaactggct gaggcgaaag     1380

agtaaatttc cctgcacttt ccttttactc ttctctctct ctccctcccc ccaacttttt     1440

ttttttaaac caacaaacca aaaaaggcca caaaattaat tagaggcttc tcatctgcct     1500

tggtcctgag tgttccagga gctctttggt ttggcttctt ttgatggaag aatcctgctt     1560

cacagactga gtggcaggcc tcctcctgag ggcagcccct ggagcaccag gaagcgttgc     1620

cgctggctgt gccctcccct ggcactctga ctgcatgctg atgagcaagg caggcaggtc     1680

tgagaggcga aacgaatctc ccggcagtgc ttggaagtgt ctgtggggtc tcctcctccc     1740

agatccccaa gatctgtgtc actggtcgat tttgaacttt aggtacatgt gttcttttca     1800

aaaattcaga gaatcgtcat gtgccacaga agctcagcct gggcttcagc aattgacaaa     1860

atttgaagaa atattaaaca aaaataacaa aaaaagaaac aaccttggcc ttaatgtcaa     1920

taaaagggag ttgtgtctgt taagtggtct tttcatagaa tcgtccatta gaaatgtgtg     1980

cctgtgttta gcttcctatc agtgggcttt aaattgtata ccgagtcata gatacgccac     2040

tgataactaa aactagatca gggctggtga agaaggttag gtgttttagg tacattccag     2100

ctgtcatagg aagatcacag aaatgaggag gctgttttcc tctgattctc ctcggccgac     2160

cacctgtcca atgctgctgg tttcgcagag cgaccggttg gagatgtctg aggaagaaag     2220

ttcaaggtgt agggatagtg tgtttggaat ttgactttcc atttctgaga cccaaggggg     2280

cgtagatgta gtggcaagtg tggcgatgtt tactctccct tcctgaaccg ctctggtctg     2340

ctcctcagag agggcagcgg tgccaggcct caggtcaggg agaatgtctg tgacttagct     2400

gcagactagg agactgccct gctaactaat tagcaagcag ctttgacctc attaatatat     2460

aaaagcagct ctcagtatat tccgtgtcgt gtgtgtgtgt ggccaaagcc cccaagggtg     2520

gcaagtgcca ccttcgctgt gctagagttg tgttgtagga attagtcagg gagttgttgt     2580

gaaaaaaaaa accccagtgc ttgtgaggga actcaaaata gttaccagaa aaataatatt     2640

tgccaatatg acgtgtatat tgctcagcac actctgtatc tcctgtcctt aaaatcctct     2700

tgtccccggc attctgacac actgggctgc cgtccggtgt caagccccgg cgcaggcttg     2760

ctcttctttt acaatgaaag gggtgaagag tgagggtctc acagttcctt acctcaaagt     2820

ccctttaggt ccttctggtt tggaggaagt ggagcctcca cgaactctct cttactccga     2880

ccattcaggc agcaaagtct ctgcttacat cattttggtt gtcaccttgg ggctgagtga     2940

gaagtctttt gtaaattaat tcggcgtgtg ctacatgagc cataattatt aacagaacag     3000

gaatatcaga aacgaagttg ttgatcaggc ccactgcgac cttcctttct atctcagggt     3060

ttaaaactgt gaggaaggag aagtatgaag gaaggtagaa aatgctggtg ggtctccgtg     3120

tttatgagtc acagattttg aaagctatca ggaaatgact agagtggatc ctggcactga     3180

ttccaactct ttgccagcta atcttaacat ttagcagaaa gctctagcaa catgatctta     3240

attgtatcca gaggatttgc caatgtatgt tcagtctctc aagatttggc attagtcaga     3300

catgttgatg ctagccacaa tttggatttc tccatagaat aatcatttat ttttgcagat     3360

caaataaatc agagtttaca atgcacaggg gatcatttat ttagcattcc cttgctagaa     3420

gcccgtgtgc caggcactgt gctaggcgtg gtgggcagta taaagaaatc tgtctccaca     3480

gccacacaac cagagggtgc acatgacttg atccctatga ccaagtcaag ttggtgttgc     3540

ccaaatcgca gtttgacata agggtcccac aggcttcccc accccccgcc cccactcact     3600

gccccaggga ccaacttcct accctcaccc aaggctttag aggacctgta gcatgtcttt     3660

ttcaacctgt cagtatcccc ttctgcttaa cacacccact gagaaaaccc tgtttgtagt     3720

tcactttgac tcttgaatgt gtcactttac tggcaagaga cttcctttga tttctactgt     3780

ttacaaataa aactcagcca gtctcattct atatcccaaa cgtactgaat gaaactgatt     3840

ttggttccac aagcagtgtt tgggtgttgc cttcctgaag gtgaccaagc ttccaaagct     3900

cgtcccactg gcctctgtac atttccctgt ggttctccgt ccttccctgg cgagggagct     3960

gggactgaag ctttcccgct gtttccctgc ctgcaaaagc agccccaaga gctgcgcatt     4020

ggcttccctc agcaatctgt cctgtctgtg ctcccattcg gtccacatag ctttctttgc     4080

ctctctgagg cagacaggaa gtgtctaatt acgattttgt ggcctgggtt ttgttgcata     4140

ccacagattg tctatgtaac atgtagcgca cacctctctt ggtgctattt cattcctgct     4200

gtaagagaat gacaaaaata ttcatgtata gccaattgat tgtgacgtgc ttgtggtctg     4260

tgcttgctca gaaaaacaaa caaacaaaca gtttttccaa ttataaataa atgctaaaga     4320

cgaacacca                                                             4329


<210> 3180
<211> 1094
<212> DNA
<213> Homo sapiens

<400> 3180
ctcctggcca cagcttgagc tgggaggagg gtggaggctg ggccgcctcc tggacccctg       60

ccctccctgc ccggccttcc aaggcccggc agcctcagtc cactgctggg cctggaacac      120

ggagcagtgg ctgccctgcg aggaggtcct agagcagctc cagcaggatg gcggctccag      180

cgtctctaag gcctgcaggg ggtccagccc catggggggc gccctaggcc tccgacagct      240

ccccatctgt gctcctgcct gccggccatc ctcaggccac tcgccatggg cggctgcttc      300

tccaaaccca aaccagtgga gctcaagatc gaggtggtgc tgcctgagaa ggagcgaggc      360

aaggaggagc tgtcggccag tgggaagggc agcccccggg cctaccaggg caatggcacg      420

gcccgccact tccacacgga ggagcgcctg tccacccctc acccctaccc cagccctcag      480

gattgcgtgg aggctgctgt ctgccacgtc aaggacctcg agaatggcca gatgcgggaa      540

gtggagctgg gctgggggaa ggtgttgctg gtgaaggaca atggggagtt ccacgccctg      600

ggccataagt gtccgcacta cggcgcaccc ctggtgaaag gcgttctgtc ccgtggtcgg      660

gtgcgctgcc cctggcacgg cgcctgcttc aacatcagca ctggggacct ggaggacttc      720

cctggcctgg acagtctaca caagttccag gtgaagattg agaaggagaa ggtgtacgtc      780

cgggccagca agcaggccct acagctgcag cgaaggacca aggtgatggc caagtgtatc      840

tctccaagtg ctgggtacag cagtagcacc aatgtgctca ttgtgggtgc aggtgcagct      900

ggcctggtgt gtgcagagac actgcggcag gagggcttct ccgaccggat cgtcctgtgc      960

acgctagacc ggcaccttcc ctacgaccgt cccaagctca gcaagtccct ggacacacag     1020

cctgagcagc tggccctgag gcccaaggag tttttccgag cctatggcat cgaggtgctc     1080

accgaggctc aggt                                                       1094


<210> 3181
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3181
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cgaagtcctc      180

accagtgaac ggagacctct ctgaactaag gataccatgg ccacgtcagc cccactacgg      240

agcctggaag aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc      300

attgactgtg gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg      360

agccgccccg tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg      420

tggcaactgg ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag      480

ccgggagagg tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag      540

ctgcactact actgtgagga cgacgggaag ctgctgtgcg tg                         582


<210> 3182
<211> 2367
<212> DNA
<213> Homo sapiens

<400> 3182
acccttcgta gtccgatttg agcactaaag gttgctgact gtgtagtggg caaaggatca       60

agtgatgccg tttcgcctga cacgttcaca gctactccag cctgcaggag ggaccttccc      120

acccccaaga cctttgtact tcgttctgta ctgaagaaac cctctgttaa gatgtgtcta      180

gagagcttac aggaacactg taacaacctc tatgatgatg atgggactca tccgagctta      240

atctcaaatc tcccaaactg ttgcaaagag aaagaagcag aagatgaaga aaattttgaa      300

gcacctgcct ttctaaatat gaggaagagg aagagagtta cttttggaga ggacttaagc      360

ccggaagtgt ttgatgaatc tttgccagca aatactccat tgcgtaaagg aggaacacct      420

gtttgtaaaa aagacttcag tggtctcagt tccctgctgc ttgagcagtc acctgttcct      480

gagccattac ctcaaccaga ttttgatgac aagggggaga atcttgaaaa catagaacca      540

cttcaagtat catttgccgt tctcagttct cctaataaat catcaatctc tgagaccctt      600

tcaggcactg atacctttag ttcttcaaat aaccatgaga aaatatcctc tcctaaagtt      660

ggtagaataa caaggacttc taacagaaga aatcaattgg tcagtgttgt agaagagagt      720

gtttgcaact tattgaatac agaagttcag ccttgtaaag aaaagaaaat taataggagg      780

aagtctcaag aaacaaagtg tacaaagaga gcacttccta agaagagtca ggttttaaaa      840

agttgcagaa agaagaaagg aaagggaaag aaaagtgttc agaaatcttt atatggggaa      900

agagacattg cttctaagaa gcccctcctc agtcctattc ccgagctgcc tgaagtccct      960

gagatgacac cttccattcc gagcatccga agactgggtt caggttattt cagttcaaat     1020

ggcaaactgg aagaagtgaa gactcctaaa aatccagtga aaagaaagga tcttttgcgt     1080

catgacccag atttgcatat gcatcaaggc tatgataaat atgatgtctc tgaattctgc     1140

tcttatataa aaagttcctc atcgcttggc aatgctactt ctgatgaaga tccaaataca     1200

aatataatga acattaatga aaataaaaat attccaaaag caaaaaataa gtcagaaagt     1260

gaaaatgaac caaaagctgg aactgacagt cctgtttctt gtgcttctgt aactgaagaa     1320

cgtgtggcat cagatagtcc caaacctgct ctgaccctgc agcagggtca agaattttct     1380

gctggtggtc aaaatgcaga aaacctttgt cagttcttta aaatttcacc agatttaaac     1440

ataaagtgtg aaagaaagga tgacttctta ggagctgcag aaggaaaact gcaatgcaat     1500

cgtttaatgc ctaattcaca aaaagactgt cattgtttag gagatgtctt aattgaaaat     1560

acgaaagaat ctaaaagcca gagtgaggat ttgggaagaa aacccatgga aagtagcagt     1620

gttgtgagtt gcagagacag gaaagataga agacgttcca tgtgttattc tgatggtcga     1680

agtttacatt tggaaaaaaa tggaaatcac acaccatcct ccagtgtggg cagctctgta     1740

gaaattagtt tagaaaattc tgaactgttt aaagatttgt ctgatgccat tgagcaaacc     1800

tttcagagga gaaatagtga aaccaaagtg cgacgtagca cgaggctaca gaaggattta     1860

gaaaacgaag gtcttgtatg gatttcactt ccacttcctt ccacttccca aaaagccaaa     1920

agaagaacaa tatgtacatt tgacagcagt ggatttgaaa gtatgtctcc cataaaagaa     1980

actgtgtcct ccagacaaaa accgcagatg gcacctcccg tctcagatcc agaaaacagc     2040

cagggccctg ctgctggttc ttccgatgaa cctggtaaga ggaggaagag cttttgtata     2100

tctacacttg caaatactaa agccacttcc cagttcaaag gctaccggag aagatcctct     2160

cttaatggga agggagagag ctctctgact gccttggaaa ggattgaaca taatggagaa     2220

agaaagcagt aattgacatt tcctgcagag tctgtggcaa gagggaaagt aaccatctat     2280

gctgaaatga tctgtctagt tcccattctc tgttcaacct cagtgtttca aaagttccta     2340

ataaataaac tcatttgagt tgaacct                                         2367


<210> 3183
<211> 3652
<212> DNA
<213> Homo sapiens

<400> 3183
gtgcgcctgc gcgttggcgg cggctgtggc ggggcccggc ggggagctcc ctcgcctggc       60

tctcggcggc ctgatggagt aagaggggtt ggctgtgaat ctgtgacgtt gagtgcttca      120

gatctggtca ctatggtacg agaacgaaaa tgcatattat gccacatcgt gtacagctca      180

aaaaaggaga tggacgaaca catgcggagc atgttgcatc acagggaact tgagaacctc      240

aagggcaggt ttggcataga aatggtaccc cttgttcaaa atgaacaaga agccttagat      300

ttggatgggg aacctgatct gtccagtcta gaaggattcc agtgggaagg tgtttccatt      360

tcctcgtccc ctggcttggc aagaaagcga agcctttctg agagcagcgt gatcatggac      420

agagctcctt ctgtgtatag cttcttcagt gaggaaggta caggcaaaga aaatgagccc      480

cagcagatgg tttcacctag taactcattg agggctggac agagccagaa agcaaccatg      540

cacctcaaac aagaagtgac acctcgggct gcctccctcc gaacaggtga aagggctgaa      600

aatgttgcta cccaaaggcg acatagtgca caattatcct ctgaccatat aatacctttg      660

atgcatttgg caaaagactt gaacagccag gagaggtcta taccaccgtc agagaatcag      720

aattcccagg agagtaatgg agagggaaac tgtctgtcat caagcgcatc ctcagccctt      780

gcgatctcca gtttagcgga tgcagccaca gatagtagct gtacctctgg tgctgaacaa      840

aatgatggcc aaagtattag aaagaaacga agagccactg gagatggatc ttctcctgaa      900

ctcccaagtc ttgagagaaa aaataaaaga aggaaaatta aaggaaaaaa agaacgttct      960

caggttgacc agctgctgaa tatttcttta agggaggaag aacttagtaa gtcattgcag     1020

tgcatggata acaatcttct gcaagcccgt gcagcccttc agacagctta tgtggaagtt     1080

cagaggctac ttatgctcaa gcagcagata actatggaga tgagtgcact gaggacccat     1140

agaatacaga ttctacaggg attacaagaa acatatgaac cttctgagca cccagaccag     1200

gttccctgta gcctcacacg agaacgaagg aacagtagat ctcaaacatc cattgatgcc     1260

gcactgctgc ccactccctt tttcccactt tttctggagc ctccatcttc ccatgtgtct     1320

ccatcaccca ccggagcctc tcttcaaata accacgtctc ctactttcca aacccatggc     1380

agtgtccctg ctccagactc atcagttcag attaaacaag agcccatgtc tcctgaacaa     1440

gatgagaatg tgaatgctgt gccaccaagc tctgcctgca atgtgtccaa ggaattactg     1500

gaagctaata gagagatcag tgacagttgt ccagtttatc cagtcatcac tgctagattg     1560

tccttaccag agtcaacaga aagtttccat gagcctagcc aagaactgaa gttttctgtg     1620

gagcaaagaa ataccagaaa cagagaaaac tctccctctt cccaatcagc tggtctttct     1680

agcataaata aagaagggga agagccaacc aaaggcaata gtgggtctga agcctgtacc     1740

agttcttttc taagattgtc ttttgcttca gaaacccctt tggagaagga accccactct     1800

ccagctgacc agcctgaaca acaggcagaa tccactttga catcagctga gactagggga     1860

agcaagaaaa agaagaaact ccggaagaag aaaagtctac gggctgccca tgttcctgag     1920

aatagtgaca ctgaacagga tgttttgact gttaaacctg taaggaaagt aaaagctgga     1980

aagttaatta aaggggggaa agtaacaacc tccacttggg aagacagcag gactggtcgg     2040

gagcaggaga gtgtcagaga tgagccagat agtgactcgt ctctggaagt cctagaaatt     2100

cctaatcctc agttagaagt agtagccatt gattcttcag aatcaggaga agagaaacca     2160

gacagcccat ctaaaaagga tatttggaac tctacagagc aaaacccact agaaacgtct     2220

cgttctgggt gtgatgaagt tagctctacc agtgaaattg gcactcgcta taaagatggc     2280

atccctgtaa gtgtggcaga aactcagact gtgatctcct ccataaaagg atcaaagaat     2340

tcttcagaaa tatcttcaga gccaggagat gatgatgaac ccacagaagg aagctttgag     2400

ggacaccaag ctgccgtaaa tgcaattcag atatttggga acttgctata tacctgttca     2460

gcagataaaa ctgttcgggt ttataatctg gtgagtcgga aatgtattgg tgtctttgag     2520

ggtcatacct ccaaagttaa ctgcctcctg gttactcaga cctccgggaa gaatgctgcc     2580

ctttacaccg ggtccagtga ccataccatc cgctgctata atgttaagag ccgagagtgt     2640

gtggagcagt tacagctgga agaccgggtc ctctgcctcc acagtagatg gcgaatcctc     2700

tatgcgggac tggcaaatgg cactgtggtc accttcaaca taaagaacaa caaacgactt     2760

gagatctttg aatgccatgg ccctcgggca gtcagctgtc ttgctacagc tcaggaaggt     2820

gcccgaaaac tgctggtcgt ggggtcttat gactgcacaa ttagtgtacg cgatgcccgg     2880

aatggactgc tcctcagaac tctggagggc catagcaaaa ccattctttg catgaaggtg     2940

gtgaatgatc tcgtgttcag tggctccagt gatcagtcag tccatgctca caacattcac     3000

actggtgagc tcgtgcggat ctataaaggt cacaatcatg cagtgactgt ggtgaatatc     3060

ctaggaaaag tgatggtgac tgcttgcctg gataaatttg ttcgtgtcta tgaattacag     3120

tctcatgatc gattacaagt ttatggagga cacaaagaca tgattatgtg tatgaccatc     3180

cataaaagca tgatttacac tggctgttat gatggcagta ttcaggccgt gaggcttaat     3240

ctgatgcaga attaccgctg ttggtggcat ggttgctctc tgatatttgg cgttgtagat     3300

catttaaaac aacacttgct gaccgaccac actaatccca acttccagac tctgaaatgt     3360

cgctggaaga actgcgatgc ttttttcact gctaggaaag gatccaaaca ggatgctgca     3420

ggacatattg aacgacatgc tgaagatgac agcaaaattg attcatgaag ttttttgcct     3480

cccacgttgg gaagtcatta gttgaactat tttcacattg gccccccaca caggccactc     3540

tcttcccttt cttggtgaag taaggaagga gaaagtggtt actagccagg cataccccta     3600

gcataagtct gggcagctct atgggatgat aaattacact tttaagttct tg             3652


<210> 3184
<211> 567
<212> DNA
<213> Homo sapiens

<400> 3184
tggttggttt tgttttgttt tgtttttgag gacccaaagc atcagaattg tacaaactat       60

tctctttcct attgcatttt cccttgagaa catgaactga caaggaacaa gcatcttcag      120

ataataagaa acagatacct aatgaagctt ctgctagaag tgaaagagac acatcagacc      180

tagagcaaaa ctggtcattg caagatcatt atagaatgta ttcacccata atataccaag      240

ccctctgtga gcacgtgcag actcagatgt cactgatgaa tgacttgact tcaaagaaca      300

tccctaatgg aattcctgct gtaccatgcc atgctccctc tcattctgaa tctcaggcaa      360

ctcctcattc tagttatggc ttatgtacct ccaccccagt ctggtcactt cagcggccac      420

cctgccctcc aaaggttcat tctgaagttc aaactgatgg caacagtcag tttgcatcac      480

aaggtaaaac agtttctgca acctgtactg atgttctacg gaattcattt aataccagtc      540

ctggagttcc atgtagcctg cccaaaa                                          567


<210> 3185
<211> 439
<212> DNA
<213> Homo sapiens

<400> 3185
ctgcgaagag agcagaaggg gtgctgctgt aggaaatcaa tggctcggaa gaccacactg       60

aggaaggtgt gagttgatac tggaagatct ccaggtttga ggcatcttca gaggtatatg      120

gtggttttgt gtgtgttgag ggtgtggtag cgcagcagct ccctagggaa ttagaaggtt      180

ttattgaaca tttaccctgt gacaggcact gcaggcattc agcgcgcagt gtcatcttca      240

ttttacaggc atcatggccg ccctcagacc ccttgtgaag cccaagatcg tcaaaaagag      300

aaccaagaag ttcatccggc accagtcaga ccgatatgtc aaaattaagc gtaactggcg      360

gaaacccaga ggcattgaca acagggttcg tagaagattc aagggccaga tcttgatgcc      420

caacattggt tatggaagc                                                   439


<210> 3186
<211> 519
<212> DNA
<213> Homo sapiens

<400> 3186
gtgacctcga ggcagcctca gcacggcact ctcttgggtc ctcttccagg ctcacactgg       60

gcgacagcgg agaggctctt ggacggggca gagctcgcgc cgagacctgc atgtccgcgt      120

cttgtgacgg gtgtgtggga agccgcccgc ctgtgcatct tgcttccggg tattcgctgg      180

ctgatttact ggttttagag atggggatgg gcacccagtg ctggactgaa gaccagagaa      240

ggtggagctc cctgtggcct tggtctcacc tctcttcagt cctcctggct gacaaggagg      300

gtgggccgcc ggcagtggac gaggtgttgg atgaggctgt gcccgagtac cgggcgccgg      360

ggaggaagag cctcttggag atccggcagc tggacccgga cgacaggagc ctggccaagt      420

acaagcgggt gctgctgggg cccctgccac cggccgtgga cccaagcctg cccaatgtgc      480

aggtgaccag gctgacactc ctgtcggaac aggctccgg                             519


<210> 3187
<211> 2148
<212> DNA
<213> Homo sapiens

<400> 3187
ccggaagttg cagcgaggtg gttgcgcctg cgcagtgcat caccgcaggc gggcctcgcg       60

ggtccgggag cgcggcggag acgatgcctg agatcagagt cacgcccttg ggggccggcc      120

aggacgtggg ccgaagctgc atcctggtct ccattgcggg caagaatgtc atgctggact      180

gtggaatgca catgggcttc aatgacgacc gacgcttccc tgacttctcc tacatcaccc      240

agaacggccg cctaacagac ttcctggact gtgtgatcat tagccacttc cacctggacc      300

actgcggggc actcccctac ttcagcgaga tggtgggcta cgacgggccc atctacatga      360

ctcaccccac ccaggccatc tgccccatct tgctggagga ctaccgcaag atcgccgtag      420

acaagaaggg cgaggccaac ttcttcacct cccagatgat caaagactgc atgaagaagg      480

tggtggctgt ccacctccac cagacggtcc aggtagatga tgagctggag atcaaggcct      540

actatgcagg ccacgtgctg ggggcagcca tgttccagat taaagtgggc tcagagtctg      600

tggtctacac gggtgattat aacatgaccc cagaccgaca cttaggagct gcctggattg      660

acaagtgccg ccccaacctg ctcatcacag agtccacgta cgccacgacc atccgtgact      720

ccaagcgctg ccgggagcga gacttcctga agaaagtcca cgagaccgtg gagcgtggtg      780

ggaaggtgct gatacctgtg ttcgcgctgg gccgcgccca ggagctctgc atcctcctgg      840

agaccttctg ggagcgcatg aacctgaagg tgcccatcta cttctccacg gggctgaccg      900

agaaggccaa ccactactac aagctgttca tcccctggac caaccagaag atccgcaaga      960

ctttcgtgca gaggaacatg tttgagttca agcacatcaa ggccttcgac cgggcttttg     1020

ctgacaaccc aggaccgatg gttgtgtttg ccacgccagg aatgctgcac gctgggcagt     1080

ccctgcagat cttccggaaa tgggccggaa acgaaaagaa catggtcatc atgcccggct     1140

actgcgtgca gggcaccgtc ggccacaaga tcctcagcgg gcagcggaag ctcgagatgg     1200

aggggcggca ggtgctggag gtcaagatgc aggtggagta catgtcattc agcgcacacg     1260

cggacgccaa gggcatcatg cagctggtgg gccaggcaga gccggagagc gtgctgctgg     1320

tgcatggcga ggccaagaag atggagttcc tgaagcagaa gatcgagcag gagctccggg     1380

tcaactgcta catgccggcc aatggcgaga cggtgacgct gcccacaagc cccagcatcc     1440

ccgtaggcat ctcgctgggg ctgctgaagc gggagatggc gcaggggctg ctccctgagg     1500

ccaagaagcc tcggctcctg cacggcaccc tgatcatgaa ggacagcaac ttccggctgg     1560

tgtcctcaga gcaagccctc aaagagctgg gtctggctga gcaccagctg cgcttcacct     1620

gccgcgtgca cctgcatgac acacgcaagg agcaggagac ggcattgcgc gtctacagcc     1680

acctcaagag cgtcctgaag gaccactgtg tgcagcacct cccagacggc tctgtgactg     1740

tggagtccgt cctcctccag gccgccgccc cttctgagga cccaggcacc aaggtgctgc     1800

tggtctcctg gacctaccag gacgaggagc tggggagctt cctcacatct ctgctgaaga     1860

agggcctccc ccaggccccc agctgaggcc ggcaactcac ccagccgcca cctctgccct     1920

ctcccagctg gacagaccct gggcctgcac ttcaggactg tgggtgccct gggtgaacag     1980

accctgcagg tcccatccct ggggacagag gccttgtgtc acctgcctgc ccaggcagct     2040

gtttgcagct gaagaaacaa actggtctcc aggctgtctt gcctttattc ctggttaggg     2100

caggtggtcc tagacagcag tttccagtaa aagctgaaca aaagacta                  2148


<210> 3188
<211> 1551
<212> DNA
<213> Homo sapiens

<400> 3188
aacctggccg gcaatcagag aggatggggc cactgctggt cgccctttct ctcagagtaa       60

aagtaattgt ccaggagagt ggtgtttggg tgtggaaggg acgaagtctg gctctgtcgc      120

ccaggctgga gtgcagtggc acgatcttgg cccactgcaa tctccacttc ccaggttcaa      180

gcgattctcc tgcctcagcc tcccgagtag ctgggactac aggctcaggt ggccttcctt      240

cagggagaga ggaaagggca ggagaatcta aagacggacc tggtgcggcg gatcaagatg      300

ctagagtatg cgctgaagca ggaaagggcc aaatatcata aactgaagtt tgggacagac      360

ctgaaccagg gggagaagaa agcagatgtg tcagaacaag tctccaatgg ccccgtggaa      420

tcggtcaccc tggagaacag cccgttggtg tggaaggagg ggcggcagct tctccgacag      480

tacctggaag aggtgggcta cacagacacc atcctcgaca tgcggtccaa gcgcgtccgt      540

tccctgctgg gccgctcgct ggagctcaac ggggcagtgg agccgagtga aggggccccc      600

agggctccac caggccctgc agggctcagt ggtggggagt cgctgctggt gaaacagatc      660

gaggagcaga taaagaggaa cgcggcaggc aaagatggca aagagcgctt gggcggctca      720

gtgctggggc agatcccctt cctgcagaac tgcgaggacg aagacagcga cgaggacgat      780

gagctggaca gcgtgcagca caagaagcag cgtgtgaagc tcccatccaa ggctctggtg      840

cccgaaatgg aagacgagga tgaggaagac gactctgagg atgctatcaa tgagtttgat      900

ttcctgggct caggagagga tggggaaggg gctccagacc ctcggcggtg cactgtggat      960

gggagccccc atgagctggg gccagagctt cacagcccca cagagtggca gggggccctc     1020

agtgtgggga aggcgtcacc tatgccagac tgggttggaa ctgctgggtg actccggccc     1080

tatgcctcga ccctgcagaa agccgtcggg tcaaactcca aggcattctg gctgacctgc     1140

gggatgtgga tgggctgccc ccaaaagtga ctggcccgcc tcctggcaca ccccagcccc     1200

ggccacatga aggttccttt ggcttctcct cagacgtctt catcatggac actatcgggg     1260

gcggggaggt gagcctgggg gacttggcag atctcaccgt caccaacgac aacgacctca     1320

gctgcgatct gtctgacagc aaagatgctt ttaagaagac gtggaacccc aagttcaccc     1380

tgcgctcgca ctacgacggc attcgttccc tggccttcca ccacagccag tcggctctgc     1440

tcaccgcctc cgaggacggc acgctcaagc tctggaacct gcagaaggcg gtcacggcca     1500

agaagaatgc ggcgctagat gtggaaccta tacatgcttt ccgggctcac a              1551


<210> 3189
<211> 1869
<212> DNA
<213> Homo sapiens

<400> 3189
tttccggcgg cgccgggcga gaagcgcgac tggagtctgg ggctgcggct tcccagaggc       60

gcgagtcgct tttccaggag ccgaggccca aacggggccg ggcctgaagg gtcccccgcc      120

agcccgcggc cgcgccatca atcgccgccg cctcgtcccg cttctcggct gaggcgccgc      180

gcggccaggc agcgggtcca ggcctcagcc gcgcgcccag gggcctccgg ggccctcccg      240

ggtcagcatg cccggggtga aactgaccac ccaggcctac tgcaagatgg tgctgcacgg      300

cgccaagtac ccgcactgcg ccgtcaacgg gctcctggtg gccgagaagc agaagccgcg      360

taaggagcac ctccccctgg gcggccccgg cgcccaccac accctcttcg tggactgcat      420

ccccctcttc cacggcaccc tggccctcgc ccccatgctg gaggtggctc tcaccctgat      480

tgattcatgg tgcaaagatc atagctacgt gattgctggt tattatcaag ctaatgagcg      540

agtaaaggat gccagtccaa accaggttgc agagaaggtg gcctccagaa tcgccgaggg      600

cttcagcgac actgcgctca tcatgtgact actgtgaaga ctggccagag gcacagagga      660

tctcagcctc gctcctggac agccggtcct acgagacgct cgtggatttc gataaccacc      720

tggatgacat tcggaatgac tggacaaacc cagagatcaa taaagctgtc ctacacttgt      780

gctaggcagg caccgctgtg actgggctcc gggcctttcc actacgttga agaagaaaac      840

ctatttttaa atgtaaataa aatatcttgt agcctgtgtg gaaagctgac cgttttaaga      900

agtggcatgt gccttgaaag ggggcagaat gttcagtcgg tcgtgttttt aacacagagt      960

ctctagaaga ggtgcagaca tcccgtctga ctgtccctgt ggactctctc agttgtatgt     1020

tgctataatc ctccaaatca aagctctttc tgcttgtgca agattgttcc tattaaacag     1080

ttttaactaa ccttttataa tctggagaga atacttttta aggcttttga actatctttt     1140

tttaaaaaaa aaaaaaaaag cccacatctt atactccaat gagtgtgttt gtgagttttt     1200

atcctgtttg aattttgatg tcgtccaggc gtcctgggat cagggtagac acgtggagtg     1260

ctggtgctga gctgtttgag aagctctgtg tgggtgtttc tgtggtcagg taggctgggc     1320

tgtgaacagc actgctccac atggtgtcgg ctcacagagc caccgcaact ctgcccagcg     1380

ggagtgacac cactgatgcc acagaagcct ttatcgttag gggcaaaagc agacatctct     1440

ggtagcagga gctcagtgtg gtgctcttca gccacgcaga aagctcacgt gcctgcaggg     1500

ccaggaaagg gaaatgatcg tttcttttgt attaggaaaa acaagactta gacttcccga     1560

gttgtgcaga gtgacgtctg tactttttat acttagaaca tttggtcaag ttttgtaacc     1620

aaaccttagg gaattgagag ggaaacttta tggtacgttt accttttttc ctttttatat     1680

gaattatttt gtacaaagtt cagagagcgg tacctttcct actgtctttt ctttgactcc     1740

atggaggaat ttgtaacgat cggtgtgacc tgaaagggtt tgtgatacag cggtcactat     1800

tttctcttaa cacataggaa aaaagttcag acatcgctac aataaatgtg ctttatttga     1860

tccaccaaa                                                             1869


<210> 3190
<211> 699
<212> DNA
<213> Homo sapiens

<400> 3190
gtacgggagc tggaggctga gcttgatgca gagcagaaga agcacgccga ggcccttaag       60

ggcgtgcgca agcatgagcg ccgtgtcaag gagctcgcat accaggtggg cgacagggtc      120

tccctgggga gtggccctgg agctggccca gcccaagcaa gccctgagtc ccccttgccc      180

gcccaggccg aggaggacag gaagaacctg gctcgcatgc aggacctggt ggacaagctg      240

cagagcaagg tcaagagcta caagcgccag tttgaggagg cggagcagca ggccaacacc      300

aacctggcca agtatcgcaa ggcccagcac gagctggatg atgcggagga gcgggcagac      360

atggcggaaa cccaggccaa caagctgcgg gcacggaccc gggacgccct gggccccaag      420

ctatcccttt ctcctcagca caaggagtga cggcctgacc ccctgggctc taaagaggaa      480

tgtctgctgt tgcacatctg gctgaggcca cctgccccga tcctgccatc tctgcatcgc      540

cccctgctgc cttcagcctt ccctgggccc tgaataaaca ccacagccag tttccttctc      600

attcttttct ttggggttca ggaggaaaaa cacagtccta gggacaaaag ccaggtccac      660

agcagtcatt tttaaaataa agttatttaa tagtctcca                             699


<210> 3191
<211> 3714
<212> DNA
<213> Homo sapiens

<400> 3191
ttatcagaga cattgagagg caaattcgga aaaaagaaaa cattcgtctt ttgggagaac       60

agattatttt gactgagcaa cttgaagcag aaagagagaa gatgttattg gcaaaaggat      120

ctcaaaaatc atgacttgaa tgtgaaatat ctgttggaca gacaacacga gtttgtgtgt      180

gtgtgttgat ggagagtagc ttagtagtat cttcatcttt ttttttggtc actgtccttt      240

taaacttgat caaataaagg acagtgggtc atataagtta ctgctttcag ggtcccttat      300

atctgaataa aggagtgtgg gcagacactt tttggaagag tctgtctggg tgatcctggt      360

agaagcccca ttagggtcac tgtccagtgc ttagggttgt tactgagaag cactgccgag      420

cttgtgagaa ggaagggatg gatagtagca tccacctgag tagtctgatc agtcggcatg      480

atgacgaagc cacgagaaca tcgacctcag aaggactgga ggaaggtgaa gtggagggag      540

agacgctcct gatcgtcgaa tccgaggatc aggcatcagt ggacttatcg cacgaccaga      600

gtggggattc cctcaacagt gatgaaggag acgtgtcttg gatggaggag cagctgtcct      660

acttctgtga caagtgccaa aaatggatac cagccagtca gctgagggaa cagctcagtt      720

accttaaggg tgataatttt tttaggttta cttgttcgga ttgctcagca gatggcaagg      780

agcagtatga aaggctgaag ctgacatggc agcaagtcgt catgttggca atgtacaact      840

tgtctctgga aggaagtgga cgtcaaggtt atttcaggtg gaaagaagat atctgtgctt      900

ttattgagaa acattggact tttttactag ggaataggaa aaagacgtct acctggtgga      960

gcaccgtggc aggttgcctc agcgtgggaa gtcccatgta cttccgttca ggtgctcagg     1020

aatttggaga gccaggatgg tggaaacttg ttcataacaa gcccccaacg atgaaacctg     1080

aaggagagaa gttgtctgcc tctactttga aaataaaagc agcctcaaaa ccaactttag     1140

atcccatcat tactgttgag ggacttagaa aacgagcaag tcggaatcct gtggaatctg     1200

ccatggaatt aaaagagaaa aggtctcgaa ctcaggaagc aaaagacatt agaagagccc     1260

agaaggaggc cgctggcttt cttgacagga gcacatcttc tacccctgta aaattcataa     1320

gccgaggccg caggccagat gtgattctgg aaaaaggcga agtgattgac ttttcctcct     1380

tgagctcctc tgaccgcacc ccgctgacaa gcccatctcc ttctccttct ctggatttct     1440

ctgcccctgg tacacctgcc tctcattctg ccacacctag cttgctttca gaagcagatc     1500

tgattccaga tgtgatgccc ccacaagcct tgtttcatga tgacgatgag atggaaggcg     1560

atggagtcat agacccaggg atggagtacg tcccaccccc tgctgggtca gtagcttctg     1620

ggccagtggt tggggtcaga aagaaggtca gaggccctga acagataaag caggaggtag     1680

agagtgagga ggaaaaaccc gacaggatgg atattgacag tgaagacaca gattcaaaca     1740

catctttgca aacaagggct agagaaaaga ggaagcctca gctggagaag gacacaaagc     1800

cgaaagagcc caggtatact cccgtgagca tctacgagga aaagctgctg ctcaagaggc     1860

tggaagcttg tcccggtgct gttgccatga ctccggaagc tcggagactg aaacgcaaac     1920

tgattgtcag acaagcgaaa agggataggg gattaccact ttttgacttg gatcaagttg     1980

ttaatgctgc tcttttgtta gttgacggga tttatggagc caaagaagga ggaatttcca     2040

gacttccagc tggacaagcc acgtacagaa ccacctgtca ggacttcaga atccttgacc     2100

gataccagac ttccttgccg tccaggaagg gatttcgaca ccagaccacc aagtttttgt     2160

atcgcttggt aggatcagaa gatatggctg tggaccagag tattgtcagc ccttatacct     2220

ctcggatctt gaaaccttat atcaggcgtg attatgaaac aaagccaccc aaactgcagc     2280

tcctgtcaca gattcgttcc cacctgcaca ggagcgaccc tcactggacg ccggagcccg     2340

acgcacctct cgattactgt tatgtgcggc caaatcacat cccaacgatc aactccatgt     2400

gtcaggagtt tttttggcct ggcattgacc tgtctgagtg tctgcagtac ccagacttca     2460

gtgttgttgt tctttataaa aaagtcatca ttgcctttgg cttcatggtt cctgatgtga     2520

aatacaatga agcttacatt tcatttctgt tcgtccaccc tgaatggaga agagcaggga     2580

ttgcaacttt catgatctat catctgattc agacctgcat gggcaaggac gtaacccttc     2640

acgtctcagc aagcaaccct gctatgctac tgtaccagaa gtttggattc aagactgaag     2700

aatatgtatt agatttctat gataaatatt acccattgga gagtacagag tgtaaacacg     2760

cattctttct gaggctccgg cgctgatgcg aatacagctc acagagaaac gcatgtgcta     2820

ttggagaaca ggtctttgtg gagatctaaa ggcagtgatt gatttcacag ggagctctaa     2880

tctctgtgat tacatggtcc ttcaaactcc caaccaaagt gagaaaagcg gcatgcagtg     2940

aaatgagcag tgagcagccc tttagcaaaa tcgccctcca gtccttcctg gagatgcctt     3000

cagccagcat cccagactcc acagttattt atgaatgatg tcgtgattct ccctccacct     3060

gacagtttgt aagagtgaaa gagcatctaa cctgatgctc ttggagagag ataacctgtc     3120

tgtcataact taaaggatga gaaaatgtgg tgtagctatt aaagattcat gcagtcccaa     3180

aaggcactgt cctgggatga tgagagatta taaggtgatt tcataaaagg aatccaaccc     3240

tgtgcccggc cattgatgtg ttgtcattga atccaggagg atttctaggg cactgaagtt     3300

ttgttgtttc ttttgctgac tttggttaca gtcagaaaaa ataaactaga tgtttgtgtc     3360

tacatgttct acctgttgta cctattagca tcttcctgca gggacttggg cccatggcct     3420

gggaggttgg tttgggattg gggttgttgg gcagcctgcc attcacctgg cctatcctgg     3480

cccttctcat gcccaagaca gttgtttcac aggagtggaa gtgtgggtga tgcaagtaga     3540

accctctaga tgtaccctgt gtggtctgca ggactggact gtttgctgtg tttgtggatg     3600

ttggcgatag actgtcaatt aggttgtttg tgatccaaca agaacatttc caaaagtatc     3660

taggtgttct caaataaaaa gctttctttg cacaacccat ggccagagcg tcaa           3714


<210> 3192
<211> 616
<212> DNA
<213> Homo sapiens

<400> 3192
agtgtaatca tcatctgctt tccacatata aaaatcacct tggttatcta tagttcaatc       60

ttctaaagcc ttcaagcctc tgaaattctt caaaattcag aagaagtaga aggaagtttt      120

tgatgatgag tgaggtggag gaagccatgc agtgtgtgga agagctgaat gcccagggcc      180

tactacatgt ttttgtgaga gtgggagtgg agtccaccct ggaaaggagc cagatcacca      240

gggatcacat gggccaatta ctctatcagc tggtacagtc agaaaaactc agcaaacagg      300

actttttcaa aggtttttca gaaactttgg aattggcaga tgacatggcc attgatattc      360

cccatatttg gttgtacctt gctgaactgg tgacccccat gttaaaagaa ggtggaatct      420

ccatgagaga acttaccata gaatttagca aacctttact tcctgttgga agagctgggg      480

tcttgctatc tgaaatattg cacctactat gcaaacaaat gagccataag aaagtgggag      540

ccttatggag ggaggctgac ctcagctgga aggacttttt accagaagga gaagatgtac      600

ataattttct tttgga                                                      616


<210> 3193
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3193
aacagaccgc cgtgagagag gaggggcgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg tgttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cgaagtcctc      180

accagtgaac ggagacctct ctgaactaag aataccatgg ccacgtcagc cccactacgg      240

agcctggaag aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc      300

attgactgtg gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg      360

agccgccccg tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg      420

tggcaactgg ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag      480

ccgggagagg tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag      540

ctgcactact actgtgagga cgacgggaag ctgctgtgcg tg                         582


<210> 3194
<211> 7211
<212> DNA
<213> Homo sapiens

<400> 3194
attcccctcc acttcttgcc tgagccgcct gctcctcttg gaaacacgtt gagcctcccc       60

gctggagagg gagccagaac agggaagaac ggattcacac aggatggctt gcagaagacg      120

ctatttcgtc gagggcgagg cccccagcag tgagactggc acatccctgg acagcccctc      180

agcctacccc cagggcccct tggtgcccgg ttccagcctg agcccggatc actacgagca      240

cacgtcagtg ggagcctatg ggctgtactc ggggccgccg gggcaacagc agcgcacgcg      300

gaggcccaag ctgcagcact cgacctccat cctgcgcaag caggctgagg aggaggccat      360

caagcgctca cgctcactct ccgagagcta tgagctctcc tcggacctgc aggacaagca      420

ggtggagatg ctagaacgaa agtatggggg gcgcctggta acccgccatg cggcccgcac      480

catccagacg gcgtttcgcc agtaccagat gaacaagaac ttcgagcgct tgcgcagctc      540

catgtcagag aaccgcatgt cacgccggat tgtgctgtcc aacatgagga tgcagttctc      600

ctttgagggg cctgagaaag tgcacagctc ctacttcgag gggaagcagg tctcagtgac      660

taacgacggc tcccagctgg gagccctggt gtcccctgag tgtggtgacc tcagcgagcc      720

caccaccctc aagtctccgg ccccctccag tgactttgcg gacgccatca ccgagctgga      780

ggacgccttc tctaggcaag tgaaatcact ggccgagtcc atcgacgatg ccctcaactg      840

ccgcagcctg cacactgagg aggcaccggc cctggatgcg gcgcgggccc gggacaccga      900

accccagaca gccctgcacg gcatggacca ccgcaaactg gacgagatga cggcctcgta      960

cagtgatgtc accctgtaca tcgatgagga ggagctgtcg ccccctctgc ccctctcgca     1020

ggcaggggac cggccgtcca gcaccgagtc ggacctgcgg ctacgggctg ggggcgcagc     1080

cccagactac tgggccctgg cccacaaaga ggacaaggct gacacggaca cgagctgccg     1140

gagcacgccg tcgctggagc ggcaggagca gcggctgcgg gtggagcatc tgccgctgct     1200

caccatcgag ccacccagcg acagctctgt ggaccttagt gaccgctcgg agcgggggtc     1260

actcaagagg cagagtgctt acgagcgcag ccttggcggg cagcagggca gtcccaagca     1320

tggtccccac agcggcgccc ccaagagcct cccccgggag gagcctgagt tgcggccccg     1380

gccccccagg cccctggaca gccacttggc catcaatggc tcagccaacc ggcagagcaa     1440

gtctgagtcg gactactcag acggtgacaa tgacagcatc aacagcacgt ccaactccaa     1500

cgataccatc aactgcagct ccgagtcatc gtcccgtgac agcctgcggg agcagacgct     1560

cagcaagcag acctaccaca aggaggcccg caacagctgg gactcgcctg cctttagcaa     1620

cgatgtcatc cgcaagaggc actaccgcat cggcctgaac ctcttcaaca agaagcctga     1680

gaagggagtc cagtacctca tcgagcgtgg ctttgtgccc gacacgcccg tcggggtggc     1740

ccacttcctg ctgcagcgca agggcctcag ccggcagatg atcggcgagt tcctgggcaa     1800

ccggcagaag cagttcaacc gtgacgtgct cgactgcgtc gtggacgaga tggacttctc     1860

taccatggag ctggatgagg ccctcaggaa attccaggcg cacatccgtg tccaagggga     1920

ggctcagaaa gtggagcggc tcatagaggc gttcagccag cgctactgca tctgcaaccc     1980

tggggtggtg cggcaattcc ggaacccaga caccattttc atcctggcct tcgccatcat     2040

cctgctgaac accgacatgt acagccccaa tgtcaagccc gagcggaaaa tgaagctaga     2100

ggacttcatc aagaacctcc gaggtgtgga cgatggtgag gacattcccc gtgagatgct     2160

gatggggatc tatgaacgga tccgtaagcg agagctaaag accaatgagg accatgtgtc     2220

ccaggtgcag aaggtggaga agctcattgt ggggaaaaag ccgatcggat ccctgcatcc     2280

cgggctcggc tgtgtgctct ctctgcccca ccgtcggttg gtctgctact gccggctctt     2340

tgaggttcca gacccaaaca agccccagaa actcggacta caccagcgag aaatcttcct     2400

gttcaacgac ctcctggtgg tcaccaagat cttccagaag aagaagaact cggtgacgta     2460

cagcttccga cagtccttct ccttgtacgg catgcaggtc ctgctcttcg agaaccagta     2520

ctaccccaat ggcatccggc tcacctcgtc tgtccccgga gcagatatca aagtgttaat     2580

aaacttcaac gcccccaacc ctcaagaccg gaagaaattc accgatgacc tgcgggagtc     2640

cattgcggaa gtccaagaga tggagaagca caggatagag tcggagctcg agaagcagaa     2700

aggcgtcgtg cggcccagca tgtcccagtg ctctagcctc aaaaaggagt cgggcaacgg     2760

aacactgagc cgggcctgcc tggacgacag ctatgccagc ggtgagggcc tcaagcgcag     2820

cgccctcagc agctccctgc gggacctctc ggaagccggg aagcgagggc gtcgcagcag     2880

tgcgggatcg ctagagagca atgtggaagg gtccatcatt agcagtcctc acatgcgccg     2940

gagagctaca tcaacacgag agtgtccatc tcgcccacac cagactatgc ccaactcatc     3000

ttccctcctg ggctccttat tcgggagcaa gagagggaag ccccctcccc aggcccacct     3060

gccctcagcc ccagccctgc caccccccca cccaccggtg gtcctgcctc acttgcagca     3120

ctctgtggct ggccaccacc tggggccccc agaggggctg ccgcaggccg ccatgcacgg     3180

gcatcacacc cagtactgcc acatgcagaa ccctcccccg taccaccatc accaccacca     3240

ccacccaccc cagcacatcc agcacgcaca ccagtaccac cacggccccc atgggggcca     3300

cccagcctac ggggcccatg cccacggcca cccgccgctg ccctcggccc acgtggggca     3360

cacagtgcac caccatgggc agccccctgc cccgccgccc cccaccagca gcaaggccaa     3420

acccagcggc atcagcacaa ttgtgtagac agcctgggta ggggtcccag gctccctgaa     3480

acacctgcac accacacagg gcacgcccgg gggtcgccag ccgcacacca aacccggggc     3540

acttctgttg ccatctctcc cctctgcccc tcacggccca accggagccc caggagccca     3600

cagggctggt gttgtgtgga acaaaggccc agatttcatt tcttgttggc accctgggct     3660

ctgctcacct cagtctgagg gatgggtggg cctcagacac catcagcctt gaaacggtga     3720

gccagccaag tagtgttgaa ctgcctcccc cactccagct ctcagctccc tgtgccctaa     3780

tgtacatgca tatgaaaacc caacctagaa aacgaagaaa tgagatacaa aaacagacaa     3840

aacaaacccc aaaacttgct gcattattgc tcttttattg acaatgggca aaaaaataag     3900

tagacctgat atggttgatg aaaatacgta agtaaacttt atataaatat ataaatatat     3960

aaatatatat atatatatac tgtataggta gtacttgtgt gtgaaaggca ggcgtttcag     4020

tccacattag caatacccac cttacaagga gctccactta cctaatagga agacagtacc     4080

ttagctgggt gtgtgagaca atagaccaaa ccctaaatgc taggaacaaa ttcagatact     4140

tcatattttc atacaaagaa gtccctctag gactggctaa aatctttaca caatcattac     4200

taactgtgcc aagtaacata gcatctaact gtttaaaaag tccagtattg ctttgtataa     4260

atccttattt tattaacaga atactatcat aaatagtatt ataatgctgt tatttcaggt     4320

aagcaaatag ctaaactgca gtacactcta cagtagcaac tcaggacagc tggttacaag     4380

ctggttgtct taggacattg gttacacgga ttcttagaca ctttaatggc tgcgataact     4440

gtgactctcc atgatccatg tttcttttat gcgcatatga tttgacgcac actcattcag     4500

agtcctccga gaggggcacc catacacggc agaagtgttc atctccaaca tgaaagtgac     4560

cagctctcat cctcgtctcc ccaacaccat aacgtcctca tcccgcctcc aacccacacc     4620

aggccgaagc cctcagagag tgttttcatc aggaaccact ctcgaacctg aaggttgact     4680

ttagcgttta gcaacccagg gcggtgtgtg tgtttcccgt tttgttttct gagtggtagc     4740

agtgatcacc gtaattccat gtagccatgt gctagcagaa cccctgtgtc ctcaccgtgg     4800

cccgtgtgac cccagccgac gagtgcccgg cggagccccc gctgccttcc catggtccag     4860

tgagctgcca gggcatcaca tgactctcag ctgtgctctt gtcgcttctg tgttgtggtg     4920

acaccatgcg ctccccaggg ccagacctgc acgcggcagg tctgtgcccg agtcacccac     4980

gggccatact ttgtagtttc agcctttcga gccactgcag ccgtcagtgc tgtgctccta     5040

agccatggga cccgaggact gccccccggc gcctgcccag gcggaggccc tttcagaaag     5100

ggcgaagctc acgcctgact ctgcgggccg cggggccgcg ttcccagtgg acagcgtggt     5160

gagccgtggc cggacggcag gaggagaggg gagccccctc tggctgtgtg tcaccttggc     5220

tggctggctg gccagggttt tgccgatttc cctcctcaca tccctcccac cctcggtcat     5280

atcattgaga tcaccgtacc agcaaatctg caaaccaagc actttgttaa tctccagaga     5340

gagcaaatac agcaatctag agtttagcct ttttaaaaat gtgactttaa cccgcccacc     5400

tgtgtcctcc cattggcgtg gcatttcttt ggtgtctgct cagaaagaaa cagcatggga     5460

ccgtgtgatt gggtccaggc tgggctgtca gggaagcgcc ctggtgtctc cgactcatca     5520

attctcgggt cttttttaaa agccaggctc cccaaagcac tctgtctcgc aattttgagg     5580

aggctgttcc gacctggaag cgttaaactg ctgcatgtca tctggcgtca gctgtgaggc     5640

tgcgctctgc gtgttgtgcg tttgcaaaat gtattggcgt gactgtaaac acatcgttga     5700

agtaaagcga ttacatattg agtatgtcag cttttctcac cctcttctgt gctgggagga     5760

gagtctaact gtaaccttta ggttgttcca gaaaagattc aggccgtttg gcacagaatt     5820

gctctttctg aagggtagca gtaatgaata ggaacagaca gaaaacccca ggaggggctt     5880

tcaggaaact ctccctctcc atcgccatcc tgcaagctcc acagcctcgg gctgccagcc     5940

tgtggcactg tcctcggtgt gtcctggagc tgtgctgggc agcagggcct cgcgtaagga     6000

actgctggaa cccactgagc ccttcccggg gtttcccgcc gcactcagtg tgttccttca     6060

ggctagtgag gtttcattct gttttatttg caagcttatc aaaagtttgt ggaagataca     6120

ttgttgggtt ccagaggctg gagtcatgct gcccacatct tgtttgggaa agcaaaagct     6180

cccagtgagc tggtgtcccc gtgtgtcttt catgggactg tcccctttag agatcccacc     6240

tgtcagagcc acagcttcgg ggtcctgtca tcacatcccc tgggagggga ggcaggagga     6300

ggccgagggc cccaggatgt ctgcctggtc ccttctcact gtgaggacgc ccttggcaca     6360

cctttctcaa gtcacacaaa ttactgcagt tacatacaga attgctgaca ggagcaggag     6420

acgctgaggg aaacagctgg caatgtgaca aaagtctttt ctgggacaac aatcaaatca     6480

tgtatttgta tttttttaag tttaccaatg aattgtacaa caatgtaaaa ataaagttca     6540

tcctaatatg ctgtgcacat cttgcttaaa aatgtcttca gcacccagtg cagtgatctt     6600

tccctcacac actgcatgca gcaggagcct cttgtttttc ttaatgagct gaaaagacag     6660

cagatgttca cagctgatgc tgggtgttga ctcagcgcca cgggaagctc tgtgcccgca     6720

ggtaagcacg cacagtctta cagttctcct tgtaaaatat catcaccctt cctgcctgag     6780

aaacgagtac atttgtattt tatgtaacaa caatagtcaa ggcagcattg caacactgag     6840

cagggtgagg tgggggtgct gagcacagga caagagggag gaggcctgcc ctccattcag     6900

atgcatctgc atcgcccttc tgtgtgcagt cacatcgaga ctgcacacag catgcatctc     6960

ctcttggaaa atatcttttg cctccgagtt gttttaagca attagaatca ggtcctgaat     7020

ccccagactg ttcagagact tcaagggaca cctccctcac aagaagcctg gcacccccac     7080

tgtgtacctt tgagaggaaa ggagtgcgtt tgttttcatc tgcattctgt ttgtcagtgg     7140

caacagactc tatcaatgta aaaccatggt tgtgatcatg tggggaaatc aaataaatcc     7200

tttgaaactc t                                                          7211


<210> 3195
<211> 975
<212> DNA
<213> Homo sapiens

<400> 3195
ggcgacgcct gcgcagtgcg gtcgcggggc tgtcgttgtc ccgcgagccg ccgaccaggc       60

ctcgaacggg atggcagagg aggtgagcac cctgatgaag gccacggtcc tgatgcggca      120

gcctgggcgg gtgcaggaga tcgtgggcgc cctccgcaag ggcggcggag accggttaca      180

ggtgatttct gattttgaca tgaccttgag caggtttgca tataatggaa agcgatgccc      240

ttcttcttac aatattctgg ataatagcaa gatcatcagt gaggagtgtc ggaaagagct      300

cacagcgctc cttcaccact attacccaat tgagatcgac ccacaccgga ccgtcaagga      360

gaagctacct catatggtgg aatggtggac caaagcacac aatctcctat gtcagcagaa      420

gattcagaag tttcagatag cccaggtggt tagagagtcc aatgcaatgc tcagggaggg      480

atataagacc ttcttcaaca cactctacca taacaacatt ccccttttca tcttttctgc      540

gggcattggt gatatcctgg aagaaattat ccgacagatg aaagtgttcc accccaacat      600

ccacatcgtg tctaactaca tggattttaa tgaagatggt tttctccagg gatttaaggg      660

ccagctcata cacacataca acaagaacag ctctgcgtgt gagaactctg gttacttcca      720

gcaacttgag ggcaaaacca atgtcatcct gctgggagac tctatcgggg acctcaccat      780

ggccgatggg gttcctggtg tgcagaacat tctcaaaatt ggcttcctga atgacaaggt      840

ggaggagcgg cgggagcgct acatggactc ctatgacatc gtgctggaga aggacgagac      900

tctggatgtg gtcaacgggc tactgcagca catcctgtgc cagggggtcc agctggagat      960

gcaaggcccc tgaag                                                       975


<210> 3196
<211> 1577
<212> DNA
<213> Homo sapiens

<400> 3196
gttgctcctt cagcgcctat cgctggctct tggggcgcag agaggggccg cagtctccgc       60

ggctgcgtcg agctcccttg cagtcccctc catgttcccc ggcgccacta ctccccttcc      120

taaggccgcc gcttaccccg gggtctatgg aagtaatgga aggacccctc aacctgcata      180

tctttctgaa gccatgaagc tgacacagtc agagcaggct catctttcac tggaattgca      240

aagggatagc catatgaaac agctcctcct catccaagag agatggaaaa gggcccagcg      300

tgaagaaaga ttgaaagccc agcagaacac agacaaggat gcagctgccc atcttcagac      360

atctcacaaa ccctctgcag aggatgcaga gggccagagt cccctttctc agaagtacag      420

cccttccaca gagaaatgcc tgcctgagat tcaggggatc tttgacaggg atccagacac      480

actactttat ttacttcagc aaaagagtga gccagcagag ccatgtattg gaagcaaagc      540

cccaaaagat gataaaacaa ttatagagga gcaggcaacc aaaattgcag atttgaagag      600

gcatgtggaa ttccttgtgg ctgagaatga aagattaagg aaagaaaata aacaactaaa      660

ggctgaaaag gccagacttc taaaaggtcc aatagaaaag gagctggatg tagatgctga      720

ttttgtagaa acgtcagagt tatggagctt gccaccacat gcagaaactg ctacagcctc      780

ctcaacctgg cagaagttcg cagcaaatac tgggaaagcc aaggacattc caatccccaa      840

tcttcctccc ttggattttc catctccaga acttcctctt atggagctct ctgaggatat      900

tctgaaagga tttatgaata attaaaatgg aaggccacag aaaaggggaa aagaggaaat      960

aatacagtaa tcgttaatcc agcaaaaaga aatgaaaagg gaaaaccaca tagaagggta     1020

atcccggaaa tgcttcatct ggtggactgt gggagcagag gcattgccag gacttgggaa     1080

acagtcactg tgaaatgcgc tgcgtatctc attcactcac ttcagctaat gattccgact     1140

tggcagacgc taaactcatg gaggttcggt ttctcctgat acaaaccaaa tggctacctg     1200

gaagaatttc tttcaagcaa cagttatttt tcttatcttc agggttaaaa tgtataaaag     1260

ttatgtgtaa ttaatctata atgccataaa tgataatgca aaacctaaat aatatggtgg     1320

ccggaggggc tgccttatat ttgaaacatg ctttctatca tgcattgact gtatgcattt     1380

tgttaatgca cattctgttt gtttaaggtg tgtaagatac acacccttct agatgaaact     1440

atatgtgcca cactttgcac tactcataat gataacctca agactatcag aagaaatatt     1500

taaatttcca ttttatgaag aaaggaacca aattattatg ctttttaaaa caaattacca     1560

gtttacataa ttaatca                                                    1577


<210> 3197
<211> 390
<212> DNA
<213> Homo sapiens

<400> 3197
ctgtgcggct gcaggaacct aggaaataac tcggaacctg taacgtccca ctggtttgga       60

catattcctc tcctgatctg gcctcatctg ttccagggag gtgggattga gcctagtgca      120

ggctacagtc aaacctcttc tggacttctg cgacagcctt ttatttggtt tcttgccgct      180

ccttgacctc taacattctc gtctctgcac tgcagctaac atgatcgtca aacacaaatc      240

agaacatatg cagtaatgtc acctcaaaag agagttaaga acgtccaggc acaaaacagg      300

acttcacaag gtagtagtag ttttcagacc acgctttcag cctggaaagt aaaacaggat      360

ccaagcaact cgaagaacat ctcaaaacat                                       390


<210> 3198
<211> 1700
<212> DNA
<213> Homo sapiens

<400> 3198
gcggaagggg ttcgcacgcc aagaaccgcc atgcctgggg atcaccgccg catccgcggc       60

cctgaagaat cgcagccgcc gcagctgtac gcggccgacg aggaggaggc gcccggcacc      120

cgcgacccaa cgcggctacg gcccgtgtac gcgcgcgccg ggctgctgag ccaggccaag      180

ggctcggcct acctggaggc gggaggcacc aaggtgctgt gtgccgtgtc gggcccgcga      240

caggccgagg gcggcgagcg cggcggcggc ccggccggag caggcggcga ggccccggcc      300

gcgctgcgcg gtcgcctgct ctgcgacttc cgccgcgcac ccttcgcggg ccgccggcgc      360

cgcgctcccc cgggcggctg cgaggagcgt gagctggcgc tggcgctgca ggaggcgctg      420

gagccggctg tgcgcctggg ccgctacccg cgcgcgcagc tcgaggtgtc ggcgctgctg      480

ctggaggacg gtggctcggc cctggccgcc gcgctcaccg ccgccgcgct cgccctggcc      540

gacgcgggcg tggagatgta cgacctggtg gtgggctgcg gcctcagcct cgcgccgggg      600

cccgcgccca cctggctcct ggaccccacg cggctcgagg aagagcgcgc cgccgccggc      660

ctcaccgtgg cgctcatgcc tgtgctgaat caggtggccg ggctgctggg cagcggcgag      720

ggcggcctga cagagagctg ggcggaggcc gtacgcctgg gcctcgaggg ctgccagcgc      780

ctctaccccg tgctgcagca gagcctggtg cgggccgccc gccgcagggg cgccgccgcc      840

cagccctgaa ccagaagcct gagcaactac ggacgcaagc cgaggaccgt gctgccgccg      900

tccacgaaaa gacccgcgcc atcggcctcc agtttgcgtc gagaattcct ggaagggccc      960

tgatatgact gtggttggac tgacctgact gccagatggt gggacttggt ctggagcagg     1020

gactacttgg aatgataaag gcaaaactca acagcccctg gagctgcgct tgtggtggag     1080

ctggaccctg aaattacctg gacctttttt ttagagacag ggtttctttc tgcagtctca     1140

aactcctagc cttgattgat cctcctgcct tggcctccca aagtgctggg actacaggtg     1200

catgcaacca cacctggcta attttctttt cttctttctt tctttttttt tttttttttt     1260

ttttgatgga gtcttgttct gttgcccagg ctggagtgca atggtgcaat cttggctcac     1320

tgcaacctct gcctcctggg ttcaatccat tctcctgcct cagcctccca agtagctggg     1380

attacaggca catgcctcca taccgggcta atttttgtat ttttagtaga gatggggttt     1440

cgccatgtgg gccaggctgt tctcgaatgc ctgacctcag gtgatccacc cgccttggcc     1500

tcccaaagtg ctggaattac aggtgtgagc cactgtgccc agctgagtaa atttcttgat     1560

tgcacagaat gtacggtgat attggcggac ttaaggacat cgaattgttt atcaggaata     1620

aagtattatg tgtgttttct gcggccctgg ataatgctgt agcattcagg gtcgattgag     1680

taaaaaaaat gtagagatgg                                                 1700


<210> 3199
<211> 710
<212> DNA
<213> Homo sapiens

<400> 3199
gctcgtccgc tccctccccc gcgccgtgca cgtcttggtt cgggccgggc ataaaaggct       60

tcgcggccca gggctcactt ggcgctgaga acgcgggtcc acgcgtgtga tcgtccgtgc      120

gtctagcctt tgcccacgca gctttcagtc atggcctccg gtaacgcgcg catcggaaag      180

ccagcccctg acttcaaggc cacagcggtg gttgatggcg ccttcaaaga ggtgaagctg      240

tcggactaca aagggaagta cgtggtcctc tttttctacc ctctggactt cacttttgtg      300

tgccccaccg agatcatcgc gttcagcaac cgtgcagagg acttccgcaa gctgggctgt      360

gaagtgctgg gcgtctcggt ggactctcag ttcacccacc tggcttggta tgagcagggg      420

ccaaagaggg aggttgcagc taagctcaca ccctcaggtc ctagcagtgt ggcttcgtgg      480

ccattgctca acctctggaa cctgcgtttc cccatcgtga aaataatgga aacattgccg      540

cccaagtctt taaggatgat gacagtaatt agcatttgac aactagttgc ctggtatata      600

gagttgcaga tgcaactcag atgcaactct atctactcta tgtacttagt tcccaggagg      660

gaggctgtgc tgccctattt catgaagatg gaaactccag ttcaccgaag                 710


<210> 3200
<211> 1731
<212> DNA
<213> Homo sapiens

<400> 3200
agttggaaga ggcgagtccg gtctcaaaat ggaggtaaaa ccgccgcccg gtcgccccca       60

gcccgactcc ggccgtcgcc gtcgccgccg gggggaggag ggccatgatc caaaggaacc      120

agagcagttg agaaaactgt ttattggtgg tctgagcttt gaaactacag atgatagttt      180

acgagaacat tttgagaaat ggggcacact cacagattgt gtggtaatga gagaccccca      240

aacaaaacgt tccaggggct ttggttttgt gacttattct tgtgttgaag aggtggatgc      300

agcaatgtgt gctcgaccac acaaggttga tgggcgtgta gtggaaccaa agagagctgt      360

ttctagagag gattctgtaa agcctggtgc ccatctaaca gtgaagaaaa tttttgttgg      420

tggtattaaa gaagatacag aagaatataa tttgagagac tactttgaaa agtatggcaa      480

gattgaaacc atagaagtta tggaagacag gcagagtgga aaaaagagag gatttgcttt      540

tgtaactttt gatgatcatg atacagttga taaaattgtt gttcagaaat accacactat      600

taatgggcat aattgtgaag tgaaaaaggc cctttctaaa caagagatgc agtctgctgg      660

atcacagaga ggtcgtggag gtggatctgg caattttatg ggtcgcggag ggaactttgg      720

aggtggtgga ggtaattttg gccgtggtgg aaactttggt ggaagaggag gctatggtgg      780

tggaggtggt ggcagcagag gtagttatgg aggaggtgat ggtggatata atggatttgg      840

aggtgatggt ggcaactatg gcggtggtcc tggttatagt agtagagggg gctatggtgg      900

tggtggacca ggatatggaa accaaggtgg tggatatggt ggaggtggag gatatgatgg      960

ttacaatgaa ggaggaaatt ttggcggtgg taactatggt ggtggtggga actataatga     1020

ttttggaaat tatagtggac aacagcaatc aaattatgga cccatgaaag ggggcagttt     1080

tggtggaaga agctcgggca gtccctatgg tggtggttat ggatctggtg gtggaagtgg     1140

tggatatggt agcagaaggt tctaaaaaca gcagaaaagg gtaggtatct ttaaattttt     1200

attatgatga taaaagaata tgtggaactg ttcactgagt gtaataattt ttttatcctg     1260

tattattcaa caggctacag ttcttagcag gagagagagc gaggagttgt caggaaagct     1320

gcaggttact ttgagacagt cgtcccaaat gcattagagg aactgtaaaa atctgccaca     1380

gaaggaacga tgatccatag tcagaaaagt tactgcagct taaacaggaa acccttcttg     1440

ttcaggactg tcatagccac agtttgcaaa aagtgcagct attgattaat gcaatgtagt     1500

gtcaattaga tgtacattcc tgaggtcttt tatctgttgt agctttgtct ttttcttttt     1560

cttttcatta catcaggtat attgccctgt aaattgtggt agtggtacca ggaataaaaa     1620

attaaggaat ttttaacttt tcaatatttg tgtagttcag tttttctaca ttttagtaca     1680

gaaactttaa caaaatgcag tttcgaaggt gtttccttgt gagttaacaa g              1731


<210> 3201
<211> 319
<212> DNA
<213> Homo sapiens

<400> 3201
tatccatgag cagtgggaaa aggctaatgt aagcagtccc caccgggagt tcccccctgc       60

taccgccaga gaggtggacc cactccggat tcctccacac cacccacaca ccagtcggca      120

gcctccctgg cctcggagag gtggcatgat tgtggatccc ctgagatctg gcttcccaag      180

agcacttatt gacccttcct caggcctccc gaaccgactt cctccaggcg ctgtgccccc      240

aggagctcgc tttgacccct ttggacccat tgggaccagc ccacccggac ctaacccaga      300

ccatctcccc ccgccgggc                                                   319


<210> 3202
<211> 647
<212> DNA
<213> Homo sapiens

<400> 3202
agtggcaagc gcgggcagga ccgcgttgcg tcatcggggc gcgcgcctca gagagagctg       60

tggttgccgg aagttgagcg gcggatccaa ttcctgtatc ttcaccttgt ctaccgggat      120

ttctagagca gccttgtgag agacatttct gagacctgta tgtcctgcgt ctatgattct      180

tccctgatca aggcttctca aaccccataa tgctggtatc cagtgcatcc gttctcaaaa      240

actgaagctg atggacacca gattgcatgt gaaggtgaag gatattatag cagaaggaaa      300

ccaaaataaa agaaaaacag ctcctggaag taaccaatga gaaggacaga taagagtttg      360

aagactgtgg atgtgactgc ttgttccctg gttgacacac tgaagaagaa atcatgttga      420

ttcagagttg gcttggaggc aagaaataat ggcggcagct acgggggatc ctggactctc      480

taaactgcag tttgcccctt ttagtagtgc cttggatgtt gggttttggc atgagttgac      540

ccagaagaag ctgaacgagt atcggctgga tgaagctccc aaggacatta agggttatta      600

ctacaatggt gactctgctg ggctgccagc tcgcttaaca ttggagt                    647


<210> 3203
<211> 2595
<212> DNA
<213> Homo sapiens

<400> 3203
acttctcaat tctttgttct gtgaagtggt tgtcactatt gttcccattt tacagatttg       60

aggaactgat accccaagac cccgtgactt tctcaaggcc attccaagat ccctagatgc      120

acttacgctt aatgaactaa ttcttcacag cgaggcttct tgcttaaaat ccaagaaaat      180

accagataaa gggcattcta aatatatttc ttttctatag atgtggatct cctgttactg      240

gaaaacagga attagcttgt ctgcttgagg atgtggttgg ttctttataa aaaggataca      300

gaagaaattt gcacagactg ccagcttcat tatgctgccg acagcttcca gcaaaaggag      360

gacgtttgca gccagatatt tcacccgctc caaaagccta gtgatggggg agcagagccg      420

gagccctggg cggatgccgt gccctcacag gctgggcccc gtgctgaagg cgggctggct      480

gaagaagcag aggagcatca tgaagaactg gcagcagcgc tggtttgtgc tgcgtgggga      540

tcagcttttc tactacaagg acaaagatga gatcaagccc cagggattta tttctctaca      600

agggacacag gtgactgaac ttcctcctgg ccccgaggac ccagggaagc acctctttga      660

gatcagccca ggtggtgccg gggagcggga gaaggtgccg gccaaccccg aggcgctcct      720

gctcatggcc agctcccagc gtgacatgga ggactgggtg caggccatcc gccgagtcat      780

ctgggccccg ctgggcggag ggatctttgg gcagcgccta gaggaaacag tccaccacga      840

gcggaagtat ggcccccgcc tggcgcccct gctggtggag cagtgtgtgg acttcatccg      900

ggagcgcggg ctcactgagg aggggctgtt ccgcatgcca ggccaggcca acctggtgag      960

ggacctgcag gattccttcg actgtgggga gaagccactg tttgacagca caacagacgt     1020

gcacacggtg gcctccctgc tgaagctgta cctgcgggag ctccccgagc ccgtggtccc     1080

cttcgccagg tacgaggact tcctcagctg cgcccagctg ctcaccaagg acgaggggga     1140

gggcactctg gagttggcta aacaagtgag caaccttcct caggcaaatt acaacctgct     1200

cagatacatc tgcaagtttc tggatgaagt tcaggcatac tcaaatgtca acaagatgag     1260

tgtccagaat ctggcaaccg tttttggacc taacattctg cggccacagg tagaggaccc     1320

agtaaccatc atggaaggca cttccctcgt ccagcacctg atgaccgtcc tcatccgcaa     1380

acacagccag ctcttcacgg caccggtccc ggaagggccc acctccccgc gcgggggcct     1440

gcaatgcgca gtggggtggg gctccgagga ggtcaccagg gacagccaag gagagcccgg     1500

cggccccggc ctgcccgcgc acaggacctc ttccctggac ggggcggccg tggcggtgct     1560

ctccagaaca gcccccacgg ggccggggag ccggtgcagc cctgggaaga aggtgcagac     1620

cctgcccagt tggaagtcct ccttccggca gccgaggtcc ctatcgggaa gcccgaaggg     1680

gggcggctca tccctggagg tgcccatcat ctcctccggc gggaactggc ttatgaacgg     1740

gctgtcctcc ctgcgcggac accgccgggc ctcgtcggga gaccggctca aggactcggg     1800

ctccgtgcag agactctcca cctacgacaa tgtgcccgcg ccgggcctgg tccccggcat     1860

acccagcgtg gccagtatgg cgtggtccgg ggcctcgtcc agcgagtcgt cggtgggggg     1920

ctcactcagc agctgcacgg cctgccgcgc cagcgactcg tctgcccgca gttccctgca     1980

caccgactgg gccctggagc cctccccgct ccccagcagc agcgaggacc ccaagtccct     2040

ggacctggac cacagcatgg acgaggcggg cgcgggtgcc agcaacagcg agcccagcga     2100

gccggacagc cccacccggg aacacgcgcg ccgctccgag gccttacagg ggctggtcac     2160

tgagctcagg gccgagctgt gccgccagcg gactgagtac gagaggagtg tgaaaagaat     2220

cgaagaaggg agtgctgacc tgagaaaacg aatgtcccgg ttagaagaag aactggacca     2280

ggaaaagaaa aaatacatca tgctggaaat aaagctgcgg aactctgaac gggcgcggga     2340

ggatgcggag aggaggaacc agctgttgca gagggaaatg gaggagtttt tttcgaccct     2400

aggaagcttg actgttgggg caaaaggtgc cagggcccca aagtaaaagg aatggcagag     2460

ctcacttctg taccacgtct gctggtctcc agccttgtat ggagttagaa gcgtctgtat     2520

ctctggagca gccaggcgct ctggagccag ctggagagag agagatcctg atacctctgt     2580

ggggactgtg gggac                                                      2595


<210> 3204
<211> 890
<212> DNA
<213> Homo sapiens

<400> 3204
taggaattag ggcagagtta ggagcggcct gcggaggggc ccgctcaggc cgatgccggt       60

agtggaaaca gaggaagcca ccgccgcgct cttctcggaa ctggctaaaa tagctccgta      120

aatgggccga gcgcaacacg gaggggatac cgctcactac caggttcccg aactttggct      180

taccctcagc ttgagccagc gcacatctcc tccttaacag cctctcctga gaataggctg      240

gcttcaaggg aatgggggaa gtgaatgatc tcaaactaca gaaatggcag tgaacttgtc      300

tgtttcaatt cgggagtggg ctgcttcctg attggctgtg attgggcttt cactgtgctt      360

gtgaacacct tcttcagctt ccttcgacgc aaaacagact ttttcattgg aggagaagaa      420

gggatggcag agaagcttat cacacagact ttcagccacc acaatcagct ggcacagaag      480

acccggcggg agaagagagc ccggcaggag gccgagcggc gggagaaggc ggagcgggcg      540

gccagactgg ccaaggaagc caagtcagag acctcagggc cccagatcaa ggagctaact      600

gatgaagagg cagagaggct gcagctagag attgaccaga aaaaggatgc agagaatcat      660

gaggcccagc tcaagaacgg cagccttgac tccccaggga agcaggatac tgaggaagat      720

gaggaggaag atgagaagga caaaggaaaa ctgaagccca acctaggcaa cggggcagac      780

ctgcccaatt accgctggac ccagaccctg tcggagctgg acctggcggt ccctttctgt      840

gtgaacttcc ggctgaaagg gaaggacatg gtggtggaca tccagcggcg                 890


<210> 3205
<211> 1811
<212> DNA
<213> Homo sapiens

<400> 3205
agacggcagg gcttaaagtt ccgggaatca aagatcaact cccactgagg acaaatggac       60

ctgtaattcc gggtgtgacg agagaacgag atttaccttc ctgaattaaa aaacagactc      120

cctgcgacaa ggactgtgta ctgcatgaat gaggctgaga tagttgatgt tgctctggga      180

atcctgattg agagccgcaa acaggaaaag gcctgcgagc agccggccct ggcgggggct      240

gataacccag agcactcccc tccctgctcc gtgtcgcctc acacaagttc tgggagcagc      300

agtgaggaag aggacagtgg gaaacaggca ctggctccag gcctcagccc ttcccagagg      360

ccggggggtt ccagctctgc ctgtagcagg agccctgagg aggaggagga agaggatgtg      420

ctgaaatacg tccgggagat ctttttcagc tagggcataa actgtgcact gaactgtctg      480

ccgagagcag ctggaggaca gctgagcttc cactggtgct gctgggccgc ccgcctgtgg      540

gaatggggct ctctgtgctc ctacctttgt gccttcttgg gcctggcaga ttcacctcag      600

gccagaagcc cctggacact ccgggccttg gggctgccgt tctgagtgtg cggaaggcag      660

gactcaaaat gagatcccat ttgactccct ctgtatgtac tgtgccctct cctggctctt      720

gaggctctgg agtcccaatt gtctgtgtta gtcagtgacc aggttccagg gaaaatgatg      780

tcatgtggtg gtccaactta ctggaaccaa agagacagta ctttgcaaag aaaaggatca      840

ctgccaggtg cactggaatt gctacagttt agtccgcatg atctctcctg aaggaggaag      900

cctgtttcaa aaatagtttc catcatgagt ctatcaatga gctcccacct ctccagccag      960

cctagaaagc aaacgagctg cccacagttc tctgccctgt ctgggaggtt gaggccacag     1020

tgtatagact ggtaagccag acaggcctcc tcccgcaagc tgctaccttg ctttcacctg     1080

taccttggtc cccgggcagc tagctataaa gcaagaggga caggagccca gaagagacac     1140

tgaggacaag agatcacacc agagtacatg tctctgcctc tgttttcagt gtggctttgg     1200

acaggaatat atgaataaat cactgccata caggttttcc aatacacaag tgctagaaaa     1260

tacacacaat tccccaatgc gtaagttgtg ctaatgtctt tccaagttct gggttgggaa     1320

gtggagggtg gcagcgtttg tttgtgtgca gccgtccagt cctgttcaca gcgaggattt     1380

ggagtcctcc agggtctcat catgggagtg atttgtcagc ggacgcctct gccctgtctg     1440

gcttcaggtc cagggaagct ttgaagcagt caagccttgt ctttgtaccc catgtgtcct     1500

gtctttgttg agtcactcag agatcactcc tggacctctg gggttggagt tccagtgatg     1560

gcttatggcg gcccactcac tatggtgggc tgagtggaag ctccttaacc atgtccccag     1620

agacactgag gtgctcgctc ttttaatgtc ctcgtttgtt gccgtaagtt ctttgctagg     1680

tttcattttg gcatttggca aatcagcctg gaagtctggc cccatgacag caatcactcc     1740

ctccccaccc tcctgaagct agaggaagat ttgctcagat ccattaatta aagcaggaat     1800

tggtgtgaca a                                                          1811


<210> 3206
<211> 434
<212> DNA
<213> Homo sapiens

<400> 3206
tgatacaatc tggtgattcc cgagcataca catcatattt tatccccatt ttgccaatga       60

ggaaactgag acccagatct gccggaggcg ctgggcaatg accccgggac tccaggccag      120

aggggtctga agctgtttgg gaaagcagcg ggactccttg ggaagatggc catggcccca      180

agcccttccc tggtgcaggt gtacaccagc cccgcggctg tggccgtgtg ggaatggcag      240

gacgggctgg gcacctggca cccctacagt gccaccgtct gcagcttcat cgagcagcag      300

tttgtccagc agaagggcca acgttttggg cttgggagcc tggcccacag catccccttg      360

ggccaggcag acccctcgct ggccccttac attattgacc tccccagctg gacccagttc      420

cgccaggaca ccgg                                                        434


<210> 3207
<211> 333
<212> DNA
<213> Homo sapiens

<400> 3207
acggggctct gggagtaagc ctgtctgcct ggcgggcctt caggtgcggc gtgagagatg       60

gatgccaatt caaaagacaa gccccctgaa accaaggagt ctgcaatgaa taatgctgga      120

aatgcctctt tcattttggg aactgggaag attgtgactc ctcagaagca tgccgaatta      180

cctcctaatc cttgcacacc agatactttt aaatcacctt tgaacttttc cacagtaacc      240

gtagagcaat tgggaattaa ttgacatttc ctgcagagtc tgtggcaaga gggaaagtaa      300

ccatctatgc tgaaatgatc tgtctagttc cca                                   333


<210> 3208
<211> 1001
<212> DNA
<213> Homo sapiens

<400> 3208
cggagacggt ggagtctccg cactgtcggc ggggtacgca tagccgggca ctaggagctt       60

tctcttgcat accctcgctt aggctggccg gggtgtcact tctgcctccc tgccctccag      120

accatggacg gctccttcgt ccagcacagt gtgagggttc tgcaggagct caacaagcag      180

cgggagaagg gccagtactg cgacgccact ctggacgtgg ggggcctggt gtttaaggca      240

cactggagtg tccttgcctg ctgcagtcac tttttccaga gcctctacgg ggatggctca      300

gggggcagtg tcgtcctccc tgctggcttc gctgagatct ttggcctctt gttggacttt      360

ttctacactg gtcacctcgc tctcacctca gggaaccggg atcaggtgct cctggcagcc      420

agggagttgc gagtgccaga ggccgtagag ctgtgccaga gcttcaagcc caaaacttca      480

gtgggacagg cagcaggtgg ccagagtggg ctggggcccc ctgcctccca gaatgtgaac      540

agccacgtca aggagccggc aggcttggaa gaagaggaag tttcgaggac tctgggtcta      600

gtccccaggg atcaggagcc cagaggcagt catagtcctc agaggcccca gctccattcc      660

ccagctcaga gtgagggccc ctcctccctc tgtgggaaac tgaagcaggc cttgaagcct      720

tgtccccttg aggacaagaa acccgaggac tgcaaagtgc ccccaaggcc cttagaggct      780

gaaggtgccc agctgcaggg cggcagtaat gagtgggaag tggtggttca agtggaggat      840

gatggggatg gcgattacat gtctgagcct gaggctgtgc tgaccaggag gaagtcaaat      900

gtaatccgaa agccctgtgc agctgagcca gccctgagcg cgggctccct agcagctgag      960

cctgctgaga acagaaaagg tacagcggtg ccggtcgaat g                         1001


<210> 3209
<211> 620
<212> DNA
<213> Homo sapiens

<400> 3209
ccttctctct tcctcggcgc tgcctacgga ggtggcagcc atctccttct cgcttgctcc       60

gtagctggcg attggaagac actctgcgac agtgttcagt ccctgggcag gaaagcctcc      120

ttccaggatt cttcctcacc tggggccgct tcttccccaa aaggcatcat ggccgccctc      180

agaccccttg tgaagcccaa gatcgtcaaa aagagaacca agaagttcat ccggcaccag      240

tcagaccgat atgtcaaaat taagcgtaac tggcggaaac ccagaggcat tgacaacagg      300

gttcgtagaa gattcaaggg ccagatcttg atgcccaaca ttggttatgg aagcaacaaa      360

aaaacaaagc acatgctgcc cagtggcttc cggaagttcc tggtccacaa cgtcaaggag      420

ctggaagtgc tgctgatgtg caacaaatct tactgtgccg agatcgctca caatgtttcc      480

tccaagaacc gcaaagccat cgtggaaaga gctgcccaac tggccatcag agtcaccaac      540

cccaatgcca ggctgcgcag tgaagaaaat gagtaggcag ctcatgtgca cgttttctgt      600

ttaaataaat gtaaaaactg                                                  620


<210> 3210
<211> 1709
<212> DNA
<213> Homo sapiens

<400> 3210
agtgcctgcg gccctcggcg gcctagtaca cacgcacctg agtgagtggc accagaggac       60

cctctccatg tttagggacc tcctgggcct caggagcgtg gcgcccgccc ctgggcggac      120

tccccccatc cgcgggcgcg aatggtccgg gccgcgtccg cagtgctgct ggctgctccc      180

tggttgctgg gtgcaaagtg ctgggttctg ggtttctgga ttcgcgggcc gttcacacgt      240

agcctgtgcc ggctcctcgg atgcaccgcg cgcccccgcg ccctcaccga cgggtccaga      300

cctggtggga agaaggtgcg gggacgggtc cctgaggatc ccgatgccta cgagccaaga      360

tgctcagctt tataggtgtg acctacacat gtgacttcac ctcagttttg tgatccgtaa      420

aatggacaaa ttcgaagcta cttcacagtg ctgttgagag gattaaatga aacaatgctt      480

gtaaagctct ttgcaggagg gagcctcgga agcagggcct ggccggcaga gcacacctgc      540

tgtcaccagg gaccacaggc agcatgaaga cccccgtgga gctggccgtc agtgggatgc      600

agaccctcgg ccttcagcac cgctgccgag gtggctaccg ggtcaaggcc aggacgtcat      660

atgtggatga gactctgttt ggcagcccag caggcacccg gcctacccca ccggacttcg      720

atccgccctg ggtggagaag gctaacagaa ccagaggcgt gggcaaggag gcatcgaagg      780

ccttgggggc aaaggggagc tgtgagacca ccccctcaag gggcagcacc cccaccctca      840

caccaaggaa gaagaacaaa tacagaccca tcagccacac cccgtcttac tgtgatgagt      900

cgctgtttgg ctcccgatct gaaggcgcca gcttcggggc cccgcggatg gcgaaggggg      960

atgccgcaaa gctccgtgct ctcttgtgga cgccaccacc tacccccagg ggtagccact     1020

cgccccgccc cagggaggca ccactgcgag ccattcaccc agctggtccc tccaagacag     1080

agccggggcc agcggcagac tcccagaagt tatctatggg tgggttacac tcttcacgcc     1140

ccctgaagcg gggactttcc cattccctca cccacctgaa tgtccccagc actggtcatc     1200

cagccaccag tgccccccac acaaatgggc ctcaggatct caggccttcc acgtcagggg     1260

tgaccttccg gagccccctg gtgacttcca gggctcgctc agttagcatt tcagtgccat     1320

ctaccccacg acgaggtggg gccacccaga aaccaaagcc cccttggaaa tgatactctt     1380

tcatcagggt tgcctatggg gccacggcga caggtatggc cccttgccag ggtaggagga     1440

cattcatcac ccagggaacc ccaggtatta aagaagcccc tgtgggggca gacagacata     1500

gcaggggtgg gcagtgcctc cctttatcct gacaatctct agtcgattct tgcctttttc     1560

tcccgattgc ggatttgggg gccacctcta agatgcctct ctccagccct gtctcaacca     1620

tactccaaat tagtgccaac ccaggggcct ggcacctccc acatcatcca ttgtcttgct     1680

gccaagtgcg aataaacggc gtgattgcc                                       1709


<210> 3211
<211> 1732
<212> DNA
<213> Homo sapiens

<400> 3211
agctggccgg gacccgggcg gagcgggcgg ggacccgggc tactgcggtg tggactcgag       60

ggctgggcgc ggggccggcg cagaagccgc cagctggaga cgatggtgga ccacttggcc      120

aacacggaga tcaacagcca gcgcatcgcg gcagtggaga gctgcttcgg ggcctcgggg      180

cagccgctgg cgctgccagg ccgagtgctg ctgggcgagg gcgtgctgac caaagagtgc      240

cgcaagaagg ccaagccgcg catcttcttc ctctttaacg acatcctggt gtatggcagc      300

atcgtgctca acaagcgcaa gtaccgcagc cagcacatca tccccctgga ggaggtcaca      360

ctggagctgt tgccggagac gctgcaggcc aagaaccgct ggatgatcaa gacggccaag      420

aagtcctttg tggtgtcggc cgcctccgct acggagcgcc aggaatggat tagccacatc      480

gaggagtgcg tgcggcggca actgagggcc acgggccgcc cgcccagcac ggagcacgcg      540

gcaccctgga tccccgacaa ggccacggac atctgcatgc gctgcacgca gacgcgcttc      600

tctgccctca cgaggcgcca ccactgccgc aagtgcggct tcgtggtctg cgctgagtgc      660

tcgcgccagc gcttcctgct cccgcgcctg tcccccaagc ccgtgcgcgt ctgcagcctc      720

tgctaccgcg aactggccgc ccagcagcgg caggaggagg cggaggagca gggcgcgggg      780

tccccagggc agccagccca cctggcccgg cccatctgcg gagcgtccag tggagatgac      840

gatgactccg acgaggacaa ggagggcagc agggacggcg actggcccag cagcgtggag      900

ttctacgcct cgggggtggc ctggtctgcc ttccacagct gacccccggc ctgcagaaca      960

tctgtcccca agccagctcc actgcccagg cccccaagag ggcagctcca gaagctgccc     1020

agggctccgg gaccccatcc catggtggca ggtgcagcgg tggggagtgg ctctttctgg     1080

actcccagtg cctttttgct ggacactgtg tccttatggc ttcactgcag gtaatgcctt     1140

tcccttcagg aagccccaga acacccacag gtcttggtaa caaacgccac cttacactct     1200

gcaggctgca gcggcagctc cagatggcct cctgagctgg acgaccccag gtctccagac     1260

atctagggac cagagcaggt ttgggaacac agagggaaga caggatggga gtgtagccac     1320

agaacccacc tgcaccctga caggcacacc ccactgaaga gcctgagtcc caggaggcct     1380

cctggaagcc caggactgcc cacccaccac gctggtgccc accgcctggc cagccaagcc     1440

ctgccgatca gacatgtggg ctccccgaag cccagccaga gactgccgtg ctgtgggtgc     1500

caccaggccc agggactgca gcctgagctc cccgaggccc agggcagccg ggtgaggact     1560

ctgtcctgtg tcacctctct ccaggtgtcc agctgtctca tgcctttttg tcctgtcctc     1620

agctctccgt gtggtcagcg aaaccattgt tttctgttag gactcagttg caagaacaga     1680

aaccctgccc ccacttaata ataaaaaaga aagtttattg atgggtggtt gc             1732


<210> 3212
<211> 274
<212> DNA
<213> Homo sapiens

<400> 3212
tagaagttct acaagtccat gtggcacatc caagagtcca aacagagagt gggaaggaaa       60

atcagtcgcc tatatgcctt atgctgaggt caaacgtgct ctagaacagg aagcacagat      120

gcacaatact gcagcaaggt cagcctcacc gtgtaggctt tctccaagag aagtcagtaa      180

agccgctcca cagcctgata tgagtgcagc ccgctatagt gtcccgccag tccttcagcc      240

tgctccacat caagtgataa ctaatctccc tgaa                                  274


<210> 3213
<211> 3101
<212> DNA
<213> Homo sapiens

<400> 3213
gatgagacat gacaaagctg gctctgggaa gcatgcccta cctaggaccc tgccctgtgg       60

cccagggtgt cgtccggccc acttgcagtc ttaatctctg aattctgggc cctggaacag      120

gctgtgtcta gttctcattt gccgtactca ccgggcccct ttacatactc tactttctct      180

ttccctctgg gtttgagtgc tagtaacccc aggctcgtgt gtccactgct gtcatgctgc      240

tgtgggactt ccggcctctg agccagtctg gtcacctctc tgtgactccc ttagaggagg      300

ctctggatgc ttttacaggg ttaaatgata ccacaagagg cagggcagcg ggctcgacga      360

gctctgttct ggtgcgggca ggaggcggga gcccggatct gtgcgactga aggtgggaag      420

aggagtacac ggtgcggatc cagctgcaag accgtgtaaa tgagctccag gaggaagccc      480

aggaggctga tgcctgccag gaggagctgg cactgaaggt ggaacagttg aaggctgagc      540

tggtggtctt caaggggctc atgagtaaca acctgtcgga gctggacacc aagatccagg      600

agaaagccat gaaggtggat atggacatct gccgccgcat cgacatcacc gccaagctct      660

gcgatgtggc tcagcagcgc aactgcgagg acatgatcca gatgttccag aagaagctgg      720

tcccatccat gggggggcgg aagcgggagc gcaaggctgc cgtcgaggag gacacctccc      780

tgtcggagag tgaggggccc cgccagcccg atggggatga ggaggagagc acagccctca      840

gcatcaacga ggagatgcag cgcatgctca accagctgag ggagtatgat tttgaggacg      900

actgtgacag cctgacttgg gaggagactg aggagaccct gctgctttgg gaggatttct      960

caggctatgc catggcagct gcagaggccc agggagagca gcaggaagat agcctggaga     1020

aggtgattaa agatacggag tccctgttca aaacccggga gaaggagtat caggagacca     1080

ttgaccagat agagctggag ttggccacgg ccaagaacga catgaaccgg cacctgcacg     1140

agtacatgga gatgtgcagc atgaagcgcg gcctggacgt gcagatggag acctgccgcc     1200

ggctcatcac ccagtctgga gaccgaaagt ctcctgcttt cactgcggtc ccgcttagcg     1260

acccgccgcc gccgccaagc gaggctgagg actccgatcg cgatgtctca tctgacagct     1320

ccatgagata gagacctgcc tcccccttgc acccgaggcc ctcgcagcag ggagctcagc     1380

gaggcagagg gtggggctgc acagagggga acatcagctg cagctctgca ccaggccggt     1440

ccctggggac tggggcgctc ctccctcagg ctttctccct cagtcttggc ttctccaggg     1500

ctctggggtg tctggagcta ggcttggccc taccattctg gggccatttc caccacagtt     1560

ggggctctcc tgccttcacg cgtgggtgtc tgctacttcc ccatctttaa aatgctgcca     1620

gagcgattgc ggcccctcac cttgtccacg tatcaggaat gtgaatgtgg gacctttcct     1680

ccatccctgt tgtccggagc cagctcactg tcttccacac tggtgctaac tggcccaggc     1740

actggagtgg aatagaatgc agctggaggc tacgcatggc ctctgcagca cacgcagctg     1800

gagagggctt ctgtccctgt cagcggcaga gggcgttggg gctggccggg gcaccttgtc     1860

cctgctatgg tccacgtgct cacgctgtcc acctgccagg tggagtgtat gtggctgtgg     1920

ccctccctcg tggaggtgcc gtgctttaaa gaggccttag tgcccgggat gggcacagtg     1980

ttttgaaggg aggtgggagc tcttgctctc ctggtcactg cagaatgaca gagaaggtga     2040

agctccatgc atgtgtgcgc gggtgtatgt gcgctcaggg tctctgttta agtatcagct     2100

aaagatgtgc ttcctccgtg tctgtcatac actgagacca acaggctaca gtgtccctga     2160

ttcttggaaa agcctggaga agctggggag atgcggttca caatgcctcg gtataggagg     2220

ctgtgttgag ctgacattca aatggattct ttaataataa tgaaactggc gagtatttat     2280

tgtgcacttt ggtgtcactg tctcaagcac ttcctaatat tcactagttt gaactctgag     2340

gtaggtactt tttttttttt tgagatggag tctcatactc tgttgcctag gctggagtgc     2400

agtggtgtgg tctcagctca ctgcagcctc tgcctccggg gtgcaagcga ttctcctgct     2460

tcagcatgcc tgtagctggg actataggca tgtgccatga agcctggctg atttttgtaa     2520

ttttagtaga gacggagttt caccatgttg gccaggctgg tctcaaactc ctgacctcag     2580

gtgatacacc caccttggcc tcccaaagtg ctggggttac aggcgtgcgc gctctaccga     2640

ggtatgtact tttgtctcca ctaggtaagc acacgtgcaa agtgaggccc gggagtaact     2700

gcccaaagca actgagccgt tcagtggcag agccaggggt ctggacctag gtcccagcta     2760

cacgccttgc ccctacccaa gttcccctaa ggacgatgat ggaaataagt caccctgaca     2820

catctcagtt catcttcctc aaaactatgc gagatagcct aggactggag cgaggagagg     2880

aaaaggcctt gttctctgaa gtagtggtgc cagcttcctg tagcactcaa gacgtctgag     2940

cgggaagcaa atggttctcg aagcaagcaa ggctgtttgg aggccctacc ctcagtctga     3000

ggagaacata ccaggtccct ccccagcaag aatgtctcac cttgacacaa gcccagcttc     3060

cctcccctct gccccagacc ctagaataag acaggacaag t                         3101


<210> 3214
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 3214
gggagattac ggggcgggga cgagctgtcg cgctggttgc tcgtgcagga gcgggacccg       60

gaacagaccg ccgtgagaga ggaggggcgc cggccgggat tcgcggcccg gagctcggga      120

ccggttgctt cattccagcc tcgcagtcac ctctgtgccc tgctggttgt cttcccagcg      180

ctgctgtagt tgccttccat ggatctatag gagagcaagt cctccaggag aagaagtcct      240

caccagtgaa cggagacctc tctgaactaa gaataccatg gccacgtcag ccccactacg      300

gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac      360

cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg      420

gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt      480

gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca      540

gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa      600

gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg      660

ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa      720

aatcctgaac cacctgagta ccctaaggag agacagagac aaaattcagg gcttccaggc      780

aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat      840

tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga      900

acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg      960

cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca     1020

gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa     1080

gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga     1140

taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt     1200

ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct     1260

gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc     1320

ccagcagttt gactgtgagc ctggggtgct gggcagcaag ggcttcacct ggggcaaggt     1380

ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga     1440

ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga     1500

cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga     1560

ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag     1620

gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc     1680

cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag     1740

agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca     1800

ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct     1860

caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc     1920

caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc     1980

ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct ccccattgct     2040

gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt     2100

ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct     2160

ttcctttttg accacgacct tggccctagc tctgcactct ctggaataag ggcccgatgc     2220

agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc     2280

attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc     2340

ttccctggca ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa     2400

tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag     2460

cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc     2520

atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat     2580

ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga     2640

ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc     2700

aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc     2760

gggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact     2820

ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc     2880

ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa     2940

cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa     3000

ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa     3060

gttttaagtc ctccaccctg ttataagaga ctgttccaac ggctctgggc ctcagtggtc     3120

acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca     3180

catgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta     3240

tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat     3300

aaagacttgt tgaatgaa                                                   3318


<210> 3215
<211> 1054
<212> DNA
<213> Homo sapiens

<400> 3215
gacaacaaga tggcggcgct gcgggacggc tagcggccct gcgtggaggc gaggaatccg       60

catctatgga gatgtccctg catcccatga ctcggagctg atggccttca tgacgaggaa      120

gttgtgggac ctggagcagc aggtgaaggc ccagactgat gagatactgt ccaaggatca      180

gaagatagcg gccctagagg acctggtgca gaccctccgg ccacacccag ccgaggcaac      240

cctgcagcgg caggaggaac tggagacgat gtgtgtgcag ctgcagcggc aggtcaggga      300

gatggagcgg ttcctcagtg actatggcct gcagtgggtg ggcgagccca tggaccagga      360

ggactcagag agcaagacag tctcagagca tggcgagagg gactggatga cagccaagaa      420

gttctggaag ccaggggact cattggcgcc ccctgaggtg gactttgaca ggctgctggc      480

cagcctgcag gatcttagtg agctggtggt agagggtgac acccaagtga caccagtgcc      540

cggcggggca cggctgcgta ccctcgagcc catcccgctg aagctctacc ggaatggcat      600

catgatgttc gacgggccct tccagccctt ctacgatccc tccacacagc gctgcctccg      660

agacatattg gatggcttct ttccctcaga gctccagcga ctgtacccca atggggtccc      720

ctttaaggtg ataagctgct cctcaaacca cacctttggg gattttgaag ggagtgggga      780

tacacagcct ccccagacac ctcccattct gaggggaagc cgctgcactc cctgggggac      840

cccagtctga tgccctccag gaggataagt ctgaagccgg gctgggaagg gagcggagag      900

gcccgaaaca gagcagcagg cagcgccctc tgctggcacc ctggagacag cctcggctgc      960

ggggcccctg ccttctagtc ctccccagct ttcaggacac cttgacaacc tggggtccct     1020

gcagaagtgg cccggctgtc ccccaagtct cctg                                 1054


<210> 3216
<211> 3533
<212> DNA
<213> Homo sapiens

<400> 3216
gttgcctgat gacgagagtt gggagtgtgg ctggggctgc ggatctccag cagtggcgtt       60

acttctagcg gctggatacc gggttctccg cgagatcgcg agatcccgag atattctccc      120

cgcacggaag cgacgactgg cctggccaga ggactcgcgt gggagcgagg tgccggcccc      180

gacaggacgg tgagaaattg ttttacagcc tacccgtata ttacaagaaa tctcaagtca      240

aacactggaa aagatgtcag aagattcaga aaaggaagac tattcagaca gaacaatcag      300

tgatgaagat gaatcggatg aggatatgtt catgaaattt gtaagtgaag atcttcatcg      360

gtgtgcactt ttaacagctg actcttttgg tgatcccttc ttcccccgga ctacacagat      420

actattagaa tatcagctag ggagatgggt gccacgtctt cgtgaaccaa gggatttata      480

tggtgtctct tcttctggtc cattgagccc aacacggtgg ccataccatt gtgaagtcat      540

cgatgaaaaa gtccagcata ttgattggac tccttcttgt cctgagccag tgtatatccc      600

aacgggctta gaaacggaac ccctttatcc agactccaag gaagctactg tggtttatct      660

agctgaagat gcttacaaag agccctgttt tgtgtattcc cgagttgggg gtaaccgaac      720

acctttgaag cagcctgtgg attaccgtga caatactttg atgtttgaag caaggtttga      780

gagtggtaat ctacagaagg tagtcaaagt ggcagaatac gaataccaat tgactgtacg      840

ccctgacctc ttcacaaata aacacaccca gtggtactat ttccaagtca ctaatatgcg      900

agcaggaata gtctacagat tcactattgt caacttcacc aaacctgcta gtctttacag      960

tcggggtatg cgcccactgt tctattctga aaaagaggcc aaggctcatc acattggctg     1020

gcagagaata ggagaccaaa tcaagtatta taggaacaac ccaggccaag atgggcgcca     1080

ttatttctct cttacatgga catttcaatt tccacacaac aaagatacct gctactttgc     1140

tcattgctat ccatacactt acaccaacct gcaagaatac ctttctggca tcaataatga     1200

tccagtacgg tcaaagtttt gtaaaatacg tgttttgtgc cacacgcttg ctaggaacat     1260

ggtgtatatt ttaacaatca ctaccccctt gaagaactct gactcaagaa agcggaaggc     1320

tgtgattctg actgcaaggg tccatccagg ggaaaccaac agctcttgga tcatgaaagg     1380

cttcctagat tatattttag gaaactcaag tgatgcacag ttgcttcggg acacttttgt     1440

cttcaaggtg gtacccatgc tcaatccaga tggtgtgatt gtgggaaatt atcgctgttc     1500

cttagctgga cgggatttaa accgtaatta tacatctctc ctgaaggaat cttttccttc     1560

tgtatggtat acccggaaca tggttcatag actgatggag aaacgagagg ttattttata     1620

ctgtgatctt catggccata gtaggaaaga gaacatcttc atgtatggct gtgatggtag     1680

tgacagatct aagacattat acttacagca acgaatcttc ccacttatgc taagcaaaaa     1740

ttgtccagat aaattttcat tctcagcttg caagtttaat gtccagaaga gcaaagaagg     1800

aacaggaagg gtggtaatgt ggaaaatggg aatcaggaac agctttacca tggaggccac     1860

cttctgtgga tctactctgg gtaacaaacg aggcactcat ttcagcacga aagacctgga     1920

atcaatggga tatcattttt gtgattctct cttggattat tgtgatcccg accggaccaa     1980

gtattatcgg tgcctgaaag aattagaaga aatggaaaga catataaccc tggaaaaagt     2040

ctttgaggat tcagacacac ctgtgataga cattacattg gatgtagagt ctagtagccg     2100

aggctctgac agttcagaat ccattgactc tctgacttac cttctcaagt taacttctca     2160

gaaaaaacat ttgaaaacaa agaaggaaag gaattctacc atagcaagcc accaaaatgc     2220

cagaggacaa gaggtttatg atagagggca tttgctgcaa agacacacac aatcaaattc     2280

tgatgtgaaa gatacaaggc caaatgaacc agatgattat atggttgatt atttcagaag     2340

acaattacct aatcaaggtt tggatctgca ccacaactta aaaagcaaaa taaaagaatg     2400

catatctttc caaagcaaga agactggcat aaattggaca gatgatgaaa aaagaagcta     2460

caaggataaa ggaatagttc aaactcaaga aatattgcag tatttgctcc ccatcgtgca     2520

tagcactaaa aacatgcaaa ccactcagat aaaacagcta ttcaatccaa gaaccaactt     2580

ccaaatccaa catcaactaa atccggctac ttgcagaaat ataaagaaat acagcacatc     2640

ttggacagca cccagaaatc acccttttgt aatccaaggg gatgttatgg caaactcttc     2700

agaatgggtc cagtctaagc cccacaggtc attggaaagt ttatcacctc tcaaaggccc     2760

caagaagaat aaacattctc aaatctgggc cataaagaat gaagacataa aacctctcag     2820

cagcaagtgg gagactgctt cttcaagctt tggaatggat gcaaatgttc taaaatataa     2880

gagtcttcaa gctgaagaaa ctaaccagca aagctctaag catacagccc tccatctaac     2940

taaaaataag gatgagcagg ccaataagaa tgatggacaa cccaccttat atctgaagtt     3000

ccaaagggag agttaatcta gctttatact gctctgagaa ctgtgaatga aggataacat     3060

atgcttatgt agtaaaaaga aaaaaaggaa agccctcccc ttcccctttc cctatctctc     3120

cccttacaca tgcatatgca taaactaaaa attttagata tcccatcttc tgtagtggga     3180

acatctttca gagatttaaa aagaaatcca gagaaaatat ggaaaaatat taaagcagat     3240

atttatattt agtttttatc agcatggaaa aaaatctctg aagttttgat ttcttccaaa     3300

actacttaca cattcgacac caaaaaaact taagaactca aagtaggaat gacatataat     3360

atgtcactga ttttaacctc cctactagac actttaatca attagtcaac aaacatcatt     3420

tcctgatttt ctgttatatc attagtgtgc taggaaccat ttctctctac taggagatta     3480

ccacataatt gtacagataa aacatacctg aataaaatga ttacagaata aga            3533


<210> 3217
<211> 1487
<212> DNA
<213> Homo sapiens

<400> 3217
taacaacggc tacattcctc ccccagggcc aagggaaatc ctgagcgcag gccagggttg       60

tttggttttg aggtgtgctg ggatgaaagg caccctggaa gtggaaggtt cggtcattca      120

ttaattaatt acatctataa ttgagggttt gttcttaaga gcgagtcctt tgaaagtact      180

ttccttcaaa cagtgactgc cacaaaggca tcagatattc accaccttct cggctgcctc      240

agcacagcaa gctttattct gggacctgag atcctgttct gagctggctt tcccttctcc      300

aggctcgctc accctccctt tagagatagt ggatggtaag atgaccaatg ctcagattat      360

tcttctcatt gacaatgcca ggatggcagt ggatgacttc aacctcaagt atgaaaatga      420

acactccttt aagaaagact tggaaattga agtcgagggc ctccgaagga ccttagacaa      480

cctgaccatt gtcacaacag acctagaaca ggaggtggaa ggaatgagga aagagctcat      540

tctcatgaag aagcaccatg agcaggaaat ggagaagcat catgtgccaa gtgacttcaa      600

tgtcaatgtg aaggtggata caggtcccag ggaagatctg attaaggtcc tggaggatat      660

gagacaagaa tatgagctta taataaagaa gaagcatcga gacttggaca cttggtataa      720

agaacagtct gcagccatgt cccaggaggc agccagtcca gccactgtgc agagcagaca      780

aggtgacatc cacgaactga agcgcacatt ccaggccctg gagattgacc tgcagacaca      840

gtacagcacg aaatctgctt tggaaaacat gttatccgag acccagtctc ggtactcctg      900

caagctccag gacatgcaag agatcatctc ccactatgag gaggaactga cgcagctacg      960

ccatgaactg gagcggcaga acaatgaata ccaagtgctg ctgggcatca aaacccacct     1020

ggagaaggaa atcaccacgt accgacggct cctggaggga gagagtgaag ggacacggga     1080

agaatcaaag tcgagcatga aagtgtctgc aactccaaag atcaaggcca taacccagga     1140

gaccatcaac ggaagattag ttctttgtca agtgaatgaa atccaaaagc acgcatgaga     1200

ccaatgaaag tttccgcctg ttgtaaaatc tattttcccc caaggaaagt ccttgcacag     1260

acaccagtga gtgagttcta aaagataccc ttggaattat cagactcaga aacttttatt     1320

ttttttttct gtaacagtct caccagactt ctcataatgc tcttaatata ttgcactttt     1380

ctaatcaaag tgcgagttta tgagggtaaa gctctacttt cctactgcag ccttcagatt     1440

ctcatcattt tgcatctatt ttgtagccaa taaaactccg cactagc                   1487


<210> 3218
<211> 2345
<212> DNA
<213> Homo sapiens

<400> 3218
agtcaccggc ccctgctcaa gaatgccagt gtgtgtgtag cctccacaga gaggtcgttt       60

tctcggagtc cagaggggcc gcctgagctt ctgagaacta gggaggagcc atcccagcca      120

tgagcccctg ctccggaggg agaggtgagc tcagggcagc ctgcctgcag ccagaggtgc      180

cgggagcccc gggcctgtca tggtggccat ctacagccgg cctgaggcag tcacagacgg      240

atttgcagct gagcctgtct atctggtgtg ggaagaagat ggggagttac ttgtcagtcc      300

cggcttactt cacctccaga gacctgtttc ggtgttcaga atgccaggat tccctcacca      360

actggtacta tgagaaggat gggaagctct actgccccaa ggactactgg gggaagtttg      420

gggagttctg tcatgggtgc tccctgctga tgacagggcc ttttatggtg gctggggagt      480

tcaagtacca cccagagtgc tttgcctgta tgagctgcaa ggtgatcatt gaggatgggg      540

atgcatatgc actggtgcag catgccaccc tctactgtgg gaagtgccac aatgaggtgg      600

tgctggcacc catgtttgag agactctcca cagagtctgt tcaggagcag ctgccctact      660

ctgtcacgct catctccatg ccggccacca ctgaaggcag gcggggcttc tccgtgtccg      720

tggagagtgc ctgctccaac tacgccacca ctgtgcaagt gaaagaggtc aaccggatgc      780

acatcagtcc caacaatcga aacgccatcc accctgggga ccgcatcctg gagatcaatg      840

ggacccccgt ccgcacactt cgagtggagg aggtggagga tgcaattagc cagacgagcc      900

agacacttca gctgttgatt gaacatgacc ccgtctccca acgcctggac cagctgcggc      960

tggaggcccg gctcgctcct cacatgcaga atgccggaca cccccacgcc ctcagcaccc     1020

tggacaccaa ggagaatctg gaggggacac tgaggagacg ttccctaagg cgcagtaaca     1080

gtatctccaa gtcccctggc cccagctccc caaaggagcc cctgctgttc agccgtgaca     1140

tcagccgctc agaatccctt cgttgttcca gcagctattc acagcagatc ttccggccct     1200

gtgacctaat ccatggggag gtcctgggga agggcttctt tgggcaggct atcaaggtga     1260

cacacaaagc cacgggcaaa gtgatggtca tgaaagagtt aattcgatgt gatgaggaga     1320

cccagaaaac ttttctgact gaggtgaaag tgatgcgcag cctggaccac cccaatgtgc     1380

tcaagttcat tggtgtgctg tacaaggata agaagctgaa cctcctgaca gagtacattg     1440

aggggggcac actgaaggac tttctgcgca gtatggatcc gttcccctgg cagcagaagg     1500

tcaggtttgc caaaggaatc gcctccggaa tggcctattt gcactctatg tgcatcatcc     1560

accgggatct gaactcgcac aactgcctca tcaagttgga caagactgtg gtggtggcag     1620

actttgggct gtcacggctc atagtggaag agaggaaaag ggcccccatg gagaaggcca     1680

ccaccaagaa acgcaccttg cgcaagaacg accgcaagaa gcgctacacg gtggtgggaa     1740

acccctactg gatggcccct gagatgctga acggaaagag ctatgatgag acggtggata     1800

tcttctcctt tgggatcgtt ctctgtgaga tcattgggca ggtgtatgca gatcctgact     1860

gccttccccg aacactggac tttggcctca acgtgaagct tttctgggag aagtttgttc     1920

ccacagattg tcccccggcc ttcttcccgc tggccgccat ctgctgcaga ctggagcctg     1980

agagcagacc agcattctcg aaattggagg actcctttga ggccctctcc ctgtacctgg     2040

gggagctggg catcccgctg cctgcagagc tggaggagtt ggaccacact gtgagcatgc     2100

agtacggcct gacccgggac tcacctccct agccctggcc cagccccctg caggggggtg     2160

ttctacagcc agcattgccc ctctgtgccc cattcctgct gtgagcaggg ccgtccgggc     2220

ttcctgtgga ttggcggaat gtttagaagc agaacaagcc attcctatta cctccccagg     2280

aggcaagtgg gcgcagcacc agggaaatgt atctccacag gttctggggc ctagttactg     2340

tctgt                                                                 2345


<210> 3219
<211> 600
<212> DNA
<213> Homo sapiens

<400> 3219
gggacaccgg ggcgggggca ccgggaggaa gctgccttgg aagagtggac tgacgccgca       60

ggggcgagct agccggctcc gcgcctctcc gcgggatcca gacgcctcct ggggctgctg      120

gcggagggtc tgaggcggcg cggccatggc tcacctccgg ggatttgcca accagcactc      180

tcgagtggac cctgaggagc tcttcaccaa gctcgaccgc attggcaagg gctcgtttgg      240

ggaggtctac aagggcatcg ataaccacac aaaggaggtg gtggccatca agatcatcga      300

cctggaggag gccgaggatg agatcgagga catccagcag gagatcactg tcctcagtca      360

gtgcgacagc ccctacatca cccgctactt tggctcctac ctaaagagca ccaagctatg      420

gatcatcatg gagtacctgg gcggcggctc agcactggac ttgcttaaac caggtcccct      480

ggaggagaca tacattgcca cgatcctgcg ggagattctg aagggcctgg attatctgca      540

ctccgaacgc aagatccacc gagacatcaa agctgccaac gtgctactct cggagcaggg      600


<210> 3220
<211> 1953
<212> DNA
<213> Homo sapiens

<400> 3220
gattcccggg gttggtggca gcggcggtag cagcaatgga ctttctcctg gggaacccgt       60

tcagctctcc agtgggacag cgcatcgaga aagccacaga tggctccctg cagagcgagg      120

actgggccct caacatggag atctgcgaca tcatcaacga gacggaggaa gggtgctcga      180

cggcacctct cggccctcca ggtcttagaa acctgtgtca agaactgcgg gcaccgcttc      240

cacgtgctgg tggccagcca ggacttcgtg gagagtgtgc tggtgaggac catcctgccc      300

aagaacaacc cacccaccat cgtgcatgac aaagtgctca acctcatcca gtcctgggct      360

gacgcgttcc gcagctcgcc cgatctgaca ggtgtggtca ccatctatga ggacctgcgg      420

aggaaaggcc tggagttccc catgactgac ctggacatgc tgtcacccat ccacacaccc      480

cagaggaccg tgttcaactc agagacacaa tcaggacagg attctgtggg cactgactcc      540

agccagcaag aggactctgg ccagcatgct gcccctctgc ccgccccgcc catactctcc      600

ggtgacacgc ccatagcacc aaccccggaa cagattggga agctgcgcag tgagctggag      660

atggtgagtg ggaacgtgag ggtgatgtcg gagatgctga cggagctggt gcccacccag      720

gccgagcccg cagacctgga gctgctgcag gagctcaacc gcacgtgccg agccatgcag      780

cagcgggtcc tggagctcat ccctcagatc gccaatgagc agctgacaga ggagctgctc      840

atcgtcaatg acaatctcaa caatgtgttc ctgcgccatg aacggtttga acggttccga      900

acaggccaga ccaccaaggc cccaagtgag gccgagccgg cagctgacct gatcgacatg      960

ggccctgacc cagcagccac cggcaacctc tcatcccagc tggcaggaat gaacctgggc     1020

tccagcagtg tgagagctgg cctgcagtct ctggaggcct ctggtcgact ggaagatgag     1080

tttgacatgt ttgcgctgac acggggcagc tcactggctg accaacggaa agaggtaaaa     1140

tacgaagccc cccaagcaac agacggcctg gctggagccc tggacgcccg gcagcagagc     1200

actggcgcga tcccagtcac ccaggcctgc ctcatggagg acatcgagca gtggctgtcc     1260

actgacgtgg gtaatgatgc ggaagagcct aagggggtca ccagcgaaga atttgacaaa     1320

ttcctggaag aacgggccaa agccgcggac cgattgccca acctctccag cccctcagct     1380

gaggggcccc cgggtccccc atctggccca gcgccccgga agaagaccca ggagaaagat     1440

gatgacatgc tgtttgcctt atgagtgtgg ggtctggcac cctgcagccc aggtccccac     1500

tgctctcaca cccttaggct gggacctccc tccctcctct ggtgttaagg ctgctttggg     1560

ggtggcttgt tacccccttt tcctcctctt tgaagacgga gctgccccag ctgtggctgg     1620

gggtgtggag gcagtgggat gaactggggg acaggtctgc gctgcagtgg gatctggctg     1680

ctctgcctcc tttcccaccc cagctgacca tgagactttg ctgagaagtg gaggccccag     1740

gacaggctgg ctggctggct ggctgcttga cccagtgtga ctctccttca ctgagtgata     1800

ccctgctccg ggcccatgcc ccaaggagcc cttcagagcc cacactgcca gtcgaggcct     1860

ggctggaggc tggccacagt ggaaattctg ccgagcctct tgtcccttcc ctgctctgct     1920

gcatggggcc ccatggcttt ggctggccac tga                                  1953


<210> 3221
<211> 559
<212> DNA
<213> Homo sapiens

<400> 3221
cagaaccaga ctcatccagg attaggaagc tggggcccgg cgtggacggc aggctcgggg       60

ccaggatagc agcatcaagg agcattgtgt acatgcagaa gtgcacagta cctggagtga      120

aactgcttgt gttcgatttc tgataccatt cataactggc tgtgtgatct caaaacctct      180

aaaatgcaga cctccagctc tagatctgtg cacctgagtg aatggcagaa gaattacttc      240

gcaattacat ctggcatatg taccggaccg aaggcagatg cataccgtgc acagatatta      300

cgcattcagt atgcatgggc aaactctgag atttcccagg tctgtgctac caaactgttc      360

aaaaaatatg cagagaaata ttctgcaatt attgattctg acaatgttga atctgggttg      420

aataattatg cagaaaacat tttaactttg gcaggatctc aacaaacaga tagtgacaag      480

tggcagtctg gattgtcaat aaataatgtt ttcaaaatga gtagtgtaca gaagatgatg      540

caagctggca aaaaattca                                                   559


<210> 3222
<211> 470
<212> DNA
<213> Homo sapiens

<400> 3222
gggcggtgcc ggggcggcgg aggacggctt caggcccaaa ggggattggg cggcggctct       60

aggtggcggg tcttggtttg cggaaggggc tggagtcgct gcttctcggt gaccggcgcg      120

tggcccggcc aatcctgccg ccgccaccca cccgcaaccg cgtccgttga cggtcgggtc      180

cttggtcgcc gggtccttgc gggcaccaca gagcggggtg gcgtccgctc cctcgagtcc      240

tcggtgccag ggaattcacc gctcaccacc ccctgccccg ccttgggtcc tgctcgggga      300

ccaaaccact ggaaggcagt ggcgggaaac gggcgcctgt gccggagata atcctgatgt      360

aaaccattga catagccaga aaatcaccag gctgtgattt tccaaactca gcttcataac      420

ctattctgta gttgagggaa catgagccat ttgcagagct tattgttaga                 470


<210> 3223
<211> 561
<212> DNA
<213> Homo sapiens

<400> 3223
agaagtcgag ggtcatttgt tcaaaagttg gagaaatatc ctcttttgtt gcttcttcta       60

ctctgtagtg gagaatgggg aactggtagt tgtgtgggag ttatgtgtct ctaagatttg      120

tcgacccatt ttgatggcaa gggcataaaa tcttgttatt ttaatttgca tctgggagaa      180

tgtctgagca aggagacctg aatcaggcaa tagcagagga aggagggact gagcaggaga      240

cggccactcc agagaacggc attgttaaat cagaaagtct ggatgaagag gagaaactgg      300

aactgcagag gcggctggag gctcagaatc aagaaagaag aaaatccaag tcaggagcag      360

gaaaaggtaa actgactcgc agccttgctg tctgtgagga atcttctgcc agaccaggag      420

gtgaaagtct tcaggatcag actctctgaa aactgcaaat ggaaaggaat tcaaaagaat      480

ttagattaaa agttaaataa aaagtaggca cagtagtgct gaattttcct caaaggctct      540

cttttgataa ggctgaacca a                                                561


<210> 3224
<211> 4216
<212> DNA
<213> Homo sapiens

<400> 3224
gcaggggcgc cggcgggcgg atcgagagga aggtcggggc catgggccgg cactgcgcct       60

cgggagggtc cggccaccgc tggaacccga ggccggggct gggggcgctc cgggctccga      120

cccacgggcc ggccggccct gcccgggctg ggtgaggggc gcccgcctca agctagagga      180

ggagcggagg ccgcgcgcgg cccgccgagc gccttcagga tgctcatcaa ggaataccac      240

attctgctgc ccatgagcct ggacgagtac caggtggccc agctctacat gatccagaaa      300

aagagccggg aggagtctag tggtgagggc agcggcgtgg agatcctggc caaccggccc      360

tacacggatg ggcccggggg cagcgggcaa tacacacaca aggtgtacca cgtgggctcc      420

cacatcccag gctggttccg ggcactgctg cccaaggctg ccctgcaggt agaagaggaa      480

tcctggaatg cctaccccta cacccgaacc cggtacacct gccctttcgt ggagaaattc      540

tccattgaaa ttgagaccta ttacctgcct gatggggggc agcagccaaa cgtcttcaac      600

ctgagcgggg ccgagaggag acagcgcatc ctggacacca tcgacatcgt gcgggatgca      660

gtggccccag gcgagtacaa agcagaagag gacccccggc tttatcactc ggtcaagacg      720

ggccgagggc cactgtctga tgactgggca cggacggcgg cacagacggg gccccttatg      780

tgtgcctata agctgtgcaa ggttgagttc cgctactggg gcatgcaagc caagatcgag      840

cagttcatcc atgatgtagg tctgcgtcgg gtgatgctgc gggcccaccg ccaggcctgg      900

tgctggcagg atgagtggac agagctgagc atggctgaca tccgggcact ggaagaggag      960

actgctcgca tgctggccca gcgcatggcc aagtgcaaca caggcagtga ggggtccgag     1020

gcccagcccc ccgggaaacc gagcaccgag gcccggtctg cggccagcaa cactggcacc     1080

cccgatgggc ctgaggcccc cccaggccca gatgcctccc ccgatgccag ctttgggaag     1140

cagtggtcct catcctcccg ttcctcctac tcatcccaac atggaggggc tgtgtctccc     1200

cagagcttgt ctgagtggcg catgcagaac attgcccgag actctgagaa cagctccgag     1260

gaagagttct ttgatgccca cgaaggcttc tcggacagtg aggaggtctt ccccaaggag     1320

atgaccaagt ggaactccaa tgacttcatt gatgcctttg cctccccagt ggaggcagag     1380

ggaacgccag agcctggagc cgaggcagct aaaggcattg aggatggggc ccaagcaccc     1440

agggactcag agggcctgga tggagccggg gagctggggg ctgaggcatg cgcagtccac     1500

gccctcttcc ttatcctgca cagcggcaac atcctggact caggccctgg agacgccaac     1560

tccaagcagg cggatgtgca gacgctgagc tccgccttcg aggccgtcac ccgcatccac     1620

ttccctgagg ccttgggcca cgtggcgctg cgactggtgc cctgtccacc catctgcgcc     1680

gccgcctatg cccttgtctc caacctgagc ccttacagcc acgatgggga cagcctgtct     1740

cgctcccaag accacattcc actggctgcc ctgccactgc tggccacctc atcctcccgc     1800

taccagggcg ccgtggccac cgtcattgcc cgcaccaacc aggcctactc agccttcctg     1860

cgctcacctg agggtgccgg cttctgtggg caggtcgcac tgattggaga tggtgttggt     1920

ggcatcctgg gctttgatgc actctgccac agtgctaacg cgggcaccgg gagtcggggc     1980

agcagccgcc gtgggagcat gaacaatgag ctgctctctc cggagtttgg cccagtgcgg     2040

gaccccctgg cagatggtgt ggaaggcctg ggtcggggca gcccagaacc ctcggccttg     2100

cctccccagc gcatccccag cgacatggcc agtcctgagc ccgagggctc tcagaacagc     2160

cttcaggcag cccccgcaac cacctcctcc tgggagcccc ggcgggcaag cacggccttc     2220

tgcccacccg ctgccagttc cgaggcacct gacggcccca gcagcactgc ccgccttgac     2280

ttcaaggtct ctggcttctt cctcttcggc tccccactgg gcctggtgct ggctctgcgc     2340

aaaactgtga tgcccgccct ggaggcccag atgcgcccag cctgtgaaca gatctacaac     2400

ctcttccacg cggctgaccc ctgcgcctca cgcctcgagc ccctgctggc cccgaagttc     2460

caggccatcg ccccactgac cgtgccccgc taccagaagt tccccctggg agatggctca     2520

tccctgctgc tggccgacac tctgcagacg cactccagcc tctttctgga ggagctggag     2580

atgctggtgc cctcaacacc cacctctact agcggtgcct tctggaaggg cagtgagttg     2640

gccactgacc ccccggccca gccagccgcc cccagcacca ccagtgaggt ggttaagatc     2700

ctggagcgct ggtgggggac caagcggatc gactactcgc tgtactgccc cgaggcgctc     2760

accgcctttc ccaccgtcac gctgccccac ctcttccacg ccagctactg ggagtccgcc     2820

gacgtggtgg cgttcatcct gcgccaggtg atcgagaagg agcggccaca gctggcggaa     2880

tgcgaggagc cgtccatcta cagcccggcc ttccccaggg agaagtggca gcgaaaacgc     2940

acgcaggtca agatccggaa cgtcacttcc aaccaccggg cgagcgacac ggtggtgtgc     3000

gagggccgcc cccaggtgct aagcgggcgc ttcatgtacg ggcccctgga cgtcgtcacg     3060

ctcactggag agaaggtgga tgtctacatc atgacgcagc cgctgtcggg caagtggatc     3120

cactttggca ccgaagtcac caatagctcg ggccgcctca ccttcccagt tcccccagaa     3180

cgcgcgctgg gcattggtgt ctaccccgtg cgcatggtgg tcaggggcga ccacacctat     3240

gccgaatgct gcctgactgt ggtggcccgc ggcacggagg ctgtggtctt cagcatcgac     3300

ggctccttca ccgccagcgt ctccatcatg ggcagcgacc ccaaggtgcg agctggcgcc     3360

gtggacgtgg tcaggcactg gcaggactcc ggctacctga tcgtgtatgt cacaggccgg     3420

ccggatatgc agaagcaccg cgtggtggca tggctgtcgc agcacaactt cccccacggc     3480

gtcgtctcct tctgcgacgg cctcacccac gacccactac gccagaaggc aatgtttctg     3540

cagagcctgg tgcaggaggt agaactgaac atcgtggccg gttatgggtc tcccaaagat     3600

gtggctgtat acgcggcgct ggggctgtcc ccgagccaga cctacatcgt gggccgtgcc     3660

gtgcggaagc tacaggcgca gtgccagttc ctgtcagacg gctatgtggc ccacctgggc     3720

cagctggaag cgggctcgca ctcgcatgcc tcctcgggac ccccgagagc tgccttgggc     3780

aagagcagct atggtgtggc tgcccccgtg gacttcctgc gcaaacagag ccagctgctt     3840

cgctcgaggg gccccagcca ggcggagcgt gagggcccgg gaacaccacc caccaccctg     3900

gcacggggca aagcacggag catcagcctg aagctggaca gcgaggagtg aggcccacac     3960

cagcctggac ctgggttatt tattgacaca cccaaggggc ccgaggggct gcgtgtggga     4020

ggctggggac ccagactttt ggccccagcg ctggcccccc cagccccaca ccctatatct     4080

ccgtgtgctc ctcggtgtta cttccctttc atatgagggg acccagcgcc ggggggaggg     4140

aggagggcgt gggcatgggc gcagaggctt ttccagtgtg tataaatcca tgaaaataaa     4200

cgccacctgc acccca                                                     4216


<210> 3225
<211> 1969
<212> DNA
<213> Homo sapiens

<400> 3225
caagatggcg gccaaggtgg cgaagcagca gccgcggcgg cggcggcggc tggagtgagc       60

gtccgactcg ccgcgccgaa cgaggtcccg gtgtagggcc gcgcgccgtg gccgcgtccc      120

actcctcagg ccggggcgca cgtcggctcc cacgcttagc cagctcccga gtttcactct      180

tgttgcccag gctggagtgc aatggcacga tctcggctca ccgcaacctc tgcctcttgg      240

gttcaagcga ttctcctgcc tcagcctctc gagtagctgg gattacaggt ggtttcctag      300

aaacatgatt gtttattggc attgatctca cagtctggtg aggacttctt tactgataat      360

gtcaagttca ggttatcctc ccaaccaagg agcattcagc acagaacaaa gtcgttatcc      420

tcctcactct gtccagtata catttcccaa cacccgccac cagcaggagt tcgcagtccc      480

tgattatcgt tcctctcatc ttgaagtgag tcaggcatca cagcttttgc agcaacagca      540

gcagcaacag cttcgaaggc gaccttcctt gctttcagaa tttcacccag gttctgacag      600

gcctcaagaa aggagaacta gttatgaacc gtttcatcca ggcccatccc cagtggatca      660

tgattcactg gaatcgaagc gaccacgtct ggaacaggtt tctgattctc attttcagcg      720

tgtcagtgct gcggttttgc ctttagtgca cccgctgcca gaagggctga gggcttctgc      780

agatgctaag aaggatccag cattcggagg caaacatgaa gctccatcct ctccaatttc      840

ggggcaacca tgtggagatg atcaaaatgc ttcaccttca aaactctcaa aggaagagtt      900

aatacagagt atggatcgtg tagatcgaga aattgcaaaa gtagaacagc agatccttaa      960

actgaaaaag aaacaacaac agcttgaaga agaggcagct aaacctcctg agcctgagaa     1020

gcccgtgtcc cctcctcctg tggagcagaa acaccgcagt attgtccaaa ttatttatga     1080

tgagaatcgg aaaaaagcag aagaagctca taaaattttt gaaggtcttg gcccaaaagt     1140

tgaactgcca ctgtataacc agccatcaga taccaaggtg taccatgaga acatcaagac     1200

tggagtacct gcaaggcgca tgatgaaaaa ccaggtgatg aggaaaaaac tcattttatt     1260

ttttaaaaga agaaatcatg caagaaaaca aagggaacaa aaaatctgcc agcgttatga     1320

tcagctcatg gaggcatggg agaaaaaagt ggacagaata gaaaataatc ctcggaggaa     1380

agctaaagaa agcaaaacaa gggaatacta tgaaaagcag tttccagaaa ttcgaaaaca     1440

aagagaacag caagaaagat ttcagcgagt tgggcagagg ggagctggtc tttcagccac     1500

cattgctagg agtgagcatg agatttctga aattattgat gggctctctg agcaggagaa     1560

taatgagaaa caaatgcggc agctctctgt gattccacct atgatgtttg atgcagaaca     1620

aagacgagtc aagttcatta acatgaatgg gcttatggag gaccctatga aagtgtataa     1680

agataggcag tttatgaatg tttggactga ccatgaaaag gagatcttta aggacaagtt     1740

tatccagcat ccaaaaaact ttggactaat tgcatcatac ttggagagga agagtgttcc     1800

tgattgtgtt ttgtattact atttaaccaa gaaaaatgag aattataaag ccctcgtcag     1860

aaggaattat gggaaacgca gaggcagaaa ccagcaaatt gctcgaccct cgcaagaaga     1920

aaaagtagaa gaaaaagaag aggataaagc agaaaaaaca gaaaaaaaa                 1969


<210> 3226
<211> 2684
<212> DNA
<213> Homo sapiens

<400> 3226
gaggaggagg cgagccgcag cgccgcggcg acgaacccag ggagaaaagg aagcaaatga       60

gctgatggaa gatctgtttg aaactttcca agatgagatg ggattctcca acatggaaga      120

tgatggccca gaagaggagg agcgtgtggc tgagcctcaa gctaacttta acacccctca      180

agctctacgc cagcttctgt tactgatgta aggatgcaga gtcctgtcag gagttaggtg      240

tcaagtgaag tctccttgtt atggggcagt gcagctgtag gccaagctgt atctgtttgg      300

gaagggagaa aaaacagtag ctggcatcca tatccacttc tccgggtttg aggaactact      360

ggccaaccta ctaaatgaac aacatcagat agcgaaggaa ctatttgaac agctgaagat      420

gaagaaacct tcagccaaac agcagaagga ggtagagaag gttaaacccc agtgtaagga      480

agttcatcag accctgattc tggacccagc acaaaggaag agactccagc agcagatgca      540

gcagcatgtt cagctcttga cacaaatcca ccttcttgcc acctgcaacc ccaatctcaa      600

tccggaggcc agtagcacca ggatatgtct taaagagctg ggaacctttg ctcaaagctc      660

catcgccctt caccatcagt acaaccccaa gtttcagacc ctgttccaac cctgtaactt      720

gatgggagct atgcagctga ttgaagactt cagcacacat gtcagcattg actgcagccc      780

tcataaaact gtcaagaaga ctgccaatga atttccctgt ttgccaaagc aagtggcttg      840

gatcctggcc acaagcaagg ttttcatgta tccagagtta cttccagtgt gttccctgaa      900

ggcaaagaat ccccaggata agatcctctt caccaaggct gaggacaatt tgttagcttt      960

aggactgaag cattttgaag ggactgagtt tcttaaccct ctaatcagca agtaccttct     1020

aacctgcaag actgcccgcc aactgacagt gagaatcaag aacctcaaca tgaacagagc     1080

tcctgacaac atcattaaat tttataagaa gaccaaacag ctgccagtcc taggaaaatg     1140

ctgtgaagag atccagccac atcagtggaa gccacctata gagagagaag aacaccggct     1200

cccattctgg ttaaaggcca gtctgccatc catccaggaa gaactgcggc acatggctga     1260

tggtgctaga gaggtaggaa atatgactgg aaccactgag atcaactcag atcaaggcct     1320

agaaaaagac aactcagagt tggggagtga aactcggtac ccactgctat tgcctaaggg     1380

tgtagtcctg aaactgaagc cagttgccga ccgtttcccc aagaaggctt ggagacagaa     1440

gcgttcatca gtcctgaaac ccctccttat ccaacccagc ccctctctcc agcccagctt     1500

caaccctggg aaaacaccag cccaatcaac tcattcagaa gcccctccga gcaaaatggt     1560

gctccggatt cctcacccaa tacagccagc cactgtttta cagacagttc caggtgtccc     1620

tccactgggg gtcagtggag gtgagagttt tgagtctcct gcagcactgc ctgctatgcc     1680

ccctgaggcc aggacaagct tccctctgtc tgagtcccag actttgctct cttctgcccc     1740

tgtgcccaag gtaatgatgc cctcccctgc ctcttccatg tttcgaaagc catatgtgag     1800

acggagaccc tcaaaaagaa ggggagccag ggcctttcgc tgtatcaaac ctgcccctgt     1860

tatccaccct gcatctgtta tcttcactgt tcctgctacc actgtgaaga ttgtgagcct     1920

tggcggtggc tgtaacatga tccagcctgt caatgcggct gtggcccaga gtccccagac     1980

tattcccatc gccaccctct tggttaaccc tacttccttc ccctgtccat tgaaccagcc     2040

ccttgtggcc tcctctgtct cacccttaat tgtttctggc aattctgtga atcttcctat     2100

accatccacc cctgaagata aggcccacat gaatgtggac attgcttgtg ctgtggctga     2160

tggggaaaat gcctttcagg gcctagaacc caaattagag ccccaggaac tatctcctct     2220

ctctgctact gttttcccca aagtggaaca tagcccaggg cctccaccag tcgataaaca     2280

gtgccaagaa ggattgtcag agaacagtgc ctatcgctgg accgttgtga aaacagagga     2340

gggaaggcaa gctctggagc cgctccctca gggcatccag gagtctctaa acaactcttc     2400

ccctggggat ttagaggaag ttgtcaagat ggaacctgaa gatgctacag aggaaatcag     2460

tggatttctt tgagctagga gaataagagt ctggagactg ggagccttca cttcggcctc     2520

cgattggtgg cgcatagggt gtaaccaata ggaaacccct aaagggtact taaaccccag     2580

attttgcaac tggggctctt gagcagcttg ctttagcctg ctcccactct gtggaatata     2640

cttttgcttc aataaatctg tgcttttatt gcttcattgt ttca                      2684


<210> 3227
<211> 2872
<212> DNA
<213> Homo sapiens

<400> 3227
agcagcgcag gtgagcgccg cttccggggt cgggcgcctg gatagctgcc ggctccggct       60

tccacttggt cggttgcgcg ggagactatg gcgtcctcct cggtcccacc agccacggta      120

tcggcggcga cagcaggccc cggcccaggt ttcggcttcg cctccaagac caagaagaag      180

catttcgtgc agcagaaggt gaaggtgttc cgggcggccg acccgctggt gggtgtgttc      240

ctgtggggcg tagcccactc gatcaatgag ctcagccagg tgcctccccc ggtgatgctg      300

ctgccagatg actttaaggc cagctccaag atcaaggtca acaatcacct tttccacagg      360

gaaaatctgc ccagtcattt caagttcaag gagtattgtc cccaggtctt caggaacctc      420

cgtgatcgat ttggcattga tgaccaagat tacttggtgt cccttacccg aaaccccccc      480

agcgaaagtg aaggcagtga tggtcgcttc cttatctcct acgatcggac tctggtcatc      540

aaagaagtat ccagtgagga cattgctgac atgcatagca acctctccaa ctatcaccag      600

tacattgtga agtgccatgg caacacgctt ctgccccagt tcctggggat gtaccgagtc      660

agtgtggaca acgaagacag ctacatgctt gtgatgcgca atatgtttag ccaccgtctt      720

cctgtgcaca ggaagtatga cctcaagggt tccctagtgt cccgggaacc agcgataagg      780

aaaaggttaa agaattgccc acccttaagg atatggactt tctcaacaag aaccagaaag      840

tatatattgg tgaagaggag aagaaaatat ttctggagaa gctgaagaga gatgtggagt      900

ttctagtgca gctgaagatc atggactaca gccttctgct aggcatccac gacatcattc      960

ggggctctga accagaggag gaagcgcccg tgcgggagga tgagtcagag gtggatgggg     1020

actgcagcct gactggacct cctgctcttg tgggctccta tggcacctcc ccagagggta     1080

tcggaggcta catccattcc catcggcccc tgggcccagg agagtttgag tccttcattg     1140

atgtctatgc catccggagt gctgaaggag ccccccagaa ggaggtctac ttcatgggcc     1200

tcattgatat ccttacacag tatgatgcta agaagaaagc agctcatgca gccaaaactg     1260

tcaagcatgg ggctggggca gagatctcta ctgtccatcc ggagcagtat gctaagcgat     1320

tcctggattt tattaccaac atctttgcct aagagactgc ctggttctct ctgatgttca     1380

aggagctagg ggaagggggt tgtttgcctt cttcaggacc tgactggaca gatggacctg     1440

gctcaagcaa ctactctgga tgcactttgc tgtgtgggat gaactaaaag tgtctgaatt     1500

ttgctgataa ctttataaaa ctcactatgg catgcttccc tcctggtggg ccctaggatg     1560

gatgacactc aagatactac agatgtgggt gcaggcatgc acacacacga tggaatatgg     1620

ccattcctac acaggtgggg tagagagtgg gtcagcagcc tggcacctca cagaggtggg     1680

acctaagagg actcatgatt atgcagagaa ttggattggg tctctgtcat agattgagta     1740

atctcttccc ttacctcaat tccatctcca cccatctcta catctgggca cagcaaccca     1800

gagatggcca aaagcattca agcctggggg aagatgtttg actattgctg ctcttcacca     1860

gaacctcaca cctctcctgg gactggaacc cttcagtggg tgtgtggcca gttttggagg     1920

ctggaatgat gggccagggt gtaggattca ttctccatgt aaagtttcct ttcatcctgc     1980

ctagccatcc ccaaggttta tttccagaag aaaggaatat ctctacttgg atcaattctg     2040

gtcatttcaa gaggatggag gcctcaagtg tgggaacttc ccctactccc tggatgtgtg     2100

tacctagcac acttccttct cccacccctt tttccagttg gatttgtttt tctgttctct     2160

tctgtcctgt cttatactgc aactgtgtct cctaggggac agatggcctt ctttgtcatc     2220

ttcactctcc acccccagag aggagtcaga gccataactc aatcactcag cccctccaaa     2280

gatagttgat gtgtgataat ctcataatgt tgagaaccct gatgagatac attgtcttcc     2340

tctccctaca atgcctctgg ggccaaggca cccattcttc ttgctatcct ccatccccct     2400

tgaggcttcc actttttttt tttttagaca taaagctggg catcagcaac tggcctgtgg     2460

tgatgcaaag ctgctttgct ctgtatctgg ctggactgat ctgtctcaca agaagccatg     2520

aggccatagg gagaagctcc ctctcccctt catcttctgc tccaaaggtg gtagcaagag     2580

gagtacccag ttaggggttg gagcccccat ataacatctt cctgtcagaa gactgatgga     2640

tctttttcat tccaaccatc tccctttccc ccgatgaatg caataaaact ctgtgacacc     2700

agcaaccatt gctctttaga aatgggtttt ctgatcatat ggctgatgtg ttatgggcag     2760

tatggatgtc ttcatttgtt gcttctgttt ttcatctttt ttgttttatt aataaaaatt     2820

tatgtatttg ctcctgttac tataataata cagggaataa attattcaat cc             2872


<210> 3228
<211> 874
<212> DNA
<213> Homo sapiens

<400> 3228
ctcagcagcc gggccaagaa aggtctttgg gggcgcaagt ctttggaggg caggtctttg       60

gggagcgctt tgagtaatat tagagctttc actaaaccct ggcctattac gtcccctccc      120

ctgagattta cctttatata ctcaagttct ttcatgccag gaaggtaggc tgaaggcttc      180

gaaaacctgc agctcatacc caaagctagc actgtctatc cctggagacc cagcgcccaa      240

aagctccact gggcgcatag cgcacggcac gcctcctccc ccgagccgca gactgagtaa      300

ctggccccgg actaacctga ccagaagcaa gagataaagt aataatgggt actgtgggga      360

aaaacacaga agaacaattc ggtaatatag tggtgattta caagtcaagt taaaatgtcc      420

ccagaagtgg ccttgaaccg aatatctcca atgctctccc ctttcatatc tagcgtggtc      480

cggaatggaa aagtgggact ggatgctaca aactgtttga ggataactga cttaaaatct      540

ggctgcacat cattgactcc tgggcccaac tgtgaccgat ttaaactgca cataccatat      600

gctggagaga cattaaagtg ggatatcatt ttcaatgccc aatacccaga actgcctccc      660

gattttatct ttggagaaga tgctgaattc ctgccagacc cctcagcttt gcagaatctt      720

gcctcctgga atccttcaaa tcctgaatgt ctcttacttg tggtgaagga acttgtgcaa      780

caatatcacc aattccaatg tagccgcctc cgggagagct cccgcctcat gtttgaatac      840

cagacattac tggaggagcc acagtatgga gaga                                  874


<210> 3229
<211> 489
<212> DNA
<213> Homo sapiens

<400> 3229
ccccgctccc gacctggctt acgcggtccc gaccccgccc agctccgtgg cctcacctct       60

gactcctagg ccctccctgc ctaatcccct gccgcgggag cccgtctcga ccccttccat      120

gcctcccagt cccaccctgc ccagggcaag cccgctcggt gtgacggttc cccgcgagtc      180

gagggtggag aagccagcct ccttcccccg agtgggactc tagcagccca cctcttttag      240

gggtgctgag aacacccatt actcatccac agctactagg gtagctttct cagggtgcag      300

tgcttacggg gcggaggggg atggaaacag acccatgccc tggctggaag ggagctccag      360

tcgctagctc tcagggccag agcggggcag gaggatgctt tcccagcccc accatggagc      420

tgcgctgtgg gggattgctg ttcagttctc gctttgattc agggaatcta gcccacgtgg      480

agaaggtgg                                                              489


<210> 3230
<211> 2970
<212> DNA
<213> Homo sapiens

<400> 3230
aactacaaaa ttgaaagtag agaggagggg gcagccaatg gaaaaaaaaa tttgcacagc       60

agccaatcct cctgcggcgt tttgtgcctt tgcccaacag gaaaatgtgt ctcatgcaga      120

ggggcgttac ccagtctcca atgggcggga gccggtggaa cggaggagcc aatgagtgcg      180

agatgttgag tgacagctgt ccaatggagg ccctccgtgc tagtacggct tgcggcttaa      240

gcgccgccgc ggtctgcgga atgtcaacta ttcaacatgg aggcggaggt cgataagctg      300

gaactgatgg tgagtgcaaa gtgaaggaga tctactgggt agtttatttt tcccccatgg      360

cctcggaggt ggggcacaat ttggagtcgc cggaaactcc gggcggcgga ggctggacca      420

gagtcgagtt ccctcctcct gcaccaaagg gagccgccac cgtctggtgt ctaaaccgcc      480

tcggttccag aaagctgagt ctgatctgga ttacattcaa tacaggctgg aatatgaaat      540

caagactaat catcctgatt cagcaagtga gctgtcacca ctgactaaag aagagaaaac      600

tgcggcagag caattcaaat ttcacatgcc agatttatga agaaatggac ttggaaagga      660

aattctaaca gagaagagct taattccgga gaaatttagg aagatgtctt gttaaccctt      720

gatgtctaga gattgggggc tggtgaaggg ggtttggctt caatgactgg ataatgatat      780

ctttcatgag agagattata agaagaaggg cagataatat atgaataaag ttcagccaaa      840

aggatcaaat gagaataaaa cgatttaaat atatgtacac acgcatgcac acacacactt      900

agtcttgtaa tttcaggcca gaaattctca acactatttt gcatctgttt tctttttcta      960

agtcatgata atatagatgt tctggtctat cataaaagaa tgtttatgta catttcagtc     1020

attcggtatg tggctttgta aattaaagta taggcaaaac atttgtgtta tacatgatat     1080

ataatttcat tttgtaaatg ttgattgcac atgtggtcac attattgttg agactgcttt     1140

tatgtgacct gtagtctccc acagaaccta aagtaataag ctggcttttc tgtgatagcc     1200

acgtttgcgt atttctttcc ctatttccct tgcctgctaa tgttgaacag catgaacttg     1260

ctttctgatg ctgttttaga ctgtccctgt tgtatctcaa taatatcttt gttttccttc     1320

agcctttatt actataattg ttcattctac atgaaagcta ggaaactgaa attagaagag     1380

cacttatctg ctacttgcca gttttgcgtg agtgtgttat atgtatgtgt caatttccct     1440

ttaaaataac tatttatttt aaaataacta ttggcaataa ggaaactgtt caaagtagag     1500

gcagatcttg atagaaagat gttaatcaca gggttgttta taatagcaat atacatacac     1560

atttggctag tactaggtga ataggaaaat aaatcatgct gtatgtatac aataagaggt     1620

caagttgcca ataaattatt actgttaatg ttctgggaaa tgctgaaact atgctaagtg     1680

ggggagaggg aaagcaggta ttgcagtttt gtagtgaaga ttgggctttg gagtcatatc     1740

tgagatgtaa gtagcagctt ttaaattcta gctatgaccc tgtgcagatc acttaacttt     1800

tgagtgtcag gatgtttgga aggacaagac aggaaagtgt tttaatacag ggttcagtat     1860

ttagtaagcc ttcaataagt gatattacat acatgtaata aaaactaagc attgaaagga     1920

ctaggaaaaa tgcatcaaat gttagttctg caggttatag aattatactt ttatgtaatt     1980

ttaaaatttc agttatgaac atgtttgtcc attaacaaac ttataatagc tgaaaaacag     2040

ggttgtgaga acagcttcag ttaaaattgt cctgtctagt ttgaatattt caagaacaga     2100

aagccttttt tttttttttt ttttttttga gacggagtct cactctgttg cccaggctgg     2160

aatgcagtgg tacgctctca gctcactgca acctccacct cccaggttca agcagttctc     2220

tgccccaccc tcccgagtag ctgggattac aggcgcccgc caccacgccc ggctattttt     2280

ttgtattttt agtagagatg gggcttcacc atcttgacca ggctggtctt taactcctga     2340

tggtgatcca cccacctcgg cctcccaaag tgctgggatt acaggcatga gctaccgtgc     2400

ctggccccct tttttttaat tacagagaaa taagttacac cttagtatca gatattaatt     2460

ttcttcagtg ttcaggcaat tagtatttag aaagctcttg tcatgagatg gctctgggat     2520

gtgatgatga ttgttgggat tgaaaaaacg gtagtatcat ggagagatca taataaattc     2580

ttagtattaa aagtggtttt gctttcagtt agggagaaaa attagattgt actatttttc     2640

ctctatgatt tccttcagtt atcttccaaa tgttgttttt tccccacagc ccccttaaca     2700

ttgttctcta tgcacttctc aatacatttt catttgtttc tcaagcctct ttgtggatga     2760

ctcctaaata taacttcttc cactagctct agatccgtat ttccaataaa atcccctacc     2820

tgaatattca agttaaacat gtccagaata cttactgatt ttattgttaa tagccactat     2880

tctgttgtct ggaattaaaa cctgtataac taatttgcat ccctttatct tcttagtcaa     2940

taaaacctac aatcctcttt ctaaaatggt                                      2970


<210> 3231
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 3231
gagtcaggaa tggagagaag ggtaatggtt ttacctctta ttgtggaaac ctgttgagat       60

cacagagaat atactgacgg cataaaaggg cagaaccata gcagggtgcg cgctgctgta      120

gttgccttcc atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg      180

aacggagacc tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg      240

aagaggaggt gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact      300

gtggccacgt cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc      360

ccgtctgccc actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac      420

tggccagcct ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag      480

aggtgacccg ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact      540

actactgtga ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca      600

ggccccacac ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga      660

accacctgag taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag      720

aagctgatat cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg      780

agtttgagca gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg      840

cgaagctgga gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg      900

agcttgcccg gctggccctg gtcatctccg aactggaggg caaggcgcag cagccagctg      960

cagagctcat gcaggacacg agagacttcc taaacaggta tccacggaag aagttctggg     1020

ttgggaaacc cattgctcga gtggttaaaa aaaagaccgg agaattctca gataaactcc     1080

tctctctgca acgaggcctg agggaattcc aggggaagct gctgagagac ttggaatata     1140

agacagtgag cgtcaccctg gacccacagt cggccagtgg gtacctgcag ctgtcagagg     1200

actggaagtg cgtgacctac accagcctgt acaagagtgc ctacctgcac ccccagcagt     1260

ttgactgtga gcctggggtg ctaggcagca agggcttcac ctggggcaag gtctactggg     1320

aagtggaagt ggagagggag ggctggtctg aggatgaaga agagggggat gaggaggaag     1380

agggagaaga ggaggaggag gaagaggagg ccggctatgg ggatggatat gacgactggg     1440

aaacggacga agatgaggaa tcgttgggcg atgaagagga agaagaggag gaggaagagg     1500

aggaagttct ggaaagctgc atggtggggg tggctagaga ctctgtgaag aggaagggag     1560

acctctccct gcggccagag gatggcgtgt gggcgctgcg cctctcctcc tccggcatct     1620

gggccaacac cagccccgag gctgagcttt tcccagcact gcggccccgg agagtgggca     1680

tcgccctgga ttatgaaggg ggcaccgtga ctttcaccaa cgcagagtca caggaactca     1740

tctacacctt cactgccacc ttcacccggc gcctggtccc cttcctgtgg ctcaagtggc     1800

caggaacacg cctcctgcta agaccctgag ccctgacatc tgcccccagc cccaaccctc     1860

agatgcttca cttctttgga attccaggac tctcaatggg gggacgggat gcctggccta     1920

agcacctgga gcaggggacc ccatatccac tggtagccac ctccccattg ctgtggcccc     1980

ctgaaatctc actcagtgct gttgctccat ctactgccct aatggggctc ttttcccacc     2040

tcctgctggt ttcccgaggg aacttctgac cctggagtcc atgagggctc ctttcctttt     2100

tgaccacgac cttggcccca gctctgcact ctctggaata agggcccgat gcagcatttt     2160

cttgcccagt gtggcaagac ctcagaaaaa ccagtcaatt acgcctaaga tcattttgct     2220

gtccttaaac cccccaggtt ccttcttgca caaatccact ctgctgccca ccttccctgg     2280

cattttaaac agacctaccc caccccaact cagagttaag catacatggc aatgctgaaa     2340

ataaacaaaa tccactgagg cttcccaggc catttaaagc ctggagtacc agcgcatatc     2400

atctcatggg gtccagagtg gagtccaggc ttctctgaaa ccagggctga gcatatttcc     2460

atagccaagg aggtgggact ccctggagct atctgtggtc ttagggaagg atccagacat     2520

acacggcttt ggggtacaag ctgtgatcac tgatcaataa attatctcta gattggtcct     2580

tgtgagggga gttttaagaa tccagaacat cttgctcttg atcagcacat ccaaaaacac     2640

caagacaaac atccagtgga gcagaacctc tcctgcctcg ggagttctga ccgggttccc     2700

cagcagggtg ttaagcctct gtctctggcc ctaccagcat ccaggttcca ctttcctagg     2760

agagagtgga gatgggaaga cagggaaagg aaggcagcag gaggccacaa gcccaccagg     2820

tcttcatgtc aagagaggga gtaacatgtc ttctcattgc ccacggaccc aacctctgtc     2880

caggtgcccc tcatcatcac agtttaacac aagctcccct gctccagcca aattgatctc     2940

ccagtcttgt ccttacccat tccaagtgct ctgccagccc ctgttcatcc aagttttaag     3000

tcctccaccc tgttctaaga gactgttcca acggctctgg gcctcagtgg tcacttgacc     3060

accattgtct cagagctgcc cactttgtgt gtgtcacatg ctgcctgagt cacatgtaca     3120

tcttatttct gcctctagtt ttgtaagctc ctggagggcg gataacatct tatactactc     3180

ttgtattctc atggcaccta gtgcagtgct gggcacagag taggtgctca ataaagactt     3240

gttgaatgaa                                                            3250


<210> 3232
<211> 1306
<212> DNA
<213> Homo sapiens

<400> 3232
gagcgaagcg cacgctgagg aggatcggcg gccggtgagg gggaagcaag tctggtctct       60

gtgattgaag aagtcggctc tgggctccag tgcgggaatc acacacatac ctcagaatgc      120

cgggtctaag ttgtagattt tatcaacaca aatttcctga ggtggaagat gtagtgatgg      180

tgaatgtcag atccattgct gaaatggggg cttatgtcag cttgctggaa tacaacaaca      240

ttgaaggcat gattcttctt agtgaattat ccagaaggcg tatccgttct atcaacaaac      300

tcatccgaat tggcaggaat gagtgtgtgg ttgtcattag ggtggacaaa gaaaaaggat      360

atattgattt gtcaaaaaga agattaactt tgtgggaaac agagtccaat ttaaggaaca      420

cagagcagcg cttcctggct gtaaatccta gacttgaaag ttttccagta ttgaaaactt      480

caaagctgaa tattttttat ttctaagtat ttaaatgttc taacagatca gaacatgaaa      540

tgccctccta aatgtcagct gttgtcacac agtagctcca acactttgag catttttaag      600

ggagtggcct catttcacta gagacaaatc tttaagaata gttctaaaat tgggcttgtg      660

atttccattt ctgatgtctc cagattggca cccctttcta gttcaatgcc tcacgagatt      720

tgccaggggc atccaaggca aacaatccca atctttctat ataaaatgta ttcaagcaaa      780

catcaaataa atttctggga tatttaacta taggcttctt ccttcttgtc accagttaaa      840

agcattttaa tactaagacc ctaattcttt tatctttatt ttagtcttga tgtggaactg      900

taggagcagg tgaataaagg atctctataa cagatccttt caaaagaaga gttttagaga      960

aaataaattt aactttaacc acagtgaaag ttgaccctta gcgggacaaa gccttaaaat     1020

gcattgaaag aattagatcg gttctgtgcc ttttatctat ttgagattga tgacaacctg     1080

tgtgagagaa tttatcacac cacgtcctta ttggaataat aagctacttg ccttgagttt     1140

ataattcagg gtggtaaagt atgtttttaa attttaaaaa gcagctgcat tttttattta     1200

gttggaatat cacccaattt tttattttta ttgctattaa aatatccact agatgccacc     1260

tagagctcca gttctttata acaaaacagg gatctgtttg aacact                    1306


<210> 3233
<211> 4599
<212> DNA
<213> Homo sapiens

<400> 3233
actttgccag agcggccggg tccccattcc cattccttca aatccccttt ttcccggcag       60

ccgacctgta gacccaaggg agacaggttg aagctagaaa gagtcggggc agcagctctg      120

gtaggggagg gagcatccaa aacctctggc ttctgagcgc ctctcctgcc gcccatccac      180

aaagcccccc acagcctggc ggctgccctc gaccccgcaa aacaaaggac ttcagaggct      240

ggacctacag acccagatga gaaggcaaaa gcgtagggag gagcggcagg agatgggaag      300

ggcgggcccc gctcggagca gctgccgctt cctcccaaag tcccacgagg ggcctgagtc      360

acgggccacc gccctgggtc ggcgagctgg gggaagggat ctggacacct ggcgtgtccg      420

ggcgggaagc tggtgagggc ccctggggac agagcggagg accagtggtt ggggcgagaa      480

gagggcagtc ccgcagcgag tcccacgcgg ggtgggaggg atctaggccc cgccctctcc      540

tcggctccgc cctgcgcccc cttccctctc ctcattgtcc ttagacaaag cggtcgccgc      600

ccccgcccgg ccccctggtc tctgtctccg tccctcctcc tttgctgcct ctttccctcc      660

tcctctccct ccctcctccc ctccctccag tctccggatc tccctcggtc cctctctcct      720

cctcttcctc tctctggacg cccggctcct ccgcaccccc tcccccgggg gtcccgcggc      780

ctgtgagttg actgaggggc tcagacttgg ggagtgggtg tctcctcgcc cctgtccttg      840

ctcccgtccc tggcccggac cttggctgtc tcctctttgt gccgagattg tcagtctgtg      900

cggctacagc ggggtggaga cggccggctc tgtcacggct tcatgagagc ggggacgggg      960

cgcaggactt gcaggcgccg gggagaagag acatggagcc ggcccttggc actctggggt     1020

cgcgtggggc agtcggtggg ggaggcaggc ggtggtgaca ggacagggtg ggggtggacg     1080

ccagggttct gggaacgcgc tggcagccct gacgcccggg ttccgaaagt ctcgggggtg     1140

gctatttccc ccgacccgcc tcgggggcgg agtgcggggc agaggggtgg gggctgggga     1200

gaggcgtggc ccgagcggtg ctggaagcgg agccgggacc tttggggccc gcgctgagac     1260

gcgcccggct gctgccgccg ccctcctttc ccctcttccc tggtttccct tctcctctag     1320

acctgttcgc tctccgcccc tccttgcctc cccaacaccc cctcaggtcc cgttgcctcc     1380

tggtcctttc agggattcct ggtccttcct tcccacacta gcctccctgg ggtatcgctg     1440

aggcagcctg gcctgcaccc aggttcccct cacccctgcc acatttctct cttctccctc     1500

acgccaactt tccttttcgc ccttctctct ctttctcaca tcctagagac ggtctttaat     1560

acgcattaac cctgtgctgc cacatctggc tcctgccctc attgcctcca atccggactc     1620

ttcctctcac atcaccccca ccacccccaa cttgggctca caacttctct tcactttttc     1680

catttcccca gttctctgcc ttccgtcttt ccctctgtcc tcatccttag cccctctgcc     1740

ctgctttgtg tcccacctct ccccctccac ttcctctcct cccaccctca gtctcacccc     1800

cgggctgtct cactctctgg agcctctcct tcctgttctc tgtccccagt gctccctacc     1860

ctcacctcaa gacgaccatg gccaccatcc cagactggaa gctacagctg ctagcccggc     1920

gccggcagga ggaggcgtcc gttcgaggcc gagagaaagc agaacgggag cgcctgtccc     1980

agatgccagc ctggaaacga gggctcctgg agcgccgccg ggccaagctt gggctgtccc     2040

ctggggagcc tagccctgtg ctagggactg tagaggctgg acctccagac ccggatgagt     2100

ctgcggtcct tctggaggcc atcgggccag tgcaccagaa ccgattcatc cggcaggagc     2160

ggcagcagca gcagcagcaa caacaacgga gtgaagagct gctagcagag agaaagcctg     2220

ggcctctgga ggcccgggag cggagaccca gccctgggga gatgcgggat cagagcccca     2280

agggaagaga gtcaagagaa gagagactaa gtccgaggga gaccagagag aggaggctgg     2340

ggataggggg agcccaagag ttgagcctga ggcctctgga ggctcgggac tggaggcaaa     2400

gcccaggaga ggtgggagac aggagctccc gactgtcaga ggcatggaaa tggaggctga     2460

gtcctggaga aactccagag cggagtctga gactagcaga gtctcgagag caaagcccca     2520

ggagaaaaga ggtggaaagt agactgagcc caggggaatc tgcctaccag aagttgggcc     2580

tgacagaggc ccataaatgg agacctgact ccagagagtc tcaggaacag agtttggtac     2640

aactggaggc aacagagtgg aggctgaggt caggagaaga aagacaagac tactcggaag     2700

aatgtgggag aaaagaagag tggccagttc caggggtagc tccaaaagag actgcagagc     2760

tgtccgagac cctgacaagg gaggcccaag gcaacagttc cgcaggagtg gaggcagcag     2820

agcagaggcc tgtggaagat ggcgagaggg gcatgaagcc aacagaaggg tggaaatgga     2880

ccctgaactc cgggaaggct cgagaatgga cacccaggga catagaggct caaactcaga     2940

aaccagaacc tccagagtca gcagagaagc ttctggaatc tcccggtgtg gaggctggag     3000

aaggggaggc tgagaaggag gaggcggggg ctcagggcag gcctctgaga gccctgcaga     3060

actgctgctc tgtgccctcc cccctcccac cagaggacgc tgggactgga ggcctgagac     3120

agcaggaaga ggaagcagtg gagctccagc ccccaccacc agcccctctg tctcccccac     3180

ccccagcccc aactgccccc caacctcctg gggatcccct catgagccgc ctgttctatg     3240

gggtgaaggc agggccaggg gtgggggccc cccgccgcag tggacacacc ttcaccgtca     3300

acccccggcg gtctgtgccc cctgcgaccc cagccacccc aacctctcca gccacagttg     3360

atgctgcagt cccgggggct gggaagaagc ggtacccaac tgccgaggag atcttggttc     3420

tggggggcta cctccgtctc agccgcagct gccttgccaa ggggtccccc gaaagacacc     3480

acaaacagct taagatctcc ttcagcgaga cagccctgga gaccacgtac caatacccct     3540

ccgagagttc ggtactggag gagctgggcc cggagcctga ggtccccagt gcccccaacc     3600

ctccagcagc ccaacccgac gacgaagagg atgaggaaga gctgctgctg ctgcagccag     3660

agctccaggg cgggctgcgc accaaggccc tgattgtgga tgagtcctgc cggcggtgac     3720

catcttccaa catagggata tacctccctc cttcttataa ctgaagatcc tggagcccgg     3780

aagattcagg gcagacagac cctgataatg agcctggcag ggaagggcaa ccaacatctt     3840

gtaacttgct ttccccaccc tgtttctggg ggcagagcca attgcccaat ttctacccta     3900

atccaaagtc cctggtgtgg gtggggttaa acgtgctggt gcatcctagg tcatccaaga     3960

gtgagcgcca agtcctgaga aggggcacag aactccctgg agggtggaga tggagcacct     4020

gccccccatg gcagggtaca ctctccccac agccttcctc cccaccatcc cgtggggact     4080

ctcgggattt aagcactcgt ctctctggga ggcccagacc ccactccatt tataggcaca     4140

tctccttcat ttcctaggtc actgcccctt tgtttacagc tcctgcctcc tcccttgacc     4200

acagcctggt ttacaaattc catcagctcc cagccccacc tgccaaagtc ccaggtttac     4260

aagccacgct tacttgctgt gtctgcgtgg aattctctcc tctgtcccct ccagtctcct     4320

cattggagtg acctgaaggt gtggcttcct ccactttttc tcagtattac tttgccttag     4380

ttttccccaa gagggaaggc tggaactctt aactctgtac cccttgatag ttatttaatt     4440

ctgtttctcc tagtggttca caattgaact gaattgagat ggtgtcgggt ggctaaggag     4500

acacctcacc tctccttccc cattgtgccg cctttatcaa ttgcctgttt tgttttgttt     4560

gttttttaac tttccataat aaaatggagt tctcttcaa                            4599


<210> 3234
<211> 3484
<212> DNA
<213> Homo sapiens

<400> 3234
attgcaaagc cacagggaac ataccaggtg ttacctccaa acacaggctc tctttatatt       60

gacaaggatt gttcagctgt gtactgccat gagtcaagca gtaatatata ctatcctttt      120

caaaagcgtg agcagctgcg agctggcagg tacatcatga ggcatacttc agaggttatc      180

tgtgaggttc tggatcctga gggaaacact tttcaggtca tggctgatgg tagcatatca      240

actatattac ctgaaaaaaa attggaagat gatttaaatg agaaaactga gggctatgat      300

agtctgtcct ctatgcacct tgaaaagaat catcagcaaa tctatggtga acatgtcccc      360

aggttttttg ttatgtatgc tgatggatca ggaatggaac ttcttcgaga cagtgacata      420

gaagaatatc tatctttggc atataaagaa tcaaatactg ttgttctcca agagccagtg      480

caggaacagc caggcaccct aaccatcaca gtccttcgcc ctttccatga agcatcacca      540

tggcaagtaa aaaaggaaga tacaattgtc cctcctaatc tccggtcaag gtcatgggaa      600

acatttccct cagttgagaa aaaaactcca ggacctccgt ttggtactca gatttggaaa      660

ggcctttgca ttgagtccaa acagctagtg agtgccccgg gtgccatact caagagcccc      720

agtgtgctac agatgcgcca attcattcag catgaggtca taaagaatga ggtgaaactg      780

aggctgcagg tttcccttaa ggattacata aactatattc taaagaaaga agatgagctg      840

caggaaatga tggttaaaga ttccagaact gaggaggaga gaggcaatgc tgctgatctc      900

ctcaagctgg ttatgtcttt ccctaaaatg gaggaaacta caaaaagtca tgttactgaa      960

gttgcagctc acctaactga tttattcaag cagtctttgg ctacgcctcc aaaatgccca     1020

ccagacacat ttggtaaaga tttctttgaa aagacatgga gacacacagc atcctcaaaa     1080

cgctggaaag aaaagataga caaaacgagg aaggaaattg agacaacaca gaattaccta     1140

atggatatta agaaccgcat aataccaccc ttttttaaat ctgaattgaa ccagttatat     1200

cagtctcagt ataatcacct ggacagtctt tccaaaaaac tgccttcttt tacaaagaaa     1260

aatgaagatg caaacgaaac agctgttcaa gatacatctg atcttaatct agatttcaag     1320

ccacataagg tttcagaaca gaaatcctca agtgtgccta gtcttccaaa accagagatt     1380

tctgcagata agaaggattt cactgctcag aaccaaactg aaaatttaac aaaatctcct     1440

gaagaagcag aatcttatga gcccgtgaaa attccaaccc agtccttgct gcaggatgtt     1500

gcgggacaaa caagaaaaga aaaagtgaag ttgcctcatt atttgctgag ttccaagcct     1560

aagtctcaac ctcttgcaaa ggtgcaagat tctgttggag gaaaagtgaa cacatcctct     1620

gttgcatctg ctgccattaa taatgcaaag tcatcccttt ttgggttcca tcttctccca     1680

tcatcagtca agtttggagt gcttaaggaa ggacatacct atgccacagt tgtaaagctc     1740

aagaatgttg gagtggactt ctgcaggttt aaagtaaagc agcccccacc cagcacagga     1800

ctgaaagtga cttacaaacc tggacctgtg gcagctggta tgcagacaga actgaatata     1860

gagttatttg ccacagctgt tggagaggat ggggccaagg gatcagcaca catctctcac     1920

aatatcgaga ttatgacaga gcatgaggtt ctgttcctac ctgtggaagc aaatatcctt     1980

taaagttcaa cttgagtaat catatatagt gcagaaatta cacgagtgag gaaaacatgg     2040

aagtcaaaat gcatctctac tttattaatt ctatcttcaa aatcagagtt aaatttatta     2100

agacaaagag catcttcatt catctttgaa agcacctagc caaatctaaa aaaatacctg     2160

acacatagta tatgtgcagt aacttcagat tgaataaatg taaatgttat tggctatcta     2220

cggaatatca gacagaataa taaaacagca agtatctatc acaaaaaaat tataatttta     2280

tggaaggata ggaaatacct tattattata aaggttgggt attcactgaa ttatgcatgc     2340

attcctcctt atcagtgtct tcagccaaac agatattaga tagatatcaa gaacctatta     2400

cctccaaggt actgtataaa atagtttatc atatataaaa atggataatt ggactctgtc     2460

ttaaaaggta ttatataatt tgtagcagaa ataaagtctt cacattttat ttctattttg     2520

tactttctcc agtggcatga attgtgtgct gcttgtgtta cagttctcta tttatttgat     2580

ttttgagctg gatcttatag aatgtgaaaa cttgattgac gggaacttta agtaaaaata     2640

atgaacaaaa ccatggcaac aggaaagctc caggtgtttg ggatgattgg cagggagttc     2700

aacttgccaa aagcttgagt attaggaata tagtgggaaa gtaggttgga gtcaagttat     2760

gaaagatctt aaatccttgg cttgaatttt attatttaag cagcagtgaa ccactgcaga     2820

ttcctgaccc tgtgggtgac atgatcagca tatctttatt aagatgaatc cagggttatt     2880

gtgcaggaca tgtcaaaggg gaacaactgg atgtgtaaaa gtaccattag aagtctacct     2940

gaatgggcca tgtgtgagga caagaactgg gagtggggga acagtcaaca taaaagaggg     3000

acatgaatga aagacatggt gggggaagga aactgcaaaa tctgaggtag aagccattga     3060

tggatggaag aaagaggaca tcgagttcaa cttcaaagtt ttgggctgag gtaatgaatc     3120

atgtatatgt aatattagat ctcaactgag aagtcagaat tggagatata ataattttaa     3180

gcatcgttta cacagaggtg atggctgaat gtatgggcaa ggaacagaaa tctggagtcg     3240

gtttagggag caggaggaag aagagccagt ggagacaaaa gcagcaatta gaaaatggtg     3300

aaatacttca aaagccttag gaagaatttc aaggaaaaga cggacacaat tgacggatgc     3360

tattgagatg tcaaagaaaa ttcagattta aagtgttaaa tttggttggg ataaaaacta     3420

aattgcaaaa ggtaaagaat gactgtatta agaaagcaga aacattagtt atggatattc     3480

tttc                                                                  3484


<210> 3235
<211> 3381
<212> DNA
<213> Homo sapiens

<400> 3235
agctttcaaa aatagcatag ttgatgaaac tggaaattta ggtgcgggct cttttaagaa       60

atcatttgtc ttcagtctta agaatagact gacaacagat actgctacca gagggctctc      120

aactatttct taagaccccc taggaaatat cagaagaaaa gcctccttct caataaagca      180

taagtaggac atctcgtttt cagtgaatca gacacttgga ttggacttaa tcttaaacct      240

ctggagttca agacctttta aaaagggcta aataaacaat ctctacatgt aaaaggccac      300

tgactcctac ttcctctgta tagagcaact gttgaactca gctgcctgta gggcgtgatt      360

ctcagtcacc agactcagca aaaggtttta gaagcgttcg accaaaccta caagataaaa      420

gatcaccaac tcaggcaccc cctccaccag aaagaaaaga gagctttcat agctctttga      480

taaccagtca cacaaagggt gtcattttag accagttagt aactaacaca caaattccct      540

ccagtacaga gtactttgct aacaaaaaac ctcttcaggg aactatgtat tccaatgaag      600

attcgagaca gacaattgta tattctgaag aatctaacac aaccatgtca tatacacaaa      660

aaatcactaa tccactacca gcagcttcca gcacggatcc tgcaccattc gctaacatca      720

acaccccagt tctacaagag gactacaggc aagattctca aactcggagg atttctacct      780

tgaaactaac ccataaccag gatctaggaa gtagcagccc cattagtact ccacagttct      840

ccaaatctgt cgaagtaccg tcatttctca aaaggccccg ctcactgacc cctaatccag      900

tgcctgagac acacacagca tctctttcca ttcagatagc tcccctttca ggacaggatc      960

ttgaaagcca caaacagcta cctgagcttt ctccagagac tgcaaagata cctcttcagc     1020

aagagagaca aaaatctgca gttgcagcgg cctctcagtc ctcagactgc agagtgagcc     1080

agataacagt gaatggaaac tcaggaggtg ccgtgagtcc catgagttac tatcagaggc     1140

cgttttcccc ctcggcatat tctctcccag cctcactcaa ctccagcatt gtcatgcagc     1200

acggcacatc cctcgattcc acagacacat atccccagca tgcgcagtct ctggatggca     1260

ccaccagcag ctctatcccc ctgtaccgat cctcagagga agagaagaga gtgacagtca     1320

tcaaagcccc gcattaccca gggatcgggc ccgtggatga atccggaatc cccacagcaa     1380

ttagaacgac agtcgaccgg cccaaggact ggtacaagac gatgtttaag caaattcaca     1440

tggtgcacaa gccggatgat gacacagaca tgtataatac tccttataca tacaatgcag     1500

gtctgtacaa cccaccctac agtgctcagt cacaccctgc tgcaaagacc caaacctaca     1560

gacctctttc caaaagccac tccgacaaca gccccaatgc ctttaaggat gcgtcctccc     1620

cagtgcctcc cccacatgtt ccacctccag tcccgccgct tcgaccaaga gatcggtctt     1680

caacagaaaa gcatgactgg gatcctccag acagaaaagt ggacacaaga aaatttcggt     1740

ctgagccaag gagtattttt gaatatgaac ctggcaagtc atcaattctt cagcatgaaa     1800

gaccaccccc tctcccaaca actccgacac ctgttccaag ggaacctggc cggaagcctc     1860

tttctagctc ccgactcgga gaagtcactg gtagcccctc ccctccgccc cggagtggcg     1920

cccccacacc aagctcgcgc gccccggctc tgtctcccac ccggcctcct aaaaagcctc     1980

tggactatgt tcaagatcat tcttctggtg ttttcaatga ggcctccttg tatcagtcct     2040

ctatagacag aagcctggaa agacccatga gttctgcaag catggccagt gacttcagga     2100

agcggaggaa gagcgagcct gcagtgggtc caccacgggg cttgggagat caaagtgcga     2160

gcaggactag cccaggccga gtggacctcc caggatcaag caccactctt acaaagtctt     2220

tcactagctc ttctccttct tccccatcaa gagcaaaaga ccgtgagtcc cctagaagtt     2280

actcatccac tttgactgac atggggagaa gtgcaccaag ggaaagaaga ggaactccag     2340

aaaaagagaa attgcctgca aaagctgttt atgattttaa ggctcagaca tctaaggagt     2400

tgtcatttaa gaaaggagat actgtctaca tcctcaggaa aattgatcaa aattggtatg     2460

agggagaaca ccacgggaga gtgggcatct tcccgatctc atacgtagag aaactcacac     2520

ctcctgagaa agcacagcct gcaagaccac ctccgccagc ccagcccgga gaaatcggag     2580

aagctatagc caaatacaac ttcaacgcag acacaaatgt ggagctgtca ctgagaaagg     2640

gagatagagt tattcttctt aaaagagttg atcaaaactg gtatgaaggt aaaatcccag     2700

gaaccaacag acaaggcatc ttccctgttt cctatgtgga ggtcgtcaag aagaacacaa     2760

aaggtgctga ggactaccct gaccctccaa taccccacag ctattctagt gataggattc     2820

acagcttgag ctcaaataag ccacagcgtc ctgtgtttac tcatgaaaat attcaaggtg     2880

ggggggaacc gtttcaggct ctgtataact atactcccag gaatgaagat gagctggagc     2940

tcagagaaag tgatgtcatt gatgtcatgg aaaagtgtga tgacggctgg tttgtgggga     3000

cctcaagaag aaccaaattc tttggtactt tccccggaaa ctacgtcaag aggctgtgaa     3060

ttgcgctccc tccttctgta gaggccgcct gccagccatg cacctgcgtc aacgcgcctg     3120

aaacaccccg cgggcctccc gttgtcatgc cttacggttt ccaatgcgcc gtcaccatct     3180

ccacctgcca ccaaaccacc agcagagtag ccgccgctgc tgtgagcctg gggacgacat     3240

ggcaggctgg tccccctccg tgaaagtgtg gattcctact tcctgctcta agctttgaca     3300

cgtcaaaatg tgggatcaga aagaaaaaaa tcatgatatt taaaaatggt caaatatttg     3360

aggcaaaaaa aaaaaaaaaa a                                               3381


<210> 3236
<211> 225
<212> DNA
<213> Homo sapiens

<400> 3236
atgagatact atggcagcta ctacagaggc ctgggatatg gctgtggagg ctttggtggt       60

ctgggctatg gctgtggctg tggaggctac agatatggct ctggctatgg aggctataga      120

tatggctgct gccgcccatc atgccgtgaa ggatatggat tctctggatt caaaaaactt      180

gctgattctc atactctaac tccaagatct tgcccgtatg cttca                      225


<210> 3237
<211> 563
<212> DNA
<213> Homo sapiens

<400> 3237
ctttgttgtg agctgcggca gagactggtg gctggaggag acgccggcgc tggagagtgc       60

gctgcgccgc ccgccgctga gggaccgcgg ggttagccac tgctggctgc ttccagtgtt      120

cgccgagagg taccgggggt gacagctccg ggaccggccg aaaggcgagg aaccggtgtg      180

gaaattaaaa gaacacacat attttgactg gggctttgat caaccaaatg ctaaaaaggc      240

tggagtgcaa tggtgcgatc tcggctcact gcaacctccg cctcccgggt tcaagtgatt      300

ctcctgtctc ctgggttcaa ccacataaag aagatcccta atagtcattt ctcaacaatt      360

atatagtcaa ctgatgtaac aatggtacta atattgggac gcagactaaa cagagaggat      420

cttggggtgc gtgattcccc agcaactaag cgaaaagttt ttgaaatgga ccccaaatct      480

ctgacaggtc atgagttttt tgacttctct tcaggatcat cccatgccga aaacatactc      540

cagatattta atgaatttcg tga                                              563


<210> 3238
<211> 1083
<212> DNA
<213> Homo sapiens

<400> 3238
acttcctgcc gggctgcggg cgcctgagcg gctcttcagc gtttgcgccg gcggctgccg       60

cgtctctctc ggctcccgct tcctttgacc gcctcccccc cccggcccgg cggcgcccgc      120

ctcctccacg gccactccgc ctcttccctc ccttcgtccc ttcttcctct cccttttttc      180

cttcttcctt cccctcctcg ccgccaccgc ccaggaccgc cggccggggg acgagctcgg      240

agcagcagcc agacggagtc tcgctctttt gccaggctgg agtgcagtgg cgcgatcctg      300

agtcactgca acctccacct cccaggttca agcgattctc ctgcttcagc ctgccaagta      360

gctgggacta cagagtttat taaccactta acctctcaga actgaacaaa gacaacattg      420

ttcctggaac gccctctttt taaaaaagaa agcataaccc ctactgtaga actaaatgca      480

ctgtgcatga aacttggaaa aaaaccaatg tataagcctg ttgaccctta ctctcggatg      540

cagtccacct ataactacaa catgagagga ggtgcttatc ccccgaggta cttttaccca      600

tttccagttc cacctttact ttatcaagtg gaactttctg tgggaggaca gcaatttaat      660

ggcaaaggaa agacaagaca ggctgcgaaa cacgatgctg ctgccaaagc gttgaggatc      720

ctgcagaatg agcccctgcc agagaggctg gaggtgaatg gaagagaatc cgaagaagaa      780

aatctcaata aatctgaaat aagtcaagtg tttgagattg cacttaaacg gaacttgcct      840

gtgaatttcg agtctttccc tctgaaacag gtggcccggg agagtggccc accccacatg      900

aagaactttg tgaccaaggt ttcggttggg gagtttgtgg gggaaggtga agggaaaagc      960

aagaagattt caaagaaaaa tgccgccata gctgttcttg aggagctgaa gaagttaccg     1020

cccctgcctg cagttgaacg agtaaagcct agaatcaaaa agaaaacaaa acccatagtc     1080

aag                                                                   1083


<210> 3239
<211> 2865
<212> DNA
<213> Homo sapiens

<400> 3239
agtgcccccc gcgccccgct ccggcagctc cacgctcgcg cccgccatgc cggagcagtt       60

cagcgtcgcc gagttcctgg ccgtcaccgc ggaggacctc agctccccgg ctggggccgc      120

cgccttcgcc gccaagatgc cccggtaccg aggggcggcg ctggcgcggg aggagatctt      180

ggaaggagac caagccatcc tgcagagaat aaagaaggct gtgcgggcaa tccatagctc      240

cggccttggc catgtggaga atgaagagca gtaccgagag gccgtggaat ccttaggcaa      300

cagccacctg tcccagaaca gccatgagct gtccacaggc ttcctaaact tggccgtgtt      360

cacccgcgag gttgctgcgc tcttcaagaa cctgattcag aacttgaaca acattgtctc      420

tttccccctg gacagtctga tgaaggggca gctgagggac ggtcgacagg cttctctttc      480

cttggggtct agggccaagc tggagaagga gcgcgatcgg gccagggtga caggagggat      540

ccctggggag gtggcccagg acatgcagag agagcggcgc atcttccagc tgcacatgtg      600

tgagtatctg ctcaaagccg gggagagcca gatgaagcaa ggtcctgact tccttcagag      660

cctcatcaag ttcttccacg cccagcacaa ctttttccaa gatggctgga aggctgccca      720

gagcctgttc cccttcatcg agaagctggc ggcctcagta catgcactcc atcaggccca      780

ggaggacgag ctacagaagc tgacccagct ccgggactcc ctccgaggga cactgcagct      840

tgagagcaga gaggaacacc tgagccggaa gaactcagga tgtggctata gcatccacca      900

gcaccaaggc aacaagcagt ttgggacgga gaaagtgggc tttctataca agaaaagtga      960

cggaattcga agagtctggc agaaaaggaa gtgtggagtc aagtatggct gcctgaccat     1020

ctcacacagc acgataaacc ggcccccggt gaagctgacc ctgctgacgt gccaagtgag     1080

gccaaaccct gaggagaaaa agtgcttcga cctggtgacc cacaaccgga cgtaccactt     1140

tcaggcagag gacgagcacg agtgtgaggc gtgggtgtca gtgttgcaga acagcaagga     1200

cgaagccctg agcagcgcct tcctcgggga gcccagcgct ggcccggggt cctgggggtc     1260

cgccggccat gatggggagc cgcacgacct cacaaagctg ctcatcgcgg aggtgaagag     1320

caggcctggg aatagccagt gctgcgactg cggggctgca gaccccacgt ggctcagcac     1380

caacctgggc gtgctcacct gcatccagtg ctcgggcgtc caccgcgaac tgggcgtgcg     1440

cttttcgcgc atgcagtcac tcaccttgga cctgctgggc ccctccgagt tgttgctggc     1500

cttgaacatg ggaaacacga gcttcaatga ggtcatggag gcccagctac cctcacacgg     1560

cggccctaaa ccctcagctg agagtgacat gggcacccgc agggactaca ttatggccaa     1620

gtatgtggag cataggtttg cacgccggtg cacacctgag cctcagcgac tctggacagc     1680

catttgcaac agggacctcc tgtcggtact ggaggccttt gccaatgggc aggactttgg     1740

acagccgctg ccagggcctg atgcacaggc acctgaagaa ctcgtcttgc atttggctgt     1800

caaagtcgcc aaccaggctt ccctgcctct ggtggatttc atcatccaga acggtggtca     1860

cctggatgcc aaggctgctg acgggaacac ggctctgcac tacgcagcac tctacaacca     1920

gcccgactgc ctcaagctgc tgctgaaggg gagagctttg gttggcacag taaatgaagc     1980

aggcgagaca gctctggaca tagccaggaa gaagcaccac aaggagtgtg aggagctgct     2040

ggagcaggcc caggcgggga cctttgcctt ccctctacat gtggactact cctgggtaat     2100

ttccacagag cctggctctg acagtgagga ggatgaggaa gagaagcgct gcttgctgaa     2160

gctcccggcc caggctcact gggccagtgg gaggctggac atcagcaaca agacctatga     2220

gactgtcgcc agcctgggag cagccacccc tcagggcgag agtgaggact gtcccccgcc     2280

cttgccagtc aaaaactctt ctcggacttt ggtccaaggg tgtgcaagac atgccagtgg     2340

agatcgttct gaagtctcca gcctgagttc agaggcccct gagacccctg agagcctggg     2400

cagtccagcc tcctcctcca gtctgatgag ccccttggaa cctggggatc ccagccaagc     2460

cccacccaac tctgaagagg gcctccgaga gcccccaggc acctccagac ccagcctgac     2520

atccgggacc accccttcgg agatgtacct ccccgtcaga ttcagctccg agagcactcg     2580

ctcctatcgg cggggggcgc ggagccctga agatggtccc tcagccaggc agcctctgcc     2640

cagaaggaac gtgccggttg gcatcactga aggagatggc tcaaggactg ggagtctccc     2700

agcaagttct gtgcaacttt tgcaagacta gctccttgct ggcccccaca tgccccatgc     2760

taggccccaa tgttcagagc tgggacttga gctcacaaaa ctggggagct gagacatttg     2820

ttctcttgga tctcactctc tctgtccctt gtgcctctgt agctg                     2865


<210> 3240
<211> 1220
<212> DNA
<213> Homo sapiens

<400> 3240
cagtgtttat agcatagtcc actgggactg ccgctctgac aaagactgtg tcactacttt       60

gtggaatgtt attttagaac ttccagaatg cctcagtaaa tcctgactgc catgtaactg      120

tgtactgtgc tgctgagctc ttaacatgaa gcagcagcag tgaccctggc gggccaggct      180

gacgtgcgtg ggaacagtgg gagtgaccct ggctgggaag cagggaggcc tggatattgt      240

ttctcctggc tctgtgtcct gccattctca tccctgtgct cagagctctc aagcacccac      300

gatggccttc tcaggccgag cgcgcccctg cattatccca gagaacgaag aaatcccccg      360

agcagccctt aacactgtcc acgaggccaa tgggaccgag gacgagaggg ctgtttccaa      420

actgcagcgc aggcacagtg acgtgaaagt ctacaaggag ttctgtgact tttatgcgaa      480

attcaacatg gccaacgccc tggccagcgc cacttgcgag cgctgcaagg gcggctttgc      540

gcccgctgag acgatcgtga acagtaatgg ggagctgtac catgagcagt gtttcgtgtg      600

cgctcagtgc ttccagcagt tcccagaagg actcttctat gaggaacgaa cgtgatggtt      660

aagctacctt cattaagcag catgaccgct tcctgagctc ctgctgccgc atttaggccc      720

tgtcagctgt gaggccactg gtgctgagtc agagggaaaa gctcagaaca gccttgagca      780

gcgaagaata aagcatgact catctcgtcc tgcccacccc tcacactgga ctataaatac      840

cctccctggg tctgtgtgct gttattccaa aagatgcgat gaatacccag aactaggcta      900

ttcatgggct gttgcccagt tcaagctcta ttgggtcctg aggaagatta ctattttggc      960

tacattgttt atcattaaaa ccagcccagg gatgtgtaaa cctgcatctg gagaataaga     1020

catttctttt tggttaaatg atattagaga aaaaaaaaac tatccaaggc tgctaacaaa     1080

taatcttcac tttcaattat atccagcaat aagttgttct ccagaaaaga aagcttggaa     1140

acttacccag tttgccttcc atttgggaca tgactgatgt gcttcagtct ttgtataata     1200

aatgcatctt cgccactcta                                                 1220


<210> 3241
<211> 2007
<212> DNA
<213> Homo sapiens

<400> 3241
gtgatttggc gggagtcttg accgccgccg ggctcttggt acctcagcgc gagcgccagg       60

cgtccggccg ccgtggctat gttcgtgtcc gatttccgca aagagttcta cgaggtggtc      120

cagagccaga gggtccttct cttcgtggcc tcggacgtgg atgctctgtg tgcgtgcaag      180

atccttcagg ccttgttcca gtgtgaccac gtgcaatata cgctggttcc agtttctggg      240

tggcaagaac ttgaaactgc atttcttgag cataaagaac agtttcatta ttttattctc      300

ataaactgtg gagctaatgt agacctattg gatattcttc aacctgatga agacactata      360

ttctttgtgt gtgacaccca taggccagtc aatgtcgtca atgtatacaa cgatacccag      420

atcaaattac tcattaaaca agatgatgac cttgaagttc ccgcctatga agacatcttc      480

agggatgaag aggaggatga agagcattca ggaaatgaca gtgatgggtc agagccttct      540

gagaagcgca cacggttaga agaggagata gtggagcaaa ccatgcggag gaggcagcgg      600

cgagagtggg aggcccggag tggctctggg agtgaacctg tggccgctgc attggagaag      660

agctccaggt tgttcgccgg tcccatgagt gacaggacag ccccaaggtc tcccagaaga      720

gacatcctct ttgactacga gcagtatgaa tatcatggga catcgtcagc catggtgatg      780

tttgagctgg cttggatgct gtccaaggac ctgaatgaca tgctgtggtg ggccatcgtt      840

ggactaacag accagtgggt gcaagacaag atcactcaaa tgaaatacgt gactgatgtt      900

ggtgtcctgc agcgccacgt ttcccgccac aaccaccgga acgaggatga ggagaacaca      960

ctctccgtgg actgcacacg gatctccttt gagtatgacc tccgcctggt gctctaccag     1020

cactggtccc tccatgacag cctgtgcaac accagctata ccgcagccag gttcaagctg     1080

tggtctgtgc atggacagaa gcggctccag gagttccttg cagacatggg tcttcccctg     1140

aagcaggtga agcagaagtt ccaggccatg gacatctcct tgaaggagaa tttgcgggaa     1200

atgattgaag agtctgcaaa taaatttggg atgaaggaca tgcgcgtgca gactttcagc     1260

attcattttg ggttcaagca caagtttctg gccagcgacg tggtctttgc caccatgtct     1320

ttgatggaga gccccgagaa ggatggctca gggacagatc acttcatcca ggctctggac     1380

agcctctcca ggagtaacct ggacaagctg taccatggcc tggaactcgc caagaagcag     1440

ctgcgagcca cccagcagac cattgccagc tgcctttgca ccaacctcgt catctcccag     1500

gggcctttcc tgtactgctc tctcatggag ggcactccag atgtcatgct gttctctagg     1560

ccggcatccc taagcctgct cagcaaacac ctgctcaagt cctttgtgtg ttcgacaaag     1620

aaccggcgct gcaaactgct gcccctggtg atggctgccc ccctgagcat ggagcatggc     1680

acagtgaccg tggtgggcat ccccccagag accgacagct cggacaggaa gaactttttt     1740

gggagggcgt ttgagaaggc agcggaaagc accagctccc ggatgctgca caaccatttt     1800

gacctctcag taattgagct gaaagctgag gatcggagca agtttctgga cgcacttatt     1860

tccctcctgt cctaggaatt tgattcttcc agaatgacct tcttatttat gtaactggct     1920

ttcatttaga ttgtaagtta tggacatgat ttgagatgta gaagccattt tttattaaat     1980

aaaatgctta ttttaggctc cgtcccc                                         2007


<210> 3242
<211> 4426
<212> DNA
<213> Homo sapiens

<400> 3242
atgccatcgg aaaagaaaat tagcagtgca aatgactgca tcagcttcat gcaagctggc       60

tgtgagttga agaaagtccg gccaaattct cgcatttaca accgtttttt cactctggac      120

acagaccttc aagctcttcg ctgggaacct tcaaagaaag acctcgagaa agccaagctt      180

gatatttctg ccataaaaga gatcagactg gggaaaaaca cggaaacatt tagaaacaat      240

ggccttgctg accagatctg tgaggactgt gccttttcca tactccacgg ggaaaactat      300

gagtctctgg acctagttgc caattcagca gatgtggcaa acatctgggt gtctgggtta      360

cggtacctgg tttctcgaag taagcagcct cttgatttta tggagggcaa ccagaacaca      420

ccacggttca tgtggttgaa aacagtgttt gaagcagcag atgttgatgg gaatgggatt      480

atgttggaag acacctctgt agagttaata aaacaactca accctactct gaaggaagcc      540

aagatcaggt taaagtttaa agaaatccag aagagcaagg aaaaactaac cacccgcgtg      600

accgaagagg aattttgtga agctttttgt gaactttgca ccaggccaga agtgtatttc      660

ttacttgtac agatatctaa aaacaaagaa tatttggatg ccaatgatct catgctcttt      720

ttagaagctg agcaaggagt cacccatatc accgaggata tatgcttaga catcataagg      780

agatacgaac tttctgaaga gggacgtcaa aaagggtttc ttgcaattga tggctttacc      840

cagtatttat tgtcatcaga atgtgacatt tttgatcctg agcaaaagaa ggttgcccaa      900

gatatgaccc agccattatc tcactactat atcaatgcct ctcataacac ctatctaata      960

gaagaccagt tcagggggcc agctgacatc aatgggtaca ttagagcttt gaaaatgggc     1020

tgtcgaagcg ttgaactcga tgtaagtgat ggttcagata atgaaccaat cctttgtaat     1080

cgaaataaca tgacaaccca tgtttccttt cgaagtgtca tagaggtaat aaataaattt     1140

gcctttgttg cttctgaata cccactcatt ctttgcttgg gaaatcactg ctccttgccg     1200

cagcagaagg taatggctca acagatgaaa aaggtctttg gcaataaact ctatactgaa     1260

gcacctttgc cctcagaatc ctacctccca tcaccagaaa aattaaaaag aatgatcatt     1320

gtgaaaggaa agaagttgcc ttctgatcca gatgtgttag aaggagaagt aacagatgaa     1380

gatgaagaag ctgaaatgtc tcgaaggatg tcggtagatt acaatggtga gcagaagcaa     1440

atccgactct gtagggagct ctctgatttg gtgtctattt gtaaatctgt tcaatacagg     1500

gattttgaac tatctatgaa aagccaaaac tattgggaaa tgtgttcatt tagtgaaaca     1560

gaggccagcc gcattgcaaa tgagtaccca gaggattttg ttaattataa taagaagttc     1620

ttatcaagaa tctatccaag tgccatgagg atcgattcca gtaacttgaa tccacaggac     1680

ttttggaatt gtggctgtca gattgtagca atgaattttc agactccggg tccaatgatg     1740

gaccttcaca cgggctggtt tcttcaaaac gggggatgtg gttatgttct aaggccgtct     1800

ataatgcgag atgaagtttc ttacttcagc gcaaatacaa agggcattct acctggggtg     1860

tctcctctag ctcttcatat caagatcatc agtggtcaga atttcccaaa gcccaaggga     1920

gcttgtgcca aaggggatgt catagatccc tatgtttgta tagagataca cggaattcca     1980

gcggattgtt cggaacaaag aactaaaact gtacagcaaa acagtgataa tcctattttt     2040

gatgaaactt ttgagttcca agtaaaccta cctgagctgg ccatgatccg ttttgttgtt     2100

ctggatgatg actacattgg ggatgagttt atagggcaat atacgatacc atttgaatgt     2160

ttgcagcctg gatatcggca tgttcccctg cgttcttttg tgggtgacat catggagcac     2220

gtaacccttt ttgtccacat agcaataact aatcgaagtg gaggaggaaa ggcacagaag     2280

cgcagtcttt cagtgagaat ggggaagaaa gttcgggaat ataccatgct caggaatatc     2340

ggtcttaaaa ccattgatga catctttaaa atagcggttc atccattacg agaagccata     2400

gatatgagag aaaatatgca gaatgcaatc gtgtctatta aggaactatg tggactccct     2460

ccaattgcca gtctgaagca gtgcctgtta actctgtcat ctcggctcat caccagtgac     2520

aatactcctt cagtctcact tgtgatgaaa gacagctttc cttacctgga gcctctgggt     2580

gcaattccag atgtgcagaa aaagatgctg actgcttatg atctgatgat tcaagagagc     2640

cggtttctca tagaaatggc ggacacagtc caggaaaaga ttgtacagtg tcagaaagca     2700

gggatggagt tccatgaaga acttcataat ttgggggcaa aagaaggctt gaagggaaga     2760

aaactcaaca aagcaactga gagctttgct tggaacatta cagtattgaa gggccaagga     2820

gatctgttga agaatgccaa gaatgaagct atagaaaaca tgaagcagat ccagctggca     2880

tgcctgtcct gtggactgag taaagccccc agcagcagtg ctgaggccaa gagcaagcgc     2940

agcctggaag ccatagagga gaaggaaagt agtgaggaga atgggaagct gtgactctgg     3000

gcattatcga cacgttcacc catcttatca aggactctgg tttctcattc ttgttttctt     3060

tctttaaatg ttttataagt tcacaaaatg gtgccctata tggggtattg gacatagata     3120

ttttcacaat gtcagtattt cagtgtagtt aatttatcta aattaaagcc tttagtatca     3180

gtgttttaaa ttctgagaca tgtgtcaaca cccctgtgtg gatgcctgtg gaagagtgtg     3240

tgtgtgtgtg tgtgtgtgtg tgtgtggcag agagagagaa agagagagag agagagaaat     3300

tctgttaaaa tctattctgt gttgcattat tcatttagtg agttattcct tgatcatttt     3360

gggacaattg ttttaatctg aaattctaaa gagcacttac tgtaacctgt tgctgtgttt     3420

aatttgactt ctctgccttt gacatttaat ttagtgatct tagcatagct tattattgaa     3480

ggaagccaaa tttatcaaag catagatgtt ttggtagatt aaatatagat tagaaaaatt     3540

cctaagaatc agagtagaaa taaaagtgaa tgaaagatta aacagatgat gagaatttct     3600

aaaaagatta gcaaggtcat ttcttcagtc agaaaacttt aaaaaatatt tattaaataa     3660

aatcaatttt taggaagttt tctgtagtca tttactaaac atatgatttc actagaaaag     3720

ctgatcataa gtgaatttat acctacctgt gtggtactct gaaacacact gaaagctctg     3780

ttgcaattag gattttgatg tgacaataat attgttgtat aatttcgaga tttgtaggaa     3840

ggtctcattc ttccaagctg agagtctagc actcattttc tataacagat atggcagctt     3900

agaggtgttg gctttgtttg gatgtaattt agggtactaa atttaaattt aaagatattg     3960

ttcaaacaat atcatatcat cacattgagc tgatataaat tctgtgggtc cgataatatc     4020

tttgtgataa tttaagagct aaccagttac cacacatcta tgatataacc ctaacacaca     4080

cagaaaagca tacatgcaaa aagaaatgac taattagggt acatttataa ttgcatctag     4140

gtaattttta ccctaatgtc ttcataaagt acttgagtgt aatgtttgtt acctccaaca     4200

gaactaaatg ttctatggtt atgaaagaat atatttattt aaagcattgc ttttattttg     4260

aaaagcttct taattaattt gattaacaaa tatgctaatt tggggaaacc tagagaagat     4320

aattgttgaa attttgcaaa tataaacatc tcctatagct tctgtgttat ttctgacttc     4380

ttaacactat tatgtttatg ttgcacatta ctgaaagagt aaagat                    4426


<210> 3243
<211> 787
<212> DNA
<213> Homo sapiens

<400> 3243
aattagctgg catggtggtg cacgcctgtg gtcccagcta cccgggaagc tgaagtggga       60

agatctattg agcctgggag gttgaggcta cagtgagctg tgactgcgct tgaacctgtg      120

cctgcgcttg aacctgtgcc tgaatactac cctagacagt gtggacaaca gtgagtatat      180

gcggaatgga gacttcttac ccaccaggct gcaggcccag caggatgctg tcaacatagt      240

ttgtcattca aagacccgca gcaaccctga gaacaacgtg ggccttatca cactggctaa      300

tgactgtgaa gtgctgacca cactcacccc agacactggc cgtatcctgt ccaagctaca      360

tactgtccaa cccaagggca agatcacctt ctgcacgggc atccgcgtgg cccatctggc      420

tctgaagcac cgacaaggca agaatcacaa gatgcgcatc attgcctttg tgggaagccc      480

agtggaggac aatgagaagg atctggtgaa actggctaaa cgcctcaaga aggagaaagt      540

aaatgttgac attatcaatt ttggggaaga ggaggtgaac acagaaaagc tgacagcctt      600

tgtaaacacg ttgaatggca aagatggaac cggttctcat ctggtgacag tgcctcctgg      660

gcccagtttg gctgatgctc tcatcagttc tccgattttg gctggtgaag gtggtgccat      720

gctgggtctt ggtgccagtg actttgaatt tggagtagat cccagtgctg atcctgagct      780

ggccttg                                                                787


<210> 3244
<211> 556
<212> DNA
<213> Homo sapiens

<400> 3244
atcgtcttaa ggaggtattt ggtggaggct ctttgaagtt gggttcagga gtgtagaatt       60

ggcaaagtta ttgccagctt cctgggttat atcctgtgtt gtgacctcat ggtttaagtg      120

ggaataaaga tgagtataag cagtgatgag gtcaacttct tggtatatag atacttgcaa      180

gagtcaggat tttctcattc agcatttacc tttggtatag aaagccatat cagtcagtcc      240

aatataaatg gtgccctcgt cccacccgct gcattgattt ctatcatcca gaaaggtcta      300

cagtatgtag aagcagaagt tagtattaat gaggatggta ccttgtttga tggtcgacca      360

atagagtctc tgtccctgat agatgccgta atgcctgatg tagtacaaac aagacaacaa      420

gcttatagag ataagcttgc acagcaacag gcagcagctg ctgcagctgc cgcagctgca      480

gccagccaac aaggatctgc aaaaaatgga gaaaacacag caaatgggga ggagaatgga      540

gcacatacta tagcaa                                                      556


<210> 3245
<211> 1736
<212> DNA
<213> Homo sapiens

<400> 3245
agacacgccg ggctctcggg gcaccacagc catgtgctcg ttagcgtcag gcgctaccgg       60

ttattcacat ctgctgaaga aacattttca cactgtaagt ctgagcatca gtttaatatt      120

gacagcatgg ttcataaaca tgaatcctac agttgagtac atgaattcca tatacaaccc      180

agtgccttgg gagaaagaag agtatttgaa gccagtatta gaagatgacc ttttacttca      240

atttgatgta gaagatcttt atgaaccggt gtcagtaccc ttctcatacc ccaatggact      300

cagtgaaaat acatctgttg ttgaaaaatt gaaacatatg gaagccaggg cactgtctgc      360

tgaagccgca ttggccagag cacgtgagga tctgcaaaaa atgaaacaat ttgctcagga      420

ttttgtgatg cacacagatg tcagaacctg ctcgtcatct actagtgtca ttgcggacct      480

ccaggaggat gaggatggtg tttatttcag ctcatacggg cattatggga tacatgaaga      540

aatgctaaag gacaaaatac gaacagaaag ctaccgagat ttcatatacc aaaatccaca      600

tatcttcaaa gacaaggtag ttttggatgt tgggtgtgga actggaattc tctctatgtt      660

tgctgctaaa gctggggcga agaaggttct tggagttgat caatctgaaa tactttacca      720

ggcaatggat attataagac taaataaact tgaagatact attacactaa ttaaaggaaa      780

gattgaagaa gttcatcttc ctgtagaaaa agtagatgtt atcatatctg agtggatggg      840

ctattttctt ctgtttgagt ctatgttaga ttctgtcctt tatgcaaaga acaaatactt      900

ggcaaaagga ggctcggtct accctgacat ttgcactatc agccttgtag cagtgagtga      960

tgtgaataaa catgctgata gaattgcttt ttgggatgat gtctatggct tcaagatgtc     1020

ctgcatgaag aaagcagtta ttccagaagc tgttgtggaa gttttagatc cgaagactct     1080

tatttcagaa ccttgtggta ttaagcatat agattgccat acgacgtcta tctcagattt     1140

ggaattttca tcagatttta ccctgaaaat cacaaggaca tccatgtgca cggcaattgc     1200

tggctacttt gatatatatt ttgagaagaa ttgccacaac agggtcgtgt tctctacggg     1260

ccctcagagc accaaaacac actggaaaca aacagtattt ctactggaaa aaccattttc     1320

agttaaagca ggtgaagcct tgaaaggaaa ggtcacagtt cacaagagta agaaagatcc     1380

acgttctctc accgtgaccc tcacgttgaa taattcaact caaacttatg gtctccagtg     1440

aaacagccat aaaagcacac taccttgtag tttttaatgt gggggtagag tgggtcagca     1500

ggagggagct ggttttatgt gagcagatgg atggatgatg gaccctttcc taatgagcct     1560

cctcaataag agagaagttc tcattgtggg aatctgacat agttcagctg aggaagagaa     1620

tcagctgatc ctcatggtct gccacgtaat cattttctta gacgtttgct ccaccagatt     1680

taaccaaatg taactcccac attgagttta tctatattga aaatcattta cattgg         1736


<210> 3246
<211> 747
<212> DNA
<213> Homo sapiens

<400> 3246
gtgcgcttgt cacgcgtggc ggtgcgtggt tgctaggggc gcctgaggct gccgggtagc       60

ccagcaggcc gagggaggaa gtagcgtgga gccggtgccg agccggggcg aagctggatc      120

ccctagactg acagacttca aggatgcagc tgctactacc ggaggtgtgt ggcaccttac      180

ctcagcaagg ccatgagacc gtgtggccat gatgtgggcc cctcatggcc tcagcaggaa      240

cacagcacta tagtattggc ctccgccaga aaaacagctt caagcagagt ggtccctcag      300

gcacagtacc tgccacgcca cctgagaaac cctcggaggg cagagtctgg cctcaggccc      360

atcagcaagt gaagccaatc tggaagctgg aaaagaagca agtggagaca ctgtcagcag      420

ggttgggccc aggcctcttg ggcgtcccac cccagccagc atatttcttt tgccccagca      480

ctttatgtag ctctgggacc acggctgtca ttgcaggcca cagcagttcc tgttacctac      540

actctctccc ggacttgttc aacagcaccc tgctataccg ccgctccagc tataggcaaa      600

aaccgtacca gcaactggag tctttctgct tgcgttcgag cccgtcagaa aaaagccctt      660

tttctctccc tcaaaagagc ctccctgtca gtctcactgc caacaaggcc acttcttcca      720

tggtcttctc catggcccag cccatgg                                          747


<210> 3247
<211> 3691
<212> DNA
<213> Homo sapiens

<400> 3247
atgcagaagg aaagagagct ccaggagacc atatatttca agaacacgtg gcctgcttgt       60

atgttcttaa tagttgctcc tctttctgtc ctctacaact ggaaggatga attggacacc      120

tggggatatt tcagagtcac tgttttacat ggaaacagaa aagataatga attaattcgt      180

gtaaagcaga ggaaatgtga aattgctcta acaacttatg aaacactacg cttatgcctg      240

gatgaactta acagtttgga atggtcagct gtcattgtgg atgaagctca tagaatcaag      300

aatccaaaag ctagagtaac agaagttatg aaagctttga aatgtaatgt ccgcattggc      360

ctcactggaa ccatccttca gaacaacatg aaggaactgt ggtgtgttat ggactgggct      420

gtgccaggcc ttttagggag tgggacctac ttcaagaagc agttttctga cccagtagaa      480

catggtcaga gacacacggc aacaaagaga gaactagcca ctggccgaaa ggccatgcaa      540

agacttgcca aaaagatgtc tggctggttt ctcaggcgca ccaagactct tatcaaggat      600

cagttgccta agaaggaaga ccggatggtg tattgttctt tgacagattt ccagaaagct      660

gtctatcaaa cagtgttaga aacagaggac gtgactttga tacttcaatc ttctgagcct      720

tgtacctgta ggagtggcca aaaaaggaga aattgttgtt ataagaccaa ttctcatggt      780

gaaacagtga aaaccttgta tctcagttac cttacagtcc ttcagaaggt agctaaccat      840

gtcgcgctac tgcaagctgc tagtacttcc aaacaacagg aaacacttat caaaaggata      900

tgtgatcagg tattttccag attcccagat tttgtgcaga aaagcaaaga tgcagccttt      960

gaaacacttt ctgaccctaa atacagtgga aaaatgaagg tccttcagca gcttttaaat     1020

cattgcagga aaaacagaga taaagttctt ctcttttctt tttccaccaa gttgcttgac     1080

gtgctacagc agtactgtat ggcgtctggg cttgattacc gacgacttga tggaagtaca     1140

aaatcagagg aaagactcaa gattgtaaaa gagttcaaca gtacacaaga tgttaacatt     1200

tgccttgtct ctacaatggc tggtggacta ggcctcaatt ttgtcggtgc caatgttgtt     1260

gtattatttg atcctacttg gaatccagcc aatgatcttc aagccattga cagagcatat     1320

aggattggac aatgtagaga tgtcaaagtg cttaggctga tatccttggg aactgtggag     1380

gaaatcatgt atttacgaca gatatacaag cagcaacttc actgtgtggt ggttggaagt     1440

gaaaatgcca aacgatattt tgaagcagtt caaggatcta aagagcatca aggagagctt     1500

tttgggatcc ataacctctt caaatttagg tcccaagggt cttgtcttac gaaggacatc     1560

ctggaggtgt gaacttcttc tctgaccttt tcaataatat tttaaataca gtttttcttc     1620

ctcaggaaat ctgaaataca attgctgttg ccttttcaga gaaacttttg gttttcttta     1680

tcaaaaatgc cttggaattt ttacttttag agaataagaa atgaattatt gtacctctaa     1740

actaagattt tcccatgcat aattacaaat aatgcacaca cacaaatgta tatgctgggt     1800

agtatgaact ccaaggcaat tttaaatagg cagagagaag tttatagttt tgaaaacagc     1860

tgctgaagtc aggaactaaa aaaagaggtt ttcctaaata aacaaaaata taaaatgtgt     1920

tttaattaaa agttaccaaa tactccctga gatgtactct catgtctcat ggagattttt     1980

gttttctgtt cccaataaaa attccacacc agtattttaa actctccctg ttgtgttcat     2040

cctcagcata cagatgtttc ttattcctca aacaaaatat tttatatcct tttttaaaaa     2100

aatctttaag ttcttttata taccggaata ctaaggatat taacctattt tctaattgat     2160

attcatatag gtatcataaa atcctggagt atcatctttt tcaacctcct catggtatag     2220

atgaggaaac tgagtcttag agaacttcag gatatttctc ttgacttcca ggactttgta     2280

gtaaaatctt aatgtacttc atttattcag taagtaccat aaaggcagtt caaggagcaa     2340

ttggttcctg tccttgagga acttaaacca tcttgaccgg aggtggaaga gaacgtttac     2400

ataataacca tgcaatgtca ggaatcgtat gctgaacaag ttaaacagta gaccatggat     2460

ggctggggga gaggaaggta tatattattt gaatcctata aatgttgtta ctattataca     2520

gtttctgata tatactgctg agtttctatt ttatagtaac tatatttgat tctgaattca     2580

gtggcccatt tggagtccta ctttttgggg ttttttcccc ttgcttttta aatacgctgt     2640

ttctttcatg aatttgttct ttccagtttc ccttttcata tcaataactt tgtttgccct     2700

ccagctccca aacccagctg ctacctccat ctcagagtac tacttgacat gcctatattg     2760

atgttaaagt caattgtcta taaaaatatt agcattttat tatttatcct gttttctgtc     2820

atatatgaca tagttacctg tttttatcag aataaccacc tatttctttg ttaaacaagt     2880

gttatataag acatatcagg atgacaggtt attaagtaga aaaagttccc ttgtttatcg     2940

tgccactgca ctccagcctg gggaacaaag caagagactt gtctcaaaaa caaaaaacaa     3000

aaacaaaaaa aagttctctt gttcactggt tattctaaga atatcttgtt tcaccttcag     3060

aagtgtttat taatgacagg accatccatg tcttacattt tcttttttaa aaatatcttt     3120

taagttcttt aatataccag aacactaaga atattaacct attttctaat tgatattaat     3180

aaggggtgac aaggccatcc atgccctaca tttgtcttgc taggcatatc attggcactt     3240

gattattaag ttaaattttg aattaaaatt actcatttgt catcaatcag aatgtaaatt     3300

tattcaggat tggttagatt catgctgctt tgggccaaaa ggtgcttcta aatattatta     3360

ttagccccat ataatgggag tacctatcat aaagtaaaag gagtatttca cttcatgtga     3420

gacattttta atttttaaag gttgtataaa atctctttta aaatgtttta agatgtaaaa     3480

atttgaatat ttacacttat aatcttatga tttctgggca atttcattct gttttgcatt     3540

gactttccat tatctatatt atggtttctc ttcaaagata gatattgaga gttcatttta     3600

caagtatttg ttgagcatct gctaaatgtc aggtactgtt catagagctt tgcatacata     3660

aaagaacaaa ataaacaaaa cgatcctgtc t                                    3691


<210> 3248
<211> 2870
<212> DNA
<213> Homo sapiens

<400> 3248
gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc ctgactcaca       60

ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg ggatgggaac      120

aacatgtctt cacctaggga ctttagagca gagcctggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct      540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaaca gataccgaga      600

tattcttcca tatgattcaa cacgcgttcc tcttggaaaa agcaaggact acatcaatgc      660

tagttatatt agaatagtca attgtggaga agagtatttt tatatcgcta ctcaaggacc      720

actgctgagc accatagatg acttttggca aatggtgttg gaaaataatt caaatgttat      780

tgccatgata accagagaga tagaaggtgg aattatcaaa tgctaccatt actggcccat      840

ttctctgaag aagccattgg aattgaaaca cttccgtgta ttcctggaga actaccagat      900

acttcaatat ttcatcattc gaatgtttca agttgtggag aagtccacgg gaactagtca      960

ctctgtaaaa cagttgcagt tcaccaagtg gccagaccat ggcactcctg cctcagcaga     1020

tagcttcata aaatatattc gttatgcaag gaagagccac cttacaggac ccatggttgt     1080

tcactgcagt gccggcatag gccggacagg ggtgttccta tgtgtggatg tcgtgttctg     1140

tgccatcgta aagaactgtt cattcaacat catggatata gtggcccaaa tgagagaaca     1200

acgttctggc atggttcaaa cgaaggagca gtatcacttt tgttacgata ttgtgcttga     1260

agttcttcgg aaacttctga ctttggatta agaaagactt ctgttgcctc tcacttgaaa     1320

ttaccaagtg ggtttgcacc tcctcataaa gaacatgttt gcactgtgct gaagggcttt     1380

gctatgcata caatctgctt tcttggttta tcagtttatt ttctttctaa aagctccctg     1440

aagggcaata tcatttggct tggggtgatc agtgtttact tattgatctt gctagacaat     1500

atcaaaataa cttcccacat tttccagtga aacagatgtt acataaaacg attgcagctt     1560

ggctatttgg ttgaagggat tacagagccc aataaaggat ttaaaatata ttcattaaga     1620

ttttatttgg aaaggtggct ggagagagct gaggatttcc aggactttgt aagttcttat     1680

tctgggagaa cataaggcca ataatcatga cctcttccag gcatttttaa gacagatgtc     1740

tattcatgtt ctttagctag agcctgtact ttttgctggc atttgaataa cccagtttaa     1800

aaagagtcca gttagggtgg actaactttg gacacaaatt ggcttccatt tcctacattt     1860

tcatactgct gccttcctac agctgctaga ccaagacctg ttggtctggg aagcatttca     1920

tggataggga gagctcctct cggtgaacag tccaaaacta aaatagatgt ttatatagaa     1980

agcccaagag gagatttttg ccatgcctga gttctttcct atcccaccct aacacttaac     2040

atattactta gtctgctttg ttaaaagcaa gtattacctt taacttgcct cttactcttt     2100

gccctttagc taactaataa agtttgatat aggcattatt atataattct gagtcattca     2160

tggtatatct catgtttgat gtatttttca aactaagatc tatgatagtt ttttttccag     2220

agttccatta aatcatttat ttcctttact ttctcacctc tgttgaaaca tttagaaact     2280

ggatttggga acccaatttt ggaaaaccag attcatagtc atgaaaatgg aaacttccat     2340

attctgtttt tgaaaagatg tggccattat tacagtaatt ttattatagg actttgcctc     2400

gtacaattaa tagtgatatt ttggacaagg agttctggtg acaagctata cctaattata     2460

agctataaaa caatagatat gagtgtttgt acagtttaac tcaatggaga tcagaatatt     2520

ctatgtattg agaaaatgtt taatatcaat ctataaatct tgaatttcta agaggcttat     2580

tttgttcttt tggctgaatg agtatatttg aattggttga ataattaata attctcattg     2640

taaaaataat tatatgccaa aaatatattt gatgttaaat caaatagatg attctgttta     2700

cattgttcat atgaataata atctgtgtta atttcatttt gataattggc ctttaatatt     2760

tgtatctcta attttatttt ctctctgtta ctgtaaaata atagctataa tgtataacaa     2820

ttttcttcag aagaattcta tgctattatt aaaataaaat atttactgtg                2870


<210> 3249
<211> 3139
<212> DNA
<213> Homo sapiens

<400> 3249
gtcggtgcct gcagggctct ccgtggccgc tcgggagagg tgctcttcgc tcaggctccc       60

ccggagactt gagggggtgc gcgctggcgt gcatggggcc tgttctgtcc ttggtttggg      120

gatgctccta aggggggaga aagggatacc tcgggtgctt ggaggtcgag agacggatac      180

gtaagtgcgc aagggccact gattagggca cgggaagggc tcgctagaat gagctcttaa      240

actggttggg tgtaagcggt tttgggctag tctaaaccaa acaactgaga ataaacgcgg      300

ggttcctgca ggttgagaga gtacctgtct gcaaatgtcc agtagtgatg gattgccttg      360

taggccccag agcaatcggg gaagttagca ttcttgttca agaagctgct ggttcactta      420

gagctataaa agaatgttgt gagtttggat tttcttccaa acgttcagga ttgaggttag      480

ggctggtggt gagggatcat gtaaagaggt ttgagtggct cagccttagg tcccggtgtg      540

gaaagcttat tcttttggtg tcatcacgtg gccgtgggaa ttatttagaa tgtgatctgc      600

cctcatgaga agaaaggagc tctgaagccg ttgcagttct tcctccctat gtggaaaatc      660

gaatttctgg aaacatcctc cgtattggga gattttgcct atgtaaaggc tatccttatt      720

ggctagcggc actaattact ttaaaagtag gatggaagta caagtatctc aagcatcatt      780

gggtttcgag ctcacttctg tggaaaagag tttaagggag tggtctagac tttccaggga      840

agttattgcc tggctgtgtc cctctagtcc taattttata cttaactttc ccccacctcc      900

ttcagcctca tctgtttcaa tggtgcaact cttttcatcc ccttttggtt accagtcacc      960

ttcaggccat tcagaggagg aaagagaggg gaatatgaag tcagccaagc cccaagtgaa     1020

ccacagtcag catggggaaa gccagcgggc cttgagcccc ctgcagtcta ctctgagttc     1080

tgctgcatct ccttcccaag cgtatgagac ctatattgaa aatggactca tatgccttaa     1140

acacaaaatt agaaacatcg agaaaaagaa gctcaaactg gaggattata aggatcgcct     1200

gaaaagtgga gagcatctta atccagacca gttggaagct gtagagaaat atgaagaagt     1260

gctacataat ttggaatttg ccaaggagct tcaaaaaacc ttttctgggt tgagcctaga     1320

tctactaaaa gcgcaaaaga aggcccagag aagggagcac atgctaaaac ttgaggctga     1380

gaagaaaaag cttcgaacta tacttcaagt tcagtatgta ttgcagaact tgacacagga     1440

gcacgtacaa aaagacttca aagggggttt gaatggtgca gtgtatttgc cttcaaaaga     1500

acttgactac ctcattaagt tttcaaaact gacctgccct gaaagaaatg aaagtctgag     1560

tgttgaagac cagatggagc agtcatcctt gtacttttgg gaccttttgg aaggtagtga     1620

gaaagcagtg gtaggaacga catacaaaca cttgaaggat ctactgtcta aattgctgaa     1680

ctcaggctat tttgaaagta tcccagttcc caaaaatgcc aaggaaaagg aagtaccact     1740

ggaggaagaa atgctaatac aatcagagaa aaaaacacaa ttatcgaaga ctgaatctgt     1800

caaagagtca gagtctctaa tggaatttgc ccagccagag atacaaccac aagagtttct     1860

taacagacgc tatatgacag aagtagatta ttcaaacaaa caaggcgaag agcaaccttg     1920

ggaagcagat tatgctagaa aaccaaatct cccaaaacgt tgggatatgc ttactgaacc     1980

agatggtcaa gagaagaaac aggagtcctt taagtcctgg gaggcttctg gtaagcacca     2040

ggaggtatcc aagcctgcag tttccttaga acagaggaaa caagacacct caaaactcag     2100

gtctactctg ccggaagagc agaagaagca ggagatctcc aaatccaagc catctcctag     2160

ccagtggaag caagatacac ctaaatccaa agcagggtat gttcaagagg aacaaaagaa     2220

acaggagaca ccaaagctgt ggccagttca gctgcagaaa gaacaagatc caaagaagca     2280

aactccaaag tcttggacac cttccatgca gagcgaacag aacaccacca agtcatggac     2340

cactcccatg tgtgaagaac aggattcaaa acagccagag actccaaaat cctgggaaaa     2400

caatgttgag agtcaaaaac actctttaac atcacagtca cagatttctc caaagtcctg     2460

gggagtagct acagcaagcc tcataccaaa tgaccagctg ctgcccagga agttgaacac     2520

agaacccaaa gatgtgccta agcctgtgca tcagcctgta ggttcttcct ctacccttcc     2580

gaaggatcca gtattgagga aagaaaaact gcaggatctg atgactcaga ttcaaggaac     2640

ttgtaacttt atgcaagagt ctgttcttga ctttgacaaa ccttcaagtg caattccaac     2700

gtcacaaccg ccttcagcta ctccaggtag ccccgtagca tctaaagaac aaaatctgtc     2760

cagtcaaagt gattttcttc aagagccgtt acaggcagca attcccccag gcaagcaacc     2820

gtcttcacta gcttctccaa atcctcccat ggcaaagggc tctgaacagg gcttccagtc     2880

acctccagca agtagtagtt cagtaaccat taacacagca ccctttcaag ccatgcagac     2940

agtatttaac gttaatgcac ctctgcctcc acgaaaagaa caagaaataa aagaatcccc     3000

ttattcacct ggctacaatc aaagttttac cacagcaagt acacaaacac caccccagtg     3060

ccaactgcca tctatacatg tagaacaaac tgtccattct caagagactg cccctggcaa     3120

ccaccattct actttctga                                                  3139


<210> 3250
<211> 682
<212> DNA
<213> Homo sapiens

<400> 3250
ggaaacctgt tgagatcaca gagaatatac tgacggcata aaagggcaga accatagcag       60

ggtgcgcctc gcagtcacct ctgtgccctg ctggttgtct tcccagcgct gctgtagttg      120

ccttccatgg atctatagga gagcaagtcc tccaggagaa gaagtcctca ccagtgaacg      180

gagacctctc tgaactaagg ataccatggc cacgtcagcc ccactacgga gcctggaaga      240

ggaggtgacc tgctccatct gtcttgatta cctgcgggac cctgtgacca ttgactgtgg      300

ccacgtcttc tgccgcagct gcaccacaga cgtccgcccc atctcaggga gccgccccgt      360

ctgcccactc tgcaagaagc cttttaagaa ggagaacatc cgacccgtgt ggcaactgga      420

aaaaatcctg aaccacctga gtaccctaag gagggacaga gacaaaattc agggcttcca      480

ggcaaaggga gaagctgata tcctggccgc gctgaagaag ctccaggacc agaggcagta      540

cattgtggct gagtttgagc agggtcatca gttcctgagg gagcgggagg aacacctgct      600

ggaacagctg gcgaagctgg agcaggagct cacggagggc agggagaagt tcaagagccg      660

gggcgtcggg gagcttgccc gg                                               682


<210> 3251
<211> 1103
<212> DNA
<213> Homo sapiens

<400> 3251
attcacaagt gtgtgtaaag ggggtgtgga tgggacaact gcatctgcct cttgtgcatg       60

ccttggggca taaaatcttg ttattttaat ttgcatctgg gagaatgtct gagcaaggag      120

acctgaatca ggcaatagca gaggaaggag ggactgagca ggagacggcc actccagaga      180

acggcattgt taaatcagaa agtctggatg aagaggagaa actggaactg cagaggcggc      240

tggaggctca gaatcaagaa agaagaaaat ccaagtcagg agcaggaaaa ggtaaactga      300

ctcgcagcct tgctgtctgt gaggaatctt ctgccagacc aggaggtgaa agtcttcagg      360

atcagactct ctgaaaactg caaatggaaa ggaattcaaa agaatttaga ttaaaagtta      420

aataaaaagt aggcacagta gtgctgaatt ttcctcaaag gctctctttt gataaggctg      480

aaccaaatat aatcccaagt atcctctctc cttccttgtt ggagatgtct tacctctcag      540

ctccccaaaa tgcacttgcc tataagaaac acaattgctg gttcatatga aacttaggaa      600

atagtgaata aggtgcattt aactttggag aaatactttt atggctttgg tggagatttc      660

tcaatactgc aaaagttgtc cagaaatgaa tctgagctga tggtgacttt aagttaatat      720

tattaatata tcactgcata tttttaccct tatttttgct ccttacagca agattagtag      780

gttataaaaa tttaaattta aacaaaatta tttcatgaca aaatgggaaa cttcacatca      840

tacttatttt tgtttgcctt tcaggcatca tattagcttt tataaaaaat ggtcttgctg      900

ctgaaattgt acttatttta tcagaggctg ggtgcagtca agacaaaagt aaaatggttt      960

acctgagccc aggggaggga aaattgatta agatatcatt atttttgttt ggtttggttt     1020

tgcttttttc ctcttacttt aattgaaata ctctgaattc ccctcatgga aacagagagc     1080

attgagagca ctttctttaa aag                                             1103


<210> 3252
<211> 1356
<212> DNA
<213> Homo sapiens

<400> 3252
atggcggagg gcgcccagcc gcatcagccg cctcagctcg ggcccggcgc cgccgcccgg       60

ggcatgaagc gggagtcgga gctggagctg ccggtgcccg gagcgggagg agacggagcc      120

gatcccggcc tgagcaagcg gccgcgcact gaggaggcgg cggccgacgg tggcggcggg      180

atgcagaacg agcctctgac tccaggttat catggattcc cagcgcggga cagccagggt      240

aaccaggagc cgacaacaac tcctgacgca atggttcagc cttttactac catcccattt      300

ccaccacctc cgcagaatgg aattcccaca gagtatgggg tgccacacac tcaagactat      360

gccggccaga ccggtgagca taacctgaca ctctacggaa gtacgcaagc ccacggggag      420

cagagcagca actcacccag cacacaaaat ggatctctta cgcagacaga aggtggagca      480

cagacagacg gccagcagtc acagacacaa agtagtgaaa attcagagag taaatctacc      540

ccgaaacggc tgcatgtctc taatattcct ttccgcttcc gggaccctga cctccggcag      600

atgtttgggc agtttggcaa aatcctagat gtagaaataa tctttaatga acgtggctct      660

aagggattcg ggttcgtaac tttcgagaat agtgctgatg cagacagggc cagggagaaa      720

ttacacggca ccgtggtaga gggccgtaaa atcgaggtga ataatgctac agcacgtgta      780

atgaccaata agaagatggt cacaccatat gcaaatggtt ggaaattaag cccagtagtt      840

ggagctgtat atggtccgga gttatatgca gcatccagct ttcaagcaga tgtgtcccta      900

ggcaatgatg cagcagtgcc cctatcagga agagggggta tcaacactta cattccttta      960

atcagtctcc ctttagttcc tggcttccct taccctactg cagccaccac ggcagccgct     1020

ttcagaggag cccatttgag gggcagaggg cggacagtat atggtgcagt ccgagcggta     1080

cctccaacag ccatccccgc ctatccaggt gtggtttacc aggacggatt ttacggtgct     1140

gacctctatg gtggatatgc agcctacaga tatgcacagc ctgctactgc aaccgcagcc     1200

accgctgctg cagccgctgc agccgcttac agtgacggtt atggcagggt gtacacagcc     1260

gacccctacc atgcccttgc ccctgccgct agctatggag ttggcgctgt ggcgagttta     1320

taccgaggtg gctacagccg atttgccccc tactga                               1356


<210> 3253
<211> 859
<212> DNA
<213> Homo sapiens

<400> 3253
gccgcgggat gttctcccga aggagccacg gggatgtgaa gaagtccacc cagaaggtgc       60

tggacccgaa gaaggacgtg ctgacccgcc tgaagcacct gcgggcgctg ctggataatg      120

tggatgcaaa tgatcttaag cagttttttg agaccaacta ttctcagata tatttcatct      180

tctatgaaaa ttttatagca ctggaaaata gtttgaaatt aaaagggaat aataagtcac      240

aaagggagga gctggactcc atcctcttcc tttttgaaaa aatactgcag tttctacctg      300

aacgaatttt ctttcgatgg cattaccaga gtataggctc aactttaaag aagcttctac      360

acactggaaa ttctattaag ataagatgtg aaggaatcag gctgtttctt ctgtggcttc      420

aagcacttca gacaaactgt gcagaagagc aggttctgat ttttgcttgc ctggtgcctg      480

gtttcccagc agtcatgtca tccaggggcc cttgcacact ggagacactc atcaatccca      540

gccctagtgt agctgatgta aagatatatc cagaagaaat cactccactc ctaccagcca      600

tatcagggga gaagattgct gaggaccaaa cctgcttttt tcttcaaata ctgttgaagt      660

atatggttat tcaggctgcg agcttggagt ggaagaataa ggagaatcaa gatactggtt      720

ttaaatttct ttttacattg tttcgaaagt attatcttcc tcatttattt ccatcattta      780

ctaagttaac aaacatctac aaacctgtac ttgacatccc ccatttgaga ccaaagcctg      840

tgtacattac taccactcg                                                   859


<210> 3254
<211> 1150
<212> DNA
<213> Homo sapiens

<400> 3254
aagcgcaggc ggccaatgga acccgggagc ggtcgctgct gctgaggcgg cagtgtcggc       60

agtccaaccg cgactgcccg caccccctcc gcgggggtcc cccagagagt tgagtccacg      120

ctccatgaga atgctgaaca ccatccaaag cagcaaattg agattccttg atttggggaa      180

gaggtttggg aggaaccctt caataattgg catgggacaa gaggggaccc agtccaagtg      240

tatttgggac tcgcagtagg gaggaacaat tcagagagag cttggaagct cgaagtctgg      300

ctgtggccat gggagataca gtagtggagc ctgccccctt gaagccaact tctgagccca      360

cttctggccc accagggaat aatggggggt ccctgctaag tgtcatcacg gagggggtcg      420

gggaactatc agtgattgac cctgaggtgg cccagaaggc ctgccaggag gtgttggaga      480

aagtcaagct tttgcatgga ggcgtggcag tctctagcag aggcacccca ctggagttgg      540

tcaatgggga tggtgtggac agtgagatcc gttgcctaga tgatccacct gcccagatca      600

gggaggagga agatgagatg ggggccgctg tggcctcagg cacagccaaa ggagcaagaa      660

gacggcggca gaacaactca gctaaacagt cttggctgct gaggctgttt gagtcaaaac      720

tgtttgacat ctccatggcc atttcatacc tgtataactc caaggagcct ggagtacaag      780

cctacattgg caaccggctc ttctgctttc gcaacgagga cgtggacttc tatctgcccc      840

agttgcttaa catgtacatc cacatggatg aggatgtggg tgatgccatt aagccctaca      900

tagtccaccg ttgccgccag agcattaact tttccctcca gtgtgccctg ttgcttgggg      960

cctattcttc agacatgcac atttccactc aacgacactc ccgtgggacc aagctacgga     1020

agctgatcct ctcagatgag ctaaagccag ctcacaggaa gagggagctg ccctccttga     1080

gcccggcccc tgacacaggg ctgtctccct ccaaaaggac tcaccagcgc tctaagtcag     1140

atgccactgc                                                            1150


<210> 3255
<211> 906
<212> DNA
<213> Homo sapiens

<400> 3255
attttgggtt cgctttgcga ggggaaacga tcccagtgtc ggttgcggga tccgcctcct       60

ctcagtttgc ccctttagcc ctccaccttt cccttctcct ctctcgcatt tccgccagtc      120

ggcttacccg ctggccgcct cctgacaagc gggagggatc cgcggtggac ccagggaagc      180

ggaggagcct ggcggccacc ccctcttcct cacttccctg tactctcatc gctctcggcc      240

tccgacacga aaaggaagca aatgagctga tggaagatct gtttgaaact ttccaagatg      300

agatgggatt ctccaacatg gaagatgatg gcccagaaga ggaggagcgt gtggctgagc      360

ctcaagctaa ctttaacacc cctcaagctc tacggtttga ggaactactg gccaacctac      420

taaatgaaca acatcagata gcgaaggaac tatttgaaca gctgaagatg aagaaacctt      480

cagccaaaca gcagaaggag gtagagaagg ttaaacccca gtgtaaggaa gttcatcaga      540

ccctgattct ggacccagca caaaggaaga gactccagca gcagatgcag cagcatgttc      600

agctcttgac acaaatccac cttcttgcca cctgcaaccc caatctcaat ccggaggcca      660

gtagcaccag gatatgtctt aaagagctgg gaacctttgc tcaaagctcc atcgcccttc      720

accatcagta caaccccaag tttcagaccc tgttccaacc ctgtaacttg atgggagcta      780

tgcagctgat tgaagacttc agcacacatg tcagcattga ctgcagccct cataaaactg      840

tcaagaagac tgtttgttag ctttaggact gaagcatttt gaagggactg agtttcttaa      900

ccctct                                                                 906


<210> 3256
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 3256
gagtcaggaa tggagagaag ggtaatggtt ttacctctta ttgtggaaac ctgttgagat       60

cacagagaat atactgacgg cataaaaggg cagaaccata gcagggtgcg cgctgctgta      120

gttgccttcc atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg      180

aacggagacc tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg      240

aagaggaggt gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact      300

gtggccacgt cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc      360

ccgtctgccc actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac      420

tggccagcct ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag      480

aggtgacccg ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact      540

actactgtga ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca      600

ggccccacac ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga      660

accacctgag taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag      720

aagctgatat cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg      780

agtttgagca gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg      840

cgaagctgga gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg      900

agcttgcccg gctggccctg gtcatctccg aactggaggg caaggcgcag cagccagctg      960

cagagctcat gcaggacacg agagacttcc taaacaggta tccacggaag aagttctggg     1020

ttgggaaacc cattgctcga gtggttaaaa aaaagaccgg agaattctca gataaactcc     1080

tctctctgca acgaggcctg agggaattcc aggggaagct gctgagagac ttggaatata     1140

agacagtgag cgtcaccctg gacccacagt cggccagtgg gtacctgcag ctgtcagagg     1200

actggaagtg cgtgacctac accagcctgt acaagagtgc ctacctgcac ccccagcagt     1260

ttgactgtga gcctggggtg ctgggcagca agggcttcac ctggggcaag gtctactggg     1320

aagtggaagt ggagagggag ggctggtctg aggatgaaga agagggggat gaggaggaag     1380

agggagaaga ggaggaggag gaagaggagg ccggctatgg ggatggatat gacgactggg     1440

aaacggacga agatgaggaa tcgttgggcg atgaagagga agaagaggag gaggaagagg     1500

aggaagttct ggaaagctgc atggtggggg tggctagaga ctctgtgaag aggaagggag     1560

acctctccct gcggccagag gatggcgtgt gggcgctgcg cctctcctcc tccggcatct     1620

gggccaacac cagccccgag gctgagcttt tcccagcact gcggccccgg agagtgggca     1680

tcgccctgga ttatgaaggg ggcaccgtga ctttcaccaa cgcagagtca caggaactca     1740

tctacacctt cactgccacc ttcacccggc gcctggtccc cttcctgtgg ctcaagtggc     1800

caggaacacg cctcctgcta agaccctgag ccctgacatc tgcccccagc cccaaccctc     1860

agatgcttca cttctttgga attccaggac tctcaatggg gggacgggat gcctggccta     1920

agcacctgga gcaggggacc ccatatccac tggtagccac ctccccattg ctgtggcccc     1980

ctgaaatctc actcagtgct gttgctccat ctactgccct aatggggctc ttttcccacc     2040

tcctgctggt ttcccgaggg aacttctgac cctggagtcc atgagggctc ctttcctttt     2100

tgaccacgac cttggcccca gctctgcact ctctggaata agggcccgat gcagcatttt     2160

cttgcccagt gtggcaagac ctcagaaaaa ccagtcaatt acgcctaaga tcattttgct     2220

gtccttaaac cccccaggtt ccttcttgca caaatccact ctgctgccca ccttccctgg     2280

cattttaaac agacctaccc caccccaact cagagttaag catacatggc aatgctgaaa     2340

ataaacaaaa tccactgagg cttcccaggc catttaaagc ctggagtacc agcgcatatc     2400

atctcatggg gtccagagtg gagtccaggc ttctctgaaa ccagggctga gcatatttcc     2460

atagccaagg aggtgggact ccctggagct atctgtggtc ttagggaagg atccagacat     2520

acacggcttt ggggtacaag ctgtgatcac tgatcaataa attatctcta gattggtcct     2580

tgtgagggga gttttaagaa tccagaacat cttgctcttg atcagcacat ccaaaaacac     2640

caagacaaac atccagtgga gcagaacctc tcctgcctcg ggagttctga ccaggttccc     2700

cagcagggtg ttaagcctct gtctctggcc ctaccagcat ccaggttcca ctttcctagg     2760

agagagtgga gatgggaaga cagggaaagg aaggcagcag gaggccacaa gcccaccagg     2820

tcttcatgtc aagagaggga gtaacatgtc ttctcattgc ccacggaccc aacctctgtc     2880

caggtgcccc tcatcatcac agtttaacac aagctcccct gctccagcca aattgatctc     2940

ccagtcttgt ccttacccat tccaagtgct ctgccagccc ctgttcatcc aagttttaag     3000

tcctccaccc tgttctaaga gactgttcca acggctctgg gcctcagtgg tcacttgacc     3060

accattgtct cagagctgcc cactttgtgt gtgtcacatg ctgcctgagt cacacgtaca     3120

tcttatttct gcctctagtt ttgtaagctc ctggagggcg gataacatct tatactactc     3180

ttgtattctc atggcaccta gtgcagtgct gggcacagag taggtgctca ataaagactt     3240

gttgaatgaa                                                            3250


<210> 3257
<211> 1085
<212> DNA
<213> Homo sapiens

<400> 3257
gttactacag aaaaaactta tacaagcact agcaacaact ctatatctgg atcattgaag       60

cgcttggaag atactactgc acgatttaca aatgcaaatt tccaggaagt ctctgcacac      120

acctctagtg gaaaagatgt ttcagagact agagggtcag agggcaaagg gaagaaatct      180

tcagctcaca gctcaggtca aaggggaaga aagcctggtg gtggaagaaa tccaggaaca      240

actgtgtcag cagctagccc ttttcctcaa gcaggatata agcgggctca aacttctggc      300

atagaagaag aaactgtaaa ggaaaagaaa aggaaaggaa ataaacaaag taagcatggg      360

cctggcagac ccaaaggaaa caaaaatcaa gagaatgttt ctcatctctc agtttcttct      420

gcttcaccaa catcatctgt agcatcagct gcaggaagca taacaagctc tagtctgcag      480

aaatctccta cattgctcag gaatggaagt ttacagagcc tcagtgttgg ctcatctcca      540

gttggttcag aaatttccat gcagtatcgg catgatggag cttgcccaac aactacgttc      600

tcagagttgc tgaatgcaat acacaacgac agaggtgaca gttctacact aacaaagcaa      660

gaacttaaat tcataggtat ttataacagc aatgatgtag cagtatcgtt tccaaatgta      720

gtatctggct cgggatctag tactcctgtc tccagctctc acttacctca gcagtcttct      780

gggcatttgc aacaagtagg agcgctctct ccctcagctg tgtcatctgc agcccctgct      840

gttgctacaa ctcaggcaaa tactctatct ggatcttctc tcagtcaggc accatctcat      900

atgtatggca atagatcaaa ttcatcaatg gcagctctta tagctcagtc tgaaaacaat      960

caaacagatc aagatcttgg agacaatagc cgcaacctag ttggcagagg aagctcaccc     1020

cgaggaagtc tctcgccacg atcccctgta agcagcttac agattcgcta tgatcaacca     1080

ggcaa                                                                 1085


<210> 3258
<211> 560
<212> DNA
<213> Homo sapiens

<400> 3258
atattagata atggagaagc aaatggcaag gatggttacc ttggctacca agataaagaa       60

ccttgaaaag ggaagaagat gaaatcagct tcggatatca ggcaggcagc tgggtctgtg      120

ggtcagaggc ttaaggatgg ctgcagctcc tccaagttac tgttttgttg ccttccctcc      180

acgtgctaag gatggtctgg tggtatttgg gaaaaattca gcccggccca gagatgaagt      240

gcaagaggtt gtgtatttct cggctgctga tcacgaaccg gagagcaagg ttgagtgcac      300

ttacatttca atcgaccaag ttccaaggac ctatgccata atgataagca gacccgcctg      360

gctctgggga gcagaaatgg gagccaatga acatggagtg tgcatagcca atgaagccat      420

caacaccaga gagccagctg ccgagataga agccttgctg gggatggatc tggtcaggct      480

tggtttagaa agaggggaaa cagctaaaga agccttagat gtcattgtct ccttgttgga      540

agaacatgga caaggtggga                                                  560


<210> 3259
<211> 683
<212> DNA
<213> Homo sapiens

<400> 3259
ggcagctggc agcactgaaa gaaattcagg ctgaagttca ggaaaaagaa agtgatgctg       60

tgaagccaaa gaatcaggac attcaaggag ggaaagcagc ccctgctgaa gctctgggaa      120

tcccggatga gcactatcta gataatttgt gtattttttg tggggaaagg agtgaatcct      180

tcacagagga aggtctggat ctccactact ggaagcactg tctcatgctg acaagatgtg      240

accactgcaa acaggtggtc gagatatcca gtctgacgga gcacttgctg acggaatgtg      300

acaaaaaaga cgggtttgga aagtgttacc gttgcagtga ggctgttttc aaggaagagc      360

tgcccagaca cataaaacac aaggattgca accctgccaa accggagaag ctggcaaacc      420

ggtgtcccct gtgtcatgag aacttcagcc ctggagaaga ggcatggaaa gctcacctga      480

tgggcccagc cggctgcacg atgaacctgc gcaagacaca cattctgcag aaggccccgg      540

cactgcagcc aggtgaggga cagcgccgct gagcaggtgt agtctgcatc cctccatttt      600

gacttattca aaaaagcatc cccgtccagg gcaacatggc aagaccccat ccctttaaaa      660

gcaaaataaa gcatccaagc ctg                                              683


<210> 3260
<211> 1008
<212> DNA
<213> Homo sapiens

<400> 3260
aactccaggg ctagtgagct ggaccggaag taggtttcta cccgaccgca ttttacgtgg       60

tgctgcattt ccggtagcgg cggcgggaaa tcggctgtgg gagagaggct aggcctctga      120

ggaggcgaat ccggcgggta tcagagccat cagaaccgcc accatgacgg tgggcaagag      180

cagcaagatg ctgcagcata ttgattacag gatgaggtgc atcctgcagg acggccggat      240

cttcattggc accttcaagg cttttgacaa gcacatgaat ttgatcctct gtgactgtga      300

tgagttcaga aagatcaagc caaagaactc caaacaagca gaaagggaag agaagcgagt      360

cctcggtctg gtgctgctgc gaggggagaa tctggtctca atgacagtag agggacctcc      420

tcccaaagat actggtattg ctcgagttcc acttgctgga gctgccgggg gcccagggat      480

cggcagggct gctggcagag gaatcccagc tggggttccc atgccccagg ctcctgcagg      540

acttgctggg ccagtccgtg gggttggcgg gccatcccaa caggtgatga ccccacaagg      600

aagaggtact gttgcagccg ctgcagctgc tgccacagcc agtattgccg gggctccaac      660

ccagtaccca cctggccgtg ggggtcctcc cccacctatg ggccgaggag caccccctcc      720

aggcatgatg ggcccacctc ctggtatgag acctcctatg ggtcccccaa tggggatccc      780

ccctggaaga gggactccaa tgggcatgcc ccctccggga atgcggcctc ctccccctgg      840

gatgcgaggg ccccctcccc cgggaatgcg cccaccaagg ccctagactc atcttggccc      900

tcctcagctc cctgcctgtt tcccgtaagg ctgtacatag tccttttatc tccttgtggc      960

ctatgaaact ggtttataat aaactcttaa gagaacatta taattgca                  1008


<210> 3261
<211> 2065
<212> DNA
<213> Homo sapiens

<400> 3261
cagctcggtg ctgattatca caactgtttg gtgacctact tcactgacct gtgaggattc       60

cttcccttca ggtactggat tcttgatctt tctgcatcat caagaatgga aacagactgt      120

aatcccatgg agctaagcag tatgtcagga tttgaagaag gttcagagct gaacggtttt      180

gaaggaactg acatgaaaga catgaggctc gaagctgaag cagttgtaaa tgatgttctc      240

tttgctgtta acaacatgtt tgtctcgaaa agcctgcggt gtgcggatga tgtggcctat      300

atcaatgtgg aaacaaagga aagaaacaga tattgcctag aactcactga agcagggctc      360

aaggtggtag gctatgcttt tgaccaggta gatgatcatt tacagactcc ctaccatgaa      420

acagtctact ccttgttgga tacactcagc cccgcctacc gagaagcatt tggaaacgca      480

ctgcttcaaa gactggaagc tttgaaaaga gatggacagt catgactaca ctttttcctt      540

tcagaggggc tggtgctggt acagaatgtt gatataaagc ttaaaattct tgcatatggt      600

catagaaaat gcatctttgg ttttgtgttt ttatcacttg cttccaactt aggcttttgg      660

ctcagaagat tattgaataa tgatttgtct tagtttctgt ttcagtaagg gaattctgag      720

gccgttgcta tgataccatc attaagacat tcacatgtct tcatataata tctcttcatt      780

tcaaatccta atcactattt catactatta cagggctttg atgctgccag cactgtcttt      840

tacataggaa attctagatt tgcacagtaa tagaggaatt agaagtacct aactatacac      900

tttgattcag cctgctaaat caggggttca atactagctt ggacaaactt tgtagtaatt      960

aattgctacc agccttattg gaaacaaatt atcaactagt ttcccctgca caaattttga     1020

aattcactgc ttcacttaat ctatttatat tactaataat ggattaataa agatgaatta     1080

attatatatt acttaactag tattaaatga aaaacaggga ctgaaatagt tctgtattcc     1140

gtgtttgcaa cagccagcca actaagcaga ggataaaccg ttagcaaatg aatgtaataa     1200

ttactcattt ccaagatatc taagcacata agcaaataca ggaacagact tcattctttt     1260

tcttaacaaa aaagcatctt cagtgtgtga tttaaaagaa agaagattct ggtttcctag     1320

aaaacaatat tttggcctgt gttgattctt attctgaatg tgtgtttaca taatgtacag     1380

tatatattca gaaagtattt ttgcttcaac gtttactttc tatgatgtag tgctttggta     1440

ttcctacagc accccacctt ccccaacaga tgtacagtgt tctgtctcca ttcgaaatct     1500

acaatgtaat atgagtgcat tgtatgggtt tgaaaccaaa ggatgaatga agcattcaga     1560

gacttaatat ttgaaaaagg aatagtcagt attttatatt ttattacagg tactgatatt     1620

tataaattta ataaactgta ccatgctgct gcatgttttc aagtacatgt tgaacagtaa     1680

ggattgggga gttgtttttt aatggtcacc taaagcagct gctatagaaa tgttgaacta     1740

aaattttgca tctggtcata ccttcatgca tttatcattt gcagatattt ttccatcatt     1800

attaaaaaac aggaactttt aggctctgaa gatcatgtgg accagagcaa attaaagttc     1860

agtttgtgtc acaattcatt gccagacttc attggaatgc tttgtttgat gatgtatgtt     1920

cattctcagc tttattttca gatgcttaac tgggcaacga agtctaactt caggttgaac     1980

tttctcatgt ttaatctcag gctaaatgta aatgatattt gtaaagtttg aataaaattc     2040

tgtttactca ttttgagtta gtatg                                           2065


<210> 3262
<211> 1179
<212> DNA
<213> Homo sapiens

<400> 3262
attttggtct caggtgtgga ctcggcaaga accagcgcaa gagggaagca gagttatagc       60

taccccggcc gcggagccgg ctcactgcac tacccccgcc cccttctttc ctccagacgc      120

cgaagtcgcg ggcgctcatg gcgggcctgg aggtactgtt cgcatcggca gcgccggcca      180

tcacctgcag gcaggacgcg ctcgtctgct tcttgcattg ggaagtggtg acacacggtt      240

acttcggctt gggtgtcggt gaccagccgg gtcccaatga taagaagtca gaactgctgc      300

cagctgggtg gaacaacaat aaagacctgt atgtcctccg gtatgagtat aaggatgggt      360

ccagaaagct ccttgtgaaa gccatcaccg tggagagcag catgatcctc aatgtgctgg      420

aatatggctc acagcaagtg gcagacttga ccctgaactt ggatgattat atcgatgcag      480

aacacctggg tgacttccac aggtgtgatc ccctgggccc gtttgttgtc gggggagaag      540

acttagaccc ttttgggcct cggagaggtg gcatgattgt ggatcccctg agatctggct      600

tcccaagagc acttattgac ccttcctcag gcctcccgaa ccgacttcct ccaggcgctg      660

tgcccccagg agctcgcttt gacccctttg gacccattgg gaccagccca cccggcccga      720

ggcctgacag acgcgggcag tgatgagccc tgttctggag tggaaagagc acgatagagc      780

accaggctaa gaggcacgag atcaaggcgg tagtcacttc cgctctgcag ctagcatttc      840

aaccatatgt ggatcctttc atttctcagc tccctggatt ccttccccta aattaggacc      900

tattatttac ctgtaggtaa gcaagctact gtagctcttc tgaggtatct gccaggctgt      960

tttctgtagc ctcagattgc ctatctgctt agcctgagaa caggtagatg aaaactaaac     1020

tgatgcctag gcccagggtc agtctcagat ggaagctggg cctgggtggg gaggctagca     1080

tgcgtggctc cctgggtatt tctgtcagtc cccatggcaa gcagtgattt agtaaaacac     1140

cccagagtca gggaagccaa ccaccttgaa acctttaga                            1179


<210> 3263
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 3263
acggggcggg gacgagctgt cgcgctggtt gctcgtgcag gagcgggacc cggaacagac       60

cgccgtgaga gaggaggggt gccggccggg attcgcggcc cggagctcgg gaccggagtc      120

aggaatggag agaagggtaa tggttttacc tcttattgtg gaaacctgtt gagatcacag      180

agaatatact gacggcataa aagggcagaa ccatagcagg gtgcggttgc ttcattccag      240

cctcgcagtc acctctgtgc cctgctggtt gtcttcccag cgctgctgta gttgccttcc      300

atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg aacggagacc      360

tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg aagaggaggt      420

gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact gtggccacgt      480

cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc ccgtctgccc      540

actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac tggccagcct      600

ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag aggtgacccg      660

ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact actactgtga      720

ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca ggccccacac      780

ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga accacctgag      840

taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag aagctgatat      900

cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg agtttgagca      960

gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg cgaagctgga     1020

gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg agcttgcccg     1080

gctggccctg gtcatctccg aactggaggg caaggcgcag cagc                      1124


<210> 3264
<211> 4599
<212> DNA
<213> Homo sapiens

<400> 3264
actttgccag agcggccggg tccccattcc cattccttca aatccccttt ttcccggcag       60

ccgacctgta gacccaaggg agacaggttg aagctagaaa gagtcggggc agcagctctg      120

gtaggggagg gagcatccaa aacctctggc ttctgagcgc ctctcctgcc gcccatccac      180

aaagcccccc acagcctggc ggctgccctc gaccccgcaa aacaaaggac ttcagaggct      240

ggacctacag acccagatga gaaggcaaaa gcgtagggag gagcggcagg agatgggaag      300

ggcgggcccc gctcggagca gctgccgctt cctcccaaag tcccacgagg ggcctgagtc      360

acgggccacc gccctgggtc ggcgagctgg gggaagggat ctggacacct ggcgtgtccg      420

ggcgggaagc tggtgagggc ccctggggac agagcggagg accagtggtt ggggcgagaa      480

gagggcagtc ccgcagcgag tcccacgcgg ggtgggaggg atctaggccc cgccctctcc      540

tcggctccgc cctgcgcccc cttccctctc ctcattgtcc ttagacaaag cggtcgccgc      600

ccccgcccgg ccccctggtc tctgtctccg tccctcctcc tttgctgcct ctttccctcc      660

tcctctccct ccctcctccc ctccctccag tctccggatc tccctcggtc cctctctcct      720

cctcttcctc tctctggacg cccggctcct ccgcaccccc tcccccgggg gtcccgcggc      780

ctgtgagttg actgaggggc tcagacttgg ggagtgggtg tctcctcgcc cctgtccttg      840

ctcccgtccc tggcccggac cttggctgtc tcctctttgt gccgagattg tcagtctgtg      900

cggctacagc ggggtggaga cggccggctc tgtcacggct tcatgagagc ggggacgggg      960

cgcaggactt gcaggcgccg gggagaagag acatggagcc ggcccttggc actctggggt     1020

cgcgtggggc agtcggtggg ggaggcaggc ggtggtgaca ggacagggtg ggggtggacg     1080

ccagggttct gggaacgcgc tggcagccct gacgcccggg ttccgaaagt ctcgggggtg     1140

ggtatttccc ccgacccgcc tcgggggcgg agtgcggggc agaggggtgg gggctgggga     1200

gaggcgtggc ccgagcggtg ctggaagcgg agccgggacc tttggggccc gcgctgagac     1260

gcgcccggct gctgccgccg ccctcctttc ccctcttccc tggtttccct tctcctctag     1320

acctgttcgc tctccgcccc tccttgcctc cccaacaccc cctcaggtcc cgttgcctcc     1380

tggtcctttc agggattcct ggtccttcct tcccacacta gcctccctgg ggtatcgctg     1440

aggcagcctg gcctgcaccc aggttcccct cacccctgcc acatttctct cttctccctc     1500

acgccaactt tccttttcgc ccttctctct ctttctcaca tcctagagac ggtctttaat     1560

acgcattaac cctgtgctgc cacatctggc tcctgccctc attgcctcca atccggactc     1620

ttcctctcac atcaccccca ccacccccaa cttgggctca caacttctct tcactttttc     1680

catttcccca gttctctgcc ttccgtcttt ccctctgtcc tcatccttag cccctctgcc     1740

ctgctttgtg tcccacctct ccccctccac ttcctctcct cccaccctca gtctcacccc     1800

cgggctgtct cactctctgg agcctctcct tcctgttctc tgtccccagt gctccctacc     1860

ctcacctcaa gacgaccatg gccaccatcc cagactggaa gctacagctg ctagcccggc     1920

gccggcagga ggaggcgtcc gttcgaggcc gagagaaagc agaacgggag cgcctgtccc     1980

agatgccagc ctggaaacga gggctcctgg agcgccgccg ggccaagctt gggctgtccc     2040

ctggggagcc tagccctgtg ctagggactg tagaggctgg acctccagac ccggatgagt     2100

ctgcggtcct tctggaggcc atcgggccag tgcaccagaa ccgattcatc cggcaggagc     2160

ggcagcagca gcagcagcaa caacaacgga gtgaagagct gctagcagag agaaagcctg     2220

ggcctctgga ggcccgggag cggagaccca gccctgggga gatgcgggat cagagcccca     2280

agggaagaga gtcaagagaa gagagactaa gtccgaggga gaccagagag aggaggctgg     2340

ggataggggg agcccaagag ttgagcctga ggcctctgga ggctcgggac tggaggcaaa     2400

gcccaggaga ggtgggagac aggagctccc gactgtcaga ggcatggaaa tggaggctga     2460

gtcctggaga aactccagag cggagtctga gactagcaga gtctcgagag caaagcccca     2520

ggagaaaaga ggtggaaagt agactgagcc caggggaatc tgcctaccag aagttgggcc     2580

tgacagaggc ccataaatgg agacctgact ccagagagtc tcaggaacag agtttggtac     2640

aactggaggc aacagagtgg aggctgaggt caggagaaga aagacaagac tactcggaag     2700

aatgtgggag aaaagaagag tggccagttc caggggtagc tccaaaagag actgcagagc     2760

tgtccgagac cctgacaagg gaggcccaag gcaacagttc cgcaggagtg gaggcagcag     2820

agcagaggcc tgtggaagat ggcgagaggg gcatgaagcc aacagaaggg tggaaatgga     2880

ccctgaactc cgggaaggct cgagaatgga cacccaggga catagaggct caaactcaga     2940

aaccagaacc tccagagtca gcagagaagc ttctggaatc tcccggtgtg gaggctggag     3000

aaggggaggc tgagaaggag gaggcggggg ctcagggcag gcctctgaga gccctgcaga     3060

actgctgctc tgtgccctcc cccctcccac cagaggacgc tgggactgga ggcctgagac     3120

agcaggaaga ggaagcagtg gagctccagc ccccaccacc agcccctctg tctcccccac     3180

ccccagcccc aactgccccc caacctcctg gggatcccct catgagccgc ctgttctatg     3240

gggtgaaggc agggccaggg gtgggggccc cccgccgcag tggacacacc ttcaccgtca     3300

acccccggcg gtctgtgccc cctgcgaccc cagccacccc aacctctcca gccacagttg     3360

atgctgcagt cccgggggct gggaagaagc ggtacccaac tgccgaggag atcttggttc     3420

tggggggcta cctccgtctc agccgcagct gccttgccaa ggggtccccc gaaagacacc     3480

acaaacagct taagatctcc ttcagcgaga cagccctgga gaccacgtac caatacccct     3540

ccgagagttc ggtactggag gagctgggcc cggagcctga ggtccccagt gcccccaacc     3600

ctccagcagc ccaacccgac gacgaagagg atgaggaaga gctgctgctc ctgcagccag     3660

agctccaggg cgggctgcgc accaaggccc tgattgtgga tgagtcctgc cggcggtgac     3720

catcttccaa catagggata tacctccctc cttcttataa ctgaagatcc tggagcccgg     3780

aagattcagg gcagacagac cctgataatg agcctggcag ggaagggcaa ccaacatctt     3840

gtaacttgct ttccccaccc tgtttctggg ggcagagcca attgcccaat ttctacccta     3900

atccaaagtc cctggtgtgg gtggggttaa acgtgctggt gcatcctagg tcatccaaga     3960

gtgagcgcca agtcctgaga aggggcacag aactccctgg agggtggaga tggagcacct     4020

gccccccatg gcagggtaca ctctccccac agccttcctc cccaccatcc cgtggggact     4080

ctcgggattt aagcactcgt ctctctggga ggcccagacc ccactccatt tataggcaca     4140

tctccttcat ttcctaggtc actgcccctt tgtttacagc tcctgcctcc tcccttgacc     4200

acagcctggt ttacaaattc catcagctcc cagccccacc tgccaaagtc ccaggtttac     4260

aagccacgct tacttgctgt gtctgcgtgg aattctctcc tctgtcccct ccagtctcct     4320

cattggagtg acctgaaggt gtggcttcct ccactttttc tcagtattac tttgccttag     4380

ttttccccaa gagggaaggc tggaactctt aactctgtac cccttgatag ttatttaatt     4440

ctgtttctcc tagtggttca caattgaact gaattgagat ggtgtcgggt ggctaaggag     4500

acacctcacc tctccttccc cattgtgccg cctttatcaa ttgcctgttt tgttttgttt     4560

gttttttaac tttccataat aaaatggagt tctcttcaa                            4599


<210> 3265
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 3265
gagtcaggaa tggagagaag ggtaatggtg ttacctctta ttgtggaaac ctgttgagat       60

cacagagaat atactgacgg cataaaaggg cagaaccata gcagggtgcg cgctgctgta      120

gttgccttcc atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg      180

aacggagacc tctctgaact aagaatacca tggccacgtc agccccacta cggagcctgg      240

aagaggaggt gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact      300

gtggccacgt cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc      360

ccgtctgccc actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac      420

tggccagcct ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag      480

aggtgacccg ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact      540

actactgtga ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca      600

ggccccacac ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga      660

accacctgag taccctaagg agagacagag acaaaattca gggcttccag gcaaagggag      720

aagctgatat cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg      780

agtttgagca gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg      840

cgaagctgga gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg      900

agcttgcccg gctggccctg gtcatctccg aactggaggg caaggcgcag cagccagctg      960

cagagctcat gcaggacacg agagacttcc taaacaggta tccacggaag aagttctggg     1020

ttgggaaacc cattgctcga gtggttaaaa aaaagaccgg agaattctca gataaactcc     1080

tctctctgca acgaggcctg agggaattcc aggggaagct gctgagagac ttggaatata     1140

agacagtgag cgtcaccctg gacccacagt cggccagtgg gtacctgcag ctgtcagagg     1200

actggaagtg cgtgacctac accagcctgt acaagagtgc ctacctgcac ccccagcagt     1260

ttgactgtga gcctggggtg ctgggcagca agggcttcac ctggggcaag gtctactggg     1320

aagtggaagt ggagagggag ggctggtctg aggatgaaga agagggggat gaggaggaag     1380

agggagaaga ggaggaggag gaagaggagg ccggctatgg ggatggatat gacgactggg     1440

aaacggacga agatgaggaa tcgttgggcg atgaagagga agaagaggag gaggaagagg     1500

aggaagttct ggaaagctgc atggtggggg tggctagaga ctctgtgaag aggaagggag     1560

acctctccct gcggccagag gatggcgtgt gggcgctgcg cctctcctcc tccggcatct     1620

gggccaacac cagccccgag gctgagcttt tcccagcact gcggccccgg agagtgggca     1680

tcgccctgga ttatgaaggg ggcaccgtga ctttcaccaa cgcagagtca caggaactca     1740

tctacacctt cactgccacc ttcacccggc gcctggtccc cttcctgtgg ctcaagtggc     1800

caggaacacg cctcctgcta agaccctgag ccctgacatc tgcccccagc cccaaccctc     1860

agatgcttca cttctttgga attccaggac tctcaatggg gggacgggat gcctggccta     1920

agcacctgga gcaggggacc ccatatccac tggtagccac ctccccattg ctgtggcccc     1980

ctgaaatctc actcagtgct gttgctccat ctactgccct aatggggctc ttttcccacc     2040

tcctgctggt ttcccgaggg aacttctgac cctggagtcc atgagggctc ctttcctttt     2100

tgaccacgac cttggcccta gctctgcact ctctggaata agggcccgat gcagcatttt     2160

cttgcccagt gtggcaagac ctcagaaaaa ccagtcaatt acgcctaaga tcattttgct     2220

gtccttaaac cccccaggtt ccttcttgca caaatccact ctgctgccca ccttccctgg     2280

cattttaaac agacctaccc caccccaact cagagttaag catacatggc aatgctgaaa     2340

ataaacaaaa tccactgagg cttcccaggc catttaaagc ctggagtacc agcgcatatc     2400

atctcatggg gtccagagtg gagtccaggc ttctctgaaa ccagggctga gcatatttcc     2460

atagccaagg aggtgggact ccctggagct atctgtggtc ttagggaagg atccagacat     2520

acacggcttt ggggtacaag ctgtgatcac tgatcaataa attatctcta gattggtcct     2580

tgtgagggga gttttaagaa tccagaacat cttgctcttg atcagcacat ccaaaaacac     2640

caagacaaac atccagtgga gcagaacctc tcctgcctcg ggagttctga ccgggttccc     2700

cagcagggtg ttaagcctct gtctctggcc ctaccagcat ccaggttcca ctttcctagg     2760

agagagtgga gatgggaaga cagggaaagg aaggcagcag gaggccacaa gcccaccagg     2820

tcttcatgtc aagagaggga gtaacatgtc ttctcattgc ccacggaccc aacctctgtc     2880

caggtgcccc tcatcatcac agtttaacac aagctcccct gctccagcca aattgatctc     2940

ccagtcttgt ccttacccat tccaagtgct ctgccagccc ctgttcatcc aagttttaag     3000

tcctccaccc tgttataaga gactgttcca acggctctgg gcctcagtgg tcacttgacc     3060

accattgtct cagagctgcc cactttgtgt gtgtcacatg ctgcctgagt cacatgtaca     3120

tcttatttct gcctctagtt ttgtaagctc ctggagggcg gataacatct tatactactc     3180

ttgtattctc atggcaccta gtgcagtgct gggcacagag taggtgctca ataaagactt     3240

gttgaatgaa                                                            3250


<210> 3266
<211> 2020
<212> DNA
<213> Homo sapiens

<400> 3266
aatggggacc tggaacctgg gcttactaga gtgccgcgcg tagggctcca ggtcgctggc       60

ttctgcgctt ccttcctctc caaagttgag tatctcctat ctgtgtcctc gtacatactg      120

ccgcctgagg tgccatggcc cccaagccgg gggccgagtg gagcacagcc ctgtcccatc      180

tggtgctggg agtggtgtct ctgcacgcag ccgtgagcac agccgaggca agtcgagggg      240

ctgctgctgg cttcctgctc caggtcttgg ctgccaccac cacgctggcc ccagggctga      300

gcacacacga agactgcctt gctggagcct gggtggccac cgtcatcggc cttccccttc      360

tggccttcga tttccactgg tgtactaatg gtcacttgat gtgcgctggc tgttttatcc      420

acctactagc agatgcccgg ctgaaggagg agcaggccac gtgccccaat tgtcgttgtg      480

agatcagtaa gagcctctgc tgccggaacc tggccgtgga gaaagccgtg agcgagctgc      540

cttcagagtg tggcttctgc ctgcgccagt ttccccgctc cctcctggag aggcaccaga      600

aagaggaatg ccaggacagg gtaacccagt gcaagtacaa acgcatcggc tgcccatggc      660

acggcccctt ccatgagctg acggtgcacg aggctgcgtg cgcccacccg accaagacag      720

gcagtgagct gatggagatc ctggatggga tggaccagag ccaccgcaag gagatgcagc      780

tgtacaacag catcttcagc ctgctcagct tcgagaagat tggctacaca gaggtccagt      840

tccggccgta ccgcacagac gacttcatca cgcgcctgta ctatgagacg cccaggttca      900

cagtgctgaa ccagacgtgg gtcctgaagg ctcgagtcaa cgactcggag cgtaacccca      960

acctgtcctg caagcgtacg ctctccttcc agctcctcct caagagcaag gtcacggcac     1020

cgctggagtg ctccttcctg ctgctcaagg gcccctacga cgacgtgagg atcagccccg     1080

tcatctacca ctttgtcttc accaacgaga gcaacgagac ggactacgtg ccactgccca     1140

tcattgactc cgtggagtgc aacaagctgc tggctgccaa gaacatcaac ctgcggctct     1200

tcctgttcca gatacagaag tagggcgggg cctcaggatg tccgaggagc ccacgggcgg     1260

catcccagca ccgctgccct gtccacctgg ctggcagctg cttcacagga ctatctgatc     1320

actttagcaa aggaggagaa caaacgaagc caacacaggg caagtctgca tgcgtgcgcg     1380

acggggcccc cgcctccggc tcaccccccc gacccctgcc tcccctcctt ccgagggccg     1440

ccagaggctg ggctgacccg aagaggagac ggtgcaccag gcgccccgag gctcagagac     1500

ggtggcagca aggaggccga gaggcacagc gaccctgccc cagcccttct gtgcagtcag     1560

gcggcggtgc tgctccatcc ctgcgggttc cggcggggcg cgggggcctt gctgacatca     1620

gacgggatat ccgaatatct gatagcaatt aaaaggcagc cttgtttcgt actttctgtt     1680

ttgttcgagg ggaaggcatg gctgtgaatg gacagcgtgg gggctttggt ttggcctggg     1740

ggtcagagcc tgccccgccc ccatctgtgt gcccgcacac gtcccccgag gaaagactca     1800

gagacactgc ctccccctac actctgtcat ggggtcttga gactgaggct tgggcaggaa     1860

gatccaggta gggtcggggc tgccctggcc aaccggccgc tcccagggag acaggactca     1920

gccaccaggg ctcagcaggc attttccgaa agcagggtga aattgtctct tcccaggaaa     1980

aagattaaac tccttgcagg ctcttggata agttacacaa                           2020


<210> 3267
<211> 540
<212> DNA
<213> Homo sapiens

<400> 3267
tggctgcctt ctcctgagag tcggagccac agccagagcc ctgcccaggc cgagccggag       60

ctgcagcccg agcgcggtgg tgccctcagc cccgtcctct tgtcctcctc agcctcgaaa      120

cttccaattg aagacactga gctgaaccat tccgcccgcc cgcccgcccg agggcactcc      180

agatctgccg gaggcgctgg gcaatgaccc cgggactcca ggccagaggg gtctgaagct      240

gtttgggaaa gcagcgggac tccttgggaa gatggccatg gccccaagcc cttccctggt      300

gcaggtgtac accagccccg cggctgtggc cgtgtgggaa tggcaggacg ggctgggcac      360

ctggcacccc tacagtgcca ccgtctgcag cttcatcgag cagcagtttg tccagcagaa      420

gggccaacgt tttgggcttg ggagcctggc ccacagcatc cccttgggcc aggcagaccc      480

ctcgctggcc ccttacatta ttgacctccc cagctggacc cagttccgcc aggacaccgg      540


<210> 3268
<211> 2926
<212> DNA
<213> Homo sapiens

<400> 3268
aggtgtcacc acagtgatgg cagtggagga cagcacgctg caagtagtgg tacgggtgcg       60

gccccccacc cctcgggagc tggacagtca gcggcggcca gtggttcagg tggtggacga      120

gcgggtgctg gtgtttaacc ctgaggagcc cgatggaggg ttccctggcc tgaaatgggg      180

tggcacccat gatggcccca agaagaaggg caaagacctg acgtttgtct ttgaccgggt      240

ctttggcgag gcggccaccc aacaggacgt gttccagcac accacgcaca gcgtcctgga      300

cagcttcctc cagggctaca actgctcagt gtttgcctac ggggccaccg gggctgggaa      360

gacacacacc atgctgggaa gggaggggga ccccggcatc atgtacctga ccaccgtgga      420

actgtacagg cgcctggagg cccgccagca ggagaagcac ttcgaggtgc tcatcagcta      480

ccaggaggtg tataatgaac agatccatga cctcctggag cccaaggggc cccttgccat      540

ccgcgaggac cccgacaagg gggtggtggt gcaaggactt tctttccacc agccagcctc      600

agccgagcag ctgctggaga tactgaccag ggggaaccgt aaccgcacgc agcaccccac      660

tgatgccaac gcgacttcct cccgctccca tgccatcttc cagatctttg tgaagcagca      720

ggaccgggtt ccaggactga cccaggctgt ccaggtggcc aagatgagcc tgattgacct      780

ggctggctca gagcgggcat ccagcaccca tgcgaagggg gagcggctgc gggagggggc      840

caacatcaac cgctctctgc tggcgctcat caacgtcctc aatgccttgg ccgatgcaaa      900

gggccgcaag acccatgtgc cctaccggga cagcaaactg acccgcctgc tcaaagactc      960

cctcgggggc aactgccgca cagtgatgat cgctgccatc agcccctcca gcctgaccta     1020

cgaggacacg tacaacaccc tcaaatatgc cgaccgggcc aaggagatca ggctctcgct     1080

gaagagcaat gtgaccagcc tggactgtca catcagccag tatgctacca tctgccaaca     1140

gctccaggct gaggtagccg ctctgaggaa gaagctccaa gtgtatgagg ggggaggcca     1200

gcccccacca caggacctcc caggatctcc caagtcggga ccaccaccag aacaccttcc     1260

cagctccccc ttgccacccc accctcccag ccagccctgc accccagagc tccctgcagg     1320

gcctagagcc cttcaagagg agagtctggg gatggaggcc caggtggaga gggccatgga     1380

agggaactct tcagaccagg agcagtcccc agaggatgag gatgaaggcc cagctgagga     1440

ggttccaacc cagatgccag agcagaaccc cacacatgca ctgccagagt cccctcgcct     1500

gaccctgcag cccaagccag tcgtgggcca cttctcagca cgggaactgg atggggaccg     1560

ttctaagcag ttggccctaa aggtgctgtg cgttgcccag cggcagtact ccctgctcca     1620

agcagccaac ctcctgacgc ccgacatgat cacagagttt gagaccctac agcagctggt     1680

gcaagaggaa aaaattgagc ctggggcaga ggccttgagg acttcaggcc tggccagggg     1740

ggcacctctg gctcaggagc tgtgttcaga gtcaatccct gtgccgtctc ctctctgccc     1800

agagcctcca ggatacactg gccctgtgac ccggactatg gcgaggcgac tgagtggccc     1860

cctgcacacc ctgggaatcc cgcctggacc caactgcacc ccagcccagg ggtcccgatg     1920

gcccatggag aagaagagga ggagaccaag cgccttggag gcagacagtc ccatggcccc     1980

aaagcggggc accaagcgcc agcgccagtc cttcctgccc tgcctaagga gagggtctct     2040

gcctgacacc caaccttcac aggggcccag cacccccaaa ggagaaaggg cctcctcccc     2100

ctgccattcc cctcgcgttt gcccagccac agtcatcaaa agccgggtgc ccctgggccc     2160

ttccgccatg cagaactgct ccaccccgct ggctctgccc actcgagacc tcaatgccac     2220

ctttgatctc tctgaggagc ctccctcaaa gcccagtttc catgaatgca ttggctggga     2280

caaaataccc caggagctga gcaggctgga ccagcccttc atccccaggg cacctgtgcc     2340

cctgttcacc atgaagggcc ccaagccaac atcttccctc cctgggacct ctgcctgcaa     2400

gaagaagcgc gttgcgagtt cctcagtctc ccatggccgc agccgcatcg cccgcctccc     2460

cagcagcact ttgaagaggc cagctgggcc ccttgtactc ccaggtgact ggcactaggg     2520

acagggatag cctgggccat ggaggccgat gaagacaaga aggaggaggg gacggggagc     2580

tgagacccag aagaaaggag ggcctagggt attgccaagc atctcaggga tgctgctgat     2640

gagacaggtg ggaggtgggc tggaggacgg ggacagagcg tcactttcct tcctcgctgc     2700

actccccgcc acccatccaa ctggcctgca gagctgccct tgagtcccct gtgccctagc     2760

aaccggagga atggaaagga cctcatcagg gtggggagag cactctcagc agggaacggc     2820

gtcaccaagg tgtcctgacc gccagaatgt cctgaccacc aaggtgtcct aacctaccgg     2880

cccctctgct ggatacccct cttggacctg tagccacctg caccag                    2926


<210> 3269
<211> 2853
<212> DNA
<213> Homo sapiens

<400> 3269
cctccctcca gtctccggat ctccctcggt ccctctctcc tcctcttcct ctctctggac       60

gcccggctcc tccgcacccc ctcccccggg ggtcccgcgg ccttgctccc taccctcacc      120

tcaagacgac catggccacc atcccagact ggaagctaca gctgctagcc cggcgccggc      180

aggaggaggc gtccgttcga ggccgagaga aagcagaacg ggagcgcctg tcccagatgc      240

cagcctggaa acgagggctc ctggagcgcc gccgggccaa gcttgggctg tcccctgggg      300

agcctagccc tgtgctaggg actgtagagg ctggacctcc agacccggat gagtctgcgg      360

tccttctgga ggccatcggg ccagtgcacc agaaccgatt catccggcag gagcggcagc      420

agcagcagca gcaacaacaa cggagtgaag agctgctagc agagagaaag cctgggcctc      480

tggaggcccg ggagcggaga cccagccctg gggagatgcg ggatcagagc cccaagggaa      540

gagagtcaag agaagagaga ctaagtccga gggagaccag agagaggagg ctggggatag      600

ggggagccca agagttgagc ctgaggcctc tggaggctcg ggactggagg caaagcccag      660

gagaggtggg agacaggagc tcccgactgt cagaggcatg gaaatggagg ctgagtcctg      720

gagaaactcc agagcggagt ctgagactag cagagtctcg agagcaaagc cccaggagaa      780

aagaggtgga aagtagactg agcccagggg aatctgccta ccagaagttg ggcctgacag      840

aggcccataa atggagacct gactccagag agtctcagga acagagtttg gtacaactgg      900

aggcaacaga gtggaggctg aggtcaggag aagaaagaca agactactcg gaagaatgtg      960

ggagaaaaga agagtggcca gttccagggg tagctccaaa agagactgca gagctgtccg     1020

agaccctgac aagggaggcc caaggcaaca gttccgcagg agtggaggca gcagagcaga     1080

ggcctgtgga agatggcgag aggggcatga agccaacaga agggtggaaa tggaccctga     1140

actccgggaa ggctcgagaa tggacaccca gggacataga ggctcaaact cagaaaccag     1200

aacctccaga gtcagcagag aagcttctgg aatctcccgg tgtggaggct ggagaagggg     1260

aggctgagaa ggaggaggcg ggggctcagg gcaggcctct gagagccctg cagaactgct     1320

gctctgtgcc ctcccccctc ccaccagagg acgctgggac tggaggcctg agacagcagg     1380

aagaggaagc agtggagctc cagcccccac caccagcccc tctgtctccc ccacccccag     1440

ccccaactgc cccccaacct cctggggatc ccctcatgag ccgcctgttc tatggggtga     1500

aggcagggcc aggggtgggg gccccccgcc gcagtggaca caccttcacc gtcaaccccc     1560

ggcggtctgt gccccctgcg accccagcca ccccaacctc tccagccaca gttgatgctg     1620

cagtcccggg ggctgggaag aagcggtacc caactgccga ggagatcttg gttctggggg     1680

gctacctccg tctcagccgc agctgccttg ccaaggggtc ccccgaaaga caccacaaac     1740

agcttaagat ctccttcagc gagacagccc tggagaccac gtaccaatac ccctccgaga     1800

gttcggtact ggaggagctg ggcccggagc ctgaggtccc cagtgccccc aaccctccag     1860

cagcccaacc cgacgacgaa gaggatgagg aagagctgct gctcctgcag ccagagctcc     1920

agggcgggct gcgcaccaag gccctgattg tggatgagtc ctgccggcgg tgaccatctt     1980

ccaacatagg gatatacctc cctccttctt ataactgaag atcctggagc ccggaagatt     2040

cagggcagac agaccctgat aatgagcctg gcagggaagg gcaaccaaca tcttgtaact     2100

tgctttcccc accctgtttc tgggggcaga gccaattgcc caatttctac cctaatccaa     2160

agtccctggt gtgggtgggg ttaaacgtgc tggtgcatcc taggtcatcc aagagtgagc     2220

gccaagtcct gagaaggggc acagaactcc ctggagggtg gagatggagc acctgccccc     2280

catggcaggg tacactctcc ccacagcctt cctccccacc atcccgtggg gactctcggg     2340

atttaagcac tcgtctctct gggaggccca gaccccactc catttatagg cacatctcct     2400

tcatttccta ggtcactgcc cctttgttta cagctcctgc ctcctccctt gaccacagcc     2460

tggtttacaa attccatcag ctcccagccc cacctgccaa agtcccaggt ttacaagcca     2520

cgcttacttg ctgtgtctgc gtggaattct ctcctctgtc ccctccagtc tcctcattgg     2580

agtgacctga aggtgtggct tcctccactt tttctcagta ttactttgcc ttagttttcc     2640

ccaagaggga aggctggaac tcttaactct gtaccccttg atagttattt aattctgttt     2700

ctcctagtgg ttcacaattg aactgaattg agatggtgtc gggtggctaa ggagacacct     2760

cacctctcct tccccattgt gccgccttta tcaattgcct gttttgtttt gtttgttttt     2820

taactttcca taataaaatg gagttctctt caa                                  2853


<210> 3270
<211> 1270
<212> DNA
<213> Homo sapiens

<400> 3270
gactgctgga ggcggccaca gcgccatgtt ggatgctctg ctcgttgagt gaagaaaatc       60

caccggcatc gcctgagccc cgctaccgag aagggcgccg cttcctccgg ggagggggat      120

aaagatcccc cgccgccggc ccatgaggat attgccgtga aaggcacagc gactgcagca      180

ggaaccggac ccggcaccgg agcggcggcg gcggcggcag cagcggtacc gcctcctcac      240

ccggcggcgg cagcagcggc ggcggcggcg gcggcggcgg cggcggcggc agcggtcccc      300

cctcctcacc cgaacatcag ggccctccag actcaggcgc cccaacaaat tcctagagga      360

cctgtgcaac aacctcttga ggatcgaatc ttcactcccg ctgtctcagc agtctacagc      420

acggtaacac aagtggcaag acagccggga acccctaccc catcccctta ttcagcacat      480

gaaataaaca aggggcatcc aaatcttgcg gcaacgcccc cgggacatgc atcgtcccct      540

ggactctctc aaacccctta tccctctgga cagaatgcag gtccaaccac gctggtatac      600

cctcaaaccc ctcagacaat gaattcacaa cctcaaaccc gttctccgtt tttccagagg      660

cctcaaatac agcctcctag agctaccatc ccgaacagca gtccttccat tcgtcctggt      720

gcacagacac ccactgcagt gtaccaggct aatcagcaca tcatgatggt taaccatctg      780

cccatgccgt acccagtgcc ccaggggcct cagtactgta taccacagta ccgtcatagt      840

ggccctcctt atgttgggcc cccccaacaa tatccagttc aaccaccggg gccaggtcct      900

ttttatcctg gaccaggacc tggggacttc cccaatgctt atggaacgcc tttttaccca      960

agtcagccgg tgtatcagtc agcacctatc atagtgccta cgcagcaaca gccgcctcca     1020

gccaagagag agaaaaaaac tataagaatt cgggatccaa accagggagg taaagacata     1080

acagaggaga ttatgtctgg aggtggcagc agaaatccta ctccacccat aggaagaccc     1140

acgtccacac ctactcctcc tcagcagctg cccagccagg tccccgagca cagccctgtg     1200

gtttatggga ctgtggagag cgctcatctt gctgccagca cccctgtcac tgcagctagc     1260

gaccagaagc                                                            1270


<210> 3271
<211> 3473
<212> DNA
<213> Homo sapiens

<400> 3271
agcacttgaa gttcaggcag cgagagttga catggggcca gggctgcgcc cctggggcgg       60

gttgaagaca gggtgagtct cttgatattc aggaaatcat cgcgcaccca gtcaccagcg      120

ttcgggagcc tgtcgcagcg ggaccgacgg aatccggagc aggcgacagg gcgcagaagc      180

gggatgtact tctgttgggg cgccgactcc agggagctgc agcgccggag gacggcgggc      240

agccccgggg ctgagctact gcaggcggcc agcggggagc gccactctct gctgctgctg      300

accaaccaca gggtcctctc gtgcggagac aacagcaggg gtcagctggg ccgcaggggc      360

gcgcagcgcg gggagctgcc agaaccaatt caggcattgg aaaccctaat tgttgatctc      420

gtgagctgcg ggaaggagca ctccctggct gtgtgccaca aaggaagggt cttcgcatgg      480

ggagctggtt ctgaagggca gctggggatt ggagaattca aggaaataag tttcacacct      540

aagaaaataa tgactctgaa tgatataaaa ataatacaag tttcctgtgg acactaccac      600

tccctggcat tatcaaaaga tagccaagtg ttttcgtggg gaaagaacag ccatgggcag      660

ctgggcttgg ggaaggagtt cccctcccaa gccagcccgc agagggtgag gtccctggag      720

gggatcccac tggctcaggt ggctgccgga ggggctcaca gctttgccct gtctctctgt      780

gggacttcgt ttggctgggg aagtaacagt gccgggcagc tggccctcag tgggcgtaat      840

gtcccagtgc aaagcaacaa gcctctctca gtcggtgcac tgaagaatct aggtgtggtt      900

tatatcagct gtggtgatgc acacactgcg gtgcttaccc aggacgggaa agtgttcaca      960

tttggagaca atcgctctgg acagctggga tacagcccca ctcctgagaa gagaggtcca     1020

caacttgtgg aaagaattga tggcctagtt tcgcagatag attgtggaag acttcgtgga     1080

tgttcaagtc aaacacattt ttgctggaac atatgccaac tttgtgacaa ctcatcagtg     1140

aaattagaat gatattttca tctcctgctt gtctgactgc aagtttttta aagaaaagag     1200

gaactggaga aacgacttcc attgatgtgg acttagaaat ggcaagagat accttcaaga     1260

agttaacaaa aaaggaatgg atttcttcca tgataactac gtgtctcgag gatgatctgc     1320

tcagagctct tccatgccat tctccacacc aagaagcttt atcagttttc ctcctgctcc     1380

cagaatgtcc tgtgatgcat gattctaaga actggaagaa cctggtggtt ccatttgcaa     1440

aggctgtgtg tgaaatgagt aaacaatctt tgcaagtcct aataaacaaa gctaactgtc     1500

gactaccaga aaatactttc aacataaatg aactctccaa cttattaaac ttttatatag     1560

atagaggaag acagctcttt cgggataacc acctgatacc tgcagaaacc cccagtcctg     1620

ttattttcag tgattttcca tttatcttta attcgctatc caaaattaaa ttattgcaag     1680

ctgattcaca tataaagatg cagatgtcag aaaagaaagc atacatgctt atgcatgaaa     1740

caattctgca aaaaaaggat gaatttcctc catcacccag atttatactt agagtcagac     1800

gaagtcgcct ggttaaagat gctctgcgtc aattaagtca agctgaagct actgacttct     1860

gcaaagtatt agtggttgaa tttattaatg aaatttgtcc tgagtctgga ggggttagtt     1920

cagagttctt ccactgtatg tttgaagaga tgaccaagcc agaatatgga atgttcatgt     1980

atcctgaaat gggttcctgc atgtggtttc ctgccaagcc taaacctgag aagaaaagat     2040

atttcctctt tggaatgctg tgtggactct ccttattcaa tttaaatgtt gctaaccttc     2100

ctttcccact ggctctgtat aaaaaacttc tggaccaaaa gccatcattg gaagatttaa     2160

aagaactcag tcctcggttg gggaagagtt tgcaagaagt tctagatgat gctgctgatg     2220

acattggaga tgcgctctgc atacgctttt ctatacactg ggaccaaaat gatgttgact     2280

taattccaaa tgggatctcc atacctgtgg accaaaccaa caagagagac tatgtttcta     2340

agtatattga ttacattttc aacgtctctg taaaagcagt ttatgaggaa tttcagagag     2400

gattttatag agtctgtgag aaggagatac ttagacattt ctaccctgaa gaactaatga     2460

cagcaatcat tggaaatact gattatgact ggaaacagtt tgaacagaat tcaaagtatg     2520

agcaaggata ccaaaaatca catcctacta tacagttgtt ttggaaggct ttccacaaac     2580

taaccttgga tgaaaagaaa aaattcctct ttttccttac aggacgtgat aggctgcatg     2640

caagaggcat acagaaaatg gaaatagtat ttcgctgtcc tgaaactttc agtgaaagag     2700

atcacccaac atcaataact tgtcataata ttctctccct ccctaagtat tctacaatgg     2760

aaagaatgga ggaagcactt caagtagcca tcaacaacaa cagaggattt gtctcaccca     2820

tgctcacaca gtcataatca cctctgagag actcagggtg ggctttctca cacttggatc     2880

cttctgttct tccttacacc taaataatac aagagattaa tgaatagtgg ttagaagtag     2940

ttgagggaga gattggggga atggggagat gatgatgatg gtcaaagggt gcaaaatctc     3000

acacaagact gaggcaggag aatagggtac agagataggg atctaaggat gacttggaca     3060

cactccctgg cactgaagag tctgaacact ggcctgtgat tggtccattc caggaccttc     3120

atttgcataa ggtatcaaac cacatcagcc tctgattggc catgggccag acctgcactc     3180

tggccaatga ttggttcatt ccaggacatt catttgcata aggagtcaaa ccacaccagt     3240

cttggattgg ctgtgagcca attcacctca gtctctaatt ggctgtgagt cagtctttca     3300

tttacatagg gtgtaaccat caagaaacct ctacagggta cttaagcccc agaagatttt     3360

gctaccaggg ctcttgagcc acttgctcta gcccactccc accctgtgga atgtactttc     3420

acttttgctg cttcactgcc ttgtgctcca ataaatccac tccttcacca ccc            3473


<210> 3272
<211> 2373
<212> DNA
<213> Homo sapiens

<400> 3272
acctgctggg agctggagga ggcgcggagc gaagccggcc ctgccagcca cgcggagaag       60

cagaggcagg tgagcgcgat gcagccggcg ccgggtctgg ggctcgggga ctcctccctg      120

caccgctacc tggacggcga cttctggagc ctcaagaacg agctgcgcgg actcctcggc      180

ggcgcccgct cttccggcaa aggtatgatt taagcttgga tgaaatgaga gctttgacag      240

ttcagagagt gaagtttgcc atggacctgc ctctgttaaa acgtgcaggt caggatctgg      300

cagagaaaac aaagaatttt gtcagccgaa gccttgtcat aggagaagtc ctctccatgg      360

cggacatggc cacaggagtg aagtgcggaa taatttattg gctatttggt ggtgctatca      420

ggaatctcgg aagccctgaa catgttacta agtggtttca gccactccag gagcagaaat      480

acactgggat gtttgcaatg accgagaggg gccatgggag caacgcgaga gggatccaga      540

ccgaagccac ctttgacctc tctgcccagg agtttgtaat tgacacgccg tgtgaaaatg      600

cggagaagat gtatattgga aatgccatgt acgggaatta tgcagctgtc tttgcccagc      660

tcatcataga tggaagatct caagggcccc actgtttcat cgttcctgtc cgggatgaaa      720

acggaagctt gtacccagga gtcacagcta ttgatatgat gtacaaggag ggtctgcatg      780

gtgtggacaa tgggatatta atatttgaca aggttcggat acccagggag aacctgctgg      840

ataagtttgg ttccgtggct ccagatggac agtaccattc gcctattagg aacaagagtg      900

caagattcaa tgccatgctg gcagcactga ccccttcgag attagctgtg gctttccaag      960

ctatgggtgc catgaagctt gggttgacga tagccattcg ctatagccac agccggaggc     1020

agtttgggcc caaaaccaag gaagaggtga agatcattga gcaccaaaca cagaccctgc     1080

ggctgatgcc ccacctggcc acagccttgg ccctgacctt cgtcagcagg tatgctgggg     1140

ccctcctgga tgaggatgtc ttccagggaa aggagctggt caacagtcgc tcgctgcagg     1200

ctctggtggc ggggctgaag gcctacagca cctgggagaa catccgctgc ctgcaggact     1260

gccgcgagtg cactggaggc atggttgtgg ggcgggaact gctggcccaa tacaccaaac     1320

agtatgaaga aaaaccactc tttggcctgc tccaaaactg ggctgaatct gtgggggaca     1380

agctgagaac cagtttcctg gcatttaaca tggacacagt tgatgatctc gcctttctgt     1440

tgaaagcagt gaaatttcgt gaaagggttc ttcagcgggg tttggtggcc agaatttatt     1500

ataaggtaaa gaccaagaag gaggattttt tccatgcctg gaactcgtgt ctgcaccacg     1560

tggcttctct gtccctggca cacactcacc gagttacctt agagcagttc tccctagcag     1620

tgaagagctg tcctgaccaa gaggaccaga ctttgttaat gaagttttgt ctgttgtatg     1680

gaaccaagct ggtgtttcag gagcgggcct ggtatttaga acataaatac ttgactccca     1740

tggccagcac gaggatcagg aatcagttgc tggatttgtg cgactcggtg aaggatgatg     1800

cccggagggt gatctcgacc tttaacattc cacacaccta cctccacgca ccaatcgccg     1860

gaatctccaa cccgcgggcc gcgtgggctt tctaccctgc accgctgcag ccgcggccac     1920

gggaagaggc gcgctcccgg cggcccaagc tgggagccaa gctctaacgg gtgtggcggg     1980

aagtgtggtg gcccgccagc agctgccacg acgctcgctc caccgacgcc cagagctgtg     2040

gccgaggccg ggggctggca cccgctgggc cgccactctc ggggattttg gtggcaaagc     2100

ggaggtcccg ccgaggctgg cgaggtgcgc ggctggctgc taggaaagag atccagacgg     2160

tcgcctggtg cgctggatcc ctgtgccctt tccctgaaac ccagcctggc ctgactgcaa     2220

cctctcccaa cttcagtgcc ggatccccta gacaatcagg gtgggctccc cgctgcgagc     2280

gcgccccaca gccgggtgcc gccaaaggtc tcctgctgtt agcggtgact cacattccca     2340

gtgatttaga aaaactgtgg tgccgagtga aag                                  2373


<210> 3273
<211> 787
<212> DNA
<213> Homo sapiens

<400> 3273
cttgactgga agggtcccca ttccttcttt ccgatccgcg attaccctgg actcgaagtc       60

agcagacccg gttctaggcc agctctgcct ctcaccctct gtgaccttgg gcaaatcata      120

caactctggg actcagtttc ttcctctcta aaacggagat gactgttgct ccatcagtct      180

cagccagcaa gttcagctcc ggcaagtcat ttgattcacc cggtgatgaa atgggggtca      240

accagtctgt gggctttcca cctgtcacag gaccccacct cgtaggctgt ggggatgtga      300

tggagggtca gaatctccag gggagcttct ttcgactctt ctacccctgc caaaaggcag      360

aggagaccat ggagcagccc ctgtggattc cccgctatga gtactgcact ggcctggccg      420

agtacctgca gtttaataag cgctgcgggg gcttgctgtt caacctggcg gtgggatctt      480

gtcgcctgcc tgttagctgg aatggcccct ttaagacaaa ggactctgga taccccttga      540

tcatcttctc ccatggccta ggagccttca ggactttgta ttcagccttc tgcatggagc      600

tggcctcacg tggctttgtg gttgctgtgc cagagcacag atgtgtgtat ttcagggacc      660

ggtcagcggc aaccacctat ttctgcaagc aggccccaga agagaaccag cccaccaatg      720

aatcgctgca ggaggaatgg atccctttcc gtcgagttga ggaaggggag aaggaatttc      780

atgttcg                                                                787


<210> 3274
<211> 3478
<212> DNA
<213> Homo sapiens

<400> 3274
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cggttgcttc      180

attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt      240

gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc tgtcgattga      300

ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt actgtgcttg      360

ctcctgactc tatgtcgcgt cttcaaggag aagaagtcct caccagtgaa cggagacctc      420

tctgaactaa ggataccatg gccacgtcag ccccactacg gagcctggaa gaggaggtga      480

cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt ggccacgtct      540

tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc gtctgcccac      600

tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg gccagcctgg      660

tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag gtgacccggg      720

agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac tactgtgagg      780

acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg      840

ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac cacctgagta      900

ccctaaggag ggacagagac aaaattcagg gcttccaggc aaagggagaa gctgatatcc      960

tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag tttgagcagg     1020

gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg aagctggagc     1080

aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag cttgcccggc     1140

tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca gagctcatgc     1200

aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt gggaaaccca     1260

ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc tctctgcaac     1320

gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag acagtgagcg     1380

tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac tggaagtgcg     1440

tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt gactgtgagc     1500

ctggggtgct aggcagcaag ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg     1560

agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag ggagaagagg     1620

aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa acggacgaag     1680

atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag gaagttctgg     1740

aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac ctctccctgc     1800

ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg gccaacacca     1860

gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc gccctggatt     1920

atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc tacaccttca     1980

ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca ggaacacgcc     2040

tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag atgcttcact     2100

tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag cacctggagc     2160

aggggacccc atatccactg gtagccacct ccccattgct gtggccccct gaaatctcac     2220

tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc ctgctggttt     2280

cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg accacgacct     2340

tggccccagc tctgcactct ctggaataag ggcccgatgc agcattttct tgcccagtgt     2400

ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt ccttaaaccc     2460

cccaggttcc ttcttgcaca aatccactct gctgcccacc ttccctggca ttttaaacag     2520

acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat aaacaaaatc     2580

cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat ctcatggggt     2640

ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat agccaaggag     2700

gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac acggctttgg     2760

ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg tgaggggagt     2820

tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca agacaaacat     2880

ccagtggagc agaacctctc ctgcctcggg agttctgacc gggttcccca gcagggtgtt     2940

aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag agagtggaga     3000

tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa     3060

gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca ggtgcccctc     3120

atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc agtcttgtcc     3180

ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc ctccaccctg     3240

ttctaagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac cattgtctca     3300

gagctgccca ctttgtgtgt gtcacatgct gcctgagtca catgtacatc ttatttctgc     3360

ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt gtattctcat     3420

ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt tgaatgaa       3478


<210> 3275
<211> 3020
<212> DNA
<213> Homo sapiens

<400> 3275
atgggcccct cggggaggcg aggcctgcgg gcgagccctt ctgagggcag ggggtgaggg       60

ggcggcgccc gccagccagg acagcatcct gccgccgtga caagcacgcc tccggttgcc      120

aaaacaaccc aaaaatgtgc ctcaaaacac gttcgcaaag ccccgggccg gccggtcgcc      180

tgcctctcac ctagcccgac cgcccgacgt cctactgccg agcgagggcg agcaagccaa      240

tgagtcgcaa tcccagcagc aatagcccag aagaggacac ggttcccgta ccgaagggtt      300

cagtaccagc agcccgacca tcacgcggcg ggatgtctgt ggttggcatt gacctcggct      360

ttctcaactg ctacattgct gtcgcgagaa gtggcggcat cgagaccatc gccaatgagt      420

acagcgacag gtgtaccccg gcctgtatat cattgggatc aagaactcga gccattggaa      480

atgcagcaaa gagccagata gtcacgaacg taagaaatac aattcatggc ttcaaaaagc      540

ttcatgggcg atcatttgat gatcccattg tgcaaactga aaggatcagg cttccctatg      600

aactgcagaa aatgcctaat ggaagtgcag gagttaaggt gcggtactta gaggaagaga      660

gaccttttgc aattgagcaa gttactggaa tgctgttagc caagcttaaa gagacttcag      720

aaaatgcttt gaagaaacca gtggctgact gtgtgatttc aattcctagc ttttttactg      780

atgccgagag aagatctgtg atggctgcag cccaggttgc aggcttaaat tgtttaaggt      840

tgatgaatga aactactgca gttgcactgg cgtatggaat ttataaacag gatcttcccc      900

cattagatga gaaaccaaga aatgtagtat ttattgatat gggacattct gcctatcagg      960

tcttggtttg tgcttttaac aaaggaaaac ttaaagtctt ggctactacc tttgatccat     1020

atttgggtgg caggaacttt gatgaggctt tagtagacta cttctgtgat gagttcaaga     1080

ccaaatataa gataaatgtg aaagaaaact ctcgggcctt gttgcgttta tatcaggaat     1140

gtgaaaaact aaagaagcta atgagtgcaa atgcatcaga tcttccattg aacattgagt     1200

gtttcatgaa tgaccttgat gtttctagta aaatgaacag ggctcaattt gaacaactgt     1260

gtgcttccct tttggccagg gttgaaccac ctttaaaagc agtaatggaa caagctaact     1320

tacaacgtga agacattagt agtatagaaa ttgtaggagg agcaacacga attcctgcag     1380

tgaaagaaca aatcactaaa ttctttctta aagacataag taccacatta aatgctgatg     1440

aagctgttgc aagaggatgt gcgttacagt gtgcgattct ctcaccagca tttaaagtgc     1500

gtgaattttc cataacagac cttgttccct attcaatcac attaaggtgg aagacctctt     1560

ttgaagatgg aagtggggaa tgtgaagttt tctgtaagaa ccatcctgcc ccattctcaa     1620

aagtcattac tttccacaag aaggaaccat ttgaactaga agcattttat actaatttac     1680

atgaagtgcc ttatcctgat gcaagaattg ggagcttcac tattcagaat gtttttccac     1740

agtctgatgg tgatagttcc aaagtgaagg ttaaagttcg tgttaacatc catggaatct     1800

tcagtgtggc tagcgcatca gtaattgaga agcaaaattt ggaaggcgat cacagtgatg     1860

ctccaatgga gacagaaact tcatttaaaa atgaaaacaa agataatatg gataaaatgc     1920

aggttgatca agaagaaggg catcaaaaat gtcatgctga acacactcca gaagaggaaa     1980

ttgatcatac aggagccaaa acaaagtcag ctgtctcaga caaacaagac cgattaaatc     2040

agacacttaa aaaaggaaaa gtcaaaagta ttgatctacc gatccagagt agcctatgta     2100

gacaactagg ccaagatctt ctcaacagct acattgaaaa tgaggggaag atgatcatgc     2160

aagataagtt agagaaagaa agaaatgatg ctaagaatgc cgttgaagaa tatgtatatg     2220

attttagaga caggctgggc actgtctatg aaaaattcat cactccagaa gacttgagta     2280

aactgtctgc agtattggaa gacacagaaa attggcttta tgaagacgga gaggaccaac     2340

ctaaacaagt ttatgtggat aagcttcaag aactaaagaa atacggccag cctattcaaa     2400

tgaagtacat ggagcatgaa gagagaccaa aagccttaaa tgacttggga aaaaagatcc     2460

aacttgtcat gaaagtgata gaagcttata gaaacaagga tgaaagatat gatcatctgg     2520

atcctactga aatggaaaag gttgaaaaat gtatcagtga tgccatgagt tggctgaata     2580

gtaagatgaa tgcacagaac aaactaagtc tcactcaaga tcctgtggta aaagtttcag     2640

aaatagtagc aaagtcaaag gaactggata atttctgtaa ccccatcatt tacaagccca     2700

aaccaaaagc agaagttcct gaagacaaac caaaagctaa tagtgaacac aatggcccaa     2760

tggatggaca gagtggaact gaaactaaat cagattcaac aaaagacagc tcacagcata     2820

ctaaatcctc tggagagatg gaagtggact aagtcttaat tttaccttca cattaattca     2880

aaccgtgcaa gtaaccacgg ggtccatctt ttacatctgg tacacacaac agacgctcag     2940

ttgttcttaa ccacttttgt catttgtttt ttggagtagt tttgaaaagt gttttatatt     3000

gagtgcactt ctgttcattt                                                 3020


<210> 3276
<211> 5512
<212> DNA
<213> Homo sapiens

<400> 3276
agcgggccgt cggttgggcg cagacaggcc gcagaagatg gagagatgga gccaccccaa       60

gagacaaata ggcctttcag cacacttgat aaccgcagcg ggcaggtcca agtcctgtcc      120

gccaccccgc tattgcagag gaatccctac agcagcccgg atatcatgca cattaaaggg      180

tcggaggctt cttcggtccc ttacgccctg aaccagggca cgacggccct gcctaagaac      240

aagaaccagg agggcaccgg gcaccggctg ctgaacatgc tgagaaaaac tcttaaagag      300

tctgatagtg aagaactgga aataacacag gagacgccaa atttggtgcc atttggggat      360

gtggttggct gcctgggcat tcatataaag aactgcagac attttatgcc taagatcagt      420

ttacaacatt atgctaattt attcattcgc atctctataa acaaagctgt gaaatgtaca      480

aaaatgtgta gcttgctatc caaaaacgat gagaagaaca ctgtaattaa gttcgatgaa      540

gtgaagtatt tttctgtaca ggttcccaga cgttatgatg ataagcggaa taatatttta      600

ttggaactca tacaatatga caatagagaa aaacgtgctt tcttgttagg gagtgttcag      660

atacatcttt atgaggtaat tcagaaaggg tgcttcattg aagaggtcca agtgttgcat      720

ggaaacatat ttgtctgcag gctggaggtg gaatttatgt tctcctatgg aaactttggt      780

tatggatttt cacatcagtt aaaacctctt cagaaaatta ctgagccatc catgtttatg      840

aatcttgcac cacctccaga aagaacagat cccgtgacaa aagttattac accacagaca      900

gtagaatatc cagcattctt atccccagac ctgaatgtta ctgttgggac tccagctgtg      960

caatcctcca accagccatc tgtagtgcga cttgaaaaac ttcagcaaca accccgggaa     1020

aggctggaaa agatgaaaaa agaatataga aatctgaata catggataga taaagctaac     1080

tatttagaaa gcattctaat gccaaaattg gaacataagg attctgagga aactaatata     1140

gatgaggcat ctgaaaacac gaaaagtaat catcctgaag aggagcttga aaatattgta     1200

ggagtagata tccctcttgt aaatgaggaa gctgaaacta ctgcaaatga gttactggat     1260

aatgattctg agaaaggcct gactatacca actttgaacc aatcggacca agataattca     1320

actgctgatg cttctaaaaa tgatgaatca acaccttcac ccacagaagt gcactcattg     1380

tgcactattt ctaaccagga aacaataaaa gcaggcagaa taccaccttt aggtgaacgt     1440

caatcagaaa gcatgccaga cagaaaaatg aaaaatgtat tttttccatt agaagtaaaa     1500

ttaaaagata actatccaag cattttaaaa gcagactcat ctctatcaga ggtggctttt     1560

tcaccaaaag aatataattc accatctttc agaccagaat atatagaatt caaaccaaaa     1620

tttcagtttc agaaattcaa caagaacggt tttgatcctt ttctaaggaa tataaacaaa     1680

atgtcagtca gaaaaagaaa agatcaagat atatacaaat atagaaatat cttaggtgca     1740

gaggtcatag agcatgaaga ccaggatcct ccttatccag cacaatcaaa aactgcagga     1800

cctgctaata caacctgggc ccatgaccct aatatcttca caacaaagat gttagaaact     1860

gagaataagt tagcccctga tcctactatc aatacaataa agggtttaga tacaaagaat     1920

agtttaaaag aaaatctacc aaatgtatct ttaccaagca tcaaaggaga atcatcaagg     1980

gctggaaatg tacaggcaaa cacatgtcac ctctcgaagt ctttaaattt taccccccat     2040

atagaatatt taaaacaatc aatgatactc aagtcaattt taagtgaaaa tctgcaagac     2100

ctttcagaca aattattttc taaaccagaa gttagtatga acagtgaagc aagagagaaa     2160

agtagttctc cacttctaag cattcatgat aaatcatcaa gtagtatgga agacaacgta     2220

ttggaaaaaa aacaagattt aaacaactgg ctttcagaaa aagacatttt aaattcaaag     2280

actactttaa gtcaaataat taaaaatatt cctgcagatt cattttcaga aggtagtcaa     2340

ataattgaaa atattcctgc agattcactt ttagaaggtg gtcaagtaat taaaaatatt     2400

cctgaatatt cactttcaga agggggtcag ataattaaaa atattcctgc agattcattt     2460

ttagaaagtg gaccaggaca atctccagag gtagaagaac atgtctctaa aaaacacttc     2520

gaagctgatg agagagattt tccaattaaa aaaaatagta gtaccaaaaa gaaacattta     2580

ataagcgaag tacctaactc caaatcaggt tcaagtggca ctgtacatga ctacattatg     2640

aggcaaatat tcactgcacc aatattctca gaattggaga tagaagtgaa agagccaagt     2700

gaaacaccaa tgaacttgga aaatcaatta cctacacctt ggaagagaag tttgtcatca     2760

catattctat ttcatgaaga aaatgctgat gaaatagaat tgccacagcc cagatctgct     2820

acaagccaga taatacaagc atttcctata gatacacttt tagaatctgg gataatcaaa     2880

gtgatagaat tagataaaga acaccataag agttctttgc tgggtacggg gatcacttct     2940

cctaaaggaa acctaaagga ttcccaagag tattattcag aaatcagaag cgagacagaa     3000

cctctttctg agcagagtat acccatcatt cccaaagaca ctacttctgt tagtagagct     3060

gaatttatac aggaagacca aaatatgttc ccacaagatt caagttatta ttcaatagca     3120

aataaagaac tgtatttgcc aagaaatggt cagaggcttt gtaaagacaa aaatgatctc     3180

agttctactt tagaaagttt aactaactca ttaatggata aacttagtga atcagatgaa     3240

ataatgttaa aatccttttt aaaaaacatc ttcaatgttt ttttcaaata taatcattct     3300

gaaagaagag gacaaccaga aaaagaatta gaaagactaa ttcaaccttc ttttacaagt     3360

gacacagaac accttgaaga actccaagag gattttgata aagcagacaa attagacaga     3420

aaacctattt tgagtccaaa gttgcgtgtg tttctagaag aactctcaga gtcagaagta     3480

aaacatttaa aatctgaatt aagtaaacaa atccagcatt accttgtaga aagactttca     3540

gaatcaggac atatcaccaa ggaggactta ccaaaaatct atcaaaatct gtatctgatg     3600

aatgagaaag cagagcagaa agggccaaac agttttcagg ggaaatattc tgaaactgtg     3660

aaagaaatca tgtcttttgt caacaatttc aatcatcatt tcatagataa acatttggaa     3720

ataaagctga gatctttttt aaaagagatt ctccaaaact atttcctaaa aaacatttca     3780

gaaagcagtt tatttaatga gacagcatct gagactatat acccaaacat atcttctcta     3840

aggactaaaa gtgtctcaat atcttttcat gaactagaac aagatatttc aaaggggagt     3900

tttggtagaa ggtttgaaat aaacatgaaa tatcctttaa gtaaatctct acaaaactat     3960

ctgatagctt tatcagaaaa tgaattatta catctaaaag ctgatttaag caaacacctc     4020

cagagtcttt ttatagaaaa actttcaaaa tcaggactaa tgacaaaaaa gcaattagaa     4080

gggatcaacc agcatataaa tttgcttaat tctagttcta taccattaaa atatataaaa     4140

acacatttac cttttagaga tgactgtcac tttgtggaga agcattcaga aaagcaaaat     4200

aaatattcaa gaattgttca acaaaccact ttacaaacgg tttctgagga taaacttaga     4260

gaagcagaat tgattcgaga gaaagaaaag aaatattttc ccttacagaa tttaaaggga     4320

aattcatctt taattaagga acagaaaagt tattacacta aggaagaagc taaaacacca     4380

agtttaatca aagtacaacc ttcttccaat gaaaatatcc aggcaagtcc attaagtaag     4440

tcatcagaaa tacttacaga tatactgctt aagaaactaa ggaaagaaca tgtattcacg     4500

cagcttcctc aagcagaaaa ttctgttcat aaaacagaga ttcaagaccc atatagttgg     4560

ggtggtaaat caaaaataac tcaatcaaaa gcttggtgtg aaaagacact gaaaatgaag     4620

tcccttgata gaaaggagca tgtaaacatc tataaatgga ctgttcagga aaaacctgaa     4680

gcagtattaa catcgtatcc aagaattcct aatgccagaa tgccaaggga agatgagtac     4740

ttaaacagaa tcactttccc ttcctggcaa agtagcactt taactcattt caatacagag     4800

actggggaaa aatcaaaatt agaagaccag tattgtcaga cattgaaagg aaataataac     4860

aataataaaa agcatttagt aacatttgca caatacaaaa aagaaataca aactctttat     4920

ataaaaccag atgaaatttg cagtgaaaaa tgtgccaagt tccctgaaat acagtcattc     4980

caatataagg ttgtagaaga tgagaaaaac ttgaaaccac acctcttccc agaattattt     5040

aagatagaag atctaaaacc caaggtccga aaagaaagag accgtgtcgc ccaaccaaaa     5100

aagtcattta acaagatagt caggatacta ccaaccacac tgcccaccac aagaattcac     5160

ctaaagaagt ctgttccaag gacactgctt cactggactg caagaagaac tatacatgat     5220

tgttcagata aatttgagga tttacatgac atgacctcat ttacacacct taaaaaagta     5280

aaatcaagat caaggctttt aggaaaaagc tcagatgata tccataacca tgccagacac     5340

tctgcaagac catatactgc tccggaggtt aacaagcaac gagaaagcta cagtggaaag     5400

tttacaagtc gtcgaatggt ttcatcaggc ttagttcata taaatgataa aacatcagat     5460

tatgaaatgc ataaaatgcg gccaaaaaaa attaaaagag gatattgaaa aa             5512


<210> 3277
<211> 1166
<212> DNA
<213> Homo sapiens

<400> 3277
gccaaatctt aaaggatccg ggagctaagc cagacccggg tggcggtggc agctgcgaaa       60

cccagggagc cgatgccacg tgacccaatg tggacttctt ttaaaccttt ctaatgccca      120

taacccagcc tcagacccat ggagcccacg agagactgcc cgctgttcgg gggcgccttt      180

tccgccatcc tccccatggg ggccattgac gtaagcgacc tccgaccggt cccggacaat      240

caagaagttt tctgccatcc cgtgacggac cagagcctga tagtggaact tctcgagctg      300

caggcccacg tacggggcga agcggctgcg cggtaccact ttgaggatgt tggtggcgtg      360

cagggggcta gggctgtcca tgtggagtct gttcagcctc tcagtttgga gaacctggcc      420

ctgaggggcc gctgtcaaga agcctgggtc ctctctggca agcagcagat agctaaggaa      480

aaccagcagg tgagggcccg agagtgtgta atgtcctgga agggcggtag cggggacgca      540

gagatccagg taagcatcct gactctgatc cccttaggta gcaaaggacg tgacacttca      600

tcaggccttg ctgaggctgc cccagtacca gactgatctc ttgcttacct tcaatcagcc      660

cccgtaagga ggaaggaacg ggcgggtatc tcatgactgg gttcccagga gaatcgggct      720

gggagggaca gaacagggag actcactggt gggatcctcc aaggaagcag gagtgggcca      780

gaggtttggg gtaactgata cccaggtcct ctggggaaca ggaattggca atttccaaac      840

ctcaggcctg gatgatgttc tgtctccatc tgttccccca ccccaagccc tgacaacagg      900

tcatctcttg gccccgaaaa tctgtcacct gcaccctgga gcctgggtga ctttgaacag      960

ctggtgacca gtctgaccct tcacgatcct aacatctttg gtccccagta aaggcgctga     1020

agcactgcat gatgttgctg agaacttggg gactcggttc tgtgaggggg aaaagaggtt     1080

gaaaagaggg tttcctctta tttcttccct gtgcgtaaac ataagacaat ccctcttcag     1140

aataaacttg ctttataatc aatata                                          1166


<210> 3278
<211> 6053
<212> DNA
<213> Homo sapiens

<400> 3278
tggagaacgg gtggacgtgc aggccagaac ccgggaccca cccggctgag cccccagact       60

ctccgctgcc cacgaccctc ggagtggcac cctctcctgg ccgtctcctc tcgtgggtcc      120

cgaagaacgg gtgcaaagcc gagttcgtcc gctgtactgc gcgggcgcgc gtttcgttct      180

tcggttttgc cacggttctg tgactcccta aaggttgagg gctactgaat tagaagaaac      240

gccgagctgg cttctggtgg gctgccgggc gccgggcagc gtgcttggac tggggagggc      300

agggcgtgtt tactctgagt agagcaaccg caagacctcc tttaaaaaat accagttctg      360

agcttcggca ttggagaggc cgcctgtcat tcagcctctt cggaccctct ctcactccct      420

gtcttccgga gcgtgagtga agcccgggtg aggtgttttc ccacacgccg ggggcccgga      480

gctgagaagg ggcatggcca gcatcacgca gctgttcgac gacctgtgtg aggccctcct      540

gccggctgcc aagactcacc tgggccagcg cagtgtgaac cggaagaggg caaagcggag      600

cctcaagaag gtggcctaca atgctctttt cacaaatctt tttcaagatg agactcaaca      660

gctgcagcct gacatgtcaa aactaccagc gagaaacaag atcctcatgt tgtcctttga      720

cttgagagtg ggtggcctgg gccccaaggc cgaccgtttg gaggagcttg tggaggagct      780

ggaagcagcc ccttgctgtc cgcttttgga ggtggggtct gttttggacc tcctggttca      840

gctggcaggg agtggtcccc ctcaagttct gccgagaaaa cgagactact tccttaacaa      900

caagcatgtg gggagaaacg ttccgtacag cggctatgat tgcgacgacc tgagtgtgtt      960

tgagatggac gttcagtctc tgatctccag agaagagtgt ttgtgtcaca gcatgatcca     1020

ggaaacactt caggttatgg aggctgctcc aggcactggc ctgcccaccg tcgggctctt     1080

ctcatttggt gacccttgtg gtgacaggtt cgagagagac acccgggtct cgctcttcgg     1140

ggcccttgtg cacagccgca cttatgacat ggacgtccga ctgggcctgc cccccgtgcc     1200

agacaatgcg gacctctctg ggctggctat taaggtccca ccgagtgtgg atcagtggga     1260

agacgaagga ttccagtcag cgtccaactt gactcctgat tcccagtctg agcccagcgt     1320

gaccccagac gtggacctgt gggaagccgc acttacctat gaggccagca agcggaggtg     1380

ctgggagcga gttggctgcc cccctggcca cagagaggag ccttacctga cggaggcggg     1440

aagggacgct ttcgacaagt tctgcaggct ccaccaaggg gagctccagc tgcttgctgg     1500

gggcgtccta caggccccgc agcccgtgct ggtgaaggag tgcgagctgg tgaaagacgt     1560

gctgaacgtc ttgattgggg tcgtgtctgc cacgttttcg ctctgccagc cggcccaggc     1620

ctttgtggtg aagcggggcg tccacgtgtc aggagcgtct cccgagagca tcagcagcct     1680

gctctcggaa gtggccgagt atgggacctg ctacacgcgc ctgagtcatt tctctctgca     1740

gcccgtcctg gactctttgt acagcaaggg cctcgtgttc caggccttca ccagtggcct     1800

gaggaggtac ctgcagtatt accgggcctg cgtcctttcc actccgccca ccctgagcct     1860

cctcaccatt ggttttctct tcaagaaact tggccggcag ctcaggtacc tggccgagct     1920

ctgtggcgtt ggcgctgtgc tcccgggcac ctgtggagga ggccccaggg ccgcgtttcc     1980

caccggcgtg aagctgctgt cctacctcta ccaggaggct ctgcacaact gcagcaacga     2040

gcactaccct gtactgctgt ccctgctgaa gaccagctgc gagccctaca cccggttcat     2100

ccacgactgg gtgtacagcg gggtgttcag agacgcttat ggcgagttca tgattcaggt     2160

gaaccacgag tacctcagct tccgagataa gttgtactgg acacatggct acgtgctcat     2220

ctccaaagag gtggaggact gtgttcccgt gtttctgaag cacattgccc acgacatata     2280

cgtctgcgga aagaccatta acctgctgaa gctctgctgc ccccggcatt acctctgttg     2340

gtccgacgtc cctgtccccc ggatctcggt gattttctcc cttgaggagt tgaaggagat     2400

tgagaaggac tgtgccgtct acgttgggcg catggagagg gtggcccgcc acagctctgt     2460

cagcaaggag gagaaggaat tacgtatgga aattgcaaaa caagaattaa tcgctcatgc     2520

ccgggaagca gcatccaggg tcctgagtgc actgagtgac cggcagatgt cagaacggat     2580

ggccttggat gcccggaagc gtgagcagtt tcagaggctg aaagaacaat ttgtgaagga     2640

ccaggagcga cgccaggcgg ccaggcagga ggagctggat gatgacttca gctacgcccg     2700

tgaactccga gacagggaga gaaggctgaa gtccctggag gaggagctgg agaggaaggc     2760

gaggcaggca ctggtcgacc actacagcaa gctctctgca gaggcagctc gtcgggagca     2820

gaaggcactg tggagaatcc agaggcaccg actggagagt gcacggcttc gttttctctt     2880

agaagatgag aaacacattc aggagatgct gaaagcagtg tctgaggctc accagcccca     2940

ggagccgcca gacgtcctct tgagcgtgca cccccaggtc acgtctccgg gccctgagca     3000

cccagaggga ggccaaggct gtgattctgg gtctgcagag caacactcgc ctgcctggga     3060

tggctggaac aggccaggcc tgctgacccc acagcccctt aagcctctag cagtgggggc     3120

tggtggcagg gggctgcagc aggcggaggg ggccagaccc ttctctgaca gcctcagcat     3180

tggagacttc ctacctgtgg gcccaggggc tgagccgtcc gtgcagactg gcatggtccc     3240

tctcctggag gtggcgctgc agaccattaa cttggacctg cccccctcag ctcctgggga     3300

ggcacccgca gcagccagca ctcagccctc caggccacag gagtacgact ttagtactgt     3360

cctgaggcca gctgtggcca cctcacctgc accagggccc ctgcaggctg cagagtgcag     3420

cttgggcagc tcagggctac agctgtggga ggacagttgt gggaagatgg atgcctgtgg     3480

ctccgcctcg cgggagactc tgctcccctc acacccaccc aggcgtgctg ctctggagga     3540

ggggagcagc cagcccacag agcggctctt tgggcaggtg tcagggggtg gtcttcccac     3600

aggggactac gcttctgaaa tagctcccac ccggccacgg tggaacaccc acgggcacgt     3660

gtctgacgcc agcatcaggg tcggggagaa tgtgtcagat gtggctccca cccagccacg     3720

gtggaacacc cacggacacg tatccaatgc cagcatcagc ttaggggagt ctgtgtcaga     3780

tgtggctccc actcggccac ggtggaacat ccatggacat gtgtccaacg ccagcatcag     3840

ggtcggggag aatgtgtcag atgtggctcc caccaggcca cggtggaata cccacgggca     3900

cgtgtccaac gccagcatca gggttgggga gaacgtgtcg gacgtggctc ccacccggcc     3960

acggtggaac acccatggac acgtgtccga tgccagcatc agcttggggg agtctgtgtc     4020

agacatggct cccgcccggc cacggtggaa cacccatgga cacgtgtctg atgccagcat     4080

cagcttgggg gagtctgtgt cagacatggc tcccacccgg ccacggtgga acacccacgg     4140

acatgtgtct gacaccagca tcagggttgg ggagaacgta tcggacgtgg ctcccatccg     4200

gtcacggtgc aacacccatg gacacgtgtc cgacgccagc atcagcttgg gggagcctgt     4260

gtcggatgtg gtttccaccc ggccacggtg gaacacccat gtacccatcc ctccgcccca     4320

catggtgctg ggggctctct caccagaagc tgagcccaac acacccaggc cccaacagag     4380

cccccctggc cacacgtccc agtcagcgct cagcctggga gcacagagca ctgtgctgga     4440

ctgtgggcca cggctgcctg tagaagtggg gccatctctg tcctccccca gctcgggctg     4500

cggggagggg agcatcagcg tgggggagaa cgtgtcagac gtggctccca cccaaccatg     4560

gtggcccaac accccgggag acagtgtctc tgaagaacta ggtcagagta gggtggctgg     4620

tggtcaggag tgggactgtg ggacgcacag agcctgggag gccctgggag gagcggggac     4680

actgaggacc tctctccaaa ttggcctctc aactcacagg aagacacagc tgcccagagc     4740

agcccaggcc gtggtgagga ggcggaggca tcggcggcgg aggctcaggg tggggagcag     4800

gcctacctgg caggcctggc agggcagtac cacttggagc ggtacccgga cagttacgag     4860

tccatgtccg agccgcccat tgctcatctt ttgcgccccg tgcttccccg ggccttcgcc     4920

ttccccgtgg acccccaggt ccagtctgcc gctgatgaga ctgctgtgca gctgagcgag     4980

ttgctgacgc tgcccgtgct catgaagcgc tccatcacgg caccgctggc cgcccacatc     5040

tccttggtga acaaggccgc tgtcgactac ttcttcgtgg agctgcacct ggaggcgcac     5100

tatgaggcac tgcggcactt cctgctgatg gaggacggcg agttcgccca gtccctcagc     5160

gacctgctct ttgagaagct tggagctggg caaacgcccg gagagctgct caacccgctg     5220

gtgctgaact ctgtgctgag caaggccctg cagtgcagcc tgcatgggga caccccgcac     5280

gcctccaacc tctccctcgc tctcaagtac ctgcccgagg tgtttgcccc caacgccccg     5340

gatgtgctga gctgcctgga gctcaggtac aaggtggact ggcctctcaa cattgtcatc     5400

accgagggct gcgtgagcaa gtacagcggc gtcttctcct tcctgctgca gctgaagctc     5460

atgatgtggg cgctcaagga cgtctgcttc cacctcaagc gcacagccct gctgagccac     5520

atggccggct ctgtgcagtt ccgtcagctg cagctgttca agcacgagat gcagcatttc     5580

gtgaaggtca tccagggcta catcgccaac cagatcctgc acgtcacctg gtgcgagttc     5640

agggccaggt tggccaccgt gggcgacctg gaggagatcc agcgtgcgca cgcagagtac     5700

ctgcacaagg ccgtcttcag gggcctgctc acggagaagg cggcgcccgt catgaacgtc     5760

atccacagca tcttcagcct cgtgctcaag ttccgcagcc agctcatctc ccaggcctgg     5820

gggccccctg ggggcccgcg gggtgcagag caccccaact ttgcactcat gcagcagtcc     5880

tacaacacct tcaagtacta ctcccacttt ctcttcaaag tggtgaccaa gctggtgaac     5940

cgcggctacc agccccacct ggaggacttt ctgctgcgca tcaacttcaa caactactac     6000

caggacgcct gaggctgctc tgcgggggac gtgcacaata aaggtgttct cgg            6053


<210> 3279
<211> 2398
<212> DNA
<213> Homo sapiens

<400> 3279
gagacctggc ggaccccgtt gctagagcgg cagattgcgg ctcaagcgtc tgagaaaatc       60

taggctgggg tcgagagtcc gcaacagtgg cacctggagc cagacccacc gctttctggt      120

gtcgcgcctt tcaacccggg ggggtaggaa gctttctgtt gctccgcata actgtggtca      180

gctaatagct gctgcctttc cgagacagtt gtcttatgga gttgcttgga gaacgtaaaa      240

taagaggcct aagcaatgcg tctgatgtac acctgtcgtg gaataactgt tcccgctcat      300

tcggccgctg tacctctgct ccctcattcg gagcgtagct gggtatgaat gaaattccgg      360

gcttgtagca cagagaaaac ttctctccca caattggttg gtgctgggga ggaagctcct      420

gattggtgga aagtccgagg aagtgggcaa gccggaggga tttcgtgtac ctcaggtgcc      480

ctcactctga ccggccccct atcattacgt aattttctac gactcgcggt agctcaggca      540

gagcgggttc ctgcagcggc gcgaccctct gacgtctccg cttctaattg gtcaagagct      600

gcgactgcag ttctgaagcc taactggttg cccgtgccgc ctcggaggtg aagtgtactg      660

cgctgattgg cttccaggcg ccggccgcgt gtgatgtccc gggcaacgat tggctctcgc      720

ctaccggggg cttctctcac cgggactcgg gactcccggg aagtggaccg gcagaagagg      780

gggctagcta gctgtctctg cggaccaagg agacccccgc gcccccccgg tgtgaggcgg      840

cctcacaggg ccgggtgggc tggcgagccg acgcggcggc ggaggaggct gtgaggagtg      900

tgtggaacag gacccgggac agaggaacca tggctccgca gaacctgagc accttttgcc      960

tgttgctgct atacctcatc ggggcggtga ttgccggacg agatttctat aagatcttgg     1020

gggtgcctcg aagtgcctct ataaaggata ttaaaaaggc ctataggaaa ctagccctgc     1080

agcttcatcc cgaccggaac cctgatgatc cacaagccca ggagaaattc caggatctgg     1140

gtgctgctta tgaggttctg tcagatagtg agaaacggaa acagtacgat acttatggtg     1200

aagaaggatt aaaagatggt catcagagct cccatggaga cattttttca cacttctttg     1260

gggattttgg tttcatgttt ggaggaaccc ctcgtcagca agacagaaat attccaagag     1320

gaagtgatat tattgtagat ctagaagtca ctttggaaga agtatatgca ggaaattttg     1380

tggaagtagt tagaaacaaa cctgtggcaa ggcaggctcc tggcaaacgg aagtgcaatt     1440

gtcggcaaga gatgcggacc acccagctgg gccctgggcg cttccaaatg acccaggagg     1500

tggtctgcga cgaatgccct aatgtcaaac tagtgaatga agaacgaacg ctggaagtag     1560

aaatagagcc tggggtgaga gacggcatgg agtacccctt tattggagaa ggtgagcctc     1620

acgtggatgg ggagcctgga gatttacggt tccgaatcaa agttgtcaag cacccaatat     1680

ttgaaaggag aggagatgat ttgtacacaa atgtgacaat ctcattagtt gagtcactgg     1740

ttggctttga gatggatatt actcacttgg atggtcacaa ggtacatatt tcccgggata     1800

agatcaccag gccaggagcg aagctatgga agaaagggga agggctcccc aactttgaca     1860

acaacaatat caagggctct ttgataatca cttttgatgt ggattttcca aaagaacagt     1920

taacagagga agcgagagaa ggtatcaaac agctactgaa acaagggtca gtgcagaagg     1980

tatacaatgg actgcaagga tattgagagt gaataaaatt ggactttgtt taaaataagt     2040

gaataagcga tatttattat ctgcaaggtt tttttgtgtg tgtttttgtt tttattttca     2100

atatgcaagt taggcttaat ttttttatct aatgatcatc atgaaatgaa taagagggct     2160

taagaatttg tccatttgca ttcggaaaag aatgaccagc aaaaggttta ctaatacctc     2220

tccctttggg gatttaatgt ctggtgctgc cgcctgagtt tcaagaatta aagctgcaag     2280

aggactccag gagcaaaaga aacacaatat agagggttgg agttgttagc aatttcattc     2340

aaaatgccaa ctggagaagt ctgtttttaa atacattttg ttgttatttt tttcatga       2398


<210> 3280
<211> 3216
<212> DNA
<213> Homo sapiens

<400> 3280
ggcctggagt tccggccagg ccactgcttg ggaagcaaga aggtgaaggc acctctgctg       60

ggccaagcac tcttagggcc gaggggcact gcagctgaca agagctccct gtttcgctga      120

ggcctggagc ccccatggcc tcactgagcc gagccctacg tgtggctgct gcccaccctc      180

gccagagccc tacccggggc atggggccat gcaacctgtc cagcgcagct ggccccacag      240

ccgagaagag tgtgccatat cagcggaccc tgaaggaggg acagggcacc tcggtggtgg      300

cccaaggccc aagccggccc ctgcccagca cggccaacgt ggtggtcatt ggtggaggca      360

gcttgggctg ccagaccctg taccacctgg ccaagctggg catgagtggg gcggtgctgc      420

tggagcggga gcggctgacc tccgggacca cctggcacac ggcaggcctg ctgtggcagc      480

tgcggcccag tgacgtggag gtggagcttc tggcccacac tcggcgggtg gtgagccggg      540

agctggagga ggagacggga ctacacacgg gctggatcca gaatgggggc ctcttcatcg      600

cgtccaaccg gcagcgcctg gacgagtaca agaggctcat gtcgctgggc aaggcgtatg      660

gtgtggaatc ccatgtgctg agcccggcag agaccaagac tctgtacccg ctgatgaatg      720

tggacgacct ctacgggacc ctgtatgtgc cgcacgacgg taccatggac cccgctggca      780

cctgtaccac cctcgccagg gcagcttctg cccgaggagc acaggtcatt gagaactgcc      840

cagtgaccgg cattcgtgtg tggacggatg attttggggt gcggcgggtc gcgggtgtgg      900

agactcagca tggttccatc cagacaccct gcgtggtcaa ctgtgcagga gtgtgggcaa      960

gtgctgtggg ccggatggct ggagtcaagg tcccgctggt ggccatgcac catgcctatg     1020

tcgtcaccga gcgcatcgag gggattcaga acatgcccaa tgtccgtgat catgatgcct     1080

ctgtctacct ccgcctccaa ggggatgcct tgtctgtggg tggctatgag gccaacccca     1140

tcttttggga ggaggtgtca gacaagtttg ccttcggcct ctttgacctg gactgggagg     1200

tgttcaccca gcacattgaa ggcgccatca acagggtccc cgtgctggag aagacaggaa     1260

tcaagtccac ggtctgcggc cctgaatcct tcacgcccga ccacaagccc ctgatggggg     1320

aggcacctga gctccgaggg ttcttcctgg gctgtggctt caacagcgca ggaatgatgc     1380

tgggtggtgg ctgtgggcag gagctggccc actggatcat ccatgggcgc ccggagaagg     1440

acatgcatgg ctatgacatc aggcgcttcc atcactcgct cacggaccac ccccgctgga     1500

tccgagagcg aagccatgag tcctacgcca agaactactc cgtcgtcttc ccccacgatg     1560

agccgctggc cgggcgcaac atgaggagag acccgctgca cgaggaactc cttggacaag     1620

gctgcgtgtt ccaggagcgg catggctggg agcgaccggg atggtttcat ccccgaggcc     1680

cagctccggt cctcgagtac gactactacg gggcttacgg gagccgcgcg cacgaggact     1740

acgcctaccg caggctgctg gcagacgagt acaccttcgc cttcccgccc caccacgaca     1800

cgatcaagaa ggagtgcctg gcctgcagag gggccgccgc tgtgtttgac atgtcctact     1860

tcgggaagtt ctacctggtg gggctggatg caaggaaggc tgccgactgg ctcttctccg     1920

cagatgtcag ccgaccccca ggctccaccg tgtacacgtg catgctcaac caccgtgggg     1980

gcaccgagag tgacctgact gtcagccgcc tggcacccag ccaccaggcc tccccgctgg     2040

cccccgcctt tgaaggggac ggttactacc tggccatggg cggggccgtg gcccagcaca     2100

actggtccca catcaccacc gtgctgcagg accagaagtc ccagtgccag ctcatcgaca     2160

gctccgagga cctgggtatg atcagtatcc agggcccagc cagccgagcc attttgcagg     2220

aggtgctgga cgcagacctg agcaacgagg ccttcccgtt ctccacccac aagctactga     2280

gagccgcagg gcacctggtc cgagccatgc ggctgtcctt tgtgggggag ctgggctggg     2340

agctgcacat tccaaaggcg tcctgcgtgc ctgtgtaccg ggctgtgatg gccgcgggtg     2400

ccaagcacgg cctcatcaac gcagggtacc gcgccatcga ctccctgagc attgagaaag     2460

gctaccggca ctggcacgcg gacctgcggc cagacgacag ccccctggag gcaggcctgg     2520

ccttcacctg caagctcaag tcgccggtgc ccttcctggg gagggaggcc ctggagcagc     2580

agcgggccgc aggcctccgc cggcgcctgg tgtgcttcac catggaggac aaagtaccca     2640

tgtttggcct ggaggccatc tggaggaacg gccaagtggt gggccatgtc cggagggctg     2700

actttgggtt cgccatcgac aagaccatcg cctacggtta catccatgac cccagcggtg     2760

ggccggtctc gctggacttt gtgaagagcg gggactatgc cctggagaga atgggggtga     2820

cctatggtgc ccaggctcac ctgaagtcgc ccttcgaccc caacaacaag agggtgaagg     2880

gaatctactg agggctcaga ccacatgccc catcccatgc tgtccatcca ttctcacagg     2940

tcccaaatgg ccctgggtcc caggaccctg gacccagcca gaacttgtgc cctccctgtc     3000

cttagcctag gcctagtcct gcgaaaaccc ccaaaccaga tacggacaga gaccaagatg     3060

gcccatcctg tggtcactga ctggaaggca gtctctaatc caccccaatc ctcccagaaa     3120

gcaaacctgt aagtgtcttg ggctcaggga ccatggcttg tagccctttc caagcttcta     3180

gaaggtgctt agtaaatact tgataagccc cacgtg                               3216


<210> 3281
<211> 222
<212> DNA
<213> Homo sapiens

<400> 3281
atgtcttacc agcagcagca gtgcaagcag ccctgccagc caccacctcc tgtgtgccgc       60

ctgccaaagc gtccagagcc atgtccaccc ctgaagtgcc ctgagccctg cccaccacca      120

aagtgtccac agccctgccc acctcagcag tgccagcaga aatatcctct ggtgacacct      180

tccccaccct gccagccaaa gtgtccaccc aagagcaagt aa                         222


<210> 3282
<211> 1832
<212> DNA
<213> Homo sapiens

<400> 3282
agctgccagc ccgccaagac ccagacctgg gaggggaggc ccctcctgtt agcccagagg       60

gaaagaaaga actggggcga tccgggacct ggtggcctta gtctttcagg tggaacggtg      120

tgcgacatgg gaaagaaaac caagcggaca gctgacagtt cttcttcaga ggatgaggag      180

gagtatgttg tggagaaggt gctagacagg cgcgtggtta agggacaagt ggaatatcta      240

ctgaagtgga aaggcttttc tgaggagcac aatacttggg aacctgagaa aaacttggat      300

tgccctgagc taatttctga atttatgaaa aagtataaga agatgaagga gggtgaaaat      360

aataaaccca gggagaagtc agaaagtaac aagaggaaat ccaatttctc aaacagtgcc      420

gatgacatca aatctaaaaa aaagagagag cagagcaatg atatcgctcg gggctttgag      480

agaggactgg aaccagaaaa gatcattggg gcaacagatt cctgtggtga tttaatgttc      540

ctaatgaaat ggaaagacac agatgaagct gacctggttc ttgcaaaaga agctaatgtg      600

aaatgtccac aaattgtgat agcattttat gaagagagac tgacatggca tgcatatcct      660

gaggatgcgg aaaacaaaga gaaagaaaca gcaaagagct aaaggagggg atggtctctg      720

tcatttctct ttgtacataa tacattcacc tccctgcctc ctctcctttc tacccacccc      780

tttctatcct aaacacatcc ataaaaaatg tgcttatcac tgtgctccac aggagaaatg      840

ttggtattgg ttctcttgta acataactga tggtctgatt aatgataagt gtctctctgt      900

gaagaccagg catttacata ctgagtgtaa tacccacaat ttttttttcc tttgccctga      960

tctcttcctt ctgcttccct gtgacctcaa gatgagtttc aactttttaa tcaccttaga     1020

gtcttgatct tttcagggtt ggtcgctttt taggttgggg gattttgtta caatgatgtt     1080

gaattttggt ttcttgcttt ggttcttaga acatgttgct gactagctgg cctttgttct     1140

gacatgttga gatggaaagg atgttgccca tctgttaaaa agccaatagc aactgcctac     1200

ctgttggggc tttcccaacc ttgttcagct ctacccagga gaatacaggg tttctggtgt     1260

ggtcttctgg gccaccctct gttgttcatc ctcactcatc ctcccagaat tactccatcc     1320

tttggaagat ttgaaatttt acactgaaat ctgtcaagac actcttttta gccccaggac     1380

tttcggtatt gcttttagca ctccccactt ctgcttctgt aaagtgatat caatttgtga     1440

taaaatgaca agattattaa ctgtgcagat ttgtagctat agtacatgag gatgatgggg     1500

tagggtacaa ttgtctttat tatcatatat ggtatgtatg tatgatttct ttccattcct     1560

catatttaga ctgtatattt atgtaggtgt gagtgattgc ctggtgcttg cttgtgccaa     1620

ggtgctaggc accctccaac cctgccaact tttgtggcct cccaaagcat tcctgttacc     1680

aaagaggctt caaacctgac cctcacttct cagtggaccc gagtttccct tccatgccat     1740

tattttcagt ggggaagttt tagaggtgag ctgttggcca caatatcaat tttaagtgtt     1800

catagcagtt atgtctcctg cattcttggc tc                                   1832


<210> 3283
<211> 308
<212> DNA
<213> Homo sapiens

<400> 3283
ggggcagggc tggtgagcaa gcccgcgggg agcgagcgcg gaggcgggcg ttgctacggc       60

aacgtatatt ttgaatacat ctgtcttcat aaaatacacc atgtccaaaa tctaaaaggg      120

ccaattccaa attattccac cagctttgaa gggaattgaa gcaagaataa caagacagaa      180

gaatagaagg aaggtgatag gatgtgatga tagaatttgt gatagccaag caacaacttt      240

tcctaattcg gcatgttaaa aaataagggt cactcatcta agaaagataa cttggcagtc      300

aatgcagt                                                               308


<210> 3284
<211> 1045
<212> DNA
<213> Homo sapiens

<400> 3284
tagtcaggcg aagtttgcag aatggaatct aattttaatc aagagggagt acctcgacca       60

tcttatgttt ttagtgctga cccaattgca aggccttcag aaataaattt cgatggcatt      120

aagcttgatc tgtctcatga attttcctta gttgctccaa atactgaggc aaacagtttc      180

gaatctaaag attatctcca ggtttgtctt cgaataagac catttacaca gtcagaaaaa      240

gaacttgagt ctgagggctg tgtgcatatt ctggattcac agactgttgt gctgaaagag      300

cctcaatgca tccttggtcg gttaagtgaa aaaagctcag ggcagatggc acagaaattc      360

agtttttcca aggtttttgg cccagcaact acacagaagg aattctttca gggttgcatt      420

atgcaaccag taaaagacct cttgaaagga cagagtcgtc tgatttttac ttacgggcta      480

accaattcag gaaaaacata tacatttcaa gggacagaag aaaatattgg cattctgcct      540

cgaactttga atgtattatt tgatagtctt caagaaagac tgtatacaaa gatgaacctt      600

aaaccacata gatccagaga atacttaagg ttatcatcag aacaagagaa agaagaaatt      660

gctagcaaaa gtgcattgct tcggcaaatt aaagaggtta ctgtgcataa tgatagtgat      720

gatactcttt atggaagttt aactaactct ttgaatatct cagagtttga agaatccata      780

aaagattatg aacaagccaa cttgaatatg gctaatagta taaaattttc tgtgtgggtt      840

tctttctttg aaatttacaa tgaatatatt tatgacttat ttgttcctga attagctaaa      900

accaaaggag aattaatcaa aaccaaagaa gagttaaaaa agagagaaaa tgaatcagat      960

tcattgattc aagagcttga gacatctaat aagaaaataa ttacacagaa tcaaagaatt     1020

aaagaattga taaatataat tgatc                                           1045


<210> 3285
<211> 199
<212> DNA
<213> Homo sapiens

<400> 3285
ctcggcttcc caaaatgttg ggattacagg tgggagccac catgcccggc ctgtaaccct       60

aattattaaa taatttgctg tggaatggat tctaatattc aataatagaa gttgtaattc      120

tgaacccttg gaaatggagg aaggctagag gatatgataa aggagtccaa ggagcatggc      180

ggacaccgac ctgttcatg                                                   199


<210> 3286
<211> 6388
<212> DNA
<213> Homo sapiens

<400> 3286
gttttgatga acacctggct ttattcttgc aatgaagaaa ggttctcaac aaaaaatatt       60

ctccaaagca aagataccat catcatctca ctctcctatc ccatcatcta tgtccaatat      120

gagatctagg tcactttcac ctttgattgg atcagagact ctaccttttc attctggagg      180

acagtggtgt gagcaagttg agattgcaga tgaaaacaat atgcttttgg actatcaaga      240

ccataaagga gctgattcac atgcaggagt tagatatatt acagaggccc tcattaaaaa      300

acttactaaa caggataatt tggctttgat aaaatctctg aacctttcac tttctaaaga      360

cggtggcaag aaatttaagt atattgagaa tttggaaaaa tgtgttaaac ttgaagtact      420

gaatctcagc tataatctaa tagggaagat tgaaaagttg gacaagctgt taaaattacg      480

tgaactcaac ttatcatata acaaaatcag caaaattgaa ggcatagaaa atatgtgtaa      540

tctgcaaaag cttaaccttg caggaaatga aattgagcat attccagtat ggttagggaa      600

gaagttaaaa tctttgcgag tcctcaattt gaaaggcaac aagatatcat cgctccaaga      660

tataagcaag ttgaaaccgc ttcaagattt gatttctctg atcctagttg aaaatccagt      720

tgtgaccctt cctcattacc tccagtttac cattttccac ctccgttcat tggaaagttt      780

ggaaggtcag ccagtaacca ctcaggatag acaggaggct tttgagagat tcagtttaga      840

agaggtagaa agactggaaa gagacctaga aaaaaagatg atagaaactg aagagcttaa      900

gagcaaacaa acaaggttcc ttgaggaaat taaaaatcaa gataaattga ataaatcatt      960

aaaagaggag gccatgttac agaaacagag ctgtgaggaa ctcaagagtg acttaaacac     1020

aaaaaatgaa ttgctaaaac agaagaccat agaattaaca cgagcatgtc agaagcaata     1080

tgagctggaa caggaattgg ccttttataa aattgatgct aaatttgagc cactaaatta     1140

ttatccatca gagtatgctg aaattgataa agccccagat gaaagccctt acattggcaa     1200

atccagatac aagagaaata tgtttgccac agagagttat attattgaca gtgctcaggc     1260

agtacagatc aagaagatgg agccagatga acaacttaga aatgatcaca tgaacttgag     1320

aggccacaca ccactggaca cgcaactgga agacaaagaa aaaaaaataa gtgcagcaca     1380

aactcgacta tcagaactgc atgatgaaat agaaaaggca gaacaacaaa ttttgagagc     1440

tactgaagaa tttaaacaac tggaagaagc tatacaacta aaaaagattt cagaagcagg     1500

gaaagacctt ctttacaagc agttgagtgg tagactacaa cttgtaaata aattacgcca     1560

ggaagctctg gatctagaac tgcagatgga aaagcaaaag caggaaattg ccggaaagca     1620

gaaggagatt aaggacctgc aaatagccat agatagcctg gattccaaag acccaaaaca     1680

ttcccatatg aaggctcaaa agagcggtaa agaacaacag cttgacatta tgaacaagca     1740

gtaccaacaa cttgaaagtc gtttggatga gatactttct agaattgcta aggaaacgga     1800

agagattaag gaccttgaag aacagcttac tgaaggccag atagcagcaa atgaagccct     1860

gaagaaggat ttagaaggtg ttatcagtgg gttgcaagaa tacctgggga ccattaaagg     1920

ccaggcaact caggcccaga atgagtgcag gaagctgcgg gatgagaaag agacattgtt     1980

gcagagattg acagaagtcg agcaggagag agaccagctg gaaatagttg ccatggatgc     2040

agaaaatatg aggaaggagc ttgcagagct agaaagtgcc ctccaagagc agcatgaggt     2100

gaatgcatct ttgcagcaga cccagggaga tctcagtgcc tatgaagctg agctagaggc     2160

tcggctaaac ctaagggatg ctgaagccaa ccagctcaag gaagagttgg aaaaagtaac     2220

aagacttacc cagttagaac aatcagccct tcaagcagaa cttgagaagg aaaggcaagc     2280

cctcaagaat gcccttggaa aagcccagtt ctcagaagaa aaggagcaag agaacagtga     2340

gctccatgca aaacttaaac acttgcagga tgacaataat ctgttaaaac agcaacttaa     2400

agatttccag aatcacctta accatgtggt tgatggtttg gttcgtccag aagaagtggc     2460

agctcgtgtg gatgagctaa gaagaaaact gaaattagga actggggaaa tgaacatcca     2520

tagtccttca gatgtcttag ggaaaagtct tgctgattta cagaaacaat tcagtgaaat     2580

tcttgcacgc tccaagtggg aaagagatga agcacaagtt agagagagaa aactccaaga     2640

agaaatggct ctgcagcaag agaaactggc aactggacaa gaagagttca ggcaggcctg     2700

tgagagagcc ctggaagcaa gaatgaattt tgataagagg caacatgaag caagaatcca     2760

gcaaatggag aatgaaattc actatttgca agaaaatcta aaaagtatgg aggaaatcca     2820

aggccttaca gatctccaac ttcaggaagc tgatgaagag aaggagagaa ttctggccca     2880

actccgagag ttagagaaaa agaagaaact tgaagatgcc aaatctcagg agcaagtttt     2940

tggtttagat aaagaactga agaaactaaa gaaagccgtg gccacctctg ataagctagc     3000

cacagctgag ctcaccattg ccaaagacca gctgaagtcc cttcatggaa ctgttatgaa     3060

aattaaccag gagcgagcag aggagttgca ggaagcagag aggttcagca gaaaggcagc     3120

acaagcagcc agagatctca cccgagcaga agctgagatc gaactcctgc agaatctcct     3180

caggcagaag ggggagcagt ttcgacttga gatggagaaa acaggtgtag gtactggagc     3240

aaactcacag gtcctagaaa ttgagaaact gaatgagaca atggaacgac aaaggacaga     3300

gattgcaagg ctgcagaatg tactagacct cactggaagt gacaacaaag gaggctttga     3360

aaatgtttta gaagaaattg ctgaacttcg acgtgaagtt tcttatcaga atgattacat     3420

aagcagcatg gcagatcctt tcaaaagacg aggctattgg tactttatgc caccaccacc     3480

atcatcaaaa gtttccagcc atagttccca ggccaccaag gactctggtg ttggccttaa     3540

gtactcagcc tcaactcctg ttagaaaacc acgccctggg cagcaggatg ggaaggaagg     3600

cagtcaacct ccccctgcct caggatactg ggtttattct cccatcagga gtgggttaca     3660

taaactgttt ccaagtagag atgcagacag tggaggagat agtcaggaag agagtgagct     3720

ggatgaccaa gaagaacccc catttgtgcc tcctcctgga tacatgatgt atactgtgct     3780

tcctgatggt tctcctgtac cccagggcat ggccctgtat gcaccacctc ctcccttgcc     3840

aaacaatagc cgacctctca cccctggcac tgttgtttat ggcccacctc ctgctggggc     3900

ccccatggtg tatgggcctc caccccccaa cttctccatc cccttcatcc ctatgggtgt     3960

gctgcattgc aacgtccctg aacaccataa cttagagaat gaagtttcta gattagaaga     4020

cataatgcag catttaaaat caaagaagcg ggaagaaagg tggatgagag catccaagcg     4080

gcagtcggag aaagaaatgg aagaactgca tcataatatt gatgatcttt tgcaagagaa     4140

gaaaagctta gagtgtgaag tagaagaatt acatagaact gtccagaaac gtcaacagca     4200

aaaggacttc attgatggaa atgttgagag tcttatgact gaactagaaa tagaaaaatc     4260

actcaaacat catgaagata ttgtagatga aattgagtgc attgagaaga ctcttctgaa     4320

acgtcgctca gagctcaggg aagctgaccg actcctggca gaggctgaga gtgaactttc     4380

atgcactaaa gaaaagacaa aaaatgctgt tgaaaagttc actgatgcca agagaagttt     4440

attgcaaact gagtcagatg ctgaggaatt agaaaggaga gctcaggaaa ctgctgttaa     4500

cctcgtcaaa gctgatcagc agctaagatc gctccaggct gatgcaaagg atttggagca     4560

gcacaaaatc aagcaagaag aaatcttgaa agaaataaac aaaattgtag cagcaaaaga     4620

ctcagacttc caatgtttaa gcaagaagaa ggaaaaactg acagaagagc ttcagaaact     4680

acagaaagac atagagatgg cagaacgcaa tgaggatcac cacctgcagg tccttaaaga     4740

atctgaggtg cttcttcagg ccaaaagagc cgagctggaa aagctgaaaa gccaggtgac     4800

aagtcagcag caggagatgg ctgtcttgga caggcagtta gggcataaaa aggaggagct     4860

gcatctactc caaggaagca tggtccaggc aaaagctgac ctccaggaag ctctgagact     4920

gggagagact gaagtaactg agaagtgcaa tcacattagg gaagtaaaat ctcttctgga     4980

agaactgagt tttcagaaag gagaactaaa tgttcagatt agtgaaagaa aaactcaact     5040

tacacttata aagcaggaaa ttgaaaaaga ggaagaaaat cttcaggttg ttttaaggca     5100

gatgtctaaa cataaaaccg aactaaagaa tattctggac atgttgcaac ttgaaaacca     5160

tgagctacaa ggtttgaagc tacaacatga ccaaagggta tctgaattag agaagactca     5220

ggtggcagtg ctagaggaga aactggagtt agagaatttg cagcagatat cccagcagca     5280

gaaaggggaa atagagtggc agaagcagct ccttgagagg gataaacgag aaatagaacg     5340

aatgactgct gagtcccgag ctttacaatc gtgtgttgag tgtttgagca aagaaaagga     5400

agatctccaa gagaaatgtg acatttggga aaaaaagttg gcacaaacca aaagggtttt     5460

agcagcagca gaagaaaata gcaaaatgga gcaatcaaac ttagaaaagt tggaattgaa     5520

tgtcagaaaa ctgcagcagg aactagacca actaaacaga gacaagttgt cactgcataa     5580

cgacatttca gcaatgcaac agcagctcca agaaaaacga gaagcagtaa actcactgca     5640

ggaggaacta gctaatgtcc aagaccattt gaacctagca aaacaggacc tgcttcacac     5700

caccaagcat caggatgtgt tgctcagtga gcagacccga ctccagaagg acatcagtga     5760

atgggcaaat aggtttgaag actgtcagaa agaagaggag acaaaacaac aacaacttca     5820

agtgcttcag aatgagattg aagaaaacaa gctcaaacta gtccaacaag aaatgatgtt     5880

tcagagactc cagaaagaga gagaaagtga agaaagcaaa ttagaaacca gtaaagtgac     5940

actgaaggag caacagcacc agctggaaaa ggaattaaca gaccagaaaa gcaaactgga     6000

ccaagtgctc tcaaaggtgc tggcagctga agagcgtgtt aggactctgc aggaagagga     6060

gaggtggtgt gagagcctgg agaagacact ctcccaaact aaacggcagc tttcagaaag     6120

ggagcagcaa ttggtggaga aatcaggtga gctgttggcc ctccagaaag aggcagattc     6180

tatgagggca gacttcagcc ttctgcggaa ccagttcttg acagaaagaa agaaagctga     6240

gaagcaggtg gccagcctga aggaagcact taagatccag cggagccagc tggagaaaaa     6300

ccttcttaca gctagagaag ctgaggccca gaagctcaag aaacaggtgt gtgcccagaa     6360

agcccagctg gccagcctgg ggagagag                                        6388


<210> 3287
<211> 1639
<212> DNA
<213> Homo sapiens

<400> 3287
agacaggccg cagaagatgg agagatggag ccaccccaag agacaaatag gcctttcagc       60

acacttgata accgcagcgg gcaggtccaa gtcctgtccg ccaccccgct attgcagagg      120

aatccctaca gcagcccgga tatcatgcac attaaagggt cggaggcttc ttcggtccct      180

tacgccctga accagggcac gacggccctg cctaagaaca agaaccagga gggcaccggg      240

caccggctgc tgaacatgct gagaaaaact cttaaagagt ctgatagtga agaactggaa      300

ataacacagg agacgccaaa tttggtgcca tttggggatg tggttggctg cctgggcatt      360

catataaaga actgcagaca ttttatgcct aagatcagtt tacaacatta tgctaattta      420

ttcattcgca tctctataaa caaagctgtg aaatgtacaa aaatgtgtag cttgctatcc      480

aaaaacgatg agaagaacac tgtaattaag ttcgatgaag tgaagtattt ttctgtacag      540

gttcccagac gttatgatga taagcggaat aatattttat tggaactcat acaatatgac      600

aatagagaaa aacgtgcttt cttgttaggg agtgttcaga tacatcttta tgaggtaatt      660

cagaaagggt gcttcattga agaggtccaa gtgttgcatg gaaacatatt tgtctgcagg      720

ctggaggtgg aatttatgtt ctcctatgga aactttggtt atggattttc acatcagtta      780

aaacctcttc agaaaattac tgagccatcc atgtttatga atcttgcacc acctccagaa      840

agaacagatc ccgtgacaaa agttattaca ccacagacag tagaatatcc agcattctta      900

tccccagacc tgaatgttac tgttgggact ccagctgtgc aatcctccaa ccagccatct      960

gtagtgcgac ttgaaaaact tcagcaacaa ccccgggaaa ggctggaaaa gatgaaaaaa     1020

gaatatagaa atctgaatac atggatagat aaagctaact atttagaaag cattctaatg     1080

ccaaaattgg aacataagga ttctgaggaa actaatatag atgaggcatc tgaaaacacg     1140

aaaagtaatc atcctgaaga ggagcttgaa aatattgtag gagtaggtgg ctttttcacc     1200

aaaagaatat aattcaccat ctttcagacc agaatatata gaattcaaac caaaatttca     1260

ggattgttca gataaatttg aggatttaca tgacatgacc tcatttacac accttaaaaa     1320

agtaaaatca agatcaaggc ttttaggaaa aagctcagat gatatccata accatgccag     1380

acactctgca agaccatata ctgctccgga ggttaacaag caacgagaaa gctacagtgg     1440

aaagtttaca agtcgtcgaa tggtttcatc aggcttagtt catataaatg ataaaacatc     1500

agattatgaa atgcataaaa tgcggccaaa aaaaattaaa agaggatatt gaaaaatgtt     1560

cgctcatttg tgatattata aaacatgttt aactcagaat gatatgtgag gccagcagtc     1620

agaatatcac ttctccatt                                                  1639


<210> 3288
<211> 565
<212> DNA
<213> Homo sapiens

<400> 3288
aacagattgt gggctcccag ggcatatgtc tgcacgctga ggccgaggcg gagaaggggc       60

ttcctgagcg tcccagtaca ctgacagagg gcgtgattct cagtcaccag actcagcttg      120

gagatcttac aatgatggca atcaggagac actgaacgga gatgctacat attcctctct      180

tgcagcaaaa ggttttagaa gcgttcgacc aaacctacaa gataaaagat caccaactca      240

gagccagata acagtgaatg gaaactcagg aggtgccgtg agtcccatga gttactatca      300

gaggccgttt tccccctcgg catattctct cccagcctca ctcaactcca gcattgtcat      360

gcagcacggc acatccctcg attccacaga cacatatccc cagcatgcgc agtctctgga      420

tggcaccacc agcagctcta tccccctgta ccgatcctca gaggaagaga agagagtgac      480

agtcatcaaa gccccgcatt acccagggat cgggcccgtg gatgaatccg gaatccccac      540

agcaattaga acgacagtcg accgg                                            565


<210> 3289
<211> 1468
<212> DNA
<213> Homo sapiens

<400> 3289
gttcctcctc cggccccagg tcaccgccag cacgcgcctg cttcccgtct gcgcgagtcc       60

acgcagctcc ccaggccctt caccagcaca gcagcagcag gcatggcagc aagcgtggag      120

cagcgcgagg gcaccatcca ggtgcagggc caggccctct tcttccgaga ggccctgccc      180

ggcagtgggc aggctcgctt ctctgtactg ctgctgcatg gtattcgctt ctcctccgag      240

acctggcaga acctgggtac actgcacagg ctggcccagg ctggctaccg ggctgtggcc      300

attgacctgc caggtctggg gcactccaag gaagcagcag cccctgcccc tattggggag      360

ctggcccctg gcagcttcct ggcggctgtg gtggatgcct tggagctggg ccccccggtt      420

gtgccagtgg cccccatctg cactgacaaa atcaatgctg ccaactatgc cagtgtgaag      480

actccagctc tgattgtata tggagaccag gaccccatgg gtcagaccag ctttgagcac      540

ctgaagcagc tgcccaacca ccgggtgctg atcatgaagg gggcggggca cccctgttac      600

ctggacaaac cagaggagtg gcatacaggg ctgctggact tcctgcaggg gctccagtga      660

agcccagcac tgctgcaggg ggtgggctgc ctgcctgctc tgagctctct cttgcacgct      720

ctctcttctc tcccaggctc tggctcatgc acatgcaaca ggtgcgtctg tctatatgtc      780

tgggttcttg tcttttgtgg tctgtttgtc ttttctacct ctttctcttg cagtgataga      840

ctgagggggt aaaatcaaga gaaaaaactc tcaggaatca aggaacataa tcctgtggag      900

ggtaatccat tacatgagct tctcctgttc ttccactttc ctgcctggct ttcactcctt      960

cccctgctct gcccagcctt tccctcccac ccactcctcc ttctgcaaat gccctgaagg     1020

ccagccctta ccccaacacc cacttcccca cctccttagg ccccagatac atacatgccc     1080

acatgcacgc ttacatgttt agagccatcc ttgtttccaa atatgaccct tcgcttgagg     1140

gcaactgcat aggtacatct aactctggac tggcatgcac attgtcatgt gcagctttgc     1200

atatacacac atgcatacat gagcctccac acaagcactt gcacacatgt ggactcctaa     1260

ccatgctaac ctcactggct gggaaggtgg ggaccccatg ggccagccct tgcaggaggc     1320

ccttttgcaa ggcttagggt gtggccagcc ctgaaagcta cttggacaca ggtttcagct     1380

ggccccagcc cagaagtgac ccccagaaag ggagggccac cgctttgccc cctgctttta     1440

cccttccttc tgggtgctct acacctca                                        1468


<210> 3290
<211> 2141
<212> DNA
<213> Homo sapiens

<400> 3290
tggaattttt ggcgcgagca gctccgcgcg cgttcacggg ccgttccccc tcacgggagt       60

cctccgcccg ggcgtccgga acagtcgacg gcagactccg gcccgctgag ccacccgagg      120

ggtcccgtgg cctccgcgga cccggaatct gggccctcgc ggacccgcgc cccgcccagt      180

cgccccaggg cttccccaca cccacggagt gaagtcagcc gcggccctgc ctgggaggaa      240

cttaccgtct accgggaaag gtggccagca gatgtgtcgg gcctggtgag agggtgaggc      300

gagacggccc gatcgcccag ggccccggaa gctgcggagg tcacccccgc ctggccttag      360

ctcagggaca ccctggattc acgtgggagc ccctgctcct gcctcccccg tcccaccact      420

gaggctgttg ggccaggcca gtcatgctag aacggcctcc tgcactggcc atgcccatgc      480

ccacggaggg caccccgcca cctctgagtg gcacccccat cccagtccca gcctacttcc      540

gccacgcaga acctggattc tccctcaaga ggcccagggg gctcagccgg agcctcccac      600

ctccgccccc tgccaagggc agcattccca tcagccgcct cttccctcct cggaccccag      660

gctggcacca gctgcagccc cggcgggtgt cattccgggg cgaggcctca gagactctgc      720

agagccctgg gtatgaccca agccggccag agtccttctt ccagcagagc ttccagaggc      780

tcagccgcct gggccatggc tcctacggag aggtcttcaa ggtgcgctcc aaggaggacg      840

gccggctcta tgcggtaaag cgttccatgt caccattccg gggccccaag gaccgggccc      900

gcaagttggc cgaggtgggc agccacgaga aggtggggca gcacccatgc tgcgtgcggc      960

tggagcaggc ctgggaggag ggcggcatcc tgtacctgca gacggagctg tgcgggccca     1020

gcctgcagca acactgtgag gcctggggtg ccagcctgcc tgaggcccag gtctggggct     1080

acctgcggga cacgctgctt gccctggccc atctgcacag ccagggcctg gtgcaccttg     1140

atgtcaagcc tgccaacatc ttcctggggc cccggggccg ctgcaagctg ggtgacttcg     1200

gactgctggt ggagctgggt acagcaggag ctggtgaggt ccaggaggga gacccccgct     1260

acatggcccc cgagctgctg cagggctcct atgggacagc agcggatgtg ttcagtctgg     1320

gcctcaccat cctggaagtg gcatgcaaca tggagctgcc ccacggtggg gagggctggc     1380

agcagctgcg ccagggctac ctgccccctg agttcactgc cggtctgtct tccgagctgc     1440

gttctgtcct tgtcatgatg ctggagccag accccaagct gcgggccacg gccgaggccc     1500

tgctggcact gcctgtgttg aggcagccgc gggcctgggg tgtgctgtgg tgcatggcag     1560

cggaggccct gagccgaggg tgggccctgt ggcaggccct gcttgccctg ctctgctggc     1620

tctggcatgg gctggctcac cctgccagct ggctacagcc cctgggcccg ccagccaccc     1680

cgcctggctc accaccctgc agtttgctcc tggacagcag cctctccagc aactgggatg     1740

acgacagcct aggccctgga caccctcctt gtctcgcctg ccctcctgca ggccttcact     1800

ctcccctgag gctgtcctgg cccggactgt ggggagcacc tccacccccc ggagcaggtg     1860

cacacccagg gatgccctgg acctaagtga catcaactca gagcctcctc ggggctcctt     1920

cccctccttt gagcctcgga acctcctcag cctgtttgag gacaccctag acccaacctg     1980

agccccagac tctgcctctg cacttttaac cttttatcct gtgtctctcc cgtcgccctt     2040

gaaagctggg gcccctcggg aactcccatg gtcttctctg cctggccgtg tctaataaaa     2100

agtatttgaa ccttgggagc acccaagctt gctcatgtgg c                         2141


<210> 3291
<211> 3821
<212> DNA
<213> Homo sapiens

<400> 3291
ctcagcctgg cggttctacc tccgagggtt cgcccgccct tggttttcct tacaccttag       60

cctttggctc ctttgaccac tcgaagcccc acagcgtgtt ccagcggact tcaccagcag      120

acccagaagt ggtgggtgaa acactgcctc tgttcctcct tgagcctgtc gggagctgct      180

gcctgccacc accatgtctg ctgcaaatcc tgagactcca aactcaacca tctccagaga      240

ggccagcacc cagtcttcat cagctgcagc tagccaaggc tgggtgttac cagaaggcaa      300

aatcgtgcca aacactgttt ttgttggtgg aattgatgct aggatggatg aaactgagat      360

tggaagctgc tttggtagat acggttcagt gaaagaagtg aagataatca cgaatcgaac      420

tggtgtgtcc aaaggctatg gatttgtttc gtttgttaat gacgtggatg tccagaagat      480

agtaggatca cagatacatt tccatggtaa aaagctgaag ctgggccctg caatcaggaa      540

acaaaagtta tgtgctcgtc atgtgcagcc acgtcctttg gtagttaatc ctcctcctcc      600

accacagttt cagaacgtct ggcggaatcc aaacactgaa acctacctgc agccccaaat      660

cacgccgaat cctgtaactc agcacgttca gtctgctgca aatcctgaga ctccaaactc      720

aaccatctcc agagaggcca gcacccagtc ttcatcagct gcagctagcc aaggctgggt      780

gttaccagaa ggcaaaatcg tgccaaacac tgtttttgtt ggtggaattg atgctaggat      840

ggatgaaact gagattggaa gctgctttgg tagatacggt tcagtgaaag aagtgaagat      900

aatcacgaat cgaactggtg tgtccaaagg ctatggattt gtttcgtttg ttaatgacgt      960

ggatgtccag aagatagtag gatcacagat acatttccat ggtaaaaagc tgaagctggg     1020

ccctgcaatc aggaaacaaa agttatgtgc tcgtcatgtg cagccacgtc ctttggtagt     1080

taatcctcct cctccaccac agtttcagaa cgtctggcgg aatccaaaca ctgaaaccta     1140

cctgcagccc caaatcacgc cgaatcctgt aactcagcac gttcaggctt actctgctta     1200

tccacattca ccaggtcagg tcatcactgg atgtcagttg cttgtatata attatcagga     1260

atatcctact tatcccgatt cagcatttca ggtcaccact ggatatcagt tgcctgtata     1320

taattatcag ccatttcctg cttatccaag atcaccattt caggtcactg ctggatatca     1380

gttgcctgta tataattatc aggcatttcc tgcttatcca aattcaccat ttcaagtcgc     1440

cactggatat cagttccctg tatacaatta tcagccattt cctgcttatc caagttcacc     1500

atttcaggtc actgctggat atcagttgcc tgtatataat tatcaggcat ttcctgctta     1560

tccaaattca ccatttcaag tcgccactgg atatcagttc cctgtataca attatcaggc     1620

atttcctgct tatccaaatt caccagttca ggtcaccact ggatatcagt tgcctgtata     1680

caattatcag gcatttcctg cttatccaag ttcaccattt caggtcacca ctggatatca     1740

gttgcctgta tataattatc aggcatttcc tgcttatcca aattcagcag ttcaggtcac     1800

cactggatat cagttccatg tatacaatta ccagatgcca ccgcagtgcc ctgttgggga     1860

gcaaaggaga aatctgtgga ccgaagcata caaatggtgg tatcttgtct gtttaatcca     1920

gagaagagac tgataaattc cgttgttact caagatgact gcttcaaggg taaaagagtg     1980

catcgcttta gaagaagttt ggcagtattt aaatctgttg gatcctctca gctatctagt     2040

ttcatgggaa gttgctggtt ttgaatatta agctaaaagt tttccactat tacagaaatt     2100

ctgaattttg gtaaatcaca ctgaaacttt ctgtataact tgtattatta gactctctag     2160

ttttatctta acactgaaac tgttcttcat tagatgttta tttagaacct ggttctgtgt     2220

ttaatatata gtttaaagta acaaataatc gagactgaaa gaatgttaag atttatctgc     2280

aaggattttt aaaaaattga aacttgcatt ttaagtgttt aaaagcaaat actgactttc     2340

aaaaaagttt ttaaaacctg atttgaaagc taacaatttt gatagtctga acacaagcat     2400

ttcacttctc caagaagtac ctgtgaacag tacaatattt cagtattgag ctttgcattt     2460

atgatttatc tagaaattta cctcaaaagc agaattttta aaactgcatt tttaatcagt     2520

ggaactcaat gtatagttag ctttattgaa gtcttatcca aacccagtaa aacagattct     2580

aagcaaacag tccaatcagt gagtcataat gtttattcaa agtattttat cttttatcta     2640

gaatccacat atgtatgtcc aatttgattg ggatagtagt taggataact aaaattctgg     2700

gcctaatttt ttaaagaatc caagacaaac taaactttac tgggtatata accttctcaa     2760

tgagttacca ttctttttta taaaaaaaat tgttccttga aatgctaaac ttaatggctg     2820

tatgtgaaat ttgcaaaata ctggtattaa agaacgctgc agctttttta tgtcactcaa     2880

aggttaatcg gagtatctga aaggaattgt ttttataaaa acattgaagt attagttact     2940

tgctataaat agatttttat ttttgttttt tagcctgtta tatttccttc tgtaaaataa     3000

aatatgtcca gaagaggcat gttgtttcta gattaggtag tgtcctcatt ttatattgtg     3060

accacacagc tagagcacca gagccctttt gctatactca cagtcttgtt ttcccagcct     3120

cttttactag tctttcagga ggtttgctct tagaactggt gatgtaaaga atggaagtag     3180

ctgtatgagc agttcaaagg ccaagccgtg gaatggtagc aatgggatat aatacctttc     3240

taagggaaac atttgtatca gtatcatttg atctgccatg gacatgtgtt taaagtggct     3300

ttctggccct tctttcaatg gcttcttccc taaaacgtgg agactctaag ttaatgtcgt     3360

tactatgggc catattacta atgcccactg gggtctatga tttctcaaaa ttttcattcg     3420

gaatccgaag gatacagtct ttaaacttta gaattcccaa gaaggcttta ttacacctca     3480

gaaattgaaa gcaccatgac tttgtccatt aaaaaattat ccatagtttt tttagtgctt     3540

ttaacattcc gacatacatc attctgtgat taaatctcca gatttctgta aatgatacct     3600

acattctaaa gagttaattc taattattcc gatatgacct taaggaaaag taaaggaata     3660

aatttttgtc tttgttgaag tatttaatag agtaaggtaa agaagatatt aagtcccttt     3720

caaaatggaa aattaattct aaactgagaa aaatgttcct actacctatt gctgatactg     3780

tctttgcata aatgaataaa aataaacttt ttttcttcaa a                         3821


<210> 3292
<211> 1080
<212> DNA
<213> Homo sapiens

<400> 3292
gcccggggct ctgatgtcac cgcgcggctg cgacggccca ggagcgcgtc tcggcgggag       60

cctcaggacc cacgcagcca cccagcctca gcactcatct gcgcagccat ggaggccctg      120

ggacctgggg gcgaccgcgc ctccccggcc tcgtccacta gcagcctgga cctgtggcat      180

ctgtccatgc gcgcggactc ggcctacagc tctttctccg cagcctccgg cggccccgag      240

ccgcgcacgc agtcgccggg gacagacctc cttccttacc tagactggga ctacgtgcgt      300

gtggtttggg gcggcccggg ccccgccccg cccgacgctg ccctttgcac atccccgcgg      360

ccccggcccg cggttgcagc ccgcagtggg ccgcagccaa cagaggtccc ggggaccccg      420

ggaccactga acaggcaggc caccccgctg ctgtacgcgc tggcggccga ggcggaggcc      480

gcggcgcagg ctgccgagcc gcccagcccg ccggcctcga gggccgccta ccgccagcgg      540

cttcagggcg cgcagcggcg agtgctccgg gagacgtcgt tccagcgcaa ggagctccgc      600

atgagcctgc ccgcccgtct gcggcccact gtcccagcgc ggcccccggc gactcacccg      660

cgctccgcct cgctcagcca cccgggcggg gagggggagc cggcgcgctc ccgggctccc      720

gcgccaggaa ctgccggccg gggtcccctc gccaaccagc agcggaagtg gtgcttctca      780

gagccaggaa agctggatcg tgtgggtcgg ggcggtgggc cggcgcggga atgcctgggt      840

gaggcctgct ccagctctgg cctccctggg cccgagccct tggagttcca gcatccggcg      900

ctggctaagt ttgaagatca cgaggtcgga tggctgcccg agacgcaacc ccaaggctcc      960

atgaacctgg actccgggtc cttgaagctc ggtgatgcct tcaggcccgc cagtcggagt     1020

cggagcgctt caggcgaagt cttgggttcc tggggaggat caggagggac catacccatt     1080


<210> 3293
<211> 970
<212> DNA
<213> Homo sapiens

<400> 3293
gtgattaggg ccaacatggc cgccgccgcc gcttggagct gaagtgccgc cgccgccggg       60

cagccacggg gaatccgccc gcatcgccgc cctcgccggc cgggcggccg tggggcccag      120

agcgccggag gccagggctg gggcggcacc gcgcagcggc cacggggtcc cgttagagca      180

gcgcccggcg gctatgccga gagcccggag cggccggagg agcagagggg ccggcgggag      240

ggaggaaacc tttctgcgag tacgagccaa ccggcagacc cgactgaatg ctcggattgg      300

gaaaatgaaa cggaggaagc aagatgaagg gcagagggaa ggctcctgca tggctgagga      360

tgatgctgtg gacatcgagc atgagaacaa caaccgcttt gaggagtatg agtggtgtgg      420

acagaagcgg atacgggcca ccactctcct ggaaggtggc ttccgaggct ctggcttcat      480

catgtgcagc ggcaaagaga acccggacag tgatgctgac ttggatgtgg atggggatga      540

cactctggag tatgggaagc cacaatacac agaggctgat gtcatcccct gcacaggcga      600

ggagcctggt gaagccaagg agagagaggc acttcggggc gcagtcctaa atggcggccc      660

tcccagcacg cgcatcacac ctgagttctc taaatgggcc agtgatgaga tgccatccac      720

cagcaatggt gaaagcagca agcaggaggc catgcagaag acctgcaaga acagcgacat      780

cgagaaaatc accgaagatt cagctgtgac cacgtttgag gctctgaagg ctcgggtcag      840

agaacttgaa cggcagctat ctcgtgggga ccgttacaaa tgcctcatct gcatggactc      900

gtactcgatg cccctaacgt ccatccagtg ttggcacgtg cactgcgagg agtgctggct      960

gcggaccctg                                                             970


<210> 3294
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3294
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cgaagtcctc      180

accagtgaac ggagacctct ctgaactaag gataccatgg ccacgtcagc cccactacgg      240

agcctggaag aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc      300

attgactgtg gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg      360

agccgccccg tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg      420

tggcaactgg ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag      480

ccgggagagg tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag      540

ctgcactact actgtgagga cgacgggaag ctgctgtgcg tg                         582


<210> 3295
<211> 1415
<212> DNA
<213> Homo sapiens

<400> 3295
aaaggggcgg cccggcccgg cccggaagct acagcagcgg cgcggagact gcggggcggg       60

ccatggcggc gaacctgagc cggaacgggc cagcgctgca agaggcctac gtgcgggtgg      120

tcaccgagaa gtccccgacc gactgacagg cgagggcgtg aacgatgtgc ggaagggagc      180

ctgtgccagc cacgtcagca ccatggccag cttcctgaag ggggcccatg tgaccatcaa      240

cgcacgggcc gaggaggatg tggagcctga gtgcatcatg gagaaggtgg ccaaggcttc      300

aggtgccaac tacagctttc acaaggagag tggccgcttc caggacgtgg gaccccaggc      360

cccagtgggc tctgtgtacc agaagaccaa tgccgtgtct gagattaaaa gggttggtaa      420

agacagcttc tgggccaaag cagagaagga ggaggagaac cgtcggctgg aggaaaagcg      480

gcgggccgag gaggcacagc ggcagctgga gcaggagcgc cgggagcgtg agctgcgtga      540

ggctgcacgc cgggagcagc gctatcagga gcagggtggc gaggccagcc cccagaggac      600

gtgggagcag cagcaagaag tggtttcaag gaaccgaaat gagcaggagt ctgccgtgca      660

cccgagggag attttcaagc agaaggagag ggccatgtcc accacctcca tctccagtcc      720

tcagcctggc aagctgagga gccccttcct gcagaagcag ctcacccaac cagagaccca      780

ctttggcaga gagccagctg ctgccatctc aaggcccagg gcagatctcc ctgctgagga      840

gccggcgccc agcactcctc catgtctggt gcaggcagaa gaggaggctg tgtatgagga      900

acctccagag caggagacct tctacgagca gcccccactg gtgcagcagc aaggtgctgg      960

ctctgagcac attgaccacc acattcaggg ccaggggctc agtgggcaag ggctctgtgc     1020

ccgtgccctg tacgactacc aggcagccga cgacacagag atctcctttg accccgagaa     1080

cctcatcacg ggcatcgagg tgatcgacga aggctggtgg cgtggctatg ggccggatgg     1140

ccattttggc atgttccctg ccaactacgt ggagctcatt gagtgaggct gagggcacat     1200

cttgcccttc ccctctcaga catggcttcc ttattgctgg aagaggaggc ctgggagttg     1260

acattcagca ctcttccagg aataggaccc ccagtgagga tgaggcctca gggctccctc     1320

cggcttggca gactcagcct gtcaccccaa atgcagcaat ggcctggtga ttcccacaca     1380

tccttcctgc atcccccgac cctcccagac agctt                                1415


<210> 3296
<211> 705
<212> DNA
<213> Homo sapiens

<400> 3296
cgcgccgaaa ttcaaaggaa taaatagttc cggcgcgggt gttgagagcg gtgtggcagg       60

tgttgtagcc gctatggtga agttcgcttt gtagcggccc cggctagaga gttgttctgt      120

tccctgcctt tgtgacccgg aggagctttt ggggtggtta ttggtggtag aaataaatat      180

ttaatcaatg gagtcaatgc caacaacacc agagtacagg atctcttctg ttctgttggc      240

cttaatgtta acaaccctca ctttctcatc atgcagggcc gaattacaaa agtattgaat      300

atgaaacctc cagagatttt atccatgata gaagaagcag ctggaaccag gatgtatgaa      360

tacaaaaaaa tagctgcaca gaaaactata gaaaaaaagg aggctaagct gaaagaaatt      420

aagacgatac ttgaagaaga gattactcca accattcaaa aattaaaaga ggaaagatcg      480

tcctacttgg agtaccaaaa agtaatgaga gaaatagaac atttgagtcg tttatatatt      540

gcttatcagt ttttgctggc tgaagatacc aaagtacgct cagctgagga attaaaagaa      600

atgcaagata aagttataaa gcttcaggaa gaattgtctg agaatgataa aaaaataaaa      660

gcacttaatc atgaaataga agaattggaa aaaagaaaag ataag                      705


<210> 3297
<211> 1557
<212> DNA
<213> Homo sapiens

<400> 3297
catcagtgca gtcacaacag gagcagttgt cccagtcaga tccatctccg tcaccaaact       60

catgtagttc ctttgagcta atagacatgg atgctggcag cttgtatgaa ccagtttctc      120

cccattggtt ttattgtaag ataatagatt ctaaggagac atggattcct ttcaactctg      180

aggattcaca gcagctggaa gaggcatata gctctggaaa aggttgtaat gggagagttg      240

ttcctactga tgggggcaga tatgatgttc atttggggga gaggatgcgg tatgctgtat      300

actgggatga actggcatcg gaagtgagac gatgtacgtg gttttacaag ggggacaaag      360

acaataagta tgttccctac tcggagagct tcagccaagt tttagaggaa acttacatgc      420

ttgctgtaac tttggatgaa tggaaaaaga aactggaatc tcccaacaga gaaattatta      480

ttttacacaa tccaaaggag aacctttaca aatagatcac ttggtttttg tagtccatgg      540

gattggacca gcttgtgatc tccgctttcg aagcattgta cagtgtgtta atgattttcg      600

cagtgtttcc ttgaacttgc tacagacaca ttttaagaaa gcccaagaaa atcagcagat      660

tgggagggta gaatttcttc cagtcaactg gcacagtcct ttgcattcta ctggtgtgga      720

tgtagatctg cagcgaataa ccctgcccag cattaaccgc ctcaggcact tcaccaatga      780

cacaattctg gatgtcttct tctacaatag tcccacctac tgtcagacta ttgtggacac      840

agttgcttct gaaatgaacc gaatatacac actttttcta cagaggaacc ctgatttcaa      900

agggggtgta tccattgctg gtcatagttt aggttcgctt atattgtttg atatcctaac      960

aaatcagaaa gattctttgg gggatattga cagtgaaaag gattcgctaa atattgtaat     1020

ggatcaagga gatacaccta cactagagga agatttgaag aaacttcagc tctctgaatt     1080

ctttgatatc tttgagaagg agaaagtaga taaggaagct ctggctttat gtacagaccg     1140

agatcttcag gaaataggaa ttcctttagg accaagaaag aatctgagtt ctgcagtagc     1200

agtaatacta gaaatggtga ctatctggat gttggcattg ggcaggtgtc tgtgaaatac     1260

ccccggctca tctataaacc agagatattc tttgcctttg gatctcccat tggaatgttc     1320

cttactgtcc gaggactaaa aagaattgat cccaactaca gatttccaac gtgcaaaggt     1380

ttcttcaata tttatcaccc ttttgatcct gtggcctata ggattgaacc aatggtggtc     1440

ccaggagtgg aatttgagcc aatgctgatc ccacatcata aaggcaggaa gcggatgcac     1500

ttagaactga gagagggctt gaccaggatg agtatggacc ttaagaacaa cttgcta        1557


<210> 3298
<211> 2251
<212> DNA
<213> Homo sapiens

<400> 3298
caggtcctag agcagctcca gcaggatggc ggctccagcg tctctaaggc ctgcaggggg       60

tccagcccca tggggggcgc cctaggcctc cgacagctcc ccatctgtgc tcctgcctgc      120

cggccatcct caggccactc gccatgggcg gctgcttctc caaacccaaa ccagtggagc      180

tcaagatcga ggtggtgctg cctgagaagg agcgaggcaa ggaggagctg tcggccagtg      240

ggaagggcag cccccgggcc taccagggca atggcacggc ccgccacttc cacacggagg      300

agcgcctgtc cacccctcac ccctacccca gccctcagga ttgcgtggag gctgctgtct      360

gccacgtcaa ggacctcgag aatggccaga tgcgggaagt ggagctgggc tgggggaagg      420

tgttgctggt gaaggacaat ggggagttcc acgccctggg ccataagtgt ccgcactacg      480

gcgcacccct ggtgaaaggc gttctgtccc gtggtcgggt gcgctgcccc tggcacggcg      540

cctgcttcaa catcagcact ggggacctgg aggacttccc tggcctggac agtctacaca      600

agttccaggt gaagattgag aaggagaagg tgtacgtccg ggccagcaag caggccctac      660

agctgcagcg aaggaccaag gtgatggcca agtgtatctc tccaagtgct gggtacagca      720

gtagcaccaa tgtgctcatt gtgggtgcag gtgcagctgg cctggtgtgt gcagagacac      780

tgcggcagga gggcttctcc gaccggatcg tcctgtgcac gctagaccgg caccttccct      840

acgaccgtcc caagctcagc aagtccctgg acacacagcc tgagcagctg gccctgaggc      900

ccaaggagtt tttccgagcc tatggcatcg aggtgctcac cgaggctcag gtggtcacag      960

tggacgtgag aactaagaag gtcgtgttca aggatggctt caagctggag tacagcaagc     1020

tgctgctggc accagggagc agccccaaga ctctgagctg caaaggcaaa gaagtggaga     1080

acgtgttcac tatccggacg ccagaggatg ccaatcgcgt ggtgaggctg gcccgaggcc     1140

gcaacgtggt cgtcgtggga gccggcttcc tggggatgga ggtggccgct tacctgacgg     1200

agaaggccca ctctgtgtct gtggtggagc tggaggagac gcccttcagg aggttcctgg     1260

gggagcgcgt gggtcgagcc ctcatgaaga tgtttgagaa caaccgggtg aagttctaca     1320

tgcagacgga ggtgtctgag ctgcggggcc aggagggaaa gctgaaggag gttgtgctga     1380

agagcagcaa ggtcgtgcgg gctgacgtct gcgtggtggg cattggtgca gtgcccgcca     1440

caggcttcct gaggcaaagc ggcatcggtt tggattcccg aggcttcatc cctgtcaaca     1500

agatgatgca gaccaatgtc ccaggcgtgt ttgcagctgg cgatgctgtc accttccccc     1560

ttgcctggag gaacaaccgc aaagtgaaca ttccacattg gcagatggct catgctcagg     1620

ggcgcgtggc agcccagaac atgttggcgc aggaggcgga gatgagcact gtgccctacc     1680

tctggaccgc catgtttggc aagagcctgc gctacgcggg ctacggagaa ggcttcgacg     1740

acgtcatcat ccagggggat ctggaggagc tgaagtttgt ggctttttac actaaaggcg     1800

acgaggtgat cgccgtggcc agcatgaact acgatcccat tgtgtccaag gtcgctgagg     1860

tgctggcctc aggccgtgcc atccggaagc gggaggtgga gctgtttgtg ctgcacagca     1920

agactggcga catgtcctgg cttacgggga aaggatcctg agctcacatg cagtagactt     1980

gggcaggcaa agggggcacc aagggcacag gccaagcctt gggggcaggt gccaatctcc     2040

agtcccagga tcccccaggg cagaacctga gccctcccag tgcttgcctt cagccacctg     2100

gctcccctcc tgggaggcct ctgctggatc cagaagatgc tcaaccctca aggcctctgc     2160

tgccactgac agctggcact ggaggcagga caagccctgc ctcttctccc tctattggga     2220

ctggtcccct gaagaaccct gcaacacgtt a                                    2251


<210> 3299
<211> 617
<212> DNA
<213> Homo sapiens

<400> 3299
attttcctgc agtcactgct ggcagatgat agagccagga tttgaaagca ggcagcctgg       60

ctccagaccc tgtgctctta actcccgttt tgcatcaaga acagaatcct atgaaaggat      120

agcagcatca aggagcattg tgtacatgca gaagtgcaca gtacctggag tgaaactgct      180

tgtgttcgat ttctgatacc attcataact ggctgtgtga tctcaaataa gaaaactgaa      240

gaaccagctg ggcgcggtag ctcacgcctg taatcccagc actttgggag gctgaggcgg      300

gtggattacc tgagaacctc taaaatgcag acctccagct ctagatctgt gcacctgagt      360

gaatggcaga agaattactt cgcaattaca tctggcatat gtaccggacc gaaggcagat      420

gcataccgtg cacagatatt acgcattcag tatgcatggg caaactctga gatttcccag      480

gtctgtgcta ccaaactgtt caaaaaatat gcagagaaat attctgcaat tattgattct      540

gacaatgttg aatctgggtt gaataattat gcagaaaaca ttttaacttt ggcaggatct      600

caacaaacag atagtga                                                     617


<210> 3300
<211> 1198
<212> DNA
<213> Homo sapiens

<400> 3300
ggcagcttgt tttgccttca cgggagtaga aggaggcggc gtccggccgc ggccgacggt       60

agttcgcttc cccgagagtg cgcggaggcc cgggtgcgag gagggcctgt ttctcttcag      120

ccctggttca ttcacctcgc ggaccgaggg ccccgccgtc aggagccggc gaccgtgccc      180

tggtgcgagc tgtgatggtc attgtcctcc agagcagtga tggaggaaat accagcccag      240

gaagcagcag ggtcaccaag ggtccagttt cagtctttgg agacccagtc tgagtgtctg      300

tccccagagc ctcagtttgt gcaggacacc gacatggaac agggactcac tgggggcata      360

cttctccgcc ttcccaccac ccggattcat agtgtgaatt cctgcccggc cctgagtcat      420

acccaggcaa gtgctttctc tggagaaaca cttgccgtcc ttacagcagg aatctccaag      480

agatggccca agtatcggct tcccatcgat attgctcgtc cctgctcgga aactcctttt      540

ccacgattgt gagatattaa aattgactga tggaatagaa gctccccagg atgccaccac      600

tgtgtaaaat cgcagctcct caaattacct ctgtttaatt tcaaatgtta gggtccaagg      660

aagccctctg ttgcaaccag atatgttttg aacccagttc attcagaaac catggttggt      720

ggtcatcatc tacttgtatt gtgaaaaacc agaaattcca aattcagctc ttcagttatg      780

gtcttttcat attattttag aatgtgaaac ttatgctgtg tgcccctcct tttatgtggc      840

gaacacaacc tgccccgtat ggtgcctaac tctcctgtga accctgggct tccctcatgt      900

ttaacattct ggtttcctcc ttccttgaag tccctgtggc cctcttcaag gtcctacctt      960

cctacccttt attctttgtg gttctgtaca gattgatgca attatattgc ctttcctgat     1020

taagtgttcc ttactctgtc cttgatggag gggagaaggg agggcaaaga agttaaattt     1080

atttcagggc atcaaattga atatctactt aataactttg taaactgtaa agtgacatac     1140

atataattgt aaagtactgt taattttatc taataattac agagtttcca acagttaa       1198


<210> 3301
<211> 871
<212> DNA
<213> Homo sapiens

<400> 3301
ggaaacgcgg cccaaactgt tacgaagtgg aagaggctgg atagctcttc ataattaatc       60

aggaatggga ggtttgagca ggtttacttg atgagggaaa cattatagcc tcgccaattc      120

attcattatt tcaacaatta cttattgaac acctgctacg tggcagacag ccaaggaggc      180

gggtttggtg cggccactcc aaggccaaag cgagaaaatc ttactgcgca cgcgcaatag      240

acagccgatg gagccaccga tggagccgtc cggaggggag caagagcccg gagccgtcag      300

gttcctggac ctgccctggg aagacgtgct gctcccacac gtcctgaacc gggtcccgct      360

gcgccagctg ctccggctgc agcgcgttag ccgggccttc cggtcgctgg tgcagcttca      420

cctggccggg ctgcgtcgct tcgatgccgc gcaggtgggt ccgcagatcc cgcgggccgc      480

attggcccgg ctgctgcggg atgccgaggg gctgcaggag ctggcactgg cgccgtgtca      540

cgaatggctg tcagacgagg acctggtgcc ggtgctggcg cggaatccgc agctgcggag      600

tgtggcgttg ggcggctgcg ggcaactgag tcgccgggcg cttggggctt tggccgaggg      660

ctgcccacgc ctgcagcgcc tgtcgctcgc gcactgtgac tgggtggacg ggctggcgct      720

gcgcggcctc gctgatcgct gcccggccct ggaggagctg gatctcaccg cctgccgcca      780

gctcaaggac gaggccatcg tgtacctggc gcagaggcgc ggcgctggtc tccgcagcct      840

ctctctggcc gtcaacgcca acgtggggga c                                     871


<210> 3302
<211> 2514
<212> DNA
<213> Homo sapiens

<400> 3302
gttactcact ataaacaata tccacccaac acaagcaaag tttattccta ctttgaatgc       60

cgtgaaaaga agacagaaaa ctccaaatta aggaaggtga aatatgagga aacagtattt      120

tatgggttgc agtacattct taataagtac ttaaaaggta aagtagtaac caaagagaaa      180

atccaggaag ccaaagatgt ctacaaagaa catttccaag atgatgtcgt taatgaaaaa      240

ggatggaact acattcttga gaaatatgat gggcatcttc caatagaaat aaaagctgtt      300

cctgaaggct ttgtcattcc cagaggaaat gttctcttca cggtggaaaa cacagatcca      360

gagtgttact ggcttacaaa ttggattgag actattcttg ttcagtcctg gtatccaatc      420

acagtggcca caaattctag agagcagaag aaaatattgg ccaaatattt gttagaaact      480

tctggtaact tagatggtct ggaatacaag ttacatgatt ttggctacag aggagtctct      540

tcccaagaga ctgctggcat aggagcatct gctcatttgg ttaacttcaa aggaacagat      600

acagtagcag gacttgctct aaataaaaaa tattatggaa cgaaagatcc tgttccaggc      660

tattctgttc cagcagcaga acacagtacc ataacagctt gggggaaaga ccatgaaaaa      720

gatgcttttg aacatattgt aacacagttt tcatcagtgc ctgtatctgt ggtcagcaat      780

agctatgaca tttataatgc gtgtgagaaa atatggggtg aagatctaag acatttaata      840

gtatcgagaa gtacacaggc accactaata atcagacctg attctggaaa ccctcttgac      900

actgtgttaa aggttttgga gattttaggt aagaagtttc ctgttactga gaactcaaag      960

ggttacaagt tgctgccacc ttatcttaga gttattcaag gggatggagt agatattaat     1020

accttacaag agattgtaga aggcatgaaa caaaaaatgt ggagtattga aaatattgcc     1080

ttcggttctg gtggaggttt gctacagaag ttaacaagag atctcttgaa ttgttccttc     1140

aagtgtagct atgttgtaac taatggcctt gggattaacg tcttcaagga cccggttgct     1200

gatcccaaca aaaggtccaa aaagggccga ttatctttac ataggacgcc agcagggaat     1260

tttgttacac tggaagaagg aaaaggagac cttgaggaat atggtcagga tcttctccat     1320

actgtcttca agaatggcaa ggtgacaaaa agctattcat ttgatgaaat aagaaaaaat     1380

gcacagctga atattgaact ggaagcagca catcattagg ctttatgact gggtgtgtgt     1440

tgtgtgtgtg tgtgtgcatg cacacacaca cacacctttg tgtatgtaat acataatgtt     1500

tattgtacag atgtgtgggg tttgtgtttt atgacacatt acagccaaat tatttgttgg     1560

tttatggaca tactgccctt tcattttttt tcttttccag tgtttaggtg atctcaaatt     1620

aggaaatgca tttaactatg taaaagatta gtgctaaagt aagcttttta gggccctttg     1680

ccaataggta gtcattcaat ctggtattga tcttttcaca aataacagaa ctgagaaact     1740

tttatatata actgatgatc acataaaaca gatttgcata aaattaccat gattgcttta     1800

tgtttatatt taacttgtat ttttgtacaa acaagattgt gtaagatata tttgaagttt     1860

cagtgattta acagtctttc caacttttca tgatttttat gagcacagac tttcaagaaa     1920

atacttgaaa ataaattaca ttgccttttg tccattaatc agcaaataaa acatggcctt     1980

aacaaagttg tttgtgttat tgcacaattt gaaaattatg tcgggacata ccctatagaa     2040

ttactaacct tactgcccct tgtagaatat gtattaatca ttctacatta aagaaaataa     2100

tggttcttac tggaatgtct aggcactgta cagttattat atgtcttggt tgttgtattg     2160

taccagtgaa atgccaaatt tgaaaggcct gtactgcaat tttatatgtc agagattgcc     2220

tgtggctcta atatgcacct caagatttta aggagataat gtttttagag agaatttctg     2280

cttccactat agaatatata cataaatgta aaatacttac aaaagtggaa gtagtgtatt     2340

ttaaagtaat tacacttctg aatttatttt tcatattcta tagttggcat gacttaaatg     2400

aattactgga gtgggtagtg agtgtactta tcttaaatgt ttcaattctg ttatattttt     2460

tattaagttt tttaaaaatt aaattgatat taaattgtaa aaaaaaaaaa aaaa           2514


<210> 3303
<211> 541
<212> DNA
<213> Homo sapiens

<400> 3303
tgtaagcaat ctacgaagac cgaggaaaag ctgcggccta ccaggacatc ctcggaaagt       60

atttattcta ggccaggctc cagtattcct ggctcaccag gtcatactat ctatgcaaaa      120

gtagacaatg agatcctgga ttacaaggat ttagcagcca ttccgaaggt caaggcaatt      180

tatgacattg aacgtccaga tcttattacc tatgagcctt tctacacttc gggctatgat      240

gacaaacagg agagacagag ccttggagag tctccgagga ctttgtctcc tactccatca      300

gcagaagggt accaggatgt tcgggatcgg atgatccatc ggtccacgag ccagggctcc      360

atcaactccc ctgtgtacag ccgccacagc tacactccaa ccacgtcccg ctctccccag      420

catttccaca gacctgatca aggaatcaac atttaccgaa agccacccat ctacaaacag      480

catgtactgt ttgaagtcat ccttttgttg ttaatttaag aataaaattc tcagcatttg      540

a                                                                      541


<210> 3304
<211> 2445
<212> DNA
<213> Homo sapiens

<400> 3304
atgaggctcc tggatgggaa acagacttcc aggtactcag agaatgcctg cgagaagaag       60

attttctcta tctacggaca ctacccggtg gtccgggccg ctctgcgaag gaagggctgg      120

gtagagaaga agttccactt tttgcccaag gtcattccgg atgtcgagga tgaaggcgcc      180

cgggtcaatg atgatacatg tgccaaagtc aaagaaaatc aagaaatggc tttggagaaa      240

acagacaaca tccacgacgt gatgtctagg ttggtaaaaa atgagatgcc gtacctcctc      300

tggaccatca agagggacat cattgactat cacagcctga cctacgacca gatgctgaac      360

cactacgcaa agacagcctc cttcaccacc aagatcgggc tgtgcgtgaa catgcggagc      420

ctgccctggt acgtcccggc caaccccgac tccttcttcc cacgctgcta cagcctctgc      480

accgagagtg agcagcagga gttcctggaa gacttccggc gcaccatggc atccagcatc      540

ctcaagtggg tggtcagcca ccagagctgc agcaggagca gcagaagcaa gcccagggac      600

cagagggagg aggccgggag cagcgacctg agcagcaggc aagatgctga aaatgctgag      660

gcaaagctca ggggcctccc ggggcagctt gtggacatcg cgtgcaaggt gtgccaggcc      720

tacctggggc agctggagca tgaggacatc gacacgtcag cagatgccgt ggaggacctc      780

actgaggccg agtgggagga cctgacccag cagtactact ccctcgttca tggcgatgct      840

ttcatctcca attcaagaaa ttacttttcg cagtgccagg ctctgctgaa tagaatcacg      900

tctgtgaacc ctcagacgga cattgacggg ctccggaaca tctggattat aaagcccgcg      960

gccaagtccc ggggccgaga catagtgtgc atggaccgtg tggaggagat cctggagctg     1020

gcagctgcag accaccctct ttccagggac aacaagtggg tggtccagaa gtacatcgag     1080

acgccgctgc tcatctgtga caccaagttc gacatcagac agtggttcct cgtcacggac     1140

tggaaccccc tgaccatctg gttctacaag gagagttact tgcggttctc aactcagcgc     1200

ttctccctgg acaagctgga cagcgccatc cacctgtgca acaacgccgt ccagaagtac     1260

ctgaagaatg atgtgggccg cagccccctg ctgcccgcac acaacatgtg gaccagcacc     1320

aggttccagg agtacctgca gcgccagggc cgtggcgccg tgtggggcag cgtcatctac     1380

ccgtccatga agaaggccat cgcccacgcc atgaaggtgg cccaggacca cgtggagcct     1440

cgcaagaaca gctttgagct ctacggggct gacttcgtcc ttgggaggga cttcaggccc     1500

tggctgatcg agatcaattc cagccccacc atgcacccgt ccacgccggt cacggcccag     1560

ctgtgtgcac aggtgcagga ggacaccatc aaggtggccg tggaccgcag ctgtgacatc     1620

ggcaacttcg agctcctgtg gaggcagccg gtggttgagc cgcccccatt cagcgggtcc     1680

gacctctgcg tggcgggcgt cagtgtgagg agagccagga ggcaggtgct gcccgtctgc     1740

aacctcaagg cctcggcctc gctgttggac gcgcagccgc tgaaggcacg gggcccctcg     1800

gccatgccag accctgccca gggaccccca tcaccagctc tccagcggga cttgggactg     1860

aaggaagaga aggggctccc cctggccttg ctggcaccct taaggggggc agccgagagc     1920

ggtggagccg cacagcccac ccgcaccaaa gctgctggga aggtggagct cccggcctgc     1980

ccctgtcgcc acgtggacag tcaggcccca aacaccggtg tccccgtagc ccagcccgcc     2040

aaaagctggg atccaaacca gctaaatgcg cacccgctgg agcctgtgct gcggggcctg     2100

aagacagcag agggcgcgct gcgtccgccg cccggaggaa aaggagaggg cacggtctgc     2160

agccgcctgc cacaccacgg gcaccacgtg gccgcctgcc agaccacggg caccacgtgg     2220

gatggtgggc ctggggtgtg cttcctccgg cagctcctgg catcagaact gcccatgggc     2280

cctgggctgc cgagggaccc ccgagcgccg ccctgcctcg tgtgccgcgg gctgctgcca     2340

cccgccgggc cctgcaagcg ctgccgctcg ttctgcgccg cggtcctgca gggcgcgtcc     2400

ttcgtgcggc tcggcgggcg gagctgcagc ccgcggaccc cgtga                     2445


<210> 3305
<211> 550
<212> DNA
<213> Homo sapiens

<400> 3305
aagagccctg ggctgggtgg ggcagggcgg aagggccctg gccttgttgg gtggaggtga       60

agagttaatg gctccgcgcg caggcactgc cctctgaact ggaacaaaat gcaacttccg      120

gttggagtca ctcggccagg cgccggcgac ctgaggggag agggaacgca gctgaaagcg      180

tgaactacct gtcatttact ccatccttta tagtgatgct acaggacgaa gaggaatgga      240

taaaaacatt ggcgagcaac tcaataaagc gtatgaagcc ttccggcagg catgcatgga      300

tagagattct gcagtaaaag aattacagca aaagactgag aactatgagc agagaatacg      360

tgaacaacag gaacagctgt cacttcaaca gactattatt gacaagctaa aatctcagtt      420

acttcttgtg aattccactc aagataacaa ttatggctgt gttcctctgc ttgaagacag      480

tgaaacaaga aagaataatt tgactcttga tcagccacaa gataaagtga tttcaggaat      540

agcaagagaa                                                             550


<210> 3306
<211> 1145
<212> DNA
<213> Homo sapiens

<400> 3306
aagatggcgc cggtgggggt ggagaagaag ctgctgctag gtcccaacgg gcccgcggtg       60

gcggccgccg gcgacctgac cagtgaggag gaggaaggcc agagcctatg gtcctccatt      120

ctgagcgaag tgtccacccg cgccaggtcc aagctgccgt ccggcaagaa catcctggtc      180

ttcgatcaca cgcgctgcaa cgtgtggatt ctggatggag acttgtacca caaaggcctg      240

ctgaaatttg cagtttctgc tgaatccttg ccagagaccc tcgtcatttt tgttgcagac      300

atgtctagac cttggactgt gatggaatct ctgcagaaat gggctagtgt tttacgtgag      360

cacattgata aaatgaaaat tccaccagaa aaaatgaggg agctggaacg gaagtttgtg      420

aaagattttc aagactatat ggaacctgaa gaaggttgtc aaggttcccc acagagaaga      480

ggccctctga cctcaggctc cgatgaagaa aatgttgccc tgcctctggg tgacaatgtg      540

ctgactcata acctggggat cccggtgttg gtggtgtgca caaagtgtga tgcggtgagt      600

gtcctggaga aggagcacga ttacagggat gagcatttgg actttatcca gtcacacctg      660

cggaggttct gccttcagta tggagctgcc ttgatttaca catcagtgaa agaagagaaa      720

aacctcgact tgttgtataa gtatattgtt cataaaacat acggtttcca cttcaccaca      780

cctgccttag ttgtggaaaa ggatgccgtt tttatgtgag ttattttgag ctgatgcttt      840

gaaactcttc tttttaaagt acatttgctt tttacatttt accccttcaa ggaaggtgcc      900

ttctgtctgt gtcttctaca gccagctctc tcactgcacc ttctctctgt tcctttccgg      960

attatgaggc atctgcctga gggaagtggg tggtgtggtc aggggtgctg cctttcttcc     1020

tcgagagcaa gttgccaaaa cctaagccag ccatttttgg cactcactgt caactctggt     1080

aaaatactgg ctggggaggg aatataggga attgtgcttg ggggatcctg aatgtcttct     1140

attaa                                                                 1145


<210> 3307
<211> 724
<212> DNA
<213> Homo sapiens

<400> 3307
tgggagtgtg gctctgtgcg tgcgtgatga gtgccagata gattcgcgga agaaattggg       60

tggctgtgtg ctggcgtgtg attgtgcgcg ccggacatgg ccatgtgagt tggttcattc      120

ttggtccggt gccccttctg ttgggtaaaa cttggatctg gcccgagaat acttcagaga      180

gtcagagttg tgccagaagt ctcttaatgg cagatagaat gcaaatagtt gtgattctct      240

cagaattttt taataccaca tggcaggagg caaattgtgc aaattgttta acaaacaaca      300

gtgaagaatt atcaaacagc acagtatatt tccttaatct atttaatcac accctgacct      360

gctttgaaca taaccttcag gggaatgcac atagtctttt acagacaaaa aattattcag      420

aagtatgcaa aaactgccgt gaagcataca aaactctgag tagtctgtac agtgaaatgc      480

aaaaaatgaa tgaacttgag aataaggctg aacctggaac acatttatgc attgatgtgg      540

aagatgcaat gaacatcact cgaaaactat ggagtcgaac tttcaactgt tcagtccctt      600

gcagtgacac agtgcctgta attgctgttt ctgtgttcat tctctttcta cctgttgtct      660

tctaccttag tagctttctt cactcagagc aaaagaaacg caaactcatt ctgcccaaac      720

gtct                                                                   724


<210> 3308
<211> 685
<212> DNA
<213> Homo sapiens

<400> 3308
gtttattcat tgtactgatg attctccaga tccatgtata gaatatgagc tcgttctccg       60

aaaatggtgt gaattgattc ctggggctga gtttcgatgt tttgtcaagg aaaacaagct      120

tattggtatt tctcaaagag actacacaca atactatgat catatttcta aacaaaagga      180

agaaattcgc agatgcatac aagacttttt caagaaacac atacagtaca aattcttaga      240

tgaagacttt gtgttcgata tatacagaga cagtaggggg aaggtgtggc tcattgactt      300

taatccattt ggtgaagtca cagattcact gctgttcacc tgggaagaac tgatatctga      360

gaacaactta aacggcgatt ttagtgaagt tgacgctcaa gagcagaaga gaaatcagca      420

ggaggacgac tgatgagcgt actggaactg gagaagagga ggccccgccc caccgctccg      480

ggagctgctc atcagccgca acttcctgcc gaccctgatg cgggtgggcc gagcagtgtg      540

gacatcagcc actttttata ttcatgtaca ttcacctggg gaaaaaaacg gagggacttt      600

gctacttgta aaaataacat aataaataga tcttaaacat aggaaaacca tactgttctg      660

ataataaaat gctttctatg aaata                                            685


<210> 3309
<211> 976
<212> DNA
<213> Homo sapiens

<400> 3309
atatccaagg ggaggcgtcc aggagggctg ctggagagcc agaggctggc agcgactatg       60

tgaagttctc caaggagaag tacatcctgg actcatcgcc agagaaactc cacaaggaat      120

tggaggagga gctcaaactc agcagcacgg atctccgcag ccatgcctgg taccatggcc      180

gcatcccccg agaggtctcg gagaccttgg tacaacgcaa cggcgacttc ctcatccggg      240

actcactcac cagcctgggc gactatgtgc tcacgtgccg ctggcgcaac caggccttgc      300

acttcaagat caacaaggtg gtggtgaagg caggcgagag ctacacacac atccagtacc      360

tgtttgagca ggagagcttt gaccacgtgc ccgccctcgt gcgctatcat gtgggcagcc      420

gcaaggctgt gtcagagcag agtggtgcca tcatctactg cccggtgaac cgcaccttcc      480

cactgcgcta cctcgaggcc agctatggcc tgggacaggg gagtagcaag cctgctagcc      540

ccgtcagccc ctcaggcccc aagggcagcc acatgaagcg gcgcagcgtc accatgaccg      600

atgggctcac tgctgacaag gtcacccgca gcgatggctg ccccaccagt acgtcgctgc      660

cccgccctcg ggactccatc cgcagctgtg ccctcagcat ggaccagatc ccagacctgc      720

actcacccat gtcgcccatc tccgagagcc ctagctcccc tgcctacagc actgtaaccc      780

gtgtccatgc cgcccctgca gccccttctg ccacagcatt gcctgcctcc cctgtcgccc      840

gccgttccag tgagccccag ctgtgtcccg gaagtgcccc aaagacccat ggggagtcag      900

acaagggccc ccacaccagc ccctcccaca cccttggcaa ggcctccccg tcaccatcac      960

tcagcagcta cagtga                                                      976


<210> 3310
<211> 501
<212> DNA
<213> Homo sapiens

<400> 3310
gcaaacgggg ccggaaagcg tggcagcgca ggcgcaagcg cagagagcgg aggcggtggt       60

ggtggcggcc gctggccagt tgaatctaca gacctatttt ctcaggagct cagcctggcc      120

ttacttcagt gataaaagga ggaaaggctg gctacagcaa acatcattca agatgtccag      180

caaagggagc agcacagatg gcagaacaga cttagctaat ggaagcctgt ctagcagtcc      240

agaggagatg tctggagctg aagaggggag ggagacatcc tcaggcattg aagtggaggc      300

ctcagacctg agtttgagct tgactgggga tgatggtggc cccaaccgca ccagcacaga      360

aagtcgaggc acagacacag agagctcagg tgaagataag gactctgaca gcatggagga      420

cactggtcat tactccatta atgatgaaaa tcgagtccat gaccgctcag aggaagagga      480

agaggaggaa gaagaggagg a                                                501


<210> 3311
<211> 1780
<212> DNA
<213> Homo sapiens

<400> 3311
gctgctggtg ctcctcgcct cttggggcct ggggcagtga gggggccggc gggcgtgggc       60

cgagtggccg cgggcgccat ggagggggtg ctgtacaagt ggaccaacta tctgagcggt      120

tggcagcctc gatggttcct tctctgtggg ggaatattgt cctattatga ttctcctgaa      180

gatgcctgga aaggttgcaa agggagcata caaatggcag tctgtgaaat tcaagttcat      240

tctgtagata atacacgcat ggacctgata atccctgggg aacagtattt ctacctgaag      300

gccagaagtg tggctgaaag acagcggtgg ctggtggccc tgggatcagc caaggcttgc      360

ctgactgaca gtaggaccca gaaggagaaa gagtttgctg aaaacactga aaacttgaaa      420

accaaaatgt cagaactaag actctactgt gacctccttg ttcagcaagt agataaaaca      480

aaagaagtga ccacaactgg tgtgtccaat tctgaggagg gaattgatgt gggaactttg      540

ctgaaatcaa cctgtaatac ttttctgaag accttggaag aatgcatgca gatcgcaaat      600

gcagccttca cctctgagct gctctaccgc actccaccag gatcacctca gctggccatg      660

ctcaagtcca gcaagatgaa acatcctatt ataccaattc ataattcatt ggaaaggcaa      720

atggagttga gcacttgtga aaatggatct ttaaatatgg aaataaatgg tgaggaagaa      780

atcctaatga aaaataagaa ttccttatat ttgaaatctg cagagataga ctgcagcata      840

tcaagtgagg aaaatacaga tgataatata acagtccaag gtgaaataag gaaggaagat      900

ggaatggaaa acctgaaaaa tcatgacaat aacttgactc agtctggatc agactcaagt      960

tgctctccgg aatgcctctg ggaggaaggc aaagaagtta tcccaacttt ctttagtacc     1020

atgaacacaa gctttagtga cattgaactt ctggaagaca gtggcattcc cacagaagca     1080

ttcttggcat catgttatgc tgtggttcca gtattagaca aacttggccc tacagtgttt     1140

gctcctgtta agatggatct tgttggaaat attaagaaag taaatcagaa gtatataacc     1200

aacaaagaag agtttaccac tctccagaag atagtgctgc acgaagtgga ggcggatgta     1260

gcccaggtta ggaactcagc gactgaagcc ctcttgtggc tgaagagagg tctcaaattt     1320

ttgaagggat ttttgacaga agtgaaaaat ggggagaagg atatccagac agccctaaat     1380

aatgcatatg gtaaaacatt gcggcaacac catggctggg tagttcgagg ggtttttgcg     1440

ttagctttaa gggcagctcc atcctatgaa gattttgtgg ccgcgttaac cgtaaaggaa     1500

ggtgaccacc agaaagaagc tttcagtatt gggatgcaga gggacctcag cctttacctc     1560

cctgccatgg agaagcagct ggccatactg gacactttat atgaggtcca cgggctggaa     1620

tctgatgagg tggtatgatg gctgctgggc agcacctcct aacttcaggg aataagtgct     1680

aaagtgtttt gttgccctac ttaatttcca gcaacagcct caaccctctc caaccccttc     1740

acctgggggg atggacagga ggtggcaaaa cccagtgctt                           1780


<210> 3312
<211> 2614
<212> DNA
<213> Homo sapiens

<400> 3312
ggaggccgct gggacgcggt tcagctcatt ccctgaggcc ggcccgcgtc ccgtcaggcg       60

ccgcgcgggg ttagcgcggg gtcagcggag gtcagcgggg gtcagcagca gcggctccga      120

gggcgcggcg gacgcaggat gtacacgctg ctgtcgggct tgtacaagta catgtttcag      180

aaggacgagt actgcatcct gatcctgggc ctggacaatg ctgggaagac gaccttcctg      240

gagcagtcga aaacccgatt taacaagaac tacaagggga tgagtctatc caaaatcacc      300

accaccgtgg gcctaaacat cggcactgtg gatgtgggaa aggctcggct catgttctgg      360

gacttaggag ggcaggaaga gctgcagtct ttgtgggaca agtattatgc ggagtgtcac      420

ggcgtcatct acgtcattga ctccaccgac gaggagaggc tggctgagtc caagcaggcg      480

tttgagaagg tggtgaccag cgaggcgctg tgcggtgtcc ccgtcttggt gctggccaac      540

aagcaggatg tggagacgtg cctctcaatc cctgacatca agacggcctt cagcgactgc      600

accagcaaga tcggcaggcg agattgcctg acccaggcct gctcggccct cacagggtga      660

gtgggggctg cacctgcggg ggctttgggg accgagaccc cccgcctcac acccgctgtc      720

ttcacagcaa aggggtgcgc gagggcatcg agtggatggt gaagtgtgtc gtgcggaatg      780

tgcaccggcc gccgcggcag agggacatca cgtaggcgca gccgcgctgc cgtcgggacg      840

gctggtcccc tggtgctgga ggagtggcct cctgttggct cccatgctgc tgatctgggg      900

ggtgggtttg ctttgctttg gggttcttct atttactttg ttttctcgaa gacaaacttt      960

cctctatgtc tggaaaagcg taggcatccg gaggctttgg aggggagtct ggcagcccgg     1020

ctggcccagg ccctgcagcg gcagcctttc cacagggcgc agcggcggcc tttcgaggcc     1080

ctttctgggg ggtctgaggg agacctggtt gggaattggg gctccagtgc tcaggctggc     1140

ttgggctgca tgaggacagc cctgtgggac cctcgggaga ccccgtggct gtctccgccc     1200

catcgaggag gaggcccgtc agccatggct gccatctggc ttctgccctg tgaccccgtg     1260

accccgtgac cccgaagtgg tctggggctg atcttgcctt gaggaagacc caggccatgt     1320

tcccaaaggc cagcgggggc cctggattgt gatgcagcct cgggacaggg ctgaggcctg     1380

cgggggaaga cctatacccc acgcctgggc ctggcttcac ctcaccctaa tcccccggga     1440

gggagctgac tgatgcaaaa agctgagggg gcctgctggg agtggctgtt tttatgcccc     1500

agccccgcaa gttggggagt gtttgtgggg gtccagagcc ctcccccagc caggagagaa     1560

cctcccggag gggttctctg tggggccctg tgtcccctgc tcgggagtaa ggctggtcct     1620

ggggtcctcc ctgcacggac cccactgggc ctgccgagtg ctgtgttctt cctcagtctg     1680

gctgtgggca ggagcggcct gcccagtgtc acccagggtg agtgcaaaat aaagacggcg     1740

agtgtggctc tgtccatccc ttccctcctg gagggtggag gctcctggct gttggacacg     1800

gtgatggtgt tactgggctg ctcaggggct ggtgggcagg tgaggggctc cccaggtggg     1860

cctggagagt ccaggcactc ccttcctgcg gatgtgggaa ggacatgggg tcctgggagg     1920

agctgctggg aaggggcatg agtcagggtg ggggtggcgc agcagctgcg gggctgtgac     1980

tcacaggagt cgggccctgg aagtccccgc gtcctctcca ggggaccctg tgtgtgttct     2040

gcaggttggt tcccaggacc tgggggggac ctccagcccc gggaacctgg ccgtgctggg     2100

gaggcgagtg gctggtgcag ccccccggtt gctctgggtg catcgggagg cttcagagcc     2160

tgccccagag agggagaagc ttcacttccc ggaaagcatg ggaggcctgg aggaggtctt     2220

tggcaggtcc cctctcggga aatcccctgt gagttgggag tgggaggaat tcataagtgg     2280

ggggttagtg tgggccccgg cgactagggc tggcctgagc cccatcctgt tcttccagca     2340

atgataccct cccaggccct gaccctcgct gagcttcagg ggcccctgcc acgtgccaca     2400

gccactgggg gcagaggtgg cactccccac tgatcctccc agggagggtc tgtctgaggt     2460

aggggaagcc ccgggcagca gttctgatgg caggcagcct gagggatctg ggcacagcgg     2520

gcggctcagg tgtccccggc tgccctccca gtagctgtgc aactacaacc agttttatga     2580

aaaagcttta taaaaataag ctttaagaaa cctc                                 2614


<210> 3313
<211> 1067
<212> DNA
<213> Homo sapiens

<400> 3313
agtacaatgc ggccgcgggg agcgcgggcc cgcgggggag gggagcgccg ccgcgccggg       60

ctcggcccct ccccctctct gcgctctctt cgggatacac gtgggcttcg ggcctgggcc      120

gcgcagtttt tctttggctt tctcgaatca tcgaggagac tggcaaaatt agtaatgtct      180

ttagactgcg tcactagcgc caatcgaatt cgtagttgat tgttctttga attcacattt      240

gagtcctcgg ttaaaacctc agttaaaaag caggataaag tcgagctgct ttggttctcg      300

gaacggaaaa gcgttttttt gttgtttaga ggcttggcct ttatggggct cgtgtgtgtt      360

ttaggggacg gcaaaacaga acagaaaggc ggagataaaa agaggggtgt taaaagacca      420

cgagaagatc atggccgtgg atattttgag tacattgaag agaacaagta tagcagagcc      480

aaatctcctc agccacctgt tgaagaagaa gatgaacact tcgatgacac agtggtttgt      540

cttgatactt ataattgtga tctacatttt aaaatatcaa gagatcgtct cagtgcttct      600

tcccttacaa tggagagttt tgcttttctt tgggctggag gaagagcatc ctatggtgtg      660

tcaaaaggca aagtgtgttt tgagatgaag gttacagaga agatcccagt aaggcattta      720

tatacaaaag atattgacat acatgaagtt cgtattggct ggtcactaac tacaagtgga      780

atgttacttg gtgaagaaga attttcttat gggtattctc taaaaggaat aaaaacatgc      840

aactgtgaga ctgaagatta tggagaaaag tttgatgaaa atgatgtgat tacatgtttt      900

gctaactttg aaagtgatga agtagaactc tcgtatgcta agaatggaca agatcttggc      960

gttgccttca aaatcagtaa ggaagttctt gctggacggc cactgttccc gcatgttctc     1020

tgccacaact gtgcagttga atttaatttt ggtcagaagg aaaagcc                   1067


<210> 3314
<211> 2920
<212> DNA
<213> Homo sapiens

<400> 3314
agctcctctg acaaggagtc catcctgacc atcctcaagg tcctcggaga tctgctttct       60

gttggcacag accggagaat tcactacatg atcagcaagg gtggcagtga agctcttctg      120

cagaccctgg tagacacagc gaggacagct cctccagact atgacatcct cctgcctctc      180

ttccggctgc tggccaaagt tggcctaaga gataaaaaga ttggacggaa ggccctagaa      240

ttggaagcac ttgatgtgac attgattctg gccaggaaga acctatccca tggccagaat      300

ctcctccact gtctctgggc tctgcgtgtg tttgcctcca gtgtctccat gggagccatg      360

ctgggaatta atggagccat ggaactgctt ttcaaggtta ttactcctta cacccgaaag      420

cgcacccaag caatcagggc agccactgaa gttttggcag cattgctgaa atccaagtcg      480

aacggccgca gagcagtgaa ccgaggctac gtcaccagcc tgctcgggct gcaccaggac      540

tggcacagcc atgacacagc caacgcctac gtgcagatcc gacggggctt gctgctctgc      600

ctcaggcaca ttgctgccct ccggtccggc agggaggcct tcctggcagc acagggcatg      660

gagatcctct tcagcaccac acagaactgc ctggatgaca agagcatgga gcccgtcatc      720

tctgtggtgc ttcagatcct gaggcagtgc taccctacga gtccacttcc cttggtcaca      780

gccagcagtg cctatgcctt cccggtcccc gggtgcatca ccactgaacc tccacatgat      840

ctacctgaag aggattttga agatgatggc gatgatgaag tggacaaaga ctctgatact      900

gaagatggga aagtggaaga tgatgacttg gaaacagacg tgaacaagct gagttccaaa      960

cctggtcttg accgacctga agaggaactg atgcaatatg aggtgatgtg tcttgagctc     1020

tcctatagct ttgaggaact gcagtccaaa cttggagatg atttgaactc tgaaaagact     1080

cagtatgcca atcaccacca cattccagcc gctgcctcct caaaacagca ttgctacagc     1140

aaggaccaaa gctcctgtgg gcaagaaaga gaatatgctg tccagacttc ccttctgtgc     1200

agggtgaaga cgggaaggtc cactgtgcat ctaggctcca aaaaaaatcc tggagtgaac     1260

ctgtaccaaa atgtgcaatc caatagtctc aggagagatt cttctgaaag tgaaatccct     1320

gacattcagg cttccccgaa agcagatgcc tgggacgtag atgcaatttt ctgcccaagg     1380

atgagtgcct ccttttctaa ttccactagg actagagaag ttgtcaaagt aatagataag     1440

cttctgcaga cacatctgaa gcgtgtccct ttccacgatc cctatcttta tatggccaaa     1500

gccagaagaa ccagctctgt ggtggacttc aagatgatgg catttcctga tgtctgggga     1560

cactgtcccc ctcccaccac ccagcctatg ttggaacgaa aatgtggagt ccaaaggatc     1620

aggatatttg aggatattcg gaggctcatc cagccaagtg atgttataaa taaagttgtc     1680

ttcagtttag atgagccttg gcctttgcaa gacaatgctt ccaattgttt acggttcttc     1740

tccaaatttg agtcaggaaa tcttcgcaaa gccatccaag tgcgtgagtt cgagtatgac     1800

ttgctggtca acgcagatgt gaatagcacc cagcaccagc agtggttcta tttcaaagtg     1860

agcggtatgc aggcggccat cccttaccac ttcaacatca tcaactgtga gaagcccaac     1920

agccagttta attatgggat gcagcccacc ctatattctg tgaaggaggc tcttcttggc     1980

aaacccacct ggataaggac aggccatgaa atatgttatt acaaaaatca ttatcgccag     2040

agtacagctg ttgcaggcgg agcatctggg aagtgctact ataccctcac ctttgctgtc     2100

accttcccac acagtgagga tgtctgctac ctggcctacc actatcccta tacctacaca     2160

gccctcatga ctcatcttga catcctggaa aagagtgtca acctcaaaga ggtctacttc     2220

cggcaagatg ttctctgcca gacgctggga gggaatccgt gtcccttggt gaccatcacg     2280

gccatgcctg agtccaacag tgatgagcat ctagagcagt tccgacatcg tccatatcag     2340

gtgatcactg ctcgagttca tccaggagag agcaatgcca gttgggtgat gaagggtacc     2400

ttggagttcc tggtcagcag tgaccctgtg gctaggctct tgagggaaaa cttcatcttc     2460

aagatcatac ccatgctcaa cccagatggt gtcatcaacg gcaaccacag atgctcactg     2520

agcggggaag atttgaacag acaatggctt tctcccagtg ctcatctgca gccaaccatt     2580

taccatgcca aaggcctcct ctaccacctg agcagcattg gccgaagtcc cgtggtgagt     2640

cacttccttc tggttttctg tgacttccat ggccactccc aaaagaagaa tgtgttcctt     2700

tatggctgta gcatcaagga aaccttgtgg caagcagcat gcactgtggg cacatctact     2760

atcctagagg aggtcaacta caggactctt cccaaaatcc ttgataagct agcaccagca     2820

ttcacaatga gcagctgcag ctttctcgtg gagaaatctc gagcttccac ggcccgggtg     2880

gtggtgtgga gagagatggg ggtgtccaga agctacacca                           2920


<210> 3315
<211> 7829
<212> DNA
<213> Homo sapiens

<400> 3315
ctccagcatc accttctctg tgaaggtaga aggacgcccg gtgcccaccg tgcactggct       60

cagggaggag gctgagagag gcgtgctgtg gattggccct gacacaccgg gctacaccgt      120

ggccagctct gcgcagcagc acagcctggt cctgctggac gtgggccggc agcaccaggg      180

cacctacaca tgcattgcca gcaacgctgc cggccaggcc ctctgctccg ccagcctgca      240

cgtctcgggc ctgcctaagg tggaggagca ggagaaagtg aaggaagcgc tgatttccac      300

tttcctgcag gggaccacac aagccatctc agcacagggg ttggaaactg cgagttttgc      360

tgaccttggt gggcagagga aagaagagcc tctggctgcc aaggaggccc tcggccacct      420

gtccctcgct gaggtgggca cagaggagtt cctgcagaaa ctgacctccc agatcactga      480

gatggtatcg gccaagatca cgcaggccaa gctgcaggtg cccggaggtg acagtgatga      540

ggactccaag acaccatctg catccccccg ccatggccga tcacggccat cctccagcat      600

ccaggagtct tcctcagagt cagaggacgg cgatgcccga ggcgagatct ttgacatcta      660

cgtggtcacc gctgactacc tgcccctagg ggctgagcag gatgccatca cgctgcggga      720

aggccagtat gtggaggtcc tggatgcagc ccacccactg cgctggcttg tccgcaccaa      780

gcccaccaag tccagcccct cacggcaggg ctgggtgtca ccagcctacc tggacaggag      840

gctcaagctg tcacctgagt ggggggccgc tgaggcccct gagttccctg gggaggctgt      900

gtctgaagac gaatacaagg caaggctgag ctctgtgatc caggagctgc tgagttctga      960

gcaggccttc gtggaggagc tgcagttcct gcagagccac cacctgcagc acctggagcg     1020

ctgcccccac gtgcccatag ctgtggccgg ccagaaggca gtcatcttcc gcaatgtgcg     1080

ggacatcggc cgcttccaca gcagcagctt cctgcaggag ttgcagcagt gcgacacgga     1140

cgacgacgtg gccatgtgct tcatcaagaa ccaggcggcc tttgagcagt acctggagtt     1200

cctggtgggg cgtgtgcagg ctgagtcggt ggtcgtcagc acggccatcc aggagttcta     1260

caagaaatac gcggaggagg ccctgttggc aggggacccc tctcagcccc cgccaccacc     1320

tctgcagcac tacctggagc agccagtgga gcgggtgcag cgctaccagg ccttgctgaa     1380

ggagctgatc cgcaacaagg cgcggaacag acagaactgc gcgctgctgg agcaggccta     1440

tgccgtggtg tctgccctgc cacagcgcgc tgagaacaag ctgcacgtgt ccctcatgga     1500

gaactaccca ggcaccctgc aggccctggg cgagcccatc cgccagggcc acttcatcgt     1560

gtgggagggt gcaccggggg cccgcatgcc ctggaagggc cacaaccgtc acgtgttcct     1620

cttccgcaac cacctggtaa tctgcaagcc ccggcgagac tcccgcaccg ataccgtcag     1680

ctacgtgttc cggaacatga tgaagctgag cagcatcgac ctgaacgacc aggtggaggg     1740

ggatgaccgc gccttcgagg tgtggcagga gcgggaggac tcggtgcgca agtacctgct     1800

gcaggcacgg acagccatta tcaagagctc gtgggtgaag gagatctgtg gcatccagca     1860

gcgtctggcc ctgcctgtgt ggcggccccc ggactttgaa gaggagctgg ccgactgcac     1920

agccgagctg ggtgagacag tcaagctggc ctgccgcgtg acgggcacac ccaagcctgt     1980

catcagctgg tacaaagatg ggaaagcagt gcaggtggac ccccaccaca tcctcattga     2040

agaccctgat ggctcgtgtg cactcatcct ggacagcctg accggtgtgg actctggcca     2100

gtacatgtgc ttcgcggcca gcgccgctgg caactgcagt accctgggca agatcctggt     2160

gcaagtccca ccacggttcg tgaacaaggt ccgggcctca ccctttgtgg agggagagga     2220

cgcccagttc acctgcacca tcgaaggcgc cccgtacccg cagatcaggt ggtacaagga     2280

cggggccctg ctgaccactg gcaacaagtt ccagacactg agtgagcctc gcagcggcct     2340

gctagtgctg gtgatccggg cggccagcaa ggaggacctg gggctctacg agtgtgagct     2400

ggtgaaccgg ctgggctccg cgcgggctag tgcggagctg cgcattcaga gccccatgct     2460

gcaggcccag gagcagtgtc acagggagca gctcgtggct gcagtggaag acaccaccct     2520

ggagcgagcg gaccaggagg tcacatctgt cctgaagaga ctgctgggcc ccaaggcgcc     2580

aggcccctcc acaggggacc tcactggccc tggcccctgc cccagggggg cacccgcact     2640

ccaggaaacc ggctcccagc ccccagtcac cggaacttcg gaggcacctg ccgtgccccc     2700

gagggtgcca cagcccctcc tccacgaagg cccagagcag gagccggagg ccattgccag     2760

agcccaggaa tggactgtgc ccattcggat ggagggtgca gcctggcccg gggcaggcac     2820

aggggagctg ctctgggacg tccacagcca cgtggtcaga gagaccacac agaggaccta     2880

cacataccag gccatcgaca cgcacaccgc acggccccca tccatgcagg taaccatcga     2940

ggatgtgcag gcacagacag gcggaacggc ccaattcgag gctatcattg agggcgaccc     3000

acagccctcg gtgacctggt acaaggacag cgtccagctg gtggacagca cccggcttag     3060

ccagcagcaa gaaggcacca catactccct ggtgctgagg catgtggcct cgaaggatgc     3120

cggcgtttac acctgcctgg cccaaaacac tggtggccag gtgctctgca aggcagagct     3180

gctggtgctt gggggggaca atgagccgga ctcagagaag caaagccacc ggaggaagct     3240

gcactccttc tatgaggtca aggaggagat tggaaggggc gtgtttggct tcgtaaaaag     3300

agtgcagcac aaaggaaaca agatcttgtg cgctgccaag ttcatccccc tacggagcag     3360

aactcgggcc caggcataca gggagcgaga catcctggcc gcgctgagcc acccgctggt     3420

cacggggctg ctggaccagt ttgagacccg caagaccctc atcctcatcc tggagctgtg     3480

ctcatccgag gagctgctgg accgcctgta caggaagggc gtggtgacgg aggccgaggt     3540

caaggtctac atccagcagc tggtggaggg gctgcactac ctgcacagcc atggcgttct     3600

ccacctggac ataaagccct ctaacatcct gatggtgcat cctgcccggg aagacattaa     3660

aatctgcgac tttggctttg cccagaacat caccccagca gagctgcagt tcagccagta     3720

cggctcccct gagttcgtct cccccgagat catccagcag aaccctgtga gcgaagcctc     3780

cgacatttgg gccatgggtg tcatctccta cctcagcctg acctgctcat ccccatttgc     3840

cggcgagagt gaccgtgcca ccctcctgaa cgtcctggag gggcgcgtgt catggagcag     3900

ccccatggct gcccacctca gcgaagacgc caaagacttc atcaaggcta cgctgcagag     3960

agcccctcag gcccggccta gtgcggccca gtgcctctcc cacccctggt tcctgaaatc     4020

catgcctgcg gaggaggccc acttcatcaa caccaagcag ctcaagttcc tcctggcccg     4080

aagtcgctgg cagcgttccc tgatgagcta caagtccatc ctggtgatgc gctccatccc     4140

tgagctgctg cggggcccac ccgacagccc ctccctcggc gtagcccggc acctctgcag     4200

ggacactggt ggctcctcca gttcctcctc ctcctctgac aacgagctcg ccccatttgc     4260

ccgggctaag tcactgccac cctccccggt gacacactca ccactgctgc acccccgggg     4320

cttcctgcgg ccctcggcca gcctgcctga ggaagccgag gccagtgagc gctccaccga     4380

ggccccagct ccgcctgcat ctcccgaggg tgccgggcca ccggccgccc agggctgcgt     4440

gccccggcac agcgtcatcc gcagcctgtt ctaccaccag gcgggtgaga gccctgagca     4500

cggggccctg gccccgggga gcaggcggca cccggcccgg cggcggcacc tgctgaaggg     4560

cgggtacatt gcgggggcgc tgccaggcct gcgcgagcca ctgatggagc accgcgtgct     4620

ggaggaggag gccgccaggg aggagcaggc caccctcctg gccaaagccc cctcattcga     4680

gactgccctc cggctgcctg cctctggcac ccacttggcc cctggccaca gccactccct     4740

ggaacatgac tctccgagca ccccccgccc ctcctcggag gcctgcggtg aggcacagcg     4800

actgccttca gccccctccg ggggggcccc tatcagggac atggggcacc ctcagggctc     4860

caagcagctt ccatccactg gtggccaccc aggcactgct cagccagaga ggccatcccc     4920

ggacagccct tgggggcagc cagccccttt ctgccacccc aagcagggtt ctgcccccca     4980

ggagggctgc agcccccacc cagcagttgc cccatgccct cctggctcct tccctccagg     5040

atcttgcaaa gaggccccct tagtaccctc aagccccttc ttgggacagc cccaggcacc     5100

ccctgcccct gccaaagcaa gccccccatt ggactctaag atggggcctg gagacatctc     5160

tcttcctggg aggccaaaac ccggcccctg cagttcccca gggtcagcct cccaggcgag     5220

ctcttcccaa gtgagctccc tcagggtggg ctcctcccag gtgggcacag agcctggccc     5280

ctccctggat gcggagggct ggacccagga ggctgaggat ctgtccgact ccacacccac     5340

cttgcagcgg cctcaggaac aggcgaccat gcgcaagttc tccctgggtg gtcgcggggg     5400

ctacgcaggc gtggctggct atggcacctt tgcctttggt ggagatgcag ggggcatgct     5460

ggggcagggg cccatgtggg ccaggatagc ctgggctgtg tcccagtcag aggaggagga     5520

gcaggaggag gccagggctg agtcccagtc ggaggagcag caggaggcca gggctgagag     5580

cccactgccc caggtcagtg caaggcctgt gcctgaggtc ggcagggctc ccaccaggag     5640

ctctccagag cccaccccat gggaggacat cgggcaggtc tccctggtgc agatccggga     5700

cctgtcaggt gatgcggagg cggccgacac aatatccctg gacatttccg aggtggaccc     5760

cgcctacctc aacctctcag acctgtacga tatcaagtac ctcccattcg agtttatgat     5820

cttcaggaaa gtccccaagt ccgctcagcc agagccgccc tcccccatgg ctgaggagga     5880

gctggccgag ttcccggagc ccacgtggcc ctggccaggt gaactgggcc cccacgcagg     5940

cctggagatc acagaggagt cagaggatgt ggacgcgctg ctggcagagg ctgccgtggg     6000

caggaagcgc aagtggtcct cgccgtcacg cagcctcttc cacttccctg ggaggcacct     6060

gccgctggat gagcctgcag agctggggct gcgtgagaga gtgaaggcct ccgtggagca     6120

catctcccgg atcctgaagg gcaggccgga aggtctggag aaggaggggc cccccaggaa     6180

gaagccaggc cttgcttcct tccggctctc aggtctgaag agctgggacc gagcgccgac     6240

attcctaagg gagctctcag atgagactgt ggtcctgggc cagtcagtga cactggcctg     6300

ccaggtgtca gcccagccag ctgcccaggc cacctggagc aaagacggag cccccctgga     6360

gagcagcagc cgtgtcctca tctctgccac cctcaagaac ttccagcttc tgaccatcct     6420

ggtggtggtg gctgaggacc tgggtgtgta cacctgcagc gtgagcaatg cgctggggac     6480

agtgaccacc acgggcgtcc tccggaaggc agagcgcccc tcatcttcgc catgcccgga     6540

tatcggggag gtgtacgcgg atggggtgct gctggtctgg aagcccgtgg aatcctacgg     6600

ccctgtgacc tacattgtgc agtgcagcct agaaggcggc agctggacca cactggcctc     6660

cgacatcttt gactgctgct acctgaccag caagctctcc cggggtggca cctacacctt     6720

ccgcacggca tgtgtcagca aggcaggaat gggtccctac agcagcccct cggagcaagt     6780

cctcctggga gggcccagcc acctggcctc tgaggaggag agccaggggc ggtcagccca     6840

acccctgccc agcacaaaga ccttcgcatt ccagacacag atccagaggg gccgcttcag     6900

cgtggtgcgg caatgctggg agaaggccag cgggcgggcg ctggccgcca agatcatccc     6960

ctaccacccc aaggacaaga cagcagtgct gcgcgaatac gaggccctca agggcctgcg     7020

ccacccgcac ctggcccagc tgcacgcagc ctacctcagc ccccggcacc tggtgctcat     7080

cttggagctg tgctctgggc ccgagctgct cccctgcctg gccgagaggg cctcctactc     7140

agaatccgag gtgaaggact acctgtggca gatgttgagt gccacccagt acctgcacaa     7200

ccagcacatc ctgcacctgg acctgaggtc cgagaacatg atcatcaccg aatacaacct     7260

gctcaaggtc gtggacctgg gcaatgcaca gagcctcagc caggagaagg tgctgccctc     7320

agacaagttc aaggactacc tagagaccat ggagctcctg gagggccagg gggctgttcc     7380

acagacagac atctgggcca tcggtgtgac agccttcatc atgctgagcg ccgagtaccc     7440

ggtgagcagc gagggtgcac gcgacctgca gagaggactg cgcaaggggc tggtccggct     7500

gagccgctgc tacgcggggc tgtccggggg cgccgtggcc ttcctgcgca gcactctgtg     7560

cgcccagccc tggggccggc cctgcgcgtc cagctgcctg cagtgcccgt ggctaacaga     7620

ggagggcccg gcctgttcgc ggcccgcgcc cgtgaccttc cctaccgcgc ggctgcgcgt     7680

cttcgtgcgc aatcgcgaga agagacgcgc gctgctgtac aagaggcaca acctggccca     7740

ggtgcgctga gggtcgcccc ggccacaccc ttggtctccc cgctgggggt cgctgcagac     7800

gcgccaataa aaacgcacag ccgggcgag                                       7829


<210> 3316
<211> 2421
<212> DNA
<213> Homo sapiens

<400> 3316
actagccggt tactagctgc gcttttgttc cacttgagcg ggcactcttc tgcggcaagc       60

aggtctagga attcgcctgg ttcccacctc gcgtcccttg ccttccttcc tagtctaccc      120

actgtagtgc cccctgcgtc ccgctccctc ctagccgact cagagcacaa gaaggattgc      180

cacggtttcc attgcagcag ccgtggcgcc tctgaccctt tttttatatc gcggcgacgg      240

cgggctgtcg tcacgacgac gtgcggacgc agcggcgggg gcctttcagc ttatgtggag      300

aagtcgctgt gaagccacct ataaatccat ttactgaatt tatggagaag gctgtaaatg      360

atggaagtca ttcagaagaa ctcttttgcc atcttaaaac tatatcagag aaagaagatt      420

taccacggtg taccagtgaa agtcatctca gctgcctgaa gcaggacatt ctaaatgaaa      480

agactgaatt ggaagcaaca cttaaggaag cggagttggt aactcattct gtagaattgc      540

ttttgccact atttaaggac accattgaaa agattaattt tgaaaatgcg aatctttctg      600

cattgaattt gaagatttct gaacagaagg aaatattaat aaaagaatta gacaccttca      660

aaagtgtaaa actagcttta gaacatcttc ttagaaagag agactacaaa caaacaggag      720

acaatttatc cagcatgttg ctagaaaatc taactgataa tgaaagtgaa aatactaatc      780

ttaagaagaa ggtatttgaa aaggaggccc atatccaaga actttcttgt ttgtttcaga      840

gtgaaaaggc aaatactttg aaagcaaacc gtttttccca atcagtaaaa gtagtacatg      900

aacgactaca gatccaaatt cataaaaggg aagccgagaa cgataagttg aaagaatatg      960

taaagagctt agaaaccaag atagccaagt ggaacctgca atcaagaatg aataagaatg     1020

aggctatagt gatgaaagaa gcaagtaggc aaaaaactgt agctttaaaa aaggcatcta     1080

aagtttacaa acaaaggctt gaccatttta caggagctat tgaaaagctt acttcccaaa     1140

ttagagatca ggaagccaag ttgtctgaaa caatttcagc ttccaatgcc tggaaaagtc     1200

attatgagaa aattgtgata gaaaaaaccg aattggaagt acagattgaa acaatgaaaa     1260

agcaaatcat taatcttttg gaagatctga agaaaatgga agaccatgga aaaaattcat     1320

gtgaagaaat tcttagaaaa gttcactcaa ttgaatatga aaatgaaact ctgaatcttg     1380

agaatacaaa attaaagact acacttgctg ctttgaagga tgaagttgta tctgttgaaa     1440

atgaactctc agaattgcaa gaagtagaaa aaaaacagaa aacccttatt gaaatgtata     1500

aaactcaggt acaaaagttg caagaagcag ctgaaatagt aaaaagcaga tgtgaaaatt     1560

tgctacataa aaataaccaa ataacaaaaa ccaaaaataa aaatgtagag aagatgagag     1620

gccagatgga gtctcatctg aaggagttag agcgtgtctg cgattccttg acggcggcgg     1680

aacggaggct tcacgagtgt caggttgatg gaaatcacaa tcttctgaca aagctttctc     1740

tggaagagga aaactgtctt attcagctga agtgtgaaaa ccttcaacaa aaattagaac     1800

agatggacgc agaaaataaa gagcttgaga agaagctggc aaaccaagaa gaatgtctta     1860

agcacagcaa tcttaagttt aaagagaaat ctgcagagta tacagcattg gccagacaac     1920

tggaagctgc tttagaagaa ggaagacaaa aggttgctga agaaatagag aaaatgtcat     1980

ctagagagag tgctttacaa attaaaatat tagatctgga aactgagctt agaaagaaaa     2040

atgaagaaca aaatcaactt gtttgcaaaa tgaacagtac aaatggctaa ctacaataac     2100

cagtgtagag aagtccttaa atgacctgac ggagctgaaa accatggtat gagaactaca     2160

tgacaaatgc acaagcttca gtagccgatt cattcaactg gaagaaagga tatcagtgac     2220

tgaagatcaa atgaatgaaa tgaacaatcc tcccctcatc catggtttca ttttctatgg     2280

ttccagttac tcatggtcaa ccatggtcag aaaacaggac aaactgagag taaaagatgc     2340

aggaataaaa cacagaaatc aaaataaagg gtttactgct gaaaaatccg cttgaacaag     2400

cctgttaatg tgatcttcct g                                               2421


<210> 3317
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 3317
gggagaggcg ggctcgggcc cagcgccgcc cgcgcgaagc tccctggtgt tgtgcgccct       60

tccccgcgcg cggcccctcc tgctgggctg gggtctgtgg ctgacgtccg cttttcccgg      120

aacggcaaag agaagtcatt cagaattcaa aagaagttct aagtttattg caagaaaaaa      180

accctgcctt caagccggtt cttgcaatta tccaggcagg tgacgacaac ttgatgcagg      240

aaatcaacca gaatttggct gaggaggctg gtctgaacat cactcacatt tgcctccctc      300

cagatagcag tgaagccgag attatagatg aaatcttaaa gatcaatgaa gataccagag      360

tacatggcct tgcccttcag atctctgaga acttgtttag caacaaagtc ctcaatgcct      420

tgaaaccaga aaaagatgtg gatggagtaa cagacataaa cctggggaag ctggtgcgag      480

gggatgccca tgaatgtttt gtttcacctg ttgccaaagc tgtaattgaa cttcttgaaa      540

aatcagcttc acgaggctga cattgtggtc ctaggctcac ctaagccaga agagattccc      600

cttacttgga tacaaccagg aactactgtt ctcaactgct cccatgactt cctgtcaggg      660

aaggttgggt gtggctctcc aagaatacat tttggtggac tcattgagga agatgatgtg      720

attctccttg ctgcagctct gcgaattcag aacatggtca gtagtggaag gagatggctt      780

cgtgaacagc agcacaggcg gtggagactt cactgcttga aacttcagcc tctctcccct      840

gtgccaagtg acattgagat ttcaagagga caaactccaa aagctgtgga tgtccttgcc      900

aaggagattg gattgcttgc agatgaaatt gaaatctatg gcaaaagcaa agccaaagta      960

cgtttgtccg tgctagaaag gttaaaggat caagcagatg gaaaatacgt cttagttgct     1020

gggatcacac ccacccctct tggagaaggg aagagcacag tcaccatcgg gcttgtgcag     1080

gctctgaccg cacacctgaa tgtcaactcc tttgcctgct tgaggcagcc ttcc           1134


<210> 3318
<211> 2796
<212> DNA
<213> Homo sapiens

<400> 3318
cgctttgggg ttctgtgtgc agcgagcatg gtgtccttgg caccagggtt tcggcagagg       60

agcctagcgt gggcctactt ggactcctcc gcgtggggca gctcgggaca cccgggcctg      120

caggagagcg gggttctagg ctggccccgg ctctgcagtg cagccgggtg cctgccactc      180

gcggggctct gtcgcagtac tcgtgcctgg cgcctcccct cagccacaga gaccgcagta      240

gctccaacca tcgcacccct aactgggcca cgagttctct gattgccaga cctgttgtct      300

ttgccactca ctgttctgag taattggaga gtcgtgtatt cactacacgc caaccagagt      360

ggtcctgtaa aagcgtaagc ctagtgtaga tacgcttctg cttaaaactc ttgagtggct      420

cccagtgctt ttagaacaaa atccaaacgc ctttccgaag tcgacaaggc ccagcttgat      480

tgagcagaag atgtgatagg agatgaggag cggggggctt ctgcaaaagt gcttcggtcg      540

ctcaggcttt tggcacattt tgcttatgca acctagttct ttctacctta gggccttttc      600

ttgggaaagt tgggagtctc actctgctgc ctaggctgag tgcagtggtg tgatcgaggc      660

gcactgcagc cttgacctcc tgggctcaag cgatcctcac ctcggcctac cgagtagctg      720

ggactacagg cacgcgccac tacactcgga tttctgacag tcagacttgt ccacaagaac      780

tcaactggca aggctgcttt tctgtgctaa aactggggag ctagtgggca ccatgaagat      840

cttctgcagt cgggccaatc cgaccacggg gtctgtggag tggctggagg aggatgaaca      900

ctatgattac caccaggaga ttgcaaggtc atcttatgca gatatgctac atgacaaaga      960

cagagttttc aagcctatgg ctgatgctgc tgtgaagatt gtggagaaaa atggctttag     1020

tgataagatt aaggttatca acaagcattc caccgaggtg actgtaggtc cagagggtga     1080

catgccatgc cgtgccaaca tcctggtcac agagttgttt gacacagagc tgatcgggga     1140

gggggcgctg ccctcctatg agcacgcaca caggcatctc gtggaggaaa attgtgaggc     1200

cgtgccccac agagccaccg tctatgcaca gctggtggag tccgggagga tgtggtcgtg     1260

gaacaagcta tttcccatcc acgtgcagac cagcctcgga gagcaggtca tcgtccctcc     1320

cgttgacgtg gagagctgcc ctggcgcacc ctctgtctgt gacattcagc tgaaccaggt     1380

gtcaccagcc gactttacag tcctcagcga tgtgctgccc atgttcagca tagacttcag     1440

caagcaagtc agtagctcag cagcctgcca tagcaggcgg tttgaacctc tgacatctgg     1500

ccgagctcag gtggttctct cgtggtggga cattgaaatg gaccctgagg ggaagatcaa     1560

gtgcaccatg gcccccttct gggcacactc agacccagag gagatgcagt ggcgggacca     1620

ctggatgcag tgtgtgtact tcctgccaca agaggagcct gtggtgcagg gctcagcgct     1680

ctatctggta gcccaccacg atgactactg cgtatggtac agcctgcaga ggaccagccc     1740

tgaaaagaat gagagagtcc gccagatgcg ccccgtgtgt gactgccagg ctcacctgct     1800

ctggaaccgg cctcggtttg gagagatcaa tgaccaggac agaactgatc gatacgtcca     1860

ggctctgagg accgtgctga agccagacag cgtgtgcctg tgtgtcagcg atggcagcct     1920

gctctccgtg ctggcccatc acctgggggt ggagcaggtg tttacagtcg agagttcagc     1980

agcttctcac aaactgttga gaaaaatctt caaggctaac cacttggaag ataaaattaa     2040

catcatagag aaacggccgg aattattaac aaatgaggac ctacagggca gaaaggtctc     2100

tctcctcctg ggcgagccgt tcttcactac cagcctgctg ccgtggcaca acctctactt     2160

ctggtacgtg cggaccgctg tggaccagca cctggggcca ggtgccatgg tgatgcccca     2220

ggcagcctcg ctgcacgctg tggttgtgga gttcagggac ctgtggcgga tccggagccc     2280

ctgtggtgac tgcgaaggct tcgacgtgca catcatggac gacatgatta agcgtgccct     2340

ggacttcagg gagagcaggg aagctgagcc ccacccgctg tgggagtacc catgccgcag     2400

cctctccgag ccctggcaga tcctgacctt tgacttccag cagccggtgc ccctgcagcc     2460

cctgtgtgcc gagggcaccg tggagctcag aaggcccggg cagagccacg cagcggtgct     2520

atggatggag taccacctga ccccggagtg cacgctcagc actggcctcc tggagcctgc     2580

agaccccgag gggggctgct gctggaaccc ccactgcaag caggccgtct acttcttcag     2640

ccctgcccca gatcccagag cactgctggg tggcccacgg actgtcagct atgcagtgga     2700

gtttcacccc gacacaggcg acatcatcat ggagttcagg catgcagata ccccagactg     2760

accactcttg agcaataaag tggcctgagg gctggg                               2796


<210> 3319
<211> 602
<212> DNA
<213> Homo sapiens

<400> 3319
gttaaaaggg gactgacagg atgaaggcag tacagaatgc tgggctgaga gcaggactga       60

gatcctagag gcagaatccc agtctacccg tactctctgg gaggaagtga tgagaacttg      120

cagcagggtg gtggtagtga aagagaagaa tgaaagacaa ggaagcatca gtggaacttg      180

atgtgtggct ggataccaga aatgcagagg aagttagtca aaggttcccg tcctgatgac      240

tggagatcat ggtatcactg actgagctct aggggttgtg aaatagagct cattaggcag      300

aggatggttg tcaagttatt aagcaacaaa agatcacaag cagttggaat actaatgtct      360

agccttcatt tagatatgaa agacatacaa catgctgttg tgaacttgga taattctgtg      420

gttgacctgg agacccttca agctctctat gagaatagag cacagtcaga cgaactcgaa      480

aaaatagaaa agcatggccg atcttccaaa gacaaggaaa atgccaagtc tctggacaaa      540

cctgaacagt tcctttatga actgtcacta atccccaact tttcagagcg agtcttttgc      600

at                                                                     602


<210> 3320
<211> 609
<212> DNA
<213> Homo sapiens

<400> 3320
aagcggttcc cgagcccagg cccgcgccga gcccagcagg cacccaccca cggcccttcc       60

tggtatctgg accagaccag gtcctagagc agctccagca ggatggcggc tccagcgtct      120

ctaaggcctg cagggggtcc agccccatgg ggggcgccct aggcctccga cagctcccca      180

tctgtgctcc tgcctgccgg ccatcctcag gccactcgcc atgggcggct gcttctccaa      240

acccaaacca gtggagctca agatcgaggt ggtgctgcct gagaaggagc gaggcaagga      300

ggagctgtcg gccagtggga agggcagccc ccgggcctac cagggcaatg gcacggcccg      360

ccacttccac acggaggagc gcctgtccac ccctcacccc taccccagcc ctcaggattg      420

cgtggaggct gctgtctgcc acgtcaagga cctcgagaat ggccagatgc gggaagtgga      480

gctgggctgg gggaaggtgt tgctggtgaa ggacaatggg gagttccacg ccctgggcca      540

taagtgtccg cactacggcg cacccctggt gaaaggcgtt ctgtcccgtg gtcgggtgcg      600

ctgcccctg                                                              609


<210> 3321
<211> 797
<212> DNA
<213> Homo sapiens

<400> 3321
aaactttgag cggaccggga cagaaaaaaa aatctctctt tgtcttgagg gggctgttga       60

gtggtcgcgg acctgggctc tgtgcgttgg gaaagggaag tggaggtgag cctcgggctt      120

cccgccctgt agctgggccc gccccagttg cagcgctcag ccccaccccg gctgggccac      180

cgccctgcac agtctcaggg atgagcagcc gcccaagctg cagggcctcg ggtcttcggc      240

gcctctgacc ctcgcaggtt gctgcctttc ggtgcagaac cgtatgtatg tcacacattg      300

gatgtgagac ctgagaaacc gtgttttaac aggtctctga aagaagatga atttggctga      360

gatttgtgat aatgcaaaga aaggaagaga atatgccctt cttggaaatt acgactcatc      420

aatggtatat taccaggggg tgatgcagca gattcagaga cattgccagt cagtcagaga      480

tccagctatc aaaggcaaat ggcaacaggt tcggcaggaa ttattggagg aatatgaaca      540

agttaaaagt attgtcagca ctttagaaag ttttaaaatt gacaagcctc cagatttccc      600

tgtgtcctgt caagatgaac catttagaga tcctgctgtt tggccacccc ctgttcctgc      660

agaacacaga gctccacctc agatcaggcg tcccaatcga gaagtaagac ctctgaggaa      720

agaaatggca ggagtaggag cccggggacc tgtaggccga gcacatccta tatcaaagag      780

tgaaaagcct tctacaa                                                     797


<210> 3322
<211> 748
<212> DNA
<213> Homo sapiens

<400> 3322
ggggctgctt ctgaggaatc agcttgactg gaagggtccc cattccttct ttccgatccg       60

cgattaccct ggactcgaag tcagcagacc cggttctagg ccagctctgc ctctcaccct      120

ctgtgacctt gggcaaatca tacaactctg ggactcagtt tcttcctctc taaaacggag      180

atgactgttg ctccatcagt ctcagccagc aagttcagct ccggcaagtc atttgattca      240

cccggtgatg aaatgggggt caaccagtct gtgggctttc cacctgtcac aggaccccac      300

ctcgtaggct gtggggatgt gatggagggt cagaatctcc aggggagctt ctttcgactc      360

ttctacccct gccaaaaggc agaggagacc atggagcagc ccctgtggat tccccgctat      420

gagtactgca ctggcctggc cgagtacctg cagtttaata agcgctgcgg gggcttgctg      480

ttcaacctgg cggtgggatc ttgtcgcctg cctgttagct ggaatggccc ctttaagaca      540

aaggactctg gatacccctt gatcatcttc tcccatggcc taggagcctt caggactttg      600

tattcagcct tctgcatgga gctggcctca cgtggctttg tggttgctgt gccagagcac      660

agggaccggt cagcggcaac cacctatttc tgcaagcagg ccccagaaga gaaccagccc      720

accaatgaat cgctgcagga ggaatgga                                         748


<210> 3323
<211> 2880
<212> DNA
<213> Homo sapiens

<400> 3323
agcatttagt tgggatagct tcactagagc tgcctgccaa agacttcctt ccacaggatc       60

ttgtcgcacc agcaactgac aggagcttgg gagctcggga gcttgggaga gggcttatgt      120

ttttaataat gtagctgtca gttcgaagcc tggaaatgtt gaccctcaaa ggtttattgc      180

caaaattaga taccatattt atgctgaatt attacctttt caatagtttt ttttgacctt      240

gcagactact gtattcttta tacctaggga agcatgtcta tgtttggaac ctgcaaataa      300

tttttcagtc atcttagaga tgctgcagaa catcaatgcc acatcttgag tcagaagtcg      360

agggtcattt gttcaaaagt tggagaaata tcctcttttg ttgcttcttc tactctgtag      420

tggagaatgg ggaactggta gttgtgtggg agttatgtgt ctctaagatt tgtcgaccca      480

ttttgatggc aaggtgtatt cacaagtgtg tgtaaagggg gtgtggatgg gacaactgca      540

tctgcctctt gtgcatgcct tgggtacttg atttcatctt gttttttccc ccttttgtat      600

aaaattctca aaattgctca tttggatttg aatatgaaag gagaaatgaa atctctaaag      660

aatgatagta aataccttgc actgacttta ttttctgata tcttaacctt ctagggcata      720

aaatcttgtt attttaattt gcatctggga gaatgtctga gcaaggagac ctgaatcagg      780

caatagcaga ggaaggaggg actgagcagg agacggccac tccagagaac ggcattgtta      840

aatcagaaag tctggatgaa gaggagaaac tggaactgca gaggcggctg gaggctcaga      900

atcaagaaag aagaaaatcc aagtcaggag caggaaaagg taaactgact cgcagccttg      960

ctgtctgtga ggaatcttct gccagaccag gaggtgaaag tcttcaggat cagactctct     1020

gaaaactgca aatggaaagg aattcaaaag aatttagatt aaaagttaaa taaaaagtag     1080

gcacagtagt gctgaatttt cctcaaaggc tctcttttga taaggctgaa ccaaatataa     1140

tcccaagtat cctctctcct tccttgttgg agatgtctta cctctcagct ccccaaaatg     1200

cacttgccta taagaaacac aattgctggt tcatatgaaa cttaggaaat agtgaataag     1260

gtgcatttaa ctttggagaa atacttttat ggctttggtg gagatttctc aatactgcaa     1320

aagttgtcca gaaatgaatc tgagctgatg gtgactttaa gttaatatta ttaatatatc     1380

actgcatatt tttaccctta tttttgctcc ttacagcaag attagtaggt tataaaaatt     1440

taaatttaaa caaaattatt tcatgacaaa atgggaaact tcacatcata cttatttttg     1500

tttgcctttc aggcatcata ttagctttta taaaaaatgg tcttgctgct gaaattgtac     1560

ttattttatc agaggctggg tgcagtcaag acaaaagtaa aatggtttac ctgagcccag     1620

gggagggaaa attgattaag atatcattat ttttgtttgg tttggttttg cttttttcct     1680

cttactttaa ttgaaatact ctgaattccc ctcatggaaa cagagagcat tgagagcact     1740

ttctttaaaa ggaccaaaaa taaattccta atagattttg tcctaagaga gtgttttttt     1800

ttctagcatc attttcttta catgccactc atgtcataag gcatggacag gctatctttc     1860

agtggccatt actatgtttc gtacacatgc tttattttac ttgggctctg agaaatgtgt     1920

ggctttcctt cagcatttta tttgtgcttc tctttttaat ggagattgaa aagggagaat     1980

aatgtgaata tcacggctta tattattaaa tgttgattga tggcttgtaa tgtactgcac     2040

acaatatatg ttaactctgc agaatgacag accctgggag aagtaatgcc ccagttgtcc     2100

cccactccta atgccaggca gagaaggaca gcctttatag acttaatctg ctttttgtcc     2160

catttgacaa ggtaccagga ggaaattttt taagggatca actgtatcac agtgcccact     2220

ctggacctaa gtctagtgta tccatacaat tggtgcagag aaataaggtg taaatggtgc     2280

tttgttcctg ctggttccaa gctcagaaac caagactagc tttgtaggag agaatgagag     2340

cctgcaagcc tctctttgga ttggctgagg agtggtggga gcagggggtt gatagaaaac     2400

atccagacac acatataagc aagtggccgt gctacctttt tagagaataa agaaacagac     2460

ttttgagttt atatgcaatg ccttcattag gtaccaccgg cacttacaaa atgtgcggac     2520

tgaatcccag agaacactgg cagatgtata cagtatatgg attgtatcgc ttccccaatg     2580

tttgtaaatt cacagtattt ggaaaactgc cttcattttc cagtgtggga aaaactcttg     2640

ctacctgtat tacttgatct cagacccata cctgatggtt cagtctgtcc ttaagttaaa     2700

agaattttgc ttttctaatg ttatactatt tacctgtcag tgtattactg caacttgaat     2760

cactctttta ctgttgttgg atataaactt atcctgtacc aatgtattta ttaacacttg     2820

tattttatta ttgagcatat caataaaaat attaaaaaat aacagattgt tttttaccaa     2880


<210> 3324
<211> 9438
<212> DNA
<213> Homo sapiens

<400> 3324
cagcgcgcgc tcctgcagcc ccggcggagt cccggcgggg agcgcccgcg taggcaggca       60

cccggggcag ccctccgtcc tcgccgcgcg gcctgagaac ccctgggccc tgggcgaggg      120

ggctgggctg tgcagccccc gaggctaact gggcgggatc gcagctgcag gggttgtgcg      180

agcagccacg gcggcacctg tgccctgcgg gcacccaccc tgcccctgcc gaggcaggcg      240

cccaccgccg gcggtgatgc ggctgtgaag ccctagtcga ttaacgtgac agtgtcaggt      300

ggacccacag ccatcccacc tccccctctg gggagtgctg agagtgaggc agcatggagg      360

agaggaagca tgagaccatg aacccagctc atgtcctctt tgaccggttt gtccaggcca      420

ccacctgcaa gggaaccctc aaggctttcc aggagctctg tgaccacctg gaactaaagc      480

caaaggacta ccgctccttc tatcacaagc tcaagtccaa gcttaactac tggaaagcca      540

aagccctctg ggcaaaattg gacaaacggg gcagtcacaa agactacaaa aagggaaaag      600

cgtgcactaa caccaagtgt ctcatcattg gggctggccc ctgtggtctc cgtacagcca      660

tcgacttatc cttactgggg gccaaggtgg ttgttattga gaaacgagat gccttctccc      720

gcaacaacgt cttgcatctc tggccattca ccatacatga tctacgaggt ctgggtgcca      780

agaagttcta tggcaagttc tgtgctggag ccatcgacca tatcagtatc cgtcagctcc      840

aactaatact tttgaaagta gccttgatcc taggcattga aatccacgtc aatgtggaat      900

tccaaggact tatacagcct cctgaggacc aagagaatga acggataggc tggcgggcac      960

tggtgcaccc caagactcat cctgtgtcag agtatgaatt tgaagtgatc atcggtgggg     1020

atggtcggag gaacaccttg gaagggtttc gtcggaaaga attccgtggc aaactggcca     1080

tcgccatcac ggcaaatttt atcaaccgaa atacaacagc agaagctaaa gtggaagaga     1140

tcagtggtgt ggcttttata ttcaaccaaa aatttttcca ggaactgagg gaagccacag     1200

gtattgactt ggagaacatc gtttactaca aagatgacac acactatttc gttatgacag     1260

ccaaaaagca gagtttgctg gacaaaggag tgatactaca tgactacgcc gacacagagc     1320

tcctgctttc ccgagaaaac gtggaccagg aggctctgct cagctatgcc agggaggcgg     1380

cagacttctc tacccagcag cagctgccgt ctctggattt tgccatcaat cactatgggc     1440

agcccgatgt ggccatgttt gacttcactt gtatgtatgc ctccgagaac gccgccttgg     1500

tgcgggagca gaacggacac cagttactag tggctctggt cggggacagc ctcctagagc     1560

ctttctggcc aatgggaaca ggaatagccc ggggctttct agctgctatg gactctgcct     1620

ggatggtccg aagttggtct ctaggaacga gccctttgga agtgctggca gagagggaaa     1680

gtatttacag gttgctgcct cagaccaccc ctgagaatgt gagtaagaac ttcagccagt     1740

acagtatcga ccctgtcact cggtatccca atatcaacgt caacttcctc cggccaagcc     1800

aggtgcgcca tttatatgat actggcgaaa caaaagatat tcacctggaa atggagagcc     1860

tggtgaattc ccgaaccacc cccaaattga ctcgcaatga gtctgtagct cgttcaagca     1920

aactgctggg ttggtgccag aggcagacag atggctatgc aggggtaaac gtgacagatc     1980

tcaccatgtc ctggaaaagt ggcttggccc tttgtgcaat tatccataga taccgccctg     2040

acctgataga ttttgattct ttggatgagc aaaatgtgga gaagaataac caactggcct     2100

ttgacattgc tgagaaggaa ttgggcattt ctcccatcat gacaggcaaa gaaatggcct     2160

ccgtggggga gcctgataag ctgtccatgg tgatgtacct gactcagttc tacgagatgt     2220

ttaaggactc cctcccctct agcgacacct tggacctaaa tgccgaggag aaagcagtcc     2280

tgatagccag caccagatcc cctatctcct tcctaagcaa acttggccag accatctctc     2340

ggaagcgttc tcccaaggat aaaaaggaaa aggacttgga tggtgctggg aagaggagaa     2400

agaccagtca atcagaggag gaggaagctc ctcggggcca cagaggagaa agaccgaccc     2460

tggtgagcac tctgacagac aggaggatgg acgttgccgt tgggaaccag aacaaagtga     2520

agtacatggc gacccagctg ctggccaaat ttgaagagaa tgcgcccgca cagtccatcg     2580

gcatacggag acagggctcc atgaagaagg agttcccgca gaacctggga ggcagcgaca     2640

catgctactt ctgccagaag cgggtctacg tgatggagag gctgagtgcc gagggcaagt     2700

tcttccaccg gagctgcttc aagtgcgagt actgcgccac caccctgcgc ctctcggcct     2760

acgcctacga catcgaggat ggtaaattct actgtaagcc acactactgc tatcgactct     2820

ctggctacgc acaaaggaag agaccggcag tggctcccct gtctggaaag gaggccaaag     2880

gacccctgca ggatggcgcc accacagatg caaacggacg ggccaacgcc gtggccagct     2940

ccactgagag aaccccaggt tcaggcgtga acggcctgga ggagcccagc atcgccaagc     3000

gactgagggg caccccagag cggatcgagc tggagaacta ccgcctgtcc ctgaggcagg     3060

ctgaggcact gcaggaggta ccggaggaga ctcaggccga gcacaacctg agcagcgtgc     3120

tggacacggg cgccgaggag gacgtcgcca gcagtagttc cgagtctgag atggaggagg     3180

agggagagga ggaggaggag gagcctcgcc tgcccccatc tgacctgggt ggtgttccgt     3240

ggaaggaggc cgtgcggatc catgcccttc tgaaagggaa aagtgaagag gagctagagg     3300

cctcaaagag ctttgggcct gggaatgaag aggaggagga ggaggaggaa gaatatgaag     3360

aggaggagga ggaggactat gacgaggagg aggaagagtc cagtgaagcc gggaaccaga     3420

ggctccagca ggtcatgcac gcggcggatc ctctggagat ccaggctgac gtgcactgga     3480

ctcatatccg tgagagagag gaggaagaga ggatggcgcc ggcctctgag tcctctgctt     3540

ccggagcccc attggatgag aatgacctag aggaagatgt ggactcagaa ccagccgaga     3600

tagaagggga ggcagcagag gatggggacc caggggacac tggtgctgag ctggatgatg     3660

atcagcactg gtctgacagc ccgtcggatg ctgacagaga gctgcgtttg ccgtgcccag     3720

ctgaggggga agcagagctg gagctgaggg tgtcggaaga tgaggagaag ctgcccgcct     3780

caccgaagca ccaagagaga ggtccctccc aagccaccag ccccatccgg tctccccagg     3840

aatcagctct tctgttcatt ccagtccaca gcccctcaac agaggggccc caactcccac     3900

ctgtccctgc cgccacccag gagaaatcac ctgaggagcg ccttttccct gagcctttgc     3960

tccccaaaga gaagcccaaa gctgatgccc cctcggatct gaaagctgtg cactctccca     4020

tccgatcaca gccagtgacc ctgccagaag ctaggactcc tgtctcacca gggagcccgc     4080

agccccagcc acccgtggcg gcctccacgc ccccacccag cccactcccc atctgctccc     4140

agccccagcc ttccaccgag gccactgtcc catcccctac ccagtccccc atacgcttcc     4200

agcctgcccc ggccaaaaca tccaccccac tggcccctct ccctgtccaa agccaaagtg     4260

acaccaagga cagactgggc agcccccttg ctgtggatga ggccctcaga cggagcgacc     4320

tggtggagga gttctggatg aagagtgcgg agatccgccg cagcctcggg ctcacacctg     4380

tggaccgcag caaggggccc gagcccagct tccccacgcc tgccttcagg ccagtgtccc     4440

tcaaatccta ttccgttgaa aagtcccccc aggatgaggg actccacctt ctcaagcctc     4500

tgtccatccc caaaaggctg ggcctgccaa agccggaagg cgagccgttg tccctgccaa     4560

ccccccggtc cccgtccgac agagagctac gcagcgccca ggaggagcgc agggagctgt     4620

ccagcagctc tggcctgggc ctgcacggga gctcctccaa catgaagaca ctgggcagcc     4680

agagcttcaa cacctcggac tccgccatgc tcacgccccc ctccagcccg cccccaccgc     4740

cacccccggg cgaggagccc gccaccttgc ggaggaagct cagggaggcc gagcccaatg     4800

cctcggtggt cccgccgccc ttgcccgcca cctggatgcg gcccccccgg gagcctgctc     4860

agccccccag agaggaggtg cggaagtcgt ttgtggagag cgtggaggag attccctttg     4920

ctgatgatgt ggaggacacc tatgacgaca agactgagga ctcaagcctg caggagaaat     4980

tcttcacgcc cccgtcctgc tggccgcgcc ccgagaagcc tcgccacccg cccctggcca     5040

aggagaacgg gaggctgcct gctctggagg ggacgctgca gccacagaag agggggctgc     5100

ccttggtgtc cgcggaagcc aaggagttgg ccgaggagcg catgcgagcc agggagaagt     5160

ccgtgaagag ccaggcgctg cgggacgcca tggccaggca gctgagcagg atgcagcaga     5220

tggagctggc ctcaggcgcc cccaggcccc gcaaggcgtc ctcagcaccc tcccagggca     5280

aggagcgccg gcctgactcc cccacacgcc ccactctcag gggctccgag gagcccaccc     5340

tgaagcatga agccaccagc gaggaggtcc tctccccgcc gtcggactca gggggcccag     5400

atggctcttt cacttcatcc gagggctcca gtgggaagag caagaagagg tcgtcactct     5460

tctccccccg cagaaacaag aaggagaaga agtccaaagg cgagggccgg cccccggaga     5520

agcccagctc caacctccta gaagaagccg ccgccaaacc caagtccctg tggaagtccg     5580

tcttctccgg gtacaagaag gacaagaaga agaaggccga cgacaagtcc tgccccagca     5640

ccccctccag cggggccacg gtggactctg gaaagcacag ggtgcttccc gtcgtaaggg     5700

cagagctgca gctccggcgc cagctgagct tctccgagga ctcagacctc tccagcgacg     5760

atgtccttga gaagtcctca cagaagtccc ggcgagagcc aagaacctac acggaggagg     5820

aactgaatgc caagctgacc cggcgtgtgc aaaaggcagc tcggagacag gccaagcagg     5880

aggagcttaa gcggctgcat cgagcccaga tcatccagcg gcagctgcag caggtggagg     5940

agaggcagcg gcggctggag gaaaggggcg tggctgtgga gaaggcgctc cggggcgaag     6000

caggcatggg caagaaggac gaccccaagc tgatgcagga gtggttcaag ctagtgcagg     6060

agaagaacgc catggtgcgc tacgagtcgg agctgatgat ctttgcccgg gagctggagc     6120

tggaagaccg gcagagtcga ctgcagcagg agctccggga acgcatggca gtggaagatc     6180

accttaagac tgaggaggag ctgtcagaag agaagcagat tctcaatgag atgctggagg     6240

tggtggagca gagagactca ctggtggcgc tgctggagga gcagcggctc cgggagagag     6300

aggaggacaa ggacctggag gctgccatgc tgtccaaggg cttcagcctt aactggtcct     6360

gagctcccac ccaacgctcc attttctgtt ggcatccgcc tggccaggca gtggcatcca     6420

aaccacccgg agccgcgatc tgaggaggcc tggcacctcc ttggagttta cgctcagatg     6480

cccgtgtgct gcttggaaag tggtcgagtc ccgcgtgcag tggggagccc caggtgacag     6540

tggttatctg agacggctcc acctcctggg aggaggccca cctggacctc ccactcagag     6600

gagcagcacg gcgtgtatgg catgacgcag gggaccaccc cgcgcgctcc ctgaggatgt     6660

gctggctgtg cccctttttt ccactggcac atttggtaag agagggaagc tgctccccgt     6720

cagaaccaca gtgcgccgtg cgaggggcac tgtcttcttc atgctccctg gagcaccacc     6780

aaagaaacgt aaacaatacc ccacgaaagc agggtcaggg gtcagggtgc gatcgagacc     6840

caggatgggg gcgtccagtc atgcccaccc cagcatcaca ggagacatgg aggtgcgggc     6900

aggctcctga attattatgc aaattaggag gacgcaggag gggtctgccc tccagccgaa     6960

caccacacac tggaccctaa gtggccaaat gcctgggccg cttgctggct gtggcctgag     7020

gcttgtgggt tgctgcattt tgcttgtagt tcacaaccat tttgacactg gaaaatgctg     7080

actttggggg acaggatgag gccctacatt ctaagccccc agttggcaga caggcattgt     7140

ccctgttcca catttatgtc gggacaggag atgacctttt cctccgtgtt tttcctgtgt     7200

ttgcacgttg aaatgaagct gacaacctgg caagacgctc agccgcttca aacccttttt     7260

gtcaattaac ttatttttta atacttgaaa agaagtaact tcgtttgtgt atctttacta     7320

gaggaactga tcacctgcgc ccgggtgcgg gagccacagc ggcatctggt gcgtcctacg     7380

cgacctggtc cggggctgcc cggtgctcct cacgtgcatc tatttattag cctttctctt     7440

cgtatcactg gcctggctgg catcagggag ctgcccagaa cccctgtgtg ggtcctcctc     7500

acagctttct gtcccctcct ccacccggtg cctgcctcac cctggcgcta gaccatctgg     7560

accactcatg tgatgagggt gcatttccgt tctgttttgg gccaggccaa cagcagagct     7620

gccactctca ccctcccagt gagaattccg gctctgcaga actcgccctt gtctcagttt     7680

gggggccagg gcatcacctt cctccgcaca tatgttaaag aaggtttcag gatgggccct     7740

catccacaca ggccaagagg gtgcaaggtg ggaccctgga atcatgtggc tggtgagaat     7800

tccctcctcc cagcctaaga ttcacccaga cggaaacgcg agtgctgcag tggatgctgg     7860

gatgcaggct ggtgcctctc aagcagatca gcgactcccg cccttccttc cgaaggcgac     7920

gggcacctgc cttgtgccgg atcttcatgg ggacataaag ggcgagcccc gaatcactag     7980

ctcctatagc caaactgttc ctttctcacg gttccgcacc agcctggctg tgtacagctc     8040

atcaagccac tgagctaatc ggggtggggt gcttgtccat caaagcagtc agcacatagc     8100

ccagcgagga gccatccgga ccagacccgc ctgccagggg cgctccagcc gcctgccgcc     8160

tccgtgggct ggggccagct gggagcagag gcctggcccc tccaaggcgt cccgcagtgg     8220

agcaggctga gtggctgtgc tgaccttggg ctttccatgg gaaccacact gtgcttcaac     8280

ttgaacattc atcccagctg caaaggagca aagaacctgt gtcatccttg tctgtccaga     8340

agctgccatc tctctcccat gcacatccgg gagataacgc cgctagtggc cgccacagcg     8400

ctgattctcc acctgttctc acgtgaggca aaggtctcct tttcttttct ctttacttaa     8460

aaaaggggag aggagggttt ctagattcca tcttcaaacc ccagtcgtcc cataaaattg     8520

gacgtgggaa aagaccttca ctgcctgcgt ggcctttccc agacctctcc tcgaatgcca     8580

caaaaccggt ccagccccgg cagagccgcc ttcggccctt gtagctcctg ctggccccac     8640

aacagggaaa cagtttgcaa agtggcttgg aaggagtgtg gcctagggat ctgctgtaag     8700

tggccagacg tagcaggaga gcccagtgtc accttctggt cctggtcagc cttaacactg     8760

tggcatcctc cacagcacac acggcagcct gcagtctgga aggtggaccc gagcctttgc     8820

agagaggcgc cgcagagccg caggcctgcg ccccagcctt ctgctcccga ctgtgaggac     8880

acccagttct agtagagcac tttttttaaa gctcccattt tgtaaccact agtttgcggt     8940

tgacttgagt actctggtga cttcctgcgt caagcgttct caagctgtga gaatgtgcgc     9000

agctccaggc aggttttctc tcggagagtt aagtcttccc ttgaaggcag ggaagcagga     9060

tggatacaca tatatcacac gcataaaaca ccaggtgcgg gagcagccca gactcaaggc     9120

tgactaaact ggaggctgaa taccgtggag gtccacatgc agcttccctg gagggcaggc     9180

cggaggcgct cccgcccctg ggcttgagga tgctgcaccc cgtgggcttc caggcctgcc     9240

cagatgatgc cttcaggcct ctgtccctgg cggccatcct caggccgatt ttgaccagca     9300

atgatagact cttcttaacc ctttcaaaat aaatttttca gtgggacaga aaggagagtt     9360

aaaaaacatt tttttaaagg tggtaacatc tgacccacaa agggaatggg tctgttttat     9420

gcaaaataaa agtttttc                                                   9438


<210> 3325
<211> 1040
<212> DNA
<213> Homo sapiens

<400> 3325
gtatgtgggg ccgtgtgcag acccgcgtgt ggcgcaggca aggaccctca aaataaacag       60

cctctacctt gcgagccgtc ttccccaggc ctgcgtccga gtctccgccg ctgcgggccc      120

gctccgacgc ggaagatctg actgcagcca tgagcagcaa tgagtgcttc aagtgtggac      180

gatctggcca ctgggcccgg gaatgtccta ctggtggagg ccgtggtcgt ggaatgagaa      240

gccgtggcag aggtggtttt acctcggata gaggtttcca gtttgtttcc tcgtctcttc      300

cagacatttg ttatcgctgt ggtgagtctg gtcatcttgc caaggattgt gatcttcagg      360

aggatgttga agcctgctat aactgcggta gaggtggcca cattgccaag gactgcaagg      420

agcccaagag agagcgagag caatgctgct acaactgtgg caaaccaggc catctggctc      480

gtgactgcga ccatgcagat gagcagaaat gctattcttg tggagaattc ggacacattc      540

aaaaagactg caccaaagtg aagtgctata ggtgtggtga aactggtcat gtagccatca      600

actgcagcaa gacaagtgaa gtcaactgtt accgctgtgg cgagtcaggg caccttgcac      660

gggaatgcac aattgaggct acagcctaat tattttcctt tgtcgcccct cctttttctg      720

attgatggtt gtattatttt ctctgaatcc tcttcactgg ccaaaggttg gcagatagag      780

gcaactccca ggccagtgag ctttacttgc cgtgtaaaag gaggaaaggg gtggaaaaaa      840

accgactttc tgcatttaac tacaaaaaaa gtttatgttt agtttggtag aggtgttatg      900

tataatgctt tgttaaagaa ccccctttcc gtgccactgg tgaataggga ttgatgaatg      960

ggaagagttg agtcagacca gtaagcccgt cctgggttcc ttgaacatgt tcccatgtag     1020

gaggtaaaac caattctgga                                                 1040


<210> 3326
<211> 1833
<212> DNA
<213> Homo sapiens

<400> 3326
gcacgagcag ttcccgtggg cagtgggctc aggggcctgc aacggaccct acctcttgta       60

gtgattctcg gggccacggg caccggcaaa tccacgctgg cgttgcagct aggccagcgg      120

ctcggcggtg agatcgtcag cgctgactcc atgcagcccc aggagatggg cactgagaaa      180

gtgattgacc gaaaagtgga gcttgaaaag gaggatggtc ttgtacttca caaacgccta      240

agccaggtgg acccagaaat ggctgccaag ctgcatccac atgacaaacg caaagtggcc      300

aggagcttgc aagtttttga agaaacagga atctctcata gtgaatttct ccatcgtcaa      360

catacggaag aaggtggtgg tccccttgga ggtcctctga agttctctaa cccttgcatc      420

ctttggcttc atgctgacca ggcagatgag cgcttggata agagggtgga tgacatgctt      480

gctgctgggc tcttggagga actaagagat tttcacagac gctataatca gaagaatgtt      540

tcggaaaata gccaggacta tcaacatggt atcttccaat caattggctt caaggaattt      600

cacgagtacc tgatcactga gggaaaatgc acactggaga ctagtaacca gcttctaaag      660

aaaggtattg aggctctgaa acaagtaact aagagatatg cccggaaaca aaaccgatgg      720

gttaaaaacc gttttttgag cagacctggt cccattgtcc cccctgtcta tggcttagag      780

gtatctgatg tctcgaagtg ggaagagtct gttcttgaac ctgctcttga aatcgtgcaa      840

agtttcatcc agggccacaa gcctacagcc actccaataa agatgccata caatgaagct      900

gagaacaaga gaagttatca cctgtgtgac ctctgtgatc gaatcatcat tggggatcgc      960

gaatgggcag cgcacataaa atccaaatcc cacttgaacc aactgaagaa aagaagaaga     1020

ttggactcag atgctgtcaa caccatagaa agtcagagtg tttccccaga ccataacaaa     1080

gaacctaaag agaagggatc cccagggcag aatgatcaag agctgaaatg cagcgtttaa     1140

gagacatgtc cagtggcctt tggaaaggtg gtggggatcc agttcaggag ggaggggtat     1200

gtttgtctcc cagtctgggc aaaggagtgc tatgcggaat tctctgcata gcagaaaagc     1260

tcccaccatt ttcttttgat gtggttttaa agtctcacgt tctctataat agaaacagca     1320

ggtcttgtca gctccttgtg tggctgatgt gtctggaaat gatgtagttc aggaaagcat     1380

tttttttttc tttgaacctt aaaggttcta ttattaaaag cagcacagat tccacatttt     1440

tatacatgag gatcttcttt gtggtgaata ccaggattga ctgcatccct ttaaagaagt     1500

tttatgtccc tgactctggc taaaattatc taatttccag atgcttttgt agatgactga     1560

agtatttgtg agccacatat tgggagttct agatttgagt gaatggcagg aaagggccat     1620

ctccattgag atgattaagt gaaccaaact agttctcaga attctacaga gaaggaggga     1680

atcagactga ggaagctgtg acataggact tgaagaccaa agactttgaa atttgcgagc     1740

tgctcatgtg tgagttatta tcactgctgt ctttctattg agttacaaat ctatattttt     1800

attgaagttt aaataaagaa aaaatttaca aga                                  1833


<210> 3327
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 3327
ccggagcggg gatcacctca acttgactgt ggtcccccag ccctccaaga aatgcccata       60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa      120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt      180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt      240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca      300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc      360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc      420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc      480

tcctccatcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc      540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg      600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc      660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg      720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct      780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc      840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc      900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac      960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga     1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg     1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg     1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct     1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc     1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta     1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct     1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat     1440

ataattcccc tctgga                                                     1456


<210> 3328
<211> 1014
<212> DNA
<213> Homo sapiens

<400> 3328
ctctgacacc cctcattcaa aggcacctcc caccccgcac ctcagccttg gcggagagga       60

ctcacagcat tggacacatt tccaccatgc taatggcatt ttaaatatat ttggcaattt      120

tcccaatttt ttactgaaga aaactgtaag tttatacttg aggactgaag tgtgactctg      180

ccgattatca ggctttcaag atgaatctgg aaaaactcag caagcctgaa ctcctgacac      240

tatttagtat tcttgaagga gagcttgaag caagggacct tgttatagaa gccttaaagg      300

cccaacacag agatactttc attgaagaac gctatggaaa atataacatc agtgatcctt      360

taatggctct acagagagat tttgaaacac tgaaggagaa aaatgatggc gaaaagcagc      420

cagtctgcac aaatccactc tctattctta aggttgtgat gaagcagtgc aagaacatgc      480

aggagcgcat gctgtcccag ctggctgctg ctgagagcag gcaccgaaag gtgatcctag      540

accttgagga agaaaggcag cggcatgcac aggatacggc tgaaggagat gatgtcacct      600

acatgctaga gaaggaaaga gagaggctga ctcaacagtt ggaatttgaa aaatcccaag      660

tgaaaaagtt tgaaaaagaa cagaagaagc tctctagtca gctggaagag gagcgctccc      720

gccacaagca gctctcatcc atgctagtgc ttgagtgcaa gaaagccacc aacaaggcag      780

ccgaggaagg acagaaggca ggagagctga gcctgaaatt ggagaaggag aagagccggg      840

tgagtaaact ggaagaagag ttggcagctg agagaaagag aggcttgcag actgaggccc      900

aggtagagaa gcagttatca gagtttgaca tcgaaaggga acaactgaga gcaaaactga      960

accgagaaga gaaccggacc aaaaccctga aagaagaaat ggaaagttta aaga           1014


<210> 3329
<211> 3615
<212> DNA
<213> Homo sapiens

<400> 3329
gggagccggg aggcagcgga ggagcgaccg ccgccatatt agggaccgcg gagcccggga       60

tcccgtcagc ggcggccgcg gccgggcctg cgggagctgc ggaggccgga ggcgggcgct      120

gtgcggtgcc aggagaggcg gggtcggcgg gagccagcga gccacgggag cgagccaggc      180

taaccttgcc gcgggccgag ccctgcctcg ccatggacca ggactatgag cggcgcctgc      240

ttcgccagat cgtcatccag aatgagaaca cgatgccacg cgtcacagag atgcggcgga      300

ccctgacgcc tgccagctcc ccagtgtcct cgcccagcaa gcacggagac cgcttcatcc      360

cctccagagc cggagccaac tggagcgtga acttccacag gattaacgag aatgagaagt      420

ctcccagtca gaaccggaaa gccaaggacg ccacctcaga caacggcaaa gacggcctgg      480

cctactctgc cctgctcaag aatgagctgc tgggtgccgg catcgagaag gtgcaggacc      540

cgcagactga ggaccgcagg ctgcagccct ccacgcctga gaagaagggt ctgttcacgt      600

attcccttag caccaagcgc tccagccccg atgacggcaa cgatgtgtct ccctactccc      660

tgtctcccgt cagcaacaag agccagaagc tgctccggtc cccccggaaa cccacccgca      720

agatctccaa gatccccttc aaggtgctgg acgcgcccga gctgcaggac gacttctacc      780

tcaatctggt ggactggtcg tccctcaatg tgctcagcgt ggggctaggc acctgcgtgt      840

acctgtggag tgcctgtacc agccaggtga cgcggctctg tgacctctca gtggaagggg      900

actcagtgac ctccgtgggc tggtctgagc gggggaacct ggtggcggtg ggcacacaca      960

agggcttcgt gcagatctgg gacgcagccg cagggaagaa gctgtccatg ttggagggcc     1020

acacggcacg cgtcggggcg ctggcctgga atgctgagca gctgtcgtcc gggagccgcg     1080

accgcatgat cctgcagagg gacatccgca ccccgccact gcagtcggag cggcggctgc     1140

agggccaccg gcaggaggtg tgcgggctca agtggtccac agaccaccag ctcctcgcct     1200

cggggggcaa cgacaacaag ctgctggtct ggaatcactc gagcctgagc cccgtgcagc     1260

agtacacgga gcacctggcg gccgtgaagg ccatcgcctg gtccccacat cagcacgggc     1320

tgctggcctc ggggggcggc acagctgacc gctgtatccg cttctggaac acgctgacag     1380

gacaaccact gcagtgtatc gacacgggct cccaagtgtg caatctggcc tggtccaagc     1440

acgccaacga gctggtgagc acgcacggct actcacagaa ccagatcctt gtctggaagt     1500

acccctccct gacccaggtg gccaagctga ccgggcactc ctaccgcgtg ctgtacctgg     1560

caatgtcccc tgatggggag gccatcgtca ctggtgctgg agacgagacc ctgaggttct     1620

ggaacgtctt tagcaaaacc cgttcgacaa aggagtctgt gtctgtgctc aacctcttca     1680

ccaggatccg gtaaacctgc cgggcaggac cgtgccacac cagctgtcca gagtcggagg     1740

accccagctc ctcagcttgc atggactctg ccttcccagc gcttgtcccc cgaggaaggc     1800

ggctgggcgg gcggggagct gggcctggag gatcctggag tctcattaaa tgcctgattg     1860

tgaaccatgt ccaccagtat ctggggtggg cacgtggtcg gggaccctca gcagcagggg     1920

ctctgtctcc cttcccaaag ggcgagaacc acattggacg gtcccggctc agaccgtctg     1980

tactcagagc gacggatgcc ccctgggacc ctcactgcct ccgtctgttc atcacctgcc     2040

caccggagcc gcatgctctt cctggaactg cccacgtctg cacagaacag accaccagac     2100

gccagggctg attggtgggg gcctgagacc ccggttgccc attcatggct gcaccccacc     2160

atgtcaaacc caagaccagc cccaaggcca gaccaaggca tgtaggcctg ggcaggtggc     2220

tcggggccac tggcggagcc agcctgtgga tccaagagac agtccccacc tgggcttcac     2280

ggcatccttg cagccacctc tgctgtcact gctcgaagca gcagtctctc tggaagcatc     2340

tgtgtcatgg ccatcgcccg gcggtcagtg ggcttcagat gggcctgtgc atcctggcca     2400

agcgtcaccc tcacactgga ggaggatgtc tgctctggac ttatcacccc aggagaactg     2460

aacccggacc tgctcactgc cctggctgga gaggagcaca acagatgcca cgtcttcgtg     2520

cattcgccaa cacgtgccct cacagggcca gcgtcctcct tccctgcgca agacttgcgt     2580

cccccatgcc tgctgggtgg ctgggtcctg tggaggccag cagcggtgtg gcccccgccc     2640

ccaggctgcc tgtgtcttca cctgtcctgt ccaccagcgc caacagccgt ggggaagcca     2700

aggagaccca aggggtccag gaggtgggcg ccctccatcc ttcgagaagc ttcccaggct     2760

cctctgcttc tctgtctcat gctcccaggc tgcacagcag gcagggaggg aggcaaggca     2820

ggggagtggg gcctgagctg agcactgccc cctcaccccc ccaccacccc ttcccatttc     2880

atcggtgggg acgtggagag ggtggggcgg gctggggttg gagggtccca cccaccaccc     2940

tgctgtgctt gggaaccccc actccccact ccccacatcc caacatcctg gtgtctgtcc     3000

ccagtggggt tggcgtgcat gtgtacatat gtatttgtga cttttctttg gatttgtttt     3060

gtgtttttgt tgactagtcc tggaaatgtt tgaggctaga cggggagggg ccaggaccca     3120

cccactgctc ctgggggatg aggtcctggt tttaaagccc cgtcatttca agcgggtcga     3180

tcttccacat tcactggaga gactctcccc acctctgtct gggtggggcg cggacccctc     3240

actgtgcgcc tgtgcagggg gtgctggtgc acgtggcagt gtggatttcc agtggtcacg     3300

gtcttactgt ttcaaggttt ttaaataaga aaaccaaccc tgccttcgcc catgcccgcc     3360

cctgcccgca gttgccaaag agccgccttg tcgctgtggg cgtcagggct tggctggctc     3420

agtgcacaac ccacagtggc cttcagaggc tcctcctggg actgggaacc gccgcagggc     3480

caggcggacg gcgtgaggtt tgtgttgggg ctggttctgc ccatgctagg gggtggggga     3540

gctcccagga cagaccagcc ttgtttctca tgtaatgcag tgacgctgtc attaaacacg     3600

tggattcatg tgtgg                                                      3615


<210> 3330
<211> 564
<212> DNA
<213> Homo sapiens

<400> 3330
gcggcagctg gaggatgaag aaggagcatg tgcttcactg ccagttctcc gcgtggtacc       60

cgttcttccg aggcgttacc atcaagagtg tcattcttcc acttcctcag aatgtgaagg      120

attatttact cgatgatgga actctggtgg tttcaggaag ggatgatcca ccaacacatt      180

ctcagccaga cagtgatgat gaagcagaag aaatacagtg gtctgatgat gagaacacag      240

ccacgcttac ggatgcgtat tggatagcaa tgaatagttc tctgaaatgt aaaaccctca      300

gcgacatctt tctgcttttc aagagttccg atttcatcac tcgtgacttc actcagccgt      360

ttattcattg tactgatgat tctccagatc catgtataga atatgagctc gttctccgaa      420

aatggtgtga attgattcct ggggctgagt ttcgatgttt tgtcaaggaa aacaagctta      480

ttggtatttc tcaaagagac tacacacaat actatgatca tatttctaaa caaaaggaag      540

aaattcgcag atgcatacaa gact                                             564


<210> 3331
<211> 4554
<212> DNA
<213> Homo sapiens

<400> 3331
ttcctgtgct ggatcctggg cggcctgagg gcccgcgggc cagcaccatg gaggacgtga       60

agctggagtt cccttccctt ccacagtgca aggaagacgc cgaggagtgg acctacccta      120

tgagacgaga gatgcaggaa attttacctg gattgttctt aggcccatat tcatctgcta      180

tgaaaagcaa gctacctgta ctacagaaac atggaataac ccatataata tgcatacgac      240

aaaatattga agcaaacttt attaaaccaa actttcagca gttatttaga tatttagtcc      300

tggatattgc agataatcca gttgaaaata taatacgttt tttccctatg actaaggaat      360

ttattgatgg gagcttacaa atgggaggaa aagttcttgt gcatggaaat gcagggatct      420

ccagaagtgc agcctttgtt attgcataca ttatggaaac atttggaatg aagtacagag      480

atgcttttgc ttatgttcaa gaaagaagat tttgtattaa tcctaatgct ggatttgtcc      540

atcaacttca ggaatatgaa gccatctacc tagcaaaatt aacaatacag atgatgtcac      600

cactccagat agaaaggtca ttatctgttc attctggtac cacaggcagt ttgaagagaa      660

cacatgaaga agaggatgat tttggaacca tgcaagtggc gactgcacag aatggctgac      720

ttgaagagca acatcataga gtgtgaattt ctatttggga aggagaaaat acaagagaaa      780

attataatgt aaaatggtaa aaacataagt agtttttttt tcaattacat gttgcttcca      840

gacatacttc tctgcaactt gttgagcaac attttaagat gttggacttc tgcaatagat      900

gacactgatg gttttactcc tttttttaaa aacacatgcg cgcgcacaca cacatgcttt      960

acaagtttta ttataaacca agaattttgg acttgcaaag aggtattatt gcaataatgc     1020

acttttcata cttgaaattt atttgtatga tataaagtta ttactttaaa caaaatgcaa     1080

gtatgggggg attgtttata aagtttgggt aatttataac aaaatttgct aaggtttgct     1140

aaaaattcat ttttctgttc tatatattac atttttaaca taattttaca gttcaatttt     1200

atgatggagc ctcttacaga aacattaaca aaatgcagga atctgccaca tttctttttt     1260

agtataactt aatagcttaa ttaccatttt attttttata cttcttccat tattaatctt     1320

taaatcatga tcctaattag ctgtccttac tttaacttga tctaattatt gcttcctttc     1380

ttattacttt cctaattttt ctatatttta aaaactacag tttccatgat aaaaggaaaa     1440

cgttttgatt tatagtacca agtgcttaaa cacaaggata gtgttagatt ttcgagtgac     1500

tttccttttt gcattttttg gcagtaaaag ccaaacgttg tatttgttct tttcagagtt     1560

gtccagccct tttttccttt gtccaaaatg attctaaata gaatctaata aaccaatgta     1620

gcattatttt tttctaaatg aagccccaaa aaagaaaagt gccttgcatc atttaaaaaa     1680

aataattaaa tcctcatggc ctctaaatta gtatgtagaa cactgaaaag ttcttaacat     1740

ttttgtgtaa tttcctttct ttttaaacca taaattagtt taaactgaaa gtacgaggct     1800

ggaagaaata ttagtaaatt atttggaata tagaatgttt actctttctt tttatgttgt     1860

cttaatgatt ctgtgagatt gttccggctc aaacagaagc ttttctttgg ggaaggtgat     1920

ttgtgggaga ctagtgtatt ttaaattagc attttaatcc attcttgaca ttcagttagt     1980

ccagatctgc cccataattt gctttagtaa agtcacttta tggatttttg gctatgtttt     2040

agtttgtgtg tataaaagtt ctaagaaaac atttttgcta ttttaagtat gtaagggaag     2100

agaggagtgt ttttaacttt ttatagttga tgactttagg gtagcacaaa caaaactcct     2160

ttgtatctaa cttttctcaa tcctctcttg aggtgcttta ctaatgggaa tgatttctgt     2220

atgttccctt ggtaccaaga ggtactatgc aaagtaacct attacaccaa gttacttgct     2280

ttgctttcct ctctatgatg tgataataca gtaaaagctt tcttacccag catagtggga     2340

gagtggagat taattaaaat tgttaattaa gagttaattc ctattgaccc aggtgatatt     2400

tctcttctga tttccctccc cttcccttct cttatcttac cactgtgaaa acagcatatt     2460

gttaatctcg ttgtcgtcca gtattctgct ttgtgattag gtcttttgat gtacagtggt     2520

ctagtggagt caagattcgc attgggtttt ctaaaattcc agttgataaa agttccagat     2580

aacacagctt tcctgtatat agatcactat tgggcaggtc agcaaagatc tcttacagtg     2640

taataataat ctatgatgct tcatttagca gaaactctgc ttaaaagaat cttcataata     2700

gtaagtttag gttttaaaaa cttgtttcat aaatatacat atatcctctc tagtagtctg     2760

gccaaaagaa cagattttgt tattgataat ttgtagctgg taattttcca cattttctat     2820

ccactgtaat ttttatgttg tcactgaagt gcctgcccag tactgtatat tacagtctct     2880

cacaaacact gggaaaaggg actgtcatca tcttgagtac tctgtgtgta tatatatata     2940

tatagataga tagatttttt tttttttttg agacagagtc tctaatgtca cccaggctgg     3000

agtacagtgg cacaatcttg gctcactgca acctccacct cctgggttca agtgattttc     3060

ctgcctcagc ctcccaagta gctggggtta gaggcacatg ccaccatgcc tggctaattt     3120

ttgtagtttt agtagagatg gggtttcacc atgttggcca ggctggtctc aaactcctga     3180

cctcaagtga tccacccacc tcggcctccc aaagtgctgg gattacaggc gtgagccact     3240

gcgcctggct gagtacaata ttaatgtaga caaaccatga agtttattat ttcatataag     3300

aacattacag gtttgttttt tcttgcatgt ctgtccacct aatgtttaag tagttctggt     3360

agctcttcct attctttatt ctatttgatt ccatttctgt gattctttta ttaccactga     3420

tgttttgtga tagttaacta tgataaattt aactgatcat gatttatctt ctagagtatt     3480

taaataatgt atgagtgacc acccaattcc aacattaaaa gtgtaatctg ggcccataat     3540

ttatagtgaa attgtatcaa aacataggga aactgtatta ctgtccattt tgaaaatatg     3600

aaacttgagt attgaaaata ttcaaacatg gaatggcagt attctaattt cagttagttg     3660

gttcatgtta atttcttacc tgttagatgt ttaaactgca gtgaccttta cttgtatcta     3720

ctctgtggtg gaaatgttaa accatgatag cttttgctac caactcaacc acttaacttt     3780

tagagcagtt ttggggagag tttatgcttc atctgagttt agaagtaatg tcagaaaatg     3840

ttaagcatgt ctgtattaag aaaatataag gtttctaatt gtcttattaa tatggtaatt     3900

caagtgaatt agaaatattt aactgcaatc ttgaattata aagttgagat atatatatat     3960

atgtatcaag atctcaactt gatgtaaagt aaatgagcag ttacctggcg gatttttttt     4020

tttttaaata actgatttaa tccataatcc cataacaaac atagcttcac ctcagtattt     4080

tctttctttc tttgttcaac agtgctccga taagggaatg ctagaaaata gatgagaagt     4140

actgaaagac cttttttttt aattgattag aaaagtaagt ctctagggtc tttgaatgct     4200

ggaatttttt tttttttttt tgtctttccc atctgtggca gctaaaacaa aaatcactca     4260

aaatattcag gtttacatgt tagctctctc tcatagggag ctgccatacc tcacagttca     4320

aagtgtattc tatagatcag taacattata ctgacatgta attgcaattt actatgcagc     4380

aaaaatgatt caagaagaaa aataacctac agtgtctgta tacctttgta tacacaattg     4440

cttaagttac tctgctttta acatttgtac ttggataaaa tgcttatgtc tgtataggaa     4500

tgtcacagtg caagatgctg ctagcccagg cacaaagtat taaaattatt ttgt           4554


<210> 3332
<211> 2494
<212> DNA
<213> Homo sapiens

<400> 3332
agtagaacgg cgaggcggtg tatcacgtgg ctcggggacg tgtcaggggc ggagcctccg       60

cagcccctgc ccgagttaaa accggagtgt gagagagaaa agcgcttcag tagcgagagg      120

ggctgagaaa gtggtgacac cgccggggtg cggagggagt ccctgaaact tctcccaaca      180

gccccagggc caatcttccc tcagcccact cccctcttcg ccagctccca ggtccccact      240

cctgtaccgg gggtggggtg gggagccagg cccgtctccc gctgggacac acacaggggc      300

cgggagcggg gacgggaccc ccgaggcggg ggggacgaac cgacagacag acggctgggc      360

gcccgcccca gcgggcaggc aggcaggagg aggcggaggc gggggtacga cggggagcac      420

tgggtctggg gagtttcctc tcaactatcg ggggagaaac tccccgcagc cggaggaaag      480

acccagacag tgttttcctc ccgggggccg tgctcccccg ccccgcgtag cggcggtcgc      540

cgccaccggc gcctccacct ctaccatctc ctctttctcc accacctcgg gccccggtgt      600

ccccggccag cactatgccc atcttactgt tcctgataga cacgtctgcc tctatgaacc      660

agcgcagcca tctgggcacc acctacctgg acacggccaa aggcgcggta gagaccttca      720

tgaagctccg tgcccgggac cctgccagca gaggagacag gtatatgctg gtcactttcg      780

aagagccgcc ctatgctatc aaggctggat ggaaagaaaa ccatgcaacg tttatgaatg      840

aattgaaaaa ccttcaggct gaaggactta cgactcttgg ccaatcccta aggacagctt      900

ttgatttatt aaatttaaat agattagtaa ctggcataga caactatggg caggtaggtt      960

gaataataag gtggcaaaat agttgatttt tcattttgtg gaaaaacaca gtccagtcca     1020

aaaactacat aacatgaaat gcaagtataa aacattccaa attaaaatag aatatgcaca     1080

ttgttcaaag gcaaaactct taccctacta tatatatttt acatccctca ttttttcccc     1140

ctctaaaatg cattggtatt caggattaga atctgaaact tttgctataa agttgacata     1200

cattggtttt aatcccttga aagttcagta aagacctaaa aggaaaagca tcctaccaca     1260

ccacactcat gttgtatgtg caactattat agtggcttag agacactagt tcgtgttctt     1320

cgtttctata ttagtaaaga tgttagagga aattaatctg tttgttgcat cagggtttaa     1380

tgtgaccatg ttgtataact attctgaaag gtaagaagtt tttcactgga gtacagtcac     1440

tggctgagaa catttaagtt ttcttttgaa gcatacacag ttaacaacta ttgcaggaag     1500

aactctgaat taaatttcag gcccagagtt ttgatttaaa ctccaaaccc ttggaaaaaa     1560

agactgctgg aaaatatgaa agaacccttc gtttcttaac ccccacaagt ccttttattg     1620

cacttacttt catgtatttg aggatgagag gagctttaaa tcaacaataa ttcactaagg     1680

aataatgcaa ggtggtctat tgtaacattt tatgatatta ttgccctgga aataaaagat     1740

actgaacaat gtataatgtt acatgtaaca aaggaatatt atttccaagg agctcagttc     1800

ttatgttgta gtgaaaagca ctattcctaa ttatatattg ggtatatgtt gtattttccc     1860

aagtcccaca gtccctagtt ttgtgagttt cgtacatttc agggaaattc tttctgtgac     1920

tacaactttt atttgcttcc tattgaagga aattgacttg tttctgtttt aggaaatttt     1980

aagcttctta gggataactt cagtgcttaa gtgtctttgg aaataactga atttagttct     2040

ataacattta aaatgtacac tgaaattcag agtgagctta ccaaattgaa cttccaacgt     2100

ttagttaggt aaatatgtac tttcttacca cattaatact tttatgtttt tcccatctct     2160

gctgctttta ttttgcaact tttaataatt taggtagatt tgcaatgaac tttttggttt     2220

gtttctgtaa aatagtagtg gatttccttc tcttttatat tcctttgtga tatgtagtgc     2280

aacacagtct tactgcttaa ggttttcatc cttacctctt tgagttcaaa gagatattta     2340

aaacttgcca ttatttggtt acctttattt ggttgtcatg ttgttagtgt atggcagaac     2400

tattagtttc ctctttttct gcatcacatt tcataagtgg tcaaggcatt tggacatatt     2460

cacctcctat tacctattaa aaatacttct taaa                                 2494


<210> 3333
<211> 521
<212> DNA
<213> Homo sapiens

<400> 3333
gtttattact actgaaggaa gaacgtgagt agatcagaaa agggagctca ggtaccttcc       60

agagagtgag acccagcgcc cttgtctcgc acccagtagg ctttcatccc cgccatggcg      120

gagctgatcc agaagaagct acagggagaa gtggagaaat atcaacagct acagaaggac      180

ttaagtaaat ccatgtcggg gaggcagaaa cttgaagcac aactaacaga aaataatatc      240

gtgaaagagg aactggccct gctggatggg tccaacgtgg tctttaaact tctgggtccg      300

gtgctagtca aacaggagct gggggaggct cgggccacag tagggaagag gctggactat      360

atcacagctg aaattaagcg atacgaatcc cagcttcggg atcttgagcg gcagtcagag      420

caacagaggg agacccttgc tcagctgcag caggagttcc agcgggccca ggcagcaaag      480

gcaggggctc ctggcaaggc ctgaccccat ggtgggggga g                          521


<210> 3334
<211> 2722
<212> DNA
<213> Homo sapiens

<400> 3334
cgcgtctctt gtttgtgcgg ctgaccagtt ggcgacatgg tggcacccgt gctggagact       60

tctcacgtgt tttgctgccc aaaccgggtg cggggagtcc tgaactggag ctctgggccc      120

agaggacttc tggcctttgg cacgtcctgc tccgtggtgc tctatgaccc cctgaaaagg      180

gttgttgtta ccaacttgaa tggtcacacc gcccgagtca attgcataca gtggatttgt      240

aaacaggatg gctccccttc tactgaatta gtttctggag gatctgataa tcaagtgatt      300

cactgggaaa tagaggataa tcagctttta aaagcagtgc atcttcaagg ccatgaagga      360

cctgtttatg cggtgcatgc tgtttaccag aggaggacat cagatcctgc attatgtaca      420

ctgatcgttt ctgcagctgc agattctgct gttcgactct ggtctaaaaa gggtccagaa      480

gtaatgtgcc ttcagacttt aaactttgga aatggatttg ctttggctct ctgcttatct      540

tttttgccaa atactgatgt tacctggaag actggccagg tggaacgagg cagggcctgg      600

aagccaccag cctctctcgc cctctgtagc aggagctgcg actctatggt ttcatgttac      660

gcttccattc tgtgcaaggc tctgtggaag gagaagctgc acacattctg gcatcataac      720

agaatttcat ttcttccatc tgcattcagg ccaataccaa tattagcatg tggcaatgat      780

gattgcagaa ttcacatatt tgctcaacaa aatgatcagt ttcagaaagt gctttctctc      840

tgtggacatg aggattggat tagaggagtg gaatgggcag cctttggtag agatcttttc      900

ctagcaagct gttcacaaga ttgcctgata agaatatgga agctgtatat aaagtcaaca      960

tctttagaaa ctcaggatga cgataacata agactgaaag aaaatacttt taccatagaa     1020

aatgaaagtg ttaaaatagc atttgctgtt actctggaga cagtgctagc cggtcatgaa     1080

aactgggtaa atgcagttca ctggcaacct gtgttttaca aagatggtgt cctacagcag     1140

ccagtgagat tattatctgc ttccatggat aaaaccatga ttctctgggc tccagatgaa     1200

gagtcaggag tttggctaga acaggttcga gtaggtgaag taggtgggaa tactttggga     1260

ttttatgatt gccagttcaa tgaagatggc tccatgatca ttgctcatgc tttccacgga     1320

gcgttgcacc tttggaaaca gaatacagtt aacccaagag agtggactcc agagattgtc     1380

atttcaggac actttgatgg tgtccaagac ctagtctggg atccagaagg agaatttatt     1440

atcactgttg gtactgatca gacaactaga ctttttgctc catggaagag aaaagaccaa     1500

tcacaggtga cttggcatga aattgcaagg cctcagatac atgggtatga cctgaaatgt     1560

ttggcaatga ttaatcggtt tcagtttgta tctggagcag atgaaaaagt tcttcgggtt     1620

ttttctgcac ctcggaattt tgtggaaaat ttttgtgcca ttacaggaca atcactgaat     1680

catgtgctct gtaatcaaga tagtgatctt ccagaaggag ccactgtccc tgcattggga     1740

ttatcaaata aagctgtctt tcagggagat atagcttctc agccttctga tgaagaggag     1800

ctgttaacta gtactggttt tgagtatcag caggtggcct ttcagccctc catacttact     1860

gagcctccca ctgaggatca tcttctgcag aatactttgt ggcctgaagt tcaaaaacta     1920

tatgggcacg gttatgaaat attttgtgtt acttgtaaca gttcaaagac tctgcttgcc     1980

tcagcttgta aggcagctaa gaaagagcat gcagctatca ttctttggaa cactacatct     2040

tggaaacagg tgcagaattt agttttccac agtttgacag tcacgcagat ggccttctca     2100

cctaatgaga agttcttact agctgtttcc agagatcgaa cctggtcatt gtggaaaaag     2160

caggatacaa tctcacctga gttcgagcca gtttttagtc tttttgcctt caccaacaaa     2220

attacttctg tgcacagtag aattatttgg tcttgtgatt ggagtcctga cagcaagtat     2280

ttcttcactg ggagtcgaga caaaaaggtg gttgtctggg gtgagtgcga ctccactgat     2340

gactgtattg agcacaacat tggcccctgc tcctcagtcc tggacgtggg tggggctgtg     2400

acagctgtca gcgtctgccc agtgctccac ccttctcaac gatacgtggt tgcagtagga     2460

ttggagtgtg gaaagatttg cttatatacc tggaaaaaga ctgatcaagt tccagaaata     2520

aatgactgga cccactgtgt agaaacaagt caaagccaaa gtcatacact ggctatcaga     2580

aaattatgct ggaagaattg cagtggaaaa actgaacaga aggaagcaga aggtgctgag     2640

tggttacact ttgcaagctg tggtgaagat cacactgtga agatacacag agtcaataaa     2700

tgtgcactgt aatggactta at                                              2722


<210> 3335
<211> 2219
<212> DNA
<213> Homo sapiens

<400> 3335
cagcctctgc cgggttccgg gaaaaggagc tcctgctgcc actgctcttc cggagcctgc       60

agcatggggc ccctgccgcg caccgtggag ctcttctatg acgtgctgtc cccctactcc      120

tggctgggct tcgagatcct gtgccggtat cagaatatct ggaacatcaa cctgcagttg      180

cggcccagcc tcataacagg gatcatgaaa gacagtggaa acaagcctcc aggtctgctt      240

ccccgcaaag gactatacat ggcaaatgac ttaaagctcc tgagacacca tctccagatt      300

cccatccact tccccaagga tttcttgtct gtgatgcttg aaaaaggaag tttgtctgcc      360

atgcgtttcc tcaccgccgt gaacttggag catccagaga tgctggagaa agcgtcccgg      420

gagctgtgga tgcgcgtctg gtcaaggaat gaagacatca ccgagccgca gagcatcctg      480

gcggctgcag agaaggctgg tatgtctgca gaacaagccc agggacttct ggaaaagatc      540

gcaacgccaa aggtgaagaa ccagctcaag gagaccactg aggcagcctg cagatacgga      600

gagagaagtg gatgggccct atacctccag ccgtgaatgc cagactttaa gattgcccgg      660

aggaagcaaa ctcttcgtat aaaaaaagca ggccatctgc ttaacccttg gctccaccat      720

aaggcactgg gactcggatt tctctatctg atagagaaac tcccctggtc tctctatcag      780

caacagaaaa ccaagccaga tggactttgc aactaatcaa gtttgggatt tactgtcttc      840

tgaccaacca cagtgactga gatggggctg ggaccagaag cccagtggga gtgaacagcc      900

gagggaacca gagtctggct gagcttgtgg ccagatattt aaactgggtc cagccacacc      960

tgcaaaacca gggcaaggca gtaccgggaa actggctgga gttgctgcgg tttggggaag     1020

ttgcacaccc tttcatagat acctccctta accctcagtg cagattctga gaaaactcca     1080

aggcttctct gcctaaccta gtataacccc tgttccctac tacatacata taacttttcc     1140

attcccccag taattgaccc aaagtccctg cctctagctg tgcccattgt gcaatgatca     1200

gaatcccttg tttcaatagt attttgactt ctttaagaat actctgtatt tggaagctga     1260

aacctcactt ggatccattg ttgggaacca agtacggagc cttacatagc ccggaggagt     1320

ttcaggagca atgccacttt cccttccatc cctccctctg ggtctggctc ttcccatagt     1380

ccattttccc cttttatctc ccattaattt ctgtcttcct ctctcacctt ttccatgtct     1440

ctagcatcct ccaggattta aaatcatctt tacccaactt atctgtgaag taatggcaaa     1500

agaacatctc caaattaagt actccttttc ttcaaaggag tttcatggga tgtacagcta     1560

gtataaaata aaaatatggg aagatgtcca atcttaaaaa ccataagggc aaattaagac     1620

aaaactaagc tgcccagagc agggtgagtg gaaccagttt tatgaataaa gatgcttgtc     1680

tcagcactat atgtggatat caaaaattgt gaacaacttg aacacctatc aggaggagaa     1740

tactttaatc aattatggca cattcaggag ataatgtttt acagtcatca aaaattgtat     1800

atgagggcca gcacggtggc tcacacctgt aatcccagca ctttgggagg ccaaggcagg     1860

cggatcacct gaggtcagga gttcgagacc agactggcta acatggtaaa accctgtttc     1920

tactaaaaat acaaaaaagt aaccgggtgt ggtggcacgt gcctgtaatc ccagctactc     1980

gggaggctga ggcaggagaa tcgcttgaac ccgggaggca gaggttgtgg tgagctgaga     2040

ttgcactatt gcactccagc ttgggcaaca agagcgaaac tctgtctcaa aaaaaaattg     2100

tatttctgaa gaattgttaa gaacattgga aattcttgag atataatatt gattggaaaa     2160

agatgaaact atatggtatg atctcaatat gtcctgatga ataaaaacat aatacagag      2219


<210> 3336
<211> 1678
<212> DNA
<213> Homo sapiens

<400> 3336
aagagccgcg ccgcaggaga ggcaggctgg accgggggct ccccgggccc gcgacccccg       60

ccgtgacccc gcagccccca gctcgccccc aagatgatga agaggcagct gcaccgcatg      120

cggcagctgg cccagacggg cagcttggga cgcaccccgg agaccgctga gttcctgggt      180

gaggacctgc tgcaggtaga acagcggctg gagccggcca agcgggcagc ccacaacatc      240

cacaagcggc tgcaggcctg tctgcagggc cagagcgggg cagacatgga caagcgggtg      300

aagaagcttc ccctcatggc tctgtccacc acgatggctg agagcttcaa ggagctggac      360

cctgattcca gcatggggaa ggccttggag atgagctgtg ccatccagaa tcagctggcc      420

cgcatcctgg ccgagtttga gatgaccctg gagagggacg tcctgcagcc actcagcagg      480

ctgagtgagg aggagctgcc agccatcctc aaacacaaga aaagcctcca gaagctcgtg      540

tccgactgga acacactcaa gagcaggctc agtcaggcaa ccaagaattc aggcagcagt      600

caaggcctag gaggcagccc gggtagtcac agccatacga ccatggccaa caaggtggag      660

acgctgaagg aggaggagga ggagctgaag aggaaagtgg agcaatgcag ggacgagtac      720

ttggctgacc tgtaccactt tgttaccaag gaggactcct atgccaacta cttcattcgt      780

ctcctggaga ttcaggccga ttaccatcgc aggtcactga gctcgctgga cacagccctg      840

gctgagctga gggagaacca cggccaagca gaccactccc cttcgatgac agccacccac      900

ttccccaggg tgtatggggt gtcgctggca acccacctgc aagagctggg ccgggagatt      960

gccctgccca tcgaggcctg cgtcatgatg ctgctttctg agggcatgaa ggaagagggt     1020

ctcttccgtc tggctgctgg ggcctcggtg ctgaagcgtc tcaagcagac aatggcctcg     1080

gacccccaca gcctggagga gttctgctcc gacccgcacg ctgtggcagg tgccctcaag     1140

tcctatctgc gggagctgcc agagcctctg atgaccttcg acctctatga tgactggatg     1200

agggcagcca gcctgaagga gccaggggcc cggctgcagg ccctccaaga ggtgtgcagc     1260

cgcctacccc ccgagaacct cagcaacctc aggtacctga tgaagttcct ggcacggctg     1320

gccgaggagc aggaggtgaa caagatgaca cccagcaaca tcgccatagt cctgggaccc     1380

aacttgctgt ggccacctga gaaagaaggg ctggagtaca gtggcgcaat ctcggctcac     1440

tgcaacctcc gcctcccggg ttcaagcgat tcttctgcct cagcctgcca ggtagctggg     1500

actacaggga ccaggcccag ctggatgcag cctccgtgtc ttccatccag gtggtgggcg     1560

tcgtcgaggc gctgatccag agcgcagaca ccctcttccc tggagacatc aacttcaacg     1620

tgtcaggcct cttctcagct gttaccctcc aggacacagt cagtgacagg ctggcctc       1678


<210> 3337
<211> 570
<212> DNA
<213> Homo sapiens

<400> 3337
ctgtctcagc cagctgccct cctcctccaa gctggctcca cttctctaag cgccaacagc       60

gatggaaata aatagcatgt gtacagacgc ctggaccctt gagaaactca gaatatttct      120

gcatgccttc ctagctcctc tagcgctcta gaaggtgcct tggaatttgt gtcgctgagt      180

cagcaagcct ttcagatttg cccggttttt gttgtttgtg gtttgtatca agatgggaac      240

tcaaacaagt cattcctcct aaggagctgg tgtcttcatc cagaagggac agtttgtgcc      300

agctctccag agagaaaagg atctggtact gttctggagt ggcctgtagc agacactgaa      360

ccaccagcca gctgcatttg ttgtcctgga agtcattgcc aactctgcca gtcacactgg      420

ggtccccaga gaagtcaaga tctgccggag gcgctgggca atgaccccgg gactccaggc      480

cagaggggtc tgaagctgtt tgggaaagca gcgggactcc ttgggaagat ggccatggcc      540

ccaagccctt ccctggtgca ggtgtacacc                                       570


<210> 3338
<211> 1831
<212> DNA
<213> Homo sapiens

<400> 3338
ggaagtacgg ccggaagccc gccatagagt ttagtggcca gagcgactct tcagggaggt       60

ggcaggaaag gcttggaaca gctgccggag gtgacggagc ggcggccccg cccggtgcgc      120

tggaggtcga agcttccagc tctggacatc ctgagcccaa gtcccccaca ctcagtgcag      180

tgatgagtgc ggaagtgaag gtgacagggc agaaccagga gcaatttctg ctcctagcca      240

agtcggccaa gggggcagcg ctggccacac tcatccatca ggtgctggag gcccctggtg      300

tctacgtgtt tggagaactg ctggacatgc ccaatgttag agagctggct gagagtgact      360

ttgcctctac cttccggctg ctcacagtgt ttgcttatgg gacatacgct gactacttag      420

ctgaagcccg gaatcttcct ccactaacag aggctcagaa gaataagctt cgacacctct      480

cagttgtcac cctggctgct aaagtaaagt gtatcccata tgcagtgttg ctggaggctc      540

ttgccctgcg taatgtgcgg cagctggaag accttgtgat tgaggctgtg tatgctgacg      600

tgcttcgtgg ctccctggac cagcgcaacc agcggctcga ggttgactac agcatcgggc      660

gggacatcca gcgccaggac ctcagtgcca ttgcccgaac cctgcaggaa tggtgtgtgg      720

gctgtgaggt cgtgctgtca ggcattgagg agcaggtgag ccgtgccaac caacacaagg      780

agcagcagct gggcctgaag cagcagattg agagtgaggt tgccaacctt aaaaaaacca      840

ttaaagttac gacggcagca gcagccgcag ccacatctca ggaccctgag caacacctga      900

ctgagctgag ggaaccagct cctggcacca accagcgcca gcccagcaag aaagcctcaa      960

agggcaaggg gctccgaggg agcgccaaga tttggtccaa gtcgaattga aaggactgtc     1020

gtttcctccc tggggatgtg gggtcccagc tgcctgcctg cctcttagga gtcctcagag     1080

agccttctgt gcccctggcc agctgataat cctaggttca tgacccttca cctcccctaa     1140

ccccaaacat agatcacacc ttctctaggg aggaggcaaa tgtaggtcat gtttttgttg     1200

gtactttctg ttttttgtga cttcatgtgt tccattgctc cccgctgcca tgctctctcc     1260

cttgtttcct taagagctca gcatctgtcc ctgttcatta catgtcattg agtaggtggg     1320

tagccctgat gggggtcgct ctgtctggag cataacccac aggcgttttt tctgccaccc     1380

catccctgca tgcctgatcc ccagttccta taccctaccc ctgacctatt gagcagcctc     1440

tgaagagcca tagggccccc acctttactc acaccctgag aattctggga gccagtctgc     1500

catgccagga gtcactggac atgttcatcc tagaatcctg tcacactaca gtcatttctt     1560

ttcctctctc tggcccttgg gtcctgggaa tgctgctgct tcaaccccag agcctaagaa     1620

tggcagccgt ttcttaacat gttgagagat gattctttct tggccctggc catctcggga     1680

agcttgatgg caatcctgga agggtttaat ctccttttgt gagtttggtg gggaagggaa     1740

gggtatatag attgtattaa aaaaaaaaag gtatatatgc atatatctat atataatatg     1800

acgcagaaat aaatctatga gaaatctatc t                                    1831


<210> 3339
<211> 3587
<212> DNA
<213> Homo sapiens

<400> 3339
aattcccaga gccggggctg gggctctagg ctgccgcggc ggctctaggc tgggctgctg       60

ggcgcgaggc cagggcgggc cgggagaggc tgcgccggcg gcggatcgcg cagagggcgg      120

tggcctgggc tggccgaacc atggcggccc cggagccggc gccgaggcgg gcccgggaac      180

gggagcggga gcgggaggac gagagcgagg acgagagcga catcctggag gaaagcccgt      240

gtggtcgctg gcaaaagcga cgggagcagg taaaccaagg gaacatgcca gggcttcaga      300

gcaccttcct agccatggac acggaggagg gggtagaggt ggtgtggaac gagctccact      360

tcggagacag gaaggccttc gcggcgcacg aggagaagat ccagaccgtg ttcgagcagc      420

tggtgctggt ggaccacccg aacatcgtga agttgcacaa gtactggctg gatacctctg      480

aggcctgcgc gagggtcatc ttcatcacag agtacgtgtc atcaggcagc ctcaagcaat      540

tcctcaaaaa gaccaagaag aaccacaagg ccatgaacgc ccgggcctgg aagcgctggt      600

gcacgcagat cctgtctgcg ctcagcttcc tgcacgcctg cagcccccca atcatccacg      660

ggaacctgac cagcgacacc atcttcattc agcacaacgg cctcatcaag atcggctccg      720

tgtggcaccg aatcttctcc aatgcacttc cagatgatct ccgaagcccc atccgcgctg      780

agcgagagga acttcggaac ctgcacttct tccccccaga gtatggagag gtggccgatg      840

ggaccgctgt ggacatcttc tcctttggga tgtgtgcgct ggagatggct gtactggaaa      900

tccagaccaa tggggacacc cgggtcacag aggaggccat tgctcgcgcc aggcactcgc      960

tgagtgaccc caacatgcgg gagttcatcc tttgctgcct ggcccgggac cctgcccgcc     1020

ggccctctgc ccacagcctc ctcttccacc gcgtgctctt cgaggtgcac tcgctgaagc     1080

tcctggcagc ccactgcttc atccagcacc agtacctcat gcctgagaat gtggtggagg     1140

agaagaccaa ggccatggac ctgcacgcgg tcttggcgga gcttccccgg ccccgcaggc     1200

ccccgctgca gtggcggtac tcggaagtct ccttcatgga gctggacaaa ttcctggagg     1260

atgtcaggaa tggaatctac ccactgatga actttgcagc cactcgaccc ctggggctgc     1320

cccgtgtgct ggccccaccc ccggaggagg tccaaaaggc caagaccccg acgccagagc     1380

cctttgactc tgagaccaga aaggtcatcc agatgcagtg caacctggag agaagcgagg     1440

acaaggcgcg ctggcatctc actctgcttc tggtgctgga agaccggctg caccggcagc     1500

tgacctacga cctgctccca acggacagcg cccaggacct cgcctcggag ctcgtgcact     1560

atggcttcct ccacgaggac gaccggatga agctggccgc cttcctggag agcaccttcc     1620

tcaagtaccg tgggacccag gcctgacccg gagccccagc cccaggggac catgccgggg     1680

tgctgcctgg gcaggccatg ttggggagac tccagcaccg tggggctgcc ctcctccatg     1740

cgcctgggag cacaaaggcc ccggtagtga aggaaccccc cgtctcctga gagtggggct     1800

gaccctgcct tgggcgccga ggggttgggg ggtgggtgtg ggggagccgt taggcctccc     1860

aggtccttag gatcagggtt gcccccagaa ccccttccca tatcctccat tctccgccct     1920

gagttcctac ccaggctgcc tggccggggc cactgcctcc tcagcatgca ggaggctgcc     1980

ctgtagggaa ccccagctct ggggcttggg ggtgagggtc agccctggac agacctctgc     2040

ccagggaact gctccatggg gtctgggaga gcagccatcc cctgctggca ccatagaccc     2100

acacaaggag cctgcacagc aagccagcgg tgacacacct gcaggtgtca ggcatggcac     2160

tgggcacaac agggacctgg caggagaaac agaccacaga gaggtctgga gttgaggctg     2220

ttgtcagcaa agcccctggt cccacacagc tctgccctag agccacctct ttgacccttt     2280

acccaccctg agaccagaac ttgcagcccc tctgcagatc tcctctggcc actgcagccc     2340

ctccaatggg ctttttctct catgcattcc ctggcctgga ggcgtcaggg accccacatc     2400

ctccctgctc ctcagactca cagcccctcc atgttacctc ccgcacctcc tccctggggc     2460

agctgctccc tgggcctctg aggatgtcag ctcctggctc cctgcctctc tcccactcca     2520

ctcctggctc agtcttagag atttctatgc cctcatggat tctacccctg ccttcctggc     2580

ctcttgattc ttggcttgcc tctcctccaa ttccaaactt agtgaaatgg ccttaagcat     2640

tttaaactgt atgtatacat tagcgcattc atgcctttct aaacgcattt caaatgtcaa     2700

ccaggaaggc acaccactgt attagtttta tactgccgct gtaaaattta ccacaaactt     2760

agtgacttaa cacaaattta ttgcaattct gtaggctgga agtctgacta tgggtctcac     2820

tggactagaa tcaaggctgg caggctgcct tccttcctgg aggttctagg ggagactctg     2880

tctcctgctc cttcaggctg ctggcagaat ccacatcctt tcggtggcag ggccaaggtc     2940

cccactttct tgctgactgt aaactaaggc cacttccagc ttgtagaggc tgcctacatt     3000

ccttggctct tggccccctc ctccatcttc agagctagca ggttcagtct gtgtcacgaa     3060

ccatttctct ggttccctgc agacaggaaa ggttgtccct aaggactcat gagattaggt     3120

tgggcccagc cagataatac atgataatct ccctcctcaa ggtttttaat attaaacaca     3180

tctgcaggac acattttgcc atgtaaacta acattcactg gttccaggga ttaaggaatg     3240

aacctctttt gttggggaag ggtggcattc tgctgaccac agcactccaa ccaaaagcca     3300

aaaaccaaag caagacttac taacgcatat caaataaatt aaaggtacaa aatcgtgaat     3360

ctcagttatc ttaaatattc caatactatt tacaaaatta ttcaaattct cacgccttcc     3420

aactcaaaat tagcaatcta aagtaatttc catatcctag atggaaaccc tcatgctaaa     3480

ctgtctgatt atgcatggtt ctaaatggtt tcagtggcaa atacataaca ttgtactact     3540

gattaaactg aacttaaaag catcaatacc accattgctg cacttaa                   3587


<210> 3340
<211> 657
<212> DNA
<213> Homo sapiens

<400> 3340
ttaactcttg gactttgttc catgtttata acttagtatt tcacgaacgc cccgcggtgt       60

ttgttcattt ttcccacaca taatggacca taaaggtcgg cttctttgct ttatgactcg      120

ttctgaacaa gtccttttcc gcgctgtgtc tcactttcct cttttgtaaa atggaaatat      180

taactctaga cgccggtctg attaggttgc tttgaagatc gaaccagatg agggaagcca      240

aatacttcat aggctgtaaa gtggtgaagc tgaactgcta ccgagttgct atttttttct      300

cctcctccct ctcaagctaa acgttcttta gatcttttgt gatttcttca ggtggtcttt      360

gcgactccct aggctccgac ctggaagaaa tcttttttac acttcccttt cacagagccc      420

tgcattttaa cttccctatc agaagcgaga aaaatagtta tcattttgag agggcttact      480

ctatgccaag ccctgagaaa actctttacg tggattatct cgtttaattt cacaacatcc      540

ttttaagttt tccatggaca cagcctagca gaaagacgca gccttcgtgc ttcgctgact      600

gctgaccact gacccaccgc cttgatgaca gcaccctcgt gtgccttccc agttcag         657


<210> 3341
<211> 1062
<212> DNA
<213> Homo sapiens

<400> 3341
gttgccatta ggggactcct gaggtcctat ctccaggctg cggtgactgc actttccctg       60

gagtggaagc tgctggaagg cggaccggcc gccatgtcca cgttcaggca ggaggacgtg      120

gaggaccatt atgagatggg ggaggagctg ggcagcggcc agtttgcgat cgtgcggaag      180

tgccggcaga agggcacggg caaggagtac gcagccaagt tcatcaagaa gcgccgcctg      240

tcatccagcc ggcgtggggt gagccgggag gagatcgagc gggaggtgaa catcctgcgg      300

gagatccggc accccaacat catcaccctg cacgacatct tcgagaacaa gacggacgtg      360

gtcctcatcc tggagctggt ctctggcggg gagctctttg acttcctggc ggagaaggag      420

tcgctgacgg aggacgaggc cacccagttc ctcaagcaga tcctggacgg cgttcactac      480

ctgcactcta agcgcatcgc acactttgac ctgaagccgg aaaacatcat gctgctggac      540

aagaacgtgc ccaacccacg aatcaagctc atcgacttcg gcatcgcgca caagatcgag      600

gcggggaacg agttcaagaa catcttcggc accccggagt ttgtggcccc agagattgtg      660

aactatgagc cgctgggcct ggaggcggac atgtggagca tcggtgtcat cacctatatc      720

ctcctgagcg gtgcatcccc gttcctgggc gagaccaagc aggagacgct caccaacatc      780

tcagccgtga actacgactt cgacgaggag tacttcagca acaccagcga gctggccaag      840

gacttcattc gccggctgct cgtcaaagat cccaagcgga gaatgaccat tgcccagagc      900

ctggaacatt cctggattaa ggcgatccgg cggcggaacg tgcgtggtga ggacagcggc      960

cgcaagcccg agcggcggcg cctgaagacc acgcgtctga aggagtacac catcaagtcg     1020

cactcctccg cgagccccat cgtcgcgcct gtggacgcct ag                        1062


<210> 3342
<211> 2226
<212> DNA
<213> Homo sapiens

<400> 3342
attgacaaac agagcggtcg cggcggcgac tctcggcgtg cggtgatagc caagccatgg       60

gagacaagaa gagccccacc aggccgaagc ggcagccgaa gccgtcctcg gatgagggtt      120

actgggactg tagcgtctgc accttccgga acagcgccga ggccttcaag tgcatgatgt      180

gcgatgtgcg gaagggcacc tccacccgat ccacattgtt tgaagttatt gtgagtgcct      240

cgaggaccaa ggaaccgttg aaatttccaa tttcaggaag gaaacctcga cctgtctccc      300

agttggttgc acagcaggtt actcagcagt ttgtgcctcc tacacagtca aagaaagaga      360

aaaaagataa agtagaaaaa gaaaaaagtg aaaaggaaac aactagcaaa aagaatagcc      420

ataagaaaac caggccaaga ttgaaaaatg tggatcggag tagtgctcag catttggaag      480

ttactgttgg agatctgaca gtcattatta cagactttaa ggagaaaaca aagtcaccgc      540

ctgcatctag tgctgcttct gcagatcaac acagtcaaag cggctctagc tctgataaca      600

cagagagagg aatgtccagg tcatcttcac ccagaggaga agcctcatca ttgaatggag      660

aatctcatta aagtttattt tctccaattt cttagtcact tctgtcctac catgcaaata      720

cacagattat gccaagaggt accacatttt catgacagat acattcatgc acaatccata      780

atttgagttt tacataaaat agaaatttgt tagaatttgt tagattttat tgcaatgatg      840

cctaccaaac atttccagac ttaacatttt ggtctctgca gttaagtgcc atgaaaatgt      900

ggttgaatta ttcattatgc agtgttattg gtaagtgtat tttcactttt agtttagtga      960

attctaacac ataattcttg aattctctac tattggcatg taacgaattt aaatttttta     1020

taacatagtg caagctgcct aaatatgtat tatttgagaa ttgtgaaaca gatagttata     1080

tgtatacaag tcaaagaaca acttaactat tgctgcaaca ggtttttctt aatggttatc     1140

ctcttaaata cacctgctgg tacttggtgt ggttaaatag gaaaattgtt attaaataaa     1200

gaatttgtat gaacctttgc caatgttttt gacacgtttt actaattatt gttcctgaat     1260

tatgtttctg gttttatcta ttttttgagg tttttttgtt tgcttatttt tcaaaacatt     1320

catttattgt aatgtttact agcggactag taaacaataa aacattgatt atttagcttt     1380

ataattcagg tttagtgcta ttgtcattga acactggtat tttctgtatc atataaaaca     1440

ttaaaattca aataattata agcatttggc aaaaacaaga gaaaagaaac ttgccatatt     1500

ttacaagctg caattttaga aaagctttaa cttaatgata gttttatcat tgttttcttg     1560

tcccaaactt atccagggcc atagaagtat gaatctaatt aaaacagaaa tgggaattat     1620

tgcacagaaa tgggaaataa ctaattttaa atcagtcaaa ttggcttctt attaaataca     1680

ataattctta tgaaaatcat agtaccctat tttcagacac agctgccagt ttacacattt     1740

ctcagtatcc tgaaaggaaa aaagtatagc cccacttata ctatgtaaaa ttaccaataa     1800

aatattttta tgactacaga ttttgcattt ttgtttacaa ctatttaaag agttttatgt     1860

tgtatttaga atttcaacct agaaaccaca cagtacttaa attctcctgg ggtctcctgc     1920

tttctcttaa ccatttgctt aatatatatc tacctaaagg agacttctga attgtaaatg     1980

aacttaaaaa tagaatgtgg atgcaaaata tcacataaga catcatgata acatttgaag     2040

aaaaaataaa actgtagacc ctaacagttg tgatatttgg tggtttcatg tggtaatgta     2100

attttctgtt taattacagt actttttaca ggcacagtgg tactgtcttt tttgtaagat     2160

gctagttgtg aaatacaatt aattgcatac agtaaaagtc tgtgattaaa acatttatat     2220

acctca                                                                2226


<210> 3343
<211> 2248
<212> DNA
<213> Homo sapiens

<400> 3343
gcagaactcg cacaagggac cttatttagg ttgcgcaggc gcccgctggc catttcgtct       60

tagccacgca gaagtcgcgt gtctagtttg tttcgacgcc ggaccgcgta agagacgatg      120

atgttgggca cggaaggtgg agagggattc gtggtgaagg tccggggctt gccctggtct      180

tgctcggccg atgaagtgca gaggtttttt tctgactgca aaattcaaaa tggggctcaa      240

ggtattcgtt tcatctacac cagagaaggc agaccaagtg gcgaggcttt tgttgaactt      300

gaatcagaag atgaagtcaa attggccctg aaaaaagaca gagaaactat gggacacaga      360

tatgttgaag tattcaagtc aaacaacgtt gaaatggatt gggtgttgaa gcatactggt      420

ccaaatagtc ctgacacggc caatgatggc tttgtacggc ttagaggact tccctttgga      480

tgtagcaagg aagaaattgt tcagttcttc tcagggttgg aaatcgtgcc aaatgggata      540

acattgccgg tggacttcca ggggaggagt acgggggagg ccttcgtgca gtttgcttca      600

caggaaatag ctgaaaaggc tctaaagaaa cacaaggaaa gaatagggca caggtatatt      660

gaaatcttta agagcagtag agctgaagtt agaactcatt atgatccacc acgaaagctt      720

atggccatgc agcggccagg tccttatgac agacctgggg ctggtagagg gtataacagc      780

attggcagag gagctggctt tgagaggatg aggcgtggtg cttatggtgg aggctatgga      840

ggctatgatg attacaatgg ctataatgat ggctatggat ttgggtcaga tagatttgga      900

agagacctca attactgttt ttcaggaatg tctgatcaca gatacgggga tggtggctct      960

actttccaga gcacaacagg acactgtgta cacatgcggg gattacctta cagagctact     1020

gagaatgaca tttataattt tttttcaccg ctcaaccctg tgagagtaca cattgaaatt     1080

ggtcctgatg gcagagtaac tggtgaagca gatgtcgagt tcgcaactca tgaagatgct     1140

gtggcagcta tgtcaaaaga caaagcaaat atgcaacaca gatatgtaga actcttcttg     1200

aattctacag caggagcaag cggtggtgct tacgaacaca gatatgtaga actcttcttg     1260

aattctacag caggagcaag cggtggtgct tatggtagcc aaatgatggg aggcatgggc     1320

ttgtcaaacc agtccagcta cgggggccca gccagccagc agctgagtgg gggttacgga     1380

ggcggctacg gtggccagag cagcatgagt ggatacgacc aagttttaca ggaaaactcc     1440

agtgattttc aatcaaacat tgcataggta accaaggagc agtgaacagc agctactaca     1500

gtagtggaag ccgtgcatct atgggcgtga acggaatggg agggttgtct agcatgtcca     1560

gtatgagtgg tggatgggga atgtaattga tcgatcctga tcactgactc ttggtcaacc     1620

tttttttttt tttttttttt ttctttaaga aaacttcagt ttaacagttt ctgcaataca     1680

agcttgtgat ttatgcttac tctaagtgga aatcaggatt gttatgaaga cttaaggccc     1740

agtatttttg aatacaatac tcatctagga tgtaacagtg aagctgagta aactataact     1800

gttaaactta agttccagct tttctcaagt tagttatagg atgtacttaa gcagtaagcg     1860

tatttaggta aaagcagttg aattatgtta aatgttgccc tttgccacgt taaattgaac     1920

actgttttgg atgcatgttg aaagacatgc ttttattttt ttgtaaaaca atataggagc     1980

tgtgtctact attaaaagtg aaacattttg gcatgtttgt taattctagt ttcatttaat     2040

aacctgtaag gcacgtaagt ttaagctttt ttttttttta agttaatggg aaaaatttga     2100

gacgcaatac caatacttag gattttggtc ttggtgtttg tatgaaattc tgaggccttg     2160

atttaaatct ttcattgtat tgtgatttcc ttttaggtat attgcgctaa gtgaaacttg     2220

tcaaataaat cctcctttta aaaactgc                                        2248


<210> 3344
<211> 344
<212> DNA
<213> Homo sapiens

<400> 3344
aaaacagggc tcactggatc cccttcatca ctgtgggacc tgctgcgaga aatgtttgtt       60

gtgtgctcta aagaacaact acaatcgggt gggaaatatt cacaccaggt ctgggcaccc      120

ttttcaccct tggcttctgg agctgccttc tgatttatct gtacctcaac cccggtgaca      180

tcgaatatgt gtttccaacc tagcgcagct gcagaaccta ccagcagttc cgattcatca      240

cctccaagct ccttaagatg cacagtcagg gcttcttgtc ctgttaaata ccaccccaac      300

cccaggcctc cactggagat taaaaacctt cattcaaagc caaa                       344


<210> 3345
<211> 7648
<212> DNA
<213> Homo sapiens

<400> 3345
agagcctcgg tggtttgcag cagtggaacc aggcaggccc agttgtgggt aggagaggcc       60

gtcacctgtt gaggcctccc ccccacaccc ccgcatcgcc ctgccctggc agagcccagc      120

ccccagtccc cggagagcgc gcctgaggac ggacggacgg acggacggac agacctaggg      180

acggagggcc aggggcaggg gagatccaag aggccccgcg ctggaatgca gttttctcgg      240

gcgagggaga ctttgcaccg gagtggaaaa tagtttgggg tggggtttcg caccgtcccc      300

tcctccccag ccccgggccc cctcccaggc gctttctggg agcttttaga actgcgctct      360

gaagtttcca gagagcgagg agcttttgcg gcaggcagag acaatggaag aaaatgaaag      420

ccagaaatgt gagccgtgcc ttccttactc agcagacaga agacagatgc aggaacaagg      480

caaaggcaat ctgcatgtaa catcaccaga agatgcagaa tgccgcagaa ccaaggaacg      540

cctttctaat ggaaacagtc gtggttcagt ttccaagtct tcccgcaata tcccaaggag      600

acacacccta ggggggcccc gaagttccaa ggaaatactg ggaatgcaaa catctgagat      660

ggatcggaag agagaagcgt tcctagaaca tctgaagcag aagtaccccc accacgcctc      720

tgcaatcatg ggtcaccaag agaggctgag agaccagaca aggagcccca aactgtctca      780

cagtcctcaa ccacccagtc tgggtgaccc ggtcgagcat ttatcagaga cgtccgctga      840

ttctttggaa gccatgtctg agggggatgc tccaacccct ttttccagag gcagccggac      900

tcgtgcgagc cttcctgtgg tgaggtcaac caaccagacg aaagaaagat ctctgggggt      960

tctctatctc cagtatggag atgaaaccaa gcagctcagg atgccgaatg aaatcacaag     1020

tgcagacaca atccgtgctc tcttcgtaag tgcctttcca cagcagctca ccatgaaaat     1080

gctggaatcg cccagtgtcg ccatttacat caaagatgaa agcagaaatg tctattatga     1140

attaaatgat gtaaggaaca ttcaagacag atcactcctc aaagtgtaca acaaggatcc     1200

tgcacatgcg tttaatcaca caccaaaaac tatgaatgga gacatgagga tgcagagaga     1260

acttgtttat gcaagaggag atggccctgg ggcccctcgc cccggatcta ctgctcatcc     1320

accccatgcg attccaaatt ccccaccgtc tactccagtg ccccattcca tgcccccctc     1380

cccgtccaga attccttatg ggggcacccg ctccatggtt gttcctggca atgccaccat     1440

ccccagggac agaatctcca gcctgccagt ctccagaccc atctctccaa gcccaagcgc     1500

cattttagaa agaagagatg tcaagcctga tgaagacatg agtggcaaaa acattgcaat     1560

gtacagaaat gagggtttct atgctgatcc ttacctttat cacgagggac ggatgagcat     1620

agcctcatcc catggtggac acccactgga tgtccccgac cacatcattg catatcaccg     1680

caccgccatc cggtcagcga gtgcttattg taacccctca atgcaagcgg aaatgcatat     1740

ggaacaatca ctgtacagac agaaatcaag gaaatatccg gatagccatt tgcctacact     1800

gggctccaaa acaccccctg cctctcctca cagagtcagt gacctgagga tgatagacat     1860

gcacgctcac tataatgccc acggcccccc tcacaccatg cagccagacc gggcctctcc     1920

gagccgccag gcctttaaaa aggagccagg caccttggtg tatatagaaa agccacggag     1980

cgctgcagga ttatccagcc ttgtagacct cggccctcct ctaatggaga agcaagtttt     2040

tgcctacagc acggcgacaa tacccaaaga cagagagacc agcgagaaaa tgatgaaaac     2100

cacagccaac aggaaccaca cagatagtgc aggaacgccc catgtgtctg gtgggaagat     2160

gctcagtgct ctggagtcca cggtgcctcc cagccagcct ccacctgtgg gcacctcagc     2220

catccacatg agcctgcttg agatgaggcg gagcgtggcg gaactcaggc tccagctcca     2280

gcagatgcgg cagctccagc tgcagaacca ggagttgctg agggcaatga tgaagaaggc     2340

cgagctggaa atcagtggca aagtgatgga aacaatgaag agactggagg atcccgtgca     2400

gcgacagcgc gtcctagtgg agcaagagag acaaaaatat cttcatgagg aagagaagat     2460

cgtcaagaag ttgtgcgagt tggaagactt tgttgaagac ttgaagaagg actccacggc     2520

agccagccga ttggttactc tgaaagacgt ggaagacggg gctttcctcc tgcgtcaagt     2580

gggagaggct gtagctaccc tgaaaggaga atttccaacc ttacaaaaca agatgcgagc     2640

catcctgcgc atagaagtgg aggccgtgcg gtttctgaag gaggagccac acaagctgga     2700

cagtctcctg aagcgtgtgc gcagcatgac agacgtcctg accatgctgc ggagacatgt     2760

cactgatggg ctcctgaaag gcacggacgc agcccaagcc gcacagtaca tggctatgga     2820

aaaggccaca gccgcagaag tcctgaagag tcaggaggag gcagcccaca cctccggcca     2880

gcccttccac agcacaggtg cccctggcga tgcgaagtcg gaagtggtgc ctttgtccgg     2940

catgatggtt cgccacgcgc agagctcccc tgtggtcatc cagccctccc agcactccgt     3000

ggccctgctg aaccctgctc agaacttgcc tcacgtggcc agctccccag ccgtccccca     3060

ggaagcaacc tccactctgc agatgtcgca ggctccgcag tccccacaga tacccatgaa     3120

tgggtctgcc atgcagagct tgttcattga agaaatccac agtgtgagtg ccaagaacag     3180

ggcagtgtct atcgagaaag cagaaaagaa atgggaggaa aaaaggcaaa atctggatca     3240

ctataatggg aaagagtttg agaagctcct agaagaagct caggccaata tcatgaagtc     3300

aataccaaat ctggagatgc cgccagccac aggcccactg ccaaggggag atgccccagt     3360

ggacaaggtg gaactttcag aagattctcc aaattcggaa caggacttgg aaaagctggg     3420

gggaaagtcg ccccctcctc ctccgccacc tcctcgtcga agctacctgc caggatcggg     3480

actcaccacc acgaggtcag gcgatgtggt ctacaccggc agaaaggaga acatcaccgc     3540

taaggcaagc agtgaagatg ctggaccaag cccacagacc agagctacaa aatatccagc     3600

agaggagcct gcttcagcct ggaccccatc cccaccgcct gtcaccacct cctcctcaaa     3660

ggatgaggag gaagaagaag aagaaggaga caaaataatg gcagaactcc aggcattcca     3720

gaagtgttcc tttatggatg taaattcaaa cagtcatgct gagccatccc gggctgacag     3780

tcacgttaaa gacactaggt cgggcgccac agtgccaccc aaggagaaga agaatttgga     3840

atttttccat gaagatgtac ggaaatctga tgttgaatat gaaaatggcc cccaaatgga     3900

attccaaaag gttaccacag gggctgtaag acctagtgac cctcctaagt gggaaagagg     3960

aatggagaat agtatttctg atgcatcaag aacatcagaa tataaaactg agatcataat     4020

gaaggaaaat tccatatcca atatgagttt actcagagac agtagaaact attcccagga     4080

aactgtgcct aaggccagtt tcggtttctc tggcattagt ccattagaag atgaaataaa     4140

caaagggtct aaaatctcag gcctgcaata ctctatacct gacaccgaga accagacgct     4200

gaattacgga aagacaaagg agatggaaaa gcaaaatacg gataagtgtc acgtttcctc     4260

tcacactaga ctaacagaat caagcgtgca tgattttaaa acagaagatc aagaggttat     4320

cacgacagat tttggccaag ttgttctaag acccaaggag gcaaggcatg ctaacgtgaa     4380

ccctaatgag gatggagaat caagttcaag ttctcccact gaagaaaatg cagccactga     4440

caatattgcc ttcatgatta ccgaaaccac tgtccaggtt ctttccagtg gggaggtgca     4500

tgatattgtt agccaaaagg gagaagacat acagacggtt aatatcgatg ccagaaaaga     4560

gatgaccccc cgacaagaag ggactgacaa tgaggatcca gtcgtgtgcc tggacaagaa     4620

accagtgatc atcattttcg atgagcccat ggacatccgg tctgcctata agagactttc     4680

aactatcttt gaggaatgtg atgaggaatt agagagaatg atgatggagg aaaagataga     4740

ggaggaggaa gaggaggaaa atggggattc tgtagtccag aataataaca cttcccagat     4800

gtctcataag aaggtggccc caggcaatct tagaaccgga caacaggtgg aaacaaagtc     4860

acagccacac tccctggcca cagagaccag aaacccagga ggacaggaaa tgaacagaac     4920

ggagctgaac aagttcagcc acgtggattc tccaaattcg gaatgcaagg gtgaggacgc     4980

gaccgatgac cagtttgaaa gccccaagaa aaagtttaaa ttcaaattcc ctaagaagca     5040

actcgccgct ctcactcaag ccattcgcac cggaactaaa acagggaaga agactttgca     5100

agtggtagtc tatgaagaag aggaagagga tggcaccctg aaacagcaca aagaagccaa     5160

gcgcttcgaa atcgctaggt ctcaacctga agacacccct gaaaacacag tgaggaggca     5220

agagcagccc agcatcgaga gtacatctcc gatttcaaga actgatgaaa ttagaaaaaa     5280

cacctacaga acattggata gcctggagca gaccattaaa cagctcgaaa atacaatcag     5340

tgaaatgagt cccaaagccc tagttgatac ctcatgttct tccaacagag attctgttgc     5400

aagttcatcc cacatagccc aagaggcctc tccccgaccc ttgctagttc cggatgaagg     5460

tcccactgcc ctagagcccc ctacgtcgat accttcagct tcacgtaagg gctccagcgg     5520

ggccccacag acgagcagga tgcctgtccc catgagtgcc aagaacagac ccggaaccct     5580

ggacaaaccc ggcaagcagt ccaaactgca ggatccccgc caatatcgtc aggctaatgg     5640

aagtgctaag aaatctggtg gggactttaa gcctacttcc ccctccttac ctgcttctaa     5700

gattccagcc ctttctccca gctctgggaa aagcagttct ctgccctctt ctagtggtga     5760

cagctctaac ctccctaatc cacctgctac taaaccatcg attgcttcta accctctcag     5820

cccccaaaca ggaccacctg ctcactctgc ctccctcatc ccttctgtct ctaatggctc     5880

tttgaagttt cagagcctca ctcatacagg taaaggtcac catctttcat tctcaccgca     5940

gagtcaaaat ggccgagcac cccctccttt gtcattttcc tcctcccctc cttctcctgc     6000

ctcctccgtc tcactgaatc aaggtgccaa gggcaccagg accatccata ctcccagcct     6060

caccagctac aaggcacaga atggaagttc aagcaaagcc accccatcca cagcaaaaga     6120

aacctcttaa aggtcaaatc ctattaggca caagtcggag ttacatttaa aaaaaattaa     6180

cagtctacaa caactgtttt cacaagagaa tgtaacatat tgctgtatcg tttgaggctt     6240

aatgctaaat atgtgctaaa tactggatta atagatttca gtaaagctcg ttcgttttgt     6300

ttggttttct ttttacctag ttgctatagt gtctacagtc tatactcaat acctataaaa     6360

tgcagtaagc atgtgttaca gaaagaggtt ctggtgggag agaaaggtgc gtgtgagaca     6420

ggagaattgt cttaagcata taaaacatgt atgattccag aattttagta tgttttgtat     6480

aaaactattt ttcattacgg agactagaag tgaacagaga attacacaag tgtgactata     6540

caaattgtaa aacagatact ataatatttc cttttatttt agtgttattt agctttatta     6600

cagatttcta tttttgtcaa aacttcatgg ttcctttcaa gatctttttt gccaaaacat     6660

tttgatacta tagcattgta catttgaaag tagtgttcta gactataaaa ccaatgaact     6720

tctacatgag ccctacagac aggcatgtgt agaaggcaat ttatcaaacc tattgcactg     6780

ccatgaaaag tgtgtataat aatttgctag cccaagcaag ctagttttct ttgcttgctt     6840

cttttctttc ttttttcctt cctttttttt ttttttttct tttttaacat gttgagattc     6900

tctagttgtt ttctttggcg tatctaaccc cttcttttgt tttctgagac ctggtaaccc     6960

acgctcttgc attgtggatt ttaaaatgta tactctgtac ggttctgtaa accgaaaaac     7020

ttttgtaaat atataaatat acatagacat aaaaatactg tatgtgacag cacatagagt     7080

agttttccca caccaaagtt aatttttatg catgctttaa aagtatatat cgggaccggc     7140

agaaatggaa gtatccatac atttttaaaa agcaacaagt ttgcacagct agagtgtttt     7200

tgtaaataaa tgtatttgta taacacagtc atgtaatata cagaactata agcagagact     7260

ttgcaaaact aaataaaggg ctgcatgctt attatttttt gtaccttgtc actataacta     7320

cttcctagtc aaagaacgaa atgtaactgt taccgagtta aatgtttttc cgctttgagg     7380

gatgtaacca catccactca gaggacacta cttttctgaa agctctgggg tgactaatga     7440

tgagttccta ataaattaat tgcaagtgtg gtgccttgga tgtggcctgt tggctcgctt     7500

tcttctctgt ggcttatcaa ggtgtagatg acagaaagca aacctggata cagagtttcc     7560

accctcagtt cctggagggg ctcttattat tttctctctt tttaaaaaac ttccagtaga     7620

agtaaagtgg aaataaaatg tctttatc                                        7648


<210> 3346
<211> 3382
<212> DNA
<213> Homo sapiens

<400> 3346
agtcgtgcga cgccgggcgg ttgcgtgtgg tgcgcggggg cgcgggctgc gtgtggcgcg       60

gggcggggcg cggctggtgc gcttgagaag cgatggcggc ggcctgaact cacctaacac      120

cgcagcagca accgggcccg gccaggttcg gcgttccgtg agtgaacgat ttagaaatct      180

ggactggcca gtgacctctg ggcttgccat tccagcctgg tataacctct ggctccatgg      240

gcagctactg gctcctacag accggatgaa gcagactgga gacacaagtg gagaaaacct      300

ccagctggca aatcctcaga gtgtaggcct ctggctgcca gtcctgccca gcctgcctca      360

tggagaggat gaattggctg agcagactgg cctcccgggg ccctgggcac cgtatacctc      420

aaggggccaa tctccaaacc ccagtcatgg ctgatcccga gacctgcctc atggtcttca      480

agaatcactg gtcccaggtg gtgcgaatcc tggagcggca aggccctcgg gcagctcctg      540

ggggtgcaga cgatctcagt gctgtgcgca accacactta ccagatgttg acactgctgg      600

cagaggaccg tgcagttccc tcggccccca caggccctgg gcccctgctg gagtttgctc      660

tgcacgagga tctgctgacc cgtgtgttga catggcagct gcaatgggat gagcttgggg      720

atggggtcga ggaacggcgg gctgagcaac tgaaactatt tgaaatgcta gtgagcgaag      780

ctcgccagcc actgttgcgg catggtccag ttcgtgaggc tctgctcacc ctgctggatg      840

cctgtggccg ccctgtgccc agtagcccag cactggatga aggcttggtg ctacttctca      900

gccagctgtg tgtttgtgtg gcccaggagc cttcattgct cgagttcttc ctgcagccac      960

ctcctgagcc tggagccgct ccccgtcttc ttctcttttc tcgccttgtc ccttttgtgc     1020

atcgagaggg caccctgggc cagcaggccc gtgatgccct acttcttctc atggctttgt     1080

cagctgggag ccccactgtg ggccgctaca tcgcggatca ctcttacttc tgcccggtgc     1140

tggccacagg gctcagtgcc ctgtactcat cactgcctcg aaagattgag gttccagggg     1200

atgattggca ctgtctgcga cgggaagact ggctgggagt gccagccctt gcactcttca     1260

tgagttccct ggagttctgc aatgcagtaa ttcaggtggc tcaccccctg gtgcagaagc     1320

agttggttga ttatatccat aatgggttcc tggtgcctgt catgggtcct gccttgcaca     1380

agacctctgt ggaggagatg atcgccagta ccgcctatct ggaacttttc ctacggagta     1440

tctcagagcc tgctttgctc cgtaccttcc tgcgattcct gttgttgcac cggcatgaca     1500

cccacaccat cctcgacacc ctcgttgctc gtattggcag taactcccgg ctctgcatgg     1560

tctctctgag tctcttcagg accctcctga acctcagctg tgaggatgtc ctgctgcagc     1620

tggttctcag gtatcttgtt ccatgtaacc acgttatgct gagccagaag ccggctgttc     1680

gtgatgtgga cctatatgga cgagcagctg acaagtttct ctccctaatc ccacgctgtt     1740

gtcggcacca cgcccccagc ccacctcgtc cagagcatgc ctcatgggca cgaggtcctg     1800

gaagcccaag tgtggactcc tcttctgtga cgacagtacc ccggccctcc acaccatctc     1860

gtctggctct cttcctgcgg cagcagagcc tgggtggctc tgagtctcca ggcccagccc     1920

cttgctcacc agggctttct gcatcccccg cctccagccc tggccgacgg cctacccctg     1980

cagaggagcc tggagagctg gaagacaatt acctggagta tctgcgtgag gcacgtcgtg     2040

gtgtggaccg ctgtgtccga gcctgccgta cctggtctgc cccctatgat ggcgagcggc     2100

cctctcctga gcccagtcct tttggctccc ggactaagaa acgcagccta ctgcctgagg     2160

aggacaggaa caacgtgggg gaaggggagg aggaagagct ggggaggagg gggcgggctg     2220

ggggtgcagg ggagggccct ggtcacctgc cccctcccca gctcaatgga gtgccaggat     2280

catggcctga gggggccaag aaggttcgtc tggtgccaaa ggagggagct ggggaactgc     2340

tagagggcat ctccgagggc atggcaggac tagagggctt tgggcaggag ctccgggagc     2400

tagaggtggc attgagcaat gggggaactg gctcagagtc ccccttagaa cctccactgc     2460

cccttgagga ggaggaggcc tacgagagct tcacctgtcc ccctgagccc cctggcccct     2520

tcctcagcag ccctttgcgg actctcaacc agctgccaag ccagcccttc actggcccct     2580

tcatggctgt gctctttgcc aaactcgaga acatgctgca gaactccgct ctttcctgct     2640

caacaccaac atggtcttcc agcccagtgt caagtccctg ctgcaggtgc tgggctctgt     2700

gaagaataag attgagaact ttgcggcttc ccaggaggac ttcccagcac tgctgtccaa     2760

agccaagaag tacctcattg cccgtggcaa gttggactgg gctgagggcc ctgcagcagg     2820

acctgcccca cgccgttctg atcccctagt gaagagccgg aggccatcct tgggggagtt     2880

actcctgcgg catgcacaca gtccaaccag ggcccggcag gcggcacaat tggtccttca     2940

gcctgggcga gacggagcag gacttggcct aagtgggggc tcccctgggg cttcaactcc     3000

agttctactc acccggggcg gggcccctga acgccaaggt gaggctcttc gagtcaagaa     3060

tgctgtctac tgtgcagtca ttttccctga atttctcaag gagttggctg ccatctccca     3120

ggctcatgcc gtcacctcgc ctttcttgtt ggagacttca gaggaaggat ctggccctct     3180

catctcaggc tgtgggcccc tcaatcctta actttcttcc atggacaatc agggccatgg     3240

gtggcccggg ctggggctag ggcacaggct cctttttatg tttggaggca gtggcaaaag     3300

gactttttaa tttatttcag atgaatgttt tatggagaac ttgttgcaat atgtataaaa     3360

gggaaatctc tattctgtgc tc                                              3382


<210> 3347
<211> 1624
<212> DNA
<213> Homo sapiens

<400> 3347
tttctgttgt gtagttctga ttttccgaac aggtgtttag atgatgaggg gttatattaa       60

gaaagtacta aagaatacgt cttatcacgt gaatcagtat ctttttattc aacatggatg      120

gagtgggagt ggagaccaat ctgttttata ttcctgcaat ctgatgagga tggtcacaag      180

aacaaagaaa atatttgtag gcgggttatc tgcgaacaca gtagtggaag atgtaaagca      240

atatttcgag cagtttggca aggtggaaga tgcaatgctg atgtttgata aaactaccaa      300

caggcacaga gggtttggct ttgtcacttt tgagaatgaa gatgttgtgg agaaagtctg      360

tgagattcat ttccatgaaa tcaataataa aatggtagaa tgtaagaaag ctcagccgaa      420

agaagtcatg ttcccacctg ggacaagagg ccgggcccgg ggactgcctt acaccatgga      480

cgcgttcatg cttggcatgg ggatgctggg atatcccaac ttcgtggcga cctatggccg      540

tggctacccc ggatttgctc caagctatgg ctatcagttc ccaggcttcc cagcagcggc      600

ttatggacca gtggcagcag cggcggtggc ggcagcaaga ggatcaggct ccaacccggc      660

gcggcccgga ggcttcccgg gggccaacag cccaggacct gtcgccgatc tctacggccc      720

tgccagccag gactccggag tggggaatta cataagtgcg gccagcccac agccgggctc      780

gggcttcggc cacggcatag ctggaccttt gattgcaacg gcctttacaa atggatacca      840

ttgagcaggt gctttcgttg ccatctcact ctgagagcat acctggatgt ccaggcaaga      900

ctgggcgaag tttctgagtg gccctttgtt taggtgatgt cctcagacct ggacccccac      960

cagcctcact ccccatccca accagagatg gctcacttcg gatcgagggt tgactacatc     1020

tcatcatctc acgaatctgc tgtaatataa gacaacagct tttaaatgtg tatataaccc     1080

atgatttcgg ttttgttttg ttttgttttt cttgatggtt tccctctccc tccctctctt     1140

cccattctcc ttttaaatct ctttgaatca catttggtag tgattttgac ttagtccagt     1200

agtcacatag ctttaatatc tagttcaaag ctaaccatag tataattgtt atattaagga     1260

gttatttttt cttaaaacat ttttttttgc ttgttttggt tctgttctca cttttaaagg     1320

atgctgagat ggtaatatga ctctccatat tttggtacca attctgagac tgtatgaatt     1380

ttcaggtgga actttagcac acactgaagc aaagttgtga agtgcagggc gggaggtggg     1440

cgtgagcttt ctattttgcg ttgtagaaga agtgagatgt agtaagctaa ttaacagact     1500

ttctagcagt tctttttgtg atgtctcttt gttaatctga gtctatctat tttcggcaat     1560

aaggtaagga cgacagtgtt ttgagtgtcc tccttttcta taagtgcttt ttttctgttg     1620

aaag                                                                  1624


<210> 3348
<211> 615
<212> DNA
<213> Homo sapiens

<400> 3348
attaggaaga gtagccaggg aagtggaaac ttcaggctac cccctgggct tggagccctg       60

agtctgtccc caggggctga cttcctgcat tcctctaggg agttcctgac agctggattc      120

tagaagtaga actatgagct cacctttggc ctcccttagc aagacccgaa aagtgcccct      180

gccctcggag cctatgaatc ctgggaggcg aggaatccgc atctatggag atgtccctgc      240

atcccatgac tcggagctga tggccttcat gacgaggaag ttgtgggacc tggagcagca      300

ggtgaaggcc cagactgatg agatactgtc caaggatcag aagatagcgg ccctagagga      360

cctggtgcag accctccggc cacacccagc cgaggcaacc ctgcagcggc aggaggaact      420

ggagacgatg tgtgtgcagc tgcagcggca ggtcagggag atggagcggt tcctcagtga      480

ctatggcctg cagtgggtgg gcgagcccat ggaccaggag gactcagaga gcaagacagt      540

ctcagagcat ggcgagaggg actggatgac agccaagaag ttctggaagc cagggggact      600

cattggcgcc ccctg                                                       615


<210> 3349
<211> 782
<212> DNA
<213> Homo sapiens

<400> 3349
ttcagtgcag tcaccggcac agcagcaggt acctgccaga cctggggctc cctctgttca       60

agtgccatct ccttttctac ttcaaaacca atatgagcct gttcagcccc actggtttta      120

ctgcaaggag gtagaataca aacaactgtg gatgcctttt agtgtgttcg actctttgaa      180

tcttgaagaa atctataatt cagttcagcc agatccggag agcgtggttc ttggcacgga      240

tggagggcgc tacgatgttt acctctatga ccgaataagg aaggctgcct actgggaaga      300

ggagccagcc gaagtgagac gctgtacttg gttttacaag ggggacacag atagtcgatt      360

tattccctat actgaggagt tcagtgaaaa actagaggta cgggtgcttt atttctttat      420

gagtttcttt aaaaaatgta ggtcctatat acattggtga gtaacatcat tcacagtgga      480

gcggacttta cttacaagac agcttgtttt gatgctgttc acagagaaga ttacttttta      540

agtggtgtca tcactcatga ggtgctaatc gtggcatctg tgtctaaaga tagaatatga      600

tttgcagaga cacatcacag atctaataag gtgcttgtgt caagccttca atagaaccta      660

ggccgctggg atttgttgtt gatagaagat gccaagcata tggacatttt caaattagta      720

ttcagtaaaa ggcttgaaat taacctctga tttgtgaaaa taaataaata gaattggaag      780

aa                                                                     782


<210> 3350
<211> 1544
<212> DNA
<213> Homo sapiens

<400> 3350
ctgagctcct gtgtgtagag cgttgtgctc ggtgctgttt gcaagggaat caaagaagta       60

ggagatgata cttcctcttc ttgacagcct tatggttaag gtaagaagaa agcagcggca      120

ttgttcgaca gccaggcccc aatttgcccc atctgccagg tcctgctgag gcccagtgag      180

ctgcaggagc atatggagca ggaactggag cagctagccc aactgccctc gagcaagaat      240

tcccttctga aggatgccat ggctccaggc accccaaagt ccctcctgtt gtctgcttcc      300

atcaagaggg aaggagagtc tccaacggca tcaccccact catctgccac cgatgacctc      360

caccattcag acagatacca gacctttctg cgagtacgag ccaaccggca gacccgactg      420

aatgctcgga ttgggaaaat gaaacggagg aagcaagatg aagggcaggt atgtcccctg      480

tgcaaccgcc ccctggcagg atcggagcag gagatgagta ggcatgtgga gcattgcctt      540

tctaagaggg aaggctcctg catggctgag gatgatgctg tggacatcga gcatgagaac      600

aacaaccgct ttgaggagta tgagtggtgt ggacagaagc ggatacgggc caccactctc      660

ctggaaggtg gcttccgagg ctctggcttc atcatgtgca gcggcaaaga gaacccggac      720

agtgatgctg acttggatgt ggatggggat gacactctgg agtatgggaa gccacaatac      780

acagaggctg atgtcatccc ctgcacaggc gaggagcctg gtgaagccaa ggagagagag      840

gcacttcggg gcgcagtcct aaatggcggc cctcccagca cgcgcatcac acctgagttc      900

tctaaatggg ccagtgatga gatgccatcc accagcaatg gtgaaagcag caagcaggag      960

gccatgcaga agacctgcaa gaacagcgac atcgagaaaa tcaccgaaga ttcagctgtg     1020

accacgtttg aggctctgaa ggctcgggtc agagaacttg aacggcagct atctcgtggg     1080

gaccgttaca aatgcctcat ctgcatggac tcgtactcga tgcccctaac gtccatccag     1140

tgttggcacg tgcactgcga ggagtgctgg ctgcggaccc tgggtgccaa gaagctctgc     1200

cctcagtgca acacgatcac agcgcccgga gacctgcgga ggatctactt gtgagctatc     1260

tgccccaggc aggcctcgcc tccagcagcc ccacctgccc ccagcctctg tgacagtgac     1320

cgtctccctt tgtacatact tgcacacagg ttccccatgt acatacatgc acatactcaa     1380

acatgcgtac acacacacac atttacacac gcaggactct ggagccagag tagaggctgt     1440

ggcccaggca ctacctgctg gctcccacct atggtttggg ggccatacct gttccagctc     1500

tgttcccagg gtggggcagg gaggtggggg ttgggggagt agtg                      1544


<210> 3351
<211> 2744
<212> DNA
<213> Homo sapiens

<400> 3351
gcggcgccgg gcttcccacg gacggggccc cgcggggttg cccggccgtg cccgctgtgc       60

ccggctctgc ccggcgcggc cgcggagcgc acgcctcctg cctgctgacc ctctcgtttg      120

gtttctcgca ggcctctgcc gcagacatgg agaaactcag cgcgctgcag gagcagaagg      180

gcgagctgcg caagcggctg tcctacacca cacacaagct cgagaagctc gagaccgagt      240

tcgactccac gcgccactac ctggagatcg agctgcggcg cgcgcaggag gaactggaga      300

aggtcacgga gaagctgcgc aggattcaga gcaactacat ggcactgcag aggatcaacc      360

aggagctgga ggacaagctg taccgcatgg gccagcacta tgaggaggag aagcgtgcgc      420

tgagccacga gattgttgcc ctcaacagcc atctgctaga agccaaggtg accatcgaca      480

agctgtcaga ggacaacgag ctctatagga aggactgcaa tctagcggcc cagctgctgc      540

agtgcagcca gacctacggc agggtccaca aggtgtctga gctgccctcg gatttccagg      600

agcgcgtgag cctgcacatg gagaagcacg gctgcagcct gccatccccg ctctgccacc      660

cggcctacgc cgacagcgtc cccacctgcg tcattgccaa ggtgctggag aagccggacc      720

ccgccagcct gtcctcccgc ctgtccgatg cctccgcccg cgacctggcc ttctgcgacg      780

gggtggagaa accaggcccg cggcccccct acaagggaga catctactgc agtgacacag      840

ccctctactg cccggaggag cggcggcgag accggcggcc tagcgtggac gcgcccgtga      900

ccgacgtggg cttcctgcgg gcccagaact ccactgacag cgcggccgag gaggaggagg      960

aggccgaggc ggcggccttc ccggcgggct tccagcatga ggccttcccc agctacgcag     1020

gctcactgcc cacgtccagc tcctactcca gcttcagcgc cacgtcggag gagaaggagc     1080

acgcgcaggc cagcacgctg accgcgtcgc agcaggccat ctacctgaac agccgcgacg     1140

agctcttcga ccgcaagcca cccgccacca cctacgaggg cagccctcgc tttgccaagg     1200

ccacggccgc ggtggcggcc ccgctggagg ccgaagtggc cccaggcttc gggcggacca     1260

tgtcaccgta cccggccgag accttccgct tcccggcctc tccgggtccc cagcaggccc     1320

tgatgccccc aaacctgtgg agcctgcggg ccaagccggg gaccgcccgg ctccccgggg     1380

aggacatgag gggccagtgg cgtcccctga gcgtggagga catcggcgcc tactcctacc     1440

ccgtgagcgc tgccggccgc gcctcaccct gcagcttctc tgaacgctac tacggcgggg     1500

ccgggggcag cccgggcaag aaggccgacg gccgcgccag cccgctctac gccagctaca     1560

aggccgacag cttctccgag ggggacgacc tctcccaggg ccacctggca gagccctgct     1620

tcctgcgggc gggcggcgac ctgagcctca gtcccggccg ctcggctgac ccactgcccg     1680

gctatgcacc cagcgagggg ggggacgggg acaggctcgg ggtgcagctg tgtgggaccg     1740

ccagcagccc tgagcccgag cagggttcca gggactcctt ggagccgagc tccatggagg     1800

cctccccgga aatgcatcct gccgcccgcc tcagccccca gcaggccttt ccgcggactg     1860

gtggctcggg gctgagccgc aaggacagcc tcaccaaggc ccagctctac ggaaccttgc     1920

tcaactgagc gcctgcgtgc aggcctggcc gtggttcgct ccccgccagc ccacgtgccc     1980

cagaagggcc ggcctcacct ctccccagcc cccgctgttc ccctgccccg gccaacaacg     2040

aggagtctgt tcctccccgc acctcctctc ctccccagcc ctgtaggcct gaggggaggg     2100

tcccccacac cacggtgtcc acccggcccc ggcccgtgga actccactta gagcgttttt     2160

cacgcgtcct tcccccatgt gagaggagca tccccccttt tataaagcga aactattttt     2220

atagagaaaa agggtctttc ttaacgcact tggcctccag ctccctggac ggctgccttg     2280

gcgttttcaa cacaaagctc ctttattttt tgggcgaggg tgcgtggggc ctgccccttg     2340

gaagggaagg gaaggacggt gtcctgtgga gaccagactc tgcaagtggg gagaccaccc     2400

ccgcaagcca gtgacaaggg agccctgaag ttgtgtccac gaagagggag ctgaaacaaa     2460

ttcggggcta tgaagtgttt taaaaatcca ttcttcgcag tgtggccacc acaccgccct     2520

gagccctccc acggcccatc gtcccgggtg ggccgggatg atgccccagt gcggccggtg     2580

ctcatctccg cccccgggtc cgccccctga caccgtctta ctctacctca gacatgagga     2640

ggccctccat tcctggtttc tgtagcttgc attcttgttg tctctgatgc atgccctgcc     2700

agttagtact gtattttgca ttcattaata aaagacaccg gtgg                      2744


<210> 3352
<211> 456
<212> DNA
<213> Homo sapiens

<400> 3352
cttgcccttc agatctctga gaacttgttt agcaacaaag tcctcaatgc cttgaaacca       60

gaaaaagatg tggatggagt aacagacata aacctgggga agctggtgcg aggggatgcc      120

catgaatgtt ttgtttcacc tgttgccaaa gctgtaattg aacttcttga aaaatcaggt      180

gtcaacctag atggaaagaa gattttggta gtgggggccc atgggtcttt ggaagctgct      240

ctacaatgcc tgttccagag aaaagggtcc atgacaatga gcatccagtg gaaaacacgc      300

cagcttcaaa gcaagacgga gtctcgttct gtcaccaggc tggagtgcag gcgcgtgatc      360

taggctcact gcaagctctg cctcccaggt tgaagtgatt ctcctgtgaa agggaattat      420

ttttgatgag tcattaaagt atatccattc ccagaa                                456


<210> 3353
<211> 1533
<212> DNA
<213> Homo sapiens

<400> 3353
attggctgac aggtgatttc tggatgtcag gaacatttct gattaggaaa ccacagcttc       60

tccagggagt ctatgccatg ggcttcaatc gaccctccaa gatacaagag aacgcattac      120

ccatgatgct tgctgaaccc ccacagaatc tgattgccca gtctcagtct ggcactggta      180

aaacagctgc ctttgtctta gccatgctca gccgagtgga gccatcagac agataccccc      240

agtgtctgtg cctctcccca acatatgagc tggcgcttca aacaggaaaa gtgattgagc      300

agatgggcaa attttaccca gaactgaagc ttgcctatgc cgttcgaggc aataaattgg      360

aaagaggcca gaagatcagt gagcagattg tcattggcac ccctgggacc gtgctggact      420

ggtgctccaa gctcaagttc attgatccca agaaaatcaa ggtgtttgtt ctggatgagg      480

ctgatgtcat gatagccact cagggccacc aagatcagag catccgcatc cagaggatgc      540

tgcccaggaa ctgccagatg ctgcttttct ccgccacctt tgaagactct gtgtggaagt      600

ttgcccagaa agtggtccca gacccaaatg ttatcaaact gaagcgtgag gaagagaccc      660

tggataccat caagcagtac tatgtcctgt gcagcagcag agacgagaag ttccaggcct      720

tgtgtaacct ctacggggcc atcaccattg ctcaagccat gatcttctgc catactcgca      780

aaacagctag ttggctggca gcagagctct caaaagaagg ccaccaggtg gctctgctga      840

gtggggagat gatggtggag cagagggctg cggtgattga gcgcttccga gagggcaaag      900

agaaggtttt ggtgaccacc aacgtgtgtg cccgcggcat tgatgttgaa caagtgtctg      960

tcgtcatcaa ctttgatctt cccgtggaca aggacgggaa tcctgacaat gagacctacc     1020

tgcaccggat cgggcgcacg ggccgctttg gcaagagggg cctggcagtg aacatggtgg     1080

acagcaagca cagcatgaac atcctgaaca gaatccagga gcattttaat aagaagatag     1140

aaagattgga cacagatgat ttggacgaga ttgagaaaat agccaactga gaagctccac     1200

cagccactga tgccagccct ggcactgccc ctgcacagga gacaagtgca tttagggcac     1260

aggccccgac atcaccccaa ggacaacggc agaagtagag agaaactacc tacctcactt     1320

caaattatgt ttggacttga caaaaatagg tgcaaatgat ggggggcaat agaagaaaaa     1380

atttgcattt tggaaaattg ggtcctttcc ccactttttt aaagccacat tcccccatct     1440

ttataataat ctggtcacag tggtagtcgc tggccccagg accccctcct gattttggct     1500

aggcatcgtg gaaccagctc cagcccctga aga                                  1533


<210> 3354
<211> 5961
<212> DNA
<213> Homo sapiens

<400> 3354
ttgagacaat gttataatta taattgccct tcctttttgg ctgctgcttt agccagagcc       60

acatcagatg aagtccttca gagtgatctt tctgcacatt atatcccaaa ggaaacggat      120

ggcacagaag ggactgtgga gattgagaca gtgaaattgg cccgttctgt cttcagcaaa      180

ctacacgaga tttgctgcag ctgggtgaaa gacttccccc tccgcaggag accccagctt      240

tattatgaga catcaatcca tgccatcaaa aacatgcgca agctattcta taaacatata      300

agcaaaaaaa aaaaaaaaag aaagaaaaga gattgggacc aggaagaaca agcttacttt      360

gcagtgtttg atggccatgg gggagtagat gctgctattt atgcctccat tcacctccac      420

gttaacttag tccgccagga gatgttcccc catgatcctg ctgaggccct gtgcagggcc      480

ttccgggtca ctgatgagcg gtttgtgcag aaagcagcca gggagagctt aagatgtggg      540

accacaggag tggtgacttt catcagaggc aacatgctac atgtggcctg ggtgggtgat      600

tcccaggtta tgcttgtgag aaagggccaa gctgttgaac taatgaagcc acacaaacca      660

gacagagagg atgaaaagca gagaattgag gcccttggag gttgcgtagt ctggtttggt      720

gcctggaggg tgaatggaag tctgtcggtt tccagagcta ttggagatgc tgaacataag      780

ccatatatct gtggggatgc agattctgcc tccactgttc tggatgggac cgaagactac      840

ctcattctgg cctgtgatgg cttctatgac accgtgaacc ctgatgaggc agtgaaagtt      900

gtgtccgacc acctgaaaga gaataatgga gacagcagca tggttgccca caaattagtg      960

gcatcagctc gtgatgctgg gtcaagtgat aacatcacgg ttattgtggt attcctgagg     1020

gacatgaaca aagctgtaaa tgttagtgag gaatcagatt ggacagagaa ctcttttcaa     1080

ggagggcaag aagatggtgg ggatgataag gagaatcatg gagagtgcaa acgcccttgg     1140

cctcagcacc agtgctcagc accagccgac ctaggctatg atgggcgtgt ggattcattc     1200

actgatagaa ctagcctgag cccagggtcc caaatcaacg tgctggaaga cccaggctac     1260

ctagatctca cacaaataga agcaagcaaa cctcacagtg cccagttttt gctaccagtt     1320

gagatgtttg gtcctggtgc accaaagaaa gcaaatctta ttaatgagtt aatgatggag     1380

aaaaaatcag ttcagtcatc attgcctgaa tggagtggtg ctggagagtt tcccactgct     1440

ttcaatttgg gttcaacagg ggagcagata tacagaatgc agagcttgtc tcctgtctgt     1500

tcagggttgg aaaatgaaca gttcaaatcc ccgggaaaca gagtttctag attgtctcat     1560

ttacgccacc actactcaaa gaagtggcac agattcaggt ttaatccaaa gttttattca     1620

tttctctctg ctcaagagcc ttcccacaaa ataggcacta gcctgtcctc acttactgga     1680

agtgggaaga gaaataggat aagaagttct ctgccatgga ggcaaaatag ttggaaaggg     1740

tacagtgaaa acatgaggaa gctcagaaag actcatgata ttccatgccc agatcttcct     1800

tggagctata aaatagaata atttttcttt caagtaggtt agctagctct cccccaataa     1860

aaataccact atcagagtag aaacaaggta gacatttcta aaacatatgt gcttcattat     1920

gaatccatgg atggctcaat tcttaaatgt aaatagatct ctaggaaact caaagtacag     1980

tgttttcaat ctaaaaagaa gtattggcag tttcacttgc aaaattacac agctggtccc     2040

tgtgatgtgt ctcgacacca atacacaacc cccttcccac catccttcat gtcactagat     2100

acacaacccc cttcccacca tcccttcagt cactagtgga agctttcaag ttagttattt     2160

cagtcaggat atacagtgtt gaaatctcaa tgcagttgaa atctggtctg atgtgcctaa     2220

tttatctgtg gaaaatttaa tgctgaatta catttggttg ggaaatgtcc ctcaaaatcc     2280

tgggcactat gaaggaaccc cctgccccct cacctttttg ggtaggtaaa agactaaaag     2340

ccatatggat tttaactgat aacaatgaaa gtggtaaatc agtgtaaaag tgtcatattc     2400

tcagacttgt gaggcggttt atagtcagaa agatttacgg atttttttcc tgtaacataa     2460

aagattgtga acttttttta attaaaaaat atttcctagg gctgtagtta tttgggagtt     2520

tcataacctg ttatggtgct tttggtggaa atttttatta tttagcattt taggagaccg     2580

ctgtcaactg gttttaatct atgatgctaa tgtgttttcc actgtaccct catctcagga     2640

ataaaactgc tttaacggag atgatgtcag gtacaaatac actatagagt caaaatacca     2700

tttacaaaga aaatcaaaag catttctata ttttgtcttt ttttagttca gacagcaaag     2760

gcatgtacta ctataaaata caaagtgatt ttagagaatg aaaaatgcta cttttatctt     2820

ctctaaaatt atttccccca aggtagtgaa gtaattggaa tgaaggaggc tgaaagtatt     2880

gtctaaagtg agcccagagg ccactgagaa tgcagattac tgacagccag gtctgtttag     2940

ttgtaattgg aagacacatg agtgtcctgc ttacatgtag cttcagactg cagagacagg     3000

acgtgtgctt ttcatttcaa tatttagtta tatttgatat tttgaaactg tctgcttttt     3060

gctatttctg cagtttcaag ttagttagaa gcatgttgtc aactaaagac aacaaactat     3120

cagattcatt cattcagtga agcagcctct gattctctaa gagtcacgaa tgtcttagtg     3180

ttaccctccc ctagtcaaca gcagaccagc ctggccaatg cctatgggtg gcccctctgg     3240

agtgctcact aacaagggtg agtgctctcg ctaagaagtg tcccccgcct aatcatgtgt     3300

ttataggata gtacacgttc cccaggccca taacagagga ctaaaatctc tgaattttaa     3360

agacacagat gactggcata ttttggatac cagtatagct atatcaaata gacaaaaaca     3420

gcttcacttt agcaatgatc agattgttaa tctacagatt ttatttttta aaatttggat     3480

gtaagtagag actttcagta tttgttttct cttgattttg aagtcatttc ttcttctcac     3540

gtctgtgaca aatggttgaa aaggagtcaa catggcccca actatagtgc cggaaccttt     3600

tcatcattct gaggctttgc cccacacatg gtcctcactc atatctgtca ccttctgaag     3660

cctagatctt gttaacccat caggtgcagt gtcagtttca aatcaaatta tctaagaaaa     3720

caagaaaaca aaggcagcag actattggta cacattatag tccaaagtgc ttagcgaagt     3780

aaaaaaaaaa gctttttaaa atttctattg ttgtctattg gtaatgtttt tgatcagaat     3840

aaagagggta aagggaaaaa gttactacac atgctaggct ttctcagtgg ggaaaaaaat     3900

ggctggatag aactgggaca aacacagacc catctttagg ggtctggatt ttgtaggtcc     3960

gactacacag cagtgttaac tcatttctca tgccattagc tctctacaaa ataaagcaaa     4020

gtagttctag tgtggtcgtt ataaaccaat attgtgaaaa atagcaacta ttcatttgtt     4080

cacaacatgc gtatttatag agtagttagg taccatttgt aaggtaaatc ctttaaaatt     4140

ctataataca tactaaaata gtggttattg gtctgatata tgctgctctt ggttctataa     4200

actagataaa agcagtgctt tgtgaaatgc agtgttctct cttaacgcca ctggtgatag     4260

gaagtagttc ccttcagttc aaatcctgtg cccttatttg ctgcttgctg acgtaagcaa     4320

taagtaaccc tctaactaat ggtatctaca tatttctgta acttgtattt aatgatggtg     4380

tacctggtga ttgtaaaaat attagacaga tataaaagta tctatataat atctataaac     4440

tgttaatgct gaggtatagt ctgtgaatta tgtgttttgt atttttattc attgtgtaat     4500

ttagtggtgg tgaaagttct acactcaatc cttaaagagt ggcagtatcc ctttttcaat     4560

ttaacatggt ctgcatcaat ctgtttgcct gctaaacaag ttagaatagg aaatagtaaa     4620

ataaatccaa acaagagtgt aatattggtt agggaaacaa acttcaggtc accaactgaa     4680

gtcattacaa actccttgta cattcactgt gagtttcaaa gggagtcagt ccctaattta     4740

caggtttcct ttgttcactt tctagatgtg tacttttgag ggacatgagg ttaggcaaca     4800

ttacagcaac acacactggg gctattaatc ccatttaggt ctgtactaaa gaggatgggt     4860

agaaacacat atgtatatac cttttcttta cctagaagtg ccatccattg tccttgaatt     4920

attatgatta aagttactgt tgcatttagg aggctccttg aaagtaacac cttttccaag     4980

gacaatggca acaatgtcaa tgtcaacact gagtctaatt ttgaccacat ttatagtggt     5040

atagtgtcaa tactgcattt tcatgacaac cacactccac tgttgaaaca ctgtgccagt     5100

gagaagtgca acatccagtg ggcagatgaa aatgatgcat ggccaagttc agtgtttaca     5160

gataaaactg ctgtggttca agtgcttcct tccccatcaa atccttgata aggctttgtg     5220

ggaaaatgat ctaaattatt gttttaattt ttaaacctaa tttattcact cagtgaacat     5280

tcttacctaa gcaaggctat aaaagggaat actacagttt tgtccacact ttaatttgag     5340

accatttttc tttgaatcgt aagttagcaa aagaaatttt tttcaccttt gaaaatcacg     5400

tgatgttaaa ggacaaatgc ccactcttct attctgatct gcaaatagct taaatgtctc     5460

ttgcaaaaca aagtaagata ccaccagtat tacaacacaa tgattttcca gacaaatggt     5520

atggtgttga aaaataactg ttacttctta aagcagcatt ttatcttcta ttttgaagac     5580

tatttattgt aataattaga aaacatgaaa tagggaactc cagactgaca cagcagttgt     5640

ttttgaaaag gaaataaact ttgatgaatt agataatcca gatacatcat tgtaaactct     5700

tactctaggt gctctttggt gagagacagg ctttgttctc ttgttcataa catttctctg     5760

caaagaattc tctatggagt gaagcgaatg aagtgaataa tttcttacca aataaattta     5820

tcaatttaca aatctgctct acatctcact tttgagttca gttgtagtca tgagtgatcc     5880

ttcatatttt attaaaagtg ttcattcagg taaggtgtat gttgaaattt tgccaattat     5940

cttaataaaa cctggcaatt t                                               5961


<210> 3355
<211> 1085
<212> DNA
<213> Homo sapiens

<400> 3355
actcccagac tccttgcgga gctcgccgcc tgattctagg ctggtcacta ctccgagcct       60

gtgacgtttg cggcagccag gccgtcgacg atgcccagtg aaactctctg ggaaattgca      120

aaagctgaag tggaaaaaag gggaattaat ggaagtgaag gtgatggagc tgaaattgca      180

gaaaaatttg ttttcttcat tggcagtaaa aatgggggaa agactactat tattctaagg      240

tgtcttgaca gccaaaagat atcgctcact tttgggaact cggtggagga acctctttat      300

tggacttaat cagcataccc atcacaggtg acaccttacg gacgttttct cttgttctcg      360

ttctggatct ttcaaaacct aatgatctct ggcccaccat ggaaaatctc ttgcaagcca      420

caaaaagcca tgtagacaaa gtgataatga aactgggaaa gacaaatgct aaagcagttt      480

ctgaaatgag acagaagatc tggaataata tgccgaagga tcatcctgat catgaattaa      540

ttgacccatt tccggtacct ctggtcataa ttggaagtaa atatgatgtt tttcaggatt      600

ttgagtctga gaagagaaag gtaatatgca agacacttcg atttgttgca cattattatg      660

gagcatcatt aatgtttacc agtaaatcag aagctctatt actaaaaata cgtggagtta      720

tcaaccagtt ggcatttggc attgacaaaa gcaaatcaat atgtgtggat cagaataaac      780

cgctgtttat cacagcagga ttggattctt tcggtcaaat aggatctcct cctgttcctg      840

aaaatgacat tggaaagctt catgcccact cacctatgga gttgtggaaa aaagtgtatg      900

aaaagctctt tccaccaaag agtattaaca cgctgaaaga tatcaaggac cctgcgagag      960

atcctcagta tgctgaaaat gaagtcgatg agatgagaat tcagaaggat ctggaactgg     1020

aacagtacaa aagaagttct tccaagtctt ggaaacaaat cgagcttgat tcttgaacct     1080

atttc                                                                 1085


<210> 3356
<211> 932
<212> DNA
<213> Homo sapiens

<400> 3356
cgccgctgaa ggtacgcgtg agggcctgcg ctggagccgg cttgacaggt cggcttaccc       60

gctggccgcc tcctgacaag cgggagggat ccgcggtgga cccagggaag cggaggagcc      120

tggcggccac cccctcttcc tcacttccct gtactctcat cgctctcggc ctccgacacg      180

aaaaggaagc aaatgagctg atggaagatc tgtttgaaac tagacagggt cttgccatgt      240

tctggaactc ataggctcaa gtaatcttcc tgcctcaacc tcccaaagtg ctggaattac      300

agttccaaga tgagatggga ttctccaaca tggaagatga tggcccagaa gaggaggagc      360

gtgtggctga gcctcaagct aactttaaca cccctcaagc tctacggttt gaggaactac      420

tggccaacct actaaatgaa caacatcaga tagcgaagga actatttgaa cagctgaaga      480

tgaagaaacc ttcagccaaa cagcagaagg aggtagagaa ggttaaaccc cagtgtaagg      540

aagttcatca gaccctgatt ctggacccag cacaaaggaa gagactccag cagcagatgc      600

agcagcatgt tcagctcttg acacaaatcc accttcttgc cacctgcaac cccaatctca      660

atccggaggc cagtagcacc aggatatgtc ttaaagagct gggaaccttt gctcaaagct      720

ccatcgccct tcaccatcag tacaacccca agtttcagac cctgttccaa ccctgtaact      780

tgatgggagc tatgcagctg attgaagact tcagcacaca tgtcagcatt gactgcagcc      840

ctcataaaac tgtcaagaag actgccaatg aatttccctg tttgccaaag caagtggctt      900

ggatcctggc cacaagcaag gttttcatgt at                                    932


<210> 3357
<211> 615
<212> DNA
<213> Homo sapiens

<400> 3357
cacctcgctc agcagggcct ctcaggggtc ctcagtctgg cccaaggacc agggcctcag       60

cctagcccca agagtgggcc acaaccttca gcttcctgct gggaaaaccc aggagaaaca      120

aggagaccag tgctggtcca gtggctgtga tgggaaaaga ttattacaag attcttggga      180

tcccatcggg ggccaacgag gatgagatca agaaagccta ccggaagatg gccttgaagt      240

accacccaga caagaataaa gaacccaacg ctgaggagaa gtttaaggag attgcagagg      300

cctatgatgt gctaagtgac cccaagaaac ggggcctgta tgaccagtat ggggaggaag      360

gcctgaagac cggcggtggc acatcaggtg gctccagtgg ctcctttcac tacacctttc      420

atggggaccc ccatgccacc tttgcctcct tctttggtgg ctccaacccc ttcgatatct      480

tctttgccag cagccgctcc actcggccct tcagtggctt tgacccagat gacatggatg      540

tggatgaaga tgaggaccca tttggcgctt tcggccgttt tggcttcaat gggctgagta      600

ggggtccaag gcgag                                                       615


<210> 3358
<211> 580
<212> DNA
<213> Homo sapiens

<400> 3358
ttagtgcttt ttatcgtctt aaggaggtat ttggtggagg ctctttgaag ttgggttcag       60

gagtgtagaa ttggcaaagt tattgccagc ttcctgcatc aacaacagca acttgtgatt      120

ggcggtgacc ggatattcag ttgcacatcc ccacatcaat gcactgccaa tgatgaggaa      180

actgaggcct tggactagaa cagaggtctc ctgactcagt ccaggactct ttctattaca      240

tcatgcggcc tgatatttgt ctttatggaa ctcagcaaca tcacatacag gggttatatc      300

ctgtgttgtg acctcatggt ttaagtggga ataaagatga gtataagcag tgatgaggtc      360

aacttcttgg tatatagata cttgcaagag tcaggatttt ctcattcagc atttaccttt      420

ggtatagaaa gccatatcag tcagtccaat ataaatggtg ccctcgtccc acccgctgca      480

ttgatttcta tcatccagaa aggtctacag tatgtagaag cagaagttag tattaatgag      540

gatggtacct tgtttgatgg tcgaccaata gagtctctgt                            580


<210> 3359
<211> 1502
<212> DNA
<213> Homo sapiens

<400> 3359
agttggcaag atggcgccgg tgggggtgga gaagaagctg ctgctaggtc ccaacgggcc       60

cgcggtggcg gccgccggcg acctgaccag tgaggaggag gaaggccaga gcctatggtc      120

ctccattctg agcgaagtgt ccacccgcgc caggtccaag ctgccgtccg gcaagaacat      180

cctggtcttc ggtgaagatg gttctggtaa aacaaccctc atgactaaac tacaaggagc      240

tgagcatggc aaaaaaggaa gaggcctaga atatctctac ctcagtgtcc atgatgagga      300

ccgagatgtt gtgaaagatt ttcaagacta tatggaacct gaagaaggtt gtcaaggttc      360

cccacagaga agaggccctc tgacctcagg ctccgatgaa gaaaatgttg ccctgcctct      420

gggtgacaat gtgctgactc ataacctggg gatcccggtg ttggtggtgt gcacaaagtg      480

tgatgcggtg agtgtcctgg agaaggagca cgattacagg gatgagcatt tggactttat      540

ccagtcacac ctgcggaggt tctgccttca gtatggagct gccttgattt acacatcagt      600

gaaagaagag aaaaacctcg acttgttgta taagtatatt gttcataaaa catacggttt      660

ccacttcacc acacctgcct tagttgtgga aaaggatgcc gtttttatac ctgcaggctg      720

ggacaatgaa aagaaaatag ctattttaca tgaaaatttt acaaccgtga agccggaaga      780

tgcatatgaa gactttattg tgaaacctcc cgtgagaaag ctggtccacg acaaagagtt      840

ggcagcagaa gatgagcagg tgttcctaat gaagcaacag tcactccttg ccaagcaacc      900

agccactccc acgagagctt ctgaatctcc tgcaagagga ccctctggct ctccaaggac      960

ccagggtcgg ggagggccag ccagtgtgcc tagctcctcc ccaggcacgt cagtaaaaaa     1020

gccggaccca aacatcaaaa ataatgcagc aagtgaaggg gtgttggcca gcttcttcaa     1080

cagtctgttg agtaaaaaga caggctctcc tggaagtcct ggtgctggtg gggtgcagag     1140

cacagccaag aagtcaggac aaaagactgt gttgtcaaat gttcaggaag aactggatag     1200

aatgactcga aagccagact ctatggtaac aaactcttca acagaaaatg aagcctgaac     1260

ctccttaaaa agtgcatatg tcgaatgacc aaataactat gtatattgat ctgctaagac     1320

caggattttt ctgatatggc acatgctatc agttttttgg ggcaggggag atgaacttta     1380

aaaaaaaaaa aaaaacttca ttggcttgtc cgagtgtgaa atgcacattt aggaaggtta     1440

catgtcagac cctttgttaa ggataaccct tggactctgg ggcatgtggc tcttttgtgg     1500

ga                                                                    1502


<210> 3360
<211> 2672
<212> DNA
<213> Homo sapiens

<400> 3360
gaatctccgc tgtagcgtca cctggaaggc agatctaaca gagaacctgg actgtctcct       60

atcatgattc ccgggaaata tcgctctgtt tctggccggg ctgcgaacaa cgtgaactgc      120

gggcttcatc tggttattca aacatcatcg cttcctgaaa aaaacaaagt tgaattcaag      180

ctaaataaag acacatcgtc attccccggt agacttttac aacatgacct tgaaagaaac      240

tactcaagta ggcaagattt taccaagaat ataaagaatg taaaatgagg tccatcaccc      300

aaggagcttg tagatttatt tgggaagaca agggctacat atctggtgat catattaatt      360

tggtgagctc atcattgtca tcatttccta ttcttcaacg ttcttctgaa gagaaaattc      420

tttactcaga caggttgagc ctagaaagac aaaagctgac cgtatgtcct atcatcaatg      480

gggaagacca ccttcgtttg ttgaactttc aacacaattt tataactcgg atacaaaata      540

tttctaatct acagaagtta atatcgttgg atttatatga taaccagatt gaagaaatta      600

gtgggctttc gactctgaga tgtcttcgtg tccttctgtt ggggaaaaac agaatcaaga      660

aaatctcaaa tctggagaat ctaaaaagct tagatgtctt ggatcttcat ggaaatcaga      720

ttaccaaaat tgaaaatatt aatcatttgt gtgagttgag agttttaaat cttgccagga      780

actttttaag tcatgttgat aatcttaatg ggctggattc actaactgaa cttaacttgc      840

gacacaatca aatcactttc gtgagagatg tggataattt gccctgcctc caacatctct      900

ttctcagctt taacaatata tctagttttg acagtgtttc ctgccttgct gactcttctt      960

ccctctcgga catcaccttt gatggcaatc ccatagctca agagtcatgg tacaaacaca     1020

ctgtccttca gaatatgatg cagctgcgcc agctagatat gaagagaatc acggaagaag     1080

aaaggcgtat ggcatctgtt ttagccaaaa aagaggaaga gaagaagcgg gaaagtcata     1140

aacaatcttt gcttaaggag aagaaaaggt taacaattaa caacgtagct cgacagtggg     1200

acttgcaaca acaacgagta gccaatattg ctacaaatga agatagaaaa gattctgact     1260

ctcctcagga cccctgtcag attgatggaa gcaccctctc tgcattccca gaggaaacag     1320

ggcctctaga ctcaggactc aacaatgctt tacaaggttt atctgtcata gacacatacc     1380

ttgttgaagt ggacggggat acactttccc tatatggctc aggagcactg gaatctctgg     1440

ataggaattg gagtgttcaa acagcaggaa tgatcacaac agtctccttc actttcatag     1500

aatttgatga aatcgtccaa gtgcttccta aactgaagat taagtttcct aattctctgc     1560

accttaaatt caaggaaaca aatcttgtaa tgctgcagca atttaacgca ctagcccaac     1620

tccgtcgtat tgaccagttg acaattgatc ctcaaggaaa tccagttgtc aattttacac     1680

tctggaaata ctatgtactg tttaggctaa gccatttcag tatgcagaaa ataaatggaa     1740

cagaggtgac acagaatgat atgataatgg ctgaaaggct ctttggaatc ctagcacatg     1800

tagcatcttc tgagttaccc cagtatcgtc tgatttccat tctgggtgat gccaggaaaa     1860

agcaatttcg gtatctacta gaatccaaag gaaaaaaacc tggtattatc aacgaagaaa     1920

ataatgacag caaaagactt gtaggagaaa acacaaatcg tgctacatta aattatacta     1980

caagagactt ttataatgaa aagctagagg aaataaagga aaagaagaaa ttctgtaaaa     2040

catatataga agaccttgtg aaggaagcca cagaaatcaa catgaaaaat gaggctttgc     2100

agaagctttg gccacagatg ttcattgagc ttgttaggga tgcagtcata gaaattcgca     2160

ataaaaattc ctatatgaag ctctgcctac agcagataac agaccaaaaa taaaaatggc     2220

ctttagttac agttgatttt ggcagtttta ttttttgaag gttgaaaata tgcaggttat     2280

acatgttaaa acaacaacaa cactatccta taaactagaa agactagtat aaaagcatta     2340

ttgcccactg ttctcatagc taaaagttaa gaaggaagga aggaaagcag gagaaaggaa     2400

ggattaattg cctgtatgtg aggaccaaac aacctttggg aactaaacag ttttcagaga     2460

tggcgtggca ctgcatcctt ggttcttgct ttgattggtg ccctgctata gcccaaagca     2520

cgtagtattt gctgatgatt cagcatgagc tgcatctacc tacttttagc tgataatttt     2580

cagttatttc cctttttatt ttatgtcatg atttcaaagc caaaaatatg ttctttttat     2640

gagtgaagaa taaacttact aacaaattag tc                                   2672


<210> 3361
<211> 430
<212> DNA
<213> Homo sapiens

<400> 3361
cgccttggga ggtatgaggt agagaaacgc tgtgccgtgg agaaggaaga ctacgatctc       60

gccaaggaga agaagcagca gatggagcag tatcgtgccg aggtgtacga gcagctggag      120

ctgcacagcc tcctggatgc cgagctgcat tctgcagtag acccgttact ccctgccaca      180

gatcctcatc caaagatcaa tgcagagtcc ctgccctacg atgagcggcc tcttccagct      240

attcgtaagc attatgggga ggcagtggtg gagccggaaa tgagtaatgc agacatcagc      300

gatgctcgga ggggaggcat gttaggggag ccagagccct taaccgagaa ggccttgaga      360

gaagccagct ctgccatcga tgtgttggga gaaaccttgg ttgctgaggc ctattgtaag      420

acgtggtcct                                                             430


<210> 3362
<211> 4599
<212> DNA
<213> Homo sapiens

<400> 3362
actttgccag agcggccggg tccccattcc cattccttca aatccccttt ttcccggcag       60

ccgacctgta gacccaaggg agacaggttg aagctagaaa gagtcggggc agcagctctg      120

gtaggggagg gagcatccaa aacctctggc ttctgagcgc ctctcctgcc gcccatccac      180

aaagcccccc acagcctggc ggctgccctc gaccccgcaa aacaaaggac ttcagaggct      240

ggacctacag acccagatga gaaggcaaaa gcgtagggag gagcggcagg agatgggaag      300

ggcgggcccc gctcggagca gctgccgctt cctcccaaag tcccacgagg ggcctgagtc      360

acgggccacc gccctgggtc ggcgagctgg gggaagggat ctggacacct ggcgtgtccg      420

ggcgggaagc tggtgagggc ccctggggac agagcggagg accagtggtt ggggcgagaa      480

gagggcagtc ccgcagcgag tcccacgcgg ggtgggaggg atctaggccc cgccctctcc      540

tcggctccgc cctgcgcccc cttccctctc ctcattgtcc ttagacaaag cggtcgccgc      600

ccccgcccgg ccccctggtc tctgtctccg tccctcctcc tttgctgcct ctttccctcc      660

tcctctccct ccctcctccc ctccctccag tctccggatc tccctcggtc cctctctcct      720

cctcttcctc tctctggacg cccggctcct ccgcaccccc tcccccgggg gtcccgcggc      780

ctgtgagttg actgaggggc tcagacttgg ggagtgggtg tctcctcgcc cctgtccttg      840

ctcccgtccc tggcccggac cttggctgtc tcctctttgt gccgagattg tcagtctgtg      900

cggctacagc ggggtggaga cggccggctc tgtcacggct tcatgagagc ggggacgggg      960

cgcaggactt gcaggcgccg gggagaagag acatggagcc ggcccttggc actctggggt     1020

cgcgtggggc agtcggtggg ggaggcaggc ggtggtgaca ggacagggtg ggggtggacg     1080

ccagggttct gggaacgcgc tggcagccct gacgcccggg ttccgaaagt ctcgggggtg     1140

gctatttccc ccgacccgcc tcgggggcgg agtgcggggc agaggggtgg gggctgggga     1200

gaggcgtggc ccgagcggtg ctggaagcgg agccgggacc tttggggccc gcgctgagac     1260

gcgcccggct gctgccgccg ccctcctttc ccctcttccc tggtttccct tctcctctag     1320

acctgttcgc tctccgcccc tccttgcctc cccaacaccc cctcaggtcc cgttgcctcc     1380

tggtcctttc agggattcct ggtccttcct tcccacacta gcctccctgg ggtatcgctg     1440

aggcagcctg gcctgcaccc aggttcccct cacccctgcc acatttctct cttctccctc     1500

acgccaactt tccttttcgc ccttctctct ctttctcaca tcctagagac ggtctttaat     1560

acgcattaac cctgtgctgc cacatctggc tcctgccctc attgcctcca atccggactc     1620

ttcctctcac atcaccccca ccacccccaa cttgggctca caacttctct tcactttttc     1680

catttcccca gttctctgcc ttccgtcttt ccctctgtcc tcatccttag cccctctgcc     1740

ctgctttgtg tcccacctct ccccctccac ttcctctcct cccaccctca gtctcacccc     1800

cgggctgtct cactctctgg agcctctcct tcctgttctc tgtccccagt gctccctacc     1860

ctcacctcaa gacgaccatg gccaccatcc cagactggaa gctacagctg ctagcccggc     1920

gccggcagga ggaggcgtcc gttcgaggcc gagagaaagc agaacgggag cgcctgtccc     1980

agatgccagc ctggaaacga gggctcctgg agcgccgccg ggccaagctt gggctgtccc     2040

ctggggagcc tagccctgtg ctagggactg tagaggctgg acctccagac ccggatgagt     2100

ctgcggtcct tctggaggcc atcgggccag tgcaccagaa ccgattcatc cggcaggagc     2160

ggcagcagca gcagcagcaa caacaacgga gtgaagagct gctagcagag agaaagcctg     2220

ggcctctgga ggcccgggag cggagaccca gccctgggga gatgcgggat cagagcccca     2280

agggaagaga gtcaagagaa gagagactaa gtccgaggga gaccagagag aggaggctgg     2340

ggataggggg agcccaagag ttgagcctga ggcctctgga ggctcgggac tggaggcaaa     2400

gcccaggaga ggtgggagac aggagctccc gactgtcaga ggcatggaaa tggaggctga     2460

gtcctggaga aactccagag cggagtctga gactagcaga gtctcgagag caaagcccca     2520

ggagaaaaga ggtggaaagt agactgagcc caggggaatc tgcctaccag aagttgggcc     2580

tgacagaggc ccataaatgg agacctgact ccagagagtc tcaggaacag agtttggtac     2640

aactggaggc aacagagtgg aggctgaggt caggagaaga aagacaagac tactcggaag     2700

aatgtgggag aaaagaagag tggccagttc caggggtagc tccaaaagag actgcagagc     2760

tgtccgagac cctgacaagg gaggcccaag gcaacagttc cgcaggagtg gaggcagcag     2820

agcagaggcc tgtggaagat ggcgagaggg gcatgaagcc aacagaaggg tggaaatgga     2880

ccctgaactc cgggaaggct cgagaatgga cacccaggga catagaggct caaactcaga     2940

aaccagaacc tccagagtca gcagagaagc ttctggaatc tcccggtgtg gaggctggag     3000

aaggggaggc tgagaaggag gaggcggggg ctcagggcag gcctctgaga gccctgcaga     3060

actgctgctc tgtgccctcc cccctcccac cagaggacgc tgggactgga ggcctgagac     3120

agcaggaaga ggaagcagtg gagctccagc ccccaccacc agcccctctg tctcccccac     3180

ccccagcccc aactgccccc caacctcctg gggatcccct catgagccgc ctgttctatg     3240

gggtgaaggc agggccaggg gtgggggccc cccgccgcag tggacacacc ttcaccgtca     3300

acccccggcg gtctgtgccc cctgcgaccc cagccacccc aacctctcca gccacagttg     3360

atgctgcagt cccgggggct gggaagaagc ggtacccaac tgccgaggag atcttggttc     3420

tggggggcta cctccgtctc agccgcagct gccttgccaa ggggtccccc gaaagacacc     3480

acaaacagct taagatctcc ttcagcgaga cagccctgga gaccacgtac caatacccct     3540

ccgagagttc ggtactggag gagctgggcc cggagcctga ggtccccagt gcccccaacc     3600

ctccagcagc ccaacccgac gacgaagagg atgaggaaga gctgctgctg ctgcagccag     3660

agctccaggg cgggctgcgc accaaggccc tgattgtgga tgagtcctgc cggcggtgac     3720

catcttccaa catagggata tacctccctc cttcttataa ctgaagatcc tggagcccgg     3780

aagattcagg gcagacagac cctgataatg agcctggcag ggaagggcaa ccaacatctt     3840

gtaacttgct ttccccaccc tgtttctggg ggcagagcca attgcccaat ttctacccta     3900

atccaaagtc cctggtgtgg gtggggttaa acgtgctggt gcatcctagg tcatccaaga     3960

gtgagcgcca agtcctgaga aggggcacag aactccctgg agggtggaga tggagcacct     4020

gccccccatg gcagggtaca ctctccccac agccttcctc cccaccatcc cgtggggact     4080

ctcgggattt aagcactcgt ctctctggga ggcccagacc ccactccatt tataggcaca     4140

tctccttcat ttcctaggtc actgcccctt tgtttacagc tcctgcctcc tcccttgacc     4200

acagcctggt ttacaaattc catcagctcc cagccccacc tgccaaagtc ccaggtttac     4260

aagccacgct tacttgctgt gtctgcgtgg aattctctcc tctgtcccct ccagtctcct     4320

cattggagtg acctgaaggt gtggcttcct ccactttttc tcagtattac tttgccttag     4380

ttttccccaa gagggaaggc tggaactctt aactctgtac cccttgatag ttatttaatt     4440

ctgtttctcc tagtggttca caattgaact gaattgagat ggtgtcgggt ggctaaggag     4500

acacctcacc tctccttccc cattgtgccg cctttatcaa ttgcctgttt tgttttgttt     4560

gttttttaac tttccataat aaaatggagt tctcttcaa                            4599


<210> 3363
<211> 850
<212> DNA
<213> Homo sapiens

<400> 3363
agaagctggg cagcctctgc cgggttccgg gaaaaggagc tcctgctgcc actgctcttc       60

cggagcctgc agcatggggc ccctgccgcg caccgtggag ctcttctatg acgtgctgtc      120

cccctactcc tggctgggct tcgagatcct gtgccggtat cagaatatct ggaacatcaa      180

cctgcagttg cggcccagcc tcataacagg gatcatgaaa gacagtggaa gtttgtctgc      240

catgcgtttc ctcaccgccg tgaacttgga gcatccagag atgctggaga aagcgtcccg      300

ggagctgtgg atgcgcgtct ggtcaaggaa tgaagacatc accgagccgc agagcatcct      360

ggcggctgca gagaaggctg gtatgtctgc agaacaagcc cagggacttc tggaaaagat      420

cgcaacgcca aaggtgaaga accagctcaa ggagaccact gaggcagcct gcagatacgg      480

agcctttggg ctgcccatca ccgtggccca tgtggatggc caaacccaca tgttatttgg      540

ctctgaccgg atggagctgc tggcgcacct gctgggagag aagtggatgg gccctatacc      600

tccagccgtg aatgccagac tttaagattg cccggaggaa gcaaactctt cgtataaaaa      660

aagcaggcca tctgcttaac ccttggctcc accataaggc actgggactc ggatttctct      720

atctgataga ggtattttct gtggccctgg gagctgtctg tctttcccct acccccaagg      780

atgccaggaa gacgtccacc attagccatg tggcaacctt tacttctatg cctcacaagt      840

gcctttcaga                                                             850


<210> 3364
<211> 1210
<212> DNA
<213> Homo sapiens

<400> 3364
gagggcacca gtggtaagac agcgctgcac ctggctgtgg aaacccaaga gcggggcctg       60

gtacagttcc tgctccaggc tggtgcccag gtagatgccc gcatgctgaa cgggtgcaca      120

cccctgcacc tggcagctgg ccggggtctc atgggcatct catccactct gtgcaaggcg      180

ggtgctgact ccctgctgcg gaatgtggag gatgagacgc cccaggacct gactgaggaa      240

tcccttgtcc ttttgccctt tgatgacctg aagatctcag ggaaactgct gctgtgtacc      300

gactgaagcc agtacagtcc tgagccgagg aggagggact gcaagtggaa gagagccagt      360

ctggaaggaa gagctttcca ggtggacagg gcttcttgga agacccccaa agccccaggt      420

atcctgggtg aagcctgttt gcctctcttg aaaatggcag gtgctcttgt tttacccatg      480

ttgggtcagc ctgaaactgc caaccagtag gaagcatgga ctctcctgag tgagaagaga      540

ctgaaatagg agcaagcaga accctgagag gtgtcccatc ttattgctgt tgaggaccct      600

gaaacaccgt tgtttaaaga cttcacacag aaggctctga actgagccac tggggaaggg      660

aagtttcagt aacatgacac taaaatggca gagacgttaa aaaaagtttt tcccttctag      720

agctgttttg cgcgcatgca tgtctgtgtg cattggggct ttttagacag gcctgccctg      780

tgactttgtg gtagaggcag agagaaggaa attgtcccct gagcacggta gggccttgct      840

gggtggggtc agaggccagt agttccaggc ctttctctgt gtccagcaca gacccttgtc      900

cttgctgtgg aaatgatgag ggatggaggg acaagaggaa gaatgagagg acacacgccc      960

tggagccctc accactgccc tgggggttgc catctggagg agcctgggga taagggtaac     1020

ccagggaggc tgggcacgag ggagctgact ccacgttttt ccccccgttc ctcaccttcg     1080

agggccctgc taggtcaccc ctatgctggc atgaagagca tggggcaata aaccagcaca     1140

gtctctgacc acttggagcg tctcatccag tgagagagac agccgttaaa agcataaaca     1200

tccaaataaa                                                            1210


<210> 3365
<211> 15137
<212> DNA
<213> Homo sapiens

<400> 3365
cctctgcgga gccgggctcg ggtcgccgga gccgcgcccc accccgccag ctccagagcc       60

acgactaatg gctgaaggat aaatcaacat ggcaactatg attccaccag tgaagctgaa      120

atggcttgaa cacttgaaca gctcctggat tacagaggac agtgaatcta ttgctacaag      180

agagggagtt gctgttctgt attctaaact ggttagcaat aaggaagtag tacctttgcc      240

ccaacaagtt ttatgcctca aaggaccaca gttgccagac tttgaacgtg agtctctttc      300

aagtgatgag caggaccact atttggatgc ccttcttagc agccagctag cattggcaaa      360

gatggtatgt tcagattccc catttgccgg ggcacttaga aaacgactgc ttgtactcca      420

gcgtgtcttt tatgcacttt ctaataaata ccatgacaaa ggcaaggtga agcagcagca      480

gcattctccg gagagcagtt ctggttcagc agatgtccat tctgttagtg aacgcccccg      540

gtcaagcact gatgcactta tagaaatggg tgttcgaact ggtctaagtt tattatttgc      600

gcttctaaga caaagttgga tgatgcctgt gtcaggacct ggtctcagtc tttgcaacga      660

tgtcattcat actgcaattg aagttgtgag ctctttgcca ccattatcat tagcaaatga      720

aagcaagatt cctcctatgg gcttggactg cttatcgcaa gtaacaacat ttcttaaagg      780

agtcactatt cctaattctg gggcagacac tttaggtcgt agattagctt ctgagttgct      840

gcttggtttg gcagctcaac gaggctcatt gcgatatctt cttgaatgga tagaaatggc      900

tttgggggct tcggcagttg tacacaccat ggagaaaggc aaactactct caagccagga      960

aggaatgatc agctttgact gctttatgac catattaatg cagatgaggc gttctttggg     1020

ttcatctgct gatcggagtc agtggagaga accaaccaga acatcggatg gcttgtgctc     1080

cctttacgag gcagcattat gtctctttga agaggtttgc agaatggctt ctgattattc     1140

gagaacatgt gctagcccag atagcattca gactggtgat gctcccattg tctccgaaac     1200

ctgtgaggtt tatgtttggg ggagcaatag cagccatcag ttggtagaag gtacacagga     1260

gaaaatactg caacccaaac tggctcctag tttctctgat gcacagacca ttgaagctgg     1320

acagtactgc acttttgtca tttctacgga tggctctgtt agagcttgcg ggaaaggcag     1380

ctatgggaga ctgggccttg gagactccaa taatcagtca actttaaaaa agttaacatt     1440

cgagcctcac agatccatta aaaaggtttc atcttctaaa ggatctgatg gtcacacttt     1500

agcctttacg acagaaggag aagtcttcag ttggggagat ggtgattatg ggaaactggg     1560

gcatggaaat agttcaacac agaaatatcc caagcttatt cagggacctc tacaaggaaa     1620

ggtagttgtt tgtgtgtcag ctggatacag acatagtgct gctgtcacag aggatgggga     1680

attatacaca tggggtgaag gagactttgg aagattaggt catggtgaca gcaatagtcg     1740

taacattcca acattagtaa aagacatcag caatgtagga gaggtttctt gtggcagttc     1800

acatactatt gctctgtcta aagatgggag aactgtatgg tcttttggag gaggagacaa     1860

tggtaaactt ggtcatggtg ataccaacag agtgtataaa cctaaagtta ttgaagcttt     1920

acaaggaatg ttcattcgca aagtttgtgc tgggagccag tcttcacttg ctttgacatc     1980

aacagggcag gtctatgctt ggggctgtgg agcttgtcta ggttgtggtt cttcagaagc     2040

tactgctttg agacccaagc ttattgaaga actggctgcc acaagaatag ttgatgtttc     2100

tattggagac agtcattgtt tggctctttc tcatgataat gaagtttatg cctggggcaa     2160

taactcaatg gggcaatgtg gtcagggaaa ttccacaggt cctattacta aaccaaagaa     2220

agtgagtggc ttagatggca tagctattca gcagatttcg gctggaacat cacatagtct     2280

ggcatggact gctcttccta gggacagaca agttgttgca tggcaccgac cttattgtgt     2340

agatcttgaa gagagtacct tctcacacct gcgttctttt cttgagagat actgtgataa     2400

aataaacagt gagattcccc cactcccttt cccttcatca agagaacacc acagttttct     2460

caagctgtgc ctgaagctac tttcaaatca ccttgctctt gcacttgcgg gaggggtagc     2520

taccagcatt ctcgggaggc aggcaggtcc acttcgaaat ttgctcttca gactgatgga     2580

ctcaactgtc ccagatgaaa tccaagaggt ggtaattgaa actttatcag tgggagcaac     2640

catgctgtta cctccattac gagaacggat ggaattactt cattctcttt tacctcaagg     2700

acctgataga tgggaaagct tatctaaagg acagagaatg caactggata tcatcctgac     2760

aagtttgcaa gatcataccc acgtagcctc cctacttggc tatagttcac cctctgatgc     2820

tgctgaccta tcttctgtgt gtactggcta cggaaatctg tcagatcaac cttacggcac     2880

tcagagctgc catccagata cccacctggc tgaaattttg atgaagaccc tcttaagaaa     2940

tttaggattt tatacagatc aagcatttgg agagctagaa aagaatagtg ataaatttct     3000

acttggaaca tcatcatcag aaaacagtca gcctgctcat cttcatgaac tgctatgttc     3060

actacagaaa cagctgctgg cattttgcca tatcaataac attagtgaga actcaagcag     3120

tgtggcattg cttcataaac atcttcagct tttgttgcct catgccacag atatttattc     3180

acgttctgca aatttgctca aagaaagtcc ttggaatggc agtgttggag aaaaattaag     3240

agatgtgata tacgtctcag ctgctggcag tatgctctgc cagattgtta actccctgct     3300

gttactccct gtgtcagtgg ctcggccttt attgagttac ctcctcgact tgttgccacc     3360

tcttgattgc cttaatagac tcctgccagc tgctgatctt ttagaagacc aggagttaca     3420

gtggcctctt catggagggc cagaactaat tgatcctgct ggtctgccat tacctcagcc     3480

agctcagtcc tgggtatggc ttgtggatct agaaagaaca attgctctcc ttattgggcg     3540

gtgtcttggt ggcatgcttc agggctcccc tgtgtctcca gaggaacagg acactgcata     3600

ttggatgaaa acgccactgt tcagtgacgg tgtagaaatg gacactcctc aattggataa     3660

atgtatgagt tgcctgttag aagtagcact ttctggaaat gaagaacaga agccttttga     3720

ttataaattg cggcctgaaa ttgctgtcta tgtagacttg gcattgggtt gttctaaaga     3780

gcctgcccga agcctttgga tcagcatgca ggactatgct gttagtaaag attgggacag     3840

tgcaacttta agtaatgagt cactcttgga cactgtgtct agatttgttc ttgcagctct     3900

tctgaaacac acaaatttac ttagtcaagc atgtggagaa agccgatatc aacctggtaa     3960

acacttatca gaagtgtacc gttgtgtata caaagttcga agtcgtttac ttgcttgcaa     4020

gaaccttgaa cttattcaaa caaggtcatc atcacgggac agatggatat cagaaaacca     4080

ggactctgca gatgttgatc ctcaggagca ttcatttact cgaactattg atgaagaagc     4140

tgaaatggaa gaacaggctg agagagaccg ggaagagggg catccggagc cagaggatga     4200

agaggaggaa cgggaacatg aagtgatgac agctggcaaa atctttcagt gtttcctctc     4260

agcccgtgaa gtagctcgta gccgagaccg agatagaatg aacagtgggg cagggtctgg     4320

ggctcgagct gatgatccac ctcctcagtc tcagcaagag cgaagggtca gcacagacct     4380

tcctgagggt caggatgtgt acactgctgc atgcaactcc gtgatccatc ggtgtgccct     4440

gttaatatta ggagtaagtc ctgtgataga tgagcttcag aagcgaagag aagaaggaca     4500

gttgcagcaa ccttcaacaa gtgcctctga agggggtgga cttatgacca ggagtgaaag     4560

tcttactgca gagagccggc tagtccacac aagcccaaat tatagactga tcaaatcgag     4620

gagtgaatct gatttgtctc agcctgaatc agatgaagag ggttacgcac tgagtggcag     4680

acgaaatgtt gatttggatt tggcagcatc tcacagaaag agaggtccta tgcacagtca     4740

attggaatcc ctgagtgact cttgggctcg cctgaaacat agcagagact ggttatgcaa     4800

ctcctcctat tcctttgagt cagattttga tcttaccaag tctttgggag ttcacacttt     4860

gattgaaaat gttgtaagct ttgtgagtgg agatgtgggg aatgccccag gttttaaaga     4920

gccagaggaa agtatgtcta caagtcccca ggcctccatc attgcaatgg aacagcagca     4980

gttaagggca gaacttcgtt tagaggcact tcatcagatc ctcgttctat tgtctgggat     5040

ggaagaaaaa ggtagcatct cactggcagg aagcagattg agttcaggct tccagtcctc     5100

cacactactc acgtctgtga ggctgcagtt cctagcaggg tgttttggtt taggcactgt     5160

tggacacaca ggaggcaagg gagagagtgg ccgattgcat cactatcagg atgggatcag     5220

agcagctaag agaaatattc agattgaaat ccaggtagct gtgcataaaa tttatcaaca     5280

gttgtctgct accctggaaa gagccctgca agcaaacaag catcacattg aagcccagca     5340

acgtctgctt ctggttacag tttttgccct aagtgttcat tatcaaccag tagatgtttc     5400

tttggcaatt tccactggtc tgctaaacgt attgtcacag ttgtgtggta cagacaccat     5460

gctaggacag cccctgcagt tgttgccaaa gacgggtgtt tcccagctta gcacagcttt     5520

gaaagtggcc agtacaaggt tgctccagat tctagccatc actactggga cctatgctga     5580

taaactgagt cccaaagtag ttcaatcctt gttggatcta ctctgtagtc agttgaagaa     5640

tttattgtcc caaactggtg tactacatat ggcctctttc ggagaagggg agcaagaaga     5700

cggtgaagaa gaagaaaaaa aagttgactc cagtggagaa actgagaaga aagatttcag     5760

agctgctctt aggaaacaac atgcagccga actccatcta ggggattttt tagtttttct     5820

tcgcagagtt gtatcttcaa aagcaattca atcaaaaatg gcttccccaa agtggaccga     5880

agtgcttcta aatatagcat ctcagaaatg ttcttcaggt atccctctgg ttggtaactt     5940

aagaacaagg ctccttgcac ttcatgtcct tgaagctgtg ctgccagctt gtgaatctgg     6000

tgtagaagat gatcaaatgg cccagattgt tgagcgctta ttttcccttc tctctgattg     6060

tatgtgggag acacccattg ctcaggccaa acatgctatt cagataaagg aaaaagaaca     6120

agaaataaaa ctacagaagc agggcgagtt ggaagaagaa gatgagaatc ttcctatcca     6180

agaagtatcc tttgacccgg agaaagctca gtgttgccta gtggagaatg gacagatttt     6240

aactcacggc agtggaggga aaggatatgg attggcatct acaggagtaa cttctgggtg     6300

ctatcagtgg aagttttata ttgtgaagga aaacagaggt aatgaaggca cgtgtgttgg     6360

agtttctcgc tggccagtac atgactttaa tcaccgcact acctcggata tgtggctcta     6420

tagggcctac agtggtaacc tctatcacaa tggagaacag actctcacat tgtccagctt     6480

tactcaagga gatttcatta cctgtgtgtt agacatggaa gccaggacca tttcttttgg     6540

gaaaaatgga gaggaaccca aattagcttt tgaagatgtg gatgcagcag agttgtaccc     6600

atgtgtgatg ttctatagta gcaatccagg ggaaaaggtg aaaatttgtg atatgcagat     6660

gcgtggcaca ccccgagact tacttccagg agaccctatt tgtagtccag tagcagcagt     6720

gctggctgag gccactattc agctcatccg tatccttcac cgaacagacc gttggactta     6780

ctgcattaac aaaaaaatga tggaaaggct tcacaaaatt aagatatgta ttaaagagtc     6840

aggtcagaag ctaaagaaaa gccgctcggt tcagagccga gaggaaaatg aaatgagaga     6900

ggagaaggag agcaaagagg aagagaaagg taaacatact aggcatggcc tcgctgacct     6960

ctcagagctg cagctgagga ctctttgcat agaggtgtgg cccgtgctgg ctgtgatagg     7020

aggagttgat gctggtctta gagttggagg tcggtgtgtt cacaagcaaa ctgggcgcca     7080

tgccacgctg ctgggagtgg tcaaagaggg cagcacgtct gccaaggtcc aatgggatga     7140

agcagaaatt actatcagct tcccaacttt ttggtcgcct agtgatactc cattgtataa     7200

tctggaaccc tgtgaaccat tgccgtttga tgtggcgcga ttccgaggcc tgacggcttc     7260

tgtgctgctg gacctaacat atctcactgg cgttcatgaa gacatgggca aacagagcac     7320

caaacgacat gaaaagaaac accgacatga atccgaggag aaaggggatg ttgagcagaa     7380

acctgagagt gaatccgctt tagatatgcg aacaggccta acatctgatg acgtcaaaag     7440

tcagagtacc acaagctcca aatcagaaaa tgaaatcgct tcattttctt tagatccaac     7500

actgccaagt gtggaatccc aacatcaaat aacagaaggg aaaagaaaaa atcatgaaca     7560

catgtccaaa aaccatgatg tagcccagtc agaaatcaga gcagtccagc tgtcctatct     7620

ttacctcggt gctatgaagt cacttagtgc ccttcttggc tgtagtaaat atgctgagct     7680

gttgctgata ccaaaagttc tggctgaaaa tggccacaac tcagactgtg caagttctcc     7740

agttgttcat gaagacgtgg agatgcgagc agccctgcag ttcttgatgc gacacatggt     7800

gaagcgagca gtcatgcggt cacccataaa gagagcattg ggattagctg atctggaacg     7860

agcgcaagcc atgatctata aattagtggt tcatgggctt ttggaagacc agtttggggg     7920

caaaattaag caagagattg atcaacaagc tgaagaaagt gaccctgccc agcaggcaca     7980

gacaccagtt actactagcc catcagcctc aagcacgacc tcctttatga gcagctctct     8040

ggaggacacc acaactgcca ccactccagt cactgacaca gaaacagtgc ctgcatccga     8100

gtccccggga gtgatgcctc ttagtcttct caggcaaatg ttctctagtt acccaactac     8160

cactgtactt cccacacgtc gggcacagac tcctccaata tcttcgttac caacctctcc     8220

ttctgatgaa gtaggaagga ggcaaagttt aacttctcct gattcccagt cagcaaggcc     8280

agctaaccgc acagccttgt cagacccaag cagtagactt tcaacttctc ctcctcctcc     8340

agcaattgca gttcccttgc tggaaatggg gttctctctt cggcagattg ccaaagccat     8400

ggaagctaca ggtgctaggg gagaggctga tgcccagaat atcactgtcc ttgccatgtg     8460

gatgatagag caccctgggc atgaggatga agaggagccc cagtcgggca gcacagcaga     8520

ctctaggcct ggagcagccg ttctaggcag tggcgggaag tcaaatgatc cctgttattt     8580

gcagtcacct ggagacatac catcagctga tgctgctgaa atggaggaag gttttagtga     8640

aagccctgat aatttggatc atacagagaa tgcagcttct ggaagtggac catcagctag     8700

aggtcgctca gcggtaacaa gaagacacaa gtttgactta gctgctcgca cactgctagc     8760

aagagcagcg ggattatacc gctctgtgca ggcccacagg aatcaaagtc ggagagaagg     8820

aatatctttg cagcaagacc caggggcgtt gtatgacttt aatttagatg aggaattgga     8880

aattgatctt gatgatgagg cgatggaagc tatgtttgga caagacctga ccagtgacaa     8940

tgatattctg ggaatgtgga tcccagaggt actggattgg cctacctggc atgtttgtga     9000

gtctgaagac agggaagaag tggtggtgtg tgaactgtgt gaatgcagcg tcgtcagctt     9060

caatcagcac atgaagagaa accatccagg ctgtgggcgc agtgcaaacc gccagggcta     9120

tcgcagcaat ggttcctatg tggatggctg gtttggcggt gaatgtggga gtggaaatcc     9180

gtactacctg ttatgtggca cctgcaggga gaagtactta gccatgaaga ccaaatctaa     9240

gtcaacaagt tctgaaaggt acaagggaca agctccagat ctaattggca agcaagacag     9300

tgtgtatgaa gaagactggg acatgttgga tgttgatgaa gatgaaaagc taactggtga     9360

agaagaattt gaattacttg ctggaccgct tggtttaaat gaccggcgca ttgtaccaga     9420

accagttcag ttccctgaca gcgatccact gggagcatca gtagcaatgg tcacagccac     9480

caacagtatg gaagagactc tgatgcaaat aggttgccat ggctccgtag aaaagagctc     9540

ctctgggaga ataacgttag gagagcaggc agctgcccta gcaaaccctc atgaccgtgt     9600

ggtggcttta aggagagtga ctgctgctgc tcaggttctt ctggccagaa ccatggtcat     9660

gagagcgctg tctcttctct cagtcagtgg ttccagttgt agcctggctg ctggtcttga     9720

gtctctgggg ctaacagata tccgaacgct agttcgatta atgtgcttgg cagcagcagg     9780

gagagctggc ctctccacca gcccttctgc catggctagc acctcagaac gatcacgagg     9840

tgggcatagc aaggctaaca agcctatctc ttgcctggcc tatttgagca cagcagtggg     9900

atgtctggca tcaaatgctc ctagtgctgc caaactgctt gtacagttgt gtacacagaa     9960

cttgatttct gctgcaacag gtgtaaatct aaccacagtt gatgactcaa ttcagcgaaa    10020

gtttctaccc agctttctcc gaggaattgc tgaagagaac aagcttgtga cctccccaaa    10080

ctttgttgta acacaggccc ttgtggcatt gctagcagac aaaggggcca aactaagacc    10140

taactatgat aagtcagaag ttgaaaagaa aggccctctg gagttggcta atgccctggc    10200

agcctgctgc ctctcctcca ggctgtcctc acagcatcgg caatgggcag ctcagcaact    10260

cgtgcgcact cttgctgcac acgaccgtga caaccaaact actctgcaga cacttgctga    10320

tatgggagga gatcttagaa aatgctcctt tatcaaattg gaggctcatc agaacagagt    10380

aatgacatgt gtttggtgta ataaaaaagg tcttttggct acaagtggca atgatggcac    10440

catccgcgta tggaatgtta ccaagaagca atattcactg caacagacct gtgtgttcaa    10500

cagattggaa ggggatgctg aggaaagcct gggatcaccc agtgatccaa gtttctcacc    10560

agtttcctgg agtatcagtg gcaaatatct agcaggcgct ttggaaaaga tggtgaatat    10620

ctggcaagtt aatggaggaa aaggattagt agatattcag cctcattggg tatctgccct    10680

ggcttggcca gaagagggtc cggctacagc ctggtcagga gagtctccag aattgttgtt    10740

ggtgggacgg atggatggat ctctgggact gattgaagtt gttgatgtgt ccaccatgca    10800

ccgtcgagaa ttggagcatt gctatcgaaa ggatgtgtct gttacttgca ttgcatggtt    10860

cagtgaagac agaccatttg cagtgggata ttttgatgga aaactgttac tgggaacaaa    10920

ggaaccactt gagaaaggag gcattgttct aattgatgca cataaggata ctcttattag    10980

catgaagtgg gaccctacag gtcatattct tatgacatgt gccaaagaag acagtgtgaa    11040

actctggggc tctatttcgg gatgctggtg ctgtctacat tcactctgcc atccatctat    11100

tgtaaatggc attgcttggt gccgccttcc agggaaagga tccaagttgc agttactgat    11160

ggctactggc tgtcagagtg gcttagtatg tgtttggcgc attcctcaag atactacaca    11220

gaccaatgtg actagtgcag aaggatggtg ggagcaggaa tcaaattgcc aggatggata    11280

taggaaatca tcaggagcca agtgtgttta tcagctgcgg ggacacatca ctcctgttcg    11340

gactgttgcc tttagttctg atgggttggc cctggtgtct ggtggactag gtgggctcat    11400

gaacatttgg tctttaaggg atggctctgt cttgcaaact gttgtgatag gctctggagc    11460

tattcagacc acagtatgga ttccagaagt tggagtagct gcttgctcaa atagatcaaa    11520

ggatgttttg gtcgtgaatt gtacagcaga atgggcagct gccaatcatg ttttggcaac    11580

ctgtaggaca gcattgaaac agcagggtgt tctgggattg aacatggctc cctgcatgag    11640

agcatttttg gagcggctcc ccatgatgct tcaggagcag tatgcctatg aaaagcctca    11700

tgtggtttgt ggtgaccaac ttgttcatag cccctatatg caatgcttgg cttcccttgc    11760

tgtgggactt catctggatc agctgttgtg taaccctcca gtgccaccac accaccagaa    11820

ctgtctccct gaccctgcat cctggaatcc aaatgaatgg gcctggttag aatgtttctc    11880

aaccactata aaagctgccg aagccctgac caatggagcc cagtttccag aatcttttac    11940

cgttccagat ctagaacctg ttccagagga tgaacttgta tttctaatgg ataacagtaa    12000

atggattaac ggcatggatg aacaaattat gtcttgggca acttccagac ctgaggactg    12060

gcacctggga ggtaaatgtg atgtctactt atggggtgct ggtaggcatg gacagctggc    12120

agaagctgga agaaatgtaa tggtacctgc agcagctccc tcattctcac aggcccaaca    12180

ggtcatttgt ggtcagaatt gtacctttgt catccaggcc aatggcacag tgttggcttg    12240

tggggaagga agttatggca gattaggaca aggaaattca gatgaccttc atgtgctgac    12300

agttatttca gccttacaag gctttgtggt gacccagctg gtgacttcct gtggttctga    12360

tgggcactct atggccctaa ctgaaagtgg tgaggtcttt agctggggag atggtgacta    12420

tggtaaactt ggccatggga acagcgacag gcagcggcgg cccaggcaga tcgaggcctt    12480

acaaggagaa gaagtggtgc agatgtcttg tggcttcaag cactcagcag tggtcacttc    12540

agatggcaaa ctgttcacct ttgggaatgg tgactatggt cgtctgggtc ttggaaatac    12600

ctctaacaaa aaacttccag agagagtgac tgcactggag ggatatcaga ttggacaggt    12660

ggcctgtgga ttaaaccaca ctttggcagt gtcagcagat ggttccatgg tgtgggcttt    12720

tggagatgga gactatggaa aactaggctt aggaaattcc actgcaaaat cttcacctca    12780

gaaaattgac gtcctttgtg gaattggaat aaaaaaggtt gcttgtggaa ctcagttttc    12840

tgttgctttg accaaagatg gtcatgtgta tacctttggt caagatcgcc tgataggctt    12900

gccagagggg cgtgctcgca atcacaatcg accgcaacaa atccctgtcc tggctggagt    12960

aatcatagaa gatgtggcag ttggagctga acacacactt gctttggcat caaatggaga    13020

tgtgtatgcc tgggggagca attcagaagg gcagctcggc ttaggccata ccaaccatgt    13080

tcgagaacca accctggtaa caggtctgca agggaaaaat gttcggcaga tctcggctgg    13140

ccgctgccac agtgctgcat ggacagcacc acctgtccca ccaagagcac caggtgtgtc    13200

agtacctctg cagctgggcc tgcctgacac agtgcccccc cagtatgggg cgctgagaga    13260

agtcagcatt cacacggtgc gggccaggct ccggctgctc taccacttct ctgacctcat    13320

gtactcatcc tggagactgc tgaaccttag ccccaacaac cagaacagca catcccatta    13380

taatgctgga acttggggca ttgtacaggg acaacttcgg cctttgttag ccccaagagt    13440

ctacactctg ccaatggtgc gctccatagg aaaaaccatg gttcaaggca aaaactatgg    13500

acctcagata actgtaaaga ggatatcaac cagaggacgg aagtgtaagc ctatttttgt    13560

ccaaatagcg agacaagtag ttaagctgaa tgcttcagac ctccgcctgc cttcccgagc    13620

gtggaaggtt aagctggttg gagaaggggc tgatgatgct ggaggagtgt ttgatgacac    13680

catcacagag atgtgccagg aacttgaaac tggtattgtt gaccttctta taccctctcc    13740

caatgccacc gcagaagtgg gttacaatag ggacaggttc ctttttaacc cttctgcctg    13800

cctcgatgaa cacttaatgc agtttaagtt tttaggaatt ttaatggggg ttgccattcg    13860

cacaaagaag cctctggacc tccacttggc ccctctggtg tggaagcagc tgtgctgtgt    13920

cccactcacc ctagaggacc tggaggaggt ggatctgctc tacgtgcaga ctctcaacag    13980

cattcttcac attgaagaca gtgggattac cgaggagagt ttccatgaga tgattcctct    14040

tgattctttt gttggccaga gtgctgatgg caaaatggtt cctataatcc ctggtggaaa    14100

tagtatccca ctcacatttt ccaacaggaa ggaatatgtg gagagggcca ttgaatatcg    14160

acttcatgag atggacagac aggtggctgc agtccgagaa gggatgtcct ggattgttcc    14220

tgtgccgctg ctgtccctcc tcacagcaaa acaactggag cagatggtgt gtgggatgcc    14280

cgagatctct gtggaagtct tgaagaaagt ggtgcggtac cgtgaggtgg atgagcagca    14340

tcagctggtg cagtggttct ggcacacgct ggaagagttc tccaatgagg agcgggtgct    14400

tttcatgagg tttgtgtcag gaagatctcg actaccagcc aacactgctg acatttctca    14460

gagatttcaa atcatgaagg ttgataggcc ttacgacagt ctgcctacct cacagacctg    14520

cttcttccag ctgaggctgc ccccgtactc cagccagctg gtcatggccg agcgcctgcg    14580

ctatgccatc aacaactgcc gctcaatcga catggacaac tacatgctct cgagaaacgt    14640

ggacaacgcc gagggctccg acactgacta ctgaccgtgc gggtgctctc accctccctt    14700

ctctccctca ataatgctca cttctgattt gatgttgata tacttttatg gtaactacat    14760

agatgttata agaacataaa ccaacattat aaacaatggc cacatttagt tactctaaat    14820

gtaacaaaga aattagatgt ttttattttt ctgtgattgt acaaaaacaa caaaaacgaa    14880

gtgctctcag tcaggttttt ccctccatat ttttggtcac ttttgataag tttgcatgaa    14940

accattttgg tgcattttta gttgggaatg gtacattttt gtaaatccac ccagtgaaca    15000

tgaaattgta cattgtgtat aattgttcat tagaaaggac agttttacat gaatattcat    15060

atatttattt tgttttaatt tgaattgcct gttcagggtt ccttatgcag agaaataaag    15120

cagattcagg aattgga                                                   15137


<210> 3366
<211> 8082
<212> DNA
<213> Homo sapiens

<400> 3366
gcagagtctg cagtgcggag ggggcgggaa gtccaggccc cgcactcgat ccacgctggc       60

tccctacgga ggcccaccta ctcgaggccc accgactcct actgcaatca gtactatgcg      120

atcgtcctag agagtccatt cagctgcact tccgcctcag tatggcatca cagctgcaag      180

tgttttcgcc cccatcagtg tcgtcgagtg ccttctgcag tgcgaagaaa ctgaaaatag      240

agccctctgg ctgggatgtt tcaggacaga gtagcaacga caaatattat acccacagca      300

aaaccctccc agccacacaa gggcaagcca actcctctca ccaggtagca aatttcaaca      360

tccctgctta cgaccagggc ctcctcctcc cagctcctgc agtggagcat attgttgtaa      420

cagccgctga tagctcgggc agtgctgcta catcaacctt ccaaagcagc cagaccctga      480

ctcacagaag caacgtttct ttgcttgagc catatcaaaa atgtggattg aaacgaaaaa      540

gtgaggaagt tgacagcaac ggtagtgtgc agatcataga agaacatccc cctctcatgc      600

tgcaaaacag gactgtggtg ggtgctgctg ccacaaccac cactgtgacc acaaagagta      660

gcagttccag cggagaaggg gattaccagc tggtccagca tgagatcctt tgctctatga      720

ccaatagcta tgaagtcttg gagttcctag gccgggggac atttggacag gtggctaagt      780

gctggaagag gagcaccaag gaaattgtgg ctattaaaat cttgaagaac cacccctcct      840

atgccagaca aggacagatt gaagtgagca tcctttcccg cctaagcagt gaaaatgctg      900

atgagtataa ttttgtccgt tcatacgagt gctttcagca taagaatcac acctgccttg      960

tttttgaaat gttggagcag aacttatatg attttctaaa gcaaaacaaa tttagcccac     1020

tgccactcaa gtacatcaga ccaatcttgc agcaggtggc cacagccttg atgaagctca     1080

agagtcttgg tctgatccac gctgacctta agcctgaaaa catcatgctg gttgatccag     1140

ttcgccagcc ctaccgagtg aaggtcattg actttggttc tgctagtcac gtttccaaag     1200

ctgtgtgctc aacctactta cagtcacgtt actacagagc tcctgaaatt attcttgggt     1260

taccattttg tgaagctatt gatatgtggt cactgggctg tgtgatagct gagctgttcc     1320

tgggatggcc tctttatcct ggtgcttcag aatatgatca gattcgttat atttcacaaa     1380

cacaaggctt gccagctgaa tatcttctca gtgccggaac aaaaacaacc aggtttttca     1440

acagagatcc taatttgggg tacccactgt ggaggcttaa gacacctgaa gaacatgaac     1500

tggagactgg aataaaatca aaagaagctc ggaagtacat ttttaattgc ttagatgaca     1560

tggctcaggt gaatatgtct acagacctgg agggaacaga catgttggca gagaaggcag     1620

accgaagaga atacattgat ctgttaaaga aaatgctcac aattgatgca gataagagaa     1680

ttacccctct aaaaactctt aaccatcagt ttgtgacaat gactcacctt ttggattttc     1740

cacatagcaa tcatgttaag tcttgttttc agaacatgga gatctgcaag cggagggttc     1800

acatgtatga tacagtgagt cagatcaaga gtcccttcac tacacatgtt gccccaaata     1860

caagcacaaa tctaaccatg agcttcagca atcagctcaa tacagtgcac aatcaggcca     1920

gtgttctagc ttccagttct actgcagcag ctgctactct ttctctggct aattcagatg     1980

tctcactact aaactaccag tcagctttgt acccatcatc tgctgcacca gttcctggag     2040

ttgcccagca gggtgtttcc ttgcagcctg gaaccaccca gatttgcact cagacagatc     2100

cattccaaca gacatttata gtatgtccac ctgcgtttca aactggacta caagcaacaa     2160

caaagcattc tggattccct gtgaggatgg ataatgctgt accgattgta ccccaggcac     2220

cagctgctca gccactacag attcagtcag gagttctcac gcagggaagc tgtacaccac     2280

taatggtagc aactctccac cctcaagtag ccaccatcac accgcagtat gcggtgccct     2340

ttactctgag ctgcgcagcc ggccggccgg cgctggttga acagactgcc gctgtactgc     2400

aggcgtggcc tggagggact cagcaaattc tcctgccttc aacttggcaa cagttgcctg     2460

gggtagctct acacaactct gtccagccca cagcaatgat tccagaggcc atggggagtg     2520

gacagcagct agctgactgg aggaatgccc actctcatgg caaccagtac agcactatca     2580

tgcagcagcc atccttgctg actaaccatg tgacattggc cactgctcag cctctgaatg     2640

ttggtgttgc ccatgttgtc agacaacaac aatccagttc cctcccttcg aagaagaata     2700

agcagtcagc tccagtctct tccaagtcct ctctagatgt tctgccttcc caagtctatt     2760

ctctggttgg gagcagtccc ctccgcacca catcttctta taattccttg gtccctgtcc     2820

aagatcagca tcagcccatc atcattccag atactcccag ccctcctgtg agtgtcatca     2880

ctatccgaag tgacactgat gaggaagagg acaacaaata caagcccagt agctctggac     2940

tgaagccaag gtctaatgtc atcagttatg tcactgtcaa tgattctcca gactctgact     3000

cttctttgag cagcccttat tccactgata ccctgagtgc tctccgaggc aatagtggat     3060

ccgttttgga ggggcctggc agagttgtgg cagatggcac tggcacccgc actatcattg     3120

tgcctccact gaaaactcag cttggtgact gcactgtagc aacccaggcc tcaggtctcc     3180

tgagcaataa gactaagcca gtcgcttcag tgagtgggca gtcatctgga tgctgtatca     3240

cccccacagg gtatcgagct caacgcgggg ggaccagtgc agcacaacca ctcaatctta     3300

gccagaacca gcagtcatcg gcggctccaa cctcacagga gagaagcagc aacccagccc     3360

cccgcaggca gcaggcgttt gtggcccctc tctcccaagc cccctacacc ttccagcatg     3420

gcagcccgct acactcgaca gggcacccac accttgcccc ggcccctgct cacctgccaa     3480

gccaggctca tctgtatacg tatgctgccc cgacttctgc tgctgcactg ggctcaacca     3540

gctccattgc tcatcttttc tccccacagg gttcctcaag gcatgctgca gcctatacca     3600

ctcaccctag cactttggtg caccaggtcc ctgtcagtgt tgggcccagc ctcctcactt     3660

ctgccagcgt ggcccctgct cagtaccaac accagtttgc cacccaatcc tacattgggt     3720

cttcccgagg ctcaacaatt tacactggat acccgctgag tcctaccaag atcagccagt     3780

attcctactt atagttggtg agcatgaggg aggaggaatc atggctacct tctcctggcc     3840

ctgcgttctt aatattgggc tatggagaga tcctccttta ccctcttgaa atttcttagc     3900

cagcaacttg ttctgcaggg gcccactgaa gcagaaggtt tttctctggg ggaacctgtc     3960

tcagtgttga ctgcattgtt gtagtcttcc caaagtttgc cctattttta aattcattat     4020

ttttgtgaca gtaattttgg tacttggaag agttcagatg cccatcttct gcagttacca     4080

aggaagagag attgttctga agttaccctc tgaaaaatat tttgtctctc tgacttgatt     4140

tctataaatg cttttaaaaa caagtgaagc ccctctttat ttcattttgt gttattgtga     4200

ttgctggtca ggaaaaatgc tgatagaagg agttgaaatc tgatgacaaa aaaagaaaaa     4260

ttactttttg tttgtttata aactcagact tgcctatttt attttaaaag cggcttacac     4320

aatctccctt ttgtttattg gacatttaaa cttacagagt ttcagttttg ttttaatgtc     4380

atattatact taatgggcaa ttgttatttt tgcaaaactg gttacgtatt actctgtgtt     4440

actattgaga ttctctcaat tgctcctgtg tttgttataa agtagtgttt aaaaggcagc     4500

tcaccatttg ctggtaactt aatgtgagag aatccatatc tgcgtgaaaa caccaagtat     4560

tctttttaaa tgaagcacca tgaattcttt tttaaattat tttttaaaag tctttctctc     4620

tctgattcag cttaaatttt tttatcgaaa aagccattaa ggtggttatt attacatggt     4680

ggtggtggtt ttattatatg caaaatctct gtctattatg agatactggc attgatgagc     4740

tttgcctaaa gattagtatg aattttcagt aatacacctc tgttttgctc atctctccct     4800

tctgttttat gtgatttgtt tggggagaaa gctaaaaaaa cctgaaacca gataagaaca     4860

tttcttgtgt atagctttta tacttcaaag tagcttcctt tgtatgccag cagcaaattg     4920

aatgctctct tattaagact tatataataa gtgcatgtag gaattgcaaa aaatatttta     4980

aaaatttatt actgaattta aaaatatttt agaagttttg taatggtggt gttttaatat     5040

tttacataat taaatatgta catattgatt agaaaaatat aacaagcaat ttttcctgct     5100

aacccaaaat gttatttgta atcaaatgtg tagtgattac acttgaattg tgtacttagt     5160

gtgtatgtga tcctccagtg ttatcccgga gatggattga tgtctccatt gtatttaaac     5220

caaaatgaac tgatacttgt tggaatgtat gtgaactaat tgcaattata ttagagcata     5280

ttactgtagt gctgaatgag caggggcatt gcctgcaagg agaggagacc cttggaattg     5340

ttttgcacag gtgtgtctgg tgaggagttt ttcagtgtgt gtctcttcct tccctttctt     5400

cctccttccc ttattgtagt gccttatatg ataatgtagt ggttaataga gtttacagtg     5460

agcttgcctt aggatggacc agcaagcccc cgtggaccct aagttgttca ccgggattta     5520

tcagaacagg attagtagct gtattgtgta atgcattgtt ctcagtttcc ctgccaacat     5580

tgaaaaataa aaacagcagc ttttctcctt taccaccacc tctacccctt tccattttgg     5640

attctcggct gagttctcac agaagcattt tccccatgtg gctctctcac tgtgcgttgc     5700

taccttgctt ctgtgagaat tcaggaagca ggtgagagga gtcaagccaa tattaaatat     5760

gcattctttt aaagtatgtg caatcacttt tagaatgaat ttttttttcc ttttcccatg     5820

tggcagtcct tcctgcacat agttgacatt cctagtaaaa tatttgcttg ttgaaaaaaa     5880

catgttaaca gatgtgttta taccaaagag cctgttgtat tgcttaccat gtccccatac     5940

tatgaggaga agttttgtgg tgccgctggt gacaaggaac tcacagaaag gtttcttagc     6000

tggtgaagaa tatagagaag gaaccaaagc ctgttgagtc attgaggctt ttgaggtttc     6060

ttttttaaca gcttgtatag tcttggggcc cttcaagctg tgaaattgtc cttgtactct     6120

cagctcctgc atggatctgg gtcaagtaga aggtactggg gatggggaca ttcctgccca     6180

taaaggattt ggggaaagaa gattaatcct aaaatacagg tgtgttccat ctgaattgaa     6240

aatgatatat ttgagatata attttaggac tggttctgtg tagatagaga tggtgtcaag     6300

gaggtgcagg atggagatgg gagatttcat ggagcctggt cagccagctc tgtaccaggt     6360

tgaacaccga ggagctgtca aagtatttgg agtttcttca ttgtaaggag taagggcttc     6420

caagatgggg caggtagtcc gtacagccta ccaggaacat gttgtgtttt ctttattttt     6480

taaaatcatt atattgagtt gtgttttcag cactatattg gtcaagatag ccaagcagtt     6540

tgtataattt ctgtcactag tgtcatacag ttttctggtc aacatgtgtg atctttgtgt     6600

ctcctttttg ccaagcacat tctgattttc ttgttggaac acaggtctag tttctaaagg     6660

acaaattttt tgttccttgt cttttttctg taagggacaa gatttgttgt ttttgtaaga     6720

aatgagatgc aggaaagaaa accaaatccc attcctgcac cccagtccaa taagcagata     6780

ccacttaaga taggagtcta aactccacag aaaaggataa taccaagagc ttgtattgtt     6840

accttagtca cttgcctagc agtgtgtggc tttaaaaact agagattttt cagtcttagt     6900

ctgcaaactg gcatttccga ttttccagca taaaaatcca cctgtgtctg ctgaatgtgt     6960

atgtatgtgc tcactgtggc tttagattct gtccctgggg ttagccctgt tggccctgac     7020

aggaagggag gaagcctggt gaatttagtg agcagctggc ctgggtcaca gtgacctgac     7080

ctcaaaccag cttaaggctt taagtcctct ctcagaactt ggcatttcca acttcttcct     7140

ttccgggtga gagaagaagc ggagaagggt tcagtgtagc cactctgggc tcatagggac     7200

acttggtcac tccagagttt ttaatagctc ccaggaggtg atattatttt cagtgctcag     7260

ctgaaatacc aaccccagga ataagaactc catttcaaac agttctggcc attctgagcc     7320

tgcttttgtg attgctcatc cattgtcctc cactagaggg gctaagcttg actgccctta     7380

gccaggcaag cacagtaatg tgtgttttgt tcagcattat tatgcaaaaa ttcactagtt     7440

gagatggttt gttttaggat aggaaatgaa attgcctctc agtgacagga gtggcccgag     7500

cctgcttcct attttgattt tttttttttt taactgatag atggtgcagc atgtctacat     7560

ggttgtttgt tgctaaactt tatataatgt gtggtttcaa ttcagcttga aaaataatct     7620

cactacatgt agcagtacat tatatgtaca ttatatgtaa tgttagtatt tctgctttga     7680

atccttgata ttgcaatgga attcctactt tattaaatgt atttgatatg ctagttattg     7740

tgtgcgattt aaactttttt tgctttctcc ctttttttgg ttgtgcgctt tcttttacaa     7800

caagcctcta gaaacagata gtttctgaga attactgagc tatgtttgta atgcagatgt     7860

acttagggag tatgtaaaat aatcatttta acaaaagaaa tagatattta aaatttaata     7920

ctaactatgg gaaaagggtc cattgtgtaa aacatagttt atctttggat tcaatgtttg     7980

tctttggttt tacaaagtag cttgtatttt cagtattttc tacataatat ggtaaaatgt     8040

agagcaattg caatgcatca ataaaatggg taaattttct ga                        8082


<210> 3367
<211> 2391
<212> DNA
<213> Homo sapiens

<400> 3367
gtccctctct ggccaccgca cgacgggcgc agaaatctgg gccccagagc tgcgctgaga       60

gatcccccga cgcttcccca gcctcccagg gaggccttcg cggagtcggg gcgtcgcggg      120

tcggggcgct cgctgtgtcc cttcagctcc agactgcgtg aagctcctcc agcaggcccc      180

agcgcccagg gattttgtcc taaaaaaggg tcatggagtg ggtggattgc gggcggcccg      240

gcgctttttc tgcatacgga tttcgtccca aatttgctaa catgagaacc acagtttttc      300

agaagagcag aatgtttatt tgccaagacc tgtttggcag gtgtgaatgt tttagagaag      360

aaatgccgag aaaatgctgg cattttgcgt tgcgggtttt tttttaaatt gagaaatagg      420

ttactggctt actttgtttc tccagaatat tttcacttgg ctttaattta agtcatgtgg      480

ctttaatttc cttccagatt atgcgttcag atgtggcaaa ggcttaagag aatcattatc      540

tcttaatcgt agcggttttg attatctttt ttcccacatc atatttttct ttctttcttt      600

ttaaatcaca gctttacgtt tttaagagtc tctatctggt tcattgattg attcaacaaa      660

tatttattaa gtgtctaata tgtgccaggc atagttgctg gggatgcagc aggaaacaac      720

gcagaatttt tggccttctt ggaaatgggc agtaagcaga atgatatcct gagagaagat      780

gggaaagggc tgcaaggttg tggtttgtgg attgttatct gtggggaaaa ctgcaatttt      840

ggagcagctc ctttatggaa atcatactat tggaatggaa gattgcgaaa caatggaaga      900

tgtatacatg gcttcagtag aaacagaccg aggagtaaaa gaacagttac atctttatga      960

caccagaggt ctacaggaag gcgtggagct gccaaagcat tatttttcat ttgctgatgg     1020

cttcgttctt gtgtacagtg tgaataacct tgaatccttt caaagagtgg agcttctgaa     1080

gaaagaaatc gataagttca aagacaaaaa agaggtagca attgtggtat taggaaacaa     1140

aatcgacctt tctgagcaga gacaagtgga cgctgaagtg gcacagcagt gggcaaaaag     1200

tgagaaagta agactgtggg aggtgactgt tacagatcgg aaaactctga ttgaaccatt     1260

cactttatta gccagtaaac tttctcaacc ccagagcaaa tcaagctttc ctttgcctgg     1320

gaggaaaaac aaagggaact ctaattctga gaactaaaaa tcagtaattt ccacaattgt     1380

atgttgaata gtgattgcct ttaagtgtct gtgaacatgg agtaatatta ctatttaaaa     1440

taggccattt gtatctacct ttggtcctta ggaaaattcc taaggaagtc aattaatgca     1500

ctttagatgt taaaagtatt tgggctaagg ttattattgc ctgatatgaa ataatatatt     1560

cttattctca ttgtttgaaa cctgtctttg aaattagcac ctttgttatt tatgttgtac     1620

ttgtgaaaac agtaaaatag tttggatagt tatgcaaatg cacctatgtg taacttcccc     1680

ccaaccccaa gctgtttcgg aagatatcat aatcattctg tgtaacatta tgcaaacttc     1740

taagcccaaa catgactttg tttttaaaaa gttcattaat ctaatgtcta ggattataaa     1800

acattttttt gtgtctaaat tggacccaaa acattgaaca gtttggggta gtaagctaaa     1860

tttcatcttg tggagatttt gctaaacaga ctaagaccca tgatttagct ttgctcaaat     1920

tagaatgttt agcatgagtt gaggtaccag gtagtgttaa gtaggttcat cacgctctaa     1980

ggccgttttt tccttagcca gacccctgtt gatagaccag atacttgagg gcaaactgtt     2040

tgctcctcct cttgaaaatg attaggcact taaggacagt aaagctgtat tttctggaag     2100

gaagactgta tcttctggaa tagttttcta gaaaactagt catatacaat aaaagtatca     2160

aaaatattgg gctctaattt gatctgactt agatgtctga gtttgtgttg tttctctaaa     2220

gattttggca agactcaagc aatgtggctg actgtaactt tattaattta aaaggtagga     2280

agtaagctac ttagtggttt cacctgtgaa ataactattt tgactgaaat gtaaaataag     2340

ctattcaaca aagaacatat taaaacatca agtaatttgt aacatcttaa a              2391


<210> 3368
<211> 2163
<212> DNA
<213> Homo sapiens

<400> 3368
gacgccgatg cggagctgag ctggctttcc tccagggctc tggactccct gctgagcaag       60

agagaaagag gcccgccctt ccaccaggac gcctgaccct ggggtccttc ccaaacccgg      120

gtctcttccg actccgggcc caacagtttg tgcgattaaa gtgaagaaac aatggccagc      180

aatcacaaat cttcagcagc tcgccctgtt tcaagaggtg gagttgggtt aacaggaagg      240

cctccttctg ggatacgacc cctatcagga aatattcgag tggcaactgc aatgccacct      300

gggacagcaa gaccaggttc tcgtggttgt cccataggga ctggtggagt tctgtcttct      360

caaatcaaag ttgcccatcg ccctgtaaca caacaaggtt tgactggaat gaaaactggg      420

acgaaaggtc cccagaggca aattttagac aaatcttact atcttgggct tcttagaagt      480

aaaataagtg aacttacaac tgaagttaat aaacttcaga agggaataga aatgtacaat      540

caagagaatt cagtatattt gtcatatgaa aagagggctg agactttagc tgttgagata      600

aaagagcttc aaggacaact agcagactac aacatgttgg tagataaact taataccaac      660

actgaaatgg aagaagtaat gaatgattac aatatgctta aagctcaaaa tgatcgagaa      720

acacaaagtt tggatgtcat atttactgaa agacaagcga aagaaaaaca aatcagaagt      780

gtcgaagaag aaattgaaca ggaaaaacaa gcaacagatg acattatcaa aaatatgtct      840

tttgaaaacc aagtcaagta cctagagatg aaaaccacaa atgagaaact gttacaggaa      900

ttagatacac ttcaacaaca attggattca cagaacatga aaaaagagag cctggaagca      960

gaaatagctc actcccaggt gaaacaggag gcggtattgc tgcatgaaaa actttatgag     1020

ttggagtccc atcgagatca aatgattgca gaagacaaaa gcataggatc tccaatggaa     1080

gagagagaga aattacttaa gcagattaaa gatgataatc aggaaatagc cagcatggaa     1140

agacagttaa cagatacaaa agaaaagata aatcagttta ttgaagaaat tagacaactt     1200

gacatggatt tagaggaaca ccaaggtgaa atgaaccaga aatacaagga gctaaagaaa     1260

agggaggaac atatggacac ttttattgag acttttgagg aaacaaagaa tcaggaactg     1320

aaacgaaagg cacagataga agccaacatt gttgcactct tggagcactg cagtcgaaat     1380

ataaatcgta tagaacagat atcctctatc accaatcaag agctaaagat gatgcaggat     1440

gacctcaatt ttaaatctac tgaagtgcag aaatcacaaa gtacagctca gaatttgact     1500

tcagacattc aacgtctgca gttggatctg cagaaaatgg agcttctaga aagtaagatg     1560

actgaagaac agcattctct aaaaagcaaa attaagcaaa tgacaactga tctggagata     1620

tataatgatt tgccagcttt aaaatcatca ggtgaagaaa agataaagaa attacatcag     1680

gagagaatga tattatcaac ccacagaaat gcctttaaga aaataatgga gaagcaaaac     1740

atagagtatg aggcactaaa aacacaattg caagaaaatg agacacattc tcagcttaca     1800

aatttggaga gaaagtggca acaccttgag caaaataatt ttgcgatgaa agaattcata     1860

gcaaccaaga gtcaagagag tgattaccag ccaattaaga aaaatgtgac caagcagatt     1920

gcagagtaca ataaaaccat cgtggatgct ttacatagca ccagcggaaa ctgagtttaa     1980

gtccactgaa agtctctaag gaagtatcct cttgctgcta aacttggtac aagttgacta     2040

ccaaaaaaaa aaaaagctta cttttggagt ttacctaaaa tttctgaatg ttataatttt     2100

tgtggcctct tttaagaatg atattttaaa atagtaaata gttcaataaa tggtttgcat     2160

att                                                                   2163


<210> 3369
<211> 1647
<212> DNA
<213> Homo sapiens

<400> 3369
atgctgctgc tgccgggtgt ccatggcccg cacccccaag ctgccactgc agcagtcaga       60

gtggcagctg aaggctcggt tcatgccgtg cccccgggca gttctggtga ggctaagcaa      120

gaggcctctg catcttgaca cctaggagag cagggacgga gtctcccagg gtggaggacc      180

atgctgcgcc gcaagccctc caatgccagt gagaaggagt ttaatctgga tgataacatt      240

ccagaagatg actcaggtgt ccccacccca gaagatgctg ggaagagtgg caaaaagctg      300

gggaagaagt ggagggcagt gatttcccga accatgaaca ggaagatggg caagatgatg      360

gtgaaggccc tgtcagaaga gatggcagac actctggagg agggctctgc ctccccgaca      420

tctccagact acagcctgga cagccctggc cctgagaaga tggcgctggc cttttctgag      480

caagaggagc atgaacttcc ggtgctcagc cgccaggcat caacaggcag tgagctctgc      540

agccccagcc caggttctgg cagcttcggg gaggaaccac ctgcccccca gtacacaggg      600

cctttctgtg gccgggcacg agtccacacc gacttcactc ccagccccta tgaccacgac      660

tcgctgaaac tgcaggtaag atcagcatcc gggcttctct ggagcctggc aggctgtgcc      720

caaaaaggaa gctggactga accaggctat gacagtgtca gtggaggcca aggcccccca      780

tatcctctct cccttgctcc cttctcctct cctctccccc aacagaaagg agatgtgatc      840

cagatcattg aaaagccacc tgtgggcacg tggctgggcc tactcaatgg caaggtgggc      900

tctttcaaat tcatctatgt ggatgtgctg cccgaggagg ccgtggggca tgcccgcccc      960

agccgccgac agagcaaggg caagaggccc aagcctaaga ccctgcatga gctgctggag     1020

cgcatcggcc tggaggagca cacatccacc ctcctgctca atggctacca gacactggaa     1080

gacttcaaag agctgcgaga aacacacctc aatgagctga acatcatgga tccacagcac     1140

cgggccaagc tgctcacggc cgccgagctg ctgctggact atgacactgg cagtgaggag     1200

gctgaagagg gcgccgagag cagccaggag ccagtggcac acacagtgtc ggaacccaag     1260

gtggacatcc cgcgcgactc aggctgcttt gagggctcgg agagcgggcg cgatgacgca     1320

gagctggcag gcactgagga gcagctgcaa ggcctctccc tggccggggc accttgaggt     1380

ggcggtggca ataggccaag gctgggaccc agctgcaaag gctgtaggag tggggtttat     1440

cgaggggacc agaggggcct caggctttca gatgaaatgg ctcctcctac tcacccactt     1500

tattcctctc catgtaattc aggacaagct gcaacttccc ccagcttaac acaatgccca     1560

tacctcatac gatatgcgcc ctcccgttcc atccctggcc ccctcaaacg agacttctca     1620

caaggctgat tacagatggt caaacct                                         1647


<210> 3370
<211> 1521
<212> DNA
<213> Homo sapiens

<400> 3370
gttgcggcag tcgcgtcccg ggagcgtcgc tgcctggtga acgctagaat gggtactagg       60

aaaaaagttc atgcatttgt ccgtgtcaaa cccaccgatg actttgctca tgaaatgatc      120

agatacggag atgacaaaag aagcattgat attcacttaa aaaaagacat tcggagagga      180

gttgtcaata accaacagac agactggtcg tttaagttgg atggagttct tcacgatgcc      240

tcccaggact tggtttatga gacagttgca aaggatgtgg tttctcaggc cctcgatggc      300

tataatggca ccatcatgtg ttatgggcag acgggagctg gcaagacata caccatgatg      360

ggggcaactg agaattacaa gcaccggggg atcctccctc gtgccctgca gcaggttttt      420

aggatgatcg aagaacgccc cacacatgcc atcactgtgc gtgtttccta cttggaaatc      480

tataatgaga gcctgtttga tctcctgtcc actctgccct atgttggacc ctcagtcaca      540

ccaatgacca tcgtggaaaa ccctcaagga gtcttcatta agggcttgtc agttcacctc      600

acaagtcagg aggaggatgc attcagcctc ctttttgagg gtgagaccaa caggattata      660

gcctcccaca ctatgaacaa aaactcttcc agatcacact gcattttcac catctactta      720

gaggcccatt cccggacctt atcagaggaa aagtacatca cttccaaaat taacttggtg      780

gatctggcag gctcagagag gctggggaag tctgggtctg agggccaagt cctgaaggaa      840

gccacctaca tcaacaaatc gctctcattc ctggagcagg ccatcattgc ccttggggac      900

cagaagcggg accacatccc ctttcggcag tgcaagctca cccacgctct gaaggactcg      960

ttagggggaa actgcaatat ggtcctcgtg acaaacatct atggagaagc tgcccagtta     1020

gaagaaacgg gttccaggct gtggttataa ggccagtatg agcagatggt attaagcacc     1080

tgccatgtgc accatgctat cttcactgag atttgccagc aggatgaagc tagtcaccac     1140

tgagcctgcc atcaatgaaa agtatgatgc tgaggaatgg ccaggatgtc tgggcacaga     1200

atgaggaatt gtacttttgc tgtggaagag acagggtagc ttctctgatg atccttcctg     1260

tcggccccca ccctaccatg tttcccggca gagaatggtc aagaacctgg agaaggaact     1320

agcactactc aagcaggagc tggctatcca tgacagcctg accaaccgca cctttgtgac     1380

ctatgacccc atggatgaaa tccagattgc tgagatcaac tcccaggtgc ggaggtacct     1440

ggaggggaca ctggacgaga tcgacataat cagccttaga cagatcaagg aggtgttcaa     1500

ccagttccgg gtggttctga g                                               1521


<210> 3371
<211> 2755
<212> DNA
<213> Homo sapiens

<400> 3371
cgccgctcgc tccgcccccc gcccggaagc tcccgcccga gcccgcgcag gccctggggc       60

cgaccttcct gccgggccgg gcggtccgag gctgctggag tgccgtgagc aggccgcggg      120

aacgtcgccg tcaccttgtc tcggggcctc ggcgctgctt cccgccaaaa cacgtttacc      180

gcgcgcccgg gcctcccacc ttgcggaagg gaccccacca ccacttggat ttctgttgca      240

ggttgagaac aaaaacatgc acctggagtt tccccggagc cctctgcgtg gttgagcttc      300

ggtggaattt cggggctctt ggctgccagc cgcgcttgcc tggtagcaac agaaaccagt      360

cctgctcgcc tccgtggaca tttcattacc atccagaagt gtctcccact gaaggcatcc      420

gtggttgttt ttaagccaca aaaaagccac acccaagatc acctgacacc caccctgaca      480

agtgtccatg atgctgggcc ctgagggagg tgaaggcttt gtggtcaagc tccgtggcct      540

gccctggtcc tgctctgttg aggacgtgca gaacttcctc tctgactgca cgattcatga      600

tggggccgca ggtgtccatt tcatctacac tagagagggc aggcagagtg gtgaggcttt      660

tgttgaactt ggatcagaag atgatgtaaa aatggccctg aaaaaagaca gggaaagcat      720

gggacaccgg tacattgagg tgttcaagtc ccacagaacc gagatggatt gggtgttgaa      780

gcacagtggt cccaacagtg ccgacagcgc caacgatggc ttcgtgcggc ttcgaggact      840

cccatttgga tgcacaaagg aagaaattgt tcagttcttc tcagggttgg aaattgtgcc      900

aaacgggatc acattgcctg tggaccccga aggcaagatt acaggggaag cgttcgtgca      960

gtttgcctcg caggagttag ctgagaaggc tctagggaaa cacaaggaga ggatagggca     1020

caggtacatt gaggtgttta agagcagcca ggaggaagtt aggtcatact cagatccccc     1080

tctgaagttc atgtccgtgc agcggccagg gccctatgac cggcccggga ctgccaggag     1140

gtacattggc atcgtgaagc aggcaggcct ggaaaggatg aggcctggtg cctacagcac     1200

aggctacggg ggctacgagg agtacagtgg cctcagtgat ggctacggct tcaccaccga     1260

cctgttcggg agagacctca gctactgtct ctccggaatg tatgaccaca gatacggcga     1320

cagtgagttc acagtgcaga gcaccacagg ccactgtgtc cacatgaggg gcctgccgta     1380

caaagcgacc gagaacgaca tttacaactt cttctctcct ctcaaccctg tgagagtcca     1440

tattgagatt ggcccagatg gaagagtgac gggtgaagca gatgttgagt ttgctactca     1500

tgaagaagct gtggcagcta tgtccaaaga cagggccaat atgcagcaca gatatataga     1560

actcttcttg aattcaacaa caggggccag caatggggcg tatagcagcc aggtgatgca     1620

aggcatgggg gtgtctgctg cccaggccac ttacagtggc ctggagagcc agtcagtgag     1680

tggctgttac ggggccggct acagtgggca gaacagcatg ggtggctatg actagttttg     1740

ttaggaacat ttgagttact tcaatcattt tcacaggcag ccaacaagca attaagagca     1800

gttataatag aggaagctgg gggacccatt ttgcaccatg agtttgtgaa aaatctggat     1860

taaaaaatta cctcttcagt gttttctcat gcaaaatttt cttctagcat gtgataatga     1920

gtaaactaaa actattttca gcttttctca attaacattt tggtagtata cttcagagtg     1980

atgttatcta agtttaagta gtttaagtat gttaaatgtg gatcttttac accacatcac     2040

agtgaacaca ctggggagac gtgctttttt ggaaaactca aaggtgctag ctccctgatt     2100

caaagaaata tttctcatgt ttgttcattc tagtttatat tttcatttaa aatcctttag     2160

gttaagttta agctttttaa aagttagttt tgagaattga gacacaatac taatactgta     2220

ggaattggtg aggccttgac ttaaaacttt ctttgtactg tgatttcctt ttgggtgtat     2280

tttgctaagt gaaacttgtt aaattttttg ttaactaaat ttttttctta aaataaagac     2340

tttttcacaa tgactggcac agattactca gcaaaagata gcaaaacggg tggttgaaga     2400

taattcattt taatcgtaat gtattttagt gtgaatttaa aaatttcata catcaaatct     2460

atgatctccc ttatattctt atgatgaggc taaataaaag tctaataaaa atgttaaata     2520

tgtgaatggt ggaaatggtg actagcagca cacattctgg gaagcatcaa atagacacac     2580

ggccccagcc acctgcaact tatgtgcact gttgtaaacc attcagaatt ttcctgctag     2640

gcccttgatg ctggagtcac atctgttgat agctggagaa ctttagtttc aagtactaca     2700

ttgtgaaagc aattattttg tttctagttt ttataaaatg ctgatttaaa ctttt          2755


<210> 3372
<211> 3678
<212> DNA
<213> Homo sapiens

<400> 3372
aatctctact cggcccgcac cagcagcgct ggcgtcaggg cgcggtgggg gcaagacggg       60

tgactggcag cagggcggtg ccgggccgag aagggcgcct cacctggcgc ctcctgcctt      120

cctttccacc tcaggttgca gagagccgcc agggcaggtg gaagggccac gccccgctcc      180

cgtgagggtc accgagagac gttgggggtg gggcagggac cccaacccta gaccagtcct      240

gtagggcaca atgtctgaac aagagcgtat acaggaatgt ctgcggaagg aaataaggtc      300

acttctcatt tccaccaaag atggtttgag cccacaggag ttggagaagg agtacctttt      360

gatggttggc aaccatctac cactccgaat ccttgggtat cggtccacta tggagctggt      420

attggacatg cctgatgttg ttcgtgtctg ccccggtgca ggtggtactg taatactgaa      480

agccattcca gatgaatcta ccaaaggaat agcaagctta gttgcaaaac agaggagcag      540

ccataagctt cgaaactcaa tgcataaggg aagacctagt atttattctg gaccgagatc      600

tcatcggcga gtaccttacc gaggaagggt tgcccctatt cttccagctg ttgtgaagag      660

tgagttgaag gacctgttgg cgttatctcc tgttcttctt tctgattttg aaaaggcatt      720

tgccaaaaga tttggacgat cattccaata catgcaatat ggatttctct ctatgtttga      780

agtgcttaat gcggcttcag atgtcatttc tgtagagcag accagagcag gttctttgtt      840

gatgctaaag aagagtgtaa cagaggaaaa gccgagagga tgtccagcag gtaaaatttt      900

tacccagcca tttagaatga aacaagggtc atactccaca ggctttccgg tagcaaagcc      960

atgcttttca caacccactt caaacatgga accaccgaag caaataatga gcatggaaaa     1020

gacttccaag ttaaatgtag tggagacttc aagactgaat cacactgaaa aattaaacca     1080

gctggagaac acattcaaat cagttattgc acagattgga cctggaggaa ctatcagttc     1140

agaactaaaa cataagataa aatttgttgt atctaagttc ccagagggtt tgtttatttc     1200

taaactgctt ggagagtatg aggtaatttt taaagagcaa ctatcaccaa aaaaattagg     1260

cttcttaaat gtgacagaac ttgttggagc tcttagtgac attctccatg ttgagttcag     1320

gaaaggacac caagacttac tagtgtttga tgcggataag aagcctctac cacctgttca     1380

gtcagataag aaaatagaag ccaaagcttg tgtctccagt ccacctagaa attcattgtc     1440

tactgctgct gtcaaagaga ctgtatggaa ttgcccttca aaaaaacaaa aagagccaca     1500

acagaagatt tgcaagaagc ctaatctggt ggtaaagcct ttacagctgc aagtagaaac     1560

aaacaaatca gagctcaact tggcaatggc aaatcatgac atcccgccag acgctgtgcc     1620

gaacaagaaa ttatgcagac tcccaccatt agacaccagt tccctcatag gggtctttgt     1680

ggagtatatc atctctccta gtcaattcta catccggatc tatagcaggg attcgtcaga     1740

gttactcgaa gacatgatga ttgaaatgcg gcgctgttat tctaatcagc tggtttctga     1800

tcgatatgtc atgccagaat gttttattca gccgggacat ctctgttgtg taaggatttc     1860

tgaggataag tggtggtatc gggtcattat ccatcgagtc cttgagaaac aggaagttga     1920

agtgttctac ccagactttg gaaatattgg aattgttcag aagtcctccc tgaggttcct     1980

caagtgctgc tacacaaagc ttccagctca ggctatccct tgttctttgg cttgggtgag     2040

accagtagag gaacactgga catcgaaagc tattttgcag ttccagaagt tgtgcggttt     2100

gaagccatta gtgggggtag tggatgaata tgtagatgga atccttaaca tttttttgtg     2160

tgacacatcc tcaaacgaag atgtctattt ccatcatgtc ttgagaacag agggccatgc     2220

tattgtatgc cgagaaaata tctcttctaa gggtttcagt gagctcaacc ctttagcttt     2280

atacacgaca tccagtggag ggccagagga cattgtcttg acagaactgg gttatccttc     2340

ccagcagcac tattttaatg aagaccgaaa gataagtcca cagtcaaaag agagtgagtt     2400

acgtatcttg caagatatta atgatgaaaa gtctttaagt catcttaaat ctgagtcaaa     2460

ggagccatta aaggattctg aatttgagtc tttgaaaacc tgtaataaga gctttgaaga     2520

agatccaaag tggtccaacc cagaaccaaa cgatctgaag gaagaaaatg aggatgagat     2580

ccccactgga atgccatgcc tggagtcagt gaccataggt gatgatattt gggatgagaa     2640

ctggttacct ctacaggcta agatgggaaa aggaggtgat gctgcctccc atctatttac     2700

tgcaagcctt ggtggaaaga atcagtattc atcatgtaaa gaaatgccac agaaggactg     2760

gtgtttttct acccctaaag atacatggga tgattcttgg cagccttcag gccttgtaaa     2820

tggaacgaaa gtagaagttc ataagccaga agtactgggt gctcaggaaa aaaatactgg     2880

cacaaacagg actcaaaagc aactagacat aaatggttct tcagattctt ccacactgcc     2940

caaattggaa gaattctgta cctctcttac ccagtcagag cagtcagcag acgggagcca     3000

gtctgaaccc aacaacagtc agactcagcc aaagcaaatt cagctttcca cagcagcacc     3060

ctgttcaaca actgcagtgg atgattccgc agaaaagccc tctggttctg tggaaagctc     3120

accagagatc ctaaagaatg aagatttttc tagcagccgt gctattacat tgtacaaaga     3180

caagcgtcaa gaatctgtag accagctgtc tttgattttg tcttatgagt gccagatttc     3240

tcagaagctc tacattcctc gaagtacagc cactgctgcc ttaggtgctg ccgcacggtt     3300

agctacatcc aggagcctcc tacactggta ccccagtgtg aaaaggatgg aagcatgagg     3360

gagggaggga ggagggagaa aaacagaatc cagccgctta ggctttgatg aactcccagg     3420

ccaaaatgag gagttattga agcaaaatag tatcttgatc attgatactt ttgtctttct     3480

gtgactatat gttagcttta ttatgctaac agtctacttt gatgtgtaag taagtattga     3540

tatttactgt taatcttgat ttttcttgat tttattctgt gtcattttgt tcacctttgt     3600

ttttaatgta gtttaaagga atttgttttt ttgtgtttgt ttttcttgta cattatcatg     3660

actgataaat gaaaattg                                                   3678


<210> 3373
<211> 1204
<212> DNA
<213> Homo sapiens

<400> 3373
gagacggaag tttacgacgc ccagagcgct ccttctggac gtgccctgga ctcgacttgg       60

gactgagtct gtgccgccta ggctggcagg gactcggcca gatgcactag cggcaaggct      120

gggctgacac cgcctgggac tcgctcgccg tacctccaag gggcccaggt catgaggggg      180

cggctgggga gacgcccgcc cggtgcccgc cctgggcccg gcgggtgccc cctgcccgcc      240

gcctgacgca atccgaggcg cccttgctgc atgccggcgc tggagaaacc tcccctgccg      300

ttgcatcact cctgccaggt ttgccacaga ggtggagctg aaccaatcag cgggcgcgct      360

gggcccgcgg cgcggttaag tgagaagcag aatccgaagt tgattggcca aaaggggatt      420

tgccccaccc caatcaccgc ggcagctggc cgcggtgggc gtggtctccc ggcaagaagg      480

tttaaagggc gcctccatgg ggggcgctca gctggagcta ccgagcggtg ccaggccagg      540

tgtgtgcgtc cgtcggtctt tccgtgccca cgccggagac cagccccgga ggccgcctgg      600

gcctatccct gtgccaggca ccatgaagca ggagtctgca gccccgaaca ccccgcccac      660

ctcgcagtcc cctacgccgt ccgctcagtt cccccgaaac gacggcgacc ctcaagcgct      720

gtggattttc gggtacggct ccctggtgtg gaggcccgac ttcgcctaca gcgacagccg      780

tgtgggcttc gtgcgcggct acagccgccg tttctggcag ggagacacct tccatcgggg      840

cagcgacaag atgcctggcc gtgtggtgac gctccttgaa gatcatgagg gctgcacttg      900

gggcgtggca taccaagtgc aaggggagca gaaccctggt tacctgggcc ctgcgcctga      960

agaggccatt gccacgcaga tcctggcctg ccggggcttc tccggccaca accttgaata     1020

cttgctgcgt ctggcagact tcatgcagct ctgtgggcct caggcgcagg acgagcacct     1080

ggcagccatc gtggacgctg tgggcaccat gttgccctgc ttctgcccca ccgagcaggc     1140

tctggcgctg gtgtgagggg ctgagcccct gcggggagtg ctcatgtgga catcagggcc     1200

agac                                                                  1204


<210> 3374
<211> 3182
<212> DNA
<213> Homo sapiens

<400> 3374
aatgtttatg catagaaata tagctgaggt ggatgtggtt gctgtcagct attcaggttt       60

gctacctgat cacctcctga agatgtaggg ttgacgatgt gtcacactgt gtaagggaat      120

cgcatggaga tgggcattcc gaactgttaa tggggacatg ggactccagt tgtctctgat      180

cacttgtgtg gattttcctg gcgtagaacg acagaagccg ctagtaagtc gccaagacct      240

acagcaggaa ttctgcacca aagggcataa aatcttgtta ttttaatttg catctgggag      300

aatgtctgag caaggagacc tgaatcaggc aatagcagag gaaggaggga ctgagcagga      360

gacggccact ccagagaacg gcattgttaa atcagaaagt ctggatgaag aggagaaact      420

ggaactgcag aggcggctgg aggctcagaa tcaagaaaga agaaaatcca agtcaggagc      480

aggaaaaggt aaactgactc gcagccttgc tgtctgtgag gaatcttctg ccagaccagg      540

aggtgaaagt cttcaggatc aggaatcaat tcatttacag ctttccagtt tttccagcct      600

gcaagaggag gataaatcta ggaaagatga ctctgaaaga gaaaaagaaa aggataaaaa      660

caaagataaa acctctgaaa aacccaagat cagaatgtta tcaaaagatt gcagccaaga      720

atacacggat tctacaggca tagacttaca cgagtttctg attaacacat taaagaataa      780

ttccagggac aggatgatac ttttgaaaat ggagcaggaa attattgatt tcattgctga      840

caacaataat cattataaaa agttccctca gatgtcatcg tatcagagga tgcttgtcca      900

tcgagtggca gcttattttg gattggatca caatgtggat caaacaggaa aatctgttat      960

catcaacaag accagcagca ccagaatacc agagcaaagg ttttgtgaac atttaaaaga     1020

tgaaaaaggt gaagaatccc agaagcggtt tatcttgaag cgagataact ctagtattga     1080

taaagaagac aatcagtcag tttgctccca ggaaagcctt tttgtggaaa acaggggcaa     1140

cagagatggc tcagggagaa catctgggag tcgacagagc agctcagaaa atgaactcaa     1200

gtggtctgac caccaaaggg cctggagcag cacagactcc gacagttcca accgcaatct     1260

aaagcccgcc atgaccaaga cggcgagttt tgggggcatc acggtgctga ccaggggtga     1320

cagcacttcc agtactagga gtaccgggaa gctgtccaaa gcaggttccg agtcttccag     1380

cagtgcaggc tcctcaggat cgctgtcccg cacccatcca cctctccaga gcacacccct     1440

agtctcaggt gtggcagctg gctctccagg ctgtgtgcct tatccagaga atggaatagg     1500

gggccaggtt gctcccagca gcaccagcta catcctcctt ccacttgaag ctgcaacagg     1560

catcccgcct ggaagcatcc ttcttaatcc acacacaggc cagccctttg tgaatcccga     1620

tggaactcct gcaatataca acccacccac cagtcagcag cccctgcgaa gcgccatggt     1680

ggggcagtcc caacagcagc caccacagca gcagccctcc ccgcagcccc aacagcaggt     1740

ccagccaccg cagccacaga tggcaggccc tctggtcact cagtctgtcc aggggctgca     1800

ggcttcctcc cagtcagtgc aatatccagc agtctctttt cctccccagc acctcctacc     1860

tgtgtctcca acgcagcact ttcccatgag agatgatgtg gcaacacagt ttggccagat     1920

gaccctgagc cggcagtcct cgggggagac tcctgaaccc ccatcaggtc ctgtctaccc     1980

atcctccctt atgccacagc cggcccagca gcccagctat gtaatcgcct ctacaggcca     2040

gcagcttcct acaggaggat tctcaggctc tggccctccc atctcccagc aggtcctcca     2100

gccccctccc tcaccacagg gatttgtgca acagcctccg cctgcacaga tgcctgtata     2160

ttattaccca tctggtcagt accctacctc aaccacgcaa cagtaccggc ccatggcccc     2220

ggttcagtac aacgctcaga ggagtcaaca gatgccacag gcagcacagc aagcaggtta     2280

ccagccagtc ttgtctggtc aacagggatt ccaaggccta ataggagtgc agcagccacc     2340

tcagagtcag aacgtgataa ataaccaaca aggaactccg gtgcaaagcg tgatggtttc     2400

ctacccaaca atgtcttctt atcaggtgcc aatgacccag ggttctcaag gactgcccca     2460

gcagtcatac caacagccaa tcatgctacc taaccaggca ggtcaagggt cactcccagc     2520

cactggaatg cctgtttact gtaatgtcac accgcccacc cctcagaaca accttaggct     2580

gattggccca cactgcccct ccagcactgt cccagtgatg tcagctagct gcagaacaaa     2640

ctgtgcaagt atgagcaatg ctggttggca ggtcaaattc tgagagctct ggctgtggta     2700

catttcttca gatatttctc atggcctttg atggaagagg aacaaggtgg gaaaactggc     2760

tgaggactta agtattcact caacactcaa atgattgctg ctggtattct gtaaaaaata     2820

aacaaagact aatatacacg ttagctggtt aatggtgcat atttctgtca tgtctgctag     2880

gtatgccttt atagcttagc tagtgacatg aattcatcaa ggtaagattt tctcctacca     2940

ctgaatacca ctgtgtagat tataatatcc ctaatttgga ttagttttgt actttgtgtt     3000

gagtttgtga tgctaaaagt atttaaaaat tatatactaa atcacattgt accaaagctg     3060

taatggaaaa gcaaagaaga attgatgaat tgaaggaata atttatatac attatagagt     3120

tttctttttt aatggatata tactgtattg tagtgtttaa tcaaaataaa actatttgac     3180

ct                                                                    3182


<210> 3375
<211> 2853
<212> DNA
<213> Homo sapiens

<400> 3375
cctccctcca gtctccggat ctccctcggt ccctctctcc tcctcttcct ctctctggac       60

gcccggctcc tccgcacccc ctcccccggg ggtcccgcgg ccttgctccc taccctcacc      120

tcaagacgac catggccacc atcccagact ggaagctaca gctgctagcc cggcgccggc      180

aggaggaggc gtccgttcga ggccgagaga aagcagaacg ggagcgcctg tcccagatgc      240

cagcctggaa acgagggctc ctggagcgcc gccgggccaa gcttgggctg tcccctgggg      300

agcctagccc tgtgctaggg actgtagagg ctggacctcc agacccggat gagtctgcgg      360

tccttctgga ggccatcggg ccagtgcacc agaaccgatt catccggcag gagcggcagc      420

agcagcagca gcaacaacaa cggagtgaag agctgctagc agagagaaag cctgggcctc      480

tggaggcccg ggagcggaga cccagccctg gggagatgcg ggatcagagc cccaagggaa      540

gagagtcaag agaagagaga ctaagtccga gggagaccag agagaggagg ctggggatag      600

ggggagccca agagttgagc ctgaggcctc tggaggctcg ggactggagg caaagcccag      660

gagaggtggg agacaggagc tcccgactgt cagaggcatg gaaatggagg ctgagtcctg      720

gagaaactcc agagcggagt ctgagactag cagagtctcg agagcaaagc cccaggagaa      780

aagaggtgga aagtagactg agcccagggg aatctgccta ccagaagttg ggcctgacag      840

aggcccataa atggagacct gactccagag agtctcagga acagagtttg gtacaactgg      900

aggcaacaga gtggaggctg aggtcaggag aagaaagaca agactactcg gaagaatgtg      960

ggagaaaaga agagtggcca gttccagggg tagctccaaa agagactgca gagctgtccg     1020

agaccctgac aagggaggcc caaggcaaca gttccgcagg agtggaggca gcagagcaga     1080

ggcctgtgga agatggcgag aggggcatga agccaacaga agggtggaaa tggaccctga     1140

actccgggaa ggctcgagaa tggacaccca gggacataga ggctcaaact cagaaaccag     1200

aacctccaga gtcagcagag aagcttctgg aatctcccgg tgtggaggct ggagaagggg     1260

aggctgagaa ggaggaggcg ggggctcagg gcaggcctct gagagccctg cagaactgct     1320

gctctgtgcc ctcccccctc ccaccagagg acgctgggac tggaggcctg agacagcagg     1380

aagaggaagc agtggagctc cagcccccac caccagcccc tctgtctccc ccacccccag     1440

ccccaactgc cccccaacct cctggggatc ccctcatgag ccgcctgttc tatggggtga     1500

aggcagggcc aggggtgggg gccccccgcc gcagtggaca caccttcacc gtcaaccccc     1560

ggcggtctgt gccccctgcg accccagcca ccccaacctc tccagccaca gttgatgctg     1620

cagtcccggg ggctgggaag aagcggtacc caactgccga ggagatcttg gttctggggg     1680

gctacctccg tctcagccgc agctgccttg ccaaggggtc ccccgaaaga caccacaaac     1740

agcttaagat ctccttcagc gagacagccc tggagaccac gtaccaatac ccctccgaga     1800

gttcggtact ggaggagctg ggcccggagc ctgaggtccc cagtgccccc aaccctccag     1860

cagcccaacc cgacgacgaa gaggatgagg aagagctgct gctcctgcag ccagagctcc     1920

agggcgggct gcgcaccaag gccctgattg tggatgagtc ctgccggcgg tgaccatctt     1980

ccaacatagg gatatacctc cctccttctt ataactgaag atcctggagc ccggaagatt     2040

cagggcagac agaccctgat aatgagcctg gcagggaagg gcaaccaaca tcttgtaact     2100

tgctttcccc accctgtttc tgggggcaga gccaattgcc caatttctac cctaatccaa     2160

agtccctggt gtgggtgggg ttaaacgtgc tggtgcatcc taggtcatcc aagagtgagc     2220

gccaagtcct gagaaggggc acagaactcc ctggagggtg gagatggagc acctgccccc     2280

catggcaggg tacactctcc ccacagcctt cctccccacc atcccgtggg gactctcggg     2340

atttaagcac tcgtctctct gggaggccca gaccccactc catttatagg cacatctcct     2400

tcatttccta ggtcactgcc cctttgttta cagctcctgc ctcctccctt gaccacagcc     2460

tggtttacaa attccatcag ctcccagccc cacctgccaa agtcccaggt ttacaagcca     2520

cgcttacttg ctgtgtctgc gtggaattct ctcctctgtc ccctccagtc tcctcattgg     2580

agtgacctga aggtgtggct tcctccactt tttctcagta ttactttgcc ttagttttcc     2640

ccaagaggga aggctggaac tcttaactct gtaccccttg atagttattt aattctgttt     2700

ctcctagtgg ttcacaattg aactgaattg agatggtgtc gggtggctaa ggagacacct     2760

cacctctcct tccccattgt gccgccttta tcaattgcct gttttgtttt gtttgttttt     2820

taactttcca taataaaatg gagttctctt caa                                  2853


<210> 3376
<211> 2233
<212> DNA
<213> Homo sapiens

<400> 3376
cgcaggtccc gcccctctcg tagcctcgcc ccgcccgccg cgcaggcgcc gtccgagggc       60

tccgtttgaa acatggcgcg ggctggccct cggctggtgc tgagcgagga ggcggttcgg      120

gcgaagagcg gcttagggcc tcaccgcgac ctggctgagc ttcagtcatt gtctattcct      180

ggaacttacc aagagaagat cacccacctg ggacattctc tgatgagttt aacaggtctg      240

aaatctttgg atctctcgcg caactccttg gttagtctgg agggcattca gtacctgact      300

gcattggaga gtctcaatct ctactacaac tgcatctcct cgttggcaga agtgtttcgg      360

ctccacgcct taaccgagct cgtggatgtg gacttccggc tgaaccccgt ggtgaaggtt      420

gagcctgact accgcctttt tgttgtgcac ctgctcccca agctccagca gctggacgat      480

cgccccgtga gagcaagcga gcggaaggct tcccgactgc attttgcatc agaggactca      540

ctcgactcca aagagagcgt cccagcttct ttgaaagagg gcagaatcca gacatctgtt      600

gagcccgcag ttggtacagt accagtgtgg ggactctggg aagcagggcc gtgagacgag      660

gaggagcagc tgcagagggt gctgtctgga gaagatgcct tggagccagc tctgtggaga      720

gcttccgcca ctgtacggag cggagccaga ggcctcccgt gcccccaggc cacacacgta      780

cttcacccca cacccagact ccatggatac cgaggactcg gcctcttctc agaagttgga      840

tttgtcagga gaaatggtgc ctggtcccct gccagccccc ggaaagtgca ggaagcgaag      900

aatgcctgtt ggaagattcc agacgttttc ggaccaggag ggtttgggct gcccggagag      960

aactcatggg tcctccgtgc ccaaggagag cctgagcaga caggacagct cagaaagcag     1020

gaacgggagg accttgtctc agcctgaggc ctcggagact gaggagcaga ggtctcgggg     1080

tgtgaccgac accagagagc cgtctcccgg gtcacactcg gctctacccg ggaagaagac     1140

ggccctgcag gcggcgctcc tggagacgct cttggacctg gtggacagga gctggggcgg     1200

ctgcaggtcc ctgcacagca acgaggcatt ccttgctcag gcaagacaca tcttgtcatc     1260

tgttgaagaa ttcacagcag ctcaggacag ctctgcgatg gtgggtgaag atgtcggctc     1320

cctggctctg gagagtaagt ccctgcaaag ccgccttgct gagcagcagc agcagcacgc     1380

ccgggagatg agcgaggtga cggcggagct gcaccacaca cacaaggagc tggatgattt     1440

gagacaacat ttagataaat ctttggaaga gaacagtagg ttaaaatcgc ttttgttgag     1500

tatgaaaaag gaagtgaaga gtgcagacac tgcagccacg ttaaatttgc agatcgctgg     1560

acttcaaaca agtgtgaaga ggctgtgtgg cgagattgtg gaactgaagc agcacctgga     1620

gcactacgac aagatccagg agctcacgca gatgctgcag gagagccaca gctccctggt     1680

cagcaccaat gaacacctgc tgcaggagct gagccaggtg cgggcgcagc acagagccga     1740

ggtggagcag atgcactgga gctaccagga gctcaagaag accatggccc tgtttccaca     1800

cagcagcgcc agccatggag gctgccaggc ctgctgactc ctgccgagaa gctgggccac     1860

cccttaagct tcctggtaaa gttacattgt ctgcaccttt gtacttcttt attgagtgta     1920

ctggctggca agagttctct cttctgttgg taattattta ggatttttgg aatgtattca     1980

ggacctgtag cttggttttc taaagcacct cgtaaaatga tatgattact ccaagccctc     2040

tgcatgtttt cagacagaac acattgacat attttgagac aaactgacta ttaatcttgt     2100

atccagtatc ctgagatgaa gtaaatgcag tgttctactg cctgatgtga aagagagcta     2160

tgtatgataa ttaaagaaaa taattttctg tgtaacaagc aatctttatt taataaacaa     2220

atacattgtt ctg                                                        2233


<210> 3377
<211> 253
<212> DNA
<213> Homo sapiens

<400> 3377
ttctcatctc ctgacactat gtatttcaat tacaaaagtg tgtgtgggag ctgtggattt       60

ggctcttgct atggttgtgg gtatggctgt atacacagca cccactgtgg ctgtaacggt      120

tattatggtt gttatgaaaa taaatattct gttatagatg atctgatatt ttttgcttct      180

aagaaatgcc attgagcatt gtttcttatt tagtttctca aagatctgtt ctgctttaat      240

caccttcaat cct                                                         253


<210> 3378
<211> 1756
<212> DNA
<213> Homo sapiens

<400> 3378
tcttgcggct gttctacccc tccccctccc cgcggtacct tgcacttttc tccctccctg       60

ccccctctcg agtccaccct ccgggccttc tgcccctgat cgcttggttt tccttgcagt      120

cgcctgctgc tgtcgtcggg aggaaagatg aatgggaggg ctgattttcg agagccgaat      180

gcagaggttc caagaccaat tccccacata gggcctgatt acattccaac agaggaagaa      240

aggagagtct tcgcagaatg caatgatgaa agcttctggt tcagatctgt gcctttggct      300

gcaacaagta tgttgattac tcaaggatta attagtaaag gaatactttc aagtcatccc      360

aaatatggtt ccatccctaa acttatactt gcttgtatca tgggatactt tgctggaaaa      420

ctttcttatg tgaaaacttg ccaagagaaa ttcaagaaac ttgaaaattc cccccttgga      480

gaagctttac gatcaggaca agcacgacga tcttcaccac ctgggcacta ttatcaaaag      540

tcaaaatatg actcaagtgt gagtggtcaa tcatcttttg tgacatcccc agcagcagac      600

aacatagaaa tgcttcctca ttatgagcca attccattca gttcttctat gaatgaatct      660

gctcccactg gtattactga tcatattgtc caagtcaaag taaacaagta tggagatact      720

tgggatgagt gaaaaattac atcattggac atgaaggagt ttcaacatcc agcttcatct      780

aggtggtcat gattacctgc atgctttgag ctcagcagca gtcttcataa acacatttaa      840

aacaagatcc tgggtttttg tggtttgact tctatggtgt tttaaaaaaa cacagatttt      900

tagtgttaat attgtgtaaa tgtactcacc ttagggattc atttgaatga tggtattata      960

ccatgattgt atacagtttg tgaaattgtt gcaagggcaa agataactct taaaaaaccg     1020

tcgagattac aatgctctag aatcagcata taagaaaata aatgatatct gcatgttgaa     1080

ttggggtgga tggggggagc aagcataatt tttaagtgtg aagctttgca tcaagaaatt     1140

attaaaaagc tttttttctc cagtattttc tgtattatct taatgtttat ggcaaataaa     1200

atgtaaagga acatgcaaca gccctcatct tccttgattt tatggtttta ttgtttgtaa     1260

tttattgatt tatttttaag ctagttataa tcatgtaggt ataggaaata aagtcatcta     1320

taatatttct ataatatggc tataatatgg ctataaatct ataatatggc tggaggcagt     1380

gggcagtggt tcatgcctgt aatcccagca ctttgggagg ccgaagtggg aggattgcat     1440

gagtccagga gtttgagacc agcctgggca acaaagcgag accctgtctt tacaaaaaaa     1500

taaaaattag ctggcgatgg tgtcgtgtgc ctgtagtcct agttacttaa gaggctgagt     1560

tgggaggatc agttgaaccc agtggttctg ggttgcagtg agctgtggtc acaccactga     1620

actccagcct gtgcgactga gtgagaccct gtgtctaaaa aaataaaaat ataatgaatg     1680

tgatttatgt agataaattg ataatatagt aaataggtaa atgccttaaa aagcattttt     1740

aaagaatttg taaatt                                                     1756


<210> 3379
<211> 5940
<212> DNA
<213> Homo sapiens

<400> 3379
aggacgttgc gtgctcgctc gcgccaggcg agtctccgcg tctccctcgc gaactcggtg       60

aaaggaattg gcgccgttcg acaccaggcg gatccgctct gcagcacgaa cccatctcca      120

gccgcagccg cagccgccgc ccgggccgag gagcagccgc agcagccgcc accagtggcc      180

gagtgagcgg agccgagttt gaggcagcgc ctagcggtga atcggggccc tcaccatgag      240

ttcctcgcct gttaatgtaa aaaagctgaa ggtgtcggag ctgaaagagg agctcaagaa      300

gcgacgcctt tctgacaagg gtctcaaggc cgagctcatg gagcgactcc aggctgcgct      360

ggacgacgag gaggccgggg gccgccccgc catggagccc gggaacggca gcctagacct      420

gggcggggat tccgctgggc gctcgggagc aggcctcgag caggaggccg cggccggcgg      480

cgatgaagag gaggaggaag aggaagagga ggaggaagga atctccgctc tggacggcga      540

ccagatggag ctaggagagg agaacggggc cgcgggggcg gccgactcgg gcccgatgga      600

ggaggaggag gccgcctcgg aagacgagaa cggcgacgat cagggtttcc aggaagggga      660

agatgagctc ggggacgaag aggaaggcgc gggcgacgag aacgggcacg gggagcagca      720

gcctcaaccg ccggcgacgc agcagcaaca gccccaacag cagcgcgggg ccgccaagga      780

ggccgcgggg aagagcagcg gccccacctc gctgttcgcg gtgacggtgg cgccgcccgg      840

ggcgaggcag ggccagcagc aggcgggagg ggacggcaaa acagaacaga aaggcggaga      900

taaaaagagg ggtgttaaaa gaccacgaga agatcatggc cgtggatatt ttgagtacat      960

tgaagagaac aagtatagca gagccaaatc tcctcagcca cctgttgaag aagaagatga     1020

acacttcgat gacacagtgg tttgtcttga tacttataat tgtgatctac attttaaaat     1080

atcaagagat cgtctcagtg cttcttccct tacaatggag agttttgctt ttctttgggc     1140

tggaggaaga gcatcctatg gtgtgtcaaa aggcaaagtg tgttttgaga tgaaggttac     1200

agagaagatc ccagtaaggc atttatatac aaaagatatt gacatacatg aagttcgtat     1260

tggctggtca ctaactacaa gtggaatgtt acttggtgaa gaagaatttt cttatgggta     1320

ttctctaaaa ggaataaaaa catgcaactg tgagactgaa gattatggag aaaagtttga     1380

tgaaaatgat gtgattacat gttttgctaa ctttgaaagt gatgaagtag aactctcgta     1440

tgctaagaat ggacaagatc ttggcgttgc cttcaaaatc agtaaggaag ttcttgctgg     1500

acggccactg ttcccgcatg ttctctgcca caactgtgca gttgaattta attttggtca     1560

gaaggaaaag ccatattttc caatacctga agagtatact ttcatccaga acgtcccctt     1620

agaggatcga gttagaggac caaaggggcc tgaagagaag aaagattgtg aagttgtgat     1680

gatgattggc ttgccaggag ctggaaaaac tacctgggtt actaaacatg cagcagaaaa     1740

tccagggaaa tataacattc ttggcacaaa tactattatg gataagatga tggtggcagg     1800

ttttaagaag caaatggcag atactggaaa actgaacaca ctgttgcaga gagcccccca     1860

gtgtcttggg aaatttattg agattgctgc ccgaaagaag cgaaatttta ttctggatca     1920

gacaaatgtg tctgctgctg cccagaggag aaaaatgtgc ctgtttgcag gcttccagcg     1980

aaaagctgtt gtagtttgcc caaaagatga agactataag caaagaacac agaagaaagc     2040

agaagtagag gggaaagacc taccagaaca tgcggtcctc aaaatgaaag gaaactttac     2100

cctcccagag gtagctgagt gctttgatga aataacctat gttgaacttc agaaggaaga     2160

agcccaaaaa ctcttggagc aatataagga agaaagcaaa aaggctcttc caccagaaaa     2220

gaaacagaac actggctcaa agaaaagcaa taaaaataag agtggcaaga accagtttaa     2280

cagaggtggt ggccatagag gacgtggagg attcaatatg cgtggtggaa atttcagagg     2340

aggagcccct gggaatcgtg gcggatataa taggaggggc aacatgccac agagaggtgg     2400

tggcggtgga ggaagtggtg gaatcggcta tccataccct cgtgcccctg tttttcctgg     2460

ccgtggtagt tactcaaaca gagggaacta caacagaggt ggaatgccca acagagggaa     2520

ctacaaccag aacttcagag gacgaggaaa caatcgtggc tacaaaaatc aatctcaggg     2580

ctacaaccag tggcagcagg gtcaattctg gggtcagaag ccatggagtc agcattatca     2640

ccaaggatat tattgaatac ccaaataaaa cgaactgata catatttctc caaaaccttc     2700

acaagaagtc gactgttttc tttagtaggc taacttttta aacattccac aagaggaagt     2760

gcctgcgggt tcctttttta gaagctttgt gggttgattt tttttctttt cttttttgta     2820

catttttaat tgcagtttaa aagtgaatcg taagagaacc tcagcattgt gcacgataag     2880

agaatgtgtc agtatttcag ggttctacat tttatctgta aaatgtgact tttttttttt     2940

tttatcacaa cagaagtaaa atgttgcttt gtacctggtg tcttttatta agaatttact     3000

ccccccattt ctcacagaga ataacagtcg ggagtcattg tcacaatata atagaaatgt     3060

tagcaaccag attcatgtaa ggactaagtg gtcctcatga attgcattaa gactctgtac     3120

tgctcatatt acactccatc ctctctgtag tttgctgggt agtggagggg gtaagctaaa     3180

tcatagtttc tgacaataac tgggaaggtt ttttcttaaa ataacaatgg aattggtata     3240

attgggattg aaaactaaaa cttggaacta agatagagaa gatggagtgt atgtagaagg     3300

gctgttaaaa atgtaaaact tggttgcatt atttgtggag gctcaaactt gtgaaggtta     3360

ataccataat ttttccattt gttctgcatt ttgattctga aaagaaagct ggctttgccc     3420

atttcttatt aaaaaaactt gttgtaaatc cagttgtcta atgggatcta tatgaagtta     3480

gccatgtctg tatgcccttc tcccacaaaa tactgtataa ctagtgtgct tgtagtagtt     3540

aactccacca tctttgtaag ctaatgaaat tgtgagtcac ccatttatat cttaattttt     3600

aatcatgtca gttcttgaat gggtatctcc ttagcctgct gatttctttt tctttctaaa     3660

gaaagtgggt ggagaaatta atttagacgt ttgtttgcaa taaaaagaat tcattttact     3720

cttgttttgg gattctcgcc atcaaggttc aaaatccctt tatataactc ccaagaggag     3780

aaatttatta agtgtgtgct ttctggacag cttattcttt actctgcata gaacatttag     3840

gttttaaaaa cttaaatgta tactgacaat tgatacataa ttatgaagta aagttgaatt     3900

cttcccttcc cctccccccc agacaacttt taacatattt aatgagggga aaaggtactg     3960

gctgggagaa gttaacactg agtttatcat ctttacagaa tgctaatgct gtcctcaact     4020

gattatttta tatacatata tatgatacat gaaactctgg gatcagatgc ttttagaagc     4080

catcatgcaa gccagtcatt gatgtcactg ctacacaaca ctgctaactt gactgtagct     4140

atgtaataac attagatccc ctaattgtaa ttatattggg tttgcacaga acactttaat     4200

cttcccctca ccaatgtgaa gtgaggaatc aggagtcaaa ctgtagaact aaaatttgac     4260

ttcagtctag cgtttccttg gtgtttttag gttgctttgg taagtttagg tttgctatat     4320

ttctgattgc ttagaatttt gttttagccc tttaaaatca gatcataaat atgaattcat     4380

acttctaagg aattttcttg ctataagctg gagtttaggt gatgtatagg ttcagttgag     4440

acatttttgg aacaggcaaa tccttagtta acataagata tttaacagtt gaagatagtg     4500

tcatggattt ttatcttttt tagcaagtaa tgctaagaac cactggcctg agctactact     4560

cttcagtata cattattagg attgcataga cttactagag gaacagtttc aggttttgat     4620

gctaatcagt gttgtgtcct aaagttgtcc tttgtgcctt taaaaagttt tggatatatc     4680

ttctagttta aaattgctta ttaaggaatt cattttataa ttgcagtggg aaagtaatgg     4740

tcaagtaaca ctaggtagac tatcatgcct gtttagccca gagaatttgg ggggagagag     4800

aatagataaa aatggcaccc agaaaaatgt taaaatcttt agtcaagact agaattaata     4860

caattgtcta cacttgtatg gcagaaataa ccttataaag tgtttaagga attcagagaa     4920

gggaatgtac caaataagca acagggagaa aattaggtaa gaagtaagat acgaacgaga     4980

aacctgattt attgctcatc cttcccttgc ctccctaatg gcaagcaaaa ctctgaacat     5040

ctgaaaagga tgtagttctg gacaaatcct gactacccag aggaaactca ctgtgagatt     5100

gctgttgatt tgaagggtgc tttcactaag gttatatttt aaagtagaat aacacatgct     5160

gagtgtaaac tggctttgga ttggtcagct gcagtagtac aaaaacagca tagaatttga     5220

gaaaactaaa actgctatga gatagctatg agaaaactaa aactgctatg agatagaaat     5280

gatgtaaaat tatgtggaaa gttttccctc atatactcac atacagcctt tgaagggctc     5340

tggctctgac cggttgatgg ccttgagcga gatgaaatca tgaaattgag tcaaatcaat     5400

ttgacattga aatgacaaga ggaaactctt aaatacataa aaacaagctc tcatttgcct     5460

aggatagata ctgtcttaaa aataaagact gaacctagat gttctgagca ctagcaacaa     5520

ggtattttaa caagtttaaa ggaattctct gaaaaagtta taaaattatt ctaggaaaca     5580

taaccataat agtgttttaa gggactttca cctggggatt ttatattcat gaacagagtg     5640

tattctgtat ttaaaatgtc tcatttgtgg gaattggatg acatgttttt tgataaattt     5700

attcacaata taaattgact ttttattcta ggaccatgtg aataatgggt tccattgcac     5760

aaatacaaat attttaatag cttcttaggc agtggtgtag acatcttgga tataaataat     5820

tgtagatctt gtatatttga tttttaaaaa actagaataa acagagaggc ataaacatat     5880

cttagagtcc aagtggtagt gtttagcatt ggatataata aatggatgtt ttacaaagtg     5940


<210> 3380
<211> 2758
<212> DNA
<213> Homo sapiens

<400> 3380
gagcgaggag ccgggagcgg ggaacaggga gtcggggagc cgggaaccag ggctggcagc       60

ggccgccatg agcacggtgg accttgctcg cgtgggcgcg tgcatcctga agcatgcggt      120

gaccggggag gccgtggagc tgcggagcct gtggcgggag cacgcgtgcg tggtggccgg      180

gctgcggcgc ttcgggtgcg tggtgtgccg ctggatcgcc caggacctca gcagccttgc      240

tgggctcctg gaccaacacg gcgtgcgcct ggtgggcgta gggcccgagg ccctgggtct      300

gcaggagttc ctggacggcg actacttcgc gggagagctc tacctggatg agagcaagca      360

gctttacaag gagctaggct tcaagcggct ctggacccag gcttctccgg agtttggcca      420

agcgacctgg tgtcttcgca ggtacaacag cctgagcatc ctcccagcag ctctggggaa      480

gcccgtgcgt gatgtggctg ccaaggccaa ggctgttggc atccagggga acttgtctgg      540

ggacctgctg cagagcggag ggctgctggt ggtcagcaaa ggtggtgata aagtgctcct      600

gcatttcgtc cagaagtccc caggcgacta cgtccccaag gagcacatcc tgcaggtcct      660

gggcatctct gcggaggtct gtgccagcga cccgcctcag tgtgacagag aggtgtgagg      720

gaggcgaagg ccctggcctc cgaggatctg ggtggcgtct gctgccctag gtgtgctgga      780

agtccacttg gaagaactgt tccggaggcg ctgggtcggg atgccgaacc tctcctgatc      840

cgccggcagc aacgagccat taaaactgca gttcctgacc acgcactgct tcgcaggctc      900

cgagccctgc atcctccaca gcccccgcct tgctcactgt tgggccctca gggcgggcag      960

ggtggctgtg agtcccaggt gtcatcttcc tgctctgcga ctttctctgg agaccttggg     1020

cctttggcct gtggggcact ggggatggta acctcactgc cccgtcactc ccttcaaagg     1080

cgacagaccc aagcccacgt caggagagga gcgtggggtc agctccagca gggtcggggt     1140

cagtgcctgt gtctggtggg ggccactcag gagagttggg ttttcagggc agagatgggc     1200

ttgattccac ctggtggggt gggtggaccc tggagactct caggtgatgg gccagcctgc     1260

cccaaggctc tttactgatg tcagaatcat tgtttgcacc tgctgggtat ggcctttggg     1320

gcggccggcc cgggagggtc ttagtctaat taggtgtgtc cagcttcttg gccacctttc     1380

cctggggacc ctaacaggcc cagagcagag ccccttacct cccaggtcag actacctgct     1440

caggccctcc cctcccatgc aggccgatga caactgcagc cctctctgca ctccctagtc     1500

cagacctggg gaccactgtg ggttcctgtg ggtctcccgg ctcccttcct gcccccaatg     1560

ccacccttgc agtggccatt taaaaatgca tagcaggtga cccactgcgt ccctttgcgt     1620

tcagcccctc ctctggcttt cagttacacc aagctaaaat ttcaggttcc cagctgcagc     1680

tctctgggtc ccccggtgcc ccagtggggc tccccgcatc tgaatgtgtg gtccctgggg     1740

gtgggcactt gggggcatcc tggtcactgc tggccctagc attggaccct aggagacctg     1800

actggaactg gctccctccc catcagctcc cagctgtcac tctctcccac ccccgggcag     1860

ctgttttgcc caagaccact gctacctgtt tacccaccct ggtccctccc agacaagcaa     1920

ggcctctgat ttctttgaag catttactta gctcaagtct gaagctgtag atactggaag     1980

acaatgcacc ttggagggtg ggcaggacac agttgattgt ctctacagag ctgtgacggg     2040

ggcactgagc cccgcgggtg tctgtggagg gggctccggt ccaggtactg cactggacac     2100

tgctcatccc tgggtgtcag gcaggtggct gcaccctagg ccaggcgcag aggcctggca     2160

ggcaggcttg gcatggttgg ccggggcggg acgtacactg ggtcgccgct agctgcacct     2220

tcgcacagat gcctccgagc agcgggtggg cgtgggccgc acagcgcggc agggccttgg     2280

ctaccacacg cggcatcgct ccttggggtg catgggggtg ccccgggcac agtggaacgt     2340

gtctgcgaag gcggccaggt tctgcagcga ccccagtacc ctgtgggtgg gtgggtgtga     2400

cagcaggagc attgccatct tggacaaaca tggccatttt aagttctccg tgattaaaaa     2460

ccagcccaaa acatcagcct aatggctcat gtcagtatga gcagaaacat ttcaaccatg     2520

agataaaccc ccatctgacc agaaacatgc caatcctgag aataacctcc cctccagcca     2580

gagatattcc aactctgcaa taaaactctc cttcacacag aaacattcgc agcctgcggt     2640

aggctccccc ttcctaaacc cttaaatgcc cttagtctgt aagagaatgt ccctgaccga     2700

aatcggccag aagcccctct caggtttatt cccaaaataa acctgtctct gttgagcc       2758


<210> 3381
<211> 2506
<212> DNA
<213> Homo sapiens

<400> 3381
gagccgggcg tcggaggccc tgaggccggc cgcagagccc ggagattgag cggctttggg       60

gaaggggtgg ttaaggaagt aggcctcggc ttccgtcggt cgctgctcgg ctctgcggcc      120

cgtttggacc gcggaggagg tcgccttccc ctcccgtggg gcgctcggtt ggactgtgga      180

aaccggggca acttcccccg tcttcccggc tgaggcgcct gcgtgggcct cgcgacccgg      240

ctcgccaacc cgcctcggcc cgcacgccca cctcgcctgc ggaccccgga ggtgcctacg      300

cggactagtg acgccccccg cccgtcggca actccacccg gcgctgaccc cctcaactct      360

gcaggacccg gcgcgcgagg accccacgac ccgcgggcgc ctgcgcggac cccgcgagcc      420

ccggcgcctg cgcgagtccc cgacgccgcc cccgccccca ctcaccgggc cccgcagcag      480

gggccggagc cgccggcggc ggggcggggg ggggcgcccc gatgagcccc gagtgcgagg      540

agccgccgcc ccccctcgca gggcgccatg ttttggaagt ttgacctgca cacaagctcg      600

cacctggaca cgctgctgga gcgggaggac ctgagcctgc ccgagctgct ggacgaggaa      660

gacgtgctgc aggagtgcaa ggtcgtcaac cgcaagctgc tggacttcct gctgcagcca      720

ccccacctgc aagcaatggt ggcctgggtc acccaggagc cgccagatag cggtgaggag      780

cggctgcgct acaagtaccc cagtgtggcc tgcgagattc tgacctcaga tgtgccccag      840

atcaatgatg ccctgggtgc tgatgagtcc cttctgaacc ggctctacgg cttcctgcag      900

agcaccggca gcctcaaccc actgctggcc agcttcttca gcaaggtcat gggcatcctc      960

atcaaccgca agacagacca gctcgtgtcc tttcttcgga agaaggatga cttcgtggac     1020

ctgctgctgc agcacattgg cacctcggcc atcatggacc tcctgctgcg cctgctcacc     1080

tgtgtggagc ggcctcagct gaggcaggat gttgtcaatt ggctcaacga ggagaagatc     1140

gtccagcggc tgattgagca gatccacccg tcgaaggatg agaatcaaca ttccaacgca     1200

tcccagtccc tgtgtgacat catccgcctg agccgggagc agatgatcca agtccaggac     1260

agcccagtgc ctacagatgc cccgaccagc ccccgagtct ccggggagga agagctgcac     1320

actgggcctc cagccccaca ggggcccctc agtgtgcccc agggcctccc cactcagagc     1380

ctggccagcc ctcctgcccg tgacgccctg cagctcaggt ctcaggaccc cacacccccc     1440

tcagcacctc aggaagccac agaaggcagc aaagtcacgg agccctcagc cccttgccag     1500

gccttggtta gcatcgggga ccttcaggcc accttccacg ggatccgttc tgcccccagc     1560

tcctcggaca gtgcaaccag agacccctct acctctgtcc cagcctccgg ggcccaccag     1620

cccccccaga ccacagaagg ggagaagagc ccagagccct tggggcttcc ccaaagccag     1680

agtgcccagg ccctcacgcc tcctccgata cccaatggct ctgccccgga agggcctgca     1740

tccccaggct cccaatagct gcctggtgcg gcagcggcgg ccaaatcttc cgtcctcccg     1800

tggatctccc ggggtggggg cagggcgggt cccacgatgg cccccattgc cctcatcacc     1860

ctgacacccc cacattctct cctctggacc cccaggaggc tggtgccagg gagacaggcc     1920

caacccaccc ccatttgcac tgagaagaga agttttggag cgttgcctcc tagaataaag     1980

atacagagag tcaaatagag agaatggaga gagagaaaca tatattatat attatataga     2040

gagagggagg agagcgagag agagtgagga caccgaactg ggctggcggc tccaaagcac     2100

agccttccct gttccgtccc agcgggagct ggtgttaggg gtcccaaggt tgccacccac     2160

gtgcccagct gtcccacgct gcagcgcaga cggccacgcc cacacccggc cttttagctc     2220

aggtccacca tgggggacgg cccagcgtgg gtgggggtgc cagagggtcc cgagtggggg     2280

ccgtgccttt gcccagaccc tgcactttca accaggccag tccggctctg gggagcaggg     2340

gcctccccgg caacagcccc aggggccttg agggtctgag gtcccagccc tgttgccaag     2400

tgaccttgtc cccagctccc tcctcccagg ctggtgtgag tgtgcgtgcg tttgtgccga     2460

gcttctattt catattgcaa atataaataa aggaaggcag tttacg                    2506


<210> 3382
<211> 2791
<212> DNA
<213> Homo sapiens

<400> 3382
gcggccgccg tagttgaatc tcctcggcgc cggaagcccc gccactccgc ttcctggttc       60

atgtgcggcc ttcgttccct cgctatctcg accttgactt cgcatgtgca tccgccgaag      120

tctttctaga tcaatcggcc ccatctctcg tcttcccgat tcggccatga cctcacccgt      180

atcctcgacg taggacctcg gacttcattt ccgccacccc gacacttccg gaatccccgg      240

aagcgacccg ttgccatggc gactatgtac acagccaggc agccccgcgt ggggagtgca      300

ggtggtttcg gttgcggcag tcgcgtcccg ggagcgtcgc tgcctggtga acgctagaat      360

gggtactagg aaaaaagttc atgcatttgt ccgtgtcaaa cccaccgatg actttgctca      420

tgaaatgatc agatacggag atgacaaaag aagcattgat attcacttaa aaaaagacat      480

tcggagagga gttgtcaata accaacagac agactggtcg tttaagttgg atggagttct      540

tcacgatgcc tcccaggact tggtttatga gacagttgca aaggatgtgg tttctcaggc      600

cctcgatggc tataatggca ccatcatgtg ttatgggcag acgggagctg gcaagacata      660

caccatgatg ggggcaactg agaattacaa gcaccggggg atcctccctc gtgccctgca      720

gcaggttttt aggatgatcg aagaacgccc cacacatgcc atcactgtgc gtgtttccta      780

cttggaaatc tataatgaga gcctgtttga tctcctgtcc actctgccct atgttggacc      840

ctcagtcaca ccaatgacca tcgtggaaaa ccctcaagga gtcttcatta agggcttgtc      900

agttcacctc acaagtcagg aggaggatgc attcagcctc ctttttgagg gtgagaccaa      960

caggattata gcctcccaca ctatgaacaa aaactcttcc agatcacact gcattttcac     1020

catctactta gaggcccatt cccggacctt atcagaggaa aagtacatca cttccaaaat     1080

taacttggtg gatctggcag gctcagagag gctggggaag tctgggtctg agggccaagt     1140

cctgaaggaa gccacctaca tcaacaaatc gctctcattc ctggagcagg ccatcattgc     1200

ccttggggac cagaagcggg accacatccc ctttcggcag tgcaagctca cccacgctct     1260

gaaggactcg ttagggggaa actgcaatat ggtcctcgtg acaaacatct atggagaagc     1320

tgcccagtta gaagaaacgc tatcttcact gagatttgcc agcaggatga agctagtcac     1380

cactgagcct gccatcaatg aaaagtatga tgctgagaga atggtcaaga acctggagaa     1440

ggaactagca ctactcaagc aggagctggc tatccatgac agcctgacca accgcacctt     1500

tgtgacctat gaccccatgg atgaaatcca gattgctgag atcaactccc aggtgcggag     1560

gtacctggag gggacactgg acgagatcga cataatcagc cttagacaga tcaaggaggt     1620

gttcaaccag ttccgggtgg ttctgagcca acaggaacag gaagtggagt ccactttgcg     1680

caggaagtac accctcattg acaggaatga ctttgcagcc atttctgcta tccagaaggc     1740

ggggcttgtg gatgttgatg gccacctagt gggtgagcct gaaggacaaa actttggact     1800

cggagtcgcc cctttctcta ccaaacctgg gaagaaagcc aagtccaaga agacattcaa     1860

agagccactc aggcccgaca ccccaccctc caaaccagtg gcctttgagg agtttaagaa     1920

tgagcaaggt agtgagatca accgaatttt caaagaaaac aaatccatct tgaatgaacg     1980

gaggaaaagg gccagcgaga ccacacagca catcaatgcc atcaagcggg agattgatgt     2040

gaccaaggag gccctgaatt tccagaagtc actacgggag aagcaaggca agtacgaaaa     2100

caaggggctg atgatcatcg atgaggaaga attcctgctg atcctcaagc tcaaagacct     2160

caagaagcag taccgcagcg agtaccagga cctgcgtgac ctcagggctg agatccagta     2220

ttgccagcac ctagtggatc agtgtcgcca ccgcctgctc atggaatttg acatctggta     2280

caatgagtcc tttgtcatcc ctgaggacat gcagatggca ctgaagccag gcggcagcat     2340

ccggccaggc atggtccctg tgaacaggat tgtgtctctg ggagaagatg accaggacaa     2400

attcagccag ctgcagcaga gggtgcttcc tgagggccct gattccatct ccttctacaa     2460

tgccaaagtc aagatagagc agaagcataa ttacttgaaa accatgatgg gcctccagca     2520

ggcacataga aaatagaacc tcatcgccag taccttaaag gacaagacca gcaactccca     2580

cctactgtag tggagctgct caaccacctg cccagagctg cagccccctc tactccaatg     2640

ctgggaccca gcacagagaa cacatttggc ctgcatgttg ggaggagcat cctccaagga     2700

caaccttgct catctccaca gagcactttg ggttttaatt cactgtctta tatgcaggga     2760

caggataaaa taactttcta gtttggactt t                                    2791


<210> 3383
<211> 565
<212> DNA
<213> Homo sapiens

<400> 3383
agctgtggtt gccggaagtt gagcggcggc ttctcaaacc ccataatgct ggtatccagt       60

gcatccgttc tcaaaaactg aagctgatgg acaccagatt gcatgtgaag gtgaaggata      120

ttatagcaga aggaaaccaa aataaaagaa aaacagctcc tggaagtaac caatgagaag      180

gacagataag agtttgaaga ctgtggatgt gactgcttgt tccctggttg acacactgaa      240

gaagaaatca tgttgattca gagttggctt ggaggcaaga aataatggcg gcagctacgg      300

gggatcctgg actctctaaa ctgcagtttg ccccttttag tagtgccttg gatgttgggt      360

tttggcatga gttgacccag aagaagctga acgagtatcg gctggatgaa gctcccaagg      420

acattaaggg ttattactac aatggtgact ctgctgggct gccagctcgc ttaacattgg      480

agttcagtgc ttttgacatg agtgctccca ccccagcccg ttgctgccca gctattggaa      540

cactgtataa caccaacaca ctcga                                            565


<210> 3384
<211> 544
<212> DNA
<213> Homo sapiens

<400> 3384
gccgcccttg catcctgatg ggtccttaca gtggggaggc tgtaagaata attcaagttt       60

tccatctgga aagcatttgc ttcgcaaaca gccacagctt acagactaca agcagtttag      120

aaacaagact accacctgaa tatactacac atgccttcac ctgccttttg atgattgcag      180

cgtcaccctt tacaccagaa agctggcggg cactatgggg aaaaaacaaa acaagaagaa      240

agtggaggag gtgctagaag aggaggaaga ggaatatgtg gtggaaaaag ttctcgaccg      300

tcgagtggta aagggcaaag tggagtacct cctaaagtgg aagggattct cagatgagga      360

caacacatgg gagccagaag agaacctgga ttgccccgac ctcattgctg agtttctgca      420

gtcacagaaa acagcacatg agacagataa atcagaggga ggcaagcgca aagctgattc      480

tgattctgaa gataagggag aggagagcaa accaaagaag aagaaagaag agtcagaaaa      540

gcca                                                                   544


<210> 3385
<211> 760
<212> DNA
<213> Homo sapiens

<400> 3385
tggcgatctg ggcaaggcat tttcatccct ttgcagacaa ccccggctgc tgttaatgct       60

gaaaatagct caaatgctct cagaacagta gcaccaccca gcagctggga ttctttccct      120

ctctcatttg cctctctctt gctttttttc cttcagacac ttggattgga cttaatctta      180

aacctctgga gttcaagacc ttttaaaaag ggctaaataa acaatctcta catgtaaaag      240

gccactgact cctacttcct ctgtatagag caactgttga actcagctgc ctgtagggcg      300

tgattctcag tcaccagact cagcttggag atcttacaat gatggcaatc aggagacact      360

gaacggagat gctacatatt cctctcttgc agcaaaaggt tttagaagcg ttcgaccaaa      420

cctacaagat aaaagatcac caactcagag ccagataaca gtgaatggaa actcaggagg      480

tgccgtgagt cccatgagtt actatcagag gccgttttcc ccctcggcat attctctccc      540

agcctcactc aactccagca ttgtcatgca gcacggcaca tccctcgatt ccacagacac      600

atatccccag catgcgcagt ctctggatgg caccaccagc agctctatcc ccctgtaccg      660

atcctcagag gaagagaaga gagtgacagt catcaaagcc ccgcattacc cagggatcgg      720

gcccgtggat gaatccggaa tccccacagc aattagaacg                            760


<210> 3386
<211> 1692
<212> DNA
<213> Homo sapiens

<400> 3386
gtgaggctgc ggaccgggag cagcggccgc aggcgccatg gctgcggagc ggacccggcc       60

gctgcaaggc tctggcggtc cgagcgtgcc tagtagctgt gaacccggcg cgaggtcccg      120

ggccccgggg cgctcgctca ggtcagtgcc gcgcggaaca cgattccgag agcaagggac      180

ctgggagcaa cgaatgggtt gatgggatct ggattttaga gacgggaaaa cagggttttg      240

gagttactgc ctcctactgc ctccatttcc ttagctgcga aatgagttaa cagtgatgtc      300

ccagggctac caaacgtttg aaagacgatg aagtgtgatg aggtggttta tgaagtacaa      360

agcgctatac tgcgccataa ttgtgggtat gccatgaaaa caggtaaatt tttccataac      420

cttatggaga gaaaggactt tgagacatgg cttgataaca tttctgttac atttctttct      480

ctgacggact tgcagaaaaa tgaaactctg gatcacctga ttagtctgag tggggcagtc      540

cagctcaggc atctctccaa taacctagag actctcctca agcgggactt cctcaaactc      600

cttcccctgg agctcagttt ttatttgtta aaatggctcg atcctcagac tttactcaca      660

tgctgcctcg tctctaaaca gtggaataag gtgataagtg cctgtacaga ggtgtggcag      720

actgcatgta aaaatttggg ctggcagata gatgattctg ttcaggacgc tttgcactgg      780

aagaaggttt atttgaaggc tattttgaga atgaagcaac tggaggacca tgaagccttt      840

gaaacctcgt cattaattgg acacagtgcc agagtgtatg cactttacta caaagatgga      900

cttctctgta cagggtcaga tgacttgtct gcaaagctgt gggatgtgag cacagggcag      960

tgcgtttatg gcatccagac ccacacttgt gcagcggtga agtttgatga acagaagctt     1020

gtgacaggct cctttgacaa cactgtggct tgctgggaat ggagttccgg agccaggacc     1080

cagcactttc gggggcacac gggggcggta tttagcgtgg actacaatga tgaactggat     1140

atcttggtga gcggctctgc agacttcact gtgaaagtat gggctttatc tgctgggaca     1200

tgcctgaaca cactcaccgg gcacacggaa tgggtcacca aggtagtttt gcagaagtgc     1260

aaagtcaagt ctctcttgca cagtcctgga gactacatcc tcttaagtgc agacaaatat     1320

gagattaaga tttggccaat tgggagagaa atcaactgta agtgcttaaa gacattgtct     1380

gtctctgagg atagaagtat ctgcctgcag ccaagacttc attttgatgg caaatacatt     1440

gtctgtagtt cagcacttgg tctctaccag tgggactttg ccagttatga tattctcagg     1500

gtcatcaaga ctcctgagat agcaaacttg gccttgcttg gctttggaga tatctttgcc     1560

ctgctgtttg acaaccgcta cctgtacatc atggacttgc ggacagagag cctgattagt     1620

cgctggcctc tgccagagta caggaaatca aagagaggct caagcttcct ggcaggcgaa     1680

catcctggct ga                                                         1692


<210> 3387
<211> 2863
<212> DNA
<213> Homo sapiens

<400> 3387
gttcgcgcct ggggctgtgg tcttcccgcg cctgaggcgg cggcggcagg agctgagggg       60

agttgtaggg aactgagggg agctgctgtg tcccccgcct cctcctcccc atttccgcgc      120

tcccgggacc atgtccgcgc tggcgggtga agatgtctgg aggtgtccag gctgtgggga      180

ccacattgct ccaagccaga tatggtacag gactgtcaac gaaacctggc acggctcttg      240

cttccggcgc agtaacagta tctccaagtc ccctggcccc agctccccaa aggagcccct      300

gctgttcagc cgtgacatca gccgctcaga atcccttcgt tgttccagca gctattcaca      360

gcagatcttc cggccctgtg acctaatcca tggggaggtc ctggggaagg gcttctttgg      420

gcaggctatc aaggtgacac acaaagccac gggcaaagtg atggtcatga aagagttaat      480

tcgatgtgat gaggagaccc agaaaacttt tctgactgag gtgaaagtga tgcgcagcct      540

ggaccacccc aatgtgctca agttcattgg tgtgctgtac aaggataaga agctgaacct      600

cctgacagag tacattgagg ggggcacact gaaggacttt ctgcgcagta tggatccgtt      660

cccctggcag cagaaggtca ggtttgccaa aggaatcgcc tccggaatgg cctatttgca      720

ctctatgtgc atcatccacc gggatctgaa ctcgcacaac tgcctcatca agttggacaa      780

gactgtggtg gtggcagact ttgggctgtc acggctcata gtggaagaga ggaaaagggc      840

ccccatggag aaggccacca ccaagaaacg caccttgcgc aagaacgacc gcaagaagcg      900

ctacacggtg gtgggaaacc cctactggat ggcccctgag atgctgaacg gaaagagcta      960

tgatgagacg gtggatatct tctcctttgg gatcgttctc tgtgagatca ttgggcaggt     1020

gtatgcagat cctgactgcc ttccccgaac actggacttt ggcctcaacg tgaagctttt     1080

ctgggagaag tttgttccca cagattgtcc cccggccttc ttcccgctgg ccgccatctg     1140

ctgcagactg gagcctgaga gcagaccagc attctcgaaa ttggaggact cctttgaggc     1200

cctctccctg tacctggggg agctgggcat cccgctgcct gcagagctgg aggagttgga     1260

ccacactgtg agcatgcagt acggcctgac ccgggactca cctccctagc cctggcccag     1320

ccccctgcag gggggtgttc tacagccagc attgcccctc tgtgccccat tcctgctgtg     1380

agcagggccg tccgggcttc ctgtggattg gcggaatgtt tagaagcaga acaagccatt     1440

cctattacct ccccaggagg caagtgggcg cagcaccagg gaaatgtatc tccacaggtt     1500

ctggggccta gttactgtct gtaaatccac caggaactcc ctggcagtgg attgtgggag     1560

gctcttgctt acactaatca gcgtgacctg gacctgctgg gcaggatccc agggtgaacc     1620

tgcctgtgaa ctctgaagtc actagtccag ctgggtgcag gaggacttca agtgtgtgga     1680

cgaaagaaag actgatggct caaagggtgt gaaaaagtca gtgatgctcc ccctttctac     1740

tccagatcct gtccttcctg gagcaaggtt gagggagtag gttttgaaga gtcccttaat     1800

atgtggtgga acaggccagg agttagagaa agggctggct tctgtttacc tgctcactgg     1860

ctctagccag cccagggacc acatcaatgt gagaggaagc ctccacctca tgttttcaaa     1920

cttaatactg gagactggct gagaacttac ggacaacatc ctttctgtct gaaacaaaca     1980

gtcacaagca aaggaagagg ctgggggact agaaagaggc cctgccctct agaaagctca     2040

gatcttggct tctgttactc atactcgggt gggctcctta gtcagatgcc taaaacattt     2100

tgcctaaagc tcgatgggtt ctggaggaca gtgtggcttg tcacaggcct agagtctgag     2160

ggaggggagt gggagtctca gcaatctctt ggtcttggct tcatggcaac cactgctcac     2220

ccttcaacat gcctggttta ggcagcagct tgggctggga agaggtggtg gcagagtctc     2280

aaagctgaga tgctgagaga gatagctccc tgagctgggc catctgactt ctacctccca     2340

tgtttgctct cccaactcat tagctcctgg gcagcatcct cctgagccac atgtgcaggt     2400

actggaaaac ctccatcttg gctcccagag ctctaggaac tcttcatcac aactagattt     2460

gcctcttcta agtgtctatg agcttgcacc atatttaata aattgggaat gggtttgggg     2520

tattaatgca atgtgtggtg gttgtattgg agcaggggga attgataaag gagagtggtt     2580

gctgttaata ttatcttatc tattgggtgg tatgtgaaat attgtacata gacctgatga     2640

gttgtgggac cagatgtcat ctctggtcag agtttacttg ctatatagac tgtacttatg     2700

tgtgaagttt gcaagcttgc tttagggctg agccctggac tcccagcagc agcacagttc     2760

agcattgtgt ggctggttgt ttcctggctg tccccagcaa gtgtaggagt ggtgggcctg     2820

aactgggcca ttgatcagac taaataaatt aagcagttaa cat                       2863


<210> 3388
<211> 682
<212> DNA
<213> Homo sapiens

<400> 3388
ggaaacctgt tgagatcaca gagaatatac tgacggcata aaagggcaga accatagcag       60

ggtgcgcctc gcagtcacct ctgtgccctg ctggttgtct tcccagcgct gctgtagttg      120

ccttccatgg atctatagga gagcaagtcc tccaggagaa gaagtcctca ccagtgaacg      180

gagacctctc tgaactaagg ataccatggc cacgtcagcc ccactacgga gcctggaaga      240

ggaggtgacc tgctccatct gtcttgatta cctgcgggac cctgtgacca ttgactgtgg      300

ccacgtcttc tgccgcagct gcaccacaga cgtccgcccc atctcaggga gccgccccgt      360

ctgcccactc tgcaagaagc cttttaagaa ggagaacatc cgacccgtgt ggcaactgga      420

aaaaatcctg aaccacctga gtaccctaag gagggacaga gacaaaattc agggcttcca      480

ggcaaaggga gaagctgata tcctggccgc gctgaagaag ctccaggacc agaggcagta      540

cattgtggct gagtttgagc agggtcatca gttcctgagg gagcgggagg aacacctgct      600

ggaacagctg gcgaagctgg agcaggagct cacggagggc agggagaagt tcaagagccg      660

gggcgtcggg gagcttgccc gg                                               682


<210> 3389
<211> 4065
<212> DNA
<213> Homo sapiens

<400> 3389
gccccattgg gccgggtgct ggggcatccc gggcgctggg tgccccgagc ggctacgacg       60

agtcccaggt ggggccgggc tccaggcccg cgggggagcg gagccgtgcg ccgcaggcgg      120

gctccgtgac gccgggtggg gaacgccggg ccggtggcgg gacttccgcc acgggactcg      180

gaaggggccg cgccgccgct gctgggagtt gtagtccggc cgtggttggg ggagccgcgg      240

ctcatgcgcg gtgcacagag gcttgtttca catctgtaac aacaggagga ggcccagcct      300

cgtgatgagg aatagcaagg agagaattca gctccagttc aaaagcctac aaaatctgag      360

actgtcattg cttttataag gattccagct ttccctcctg gccagaaatg ttcagcctgg      420

actcattcag aaaagatcgg gcccagcaca ggcagcgtca gtgcaaactt cccccacccc      480

gccttccacc catgtgtgtc aaccctaccc caggagggac catctctcga gcttctaggg      540

acctattaaa agagttccca cagcccaaaa atcttctcaa cagtgtgatt ggaagagccc      600

tcggcatctc acatgcaaaa gacaaactag tctacgtgca cacaaatgga ccgaagaaaa      660

agaaagtcac actgcacata aaatggccca agagcgtgga ggtagaaggc tatggcagca      720

agaagatcga tgctgagcgg caggctgcag ctgcagcctg ccagctgttc aagggttggg      780

gtctgctagg tccccggaat gagttgtttg acgcagccaa ataccgagtg ctagctgatc      840

gctttggctc ccctgccgac agctggtggc gtccggaacc caccatgccc cctacttcct      900

ggcggcagct gaatccagag agtattcgac cagggggacc tgggggccta tcccgctctt      960

taggccggga agaagaggag gacgaggagg aagagctaga agaagggacc atagatgtta     1020

ccgacttctt gtccatgacc cagcaggatt cccacgctcc actcagggac tcaaggggga     1080

gttcctttga gatgacagat gacgacagtg ccattagggc tctgacccag tttccacttc     1140

ccaagaacct tctggccaag gtgattcaga ttgcaacgtc atcctccaca gctaagaacc     1200

tcatgcagtt ccatactgtg ggcaccaaga ccaagctgtc tacactcacc ctgctctggc     1260

cctgccccat gacctttgtt gccaaagggc gccgcaaagc agaggctgag aataaggcgg     1320

cagccttggc ctgcaagaaa ctgaagagcc tgggcctggt ggacaggaac aacgaaccgc     1380

ttacacacgc catgtataac ctggcctctt tgcgtgagct gggtgagacc cagcgccgac     1440

catgcaccat ccaggtgccc gagcccatcc tccgcaagat agagaccttc ctgaaccatt     1500

accctgtgga gagttcatgg atcgccccag aactccggct gcagagtgat gacatcttgc     1560

ccttgggcaa ggactcaggg cctctgagtg accctatcac aggcaagccc tatgtgcccc     1620

tgttggaagc agaggaggta cgtctcagcc agagtctgct agaactgtgg cggcggcgag     1680

ggccggtctg gcaggaggcc ccccagctac ctgtggaccc acatcgggac accatcctca     1740

acgccattga gcagcacccg gtggtggtca tctctgggga cacgggctgt gggaagacca     1800

cgcgcatccc ccagctgttg ctggagcgct atgtgaccga gggccgaggt gcccgctgca     1860

atgttatcat cacccaacct cgccgcatct ctgctgtgtc tgtggcacag cgggtcagcc     1920

acgaactggg cccctccctg cgccggaatg tgggcttcca ggtgcggttg gaaagtaagc     1980

ccccatcccg aggcggggcc ctgctcttct gcactgtggg tatcctgctg cgtaagctgc     2040

agagcaaccc cagcctggag ggcgtgagcc acgtcatcgt ggatgaggtg catgagcggg     2100

acgtgaacac agactttctg ctgatcctgc tcaagggcct gcagcggctc aacccggccc     2160

tgcggctggt gctcatgagt gccacagggg acaatgagcg cttctcccga tactttggtg     2220

gctgccccgt catcaaggtg cctggcttca tgtacccagt caaggagcac tacctagagg     2280

acatcctggc caagttgggc aagcaccagt acctgcaccg gcaccggcac catgagtctg     2340

aggatgaatg cgcactcgat ttggaccttg tgactgatct ggttctgcac atcgatgctc     2400

gcggggaacc aggtgggatc ctgtgcttcc tgcctgggtg gcaggagatc aaaggagtgc     2460

agcagcgcct ccaggaggcc ctgggcatgc acgagagcaa gtacctcatc ctgccagtgc     2520

actccaacat ccccatgatg gatcagaagg ccatattcca gcagcctcca gttggggtgc     2580

gcaagattgt cttggccacc aacattgctg agacttccat cacaatcaat gacatcgtgc     2640

atgtggtgga cagtgggctg cacaaggaag aacgctatga cctgaagacc aaggtgtcct     2700

gcctggagac agtgtgggta tcaagagcca atgtgatcca gcgccggggc cgggcgggcc     2760

gctgccagtc cggctttgcc taccacttgt tccctcgaag ccggctggag aaaatggtcc     2820

ctttccaagt gccagagatc ctgcgcacac ctcttgagaa cctggtgctg caagcgaaaa     2880

tccacatgcc tgagaagacg gcggtggagt tcctgtccaa ggctgtggac agtccaaaca     2940

tcaaggcagt ggacgaggct gtgatcttgc tccaggagat cggggtgctg gaccagcggg     3000

agtacctgac taccctgggg cagcgcctgg ctcacatctc caccgacccc cggttggcca     3060

aggccattgt gttggctgcc atcttccgtt gcctgcaccc actactggtg gtcgtttcct     3120

gcctcacccg ggaccccttc agcagcagcc tacagaaccg ggcagaggtg gacaaggtga     3180

aagcactgtt gagccatgac agcggcagtg accacctggc ctttgtgcgg gctgtcgccg     3240

gctgggagga ggtgctgcgt tggcaggacc gcagctcccg ggagaattac ctggaggaaa     3300

acctgctgta cgcacccagc ctgcgcttca tccacggact catcaagcag ttctcagaga     3360

acatttatga ggccttcctg gtggggaagc cctcggactg caccctggcc tccgcccagt     3420

gcaacgagta cagtgaggag gaggagctgg tgaagggcgt gctgatggcc ggcctctacc     3480

ccaacctcat ccaggtgagg cagggcaagg tcacccggca ggggaagttc aagcccaaca     3540

gcgtcacata taggaccaaa tcaggcaaca tcctgctgca caagtcgacc attaacaggg     3600

aggccacacg gttacggagc cgatggctga cgtatttcat ggcagtcaag tccaatggca     3660

gcgtcttcgt ccgggactcc tctcaggtgc acccgctagc tgtgctgctg ctgaccgacg     3720

gggacgtgca catccgtgat gacgggcgcc gggccaccat ctcactgagc gacagtgacc     3780

tgctgcggct ggagggtgac tcgcgtaccg tgcggctgct gaaggagctg cggcgggccc     3840

tgggccgcat ggtggagcgg agcctgcgca gcgagctggc tgcacttccc cccagcgtac     3900

aggaggagca cgggcagctg cttgcgctac tggcagagct gctgcgagga ccctgtggca     3960

gctttgatgt gcgcaagaca gctgacgact gagccctgct tctgctgggg ctgtgtacag     4020

agtgcaaatg tttatttaaa ataaagttct atttatccct tgtga                     4065


<210> 3390
<211> 575
<212> DNA
<213> Homo sapiens

<400> 3390
attctttccc tctctcattt gcctctctct tgcttttttt ccttcagaca cttggattgg       60

acttaatctt aaacctctgg agttcaagac cttttaaaaa gggctaaata aacaatctct      120

acatgtaaaa ggccactgac tcctacttcc tctgtataga gcaactgttg aactcagctg      180

cctgtagagc gagaatagga cagactcgta taccattctg atctgggtgc atttcttcag      240

aagggcgtga ttctcagtca ccagactcag caaaaggttt tagaagcgtt cgaccaaacc      300

tacaagataa aagatcacca actcagagcc agataacagt gaatggaaac tcaggaggtg      360

ccgtgagtcc catgagttac tatcagaggc cgttttcccc ctcggcatat tctctcccag      420

cctcactcaa ctccagcatt gtcatgcagc acggcacatc cctcgattcc acagacacat      480

atccccagca tgcgcagtct ctggatggca ccaccagcag ctctatcccc ctgtaccgat      540

cctcagagga agagaagaga gtgacagtca tcaaa                                 575


<210> 3391
<211> 2397
<212> DNA
<213> Homo sapiens

<400> 3391
ctatgagcag acgtgtggtt cggcaaagca agttccgcca tgtgtttggg caggcagcaa       60

aggccgacca ggcctacgag gacatccgtg tgtccaaggt cacatgggac agctccttct      120

gtgccgtcaa ccccaaattc ctggccatta ttgtggaggc tggaggcggg ggtgccttca      180

tcgtcctgcc tctggccaag acagggcgag tggataagaa ctacccactg gtcactgggc      240

acactgcccc tgtgctggat attgactggt gtccacacaa tgacaacgtt atcgccagtg      300

cctcagacga caccaccatc atggtgtggc agattccaga ctataccccc atgcgcaaca      360

ttacggaacc tatcatcaca cttgagggcc actccaagcg tgtgggcatc ctctcctggc      420

accctactgc caggaatgtc ctgctcagtg caggtggtga caatgtgatc atcatctgga      480

atgtgggcac cggggaggtg ctgctgagcc tggatgatat gcacccagac gtcatccaca      540

gtgtgtgctg gaacagcaac ggtagcctgc tagccaccac ctgcaaggac aagaccttgc      600

gcatcattga ccccagaaaa ggccaagtgg tggcggagca agcccggcct cacgagggcg      660

cccgcccgct gcgggctgtc ttcaccgcag acgggaagct gctcagcacc ggcttcagca      720

ggatgagtga gcggcaactc gcgctctggg acccgaacaa cttcgaggag ccagtggcac      780

tgcaggagat ggacacaagc aacggggtcc tattgccctt ttacgatccc gactccagca      840

tcgtctacct gtgtggcaag ggcgacagca gcattcggta ctttgagatt accgacgagc      900

cgcctttcgt gcactacctg aacacgttca gcagcaaaga gccgcagcgg ggcatgggtt      960

tcatgcccaa aaggggactg gatgtcagca agtgtgagat cgcccggttc tacaagctac     1020

acgaaagaaa gtgtgaacct atcatcatga ctgtgccccg caagtcagac ctcttccagg     1080

acgatctgta cccggatacg ccaggcccgg agccggccct agaagcggac gaatggctat     1140

ccggccagga cgccgaaccc gtgctcattt cgctgaggga cggctatgtg ccccccaagc     1200

accgcgagct ccgggtcacg aagcgcaaca tcctggacgt gcgcccgccc tccggccccc     1260

gccgcagcca gtcggccagc gacgccccct tgtcgcagca gcacaccctg gagacgctgc     1320

tggaagagat caaggccctc cgcgagcggg tgcaggccca ggagcagcgc atcacggctc     1380

tggagaacat gctgtgcgag ctggtggacg gcacggacta gccccgcgcg ccaggcaggc     1440

ggagcggggc ggggcgcaca agctcggccc cgccccggct tttagtcccg aactccggac     1500

cccgccttct tgggctgggc ccgggggcgg gactggggag ggaactccgc ccctcgcggg     1560

agaccagaac tcttggagct taggggagac ccacgtcgct ccagcggagg ctggactgcg     1620

agcctcgtct gggactcggc tggagctggc ctagggaggc ctggggtaac ctggggggct     1680

cagcaatggt gctgcacggc gaggtggtgt ccccctttgt cctccgccca gggcagggaa     1740

agtgcttagt attagcgtga tgcttggggt tattggagcc tgagcttgac ctcaaacggg     1800

tggcgatttg atgggtaccc ccaggctggg gaaaatgaca gcgcttctcc taatcagctc     1860

actggattcc atcaccctga gcggtaaacc agatgggcgt caccccagtt ctgcagacac     1920

atacacaacc cgtttgctgc agagccggac ccagtggcta cacccacagc ggtctgtggt     1980

agagaactct cttccttctt tccaccgaca ggggcgaggg ctgcttcctc gcggcagccc     2040

ccgcgaagaa atctcgagag aactggcatg aggagttagg ttcatcacaa atacacacac     2100

actgccccca accctctgcc gttgcctctc tcagaaaaac aagacgtact gaatgaaata     2160

ttttactaag cgttcagtct gtgcctcctg catgggtggg agtgagggga acgagacccc     2220

cagcctctgc aaatgctacc cccaggctcc tgggagacct ggcgatgcac tcctgggctc     2280

agggtccatc aggcagcctc ttaccctaga gctctctcca ctctgaggtt cagaaggacc     2340

ccaacccaca ccgtaggcgt tccccccaag taaagttagg tagcaaaagc ctccggt        2397


<210> 3392
<211> 389
<212> DNA
<213> Homo sapiens

<400> 3392
atacttcact cgctggtaca aaccggaata tgtgtcatca cattggcaga atctcatcca       60

gttcttcaaa gtggaaaaac aattaaaagc atttcctatc agatcagtac caactgtagc      120

agacttcaga acaaggtctc tgggaaattt aagcgggggg cacagtttct aacagagctt      180

gcacctctct gtaagattta ctgctcagat ggtgaagaat atactgtgtc tagttgtgtt      240

agaggacgtt tgatggaagt gaatgaaaac atcctccata agccatctat tcttcaagaa      300

aagccatcta ctgaaggcta cattgcagtt gtgttaccca aatttgaaga aagtaaaagc      360

ataacagaag ggttactgac acaaaaaca                                        389


<210> 3393
<211> 1645
<212> DNA
<213> Homo sapiens

<400> 3393
ttttctttgt gcctataata taattggctg attgtgcggg tgatgagcgc cccctccccc       60

agcccggtcc cagctccatg ttcctaagcc tgcctcactg gtttcggagg gctggagagc      120

agctcagctc gctagctgcg cgcttcccgg cacaggcagt gccactgcgc aggttgatca      180

gcgaaacagc atccatttta atctgcgggg agcccctgcc ttaccagggc gttctctccg      240

cccgccggtg gatgctccgc gcctgccctc cgcagcctcg ctcagcagtc ctgcgttggg      300

gtctgcgccc taggatgcac tgagatggta catcaggata actgctcgta tcaggcacag      360

aaaaatgaga gagagtctat cagacagaag ttggcacttg gaagcttctt tgatgatggc      420

ccaggaattt ataccagctg tagcaaaagt gggaagccaa gcctttcctc ccgactgcag      480

agtgggatga acttgcagat atgctttgtc aacgacagtg gcagtgataa ggacagtgat      540

gctgatgaca gtaagactga aaccagcttg gacaccccct tgtctcccat gagcaaacag      600

agttcttcct attctgatag agacactact gaagaggagt ctgaatcctt ggatgacatg      660

gacttcctta caaggcaaaa gaaattgcaa gctgaagcca aaatggccct tgccatggcc      720

aaaccaatgg ccaaaatgca agtagaagtg gagaaacaga acaggaaaaa gtctcccgtc      780

gctgatcttc tgccacacat gcctcatata agtgaatgct tgatgaaaag aagtttaaaa      840

cccaccgacc tgagagacat gactattggg cagctacaag tgatagtcaa tgatctccat      900

tcccagatag aaagcttgaa tgaagagttg gtccagctgc ttctcatccg agatgagctg      960

cacacagagc aggatgccat gctggtggac attgaagact tgaccagaca tgctgaaagt     1020

cagcagaagc acatggcaga gaaaatgcct gcaaagtgaa aagaagccat tcaaccagag     1080

aacaagctag aatttatttt gcttctgtgg ttgtaaaaat gctgttgcta aaggtggcgc     1140

agaaacaaat atcagtgtta gtcattgata atgtctgaag cttaatgtcc agtgattggc     1200

ctttgcttct taatttattt taatttttta cttgtgccac ttaatatcag gcattttaat     1260

aaaatattgt tacaaaaaat gtacagtact gacaccacca caaatcatgg ttaataaaag     1320

agagtagttt taactttatt tttatttgtt tagagatttt aagttggaac agtattttcc     1380

cattgactac ttttcattct tcactgtagt tttaaagaag aactgtaaat gacggtgcta     1440

tacaagtcaa aaaatacatg cctgcctcgt agtgaagttg tagctctccg taatatgtat     1500

attttactca gttttcaaca ttttgtgaat gttgactacc tgaagttcct ttttagatgt     1560

gctattaaca ttctgttgga ttcagagggt tccttgaaag ttttatgtat aaatatgtaa     1620

aataaaaatt aaaactttgt ttcat                                           1645


<210> 3394
<211> 3478
<212> DNA
<213> Homo sapiens

<400> 3394
aacagaccgc cgtgagagag gaggggcgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cggttgcttc      180

attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt      240

gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc tgtcgattga      300

ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt actgtgcttg      360

ctcctgactc tatgtcgcgt ctccaaggag aagaagtcct caccagtgaa cggagacctc      420

tctgaactaa ggataccatg gccacgtcag ccccactacg gagcctggaa gaggaggtga      480

cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt ggccacgtct      540

tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc gtctgcccac      600

tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg gccagcctgg      660

tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag gtgacccggg      720

agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac tactgtgagg      780

acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg      840

ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac cacctgagta      900

ccctaaggag ggacagagac aaaattcagg gcttccaggc aaagggagaa gctgatatcc      960

tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag tttgagcagg     1020

gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg aagctggagc     1080

aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag cttgcccggc     1140

tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca gagctcatgc     1200

aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt gggaaaccca     1260

ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc tctctgcaac     1320

gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag acagtgagcg     1380

tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac tggaagtgcg     1440

tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt gactgtgagc     1500

ctggggtgct gggcagcaag ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg     1560

agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag ggagaagagg     1620

aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa acggacgaag     1680

atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag gaagttctgg     1740

aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac ctctccctgc     1800

ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg gccaacacca     1860

gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc gccctggatt     1920

atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc tacaccttca     1980

ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca ggaacacgcc     2040

tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag atgcttcact     2100

tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag cacctggagc     2160

aggggacccc atatccactg gtagccacct ccccattgct gtggccccct gaaatctcac     2220

tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc ctgctggttt     2280

cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg accacgacct     2340

tggccccagc tctgcactct ctggaataag ggcccgatgc agcattttct tgcccagtgt     2400

ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt ccttaaaccc     2460

cccaggttcc ttcttgcaca aatccactct gctgcccacc ttccctggca ttttaaacag     2520

acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat aaacaaaatc     2580

cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat ctcatggggt     2640

ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat agccaaggag     2700

gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac acggctttgg     2760

ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg tgaggggagt     2820

tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca agacaaacat     2880

ccagtggagc agaacctctc ctgcctcggg agttctgacc aggttcccca gcagggtgtt     2940

aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag agagtggaga     3000

tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa     3060

gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca ggtgcccctc     3120

atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc agtcttgtcc     3180

ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc ctccaccctg     3240

ttctaagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac cattgtctca     3300

gagctgccca ctttgtgtgt gtcacatgct gcctgagtca cacgtacatc ttatttctgc     3360

ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt gtattctcat     3420

ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt tgaatgaa       3478


<210> 3395
<211> 836
<212> DNA
<213> Homo sapiens

<400> 3395
ctccgcacct ctccatctgc cgggaagatc tgtgggacaa gatccccccc cgccctctgg       60

cctctccctc tggatgcccc atgctctttc tgggctgctt tggggctctg gcggctgggg      120

ggagcggggg gctgacccaa ggcgggttac acagagagga aggtgacggg gataggccct      180

cggcaggaca ggcctactcc aggatcggac ctacctgagc cctgtggggt ggctgtccat      240

gttggccctg gtccatcagg aggaggaaag aagggagact ttggcccagg cttctaggac      300

gtgtgaccga gagctcctgg gcctgtgtcc ccccaggtgg tggaattggg catcctggac      360

cagctctcca ctgaggagcg gaaaaggcag gaggccatgt tcgagatcct cacgtcggag      420

ttctcctacc agcacagcct gagcatcctg gtggaggagt tcctgcagtc caaggagctg      480

cgggcgaccg tgacccagat ggagcaccac cacctcttct ccaacatcct ggatgtcctg      540

ggtgccagtc agaggttctt cgaggacctg gagcagcggc acaaggccca ggtgctggtc      600

gaggacatca gtgacatcct ggaggagcac gctgagaagc acttccaccc ctacatcgcc      660

tactgctcca acgaggtcta ccaacagcgc acgctgcaga agctgataag cagcaacgcc      720

gccttccgag aggccctgag agagattgag aggcggccgg cgtgcggggg cctgcccatg      780

ctctccttcc tgatcctccc catgcagcgg gtgacccggc tgcccctcct gatgga          836


<210> 3396
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 3396
ccggagcggg gatcacctca acttgactgt ggtcccccag ccctccaaga aatgcccata       60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa      120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt      180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt      240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca      300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc      360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc      420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc      480

tcctccatcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc      540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg      600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc      660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg      720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct      780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc      840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc      900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac      960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga     1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg     1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg     1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct     1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc     1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta     1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct     1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat     1440

ataattcccc tctgga                                                     1456


<210> 3397
<211> 546
<212> DNA
<213> Homo sapiens

<400> 3397
agcacaacaa tcatttgttg agagcctact caagactctg tacttgtccg tgacagtcac       60

tgggagcata gcctttctcc aatgacatcg ccctgaacat ccactctaaa aatgcagggc      120

gtgattctca gtcaccagac tcagcaaaag gttttagaag cgttcgacca aacctacaag      180

ataaaagatc accaactcag agccagataa cagtgaatgg aaactcagga ggtgccgtga      240

gtcccatgag ttactatcag aggccgtttt ccccctcggc atattctctc ccagcctcac      300

tcaactccag cattgtcatg cagcacggca catccctcga ttccacagac acatatcccc      360

agcatgcgca gtctctggat ggcaccacca gcagctctat ccccctgtac cgatcctcag      420

aggaagagaa gagagtgaca gtcatcaaag ccccgcatta cccagggatc gggcccgtgg      480

atgaatccgg aatccccaca gcaattagaa cgacagtcga ccggcccaag gactggtaca      540

agacga                                                                 546


<210> 3398
<211> 552
<212> DNA
<213> Homo sapiens

<400> 3398
ggccgggatt cgcggcccgg agctcgggac cggagtcagg aatggagaga agggtaatgg       60

ttttacctct tattgtggaa acctgttgag atcacagaga atatactgac ggcataaaag      120

ggcagaacca tagcagggtg cgaagtcctc accagtgaac ggagacctct ctgaactaag      180

gataccatgg ccacgtcagc cccactacgg agcctggaag aggaggtgac ctgctccatc      240

tgtcttgatt acctgcggga ccctgtgacc attgactgtg gccacgtctt ctgccgcagc      300

tgcaccacag acgtccgccc catctcaggg agccgccccg tctgcccact ctgcaagaag      360

ccttttaaga aggagaacat ccgacccgtg tggcaactgg ccagcctggt ggagaacatt      420

gagcggctga aggtggacaa gggcaggcag ccgggagagg tgacccggga gcagcaggat      480

gcaaagttgt gcgagcgaca ccgagagaag ctgcactact actgtgagga cgacgggaag      540

ctgctgtgcg tg                                                          552


<210> 3399
<211> 808
<212> DNA
<213> Homo sapiens

<400> 3399
gggtctccct gccaagctat gggggagggg atggtggaca tgacaacttc cagctcagcg       60

gtgctttagg agattttgat tcgctttcca aggacaatgt cttcgagaat aaccgtttgg      120

cctttgaagt ggctgagaag gagctgggga tccccgctct cctggacccc aatgacatgg      180

tctccatgag cgtccctgac tgcctcagca tcatgaccta tgtgtcccag tattacaacc      240

acttctgcag tcctggccaa gctggtgtct cgccacccag aaagggcctt gcaccctgtt      300

ccccgccgtc tgtagcaccc actccagtgg aaccagaaga tgtggctcag ggcgaggagc      360

tctcctcagg cagcctgtca gagcagggca ccggccagac ccccagcagc acgtgcgcag      420

cctgccagca gcatgtgcac ttggtgcagc gctacctggc tgacggcagg ctgtaccatc      480

gccactgctt ccggtgtcgg cggtgctcca gcaccctgct ccctggggct tatgagaatg      540

ggcctgagga gggcaccttt gtgtgtgcag aacactgtgc caggctgggc ccggggacac      600

ggtcggggac caggcctggg cccttctcac agccaaagca gcagcaccag cagcaactcg      660

cagaagatgc caaggatgtt ccaggaggcg gccccagctc cagtgctcct gcaggggctg      720

aggccgatgg acccaaggcc agccctgagg cccggccgca gatccctacc aagccccggg      780

ttcctggcaa actacaggag ctggccag                                         808


<210> 3400
<211> 884
<212> DNA
<213> Homo sapiens

<400> 3400
atcttgagtg agggcacgct ctccttagag gggcggaaca gtttttggca ccttatcgcg       60

agcggcagct tatgcaagag tgacttaaaa aagaaaggca ggtccggggc caggggctaa      120

gtagcggtgc ggtttctttt tctggattag tttccccatc ttgcctaaaa atgtcctagt      180

ctagtctttt tagcagaact ccactcccta aacatgtcag aactacactt cccatcaagg      240

gtcagaaaga aacttccggc acagtctttt cccagcattc cttgtttact tccgggttta      300

ttactactga aggaagaacg ccagatcaga aaagggagct caggtacctt ccagagagtg      360

agacccagcg cccttgtctc gcacccagta ggctttcatc cccgccatgg cggagctgat      420

ccagaagaag ctacagggag aagtggagaa atatcaacag ctacagaagg acttaagtaa      480

atccatgtcg gggaggcaga aacttgaagc acaactaaca gaaaataata tcgtgaaaga      540

ggaactggcc ctgctggatg ggtccaacgt ggtctttaaa cttctgggtc cggtgctagt      600

caaacaggag ctgggggagg ctcgggccac agtagggaag aggctggact atatcacagc      660

tgaaattaag cgatacgaat cccagcttcg ggatcttgag cggcagtcag agcaacagag      720

ggagaccctt gctcagctgc agcaggagtt ccagcgggcc caggcagcaa aggcaggggc      780

tcctggcaag gcctgacccc atggtggggg gaggggaggg gaggggaggg aatgaggcag      840

ctctaggatc tatactgtag ctaataaaat gtaaaaacac ctgg                       884


<210> 3401
<211> 817
<212> DNA
<213> Homo sapiens

<400> 3401
cagaaacaaa cagcccaaat tactttatca ccatggcttt gaacgttgcc ccagtcagag       60

atacaaaatg gctgacatta gaagtctgca gacagtttca aagaggaaca tgctcacgct      120

ctgatgaaga atgcaaattt gctcatcccc ccaaaagttg tcaggttgaa aatggaagag      180

taattgcctg ctttgattcc ctaaagggcc gttgttcgag agagaactgc aagtatcttc      240

accctccgac acacttaaaa actcaactag aaattaatgg aaggaacaat ttgattcagc      300

aaaaaactgc agcagcaatg cttgcccagc agatgcaatt tatgtttcca ggaacaccac      360

ttcatccagt ggcctttccc cctggtgctc ttcatccttt accaaagaga caagcacttg      420

aaaaaagcaa tggtaccagc gcggtcttta accccagcgt cttgcactac cagcaggctc      480

tcaccagcgc acagttgcag caacacgccg cgttcattcc aacagataat tctgaaataa      540

tcagcagaaa cggaatggaa tgccaagaat ctgcattgag aataactaaa cattgttact      600

gtacatacta tcctgtttcc tcctcaatag aattgccaca aactgcatgc taaataaaga      660

tgtagttctt ctggacagac cacaactcta agaagctagt gctgctatct catatatgag      720

tattaaatat ggtatgctta gtatattcca acctaagata gttaactacc tgagaccagc      780

tgtgatgttt aaagacataa aggataaagt ttacttt                               817


<210> 3402
<211> 1285
<212> DNA
<213> Homo sapiens

<400> 3402
tacatgcaac agccagtgag agcaggagac atcggtgttt ccagagtcca gacccaccac       60

aatgccagcc ccttctcagt tccgaagaaa caggatgaat cacccatgat tggggatgga      120

gaagattatt tcctttcttt gtttggtgat tcaaagaaac ttacagcaca ctcaaactac      180

actcagaaaa ctttaaaata cttttctatg attcttgaag aagttggcca atttacctcc      240

agttctcttg gagatgttga aatagctgaa gtgaatgtca agggtttgtt cgtgaagctc      300

attaactctt cccttgacaa agaaatggca attggagatc atattctcca gcaaaatgtg      360

aatggacaaa ccatttcttt gtaccgattc cttccaaaca tcgtaatgca ggcaaattcc      420

acagtaacag tgtgggcagc agcatctgaa gcaaagcatc aacctccatc agattttctt      480

tggaaggaac aagacaagtt tagagcaagt cctgattgta taacaatcct gtgcaaaccg      540

aacggtcaag ccattgcgtg gtacacccct atccactgga agcaagcgtg ggaaaaatta      600

gatgctgacg ttgaatttaa cagatgttca gtagtatctc caacattccg aaagcgtgtg      660

tttcagtgga cagcatctac agctacaata actaaagaaa aacaagatca acctaagaaa      720

gatatctcaa attatcaggt ggaacaagct caagttcttc ttaagagaga gaaggaaatc      780

ccaccaaccg ttttccctaa tcgcagccct tggtgccaga atccctatgt ctctgcacat      840

ccttactgtc ctctgattga accacacaat acatccaccg ctggaggcag attggataga      900

cagcccagga ctcggtcaac cagacctaat cgagcctcag ggtctaagaa aaagaagaca      960

tctgagtcac aaaagcaata agcagtcaac tcaaccttta aagatggagt ctcactctgt     1020

tgcccaggct ggagtgcagt ggtgtgatct ccactaactg cagcctccgc ctcccaggtt     1080

caagtgagtc tcctgcgtca gcctcccgag tagctgggat tacaggcatc cgccaccctg     1140

catggctaat ttttgtattt ttagtagcaa cgaggtttca ccatgttggc caggctggtc     1200

tcgaattcct gacctcaggt gatctgcctg ccttggcctc ccaaagtgct gggattacac     1260

gcatgagcca ccatgcccgg cgcaa                                           1285


<210> 3403
<211> 1490
<212> DNA
<213> Homo sapiens

<400> 3403
agccagttcc tagcgcagag ccgcgcccgc catgagggag atcgtgcaca tccaggcggg       60

ccagtgcggg aaccagatcg gcaccaagtt ttgggaagtg atcagcgatg agcacggcat      120

cgacccggcc ggaggctacg tgggagactc ggcgctgcag ctggagagaa tcaacgtcta      180

ctacaatgag tcatcgtctc agaaatatgt gcccagggcc gccctggtgg acttagagcc      240

aggcaccatg gacagcgtgc ggtctgggcc ttttgggcag cttttccggc ctgacaactt      300

catctttggc cagacgggtg cagggaacaa ctgcctgcag ggcttccagc tcacgcactc      360

gctgggcggc ggcacgggct caggcatggg cacgctgctc atcagcaaga tccgtgagga      420

gttcccggac cgcatcatga acaccttcag cgtcatgccc tcgcccaagg tgtcggacac      480

ggtggtggag ccctacaatg ccacactgtc ggtgcaccag ctggtggaga atacagacga      540

gacctactgc atcgacaacg aggcgctcta tgacatctgc ttccgcactc tgaagctgac      600

aacgcccacc tacggggacc tcaaccacct ggtgtccgcc accatgagtg gggtcaccac      660

ctcgctgcgc ttcccgggcc agctcaatgc tgacctgcgc aagctggcgg tgaacatggt      720

gcccttcccg cgcctgcact tcttcatgcc tggcttcgcg ccgctcacca gccgcggcag      780

ccagcagtac cgggccctga ccgtgcccga gctcacccag cagatgttcg acgccaggaa      840

catgatggcc gcctgcgatc cgcgccatgg ccgctacctg accgtggcca ccgtgttccg      900

cgggcccatg tccatgaagg aggtggacga gcagatgctg gccatccaga gtaagaacag      960

cagctacttc gtggagtgga ttcccaacaa cgtgaaggtg gccgtgtgcg acatcccgcc     1020

ccgcggcctg aagatggcct ccaccttcat cggcaacagc acggccatcc aggagctgtt     1080

caagcgcatc tccgagcagt tctcagccat gttccggcgc aaggccttcc tgcactggtt     1140

cacgggtgag ggcatggatg aaatggagtt caccgaggcg gagagcaaca tgaacgacct     1200

ggtatccgag taccagcagt accaggatgc caccgccaat gacggggagg aagcttttga     1260

ggatgaggaa gaggagatcg atggatagtc ggaatagagc cgccccaact cagatcctac     1320

aacacgcaag ttccttcttg aaccctggtg cctcctaccc tatggccctg aatggtgcac     1380

tggtttaatt gtgttggtgt cggcccctca caaatgcagc caagtcatgt aattagtcat     1440

ctggaacaaa gactaaaaac agcagagaat tgcgggttct acccagtcag                1490


<210> 3404
<211> 963
<212> DNA
<213> Homo sapiens

<400> 3404
agctttgcgc tcgtgggaga gtcccgcctc cttctgcgaa ccgcaccacc cagatcccgg       60

ggtgcgcgga gggcgcgtct ctgacggaag ccggggcgga cggtcggagt ccggaagaaa      120

aacagtccgc gacagctagg cgcgtgagac cggccgcccg cagggctgct ctggccggga      180

cccgctggcc gggagacgcg aacctgccgg accaccgcgc ggggacgacg gcggccatga      240

gctcgcggaa gctgagcggg ccgaaaggca ggaggctcag cacatacatc aggaggtctg      300

cctgatccca tggtgaaccc cgggaatccg aaatcagatt gagataagat cctttaggga      360

agtgacttag cctggtctct tgcctgctct ttcacgggga acaacgctaa tcgcccactt      420

agtctaagtc acgatgcttg gatttgctgc taatcgtcgg atttgagagt gggaacaaga      480

aatccggact tttgctctcc atcctcttag acatacacgt cgtgacttgg aacgtggctt      540

cggcagcgcc ccctctagat ctcagtgacc tgcttcagct gaacaaccgg aacctcaatc      600

ttgacatata tgttattggt ttgcaggaat tgaactctgg gatcataagc ctcctttccg      660

atgctgcctt taatgactcg tggagcagtt tcctcatgga tgtgctttcc cctctgagct      720

tcatcaaggt ctcccatgtc cgtatgcagg ggatcctctt actggtcttt gccaagtatc      780

agcatttgcc ctatatccag attctgtcta ctaaatccac ccccactggc ctgtttgggt      840

actgggggaa caaaggtgga gtcaacatct gcctgaagct ttatggctac tatgtcagca      900

tcatcaactg ccacctgcct ccccacattt ccaacaatta ccagcggctg gagcactttg      960

acc                                                                    963


<210> 3405
<211> 2099
<212> DNA
<213> Homo sapiens

<400> 3405
ggggacgtaa cggaggcagg ttggagccgc tgccgtcgcc atgacccgcg gtaaccagcg       60

tgagctcgcc cgccagaaga atatgaaaaa gcagagcgac tcggttaagg gaaagcgccg      120

agatgacggg ctttctgctg ccgcccgcaa gcagagggac tcggagatca tgcagcagaa      180

gcagaaaaag gcaaacgaga agaaggagga acccaagtag ctttgtggct tcgtgtccaa      240

ccctcttgcc cttcgcctgt gtgcctggag ccagtcccac cacgctcgcg tttcctcctg      300

tagtgctcac aggtcccagc accgatggca ttccctttgc cctgagtctg cagcgggtcc      360

cttttgtgct tccttcccct cagtttgttc gtctgcttga aagttggcca aaaaatcctg      420

ctgctcaccg acttcccgtg gtcagctgct gtcaagcgtt cactttctct tctgtcattc      480

ctcatggaat gagggtggtt ttgtcttccc gcttcccttg acctcaaaat caggattaaa      540

acctggggta gcctctgtgc tcctttcttc tatgccctgg tttgttctgt ggttctgggc      600

ttcttatatc cgtgtgccca gggctgaact ccttattttc ctttctccaa gggcagagcc      660

gagtcttcag tccctgttgg tctttcccca cccccacttc cagcccaaga gccaggaaag      720

ggctggtgcc acactgtctg ctgggatcag cggtggttct ttgagctgct gatttgggtg      780

ttaggctctt gagctgggat gcagatgtaa cagtagctcc agtgagtcag acactctgcc      840

cagcacatta gactgtgttt gaccacttct tccagttcat agtattgact tcagcccaaa      900

cggagataac tccctgtgtg tccttgaggt attgagctgg gctggacagc tccccttgag      960

ccaactctag gagtacaatg tcaggggaac cccagtttgt gaaaaggact tagactggag     1020

gatatttgtt atctggggat atgatgcggt ggcggcggcg cctcaagata aggggctggg     1080

gtttctgggt ggggggccaa cagagtggtg ccagtaacag ccccagatag aggagtacgc     1140

aggcccagca tgaggcaacc ttgacccaga aggtggccca gctacccttg atgaaggtct     1200

tttccagttc tgctccctca tagctgtgta accaaaggct ctggttagag aatatgaagg     1260

gccttagctt ttagacctgt tctacctcct caccaaatat aatggcagac ccatgtgtgt     1320

ctggaatggc cttgaattgc tctttcctta aaatagctag ctcttcagga gagtatctaa     1380

ggcccactcc atcttacctg aaccagttgg taagggtaac catgacatag agtgaggcaa     1440

ggaagaagac gaagtggaag gcagaatagt tgtaggaaag atgctggact tggactggag     1500

gagctggagg ggtttcttgg tcagctggcc tcgcagcccc acccctttgc cctggagaga     1560

ggaaatggct gctgggagca gagctgctga aacacctctt cccctctccc ccaactacct     1620

ttgttaaggc tcttgagggt tcttatggca ctccacagag atctaccact tcttatggtt     1680

cctcacttgg cactcacctt tgtctgcctc cactgtttca gggcagcaga aacacagtga     1740

gggcttctgc aaaacagaac gcaggttttg gaatggtctt aaaagatgtg agggtgttaa     1800

tctaggaaac ttcccccgtg aaaagattgg tctagtatta aaaagtggag gcacacctgg     1860

gttcaaattc tagctccagc atataagtgg ctgtgcagac tttggtaaga tgtttaatct     1920

tttgtgcctc gatttctcca tttgtaaaat ggagcaaata cctacctcac agggttgttg     1980

tgagggttaa attaaatgag attatgtaaa agtatctagc acagttgcct agcacattgt     2040

gggtactcaa taaaaggtaa cagcagctat aatctgagca ttctgggtag aggttggta      2099


<210> 3406
<211> 861
<212> DNA
<213> Homo sapiens

<400> 3406
atggatgaaa ctgagattgg aagctgcttt ggtagatacg gttcagtgaa agaagtgaag       60

ataatcacga atcgaactgg tgtgtccaaa ggctatggat ttgtttcgtt tgttaatgac      120

gtggatgtcc agaagatagt aggatcacag atacatttcc atggtaaaaa gctgaagctg      180

ggccctgcaa tcaggaaaca aaagttatgt gctcgtcatg tgcagccacg tcctttggta      240

gttaatcctc ctcctccacc acagtttcag aacgtctggc ggaatccaaa cactgaaacc      300

tacctgcagc cccaaatcac gccgaatcct gtaactcagc acgttcaggc ttactctgct      360

tatccacatt caccaggtca ggtcatcact ggatgtcagt tgcttgtata taattatcag      420

gaatatccta cttatcccga ttcagcattt caggtcacca ctggatatca gttgcctgta      480

tataattatc agccatttcc tgcttatcca agatcaccat ttcaggtcac tgctggatat      540

cagttgcctg tatataatta tcaggcattt cctgcttatc caaattcacc atttcaagtc      600

gccactggat atcagttccc tgtatacaat tatcagccat ttcctgctta tccaagttca      660

ccatttcagg tcactgctgg atatcagttg cctgtatata attatcaggc atttcctgct      720

tatccaaatt caccatttca agtcgccact ggatatcagt tccctgtata caattatcag      780

gcatttcctg cttatccaaa ttcaccagtt caggtcacca ctggatatca gttgcctgta      840

tacaattatc agaaatttcc t                                                861


<210> 3407
<211> 4867
<212> DNA
<213> Homo sapiens

<400> 3407
gcaggcgcgc cctggcaccc gggccaagac gcccggagcg gctgctgcag ccagtagcgg       60

ccccttcacc ggctgccccg ctcagaccta gtcgggaggg gtgcgaggca tgcagctggg      120

ggcccagctc cggtgccgca ccccgtaaag ggctgatctt ccacctcgcc acctcagcca      180

cgggacgcca agaccgcatc caattcagac ttcttttggt gcttgtgaaa ctgaacacaa      240

caaaagtatg gatatgggaa accaacatcc ttctattagt aggcttcagg aaatccaaaa      300

ggaagtaaaa agtgtagaac agcaagttat cggcttcagt ggtctgtcag atgacaagaa      360

ttacaagaaa ctggagagga ttctaacaaa acagcttttt gaaatagact ctgtagatac      420

tgaaggaaaa ggagatattc agcaagctag gaagcgggca gcacaggaga cagaacgtct      480

tctcaaagag ttggagcaga atgcaaacca cccacaccgg attgaaatac agaacatttt      540

tgaggaagcc cagtccctcg tgagagagaa aattgtgcca ttttataatg gaggcaactg      600

cgtaactgat gagtttgaag aaggcatcca agatatcatt ctgaggctga cacatgttaa      660

aactggagga aaaatctcct tgcggaaagc aaggtatcac actttaacca aaatctgtgc      720

ggtgcaagag ataatcgaag actgcatgaa aaagcagcct tccctgccgc tttccgagga      780

tgcacatcct tccgttgcca aaatcaactt cgtgatgtgt gaggtgaaca aggcccgagg      840

ggtcctgatt gcacttctga tgggtgtgaa caacaatgag acctgcaggc acttatcctg      900

tgtgctctcg gggctgatcg ctgacctgga tgctctagat gtgtgcggcc ggacagaaat      960

cagaaattat cggagggagg tagtagaaga tatcaacaaa ttattgaaat atctggattt     1020

ggaagaggaa gcagacacaa ctaaagcatt tgacctgaga cagaatcatt ccattttaaa     1080

aatagaaaag gtcctcaaga gaatgagaga aataaaaaat gaacttctcc aagcacaaaa     1140

cccttctgaa ttgtacctga gctccaaaac agaattgcag ggtttaattg gacagttgga     1200

tgaggtaagt cttgaaaaaa acccctgcat ccgggaagcc aggagaagag cagtgatcga     1260

ggtgcaaact ctgatcacat atattgactt gaaggaggcc cttgagaaaa gaaagctgtt     1320

tgcttgtgag gagcacccat cccataaagc cgtctggaac gtccttggaa acttgtctga     1380

gatccaggga gaagttcttt catttgatgg aaatcgaacc gataagaact acatccggct     1440

ggaagagctg ctcaccaagc agctgctagc cctggatgct gttgatccgc agggagaaga     1500

gaagtgtaag gctgccagga aacaagctgt gaggcttgcg cagaatattc tcagctatct     1560

cgacctgaaa tctgatgaat gggagtactg aaataccaga gatctcactt ttgatactgt     1620

tttgcacttc atatgtgctt ctatgtatag agagctttca gttcattgat ttatacgtgc     1680

atatttcagt ctcagtattt atgattgaag caaattctat tcagtatctg ctgcttttga     1740

tgttgcaaga caaatatcat tacagcacgt taacttttcc attcggatca ttatctgtat     1800

gatgtggtgt ggtttgtttg gtttgtcctt ttttttgcgt ttttaatcag aaaacaaaat     1860

agaggcagct tttgtagatt ttaaatgggt tgtgcaagca ttaaaatgca ggtctttcag     1920

aatctagaac taggcataac cttacataat actaggaaaa ttatgagaaa ggggaaattt     1980

ttggttaaat aagagtaagg ttcaaacaca agcagtacat gttctgtttc attatgctcg     2040

atagaaggct tttttttcac ttataaggcc tgattggtcc tacccagctt aacggggtgg     2100

ggtttttttg tttgttcaga cagtctgttc ttttgtaaac atttttagtt ggaaaaacag     2160

catctgcatt ttccccatcc tctacgtttt agagaggaat cttgtttttg tgtgcaacat     2220

aagaaaatta tgaaaactaa tagccaaaaa acctttgaga ttgcattaaa gagaagggat     2280

aaaggaccag caataatacc ttgtaagttg cttttgtttg taaaatctga gcttatagtt     2340

ttccttagtg agtaaattca taaggatggg aacatttaaa ttaagttaat gggcctttaa     2400

aaaaaaaaaa aggaaacact catacctgta gttggaggat gaatactgga gacgggttac     2460

caatgtcagg ttatactaaa actaaatcag aaagtctgaa tgtagcacat aatggttctc     2520

ttctgttgtc caaggctgta aaatggacag ccttgtcaca cctccccggt gctgttttac     2580

aacgtgaggg tagacgctgt cagtaaccca gagggaccag gccttcctag gttttctagg     2640

cagtcagctg ttaaccactc acttagtaaa tgtcataact acacctgctc caggaccaat     2700

cagtgaaacc tgctcggaat taaaggcttc ctctgggtgc ctgctgaaca actgagctca     2760

tgtcatgggc atgtggtggt ttctctgttg cctgaaagag ccattaaagt cagtcgtgcg     2820

tgaagcatct ctcttctaaa ggatgtgtat ttccataaat gctttctgag gatccggtac     2880

aaaatgattt cccaaagttc tgaagtgcct tgagaacatg tgggtccgag tgttataaca     2940

gactcctccc ccgggtcacc ttttgcctgg tcatcctgtt agagtacatc tttggaaatc     3000

cagggtaata ttctctttca gagatgctca ttgtgtaact ctgtgtaggg agatagtcac     3060

tttaaacagc tcaaagtagc tagctaaagg agtagcctta aatacctaaa agatgacaga     3120

agcatagccc ttaacaaatc ttcagcttgt ctctcagtat ttcccaatca tgaaaatccc     3180

ttgctatgtc tttcctacta gaaatgttct agaatcgctg gacggtgggg tcagagggca     3240

gtcggtattt aggccgtgag cttcccatac tactgcaggt ccaactcctg gcaaccgcgg     3300

gctcaaggca ggtcattgga atccacgttt tggccacagt agttgtagga ttgcttttct     3360

gtatcataat tttagaatgc tcttaaaatc ttgaggaaga gtttttattt tttatttatt     3420

tttgagatgg agtctctgtt gcccaggctg cagtgcagtg gtgccatctc agctcactgc     3480

aacctccacc tcccaggttc aagcgattct cctgcctcag ccacctgagt agctgggagt     3540

acaggcatgt ggcaccatgc ctggctaatt tttgtatttt taatagagtt gagatttcac     3600

catgatggtc aggctggtct cgaactcctg acctcgtgat ccgcccgcct cggcccccca     3660

aagtgctggg attaacgggt gtgagccacg gcgcccagcc caggaagagt ttttaaatta     3720

gagctctgtt taattatacc actgggaaat catggttacg cttcaggcat attcttcccc     3780

agagtactac ttacatttta aatttcattt tgtaaagtta aatgtcagca ttccctttaa     3840

aagtgtccat tgttctttga aagtagacgt ttcagtcatt cttttcaaac aagtgtttgt     3900

gtaccttttg ccaagctgtg ggcatcgtgt gtgagtacag ggtgctcagc tcttccaccg     3960

tcattttgaa ttgttcacat gggtaattgg tcatggaaat gatcagattg accttgattg     4020

actgtcaggc atggctttgt ttctggtttc aatctgttct cgttccttgt accggattat     4080

tctactcctg caatgaaccc tgttgacacc ggatttagct cttgtcggcc ttcgtgggga     4140

gctgtttgtg ttaatatgag ctactgcatg taattcttaa actgggcttg tcacattgta     4200

ttgtattttt gtgatctgta atgaaaagaa tctgtactgc aagtaaaacc tactccccaa     4260

aaatgtgtgg ctttgggtct gcattaaacg ctgtagtcca tgttcatgcc aaaaatggct     4320

gggaacgttt gctttattta cattcagtca gcgttgcttt cagatcacac tttatccaca     4380

caggaaagcc agtcagccta taatgaagta gttattaaaa taaatgtaat gaatatgtct     4440

acaaagtata gtttagtggt ttattttgct aaaatgcaca tatatttgat ataatttagt     4500

ttgagaagtt cagctagttt ttctcctttg tttgactttg tcaatttcta tctggttttt     4560

aagggtctga gcttagcttg tgcatgcaag gttttgggtt tttttatttt ttttttgagc     4620

acagcttttc accttttaat ttgttgggta tttttctctt aataagagaa atattggcca     4680

tcgattttta catataatac aagtgtgttt ttccagtaca ttggttcctg tcccctctct     4740

gtgaactgtt tgagtattgg aacagtatgt cttcaataat tcaatgttac tttgagatac     4800

atgtgttaat atacccttag ttattcttga aataaaacca gtctcttacg cttgcagtgg     4860

agaaagg                                                               4867


<210> 3408
<211> 2175
<212> DNA
<213> Homo sapiens

<400> 3408
ggcgagcgcg gcggccgggg tggtagtggc agtgttcgtg tgctcaggtc tgaatcgccg       60

agggaggagg cggtggagga agaggtggcg gcggtggcgg tggtcgtagc ggtggcggag      120

gaggcgggta cgaatcagct gcgggcggag acatggccaa catcgcggtg cagcgaatca      180

agcgggagtt caaggaggtg ctgaagagcg aggagacgag caaaaatcaa attaaagtag      240

atcttgtaga tgagaatttt acagaattaa gaggagaaat agcaggacct ccagacacac      300

catatgaagg aggaagatac caactagaga taaaaatacc agaaacatac ccatttaatc      360

cccctaaggt ccggtttatc actaaaatat ggcatcctaa tattagttcc gtcacagggg      420

ctatttgttt ggatatcctg aaagatcaat gggcagctgc aatgactctc cgcacggtat      480

tattgtcatt gcaagcacta ttggcagctg cagagccaga tgatccacag gatgctgtag      540

tagcaaatca gaatgcagta atagtggcct tgtcttcaaa atcatgggat gtagagactg      600

caacagaatt gcttctgagt aactgaggca tagagagctg ctgatatagt caagcttgcc      660

tcttcttgag gagcaccaac atctgttatt tttaggattc tgcatagatt tcttttaaac      720

tggcattctt gcctaatgat gttatctagg caccattgga gactgaaaaa aaaaaatccc      780

tgctctgtaa ataaagctaa ttaaacgtct gtgtaaattt aaaaagggga aatactttaa      840

ttttttttct taatagtgta aaaattccct gagctaagct aaaaccatgg aagaaacatg      900

ctactttagt gtttagcagt gtaccaagac tagcaagagt ttgcttcagg attttgttga      960

ataattaaga taatattttg agtgtgtcag ggccattcaa attgttggtg ttgcatcaca     1020

gctaccttaa ctgtttttaa catggatcct ctgtgcctgt gaatttactt gcatgcttgt     1080

acttgacttc ttaggatggg tagctgaaaa gaccaccatt ttaagcattt gagaattctt     1140

aaatatgaaa tttattcaga attgaagatg gtgacctatt cagagccttt ttgtccttgt     1200

caacagactg ggacagtgtc tgattccccc ttcacccccc ccacccccgc cttgccacac     1260

acagctaata ttctaatggt aaatttctct gtatcaggtg gggaaatgtg ctgaaggaca     1320

gtatgtatcc cttgcttcat ttttaggtcg taggtttgga atgtcttgtc ccagttcttc     1380

aaacactctt aaatttttct taagtaatgt aaaaatggaa ctgccaattt tatttctctt     1440

gcaaaaatag taaatacttg atgttacatt attcccaggt ttaatgaaag aacccaactt     1500

agtttttcag tgaatttgac acctattttt tagtgatgaa atttttcttt gagaactggc     1560

aaggatgcag tcagctgttt gcagttttta gcctgatttt ggggtctata gagattgctt     1620

tattggatac ttcaagtcat tcttgcttgc acttccccta ttgacacatg aaagctgtgt     1680

tggtgtttta ttgtacatac ttcagatgca cataggaata gaagtgtgtt ataaatctag     1740

ctttctttat gatgtttctg ataatacgag aattgaaaac tttaccttct cttgtacata     1800

gtcagactat ttgtattaaa tttacatttc attctaagtt caaaagtttg aaaattatta     1860

gttttgcaag atcacacact aatgtaacca ttttatgaag gttgaagtgg atttatgcag     1920

gcagttctat atatagaaat acaattcttt ttaaattttt aggaccaata caaaataaca     1980

aaaatgtaat ggaatcagac tgaattaaag taaggctgta tattgaaagt catattataa     2040

aaggtttgct ttctttaagt gttatttatc ttaaattata atcgttaaat gtttggaaga     2100

taatttttga atcataacgt cagcataact tcatttgact tctcaataat cttgatacta     2160

gaagcaataa aagaa                                                      2175


<210> 3409
<211> 820
<212> DNA
<213> Homo sapiens

<400> 3409
gagtccctgc ttcgcagagc accggacttg gagtcagaga gacctggctg cgaatcccgg       60

ctccgccact ttctagcgct gtgaccttgg cacaacagct ccagctggca gcatcacttc      120

ccgccaattt atccaacttc tgccaaggct ctgaaatgcc aacaacgtcg aggcctgcac      180

ttgatgtcaa gggtggcacc tcacctgcga aggaggatgc caaccaagag atgagctccg      240

tggcctactc caaccttgcg gtgaaagatc gcaaagcagt ggccattctg cactaccctg      300

gggtagcctc aaatggaacc aaggccagtg gggctcccac tagttcctcg ggatctccaa      360

taggctctcc tacaaccacc cctcccacta aacccccatc cttcaacctg caccccgccc      420

ctcacttgct ggctagtatg cacctgcaga aacttaatag ccagtatcag gggatggctg      480

ctgccactcc aggccaaccc ggggaggcag gacccctgca aaactgggac tttggggccc      540

aggcgggagg ggcagaatca ctctctcctt ctgctggtgc ccagagccct gctatcatcg      600

attcggaccc agtggatgag gaagtgctga tgtcgctggt ggtggaactg gggttggacc      660

gagccaatga gcttccggag ctgtggctgg ggcagaatga gtttgacttc actgcggact      720

ttccatctag ctgctaatgc caagtgtccc taaagatgga ggaataaagc caccaattct      780

gttgtaaata aaaataaagt tacttacaaa gagacgggcc                            820


<210> 3410
<211> 3007
<212> DNA
<213> Homo sapiens

<400> 3410
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg tggatggcca gggtacctgg     1200

ggactcaggc tgctgccagt tctgctcacc accatccgtg cttggcacag aagtagctgc     1260

atagaaaggg cactggattt gaagtcagaa gacctgggtt cttgaaccag cctgtcaacc     1320

agttgtatga ctttaaacaa ggcatctcac ctcttttcat cttgttttct tccaataatg     1380

ttagagttca tgtaatcaca ttctctagaa ccatttagtt tgtgttaact atgaaccaag     1440

cagtgtggtg gccactggtg acttgaaaat atagagaaaa aaaaaacctg ctctatatct     1500

gaaagagctc ttgggaagac agagaaacat aaagaggaaa ttacagcaca gtgtggtggg     1560

tgttacggga agtccaaccc cagcattatg ggagttcagg ggaaggggca tagcccagcc     1620

tggaaggaga gggtgagtgg gggatggctt tctgaaaagg gtggtctaaa ggatgcctat     1680

ggtcaatagg gaaaagaggg gaagaagcat cttaagaaga ggaaacagca gagaactggc     1740

tggatgacct gtgactctgg agcactgggt tgtctccatt gtcattatgg gcagatgtgt     1800

gccatcccca gccgacgcca ctcactgcct ccttcctcct ggtgttgcca cttctgggtg     1860

agattaaggt gcagggcctg ggggcaggag gacataaggt atagccataa atcataaccc     1920

agggaccaca ctcaacccta gggaaattgt cttcctgatc agttgattac catctgaggt     1980

caagaaatga gatagtggga gcaaatgggt cacaaatagc tcagctgtgg gctcagaaac     2040

tgctaggtaa aagaattcca gaaggaggcc agggcataag ttggatgacc tatgaacttt     2100

agtctaaaga attgagacta ccgtaattga gactactgta gtgacatctg agaaatggga     2160

tggaatagtg accatgtttt attttcttgt tcttgtcact attgtatttt attttgcata     2220

atcatgccct tcactgacag tctccttaac atcatctgtt tactctgctc agtgtaaact     2280

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2340

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2400

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     2460

gagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     2520

aaaatacaga cacacacaag tgcctatata atgataaaac atatccaaag cacccaaacc     2580

tgtgattcca gaaaagtaga tcctattttt gtttattttt attggcttta gctgtgtctt     2640

ttgaaaggac tattatcctc taaaatgtat gtgtatgaag atcctggctt gcagctcggg     2700

agctttacac accttgtgtc actttatctt ggtaacgagc caagatcatg caaccagttc     2760

atccatgtct gacccaagag ctcttaactg ctatgctgca ctgcctcatt cagagataga     2820

tgcctgcatg ggtcctggcg attattttaa tgctggctac acccccacag gtgacttgga     2880

ttcagaaata caatttatat ttcttctttt taaattgttt tattttattt ttcttttaat     2940

agttatatgt cagtgagaac aatttatatg tcttacactg agaaataaaa ctgctcataa     3000

gtgaaaa                                                               3007


<210> 3411
<211> 762
<212> DNA
<213> Homo sapiens

<400> 3411
gcggcggcgg cagcggcagc ggcagcggcg ctgagttttg tctcccgggc cgtctgggcg       60

cgcgcgggtg tcccagactc acttttcccc ttcgtctttc tctccctttc tgtctttctg      120

tgtctcctcc aagaatgaaa tatgactgag gactctcaga gaaactttcg ttcagtatat      180

tatgagaaag tggggtttcg tggagttgaa gaaaagaaat cattagaaat tctcctaaaa      240

gatgaccgtc tgggaatctt gcctccacac cacgagtccc atgccaaggt gatgatgtat      300

cgtaaggagc agtacttgga tgtccttcat gccctgaaag tcgttcgctt tgttagtgat      360

gccacacctc aggctgaagt ctatctccgc atgtatcagc tggagtctgg gaagttacct      420

cgaagtccct cttttccact ggagccagat gatgaagtgt ttcttgccat agctaaagcc      480

atggaggaaa tggtggaaga tagtgtcgac tgttactgga tcacccgacg ctttgtgaac      540

caattaaata ccaagtaccg ggattccttg ccccagttgc caaaagcgtt tgaacaatac      600

ttgaatctgg aagatggcag actgctgact catctgagga tgtgttccgc ggcgcccaaa      660

cttccttatg atctctggtt caagaggtgc tttgcgggat gtttgcctga atccagttta      720

cagagggttt gggataaagt tgtgagtgga tcctgtaaga tc                         762


<210> 3412
<211> 1737
<212> DNA
<213> Homo sapiens

<400> 3412
acgtgatgcg ccgggagcgt catcgcctcc tccctcccca agatggcgtc cttgctgcag       60

tcggaccggg ttctctatct agtccaggga gaaaagaagg ttcgggcccc gctctcgcaa      120

ctctacttct gccgctattg tagcgaactg cggtcgctgg aatgtgtgtc tcacgaggtg      180

gactcccatt attgtcccag ttgtttagaa aatatgccat cggctgaagc caaactaaaa      240

aagaatagat gtgccaattg ttttgactgt cctggctgca tgcacaccct ctctactcgg      300

gccacgagca tctccacaca gcttccagat gacccagcca agaccaccat gaagaaagcc      360

tattacctgg catgtggatt ttgtcgctgg acgtctagag atgtgggcat ggcagacaaa      420

tctgtagcta gtggcggttg gcaggaacct gaaaatcctc acacacaacg gatgaacaaa      480

ttgattgaat attaccagca gcttgctcag aaagagaagg ttgagcgaga tcgcaagaaa      540

ctggcacgac gtagaaacta tatgcctctg gctttttcgc aacatactat tcatgtagtg      600

gacaaatatg gtcttggaac caggcttcag cgaccacgag ctggtgcatc catcagtacc      660

cttgccggac tttcccttaa agaaggagag gatcagaaag agataaagat tgagccagct      720

caggctgtgg atgaagtgga acctctacct gaagactatt atacaagacc agtaaattta      780

acagaggtaa caacccttca gcagcgtctg ttacagcctg acttccagcc agtctgtgct      840

tcacagctct atcctcgcca caaacatctt ctgatcaaac ggtccctgcg ctgccgtaaa      900

tgtgaacata atttgagcaa gccagaattt aacccaacgt caatcaaatt caaaatccag      960

ctggtcgctg tcaattatat tccagaagtg agaatcatgt caattcccaa ccttcgctac     1020

atgaaggaga gccaggtcct cctgactctt acaaatccag ttgagaacct cacccatgtg     1080

actctcttcg agtgtgagga gggggaccct gatgatatca acagcactgc taaggtggtg     1140

gtgcctccca aagagctcgt tttagctggc aaggatgcag cagcagagta cgatgagttg     1200

gcagaacctc aagactttca ggacgatcct gacattatag ccttcagaaa ggccaacaaa     1260

gtgggtattt tcatcaaagt tacaccacag cgtgaggagg gtgaagtgac cgtgtgcttc     1320

aagatgaagc atgattttaa aaacctggca gcccccattc gccccattga agaaagtgac     1380

cagggaacag aagtcatctg gctcacccag catgtggaac ttagcttggg cccacttctt     1440

ccttaaaagg ttccactgga gggcagatcc caaaggacag tatcaccgta aacctgcgtt     1500

aaaatgtgga agctgctgct tcattaggcc ttgtttataa cgatgtaccc atgcactacg     1560

gaattctatt gctaagaaag tgggagcata ggcaaggcat tgggaacaca gggtagctgc     1620

tgttgctctt gctctcaccc ctgttgacac cagtaagtct gtgtctccct cactgaaccc     1680

tgcacgttga gtaacagcag cataattcca tcctaggaaa ggggatgggt gttcctt        1737


<210> 3413
<211> 684
<212> DNA
<213> Homo sapiens

<400> 3413
gtacgggagc tggaggctga gcttgatgca gagcagaaga agcacgccga ggcccttaag       60

ggcgtgcgca agcatgagcg ccgtgtcaag gagctcgcat accaggccga ggaggacagg      120

aagaacctgg ctcgcatgca ggacctggtg gacaagctgc agagcaaggt caagagctac      180

aagcgccagt ttgaggaggc ggtgagtgcg ctggggcctg gacacctgga ccgggcaccc      240

cagctctgcc ccagggtctg tggccaggag cagcaggcca acaccaacct ggccaagtat      300

cgcaaggccc agcacgagct ggatgatgcg gaggagcggg cagacatggc ggaaacccag      360

gccaacaagc tgcgggcacg gacccgggac gccctgggcc ccaagctatc cctttctcct      420

cagcacaagg agtgacggcc tgaccccctg ggctctaaag aggaatgtct gctgttgcac      480

atctggctga ggccacctgc cccgatcctg ccatctctgc atcgccccct gctgccttca      540

gccttccctg ggccctgaat aaacaccaca gccagtttcc ttctcattct tttctttggg      600

gttcaggagg aaaaacacag tcctagggac aaaagccagg tccacagcag tcatttttaa      660

aataaagtta tttaatagtc tcca                                             684


<210> 3414
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 3414
acggggcggg gacgagctgt cgcgctggtt gctcgtgcag gagcgggacc cggaacagac       60

cgccgtgaga gaggaggggc gccggccggg attcgcggcc cggagctcgg gaccggagtc      120

aggaatggag agaagggtaa tggtgttacc tcttattgtg gaaacctgtt gagatcacag      180

agaatatact gacggcataa aagggcagaa ccatagcagg gtgcggttgc ttcattccag      240

cctcgcagtc acctctgtgc cctgctggtt gtcttcccag cgctgctgta gttgccttcc      300

atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg aacggagacc      360

tctctgaact aagaatacca tggccacgtc agccccacta cggagcctgg aagaggaggt      420

gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact gtggccacgt      480

cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc ccgtctgccc      540

actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac tggccagcct      600

ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag aggtgacccg      660

ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact actactgtga      720

ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca ggccccacac      780

ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga accacctgag      840

taccctaagg agagacagag acaaaattca gggcttccag gcaaagggag aagctgatat      900

cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg agtttgagca      960

gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg cgaagctgga     1020

gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg agcttgcccg     1080

gctggccctg gtcatctccg aactggaggg caaggcgcag cagc                      1124


<210> 3415
<211> 4115
<212> DNA
<213> Homo sapiens

<400> 3415
ccgcctgcac cgccgccgcg ccccattggg ccgggtgctg gggcatcccg ggcgctgggt       60

gccccgagcg gctacgacga gtcccaggtg gggccgggct ccaggcccgc gggggagcgg      120

agccgtgcgc cgcaggcggg ctccgtgacg ccgggtgggg aacgccgggc cggtggcggg      180

acttccgcca cgggactcgg aaggggccgc gccgccgctg ctgggagttg tagtccggcc      240

gtggttgggg gagccgcggc tcatgcgcgg tgcacagagg cttgtttcac atctgtaaca      300

acaggaggag gcccagcctc gtgatgagga atagcaagga gagaattcag ctccagttca      360

aaagcctaca aaatctgaga ctgtcattgc ttttataagg attccagctt tccctcctgg      420

ccagaaatgt tcagcctgga ctcattcaga aaagatcggg cccagcacag gcagcgtcag      480

tgcaaacttc ccccaccccg ccttccaccc atgtgtgtca accctacccc aggagggacc      540

atctctcgag gctgaacgtt aacatttcca acatggcagc ttctagggac ctattaaaag      600

agttcccaca gcccaaaaat cttctcaaca gtgtgattgg aagagccctc ggcatctcac      660

atgcaaaaga caaactagtc tacgtgcaca caaatggacc gaagaaaaag aaagtcacac      720

tgcacataaa atggcccaag agcgtggagg tagaaggcta tggcagcaag aagatcgatg      780

ctgagcggca ggctgcagct gcagcctgcc agctgttcaa gggttggggt ctgctaggtc      840

cccggaatga gttgtttgac gcagccaaat accgagtgct agctgatcgc tttggctccc      900

ctgccgacag ctggtggcgt ccggaaccca ccatgccccc tacttcctgg cggcagctga      960

atccagagag tattcgacca gggggacctg ggggcctatc ccgctcttta ggccgggaag     1020

aagaggagga cgaggaggaa gagctagaag aagggaccat agatgttacc gacttcttgt     1080

ccatgaccca gcaggattcc cacgctccac tcagggactc aagggggagt tcctttgaga     1140

tgacagatga cgacagtgcc attagggctc tgacccagtt tccacttccc aagaaccttc     1200

tggccaaggt gattcagatt gcaacgtcat cctccacagc taagaacctc atgcagttcc     1260

atactgtggg caccaagacc aagctgtcta cactcaccct gctctggccc tgccccatga     1320

cctttgttgc caaagggcgc cgcaaagcag aggctgagaa taaggcggca gccttggcct     1380

gcaagaaact gaagagcctg ggcctggtgg acaggaacaa cgaaccgctt acacacgcca     1440

tgtataacct ggcctctttg cgtgagctgg gtgagaccca gcgccgacca tgcaccatcc     1500

aggtgcccga gcccatcctc cgcaagatag agaccttcct gaaccattac cctgtggaga     1560

gttcatggat cgccccagaa ctccggctgc agagtgatga catcttgccc ttgggcaagg     1620

actcagggcc tctgagtgac cctatcacag gcaagcccta tgtgcccctg ttggaagcag     1680

aggaggtacg tctcagccag agtctgctag aactgtggcg gcggcgaggg ccggtctggc     1740

aggaggcccc ccagctacct gtggacccac atcgggacac catcctcaac gccattgagc     1800

agcacccggt ggtggtcatc tctggggaca cgggctgtgg gaagaccacg cgcatccccc     1860

agctgttgct ggagcgctat gtgaccgagg gccgaggtgc ccgctgcaat gttatcatca     1920

cccaacctcg ccgcatctct gctgtgtctg tggcacagcg ggtcagccac gaactgggcc     1980

cctccctgcg ccggaatgtg ggcttccagg tgcggttgga aagtaagccc ccatcccgag     2040

gcggggccct gctcttctgc actgtgggta tcctgctgcg taagctgcag agcaacccca     2100

gcctggaggg cgtgagccac gtcatcgtgg atgaggtgca tgagcgggac gtgaacacag     2160

actttctgct gatcctgctc aagggcctgc agcggctcaa cccggccctg cggctggtgc     2220

tcatgagtgc cacaggggac aatgagcgct tctcccgata ctttggtggc tgccccgtca     2280

tcaaggtgcc tggcttcatg tacccagtca aggagcacta cctagaggac atcctggcca     2340

agttgggcaa gcaccagtac ctgcaccggc accggcacca tgagtctgag gatgaatgcg     2400

cactcgattt ggaccttgtg actgatctgg ttctgcacat cgatgctcgc ggggaaccag     2460

gtgggatcct gtgcttcctg cctgggtggc aggagatcaa aggagtgcag cagcgcctcc     2520

aggaggccct gggcatgcac gagagcaagt acctcatcct gccagtgcac tccaacatcc     2580

ccatgatgga tcagaaggcc atattccagc agcctccagt tggggtgcgc aagattgtct     2640

tggccaccaa cattgctgag acttccatca caatcaatga catcgtgcat gtggtggaca     2700

gtgggctgca caaggaagaa cgctatgacc tgaagaccaa ggtgtcctgc ctggagacag     2760

tgtgggtatc aagagccaat gtgatccagc gccggggccg ggcgggccgc tgccagtccg     2820

gctttgccta ccacttgttc cctcgaagcc ggctggagaa aatggtccct ttccaagtgc     2880

cagagatcct gcgcacacct cttgagaacc tggtgctgca agcgaaaatc cacatgcctg     2940

agaagacggc ggtggagttc ctgtccaagg ctgtggacag tccaaacatc aaggcagtgg     3000

acgaggctgt gatcttgctc caggagatcg gggtgctgga ccagcgggag tacctgacta     3060

ccctggggca gcgcctggct cacatctcca ccgacccccg gttggccaag gccattgtgt     3120

tggctgccat cttccgttgc ctgcacccac tactggtggt cgtttcctgc ctcacccggg     3180

accccttcag cagcagccta cagaaccggg cagaggtgga caaggtgaaa gcactgttga     3240

gccatgacag cggcagtgac cacctggcct ttgtgcgggc tgtcgccggc tgggaggagg     3300

tgctgcgttg gcaggaccgc agctcccggg agaattacct ggaggaaaac ctgctgtacg     3360

cacccagcct gcgcttcatc cacggactca tcaagcagtt ctcagagaac atttatgagg     3420

ccttcctggt ggggaagccc tcggactgca ccctggcctc cgcccagtgc aacgagtaca     3480

gtgaggagga ggagctggtg aagggcgtgc tgatggccgg cctctacccc aacctcatcc     3540

aggtgaggca gggcaaggtc acccggcagg ggaagttcaa gcccaacagc gtcacatata     3600

ggaccaaatc aggcaacatc ctgctgcaca agtcgaccat taacagggag gccacacggt     3660

tacggagccg atggctgacg tatttcatgg cagtcaagtc caatggcagc gtcttcgtcc     3720

gggactcctc tcaggtgcac ccgctagctg tgctgctgct gaccgacggg gacgtgcaca     3780

tccgtgatga cgggcgccgg gccaccatct cactgagcga cagtgacctg ctgcggctgg     3840

agggtgactc gcgtaccgtg cggctgctga aggagctgcg gcgggccctg ggccgcatgg     3900

tggagcggag cctgcgcagc gagctggctg cacttccccc cagcgtacag gaggagcacg     3960

ggcagctgct tgcgctactg gcagagctgc tgcgaggacc ctgtggcagc tttgatgtgc     4020

gcaagacagc tgacgactga gccctgcttc tgctggggct gtgtacagag tgcaaatgtt     4080

tatttaaaat aaagttctat ttatcccttg tgacc                                4115


<210> 3416
<211> 759
<212> DNA
<213> Homo sapiens

<400> 3416
agtgggcgtg gaagcagcca gggtcatcgc caaggcctta gagaagaagt cggagttgaa       60

gcgctgccac tggagtgaca tgttcacggg aaggctgcgg accgagatcc caccagccct      120

gatctcacta ggggaaggac tcatcacagc tggggctcag ctggtggagc tggacttaag      180

cgacaacgca ttcgggcccg acggtgtgca aggcttcgag gccctgctca agagctcagc      240

ctgcttcacc ctgcaggaac tcaagctcaa caactgtggc atgggcattg gcggcggcaa      300

ggtcatcggg accctggagg aggtccacat gccacagaat gggatcaacc accctggcat      360

cactgccctg gcccaggctt tcgctgtcaa ccccctgctg cgggtcatca acctgaatga      420

caacaccttc actgagaagg gcgccgtggc catggccgag accttgaaga ccttgcggca      480

ggtggaggtg attaattttg gggactgcct ggtgcgctcc aagggtgcag ttgccattgc      540

agatgccatc cgcggcggcc tgcccaagct aaaggagctg aacttgtcat tctgtgaaat      600

caagagggat gctgccctgg ctgttgctga ggccatggca gacaaagctg agctggagaa      660

gctggacctg aatggcaaca ccctgggaga agaaggctgt gaacagcttc aggaggtgct      720

ggagggcttc aacatggcca aggtgctggc gtccctcag                             759


<210> 3417
<211> 8807
<212> DNA
<213> Homo sapiens

<400> 3417
gacgtcggcg gtgacaggcc ctgggactct gggaataccc agcttcctcc ccgcaacccg       60

gtgaaagcca acgcaatgtt cggtgcgggg gacgaggacg acaccgattt cctctcgccg      120

agcggcggtg ccagattggc ctcacttttt ggactggatc aggcagctgc tggccatgga      180

aatgaatttt tccagtacac agccccaaaa cagcctaaga aaggccaggg aacggcagca      240

acaggaaatc aggcaacacc aaaaacagca ccagccacca tgagcactcc cacaatactg      300

gtcgcaacag cagtccatgc atatcgatac acaaatggtc aatatgtaaa gcagggcaaa      360

tttggtgctg cagttctggg gaaccacaca gccagagagt ataggattct tctttatatc      420

agtcaacaac agccagttac ggttgctagg attcatgtga actttgagct aatggttcgg      480

cccaataact atagcacctt ttatgatgac cagagacaga actggtccat catgtttgag      540

tcggaaaagg ctgctgtgga gttcaataag caggtgtgca ttgctaagtg caacagtacc      600

tcttccctgg atgcagtgct ctcccaggac ctcattgtgg cagacggccc tgctgtagaa      660

gttggagatt ctttggaagt ggcctatacc ggctggctct ttcagaatca tgtgctgggc      720

caggttttcg actccactgc taacaaagat aagttgcttc gcttgaagtt aggatcagga      780

aaagtcatca agggctggga ggatggaatg ctgggcatga aaaaaggagg aaagcgattg      840

cttattgtcc ctccagcctg tgctgttggc tcagaagggg taataggctg gactcaagca      900

acggactcga tcctggtgtt cgaggtggag gttaggcggg tgaagtttgc cagagattct      960

ggctctgatg gtcacagtgt tagttcccgc gattctgcag ctccgtctcc catccctggt     1020

gctgacaacc tctctgctga tcctgttgtg tcaccaccca catcaatacc tttcaaatca     1080

ggggagccag ctcttcgtac caaatctaac tccctcagtg aacaacttgc aataaataca     1140

agtcccgatg cagtcaaagc caagttgatc tctcggatgg ctaaaatggg ccagcccatg     1200

ctgcccatcc ttccaccaca gctggattcc aatgattcag aaatcgaaga tgtgaacact     1260

ctgcaaggag gtgggcagcc tgtggtgact ccgtccgtcc agccctctct tcatccggcc     1320

catccagcgt taccacagat gacctcacag gcacctcagc catctgttac tgggctccag     1380

gcaccttctg ctgccttaat gcaagtgtca tctctcgatt cccactcagc tgtatctgga     1440

aatgcccaat cctttcagcc ctatgcaggt atgcaagcct acgcttatcc ccaggcatct     1500

gccgtcacct cccagctgca gcccgttcgg cctttgtacc cagcaccgct ctctcagcct     1560

ccccatttcc aaggatcagg tgatatggct tcatttctca tgactgaagc ccggcaacat     1620

aacactgaaa ttcgaatggc agtcagcaaa gtggctgata aaatggatca tctcatgact     1680

aaggttgaag agttacagaa acatagtgct ggcaattcca tgcttattcc tagcatgtca     1740

gttacaatgg aaacaagcat gattatgagc aacatccagc gaatcattca ggaaaatgaa     1800

agattgaagc aagagatcct tgaaaagagc aatcggatag aagaacagaa tgacaagatt     1860

agtgaactaa ttgaacgaaa tcagaggtat gttgagcaga gtaacctgat gatggagaag     1920

aggaacaact cacttcagac agccacagaa aacacacagg caagagtatt gcatgctgaa     1980

caagagaagg ccaaggtgac agaggagtta gcagcggcca ctgcacaggt ctctcatctg     2040

cagctgaaaa tgactgctca ccaaaaaaag gaaacagagc tgcagatgca gctgacagaa     2100

agcctgaagg agacagatct tctcaggggc cagctcacca aagtgcaggc aaagctctca     2160

gagctccaag aaacctctga gcaagcacag tccaaattca aaagtgaaaa gcagaaccgg     2220

aaacaactgg aactcaaggt gacatccctg gaggaggaac tgactgacct tcgagttgag     2280

aaggagtcct tggaaaagaa cctctcagaa aggaaaaaga agtcagctca agagcgttct     2340

caggccgagg aggagataga tgaaattcgc aagtcatacc aggaggaatt ggacaaactt     2400

cgacagctct tgaaaaagac tcgagtgtcc acagaccaag cagctgcaga gcagctgtct     2460

ttagtacagg ctgagctaca gacccagtgg gaagcaaaat gtgaacattt gttggcctcc     2520

gccaaggatg agcacctgca gcagtaccag gaggtgtgcg cacagagaga tgcctaccag     2580

cagaagctgg tacaacttca ggaaaagtgt ttagccctcc aggcccaaat cacagctctc     2640

accaagcaaa atgaacagca catcaaggaa ctagagaaga acaagtccca gatgtctggg     2700

gttgaagctg ctgcatctga cccctcagag aaggtcaaga agatcatgaa ccaggtgttc     2760

cagtccttac ggagagagtt tgagctggag gaatcttaca atggcaggac cattctggga     2820

accatcatga atacgatcaa gatggtgact cttcagctgt taaaccaaca ggagcaagag     2880

aaggaagaga gcagcagtga agaagaagaa gaaaaagcag aagagcggcc acgaagacct     2940

tcccaggagc agtcagcctc agccagttct gggcagcctc aagcacccct gaatagggag     3000

aggccagagt cccccatggt gccctcagag caggtggtcg aggaagctgt cccgttgcct     3060

cctcaggccc tcaccacttc ccaggatgga cacagaagga aaggggactc agaagctgag     3120

gcactctcag agataaaaga tggttccctt ccacccgaac tgtcttgcat cccatcccac     3180

agagttctag ggcccccgac ttcaattcca cctgagcccc taggccctgt atccatggac     3240

tctgagtgtg aggagtcact tgctgccagc ccaatggcag ctaagcccga caacccatca     3300

ggaaaggtct gtgtcaggga agtagcacca gatggcccac tacaagaaag ctccacaaga     3360

ctgtccctga cttcagaccc cgaggagggg gacccactgg ccttagggcc tgaaagccca     3420

ggagagcctc agcctccaca gctcaagaaa gatgatgtca ctagctccac cggtccccac     3480

aaggagctgt caagcacaga ggcaggttcc acagttgcag gagcagccct cagacccagc     3540

catcattccc agcgttccag tctctctggg gatgaagagg atgaactgtt taaaggggca     3600

actctgaaag ctctgaggcc caaagcacag cctgaggagg aggatgaaga cgaggtgagc     3660

atgaagggac gcccgccccc aacgcccctt tttggagatg atgatgatga cgatgacatt     3720

gactggctgg gatgaagacc caggaaactg gtgcaaaggt ttctctgcaa cccttcccta     3780

agcatgattt tgcacagcca accctgggtc taggcgaacc acagggtgag gtcaaggtga     3840

gcattctggg aacaatattt gggctcagag ggtgggttgg ccaccttctg agccccaccc     3900

ccgccagacc tggtgaagag gatcataacc ctgtcttcaa gaacactggg atttcagcag     3960

caagttggaa gaaggactgg taggttcccc tccaagccag tcacctgtaa gagtcctgtc     4020

ctctgccaga ctttttaatc tcttcattaa ctctcagact gacctgggag ccctcctcta     4080

cctgaatcca gtgctcaact gtgccccggc aacaagacct gggctgaggt ctccctggta     4140

gaactaaggg agattacacc atctaaatcc cagtgcagtc aacagcctgg cctatagtcc     4200

tgggacatgt atcttcttct ttgccttaaa tctgatacaa gaggtcaatg actttgaaaa     4260

taaaactaaa ataaatgtct ataatgaaac ttgacccaag cccttggaga aaaattgagt     4320

ttggttccaa gggctgtctg tgctcttttg ggaatctaag ggtaggagtc ttacagatct     4380

gggtcagtta atgtgcacaa aacgttgtgg catatttact ccctttgata cctaaccctg     4440

gaacttttag gctttcaaag aaagtcacca ctgtagtcct agctcatccc tggggcatga     4500

tggttctgtg aggaccagtc cagtcatcct cttgctcctg caggcttagt cctgcagtct     4560

aggaagccat gcaaagaagg tgagagggtc ccttctttcc attgttcatg gcacctgagg     4620

gattcttcac tttgagagca gcttccattc ccttagaact catgggacca ggacttatgc     4680

agagaacagt agtgagaaaa tacttgtggt cattttcttg attccaggat cttccaaaga     4740

ttatgcaatc agtctttaaa aaaacagaat aattaatttt aataaaaaat gtttcttgat     4800

tttaaatgtt ttaaaagata ggacccaaaa ttccacttca tctggcctgg catcatcctt     4860

gcaggctttg gatatgtctc ccgtgtgcgg acctgggagg cagtgagaac taattatttc     4920

tttgttgctt aacaaaaggc ggtgctgttt ggcactttca cagactggct tatctccagc     4980

aaccactgca gaagacagtg ttatcaccat tttatagagg agaaaactga gacttagaga     5040

ggtaaagtaa tttgcccaaa gttacatatc taggaagcct cagcacaaga attcaaatcc     5100

tggccatctg attccagagc ctgggctctt ggccagcaca gcctgactgt cactggttgg     5160

gggaaggggc ggtgatgctt ttagaaacag gcttcttgag acaccaggca gctttccagt     5220

tccctgcaaa catgggggaa tgccctgatc agtcctaaag gtgtgacata gtctactttc     5280

tagggcagtt atttcttatt gtaaattaac tagtggctat tatatttgct tctgcccgca     5340

gggagagaag atgctgagta attgtgccaa cacaggtgct taaagtccgt gtgacagtta     5400

cttttcttat agcatgtact caattaatac ttgttacatg aatgaagaat gacttgactt     5460

gcctcagttg gcattctggg gtgtctacct gggtgcagca tttcagggct gggtttccct     5520

gagcagagtt gtctttgtag cagatggatg gactctgtcc tcagacaggc ttataaagag     5580

tactaccagt tctattagcc ccactcagcc cctgcagttg ttacaagggt tcatgtgctt     5640

tctgttggaa ttaggagaac agaacagtca tagactattt aaaaatatat atttactaaa     5700

atgtatttgt ttgtttttaa ttcccaaagc ttacaaccat cttttcatct aatctgtgag     5760

gtatttagta tacagcagtg attttctctc tttccttttt tataaagtga agaggttcaa     5820

ctatccagag agtcccatct aactcaaaaa atgtaatggc tttggttgga ttgcatcttc     5880

agtcagtacc tgcccatggc ttaatcagta ttttaagtga atgaatcatg tttccccact     5940

agatcattac gagtaagcag taagtaataa atagagaata ttaagtattg aacattatta     6000

gatgcagctt tttgttctgc atagaagaaa gatgaggata aaggagggca ttgaggccac     6060

gaagagcttc ccagacaccc acggccatca gatcatcttc ttcctgcagg cagtgccttc     6120

tggtggaagg agctcagtct atcagagaat aaaccaggag cctgaaagca gtcctgtgtc     6180

tctgccttta atcagctgtc acttattctc tccccaagaa agggaaatag gtctcagcag     6240

tttctgccat ccatcatgaa tcaatgaaat catttcatta aaaatttttt tgtatgaatg     6300

tgcaaaattg ccaactagga gttcaatggg aaaaataaaa aaaacttagt ttgtcaacat     6360

gatccataga cgagatgatc ttcatgtgtt ccaaaggcag aaaggtgaga aaaaggatct     6420

agcttggtct ctgtccctca aagacagaag aggtcaggaa gtccaatggg cgatgctcct     6480

gtagataagg cacaaagcag gagagctgag ggtgtccagg ttccatgccc tgcatcacca     6540

agaacccttc tccctggctt gaaatctttg gaaattcctg gtttgagtca cagagaagca     6600

ttgtcatggg ctcagtaacc ctgccacccc tgttatctcc attctccctt tggtcacagc     6660

agctgtctta agacacaaga ccatgcctgg gccctacgta ggctggctga gaaggaaggt     6720

tgctgcaatg gcttccgaac tccagggagc aagtgctggc ttcagctcaa agtttccagg     6780

ggctgggaat aaggtggagg aatagccatc agaagaaagg gcagttggaa gtatagtgtc     6840

tggaagaggg ggctccatgt ccctccagcc tcagtgcctg cacgttcctc accagctaag     6900

ctgtgctgag aagtgggtaa gctaggtagt agcccacagc agagcccaag accacaccaa     6960

ggaaaatcca ggtgttgtag gacattacgg ccagcatgat gaagtagccg atgaccacct     7020

ggatgacatg gattagagac tggccaaagt gacacaaata ccacctagat aaaaaggaga     7080

agcaagttaa tcctggtaat gagctggtaa tgaggaagct gggagtagat atcagggagt     7140

agaaagctgt tgagttacgt gacccgattg atttataact tgtatgctta acccaggagt     7200

gatttctttc tgcccctccc acccccgccc ccagaaaaaa ctcgagattt atttttaaag     7260

agacatatct tcactacatt tggtttcaag cttcctggca tcctaggcaa aggggaaaat     7320

gagggtatct ataatctgtc tttctgataa ggaataagag aaaatcatca gtaaggcata     7380

tttcccccct gaatctactt cgggaggcag tatgacaatg gaaagaaaaa gcatggtctt     7440

aggtgacatt atcagttcct agacctgcca ctaactaaaa gtggcctaga caaatgtctt     7500

aacctctctg aacgtaagat tccttatcag taaaacagga atgagaatac ttcccttgca     7560

gtgcagttgt gaagatctga gacacccatg tagggtggct agtgatggag cgggcaggct     7620

tattaagcac aggtgaggct ggggctggac agagggcaga acagggaccc taaatggttg     7680

cctgattcga gtgggaaggg aggagaggag agcttgtcat cctcctccca ccaagtggga     7740

tacattgctt caggacagct gcagatcccc tcctggatat gggagcctag tgacccatgg     7800

aactggtgag atttggggga gggtgggtgg ccacctcatt tgctagatag gggcctgcac     7860

ctgaagatca ctgttcccta aagaaagcct tctgagcctc tcaagtggct ggctgttcac     7920

agagtgcttt ggcctgggca tcaggagaca tgagctctag ttcacttggc tatgtgtagc     7980

cactttggca agtcctggtc cttccctggg cctcgctgtc ctctctgtga agtggggcta     8040

atgctgtctg ggccagcctg tctctcaggg tgaatgtgag gcttctgccc ctttcccata     8100

cccactgcct gtacctgtgg tgggttctgc caacagggaa tgaatctgag cctgcagagt     8160

ccccgtctgt ctctgcgatg gtctgctggc tgatggaggt tggcaggttc accagtacct     8220

ggttgagcag cttggctttg ccaaccttga tgccttcata cagtacagcc agaagcagga     8280

gcaccaacac cgaaagggcc atgcctgtca aaggaggcag agttgtggag acctggccag     8340

gccagcactg tttcccttcc agcacctcca cctgttcatg gaatccactc catccacctc     8400

tatcctgcac cttcttcccc acccttgctg agttccgaac ttcttcactg tcttcaccag     8460

acttttctta gctggagtgt ggctttgaga tcaggaagag aagccacctg aaaaatccag     8520

gggctgaggg tgaagaagcc acgtaccatt accccaccca ctcccccagc aggctgcaca     8580

aatctgtcgt gacttcttgt taagtgatga gtactgcaag gtcctattta tatgtaagta     8640

tgcaaaaaat gtctggaagg aaagataaat agcacaagag taatagttat ctcagcaaag     8700

taggatacag gtggttttta tgttcttgcc taactttcta aggtttcttt tatatatatt     8760

acttttataa taggggaaaa acccaataaa ttattttacc aaaacta                   8807


<210> 3418
<211> 1728
<212> DNA
<213> Homo sapiens

<400> 3418
tgaggtttgg tctctgttgt cacaacattc agtacaatct gctgcccagg acctggacat       60

tgacagataa aatgaagtgg gaagaatatg aagaactgct tcattatgct atagtgactc      120

caaatattga accctgtgct tcacagtcat ctcatcctaa gggagaattg gtgccagatg      180

tcagaatttc tacaattcat gatattcttc atagtcaagg aaataactct gaagtaagag      240

aaactgcaat agaagttgga aaaggatgtg atttccatat ttcaagtcat tcaaagacag      300

atgagtcatc accagtgtta tcgccaagga agccttctca cccagtcatg gattttttca      360

gttcacatct tttagctgac tcttcctcac cagcaacaaa ttctagtcat acagatgccc      420

atgaaatact tgtgagcgat tttcttgttt ctgatgaaaa ccttcagaag atggaaaatg      480

tgcttgatct ttggagttca ggtcttaaga caaacatcat atctgaacta agtaaatgga      540

gacttaattt tattgactgg caccgaatgg aaatgagaaa agagaaagaa aaacatgcag      600

cacatttaaa acaactgtgt aatcagatca atgaattgaa ggagctgcaa aaaacctttg      660

aaatctccat tgggagaaaa gatgaggtga tttctagctt gtctcatgcc ataggcaagc      720

aaaaggaaaa gatagagttg atgagaacat tcttccactg gcgaatcggc catgtcagag      780

ccagacagga tgtttatgaa ggtaaactag ctgaccagta ctaccagaga actttactga      840

agaaagtctg gaaagtctgg cgttccgtag tgcaaaagca gtggaaagat gtggtagaaa      900

gagcttgtca agcaagagct gaagaagttt gtatccagat ttccaatgat tatgaagcca      960

aagttgctat gttatctgga gctttggaaa atgcaaaagc tgagattcaa agaatgcaac     1020

atgaaaaaga gcactttgaa gattccatga aaaaagcttt catgaggggt gtatgtgcat     1080

taaatcttga agccatgact atatttcaaa acagaaatga tgcagggata gactccacaa     1140

ataataaaaa ggaagagtat ggtcctggtg ttcaaggaaa agaacattct gctcatttgg     1200

atccttcagc tcctccgatg cccttaccag ttacatcacc actgctgcca tccccaccag     1260

ccgccgtcgg aggagccagc gcgactgccg ttccctcagc tgcttcgatg acttctacca     1320

gggctgcttc cgcatcttct gttcacgttc ctgtttctgc tcttggtgca ggatctgcag     1380

ctactgctgc atcagaagaa atgtatgtgc caagagttgt aacctctgca caacagaaag     1440

caggaagaac tattacagcc cggatcacag gaagatgtga ttttgcttca aaaaatagaa     1500

ttagcagcag tttagctata atgggagttt ctcctcccat gagctcagtt gttgtggaaa     1560

aacatcatcc agtcacagtg caaaccattc ctcaagcaac tgcagcaaaa tatccccgga     1620

ccattcatcc tgaaagtagt acctcagctt ccagatcact tggaaccaga tcagctcaca     1680

cccagtctct cacaagtgtt cattccataa aagtggttga ctaaagtg                  1728


<210> 3419
<211> 402
<212> DNA
<213> Homo sapiens

<400> 3419
atgagtccca gccagatgat catgcccaat gtcatggaga tgatcgcagc cctgggcccc       60

ggcccgtccc cctatcccct cccgcctccc ccagggggca ccaactccaa cgactacagc      120

agccaaggca acaactacca aggccatggc aactttgact tcccccacgg gaaccctgga      180

gggacatcca tgaatgactt catgcacggg cccccccagc tctcccaccc cccggacatg      240

cccaacaaca tggccgccct cgagaaaccc ctcagccacc ccatgcagga aactctcctt      300

cccgaactca caaatcctga cgagctcctg tcttatctgg acccccccga cctgccgagc      360

aatagtaacg atgacctcct gtctctattt gagaacaact ga                         402


<210> 3420
<211> 2587
<212> DNA
<213> Homo sapiens

<400> 3420
cccatctcta cgaaaaatac aaaaattagc caagtatggt ggccggcgcc tgtaatccca       60

gctactcggg agactgaggc agagaactgc ttgaacctgg gaggcagagg ttgcagtgat      120

ccgagatcgc gtcactgcac tccagcgtgg gcgacagagc gagactccgt ttcagaaaag      180

aaaaaaaaaa aaaaaaaaaa gggagtcggg gtggagctct cattggctcg ttgcatgtga      240

gtgtccctac ggcctagaaa tacaagagaa gcacatcgga acgggctgga aatccaccca      300

gttaactaga gggctttgaa ccttttatta acttggaggt tgactctcct gtcaactcga      360

ttcccttttg gctgtttggc agggtcagtg agacatcccc tgggtcgctc gaccccgtag      420

gacggttcag ggagccctcc aggtcttcgt ttctcctctt ccccgcacag tgctgttatc      480

cagctggggg atccaacgca cacttaaggc tccagcaaag tggctccgct gccggatggg      540

agtgccccag tgtgctggat gaagctggcg catgcaccat gtcatcatgt gtctctagcc      600

agcccagcag caaccgggcc gccccccagg atgagctggg gggcaggggc agcagcagca      660

gcgaaagcca gaagccctgt gaggccctgc ggggcctctc atccttgagc atccacctgg      720

gcatggagtc cttcattgtg gtcaccgagt gtgagccggg ctgtgctgtg gacctcggct      780

tggcgcggga ccggcccctg gaggccgatg gccaagaggt cccccttgac acctccgggt      840

cccaggcccg gccccacctc tccggtcgca agctgtctct gcaagagcgg tcccagggtg      900

ggctggcagc cggtggcagc ctggacatga acggacgctg catctgcccg tccctgccct      960

actcacccgt cagctccccg cagtcctcgc ctcggctgcc ccggcggccg acagtggagt     1020

ctcaccacgt ctccatcacg ggtatgcagg actgtgtgca gctgaatcag tataccctga     1080

aggatgaaat tggaaagggc tcctatggtg tcgtcaagtt ggcctacaat gaaaatgaca     1140

atacctacta tgcaatgaag gtgctgtcca aaaagaagct gatccggcag gccggctttc     1200

cacgtcgccc tccaccccga ggcacccggc cagctcctgg aggctgcatc cagcccaggg     1260

gccccattga gcaggtgtac caggaaattg ccatcctcaa gaagctggac caccccaatg     1320

tggtgaagct ggtggaggtc ctggatgacc ccaatgagga ccatctgtac atggtgttcg     1380

aactggtcaa ccaagggccc gtgatggaag tgcccaccct caaaccactc tctgaagacc     1440

aggcccgttt ctacttccag gatctgatca aaggcatcga gtacttacac taccagaaga     1500

tcatccaccg tgacatcaaa ccttccaacc tcctggtcgg agaagatggg cacatcaaga     1560

tcgctgactt tggtgtgagc aatgaattca agggcagtga cgcgctcctc tccaacaccg     1620

tgggcacgcc cgccttcatg gcacccgagt cgctctctga gacccgcaag atcttctctg     1680

ggaaggcctt ggatgtttgg gccatgggtg tgacactata ctgctttgtc tttggccagt     1740

gcccattcat ggacgagcgg atcatgtgtt tacacagtaa gatcaagagt caggccctgg     1800

aatttccaga ccagcccgac atagctgagg acttgaagga cctgatcacc cgtatgctgg     1860

acaagaaccc cgagtcgagg atcgtggtgc cggaaatcaa gatcctggtg aagaccatga     1920

tacgtaaacg ctcctttggg aacccattcg agggcagccg gcgggaggaa cgctcactgt     1980

cagcgcctgg aaacttgctc accaaaaaac caaccaggga atgtgagtcc ctgtctgagc     2040

tcaagaccta gaaaataagt ccccttcctg cctgttgcaa agtaacgtaa gagttccctc     2100

acccgagtgg atgcagacct tcttgctgtc agccaccctt ccttcataca catagccagc     2160

ccaggtgacc agaacctccc aggacagatg aggctttgtg tccttatgag actgggagaa     2220

cctgctgggc acccctgctg caggtgctgt ggtgggtggg gaccccactg cccttcccac     2280

tgagcacatc atggctacct gacttggtgg gagctccagg cagtcacttc tgtttcttaa     2340

acatagcttt actgaggtac aattcacata ccatgtaatt cacccacggg aagtgtatga     2400

ttcagtggtt tctaatacag acttctgcag ccattaccac cgtcaacttt acgacatttt     2460

catcagccca agaagacacc ctacactcct tagctgtccc catccaactc ccccacccca     2520

gtaaccactc agaataggta tggatttgcc tattctggac gtttcgtata aatggcgtca     2580

tacacta                                                               2587


<210> 3421
<211> 2042
<212> DNA
<213> Homo sapiens

<400> 3421
ggaagttgag cggcggcaag aaataatggc ggcagctacg ggggatcctg gactctctaa       60

actgcagttt gcccctttta gtagtgcctt ggatgttggg ttttggcatg agttgaccca      120

gaagaagctg aacgagtatc ggctggatga agctcccaag gacattaagg gttattacta      180

caatggtgac tctgctgggc tgccagctcg cttaacattg gagttcagtg cttttgacat      240

gagtgctccc accccagccc gttgctgccc agctattgga acactgtata acaccaacac      300

actcgagtct ttcaagactg cagataagaa gctccttttg gaacaagcag caaatgagat      360

atgggaatcc ataaaatcag gcactgctct tgaaaaccct gtactcctca acaagttcct      420

cctcttgaca tttgcaattg aagcactaga gtgtgcatat gataatcttt gtcaaacaga      480

aggagtcaca gctcttcctt acttcttaat caagtatgat gagaacatgg tgctggtttc      540

cttgcttaaa cactacagtg atttcttcca aggtcaaagg acgaagataa caattggtgt      600

atatgatccc tgtaacttag cccagtaccc tggatggcct ttgaggaatt ttttggtcct      660

agcagcccac agatggagta gcagtttcca gtctgttgaa gttgtttgct tccgtgaccg      720

taccatgcag ggggcgagag acgttgccca cagcatcatc ttcgaagtga agcttccaga      780

aatggcattt agcccagatt gtcctaaagc agttggatgg gaaaagaacc agaaaggagg      840

catgggacca aggatggtga acctcagtga atgtatggac cctaaaaggt tagctgagtc      900

atcagtggat ctaaatctca aactgatgtg ttggagattg gttcctactt tagacttgga      960

caaggttgtg tctgtcaaat gtctgctgct tggagccggc accttgggtt gcaatgtagc     1020

taggacgttg atgggttggg gcgtgagaca catcacattt gtggacaatg ccaagatctc     1080

ctactccaat cctgtgaggc agcctctcta tgagtttgaa gattgcctag ggggtggtaa     1140

gcccaaggct ctggcagcag cggaccggct ccagaaaata ttccccggtg tgaatgccag     1200

aggattcaac atgagcatac ctatgcctgg gcatccagtg aacttctcca gtgtcactct     1260

ggagcaagcc cgcagagatg tggagcaact ggagcagctc atcgaaagcc atgatgtcgt     1320

cttcctattg atggacacca gggagagccg gtggcttcct gccgtcattg ctgcaagcaa     1380

gagaaagctg gtcatcaatg ctgctttggg atttgacaca tttgttgtca tgagacatgg     1440

tctgaagaaa ccaaagcagc aaggagctgg ggacttgtgt ccaaaccacc ctgtggcatc     1500

tgctgacctc ctgggctcat cgctttttgc caacatccct ggttacaagc ttggctgcta     1560

cttctgcaat gatgtggtgg ccccaggaga ttcaaccaga gaccggacct tggaccagca     1620

gtgcactgtg agtcgtccag gactggccgt gattgcagga gccctggccg tggaattgat     1680

ggtatctgtt ttgcagcatc cagaaggggg ctatgccatt gccagcagca gtgacgatcg     1740

gatgaatgag cctccaacct ctcttgggct tgtgcctcac cagatccggg gatttctttc     1800

acggtttgat aatgtccttc ccgtcagcct ggcatttgac aaatgtacag cttgttcttc     1860

caaaatctgg gacatgagcg atgatgagac catctgagat ggccccgctg tggggctgac     1920

ttctccccgg ccgcctgctg aggagctctc catcgccaga gcaggactgc tgaccccagg     1980

cctggtgatt ctgggcccct cctccatacc ccgaggtctg ggattccccc ctctgctgcc     2040

ca                                                                    2042


<210> 3422
<211> 965
<212> DNA
<213> Homo sapiens

<400> 3422
cggagaaatg tggagctgat taatgaagaa gctgccatgt tcgatagtct tctcatggac       60

tcttatgtga gctctaccac tggggagagt gtgatcacaa gagagatggt ggagatgctc      120

ttttctgatg attctgacct gcagttagca accacacaga aattccggaa actgctctcc      180

aaagagccta gtcctccaat agatgaagtt atcaacactc caagagtggt ggatcggttc      240

gtggagtttc tgaagaggaa tgagaattgt acattacagg cagtctgggc actgggaaac      300

atagctggag atagctctgt ttgccgagat tacgtcttga actgttccat ccttaatcct      360

ttgttaacac tccttaccaa gtccacacga ctgacgatga cacggaatgc agtctgggcc      420

ctgtcaaatc tctgccgagg gaaaaaccca cccccagagt ttgcaaaggt ctctccttgt      480

ttgcctgtac tgtctcgcct actcttcagc agcgactcgg acttgctggc agatgcttgc      540

tgggcccttt cttatctgtc tgatggcccc aatgagaaga tccaggcagt catagactcc      600

ggagtctgcc ggagattggt agagctgctg atgcacaatg attacaaagt ggcttctcct      660

gccctgagag ccgtgggtaa catcgtcact ggggatgaca tccagaccca ggtcattctt      720

aactgttcag ccctaccttg ccttctccac ttgttgagca gtcccaagga gtcaatccgg      780

aaggaagctt gctggactat ttcaaatatt actgctggca acagggctca aatacaggct      840

gttatagatg caaatatctt ccctgtgttg atcgaaatcc ttcagaaagc agagtttcgt      900

acaaggaaag aggcagcctg ggccatcacc aatgccacat caggaggaac ccctgagcag      960

atcag                                                                  965


<210> 3423
<211> 1842
<212> DNA
<213> Homo sapiens

<400> 3423
ggagacgccc gcccggtgcc cgccctgggc ccggcgggtg ccccctgccc gccgcctgac       60

gcaatccgag gcgcccttgc tgcatgccgg cgctggagaa acctcccctg ccgttgcatc      120

actcctgcca ggtttgccac agaggtggag ctgaaccaat cagcgggcgc gctgggcccg      180

cggcgcggtt aagtgagaag cagaatccga agttgattgg ccaaaagggg atttgcccca      240

ccccaatcac cgcggcagct ggccgcggtg ggcgtggtct cccggcaaga aggtttaaag      300

ggcgcctcca tggggggcgc tcagctggag ctaccgagcg gtgccaggcc aggtgtgtgc      360

gtccgtcggt ctttccgtgc ccacgccgga gaccagcccc ggaggccgcc tgggcctatc      420

cctgtgccag gcaccatgaa gcaggagtct gcagccccga acaccccgcc cacctcgcag      480

tcccctacgc cgtccgctca gttcccccga aacgacggcg accctcaagc gctgtggatt      540

ttcgggtacg gctccctggt gtggaggccc gacttcgcct acagcgacag ccgtgtgggc      600

ttcgtgcgcg gctacagccg ccgtttctgg cagggagaca ccttccatcg gggcagcgac      660

aagatgcctg gccgtgtggt gacgctcctt gaagatcatg agggctgcac ttggggcgtg      720

gcataccaag tgcaagggga gcaggtaagc aaggccctga agtacctgaa tgtgcgagag      780

gcagtgcttg gtggctacga taccaaggag gtcaccttct atccccaaga tgctcctgac      840

caaccactga aggcattggc ctatgtggcc accccacaga accctggtta cctgggccct      900

gcgcctgaag aggccattgc cacgcagatc ctggcctgcc ggggcttctc cggccacaac      960

cttgaatact tgctgcgtct ggcagacttc atgcagctct gtgggcctca ggcgcaggac     1020

gagcacctgg cagccatcgt ggacgctgtg ggcaccatgt tgccctgctt ctgccccacc     1080

gagcaggctc tggcgctggt gtgaggggct gagcccctgc ggggagtgct catgtggaca     1140

tcagggccag acacccactc cagtgcacaa gacagacttg cgaccgcttg agcccactga     1200

gcagatatgg tgggtggctg gaggcttctc tttctcagtc cctgcctgtc tgccagcctg     1260

cagctctcct gcttgacact gacttactac ttgaaacttt atttattgca ccatgttggt     1320

gtggtgggca ggtggagggc ctgccctgga cacaggggcc ctgctgagca gtggccccat     1380

cctggaactt gaccagattc cccccagtgc tgctgctaac cccacaccac ccaggcctcc     1440

acctccccag ggagtctcca agagcctcga tcctctgctc actcagccca gccatccata     1500

gccctgggaa ttccacctgc caaggatccc agcaggctgg atgagggata gtagggcatg     1560

aggagaagga gccctgtaag gactgaggcc ccggccagcc cttctcctcc accagttccc     1620

cagagcagag ctggagctga tgcctggaca cagctgctga gcctggcctg ggcctcttac     1680

ccacttggtt gttttcttgt ccctctgtct gtctgtctat ctacttgtct gtctgggcca     1740

ctcctgcctg tgtgttggtc tattcctggg aagctcatca ctacaggccc tggcaacctt     1800

cccagtctgt cccatactgt tacccataaa actatctctt ta                        1842


<210> 3424
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 3424
acggggcggg gacgagctgt cgcgctggtt gctcgtgcag gagcgggacc cggaacagac       60

cgccgtgaga gaggaggggc gccggccggg attcgcggcc cggagctcgg gaccggagtc      120

aggaatggag agaagggtaa tggtgttacc tcttattgtg gaaacctgtt gagatcacag      180

agaatatact gacggcataa aagggcagaa ccatagcagg gtgcggttgc ttcattccag      240

cctcgcagtc acctctgtgc cctgctggtt gtcttcccag cgctgctgta gttgccttcc      300

atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg aacggagacc      360

tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg aagaggaggt      420

gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact gtggccacgt      480

cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc ccgtctgccc      540

actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac tggccagcct      600

ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag aggtgacccg      660

ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact actactgtga      720

ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca ggccccacac      780

ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga accacctgag      840

taccctaagg agagacagag acaaaattca gggcttccag gcaaagggag aagctgatat      900

cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg agtttgagca      960

gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg cgaagctgga     1020

gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg agcttgcccg     1080

gctggccctg gtcatctccg aactggaggg caaggcgcag cagc                      1124


<210> 3425
<211> 1070
<212> DNA
<213> Homo sapiens

<400> 3425
acgccttgac agcggctttc aacccccacc tcagcccagc aattcgtttg gagcatgtga       60

acaccttgag ccttgatgag ttccagtatg tggtatatta tgcagagcat tcagagcaaa      120

tactctctct ccgagcgctt aatccgaaca attgctgcca tccgttcctt cccacatgat      180

aatgtagagg acctcatcag agggggagca gatgtgaact gcactcatgg cacactgaag      240

cccttgcact gtgcctgtat ggtgtcagat gctgactgtg tggagttact tctggaaaaa      300

ggagccgagg tgaatgccct ggatgggtat aaccgaacag ccctccacta tgcagcagag      360

aaagatgagg cttgtgtgga ggtcctattg gagtatggtg caaaccccaa tgccctggat      420

tacaacaatg atacaccgct cagctgggct gccatgaagg gaaatcttga gagtgtcagc      480

atccttctgg attatggcgc agaggtcaga gtcatcaacc taataggcca gacacccatc      540

tcccgcctgg tggctctgct agtcagggga cttggaacag agaaagagga ctcttgcttt      600

gagctcctcc acagagctgt tggacacttt gaattgagga aaaatggcac catgccacga      660

gaggtggcca gagacccgca gctatgtgaa aaactgactg ttctgtgctc agctccagga      720

actctaaaaa cactcgctcg ctatgccgtg cgccgtagcc tgggactcca gtatctcccc      780

gatgcagtga agggccttcc actgccagct tctttgaagg aatacctgtt acttttagaa      840

tagccggaga agatgtttgc accatcgtgc aggcagctct gggtgaggtt gtccctgcag      900

tactccttgt cacagaaaac agaaaaacag ttgttcctgt tgtgtggttt atagatttcg      960

aagcaacatg tcacaacaat aacctccata gcacctcccc ttcccaaacc aaacaaccca     1020

acaaaaaaaa tccctcactt ttgttttctg tttattgctt acctggcttt                1070


<210> 3426
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3426
gagcctgttc agccccactg gttttactgc aaggaggtag aatacaaaca actgtggatg       60

ccttttagtg tgttcgactc tttgaatctt gaagaaatct ataattcagt tcagccagat      120

ccggagagcg tggttcttgg cacggatgga gggcgctacg atgtttacct ctatgaccga      180

ataaggaagg ctgcctactg ggaagaggag ccagccgaag tgagacgctg tacttggttt      240

tacaaggggg acacagatag tcgatttatt ccctatactg aggagttcag tgaaaaacta      300

gaggttattg ttcagttcca gccctcctca gtgccagatg aatggggcac cacgcaagat      360

ggacagacaa ggcccagggt tgtaaagcgt ggaattgatg ataaccttga tgaaattccc      420

gacggggaga tgcctcaagt tgaccatttg gtgtttgtgg tgcatggcat tggacctgtg      480

tgtgacttac gctttaggag cattattgag tgtgtggatg attttagggt ggtttctctc      540

aaattgctgc ggacacattt caagaaatct ttagatgacg gg                         582


<210> 3427
<211> 1103
<212> DNA
<213> Homo sapiens

<400> 3427
cgcggctcca gggccacgtt ccagggtcgg gtttggtgga ttcctcagtc cctgccgccg       60

cggggcgccc tgggatagcg gcggggcctc ctgaacagat ctcggcccct ttccaaacac      120

tcctgatgcc tcatttgcct ctcgcttctt ttcgaccacc attttggggg ctgaggcact      180

cacggggcct ccccaggttt cactccgttt ctacacagtc ggagccccat ggatctccca      240

tctcccggag gaaccgtgaa gccaaacaga agcgcctgcg agagaagcag gctactctgg      300

aggctgagat agcaggggag agcaagtcac ctgcagaatc cattaaggcc tggaggccta      360

aggagttagt attgtatgaa atccctacga aacccggtga aaagaaagat gtctctgggc      420

ccctgcctcc tgcatacagc ccccgatatg ttgaggctgc ctggtacccg tggtgggtac      480

gagagggctt cttcaaacca gaatatcagg cccggctgcc ccaagctaca ggggagacct      540

tttccatgtg tatcccacct cccaatgtca ctggctccct gcacattggc cacgcactca      600

cggtggccat acaggatgcc ctcgtgcgct ggcaccggat gcgtggggat caagtgctgt      660

gggtccctgg ttcagatcat gcaggaattg ctacacaagc tgtggtggag aaacaactgt      720

ggaaggaacg gggagtgagg agacatgagc tgagccggga ggccttcctt agggaggtgt      780

ggcagtggaa ggaggcgaaa ggtggagaga tctgtgagca gctgcgagct ctgggtgcct      840

ccctggactg ggatcgagag tgttttacca tggatgttgg ctcctcagtg gctgtgactg      900

aagcttttgt gcggctctac aaggcggggt tgctgtaccg gaaccatcag cttgtcaact      960

ggtcatgtgc tttaagatca gccatctcgg acattgaggt ggagaaccgg cccctgcctg     1020

gccacacaca gcttcgactg cctggctgcc ccacccccgt gtcttttggc ctcctatttt     1080

ctgttgcctt ccccgtggat gga                                             1103


<210> 3428
<211> 1397
<212> DNA
<213> Homo sapiens

<400> 3428
agtggcgcta gcggcggacc cggctgggca gttccttccc cagaaggaga gattcctctg       60

ccatggagtc ctacgatgtg atcgccaacc agcctgtcgt gatcgacaac tgtgggccga      120

cccaagcacg ttcgtgtcat ggcaggagcc cttgaaggcg acatcttcat tggccccaaa      180

gctgaggagc accgagggct gctttcaatc cgctatccca tggagcatgg catcgtcaag      240

gattggaacg acatggaacg catttggcaa tatgtctatt ctaaggacca gctgcagact      300

ttctcagagg agcatcctgt gctcctgact gaggcgcctt taaacccacg aaaaaaccgg      360

gaacgagctg ccgaagtttt cttcgagacc ttcaatgtgc ccgctctttt catctccatg      420

caagctgtac tcagccttta cgctacaggc aggaccacag gggtggtgct ggattctggg      480

gatggagtca cccatgctgt gcccatctat gagggctttg ccatgcccca ctccatcatg      540

cgcatcgaca tcgcgggccg ggacgtctct cgcttcctgc gcctctacct gcgtaaggag      600

ggctacgact tccactcatc ctctgagttt gagattgtca aggccataaa agaaagagcc      660

tgttacctat ccataaaccc ccaaaaggat gagacgctag agacagagaa agctcagtac      720

tacctgcctg atggcagcac cattgagatt ggtccttccc gattccgggc ccctgagttg      780

ctcttcaggc cagatttgat tggagaggag agtgaaggca tccacgaggt cctggtgttc      840

gccattcaga agtcagacat ggacctgcgg cgcacgcttt tctctaacat tgtcctctca      900

ggaggctcta ccctgttcaa aggttttggt gacaggctcc tgagtgaagt gaagaaacta      960

gctccaaaag atgtgaagat caggatatct gcacctcagg agagactgta ttccacgtgg     1020

attgggggct ccatccttgc ctccctggac acctttaaga agatgtgggt ctccaaaaag     1080

gaatatgagg aagacggtgc ccgatccatc cacagaaaaa ccttctaatg tcgggacatc     1140

atcttcacct ctctctgaag ttaactccac tttaaaactc gctttcttga gtcggagtgt     1200

ttgcgaggaa ctgcctgtgt gtgagtgcgt gtgtggatat gagtgtgtgt gcacatgcga     1260

gtgccgtgtg gccctgggac cctgggccca gaaaggacga tgaactacct gcagtggtga     1320

tggcctgagg cctggggttg accactaact ggctcctgac agggaagagc gctggcagag     1380

gctgtgctcc ctcctca                                                    1397


<210> 3429
<211> 665
<212> DNA
<213> Homo sapiens

<400> 3429
gtgaaggtga gcgcctgggt cggcccgcgg gcttcctccg gccgcgctcg gattgagggc       60

cgggcggagg tgccgccctt gagagcagcc ggttgtcgat gccgctcccc tcagggacgg      120

ctccgggcgg gaagctctcg aggctcctcc cgctgcgggt cggcgctcgc cctcgctctc      180

ctcgccctcc gccccggccc cggccccgcg cccgccatgg agaagactga gctgatccag      240

aaggccaagc tggccgagca ggccgagcgc tacgacgaca tggccacctg catgaaggca      300

gtgaccgagc agggcgccga gctgtccaac gaggagcgca acctgctctc cgtggcctac      360

aagaacgtgg tcgggggccg caggtccgcc tggagggtca tctctagcat cgagcagaag      420

accgacacct ccgacaagaa gttgcagctg attaaggact atcgggagaa agtggagtcc      480

gagctgagat ccatctgcac cacggtgctg gaattgttgg ataaatattt aatagccaat      540

gcaactaatc cagagagtaa ggtcttctat ctgaaaatga agggtgatta cttccggtac      600

cttgctgaag ttgcgtgtgg tgatgatcga aaacaaacga tagataattc ccaaggagct      660

tacca                                                                  665


<210> 3430
<211> 1323
<212> DNA
<213> Homo sapiens

<400> 3430
agatacttgc cttcatgttt tggggctagt ccctagttcc tacttgtcag cccgggtgta       60

actccacacc acccctgtgg ctctccaccc tttcagatca agatgctgtc agatcggaaa      120

cgggagctgg agcatcgtct cagcgctact ttagaggaaa atgacctgct ccaagggacc      180

gtggaggagc tacaggaccg ggtgctaatc ctggagaggc agggccatga caaggaccta      240

cagctgcacc aaagccagct ggagcttcag gaggtgcgtc tctcctgccg acagctgcag      300

gtgaaggtgg aagaactcac tgaggagagg agtctgcaga gctctgccgc caccagcaca      360

tccctcctgt cagagatcga gcagagcatg gaggctgagg agctggagca ggagcgagag      420

caggtgacac tgctgagtgt ggagatgact gccctaaaag aggagagaga ccgactcaga      480

gtcacttctg aggacaagga gccaaaggag cagcttcaga aggccatcag ggaccgcgac      540

gaggccattg caaagaagaa tgctgtggag ctggaacttg ccaagtgcag gatggatatg      600

atgtctctga acagccagtt gctggatgcc attcagcaga aactgaacct ctcgcagcag      660

ctggaagctt ggcaggatga catgcacagg gtcattgacc ggcagctgat ggacacgcac      720

ctgaaagaac ggagccagcc ggctgctgcc ctctgcaggg gccacagcgc tgggcggggg      780

gatgagccca gcatcgctga aggcaaacga ctcttctcat tcttcaggaa aatttaagtt      840

gggaggagtc aggccaccaa agatgggtgg actggaggca gctggaaagg cggtgcaggc      900

aaggcctccc ctgcagcttg cacctcagca gctgccctgc ccctcatgct agggccccat      960

gggtccggga gggcctgctc cctttcgtcg gtggggatgg agacctagag gtgggggcct     1020

gccttggcca ctgaaggctt cccttggccc accgcctggc caagcccacg cctgggcttc     1080

tccaggacca cgtgcttgag cagggttagg ccacctccca gaggggcccc ttggtgttgg     1140

gctttgcagc tcacacccaa cagatcgcag cccaccccca ggcactgctg cctccttgat     1200

tttagcaaat ggggaacaga aggaatggag gcccttctct gcatgcctca ggaggcctga     1260

gccccagggg cctagacctg tgggggcagc gggccaggcc tgagcctcca ttccttcccc     1320

agc                                                                   1323


<210> 3431
<211> 711
<212> DNA
<213> Homo sapiens

<400> 3431
gcatatgctc tccaaagtgg gaatgtggga ttttgacatt ttcttgtttg atcgcttgac       60

aaatggaaac agcctggtaa cactgttgtg ccacctcttc aatacccatg gactcattca      120

ccatttcaag ttagatatgg tgaccttaca ccgattttta gtcatggttc aagaagatta      180

ccacagccaa aacccgtatc acaatgctgt tcacgcagcc gacgtcaccc aggccatgca      240

ctgctacctg aaagagccaa agcttgccag cttcctcacg cctctggaca tcatgcttgg      300

actgctggct gcagcagcac acgatgtgga ccacccaggg gtgaaccagc catttttgat      360

aaaaactaac caccatcttg caaacctata tcaggtaagg gagcccaacc tggagccagc      420

cacagtatgg tcaatcgcct taggcccggt gctcaagcct gaatcttgcc catggagaaa      480

gccttgtttt agggtcctag aagttcaaag acgaatgaaa cacaatctct gccctcaaaa      540

atttgttcaa actcagatgc tcaaaatgag caaaatccaa gcaaacttaa tcccagtttg      600

aaagaggttt gaggaattag ctcatgtcga tacaattgtt ttttaaaatc tctaaagagt      660

aaatacttgt gctgttcttt gtatccaaag accttactag aataaagtga g               711


<210> 3432
<211> 1770
<212> DNA
<213> Homo sapiens

<400> 3432
atggccatgg ccccaagccc ttccctggtg caggtgtaca ccagccccgc ggctgtggcc       60

gtgtgggaat ggcaggacgg gctgggcacc tggcacccct acagtgccac cgtctgcagc      120

ttcatcgagc agcagtttgt ccagcagaag ggccaacgtt ttgggcttgg gagcctggcc      180

cacagcatcc ccttgggcca ggcagacccc tcgctggccc cttacattat tgacctcccc      240

agctggaccc agttccgcca ggacaccggc accatgcggg ctgtgcggag acacctgttc      300

ccccagcact cagcccctgg ccgaggtgtc gtctgggagt ggctgagcga cgatggctcc      360

tggactgcct atgaagccag cgtctgtgac tatctggagc agcaggtggc caggggcaac      420

cagctcgtgg acttggcccc cctggggtac aactacactg tcaactacac cacccacacg      480

cagaccaaca agacttccag cttctgccgc agcgtgcggc gccaagcagg gccgccttac      540

ccggtgacca ccatcatcgc tccgccgggc cacacaggcg tcgcctgctc ttgccaccag      600

tgcctcagtg gcagcagaac tggccccgtg tcaggccgct accgccactc catgaccaac      660

ctccctgcat accccgtccc ccagcacccc ccacacagga ccgcttctgt gtttgggacc      720

caccaggcct ttgcaccgta caacaaaccc tcactctccg gggcccggtc tgcgcccagg      780

ctgaacacca ccaacgcctg gggcgcagct cctccttccc tggggagcca gcccctctac      840

cgctccagcc tctcccacct gggaccgcag cacctgcccc caggatcctc cacctccggt      900

gcagtcagtg cctccctccc cagcggtccc tcaagcagcc cagggagcgt ccctgccact      960

gtgcccatgc agatgccaaa gcccagcaga gtccagcagg cgctcgcagg agcgaccccg     1020

aagccagagc cagagccaga gcaggtcata aaaaactaca cggaagagct gaaagtgccc     1080

ccagatgagg actgcatcat ctgcatggag aagctgtcca cagcgtctgg atacagcgat     1140

gtgactgaca gcaaggcaat cgggtcccta gctgtgggcc acctcaccaa gtgcagccat     1200

gccttccacc tgctgtgcct cctggccatg tactgcaacg gcaataagga tggaagtctg     1260

cagtgtccct cctgcaaaac catctatgga gagaagacgg ggacccagcc ccagggaaag     1320

atggaggtat tacggttcca gatgtcgctc cccggccacg aggactgcgg gaccatcctc     1380

atagtttaca gcattcccca tggtatccag ggccctgagc accccaatcc cggaaagccg     1440

ttcactgcca gagggtttcc ccgccagtgc taccttccag acaacgccca gggccgcaag     1500

gtcctagagc tcctgaaggt ggcctggaag aggcggctca tcttcacagt gggcacgtcc     1560

agcaccacgg gtgagacgga caccgtggta tggaacgaga tccaccacaa gacagagatg     1620

gaccgcaaca ttacgggcca cggctatccc gaccccaact acctgcagaa cgtgctggct     1680

gagctggctg cccagggggt gaccgaggac tgcctggagc agcagtgacc tcgcacccca     1740

gcacgcccgc ctctggtggc caccccgctg                                      1770


<210> 3433
<211> 5073
<212> DNA
<213> Homo sapiens

<400> 3433
cgcgcacgca gggctagcct cgcccaggcc tcctccctca cgccggccgc aggacgggcg       60

cgcacgccaa gtgacgctcc gaggaggaag cgcagccccc ttcccctccc tcgctgcccc      120

tggcccagcg ggagcccccc ctccccccag tgcgcctgtg cggaggccct cttgattatg      180

tgtgccctct ccgggcgccc gcgttagcgg ccgggtggag gtggggaggg aagacgctga      240

ggaggaggag gaggcggagg aggcggtgga ggggaggtgg ggggaatcag caaggacatg      300

gctcctgact cctgtgcgga acgtgagtga ctgagcggca aagcccgaat ggtctctagc      360

gaccggcccg tgtcactgga ggacgaggtc tcccatagta tgaaggagat gattggaggc      420

tgttgcgttt gctcagacga gagaggctgg gccgagaacc cgctggttta ttgcgacggg      480

cacggctgca gcgtcgcggt gcatcaagct tgctatggca ttgttcaagt acccactgga      540

ccgtggtttt gcaggaaatg tgaatctcag gagagagcag ccagagtgag atgtgaactt      600

tgtccccata aggatggagc tttaaaaaga acagataatg ggggttgggc ccatgtggtt      660

tgtgccctgt atattccaga ggtacaattt gccaatgttt ccacaatgga accaattgtt      720

ttacagtctg ttccgcatga tcgttataat aagacttgct acatttgtga tgaacaagga      780

agagaaagca aagcagccac tggtgcttgc atgacatgta ataaacatgg atgtcgacag      840

gctttccatg taacatgcgc tcagtttgcc ggactgcttt gtgaagaaga aggtaatggt      900

gccgataatg tccaatactg tggctactgt aaataccatt ttagtaagct gaaaaagagc      960

aaacggggat ctaataggtc atatgatcaa agtttaagtg attcttcctc tcactctcag     1020

gataaacatc atgagaaaga gaaaaaaaaa tataaagaga aggacaaaca caaacagaaa     1080

cacaagaagc agccagaacc atcacctgca ttggttccat ccttgactgt tactacagaa     1140

aaaacttata caagcactag caacaactct atatctggat cattgaagcg cttggaagat     1200

actactgcac gatttacaaa tgcaaatttc caggaagtct ctgcacacac ctctagtgga     1260

aaagatgttt cagagactag agggtcagag ggcaaaggga agaaatcttc agctcacagc     1320

tcaggtcaaa ggggaagaaa gcctggtggt ggaagaaatc caggaacaac tgtgtcagca     1380

gctagccctt ttcctcaagg cagtttttca ggaactccag gcagtgtaaa gtcatcttct     1440

ggaagttcag tgcagtctcc ccaggatttc ctgagcttta cagactcaga tctgcgtaat     1500

gacagttact ctcactccca acagtcatca gcaaccaaag atgtacataa aggagagtct     1560

ggaagccagg aagggggggt aaatagtttt agtaccttaa ttggcctccc ttcaacctca     1620

gctgttactt cacagcctaa aagctttgaa aattcacctg gagatttggg taattccagc     1680

cttcctacag caggatataa gcgggctcaa acttctggca tagaagaaga aactgtaaag     1740

gaaaagaaaa ggaaaggaaa taaacaaagt aagcatgggc ctggcagacc caaaggaaac     1800

aaaaatcaag agaatgtttc tcatctctca gtttcttctg cttcaccaac atcatctgta     1860

gcatcagctg caggaagcat aacaagctct agtctgcaga aatctcctac attgctcagg     1920

aatggaagtt tacagagcct cagtgttggc tcatctccag ttggttcaga aatttccatg     1980

cagtatcggc atgatggagc ttgcccaaca actacgttct cagagttgct gaatgcaata     2040

cacaacggta tttataacag caatgatgta gcagtatcgt ttccaaatgt agtatctggc     2100

tcgggatcta gtactcctgt ctccagctct cacttacctc agcagtcttc tgggcatttg     2160

caacaagtag gagcgctctc tccctcagct gtgtcatctg cagcccctgc tgttgctaca     2220

actcaggcaa atactctatc tggatcttct ctcagtcagg caccatctca tatgtatggc     2280

aatagatcaa attcatcaat ggcagctctt atagctcagt ctgaaaacaa tcaaacagat     2340

caagatcttg gagacaatag ccgcaaccta gttggcagag gaagctcacc ccgaggaagt     2400

ctctcgccac gatcccctgt aagcagctta cagattcgct atgatcaacc aggcaacagc     2460

agtttggaaa atctgcctcc agtagcagcc agcatagaac agcttttgga gaggcagtgg     2520

agtgaaggac agcaattttt actagaacag ggtactccta gtgacatttt aggaatgctg     2580

aagtcattac accaacttca agttgaaaac cgaagattag aggaacaaat taaaaacttg     2640

actgccaaaa aggaacggct tcagttattg aatgcacagc tttcagtgcc ttttccaaca     2700

ataacagcaa atcctagtcc gtctcatcaa atacacacat tttcagcaca gactgctcct     2760

actactgatt ccttgaacag cagtaagagc cctcatatag gaaacagctt tttacctgat     2820

aattctcttc ctgtattaaa tcaggactta acctccagtg gacaaagtac cagcagctca     2880

tcagctcttt ctaccccacc tcctgctggg cagagtccgg ctcaacaagg ctcaggagtg     2940

agtggagttc agcaggtcaa tggcgtgaca gtgggggcac tagctagtgg aatgcagcct     3000

gtaacttcca ccattcctgc cgtgtctgca gtgggtggaa taattggagc tttgccaggt     3060

aaccaactgg caattaatgg cattgtagga gctttaaatg gggttatgca gactcctgtc     3120

acaatgtccc agaaccctac ccctctcacc cacacaaccg taccacctaa tgcaacacat     3180

ccaatgccag ctacactgac taacagtgcc tcaggactag gattactttc tgaccagcaa     3240

cgacaaatac ttattcatca acagcagttt cagcagttgt taaattctca acagctcaca     3300

ccagtacaca ggcaccccca cttcacacag ctaccaccaa cccatttctc accatccatg     3360

gagataatgc aagtcagaaa gtagcaagac ttagtgataa aactgggcct gtagctcaag     3420

agaaaagttg acacctgaga aacatctaga aattgcctat cctgctgttc tagcacttca     3480

tctggctgcc tttgcagtcc ttttactaca gctatgaaga aacgcaacaa gaaactcaat     3540

gcacaacaaa ggattaattg ctgcaaggac attcttgtaa ggctttgatt agttttcttg     3600

ttgctttgtt gcactgaaat ggaattccca tgcccctacc ccttacccca gttttttgaa     3660

catggaaaga aaatttaata actttttaaa gtgacataat ttacatgcaa tatgtttatc     3720

aactcaagaa tttaatatag ttggtacaca actagttttg tttataaatt ggagatgcaa     3780

atagcaaaac taaatacttg ctccatttac aaactacttg attttattgt acaagttgaa     3840

atatgctctt ttgtttgggt tacagtatgc ttgctctaag tcaaattcca aggaactaat     3900

ttcttctcct ggagttgcat tgattcagta ttacaaatat atagcacatc acctgggact     3960

tggcaatctt tgttaaaaaa aaatttcctt tctaatggga tttggccaat tttggtaatg     4020

aagttaggat ggtaatgtct gcatctgcta aaggtaattt tcttttgaga attgctttct     4080

ttagtgttaa gacctactca tattttgaag aaatcttgag ttaagtgagt tctgaggctg     4140

ctgggggaac cagatcaatt caaagctaaa tacttctttc agaaaggggc cactgtggaa     4200

agtgctggtg gggtttgccc ttgatcaagt gcctccattg tgctgcaagg gctgtagaca     4260

gcagggtggg acagtcagtc ctccgagcag caggaatcat cccgtcacct gcagccttcc     4320

catgcttccg cctttattca gaactttctg tgccactgta gatagctcag gcaaaactat     4380

tacctgggta tttatccact aatgagtcac aagaaaagga gtggatttgg taagaataga     4440

gatttgtttt atttaaacca cttcccatta ctgaccatta aaagctcacc actagagttc     4500

ctgaaacagg tgaaacctgt atgacagccc ttccactttg gggagccacg cttttgatgt     4560

gacagtaccg cagagtgatt cccccactga ggatgtcatc atcaaactct tctttggtgt     4620

gtgaattatt agtggaaaag acccagctgt aattagacct ccactgtgta cttagctgga     4680

agaacatgtt aattctgcaa tatgtttctt ggttaaacat tgcacagttc ttacctcatt     4740

tctgtaaata aagttttgtg aatctgtttt gtattgtgac aaattcataa gataacattg     4800

atattttgat ttgtaatatt tctaattggt agatttaatt gaaaagtaaa attaatttat     4860

ttttatatgt tcaggggaat tttaaagtca aatcttttgt agataattta aaaaatcagt     4920

gtggtttatt ttacttattt aacccactgg ttgttattct gtaacagttt gtataaatgg     4980

taaattttga atgtgttgtt attttaccta gatgtaaaat tccacatgta ttaaaatgta     5040

caaaatgttt tgttaataaa atttaataat gtt                                  5073


<210> 3434
<211> 3858
<212> DNA
<213> Homo sapiens

<400> 3434
ggaggtttca ctgcacaaca agatggcggc ggcggcggcg agcggagctg gcggggctgc       60

cggggccggg actgggggag ccgggcccgc gggccgcctg ctgcctccgc ccgcgccggg      120

gtccccagcc gcccccgctg ccgtgtcccc tgcggccggc cagccgcgtc ccccagcccc      180

ggcctcccgc ggacccatgc ccgcccgtat cggctactac gagatcgacc gcaccatcgg      240

caagggcaac ttcgcggtgg tcaagcgggc cacgcacctc gtcaccaagg ccaaggttgc      300

tatcaagatc atagataaga cccagctgga tgaagaaaac ttgaagaaga ttttccggga      360

agttcaaatt atgaagatgc tttgccaccc ccatatcatc aggctctacc aggttatgga      420

gacagaacgg atgatttatc tggtgacaga atatgctagt ggaggggaaa tatttgacca      480

cctggtggcc catggtagaa tggcagaaaa ggaggcacgt cggaagttca aacagatcgt      540

cacagctgtc tatttttgtc actgtcggaa cattgttcat cgtgatttaa aagctgaaaa      600

tttacttctg gatgccaatc tgaatatcaa aatagcagat tttggtttca gtaacctctt      660

cactcctggg cagctgctga agacctggtg tggcagccct ccctatgctg cacctgaact      720

ctttgaagga aaagaatatg atgggcccaa agtggacatc tggagccttg gagttgtcct      780

ctacgtgctt gtgtgcggtg ccctgccatt tgatggaagc acactgcaga atctgcgggc      840

ccgcgtgctg agtggaaagt tccgcatccc attttttatg tccacagaat gtgagcattt      900

gatccgccat atgttggtgt tagatcccaa taagcgcctc tccatggagc agatctgcaa      960

gcacaagtgg atgaagctag gggacgccga tcccaacttt gacaggttaa tagctgaatg     1020

ccaacaacta aaggaagaaa gacaggtgga ccccctgaat gaggatgtcc tcttggccat     1080

ggaggacatg ggactggaca aagaacagac actgcaggcg gagcaggcag gtactgctat     1140

gaacatcagc gttccccagg tgcagctgat caacccagag aaccaaattg tggagccgga     1200

tgggacactg aatttggaca gtgatgaggg tgaagagcct tcccctgaag cattggtgcg     1260

ctatttgtca atgaggaggc acacagtggg tgtggctgac ccacgcacgg aagttatgga     1320

agatctgcag aagctcctac ctggctttcc tggagtcaac ccccaggctc cattcctgca     1380

ggtggcccct aatgtgaact tcatgcacaa cctgttgcct atgcaaaact tgcaaccaac     1440

cgggcaactt gagtacaagg agcagtctct cctacagccg cccacgctac agctgttgaa     1500

tggaatgggc ccccttggcc ggagggcatc agatggagga gccaacatcc aactgcatgc     1560

ccagcagctg ctgaagcgcc cacggggacc ctctccgctt gtcaccatga caccagcagt     1620

gccagcagtt acccctgtgg acgaggagag ctcagacggg gagccagacc aggaagctgt     1680

gcagaggtac ttggcaaata ggtccaaaag acatacactg gccatgacca accctacagc     1740

tgagatccca ccggacctac aacggcagct aggacagcag cctttccgtt cccgggtctg     1800

gcctcctcac ctggtacctg atcagcatcg ctctacctac aaggactcca acactctgca     1860

cctccctacg gagcgtttct cccctgtgcg ccggttctca gatggggctg cgagcatcca     1920

ggccttcaaa gctcacctgg aaaaaatggg caacaacagc agcatcaaac agctgcagca     1980

ggagtgtgag cagctgcaga agatgtacgg ggggcagatt gatgaaagaa ccctggagaa     2040

gacccagcag cagcatatgt tataccagca ggagcagcac catcaaattc tccagcaaca     2100

aattcaagac tctatctgtc ctcctcagcc atctccacct cttcaggctg catgtgaaaa     2160

tcagccagcc ctccttaccc atcagctcca gaggttaagg attcagcctt caagcccacc     2220

ccccaaccac cccaacaacc atctcttcag gcagcccagt aatagtcctc cccccatgag     2280

cagtgccatg atccagcctc acggggctgc atcttcttcc cagtttcaag gcttaccttc     2340

ccgcagtgca atctttcagc agcaacctga gaactgttcc tctcctccca acgtggcact     2400

aacctgcttg ggtatgcagc agcctgctca gtcacagcag gtcaccatcc aagtccaaga     2460

gcctgttgac atgctcagca acatgccagg cacagctgca ggctccagtg ggcgcggcat     2520

ctccatcagc cccagtgctg gtcagatgca gatgcagcac cgtaccaacc tgatggccac     2580

cctcagctat gggcaccgtc ccttgtccaa gcagctgagt gctgacagtg cagaggctca     2640

cagtgcacat cagcagccgc cacactatac cacgtcggca ctacagcagg ccctgctgtc     2700

tcccacgccg ccagactata caagacacca gcaggtaccc cacatccttc aaggactgct     2760

ttctccccgg cattcgctca ccggccactc ggacatccgg ctgcccccaa cagagtttgc     2820

acagctcatt aaaaggcagc agcaacaacg gcagcagcag cagcaacagc agcaacagca     2880

agaataccag gaactgttca ggcacatgaa ccaaggggat gcggggagtc tggctcccag     2940

ccttggggga cagagcatga cagagcgcca ggctttatct tatcaaaatg ctgactctta     3000

tcaccatcac accagccccc agcatctgct acaaatcagg gcacaagaat gtgtctcaca     3060

ggcttcctca cccaccccgc cccacgggta tgctcaccag ccggcactga tgcattcaga     3120

gagcatggag gaggactgct cgtgtgaggg ggccaaggat ggcttccaag acagtaagag     3180

ttcaagtaca ttgaccaaag gttgccatga cagccctctg ctcttgagta ccggtggacc     3240

tggggaccct gaatctttgc taggaactgt gagtcatgcc caagaattgg ggatacatcc     3300

ctatggtcat cagccaactg ctgcattcag taaaaataag gtgcccagca gagagcctgt     3360

catagggaac tgcatggata gaagttctcc aggacaagca gtggagctgc cggatcacaa     3420

tgggctcggg tacccagcac gcccctccgt ccatgagcac cacaggcccc gggccctcca     3480

gagacaccac acgatccaga acagcgacga tgcttatgta cagctggata acttgccagg     3540

aatgagtctc gtggctggga aagcacttag ctctgcccgg atgtcggatg cagttctcag     3600

tcagtcttcg ctcatgggca gccagcagtt tcaggatggg gaaaatgagg aatgtggggc     3660

aagcctggga ggtcatgagc acccagacct gagtgatggc agccagcatt taaactcctc     3720

ttgctatcca tctacgtgta ttacagacat tctgctcagc tacaagcacc ccgaagtctc     3780

cttcagcatg gagcaggcag gcgtgtaaca agaaacagag agttttgtgt acagcttggg     3840

aatgaaaagg ttgattgt                                                   3858


<210> 3435
<211> 1623
<212> DNA
<213> Homo sapiens

<400> 3435
cgtgtgcaga cccgcgtgtg gcgcaggcaa ggaccctcaa aataaacagc ctctaccttg       60

cgagccgtct tccccaggcc tgcgtccgag tctccgccgc tgcgggcccg ctccgacgcg      120

gaagatctga ctgcagccat gagcagcaat gagtgcttca agtgtggacg atctggccac      180

tgggcccggg aatgtcctac tggtggaggc cgtggtcgtg gaatgagaag ccgtggcaga      240

ggtttccagt ttgtttcctc gtctcttcca gacatttgtt atcgctgtgg tgagtctggt      300

catcttgcca aggattgtga tcttcaggag gatgttgaag cctgctataa ctgcggtaga      360

ggtggccaca ttgccaagga ctgcaaggag cccaagagag agcgagagca atgctgctac      420

aactgtggca aaccaggcca tctggctcgt gactgcgacc atgcagatga gcagaaatgc      480

tattcttgtg gagaattcgg acacattcaa aaagactgca ccaaagtgaa gtgctatagg      540

tgtggtgaaa ctggtcatgt agccatcaac tgcagcaaga caagtgaagt caactgttac      600

cgctgtggcg agtcagggca ccttgcacgg gaatgcacaa ttgaggctac agcctaatta      660

ttttcctttg tcgcccctcc tttttctgat tgatggttgt attattttct ctgaatcctc      720

ttcactggcc aaaggttggc agatagaggc aactcccagg ccagtgagct ttacttgccg      780

tgtaaaagga ggaaaggggt ggaaaaaaac cgactttctg catttaacta caaaaaaagt      840

ttatgtttag tttggtagag gtgttatgta taatgctttg ttaaagaacc ccctttccgt      900

gccactggtg aatagggatt gatgaatggg aagagttgag tcagaccagt aagcccgtcc      960

tgggttcctt gaacatgttc ccatgtagga ggtaaaacca attctggaag tgtctatgaa     1020

cttccataaa taactttaat tttagtataa tgatggtctt ggattgtctg acctcagtag     1080

ctattaaata acatcaagta acatctgtat caggccctac atagaacata cagttgagtg     1140

ggagtaaaca aaaagataaa catgcgtgtt aatggctgtt cgagagaaat cggaataaaa     1200

gcctaaacag gaacaacttc atcacagtgt tgatgttgga cacatagatg gtgatggcaa     1260

aggtttagaa cacattattt tcaaagacta aatctaaaac ccagagtaaa catcaatgct     1320

cagagttagc ataatttgga gctattcagg aattgcagag aaatgcattt tcacagaaat     1380

caagatgtta tttttgtata ctatatcact tagacaactg tgtttcattt gctgtaatca     1440

gtttttaaaa gtcagatgga aagagcaact gaagtcctag aaaatagaaa tgtaatttta     1500

aactattcca ataaagctgg aggaggaagg ggagtttgac taaagttctt tttgtttgtt     1560

tcaaattttc attaatgtat atagtgcaaa ataccatatt aaagagggga atgtggagga     1620

ctg                                                                   1623


<210> 3436
<211> 826
<212> DNA
<213> Homo sapiens

<400> 3436
tttctctccg ctcccgtgag taacttggct ccgggggctc cgctcgcctg cccgcacgcc       60

gcccgccacc caggaccgcg ccgccggcct ccgccgctag caaacccttc cgacggccct      120

cgctgcgcaa gccgggacgc ctctcccccc tccgcccccg ccgcggaaag ttcgagaact      180

tgtcttggac aattgcaaat caaatgatgg aaaaattgag ggcttaacag ctgaatttgt      240

gaacttagag ttcctcagtt taataaatgt aggcttgatc tcagtttcaa atctccccaa      300

gctgcctaaa ttgaaaaagc ttgaactcag tgaaaataga atctttggag gtctggacat      360

gttagctgaa aaacttccaa atctcacaca tctaaactta agtggaaata aactgaaaga      420

tatcagcacc ttggaacctt tgaaaaagtt agaatgtctg aaaagcctgg acctctttaa      480

ctgtgaggtt accaacctga atgactaccg agagagtgtc ttcaagctcc tgccccagct      540

tacctacttg gatggctatg accgagagga ccaggaagca cctgactcag atgccgaggt      600

ggatggtgtg gatgaagagg aggaggacga agaaggagaa gatgaggaag acgaggacga      660

tgaggatggt gaagaagagg agtttgatga agaagatgat gaagatgaag atgtagaagg      720

ggatgaggac gacgatgaag tcagtgagga ggaagaagaa tttggacttg atgaagaaga      780

tgaagatgag gatgaggatg aagaggagga agaaggtggg aaaggt                     826


<210> 3437
<211> 606
<212> DNA
<213> Homo sapiens

<400> 3437
gactctcgcg agatccctac tggctataaa ggcagcgccc cggagagctc ttgcgcgtct       60

tgttcttgcc tggtgtcggt gctgatagga agatgtcttc aggaaatgct aaaattgggc      120

accctgcccc caacttcaaa gccacagctg ttatgccaga tggtcagttt aaagatatca      180

gcctgtctga ctacaaagga aaatatgttg tgttcttctt ttaccctctt gacttcacct      240

ttgtgtgccc cacggagatc attgctttca gtgatagggc agaagaattt aagaaactca      300

actgccaagt gattggtgct tctgtggatt ctcacttctg tcatctagca tgggtcaata      360

cacctaagaa acaaggagga ctgggaccca tgaacattcc tttggtatca gacccgaagc      420

gcaccattgc tcaggattat ggggtcttaa aggctgatga aggcatctcg ttcaggggcc      480

tttttatcat tgatgataag ggtattcttc ggcagatcac tgtaaatgac ctccctgttg      540

gccgctctgt ggatgagact ttgagactag ttcaggcctt ccagttcact gacaaacatg      600

gggaag                                                                 606


<210> 3438
<211> 429
<212> DNA
<213> Homo sapiens

<400> 3438
aaggggctct tgagggctcc tgcacccacc agaatgtgca gagaagaggt cccaggtggg       60

agccgagagg gggctgaggg cagatcccca agagagaagt aattggtgtg agagaggatc      120

tcaatttctt cgtgtctaaa atggggaaac tgcagcgcca cttaccctgc ctagggtgga      180

caagtccttc acttctcgcc ggagtgtgtg gaggagcgat gggcagaacc agcacttccc      240

tcaggcacta gacctgtcac gagtgaactt agttccctcc tatactcctt cactctaccc      300

taagaacaca gatctatttg agatgattga gaagatgcag ggaagcagga tggatgaaca      360

acgctgctcc ttcccgccgc ccctcaaaac agaggaggac tacattccat acccgagcgt      420

gcacgaggt                                                              429


<210> 3439
<211> 728
<212> DNA
<213> Homo sapiens

<400> 3439
aaagcgtggc agcgcaggcg caagcgcaga gagcggaggc ggtggtggtg gcggccgctg       60

gccagtgctg gctacagcaa acatcattca agatgtccag caaagggagc agcacagatg      120

gcagaacaga cttagctaat ggaagcctgt ctagcagtcc agaggagatg tctggagctg      180

aagaggggag ggagacatcc tcaggcattg aagtggaggc ctcagacctg agtttgagct      240

tgactgggga tgatggtggc cccaaccgca ccagcacaga aagtcgaggc acagacacag      300

agagctcagg tgaagataag gactctgaca gcatggagga cactggtcat tactccatta      360

atgatgaaaa tcgagtccat gaccgctcag aggaagagga agaggaggaa gaagaggagg      420

aagaagagca gcctcggcgc cgtgtacagc gcaagcgggc taaccgtgac caggactcat      480

cagatgatga gcgggcccta gaggactggg tgtcctcaga aacatcagct ctaccccgac      540

ctcgctggca agccctccct gcccttcggg agcgggagct gggttcaagt gcccgctttg      600

tctatgaggc ctgtggggca agagtctttg tgcagcgttt ccgcctgcag catgggcttg      660

agggccatac tggttgtgtc aataccctgc actttaacca gcgcggcacc tggctggcca      720

gtggcagc                                                               728


<210> 3440
<211> 1146
<212> DNA
<213> Homo sapiens

<400> 3440
gggagtttcg gaggcggtga ccgtgacgta gaaggtggag accgcttcac cctgatcagg       60

gagtatcggc tgcgggtgcg caaggcgtcc aggagtgacc tggggctgtg gagagcgacc      120

cgtggccttg tgtttcaggt acggaggttc cggactggac gggcgtcagg aagtcacaga      180

cttgtcctct gatgtggccc cgcccgccgc cgcactaatc tcttcggcgt cgtacccgtc      240

ggcccagctc gacccgccgc agccccggcc ccgaccgtgg acactggggg tccccgaggg      300

cgctgcgacc tcctcccggg tgaaatgaaa cccgagggca gtccccctta ccgaccccat      360

tagagacgta tctgccgtgc caggggtcta ggctccagaa acagggagtt taccacctag      420

gatgacttca gtgactagat cagagatcat agatgaaaaa ggaccagtga tgtctaagac      480

tcatgatcat caattggaat caagtctcag tcctgtggaa gtgtttgcta aaacatctgc      540

ctccctggag atgaatcaag gcgtttcaga ggaaagaatt caccttggct ctagccctaa      600

aaaaggggga aattgtgatc tcagccacca ggaaagactt cagtcgaagt cccttcattt      660

gtctcctcaa gaacaatctg ccagttatca agacaggagg caatcctggc ggcgagcaag      720

tatgaaagaa acgaaccggc ggaagtcgct gcatcccatt caccagggca tcacagagct      780

cagccggtct atcagtgtcg atttagcaga aagcaaacgg cttggctgtc tcctgctttc      840

cagtttccag ttctctattc agaaacttga acctttccta agggacacta agggcttcag      900

tcttgaaagt tttagagcca aagcatcttc tctttctgaa gaattgaaac attttgcaga      960

cggactggaa actgatggaa ctctacaaaa atgttttgaa gattcaaatg gaaaagcatc     1020

agatttttct ttggaagcat ctgtggctga gatgaaggaa tacataacaa agttttcttt     1080

agaacgtcag acttgggatc agctcttgct tcactaccag caggaggcta aagagatatt     1140

gtccag                                                                1146


<210> 3441
<211> 3007
<212> DNA
<213> Homo sapiens

<400> 3441
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg tggatggcca gggtacctgg     1200

ggactcaggc tgctgccagt tctgctcacc accatccgtg cttggcacag aagtagctgc     1260

atagaaaggg cactggattt gaagtcagaa gacctgggtt cttgaaccag cctgtcaacc     1320

agttgtatga ctttaaacaa ggcatctcac ctcttttcat cttgttttct tccaataatg     1380

ttagagttca tgtaatcaca ttctctagaa ccatttagtt tgtgttaact atgaaccaag     1440

cagtgtggtg gccactggtg acttgaaaat atagagaaaa aaaaaacctg ctctatatct     1500

gaaagagctc ttgggaagac agagaaacat aaagaggaaa ttacagcaca gtgtggtggg     1560

tgttacggga agtccaaccc cagcattatg ggagttcagg ggaaggggca tagcccagcc     1620

tggaaggaga gggtgagtgg gggatggctt tctgaaaagg gtggtctaaa ggatgcctat     1680

ggtcaatagg gaaaagaggg gaagaagcat cttaagaaga ggaaacagca gagaactggc     1740

tggatgacct gtgactctgg agcactgggt tgtctccatt gtcattatgg gcagatgtgt     1800

gccatcccca gccgacgcca ctcactgcct ccttcctcct ggtgttgcca cttctgggtg     1860

agattaaggt gcagggcctg ggggcaggag gacataaggt atagccataa atcataaccc     1920

agggaccaca ctcaacccta gggaaattgt cttcctgatc agttgattac catctgaggt     1980

caagaaatga gatagtggga gcaaatgggt cacaaatagc tcagctgtgg gctcagaaac     2040

tgctaggtaa aagaattcca gaaggaggcc agggcataag ttggatgacc tatgaacttt     2100

agtctaaaga attgagacta ccgtaattga gactactgta gtgacatctg agaaatggga     2160

tggaatagtg accatgtttt attttcttgt tcttgtcact attgtatttt attttgcata     2220

atcatgccct tcactgacag tctccttaac atcatctgtt tactctgctc agtgtaaact     2280

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2340

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2400

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     2460

gagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     2520

aaaatacaga cacacacaag tgcctatata atgataaaac atatccaaag cacccaaacc     2580

tgtgattcca gaaaagtaga tcctattttt gtttattttt attggcttta gctgtgtctt     2640

ttgaaaggac tattatcctc taaaatgtat gtgtatgaag atcctggctt gcagctcggg     2700

agctttacac accttgtgtc actttatctt ggtaacgagc caagatcatg caaccagttc     2760

atccatgtct gacccaagag ctcttaactg ctatgctgca ctgcctcatt cagagataga     2820

tgcctgcatg ggtcctggcg attattttaa tgctggctac acccccacag gtgacttgga     2880

ttcagaaata caatttatat ttcttctttt taaattgttt tattttattt ttcttttaat     2940

agttatatgt cagtgagaac aatttatatg tcttacactg agaaataaaa ctgctcataa     3000

gtgaaaa                                                               3007


<210> 3442
<211> 2947
<212> DNA
<213> Homo sapiens

<400> 3442
agactgagtg ctccggggag ctgtcagtgt caggctctgg gagagaggaa gtgatcgctc       60

ccggaggagc gcgagccgag cggccggcgc agcgtgagac agcacatcct gcccgcgccg      120

gccccgccac cttcgggagc cgcctgcacc aacgctgccg ccgcccagga gccgccgccg      180

gctcggggag cccagttccg ccgctgccga gcgcgtccag gaaaccaaca tgtctgacaa      240

aagtgactta aaagctgagc tagagcgcaa aaagcagcgc ttagcacaga taagagaaga      300

gaagaaacgg aaggaagagg agaggaaaaa gaaagaggct gatatgcagc agaagaaaga      360

acccgttcag gacgactctg atctggatcg caaacgacga gagacagagg ctttgctgca      420

aagcattggt atctcaccgg agccgcctct agtcccaacc cctatgtctc cctcctcgaa      480

atcagtgagc actcccagtg aagctggaag ccaagactca ggcgatctgg ggccattaac      540

aaggaccctg cagtgggaca cagacccctc agtgctccag ctgcagtcag actcagaact      600

tggaagaaga ctgcataaac tgggcgtgtc aaaggtcacc caagtggatt tcctgccaag      660

ggaagtagtg tcctactcaa aggagaccca gactcctctt gccacgcatc agtctgaaga      720

ggatgaggaa gatgaggaaa tggtggaatc taaagttggc caggactcag aactggaaaa      780

tcaggacaaa aaacaggaag tgaaggaagc ccctccaaga gagttgacag aggaagaaaa      840

acagcagatc cttcattcag aggaatttct catctttttt gaccggacaa tacgggtaat      900

tgaaagagcc ctggctgaag attccgacat cttttttgac tacagcggcc gagagttaga      960

ggaaaaagat ggggatgttc aggctggagc caatctttct ttcaatcgtc agttctatga     1020

tgaacattgg tccaagcatc gagtggtcac ttgtatggac tggtccctcc agtaccctga     1080

gctgatggtg gcttcttaca acaacaatga agatgctccc catgaaccag atggagtggc     1140

cttggtttgg aacatgaagt ttaagaaaac cacaccagaa tacgtcttcc actgtcagtc     1200

ctctgtgatg tcggtctgct tcgcccgttt ccatcctaac ttggtggttg gtgggactta     1260

ctcgggccag attgtcctct gggacaatcg cagtcatcga aggactccag tgcagcggac     1320

acccttatca gctgctgcac acacgcatcc cgtgtactgt gtaaatgttg ttgggaccca     1380

gaatgctcat aacctcatca ctgtctccac tgatggcaaa atgtgttcct ggagcctgga     1440

catgctctca actccacagg agagcatgga gctggtgtac aataagtcca agcctgtcgc     1500

tgttaccgga atggctttcc caacgggaga cgtcaataac ttcgtggttg gcagtgagga     1560

aggtacagtc tacacggctt gtcgtcatgg aagcaaagca ggtattggtg aggtctttga     1620

aggtcaccaa gggccagtga caggaattaa ctgccacatg gcagtgggcc caatcgactt     1680

ttctcacctg tttgtcacat catcatttga ctggactgtc aaactgtgga ccaccaagca     1740

caacaagccg ctctactcct ttgaagacaa tgcagactat gtgtacgatg tcatgtggtc     1800

ccccgtgcat cctgcgcttt ttgcctgcgt ggacgggatg gggcgcttgg acctctggaa     1860

cctcaacaat gacaccgagg ttccaacagc aagtgtggcc attgaggggg catccgccct     1920

aaaccgtgtt cgttgggccc aagctggcaa agaagttgct gttggggact cggaaggccg     1980

tatttgggtc tatgacgttg gagagcttgc agttccccac aatgatgaat ggacccgatt     2040

tgccaggacc cttgtggaaa ttcgtgctaa cagagctgat agcgaggagg aaggcactgt     2100

tgagttatct gcctagtgga aatgagccac ccccactgca gcccccacct ttgtgtccta     2160

gagctcagcg tctgcagtca agtctcttgt attcggtgtc cattcagtat cagtattgct     2220

gtgatatttt gggtgccata ttgtgccagc tttgctccaa gtattctaaa tgtgtcccat     2280

catgctttcc actgacccaa aattcaccac agcatttcta tctttatatt tctgtctcaa     2340

aaatgaagag aagggggtta tgggttaagt tgctgccttt taactacttt gtagctgtat     2400

ttaatagctg gaaacctctg gttaaatttg tgcttacatg cactcctggc atagtcctat     2460

taaatccata tgaagccaga tatgattggg tgcagatgtg gtgttcctca tattatggta     2520

cagggccaaa gacttgagac gtggtgtttt acatggtgac tcacattatg aatggattta     2580

ctagaagaac attgctgctc cttatttatt gtagtgtgct gcatggaacg tatttatttg     2640

aaagcattaa aataaatgat cctagagcat gtgcataatg agaggactgt attctctctg     2700

ctgctgttga ggttatatta agttccacat agcaattaca gtatgccagt tccactgaag     2760

acatgaaatc tttagaggtt tcttgcagtg aacgaaatga attttaatgc ctattatttc     2820

tgggtacttt aacaatattt caaatatcat tgaccactaa tacttctcac tgaagctaac     2880

acagtctgac aaaagtctat ggttcctaaa tatgacatca gtgttgccaa taaaatgttt     2940

caaacca                                                               2947


<210> 3443
<211> 4031
<212> DNA
<213> Homo sapiens

<400> 3443
acaccctcgc ggagagagcg gttcttgcag catcctgcgc agcccctgcc cagtttggtg       60

cagaggcgtg gggggcggga cgcgtctttg ccattctgat agcggggaaa gcggtgagaa      120

tcgaagtgag gagccgccag aggagagctg aggagaggag ggggaggtcg acgacctggg      180

ccctgggcct ctgaaggtct gtttctttct aggttcctgt agagatctgt atgtagctgt      240

tcacttggaa gttaattaag aaagaacaaa aactattcat ttggattcaa ggtccatctc      300

cactggtggc tgtggtggct ttggattgtt ggaagaccat caccttcagc aggtctgcac      360

ttgggaacaa tcattctccc ccagcccgag cgtgcctctg ccctctgtat cattgacaga      420

ggctgtatgt ttggaaagag aactttgtga ctgcagaact gacagttgac tctaattctt      480

gctaccaagt ttttccccga cccagtgaaa gagtgttaag acttcgacct aggacacatt      540

gagaaccaag gccaagactg gacagggcca tataactggg cttcaaccat ggctgggact      600

aagaataaga caagagccca ggccaaaact gaaaaaaagg ctgctataca agctaaagct      660

ggagcagaga gggaggctac tggtgttgtt aggcctgtag ccaagaccag ggccaaagca      720

aaagccaaga cagggtctaa gacagatgca gtagcagaga tgaaggcagt gtctaagaac      780

aaggttgttg ctgagacgaa ggaaggagct ctgtcagagc ctaagactct gggcaaagcc      840

atgggagatt tcactcccaa ggctgggaat gagtccacca gctccacatg taaaaatgag      900

gctggtactg atgcctggtt ctgggctggg gaagaggcca ctatcaattc ctggttctgg      960

aatggagaag aggctggtaa tagtttcagc actaagaatg ataaacctga aattggtgcc     1020

caggtctgtg ctgaggagtt ggaacctgcg gctggggccg attgcaaacc taggtcaggg     1080

gctgaggagg aggaggaaga gaatgttatt gggaactggt tttgggaagg agatgatact     1140

agttttgacc ctaatcctaa acctgtgagc aggatagtta agcctcagcc tgtgtatgaa     1200

attaatgaaa aaaataggcc caaggactgg tctgaggtaa ctatctggcc caatgcccct     1260

gctgtaactc cagctgtgtt aggatttaga tcccaggcac catctgaggc aagccctcct     1320

tcatatattg ttctggcctc cgctgaagaa aatgcctgtt ctttgcctgt ggcaacagct     1380

tgccgccctt ctaggaacac tcgctcatgc tcacagccta tccctgagtg tcgttttgat     1440

tctgacccct gcatccagac catagatgag attagacgtc aaatcaggat cagggaggta     1500

aatgggatta agccatttgc ttgtccttgc aaaatggaat gctatatgga ttctgaggaa     1560

tttgaaaaac ttgttagctt acttaagtca actactgatc ctcttattca taaaatagca     1620

cggattgcaa tgggtgtcca taatgttcac ccatttgccc aagagtttat taacgaagta     1680

ggtgtagtga cacttattga aagcttgctc agttttcctt cccctgaaat gagaaaaaag     1740

actgtaatta ctctgaatcc tccttctggg gatgaaagac aacgcaaaat tgaattacat     1800

gttaagcata tgtgtaaaga aaccatgtca tttcctttga actcaccggg acagcaatct     1860

ggattaaaga tactaggaca actgactact gattttgtcc atcactacat tgttgccaat     1920

tacttttcag agcttttcca tttgctgtcc tcaggaaatt gcaaaaccag aaatcttgtt     1980

ttgaaactac ttttaaatat gtctgaaaat ccaactgcag ccagagacat gatcaatatg     2040

aaggcattgg cagcattaaa actcatcttt aaccagaaag aggcaaaagc caatcttgtt     2100

agtggtgtgg ccatatttat taacataaag gagcatatca gaaaaggctc aattgtagtt     2160

gttgatcact tgagttataa tacactcatg gccattttca gggaagttaa agagattatt     2220

gaaacaatgt aaaatgagcc agagatagaa cattttaagc catcttcaaa ctctagcagg     2280

ctgtacatta cagtgtacac attatacact gcatctttaa cacagagtca cctgtgacag     2340

gctctaggtt tgagctagac tattttgggg gtatcaaatg aatattatac cttgggctga     2400

aaatgtttga tttttatctt gtctagattg gcatattttt aacattttac ttaagatagc     2460

aaaccagttc gttttaagta agctaacttg ttcattagta tctgtggctt aaaatggcaa     2520

aaaagaaaat atccttgagt ttgtaatcta gttacagaag taaggcatac acacacacaa     2580

agataacagt acctagagag agagtgtgtg tgagtgtgcg tgtctctgtg tgtgcacgtg     2640

cacgctcatg gccaaatgtg cgcactctac ataaaggagg caggagttcc tataggctat     2700

ttaatgtaag agaaactatt tttctcctgt tccagctgta tcagatactc gttccgcaac     2760

acagaaatga ctcagaatct cagacaaaat gtattatttg ttcaatttta attttgctac     2820

tacattcata actcttaaat tgttaggctg tttcatttac atcaaagtta tctcacaaaa     2880

gagaaggcag gaaacgtttt gtgagtgcct attctatgtc aaacactgtg ttggcaccat     2940

attttacaag tttttttcct cttctcacag tgatcttgtg agttagttac ttatattttt     3000

attagaactc attattctgg gtaccctcca atgagaatta gagaggttaa ataccttttc     3060

ctagattccc acagcaggaa ggtggcatag ctgttttgtc tgacaccaga acccatctca     3120

ccacactgct ttacagtctt cctgaaggac attttgaggt gggggggcct tcaaagctca     3180

gagactggtt tgaatggttt aattttgcaa tggatcatgt ccatgccagg tgttacaatt     3240

cttaacttcc tccaaattcg tgtgtccatt agacatttgg ctacatctgg ctggaggtca     3300

ggagaaaatt ctgaggtaaa tagatggatt ttatctggca gtgtcgaaaa tagtaggagc     3360

ctaaaacttt gttcaatgag taagatgtag atttggagtc atcagcaggg gaaacttgtt     3420

agatgtcctt tgtatctttt tctatccatt tgtatttttt ctttcccaaa gagctgaaat     3480

cattttatac cctgaattta aaaggtaatt gcttttttcc tccttgcgaa atcatacctt     3540

aatttttttt tttttttttt ttaccattta tgatttattc tcctatgtgt catatgaaag     3600

gccaaggggc tttatctttt actagtaggc aagcctgggc atttctgcat ttgtgccagc     3660

taacactaca aaatagactt aattagagaa atttagaccc agaattgcag cttcaacaac     3720

acaaaacagg aaagctagaa gaggttgctg tgtcaaccta caagatagtg attcttggaa     3780

gttggtatgg accagaaagc attcccagga catttaggct atggctgagt tctctaagac     3840

tcagggtggg aattataatc cctggtctaa gctgatatga aagtttctat gtgtgaaaat     3900

atggagttat atgctttgag attttctgcc agttaaacta aaacaagatc atactgtaaa     3960

tgtttgtaac ttgcttcccc ccactgtata ctgtaaacat ctttgcatgt caataaatat     4020

gcctctacaa c                                                          4031


<210> 3444
<211> 833
<212> DNA
<213> Homo sapiens

<400> 3444
attctcatcc ctgtgctcag agctctcaag cacccacgat ggccttctca ggccgagcgc       60

gcccctgcat tatcccagag aacgaagaaa tcccccgagc agcccttaac actgtccacg      120

aggccaatgg gaccgaggac gagagggctg tttccaaact gcagcgcagg cacagtgacg      180

tgaaagtcta caaggagttc tgtgactttt atgcgaaatt caacatggcc aacgccctgg      240

ccagcgccac ttgcgagcgc tgcaagggcg gctttgcgcc cgctgagacg atcgtgaaca      300

gtaatgggga gctgtaccat gagcagtgtt tcgtgtgcgc tcagtgcttc cagcagttcc      360

cagaaggact cttctatgag tttgaaggaa gaaagtactg tgaacatgac tttcagatgc      420

tctttgcccc ttgctgtcat cagtgtggtg aattcatcat tggccgagtt atcaaagcca      480

tgaataacag ctggcatccg gagtgcttcc gctgtgacct ctgccaggaa gttctggcag      540

atatcgggtt tgtcaagaat gctgggagac acctgtgtcg cccctgtcat aatcgtgaga      600

aagccagagg ccttgggaaa tacatctgcc agaaatgcca tgctatcatc gatgagcagc      660

ctctgatatt caagaacgac ccctaccatc cagaccattt caactgcgcc aactgcggac      720

aggaaggatc tgactgccga tgcacaggag ctgaaagggg agctatactg cctgccatgc      780

catgataaaa tgggggtccc catctgtggc gcttgccgac ggcccatcga agg             833


<210> 3445
<211> 660
<212> DNA
<213> Homo sapiens

<400> 3445
aggtgaggag gtgacccgcg ggaatgtgtg gggaaggaga atggaatcta attttaatca       60

agagggagta cctcgaccat cttatgtttt tagtgctgac ccaattgcaa ggccttcaga      120

aataaatttc gatggcatta agcttgatct gtctcatgaa ttttccttag ttgctccaaa      180

tactgaggca aacagtttcg aatctaaaga ttatctccag gtttgtcttc gaataagacc      240

atttacacag tcagaaaaag aacttgagtc tgagggctgt gtgcatattc tggattcaca      300

gactgttgtg ctgaaagagc ctcaatgcat ccttggtcgg ttaagtgaaa aaagctcagg      360

gcagatggca cagaaattca gtttttccaa ggtttttggc ccagcaacta cacagaagga      420

attctttcag ggttgcatta tgcaaccagt aaaagacctc ttgaaaggac agagtcgtct      480

gatttttact tacgggctaa ccaattcagg aaaaacatat acatttcaag ggacagaaga      540

aaatattggc attctgcctc gaactttgaa tgtattattt gatagtcttc aagaaagact      600

gtatacaaag atgaacctta aaccacatag atccagagaa tacttaaggt tatcatcaga      660


<210> 3446
<211> 1375
<212> DNA
<213> Homo sapiens

<400> 3446
gtacaacttc cggctgtaaa gatggcggct tcctagtgag tcggcggctg atttagaagg       60

aggttcaggc tacggtgagc cgaagccaca caggagccat ggaagtggca gagcccagca      120

gccccactga agaggaggag gaggaagagg agcactcggc agagcctcgg ccccgcactc      180

gctccaatcc tgaaggggct gaggaccggg cagtaggggc acaggccagc gtgggcagcc      240

gcagcgaggg tgagggtgag gccgccagtg ctgatgatgg gagcctcaac acttcaggag      300

ccggccctaa gtcctggcag gtgcccccgc cagcccctga ggtccaaatt cggacaccaa      360

gggtcaactg tccagagaaa gtgattatct gcctggacct gtcagaggaa atgtcactgc      420

caaagctgga gtcgttcaac ggctccaaaa ccaacgccct caatgtctcc cagaagatga      480

ttgagatgtt cgtgcggaca aaacacaaga tcgacaaaag ccacgagttt gcactggtgg      540

tggtgaacga tgacacggcc tggctgtctg gcctgacctc cgacccccgc gagctctgta      600

gctgcctcta tgatctggag acggcctcct gttccacctt caacatcagt ggggcctcac      660

ctgcccgcca gcagaaaact gagcttccgg tcacagagaa cgtgcagacg attcccccgc      720

catatgtggt ccgcaccatc cttgtctaca gccgtccacc ttgccagccc cagttctcct      780

tgacggagcc catgaagaaa atgttccagt gcccatattt cttctttgac gttgtttaca      840

tccacaatgg cactgaggag aaggaggagg agatgagttg gaaggatatg tttgccttca      900

tgggcagcct ggataccaag ggtaccagct acaagtatga ggtggcactg gctgggccag      960

ccctggagtt gcacaactgc atggcgaaac tgttggccca ccccctgcag cggccttgcc     1020

agagccatgc ttcctacagc ctgctggagg aggaggatga agccattgag gttgaggcca     1080

ctgtctgaac catccctgta catctgcacc ttcttgtgca aggaagtcct tggcctaaag     1140

ccttggttct caaactgggt tccttgggac ctccggggtg ggggggttcc aggaggcacg     1200

tagggtacct tgcagggtcc taggagggaa acccaggatt ccaggaggga tcccaggaac     1260

tgtgggcacc cattttctgt gtctcccagc ccatttccac tcctagtttg tcatggataa     1320

tttttgttct tccctgtgtg atttttgcca tcaaaataaa aatttgagac tcgtt          1375


<210> 3447
<211> 3478
<212> DNA
<213> Homo sapiens

<400> 3447
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cggttgcttc      180

attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt      240

gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc tgtcgattga      300

ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt actgtgcttg      360

ctcctgactc tatgtcgcgt cttcaaggag aagaagtcct caccagtgaa cggagacctc      420

tctgaactaa ggataccatg gccacgtcag ccccactacg gagcctggaa gaggaggtga      480

cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt ggccacgtct      540

tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc gtctgcccac      600

tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg gccagcctgg      660

tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag gtgacccggg      720

agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac tactgtgagg      780

acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg      840

ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac cacctgagta      900

ccctaaggag ggacagagac aaaattcagg gcttccaggc aaagggagaa gctgatatcc      960

tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag tttgagcagg     1020

gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg aagctggagc     1080

aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag cttgcccggc     1140

tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca gagctcatgc     1200

aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt gggaaaccca     1260

ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc tctctgcaac     1320

gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag acagtgagcg     1380

tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac tggaagtgcg     1440

tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt gactgtgagc     1500

ctggggtgct aggcagcaag ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg     1560

agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag ggagaagagg     1620

aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa acggacgaag     1680

atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag gaagttctgg     1740

aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac ctctccctgc     1800

ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg gccaacacca     1860

gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc gccctggatt     1920

atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc tacaccttca     1980

ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca ggaacacgcc     2040

tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag atgcttcact     2100

tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag cacctggagc     2160

aggggacccc atatccactg gtagccacct ccccattgct gtggccccct gaaatctcac     2220

tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc ctgctggttt     2280

cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg accacgacct     2340

tggccccagc tctgcactct ctggaataag ggcccgatgc agcattttct tgcccagtgt     2400

ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt ccttaaaccc     2460

cccaggttcc ttcttgcaca aatccactct gctgcccacc ttccctggca ttttaaacag     2520

acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat aaacaaaatc     2580

cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat ctcatggggt     2640

ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat agccaaggag     2700

gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac acggctttgg     2760

ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg tgaggggagt     2820

tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca agacaaacat     2880

ccagtggagc agaacctctc ctgcctcggg agttctgacc gggttcccca gcagggtgtt     2940

aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag agagtggaga     3000

tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa     3060

gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca ggtgcccctc     3120

atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc agtcttgtcc     3180

ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc ctccaccctg     3240

ttctaagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac cattgtctca     3300

gagctgccca ctttgtgtgt gtcacatgct gcctgagtca catgtacatc ttatttctgc     3360

ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt gtattctcat     3420

ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt tgaatgaa       3478


<210> 3448
<211> 6344
<212> DNA
<213> Homo sapiens

<400> 3448
atgtctgaga gccccaagga cgagggctcc gaagagtgtc tgtttctgca gcgcctatgg       60

gagtgggggg cagtgggggg aactcaggga agctgcctac aacttgaggc cttccccagg      120

ctggaggagg aggacaggga aggccgaggg gagctgtcct ccggctgcca tcaccctgat      180

gaggcggccc tgccccgggc tgtggtctcc gcaggggctg gcaaccttgc ctttgtccag      240

ctctctccgt ggccaggcct gccatctgcc tgcccacact cctccccggc aaagcccctt      300

gcaaatgctt gctttgggga ctggcagctt tcgcctctga atcaggacct agcatcagta      360

ctctggggag ggggtccagg tgccaaccct gtgagtccct ccctgtcccc tgacgctgag      420

aaggccctgc caacccccac catgtgtgag gtgatgccca caatcaatga gggggaccgc      480

ctgggtcccc ctcatggcgc cgatgctgac gccaacttcg agcagctgat ggtgaacatg      540

ctggacgagc gggagaagtt gctggagtct cttcgggaga gtcaggagac cttggcggcc      600

acacagagcc ggctccagga tgccatacac gagcgggacc agctccagcg ccaccttaac      660

tccgccctcc cccaggaatt tgccacctta acccgggagc tgagcatgtg tcgggagcag      720

cttctagagc gggaggaaga gatatcagaa ctgaaagcag aacggaataa cacacggctg      780

cttctggaac atctggagtg cctggtgtcc cgccatgaac ggtcactgcg gatgactgtg      840

gtgaagcgcc aggcccagtc accttcgggg gtctccagtg aggtggaggt gctgaaggcc      900

ctcaagtcac tgtttgagca ccacaaggcc ctggatgaga aggtgcgaga gcggctccgg      960

gcagcgctgg agcgagtcac caccttggag gagcagctgg caggtgccca ccagcaggtg     1020

tctgccctgc agcagggggc aggggtgcgg gatggagcgg cagaagagga ggggactgtg     1080

gagctggggc cgaaacgcct gtggaaggag gatacgggcc gggtagagga gctgcaggag     1140

ctcctggaga agcagaactt tgagttgagc caggcccggg agcgactggt caccctaaca     1200

acaaccgtga ctgaactcga ggaggacctg ggcacggccc gccgggacct catcaagtcg     1260

gaggagctga gcagcaagca tcagcgggac ctccgggagg ctctggccca gaaggaggac     1320

atggaagagc ggattactac actggagaag cgctacctgg ctgctcagcg tgaggcaaca     1380

tccatccatg acctcaatga caagctggag aatgagctgg ccaacaagga gtccctgcac     1440

cgccagtgtg aggagaaggc ccgacacctg caggagctgc tggaggtggc agagcagaag     1500

ctgcagcaga cgatgcgcaa ggcagagacg ctgccagagg tggaggctga gctggcccag     1560

agaattgcag ccctcaccaa ggctgaagaa cggcatggca acattgagga gcacctgcgg     1620

cagctggagg gacagctgga ggagaagaac caggagctgg cacggacggc tgtgcaggtg     1680

cgccagcggg aaaagatgaa tgaggaccac aacaagcggc tgtcggacac agtggaccgg     1740

ctgctcagcg agtccaacga gcgtctgcag ctccacctga aggagcgcat ggctgccctg     1800

gaggagaaga acacgttgat ccaggagttg gagagctccc agcggcagat tgaggagcag     1860

caccaccaca agggccgcct gtctgaagag attgagaagc tgcgccaaga ggtggaccag     1920

ctgaagggcc gaggggggcc gtttgtggat ggcgtccact ccaggtcgca catgggcagt     1980

gcagcagacg tgcggttctc cctgggcaca accacacacg cacccccagg cgtgcatcgc     2040

cgctactcgg cattgaggga agagtctgcc aagctggccc tgcctttgac agtgaccctg     2100

agatctccga cgtggatgag gatgagccag ggggtctgct gcaacttaga gtaccacagt     2160

tcagggaccc tctgtgggtc atcaggcccg ctgccagtgc cggagatgat tcaggaagag     2220

aaggagtcca cggagctccg cgcggaggag attgagacgc gtgtaaccag tggcagcatg     2280

gaagccctaa acctgaagca gctgcgcaag cgtggttcca tccccacctc tctgacggcc     2340

ctgtccctgg ccagcgcgtc cccaccactc agcggccgct ccacacctaa gctcacctcc     2400

cgcagtgctg cccaggacct ggaccgaatg ggggtcatga ccctgcccag tgacttaaga     2460

aagcatagga ggaagctgct gtcgccagtg tctcgggaag agaaccgaga ggataaagcc     2520

accataaaat gtgagacttc tcctccttcc tcacccagga cgctgcggct agagaagctt     2580

ggccacccag ccctgagcca ggaagaaggc aagagtgcct tggaggatca gggcagcaac     2640

cccagcagca gcaacagcag ccaggactcc ctgcacaagg gcgccaagcg caagggcatc     2700

aagtcgtcca ttggccgcct gtttgggaag aaggagaagg gcaggctgat ccagctgagt     2760

cgggatggag ccacaggcca tgttctgcta acagactccg aattcagtat gcaggagcct     2820

atggtgcctg ccaagctggg gacccaggca gagaaggacc ggcggctaaa gaagaaacac     2880

cagctgcttg aagatgcccg caggaaagga atgccctttg cccagtggga tggtcctact     2940

gtggtctcct ggttggagct ctgggtgggg atgcctgcct ggtatgtggc agcctgccgg     3000

gccaacgtca agagtggtgc catcatgtcc gctctgtcgg acacagagat ccagcgggag     3060

atcggcatca gcaatgccct gcaccggctc aagctccgcc tggccattca ggagatggtg     3120

tcattgacca gcccctctgc cccacccacc tccaggactt cttctgggaa tgtctgggtc     3180

acccatgaag agatggaaac tctggaaaca tctactaaaa cagacagtga ggagggcagc     3240

tgggctcaga ccctggccta tggggacatg aaccatgagt ggattgggaa tgaatggcta     3300

cccagcctgg ggctcccgca gtaccgcagc tacttcatgg agtgcctggt ggacgcccgc     3360

atgctggacc acctcaccaa gaaggacctg cgggtccacc tgaagatggt ggacagcttc     3420

catcgaacca gtcttcagta tggcatcatg tgtctgaaga ggctgaatta tgaccggaag     3480

gagctggaga agaggcgaga ggagagccag catgagatca aggatgtgtt agtctggacc     3540

aacgaccagg tggttcattg ggtccagtct attgggctcc gggactacgc aggaaacctg     3600

catgagagtg gtgtgcatgg agccttgctg gccctggacg agaacttcga ccacaacaca     3660

ctggccctga tcctccagat ccccacacag aacacccagg cacgccaagt gatggaaaga     3720

gagttcaata acctgttggc cttgggcaca gaccggaagc tggatgacgg ggatgacaag     3780

gtgtttcgcc gcgcgccctc ctggaggaag cgcttccggc cgcgggagca ccacggtcgc     3840

ggcggcatgc tcagcgcttc cgcggagacc ctcccggcgg gcttccgtgt gtccaccctg     3900

gggaccctgc agcccccacc ggccccgcca aagaagatca tgcctgaagc tcactcccac     3960

tatctctacg gacacatgct ctccgccttc cgggactagc catggccccc agggctggct     4020

tcctccttct gggtttcaca ggctcctctg gccctgaccc ctcttgctcg ttccccttcc     4080

ttccgcagct cctagtctcg tccgtgactt tccggttgcc ctggatctca gaatatattc     4140

gtccaccccc tcggcacccc attaccccga gtcccaccgt gtgtccgttg taagtccggt     4200

ggatgtggct ggggtttcct ggtattgtgg aggcacccag gttgtccatg cttgggattc     4260

tgggggaagg agagaagggc agctcagggt ggatgtgaag ccacccttcc tcttctggac     4320

ccagcctggt ctgcactgca acctccacca ggaccaggat cctgggccac aggctgggat     4380

ggtccttcca agaaagggtc atttcagacg cagccctgct tgggctattc aatcttaggg     4440

tgtctatcca cgtctggctg tgccaaatgg tctggcagct ggttttggca tccccagcat     4500

caccactctc ccaacccatc accgtgactg cagttcctgc ccccattctc ttggggtcag     4560

ggaggggctg ggaagggcta ctgaaggccc cattctccca caggatggtg aggctgggag     4620

gaggaagact gaggtagaga ttccaggccc tggcataagc tgaatcccaa atttgagttt     4680

gggaagaacc agagagaaat ggatccctga gctctgagcc aagggtgagg atggggaaac     4740

tctaagctcc cacctaataa gaagcatagg cagaccagcc agagggagag ccaatggcct     4800

ctggtagcct taagcccaaa gggcagtggg aatgtcccct gccccaacca tcgggtggag     4860

ctcctgctgg gctatgggga agggaggttg tgcggatctt gactctaggg cagaacagat     4920

ctaaccatgc attgctagct ctgctcccag catcccttcc ccttctctcc tcctctgcct     4980

cacttcttta gtaatcccaa ccctataaaa atgaacctaa tgggtggatt gaatatacat     5040

tgagcccaaa gtcaagtttg gggaaaaggc agactaaggc ctcctttctc tgacctccca     5100

ggaagaaaat agcttctcct acagtgattc atgtcccagg tccaggaaat ccaatgttgg     5160

tgaaggcagc cactctcttg cttgtcccca aatcacctaa ccctcatcca gggctatttt     5220

ggtgggcagg gactgcctcc tcccggaatt cctaagatcc gcccagctgc caccattttc     5280

attgctttcc ccagcagcat gatgggaacc caagctgagg gatacaggtc ctgatttggt     5340

aggaatatta ttcccaagaa atacccgctc ctcacctact ccctcatcct accaaggtgc     5400

ctgaaaatgt tcaagactta tgttcagggt gggatgatgg aaccgagggc ttcatcaaag     5460

tgagaggaaa ggaaaagcat ctggcatgtg tttcttggat aggggccagt gcagtgccat     5520

cctacaggtg gctggagcag ctgctttgca acctgatcac cttgagttct gagcagggac     5580

taggcttgca ggtgagataa tgggccaggg cacccagtcc agaaggagca atggcacctg     5640

ggcagtgcca gggcttaaag cccgctgctc cttttcggta gaggagaggc ccatcactgg     5700

tgtggtgggg tgggctctcc cttaggcttg ggcaaggcag ccacctgccc ttgctctccc     5760

ttagtgttcc ctggcctccc tgccatcagg ttgctgggag tggagatgga gggattattg     5820

agcagaaaat gagttggatg gagataaaca gctcccatcc ctgggtaatg gatggtaaga     5880

tgatggagat tcctaagatt ggtggagttg ggcaatgcat agccatctga ctccttcagg     5940

gtgctcttga tgggctggct gtaagggaga ctcagtccca gcctctcccc tctacaactc     6000

ctgccactgt tggccatgtc gtaaggcagc agctgtgcca ggatagctgg gtccattcag     6060

agcaccttga gaagtgttgc agggaggtgt taagaagaga actctgtgca aacagtgatg     6120

gaaggctgtt gtcttggtgt atcccttgcc tcatagtcaa tatatttttt ttttggcgag     6180

tcaccagtga cccgagccct ccacaccagc ctcctgtatc tcatcaggtc ccttctcagt     6240

actgtatttg ctcagtgcat caggaatggg tgtatgggtg tgtgtgggtg ggtgtgagtg     6300

tgggtgtgta cgtaccaata aacaacctgg ttttaagaca atgt                      6344


<210> 3449
<211> 2317
<212> DNA
<213> Homo sapiens

<400> 3449
gctttttgcc atcctgggcg ctagagggaa ttgcgctgca attcattaaa ttgcctctca       60

gtctcaacag atgacaaacc ccttgccctt gcctctgatt taagagaaag ccacagatgg      120

ctccctgcag agcgaggact gggccctcaa catggagatc tgcgacatca tcaacgagac      180

ggaggaaggt cccaaagatg ccctccgagc agtaaagaag agaatcgtgg ggaataagaa      240

cttccacgag gtgatgctgg ctctcacagt cttagaaacc tgtgtcaaga actgcgggca      300

ccgcttccac gtgctggtgg ccagccagga cttcgtggag agtgtgctgg tgaggaccat      360

cctgcccaag aacaacccac ccaccatcgt gcatgacaaa gtgctcaacc tcatccagtc      420

ctgggctgac gcgttccgca gctcgcccga tctgacaggt gtggtcacca tctatgagga      480

cctgcggagg aaaggcctgg agttccccat gactgacctg gacatgctgt cacccatcca      540

cacaccccag aggaccgtgt tcaactcaga gacacaatca ggacaggatt ctgtgggcac      600

tgactccagc cagcaagagg actctggcca gcatgctgcc cctctgcccg ccccgcccat      660

actctccggt gacacgccca tagcaccaac cccggaacag attgggaagc tgcgcagtga      720

gctggagatg gtgagtggga acgtgagggt gatgtcggag atgctgacgg agctggtgcc      780

cacccaggcc gagcccgcag acctggagct gctgcaggag ctcaaccgca cgtgccgagc      840

catgcagcag cgggtcctgg agctcatccc tcagatcgcc aatgagcagc tgacagagga      900

gctgctcatc gtcaatgaca atctcaacaa tgtgttcctg cgccatgaac ggtttgaacg      960

gttccgaaca ggccagacca ccaaggcccc aagtgaggcc gagccggcag ctgacctgat     1020

cgacatgggc cctgacccag cagccaccgg caacctctca tcccagctgg caggaatgaa     1080

cctgggctcc agcagtgtga gagctggcct gcagtctctg gaggcctctg gtcgactgga     1140

agatgagttt gacatgtttg cgctgacacg gggcagctca ctggctgacc aacggaaaga     1200

ggtaaaatac gaagcccccc aagcaacaga cggcctggct ggagccctgg acgcccggca     1260

gcagagcact ggcgcgatcc cagtcaccca ggcctgcctc atggaggaca tcgagcagtg     1320

gctgtccact gacgtgggta atgatgcgga agagcctaag ggggtcacca gcgaaggtaa     1380

atttgacaaa ttcctggaag aacgggccaa agccgcggac cgattgccca acctctccag     1440

cccctcagct gaggggcccc cgggtccccc atctggccca gcgccccgga agaagaccca     1500

ggagaaagat gatgacatgc tgtttgcctt atgagtgtgg ggtctggcac cctgcagccc     1560

aggtccccac tgctctcaca cccttaggct gggacctccc tccctcctct ggtgttaagg     1620

ctgctttggg ggtggcttgt tacccccttt tcctcctctt tgaagacgga gctgccccag     1680

ctgtggctgg gggtgtggag gcagtgggat gaactggggg acaggtctgc gctgcagtgg     1740

gatctggctg ctctgcctcc tttcccaccc cagctgacca tgagactttg ctgagaagtg     1800

gaggccccag gacaggctgg ctggctggct ggctgcttga cccagtgtga ctctccttca     1860

ctgagtgata ccctgctccg ggcccatgcc ccaaggagcc cttcagagcc cacactgcca     1920

gtcgaggcct ggctggaggc tggccacagt ggaaattctg ccgagcctct tgtcccttcc     1980

ctgctctgct gcatggggcc ccatggcttt ggctggccac tgagggtagg gtgtggaggt     2040

gtggaggccc cctgaggagc tgcggcggcc caggtacgaa gctgcaactc tgcgcgcagt     2100

gggcgagatc tcatcagccc caggctgcag gtgaggcttc aggggatgct ggggccccac     2160

tgcccctccg ctgccttgcc ctccatcctt cctctgttcc ttctggccgg gcaccacagc     2220

actggggctc acctcttggt tgatcctctt gtactgggag aggtgccttt tgtatcccca     2280

attaaaggta gaaaaccacc ctgctagcag cattgtc                              2317


<210> 3450
<211> 1241
<212> DNA
<213> Homo sapiens

<400> 3450
gggtctggta gattatcctg atgatgatga agatgatgat gaggatgaag ataaggaaga       60

tacgttacca ttgtcaaaga aagcaaaatt tgattcataa taatggcaac ggcctaggat      120

cagtacctgt tgaaaaactg gttctccacc cctcccccat acaaaatcca caacaaagcg      180

cagtggtctc ttgtgaatga ctgacacaga tcagcctctt acacttgact tctgctcatc      240

aagtgccaat tcaatggagc aggaggaggg gatatcatat atttagggga aagacttaag      300

cctttgagct ctccagcttg gaccacacat tgcccttttc tcagggaagg aaatggaaac      360

aaaaagccaa cagggcaggg gttttgtaag tggaactctg gattgactgg tcagttgcta      420

caatcagaat atgctttctt ggaccatgtt tgagactcag aagaatgggc ctttctgcca      480

taattcttca ctagtcaaga atgccagcag tttctttgta taaagagacc tgcctttaaa      540

atcatacatt ctgaacattt tagtcaagct acaacaggtt tggaaaacct ctgtggggga      600

ggggcgagta taaagttttc ctctttttta actgttccct ttgcccttca aactgcagat      660

attttttttt ttaagtgggg acttctccct acttgattaa agattgagtg gaattctaga      720

tgtggtcatt tgtgtcataa tttttttgtt ttattttgtt tttgattttt tttttcctcc      780

cctgagtgta tgcttagttg ttgagtatat atatttggga ccattaaaac tttttttgat      840

gtaatataac ctaacgttgt gctggtacct gttttaccat gtgtaatttt tgttctacat      900

cacagttctt aatttgttta gagttttatg aaagatggta tagtttttat tgacaaaagc      960

aaagtaatct tacaactatg tgcatacaaa agcaatacta ttttgtgact aaatatttta     1020

tattaaaatt tacatcagca actgtcttga gaattcaggg aaatagaatg gaatttaaaa     1080

cttcaacagt tttgttaaat ctagaaacat gaaattagta ttccaaagag attctgaaat     1140

ttcttttctt ggggaaatga cggtacatta aatcaaaatt gaggatggat gatttaaaaa     1200

catttgactt ttgaataata aaaagaaaag tgaagagtaa g                         1241


<210> 3451
<211> 765
<212> DNA
<213> Homo sapiens

<400> 3451
cggcgggggc gacccgggtg ccggcccgtg cgggcgacac gcgcgtctct gcggggctgc       60

gcggggtccg gagcggctgg gggctctctg ccgggcgcgg ctgggcgcgg ggggcgctcc      120

cggccgggat gagctcaccg cagtcgcgcc ggggctgagc gccgagcggg gcggcggcgg      180

ggcgggcggc ggctcctcgg cggctccgcg gcgcccgggc cgcgcgccgc catgctgggc      240

ctggacgcgt gcgagctggg ggcgcagctg ctggagctgc tccggctggc gctgtgcgcc      300

cgagtcctcc tggctgacaa ggagggtggg ccgccggcag tggacgaggt gttggatgag      360

gctgtgcccg agtaccgggc gccggggagg aagagcctct tggagatccg gcagctggac      420

ccggacgaca ggagcctggc caagtacaag cgggtgctgc tggggcccct gccaccggcc      480

gtggacccaa gcctgcccaa tgtgcaggtg accaggctga cactcctgtc ggaacaggct      540

ccggggcccg tcgtcatgga tctcacaggg gacctggctg ttctgaagga ccaggtgttt      600

gtcctgaagg aaggtgttga ttacagagtc cacagggaga ttgtcagcgg cctcaagtgt      660

ctgcaccaca cctaccgccg gggcctgcgc gtggacaaga ccgtctacat ggtgggcagc      720

tatggcccga gcgcccagga gtatgagttt gtgactccgg tggag                      765


<210> 3452
<211> 1604
<212> DNA
<213> Homo sapiens

<400> 3452
acatgggagg aaaattcagt ttcagctcag ctagggattt agtcttacta aagacgcggg       60

aggaagttct ccagcgagca gctttcccca acgtggaaag gaccacgcaa ggacacctga      120

gctttccaac agatgttcag cgccagggga tccacagttc tgggaggtga tctctgatga      180

acatgccatc gactccgctg gcacctacca cggggacagc cacctgcagc tggagcgcat      240

caacgtgtac tacaacgagg ccagcggtgg caggtacgtg ccccgcgctg tgctcgtgga      300

tctggagccg ggcaccatgg actctgtgcg ctcggggccc ttcgggcagg tcttcaggcc      360

agacaacttc atcttcggtc agtgtggggc cggaaacaac tgggccaagg gacactacac      420

cgaaggcgcg gagctgatgg agtcagtgat ggacgttgtc agaaaggagg ctgagagctg      480

tgactgcctg cagggtttcc agctgaccca ctccctgggt ggggggactg ggtctgggat      540

gggtaccctt ctgctcagta agatccggga ggagtaccca gacaggatca taaacacatt      600

cagcatcctg ccctcgccca aggtgtcgga caccgtggtg gagccctaca acgccaccct      660

ctcagtccac cagctcatag aaaacgcaga tgagaccttt tgcatagata acgaagctct      720

gtatgacata tgttccaaga ccctaaaact gcccacaccc acctatggtg acctgaacca      780

cctggtgtct gctaccatga gtggggtcac cacgtgcctg cgcttcccgg gccagctgaa      840

tgctgacctg cggaagctgg ccgtgaacat ggtcccgttt ccccggctgc atttcttcat      900

gcccggcttt gccccactga ccagccgggg cagccagcag taccgggcct tgactgtggc      960

tgagcttacc cagcagatgt ttgatgctaa gaacatgatg gctgcctgtg acccccgtca     1020

cggccgctac ctaacggcgg ctgccatttt caggggtcgc atgcccatga gggaggtgga     1080

tgaacaaatg ttcaacattc aagataagaa cagcagttac tttgctgact ggctccccaa     1140

caacgtaaaa acagccgtct gtgacatccc accccggggg ctaaaaatgt cagccacctt     1200

cattgggaat aatacggcca tccaggaact cttcaagcgt gtctcagagc agtttacagc     1260

aatgttcagg cgcaaggcct tcctccactg gtacacgggc gagggcatgg atgagatgga     1320

attcaccgag gccgagagca acatgaacga cctggtgtct gaatatcagc aatatcagga     1380

tgccacggcc gaggaggagg aggatgagga gtatgccgag gaggaggtgg cctagaactc     1440

tccttttcta ggtaaagggg ggaagcagtg tggattcttt actgtgttct gacagccatg     1500

tgtcactata cgcttgttaa tttgtgtctt cacatctcct gctgcgtttt aaagcatttt     1560

tatagtatgc ggttttgact aataaagtat tctcacagca tctg                      1604


<210> 3453
<211> 1299
<212> DNA
<213> Homo sapiens

<400> 3453
gttcgggtcg tggggcggag ggaagagcgg gcgggcggga ggcgccggcg ccagacgcgg       60

agggaaggag ctacgagtag ccgccgagag gccgcggagc cagcgacgac cgacccagcc      120

gagccgccgc cgccgccgcg cccccatggc ggccgccaag gacactcatg aggaccatga      180

tacttccact gagaatacag acgagtccaa ccatgaccct cagtttgagc caatagtttc      240

tcttcctgag caagaaatta aaacactgga agaagatgaa gaggaacttt ttaaaatgcg      300

ggcaaaactg ttccgatttg cctctgagaa cgatctccca gaatggaagg agcgaggcac      360

tggtgacgtc aagctcctga agcacaagac cctgaagatc tgtgccaacc actacatcac      420

gccgatgatg gagctgaagc ccaacgcagg tagcgaccgt gcctgggtct ggaacaccca      480

cgctgacttc gccgacgagt gccccaagcc agagctgctg gccatccgct tcctgaatgc      540

tgagagtgag ccaagggccc tggggacctg cctgacttgg ggctcacctg cgtggcagcg      600

tggcgggtta tgtgcaacaa atgctgttgc cttttgggga gagggggcag taactgggaa      660

gtgtgtcgtg tgggctgccc tgccctgctg tttgggggcc atgcccagac tgaagccatg      720

agcagcgcct tcccccttaa actcaaagct gtgccaagta gctggtgaac agcagtgccc      780

gctcagccgc cttgtggctg gcactttggt ttgctctcca agctccggtt cccattagtt      840

gttgcggagc ctgaggccca acccagggct tcctcccagt gctgatcctc gtgccaggct      900

tctggttcac tggggccagg ggcccctcat ggttgcctgg gtgccagcag gggctgggca      960

gagagatcca caggcccagg ctgatctctt ccctgctcag aggtctttcc agtccagatc     1020

gtccaagctg cgtccagtgg ctcctggagg agtcagtggg tactgtggcc tggcgcctgg     1080

tagctggccg tttggtgcca agtgaccttg tccttgctgt gggcgtggct gccccagcag     1140

cctttccaac acggttggga gccgagcctg tggcaaagag gcccatgccc cttggttgcc     1200

tgagggtccg tgctctaccg ctctgcccaa atgggtgcag tcagatgaag gagacagaag     1260

gccagggccg atgtcaggtg gaccagtcct ttcttaggt                            1299


<210> 3454
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3454
aacagaccgc cgtgagagag gaggggcgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cgaagtcctc      180

accagtgaac ggagacctct ctgaactaag gataccatgg ccacgtcagc cccactacgg      240

agcctggaag aggaggtgac ctgctccatc tgtcttgatt acctgcggga ccctgtgacc      300

attgactgtg gccacgtctt ctgccgcagc tgcaccacag acgtccgccc catctcaggg      360

agccgccccg tctgcccact ctgcaagaag ccttttaaga aggagaacat ccgacccgtg      420

tggcaactgg ccagcctggt ggagaacatt gagcggctga aggtggacaa gggcaggcag      480

ccgggagagg tgacccggga gcagcaggat gcaaagttgt gcgagcgaca ccgagagaag      540

ctgcactact actgtgagga cgacgggaag ctgctgtgcg tg                         582


<210> 3455
<211> 4208
<212> DNA
<213> Homo sapiens

<400> 3455
gtgggaaacc taacgtcaaa gtctacgtag gaagtcgtag ggaaggcagc gaggaagacg       60

ctggctctcg ggtcacgtga tgcgccggga gcgtcatcgc ctcctccctc cccaagatgg      120

cgtccttgct gcagtcggac cgggttctct atctagtcca gggagaaaag aaggttcggg      180

ccccgctctc gcaactctac ttctgccgct attgtagcga actgcggtcg ctggaatgtg      240

tgtctcacga ggtggactcc cattattgtc ccagttgttt agaaaatatg ccatcggctg      300

aagccaaact aaaaaagaat agatgtgcca attgttttga ctgtcctggc tgcatgcaca      360

ccctctctac tcgggccacg agcatctcca cacagcttcc agatgaccca gccaagacca      420

ccatgaagaa agcctattac ctggcatgtg gattttgtcg ctggacgtct agagatgtgg      480

gcatggcaga caaatctgta gctagtggcg gttggcagga acctgaaaat cctcacacac      540

aacggatgaa caaattgatt gaatattacc agcagcttgc tcagaaagag aaggttgagc      600

gagatcgcaa gaaactggca cgacgtagaa actatatgcc tctggctttt tcggacaaat      660

atggtcttgg aaccaggctt cagcgaccac gagctggtgc atccatcagt acccttgccg      720

gactttccct taaagaagga gaggatcaga aagagataaa gattgagcca gctcaggctg      780

tggatgaagt ggaacctcta cctgaagact attatacaag accagtaaat ttaacagagg      840

taacaaccct tcagcagcgt ctgttacagc ctgacttcca gccagtctgt gcttcacagc      900

tctatcctcg ccacaaacat cttctgatca aacggtccct gcgctgccgt aaatgtgaac      960

ataatttgag caagccagaa tttaacccaa cgtcaatcaa attcaaaatc cagctggtcg     1020

ctgtcaatta tattccagaa gtgagaatca tgtcaattcc caaccttcgc tacatgaagg     1080

agagccaggt cctcctgact cttacaaatc cagttgagaa cctcacccat gtgactctct     1140

tcgagtgtga ggagggggac cctgatgata tcaacagcac tgctaaggtg gtggtgcctc     1200

ccaaagagct cgttttagct ggcaaggatg cagcagcaga gtacgatgag ttggcagaac     1260

ctcaagactt tcaggacgat cctgacatta tagccttcag aaaggccaac aaagtgggta     1320

ttttcatcaa agttacacca cagcgtgagg agggtgaagt gaccgtgtgc ttcaagatga     1380

agcatgattt taaaaacctg gcagccccca ttcgccccat tgaagaaagt gaccagggaa     1440

cagaagtcat ctggctcacc cagcatgtgg aacttagctt gggcccactt cttccttaaa     1500

aggttccact ggagggcaga tcccaaagga cagtatcacc gtaaacctgc gttaaaatgt     1560

ggaagctgct gcttcattag gccttgttta taacgatgta cccatgcact acggaattct     1620

attgctaaga aagtgggagc ataggcaagg cattgggaac acagggtagc tgctgttgct     1680

cttgctctca cccctgttga caccagtaag tctgtgtctc cctcactgaa ccctgcacgt     1740

tgagtaacag cagcataatt ccatcctagg aaaggggatg ggtgttcctt ggaatggcat     1800

tgtatttacc acctgagaaa ctctgtactg tctcttgatc tgatctcact aaggatcaca     1860

atgtcacaga tgaaacttaa atgataaccc aaaggtagac ctgctgttaa tgatccagca     1920

ttggtcacaa tgtaccaact gctttctgca ttccgttaaa tatcatctaa cagtctaaaa     1980

catatccctt cattgccata atggctgcca ttttgccata gatttccata taactgaaaa     2040

actgaattgt cactttatct ttagtatcat gatgattgga aaaacctgtg aagttgttaa     2100

ggcactctca tttgccctct ttttctaagt gaatacagga cacgtattag ttgttcttaa     2160

tttttttccc agtaaaatat ggatctttta agaagaattt gagaagcaaa caattacatg     2220

tcatgtcaag ggggtagcag attccattcg ttttcaatat tgccacaata cccagggatt     2280

aatgctgcca caggggggca atctttattt gtcttacttc ctaccccttc cctgttctgc     2340

ctctttaact cagttaagtt gttctgtttg ggacctggaa aagaacccaa agaaaacctg     2400

agtggacagg ttcatttctg gaatgcagaa aacattttaa aggctagatt tttagaatat     2460

tctcaactag cattctttcc attgatttga aggggaaatt aactattata atctcttgaa     2520

tccaaaactg gatattaaga actttccccc ttactaagtt taagactttt gtcatgtggt     2580

gagtcaaata agaccatttt gattgtaaac cataaaatag ttcagcaagt agcccacagt     2640

tctggcctaa cagcagactt gctgttttca cttggtatcc tggagttggg ttgctaacct     2700

taatttctat gatgttttct aaaatgaaac ttgataaagt agaccaccag ctgcaccgtg     2760

ttttctgtaa aagtattgtt agtaagtggc caagagactt gaggaaaata cagatttttt     2820

gtttaccttg gtcttgtttt aagtcttaaa aaattaaaga taacattata atgtagaata     2880

cagatgggac atagtccttg taagcttccc ttgaaaatgt tttaaatatt taggaagctt     2940

ttaaaagaca ctaaattgta ctctaaaaga cactaaattg tactaattgt acaaaggtca     3000

agccaatttt atgaaacagt cctacagagt aatatatgtg atgcagtgta agaaggaaaa     3060

tactcatctc taacattatg gtaataacat ttagcctctt aggagttgga gcagggggat     3120

gggtaattac agatttgcag actatagaaa gagtttcatt tttttgtgac cccacagagt     3180

ctcaaatttt tatttcacta cctgctagag cctactgtga aatcactgct ccatatttgc     3240

cagtggagga aatgggcata gagtagagaa tagcttcata tgtttacacg tttgcataga     3300

ctacacacat gtcatgcgtt tatggcaggt agctggtatt tattccccaa agtaataatg     3360

ttgaagtatg ggtctcatca ttcccataca cagaaacaca aaacactttg atcataaact     3420

tttttcttca gaagccaaac taacttgcag aataatagag ccactggttt aatgtttcct     3480

caagataggt tttagtgtaa gctagtattc tgtgtgttcg tagaaatgat tcaatacctg     3540

cagctggtga attaggaatt gtatttgttg ccttttttat attagatgag gtgcaaaaat     3600

tttaatgcta gtcagtatgc accaccacag gaaagttaga tcccattagc acttgaaact     3660

acagctttgg aaacttaggc taagttaatt tggatttgtt acttgattca cctactgacc     3720

ttttcttttg tttgaagtgc ttatcagcat aatgagctaa gtgtcatgca tatttgtgaa     3780

gaaacaccct ttttggtccc ttttgggaca gagaggtact ccttgatctt tatgaatgac     3840

aggttactgt tttgccttat tgcttaactt aatgtagtga aataaagcag acaaagcttg     3900

agcgtgtctt ttgtttgctc tcatgtagat actaagtagc atggctcaga gccaaaagac     3960

aagcgtgaag ttaagagagt tggctaagag agttggtggg gcatgctccc ttccattcct     4020

taaatgaagt aatctaaaat ctcttagcag gttagttcac cataatatat aagtagatgt     4080

tgctttgagc ttcttatata catattcaca gaaccattat ataaatgttg ttagacctct     4140

accagttttt atcctgggtc attgcttcta aagatatcct ttacaatata cacagtggtc     4200

tgactcca                                                              4208


<210> 3456
<211> 6310
<212> DNA
<213> Homo sapiens

<400> 3456
gccacaggga cagccggtgg gctcggtggg gctgcagaag gtcggggctg cactgctctc       60

ggcccccaca cggttggttg gttggcgtgg taagtgccct gatccctggt cctgagaact      120

caggctggca cagggattcc cagggcatct accaccacgc agctggagca gggctgagcc      180

caggagcatg gagatggacg cccccaggcc ccccagtctt gctgtccctg gagcagcatc      240

gaggcccggg aggctgctgg atggggggca cggcaggcag caggttcagg ccctctcttc      300

acagctcctg gaggtgatcc ccgactccat gaggaagcaa gaggtgcgga cgggcaggga      360

ggccggccag ggccacggta cgggctcccc agccgagcag gtgaaagccc tcatggatct      420

gctggctggg aagggcagtc aaggctccca ggccccgcag gccctggata ggacaccgga      480

tgccccgctg gggccctgca gcaatgactc aaggatacag aggcaccgca aggccctgct      540

gagcaaggtg ggaggtggcc cggagctggg cggaccctgg cacaggctgg cctccctcct      600

gctggtggag ggcctgacgg acctgcagct gagggaacac gacttcacac aggtggaggc      660

cacccgcggg ggcgggcacc ccgccaggac cgtcgccctg gaccggctct tcctgcctct      720

ctcccgggtg tctgtcccac cccgggtctc catcactatc ggggtggccg gcatgggcaa      780

gaccaccctg gtgaggcact tcgtccgcct ctgggcccat gggcaggtcg gcaaggactt      840

ctcgctggtg ctgcctctga ccttccggga tctcaacacc cacgagaagc tgtgtgccga      900

ccgactcatc tgctcggtct tcccgcacgt cggggagccc agcctggcgg tggcagtccc      960

agccagggcc ctcctgatcc tggacggctt ggatgagtgc aggacgcctc tggacttctc     1020

caacaccgtg gcctgcacgg acccaaagaa ggagatcccg gtggaccacc tgatcaccaa     1080

catcatccgt ggcaacctct ttccggaagt ttccatctgg atcacctccc gtcccagtgc     1140

atctggccag atcccagggg gcctggtgga ccggatgacg gagatccggg gctttaacga     1200

ggaggagatc aaggtgtgtt tggagcagat gttccccgag gaccaggccc ttctgggctg     1260

gatgctgagc caagtgcagg ctgacagggc cctgtacctg atgtgcaccg tcccagcctt     1320

ctgcaggctc acggggatgg cgctaggcca cctgtggcgc agcaggacgg ggccccagga     1380

tgcagagctg tggcccccga ggaccctgtg cgagctctac tcatggtact ttaggatggc     1440

cctcagcggg gaggggcagg agaagggcaa ggcaagccct cgcatcgagc aggtggccca     1500

tggtggccgc aagatggtgg ggacattggg ccgtctggcc ttccatgggc tgctcaagaa     1560

gaaatacgtg ttttacgagc aagacatgaa ggcgtttggt gtagacctcg ctctgctgca     1620

gggcgccccg tgcagctgct tcctgcagag agaggagacg ttggcatcgt cagtggccta     1680

ctgcttcacc cacctgtccc tgcaggagtt tgtggcagcc gcgtattact atggcgcatc     1740

caggagggcc atcttcgacc tcttcactga gagcggcgta tcctggccca ggctgggctt     1800

cctcacgcat ttcaggagcg cagcccagcg ggccatgcag gcagaggacg ggaggctgga     1860

cgtgttcctg cgcttcctct ccggcctctt gtctccgagg gtcaatgccc tcctggccgg     1920

ctccctgctg gcccaaggcg agcaccaggc ctaccggacc caggtggctg agctcctgca     1980

gggctgcctg cgccccgatg ccgcagtctg tgcacgggcc atcaacgtgt tgcactgcct     2040

gcatgagctg cagcacaccg agctggcccg cagcgtggag gaggccatgg agagcggggc     2100

cctggccagg ctgactggtc ccgcgcaccg cgctgccctg gcctacctcc tgcaggtgtc     2160

cgacgcctgt gcccaggagg ccaacctgtc cctgagcctc agccagggcg tccttcagag     2220

cctgctgccc cagctgctct actgccggaa gctcaggctg gacaccaacc agttccagga     2280

ccccgtgatg gagctgctgg gcagcgtgct gagtgggaag gactgtcgca ttcagaagat     2340

cagcttggcg gagaaccaga tcagtaacaa aggggccaaa gctctggcca gatccctctt     2400

ggtcaacaga agtctgacct ctctggacct ccgcggtaac tccattggac cacaaggggc     2460

caaggcgctg gcagacgctt tgaagatcaa ccgcaccctg acctccctga gcctccaggg     2520

caacaccgtt agggatgatg gtgccaggtc catggctgag gccttggcct ccaaccggac     2580

cctctccatg ctgcacctgc agaagaacag catcgggccc atgggagccc agcggatggc     2640

agatttgaag cagaacagga gtctgaaaga gctcatgttc tccagtaata gtattggtga     2700

tggaggtgcc aaggccctgg ctgaggccct gaaggtgaac cagggcctgg agagcctgga     2760

cctgcagagc aattccatca gtgacgcagg agtggcagca ctgatggggg ccctctgcac     2820

caaccagacc ctcctcagcc tcagccttcg agaaaactcc atcagtcccg agggagccca     2880

ggccatcgct catgccctct gcgccaacag caccctgaag aacctggacc tgacagccaa     2940

cctcctccac gaccagggtg cccgggccat cgcagtggca gtgagagaaa accgcaccct     3000

cacctccctt cacctgcagt ggaacttcat ccaggccggc gctgcccagg ccctgggaca     3060

agcactacag ctcaacagga gcctcaccag cttagattta caggagaacg ccatcgggga     3120

tgacggagcg tgtgcggtgg cccgtgcact gaaggtcaac acagccctca ctgctctcta     3180

tctccaggtg gcctcaattg gtgcttcagg cgcccaggtg ctaggggaag ccttggctgt     3240

gaacagaacc ttggagattc tcgacttaag aggaaatgcc attggggtgg ctggagccaa     3300

agccctggca aatgctctga aggtaaactc aagtctccgg agactcaatc ttcaagagaa     3360

ttctctgggg atggacgggg cgatatgcat tgccacagca ctgtctggaa accacaggct     3420

ccagcatatc aatctccagg gaaaccacat tggggactcc ggggccagga tgatctcaga     3480

ggccatcaag acaaatgctc ccacgtgcac tgttgaaatg tgatcctggt ggacggatca     3540

ggagaatggg cagatgctca gctggaagct tttgaacaga aaggccgact tctggggggc     3600

ctgtctggga gctgggaacg ctgcttgctc agcacgagag ccgggctctg cagggaggaa     3660

ggagaggtgc tgccggagga ggtcgtgagc tcctcttctg ctgcaggagt ggtccaggca     3720

gggggtgacg ggtactctgt tatggcacag agaagggagg ggccaccccc aagggactag     3780

gggccaaagg cctgaaagct gagcagtaca ggaggctggt tccagcttta caccctgagg     3840

acttcatgtg tccccaacct ttaaaaatgt ttattactgc ccctttccac tcacctggtt     3900

aaaaatcatc ccatgctctg agatgagctg ccacctcaag cccgtgagga gcatccgttt     3960

ggtaggggta acagagggga cccttcttta tcttctcaag aagaagattt cagggtatca     4020

tccttacaga catgaaaaag ctatgggaaa attgtgaaga taaatgaaag ttttaattct     4080

aggattctgg aaacagagac agtaagagtt ctccaaggat tttgcctttt ttgtttgttt     4140

ttgagatgga gtctcgctct tgtcgcccag gctggagtgc agtggcacga tctcagctcc     4200

ctgcaacctc cgcctcccgg gttcatgtga ttctcctgcc tcagcctccc cagtagctgg     4260

gaatacaggc acccgccacc atgcccggct aatttttgta gttttagtag agacggggtt     4320

tcatcatgtt ggccaggctg gtctcgaact cctgacctca ggtgatccat cagcctgggc     4380

ctcccaaagt actgggatta caggcatgag ccaccacacc tggccccatt ttttatttat     4440

tacaaaatca aagacatggg tgatgcctgg cacatgttgt ctggagtctg gcacactggt     4500

tatcaatagc acattcagtg tattcagtga tgtcattctt tatttatttt tgagacagaa     4560

tctgtcaccc aggctggagt gcagtggcat gatctcagct cactgtaggc tctacctcat     4620

gggttccagt gattctcctg cctcggcctc ccaagtagtt gggtctacag gcacgcacca     4680

ccacacccag ctaatttttg tatttttagt agagatgggg tttcaccatg ttgatcaggc     4740

tggtctttaa ctcctgacct caagtgatcc acccacctca gcctcccaaa gtgctgggat     4800

tacaggtgtg agccactgca cctggcagtg atgtcattcc ttactaggct tccaaagcca     4860

ctgctgtggc cacagcttcc atggagacag gcaagctgag cctctatgtg gcaccaattc     4920

ctgcagctgt ttgtgttgga gggaaaaaaa tccaaatgga catcaacagc tttcatcaac     4980

taaataacca cagaaaatat ttatgaagac tataaagcaa tgattacttt tgaattggaa     5040

aggaatcact attatttgaa atgtttcttc aaaagtgagc atccggacag gaaccatcat     5100

ggatgctgag gccatggatg aaggcctact cgggaagatg atatccttgc agtctcaaaa     5160

cggcacccca caaaggtgat atcctaattt acaaagggaa aaaggtacct taatctgaaa     5220

tctggcaaat gcagcctcaa cagaagtgac agaattgaac atcgccaata atgggacaca     5280

cagacatcac atgcccccag tctgatgcac cacggagtcg tctctgatgt attcttgtca     5340

aaaaatgttt gcctgattct aatcatgaaa gaacaattag aaaaaatcca aattgacaga     5400

tattctgcag aataaatggc ctgacctcat caaaaacatc aatgtcatga aaaacacaaa     5460

acattgcaga tagcgtgaaa ttaaagatta cagagatata atttaatgca agatctctga     5520

ctggatccta gactgcagga aaaagtctgc tataaagaac atttggatca cttgtagtag     5580

ctgggaaata aaacaaaaca ttatttgtaa aaggggggaa atctgaacat gggtcttgca     5640

gtatttatga cagtttttgc ggggcagaga tttctagatt gacagctgtt ttagtacttt     5700

caaggtgatg ctctgtctgc tggtttgcat tgtttctgtc tgagttaaga gactggcaga     5760

acacagagtt gcagtagcca aacactggag aaagctgggc cctacagaaa cctaacgctg     5820

aagaaacctc aggagccaaa ctggtggaga aaacaaagag tcctccctct ctcccttttc     5880

aaataatgat catacatctt caagctgtct gaaatggtta aggagttcag tctgtcgtca     5940

ggcacacacc agagccagct agcccacaca gaccccatca gagcaaaaca gacaagagaa     6000

tttaattcat atccacatag aaaggacttc taggtaggag gtagaccctt tagctccctt     6060

ccaattaaag gagtccccaa ttctggcacc tgagagtccc ctgggtctaa cagctatgat     6120

atttatgtag tgtgttgctt acctaaatga atacaatttc cttccagaca cgtgacactg     6180

atattaaagt gctaatgaga gggatctatt tcttcttgta cgctaaaaga gaaacagcag     6240

ttcagatttc ccatcagaag tccgaggact ttgttcttga taactactac caataaaaat     6300

tgagtatttg                                                            6310


<210> 3457
<211> 2706
<212> DNA
<213> Homo sapiens

<400> 3457
gatgccaggc gagctgagct ggggatgctg gaacgaaggg cgttgctatg gcaacgggag       60

gcagggcctg gttgggggga ccgggcccgg gctgggaccg ggggggccgg cggtggctgt      120

ggtggggcga tggcggagcg cggcccggcc ttctgcggcc tgtacgacac gtcctcgctg      180

ctgcgatact gcaacgatga caatttgtcg ggcacgagcg gtatggaagt ggacgaccgc      240

gtgtcggcgc tggagcagcg gctgcagtta caggaagacg agctggcggt cctaaaggcg      300

gcgctggcgg atgctctgcg tcgcctgcgg gcatgcgaag aacagggagc ggcgctacgc      360

gcgcggggca cccccaaggg ccgggcgcct ccgcgcttag gcaccactgc ctcggtgtgt      420

cagctcttga aaggccttcc caccaggacg ccccttaatg gctcgggacc cccgcggcgc      480

gtgggtggct atgccacgtc cccatcctct cccaagaagg aggcgacctc cgggcgcagc      540

agtgtccgcc gctacttgtc accagagcgc ctcgcctcgg tgcgccgtga ggacccccgc      600

agccggacca catcctccag cagcaactgt agcgccaaaa aggaaggcaa aaccaaagaa      660

gttatcttca gtgtggagga tggctccgtg aaaatgttcc tgaggggccg ccctgtgccc      720

atgatgatcc cagacgagct ggcacccacc tacagcctgg acacacgctc ggagctgcct      780

tcttgccggc tcaagctgga gtgggtctat ggctaccgtg gccgagactg ccgggccaac      840

ctttatttgc tgcccaccgg ggagatagtg tactttgtgg cctccgtagc cgtgctatac      900

agcgtggagg agcagaggca gcgacactac ctgggacaca acgatgacat caaatgcttg      960

gccatccacc cagatatggt caccatcgcc acgggacagg tggcgggaac cactaaggaa     1020

gggaagccgc tgccgcccca cgtgcgcatc tgggactcag tttccctctc caccttacac     1080

gtgctgggct tgggggtgtt tgacagagcc gtgtgctgtg tgggcttctc caaatctaat     1140

ggaggcaacc tgctgtgtgc agtggatgaa tccaatgatc acatgctctc ggtgtgggac     1200

tgggccaagg agaccaaggt ggtggatgtc aagtgctcca atgaggctgt attggtggcc     1260

accttccacc ccacggaccc cactgtgctt atcacctgcg ggaaatctca catctacttc     1320

tggaccttgg aggggggcag cttgagcaag cggcaaggcc tctttgagaa acatgagaaa     1380

ccgaagtatg tgctgtgtgt gacctttttg gaaggtggcg acgtggtcac gggggactct     1440

ggggggaacc tctatgtttg gggcaaaggt gggaaccgta tcacacaggc ggtgctgggc     1500

gcccacgacg gcggcgtgtt tgggctctgc gccctgcggg acgggacgct ggtgtctgga     1560

gggggccgca attccatcct gcagggctcc gtgcacacag gcttctcact gctggtccag     1620

ggccatgtgg aagagctgtg gggcctggcc acacacccca gtcgggccca gtttgtgacc     1680

tgcgggcagg ataagctggt gcatctatgg agctcagatt cccaccagcc cctgtggagc     1740

aggatcatcg aggaccctgc ccgctcagcc ggcttccacc ccagtggctc tgtcctggct     1800

gtgggtacag tgactggcag atggctgctg ctggacacgg agacccatga cctggtggct     1860

atccacacag acggcaatga acagatctca gtggtcagct tctccccaga cggggcgtac     1920

ctggccgtgg gctcccacga caacttggtg tacgtgtaca cggtggacca gggcggccgc     1980

aaggtcagcc gcctgggcaa gtgctcgggc cattccagtt ttatcaccca cctggattgg     2040

gcccaggaca gcagctgctt tgtcaccaac tccggggact atgagattct gtactgggac     2100

ccggctacct gtaagcagat caccagtgcg gatgctgtga ggaacatgga atgggccaca     2160

gctacttgtg tcctagggtt tggggtgttt gggatctggt ctgagggggc ggacggcact     2220

gatatcaacg ctgtggcccg ctctcatgat gggaagttgc tggcttcagc tgatgacttt     2280

ggcaaagttc acctgtttag ctacccctgc tgtcagcctc gagccctcag ccacaagtac     2340

ggtggacaca gcagccatgt gacaaatgtg gccttcttgt gggatgacag catggccctg     2400

accacagggg gcaaggacac cagtgtgcta cagtggcggg tggtctgatg cggccaggga     2460

agagtcaggt gtcagggcag gaattctatt ttcgggagat gtctattgcc gagtagagta     2520

atatataccc agagtatgtc tatagcagag ggggttatgg gggcgggagg gtagactgac     2580

atacagaagt ctctatttat ccgggtggga agagggagtc acatcgcttt ggggatccat     2640

tggtgtttgg tttggggtgt tttttaagtt ttttctttta tatcatccag aaataaagac     2700

acgtac                                                                2706


<210> 3458
<211> 1916
<212> DNA
<213> Homo sapiens

<400> 3458
cactctgccc tgttgctgtc gcgccgctgc tggttgctgt ccctggaccc ctaccatgga       60

ggagaccatc aaagatcccc ccacatcagc tgtcttgctg gatcactgtc atttctctca      120

ggtcatcttt aacagtgtgg agaagttcta catccctgga ggggacgtca catgtcatta      180

taccttcacc cagcatttca tccctcgtcg aaaggattgg attggcatct ttagagcatt      240

taaatgtttc caagacaaat tggaacaaga actactcaaa tggaggagcc aaggacagaa      300

attgcaggtg gggtggaaga caacccgtga gtattacacc ttcatgtggg ttactttgcc      360

cattgaccta aacaacaaat cagctaaaca gcaggaagtc caattcaaag cttactacct      420

gcccaaggat gatgagtatt accagttctg ctatgtggat gaggatggtg tggtccgggg      480

agcaagtatt cctttccaat tccgtccaga aaatgaggaa gacatcctgg ttgttaccac      540

tcagggagag gtggaagaga ttgagcagca caacaaggag ctttgcaaag aaaaccagga      600

gctgaaggac agctgtatca gcctccagaa gcagaactca gacatgcagg ctgagctcca      660

aaagaagcag gaggagctag aaaccctaca gagcatcaat aagaagttgg aactgaaagt      720

gaaagaacag aaggactatt gggagacaga gctgcttcaa ctgaaagaac aaaaccagaa      780

gatgtcctca gaaaatgaga agatgggaat cagagtggat cagcttcagg cccagctgtc      840

aactcaagag aaagaaatgg agaagcttgt tcagggagat caagataaga cagagcagtt      900

agagcagctg aaaaaggaaa atgaccacct ctttctcagt ttaactgaac agaggaagga      960

ccagaagaag ctcgagcaga cagtggagca aatgaagcag aatgaaacta ctgcaatgaa     1020

gaaacaacag gaattaatgg atgaaaactt tgacctgtca aaaagactga gtgagaacga     1080

aattatatgt aatgctctgc agagacagaa agagagattg gaaggagaaa atgatctttt     1140

gaagagggag aacagcagat tgctcagtta catgggtctg gattttaatt ctttgccgta     1200

tcaagtacct acttcagatg aaggaggcgc aagacaaaat ccaggacttg cctatggaaa     1260

cccatattct ggtatccaag aaagttcttc ccccagcccg ctctccatca agaaatgccc     1320

tatctgcaaa gcagatgata tttgtgatca caccttggag caacagcaga tgcagcccct     1380

ttgtttcaat tgtccaattt gtgacaagat cttcccagct acagagaagc agatctttga     1440

agaccacgtg ttctgccact ctctctgagt atcccaacct cttggatgta tacagagatt     1500

ttatagaata gaacctatag cttctaccat gagttatatg agtcaagatc ctgcctaacc     1560

tgaaattatt agggatttac tcagccctgc tgccgctaac agtggagtta tgtcactgat     1620

ctgaaggtca ctgttaaggg cttctgctgc catccttgtg ggttgctacc tttaagtcgc     1680

ataactctag ctgtatcatc ctctcacctg tcattcttct gagggtctca gtacaagggc     1740

cctgggatgg agccaacctg ggtattcaca acaggcctga cttgatacta agtgattagt     1800

tttccaagtt gtcccactgc cattcaaagt cagcccttga gtgtatttgt tctcagtcct     1860

aaccctgggg ccagagattg gtccgaggtt gagaattcct tcctcctcat ccttgg         1916


<210> 3459
<211> 2200
<212> DNA
<213> Homo sapiens

<400> 3459
gacggccgcg catgcgccct tggttggcgg gagtttcgga ggcggtgacc gtgacgtaga       60

aggtggagac cgcttcaccc tgatcaggga gtatcggctg cgggtgcgca aggcgtccag      120

gagtgacctg gggctgtgga gagcgacccg tggccttgtg tttcagaaaa aggaccagtg      180

atgtctaaga ctcatgatca tcaattggaa tcaagtctca gtcctgtgga agtgtttgct      240

aaaacatctg cctccctgga gatgaatcaa ggcgtttcag aggaaagaat tcaccttggc      300

tctagcccta aaaaaggggg aaattgtgat ctcagccacc aggaaagact tcagtcgaag      360

tcccttcatt tgtctcctca agaacaatct gccagttatc aagacaggag gcaatcctgg      420

cggcgagcaa gtatgaaaga aacgaaccgg cggaagtcgc tgcatcccat tcaccagggc      480

atcacagagc tcagccggtc tatcagtgtc gatttagcag aaagcaaacg gcttggctgt      540

ctcctgcttt ccagtttcca gttctctatt cagaaacttg aacctttcct aagggacact      600

aagggcttca gtcttgaaag ttttagagcc aaagcatctt ctctttctga agaattgaaa      660

cattttgcag acggactgga aactgatgga actctacaaa aatgttttga agattcaaat      720

ggaaaagcat cagatttttc tttggaagca tctgtggctg agatgaagga atacataaca      780

aagttttctt tagaacgtca gacttgggat cagctcttgc ttcactacca gcaggaggct      840

aaagagatat tgtccagagg atcaactgag gccaaaatta ctgaggtcaa agtggaacct      900

atgacatatc ttgggtcttc tcagaatgaa gttcttaata caaaacctga ctaccagaaa      960

atattacaga accagagcaa agtctttgac tgtatggagt tggtgatgga tgaactgcaa     1020

ggatcagtga aacagctgca ggcctttatg gatgaaagta cccagtgctt ccagaaggtg     1080

tcagtacagc tcggaaagag aagcatgcaa caattagatc cctcaccagc tcgaaaactg     1140

ttgaagcttc agctacagaa cccacctgcc atacatggat ctggatctgg atcttgtcag     1200

tgactttatg agagtttctg ccacaaggtg cccaagagga gaggaatggg aagagtgccc     1260

cagcacgtgg tgactgcgtg atttctgctc gttgcctttg aagataactg gcaggactga     1320

ctgtagaaca ctttgacttt tttcaaaaag tgatggaatt tgtacatcca aatgaatatt     1380

gtatagacaa ttttcccagg aatgtgcaaa atgcttgaaa gttcaaactt cttttttgaa     1440

atgatcttca gatccagtgg cccattcttt tatctttatc ctgtgaaggt gtttttcagg     1500

ttttgaaaca atccaaaaat catttaggac caagtctaag gaaacatttt agtggccaag     1560

ttggattccg attgtaaagg aatgatacta attttctagc atggctctga aggtgatttt     1620

aggtagaaga gttttgaggc tgggcgcaat ggctcacgcc tgtaatccta gcattttggg     1680

tgactgaggc gggtggattg cttgagccca gaagttgaag accagcctga gaaataaggt     1740

gaaaccctgt ctacaaaaaa tacaaaaagt tagctgggtg tggtggcgtg tgcctgtagt     1800

gctagctact cagaaggctg aggtgggagg attgtttgag cccaggaggt tgaggctgca     1860

gtgagttcta attgcgccac tgcactccag cctgagcgac agagtgagac actgtcttaa     1920

aaaaaattaa aaattgtaaa aaaatgaaaa aaaaagtttt gagcattatt tgcatcattg     1980

ggatacatat gtcacttcac aagatgttca atttgaagga aataccactc attctctatg     2040

tcctgttgtc tgtagtgtgc ttcagttttt catattgagt tgacctaaat cctggattca     2100

tgacaagaaa ggagtaagta ctactattca ttgttctatt tgtttataat ctgtattata     2160

aaattgcaca taattaaaag ctttcccttg tcttcatcta                           2200


<210> 3460
<211> 1780
<212> DNA
<213> Homo sapiens

<400> 3460
agcggaaaac caattggttt aaaagaagag ccagtaagtt catgactcac gtggcctccc       60

agtttgcctc cagctatgtg ttttattggc gggattactt tgaggaccag ccccttctgt      120

atcccccagg ctttgacgga agagtcgtgg tgtatcccag caaccagact ttaaaggact      180

acctcagctg gcgacaagca gattgtcaca tcaataatct ttataataca gttttctggg      240

cacttataca acaatctgga ctaacaccag tacaagccca agggagatta cagggaactc      300

ttgcagcaga caagaatgag attttgtttt ctgaattcaa catcaactat aataatgagc      360

tgccgatgta taggaaaggg actgtgttga tatggcagaa ggtggatgaa gtgatgacaa      420

aagaaattaa gctgccaaca gaaatggaag gaaaaaagat ggcagtgacc cggaccagga      480

caaagccagt gcccttgcac tgcgatatca tcggggatgc tttctggaag gaacatccag      540

agattctaga tgaagacagc tgaccctttt gcgcttcagt tctggtgtgc ttaaccatgc      600

aagccctccc acctcccagg acactggtgc gaatgacaca actcaagttg ggaggggaac      660

agggaaggaa gggatggatg ggggtggtgt atcttactct gtttaagcag aacaccttgt      720

ttgcggtgtt ggaacatggt tcctttggca gaagtgcttt ttttttaatc gcagtactat      780

ttttataaag caagaactat tccatgcctt ggagaatgaa tcatttttag attgtgacat      840

aaatcttgta aaaacctgtc agttattttc atctatgaga gaagaggagc ccaaactctc      900

gcccacctgt tcttaaccag aaaacccact gactttgaaa atctcacctc tgccacccat      960

ctacttgcat tcgtctttgg cagacctcaa gataaatatg ggttaatgcc tgcatgatgc     1020

ctctgaattc aggaattgca gggaaaactc ggggctttgt gccagtctct aagttggcaa     1080

ctttggctga acaaatgagt agtggcttca gtgtccttgc gtacacattc tgtggattga     1140

tttaatggag ttgtcagcat gatcatcatc ttctagccag gggcatagtt gccaaggcca     1200

tttacctctt tctaagaaga aacagaatta tgtgtatata tgagagaaag aaacaagaat     1260

gcgtgaatga ggatgaagaa acatttaccc catgtactca agacatttca gttttaaaag     1320

tcactttcct attagacttc ttgaaaaaca ttctcacata gcctctatgt aatcagacaa     1380

atgacatttg atttcaagag cagaggggta aacatcctct gctaatcgac aggtagcagg     1440

tgtcagagga ggcataatat taatagcgcc accttctgtt gggtcagtgg agatgggtga     1500

ggaacagcac agagcagcag ggatcatcac atgcagccaa acttggcctc tgaaggggga     1560

aggtagtggg aataggtggt gagagaactc acatttttct cttgtcctgg ttttatattt     1620

cggagggaaa ggattatttg gccccattaa gaattaagag gctgggtgcg gtggctcacg     1680

tctgtaatcc cagcaccttg ggaggcccag gcaggcagat cacctgaggt cgggagttcg     1740

agaccagcgt gaccaacgtg gagaaacccc cgtctctact                           1780


<210> 3461
<211> 558
<212> DNA
<213> Homo sapiens

<400> 3461
gaaatttggg ttttaggaca ggcgaaccaa cccgctctcc ttcaagctcc cggccatttc       60

ttggggcaga gagctaggag gggtccgcgg cagagcaaag cgggaaggcc caatgggcag      120

gaagcctctc cagccgcccc cagcccggcc ggcccccgca cgccccagag cctcaattga      180

cttggatttc cttgagttcg gtgtctaggg agccaagtgt tgggctgtgg aaggtagatg      240

aatgctccag ggatagagac ctgtatcagg gtgccatgga gatggagagc gcggcggcct      300

ccacacgttt ccaccagcct cacatggaga ggaagatgag tgcgatggcc tgtgagatct      360

tcaacgagct tagactagag ggcaagctct gcgacgtggt catcaaggtc aatggctttg      420

agttcagtgc ccataagaac atcctctgta gctgcagttc ctactttaga gctttgttta      480

caagtggctg gaacaacact gaaaagaagg tatacaacat ccctggcatt tctcccgaca      540

tgatgaagct aatcattg                                                    558


<210> 3462
<211> 2062
<212> DNA
<213> Homo sapiens

<400> 3462
gtgtttcacc acacggagat gtggtcacgt gacttgtcaa ctttcaccca ggatgtctcc       60

cttctgactt ccccttagca accaagtcgc ggcgcttggt tccccagcaa ccgggagacg      120

cgtctgctgc gtggaaccgc cgagttccca gcgcttgaga aggaaaattc tggatctgtt      180

atctgtgagg aggccactcc gttgacagtt gtgtaaaact ctgctgcttt ccccagctcc      240

aacctctctg gtcttcaaca acactatcat cagggaaaac gtgggggaag atgaaccagc      300

cgtgcaactc gatggagccg agggtgatgg acgatgacat gctcaagctg gccgtcgggg      360

accagggccc ccaggaggag gccgggcagc tggccaagca ggagggcatc ctcttcaagg      420

atgtcctgtc cctgcagctg gactttcgga acatcctccg catagacaac ctctggcagt      480

ttgagaactt gaggaagctg cagctggaca ataacatcat tgagaagatc gagggcctgg      540

agaacctcgc acacctggtc tggctggatc tgtctttcaa caacattgag accatcgagg      600

ggctggacac actggtgaac ctggaggacc tgagcttgtt caacaaccgg atctccaaga      660

tcgactccct ggacgccctc gtcaagctgc aggtgttgtc gctgggcaac aaccggattg      720

acaacatgat gaacatcatc tacctccggc ggttcaagtg cctgcggacg ctcagcctct      780

ctaggaaccc tatctctgag gcagaggatt acaagatgtt catctgtgcc taccttcctg      840

acctcatgta cctggactac cggcgcattg atgaccacac aaaaaagctt gcggaggcta      900

agcaccagta cagcatcgac gagctgaagc accaggagaa cctgatgcag gcccagctgg      960

aggacgagca ggcgcagcgg gaggagctag agaagcacaa gactgcgttt gtggaacacc     1020

tgaatggctc cttcctgttt gacagcatgt acgctgagga ctcagagggc aacaatctgt     1080

cctacctgcc tggtgtcggt gagctccttg agacctacaa ggacaagttt gtcatcatct     1140

gcgtgaatat ttttgagtat ggcctgaaac agcaggagaa gcggaaaaca gagcttgaca     1200

ccttcagtga atgtgtccgt gaggccatcc aggaaaacca ggagcagggc aaacgcaaga     1260

ttgccaaatt cgaggagaag cacttgtcga gtttaagtgc cattcgagag gagttggaac     1320

tgcccaacat tgagaagatg atcctagaat gcagtgctga catcagtgag ttgttcgatg     1380

cgctcatgac gctggagatg cagctggtgg agcagctgga ggagactata aacatgtttg     1440

aaaggaacat tgttgacatg gtaggactgt ttatcgaaaa tgtccaaagc ctgatggctc     1500

agtgccggga cctggagaat caccaccacg agaagctcct ggagatctct atcagcaccc     1560

tggagaagat tgtcgagggc gacctggacg aggacctgcc taacgacctg cgcgcgcttt     1620

ttgtcgataa agatacgatt gttaatgctg tcggggcatc gcacgacatc cacctcctga     1680

agattgacaa tcgagaagat gagctggtga ccagaatcaa ctcttggtgt acacgtttaa     1740

tagacaggat tcacaaggat gagatcatga ggaaccgcaa gcgcgtgaag gagatcaatc     1800

agtacatcga ccacatgcag agcgaactgg acaacctgga atgtggcgac atcctagact     1860

agatgaatgt cagccacagg agcttcttca aaacatagca ccagccccag ccaggagaag     1920

gaagtgcaca cgcctcaccc gcacctctag agagttgctg ggcatctctc aaccgcgatc     1980

cccaacacca ttcttccccc acccctggaa aaacttccaa aagtagagaa aataaaggac     2040

tcatttcaca tttcccctac tc                                              2062


<210> 3463
<211> 1332
<212> DNA
<213> Homo sapiens

<400> 3463
gcacaaattc gcagcaggcg gctggggcgg cggctggggc agcggctgca gcagcggcgg       60

acgctctgca ttacccagtc ttgcgtcctc ggcaggcgcc cgaagctgag tgcgcatcct      120

ctaccgcacc caagcttcgt ctgtctcgtc aagctcttca tgctgcccaa ctaaaaggaa      180

aacatgggca caggggattt tatctgcatt tccatgactg gaggggcgcc ctgggggttc      240

agattgcaag gtggcaagga gcagaagcag cccttacaag ttgcaaagat tcgaaatcag      300

agcaaagcct ctgggtctgg gctctgtgag ggagatgaag tggtttccat caatggcaac      360

ccttgtgcag atctcaccta ccctgaagtc atcaagctca tggaaagcat aacagactct      420

ctccaaatgc tcatcaaaag gagagtgggc gctccctttc tcttcctgga agatcagtcc      480

caccccccat ttctacatct ccttgggtat accagcctac ttatagttac tctagtaaac      540

caaccgatgg actagagaaa gcaaacaaga gaccaactcc ttgggaagca gcagcaaagt      600

ctcctctcgg tctagtggat gatgctttcc aacccagaaa catccaggaa tccattgtgg      660

caaatgtggt ttcagcagct cggaggaagg tgcttccagg gcctccagag gattggaatg      720

aaagactgtc ctatattcct caaacccaga aggcctatat gggctcatgt ggaaggcaag      780

agtataatgt cacagccaat aataatatgt ccaccacctc ccaatatggt tcacagttgc      840

catatgcata ttataggcag gcttcaagaa atgattctgc aatcatgtcc atggaaacca      900

ggtctgatta ctgtcttcca gtagctgatt acaactacaa cccacaccca aggggatgga      960

gacgccaaac atgaaagtta gaagaacgga tcatgtgcca actgtagttt tttaaaaaaa     1020

acgctccttt gtagggtttt aaacttttct aatagattta gattcacttt tggtcttggc     1080

ttgttctcat aagtcattta tctaagtttg tgtttctgtg tgtgtgtgtg tgtgtgtatg     1140

tatgtgaata tacacacaca cacacacaca ggtgagtgtg aatacttcct tgttggctga     1200

tccatagagc attacttgga agaaaatttc actatttgca ttgatgtgct ggcatttata     1260

tgtaattcat aattttgatt ccattaatag gtagtctatg caacaaactc tactcaatta     1320

aagtaaaact aa                                                         1332


<210> 3464
<211> 1445
<212> DNA
<213> Homo sapiens

<400> 3464
cgctcccgtt gctaccggaa tgcctcttca ggttagcgat tacagctggc agcagacgaa       60

gactgcggtc tttctgtctc tgcccctcaa aggcgtgtgc gtcagagaca cggacgtgtt      120

ctgcacggaa aactatctga aggtcaactt tcctccattt ttatttgagg catttcttta      180

tgctcccata gacgatgaga gcagcaaagc aaagattggg aatgacacca ttgtcttcac      240

cttgtataaa aaagaagcgg ccatgtggga gaccctttct gtgacgggtg ttgacaaaga      300

gatgatgcaa agaattagag aaaaatctat tttacaagca caagagagag caaaagaagc      360

tacagaagca aaagctgcag caaagcggga agatcaaaaa tacgcactaa gtgtcatgat      420

gaagattgaa gaagaagaga ggaaaaaaat agaagatatg aaagaaaatg aacggataaa      480

agccactaaa gcattggaag cctggaaaga atatcaaaga aaagctgagg agcaaaaaaa      540

aattcagaga gaagagaaat tatgtcaaaa agaaaagcaa attaaagaag aaagaaaaaa      600

aataaaatat aagagtctta ctagaaattt ggcatctaga aatcttgctc caaaagggag      660

aaattcagaa aatatattta ctgagaagtt aaaggaagac agtattcctg ctcctcgctc      720

tgttggcagt attaaaatca actttacccc tcgagtattc ccaacagctc ttcgtgaatc      780

acaagtagca gaagaggagg agtggctaca caaacaagct gaggcacgaa gagcaatgaa      840

tactgacata gctgaacttt gcgatttaaa agaagaagaa aagaacccag aatggttgaa      900

ggataaagga aacaaattgt ttgcaacgga aaactatttg gcagctatca atgcatataa      960

tttagccata agactaaata ataagatgcc actattgtat ttgaaccggg ctgcttgcca     1020

cctaaaacta aaaaacttac acaaggctat tgaagattct tctaaggaat tctgttctct     1080

tgagggcatt gaatgtcagg cctctgagcc caagctaagc catcatatcc ctagtgacct     1140

gcacgtatac atccagatgg cctgaagcaa gtgaagaatc acaaaagaag tgaaaatggc     1200

cggttcctgc cttaactgat gacattacct tgtgaaattc cttctcctgg ctcagaacct     1260

cccccactga gcaccttgtg acccctgccc ctgcccgcca cagaataacc ccctttgact     1320

gtaattttcc attacctacc caaatcctat aaaacggccc cacccctatc tcccttcgct     1380

gactgtcttt tcggactcag cccgcctcca cccaggtgat taaaaagctt tattgctcac     1440

acaaa                                                                 1445


<210> 3465
<211> 1021
<212> DNA
<213> Homo sapiens

<400> 3465
acatccgggt accgactcca gccgcctaga cgctggcact atggtcatgg cggaggggac       60

ggcagtgctg aggcggaaca ggccgggcac caaggcgcag tatattcaac agaacataag      120

agcagattgc tccaatattg acaaaattct tgaaccacct gaaggccaag atgaaggtgt      180

gtggaagtat gaacatttaa ggcagttctg ccttgagcta aatggacttg ctgtcaaact      240

tcagagtgaa tgccatccag atacttgcac tcaaatgaca gcaactgaac aatggatttt      300

tctttgtgca gctcataaaa ctccaaaaga gtgtcctgct atagactata ctagacacac      360

acttgatggt gctgcatgtc ttctgaatag caataaatat tttcccagca gggttagcat      420

aaaggaatca tctgtagcga aactaggatc agtatgccgt aggatttaca gaatattttc      480

acatgcttat tttcatcatc ggcagatatt tgatgaatat gaaaatgaaa catttttgtg      540

tcatcggttt actaagtttg tgatgaaata caatttgatg tccaaggata acctgattgt      600

accaatttta gaagaggaag tacagaattc agtttctggg gaaagtgaag catgaaggga      660

atcataggaa aaatgtactg atcatataat taacattatg tactgtatat atcattttag      720

acacatcaat catgtatcca tattatagct tctttgttta gtataggttt ttgtatgctg      780

ggtttgcctt ttaaaatggg aaatactttt taagttattc ataagctgta tattcaccag      840

tgtggcactc atggttttta aataagatta gtattatctg tttataatgc ctgttaataa      900

aagaatttac agtttggtaa aattgctgct aaacaatcat tggatcacaa tcctcatcag      960

acaaacccat ctgtaaaaaa aatgagggag agcttgaggt ttcacacaag ccatttacta     1020

a                                                                     1021


<210> 3466
<211> 1808
<212> DNA
<213> Homo sapiens

<400> 3466
gtttccggtt gtcggaggcg aggcttgtcg gctgtcaaag gggcggcccg gcccggcccg       60

gaagctacag cagcggcgcg gagactgcgg ggcgggccat ggcggcgaac ctgagccgga      120

acgggccagc gctgcaagag gcctacgtgc gggtggtcac cgagaagtcc ccgaccgact      180

gggctctctt tacctatgaa ggcaacagca atgacatccg cgtggctggc acaggggagg      240

gtggcctgga ggagatggtg gaggagctca acagcgggaa ggtgatgtac gccttctgca      300

gagtgaagga ccccaactct ggactgccca aatttgtcct catcaactgg acaggcgagg      360

gcgtgaacga tgtgcggaag ggagcctgtg ccagccacgt cagcaccatg gccagcttcc      420

tgaagggggc ccatgtgacc atcaacgcac gggccgagga ggatgtggag cctgagtgca      480

tcatggagaa ggtggccaag gcttcaggtg ccaactacag ctttcacaag gagagtggcc      540

gcttccagga cgtgggaccc caggccccag tgggctctgt gtaccagaag accaatgccg      600

tgtctgagat taaaagggtt ggtaaagaca gcttctgggc caaagcagag aaggaggagg      660

agaaccgtcg gctggaggaa aagcggcggg ccgaggaggc acagcggcag ctggagcagg      720

agcgccggga gcgtgagctg cgtgaggctg cacgccggga gcagcgctat caggagcagg      780

gtggcgaggc cagcccccag aggacgtggg agcagcagca agaagtggtt tcaaggaacc      840

gaaatgagca ggagtctgcc gtgcacccga gggagatttt caagcagaag gagagggcca      900

tgtccaccac ctccatctcc agtcctcagc ctggcaagct gaggagcccc ttcctgcaga      960

agcagctcac ccaaccagag acccactttg gcagagagcc agctgctgcc atctcaaggc     1020

ccagggcaga tctccctgct gaggagccgg cgcccagcac tcctccatgt ctggtgcagg     1080

cagaagagga ggctgtgtat gaggaacctc cagagcagga gaccttctac gagcagcccc     1140

cactggtgca gcagcaaggt gctggctctg agcacattga ccaccacatt cagggccagg     1200

ggctcagtgg gcaagggctc tgtgcccgtg ccctgtacga ctaccaggca gccgacgaca     1260

cagagatctc ctttgacccc gagaacctca tcacgggcat cgaggtgatc gacgaaggct     1320

ggtggcgtgg ctatgggccg gatggccatt ttggcatgtt ccctgccaac tacgtggagc     1380

tcattgagtg aggctgaggg cacatcttgc ccttcccctc tcagacatgg cttccttatt     1440

gctggaagag gaggcctggg agttgacatt cagcactctt ccaggaatag gacccccagt     1500

gaggatgagg cctcagggct ccctccggct tggcagactc agcctgtcac cccaaatgca     1560

gcaatggcct ggtgattccc acacatcctt cctgcatccc ccgaccctcc cagacagctt     1620

ggctcttgcc cctgacagga tactgagcca agccctgcct gtggccaagc cctgagtggc     1680

cactgccaag ctgcggggaa gggtcctgag caggggcatc tgggaggctc tggctgcctt     1740

ctgcatttat ttgccttttt tctttttctc ttgcttctaa ggggtggtgg ccaccactgt     1800

ttagaatg                                                              1808


<210> 3467
<211> 3573
<212> DNA
<213> Homo sapiens

<400> 3467
agtgctcagc aacgattacg ccccgagggc caatcacagg gctgcggccg agagagaagc       60

cttattagag ctttctcaac ctgcagccct catctccgcc ggcgagtagg gccaggtgtt      120

gggagctccc acgtgggaca agatggtgtc ttcggcgcag atgggcttca acctgcaggc      180

tctcctggag cagctcagcc aggatgagtt gagcaagttc aagtatctga tcacgacctt      240

ctccctggca cacgagctcc agaagatccc ccacaaggag gtagacaagg ctgatgggaa      300

gcaactggta gaaatcctca ccacccattg tgacagctac tgggtggaga tggcgagcct      360

ccaggtcttt gaaaagatgc accgaatgga tctgtctgag agagcaaagg atgaagtcag      420

agaagcagct ttgaaatcct ttaataaaag gaagcctcta tcattaggga taacacggaa      480

agaacgacca cctctagacg tggacgaaat gctggagcgc ttcaaaacag aagcacaagc      540

gtttacagaa acgaaaggaa atgtcatctg cctgggtaaa gaagtcttta aaggaaaaaa      600

gccagacaaa gacaataggt gcaggtatat attgaagacg aagttccggg agatgtggaa      660

gagctggcct ggagatagca aagaggtcca ggttatggct gagagataca agatgctgat      720

cccattcagc aaccccaggg tgcttcccgg gcccttctca tacacggtgg tgctgtatgg      780

tcctgcaggc cttgggaaaa ccacgctggc ccagaaacta atgctagact gggcagagga      840

caacctcatc cacaaattca aatatgcgtt ctacctcagc tgcagggagc tcagccgcct      900

gggcccgtgc agttttgcag agctggtctt cagggactgg cctgaattgc aggatgacat      960

tccacacatc ctagcccaag cacggaaaat cttgttcgtg attgacggct ttgatgagct     1020

gggagccgca cctggggcgc tgatcgagga catctgcggg gactgggaga agaagaagcc     1080

ggtgcccgtc ctcctgggga gtttgctgaa cagggtgatg ttacccaagg ccgccctgct     1140

ggtcaccacg cggcccaggg ccctgaggga cctccggatc ctggcggagg agccgatcta     1200

cataagggtg gagggcttcc tggaggagga caggagggcc tatttcctga gacactttgg     1260

agacgaggac caagccatgc gtgcctttga gctaatgagg agcaacgcgg ccctgttcca     1320

gctgggctcg gcccccgcgg tgtgctggat cgtgtgcacg actctgaagc tgcagatgga     1380

gaagggggag gacccggtcc ccacctgcct cacccgcacg gggctgttcc tgcgtttcct     1440

ctgcagccgg ttcccgcagg gcgcacagct gcggggcgcg ctgcggacgc tgagcctcct     1500

ggccgcgcag ggcctgtggg cgcagacgtc cgtgcttcac cgagaggatc tggaaaggct     1560

cggggtgcag gagtccgacc tccgtctgtt cctggacgga gacatcctcc gccaggacag     1620

agtctccaaa ggctgctact ccttcatcca cctcagcttc cagcagtttc tcactgccct     1680

gttctacacc ctggagaagg aggaggaaga ggatagggac ggccacacct gggacattgg     1740

ggacgtacag aagctgcttt ccggagtaga aagactcagg aaccccgacc tgatccaagc     1800

aggctactac tcctttggcc tcgctaacga gaagagagcc aaggagttgg aggccacttt     1860

tggctgccgg atgtcaccgg acatcaaaca ggaattgctg cgatgcgaca taagttgtaa     1920

gggtggacat tcaacggtga cagacctgca ggagctcctc ggctgtctgt acgagtctca     1980

ggaggaggag ctggtgaagg aggtgatggc tcagttcaaa gaaatatccc tgcacttaaa     2040

tgcagtagac gttgtgccat cttcattctg cgtcaagcac tgtcgaaacc tgcagaaaat     2100

gtcactgcag gtaataaagg agaatctccc ggagaatgtc actgcgtctg aatcagacgc     2160

cgaggttgag agatcccagg atgatcagca catgcttcct ttctggacgg acctttgttc     2220

catatttgga tcaaataagg atctgatggg tctagcaatc aatgatagct ttctcagtgc     2280

ctccctagta aggatcctgt gtgaacaaat agcctctgac acctgtcatc tccagagagt     2340

ggtgttcaaa aacatttccc cagctgatgc tcatcggaac ctctgcctag ctcttcgagg     2400

tcacaagact gtaacgtatc tgacccttca aggcaatgac caggatgata tgtttcccgc     2460

attgtgtgag gtcttgagac atccagaatg taacctgcga tatctcgggt tggtgtcttg     2520

ttccgctacc actcagcagt gggctgatct ctccttggcc cttgaagtca accagtccct     2580

gacgtgcgta aacctctccg acaatgagct tctggatgag ggtgctaagt tgctgtacac     2640

aactttgaga caccccaagt gctttctgca gaggttgtcg ttggaaaact gtcaccttac     2700

agaagccaat tgcaaggacc ttgctgctgt gttggttgtc agccgggagc tgacacacct     2760

gtgcttggcc aagaacccca ttgggaatac aggggtgaag tttctgtgtg agggcttgag     2820

gtaccccgag tgtaaactgc agaccttggt gctttggaac tgcgacataa ctagcgatgg     2880

ctgctgcgat ctcacaaagc ttctccaaga aaaatcaagc ctgttgtgtt tggatctggg     2940

gctgaatcac ataggagtta agggaatgaa gttcctgtgt gaggctttga ggaaaccact     3000

gtgcaacttg agatgtctgt ggttgtgggg atgttccatc cctccgttca gttgtgaaga     3060

cctctgctct gccctcagct gcaaccagag cctcgtcact ctggacctgg gtcagaatcc     3120

cttggggtct agtggagtga agatgctgtt tgaaaccttg acatgttcca gtggcaccct     3180

ccggacactc aggttgaaaa tcgatgactt taatgatgaa ctcaataagc tgctggaaga     3240

aatagaagaa aaaaacccac aactgattat tgatactgag aaacatcatc cctgggcaga     3300

aaggccttct tctcatgact tcatgatctg aatccccccg agtcattcat tctccatgaa     3360

gtcatcgatt ttccaggtgt tggtgaactg cctgtgactc ctctcctccc cggcccctac     3420

ccctcaggga taatgagttc attgctgggc tagatgtttt agccatgatt ctgcctctgt     3480

tttatacctg cacacatcct tatctttgtt acatatgaaa tatctgtatc acgggtatat     3540

tgagagaaat aaaggtgaga gcattcacaa atg                                  3573


<210> 3468
<211> 521
<212> DNA
<213> Homo sapiens

<400> 3468
gtttattact actgaaggaa gaacgtgagt agatcagaaa agggagctca ggtaccttcc       60

agagagtgag acccagcgcc cttgtctcgc acccagtagg ctttcatccc cgccatggcg      120

gagctgatcc agaagaagct acagggagaa gtggagaaat atcaacagct acagaaggac      180

ttaagtaaat ccatgtcggg gaggcagaaa cttgaagcac aactaacaga aaataatatc      240

gtgaaagagg aactggccct gctggatggg tccaacgtgg tctttaaact tctgggtccg      300

gtgctagtca aacaggagct gggggaggct cgggccacag tagggaagag gctggactat      360

atcacagctg aaattaagcg atacgaatcc cagcttcggg atcttgagcg gcagtcagag      420

caacagaggg agacccttgc tcagctgcag caggagttcc agcgggccca ggcagcaaag      480

gcaggggctc ctggcaaggc ctgaccccat ggtgggggga g                          521


<210> 3469
<211> 614
<212> DNA
<213> Homo sapiens

<400> 3469
gtacaacttc cggctgtaaa gatggcggct tcctagtgag tcggcggctg atttagaagg       60

aggttcaggc tacggtgagc cgaagccaca caggagccat ggaagtggca gagcccagca      120

gccccactga agaggaggag gaggaagagg agcactcggc agagcctcgg ccccgcactc      180

gctccaatcc tgaaggggct gaggaccggg cagtaggggc acaggccagc gtgggcagcc      240

gcagcgaggg tgagggtgag gccgccagtg ctgatgatgg gagcctcaac acttcaggag      300

ccggccctaa gtcctggcag gtgcccccgc cagcccctga ggtccaaatt cggacaccaa      360

gggtcaactg tccagagaaa gtgattatct gcctggacct gtcagaggaa atgtcactgc      420

caaagctgga gtcgttcaac ggccagcaga aaactgagct tccggtcaca gagaacgtgc      480

agacgattcc cccgccatat gtggtccgca ccatccttgt ctacagccgt ccaccttgcc      540

agccccagtt ctccttgacg gagcccatga aggtgggtga ggcctgggag agggaggggt      600

gcctgcagcc atga                                                        614


<210> 3470
<211> 3549
<212> DNA
<213> Homo sapiens

<400> 3470
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact     1560

catatcaacc caagtaccat gtggacttga tccctggctg aatcacctgg atgacttgga     1620

atagaaatga ctgctttaga agatgggatg gggccgggtg gtgagggata gaagagagga     1680

ctctcaatct actgatcaag tcctttcccc aatgcccagt ggatggccag ggtacctggg     1740

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1800

tagaaagagc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1860

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1920

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1980

agtgtggtgg ccactggtga cttgaaaatg tagagaaaaa aaaaacctgc tctatatctg     2040

aaagagctct tgggaagaca gagaaacata aagaggaaat tatagcacag tgtggtgggt     2100

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     2160

ggaaggagag gatgagtggg ggatggcttt ctgaaaaggg tagtctaaag gatgcctata     2220

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     2280

ggatgacctg tgactctgga gcactgggtt gtctccattg tccttatggg cagatgtgtg     2340

ccatccccag ccgacaccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     2400

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     2460

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     2520

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2580

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaccttta     2640

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2700

ggaagagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2760

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gatgtaaaat     2820

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2880

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2940

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     3000

aagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     3060

aaaatacaga cacacacaag tgcctatata atgataaaac atatgcaaag cacccaaacc     3120

tgtgattcca gaaaggtaga tcctattttt ctgtttattt ttattggctt tagctgtgtc     3180

ttttgaaagg actattatcc tctaaaatgt atgtgtatga agatcctggc ttgcagctcg     3240

ggagctttac acaccttgtg tcactttatc ttggtaacga gccaagatca tgcaaccagt     3300

tcatccatgt ctgacccaag agctcttaac tgctatgctg cactgcctca ttcagagata     3360

gatgcctgca tgggtcctgg cgattatttt aatgctggct acacccccac aggtgacttg     3420

gattcagaaa tacaatttat atttcttctt tttaaattgt tttattttat ttttctttta     3480

atagttatat gtcagtgaga acaatttata tgtcttacac tgagaaataa aactgctcat     3540

aagtgaaaa                                                             3549


<210> 3471
<211> 4356
<212> DNA
<213> Homo sapiens

<400> 3471
aagcagatag gtttcagaga taaagagtga aaccaaaaac accgcacacc tcatccaaat       60

ctgcgctcat acttgcagca aatgtttgct gtcagttgct tcataataac agcacagacc      120

ccgaattgca ggaggaattg cctggtagaa aactgaagac tttaataaca aactctccaa      180

ggtgaaaatg aacacagggc gtgattctca gtcaccagac tcagcttgga gatcttacaa      240

tgatggcaat caggagacac tgaacggaga tgctacatat tcctctcttg cagcaaaagg      300

ttttagaagc gttcgaccaa acctacaaga taaaagatca ccaactcaga gccagataac      360

agtgaatgga aactcaggag gtgccgtgag tcccatgagt tactatcaga ggccgttttc      420

cccctcggca tattctctcc cagcctcact caactccagc attgtcatgc agcacggcac      480

atccctcgat tccacagaca catatcccca gcatgcgcag tctctggatg gcaccaccag      540

cagctctatc cccctgtacc gatcctcaga ggaagagaag agagtgacag tcatcaaagc      600

cccgcattac ccagggatcg ggcccgtgga tgaatccgga atccccacag caattagaac      660

gacagtcgac cggcccaagg actggtacaa gacgatgttt aagcaaattc acatggtgca      720

caagccggat gatgacacag acatgtataa tactccttat acatacaatg caggtctgta      780

caacccaccc tacagtgctc agtcacaccc tgctgcaaag acccaaacct acagacctct      840

ttccaaaagc cactccgaca acagccccaa tgcctttaag gatgcgtcct ccccagtgcc      900

tcccccacat gttccacctc cagtcccgcc gcttcgacca agagatcggt cttcaacaga      960

aaagcatgac tgggatcctc cagacagaaa agtggacaca agaaaatttc ggtctgagcc     1020

aaggagtatt tttgaatatg aacctggcaa gtcatcaatt cttcagcatg aaagaccacc     1080

tcctaaaaag cctctggact atgttcaaga tcattcttct ggtgttttca atgaggcctc     1140

cttgtatcag tcctctatag acagaagcct ggaaagaccc atgagttctg caagcatggc     1200

cagtgacttc aggaagcgga ggaagagcga gcctgcagtg ggtccaccac ggggcttggg     1260

agatcaaagt gcgagcagga ctagcccagg ccgagtggac ctcccaggat caagcaccac     1320

tcttacaaag tctttcacta gctcttctcc ttcttcccca tcaagagcaa aagaccgtga     1380

gtcccctaga agttactcat ccactttgac tgacatgggg agaagtgcac caagggaaag     1440

aagaggaact ccagaaaaag agaaattgcc tgcaaaagct gtttatgatt ttaaggctca     1500

gacatctaag gagttgtcat ttaagaaagg agatactgtc tacatcctca ggaaaattga     1560

tcaaaattgg tatgagggag aacaccacgg gagagtgggc atcttcccga tctcatacgt     1620

agagaaactc acacctcctg agaaagcaca gcctgcaaga ccacctccgc cagcccagcc     1680

cggagaaatc ggagaagcta tagccaaata caacttcaac gcagacacaa atgtggagct     1740

gtcactgaga aagggagata gagttattct tcttaaaaga gttgatcaaa actggtatga     1800

aggtaaaatc ccaggaacca acagacaagg catcttccct gtttcctatg tggaggtcgt     1860

caagaagaac acaaaaggtg ctgaggacta ccctgaccct ccaatacccc acagctattc     1920

tagtgatagg attcacagct tgagctcaaa taagccacag cgtcctgtgt ttactcatga     1980

aaatattcaa ggtggggggg aaccgtttca ggctctgtat aactatactc ccaggaatga     2040

agatgagctg gagctcagag aaagtgatgt cattgatgtc atggaaaagt gtgatgacgg     2100

ctggtttgtg gggacctcaa gaagaaccaa attctttggt actttccccg gaaactacgt     2160

caagaggctg tgaattgcgc tccctccttc tgtagaggcc gcctgccagc catgcacctg     2220

cgtcaacgcg cctgaaacac cccgcgggcc tcccgttgtc atgccttacg gtttccaatg     2280

cgccgtcacc atctccacct gccaccaaac caccagcaga gtagccgccg ctgctgtgag     2340

cctggggacg acatggcagg ctggtccccc tccgtgaaag tgtggattcc tacttcctgc     2400

tctaagcttt gacacgtcaa aatgtgggat cagaaagaaa aaaatcatga tatttaaaaa     2460

tggtcaaata tttgaggcaa aaaaaaaaaa aaaaagtgtc tccaggaggc tgtccagcct     2520

cgtggctcca tttcaacatc tccccccagg cgatgttctc ccccaagacg accagaaaat     2580

tgtttattgg ggaatgctgt ggtttgcatt ttcatattct tcgcttggca gtgtgtattc     2640

ttttcacaag tttgcctagt gtcttggttt acacaatatg acaactgtaa ctgtacttta     2700

gctattgttt gcctgcacat acatgttgta atatgcacag tgattacaac ctttaaagca     2760

agaggaggcg agttaatttg gatgagtgtg attttgctga ttgaatgtga gttttcaaat     2820

aggagtcttt ttctgcaatt tgtttgcatt ttttagaagt gcaaacagta agtaaataaa     2880

agccttcggt aataatcatg acaatacaag aggctgagct aggctacagg ggaaaactat     2940

tgtgttgtaa agttgcatcg ctattttata ttaaaatgta atgatcagca tcatgaacaa     3000

tgagctctta gtgttttatt tatctgaaaa aatgtaagta aaagcagtgt tagtgagagg     3060

tgcaaagaat tattctaaca gacacctgaa agtatctgta agcaatacta gtaggtaaga     3120

tttcactgtg tgtacacata cacatttgag attgtatgag aacatataat ccatatgata     3180

tgttgtacat tttatggaaa tgtaatagaa tctcacacat tattttatag aaatagagta     3240

cagaagcatc acaagtatta aagttggttt tagcaaggat taggattact acaattattt     3300

ttactataat aattattttt cttctatgga actcagaatc ctggctacat ttgaggacag     3360

gaatatgttg agcctgattt tcctggtgtg tgtaaaatat ttcctaggaa taaattaggc     3420

actttttaga agcaatgtta aatcattcag gttttatttt ctgccctgaa gcagaaattt     3480

aaaaaatgat attgggacct ggaaggttta atatggttca cagtgcctga attacacctg     3540

ctccgaaaac tagctttgta tttcttatga ctttgcataa gaactgttca tctttggatc     3600

ttgagcacct tacagataaa actttttatg gcatctcttt catggacagt gatattgatc     3660

ttttcacaat gtacgtagcc tctagaattt tgtacatatg tttgctcttt ttttgtacag     3720

actagttgtt gagaaaacag gggcgtttcc taatttggtc tttatcctgc gacaacactt     3780

tcagcagact agcctctcct tatctcacag atcacaagca cccctagata gtgtgattct     3840

gtcagatagc atttatgcaa aaatctatga agttaaaaga tcgtagaagc caaatgaaat     3900

gtacatatct actgactgat gacaagggaa tttcattagg aagaaggtaa agaaacatcg     3960

ttgagtagcc taccttgatt tctgtcaagt tcataaccag cttcatattt taaaggcttc     4020

aggtttgaaa ttaagtcaac tgcatgcagc tttgctgata aatgaataat tctctttgat     4080

gccatttatg agaaaagact tcaatatctg ttgcctgtca tatttaagaa aaattactgt     4140

ttctactctc tgtatctgat tttaaaagaa aaaactattc atacctggct tccaggtaat     4200

tgactttgaa ttcttacaag caaaggtcat tgtgtttttc ttgaatagac atctaataaa     4260

ttttgcttgg aagtatactt cagtttttct tcttgacatt tatctttata aaaattgtgt     4320

attttattcc aacttgttaa actaagagaa aatgca                               4356


<210> 3472
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 3472
ccggagcggg gatcacctca acttgactgt ggtcccccag ccctccaaga aatgcccata       60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa      120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt      180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt      240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca      300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc      360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc      420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc      480

tcctccatcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc      540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg      600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc      660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg      720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct      780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc      840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc      900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac      960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga     1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg     1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg     1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct     1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc     1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta     1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct     1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat     1440

ataattcccc tctgga                                                     1456


<210> 3473
<211> 2607
<212> DNA
<213> Homo sapiens

<400> 3473
gcctgaactg tttgtacctc tgggccatat tgcagaaccc tgcccttctt tgttgactga       60

ggaaagctcg ctccctgccc aggtttttca ttgttgatcg aaattaacac caggtggtga      120

atagagcccc tcctaaggtt gctcaggata aatcatttat taaataggtc tgcttatcag      180

gaggggcgtg aaggctccca aaaggaaatg ctggcacctg ggcccagaag ccagggcctc      240

taactcctgg ggttgatttc ttcagtgaag ttgcacccta caaagggaat atggccaaag      300

cggcactcaa ctgaaggctg atatcaggcg attagacagc catgcattct gcgtttgtct      360

ggaatggatt gtagagagat ggacttatat gaggactacc agtccccgtt tgattttgat      420

gcaggagtga acaaaagcta tctctacttg tctcctagtg gaaattcatc tccacccgga      480

tcacctactc ttcagaaatt tggtctgctg agaacagacc cagtccctga ggaaggagaa      540

gatgttgctg ccacgatcag tgccacagag accctctcgg aagaggagca ggaagagcta      600

agaagagaac ttgcaaaggt agaagaagaa atccagactc tgtctcaagt gttagcagca      660

aaagagaagc atctagcaga gatcaagcgg aaacttggaa tcaattctct acaggaacta      720

aaacagaaca ttgccaaagg gtggcaagac gtgacagcaa catctgctta caagaagaca      780

tctgaaacct tatcccaggc tggacagaag gcctcagctg ctttttcgtc tgttggctca      840

gtcatcacca aaaagctgga agatgtaaat atacgttcca ttcagcattc aattagcatg      900

cctgctatga gaaactcccc aacttttaaa tcatttgaag aaaaggtcga aaacttaaag      960

tctaaagtag ggggaaccaa gcctgctggt ggtgattttg gagaagtctt gaattcggct     1020

gcaaatgcta gtgccaccac cacggagcct cttccagaaa agacacagga gagcctgtga     1080

gattcctacc tttgttctgc tacccactgc cagatgctgc aagcgaggtc caagcacatc     1140

ttgtcaacat gcattgccat gaatttctac cagatgtgct tttatttagc tttacatatt     1200

cctttgacca aatagtttgt gggttaaaca aaatgaaaat atcttcacct ctattcttgg     1260

gaaacaccct ttagtgtaca tttatgttcc tttatttagg aaacaccatt ataaaaacac     1320

ttatagtaaa tggggacatt cactataatg atctaagaag ctacagattg tcatagttgt     1380

tttcctgctt tacaaaattg ctccagatct ggaatgccag tttgaccttt gtcttctata     1440

atatttcctt tttttcccct ctttgaatct ctgtatattt gattcttaac taaaattgtt     1500

ctcttaaata ttctgaatcc tggtaattaa aagtttgggt gtattttctt tacctccaag     1560

gaaagaacta ctagctacaa aaaatatttt ggaataagca ttgttttggt ataaggtaca     1620

tattttggtt gaagacacca gactgaagta aacagctgtg catccaattt attatagttt     1680

tgtaagtaac aatatgtaat caaacttcta ggtgacttga gagtggaacc tcctatatca     1740

ttatttagca ccgtttgtga cagtaaccat ttcagtgtat tgtttattat accacttata     1800

tcaacttatt tttcaccagg ttaaaatttt aatttctaca aaataacatt ctgaatcaag     1860

cacactgtat gttcagtagg ttgaactatg aacactgtca tcaatgttca gttcaaaagc     1920

ctgaaagttt agatctagaa gctggtaaaa atgacaatat caatcacatt aggggaacca     1980

ttgttgtctt cacttaatcc atttagcact atttaaaata agcacaccaa gttatatgac     2040

taatataact tgaaaatttt ttatactgag gggttggtga taactcttga ggatgtaatg     2100

cattaataaa aatcaactca tcattttcta cttgttttca atgtgttgga aactgtaaaa     2160

tgatactgta gaacctgtct cctactttga aaactgaatg tcagggctga gtgaatcaaa     2220

gtgtctagac atatttgcat agaggccaag gtattctatt ctaataactg cttactcaac     2280

actaccacct tttccttata ctgtatatga ttatggccta caatgttgta tttgttattt     2340

attaaattgt gattgtttta ttattgttta tgccaaatgt taactgccaa gcttggagtg     2400

acctaaagca ttttttaaaa gcatggctag atttacttca gtataaatta tcttatgaaa     2460

accaaatttt aaaagccaca ggtgttgatt gttataaaat aacatgctgc cattcttgat     2520

tgctagagtt tttgttagta ctttggatgc aattaaaact atgtgctatc acatgtgaaa     2580

agcttaataa attccatcta tcagtag                                         2607


<210> 3474
<211> 572
<212> DNA
<213> Homo sapiens

<400> 3474
ttttcggagg ctgccagcgt cccacaccag ccgcaggtga aaaccggcag aaagacatta       60

agagattttc ctgcagtcac tgctggcaga tgatagagcc aggatttgaa agcaggcagc      120

ctggctccag accctgtgct cttaactccc gttttgcatc aagaacagaa tcctatgaaa      180

ggcttgcaca gtgcttggta ctgagtaggc actccgtcag tattttagta gctattattc      240

caaaggacac tgtattctag gatagcagca tcaaggagca ttgtgtacat gcagaagtgc      300

acagtacctg gagtgaaact gcttgtgttc gatttctgat accattcata actggctgtg      360

tgatctcaaa taagaaaact gaagaaccag ctgggcgcgg tagctcacgc ctgtaatccc      420

agcactttgg gaggctgagg cgggtggatt acctgagaac ctctaaaatg cagacctcca      480

gctctagatc tgtgcacctg agtgaatggc agaagaatta cttcgcaatt acatctggca      540

tatgtaccgg accgaaggca gatgcatacc gt                                    572


<210> 3475
<211> 2792
<212> DNA
<213> Homo sapiens

<400> 3475
aggttggagc cgctgccgtc gccatgaccc gcggtaacca gcgtgagctc gcccgccaga       60

agaatatgaa aaagcagagc gactcggtta agggaaagcg ccgagatgac gggctttctg      120

ctgccgcccg caagcagagt gctattactt catcccggaa tttcctttac ccagcctatg      180

tctactttcc ctcctctgtc ccctccccac ccagaaagta cacacaaacc tattatgcag      240

ctgtgcccgc gggctggtgg gggagtggag gtggaccagc aacacagcct gcagcaggtg      300

gaaggtggcg gttcctgcac atactcggta cacagcccca gagccactga gcactggaca      360

gtcagagagg ccaaacagga ggcagcagat tgctgaggcc cccacatgga ggaggatgta      420

gaacaggcgg ctgcaagtgg atgcggtgag agagggccac ctagagtggc agcagctggc      480

acaaggagca ggcccacagc agcacacctg ggagtagagc agatgcaagg cagcgaggtg      540

gagacttgct gaggaaaggc atacgttaat gtatgtgtga ggttaaccca ggaggttgaa      600

ttccaaaatt tccccttccc ctttcttcct tttactcagg ttctgtttca agctgattcc      660

agccatttgg gattgccgcc cactgacaac ttagtagggc tttcattata agcaggcttg      720

agatatctga cctttctctc gacctaaaca cctggggctg gaaacatggc gggagagatt      780

tacagattat acctggggca acgaaccaga acgacattag aggagaaaag aggcctgtcg      840

tttttattgg cttctgcacg tcttcctccc cagcttcggc cactctcccc ttcgcaccct      900

ctcacctgac agaagggact tttcactagg acactgctgc ctccgctgtg ctgctgtgcc      960

aggcccaggg aggtgccggg gctggggccg gccttggcac ccaccatcct tgtcccaggg     1020

attaggctta ggtccaccag atggaaggca gatgagagca gcagttgctt ctgtcctcag     1080

cccattggac tgccactgtg ttggggctga gcacccggtc ccgggcagaa tggagacgtc     1140

cggaagagaa cactgacctc caggttgcgg taaatgcaaa tgccctgtga aggagctttg     1200

tccttagggc ctcaacactg cggccactca ggctgttctc tccagattag ggggcagttt     1260

gtctatctgg ccccctgtgg attagcattc tttattggtt taggattaga cgtcattcag     1320

gttgaacgga gttccctgag gtgggtgggt gcgtgtttat gtgttgaggg gactattcct     1380

agtttatgag gtggttaagg atatcggtgg ggtgggctgg agcggtgtcg ggttaggtct     1440

gagagaaggc ctcgcacaaa acactgtaca aacccgaaag gaagtctgag agacgaaccg     1500

ccttcctccc tgaagcttct agaactggag cagaaagaag gtgtggccca gggccagccc     1560

cgcctcctcc ccgggcggaa gctgtgtcag ttgccggaag tcggcgtgag gtggggctta     1620

tgcggcggcg tggtgaaata gatatggcga ccgaggggga tgtggagctg gagttggaga     1680

ctgagaccag tggaccagag cggcctccgg agaagccacg gaaacatgac agcggtgcgg     1740

cggacttgga gcgggtcacc gactatgcag aggagaagga gatccagagt tccaatctgg     1800

agacggccat gtctgtgatt ggagacagaa ggtcccggga gcagaaagcc aaacaggagc     1860

gggagaaaga actggcaaaa gtcactatca agaaggaaga tctggagcta ataatgactg     1920

agatggagat atctcgagca gcagcagaac gcagtttgcg ggaacacatg ggcaacgtgg     1980

tagaggcgct tattgcccta accaactgat gcgtgctttc tcaaatatac ctactggatt     2040

aatttatggc aataaaattt ttttttgtct ttttcagttt tatcatcttg ggtcaagtag     2100

agtgtatact atatcctatg ttgtggagaa tttatatgtt ggagactaac tgaatttaag     2160

tgacccatta aaatctagca cacctgtatg aaaaatcagt gtagaagaat acctcatgtg     2220

cagatgctag gtggcaggcc agtctcattc atctgactag ctctcaacag tattcaaggt     2280

acatctggag tctcagcaga gttactgtac tcaaatggca tgtgtctcca agacagctta     2340

tgaatatcta aaaggccagc tacctgccta ggagccacta tatatataga tagatgtagg     2400

ttatgaaccc agttcatagg ccaccttgag ttagaatttt ggtacctaca acatgcttga     2460

ttttgagtga ttaaaaaaaa ataatttggc tgggtgctgt ggctcacacc tctaatccca     2520

gcactttggg aggtcgaggc aggtagatca cgaggtcagg aattcaagac cagcctggcc     2580

aacatgtgaa accccgtctc cactgaaaat agaaaaatta gctgggcatg gtggtgggcg     2640

cctataatcc cagctattct ggaggctgag gcaggaatcg cttgaaattg gaaagcagag     2700

gttgcagtga gctgagatca cactactgta ctactgtact ccagcctggg ggaaagagtg     2760

aaactccatc tcaaaaaaaa aaaaaaaaaa aa                                   2792


<210> 3476
<211> 3198
<212> DNA
<213> Homo sapiens

<400> 3476
agtaacgcct tctccaagtg gatggcgggg tggacacgcg tcccggcgcc ccgggctccc       60

tgggatatgt agttcgcgac aggacgagcg gaaatactgc caggatttta ccacctctcg      120

cccatttatt tacttctcgg tcaccgcttt cgggggacag ataaacacca cagatgccca      180

tcaaaggggc gcacgggtct ggaggcgcag ctcaggtttt tgcgttggtc accctgccct      240

ccgcacgtgg agagggcagg cataaagcac cttgaaagga aggtgctgtc aatgctatcc      300

gacgacctgt cgccgggcac cgcagcatcc tcgctcgctc cgatgggacg agggacgccg      360

gccccagggt aacaggaggc gcctcgccgg ccgcgcgctg gatgctgtga tccaggtccg      420

gagccgggtt ccgccgcggc cgcagcgacc cgaccccacc cgacaggcca gaggcaatgc      480

aaagaaacaa gtttccaaga gaaaaacttc agataaaaag ggaagatatc agaaggaatg      540

tcctcagcat tctcctcttg aagatattaa acagcggaaa gtattagacc tcagacgatg      600

gtactgcata agccgaccac agtataagac ttcttgtggc atctcttcat taatttcttg      660

ttggaatttc ttatacagca caatgggagc tggaaacctt ccacctatta cccaagaaga      720

agctttacat attctgggct ttcaacctcc atttgaagat attaggtttg gtcctttcac      780

ggggaataca acacttatga ggtggtttag acaaattaat gaccacttcc atgtaaaagg      840

atgctcttat gttctatata agcctcatgg gaagaataaa acagcaggag aaactgcttc      900

aggggccctg tcaaagttaa cccgtggatt gaaagatgaa tcgctggctt atatctatca      960

ttgccaaaat cattattttt gtccaattgg cttcgaagca acccctgtta aagctaataa     1020

agcattcagc aggggacctc tctcaccaca ggaagttgaa tattggatct taattggaga     1080

atcaagtaga aaacatcctg ccattcactg taaaaaatgg gcagatattg ttactgatct     1140

aaacactcaa aatccagaat acctggatat ccggcactta gagaggggac tgcagtatag     1200

aaaaacaaag aagccaacat ttttttcttc tcaggttggg ggaaatttgc attgcatcat     1260

agcattccag agacttaact ggcaaagatt tggcctttgg aactttccat ttggaaccat     1320

tagacaagaa tcacaacctc caacacatgc ccagggaatt gccaaatctg agagtgaaga     1380

caatatttcc aagaagcagc atgggcgtct gggccggtct ttcagtgcta gtttccatca     1440

ggactcggca tggaaaaaga tgtctagtat ccatgagaga aggaacagtg gttaccaggg     1500

ttacagtgat tacgatggga atgattgact atgcttgcta ctgaacagct ggcattatat     1560

atgaaactgc tatatacagg actgtataaa gacagtagaa gattttagta agcctacatt     1620

aaataggagc agatcttgtg gtataaaaaa taaccttgta gttctccaga tactaagctt     1680

gtatatgatt atggtgggtg atttcagata tataagcaga taagcacaga ttattgtcct     1740

ttcaagttaa gagtatataa tctggacaga aaatttcaca aaattcaata aaattacaac     1800

tgttgtctaa ataagtgaaa cacaaattca cttaatagca tcaagatttg aaatacttaa     1860

gcatgaagtg acttttataa tgactcgatc cctagacatt tgttacagat agttttatgc     1920

ctaagaccaa gatgtaaagt accatctgcc cttaaaaaaa attggggctg tcaatttcta     1980

gttttcactc atggttaaca cgcatttaaa attatttcat gagtctagta gttctttgat     2040

ttatagcagg atcttgcttg cctcatttgt ttcctggtta tgttcttagg attctgacta     2100

agaggcaaaa gagaaaagac tcaagaaact gatcctggag atcgagacca tcctggctaa     2160

catggtgaaa ccccgtctct actaaacata caaaaaatta gccgggtgta gtggtgggca     2220

cctgtagtcc tagctactcg agaggctgag gcaggagaat ggcgtgaacc cgggaggtgg     2280

agcttgcagt gagcggagat cgcgccactg cactccagcc tgggcgacag ggcaagactc     2340

tgtctcaaaa aaaaaaaaaa aaaaaaagac ggatcctttt ttttggtgca aatgggtgac     2400

ttagtgcatt gattcagatt tttaaaattt cttgatgtgg tttgtaataa tcaaatattg     2460

acaagaacct taggtctcga aagactttta taagtctaga tgacgtttgc cttaggggta     2520

aagtaaaaga acaattggca ccttaagttt ctatacccaa ggttatctgt gaaatgagat     2580

ctcctgatat ttgattgctt tctcagtatg gagtcatatg ttgataacag tactgaagat     2640

gcataagaaa tgcccaagtc actcagagga caactaccca tattccagac tctgagctgt     2700

ttccttttta aaaatcatat agacaattag ctgtttgaag tgagtattaa atatttcaga     2760

agtgtgaatt tcatgtattt gagctcctct agttgctgtt ggtttttctt ctgctgccaa     2820

cctgtgactc acaaatgact aggatctctt gttctttaat tttagggtct tgttccagga     2880

ctcaaatcag taacttggtg attacaaggt gctgaatgtg ttggtaacca tatcgcaata     2940

cacctcaagg aaaaggttca gatttttatt tttaaaatat tttcattttt ttcttgaatt     3000

ttatatccgt ttgttcactc gtacatgcct agcctacaga aggggatata tattatgaaa     3060

tggtcatttt tctgaagaga atattttgct tgaaatgcaa aggactgaaa gagatttgta     3120

ggttgttgat tttgttactt catactggaa cttttaaaaa gatttcatca aataaagttt     3180

tgttttctac ttttaatt                                                   3198


<210> 3477
<211> 486
<212> DNA
<213> Homo sapiens

<400> 3477
ggacaacgcc ctggcgaggg cgaggtgggg tgtgcgccgc gcctgagagg cgggtccctg       60

cctcgccgca ggtgacgggc tcccctcccc aggtgtgtgg gcgcagccgg ccgccgccga      120

cctcttcggc cccctgagag gtgccctctc ctcccgagct ccctccccca cgaagagtcg      180

ggtgcagggc tgggccccgc ggtgacaggc gcggtgtcta cgaagaccgt gtggctggaa      240

gatcggcctt gctggtatga tttaagcttg gatgaaatga gagctttgac agttcagaga      300

gtgaagtttg ccatggacct gcctctgtta aaacgtgcag gtcaggatct ggcagagaaa      360

acaaagaatt ttgtcagccg aagccttgtc ataggagaag tcctctccat ggcggacatg      420

gccacaggag tgaagtgcgg aataatttat tggctatttg gtggtgctat caggaatctc      480

ggaagc                                                                 486


<210> 3478
<211> 3936
<212> DNA
<213> Homo sapiens

<400> 3478
acaccctcgc ggagagagcg gttcttgcag catcctgcgc agcccctgcc cagtttggtg       60

cagaggcgtg gggggcggga cgcgtctttg ccattctgat agcggggaaa gcggtgagaa      120

tcgaagtgag gagccgccag aggagagctg aggagaggag ggggaggtcg acgacctggg      180

ccctgggcct ctgaaggtcc atctccactg gtggctgtgg tggctttgga ttgttggaag      240

accatcacct tcagcaggtc tgcacttggg aacaatcatt ctcccccagc ccgagcgtgc      300

ctctgccctc tgtatcattg acagaggctg tatgtttgga aagagaactt tgtgactgca      360

gaactgacag ttgactctaa ttcttgctac caagtttttc cccgacccag tgaaagagtg      420

ttaagacttc gacctaggac acattgagaa ccaaggccaa gactggacag ggccatataa      480

ctgggcttca accatggctg ggactaagaa taagacaaga gcccaggcca aaactgaaaa      540

aaaggctgct atacaagcta aagctggagc agagagggag gctactggtg ttgttaggcc      600

tgtagccaag accagggcca aagcaaaagc caagacaggg tctaagacag atgcagtagc      660

agagatgaag gcagtgtcta agaacaaggt tgttgctgag acgaaggaag gagctctgtc      720

agagcctaag actctgggca aagccatggg agatttcact cccaaggctg ggaatgagtc      780

caccagctcc acatgtaaaa atgaggctgg tactgatgcc tggttctggg ctggggaaga      840

ggccactatc aattcctggt tctggaatgg agaagaggct ggtaatagtt tcagcactaa      900

gaatgataaa cctgaaattg gtgcccaggt ctgtgctgag gagttggaac ctgcggctgg      960

ggccgattgc aaacctaggt caggggctga ggaggaggag gaagagaatg ttattgggaa     1020

ctggttttgg gaaggagatg atactagttt tgaccctaat cctaaacctg tgagcaggat     1080

agttaagcct cagcctgtgt atgaaattaa tgaaaaaaat aggcccaagg actggtctga     1140

ggtaactatc tggcccaatg cccctgctgt aactccagct gtgttaggat ttagatccca     1200

ggcaccatct gaggcaagcc ctccttcata tattgttctg gcctccgctg aagaaaatgc     1260

ctgttctttg cctgtggcaa cagcttgccg cccttctagg aacactcgct catgctcaca     1320

gcctatccct gagtgtcgtt ttgattctga cccctgcatc cagaccatag atgagattag     1380

acgtcaaatc aggatcaggg aggtaaatgg gattaagcca tttgcttgtc cttgcaaaat     1440

ggaatgctat atggattctg aggaatttga aaaacttgtt agcttactta agtcaactac     1500

tgatcctctt attcataaaa tagcacggat tgcaatgggt gtccataatg ttcacccatt     1560

tgcccaagag tttattaacg aagtaggtgt agtgacactt attgaaagct tgctcagttt     1620

tccttcccct gaaatgagaa aaaagactgt aattactctg aatcctcctt ctggggatga     1680

aagacaacgc aaaattgaat tacatgttaa gcatatgtgt aaagaaacca tgtcatttcc     1740

tttgaactca ccgggacagc aatctggatt aaagatacta ggacaactga ctactgattt     1800

tgtccatcac tacattgttg ccaattactt ttcagagctt ttccatttgc tgtcctcagg     1860

aaattgcaaa accagaaatc ttgttttgaa actactttta aatatgtctg aaaatccaac     1920

tgcagccaga gacatgatca atatgaaggc attggcagca ttaaaactca tctttaacca     1980

gaaagaggca aaagccaatc ttgttagtgg tgtggccata tttattaaca taaaggagca     2040

tatcagaaaa ggctcaattg tagttgttga tcacttgagt tataatacac tcatggccat     2100

tttcagggaa gttaaagaga ttattgaaac aatgtaaaat gagccagaga tagaacattt     2160

taagccatct tcaaactcta gcaggctgta cattacagtg tacacattat acactgcatc     2220

tttaacacag agtcacctgt gacaggctct aggtttgagc tagactattt tgggggtatc     2280

aaatgaatat tataccttgg gctgaaaatg tttgattttt atcttgtcta gattggcata     2340

tttttaacat tttacttaag atagcaaacc agttcgtttt aagtaagcta acttgttcat     2400

tagtatctgt ggcttaaaat ggcaaaaaag aaaatatcct tgagtttgta atctagttac     2460

agaagtaagg catacacaca cacaaagata acagtaccta gagagagagt gtgtgtgagt     2520

gtgcgtgtct ctgtgtgtgc acgtgcacgc tcatggccaa atgtgcgcac tctacataaa     2580

ggaggcagga gttcctatag gctatttaat gtaagagaaa ctatttttct cctgttccag     2640

ctgtatcaga tactcgttcc gcaacacaga aatgactcag aatctcagac aaaatgtatt     2700

atttgttcaa ttttaatttt gctactacat tcataactct taaattgtta ggctgtttca     2760

tttacatcaa agttatctca caaaagagaa ggcaggaaac gttttgtgag tgcctattct     2820

atgtcaaaca ctgtgttggc accatatttt acaagttttt ttcctcttct cacagtgatc     2880

ttgtgagtta gttacttata tttttattag aactcattat tctgggtacc ctccaatgag     2940

aattagagag gttaaatacc ttttcctaga ttcccacagc aggaaggtgg catagctgtt     3000

ttgtctgaca ccagaaccca tctcaccaca ctgctttaca gtcttcctga aggacatttt     3060

gaggtggggg ggccttcaaa gctcagagac tggtttgaat ggtttaattt tgcaatggat     3120

catgtccatg ccaggtgtta caattcttaa cttcctccaa attcgtgtgt ccattagaca     3180

tttggctaca tctggctgga ggtcaggaga aaattctgag gtaaatagat ggattttatc     3240

tggcagtgtc gaaaatagta ggagcctaaa actttgttca atgagtaaga tgtagatttg     3300

gagtcatcag caggggaaac ttgttagatg tcctttgtat ctttttctat ccatttgtat     3360

tttttctttc ccaaagagct gaaatcattt tataccctga atttaaaagg taattgcttt     3420

tttcctcctt gcgaaatcat accttaattt tttttttttt tttttttacc atttatgatt     3480

tattctccta tgtgtcatat gaaaggccaa ggggctttat cttttactag taggcaagcc     3540

tgggcatttc tgcatttgtg ccagctaaca ctacaaaata gacttaatta gagaaattta     3600

gacccagaat tgcagcttca acaacacaaa acaggaaagc tagaagaggt tgctgtgtca     3660

acctacaaga tagtgattct tggaagttgg tatggaccag aaagcattcc caggacattt     3720

aggctatggc tgagttctct aagactcagg gtgggaatta taatccctgg tctaagctga     3780

tatgaaagtt tctatgtgtg aaaatatgga gttatatgct ttgagatttt ctgccagtta     3840

aactaaaaca agatcatact gtaaatgttt gtaacttgct tccccccact gtatactgta     3900

aacatctttg catgtcaata aatatgcctc tacaac                               3936


<210> 3479
<211> 489
<212> DNA
<213> Homo sapiens

<400> 3479
atgtcctaca actgttgctc tagaaacttc tcctcctgct cccacggggg ttacttgcac       60

tacccaggct cctcctgtgg ctcttcctac cccagcaacc tggtctacag cactgacctc      120

tgctctccca gcacctgcca gctgggttcc tctctctata ggggctgtca ggagacctgc      180

tggaggccca acagctgtca gacattctgc tactacccca ggactcacat gctctgcaat      240

tcttgcctga ctatgcatgt tgggtctcgg ggttttggat ccaatagctg ctgctccctg      300

agctgtggat ccaggagctg ctcctcactg ggctgtggat ccaatggctt cagatatctg      360

aattatagaa tccatacctc cccttcccag agttatagat ccagattctg ccatccaatc      420

tattttccac ctagaaggtg gttccattca tcttgttatc agccattctg tagatctggt      480

ttctactga                                                              489


<210> 3480
<211> 508
<212> DNA
<213> Homo sapiens

<400> 3480
tatgttttac agtctccatg ttcatctcct tttatgactt taaaaatata cctcaagata       60

gtagatgtga tggtcaatta tttataaatg gcaggaataa taaaaataat tctatttccc      120

tgtattttca aggtggcctt agacatgcat ctgccagcat tgggggttca gaagcctata      180

ggcacatgaa atttgaagga ggtgttcaca gagtacaaag agtgccaaag acagaaaagc      240

aaggccgcgt ccatactagc accatgactg tagcaatatt accccagcct actgagatta      300

atctggtgat taatccgaaa gatttgagaa ttgacactaa gcgagccagt ggagctgggg      360

ggcagcatgt aaataccacg gacagtgctg tccggatagt tcatcttcca acaggtgttg      420

tttctgaatg tcaacaagag agatctcagc tgaaaaataa agagctggct atgacaaagt      480

tacgtgcaaa actgtacagc atgcatct                                         508


<210> 3481
<211> 2166
<212> DNA
<213> Homo sapiens

<400> 3481
atggaggaag agctgaagtg tcccgtgtgc ggctctctgt ttcgggagcc tatcatcctg       60

ccctgttccc acaatgtctg cctgccttgc gctcgcacca tcgcggtgca gaccccggac      120

ggcgggagtg cagctggcgg cctcggcggc ggtgcgggag gtggcggaga ccacgcggac      180

aagctcagct tgtacagcga gacagacagc ggctacgggt cctacacccc gagcctcaag      240

tcccccaacg gggttcgcgt gctgcccatg gtgcccgcac cacccggctc ctcggctgcg      300

gcggctcggg gtgccgcctg ctcctcgctg tcctcgtctt cgagctccat cacgtgcccg      360

cagtgccacc gcagcgcatc cctggaccac cgcggcctgc gcggcttcca gcgcaaccgg      420

ctgctcgagg ccatcgtgca gcggtaccag cagggccgcg gggccgtgcc ggggacgtct      480

gcagccgcgg cggtggccat ctgccagctg tgcgaccgca ccccgccaga gccagcagcc      540

acgctctgcg agcagtgcga cgtcctctac tgctctgcct gccagctcaa gtgccatcca      600

tcccggggac ccttcgccaa gcatcgcctg ggcgccccca gcggaggcgg cggctgcaag      660

agcccgggag gcgcgggggc gggggcgact gggggcagca cggcccgcaa gttccccacg      720

tgtcccgagc atgaaatgga gaactacagc atgtactgcg tgagctgtcg aaccccggtg      780

tgttatctgt gcctggagga gggccggcac gccaagcacg aggtgaagcc gctgggggcc      840

atgtggaagc agcacaaggc acaactatct caggccttaa atggagtttc agataaggca      900

aaggaagcaa aggagtttct ggttcagcta aagaacatat tgcagcagat ccaggaaaac      960

ggactggact acgaagcctg cctcgttgct cagtgtgatg cccttgtgga tgctttaact     1020

cgtcagaaag ccaagctgct caccaaggtg actaaagaga gggaacacaa gttgaagatg     1080

gtttgggacc agatcaatca ctgcacattg aagctgcgtc agtccaccgg actgatggag     1140

tactgcctgg aggtgatcaa ggagaacgac ccctccgggt tcttacagat ctcagatgct     1200

ctgatcaagc gcgtccaggt gtctcaggag cagtgggtca aaggcgccct ggagccgaaa     1260

gtgtctgcgg agtttgatct gactttggac agcgagccgc tgctgcaggc catccaccag     1320

ctggacttca ttcagatgaa atgtagggtg ccacccgtcc ccctactgca gctggagaaa     1380

tgctgcaccc gtaacaacag cgtcacgctg gcctggagga tgccaccctt cacccacagc     1440

cccgtggacg gctacatcct ggagctggac gacggtgccg ggggacagtt ccgggaagtg     1500

tacgtcggta aggagacttt gtgtaccatc gacggtcttc acttcaacag cacctacaac     1560

gcccgagtca aagctttcaa ctcttctggt gtcgggcctt acagtaaaac tgtcgtcctg     1620

cagacatccg atgtggcctg gttcacattt gaccccaact ctgggcatcg ggacatcatt     1680

ttatccaatg acaaccagac agccacctgc agcagctatg acgaccgggt ggtgctgggc     1740

acagctgcgt tctccaaggg cgtgcactac tgggagctgc acgtggaccg gtacgacaac     1800

cacccagacc ccgccttcgg ggtggccagg gccagcgtgg tcaaggacat gatgctgggc     1860

aaggatgaca aggcctgggc catgtatgtg gacaacaacc gcagctggtt catgcactgc     1920

aactcccaca ccaacaggac ggaaggtggc gtgtgcaagg gggccaccgt gggcgtgctg     1980

ctggacctga ataagcacac tctcaccttc ttcatcaacg ggcagcagca gggccccaca     2040

gccttcagcc acgtggacgg ggtcttcatg ccagccctca gcctcaaccg caacgtgcag     2100

gtcaccctgc acacaggatt ggaagtgccg actaacctgg ggcggccaaa gctgtcaggc     2160

aattag                                                                2166


<210> 3482
<211> 2382
<212> DNA
<213> Homo sapiens

<400> 3482
ttcgcggtgc caccgccccg cccacgcctc ctcgccggcc tccgagtgcg tcacgtgacg       60

ggtcggtggc gctggcggtt gctgtcagct gattcccggg gttggtggca gcggcggtag      120

cagcaatgga ctttctcctg gggaacccgt tcagctctcc agtgggacag cgcatcgaga      180

aagccacaga tggctccctg cagagcgagg actgggccct caacatggag atctgcgaca      240

tcatcaacga gacggaggaa ggtcccaaag atgccctccg agcagtaaag aagagaatcg      300

tggggaataa gaacttccac gaggtgatgc tggctctcac agtcttagaa acctgtgtca      360

agaactgcgg gcaccgcttc cacgtgctgg tggccagcca ggacttcgtg gagagtgtgc      420

tggtgaggac catcctgccc aagaacaacc cacccaccat cgtgcatgac aaagtgctca      480

acctcatcca gtcctgggct gacgcgttcc gcagctcgcc cgatctgaca ggtgtggtca      540

ccatctatga ggacctgcgg aggaaaggcc tggagttccc catgactgac ctggacatgc      600

tgtcacccat ccacacaccc cagaggaccg tgttcaactc agagacacaa tcaggacagg      660

attctgtggg cactgactcc agccagcaag aggactctgg ccagcatgct gcccctctgc      720

ccgccccgcc catactctcc ggtgacacgc ccatagcacc aaccccggaa cagattggga      780

agctgcgcag tgagctggag atggtgagtg ggaacgtgag ggtgatgtcg gagatgctga      840

cggagctggt gcccacccag gccgagcccg cagacctgga gctgctgcag gagctcaacc      900

gcacgtgccg agccatgcag cagcgggtcc tggagctcat ccctcagatc gccaatgagc      960

agctgacaga ggagctgctc atcgtcaatg acaatctcaa caatgtgttc ctgcgccatg     1020

aacggtttga acggttccga acaggccaga ccaccaaggc cccaagtgag gccgagccgg     1080

cagctgacct gatcgacatg ggccctgacc cagcagccac cggcaacctc tcatcccagc     1140

tggcaggaat gaacctgggc tccagcagtg tgagagctgg cctgcagtct ctggaggcct     1200

ctggtcgact ggaagatgag tttgacatgt ttgcgctgac acggggcagc tcactggctg     1260

accaacggaa agaggtaaaa tacgaagccc cccaagcaac agacggcctg gctggagccc     1320

tggacgcccg gcagcagagc actggcgcga tcccagtcac ccaggcctgc ctcatggagg     1380

acatcgagca gtggctgtcc actgacgtgg gtaatgatgc ggaagagcct aagggggtca     1440

ccagcgaaga atttgacaaa ttcctggaag aacgggccaa agccgcggac cgattgccca     1500

acctctccag cccctcagct gaggggcccc cgggtccccc atctggccca gcgccccgga     1560

agaagaccca ggagaaagat gatgacatgc tgtttgcctt atgagtgtgg ggtctggcac     1620

cctgcagccc aggtccccac tgctctcaca cccttaggct gggacctccc tccctcctct     1680

ggtgttaagg ctgctttggg ggtggcttgt tacccccttt tcctcctctt tgaagacgga     1740

gctgccccag ctgtggctgg gggtgtggag gcagtgggat gaactggggg acaggtctgc     1800

gctgcagtgg gatctggctg ctctgcctcc tttcccaccc cagctgacca tgagactttg     1860

ctgagaagtg gaggccccag gacaggctgg ctggctggct ggctgcttga cccagtgtga     1920

ctctccttca ctgagtgata ccctgctccg ggcccatgcc ccaaggagcc cttcagagcc     1980

cacactgcca gtcgaggcct ggctggaggc tggccacagt ggaaattctg ccgagcctct     2040

tgtcccttcc ctgctctgct gcatggggcc ccatggcttt ggctggccac tgagggtagg     2100

gtgtggaggt gtggaggccc cctgaggagc tgcggcggcc caggtacgaa gctgcaactc     2160

tgcgcgcagt gggcgagatc tcatcagccc caggctgcag gtgaggcttc aggggatgct     2220

ggggccccac tgcccctccg ctgccttgcc ctccatcctt cctctgttcc ttctggccgg     2280

gcaccacagc actggggctc acctcttggt tgatcctctt gtactgggag aggtgccttt     2340

tgtatcccca attaaaggta gaaaaccacc ctgctagcag ca                        2382


<210> 3483
<211> 1041
<212> DNA
<213> Homo sapiens

<400> 3483
ggccgggatt cgcggcccgg agctcgggac cggagtcagg aatggagaga agggtaatgg       60

ttttacctct tattgtggaa acctgttgag atcacagaga atatactgac ggcataaaag      120

ggcagaacca tagcagggtg cggttgcttc attccagcct cgcagtcacc tctgtgccct      180

gctggttgtc ttcccagcgc tgctgtagtt gccttccatg gatctatagg agagcaagtc      240

ctccaggaga agaagtcctc accagtgaac ggagacctct ctgaactaag gataccatgg      300

ccacgtcagc cccactacgg agcctggaag aggaggtgac ctgctccatc tgtcttgatt      360

acctgcggga ccctgtgacc attgactgtg gccacgtctt ctgccgcagc tgcaccacag      420

acgtccgccc catctcaggg agccgccccg tctgcccact ctgcaagaag ccttttaaga      480

aggagaacat ccgacccgtg tggcaactgg ccagcctggt ggagaacatt gagcggctga      540

aggtggacaa gggcaggcag ccgggagagg tgacccggga gcagcaggat gcaaagttgt      600

gcgagcgaca ccgagagaag ctgcactact actgtgagga cgacgggaag ctgctgtgcg      660

tgatgtgccg ggagtcccgg gagcacaggc cccacacggc cgtcctcatg gagaaggccg      720

cccagcccca cagggaaaaa atcctgaacc acctgagtac cctaaggagg gacagagaca      780

aaattcaggg cttccaggca aagggagaag ctgatatcct ggccgcgctg aagaagctcc      840

aggaccagag gcagtacatt gtggctgagt ttgagcaggg tcatcagttc ctgagggagc      900

gggaggaaca cctgctggaa cagctggcga agctggagca ggagctcacg gagggcaggg      960

agaagttcaa gagccggggc gtcggggagc ttgcccggct ggccctggtc atctccgaac     1020

tggagggcaa ggcgcagcag c                                               1041


<210> 3484
<211> 567
<212> DNA
<213> Homo sapiens

<400> 3484
aggtcgcgcc aggcagggcc cccttcgcgg cgggcccgcg cgggtccctt ccacagcaag       60

gccacgcggt ccccctagcc tctcccgagt cccagctgcg gcgtgggcgc gttcccatcg      120

ggactcgtgg acgcgtcctg ctcccagctg cctttcgtct agagaaaggc aaccagatgt      180

ttgaggaggg cttggtggac aaaggtgaca ttcatgctcc actatatgca aaactggcca      240

aaggagagga aatggaaaaa tatcttggct ctgacaattg gttcagatgc agtaaataaa      300

aggaaaatga acttaagaaa tgcttaatgg atgcctaaag cagcttgtga tcactggaag      360

atcaattctt ttatcatcca tactttagag gcagcaaaat cgaagctttc ttcaccagta      420

aaagggaatg cgaagtaaat cacaacaaaa ttccatttca ccttcatcac actagaatag      480

ccaaacttaa aagtctgaat tgggtaaaaa taagtgacta aagaagcaga cctgggaatc      540

acctaacatg tcgaggagga gatttga                                          567


<210> 3485
<211> 657
<212> DNA
<213> Homo sapiens

<400> 3485
tttgttaaaa atcagaaaac ctttgacaca cttttagata aatacaccta ctcctttgat       60

cctttgtgta tgtattacca cagggcttaa atatcttaag attttagtta atgtcatttt      120

catgaaagac agtcatttgg aagccaagag ctctatctat gttttgttca aatagccgag      180

taatctacta tcttggcagt aattacttct gctgcatttc taatgtgaat tgcatgtgag      240

agcttatgaa tacactcttt tcaagtgtat gtgggttttc aaggttgacg atgtgtcaca      300

ctgtgtaagg gaatcgcatg gagatgggca ttccgaactg ttaatgggga catgggactc      360

cagttgtctc tgatcacttg tgtggatttt cctggcgtag aacgacagaa gccgctagta      420

agtcgccaag acctacagca ggaattctgc accaaagggc ataaaatctt gttattttaa      480

tttgcatctg ggagaatgtc tgagcaagga gacctgaatc aggcaatagc agaggaagga      540

gggactgagc aggagacggc cactccagag aacggcattg ttaaatcaga aagtctggat      600

gaagaggaga aactggaact gcagaggcgg ctggaggctc agaatcaaga aagaaga         657


<210> 3486
<211> 3546
<212> DNA
<213> Homo sapiens

<400> 3486
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact     1560

catatcaacc caagtaccat gtggacttga tccctggctg aatcacctgg atgacttgga     1620

atagaaatga ctgctttaga agatgggatg gggccgggtg gtaagggata gaagagagga     1680

ctctcaatct actgatcaag tcctttcccc aatgcccagt ggatggccag ggtacctggg     1740

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1800

tagaaagggc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1860

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1920

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1980

agtgtggtgg ccactggtga cttgaaaata tagagaaaaa aaaaacctgc tctatatctg     2040

aaagagctct tgggaagaca gagaaacata aagaggaaat tacagcacag tgtggtgggt     2100

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     2160

ggaaggagag ggtgagtggg ggatggcttt ctgaaaaggg tggtctaaag gatgcctatg     2220

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     2280

ggatgacctg tgactctgga gcactgggtt gtctccattg tcattatggg cagatgtgtg     2340

ccatccccag ccgacgccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     2400

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     2460

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     2520

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2580

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaacttta     2640

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2700

ggaatagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2760

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gtgtaaacta     2820

caatgctctg tcatctccct actgggtctc ctgggaggag gggagccatc cagggtgcaa     2880

actcaaaggc agagggcaca gcgtgcttag gcccaagctt agaattcaat tgagaagttc     2940

tgttgttcat ccttacctca gcaggtagaa aagaggtgga gatcagaagc cagggattag     3000

agattgaatt gctttccctg ggagtgtgca gtatctcatt aaaatgttgt atattcaaaa     3060

aaatacagac acacacaagt gcctatataa tgataaaaca tatccaaagc acccaaacct     3120

gtgattccag aaaagtagat cctatttttg tttattttta ttggctttag ctgtgtcttt     3180

tgaaaggact attatcctct aaaatgtatg tgtatgaaga tcctggcttg cagctcggga     3240

gctttacaca ccttgtgtca ctttatcttg gtaacgagcc aagatcatgc aaccagttca     3300

tccatgtctg acccaagagc tcttaactgc tatgctgcac tgcctcattc agagatagat     3360

gcctgcatgg gtcctggcga ttattttaat gctggctaca cccccacagg tgacttggat     3420

tcagaaatac aatttatatt tcttcttttt aaattgtttt attttatttt tcttttaata     3480

gttatatgtc agtgagaaca atttatatgt cttacactga gaaataaaac tgctcataag     3540

tgaaaa                                                                3546


<210> 3487
<211> 469
<212> DNA
<213> Homo sapiens

<400> 3487
gtcaccagga gggtatgcat agggagggca agagctctgg gccactgcga agattcaaaa       60

gctccaaaaa cctactgtag acatcgaaga accaatatat acaatgggcc aacaatccag      120

tgtccgcagg ctgaagagga gcgtcccctg tgaatccaac gaggccaacg aggccaatga      180

ggccaacaag acgatgccgg agaccccaac tggggactca gacccgcaac ctgctcctaa      240

aaaaatgaaa acatctgagt cctcgaccat actagtggtt cgctacagga ggaacgtgaa      300

aagaacatct ccagaggaac tggtgaatga ccacgcccga gagaacagaa tcaaccccga      360

ccaaatggag gaggaggaat tcatagaaat aacgactgaa agacctaaaa agtagcaaga      420

agctacatcc ctcaaacttc ggcaatgaaa ataaagtttg agaagctga                  469


<210> 3488
<211> 3354
<212> DNA
<213> Homo sapiens

<400> 3488
gcggcggcct gaactcacct aacaccgcag cagcaaccgg gcccggccag gttcggcgtt       60

ccgtgagtga acgatttaga aatctggact ggccagtgac ctctgggctt gccattccag      120

cctggtataa cctctggctc catgggcagc tactggctcc tacagaccgg atgaagcaga      180

ctggagacac aagtggagaa aacctccagc tggcaaatcc tcagagtgta ggcctctggc      240

tgccagtcct gcccagcctg cctcatggag aggatgaatt ggctgagcag actggcctcc      300

cggggccctg ggcaccgtat acctcaaggg gccaatctcc aaaccccagt catggctgat      360

cccgagacct gcctcatggt cttcaagaat cactggtccc aggtggtgcg aatcctggag      420

cggcaaggcc ctcgggcagc tcctgggggt gcagacgatc tcagtgctgt gcgcaaccac      480

acttaccaga tgttgacact gctggcagag gaccgtgcag ttccctcggc ccccacaggc      540

cctgggcccc tgctggagtt tgctctgcac gaggatctgc tgacccgtgt gttgacatgg      600

cagctgcaat gggatgagct tggggatggg gtcgaggaac ggcgggctga gcaactgaaa      660

ctatttgaaa tgctagtgag cgaagctcgc cagccactgt tgcggcatgg tccagttcgt      720

gaggctctgc tcaccctgct ggatgcctgt ggccgccctg tgcccagtag cccagcactg      780

gatgaaggct tggtgctact tctcagccag ctgtgtgttt gtgtggccca ggagccttca      840

ttgctcgagt tcttcctgca gccacctcct gagcctggag ccgctccccg tcttcttctc      900

ttttctcgcc ttgtcccttt tgtgcatcga gagggcaccc tgggccagca ggcccgtgat      960

gccctacttc ttctcatggc tttgtcagct gggagcccca ctgtgggccg ctacatcgcg     1020

gatcactctt acttctgccc ggtgctggcc acagggctca gtgccctgta ctcatcactg     1080

cctcgaaaga ttgaggttcc aggggatgat tggcactgtc tgcgacggga agactggctg     1140

ggagtgccag cccttgcact cttcatgagt tccctggagt tctgcaatgc agtaattcag     1200

gtggctcacc ccctggtgca gaagcagttg gttgattata tccataatgg gttcctggtg     1260

cctgtcatgg gtcctgcctt gcacaagacc tctgtggagg agatgatcgc cagtaccgcc     1320

tatctggaac ttttcctacg gagtatctca gagcctgctt tgctccgtac cttcctgcga     1380

ttcctgttgt tgcaccggca tgacacccac accatcctcg acaccctcgt tgctcgtatt     1440

ggcagtaact cccggctctg catggtctct ctgagtctct tcaggaccct cctgaacctc     1500

agctgtgagg atgtcctgct gcagctggtt ctcaggtatc ttgttccatg taaccacgtt     1560

atgctgagcc agaagccggc tgttcgtgat gtggacctat atggacgagc agctgacaag     1620

tttctctccc taatcccacg ctgttgtcgg caccacgccc ccagcccacc tcgtccagag     1680

catgcctcat gggcacgagg tcctggaagc ccaagtgtgg actcctcttc tgtgacgaca     1740

gtaccccggc cctccacacc atctcgtctg gctctcttcc tgcggcagca gagcctgggt     1800

ggctctgagt ctccaggccc agccccttgc tcaccagggc tttctgcatc ccccgcctcc     1860

agccctggcc gacggcctac ccctgcagag gagcctggag agctggaaga caattacctg     1920

gagtatctgc gtgaggcacg tcgtggtgtg gaccgctgtg tccgagcctg ccgtacctgg     1980

tctgccccct atgatggcga gcggccctct cctgagccca gtccttttgg ctcccggact     2040

aagaaacgca gcctactgcc tgaggaggac aggaacaacg tgggggaagg ggaggaggaa     2100

gagctgggga ggagggggcg ggctgggggt gcaggggagg gccctggtca cctgccccct     2160

ccccagctca atggagtgcc aggatcatgg cctgaggggg ccaagaaggt tcgtctggtg     2220

ccaaaggagg gagctgggga actgctagag ggcatctccg agggcatggc aggactagag     2280

ggctttgggc aggagctccg ggagctagag gtggcattga gcaatggggg aactggctca     2340

gagtccccct tagaacctcc actgcccctt gaggaggagg aggcctacga gagcttcacc     2400

tgtccccctg agccccctgg ccccttcctc agcagccctt tgcggactct caaccagctg     2460

ccaagccagc ccttcactgg ccccttcatg gctgtgctct ttgccaaact cgagaacatg     2520

ctgcagaact ccgtctatgt caacttcctg ctgacggggc tggtggccca gctggcctgt     2580

cacccccagc ccctgctccg ctctttcctg ctcaacacca acatggtctt ccagcccagt     2640

gtcaagtccc tgctgcaggt gctgggctct gtgaagaata agattgagaa ctttgcggct     2700

tcccaggagg acttcccagc actgctgtcc aaagccaaga agtacctcat tgcccgtggc     2760

aagttggact gggctgaggg ccctgcagca ggacctgccc cacgccgttc tgatccccta     2820

gtgaagagcc ggaggccatc cttgggggag ttactcctgc ggcatgcaca cagtccaacc     2880

agggcccggc aggcggcaca attggtcctt cagcctgggc gagacggagc aggacttggc     2940

ctaagtgggg gctcccctgg ggcttcaact ccagttctac tcacccgggg cggggcccct     3000

gaacgccaag gtgaggctct tcgagtcaag aatgctgtct actgtgcagt cattttccct     3060

gaatttctca aggagttggc tgccatctcc caggctcatg ccgtcacctc gcctttcttg     3120

ttggagactt cagaggaagg atctggccct ctcatctcag gctgtgggcc cctcaatcct     3180

taactttctt ccatggacaa tcagggccat gggtggcccg ggctggggct agggcacagg     3240

ctccttttta tgtttggagg cagtggcaaa aggacttttt aatttatttc agatgaatgt     3300

tttatggaga acttgttgca atatgtataa aagggaaatc tctattctgt gctc           3354


<210> 3489
<211> 2179
<212> DNA
<213> Homo sapiens

<400> 3489
agctttccag ttctgcttta ggacccgccc cccagcacgc tcctcgacgc tgcgaggtcc       60

cgccccgcgt gctggccgcg gtaaaagtgg tagcagcgga ggcgagcgga gggtttcccg      120

cggcggattt ctgacagtca gacttgtcca caagaactca actggcaagg ctgcttttct      180

gtgctaaaac tggggagcta gtgggcacca tgaagatctt ctgcagtcgg gccaatccga      240

ccacggggtc tgtggagtgg ctggaggagg atgaacacta tgattaccac caggagattg      300

caaggtcatc ttatgcagat atgctacatg acaaagacag agttttcaag cctatggctg      360

atgctgctgt gaagattgtg gagaaaaatg gctttagtga taagattaag gttatcaaca      420

agcattccac cgaggtgact gtaggtccag agggtgacat gccatgccgt gccaacatcc      480

tggtcacaga gttgtttgac acagagctga tcggggaggg ggcgctgccc tcctatgagc      540

acgcacacag gcatctcgtg gaggaaaatt gtgaggccgt gccccacaga gccaccgtct      600

atgcacagct ggtggagtcc gggaggatgt ggtcgtggaa caagctattt cccatccacg      660

tgcagaccag cctcggagag caggtcatcg tccctcccgt tgacgtggag agctgccctg      720

gcgcaccctc tgtctgtgac attcagctga accaggtgtc accagccgac tttacagtcc      780

tcagcgatgt gctgcccatg ttcagcatag acttcagcaa gcaagtcagt agctcagcag      840

cctgccatag caggcggttt gaacctctga catctggccg agctcaggtg gttctctcgt      900

ggtgggacat tgaaatggac cctgagggga agatcaagtg caccatggcc cccttctggg      960

cacactcaga cccagaggag atgcagtggc gggaccactg gatgcagtgt gtgtacttcc     1020

tgccacaaga ggagcctgtg gtgcagggct cagcgctcta tctggtagcc caccacgatg     1080

actactgcgt atggtacagc ctgcagagga ccagccctga aaagaatgag agagtccgcc     1140

agatgcgccc cgtgtgtgac tgccaggctc acctgctctg gaaccggcct cggtttggag     1200

agatcaatga ccaggacaga actgatcgat acgtccaggc tctgaggacc gtgctgaagc     1260

cagacagcgt gtgcctgtgt gtcagcgatg gcagcctgct ctccgtgctg gcccatcacc     1320

tgggggtgga gcaggtgttt acagtcgaga gttcagcagc ttctcacaaa ctgttgagaa     1380

aaatcttcaa ggctaaccac ttggaagata aaattaacat catagagaaa cggccggaat     1440

tattaacaaa tgaggaccta cagggcagaa aggtctctct cctcctgggc gagccgttct     1500

tcactaccag cctgctgccg tggcacaacc tctacttctg gtacgtgcgg accgctgtgg     1560

accagcacct ggggccaggt gccatggtga tgccccaggc agcctcgctg cacgctgtgg     1620

ttgtggagtt cagggacctg tggcggatcc ggagcccctg tggtgactgc gaaggcttcg     1680

acgtgcacat catggacgac atgattaagc gtgccctgga cttcagggag agcagggaag     1740

ctgagcccca cccgctgtgg gagtacccat gccgcagcct ctccgagccc tggcagatcc     1800

tgacctttga cttccagcag ccggtgcccc tgcagcccct gtgtgccgag ggcaccgtgg     1860

agctcagaag gcccgggcag agccacgcag cggtgctatg gatggagtac cacctgaccc     1920

cggagtgcac gctcagcact ggcctcctgg agcctgcaga ccccgagggg ggctgctgct     1980

ggaaccccca ctgcaagcag gccgtctact tcttcagccc tgccccagat cccagagcac     2040

tgctgggtgg cccacggact gtcagctatg cagtggagtt tcaccccgac acaggcgaca     2100

tcatcatgga gttcaggcat gcagataccc cagactgacc actcttgagc aataaagtgg     2160

cctgagggct ggggttctg                                                  2179


<210> 3490
<211> 3049
<212> DNA
<213> Homo sapiens

<400> 3490
gagctgagag gaccagccat tttacttatg gaaaacagtg tggcatattc tgctgagctt       60

cgccctggaa gaagcctctt ttatacatct cttcagggaa gagagaagca atgggcatgt      120

tagtatacaa tgatcacagc cacgcaggcc tgcaagctgc cttttggaca ggctgttgac      180

tgccgttcca attagctgat tggagaatgt ggaatgcaga gtgataatgc tgcatatctg      240

ctatcaggca gcagcaaagg tttttgtctt gggaaggcaa gctttccctg caatattatc      300

tcagcagctc cctagctgct taccctgaaa acgagggatc caaacggagg gtgttgcact      360

ctgctaacgc tggtcctgtg cgtggctgtg gcatatgagc ggcaggtctg aaaaagcagg      420

tgtgtgctgg gacgggcact ggactggaac gcaggcggac gctctcgggt ttacctgctt      480

cctgttaaca gattgtgggc tcccagggca tatgtctgca cgctgaggcc gaggcggaga      540

aggggcttcc tgagcgtccc agtacactga cagagacact tggattggac ttaatcttaa      600

acctctggag ttcaagacct tttaaaaagg gctaaataaa caatctctac atgtaaaagg      660

ccactgactc ctacttcctc tgtatagagc aactgttgaa ctcagctgcc tgtaggaaaa      720

ctgaagactt taataacaaa ctctccaagg tgaaaatgaa cacagcggtg ggtgtgctcg      780

caaacgtgcc gccatgtctg ttacgctaac atctgtgaag agagtgcaaa gttctccaaa      840

cctattggct gcagggcgtg attctcagtc accagactca gcttggagat cttacaatga      900

tggcaatcag gagacactga acggagatgc tacatattcc tctcttgcag caaaaggttt      960

tagaagcgtt cgaccaaacc tacaagataa aagatcacca actcagagcc agataacagt     1020

gaatggaaac tcaggaggtg ccgtgagtcc catgagttac tatcagaggc cgttttcccc     1080

ctcggcatat tctctcccag cctcactcaa ctccagcatt gtcatgcagc acggcacatc     1140

cctcgattcc acagacacat atccccagca tgcgcagtct ctggatggca ccaccagcag     1200

ctctatcccc ctgtaccgat cctcagagga agagaagaga gtgacagtca tcaaagcccc     1260

gcattaccca gggatcgggc ccgtggatga atccggaatc cccacagcaa ttagaacgac     1320

agtcgaccgg cccaaggact ggtacaagac gatgtttaag caaattcaca tggtgcacaa     1380

gccgggtctg tacaacccac cctacagtgc tcagtcacac cctgctgcaa agacccaaac     1440

ctacagacct ctttccaaaa gccactccga caacagcccc aatgccttta aggatgcgtc     1500

ctccccagtg cctcccccac atgttccacc tccagtcccg ccgcttcgac caagagatcg     1560

gtcttcaaca gaaaagcatg actgggatcc tccagacaga aaagtggaca caagaaaatt     1620

tcggtctgag ccaaggagta tttttgaata tgaacctggc aagtcatcaa ttcttcagca     1680

tgaaagacca gcctccttgt atcagtcctc tatagacaga agcctggaaa gacccatgag     1740

ttctgcaagc atggccagtg acttcaggaa gcggaggaag agcgagcctg cagtgggtcc     1800

accacggggc ttgggagatc aaagtgcgag caggactagc ccaggccgag tggacctccc     1860

aggatcaagc accactctta caaagtcttt cactagctct tctccttctt ccccatcaag     1920

agcaaaagac cgtgagtccc ctagaagtta ctcatccact ttgactgaca tggggagaag     1980

tgcaccaagg gaaagaagag gaactccaga aaaagagaaa ttgcctgcaa aagctgttta     2040

tgattttaag gctcagacat ctaaggagtt gtcatttaag aaaggagata ctgtctacat     2100

cctcaggaaa attgatcaaa attggtatga gggagaacac cacgggagag tgggcatctt     2160

cccgatctca tacgtagaga aactcacacc tcctgagaaa gcacagcctg caagaccacc     2220

tccgccagcc cagcccggag aaatcggaga agctatagcc aaatacaact tcaacgcaga     2280

cacaaatgtg gagctgtcac tgagaaaggg agatagagtt attcttctta aaagagttga     2340

tcaaaactgg tatgaaggta aaatcccagg aaccaacaga caaggcatct tccctgtttc     2400

ctatgtggag gtcgtcaaga agaacacaaa aggtgctgag gactaccctg accctccaat     2460

accccacagc tattctagtg ataggattca cagcttgagc tcaaataagc cacagcgtcc     2520

tgtgtttact catgaaaata ttcaaggtgg gggggaaccg tttcaggctc tgtataacta     2580

tactcccagg aatgaagatg agctggagct cagagaaagt gatgtcattg atgtcatgga     2640

aaagtgtgat gacggctggt ttgtggggac ctcaagaaga accaaattct ttggtacttt     2700

ccccggaaac tacgtcaaga ggctgtgaat tgcgctccct ccttctgtag aggccgcctg     2760

ccagccatgc acctgcgtca acgcgcctga aacaccccgc gggcctcccg ttgtcatgcc     2820

ttacggtttc caatgcgccg tcaccatctc cacctgccac caaaccacca gcagagtagc     2880

cgccgctgct gtgagcctgg ggacgacatg gcaggctggt ccccctccgt gaaagtgtgg     2940

attcctactt cctgctctaa gctttgacac gtcaaaatgt gggatcagaa agaaaaaaat     3000

catgatattt aaaaatggtc aaatatttga ggcaaaaaaa aaaaaaaaa                 3049


<210> 3491
<211> 2372
<212> DNA
<213> Homo sapiens

<400> 3491
ggcaggcggc gggggcgggg cctggaggag cctacaccga ctctggagga agactggagc       60

ctttgcggcg gcgctgcccc tcccctggtc cccgcgagct cggagggccc ggctggtgct      120

gcgggggccc cgggaggttg aaaactaagc atggggaaga gctgcaaggt ggtcgtgtgt      180

ggccaggcgt ctgtgggcaa aacttcaatc ctggagcagc ttctgtatgg gaaccatgta      240

gtgggttcgg agatgatcga gacgcaggag gacatctacg tgggctccat tgagacagac      300

cggggggtgc gagagcagat agcagagagt cttttcagcg tgtggagctg ctcaagaagg      360

agattgacaa atccaaggac aagaaggagg tcaccatcgt ggtccttggc aacaagtgtg      420

acttacagga gcagcggcgt gtagacccag atgtggctca gcactgggcc aagtcagaga      480

aggtgaagct gtgggaggtg tcagtggcgg accggcgctc cctcctggag ccctttgtct      540

acttggccag caagatgacg caaccccaga gcaagtctgc cttccccctc agccggaaga      600

acaagggcag cggctccttg gatggctgaa gagctgccgt tcctctttca cgatcccagc      660

cccatttcag tgtctggggc tctggtagat gtgttgaggg caaagtagag gacaagctgt      720

ctttcccagt cagccaggga gctccccgcc aggccacgcc ccagccactt tgctccctct      780

cacctctggg aagtgcaaat actcttggtt gacatcccct tcctcagccc tcccagccta      840

ctccccatcc cagcttttag aggatctgct ccactgtctc ctggggcagt tgtgggtcac      900

tgtcccttcc agctgcccca gacaggaagc agagtcacca cgcagcagtg tcccttcttg      960

ggtctgagtt cctattatag gtaggggccc caccctctgg gcttcccatc agcgacacac     1020

acacacttat ggcaccagcc tggactccag aaaaagggtg tccaggtatt gtgtgtatgc     1080

atttagttgt gcacacacaa atatgctcct atactggcat taggcgtctc ctcatccctc     1140

accctgacct ttctcctgtc cttttcttgg ctggaagaag ttggcctcct gggagtgtag     1200

ttttctgttt taaatccccc acccctggct gggctcagtg gctcacccct gtaatcccag     1260

cactttggga ggccaaggcg ggtcgattac ttgaggtcag gagttcacga ccagcctggc     1320

caacattgtg aaaccccatc tctgccaaaa atacaaaagt tagccgggcg tagtggcaca     1380

tgcctgtaat cccagctacc cggggaggct gaggcaggag aattgcttga actcagaagg     1440

cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtcaa cagagcaaga     1500

ctccatctcg aagaaaaaaa aaaaaaattc cccaccccta ccaattgttt tacttcctct     1560

tcctgctcag ggagcagatg ggcctcactg gttgagatgg aatagaataa ctgggctatg     1620

agtcaccagc ccactttgtg acccagcaag acctttcccc tctctgggca tcagtttctc     1680

atctgtaaga tgaccagagt tgcttagatg atctcctaga tcctttccag ttctcttgat     1740

ttcgtaaagc caatggcttc tccctcttta aggtgctatg ccaaccagcc ctggaggctg     1800

ggatctgccg ctccctccag ccaccagggg gcaggagtgc actacctgct gtcagtcacc     1860

agagtggccg ctcagtgccc agcccgccag cctcgctctt ggaggctgct ctttatcctg     1920

cctgtggttt tcagctcaga gctggacttc tatttataag ttacctgtat ttatatttat     1980

atgcccgctc tcatggtgaa ggctggacaa ggtgctcctc tggcccctcc ttcttacctc     2040

agatgcctga acagaacaag gcaaacccgt agcagcctct caggagctga caggtcctct     2100

ttcggggctc aggagggtgg gcacacaccc agcggcctgc agagtaagct tattacccac     2160

aactgtgccc gctttgtgct tctaaggtgc acacctagcc taggtgagac actgcagcca     2220

ggcaaccacc gacacacgcc ccttctcaaa gccagaggtg agtggggcag gtgcccgggg     2280

ctgggtgagt ggaattagga cacacacagg cttgggcttc aagttcattt attgatgcat     2340

tggttggaca caataaaacc acaattgtta tc                                   2372


<210> 3492
<211> 1047
<212> DNA
<213> Homo sapiens

<400> 3492
gaccgtgacg tagaaggtgg agaccgcttc accctgatca gggagtatcg gctgcgggtg       60

cgcaaggcgt ccaggagtga cctggggctg tggagagcga cccgtggcct tgtgtttcag      120

aaaaaggacc agtgatgtct aagactcatg atcatcaatt ggaatcaagt ctcagtcctg      180

tggaagtgtt tgctaaaaca tctgcctccc tggagatgaa tcaaggcgtt tcagaggaaa      240

gaattcacct tggctctagc cctaaaaaag ggggaaattg tgatctcagc caccaggaaa      300

gacttcagtc gaagtccctt catttgtctc ctcaagaaca atctgccagt tatcaagaca      360

ggaggcaatc ctggcggcga gcaagtatga aagaaacgaa ccggcggaag tcgctgcatc      420

ccattcacca gggcatcaca gagctcagcc ggtctatcag tgtcgattta gcagaaagca      480

aacggcttgg ctgtctcctg ctttccagtt tccagttctc tattcagaaa cttgaacctt      540

tcctaaggga cactaagggc ttcagtcttg aaagttttag agccaaagca tcttctcttt      600

ctgaagaatt gaaacatttt gcagacggac tggaaactga tggaactcta caaaaatgtt      660

ttgaagattc aaatggaaaa gcatcagatt tttctttgga agcatctgtg gctgagatga      720

aggaatacat aacaaagttt tctttagaac gtcagacttg ggatcagctc ttgcttcact      780

accagcagga ggctaaagag atattgtcca gaggatcaac tgaggccaaa attactgagg      840

tcaaagtgga acctatgaca tatcttgggt cttctcagaa tgaagttctt aatacaaaac      900

ctgactacca gaaaatatta cagaaccaga gcaaagtctt tgactgtatg gagttggtga      960

tggatgaact gcaaggatca gtgaaacagc tgcaggcctt tatggatgaa agtacccagt     1020

gcttccagaa ggtgtcagta cagctcg                                         1047


<210> 3493
<211> 2853
<212> DNA
<213> Homo sapiens

<400> 3493
cctccctcca gtctccggat ctccctcggt ccctctctcc tcctcttcct ctctctggac       60

gcccggctcc tccgcacccc ctcccccggg ggtcccgcgg ccttgctccc taccctcacc      120

tcaagacgac catggccacc atcccagact ggaagctaca gctgctagcc cggcgccggc      180

aggaggaggc gtccgttcga ggccgagaga aagcagaacg ggagcgcctg tcccagatgc      240

cagcctggaa acgagggctc ctggagcgcc gccgggccaa gcttgggctg tcccctgggg      300

agcctagccc tgtgctaggg actgtagagg ctggacctcc agacccggat gagtctgcgg      360

tccttctgga ggccatcggg ccagtgcacc agaaccgatt catccggcag gagcggcagc      420

agcagcagca gcaacaacaa cggagtgaag agctgctagc agagagaaag cctgggcctc      480

tggaggcccg ggagcggaga cccagccctg gggagatgcg ggatcagagc cccaagggaa      540

gagagtcaag agaagagaga ctaagtccga gggagaccag agagaggagg ctggggatag      600

ggggagccca agagttgagc ctgaggcctc tggaggctcg ggactggagg caaagcccag      660

gagaggtggg agacaggagc tcccgactgt cagaggcatg gaaatggagg ctgagtcctg      720

gagaaactcc agagcggagt ctgagactag cagagtctcg agagcaaagc cccaggagaa      780

aagaggtgga aagtagactg agcccagggg aatctgccta ccagaagttg ggcctgacag      840

aggcccataa atggagacct gactccagag agtctcagga acagagtttg gtacaactgg      900

aggcaacaga gtggaggctg aggtcaggag aagaaagaca agactactcg gaagaatgtg      960

ggagaaaaga agagtggcca gttccagggg tagctccaaa agagactgca gagctgtccg     1020

agaccctgac aagggaggcc caaggcaaca gttccgcagg agtggaggca gcagagcaga     1080

ggcctgtgga agatggcgag aggggcatga agccaacaga agggtggaaa tggaccctga     1140

actccgggaa ggctcgagaa tggacaccca gggacataga ggctcaaact cagaaaccag     1200

aacctccaga gtcagcagag aagcttctgg aatctcccgg tgtggaggct ggagaagggg     1260

aggctgagaa ggaggaggcg ggggctcagg gcaggcctct gagagccctg cagaactgct     1320

gctctgtgcc ctcccccctc ccaccagagg acgctgggac tggaggcctg agacagcagg     1380

aagaggaagc agtggagctc cagcccccac caccagcccc tctgtctccc ccacccccag     1440

ccccaactgc cccccaacct cctggggatc ccctcatgag ccgcctgttc tatggggtga     1500

aggcagggcc aggggtgggg gccccccgcc gcagtggaca caccttcacc gtcaaccccc     1560

ggcggtctgt gccccctgcg accccagcca ccccaacctc tccagccaca gttgatgctg     1620

cagtcccggg ggctgggaag aagcggtacc caactgccga ggagatcttg gttctggggg     1680

gctacctccg tctcagccgc agctgccttg ccaaggggtc ccccgaaaga caccacaaac     1740

agcttaagat ctccttcagc gagacagccc tggagaccac gtaccaatac ccctccgaga     1800

gttcggtact ggaggagctg ggcccggagc ctgaggtccc cagtgccccc aaccctccag     1860

cagcccaacc cgacgacgaa gaggatgagg aagagctgct gctgctgcag ccagagctcc     1920

agggcgggct gcgcaccaag gccctgattg tggatgagtc ctgccggcgg tgaccatctt     1980

ccaacatagg gatatacctc cctccttctt ataactgaag atcctggagc ccggaagatt     2040

cagggcagac agaccctgat aatgagcctg gcagggaagg gcaaccaaca tcttgtaact     2100

tgctttcccc accctgtttc tgggggcaga gccaattgcc caatttctac cctaatccaa     2160

agtccctggt gtgggtgggg ttaaacgtgc tggtgcatcc taggtcatcc aagagtgagc     2220

gccaagtcct gagaaggggc acagaactcc ctggagggtg gagatggagc acctgccccc     2280

catggcaggg tacactctcc ccacagcctt cctccccacc atcccgtggg gactctcggg     2340

atttaagcac tcgtctctct gggaggccca gaccccactc catttatagg cacatctcct     2400

tcatttccta ggtcactgcc cctttgttta cagctcctgc ctcctccctt gaccacagcc     2460

tggtttacaa attccatcag ctcccagccc cacctgccaa agtcccaggt ttacaagcca     2520

cgcttacttg ctgtgtctgc gtggaattct ctcctctgtc ccctccagtc tcctcattgg     2580

agtgacctga aggtgtggct tcctccactt tttctcagta ttactttgcc ttagttttcc     2640

ccaagaggga aggctggaac tcttaactct gtaccccttg atagttattt aattctgttt     2700

ctcctagtgg ttcacaattg aactgaattg agatggtgtc gggtggctaa ggagacacct     2760

cacctctcct tccccattgt gccgccttta tcaattgcct gttttgtttt gtttgttttt     2820

taactttcca taataaaatg gagttctctt caa                                  2853


<210> 3494
<211> 3050
<212> DNA
<213> Homo sapiens

<400> 3494
gtgcgccgtg gcgccgcctg cgaccggcag ctcgttcgcc gcactttgga ggcttcggct       60

gcccctccga cccacgtagg gcccggaccc gggcctcctt gtgaacagcg tgccggcttc      120

gccccacggg ttcaccggct ggctgggctt caagcgccga ggccgccgca gtgaccccgc      180

ccccgggccg aggatgtgag gcgggccggg cgtccccaca ccgggcccgg gcgccgggag      240

tgggcgtctg ggcagcgcca ggcgatggcc ctgctgctgg tgctcctcgc ctcttggggc      300

ctggggcagt gagggggccg gcgggcgtgg gccgagtggc cgcgggcgcc atggaggggg      360

tgctgtacaa gtggaccaac tatctgagcg gttggcagcc tcgatggttc cttctctgtg      420

ggggaatatt gtcctattat gattctcctg aagatgcctg gaaaggttgc aaagggagca      480

tacaaatggc agtctgtgaa attcaagttc attctgtaga taatacacgc atggacctga      540

taatccctgg ggaacagtat ttctacctga aggccagaag tgtggctgaa agacagcggt      600

ggctggtggc cctgggatca gccaaggctt gcctgactga cagtaggacc cagaaggaga      660

aagagtttgc tgaaaacact gaaaacttga aaaccaaaat gtcagaacta agactctact      720

gtgacctcct tgttcagcaa gtagataaaa caaaagaagt gaccacaact ggtgtgtcca      780

attctgagga gggaattgat gtgggaactt tgctgaaatc aacctgtaat acttttctga      840

agaccttgga agaatgcatg cagatcgcaa atgcagcctt cacctctgag ctgctctacc      900

gcactccacc aggatcacct cagctggcca tgctcaagtc cagcaagatg aaacatccta      960

ttataccaat tcataattca ttggaaaggc aaatggagtt gagcacttgt gaaaatggat     1020

ctttaaatat ggaaataaat ggtgaggaag aaatcctaat gaaaaataag aattccttat     1080

atttgaaatc tgcagagata gactgcagca tatcaagtga ggaaaataca gatgataata     1140

taacagtcca aggtgaaata aggaaggaag atggaatgga aaacctgaaa aatcatgaca     1200

ataacttgac tcagtctgga tcagactcaa gttgctctcc ggaatgcctc tgggaggaag     1260

gcaaagaagt tatcccaact ttctttagta ccatgaacac aagctttagt gacattgaac     1320

ttctggaaga cagtggcatt cccacagaag cattcttggc atcatgttat gctgtggttc     1380

cagtattaga caaacttggc cctacagtgt ttgctcctgt taagatggat cttgttggaa     1440

atattaagaa agtaaatcag aagtatataa ccaacaaaga agagtttacc actctccaga     1500

agatagtgct gcacgaagtg gaggcggatg tagcccaggt taggaactca gcgactgaag     1560

ccctcttgtg gctgaagaga ggtctcaaat ttttgaaggg atttttgaca gaagtgaaaa     1620

atggggagaa ggatatccag acagccctaa ataatgcata tggtaaaaca ttgcggcaac     1680

accatggctg ggtagttcga ggggtttttg cgttagcttt aagggcagct ccatcctatg     1740

aagattttgt ggccgcgtta accgtaaagg aaggtgacca ccagaaagaa gctttcagta     1800

ttgggatgca gagggacctc agcctttacc tccctgccat ggagaagcag ctggccatac     1860

tggacacttt atatgaggtc cacgggctgg aatctgatga ggtggtatga tggctgctgg     1920

gcagcacctc ctaacttcag ggaataagtg ctaaagtgtt ttgttgccct acttaatttc     1980

cagcaacagc ctcaaccctc tccaacccct tcacctgggg ggatggacag gaggtggcaa     2040

aacccagtgc ttttataatt tttaaaatgc atatgtgttt tgtttaaaga tcaaggtgct     2100

atatatttca gttcagcagg cctactggaa accaaatgat aagctgctgt agacttgaac     2160

agcaagttat aagagcagat ttaacaaaca aatttgctgt tattgtgtat tgtattgttt     2220

ttatatttta gtctaatggg ccacccaaac ccaagctgaa aatcagcaaa ttccatatta     2280

agtaccataa ttcatagcca gtgtttcagc caacttagac tagacatttg gaggtagtat     2340

aagctgcttt gttgaagctg tgtagagttt gctgttccta gatgttcttc agtggaccct     2400

cttcactgca actctgtcag tgataagggc ctgtgtagta aagatgttca gggcattcac     2460

atgaccatgc aattgtggga ggcgaagaag acgtggacag gagtcccatc cttgctgaca     2520

ggcatgaaac cgttgctctg agaagattaa tggtgtgccc tagccccaag ttggagggga     2580

gaatatgaga gaggtgggac aggtcatttg agatgacacc tcccaactgc ctaccattta     2640

ccagcatgtt ccccatgcat tatctcaatt ggacatcaca agtaatgata cccagaggga     2700

ttattactcc acttcaaaag caaggtttag aagttgaggg atctgttcac agtcacatag     2760

tttttaagca gaggagccag ataatttcca agtgtgacct ggactgcctc tgcatcaaag     2820

tcatatggag tgcttgttca aacagcagat tcccaggcct tattttggcc taaagaacca     2880

gagtctaggt ggtgggacat aggaatctgc atttcagtaa actttacacg tgattcttct     2940

gcacacagta ttgaagagca actagattaa attctagttt acaaaattac cagttttctt     3000

caagaactaa atgatatgtc cttttttttt ttttcaaaga ggataaggct                3050


<210> 3495
<211> 3546
<212> DNA
<213> Homo sapiens

<400> 3495
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccaacgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact     1560

catatcaacc caagtaccat gtggacttga tccctggctg aatcacctgg atgacttgga     1620

atagaaatga ctgctttaga agatgggatg gggccgggtg gtaagggata gaagagagga     1680

ctctcaatct actgatcaag tcctttcccc aatgcccagt ggatggccag ggtacctggg     1740

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1800

tagaaagggc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1860

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1920

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1980

agtgtggtgg ccactggtga cttgaaaata tagagaaaaa aaaaacctgc tctatatctg     2040

aaagagctct tgggaagaca gagaaacata aagaggaaat tacagcacag tgtggtgggt     2100

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     2160

ggaaggagag ggtgagtggg ggatggcttt ctgaaaaggg tggtctaaag gatgcctatg     2220

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     2280

ggatgacctg tgactctgga gcactgggtt gtctccattg tcattatggg cagatgtgtg     2340

ccatccccag ccgacgccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     2400

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     2460

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     2520

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2580

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaacttta     2640

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2700

ggaagagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2760

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gtgtaaacta     2820

caatgctctg tcatctccct actgggtctc ctgggaggag gggagccatc cagggtgcaa     2880

actcaaaggc agagggcaca gcgtgcttag gcccaagctt agaattcaat tgagaagttc     2940

tgttgttcat ccttacctca gcaggtagaa aagaggtgga gatcagaagc cagggattag     3000

agattgaatt gctttccctg ggagtgtgca gtatctcatt aaaatgttgt atattcaaaa     3060

aaatacagac acacacaagt gcctatataa tgataaaaca tatccaaagc acccaaacct     3120

gtgattccag aaaagtagat cctatttttg tttattttta ttggctttag ctgtgtcttt     3180

tgaaaggact attatcctct aaaatgtatg tgtatgaaga tcctggcttg cagctcggga     3240

gctttacaca ccttgtgtca ctttatcttg gtaacgagcc aagatcatgc aaccagttca     3300

tccatgtctg acccaagagc tcttaactgc tatgctgcac tgcctcattc agagatagat     3360

gcctgcatgg gtcctggcga ttattttaat gctggctaca cccccacagg tgacttggat     3420

tcagaaatac aatttatatt tcttcttttt aaattgtttt attttatttt tcttttaata     3480

gttatatgtc agtgagaaca atttatatgt cttacactga gaaataaaac tgctcataag     3540

tgaaaa                                                                3546


<210> 3496
<211> 3271
<212> DNA
<213> Homo sapiens

<400> 3496
tcagtcggcc tgcgctcctc agcctggcgg ttctacctcc gagggttcgc ccgcccttgg       60

ttttccttac accttagcct ttggctcctt tgaccactcg aagccccaca gcgtgttcca      120

gcggacttca ccagcagacc cagaagtggt gggtgaaaca ctgcctctgt tcctccttga      180

gcctgtcggg agctgctgcc tgccaccacc atgtctgctg caaatcctga gactccaaac      240

tcaaccatct ccagagaggc cagcacccag tcttcatcag ctgcagctag ccaaggctgg      300

gtgttaccag aaggcaaaat cgtgccaaac actgtttttg ttggtggaat tgatgctagg      360

atggatgaaa ctgagattgg aagctgcttt ggtagatacg gttcagtgaa agaagtgaag      420

ataatcacga atcgaactgg tgtgtccaaa ggctatggat ttgtttcgtt tgttaatgac      480

gtggatgtcc agaagatagt aggatcacag atacatttcc atggtaaaaa gctgaagctg      540

ggccctgcaa tcaggaaaca aaagttatgt gctcgtcatg tgcagccacg tcctttggta      600

gttaatcctc ctcctccacc acagtttcag aacgtctggc ggaatccaaa cactgaaacc      660

tacctgcagc cccaaatcac gccgaatcct gtaactcagc acgttcaggc ttactctgct      720

tatccacatt caccaggtca ggtcatcact ggatgtcagt tgcttgtata taattatcag      780

gaatatccta cttatcccga ttcagcattt caggtcacca ctggatatca gttgcctgta      840

tataattatc agccatttcc tgcttatcca agatcaccat ttcaggtcac tgctggatat      900

cagttgcctg tatataatta tcaggcattt cctgcttatc caaattcacc atttcaagtc      960

gccactggat atcagttccc tgtatacaat tatcagccat ttcctgctta tccaagttca     1020

ccatttcagg tcactgctgg atatcagttg cctgtatata attatcaggc atttcctgct     1080

tatccaaatt caccatttca agtcgccact ggatatcagt tccctgtata caattatcag     1140

gcatttcctg cttatccaaa ttcaccagtt caggtcacca ctggatatca gttgcctgta     1200

tacaattatc aggcatttcc tgcttatcca aattcagcag ttcaggtcac cactggatat     1260

cagttccatg tatacaatta ccagatgcca ccgcagtgcc ctgttgggga gcaaaggaga     1320

aatctgtgga ccgaagcata caaatggtgg tatcttgtct gtttaatcca gagaagagac     1380

tgataaattc cgttgttact caagatgact gcttcaaggg taaaagagtg catcgcttta     1440

gaagaagttt ggcagtattt aaatctgttg gatcctctca gctatctagt ttcatgggaa     1500

gttgctggtt ttgaatatta agctaaaagt tttccactat tacagaaatt ctgaattttg     1560

gtaaatcaca ctgaaacttt ctgtataact tgtattatta gactctctag ttttatctta     1620

acactgaaac tgttcttcat tagatgttta tttagaacct ggttctgtgt ttaatatata     1680

gtttaaagta acaaataatc gagactgaaa gaatgttaag atttatctgc aaggattttt     1740

aaaaaattga aacttgcatt ttaagtgttt aaaagcaaat actgactttc aaaaaagttt     1800

ttaaaacctg atttgaaagc taacaatttt gatagtctga acacaagcat ttcacttctc     1860

caagaagtac ctgtgaacag tacaatattt cagtattgag ctttgcattt atgatttatc     1920

tagaaattta cctcaaaagc agaattttta aaactgcatt tttaatcagt ggaactcaat     1980

gtatagttag ctttattgaa gtcttatcca aacccagtaa aacagattct aagcaaacag     2040

tccaatcagt gagtcataat gtttattcaa agtattttat cttttatcta gaatccacat     2100

atgtatgtcc aatttgattg ggatagtagt taggataact aaaattctgg gcctaatttt     2160

ttaaagaatc caagacaaac taaactttac tgggtatata accttctcaa tgagttacca     2220

ttctttttta taaaaaaaat tgttccttga aatgctaaac ttaatggctg tatgtgaaat     2280

ttgcaaaata ctggtattaa agaacgctgc agctttttta tgtcactcaa aggttaatcg     2340

gagtatctga aaggaattgt ttttataaaa acattgaagt attagttact tgctataaat     2400

agatttttat ttttgttttt tagcctgtta tatttccttc tgtaaaataa aatatgtcca     2460

gaagaggcat gttgtttcta gattaggtag tgtcctcatt ttatattgtg accacacagc     2520

tagagcacca gagccctttt gctatactca cagtcttgtt ttcccagcct cttttactag     2580

tctttcagga ggtttgctct tagaactggt gatgtaaaga atggaagtag ctgtatgagc     2640

agttcaaagg ccaagccgtg gaatggtagc aatgggatat aatacctttc taagggaaac     2700

atttgtatca gtatcatttg atctgccatg gacatgtgtt taaagtggct ttctggccct     2760

tctttcaatg gcttcttccc taaaacgtgg agactctaag ttaatgtcgt tactatgggc     2820

catattacta atgcccactg gggtctatga tttctcaaaa ttttcattcg gaatccgaag     2880

gatacagtct ttaaacttta gaattcccaa gaaggcttta ttacacctca gaaattgaaa     2940

gcaccatgac tttgtccatt aaaaaattat ccatagtttt tttagtgctt ttaacattcc     3000

gacatacatc attctgtgat taaatctcca gatttctgta aatgatacct acattctaaa     3060

gagttaattc taattattcc gatatgacct taaggaaaag taaaggaata aatttttgtc     3120

tttgttgaag tatttaatag agtaaggtaa agaagatatt aagtcccttt caaaatggaa     3180

aattaattct aaactgagaa aaatgttcct actacctatt gctgatactg tctttgcata     3240

aatgaataaa aataaacttt ttttcttcaa a                                    3271


<210> 3497
<211> 1935
<212> DNA
<213> Homo sapiens

<400> 3497
ctgccagaga ggaagagaaa agaaaggaag aaacattaga aagaaaaagg aaggaaaacg       60

gtataaagag agatcaatta cccaccctta aatagctaga ttgggggggg aggggggtgg      120

aaaagaaagc tgtggaggtg tgccccagca cggctgcttt gaaaggttta tcatctatcc      180

gtttggttta tggagaaaaa gaaaatggta actcagggta accaggagcc gacaacaact      240

cctgacgcaa tggttcagcc ttttactacc atcccatttc caccacctcc gcagaatgga      300

attcccacag agtatggggt gccacacact caagactatg ccggccagac cggtgagcat      360

aacctgacac tctacggaag tacgcaagcc cacggggagc agagcagcaa ctcacccagc      420

acacaaaatg gatctcttac gacagaaggt ggagcacaga cagacggcca gcagtcacag      480

acacaaagta gtgaaaattc agagagtaaa tctaccccga aacggctgca tgtctctaat      540

attcctttcc gcttccggga ccctgacctc cggcagatgt ttgggcagtt tggcaaaatc      600

ctagatgtag aaataatctt taatgaacgt ggctctaagg gattcgggtt cgtaactttc      660

gagaatagtg ctgatgcaga cagggccagg gagaaattac acggcaccgt ggtagagggc      720

cgtaaaatcg aggtgaataa tgctacagca cgtgtaatga ccaataagaa gatggtcaca      780

ccatatgcaa atggttggaa attaagccca gtagttggag ctgtatatgg tccggagtta      840

tatgcagcat ccagctttca agcagatgtg tccctaggca atgatgcagc agtgccccta      900

tcaggaagag ggggtatcaa cacttacatt cctttaatca gtctcccttt agttcctggc      960

ttcccttacc ctactgcagc caccacggca gccgctttca gaggagccca tttgaggggc     1020

agagggcgga cagtatatgg tgcagtccga gcggtacctc caacagccat ccccgcctat     1080

ccaggtgtgg tttaccagga cggattttac ggtgctgacc tctatggtgg atatgcagcc     1140

tacagatatg cacagcctgc tactgcaacc gcagccaccg ctgctgcagc cgctgcagcc     1200

gcttacagtg acggttatgg cagggtgtac acagccgacc cctaccatgc ccttgcccct     1260

gccgctagct atggagttgg cgctgtggcg agtttatacc gaggtggcta cagccgattt     1320

gccccctact gaagtgacgt gagacccctg caaatgggac agccccccag ttcatgaggc     1380

ctggctattg caatatttac tagtagagga actctatagc aagatgaaga ggaaaaacaa     1440

acaaacaaac aaaaaaaaac acaaaaaaag aaagaatact tttttatacc tcactatgtt     1500

ctttgaatat gtatttttcc tttaaatttc tgcctttaat tcttttgttc caaagattgt     1560

gcattttttt cttttttttt ttaaactgtg gtaaaaaaaa aaaaaataat gcatttccat     1620

gtctgtatgt ccgtgcttag cttattctat caatcacgga agaggcagtc aaggaggaag     1680

gagagacatt aggagccgat aaatgcatct gatcagaaat cagcagacag aattaccaaa     1740

gtgtatctgg tgctgaatga ctgggggaca agcagaagtg gaagagatct ttctgcaaca     1800

ggatattctt ctagtcttct gagtttctgg tctttgacag gcaattctgg ttggctgtgg     1860

ctggaatcca catgctgata gataggaatt tgtgcttaca aagcaggaga attaaaaaga     1920

cgctttcctc tcctc                                                      1935


<210> 3498
<211> 2200
<212> DNA
<213> Homo sapiens

<400> 3498
gatggacccc ggcgacgccg ccattttgga gtcttcccta aggatcctct accggctttt       60

cgagtcagtg ctgccgccgc tgcccgcggc tttgcagagc aggatgaatg tgatagacca      120

cgtgcgggac atggcggccg cggggctgca ctccaacgtg cggctcctca gcagcttgtt      180

acttacaatg agtaataaca accctgagtt attctcccca cctcagaagt accagctttt      240

ggtgtatcat gcagattctc tctttcatga taaggaatat cggaatgctg tgagtaagta      300

taccatggct ttacagcaga agaaagcgct aagtaaaact tcaaaagtga gaccttcaac      360

tggaaattct gcatctactc cacaaagtca gtgtcttcca tctgaaattg aagtgaaata      420

caaaatggct gaatgttata caatgctaaa acaagataaa gatgccattg ctatacttga      480

tgggatccct tcaagacaaa gaactcccaa aataaacatg atgctggcaa acctgtacaa      540

gaaggctggt caggagcgcc cttcagtcac cagctataag gaggtgctga ggcagtgccc      600

attagccctt gatgccattc taggcttgtt gtccctttct gtaaaagggg cagaggtggc      660

atccatgaca atgaatgtga tccaaaccgt gcctaacttg gactggctct ctgtgtggat      720

caaagcgtat gcttttgtgc acactggtga caactcaaga gcaatcagta ccatctgttc      780

actagagaaa aaatccttat tgcgagataa cgtggaccta ttgggaagct tggcagatct      840

gtacttcaga gctggagaca ataaaaactc tgtcctcaag tttgaacagg cacagatgtt      900

ggatccttat ctgataaaag gaatggatgt atatggctac ctactggcac gagaagggcg      960

gctagaggat gttgagaacc ttggatgccg ccttttcaat atctctgatc agcatgcaga     1020

accgtgggtg gtttctggct gtcacagctt ctatagcaaa cgctactccc gggccctcta     1080

tttaggagcc aaggccattc agctgaacag taatagtgtt caagctctgc tacttaaggg     1140

agcagcactt aggaacatgg gcagagtcca agaagcaata atccactttc gggaggccat     1200

acggctcgca ccttgtcgct tagattgtta tgaaggtctt atcgaatgtt acttagcctc     1260

caacagtatt cgagaagcaa tggtaatggc taacaacgtt tacaaaactc tgggagcaaa     1320

tgcacagacc cttacccttt tagccaccgt ttgtcttgaa gacccagtga cacaggagaa     1380

agccaaaaca ttattagata aagccctgac ccaaaggcca gattacatta aggctgtggt     1440

gaaaaaagca gaactactta gcagagaaca gaaatatgaa gatggaattg ctttgctgag     1500

gaacgcactg gctaatcaga gtgactgtgt cctgcatcgg atcctaggag atttccttgt     1560

agctgtcaat gagtatcagg aggcaatgga ccagtatagt atagcactaa ggtaggcact     1620

agcctccctt gggggaaggc cactgaggag ggtagaggag gcagtgagct gtgtcacagg     1680

agttatggaa acacacacac actttgtgtc catggttgaa agcagaataa taatagtaat     1740

ggtagaagag ttatttgtga attcatgact tctaaaaatt ttttcttaaa atatattaac     1800

aacattagag aactgtttca ctcataacca tcccacacca ctataacatc tgtgttcatt     1860

tgtatagctc atcttctgtc cttgcccaca cacacatatt tttatagggc tgtacctagt     1920

atatatttta tattcttctt tttcaaatca aagtattgta agtactttcc catgtttcta     1980

tctactgtag tcattaagaa cttgaggtct gaagttttga atactacctt caccacctgt     2040

gatcttgggc aagttactaa cacatttcct tgtctatatc tagctacctt attagatatt     2100

aaatgatcga atgagggtta aatgattatt tcatgtaaag ctcttagccc tgtgcctggt     2160

acatagtaaa tgctaaataa atagtggtat tcttactgtt                           2200


<210> 3499
<211> 649
<212> DNA
<213> Homo sapiens

<400> 3499
aagagggata attcctccca agatcaattt agcaaaatag cggcactgtc gggatcacac       60

attcaggtcc tgaatgtgag gctgccagca gtttcattaa cctaatccca ggctccttcc      120

tcccgcacct gagggttgct caggcctccc tcaaactagc caatgagaag tgcacgggtc      180

ctggtcgcct aggaaaccgc gtgacaacaa gatggcggcg ctgcgggacg gctagcggcc      240

ctgcgtggag gcgaggaatc cgcatctatg gagatgtccc tgcatcccat gactcggagc      300

tgatggcctt catgacgagg aagttgtggg acctggagca gcaggtgaag gcccagactg      360

atgagatact gtccaaggat cagaagatag cggccctaga ggacctggtg cagaccctcc      420

ggccacaccc agccgaggca accctgcagc ggcaggagga actggagacg atgtgtgtgc      480

agctgcagcg gcaggtcagg gagatggagc ggttcctcag tgactatggc ctgcagtggg      540

tgggcgagcc catggaccag gaggactcag agagcaagac agtctcagag catggcgaga      600

gggactggat gacagccaag aagttctgga agccaggtag agcagggcg                  649


<210> 3500
<211> 553
<212> DNA
<213> Homo sapiens

<400> 3500
agaaggagca gccccccacc tggctaccgc agccctctct ggttctgtgc agggtattgg       60

gatgcgttac tgaggcccaa atctgcccca ctgggaaccc ccaaaaaaga gccagggcag      120

gagaatgaga gggaggagcc atgaaacccc cgccctttaa agacagctct gtggcagctg      180

gcccaggccc tgcagccctc accacgttgg gactcacttg ggggtctccc atgggggtcc      240

taatcccatc tcttttcttc ccagtccaga atgacagggt ccagaaactg gcgagccacg      300

agggacatgt gtaggtatcg gcacaactat ccggatctgg tggaacgaga ctgcaatggg      360

gacacgccaa acctgagttt ctacagaaat gagatccgct tcctgcccaa cggctgtttc      420

attgaggaca ttcttcagaa ctggacggac aactatgacc tccttgagga caatcactcc      480

tacatccagt ggctgtttcc tctgcgagaa ccaggagtga actggcatgc caagcccctc      540

acgctcaggg agg                                                         553


<210> 3501
<211> 1353
<212> DNA
<213> Homo sapiens

<400> 3501
ttggactgag gagcggaccc ggccgggcgc aggggctgga ctggcggagc aggtggggtc       60

cgcggccgcc ggagcgttcc ggtcggcgtc tgggcatctc ggcctcggca gaaagcgcga      120

cggccctgct gcgcggggcc cgcggcgatg ccgttcctgc acggcttccg gaggatcatc      180

ttcgagtacc agccgctggt ggatgcgatt ctgggctccc tggggatcca ggaccccgag      240

cggcaggagt ctctggaccg acccagtcac ctactacacg gccttgcaca tcgccgtcct      300

gcggaaccag ccggacatgg tggagctgct ggtgcatcac ggggccgacg ttaatcggag      360

ggaccggatc cacgagagta gccccttgga cctggccagc gaggagcctg agcgcctgcc      420

ctgcctgcag cgcctcctgg accttggagc tgatgtcaat gccgctgaca agcatggaaa      480

aactgctctg ctccatgctc tggccagcag cgacggggtg cagatccaca atactgagaa      540

cattcgtctc ttactggaag gaggggcaga cgtcaaggcc accaccaaag atggggacac      600

agtgttcacc tgcatcatct tcctgcttgg tgagaccgtg ggaggggaca aagaggaggc      660

ccagatgatc aaccgcttct gcttccaagt cacacggctg ctgctggcac acggggccga      720

ccccagcgag tgcccagccc acgagtccct cacccacatc tgcctgaaga gctttaaact      780

gcacttccct ctcctgcgct tcctcctgga gtccggagcc gcctacaact gctccctgca      840

cggtgcgtcc tgctggtctg gctttcacat catctttgag aggctctgtt cccacccagg      900

ctgcacggaa gacgagagcc atgcggacct cctgcgcaaa gctgagactg tcctggatct      960

catggtgacc aactctcaga aactccagct gcccgaaaac ttcgatatcc accctgtggg     1020

cagcctggcg gaaaagatcc aggccctcca cttctccttg aggcagctgg agagctatcc     1080

cccgcccctc aagcacctgt gccgtgtggc catccggctc taccttcagc cgtggcctgt     1140

ggatgtgaag gtcaaagccc tgcctctgcc cgacaggctg aagtggtacc tccttagcga     1200

gcacagtggc tccgtggaag atgacatctg ataggtctca ggctacagga acgggggaca     1260

cgggcagctc aggtcagcct gttggtagat gctgggacag cattagaaga gggtcttttt     1320

gatctgggag atgagacggg atccttcatg aga                                  1353


<210> 3502
<211> 4073
<212> DNA
<213> Homo sapiens

<400> 3502
gccagctgct gcgcatgcgc cggccggggc cccgccccca tgcgccgcgc ggctccaggg       60

ccacgttcca gggtcgggtt tggtggattc ctcagtccct gccgccgcgg ggcgccctgg      120

gatagcggcg gggcctcctg gtgagcgcgc gccggggcgg cctccgggaa gtgggagacg      180

ctgcgggtcc tgggcccagg ccttgggatg ggcgggaagg cctggccgcg ccgggctgtg      240

ggcactgcag gaggcccctg tgcaggtgga gatcgccgcg gccctggcgg gactctttgc      300

tggctcttgg gcgcgctgat gcccatcatc tccctgagtt tctgagccct atctctcatg      360

tgtcagtggt caccgccgaa tccagacact ccggccctgt tccggaagag ccctgatatc      420

cgtggctcca tggcgctgtc tgtcgatacc atgcactcta gctctcaagg aggaaaggtt      480

ttgtggaagg gaatagagac ttggaataac agacctgtgc taattagaga cgggaaagat      540

ggaacaaggg gagtgaccct tctccacccc catatcctaa tgtgctctct ctctatccag      600

aacagatctc ggcccctttc caaacactcc tgatgcctca tttgcctctc gcttcttttc      660

gaccaccatt ttgggggctg aggcactcac ggggcctccc caggtttcac tccgtttcta      720

cacagtcgga gccccatgga tctcccatct cccggaggaa ccgtgaagcc aaacagaagc      780

gcctgcgaga gaagcaggct actctggagg ctgagatagc aggggagagc aagtcacctg      840

cagaatccat taaggcctgg aggcctaagg agttagtatt gtatgaaatc cctacgaaac      900

ccggtgaaaa gaaagatgtc tctgggcccc tgcctcctgc atacagcccc cgatatgttg      960

aggctgcctg gtacccgtgg tgggtacgag agggcttctt caaaccagaa tatcaggccc     1020

ggctgcccca agctacaggg gagacctttt ccatgtgtat cccacctccc aatgtcactg     1080

gctccctgca cattggccac gcactcacgg tggccataca ggatgccctc gtgcgctggc     1140

accggatgcg tggggatcaa gtgctgtggg tccctggttc agatcatgca ggaattgcta     1200

cacaagctgt ggtggagaaa caactgtgga aggaacgggg agtgaggaga catgagctga     1260

gccgggaggc cttccttagg gaggtgtggc agtggaagga ggcgaaaggt ggagagatct     1320

gtgagcagct gcgagctctg ggtgcctccc tggactggga tcgagagtgt tttaccatgg     1380

atgttggctc ctcagtggct gtgactgaag cttttgtgcg gctctacaag gcggggttgc     1440

tgtaccggaa ccatcagctt gtcaactggt catgtgcttt aagatcagcc atctcggaca     1500

ttgaggtgga gaaccggccc ctgcctggcc acacacagct tcgactgcct ggctgcccca     1560

cccccgtgtc ttttggcctc ctattttctg ttgccttccc cgtggatgga gagcctgatg     1620

cagaggttgt ggtaggaacc acaaggccag agacgctgcc tggagatgtg gctgtggccg     1680

ttcatccaga cgactcgcga tacacacatc tacacgggcg acagcttcgt caccccttga     1740

tggggcagcc tcttcccctc atcacagact atgctgttca gccacatgtg ggcacggggg     1800

cagtgaaggt gactccagct cacagtcctg ccgatgctga gatgggggcc cgacatggct     1860

tgagcccctt gaatgtcatt gcggaggatg ggaccatgac ctccctctgc ggggactggt     1920

tgcagggtct tcaccggttt gtggcccggg aaaagataat gtctgtgctg agtgaacggg     1980

gcctattccg gggcctccag aaccacccca tggtactgcc catctgcagc cgttctgggg     2040

atgtgataga atacctgctg aagaaccagt ggtttgtccg ctgccaggaa atgggggccc     2100

gagctgccaa ggctgtggag tcgggggccc tggagctcag tccctccttc caccagaaga     2160

actggcagca ctggttttcc catattgggg actggtgtgt ctcccggcag ctgtggtggg     2220

gccatcagat tccagcctac ctggttgtag aggaccatgc gcagggagaa gaggactgtt     2280

gggtggttgg gcggtcagag gctgaggcca gagaggtagc agcggaactg acagggaggc     2340

caggggcaga gctgaccctg gagagggatc ctgatgtcct agacacatgg ttttcttctg     2400

ccctgttccc cttttctgcc ctgggctggc cccaagagac cccagacctt gctcgtttct     2460

accccctgtc acttttggaa acgggcagcg accttctgct gttctgggtg ggccgcatgg     2520

tcatgttggg gacccagctc acagggcagc tgcccttcag caaggtgctt cttcatccca     2580

tggttcggga caggcagggc cggaagatga gcaagtccct ggggaatgtg ctggacccaa     2640

gagacatcat cagtggggtg gagatgcagt tgctgcagga aaagctgaga agcggaaatt     2700

tggaccctgc agagctggcc attgtggctg cagcacagaa aaaggacttt cctcacggga     2760

tccctgagtg tgggacagat gccctgagat tcacactctg ctcccatgga gttcaggcgg     2820

gcgacttgca cctgtcagtc tctgaggtcc agagctgccg acatttctgc aacaagatct     2880

ggaatgctct tcgctttatc ctcaatgctt taggggagaa atttgtgcca cagcctgctg     2940

aggagctgtc tccctcctcc ccgatggatg cctggatcct gagccgcctt gccctggctg     3000

cccaggagtg tgagcggggc ttcctcaccc gagagctctc gctcgtcact catgccctgc     3060

accacttctg gcttcacaac ctctgtgacg tctacctgga ggctgtgaag cccgtgctgt     3120

ggcactcgcc ccgccccctg gggccccctc aggtcctgtt ctcctgcgct gacctcggcc     3180

tccgcctcct ggccccactg atgcccttcc tggctgaaga gctctggcag aggctgcccc     3240

ccaggcctgg ttgcccccct gcccccagca tctcggttgc cccctaccct agcgcctgca     3300

gcttggagca ctggcgccag ccagagctgg agcggcgctt ctcccgggtc caagaggtcg     3360

tgcaggtgct aagggctctc cgagccacgt accagctcac caaagcccgg ccccgagtgc     3420

tgctgcagag ctcagagcct ggggaccagg gcctcttcga ggccttcttg gagcccctgg     3480

gcaccctggg ctactgtggg gctgtgggcc tgttaccccc aggcacagca gctccctccg     3540

gctgggccca ggctccactc agtgacacgg ctcaagtcta catggagctg cagggcctgg     3600

tggacccgca gatccagcta cctctgttag ccgcccgaag gtacaagttg cagaagcagc     3660

ttgatagcct cacagccagg accccatcag aaggggaggc agggactcag aggcaacaaa     3720

agctttcttc cctccagctg gaattgtcaa aactggacaa ggcagcctct cacctccggc     3780

agctgatgga tgagcctcca gccccaggga gcccggagct ctaactcatc atccccatca     3840

gttttcctcc ctctcagacc tgtctttgag gacaaacaga tttgtcagct gtcagggtgc     3900

agtgggacgt cagagactat gtggtccatc gccttcattg tgtaaatgag gacacagact     3960

ggcttggtcg cagtgactgt ggtgtccttg agatgctcac attactgccc ggcctgcctc     4020

ccacctggaa gtctgggaat gaggagattg agataaactt ttgaaatccc aaa            4073


<210> 3503
<211> 560
<212> DNA
<213> Homo sapiens

<400> 3503
agaccaaggt gagcagctcc tacccgatgc ttggctcttg attctcaggg tcgcggagaa       60

ctggccgcgg gcgtccgggg ccgggaacag aaagcgggac ctgggggcca tgggggatcc      120

ggacagagac cgcgcttgga cgtgcacggg cctggcgttc gctggtgctc agcatacggc      180

gcggtgagga gcggcgagca cccggacgtc acctggcctg gtagggaacg gaacccgggg      240

cgcacaacgc tatgggcggc cctgccaggc ctctgctccg agtacgggaa accgcgattt      300

taatgcggct catcgcgaaa gcttcgtcgt tttgtctggc tctctttaac acttttgtga      360

gaggaaaaat tggcttgcaa tacatctcgc tggctgtttg cggctactat cagaagttga      420

attctaataa ttagctattt tataaaggta acgagaaaaa atacactatg tctgatgaag      480

tttttagcac cactttggca tatacaaaga gtccaaaagt taccaaaaga actactttcc      540

aggatgagct aataagagca                                                  560


<210> 3504
<211> 2534
<212> DNA
<213> Homo sapiens

<400> 3504
aaactcactg aaaatcaaac cgctaccatt aggagccctc cacgcttaac atatccgttc       60

tttctcgttt gaaagtaacc aggctgctcc tccccatttt tcgccttctt ctcgcggagg      120

ctgagagact aaccttacac aacatggcgg cctggtgtgt ctggtgtcct agagcggacg      180

aaagcaggtg actctctagt caacttccga cttggactcc gaagatcgct acagaaagat      240

ctagaagagg taaaggtgtt gctggaaaag gctactagga aaagagtacg tgatgccctt      300

acagctgaaa aatccaagat tgagacagaa atcaagaaca agatgcaaca aatcacagaa      360

gaaagcagaa cttcttgata atgaaaaacc agctgctgtg gttgctccca ttacaacggg      420

ctatacggtg aaaatcagta attatggatg ggatcagtca gataagtttg tgaaaatcta      480

cattacctta actggagttc atcaagttcc cactgagaat gtgcaggtgc atttcacaga      540

gaggtcattt gatcttttgg taaagaatct aaatgggaag agttactcca tgattgtgaa      600

caatctcttg aaacccatct ctgtggaagg cagttcaaaa aaagtcaaga ctgatacagt      660

tcttatattg tgtagaaaga aagtggaaaa cacaaggtgg gattacctga cccaggttga      720

aaaggagtgc aaagaaaaag agaagccctc ctatgacact gaaacagatc ctagtgaggg      780

attgatgaat gttctaaaga aaatttatga agatggagac gatgatatga agcgaaccat      840

taataaagcc tgggtggaat caagagagaa gcaagccaaa ggagacacgg aattttgaga      900

ctttaaagtc gttttgggaa ctgtgatgtg atgtggaaat actgatgttt ccagtaaggg      960

aatattggtg agctgcatat ataaatttga cagatagcta tttacatagc cttctaagta     1020

aaggcaatga attctccatt tcctactgga ggatttattt aaataaaata tgcttattaa     1080

acactcctgc aaagatggtt ttattagtac cctggtcatt ttgttcaagg aagggttata     1140

ttgcattctc acgtgaaata taaaaagcaa gtcttgccca ataaaaacgc tacattgtgt     1200

gtattttttg ttcagctaag aattggaaaa gtatttgctt gccttttaag ttactgacat     1260

cagcttccac cagtgtaaaa attgagtaaa acctgaagtt ttgcataaaa tgcaaatcgg     1320

tgcctgtgct tgaaggttgc tgtagagcat ctgacccctt attaccacct taagcaatgt     1380

atatgccatg cattaccatg cactaattca atcacaggtg tttctatcta gatttaaata     1440

tatttgtcaa tgaatgtgga atagaaaatc taaacatgac aataatagac atatctttgt     1500

atggtaccag ttagttttgc cgtggatcag atggtttata aaagtaataa ccataaagca     1560

aaaaataatt tgaaagcccg tctattccta tgctcaataa agttaagttt ttcttcatta     1620

gaacagtttt atgatttatt tgtctaggag tatgtcagaa aaatcaggct tttagtagga     1680

attactccta ttccccctga agtcaggacc agtgcctgtg atctccatta ctttattttc     1740

ctggaggtat tagccaacac agttagatca gagaaagcaa ttgaagccag gcatgaaggc     1800

tggcgcccgt aatcccagct actaaggctg gaggatcact tcagcccagg agtttaaggc     1860

tgcagtgagc tatgatgatg ccactgtact gcagcttggg taacagattg agaacctgtc     1920

tcattaaaaa aaaaaaaaaa aaaaaagccg ttagacacac aggaaaaatc cagaagggta     1980

aactaaacta aagctacaat taatatggga atttggaaga agtggtagga tttaaaatac     2040

agaaacagtt tatgtatagg atagctataa gtaaatactg aaacacatta tgcctctgta     2100

attggggttg acacatgaac agaatagcag acacaatgca tatgaaagtt acagaatatg     2160

gtaaaagtgg ggtaaagatg ggtttttaat gatactaaga taactgaaaa taggcatata     2220

gatatattcc aagccgcctg acgatctaat tgtaaaaagt aaagcataca aatactagaa     2280

gaaaatggag gaaaacgaca ttatatgtga cttaaaacct agaagaaata aataaaacta     2340

ttgatcaatt ttaactacat aaaaatgttt ataggacaag aaaaacccca ccataaccca     2400

aggcaaacaa tgtattgaca ggattccaat aattaagaat acttcataca aaaagaaatg     2460

taaatgacct ttaacatgta aagatgctca ccttgttcag aagagaataa accagtgttt     2520

ttacctttca cttg                                                       2534


<210> 3505
<211> 682
<212> DNA
<213> Homo sapiens

<400> 3505
ggaaacctgt tgagatcaca gagaatatac tgacggcata aaagggcaga accatagcag       60

ggtgcgcctc gcagtcacct ctgtgccctg ctggttgtct tcccagcgct gctgtagttg      120

ccttccatgg atctatagga gagcaagtcc tccaggagaa gaagtcctca ccagtgaacg      180

gagacctctc tgaactaagg ataccatggc cacgtcagcc ccactacgga gcctggaaga      240

ggaggtgacc tgctccatct gtcttgatta cctgcgggac cctgtgacca ttgactgtgg      300

ccacgtcttc tgccgcagct gcaccacaga cgtccgcccc atctcaggga gccgccccgt      360

ctgcccactc tgcaagaagc cttttaagaa ggagaacatc cgacccgtgt ggcaactgga      420

aaaaatcctg aaccacctga gtaccctaag gagagacaga gacaaaattc agggcttcca      480

ggcaaaggga gaagctgata tcctggccgc gctgaagaag ctccaggacc agaggcagta      540

cattgtggct gagtttgagc agggtcatca gttcctgagg gagcgggagg aacacctgct      600

ggaacagctg gcgaagctgg agcaggagct cacggagggc agggagaagt tcaagagccg      660

gggcgtcggg gagcttgccc gg                                               682


<210> 3506
<211> 5029
<212> DNA
<213> Homo sapiens

<400> 3506
actttttatc catgccagtg tcagcttctc tccgaaaact gggtaatacg aaatggtctt       60

tattggttgt gaacactcga gctgagaaac attttaggat ctttgtgtct tttgtgatga      120

ttttgtttct gaagaggaag ctgtctaaaa tattcaagtg tgcaaccaag gatttagatg      180

aagccagcaa acaaaggaat catgtaatca ggacctgagc gaatgtgctt actcacggcg      240

ttagttacac aggtgatttc cttaagaaaa aatgcagaga gaacttgttt atgcaagagg      300

agatggccct ggggcccctc gccccggatc tactgctcat ccaccccatg cgattccaaa      360

ttccccaccg tctactccag tgccccattc catgcccccc tccccgtcca gaattcctta      420

tgggggcacc cgctccatgg ttgttcctgg caatgccacc atccccaggg acagaatctc      480

cagcctgcca gtctccagac ccatctctcc aagcccaagc gccattttag aaagaagaga      540

tgtcaagcct gatgaagaca tgagtggcaa aaacattgca atgtacagaa atgagggttt      600

ctatgctgat ccttaccttt atcacgaggg acggatgagc atagcctcat cccatggtgg      660

acacccactg gatgtccccg accacatcat tgcatatcac cgcaccgcca tccggtcagc      720

gagtgcttat tgtaacccct caatgcaagc ggaaatgcat atggaacaat cactgtacag      780

acagaaatca aggaaatatc cggatagcca tttgcctaca ctgggctcca aaacaccccc      840

tgcctctcct cacagagtca gtgacctgag gatgatagac atgcacgctc actataatgc      900

ccacggcccc cctcacacca tgcagccaga ccgggcctct ccgagccgcc aggcctttaa      960

aaaggagcca ggcaccttgg tgtatataga aaagccacgg agcgctgcag gattatccag     1020

ccttgtagac ctcggccctc ctctaatgga gaagcaagtt tttgcctaca gcacggcgac     1080

aatacccaaa gacagagaga ccagcgagaa aatgatgaaa accacagcca acaggaacca     1140

cacagatagt gcaggaacgc cccatgtgtc tggtgggaag atgctcagtg ctctggagtc     1200

cacggtgcct cccagccagc ctccacctgt gggcacctca gccatccaca tgagcctgct     1260

tgagatgagg cggagcgtgg cggaactcag gctccagctc cagcagatgc ggcagctcca     1320

gctgcagaac caggagttgc tgagggcaat gatgaagaag gccgagctgg aaatcagtgg     1380

caaagtgatg gaaacaatga agagactgga ggatcccgtg cagcgacagc gcgtcctagt     1440

ggagcaagag agacaaaaat atcttcatga ggaagagaag atcgtcaaga agttgtgcga     1500

gttggaagac tttgttgaag acttgaagaa ggactccacg gcagccagcc gattggttac     1560

tctgaaagac gtggaagacg gggctttcct cctgcgtcaa gtgggagagg ctgtagctac     1620

cctgaaagga gaatttccaa ccttacaaaa caagatgcga gccatcctgc gcatagaagt     1680

ggaggccgtg cggtttctga aggaggagcc acacaagctg gacagtctcc tgaagcgtgt     1740

gcgcagcatg acagacgtcc tgaccatgct gcggagacat gtcactgatg ggctcctgaa     1800

aggcacggac gcagcccaag ccgcacagta catggctatg gaaaaggcca cagccgcaga     1860

agtcctgaag agtcaggagg aggcagccca cacctccggc cagcccttcc acagcacagg     1920

tgcccctggc gatgcgaagt cggaagtggt gcctttgtcc ggcatgatgg ttcgccacgc     1980

gcagagctcc cctgtggtca tccagccctc ccagcactcc gtggccctgc tgaaccctgc     2040

tcagaacttg cctcacgtgg ccagctcccc agccgtcccc caggaagcaa cctccactct     2100

gcagatgtcg caggctccgc agtccccaca gatacccatg aatgggtctg ccatgcagag     2160

cttgttcatt gaagaaatcc acagtgtgag tgccaagaac agggcagtgt ctatcgagaa     2220

agcagaaaag aaatgggagg aaaaaaggca aaatctggat cactataatg ggaaagagtt     2280

tgagaagctc ctagaagaag ctcaggccaa tatcatgaag tcaataccaa atctggagat     2340

gccgccagcc acaggcccac tgccaagggg agatgcccca gtggacaagg tggaactttc     2400

agaagattct ccaaattcgg aacaggactt ggaaaagctg gggggaaagt cgccccctcc     2460

tcctccgcca cctcctcgtc gaagctacct gccaggatcg ggactcacca ccacgaggtc     2520

aggcgatgtg gtctacaccg gcagaaagga gaacatcacc gctaaggcaa gcagtgaaga     2580

tgctggacca agcccacaga ccagagctac aaaatatcca gcagaggagc ctgcttcagc     2640

ctggacccca tccccaccgc ctgtcaccac ctcctcctca aaggatgagg aggaagaaga     2700

agaagaagga gacaaaataa tggcagaact ccaggcattc cagaagtgtt cctttatgga     2760

tgtaaattca aacagtcatg ctgagccatc ccgggctgac agtcacgtta aagacactag     2820

gtcgggcgcc acagtgccac ccaaggagaa gaagaatttg gaatttttcc atgaagatgt     2880

acggaaatct gatgttgaat atgaaaatgg cccccaaatg gaattccaaa aggttaccac     2940

aggggctgta agacctagtg accctcctaa gtgggaaaga ggaatggaga atagtatttc     3000

tgatgcatca agaacatcag aatataaaac tgagatcata atgaaggaaa attccatatc     3060

caatatgagt ttactcagag acagtagaaa ctattcccag gaaactgtgc ctaaggccag     3120

tttcggtttc tctggcatta gtccattaga agatgaaata aacaaagggt ctaaaatctc     3180

aggcctgcaa tactctatac ctgacaccga gaaccagacg ctgaattacg gaaagacaaa     3240

ggagatggaa aagcaaaata cggataagtg tcacgtttcc tctcacacta gactaacaga     3300

atcaagcgtg catgatttta aaacagaaga tcaagaggtt atcacgacag attttggcca     3360

agttgttcta agacccaagg aggcaaggca tgctaacgtg aaccctaatg aggatggaga     3420

atcaagttca agttctccca ctgaagaaaa tgcagccact gacaatattg ccttcatgat     3480

taccgaaacc actgtccagg ttctttccag tggggaggtg catgatattg ttagccaaaa     3540

gggagaagac atacagacgg ttaatatcga tgccagaaaa gagatgaccc cccgacaaga     3600

agggactgac aatgaggatc cagtcgtgtg cctggacaag aaaccagtga tcatcatttt     3660

cgatgagccc atggacatcc ggtctgccta taagagactt tcaactatct ttgaggaatg     3720

tgatgaggaa ttagagagaa tgatgatgga ggaaaagata gaggaggagg aagaggagga     3780

aaatggggat tctgtagtcc agaataataa cacttcccag atgtctcata agaaggtggc     3840

cccaggcaat cttagaaccg gacaacaggt ggaaacaaag tcacagccac actccctggc     3900

cacagagacc agaaacccag gaggacagga aatgaacaga acggagctga acaagttcag     3960

ccacgtggat tctccaaatt cggaatgcaa gggtgaggac gcgaccgatg accagtttga     4020

aagccccaag aaaaagttta aattcaaatt ccctaagaag caactcgccg ctctcactca     4080

agccattcgc accggaacta aaacagggaa gaagactttg caagtggtag tctatgaaga     4140

agaggaagag gatggcaccc tgaaacagca caaagaagcc aagcgcttcg aaatcgctag     4200

gtctcaacct gaagacaccc ctacgtcgat accttcagct tcacgtaagg gctccagcgg     4260

ggccccacag acgagcagga tgcctgtccc catgagtgcc aagaacagac ccggaaccct     4320

ggacaaaccc ggcaagcagt ccaaactgca ggatccccgc caatatcgtc aggctaatgg     4380

aagtgctaag aaatctggtg gggactttaa gcctacttcc ccctccttac ctgcttctaa     4440

gattccagcc ctttctccca gctctgggaa aagcagttct ctgccctctt ctagtggtga     4500

cagctctaac ctccctaatc cacctgctac taaaccatcg attgcttcta accctctcag     4560

cccccaaaca ggaccacctg ctcactctgc ctccctcatc ccttctgtct ctaatggctc     4620

tttgaagttt cagagcctca ctcatacagg taaaggtcac catctttcat tctcaccgca     4680

gagtcaaaat ggccgagcac cccctccttt gtcattttcc tcctcccctc cttctcctgc     4740

ctcctccgtc tcactgaatc aaggtgccaa gggcaccagg accatccata ctcccagcct     4800

caccagctac aaggcacaga atggaagttc aagcaaagcc accccatcca cagcaaaaga     4860

aacctcttaa aggtcaaatc ctattaggca caagtcggag ttacatttaa aaaaaattaa     4920

cagtctacaa caactgtttt cacaagagaa tgtaacatat tgctgtatcg tttgaggctt     4980

aatgctaaat atgtgctaaa tactggatta atagatttca gtaaagctc                 5029


<210> 3507
<211> 7982
<212> DNA
<213> Homo sapiens

<400> 3507
ggggattggc ggagcgcgag gagagaatgt gacaagtgcc ggctcggcgg ccgccggggg       60

aggccgcgcg cacctgtccc tgcccgtctc gcgccgcccg cggccgctcg gacgcgcgca      120

gagccgcccc ccgccgctgc cgccgcgtgc gcccgcgaac atgacttctg ccttcaagct      180

ggatttcctc ccggacatga tggtcgaggg ccgcctgctc gttcctgaca gaattaacgg      240

cacagccaac aagatgaacg gagctttgga tcactcagac caaccagacc cagatgccat      300

taagatgttt gtcggacaga tcccccggtc atggtcggaa aaggagctga aagaactttt      360

tgagccttac ggagccgtct accagatcaa cgtcctccgg gaccggagtc agaaccctcc      420

gcagagtaaa ggttgttgtt tcgtaacatt ttatacaaga aaagctgcac ttgaggccca      480

gaatgcactg cacaatatta aaactttacc tgggatgcat catcccattc agatgaaacc      540

tgcagatagt gaaaagtcca acgctgtgga agacagaaaa ttgttcatag gaatggtatc      600

gaagaaatgt aatgagaacg acatcagggt gatgttctct ccatttggcc agatagaaga      660

atgccggatc ctccggggac ctgatgggct gagtcgaggc tgtgcgtttg tcacattttc      720

tacaagggca atggcacaga atgcaatcaa agccatgcat cagtctcaga ccatggaggg      780

ctgctcttca cctatcgtgg tgaagtttgc tgacactcag aaggacaaag agcaaaggcg      840

cctccagcag cagctcgctc agcagatgca gcagctcaac actgccacct gggggaacct      900

gacagggctg ggcggactga ccccacagta tctggcgctc ctgcagcagg ccacctcctc      960

cagcaacctg ggtgcgttca gcggcattca acaaatggca ggcatgaatg ctttacagtt     1020

gcagaacctg gcgacgctgg ctgctgctgc agctgcggcc cagacctcag ccaccagcac     1080

caatgcaaac cctctctcta ccacgagcag cgccctggga gccctcacga gtcccgtggc     1140

tgcttcaacc cccaactcca ctgctggtgc agccatgaac tccttgacct ctctcgggac     1200

tctgcaagga ctggctggag ccactgttgg actgaataat attaatgcac tagcagttgc     1260

tcaaatgctc tcaggtatgg cggctctgaa tggaggactt ggcgccacag gcttgacgaa     1320

tggcacggct ggcaccatgg acgccctcac ccaggcctac tcaggaattc aacagtacgc     1380

agccgccgcg ctgcccactc tgtacagcca gagcctgctg cagcagcaga gcgctgcagg     1440

cagccagaag gaaggtccag agggggcaaa cctctttatt taccaccttc cacaggaatt     1500

tggagaccag gacattctgc agatgttcat gccttttgga aatgttatct ctgctaaagt     1560

cttcattgac aaacagacca atctgagcaa gtgctttggt tttgttagct acgacaatcc     1620

agtctctgca caagctgcta tccaagctat gaatggcttt cagatcggca tgaaacgctt     1680

gaaggtgcag ctgaagcgtt ccaaaaacga cagcaaacct tactgatcct aaccccagag     1740

gctccctgct ctcattttag ctttcttagg acatcttcat gcccgttagt tcatcgtttg     1800

cctagcatgt ccctgtggcg tctcaaaaaa aagtttcatc gtcccgtcat tgtttctgat     1860

gtctttctga cctcacatca tatttggttc tcctactgac ctttgatcta gtttgacctt     1920

tgaaatttgc atgtgacctc atctagctat gaattctggg aagtcaatgt gaaaaacatt     1980

gctgcattca tgcaagactg aaatttatta ttagacaaat tcattataga aaaaacctgt     2040

ggcaaaaacg tttctttctt attttttttc ttttcctaaa acagacttga aagtattata     2100

cagggattgg cattcttccc ggtcactggt aacaatagca atatgtgtcc agggacacag     2160

aatgttggtt tctaacagac tacttccaaa aacagtttga gaaaaaaact gtctgatttt     2220

aagtctctag aggtctgtaa tagtttttac atttttcagg cagtgtaaag ttttttgata     2280

aggccatttt aggtggctca ctttctcatt aagatatata tatagaacca ctttttgtag     2340

attagtataa gaaaaatatt taccctgttt tggggcaaat gctacctatt tgtgtcacct     2400

tttgctgaac tcacagttag acaatccatg gtttaatgca catgaaatta cctatatttt     2460

atactgtttc aatgtacagg agaaaggtta ctgtaaactg tgttatgttg gtgcttctgt     2520

gaattaagtt gtggtttcat catgagtctt aatgttcttt gttgataaga caagtttaga     2580

attggtttac ttaatacaaa aaaaaaaaaa agaatttcaa aaaaaaaagt tgtttgctta     2640

aaaaaaattt catgtgaggg aaaaaaaaaa aacctattcc agaataagtt ttgtgttggc     2700

ttgtgaagca ttgatgtcat tttttttaat tgtggactat ttagatgtgt ttgtgttcag     2760

caaaatgtga tgtttttttc ttttaaagaa aaaaagtgaa aatatatagt gccaaattcc     2820

aaaggtactt ccttcctaga gcttcagtgt gtttcttgtg agaagtaatt tgataacatg     2880

ggtattttat tatgtgtttt gtataaatcc ctaatattta aaaaaaaaaa caaaacaaaa     2940

aaaggttaca aagtttgtta acttgctatc ctgtggtctt gttgcctgaa attgttattg     3000

tttgttattt ctctctgatg ttttttgtaa gacattgtat aagtgcccat gtcccacttt     3060

tttaaccact ccgcacatca gtgctgtgaa ggcaacctca ccatgtattt tcttcataat     3120

ctatggaaac ctctaaggtg agaaagtttt gaacttttaa ccctttctac ccagagctat     3180

ctggaatgtt gatgactttt tatactgtca tgatttgagt ttgttttggg gtgtttccaa     3240

tttggatttt tttccctgca tctatcctct aagttgtttc ggtttgacta ctttgttctt     3300

tggttaagat ccaaaagaaa acagaaaaca attccacgag gccaatctaa agggaaaaaa     3360

tcctacacta cttttactac ttttgattat ttctcatttt tgggaaaaga attcctaatg     3420

tgctactaga attccttctt cagttttaac gagtaattgg ataaaccctg agggaaaacg     3480

gaggtagatt cagcacctaa caatcctgta tgcttttgag atcacgttta gtgctatgtc     3540

ctagtctaga atattttcat ataccttgca gtaaaacgac tttgtggcag gacagtctct     3600

tgaggggttt tgtttctgtt tcctaaatac tcctaaataa tatttctaat cagccattat     3660

gctggggcat ctctgatccc agtaggtacc tctgaatata ccaggtgtct ggagttagaa     3720

gcccatagcc ctttcccagc ctttttggtt tttttaattg aacacatttc atctaagtaa     3780

agctcagttc tttatcacaa tttactgacc aaatacctag caccagttcc tgctgccact     3840

ttttaaagtg ccatatgact ttctacgaac aggtaccttg ctgtcttgac aaatcctaat     3900

gtcacgccta cagccccaac acaagctcca gtcttcctct tcggcatgcc ctggaagctt     3960

cttggcctca gctccccttc cccgctcagc accctgttag gatcagtgtg tgtggatggg     4020

atagccctgg gatggaaagg actagcctct actgatgcaa aaaaacaaaa agcaacacaa     4080

acgtttcctt cttatagcac atgcacttcc ttacaatgac atgatttgta ttatcctcac     4140

atgtgtttac tactgctggg gccttccttc atcctctgag ggctattttg tactttctgc     4200

agcaatcagc ttaataacaa cacttattgc acctgtctct ctctgagaac acggtgtgtc     4260

tcgacacgta ccacgtacgt ggaaacacaa gagcccacca cttgaatttc taagaccatt     4320

tcattctgaa acttcttatc aattacctaa atctcaacga aaaacaattt actgaagccg     4380

actcccctcc ccatctccct ctcaacctca acccacctgc atgcatctcc cccagaggaa     4440

acactgaggg taggggacag gaggctcagg acgcgccctc tgaatcgagt gtttcttctt     4500

cacaagtcac caagagagga catgaggggg aaagtccttt ttgcccttct ccaaaaaata     4560

accttccaca gagacaaact gtccttctat ccacttttat cttttaataa atatcaaaag     4620

gaaaaagctg caagggtgca aagggcctgt gccagaagaa aacacacaca gggaaaccgc     4680

tttttttaat caattgtaga gaatagtcat ttttaatcta aattagagaa ttgtgataca     4740

atggcagtcc tcaaaggcgt aacgagttca tctttctttc accatagggg ttatagttgg     4800

cttgtgctac tctggaatca ttttactgtt tgtttttatt atcttaagtg ctaattaaaa     4860

aaaaaataaa attttaaaaa aacctgtagt ttcattacct ttttgaataa tgtcatacaa     4920

aaaatgtatt tgtttttttg tgctgtgaga attgatgttt gtagattaat aatcattttg     4980

tttagaatta caaaatagtt tttaaatatt gtctgagaaa agccaaagtt aatgcaacct     5040

agtggaaact gtaagaccat ttgagtattg tttgttttat tgatgcattt ggattttgtt     5100

gtttgatgga atttgagcca aaaaaaaaat acgcaggctt tcctatttct acaactgatt     5160

gtacttatgc attttgtacc agtggaactt tttatactgg agattaaaaa aaaaatggaa     5220

atttttgtgg cttgctctgg tgggcccctg acaatgactg atttcaagtt tgatttcggg     5280

ttgattgatt gattgattga tagaaagaaa gttgcttttc ttttgagaat taaaaacttt     5340

ggcttgattt cttttttccc tttgcttata tctagcatta gaattttgtc ttaaaataac     5400

agcggtaagt ttcacttttt attctgtatt gtgcagttac acaataaggt aattagattt     5460

agaagtactc agtcacttta agtggataaa tgtattagtt aaaactttag ggtttgcttt     5520

tttgctgttt agatcaaagt tttttctgat tcttctgtcc tcattgtgaa cataaccgtg     5580

tagttgaaac agtcaaactt atttttgtaa tgtatgttat tgtgtgatgc agttttttgc     5640

ttctgtctcc aatattaaac cattttccta atacttgttt ctctctctgc gtgttgtatt     5700

gttggtagtc attatatgtt ggtgatacat ctgcacacct cactgtttca cgtatctgtt     5760

tttttctcta tgttgtgtaa aaagatacag tcgattccac ttaagtgaat atctgatttg     5820

gggaagagga aactgcacag cagccacctt tgatttatgt acaaccgccc acttgaactc     5880

ctgcttccaa gatttataca cttttttcct acagttcacc tcagtaactg cctttggggt     5940

tggatttgcc aaggtgtttt acggtctttt gaccacacag gttaatttcc ccttctctcc     6000

cctccctcat gagtctatcc acgcagttct taacatacat tccaaactgc tgcggggttt     6060

cctctccaca cccacgaggc caaacccgca tcattacagt ccaactcttc ttagacacta     6120

atcactttct aaaagaagtg agttctccag ggaagaaaaa tcaacttagc cagtgaaaag     6180

ggttaaactt aagtctatta tttgttgccc tcaatcaaaa gatatgtata gaaaagtcat     6240

ttaaattatt tatttctaca agctaattga atccaggagc agctttaatt attaacacta     6300

acggaagaga aaagaagtat ttccaagggc tcaaatggaa gctgtactca gtccggtgga     6360

ggcaggggga ggtaaagttt ctcacactca agtcgtcttc atagtttact gtccttttcc     6420

aaacaaaagc taataacgcc atacgcatcc acacactccc tcctggatga acctaagtct     6480

cgtccccact gtcaccccaa ggccagttat caaaaactgt tccttctctg ccctcaaaga     6540

ctgaagccgc aggccctgtt ctgcctctgc tcaggaatct gattgctctt aaagtgctct     6600

tacaagattc cgtcgatgtt tgctccctct gtcttatctc tccttccagt attttcagac     6660

gcacaagctc tgactcaggc cacccagcac ctggcagcct tcctctgcgt gccagtgaaa     6720

tctctcccag taggtgctca ggctcttcac cctctcgttg cagcagcccc tctggcccga     6780

gattgtattt tctagtctgc tcaagaacag aggggcctgg cgaggtggag gaagggaggc     6840

tccctccccg gggctggccg cctcagtgat ggtgatgcca ccagctccag cctgcacgga     6900

tggagctcac ttcctaccat cacttctgct ttcagtctcc tcatagcctt cggcagtctc     6960

ctctgaaaac acactgccta cgttagtggg aaaggatggc taagggtgtg atttcttttt     7020

attagggagg tgggaggggg atgttgggag gcatgggggg tgattaaatt atcatttcca     7080

aggtgcaagt gtttattttt caaatctata agtacatagt tccaccattt tggcacaaga     7140

caaaatactc atgctaagca aaggaagaga aagacaaagc cagtttttgt tgcttttcta     7200

aagcaacaaa taattctcca aagaagggga tgaaaatgct agttccttta agcacttact     7260

gactgtaaag ttggtccctg cttaaattca tacccatagt tttgagtcgg tatgacacca     7320

ctgcagtgtg agcaaggtga atccgtgtgc catgcatgga ccaccttggg ataccgcagc     7380

accatcaaca tccgccttgc tgatggaagc cacacacgct gcccagccca cagcagtcgc     7440

acgcagccga tgggctcgga ctcttagctg gcaggctagg acacacagtg aacattaatg     7500

tactgtgaat cgttcctgat aagtgaataa aacattgtga ccaaacaatc agcttattca     7560

cttatcagga atcgactgtt ctgctaattt gctgttgttg tttttcatct ctgttgtagt     7620

tcactatttt tgctgtgttc tgttttctcc tctcatgctt gggcaaatca ctgggaatat     7680

tatcttcatg tgaccatgaa acgtttctat tgagtgaaaa tgatatctta acaaaatcta     7740

tgcacttgct atcaggaaca caatactgga tgtgtcttat atatattgaa ctatatagta     7800

ctcgatttct taaataaagc ttaagaaagg actctgttgt gtgtaaagtt aatgtgatta     7860

tttttcaaag cagtgtttct aaggggtatt tttgttcttt taagtcttga gtgatacagg     7920

atatttttca ttaaaattat atcactggct ttatgactta atattcaata aattgacttt     7980

gg                                                                    7982


<210> 3508
<211> 611
<212> DNA
<213> Homo sapiens

<400> 3508
agagttggcc tggagagtga gcggtggagg gagtggaaca aggcttcgtc aagagtcccc       60

aggagtccag gggcgccccc gagacgggtt gacgatgtgt cacactgtgt aagggaatcg      120

catggagatg ggcattccga actgttaatg gggacatggg actccagttg tctctgatca      180

cttgtgtgga ttttcctggc gtagaacgac agaagccgct agtaagtcgc caagacctac      240

agcaggaatt ctgcaccaaa gggcataaaa tcttgttatt ttaatttgca tctgggagaa      300

tgtctgagca aggagacctg aatcaggcaa tagcagagga aggagggact gagcaggaga      360

cggccactcc agagaacggc attgttaaat cagaaagtct ggatgaagag gagaaactgg      420

aactgcagag gcggctggag gctcagaatc aagaaagaag aaaatccaag tcaggagcag      480

gaaaaggtaa actgactcgc agccttgctg tctgtgagga atcttctgcc agaccaggag      540

gtgaaagtct tcaggatcag gaatcaattc atttacagct ttccagtttt tccagcctgc      600

aagaggagga t                                                           611


<210> 3509
<211> 2571
<212> DNA
<213> Homo sapiens

<400> 3509
agtagcgggc cgtcggttgg gcgcagacag gccgcagaag atggagagat ggagccaccc       60

caagagacaa ataggccttt cagcacactt gataaccgca gcgggcaggt ccaagtcctg      120

tccgccaccc cgctattgca gaggaatccc tacagcagcc cggatatcat gcacattaaa      180

gggtcggagg cttcttcggt cccttacgcc ctgaaccagg gcacgacggc cctgcctaag      240

aacaagaacc aggagggcac cgggcaccgg ctgctgaaca tgctgagaaa aactcttaaa      300

gagtctgata gtgaagaact ggaaataaca caggagacgc caaatttggt gccatttggg      360

gatgtggttg gctgcctggg cattcatata aagaactgca gacattttat gcctaagatc      420

agtttacaac attatgctaa tttattcatt cgcatctcta taaacaaagc tgtgaaatgt      480

acaaaaatgt gtagcttgct atccaaaaac gatgagaaga acactgtaat taagttcgat      540

gaagtgaagt atttttctgt acaggttccc agacgttatg atgataagcg gaataatatt      600

ttattggaac tcatacaata tgacaataga gaaaaacgtg ctttcttgtt agggagtgtt      660

cagatacatc tttatgaggt aattcagaaa gggtgcttca ttgaagaggt ccaagtgttg      720

catggaaaca tatttgtctg caggctggag gtggaattta tgttctccta tggaaacttt      780

ggttatggat tttcacatca gttaaaacct cttcagaaaa ttactgagcc atccatgttt      840

atgaatcttg caccacctcc agaaagaaca gatcccgtga caaaagttat tacaccacag      900

acagtagaat atccagcatt cttatcccca gacctgaatg ttactgttgg gactccagct      960

gtgcaatcct ccaaccagcc atctgtagtg cgacttgaaa aacttcagca acaaccccgg     1020

gaaaggctgg aaaagatgaa aaaagaatat agaaatctga atacatggat agataaagct     1080

aactatttag aaagcattct aatgccaaaa ttggaacata aggattctga ggaaactaat     1140

atagatgagg catctgaaaa cacgaaaagt aatcatcctg aagaggagct tgaaaatatt     1200

gtaggagtag atatccctct tgtaaatgag gaagctgaaa ctactgcaaa tgagttactg     1260

gataatgatt ctgagaaagg cctgactata ccaactttga accaatcgga ccaagataat     1320

tcaactgctg atgcttctaa aaatgatgaa tcaacacctt cacccacaga agtgcactca     1380

ttgtgcacta tttctaacca ggaaacaata aaagcaggca gaataccacc tttaggtgaa     1440

cgtcaatcag aaagcatgcc agacagaaaa atgaaaaatg tattttttcc attagaagta     1500

aaattaaaag ataactatcc aagcatttta aaagcagact catctctatc agaggtaaat     1560

ttgaggagta tctgtataaa tccaaagagc aggaacttag attcatctcc aacagaaatt     1620

agctggcaaa acaacaatct aaacttagct gaaagggaga acacaggctt agtttccacc     1680

agattaaaaa ttaaaaggta gctttcaaag ccaagaccca aaagaaggcc ttgagctcaa     1740

ggtgtctgcc cttatattag aagtataaga ctagggagac aaaataatct attttaaaaa     1800

attaaataca aataaatcga aaatgcattc aaatgtctcc aagtggaaat gtgtctaagt     1860

atattaaata ttcctgcttt acttatatca atcaagaaat gaggataaaa aactttcaag     1920

aaaagcaaag tgatttgaga tgccagtaat acaaattaat ctcttgggtt agtaattcag     1980

ctgaaagtgt aacgacaata acaaaatgta aattcaaagg aaatttaaaa gcctgaggag     2040

ttatttcagt ggaaattctt aataaaacta ttatattata ggaaataaca tgttctcctt     2100

attacaaata attttatagt ttaaaatgag aataagagtg tgaatttaaa ggtacaccaa     2160

ataatagact ttctcaaaat gacagccatt ctacttatat ctttatatct tattggaata     2220

actattacag gtagttcatc aaatggtata aaaagatata taggtcagaa gataaagaat     2280

ttgagttcta agtgagattc tgcttctaaa tactagcttg ggcatctaag tctctagacc     2340

tatttttctc attatttgaa tggtagatca gactaggtca tttctaaatt ctctcccaaa     2400

tttcaaaaga cataatttta actgggaatt actctcagtt acctatgtca aataacattc     2460

ttgttttttc tgaatgtgaa agtaatgcac agtcacagaa aatttagaaa atggagagaa     2520

atgtaaaaga aaaaataaaa gcagttataa ttctactgct agatttaaca a              2571


<210> 3510
<211> 587
<212> DNA
<213> Homo sapiens

<400> 3510
gggaatttcc ttgtgcctcc attcccggga ggggggagcg gcgttggagg ccaccgtttc       60

cagatgagga aactgaggcc ttggactaga acagaggtct cctgactcag tccaggactc      120

tttctattac atcatgcggc ctgatatttg tctttatgga actcagcaac atcacataca      180

ggggttatat cctgtgttgt gacctcatgg tttaagtggg aataaagatg agtataagca      240

gtgatgaggt caacttcttg gtatatagat acttgcaaga gtcaggattt tctcattcag      300

catttacctt tggtatagaa agccatatca gtcagtccaa tataaatggt gccctcgtcc      360

cacccgctgc attgatttct atcatccaga aaggtctaca gtatgtagaa gcagaagtta      420

gtattaatga ggatggtacc ttgtttgatg gtcgaccaat agagtctctg tccctgatag      480

atgccgtaat gcctgatgta gtacaaacaa gacaacaagc ttatagagat aagcttgcac      540

agcaacaggc agcagctgct gcagctgccg cagctgcagc cagccaa                    587


<210> 3511
<211> 567
<212> DNA
<213> Homo sapiens

<400> 3511
gtaaaaggcc actgactcct acttcctctg tatagagcaa ctgttgaact cagctgcctg       60

tagagcgaga ataggacaga ctcgtatacc attctgatct gggtgcattt cttcagaagg      120

tacgctgtcc tcacgggaaa ccgcccgcca ctgcctgggt ttggggctga tgaggccagg      180

aagaaactta atgcgtgcac tctaacaaaa agatttccca ggcgtgattc tcagtcacca      240

gactcagcaa aaggttttag aagcgttcga ccaaacctac aagataaaag atcaccaact      300

cagagccaga taacagtgaa tggaaactca ggaggtgccg tgagtcccat gagttactat      360

cagaggccgt tttccccctc ggcatattct ctcccagcct cactcaactc cagcattgtc      420

atgcagcacg gcacatccct cgattccaca gacacatatc cccagcatgc gcagtctctg      480

gatggcacca ccagcagctc tatccccctg taccgatcct cagaggaaga gaagagagtg      540

acagtcatca aagccccgca ttaccca                                          567


<210> 3512
<211> 958
<212> DNA
<213> Homo sapiens

<400> 3512
gcggcggcgg cagcggcagc ggcagcggcg ctgagttttg tctcccgggc cgtctgggcg       60

cgcgcgggtg tcccaggtac cccgccgcct ccctccttcc cgcaggactc gtccctcctg      120

gccctgggcc ccaacggtgc ccgcctgccc ggcggtcggt cagcgcacag ggcacggctt      180

cctctgcttc tcccggacca cttagtctca acccgggtgt gtttgcacta ctagagaatg      240

aaatatgact gaggactctc agagaaactt tcgttcagta tattatgaga aagtggggtt      300

tcgtggagtt gaagaaaaga aatcattaga aattctccta aaagatgacc gtctgggaat      360

cttgcctcca caccacgagt cccatgccaa ggtgatgatg tatcgtaagg agcagtactt      420

ggatgtcctt catgccctga aagtcgttcg ctttgttagt gatgccacac ctcaggctga      480

agtctatctc cgcatgtatc agctggagtc tgggaagtta cctcgaagtc cctcttttcc      540

actggagcca gatgatgaag tgtttcttgc catagctaaa gccatggagg aaatggtgga      600

agatagtgtc gactgttact ggatcacccg acgctttgtg aaccaattaa ataccaagta      660

ccgggattcc ttgccccagt tgccaaaagc gtttgaacaa tacttgaatc tggaagatgg      720

cagactgctg actcatctga ggatgtgttc cgcggcgccc aaacttcctt atgatctctg      780

gttcaagagg tgctttgcgg gatgtttgcc tgaatccagt ttacagaggg tttgggataa      840

agttgtgagt ggatcctgta agatcctagt ttttgtagct gtcgaaattt tattaacctt      900

taaaataaaa gttatggcac tgaacagtgc agagaagata acaaagtttc tggaaaat        958


<210> 3513
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 3513
gagtcaggaa tggagagaag ggtaatggtg ttacctctta ttgtggaaac ctgttgagat       60

cacagagaat atactgacgg cataaaaggg cagaaccata gcagggtgcg cgctgctgta      120

gttgccttcc atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg      180

aacggagacc tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg      240

aagaggaggt gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact      300

gtggccacgt cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc      360

ccgtctgccc actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac      420

tggccagcct ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag      480

aggtgacccg ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact      540

actactgtga ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca      600

ggccccacac ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga      660

accacctgag taccctaagg agagacagag acaaaattca gggcttccag gcaaagggag      720

aagctgatat cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg      780

agtttgagca gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg      840

cgaagctgga gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg      900

agcttgcccg gctggccctg gtcatctccg aactggaggg caaggcgcag cagccagctg      960

cagagctcat gcaggacacg agagacttcc taaacaggta tccacggaag aagttctggg     1020

ttgggaaacc cattgctcga gtggttaaaa aaaagaccgg agaattctca gataaactcc     1080

tctctctgca acgaggcctg agggaattcc aggggaagct gctgagagac ttggaatata     1140

agacagtgag cgtcaccctg gacccacagt cggccagtgg gtacctgcag ctgtcagagg     1200

actggaagtg cgtgacctac accagcctgt acaagagtgc ctacctgcac ccccagcagt     1260

ttgactgtga gcctggggtg ctgggcagca agggcttcac ctggggcaag gtctactggg     1320

aagtggaagt ggagagggag ggctggtctg aggatgaaga agagggggat gaggaggaag     1380

agggagaaga ggaggaggag gaagaggagg ccggctatgg ggatggatat gacgactggg     1440

aaacggacga agatgaggaa tcgttgggcg atgaagagga agaagaggag gaggaagagg     1500

aggaagttct ggaaagctgc atggtggggg tggctagaga ctctgtgaag aggaagggag     1560

acctctccct gcggccagag gatggcgtgt gggcgctgcg cctctcctcc tccggcatct     1620

gggccaacac cagccccgag gctgagcttt tcccagcact gcggccccgg agagtgggca     1680

tcgccctgga ttatgaaggg ggcaccgtga ctttcaccaa cgcagagtca caggaactca     1740

tctacacctt cactgccacc ttcacccggc gcctggtccc cttcctgtgg ctcaagtggc     1800

caggaacacg cctcctgcta agaccctgag ccctgacatc tgcccccagc cccaaccctc     1860

agatgcttca cttctttgga attccaggac tctcaatggg gggacgggat gcctggccta     1920

agcacctgga gcaggggacc ccatatccac tggtagccac ctccccattg ctgtggcccc     1980

ctgaaatctc actcagtgct gttgctccat ctactgccct aatggggctc ttttcccacc     2040

tcctgctggt ttcccgaggg aacttctgac cctggagtcc atgagggctc ctttcctttt     2100

tgaccacgac cttggcccca gctctgcact ctctggaata agggcccgat gcagcatttt     2160

cttgcccagt gtggcaagac ctcagaaaaa ccagtcaatt acgcctaaga tcattttgct     2220

gtccttaaac cccccaggtt ccttcttgca caaatccact ctgctgccca ccttctctgg     2280

cattttaaac agacctaccc caccccaact cagagttaag catacatggc aatgctgaaa     2340

ataaacaaaa tccactgagg cttcccaggc catttaaagc ctggagtacc agcgcatatc     2400

atctcatggg gtccagagtg gagtccaggc ttctctgaaa ccagggctga gcatatttcc     2460

atagccaagg aggtgggact ccctggagct atctgtggtc ttagggaagg atccagacat     2520

acacggcttt ggggtacaag ctgtgatcac tgatcaataa attatctcta gattggtcct     2580

tgtgagggga gttttaagaa tccagaacat cttgctcttg atcagcacat ccaaaaacac     2640

caagacaaac atccagtgga gcagaacctc tcctgcctcg ggagttctga ccgggttccc     2700

cagcagggtg ttaagcctct gtctctggcc ctaccagcat ccaggttcca ctttcctagg     2760

agagagtgga gatgggaaga cagggaaagg aaggcagcag gaggccacaa gcccaccagg     2820

tcttcatgtc aagagaggga gtaacatgtc ttctcattgc ccacggaccc aacctctgtc     2880

caggtgcccc tcatcatcac agtttaacac aagctcccct gctccagcca aattgatctc     2940

ccagtcttgt ccttacccat tccaagtgct ctgccagccc ctgttcatcc aagttttaag     3000

tcctccaccc tgttctaaga gactgttcca acggctctgg gcctcagtgg tcacttgacc     3060

accattgtct cagagctgcc cactttgtgt gtgtcacatg ctgcctgagt cacatgtaca     3120

tcttatttct gcctctagtt ttgtaagctc ctggagggcg gataacatct tatactactc     3180

ttgtattctc atggcaccta gtgcagtgct gggcacagag taggtgctca ataaagactt     3240

gttgaatgaa                                                            3250


<210> 3514
<211> 822
<212> DNA
<213> Homo sapiens

<400> 3514
cctctctcca tttctctgaa aatgaactac acagtttggg ggtgagttgg caggggctgc       60

ttcctgagca atactgaaca ctgcgcagct tgcagaggtc tcctggcagc cctcattagg      120

aattctgtct ggccccgatc agaatactgg agacgagacc acgagattga tgagtttgcc      180

ttgggagtcg gtaagaaggt gaagccaggg gcgaacatgg gtcagaaggt cactggaggg      240

atcaagactg tggacatgag ggaccccacg tacaggcccc tgaagcagga gctccagggt      300

ctggattact gcaagcccac ccggctggat ctgctactgg acatgccccc tgtgtcctat      360

gatgtccagc tgctgcattc atggaacaac aacgaccgat cgctcaatgt ctttgtgaag      420

gaggacgaca agctcatctt tcaccggcat ccggtggccc agagcacgga cgctatcagg      480

ggcaaagtcg ggtatacccg tgggctgcac gtgtggcaga tcacgtgggc catgagacag      540

cggggcacac acgccgtggt gggggtggcg acggcagacg cccccctgca ctctgtcggg      600

tacacaaccc tcgtggggaa taaccacgag tcctggggct gggacttggg gcgcaaccgg      660

ctctaccacg atggcaagaa ccagccaagc aaaacatacc cagcctttct ggaaccagat      720

gagacattca ttgtccctga ctccttcctg gtagccctgg acatggacga cgggactctg      780

agcttcattg tggatggaca gtacatggga gtggcttttc gg                         822


<210> 3515
<211> 427
<212> DNA
<213> Homo sapiens

<400> 3515
aatttgccca tctgcatggc aaagacccac ctttctctat ctcaccaacc tgacaaaaaa       60

ggtgtgccaa gggacttcat cttacctatc agtgacgtcc gggccagcat aggcgctggg      120

ttcatttacc ctttggtcgg aacgggaggc agagaagctc ccctctggct ctagttggag      180

aatcccaacc caagcaagtc catccttaaa caataaacat ctccagcatt gctggctttg      240

gaagacccca tggtgagatg ctggagcttt tttccgctcc agatttcgct tctaaatatt      300

tacttttact ttccatgttc acttataggc cagggttttt ttttcctacc attgaattat      360

ttcgtcatgt tctatttaat tattgcttta attggcattg gtgaccacaa ataataataa      420

atactat                                                                427


<210> 3516
<211> 578
<212> DNA
<213> Homo sapiens

<400> 3516
agaaagaaaa ggtatcagta cagaaaagaa gagtcagaaa ataccgtgca aaggcacatt       60

cagaacgtaa ccaggatagc tggagccagg attcaaggag agagggtgtc ttttatgaat      120

aatcaaaagc agcaaaagcc aacgctatca ggccagcgtt ttaaaactag aaaaagagat      180

gaaaaagaga ggtttgaccc tactcagttt caagactgta ttattcaagg cttaactgaa      240

accggtactg atttggaagc agtagctaag tttcttgatg cttctggagc aaaacttgat      300

taccgtcgat atgcagaaac actctttgac attctggtgg ctggtggaat gctggcccca      360

ggtggtacac tggcagatga catgatgcgt acagatgtct gcgtgtttgc agcccaagaa      420

gatctagaga ccatgcaagc atttgctcag gtttttaaca agttaatcag gcgctacaaa      480

tacctggaga aaggttttga agatgaagta aaaaagctgc tgctgttctt gaagggtttt      540

tcagagtcgg agaggaacaa gctagctatg ttgactgg                              578


<210> 3517
<211> 583
<212> DNA
<213> Homo sapiens

<400> 3517
ttttgatgac cagcgcagga tgtcattgca tctacatgga gcagattgtg atcctaaaac       60

acagaatgaa atgaatatat gtgaagaaga atttgtagag tataaaaaca gggatgccat      120

ttcggcattg atgcctttgt tctctgagga agaaagcagt gatggaagca agcacaataa      180

tggtttacca gatcatatct cagctcaact acagaacacc tacactctga aagcctttac      240

tgttggatct aaatgtgttg tgtggtcaag tctaagaaac acatggtcta aatgtgagat      300

tttagaaaca gctgaagaag gaacaagggt tttgaacctt tcaaatggta tggaggagat      360

agtgaaccct gagaatgtct ggaatggcat acccaaattg gataagagtc cacctgaggc      420

tgtatcccaa agagtaggga aagatcttta cttcatgtca gtgggtgata ccactattaa      480

agaaaagggg tttggaggtg atggagattt aaccgtggat ctatagctgt ggccaatcag      540

tcagaagctg cccttgaaca agtggcatct tacgcagacc aac                        583


<210> 3518
<211> 3745
<212> DNA
<213> Homo sapiens

<400> 3518
cctgagaagc cagccaggct gcggctgttt gtggcaggag gcccccaccc acagcactgg       60

accaagcgtc gagggcgagg cccccagcag tgagactggc acatccctgg acagcccctc      120

agcctacccc cagggcccct tggtgcccgg ttccagcctg agcccggatc actacgagca      180

cacgtcagtg ggagcctatg ggctgtactc ggggccgccg gggcaacagc agcgcacgcg      240

gaggcccaag ctgcagcact cgacctccat cctgcgcaag caggctgagg aggaggccat      300

caagcgctca cgctcactct ccgagagcta tgagctctcc tcggacctgc aggacaagca      360

ggtggagatg ctagaacgaa agtatggggg gcgcctggta acccgccatg cggcccgcac      420

catccagacg gcgtttcgcc agtaccagat gaacaagaac ttcgagcgct tgcgcagctc      480

catgtcagag aaccgcatgt cacgccggat tgtgctgtcc aacatgagga tgcagttctc      540

ctttgagggg cctgagaaag tgcacagctc ctacttcgag gggaagcagg tctcagtgac      600

taacgacggc tcccagctgg gagccctggt gtcccctgag tgtggtgacc tcagcgagcc      660

caccaccctc aagtctccgg ccccctccag tgactttgcg gacgccatca ccgagctgga      720

ggacgccttc tctaggcaag tgaaatcact ggccgagtcc atcgacgatg ccctcaactg      780

ccgcagcctg cacactgagg aggcaccggc cctggatgcg gcgcgggccc gggacaccga      840

accccagaca gccctgcacg gcatggacca ccgcaaactg gacgagatga cggcctcgta      900

cagtgatgtc accctgtaca tcgatgagga ggagctgtcg ccccctctgc ccctctcgca      960

ggcaggggac cggccgtcca gcaccgagtc ggacctgcgg ctacgggctg ggggcgcagc     1020

cccagactac tgggccctgg cccacaaaga ggacaaggct gacacggaca cgagctgccg     1080

gagcacgccg tcgctggagc ggcaggagca gcggctgcgg gtggagcatc tgccgctgct     1140

caccatcgag ccacccagcg acagctctgt ggaccttagt gaccgctcgg agcgggggtc     1200

actcaagagg cagagtgctt acgagcgcag ccttggcggg cagcagggca gtcccaagca     1260

tggtccccac agcggcgccc ccaagagcct cccccgggag gagcctgagt tgcggccccg     1320

gccccccagg cccctggaca gccacttggc catcaatggc tcagccaacc ggcagagcaa     1380

gtctgagtcg gactactcag acggtgacaa tgacagcatc aacagcacgt ccaactccaa     1440

cgataccatc aactgcagct ccgagtcatc gtcccgtgac agcctgcggg agcagacgct     1500

cagcaagcag acctaccaca aggaggcccg caacagctgg gactcgcctg cctttagcaa     1560

cgatgtcatc cgcaagaggc actaccgcat cggcctgaac ctcttcaaca agaagcctga     1620

gaagggagtc cagtacctca tcgagcgtgg ctttgtgccc gacacgcccg tcggggtggc     1680

ccacttcctg ctgcagcgca agggcctcag ccggcagatg atcggcgagt tcctgggcaa     1740

ccggcagaag cagttcaacc gtgacgtgct cgactgcgtc gtggacgaga tggacttctc     1800

taccatggag ctggatgagg ccctcaggaa attccaggcg cacatccgtg tccaagggga     1860

ggctcagaaa gtggagcggc tcatagaggc gttcagccag cgctactgca tctgcaaccc     1920

tggggtggtg cggcaattcc ggaacccaga caccattttc atcctggcct tcgccatcat     1980

cctgctgaac accgacatgt acagccccaa tgtcaagccc gagcggaaaa tgaagctaga     2040

ggacttcatc aagaacctcc gaggtgtgga cgatggtgag gacattcccc gtgagatgct     2100

gatggggatc tatgaacgga tccgtaagcg agagctaaag accaatgagg accatgtgtc     2160

ccaggtgcag aaggtggaga agctcattgt ggggaaaaag ccgatcggat ccctgcatcc     2220

cgggctcggc tgtgtgctct ctctgcccca ccgtcggttg gtctgctact gccggctctt     2280

tgaggttcca gacccaaaca agccccagaa actcggacta caccagcgag aaatcttcct     2340

gttcaacgac ctcctggtgg tcaccaagat cttccagaag aagaagaact cggtgacgta     2400

cagcttccga cagtccttct ccttgtacgg catgcaggtc ctgctcttcg agaaccagta     2460

ctaccccaat ggcatccggc tcacctcgtc tgtccccgga gcagatatca aagtgttaat     2520

aaacttcaac gcccccaacc ctcaagaccg gaagaaattc accgatgacc tgcgggagtc     2580

cattgcggaa gtccaagaga tggagaagca caggatagag tcggagctcg agaagcagaa     2640

aggcgtcgtg cggcccagca tgtcccagtg ctctagcctc aaaaaggagt cgggcaacgg     2700

aacactgagc cgggcctgcc tggacgacag ctatgccagc ggtgagggcc tcaagcgcag     2760

cgccctcagc agctccctgc gggacctctc ggaagccggg gtccatcatt agcagtcctc     2820

acatgcgccg gagagctaca tcaacacgag agtgtccatc tcgcccacac cagactatgc     2880

ccaactcatc ttccctcctg ggctccttat tcgggagcaa gagagggaag ccccctcccc     2940

aggcccacct gccctcagcc ccagccctgg ccaccccccc acccaccggt ggtcctgcct     3000

cacttgcagc actctgtggc tggccaccac ctggggcccc cagaggggct gccgcaggcc     3060

gccatgcacg ggcatcacac ccagtactgc cacatgcaga accctccccc gtaccaccat     3120

caccaccacc accacccacc ccagcacatc cagcacgcac accagtacca ccacggcccc     3180

catgggggcc acccagccta cggggcccat gcccacggcc acccgccgct gccctcggcc     3240

cacgtggggc acacagtgca ccaccatggg cagccccctg ccccgccgcc ccccaccagc     3300

agcaaggcca aacccagcgg catcagcaca attgtgtaga cagcctgggt aggggtccca     3360

ggctccctga aacacctgca caccacacag ggcacgcccg ggggtcgcca gccgcacacc     3420

aaacccgggg cacttctgtt gccatctctc ccctctgccc ctcacggccc aaccggagcc     3480

ccaggagccc acagggctgg tgttgtgtgg aacaaaggcc cagatttcat ttcttgttgg     3540

caccctgggc tctgctcacc tcagtctgag ggatgggtgg gcctcagaca ccatcagcct     3600

tgaaacggtg agccagccaa gtagtgttga actgcctccc ccactccagc tctcagctcc     3660

ctgtgcccta atgtacatgc atatgaaaac ccaacctaga aaacgaagaa atgagataca     3720

aaaacagaca aaacaaaccc caaaa                                           3745


<210> 3519
<211> 1403
<212> DNA
<213> Homo sapiens

<400> 3519
cagcttctgg caggatatga gctgatgcct gccccgattc tacagacacc atgagattta       60

atccagagac tgacttcact atagaaccca cagttgtatc aatggttggg gaaagatagt      120

ggcaacaggc aaaggagaaa cagctctgac atacaaagaa aatgagtatg ctaaagccaa      180

gtgggcttaa ggcccccacc aagatcctga agcctggaag cacagctctg aagacaccta      240

cggctgttgt agctccagta gaaaaaacca tatccagtga aaaagcatca agcactccat      300

catctgagac tcaggaggaa tttgtggatg actttcgagt tggggagcga gtttgggtga      360

atggaaataa gcctggattt atccagtttc ttggagaaac ccagtttgca ccaggccagt      420

gggctggaat tgttttagat gaacccatag gcaagaacga tggttcggtg gcaggagttc      480

ggtatttcca gtgtgaacct ttaaagggca tatttacccg accttcaaag ttaacaagga      540

aggtgcaagc agaagatgaa gctaatggcc tgcagacaac gcccgcctcc cgagctactt      600

caccgctgtg cacttctacg gccagcatgg tgtcttcctc cccctccacc ccttcaaaca      660

tccctcagaa accatcacag ccagcagcaa aggaaccttc agctacgcct ccgatcagca      720

accttacaaa aactgccagt gaatctatct ccaacctttc agaggctggc tcaatcaaga      780

aaggagaaag agagctcaaa atcggagaca gagtattggt tggtggcact aaggctggtg      840

tagtccggtt tcttggggag accgactttg ccaaggggga gtggtgtggc gtggagttag      900

atgagccact tgggaagaat gatggcgctg ttgctggaac aaggtatttt cagtgtcaac      960

ccaaatatgg cttgttcgct cctgtccaca aagttaccaa gattggcttc ccttccacta     1020

caccagccaa agccaaggcc aacgcagtga ggcgagtgat ggcgaccacg tccgccagcc     1080

tgaagcgcag cccttctgcc tcttccctca gctccatgag ctcagtggcc tcctctgtga     1140

gcagcaggcc cagtcggaca ggactacatg tcctggaatt ggaagccaaa atggaccagc     1200

tgcgaacaat ggtggaagct gctgacaggg agaaggtgga gcttctcaac cagcttgaag     1260

aggagaaaag gaaggttgag gaccttcagt tccgggttga agaagaatca attaccaaag     1320

gtgatcttga gcaaaagagc cagatttctg aagatcctga gaatgtggct acagtttcag     1380

aaaagtcacg tataatggaa ctg                                             1403


<210> 3520
<211> 1300
<212> DNA
<213> Homo sapiens

<400> 3520
gtggcgctgg cggttgctgt cagctgattc ccggggttgg tggcagcggc ggtagcagca       60

atggactttc tcctggggaa cccgttcagc tctccagtgg gacagcgcat cgagaaagcc      120

acagatggct ccctgcagag cgaggactgg gccctcaaca tggagatctg cgacatcatc      180

aacgagacgg aggaaggtcc caaagatgcc ctccgagcag taaagaagag aatcgtgggg      240

aataagaact tccacgaggt gatgctggct ctcacagtct tagaaacctg tgtcaagaac      300

tgcgggcacc gcttccacgt gctggtggcc agccaggact tcgtggagag tgtgctggtg      360

aggaccatcc tgcccaagaa caacccaccc accatcgtgc atgacaaagt gctcaacctc      420

atccagtcct gggctgacgc gttccgcagc tcgcccgatc tgacaggtgt ggtcaccatc      480

tatgaggacc tgcggaggaa aggcctggag ttccccatga ctgacctgga catgctgtca      540

cccatccaca cacccagagg accgtgttca actcagagac acaatcagga caggattctg      600

tgggcactga ctccagccag caagaggact ctggccagca tgctgcccct ctgcccgccc      660

cgcccatact ctccggtgac acgcccatag caccaacccc ggaacagatt gggaagctgc      720

gcagtgagct ggagatggtg agtgggaacg tgagggtgat gtcggagatg ctgacggagc      780

tggtgcccac ccaggccgag cccgcagacc tggagctgct gcaggagctc aaccgcacgt      840

gccgagccat gcagcagcgg gtcctgagtg ataccctgct ccgggcccat gccccaagga      900

gcccttcaga gcccacactg ccagtcgagg cctggctgga ggctggccac agtggaaatt      960

ctgccgagcc tcttgtccct tccctgctct gctgcatggg gccccatggc tttggctggc     1020

cactgagggt agggtgtgga ggtgtggagg ccccctgagg agctgcggcg gcccaggtac     1080

gaagctgcaa ctctgcgcgc agtgggcgag atctcatcag ccccaggctg caggtgaggc     1140

ttcaggggat gctggggccc cactgcccct ccgctgcctt gccctccatc cttcctctgt     1200

tccttctggc cgggcaccac agcactgggg ctcacctctt ggttgatcct cttgtactgg     1260

gagaggtgcc ttttgtatcc ccaattaaag gtagaaaacc                           1300


<210> 3521
<211> 489
<212> DNA
<213> Homo sapiens

<400> 3521
tatcaatatg gtaacatttt gatagattct ttggtattct tgtttgtgat attaagccat       60

attcacaaaa acttgtcttt tttttttttt tgagatggag tctcgctcta ttgcccaggc      120

tggagcgtaa tggcgcaatc tcggctcact gcaccctccg cctcctgggt tcaagcgatt      180

ctcctccttc agcttcctca gtagctggga ttacaggcac gcgccaccac acctggcatg      240

gcggacaccg acctgttcat ggaatgtgag gaggaggagt tggagccatg gcagaaaatc      300

agtgatgtca ttgaggactc tgtagttgaa gattataatt cagtggataa aactaccaca      360

gctggcaatc ctttggtcca gcaaggtgga cagccactca tcctgaccca gaatccagcc      420

ccaggtctgg gcacaatggt tactcaacca gtattgaggc ctgttcaggt catgcagaat      480

gccaatcat                                                              489


<210> 3522
<211> 659
<212> DNA
<213> Homo sapiens

<400> 3522
ggcggaagat ggcgacgccc ctcgggtggt cgaaggcggg gtcaggatct gtgtgtctcg       60

ctttagatca actgcgggac gtgattgagt ctcaggagga actaatccac cagctgagga      120

acgtgatggt tctccaggac gaaaattttg tcagtaaaga agagttccag gcagtggaga      180

agaagctggt ggaagagaaa gctgcccatg ccaaaaccaa ggtcctcctg gccaaggaag      240

aggagaagtt acagtttgcc ctcggagagg tagaggtgct atccaagcag ctggagaaag      300

agaagctggc ctttgaaaaa gcgctctcca gtgtcaagag caaagtcctt caggagtcca      360

gcaagaagga ccagctcatc accaagtgca atgagattga gtctcacatt ataaagcaag      420

aagatatact taatggcaaa gagaatgaga ttaaagagtt gcagcaagtt atcagccagc      480

agaaacagat cttcaggaat cacatgtctg acttccggat ccagaagcag caggagagct      540

acatggccca ggtgctggac cagaagcata agaaagcctc agggacacgt caggcccgca      600

gccaccagca tcccagggaa aaataaaatg gccgccgctt tcctgttctc tggctgtaa       659


<210> 3523
<211> 505
<212> DNA
<213> Homo sapiens

<400> 3523
cggacttgga gtcagagaga cctggctgcg aatcccggct ccgccacttt ctagcgctgt       60

gaccttggtt ttcaggtggc gaaactgact ggtctggtta gagcgcgtcc aagccaagcc      120

gcagtgctgt ttggattttt aaatttctcc ttctgagtga gaaaatagca atcgagatgg      180

aaccatccgc acaacagctc cagctggcag catcacttcc cgccaattta tccaacttct      240

gccaaggctc tgaaatgcca acaacgtcga ggcctgcact tgatgtcaag ggtggcacct      300

cacctgcgaa ggaggatgcc aaccaagaga tgagctccgt ggcctactcc aaccttgcgg      360

tgaaagatcg caaagcagtg gccattctgc actaccctgg ggtagcctca aatggaacca      420

aggccagtgg ggctcccact agttcctcgg gatctccaat aggctctcct acaaccaccc      480

ctcccactaa acccccatcc ttcaa                                            505


<210> 3524
<211> 1839
<212> DNA
<213> Homo sapiens

<400> 3524
ttgcgcctgc gcagtgcatc accgcaggcg ggcctcgcgg gtccgggagc gcggcggaga       60

cgatgcctga gatcagagtc acgcccttgg gggccggcca ggacgtgggc cgaagctgca      120

tcctggtctc cattgcgggc aagaatgtca tgctggactg tggaatgcac atgggcttca      180

atgacgaccg acgcttccct gacttctcct acatcaccca gaacggccgc ctaacagact      240

tcctggactg tgtgatcatt agccacttcc acctggacca ctgcggggca ctcccctact      300

tcagcgagat ggtgggctac gacgggccca tctacatgac tcaccccacc caggccatct      360

gccccatctt gctggaggac taccgcaaga tcgccgtaga caagaagggc gaggccaact      420

tcttcacctc ccagatgatc aaagactgca tgaagaaggt ggtggctgtc cacctccacc      480

agacggtcca gattaaagtg ggctcagagt ctgtggtcta cacgggtgat tataacatga      540

ccccagaccg acacttagga gctgcctgga ttgacaagtg ccgccccaac ctgctcatca      600

cagagtccac gtacgccacg accatccgtg actccaagcg ctgccgggag cgagacttcc      660

tgaagaaagt ccacgagacc gtggagcgtg gtgggaaggt gctgatacct gtgttcgcgc      720

tgggccgcgc ccaggagctc tgcatcctcc tggagacctt ctgggagcgc atgaacctga      780

aggtgcccat ctacttctcc acggggctga ccgagaaggc caaccactac tacaagctgt      840

tcatcccctg gaccaaccag aagatccgca agactttcgt gcagaggaac atgtttgagt      900

tcaagcacat caaggccttc gaccgggctt ttgctgacaa cccaggaccg atggttgtgt      960

ttgccacgcc aggaatgctg cacgctgggc agtccctgca gatcttccgg aaatgggccg     1020

gaaacgaaaa gaacatggtc atcatgcccg gctactgcgt gcagggcacc gtcggccaca     1080

agatcctcag cgggcagcgg aagctcgaga tggaggggcg gcaggtgctg gaggtcaaga     1140

tgcaggtgga gtacatgtca ttcagcgcac acgcggacgc caagggcatc atgcagctgg     1200

tgggccaggc agagccggag agcgtgctgc tggtgcatgg cgaggccaag aagatggagt     1260

tcctgaagca gaagatcgag caggagctcc gggtcaactg ctacatgccg gccaatggcg     1320

agacggtgac gctgcccaca agccccagca tccccgtagg catctcgctg gggctgctga     1380

agcgggagat ggcgcagggg ctgctccctg aggccaagaa gcctcggctc ctgcacggca     1440

ccctgatcat gaaggacagc aacttccggc tggtgtcctc agagcaagcc ctcaaagagc     1500

tgggtctggc tgagcaccag ctgcgcttca cctgccgcgt gcacctgcat gacacacgca     1560

aggagcagga gacggcattg cgcgtctaca gccacctcaa gagcgtcctg aaggaccact     1620

gtgtgcagca cctcccagac ggctctgtga ctgtggagtc cgtcctcctc caggccgccg     1680

ccccttctga ggacccaggc accaaggtgc tgctggtctc ctggacctac caggacgagg     1740

agctggggag cttcctcaca tctctgctga agaagggcct cccccaggcc cccagctgag     1800

gccggcaact cacccagccg ccacctctgc cctctccca                            1839


<210> 3525
<211> 676
<212> DNA
<213> Homo sapiens

<400> 3525
tgatgatgca tccctggaag acctgggagc caggtctggc tccttggact gtatcttccg       60

tgctccagtg ggagtacaga ctgagaggga gaagggggct gggtagagat gcagcccatg      120

tcgtttggct gggatcactc gcttcacaaa aggaaaagac ttcctcctgt gaagagatcc      180

ttagtatact acttgaagaa ccgggaagtc aggctacaga atgaaaccag ctactctcga      240

gtgttgcatg gttatgcagc acagcaactt cccagtctcc tgaaggagag agagtttcac      300

cttgggaccc ttaataaagt gtttgcatct cagtggttga atcataggca agtggtgtgt      360

ggcacaaaat gcaacacgct atttgtcgta gatgtccaga caagccagat caccaagatc      420

cccattctga aagaccggga gcctggaggt gtgacccagc agggctgtgg tatccatgcc      480

atcgagctga atccttctag aacactgcta gccactggag gagacaaccc caacagtctt      540

gccatctatc gactacctac gctggatcct gtgtgtgtag gagatgatgg acacaaggac      600

tggatctttt ccatcgcatg gatcagcgac actatggcag tgtctggctc acgtgatggt      660

tctatgggac tctggg                                                      676


<210> 3526
<211> 3232
<212> DNA
<213> Homo sapiens

<400> 3526
cttctctccc caccccaccc ccactactcc ctcacattga ccagtgtcct gggcctttaa       60

gagttggatg ggctggactg gagagagctc acacctctcc ccttcttact gcttccctcc      120

ggctataact tgccagtcac agcagccagc tgctgtagaa gaggggagga aacaagccag      180

tgcaagggga gcaaaagaga aaaggagcca ggctgggctt cctgatccca cagcatcgca      240

gagctcggga ggcacagctc acagacacag gaaacacagg actgctattc tgctctcctg      300

cccacggtga tctggtgcca gctggtggaa cagtgggtga tggcgtccct gctgcaagac      360

cagctgacca ctgatcagga cttgctgctg atgcaggaag gcatgccgat gcgcaaggtg      420

aggtccaaaa gctggaagaa gctaagatac ttcagacttc agaatgacgg catgacagtc      480

tggcatgcac ggcaggccag gggcagtgcc aagcccagct tctcaatctc tgatgtggag      540

acaatacgta atggccatga ttccgagttg ctgcgtagcc tggcagagga gctccccctg      600

gagcagggct tcaccattgt cttccatggc cgccgctcca acctggacct gatggccaac      660

agtgttgagg aggcccagat atggatgcga gggctccagc tgttggtgga tcttgtcacc      720

agcatggacc atcaggagcg cctggaccaa tggctgagcg attggtttca acgtggagac      780

aaaaatcagg atggtaagat gagtttccaa gaagttcagc ggttattgca cctaatgaat      840

gtggaaatgg accaagaata tgccttcagt ctttttcagg cagcagacac gtcccagtct      900

ggaaccctgg aaggagaaga attcgtacag ttctataagg cattgactaa acgtgctgag      960

gtgcaggaac tgtttgaaag tttttcagct gatgggcaga agctgactct gctggaattt     1020

ttggatttcc tccaagagga gcagaaggag agagactgca cctctgagct tgctctggaa     1080

ctcattgacc gctatgaacc ttcagacagt ggcaaactgc ggcatgtgct gagtatggat     1140

ggcttcctca gctacctctg ctctaaggat ggagacatct tcaacccagc ctgcctcccc     1200

atctatcagg atatgactca acccctgaac cactacttca tctgctcttc tcataacacc     1260

tacctagtgg gggaccagct ttgtggccag agcagcgtcg agggatatat acgggccctg     1320

aagcgggggt gccgctgcgt ggaggtggat gtatgggatg gacctagcgg ggaacctgtc     1380

gtttaccacg gacacaccct gacctcccgc atcctgttca aagatgtcgt ggccacagta     1440

gcacagtatg ccttccagac atcagactac ccagtcatct tgtccctgga gacccactgc     1500

agctgggagc agcagcagac catggcccgt catctgactg agatcctggg ggagcagctg     1560

ctgagcacca ccttggatgg ggtgctgccc actcagctgc cctcgcctga ggagcttcgg     1620

aggaagatcc tggtgaaggg gaagaagtta acacttgagg aagacctgga atatgaggaa     1680

gaggaagcag aacctgagtt ggaagagtca gaattggcgc tggagtccca gtttgagact     1740

gagcctgagc cccaggagca gaaccttcag aataaggaca aaaagaagaa atccaagccc     1800

atcttgtgtc cagccctctc ttccctggtt atctacttga agtctgtctc attccgcagc     1860

ttcacacatt caaaggagca ctaccacttc tacgagatat catctttctc tgaaaccaag     1920

gccaagcgcc tcatcaagga ggctggcaat gagtttgtgc agcacaatac ttggcagtta     1980

agccgtgtgt atcccagcgg cctgaggaca gactcttcca actacaaccc ccaggaactc     2040

tggaatgcag gctgccagat ggtggccatg aatatgcaga ctgcagggct tgaaatggac     2100

atctgtgatg ggcatttccg ccagaatggc ggctgtggct atgtgctgaa gccagacttc     2160

ctgcgtgata tccagagttc tttccaccct gagaagccca tcagcccttt caaagcccag     2220

actctcttaa tccaggtgat cagcggtcag caactcccca aagtggacaa gaccaaagag     2280

gggtccattg tggatccact ggtgaaagtg cagatctttg gcgttcgtct agacacagca     2340

cggcaggaga ccaactatgt ggagaacaat ggttttaatc catactgggg gcagacacta     2400

tgtttccggg tgctggtgcc tgaacttgcc atgctgcgtt ttgtggtaat ggattatgac     2460

tggaaatccc gaaatgactt tattggtcag tacaccctgc cttggacctg catgcaacaa     2520

ggttaccgcc acattcacct gctgtccaaa gatggcatca gcctccgccc agcttccatc     2580

tttgtgtata tctgcatcca ggaaggcctg gagggggatg agtcctgagg tgggcatttc     2640

acgggaaggg ttggtgtgct ggctttagac ggggagaaac atctggaagg atgctcgaga     2700

gaacaaatgg aggtggtgaa aatcaagctt tggattgtgc attcctaggc acaaaattac     2760

ctcattcttc ctaacaagca atctgggacc tgattttcca ccttttttct cttttcttcc     2820

cttcctttgt tttcataagc ctttggtatc tttcctgccc ttttcctttg tgtactctat     2880

actggagttc ccttcttcct cttgctgtag gctcaatccc ataccgacat ctacaactaa     2940

tctttcccat caactctgtg tgaaggcagg ttgcaactag aaattcagag gggcttggaa     3000

tagagaaacc taaagaagca tcatcccctc catccccaac ttcctcaaag cccaaagcca     3060

agggaaggat aaatcaaggc tcaaggcttc cccagcaaag attagggaaa gagacttgac     3120

cccaggactg tactacgact cttaagagaa cactgcacag cactcaaagt cccccactgg     3180

actgcttcct ccttagcccc actggtataa atacatctct ctccaatttg gc             3232


<210> 3527
<211> 1591
<212> DNA
<213> Homo sapiens

<400> 3527
agtgccaaga gcagcggttg ttggagtgta actgccatgc tcagccgcga tggctggggc       60

tgccgggcgc gtccaagatc gcgccctgcg gcggtttccc atcaccctgc ctgtgggcga      120

cttgagcaac ttgcatctta aggaagagaa aatcaaacca gataccaatg gtgctgttgt      180

caagaccaat gccaatgcag agaagacaga tgaagaagag aaagaggaca gagctgccca      240

gtccttactc aacaagctga tcagaagcaa ccttgttgat aacacaaacc aagtggaagt      300

cctgcagcgg gatccaaact cccctctgta ctcggtgaag tcttttgaag agcttcggct      360

cccacagaac ttaattgccc aatctcagtc tggtactggt aaaacagctg ccttcgtgct      420

ggccatgctt agccaagtag aacctgcaaa caaatacccc cagtgtctat gtctctcccc      480

aacgtatgag ctcgccctcc aaacaggaaa agtgattgaa caaatgggca aattttaccc      540

tgaactgaag ctagcttatg ctgttcgagg caataaattg gaaagaggcc agaagatcag      600

tgagcagatt gtcattggca cccctgggac tgtgctggac tggtgctcca agctcaagtt      660

cattgatccc aagaaaatca aggtgtttgt tctggatgag gctgatgtca tgatagccac      720

tcagggccac caagatcaga gcatccgcat ccagaggatg ctgcccagga actgccagat      780

gctgcttttc tccgccacct ttgaagactc tgtgtggaag tttgcccaga aagtggtccc      840

agacccaaac gttatcaaac tgaagcgtga ggaagagacc ctggacacca tcaagcagta      900

ctatgtcctg tgcagcagca gagacgagaa gttccaggcc ttgtgtaacc tctacggggc      960

catcaccatt gctcaagcca tgatcttctg ccatactcgc aaaacagcta gttggctggc     1020

agcagagctc tcaaaagaag gccaccaggt ggctctgctg agtggggaga tgatggtgga     1080

acagagggct gcagtgattg agcgcttccg agagggcaaa gagaaggttt tggtgaccac     1140

caacgtgtgt gcccgcggca ttgatgttga acaagtgtct gtcgtcatca actttgatct     1200

tcccgtggac aaggacggga atcctgacaa tgagacctac ctgcaccgga tcgggcgcac     1260

gggccgcttt ggcaagaggg gcctggcagt gaacatggtg gacagcaagc acagcatgaa     1320

catcctgaac agaatccagg agcattttaa taagaagata gaaagattgg acacagatga     1380

tttggacgag attgagaaaa tagccaactg agaagctcca ccagccactg atgccagccc     1440

tggcactgcc cctgcacagg agacaagtgc gttcagggca caggccccga catcacccca     1500

aggacaacgg cacaagtaga gagaaactac ctacctcact tcaaattatg tttggacttg     1560

acaaaaatgt atgcaaatga tgggggatgg t                                    1591


<210> 3528
<211> 1517
<212> DNA
<213> Homo sapiens

<400> 3528
gggggaattt agagcctcga ggcctggggt ggggacgcga ggacaccagc gtagaagagc       60

ttacatcaga atcgagcttt gtgggcgctc cgggatttgg ccctttagcg cggatcctag      120

acaacaggtt ttggacctcg agagctgcag aactgaggct actggtgccg ccagcctgct      180

ggctccgcct ctgcctcagt ttcttcccct atggcccgcg tgccgctggg gcggagtctc      240

actctgtcac ccaggctgga gcacaatggc atgacctcag ctcaccacaa cttccgcctc      300

ccaggttcaa gggattctcc tgcctcagcc tcccaagtag ctgagattat agatttggag      360

tggtatgaga agtccgaaga aactcacgcc tcccagatag aactacttga gacaagctct      420

acgcaggaac ctctcaacgc ttcggaggcc ttttgcccaa gagactgcat ggtaccagtg      480

gtgtttcctg ggcctgtgag ccaggaaggc tgctgtcagt ttacttgtga acttctaaag      540

catatcatgt atcaacgcca gcagctccct ctgccctatg aacagcttaa gcacttttac      600

cgaaaacctt ctccccaggc agaggagatg ctgaagaaga aacctcgggc caccactgag      660

gtgagcagca ggaaatgcca acaagccctg gcagaactgg agagtgtcct cagccacctg      720

gaggacttct ttgcacggac actagtaccg cgagtgctga ttctccttgg gggcaatgcc      780

ctaagcccca aggagttcta tgaactcgac ttgtctctgc tggcccccta cagcgtggac      840

cagagcctga gcacagcagc ttgtttgcgc cgtctcttcc gagccatatt catggctgat      900

gcctttagcg agcttcaggc tcctccactc atgggcaccg tcgtcatggc acagggacac      960

cgcaactgtg gagaagattg gtttcgaccc aagctcaact atcgagtgcc cagccggggc     1020

cataaactga ctgtgaccct gtcatgtggc agaccttcca tccgaaccac ggcttgggaa     1080

gactacattt ggttccaggc accagtgaca tttaaaggct tccgcgagtg aatgagtgct     1140

tcttaatcct aaaaacacaa tggctgaatt atctttctcc atgtggcgct gaatcaccca     1200

tctggtttgg agctagagtt gcttcctggt gagagaggaa gcaactctcc ttctggttgt     1260

ctgcctcccc tcagatttcc tgataggctg atggcatgtg gctgtgactg tgactgtaat     1320

cattgctgaa caacatctct ttgaatcaaa ggttgatttt cccagagggt gctgggtcag     1380

gcatttctat taggagttgg aaagcaaaaa tgggtccata gacactctat ggaggtgtcc     1440

ctttctgctc tttgctgtgt cctttcagaa tttttaccag gaacataatg tggatgtgac     1500

ttatgaactt aaatata                                                    1517


<210> 3529
<211> 871
<212> DNA
<213> Homo sapiens

<400> 3529
actcctcaca ccacttaaca gccacttgtt tcatcccacc tgggcattag gttgacttca       60

aagatgcctc agttactgca aaacattaat gggatcatcg aggccttcag gcgctatgca      120

aggacggagg gcaactgcac agcgctcacc cgaggggagc tgaaaagact cttggagcaa      180

gagtttgccg atgtgattgt gaaaccccac gatccagcaa ctgtggatga ggtcctgcgt      240

ctgctggatg aagaccacac agggactgtg gaattcaagg aattcctggt cttagtgttt      300

aaagttgccc aggcctgttt caagacactg agcgagagtg ctgagggagc ctgcggctct      360

caagagtctg gaagcctcca ctctggggcc tcgcaggagc tggggttcag acccagggtc      420

aggccactgg ctctgcgtgg gtcagcagct atgacaggca agctgagtcc cagagccagg      480

aaagaataag cccgcagata caactctctg ggcagacaga gcagacccag aaagctggag      540

aaggcaagag gaatcagaca acagagatga ggccagagag acagccacag accagggaac      600

aggacagagc ccaccagaca ggtgagactg tgactggatc tggaactcag acccaggcag      660

gtgccaccca gactgtggag caggacagca gccaccagac aggaagaacc agcaagcaga      720

cacaggaggc caccaatgac cagaacagag ggactgagac ccacggtcaa ggcaggagcc      780

agaccagcca ggctgtgaca ggaggacatg ctcagataca ggcagggaca cacacccaga      840

cacccaccca gaccgtggag caggacagca g                                     871


<210> 3530
<211> 682
<212> DNA
<213> Homo sapiens

<400> 3530
ggaaacctgt tgagatcaca gagaatatac tgacggcata aaagggcaga accatagcag       60

ggtgcgcctc gcagtcacct ctgtgccctg ctggttgtct tcccagcgct gctgtagttg      120

ccttccatgg atctatagga gagcaagtcc tccaggagaa gaagtcctca ccagtgaacg      180

gagacctctc tgaactaaga ataccatggc cacgtcagcc ccactacgga gcctggaaga      240

ggaggtgacc tgctccatct gtcttgatta cctgcgggac cctgtgacca ttgactgtgg      300

ccacgtcttc tgccgcagct gcaccacaga cgtccgcccc atctcaggga gccgccccgt      360

ctgcccactc tgcaagaagc cttttaagaa ggagaacatc cgacccgtgt ggcaactgga      420

aaaaatcctg aaccacctga gtaccctaag gagagacaga gacaaaattc agggcttcca      480

ggcaaaggga gaagctgata tcctggccgc gctgaagaag ctccaggacc agaggcagta      540

cattgtggct gagtttgagc agggtcatca gttcctgagg gagcgggagg aacacctgct      600

ggaacagctg gcgaagctgg agcaggagct cacggagggc agggagaagt tcaagagccg      660

gggcgtcggg gagcttgccc gg                                               682


<210> 3531
<211> 1960
<212> DNA
<213> Homo sapiens

<400> 3531
gattcccggg gttggtggca gcggcggtag cagcaatgga ctttctcctg gggaacccgt       60

tcagctctcc agtgggacag cgcatcgaga aagccacaga tggctccctg cagagcgagg      120

actgggccct caacatggag atctgcgaca tcatcaacga gacggaggaa ggtcccaaag      180

atgccctccg agcagtaaag aagagaatcg tggggaataa gaacttccac gaggtgatgc      240

tggctcacag tgctcgacgg cacctctcgg ccctccaggt cttagaaacc tgtgtcaaga      300

actgcgggca ccgcttccac gtgctggtgg ccagccagga cttcgtggag agtgtgctgg      360

tgaggaccat cctgcccaag aacaacccac ccaccatcgt gcatgacaaa gtgctcaacc      420

tcatccagtc ctgggctgac gcgttccgca gctcgcccga tctgacaggt gtggtcacca      480

tctatgagga cctgcggagg aaaggcctgg agttccccat gactgacctg gacatgctgt      540

cacccatcca cacaccccag aggaccgtgt tcaactcaga gacacaatca ggacaggatt      600

ctgtgggcac tgactccagc cagcaagagg actctggcca gcatgctgcc cctctgcccg      660

ccccgcccat actctccggt gacacgccca tagcaccaac cccggaacag attgggaagc      720

tgcgcagtga gctggagatg gtgagtggga acgtgagggt gatgtcggag atgctgacgg      780

agctggtgcc cacccaggcc gagcccgcag acctggagct gctgcaggag ctcaaccgca      840

cgtgccgagc catgcagcag cgggtcctgg agctcatccc tcagatcgcc aatgagcagc      900

tgacagagga gctgctcatc gtcaatgaca atctcaacaa tgtgttcctg cgccatgaac      960

ggtttgaacg gttccgaaca ggccagacca ccaaggcccc aagtgaggcc gagccggcag     1020

ctgacctgat cgacatgggc cctgacccag cagccaccgg caacctctca tcccagctgg     1080

caggaatgaa cctgggctcc agcagtgtga gagctggcct gcagtctctg gaggcctctg     1140

gtcgactgga agatgagttt gacatgtttg cgctgacacg gggcagctca ctggctgacc     1200

aacggaaaga ggtaaaatac gaagcccccc aagcaacaga cggcctggct ggagccctgg     1260

acgcccggca gcagagcact ggcgcgatcc cagtcaccca ggcctgcctc atggaggaca     1320

tcgagcagtg gctgtccact gacgtgggta atgatgcgga agagcctaag ggggtcacca     1380

gcgaagaatt tgacaaattc ctggaagaac gggccaaagc cgcggaccga ttgcccaacc     1440

tctccagccc ctcagctgag gggcccccgg gtcccccatc tggcccagcg ccccggaaga     1500

agacccagga gaaagatgat gacatgctgt ttgccttatg agtgtggggt ctggcaccct     1560

gcagcccagg tccccactgc tctcacaccc ttaggctggg acctccctcc ctcctctggt     1620

gttaaggctg ctttgggggt ggcttgttac ccccttttcc tcctctttga agacggagct     1680

gccccagctg tggctggggg tgtggaggca gtgggatgaa ctgggggaca ggtctgcgct     1740

gcagtgggat ctggctgctc tgcctccttt cccaccccag ctgaccatga gactttgctg     1800

agaagtggag gccccaggac aggctggctg gctggctggc tgcttgaccc agtgtgactc     1860

tccttcactg agtgataccc tgctccgggc ccatgcccca aggagccctt cagagcccac     1920

actgccagtc gaggcctggc tggaggctgg ccacagtgga                           1960


<210> 3532
<211> 474
<212> DNA
<213> Homo sapiens

<400> 3532
gagcccgtct attttgctga gaaggtgatg tcattaggca gaaattggca ccgaccgtgt       60

ctgaggtgcc agcgttgcca caagaccctg actgctggga gtcatgctga ggtgtgaaca      120

ttggcgatgt gggctgctac atctatgacc cagtgaagat aaaattcaaa tgagacgctc      180

acaaaaaagg tcaccctaac tcaggcctcc catcatgccc ctcatggtcc aatggaagct      240

acaaaaatct ccagtcccat gggggttggg gaaggtggga tcttgggggc ctgggcctag      300

gctccatggt aggccagaga gtctagactt tctctgccaa ttttttccct ttcccatttc      360

tatctggtta gggaacagcc cgttttgaag ggtatcctcc tcctggccat cacaacccct      420

ttccccagca cattctggag cttcaaggta ctcataaaac ttgtgtttat tgaa            474


<210> 3533
<211> 3424
<212> DNA
<213> Homo sapiens

<400> 3533
acaacgctac ttccggtctc ctcacttccg gcttcgctgc tcttggttct ggttctggag       60

gctgggttga gaggtcgccg gtccgactgt cctcggcggt tggtcagtgt gaatttgtga      120

cagctgcagt tgctccccgc ccccgagcag ccgaggagtc taccatggct caagaatctc      180

ccaaaaattc agcagcagaa attccagtga ctagtaatgg agaagttgat gactctcgtg      240

aacatagctt taatagggat ttgaagcatt cattaccatc tggacttggt ctctcagaaa      300

cccaaattac atctcatggc tttgacaata ccaaagaggg tgttattgaa gcaggagcat      360

ttcaaggttc cccagcaccg ccactgccat ctgttatgtc tcctagcagg gttgcagcta      420

gtcgactggc tcagcaagga agtgatttaa ttgttcctgc aggtggccag agaacacaga      480

caaaaagtgg accagttatt ctagcagatg aaattaaaaa tcctgcaatg gaaaagttag      540

aacttgttag aaaatggagt ctaaacacct ataagtgtac tcgacagatt atctctgaga      600

agctaggccg tggctcaaga actgtggacc ttgaacttga agctcagatt gatatattaa      660

gggataacaa gaaaaaatat gaaaatattt taaaactggc tcaaacattg tcgacccagc      720

ttttccagat ggtacatacc caaaggcaac ttggagatgc atttgctgac ctgagtttga      780

agtcactaga acttcatgaa gaatttggct ataatgccga tacccagaaa ctgctggcta      840

aaaatggaga gactcttctt ggggccatta attttttcat tgctagtgtg aacactttgg      900

tgaataaaac cattgaagat acattaatga ctgtgaaaca gtatgaaagt gccaggattg      960

aatatgatgc atatcgcact gatttggaag aactgaatct tggaccacgt gacgcaaaca     1020

ctctgccaaa gattgagcag tcacagcatc tcttccaagc acataaggaa aaatatgata     1080

aaatgcgcaa tgatgtttct gtcaaattga aatttctaga agaaaataag gttaaagtat     1140

tgcacaatca gctggtcctt ttccacaatg ccattgccgc ttactttgct gggaatcaga     1200

agcagcttga acagacactt aaacagttcc atatcaaatt gaaaacccct ggagtggatg     1260

ccccatcttg gcttgaagaa cagtaaaatc acagcggaaa ataaaaagaa agtcgcgttg     1320

ttatatttct aaaccaacct aacaagaatt aagcagagtt gggggaagtg ggaggggtga     1380

caagcattat agtgattctt gcacaaacag ctttaatttt tccctttttc atactttaac     1440

aattgaactg ttaagggtgg ttttaatgta aacatagttt ctataatctg aacacaataa     1500

ttttcctttt tgagaaatcc ttttgtattg tgagggttga tggctatttc tgtagtttga     1560

aaacatctaa tagagatttg cactgacaag ataaaaattc aaggtttttg gtcctggaaa     1620

tgagggccga ttgtaacttt tccaaaggga ggtttacatg atttgtatca acatcagata     1680

ttttatatgt gaatatatta aacatcttta agagattcat tttcatgtat taaagaaaaa     1740

agaaactatt ttgcagagta aagttatatg gtgttcctgc agcgtccaca cagaggcagc     1800

agctctaatg aatgattagc ttgtggagtt gtggcaaata cctttttaaa aatgaatctg     1860

taccactgta attttattta gacttttttt taaagacaca gaaatcacac tgtcatttct     1920

gtgaggcttt taagcttatg aatttgcttc acccgaagtc attggacagt tacatttgca     1980

atttcttttg gttcataaca aaacctgctt aagagaattt ttttttttga caggtggacg     2040

tgggaatgga aattcttaat ggtttctgga gtagaaatct gtacttagaa aactagtttt     2100

tgggtcagtt ccattttgat agaagtgaat acatagacag cttttattga cttccatatg     2160

taacaatacc gtttaagcct taaatcacag atatgtgcct tctcagatac agtaattctt     2220

gttcaaccaa tgtacaaaat ccataaagaa acccctgttg gataatgttt gatgtgtcta     2280

ttccttccat ggaatggagc actatgtatg aatgttgggt ttctttgtac ttgttaagcc     2340

acatttgagg tttatggtaa aaatcatctt ttgagtttgc tctttggttt ttcttcattc     2400

cttttgagga ttgggaaaac agaaagattc tttgatttgg gtaatgaaga ggtaatttgg     2460

gacagtgtgg tggtaccagg aagaaagagg attggaaagg ccagtactgt tttagttgct     2520

cggcactgtt ggttttgttt taatgtggtt gccctgtcca ctacatggtt ctatcagtag     2580

tgtaatccat tttcaatgta aagctctttt agtttttgtc atagacataa attaatattt     2640

tgagaggcat ccctcacctg ttcatttctt ctgtgttgaa atgaagtact taaaattacc     2700

gttatacatg aactttgtgg actgtaagat ttgttatata tgttcaaatg ccttttagct     2760

ggctttttaa ttaatatgcc tgttttgagt gcttaataca atgtaatgtg attgtaaatc     2820

atacctattt taaatcattc cttcctgtat atttgtactc agagagcctt attttattct     2880

tccagcagaa ttactacttg tgatagttca tttacattcc ccagaatgtg cctctagtgt     2940

gaattttgta ttcttattaa acgtgtttgc tgcagtaaat cgtttctctg gaccttcata     3000

gtttaagaag taactatttg gaaattctga agacacataa tttgcgtttt ctgaacctta     3060

aaaaaaaagg tacttctgtc acttataatt gttttagctc agtaagctat tttttttcaa     3120

tgtgaatctc ttttgagagc tgaacatgtc cattcttaac cacatttcaa taacagttac     3180

tgtagctaag gagctaaata gtttcatgga ttaatttttt tcagaataaa tttaaaatat     3240

ccatgattct gatagtgggc acatgaccaa aagaaaaaag taaatcaata tatttagcca     3300

atggtacatt tactttgtta ggaatgtaat ttatgttcat tatagaaaag aattagaaga     3360

aaatttcaag taatagaaga taagtacctt cccaagtgaa taaatactgc atggaaccac     3420

tcaa                                                                  3424


<210> 3534
<211> 583
<212> DNA
<213> Homo sapiens

<400> 3534
cacagttccc ggtccctaga caaccctggc tctgcccgcc cacttcgcgt gttcgattgg       60

cttgtccttc ccctttctaa gaccggagac taaggcggct tatgacccct acgcttatcc      120

cagcgactat gatatgcaca caggagatcc aaagcaggac cttgcttatg aacgtcagta      180

tgaacagcaa acctatcagg tgatccctga ggtgatcaaa aacttcatcc agtatttcca      240

caaaactgtc tcagatttga ttgaccagaa agtgtatgag ctacaggcca gtcgtgtctc      300

cagtgatgtc attgaccaga aggtgtatga gatccaggac atctatgaga acagctggac      360

caagctgact gaaagattct tcaagaatac accttggccc gaggctgaag ccattgctcc      420

acaggttggc aatgatgctg tcttcctgat tttatacaaa gaattatact acaggcacat      480

atatgccaaa gtcagtgggg gaccttcctt ggagcagagg tttgaatcct attacaacta      540

ctgcaatctc ttcaactaca ttcttaatgc cgatggtcct gct                        583


<210> 3535
<211> 2663
<212> DNA
<213> Homo sapiens

<400> 3535
gtgcaacggc cgttagagga gctgagggag ggaaccaccg ctcaccgcag acgtggtggc       60

tgcagtcagt cttcccgagt gagggatttc gccgcccgct ttcaggcccg tttggcttaa      120

ataactgtga ttgatggcca tgcaggagaa atatccaact gaggggatct ctcacgtcac      180

ttcaccgaat ttttgcagct caagtggcag tcctcctttc cagcccatca aaagccacgt      240

aaccattcca acagcccatg tgatgccttc tactttaggg acctctcctg ccaagccaaa      300

ttctacacct gttggaccct cttcctctaa actccctttg tcagggttgg ctgaaagtgt      360

gggaatgaca agaaatggag acctcggtgc aatgaaacat tctccaggcc tatctagaga      420

tctcatgtat ttctctggtg ctactggaga aaatggaatt gagcagtcct ggtttccagc      480

agtgggccat gaaagacaag aagaggcgag gaagtttgat attcctagca tggaatctac      540

cctcaatcag tcggcaatga tggagacact ttattcagat cctcaccacc gagtccgctt      600

ccacaaccca agaaccagca caagtaagga gttgtacaga gtgttgcctg aggccaagaa      660

ggcaccgggc agcggggcag tgtttgagcg gaatggacca cattctaata gcagtggggt      720

cctccctttg ggactccagc ctgctcccgg gctctccaag cctctgccct ctcaggtgtg      780

gcagccgagt cctgacactt ggcatccccg agagcaatct tgtgaactca gcacttgtcg      840

gcagcagctg gaattgattc gtttacagat ggagcaaatg cagcttcaga atggagccat      900

ctgccaccat cctgctgctt ttggtccttc actgcccatc ttagagccag cacagtggat      960

cagcatcttg aacagtaatg aacaccttct gaaggaaaaa gagcttctca ttgacaagca     1020

gaggaaacac atctctcagc tggagcagaa agtgcgagag agcgaactgc aagtccacag     1080

tgccctcttg ggccgccctg ccccctttgg tgatgtctgc ttgctgaggc tacaggaatt     1140

gcagcgagaa aacactttct tacgtgcaca gtttgcacag aagacagaag ccttgagcag     1200

agaaaagatt gaccttgaaa agaaactctc tgcttctgaa gttgaagtcc agctcatcag     1260

agagtcgctc aaagtggcgt tgcagaagca ttctgaggaa gtgaagaaac aggaagaaag     1320

ggtcaaaggt cgtgataaac atatcaataa tttgaaaaag aaatgccaga aggaatcaga     1380

gcagaaccgg gagaagcagc agcgtattga gaccttggag cgctacctgg ctgacctgcc     1440

cacactggaa gaccatcaga agcagagcca gcagcttaag gattctgagt tgaagagcac     1500

agagctgcag gagaaagtga ctgagctgga gagtttgctg gaggagaccc aggcaatctg     1560

cagagagaag gagattcaac tggaaagcct gaggcagaga gaagcagaat tctcctccgc     1620

tggacatagc ctgcaagata aacagtctgt ggaggagacc agtggagaag gtccagaagt     1680

ggaaatggag tcctggcaga agcgatacga ttcgctccaa aagattgtgg agaagcagca     1740

gcagaagatg gatcagttgc gctcacaagt acagagccta gagcaggaag tggctcaaga     1800

agaaggaaca agccaggccc tgagagagga ggcccagcga agggattcag ccctgcagca     1860

gctgcgcaca gccgtgaagg agctttcagt gcaaaaccag gacttgattg agaagaatct     1920

gacactccag gaacacctgc gccaggccca accagggtct ccaccttcac cagacacggc     1980

ccagctggca cttgagctgc accaggagtt ggccagttgc cttcaagatc tgcaggctgt     2040

ctgtagcatt gtgacccaga gggcccaggg ccatgacccc aatctctccc tgctcctggg     2100

cattcactca gcacagcacc cagagactca gctagatttg cagaagccag atgtgatcaa     2160

gaggaaacta gaagaggttc aacagctgcg tcgtgacatt gaggacttaa ggaccaccat     2220

gtcagacaga tatgcccagg acatgggaga aaactgtgtc acacagtgag gaattctggg     2280

ggattccccc agggaggagc tgggctgctg agagcctagt ccagcaggtt tctgccctga     2340

cattctcttg tctgctattc ccagagaggt ctcagagggg aggggagagc ctgcatctgg     2400

gggccaaggg ctgattaggg aactgtgtcc tacccacact ggcatgttgg attacgtttg     2460

tcctgttaat tcactctaga cggtgagtta ctaattaact tttggcaggt acaacagata     2520

agtcctcaca aactgttccc agccctaggc tgacatgaga gacgaacagg ctgtccacct     2580

ttcttctcca tccaatggga tggatccatg ttcattccca cttcacacct tggtcctgct     2640

gattagagag ctcatcagag ggg                                             2663


<210> 3536
<211> 972
<212> DNA
<213> Homo sapiens

<400> 3536
ggcatgcctc tgctcctttg cgcacgcgcg ccgcttccca gtggcaagcg cgggcaggac       60

cgcgttgcgt catcggggcg cgcgcctcag agagagctgt ggttgccgga agttgagcgg      120

cgagcagcct tgtgagagac atttctgaga cctgtatgtc ctgcgtctat gattcttccc      180

tgatcaaggc ttctcaaacc ccataatgct ggtatccagt gcatccgttc tcaaaaactg      240

aagctgatgg acaccagatt gcatgtgaag gtgaaggata ttatagcaga aggaaaccaa      300

aataaaagaa aaacagctcc tggaagtaac caatgagaag gacagataag agtttgaaga      360

ctgtggatgt gactgcttgt tccctggttg acacactgaa gaagaaatca tgttgattca      420

gagttggctt ggaggcaaga aataatggcg gcagctacgg gggatcctgg actctctaaa      480

ctgcagtttg ccccttttag tagtgccttg gatgttgggt tttggcatga gttgacccag      540

aagaagctga acgagtatcg gctggatgaa gctcccaagg acattaaggg ttattactac      600

aatggtgact ctgctgggct gccagctcgc ttaacattgg agttcagtgc ttttgacatg      660

agtgctccca ccccagcccg ttgctgccca gctattggaa cactgtataa caccaacaca      720

ctcgagtctt tcaagactgc agataagaag ctccttttgg aacaagcagc aaatgagata      780

tgggaatcca taaaatcagg cactgctctt gaaaaccctg tactcctcaa caagttcctc      840

ctcttgacat ttgcagatct aaagaagtac cacttctact attggttttg ctatcctgcc      900

ctctgtcttc cagagagttt acctctcatt caggggccag tgggtttgga tcaaaggttt      960

tcactaaaac ag                                                          972


<210> 3537
<211> 1545
<212> DNA
<213> Homo sapiens

<400> 3537
gccagaggag cggctccggc cgccgcgcct gacccttgtc cggggtcttc cgcacagtgg       60

gctgagggcc atgtcagttt tctgccacct acaggataga ccatgaagct gaaggaactt      120

gagcggccag ctgtccaggc atggagccca gccagccaat accctttgta tctggccaca      180

ggaacatctg cccaacagct agattcctcc ttcagcacaa atggcacatt ggaaatattt      240

gaggttgatt tcagggaccc ttctctggac ttgaaacaca gaggagtcct ttctgccttg      300

agcaggtttc acaagctggt ctgggggagc tttggcagtg ggcttctgga aagctccggg      360

gttattgttg gcggcgggga caatggcatg cttattctat acaatgtgac ccacatcctg      420

tcttcgggga aggagcctgt gattgctcag aaacagaagc acacgggggc tgtcagagcc      480

ctcgacttga atcctttcca gggcaacctc ctggcttcag gggccagcga ttctgaaatc      540

ttcatttggg atctgaataa cttgaatgtg ccaatgaccc tgggatccaa gtcacagcag      600

cctccagagg acatcaaggc actgtcttgg aaccggcaag cccaacacat tctgtcttct      660

gctcacccca gtggcaaggc agttgtgtgg gatctcagga agaatgaacc tatcatcaaa      720

gtcagtgatc acagcaacag gatgcactgc tcaggcctgg cctggcatcc tgacatagcc      780

acccagttag tgctgtgctc agaggatgat cgacttcccg tgattcagct gtgggacttg      840

cgctttgcct cctcgccctt gaaggtgctg gagagccaca gcagggggat cttgtcagtg      900

tcatggagcc aggctgatgc tgagctgctg ctcactagtg ctaaggacag ccagatcttg      960

tgccggaacc tggggagcag tgaggtggta tataagctac caacacagag cagctggtgc     1020

tttgatgtgc agtggtgccc tcgggaccct tcagtgttct ctgctgcctc cttcaacggc     1080

tggatcagtt tgtactctgt gatgggtagg agctgggaag tccagcatat gagacaggct     1140

gacaagatct cctcttcctt cagcaaaggc cagcctctcc caccactgca ggtgccagag     1200

caagtggcac aagcaccact gatacctccc ctgaaaaaac cccccaaatg gattagaaga     1260

ccaacaggtg tttcatttgc ttttggaggg aagctggtta cttttggcct ccccagcacc     1320

cctgcccatc tggtgccaca gccttgcccc cgcctagtct tcatcagtca agtcaccaca     1380

gaatctgaat tcctgatgcg atcagctgag ctgcaggagg ccttgggatc aggaaatcta     1440

ctgaattact gtcagaacaa gagccagcaa gctttactgc aaagtgaaaa gatgctgtgg     1500

cagttcctga agcccgccag agacagctca ggtgcaagga gatga                     1545


<210> 3538
<211> 2853
<212> DNA
<213> Homo sapiens

<400> 3538
cctccctcca gtctccggat ctccctcggt ccctctctcc tcctcttcct ctctctggac       60

gcccggctcc tccgcacccc ctcccccggg ggtcccgcgg ccttgctccc taccctcacc      120

tcaagacgac catggccacc atcccagact ggaagctaca gctgctagcc cggcgccggc      180

aggaggaggc gtccgttcga ggccgagaga aagcagaacg ggagcgcctg tcccagatgc      240

cagcctggaa acgagggctc ctggagcgcc gccgggccaa gcttgggctg tcccctgggg      300

agcctagccc tgtgctaggg actgtagagg ctggacctcc agacccggat gagtctgcgg      360

tccttctgga ggccatcggg ccagtgcacc agaaccgatt catccggcag gagcggcagc      420

agcagcagca gcaacaacaa cggagtgaag agctgctagc agagagaaag cctgggcctc      480

tggaggcccg ggagcggaga cccagccctg gggagatgcg ggatcagagc cccaagggaa      540

gagagtcaag agaagagaga ctaagtccga gggagaccag agagaggagg ctggggatag      600

ggggagccca agagttgagc ctgaggcctc tggaggctcg ggactggagg caaagcccag      660

gagaggtggg agacaggagc tcccgactgt cagaggcatg gaaatggagg ctgagtcctg      720

gagaaactcc agagcggagt ctgagactag cagagtctcg agagcaaagc cccaggagaa      780

aagaggtgga aagtagactg agcccagggg aatctgccta ccagaagttg ggcctgacag      840

aggcccataa atggagacct gactccagag agtctcagga acagagtttg gtacaactgg      900

aggcaacaga gtggaggctg aggtcaggag aagaaagaca agactactcg gaagaatgtg      960

ggagaaaaga agagtggcca gttccagggg tagctccaaa agagactgca gagctgtccg     1020

agaccctgac aagggaggcc caaggcaaca gttccgcagg agtggaggca gcagagcaga     1080

ggcctgtgga agatggcgag aggggcatga agccaacaga agggtggaaa tggaccctga     1140

actccgggaa ggctcgagaa tggacaccca gggacataga ggctcaaact cagaaaccag     1200

aacctccaga gtcagcagag aagcttctgg aatctcccgg tgtggaggct ggagaagggg     1260

aggctgagaa ggaggaggcg ggggctcagg gcaggcctct gagagccctg cagaactgct     1320

gctctgtgcc ctcccccctc ccaccagagg acgctgggac tggaggcctg agacagcagg     1380

aagaggaagc agtggagctc cagcccccac caccagcccc tctgtctccc ccacccccag     1440

ccccaactgc cccccaacct cctggggatc ccctcatgag ccgcctgttc tatggggtga     1500

aggcagggcc aggggtgggg gccccccgcc gcagtggaca caccttcacc gtcaaccccc     1560

ggcggtctgt gccccctgcg accccagcca ccccaacctc tccagccaca gttgatgctg     1620

cagtcccggg ggctgggaag aagcggtacc caactgccga ggagatcttg gttctggggg     1680

gctacctccg tctcagccgc agctgccttg ccaaggggtc ccccgaaaga caccacaaac     1740

agcttaagat ctccttcagc gagacagccc tggagaccac gtaccaatac ccctccgaga     1800

gttcggtact ggaggagctg ggcccggagc ctgaggtccc cagtgccccc aaccctccag     1860

cagcccaacc cgacgacgaa gaggatgagg aagagctgct gctgctgcag ccagagctcc     1920

agggcgggct gcgcaccaag gccctgattg tggatgagtc ctgccggcgg tgaccatctt     1980

ccaacatagg gatatacctc cctccttctt ataactgaag atcctggagc ccggaagatt     2040

cagggcagac agaccctgat aatgagcctg gcagggaagg gcaaccaaca tcttgtaact     2100

tgctttcccc accctgtttc tgggggcaga gccaattgcc caatttctac cctaatccaa     2160

agtccctggt gtgggtgggg ttaaacgtgc tggtgcatcc taggtcatcc aagagtgagc     2220

gccaagtcct gagaaggggc acagaactcc ctggagggtg gagatggagc acctgccccc     2280

catggcaggg tacactctcc ccacagcctt cctccccacc atcccgtggg gactctcggg     2340

atttaagcac tcgtctctct gggaggccca gaccccactc catttatagg cacatctcct     2400

tcatttccta ggtcactgcc cctttgttta cagctcctgc ctcctccctt gaccacagcc     2460

tggtttacaa attccatcag ctcccagccc cacctgccaa agtcccaggt ttacaagcca     2520

cgcttacttg ctgtgtctgc gtggaattct ctcctctgtc ccctccagtc tcctcattgg     2580

agtgacctga aggtgtggct tcctccactt tttctcagta ttactttgcc ttagttttcc     2640

ccaagaggga aggctggaac tcttaactct gtaccccttg atagttattt aattctgttt     2700

ctcctagtgg ttcacaattg aactgaattg agatggtgtc gggtggctaa ggagacacct     2760

cacctctcct tccccattgt gccgccttta tcaattgcct gttttgtttt gtttgttttt     2820

taactttcca taataaaatg gagttctctt caa                                  2853


<210> 3539
<211> 3546
<212> DNA
<213> Homo sapiens

<400> 3539
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact     1560

catatcaacc caagtaccat gtggacttga tccctggctg aatcacctgg atgacttgga     1620

atagaaatga ctgctttaga agatgggatg gggccgggtg gtaagggata gaagagagga     1680

ctctcaatct actgatcaag tcctttcccc aatgcccagt ggatggccag ggtacctggg     1740

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1800

tagaaagggc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1860

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1920

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1980

agtgtggtgg ccactggtga cttgaaaata tagagaaaaa aaaaacctgc tctatatctg     2040

aaagagctct tgggaagaca gagaaacata aagaggaaat tacagcacag tgtggtgggt     2100

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     2160

ggaaggagag ggtgagtggg ggatggcttt ctgaaaaggg tggtctaaag gatgcctatg     2220

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     2280

ggatgacctg tgactctgga gcactgggtt gtctccattg tcattatggg cagatgtgtg     2340

ccatccccag ccgacgccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     2400

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     2460

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     2520

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2580

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaacttta     2640

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2700

ggaagagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2760

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gtgtaaacta     2820

caatgctctg tcatctccct actgggtctc ctgggaggag gggagccatc cagggtgcaa     2880

actcaaaggc agagggcaca gcgtgcttag gcccaagctt agaattcaat tgagaagttc     2940

tgttgttcat ccttacctca gcaggtagaa aagaggtgga gatcagaagc cagggattag     3000

agattgaatt gctttccctg ggagtgtgca gtatctcatt aaaatgttgt atattcaaaa     3060

aaatacagac acacacaagt gcctatataa tgataaaaca tatccaaagc acccaaacct     3120

gtgattccag aaaagtagat cctatttttg tttattttta ttggctttag ctgtgtcttt     3180

tgaaaggact attatcctct aaaatgtatg tgtatgaaga tcctggcttg cagctcggga     3240

gctttacaca ccttgtgtca ctttatcttg gtaacgagcc aagatcatgc aaccagttca     3300

tccatgtctg acccaagagc tcttaactgc tatgctgcac tgcctcattc agagatagat     3360

gcctgcatgg gtcctggcga ttattttaat gctggctaca cccccacagg tgacttggat     3420

tcagaaatac aatttatatt tcttcttttt aaattgtttt attttatttt tcttttaata     3480

gttatatgtc agtgagaaca atttatatgt cttacactga gaaataaaac tgctcataag     3540

tgaaaa                                                                3546


<210> 3540
<211> 1641
<212> DNA
<213> Homo sapiens

<400> 3540
cgtgtgcaga cccgcgtgtg gcgcaggcaa ggaccctcaa aataaacagc ctctaccttg       60

cgagccgtct tccccaggcc tgcgtccgag tctccgccgc tgcgggcccg ctccgacgcg      120

gaagatctga ctgcagccat gagcagcaat gagtgcttca agtgtggacg atctggccac      180

tgggcccggg aatgtcctac tggtggaggc cgtggtcgtg gaatgagaag ccgtggcaga      240

ggtggtttta cctcggatag aggtttccag tttgtttcct cgtctcttcc agacatttgt      300

tatcgctgtg gtgagtctgg tcatcttgcc aaggattgtg atcttcagga ggatgaagcc      360

tgctataact gcggtagagg tggccacatt gccaaggact gcaaggagcc caagagagag      420

cgagagcaat gctgctacaa ctgtggcaaa ccaggccatc tggctcgtga ctgcgaccat      480

gcagatgagc agaaatgcta ttcttgtgga gaattcggac acattcaaaa agactgcacc      540

aaagtgaagt gctataggtg tggtgaaact ggtcatgtag ccatcaactg cagcaagaca      600

agtgaagtca actgttaccg ctgtggcgag tcagggcacc ttgcacggga atgcacaatt      660

gaggctacag cctaattatt ttcctttgtc gcccctcctt tttctgattg atggttgtat      720

tattttctct gaatcctctt cactggccaa aggttggcag atagaggcaa ctcccaggcc      780

agtgagcttt acttgccgtg taaaaggagg aaaggggtgg aaaaaaaccg actttctgca      840

tttaactaca aaaaaagttt atgtttagtt tggtagaggt gttatgtata atgctttgtt      900

aaagaacccc ctttccgtgc cactggtgaa tagggattga tgaatgggaa gagttgagtc      960

agaccagtaa gcccgtcctg ggttccttga acatgttccc atgtaggagg taaaaccaat     1020

tctggaagtg tctatgaact tccataaata actttaattt tagtataatg atggtcttgg     1080

attgtctgac ctcagtagct attaaataac atcaagtaac atctgtatca ggccctacat     1140

agaacataca gttgagtggg agtaaacaaa aagataaaca tgcgtgttaa tggctgttcg     1200

agagaaatcg gaataaaagc ctaaacagga acaacttcat cacagtgttg atgttggaca     1260

catagatggt gatggcaaag gtttagaaca cattattttc aaagactaaa tctaaaaccc     1320

agagtaaaca tcaatgctca gagttagcat aatttggagc tattcaggaa ttgcagagaa     1380

atgcattttc acagaaatca agatgttatt tttgtatact atatcactta gacaactgtg     1440

tttcatttgc tgtaatcagt ttttaaaagt cagatggaaa gagcaactga agtcctagaa     1500

aatagaaatg taattttaaa ctattccaat aaagctggag gaggaagggg agtttgacta     1560

aagttctttt tgtttgtttc aaattttcat taatgtatat agtgcaaaat accatattaa     1620

agaggggaat gtggaggact g                                               1641


<210> 3541
<211> 550
<212> DNA
<213> Homo sapiens

<400> 3541
agctgcgacg ccgagtttca ctctggctgc cttctcctga gagtcggagc cacagccaga       60

gccctgccca ggccgagccg gagctgcagc ccgagcgcgg tggtgccctc agccccgtcc      120

tcttgtcctc ctcagcctcg gctgtttttg cagagttgtg agagttggtt catccgggcc      180

atgaggacat gttgggacat accccgtgtg ccgatgatgg aggcggccgt ggctgcccga      240

gagatgcgtg acacccagga gtaattggct tggaaggcag tcctctgatt tgtacctcat      300

tgtggttaca gaaacttcca attgaagaca ctgagctgaa ccattccgcc cgcccgcccg      360

cccgagggca ctccagatct gccggaggcg ctgggcaatg accccgggac tccaggccag      420

aggggtctga agctgtttgg gaaagcagcg ggactccttg ggaagatggc catggcccca      480

agcccttccc tggtgcaggt gtacaccagc cccgcggctg tggccgtgtg ggaatggcag      540

gacgggctgg                                                             550


<210> 3542
<211> 4307
<212> DNA
<213> Homo sapiens

<400> 3542
acgtgcttag gagccatatt gtcgctagtg gccgctgggg ctgggagggg tgtgctagag       60

aggcgcagct tctctgggcg tggtttttat cctgggggaa ggatcggtgg aatgtgaggg      120

gaggtggagg agatggcggc gacggcccgg gaagatggcg ccagcggtca agagcgaggt      180

cagcggggct gcgagcacta tgacagagga tgtctcctaa aggcaccttg ctgtgacaag      240

ctttatactt gccgcttgtg tcatgataac aatgaagatc atcaactaga tcgctttaaa      300

gtgaaggaag tgcagtgcat aaactgtgaa aaaattcaac atgcccaaca gacttgtgaa      360

gaatgtagca cattgtttgg agaatattat tgcgatatat gccatttgtt tgacaaagat      420

aagaagcagt atcactgtga aaactgtgga atttgtagga ttggtccaaa ggaagatttt      480

ttccattgtt tgaaatgtaa cttatgccta gctatgaatc ttcaaggaag acacaagtgt      540

attgaaaatg tgtcccgaca gaattgtcca atatgtttgg aggacattca cacatcccgt      600

gttgttgctc atgtcttgcc atgtggacat cttttacata gaacgtgtta tgaagaaatg      660

ttgaaagagc tacagatgtc cattatgtat gcactctgct ttagatatga ccaggtattg      720

gagacagctg gatgatgaag tagcacagac tcctatgcca tcagaatatc agaacatgac      780

tgtggatatt ctctgcaatg actgtaatgg acgatccact gttcagtttc atatattagg      840

catgaaatgt aagatttgtg aatcctataa tactgctcaa gctggaggac gtagaatttc      900

actggatcag caatgacgag cctacacagt actggagaac ttggcatttt ctgatataga      960

aaaaggcttt ccttggtatc gtgttatcat gtgtcgtcat ctatgcatta gagttgatgt     1020

gttttgtact agtgtcacag cataaaatca tattacaagt acgtaaggat tcagggtctc     1080

ttgatagact tatcatagct ctatattgaa tgaaagccac tgtgcttgtg ttttgattgg     1140

aaattccttt agtgtcagtt ttttggaagc caatgatgtt tgccactgat acattcatag     1200

aagtgtatta tattttcatg aagctttgct ttaagtgaca ctacgcgtgc agttcatttc     1260

tagttcttga tagaactgca cttaattttc agtagtagtc ttgacttttt aagggctgtg     1320

ttatattaag ttctccctta ctgttaaaac ctaattaaat atgctttaga attttctaag     1380

acagtcctct ggatcctcta aatgtgaatt ttgatgtaat aactgctaat aaaattatat     1440

tgaaactgtt ttatagaaag ttttttccaa agttttctat gtttggctca attagggcag     1500

tatcatcagt tctataatgt aaaagaaatt ttctttcttt tgaggtattc cataaaagta     1560

gttgggaaaa ttattatgta aaataataag actcttccaa agccttaata aaaacatcaa     1620

cattgaaaac agtttttttt aggttgccca aaattatttc ttcaaagagt cattcattcc     1680

ttcatttagc aagtatttat tgagcaactg ctatgtggca gatatgtttc tagatgctgt     1740

agagacaaca gtgaacaata aagataaaag tccttgtcct cacagcagta cattctattg     1800

ttcatcatat ttgatcaatg tactcatttt tctttatgca aggagtggat gtcttattgt     1860

aaatgaatag aatatttctt ccctaagcgt gtgaaaatag gggatggatg agtgggaagg     1920

gcatgggata ttcctggcaa gatctctgat ttcataatac ttttttgggc tcatgtagtg     1980

gaattaaata tacctcttac ttcaggaaca aagttaacaa atatgtttga tgatccagcc     2040

gactttgaca ctgttatctc cgtaatagct ttaccattag gctaggatgt aaaatgtaca     2100

tttatcagtt gataagtacc tattgagcac cagttgtatt tccaactttg agctatttga     2160

atcttctttg aataaggaag ttagcctttt aactagaaag cctaagagtt ctggcacatt     2220

tatttcttct tttgttgaaa tttattcacc tagataaagg cagcagtttg ggactcagat     2280

ctttatttta tcccaccttc ttgtcttctg tattccactc ttcttatgtt ctttcccttc     2340

atctgtttcc ttggcctggc cagagcagca gtgctgatct tcatttggga aaggatgttc     2400

ctgggtatta ccaattagta tacagataag taaagactag ttttccagat ctaatacttt     2460

tttttgaagt ggttttgctc tgtcatttag gctagagtgt agtgaagtga tcgtagctca     2520

ctgcagcctt gacttcctgg gctgaactga tccttccacc tcagcctcct gagtagctgg     2580

gactacaggt gtgtgccacc atgcccagct aatttttaat tgttttgtag aaacaaagtc     2640

caggctggtc ttgaactcct gggctcaagc atttctccta cctcggcctt ccaagggcta     2700

ggattacagg catgagccac tgtgcttggt ccagatgtat tactttttat gtttggtatt     2760

attctgccaa accaatcatg ttattgtttt taatcattga atcattggat ctttaaatag     2820

gagtgagtat ataataataa ggctcttctg ttttcaacat ctgtgctggg tcatgcatta     2880

gcattaatta ctacaatgat tctgtggggt aagtgttgtc ctcatagaca agaaagctga     2940

ggtttagagg ttaaaatgac acattggggg taaataacag acactatatg ttggagttgg     3000

gaatcagatc caagtttgac tccaaaccca cttttaccac attgcttttg atctaaactt     3060

ctattttgct aaaatacccc tcacagctag tcatccatat cattgaagcg ctcatgattt     3120

gatagattaa cctttcattt ttttaggtga ctctagttag aaagtcttat ttcacaatct     3180

gattgtttct ttaacttagg atccaaacat gtccaaaata atgcagagta catatgcaat     3240

cactcgttta tgctgtctag tcatgcactt aaagcaattt tcaaatgtac tcaaagtctc     3300

taggcttcgg tacccagggt tgcttcaagt atttgttcat gacacgtcaa ctcgatgatt     3360

aaaatccttc aacacttctc attcacaata agaataaaat ctacatccct taccattcag     3420

tatgcaaaac ttaaaataca taactttacc cttaaatatt ttttctttct ctgacttcat     3480

aagtataggt tatacctcta taagaaagaa ggtaaaaaac tctcaacaat cccttctttc     3540

agagagaact actgttaaca ttttaacaga caacttcatt cttttcctat tcttttttat     3600

aatgcttaca ggaatgttaa atacttagac agatcttaag tacactagaa ttatctgtcc     3660

ctgaaataag ttaggttgcc ctgccgcaga atttgtatct atagtttatt tggattattt     3720

ttgaaaaaag taaaataaca atacccttac gaattttttg gtgcatagca tctcagcttc     3780

ttttatcatt aaagatgtat gtataaaaaa aaaatgagtg tatatcaagt tgttcatttc     3840

ttagtttctg gggtcttctt aaccagtaca tagaactctt tatgaattaa ctttagctta     3900

tgttggaagt agtagtttgt ttatagtgtc atggatttta aaatcaaact cagtttttat     3960

ttcttcacta aaacctattt tcatatgata tacatgttaa atttcccttt tattttggtc     4020

atgcatcaaa ataaatttac taagtactaa agagccaaca ttattttata agtgcctggc     4080

aataggtatt cactagttga atagtttaat ttgaaatgaa ttaattttaa atgggagttg     4140

ttcaaaacta tgccactttt tcttttgtcc tttgtgttat taaaatttaa ttgataattg     4200

tgtatattat atatatggag tacaatgtga tgttttgata tatgtttaca gtgtagaatg     4260

attaaatcaa tgtaataaat ttattgcctc ataccatttt ttgtggt                   4307


<210> 3543
<211> 646
<212> DNA
<213> Homo sapiens

<400> 3543
gcggaagatg gcgacgcccc tcgggtggtc gaaggcgggg tcaggatctg tgtgtctcgc       60

tttagatcaa ctgcgggacg tgattgagtc tcaggaggaa ctaatccacc agctgaggaa      120

cgtgatggtt ctccaggacg aaaattttgt cagtaaagaa gagttccagg cagtggagaa      180

gaagctggtg gaagagaaag ctgcccatgc caaaaccaag gtcctcctgg ccaaggaaga      240

ggagaagtta cagtttgccc tcggagaggt agaggtgcta tccaagcagc tggagaaaga      300

gaagctggcc tttgaaaaag cgctctccag tgtcaagagc aaagtccttc aggagtccag      360

caagaaggac cagctcatca ccaagtgcaa tggtaggcgg gaggcccgtg ctctccacca      420

cggttatata aacgggctct ttcctaacca cccagtgcct gtgtcaaagg cagggtttca      480

ctctaacacc tgtccccagc tgaggataca ggcaggcccg ggtgggccac accttcgaaa      540

aggccttaag ggaccaggca ggccacggaa atgagggaag cagtcggtgt actatattct      600

tcaccgccat aaaggaatgg gcttgctccc atttttcctg aaacat                     646


<210> 3544
<211> 950
<212> DNA
<213> Homo sapiens

<400> 3544
ccccaacccc cctgctgggc cgggtaggcg tttcagtctt tcgcggcccg ggagctcagc       60

agagctacca gctgccctgt tggcttcgct ggtcggatcg tcctcctggc cccgccaaac      120

aggcgggggg agcggccccg actgtggggc catggcagta gtctcctcgt tcgccgccgc      180

cgctagccta gctgagtcgc cggcttctgc gctaggggct cccaccgcct ccgcaggcta      240

aggagccgct gccaccaacg agctgtgagg gttactatgc tccctctttg ccgccgtctc      300

ctcctcttgc ccgcgcaggc acccctctgg ctgctcagtc ctgcctcagt gtcaaaccag      360

aagagaagta aaattcaaca aaaatttatg tgtggagttc cttcttaaaa gaagaaaaaa      420

gtgattattt agactatgga tcggagcaaa cggaattcaa ttgcaggatt tcctccacgt      480

gtggagcgtc ttgaagagtt tgaaggaggt ggtggaggag aaggaaatgt gagccaggtg      540

ggaagagttt ggccatcttc gtatcgagct cttataagtg ccttttccag actgacgcgt      600

ttggatgatt tcacctgtga aaaaataggg tctggcttct tttctgaagt gttcaaggta      660

cgacaccgag cttctggtca ggtgatggct cttaagatga acacattgag cagtaaccgg      720

gcaaacatgc tgaaagaagt acagctcatg aatagactct cccatcccaa catccttagg      780

tgcagaagta tgaaccagaa tttttcccca aattgagatt agatctacat tgggaagaat      840

ccatctcttg gaaccctagg attacacaga tgtgccttct caggtcctag tccaatggag      900

gttgggtaga ggtggaagga gagctcattt tcacctagaa gagggcctca                 950


<210> 3545
<211> 4617
<212> DNA
<213> Homo sapiens

<400> 3545
actgccgctg ccgcggctac ctgcggttca tctccgcaca ttccacacgc ggcccaaacg       60

gtctctctct ctctctctca aacaccgcct ttccgtcttt gttttatctt gagtagctta      120

gaaagattgg agaagaaagc ttacgtggaa tgaaaatcaa cttttatgga tattttgagg      180

actaaaagaa taaatagggc gtccgtactg tagcgaaagt gcgactaagg ttaggcatct      240

ggatttcccc cgtagccctc tttcaccccc cccccccggc cattaccgaa gcggatgaaa      300

acaaacacta acgatggcgg cgccgggaag cgaccggctg ctgggcttaa ggcgggagtg      360

accgcttaac cagtgaggga agcactgaag agcgccagtc gacgtgggtg cgacaactcg      420

cggagtctta ggagcaaaac gtctggggcc tgcgagccag gacccttctg aagccttagg      480

tgtctatcgg cgacgtgtac ggtcactgca gctccggagc gcggaaccct cagccaggag      540

gcgcggctgg tcggtcccag gtcccggcct ccgtaatgag agcccggaac cactctttgt      600

gccgcagctt cgcaggtact aacttttgcg ggggataccc caagatctct cagcgccccc      660

gggtgggagg ctgtggattc ctataggcaa tggaaactga tctcaattcc caggacagaa      720

aggacctgga caagtttatt aaattttttg ccctcaagac tgtccaagtg attgtccagg      780

ctcggcttgg tgaaaagatt tgcactcgtt catcatcttc tccaacgggt tcagattggt      840

tcaacttagc aatcaaagac atcccagagg ttacacatga agcaaagaag gcactggcag      900

gacagctgcc tgcagtcggg aggtccatgt gtgtggagat ttcacttaag acttctgagg      960

gagattccat ggagctggaa atatggtgtc ttgaaatgaa tgaaaagtgt gataaagaaa     1020

tcaaagtttc ctacacggtg tacaacagac tgtcattgct gctgaagtcc cttcttgcta     1080

taactagggt gacaccagcc tataggctct ccaggaaaca agggcatgaa tatgtcatat     1140

tatacaggat atattttgga gaagttcagc tgagtggctt aggagaaggc ttccagacag     1200

ttcgtgttgg gacagtgggc acccctgtgg gcaccatcac tctttcttgt gcttacagaa     1260

ttaacttggc attcatgtct accaggcaat ttgagaggac cccacctatc atggggatta     1320

ttattgatca ctttgtggac cgtccctatc ccagctcctc tcccatgcac ccctgcaatt     1380

acagaactgc tggtgaggac actggagtaa tatacccgtc tgtagaagac tctcaagaag     1440

tgtgtaccac ctctttttcc acctccccac catcccagct gatggttcct gggaaggaag     1500

gtggggtacc ccttgctccc aaccagcctg tccatggtac ccaggctgac caggagagac     1560

tggcaacctg caccccttct gacagaaccc actgtgctgc cacaccctcc agtagtgagg     1620

atactgaaac cgtatcaaac agcagtgagg gacgggcctc ccctcacgat gtcttggaga     1680

ccatctttgt ccgaaaagtg ggggcttttg tcaacaaacc cattaaccag gtgaccctga     1740

cgagtttgga tatacccttt gccatgtttg ctcccaagaa tttggagctg gaggataccg     1800

atccaatggt gaatcctcca gattccccag agactgaatc tcctctccag ggcagcctgc     1860

actcagatgg ctccagcggg ggcagcagtg gcaataccca tgatgacttt gttatgatag     1920

actttaaacc agctttttct aaagatgaca ttcttccgat ggacctgggg accttctatc     1980

gggagtttca gaacccacct cagctgagca gcctctccat agatattgga gcacagtcca     2040

tggctgaaga cttggactca ttaccagaga agctggctgt gcatgagaag aatgtccgcg     2100

agtttgatgc ctttgtggaa accctgcagt aaaagtatcc ttgagtccca gcagcacccc     2160

ctttttgtgg ccccagggca taagcagcct cccatgcatc agctgctccc acccctcatc     2220

ctgctctgag ccaggtggaa gggaggctgg cttctcccat ggggacccag aagtccctac     2280

tcttggacct cctggagact ccgtggcggc agtcaagccc agtgcccagt tggagaagac     2340

tcacgtgctg gccttggaga tgggaagaac cttcgtacga aaaagccctc agcagggcca     2400

tctgtgtgcc ctgcccatca ccaactgctt cccaagggtg tcatcctgtt cctcctgctg     2460

ccggcctcct gcctgggcct gccttgcagc tggccccttc cctgcctgct gtcaccatcc     2520

actgtttgac attccagctg gtggccaaga gattggtgtg gagtcgcaga aagaggaagg     2580

agacagtgcc aggaggaaga aggaaggagt cccttagctc tcttcattgt cccctttact     2640

tcctgctatc ttcttctcct cttcttctct ctcttgcctc tatgcctgta tttctggcaa     2700

tatgacaggc ctgcctaccc aagatcagaa ctccaaaacc actcccaccc ctgaaggtcg     2760

ggagggtctg agcagccctg gtggctgcct gtgctcaggt cctcagctcc atgggaaata     2820

aaaatggcac cctgaatctc taggattttg tcacttggag tcacagcaaa gttctcttcc     2880

tcttgtcccc ccgttgctgc tccttggtta tagaacatgg taaatattta ttactttcag     2940

agaaaccaga tattttatag aggaaatatg tttgaggtga gttgtttttc acttggagaa     3000

ggcggagggc tcttcctggg acggagacct cctcctccgg aggttattga gaatccgggc     3060

tgctgctttg aggatcttcc caccatacag acagcgagat ccaagaagag ggctggccgg     3120

gggcaaagtc acctcccagt gtggctgcac tggaactgac taaaggcttt accttggata     3180

gttgcgtatt cctggtgaga gccttacatc tcccacagtt tctgcagagt gactgactcc     3240

attctggcag cccaggaagt cctgggtgct aaatgtgatg gccacatgta gtggttaggg     3300

gatgttgtgt gtgtccccca actgcctggg tacttgttcc tgatccctgg ggctgtcctg     3360

tggagctttt cctcctgctt gggcctagct accatctccc tctaatccca ggttctctac     3420

actgccctgg ggtttaccag ctggattggc ttctggttga gaaatcaaag ctgggcgtat     3480

gattgactta acccttcagg tattgttact tgaataagtc aagtgcctag cctcacccac     3540

ctatgatctg tcctttccca gcctcgctgg tagtcctggt caaggagatc taggtctact     3600

ccattcctcc tggcccacct ggggcattca ctggcagcag ctgtgcttca gtggagcagg     3660

tggttctcag ctgcttgtta gtatactgca tgtgacactg ttcccacata caaggctgac     3720

ttctgaggat tggagcaggc tctggcgggg accagagctc tgcgtgctgc tgctgccacc     3780

aagaagtgtt agcagaagca gtagcagcca actggccctc ctgactttgg cccagagcac     3840

atgcgtggct tgctgaaccc aggctcaggt ttatccccaa ggccccagct ttgagaaggg     3900

ggaaggcccc tggtaagtta ttgatgcccc catatttcag ctactgctct ctttccaagg     3960

ccttgcatgg aaaggcctag ccattgtctg aggcagcaat ctttggcatc tacaggtggc     4020

agcagccttt caccagggct ccatctgtga agagtctcag ccatgacttt gagctgagct     4080

tgggagaagt aaagcaactg ttaaggccag cccttgcccc tcagacctgc catgaaagga     4140

atgagcccta gactgactcc tgcagcaccc ccgggacagg ctgggaccag ctgtttgtct     4200

ccaggtgtca gagtccctcc tcctcctcca acctctccaa cctactttgt ttggaaatac     4260

cgagctacac ttcaaaatgt attcaaggga tttccaataa atttttttct gtactttaca     4320

gcctcctgtc ctgtaggttg tctgaagacc tcgtaacccc ttccccaccc ctgccccagt     4380

gcaggtctgg gaaaggggag agtggtgcgt tgtgaagcgc agaaagacct caagtgtctg     4440

ggcaagcctg ttttgagtcg ggtgtggcct cttaggggct gtataccctg gggtttcctg     4500

ggtcaggaaa cttcttagta tttctctttc cctggtcccc tatcaggggc ttgaatttga     4560

atattcagtt ggagaatgca tttaaaatac acccatagta aaatctccat aaaatgc        4617


<210> 3546
<211> 521
<212> DNA
<213> Homo sapiens

<400> 3546
gtttattact actgaaggaa gaacgtgagt agatcagaaa agggagctca ggtaccttcc       60

agagagtgag acccagcgcc cttgtctcgc acccagtagg ctttcatccc cgccatggcg      120

gagctgatcc agaagaagct acagggagaa gtggagaaat atcaacagct acagaaggac      180

ttaagtaaat ccatgtcggg gaggcagaaa cttgaagcac aactaacaga aaataatatc      240

gtgaaagagg aactggccct gctggatggg tccaacgtgg tctttaaact tctgggtccg      300

gtgctagtca aacaggagct gggggaggct cgggccacag tagggaagag gctggactat      360

atcacagctg aaattaagcg atacgaatcc cagcttcggg atcttgagcg gcagtcagag      420

caacagaggg agacccttgc tcagctgcag caggagttcc agcgggccca ggcagcaaag      480

gcaggggctc ctggcaaggc ctgaccccat ggtgggggga g                          521


<210> 3547
<211> 596
<212> DNA
<213> Homo sapiens

<400> 3547
agacaaagcc tgaatcctgg aaaaagccaa ctctttgaac aggaattaga gtgtgatcgg       60

ctcagttgac gtacagggaa acctttattt gaagccgata aatgacttgt cgtgggcgag      120

cccttcgggt gctattaata ctttcgggtc acagcggaga ctctggctgt tgttcagaaa      180

agaactacga atcccagaat gccctgttcc cccattttcc cctcgagaat ccaaggcatt      240

gtcctacata atggtagagg acgaactggc acttttcgat aaaagcataa atgaattttg      300

gaataaattc aaaagtacgg acacctcctg tcagatggcg ggactaagag atacctacaa      360

ggattccatc aaagcatttg cagaaaagct gtctgtgaaa ttaaaggaag aagaacgaat      420

ggttgagatg tttctggaat atcaaaatca gatcagcagg caaaataagc tcattcaaga      480

aaaaaaggat aacttgttaa aattgattgc tgaagtaaaa ggcaaaaagc aggaattgga      540

agtactgact gcaaatatcc aggatcttaa ggaagaatat tctaggaaga aggaaa          596


<210> 3548
<211> 620
<212> DNA
<213> Homo sapiens

<400> 3548
gttcttccgc accttcctca gggaggtccc gctggccaag gtctggctgt ccctcctgtc       60

ctctgccccc gcctcccttc caccggtccc cgacgtgccg ccagctccca gcccagcgtc      120

ccgcagggcg gtgcgggcag atgccgccga agcgtctagc gggaagggcg ccggcgcggc      180

tggagctttg taggcagcca atcccagaga agcagacggg atggctagtt cagcccggga      240

gcacctgctt tttgtgaggc gtcgaaatcc ccagatgcgg tacacattga gcccagagaa      300

cctccagagc cttgccgccc agagctccat gccagagaac atgaccctgc agcgggccaa      360

cagcgacacc gacctggtga cttctgagag ccgctccagc ttaactgcca gcatgtacga      420

gtacacgctg gggcaagccc agaacctcat tatcttctgg gacattaaag aggaggtgga      480

ccccagtgat tggattggac tttatcatat agatgagaat tctccagcca acttctggga      540

ttctaagaac aggggtgtga ctggaacaca aaaagggcaa attgtatgga gaattgagcc      600

tgggccctat ttcatggaac                                                  620


<210> 3549
<211> 691
<212> DNA
<213> Homo sapiens

<400> 3549
gctggaaatg gccttagggg tcacctaggg cctaatccat cgtttctctt gtgggggaac       60

tgagcctctg ggaagggtca cattgcgtta atgcagtgtg tgtcgcctct gtccctcccc      120

cttacacgtc tggcgtctcg tcagatacat gtcagctcct gggagaagct ttccctggcc      180

gctttgcaga agggcgtccc cttttagcct cttccacgtc aacctgctcc atttctttcg      240

tagcagttac cagtctctga aactaagtct gtttctgtct tagcccgcca agtatttatt      300

gtatacgtat ataggtgcca ccgtacaggc agtacttctc caggcaagta gtattaaaca      360

ccagccgccc tgggccaggc attgtactgt gggacccagt atgcattaag ggaagaatcc      420

aggttcaaaa tgagcctgtt tggaacaacc tcaggttttg gaaccagtgg gaccagcatg      480

tttggcagtg caactacaga caatcacaat cccatgaagg atattgaagt aacatcatct      540

cctgatgata gcattggttg tctgtctttt agcccaccaa ccttgccggg gaactttctt      600

attgcaggat catgggctaa tgatgttcgc tgctgggaag ttcaagacag tggacagacc      660

attccaaaag cccagcagat gcacactggg c                                     691


<210> 3550
<211> 1797
<212> DNA
<213> Homo sapiens

<400> 3550
gctgaggacg gggcggggcc tcgcgctaac ggtcgcgcgg ccgtcgcacc tgcacgaggc       60

tgtggcccga gcgtcctgtg gagaagccgc gaagcgcggg cgacccgggg gtcgggcggg      120

ccaggtccgc gaggccgcgg cggcagctgt gcaggcccgg ggagcagccg gccgggcgag      180

cctcggatta aaaaaatggc aaactccttt gcagcgagga ttttcactac cctttcagat      240

ctgcagacaa atatggctaa tctgaaagtt atcggtatag ttattgggaa aacagatgtc      300

aaaggctttc cagacagaaa aagtattgga tcagaaaggt acactttcag cttcaccatt      360

cgggattcac cagcacattt tgtaaatgca gcttcctggg gcaatgaaga ttacatcaag      420

tctctttctg acagctttag ggttggtgac tgtgtgataa ttgaaaatcc tctgatccaa      480

agaaaggaaa tagaaagaga agaaaaattc agccctgcaa ctcctagcaa ctgtaaactg      540

ttgctcagtg agaatcactc aacagtaaaa gtttgttcca gttatgaagt ggacacaaag      600

ttactttctt tgatacattt acctgttaaa gagtctcatg attattattc actgggtgac      660

attgttgcaa atggacacag tcttaatggg aggattatta acgtgcttgc agctgtgaaa      720

tcggttggag agccaaaata ctttacaact tcagaccgga gaaaaggcca gaggtgtgaa      780

gttagactct atgatgaaac agagtcgtct tttgcgatga catgttggga taatgaatcc      840

attctacttg cacagagctg gatgccacga gaaacagtaa tatttgcctc agatgtaaga      900

ataaattttg acaaatttcg gaactgcatg acagcaactg taatctcaaa aaccattatt      960

acaactaatc cagatatacc agaagctaac attctgctga attttatacg agaaaataaa     1020

gaaacgaatg ttctggatga tgaaattgac agttatttca aagaatccat aaatttaagt     1080

acaatagttg atgtctacac agttgaacaa ttaaagggaa aagctttgaa gaatgaagga     1140

aaagctgatc cttcctatgg catcctttat gcctacattt ccacactcaa cattgatgat     1200

gaaactacaa aagtagttcg aaatagatgt tccagctgtg gttatattgt aaatgaagca     1260

tctaacatgt gcacaacttg caacaaaaac tccttggact ttaaatctgt ctttctcagt     1320

ttccatgtgc tgattgatct gactgatcac acaggcaccc ttcattcctg tagtctcaca     1380

ggaagtgttg ctgaggagac tttgggctgc acgttcgttc tatcacacag agcaaggagt     1440

ggattgaaaa ttagtgtact ctcgtgcaag cttgcagatc ctactgaggc aagcagaaac     1500

ttgtctggac aaaaacatgt ttaaaacggt ctatcatttt gaactctgga aaagtataag     1560

agttttaact ccctttaaaa tggaatatta atttgaaaat tatggggaaa attgcatttt     1620

gtttacatgt ggtgaacatg tttctagaaa ttgttatggt ggaggtggtc tgggtgagtc     1680

tgaaggcctc tctcatctga cctcccttct tagaaggcct cctactgtct ttgccttgtc     1740

tcctcccaag ttggaaaatg tttacatgaa ttaataaaca gatttaatct tctacag        1797


<210> 3551
<211> 1059
<212> DNA
<213> Homo sapiens

<400> 3551
gacttccggt gctggaggag ggggccggcg gcgagggact ccaggaggac gcgtccaact       60

tcgagaccgg cgggggccgg ctccgctctt ccaacccctc catgtgtgaa gagggcggac      120

gacgcagcgg gggaagaaaa ataagctagt ctaggacaag tgtccaggcg acgtggaacc      180

cagtaaggga ataaagaaga ctggaaacgt ctctcccctc ccctatccca gtccctcacc      240

ctaatccgcg cgcaatagaa aaggcggaag cgcctgtcca cgatcagggc ggggcaaggg      300

gaagaaatct cgcgatagga gagcggtccg ggcgggggtg gcacctctcc ctcctcctgg      360

cgttagttcc ggtcgcagag gagacaccgc cgcagttgcc gggtgtcttt tatgaataat      420

caaaagcagc aaaagccaac gctatcaggc cagcgtttta aaactagaaa aagagatgaa      480

aaagagaggt ttgaccctac tcagtttcaa gactgtatta ttcaaggctt aactgaaacc      540

ggtactgatt tggaagcagt agctaagttt cttgatgctt ctggagcaaa acttgattac      600

cgtcgatatg cagaaacact ctttgacatt ctggtggctg gtggaatgct ggccccaggt      660

ggtacactgg cagatgacat gatgcgtaca gatgtctgcg tgtttgcagc ccaagaagat      720

ctagagacca tgcaagcatt tgctcaggtt tttaacaagt taatcaggcg ctacaaatac      780

ctggagaaag gttttgaaga tgaagtaaaa aagctgctgc tgttcttgaa gggtttttca      840

gagtcggaga ggaacaagct agctatgttg actggtgttc ttctggctaa tggaacactt      900

aatgcatcca ttcttaatag cctttataat gaaaatttgg ttaaagaagg agtttcagca      960

gcttttgctg tgaagctctt taaatcatgg ataaatgaaa aagatatcaa tgcagtagct     1020

gcaagtcttc ggaaagtcag catggataac agactgatg                            1059


<210> 3552
<211> 2913
<212> DNA
<213> Homo sapiens

<400> 3552
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc       60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccaggcg acacaaagtt      120

atcattgttg ggctggataa tgcagggaaa actaccattc tttaccaatt ttctatgaat      180

gaagttgtac atacatctcc tacaatagga agtaatgtag aagagatagt gattaataat      240

acacgtttcc taatgtggga tattggtggc caagaatctc ttcgttcttc ctggaacact      300

tactatacta acacagagtt tgtaatagtt gttgtggaca gtacagacag agagaggatt      360

tctgtaacta gagaagaact ctataaaatg ttagcgcatg aggacctaag aaaagctgga      420

ttgctgattt ttgctaataa acaagatgtt aaagaatgca tgactgtagc agaaatctcc      480

cagtttttga agctaacttc tattaaagat caccagtggc atatccaggc atgctgtgct      540

ctaactggcg agggattgtg ccaaggactt gaatggatga tgtcacgact taagattaga      600

tgatctctac tgacctcttc tcatagattt tgtataaatg aagtgctgga ctttacctga      660

aagctgcaaa aattaatggt ttagatatat ttataataaa ctgatttaaa ctttttctat      720

aagaagaaaa attaagacca cttatttgaa aacaaagatg aagtctcacc ttccagtttg      780

ctttctcatt agttttttcc aaagtaagtt attgaagctg tgattgacat ttttctcata      840

atgaatcctc tcaggacatt gtgtagccta tggtaagtac aaagggagag gaagacattt      900

tgaattttaa gagctttatt atcagtttaa ccctccctag ttgaatgtta ttttcttctt      960

gttccattaa gtcagaatac aaatcagcac agatattcga atgtttccaa tattttaaaa     1020

tgtaatgtta cttatgaaaa gtattttgct taaggttgtg tgtgtattgt gtatatacct     1080

caagttcaag ttaatggcat tgatttatgt tccagacaaa aataacacaa ataataatat     1140

ccttcgttat aaccacaatg agataagtat tggcattagt gttcagtgcc attttatact     1200

ttctctctgt gttctctgta ttgtactaac caacctccca aatcgctgag ctgcttgttt     1260

aaaaaaaaaa aaaaggaaaa ggaaaaagca tgacattgtg tatcgatttt ttgttgttga     1320

ccaaaatcac acacatggaa acatgtaatt caacagagtg ggaaagctag cagattcttg     1380

gcttagtatt actaataggc aggattgtac aatgagcaac tatcagatta ttcctttcag     1440

tggttcttat ggcatctaaa ttactgaata aattattaat ccattaatca gtgaatcaaa     1500

ttatgattac aattatcaaa tgaatgctca gcattaattg aaaactgttt tgtgaaacat     1560

gtctacccag aaaagtagca ttctataaat actattaaac aacttagcta tattattttt     1620

aagtattaaa ttatatgtca agcagttaaa gtgaatttca gagtaaaagt aaggcatgtt     1680

tctgagcaac attgataatt tcttaatttg caaatttctt cttattttgg tacttggaat     1740

atagtgtgag attttttatt tctaaatttt gttgtatctt ctattacata aatgcattga     1800

caattataaa atgcaagtgt tttttgaatg attttaagaa tttggcttaa aaattgattg     1860

atacaacgta ttatttgtac taagaagtaa cttgacccaa aacacctttt atgtttgctt     1920

agggtatatt ttttcagtgt ctgaaagtca aaggtattcc tgtcacaact gtaaacaaac     1980

ttatcctaaa tgtgttaaaa catattcttg ggtactctat ttatgtatct ttcatgcctt     2040

gaaaatctga aggttaatcc aaactcacat gttttagcat atttgagaaa aaaaaactac     2100

cttcaatatc agccttttaa atttcatgaa gattttggtg aggaataata gtatatagtt     2160

taagtattga caaaactttg aaagtttctt tctttaaaat gggaaatact caatatctaa     2220

atccaggtca ggcatgggat atcagtattt aacattggat gttttatgtt ttatatttat     2280

aatgttcaaa atgcaagcat aacatttaat atttgtccac atggttttac aaaagtaaat     2340

cttaaattac taagcttttc ccatatgttc tcgtactttc tcaaatccct ataaagaatt     2400

acttgttatc tattaaaaat ctcctttacc caaatctgta ttatggtttc gccagacaaa     2460

tattatgtga tgtagcccag aaaatccaca ccttttgtcc tttttatgtt ttaatttgaa     2520

taatcatgtg cttagtccct tggattactg ccacatcagt ttaacacgat atcagcacat     2580

tcccttgtca tcatcaaggt gttggctcag atttattctt aattggatgt ttaaagcatg     2640

tactaccttg ttacagttgg tttagtgtag tggattattg acatgacatc atgagaagat     2700

gtgtaatttt ataccacatt tataaaacat gattttgttt tctacccttc aaggtaaaca     2760

ttaaaaataa ggtggtactt gtgtacttgt acataaaacc aaaattatag ttgggaaaaa     2820

aataaattta tatatgaaaa tgtcaaaatc attttaaaag tattattttc aaataaaatg     2880

gagaagctgg tgaaaagtca tattggcaat ttt                                  2913


<210> 3553
<211> 445
<212> DNA
<213> Homo sapiens

<400> 3553
gccatccaca tcctcgatgt ccttgtgctg aatggcaccg acgttcggga gcagcacttt       60

aaccagcgaa ttcagcttgc cgagaaattt gtgaaagccg tttccaagcc tagtcggccc      120

gacatgaatc ccatcagggt gaaggaggtg tacagactgg aagagatgga gaagattttt      180

gtcaggttgg agatgaagat catcaagggc tccagtggca ccccaaagct cagctacaca      240

gggcgtgatg accggcactt tgtacccatg ggcctctaca tcgtcaggac agtgaatgag      300

ccctggacta tgggattcag caaaagcttc aagaagaagt tcttctacaa caagaaaacc      360

aaggactcta cttttgacct cccttactac cctttccctt cctttttctt ccctaatagg      420

aggtacaatc tgcttttgtt tgtcg                                            445


<210> 3554
<211> 545
<212> DNA
<213> Homo sapiens

<400> 3554
acatccggga ccctcatccg gggctctcac ccacatccgg gaccctcatg cctgggcgga       60

ggaggggggg ccctcattcg ggaccctgca ctccgtcgcc ggaagtgcca ccgagaagcg      120

ccggcctcgg ggctgtctac agcggcccgg gagaggctgt ggtggccccg agcgcgagtg      180

tgtaggtgac aggacagcgg ccaggcccgc ccctcccctc gtgatggtca ttgtcctcca      240

gagcagtgat ggaggaaata ccagcccagg aagcagcagg gtcaccaagg gtccagtttc      300

agtctttgga gacccagtct gagtgtctgt ccccagagcc tcagtttgtg caggacaccg      360

acatggaaca gggactcact gggggcatac ttctccgcct tcccaccacc cggattcata      420

gtgtgaattc ctgcccggcc ctgagtcata cccaggcaag tgctttctct ggagaaacac      480

ttgccgtcct tacagcagga atctccaaga gatggcccaa gtatcggctt cccatcgata      540

ttgct                                                                  545


<210> 3555
<211> 5544
<212> DNA
<213> Homo sapiens

<400> 3555
atgcagctcc gagcgagcga gcggcgccca gcccagcgcc tcggccgaac ccctccgcag       60

caggctgcct gctgtttccc ggggagatca tgaaacgagg tcgccttccc agcagcagtg      120

aggattctga cgacaatggc agcctgtcaa ctacttggtc ccagaattcc cgatcccagc      180

ataggagaag ctcctgctcc agacatgaag atcgaaagcc ttcagaggtg tttaggacag      240

acctgatcac tgccatgaag ttgcatgact cctaccagct gaatccggat gagtactatg      300

tgttggcaga tccctggaga caggaatggg agaaaggggt ccaggtgcct gtgagcccgg      360

ggaccatccc tcagcctgtg gccaggccca agaagtacat cgtgtcatca ggctctgagc      420

ctcccgagtt gggctatgtg gacatccgga cgctggctga cagcgtgtgt cgctatgacc      480

tcaatgacat ggatgctgca tggctggaac tgaccaatga agaatttaag gagatgggaa      540

tgcctgaact agatgaatac accatggaga gggtcctaga ggaatttgag cagcgatgct      600

acgacaatat gaatcatgcc atagagactg aggaaggcct ggggatcgaa tatgatgaag      660

atgttgtctg tgatgtctgc cagtctcctg atggtgagga cggcaatgag atggtgttct      720

gtgacaaatg caacatctgt gtgcaccagg cctgttatgg aatcctcaag gtaccagagg      780

gcagctggct gtgccggaca tgtgccctgg gggttcagcc aaaatgtctg ctgtgtccga      840

agaagggtgg agctatgaag cccacccgta gcggaaccaa gtgggtccac gttagctgtg      900

ctctgtggat ccctgaggtg agcattggca gcccagagaa gatggagccc atcaccaagg      960

tgtcacacat tcccagcagc cggtgggcgc tagtgtgcag cctctgcaat gagaagtttg     1020

gggcctctat acagtgctct gtgaagaact gccgcacagc cttccatgtg acctgtgctt     1080

ttgaccgggg cctggagatg aagaccatct tagcagagaa tgatgaagtc aagttcaagt     1140

cctattgccc aaagcacagc tcacatagga aacccgagga gagtcttggc aagggggctg     1200

cacaggagaa tggggcccct gagtgttccc cccggaatcc gctggagccc tttgccagcc     1260

ttgagcagaa ccgggaggag gcccaccggg tgagtgtccg taagcagaag ctgcagcagt     1320

tggaggatga gttctacacc ttcgtcaacc tgctggatgt tgccagggct ctgcggctgc     1380

ctgaggaagt agtggatttc ctgtaccagt actggaagtt gaagaggaag gtcaacttca     1440

acaagcccct gatcacccca aagaaagatg aagaggacaa tctagccaag cgggagcagg     1500

atgtcttatt taggaggctg cagctgttca cgcacctgcg gcaggacctg gagagggttc     1560

ggaacctcac ttacatggtg acccgcaggg aaaagattaa acggtctgtg tgcaaagtcc     1620

aggaacagat attcaatctt tacactaagc ttttggagca agaaagagtt tcaggtgtgc     1680

cttcttcctg ctcctcctcc tcactggaaa acatgctttt gtttaacagt ccttctgttg     1740

gccctgatgc tcccaagata gaggacttga agtggcattc tgcattcttc agaaaacaaa     1800

tgggtacttc cttggttcat tcgctgaaaa agccccataa gcgagatcct ttgcagaata     1860

gccctggaag tgaaggcaaa accctgctga agcagccaga cctgtgtggt agaagggagg     1920

ggatggtggt cccagagagc tttttgggtt tagaaaagac ctttgcagaa gcacgtctca     1980

tatcagcaca acagaaaaat ggtgtggtga tgccagacca tgggaaaaga agagacaatc     2040

gttttcattg tgatctcatt aaaggagact taaaggacaa atcttttaaa cagagtcaca     2100

agcctctcag gtccacagat gtgtcccaga ggcatctgga caacacaaga gctgccacct     2160

cccctggagt ggggcagtca gcacctggca caaggaagga gatagtgccc aagtgcaatg     2220

gctccctaat caaagtaaac tataatcaga ctgcagtcaa agtgcctaca acacctgcca     2280

gcccagtgaa aaactgggga ggattccgga ttccaaagaa gggggaacgg cagcagcagg     2340

gagaggccca cgatggggcc tgccaccagc actcagacta cccatatttg ggcttaggcc     2400

gagttccagc caaggaaagg gcaaaaagca aattaaaatc cgacaatgag aatgacgggt     2460

atgtccccga tgtggaaatg agtgactcag agagtgaggc atcagaaaag aaatgtatac     2520

acaccagcag cactatcagc agaaggacag acattatcag gagaagcatc ttggcttctt     2580

gatgcaacag agatgatgcg gaagcccttt gggctcgtca ttgggtttgc tagaggagag     2640

ctctgatgtg ggggagaagc agaaacccat taatcctgag ctacacaaac acatttactt     2700

gcaattcaga ttaatttttt tccagagtca tttttaaatc atttttgtga gaagtttgtg     2760

ttatttgcaa cttgttgagg aaacagaaga gtagattgta accataagac actgctaaga     2820

ctagaacccg aactgaacac taaaataaaa atgaaatgtt ttaaagaagg caaggcttaa     2880

ataagcctca tgaattttta tagccctctg cattcttccc aaagcacaaa ctcatggtta     2940

cctgaatata gggaaccaga tatggttctt gagaaaccct catggtacca ttcacagccc     3000

ataaagttta ttttctagga ctgtggtaga tcttgaaatc atatttatat ttggccctca     3060

aggctatttt tgttgcatta tagcatatag gcagcagctc tgaagcttca gtaacactaa     3120

gaaatttatg tgtaaatata gcagtcaggg aagagaattt taaaaaaggt cattattgaa     3180

gaagctgagg ggacagggta gagctgctgc aatatggaga tttagggtaa tatggcaagg     3240

tcctgctgct tgaagcctgt gagtgggttg tggatatggg actggtggag agtgagactg     3300

ttaggaaagt tgtatctatg aataagggca gttgaagtag aatttttacc agtccacttg     3360

accttcttct tccctaacca ctggctcttg agccagcttg ggatttccct ggccattgcc     3420

aatacctggc catctggctt ccaatagtac agtggctact caagttcaag cgaagaactt     3480

ccagactctg gtgactgtta cttcccagag ccaaccacta gtgcatatgt tagggaatct     3540

gggcttccaa catgaatgga ttccttaaga aaaaggaaaa aaaaaaaaaa aagaaaaaaa     3600

gaaaaaaaaa agaaaaaaga aaaaaagaga aaaaagcgaa ataggttata ttttaaaaac     3660

aatagaaagg caataagttg cgataagctc ttactattga ccaaggttat acaggaaaga     3720

gactgaagtg tacccttgaa taggttttct gtagtcagag ttctaaactc taatttgtaa     3780

cttggacttt ctaattgcaa atggcaataa ctattaagtt atcagcaata ataaatttag     3840

cattaaattt gagtacaatg ttttgttttt gcactcccca tagtgcgtat gtattaagac     3900

agtggatagt gtttaggtcc tgttaatttt ctttggaatt caatgtggtt gtgaatcaaa     3960

cttaaggaag gaacgtttaa atagcaatga gatacagaat tatgggcctt tggaacaagc     4020

ccgacttccc ctaaattctc cttagtttgt taataccagt attcagattc ctgattcatt     4080

tatacatctg tttccatatg gcagggacat tatgatactt aatgaataat gctttgagga     4140

gttctgcagt taactttcaa gtcttccaga tgattgtcaa caacaaaaaa ggcttattga     4200

atcccatctt gctatgcaag ttttatcaga tgatcaaata gtagatctga tacatcccca     4260

ttgtatgtac gacattttca aaccaagtct taacttttca aggacatttt agtagctaat     4320

tcaggggagg gggaagaatg atgcaggttt ttagattgac tgactatttt tgagttatgg     4380

ggctcatttt gaaagactgc tgtccagatc agcttgttgc tgcagataat agaaggttct     4440

tatgaatcca agttgtatat tcacttgtag gataatttaa aaattagatt ttttttgcat     4500

atgagcaaaa accttttgct ggatacagga gaaggttgga ctttatctac agttatcttt     4560

tgattacagc aacagctctg ggtgagagta gaatttatag agggataatt tgtcaagcca     4620

tagaaagaaa atctaaatta atctagtaag tgtatgacct ctcaccattt taagaggtat     4680

cagattcatt tgcactatta ggaatgctag ttttgtgcaa aaataatgcc ttacctgttt     4740

tttccccaca tttaggttga aaagctttca aatgttccaa gttatgctga accaaaaaaa     4800

acaaaacaaa aacaaaacaa aaaatattaa aaaaaaccca cacaaaaaca aaacacacaa     4860

aaataaaaag cccacacttt ttattcctgc ttcgaaatgc aaatggatag agcacggttt     4920

ctctgacagt ataatgatag ctttgtgagt tagtttcatg tcatgctggg aactctctat     4980

gaggtggcca taagcagcaa ccagcccaaa cacccacttg cgttctatta gtatggaacc     5040

atttgcattt gtttttttta agctttatct ttccttgtgc atcctgacca agaaatatct     5100

ttgattatga ttaatgtatt atgtcaaaat gtaggctagt taaacttttg taaagttgcc     5160

tggaatgtca tttgttaggt tataaacaca agatctaaat gaagggtttt atgtgttgtg     5220

tacaaatctt attttgaaat ggacaaactt gtcattacat ttgtaacctt gtacagagga     5280

tttttcacta tgtgcctagc ttggtgtcca ttcagctaaa attgaaaaaa aaaaaaaggt     5340

gcatgaagag ttaaaaatca aattaaagta tatgtagaga tgactatttt atattacatg     5400

acccaatcct gtatttattt ctaccccctt tttgaaagta tttataaaac tagttgagga     5460

cagctgtatt tttttgttga actatttagt agaattgtgc ctttttgtct gtatgtgaat     5520

aaatgctgta cattttgcaa taca                                            5544


<210> 3556
<211> 603
<212> DNA
<213> Homo sapiens

<400> 3556
gaaaccagac gtgcagtggg gctgacccct gtgccccacc ccagagtcat gccagcgtgg       60

gtggtggggc attctctggg atgaatgatc tggatcccat agccatctgt gtcctgtttg      120

aggaatggga ccctcaaaca gagaacagcc aagatgctca agcagtctgc agatctccag      180

gggagcccac cagcctagtc aacatggcct cggaagacat tgccaagctg gcagagacac      240

ttgccaagac tcaggtggcc gggggacagc tgagtttcaa aggcaagagc ctcaaactca      300

acactgcaga agatgctaaa gatgtgatta aagagattga agactttgac agcttggagg      360

ctctgcgtct ggaaggcaac acagtgggcg tggaagcagc cagggtcatc gccaaggcct      420

tagagaagaa gtcggagttg aagcgctgcc actggagtga catgttcacg ggaaggctgc      480

ggaccgagat cccaccagcc ctgatctcac taggggaagg actcatcaca gctggggctc      540

agctggtgga gctggactta agcgacaacg cattcgggcc cgacggtgtg caaggcttcg      600

agg                                                                    603


<210> 3557
<211> 442
<212> DNA
<213> Homo sapiens

<400> 3557
gtaggctgcg ggcagcgagg agcggctggc gctcgaggcg gcggacggca ccatgtcccc       60

ggggagcggg gtgaagagcg agtacatgaa gcgctaccag gagccgcgct gggaggagta      120

cgggccgtgc taccgcgagc tgctgcacta ccgcctaggc cgccggctgc tggagcaggc      180

gcacgcgccc tggctctggg acgactgggg cccggccggc tcctcggagg actcggcgtc      240

gtcagagtcg tcgggcgccg ggggccccgc accccggtgc gccccgccct cgcccccgcc      300

gcccgtagag ccggcgaccc aggaggaggc ggaacggcgg gcgcgcgggg ccccggagga      360

gcaggacgcg gaggccgggg acgcggaggc cgaggacgcg gaggacgcgg ctctgccagg      420

gaatgcctgg ctgcgcacct ag                                               442


<210> 3558
<211> 740
<212> DNA
<213> Homo sapiens

<400> 3558
gggtttatta ctactgaagg aagaacgtga gtaggttagg atttcggttg agaggcttgg       60

ggtcttgcgt ttcgcccacc atctcctggg gacagggtgg agtcgatatc cgggacgggg      120

gggaggttgc ggtgcccctc agggctacct ctcaagagtg ctatcatttc cgcaggccag      180

atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac      240

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      300

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      360

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      420

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      480

ggccacagta gggaagaggc tggactatat cacagctgaa attaagcgat acgaatccca      540

gcttcgggat cttgagcggc agtcagagca acagagggag acccttgctc agctgcagca      600

ggagttccag cgggcccagg cagcaaaggc aggggctcct ggcaaggcct gaccccatgg      660

tggggggagg ggaggggagg ggagggaatg aggcagctct aggatctata ctgtagctaa      720

taaaatgtaa aaacacctgg                                                  740


<210> 3559
<211> 816
<212> DNA
<213> Homo sapiens

<400> 3559
gcaaattatc gcatccctga gcttaggatc cccctttagt ttcacatatg cccccacccc       60

cgtttccact ttgatggcgg cttccaagga gcatccctta gtaagaaccg tcgcaaatat      120

cgtgatttgg atccaccaag gcttggggcg agccgtcgaa tgtgtgtggt aggggagcgg      180

gctgatgtta gcacgtggtc ttgttaggcc ttgaatgggg gaataggagg cctgtgttca      240

cgattagttt ccaccaccta ccaacttgga acctttacat ctctccaagc ctgagtttcc      300

ttatctgtga gacagctgcg aataccggtt tccagagagt agttaagaac ccttgtgaac      360

accttcttca gcttccttcg acgcaaaaca gactttttca ttggaggaga agaagggatg      420

gcagagaagc ttatcacaca gactttcagc caccacaatc agctggcaca gaagacccgg      480

cgggagaaga gagcccggca ggaggccgag cggcgggaga aggcggagcg ggcggccaga      540

ctggccaagg aagccaagtc agagacctca gggccccaga tcaaggagct aactgatgaa      600

gaggcagaga ggctgcagct agagattgac cagaaaaagg atgcagagaa tcatgaggcc      660

cagctcaaga acggcagcct tgactcccca gggaagcagg atactgagga agatgaggag      720

gaagatgaga aggacaaagg aaaactgaag cccaacctag gcaacggggc agacctgccc      780

aattaccgct ggacccagac cctgtcggag ctggac                                816


<210> 3560
<211> 2707
<212> DNA
<213> Homo sapiens

<400> 3560
acagccaggc agccccgcgt ggggagtgca ggtggtttcg gttgcggcag tcgcgtcccg       60

ggagcgtcgc tgcctggtga acgctgggtc gctcatctct gaaacccagg cgaaggaggg      120

ctcgacgtcg cgggagtcct ttcaacctga ccgcggctta cggtcttcgg agctaatgtt      180

cattggtccc acaaaggggt cccacgtcgc gtccaggaca tagaggccgt gaggcaggga      240

gccagaggtc gtctggactc ttccgtacta gtcagttttc gaactagagg gggctttggg      300

atcaccagtc ggagcccttc gtgttacagc tagaatgggt actaggaaaa aagttcatgc      360

atttgtccgt gtcaaaccca ccgatgactt tgctcatgaa atgatcagat acggagatga      420

caaaagaagc attgatattc acttaaaaaa agacattcgg agaggagttg tcaataacca      480

acagacagac tggtcgttta agttggatgg agttcttcac gatgcctccc aggacttggt      540

ttatgagaca gttgcaaagg atgtggtttc tcaggccctc gatggctata atggcaccat      600

catgtgttat gggcagacgg gagctggcaa gacatacacc atgatggggg caactgagaa      660

ttacaagcac cgggggatcc tccctcgtgc cctgcagcag gtttttagga tgatcgaaga      720

acgccccaca catgccatca ctgtgcgtgt ttcctacttg gaaatctata atgagagcct      780

gtttgatctc ctgtccactc tgccctatgt tggaccctca gtcacaccaa tgaccatcgt      840

ggaaaaccct caaggagtct tcattaaggg cttgtcagtt cacctcacaa gtcaggagga      900

ggatgcattc agcctccttt ttgagggtga gaccaacagg attatagcct cccacactat      960

gaacaaaaac tcttccagat cacactgcat tttcaccatc tacttagagg cccattcccg     1020

gaccttatca gaggaaaagt acatcacttc caaaattaac ttggtggatc tggcaggctc     1080

agagaggctg gggaagtctg ggtctgaggg ccaagtcctg aaggaagcca cctacatcaa     1140

caaatcgctc tcattcctgg agcaggccat cattgccctt ggggaccaga agcgggacca     1200

catccccttt cggcagtgca agctcaccca cgctctgaag gactcgttag ggggaaactg     1260

caatatggtc ctcgtgacaa acatctatgg agaagctgcc cagttagaag aaacgctatc     1320

ttcactgaga tttgccagca ggatgaagct agtcaccact gagcctgcca tcaatgaaaa     1380

gtatgatgct gagagaatgg tcaagaacct ggagaaggaa ctagcactac tcaagcagga     1440

gctggctatc catgacagcc tgaccaaccg cacctttgtg acctatgacc ccatggatga     1500

aatccagatt gctgagatca actcccaggt gcggaggtac ctggagggga cactggacga     1560

gatcgacata atcagcctta gacagatcaa ggaggtgttc aaccagttcc gggtggttct     1620

gagccaacag gaacaggaag tggagtccac tttgcgcagg aagtacaccc tcattgacag     1680

gaatgacttt gcagccattt ctgctatcca gaaggcgggg cttgtggatg ttgatggcca     1740

cctagtgggt gagcctgaag gacaaaactt tggactcgga gtcgcccctt tctctaccaa     1800

acctgggaag aaagccaagt ccaagaagac attcaaagag ccactcagct ccttggcaag     1860

aaaggaaggt gccagcagcc ctgtgaatgg gaaggacttg gattacgttt ccacctccaa     1920

gacccagctg gtcccatcct ccaaagatgg ggatgtcaaa gacatgcttt cgcgggaccg     1980

ggaaacttcc agcattgagc cccttccctc agactccccg aaggaggaat tacgcccaat     2040

taggcccgac accccaccct ccaaaccagt ggcctttgag gagtttaaga atgagcaagg     2100

tagtgagatc aaccgaattt tcaaagaaaa caaatccatc ttgaatgaac ggaggaaaag     2160

ggccagcgag accacacagc acatcaatgc catcaagcgg gagattgatg tgaccaagga     2220

ggccctgaat ttccagaagt cactacggga gaagcaaggc aagtacgaaa acaaggggct     2280

gatgatcatc gatgaggaag aattcctgct gatcctcaag ctcaaagacc tcaagaagca     2340

gtaccgcagc gagtaccagg acctgcgtga cctcagggct gagatccagt attgccagca     2400

cctagtggat cagtgtcgcc accgcctgct catggaattt gacatctggt acaatgagtc     2460

ctttgtcatc cctgaggaca tgcagatggc actgaagcca ggcggcagca tccggccagg     2520

catggtccct gtgaacagga ttgtgtctct gggagaagat gaccaggaca aattcagcca     2580

gctgcagcag agggtgcttc ctgagggccc tgattccatc tccttctaca atgccaaagt     2640

caagatagag cagaagcata attacttgaa aaccatgatg ggcctccagc aggcacatag     2700

aaaatag                                                               2707


<210> 3561
<211> 1473
<212> DNA
<213> Homo sapiens

<400> 3561
accaccgctg cggccgccgc ctccgccgct gctttcgctg gagggcgggc ggatgtacgg       60

ggcgcctggg gccccggcgc aaagcgcctc agtgactgtg gtccgctcgt tgcggcggcc      120

gccaccgcag gcgacagggg tgtcttttat gaataatcaa aagcagcaaa agccaacgct      180

atcaggccag cgttttaaaa ctagaaaaag agatgaaaaa gagaggtttg accctactca      240

gtttcaagac tgtattattc aaggcttaac tgaaaccggt actgatttgg aagcagtagc      300

taagtttctt gatgcttctg gagcaaaact tgattaccgt cgatatgcag aaacactctt      360

tgacattctg gtggctggtg gaatgctggc cccaggtggt acactggcag atgacatgat      420

gcgtacagat gtctgcgtgt ttgcagccca agaagatcta gagaccatgc aagcatttgc      480

tcaggttttt aacaagttaa tcaggcgcta caaatacctg gagaaaggtt ttgaagatga      540

agtaaaaaag ctgctgctgt tcttgaaggg tttttcagag tcggagagga acaagctagc      600

tatgttgact ggtgttcttc tggctaatgg aacacttaat gcatccattc ttaatagcct      660

ttataatgaa aatttggtta aagaaggagt ttcagcagct tttgctgtga agctctttaa      720

atcatggata aatgaaaaag atatcaatgc agtagctgca agtcttcgga aagtcagcat      780

ggataacaga ctgatggaac tctttcctgc caataagcaa agtgttgaac acttcacaaa      840

atattttact gaggcaggct tgaaagagct ttcagaatat gttcggaatc agcaaaccat      900

cggagctcgt aaggagctcc agaaagaact tcaagaacag atgtcccgtg gtgatccatt      960

taaggatata attttatatg tcaaggagga gatgaaaaaa aacaacatcc cagagccagt     1020

tgtcatcgga atagtctggt caagtgtaat gagcactgtg gaatggaaca aaaaagagga     1080

gcttgtagca gagcaagcca tcaagcactt gaagcaatac agccctctac ttgctgcctt     1140

tactactcaa ggtcagtctg agctgactct gttactgaag attcaggagt attgctatga     1200

caacattcat ttcatgaaag ccttccagaa aatagtggtg cttttttata aagctgaagt     1260

cctgagcgag gagcccattt tgaagtggta taaagatgca catgttgcaa aggggaagag     1320

tgttttcctt gagcaaatga aaaagtttgt agaatggctc aaaaatgctg aagaagaatc     1380

tgaatctgaa gctgaagaag gtgactgaat tttgaaacta caccctcagt aaagcaaaca     1440

ggagttgtag ataaaatgtc atgtctcatg tgt                                  1473


<210> 3562
<211> 1421
<212> DNA
<213> Homo sapiens

<400> 3562
aatcggctag gagcagcgag cggcgcggct gaggcgcggc ggccccgtgg agcagcgcag       60

tatggcgggc ggggcccggg aggtgctcac actgcagttg ggacattttg ccggtttcgt      120

gggcgcgcac tggtggaacc agcaggatgc tgcgctgggc cgagcgaccg attccaagga      180

gcccccggga gagctgtgcc ccgacgtcct gtatcgtacg ggccggacgc tgcacggcca      240

ggagacctac acgccgcgac tcatcctcat ggatctgaag ggtagtttga gctccctaaa      300

agaggaaggt ggactctaca gggacaaaca gttggatgct gcaatagcat ggcaggggaa      360

gctcaccaca cacaaagagg aactctatcc caagaaccct tatctccaag actttctgag      420

tgcagaggga gtgctgagta gtgatggtgt ctggagggtc aaatccattc ccaatggcaa      480

aggttcctca ccactcccca ccgctacaac tccaaaacca cttatcccta cagaggccag      540

catcagggtc tggtcagact tcctcagagt ccatctccat ccccggagca tctgtatgat      600

tcagaagtac aaccacgatg gggaagcagg tcggctggag gcttttggcc aaggggaaag      660

tgtcctaaag gaacccaagt accaggaaga gctggaggac aggctgcatt tctacgtgga      720

ggaatgtgac tacttgcagg tagtggcgtg gcaatgtgca ctccagggtg gaagctcttc      780

tcatcctgct aactatcttt cgtcactcac ccccgcccag ggcttccaga tcctgtgtga      840

cctgcacgat ggcttctctg gggtaggcgc gaaggcggca gagctgctac aagatgaata      900

ttcagggcgg ggaataataa cttggggcct gctacctggt ccctaccatc gtggggtgag      960

tggaacttgg aggagtaaac attcgaatcc cattgggaga gtggcttaat gcaaactggt     1020

ttttttcttt acgaggaggc ccagagaaac atctatcgtc tattaaacac agcttttggt     1080

ctcgtgcacc tgactgctca cagctctcgt ctgccccttg tccttgggtg ggagcctggg     1140

cctgcgacct gagccacctg tcaacttccc ttacctgcat tatgatgtaa gtctcggtgc     1200

tcttgttctg actgcggcag gctacagggc ctcctcatgc tcccagtcag tcgctgtctg     1260

tactggctct gttcctgagg cccgagcttg aactcagctg tgatgtggcc tctcagatca     1320

cactgtccta tgcttgtcca gcctggggtc aaacataccc ctgattcatc ccctgggtct     1380

ctctggtgtt aacattctgc ctccacacat tcttttccag g                         1421


<210> 3563
<211> 282
<212> DNA
<213> Homo sapiens

<400> 3563
tgcaccagct cctgcacgcc ctcgtgctgc cagcagtcta gctgccagcc ggcttgctgc       60

acctcctccc cctgccagca ggcctgctgc gtgcccgtct gctgcaagac tgtctgctgc      120

aagccttcta gctgccagcc agcttgctgc atctcctccc cgtgtcaaca gtcctgctgt      180

gtgcccgtct gctgcaagcc catctgctgt gtgcctccag cttgctgcac cacctcctgc      240

tgcagaccct cctcctccgt gtccctcctc tgccgccctg tg                         282


<210> 3564
<211> 1513
<212> DNA
<213> Homo sapiens

<400> 3564
agctacagca gcggcgcgga gactgcgggg cgggccatgg cggcgaacct gagccggaac       60

gggccagcgc tgcaagaggc ctacgtgcgg gtggtcaccg agaagtcccc gaccgactgg      120

gctctcttta cctatgaagg caacagcaat gacatccgcg tggctggcac aggggagggt      180

ggcctggagg agatggtgga ggagctcaac agcgggaagg tgatgtacgc cttctgcaga      240

gtgaaggacc ccaactctgg actgcccaaa tttgtcctca tcaactgggg ggcccatgtg      300

accatcaacg cacgggccga ggaggatgtg gagcctgagt gcatcatgga gaaggtggcc      360

aaggcttcag gtgccaacta cagctttcac aaggagagtg gccgcttcca ggacgtggga      420

ccccaggccc cagtgggctc tgtgtaccag aagaccaatg ccgtgtctga gattaaaagg      480

gttggtaaag acagcttctg ggccaaagca gagaaggagg aggagaaccg tcggctggag      540

gaaaagcggc gggccgagga ggcacagcgg cagctggagc aggagcgccg ggagcgtgag      600

ctgcgtgagg ctgcacgccg ggagcagcgc tatcaggagc agggtggcga ggccagcccc      660

cagagcagga cgtgggagca gcagcaagaa gtggtttcaa ggaaccgaaa tgagcaggag      720

tctgccgtgc acccgaggga gattttcaag cagaaggaga gggccatgtc caccacctcc      780

atctccagtc ctcagcctgg caagctgagg agccccttcc tgcagaagca gctcacccaa      840

ccagagaccc actttggcag agagccagct gctgccatct caaggcccag ggcagatctc      900

cctgctgagg agccggcgcc cagcactcct ccatgtctgg tgcaggcaga agaggaggct      960

gtgtatgagg aacctccaga gcaggagacc ttctacgagc agcccccact ggtgcagcag     1020

caaggtgctg gctctgagca cattgaccac cacattcagg gccaggggct cagtgggcaa     1080

gggctctgtg cccgtgccct gtacgactac caggcagccg acgacacaga gatctccttt     1140

gaccccgaga acctcatcac gggcatcgag gtgatcgacg aaggctggtg gcgtggctat     1200

gggccggatg gccattttgg catgttccct gccaactacg tggagctcat tgagtgaggc     1260

tgagggcaca tcttgccctt cccctctcag acatggcttc cttattgctg gaagaggagg     1320

cctgggagtt gacattcagc actcttccag gaataggacc cccagtgagg atgaggcctc     1380

agggctccct ccggcttggc agactcagcc tgtcacccca aatgcagcaa tggcctggtg     1440

attcccacac atccttcctg catcccccga ccctcccaga cagcttggct cttgcccctg     1500

acaggatact gag                                                        1513


<210> 3565
<211> 1103
<212> DNA
<213> Homo sapiens

<400> 3565
cgcggctcca gggccacgtt ccagggtcgg gtttggtgga ttcctcagtc cctgccgccg       60

cggggcgccc tgggatagcg gcggggcctc ctgaacagat ctcggcccct ttccaaacac      120

tcctgatgcc tcatttgcct ctcgcttctt ttcgaccacc attttggggg ctgaggcact      180

cacggggcct ccccaggttt cactccgttt ctacacagtc ggagccccat ggatctccca      240

tctcccggag gaaccgtgaa gccaaacaga agcgcctgcg agagaagcag gctactctgg      300

aggctgagat agcaggggag agcaagtcac ctgcagaatc cattaaggcc tggaggccta      360

aggagttagt attgtatgaa atccctacga aacccggtga aaagaaagat gtctctgggc      420

ccctgcctcc tgcatacagc ccccgatatg ttgaggctgc ctggtacccg tggtgggtac      480

gagagggctt cttcaaacca gaatatcagg cccggctgcc ccaagctaca ggggagacct      540

tttccatgtg tatcccacct cccaatgtca ctggctccct gcacattggc cacgcactca      600

cggtggccat acaggatgcc ctcgtgcgct ggcaccggat gcgtggggat caagtgctgt      660

gggtccctgg ttcagatcat gcaggaattg ctacacaagc tgtggtggag aaacaactgt      720

ggaaggaacg gggagtgagg agacatgagc tgagccggga ggccttcctt agggaggtgt      780

ggcagtggaa ggaggcgaaa ggtggagaga tctgtgagca gctgcgagct ctgggtgcct      840

ccctggactg ggatcgagag tgttttacca tggatgttgg ctcctcagtg gctgtgactg      900

aagcttttgt gcggctctac aaggcggggt tgctgtaccg gaaccatcag cttgtcaact      960

ggtcatgtgc tttaagatca gccatctcgg acattgaggt ggagaaccgg cccctgcctg     1020

gccacacaca gcttcgactg cctggctgcc ccacccccgt gtcttttggc ctcctatttt     1080

ctgttgcctt ccccgtggat gga                                             1103


<210> 3566
<211> 887
<212> DNA
<213> Homo sapiens

<400> 3566
ccagggcaac cagaccgaga ggagcatgtg taacctgaaa caggtgagcc tatggagaca       60

gtacctaatg cgactgtgca cggaatatgt gtatgcagca tgagctccag ggaataaaac      120

tgcaaggtgt ggaatatttc tggcttctag tccaatgcca agtgtgtgac ctgtggctac      180

atgattccct gaaagataag aacaatgtta tgttggggat attggtctct gggccaacct      240

ggtatcagca ccaacctgca gggaattgtg gctgagcccc aggtgtgtgg gttcatatct      300

gacagaagtg tcaaggaagt ggcctgtggg ggaaaccact ctgtgttcct gctggaagat      360

ggggaagttt acacatgtgg tttgaacacc aaggggcaac tgggccatga gagggaagga      420

aacaagccag aacaaattgg agctctggca gatcagcata tcattcatgt ggcatgtggc      480

gagtcccaca gtctggccct cagtgaccga ggccagctgt tttcttgggg tgcagggagt      540

gatggtcagc taggactcat gactactgag gattctgtgg cagtgcccag gttaatacaa      600

aagctgaacc agcaaacaat attacaagtt tcctgtggca actggcattg cttggctctt      660

gcggctgatg gccagttctt cacctgggga aagaacagcc atgggcagct tggcttaggg      720

aaggagttcc cctcccaagc cagcccacag agggtgaggt ccctggaggg gatcccactg      780

gctcaggtgg ctgccggagg ggctcacagc tttgccctgt ctctctcagg agctgttttt      840

ggctggggga tgaataatgc cgggcagcta gggctcagtg atgaaaa                    887


<210> 3567
<211> 782
<212> DNA
<213> Homo sapiens

<400> 3567
tactttccca agcaccacca ggccaaaggt ctctcagttc agagcagaaa gccgtatacc       60

cagaggagca ggcagataac agaaacttcc agaaacctct gtggagacag tggaagaggc      120

aaaagggagt tcctgacagc tggattctag aagtagaact atgagctcac ctttggcctc      180

ccttagcaag acccgaaaag tgcccctgcc ctcggagcct atgaatcctg ggaggcgagg      240

aatccgcatc tatggagatg tccctgcatc ccatgactcg gagctgatgg ccttcatgac      300

gaggaagttg tgggacctgg agcagcaggt gaaggcccag actgatgaga tactgtccaa      360

ggatcagaag atagcggccc tagaggacct ggtgcagacc ctccggccac acccagccga      420

ggcaaccctg cagcggcagg aggaactgga gacgatgtgt gtgcagctgc agcggcaggt      480

cagggagatg gagcggttcc tcagtgacta tggcctgcag tgggtgggcg agcccatgga      540

ccaggaggac tcagagagca agacagtctc agagcatggc gagagggact ggatgacagc      600

caagaagttc tggaagccag gggactcatt ggcgccccct gaggtggact ttgacaggct      660

gctggccagc ctgcaggatc ttagtgagct ggtggtagag ggtgacaccc aagtgacacc      720

agtgcccggc ggggcacggc tgcgtaccct cgagcccatc ccgctgaagc tctaccggaa      780

tg                                                                     782


<210> 3568
<211> 938
<212> DNA
<213> Homo sapiens

<400> 3568
gcggcggcgg cagcggcagc ggcagcggcg ctgagttttg tctcccgggc cgtctgggcg       60

cgcgcgggtg tcccaggtac cccgccgcct ccctccttcc cgcaggactc gtccctcctg      120

gccctgggcc ccaacggtgc ccgcctgccc ggcggtcggt cagcgcacag ggcacggctt      180

cctctgcttc tcccggacca cttagtctca acccggaatg aaatatgact gaggactctc      240

agagaaactt tcgttcagta tattatgaga aagtggggtt tcgtggagtt gaagaaaaga      300

aatcattaga aattctccta aaagatgacc gtctgggaat cttgcctcca caccacgagt      360

cccatgccaa ggtgatgatg tatcgtaagg agcagtactt ggatgtcctt catgccctga      420

aagtcgttcg ctttgttagt gatgccacac ctcaggctga agtctatctc cgcatgtatc      480

agctggagtc tgggaagtta cctcgaagtc cctcttttcc actggagcca gatgatgaag      540

tgtttcttgc catagctaaa gccatggagg aaatggtgga agatagtgtc gactgttact      600

ggatcacccg acgctttgtg aaccaattaa ataccaagta ccgggattcc ttgccccagt      660

tgccaaaagc gtttgaacaa tacttgaatc tggaagatgg cagactgctg actcatctga      720

ggatgtgttc cgcggcgccc aaacttcctt atgatctctg gttcaagagg tgctttgcgg      780

gatgtttgcc tgaatccagt ttacagaggg tttgggataa agttgtgagt ggatcctgta      840

agatcctagt ttttgtagct gtcgaaattt tattaacctt taaaataaaa gttatggcac      900

tgaacagtgc agagaagata acaaagtttc tggaaaat                              938


<210> 3569
<211> 618
<212> DNA
<213> Homo sapiens

<400> 3569
gtacgggagc tggaggctga gcttgatgca gagcagaaga agcacgccga ggcccttaag       60

ggcgtgcgca agcatgagcg ccgtgtcaag gagctcgcat accaggccga ggaggacagg      120

aagaacctgg ctcgcatgca ggacctggtg gacaagctgc agagcaaggt caagagctac      180

aagcgccagt ttgaggaggc ggagcagcag gccaacacca acctggccaa gtatcgcaag      240

gcccagcacg agctggatga tgcggaggag cgggcagaca tggcggaaac ccaggccaac      300

aagctgcggg cacggacccg ggacgccctg ggccccaagc tatccctttc tcctcagcac      360

aaggagtgac ggcctgaccc cctgggctct aaagaggaat gtctgctgtt gcacatctgg      420

ctgaggccac ctgccccgat cctgccatct ctgcatcgcc ccctgctgcc ttcagccttc      480

cctgggccct gaataaacac cacagccagt ttccttctca ttcttttctt tggggttcag      540

gaggaaaaac acagtcctag ggacaaaagc caggtccaca gcagtcattt ttaaaataaa      600

gttatttaat agtctcca                                                    618


<210> 3570
<211> 591
<212> DNA
<213> Homo sapiens

<400> 3570
tgagtcccta gtaggcctcc aggagggcaa aagcaccgag cagggtaacc acgaccagct       60

taaagaactg tattcggctg ggaacttgac ggtgctggct actgaccccc tgctccacca      120

ggacccagta cagttagact ttcacttccg ccttacctcc cagacctctg cccattggca      180

cggccttctc tgtgaccgtc gactcttctt ggatatccca tatcaggcct tggatcaagg      240

caaccgggaa agtttgactg caaccctgga gtacgtggaa gagaagacaa atgtggactc      300

tgtgtttgtg aacttccaga atgatcggaa cgacagaggt gccctgctgc gggccttcag      360

ctacatgggc tttgaggtgg tcagaccaga tcaccctgcc ctccctccct tggacaatgt      420

catctttatg gtgtatcccc ttgaaaggga tgttggccac ctgcccagtg agcctccttg      480

aacatgctta ttccaacgct ttgaggggct ggaagccttg acacatggaa tcaggggccc      540

gggatgtgat tcaggacact ttccatccta ggaataaagg gtagtgcaat c               591


<210> 3571
<211> 505
<212> DNA
<213> Homo sapiens

<400> 3571
agaattcagc tgagagacag aggtcagaca tgccagcagg gttggaaaga ggcaggtacg       60

gaagctgagc tgcagagtta gccggcatct gacagaaaaa tgtgagtgtg ctgtggaagg      120

cttgcatttc ctttaaggta gacctctttg aaagtagaat tttcacggaa ttgttttctt      180

tctcactgag tgactgattt aacagaactc tcaccttcta tgcaagcgca cctagtttta      240

gagctccgtg acggcaatgt tcaattagtt cattattaac tgagcaatgc agaatgcttt      300

atccagggtg cttggagaag atgtcagagt ttgtctacag attttgagcg ttcgaagttg      360

acccctgact aagtatactt tgctgctccc tcagcctttg aaaaaatgtc tgtcacatat      420

gatgattccg ttggagtaga agtgtccagc gacagcttct gggaggtcgg gaactacaag      480

cggactgtga agcggatcga cgatg                                            505


<210> 3572
<211> 796
<212> DNA
<213> Homo sapiens

<400> 3572
ggcggtgggg gagtggctgg ggctgggggc ggtatcggac cgggtgggcg cggtagagtg       60

ggcttggtgg gttcccaggg ctggggttcg ttccgggtgg gctccgcttt gggaagaggc      120

ccagcggagg ggccttagtg tcagcgtagg gagagtgagg cggcgaaggc gggggcgggc      180

aaaggctagt ggagtcggga tgcgagggcg gtattcgtga cccggagctg tgcgaggaga      240

gtaccgagga gggggtcggc gggagaggag ataggactca agagtagcct tcctcgagga      300

cctgcctttc ccatttgctg cctgaagtta atgtttcttg ctggccaaat cagggacatg      360

ccggcattag cgggatgagt gggtgttccg gcagggatgt ggtcattgac ggccagtgag      420

ggcgagagta ccacggccca cttcttcctt ggagctggag atgaggggct gggcacccgt      480

ggaataggca tgaggccaga agagagtgac agcgagctcc ttgaggatga ggaggatgaa      540

gtgcctcctg aacctcagat cattgttggc atctgtgcca tgaccaagaa atccaagtcc      600

aagccaatga ctcaaatcct agagcgactc tgcagatttg actacctgac tgttgtcatt      660

ctgggagaag atgtaatcct taatgaacct gtggaaaact ggccatcctg ccactgcctc      720

atctctttcc actccaaagg ctttcctctg gacaaagctg ttgcttactc caagcttcga      780

aacccctttc ttatca                                                      796


<210> 3573
<211> 1519
<212> DNA
<213> Homo sapiens

<400> 3573
gatacagcag cagctggtgc tcctggccag gctgtgcgtg ctctctctgc ctctctctct       60

cggactctct gctctctctc tctgactctc tcctctctct ctgttggcct ggtgaaatgt      120

tcttggctgt aggcacacag agccttggac tcaaggctgt tggagtcgag gacaccttga      180

cttcggtcct ggaggttgaa attctgcctc tgagaagcta acagtcttcc tgtggtcgcc      240

actcctcccc agcagccccc tccttgccaa ggacggtcca gaaggagccc cactggggcc      300

tccccgctca gcaaagcaga cctcacctcc cactaccagc ttgaagtcac agcagccaga      360

ggaaattctg ccaccatttt cccaggtctg cagcccctcc agctgggaac ctgctcctgg      420

agccatccct ctgcaaacag agagcccaga gtgcctcggg gaaaattggc tgaataaaag      480

agcgatcagg acgccacggc tccgcctgaa gcgatggccc agccctaccc ccccgcccag      540

tacccccctc cgccacagaa cggcatccct gccgagtacg ccccgccccc accgcacccc      600

acgcaggact actccggcca gaccccggtc cccacagagc atggcatgac cctgtacaca      660

ccagcacaga cccaccccga gcagccaggc tccgaggcca gcacacagcc catcgccggg      720

acccagacag tgccgcagac agacgaggcg gcacagacgg acagccagcc gctccacccc      780

tccgacccta cagagaagca gcagcccaag cggctacacg tctccaacat ccccttccgg      840

ttcagggacc ccgacttgcg gcaaatgttc gggcaattcg gaaaaatttt agacgtggag      900

atcattttta acgagcgggg ctccaagggt tttgggtttg taacttttga aactagctca      960

gatgctgacc gagcccggga gaagctgaat gggacgatcg tagagggacg gaaaattgag     1020

gtcaataatg ccacggcccg agtgatgacc aacaagaaga cggggaaccc ctacaccaac     1080

ggctggaagc taaatccagt ggtcggcgca gtctacgggc ctgaattcta tgcagtgacg     1140

gggttcccct accccaccac cggcacagcc gttgcctacc ggggcgcaca tcttcggggc     1200

cggggccggg ccgtgtataa tacatttcgg gctgcgccac ccccaccccc catcccgact     1260

tacggagcgg tcgtgtatca ggatggattt tatggtgctg agatttatgg aggctacgca     1320

gcctacagat acgctcagcc cgctgcagcg gcggcagcct acagcgacag ttacggcaga     1380

gtctacgcag ctgccgaccc gtaccatcac accatcgggc ccgcggcgac ctacagcatt     1440

ggaaccatgt gaaaccttcc accgtttcct tctcggacca tgaagggcaa aaacaaaaaa     1500

acaaaaaaaa tcacaaaac                                                  1519


<210> 3574
<211> 2821
<212> DNA
<213> Homo sapiens

<400> 3574
tcagcatctt gaacagtaat gaacaccttc tgaaggaaaa agagcttctc attgacaagc       60

agaggaaaca catctctcag ctggagcaga aagtgcgaga gagcgaactg caagtccaca      120

gtgccctctt gggccgccct gccccctttg gtgatgtctg cttgctgagg ctacaggaat      180

tgcagcgaga aaacactttc ttacgtgcac agtttgcaca gaagacagaa gccttgagca      240

gagaaaagat tgaccttgaa aagaaactct ctgcttctga agttgaagtc cagctcatca      300

gagagtcgct caaagtggcg ttgcagaagc attctgagga agtgaagaaa caggaagaaa      360

gggtcaaagg tcgtgataaa catatcaata atttgaaaaa gaaatgccag aaggaatcag      420

agcagaaccg ggagaagcag cagcgtattg agaccttgga gcgctacctg gctgacctgc      480

ccacactgga agaccatcag aagcagagcc agcagcttaa ggattctgag ttgaagagca      540

cagagctgca ggagaaagtg actgagctgg agagtttgct ggaggagacc caggcaatct      600

gcagagagaa ggagattcaa ctggaaagcc tgaggcagag agaagcagaa ttctcctccg      660

ctggacatag cctgcaagat aaacagtctg tggaggagac cagtggagaa ggtccagaag      720

tggaaatgga gtcctggcag aagcgatacg attcgctcca aaagattgtg gagaagcagc      780

agcagaagat ggatcagttg cgctcacaag tacagagcct agagcaggaa gtggctcaag      840

aagaaggaac aagccaggcc ctgagagagg aggcccagcg aagggattca gccctgcagc      900

agctgcgcac agccgtgaag gagctttcag tgcaaaacca ggacttgatt gagaagaatc      960

tgacactcca ggaacacctg cgccaggccc aaccagggtc tccaccttca ccagacacgg     1020

cccagctggc acttgagctg caccaggagt tggccagttg ccttcaagat ctgcaggctg     1080

tctgtagcat tgtgacccag agggcccagg gccatgaccc caatctctcc ctgctcctgg     1140

gcattcactc acagcaccca gagactcagc tagatttgca gaagccagat gtgatcaaga     1200

ggaaactaga agaggttcaa cagctgcgtc gtgacattga ggacttaagg accaccatgt     1260

cagacagata tgcccaggac atgggagaaa actgtgtcac acagtgagga attctggggg     1320

attcccccag ggaggagctg ggctgctgag agcctagtcc agcaggtttc tgccctgaca     1380

ttctcttgtc tgctattccc agagaggtct cagaggggag gggagagcct gcatctgggg     1440

gccaagggct gattagggaa ctgtgtccta cccacactgg catgttggat tacgtttgtc     1500

ctgttaattc actctagacg gtgagttact aattaacttt tggcaggtac aacagataag     1560

tcctcacaaa ctgttcccag ccctaggctg acatgagaga cgaacaggct gtccaccttt     1620

cttctccatc caatgggatg gatccatgtt cattcccact tcacaccttg gtcctgctga     1680

ttagagagct catcagaggg gcctggaaag gctgagcaag taccagtgac aatggccatt     1740

taagaattct caggccccat gtgccagcct tcttgggaac tgagctggct ttctgggttt     1800

tctcatgcct ggtcttactg cttcttcctc agggctcttg ttctcccaga agcctcaggg     1860

taatgtgttg gttagcacgt aactactagg attggggccc tagggattat agccaggact     1920

ctaatctgcc taccatgcca tttaacaaga gatcccactc tccagctgcc ttgtgtccct     1980

agggtcctgg ccatgtgttt agtgtgctaa actttctcct ttgttctcag gccttccagg     2040

tagtcccctt cctggactta agagtgcaaa ctcttctctg tggttctagc cttgggcaga     2100

attatatccc agagaccaca gagcaactgt caagctgctt accccctcac ccagggctac     2160

agcctgtgcc cagccctcta atttgtgcct ctcttgtgtt gggggtggtg ggggttattc     2220

ctttcccttt cctgctctgg cctccttgaa agttcagagt acccagtaca agtcagcttt     2280

aaagtacagc ttttagtgtt tcctgggttg tttctctggg gctttagtga gggacctttg     2340

ccctctggtt tttcttgcct cctggtttag ggagcatctc acacttgtta gtatctggtt     2400

gttgggccag ccgtgcctcc tctagatctg gagccaggcc aggcaggggc cacgtgtggg     2460

ccagtcagcc actacaagat ttttgctaag ctttgggctg ttggcagcat cttggacctc     2520

atgcctgggc ctgaatgagg ctctttctta agtgttttta caagtttgtg ttttatttat     2580

ggagtgactt atcccttcca ttcagagcag ccccacccag ccagcccttc agcctctggg     2640

ctcctgctgc ttaaaggcag agccgcctgg ttggtctcca ccctgtgcat tgggagccca     2700

gccaccatgc tgacgggtat ttttcctcat aaagtttata accagttatt tatatgaatc     2760

tttgttatgt ccatttgttt gtattgcgta ttttgattat aaaataaagt atcttaacag     2820

a                                                                     2821


<210> 3575
<211> 673
<212> DNA
<213> Homo sapiens

<400> 3575
tttctgcgtt caatgtacat gtgttgagtc ccagtttctg ccgctttatc tttcccgcct       60

cccggcaggc aggccgttaa ccgtcttccg gaagacgctg ctagaaccct ccggccgctc      120

ctgcccgcca tcgtccccga acgacactcg ctcagctctc agggccagag cggggcagga      180

ggatgctttc ccagccccac catggagctg cgctgtgggg gattgctgtt cagttctcgc      240

tttgattcag ggaatctagc ccacgtggag aaggtggaat ctttgtccag tgatggggaa      300

ggggtaggag gtggggcgtc agccctgacc agtggcattg cctcttcccc tgactatgaa      360

ttcaacgtgt ggacccgacc agactgtgct gaaacggaat ttgagaatgg gaacaggtca      420

tggttctact tcagcgtccg gggaggaatg ccaggaaaac tcatcaagat caacattatg      480

aacatgaaca agcagagcaa gctgtattcc cagggcatgg ccccctttgt gcgcacactg      540

cccacccggc cacgctggga acgcattcga gaccggccca cctttgagat gacagagacg      600

cagtttgtgt tatcctttgt tcatcgtttc gtggagggcc gtggggccac caccttcttc      660

gccttctgct acc                                                         673


<210> 3576
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 3576
gggagattac ggggcgggga cgagctgtcg cgctggttgc tcgtgcagga gcgggacccg       60

gaacagaccg ccgtgagaga ggaggggtgc cggccgggat tcgcggcccg gagctcggga      120

ccggttgctt cattccagcc tcgcagtcac ctctgtgccc tgctggttgt cttcccagcg      180

ctgctgtagt tgccttccat ggatctatag gagagcaagt cctccaggag aagaagtcct      240

caccagtgaa cggagacctc tctgaactaa ggataccatg gccacgtcag ccccactacg      300

gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac      360

cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg      420

gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt      480

gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca      540

gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa      600

gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg      660

ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa      720

aatcctgaac cacctgagta ccctaaggag ggacagagac aaaattcagg gcttccaggc      780

aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat      840

tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga      900

acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg      960

cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca     1020

gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa     1080

gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga     1140

taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt     1200

ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct     1260

gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc     1320

ccagcagttt gactgtgagc ctggggtgct aggcagcaag ggcttcacct ggggcaaggt     1380

ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga     1440

ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga     1500

cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga     1560

ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag     1620

gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc     1680

cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag     1740

agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca     1800

ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct     1860

caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc     1920

caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc     1980

ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct ccccattgct     2040

gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt     2100

ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct     2160

ttcctttttg accacgacct tggccccagc tctgcactct ctggaataag ggcccgatgc     2220

agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc     2280

attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc     2340

ttccctggca ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa     2400

tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag     2460

cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc     2520

atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat     2580

ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga     2640

ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc     2700

aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc     2760

gggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact     2820

ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc     2880

ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa     2940

cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa     3000

ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa     3060

gttttaagtc ctccaccctg ttctaagaga ctgttccaac ggctctgggc ctcagtggtc     3120

acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca     3180

catgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta     3240

tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat     3300

aaagacttgt tgaatgaa                                                   3318


<210> 3577
<211> 6785
<212> DNA
<213> Homo sapiens

<400> 3577
ccgagccggg agccgagcgc gctgggcgcg gccgtcccgc tgccgccgcc aagcccggag       60

tgcgccagcg gccatggttc ccgcggcggc gccgggcgcc tgagccccgg gacgcaagcg      120

ctggaggcgg gctgccggct gtgcgggcgc tccggagaga ccgacagaag gtgagcactg      180

tgggctatgg gatggatgag gtggagcagg accagcatga ggcccgactc aaggagctgt      240

ttgacagttt tgacacgacg ggcacagggt ccctggggca ggaggaactc accgaccttt      300

gccacatgtt gagcttggag gaggtggccc cagtgctgca gcagacatta cttcaggaca      360

acctcttggg cagggtacat tttgaccaat ttaaagaagc attaatactc atcttgtcca      420

gaactctgtc aaatgaagaa cactttcaag aaccagactg ctcactagaa gctcagccca      480

aatatgttag aggtgggaag cgttacggac gaaggtcctt gcccgagttc caagagtccg      540

tggaggagtt tcctgaagtg acggtgattg agccactgga tgaagaagcg cggccttcac      600

acatcccagc cggtgactgc agtgagcact ggaagacgca acgcagtgag gagtatgaag      660

cggaaggcca gttaaggttt tggaacccag atgacttgaa tgcttcacag agtggatctt      720

cccctcccca agactggata gaagagaaac tgcaagaagt ttgtgaagat ttggggatca      780

cccgtgatgg tcacctgaac cggaagaagc tggtctccat ctgtgagcag tatggtttac      840

agaatgtgga tggagagatg ctcgaggaag tattccataa tcttgatcct gacggtacaa      900

tgagtgtaga agattttttc tatggtttgt ttaaaaatgg aaaatctctt acaccatcag      960

catctactcc atatagacaa ctaaaaaggc acctttccat gcagtctttc gatgagagtg     1020

gacgacgtac cacaacctca tcagcaatga caagtaccat tggctttcgg gtcttctcct     1080

gcctggatga tgggatgggc catgcatctg tggagagaat actggacacc tggcaggaag     1140

agggcattga gaacagccag gagatcctga aggccttgga tttcagcctc gatggaaaca     1200

tcaatttgac agaattaaca ctggcccttg aaaatgaact tttggttacc aagaacagca     1260

ttcaccaggc ggctctggcc agctttaagg ctgaaatccg gcatttgttg gaacgagttg     1320

atcaggtggt cagagaaaaa gagaagctac ggtcagatct ggacaaggcc gagaagctca     1380

agtctttaat ggcctcggag gtggatgatc accatgcggc catagagcgg cggaatgagt     1440

acaacctcag gaaactggat gaagagtaca aggagcgaat agcagcctta aaaaatgaac     1500

tccgaaaaga gagagagcag atcctgcagc aggcaggcaa gcagcgttta gaacttgaac     1560

aggaaattga aaaggcaaaa acagaagaga actatatccg ggaccgcctt gccctctctt     1620

taaaggaaaa cagtcgtctg gaaaatgagc ttctagaaaa tgcagagaag ttggcagaat     1680

atgagaatct gacaaacaaa cttcagagaa atttggaaaa tgtgttagca gaaaagtttg     1740

gtgacctcga tcctagcagt gctgagttct tcctgcaaga agagagactg acacagatga     1800

gaaatgaata tgagcggcag tgcagggtac tacaagacca agtagatgaa ctccagtctg     1860

agctggaaga atatcgtgca caaggcagag tgctcaggct tccgttgaag aactcaccgt     1920

cagaagaagt tgaggctaac agcggtggca ttgagcccga acacgggctc ggttctgaag     1980

aatgcaatcc attgaatatg agcattgagg cagagctggt cattgaacag atgaaagaac     2040

aacatcacag ggacatatgt tgcctcagac tggagctcga agataaagtg cgccattatg     2100

aaaagcagct ggacgaaacc gtggtcagct gcaagaaggc acaggagaac atgaagcaaa     2160

ggcatgagaa cgaaacgcac accttagaaa aacaaataag tgaccttaaa aatgaaattg     2220

ctgaacttca ggggcaagca gcagtgctca aggaggcaca tcatgaggcc acttgcaggc     2280

atgaggagga gaaaaaacaa ctgcaagtga agcttgagga ggaaaagact cacctgcagg     2340

agaagctgag gctgcaacat gagatggagc tcaaggctag actgacacag gctcaagcaa     2400

gctttgagcg ggagagggaa ggccttcaga gtagcgcctg gacagaagag aaggtgagag     2460

gcttgactca ggaactagag cagtttcacc aggagcagct gacaagcctg gtggagaaac     2520

acactcttga gaaagaggag ttaagaaaag agctcttgga aaagcaccaa agggagcttc     2580

aggagggaag ggaaaaaatg gaaacagagt gtaatagaag aacctctcaa atagaagccc     2640

agtttcagtc tgattgtcag aaagtcactg agaggtgtga aagcgctctg caaagcctgg     2700

aggggcgcta ccgccaagag ctgaaggacc tccaggaaca gcagcgtgag gagaaatccc     2760

agtgggaatt tgagaaggac gagctcaccc aggagtgtgc ggaagcccag gagctgctga     2820

aagagactct taagagagag aaaacaactt ctctggtcct gacccaggag agagagatgc     2880

tggagaaaac atacaaagaa catttgaaca gcatggtcgt cgagagacag cagctactcc     2940

aagacctgga agacctaaga aatgtatctg aaacccagca aagcctgctg tctgaccaga     3000

tacttgagct gaagagcagt cacaaaaggg aactgaggga gcgtgaggag gtcctgtgcc     3060

aggcaggggc ttcggagcag ctggccagcc agcggctgga aagactagaa atggaacatg     3120

accaggaaag gcaggaaatg atgtccaagc ttctagccat ggagaacatt cacaaagcga     3180

cctgtgagac agcagatcga gaaagagccg agatgagcac agaaatctcc agacttcaga     3240

gtaaaataaa ggaaatgcag caggcaacat ctcctctctc aatgcttcag agtggttgcc     3300

aggtgatagg agaggaggag gtggaaggag atggagccct gtccctgctt cagcaagggg     3360

agcagctgtt ggaagaaaat ggggacgtcc tcttaagcct gcagagagct catgaacagg     3420

cagtgaagga aaatgtgaaa atggctactg aaatttctag attgcaacag aggctacaaa     3480

agttagagcc agggttagta atgtcttctt gtttggatga gccagctact gagttttttg     3540

gaaatactgc ggaacaaaca gagcagtttt tacagcaaaa ccgaacgaag caagtagaag     3600

gtgtgaccag gcggcatgtc ctaagtgacc tggaagatga tgaggtccgg gacctgggaa     3660

gtacagggac gagctctgtt cagagacagg aagtcaaaat agaggagtct gaagcttcag     3720

tagagggttt ttctgagctt gaaaacagtg aagagaccag gactgaatcc tgggagctga     3780

agaatcagat tagtcagctt caggaacagc taatgatgtt atgtgcggac tgtgatcgag     3840

cttctgaaaa gaaacaggac ctactttttg atgtttctgt gctaaaaaag aaactgaaga     3900

tgcttgagag aatccctgag gcttctccca aatataagct gttgtatgaa gatgtgagcc     3960

gagaaaatga ctgccttcag gaagagctga gaatgatgga gacacgctac gatgaggcac     4020

tagaaaataa caaagaactc actgcagagg ttttcaggtt gcaggatgag ctgaagaaaa     4080

tggaggaagt cactgaaaca ttcctcagcc tggaaaagag ttacgatgag gtcaaaatag     4140

aaaatgaggg gctgaatgtt ctggttttga gacttcaagg caagattgag aagcttcagg     4200

aaagcgtggt ccagcggtgt gactgctgct tatgggaagc cagtttagag aacctggaaa     4260

tcgaacctga tggaaatata ctccagctca atcagacact ggaagagtgt gtgcccaggg     4320

ttaggagtgt acatcatgtc atagaggaat gtaagcaaga aaaccagtac cttgagggga     4380

acacacagct cttggaaaaa gtaaaagcac atgaaattgc ctggttacat ggaacaattc     4440

agacacatca agaaaggcca agagtacaga atcaagttat actggaggaa aacactactc     4500

tcctaggctt tcaagacaaa cattttcagc atcaggccac catagcagag ttagaactgg     4560

agaaaacaaa gttacaggag ctgactagga agttgaagga gagagtcact attttagtta     4620

agcaaaaaga tgtactttct cacggagaaa aggaggaaga gctgaaggca atgatgcatg     4680

acttgcagat cacgtgcagt gagatgcagc aaaaagttga acttctgaga tatgaatctg     4740

aaaagcttca acaggaaaat tctattttga gaaatgaaat tactacttta aatgaagaag     4800

atagcatttc taacctgaaa ttagggacat taaatggatc tcaggaagaa atgtggcaaa     4860

aaacggaaac tgtaaaacaa gaaaatgctg cagttcagaa gatggttgaa aatttaaaga     4920

aacagatttc agaattaaaa atcaaaaacc aacaattgga tttggaaaat acagaactta     4980

gccaaaagaa ctctcaaaac caggaaaaac tgcaagaact taatcaacgt ctaacagaaa     5040

tgctatgcca gaaggaaaaa gagccaggaa acagtgcatt ggaggaacgg gaacaagaga     5100

agtttaatct gaaagaagaa ctggaacgtt gtaaagtgca gtcctccact ttagtgtctt     5160

ctctggaggc ggagctctct gaagttaaaa tacagaccca tattgtgcaa caggaaaacc     5220

accttctcaa agatgaactg gagaaaatga aacagctgca cagatgtccc gatctctctg     5280

acttccagca aaaaatctct agtgttctaa gctacaacga aaaactgctg aaagaaaagg     5340

aagctctgag tgaggaatta aatagctgtg tcgataagtt ggcaaaatca agtcttttag     5400

agcatagaat tgcgacgatg aagcaggaac agaaatcctg ggaacatcag agtgcgagct     5460

taaagtcaca gctggtggct tctcaggaaa aggttcagaa tttagaagac accgtgcaga     5520

atgtaaacct gcaaatgtcc cggatgaaat ctgacctacg agtgactcag caggaaaagg     5580

aggctttaaa acaagaagtg atgtctttac ataagcaact tcagaatgct ggtggcaaga     5640

gctgggcccc agagatagct actcatccat cagggctcca taaccagcag aaaaggctgt     5700

cctgggacaa gttggatcat ctgatgaatg aggaacagca gctgctttgg caagagaatg     5760

agaggctcca gaccatggta cagaacacca aagccgaact cacgcactcc cgggagaagg     5820

tccgtcagtt ggaatccaat cttcttccca agcaccaaaa acatctaaac ccatcaggta     5880

ccatgaatcc cacagagcaa gaaaaattga gcttaaagag agagtgtgat cagtttcaga     5940

aagaacaatc tcctgctaac aggaaggtca gtcagatgaa ttcccttgaa caagaattag     6000

aaacaattca tttggaaaat gaaggcctga aaaagaaaca agtaaaactg gatgagcagc     6060

tcatggagat gcagcacctg aggtccactg cgacgcctag cccgtcccct catgcttggg     6120

atttgcagct gctccagcag caagcctgtc cgatggtgcc cagggagcag tttctgcagc     6180

ttcaacgcca gctgctgcag gcagaaagga taaaccagca cctgcaggag gaacttgaaa     6240

acaggacctc cgaaaccaac acaccacagg ccttgctacc ggagcagcga gcagtgcacg     6300

cagattccta cagaaggatt gggcacctgt gaaaactggg ctgctattga tggcatttct     6360

taccatggca gacagatgca cacacccacc catgcacaca caccacacac agagacataa     6420

gctaagatat gttggaatta agtgctcttt taaattattt tattattttt actgttaaac     6480

ctttgcagta ttatgtctct tatttattta tgtagaaatg acagatcttg tgaatcaaat     6540

tcacaaacat cagcttgtta caaatcattt tatttatacc ctttaaagag tgtggattta     6600

agattcttga aaggatgtag tctatatatt ttctcattcc atatgttgta actattttta     6660

accaaaggta ctacttttat atatggaatt tgaagaaaac caggggtatt tatactgttt     6720

tgtataagat gtacaaatct ttttgacagg aaatttttga tgaaacaata aaataaattt     6780

taagt                                                                 6785


<210> 3578
<211> 1218
<212> DNA
<213> Homo sapiens

<400> 3578
cgggcgccgc gggccatggc gggcgagaac caccagtggc agggcagcat cctctacaac       60

atgcttatga gcgcgaagca aacgcgcgcg gctcctgagg ctccagagac gcggctggtg      120

gatcagtgct ggggctgttc gtgcggcgat gagcccgggg tgggcagaga ggggctgctg      180

ggcgggcgga acgtggcgct cctgtaccgc tgctgctttt gcggtaaaga ccacccacgg      240

cagggcagca tcctctacag catgctgacg agcgcaaagc aaacgtacgc ggcaccgaag      300

gcgcccgagg cgacgctggg tccgtgctgg ggctgttcgt gcggctctga tcccggggtg      360

ggcagagcgg ggcttccggg tgggcggccc gtggcactcc tgtaccgctg ctgcttttgt      420

ggtgaagacc acccgcggca gggcagcatc ctctacagct tgctcactag ctcaaagcaa      480

acgcacgtgg ctccggcagc gcccgaggca cggccagggg gcgcgtggtg ggaccgctcc      540

tacttcgcgc agaggccagg gggtaaagag gcgctaccag gcgggcgggc cacggcgctt      600

ctgtaccgct gctgcttttg cggtgaagac cacccgcagc agggcagcac cctctactgc      660

gtgcccacga gcacaaatca agcgcaggcg gctccggagg agcggccgag ggccccctgg      720

tgggacacct cctctggtgc gctgcggccg gtggcgctca agagtccaca ggtggtctgc      780

gaggcagcct cagcgggcct gttgaagacg ctgcgcttcg tcaagtactt gccctgcttc      840

caggtgctgc ccctggacca gcagctggtg ctggtgcgca actgctgggc gtccctgctc      900

atgcttgagc tggcccagga ccgcttgcag ttcgagactg tggaagtctc ggagcccagc      960

atgctgcaga agatcctcac caccaggcgg cgggagaccg ggggcaacga gccactgccc     1020

gtgcccacgc tgcagcacca tttggcaccg ccggcggagg ccaggaaggt gccctccgcc     1080

tcccaggtcc aagccatcaa gtgctttctt tccaaatgct ggagtctgaa catcagtacc     1140

aaggagtacg cctacctcaa ggggaccgtg ctctttaacc cgggaaaagg gaaggaaaat     1200

gattgcaatc atcattaa                                                   1218


<210> 3579
<211> 1079
<212> DNA
<213> Homo sapiens

<400> 3579
cggaccggga gcagcggccg caggtccggg cgccatggct gcggagcgga cccggccgct       60

gcaaggctct ggcggtccga gcgtgcctag tagctgtgaa cccggcgcga ggtcccgggc      120

cccggggcgc tcgctcagaa aaatgaaact ctggatcacc tgattagtct gagtggggca      180

gtccagctca ggcatctctc caataaccta gagactctcc tcaagcggga cttcctcaaa      240

ctccttcccc tggagctcag tttttatttg ttaaaatggc tcgatcctca gactttactc      300

acatgctgcc tcgtctctaa acagtggaat aaggtgataa gtgcctgtac agaggtgtgg      360

cagactgcat gtaaaaattt gggctggcag atagatgatt ctgttcagga cgctttgcac      420

tggaagaagg tttatttgaa ggctattttg agaatgaagc aactggagga ccatgaagcc      480

tttgaaacct cgtcattaat tggacacagt gccagagtgt atgcacttta ctacaaagat      540

ggacttctct gtacagggtc agatgacttg tctgcaaagc tgtgggatgt gagcacaggg      600

cagtgcgttt atggcatcca gacccacact tgtgcagcgg tgaagtttga tgaacagaag      660

cttgtgacag gctcctttga caacactgtg gcttgctggg aatggagttc cggagccagg      720

acccagcact ttcgggggca cacgggggcg gtatttagcg tggactacaa tgatgaactg      780

gatatcttgg tgagcggctc tgcagacttc actgtgaaag tatgggcttt atctgctggg      840

acatgcctga acacactcac cgggcacacg gaatgggtca ccaaggtagt tttgcagaag      900

tgcaaagtca agtctctctt gcacagtcct ggagactaca tcctcttaag tgcagacaaa      960

tatgagatta agatttggcc aattgggaga gaaatcaact gtaagtgctt aaagacattg     1020

tctgtctctg aggatagaag tatctgcctg cagccaagac ttcattttga tggcaaata      1079


<210> 3580
<211> 884
<212> DNA
<213> Homo sapiens

<400> 3580
aaaatgctcc cgccgacgca cagcagtgac gacacacaag gtttcgggga ctgagtgggt       60

ttcagacttt ctctcaggat ttccgctggc ttcaggttcc ggtcaggcgt cgggacagag      120

cctgatccag gcttcggcgg ccggtggcag ctctcgatca gctctcgcag tcggagaggc      180

ggctaaggaa aggtgccaca gcagagacgc gaaggagagg ccctagaacc gaggtgttcc      240

tgctcatatg tttggcgtga caaagtttgg ggataacatt gaggatgaat ggtttattgt      300

ttatgtaata aagcagatca caaaggaatt tccagagtta gtagcaagga ttgaagacaa      360

tgatggtgaa ttcttgttaa tagaagctgc tgactttctc cctaaatggc tggatcctga      420

aaatagcacc aatagggtat ttttctgcca tggggaattg tgtattatcc ctgcaccaag      480

aaaatctgga gcagaatctt ggttacccac cacaccccca acaattccac aagcattgaa      540

tataatcaca gcacattcag aaaaaatact tgcttcagaa tctatacgag ctgctgtgaa      600

taggcgcatc agagggtacc cagaaaaaat tcaggcctca cttcatcgag cacactgctt      660

ccttccagct ggcattgtgg cagtgctaaa gcagcgcccc agattggtgg ctgcagcagt      720

ccaggcattt tacctacgag accctattga cctgcgagct tgtcgtgttt tcaagacatt      780

cttgcctgaa acacgaataa tgacatcggt cacattcact aaatgtctat atgcacaatt      840

ggtgcaacaa aggtttgtgc cagaccggcg gagtggatac aggc                       884


<210> 3581
<211> 603
<212> DNA
<213> Homo sapiens

<400> 3581
gtgcaggagc gggacccgga acagaccgcc gtgagagagg aggggtgccg gccgggattc       60

gcggcccgga gctcgggacc ggagaagaag tcctcaccag tgaacggaga cctctctgaa      120

ctaaggatac catggccacg tcagccccac tacggagcct ggaagaggag gtgacctgct      180

ccatctgtct tgattacctg cgggaccctg tgaccattga ctgtggccac gtcttctgcc      240

gcagctgcac cacagacgtc cgccccatct cagggagccg ccccgtctgc ccactctgca      300

agaagccttt taagaaggag aacatccgac ccgtgtggca actggccagc ctggtggaga      360

acattgagcg gctgaaggtg gacaagggca ggcagccggg agaggtgacc cgggagcagc      420

aggatgcaaa gttgtgcgag cgacaccgag agaagctgca ctactactgt gaggacgacg      480

ggaagctgct gtgcgtgatg tgccgggagt cccgggagca caggccccac acggccgtcc      540

tcatggagaa ggccgcccag ccccacaggg aaaaaatcct gaaccacctg agtaccctaa      600

gga                                                                    603


<210> 3582
<211> 6784
<212> DNA
<213> Homo sapiens

<400> 3582
gtgggctcgg cccgggctgc cacgagcgtg cgggcctcgc cgggcatgtc ctaggcggcg       60

gccccgccca gcgctcggcc gggcgggcgg gcgggcgcga gggcagggac cgagccgggc      120

cgagctgggg aacaagccgg ggaccaagcc ggggaccaag ccggggacta aggcgagccg      180

gagaccgagc ccgaacagca gggccagacg ggcccagcca gcaccaagat gagtgccacg      240

tcctggttcc tggtgagcag cagcggcgcc cgccaccggc tccctcggga gctcatcttc      300

gtggggcgtg aggagtgtga gctcatgcta cagtcccgca gcgtggacaa gcagcatgcc      360

gtcatcaact acgaccagga cagggacgag cactgggtga aggacctggg cagcctcaat      420

gggacgtttg tgaatgacat gcgcatcccg gaccagaagt acgtcacgct gaagctcaac      480

gatgtcatcc gcttcggcta cgattccaac atgtatgtgc tggagcgtgt gcagcaccga      540

gtcccggagg aggcactcaa gcatgaaaag tacaccagcc agctgcaggt gagcgtgaag      600

ggtttggcgc ccaagaggag cgaggcactg ccggaacaca caccatactg cgaggcctcg      660

aaccccaggc cggagaaggg ggaccggaga ccaggaacag aggcagcctc ttaccgcaca      720

cccctgtatg ggcagccctc ctggtggggt gaggacgatg gtagcacgct gcctgacgcc      780

cagcgccagg gagagcccta cccagcagag cgccccaagg gaccagtgca gcaggacggg      840

gagctccacg gcttccgcgc ccctgctgag cctcagggct gctcgttccg gcgggagccc      900

agctacttcg agatccccac gaaggagacc ccgcagccgt cgcagccccc cgaggtgccg      960

gcacacgaga tgcccacgaa ggatgcagag gcaggtgggg gcggagcggc ccctgtggtg     1020

cagagccacg cctccttcac catcgagttt gatgactgca gccctggcaa gatgaagatc     1080

aaggaccata tcaccaagtt ttccctgcgc cagcggcggc ccccgggcaa ggaggccaca     1140

cctggcgaga tggtgtcggc tgagaccaag gtggccgact ggctggtgca gaatgacccg     1200

agcctgctgc accgggttgg ccctggggat gaccgccaca gcaccaagag cgacctgcct     1260

gtccacaccc gcaccctgaa gggccacaag cacgaggacg gcacgcagag tgactcagag     1320

gaccccctgg ccaaggcggc ctcggccgct ggggtgccct tggaggccag cggggagcag     1380

gtgcggctgc agaggcagat caagcgggac ccccaggagc tactacataa ccagcaggcc     1440

tttgtcatcg agttcttcga cgaggacaca ccccgaaaga agcgctccca gtccttcacg     1500

cacagcccgt ccggggaccc caaggccgac aagcgccgtg gcccaacgcc ggccgatagg     1560

gaccgcccca gtgtcccagc cccagtccag gcagggggcc gcagctcggg gccacagagg     1620

gccggctcgc tcaagcggga gaagacagag gaacggctgg gcagcccctc gcccgcctcc     1680

cgaacccctg cccgcccctt cggaagcgtg gggcgccgct cccgcctggc ccaggacttc     1740

atggcccagt gtctgcggga gagctccccg gccgcccggc ccagccccga gaaggttcct     1800

ccggtgctgc ccgctcccct gacaccccat gggaccagcc ccgtgggccc cccgacccca     1860

ccgcccgccc ccacggaccc ccagctgacc aaggcacgga aacaggagga ggacgacagc     1920

ctcagtgacg cagggacata caccatcgag accgaggcgc aggacacgga ggtggaggag     1980

gcccggaaga tgatcgacca ggtctttggg gtgttggagt cccctgaact ctccagggca     2040

tcttcggcca cctttcgccc agtcatcaga ggggacagag atgagtctga tgacgggggc     2100

gtggcccagc ggatggcgct actgcaggag tttgcctccc ggccactggg tgcggccccc     2160

caggcggagc accagggcct cccggtgccg ggctcccctg ggggtcagaa gtgggtgtcc     2220

cgctgggcca gcctggctga cagctactca gacccgggcc tcacagagga tggcctggga     2280

cgtagaggcg gggagccgga ggggtccctg cctgtgcgca tgcggcgacg gctccctcag     2340

ctgcccagtg agagggctga cagccctgcg ggcccagaga gcagcaggag gagtgggcct     2400

gggccaccgg agctggacag tgagcagccc agccgcctct tcggccagga ggagttggat     2460

cctgacagcc tcagcgatgc cagtgggtcg gacgggggcc gaggccccga gccaggggtg     2520

gagccacagg acagcagacg caggagcccc caggaggggc ccacgtggag caggggtcgg     2580

cgctcaccaa gggcccccgg ggagccaact cccgcctctt tcttcattgg ggaccagaat     2640

ggggacgctg tgttatctag gaaaccgctt gcggctccag gggatgggga gggcctaggg     2700

cagacagccc agcccagccc cccagcacgg gatggcgtct atgtcagtgc caatgggaga     2760

atggtcatcc agctacggcc tggacggtcc ccagaacccg acggccctgc cccagccttt     2820

ctccggcaag agagcttcac taaggagcca gccagtggtc ccccagcgcc cggcaagccc     2880

ccccacatct ccagccaccc gcttctacag gacctggccg ctacccgggc cgcacgcatg     2940

gacttccact cccaggacac ccacctgatc ttgaaggaga cggagacggc cctggcggcc     3000

ctggaggccc gactcctctc taattctgtg gatgccgagt gtgagggggg cagcaccccg     3060

aggccgccgg aggacgccct gtctggggac tcggacgtgg acacagccag caccgtcagc     3120

ctgcgtagtg gcaagagcgg gcccagcccc acaacccccc agcctctgcg ggcacagaag     3180

gagatgtcgc catccccgcc agctgcacag gacccgggag gcaccgccct ggtcagtgcc     3240

cgtgagcagt cctcagagag gcagcatcac ccacttggcc cgacggacat gggccgtgga     3300

gagccggtac ggcgctcagc cataaggcgt ggccacaggc cccgagggtc cctggattgg     3360

cccagtgagg agcgtggccc tgtcctcgcc cacctaccca gctcagatgt gatggcctcc     3420

aaccacgaaa cccctgaggc caccggggca ggacggctag gttctcgccg gaaaccagcg     3480

gccccaccgc catccccagc tgcccgggag gagcagagcc gtagctcagc cagctcccag     3540

aaggggccgc aggccttgac ccgctccaac agcctgtcca cccctcgccc cacacgggcc     3600

tcccggctga ggcgggcccg gctgggggac gcttcagaca ctgaggctgc ggatggtgag     3660

cgggggtccc tgggcaaccc tgagcccgtg ggccggccag ctgctgagca ggccaagaag     3720

ctgtcacgcc tggacatcct ggccatgccc cggaagcggg ccggctcctt cacagggact     3780

agtgaccccg aggcagcccc tgcccgcacc agcttctctg gccgcagtgt ggagttgtgc     3840

tgtgccagcc gcaagcccac catggccgaa gcacgggctg tctccaggaa ggctgccaac     3900

acagccacca ccacgggtcc ccgccagccc ttcagcaggg cccgctcagg cagtgcccga     3960

tacacctcca acacgaggcg ccggcagcag ggctcggatt acacgtccac ctctgaggag     4020

gagtacggct cccgccacgg ctcccccaaa cacacacgct cccacacctc aacagccact     4080

cagaccccga gggctggcag ctccagccgg gctcgttccc gggcccccgg cccccgggac     4140

acggacgacg atgaggagga gcctgaccct tatggtttca tcgtgcagac ggcagagatt     4200

gcggagattg ccaggctgag ccagacgctg gtgaaggacg tggccatcct agcccaggag     4260

atccacgatg tggctgggga cggtgacaca ctgggctcct cggagcctgc ccacagcgcc     4320

tccctcagca acatgcccag cacccccgcc tcgaccatct ctgcccggga ggagctggtg     4380

cagcgcatcc ccgaggccag cctcaacttc cagaaggtgc cgcccggctc gctgaactct     4440

cgggactttg accagaacat gaacgacagc tgtgaggacg ccctggccaa caagacgcgg     4500

cctcggaacc gagaggaggt gatcttcgat aacctgatgc tgaacccggt gtcccagctg     4560

tcgcaggcca tccgtgagaa cacagagcac cttgccgaga agatgaagat cctctttcag     4620

aacacaggga gagcttggga ggacctggaa gccaggatca acgccgagaa cgaggtgccc     4680

atcctgaaga catctaacaa ggaaatcagc tccatcctga aggaactgag gcgggtgcag     4740

aaacagctgg aagttatcaa tgccatcgtg gaccccagtg ggagcctgga cctgctcaca     4800

ggaaacagga gcttggccag ctctgcacag ccggggctgg ggaagggccg cgtggctgcc     4860

cagagcccac cctcacccgc ctcagccgag gccctgctgc cagccctgcc cctgaggaat     4920

ttcccacagc gggccagctg tgggcctccc agcctcccgg accccacctt cctccctgat     4980

gccgagaggt tcctgatcta ggccccagac ctggccaggc cagcctccct gtgcgtgtgc     5040

gtctctgcct tccgtccgcc gcacacccgc ctgcctggcc gcaggtggtt ctccctgaag     5100

acccccacat gtgccatatc cctgtgggcg ggtgcctccc acgcccttgc cccctcgtca     5160

gctcccagcc agcaccctac tcaccctgtc cagccccatg gccaccccca cccctgcctc     5220

gccccctaca ggcctctggg cccagctcct ggccaggctg ctgccaaggt caagccctca     5280

agggcattac cccgcctcct cttcatcact gttatttttg tctttagctt taaaggaaag     5340

agttgttggt gccattgcag gtgccccctc caggcctgac tggctccgcc aggcactaac     5400

ctgccataac cctttgtgct ggcctgcggc caggcagagg aagagaggtc gactgtgggg     5460

tcatttggtg ccaaacatgg aggtgggcag gctcacctgt tcctgggact gtctgagatg     5520

gcagggcact tgccctggtg gctcccacct gaccccaggc cttttatagg caggagcccc     5580

actgcttcca gcctctggtg ccaacacagt tgccaaaccc attgagcttg gggctgccct     5640

gtggaggcct cctgggtatg gaccaggggc ttgttgagag ctgagccatg cacacaggtg     5700

cagacacccc ccaactccca tgcacacggc tagtccaggc gcctccacgc tgcaccgtga     5760

ggactgcagg gcatgtcccc gtgaggggct atgggcctct gtaggtgggc ttccaaggtc     5820

ctgggtgcag ccgggtgcat ggcagccctt ctggcggggg tgagcgcacg accaaagtca     5880

ctggaagccg ggtttccgga agctcgcagc ttggcctgca ccacacgccc tccccttttg     5940

gcttcacgcc atcaggcctc aagtgggcat gggggcaggg acgggcccag gaactgttgt     6000

tttctcagga ttctttcagc tgggaacatg gcaggtgagc agagcttggt gcctctgccg     6060

tggcccctgc tggggcagcc cgtgttgccg gagcctctaa gccaaagagc ccgttggccg     6120

tggttggtgg gggtggacgt gggggtgtcc cacctggacc agactggcgt gggtgagctc     6180

cacaccctgc ctggcaatgg tatgagagtc ggacctggac agggccagct gctgggggag     6240

cggcactggg gactggaggc tggaagcggg tggtgtgtgt cccctgttta cttttagctg     6300

agctggggtt gggtgtacgg gttctgttcc tctgagcctg cggcccacct gatgtttacg     6360

tgtgtgtgtg agggggggcg ggggtggcag gtgtcccccc ctggtccccg ccccaagagc     6420

ctgctgtctg tatggaggag gtgctagccc ggtccaccgg gctgctgccc acccctgcat     6480

gccccagttg cccaccccgc ctgcccctgg acatgaagtg gtcacgcttc atccacggct     6540

ccttcccacc cctcggcagt ggctgtgcaa tgttttaagt tcacaagttc ctgctcctcc     6600

ccacactgag ctcctttgtt cctccccctc cagcctttgc ctgggaactg gtccttgttt     6660

gccgggcttc tcggagggtt cactgtacat tcgttctcag gtggtcttgt ggctgtcttt     6720

cggaaaatgg ttattttata tgatttgtca tggaatttgt tctaataaat cattcttcta     6780

tcac                                                                  6784


<210> 3583
<211> 1897
<212> DNA
<213> Homo sapiens

<400> 3583
tcccggcgtg ccccgcggcg ggcgctgggc cggagccgga gcccaagcca gagcggcgcg       60

gcctggaaga ggccagggcc cgggggaggc ggcggcagcg gcggcggctg gggcagcccg      120

ggcagcccga gccccgcagc ctgggcctgt gctcggcgcc atgagcggcg gcgggccttc      180

gggaggcggc cctgggggct cgggcagggc gcggactagc tcgttcgcgg agcccggcgg      240

cggaggcgga ggaggcggcg gcggccccgg aggctcggcc tccggcccag gcggcaccgg      300

cggcggaaag gcatctgtcg gggccatggg tgggggcgtc ggggcctcga gctccggggg      360

tggacccggc ggcagcggcg gaggaggcag cggaggcccc ggcgcaggca ctagcttccc      420

gccgcccggg gtgaagctgg gccgtgacag cgggaaggtg accacagtcg tagccactct      480

aggccaaggc ccagagcgct cccaagaagt ggcttacacg gacatcaaag tgattggcaa      540

tggctcattt ggggtcgtgt accaggcacg gctggcagag accagggaac tagtcgccat      600

caagaaggtt ctccaggaca agaggttcaa gaaccgagag ctgcagatca tgcgtaagct      660

ggaccactgc aatattgtga ggctgagata ctttttctac tccagtggcg agaagaaaga      720

cgagctttac ctaaatctgg tgctggaata tgtgcccgag acagtgtacc gggtggcccg      780

ccacttcacc aaggccaagt tgaccatccc tatcctctat gtcaaggtgt acatgtacca      840

gctcttccgc agcttggcct acatccactc ccagggcgtg tgtcaccgcg acatcaagcc      900

ccagaacctg ctggtggacc ctgacactgc tgtcctcaag ctctgcgatt ttggcagtgc      960

aaagcagttg gtccgagggg agcccaatgt ctcctacatc tgttctcgct actaccgggc     1020

cccagagctc atctttggag ccactgatta cacctcatcc atcgatgttt ggtcagctgg     1080

ctgtgtactg gcagagctcc tcttgggcca gcccatcttc cctggggaca gtggggtgga     1140

ccagctggtg gagatcatca aggtgctggg aacaccaacc cgggaacaaa tccgagagat     1200

gaaccccaac tacacggagt tcaagttccc tcagattaaa gctcacccct ggacaaaggt     1260

gttcaaatct cgaacgccgc cagaggccat cgcgctctgc tctagcctgc tggagtacac     1320

cccatcctca aggctctccc cactagaggc ctgtgcgcac agcttctttg atgaactgcg     1380

atgtctggga acccagctgc ctaacaaccg cccacttccc cctctcttca acttcagtgc     1440

tggtgaactc tccatccaac cgtctctcaa cgccattctt atccctcctc acttgaggtc     1500

cccagcgggc actaccaccc tcaccccgtc ctcacaagct ttaactgaga ctccgaccag     1560

ctcagactgg cagtcgaccg atgccacacc taccctcact aactcctcct gagggcccca     1620

ccaagcaccc ttccacttcc atctgggagc cccaagaggg gctgggaagg ggggccatag     1680

cccatcaagc tcctgccctg gctgggcccc tagactagag ggcagagaaa acgtcgattc     1740

gcaccgtcca acctggcccc gcccctccta cagctgtaac tcccctcctg tcctctgccc     1800

ccaaggtcta ctccctcctc accccaccct ggagggccag gggagtggag agagctcctg     1860

atgtcttagt ttccacagta aggtttgcct gtgtaca                              1897


<210> 3584
<211> 2589
<212> DNA
<213> Homo sapiens

<400> 3584
ctgagctgag tgacaggaag acggttcaat gggcggcgcg gaggcggagc cgtgggggcg       60

ggctcccggt cccgctatcg gcggccggcg ggcaggcgac tcctgtcccg ggtggaggcg      120

gcggagccgg agccggggga gggggcagcg gctgtctcac ggaccacggc ggcgcccgca      180

gctcctcacc gcagcacccc cactgcaggc ccgaggagct ttccggagct tcccacactc      240

ctggggagaa gacttcttag ccagcttgat gtttaaaatt cagctggagc ccttaaaact      300

tcgagcgtgg acgctgaatg ggtttgtaaa gtttcgaaac aaggagacca gtgctggtcc      360

agtggctgtg atgggaaaag attattacaa gattcttggg atcccatcgg gggccaacga      420

ggatgagatc aagaaagcct accggaagat ggccttgaag taccacccag acaagaataa      480

agaacccaac gctgaggaga agtttaagga gattgcagag gcctatgatg tgctaagtga      540

ccccaagaaa cggggcctgt atgaccagta tggggaggaa ggcctgaaga ccggcggtgg      600

cacatcaggt ggctccagtg gctcctttca ctacaccttt catggggacc cccatgccac      660

ctttgcctcc ttctttggtg gctccaaccc cttcgatatc ttctttgcca gcagccgctc      720

cactcggccc ttcagtggct ttgacccaga tgacatggat gtggatgaag atgaggaccc      780

atttggcgct ttcggccgtt ttggcttcaa tgggctgagt aggggtccaa ggcgagcccc      840

agaaccactg taccctcggc gcaaggtgca ggacccccca gtggtgcacg agctgcgggt      900

gtccctggag gagatctacc atggctccac caagcgcatg aagatcacaa ggcgtcgcct      960

caaccctgat gggcgaactg tgcgcaccga ggacaagatc ctgcacatag tcatcaagcg     1020

tggctggaag gaaggcacca agatcacctt ccccaaagaa ggcgacgcca cacctgacaa     1080

catccctgct gacatcgtct ttgtgctcaa agacaagccc catgcacact tccgccgaga     1140

tggcaccaac gtgctctaca gtgccctgat cagcctcaag gaggcgctgt gtggctgcac     1200

tgtgaacatt cccactatcg acggccgagt gatccctttg ccctgcaatg atgtcatcaa     1260

gccaggcacc gtgaagagac tccgtgggga gggccttccc ttccccaaag tgccaactca     1320

gcgaggagac ctcattgttg agttcaaagt tcgcttccca gacagattaa caccacagac     1380

aagacagatc cttaagcagc acctaccctg ttcctaggct ctgccccagc cagtccagag     1440

cctaccacag caataccccc aacactcact ccactcaatg tgcacccagc ttgatgtcca     1500

ctggacactg gcaacttttt ctaaaatgca aaaaaaagcc actggttttc aggaaaatgt     1560

tcctgtccct gacccctttt agagctgggc tgcctggggg gagtgggagg gaggtgggga     1620

gagctagccc aggccagggg tcaatgttca tgtcactagc tttcaatcca gtttccactg     1680

cagtggctgg agagtgacct gagtgctact tgaagatatg tagagattcc ttatccatgc     1740

ctgtacatag catgtcctcc tcccctcagc tttgctaata ccagtcccct cccttccctt     1800

tggcttcctg ctgttggggg tggaaaagac tagaaaggac attgctttct cagccccacc     1860

cccaggtcca cagtgtccaa ggtaatggca cacatattca tgcacaagaa gcactcacct     1920

agagctgtct gtgcctctct gggagaaagg agagaggata agaagggaaa gttcacaacc     1980

tgtgaacagg gacttgagca cgagacactt ttcatctgga gcaggggggt gagctcctca     2040

gcagcctccg taacagctgc cctgcctaca cctgcagagc tggaggttct gtcctccctg     2100

ctgctctcag gagtgttcaa gggtggaggg cagggaatgg ggcctgaggt attaaggcta     2160

agaggtgggg gacagggccc atctaccagc cttcatcagg aagggaaagg gctttggggt     2220

caggtggcag ctattcccca ccaagagatt cagggtcaca ggtttttccc cacacctctg     2280

aactcagggc ctagccaccc ccaaacttcc aaatcccact tttgtgatat gtgaagctac     2340

tcatttctta cccttggagg ctgtgtgggg aatttccagc ccttttatgc ctgtgtgatc     2400

ccaccccacc cccatagttg tataaaggtc atagtgaaga agctggggga agactgcttc     2460

agccagatcc tggggtgggg tctttaggtt ttctcacttt gacaaccccc gaatgttttt     2520

atagtagttt ttttgtattt ttttgtaatg acagtattat gtaaaaaata aagtatttta     2580

aaaatatgg                                                             2589


<210> 3585
<211> 503
<212> DNA
<213> Homo sapiens

<400> 3585
gtctatggag ccaaagatat tgaactctct cctgaggcac aagccaaaat agatcgttac       60

actcaacagg gttttggaaa tttgcccatc tgcatggcaa agacccacct ttctctatct      120

caccaacctg acaaaaaagg tgtgccaagg gacttcatct tacctatcag tgacgtccgg      180

gccagcatag gcgctgggtt catttaccct ttggtcggaa cgagaagctc ccctctggct      240

ctagttggag aatcccaacc caagcaagtc catccttaaa caataaacat ctccagcatt      300

gctggctttg gaagacccca tggtgagatg ctggagcttt tttccgctcc agatttcgct      360

tctaaatatt tacttttact ttccatgttc acttataggc cagggttttt ttttcctacc      420

attgaattat ttcgtcatgt tctatttaat tattgcttta attggcattg gtgaccacaa      480

ataataataa atactattaa ctg                                              503


<210> 3586
<211> 818
<212> DNA
<213> Homo sapiens

<400> 3586
gggtctgggc agggctgggc agtgctgccg gagcaaaagc ggtagcggga gcccggccgg       60

agctgggtct ggagacgccg tggcagcctg aacggagtgt gcgacggatt gggaggagga      120

actgccaggt cggatgtgga gatgaacccg gagagtgtcc ttcggctctg gtcggccttc      180

aggggcattc ctgccagtct cagaagatga cagtctgcaa tcgtgttatc atcaacgtgg      240

aaaaaataag ggcaatgcag ttttcatgtg tgtaaggttt gtctacagat tttgagcgtt      300

cgaagttgac ccctgactaa gtatactttg ctgctccctc agcctttgaa aaaatgtctg      360

tcacatatga tgattccgtt ggagtagaag tgtccagcga cagcttctgg gaggtcggga      420

actacaagcg gactgtgaag cggatcgacg atggccaccg cctgtgcagc gacctcatga      480

actgcctgca tgagcgggcg cgcatcgaga aggcgtatgc gcagcagctc actgagtggg      540

cccggcgctg gaggcagctc gtggagaaag ggccccagta cgggaccgtg gagaaggcct      600

ggatggcctt catgtccgag gcagagaggg tgagcgagct gcacctcgag gtgaaggcct      660

cactgatgaa cgatgacttc gagaagatca agaactggca gaaggaagcc tttcacaagc      720

agatgatggg cggcttcaag gagaccaagg aagctgagga cggctttcgg aaggcacaga      780

agccctgggc caagaagctg aaagaggtac atctgtcc                              818


<210> 3587
<211> 1476
<212> DNA
<213> Homo sapiens

<400> 3587
gaaagagcag aagaggaggt ggggtggagg gagcagagcc agggattagg ggactactga       60

ggctctggag atgagaccgc caggagtcct tccccaccat gagccccctc cactcctgca      120

gctggaggag tttttcccag tctcagtgct gccctggggc gagagagact gaacaagctg      180

tttgggtggg aagagaatgg aggaagttga cagggatggg cggggcccgt gggggggctg      240

accaggaacc cagcttcctg ctcagtaccc aggcatccag cccccagctc acccccaccc      300

cttccagccc ccactcccct caggaaccca aggttccagc cctcctccca aatcccagcc      360

acccctcccc caccagtttc tcccctctag gggatggagg ctgagagacc ccaggaagaa      420

gaggatggtg agcagggccc ccctcaggat gaggaaggct ggccccctcc aaactccacc      480

actcggcctt ggcgatctgc tcctccgtcc cctcctcctc cagggacccg ccacacagcc      540

ctgggacccc gctcggcctc cctgctctcc ctgcagactg aactccttct ggacctggtg      600

gctgaagccc agtcccgccg cctggaggag cagagggcca ccttctacac cccccaaaac      660

ccctcaagcc tagcccctgc cccactccgt cctctcgagg acagagaaca gctttacagc      720

actatcctca gtcaccagtg ccagcggatg gaagcccagc ggtcagagcc tcccctccct      780

ccaggggggc aagagctcct ggagttgctg ctgagagttc agggtggggg tcgaatggag      840

gagcaaaggt cccggccccc cacacacacc tgctgagact tgagccccaa ccagcccttc      900

cttgccactg gtctcaaagc tgggcagccc attgcatgcc ctcaactctt gcttggcagg      960

ggtaccagag actgaaagac acggcacaaa tctcaatatt catctcccac atcaccttcc     1020

ctgggaactg gacagggtga aagtcctcaa actctgggaa caggcgagat ggaacaggga     1080

tttaactccc cgcccacagg tccatgggag cttgaggcag taagggggat cccaggcacc     1140

catctcaagg agtggctggg agtcttttcc ctaacttgtg gggacaccac cagttgtcaa     1200

gctactaggc agtagggtct gagggctcag gcctccacct gagaggttat aacctgagag     1260

acagctctac ccttcctccc agtaagaagg gaaggtgggt gggcacctga gagattaaga     1320

ctattctccc agtcccacta ccagcacccc cgatccctga gactgagggg tttacgggct     1380

gtgaatggac cttcagccct gcccaccctc cctccccact gctgctgagt ctgtctgatg     1440

ttttggttgt gtgaataaat ataattcccc tctgga                               1476


<210> 3588
<211> 998
<212> DNA
<213> Homo sapiens

<400> 3588
gcaccgctga gctgccgaga ggaagctcgc tctgcccggc tgccctcttg tagtccgccg       60

gcgaggggca gttctcggtg aggaggaaga gagcagcgga cggcacagca cccgcgcggg      120

ccctccggca ggcggcttct cagagttttc aggtggcgaa actgactggt ctggttagag      180

cgcgtccaag ccaagccgca gtgctgtttg gatttttaaa tttctccttc tgagtgagaa      240

aatagcaatc gagatggaac catccgcaca acagctccag ctggcagcat cacttcccgc      300

caatttatcc aacttctgcc aaggctctga aatgccaaca acgtcgaggc ctgcacttga      360

tgtcaagggt ggcacctcac ctgcgaagga ggatgccaac caagagatga gctccgtggc      420

ctactccaac cttgcggtga aagatcgcaa agcagtggcc attctgcact accctggggt      480

agcctcaaat ggaaccaagg ccagtggggc tcccactagt tcctcgggat ctccaatagg      540

ctctcctaca accacccctc ccactaaacc cccatccttc aacctgcacc ccgcccctca      600

cttgctggct agtatgcacc tgcagaaact taatagccag tatcagggga tggctgctgc      660

cactccaggc caacccgggg aggcaggacc cctgcaaaac tgggactttg gggcccaggc      720

gggaggggca gaatcactct ctccttctgc tggtgcccag agccctgcta tcatcgattc      780

ggacccagtg gatgaggaag tgctgatgtc gctggtggtg gaactggggt tggaccgagc      840

caatgagctt ccggagctgt ggctggggca gaatgagttt gacttcactg cggactttcc      900

atctagctgc taatgccaag tgtccctaaa gatggaggaa taaagccacc aattctgttg      960

taaataaaaa taaagttact tacaaagaga cgggccaa                              998


<210> 3589
<211> 558
<212> DNA
<213> Homo sapiens

<400> 3589
aaaaccgcat ccccgcagga ggctcggccg ccgcgcgccc gcggccctcc gtcccgcccc       60

ggccggctgg cggtcacctg gcacaccagc gcccgcagga tgcccagaaa cagagcctca      120

ctctgtcacc taggctggag tgcagtggtg caattatggc tcactgcagt ttcaacctcc      180

cagattccag tcatcctcct gcctcagcca cccaagaagc tgggaccaca ggtactgctt      240

aggatgaata tgatttggag aaattccatt tcttgtctaa ggctaggaaa ggtgccacac      300

agataccaaa gtggttacca cccagtggcc cctctgggat caaggatttt aactgaccca      360

gccaaagttt ttgaacacaa catgtgggat cacatgcagt ggtctaagga agaagaagca      420

gcagccagaa aaaaagtaaa agaaaactca gctgtgcgag tccttctgga agagcaagtt      480

aagtatgaga gagaagctag taaatactgg gacacatttt acaagattca taagaataag      540

tttttcaagg atcgtaat                                                    558


<210> 3590
<211> 361
<212> DNA
<213> Homo sapiens

<400> 3590
ggaaggagag tctccaacgg catcacccca ctcatctgcc accgatgacc tccaccattc       60

agacagatac cagacctttc tgcgagtacg agccaaccgg cagacccgac tgaatgctcg      120

gattgggaaa atgaaacgga ggaagcaaga tgaagggcag gtatgtcccc tgtgcaaccg      180

ccccctggca ggatcggagc aggagatgag taggcatgtg gagcattgcc tttctaagag      240

ggaaggctcc tgcatggctg aggatgatgc tgtggacatc gagcatgaga acaacaaccg      300

ctttgaggag tatgagtggt gtggacagaa gcggatacgg gccaccactc tcctggaagg      360

t                                                                      361


<210> 3591
<211> 3010
<212> DNA
<213> Homo sapiens

<400> 3591
actgctcctt ctctcacgcc aactgagtct cttgatctgt acatgcaatc ccaggcagct       60

cgcgaacaca aacccggggc cagccgccta ctgctgctgc tgctgctgcc gctgccgccg      120

ccgccgccgc cgctgcctcc gccggctctg cgaacccggg acttttcatg caccacactc      180

tccgcctgct tccctccgtg tcctgaaaag tgcgaccgtt ctcccaagga atttccacgg      240

caagtcttag gagggaatga ttccccagta atattccctg ccctgaccca aagtgctggt      300

tggcctccct cccagggaag actgcttctt gcgtaacgcc ggccacagaa agagactccg      360

atggacttac accgggcagc cttcaagatg gagaactcat cctaccttcc caaccctctg      420

gcatccccag cactgatggt cctggcatcc acggctgagg ccagccgtga tgcttccatc      480

ccttgtcagc agccacgacc ctttggtgta cctgtctcag ttgacaagga cgtgcatatt      540

cctttcacca acggttccta tacctttgcc tctatgtacc atcggcaagg tggggtgcca      600

ggcacttttg ccaatcgtga tttcccccct tctctactac acctccaccc tcaatttgct      660

cccccaaatc tagattgcac cccaatcagt atgctgaatc atagtggtgt gggggctttc      720

cggccctttg cctccaccga ggaccgggag agctatcagt cagcctttac gccggccaag      780

cgacttaaga actgccatga cacagagtct ccccacttgc gcttctcaga tgcagatggc      840

aaggaatatg actttgggac acagctgcca tctagctccc ccggttcact aaaggttgat      900

gacactggga agaagatttt tgctgtctct ggcctcattt ctgatcggga agcctcatct      960

agcccagagg atcggaatga cagatgtaag aagaaagcag cggcattgtt cgacagccag     1020

gccccaattt gccccatctg ccaggtcctg ctgaggccca gtgagctgca ggagcatatg     1080

gagcaggaac tggagcagct agcccaactg ccctcgagca agaattccct tctgaaggat     1140

gccatggctc caggcacccc aaagtccctc ctgttgtctg cttccatcaa gagggaagga     1200

gagtctccaa cggcatcacc ccactcatct gccaccgatg acctccacca ttcagacaga     1260

taccagacct ttctgcgagt acgagccaac cggcagaccc gactgaatgc tcggattggg     1320

aaaatgaaac ggaggaagca agatgaaggg cagagggaag gctcctgcat ggctgaggat     1380

gatgctgtgg acatcgagca tgagaacaac aaccgctttg aggagtatga gtggtgtgga     1440

cagaagcgga tacgggccac cactctcctg gaaggtggct tccgaggctc tggcttcatc     1500

atgtgcagcg gcaaagagaa cccggacagt gatgctgact tggatgtgga tggggatgac     1560

actctggagt atgggaagcc acaatacaca gaggctgatg tcatcccctg cacaggcgag     1620

gagcctggtg aagccaagga gagagaggca cttcggggcg cagtcctaaa tggcggccct     1680

cccagcacgc gcatcacacc tgagttctct aaatgggcca gtgatgagat gccatccacc     1740

agcaatggtg aaagcagcaa gcaggaggcc atgcagaaga cctgcaagaa cagcgacatc     1800

gagaaaatca ccgaagattc agctgtgacc acgtttgagg ctctgaaggc tcgggtcaga     1860

gaacttgaac ggcagctatc tcgtggggac cgttacaaat gcctcatctg catggactcg     1920

tactcgatgc ccctaacgtc catccagtgt tggcacgtgc actgcgagga gtgctggctg     1980

cggaccctgg gtgccaagaa gctctgccct cagtgcaaca cgatcacagc gcccggagac     2040

ctgcggagga tctacttgtg agctatctgc cccaggcagg cctcgcctcc agcagcccca     2100

cctgccccca gcctctgtga cagtgaccgt ctccctttgt acatacttgc acacaggttc     2160

cccatgtaca tacatgcaca tactcaaaca tgcgtacaca cacacacatt tacacacgca     2220

ggactctgga gccagagtag aggctgtggc ccaggcacta cctgctggct cccacctatg     2280

gtttgggggc catacctgtt ccagctctgt tcccagggtg gggcagggag gtgggggttg     2340

ggggagtagt ggggcacggc tcctaagatc cagcccccat actgacagac ggacagacag     2400

acatgcaaac accagactga agcacatgta atatagaccg tgtatgttta caatgttgtg     2460

tataaatggg acaactcctc gccctctacc tgtcccctcc ccctttggtt gtatgatttt     2520

cttctttttt aagaacccct ggaagcagcg cctccttcag ggttggctgg gagctcggcc     2580

catccacctc ttggggtacc tgcctctctc tctcctgtgg tgtcccttcc ctctcccatg     2640

tgctcggtgt tcagtggtgt atatttcttc tcccagacat ggggcacacg ccccaaggga     2700

catgatcctc tccttagtct tagctcatgg ggctctttat aaggagttgg ggggtagagg     2760

caggaaatgg gaaccgagct gaagcagagg ctgagttagg gggctagagg acagtgctcc     2820

tggccaccca gcctctgctg agaaccattc ctgggattag agctgccttt cccagggaaa     2880

aagtgtcgtc tccccgaccc tcccgtgggc cctgtggtgt gatgctgtgt ctgtatattc     2940

tatacaaagg tacttgtcct ttccctttgt aaactacatt tgacatggat taaaccagta     3000

taaacagttg                                                            3010


<210> 3592
<211> 5169
<212> DNA
<213> Homo sapiens

<400> 3592
gcgcatcagg cgctgttgtt ggagccggaa caccgtgcga ctctgaccga accggccccc       60

tcctcgcgca cacactcgcc gagccgcgcg cgcccctccg ccgtgacagt ggccgtggcc      120

tccgctctct cggggcaccc ggcagccaga gcgcagcgag agcgggcggt cgccagggtc      180

ccctccccag ccagtcccag gcgcccggtg cactatgcgg ggcacgtgcg ccccccagct      240

ctaatctgcg cgctgacagg agcatgatct gtgcccaggc cagggctgcc aaggaattga      300

tgcgcgtaca cgtggtgggt cattatgctg ctgcacctgt gtagtgtgaa gaatctgtac      360

cagaacaggt ttttaggcct ggccgccatg gcgtctcctt ctagaaactc ccagagccga      420

cgccggtgca aggagccgct ccgatacagc tacaaccccg accagttcca caacatggac      480

ctcaggggcg gcccccacga tggcgtcacc attccccgct ccaccagcga cactgacctg      540

gtcacctcgg acagccgctc cacgctcatg gtcagcagct cctactattc catcgggcac      600

tctcaggacc tggtcatcca ctgggacata aaggaggaag tggacgctgg ggactggatt      660

ggcatgtacc tcattgatga ggtcttgtcc gaaaactttc tggactataa aaaccgtgga      720

gtcaatggtt ctcatcgggg ccagatcatc tggaagatcg atgccagctc gtactttgtg      780

gaacctgaaa ctaagatctg cttcaaatac taccatggag tgagtggggc cctgcgagca      840

accaccccca gtgtcacggt caaaaactcg gcagctccta tttttaaaag cattggtgct      900

gatgagaccg tccaaggaca aggaagtcgg aggctgatca gcttctctct ctcagatttc      960

caagccatgg ggttgaagaa agggatgttt ttcaacccag acccttatct gaagatttcc     1020

attcagcctg ggaaacacag catcttcccc gccctccctc accatggaca ggagaggaga     1080

tccaagatca taggcaacac cgtgaacccc atctggcagg ccgagcaatt cagttttgtg     1140

tccttgccca ctgacgtgct ggaaattgag gtgaaggaca agtttgccaa gagccgcccc     1200

atcatcaagc gcttcttggg aaagctgtcg atgcccgttc aaagactcct ggagagacac     1260

gccatagggg atagggtggt cagctacaca cttggccgca ggcttccaac agatcatgtg     1320

agtggacagc tgcaattccg atttgagatc acttcctcca tccacccaga tgatgaggag     1380

atttccctga gtaccgagcc tgagtcagcc caaattcagg acagccccat gaacaacctg     1440

atggaaagcg gcagtgggga acctcggtct gaggcaccag agtcctctga gagctggaag     1500

ccagagcagc tgggtgaggg cagtgtcccc gatggtccag ggaaccaaag catagagctt     1560

tccagaccag ctgaggaagc agcagtcatc acggaggcag gagaccaggg catggtctct     1620

gtgggacctg aaggggctgg ggagctcctg gcccaggtgc aaaaggacat ccagcctgcc     1680

cccagtgcag aagagctggc cgagcagctg gacctgggtg aggaggcatc agcactgctg     1740

ctggaagacg gtgaagcccc agccagcacc aaggaggagc ccttggagga ggaagcaacg     1800

acccagagcc gggctggaag ggaagaagag gagaaggagc aggaggagga gggagatgtg     1860

tctaccctgg agcagggaga gggcaggctg cagctgcggg cctcggtgaa gagaaaaagc     1920

aggccctgct ccttgcctgt gtccgagctg gagacggtga tcgcgtcagc ctgcggggac     1980

cccgagaccc cgcggacaca ctacatccgc atccacaccc tgctgcacag catgccctcc     2040

gcccagggcg gcagcgcggc agaggaggag gacggcgcgg aggaggagtc caccctcaag     2100

gactcctcgg agaaggatgg gctcagcgag gtggacacgg tggccgctga cccgtctgcc     2160

ctggaagagg acagagaaga gcccgagggg gctactccag gcacggcgca ccctggccac     2220

tccgggggcc acttccccag cctggccaat ggcgcggccc aggatggcga cacgcacccc     2280

agcaccggga gcgagagcga ctccagcccc aggcaaggcg gggaccacag ttgcgagggc     2340

tgtgacgcgt cctgctgcag cccctcgtgc tacagctcct cgtgctacag cacgtcctgc     2400

tacagcagct cgtgctacag cgcctcgtgc tacagcccct cctgctacaa cggcaacagg     2460

ttcgccagcc acacgcgctt ctcctccgtg gacagcgcca agatctccga gagcacggtc     2520

ttctcctcgc aagacgacga ggaggaggag aacagcgcgt tcgagtcggt acccgactcc     2580

atgcagagcc ctgagctgga cccggagtcc acgaacggcg ctgggccgtg gcaagacgag     2640

ctggccgccc ctagcgggca cgtggaaaga agcccggaag gtctggaatc ccccgtggca     2700

ggtccaagca atcggagaga agactgggaa gctcgaattg acagccacgg gcgggtcttt     2760

tatgtggacc acgtgaaccg cacaaccacc tggcagcgtc cgacggcagc agccaccccg     2820

gatggcatgc ggagatcggg gtccatccag cagatggagc aactcaacag gcggtatcaa     2880

aacattcagc gaaccattgc aacagagagg tccgaagaag attctggcag ccaaagctgc     2940

gagcaagccc cagcaggagg aggcggaggt ggagggagtg actcagaagc cgaatcttcc     3000

cagtccagct tagatctaag gagagaaggg tcactttctc cagtgaactc acaaaaaatc     3060

accttgctgc tgcagtcccc agcggtcaag ttcatcacca accccgagtt cttcactgtg     3120

ctacatgcca attatagtgc ctaccgagtc ttcaccagta gcacctgctt aaagcacatg     3180

attctgaaag tccgacggga tgctcgcaat tttgaacgct accagcacaa ccgggacttg     3240

gtgaatttca tcaacatgtt cgcagacact cggctggaac tgccccgggg ctgggagatc     3300

aaaacggacc agcagggaaa gtcttttttc gtggaccaca acagtcgagc taccactttc     3360

attgaccccc gaatccctct tcagaacggt cgtcttccca atcatctaac tcaccgacag     3420

cacctccaga ggctccgaag ttacagcgct ggagaggcct cagaagtttc tagaaacaga     3480

ggagcctctt tactggccag gccaggacac agcttagtag ctgctattcg aagccaacat     3540

caacatgagt cattgccact ggcatataat gacaagattg tggcatttct tcgccagcca     3600

aacatttttg aaatgctgca agagcgtcag ccaagcttag caagaaacca cacactcagg     3660

gagaaaatcc attacattcg gactgagggt aatcacgggc ttgagaagtt gtcctgtgat     3720

gcggatctgg tcattttgct gagtctcttt gaagaagaga ttatgtccta cgtccccctg     3780

caggctgcct tccaccctgg gtatagcttc tctccccgat gttcaccctg ttcttcacct     3840

cagaactccc caggtttaca gagagccagt gcaagagccc cttcccccta ccgaagagac     3900

tttgaggcca agctccgcaa tttctacaga aaactggaag ccaaaggatt tggtcagggt     3960

ccggggaaaa ttaagctcat tattcgccgg gatcatttgt tggagggaac cttcaatcag     4020

gtgatggcct attcgcggaa agagctccag cgaaacaagc tctacgtcac ctttgttgga     4080

gaggagggcc tggactacag tggcccctcg cgggagttct tcttccttct gtctcaggag     4140

ctcttcaacc cttactatgg actctttgag tactcggcaa atgatactta cacggtgcag     4200

atcagcccca tgtccgcatt tgtagaaaac catcttgagt ggttcaggtt tagcggtcgc     4260

atcctgggtc tggctctgat ccatcagtac cttcttgacg ctttcttcac gaggcccttc     4320

tacaaggcac tcctgagact gccctgtgat ttgagtgacc tggaatattt ggatgaggaa     4380

ttccaccaga gtttgcagtg gatgaaggac aacaacatca cagacatctt agacctcact     4440

ttcactgtta atgaagaggt ttttggacag gtcacggaaa gggagttgaa gtctggagga     4500

gccaacacac aggtgacgga gaaaaacaag aaggagtaca tcgagcgcat ggtgaagtgg     4560

cgggtggagc gcggcgtggt acagcagacc gaggcgctgg tgcgcggctt ctacgaggtt     4620

gtagactcga ggctggtgtc cgtgtttgat gccagggagc tggagctggt gatagctggc     4680

accgcggaaa tcgacctaaa tgactggcgg aataacactg agtaccgggg aggttaccac     4740

gatgggcatc ttgtgatccg ctggttctgg gctgcggtgg agcgcttcaa taatgagcag     4800

aggctgagat tactgcagtt tgtcacggga acatccagcg tgccctacga aggcttcgca     4860

gccctccgtg ggagcaatgg gcttcggcgc ttctgcatag agaaatgggg gaaaattact     4920

tctctcccca gggcacacac atgcttcaac cgactggatc ttccaccgta tccctcgtac     4980

tccatgttgt atgaaaagct gttaacagca gtagaggaaa ccagcacctt tggacttgag     5040

tgaggacatg gaacctcgcc tgacattttc ctggccagtg acatcaccct tcctgggatg     5100

atcccctttt ccctttccct taatcaactc tcctttgatt ttggtattcc atgattttta     5160

ttttcaaac                                                             5169


<210> 3593
<211> 1945
<212> DNA
<213> Homo sapiens

<400> 3593
atggatttaa aggggcagta ccggcaagag cggcagccac accggcagat tgcagaccgg       60

gcaaggtccc ccaggccagg atgtcaggcc tggtgttggg gcagcgggat gagcctgcag      120

gccaccggct cagccaagag gagatcctgg ggagcacacg gctggtcagc caagggctag      180

aggccctacg cagtgaacac caggccgtgc tgcaaagcct gtcccagacc attgagtgtc      240

tgcagcaggg aggccatgag gaagggctgg tgcatgagaa ggcccggcag cttcgccgtt      300

ctatggaaaa cattgagctc gggctgagtg aggcccagga ggagaaagaa ggcgatgcca      360

ccaaggattc cctggatgac ctctttccta atgaggagga agaggacccc agcaatggct      420

tgtcccgtgg tcaaggtgct acagcagctc agcagggtgg atatgagatc ccagcaaggt      480

tgcggacgtt gcacaacctg gtgatccagt acgcagccca aggtcgctat gaggtggccg      540

tgccactctg taagcaggca ctagaggacc tggagcgcac atcaggccgt ggccaccctg      600

atgtcgccac catgctcaac atccttgctt tggtgtatcg tgaccagaat aagtataagg      660

aagctgccca cctgctgaat gatgccctta gcatccggga gagcaccttg ggacctgacc      720

atcctgctgt ggctgccaca ctcaacaatt tggctgtgct ctatggcaaa aggggcaagt      780

acaaggaggc agagcctctg tgccagcggg cactggagat tcgagaaaag gtcctgggca      840

cgaatcatcc agatgtggca aaacagctga acaacctggc cctcttgtgc caaaaccagg      900

gcaagtatga ggccgtggaa cgctactacc agcgagcact ggccatctac gaggggcagc      960

tggggccgga caaccctaat gtagcccgga ccaagaacaa cctggcttcc tgttacctga     1020

aacagggcaa atatgctgag gctgagacac tatacaaaga gatcctgacc cgtgcccatg     1080

tacaggagtt tgggtctgtg gatgatgacc acaagcccat ctggatgcat gcagaggagc     1140

gggaggaaat gagcaaaagc cggcaccatg agggtgggac accctatgct gagtatggag     1200

gctggtacaa ggcctgcaaa gtgagcagcc ccacagtgaa cactactctg agaaacctgg     1260

gagctctgta taggcgccag ggaaagctgg aggctgctga gaccctggag gaatgtgccc     1320

tgcggtcccg gagacagggc actgacccta tcagccagac gaaggtggca gagctgcttg     1380

gggagagtga tggtagaagg acctcccagg agggccctgg agacagtgtg aaattcgagg     1440

gaggtgaaga tgcttctgtg gctgtggagt ggtccgggga tggcagtggg accctgcaga     1500

ggagtggctc tcttggcaag atccgggatg tgctccgcag aagcagtgaa ctcttggtga     1560

ggaagctcca ggggactgag cctcggccct ccagcagcaa catgaagcga gcagcctcct     1620

tgaactatct gaaccaacct agtgcagcac ccctccaggt ctcccggggc ctcagtgcca     1680

gcaccatgga cctctcttca agcagctgac attcaacccg gcccccaggt ctgctgggtc     1740

cccccacccc cacagccctc acagcattcc ccattgctcc tggctcttcc ccacccctag     1800

gtgggacagt gaaggggagc agtttaacca gaagattgct gctgccctta gggtctcagc     1860

tccctcctca ggaatccctc ttaggaagga ccctcaggac accctctctg caccctgtgg     1920

tcctctagag tagctagctc tgagg                                           1945


<210> 3594
<211> 1721
<212> DNA
<213> Homo sapiens

<400> 3594
gccctcgcgc tgtcgccgcc acagtctgcg acgggacccg gcgtgcccat gtgtcaggtg       60

ggcgaggact acggggagcc ggcgcctgag gagccgcccc cggcgccgcg gcccagccgt      120

gagcagaagt gtgtgaagtg caaggaagcg cagcccgttg tggtgatacg agccggagat      180

gccttctgca gggactgttt caaggccttc tacgtccaca agttcagagc catgctgggc      240

aagaaccggc tcatctttcc aggcgagaag gtgctcttgg cgtggtctgg ggggccttcg      300

tccagctcca tggtctggca ggttcttgag ggcctgagcc aagattctgc caaaagactg      360

cgctttgtgg caggagtcat ctttgttgac gagggagcag cctgtggcca gagcctagag      420

gagagatcaa agaccctggc cgaagtgaag cccattctgc aagcaactgg gttcccatgg      480

catgtggtgg ccttagagga ggtgttcagc ctgccaccgt cggtgctttg gtgctctgcc      540

caggagctgg tgggatccga gggggcctac aaggcggccg tggacagctt cctccagcag      600

cagcatgtgc tgggggccgg gggtggtcct ggcccgactc aaggggagga acagccaccc      660

cagcccccgc tggaccccca gaacctggca agaccgcctg cccctgccca gactgaggct      720

ctttcccaac tgttctgctc agtgaggaca ctgactgcca aggaggagct tctgcagacc      780

ctgcggaccc acctgatcct ccacatggcc cgagcccacg gctactccaa ggtcatgact      840

ggggacagct gcacacgctt ggctatcaag ctcatgacca acctggcgct gggtcgaggg      900

gccttcctgg cctgggatac gggcttctcg gatgagcggc acggggacgt ggtggtggtg      960

cggcccatgc gggaccacac cctgaaggag gtcgctttct acaaccgcct gttctccgtt     1020

ccttctgtct tcacaccagc cgtcgacacc aaggcccctg aaaaggccag catccaccgg     1080

ctgatggagg ccttcatcct caggctgcag acccagttcc cctccactgt cagcactgtg     1140

tacaggacaa gtgagaagct ggtgaagggc ccccgggatg gccctgctgc tggcgactcc     1200

ggcccccgct gcctcctctg catgtgtgcc ctggacgtcg acgccgctga cagtgccacg     1260

gcttttgggg ctcagacctc ctcgcgtctc tcccagatgc agtcacccat ccccctgact     1320

gagacccgga cacccccggg gccctgctgt tctccagggg tgggctgggc ccagcgctgt     1380

ggccaggggg cctgcaggag ggaggacccc caagcctgca ttgaggagca gctgtgctac     1440

agctgccgcg tgaacatgaa ggacttgccc tcactggacc ccctgccgcc gtacatcctg     1500

gctgaggccc agctccgcac acagagggcc tggggcttgc aggagatccg ggactgtctg     1560

attgaggaca gtgacgacga ggcgggccag agctgagcgt gaggacgtgc ttgccgggac     1620

agcaggcagt ggccacctgg tacaccacac tggagccgga aggcaaggac gggggactgg     1680

cctctgattg tccatttgta taaataaaac attttttaat t                         1721


<210> 3595
<211> 2818
<212> DNA
<213> Homo sapiens

<400> 3595
cattgagtag gttcttgggg attggggtcg ggtcctcccc agtgagaggc gacaggagct       60

cactgcctct cgggccctca caatcacacc tgtcacaggt atacacgctg ccactcacaa      120

acacacgctt gcactcccag cctcactgac acgctgccat acagccgctc acagccagcc      180

agacactgct gcacctgaga gcaggtggcc gcgggtcttc tcccttcact ctccacattt      240

ggggatcagg tccggcacct gctgcgccag acaggccttg ctgggcacgc gcctctgaga      300

gtccaaggag gtggcttcca gagctgcagc acttcaggcc ggctccggtg gagcgatcag      360

aggtgagggg cttggctggg catgtttaag cgcacagtgc tctcctgccc acccccagca      420

gcacccccac tgcaggcccg aggagctttc cggagcttcc cacactcctg gggagaagac      480

ttcttagcca gcttgatgtt taaaattcag ctggagccct taaaacttcg agcgtggacg      540

ctgaatgggt ttgtaaagtt tcgaaacaag gagaccagtg ctggtccagt ggctgtgatg      600

ggaaaagatt attacaagat tcttgggatc ccatcggggg ccaacgagga tgagatcaag      660

aaagcctacc ggaagatggc cttgaagtac cacccagaca agaataaaga acccaacgct      720

gaggagaagt ttaaggagat tgcagaggcc tatgatgtgc taagtgaccc caagaaacgg      780

ggcctgtatg accagtatgg ggaggaaggc ctgaagaccg gcggtggcac atcaggtggc      840

tccagtggct cctttcacta cacctttcat ggggaccccc atgccacctt tgcctccttc      900

tttggtggct ccaacccctt cgatatcttc tttgccagca gccgctccac tcggcccttc      960

agtggctttg acccagatga catggatgtg gatgaagatg aggacccatt tggcgctttc     1020

ggccgttttg gcttcaatgg gctgagtagg ggtccaaggc gagccccaga accactgtac     1080

cctcggcgca aggtgcagga ccccccagtg gtgcacgagc tgcgggtgtc cctggaggag     1140

atctaccatg gctccaccaa gcgcatgaag atcacaaggc gtcgcctcaa ccctgatggg     1200

cgaactgtgc gcaccgagga caagatcctg cacatagtca tcaagcgtgg ctggaaggaa     1260

ggcaccaaga tcaccttccc caaagaaggc gacgccacac ctgacaacat ccctgctgac     1320

atcgtctttg tgctcaaaga caagccccat gcacacttcc gccgagatgg caccaacgtg     1380

ctctacagtg ccctgatcag cctcaaggag gcgctgtgtg gctgcactgt gaacattccc     1440

actatcgacg gccgagtgat ccctttgccc tgcaatgatg tcatcaagcc aggcaccgtg     1500

aagagactcc gtggggaggg ccttcccttc cccaaagtgc caactcagcg aggagacctc     1560

attgttgagt tcaaagttcg cttcccagac agattaacac cacagacaag acagatcctt     1620

aagcagcacc taccctgttc ctaggctctg ccccagccag tccagagcct accacagcaa     1680

tacccccaac actcactcca ctcaatgtgc acccagcttg atgtccactg gacactggca     1740

actttttcta aaatgcaaaa aaaagccact ggttttcagg aaaatgttcc tgtccctgac     1800

cccttttaga gctgggctgc ctggggggag tgggagggag gtggggagag ctagcccagg     1860

ccaggggtca atgttcatgt cactagcttt caatccagtt tccactgcag tggctggaga     1920

gtgacctgag tgctacttga agatatgtag agattcctta tccatgcctg tacatagcat     1980

gtcctcctcc cctcagcttt gctaatacca gtcccctccc ttccctttgg cttcctgctg     2040

ttgggggtgg aaaagactag aaaggacatt gctttctcag ccccaccccc aggtccacag     2100

tgtccaaggt aatggcacac atattcatgc acaagaagca ctcacctaga gctgtctgtg     2160

cctctctggg agaaaggaga gaggataaga agggaaagtt cacaacctgt gaacagggac     2220

ttgagcacga gacacttttc atctggagca ggggggtgag ctcctcagca gcctccgtaa     2280

cagctgccct gcctacacct gcagagctgg aggttctgtc ctccctgctg ctctcaggag     2340

tgttcaaggg tggagggcag ggaatggggc ctgaggtatt aaggctaaga ggtgggggac     2400

agggcccatc taccagcctt catcaggaag ggaaagggct ttggggtcag gtggcagcta     2460

ttccccacca agagattcag ggtcacaggt ttttccccac acctctgaac tcagggccta     2520

gccaccccca aacttccaaa tcccactttt gtgatatgtg aagctactca tttcttaccc     2580

ttggaggctg tgtggggaat ttccagccct tttatgcctg tgtgatccca ccccaccccc     2640

atagttgtat aaaggtcata gtgaagaagc tgggggaaga ctgcttcagc cagatcctgg     2700

ggtggggtct ttaggttttc tcactttgac aacccccgaa tgtttttata gtagtttttt     2760

tgtatttttt tgtaatgaca gtattatgta aaaaataaag tattttaaaa atatggca       2818


<210> 3596
<211> 9444
<212> DNA
<213> Homo sapiens

<400> 3596
gtgctgtggc ggcggcggcg gcggtagtgg cggcggcggc ggtgcctggg cggcagcagc       60

agcagtagcg gcagccctga ggacggtgag acggccgcgg cggcggcgac agcgcggaag      120

tcgcgcggga cccagagctt cccccctgtc gctagtgctg aggctttcgc ctttcctacc      180

cagcttcttg ctcacggccc gggctgggct gggcagggca acgcgccccc ggggaggggc      240

ggagctgtag atatggtgta agatacttct tcaagattgg acagctgggg accttcttct      300

gattaacctt aaaccaactt gtagccatag agacacctca caaggttccc atttttgttg      360

ttgttgttgt tgattttctg ctcacacctt tcctgacctt gcaaccatgt atggaagtgc      420

ccgctctgtt gggaaggtgg agccgagcag ccagagccct gggcgttcac ccaggcttcc      480

acgttcccct cgcttgggtc accgtcgaac caacagtacg ggagggagtt cgggaagcag      540

tgttggaggt ggcagtggga aaaccctttc aatggaaaat atacaatctt taaatgctgc      600

ctatgccacc tctggcccta tgtatctaag tgaccatgaa aatgtgggtt cagaaacacc      660

taaaagcacc atgacacttg gccgttctgg gggacgtctg ccttacggtg ttcggatgac      720

tgctatgggt agtagcccca atatagctag cagtggggtt gctagtgaca ccatagcatt      780

tggagagcat cacctccctc ctgtgagtat ggcatccact gtacctcact cccttcgtca      840

ggcgagagat aacacaatca tggatctgca gacacagctg aaggaagtat taagagaaaa      900

tgatctcttg cggaaggatg tggaagtaaa ggagagcaaa ttgagttctt caatgaatag      960

catcaagacc ttctggagcc cagagctgaa gaaggaacga gccctgagaa aagatgaagc     1020

ttccaaaatc accatttgga aggaacagta cagagttgta caggaggaaa accagcacat     1080

gcagatgaca atccaggctc tccaggatga attgcggatc cagagggacc tgaatcagct     1140

gtttcagcag gatagtagca gcaggactgg cgaaccttgt gtagcagagc tgacagagga     1200

gaactttcag aggcttcatg ctgagcatga gcggcaggcc aaagagctgt ttcttcttcg     1260

aaagacattg gaggaaatgg agctgcgtat tgagactcaa aagcagaccc taaatgctcg     1320

ggatgaatcc attaagaagc ttctggaaat gttgcagagc aaaggacttt ctgccaaggc     1380

taccgaggaa gaccatgaga gaacaagacg actggcagag gcagagatgc acgttcatca     1440

cctagaaagc cttttggagc agaaggaaaa agagaacagt atgttgagag aggagatgca     1500

tcgaaggttt gagaatgctc ctgattctgc caaaacaaaa gctctgcaaa ctgttattga     1560

gatgaaggat tcaaaaattt cctctatgga gcgtgggctt cgagacctgg aagaggaaat     1620

tcagatgctg aaatcgaatg gtgctttgag tactgaggaa agggaagaag aaatgaagca     1680

aatggaagtg tatcggagcc attctaaatt tatgaaaaat aagattggcc aggtgaaaca     1740

ggagctgtcc agaaaggaca cagaactact cgccctgcag acaaagctag aaacactcac     1800

aaaccagttc tcagatagta aacagcacat tgaagtgttg aaggagtcct tgactgctaa     1860

ggagcagagg gctgccatcc tgcagactga ggtggatgct ctccgattgc gtttggaaga     1920

gaaggaaacc atgttgaata aaaagacaaa acaaattcag gatatggctg aagagaaggg     1980

gacacaagct ggagagatac atgacctcaa ggacatgttg gatgtgaagg agcggaaggt     2040

taatgttctt cagaagaaga ttgaaaatct tcaagagcag cttagagaca aggaaaagca     2100

gatgagcagc ttgaaagaac gggtcaaatc cttgcaggct gacaccacca acactgacac     2160

tgccttgaca actttggagg aggcccttgc agagaaagag cggacaattg aacgcttaaa     2220

ggagcagagg gacagagatg agcgagagaa gcaagaggaa attgataact acaaaaaaga     2280

tcttaaagac ttgaaggaaa aagtcagcct gttgcaaggc gacctttcag agaaagaggc     2340

ttcacttttg gatctgaaag agcatgcttc ttctctggca tcctcaggac tgaaaaagga     2400

ctcacggctt aagacactag agattgcttt ggagcagaag aaggaggagt gtctgaaaat     2460

ggaatcacaa ttgaaaaagg cacatgaggc agcattggaa gccagagcca gtccagagat     2520

gagtgaccga atacagcact tggagagaga gatcaccagg tacaaagatg aatctagcaa     2580

ggcccaggca gaagttgatc gactcttaga aatcttgaag gaggtggaaa atgagaagaa     2640

tgacaaagat aagaagatag ctgagttgga aagccttttt tctaggcaag tgaaagacca     2700

gaataagaag gtagcaaatc tgaagcacaa ggaacaggtg gaaaaaaaga agagtgcaca     2760

aatgttagag gaggcgcgac gacgggagga caatctcaac gacagctctc agcagctaca     2820

ggacagtctc cgtaagaagg atgacaggat tgaagagctg gaagaagcac taagagaaag     2880

tgtacagata actgcagagc gggaaatggt gctagcacaa gaggaatcag ccaggaccaa     2940

tgctgaaaaa caggtggagg agttactgat ggccatggag aaggtaaagc aggaactaga     3000

atccatgaaa gcaaagctgt cctccaccca gcagtctctg gcagaaaagg aaactcactt     3060

gactaatctt cgggcagaga gaaggaaaca cttagaggaa gttctggaga tgaagcaaga     3120

agctcttctg gctgccatta gtgaaaaaga cgccaatata gctctcttgg agctttcgtc     3180

ctctaagaag aagacccaag aggaagtggc tgccctgaag cgggagaagg atcgtctggt     3240

acagcagctt aagcagcaga cgcaaaatcg aatgaagcta atggccgaca actacgagga     3300

tgaccacttc aaatcctccc attccaatca aacaaatcac aagccctccc cagaccagga     3360

tgaggaggag ggtatatggg catagccaat cagaggctta gttcagccat tttgttcaga     3420

acgatcatcc agcccctctt agaacttgac caaaatagaa gtaaattaaa gttgtacatt     3480

ggacacctga caaccctctg ccatgaccga gaccccctga tcctccgtgg actcactcca     3540

ccagcttcct ataacttgga cgatgaccag gcggcttggg agaatgagct gcagaagatg     3600

acccgggggc agcttcagga tgagttagag aaaggtgaac gggacaatgc agaactgcag     3660

gagtttgcca acgccattct tcagcagata gcagaccatt gtcccgacat cctagagcaa     3720

gtggtcaacg ccctggaaga gtcctcttga ccctgcttta tggggaagcc tgaggtagtc     3780

aacccaggag ccaagaaaag agaactacga ggaacaggtg cccggaacct tcttggcacc     3840

aaacactaca aacttcatcc caacttgctc acttgaagaa gtgtgattcc agcaccgttt     3900

ctacatctgc catcttactc tgcctttctg ctttggatgt ggtctctaca ctaaccttct     3960

tgatgtccag ggtagataaa gggtcgaatc tctctgaaga actgccacct ggtcatcagc     4020

agtggagaac tgtgggagct ggtggctctg ccctgacaga gagccatgga gcagaggagc     4080

ctctcacctc ctgtcctctg acatgagaat gaaaccagga atggacttgg agttcaacag     4140

gctgagagga tgcctccaat ggaccagaga gctgagtgtt ctaatatcac aataggtgct     4200

ttctcctaaa agggcaaaaa acaatctcaa aaagattaga aaaagagaag gggggaaggg     4260

aagagaaaat cgactcttct ttttactgtc tcttctgctt actttccaca tgagatgctt     4320

tgtaccgggg agctgtgagc aggcctcacg atggcttggg agcactcgtt ctcccaaggt     4380

ctgagtcttc atccagccct gcctgtctgt cgcagccttc ctcactctgt tcctcggcca     4440

gttaacaaga agatggtgtg aggtgttctc caccagtctc tcctgtttga gactgttgac     4500

gttatcatac tgaggtgtta gatcaaatat ctctaattga agaacatgtg aggttgaaag     4560

agcaccagcc agggcaacat agcgtgaccc tgtctctaca aaaaattaaa aagagaacat     4620

acaaagttga catatgagac cctgttgtcc ccgcctgcag ctttgcccca gtaacagatg     4680

cccgttgctc ttgggctggt ttcccctgaa cacctccaag aggctgcctg ccttgccagc     4740

acccgtgtcc tgagctcctg cagcccagtg gctgctgaag ttgtgatccc tcactcaccc     4800

tgctagcttt gcccttgact cgtcttctct gaacctcagc ctcgtgcatt gcctggaacc     4860

ttcttctagc ataaatgaag gtttttcctc ctacacacat tccttcctcg gttatttcat     4920

tcagagaata tttatgaaat gcctactgtg tgcaagtcat ccatccttga aaaggccact     4980

tctcagtgag ggagagatgt agtggattct gtgagacata cctgctggag ttgaagcagt     5040

aaatagcatg tccttcccct ccccgatctt aaggtgtgtt ttctagaaaa gttccctaat     5100

ggaattcatg agtttggggg tctcagtcac ccgcttgcct gtaggattcc atttgatgat     5160

tctggatttt tgctgtttgt tattgccctt agaggggctc tgagtatcta cttgtgggtg     5220

gccatttcct gacatctgca tgtacctcgt ggaattcagc cagcttcatg ttgcaaatca     5280

gaaagctgac cccaagactg caaatcaatg aaggtattgg cattgttaag gacgtagcgt     5340

agacaacagc agtcataaat aattaggcag gaacttaacc caaatctagt tctttgacca     5400

cctctaccac cagaacccag cagacactca catctcctga taagagttgc tggactcgat     5460

gtttttgttt tgcattttct cctctccttc cccacttact cagagaattt aaagtctgta     5520

gagtcagcac agccccatca gtccaggaac ttcccaccac cagcccttga ctgtcccatt     5580

aactgacatg gtcagatttc cagctccccc tactccctgc tgtgaaacaa tccctctccc     5640

tgtgagagga aactgtggag cgtttcttat cgaaggttaa atggactctg ctcataaacc     5700

tcttactgag atgcttcctg atagccaggc tggccagaga ggggtgcagg ggttagatag     5760

taagtggtgg tcgtttgtgg tcagttacct caattctgtt cattgcagtg cccgtaaacc     5820

atgtagaaag ctcccagcac tgaaaggcag gagtgttagc atctcgcttt atccaccata     5880

acgtaaagaa ctgcggtgtg ataacagcct tcacggggcc acggtggaac caagacagca     5940

ggcgaggcca tgcctaaaca agtggtctgg cacgggcact ggccagctgc tctctccaag     6000

caggtggccc agatcccacc cacgtggact ttctcatcag gtgcagcgcc tgccactctc     6060

agccactggg tgtgtcactc tcctcttcat ctcagcattc tccatcactt cccctccaga     6120

aaaacggatg gaaggaagcc ctctgtgaca ctgcttctga gaagaagcat ttccgggacc     6180

gatatcatct gtctggtctc tgtgaacagc aaggaatctt cttgaccgtt cttgggcact     6240

ggaggctggc taggagttca gtaataaacg tggccttcgt gctgtagggc agagtggatg     6300

cagtttgtag ctttcagagt gtctcattga gtctagatca ttgaaccaac acttaaccaa     6360

atgtcccact cccatcacac taggacttgt cattccatgc ccctctccta gtggtcatgg     6420

tttcatatgg gcatacaact gctactgaag ttatatagcc ttgaaaactc agtgcaggtt     6480

gcccttaatt ttccccaaac ccctccatcg gcaagtctag ttgcccttta gcacctaaag     6540

atctgcaccc caaaccaatg tcaccataaa gagggcacga agaagagtgg gtgtgatccc     6600

aacggggttt tgtaactgaa gaagcccagt gtgagcttct catcttttca tatacctcta     6660

acccccggta ctcattgaat cattgatgag gtatctcaat tgagatttgc aaggactttg     6720

ataccatttg aaatggaaaa attttgaacg ggctttaaca tgtttaagaa atatggatgg     6780

ggccggccac agtggctcac gcctgtaatc ccagaactct ggaaggctga ggcaggcgga     6840

tcacctgaga tcaggagttc gaggccagcc tggccaagat ggcaaaaacc ccgactctac     6900

taaaaataca aaattagcca ggcgtggtgg cgtacgcctg taatcccagc tactcaggag     6960

gcaggagaat cgcttgagcc tgggaggcag aggctgcggt gagccgagat cgtgtcactg     7020

cactccagcc tgggtgacag agactccatt taaaaaaaaa aaaaaaaaat atatatatat     7080

atatatatat atatatatgg atgggaatca ccaaattcat ctcagctcta accttttaac     7140

ctttgtcctt gcactttaca atctaaagat ctacctgtgg ctctcagact tcctcacact     7200

tgggttttag aaataacttg taaagcagac tggacccaag gccgccttca gtgtcaagaa     7260

gggcattgtg acttgcccct caatttctgt ccattgaagt ctggttttcc atgaggaact     7320

tgcgggctca cccaccccca gagtgagaga agaggaaggc gaagtcatca cagacacggt     7380

cttagccacc tgctgaacta atccctccgc tattgagggt cagggttgtg aggcaaccat     7440

catgtgtcac cccaaaatat aaatgtttct gagccgccca tccactggca tttggatttg     7500

ctgccagagt cctgttcctc ccagaaccat cccgccctcc tgttgaccat gttacttgag     7560

tgtaggcccg gtgtcaagac cctcagagtc tttgaggaaa gagccaagca gagaagaccg     7620

ctgcgtggag tgtgacacca catggcattt ctcaagccca gcggaccctg tgtcagcaaa     7680

taccagtaat ttaacatctg ctcctggcct cctcttcacc tgcctgggtt cggaactgag     7740

gaggaaggat gagaagagac tgcaatgcag caggcaccct ctgcagagtg aggccgcccg     7800

tccatcactg ccagccctgg gctgctcagg aggggacgtg aaccactcaa aggaatgtct     7860

taaagaggat ctggagtttc ccccatgcaa attagggaag aattaggcaa gaaaagacat     7920

acattacagg gaaatccttc tgaacaaaat ggctgtcttc acctactctt cttgcaagaa     7980

aagacataca ttacagggaa atccttctga acaaaatggc tatcttcacc tactcttcag     8040

caaaaaccgt ctccagactt tttagtgtca aaaatgtaac caactgtctc ctgatttttt     8100

ccaatgtgtt tggcaagtgc tgtggccctg ttgtaggtac ttctcctgac tcttggggga     8160

gaagtggttt tagggattga tttgggggag cgggtttttg tcccatccca cctcctctct     8220

tctttctctg cttgtcgata ttgtctgtgt gattcagaga attggggcag ttacattgtg     8280

tctgttgttg agattattaa aagattaaaa cgtagttgta gaaatgaaaa attaaacagc     8340

tgtgttttaa aaatgcaaac caatatcttg ttaataaagg aattcaagct atggggcagc     8400

cacactcccc tcctcccagg ctggcatagg tggccctggg ctggcggctt aggaagcatg     8460

gagcacactt agggtagtgc ctgcctgggc aagagacacc tgccgagcaa aaggaacgag     8520

aatctggggc tcagagcctc gcagttgtgc caggattttc ctatacatgt tcaggacctc     8580

tgggtagagg tttcacagtt tgtgacccca taaccaccct cacccgacgt gggttctagc     8640

tcagtgtgcc taatactgca tggtaacctg ggcttgaccc tgaagcccct gcctggcagg     8700

ccacaggacc tctcctgccc acttggtgct atctcttcca gtgaccaccc agcacgggtg     8760

agcactggcc agcctggagc ctgcaatcca ggtggaacag actgtcctcc atgtcagttc     8820

cttctggctt caggccctca attatttccc tttgagcttt tttagaccct agatctccta     8880

ggcccaggct ctctcttgac cccagagaag ccactgtcag gaaaggaagt gaaccctact     8940

gaagccagag aattcacccc ggccaaagca ggccctctgg gtccagcccc tcattccaca     9000

ccacgccagt attgcatcca tctactgcag ctacacatcc tgagggcagc accacccact     9060

ctggcctgct ggcccatcgc aggactagcc caggcacctg ccgggcattg caggatatcc     9120

agtggggcct gtgactgctc cctgatgcgt cagaagagaa gtgttgcact ttagtggagg     9180

agctgaggag cacctgcccc cttgtagctt gagttccttt tggtaacagt agcagcctcc     9240

atggtggtgt ctgggatgca cgtgcacccg ctgccttcag ctgtatgtgt gtgttcctgc     9300

tggagttgtg ttactgacag gataatgaca ttacaaagaa attgtgttat attcaacttt     9360

gccttgataa ttattgtaaa cactttgttc attttttctt ttttattcac aaactaaatc     9420

caccaggaaa ttataaagtt attt                                            9444


<210> 3597
<211> 716
<212> DNA
<213> Homo sapiens

<400> 3597
aaagggtctg tccttcctgg gattcctagc cgaggccagt ctgctgccgt gtgcgtgtgc       60

gtcagggctc tccgggcggc aatgggggct tgagagccgg gtccccagcg ccgggaaggg      120

agcgcggtgg ccgccaccgc caccgccccg gagtccggcg ccgaagctgc gggcgggcgg      180

gcgggcacca gctcggtcag gggctgcttg gcgcggcact gtgcggtgca gcggcggcgc      240

ggcgcggtgc gggcttttcc caggcgcccc ggggtcgggt ggccaacggc gcggccgcgg      300

gcgctgagcg cgaccggttc gcggtagcgg tggcggcggc gtgcgtgcca ggggctgggg      360

gctccgccgc ctctcttgcg gctcaccgag ctccgcgctt ccctctctcc agggcaggcg      420

gcttctcaga gttttcaggt ggcgaaactg actggtctgg ttagagcgcg tccaagccaa      480

gccgcagtgc tgtttggatt tttaaatttc tccttctgag tgagaaaata gcaatcgaga      540

tggaaccatc cgcacaacag ctccagctgg cagcatcact tcccgccaat ttatccaact      600

tctgccaagg ctctgaaatg ccaacaacgt cgaggcctgc acttgatgtc aagggtggca      660

cctcacctgc gaaggaggat gccaaccaag agatgagctc cgtggcctac tccaac          716


<210> 3598
<211> 7006
<212> DNA
<213> Homo sapiens

<400> 3598
gttttgatga acacctggct ttattcttgc aatgaagaaa ggttctcaac aaaaaatatt       60

ctccaaagca aagataccat catcatctca ctctcctatc ccatcatcta tgtccaatat      120

gagatctagg tcactttcac ctttgattgg atcagagact ctaccttttc attctggagg      180

acagtggtgt gagcaagttg agattgcaga tgaaaacaat atgcttttgg actatcaaga      240

ccataaagga gctgattcac atgcaggagt tagatatatt acagaggccc tcattaaaaa      300

acttactaaa caggataatt tggctttgat aaaatctctg aacctttcac tttctaaaga      360

cggtggcaag aaatttaagt atattgagaa tttggaaaaa tgtgttaaac ttgaagtact      420

gaatctcagc tataatctaa tagggaagat tgaaaagttg gacaagctgt taaaattacg      480

tgaactcaac ttatcatata acaaaatcag caaaattgaa ggcatagaaa atatgtgtaa      540

tctgcaaaag cttaaccttg caggaaatga aattgagcat attccagtat ggttagggaa      600

gaagttaaaa tctttgcgag tcctcaattt gaaaggcaac aagatatcat cgctccaaga      660

tataagcaag ttgaaaccgc ttcaagattt gatttctctg atcctagttg aaaatccagt      720

tgtgaccctt cctcattacc tccagtttac cattttccac ctccgttcat tggaaagttt      780

ggaaggtcag ccagtaacca ctcaggatag acaggaggct tttgagagat tcagtttaga      840

agaggtagaa agactggaaa gagacctaga aaaaaagatg atagaaactg aagagcttaa      900

gagcaaacaa acaaggttcc ttgaggaaat taaaaatcaa gataaattga ataaatcatt      960

aaaagaggag gccatgttac agaaacagag ctgtgaggaa ctcaagagtg acttaaacac     1020

aaaaaatgaa ttgctaaaac agaagaccat agaattaaca cgagcatgtc agaagcaata     1080

tgagctggaa caggaattgg ccttttataa aattgatgct aaatttgagc cactaaatta     1140

ttatccatca gagtatgctg aaattgataa agccccagat gaaagccctt acattggcaa     1200

atccagatac aagagaaata tgtttgccac agagagttat attattgaca gtgctcaggc     1260

agtacagatc aagaagatgg agccagatga acaacttaga aatgatcaca tgaacttgag     1320

aggccacaca ccactggaca cgcaactgga agacaaagaa aaaaaaataa gtgcagcaca     1380

aactcgacta tcagaactgc atgatgaaat agaaaaggca gaacaacaaa ttttgagagc     1440

tactgaagaa tttaaacaac tggaagaagc tatacaacta aaaaagattt cagaagcagg     1500

gaaagacctt ctttacaagc agttgagtgg tagactacaa cttgtaaata aattacgcca     1560

ggaagctctg gatctagaac tgcagatgga aaagcaaaag caggaaattg ccggaaagca     1620

gaaggagatt aaggacctgc aaatagccat agatagcctg gattccaaag acccaaaaca     1680

ttcccatatg aaggctcaaa agagcggtaa agaacaacag cttgacatta tgaacaagca     1740

gtaccaacaa cttgaaagtc gtttggatga gatactttct agaattgcta aggaaacgga     1800

agagattaag gaccttgaag aacagcttac tgaaggccag atagcagcaa atgaagccct     1860

gaagaaggat ttagaaggtg ttatcagtgg gttgcaagaa tacctgggga ccattaaagg     1920

ccaggcaact caggcccaga atgagtgcag gaagctgcgg gatgagaaag agacattgtt     1980

gcagagattg acagaagtcg agcaggagag agaccagctg gaaatagttg ccatggatgc     2040

agaaaatatg aggaaggagc ttgcagagct agaaagtgcc ctccaagagc agcatgaggt     2100

gaatgcatct ttgcagcaga cccagggaga tctcagtgcc tatgaagctg agctagaggc     2160

tcggctaaac ctaagggatg ctgaagccaa ccagctcaag gaagagttgg aaaaagtaac     2220

aagacttacc cagttagaac aatcagccct tcaagcagaa cttgagaagg aaaggcaagc     2280

cctcaagaat gcccttggaa aagcccagtt ctcagaagaa aaggagcaag agaacagtga     2340

gctccatgca aaacttaaac acttgcagga tgacaataat ctgttaaaac agcaacttaa     2400

agatttccag aatcacctta accatgtggt tgatggtttg gttcgtccag aagaagtggc     2460

agctcgtgtg gatgagctaa gaagaaaact gaaattagga actggggaaa tgaacatcca     2520

tagtccttca gatgtcttag ggaaaagtct tgctgattta cagaaacaat tcagtgaaat     2580

tcttgcacgc tccaagtggg aaagagatga agcacaagtt agagagagaa aactccaaga     2640

agaaatggct ctgcagcaag agaaactggc aactggacaa gaagagttca ggcaggcctg     2700

tgagagagcc ctggaagcaa gaatgaattt tgataagagg caacatgaag caagaatcca     2760

gcaaatggag aatgaaattc actatttgca agaaaatcta aaaagtatgg aggaaatcca     2820

aggccttaca gatctccaac ttcaggaagc tgatgaagag aaggagagaa ttctggccca     2880

actccgagag ttagagaaaa agaagaaact tgaagatgcc aaatctcagg agcaagtttt     2940

tggtttagat aaagaactga agaaactaaa gaaagccgtg gccacctctg ataagctagc     3000

cacagctgag ctcaccattg ccaaagacca gctgaagtcc cttcatggaa ctgttatgaa     3060

aattaaccag gagcgagcag aggagttgca ggaagcagag aggttcagca gaaaggcagc     3120

acaagcagcc agagatctca cccgagcaga agctgagatc gaactcctgc agaatctcct     3180

caggcagaag ggggagcagt ttcgacttga gatggagaaa acaggtgtag gtactggagc     3240

aaactcacag gtcctagaaa ttgagaaact gaatgagaca atggaacgac aaaggacaga     3300

gattgcaagg ctgcagaatg tactagacct cactggaagt gacaacaaag gaggctttga     3360

aaatgtttta gaagaaattg ctgaacttcg acgtgaagtt tcttatcaga atgattacat     3420

aagcagcatg gcagatcctt tcaaaagacg aggctattgg tactttatgc caccaccacc     3480

atcatcaaaa gtttccagcc atagttccca ggccaccaag gactctggtg ttggccttaa     3540

gtactcagcc tcaactcctg ttagaaaacc acgccctggg cagcaggatg ggaaggaagg     3600

cagtcaacct ccccctgcct caggatactg ggtttattct cccatcagga gtgggttaca     3660

taaactgttt ccaagtagag atgcagacag tggaggagat agtcaggaag agagtgagct     3720

ggatgaccaa gaagaacccc catttgtgcc tcctcctgga tacatgatgt atactgtgct     3780

tcctgatggt tctcctgtac cccagggcat ggccctgtat gcaccacctc ctcccttgcc     3840

aaacaatagc cgacctctca cccctggcac tgttgtttat ggcccacctc ctgctggggc     3900

ccccatggtg tatgggcctc caccccccaa cttctccatc cccttcatcc ctatgggtgt     3960

gctgcattgc aacgtccctg aacaccataa cttagagaat gaagtttcta gattagaaga     4020

cataatgcag catttaaaat caaagaagcg ggaagaaagg tggatgagag catccaagcg     4080

gcagtcggag aaagaaatgg aagaactgca tcataatatt gatgatcttt tgcaagagaa     4140

gaaaagctta gagtgtgaag tagaagaatt acatagaact gtccagaaac gtcaacagca     4200

aaaggacttc attgatggaa atgttgagag tcttatgact gaactagaaa tagaaaaatc     4260

actcaaacat catgaagata ttgtagatga aattgagtgc attgagaaga ctcttctgaa     4320

acgtcgctca gagctcaggg aagctgaccg actcctggca gaggctgaga gtgaactttc     4380

atgcactaaa gaaaagacaa aaaatgctgt tgaaaagttc actgatgcca agagaagttt     4440

attgcaaact gagtcagatg ctgaggaatt agaaaggaga gctcaggaaa ctgctgttaa     4500

cctcgtcaaa gctgatcagc agctaagatc gctccaggct gatgcaaagg atttggagca     4560

gcacaaaatc aagcaagaag aaatcttgaa agaaataaac aaaattgtag cagcaaaaga     4620

ctcagacttc caatgtttaa gcaagaagaa ggaaaaactg acagaagagc ttcagaaact     4680

acagaaagac atagagatgg cagaacgcaa tgaggatcac cacctgcagg tccttaaaga     4740

atctgaggtg cttcttcagg ccaaaagagc cgagctggaa aagctgaaaa gccaggtgac     4800

aagtcagcag caggagatgg ctgtcttgga caggcagtta gggcataaaa aggaggagct     4860

gcatctactc caaggaagca tggtccaggc aaaagctgac ctccaggaag ctctgagact     4920

gggagagact gaagtaactg agaagtgcaa tcacattagg gaagtaaaat ctcttctgga     4980

agaactgagt tttcagaaag gagaactaaa tgttcagatt agtgaaagaa aaactcaact     5040

tacacttata aagcaggaaa ttgaaaaaga ggaagaaaat cttcaggttg ttttaaggca     5100

gatgtctaaa cataaaaccg aactaaagaa tattctggac atgttgcaac ttgaaaacca     5160

tgagctacaa ggtttgaagc tacaacatga ccaaagggta tctgaattag agaagactca     5220

ggtggcagtg ctagaggaga aactggagtt agagaatttg cagcagatat cccagcagca     5280

gaaaggggaa atagagtggc agaagcagct ccttgagagg gataaacgag aaatagaacg     5340

aatgactgct gagtcccgag ctttacaatc gtgtgttgag tgtttgagca aagaaaagga     5400

agatctccaa gagaaatgtg acatttggga aaaaaagttg gcacaaacca aaagggtttt     5460

agcagcagca gaagaaaata gcaaaatgga gcaatcaaac ttagaaaagt tggaattgaa     5520

tgtcagaaaa ctgcagcagg aactagacca actaaacaga gacaagttgt cactgcataa     5580

cgacatttca gcaatgcaac agcagctcca agaaaaacga gaagcagtaa actcactgca     5640

ggaggaacta gctaatgtcc aagaccattt gaacctagca aaacaggacc tgcttcacac     5700

caccaagcat caggatgtgt tgctcagtga gcagacccga ctccagaagg acatcagtga     5760

atgggcaaat aggtttgaag actgtcagaa agaagaggag acaaaacaac aacaacttca     5820

agtgcttcag aatgagattg aagaaaacaa gctcaaacta gtccaacaag aaatgatgtt     5880

tcagagactc cagaaagaga gagaaagtga agaaagcaaa ttagaaacca gtaaagtgac     5940

actgaaggag caacagcacc agctggaaaa ggaattaaca gaccagaaaa gcaaactgga     6000

ccaagtgctc tcaaaggtgc tggcagctga agagcgtgtt aggactctgc aggaagagga     6060

gaggtggtgt gagagcctgg agaagacact ctcccaaact aaacggcagc tttcagaaag     6120

ggagcagcaa ttggtggaga aatcaggtga gctgttggcc ctccagaaag aggcagattc     6180

tatgagggca gacttcagcc ttctgcggaa ccagttcttg acagaaagaa agaaagctga     6240

gaagcaggtg gccagcctga aggaagcact taagatccag cggagccagc tggagaaaaa     6300

ccttcttgag caaaaacagg agaacagctg catacaaaag gaaatggcaa caattgaact     6360

ggtagcccag gacaaccatg agcgggccag gcgcctgatg aaggagctca accagatgca     6420

gtatgagtac acggagctca agaaacagat ggcaaaccaa aaagatttgg agagaagaca     6480

aatggaaatc agtgatgcaa tgaggacact taaatctgag gtgaaggatg aaatcagaac     6540

cagcttgaag aatcttaatc agtttcttcc agaactacca gcagatctag aagctatttt     6600

ggaaagaaac gaaaacctag aaggagaatt ggaaagcttg aaagagaacc ttccatttac     6660

catgaatgag ggaccttttg aagaaaaact gaacttttcc caagttcaca taatggatga     6720

acactggcgt ggagaagcac tccgggagaa actgcgtcac cgggaagacc gactcaaggc     6780

ccaactccga cactgtatgt ccaagcaagc agaagtatta attaaaggaa agcggcagac     6840

agagggcact ttacacagtt tgaggagaca agtagatgct ttaggggaat tggtcaccag     6900

cacctctgca gattcagcgt catcacccag tctgtctcag ctggagtctt ccctcacaga     6960

ggactctcaa cttggacaaa atcagaaaca aaacaatagc ctgagg                    7006


<210> 3599
<211> 1268
<212> DNA
<213> Homo sapiens

<400> 3599
ggtgaaaggt gaggggaaca gctgatccgt ctgttgggag gacagatatc tcaaggccag       60

gatggaagaa tcaccactaa gccgggcacc atcccgtggt ggagtcaact ttctcaatgt      120

agcccggacc tacatcccca acaccaaggt ggaatgtcac tacacccttc ccccaggcac      180

catgcccagt gccagtgact ggattggcat cttcaagcca gctacctgcc caaaccagga      240

gctcagctct accagttccg atatgtgaac cgccagggcc aggtgtgtgg gcagagcccc      300

cctttccagt tccgagagcc aaggcccatg gatgaactgg tgaccctgga ggaggctgat      360

gggggctctg acatcctgct ggttgtcccc aaggcaactg tgttacagaa ccagctcgat      420

gagagccagc aagaacggaa tgacctgatg cagctgaagc tacagctgga gggacaggtg      480

acagagctga ggagccgagt gcaggagctc gagagggctc tggcaactgc caggcaggag      540

cacacggagc tgatggaaca gtacaagggg atttcccggt cccatgggga gatcacagaa      600

gagagggaca tcctgagccg gcaacaggga gaccatgtgg cacgcatcct ggagctagag      660

gatgacatcc agaccatcag tgagaaagtg ctgacgaagg aagtggagct ggacaggctt      720

agagacacag tgaaggccct gactcgggaa caagagaagc tccttgggca actgaaagaa      780

gtacaagcag acaaggagca aagtgaggct gagctccaag tggcacaaca ggagaaccat      840

cacttaaatt tggacctgaa ggaggcgaag agctggcaag aggagcagag tgctcaggct      900

cagcgactga aagacaaggt ggcccagatg aaggacaccc taggccaggc ccagcagcgg      960

gtgaggccga gctggagccc ttgaaggagc agcttcgagg ggcccaggag cttgcagcct     1020

caagccagca gaaagccacc cttcttgggg aggagttggc cagtgcagca gcagccaggg     1080

accgcaccat agccgaacta caccgcagcc gcctggaagt ggctgaagtt aacggcaggc     1140

tggctgagct cggtttgcac ttgaaggaag aaaaatgcca atggagcaag gagcgggcag     1200

ggctgctgca gagtgtggag gcagagaagg acaagatcct gaagctgagt gcagagatac     1260

ttcgattg                                                              1268


<210> 3600
<211> 1036
<212> DNA
<213> Homo sapiens

<400> 3600
atgaagaaac cgaggcccgc ggctgccgcg ccctctcccc gccctccagc ctgctcgcgg       60

ggcgcccatc ctgggaccgc atccgagctc cgggttcccg ctctaagacg gggaggctgc      120

ggcgaccgca ggctcaggga ggaagccgct cctgaacagg cggctgcggg gccgcgcaga      180

tccaccgtgg gcgccctgct ggcatctgag ctgggatgga aattctatga tgctgatgat      240

tatcacccgg aggaaaatcg aaggaagatg ggaaaaggca taccgctcaa tgaccaggac      300

cggattccat ggctctgtaa cttgcatgac attttactaa gagatgtagc ctcgggacag      360

cgtgtggttc tagcctgttc agccctgaag aaaacgtaca gagacatatt aacacaagga      420

aaagatggtg tagctctgaa gtgtgaggag tcgggaaagg aagcaaagca ggctgagatg      480

cagctcctgg tggtccatct gagcgggtcg tttgaggtca tctctggacg cttactcaaa      540

agagagggac attttatgcc ccctgaatta ttgcagtccc agtttgagac tctggagccc      600

ccagcagctc cagaaaactt tatccaaata agtgtggaca aaaatgtttc agagataatt      660

gctacaatta tggaaaccct aaaaatgaaa tgacaatgat tttgtatcag tggtccaaac      720

agaactaagc ataaatcatt gtgccatccc aaacctcgtt ccagccgcct tgcccatact      780

agattctaaa tgtttctaaa ggcaaacccc aatgtgtcaa gacagacttg tttaggtgta      840

attttaggaa ttatgctggt tcatcaggaa gcagaggggg agttttaaaa gtcaagctta      900

aattgaagtt taaattcatc tataaccaaa tcaaatgatc agaggaaatt ctgtaatcaa      960

tgctggaaat cgttacattg tttagaacat tcttgctcat gcctgtattt gcacaaataa     1020

atgaaacttc gctgtc                                                     1036


<210> 3601
<211> 1910
<212> DNA
<213> Homo sapiens

<400> 3601
ataaccatga acttccatat ctgtcatagg aaagaggttg gcctcagcag caatgaggga       60

taattctttc aagaaaggaa tgaagagaga agttagatgg aaaagagatt tttaaggtca      120

aaagaagcag ctgaagaaca tgtgtaggac agccttagga gttactacac ttcaagacct      180

gggtgtctgc tggaggaagg aacatgaccc tgcggagatg ttaagggttg ggagagctga      240

gcttggaggc tggaagccca gctgggaggc tattgttaaa gaggttgctg cagcaactgg      300

tcacacagta gtgttggtag accagacaga ggacatcctg gcaaaatcca aaaagggaat      360

tgaggaaagc cttaggaaag tggcaaagaa gaagtttgca gaaaacctta aggccggcga      420

tgaatttgtg gagaagaccc tgagcaccat agcgaccagc acggatgcag cctccgttgt      480

ccacagcaca gacttggtgg tggaagccat cgtggagaat ctgaaggtga aaaacgagct      540

cttcaaaagg ctggacaagt ttgctgctga acatacaatc tttgccagca acacttcctc      600

cttgcagatt acaagcatag ctaatgccac caccagacaa gaccgattcg ctggcctcca      660

tttcttcaac ccagtgcctg tcatgaaact tgtggaggtc attaaaacac caatgaccag      720

ccagaagaca tttgaatctt tggtagactt tagcaaagcc ctaggaaagc atcctgtttc      780

ttgcaaggac actcctgggt ttattgtgaa ccgcctcctg gttccatacc tcatggaagc      840

aatcaggctg tatgaacgag gtgacgcatc caaagaagac attgacactg ctatgaaatt      900

aggagccggt taccccatgg gcccatttga gcttctagat tatgtcggac tggatactac      960

gaagttcatc gtggatgggt ggcatgaaat ggatgcagag aacccattac atcagcccag     1020

cccatcctta aataagctgg tagcagagaa caagttcggc aagaagactg gagaaggatt     1080

ttacaaatac aagtgatgtg cagcttctcc ggctctgaga agaacacctg agagcgcttt     1140

ccagccagtg ccccgagtgc ctgtgggaat gctctttggt cagacattcc ctcacacagt     1200

acagtttaat aaatgtgcat tttgattgta atctatcgaa gtgattatta caccagttac     1260

agcagtaata gattctccat taagaaataa ttcccttttt tagtctgttc atttctgtgt     1320

attttctaaa cagctttaca cccttggtgc cttggagcaa acatgttttt tgaaccttgt     1380

catttttgtg aagaattgcc tagattcctt ctctcatcaa cgggaaagta cttcctctga     1440

gagtgcgagt gcaccatgct cactgttgct gcgtgggaga gtcacaagcc actggcaagc     1500

aagtggtata gtctgtgaag cactgcagcg agcagcacct ggatcttgcc tttataagaa     1560

cattttacta cctgcagctt tgagtcttgc cctacatttt gggcatgaca taagatgtgt     1620

ctttattcag ctcgtcgtga agatgctgct gctgaatggg tcagcatatc tctgtttgca     1680

tggtttgcag gaggtcggtt ttcatggtca ttcagttcca cagatctgaa tgattactgt     1740

ctgtctgtgt cttttttcca tgagaaatca ctgttgcaaa ttgcctataa attgactcta     1800

ctaaaataac aatgtttcag tctgaaaatt tgaattgaaa aaaatgtata atataaaatt     1860

gtaatacact caaatgatta taaaagtaaa agttggtaat ttaggcagaa                1910


<210> 3602
<211> 804
<212> DNA
<213> Homo sapiens

<400> 3602
cggggccggg gccggggccg gagccggagc cggggccggg cggcgcgcct gtggagcgct       60

gggggcggcc tggggctgag catggagcag cgcggcggag gtcgcctgcg aggccgctgg      120

ccaggcctga gcctctgcca ccatggccat tgtgcagact ctgccagtgc cactggagcc      180

tgctcctgaa gctgccactg ccccacaagc tccagtcatg ggtagtgtga gcagccttat      240

ctcaggccgg ccctgtcccg gggggccagc tcctccccgc caccacggcc ctcctgggcc      300

caccttcttc cgccagcagg atggcctgct acggggtggc tatgaggcac aggagccgct      360

gtgcccagct gtgcccccta ggaaggctgt ccctgtcacc agcttcacct acatcaatga      420

ggacttccgg acagagtcac cccccagccc aagcagtgat gttgaggatg cccgagagca      480

gcgggcacac aatgcccacc tccgcggccc accaccaaag ctcatccctg tctctggaaa      540

gctggagaag aacatggaga agatcctgat ccgcccaaca gccttcaagc cagtgctgcc      600

caaacctcga ggggctccgt ccctgcctag cttcatgggt cctcgggcca ccgggctgtc      660

tgggagccag ggcagcctga cgcagctgtt tgggggccct gcctcctcct cctcctcttc      720

ctcctcctct tcagctgctg acaaacccct ggcatttagt ggctgggcca gtggctgccc      780

atcagggacg ctatccgact ctgg                                             804


<210> 3603
<211> 1280
<212> DNA
<213> Homo sapiens

<400> 3603
agtaactgac tacttttctc ccttctctag ggtcctagca cagtgtctga tggagctttc       60

ctaccagacc ctgaaattca cgcatcaggc gcgggaagcg gtatatcgat acagcaaatg      120

ctttggagca agaaactaaa ctggggttac gacggtttga agtttgtgac aacattgatc      180

ttgaaactat tttgatggaa tatgagagtt attattttgt aaaatttcag aaatacccca      240

aaattgtcaa aaagtcatca gacacagcag aaaataattt accgcaaaga agtagaggga      300

agaccagaag gatgatgaac gacagttgtc aaaatcttcc caagatcaat cagcagaggc      360

cccggtccaa aaccacagcg gggaagacag gggacaccaa atcgctcaat aaggagcatc      420

ctaatcagga ggtagttgat aacactcgcc tggaaagtgc caacttcggc ctacatatat      480

caagaatccg taaagacagt ggagaggaaa atgcccaccc acgaagaggc caaatcattg      540

acttccaagg gctgctcaca gatgccatca agggagcaac cagtgaactt gccttgaaca      600

ccttcgacca taatccagac ccctcagaac gactgctgaa acctctgagt gcatttattg      660

gcatgaacag tgagatgcga gaattggcag ccgtggtgag ccgggacatt tatctccata      720

atccaaacat aaagtggaat gacattattg gacttgatgc agccaagcag ttagtcaaag      780

aagctgttgt gtatcctata aggtatccac agctatttac aggaattctt tctccctgga      840

aaggactact gctgtacggc cctccaggta caggaaagac tttactggcc aaagctgtgg      900

ccactgaatg taaaacaacc ttctttaaca tttctgcatc caccattgtc agcaaatgga      960

gaggggattc agaaaaactc gttcgggtgt tatttgagct tgcccgctac cacgccccat     1020

ccacgatctt cctggacgag ctggagtcgg tgatgagtca gagaggcaca gcttctgggg     1080

gagaacatga aggaagcctg cggatgaaga cagagttact ggtgcagatg gatgggctgg     1140

cacgctcaga agatctcgta tttgtcttag cagcttctaa cctgccgtgc ttgaaagcca     1200

ttgcactcca gcctggcgac agagcaagac tccgtctcaa aaaaaaaaaa tgtactagtc     1260

cattttcatg ctgctggtga                                                 1280


<210> 3604
<211> 850
<212> DNA
<213> Homo sapiens

<400> 3604
gtccctcaag gccggaaaga aagtcgggct tctctagccc ctggaggact cgactcactg       60

gtgcgcgatt taggtccgga ggaggcgttg tgagagctgc ttggaaagag gaccaaagac      120

gtctaaaaag tcatttggaa atatctctaa atatttgtta ccatgtataa gctgctaaag      180

agaaattggg cccaacaaaa ctaattgaat aattgaggca gatttgtgtg tatcatcaaa      240

ttctatccag aagttgaaga atctgaattt aaagattgtg tgcatttaat aagaggatga      300

cctttcagtt taatttcact atagaagacc atctggaaaa tgaattaaca cccattagag      360

atggagcttt gaccctggat tcctcaaaag agctgtcagt ctcagaaagt caaaaaggag      420

aagagaggga cagaaaatgt tctgcagaac aatttgactt gcctcaggat cacttgtggg      480

aacataagtc aatggaaaat gcagctccct ctcaagacac agacagtcca ctcagtgcag      540

ccagcagttc aaggaacttg gagccacatg gaaaacagcc ctccttgaga gctgccaaag      600

agcatgctat gcctaaagat ttaaagaaga tgttagaaaa taaagtcata gaaacattac      660

caggtttcca gcatgttaag ttatcagtag tgaaaaccat cttgttgaaa gagaacttcc      720

ctggagaaaa catagtttca aaaagctttt cttctcactc tgatctgatt acaggtgttt      780

atgagggagg cttaaaaatc tgggaatgta cctttgacct cctggcttat ttcacaaagg      840

ccaaagtgaa                                                             850


<210> 3605
<211> 603
<212> DNA
<213> Homo sapiens

<400> 3605
tttgttgtga gctgcggcag agactggtgg ctggaggaga cgccggcgct ggagagtgcg       60

ctgcgccgcc cgccgctgag ggaccgcggg gttagccact gctggctgct tccagtgttc      120

gccgagaggt gtggaaatta aaagaacaca catattttga ctggggcttt gatcaaccaa      180

atgctaaaaa gccacataaa gaagatccct aatagtcatt tctcaacaat tatatagtca      240

actgatgtaa caatggtact aatattggga cgcagactaa acagagagga tcttggggtg      300

cgtgattccc cagcaactaa gcgaaaagtt tttgaaatgg accccaaatc tctgacaggt      360

catgagtttt ttgacttctc ttcaggatca tcccatgccg aaaacatact ccagatattt      420

aatgaatttc gtgatagccg cttattcaca gatgttatca tttgtgtgga aggaaaagaa      480

tttccttgcc atagagctgt gctctcagcc tgtagcagct acttcagagc tatgttttgt      540

aatgaccaca gggaaagccg agaaatgttg gttgagatca atggtatttt agctgaagct      600

atg                                                                    603


<210> 3606
<211> 1228
<212> DNA
<213> Homo sapiens

<400> 3606
gccctcatag ggcagaatgg gactcttgct gatgtagacg ccgaagtcgc gggcgctcat       60

ggcgggcctg gaggtactgt tcgcatcggc agcgccggcc atcacctgca ggcaggacgc      120

gctcgtctgc ttcttgcatt gggaagtggt gacacacggt tacttcggct tgggtgtcgg      180

tgaccagccg ggtcccaatg ataagaagtc agaactgctg ccagctgggt ggaacaacaa      240

taaagacctg tatgtcctcc ggtatgagta taaggatggg tccagaaagc tccttgtgaa      300

agccatcacc gtggagagca gcatgatcct caatgtgctg gaatatggct cacagcaagt      360

ggcagacttg accctgaact tggatgatta tatcgatgca gaacacctgg gtgacttcca      420

caggacctac aagaacagtg aggagcttcg gtctcgtatt gtgtctggaa tcatcacacc      480

tatccatgag cagtgggaaa aggctaatgt aagcagtccc caccgggagt tcccccctgc      540

taccgccaga gaggtggacc cactccggat tcctccacac cacccacaca ccagtcggca      600

gcctccctgg cctcggagag gtggcatgat tgtggatccc ctgagatctg gcttcccaag      660

agcacttatt gacccttcct caggcctccc gaaccgactt cctccaggcg ctgtgccccc      720

aggagctcgc tttgacccct ttggacccat tgggaccagc ccacccggac ctaacccaga      780

ccatctcccc ccgccgggct acgatgacat gtacctgtga aggcctcaag aatgtaacat      840

cccaggcttc cctccattct cctggagctg ccaccgctgt ccccatcagc aaccatgttc      900

ttgcaggctg ggggcaaggg attctgctca tgtgtttgca gaccggctgg gatagcctcc      960

ccacccctta tcagagccaa gacacctgct gcagctctcc acctagctgc agatagctcc     1020

caaagagaaa tcagtgtgtc tctttcacca tcagctcctc ccctttcacc accagctcct     1080

ctccacttcc caagggagac tccggcaacc ttcagcaaca tatatcctcg accagatgca     1140

gtgctataag aacagaacgc attttggatg ttattattaa gaaccaaatg tcaatacaga     1200

attcatgttg ccggtttccc acttttct                                        1228


<210> 3607
<211> 520
<212> DNA
<213> Homo sapiens

<400> 3607
gccctgacct tctctctgag agccggggcc gcttctgcgc aggatggaag gtgcccctgc       60

ggggccagga ggccggacag ccgcctgctt cagttgcaca tcacgatgcc tttctcgtcg      120

cccatggaag cggagctggt ccgcaggatc ctgtcccggg atgccgcacc tctcccccga      180

ccaggggcgg ttctgaagga cttcaccgtg tccggcaacc tactgtttat ccgactgact      240

gctgcagacc accgccaact gcagctctcc atcagctcct gtctccagca gctttccctg      300

ttgatgtgga tcacgcagtg ctttctgccc gtgtttttgg ctcaggctcc ctcagggcag      360

aggcgctaag cccagcctgg cgccccttcc taggtcatgc ctcctcccct agggaatggt      420

cccagcacga gtggccagtt cattgtgggg gcctgattgt ttgtcgctgg aggaggacgg      480

cttacatgtt tgtttctgta gaaaataaag ctgagctacg                            520


<210> 3608
<211> 2593
<212> DNA
<213> Homo sapiens

<400> 3608
gatgattttc agttttgaaa acgtggtgca tttcttttct gcttagttca aacctaaagg       60

caattgttta tttagaaatg aagtctattg gtgtaaagac tgtcaaggtt tgtgggtcaa      120

agagctctgt acgcatagaa ggtcagccat gttcattagg ccagagtaga aggaaagtca      180

agcttatggg tgaacggtcg tatactcttt caattggcaa cggagactac ttttgggcaa      240

ataaagaaat gctgtgggat tatgtgcaga ctctgtctga tcagggagca gagaaacatg      300

aaggcacagg tcagtcctct gggatcactg atcaagagaa ggagttatcc accaatgctt      360

tccaagcttt cacatctgga aattatgatg cctgtctaca acaccttgcc tgtctacaag      420

atataaacaa agatgattat aaaataattt tgaatacagc agtagctgag ttttttaaaa      480

gtaaccaaac aacaacagat aatttgagac aaacacttaa ccagctgaag aatcaggtcc      540

actcagctgt tgaagaaatg gatggattag atgatgttga aaacagcatg ttgtactata      600

atcaagcagt cattctttat catctgcggc agtatacaga agccatatca gttggtgaaa      660

aactttatca gttcatagag ccttttgaag aaaaatttgc ccaagcagtg tgttttttgc      720

ttgtagacct gtatatatta acctaccaag ctgagaaagc tttgcatctt cttgctgtcc      780

tagaaaaaat gatttcacag ggtaacaata acaaaaatgg aaagaatgag actggtaata      840

acaacaacaa agatggatct aatcataaag ctgaaagtgg agctctaata gaagctgcaa      900

aatcaaagat acatcagtac aaagtacgag cttatatcca aatgaagtct ctgaaagcat      960

gtaaaaggga aatcaagtca gtcatgaata cagctggaaa ttccgcaccc tctctctttc     1020

ttaaaagcaa ttttgagtac ttaagaggta attatcgaaa agccgtgaag ctattaaata     1080

gttcaaacat tgctgagcat ccaggattca tgaaaacagg tgaatgcttg agatgcatgt     1140

tctggaataa ccttggttgc atccattttg ccatgagcaa gcacaatttg ggaatattct     1200

actttaaaaa ggctctgcaa gagaatgaca atgtctgtgc acagctcagt gcaggtagca     1260

ctgatccagg taaaaaattt tcaggaagac ccatgtgtac gttactaacc aataagagat     1320

atgagttgct gtataactgt ggaattcagc ttcttcacat tggaaggcct cttgctgcct     1380

tcgaatgtct gattgaagct gttcaggttt atcatgcaaa tcctcgcctc tggctacggc     1440

tggctgaatg ctgcattgct gccaataagg ggacttctga acaagaaact aaaggccttc     1500

ccagcaaaaa aggaattgta cagtctattg ttggtcaagg ctatcatcgt aaaatagttt     1560

tggcatcaca gtctatacag aatactgttt ataatgatgg gcagtcttcg gccattcctg     1620

tagccagtat ggagtttgca gccatatgtc tcagaaatgc cttgttgctg ctacctgaag     1680

aacagcaaga tccaaagcag gaaaatgggg ctaaaaatag taatcaatta ggtgggaaca     1740

cagagagcag cgaaagcagt gaaacttgca gcagtaaaag ccatgatgga gataaattca     1800

ttccagctcc accttcttct ccattgagaa aacaggaatt agaaaactta aagtgctcca     1860

tacttgcttg cagtgcctac gtggctctgg ctttgggtga taacctcatg gctttgaatc     1920

atgcagataa acttcttcag cagcccaagc tgtcaggatc tcttaagttt ttgggacatt     1980

tatatgctgc agaagccctc atctctctcg acagaatatc tgatgccatt actcacttga     2040

acccggagaa tgtcactgat gtctccttag ggatctcttc aaatgagcag gaccaaggat     2100

cagacaaagg tgaaaatgaa gcaatggaat cctctggtaa gcgggcccct cagtgctacc     2160

ccagttccgt caactctgcc aggactgtga tgctgttcaa ccttggcagc gcttactgcc     2220

tgaggagcga atatgacaaa gcccgaaagt gtctccacca ggcggcttca atgatccatc     2280

ctaaagaggt gccccctgag gccatcttgc tggcagtcta ccttgaactg cagaatggta     2340

atactcagct ggccttacag atcatcaaaa ggaatcagct gctccctgca gtgaaaacac     2400

actctgaagt gagaaagaag ccagtgtttc agcctgtcca cccgatccag cccatccaaa     2460

tgccggcttt caccactgtg cagagaaagt gatacttcac ttttggaaaa ctgttacctg     2520

agacccaggg gagaatttac tggccatttt agttgtatca cagcagaatg aataaaagat     2580

ggtgaaggct gtt                                                        2593


<210> 3609
<211> 3080
<212> DNA
<213> Homo sapiens

<400> 3609
gaagtgagta gtgggggtgc cagaccaggt gcgtctgccg ctggattgtg ataggaagca       60

gagtgttcgt gtgaaagatg gatactatga tgctgaatgt gcggaatctg tttgagcagc      120

ttgtgcgccg ggtggagatt ctcagtgaag gaaatgaagt ccaatttatc cagttggcga      180

aggactttga ggatttccgt aaaaagtggc agaggactga ccatgagctg gggaaataca      240

aggatctttt gatgaaagca gagactgagc gaagtgctct ggatgttaag ctgaagcatg      300

cacgtaatca ggtggatgta gagatcaaac ggagacagag agctgaggct gactgcgaaa      360

agctggaacg acagattcag ctgattcgag agatgctcat gtgtgacaca tctggcagca      420

ttcaactaag cgaggagcaa aaatcagctc tggcttttct caacagaggc caaccatcca      480

gcagcaatgc tgggaacaaa agactatcaa ccattgatga atctggttcc attttatcag      540

atatcagctt tgacaagact gatgaatcac tggattggga ctcttctttg gtgaagactt      600

tcaaactgaa gaagagagaa aagaggcgct ctactagccg acagtttgtt gatggtcccc      660

ctggacctgt aaagaaaact cgttccattg gctctgcagt agaccagggg aatgaatcca      720

tagttgcaaa aactacagtg actgttccca atgatggcgg gcccatcgaa gctgtgtcca      780

ctattgagac tgtgccatat tggaccagga gccgaaggaa aacaggtact ttacaacctt      840

ggaacagtga ctccaccctg aacagcaggc agctggagcc aagaactgag acagacagtg      900

tgggcacgcc acagagtaat ggagggatgc gcctgcatga ctttgtttct aagacggtta      960

ttaaacctga atcctgtgtt ccatgtggaa agcggataaa atttggcaaa ttatctctga     1020

agtgtcgaga ctgtcgtgtg gtctctcatc cagaatgtcg ggaccgctgt ccccttccct     1080

gcattcctac cctgatagga acacctgtca agattggaga gggaatgctg gcagactttg     1140

tgtcccagac ttctccaatg atcccctcca ttgttgtgca ttgtgtaaat gagattgagc     1200

aaagaggtct gactgagaca ggcctgtata ggatctctgg ctgtgaccgc acagtaaaag     1260

agctgaaaga gaaattcctc agagtgaaaa ctgtacccct cctcagcaaa gtggatgata     1320

tccatgctat ctgtagcctt ctaaaagact ttcttcgaaa cctcaaagaa cctcttctga     1380

cctttcgcct taacagagcc tttatggaag cagcagaaat cacagatgaa gacaacagca     1440

tagctgccat gtaccaagct gttggtgaac tgccccaggc caacagggac acattagctt     1500

tcctcatgat tcacttgcag agagtggctc agagtccaca tactaaaatg gatgttgcca     1560

atctggctaa agtctttggc cctacaatag tggcccatgc tgtgcccaat ccagacccag     1620

tgacaatgtt acaggacatc aagcgtcaac ccaaggtggt tgagcgcctg ctttccttgc     1680

ctctggagta ttggagtcag ttcatgatgg tggagcaaga gaacattgac cccctacatg     1740

tcattgaaaa ctcaaatgcc ttttcaacac cacagacacc agatattaaa gtgagtttac     1800

tgggacctgt gaccactcct gaacatcagc ttctcaagac tccttcatct agttccctgt     1860

cacagagagt ccgttccacc ctcaccaaga acactcctag atttgggagc aaaagcaagt     1920

ctgccactaa cctaggacga caaggcaact tttttgcttc tccaatgctc aagtgaagtc     1980

acatctgcct gttacttccc agcattgact gactataaga aaggacacat ctgtactctg     2040

ctctgcagcc tcctgtactc attactactt ttagcattct ccaggctttt actcaagttt     2100

aattgtgcat gagggtttta ttaaaactat atatatctcc ccttccttct cctcaagtca     2160

cataatatca gcactttgtg ctggtcattg ttgggagctt ttagatgaga catctttcca     2220

ggggtagaag ggttagtatg gaattggttg tgattctttt tggggaaggg ggttattgtt     2280

cctttggctt aaagccaaat gctgctcata gaatgatctt tctctagttt catttagaac     2340

tgatttccgt gagacaatga cagaaaccct acctatctga taagattagc ttgtctcagg     2400

gtgggaagtg ggagggcagg gcaaagaaag gattagacca gaggatttag gatgcctcct     2460

tctaagaacc agaagttctc attccccatt atgaactgag ctataatatg gagctttcat     2520

aaaaatggga tgcattgagg acagaactag tgatgggagt atgcgtagct ttgatttgga     2580

tgattaggtc tttaatagtg ttgagtggca caaccttgta aatgtgaaag tacaactcgt     2640

atttatctct gatgtgctgc tggctgaact ttgggttcat ttggggtcaa agccagtttt     2700

tcttttaaaa ttgaattcat tctgatgctt ggcccccata cccccaacct tgtccagtgg     2760

agcccaactt ctaaaggtca atatatcatc ctttggcatc ccaactaaca ataaagagta     2820

ggctataagg gaagattgtc aatattttgt ggtaagaaaa gctacagtca ttttttcttt     2880

gcactttgga tgctgaaatt tttcccatgg aacatagcca catctagata gatgtgagct     2940

ttttcttctg ttaaaattat tcttaatgtc tgtaaaaacg attttcttct gtagaatgtt     3000

tgacttcgta ttgaccctta tctgtaaaac acctatttgg gataatattt ggaaaaaaag     3060

taaatagctt tttcaaaatg                                                 3080


<210> 3610
<211> 810
<212> DNA
<213> Homo sapiens

<400> 3610
gcgtgagggc ctgcgctgga gccggcttga cagggtctga gggggagtgg agaactgggc       60

gaggaggttc ccgtggtcgg cttacccgct ggccgcctcc tgacaagcgg gagggatccg      120

cggtggaccc agggaagcgg aggagcctgg cggccacccc ctcttcctca cttccctgta      180

ctctcatcgc tctcggcctc cgacacgaaa aggaagcaaa tgagctgatg gaagatctgt      240

ttgaaacttt ccaagatgag atgggattct ccaacatgga agatgatggc ccagaagagg      300

aggagcgtgt ggctgagcct caagctaact ttaacacccc tcaagctcta cggtttgagg      360

aactactggc caacctacta aatgaacaac atcagatagc gaaggaacta tttgaacagc      420

tgaagatgaa gaaaccttca gccaaacagc agaaggaggt agagaaggtt aaaccccagt      480

gtaaggaagt tcatcagacc ctgattctgg acccagcaca aaggaagaga ctccagcagc      540

agatgcagca gcatgttcag ctcttgacac aaatccacct tcttgccacc tgcaacccca      600

atctcaatcc ggaggccagt agcaccagga tatgtcttaa agagctggga acctttgctc      660

aaagctccat cgcccttcac catcagtaca accccaagtt tcagaccctg ttccaaccct      720

gtaacttgat gggagctatg cagctgattg aagacttcag cacacatgtc agcattgact      780

gcagccctca taaaactgtc aagaagactg                                       810


<210> 3611
<211> 3848
<212> DNA
<213> Homo sapiens

<400> 3611
gttgtgagct gcggcagaga ctggtggctg gaggagacgc cggcgctgga gagtgcgctg       60

cgccgcccgc cgctgaggga ccgcggggtt agccactgct ggctgcttcc agtgttcgcc      120

gagaggtacc gggggtgaca gctccgggac cggccgaaag gcgaggaacc ggaagcccgg      180

gggagtgcga ccgcctcaaa tccagccttc ttgtttggtg ggacgaccgt cggttctgtc      240

cgggaggaat gacggggtca aggtgtggaa attaaaagaa cacacatatt ttgactgggg      300

ctttgatcaa ccaaatgcta aaaagccaca taaagaagat ccctaatagt catttctcaa      360

caattatata gtcaactgat gtaacaatgg tactaatatt gggacgcaga ctaaacagag      420

aggatcttgg ggtgcgtgat tccccagcaa ctaagcgaaa agtttttgaa atggacccca      480

aatctctgac aggtcatgag ttttttgact tctcttcagg atcatcccat gccgaaaaca      540

tactccagat atttaatgaa tttcgtgata gccgcttatt cacagatgtt atcatttgtg      600

tggaaggaaa agaatttcct tgccatagag ctgtgctctc agcctgtagc agctacttca      660

gagctatgtt ttgtaatgac cacagggaaa gccgagaaat gttggttgag atcaatggta      720

ttttagctga agctatggaa tgttttttgc agtatgttta tactggaaag gtgaagatca      780

ctacagagaa tgtacagtat ctctttgaga catcaagcct ctttcagatt agtgttctcc      840

gtgatgcatg tgccaagttc ttggaggagc aacttgatcc ttgtaattgc ttaggaatcc      900

agcgctttgc tgatacccat tcactcaaaa cactcttcac aaaatgcaaa aattttgcgt      960

tacagacttt tgaggatgta tcccagcacg aagaatttct tgagcttgac aaagatgaac     1020

ttattgatta tatttgtagt gatgaacttg ttattggtaa agaggagatg gtttttgaag     1080

ccgtcatgcg ttgggtctat cgtgccgttg atctgagaag accactgtta cacgagctcc     1140

tgacacatgt gagactccct ctgttgcatc ccaactactt tgttcaaaca gttgaagtgg     1200

accaattgat ccagaattct cctgagtgtt atcagttgtt gcatgaagca agacggtacc     1260

acatacttgg gaatgaaatg atgtccccaa ggactaggcc acgcaggtcc actggctatt     1320

ctgaggtgat agttgtcgtt ggaggatgtg agcgagttgg aggatttaat cttccataca     1380

ctgagtgcta cgatcctgta acaggagaat ggaagtcttt ggctaagctt ccagaattta     1440

ccaaatcaga gtatgcagtc tgtgctctaa ggaatgacat tcttgtttca ggtggaagaa     1500

tcaacagccg tgatgtctgg atttataact cacagttaaa tatttggatc agagttgcct     1560

ctctcaataa aggcagatgg cgtcacaaaa tggctgtcct ccttggtaaa gtatatgttg     1620

tcggtggcta tgatgggcaa aacagactta gcagcgtaga atgttatgat tccttttcaa     1680

atcgatggac tgaagttgct ccccttaagg aagccgtgag ttctcctgca gtgactagct     1740

gtgtaggcaa actgtttgtg attggtggag gacctgatga taatacttgt tctgataagg     1800

ttcaatctta tgatccagaa accaattctt ggctacttcg tgcagctatc ccaattgcca     1860

aaaggtgtat aacagctgta tccctaaaca acctgatcta tgttgccggt ggactgacca     1920

aggcaatata ctgttacgat ccagttgaag attactggat gcacgtacag aatacattca     1980

gccgtcagga aaactgtggt atgtctgtgt gtaatggtaa aatatatatc ctgggcggaa     2040

gacgggaaaa tggagaagcc acagacacta ttctctgtta tgatcctgca acaagtatca     2100

tcacaggggt agctgcaatg cccaggccag tgtcctatca tggctgtgtg actattcata     2160

gatacaatga gaaatgcttt aaactctgaa gacaggatac ctcaccgaag aagccacact     2220

gatccaagat gggaggtttt aaaaactcta cagtgggaac ttcacatatc tcctttgtgc     2280

catatgcaaa aaatagtaaa aataataatt tggtgccttt ctcctcaaaa tatcaatctt     2340

tcaaactata ataaagcctt tcctataatt gaaaaaaaaa acttttttgt taaaggtaat     2400

ggtggttgtt acttggcctt tgaagagtgt acctttgtaa gtatttgtaa gaagtctatg     2460

tgaattagga aatgtctgtc tgcatacctt ttaggagcgt gtgaatggtg tcttcactta     2520

ttatgtatgt ttatctgtat gtatattcct tattttgtca tatatgtaga gaaaattgca     2580

tgacttgagg catcatttag gttgaagaag ttaatgctta ggatgcattc taggagaaaa     2640

aatcagtttt aaaaaccttt gttgttaaca aagtatatcc agattggtta attttattga     2700

agggtttttt tctgtaattg ataaaaatgt aatgacaaca attcaggcat cataaaatac     2760

tgaactattg tgactttatt cttagaattg ctgtcttaca ttaaacatgt ttttaggggg     2820

aagttaggta ggagatagaa aaataagtgc ccctacaagg gggattaaaa ttacaagtta     2880

attcctaaga gaaaaatgga atggcctttg aaggaaaaat gacccactat ggctctcaaa     2940

gtttttatgc atcatctctt caatcctcta agaaagcctc ttttcttaac ttgataaagc     3000

agtggaaacc cattttgcaa tattgttttg tgaaaaacag ggacagacag ccaggtacag     3060

agactcacac ctgtactccc aactactcag caggctgggg caggaggatt gcttgagccc     3120

aggagtctga ggctacagtg agctatgaac gcacacggca ccctagcctg ggcaacaggt     3180

tgcgacactg tctcaagaga aaagaaaaag aaaaataggg ataggttttc cttcctagcc     3240

cagtagagtt tgacctcatt agtatggtgc tttgggtgag gacctcttcc ttgattatcc     3300

cactttctag tgaacagcta aaattcctga gagtctctac tgttaaggta cctttaatag     3360

gataaagcag ggaccaccta tctcagtggg tccatttttc ttttaaaatt agttatctga     3420

aaaaacttag cagtagttcc catctttaag gtaagtcttt catttggtcc ccattgtgta     3480

aaatactaat caacattttc aagcttctgt acaacagact gcttttgtct agatttctca     3540

actccacttt ataaagctta tcagttttca gagaggaatg tgaatttttt ttctaatgca     3600

aataaatgga tatggcagga actacagcat aagtgattat tgtgattctg ggtggacgga     3660

tataatttac aacatttagg gatgttctag gtagcctgct gtagtttgac ttccagtcac     3720

tgttgtcttt cacattataa tttgtatatt tcttgtgata gaagggatga tgcaaatatg     3780

taattaaagt gtcaccagat ttctgttaaa accaaggttg aaataaaaag cctaacattg     3840

gtaagcta                                                              3848


<210> 3612
<211> 3478
<212> DNA
<213> Homo sapiens

<400> 3612
aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cggttgcttc      180

attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt      240

gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc tgtcgattga      300

ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt actgtgcttg      360

ctcctgactc tatgtcgcgt ctccaaggag aagaagtcct caccagtgaa cggagacctc      420

tctgaactaa ggataccatg gccacgtcag ccccactacg gagcctggaa gaggaggtga      480

cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt ggccacgtct      540

tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc gtctgcccac      600

tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg gccagcctgg      660

tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag gtgacccggg      720

agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac tactgtgagg      780

acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg      840

ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac cacctgagta      900

ccctaaggag ggacagagac aaaattcagg gcttccaggc aaagggagaa gctgatatcc      960

tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag tttgagcagg     1020

gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg aagctggagc     1080

aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag cttgcccggc     1140

tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca gagctcatgc     1200

aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt gggaaaccca     1260

ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc tctctgcaac     1320

gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag acagtgagcg     1380

tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac tggaagtgcg     1440

tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt gactgtgagc     1500

ctggggtgct aggcagcaag ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg     1560

agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag ggagaagagg     1620

aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa acggacgaag     1680

atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag gaagttctgg     1740

aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac ctctccctgc     1800

ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg gccaacacca     1860

gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc gccctggatt     1920

atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc tacaccttca     1980

ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca ggaacacgcc     2040

tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag atgcttcact     2100

tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag cacctggagc     2160

aggggacccc atatccactg gtagccacct ccccattgct gtggccccct gaaatctcac     2220

tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc ctgctggttt     2280

cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg accacgacct     2340

tggccccagc tctgcactct ctggaataag ggcccgatgc agcattttct tgcccagtgt     2400

ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt ccttaaaccc     2460

cccaggttcc ttcttgcaca aatccactct gctgcccacc ttccctggca ttttaaacag     2520

acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat aaacaaaatc     2580

cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat ctcatggggt     2640

ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat agccaaggag     2700

gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac acggctttgg     2760

ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg tgaggggagt     2820

tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca agacaaacat     2880

ccagtggagc agaacctctc ctgcctcggg agttctgacc gggttcccca gcagggtgtt     2940

aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag agagtggaga     3000

tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa     3060

gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca ggtgcccctc     3120

atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc agtcttgtcc     3180

ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc ctccaccctg     3240

ttctaagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac cattgtctca     3300

gagctgccca ctttgtgtgt gtcacatgct gcctgagtca catgtacatc ttatttctgc     3360

ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt gtattctcat     3420

ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt tgaatgaa       3478


<210> 3613
<211> 923
<212> DNA
<213> Homo sapiens

<400> 3613
cttatgtcaa tgctgttgat tcaaggtgga gttcatatgg caacgaggcc acatcatcag       60

cacactatgt tgaaagggac agattcattg ttactgattt atctggtcat agaaagcatt      120

ccagtactgg ggaccttttg agccttgaac ttcagcaggc caagagcaac tcattacttc      180

ttcagagaga ggccaatgct ttggccatgc aacagaagtg gaattccctg gatgaaggcc      240

gtcaccttac cttaaacctt ttaagcaagg aaattgaact aagaaatgga gagttacaga      300

gtgattatac agaagatgca acagatacta aacctgatag ggatatcgag ttagagcttt      360

cagcacttga tactgatgaa cctgatggac aaagtgaacc aattgaagag atcttggaca      420

tacagcttgg tatcagttct caaaatgatc agttgctaaa tggaatggca gtggaaaatg      480

ggcatccagt acagcagcac caaaaggagc caccaaagca gaagaaacag agtttaggga      540

ggagcaaaaa acaattctgc cggtaacttc ttgctttagc cagccactcc cagtgtctat      600

tagcaatgca agttgcctcc ccatcaccac atctgtcagt gctggcaacc tcattctgaa      660

aactcatgtt atgtctgaag ataaaaacga ctttttaaaa cctgttgcaa atgggaagat      720

ggttaacagc tgaaaggagg ttcatctttc aaatttgtga ccacaccatg gaagcattta      780

cactagcttt ttatatatat aatatatatt atataatgta tatttttttt aaaaaaaaga      840

tattactggg ggcatccatt tcctgtggac tctttgatac ttcaagccct cttgcattag      900

cattatgaaa aaaaaaaaga aaa                                              923


<210> 3614
<211> 2107
<212> DNA
<213> Homo sapiens

<400> 3614
aaaatgctcc cgccgacgca cagcagtgac gacacacaag gtttcgggga ctgagtgggt       60

ttcagacttt ctctcaggat ttccgctggc ttcaggttcc ggtcaggcgt cgggacagag      120

cctgatccag gcttcggcgg ccggtggcag ctctcgatca gctctcgcag tcggagaggc      180

ggctaaggaa aggtgccaca gcagagacgc gaaggagagg ccctagaacc ttttcaaaga      240

agaatggaag aaaccatgaa gcttgctacg atggaagaca cagtggagta ctgcctgttc      300

ctgataccag atgagtcaag ggactcagat aaacataaag agattcttca gaagtacatt      360

gagagaataa tcactcggtt tgcacctatg ctggtcccct acatctggca gaatcagcct      420

ttcaatctta aatataaacc tgggaaagga ggtgttcctg ctcatatgtt tggcgtgaca      480

aagtttgggg ataacattga ggatgaatgg tttattgttt atgtaataaa gcagatcaca      540

aaggaatttc cagagttagt agcaaggatt gaagacaatg atggtgaatt cttgttaata      600

gaagctgctg actttctccc taaatggctg gatcctgaaa atagcaccaa tagggtattt      660

ttctgccatg gggaattgtg tattatccct gcaccaagaa aatctggagc agaatcttgg      720

ttacccacca cacccccaac aattccacaa gcattgaata taatcacagc acattcagaa      780

aaaatacttg cttcagaatc tatacgagct gctgtgaata ggcgcatcag agggtaccca      840

gaaaaaattc aggcctcact tcatcgagca cactgcttcc ttccagctgg cattgtggca      900

gtgctaaagc agcgccccag attggtggct gcagcagtcc aggcatttta cctacgagac      960

cctattgacc tgcgagcttg tcgtgttttc aagacattct tgcctgaaac acgaataatg     1020

acatcggctc atggatttga gatcttatgc tccaaatgta gcccacattt ttctgactgc     1080

aagaaatccc ttgtgactgc ctcaccactc tgggccagtt tccttgaaag tctgaaaaag     1140

aatgattact ttaagggact gatagaaggt tctgctcagt accgggaaag gctagaaatg     1200

gcagagaatt acttccagct ctcagtagac tggccagaaa gttctcttgc tatgagccct     1260

ggtgaagaaa tcttaacctt attacagaca ataccatttg atatagaaga ccttaagaaa     1320

gaagcagcta atcttccccc agaggatgat gaccagtggt tagatctctc accagatcag     1380

ctggaccagc tgctgcagga agctgttggc aaaaaagaat ccgagtctgt ttccaaggag     1440

gagaaggagc agaactatga cttaactgaa gtctcagaga gcatgaaagc tttcatatcc     1500

aaagtctcaa cccacaaggg agcagagctg cctcgagaac cttctgaggc tccaatcact     1560

tttgatgcag attcttttct taattatttt gataagattt tagggccaag gcctaatgag     1620

tcagattctg atgatctgga tgatgaagac tttgaatgtt tagatagtga tgatgacttg     1680

gactttgaaa cacacgaacc tggcgaagag gcttccctga aaggaacact tgataatctc     1740

aagtcataca tggcccagat ggaccaggaa ctagcacaca cctgcatcag caaaagtttc     1800

accactagga accaagtgga acctgtatcc cagactaccg ataacaattc agatgaggaa     1860

gattctggta cgggagaatc tgttatggca ccagtagatg tagacctgaa cctggtttca     1920

aatatattgg aatcctatag ctcccaagct ggactggcag gacctgcttc caatctttta     1980

caaagcatgg gagtgcagct gcctgacaac accgatcaca gaccaacaag taagccaaca     2040

aaaaattaac cagcacattt agcttctctt ttttcttttt aaataaatat tgaatatgat     2100

tctgttc                                                               2107


<210> 3615
<211> 2108
<212> DNA
<213> Homo sapiens

<400> 3615
ggggccgcac cgtaaatggg tgtcgccttt cctccagtcc actctgcacc caacctcagc       60

gggcgcactt ttctgagttg cgcataccct ctcaattatt aaaggttgca gacggaaaag      120

ttagtagttt tcggaattgt agaatacgct cgtgcagcgc caggacggct aatgcttacc      180

cgaaaatgtg gaaccctgat ctccccatgc gtggagcgag gttggaggta gcgtagtaag      240

aatactggag ttgcttaaac gcatttgctc gaaagtcact accctggata tacattctgg      300

ccaaaagaaa gggggaaaaa ctccacattt ttctcaaata ctgagtttca tgaagagaac      360

ctccaacaaa tggtatataa aggaaaacaa agcaaacaaa agagggaaac tttgcaattt      420

attaactcaa gcatgaaaat acagaaaata aagagggctc aacatacttg gaaaaggaaa      480

aaacatgaag aaaaaacatg atggcattgt ttatgaaact aaagaagttc tcaatccatc      540

tcccaaagta acacattgtt gcaaatcact gtggttaaaa tacagttttc agaaggcata      600

catgacccaa cttgtcagct cccagccagt tccagccatg tcaaggaacc cagatcataa      660

tctactttct cagcccaagg agcatagcat tgttcagaag catcaccagg aggaaataat      720

tcacaagttg gccatgcagc tgagacacat tggggacaac attgatcata ggatggttcg      780

agaggatctt caacaggatg gcagagatgc actagatcat tttgtcttct ttttctttag      840

aagagttcag gtgttgctgc attttttctg gaacaaccat ttgctgtaaa aggaaagtaa      900

aggtcaagtg gtcaagttct gttttctttt taccctctga gaaacatgaa tcccactggg      960

acagatggga agaacaccct tctccgtctc cctctttttg tacccatcac tgttggtcta     1020

cacccagttt gttgaagaac tgcgggttca cgagccattt gtctcttcgg aggagctagc     1080

tatgagatgt ctgcgatcac atcacggtaa agcccaagga gtaattagga ccccaggaag     1140

ccttgctgcc cagaaaacac cagcgctgtg gatggtccca gggctccttg tgaggaaacc     1200

ttgaacattt ccttccagga atgaaagaga acctcgtcct caaactaaag gccacagaaa     1260

tgggcactac ctcctggccc actccctggg caccatgccc tctggtgacc tgttggctcc     1320

actcttgtca ctcatgtcca gatctgcagt gccagcttct ccttctcggt gacatgtcac     1380

ctccctgccc caatcctggc tccaaccctc tctggaaaat cgaagtgaaa catttgtctc     1440

taatactcaa attcaacata tggctcatct catctacctt cccatttcca tgcctagagg     1500

ccccactact accactagca ccgttgggtg tttccttctc aggctctgat tctacaacat     1560

ttacgttctt ttctcacctt tgatcccctc actcctctgt gacccccttc aagtcttcct     1620

tcaccactcc agtgttttcc cataccactc gaccctgctc gaaggtatct ttccctgctc     1680

tgtcatcctc ttttaggcat gcctgcttaa aatcgggagt gcttagtcct tggccaacag     1740

tcctgccttc tagaagaatg taagacctga aagagttatg aatctatcac taggcaaaaa     1800

cttctctttt cctattgctg gatggttttg ctattattgg ttggtgggcc ctttgcctgt     1860

ggaatgtatt tcactcattc tctcctgcac gctgttaggc agttctttca cctgcatgct     1920

tcttctttta cctttttgtc tacctcatag tccctctctc ccctccttta aaagaattat     1980

aaatattagg aaagcttgtt gttataaatt aaaagtttac atatgtatct tgagttcttc     2040

ataggggaag tgttatttta aaaaattcta aaaatgaaat aaatattgtt attttattga     2100

gcatgaaa                                                              2108


<210> 3616
<211> 2359
<212> DNA
<213> Homo sapiens

<400> 3616
gcgagtgggg aagctgctaa cccgacccgg attggcgctg aggtggcccg tggggcaggg       60

cagatgattc tggaccagat gaagcctgag gagccttcca gctctaagat agcaggatag      120

gagacttcta agattggagc tgcagaagac ttgccagccc accagcacaa tgtcagaagg      180

aagagtcagc agagcaacca gagttctact acgatgagtt tggtttccgt gtgtacaagg      240

aagaaggtga tgagcctggc tccagtctgc tggcgaactc ccctctgatg gaggatgctc      300

cacagaggct gcggtggcag gcccacctgg agttcaccca taaccacgat gtgggggatc      360

tcacctggga caagattgcc gtctccctac cccgctctga gaagctccgc tccctggtgc      420

tggccggcat cccacatggc atgaggccac agctgtggat gcggctctct ggggccctgc      480

agaagaagag gaactctgag ctgtcctacc gcgagattgt gaagaacagc tccaacgatg      540

agaccatcgc tgccaagcag atcgagaagg acctgctccg caccatgccc agcaacgcct      600

gcttcgccag catgggtagc atcggggtgc cccgcctgcg cagggtgctc cgggccctgg      660

cctggctcta cccagagatc ggctactgcc agggcaccgg catggtggcc gcctgcctcc      720

tgctgttcct ggaggaggag gacgccttct ggatgatgtc tgccatcatc gaggacctgc      780

tccccgcctc ctacttcagc accaccctgc tgggtgtcca gactgaccag cgggtcctgc      840

gccacctcat tgtccagtac ctgcctcgcc tggacaagct gctccaggag catgacattg      900

agctgtccct gatcacactg cactggttcc tcacggcctt cgccagcgtg gtggacatca      960

agctgctcct gcgcatctgg gacctgtttt tctacgaggg ctcccgggtg ctgttccagc     1020

tcacgctggg catgctgcac ctcaaggagg aagagctgat ccagtcagag aactcggcct     1080

ccatcttcaa cacgctatcg gatatcccgt cgcagatgga ggacgcggag ctgcttctgg     1140

gggtggccat gcggctggcc ggctccctca ccgatgtggc cgtggagact cagcgccgca     1200

agcacctggc ctatctcatt gcagaccagg gccagctcct gggggccggc accctcacca     1260

acctctctca ggttgttcgc cgcaggaccc agcggaggaa gtccaccatc actgctctgc     1320

tcttcgggga ggatgacctg gaggcactca aggccaagaa catcaagcag acggaactgg     1380

tggctgacct ccgggaagcc atcctgcgcg tggcacgcca cttccagtgc acagacccca     1440

aaaactgcag cgtggagctg actccagact atagcatgga gagccaccag cgggaccacg     1500

agaactacgt ggcgtgctca cgcagccacc ggcgccgagc caaggccctg ctggactttg     1560

agcggcacga cgacgacgag ctgggcttcc gcaagaacga catcatcaca atcgtgtctc     1620

agaaggacga gcactgctgg gtgggggagc tcaacggcct gcgaggctgg tttccagcca     1680

agttcgtgga agtcctggat gagcgcagca aagagtactc catcgcgggg gatgactcgg     1740

tgacggaggg ggtcacagac ctcgtgcgag ggaccctctg cccggccctt aaggccctgt     1800

tcgaacatgg actgaagaag ccatccctgc ttgggggcgc ctgccacccc tggctgttta     1860

tcgaggaggc tgcaggccgg gaggtcgaga gagactttgc ctccgtgtat tcccgtctgg     1920

tgctctgtaa gaccttcagg ttggatgaag atggcaaagt cctgaccccg gaggagctgc     1980

tctaccgggc tgtgcagtct gtgaacgtga cccacgatgc agtgcatgca caaatggatg     2040

tgaagctccg ctcactgatc tgcgtggggc tcaagtgagt gtggaaaagg ggttggagga     2100

gagccctgga gtggggggac ccagcccagc atcagggggg gtccttacag ggaaccctaa     2160

aggacaaaga acctcagggg ctcaggtcct tccccaaaga gggtggtctg ggagctgctg     2220

agagacaggt cagaggcttc caccgtggct gcagccagaa gggcctggag ctgcccctgc     2280

tccccactcc tggccatgtc cccagtgagc aggtgctgca cctgtggctg gaggtgctct     2340

gctccagcct gcccaccgt                                                  2359


<210> 3617
<211> 452
<212> DNA
<213> Homo sapiens

<400> 3617
ctggcagggg acgagctgcg gcggtggcac ctccgggtgt ggaaggctcc agtgagatgg       60

agtcgcgagt cgcggacgct gggaccggcg agaccgcgcg agcagcgggc gggagtccgg      120

cagttggctg caccactcgg gggcccgtag tctcggcgcc cctgggagcc gcccggtgga      180

agctcctgcg gcaggttctg aagcaaaaac acctggatga ttgcctgcga catgtatctg      240

taagaagatt tgaatcattt aatctgtttt cagtaacaga aggcaaagaa agggaaactg      300

aagaggaggt tggtgcatgg gtccaatata caagcatctt ctgtcctgaa tacagtatct      360

ccttaaggca taatagtgga tccttgaatg ttgaagatgt ccttaccagc tttgacaata      420

caggaaatgt gtggagtttt tctagaggaa aa                                    452


<210> 3618
<211> 3478
<212> DNA
<213> Homo sapiens

<400> 3618
aacagaccgc cgtgagagag gaggggcgcc ggccgggatt cgcggcccgg agctcgggac       60

cggagtcagg aatggagaga agggtaatgg tgttacctct tattgtggaa acctgttgag      120

atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg cggttgcttc      180

attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt      240

gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc tgtcgattga      300

ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt actgtgcttg      360

ctcctgactc tatgtcgcgt ctccaaggag aagaagtcct caccagtgaa cggagacctc      420

tctgaactaa gaataccatg gccacgtcag ccccactacg gagcctggaa gaggaggtga      480

cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt ggccacgtct      540

tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc gtctgcccac      600

tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg gccagcctgg      660

tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag gtgacccggg      720

agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac tactgtgagg      780

acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg      840

ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac cacctgagta      900

ccctaaggag agacagagac aaaattcagg gcttccaggc aaagggagaa gctgatatcc      960

tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag tttgagcagg     1020

gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg aagctggagc     1080

aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag cttgcccggc     1140

tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca gagctcatgc     1200

aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt gggaaaccca     1260

ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc tctctgcaac     1320

gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag acagtgagcg     1380

tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac tggaagtgcg     1440

tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt gactgtgagc     1500

ctggggtgct gggcagcaag ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg     1560

agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag ggagaagagg     1620

aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa acggacgaag     1680

atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag gaagttctgg     1740

aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac ctctccctgc     1800

ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg gccaacacca     1860

gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc gccctggatt     1920

atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc tacaccttca     1980

ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca ggaacacgcc     2040

tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag atgcttcact     2100

tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag cacctggagc     2160

aggggacccc atatccactg gtagccacct ccccattgct gtggccccct gaaatctcac     2220

tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc ctgctggttt     2280

cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg accacgacct     2340

tggccctagc tctgcactct ctggaataag ggcccgatgc agcattttct tgcccagtgt     2400

ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt ccttaaaccc     2460

cccaggttcc ttcttgcaca aatccactct gctgcccacc ttccctggca ttttaaacag     2520

acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat aaacaaaatc     2580

cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat ctcatggggt     2640

ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat agccaaggag     2700

gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac acggctttgg     2760

ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg tgaggggagt     2820

tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca agacaaacat     2880

ccagtggagc agaacctctc ctgcctcggg agttctgacc gggttcccca gcagggtgtt     2940

aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag agagtggaga     3000

tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa     3060

gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca ggtgcccctc     3120

atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc agtcttgtcc     3180

ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc ctccaccctg     3240

ttataagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac cattgtctca     3300

gagctgccca ctttgtgtgt gtcacatgct gcctgagtca catgtacatc ttatttctgc     3360

ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt gtattctcat     3420

ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt tgaatgaa       3478


<210> 3619
<211> 2952
<212> DNA
<213> Homo sapiens

<400> 3619
cgccaaggaa agatgggacc tcccggccca gtacttaaat tcacatagct gcagagtgga       60

tatttgtccc agattaacaa agaagcatca gaaacctatg gcctcccccc tgcacctcca      120

agaaacccaa actctagagg ttctagccat taagtattag agttggagaa gatctcagtg      180

gacagtgtgt ggtgaacctc cacccctgtg acaggctcaa gacttctttg gatataggaa      240

atgttctctt gaaggtttct tgagcaagaa ttttgttcca gcactgccag ccacaatgaa      300

taactcttct tcagagacgc gaggacaccc ccacagtgcc tcctctcctt cagagcgtgt      360

gttcccgatg cccctgccca ggaaggcgcc tctcaatatt cctggcaccc cagtcctcga      420

agactttcct cagaatgacg atgagaagga gcggctgcag cggaggcgct cgagggtctt      480

tgatctgcag ttcagcactg actcacctcg cttattggcc tccccctcca gcaggagtat      540

tgacatttca gctactatcc ccaagtttac aaacacgcag attacggaac attactccac      600

ctgtatcaaa ctgtccactg aaaataaaat cactaccaag aatgcttttg gtttgcactt      660

gattgatttt atgtcagaga ttcttaaaca gaaagacacc gaaccaacca actttaaagt      720

ggctgcgggt actctggatg ccagcaccaa gatctatgct gtgcgcgtgg atgccgtcca      780

tgccgatgta tacagagtcc ttggggggct gggcaaagat gcaccgtctt tggaagaagt      840

agaaggccat gttgctgatg gaagtgctac tgaaatggga acaaccaaaa aggctgtaaa      900

gccaaagaag aagcacttac acagaactat tgagcagaac ataaacaacc tcaatgtctc      960

cgaagcagat cggaagtgtg agattgatcc catgtttcag aagacagcag cctcatttga     1020

tgagtgcagc acagcagggg tgtttctgtc cactctccac tgccaggact acagaagtga     1080

actgctgttt ccctctgatg tccagactct ctccacggga gaacctctcg agttgccaga     1140

gttaggttgt gtagaaatga cagatttaaa agcgcccttg cagcagtgtg cagaagatcg     1200

ccagatctgc ccttccctgg ccgggttcca gtttacacag tgggacagtg aaacacataa     1260

tgagtctgtg tcggccctgg tagacaagtt taagaagaat gaccaggtat ttgacatcaa     1320

tgctgaagtt gacgagagtg actgtggaga cttccccgat gggtccctgg gggatgactt     1380

tgatgccaac gatgaacctg accacaccgc agttggggat catgaagagt tcaggagctg     1440

gaaggagccc tgccaggttc agagctgcca ggaagaaatg atttcccttg gggatggaga     1500

catcaggacc atgtgccccc ttctgtctat gaaacctgga gaatattctt atttcagtcc     1560

tcggaccatg tcgatgtggg ctggcccgga tcactggcgc tttaggcctc gacgcaaaca     1620

agatgctcct tcccaatcag aaaacaaaaa gaagagtaca aaaaaagatt ttgaaattga     1680

ctttgaagat gatattgact ttgatgtata ttttagaaaa acaaaggctg ctactattct     1740

gaccaagtcc actttggaga accagaattg gagagctacc acccttccta cagatttcaa     1800

ctacaatgtt gacactctgg tccagcttca cctcaaacca ggcaccaggt tacttaagat     1860

ggcccagggc catagggtag agactgagca ttatgaagaa attgaagact atgattacaa     1920

caaccctaac gacacctcca acttttgccc tggattacag gctgctgaca gtgatgatga     1980

agatttggat gacttatttg tgggacctgt tgggaactct gacctctcac cttatccttg     2040

ccatccacct aagacagcac aacagaatgg tgacactcca gaagcccaag gattagacat     2100

cacaacatat ggggagtcaa acttggtagc tgagcctcag aaggtaaata aaattgaaat     2160

tcactatgcc aagactgcca aaaagatgga catgaagaaa ctgaagcaga gcatgtggag     2220

tctgctgaca gcgctctccg gaaaggaggc agatgcagag gcaaaccaca gggaagctgg     2280

aaaagaagcg gccctggcag aagtggctga cgagaagatg cttagcgggc tcacgaagga     2340

cctgcagagg agcctgcccc ctgtcatggc tcagaacctc tccatacctc tggcttttgc     2400

ctgtctccta catttagcca atgaaaagaa tctaaaactg gaaggaacag aggacctctc     2460

tgatgttctt gtgaggcaag gagattgagt tcactatgga gaagtcagca gcaggaggcc     2520

catcccttac tcagttgccg ggacatcccc agtctcgggg gaagaagatg ccatgggctt     2580

atacccaggc tgtagccaac taccaacgtg cctgtttgtt tgttgctctt tccttctctc     2640

catcatagtc tgggtgccag cgccctgaag ctccgtgctc aactgattaa actttactgc     2700

cctatggtga ccatctagga gaggggaggg cagagggggt gagggtacta ttctggattg     2760

agaaaaccta tatccattct ttatatcaat gtatagtttt agtctcctaa attgatctgt     2820

tattttccaa actattctct tgtagaaaat tttccagtgg gcacttaatg gtgcccttga     2880

agaacttcct aatccatgta cataaaatac atcatatgta cacttataaa tgtatataga     2940

atgctcaaaa at                                                         2952


<210> 3620
<211> 1804
<212> DNA
<213> Homo sapiens

<400> 3620
atccgttaga aggagcattg aggagtagat acccacttgc catggcctgt gggccggggg       60

atcttcaaag ccttacatct ccgctttcct ctgccagatt agattatcag ccgtctattg      120

aagggccctg gctccgggcc tgcggtcaga ccaacgtgtc ctgcagggtg gtgaagggga      180

agctggtaga ggtaggcaag tggccatggc agagattcaa ggacctcagc ctgtactccg      240

tgatggtggg agtccaccag cgcccagaaa atagcactca gctcccgctc actcgcatgg      300

tgattcataa ggatttcagc aatctcatgt ctcaggacat tgccctccta aagctcaggg      360

actccatctc gtggtccccc ttcgtccagc ctgtctgcct ccctaacatc aaattcaagc      420

catccattgg aagcatgtgc tgggtaatcg gctggggaac tacagggaaa aaaggttgac      480

tctggaagct cccttgtctg ccaaatggac aagacctgga ttcagatagg agtggtaagc      540

tggagcttta gttgtggcca gcgccacttc ccagttcctt gggcaaagcc ccactggagg      600

ggctggaggg aaagtagggt cacttggaga tcctggatgc cagcccctga ggtttggtct      660

tcatctcact gcgggagggg tgacaccatg agccagtcca gggcaatggg ctgcgaggcc      720

ggcctcgcct tctctggcag accccgacca cccagacact gccctcgacc accatggaga      780

cccaattccc agtttctgaa ggcaaagtcg acccataccg ctcctgtggc ttttcctacg      840

agcaggaccc caccctcagg gacccagaag ccgtggctcg gcggtggccc tggatggtca      900

gcgtgcgggc caatggcaca cacatctgtg ccggcaccat cattgcctcc cagtgggtgc      960

tgactgtggc ccactgcctg atctggcgtg atgttatcta ctcagtgagg gtggggagtc     1020

cgtggattga ccagatgacg cagaccgcct ccgatgtccc ggtgctccag gtcatcatgc     1080

atagcaggta ccgggcccag cggttctggt cctgggtggg ccaggccaac gacatcggcc     1140

tcctcaagct caagcaggaa ctcaagtaca gcaattacgt gcggcccatc tgcctgcctg     1200

gcacggacta tgtgttgaag gaccattccc gctgcactgt gacgggctgg ggactttcca     1260

aggctgacgg catgtggcct cagttccgga ccattcagga gaaggaagtc atcatcctga     1320

acaacaaaga gtgtgacaat ttctaccaca acttcaccaa aatccccact ctggttcaga     1380

tcatcaagtc ccagatgatg tgtgcggagg acacccacag ggagaagttc tgctatgagc     1440

taactggaga gcccttggtc tgctccatgg agggcacgtg gtacctggtg ggattggtga     1500

gctggggtgc aggctgccag aagagcgagg ccccacccat ctacctacag gtctcctcct     1560

accaacactg gatctgggac tgcctcaacg ggcaggccct ggccctgcca gccccatcca     1620

ggaccctgct cctggcactc ccactgcccc tcagcctcct tgctgccctc tgactctgtg     1680

tgccctccct cacttgtggg ccccccttgc ctccgtgccc aggttgctgt gggtgcagct     1740

gtcacagccc tgagagtcag ggtggagatg aggtgctcaa ttaaacatta ctgttttcca     1800

tgcc                                                                  1804


<210> 3621
<211> 2903
<212> DNA
<213> Homo sapiens

<400> 3621
ggggtgtggc tctgccggcc caggcgcgat gaggcggctg cccgctgggt ggcgccgatt       60

tcccggggag gtcccttctg ggcccccggc ggaggtggga gagagtcagg caggagccga      120

ggccggggag ccctcttcgt cagctggtgc tcactgcgcc gcgccagcgc cagccgggac      180

tcacccgcag ctccatgctt gtgcccggtt cgactcgtcc atactccaag aagaggcaga      240

attctaagag tgcccagggt ctggctggtc ttcgaaacct tgggaacacg tgcttcatga      300

actcaattct gcagtgcctg agcaacactc gggagttgag agattactgc ctccagaggc      360

tctacatgcg ggacctgcac cacggcagca atgcacacac agccctcgtg gaagagtttg      420

caaaactaat tcagaccata tggacttcat cccccaatga tgtggtgagc ccatctgagt      480

tcaagaccca gatccagaga tacgcaccgc gctttgttgg ctataatcag caggatgctc      540

aggagttcct tcgctttctt ctggatgggc tccataacga ggtgaaccga gtgacactga      600

gacctaagtc caaccctgag aacctcgatc atcttcctga tgacgagaaa ggccgacaga      660

tgtggagaaa atatctagaa cgggaagaca gtaggatcgg ggatctcttt gttgggcagc      720

taaagagctc gctgacgtgt acagattgtg gttactgttc tacggtcttc gaccccttct      780

gggacctctc actgcccatt gctaagcgag gttatcctga ggtgacatta atggactgca      840

tgaggctctt caccaaagag gatgtgcttg atggagatga aaagccaaca tgctgtcgct      900

gccgaggcag aaaacggtgt ataaagaagt tctccatcca gaggttccca aagatcttgg      960

tgctccatct gaagcggttc tcagaatcca ggatccgaac cagcaagctc acaacatttg     1020

tgaacttccc cctaagagac ctggacttaa gagaatttgc ctcagaaaac accaaccatg     1080

ctgtttacaa cctgtacgct gtgtccaatc actccggaac caccatgggt ggccactata     1140

cagcctactg tcgcagtcca gggacaggag aatggcacac tttcaacgac tccagcgtca     1200

ctcccatgtc ctccagccaa gtgcgcacca gcgacgccta cctgctcttc tacgaactgg     1260

ccagcccgcc ctcccgaatg tagcgccagg agccacgtcc cttctccctt ccccgtggtg     1320

gccccgctcc ctaaattttt taaaaagaca aaaacaaaac aacaacaaca acacacaaac     1380

ctgacaagag aaaaacaaac ctgaagctgc cgagcaggag tggatgcagc ctgatcaggg     1440

tctggagcaa ggagccgggc tttcctgagc tgtggcccgg cagggaagat cgcctggacg     1500

tggagccagc atcgccccgt gccctcggcg tttgcatttg taaacttgtg gtcttcctat     1560

gtgtcagaaa caactgtgtc ttggggggga agaccctcgc tgcgccgctt cccgccgcag     1620

cgcccgcgcc tccgagggga cagcgccctc tggagctcgc tgggagcatc accgcctgga     1680

cgcccgcgcc gcggaggagc cggcgcccat ctccacccgc acggctcgcc ggtccagagc     1740

catgagccaa gagccctctt cacgctgcta actccagggg acagacgaag ggacatcttt     1800

ggaaaacgct ggttttggtt tttaaaaagc ccaacttttt ttttttaatt tccataacta     1860

aagtgttcag actggagtgc tctccttcag gcctcttcat agctgggacg ttgcactggt     1920

ccttttattg cttttccaag tacaactttc taatgctagc cctccgtggt gctaggtggg     1980

cgttggccag gccccaagca cagccacagt agacctggga tctaaaacaa gtttctgttt     2040

tgggggtttg ggtttttttt tttttttttt aatgttttga atggaattta gttgcctcca     2100

agaattgtgc cttatagcat ttggggacca gggggtaact gcccctcctg aaatatccct     2160

cagcctcttc ccttttcccc agtgctctgt tcaaacccgc ctgggaaagg gatcctgccc     2220

ttagccctgg ctcgttgtgc attgcagtga ggcaaagaag aaagcaggta gattccttcc     2280

gacagggcat caagttcttc ccgcccacgt cctctagccc acccctggtc tgctccccag     2340

ctgtttgaag gatagcacaa gcccctcgtc cctagagctt ctctcccttt tatttattct     2400

cttaacatcc ctttccccct ggccttcctg cccccgcccc cttctcagag cctcctagac     2460

aataggccct ttggaccgag tttctcaggg atgcccaggc cacccctcag ctcttcttag     2520

cgctggtctc cagtcctgcc ctgggagctg gagcctgggt atttggggac atcttgcctc     2580

agttgtatgg ttctttcctg tgggctcaat tttgccctac atagttggat aaaactctgt     2640

gctgtcctgg agagtaaagc tgttcaccca cacagctggg cccggcttgt gccccgtgga     2700

gcctggcaca ttccaggctc ctaggaggag gcatcagaga aagacaccct gagttttact     2760

ggcctgacac ccttctccag agaagacctg tgaacctgag cccaagggca agtgtacact     2820

tgtttactgt gtaagcaaga gtagaagaat gtctaatgta cagtggaacc ttgtacagaa     2880

taaataatag ctttgagaaa tca                                             2903


<210> 3622
<211> 3045
<212> DNA
<213> Homo sapiens

<400> 3622
gatggacccc ggcgacgccg ccattttgga gtcttcccta aggatcctct accggctttt       60

cgagtcagtg ctgccgccgc tgcccgcggc tttgcagagc aggatgaatg tgatagacca      120

cgtgcgggac atggcggccg cggggctgca ctccaacgtg cggctcctca gcagcttgtt      180

acttacaatg agtaataaca accctgagtt attctcccca cctcagaagt accagctttt      240

ggtgtatcat gcagattctc tctttcatga taaggaatat cggaatgctg tgagtaagta      300

taccatggct ttacagcaga agaaagcgct aagtaaaact tcaaaagtga gaccttcaac      360

tggaaattct gcatctactc cacaaagtca gtgtcttcca tctgaaattg aagtgaaata      420

caaaatggct gaatgttata caatgctaaa acaagataaa gatgccattg ctatacttga      480

tgggatccct tcaagacaaa gaactcccaa aataaacatg atgctggcaa acctgtacaa      540

gaaggctggt caggagcgcc cttcagtcac cagctataag gaggtgctga ggcagtgccc      600

attagccctt gatgccattc taggcttgtt gtccctttct gtaaaagggg cagaggtggc      660

atccatgaca atgaatgtga tccaaaccgt gcctaacttg gactggctct ctgtgtggat      720

caaagcgtat gcttttgtgc acactggtga caactcaaga gcaatcagta ccatctgttc      780

actagagaaa aaatccttat tgcgagataa cgtggaccta ttgggaagct tggcagatct      840

gtacttcaga gctggagaca ataaaaactc tgtcctcaag tttgaacagg cacagatgtt      900

ggatccttat ctgataaaag gaatggatgt atatggctac ctactggcac gagaagggcg      960

gctagaggat gttgagaacc ttggatgccg ccttttcaat atctctgatc agcatgcaga     1020

accgtgggtg gtttctggct gtcacagctt ctatagcaaa cgctactccc gggccctcta     1080

tttaggagcc aaggccattc agctgaacag taatagtgtt caagctctgc tacttaaggg     1140

agcagcactt aggaacatgg gcagagtcca agaagcaata atccactttc gggaggccat     1200

acggctcgca ccttgtcgct tagattgtta tgaaggtctt atcgaatgtt acttagcctc     1260

caacagtatt cgagaagcaa tggtaatggc taacaacgtt tacaaaactc tgggagcaaa     1320

tgcacagacc cttacccttt tagccaccgt ttgtcttgaa gacccagtga cacaggagaa     1380

agccaaaaca ttattagata aagccctgac ccaaaggcca gattacatta aggctgtggt     1440

gaaaaaagca gaactactta gcagagaaca gaaatatgaa gatggaattg ctttgctgag     1500

gaacgcactg gctaatcaga gtgactgtgt cctgcatcgg atcctaggag atttccttgt     1560

agctgtcaat gagtatcagg aggcaatgga ccagtatagt atagcactaa gtttggaccc     1620

caatgaccag aagtctctag aggggatgca gaagatggag aaggaggaga gtcccacgga     1680

tgccactcag gaggaggatg tggacgacat ggaagggagt ggggaagaag gggacctgga     1740

gggcagcgac agtgaggcgg cccagtgggc tgaccaggag cagtggttcg gcatgcagtg     1800

agggggcggc agctccatgg ccgcagtggc ctgccctgct ctgagcactt ccgtggactg     1860

aaggaaccgt aggagcctgc tctcagaagg acaatgattc agcatgtgat tgcagcaggg     1920

gtctctgccc cctcgctccc aattcctagt cgtgacttca tttctaaaac agagcctgac     1980

caaccttcca tgtatctcca tcctcccctg ctccagccag ggaggactga gggagtgccc     2040

cgagacccac gcacatgttg gggcttctgg gccaagagta ctttttatat aactaatttc     2100

taaatccaaa agctcaagga atagacagtg ttctgtgaca tggattggtt tgaaggagtt     2160

acccaccatc ccagcacgat aatgtcatct cccaagttgg atggcagcac gatctggccc     2220

tagggagctt cctgttccca gaagtcattg tcctgggcta tccagatgtc cctagtaaat     2280

cttgcttcct tctgcaatgt tagtaatgcc ttaagctgac agttgctatt ttgcagaaca     2340

gttttcctct ttgcttagct agtaacttgc ctctgagcct gggctgatct gagaaacagg     2400

tgtgacaaga gcatgaacca gaggtgcacc tggggcagtt ccctaataaa actggtttgt     2460

acagtcatgg tgttggggtg atcagaatgg aagccctttt caaaatagac tcttagtatt     2520

tttgtcttat tcgcaatgca ttgattcagc cccagaatta tttgccagaa atagactttc     2580

ttcccctggt gttgggagcc aggagggttg gaaagctcag gaaccctgag ctggttcatc     2640

tgtttgcata ttgggtaggt taatttccct ggagcctgag agtctttggc cagatttcag     2700

ctgcgtctgc ctggctcttt tgctgcagct gtgagattgg ggtctggttc cagcagtctg     2760

tcactggtca gcctgagtat cacaccctga gctctggggc tgggagtttc ttcccacacc     2820

ctctcccttg tgccttaagt tgcgatggct ctgagtatac aattaatcgg aggtgagggg     2880

tgggtgtcac agctaatccc aaattcaaaa attagtccaa ggtgctgcaa aatataaatt     2940

tgatgtcagt agaaagtcgt atcctaaaat gtaaaaactg taagtgtaca gtagttaatg     3000

agctcagaac atctgataac tgcaatttaa aatgggcaaa aagtt                     3045


<210> 3623
<211> 768
<212> DNA
<213> Homo sapiens

<400> 3623
agtggcggag gctcggtcac ccgggtgagt ccccactccg gctgcccgcg tccaccaagg       60

agatgcgtgt tccctttccg gcttattgtc tgacagaccc tctgccttat cccgctggtg      120

tcactcgggt gggggaaacc gggctgcgga gaacgggccc tagaggagac taagctctct      180

tcctatccct agcctcgctg cttttctctt ttgaaataat aagactggct tttataaaac      240

attttcagat aggtaaagga aaacatgcct gccacacgga agccaatgag atatgggcat      300

acagagggac acacggaggt ctgttttgat gattctggga gttttattgt gacttgtgga      360

agtgatggtg atgtgaggat ttgggaagac ttggatgatg atgatcctaa gttcattaat      420

gttggagaaa aggcatattc atgtgctttg aagagtggaa aactggtcac tgcagtttct      480

aataatacta ttcaagtcca cacatttcct gaaggagttc cagatggtat attgactcgc      540

ttcactacaa atgcaaacca tgtggtcttt aatggggatg gtactaaaat tgctgctgga      600

tctagtgatt ttctagtcaa aattgtggat gtgatggata gcagccaaca gaaaacattt      660

cgaggacatg atgcccctgt tttaagtctt tcctttgatc ctaaggacat ctttctggca      720

tcagctagtt gtgatggatc tgtcagagtg tggcaaattt cagatcag                   768


<210> 3624
<211> 473
<212> DNA
<213> Homo sapiens

<400> 3624
cctggaaacc caccgagaac ctccaccctc tgacaccatg gtcaactcct gttgtggctc       60

tgtgtgctct gaccagggct gtggcctgga gaactgctgc cgccccagct gctgccagac      120

cacctgctgc aggaccacct gctgccgccc cttgtgctgt gcctcctctt gctgctaaat      180

ctctgctgtg aacacaccac ttccttatta cgtcctttcc tacagatgaa ggctctcatt      240

gcaaacatgc ggactgttca agagaattga tctgggtccc ataagcaaac ctcatcctta      300

gaaattctgt atttgcattc taccttttgt ccaaactccc ttccttccaa aggaattcat      360

tgacaatctc ctaataaatt gacaaattgt cctccaacat cctcccacct ctttgacttc      420

aggacattta ttcatcatgc ctaaggaatt tgaagattgc ctccatcatt tgt             473


<210> 3625
<211> 697
<212> DNA
<213> Homo sapiens

<400> 3625
tggtcggccc gagcggaccc tcgcggcggc catggcgtcg gtggtggaat acaagggcct       60

cagggccggc taccactgcg gctactgcga ttccaaggag ggcaaagcgt cctgcggcat      120

gtgggcacat tccatgacag tacaggatta tcaggatctc atagaccgag gatggcgaag      180

aagtggaaaa tatgtgtaca aacctgtcat gaatcaaaca tgttgtcctc agtacacaat      240

aaggtgccga cctttacaat ttcagccttc aaaatctcac aagaaggttt tgaaaaaaat      300

gttgaaattt ctagctaaag gggaggttcc caaaggaagt tgtgaggatg agcccatgga      360

ttccacaatg gatgatgctg ttgcgggtga ctttgcattg ataaataaac tggatataca      420

gtgtgatctt aaaacactca gtgatgacat caaagagagt ttagagagtg aaggaaaaaa      480

ttcaaagaaa gaagaacctc aggaattact tcagtcacaa gatttcgtag gagagaagtt      540

gggctctggt gaaccgtcac attcagttaa agttcacaca gttcctaagc caggcaaagg      600

ggctgatttg agtaagcctc catgtcgaaa agcaaaggaa atccggaaag aaaggaaaag      660

gttaaaacta atgcagcaga acccagctgg agaactt                               697


<210> 3626
<211> 859
<212> DNA
<213> Homo sapiens

<400> 3626
gggcggcaga gctggagtga agggagctag tggtaaaggg agctggtgga ggggtggcgg       60

caggggtaag gggcagggga caccctctag acggagagcg ggctccgagg tcctggctgg      120

ccctcggtgc gcccgcccct gtgttggtcc cacaatccct ggcaatgaga ggccagggtt      180

tattggacag agtcagttgt ggggttcaga gggtcagcaa tcaatcaatc ctccgaatcc      240

agagatttag acccagtcgt ccgtattagg actggagggg ggtcaatagg ttcagtgttt      300

gagatgccaa gggaacctgt cttttgattt ggggttcaac atacagagtt taggtagcag      360

tcaccattat gctcaaagcg gtgatcctga ttggaggccc tcaaaaggga actcgcttca      420

gacctttgtc ttttgaggtg cccaaaccat tgtttcctgt ggcaggggtc cctatgatcc      480

aacaccatat tgaagcctgt gcccaggtcc ctggaatgca ggagattctg ctcattggct      540

tctaccaacc tgatgagccc ctcacccagt tcctagaagc cgcccagcag gagtttaacc      600

ttccagtcag gtacctgcag gaatttgccc ccctaggcac agggggtggt ctttaccatt      660

ttcgagacca gatcctggct gggagccccg aggcattctt cgtgctcaat gctgatgtct      720

gctccgactt ccccttgagt gctatgttgg aagcccaccg acgccagcgt caccctttct      780

tactccttgg cactacggct aacaggacgc aatccctcaa ctacggctgc atcgttgaga      840

atccacagac acacgaggt                                                   859


<210> 3627
<211> 568
<212> DNA
<213> Homo sapiens

<400> 3627
agaggtgacg cttctttggg ggcgggctgg agttttctgg ccgtgaatgg cagagcgcta       60

atggccgcct ccaatgtggc ccaatcagaa agaaaggaag gctgggaact aagaagctat      120

tggttggtga tccctggacc aatcggagga gccgtgattt ggcgggagtc ttgaccgccg      180

ccgggctctt ggtacctcag cgcgagcgcc aggcgtccgg ccgccgtggc tatgttcgtg      240

tccgatttcc gcaaagagtt ctacgaggtg gtccagagcc agagggtcct tctcttcgtg      300

gcctcggacg tggatgctct gtgtgcgtgc aagatccttc aggccttgtt ccagtgtgac      360

cacgtgcaat atacgctggt tccagtttct gggtggcaag aacttgaaac tgcatttctt      420

gagcataaag aacagtttca ttattttatt ctcataaact gtggagctaa tgtagaccta      480

ttggatattc ttcaacctga tgaagacact atattctttg tgtgtgacac ccataggcca      540

gtcaatgtcg tcaatgtata caacgata                                         568


<210> 3628
<211> 991
<212> DNA
<213> Homo sapiens

<400> 3628
actctggtgg tttcaggaag ggatgatcca ccaacacatt ctcagccaga cagtgatgat       60

gaagcagaag aaatacagtg gtctgatgat gagaacacag ccacgcttac ggcaccagaa      120

tttcctgagt ttgccactaa agtccaggaa gctatcaatt ccctcggggg cagtgtcttt      180

cctaagctta attggagtgc cccaagggat gcgtattgga tagcaatgaa tagttctctg      240

aaatgtaaaa ccctcagcga catctttctg cttttcaaga gttccgattt catcactcgt      300

gacttcactc agccgtttat tcattgtact gatgattctc cagatccatg tatagaatat      360

gagctcgttc tccgaaaatg gtgtgaattg attcctgggg ctgagtttcg atgttttgtc      420

aaggaaaaca agcttattgg tatttctcaa agagactaca cacaatacta tgatcatatt      480

tctaaacaaa aggaagaaat tcgcagatgc atacaagact ttttcaagaa acacatacag      540

tacaaattct tagatgaaga ctttgtgttc gatatataca gagacagtag ggattcccca      600

gctttccgtt gcacaaacag tgaagtgaca gtccagccca gcccctattt gagttaccgg      660

ctacccaagg actttgtaga cctctctact ggggaggacg ctcacaagct aatagacaaa      720

tcagcaggag gacgactgat gagcgtactg gaactggaga agaggaggcc ccgccccacc      780

gctccgggag ctgctcatca gccgcaactt cctgccgacc ctgatgcggg tgggccgagc      840

agtgtggaca tcagccactt tttatattca tgtacattca cctggggaaa aaaacggagg      900

gactttgcta cttgtaaaaa taacataata aatagatctt aaacatagga aaaccatact      960

gttctgataa taaaatgctt tctatgaaat a                                     991


<210> 3629
<211> 1499
<212> DNA
<213> Homo sapiens

<400> 3629
cgcgacgggc cacgcacgtc cgggcgtcca gttcggggca gcttctccgg ctgggtggca       60

accaactata tctgaggacc agagccattt tggggcacca gagcttgtga cctctccatc      120

tccacccagc tgggtccagg ggccactctc agcactcacc tcagcagctg acatcataaa      180

gcagacttgg gaacctggaa gcactctgga gaacctttcc ctgagacatg gagctttggg      240

gccgaatgct gtgggccctc ctgtctggcc cagggaggag gggaagtacc cggggctggg      300

ccttcagctc atggcaaccc caaccacctc tggctgggtt atccagtgcc atagaactgg      360

tcagccactg gactggggtc tttgagaaga ggggtatccc tgaggcccgg gaatccagtg      420

agtacatcgt ggctcatgtc cttggagcca aaacatttca gagcctgagg ccggcacttt      480

ggacccagcc cttgacctct cagcaactac agtgtatccg ggagctgagt agccgtcgat      540

tgcagaggat gccggtgcag tacatccttg gagagtggga cttccagggg ctcagcctaa      600

ggatggtgcc cccagtgttt attcctcggc cagaaacaga ggaactggtt gagtgggtgc      660

tggaagaggt ggcccagagg tcccatgctg tgggatcccc aggcagcccc ctcattctgg      720

aggtgggctg cggatcagga gccatctccc tcagcctgct gagccagctc ccccagagcc      780

gagtcattgc tgtggataag cgggaagctg ctatctctct gacccatgag aatgctcaga      840

ggcttcggtt gcaggacagg atttggatca tccacctcga catgacctca gaaaggagct      900

ggacacacct gccctggggc cccatggacc tgattgtcag caaccctccc tacgtcttcc      960

accaggacat ggagcagctg gcccctgaga tccgcagcta tgaagacccc gcggccctgg     1020

atggtgggga ggagggcatg gacatcatta cccacattct ggccttggca ccccggctcc     1080

tgaaagactc tggtagtatc ttcttagaag tggacccaag gcacccggag cttgtcagca     1140

gctggcttca gagccggcct gacctgtacc ttaatcttgt ggctgtgcgc agggacttct     1200

gtgggaggcc ccggttcctg catatccgga ggtctgggcc atagcatggc tgccctgtgg     1260

atgccttgtc agtgccgcca gcctgaccag aggggaggtg gatggcactt tccagagccc     1320

aggttcttat ggcatttccc agggttctgt gatttcccca tgctctgcat ttctaggata     1380

tttctaggac acctggattg gctccatcac atcagagtgg ctgagggcag ttgctctgtg     1440

ttggtgaaat tgctgtgggg gtatcggggg atatggccag taaagtattg agagactaa      1499


<210> 3630
<211> 1280
<212> DNA
<213> Homo sapiens

<400> 3630
cgcagtactg gacccgagcg cgacggtgcg gctggcggac ccgggctggc ttgtggggaa       60

acgaaactga gggaggaggc ggcggctctg gcagcggcgg cgacagtgtc ggcctgaccc      120

cccctccgct ccccggcagc tcgctctctc ccctcagctt aacgatgaag aggagaactg      180

acccagaatg cactgccccc atcaagaaac agaaaaaaag agttgcagag cttgccctga      240

gcctcagctc cacgtccgat gatgaacctc cctcctctgt cagtcatgga gcaaaagcat      300

ctactacaag ccttagtggg tctgatagtg agaccgaggg gaaacaacac agctctgact      360

cttttgacga tgcattcaaa gcagactctc ttgtggaagg aacttcttct cgctattcca      420

tgtataatag cgtctcccag aagcttatgg ccaagatggg cttcagggaa ggtgaaggat      480

tgggtaaata cagccagggt cggaaggaca tcgttgaggc ttccagtcag aaaggtcgaa      540

gaggcttggg tctgacactc cggggctttg accaggagct gaacgtggac tggcgagatg      600

agccagagcc cagtgcttgt gagcaggtgt catggtttcc agaatgtacc actgaaattc      660

ctgacactca ggaaatgagc gattggatgg tggtgggaaa gagaaagatg attattgaag      720

atgaaacaga gttttgtggg gaagagctgc ttcacagtgt gttgcagtgt aagaagccac      780

tggtgaagga ccgggaagct gagcttctgt actttgctga tgtctgcgca ggcccaggtg      840

gcttctcaga gtatgtgctg tggaggaaga agtggcatgc aaagggcttt ggaatgactt      900

tgaagggccc taatgacttc aagctggagg acttctactc tgcttccagt gaactcttcg      960

aaccctacta tggtgagggt gggattgatg gagatggaga tatcacccgc ccagagaaca     1020

tctctgcttt tcggaatttt gtcctggata acacagatcg caagggtgtc cattttctga     1080

tggctgatgg gggtttctcg gtggaggggc aggagaacct gcaggagatc ctcagcaagc     1140

agctgcttct gtgtcagttc ctcatggcgc tgtccattgt ccggacagga ggccacttca     1200

tctgtaaaac ctttgacctg ttcacaccgt ttagtgtggg gcttgtctac ctgctgtact     1260

gctgctttga acgagtttgt                                                 1280


<210> 3631
<211> 757
<212> DNA
<213> Homo sapiens

<400> 3631
cacagcttgc atcaatggtg tggaataacc caagtcagca acaatttatg caatttggag       60

gaagctctgg atcacagttg cctcaaatcc agacagatgt tgtacttcca tcatgcaaaa      120

aaaaagctcc tgctgaaact cctgtgaaag aaagactttt tattgtgttt aatcctcatc      180

ctttaccttt agacgtatta gaagatatat tctgtcgttt tggtaacctg atcgaagttt      240

accttgtgtc aggaaaaaat gtggggtatg ccaagtatgc cgatagaata agtgctaatg      300

atgccattgc cactctacat ggaaagattc tgaatggggt gagacttaaa gttatgctgg      360

cagattcgcc aagagaagaa tctaacaaac ggcaaagaac ttactgattc ttgagtggcc      420

ctgaagctgc actatgttgg aggtttcctt gactaagaga accacatgcg gcattcagct      480

cagtagggga gtcataaaag atctcgcctc tgaccagaag agtatgaatg acaaaggtga      540

cataaccagc acagaaagat gtcttagcct ctgcacatca gctgatttag aatacttatg      600

tagatagcgg ttggggtcgg gggggtgcgg aatgttcttt tcagcttctt tgccctgaga      660

actttgatct tattgcaagg aagtccctta ccctcttcta ccctagatct gatggacctc      720

ctgggatttc ctggggaaat gaaatgagtc taacacc                               757


<210> 3632
<211> 4222
<212> DNA
<213> Homo sapiens

<400> 3632
ccctgtctct actaaaaata caaaaaaatt agctggacat ggtggtgggt gcctgtaatc       60

ccagctactc aggaggctga ggcaggagaa tgacatgaac cttggaggcg gagcttgcag      120

tgagcccaga tggcgccact gtgctccagc ctgggcgact gagcgagact ccgtctcaaa      180

aaaaaaaaat tctttcattt atttagttac ttttagagat agagcctccc gctgttgccc      240

aggctggagt gcagtggcag tcatagctta ctgcagcttt gaactcctgg gctcaaatga      300

tcctcctgcc tcagcctctc cagtagctgg gactgactac aggcacgtgc caccacaccc      360

agctaatttt tatttttatt tttatttttt tgagacaggg ttttactctg tcacccaggc      420

tagagtgcag tggtgagatc atggctcact gtagcctctg tctccggggc tcaatcaatc      480

ctcccacctc agcctcccca gtggctggga ttactggtgc acaccaccat accctgctaa      540

ttgtatttat ttttagtaga gatgggattt tgccatgttg cccagactgg tcttgagctg      600

ctgggctcaa gcgatcttcc catcacagct tcccaatgtg ctgggattac aggtgtgagc      660

cactgtacct ggccagcttt acttctttta ccagcactcc tgattttata aatagtgagg      720

cttatcaacc ccatttctac ccaaatcttc tggtagactt gagtatagta gggcttcata      780

ggtagcagcc ctgtccctgt cctattatga tggtagctgt tgtgatgtgg cgatctctga      840

tctagaaacc cctgaggggc cattgtggcc tgcccagtct cccggccacg gttgaaacca      900

gacgtgcagt ggggctgacc cctgtgcccc accccagagt catgccagcg tgggtggtgg      960

ggcattctct gggatgaatg atctggatcc catagccatc tgtgtcctgt ttgaggaatg     1020

ggaccctcaa acagagaaca gccaagatgc tcaagcaggt gtgtgcttgg gccagactct     1080

gcagcctttg gtttgggact tgactgccat tcactgaagg ggcccaggaa atgggcagct     1140

cacatggtgt tgctgggtgt ccagctgcgg cagtttagca gaggaggact tgtaatgaga     1200

tggtagcttc ttataggcta agacatgatt tttctgttct tttactacct cctgcacctt     1260

ctagaactgt tccttctctg atgctgtttt cctttcttcc agtgatttat ctctagggtc     1320

tccatagcag gggaggtagg gtcagactcc tgagatggct gatgtcctac cctgccccca     1380

accaggggcc ccaggagact cctttttctt actgcaactt tggcctcctc agtctgcaga     1440

tctccagggg agcccaccag cctagtcaac atggcctcgg aagacattgc caagctggca     1500

gagacacttg ccaagactca ggtggccggg ggacagctga gtttcaaagg caagagcctc     1560

aaactcaaca ctgcagaaga tgctaaagat gtgattaaag agattgaaga ctttgacagc     1620

ttggaggctc tgcgtctgga aggcaacaca gtgggcgtgg aagcagccag ggtcatcgcc     1680

aaggccttag agaagaagtc ggagttgaag cgctgccact ggagtgacat gttcacggga     1740

aggctgcgga ccgagatccc accagccctg atctcactag gggaaggact catcacagct     1800

ggggctcagc tggtggagct ggacttaagc gacaacgcat tcgggcccga cggtgtgcaa     1860

ggcttcgagg ccctgctcaa gagctcagcc tgcttcaccc tgcaggaact caagctcaac     1920

aactgtggca tgggcattgg cggcggcaag atcctggctg cagctctgac cgaatgtcac     1980

cggaaatcca gtgcccaagg caagcctctg gccctgaagg tctttgtggc tggcagaaac     2040

cgtctggaga atgatggcgc cactgccttg gcagaagctt ttagggtcat cgggaccctg     2100

gaggaggtcc acatgccaca gaatgggatc aaccaccctg gcatcactgc cctggcccag     2160

gctttcgctg tcaaccccct gctgcgggtc atcaacctga atgacaacac cttcactgag     2220

aagggcgccg tggccatggc cgagaccttg aagaccttgc ggcaggtgga ggtgattaat     2280

tttggggact gcctggtgcg ctccaagggt gcagttgcca ttgcagatgc catccgcggc     2340

ggcctgccca agctaaagga gctgaacttg tcattctgtg aaatcaagag ggatgctgcc     2400

ctggctgttg ctgaggccat ggcagacaaa gctgagctgg agaagctgga cctgaatggc     2460

aacaccctgg gagaagaagg ctgtgaacag cttcaggagg tgctggaggg cttcaacatg     2520

gccaaggtgc tggcgtccct cagtgatgac gaggacgagg aggaggagga ggaaggagaa     2580

gaggaagaag aggaagcaga agaagaggag gaggaagatg aggaagagga ggaagaagag     2640

gaggaggagg aggaagaaga gcctcagcag cgagggcagg gagagaagtc agccacgccc     2700

tcacggaaga ttctggaccc taacactggg gagccagctc ccgtgctgtc ctccccacct     2760

cctgcagacg tctccacctt cctggctttt ccctctccag agaagctgct gcgcctaggg     2820

cccaagagct ccgtgctgat agcccagcag actgacacgt ctgaccccga gaaggtggtc     2880

tctgccttcc taaaggtgtc atctgtgttc aaggacgaag ctactgtgag gatggcagtg     2940

caggatgcag tagatgccct gatgcagaag gctttcaact cctcgtcctt caactccaac     3000

accttcctca ccaggctgct cgtgcacatg ggtctgctca agagtgaaga caaggtcaag     3060

gccattgcca acctgtacgg ccccctgatg gcgctgaacc acatggtgca gcaggactat     3120

ttccccaagg cccttgcacc cctgctgctg gcgttcgtga ccaagcccaa cagcgccctg     3180

gaatcctgct ccttcgcccg ccacagtctg ctgcagacgc tgtacaaggt ctagactcaa     3240

agcctctccc atcccttggc ctggaccagt gagctgggga gggactcgga tgaactgagg     3300

cgcagcctac gccattgcct tggacaggac tctggccaca ggcagggcgg gtctgtgtcc     3360

catgtgtcct gtcagtcccc tgagtatgtg tgtgggtgtg gcgcatgtgc aggtctgtgc     3420

ctcctgtcgg gatttgggtt ttaacgtctt ctgctggccc agccctgctc tgttgtgggg     3480

agttggcccc caggggaaag ggctgtgagc tgctccgcca ttaaactcac ctccacctga     3540

gggcgctctg ctgatctccg cctgggccct gatggccgtc cccacccacc tgccttccgg     3600

cccggctccc tggcggagcc agaacccagg gagttgcccg cgtgctgtcc ttcccctctg     3660

tgttgtgatt gggttgtttc ctgccctgcc tggggctgct tctcgtcacc aagccctggt     3720

cctgcggcag ctgtcacccc taccatccat accactgtgc tgaccgctca gcctgaagag     3780

cagagaatgc catgggtggg actgtggggg tcggatcgtg gggttgttgg cagagggcaa     3840

ccctgggccc cacaccgtgt ggacaggcag acaccagatt gtccaggagc aggagctgct     3900

gggactgcgc tggccccgga cctagtgggc cttctcctgg ctgctgagat gtcgtctgtg     3960

actggcctgg ctggaggggg agtgttgaca acccaaagct gttctccagt ctggggaggg     4020

agaggcaggg tccccaatgt ccgagctgca tctggacgct gctcttaaag gacctcctgg     4080

ggcaggggag cggtagggtc tggactgggc agatgctgta tgacctccct gagcacccgt     4140

gactgcccca tgctttcccc tttgtgctct gtgtgtgtct gggctgtgcc cgggggcttc     4200

acaaataaag tcgtgtggca gc                                              4222


<210> 3633
<211> 4599
<212> DNA
<213> Homo sapiens

<400> 3633
actttgccag agcggccggg tccccattcc cattccttca aatccccttt ttcccggcag       60

ccgacctgta gacccaaggg agacaggttg aagctagaaa gagtcggggc agcagctctg      120

gtaggggagg gagcatccaa aacctctggc ttctgagcgc ctctcctgcc gcccatccac      180

aaagcccccc acagcctggc ggctgccctc gaccccgcaa aacaaaggac ttcagaggct      240

ggacctacag acccagatga gaaggcaaaa gcgtagggag gagcggcagg agatgggaag      300

ggcgggcccc gctcggagca gctgccgctt cctcccaaag tcccacgagg ggcctgagtc      360

acgggccacc gccctgggtc ggcgagctgg gggaagggat ctggacacct ggcgtgtccg      420

ggcgggaagc tggtgagggc ccctggggac agagcggagg accagtggtt ggggcgagaa      480

gagggcagtc ccgcagcgag tcccacgcgg ggtgggaggg atctaggccc cgccctctcc      540

tcggctccgc cctgcgcccc cttccctctc ctcattgtcc ttagacaaag cggtcgccgc      600

ccccgcccgg ccccctggtc tctgtctccg tccctcctcc tttgctgcct ctttccctcc      660

tcctctccct ccctcctccc ctccctccag tctccggatc tccctcggtc cctctctcct      720

cctcttcctc tctctggacg cccggctcct ccgcaccccc tcccccgggg gtcccgcggc      780

ctgtgagttg actgaggggc tcagacttgg ggagtgggtg tctcctcgcc cctgtccttg      840

ctcccgtccc tggcccggac cttggctgtc tcctctttgt gccgagattg tcagtctgtg      900

cggctacagc ggggtggaga cggccggctc tgtcacggct tcatgagagc ggggacgggg      960

cgcaggactt gcaggcgccg gggagaagag acatggagcc ggcccttggc actctggggt     1020

cgcgtggggc agtcggtggg ggaggcaggc ggtggtgaca ggacagggtg ggggtggacg     1080

ccagggttct gggaacgcgc tggcagccct gacgcccggg ttccgaaagt ctcgggggtg     1140

ggtatttccc ccgacccgcc tcgggggcgg agtgcggggc agaggggtgg gggctgggga     1200

gaggcgtggc ccgagcggtg ctggaagcgg agccgggacc tttggggccc gcgctgagac     1260

gcgcccggct gctgccgccg ccctcctttc ccctcttccc tggtttccct tctcctctag     1320

acctgttcgc tctccgcccc tccttgcctc cccaacaccc cctcaggtcc cgttgcctcc     1380

tggtcctttc agggattcct ggtccttcct tcccacacta gcctccctgg ggtatcgctg     1440

aggcagcctg gcctgcaccc aggttcccct cacccctgcc acatttctct cttctccctc     1500

acgccaactt tccttttcgc ccttctctct ctttctcaca tcctagagac ggtctttaat     1560

acgcattaac cctgtgctgc cacatctggc tcctgccctc attgcctcca atccggactc     1620

ttcctctcac atcaccccca ccacccccaa cttgggctca caacttctct tcactttttc     1680

catttcccca gttctctgcc ttccgtcttt ccctctgtcc tcatccttag cccctctgcc     1740

ctgctttgtg tcccacctct ccccctccac ttcctctcct cccaccctca gtctcacccc     1800

cgggctgtct cactctctgg agcctctcct tcctgttctc tgtccccagt gctccctacc     1860

ctcacctcaa gacgaccatg gccaccatcc cagactggaa gctacagctg ctagcccggc     1920

gccggcagga ggaggcgtcc gttcgaggcc gagagaaagc agaacgggag cgcctgtccc     1980

agatgccagc ctggaaacga gggctcctgg agcgccgccg ggccaagctt gggctgtccc     2040

ctggggagcc tagccctgtg ctagggactg tagaggctgg acctccagac ccggatgagt     2100

ctgcggtcct tctggaggcc atcgggccag tgcaccagaa ccgattcatc cggcaggagc     2160

ggcagcagca gcagcagcaa caacaacgga gtgaagagct gctagcagag agaaagcctg     2220

ggcctctgga ggcccgggag cggagaccca gccctgggga gatgcgggat cagagcccca     2280

agggaagaga gtcaagagaa gagagactaa gtccgaggga gaccagagag aggaggctgg     2340

ggataggggg agcccaagag ttgagcctga ggcctctgga ggctcgggac tggaggcaaa     2400

gcccaggaga ggtgggagac aggagctccc gactgtcaga ggcatggaaa tggaggctga     2460

gtcctggaga aactccagag cggagtctga gactagcaga gtctcgagag caaagcccca     2520

ggagaaaaga ggtggaaagt agactgagcc caggggaatc tgcctaccag aagttgggcc     2580

tgacagaggc ccataaatgg agacctgact ccagagagtc tcaggaacag agtttggtac     2640

aactggaggc aacagagtgg aggctgaggt caggagaaga aagacaagac tactcggaag     2700

aatgtgggag aaaagaagag tggccagttc caggggtagc tccaaaagag actgcagagc     2760

tgtccgagac cctgacaagg gaggcccaag gcaacagttc cgcaggagtg gaggcagcag     2820

agcagaggcc tgtggaagat ggcgagaggg gcatgaagcc aacagaaggg tggaaatgga     2880

ccctgaactc cgggaaggct cgagaatgga cacccaggga catagaggct caaactcaga     2940

aaccagaacc tccagagtca gcagagaagc ttctggaatc tcccggtgtg gaggctggag     3000

aaggggaggc tgagaaggag gaggcggggg ctcagggcag gcctctgaga gccctgcaga     3060

actgctgctc tgtgccctcc cccctcccac cagaggacgc tgggactgga ggcctgagac     3120

agcaggaaga ggaagcagtg gagctccagc ccccaccacc agcccctctg tctcccccac     3180

ccccagcccc aactgccccc caacctcctg gggatcccct catgagccgc ctgttctatg     3240

gggtgaaggc agggccaggg gtgggggccc cccgccgcag tggacacacc ttcaccgtca     3300

acccccggcg gtctgtgccc cctgcgaccc cagccacccc aacctctcca gccacagttg     3360

atgctgcagt cccgggggct gggaagaagc ggtacccaac tgccgaggag atcttggttc     3420

tggggggcta cctccgtctc agccgcagct gccttgccaa ggggtccccc gaaagacacc     3480

acaaacagct taagatctcc ttcagcgaga cagccctgga gaccacgtac caatacccct     3540

ccgagagttc ggtactggag gagctgggcc cggagcctga ggtccccagt gcccccaacc     3600

ctccagcagc ccaacccgac gacgaagagg atgaggaaga gctgctgctc ctgcagccag     3660

agctccaggg cgggctgcgc accaaggccc tgattgtgga tgagtcctgc cggcggtgac     3720

catcttccaa catagggata tacctccctc cttcttataa ctgaagatcc tggagcccgg     3780

aagattcagg gcagacagac cctgataatg agcctggcag ggaagggcaa ccaacatctt     3840

gtaacttgct ttccccaccc tgtttctggg ggcagagcca attgcccaat ttctacccta     3900

atccaaagtc cctggtgtgg gtggggttaa acgtgctggt gcatcctagg tcatccaaga     3960

gtgagcgcca agtcctgaga aggggcacag aactccctgg agggtggaga tggagcacct     4020

gccccccatg gcagggtaca ctctccccac agccttcctc cccaccatcc cgtggggact     4080

ctcgggattt aagcactcgt ctctctggga ggcccagacc ccactccatt tataggcaca     4140

tctccttcat ttcctaggtc actgcccctt tgtttacagc tcctgcctcc tcccttgacc     4200

acagcctggt ttacaaattc catcagctcc cagccccacc tgccaaagtc ccaggtttac     4260

aagccacgct tacttgctgt gtctgcgtgg aattctctcc tctgtcccct ccagtctcct     4320

cattggagtg acctgaaggt gtggcttcct ccactttttc tcagtattac tttgccttag     4380

ttttccccaa gagggaaggc tggaactctt aactctgtac cccttgatag ttatttaatt     4440

ctgtttctcc tagtggttca caattgaact gaattgagat ggtgtcgggt ggctaaggag     4500

acacctcacc tctccttccc cattgtgccg cctttatcaa ttgcctgttt tgttttgttt     4560

gttttttaac tttccataat aaaatggagt tctcttcaa                            4599


<210> 3634
<211> 477
<212> DNA
<213> Homo sapiens

<400> 3634
atgacccact gttgctcccc ttgctgtcag cctacctgct gcaggaccac ctgctgcagg       60

accacctgct ggaagcccac cactgtgacc acctgcagca gcacaccctg ctgccagccc      120

gcctgctgtg tgtccagctg ctgccagcct tgctgccgcc caacttgctg tcaaaacacc      180

tgctgtagga ccacctgctg ccagcccacc tgtcccacct gctgtgggtc cagctgctgt      240

ggccaaacca gctgtgggtc cagctgtggc cagagcagct cctgtgcacc tgtgtactgc      300

agaagaacct gctactaccc cacgactgtc tgcctgcctg gttgcctaaa ccagagctgt      360

ggctccaact gctgccagcc ctgctgccgc ccagcctgct gtgagaccac ctgctgcagg      420

accacttgct tccagcccac ctgtgtgtcc agctgctgcc agccttcttg ctgctga         477


<210> 3635
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 3635
gggagattac ggggcgggga cgagctgtcg cgctggttgc tcgtgcagga gcgggacccg       60

gaacagaccg ccgtgagaga ggaggggtgc cggccgggat tcgcggcccg gagctcggga      120

ccggttgctt cattccagcc tcgcagtcac ctctgtgccc tgctggttgt cttcccagcg      180

ctgctgtagt tgccttccat ggatctatag gagagcaagt cctccaggag aagaagtcct      240

caccagtgaa cggagacctc tctgaactaa ggataccatg gccacgtcag ccccactacg      300

gagcctggaa gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac      360

cattgactgt ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg      420

gagccgcccc gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt      480

gtggcaactg gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca      540

gccgggagag gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa      600

gctgcactac tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg      660

ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa      720

aatcctgaac cacctgagta ccctaaggag ggacagagac aaaattcagg gcttccaggc      780

aaagggagaa gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat      840

tgtggctgag tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga      900

acagctggcg aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg      960

cgtcggggag cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca     1020

gccagctgca gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa     1080

gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga     1140

taaactcctc tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt     1200

ggaatataag acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct     1260

gtcagaggac tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc     1320

ccagcagttt gactgtgagc ctggggtgct aggcagcaag ggcttcacct ggggcaaggt     1380

ctactgggaa gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga     1440

ggaggaagag ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga     1500

cgactgggaa acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga     1560

ggaagaggag gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag     1620

gaagggagac ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc     1680

cggcatctgg gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag     1740

agtgggcatc gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca     1800

ggaactcatc tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct     1860

caagtggcca ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc     1920

caaccctcag atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc     1980

ctggcctaag cacctggagc aggggacccc atatccactg gtagccacct ccccattgct     2040

gtggccccct gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt     2100

ttcccacctc ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct     2160

ttcctttttg accacgacct tggccccagc tctgcactct ctggaataag ggcccgatgc     2220

agcattttct tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc     2280

attttgctgt ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc     2340

ttccctggca ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa     2400

tgctgaaaat aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag     2460

cgcatatcat ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc     2520

atatttccat agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat     2580

ccagacatac acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga     2640

ttggtccttg tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc     2700

aaaaacacca agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc     2760

gggttcccca gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact     2820

ttcctaggag agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc     2880

ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa     2940

cctctgtcca ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa     3000

ttgatctccc agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa     3060

gttttaagtc ctccaccctg ttctaagaga ctgttccaac ggctctgggc ctcagtggtc     3120

acttgaccac cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca     3180

catgtacatc ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta     3240

tactactctt gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat     3300

aaagacttgt tgaatgaa                                                   3318


<210> 3636
<211> 9497
<212> DNA
<213> Homo sapiens

<400> 3636
agaatgcagc gcatggcgcg tcattgaaga gagaccatga tggcggcggc gctggggccc       60

ccagaagtga tcgctcagct ggagaacgcg gctaaagttc tgatgcaaac tctggcctgt      120

tctattctga ctgcgctatt gagtgaattt tcaagttcaa gtaaaactag caacattgga      180

ttgagcatgg aattccatgg taactgcaaa agagtttttc aggaagaaga ccttcgtcag      240

atcttcatgt taactgttga agttctgcag gagttcagca ggcgggaaaa cctcaatgct      300

cagatgtctt cagtatttca gcgttacctt gcactcgcca atcaagtctt gagctggaac      360

tttcttcctc caaaactggg cagacattat atagctatgt ttgaatcctc gcaaaatgtg      420

ctgttgaagc caacagagtc ctggcgggag actcttctgg acagcagagt tatggagctt      480

ttcttcacag tacatcgaaa aatcagagaa gattcagata tggcacaaga ttctctgcag      540

tgccttgccc agttagcttc tcttcatgga cccatcttcc cagatgaagg atcacaagtt      600

gattatctag cacacttcat tgagggatta ctgaatacta tcaatggaat tgaaatagaa      660

gattctgaag ctgtggggat ctccagcatt atcagcaacc tgataaccgt gttcccacga      720

aatgttttaa ctgccattcc aagtgaactt ttctcctcct ttgttaactg cctcacacac      780

ctcacttgtt cttttgggcg aagtgctgca ttggaagaag tgcttgataa agatgacatg      840

gtatacatgg aagcatatga taaattgttg gagtcctggt taactttggt tcaagatgac      900

aaacatttcc ataaaggctt ttttacccaa catgcagttc aagttttcaa ttcctatatt      960

cagtgccacc tagctgctcc agatggcaca agaaatttga ctgccaatgg tgtggcctct     1020

cgtgaggagg aagaaataag tgaacttcaa gaggatgatc gagaccagtt ttctgatcaa     1080

ctggccagtg taggaatgct aggaagaatt gctgcagaac actgtatacc tcttctgaca     1140

agtttattag aagaaagagt aacaagactc catggtcagt tacaacgaca tcagcaacag     1200

ttacttgctt caccgggttc aagcactgtt gacaacaaaa tgcttgatga tctctatgaa     1260

gatattcact ggcttatttt agttacaggc tacctcttag ctgatgatac tcagggagag     1320

actccgctaa tacctccaga aataatggaa tattccatta agcattcatc tgaagttgac     1380

attaatacaa cacttcaaat tttgggatct ccaggagaaa aggcttcttc catcccaggg     1440

tacaacagaa cagattctgt gattaggctg ttgtctgcca ttctcagagt ttcagaagtt     1500

gaatctcgag caataagagc agatctcact catctactaa gtccccagat gggcaaagat     1560

attgtttggt ttttaaaacg ctgggcaaag acttatctcc tggtggatga aaaactgtat     1620

gatcagataa gtctgccatt cagtacagcg ttcggagcag atacagaggg ttctcagtgg     1680

ataattggct acctcttaca aaaagtcatc agtaacctct cagtctggag tagtgagcag     1740

gaccttgcaa atgacactgt gcagctcctt gtcactttgg tggaaagaag agaaagggca     1800

aacttagtaa ttcaatgtga gaactggtgg aatttagcta agcagtttgc aagccgaagc     1860

ccacctctta atttcttgtc aagtcctgtg cagaggacat tgatgaaggc tctagtctta     1920

ggaggttttg cacatatgga cacagaaacc aaacagcagt attggacaga ggttcttcag     1980

ccacttcagc agcgattctt aagagtgata aaccaagaaa acttccagca gatgtgtcag     2040

caagaggaag tcaagcagga aatcactgcc acactagagg ccctgtgtgg cattgctgag     2100

gctacccaga ttgacaacgt agcaatcctg tttaattttt taatggactt ccttaccaat     2160

tgcattggat tgatggaagt ttacaagaat accccagaga ctgtcaatct cattatagaa     2220

gtttttgttg aagttgcaca taaacagata tgctatcttg gagagtccaa agctatgaac     2280

ttatatgaag cctgccttac tttgttgcaa gtgtattcta agaataattt agggcggcaa     2340

agaatagatg ttacagcaga agaagagcaa taccaagacc tgcttctcat tatggaactt     2400

cttactaacc tgctgtcaaa agaattcata gatttcagtg atacagatga agtgtttaga     2460

ggacatgagc caggtcaagc agcaaacaga tctgtgtcag cagcggatgt tgtgttgtat     2520

ggagtaaacc taattctgcc cttgatgtca caggatctct tgaagtttcc aaccctttgt     2580

aatcagtact acaaattaat cacatttatc tgtgagattt ttcctgaaaa aataccacag     2640

cttcctgagg atctgtttaa aagtctgatg tactccctag aattaggaat gacatcaatg     2700

agttcggagg tttgccagct ttgcctggag gccttgacac cgttagctga acagtgtgca     2760

aaagcacaag aaacagactc accacttttt ctagcaacac ggcactttct taagctggtt     2820

tttgatatgc tggttttgca aaagcacaac acagagatga ccactgcggc tggcgaagct     2880

ttctacacgt tggtgtgttt gcaccaggct gaatattctg aactggtcga aacattacta     2940

tcaagtcagc aagacccagt tatttaccag agattagcag atgccttcaa caagctcact     3000

gcaagcagca ctcctcctac gctggatcgg aagcagaaga tggccttctt aaagagttta     3060

gaagaattta tggcaaatgt tggtggtctc ctttgtgtaa aataaacaac agaactttat     3120

gcttaattta gatcctttct gcaaagtgca ctgaattgct gaaagttgac ttgagtcttg     3180

tcctattcct cagttcattt ggccattttg gattttggag agcctgaaac tttgatatgt     3240

atgtaataca gtgaaacagg agaggtcaac ttggcatcag cttctgctgt taagtgttag     3300

ccacaatctg tcatatatat gtcttttaga ttctgaatgg tgatttaaaa ttttcaaaat     3360

gaaattccat atatgtgcaa acagatatgg gcaccacgaa atacatatgc agtgcctttt     3420

ttccttttaa cataggtggc tagccaaagt ttagaatttt tgtcattaaa tatgaaatgg     3480

atatatgcta ggcagtgttt ctcaaaatct ccatagatcg cctgcatcac ttgaggagct     3540

ggtgaaaagg cagattctta ggcccaactg tagaccttca gagtcagaat gtctggttgt     3600

tgggcccagg agtcttcatg ttaataagct tctccctttc gtcaccccaa aagttttgaa     3660

tcaatgaaag agacattgaa aactcttaag aggttttgtg ctttctagct tttcctccct     3720

ttgatgattg ggttttataa ttcagcagga aggggaaaca tcaccagggg tttgttggct     3780

ttttcttagc ttgctttctt gcttgcttgc tttcttgctt ttcttgcttt ctgtctctct     3840

ctttcttttc tctctctctc tcacatcaac ccagtgctgc aggttttgtg taatacaagt     3900

cactaatcat actctgatgc ctgaacttga ggaggaaaat acatgtatat ttttgttccg     3960

taaaaataac cttaggaact gtagccattt cattgcctta attttaagag gaaaatacaa     4020

aaacagctga tttgttttag taagaaacca cgtcttgatg cttcagagtt ggtttagggt     4080

gttagctgct atgaacctgt tgcccctttc gatcgtgtat ttatgtaggt ttatcagtga     4140

aatgaaaggc ttgtttccgt ctagtctaac tttttgagtg tgtttctatc cagccacata     4200

gcccatatct actctaaatg gcttgcttaa gcaataatta ttttaaagga tgtgaatcac     4260

tgattcacac agactattgc acgttggggc attaggggca ataattctta tccagacatg     4320

ggagccagtg aatttaattt cagagattaa aaattcactt tagatcctct agtttgatct     4380

cttaatcagg atttttatac agctgccagg ctcccctaat tcagtgtgcc agcttacaat     4440

gtggaaatga aagctaattt atacacagca ggcatatgaa actccactca ttgcagtact     4500

ttcacagcac agtgacaggt agaggactct ggcacaggtg cactcatgaa actctgcttc     4560

caccatgttc ctgacaccta tctattaaac cattctgcaa atacggtttt tctacctgat     4620

tgcatatagc atatgtgtca ttacatgtga tgctgtgcaa aactttgtat aattctgtgt     4680

tattaacagt taacaaaact ggagcatctg aattacatcc aacctgtgca tgtgatgtta     4740

ggtagatgtg aatgcagggc cttgggccat aacttacatt tctctcaatt tgattagctt     4800

tgagtcacaa ttaaggggaa gcaaaaacat cttgaaaaga ctgctaggaa ggaaattaat     4860

atcagtcatc cagaagtaca cgtttctgta ttttaaaaaa tactttgatg catttatttt     4920

taggtgtttt ttttttcccc ttaaaaaact tgaagtgata tgcagcagta atctatttgt     4980

tttgcattgt tcttggtgtt ttgtgtttcc cagatccctc aagctttctc agctgttgtg     5040

aattatgtgt atctgtgtgt gtgctaagta cagtctcttt accaaagggc actgaaacac     5100

acaattgact ggacaggtcc acgcgccatg acaaaactat aatcaagtta ttaaaactaa     5160

agaggagtgg gaaaggaatg ccttggtaag taaaaaggca tctatattta ataactttta     5220

tccagatggc aacatatttg caaaatttgc ccagatccta ttacaatact aaaaatagaa     5280

aatttcacct ccatattcct gaggtgtaat ttcattagac tagttttagt ttaaaaagac     5340

cttcttcaga ttggaccaaa taatacttat aagatcagca gaatgttgaa tattagctca     5400

ctggggtggg gagaagccac taccattttt taggtgatgg ggatgccact gagttgcaac     5460

ggctagacct tttcagggtg gttgtgtcca tgtttgcctg attggatgct tattcacttt     5520

gtgttttctt ttgttttatt ttgtccaatt ttgtctttag ctgtgtttat taacttctcc     5580

ggtcttgttt tgttttaatg ctcttggccc agtgggtgtc aagaacactg gcttaattca     5640

agtcagttga ttttttttct attaaaactg ttgttaaaat attttttaaa acaaaaacat     5700

tatttgtgcc ctcttttata tatgtcaaag ggacactgtc aagtatttca tttttagatt     5760

tttgttttat aaaatttctg ttgttcatat agtatccttt aacctctagt tttccataca     5820

tcctttgttt gtttctcatt ttattttcct tgacccattt atttcccaag gcacaatcac     5880

taaagacttt gtactttcac agtctgttaa tgtggtagca cctgtaactg tgttcttgtt     5940

ctgttaaaag gattgatttg cttttatagt ccttgtgctg gatgagtggc tgcctcagta     6000

gcaaaactac ctgacagtat ttgacagtgt cctttccagc accattattt gggtctttca     6060

gggtggccat ctctgttaga agacagtagc atgttaacat cactgcattg agtttttgtc     6120

tggtgtaaag tatgactttt aatgtaaaca aactgcaggt ttttttcaaa ctaattttaa     6180

gaatttagtc ttatttcgtt gtaaactgtg tatctaatta tattacatta ctctgttcag     6240

atgggatggt tactaccact tgtccatgat tttcatttga aaagcaagta tctatatcat     6300

ttccccccag tcagcattat ttaacactcc ccttaactgt ctttgaactt tctcttttaa     6360

caaaaatgtc aagtctttat agttgtaata tcaccatgtt tcccatttct gttaatactt     6420

ctatgaaccc ctaaagtatt gaagggaact agctgtcagt ttcaaggatt acaagtttga     6480

gtctcctagt attcaacatc attctgaacc ctgaaataat atttttctct gttaaacaat     6540

ttttatctgt ttgccacctc tgttgttaga ggtggttgtc aattgacctt actaagttag     6600

ctgtctttga tgaggaatta ttgttattgg ttcctgaata aaacattaac cttttaagtc     6660

agaaggaacc tcggtacttc ttaaggtttg tttgtgtttt ctaaaaccag agaataagga     6720

actgatttgg ctatgaggtt taacattata attttctgta agctttccca caaaaaaaca     6780

ttgttgattt gaggatataa taatgtttta atctttttaa aatataagtg gttattctct     6840

gacttggtaa ctatgttctg aaaacactgc atttaagaat ttttaaaaat tggttttcta     6900

aaattaaaat gtccaaatta ggcatattgc tgagctcaaa ttgatgtgaa atgccatggt     6960

tccagttgaa ttttaagcat attttcattt agatataaaa tatatgaagt atgctttgtt     7020

gattatagtg agaacccatg acatagttaa ccaaagaata tgtttggttc aaataaaaat     7080

agaagcttaa tactgggcat tcatactttt taaagagaat gaatgaagaa atcggtttcc     7140

tgctgtagtt ctctatgggt aagtcttagt aaagacgaga atgctgaagt cggccgtggc     7200

gattccctcc taggaactgg gaggtgtggc ttgcccatta cccgcttgaa gctcacatct     7260

ttaccctcct ctcccactgt ggtttgatct tcacctattc ccaggccctc ccagcaattg     7320

gagaggtgtc tttttttttg gttttggttt tttttctccc cgtctgcatt cttaggcctc     7380

ttagctatta ggaactgtca gatacatact agtagctaat tttcctagcc tgaaattata     7440

tactgcatct gcactatgta cctactaggg atctgacctc aagtgttttc tgagcccagg     7500

cttcctggtg tggtgtcttt taccacataa aattattaca aattgcaaat gttggtattg     7560

tgatttgatt atctgtacaa agaaagaagc tctatgcagt gagtttgtgg tttaatggtc     7620

acaaaaatgt tagcactgct accactcagc acgtgtaaaa ttttttaaat ttataaatat     7680

taaaatttta aacttacact aagacttttc agttttattt aaagacccag ggatgagtgt     7740

actgtttaaa tatttacctc tattaacata actaatgaag gtataaaatt gcatttagtt     7800

tttcagaaga tgctgcaata tgattttagg aaataaggct atgtattgag ccagttatag     7860

gctgaatatc aggttgataa aattttattt gtatttttaa aattcataaa tgggagttaa     7920

aatgtgtctt ttcactaaat atttttatta catttttgtt ttgaccatgt gtgatttgtt     7980

catgggtatt tagctagact cttttatgaa atgcattgaa atggtgctag tttgtttacc     8040

attataggaa gattgacact ggggacatta cacggtccta aaataatttt aaatttaaaa     8100

aaatgaagac atctgtacag ataaaaatca agatttgcat caccttctgg gagaacccgt     8160

ggtactcaca gaatatccag tattagaaat ataaaaattt tgtctatatt ttataatatt     8220

tatctcagcc cacagtctta gaaacagttt cacagttact agttaagtca ttatctttgg     8280

tgcatattta gtaaatactt ttagcaagtc attctttttg gcctttcagg gaaagtggtg     8340

aattaccata ttactgtgtg ctagatagat ccaccctttg cccagtgtta aatcttgtaa     8400

acatatgaag tgaaaagtta atttttaaag aaaatgcatc tttaaaatgt tcatttttaa     8460

cctgaatttg ctttgaatat tctttgattt gtaatgttgt tatttagctt atattgagat     8520

ttattccact ccaaaggtgg ataaagaaaa gttgtttaag aaaaccaatt agagtgtatt     8580

ttgaattttt gtttctttca ttaccaagtg tggggccata cacacaggct aatcatctgt     8640

catttgagac ccacagatga tttcaaaggt cccaaataaa tacacatcta taactgtttt     8700

ttaaaagaca tctttaatgg tgctctccaa aaatacaatt cggttgctta tgagtgatgc     8760

ctttgacagg ctgattagat tataaaacag ttttgttttt ttaaacatag ggtctcagat     8820

tgagtcttgt gcattctatg taatctcaaa tggcagttca gtttgacttt cttttaaaac     8880

taagtggaaa tggtatattt ggtgaaacta atgaaagaat cttttgctgg gaaattccat     8940

acagcacccc cagcagcatc ctgtctcagt ctggcgtata attcaacctc ctactgagtg     9000

tccctgtaaa ttatttttaa tatatagcat gagagtgaac tgaggtaagt cattgatgtt     9060

tcccagagat gatgaatgaa caaaagcaaa taggatctgc taaacatttt tattcccaca     9120

gtagtgagca gttttgttct tgttttgata atgttcattt ctgcctaatc ttaggcttca     9180

aatacacctt taagaaagcc caagatgtat tgagtagtag aacttcttat ttgtacacct     9240

gtttataact gcactgccct ggatgttatg gttatttcta aggactgacc tggtaaagct     9300

acttgaactg gtagactgca gggtagaggc agacctagat tcaatgtcta actaagctgc     9360

ttagggctta cattaatttc cacaggtctg ttatccatat catgagttta taagtgttcc     9420

tcccaaagaa aaaatttaaa agtgatggat gaaatataat agtagatgct caataaattc     9480

cattgtattt aaagatt                                                    9497


<210> 3637
<211> 1133
<212> DNA
<213> Homo sapiens

<400> 3637
gagcttcgcg gtgccaccgc cccgcccacg cctcctcgcc ggcctccgag tgcgtcacgt       60

gacgggtcgg tggcgctggc ggttgctgtc agctgattcc cggggttggt ggcagcggcg      120

gtagcagcaa tggactttct cctggggaac ccgttcagct ctccagtggg acagcgcatc      180

gagaaagcca cagatggctc cctgcagagc gaggactggg ccctcaacat ggagatctgc      240

gacatcatca acgagacgga ggaaggtccc aaagatgccc tccgagcagt aaagaagaga      300

atcgtgggga ataagaactt ccacgaggtc ttagaaacct gtgtcaagaa ctgcgggcac      360

cgcttccacg tgctggtggc cagccaggac ttcgtggaga gtgtgctggt gaggaccatc      420

ctgcccaaga acaacccacc caccatcgtg catgacaaag tgctcaacct catccagtcc      480

tgggctgacg cgttccgcag ctcgcccgat ctgacaggtg tggtcaccat ctatgaggac      540

ctgcggagga aaggcctgga gttccccatg actgacctgg acatgctgtc acccatccac      600

acaccccaga ggaccgtgtt caactcagag acacaatcag gacaggattc tgtgggcact      660

gactccagcc agcaagagga ctctggccag catgctgccc ctctgcccgc cccgcccata      720

ctctccggtg acacgcccat agcaccaacc ccggaacaga ttgggaagct gcgcagtgag      780

ctggagatgg tgagtgggaa cgtgagggtg atgtcggaga tgctgacgga gctggtgccc      840

acccaggccg agcccgcaga cctggagctg ctgcaggagc tcaaccgcac gtgccgagcc      900

atgcagcagc gggtcctgga gctcatccct cagatcgcca atgagcagct gacagaggag      960

ctgctcatcg tcaatgacaa tctcaacaat gtgttcctgc gccatgaacg gtttgaacgg     1020

ttccgaacag gccagaccac caaggcccca agtgaggccg agccggcagc tgacctgatc     1080

gacatgggcc ctgacccagc agccaccggc aacctctcat cccagctggc agg            1133


<210> 3638
<211> 6003
<212> DNA
<213> Homo sapiens

<400> 3638
ggctctgtgt atgaatgaca aggatacctt cagccagctc attctggatg aatgaatgat       60

tacactaagt gtcctccaca ttcctctgtg ggctcacttc atggactcac tttgcgtgct      120

tgttaaatgt gctgtgttgc tcccaagacc atgtaaagcc tactgaccac taacctccct      180

cacagcagaa actagacgtc aggttaaaat gggcaactcc gacagtcagt acacccttca      240

aggatctaaa aatcatagca atactattac tggtgctaag caaattcctt gctccctgaa      300

aatacgtggc attcatgcaa aagaggaaaa gtcattgcat ggatggggtc acggaagcaa      360

cggagcaggt tacaagtcca ggtccctggc ccgaagctgc ctttctcact ttaagagtaa      420

ccagccttac gcatcgagac tcggtggccc cacatgcaag gtctccagag gtgttgccta      480

ctccacgcac aggacaaatg ccccagggaa ggatttccag ggcatcagtg ctgctttctc      540

aactgagaat ggcttccact ctgttggcca cgagctggca gataaccaca tcacctccag      600

agactgcaac ggacaccttc tcaactgcta cgggaggaat gagagcattg cctccacccc      660

accgggcgaa gaccgcaaga gcccccgagt gctcatcaaa acgctgggga agctggatgg      720

gtgtttaagg gtcgagttcc acaatggtgg caaccccagc aaagtgcctg cagaggactg      780

cagtgagccg gtgcagctgc tgaggtactc acctacctta gcatcggaaa cctcccctgt      840

gcctgaagcc aggagggggt ccagcgccga ttccctgccc agccatcgcc cctctcccac      900

ggactctcgc ctgcggtcca gcaaaggcag ctccctgagt tctgagtcat cctggtacga      960

ctccccttgg ggcaatgctg gagagctgag cgaggctgag ggctccttcc tggcccccgg     1020

catgcctgac cccagtctcc atgccagctt cccacctggc gatgccaaaa agcctttcaa     1080

ccaaagctct tccctctcct ccctccggga actgtacaaa gatgccaacc tggggagcct     1140

ctccccctca ggtatccgcc tttctgatga atacatgggc acgcatgcca gcctgagcaa     1200

ccgtgtctct tttgcttccg acattgatgt gccctccaga gtggcacacg gggaccccat     1260

ccagtacagt tccttcactc tcccctgtcg gaagcccaaa gcctttgttg aggatactgc     1320

gaagaaggac tccctcaaag ccaggatgcg acggatcagt gactggacgg gaagcctctc     1380

aaggaagaaa aggaaactcc aggagccgag gtccaaggag ggcagtgact actttgacag     1440

tcgctctgat ggactgaata cagatgtgca gggatcctcc caggcatctg cttttctgtg     1500

gtcagggggc tctactcaga tcctgtctca gagaagtgaa tccacacatg cgattggcag     1560

cgatcccctc cggcagaaca tttatgagaa tttcatgcga gagttggaaa tgagcaggac     1620

caacactgag aacatagaaa catctacaga aaccgccgag tccagcagcg agtcactcag     1680

ctctctggaa cagctggatc tgctctttga gaaggaacag ggggtggtcc ggaaggccgg     1740

gtggctcttc ttcaagcccc tggtcactgt gcagaaggaa aggaagcttg agctggtggc     1800

acgaaggaaa tggaaacagt actgggtaac gctgaaagga tgcacgctgc tgttttatga     1860

gacctatggg aagaattcca tggatcagag cagtgcccct cggtgtgctc tgtttgcaga     1920

agacagcata gtgcagtctg ttccagagca tcccaagaaa gaaaatgtgt tctgcctcag     1980

caactccttt ggagatgtct accttttcca ggccaccagc cagacagatc tagaaaactg     2040

ggtcactgct gtacactctg cttgtgcatc cctttttgca aagaagcatg ggaaagagga     2100

cacgctgcgg ctgctgaaga accagaccaa aaacctgctt cagaagatag acatggacag     2160

caagatgaag aagatggcag agctgcagct gtccgtggtg agcgacccaa agaacaggaa     2220

agccatagag aaccagatcc agcaatggga gcagaatctt gagaaatttc acatggatct     2280

gttcaggatg cgctgctatc tggccagcct acaaggtggg gagttaccga acccaaagag     2340

tctccttgca gccgccagcc gcccctccaa gctggccctc ggcaggctgg gcatcttgtc     2400

tgtttcctct ttccatgctc tggtatgttc tagagatgac tctgctctcc ggaaaaggac     2460

actgtcactg acccagcgag ggagaaacaa gaagggaata ttttcttcgt taaaagggct     2520

ggacacactg gccagaaaag gcaaggagaa gagaccttct ataactcagg tcgatgaact     2580

tctgcatata tatggttcaa cagtagacgg tgttccccga gacaatgcat gggaaatcca     2640

gacttatgtc cactttcagg acaatcacgg agttactgta gggatcaagc cagagcacag     2700

agtagaagat attttgactt tggcatgcaa gatgaggcag ttggaaccca gccattatgg     2760

cctacagctt cgaaaattag tagatgacaa tgttgagtat tgcatccctg caccatatga     2820

atatatgcaa caacaggttt atgatgaaat agaagtcttt ccactaaatg tttatgacgt     2880

gcagctcacg aagactggga gtgtgtgtga ctttgggttt gcagttacag cgcaggtgga     2940

tgagcgtcag catctcagcc ggatatttat aagcgacgtt cttcccgatg gcctggcgta     3000

tggggaaggg ctgagaaagg gcaatgagat catgacctta aatggggaag ctgtgtctga     3060

tcttgacctt aagcagatgg aggccctgtt ttctgagaag agcgtcggac tcactctgat     3120

tgcccggcct ccggacacaa aagcaaccct gtgtacatcc tggtcagaca gtgacctgtt     3180

ctccagggac cagaagagtc tgctgccccc tcctaaccag tcccaactgc tggaggaatt     3240

cctggataac tttaaaaaga atacagccaa tgatttcagc aacgtccctg atatcacaac     3300

aggtctgaaa aggagtcaga cagatggcac tctggatcag gtttcccaca gggagaaaat     3360

ggagcagaca ttcaggagtg ctgagcagat cactgcactg tgcaggagtt ttaacgacag     3420

tcaggccaac ggcatggaag gaccgcggga gaatcaggat cctcctccga ggtctctggc     3480

ccgccacctg tctgatgcag accgcctccg caaagtcatc caggagcttg tggacacaga     3540

gaagtcctac gtgaaggatt tgagctgcct ctttgaatta tacttggagc cacttcagaa     3600

tgagaccttt cttacccaag atgagatgga gtcacttttt ggaagtttgc cagagatgct     3660

tgagtttcag aaggtgtttc tggagaccct ggaggatggg atttcagcat catctgactt     3720

taacacccta gaaaccccct cacagtttag aaaattactg ttttcccttg gaggctcttt     3780

cctttattac gcggaccact ttaaactgta cagtggattc tgtgctaacc atatcaaagt     3840

acagaaggtt ctggagcgag ctaaaactga caaagccttc aaggcttttc tggacgcccg     3900

gaaccccacc aagcagcatt cctccacgct ggagtcctac ctcatcaagc cggttcagag     3960

agtgctcaag tacccgctgc tgctcaagga gctggtgtcc ctgacggacc aggagagcga     4020

ggagcactac cacctgacgg aagcactaaa ggcaatggag aaagtagcga gccacatcaa     4080

tgagatgcag aagatctatg aggattatgg gaccgtgttt gaccagctag tagctgagca     4140

gagcggaaca gagaaggagc agcccgaatg gagctcagag gtgatggatg tactagatcc     4200

caggggaaag cttacaaaag gcactctgga agaaccacgg acactggtaa cagaactttc     4260

gatgggagag cttctgatgc actctacggt ttcctggttg aatccatttc tgtctctagg     4320

aaaagctaga aaggaccttg agctcacagt atttgttttt aagagagccg tcatactggt     4380

ttataaagaa aactgcaaac tgaaaaagaa attgccctcg aattcccggc ctgcacacaa     4440

ctctactgac ttggacccat ttaaattccg ctggttgatc cccatctccg cgcttcaagt     4500

cagactgggg aatccagcag ggacagaaaa taattccata tgggaactga tccatacgaa     4560

gtcagaaata gaaggacggc cagaaaccat ctttcagttg tgttgcagtg acagtgaaag     4620

caaaaccaac attgttaagg tgattcgttc tattctgagg gagaacttca ggcgtcacat     4680

aaagtgtgaa ttaccactgg agaaaacgtg taaggatcgc ctggtacctc ttaagaaccg     4740

agttcctgtt tcggccaaat tagcttcatc caggtcttta aaagtcctga agaattcctc     4800

cagcaacgag tggaccggtg agactggcaa gggaaccttg ctggactctg acgagggcag     4860

cttgagcagc ggcacccaga gcagcggctg ccccacggct gagggcaggc aggactccaa     4920

gagcacttct cccgggaaat acccacaccc cggcttggca gattttgccg acaatctcat     4980

caaagagagt gacatcctga gcgatgaaga tgatgaccac cgtcagactg tgaagcaggg     5040

cagccctact aaagacatcg aaattcagtt ccagagactg aggatttccg aggacccaga     5100

cgttcacccc gaggctgagc agcagcctgg cccggagtcg ggtgagggtc agaaaggagg     5160

agagcagccc aaactggtcc gggggcactt ctgccccatt aaacgaaaag ccaacagcac     5220

caagagggac agaggaactt tgctcaaggc gcagatccgt caccagtccc ttgacagtca     5280

gtctgaaaat gccaccatcg acctaaattc tgttctagag cgagaattca gtgtccagag     5340

tttaacatct gttgtcagtg aggagtgttt ttatgaaaca gagagccacg gaaaatcata     5400

gtatgattca atccagatat gggttaaatt cctcatttta cttttaaact ggtggtaaag     5460

tggaaattgc aaaaaaaaaa aaaaaaaaaa actgttcatt cctgggtttt gtgcagtata     5520

cattttccca caaaatggtt gtaaagattt aagttatttt aatttattgt ggatcagaaa     5580

cctagatgaa actggtcaga atctgtaaat tacttagttt atatccactt tgagcaggta     5640

tcaaatgatt taggatcctt aaaattacat tctaataatt aagttatgtg gaaaaagtaa     5700

ggctggggaa gtcgtgatta atagttttca aagggccatt ttttaaaatc ctctgggcat     5760

tttctttcag ctgtttgtta gtttttgctt tatttaaagc atatttaagt tattttaatg     5820

tggtttaggg gcaaaatgtg cagatacttc atttttgtaa gatagattgt aatagatgct     5880

gtttatacta aacatgtcat aactatctat acagtatata ttaaaagaaa gcttgtactg     5940

tatcttattt gatgatattt attttctctg ccaagctgta tagtaaaagg aaaataagtc     6000

aca                                                                   6003


<210> 3639
<211> 357
<212> DNA
<213> Homo sapiens

<400> 3639
cctgcattta gatggctccc gcaaagaagg gtggcgagaa gaaaaagggc cgttctgcca       60

tcaacgaagt ggtaacccga gaatacacca tcaacattca caagcgcatc catggagtgg      120

gcttcaagaa gcgtgcacct cgggcactca aagagattcg gaaatttgcc atgaaggaga      180

tgggaactcc agatgtgcgc attgacacca ggctcaacaa agctgtctgg gccaaaggaa      240

taaggaatgt gccataccga atccgtgtgc ggctgtccag aaaacgtaat gaggatgaag      300

attcaccaaa taagctatat actttggtta cctatgtacc tgttaccact ttcaaaa         357


<210> 3640
<211> 866
<212> DNA
<213> Homo sapiens

<400> 3640
agcgcaccgc gggaagatgg cgttggaggt cggcgatatg gaagatgggc agctttccga       60

ctcggattcc gacatgacgg tcgcacccag cgacaggccg ctgcaattgc caaaagtgct      120

aggtggcgac agtgctatga gggccttcca gaacacggca actgcatgtg caccagtatc      180

acattatcga gctgttgaaa gtgtggattc aagtgaagaa agtttttctg attcagatga      240

tgatagctgt ctttggaaac gcaaacgaca gaaatgtttt aaccctcctc ccaaaccaga      300

gccttttcag tttggccaga gcagtcagaa accacctgtt gctggaggaa agaagattaa      360

caacatatgg ggtgctgtgc tgcagaaact taggaaggaa tctcaagagc atacaaaaga      420

tctagacaag gaactagatg aatatatgca tggtggcaaa aaaatgggat caaaggaaga      480

ggaaaatggg caaggtcatc tcaaaaggaa acgacctgtc aaagacaggc tagggaacag      540

accagaaatg aactataaag gtcgatacga gatcacagcg gaagattctc aagagaaagt      600

ggctgatgaa atttcattca ggttacagga accaaagaaa gacctgatag cccgagtagt      660

gaggaacaaa ttaaggacat tttctacatt gaaaaccaaa aggaatatga aaataaaaaa      720

gctgctagga agaggagaac acaagtgttg gggaaaaaga tgaaacaagc tattaaaagt      780

ctaaattttc aagaagatga tgatacatca cgagaaactt ttgcaagtga cacgaatgag      840

gccttggcct ctcttgatga gtcaca                                           866


<210> 3641
<211> 569
<212> DNA
<213> Homo sapiens

<400> 3641
agctgcgacg ccgagtttca ctctggctgc cttctcctga gagtcggagc cacagccaga       60

gccctgccca ggccgagccg gagctgcagc ccgagcgcgg tggtgccctc agccccgtcc      120

tcttgtcctc ctcagcctcg tccccaggca cagcacacgg atccaacatc tgtacctttg      180

tttttactaa ctgctgtttc ttaatttaaa acctgatcat cttcttcctc gttggcaaag      240

gtgccttgga atttgtgtcg ctgagtcagc aagcctttca gatttgcccg gtttttgttg      300

tttgtggttt gtatcaagat gggaactcaa acaagtcatt cctcctaagg agctggtgtc      360

ttcatccaga agggacagtt tgtgccagct ctccagagag aaaagatctg ccggaggcgc      420

tgggcaatga ccccgggact ccaggccaga ggggtctgaa gctgtttggg aaagcagcgg      480

gactccttgg gaagatggcc atggccccaa gcccttccct ggtgcaggtg tacaccagcc      540

ccgcggctgt ggccgtgtgg gaatggcag                                        569


<210> 3642
<211> 574
<212> DNA
<213> Homo sapiens

<400> 3642
tttttttcct tcagacactt ggattggact taatcttaaa cctctggagt tcaagacctt       60

ttaaaaaggg ctaaataaac aatctctaca tgtaaaaggc cactgactcc tacttcctct      120

gtatagagca actgttgaac tcagctgcct gtagagcgag aataggacag actcgtatac      180

cattctgatc tgggtgcatt tcttcagaag ggcgtgattc tcagtcacca gactcagctt      240

ggagatctta caatgatggc aatcaggaga cactgaacgg agatgctaca tattcctctc      300

ttgcagcaaa aggttttaga agcgttcgac caaacctaca agataaaaga tcaccaactc      360

agagccagat aacagtgaat ggaaactcag gaggtgccgt gagtcccatg agttactatc      420

agaggccgtt ttccccctcg gcatattctc tcccagcctc actcaactcc agcattgtca      480

tgcagcacgg cacatccctc gattccacag acacatatcc ccagcatgcg cagtctctgg      540

atggcaccac cagcagctct atccccctgt accg                                  574


<210> 3643
<211> 691
<212> DNA
<213> Homo sapiens

<400> 3643
gtacgggagc tggaggctga gcttgatgca gagcagaaga agcacgccga ggcccttaag       60

ggcgtgcgca agcatgagcg ccgtgtcaag gagctcgcat accaggccga ggaggacagg      120

aagaacctgg ctcgcatgca ggacctggtg gacaagctgc agagcaaggt caagagctac      180

aagcgccagt ttgaggaggc ggagcagcag gccaacacca acctggccaa gtatcgcaag      240

gcccagcacg agctggatga tgcggaggag cgggcagaca tggcggaaac ccaggccaac      300

aagctgcggg cacggacccg ggacgccctg ggccccaagg tgaggagtgg caggggcatt      360

gctctctgtg cagggggact gtgggggctg acaggtagta ctgctcactc agctatccct      420

ttctcctcag cacaaggagt gacggcctga ccccctgggc tctaaagagg aatgtctgct      480

gttgcacatc tggctgaggc cacctgcccc gatcctgcca tctctgcatc gccccctgct      540

gccttcagcc ttccctgggc cctgaataaa caccacagcc agtttccttc tcattctttt      600

ctttggggtt caggaggaaa aacacagtcc tagggacaaa agccaggtcc acagcagtca      660

tttttaaaat aaagttattt aatagtctcc a                                     691


<210> 3644
<211> 609
<212> DNA
<213> Homo sapiens

<400> 3644
tccaacgtca tggaggctaa tgccgctcgc caggccactc ctgcagagtg gagtcaagat       60

gactccaatg atatgtggga ggaccaggag gaggaagagg aggaggagga ggatggttta      120

gctggccaac ttttatctga cattcttgct acaagtaaat atgaggagga ttactacgag      180

gatgatgagg aagatgaccc tgatgccctg aaggatcctc tctatcagat tgatctgcag      240

gccaccttaa tgacaatgag aggcgagttc tacagaccat cggcatctaa aaaggggagc      300

ctttctacat ttgctccttc tgggccagcc gcaaaccatt ttgcagccct cactggcctt      360

gagatgcact ttcttctcaa cctaaagtgg catcttgacc cttggccctt ggcctcggca      420

gtgacactga tgacaattca gaccaggctc accggtgccg tcacttagga atgctggaac      480

aaaggacatt tctcaaagtt cccctgaaga catgccatct ctagaacctt ttttctcccc      540

gactctaccc ccacctctgt tcctagagcc ctctgctggc gagtccagaa acattattgc      600

ccagaagga                                                              609


<210> 3645
<211> 3250
<212> DNA
<213> Homo sapiens

<400> 3645
gagtcaggaa tggagagaag ggtaatggtt ttacctctta ttgtggaaac ctgttgagat       60

cacagagaat atactgacgg cataaaaggg cagaaccata gcagggtgcg cgctgctgta      120

gttgccttcc atggatctat aggagagcaa gtcctccagg agaagaagtc ctcaccagtg      180

aacggagacc tctctgaact aaggatacca tggccacgtc agccccacta cggagcctgg      240

aagaggaggt gacctgctcc atctgtcttg attacctgcg ggaccctgtg accattgact      300

gtggccacgt cttctgccgc agctgcacca cagacgtccg ccccatctca gggagccgcc      360

ccgtctgccc actctgcaag aagcctttta agaaggagaa catccgaccc gtgtggcaac      420

tggccagcct ggtggagaac attgagcggc tgaaggtgga caagggcagg cagccgggag      480

aggtgacccg ggagcagcag gatgcaaagt tgtgcgagcg acaccgagag aagctgcact      540

actactgtga ggacgacggg aagctgctgt gcgtgatgtg ccgggagtcc cgggagcaca      600

ggccccacac ggccgtcctc atggagaagg ccgcccagcc ccacagggaa aaaatcctga      660

accacctgag taccctaagg agggacagag acaaaattca gggcttccag gcaaagggag      720

aagctgatat cctggccgcg ctgaagaagc tccaggacca gaggcagtac attgtggctg      780

agtttgagca gggtcatcag ttcctgaggg agcgggagga acacctgctg gaacagctgg      840

cgaagctgga gcaggagctc acggagggca gggagaagtt caagagccgg ggcgtcgggg      900

agcttgcccg gctggccctg gtcatctccg aactggaggg caaggcgcag cagccagctg      960

cagagctcat gcaggacacg agagacttcc taaacaggta tccacggaag aagttctggg     1020

ttgggaaacc cattgctcga gtggttaaaa aaaagaccgg agaattctca gataaactcc     1080

tctctctgca acgaggcctg agggaattcc aggggaagct gctgagagac ttggaatata     1140

agacagtgag cgtcaccctg gacccacagt cggccagtgg gtacctgcag ctgtcagagg     1200

actggaagtg cgtgacctac accagcctgt acaagagtgc ctacctgcac ccccagcagt     1260

ttgactgtga gcctggggtg ctaggcagca agggcttcac ctggggcaag gtctactggg     1320

aagtggaagt ggagagggag ggctggtctg aggatgaaga agagggggat gaggaggaag     1380

agggagaaga ggaggaggag gaagaggagg ccggctatgg ggatggatat gacgactggg     1440

aaacggacga agatgaggaa tcgttgggcg atgaagagga agaagaggag gaggaagagg     1500

aggaagttct ggaaagctgc atggtggggg tggctagaga ctctgtgaag aggaagggag     1560

acctctccct gcggccagag gatggcgtgt gggcgctgcg cctctcctcc tccggcatct     1620

gggccaacac cagccccgag gctgagcttt tcccagcact gcggccccgg agagtgggca     1680

tcgccctgga ttatgaaggg ggcaccgtga ctttcaccaa cgcagagtca caggaactca     1740

tctacacctt cactgccacc ttcacccggc gcctggtccc cttcctgtgg ctcaagtggc     1800

caggaacacg cctcctgcta agaccctgag ccctgacatc tgcccccagc cccaaccctc     1860

agatgcttca cttctttgga attccaggac tctcaatggg gggacgggat gcctggccta     1920

agcacctgga gcaggggacc ccatatccac tggtagccac ctccccattg ctgtggcccc     1980

ctgaaatctc actcagtgct gttgctccat ctactgccct aatggggctc ttttcccacc     2040

tcctgctggt ttcccgaggg aacttctgac cctggagtcc atgagggctc ctttcctttt     2100

tgaccacgac cttggcccca gctctgcact ctctggaata agggcccgat gcagcatttt     2160

cttgcccagt gtggcaagac ctcagaaaaa ccagtcaatt acgcctaaga tcattttgct     2220

gtccttaaac cccccaggtt ccttcttgca caaatccact ctgctgccca ccttccctgg     2280

cattttaaac agacctaccc caccccaact cagagttaag catacatggc aatgctgaaa     2340

ataaacaaaa tccactgagg cttcccaggc catttaaagc ctggagtacc agcgcatatc     2400

atctcatggg gtccagagtg gagtccaggc ttctctgaaa ccagggctga gcatatttcc     2460

atagccaagg aggtgggact ccctggagct atctgtggtc ttagggaagg atccagacat     2520

acacggcttt ggggtacaag ctgtgatcac tgatcaataa attatctcta gattggtcct     2580

tgtgagggga gttttaagaa tccagaacat cttgctcttg atcagcacat ccaaaaacac     2640

caagacaaac atccagtgga gcagaacctc tcctgcctcg ggagttctga ccgggttccc     2700

cagcagggtg ttaagcctct gtctctggcc ctaccagcat ccaggttcca ctttcctagg     2760

agagagtgga gatgggaaga cagggaaagg aaggcagcag gaggccacaa gcccaccagg     2820

tcttcatgtc aagagaggga gtaacatgtc ttctcattgc ccacggaccc aacctctgtc     2880

caggtgcccc tcatcatcac agtttaacac aagctcccct gctccagcca aattgatctc     2940

ccagtcttgt ccttacccat tccaagtgct ctgccagccc ctgttcatcc aagttttaag     3000

tcctccaccc tgttctaaga gactgttcca acggctctgg gcctcagtgg tcacttgacc     3060

accattgtct cagagctgcc cactttgtgt gtgtcacatg ctgcctgagt cacatgtaca     3120

tcttatttct gcctctagtt ttgtaagctc ctggagggcg gataacatct tatactactc     3180

ttgtattctc atggcaccta gtgcagtgct gggcacagag taggtgctca ataaagactt     3240

gttgaatgaa                                                            3250


<210> 3646
<211> 2309
<212> DNA
<213> Homo sapiens

<400> 3646
cgcagacggg aagctgctca gcaccggctt cagcaggatg agtgagcggc aactcgcgct       60

ctgggacccg gtaggccagg ccgcgccggg cgcgctagct cgctccttct ctgggtctgc      120

cgggagcgcc ttcccgggct gtggctggcg cccaagaggc cagagcggag cggggagctc      180

ccattcggga aaagcctcgc tgcgactccg gggagccagc agacacccct gctctaggga      240

tcggcctttg agcgcgctta agggttcggg atcggctgag agccgcgtgc ctcctgctct      300

ctccaggccc ggatgctctc caggtcaggg gccagacgtg gccccgcagg aagctgagtg      360

cttaggcccc atttgtctct tccccgcatc cgctcctcca ccccggacac ccaagtcagc      420

aagctggttg ctcatccctc catgctcctc agggcaggca gctgggtgat gtccctccct      480

gtctccccct ccccccagga gaggtttgcg gcccacgagg ggatgaggcc catgcgggcc      540

gtcttcacgc gccagggcca tatcttcacc acgggcttca cccgcatgag ccagcgagag      600

ctgggcctgt gggacccggt aacgcagctg gaggcttggg ttttgctgcg tcgcgtgaag      660

gatcctgcgc tggcgccccc acctggtgat gccgagtccc tgggggtggt ttgctgtgac      720

tgcatgcggc gcgcagcgga acaacttcga ggagccagtg gcactgcagg agatggacac      780

aagcaacggg gtcctattgc ccttttacga tcccgactcc agcatcgtct acctgtgtgg      840

caagggcgac agcagcattc ggtactttga gattaccgac gagccgcctt tcgtgcacta      900

cctgaacacg ttcagcagca aagagccgca gcggggcatg ggtttcatgc ccaaaagggg      960

actggatgtc agcaagtgtg agatcgcccg gttctacaag ctacacgaaa gaaagtgtga     1020

acctatcatc atgactgtgc cccgcaagtc agacctcttc caggacgccg aacccgtgct     1080

catttcgctg agggacggct atgtgccccc caagcaccgc gagctccggg tcacgaagcg     1140

caacatcctg gacgtgcgcc cgccctccgg cccccgccgc agccagtcgg ccagcgacgc     1200

ccccttgtcg cagcacaccc tggagacgct gctggaagag atcaaggccc tccgcgagcg     1260

ggtgcaggcc caggagcagc gcatcacggc tctggagaac atgctgtgcg agctggtgga     1320

cggcacggac tagccccgcg cgccaggcag gcggagcggg gcggggcgca caagctcggc     1380

cccgccccgg cttttagtcc cgaactccgg accccgcctt cttgggctgg gcccgggggc     1440

gggactgggg agggaactcc gcccctcgcg ggagaccaga actcttggag cttaggggag     1500

acccacgtcg ctccagcgga ggctggactg cgagcctcgt ctgggactcg gctggagctg     1560

gcctagggag gcctggggta acctgggggg ctcagcaatg gtgctgcacg gcgaggtggt     1620

gtcccccttt gtcctccgcc cagggcaggg aaagtgctta gtattagcgt gatgcttggg     1680

gttattggag cctgagcttg acctcaaacg ggtggcgatt tgatgggtac ccccaggctg     1740

gggaaaatga cagcgcttct cctaatcagc tcactggatt ccatcaccct gagcggtaaa     1800

ccagatgggc gtcaccccag ttctgcagac acatacacaa cccgtttgct gcagagccgg     1860

acccagtggc tacacccaca gcggtctgtg gtagagaact ctcttccttc tttccaccga     1920

caggggcgag ggctgcttcc tcgcggcagc ccccgcgaag aaatctcgag agaactggca     1980

tgaggagtta ggttcatcac aaatacacac acactgcccc caaccctctg ccgttgcctc     2040

tctcagaaaa acaagacgta ctgaatgaaa tattttacta agcgttcagt ctgtgcctcc     2100

tgcatgggtg ggagtgaggg gaacgagacc cccagcctct gcaaatgcta cccccaggct     2160

cctgggagac ctggcgatgc actcctgggc tcagggtcca tcaggcagcc tcttacccta     2220

gagctctctc cactctgagg ttcagaagga ccccaaccca caccgtaggc gttcccccca     2280

agtaaagtta ggtagcaaaa gcctccggt                                       2309


<210> 3647
<211> 955
<212> DNA
<213> Homo sapiens

<400> 3647
gacggcggtc gcgtcggcgt cagggtcggg gtcggtaagg ggtgcggcaa tgctgcaact       60

gcgggactcg gtggactcgg ccggtacgag ccccacggcg gtgctggcgg ccggcgagga      120

gcccggcagc atcgagcagg cagtggagga gatccgcgtg gtggtgcggc ccgtggagga      180

cggcgagatc cagggagtgt ggctgcttac cgaggtggat cactggaaca atgagaagga      240

gcggctggtg ctggtcacgg agcagtccct gcttatctgt aaatacgact tcatcagtct      300

ccagtgccag caggtggtgc ggatagcgct caacgcagta gacaccattt cctacggaga      360

attccagttt ccccctaaat cgctcaacaa gcgagaaggt tttgggattc gaattcagtg      420

ggacaagcaa agtcgtcctt ccttcataaa cagatggaat ccctggtcta ccaacgtgcc      480

ctatgccact ttcacagaac acccgatggc tggcgcagat gagaagacag catctctgtg      540

tcagttggaa agcttcaagg ctctgttaat ccaagctgtc aaaaaagccc aaaaagaaag      600

ccctttgcca ggacaggcga atggcgtgct gatcctggag cgccccctgc tcatcgagac      660

ctacgtggga ctcatgtcct tcattaacaa cgaggcgaaa ctgggctact ccatgaccag      720

gggcaaaata ggcttttagc cgctgctgct ggaaggatgg ggatctttca cctttaggga      780

tctcagcaca attagaatcg taaagtgaat tctatctatt taattggata ttggactctg      840

ctcatataag ctacagacaa aagccaaaag actctcgctg tccctgtgct gctggtattt      900

cattctctgt aacttcagtt ctggtgtttt ccttgagtat ctacttggct tctcg           955


<210> 3648
<211> 643
<212> DNA
<213> Homo sapiens

<400> 3648
ttaaccactt aacctctcag aactgaacaa agacaacatt gttcctggaa cgccctcttt       60

ttaaaaaagc tttttcccct tcagcattta tccatgagac aatcaccaag atgacccagg      120

gattgtactg cgttgcaggc ttctgccatt tgaccttcct gcctgccagg gttttgagtt      180

catgctgttg tttgtactta aatgagtagc ctgatggact gcagaacata taataaagga      240

gacccctgat gtcctgatgt gtgaagtgtc aagggggtgg aagccgtgca ctgagggaat      300

cctaaaagta agacctacaa gaaaaatcag ctatgaaggc aacataaccc ctactgtaga      360

actaaatgca ctgtgcatga aacttggaaa aaaaccaatg tataagcctg ttgaccctta      420

ctctcggatg cagtccacct ataactacaa catgagagga ggtgcttatc ccccgaggta      480

cttttaccca tttccagttc cacctttact ttatcaagtg gaactttctg tgggaggaca      540

gcaatttaat ggcaaaggaa agacaagaca ggctgcgaaa cacgatgctg ctgccaaagc      600

gttgaggatc ctgcagaatg agcccctgcc agagaggctg gag                        643


<210> 3649
<211> 3275
<212> DNA
<213> Homo sapiens

<400> 3649
agcttgtccc acagcgagct gtggagctgg gagggccatt cagagctctg catggaggca       60

gggtggccgg ccttcgtccc ctcaggccag cagggcaagg cagctcccct caatagagat      120

ccagcaatgg gagcagaatc ttgagaaatt tcacatggat ctgttcagga tgcgctgcta      180

tctggccagc ctacaaggtg gggagttacc gaacccaaag agtctccttg cagccgccag      240

ccgcccctcc aagctggccc tcggcaggct gggcatcttg tctgtttcct ctttccatgc      300

tctggtatgt tctagagatg actctgctct ccggaaaagg acactgtcac tgacccagcg      360

agggagaaac aagaagggaa tattttcttc gttaaaaggg ctggacacac tggccagaaa      420

aggcaaggag aagagacctt ctataactca ggtcgatgaa cttctgcata tatatggttc      480

aacagtagac ggtgttcccc gagacaatgc atgggaaatc cagacttatg tccactttca      540

ggacaatcac ggagttactg tagggatcaa gccagagcac agagtagaag atattttgac      600

tttggcatgc aagatgaggc agttggaacc cagccattat ggcctacagc ttcgaaaatt      660

agtagatgac aatgttgagt attgcatccc tgcaccatat gaatatatgc aacaacaggt      720

ttatgatgaa atagaagtct ttccactaaa tgtttatgac gtgcagctca cgaagactgg      780

gagtgtgtgt gactttgggt ttgcagttac agcgcaggtg gatgagcgtc agcatctcag      840

ccggatattt ataagcgacg ttcttcccga tggcctggcg tatggggaag ggctgagaaa      900

gggcaatgag atcatgacct taaatgggga agctgtgtct gatcttgacc ttaagcagat      960

ggaggccctg ttttctgaga agagcgtcgg actcactctg attgcccggc ctccggacac     1020

aaaagcaacc ctgtgtacat cctggtcaga cagtgacctg ttctccaggg accagaagag     1080

tctgctgccc cctcctaacc agtcccaact gctggaggaa ttcctggata actttaaaaa     1140

gaatacagcc aatgatttca gcaacgtccc tgatatcaca acaggtctga aaaggagtca     1200

gacagatggc actctggatc aggtttccca cagggagaaa atggagcaga cattcaggag     1260

tgctgagcag atcactgcac tgtgcaggag ttttaacgac agtcaggcca acggcatgga     1320

aggaccgcgg gagaatcagg atcctcctcc gaggtctctg gcccgccacc tgtctgatgc     1380

agaccgcctc cgcaaagtca tccaggagct tgtggacaca gagaagtcct acgtgaagga     1440

tttgagctgc ctctttgaat tatacttgga gccacttcag aatgagacct ttcttaccca     1500

agatgagatg gagtcacttt ttggaagttt gccagagatg cttgagtttc agaaggtgtt     1560

tctggagacc ctggaggatg ggatttcagc atcatctgac tttaacaccc tagaaacccc     1620

ctcacagttt agaaaattac tgttttccct tggaggctct ttcctttatt acgcggacca     1680

ctttaaactg tacagtggat tctgtgctaa ccatatcaaa gtacagaagg ttctggagcg     1740

agctaaaact gacaaagcct tcaaggcttt tctggacgcc cggaacccca ccaagcagca     1800

ttcctccacg ctggagtcct acctcatcaa gccggttcag agagtgctca agtacccgct     1860

gctgctcaag gagctggtgt ccctgacgga ccaggagagc gaggagcact accacctgac     1920

ggaagcacta aaggcaatgg agaaagtagc gagccacatc aatgagatgc agaagatcta     1980

tgaggattat gggaccgtgt ttgaccagct agtagctgag cagagcggaa cagagaagga     2040

ggtaacagaa ctttcgatgg gagagcttct gatgcactct acggtttcct ggttgaatcc     2100

atttctgtct ctaggaaaag ctagaaagga ccttgagctc acagtatttg tttttaagag     2160

agccgtcata ctggtttata aagaaaactg caaactgaaa aagaaattgc cctcgaattc     2220

ccggcctgca cacaactcta ctgacttgga cccatttaaa ttccgctggt tgatccccat     2280

ctccgcgctt caagtcagac tggggaatcc agcagggaca gaaaataatt ccatatggga     2340

actgatccat acgaagtcag aaatagaagg acggccagaa accatctttc agttgtgttg     2400

cagtgacagt gaaagcaaaa ccaacattgt taaggtgatt cgttctattc tgagggagaa     2460

cttcaggcgt cacataaagt gtgaattacc actggagaaa acgtgtaagg atcgcctggt     2520

acctcttaag aaccgagttc ctgtttcggc caaattagct tcatccaggt ctttaaaagt     2580

cctgaagaat tcctccagca acgagtggac cggtgagact ggcaagggaa ccttgctgga     2640

ctctgacgag ggcagcttga gcagcggcac ccagagcagc ggctgcccca cggctgaggg     2700

caggcaggac tccaagagca cttctcccgg gaaataccca caccccggct tggcagattt     2760

tgccgacaat ctcatcaaag agagtgacat cctgagcgat gaagatgatg accaccgtca     2820

gactgtgaag cagggcagcc ctactaaaga catcgaaatt cagttccaga gactgaggat     2880

ttccgaggac ccagacgttc accccgaggc tgagcagcag cctggcccgg agtcgggtga     2940

gggtcagaaa ggaggagagc agcccaaact ggtccggggg cacttctgcc ccattaaacg     3000

aaaagccaac agcaccaaga gggacagagg aactttgctc aaggcgcaga tccgtcacca     3060

gtcccttgac agtcagtctg aaaatgccac catcgaccta aattctgttc tagagcgaga     3120

attcagtgtc cagagtttaa catctgttgt cagtgaggag tgtttttatg aaacagagag     3180

ccacggaaaa tcatagtatg attcaatcca gatatgggtt aaattcctca ttttactttt     3240

aaactggtgg taaagtggaa attgcaaaaa aaaaa                                3275


<210> 3650
<211> 1241
<212> DNA
<213> Homo sapiens

<400> 3650
gtcaaagggg cggcccggcc cggcccggaa gctacagcag cggcgcggag actgcggggc       60

gggccatggc ggcgaacctg agccggaacg ggccagcgct gcaagaggcc tacgtgcggg      120

tggtcaccga gaagtccccg accgactggg ctctctttac ctatgaaggc aacagcaatg      180

acatccgcgt ggctggcaca ggggagggtg gcctggagga gatggtggag gagctcaaca      240

gcgggaaggt gatgtacgcc ttctgcagag tgaaggaccc caactctgga ctgcccaaat      300

ttgtcctcat caactggaca ggcgagggcg tgaacgatgt gcggaaggga gcctgtgcca      360

gccacgtcag caccatggcc agcttcctga agggctctgt gtaccagaag accaatgccg      420

tgtctgagat taaaagggtt ggtaaagaca gcttctgggc caaagcagag aaggaggagg      480

agaaccgtcg gctggaggaa aagcggcggg ccgaggaggc acagcggcag ctggagcagg      540

agcgccggga gcgtgagctg cgtgaggctg cacgccggga gcagcgctat caggagcagg      600

gtggcgaggc cagcccccag agcaggacgt gggagcagca gcaagaagtg gtttcaagga      660

accgaaatga gcaggagtct gccgtgcacc cgagggagat tttcaagcag aaggagaggg      720

ccatgtccac cacctccatc tccagtcctc agcctggcaa gctgaggagc cccttcctgc      780

agaagcagct cacccaacca gagacccact ttggcagaga gccagctgct gccatctcaa      840

ggcccagggc agatctccct gctgaggagc cggcgcccag cactcctcca tgtctggtgc      900

aggcagaaga ggaggctgtg tatgaggaac ctccagagca ggagaccttc tacgagcagc      960

ccccactggt gcagcagcaa ggtgctggct ctgagcacat tgaccaccac attcagggcc     1020

aggggctcag tgggcaaggg ctctgtgccc gtgccctgta cgactaccag gcagccgacg     1080

acacagagat ctcctttgac cccgagaacc tcatcacggg catcgaggtg atcgacgaag     1140

gctggtggcg tggctatggg ccggatggcc attttggcat gttccctgcc aactacgtgg     1200

agctcattga gtgaggctga gggcacatct tgcccttccc c                         1241


<210> 3651
<211> 2011
<212> DNA
<213> Homo sapiens

<400> 3651
cttttcctgc ccacgtggtc tcgggctcct gccccgtcct gctcacgagt tcagggctcc       60

tgggcggccg ccttttccag ttccaggtgt gcagaagtgt cctctcccca cgcgcggcgg      120

gctgcacttg gtcgctggct ccgagatcgc gcggggccgc cggaagccca agacggtacc      180

gggggccgca gccgcagccg gcgccgccct ccgccctccc caacagcagg ccgagtcccg      240

tagcatccgg tagggaaatg gtcgtgcttt cggtccccgc cgaagtcacc gtgatcctgt      300

tagatatcga aggtaccaca accccgattg ctttcgtgaa ggacatttta tttccttaca      360

tcgaagaaaa tgttaaagag tatctgcaga cacattggga agaagaggag tgccagcagg      420

atgtcagtct tttgaggaaa caggctgaag aggacgccca cctggatggg gctgttccta      480

tccctgcagc atctgggaat ggagtggatg atctgcaaca gatgatccag gccgtggtag      540

ataatgtgtg ctggcagatg tccctggatc gaaagaccac tgcactcaaa cagctgcagg      600

gccacatgtg gagggcggca ttcacagctg ggcgcatgaa agcagagttc tttgcagatg      660

tagttccagc agtcaggaag tggagagagg ccggaatgaa ggtgtacatc tattcctcag      720

ggagtgtgga ggcacagaaa ctgttattcg ggcattctac ggagggagat attcttgagc      780

ttgttgatgg tcactttgat accaagattg gacacaaagt agagagtgaa agttacaaag      840

attgcagaca gcattgggtg ctcaaccaac aacattttgt ttctgacaga tgttactcga      900

gaggccagtg ctgctgagga agcagatgtg cacgtagctg tggtggtgag accaggcaac      960

gcaggattaa cagatgatga gaagacttac tacagcctca tcacatcctt cagtgaacta     1020

tacctgcctt cctcaaccta gagaagggtt gttaaggcag accgccctgt tccccagagt     1080

tgtccctgta gtgtctaggt ttattctaat ggtaaaagta acttacttaa aaaacatatg     1140

tacacatatg tatgcaagta tgtatatatg tgtatgctca gattaacttc cataggtaca     1200

taagtgaaag aagtctcagt tcagtgaaca caaaacttat ttaaagatgc tttatatgta     1260

gaaattgttt caaatcatac tctaaccctt agtgagggca aagtgtagtt ggtagaagaa     1320

attgctaaat acctatctaa tgtgctatgt ttatcaaatc gtgtactaaa atggaaagct     1380

agttttgaga aattattcag aagccttgtt attttaaaaa tgaaatattt caaagactga     1440

atattttcaa agaaaatgaa taattcattg cccttgtgat ttagaagatt ataacagctg     1500

tatttcatat ttgcctcctt atatatatca aagaccaagg tatttccttc tgcttcaaaa     1560

gaacaaaatt gggaaagaaa actcacttga gtcttgatca aacaagtgtc ttttacttaa     1620

gaagaaactt ggtaatcatt gtggcaccca cagcaagcag ttgccttacc agtgaaaaag     1680

gtgcactgag gtaacatcta aaacagagat gtggttctta atgtttaaca gaacagttct     1740

aatcctgcca cgtgttatca ttatagattt tatagttgcc tttctaacta cttagcacag     1800

tttgagaata cgttaattgc tatttactat ttaaaaagtt ttactgaaat cagtccataa     1860

cattaagatg agccctaata tgtaagattt tcctctggaa tggatgtgag aaatgtaaat     1920

tttataacag cagtatttat cctggtttaa ttctaatacg atgtcatgtt aatttcatgt     1980

tgtgattaat aaaagcattt tttcttcact c                                    2011


<210> 3652
<211> 3549
<212> DNA
<213> Homo sapiens

<400> 3652
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact     1560

catatcaacc caagtaccat gtggacttga tccctggctg aatcacctgg atgacttgga     1620

atagaaatga ctgctttaga agatgggatg gggccgggtg gtaagggata gaagagagga     1680

ctctcaatct actgatcaag tcctttcccc aatgcccagt ggatggccag ggtacctggg     1740

gactcaggct gctgccagtt ctgctcacca ccatccgtgc ttggcacaga agtagctgca     1800

tagaaagagc actggatttg aagtcagaag acctgggttc ttgaaccagc ctgtcaacca     1860

gttgtatgac tttaaacaag gcatctcacc tcttttcatc ttgttttctt ccaataatgt     1920

tagagttcat gtaatcacat tctctagaac catttagttt gtgttaacta tgaaccaagc     1980

agtgtggtgg ccactggtga cttgaaaatg tagagaaaaa aaaaacctgc tctatatctg     2040

aaagagctct tgggaagaca gagaaacata aagaggaaat tatagcacag tgtggtgggt     2100

gttacgggaa gtccaacccc agcattatgg gagttcaggg gaaggggcat agcccagcct     2160

ggaaggagag gatgagtggg ggatggcttt ctgaaaaggg tagtctaaag gatgcctata     2220

gtcaataggg aaaagagggg aagaagcatc ttaagaagag gaaacagcag agaactggct     2280

ggatgacctg tgactctgga gcactgggtt gtctccattg tccttatggg cagatgtgtg     2340

ccatccccag ccgacaccac tcactgcctc cttcctcctg gtgttgccac ttctgggtga     2400

gattaaggtg cagggcctgg gggcaggagg acataaggta tagccataaa tcataaccca     2460

gggaccacac tcaaccctag ggaaattgtc ttcctgatca gttgattacc atctgaggtc     2520

aagaaatgag atagtgggag caaatgggtc acaaatagct cagctgtggg ctcagaaact     2580

gctaggtaaa agaattccag aaggaggcca gggcataagt tggatgacct atgaccttta     2640

gtctaaagaa ttgagactac cgtaattgag actactgtag tgacatctga gaaatgggat     2700

ggaagagtga ccatgtttta ttttcttgtt cttgtcacta ttgtatttta ttttgcataa     2760

tcatgccctt cactgacagt ctccttaaca tcatctgttt actctgctca gatgtaaaat     2820

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca     2880

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt     2940

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta     3000

aagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa     3060

aaaatacaga cacacacaag tgcctatata atgataaaac atatgcaaag cacccaaacc     3120

tgtgattcca gaaaggtaga tcctattttt ctgtttattt ttattggctt tagctgtgtc     3180

ttttgaaagg actattatcc tctaaaatgt atgtgtatga agatcctggc ttgcagctcg     3240

ggagctttac acaccttgtg tcactttatc ttggtaacga gccaagatca tgcaaccagt     3300

tcatccatgt ctgacccaag agctcttaac tgctatgctg cactgcctca ttcagagata     3360

gatgcctgca tgggtcctgg cgattatttt aatgctggct acacccccac aggtgacttg     3420

gattcagaaa tacaatttat atttcttctt tttaaattgt tttattttat ttttctttta     3480

atagttatat gtcagtgaga acaatttata tgtcttacac tgagaaataa aactgctcat     3540

aagtgaaaa                                                             3549


<210> 3653
<211> 4082
<212> DNA
<213> Homo sapiens

<400> 3653
attaggcctg ccgagaggag tgttttcttg catccagaaa agacctgaga ggcggacgac       60

acctgtgctc cgcagagcag aacgtgggag gaacggcggg atgttaaggt aggagctcaa      120

gaagcagaga gtctacctgc ccgacgcgtt cgtggagagg agcagcggtt gctgttggag      180

gaggtgggtg caaggacggc agatggcatc cctgagaggt ggtgactgag actagatgcg      240

ggtgcaggtc tgtttctttc taggttcctg tagagatctg tatgtagctg ttcacttgga      300

agttaattaa gaaagaacaa aaactattca tttggattca aggtccatct ccactggtgg      360

ctgtggtggc tttggattgt tggaagacca tcaccttcag caggtctgca cttgggaaca      420

atcattctcc cccagcccga gcgtgcctct gccctctgta tcattgacag aggctgtatg      480

tttggaaaga gaactttgtg actgcagaac tgacagttga ctctaattct tgctaccaag      540

tttttccccg acccagtgaa agagtgttaa gacttcgacc taggacacat tgagaaccaa      600

ggccaagact ggacagggcc atataactgg gcttcaacca tggctgggac taagaataag      660

acaagagccc aggccaaaac tgaaaaaaag gctgctatac aagctaaagc tggagcagag      720

agggaggcta ctggtgttgt taggcctgta gccaagacca gggccaaagc aaaagccaag      780

acagggtcta agacagatgc agtagcagag atgaaggcag tgtctaagaa caaggttgtt      840

gctgagacga aggaaggagc tctgtcagag cctaagactc tgggcaaagc catgggagat      900

ttcactccca aggctgggaa tgagtccacc agctccacat gtaaaaatga ggctggtact      960

gatgcctggt tctgggctgg ggaagaggcc actatcaatt cctggttctg gaatggagaa     1020

gaggctggta atagtttcag cactaagaat gataaacctg aaattggtgc ccaggtctgt     1080

gctgaggagt tggaacctgc ggctggggcc gattgcaaac ctaggtcagg ggctgaggag     1140

gaggaggaag agaatgttat tgggaactgg ttttgggaag gagatgatac tagttttgac     1200

cctaatccta aacctgtgag caggatagtt aagcctcagc ctgtgtatga aattaatgaa     1260

aaaaataggc ccaaggactg gtctgaggta actatctggc ccaatgcccc tgctgtaact     1320

ccagctgtgt taggatttag atcccaggca ccatctgagg caagccctcc ttcatatatt     1380

gttctggcct ccgctgaaga aaatgcctgt tctttgcctg tggcaacagc ttgccgccct     1440

tctaggaaca ctcgctcatg ctcacagcct atccctgagt gtcgttttga ttctgacccc     1500

tgcatccaga ccatagatga gattagacgt caaatcagga tcagggaggt aaatgggatt     1560

aagccatttg cttgtccttg caaaatggaa tgctatatgg attctgagga atttgaaaaa     1620

cttgttagct tacttaagtc aactactgat cctcttattc ataaaatagc acggattgca     1680

atgggtgtcc ataatgttca cccatttgcc caagagttta ttaacgaagt aggtgtagtg     1740

acacttattg aaagcttgct cagttttcct tcccctgaaa tgagaaaaaa gactgtaatt     1800

actctgaatc ctccttctgg ggatgaaaga caacgcaaaa ttgaattaca tgttaagcat     1860

atgtgtaaag aaaccatgtc atttcctttg aactcaccgg gacagcaatc tggattaaag     1920

atactaggac aactgactac tgattttgtc catcactaca ttgttgccaa ttacttttca     1980

gagcttttcc atttgctgtc ctcaggaaat tgcaaaacca gaaatcttgt tttgaaacta     2040

cttttaaata tgtctgaaaa tccaactgca gccagagaca tgatcaatat gaaggcattg     2100

gcagcattaa aactcatctt taaccagaaa gaggcaaaag ccaatcttgt tagtggtgtg     2160

gccatattta ttaacataaa ggagcatatc agaaaaggct caattgtagt tgttgatcac     2220

ttgagttata atacactcat ggccattttc agggaagtta aagagattat tgaaacaatg     2280

taaaatgagc cagagataga acattttaag ccatcttcaa actctagcag gctgtacatt     2340

acagtgtaca cattatacac tgcatcttta acacagagtc acctgtgaca ggctctaggt     2400

ttgagctaga ctattttggg ggtatcaaat gaatattata ccttgggctg aaaatgtttg     2460

atttttatct tgtctagatt ggcatatttt taacatttta cttaagatag caaaccagtt     2520

cgttttaagt aagctaactt gttcattagt atctgtggct taaaatggca aaaaagaaaa     2580

tatccttgag tttgtaatct agttacagaa gtaaggcata cacacacaca aagataacag     2640

tacctagaga gagagtgtgt gtgagtgtgc gtgtctctgt gtgtgcacgt gcacgctcat     2700

ggccaaatgt gcgcactcta cataaaggag gcaggagttc ctataggcta tttaatgtaa     2760

gagaaactat ttttctcctg ttccagctgt atcagatact cgttccgcaa cacagaaatg     2820

actcagaatc tcagacaaaa tgtattattt gttcaatttt aattttgcta ctacattcat     2880

aactcttaaa ttgttaggct gtttcattta catcaaagtt atctcacaaa agagaaggca     2940

ggaaacgttt tgtgagtgcc tattctatgt caaacactgt gttggcacca tattttacaa     3000

gtttttttcc tcttctcaca gtgatcttgt gagttagtta cttatatttt tattagaact     3060

cattattctg ggtaccctcc aatgagaatt agagaggtta aatacctttt cctagattcc     3120

cacagcagga aggtggcata gctgttttgt ctgacaccag aacccatctc accacactgc     3180

tttacagtct tcctgaagga cattttgagg tgggggggcc ttcaaagctc agagactggt     3240

ttgaatggtt taattttgca atggatcatg tccatgccag gtgttacaat tcttaacttc     3300

ctccaaattc gtgtgtccat tagacatttg gctacatctg gctggaggtc aggagaaaat     3360

tctgaggtaa atagatggat tttatctggc agtgtcgaaa atagtaggag cctaaaactt     3420

tgttcaatga gtaagatgta gatttggagt catcagcagg ggaaacttgt tagatgtcct     3480

ttgtatcttt ttctatccat ttgtattttt tctttcccaa agagctgaaa tcattttata     3540

ccctgaattt aaaaggtaat tgcttttttc ctccttgcga aatcatacct taattttttt     3600

tttttttttt tttaccattt atgatttatt ctcctatgtg tcatatgaaa ggccaagggg     3660

ctttatcttt tactagtagg caagcctggg catttctgca tttgtgccag ctaacactac     3720

aaaatagact taattagaga aatttagacc cagaattgca gcttcaacaa cacaaaacag     3780

gaaagctaga agaggttgct gtgtcaacct acaagatagt gattcttgga agttggtatg     3840

gaccagaaag cattcccagg acatttaggc tatggctgag ttctctaaga ctcagggtgg     3900

gaattataat ccctggtcta agctgatatg aaagtttcta tgtgtgaaaa tatggagtta     3960

tatgctttga gattttctgc cagttaaact aaaacaagat catactgtaa atgtttgtaa     4020

cttgcttccc cccactgtat actgtaaaca tctttgcatg tcaataaata tgcctctaca     4080

ac                                                                    4082


<210> 3654
<211> 2393
<212> DNA
<213> Homo sapiens

<400> 3654
atatctctag gggtttatga caggctgttt tcttttctca gtgtggggat gaattgctcc       60

attatcatct aaattggaag tcatgatgat ggaaaccaac atgtctgaca aaagtgactt      120

aaaagctgag ctagagcgca aaaagcagcg cttagcacag ataagagaag agaagaaacg      180

gaaggaagag gagaggaaaa agaaagaggc tgatatgcag cagaagaaag aacccgttca      240

ggacgactct gatctggatc gcaaacgacg agagacagag gctttgctgc aaagcattgg      300

tatctcaccg gagccgcctc tagtcccaac ccctatgtct ccctcctcga aatcagtgag      360

cactcccagt gaagctggaa gccaagactc aggcgatctg gggccattaa caaggaccct      420

gcagtgggac acagacccct cagtgctcca gctgcagtca gactcagaac ttggaagaag      480

actgcataaa ctgggcgtgt caaaggtcac ccaagtggat ttcctgccaa gggaagtagt      540

gtcctactca aaggagaccc agactcctct tgccacgcat cagtctgaag aggatgagga      600

agatgaggaa atggtggaat ctaaagttgg ccaggactca gaactggaaa atcaggacaa      660

aaaacaggaa gtgaaggaag cccctccaag agagttgaca gaggaagaaa aacagcagat      720

ccttcattca gaggaatttc tcatcttttt tgaccggaca atacgggtaa ttgaaagagc      780

cctggctgaa gattccgaca tcttttttga ctacagcggc cgagagttag aggaaaaaga      840

tggggatgtt caggctggag ccaatctttc tttcaatcgt cagttctatg atgaacattg      900

gtccaagcat cgagtggtca cttgtatgga ctggtccctc cagtaccctg agctgatggt      960

ggcttcttac aacaacaatg aagatgctcc ccatgaacca gatggagtgg ccttggtttg     1020

gaacatgaag tttaagaaaa ccacaccaga atacgtcttc cactgtcagt cctctgtgat     1080

gtcggtctgc ttcgcccgtt tccatcctaa cttggtggtt ggtgggactt actcgggcca     1140

gattgtcctc tgggacaatc gcagtcatcg aaggactcca gtgcagcgga cacccttatc     1200

agctgctgca cacacgcatc ccgtgtactg tgtaaatgtt gttgggaccc agaatgctca     1260

taacctcatc actgtctcca ctgatggcaa aatgtgttcc tggagcctgg acatgctctc     1320

aactccacag gagagcatgg agctggtgta caataagtcc aagcctgtcg ctgttaccgg     1380

aatggctttc ccaacgggag acgtcaataa cttcgtggtt ggcagtgagg aaggtacagt     1440

ctacacggct tgtcgtcatg gaagcaaagc aggtattggt gaggtctttg aaggtcacca     1500

agggccagtg acaggaatta actgccacat ggcagtgggc ccaatcgact tttctcacct     1560

gtttgtcaca tcatcatttg actggactgt caaactgtgg accaccaagc acaacaagcc     1620

gctctactcc tttgaagaca atgcagacta tgtgtacgat gtcatgtggt cccccgtgca     1680

tcctgcgctt tttgcctgcg tggacgggat ggggcgcttg gacctctgga acctcaacaa     1740

tgacaccgag gttccaacag caagtgtggc cattgagggg gcatccgccc taaaccgtgt     1800

tcgttgggcc caagctggca aagaagttgc tgttggggac tcggaaggcc gtatttgggt     1860

ctatgacgtt ggagagcttg cagttcccca caatgatgaa tggacccgat ttgccaggac     1920

ccttgtggaa attcgtgcta acagagctga tagcgaggag gaaggcactg ttgagttatc     1980

tgcctagtgg aaatgagcca cccccactgc agcccccacc tttgtgtcct agagctcagc     2040

gtctgcagtc aagtctcttg tattcggtgt ccattcagta tcagtattgc tgtgatattt     2100

tgggtgccat attgtgccag ctttgctcca agtattctaa atgtgtccca tcatgctttc     2160

cactgaccca aaattcacca cagcatttct atctttatat ttctgtctca aaaatgaaga     2220

gaagggggtt atgggttaag ttgctgcctt ttaactactt tgtagctgta tttaatagct     2280

ggaaacctct ggttaaattt gtgcttacat gcactcctgg catagtccta ttaaatccat     2340

atgaagccag atatgattgg gtgcagatgt ggtgttcctc atattatggt aca            2393


<210> 3655
<211> 776
<212> DNA
<213> Homo sapiens

<400> 3655
tgtcctccca gctaccccct ccctaagcag gctgaggaag aagagatagc aagccctcac       60

ctaacttgac ccctttcttg tctctccccg ctgctagctt ctcccttctc gctgccttgc      120

ggggtgggga aacgtggaag gaattctggg aaaaccagat gtctgggttc tctattcccg      180

tctggcttga ttctggacaa ggggcttcct ctccagggcc tcggtttccc catctttaaa      240

atggactgat agcatagacc tgcccacctt tcagaggtgc ccgaagcctt gacgagataa      300

cagatgagaa gtggttttcg ttgtgatgag ccagctgaag cggttgcacc ggagcgccag      360

accgtcagcg gtgcagtggc tctcgcgtcc ttcacatccc cccacaccca tcccgtggat      420

gatgggggaa ggcactactc ctggggttcc ccgaagcgga tcctgggact gggacctggg      480

gacgcggcca aggaggcggg tttggtgcgg ccactccaag gccaaagcga gaaaatctta      540

ctgcgcacgc gcaatagaca gccgatggag ccaccgatgg agccgtccgg aggggagcaa      600

gagcccggag ccgtcaggtt cctggacctg ccctgggaag acgtgctgct cccacacgtc      660

ctgaaccggg tcccgctgcg ccagctgctc cggctgcagc gcgttagccg ggccttccgg      720

tcgctggtgc agcttcacct ggccgggctg cgtcgcttcg atgccgcgca ggtgag          776


<210> 3656
<211> 1456
<212> DNA
<213> Homo sapiens

<400> 3656
ccggagcggg gatcacctca acttgactgt ggtcccccag ccctccaaga aatgcccata       60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa      120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt      180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt      240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca      300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc      360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc      420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc      480

tcctccatcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc      540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg      600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc      660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg      720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct      780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc      840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc      900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac      960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga     1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg     1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg     1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct     1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc     1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta     1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct     1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat     1440

ataattcccc tctgga                                                     1456


<210> 3657
<211> 555
<212> DNA
<213> Homo sapiens

<400> 3657
cttctctctt cctcggcgct gcctacggag gtggcagcca tctccttctc gctggcgatt       60

ggaagacact ctgcgacagt gttcagtccc tgggcaggaa agcctccttc caggattctt      120

cctcacctgg ggccgcttct tccccaaaag gcatcatggc cgccctcaga ccccttgtga      180

agcccaagat cgtcaaaaag agaaccaaga agttcatccg gcaccagtca gaccgatatg      240

tcaaaattaa gcgtaactgg cggaaaccca gaggcattga caacagggtt cgtagaagat      300

tcaagggcca gatcttgatg cccaacattg gttatggaag caacaaaaaa acaaagcaca      360

tgctgcccag tggcttccgg aagttcctgg tccacaacgt caaggagctg gaagtgctgc      420

tgatgtgcaa caaatcttac tgtgccgaga tcgctcacaa tgtttcctcc aagaaccgca      480

aagccatcgt ggaaagagct gcccaactgg ccatcagagt caccaacccc aatgccaggc      540

tgcgcagtga agaaa                                                       555


<210> 3658
<211> 793
<212> DNA
<213> Homo sapiens

<400> 3658
ggtggcgtcc gggactctcc ctgcaggtga ctgacggcgc cggccgcccc tgcccgtcgc       60

ccgcccgctg ctgccgcccg cccggggtgt ggagcccggc cgctgctcgc gggctgagtg      120

tctgtcgctg ctgccgcctc cacccagcct ccgccatgga cctcttcggg gacctgccgg      180

agcccgagcg ctcgccgcgc ccggctgccg ggaaagaagc tcagaaagga cccctgctct      240

ttgatgacct ccctccggcc agcagtactg actcaggatc agggggacct ttgctttttg      300

atgatctccc acccgctagc agtggcgatt caggttctct tgccacatca atatcccaga      360

tggtaaagac tgaagggaaa ggagcaaaga gaaaaacctc cgaggaagag aagaatggca      420

gtgaagagct tgtggaaaag aaagtttcct cttcggtgat ctttggtctg aagggctatg      480

tggctgagcg gaagggtgag agggaggaga tgcaggatgc ccacgtcatc ctgaacgaca      540

tcaccgagga gtgtaggccc ccatcgtccc tcattactcg ggtttcatat tttgctgttt      600

ttgatggaca tggaggaatt cgagcctcaa aatttgctgc acagaatttg catcaaaact      660

taatcagaaa atttcctaaa ggagatgtaa tcagtgtaga gaaaaccgtg aagagatgcc      720

ttttggacac tttcaagcat actgatgaag agttccttaa acaagcttcc agccagaagc      780

ctgcctggaa aga                                                         793


<210> 3659
<211> 1567
<212> DNA
<213> Homo sapiens

<400> 3659
aggcgcaaga agcaaccagc cgcgctatcc gctcccgttg ctaccggaat gcctcttcag       60

gttagcgatt acagctggca gcagacgaag actgcggtct ttctgtctct gcccctcaaa      120

ggcgtgtgcg tcagagacac ggacgtgttc tgcacggaaa actatctgaa ggtcaacttt      180

cctccatttt tatttgaggc atttctttat gctcccatag acgatgagag cagcaaagca      240

aagattggga atgacaccat tgtcttcacc ttgtataaaa aagaagcggc catgtgggag      300

accctttctg tgacgggtgt tgacaaagag atgatgcaaa gaattagaga aaaatctatt      360

ttacaagcac aagagagagc aaaagaagct acagaagcaa aagctgcagc aaagcgggaa      420

gatcaaaaat acgcactaag tgtcatgatg aagattgaag aagaagagag gaaaaaaata      480

gaagatatga aagaaaatga acggataaaa gccactaaag cattggaagc ctggaaagaa      540

tatcaaagaa aagctgagga gcaaaaaaaa attcagagag aagagaaatt atgtcaaaaa      600

gaaaagcaaa ttaaagaaga aagaaaaaaa ataaaatata agagtcttac tagaaatttg      660

gcatctagaa atcttgctcc aaaagggaga aattcagaaa atatatttac tgagaagtta      720

aaggaagaca gtattcctgc tcctcgctct gttggcagta ttaaaatcaa ctttacccct      780

cgagtattcc caacagctct tcgtgaatca caagtagcag aagaggagga gtggctacac      840

aaacaagctg aggcacgaag agcaatgaat actgacatag ctgaactttg cgatttaaaa      900

gaagaagaaa agaacccaga atggttgaag gataaaggaa acaaattgtt tgcaacggaa      960

aactatttgg cagctatcaa tgcatataat ttagccataa gactaaataa taagatgcca     1020

ctattgtatt tgaaccgggc tgcttgccac ctaaaactaa aaaacttaca caaggctatt     1080

gaagattctt ctaaggccta caggattatg aagcggcact taagattgat ccatccaaca     1140

aaattgtaca aattgatgct gagaagattc ggaatgtaat tcaaggaaca gaactaaaat     1200

cttaatgact attagaagta actaagtatt gttataagtt ttttaaaaac aactggaggc     1260

atctttgtac atattatggc cagttgtaca gaatcgcttt ctgtttagta ctttagttct     1320

gttgagggca aaatattata aatctataga aaataaactg tttgacttga atcatttctg     1380

aataagtaaa tctaaataag aatctatttt aattccttat ttcttcatat taatacatat     1440

gtatactttt ttgtgttact gaattaagct tgcccttgta acaaaatatg ttttggtata     1500

gttaccagga cacttactga ttaattttta acaaggtaga attttaaaat aaaagattta     1560

taaataa                                                               1567


<210> 3660
<211> 2078
<212> DNA
<213> Homo sapiens

<400> 3660
aagccctaga gaggctacca ccggtacacc ccgccttccc acccacgggt aaagtggcgc       60

cgcctacgca ccggcacagc ccctgggctc ccgccccggc gcggagacca ccgtggacat      120

ccgggggcgg gaggccgctc tggccccaag cggagcctct ctctggtaga cgagcccgag      180

ggagcccttc tgggcgcggc gccgcggagc tgctctatgc tccaaccgga agtgctcttc      240

accgccggcc tcccacccag ctctctggtc ccggcggtaa gatggcggct gccgcggagt      300

gcgatgtggt aatggcggcg accgagccgg agctgctcga cgaccaagag gcgaagaggg      360

aagcagagac tttcaaggaa caaggaaatg catactatgc caagaaagat tacaatgaag      420

cttataatta ttatacaaaa gccatagata tgtgtcctaa aaatgctagc tattatggta      480

atcgagcagc caccttgatg atgcttggaa ggttccggga agctcttgga gatgcacaac      540

agtcagtgag gttggatgac agttttgtcc ggggacatct acgagagggc aagtgccacc      600

tctctctggg gaatgccatg gcagcatgtc gcagcttcca gagagcccta gaactggatc      660

ataaaaatgc tcaggcacaa caagagttca agaatgctaa tgcagtcatg gaatatgaga      720

aaatagcaga aacagatttt gagaagcgag attttcggaa ggttgttttc tgcatggacc      780

gtgccctaga atttgcccct gcctgccatc gcttcaaaat cctcaaggca gaatgtttag      840

caatgctggg tcgttatcca gaagcacagt ctgtggctag tgacattcta cgaatggatt      900

ccaccaatgc agatgctctg tatgtacgag gtctttgcct ttattacgaa gattgtattg      960

agaaggcagt tcagtttttc gtacaggctc tcaggatggc tcctgaccac gagaaggcct     1020

gcattgcctg cagaaatgcc aaagcactca aagcaaagaa agaagatggg aataaagcat     1080

ttaaggaagg aaattacaaa ctagcatatg aactgtacac agaagccctg gggatagacc     1140

ccaacaatat aaaaacaaat gctaaactct actgtaatcg gggtacggtt aattccaagc     1200

ttaggaaact agatgatgca atagaagact gcacaaatgc agtgaagctt gatgacactt     1260

acataaaagc ctacttgaga agagctcagt gttacatgga cacagaacag tatgaagaag     1320

cagtacgaga ctatgaaaaa gtataccaga cagagaaaac aaaagaacac aaacagctcc     1380

taaaaaatgc gcagctggaa ctgaagaaga gtaagaggaa agattactac aagattctag     1440

gagtggacaa gaatgcctct gaggacgaga tcaagaaagc ttatcggaaa cgggccttga     1500

tgcaccatcc agatcggcat agtggagcca gtgctgaggt tcagaaggag gaggagaaga     1560

agttcaagga agttggagag gcctttacta tcctctctga tcccaagaaa aagactcgct     1620

atgacagtgg acaggaccta gatgaggagg gcatgaatat gggtgatttt gatccaaaca     1680

atatcttcaa ggcattcttt ggcggtcctg gcggcttcag ctttgaagca tctggtccag     1740

ggaatttctt ttttcaattt ggctaatgaa gggcaaccac ccagaaccca gaaaatgcag     1800

attcactcag tttaatcttg aatgtggaaa cagttcacct cctcccttca tcacgtctcc     1860

gtgtgcttag agcagtttcg ttttctcagt tggatgccct gtgtctctgt gagtggggtg     1920

gagcaaaggg aaccaatgcc gaagaccgag ggcaggggag ggaggcgggg gtggacaggg     1980

aggcagcttg tgaatttttg ttttactgtt taactttatt aaaaaagaaa aaaaaaagag     2040

aataaaatgt tttgaccctt cctggccctt tgctctgg                             2078


<210> 3661
<211> 1669
<212> DNA
<213> Homo sapiens

<400> 3661
aacgaggtct ataacttgac ccaggagttc ttccggcacg ataaaccagt caatgctgaa       60

agtcaaaata gcgtgggggt gttcacccga gaggaggtgc gtaaccgcat caggaatgac      120

cctgacgacc cagaggctac caagcgcctg aagctcgcca tgatccagca gtacctgaag      180

gtggagagct gtgagagcag ctcacacagc atggacgagg tgtccctgag cgccttcggg      240

gagtggaccg agatccccgg cgctcaccac atcatcccct cgggcttcat gcgggttgtg      300

gagctgctgg cggagggcat ccctgcccac gtcatccagc tagggaaacc tgtccgctgc      360

attcactggg accaggcctc agcccgcccc agaggccctg agattgagcc ccggggtgag      420

ggcgaccaca atcacgacac tggggagggt ggccagggtg gagaggagcc ccgggggggc      480

aggtgggatg aggatgagca gtggtcggtg gtggtggagt gcgaggactg tgagctgatc      540

ccggcggacc atgtgattgt gaccgtgtcg ctaggtgtgc taaagaggca gtacaccagt      600

ttcttccggc caggcctgcc cacagagaag gtggctgcca tccaccgcct gggcattggc      660

accaccgaca agatctttct ggaattcgag gagcccttct ggggccctga gtgcaacagc      720

ctacagtttg tgtgggagga cgaagcagag agccacaccc tcacctaccc acctgagctc      780

tggtaccgca agatctgcgg ctttgatgtc ctctacccgc ctgagcgcta cggccatgtg      840

ctgagcggct ggatctgcgg ggaggaggcc ctcgtcatgg agaagtgtga tgacgaggca      900

gtggccgaga tctgcacgga gatgctgcgt cagttcacag ggaaccccaa cattccaaaa      960

cctcggcgaa tcttgcgctc ggcctggggc agcaaccctt acttccgcgg ctcctattca     1020

tacacgcagg tgggctccag cggggcggat gtggagaagc tggccaagcc cctgccgtac     1080

acagagagct caaagacagc gcatggaagc tccacaaagc agcagcctgg tcaccttttc     1140

tcttccaagt gcccagaaca gcccctggat gctaacaggg gcgccgtaaa gcccatgcag     1200

gtgctgtttt ccggtgaggc cacccaccgc aagtactatt ccaccaccca cggtgctctg     1260

ctgtccggcc agcgtgaggc tgcccgcctc attgagatgt accgagacct cttccagcag     1320

gggacctgag ggctgtcctc gctgctgaga agagccacta actcgtgacc tccagcctgc     1380

cccttgctgc cgtgtgctcc tgccttcctg atcctctgta gaaaggattt ttatcttctg     1440

tagagctagc cgccctgact gccttcagac ctggccctgt agcttttctt tttctccagg     1500

ctgggccgtg agcaggtggg ccgttgagtt acctctgtgc tggatcccgt gcccccactt     1560

gcctaccctc tgtcctgcct tgttattgta agtgccttca atactttgca ttttgggata     1620

ataaaaaagg ctccctcccc tgcccctcag cttctctctg gttttctca                 1669


<210> 3662
<211> 573
<212> DNA
<213> Homo sapiens

<400> 3662
agaacagtag caccacccag cagctgggat tctttccctc tctcatttgc ctctctcttg       60

ctttttttcc ttcagacact tggattggac ttaatcttaa acctctggag ttcaagacct      120

tttaaaaagg gctaaataaa caatctctac atgtaaaagg ccactgactc ctacttcctc      180

tgtatagagc aactgttgaa ctcagctgcc tgtaggtaaa cacggtgttc cagaatacag      240

caggagcatc tgggcatttt tgtggctggc gtgattctca gtcaccagac tcagcaaaag      300

gttttagaag cgttcgacca aacctacaag ataaaagatc accaactcag agccagataa      360

cagtgaatgg aaactcagga ggtgccgtga gtcccatgag ttactatcag aggccgtttt      420

ccccctcggc atattctctc ccagcctcac tcaactccag cattgtcatg cagcacggca      480

catccctcga ttccacagac acatatcccc agcatgcgca gtctctggat ggcaccacca      540

gcagctctat ccccctgtac cgatcctcag agg                                   573


<210> 3663
<211> 1472
<212> DNA
<213> Homo sapiens

<400> 3663
atgaagtgtg agcactgcac gcgcaaggaa tgtagtaaga aaacaaaaac tgatgaccaa       60

gagaatgtgt cagccgatgc accgagtcca gcccaggaaa atggagagaa gggagaattc      120

cacaagttgg ctgatgccaa gatatttttg agcgactgcc tggcatgtga cagctgtatg      180

actgcagagg aaggagtcca actttcccag caaaatgcca aggacttctt ccgcgttctg      240

aaccttaaca agaaatgtga tacctcaaag cacaaagtgc tggtagtgtc tgtgtgtcct      300

caatctttgc cttattttgc tgctaaattc aacctcagtg taactgatgc atccagaaga      360

ctctgtggtt tcctcaaaag tcttggctgg gtccgatacg ccgagcgggt gctgggtcgc      420

cccatcactg cccacctctg caccgccaag tccccccagc aggtcatggg ctctttggtg      480

aaggattatt tcgccagaca gcagaacctg tctccagaga agattttcca cgtcattgtg      540

gccccttgtt atgacaagaa gctggaggct cttcaggaaa gccttccccc tgctttgcat      600

ggctcccggg gcgctgactg cgtgttaaca tcaggcacag gctccctgtg ggagtgcaca      660

cctgtaatca cagctactca ggaggctgcg gcaagagaat cacttgaacc cgggaggcag      720

aggttacagc gagacaagat tgcaccactg gactccagcc tgggcggcgg aggtgaaatt      780

gctcaaataa tggagcaagg tgacctctca gtgagagatg ctgccgtcga cactctgttt      840

ggagacttga aggaggacaa agtgacgcgt catgatggag ccagctcaga cgggcacctg      900

gcacacatct tcagacatgc ggccaaggag ctgttcaacg aggatgtgga ggaggtcact      960

taccgagccc tgagaaacaa agacttccaa gaggtcaccc ttgagaagaa cggagaggtg     1020

gtgttacgct ttgctgcagc ctatggcttt cgaaacatcc agaacatgat cctgaagctt     1080

aagaagggca agttcccatt ccactttgtg gaggtcctcg cctgtgctgg aggatgctta     1140

aatggcagag gccaagccca gactccagac ggacatgcgg ataaggccct gctgcggcag     1200

atggaaggca tttacgctga catccctgtg cggcgtccgg agtccagtgc acacgtgcag     1260

gagctgtacc aggagtggct ggaggggatc aactccccca aggcccgaga ggtgctgcat     1320

accacgtacc agagccagga gcgtggcaca cacagcctgg acatcaagtg gtgaagtcag     1380

gccagggcct tccagctgct cttggggcca gagccaagag cctctcagta gagggagggg     1440

ctgccctgag tggagtatta aagacactta ag                                   1472


<210> 3664
<211> 769
<212> DNA
<213> Homo sapiens

<400> 3664
aggggaaggc ccagaggaag atcagtgcca tccacatcct cgatgtcctt gtgctgaatg       60

gcaccgacgt tcgggagcag cactttaacc agcgaattca gcttgccgag aaatttgtga      120

aagccgtttc caagcctagt cggcccgaca tgaatcccat cagggtgaag gaggtgtaca      180

gactggaaga gatggagaag atttttgtca ggttggagat gaagatcatc aagggctcca      240

gtggcacccc aaagctcagc tacacagggc gtgatgaccg gcactttgta cccatgggcc      300

tctacatcgt caggacagtg aatgagccct ggactatggg attcagcaaa agcttcaaga      360

agaagttctt ctacaacaag aaaaccaagg actctacttt tgacctccct gcagactcca      420

ttgccccatt tcacctcccc agccttgcct gcctgtcgaa gatggattaa ctccgcactc      480

ccctgggatc gccacatgac cacttcaagt ccccaagccg cccttcgctg cacagactgc      540

atttttttct gccataatta caagcaatgg cactgactgg agggcatgac agtgtgtggt      600

ggggggatgg acaggtggca caatgtctgc tgctcaaccc cagcagtgcc cgagccctgg      660

aagtaactcc cactatttgg cttggaaagt gcttcccact gtctccttcc cactcgagct      720

gggggccttc tcctctattc tgaattgtaa tccagagctt tcccttgaa                  769


<210> 3665
<211> 3290
<212> DNA
<213> Homo sapiens

<400> 3665
ggagcacaga gaagctccca gctttgaagg tcttgcggtg gtgcgtggcg ggcaggaacc       60

cacaattcca aatacaaacg gtcggcgcga gaagcgcttc tgggcgcagg cgcctggctg      120

tagcgactgg ttgcgggagg ctggactctg gtgactgtaa gcatcaagtg tacctgattt      180

gtgaacctat cttgcttcag ttggtttcct cctaaatatt aggcagatgg gattggctgg      240

tctgtgctct gctaggtgaa aaattagacg atttcaagaa ttggagctga atctgatgtt      300

aagtaatggc aacaggtgac ttaaaaagaa gcttacggaa cctagaacag gtgctccgct      360

tgctaaatta tcctgaagag gtggactgtg taggtttgat aaagggagac ccagcagcat      420

ctttgcccat catcagctat tcttttacct catactcacc ttatgtaaca gaacttataa      480

tggaatccaa tgtagagctc atagcaaaaa atgacttgcg ctttatagat gctgtctata      540

agcttcttcg tgatcaattt aattataaac caattttgac aaaaaagcag tttatccaat      600

gtgggtttgc agaatggaaa atccaaattg tttgtgatat tttgaattgt gtgatgaaaa      660

agcacaagga attaagcagt cttcagaaga ttccatcaca acaaagaaag aaaatcagtt      720

ctggtaagtc agaacctcct ttgggcaatg agaaaatatc tgcagaggct gttggcgttg      780

atatcagtgg caggtttatg acctcaggaa agaagaaagc tgtggtgatt cgtcacttgt      840

ataatgaaga taatgttgac atttctgagg atacattaag tccaataaca gatgttaatg      900

aagcagttga tgtgtctgac ttaaatgcta ctgaaataaa gatgcctgaa gtaaaggttc      960

ctgaaatcaa ggctgagcaa caggatgtaa atgttaatcc tgagattact gcactacaaa     1020

ctatgcttgc tgaatgccaa gaaaatctta agaaactgac ttcgatagag aaaaggttag     1080

actgtttgga acaaaaaatg aaaggaaaag tgatggtaga tgaaaacacc tggactaatc     1140

ttcttagtcg tgtcactctt cttgaaacag aaatgctttt gtctaaaaag aatgatgaat     1200

ttatagagtt taatgaagtt agtgaagact acgcttcttg tagtgacatg gaccttctga     1260

atcctcacag aaaaagcgaa gtagagaggc cagcaagtat tcctctgtcc tctggctata     1320

gtacagcatc atcagattca actcccagag cctctactgt taattactgt ggtttgaatg     1380

agatttcaga gaattttcct gcatggagtg ctacatcctc ttgttccagt ctcagctggc     1440

tgctccgtgg gcatacttca tacctttcat cacagagctt tgcttggcct ctctcctgtg     1500

tgtaatctct gtttcttgga tcctgtgctt accttttcct gctgtactct gatgtttcag     1560

tgaagctcat ccacgaagtc cagaattctg cctggaaacc agcttcctcc tcagctccag     1620

ctcttttaat gggcatatca aaactgatga ctttttcctt cctgctacat gggtaacact     1680

tagttgtttg tctaatttct attttccaga aatttctcaa aatgtctgct gatagcccct     1740

cactcatatt tttcatgtgg gtttatagct ttcatatttc tttattattg taaatggggg     1800

ctgtggaagg tgagaaaaca catgctttct taaaacagaa gctctctcct tcattaattt     1860

aaatattttt atcggctcta gaaaatgcat aaggttagta caagatcagt agagagaaag     1920

tcaaagatta cagaagtgct gaagcagacc attcttcctt tcttcccaat gtctattaag     1980

atcacacata ggtaaactgt tacaaatcca gaatggtgaa agagtccaac aatggctgag     2040

ggaagtagag gttaagatat agctcaacag tgaaagtagc agggaaagag ctgggcaagg     2100

ccaagaccat cttttgtacc gttggtacag taggctaaag gtacggtgtt ccatattaaa     2160

tacagcaata tgaagaaaaa taaattaagt cccttatacc taagacctct atttctctgt     2220

tgattacata cacagtggca atggaaagaa gggaaaataa tggggatagc atttgctcat     2280

tctctgacca tgcaacactg gcagcattct atacttattc tattaactgc atcaaccaca     2340

tcttataaaa cacatttcca taggccatat gtaataggcc ttggctttat tcattgcatt     2400

tattggctcc ttaaattgac aacatataat tgttttcata taattttcat caaataaaat     2460

tcactttaat ttgtatgaac atatttaaag tggaaagtat cttcccaaat ggtccatatc     2520

ttaaagtgtc agatatttta tgggcttcac atctgaactg ccagagatct caggcatagc     2580

atgcattaat cacaaccact tactgacctg gttcagatac ttactcaata catggggcta     2640

gacacagagt gtgccttagg ctaaagaaaa aattattcaa gttgagcata tccataaact     2700

ctggctcaag cagtgtattt tgggggtaat aaacacaagt ttgttcctag ttggagggat     2760

atgatgctta ggtttgaacc tgttaacctt cctgggtttg agggctagaa aacgtggaga     2820

cattcctttc taactaacac attttctaat agaaacaatc caccaggatg ttgagcccac     2880

attttaagag ttcttcggaa tttactgaaa atggaaaact gattacattg ggcacatagg     2940

acatttatat ttatagaaac attttagata agacaagaat tttaaaagcc agaaatcact     3000

tttagtgggc attttcagaa aaatgttgtc aactttttgt aatttttaat aggcataaaa     3060

aagattgtta tattgatatt gacagaaatt aggtggttaa ttagagagcg taaaaggatg     3120

aattgctcta acattggttt agaatttttc tttatatgat tcaattttgt ggtctggcaa     3180

aggcccaata gtcatttatc tagtatgcat acctttccac agctggattt tcaaatatga     3240

tgataaagtt catatgacag acctattctg aaaataaata tgtcagcagg                3290


<210> 3666
<211> 1024
<212> DNA
<213> Homo sapiens

<400> 3666
agtcacagca gccagctgct gtagaagagg ggaggaaaca agccagtgca aggggagcaa       60

aagagaaaag gagccaggct gggcttcctg atcccacagc atcgcagagc tcgggaggca      120

cagctcacag acacaggaaa cacaggactg ctattctgct ctcctgccca cggtgatctg      180

gtgccagctg gtggaacagt gggtgatggc gtccctgctg caagaccagc tgaccactga      240

tcaggacttg ctgctgatgc aggaaggcat gccgatgcgc aaggtgaggt ccaaaagctg      300

gaagaagcta agatacttca gacttcagaa tgacggcatg acagtctggc atgcacggca      360

ggccaggggc agtgccaagc ccagcttctc aatctctgat gtggagacaa tacgtaatgg      420

ccatgattcc gagttgctgc gtagcctggc agaggagctc cccctggagc agggcttcac      480

cattgtcttc catggccgcc gctccaacct ggacctgatg gccaacagtg ttgaggaggc      540

ccagatatgg atgcgagggc tccagctgtt ggtggatctt gtcaccagca tggaccatca      600

ggagcgcctg gaccgatggc tgagcgattg gtttcaacgt ggagacaaaa atcaggatgg      660

taagatgagt ttccaagaag ttcagcggtt attgcaccta atgaatgtgg aaatggacca      720

agaatatgcc ttcagtcttt ttcaggcagc agacacgtcc cagtctggaa ccctggaagg      780

agaagaattc gtacagttct ataaggcatt gactaaacgt gctgaggtgc aggaactgtt      840

tgaaagtttt tcagctgatg ggcagaagct gactctgctg gaatttttgg atttcctcca      900

agaggagcag aaggagagag actgcacctc tgagcttgct ctggaactca ttgaccgcta      960

tgaaccttca gacagtggag cttcggagga agatcctggt gaaggggaag aagttaacac     1020

ttga                                                                  1024


<210> 3667
<211> 671
<212> DNA
<213> Homo sapiens

<400> 3667
gtttgagcag cattgttaga gcctgtggaa aacactttac aactgtgtaa ctgtcttcat       60

ctttacagag gaatagtcta caaaggaaga cttgtaacct ggagaagaga cctgtcattt      120

actccatcct ttatagtgat gctacaggac gaagaggaat ggataaaaac attggcgagc      180

aactcaataa agcgtatgaa gccttccggc aggcatgcat ggatagagat tctgcagtaa      240

aagaattaca gcaaaagact gagaactatg agcagagaat acgtgaacaa caggaacagc      300

tgtcacttca acagactatt attgacaagc taaaatctca gttacttctt gtgaattcca      360

ctcaagataa caattatggc tgtgttcctc tgcttgaaga cagtgaaaca agaaagaata      420

atttgactct tgatcagcca caagataaag tgatttcagg aatagcaaga gaaaaactac      480

caaaggtaga cattgcttct gcagaaagca gcatttaaat gctgatgcgt gacatagctt      540

cctcatttta tttttctgaa gtgatctgct ggaattccaa acagaagttc catatataca      600

aatatgtggc ttaaatattt ctaaatagaa gaactatttt caagtaaaat aaaggctgag      660

gttttgtatt t                                                           671


<210> 3668
<211> 3959
<212> DNA
<213> Homo sapiens

<400> 3668
agacgcagag gcgaggccgc cagtcgagga cgaggaggag ataacatcaa gatgccgaag       60

actgaggaaa ctgtgctcca gaatgatccc agtgtagcag agaatggggc ccctgagcct      120

aaaacaccag ggcagagcca gaaaagcaag agtttctgtt tagatgacca gtctcctgac      180

ctgatgtctt ttctgtcaca gatctgatag agacagttaa tgaagtttcc aagctgagca      240

tttcacatga aattgtagta aaccaagatt tctatgtgga agagaccatt ttgcctccaa      300

acagtgtaga aggcaggttt gcggaggcaa tgtacaatgc tttttggaac catctgaaag      360

aacagctatt gagtactcct cctgacttca cttgtgccct tgaacttcta aaagatgtta      420

aggagacctt gctatcactg ctattaccat ggcagaaccg cctaagaaat gagatagaag      480

aagctctgga cacagatctc ctcaagcagg aagcagaaca tggggccctg gatgtccctc      540

atctttctaa ctacattctc aatttgatgg ctctgctatg tgcaccggtt cgagatgaag      600

cgatacagaa actagagacc ataagagatc cagtgcagtt actgaggggc atcctccgtg      660

ttctgggcct aatgaaaatg gacatggtga actataccat ccagagcttt cgaccctacc      720

tgcaggaaca ttccatccag tatgaacaag ctaaattcca ggaactcctt gataaacagc      780

ccagtctcct cgattatacc acaaaatggc taaccaaagc agccacagac atcactacac      840

tatgtccgag ttctcctgac tcacctagct cctcctgcag catggcgtgt tcacttccaa      900

gcggggcagg taacaattca gagcccccca gtccaacaat ggtgctatac caaggctacc      960

tgaacctcct cctctgggat cttgaaaacg tagaattccc agagactctg ctgatggaca     1020

gaatccggct ccaggaactg gcattccagt tgcaccagtt aactgtcctg gcctcagtct     1080

tgctagtggc cagaagcttc tctggtgaag ttttattcag atcacctgaa tttgtggata     1140

gactgaaatg caccaccaag gccctaactg aggaatttat ctccaggcct gaagagacta     1200

tgctgagtgt gagtgaacag gtgtctcagg aagtccatca aggccttaag gacatgggcc     1260

tcactactct gagcagtgaa aacacagcat ctcttctagg ccaactccag aacatcacca     1320

agaaagagaa ctgcattcgt agcattgttg gagtctctgc tacactttcc tggaggcctc     1380

attctcattg aaaaggagtt ggcagaactg ggctggaagt ttctcaatct gatgcatcat     1440

aatcagcaga gtcatttttc acaaaacgaa atctttccag aagatcacga ataagagaga     1500

tcaaagctag gcagcttgag ttgaagtaga gctggaagaa ggagttttga ggactgtttc     1560

aaaaccactg gactagatga tctctaaagt ggtgacatgg acataggata atggttatag     1620

acagtccccc tcccaacggg aaaaaatgaa agcaagcaaa aagttaccag ctccaagcca     1680

acttgaaatc caatcaggat cttatccagg acgcttcatt gcatttggtc ttcatttctc     1740

cttagtctcc tccaggctga catttcctca atctttattg gtcttccaca gccctgacac     1800

ttttggagat accagtcagc atttccaagt tcgttctgtg agactgtagt gtcaggacaa     1860

agcaacaaca aaatgtgctc tactctaaag aagtgtggga catacagaac tgaagttgca     1920

gaatgccatg accatggtag cacttttcaa ggaagaaaga aaggtgggag ttctttccgg     1980

gataattttg acaagaggag ctgtcattat gaacatggtg ggtatgagcg cccgccttca     2040

cactgccagg agaatgatgg aagcgtggag atgagggatg tccacaagga ccaacaacta     2100

agacacactc cttatagcat ccgatgcgaa agaagaatga aatggcatag tgaagacgaa     2160

atccgtatta ccacgtggag aaatagaaaa cctccggaga gaaaaatgag tcagaacaca     2220

caggatggat acacaaggaa ctggtttaag gtcacaattc cttacgggat aaagtatgac     2280

aaggcatggc taatgaattc aatccagagc cattgcagtg accgcttcac tccggttgat     2340

ttccactacg tccgaaatcg ggcatgcttc tttgtccagg atgctagcgc tgcctccgca     2400

ttgaaggatg tcagttataa gatttatgat gatgagaacc aaaagatatg tatatttgtc     2460

aatcattcta ctgcgcccta ctctgtgaag aataagttga agccaggcca aatggagatg     2520

ctaaagctga ccatgaacaa acggtacaat gtctcccagc aagctcttga tctccagaat     2580

ctccgctttg acccagactt gatgggccgt gacattgata taatcctgaa tcgaagaaac     2640

tgcatggctg ccaccctgaa gatcattgaa agaaatttcc ctgagctgtt gtctttgaac     2700

ttgtgcaaca acaagctgta ccagctggat ggcctttctg acattacaga gaaggctccc     2760

aaagtcaaga ccctgaatct ctccaaaaat aagctggagt cggcgtggga gttgggcaag     2820

gtgaaagggc tgaagctcga agagctatgg ctagaaggga acccgttgtg cagcaccttc     2880

tcggaccagt ccgcctatgt aagtgccatc cgggattgtt tccccaagtt gttacgcctg     2940

gacggccgag agttatccgc accagtgatt gttgacattg acagctctga gacaatgaaa     3000

ccctgcaagg aaaactttac tggatctgag accctaaagc atttagtcct gcaattcctg     3060

cagcagtatt actcgatcta tgactctgga gatcgacagg gtctcctcgg tgcttaccac     3120

gatgaggcct gcttctcctt ggctattccc ttcgacccca aggactcagc cccgagcagc     3180

ttgtgcaagt actttgagga tagcaggaat atgaaaacac tcaaggaccc ctacctgaag     3240

ggggaactgc tgaggcgcac aaaacgtgac attgtggact ccctcagtgc gttgcccaaa     3300

actcagcatg acctcagctc catcctggtg gacgtgtggt gccagacgga aaggatgctc     3360

tgcttttctg tcaatggggt tttcaaggaa gtggaaggac agtctcaggg ttctgttctc     3420

gccttcaccc ggaccttcat tgctacccct ggcagcagtt ccagtctgtg catcgtgaat     3480

gacgagctgt ttgtgaggga tgccagcccc caagagactc agagtgcctt ctccatccca     3540

gtgtccacac tctcctccag ctctgagccc tccctctccc aggagcagca ggaaatggtg     3600

caggctttct ctgcccagtc tgggatgaaa ctggagtggt ctcagaagtg ccttcaggac     3660

aatgagtgga actacactag agctggccag gccttcacta tgctccagac cgagggcaag     3720

atccccgcgg aggccttcaa gcaaatctcc taaaaggagc cctccgatgt cttctttgtc     3780

ttcgttcaca tcctctttgt ttcctctttt caccagccta aggcctggct gaccaggaag     3840

ccaacgttaa cttgcaggcc acgtgacata accacccaaa gagccagttg ctctgtgtat     3900

tcgccccact catgatcacc attttatttt cataataaag agtgacgtta cacgttgta      3959


<210> 3669
<211> 633
<212> DNA
<213> Homo sapiens

<400> 3669
gagtttcact ctggctgcct tctcctgaga gtcggagcca cagccagagc cctgcccagg       60

ccgagccgga gctgcagccc gagcgcggtg gtgccctcag ccccgtcctc ttgtcctcct      120

cagcctcggt gccttggaat ttgtgtcgct gagtcagcaa gcctttcaga tttgcccggt      180

ttttgttgtt tgtggtttgt atcaagatgg gaactcaaac aagtcattcc tcctaaggag      240

ctggtgtctt catccagaag ggacagtttg tgccagctct ccagagagaa aagaaacttc      300

caattgaaga cactgagctg aaccattccg cccgcccgcc cgcccgaggg cactccagat      360

ctgccggagg cgctgggcaa tgaccccggg actccaggcc agaggggtct gaagctgttt      420

gggaaagcag cgggactcct tgggaagatg gccatggccc caagcccttc cctggtgcag      480

gtgtacacca gccccgcggc tgtggccgtg tgggaatggc aggacgggct gggcacctgg      540

cacccctaca gtgccaccgt ctgcagcttc atcgagcagc agtttgtcca gcagaagggc      600

caacgttttg ggcttgggag cctggcccac agc                                   633


<210> 3670
<211> 269
<212> DNA
<213> Homo sapiens

<400> 3670
ctcaaccaca gactacactt gctgaactgg ctcctggggc catgaggctg tcactgccac       60

tgctgctgct gctgctggga gcctgggcca tcccaggggg cctcggggac agggcgccac      120

tcacagccac agccccacaa ctggatgatg aggagatgta ctcagcccac atgcccgctc      180

acctgcgctg tgatgcctgc agagctgtgg cttaccagag actctgctcc tatcctcccc      240

acctccccct aactgagcag cagtcctga                                        269


<210> 3671
<211> 2954
<212> DNA
<213> Homo sapiens

<400> 3671
gggtgacgca ggcgcagcgc gggctgcgcg cgctactgcc catccccggt tgtcccactt       60

ttgttcgcct ctcttcggcc ctctactcaa gagctccgtc tccgtctcgc cctcctcgaa      120

gtcctcgtcg cgcgcccgcg acccaggtcg ccctgaaatc tagcccgtcc gagcgcgagt      180

ccaacgccgc ggccgcacca aggccccctc agaccgtgcc atgggtgaca gtgatgacga      240

gtacgatcga aggcgcaggg acaagttcag aagagagcgc agcgactacg accgttcccg      300

cgagagagat gaaagacgtc gaggggacga ttggaatgac agagagtggg accgtggccg      360

tgagcgccgt agtcggggtg aatatcggga ctatgaccgg aatcggcgag agcgcttctc      420

gccacctcgc cacgaactca gcccgccaca gaagcgcatg aggagagact gggatgagca      480

cagctctgac ccataccaca gtggctatga gatgccctat gctggggggg gtgggggccc      540

aacttatggc ccccctcagc cctggggcca ccctgacgtc cacatcatgc agcaccatgt      600

cctgcctatc caggccaggc tgggcagcat tgcagagatt gacctgggtg tgccgccgcc      660

cgtgatgaag accttcaagg agtttctcct ctccctggat gactcggtgg atgagacgga      720

ggccgtcaag cgctataatg actacaagct ggatttccgg aggcaacaga tgcaggattt      780

cttcctggcg cacaaagatg aggagtggtt tcggtctaag taccacccag atgaggtggg      840

gaagcgtcgg caggaggccc ggggggccct gcaaaaccga ctgagggtct tcctgtccct      900

catggagact ggctggtttg ataaccttct cctggacata gacaaagctg atgccattgt      960

caagatgctg gatgcagccg tgattaagat ggaaggaggc acggagaatg atcttcgcat     1020

cctggagcag gaggaggagg aggagcaggc aggaaagcct ggggagccca gcaagaaaga     1080

agaaggacgg gctggagcag gcctagggga cggggagcgc aaaaccaacg acaaggatga     1140

gaagaaggaa gacggcaagc aggctgagaa tgacagttct aatgatgaca aaacaaagaa     1200

gtcggagggt gatggggaca aggaagagaa gaaagaagac tccgagaagg aagccaaaaa     1260

gagtagcaag aagcggaacc ggaagcacag tggtgacgac agctttgacg agggcagcgt     1320

gtcagagtct gagtcggagt cagagagcgg ccaggctgag gaggagaagg aggaggccga     1380

agaagcgctc aaggagaagg agaagcccaa ggaagaagaa tgggagaagc ccaaggacgc     1440

cgcggggctg gagtgcaagc cgcggccgct gcataagacc tgctccctct tcatgcgcaa     1500

catcgcgccc aacatctccc gggccgagat catctccctt tgtaaaaggt acccaggctt     1560

tatgcgggtg gcgctctcag agccccagcc agagaggagg tttttccgtc gtggctgggt     1620

gaccttcgac cgcagtgtta acattaaaga gatctgttgg aacctgcaga acatccgtct     1680

ccgggagtgt gagctgagcc ctggtgtgaa cagggacctg acccggcgcg ttcgcaacat     1740

caacggcatc acccagcaca agcagattgt gcgcaacgac atcaagctgg cggccaagct     1800

gatccacacg ctggatgaca ggacacagct ttgggcctca gaaccaggga cgcctcccct     1860

gcccacgagc ctgccctcgc aaaacccgat cttgaagaat atcaccgact acctgatcga     1920

ggaagtaagc gccgaggagg aggagctgct ggggagcagc gggggcgctc ctcctgagga     1980

gcctcctaag gaagggaacc cggcagagat caacgtggag cgggatgaga agttgattaa     2040

ggtcttggac aagctcctcc tttacctgcg catcgtgcat tccttggatt attacaacac     2100

ctgtgagtac cccaacgagg acgagatgcc caatcgctgt gggatcatcc acgttcgggg     2160

gcccatgcca cccaaccgca tcagtcacgg ggaagtgctg gagtggcaga agacttttga     2220

ggagaagctc acgccgttgc tgagtgtgcg ggagtcactc tcagaggaag aggcccagaa     2280

gatggggcgc aaagacccag agcaggaagt ggagaagttc gtcacctcca acacgcagga     2340

actgggcaag gataagtggc tgtgtcctct cagtggcaag aaattcaagg gtcctgagtt     2400

tgtgcgcaaa catatcttca acaagcatgc agagaaaatt gaggaagtga aaaaggaagt     2460

cgcgtttttt aacaacttcc tcactgatgc taagcgccca gctctgcctg agatcaagcc     2520

agcccagcca cctggccccg cccagagttt gaccccagga ctcccctacc cacaccagac     2580

tccccagggc ctgatgccct atggtcagcc ccggcccccg atcttgggct atggagctgg     2640

tgctgtccgc cctgcagtcc ccacaggagg ccctccatac ccccatgccc cgtatggtgc     2700

tggtcgaggg aactatgatg ccttccgagg ccagggaggt tatcctggga aacctcgcaa     2760

caggatggtt cgtggagacc caagggccat tgtggaatat cgggacctgg atgccccaga     2820

cgatgttgat ttcttttgag ccgtcccccg ttcctcagtc ctgtatcatc catacttgta     2880

ctaccttgtc ctatgaagct ctgagaattt tttgtacgat cagccttact gctaataaaa     2940

gcacttccac aggg                                                       2954


<210> 3672
<211> 1321
<212> DNA
<213> Homo sapiens

<400> 3672
cccagaagat gtccaggctt tggtgagcgg gaagcttgca cttcggtatg cagggaggca       60

gacagaagca ttaaaatgcg tggctcaggc tagcaagaac agatcactgg cagattttga      120

aaaggctctg acagattacc gggcagagct ccgggatgac ccaatcatca gcacacactt      180

ggccaagttg tatgataact tactagaaca gaatctgatc cgagtcattg agcctttttc      240

cagagtacag attgaacaca tatctagtct catcaaactc tccaaggccg acgtggaaag      300

gaaattatca cagatgattc ttgacaagaa atttcatggg attttggacc agggggaggg      360

tgtcctgatt attttcgatg aacccccagt agataaaact tacgaagctg ctctggaaac      420

aattcagaac atgagcaaag tagtggattc cctctacaac aaagccaaga aactgacata      480

ggtgagtgct ggcttcagga ccccagggct gggcagctct gtcttctgcg tgtcgagact      540

gaaaacctcc tcctggtgtc ctcatggctt cctgattgac actgctctgt cttctcttgc      600

agagttggat ctgtagcggt cctttggaga gtgtgtgtgg cgggagagtg aaaccttggg      660

ggaaaatgct aggagattct tttttctttt tgttctactt ttcgctcgga aagtttttaa      720

atcctcattt ggtgcatctg tattccagcc aataggtgtg ccagttttca tgtaatcttt      780

actggcccaa cttgggagtg gggaaattgc ttaaaaaaaa agaaaaagaa aaaaaaaaag      840

attattctaa ataaaaggaa aaaggcttac actacctaaa gctgtgctct ctgcctcctg      900

ggagagggcc gcaaagccag gcaccccgcc aaccactggg ggtcctaatc cacctgctgg      960

gcatcacctc tcctcctcct cagaattggg tgtttgctga ccatcaaaag caatgacttt     1020

ttattctgtt tgtactgaac caaaacaaac aactgtgtat agactgctgt tttctttttt     1080

atttgaaatg aggcattttg gtgttctttc ccctaccata cggcctgtct gcccttccct     1140

ccccacattg gctccagcag agtagccgaa ggtcctgccg ccgccgccac caccaccacc     1200

actgcagcaa caacagcagc agcagcagca gcgcctgcat agctccactc tgacctgtga     1260

aggaatgggg atgaggccag gagctagtgt ctaccacggc cacacaggga gcagtgtggg     1320

c                                                                     1321


<210> 3673
<211> 4815
<212> DNA
<213> Homo sapiens

<400> 3673
cttttctctc gaagggcacc cgaagattgt cacgagtcct tagactccaa ctactgcggc       60

agcttccaaa tttcctgaaa accctaagct gggccagccc ggcagcccac gcacttccgg      120

cctcggaccc gccccaaaca cccaagcgcc ccagcgcctc atctctaggt ccggaaataa      180

acgaacatct ccgattatgg ttataccagg gtcgagggtt tccgaatata ttcgattcaa      240

agcttcggca agacgaagaa aaccgagcct gaaagcaggg cgagaaaagg ggcgctgcag      300

ggcggatgga aagaattgat tggtaacgat gtggagacgg aaacatccga ggacatccgg      360

aggaacccgg ggagttctga gtggtaatcg aggggtagag tatggcagtg ggcggggtca      420

tctcggtacg ttcgaagggc gttggcggaa attaccgaag atgcccgaag ccgtcgggac      480

ggacccgagt acctcacgca agatggcgga gctggaggag gtgactctgg acgggaagcc      540

tcttcaggcg ctgcgggtga ccgacctgaa ggccgcactg gagcagcgag gcctagccaa      600

gagcgggcag aagagtgccc tggtcaagcg gctcaaaggg gctctaatgc tagaaaattt      660

acagaaacac tcaacacccc atgctgcatt ccagccaaat tcccagattg gtgaggaaat      720

gagccagaac agtttcataa aacagtatct ggaaaagcag caggagctac ttaggcagcg      780

tctggaacgt gaagctcgag aagctgcaga acttgaagga aaaagctcct caatttctga      840

agagaaaggt gactctgatg atgagaaacc aaggaaagga gaaagacgat catctagggt      900

cagacaggca agagcagcta aactgtctga gggcagccaa cctgctgagg aggaagagga      960

tcaagaaaca ccttccagaa acctaagggt cagagcagat cgaaatttga aaacagagga     1020

ggaagaagag gaggaggagg aggaggaaga agatgatgaa gaagaggaag gtgatgatga     1080

gggacaaaaa tctagggagg caccaatcct gaaagagttt aaggaagaag gggaagagat     1140

acctagagta aaaccagagg agatgatgga tgagagaccc aaaacaagat cccaggaaca     1200

ggaggtgtta gagagaggag ggagatttac aagatcccag gaagaggcta gaaaaagtca     1260

tctggccaga cagcagcagg agaaggaaat gaaaacaaca tctccccttg aggaggaaga     1320

aagagaaata aaatcttcac aaggcttaaa ggaaaaatcg aagtctcctt cccctcctcg     1380

actgactgaa gatcgaaaga aggcctcact tgtagcgctg ccagagcaaa ctgccagcga     1440

ggaggagact cctccacctt tactaacaaa ggaagcatct tctccaccac ctcatccaca     1500

gctccatagc gaagaagaaa tagagcccat ggaaggccca gcccccgctg tcctcattca     1560

gttatctcct cctaatacag atgctgacac cagggagcta ttagtatctc agcatactgt     1620

ccagttggta ggaggcctgt ctcctttgtc aagtccttca gacaccaaag cagaatctcc     1680

agcagagaaa gtgccagagg agagtgtcct gcctctggtt cagaaaagca cactggctga     1740

ctactcagcc cagaaggatc ttgaacctga gtcagacaga tctgctcagc ccctccctct     1800

aaaaattgag gaattagcac tggccaaagg aatcactgaa gaatgtctga aacagccatc     1860

tttggaacag aaggaaggca gaagagcttc tcataccctt ctcccaagcc acagattgaa     1920

acagtcagct gattcatcct ctagccggtc ctcctcatct tcctcctcca gttctagatc     1980

aagatctcgc tctcctgaca gttcaggttc tcggtctcat tcaccgctca gatccaagca     2040

gagagatgta gcccaggcac gtactcatgc caaccctcgt ggtagaccca agatgggctc     2100

cagatcaaca tcagagtcca gatcaaggtc acgttcacgt tctcgttcag catcaagcaa     2160

cagcagaaaa tctctgagcc ctggagtctc cagggacagc agcaccagct atactgaaac     2220

caaagatccc tcttctggtc aggaggttgc aactccacca gtgccacaac tgcaggtctg     2280

tgagccaaag gagaggactt ccacctcctc atcctctgtc caagcaaggc gtctgagtca     2340

gcctgaatca gctgaaaagc atgtgaccca gaggttacag cctgagcggg ggagcccaaa     2400

gaagtgtgaa gctgaagagg cagagccacc agctgccaca cagccccaaa cctcagagac     2460

tcagacctct catctgccag aatcagaaag aattcatcac actgttgagg agaaggagga     2520

agtgaccatg gacacaagtg aaaacagacc tgaaaatgat gttccagaac ctcccatgcc     2580

tattgcagac caagtcagca atgatgaccg cccggagggc agtgttgaag atgaggagaa     2640

gaaagagagc tcgctgccca aatcattcaa gaggaagatc tccgttgtct cagctaccaa     2700

gggggtgcca gctggaaaca gtgacacaga ggggggccag cctggtcgga aacgacgctg     2760

gggagccagc acagccacca cacagaagaa accttccatc agtatcacca ctgaatcact     2820

aaagagcctc atccccgaca tcaaacccct ggcggggcag gaggctgttg tggatcttca     2880

tgctgatgac tctcgcatct ctgaggatga gacagagcgt aatggcgatg atgggaccca     2940

tgacaagggg ctgaaaatat gccggacagt cactcaggta gtacctgcag agggccagga     3000

gaatgggcag agggaagaag aggaagaaga gaaggaacct gaagcagaac ctcctgtacc     3060

tccccaggtg tcagtagagg tggccttgcc cccacctgca gagcatgaag taaagaaagt     3120

gactttagga gataccttaa ctcgacgttc cattagccag cagaagtccg gagtttccat     3180

taccattgat gacccagtcc gaactgccca ggtgccctcc ccaccccggg gcaagattag     3240

caacattgtc catatctcca atttggtccg tcctttcact ttaggccagc taaaggagtt     3300

gttggggcgc acaggaacct tggtggaaga ggccttctgg attgacaaga tcaaatctca     3360

ttgctttgta acgtactcaa cagtagagga agctgttgcc acccgcacag ctctgcacgg     3420

ggtcaaatgg ccccagtcca atcccaaatt cctttgtgct gactatgccg agcaagatga     3480

gctggattat caccgaggcc tcttggtgga ccgtccctct gaaactaaga cagaggagca     3540

gggaatacca cggcccctgc accccccacc cccacccccg gtccagccac cacagcaccc     3600

ccgggcagag cagcgggagc aggaacgggc agtgcgggaa cagtgggcag aacgggaacg     3660

ggaaatggag cggcgggagc ggactcgatc agagcgtgaa tgggatcggg acaaagttcg     3720

agaagggccc cgttcccgat caaggtcccg tgaccgccgc cgcaaggaac gtgcgaagtc     3780

taaagaaaag aagagtgaga agaaagagaa agcccaggag gaaccacctg ccaagctgct     3840

ggatgacctt ttccgaaaga ccaaggcagc tccctgcatc tattggctcc cactgactga     3900

cagccagatc gttcagaaag aggcagagcg ggccgaacgg gccaaggagc gggagaagcg     3960

gcgaaaggag caagaagaag aagagcaaaa ggagcgggag aaggaagccg agcgggaacg     4020

gaaccgacag ctggagcgag agaaacgtcg ggagcacagt cgggagaggg acagggagag     4080

agagagagaa agggagcggg acagggggga ccgagatcgg gatagggaaa gggaccgaga     4140

acgaggcagg gaaagggatc gcagggacac caagcgccac agcagaagcc ggagtcggag     4200

cacacctgtg cgggaccggg gtgggcgccg ctagctggga aaacactaga gctgcaggta     4260

ccagccactc ggccccaggg ggttatggcc acagagggat aggcacagtc tccaccaccc     4320

tggagccaag ggtctttcac atcacctatc cctacataca taccaaatgg aaaagtggcc     4380

atccttttcc ccccaaacac acccccttaa cctatctctt gggacttagc ccgaccctcc     4440

ctctcatttc ccattaagtc tgagaggcaa gagctaggtt aggcaaggag gtggttggcc     4500

agagatgggg aacagccagg tgccccagtc ctctgatttt tcctccatcc tgcttaccac     4560

ctccctgggt acttacagcc ttctcttggg aacagccggg gccaggactg ggtcacctat     4620

gagctgaatc agcatctcct cctgagtccc agggcccctg cagttcccag tctcttctgt     4680

cctgcagccc ttgcctcttt cccacaggtt ccactttata tccacctttt ccttttgttc     4740

aatttttatt tttatttttt ttattattaa atgatgtggt ctatggaaaa aaaaataaaa     4800

atctgactta gtttt                                                      4815


<210> 3674
<211> 2038
<212> DNA
<213> Homo sapiens

<400> 3674
gtggggccgc cgttgccaga gaagccacta gccggttact agctgcgctt ttgttccact       60

tgagcgggca ctcttctgcg gcaagcaggt ctaggaattc gcctggttcc cacctcgcgt      120

cccttgcctt ccttcctagt ctacccactg tagtgccccc tgcgtcccgc tccctcctag      180

ccgactcaga gcacaagaag gattgccacg gtttccattg cagcagccgt ggcgcctctg      240

accctttttt tatatcgcgg cgacggcggg ctgtcgtcac gacgacgtgc ggacgcagcg      300

gcgggggcct ttcagcttat gtggagaagt cgctgtgaag ccacctataa atccatttac      360

tgaatttatg gagaaggctg taaatgatgg aagtcattca gaagaactct tttgccatct      420

taaaactata tcagagaaag aagatttacc acggtgtacc agtgaaagtc atctcagctg      480

cctgaagcag gacattctaa atgaaaagac tgaattggaa gcaacactta aggaagcgga      540

gttggtaact cattctgtag aattgctttt gccactattt aaggacacca ttgaaaagat      600

taattttgaa aatgcgaatc tttctgcatt gaatttgaag atttctgaac agaaggaaat      660

attaataaaa gaattagaca ccttcaaaag tgtaaaacta gctttagaac atcttcttag      720

aaagagagac tacaaacaaa caggagacaa tttatccagc atgttgctag aaaatctaac      780

tgataatgaa agtgaaaata ctaatcttaa gaagaaggta tttgaaaagg aggcccatat      840

ccaagaactt tcttgtttgt ttcagagtga aaagagctta gaaaccaaga tagccaagtg      900

gaacctgcaa tcaagaatga ataagaatga ggctatagtg atgaaagaag caagtaggca      960

aaaaactgta gctttaaaaa aggcatctaa agtttacaaa caaaggcttg accattttac     1020

aggagctatt gaaaagctta cttcccaaat tagagatcag gaagccaagt tgtctgaaac     1080

aatttcagct tccaatgcct ggaaaagtca ttatgagaaa attgtgatag aaaaaaccga     1140

attggaagta cagattgaaa caatgaaaaa gcaaatcatt aatcttttgg aagatctgaa     1200

gaaaatggaa gaccatggaa aaaattcatg tgaagaaatt cttagaaaag ttcactcaat     1260

tgaatatgaa aatgaaactc tgaatcttga gaatacaaaa ttaaagacta cacttgctgc     1320

tttgaaggat gaagttgtat ctgttgaaaa tgaactctca gaattgcaag aagtagaaaa     1380

aaaacagaaa acccttattg aaatgtataa aactcaggta caaaagttgc aagaagcagc     1440

tgaaatagta aaaagcagat gtgaaaattt gctacataaa aataaccaaa taacaaaaac     1500

caaaaataaa aatgtagaga aggttgatgg aaatcacaat cttctgacaa agctttctct     1560

ggaagaggaa aactgtctta ttcagctgaa gtgtgaaaac cttcaacaaa aattagaaca     1620

gatggacgca gaaaataaag agcttgagaa gaagctggca aaccaagaag aatgtcttaa     1680

gcacagcaat cttaagttta aagagaaatc tgcagagtat acagcattgg ccagacaact     1740

ggaagctgct ttagaagaag gaagacaaaa ggttgctgaa gaaatagaga aaatgtcatc     1800

tagagagagt gctttacaaa ttaaaatatt agatctggaa actgagctta gaaagaaaaa     1860

tgaagaacaa aatcaacttg tttgcaaaat gaacagtaaa gcacaacatc aggaagtgtg     1920

tttgaaagaa gtacaaaata gtcttgagaa gtcggaaaat caaaatgaga gtattaagaa     1980

ttatttacag tttcttaaaa cttcttatgt aacaatgttt gaataaattg tcaaattt       2038


<210> 3675
<211> 1847
<212> DNA
<213> Homo sapiens

<400> 3675
ggtggagggt ggaacgcggg cgcctgaagg agttgttgtc tcggcagcgc ccgcggagac       60

gtgaagaggt ggttgtggga agagaagttt gcagaactga aatggaggtc agagcttcat      120

tacagaaggt tagtggatca tctgattctg tggctacaat gaacagtgaa gaatttgttt      180

tggttcctca gtatgcagat gataattcta caaaacatga agaaaaacct caactgaaga      240

tagtttctaa tggtgatgaa caattggaaa aagccatgga agagattttg agagattccg      300

agaaaaggcc aagcagtctt cttgttgatt gtcaaagttc cagtgagatt tcagaccatt      360

cgtttggaga tattccagcc agccaaacaa ataagccatc tcttcagtta attttggatc      420

cgtctaacac agaaatttct acacccagac catcttctcc aggtggacta cctgaagaag      480

atagtgtttt atttaataaa ctgacctact taggatgtat gaaggtttct tccccacgta      540

atgaagtaga ggctttacgg gcaatggcaa ccatgaaatc ttccagtcaa tacccctttc      600

ctgttaccct gtatgtacca aatgttccag aaggttctgt gagaattata gaccaatcca      660

gcaatgtgga gatagcatct tttccaatct ataaggtgtt attctgtgca cgtggacatg      720

acggaacaac agagagcaat tgctttgcat ttacagagag ttcccatggt tcggaagaat      780

ttcagataca tgttttctcc tgtgaaatta aagaggcagt aagcagaatt ttgtacagtt      840

tctgtacagc attcaaacgt tcttccagac aagtgtctga tgttaaagac tcagttattc      900

ctacccccga cagtgatgtg tttaccttca gtgtctcctt ggaggtaaaa gaagacgatg      960

gaaaaggaaa ctttagatta ttggtaattc ctattccttt tgaatatttc agccctgtgc     1020

ctaaggatag agataaattt tatttcaaat taaagcaagg aatagagaag aaggttgtga     1080

ttacagtgca gcaactttct aacaaagaat tagctattga aagatgtttt ggaatgttat     1140

taagcccagg tcgaaacgtg aagaacagtg acatgcattt actggatatg gaatccatgg     1200

gaaagagcta tgatgggaga gcttatgtca tcactggcat gtggaacccc aatgcaccag     1260

tatttctggc acttaacgag gaaaccccaa aagataagca agtatacatg actgtggcag     1320

tggatatggt agtcacagag gtggtggagc ctgttcgctt tctcctggag acagtagtcc     1380

gtgtgtaccc tgcaaatgag cgattttggt atttcagcag aaagactttc acagagactt     1440

tcttcatgag attgaaacag tctgagggaa aaggccatac caatgctgga gatgcaatat     1500

atgaggtggt gagtctacag cgagagtctg acaaggagga accagtcact cctactagtg     1560

gagggggtcc aatgtcaccc caggatgatg aagcagaaga ggagagtgat aatgaactct     1620

caagtggaac aggtgatgtg tctaaggatt gtcctgagaa gatcctgtat tcttggggag     1680

agttgctagg aaaatggcac agtaaccttg gtgcacgacc gaaagggctg tctactctgg     1740

tgaagagtgg tgtccctgaa gcattgaggg cagaggtatg gcagttattg gcaggctgcc     1800

atgacaacca ggcaatgctg gatagatacc gaattcttat cacaaag                   1847


<210> 3676
<211> 865
<212> DNA
<213> Homo sapiens

<400> 3676
gggtcccccg gcccctgcag ggctacttgg gcgcagagcc gcggagggtc tccgttccta       60

gaggtcctcc tatcccgggc tgcctgagtc ctcgccagca tccgccctct cccactccca      120

tccttcctgg atccgcctct cggttcccga gggacagtcc cgaccgcaaa cccacgtaga      180

gtaaggaatg tgggacaggc gacagaagtg gcatacggtc ctgcgttatc cctccgtctc      240

gccacacctt gtgtctccat ctctccccac ttccttccct ccgtctgtca tctgtcatcc      300

ccggtcgctc taagaccagg attccaattc gcctagtgag gaatctcact aggggaattt      360

atcgcgacat cataaattaa cgggttcatt ttgactgaaa aagcgaagga cttttttcag      420

gcagaaaaca agtctcgtct ggacgcgtct agtctattta ttgtcgcggg gaagctgcgg      480

ccgcctcgca cccggaacaa caaagcaagg aagacggagt ccgagcctcg ggggctccta      540

gcaacgggcc ggggcgggag ttccatggag actggggagc gcgcccgtct catcctcatc      600

cttgtcctcc agcttctcct tcgcatccga cgcaaccggc agcagcgctg ccgccgcgtc      660

ctcagccacc gctccctctt cccacggatg tgatcttcgt ggtggaaagc taaattttaa      720

aaccacccca atggatgcag acagtgatgt tgcattggac attctaatta caaatgtagt      780

ctgtgttttt agaacaagat gtcatttaaa cttaaggaag attgctttgg aaggagcaaa      840

tgtaatttat aaacgtgatg ttgga                                            865


<210> 3677
<211> 1086
<212> DNA
<213> Homo sapiens

<400> 3677
gccacgcgtg cgcttaggcg ccgctgagcg ctgactgggt gcgagtgggg aagctgctaa       60

cccgacccgg attggcgctg aggtggcccg tggggcaggg cagatgattc tggaccagat      120

gaagcctgag gagccttcca gctctaagat agcaggatag gagacttcta agattggagc      180

tgcagaagac ttgccagccc accagcacaa tgtcagaagg aagagtcagc agagcaacca      240

gagttctact acgatgagtt tggtttccgt gtgtacaagg aagaaggtga tgagcctggc      300

tccagtctgc tggcgaactc ccctctgatg gaggatgctc cacagaggct gcggtggcag      360

gcccacctgg agttcaccca taaccacgat gtgggggatc tcacctggga caagattgcc      420

gtctccctac cccgctctga gaagctccgc tccctggtgc tggccggcat cccacatggc      480

atgaggccac agctgtggat gcggctctct ggggccctgc agaagaagag gaactctgag      540

ctgtcctacc gcgagattgt gaagaacagc tccaacgatg agaccatcgc tgccaagcag      600

atcgagaagg acctgctccg caccatgccc agcaacgcct gcttcgccag catgggtagc      660

atcggggtgc cccgcctgcg cagggtgctc cgggccctgg cctggctcta cccagagatc      720

ggctactgcc agggcaccgg catggtggcc gcctgcctcc tgctgttcct ggaggaggag      780

gacgccttct ggatgatgtc tgccatcatc gaggacctgc tccccgcctc ctacttcagc      840

accaccctgc tgggtgtcca gactgaccag cgggtcctgc gccacctcat tgtccagtac      900

ctgcctcgcc tggacaagct gctccaggag catgacattg agctgtccct gatcacactg      960

cactggttcc tcacggcctt cgccagcgtg gtggacatca agctgctcct gcgcatctgg     1020

gacctgtttt tctacgaggg ctcccgggtg ctgttccagc tcacgctggg catgctgcac     1080

ctcaag                                                                1086


<210> 3678
<211> 649
<212> DNA
<213> Homo sapiens

<400> 3678
tccactggtg aaagtgcaga tctttggcgt tcgtctagac acagcacggc aggagaccaa       60

ctatgtggag aacaatggtt ttaatccata ctgggggcag acactatgtt tccgggtgct      120

ggtgcctgaa cttgccatgc tgcgttttgt ggtaatggat tatgactgga aatcccgaaa      180

tgactttatt ggtcagtaca ccctgccttg gacctgcatg caacaaggtt accgccacat      240

tcacctgctg tccaaagatg gcatcagcct ccgcccagct tccatctttg tgtatatctg      300

catccaggaa ggcctggagg gggatgagtc ctgaggctca atcccatacc gacatctaca      360

actaatcttt cccatcaact ctgtgtgaag gcaggttgca actagaaatt cagaggggct      420

tggaatagag aaacctaaag aagcatcatc ccctccatcc ccaacttcct caaagcccaa      480

agccaaggga aggataaatc aaggctcaag gcttccccag caaagattag ggaaagagac      540

ttgaccccag gactgtacta cgactcttaa gagaacactg cacagcactc aaagtccccc      600

actggactgc ttcctcctta gccccactgg tataaataca tctctctcc                  649


<210> 3679
<211> 1902
<212> DNA
<213> Homo sapiens

<400> 3679
aagggcccag agctctggcc ggcggacctt ttccttctgg agtttccccg gcgggtgcca       60

gggctcgacc cacagagcac cctcagccat cgcgagtttc cgggcgccaa agccaggaga      120

agccgcccat cccgcagggc cggtctgcca gcgagacgag agttggcgag ggcggaggag      180

tgccgggaat cccgccacac cggctatagc caggccccca gcgcgggcct tggagagcgc      240

gtgaaggcgg gcatcccctt gacccggccg accatccccg tgcccctgcg tccctgcgct      300

ccaacgtccg cgcggccacc atgatgcaaa tctgcgacac ctacaaccag aagcactcgc      360

tctttaacgc catgaatcgc ttcattggcg ccgtgaacaa catggaccag acggtgatgg      420

tgcccagctt gctgcgcgac gtgcccctgg ctgaccccgg gttagacaac gatgttggcg      480

tggaggtagg cggcagtggc ggctgcctgg aggagcgcac gcccccagtc cccgactcgg      540

gaagcgccaa tggcagcttt ttcgcgccct ctcgggacat gtacagccac tacgtgcttc      600

tcaagtccat ccgcaacgac atcgagtggg gggtcctgca ccagccgcct ccaccggctg      660

ggagcgagga gggcagtgcc tggaagtcca aggacatcct ggtggacctg ggccacttgg      720

agggtgcgga cgccggcgaa gaagacctgg aacagcagtt ccactaccac ctgcgcgggc      780

tgcacactgt gctctcgaaa ctcacgcgca aagccaacat cctcactaac agatacaagc      840

aggagatcgg cttcggcaat tggggccact gaggcgtggc gcccgtggct gcccagcacc      900

ttcttcgacc catctcaccc tctctcattc ctcaaagctt tttttttttt tcctggctgg      960

ggggcgggaa gggcagactg caaactgggg ggctgcgtac gtgcaggagg cgcggtgggg     1020

ctgcgtggag gagggggcca cgtgtgagag agaagaaaat ggtggccgga gatgggaggg     1080

cccaaggaac ctcctgggag ggggcctgca ttctatgttg gtgggaatgg gactgggctg     1140

acgccctgca ttcagcctgt gcctttcctg gggtttcttt tctgttcttt tcggaggaga     1200

gggcccgaga aggggccata ccagggcgcg gcgctgggtt gccacacttg ggaaagcagc     1260

ccggagctgg gtgctgggga aggcggggcg cgtagcctcc cgccgccctg cggttgggcc     1320

ggtggaggcc caggcgttgc taggattgca tcagttttcc tgtttgcact atttcttttt     1380

gtaacattgg ccctgtgtga agtatttcga atctcctcct tgctctgaaa cttcagcgat     1440

tccattgtga taagcgcaca aacagcactg tctgtcggta atcggtacta ctttattaat     1500

gattttctgt tacactgtat agtagtccta tggcaccccc accccatccc tttcgtgcca     1560

ctcccgtccc cacccccacc ccagtgtgta taagctggca tttcgccagc ttgtacgtag     1620

cttgccactc agtgaaaata ataacattat tatgagaaag tggacttaac cgaaatggaa     1680

ccaactgaca ttctatcgtg ttgtacatag aatgatgaag ggttccactg ttgttgtatg     1740

tcttaaattt atttaaaact ttttttaatc cagatgtaga ctatattcta aaaaataaaa     1800

aagcaaatgt gtcaactaaa ttggacaagc gtctggtcct cattaatctg ccaatgaatg     1860

gtttcgtcat taaataaaaa tcaatttaat tgatttacta gc                        1902


<210> 3680
<211> 1856
<212> DNA
<213> Homo sapiens

<400> 3680
attactcgct tacgtgagca gaagtagttc tggtcgtcgt ctaccgtctc gctatagccg       60

tttgagggaa gaaggaggaa aattacccgc tacaccaaaa ttgcattgag ccaaacttgc      120

caccaagagc ccaacaatca ccatgatgct gagcacggaa ggcagggagg ggttcgtggt      180

gaaggtcagg ggcctaccct ggtcctgctc agccgatgaa gtgatgcgct tcttctctga      240

ttgcaagatc caaaatggca catcaggtat tcgtttcatc tacaccagag aaggcagacc      300

aagtggtgaa gcatttgttg aacttgaatc tgaagaggaa gtgaaattgg ctttgaagaa      360

ggacagagaa accatgggac acagatacgt tgaagtattc aagtctaaca gtgttgaaat      420

ggattggatg acactgccag tggactttca ggggcgaagc acaggggaag cctttgtgca      480

gtttgcttca caggagatag ctgagaaggc cttaaagaaa cacaaggaaa gaatagggca      540

caggtacatt gagatcttca agagtagccg agctgaagtt cgaacccact atgatccccc      600

tcgaaagctc atggctatgc agcggccagg tccctatgat aggccggggg ctggcagagg      660

gtataatagc attggcagag gagctgggtt tgaaaggatg aggcgtggtg cctatggtgg      720

agggtatgga ggctatgatg actatggtgg ctataatgat ggatatggct ttgggtctga      780

tagatttgga agagacctca attactgttt ttcaggaatg tctgatcata gatacggaga      840

tggtgggtcc agtttccaga gcaccacagg gcactgtgta cacatgaggg ggttacctta      900

cagagccact gagaatgata tttataattt cttctcacct cttaatccca tgagagtaca      960

tattgaaatt ggacccgatg gcagagttac cggtgaggca gatgttgaat ttgctactca     1020

tgaagatgct gtggcagcta tggcaaaaga caaagctaat atgcaacaca gatatgtgga     1080

gctcttctta aattctactg caggaacaag tgggggtgct tacgatcaca gctatgtaga     1140

actttttttg aattctacag caggggcaag tggtggcgct tatggtagcc aaatgatggg     1200

agggatgggc ttatccaacc agtctagtta tggaggtcct gctagccagc agctgagtgg     1260

tggttatgga ggtggttatg gtggtcagag cagtatgagt ggatatgacc aagttctgca     1320

ggaaaactcc agtgactatc agtcaaacct tgcttaggta gagaaggagc actaaatagc     1380

tactccagat ataaaagctg tacatttgtg ggagttgaat agaatgggag ggatgtttag     1440

tatatccagt atgattggta aatgggaaat ataattgatt ctgatcactc ttggtcagct     1500

tctctttctt tatctttctt tctccttttt taagaaaacg agttaagttt aacagttttg     1560

cattacaggc ttgtgattca tgcttactgt aaagtggaag ttgagattat tttaaaactt     1620

caagctcagt aattttgaac actgaaacat tcatctagga cataataaca aagttcagta     1680

ttgaccataa ctgttaaaac aatttttagc tttcctcaag ttagttatgt tgtaggagtg     1740

tacctaagca gtaagcgtat ttaggttaat gcagtttcac ttatgttaaa tgttgctctt     1800

ataccacaaa tacattgaaa acttcggatg catgttgaga aacatgcctt tctgta         1856


<210> 3681
<211> 4192
<212> DNA
<213> Homo sapiens

<400> 3681
tttcccttag taacagcttt taccttctgc ctcaattcct ctccccgctc gcgcccttcc       60

cccgcgcgcc gcctcccccc gccgccggcc gcgtgcgccc ccgcccctcc ccccgcggcg      120

ggagcacctc cgctcgccac ctggggaccc gcgccgcgct ccccgccccc gcccgcccgg      180

cgcccatccc ccgcgccctc cgctcgctgg ggttataatt gcctctcacc ccccggaggg      240

gttattttgg gggtggttgg aggcggtggc ggcggcggcg aggaggggaa tttccttgtg      300

cctccattcc cgggaggggg gagcggcgtt ggaggccacc gtttccagca tcaacaacag      360

caacttgtga ttggcggtga ccggatattc agttgcacat ccccacatca atgcactgcc      420

aatgggttat atcctgtgtt gtgacctcat ggtttaagtg ggaataaaga tgagtataag      480

cagtgatgag gtcaacttct tggtatatag atacttgcaa gagtcaggat tttctcattc      540

agcatttacc tttggtatag aaagccatat cagtcagtcc aatataaatg gtgccctcgt      600

cccacccgct gcattgattt ctatcatcca gaaaggtcta cagtatgtag aagcagaagt      660

tagtattaat gaggatggta ccttgtttga tggtcgacca atagagtctc tgtccctgat      720

agatgccgta atgcctgatg tagtacaaac aagacaacaa gcttatagag ataagcttgc      780

acagcaacag gcagcagctg ctgcagctgc cgcagctgca gccagccaac aaggatctgc      840

aaaaaatgga gaaaacacag caaatgggga ggagaatgga gcacatacta tagcaaataa      900

tcatactgat atgatggaag tggatgggga tgttgaaatc cctcctaata aagctgttgt      960

gttgcggggc catgaatctg aagtttttat ctgtgcctgg aaccctgtta gtgatctcct     1020

agcatcaggg tctggagact caacagcaag aatatggaat cttagtgaga acagcaccag     1080

tggctctaca cagttagtac ttagacattg tatacgagaa ggagggcaag atgttccaag     1140

caacaaggat gtcacatctc tagattggaa tagtgaaggt acacttctag caactggttc     1200

ctatgatggg tttgccagaa tatggactaa agatggtaac cttgctagca ccttagggca     1260

gcataaaggc cctatatttg cattaaaatg gaataagaaa ggaaatttca tcctaagtgc     1320

tggagtagac aagactacaa ttatttggga cgcacatact ggtgaagcca agcaacagtt     1380

tccttttcat tcagcaccag cattggatgt tgattggcag agcaacaaca cctttgcttc     1440

ttgtagtaca gatatgtgca ttcatgtctg taaattagga caagacagac ctattaaaac     1500

attccaagga catacgaatg aagtaaatgc tatcaaatgg gacccaactg gcaatctctt     1560

ggcctcctgt tctgacgaca tgactttaaa gatatggagt atgaaacaag acaattgtgt     1620

ccatgatttg caagcacata ataaagaaat ttatactatc aaatggagtc caacaggacc     1680

agggactaat aatccaaatg ccaaccttat gttagcaagt gcatcctttg attctactgt     1740

taggttatgg gatgtagacc gagggatatg catccatacc ttgacaaaac accaagagcc     1800

tgtgtacagt gtagctttca gtcctgatgg caggtatctg gcaagtggtt cttttgacaa     1860

atgtgtacac atctggaaca cgcagacagg tgctctagtt cacagctata ggggaacagg     1920

tggaatattt gaagtttgct ggaatgcagc aggagacaaa gttggagcca gtgcatcaga     1980

tggttcagtt tgtgtattag accttcggaa atagcgctac tagttggaag ccatggaccg     2040

actatgaatg tgtacatagc caaaatgact gtccctgacc catgtactgc tatagtccca     2100

cttgaaccat ggccagtcca ctacagccaa atctaaaaga aatatataca tacagtgtat     2160

ataaacaaaa ttgcaccctg aagatgacag agttttgtca cagcttgtga attctgttca     2220

ccaagtgctg gaatctaatc tgctgtgccc ctaaaatagc atttagaagt tttggatatg     2280

aaaaacagaa gagagaaaaa tatacattat aaaagcagaa catacatgta ccagtttttg     2340

gatactaaat gacagccttg tttctcccct ttgaatcagc agacaccatg gattatattc     2400

tttttttccc ttcagtagtg agcagtttgt atgtacagag aaaatggact tacaaaaact     2460

tgcagcagta gtttgttctt gctttaaaat ttcgtttttg gtttagatta tggatgcatg     2520

aagtaaggga gtgaatcagt ttcttgttta tatttttttc accttttaaa caaaaaattc     2580

tttaaaatat tttaatgcat tcttttgaag aggtagatgt ttggtacatt ttatggctcc     2640

cagagcatat attcagttgg tgcatgttgt ggaaggggga attggaaatt aaatgaaaac     2700

ctatgacttt ggtcatgtca atctgtaaga cacatcagta aaagggtatt atgctctgtt     2760

ggttttgttt ttttgttttg cttttttttt ttttttttct tttttgtttt ttggtgatgt     2820

ggcttaaatg caatagtttc ttttttggga catatttctg ccaattaaag actagaaggg     2880

cacaactttt tttttaatta ccatagagaa gatacattaa aaaaaatctt ctgatgtttt     2940

gtagccataa ctaaattatg gtaaaaatgt gcactattgt gaaaaggagc aacgtagttt     3000

tgggtttttt gttgtttgtt tgttttgctt tgttttttaa gagattaaaa tgtttctgga     3060

taaggattag cttctcgaag tgtccatcat tctgtgtaga agcttaaata tgtaatgtaa     3120

ccaaactcca gtattaaaaa tctctcatgt tgttttcttt atacaaagca agataacggc     3180

atataacact gccattacat ggcaaaatgt ttgctacctt agtttaaaaa acaatctcaa     3240

acaaaagact tgcttcaagg tgtttttaaa tagcagtgat tcagaatttt ttttaatgaa     3300

agtataattg cactaacctt cttcctgctg ctctgattct gcatttgtgg tacttgtgac     3360

tacgtttttt caaatataga tagatttaag ctgctaattt tttttttttt agtaatcact     3420

actatatcat gtcttttact ctgtttataa tatcaagtat tttcttaaag atatagatat     3480

taaaccttgt gctcatgcaa cttagagtaa catatacaga caaatgattg catgaggcca     3540

tgtttatatg tgtgactaat aaggcttgtc atgattaaca taatccaggt atgtcatttc     3600

tgaagagaat agtcatcaaa tttatatctc gaagatttta attaaggaat tgcttattgt     3660

tgagcttagc aaattaataa cactatttct gtcactaatt attttgaggc cttttagtac     3720

taaaatttta acctgtgttc taagtagaaa ctgatttaac ccaagtaatg cagctttgat     3780

tgatttcagc attcgttgct ttgctatttt tacaaaacag cattgattga agcaagtctt     3840

ggttttacta aggtagggta gcatttgcta ttggtaaaga gaataaatac acttaatttc     3900

acaatacatt gttatatgta ccccagttgt tgttagtggg gactatgata ctgtaataat     3960

atttttaaaa atttacatca agagaggcag tcattcacga tggttttgtg ccagctcttt     4020

ttagggtttt ggatcacatt agagatattt agaacatatt accctgtgac ttacgtagga     4080

aacctaatat gctgagtatc tggcacttga attcctgctt ttattgctgg aggtccacat     4140

ctgtggttga cctctgttat tgtttaaaaa aaataaataa aaattaaaaa aa             4192


<210> 3682
<211> 3767
<212> DNA
<213> Homo sapiens

<400> 3682
gttgcctgat gacgagagtt gggagtgtgg ctggggctgc ggatctccag cagtggcgtt       60

acttctagcg gctggatacc gggttctccg cgagatcgcg agatcccgag atattctccc      120

cgcacggaag cgacgactgg cctggccaga ggactcgcgt gggagcgagg tgccggcccc      180

gacaggacgg tgagaaattg ttttacagcc tacccgtata ttacaagaaa tctcaagtca      240

aacactggaa aagatgtcag aagattcaga aaaggaagac tattcagaca gaacaatcag      300

tgatgaagat gaatcggatg aggatatgtt catgaaattt gtaagtgaag atcttcatcg      360

gtgtgcactt ttaacagctg actcttttgg tgatcccttc ttcccccgga ctacacagat      420

actattagaa tatcagctag ggagatgggt gccacgtctt cgtgaaccaa gggatttata      480

tggtgtctct tcttctggtc cattgagccc aacacggtgg ccataccatt gtgaagtcat      540

cgatgaaaaa gtccagcata ttgattggac tccttcttgt cctgagccag tgtatatccc      600

aacgggctta gaaacggaac ccctttatcc agactccaag gaagctactg tggtttatct      660

agctgaagat gcttacaaag agccctgttt tgtgtattcc cgagttgggg gtaaccgaac      720

acctttgaag cagcctgtgg attaccgtga caatactttg atgtttgaag caaggtttga      780

gagtggtaat ctacagaagg tagtcaaagt ggcagaatac gaataccaat tgactgtacg      840

ccctgacctc ttcacaaata aacacaccca gtggtactat ttccaagtca ctaatatgcg      900

agcaggaata gtctacagat tcactattgt caacttcacc aaacctgcta gtctttacag      960

tcggggtatg cgcccactgt tctattctga aaaagaggcc aaggctcatc acattggctg     1020

gcagagaata ggagaccaaa tcaagtatta taggaacaac ccaggccaag atgggcgcca     1080

ttatttctct cttacatgga catttcaatt tccacacaac aaagatacct gctactttgc     1140

tcattgctat ccatacactt acaccaacct gcaagaatac ctttctggca tcaataatga     1200

tccagtacgg tcaaagtttt gtaaaatacg tgttttgtgc cacacgcttg ctaggaacat     1260

ggtgtatatt ttaacaatca ctaccccctt gaagaactct gactcaagaa agcggaaggc     1320

tgtgattctg actgcaaggg tccatccagg ggaaaccaac agctcttgga tcatgaaagg     1380

cttcctagat tatattttag gaaactcaag tgatgcacag ttgcttcggg acacttttgt     1440

cttcaaggtg gtacccatgc tcaatccaga tggtgtgatt gtgggaaatt atcgctgttc     1500

cttagctgga cgggatttaa accgtaatta tacatctctc ctgaaggaat cttttccttc     1560

tgtatggtat acccggaaca tggttcatag actgatggag aaacgagagg ttattttata     1620

ctgtgatctt catggccata gtaggaaaga gaacatcttc atgtatggct gtgatggtag     1680

tgacagatct aagacattat acttacagca acgaatcttc ccacttatgc taagcaaaaa     1740

ttgtccagat aaattttcat tctcagcttg caagtttaat gtccagaaga gcaaagaagg     1800

aacaggaagg gtggtaatgt ggaaaatggg aatcaggaac agctttacca tggaggccac     1860

cttctgtgga tctactctgg gtaacaaacg aggcactcat ttcagcacga aagacctgga     1920

atcaatggga tatcattttt gtgattctct cttggattat tgtgatcccg accggaccaa     1980

gtattatcgg tgcctgaaag aattagaaga aatggaaaga catataaccc tggaaaaagt     2040

ctttgaggat tcagacacac ctgtgataga cattacattg gatgtagagt ctagtagccg     2100

aggctctgac agttcagaat ccattgactc tctgacttac cttctcaagt taacttctca     2160

gaaaaaacat ttgaaaacaa agaaggaaag gaattctacc atagcaagcc accaaaatgc     2220

cagaggacaa gaggtttatg atagagggca tttgctgcaa agacacacac aatcaaattc     2280

tgatgtgaaa gatacaaggc caaatgaacc agatgattat atggttgatt atttcagaag     2340

acaattacct aatcaaggtt tggctcactg caagctccgc ctcccaggtt cacgccattc     2400

tcctgcctca gcctcccgag tagctggaac tacaggcacc cgccaccata cctggctaat     2460

ttttgtattt ttagtagaga tggggaaaaa aattcccctc aagggaactg atttgtatgg     2520

aaactgtttc aaagtgacat ccctgcagtc tcctatgggc aaacaaactt ctacttggac     2580

tgagaagaca aggataccaa cagaagatct gcaccacaac ttaaaaagca aaataaaaga     2640

atgcatatct ttccaaagca agaagactgg cataaattgg acagatgatg aaaaaagaag     2700

ctacaaggat aaaggaatag ttcaaactca agaaatattg cagtatttgc tccccatcgt     2760

gcatagcact aaaaacatgc aaaccactca gataaaacag ctattcaatc caagaaccaa     2820

cttccaaatc caacatcaac taaatccggc tacttgcaga aatataaaga aatacagcac     2880

atcttggaca gcacccagaa atcacccttt tgtaatccaa ggggatgtta tggcaaactc     2940

ttcagaatgg gtccagtcta agccccacag gtcattggaa agtttatcac ctctcaaagg     3000

ccccaagaag aataaacatt ctcaaatctg ggccataaag aatgaagaca taaaacctct     3060

cagcagcaag tgggagactg cttcttcaag ctttggaatg gatgcaaatg ttctaaaata     3120

taagagtctt caagctgaag aaactaacca gcaaagctct aagcatacag ccctccatct     3180

aactaaaaat aaggatgagc aggccaataa gaatgatgga caacccacct tatatctgaa     3240

gttccaaagg gagagttaat ctagctttat actgctctga gaactgtgaa tgaaggataa     3300

catatgctta tgtagtaaaa agaaaaaaag gaaagccctc cccttcccct ttccctatct     3360

ctccccttac acatgcatat gcataaacta aaaattttag atatcccatc ttctgtagtg     3420

ggaacatctt tcagagattt aaaaagaaat ccagagaaaa tatggaaaaa tattaaagca     3480

gatatttata tttagttttt atcagcatgg aaaaaaatct ctgaagtttt gatttcttcc     3540

aaaactactt acacattcga caccaaaaaa acttaagaac tcaaagtagg aatgacatat     3600

aatatgtcac tgattttaac ctccctacta gacactttaa tcaattagtc aacaaacatc     3660

atttcctgat tttctgttat atcattagtg tgctaggaac catttctctc tactaggaga     3720

ttaccacata attgtacaga taaaacatac ctgaataaaa tgattac                   3767


<210> 3683
<211> 7941
<212> DNA
<213> Homo sapiens

<400> 3683
tcaagatggc ggccaaggtg gcgaagcagc agccgcggcg gcggcggcgg ctggagtgag       60

cgtccgactc gccgcgccga acgaggtccc ggtgtagggc cgcgcgccgt ggccgcgtcc      120

cactcctcag gccggggcgc acgtcggctc ccacgcttag ccagctcccg gtggtttcct      180

agaaacatga ttgtttattg gcattgatct cacagtctgg tgaggacttc tttactgata      240

atgtcaagtt caggttatcc tcccaaccaa ggagcattca gcacagaaca aagtcgttat      300

cctcctcact ctgtccagta tacatttccc aacacccgcc accagcagga gttcgcagtc      360

cctgattatc gttcctctca tcttgaagtg agtcaggcat cacagctttt gcagcaacag      420

cagcagcaac agcttcgaag gcgaccttcc ttgctttcag aatttcaccc aggttctgac      480

aggcctcaag aaaggagaac tagttatgaa ccgtttcatc caggcccatc cccagtggat      540

catgattcac tggaatcgaa gcgaccacgt ctggaacagg tttctgattc tcattttcag      600

cgtgtcagtg ctgcggtttt gcctttagtg cacccgctgc cagaagggct gagggcttct      660

gcagatgcta agaaggatcc agcattcgga ggcaaacatg aagctccatc ctctccaatt      720

tcggggcaac catgtggaga tgatcaaaat gcttcacctt caaaactctc aaaggaagag      780

ttaatacaga gtatggatcg tgtagatcga gaaattgcaa aagtagaaca gcagatcctt      840

aaactgaaaa agaaacaaca acagcttgaa gaagaggcag ctaaacctcc tgagcctgag      900

aagcccgtgt cccctcctcc tgtggagcag aaacaccgca gtattgtcca aattatttat      960

gatgagaatc ggaaaaaagc agaagaagct cataaaattt ttgaaggtct tggcccaaaa     1020

gttgaactgc cactgtataa ccagccatca gataccaagg tgtaccatga gaacatcaag     1080

actggagtac ctgcaaggcg catgatgaaa aaccaggtga tgaggaaaaa actcatttta     1140

ttttttaaaa gaagaaatca tgcaagaaaa caaagggaac aaaaaatctg ccagcgttat     1200

gatcagctca tggaggcatg ggagaaaaaa gtggacagaa tagaaaataa tcctcggagg     1260

aaagctaaag aaagcaaaac aagggaatac tatgaaaagc agtttccaga aattcgaaaa     1320

caaagagaac agcaagaaag atttcagcga gttgggcaga ggggagctgg tctttcagcc     1380

accattgcta ggagtgagca tgagatttct gaaattattg atgggctctc tgagcaggag     1440

aataatgaga aacaaatgcg gcagctctct gtgattccac ctatgatgtt tgatgcagaa     1500

caaagacgag tcaagttcat taacatgaat gggcttatgg aggaccctat gaaagtgtat     1560

aaagataggc agtttatgaa tgtttggact gaccatgaaa aggagatctt taaggacaag     1620

tttatccagc atccaaaaaa ctttggacta attgcatcat acttggagag gaagagtgtt     1680

cctgattgtg ttttgtatta ctatttaacc aagaaaaatg agaattataa agccctcgtc     1740

agaaggaatt atgggaaacg cagaggcaga aaccagcaaa ttgctcgacc ctcgcaagaa     1800

gaaaaagtag aagaaaaaga agaggataaa gcagaaaaaa cagaaaaaaa agaagaagaa     1860

aagaaagatg aagaggaaaa agatgaaaaa gaagactcca aagaaaatac caaggaaaag     1920

gacaagatag atggtacagc agaagaaact gaggaaagag agcaagccac accccggggg     1980

cgaaagactg ccaacagtca gggccgccgt aagggccgga tcaccaggtc catgacaaac     2040

gaagctgcag ctgccagtgc tgcagccgca gcggctactg aagagccccc accacctctg     2100

ccaccgccac cagaacccat ttctacagag cctgtggaga cctctcgatg gacagaagaa     2160

gaaatggaag ttgctaaaaa aggtctagta gaacatggtc gtaactgggc agcaattgct     2220

aaaatggtgg gaacgaaaag tgaagctcaa tgtaaaaact tctattttaa ctataaaagg     2280

cgacacaatc ttgacaacct cttacagcag cataaacaga aaacttcacg aaaacctcgt     2340

gaagagcgag atgtgtctca atgtgaaagt gtcgcttcca ctgtttctgc tcaggaggat     2400

gaagatattg aagcctccaa tgaagaagaa aatccagaag acagcgaagt tgaagctgtc     2460

aagcccagcg aggacagtcc tgaaaatgct acttctcgag gaaacacaga acctgcggtt     2520

gagcttgagc ccaccacgga aactgcaccc agtacatctc cctccttagc agttccaagt     2580

acaaaaccag ctgaagatga aagtgtggag acccaggtga atgacagcat cagtgctgag     2640

acagcagagc agatggatgt agatcagcag gagcacagtg ctgaagaggg ttctgtttgt     2700

gatcccccac ccgctaccaa agctgactct gtggacgttg aagtgagggt gccagaaaac     2760

catgcatcta aagttgaagg tgataatacc aaagaaagag acttggatag agccagtgag     2820

aaggtggaac ctagagatga agatttggtg gtagctcagc aaataaatgc ccaaaggccc     2880

gagccccagt cagacaatga ttccagtgcc acgtgcagcg ctgatgagga tgtggatgga     2940

gagccagaga ggcagagaat gtttcctatg gactcaaagc cttcactgtt aaaccccact     3000

ggatctatac tcgtctcatc tccgttaaaa ccaaatccac tggatctgcc acagcttcag     3060

catcgagctg ctgttatccc accaatggta tcctgcaccc catgtaacat accaattgga     3120

accccagtga gcggctatgc tctctaccag cgacacatta aagcaatgca tgagtcagca     3180

ctcctggagg agcagcggca gagacaagaa cagatagatt tggaatgtag aagttctaca     3240

agtccatgtg gcacatccaa gagtccaaac agagagtggg aagtccttca gcctgctcca     3300

catcaagtga taactaatct ccctgaaggc gttcggcttc cgacaactcg accaaccagg     3360

ccaccgcccc ctctcatccc gtcatccaaa accacagtgg cttcagaaaa accatctttt     3420

ataatgggag gctccatctc acagggaaca ccaggcactt atttgacttc tcataatcag     3480

gcttcctaca ctcaagaaac acccaagccg tcagtgggat ctatctctct tggactgcca     3540

cggcaacagg aatctgccaa atcagctact ttgccctaca tcaagcagga agaattttct     3600

ccccgaagcc aaaactcaca acctgagggt ctgttggtca gggcccaaca tgaaggtgta     3660

gtcagaggta ccgcaggagc catacaagaa ggaagtataa ctcggggaac tccaaccagc     3720

aaaatttcag tggagagcat tccatcccta cggggctcta tcactcaggg caccccggct     3780

ctgccccaga ctggcatacc aacagaggct ttggtgaagg ggtccatttc gagaatgccc     3840

attgaagaca gcagtcctga gaaaggcaga gaggaagctg catccaaagg ccatgttatt     3900

tatgaaggca aaagtggaca tatcttgtca tatgataata ttaagaatgc ccgagaaggg     3960

actaggagtc caagaacagc tcatgaaatc agtttaaaga gaagctatga atcagtggaa     4020

ggaaatataa agcaagggat gtcaatgagg gagtctcctg tatcagcacc gttagagggg     4080

ctgatatgcc gagcattacc cagggggagt cctcattctg acctcaaaga aaggactgta     4140

ttgtctggct ccataatgca ggggacacca agagcaacaa ctgaaagctt tgaagatggc     4200

cttaaatatc ccaaacaaat taaaagggaa agtcctccca tacgagcatt tgaaggtgcc     4260

attaccaaag gaaaaccata tgatggcatc accaccatca aagaaatggg gcgttccatt     4320

catgagattc caaggcaaga tattttaact caggaaagtc ggaaaactcc agaagtggtc     4380

cagagcacac ggccgataat tgagggttcc atttcccagg gcacaccaat aaagtttgac     4440

aacaactcag gtcaatctgc catcaaacac aatgtcaaat ccttaatcac ggggcctagc     4500

aaactatccc gtggaatgcc tccgctggaa attgtgccag agaacataaa agtggtagaa     4560

cggggaaaat atgaggatgt gaaagcaggc gagaccgtgc gttcccggca cacgtcagtg     4620

gtaagctctg gcccctccgt tcttaggtcc acactgcatg aagctcccaa agcacaactg     4680

agccctggga tttatgatga caccagtgca cggaggaccc ctgtgagtta tcaaaacacc     4740

atgtccagag gctcacccat gatgaacaga acttctgatg ttacaatttc ttctaacaag     4800

tctaccaatc atgaaaggaa atcgacactg acccctaccc agagggaaag tatcccagcg     4860

aagtctccag tgcctggggt ggaccctgtc gtgagccaca gtccgtttga tccccatcac     4920

agaggcagca ctgcaggcga ggtttatcgg agccacctgc ccacgcactt ggatccagcc     4980

atgccttttc acagggcttt ggatcctgca gcggctgctt acctgtttca gagacagctt     5040

tcaccaactc caggttaccc aagtcagtat cagctttacg caatggagaa cacaagacag     5100

acaatcttaa atgattacat tacctcacaa cagatgcaag tgaacttgcg tccagatgtg     5160

gccagaggac tctccccaag agagcagcca ctgggtctcc catacccagc aacgagagga     5220

atcattgacc tgaccaatat gcctccaaca attttagtgc ctcatccagg gggaacaagc     5280

actcctccca tggacagaat cacttatatt cctggtacac agattacttt ccctcccagg     5340

ccgtacaact ctgcttccat gtctccagga cacccaacac accttgcagc tgctgcaagt     5400

gctgagaggg aacgggaacg ggagcgggag aaggagcggg agcgggaacg gattgctgca     5460

gcttcctccg acctctacct gcggccaggc tcagaacagc ctggccgacc tggcagtcat     5520

ggatatgttc gctccccttc cccttcagta agaactcagg agaccatgtt gcaacagaga     5580

cccagtgttt tccaaggaac caatggaacc agtgtaatca cacctttgga tccaactgct     5640

cagctacgaa tcatgccact gcctgctggg ggcccttcaa taagccaagg cctgccagcc     5700

tcccgttaca acactgctgc ggatgccctg gctgctcttg tggatgctgc agcttctgca     5760

ccccagatgg atgtgtccaa aacaaaagag agtaagcatg aagctgccag gttagaagaa     5820

aatttgagaa gcaggtcagc agcagttagt gaacagcagc agctagagca gaaaaccctg     5880

gaggtggaga agagatctgt tcagtgttta tacacttctt cagcctttcc aagtggcaag     5940

ccccagcctc attcttcagt agtttattct gaggctggga aagataaagg gcctcctcca     6000

aaatccagat atgaggaaga gctaaggacc agagggaaga ctaccattac tgcagctaac     6060

ttcatagacg tgatcatcac ccggcaaatt gcctcggaca aggatgcgag ggaacgtggc     6120

tctcaaagtt cagactcttc tagtagctta tcttctcaca ggtatgaaac acctagcgat     6180

gctattgagg tgataagtcc tgccagctca cctgcgccac cccaggagaa actgcagacc     6240

tatcagccag aggttgttaa ggcaaatcaa gcggaaaatg atcctaccag acaatatgaa     6300

ggaccattac atcactatcg accacagcag gaatcaccat ctccccaaca acagctgccc     6360

ccttcttcac aggcagaggg aatggggcaa gtgcccagga cccatcggct gatcacactt     6420

gctgatcaca tctgtcaaat tatcacacaa gattttgcta gaaatcaagt ttcctcgcag     6480

actccccagc agcctcctac ttctacattc cagaactcac cttctgcttt ggtatctaca     6540

cctgtgagga ctaaaacatc aaaccgttac agcccagaat cccaggctca gtctgtccat     6600

catcaaagac caggttcaag ggtctctcca gaaaatcttg tggacaaatc caggggaagt     6660

aggcctggaa aatccccaga gaggagtcac gtctcttcgg agccctacga gcccatctcc     6720

ccaccccagg ttccggttgt gcatgagaaa caggacagct tgctgctctt gtctcagagg     6780

ggcgcagagc ctgcagagca gaggaatgat gcccgctcac cagggagtat aagctacttg     6840

ccttcattct tcaccaagct tgaaaataca tcacccatgg ttaaatcaaa gaagcaggag     6900

atttttcgta agttgaactc ctctggtgga ggtgactctg atatggcagc tgctcagcca     6960

ggaactgaga tctttaatct gccagcagtt actacgtcag gctcagttag ctctagaggc     7020

cattcttttg ctgatcctgc cagtaatctt gggctggaag acattatcag gaaggctctc     7080

atgggaagct ttgatgacaa agttgaggat catggagttg tcatgtccca gcctatggga     7140

gtagtgcctg gtactgccaa cacctcagtt gtgaccagtg gtgagacacg aagagaggaa     7200

ggggacccat cacctcattc aggaggagtt tgcaaaccaa agctgatcag caagtcaaac     7260

agcaggaaat ctaagtctcc tatacctggg caaggctact taggaacgga acggccctct     7320

tcagtctcct ctgtacattc agaaggggat taccataggc agacgccagg gtgggcctgg     7380

gaagacaggc cctcttcaac aggctcaact cagtttcctt ataaccctct gactatgcgg     7440

atgctcagca gtactccacc aacaccgatt gcatgtgctc cctctgcggt gaaccaagca     7500

gctcctcacc aacagaacag gatctgggag cgagagcctg ccccactgct ctcagcacag     7560

tacgagaccc tgtcggatag tgatgactga actgcacaaa gtgaggggaa cagggtgcag     7620

gagagggatc tctagttttt gtggtttaat ttttagtagc aggtcaaaaa cctgccctcc     7680

tgtgacttat tccctgagac ttttcaggag agccagccca cagatgatga agaaatgatg     7740

gaagttcatt tggagagtca aatgggaaaa aaacaaacaa aaaactgcct ttgatacagg     7800

caattcagtg gactataata atagtggagg gttgagatgt agagttttta aaaagtgaac     7860

agttgctgtt cttacatctg taaagaaaac cataatgtct ttaaatcact cttctgtaaa     7920

tagatgacct ttttgcagtg t                                               7941


<210> 3684
<211> 1618
<212> DNA
<213> Homo sapiens

<400> 3684
gaataagccc gagcagccgg tcctccagtg gctccgctcc ccgttctctg tgggctcaaa       60

atgacagagg ctcacaggac acctgcatgc ccaaggcact ccaccgtatg tgatcaacct      120

ggatccagca gtacatgaag ttccctttcc tgccaatatt ggtgatgaaa tttattgaga      180

aggcccagaa catgtccaaa tatgtgttga ttgacacacc tggacagatt gaggtattca      240

cctggtcagc ttctgggaca attatcactg aagcccttgc atcctcattt ccaacagttg      300

tcatctatgt aatggacaca tcgagaagta ccaacccagt gaccttcatg tccaacatgc      360

tctatgcctg cagcatctta tacaaaacca agctgccttt cattgtggtc atgaataaaa      420

ctgacatcat tgaccacagc tttgcagtgg aatggatgca ggattttgag gctttccaag      480

atgccttgaa tcaagagact acatacgtca gtaacctgac tcgttcaatg agcctggtgt      540

tagatgagtt ttacagctca ctcagggtgg tgggtgtctc tgctgttctg ggtactggat      600

tagatgaact ctttgtgcaa gttaccagtg ctgccgaaga atatgaaagg gagtatcgtc      660

ctgaatatga acgtctgaaa aaatcactgg ccaacgcaga gagccaacag cagagagaac      720

aactggaacg ccttcgaaaa gatatgggtt ctgtagcctt ggatgcaggg actgccaaag      780

acagcttatc tcctgtgctg cacccttctg atttgatcct gactcgagga accttggatg      840

aagaggatga ggaagcagac agcgatactg atgacattga ccacagagtt acagaggaaa      900

gccatgaaga gccagcattc cagaatttta tgcaagaatc gatggcacaa tactggaaga      960

gaaacaataa ataggagact ttagcacact tcacttgttt ctagaagtcc agaattttgg     1020

acctccacgt gaaagaactg ttcttacctc tgaactgggg gctcccataa gggataattt     1080

tcctcagagt agcaaagttt ctcttattag agaaatcttg tgactcagat gaagtcaggg     1140

atagaagacc cttggacctg gcaggttaat gctgattatt ccttggcctt tcccttgtat     1200

ttatgcaagg aaggatatac tgagctgata ctcttccaag cctacaactt caagttttat     1260

catttgaact caagtacttt tgctgctgag gaatggaatc aaaagaacgt agtctcctgg     1320

tgaccacctc agatctctat tattaggcta gatgtatagc ctctactccc ccagcttctt     1380

gctcttgacc ctgcactgta agttgccctt ctattagcag ccaaggaaaa gggaaacatg     1440

agcttatcca gaacggtggc agagtctcct tggcaatcaa ccaacgttgc tatgaaatat     1500

gcctcacact gtatagctca ttataggacg tcaggtttgt tgaaaaaagt gggcaagaca     1560

tgattaatga atcagaatcc tgtttcattg gtgacttgga taaagacttt ttaatttt       1618


<210> 3685
<211> 1677
<212> DNA
<213> Homo sapiens

<400> 3685
gtagtcataa aggtctcttt gccaagttac tgccctctca agctgcttcc agtgaatgct       60

acacacctgc accatggttt gtccgacatc cttagccaag atcaggattg gctatgttgg      120

tacttacata tcctcatgag aattgtggtt ctggtactag tttggtaaag aaattattaa      180

acctagctga tgcttgaagg tagttggatt aacaggaaag aaaagagact tcttttctag      240

ccaagatgaa agatacacaa gacattcagg aagcttcgaa ggcaatgcag aataaagtcc      300

atgagcagga agataagaat gagaaacaaa aacaaagaga agacaaactt ggagtatatt      360

ctttagtaca tttttcccca aagatgttgg gttcagttgc cacaacactg ccattgtcat      420

cttcaaattc cagtggaatg cctcttggtt actatctgtc tagtcctcag attagtagag      480

taactatatc aacaactgga caattgactt ctaaagctac tgtaggtagc tgttccagag      540

tggaaaacag cttggatgcc agccccttct cagttccgaa gaaacaggat gaatcaccca      600

tgattgggga tggagaagat tatttccttt ctttgtttgg tgattcaaag aaacttacag      660

cacactcaaa ctacactcag aaaactttaa aatacttttc tatgattctt gaagaagttg      720

gccaatttac ctccagttct cttggagatg ttgaaatagc tgaagtgaat gtcaagggtt      780

tgttcgtgaa gctcattaac tcttcccttg acaaagaaat ggcaattgga gatcatattc      840

tccagcaaaa tgtgaatgga caaaccattt ctttgtaccg attccttcca aacatcgtaa      900

tgcaggcaaa ttccacagta acagtgtggg cagcagcatc tgaagcaaag catcaacctc      960

catcagattt tctttggaag gaacaagaca agtttagagc aagtcctgat tgtataacaa     1020

tcctgtgcaa accgaacggt caagccattg cgtggtacac ccctatccac tggaagcaag     1080

cgtgggaaaa attagatgct gacgttgaat ttaacagatg ttcagtagta tctccaacat     1140

tccgaaagcg tgtgtttcag tggacagcat ctacagctac aataactaaa gaaaaacaag     1200

atcaacctaa gaaagatatc tcaaattatc aggtggaaca agctcaagtt cttcttaaga     1260

gagagaagga aatcccacca accgttttcc ctaatcgcag cccttggtgc cagaatccct     1320

atgtctctgc acatccttac tgtcctctga ttgaaccaca caatacatcc accgctggag     1380

gcagattgga tagacagccc aggactcggt caaccagacc taatcgagcc tcagggtcta     1440

agaaaaagaa gacatctgag tcacaaaagc aataagcagt caactcaacc tttaaagtaa     1500

tctagtccac cctcaaccag ctactagaaa agcaaaagag aactcaaatc cctgaggcct     1560

gctctgcaac ctccctgcta ttccatgaga gggtgaagac atcacatttc tatatggaaa     1620

aaggatccaa aatttgtatt gctgtagaat tggtgaatta tagatgcttg atgaaat        1677


<210> 3686
<211> 3097
<212> DNA
<213> Homo sapiens

<400> 3686
cagttcgatc aaggttgacg atgtgtcaca ctgtgtaagg gaatcgcatg gagatgggca       60

ttccgaactg ttaatgggga catgggactc cagttgtctc tgatcacttg tgtggatttt      120

cctggcgtag aacgacagaa gccgctagta agtcgccaag acctacagca ggaattctgc      180

accaaagggc ataaaatctt gttattttaa tttgcatctg ggagaatgtc tgagcaagga      240

gacctgaatc aggcaatagc agaggaagga gggactgagc aggagacggc cactccagag      300

aacggcattg ttaaatcaga aagtctggat gaagaggaga aactggaact gcagaggcgg      360

ctggaggctc agaatcaaga aagaagaaaa tccaagtcag gagcaggaaa aggtaaactg      420

actcgcagcc ttgctgtctg tgaggaatct tctgccagac caggaggtga aagtcttcag      480

gatcaggaat caattcattt acagctttcc agtttttcca gcctgcaaga ggaggataaa      540

tctaggaaag atgactctga aagagaaaaa gaaaaggata aaaacaaaga taaaacctct      600

gaaaaaccca agatcagaat gttatcaaaa gattgcagcc aagaatacac ggattctaca      660

ggcatagact tacacgagtt tctgattaac acattaaaga ataattccag ggacaggatg      720

atacttttga aaatggagca ggaaattatt gatttcattg ctgacaacaa taatcattat      780

aaaaagttcc ctcagatgtc atcgtatcag aggatgcttg tccatcgagt ggcagcttat      840

tttggattgg atcacaatgt ggatcaaaca ggaaaatctg ttatcatcaa caagaccagc      900

agcaccagaa taccagagca aaggttttgt gaacatttaa aagatgaaaa aggtgaagaa      960

tcccagaagc ggtttatctt gaagcgagat aactctagta ttgataaaga agacaatcag     1020

tcagtttgct cccaggaaag cctttttgtg gaaaacagta ggctcttgga agacagtaac     1080

atatgcaatg agacctataa gaaaagacag ctctttcggg gcaacagaga tggctcaggg     1140

agaacatctg ggagtcgaca gagcagctca gaaaatgaac tcaagtggtc tgaccaccaa     1200

agggcctgga gcagcacaga ctccgacagt tccaaccgca atctaaagcc cgccatgacc     1260

aagacggcga gttttggggg catcacggtg ctgaccaggg gtgacagcac ttccagtact     1320

aggagtaccg ggaagctgtc caaagcaggt tccgagtctt ccagcagtgc aggctcctca     1380

ggatcgctgt cccgcaccca tccacctctc cagagcacac ccctagtctc aggtgtggca     1440

gctggctctc caggctgtgt gccttatcca gagaatggaa tagggggcca ggttgctccc     1500

agcagcacca gctacatcct ccttccactt gaagctgcaa caggcatccc gcctggaagc     1560

atccttctta atccacacac aggccagccc tttgtgaatc ccgatggaac tcctgcaata     1620

tacaacccac ccaccagtca gcagcccctg cgaagcgcca tggtggggca gtcccaacag     1680

cagccaccac agcagcagcc ctccccgcag ccccaacagc aggtccagcc accgcagcca     1740

cagatggcag gccctctggt cactcagtct gtccaggggc tgcaggcttc ctcccagtca     1800

gtgcaatatc cagcagtctc ttttcctccc cagcacctcc tacctgtgtc tccaacgcag     1860

cactttccca tgagagatga tgtggcaaca cagtttggcc agatgaccct gagccggcag     1920

tcctcggggg agactcctga acccccatca ggtcctgtct acccatcctc ccttatgcca     1980

cagccggccc agcagcccag ctatgtaatc gcctctacag gccagcagct tcctacagga     2040

ggattctcag gctctggccc tcccatctcc cagcaggtcc tccagccccc tccctcacca     2100

cagggatttg tgcaacagcc tccgcctgca cagatgcctg tatattatta cccatctggt     2160

cagtacccta cctcaaccac gcaacagtac cggcccatgg ccccggttca gtacaacgct     2220

cagaggagtc aacagatgcc acaggcagca cagcaagcag gttaccagcc agtcttgtct     2280

ggtcaacagg gattccaagg cctaatagga gtgcagcagc cacctcagag tcagaacgtg     2340

ataaataacc aacaaggaac tccggtgcaa agcgtgatgg tttcctaccc aacaatgtct     2400

tcttatcagg tgccaatgac ccagggttct caaggactgc cccagcagtc ataccaacag     2460

ccaatcatgc tacctaacca ggcaggtcaa gggtcactcc cagccactgg aatgcctgtt     2520

tactgtaatg tcacaccgcc cacccctcag aacaacctta ggctgattgg cccacactgc     2580

ccctccagca ctgtcccagt gatgtcagct agctgcagaa caaactgtgc aagtatgagc     2640

aatgctggtt ggcaggtcaa attctgagag ctctggctgt ggtacatttc ttcagatatt     2700

tctcatggcc tttgatggaa gaggaacaag gtgggaaaac tggctgagga cttaagtatt     2760

cactcaacac tcaaatgatt gctgctggta ttctgtaaaa aataaacaaa gactaatata     2820

cacgttagct ggttaatggt gcatatttct gtcatgtctg ctaggtatgc ctttatagct     2880

tagctagtga catgaattca tcaaggtaag attttctcct accactgaat accactgtgt     2940

agattataat atccctaatt tggattagtt ttgtactttg tgttgagttt gtgatgctaa     3000

aagtatttaa aaattatata ctaaatcaca ttgtaccaaa gctgtaatgg aaaagcaaag     3060

aagaattgat gaattgaagg aataatttat atacatt                              3097


<210> 3687
<211> 4829
<212> DNA
<213> Homo sapiens

<400> 3687
gtcacttccg gtcgacggcg gaaggcggaa ggcggagcgg tccctgcaac ccggccggcg       60

ggaactgcct tctagttttt agtctcagac cagaccaccg ggcgcacccc gatgccgagc      120

ccgcagcttc tggtgctctt cggcagccag acaggcacgg ctcaggatgt gtcggagaga      180

ctgggtcgcg aggcccggcg ccggcggctt ggctgccggg tgcaggccct ggactcctac      240

ccggtggtga atctgattaa cgagcccctg gtgatatttg tttgtgcaac tacaggccaa      300

ggagaccccc ctgacaacat gaagaacttc tggaggttta tattccggaa gaacctgccc      360

tccactgccc tctgtcagat ggactttgcc gtcctgggcc tcggggactc ctcatacgcc      420

aagttcaact tcgtggccaa gaagctgcac cgacggctac tgcagcttgg gggcagcgcc      480

ctcctgcccg tgtgcctggg cgatgaccag catgagctgg ggcccgacgc tgctgtggac      540

ccctggctgc gagacttgtg ggacagggtt ctggggctgt acccgccgcc tccgggcctc      600

actgagatcc ctcccggagt ccccctgccc tccaagttca ccctgctgtt cctccaagag      660

gcacccagca cgggctctga ggggcagcgg gtagctcacc ccggctctca ggagcccccg      720

tcagagtcga agcccttcct agcacccatg atctccaacc agagagtcac cggcccctcc      780

cacttccagg acgttcggct gattgagttt gacatcttgg gctctggcat cagctttgct      840

gctggtgatg tggtgctgat tcagccctcc aactcggctg cccatgtcca gcggttctgc      900

caggtgctgg gcctggaccc tgaccagctc ttcatgctgc agccgcggga gccagatgtc      960

tcctccccca cgaggctgcc ccagccctgc tccatgcggc acctcgtgtc ccactacctg     1020

gacatcgcca gcgtgcctcg ccgctccttc ttcgaactcc tggcctgtct atccctccat     1080

gagctggagc gggagaagct gctggagttc agttctgccc aaggccagga ggagctcttt     1140

gaatactgca accggccccg caggaccatc ctggaggtgc tctgtgactt cccgcacaca     1200

gctgccgcca tccctcccga ctacctgttg gacctcatcc ccgttatccg gccgagggcc     1260

ttctccatcg cctcctcgct gctgatcctc gtggctgtag tgcagttcca gactcgcctc     1320

aaggagcccc gccggggcct ctgctcctcc tggctggcat ccctggaccc tgggcaagga     1380

cctgtccggg tgcccctctg ggtgcggcct gggagtctgg ccttcccaga gacaccagac     1440

acacctgtga tcatggtggg gcctggcact ggggtagccc ccttccgagc agccatccag     1500

gagcgtgtgg cccagggcca gactggaaac ttcttgtttt ttggctgccg ctggcgggac     1560

caagacttct actgggaggc tgagtggcag gagctggaga agcgggactg tctgaccctc     1620

atccctgcct tctcccggga acaggagcag aaagtatatg tgcagcaccg gctccgggag     1680

ctggggtcgc ttgtgtggga actgctggac cgccagggtg catacttcta cctggcaggc     1740

aacgccaagt ccatgccagc ggacgtctcg gaagccctga tgtccatctt ccaggaggag     1800

ggtggactct gcagcccgga cgcagccgcg tatctagcca ggctccagca gacacggcgc     1860

ttccagacag agacgtgggc ctgaggcccg cggctgcccg tgccccctct gacagccatc     1920

ctcctgggag cccaggaagg catccacgag ggagctcctg gccagcagcc gtcatcctct     1980

cggaccagcc agctggtcct ctgggaacag ccagctcccg agcacagccg cactcctgtt     2040

gaccctggat cccacccttt gagcctgacc ccactgcagc ctctgcccag ccagccctgc     2100

gctcccccac cctgacagtg agctgtgtcc tcgtcccccc acccccttcc cagtcaaggt     2160

ggtggcctgg gccgctccac ctcaccggtg cagtgaccca ggacggcatc agcagcccag     2220

tgagcaccag gggtggcata gggcacccat gaggctgcgc tgcactcctc tgccctgggg     2280

ccacctcggc tgctgcagcc tgcccagcag cacattccag tcactgcccc cgcactccca     2340

cagggctcag gctgggctca gaggccactg agatgccagc tccttgagag cagtgggggt     2400

gtcccaggcc agagcagcct cttcctctcc tggtcccaga aaaacccttg cagtaaatgg     2460

tggcctctgg gtggttactt ctagcgcagg cttccttcct tcctctagct cctcccggtg     2520

ccctgggtgc tgggtgctgg atggatgggc gtcctctagc tcctcccggt gccctgggtg     2580

ctgggtgctg gatgggtggg cgtcctctag ctcctcccgg tgccctgggt gctgggtgct     2640

ggatgggtgg gcgccacggt gcacccttgt tgggctgcct gtgcccgagt ggcctctgca     2700

gctcttatgt ctgcctctaa tgggatgtgc gccctgactg cctcgttctt aagggcatag     2760

tgggtcggct aagatctgat cgccaggact gcgttctggg caggtgctgg gaaggcggaa     2820

ccaagccgtc cgtgccgcta gggagccgag actgccggaa agaggagcgg caggaggggg     2880

cgtggttgtg cagccccacc cccgggaggg gctttaggca ctgggaagga aagtcctgtt     2940

ggaggagttc ggtggctgtt cacacccgcc tcgctgtctt ggagtcttga tctgtcgtcg     3000

gcgggtcgct ggcacaggac taaacatggc tgaggctggg ctccagccag atctggctgg     3060

ggacagcacc gcgtgggccc aggatccacc cagagcaggc aggccttgct ggggccccag     3120

tcaagtccac ttccagtgag gagagccagc cgggaggtca gtgccagagc tctggtggag     3180

cccagaccct gccttccctg agggccgccc ctgtcgccgc cctggggtcc ctgtcctcct     3240

atcctgactc ctgccccagg gccaccaccc ctgaactgtg ccctggggcc cccaccctcc     3300

acctggccga ctccagctct gggcctgtca gtccacctgg gtcctctctg ggccctgagt     3360

gcctggaccc tctgtgccaa gcaccagcaa gcaaagggga tgaccttggg cacccccaag     3420

gtgctgagac tacagccagt gagcccctgc tgggggccaa agccatggag ggtgcctggg     3480

cccttccaac ctggaaggag gaggggagag agcaggcagc agggcagggg gaagaggagg     3540

agtgcccgat ctgcacagag ccctacgggc ccagagagcg ccgcctggcc ctgctgaact     3600

gtagccacgg cctgtgtgtg ggctgcctgc acaggctgct gggctcggcc tccagtgccg     3660

acctgggccg ggtgcgctgc ccgctgtgcc gccagaagac gcccgtgctg gaatgggaga     3720

tctgccggct acaggaggag ctgctacagg ccgacgggcc ctcacgccag ccccgccgag     3780

aggcccctgc atcctatcac cgcaaccctg ggccctgggg ctccctggag caccgctacc     3840

agctgcgctt cctggcaggg cccgtgggcg gccggggctg cctgcccttc ctgccctgtc     3900

caccctgcct gggtgcccgg ctctggaccc tgcgggagcg gggaccctgt gcccgccgcc     3960

tggcgctgct gagcctgctg gcccttgagc ttctggggct gctgctggtc ttcacgccgc     4020

tcctgctgct gggactgctc ttcgtgctcc tggaccgctc tggccgctga gcagagccca     4080

ggacagcccc gccgccaaca ggccaggggg cccagactgg cccacgtccc catgcctggg     4140

tgctgtgagg cctgatgacc aggctggaaa aacccaaggt tgggtccagg gcaggggcct     4200

tcaatcaaga cctcccattg ctgaacccac aaccagggct acccagaggc ctgaccctgc     4260

cagagtccat ggctgcactg ctgcccagac actagctgaa cccaaggaca ccagcgccca     4320

aggacagctc ctggaggagg ccagcccagc aggaaagtct gtgagcagga ccccattcac     4380

cctgcggcag acgggcaccg tactggccac gggctgacgc cggccacact tcccctccga     4440

gggccagctg agcacagcag gcatgaaagc aaacagagat acagcagtga gtcagttcct     4500

tggagagggc agggactccg cccaccctgt gttcagataa gggccagtgt gtgtccctga     4560

aggtcaggcc agccggggga ggggtccatg ctgcgaaaat tcagcctgca aaggctcctc     4620

tccccacttg atcaggccca gaccaggtgg gggttggcgc tggcctgtgt tgcaggggac     4680

aagggcccac ccaggccttg gaacataagc tctgcccctg cacaccctca tgtcaccaca     4740

cctgggatgg agacatcagg tggcccagcg agagatggag gactgatcct ggaacgtgaa     4800

gcagctttca ataaaccagc tcctgggga                                       4829


<210> 3688
<211> 3066
<212> DNA
<213> Homo sapiens

<400> 3688
gatgctgttt ggcgactcgt cgccattccc ggagcaggtc ggcctcggcc caggggcgag       60

tatccgttgc tgtgtcggag acactagtcc ccgacaccga gacagccagc cctctcccct      120

gcctcgcggc gggagagcgt gtccggccgg ccggccggcg gggctcgcgc aacctccctc      180

gcctcccctt cccccgcagc ctccgtcgcc gctgccgccg ggcttaacag ccccgtccgc      240

cgcttctctt cctagtttga gaagccaagg aaggaaacag ggaaaaatgt cgccatgaag      300

gccgagaacc gctgccgccg ccgacccccg ccggccctga acgccatgag cctgggtccc      360

cgccgcgccc gctccgctcc gactgccgtc gccgccgagg cccccgttga tgccgctgag      420

ctcccccaac gccgccgcca ccgcctccga catggacaag aacagcggct ccaacagctc      480

ctccgcctct tcgggcagca gcaaagggca acagccgccc cgctccgcct cggcggggcc      540

agccggcgag tctaaaccca agagcgatgg aaagaactcc agtggatcca agcgttataa      600

tcgcaaacgt gaactttcct accccaaaaa tgaaagtttt aacaaccagt cccgtcgctc      660

cagttcacag aaaagcaaga cttttaacaa gatgcctcct caaaggggcg gcggcagcag      720

caaactcttt agctcttctt ttaatggtgg aagacgagat gaggtagcag aggctcaacg      780

ggcagagttt agccctgccc agttctctgg tcctaagaag atcaacctga accacttgtt      840

gaatttcact tttgaacccc gtggccagac gggtcacttt gaaggcagtg gacatggtag      900

ctggggaaag aggaacaagt ggggacataa gccttttaac aaggaactct ttttacaggc      960

caactgccaa tttgtggtgt ctgaagacca agactacaca gctcattttg ctgatcctga     1020

tacattagtt aactgggact ttgtggaaca agtgcgcatt tgtagccatg aagtgccatc     1080

ttgcccaata tgcctctatc cacctactgc agccaagata acccgttgtg gacacatctt     1140

ctgctgggca tgcatcctgc actatctttc actgagtgag aagacgtgga gtaaatgtcc     1200

catctgttac agttctgtgc ataagaagga tctcaagagt gttgttgcca cagagtcaca     1260

tcagtatgtt gttggtgata ccattacgat gcagctgatg aagagggaga aaggggtgtt     1320

ggtggctttg cccaaatcca aatggatgaa tgtagaccat cccattcatc taggagatga     1380

acagcacagc cagtactcca agttgctgct ggcctctaag gagcaggtgc tgcaccgggt     1440

agttctggag gagaaagtag cactagagca gcagctggca gaggagaagc acactcccga     1500

gtcctgcttt attgaggcag ctatccagga gctcaagact cgggaagagg ctctgtcggg     1560

attggccgga agcagaaggg aggtcactgg tgttgtggct gctctggaac aactggtgct     1620

gatggctccc ttggcgaagg agtctgtttt tcaacccagg aagggtgtgc tggagtatct     1680

gtctgccttc gatgaagaaa ccacggaagt ttgttctctg gacactcctt ctagacctct     1740

tgctctccct ctggtagaag aggaggaagc agtgtctgaa ccagagcctg aggggttgcc     1800

agaggcctgt gatgacttgg agttagcaga tgacaatctt aaagagggga ccatttgcac     1860

tgagtccagc cagcaggaac ccatcaccaa gtcaggcttc acacgcctca gcagctctcc     1920

ttgttactac ttttaccaag cggaagatgg acagcatatg ttcctgcacc ctgtgaatgt     1980

gcgctgcctc gtgcgggagt acggcagcct ggagaggagc cccgagaaga tctcagcaac     2040

tgtggtggag attgctggct actccatgtc tgaggatgtt cgacagcgtc acagatatct     2100

ctctcacttg ccactcacct gtgagttcag catctgtgaa ctggctttgc aacctcctgt     2160

ggtctctaag gaaaccctag agatgttctc agatgacatt gagaagagga aacgtcagcg     2220

ccaaaagaag gctcgggagg aacgccgccg agagcgcagg attgagatag aggagaacaa     2280

gaaacagggc aagtacccag aagtccacat tcccctcgag aatctacagc agtttcctgc     2340

cttcaattct tatacctgct cctctgattc tgctttgggt cccaccagca ccgagggcca     2400

tggggccctc tccatttctc ctctcagcag aagtccaggt tcccatgcag actttctgct     2460

gacccctctg tcacccactg ccagtcaggg cagtccctca ttctgcgttg ggagtctgga     2520

agaagactct cccttccctt cctttgccca gatgctgagg gttggaaaag caaaagcaga     2580

tgtgtggccc aaaactgctc caaagaaaga tgagaacagc ttagttcctc ctgcccctgt     2640

ggacagcgac ggggagagtg ataattcaga ccgtgttcct gtgcccagtt ttcaaaattc     2700

cttcagccaa gctattgaag cagccttcat gaaactggac acaccagcta cttcagatcc     2760

cctctctgaa gagaaaggag gaaagaaaag aaaaaaacag aaacagaagc tcctgttcag     2820

cacctcagtc gtccacacca agtgacacta ctggcccagg ctaccttctc catctggttt     2880

ttgtttttgt ttttttttcc cccatgcttt tgtttggctg ctgtaatttt taagtatttg     2940

agtttgaaca gattagctct ggggggaggg ggtttccaca atgtgagggg gaaccaagaa     3000

aattttaaat acagtgtatt ttccagcttc ctgtctttac accaaaataa agtattgaca     3060

caagag                                                                3066


<210> 3689
<211> 2571
<212> DNA
<213> Homo sapiens

<400> 3689
accgcaggcg ggcctcgcgg gtccgggagc gcggcggaga cgatgcctga gatcagagtc       60

acgcccttgg gtgcctgccc tgtgctgtcc tggaacctgg tccttccacc gggcaggggg      120

tcgagggcac cttccagcac agacaccagg acgggattcc atgtcctccc ccatggcgtg      180

agcgcttcct cggagggtgc cccccgcccc ggtgtggaca ctgtgctgtg aacacccctg      240

gcctgtgcac accccatggc attttgcagc tgtttgcatg ggccccactg ccctcccctg      300

ctctctgggt cctccgtggg gtcctcccag cctgcccctt tcccatttgg cctcttggct      360

gcctgttctg cccactctct ggacatctga tctttctgat ctttcatgtg gcttcaatta      420

cccgcaatct gtacctgggt atattctcaa ggtcacctca gccaaggcag cccctcggct      480

gtggccccgt catcctgatg tgtggtgctg gctttggaca cttcgagtgg ctggcagggg      540

gaggggccgg ccaggacgtg ggccgaagct gcatcctggt ctccattgcg ggcaagaatg      600

tcatgctgga ctgtggaatg cacatgggct tcaatgacga ccgacgcttc cctgacttct      660

cctacatcac ccagaacggc cgcctaacag acttcctgga ctgtgtgatc attagccact      720

tccacctgga ccactgcggg gcactcccct acttcagcga gatggtgggc tacgacgggc      780

ccatctacat gactcacccc acccaggcca tctgccccat cttgctggag gactaccgca      840

agatcgccgt agacaagaag ggcgaggcca acttcttcac ctcccagatg atcaaagact      900

gcatgaagaa ggtggtggct gtccacctcc accagacggt ccaggtagat gatgagctgg      960

agatcaaggc ctactatgca ggccacgtgc tgggggcagc catgttccag attaaagtgg     1020

gctcagagtc tgtggtctac acgggtgatt ataacatgac cccagaccga cacttaggag     1080

ctgcctggat tgacaagtgc cgccccaacc tgctcatcac agagtccacg tacgccacga     1140

ccatccgtga ctccaagcgc tgccgggagc gagacttcct gaagaaagtc cacgagaccg     1200

tggagcgtgg tgggaaggtg ctgatacctg tgttcgcgct gggccgcgcc caggagctct     1260

gcatcctcct ggagaccttc tgggagcgca tgaacctgaa ggtgcccatc tacttctcca     1320

cggggctgac cgagaaggcc aaccactact acaagctgtt catcccctgg accaaccaga     1380

agatccgcaa gactttcgtg cagaggaaca tgtttgagtt caagcacatc aaggccttcg     1440

accgggcttt tgctgacaac ccaggaccga tggttgtgtt tgccacgcca ggaatgctgc     1500

acgctgggca gtccctgcag atcttccgga aatgggccgg aaacgaaaag aacatggtca     1560

tcatgcccgg ctactgcgtg cagggcaccg tcggccacaa gatcctcagc gggcagcgga     1620

agctcgagat ggaggggcgg caggtgctgg aggtcaagat gcaggtggag tacatgtcat     1680

tcagcgcaca cgcggacgcc aagggcatca tgcagctggt gggccaggca gagccggaga     1740

gcgtgctgct ggtgcatggc gaggccaaga agatggagtt cctgaagcag aagatcgagc     1800

aggagctccg ggtcaactgc tacatgccgg ccaatggcga gacggtgacg ctgcccacaa     1860

gccccagcat ccccgtaggc atctcgctgg ggctgctgaa gcgggagatg gcgcaggggc     1920

tgctccctga ggccaagaag cctcggctcc tgcacggcac cctgatcatg aaggacagca     1980

acttccggct ggtgtcctca gagcaagccc tcaaagagct gggtctggct gagcaccagc     2040

tgcgcttcac ctgccgcgtg cacctgcatg acacacgcaa ggagcaggag acggcattgc     2100

gcgtctacag ccacctcaag agcgtcctga aggaccactg tgtgcagcac ctcccagacg     2160

gctctgtgac tgtggagtcc gtcctcctcc aggccgccgc cccttctgag gacccaggca     2220

ccaaggtgct gctggtctcc tggacctacc aggacgagga gctggggagc ttcctcacat     2280

ctctgctgaa gaagggcctc ccccaggccc ccagctgagg ccggcaactc acccagccgc     2340

cacctctgcc ctctcccagc tggacagacc ctgggcctgc acttcaggac tgtgggtgcc     2400

ctgggtgaac agaccctgca ggtcccatcc ctggggacag aggccttgtg tcacctgcct     2460

gcccaggcag ctgtttgcag ctgaagaaac aaactggtct ccaggctgtc ttgcctttat     2520

tcctggttag ggcaggtggt cctagacagc agtttccagt aaaagctgaa c              2571


<210> 3690
<211> 1251
<212> DNA
<213> Homo sapiens

<400> 3690
ggcaagagcg gcagccacac cggcagattg cagaccgggc aaggtccccc aggccaggat       60

gtcaggcctg gtgttggggc agcgggatga gcctgcaggc caccggctca gccaagagga      120

gatcctgggg agcacacggc tggtcagcca agggctagag gccctacgca gtgaacacca      180

ggccgtgctg caaagcctgt cccagaccat tgagtgtctg cagcagggag gccatgagga      240

agggctggtg catgagaagg cccggcagct tcgccgttct atggaaaaca ttgagctcgg      300

gctgagtgag gcccaggtga tgctggctct agccagccac ctgagcacag tggagtcgga      360

gaaacagaag ctgcgggctc aggtgcggcg gctatgccag gagaaccagt ggctgcggga      420

tgagctggct ggcacccagc agcggctaca gcgcagtgaa caggctgtgg ctcagctgga      480

ggaggaaaag aagcacctgg agttcctggg gcagctgcgg cagtatgatg aggatggaca      540

tacctcggag gagaaagaag gcgatgccac caaggattcc ctggatgacc tctttcctaa      600

tgaggaggaa gaggacccca gcaatggctt gtcccgtggt caaggtgcta cagcagctca      660

gcagggtgga tatgagatcc cagcaaggtt gcggacgttg cacaacctgg tgatccagta      720

cgcagcccaa ggtcgctatg aggtggccgt gccactctgt aagcaggcac tagaggacct      780

ggagcgcaca tcaggccgtg gccaccctga tgtcgccacc atgctcaaca tccttgcttt      840

ggtgtatcgt gaccagaata agtataagga agctgcccac ctgctgaatg atgcccttag      900

catccgggag agcaccttgg gacctgacca tcctgctgtc agtattcctt gccctcccca      960

ccccacgccc cgcacccccc accattgctg ttttggcctc tcttagctca tccatctgct     1020

gccctcagtc cactcactaa gggtgctgag gaaggaggca taagaagtcc tttcttccag     1080

gcactgtcca gtgatcctaa tgattctcaa ttctctgaga ctcagtgact cctttttata     1140

acaaatattt tgcttgaatt taattaatag ataagtcata ggtaaatcca catatgattt     1200

ctacaaaact taatatgcta ctctaataaa tataaaagaa aaacaagaaa a              1251


<210> 3691
<211> 4210
<212> DNA
<213> Homo sapiens

<400> 3691
ggtttcaaat tggccctttg gcctctggag caaattcaaa tgtaactctt ccccaacccc       60

ccttctcttc ttccagatta attaaaagaa gaatgaacta taatccttga agataactgg      120

gcaatttttt aagtcggagg ctgttcttac tggtgtgagg atttacacac gtcttcagtt      180

tttcagcaca gaccagcaga ccatcatttt tagaggaaat actccctctg ccctcctttt      240

tggtttcctt ggtggtaaag attaaatttg gttgcatcat tttgacttgt gtttgagtct      300

agattttatg gcacaaggaa tggcataaac ttttcatgtg ttttggttaa aacaaaccag      360

accattgcat tgaccctgga catctttaat tgagaaattg gtaactttat tttaatatgt      420

atatctgaag aattcaagaa aacaaaggca tcctcagagg tgtgcctctt ttctttatta      480

ttagaggcaa aacgaacaat tttataggat ttgtagtgaa attataccag attataagga      540

gaaccaaaac taagtcgcaa aatttattaa tttaaggggc tctcgctttg aaagtttgag      600

agtaagttac gataggcatt tgtatccatt cattactttc ctcttttcaa ataagcaact      660

aaatagaaat gctaatctca gacttaatta tttaacagaa gagtgtacca tggaaaacct      720

ccagacaaat ttctccttgg ttcagggctc aactaaaaaa ctgaatggga tgggagatga      780

tggcagcccc ccagcgaaaa aaatgataac ggacattcat gcaaatggaa aaacgataaa      840

caaggtgcca acagttaaga aggaacactt ggatgactat ggagaagcac cagtggaaac      900

tgatggagag catgttaagc gaacctgtac ttctgttcct gaaactttgc atttaaatcc      960

cagtttgaaa cacacattgg cacaattcca tttaagtagt cagagctcgc tgggtggacc     1020

agcagcattt tctgctcggc attcccaaga aagcatgtcg cctactgtat ttctgcctct     1080

tccatcacct caggttcttc ctggcccatt gctcatccct tcagatagct ccacagaact     1140

cactcagact gtgttggaag gggaatctat ttcttgtttt caagttggag gagaaaagag     1200

actctgtttg ccccaagtct taaattctgt tctccgagaa tttacactcc agcaaataaa     1260

tacagtgtgt gatgaactgt acatatattg ttcaaggtgt acttcagacc agcttcatat     1320

cttaaaggta ctgggcatac ttccattcaa tgccccatcc tgtgggctga ttacattaac     1380

tgatgcacaa agattatgta atgctttatt gcggccacga acttttcctc aaaatggtag     1440

cgtacttcct gctaaaagct cattggccca gttaaaggaa actggcagtg cctttgaagt     1500

ggagcatgaa tgcctaggca aatgtcaggg tttatttgca ccccagtttt atgttcagcc     1560

tgatgctccg tgtattcaat gtctggagtg ttgtggaatg tttgcacccc agacgtttgt     1620

gatgcattct cacagatcac ctgacaaaag aacttgccac tggggctttg aatcagctaa     1680

atggcattgc tatcttcatg tgaaccaaaa atacttagga acacctgaag aaaagaaact     1740

gaagataatt ttagaagaaa tgaaggagaa gtttagcatg agaagtggaa agagaaatca     1800

atccaagaca gatgcaccat caggaatgga attacagtca tggtatcctg ttataaagca     1860

ggaaggtgac catgtttctc agacacattc atttttacac cccagctact acttatacat     1920

gtgtgataaa gtggttgccc caaatgtgtc acttacttct gctgtatccc agtctaaaga     1980

gctcacaaag acagaggcaa gtaagtccat atcaagacag tcagagaagg ctcacagtag     2040

tggtaaactt caaaaaacag tgtcttatcc agatgtctca cttgaggaac aggagaaaat     2100

ggatttaaaa acaagtagag aattatgtag ccgtttagat gcatcaatct caaataattc     2160

tacaagtaaa aggaaatctg agtctgccac ttgcaactta gtcagagaca taaacaaagt     2220

gggaattggc cttgttgctg ccgcttcatc tccgcttctt gtgaaagatg tcatttgtga     2280

ggatgataag ggaaaaatca tggaagaagt aatgagaact tatttaaaac aacaggaaaa     2340

actaaacttg attttgcaaa agaagcaaca acttcagatg gaagtaaaaa tgttgagtag     2400

ttcaaaatct atgaaggaac tcactgaaga acagcagaat ttacagaaag agcttgaatc     2460

tttgcagaat gaacatgctc aaagaatgga agaattttat gttgaacaga aagacttaga     2520

gaaaaaattg gagcagataa tgaagcaaaa atgtacctgt gactcaaatt tagaaaaaga     2580

caaagaggct gaatatgcag gacagttggc agaactgagg cagagattgg accatgctga     2640

ggccgatagg caagaactcc aagatgaact cagacaggaa cgggaagcaa gacagaagtt     2700

agagatgatg ataaaagagc taaagctgca aattctgaaa tcatcaaaga ctgctaaaga     2760

atagaaactg ttaaagagat tcatctgtgt attactgaca aggttttttt tgtttgttgc     2820

ttgctttggt aattgaattc tgaagaattt atctgcatga cgataactag gcattctatc     2880

catttgtaga tcagagaaag tgaagagatt atatattagt acttaaattt ttacattttc     2940

caaatgaatg aaaatgtatg tttctttgta cttttttaaa aaaatcagct tagtaacaat     3000

actatatggt ttcaactagt aggtaatctg cttatatttc taatgcaaac ttaacaattg     3060

tgtacttttt aaaagctgca atatgtgttg gaaaatagct gtggtcaatt ttgttatcca     3120

tatttcagac tcaattttag atacaatggt ggctttatat tttaagtata tagagctact     3180

caaggagttg aatctcccct tttctcatta acacaatttt tctaagttga tatggtgtac     3240

tcattaacat acaccaaatt tacttttact ttgttcagat tgtggaatga atttccacca     3300

gttctcttct ttttaatgtg taccctagga ggaattttac tgaggttata gcatacccca     3360

tgagcacagt ggggaagaag aatgtgttgt tatgtgctgc tgctaaacag aagcagcagt     3420

tgtaatttgt ttttcagttt aaatgtggtt atagttagat ttttttttaa gcagcaactt     3480

ttcaaaaata aaatgtgata atttctgaac ttttgtttgt gttgttaata gtggtgtgaa     3540

aatattaacg ttcttgagaa aaactgatac cactgttgtg tatcagtttc tatacaatcc     3600

ataatcctcc tgtacagttt ttacatgtag ttatgagtct tactaaaatt tatataatgg     3660

acttgttttc ctttaagttg taaaatgtta aacaccttga aggttatttt ggacttctgt     3720

atgtttaaat gttgtcttac caaaatttgc acgaatggac cattttcatt tactacttaa     3780

tatcaaaatc aggaatttac agtcaactga tagtacatga taggtgcata taggacagtt     3840

tagttacctg ctactaaaag atttttagat aagttttaga agataaagga attccatagt     3900

ttcaggaggg acaacatctt ctgcactttt tttttgcaca gaaaagtctg tcattctcta     3960

atggcaaatt tcatatttgt taattcttgg ctcaaaatat attaggtaaa attcttagat     4020

ctgtttttaa agggagtttc ctgaaactat cattaattga cattattacc ccatggattt     4080

tatgggataa taaatgtttt tcatgttctc ttataagata ctatgtatga aattacttca     4140

gagagctata tttattttaa aataaattag ctagggttaa ggttatattc tatttccagc     4200

atagaaggta                                                            4210


<210> 3692
<211> 5971
<212> DNA
<213> Homo sapiens

<400> 3692
agagcctcgg tggtttgcag cagtggaacc aggcaggccc agttgtgggt aggagaggcc       60

gtcacctgtt gaggcctccc ccccacaccc ccgcatcgcc ctgccctggc agagcccagc      120

ccccagtccc cggagagcgc gcctgaggac ggacggacgg acggacggac agacctaggg      180

acggagggcc aggggcaggg gagatccaag aggccccgcg ctggaatgca gttttctcgg      240

gcgagggaga ctttgcaccg gagtggaaaa tagtttgggg tggggtttcg caccgtcccc      300

tcctccccag ccccgggccc cctcccaggc gctttctggg agcttttaga actgcgctct      360

gaagtttcca gagagcgagg agcttttgcg gcaggcagag acaatggaag aaaatgaaag      420

ccagaaatgt gagccgtgcc ttccttactc agcagacaga agacagatgc aggaacaagg      480

caaaggcaat ctgcatgtaa catcaccaga agatgcagaa tgccgcagaa ccaaggaacg      540

cctttctaat ggaaacagtc gtggttcagt ttccaagtct tcccgcaata tcccaaggag      600

acacacccta ggggggcccc gaagttccaa ggaaatactg ggaatgcaaa catctgagat      660

ggatcggaag agagaagcgt tcctagaaca tctgaagcag aagtaccccc accacgcctc      720

tgcaatcatg ggtcaccaag agaggctgag agaccagaca aggagcccca aactgtctca      780

cagtcctcaa ccacccagtc tgggtgaccc ggtcgagcat ttatcagaga cgtccgctga      840

ttctttggaa gccatgtctg agggggatgc tccaacccct ttttccagag gcagccggac      900

tcgtgcgagc cttcctgtgg tgaggtcaac caaccagacg aaagaaagat ctctgggggt      960

tctctatctc cagtatggag atgaaaccaa gcagctcagg atgccgaatg aaatcacaag     1020

tgcagacaca atccgtgctc tcttcgtaag tgcctttcca cagcagctca ccatgaaaat     1080

gctggaatcg cccagtgtcg ccatttacat caaagatgaa agcagaaatg tctattatga     1140

attaaatgat gtaaggaaca ttcaagacag atcactcctc aaagtgtaca acaaggatcc     1200

tgcacatgcg tttaatcaca caccaaaaac tatgaatgga gacatgagga tgcagagaga     1260

acttgtttat gcaagaggag atggccctgg ggcccctcgc cccggatcta ctgctcatcc     1320

accccatgcg attccaaatt ccccaccgtc tactccagtg ccccattcca tgcccccctc     1380

cccgtccaga attccttatg ggggcacccg ctccatggtt gttcctggca atgccaccat     1440

ccccagggac agaatctcca gcctgccagt ctccagaccc atctctccaa gcccaagcgc     1500

cattttagaa agaagagatg tcaagcctga tgaagacatg agtggcaaaa acattgcaat     1560

gtacagaaat gagggtttct atgctgatcc ttacctttat cacgagggac ggatgagcat     1620

agcctcatcc catggtggac acccactgga tgtccccgac cacatcattg catatcaccg     1680

caccgccatc cggtcagcga gtgcttattg taacccctca atgcaagcgg aaatgcatat     1740

ggaacaatca ctgtacagac agaaatcaag gaaatatccg gatagccatt tgcctacact     1800

gggctccaaa acaccccctg cctctcctca cagagtcagt gacctgagga tgatagacat     1860

gcacgctcac tataatgccc acggcccccc tcacaccatg cagccagacc gggcctctcc     1920

gagccgccag gcctttaaaa aggagccagg caccttggtg tatatagaaa agccacggag     1980

cgctgcagga ttatccagcc ttgtagacct cggccctcct ctaatggaga agcaagtttt     2040

tgcctacagc acggcgacaa tacccaaaga cagagagacc agcgagaaaa tgatgaaaac     2100

cacagccaac aggaaccaca cagatagtgc aggaacgccc catgtgtctg gtgggaagat     2160

gctcagtgct ctggagtcca cggtgcctcc cagccagcct ccacctgtgg gcacctcagc     2220

catccacatg agcctgcttg agatgaggcg gagcgtggcg gaactcaggc tccagctcca     2280

gcagatgcgg cagctccagc tgcagaacca ggagttgctg agggcaatga tgaagaaggc     2340

cgagctggaa atcagtggca aagtgatgga aacaatgaag agactggagg atcccgtgca     2400

gcgacagcgc gtcctagtgg agcaagagag acaaaaatat cttcatgagg aagagaagat     2460

cgtcaagaag ttgtgcgagt tggaagactt tgttgaagac ttgaagaagg actccacggc     2520

agccagccga ttggttactc tgaaagacgt ggaagacggg gctttcctcc tgcgtcaagt     2580

gggagaggct gtagctaccc tgaaaggaga atttccaacc ttacaaaaca agatgcgagc     2640

catcctgcgc atagaagtgg aggccgtgcg gtttctgaag gaggagccac acaagctgga     2700

cagtctcctg aagcgtgtgc gcagcatgac agacgtcctg accatgctgc ggagacatgt     2760

cactgatggg ctcctgaaag gcacggacgc agcccaagcc gcacagtaca tggctatgga     2820

aaaggccaca gccgcagaag tcctgaagag tcaggaggag gcagcccaca cctccggcca     2880

gcccttccac agcacaggtg cccctggcga tgcgaagtcg gaagtggtgc ctttgtccgg     2940

catgatggtt cgccacgcgc agagctcccc tgtggtcatc cagccctccc agcactccgt     3000

ggccctgctg aaccctgctc agaacttgcc tcacgtggcc agctccccag ccgtccccca     3060

ggaagcaacc tccactctgc agatgtcgca ggctccgcag tccccacaga tacccatgaa     3120

tgggtctgcc atgcagagct tgttcattga agaaatccac agtgtgagtg ccaagaacag     3180

ggcagtgtct atcgagaaag cagaaaagaa atgggaggaa aaaaggcaaa atctggatca     3240

ctataatggg aaagagtttg agaagctcct agaagaagct caggccaata tcatgaagtc     3300

aataccaaat ctggagatgc cgccagccac aggcccactg ccaaggggag atgccccagt     3360

ggacaaggtg gaactttcag aagattctcc aaattcggaa caggacttgg aaaagctggg     3420

gggaaagtcg ccccctcctc ctccgccacc tcctcgtcga agctacctgc caggatcggg     3480

actcaccacc acgaggtcag gcgatgtggt ctacaccggc agaaaggaga acatcaccgc     3540

taaggcaagc agtgaagatg ctggaccaag cccacagacc agagctacaa aatatccagc     3600

agaggagcct gcttcagcct ggaccccatc cccaccgcct gtcaccacct cctcctcaaa     3660

ggatgaggag gaagaagaag aagaaggaga caaaataatg gcagaactcc aggcattcca     3720

gaagtgttcc tttatggatg taaattcaaa cagtcatgct gagccatccc gggctgacag     3780

tcacgttaaa gacactaggt cgggcgccac agtgccaccc aaggagaaga agggctccag     3840

cggggcccca cagacgagca ggatgcctgt ccccatgagt gccaagaaca gacccggaac     3900

cctggacaaa cccggcaagc agtccaaact gcaggatccc cgccaatatc gtcaggctaa     3960

tggaagtgct aagaaatctg gtggggactt taagcctact tccccctcct tacctgcttc     4020

taagattcca gccctttctc ccagctctgg gaaaagcagt tctctgccct cttctagtgg     4080

tgacagctct aacctcccta atccacctgc tactaaacca tcgattgctt ctaaccctct     4140

cagcccccaa acaggaccac ctgctcactc tgcctccctc atcccttctg tctctaatgg     4200

ctctttgaag tttcagagcc tcactcatac aggtaaaggt caccatcttt cattctcacc     4260

gcagagtcaa aatggccgag caccccctcc tttgtcattt tcctcctccc ctccttctcc     4320

tgcctcctcc gtctcactga atcaaggtgc caagggcacc aggaccatcc atactcccag     4380

cctcaccagc tacaaggcac agaatggaag ttcaagcaaa gccaccccat ccacagcaaa     4440

agaaacctct taaaggtcaa atcctattag gcacaagtcg gagttacatt taaaaaaaat     4500

taacagtcta caacaactgt tttcacaaga gaatgtaaca tattgctgta tcgtttgagg     4560

cttaatgcta aatatgtgct aaatactgga ttaatagatt tcagtaaagc tcgttcgttt     4620

tgtttggttt tctttttacc tagttgctat agtgtctaca gtctatactc aatacctata     4680

aaatgcagta agcatgtgtt acagaaagag gttctggtgg gagagaaagg tgcgtgtgag     4740

acaggagaat tgtcttaagc atataaaaca tgtatgattc cagaatttta gtatgttttg     4800

tataaaacta tttttcatta cggagactag aagtgaacag agaattacac aagtgtgact     4860

atacaaattg taaaacagat actataatat ttccttttat tttagtgtta tttagcttta     4920

ttacagattt ctatttttgt caaaacttca tggttccttt caagatcttt tttgccaaaa     4980

cattttgata ctatagcatt gtacatttga aagtagtgtt ctagactata aaaccaatga     5040

acttctacat gagccctaca gacaggcatg tgtagaaggc aatttatcaa acctattgca     5100

ctgccatgaa aagtgtgtat aataatttgc tagcccaagc aagctagttt tctttgcttg     5160

cttcttttct ttcttttttc cttccttttt tttttttttt tcttttttaa catgttgaga     5220

ttctctagtt gttttctttg gcgtatctaa ccccttcttt tgttttctga gacctggtaa     5280

cccacgctct tgcattgtgg attttaaaat gtatactctg tacggttctg taaaccgaaa     5340

aacttttgta aatatataaa tatacataga cataaaaata ctgtatgtga cagcacatag     5400

agtagttttc ccacaccaaa gttaattttt atgcatgctt taaaagtata tatcgggacc     5460

ggcagaaatg gaagtatcca tacattttta aaaagcaaca agtttgcaca gctagagtgt     5520

ttttgtaaat aaatgtattt gtataacaca gtcatgtaat atacagaact ataagcagag     5580

actttgcaaa actaaataaa gggctgcatg cttattattt tttgtacctt gtcactataa     5640

ctacttccta gtcaaagaac gaaatgtaac tgttaccgag ttaaatgttt ttccgctttg     5700

agggatgtaa ccacatccac tcagaggaca ctacttttct gaaagctctg gggtgactaa     5760

tgatgagttc ctaataaatt aattgcaagt gtggtgcctt ggatgtggcc tgttggctcg     5820

ctttcttctc tgtggcttat caaggtgtag atgacagaaa gcaaacctgg atacagagtt     5880

tccaccctca gttcctggag gggctcttat tattttctct ctttttaaaa aacttccagt     5940

agaagtaaag tggaaataaa atgtctttat c                                    5971


<210> 3693
<211> 1070
<212> DNA
<213> Homo sapiens

<400> 3693
aaataattca caagttggcc atgcagctga gacacattgg ggacaacatt gatcatagga       60

tggttcgaga ggatcttcaa caggatggca gagatgcact agatcatttt gtcttctttt      120

tctttagaag agttcaggtg ttgctgcatt ttttctggaa caaccatttg ctgtaaaagg      180

aaagtaaaga gaacctcgtc ctcaaactaa aggccacaga aatgggcact acctcctggc      240

ccactccctg ggcaccatgc cctctggtga cctgttggct ccactcttgt cactcatgtc      300

cagatctgca gtgccagctt ctccttctcg gtgacatgtc acctccctgc cccaatcctg      360

gctccaaccc tctctggaaa atcgaagtga aacatttgtc tctaatactc aaattcaaca      420

tatggctcat ctcatctacc ttcccatttc catgcctaga ggccccacta ctaccactag      480

caccgttggg tgtttccttc tcaggctctg attctacaac atttacgttc ttttctcacc      540

tttgatcccc tcactcctct gtgaccccct tcaagtcttc cttcaccact ccagtgtttt      600

cccataccac tcgaccctgc tcgaaggtat ctttccctgc tctgtcatcc tcttttaggc      660

atgcctgctt aaaatcggga gtgcttagtc cttggccaac agtcctgcct tctagaagaa      720

tgtaagacct gaaagagtta tgaatctatc actaggcaaa aacttctctt ttcctattgc      780

tggatggttt tgctattatt ggttggtggg ccctttgcct gtggaatgta tttcactcat      840

tctctcctgc acgctgttag gcagttcttt cacctgcatg cttcttcttt tacctttttg      900

tctacctcat agtccctctc tcccctcctt taaaagaatt ataaatatta ggaaagcttg      960

ttgttataaa ttaaaagttt acatatgtat cttgagttct tcatagggga agtgttattt     1020

taaaaaattc taaaaatgaa ataaatattg ttattttatt gagcatgaaa                1070


<210> 3694
<211> 544
<212> DNA
<213> Homo sapiens

<400> 3694
agaactgtgg gattgatgac ctcccacaac tggagcagcc gggaacagct ctgaccacac       60

agaggaaaga aattcctaag ggaacactgc tcagaaagta ctgcagcatg tcttcaaatg      120

cctgaggatc aagttggaaa actagaagca acagaaaaca caataagcgc aatggcggcg      180

gccgcggcgg agcagcaaca gttctacctg ctcctgggaa acctgctcag ccccgacaat      240

gtggtccgga aacaggcaga ggaaacctat gagaatatcc caggccagtc aaagatcaca      300

ttcctcttac aagccatcag aaatacaaca gctgctgaag aggctagaca aatggccgcc      360

gttctcctaa gacgtctctt gtcctctgca tttgatgaag tctatccagc acttccctct      420

gatgttcaga ctgccatcaa gagtgagcta ctcatgatta ttcagatgga aacacaatct      480

agcatgagga aaaaagtttg tgatattgcg gcagaactgg ccaggaattt aataggtgtg      540

tatg                                                                   544


<210> 3695
<211> 579
<212> DNA
<213> Homo sapiens

<400> 3695
agactcggtt ggtgactccg ggcgcgtcga agatcttgta cctgtcgttc gcagtggctc       60

actttcccag taatccataa gaacagcagg gataacaggg tcccatgtcg tttttttgtc      120

agaattcctc gactggcgac cctgtgcccg acaggctgca ccgcgcccgg cgcactgact      180

ccggcctctg cgcgcgcccc ctggccggct ccggggtggg gagggggctt cgcagatccc      240

cagaaaaccg cccggcgagc cacgagcccg tggactgcag gctccgcttc ctcgcggggt      300

gttcactttg tatcagtgtg ctgatttgcc gccagttaga agcaccttaa aaaggggccg      360

ggggccgtag gaggggggct tgtctgaagg aggctctggg cttgctgatc cacgcagcgg      420

tttgtcgcga ggctgcgggg gaacggccca cggccgcggt aacagggctt cgtcttcttt      480

gcagagccat gggcagcagg aagaaggaaa ttgccctgca ggtcaacatc agcacccaag      540

agctttggga ggaaatgctc agttccaaag gactaactg                             579


<210> 3696
<211> 1293
<212> DNA
<213> Homo sapiens

<400> 3696
acgcgcatgg aacgcagcga aggactatgg caggggagaa cttcgctacg ccgttccacg       60

ggcacgtggg ccgcggcgcc ttcagcgacg tgtacgagcc cgcggaggac acgtttctgc      120

ttttgaacgc gctggaggca gcggctgccg aactggcagg agtggaaata tgcctggaag      180

tagggtcagg gtctggtgta gtatctgcat tcctagcctc tatgataggc cctcaggctt      240

tgtacatgtg cactgatatc aaccctgagg cagcagcttg taccctagag acagcacgct      300

gtaacaaagt tcacattcaa ccagttatta cagatttggt caaaggcttg ctaccaagat      360

tgaccgaaaa agttgatctt ctggtgttta atccccccta tgtagtgact ccacctcaag      420

aggtaggaag tcacggaata gaggcagctt gggctggtgg caaaaatggt cgggaagtca      480

tggacaggtt ttttcccctg gttccagatc tcctttcacc aaaaggatta ttctatttag      540

ttaccattaa agaaaacaac ccagaagaaa ttttgaaaat aatgaagaca aaaggtctgc      600

aaggaaccac tgcactttcc agacaagcag gccaagaaac tctttcagtc ctcaagttca      660

ccaagtctta gcatacagtg tgtgcccaga actactggaa actgaatgca tttagcatat      720

tttgaaactg aagtcattca ttagatggat ttacatcact ggcttccctg gttctcaagc      780

ctttggattc agactgaatt ataccacagg ccttcctggg tctccagctt atagatgaca      840

gatcatggga cctcttagcc tccataatca tgtaagccac tttcttgtag tactggtaaa      900

agatatatta aaccaatcta taaaacagat agctatgaaa gagaaaggtg acaggcacaa      960

gcctaggcaa atagagaagg gttcctggac agcctctgac ttgcctaggt cattgtgcac     1020

acgtggcttg cctgaatgaa catgcccact gtgaaagatt ccatttctca acacatgtgc     1080

agtaagggaa ataaatcaat gtggctcaaa ctaaccgccc acacatgggg tggagccaca     1140

aggagtttgc tccttatgca ggggagaagc cgtgcctctt cagctcgtgt gtggtggcct     1200

ggcattcaat ttgtgaggtg taaaacctgc atgaaggacc cctctttttg tggagagctt     1260

tccttttgcc taataaattc tgccctcctc gcc                                  1293


<210> 3697
<211> 2958
<212> DNA
<213> Homo sapiens

<400> 3697
gctccaagtt gccgccagaa cccatggccg gcgtggaaac cgctgcgagg cggcgccacg       60

acggaggctg aggtcgccgg cagtatccat ggcgtcccag agcggcagct ccctggggct      120

cctggcctgg ttcttgcttc ttcagccatg gctcgaagag gcccgggcag gcagggtggg      180

tgcgcaggga ggcgtagcac tgctcttccc ctccgcgctc ccctcagggc caggcggcca      240

ggaccccgga gcgagcggat gggagccgcc acctgtaggg gctccaggat ccccagcggc      300

cccccagtcc agggggaacg cagtgcgccc cgcttcggtg ttacttccct caggtgagcc      360

ataccgaccc gaggaggatt ccagaatgac cccggcaagc ccagaagccc ggacgtctcc      420

tgtgcacccg aaattcccca aaattccaga aacttctgta gctccagggt ctccagcgac      480

cgcagggcct ccaggatcct gggttacttc agcatctaca gtgggagaag ccttggaatc      540

cgacggaatc tctgaccttg gaaggcagtt ttctcagggt attgtttctg gtgctagatc      600

tgtcctggcc tgcggggtag gtcaaagggg acacagcctg gctcagggag gttgagggtc      660

agaccctgac ctagatgatt tgagagagag gatagataac ccgcctccgc cctgggcagc      720

ctggtggggt ggtgggaagg tagtggcttc acttccagtc ccctctcttt actgagccca      780

ccagcctgtg gccaccgtgt ttcaaggatg attggaggat tgccagcccc aaacaagaag      840

tggccctggc aggtgagcct gcagaccagc aacatacacc actgcggagg ctccctcatc      900

gacaggcgct gggtgctcac tgccgcccac tgtgtcttta gtttcaggac caatgccact      960

tgttcttcag gagactgagc taaacattat gcgtcatgag aaatgttgtg agatgctcaa     1020

gaacaagaat atatccaaga gtaaaatggt cacgaggggg accgtctgtg gctataatga     1080

ccaagggaag gatgcctgtc aggttataaa gaggacacaa ccaatccagg ttgactctgg     1140

aagctccctt gtctgccaaa tggacaagac ctggattcag ataggagtgt tccttgggca     1200

aagccccact ggaggggctg gagggaaagt agggtcactt ggagatcctg gatgccagcc     1260

cctgaggttt ggtcttcatc tcactgcggg aggggtgaca ccatgagcca gtccagggca     1320

atgggctgcg agggtgagga ggtctgagaa tcggccgaga ttaagttgag ggactccagg     1380

agactgcttg gaccagcgga gtgaggagag ggaggggcca aggagggaag tcagccgggg     1440

cgtacccagc ccgggaggta taagggaggg ctgtcactag gggcgccctt gcgggtcaga     1500

caccacgagc gccgtggcgg gtggcccctg gggggcgcca cgcaggcggg gcactaggag     1560

catccccacc cagctcacca gaggccgcgg catgcggcca acagggggcg ccgtcgtggg     1620

ggcggcactg ggagcgcctt ccggagagac gcagtcggct gccaccccgg gatgggtcgc     1680

tggtgccaga ccgtcgcgcg cgggcagcgc ccccggacgt ctgccccctc ccgcgccggt     1740

gccctgctgc tgctgcttct gttgctgagg tctgcaggtt gctggggcgc aggggaagcc     1800

ccgggggcgc tgtccactgc tgatcccgcc gaccagagcg tccagtgtgt ccccaaggcc     1860

acctgtcctt ccagccggcc tcgccttctc tggcagaccc cgaccaccca gacactgccc     1920

tcgaccacca tggagaccca attcccagtt tctgaaggca aagtcgaccc ataccgctcc     1980

tgtggctttt cctacgagca ggaccccacc ctcagggacc cagaagccgt ggctcggcgg     2040

tggccctgga tggtcagcgt gcgggccaat ggcacacaca tctgtgccgg caccatcatt     2100

gcctcccagt gggtgctgac tgtggcccac tgcctgatct ggcgtgatgt tatctactca     2160

gtgagggtgg ggagtccgtg gattgaccag atgacgcaga ccgcctccga tgtcccggtg     2220

ctccaggtca tcatgcatag caggtaccgg gcccagcggt tctggtcctg ggtgggccag     2280

gccaacgaca tcggcctcct caagctcaag caggaactca agtacagcaa ttacgtgcgg     2340

cccatctgcc tgcctggcac ggactatgtg ttgaaggacc attcccgctg cactgtgacg     2400

ggctggggac tttccaaggc tgacggcatg tggcctcagt tccggaccat tcaggagaag     2460

gaagtcatca tcctgaacaa caaagagtgt gacaatttct accacaactt caccaaaatc     2520

cccactctgg ttcagatcat caagtcccag atgatgtgtg cggaggacac ccacagggag     2580

aagttctgct atgagctaac tggagagccc ttggtctgct ccatggaggg cacgtggtac     2640

ctggtgggat tggtgagctg gggtgcaggc tgccagaaga gcgaggcccc acccatctac     2700

ctacaggtct cctcctacca acactggatc tgggactgcc tcaacgggca ggccctggcc     2760

ctgccagccc catccaggac cctgctcctg gcactcccac tgcccctcag cctccttgct     2820

gccctctgac tctgtgtgcc ctccctcact tgtgggcccc ccttgcctcc gtgcccaggt     2880

tgctgtgggt gcagctgtca cagccctgag agtcagggtg gagatgaggt gctcaattaa     2940

acattactgt tttccatg                                                   2958


<210> 3698
<211> 550
<212> DNA
<213> Homo sapiens

<400> 3698
actgactcag tgacctcggg gtcgttaggc ctccacgtcc tcgctggagc tgcggacctc       60

agtcgtccat ccacacctcc cccctgccgc ccccgcccat ctcactctcc caaccctggg      120

caccagggca ggtcgacagc ccgaggcact cctctactgc gtttccaggc ccaggagacc      180

cactccagcg ccgcggttcc ttgcgacccg gcagccgttc agcagacctc ccattctttc      240

ctgcatcatc gggcattgtg gaggcaccct acgaccgggc aaggtccccc aggccaggat      300

gtcaggcctg gtgttggggc agcgggatga gcctgcaggc caccggctca gccaagagga      360

gatcctgggg agcacacggc tggtcagcca agggctagag gccctacgca gtgaacacca      420

ggccgtgctg caaagcctgt cccagaccat tgagtgtctg cagcagggag gccatgagga      480

agggctggtg catgagaagg cccggcagct tcgccgttct atggaaaaca ttgagctcgg      540

gctgagtgag                                                             550


<210> 3699
<211> 666
<212> DNA
<213> Homo sapiens

<400> 3699
ggcggagcga gtggaggctg cagcccagct cgtctcggcg cccgcgtcgc cgtcgcgaag       60

ccccccgccc cgcttccgcc gcgtcggaat gagctcccgg aaagtgctgg ccattcaggc      120

ccgaaagcgg aggccgaaaa gagagaaaca tccgaaaaaa aatcaagcag aagattgagc      180

tgctgatgtc agttaactct gagaagtcgt cctcttcaga aaggccggag cctcaacaga      240

aagctccttt agttcctcct cctccaccgc caccaccacc accaccgcca cctttgccag      300

accccacacc cccggagcca gaggaggaga tcctgggatc agatgatgag gagcaagagg      360

accctgcgga ctactgcaaa ggtggatatc atccagtgaa aattggagac ctcttcaatg      420

gccggtatca tgttattaga aagcttggat gggggcactt ctctactgtc tggctgtgct      480

gggatatgca ggggaaaaga tttgttgcaa tgaaagttgt aaaaagtgcc cagcattata      540

cggagacagc cttggatgaa ataaaattgc tcaaatgtgt tcgagaaagt gatcccagtg      600

acccaaacaa agacatggtg gtccagctca ttgacgactt caagatttca ggcatgaatg      660

ggatac                                                                 666


<210> 3700
<211> 604
<212> DNA
<213> Homo sapiens

<400> 3700
actttgttta tgggacagtc cgggagctgc tgcggccgcg ctgtctgctt ctcctgcgcc       60

tccttttcgc ccagcactag cgccttaggc cagctcgggg gatgtgagag ccgaagccct      120

tagactgcca ggcacagagt cgggtcggga tttgtcagcc aagcctcggc tccagctccg      180

caatctcggg actcacccga gcgacccagg cccgacggca agttcgggcg ggacggcggc      240

cgccgcgcgc tcaggctcag cttcgctgcc cgcccaggta gtgcccgctg gagctcgcgc      300

gctcatccgg caccactcca gggctccagg ctcctcgggc ttccggagtc gagacgtggt      360

ggagttggct cgggctgaac ttctttcggg gggctgcctg tcctggaatc gtgcgacctt      420

tcctttgcca tcctgcggtt cagcaagccc cgagtgcagt tattccctcc acccctcgcc      480

ctatcttctc ctcctccagg caacttcttt gcttcaagaa agttgcataa ttctcgagaa      540

gatgaatccg gcctcggcgc cccctccgct cccgccgcct gggcagcaag tgatccacgt      600

cacg                                                                   604


<210> 3701
<211> 2147
<212> DNA
<213> Homo sapiens

<400> 3701
attgttcgca gctgatgtca ctcgcagttg tgagcggccg cctctcccgg ggacaatgtg       60

ggactgagcg gcccagccgc cgtgccgccg ccgccgccgc cgcaggacag ccccagcgag      120

gccatttcca gcacatagaa gagagattgg aaaccaacgt gcagaactgc cagtcccctg      180

acacgctgtg ccccacccac tgcagcccag tgctgaatga accctgccca gaggtgtctg      240

tagtgagctt ctgccctagt gacttttgag ccggccaggt tgcagcgcgg acacactcgc      300

aggtcgctgt ggccccagcc tcgcctgaca gaatgagcgg ctcggacggg ggactggagg      360

aggagccaga gctcagcatc accctcacgc tgcggatgct gatgcacggg aaggaagtgg      420

gcagcatcat cgggaagaag ggcgagactg taaagcgaat ccgggagcag agcagtgccc      480

ggatcaccat ctccgagggc tcctgccctg aacgcatcac caccatcacc gggtctacag      540

cagctgtctt ccatgcagtc tccatgattg ctttcaaact ggatgaggac ctttgtgctg      600

ctcctgcaaa tggtggaaat gtctccaggc ctccagtgac cctgcgcctt gtcatccctg      660

ccagtcagtg tggctcactg attgggaagg ctggcaccaa gatcaaggag atccgagaga      720

ctacgggtgc ccaggtacag gtggcagggg acctgctccc caactccaca gagcgagctg      780

ttacggtatc tggggtgcct gatgccatca tcctgtgtgt gcgccagatc tgcgctgtta      840

tcctggagtc cccacccaaa ggagccacta tcccctacca tccgagcctc tccctaggta      900

ctgttcttct ctctgccaac cagggcttct ctgtccaggg tcagtatggg gctgtgaccc      960

cagctgaggt caccaagctc cagcagctct caagccatgc ggtccccttt gccacaccca     1020

gcgtggtgcc aggactggat cccggcacac agaccagctc acaggagttc ttggttccca     1080

acgatttgat tggctgtgtg atcgggcgcc agggcagcaa gatcagcgag atccggcaga     1140

tgtcaggggc acatatcaag atcgggaacc aagcagaggg cgctggggag cggcatgtca     1200

ccatcactgg ctctccggtc tccatcgccc tggcccagta cctcatcact gcctgtctag     1260

agacggccaa gtctacctct ggggggacgc ccagctcggc ccccgcagac ctgcctgccc     1320

ccttctcgcc acccctgacg gccctgccca cagctccccc tggcctgctg ggcacaccct     1380

atgccatctc cctctccaac ttcatcggcc tcaagcccat gcccttcttg gctttaccac     1440

ctgcttcccc agggccgccg ccgggcttgg cggcctacac tgccaagatg gcagcagcta     1500

atgggagcaa gaaggctgag cggcagaaat tctcccccta ctgaggccag ctgaggtaca     1560

ggcaggggca ggcaggacca ccagcagggg gctgcctctg caccctaccc gcccaaggag     1620

actccaccct ggggtcccaa acgccgctaa cgcccagacg catggatgca ccccctaccc     1680

tgcctccatc tatgggagtt ctttctctca gagtgggggc agtttctggc ccaggggtct     1740

gagctgcggc agccccaggg cagggggccc tacctcctca gctctgtgct tggatacagg     1800

gagcagccag gagactccct agtgccccca ccatggcggg tgtcactcac gcactcccca     1860

tcccttaggg cttcctggcc tactgcatcc ttgtgggagt cagggaggag ggcccgttgg     1920

gtagctgggg ccaggcttct ctccccacca cctgcagatt tcttgctgct tccactgata     1980

cccttttgac tggaatgaac tggctgggct tgtcaggggg caccccaaag agggggcact     2040

gccaggtagc tgggggagtg gcatggggca ggggcccagt tctcagcagc agacactctg     2100

tacagttttt tcaatccctg tttttgaata aatattctca gcgacca                   2147


<210> 3702
<211> 6981
<212> DNA
<213> Homo sapiens

<400> 3702
gggcggccta tagatccaag agaaggtcct ggacggcctc cactagatgg tagggatcat       60

tttggaagac ctcctgtaga tataagagag aatcttgtga ggccaggtat agatcatctt      120

ggtcgaagag accactttgg ctttaatcca gagaagccct gggggcatag aggagatttt      180

gatgagagag agcatcgggt tctaccggtc tatggtggtc caaaaggctt acatgaagaa      240

agaggtagat ttcggtctgg aaactatcga tttgatccta gaagtggtcc ttggaaccga      300

ggatttggac aagaagttca cagagatttt gatgaccgca gaagaccctg ggagaggcaa      360

agggataggg atgacagaga ttttgatttc tgcagagaaa tgaatggaaa tcgtcttgga      420

cgagacagaa ttcaaaacac ttgggttccc cctcctcatg ctcgggtttt tgattatttt      480

gaaggggcca cttctcaacg aaaaggtgat aatgtgcctc aggttaatgg tgaaaataca      540

gagagacatg ctcagccacc acctatacca gtacagaatg atcctgaact ttatgaaaaa      600

ctgacatctt caaatgaaat aaacaaggag aagagtgaca cagttgctga tatagaaagt      660

gaaccagtgg tagaaagcac agaaactgag gggacataat catcactcag taggttaatg      720

atgaaatggc aggtaattca cacttttgga cagagcgcac cgcccccgtg gaatcaccct      780

acagaagagg ccagctataa aggatgtctc acacctttaa gatcagtgtt tctcaatgtg      840

tggaccatgg atacctgtat tagaataccc aaaggatttg tttaaaattc aggctgagcc      900

cttcccaaga cctaatagag ctaaaagctt tgggagtagg tggaggaaac ctgcatcttt      960

acccagcaat ccaggacaga atgacttgga agataacgga gcttcgaagc ttctagcaga     1020

atatgaagtc tttcgtcttc agctacctgg gttaagttta agcagggctc tgtgtatgaa     1080

tgacaaggat accttcagcc agctcattct ggatgaatga atgattacac taagtgtcct     1140

ccacattcct ctgtgggctc acttcatgga ctcactttgc gtgcttgtta aatgtgctgt     1200

gttgctccca agaccatgta aagcctactg accactaacc tccctcacag cagaaactag     1260

acgtcaggtt aaaatgggca actccgacag tcagtacacc cttcaaggat ctaaaaatca     1320

tagcaatact attactggtg ctaagcaaat tccttgctcc ctgaaaatac gtggcattca     1380

tgcaaaagag gaaaagtcat tgcatggatg gggtcacgga agcaacggag caggttacaa     1440

gtccaggtcc ctggcccgaa gctgcctttc tcactttaag agtaaccagc cttacgcatc     1500

gagactcggt ggccccacat gcaaggtctc cagaggtgtt gcctactcca cgcacaggac     1560

aaatgcccca gggaaggatt tccagggcat cagtgctgct ttctcaactg agaatggctt     1620

ccactctgtt ggccacgagc tggcagataa ccacatcacc tccagagact gcaacggaca     1680

ccttctcaac tgctacggga ggaatgagag cattgcctcc accccaccgg gcgaagaccg     1740

caagagcccc cgagtgctca tcaaaacgct ggggaagctg gatgggtgtt taagggtcga     1800

gttccacaat ggtggcaacc ccagcaaagt gcctgcagag gactgcagtg agccggtgca     1860

gctgctgagg tactcaccta ccttagcatc ggaaacctcc cctgtgcctg aagccaggag     1920

ggggtccagc gccgattccc tgcccagcca tcgcccctct cccacggact ctcgcctgcg     1980

gtccagcaaa ggcagctccc tgagttctga gtcatcctgg tacgactccc cttggggcaa     2040

tgctggagag ctgagcgagg ctgagggctc cttcctggcc cccggcatgc ctgaccccag     2100

tctccatgcc agcttcccac ctggcgatgc caaaaagcct ttcaaccaaa gctcttccct     2160

ctcctccctc cgggaactgt acaaagatgc caacctgggg agcctctccc cctcaggtat     2220

ccgcctttct gatgaataca tgggcacgca tgccagcctg agcaaccgtg tctcttttgc     2280

ttccgacatt gatgtgccct ccagagtggc acacggggac cccatccagt acagttcctt     2340

cactctcccc tgtcggaagc ccaaagcctt tgttgaggat actgcgaaga aggactccct     2400

caaagccagg atgcgacgga tcagtgactg gacgggaagc ctctcaagga agaaaaggaa     2460

actccaggag ccgaggtcca aggagggcag tgactacttt gacagtcgct ctgatggact     2520

gaatacagat gtgcagggat cctcccaggc atctgctttt ctgtggtcag ggggctctac     2580

tcagatcctg tctcagagaa gtgaatccac acatgcgatt ggcagcgatc ccctccggca     2640

gaacatttat gagaatttca tgcgagagtt ggaaatgagc aggaccaaca ctgagaacat     2700

agaaacatct acagaaaccg ccgagtccag cagcgagtca ctcagctctc tggaacagct     2760

ggatctgctc tttgagaagg aacagggggt ggtccggaag gccgggtggc tcttcttcaa     2820

gcccctggtc actgtgcaga aggaaaggaa gcttgagctg gtggcacgaa ggaaatggaa     2880

acagtactgg gtaacgctga aaggatgcac gctgctgttt tatgagacct atgggaagaa     2940

ttccatggat cagagcagtg cccctcggtg tgctctgttt gcagaagaca gcatagtgca     3000

gtctgttcca gagcatccca agaaagaaaa tgtgttctgc ctcagcaact cctttggaga     3060

tgtctacctt ttccaggcca ccagccagac agatctagaa aactgggtca ctgctgtaca     3120

ctctgcttgt gcatcccttt ttgcaaagaa gcatgggaaa gaggacacgc tgcggctgct     3180

gaagaaccag accaaaaacc tgcttcagaa gatagacatg gacagcaaga tgaagaagat     3240

ggcagagctg cagctgtccg tggtgagcga cccaaagaac aggaaagcca tagagaacca     3300

gatccagcaa tgggagcaga atcttgagaa atttcacatg gatctgttca ggatgcgctg     3360

ctatctggcc agcctacaag gtggggagtt accgaaccca aagagtctcc ttgcagccgc     3420

cagccgcccc tccaagctgg ccctcggcag gctgggcatc ttgtctgttt cctctttcca     3480

tgctctggta tgttctagag atgactctgc tctccggaaa aggacactgt cactgaccca     3540

gcgagggaga aacaagaagg gaatattttc ttcgttaaaa gggctggaca cactggccag     3600

aaaaggcaag gagaagagac cttctataac tcaggtcgat gaacttctgc atatatatgg     3660

ttcaacagta gacggtgttc cccgagacaa tgcatgggaa atccagactt atgtccactt     3720

tcaggacaat cacggagtta ctgtagggat caagccagag cacagagtag aagatatttt     3780

gactttggca tgcaagatga ggcagttgga acccagccat tatggcctac agcttcgaaa     3840

attagtagat gacaatgttg agtattgcat ccctgcacca tatgaatata tgcaacaaca     3900

ggtttatgat gaaatagaag tctttccact aaatgtttat gacgtgcagc tcacgaagac     3960

tgggagtgtg tgtgactttg ggtttgcagt tacagcgcag gtggatgagc gtcagcatct     4020

cagccggata tttataagcg acgttcttcc cgatggcctg gcgtatgggg aagggctgag     4080

aaagggcaat gagatcatga ccttaaatgg ggaagctgtg tctgatcttg accttaagca     4140

gatggaggcc ctgttttctg agaagagcgt cggactcact ctgattgccc ggcctccgga     4200

cacaaaagca accctgtgta catcctggtc agacagtgac ctgttctcca gggaccagaa     4260

gagtctgctg ccccctccta accagtccca actgctggag gaattcctgg ataactttaa     4320

aaagaataca gccaatgatt tcagcaacgt ccctgatatc acaacaggtc tgaaaaggag     4380

tcagacagat ggcactctgg atcaggtttc ccacagggag aaaatggagc agacattcag     4440

gagtgctgag cagatcactg cactgtgcag gagttttaac gacagtcagg ccaacggcat     4500

ggaaggaccg cgggagaatc aggatcctcc tccgaggtct ctggcccgcc acctgtctga     4560

tgcagaccgc ctccgcaaag tcatccagga gcttgtggac acagagaagt cctacgtgaa     4620

ggatttgagc tgcctctttg aattatactt ggagccactt cagaatgaga cctttcttac     4680

ccaagatgag atggagtcac tttttggaag tttgccagag atgcttgagt ttcagaaggt     4740

gtttctggag accctggagg atgggatttc agcatcatct gactttaaca ccctagaaac     4800

cccctcacag tttagaaaat tactgttttc ccttggaggc tctttccttt attacgcgga     4860

ccactttaaa ctgtacagtg gattctgtgc taaccatatc aaagtacaga aggttctgga     4920

gcgagctaaa actgacaaag ccttcaaggc ttttctggac gcccggaacc ccaccaagca     4980

gcattcctcc acgctggagt cctacctcat caagccggtt cagagagtgc tcaagtaccc     5040

gctgctgctc aaggagctgg tgtccctgac ggaccaggag agcgaggagc actaccacct     5100

gacggaagca ctaaaggcaa tggagaaagt agcgagccac atcaatgaga tgcagaagat     5160

ctatgaggat tatgggaccg tgtttgacca gctagtagct gagcagagcg gaacagagaa     5220

ggaggtaaca gaactttcga tgggagagct tctgatgcac tctacggttt cctggttgaa     5280

tccatttctg tctctaggaa aagctagaaa ggaccttgag ctcacagtat ttgtttttaa     5340

gagagccgtc atactggttt ataaagaaaa ctgcaaactg aaaaagaaat tgccctcgaa     5400

ttcccggcct gcacacaact ctactgactt ggacccattt aaattccgct ggttgatccc     5460

catctccgcg cttcaagtca gactggggaa tccagcaggg acagaaaata attccatatg     5520

ggaactgatc catacgaagt cagaaataga aggacggcca gaaaccatct ttcagttgtg     5580

ttgcagtgac agtgaaagca aaaccaacat tgttaaggtg attcgttcta ttctgaggga     5640

gaacttcagg cgtcacataa agtgtgaatt accactggag aaaacgtgta aggatcgcct     5700

ggtacctctt aagaaccgag ttcctgtttc ggccaaatta gcttcatcca ggtctttaaa     5760

agtcctgaag aattcctcca gcaacgagtg gaccggtgag actggcaagg gaaccttgct     5820

ggactctgac gagggcagct tgagcagcgg cacccagagc agcggctgcc ccacggctga     5880

gggcaggcag gactccaaga gcacttctcc cgggaaatac ccacaccccg gcttggcaga     5940

ttttgccgac aatctcatca aagagagtga catcctgagc gatgaagatg atgaccaccg     6000

tcagactgtg aagcagggca gccctactaa agacatcgaa attcagttcc agagactgag     6060

gatttccgag gacccagacg ttcaccccga ggctgagcag cagcctggcc cggagtcggg     6120

tgagggtcag aaaggaggag agcagcccaa actggtccgg gggcacttct gccccattaa     6180

acgaaaagcc aacagcacca agagggacag aggaactttg ctcaaggcgc agatccgtca     6240

ccagtccctt gacagtcagt ctgaaaatgc caccatcgac ctaaattctg ttctagagcg     6300

agaattcagt gtccagagtt taacatctgt tgtcagtgag gagtgttttt atgaaacaga     6360

gagccacgga aaatcatagt atgattcaat ccagatatgg gttaaattcc tcattttact     6420

tttaaactgg tggtaaagtg gaaattgcaa aaaaaaaaaa aaaaaaaaac tgttcattcc     6480

tgggttttgt gcagtataca ttttcccaca aaatggttgt aaagatttaa gttattttaa     6540

tttattgtgg atcagaaacc tagatgaaac tggtcagaat ctgtaaatta cttagtttat     6600

atccactttg agcaggtatc aaatgattta ggatccttaa aattacattc taataattaa     6660

gttatgtgga aaaagtaagg ctggggaagt cgtgattaat agttttcaaa gggccatttt     6720

ttaaaatcct ctgggcattt tctttcagct gtttgttagt ttttgcttta tttaaagcat     6780

atttaagtta ttttaatgtg gtttaggggc aaaatgtgca gatacttcat ttttgtaaga     6840

tagattgtaa tagatgctgt ttatactaaa catgtcataa ctatctatac agtatatatt     6900

aaaagaaagc ttgtactgta tcttatttga tgatatttat tttctctgcc aagctgtata     6960

gtaaaaggaa aataagtcac a                                               6981


<210> 3703
<211> 727
<212> DNA
<213> Homo sapiens

<400> 3703
cgactctgga ggaagactgg agcctttgcg gcggcgctgc ccctcccctg gtccccgcga       60

gctcggaggg cccggctggt gctgcggggg ccccgggagg ttgaaaacta agcatgggga      120

agagctgcaa ggtggtcgtg tgtggccagg cgtctgtggg caaaacttca atcctggagc      180

agcttctgta tgggaaccat gtagtgggtt cggagatgat cgagacgcag gaggacatct      240

acgtgggctc cattgagaca gaccgggggg tgcgagagca ggtcaccatc gtggtccttg      300

gcaacaagtg tgacttacag gagcagcggc gtgtagaccc agatgtggct cagcactggg      360

ccaagtcaga gaaggtgaag ctgtgggagg tgtcagtggc ggaccggcgc tccctcctgg      420

agccctttgt ctacttggcc agcaagatga cgcaacccca gagcaagtct gccttccccc      480

tcagccggaa gaacaagggc agcggctcct tggatggctg aagagctgcc gttcctcttt      540

cacgatccca gccccatttc agtgtctggg gctctggtag atgtgttgag ggcaaagtag      600

aggacaagct gtctttccca gtcagccagg gagctccccg ccaggccacg ccccagccac      660

tttgctccct ctcacctctg ggaagtgcaa atactcttgg ttgacatccc cttcctcagc      720

cctccca                                                                727


<210> 3704
<211> 5033
<212> DNA
<213> Homo sapiens

<400> 3704
cggagccgaa acaccggtag gagcggggag gtgggtacta cacaaccgtc tccagccttg       60

gtctgagtgg actgtcctgc aggtaaagta cttctcttcc tggtcaggtt gtcacgctct      120

tacttcctgc cttgtccgcg agcgcctgga aaatagaggc cttgagcccg agcggcgaag      180

tccgggcttg aagctgccgc tgggagattt ctcttgctgt cacccctccc ccctcggccg      240

ctccccggcg gcccgggctc ccgcgcgcag ctcccgggcg ccacttttcc aagctactca      300

aatgtctcgg ggaggccctg agcctcgcag atcttttctt taaaaaatcc tagtctctat      360

ctggaaaagg gcgtctcccc ctacccctct tccttctgcc aacggactag tcaccgggtc      420

tcagccttcg ctggtgacct ttcatggttt actgtccaac gggactccgc ctggggagct      480

ggagagacaa actcttgcca ctccaaaatt agcaagcgct gccagcgtcc gacttgaagt      540

tgctagtggt tagtcccagc cttcgccctt cgcggtccga ccgctgagag gagggagact      600

tcgttatgcc ccgggccgtc aacggcgcca ggagctaaag ggcgggcaga cgaaagcggg      660

cggcgagtcg ccagttagtc ttcaccgctc tggagagagt tgctagccac gggatcctga      720

cccggacacg aactcgtttc tccacgtcgg tgcgcgcttg catccctggc cccgaaagcg      780

tgggaatgtc cggaaatgct ggcgtatggg agttccttaa ttagaaatgc gttagcgaat      840

attatacgct tatactatgg gcggacgggt ggagagcctt aaaaacaaca acaacaaact      900

aagcagttgc tcaatcgttg attgatcctc aggcacgtct agattttccc acttacatag      960

gtcttgttaa gaaaccagtc ctgccttctt gccactcgtg tctttcgatg gctcccttcc     1020

cgaagtcccg ctgcctctaa gcggagtgtt aagcggggct ctcggaagcc ggtggaccga     1080

gatttccccg ggtggggcgg gcgcggtgta gcggcccgcg ggctgacttg ctcccggctg     1140

tcccccggcc ccagcgacca tgccccgtaa aggcacccag ccctccactg cccggcgcag     1200

agaggaaggg ccgccgccgc cgtcccctga cggcgccagc agcgacgcgg agcctgagcc     1260

gccgtccggc cgcacggaga gcccagccac cgccgcagag actgcaagtg aggaacttga     1320

taatagaagt ttagaagaga ttttgaacag cattcctcct cccccgcctc cagcaatgac     1380

caatgaagct ggagctcctc ggcttatgat aactcatatt gtaaaccaga acttcaaatc     1440

ctatgctggg gagaaaattc tgggaccttt ccataagcgc ttttcctgta ttatcgggcc     1500

aaatggcagt ggcaaatcca atgttattga ttctatgctt tttgtgtttg gctatcgagc     1560

acaaaaaata agatctaaaa aactctcagt attaatacat aattctgatg aacacaagga     1620

cattcagagt tgtacagtag aagttcattt tcaaaagata attgataagg aaggggatga     1680

ttatgaagtc attcctaaca gtaatttcta tgtatccaga acggcctgca gagataatac     1740

ttctgtctat cacataagtg gaaagaaaaa gacatttaag gatgttggaa atcttcttcg     1800

aagccatgga attgacttgg accataatag atttttaatt ttacagggtg aagttgaaca     1860

aattgctatg atgaaaccaa aaggccagac tgaacacgat gagggtatgc ttgaatattt     1920

agaagatata attggttgtg gacggctaaa tgaacctatt aaagtcttgt gtcggagagt     1980

tgaaatatta aatgaacaca gaggagagaa gttaaacagg gtaaagatgg tggaaaagga     2040

aaaggatgcc ttagaaggag agaaaaacat agctatcgaa tttcttacct tggaaaatga     2100

aatatttaga aaaaagaatc atgtttgtca atattatatt tatgagttgc agaaacgaat     2160

tgctgaaatg gaaactcaaa aggaaaaaat tcatgaagat accaaagaaa ttaatgagaa     2220

gagcaatata ctatcaaatg aaatgaaagc taagaataaa gatgtaaaag atacagaaaa     2280

gaaactgaat aaaattacaa aatttattga ggagaataaa gaaaaattta cacagctaga     2340

tttggaagat gttcaagtta gagaaaagtt aaaacatgcc acgagtaaag ccaaaaaact     2400

ggagaaacaa cttcaaaaag ataaagaaaa ggttgaagaa tttaaaagta tacctgccaa     2460

gagtaacaat atcattaatg aaacaacaac cagaaacaat gccctcgaga aggaaaaaga     2520

gaaagaagaa aaaaaattaa aggaagttat ggatagcctt aaacaggaaa cacaagggct     2580

tcagaaagaa aaagaaagtc gagagaaaga acttatgggt ttcagcaaat cggtaaatga     2640

agcacgttca aagatggatg tagcccagtc agaacttgat atctatctca gtcgtcataa     2700

tactgcagtg tctcaattaa ctaaggctaa ggaagctcta attgcagctt ctgagactct     2760

caaagaaagg aaagctgcaa tcagagatat agaaggaaaa ctccctcaaa ctgaacaaga     2820

attaaaggag aaagaaaaag aacttcaaaa acttacacaa gaagaaacaa actttaaaag     2880

tttggttcat gatctctttc aaaaagttga agaagcaaag agctcattag caatgaatcg     2940

aagtaggggg aaagtccttg atgcaataat tcaagaaaaa aaatctggca ggattccagg     3000

aatatatgga agattggggg acttaggagc cattgatgaa aaatacgacg tggctatatc     3060

atcctgttgt catgcactgg actacattgt tgttgattct attgatatag cccaagaatg     3120

tgtaaacttc cttaaaagac aaaatattgg agttgcaacc tttataggtt tagataagat     3180

ggctgtatgg gcgaaaaaga tgaccgaaat tcaaactcct gaaaatactc ctcgtttatt     3240

tgatttagta aaagtaaaag atgagaaaat tcgccaagct ttttattttg ctttacgaga     3300

taccttagta gctgacaact tggatcaagc cacaagagta gcatatcaaa aagatagaag     3360

atggagagtg gtaactttac agggacaaat catagaacag tcaggtacaa tgactggtgg     3420

tggaagcaaa gtaatgaaag gaagaatggg ttcctcactt gttattgaaa tctctgaaga     3480

agaggtaaac aaaatggaat cacagttgca aaacgactct aaaaaagcaa tgcaaatcca     3540

agaacagaaa gtacaacttg aagaaagagt agttaagtta cggcatagtg aacgagaaat     3600

gaggaacaca ctagaaaaat ttactgcaag catccagcgt ttaatagagc aagaagaata     3660

tttgaatgtc caagttaagg aacttgaagc taatgtactt gctacagccc ctgacaaaaa     3720

aaagcagaaa ttgctagaag aaaacgttag tgctttcaaa acagaatatg atgctgtggc     3780

tgagaaagct ggtaaagtag aagctgaggt taaacgctta cacaatacca tcgtagaaat     3840

caataatcat aaactcaagg cccaacaaga caaacttgat aaaataaata agcaattaga     3900

tgaatgtgct tctgctatta ctaaagccca agtagcaatc aagactgctg acagaaacct     3960

tcaaaaggca caagactctg tcttgcgtac agagaaagaa ataaaagata ctgagaaaga     4020

ggtggatgac ctaacagcag agctgaaaag tcttgaggac aaagcagcag aggtcgtaaa     4080

gaatacaaat gctgcagaga tttcaaaaat atcactgcat cctatagaag ataatcctat     4140

tgaagagatt tcggttctaa gcccagagga tcttgaagcg atcaagaatc cagattctat     4200

aacaaatcaa attgcacttt tggaagcccg gtgtcatgaa atgaaaccaa acctcggtgc     4260

catcgcagag tataaaaaga aggaagaatt gtatttgcaa cgggtagcag aattggacaa     4320

aattacttat gaaagagaca gttttagaca ggcatatgaa gatcttcgga aacaaaggct     4380

taatgaattt atggcaggtt tttatataat aacaaataaa ttaaaggaaa attaccaaat     4440

gcttactttg ggaggggacg ccgaactcga gcttgtagac agcttggatc ctttctctga     4500

aggaatcatg ttcagtgttc gaccacctaa gaaaagttgg aaaaagatct tcaacctttc     4560

gggaggagag aaaacactta gttcattggc tttagtattt gctcttcacc actacaagcc     4620

cactcccctt tacttcatgg atgagattga tgcagccctt gattttaaaa atgtgtccat     4680

tgttgcattt tatatatatg aacaaacaaa aaatgcacag ttcataataa tttctcttcg     4740

aaataatatg tttgagattt cggatagact tattggaatt tacaagacat acaacataac     4800

aaaaagtgtt gctgtaaatc caaaagaaat tgcatctaag ggactttgtt gaactttatg     4860

ctgaagattc ttcaagttga ttcagtgtat tactgatttt tttctatttg taaaggatta     4920

tgagttgtat aaaatacata ctccctaaac tagatcatga aactggtttc tgttttatgc     4980

agttgtcatt tgtaaagtct aataaaatat tctctataat tgcttctaga tta            5033


<210> 3705
<211> 493
<212> DNA
<213> Homo sapiens

<400> 3705
acaactggag cagccgggaa cagctctgac cacagtggtt ccggggagaa gcctttccag       60

gacccatgtg taggcacaac tgttttccct gatcaggata cttgcggcac tcaagaattc      120

tccgaagttt gaaggttatg aatggttatc actcaaggat tcagaactaa gcagaggaaa      180

gaaattccta agggaacact gctcagaaag tactgcagca tgtcttcaaa tgcctgagga      240

tcaagttgga aaactagaag caacagaaaa cacaataagc gcaatggcgg cggccgcggc      300

ggagcagcaa cagttctacc tgctcctggg aaacctgctc agccccgaca atgtggtccg      360

gaaacaggca gaggaaacct atgagaatat cccaggccag tcaaagatca cattcctctt      420

acaagccatc agaaatacaa cagctgctga agaggctaga caaatggccg ccgttctcct      480

aagacgtctc ttg                                                         493


<210> 3706
<211> 4246
<212> DNA
<213> Homo sapiens

<400> 3706
gatgagattg atgattcttt ctcctggaaa acctttcatc acagagattc atctcagcat       60

taaagggcag tatttaaagt cagttggcaa gcagtggaat aagatttttg taaagaaacc      120

ttgtgcagca tggattctct accagatgaa ttttttgtga ggcatcctgc tgtggaggat      180

cagaggaagg aagaaactga gaataagcta gaaaaatcat ctggtcaact gaacaaacag      240

gaaaatgaca tacctactga tcttgtccct gttaacctac tattagaagt gaagaagtta      300

ttaaatgcaa ttaatactct accaaaaggt gtggttcctc acattaagaa gttcttacaa      360

gaagattttt ccttccaaac tatgcagaga gaagttgcag ctaacagcca gaatggtgag      420

gaaattgttc ctgctttgac tttacgtttc ttgattacac agctagaagc agcacttagg      480

aacattcaag ctggcaatta taccgcacac cagattaata ttggttatta tttgacatta      540

ctgtttttat atggagtagc actcactgaa agaggaaaga aagaggatta tacagaagct      600

gagaataaat ttctggtgat gaagatgatg atccaagaaa atgaaatttg tgaaaacttt      660

atgtctttag tttattttgg acgtggttta ctgcgatgtg ctcaaaagag atataatgga      720

ggactgctag aatttcataa aagcttacaa gaaattggag acaaaaatga ccattggttt      780

gacatagatc ctacagaaga tgaagattta cctacaactt ttaaagatct tcttaataat      840

tttatcaaga caactgaaag caatataatg aagcagacga tttgtagtta cctagattgt      900

gaacgatctt gtgaagctga cattttgaag aacaccagtt ataagggatt ttttcagtta      960

atgtgcagta aaagttgctg tgtttatttc cataaaattt gctggaaaaa gttcaagaat     1020

ttaaagtatc caggtgaaaa tgatcagagt tttagtggga aaaaatgttt gaaggaagga     1080

tgtacaggtg acatggtaag gatgctgcaa tgtgatgtac ctggaattgt taaaattttg     1140

tttgaagttg tgagaaagga tgaatatatc accattgaaa atttaggagc aagttataga     1200

aagttgatat ctctgaaaat aactgatact gatataagac cgaagatcag tttaaaattt     1260

aatacaaaag atgaaatgcc tatcttcaag cttgattata attatttcta tcatctgctt     1320

catataatta ttatttctgg tactgacatt gttcgacaaa tatttgatga ggctatgcca     1380

cctcctcttt tgaaaaaaga gcttcttata cacaagaatg tgctggaatc ctactacaac     1440

catctttgga ccaatcatcc tttgggtgga tcatggcatc tgctttatcc tcctaacaag     1500

gagttaccgc aatccaaaca gtttgactta tgcctcctgt tagctcttat aaaacattta     1560

aatgtgttcc ctgcacccaa aaaaggatgg aatatggaac cgccatcttc tgacatctct     1620

aaatctgcag acatcctgag actgtgcaaa tacagggata tcctccttag tgagattttg     1680

atgaatggtc tcactgagtc acagttcaat tcaatttgga aaaaagtttc agatattctt     1740

ctgcgccttg ggatgatgca agaggatatt gacaaagtga aggagaatcc cattgagaat     1800

atctcccttg attaccatca gctatctgtc tacctaggca taccagtacc agaaatcata     1860

cagaggatgt tatcctgcta tcaacaagga attgctctac agtcaataac aggcagtcag     1920

cgtattgaaa tagaagagtt acagaatgag gaagaagaac taagtccacc tctcatggag     1980

tacaatataa atgtgaaatc acaccctgag atacagtttg cagaaattaa taaagatggg     2040

acctcaatac ccagtgaatc ttcaacagaa tctcttaaag atctccagga agttaagagt     2100

aaacaaagga aaaagaagaa gactaagaat aaaaagaata aagactcaaa agaagaccaa     2160

gtcccatatg tggtagaaaa ggaagagcag ttgaggaaag aacaagcaaa tccacactca     2220

gtcagtagac ttataaaaga tgatgcaagt gatgttcaag aggattctgc aatggaagac     2280

aagttctata gcctggatga attgcatatt ctggacatga tagagcaggg ctcagctggc     2340

aaagtaacta cagactatgg agaaactgaa aaggaaaggc ttgctcgtca aaggcagctt     2400

tataaattgc actatcagtg tgaagatttc aaaagacagt tgagaacagt gacttttcgg     2460

tggcaagaaa accaaatgca gattaaaaag aaagacaaaa ttatcgcatc tcttaatcaa     2520

caagttgctt ttggaatcaa taaggtttcc aaattacagc gtcaaatcca tgctaaagat     2580

aatgaaatca agaaccttaa agagcaactt tctatgaaaa gatctcagtg ggaaatggaa     2640

aaacataatc tggaaagcac aatgaaaaca tacgtaagca aactgaacgc agaaactagc     2700

agagctttaa cagccgaggt gtatttctta cagtgtcgta gggattttgg tttgcttcat     2760

ctagagcaga ctgaaaagga atgtctcaat cagcttgcca gggtgactca catggcagca     2820

agcaacctag aatcacttca attaaaggct gcggtagaca gttggaatgc cattgtggca     2880

gatgttagaa acaagattgc attcctcagg acacagtaca atgaacaaat aaacaaagtc     2940

aagcaaggat ttgccttgag taccttgcct ccagtccagc ttcctcctcc accacccagt     3000

cctgagatac tgatgcagca gttcttagga agacctcttg tgaaagaatc tttctttaga     3060

cccatactta ctgttcctca aatgcctgca gtttgcccgg gagtcgtctc tgcaactggc     3120

caacctagag cccccctgat gactggcata gcctgggctc tgccagcgcc tgtgggagac     3180

gctgtgcctc ccagtgcagg tctgcggagt gatccctcca tcatgaattg ggagagaatt     3240

acagacaggc tgaaaactgc ctttccacag caaaccagaa aggaacttac agatttctta     3300

cggaaattga aggatgctta tggaaaatcc ttgtctgaac tgacatttga tgaaattgtt     3360

tgcaagattt cccagtttat tgaccccaaa aagtctcaga gtcaaggaaa atcagtgtca     3420

aatgttaatt gtgtttcacc tagtcattct ccatcacagc ctgatgctgc ccagccccca     3480

aaaccagcct ggaggccact cacttcacag ggtcctgcca catgggaagg agccagtaat     3540

ccagatgagg aagaggaaga agaagagcct tgtgtgatct gtcatgagaa tctgtctcca     3600

gaaaatcttt cagttttgcc ttgcgctcac aaattccatg ctcagtgcat tagaccatgg     3660

ttgatgcaac aggggacatg tccaacgtgc agactccacg ttttgctacc agaagaattc     3720

cctggtcacc ccagccggca gttgcccaag atctgataca aggtcggggt gtctatgcaa     3780

aggaagctca gttttctttt attatgagct gcttgtttga gtggtgtaaa actatgtgct     3840

cttcaatata gtgctaaaga agccagctaa ttttatcaaa gcagcagcca aagaagtcag     3900

gacaaatctt caggacttgt gaaatgaact gaaagagctt gaagcagatg gaattttaat     3960

agttacacta tatatgctct tagtaggttt ttttcttgta gtggaaacat aactgttagc     4020

atatttctta ggatgttttt tcttgtcttt ttaaattctt atttcactca tcctttactc     4080

tcccctcaag tattctacac tttaatttcc tgaaataaat ttaaggaaaa gggaaatagt     4140

aaagaagtag gaatgggtgc agcacaccag catggcacat gaatacacat gtaactaacc     4200

tgcacattgt gcacatgtac cctaaaactt aaagtataat aataat                    4246


<210> 3707
<211> 2730
<212> DNA
<213> Homo sapiens

<400> 3707
cttttaggag agcactgctg cagccggcag tggagagcct gggcagggag acagggagaa       60

aactccggca gcagggtggt ctctagggct gacctcggag cctggggaca ggggagccta      120

tgccgcactg aaggcgggac gctactcgtt tgtgaacagc caggagtgga cgctgagccg      180

ctccgtaccg gagcttaaag tgggcatagt ggggaacctg tctagcggga agtcagccct      240

ggtgcaccgc tatctgacgg ggacctatgt ccaggaggag tcccctgaag gggggcggtt      300

taagaaggag attgtggtgg atggccagag ttacctgctg ctgatccgag atgaaggagg      360

cccccctgag ctccagtttg ctgcctgggt ggatgcagtg gtgtttgtgt tcagcctgga      420

ggatgaaatc agtttccaga cggtgtacaa ctacttcctg cgtctctgca gcttccgcaa      480

cgccagcgag gtgcccatgg tgcttgtggg cacgcaggat gccatcagcg ctgcgaatcc      540

ccgggttatc gacgacagca gagcccgcaa gctctccaca gatctgaagc ggtgcaccta      600

ctatgagacg tgcgcgacct acgggctcaa tgtggagcgt gtcttccagg acgtggccca      660

gaaggtagtg gccttgcgaa agaagcagca actggccatc gggccctgca agtcactgcc      720

caactcgccc agccactcgg ccgtgtccgc cgcctccatc ccggccgtgc acatcaacca      780

ggccacgaat ggcggcggca gcgccttcag cgactactcg tcctcagtcc cctccacccc      840

cagcatcagc cagcgggagc tgcgcatcga gaccatcgct gcctcctcca cccccacacc      900

catccgaaag cagtccaagc ggcgctccaa catcttcacg tctcggaagg gtgctgacct      960

ggaccgggag aagaaggctg ccgagtgcaa ggtggacagc atcgggagcg gccgcgccat     1020

ccccatcaag caggggatcc tgctaaagcg gagcggcaag tccctgaaca aggagtggaa     1080

gaagaagtat gtgacgctct gtgacaacgg gctgctcacc tatcacccca gcctgcatga     1140

ttacatgcag aacatccacg gcaaggagat tgacctgctg cggacaacgg tgaaagtgcc     1200

agggaagcgc ctgccccgag ccacacctgc cacagccccg ggcaccagcc cccgtgccaa     1260

cgggctgtcc gtggagcgga gtaacacaca gctgggtggg ggcacagagg cagaggagtc     1320

gtttgaattt gtggtggtgt ccctcactgg gcagacgtgg cacttcgagg cttcaacggc     1380

ggaggagcgg gagctgtggg ttcagagtgt gcaggcccag atccttgcca gcctgcaagg     1440

ctgccgcagt gccaaggaca agactcgact ggggaaccag aacgcagctc tggctgtgca     1500

ggccgtccgc accgtccgcg gcaacagctt ttgtatcgac tgcgatgcac ccaatccaga     1560

ctgggccagc ctgaacctgg gtgccctgat gtgcattgag tgctcaggca tccaccgaca     1620

cctgggggct cacctgtccc gggtgcgctc ccttgacctc gatgactggc cgcctgagct     1680

gctggctgtc atgactgcca tgggcaatgc cctcgccaac agcgtctggg agggggcctt     1740

gggtggctac tccaagccag ggcctgatgc ctgcagagag gagaaggaac gctggatacg     1800

ggccaagtat gaacagaagc tcttcctggc cccactgcca agctcagatg tgccactggg     1860

gcagcagctg ctccgggccg tggtggaaga tgacctgcgg ctgttggtga tgctcctggc     1920

acatggctcc aaagaggagg tgaatgagac ctatggggac ggggacgggc ggacggctct     1980

acatctctcc agtgccatgg ccaacgttgt cttcacgcag ctgctcatct ggtacggggt     2040

ggacgtgagg agccgggacg cccggggcct gactccactg gcatatgctc gccgggccgg     2100

cagccaggag tgtgcagaca tcttgatcca gcatggctgc cctggggagg gctgtggctt     2160

agcgcctacc cccaacagag agcctgccaa tggcaccaac ccctctgctg agctgcaccg     2220

tagtcctagc ctcctataag gcccaggaag agggcagagg ggccagaagg actccatggc     2280

ccaaagaccc tcctccctgc aggcactgtg ggaacagaca cagagatgga gaagcaggga     2340

catgctgaga ggacgaagcc aaggaaatta gggaggagag tcaaagggat caaggagagt     2400

tggggatttg agctgcagca gagagggatg agggatttag ccctctgccc taaggtgcca     2460

ttgaaaaggg acaggaccct tcggaggtgc ctgtgaggag aggggagcag gacctctccc     2520

tcctccagat ccctgcctcc tagtgccagc ccctcacacg ccttcatcct gaaacaggaa     2580

gaggacggca ccaagttggg ggtgctggat gaaagagacg aggggtgatc tgtgagtccc     2640

atgtaaactt tgtacattgg aatatttatg tttgtgtaca tatttgatgt gtgtgtgtat     2700

gatgagccaa taaaccagac tgtgtgcgtg                                      2730


<210> 3708
<211> 1915
<212> DNA
<213> Homo sapiens

<400> 3708
atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac       60

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      120

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      180

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      240

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      300

ggccacagta gggaagaggc tggactatat cacagctgaa atatttctga ggacaatccc      360

agacccagga gatgttccag actcattttt ctgatattca gagagggcaa gagtcttggc      420

ctatgtcaca cagcagagtc caggactcca gaactccaac ctagcactct ggccagaaag      480

tcagccagag gaaggaaaac tgggaatgaa gagtcagagg tgagaagcta aagtcatgat      540

ctcaccaagg gatcaagagg tcgatattgg cggcttgtga cggtaaacac ggcaccatcc      600

tcctcctcat cccagacgga cacaggggcc tggaggagca aggaagggga agtcagacag      660

ttccacacca ccccccattg ccctcagcct tcaccccagg ccctgctcct ccctctgtac      720

ccctcacctg tggtggcagg gcatagtacc agcgagtgcg aggaagggtt gggggagctg      780

gtgaccccag gtctccccca ctggggccca gacagcccca ccccagccgc ctcagggccc      840

cggtggagtc gaaggggctg cagtggaggc gtggatggag tacaggaatt ctgatcctgg      900

agacccccaa agccccttct ccccagagct gaacccacac acgacagaga agcagggtac      960

aaagggcagg agagggaagc gagaggcagc aagccagagg cagcgactag gggtagctga     1020

aacctcagtc caggcactgc cgcatgcccc gcccctcccg gccaaggact ataccagccc     1080

agagaattag tctttttcag gacccctttc accctggtcc ctcgggtagc gcctccacta     1140

tctcagccct aagggacccc cgaaggtagc agctccaatc ccagtacagg aaggaaaagg     1200

ggaagtggga tgataggggg ttgggggcgg tagactcaga gagtcacgtg gccccagccc     1260

ctcccccgac cgatcccgaa aaaccagccc tgccagtcaa cctgccctca cctaggatct     1320

ggacctagga gtttagggcc tcggggcccc aaatccaaat tctggcccct cctgaggccc     1380

gaaatcctgc tcctggccac caccattaat ccctaatgaa aacagatgac cactctctac     1440

ccaccctagg atctttcctc caggtcccag aaccgtggct tcccggcctc tacccaggac     1500

cggggcgggg cgggggggcg gggggaaggg ggagagaggg aaggaggggt cacgaaatct     1560

gagggttccc tccccaatcc cagagtcaga ggagctggtt actgtggaaa caaacccctc     1620

cccgccaaac aaaaacaagg agggagacag ggaccaagac acgactgctc agagaggtag     1680

gcacactcag gcaggcagag gtggagggcc aaagacccgc agggacagga cagccagcca     1740

gaagttccag gcaggaacag ggcaggttcc tgcgggcagg tcctgagtca cactgacaga     1800

gaaccacgga gacgccagga ctccccgcag cagagaaacg ggccgacacc cagggaggcg     1860

cgagaataac tgaggcaagg aggaggagat gtagggaccc agagacaaga gaaaa          1915


<210> 3709
<211> 576
<212> DNA
<213> Homo sapiens

<400> 3709
tagcaggaag gttcagggcc ctgcactgtt ggggctgctc agacatttgt gcaagggagg       60

tgttttgttt tggtgtttcc atcacactca cagtgatttc tccttttccc cctttagttt      120

gaaggatgac ctctaggaag aaagtgttgc tgaaggttat catcctggga gattctggag      180

tcgggaagac atcactcatg aaccagtatg tgaataagaa attcagcaat cagtacaaag      240

ccacaatagg agctgacttt ctgaccaagg aggtgatggt ggatgacagg ctagtcacaa      300

tgcagatatg ggacacagca ggacaggaac ggttccagtc tctcggtgtg gccttctaca      360

gaggtgcaga ctgctgcgtt ctggtatttg atgtgactgc ccccaacaca ttcaaaaccc      420

tagatagctg gagagatgag tttctcatcc aggccagtcc ccgagatcct gaaaacttcc      480

catttgttgt gttgggaaac aagattgacc tcgaaaacag acaagtggcc acaaagcggg      540

cacaggcctg gtgctacagc aaaaacaaca ttccct                                576


<210> 3710
<211> 641
<212> DNA
<213> Homo sapiens

<400> 3710
gtagttgtat cttaaaggaa gagtgaataa gagggagaaa atagttacat gtactccctc       60

cttacagcct agaaaaaatg acagatctcg tagctgtttg ggatgttgct ttaagtgacg      120

gagtccacaa gatcgaattt gaacatggga ctacatcagg caaacgagta gtatatgtag      180

atggaaagga agagataaga aaagagtgga tgttcaaatt agtgggcaaa gaaacattct      240

atgttggagc tgcaaagaca aaagcgacca taaatataga cgctatcagt ggttttgctt      300

atgaatatac tctggaaatt aatgggaaaa gtctcaagaa gtatatggag gacagatcaa      360

aaaccaccaa tacttgggta ttacacatgg atggtgagaa ctttagaatt gttttggaaa      420

aagatgctat ggacgtatgg tgcaatggta aaaaattgga gacagcgggt gagtttgtag      480

atgatgggac tgaaactcac ttcagtatcg ggaaccatga ctgttacata aaggctgtca      540

gtagtgggaa gcggaaagaa gggattattc atactctcat tgtggataat agagaaatcc      600

cagagattgc aagttaatga attttcatct taagaagtaa a                          641


<210> 3711
<211> 949
<212> DNA
<213> Homo sapiens

<400> 3711
ctctgcccgc tcggttcctc agctcctctt cgtgtctttc ccccgcggtg gcgcggccct       60

gcaccccacg cgtttgcggc tgcggccggc ggccgctctg ctgggctccg ggcgctgcag      120

ctcccggcgg gcgtgtgcag cccgcagatt caggacgacc cggctgcccg gcttagcgcc      180

tttggagctc cgcgctgaag gggccttgct ccgcacaggc acggcacgca agcttttggg      240

gtgcccagtg gctctgtttt caagtcacag ccggcccgca gggtgcggac ctttccacat      300

ctcacttggg ccgctagaaa atagaagagg cttcgtgacg gagttatcag agacattgag      360

aggcaaattc ggaaaaaaga aaacattcgt cttttgggag aacagattat tttgactgag      420

caacttgaag cagaaagaga gaagatgtta ttggcaaaag gatctcaaaa atcatgactt      480

gaatgtgaaa tatctgttgg acagacaaca cgagtttgtg tgtgtgtgtt gatggagagt      540

agcttagtag tatcttcatc tttttttttg gtcactgtcc ttttaaactt gatcaaataa      600

aggacagtgg gtcatataag ttactgcttt cagggtccct tatatctgaa taaaggagtg      660

tgggcagaca ctttttggaa gagtctgtct gggtgatcct ggtagaagcc ccattagggt      720

cactgtccag tgcttagggt tgttactgag aagcactgcc gagcttgtga gaaggaaggg      780

atggatagta gcatccacct gagtagtctg atcagtcggc atgatgacga agccacgaga      840

acatcgacct cagaaggact ggaggaaggt gaagtggagg gagagacgct cctgatcgtc      900

gaatccgagg atcaggcatc agtggactta tcgcacgacc agagtgggg                  949


<210> 3712
<211> 575
<212> DNA
<213> Homo sapiens

<400> 3712
gctttcgctt catcctagag gctaaatggg ctcccctgga ctcgcctggc agaactaacc       60

acctagaaga acgttattgt aagggggaaa tgcaaacagg gtgaagacaa gaggcatagg      120

tgatggacac taaaacaaag accctgccac ccaccgggag ggaagtgaaa tctcacctca      180

acaagtgagt ccgcagagcg agaaccgtgc gacagtgcgt ctgccaatac ctggaatgta      240

ggtgttcgtt gcagtgtggc cttcccagcc ggcctctcag cacacccggc caggcagcca      300

gtgttcccag aggacacgct ggggccagac gtggaggacc ccggccacct cggggaggga      360

aagagaccaa gaaaagaacc tctgtagcct tgcttctgag agtgcaggtt tgttacaggc      420

ccaacatgtg tagcaccagt gggtgtgacc tggaagaaat ccccctagat gatgatgacc      480

taaacaccat agaattcaaa atcctcgcct actacaccag acatcatgtc ttcaagagca      540

cccctgctct cttctcacca aagctgctga gaaca                                 575


<210> 3713
<211> 5030
<212> DNA
<213> Homo sapiens

<400> 3713
gacacactcc tctacaacac cagagactcc caaacacaag gccttatatt gactcatttc       60

agctcacatc ctggcgactc tcaagagaga aacctcagag tgactaaaat ctccataatg      120

agaagacatg tacattcagt atctattttg gcattttccc caatacatct ctgctcatct      180

gactcttatc ttggcatctg cttcctggtg gatctgaact gacccataag ccacgcttac      240

tagtgatttt ccagaagatg aatccggcct cggcgccccc tccgctcccg ccgcctgggc      300

agcaagtgat ccacgtcacg caggacctag acacagacct cgaagccctc ttcaactctg      360

tcatgaatcc gaagcctagc tcgtggcgga agaagatcct gccggagtct ttctttaagg      420

agcctgattc gggctcgcac tcgcgccagt ccagcaccga ctcgtcgggc ggccacccgg      480

ggcctcgact ggctgggggt gcccagcatg tccgctcgca ctcgtcgccc gcgtccctgc      540

agctgggcac cggcgcgggt gctgcgggta gccccgcgca gcagcacgcg cacctccgcc      600

agcagtccta cgacgtgacc gacgagctgc cactgccccc gggctgggag atgaccttca      660

cggccactgg ccagaggtac ttcctcaatc acatagaaaa aatcaccaca tggcaagacc      720

ctaggaaggc gatgaatcag cctctgaatc atatgaacct ccaccctgcc gtcagttcca      780

caccagtgcc tcagaggtcc atggcagtat cccagccaaa tctcgtgatg aatcaccaac      840

accagcagca gatggccccc agtaccctga gccagcagaa ccaccccact cagaacccac      900

ccgcagggct catgagtatg cccaatgcgc tgaccactca gcagcagcag cagcagaaac      960

tgcggcttca gagaatccag atggagagag aaaggattcg aatgcgccaa gaggagctca     1020

tgaggcagga agctgccctc tgtcgacagc tccccatgga agctgagact cttgccccag     1080

ttcaggctgc tgtcaaccca cccacgatga ccccagacat gagatccatc actaataata     1140

gctcagatcc tttcctcaat ggagggccat atcattcgag ggagcagagc actgacagtg     1200

gcctggggtt agggtgctac agtgtcccca caactccgga ggacttcctc agcaatgtgg     1260

atgagatgga tacaggagaa aacgcaggac aaacacccat gaacatcaat ccccaacaga     1320

cccgtttccc tgatttcctt gactgtcttc caggaacaaa cgttgactta ggaactttgg     1380

aatctgaaga cctgatcccc ctcttcaatg atgtagagtc tgctctgaac aaaagtgagc     1440

cctttctaac ctggctgtaa tcactaccat tgtaacttgg atgtagccat gaccttacat     1500

ttcctgggcc tcttggaaaa agtgatggag cagagcaagt ctgcaggtgc accacttccc     1560

gcctccatga ctcgtgctcc ctccttttta tgttgccagt ttaatcattg cctggttttg     1620

attgagagta acttaagtta aacataaata aatattctat tttcattttc tgcaagcctg     1680

cgttcttgtg acagattata cagaattgtg tctgcaggat tgattatgca gaatactttt     1740

ctctttcttc tctgctgccc catggctaag ctttatgggt gttaattgaa atttatacac     1800

caattgattt taaaccataa aaagctgacc acaggcagtt acttctgagg gcatcttggt     1860

ccaggaaatg tgcacaaaat tcgacctgat ttacagtttc aaaaactgta ttgatgacag     1920

tagtaccaaa tgctttaaaa actatttaac ttgagcttta aaaatcattg tatggatagt     1980

aaaattctac tgtatggaat acaatgtaat tttgaatcca tgctggctct gatggctctt     2040

attagtctgt atttataaag gcacacagtc ctattgtagc ttatctttcg ttattttact     2100

gcagagcatc tagacaactt agtccctcca gcgggaaagt agcagcagca gcattagtca     2160

caggtcttac actacagatc ttgtgaaaga gaccagtttg gtactaatta tgagcatttt     2220

attcaaacaa aagtttttga aatattacaa ctggggattt aaaaaattgc agcttagaat     2280

ctgatggttt ttttttttct tgatgttgtt tgtttgtttt tgagatcgag ttttgctctt     2340

gttgtccagg ctggaatgca atggcacaat ctcggctcac tgcaacctct gccttctggg     2400

ttcaagcgat tctcctgcct tagcctcccg agtagctggg attacaggca cctgccacca     2460

cgtccggcta attttttgta ttttgagtag agacggggtt tcaccataat ggtcaggctg     2520

ttctcaaact cctgatctca ggtgatccac ccatctcggc ctcccaaagt gctgggatta     2580

ctggcgtgag ccaccgcacc cggccttgat gtttatttta taaagcactg taattttgta     2640

gctgatgaca aaaggcagcc aaatgttttt gataaatcag tggcaactgt atttttgtct     2700

tttgaaataa ctctgaaaac atcaggacaa catagatttc aacctgatag cacaccacac     2760

acagtgagct gttgcttttt aaattctgaa gccttgtcag gtttgcttcc tagatttcaa     2820

gtgtttaaaa taattctatc tatgaaactg aaggatgaag cagatctctg actgacatgt     2880

aaaaaaaaat gccctttgag ggtgtatggt ggagataaat gtttctgaat tcagtaaaat     2940

tgattcctaa gtatattatc ctaatcctgt ttgctacagt tggtataaaa aggcatgaaa     3000

tatgtattca atacctctta tgtaaccaaa accattttta attagctttt aaggactgag     3060

agagcatcat gttcaactgg catgcagtct gcctgcattg ccaatgaagt cctcaactgt     3120

ttaatatttt gaactaatat tatttataat ctatgaattt aatctttttt gaaagacttt     3180

aataatttga gtctctgaga ggatactttc aatttccatg ggggacttat ttgttgggga     3240

tcttaaataa gattcctttt gatctaccgg aatatacatg tacagagtac attggatcat     3300

gttggaaaga aggcaagtga aaaggtcaga gatgaagtag caaagttatg gaatatcgtg     3360

gaaaggatac tagttgtgaa atggaaagag acaagttata gtaccccaaa agcaaaacaa     3420

gcaggagatg caagagatgc cccaaaagga caaagcaaca attttctgtt gccaccttta     3480

taccggaaga ctctgttgta gaagaaaaga aggctttggt gcaccttatg tgggaggagg     3540

aggggcaggg catgctgatg ctgagcgtac aggcagacaa gagcgtagcc tgctgttgcc     3600

tccatcacta tgaaatgact tattttacct gaaggaccca tggtttatgt tcctctaatt     3660

cctttcactc tccctaagcc ctctgagaga gatgaagata gatgatttta ttgctactaa     3720

attgaaggga gcactatttc tttttgtctt ttgttagcaa aaaattgcaa aaagaattgt     3780

acattcttgc taaaaataaa taaataaata aaaaattaaa aaaacaaggg acctaacaaa     3840

actcagcagt gttactgtat ttttaaaaaa tatttttata gactcatttt caggttatta     3900

aatgtaagag aaacagatac ccctcttttt taaagtaggt aaatcattga tgatttatat     3960

taccaatttt tagaagtaat tttctagtaa gcttgtggca tcagaaaata ctagaagatt     4020

tttttagtta aattagttag aacatttatg aatgaatata ataaatattt tttcagaata     4080

aaatatggac cctttgtgtt tactaataga taaagccaga tataattttt tgtttttaag     4140

gccacaaaat atggcctttg ttaaagaaca ctaaagttag aaatctaaag ttagagcaac     4200

tttttaatgg ctatttccta ttattgtaag tgttaaaacc cctgcagaat tcttgataag     4260

gtgctattta tactatattt cttattataa gataactgtc tttagtcttc ttagtactag     4320

tctttttagt actaaatcaa tcagtaaaca tcatcatttc accccaaaat tttgtcacag     4380

aaaaggcgta tcaaatgaaa aataatttca gagatctttc tttcaagata ttttttcctg     4440

ataaaataca ttgtcttgaa gtaaatacat tgtcaaaacc taattgcaat tctgttaaat     4500

ctaagtaatt tttagacagt gtttcaccgt attatttagg atgtgaaatg ccatttcttt     4560

cactgattac accatataca ggaaacaggt aaaacagtga aaactttatt gtgctggttg     4620

atgccaactt ggttgaaaag ctctctgcag aagaagtgat ctagactgac agaagtgttg     4680

ctaattacaa gttgtgttct catgacgtaa ttagaaagta acttctcaaa gtacaacttt     4740

tatgaaaaaa ataagctgtt aaaaaaagga aatcgtaggt taatttaatt gggaaaatgg     4800

gcaattgaca gagaccattt tcctaacaca tatatgtgct agtactttaa ctttttaaaa     4860

ttttacttct acgttttgta atataaaaat ttctatttta agtttagaat gttatacgta     4920

ccgaaagtat gcagccaaat cgatcagatc aaaccatttt acctggagtt tggtactggt     4980

ttttacttct ctgaatctgt ataagaaaaa taaagacaat tgaacttcca                5030


<210> 3714
<211> 849
<212> DNA
<213> Homo sapiens

<400> 3714
attttaggcg ccattttcga gtgaaggacc cggagccgaa acaccggtag gagcggggag       60

gtgggtacta cacaaccgtc tccagccttg gtctgagtgg actgtcctgc aggcacgtct      120

agattttccc acttacatag gtcttgttaa gaaaccagtc ctgccttctt gccactcgtg      180

tctttcgatg gctcccttcc cgaagtcccg ctgcctctaa gcggagtgtt aagcggggct      240

ctcggaagcc ggtggaccga gatttccccg ggtggggcgg gcgcggtgta gcggcccgcg      300

ggctgacttg ctcccggctg tcccccggcc ccagcgacca tgccccgtaa aggcacccag      360

ccctccactg cccggcgcag agaggaaggg ccgccgccgc cgtcccctga cggcgccagc      420

agcgacgcgg agcctgagcc gccgtccggc cgcacggaga gcccagccac cgccgcagag      480

actgcaagtg aggaacttga taatagaagt ttagaagaga ttttgaacag cattcctcct      540

cccccgcctc cagcaatgac caatgaagct ggagctcctc ggcttatgat aactcatatt      600

gtaaaccaga acttcaaatc ctatgctggg gagaaaattc tgggaccttt ccataagcgc      660

ttttcctgta ttatcgggcc aaatggcagt ggcaaatcca atgttattga ttctatgctt      720

tttgtgtttg gctatcgagc acaaaaaata agatctaaaa aactctcagt attaatacat      780

aattctgatg aacacaagga cattcagagt tgtacagtag aagttcattt tcaaaagata      840

attgataag                                                              849


<210> 3715
<211> 623
<212> DNA
<213> Homo sapiens

<400> 3715
gggggcgact ttgtggggag cctagctgct gctgggcgtt taccgcggga gcccttagcg       60

gtctggagct tatgtggaga agtcgctgtg aagccaccta taaatccatt tactgaattt      120

atggagaagg ctgtaaatga tggaagtcat tcagaagaac tcttttgcca tcttaaaact      180

atatcagaga aagaagattt accacggtgt accagtgaaa gtcatctcag ctgcctgaag      240

caggacattc taaatgaaaa gactgaattg gaagcaacac ttaaggaagc ggagttggta      300

actcattctg tagaattgct tttgccacta tttaaggaca ccattgaaaa gattaatttt      360

gaaaatgcga atctttctgc attgaatttg aagatttctg aacagaagga aatattaata      420

aaagaattag acaccttcaa aagtgtaaaa ctagctttag aacatcttct tagaaagaga      480

gactacaaac aaacaggaga caatttatcc agcatgttgc tagaaaatct aactgataat      540

gaaagtgaaa atactaatct taagaagaag gtatttgaaa aggaggccca tatccaagaa      600

ctttcttgtt tgtttcagag tga                                              623


<210> 3716
<211> 3296
<212> DNA
<213> Homo sapiens

<400> 3716
gagcaactgc cggcctccgc ccccagccgc agccggtcac tggcggcgcc ttccgcgcca       60

agcttggggg ccttttcggg gtcctacatg gcacggcttc cgacccccgg cccgggacgg      120

ggctcgcagg ccccagaggg gcaggctgga gaaggaggag gttaggtgtc ttcaggaggg      180

ttgctgagcc caaggacgcg ccatcgccgc ggagaaggag ccggacccct tgggcggagc      240

gcccaatgtg tggtccctca cgccgtcccg caccttgctt tttagggttc tttttccgct      300

ttctgagccc ttttatacct tacgtttaga aggggaaaat catcctccca caccttctcc      360

ccgacttttt gccttttttg tcttgaagtt acccaaaggt ctgtgtattg ttctcagtgg      420

tcccaagaat tactcgaata tagttgtttt tctgagggag gatggatgga gataactatc      480

ctgatcccag tgtcactttt taaggcattc gcttcaagag acaagcagtt tagaatcagg      540

cagaactgga ttgcaaaatt tatgggcaga ccggaaaatg tctaatcaac aggagaagta      600

tgaagctcag aatatagtca attcaacaga agagagtgat gatgcttttg atactgtcac      660

tattccagtt ccctcagaag agcctcaaga gtcagatcaa actgaagagc atgaatctgg      720

aatagaacaa ttcagtgaga gccatgcaat acatgttgag gagcagagtg accaaagctt      780

ttcaagcctg gaaccagaca atgaacaact catggaagag gttatatcac caagacaagt      840

ttcatatact ccgcaacatc atgaaaagca atatgcaatg cagaggccaa atgatgatag      900

tttggcattt ctggataaaa taaagtctgt aaaggaatct ttgcaagaat cagtggaaga      960

ttctctagca acagtaaaag ttgtacttat tccagtgggc caggaaattg taataccttt     1020

taaggttgat accattctta aatatcttaa ggaccatttt tcacacttat taggtatccc     1080

acattctgta ctgcagataa gatactcagg aaaaattctt aaaaataatg agactctagt     1140

acaacatgga gttaagccac aggaaattgt acaagtggaa atcttttcta caaatccaga     1200

tctgtatcca gtcagaagaa tagatggatt aactgatgtc tctcaaatca taactgtcac     1260

tgtccaaact ggacttgatc aataccagca ggtacctgtt gagattgtca aatctgactt     1320

tcacaaacca tttcttggtg gattcagaca taaagtaaca ggagtagagt atcacaatgc     1380

tggaacacaa actgtaccta aaaggattcc cgaaagactc agtatatttt gtagggatac     1440

gcagacagtt tttcagaaaa aaaatctcca acaaactaca aatacaacat ccacacagat     1500

gactaacatt ggtgtatatg tatcaaatat gactgataaa ctggtaacac caggaaagta     1560

tttttcagca gcagaatacc atgctcaaag actaaaggcg gtgatagtga tacagactta     1620

ctacaggcaa tggcatgcta aaatcttcgt agagaattta agaagacaga aaagcttaag     1680

actggaatgg gaaacacagc aagaactaag gaagataaga gaaaaagaag aatggataaa     1740

attggactat caccggaggc ataatcctaa aacaaatgaa gattttgaat ttctttataa     1800

tgcattagaa ttctggcggc aagaagaact tacacgtatt aaccaatctt ttactggagc     1860

tgaaaggaaa gctgctctgt gtgaacttct ggaaaaagag actcagataa ttgcttccat     1920

tgggagacat agatacattg cttatatggc aaatcaggaa gcagcaatac aagctttttt     1980

ggataagtgt tcagctccaa aaatatggag aacccctaat ggcaaaacaa ttgagatgga     2040

tacgcagttc accatcagag ccagagagct gcaaaatatc tataagtgca ttatgctgaa     2100

aaatatctcc caagatgaga ggctggatgt gctgttaact cttaaacaca ctgtaaagga     2160

acatgaatgt aaactaactc aggaaattct agaattgatt gacagagagg ttgaccttat     2220

gatgagagga gtcaaacatc ataaccttga aggactcaga aaaagaattg cgacactctt     2280

ttttcattat atcaaaacac ctctgtttaa tcctgaagtt gcaaaatacc ttaaggtccc     2340

tcaagaccca ttgaaatttt ataagaagat ttacttttgc cacagttgcc agctttattt     2400

gccttctaca gaattttctg tatcatccac ctcacgccgc atataccggt gtcgtaactg     2460

cattaacctt cagaatgagg ctcaaaaacg agaatcattt ttgaagtaca aatgtttact     2520

tcaacagctc tactatacag aagctgatta tgaagatgat tctaaaattg ctttcttgat     2580

gcagctacaa gacattcagt acctgacaga gaacatctgg gcgtcccagt cagtcctcag     2640

tgcttgcgac aatctcagtg atctggtcat ggtcagatgg aataaatccc tggagtggtc     2700

cccctggaac tgcattcttc ttaccaaaga tgaagcagct gctcatctca agctaacaag     2760

tattgaagag ggatatgaac gctcatttat tcacaagatc aaacacaaac atatcctggc     2820

taagaactat ttttctcagg ttccagtgct ggcttcattt atacttgatg atggtgaaat     2880

tgatgagatc agatggaagt atcactcaga cacaacacct aagattatag aatcccagag     2940

gcctcctcat taggtgatcc aggagtattt gtttgatgat cggcattttg ttcactgcta     3000

atagggtaat acagaggtca cagagtatgg aaatggaatt taatctgttt attgattttg     3060

ttttttgttt ttcatagtat tttgagttat ataaagagaa aacatttcta tataagtaag     3120

tattctttgt taggaagttg gtgctaaatt gaaatgcaat tttgttactg aaattaatat     3180

tttggggtaa agaaaacatt ttaaaatgtg ttttcacatt aaatttttta aattttttca     3240

agtatattag agttaaaatc taacaaacag ccaaataaaa actagacaac tttcaa         3296


<210> 3717
<211> 2291
<212> DNA
<213> Homo sapiens

<400> 3717
aaaaggggcg ggcgagcacg gcccgcgggc ggcgttcgct ggagctggtg gaccgggcgg       60

ctgaccgagg ggcggacgcg cggcggggca gaccgctggg gactgcgggc ggcgctgtgt      120

ccgtcgccat gacagatcag acctattgtg accgcctggt gcaggacacg cctttcctga      180

caggccatgg gcgcttgagt gagcagcagg tggacaggat catcctccag ctgaaccgtt      240

actacccaca gatccttacc aacaaggagg cggaaaagtt ccggaacccc aaggcatcct      300

tgcgtgtgcg gctctgtgac ctcctgagcc acctgcagcg gagcggtgag cgggactgcc      360

aggagttcta ccgagccctg tatatccatg cccagcccct gcacagccgc ctgcccagcc      420

gccacgctct gcgtaagttc cacatcacca accatgcatg cttggtgctg gcccggggag      480

ggcaccccag cctgccgttg atggcatgga tgtcctccat gaccacccaa gtctgctgca      540

gcccaggcct ggcatcccct ctcgcctcag cccctcccca gaggccaccc tctggccccg      600

aggggagagt gtggcaggca caggcagtgc agatgttggt ctctgtctcc cactttctcc      660

cccttcctcc gtctctctct catggcagtt ttcacacagc atggggcatc ttatacgtcc      720

actcttgccc ttccttttct aacctcattc cacggggatc ccttcatgtc tgtgtggaca      780

gcaaccttgt tcccacagct gcatggcgct cctaggcggt cccagctgga attacccaac      840

cccatgacgg accctttcat tgcagcgatc tgcacacgtg tgggtgtttc cataggacat      900

tgtcaggcac ggatggctgg tccgaagcac gtgcatttca gttttgaggc tcctgtcctc      960

aggcagtgtg gactcaggcc ctgggagtca tgtggatgcc agtagcctgg gcccacagag     1020

ctgctgggat gtggggggca tatcaagttg aagatggcaa ctctgatctg acgcctctgt     1080

gctcagggcc cctggaggag gggctactgc cccttggccc ttagacaaca ggacagagac     1140

cagagggact gggcggcttg tcccaggcta ctgggctgtg gtctctgacc ccctggaggc     1200

ctccccacgc ctcacagaac acagtgcaga cggtgggcgg ggagagctcg aggggaggcc     1260

cagccctgca ggtgggactg gctctccctc cccagccacg agtatgccac agggggcttt     1320

caaaaccagg cagggccaag ccttggcccc actggaggta gagcaccttc tgtggctccc     1380

gggtgccttt aggcccgtcc aggagttgga gcagaggaga agacccagac tgtgcatagt     1440

tccctgagga gggctagcct caggtgccac agcctggttc ggcctggcgg ccccaggagg     1500

cagcagcaac cttgggcttc ctgcggggtg actaccttgc cctccggccc tgcccgttga     1560

ctaactatgc tctgtggttt tgtttccaga gaactcagat tgcacagagc tagactcggg     1620

cagccagagc ggcgagctga gtaacagggg taacacctcc ctgctgcccc tccctctctc     1680

tccctctctc tccctctctc tttaccctcc ccagggctcc atctccgcct caggggcttc     1740

tccaccccaa gtctggctcc attcctggcc ttctgttggt gacagacccc ccccctaagg     1800

tgctcgtttg ggggctcttc aggcagcacc tcagcctggc acccccactc ccctgcgcag     1860

cccccaggcc tcaggacccc acccctctga ggcccagggg agccctgttc acgctggttt     1920

ctccccagga cccatgagct tcctggctgg cctgggcctt gctgtgggac tggccctgct     1980

cctgtactgc tatccgccag accccaaggg cctgccaggg acccggcgcg tcctcggttt     2040

ctcgcctgtc atcatcgaca gacatgtcag ccgctacctg ctggccttcc tggcagatga     2100

cctagggggg ctctgacaga ccctggaccc agggcctcac ctgccactca accaaagagt     2160

cctcgagccg gcccgccaag gggactgctg cttctttttc taaatgcata tttttcatta     2220

tttataattt gtgtaaaaaa cacaccttca ccttacaagg tgctgaccat attaaatgtt     2280

caggttctct c                                                          2291


<210> 3718
<211> 2390
<212> DNA
<213> Homo sapiens

<400> 3718
aattgtaaat atctttaatg cttggaggtt aagagaaact tgaactttgt agtaatggag       60

attaaagcta ttctcaagat taggtatacc tattcaataa aagaaaggaa tatttgggag      120

tattggggat aagagaagct agacattgtg aattcaagga aaaagaatta tgagaggagg      180

atgcatttta gtttattttg tgattaaaat ttttttagtt tttgttgttt tgacatgtga      240

cactgtaatt ttggctataa taaatgacag aatgtatcat ttggtatatt ggttagggtt      300

taggtagaaa attttttcct ttatatagtg agtggtagcg tatacaatgt ttgctcactt      360

cggcaaagag tagctttagt tttctgatta gttataatag tgatgcttcc catcatttga      420

tatgccttaa agtagtattt tactcttgag gtattccttt aatccttagg tcttggagta      480

ctttatagat ggtcattatt ttttatgatt cctctgaaac taaaggcaga gaatcaccca      540

agcattacaa aaatgttgag caaaataaaa attaaagctt ggttcctgaa cattatctgt      600

tttctggtac cacttaagaa gtttcaaagg atgagaagac taagactaat aactattttt      660

ttcttcatct tttctttcag tggcaggatg tggaaattga tttttttttt attttcacct      720

taactgaata cttacttaat tcttttgttt aaattgcaga atgccgggtc taagttgtag      780

attttatcaa cacaaatttc ctgaggtgga agatgtagtg atggtgaatg tcagatccat      840

tgctgaaatg ggggcttatg tcagcttgct ggaatacaac aacattgaag gcatgattct      900

tcttagtgaa ttatccagaa ggcgtatccg ttctatcaac aaactcatcc gaattggcag      960

gaatgagtgt gtggttgtca ttagggtgga caaagaaaaa ggatatattg atttgtcaaa     1020

aagaagagtt tctccagagg aagcaatcaa atgtgaagac aaattcacaa aatccaaaac     1080

tgtttatagc attcttcgtc atgttgctga ggtgttagaa tacaccaagg atgagcagct     1140

ggaaagccta ttccagagga ctgcctgggt ctttgatgac aagtacaaga gacctggata     1200

tggtgcctat gatgcattta agcatgcagt ctcagaccca tctattttgg atagtttaga     1260

tttgaatgaa gatgaacggg aagtactcat taataatatt aataggcgct tgaccccaca     1320

ggctgtcaaa attcgagcag atattgaagt ggcttgttat ggttatgaag gcattgatgc     1380

tgtaaaagaa gccctaagag caggtttgaa ttgttctaca gaaaacatgc ccattaagat     1440

taatctaata gctcctcctc ggtatgtaat gactacgaca accctggaga gaacagaagg     1500

cctttctgtc ctcagtcaag ctatggctgt tatcaaagag aagattgagg aaaagagggg     1560

tgtgttcaat gttcaaatgg agcccaaagt ggtcacagat acagatgaga ctgaacttgc     1620

gaggcagatg gagaggcttg aaagagaaaa tgccgaagtg gatggagatg atgatgcaga     1680

agaaatggaa gccaaagctg aagattaact ttgtgggaaa cagagtccaa tttaaggaac     1740

acagagcagc gcttcctggc tgtaaatcct agacttgaaa gttttccagt attgaaaact     1800

tcaaagctga atatttttta tttctaagta tttaaatgtt ctaacagatc agaacatgaa     1860

atgccctcct aaatgtcagc tgttgtcaca cagtagctcc aacactttga gcatttttaa     1920

gggagtggcc tcatttcact agagacaaat ctttaagaat agttctaaaa ttgggcttgt     1980

gatttccatt tctgatgtct ccagattggc acccctttct agttcaatgc ctcacgagat     2040

ttgccagggg catccaaggc aaacaatccc aatctttcta tataaaatgt attcaagcaa     2100

acatcaaata aatttctggg atatttaact ataggcttct tccttcttgt caccagttaa     2160

aagcatttta atactaagac cctaattctt ttatctttat tttagtcttg atgtggaact     2220

gtaggagcag gtgaataaag gatctctata acagatcctt tcaaaagaag agttttagag     2280

aaaataaatt taactttaac cacagtgaaa gttgaccctt agcgggacaa agccttaaaa     2340

tgcattgaaa gaattagatc ggttctgtgc cttttatcta tttgagattg                2390


<210> 3719
<211> 1603
<212> DNA
<213> Homo sapiens

<400> 3719
agtccgggag ctgctgcggc cgcgctgtct gcttctcctg cgcctccttt tcgcccagca       60

ctagcgcctt aggccagctc gggggatgtg agagccgaag cccttagact gccaggcaca      120

gagtcgggtc gggatttgtc agccaagcct cggctccagc tccgcaatct cgggactcac      180

ccgagcgacc caggcccgac ggcaaatgaa tccggcctcg gcgccccctc cgctcccgcc      240

gcctgggcag caagtgatcc acgtcacgca ggacctagac acagacctcg aagccctctt      300

caactctgtc atgaatccga agcctagctc gtggcggaag aagatcctgc cggagtcttt      360

ctttaaggag cctgattcgg gctcgcactc gcgccagtcc agcaccgact cgtcgggcgg      420

ccacccgggg cctcgactgg ctgggggtgc ccagcatgtc cgctcgcact cgtcgcccgc      480

gtccctgcag ctgggcaccg gcgcgggtgc tgcgggtagc cccgcgcagc agcacgcgca      540

cctccgccag cagtcctacg acgtgaccga cgagctgcca ctgcccccgg gctgggagat      600

gaccttcacg gccactggcc agaggtactt cctcaatcac atagaaaaaa tcaccacatg      660

gcaagaccct aggaaggcga tgaatcagcc tctgaatcat atgaacctcc accctgccgt      720

cagttccaca ccagtgcctc agaggtccat ggcagtatcc cagccaaatc tcgtgatgaa      780

tcaccaacac cagcagcaga tggcccccag taccctgagc cagcagaacc accccactca      840

gaacccaccc gcagggctca tgagtatgcc caatgcgctg accactcagc agcagcagca      900

gcagaaactg cggcttcaga gaatccagat ggagagagaa aggattcgaa tgcgccaaga      960

ggagctcatg aggcaggaag ctgccctctg tcgacagctc cccatggaag ctgagactct     1020

tgccccagtt caggctgctg tcaacccacc cacgatgacc ccagacatga gatccatcac     1080

taataatagc tcagatcctt tcctcaatgg agggccatat cattcgaggg agcagagcac     1140

tgacagtggc ctggggttag ggtgctacag tgtccccaca actccggagg acttcctcag     1200

caatgtggat gagatggata caggagaaaa cgcaggacaa acacccatga acatcaatcc     1260

ccaacagacc cgtttccctg atttccttga ctgtcttcca ggaacaaacg ttgacttagg     1320

aactttggaa tctgaagacc tgatccccct cttcaatgat gtagagtctg ctctgaacaa     1380

aagtgagccc tttctaacct ggctgtaatc actaccattg taacttggat gtagccatga     1440

ccttacattt cctgggcctc ttggaaaaag tgatggagca gagcaagtct gcaggtgcac     1500

cacttcccgc ctccatgact cgtgctccct cctttttatg ttgccagttt aatcattgcc     1560

tggttttgat tgagagtaac ttaagttaaa cataaataaa tat                       1603


<210> 3720
<211> 613
<212> DNA
<213> Homo sapiens

<400> 3720
ggacccgccc tcaagttctg gacaccccgg gtgaagactg ttaacgcggc ggggattggg       60

cgcctgcggc agcttgtggg cggtacccga gggagagttc gagtttttat tggtgtggaa      120

attaaaagaa cacacatatt ttgactgggg ctttgatcaa ccaaatgcta aaaagccaca      180

taaagaagat ccctaatagt catttctcaa caattatata gtcaactgat gtaacaatgg      240

tactaatatt gggacgcaga ctaaacagag aggatcttgg ggtgcgtgat tccccagcaa      300

ctaagcgaaa agtttttgaa atggacccca aatctctgac aggtcatgag ttttttgact      360

tctcttcagg atcatcccat gccgaaaaca tactccagat atttaatgaa tttcgtgata      420

gccgcttatt cacagatgtt atcatttgtg tggaaggaaa agaatttcct tgccatagag      480

ctgtgctctc agcctgtagc agctacttca gagctatgtt ttgtaatgac cacagggaaa      540

gccgagaaat gttggttgag atcaatggta ttttagctga agctatggaa tgttttttgc      600

agtatgttta tac                                                         613


<210> 3721
<211> 1915
<212> DNA
<213> Homo sapiens

<400> 3721
atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac       60

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      120

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      180

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      240

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      300

ggccacagta gggaagaggc tggactatat cacagctgaa atatttctga ggacaatccc      360

agacccagga gatgttccag actcattttt ctgatattca gagagggcaa gagtcttggc      420

ctatgtcaca cagcagagtc caggactcca gaactccaac ctagcactct ggccagaaag      480

tcagccagag gaaggaaaac tgggaatgaa gagtcagagg tgagaagcta aagtcatgat      540

ctcaccaagg gatcaagagg tcgatattgg cggcttgtga cggtaaacac ggcaccatcc      600

tcctcctcat cccagacgga cacaggggcc tggaggagca aggaagggga agtcagacag      660

ttccacacca ccccccattg ccctcagcct tcaccccagg ccctgctcct ccctctgtac      720

ccctcacctg tggtggcagg gcatagtacc agcgagtgcg aggaagggtt gggggagctg      780

gtgaccccag gtctccccca ctggggccca gacagcccca ccccagccgc ctcagggccc      840

cggtggagtc gaaggggctg cagtggaggc gtggatggag tacaggaatt ctgatcctgg      900

agacccccaa agccccttct ccccagagct gaacccacac acgacagaga agcagggtac      960

aaagggcagg agagggaagc gagaggcagc aagccagagg cagcgactag gggtagctga     1020

aacctcagtc caggcactgc cgcatgcccc gcccctcccg gccaaggact ataccagccc     1080

agagaattag tctttttcag gacccctttc accctggtcc ctcgggtagc gcctccacta     1140

tctcagccct aagggacccc cgaaggtagc agctccaatc ccagtacagg aaggaaaagg     1200

ggaagtggga tgataggggg ttgggggcgg tagactcaga gagtcacgtg gccccagccc     1260

ctcccccgac cgatcccgaa aaaccagccc tgccagtcaa cctgccctca cctaggatct     1320

ggacctagga gtttagggcc tcggggcccc aaatccaaat tctggcccct cctgaggccc     1380

gaaatcctgc tcctggccac caccattaat ccctaatgaa aacagatgac cactctctac     1440

ccaccctagg atctttcctc caggtcccag aaccgtggct tcccggcctc tacccaggac     1500

cggggcgggg cgggggggcg gggggaaggg ggagagaggg aaggaggggt cacgaaatct     1560

gagggttccc tccccaatcc cagagtcaga ggagctggtt actgtggaaa caaacccctc     1620

cccgccaaac aaaaacaagg agggagacag ggaccaagac acgactgctc agagaggtag     1680

gcacactcag gcaggcagag gtggagggcc aaagacccgc agggacagga cagccagcca     1740

gaagttccag gcaggaacag ggcaggttcc tgcgggcagg tcctgagtca cactgacaga     1800

gaaccacgga gacgccagga ctccccgcag cagagaaacg ggccgacacc cagggaggcg     1860

cgagaataac tgaggcaagg aggaggagat gtagggaccc agagacaaga gaaaa          1915


<210> 3722
<211> 574
<212> DNA
<213> Homo sapiens

<400> 3722
gttgtgagct gcggcagaga ctggtggctg gaggagacgc cggcgctgga gagtgcgctg       60

cgccgcccgc cgctgaggga ccgcggggtt agccactgct ggctgcttcc agtgttcgcc      120

gagaggaagc ccgggggagt gcgaccgcct caaatccagc cttcttgttt ggtgggacga      180

ccgtcggttc tgtccgggag gaatgacggg gtcaaggtgt ggaaattaaa agaacacaca      240

tattttgact ggggctttga tcaaccaaat gctaaaaagc cacataaaga agatccctaa      300

tagtcatttc tcaacaatta tatagtcaac tgatgtaaca atggtactaa tattgggacg      360

cagactaaac agagaggatc ttggggtgcg tgattcccca gcaactaagc gaaaagtttt      420

tgaaatggac cccaaatctc tgacaggtca tgagtttttt gacttctctt caggatcatc      480

ccatgccgaa aacatactcc agatatttaa tgaatttcgt gatagccgct tattcacaga      540

tgttatcatt tgtgtggaag gaaaagaatt tcct                                  574


<210> 3723
<211> 2068
<212> DNA
<213> Homo sapiens

<400> 3723
agcggcgcgg agactgcggg gcgggccatg gcggcgaacc tgagccggaa cgggccagcg       60

ctgcaagagg cctacgtgcg ggtggtcacc gagaagtccc cgaccgactg ggctctcttt      120

acctatgaag gcaacagcaa tgacatccgc gtggctggca caggggaggg tggcctggag      180

gagatggtgg aggagctcaa cagcgggaag gtgatgtacg ccttctgcag agtgaaggac      240

cccaactctg gactgcccaa atttgtcctc atcaactgga caggcgaggg cgtgaacgat      300

gtgcggaagg gagcctgtgc cagccacgtc agcaccatgg ccagcttcct gaagggggcc      360

catgtgacca tcaacgcacg ggccgaggag gatgtggagc ctgagtgcat catggagaag      420

gtggccaagg cttcaggtgc caactacagc tttcacaagg agagtggccg cttccaggac      480

gtgggacccc aggccccagt gggctctgtg taccagaaga ccaatgccgt gtctgagatt      540

aaaagggttg gtaaagacag cttctgggcc aaagcagaga aggaggagga gaaccgtcgg      600

ctggaggaaa agcggcgggc cgaggaggca cagcggcagc tggagcagga gcgccgggag      660

cgtgagctgc gtgaggctgc acgccgggag cagcgctatc aggagcaggg tggcgaggcc      720

agcccccaga gcaggacgtg ggagcagcag caagaagtgg tttcaaggaa ccgaaatgag      780

caggggtcaa catgtgcttc cctccaggag tctgccgtgc acccgaggga gattttcaag      840

cagaaggaga gggccatgtc caccacctcc atctccagtc ctcagcctgg caagctgagg      900

agccccttcc tgcagaagca gctcacccaa ccagagaccc actttggcag agagccagct      960

gctgccatct caaggcccag ggcagatctc cctgctgagg agccggcgcc cagcactcct     1020

ccatgtctgg tgcaggcaga agaggaggct gtgtatgagg aacctccaga gcaggagacc     1080

ttctacgagc agcccccact ggtgcagcag caaggtgctg gctctgagca cattgaccac     1140

cacattcagg gccaggggct cagtgggcaa gggctctgtg cccgtgccct gtacgactac     1200

caggcagccg acgacacaga gatctccttt gaccccgaga acctcatcac gggcatcgag     1260

gtgatcgacg aaggctggtg gcgtggctat gggccggatg gccattttgg catgttccct     1320

gccaactacg tggagctcat tgagtgaggc tgagggcaca tcttgccctt cccctctcag     1380

acatggcttc cttattgctg gaagaggagg cctgggagtt gacattcagc actcttccag     1440

gaataggacc cccagtgagg atgaggcctc agggctccct ccggcttggc agactcagcc     1500

tgtcacccca aatgcagcaa tggcctggtg attcccacac atccttcctg catcccccga     1560

ccctcccaga cagcttggct cttgcccctg acaggatact gagccaagcc ctgcctgtgg     1620

ccaagccctg agtggccact gccaagctgc ggggaagggt cctgagcagg ggcatctggg     1680

aggctctggc tgccttctgc atttatttgc cttttttctt tttctcttgc ttctaagggg     1740

tggtggccac cactgtttag aatgaccctt gggaacagtg aacgtagaga attgttttta     1800

gcagagtttg tgaccaaagt cagagtggat catggtggtt tggcagcagg gaatttgtct     1860

tgttggagcc tgctctgtgc tccccactcc atttctctgt ccctctgcct gggctatggg     1920

aagtggggat gcagatggcc aagctcccac cctgggtatt caaaaacggc agacacaaca     1980

tgttcctcca cgcggctcac tcgatgcctg caggccccag tgtgtgcctc aactgattct     2040

gacttcagga aaagtaacac agagtggc                                        2068


<210> 3724
<211> 681
<212> DNA
<213> Homo sapiens

<400> 3724
aaactcctgg tacctaagca ccgatctgcc ttggagaacc tgattctgag actccagcag       60

gatgtcttat caacagcagc agtgcaagca gccctgccag ccacctcctg tgtgccccgc      120

gccaaagtgc ccagagccat gtccaccccc gaagtgccct gagccctgcc caccatcaaa      180

gtgtccacag tcctgcccac ctcagcagtg ccagcagaaa tgtcctcctg tgacaccttc      240

cccaccctgc cagccaaagt gtccacccaa gagcaagtaa cagcttcagg attcatcagg      300

agcatgaaag gataaggata attggctcac ctcgttccac agctccacct gcatcttctc      360

atcaaagcca tccagggata cacagggagc ttctttcctc ttagcctgtg atcggcctgt      420

gatgatctct gatagcaaaa ggttttcttt ttgaggctgc catactgcca ctgtccaggt      480

ggagactgag caaaggaagt cctgggctgt gccagctccc agagcttcag aagaaagagc      540

agctctctcc ctgggaacca ttagagaatt ctgttgatgt tttctgtgtc tgtctgtccc      600

ctgggcatga gcttccacca cctgtgcagt tgtcactttc ctttcactcc ctgaataaag      660

aatctatgca tatatatttg t                                                681


<210> 3725
<211> 2330
<212> DNA
<213> Homo sapiens

<400> 3725
cactgagccg ccgccgagga ttcagcagcc tcccccttga gccccctcgc ttcccgacgt       60

tccgttcccc cctgcccgcc ttctcccgcc accgccgccg ccgccttccg caggccgttt      120

ccaccgagga aaaggaatcg tatcgtatgt ccgctatcca gaacctccac tctttcgacc      180

cctttgctga tgcaagtaag ggtgatgacc tgcttcctgc tggcactgag gattatatcc      240

atataagaat tcaacagaga aacggcagga agacccttac tactgtccaa gggatcgctg      300

atgattacga taaaaagaaa ctagtgaagg cgtttaagaa aaagtttgcc tgcaatggta      360

ctgtaattga gcatccggaa tatggagaag taattcagct acagggtgac caacgcaaga      420

acatatgcca gttcctcgta gagattggac tggctaagga cgatcagctg aaggttcatg      480

ggttttaagt gcttgtggct cactgaagct taagtgagga tttccttgca atgagtagaa      540

tttcccttct ctcccttgtc acaggtttaa aaacctcaca gcttgtataa tgtaaccatt      600

tggggtccgc ttttaacttg gactagtgta actccttcat gcaataaact gaaaagagcc      660

atgctgtcta gtcttgaagt ccctcattta aacagaggtc aagcaatagg cgcctggcag      720

tgtcaagcct gaaaccaagc aataccgtca tgtttcagcc aagcccagag ccctaagatt      780

acaaacaact atggccggaa cctcctcagc tctccctctg cagagttccc taccctaaga      840

gaatgttacc acctgaacag tcctcggtga atctgagagg agaggatggg gtaaggcaga      900

agcaccagct gtactactag aagggagctt ttggtggtag atcccctggt gtctccaacc      960

tgactaggtg gacagagctc aaagaggccc tcttaccgct agcgaggtga taggacatct     1020

ggcttgccac aaaggtctgt tcgaccagac atatcctagc taagggatgt ccaaacatca     1080

gaatgtgagg ccaaccttct atcagagtta aacttttgac aagggaacaa atctcaaact     1140

gatccatcag tcatgtagct agctgtagag cttgcaactt aatagcagca gctgcccaat     1200

gccatgtgaa gtaacaaact ggtttttggt ttttttttcc ccttcagttt taatgttatg     1260

tgtaatgtat ttaaaccctt atttaaataa aacttgtttt cagaaatacc tgacttgcag     1320

attatttata tatagtcgat cttgtgcata taaaggaacc atagaaatgg gcagtggagg     1380

attcgtccac acccacagct tctcaacggg cctgaatttg gccaagaaaa acctttatga     1440

gcttgtccct ctctggtcaa ctggtttttt gttcgtttgt tttttgagac aggtttgccc     1500

ttgttgccca ggctggagtg cagtggcaca atctcggctc actgcaacct ccacctcagg     1560

ttcaagcaat tgtcgtgcct cagcctccct agtagctggg attacaggca ccatgcccag     1620

ctaacttttg tatttttagt agagacaggg tttctccatg ttggccaggc tggtcttgaa     1680

cacctggcct caagtgatct gcctgtcttg gcctcccaaa gtgctgggat tacaggcatg     1740

agccaccatg cccagcaggt caactgtttt tgcaagcatt tagccagagt catgctgtgc     1800

tgttaatcag tgtcctggag aatgggttgc ttggaaatct tggcgccccc tcagtagtaa     1860

cagccttggt ttaagggcgc agagtggaga gtaaatgcaa gggctataac aagggcattc     1920

atgctgtggg ttaagatcca caaatcgcta ggaatgtgta tactctgggt agtaagtttg     1980

tagtattaga aggtttaatg acaagtattt gaagagctga agttaagtgt tgggaggcca     2040

tcccttatga aggacaatga atggcaagta aaagaccaag ttctgttcct gggtccatta     2100

atttagttaa aaaggcaaag ttctttcagc acacatatct gcatgcagtc acgtgctgcc     2160

taaggatgct tcattcaaca atgagcctca cagccgtgct acacaataag attataatac     2220

tgtattttta ctgtaccttt taacattgtg ttacaatggc ctacaagaag cttgtgtgga     2280

tggctttgaa tgtggcccaa cacgaactaa taaattttgc taaaacatga                2330


<210> 3726
<211> 2737
<212> DNA
<213> Homo sapiens

<400> 3726
attagctggg tgtggtggcg cgcacctcca ccagtagtcc cagctacacg gaaggctgag       60

gcgggaggat ggcttgagcc tagaagtggg aaggcagcag tgagccgtaa tcgactctgg      120

gcgacagagc aagctatcta tcgcttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaggtga      180

cttgcaccta cggagagctt ggagaaaaca cggacaagtg gaattttccc gcggatcagg      240

agtctaaaga ggcagtgtga aatcgctgtt gtgcgcttgc gcgcagtttc ccgcatgctc      300

agtagctgag gtagggatgc catccttctc aaaagactta ttgacagtgc caaagctcgg      360

tactggacac aacgagggac ctgggtctac gataacgcgc ttttgctcct cctgaagtgt      420

ctttggtcca acgttgttcc agagtgtacc atggcttcca gtaacactgt gttgatgcgg      480

ttggtagcct ccgcatattc tattgctcaa aaggcaggaa tgatagtcag acgtgttatt      540

gctgaaggag acctgggtat tgtggagaag acctgtgcaa cagacctgca gaccaaagct      600

gaccgattgg cacagatgag catatgttct tcattggccc ggaaattccc caaactcaca      660

attatagggg aagaggatct gccttctgag gaagtggatc aagagctgat tgaagacagt      720

cagtgggaag aaatactgaa gcaaccatgc ccatcgcagt acagtgctat taaagaagaa      780

gatctcgtgg tctgggttga tcctctggat ggaaccaagg aatataccga aggtcttctt      840

gacaatgtaa cagttcttat tggaattgct tatgaaggaa aagccatagc aggagttatt      900

aaccagccat attacaacta tgaggcagga ccagatgctg tgttggggag gacaatctgg      960

ggagttttag gtttaggcgc ctttgggttt cagctgaaag aagtccctgc tgggaaacac     1020

attatcacaa ctactcgatc ccatagcaac aagttggtta ctgactgtgt tgctgctatg     1080

aaccccgatg ctgtgctgcg agtaggagga gcaggaaata agattattca gctgattgaa     1140

ggcaaagcct ctgcttatgt atttgcaagt cctggttgta agaagtggga tacttgtgct     1200

ccagaagtta ttttacatgc tgtgggaggc aagttaaccg atatccatgg gaatgttctt     1260

cagtaccaca aggatgtgaa gcatatgaac tctgcaggag tcctggccac actgaggaat     1320

tatgactact atgcaagccg agttccagaa tctattaaaa atgcacttgt tccttaaagg     1380

aaagtttcat ttggccgggc gcggtggctc atgcctgtaa tcccagcact ttgggaggcc     1440

gaggcaggtg gatcacttga gctcaggagt ttgagaccag cctgggcaat atcgtgagac     1500

cccatctcta caaaaataca aattaactgg gcatcctgtc atgcgcctgt catcccagct     1560

acttgagagg ctgaagcaga agaatctctt gagcccggaa ggcagaggtt gcagtgagct     1620

gagatcgtgc cactgcactc cagcctgagt gacaggagtt aagccctgtc tcagaaaaaa     1680

aaaaaacaaa aacccaaaaa gtacttaaag tttcatttac ttagctagga gaaagacttg     1740

gttctcaaaa taatacattt taagattaat tgggtagaat tagagttcca cctttattca     1800

ttgttgagca gtgatttata tttagttatt atatttagga atagaaaata gaattaaata     1860

atttaacttg attaatcaac cagaccaatt ttgacgtctg gagaacttat aaactcaata     1920

tgttatattt gttttcctgt atttaggtgg agaaatgaga aaaagcttta gttccaattg     1980

acagttcagg tcaatgttca atgaacattc ctatcttcta aaccagattt ctcttttttt     2040

ttcctgagac ggagtctcgc tctgtagcct aggctagaat gtagtggcgt gatctcggct     2100

cactgcaagc tccgcctccc gggttcatgc cattctcctg cctcagcctc ccgagtagct     2160

gggactgcag gcaccgccac cacgcctggc taattttttg tatttttagt agagaaggtg     2220

tttcaccgtg ttagccagga tggtcttgat ctcctgacat cgtgatctgt ctgcctcgga     2280

ctcccaaagt gctgggatta caggtgtgag ccaccgcacc tggcctaaac cagatttctt     2340

tagggcacaa ttttttctgg aatctcactc ttgtttttca cagtaatttt aaaaacgttt     2400

ctactccaat taagaatata tatgatgtta ttatatatgc ttatgaaaca gatttatgag     2460

aaaagttttt tttaaataaa ttatttaatc ctagctcttt gttattcacc agctttttaa     2520

aaaagtgttt gaaaattata cattctcgac tttggggatt agtttattct tgtggcatca     2580

ttataaggct taattgtgga aagctaagta cttgcttcta ttccttccaa tgagagatta     2640

taacataaac tattaaaatt attctgctaa tatacctaga tttttatttt taggtctctg     2700

tccattgctt ttaattaaaa ttatctgttt tcaaatc                              2737


<210> 3727
<211> 3160
<212> DNA
<213> Homo sapiens

<400> 3727
gaggagcgat gggcagaacc agcacttccc tcaggcacta gacctgtcac gagtgaactt       60

agttccctcc tatactcctt cactctaccc taagaacaca gatctatttg agatgattga      120

gaagatgcag ggaagcagga tggatgaaca acgctgctcc ttcccgccgc ccctcaaaac      180

agaggaggac tacattccat acccgagcgt gcacgaggtc ttggggcgag aaggaccctt      240

ccccctcatc ctgctgcccc agtttggggg ctactggatt gagggcacca accacgaaat      300

caccagcatc cccgagacag agccactgca gtcgcccaca accaaggtga agctcgagtg      360

caaccccaca gcccgcatct accggaagca ctttctcggc aaggagcatt tcaattacta      420

ctcactggac gctgccctcg gccaccttgt cttctcactc aagtacgatg tcatcgggga      480

ccaagagcac ctgcggctgc tgctcaggac caagtgccgg acataccatg atgtcatccc      540

catctcctgc ctcaccgagt tccctaatgt tgtccagatg gcaaagttgg tgtgtgaaga      600

cgtcaatgtg gatcggttct atcctgtgct ctaccccaag gcttcccggc tcatcgtcac      660

ctttgacgag catgtcatca gcaataactt caagtttggc gtcatttatc agaagcttgg      720

gcagacctcc gaggaagaac tcttcagcac caatgaggaa agtcccgctt tcgtggagtt      780

ccttgaattt cttggccaga aggtcaaact gcaggacttt aaggggttcc gaggaggcct      840

ggacgtgacc cacgggcaga cggggaccga atctgtgtac tgcaacttcc gcaacaagga      900

gatcatgttt cacgtgtcca ccaagctgcc atacacggaa ggggacgccc agcagttgca      960

gcggaagcgg cacatcggga acgacatcgt ggctgtggtc ttccaggatg agaacactcc     1020

tttcgtgccc gacatgatcg cgtccaactt cctgcatgcc tacgtcgtgg tgcaggctga     1080

gggcgggggc cctgatggcc ccctctacaa ggtctctgtc actgcaagag atgatgtgcc     1140

cttctttgga ccccccctcc cggaccccgc tgtgttcagg aaggggcctg agttccagga     1200

atttttgctg acaaagctga tcaatgctga atatgcctgc tacaaggcag agaagtttgc     1260

caaactggag gagcggacgc gggccgccct cctggagacg ctctatgagg aactacacat     1320

ccacagccag tccatgatgg gcttgggcgg cgacgaggac aagatggaga atggcagtgg     1380

gggcggcggc ttctttgagt ctttcaagcg ggtcatccgg agccgcagcc agtccatgga     1440

tgccatgggg ctgagcaaca agaagcccaa caccgtgtcc accagccaca gcgggagctt     1500

cgcgcccaac aaccccgacc tggccaaggc ggctggaata tcactgattg tccctgggaa     1560

gagccccacg aggaagaagt cgggcccgtt cggctcccgc cgcagcagcg ccattggcat     1620

cgagaacata caggaggtgc aggagaagag ggagagccct ccggctggtc agaagacccc     1680

agacagcggg cacgtctcac aggagcccaa gtcggagaac tcatccactc agagctcccc     1740

agagatgccc acgaccaaga acagagcgga gaccgcagcg cagagagcag aggcgctcaa     1800

ggacttctcc cgctcctcgt ccagtgccag cagcttcgcc agcgtggtgg aggagacgga     1860

gggtgtggac ggagaggaca caggcctgca cgtggctgga ggacagtgtc agcaccacta     1920

gtgggggcag ctccccagtg aggtggctcc ctcctgcccc cctccccagg cccctctcga     1980

tcaccccacc cagacgccgg caagttgggg gaccctgcgt gtcccgagat caagatccag     2040

ctggaagcat ctgagcagca catgccccag ctgggctgtt agccgggcca ccccctctga     2100

aggtgaaact gagcagatga ggccacagaa gcacaagggg aaggtgccgt gtcaagccca     2160

ggcagacgag acctctgccc tgaagaccaa caccagcccg tgggctgccc cctgcctccc     2220

caccctcccc atggcccacc catctgggct gtctctgcag ggcagagccg tccagacctg     2280

ggatcaggga agctgctggc atcgtcccca cccccagcct gggggtctgg gctggggcag     2340

ggattgctca gtggaagcag gactgggggt ctggcttgcc ccctccctgg gcctccatca     2400

cccctgagca tccctctgga ctcagaggga acaaggtggg agagagagtt tgagacagct     2460

ccgtgtggag agcttagccc ctggaggcag cacaaggagg atgtgatatg tgggggagtg     2520

agcactgggt tgggagccgg gtcctggttt ccaatttggg ttctgctgtg tgactctggg     2580

caagtcactc tccctctctg ggcatgtctg ctacaaatgg acaagattat ttcagaggtc     2640

actgaagact gtgattacat gcacctgcct tagaaggtag gattttcttc ccagggacct     2700

cctatcaccc taccctgctt cttgaggtcc ctggagcccc aggtgggctg aggggcaggg     2760

agccggctgt gcccagtatg cctcctggac cctccagttc tgccacaggt ctgccgatgc     2820

cctgtccact gcctacacat gacagacaag taaccccctc atgggggatg gggacctacc     2880

tggctcctca gccagcaccc agcttaaccc ctgccatccc atgctgggcc ctccaggcca     2940

agagtctcag ctggccgaga gtccaggcct tgcctccccc gaccgccatg gagggggcag     3000

cccggcacag ctgctgggag cccttgtgtg tctggtcaca ctttttaggc gtcacgccaa     3060

aggccagcct cctggcccca atacccattt tggaagcccc tgtggccgtg tggatgtcgg     3120

taacagttgt ataaaataaa ttctatttat cgctattgta                           3160


<210> 3728
<211> 541
<212> DNA
<213> Homo sapiens

<400> 3728
aggcaggcca cggagatacc tcgtggaagg aggaacagca agtgcatggg ccgagtgtgg       60

gacttgcctg gtgtgctcaa ggtggaaggc tttagggcca ccatggcgca gcgcctggtg      120

cgcgtgctgc agatctgtgc tggccacgtg cccggtgtct cagctctgaa cctgctgtcc      180

ctgctgagaa gctctgaggg cccctccctg gaggacctgt gagggtggct ggcccctggg      240

ctgccccttc tcatggcttc gtgctgactc cataaacatt ctctgttgag gatgtccagt      300

cagggcttga caggcccagg ctcagcccgc cgtggctggg aaggttccct gcagtgccag      360

tgctgcagca gggagagctg ggcagaagca gcgagggggc ccagctggcg agactgtagc      420

cccctcccac tcccacactc actcttgcag agcctgtgtc tttaagcagc tggcgtgtta      480

catctccatt taaggtttcc tttgaacaaa aggtctgtgg ctaaaaaaag tttaaaaatc      540

a                                                                      541


<210> 3729
<211> 2505
<212> DNA
<213> Homo sapiens

<400> 3729
aatgctgccg tgcgccgcgg gagccagggg gcgtggggcc atggtggtct tgcgggcggg       60

gaagaagacc tttctccccc ctctctgccg cgccttcgcc tgccgcggct gtcaactcgc      120

tccggagcgc ggcgccgagc gcagggatac ggcgcccagc ggggtctcaa gattctgccc      180

tccaagaaag tcttgccatg attggatagg acccccagat aaatattcaa accttcgacc      240

tgttcacttt tacatacctg aaaatgaatc tccattggaa caaaagctta gaaaattaag      300

acaagaaaca caagaatgga atcaacagtt ctgggcaaac cagaatttga cttttagtaa      360

ggaaaaagaa gaatttattc actcaagact aaaaactaaa ggcctgggcc tgagaactga      420

atcaggtcag aaagcaacat tgaatgcaga agaaatggcg gacttctaca aggaattttt      480

aagtaaaaat tttcagaagc acatgtatta taacagaatg tatgacaaca tgtccacaat      540

ggtgtacata aaggaagaca agttggagaa gcttacacag gatgaaatta tttctaagac      600

aaagcaagta attcaggggc tggaagcttt gaagaatgag cacaattcca ttttacaaag      660

tttgctggag acactgaagt gtttgaagaa agatgatgaa agtaatttgg tggaggagaa      720

atcaaacatg atccggaagt cactggagat gttggagctc ggcctgagtg aggcacaggt      780

tatgatggct ttgtcaaatc acctgaatgc tgtggagtcc gagaagcaga aactgcgtgc      840

gcaggttcgt cgtctgtgcc aggagaatca gtggctacgg gatgaactgg ccaacacgca      900

gcagaaactg cagaagagtg agcagtctgt ggctcaactg gaggaggaga agaagcatct      960

ggagtttatg aatcagctaa aaaaatatga tgacgacatt tccccatccg aggacaaaga     1020

cactgattct accaaagagc ctctggatga ccttttcccc aatgatgaag acgacccagg     1080

gcaaggaatc cagcagcagc acagcagtgc agccgcggct gcccagcagg gcggctacga     1140

gatccccgcg cggctgcgga cgctccacaa cctggtgatc cagtacgcct cgcaggggcg     1200

ctacgaggta gctgtgcccc tctgcaagca ggccctggag gacctggaga agacttcagg     1260

acacgaccac ccggacgtgg ccaccatgct caacatcctg gccttggtgt acagggatca     1320

gaataaatac aaagatgcag ctaacctact gaatgatgcc ttggctattc gtgagaaaac     1380

tttgggcaaa gatcatcctg cggtggcggc gactttgaat aaccttgcag tcctttatgg     1440

taaaagaggg aagtacaaag aagcagagcc gttgtgtaaa agagctctgg aaatccgaga     1500

aaaggttttg gggaaggatc accccgatgt tgccaagcag ttaaataact tggccttact     1560

gtgccagaac cagggcaagt atgaagaagt agaatattat tatcaaagag ccctcgagat     1620

ctaccagaca aaactgggac ctgatgaccc caacgtggct aagacgaaaa ataacctggc     1680

atcctgctat ttgaaacaag gaaagttcaa gcaagcagaa acactgtaca aagagattct     1740

cactcgtgca catgaaaggg agtttggttc tgtagatgat gaaaataaac ccatctggat     1800

gcatgctgaa gaaagagaag aatgcaaagg aaagcaaaag gatgggacat cttttggaga     1860

gtatggcggc tggtacaaag cctgcaaagt tgatagtcca actgttacaa ccactctaaa     1920

aaaccttggg gcactttaca gacgtcaagg caaatttgaa gctgcagaaa cgttagaaga     1980

agctgctatg aggtctcgta aacagggtct tgacaatgtt cacaaacaga gggtggcaga     2040

agtgctcaat gaccctgaga acatggagaa gcgcaggagc cgtgagagcc tcaacgtgga     2100

cgtggtcaag tacgagagtg gccctgacgg aggggaggaa gtgagtatga gcgtagagtg     2160

gaacgggatg aggaaaatga agctcgggct ggttaactga cttgctcagc gtcccatggc     2220

ctagccgccc gtgactctca cactgtctcc tgcatgacgg gtggcgcctc ccgcagcttc     2280

ccttctctct ccagtgctgc ccgctgtgtc tagcagcctc taggatcttg tcagagctgc     2340

acctctctgt gaactggcca ttcctttcgg tgctgctgtc ctttttgggg gggttcctga     2400

tttctgtata catgtagctt tgccagatat gtacttagta atataaactg tattaataaa     2460

atccatttac tgtgtaatac acgagtttaa aaattaagag cgatt                     2505


<210> 3730
<211> 577
<212> DNA
<213> Homo sapiens

<400> 3730
accgactgac tcagtgacct cggggtcgtt aggcctccac gtcctcgctg gagctgcgga       60

cctcagtcgt ccatccacac ctcccccctg ccgcccccgc ccatctcact ctcccaaccc      120

tgggcaccag ggcaggtcga cagcccgagg cactcctcta ctgcgtttcc aggcccagga      180

gacccactcc agcgccgcgg ttccttgcga cccggcagcc gttcagcaga cctcccattc      240

tttcctgcat catcgggcat tgtggaggca ccctacggtg attcctctca gagcctgttt      300

gtagaccggg caaggtcccc caggccagga tgtcaggcct ggtgttgggg cagcgggatg      360

agcctgcagg ccaccggctc agccaagagg agatcctggg gagcacacgg ctggtcagcc      420

aagggctaga ggccctacgc agtgaacacc aggccgtgct gcaaagcctg tcccagacca      480

ttgagtgtct gcagcaggga ggccatgagg aagggctggt gcatgagaag gcccggcagc      540

ttcgccgttc tatggaaaac attgagctcg ggctgag                               577


<210> 3731
<211> 542
<212> DNA
<213> Homo sapiens

<400> 3731
gttgtgagct gcggcagaga ctggtggctg gaggagacgc cggcgctgga gagtgcgctg       60

cgccgcccgc cgctgaggga ccgcggggtt agccactgct ggctgcttcc agtgttcgcc      120

gagaggtacc gggggtgaca gctccgggac cggccgaaag gcgaggaacc ggaagcccgg      180

gggagtgcga ccgcctcaaa tccagccttc ttgtttggtg ggacgaccgt cggttctgtc      240

cgggaggaat gacggggtca agccacataa agaagatccc taatagtcat ttctcaacaa      300

ttatatagtc aactgatgta acaatggtac taatattggg acgcagacta aacagagagg      360

atcttggggt gcgtgattcc ccagcaacta agcgaaaagt ttttgaaatg gaccccaaat      420

ctctgacagg tcatgagttt tttgacttct cttcaggatc atcccatgcc gaaaacatac      480

tccagatatt taatgaattt cgtgatagcc gcttattcac agatgttatc atttgtgtgg      540

aa                                                                     542


<210> 3732
<211> 2039
<212> DNA
<213> Homo sapiens

<400> 3732
atgaacttcc aggcgggcgg ggggcagagc ccgcagcagc agcagagcct ggcggctccg       60

gggggcggcg gcgctgccgc gcagcagctc gtctgcggcg ggcagttcgg cggcgcgggg      120

cccggggccg ggggcggcgg cggcccctcg cagcagctgg ccggcgggcc cccccagcag      180

ttcgcgctct ccaactccgc ggccatccgg gccgagatcc agcgcttcga gtccgtgcat      240

cccaatatct acgccatcta cgacctgatc gagcgcatcg aggatttggc gctgcagaac      300

cagatccggg agcacgtcat ctccatcgag gactcgtttg tgaacagcca ggagtggacg      360

ctgagccgct ccgtaccgga gcttaaagtg ggcatagtgg ggaacctgtc tagcgggaag      420

tcagccctgg tgcaccgcta tctgacgggg acctatgtcc aggaggagtc ccctgaaggg      480

gggcggttta agaaggagat tgtggtggat ggccagagtt acctgctgct gatccgagat      540

gaaggaggcc cccctgagct ccagtttgct gcctgggtgg atgcagtggt gtttgtgttc      600

agcctggagg atgaaatcag tttccagacg gtgtacaact acttcctgcg tctctgcagc      660

ttccgcaacg ccagcgaggt gcccatggtg cttgtgggca cgcaggatgc catcagcgct      720

gcgaatcccc gggttatcga cgacagcaga gcccgcaagc tctccacaga tctgaagcgg      780

tgcacctact atgagacgtg cgcgacctac gggctcaatg tggagcgtgt cttccaggac      840

gtggcccaga aggtagtggc cttgcgaaag aagcagcaac tggccatcgg gccctgcaag      900

tcactgccca actcgcccag ccactcggcc gtgtccgccg cctccatccc ggccgtgcac      960

atcaaccagg ccacgaatgg cggcggcagc gccttcagcg actactcgtc ctcagtcccc     1020

tccaccccca gcatcagcca gcgggagctg cgcatcgaga ccatcgctgc ctcctccacc     1080

cccacaccca tccgaaagca gtccaagcgg cgctccaaca tcttcacgat atgtgccact     1140

gtttccaact tttcatcaac aaaaaggcct ttccaactcc ttccaaatta gaagaccagt     1200

tggtgacaca cagcacctct ggacatgccc cctgtgcggg gccggaggcg ggccgggccc     1260

tgggactgct ctcagatgag aagcggccgc cgagctcccc actccagaga cccacgggaa     1320

cctttgtaac taaccccacc cccagggaag gctaggagcg ccggagcccg cgctgggggc     1380

tgccggggac caggcccggc cggacgctgc aggctcgctg catggagaag aaggcagctc     1440

ggccccacgc ccggcgctgg ccagcgcgac gaggcccaga ggggcggggg agtccaagcc     1500

cgcccggccc ggctgctcct ggggggcgct ttcctgcccc tcccctcctc tgctccttcc     1560

tgcatggacc tctgccgttc ctgctcctgc tccggaagcc gccgccgccg ccgcgcttgc     1620

cttgccccct ctttttggcc tccccctatt tcctaggatc cgcattcggg tggactctgc     1680

cccaggagct tgacagggtg cagggcctct tctggcctct ctcctctctc tgtccatcca     1740

ctgtgcccct tgggccacgc cgacgcgctc ggtgccacgt gccgtgtggt gtctgtgccg     1800

cagacgggcc atctgcccgc tcacttgtgg actttgcgct cccggttgtc gcgccctgtg     1860

ctcccgacca gcagccccac cgtccacctc ctcgcccccg cttctcttac gcccccgccc     1920

cgggcgtgct cctcgcgccc tcggcctctc tgtccttgct cttttgtaag gggcgggccc     1980

ggctcagtga cctgtgctgc tctgtatggt gccgtgtgta agaataaacc cgttggaat      2039


<210> 3733
<211> 1760
<212> DNA
<213> Homo sapiens

<400> 3733
ccgcagctgc cttcggcgcc gccagccccg ccatggctgc gccctgcgcg gaagagtgct       60

ggccctgggg aagccccttc ctcacccagg cttcacacat ttgaccctgg ctctctctca      120

ggaggacccc tcgctggaaa ggcattttaa gggccaccga gatgcagtta cctgtgtgga      180

cttcagtatc aacacaaagc agctggccag tggctccatg gactcatgcc tcatggtctg      240

gcacatgaag ccgcagtcac gcgcctaccg cttcactggc cacaaggatg ccgtcacctg      300

tgtgaacttc tctccttcgg gacacctgct tgcttccggc tcccgagaca agactgtccg      360

catctgggta cccaatgtca aaggtgagtc cactgtgttt cgtgcacaca cagccacagt      420

gaggagtgtc cacttctgca gtgatggcca gtccttcgtg acagcctctg acgacaagac      480

agtcaaagtg tgggcaactc atcgccagaa attcctgttc tccctgagcc agcatatcaa      540

ctgggtccgc tgtgccaagt tctcccccga cgggcggctc atcgtgtctg ccagtgatga      600

caagactgtt aagctgtggg acaagagcag ccgggaatgt gtccactcgt attgtgagca      660

tggcggcttt gtcacctatg tggacttcca ccccagtggg acgtgcattg ccgctgccgg      720

catggacaac acagtgaagg tgtgggacgt gcggactcac cggctgctgc agcattatca      780

gttgcacagt gcagcagtga acgggctctc tttccacccg tcgggaaact acctgatcac      840

agcctccagt gactcaaccc tgaagatcct ggacctgatg gagggccggc tgctctacac      900

actccacggg catcagggac cagccaccac tgttgccttt tcaagaacgg gggagtattt      960

tgcttctgga ggctctgatg aacaagtgat ggtttggaag agtaactttg atattgttga     1020

tcatggagaa gtcacgaaag tgccgaggcc cccagccaca ctggccagct ccatggggaa     1080

tctgccagaa gtggacttcc ctgtcccccc aggcagaggc aggagtgtgg agtctgtgca     1140

gagccagccc caggagcccg tgagtgtgcc ccagacactg actagcacgc tggagcacat     1200

tgtgggccag ctggatgtcc tcactcagac agtctccatt ctggagcagc ggttgacact     1260

gacagaagac aagctgaagc agtgtctgga gaaccagcag ctaatcatgc agagagcaac     1320

accatgatca ggggagcagg aatcaggagc tcggtggatt tgcaggtggc aggccaggga     1380

tttgtaccat gggacttggg taaataaagg ggactgaact ctgtgggaat cacatccata     1440

ctggagccct ggatttttgc agttctgccc tccaccttgc tatctgcacc aggaggctct     1500

ccacctggca gccagaggtc cccagtgggc cgggctcaca cacaaatgat gcttcagacc     1560

cgaatgagag gaccacattt tgcttaatgt aaaggagcca cttgaaaatg tctgctcctt     1620

cggggtcctg agattgtggc tccccctctg gaggaggtgg ctccacgatg ccttgatttt     1680

cactcatcat ttggacatgt gactggcttt tcctacctct gccatggtgt agaaattgat     1740

tgcacattga ttggatgagc                                                 1760


<210> 3734
<211> 1915
<212> DNA
<213> Homo sapiens

<400> 3734
atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac       60

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      120

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      180

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      240

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      300

ggccacagta gggaagaggc tggactatat cacagctgaa atatttctga ggacaatccc      360

agacccagga gatgttccag actcattttt ctgatattca gagagggcaa gagtcttggc      420

ctatgtcaca cagcagagtc caggactcca gaactccaac ctagcactct ggccagaaag      480

tcagccagag gaaggaaaac tgggaatgaa gagtcagagg tgagaagcta aagtcatgat      540

ctcaccaagg gatcaagagg tcgatattgg cggcttgtga cggtaaacac ggcaccatcc      600

tcctcctcat cccagacgga cacaggggcc tggaggagca aggaagggga agtcagacag      660

ttccacacca ccccccattg ccctcagcct tcaccccagg ccctgctcct ccctctgtac      720

ccctcacctg tggtggcagg gcatagtacc agcgagtgcg aggaagggtt gggggagctg      780

gtgaccccag gtctccccca ctggggccca gacagcccca ccccagccgc ctcagggccc      840

cggtggagtc gaaggggctg cagtggaggc gtggatggag tacaggaatt ctgatcctgg      900

agacccccaa agccccttct ccccagagct gaacccacac acgacagaga agcagggtac      960

aaagggcagg agagggaagc gagaggcagc aagccagagg cagcgactag gggtagctga     1020

aacctcagtc caggcactgc cgcatgcccc gcccctcccg gccaaggact ataccagccc     1080

agagaattag tctttttcag gacccctttc accctggtcc ctcgggtagc gcctccacta     1140

tctcagccct aagggacccc cgaaggtagc agctccaatc ccagtacagg aaggaaaagg     1200

ggaagtggga tgataggggg ttgggggcgg tagactcaga gagtcacgtg gccccagccc     1260

ctcccccgac cgatcccgaa aaaccagccc tgccagtcaa cctgccctca cctaggatct     1320

ggacctagga gtttagggcc tcggggcccc aaatccaaat tctggcccct cctgaggccc     1380

gaaatcctgc tcctggccac caccattaat ccctaatgaa aacagatgac cactctctac     1440

ccaccctagg atctttcctc caggtcccag aaccgtggct tcccggcctc tacccaggac     1500

cggggcgggg cgggggggcg gggggaaggg ggagagaggg aaggaggggt cacgaaatct     1560

gagggttccc tccccaatcc cagagtcaga ggagctggtt actgtggaaa caaacccctc     1620

cccgccaaac aaaaacaagg agggagacag ggaccaagac acgactgctc agagaggtag     1680

gcacactcag gcaggcagag gtggagggcc aaagacccgc agggacagga cagccagcca     1740

gaagttccag gcaggaacag ggcaggttcc tgcgggcagg tcctgagtca cactgacaga     1800

gaaccacgga gacgccagga ctccccgcag cagagaaacg ggccgacacc cagggaggcg     1860

cgagaataac tgaggcaagg aggaggagat gtagggaccc agagacaaga gaaaa          1915


<210> 3735
<211> 572
<212> DNA
<213> Homo sapiens

<400> 3735
cattagagaa gaagcaggca gcttgagaca ggtggagctg gatcaagctg tgaacgtgat       60

ttgctggaag ctggttgacg atgtgtcaca ctgtgtaagg gaatcgcatg gagatgggca      120

ttccgaactg ttaatgggga catgggactc cagttgtctc tgatcacttg tgtggatttt      180

cctggcgtag aacgacagaa gccgctagta agtcgccaag acctacagca ggaattctgc      240

accaaagggc ataaaatctt gttattttaa tttgcatctg ggagaatgtc tgagcaagga      300

gacctgaatc aggcaatagc agaggaagga gggactgagc aggagacggc cactccagag      360

aacggcattg ttaaatcaga aagtctggat gaagaggaga aactggaact gcagaggcgg      420

ctggaggctc agaatcaaga aagaagaaaa tccaagtcag gagcaggaaa aggtaaactg      480

actcgcagcc ttgctgtctg tgaggaatct tctgccagac caggaggtga aagtcttcag      540

gatcagactc tctgaaaact gcaaatggaa ag                                    572


<210> 3736
<211> 1654
<212> DNA
<213> Homo sapiens

<400> 3736
agtcggcggc cggactggga agatggacgc agctactctg acctacgaca ctctccggtt       60

tgctgagttt gaagattttc ctgagacctc agagcccgtt tggatactgg gtagaaaata      120

cagcattttc acagaaaagg acgagatctt gtctgatgtg gcatctagac tttggtttac      180

atacaggaaa aactttccag ccattgccat tcatcattgt tgtataccct ggagctggaa      240

ggagatgggg actggttctc agccttgcct ctcaccggcg gagaactgag gccggagggg      300

ggacaggccc cacctcggac acaggctggg gctgcatgct gcggtgtgga cagatgatct      360

ttgcccaagc cctggtgtgc cggcacctag gccgagattg gaggtggaca caaaggaaga      420

ggcagccaga cagctacttc agcgtcctca acgcattcat cgacaggaag gacagttact      480

actccattca ccagatagcg caaatgggag ttggcgaagg caagtccata ggccagtggt      540

acgggcccaa cactgtcgcc caggtcctga agaagcttgc tgtcttcgat acgtggagct      600

ccttggcggt ccacattgca atggacaaca ctgttgtgat ggaggaaatc agaaggttgt      660

gcaggaccag cgttccctgt gcaggcgcca ctgcgtttcc tgcagattcc gaccggcact      720

gcaacggatt ccctgccgga gctgaggtca ccaacaggcc gtcgccatgg agacccctgg      780

tacttctcat tcccctgcgc ctggggctca cggacatcaa cgaggcctac gtggagacgc      840

tgaagcactg cttcatgatg ccccagtccc tgggcgtcat cggagggaag cccaacagcg      900

cccactactt catcggctac gttggtgagg agctcatcta cctggacccc cacaccacgc      960

agccagccgt ggagcccact gatggctgct tcatcccgga cgagagcttc cactgccagc     1020

acccgccgtg ccgcatgagc atcgcggagc ttgacccgtc catcgctgtg gggtttttct     1080

gtaagactga agatgacttc aatgattggt gccagcaagt caaaaagctg tctctgcttg     1140

gaggtgccct gcccatgttt gagctggtgg agctgcagcc ttcacatctg gcctgccccg     1200

acgtcctgaa cctgtcccta gattcttctg atgtagagcg actggaaaga ttcttcgact     1260

cagaagatga agactttgaa atcctgtccc tttgaaaatc ctggggtcgg gggtggcacc     1320

tgtgagagcc tggggctcct ggtgccgctg cgtttcatcc atcccgcccg ctcgcctgcc     1380

gagggctgcg ccccgtgctg cctcccccca gagggccacc cgctgtgctc gtggactgag     1440

gctgcgctgc ccgggaggcc ttactgcttg gtgtcagact gcccagctca gagtgcccgt     1500

cagggcctgt gcatccgcac gcggagccgt ctgttaggag cttccagagt gttctctcga     1560

cactgccagc cccgtgttag cacctgggcc tcagtcccac ttgctcccag gcgccggttc     1620

tgtggttggt ttggaattaa agtcctgttt gaag                                 1654


<210> 3737
<211> 2238
<212> DNA
<213> Homo sapiens

<400> 3737
gacatagcaa gacctctgtt ccactgtgca ccactttatt tgcttccaca ctcaccttgt       60

agggaagagg cagaccctaa gagcttgatt tctaccttca agtgaattct ttacttcaga      120

aacaactcag gttgctggtt ggatttccct tctgaaatat ttaaaataat atttagaaaa      180

aataatgtca gagcacagca gaaattcaga tcaagaagaa cttctcgatg aggagattaa      240

tgaagatgaa atcttggcca acttgtctgc tgaagaactg aaagaactgc agtcggaaat      300

ggaagtcatg gcccctgacc ccagccttcc cgtgggaatg attcagaaag atcaaactga      360

caagccaccg acaggaaact tcaatcataa atctcttgtt gattatatgt attgggaaaa      420

ggcatccagg cgcatgctgg aagaggaacg agttcctgtc acctttgtga aatccgagga      480

aaagactcaa gaagagcatg aagaaataga aaaacgtaat aaaaatatgg cccagtattt      540

aaaagaaaag ctcaataatg aaatagttgc aaataaaaga gaatcaaagg gcagcagcaa      600

tatccaagaa acagatgaag aagatgaaga agaagaagat gatgatgatg acgacgaagg      660

agaagatgat ggtgaagaga gtgaagaaac gaacagagaa gaggaaggca aagcaaagga      720

acaaattaga aattgtgaga acaactgcca gcaggtaact gacaaagcat tcaaagaaca      780

gagagacaga ccagaggccc aagaacaaag tgagaaaaaa atatcgaaat tagatcctaa      840

gaagttagct ctagacacca gctttttgaa ggtaagtaca aggccttcag gaaaccagac      900

agacctggat gggagcttga ggagagttag gaaaaatgat cctgacatga aggaactcaa      960

cctgaacaac attgaaaaca tccccaaaga aatgttactg gactttgtca atgcaatgaa     1020

gaaaaacaag cacatcaaaa cattcagttt agccaatgtg ggtgcagatg agaatgtagc     1080

atttgccttg gctaacatgt tgcgtgaaaa tagaagcatc accactctca acatcgagtc     1140

caatttcatc acaggtaaag ggattgtggc catcatgagg tgtctccagt ttaatgagac     1200

gctaactgag cttcggtttc acaatcagag gcacatgttg ggtcaccatg ctgaaatgga     1260

aatagccagg cttttgaagg caaacaacac tctcctgaag atgggctacc attttgagct     1320

tccgggtccc agaatggtgg tcactaatct gctcaccagg aatcaggata aacaaaggca     1380

gaaacgacag gaagagcaaa aacagcagca actcaaggaa cagaagaagc tgatagccat     1440

gttagagaat gggttggggc tgccccctgg gatgtgggag ctgttgggag gacccaagcc     1500

agattccaga atgcaggaat tcttccagcc accgccacct cggcctccca acccccaaaa     1560

tgtccccttt agtcaacgca gtgaaatgat gaaaaagcca tcgcaggccc cgaagtacag     1620

gacagaccct gactccttcc gggtggtgaa gctgaagaga atccagcgca aatctcggat     1680

gccggaagcc agagaaccac ccgagaaaac caacctcaaa gatgtcatca aaacgctcaa     1740

gccagtgccg agaaacaggc cacccccatt ggtggaaatc actcccagag atcagctgct     1800

aaacgacatt cgtcacagca gtgtcgccta tcttaaacct gtgcaactgc caaaagaact     1860

ggcgtaagag gcaacagagc catctagaag aacaagaaat ggaaatagtg actcttggat     1920

tacagcatgg agactatgtc agcagcaata ctttaggatc cacgtggcag aactggaaac     1980

aatgctacca tctgataagg gtatttgtaa aaggcagaat gtttgggcca tgaagaagta     2040

ggggctgaag aggaaggtgg aaggagataa aatataatat ttagaggcaa tattttctac     2100

ttgcaatcaa tttgagtgac tcaggtgaaa tttagagtca tatttcccga agcagaagtt     2160

aaagaaaatt ttttaaacat ttgctttatt attgttttct tctggtaaat aataaatata     2220

acagaagtgt taactatt                                                   2238


<210> 3738
<211> 578
<212> DNA
<213> Homo sapiens

<400> 3738
aggatttgca ctttctcctt ttcttcagaa tgtgtatctg cctaagcagt gtgataactt       60

ttttcccaga ctggatcgat attccttagc tggtcctgtt gcagcaggag tccggtgact      120

ggagagagga agctcttggg cagcattttc cccaatacat ctctgctcat ctgactctta      180

tcttggcatc tgcttcctgg tggatctgaa ctgacccata agccacgctt actagtgatt      240

ttccagaaga tgaatccggc ctcggcgccc cctccgctcc cgccgcctgg gcagcaagtg      300

atccacgtca cgcaggacct agacacagac ctcgaagccc tcttcaactc tgtcatgaat      360

ccgaagccta gctcgtggcg gaagaagatc ctgccggagt ctttctttaa ggagcctgat      420

tcgggctcgc actcgcgcca gtccagcacc gactcgtcgg gcggccaccc ggggcctcga      480

ctggctgggg gtgcccagca tgtccgctcg cactcgtcgc ccgcgtccct gcagctgggc      540

accggcgcgg gtgctgcggg tagccccgcg cagcagca                              578


<210> 3739
<211> 660
<212> DNA
<213> Homo sapiens

<400> 3739
gggcgcgtcg aagatcttgt acctgtcgtt cgcagtggct cactttccca agccatgggc       60

agcaggaaga aggaaattgc cctgcaggtc aacatcagca cccaagagct ttgggaggaa      120

atgctcagtt ccaaaggact aactgttgtt gatgtctatc aaggctggtg tggcccctgc      180

aaacctgtgg tgagcctctt ccagaagatg aggatcgagg tcggcctgga ccttctgcac      240

tttgcattag cagaggcaga tcgtcttgat gtcctcgaaa agtacagagg gaagtgcgag      300

ccaacctttc tgttttatgc aggaggagaa ctggtggctg tggttagagg agcaaatgcc      360

ccactgctgc agaaaaccat cctagaccag ctggaggccg aaaagaaagt gctggctgaa      420

ggcagagaac ggaaagtgat taaagatgag gctctttctg atgaagatga atgtgtttcc      480

catggaaaga ataatggtga agatgaggac atggtttcat cagagaggac ctgtaccttg      540

gccatcatta aaccagatgc agtggcccat ggaaagactg atgagattat catgaagatt      600

caggaagctg ggtttgaaat tctaacaaat gaagagagaa ccatgacaga ggcagaagtg      660


<210> 3740
<211> 581
<212> DNA
<213> Homo sapiens

<400> 3740
ctctctgctc tcgcggccga ctcgcaagat ggcgccgcag aaagacagga agcccaagag       60

gtcaacctgg aggtttaatt tggaccttac tcatccagta gaagatggaa tttttgattc      120

tggaaatttt ggtaccttcc ctagtgaata tctagggttc tcttccctag ttttgcattt      180

tttctgtttt aaaataggag caatttctac gggagaaggt taaagtcaat ggcaaaactg      240

gaaatctcgg gaatgttgtt cacattgaac gcttcaagaa taaaatcaca gttgtttctg      300

agaaacagtt ctctaaaagg tatttgaaat accttaccaa gaaatacctt aagaagaaca      360

atcttcgtga ttggcttcga gtggttgcat ctgacaagga gacctacgaa cttcgttact      420

tccagattag tcaagatgaa gatgaatcag agtcggagga ctaggcaaag gctcccctta      480

cagggctttg cttattaata aaataaatga agtatacatg agaaatacca agaaattggc      540

ttttagttta tcagtgaata aaaaatatta tactcttgaa c                          581


<210> 3741
<211> 607
<212> DNA
<213> Homo sapiens

<400> 3741
acagccgaag ggagcgggcg agcggcgacg gcggcggcgg cgggcacaga ttaattaaaa       60

gaagaatgaa ctataatcct tgaagataac tgggcaattt tttaagtcgg aggctgttct      120

tactggtgtg aggatttaca cacgtcttca gtttttcagc acagaccagc agaccatcat      180

ttttagagga aatactccct ctgccctcct ttttggtttc cttggtgaag agtgtaccat      240

ggaaaacctc cagacaaatt tctccttggt tcagggctca actaaaaaac tgaatgggat      300

gggagatgat ggcagccccc cagcgaaaaa aatgataacg gacattcatg caaatggaaa      360

aacgataaac aaggtgccaa cagttaagaa ggaacacttg gatgactatg gagaagcacc      420

agtggaaact gatggagagc atgttaagcg aacctgtact tctgttcctg aaactttgca      480

tttaaatccc agtttgaaac acacattggc acaattccat ttaagtagtc agagctcgct      540

gggtggacca gcagcatttt ctgctcggca ttcccaagaa agcatgtcgc ctactgtatt      600

tctgcct                                                                607


<210> 3742
<211> 580
<212> DNA
<213> Homo sapiens

<400> 3742
agttggctgg gtccgggctt ggggactgca acgcgggtaa gggactcagc ctgggcttgc       60

cagctgtggg gatgaggcga agcatccatc ctcttggcag ttaagtggct ggtcctgatc      120

tgagggatct gcaaatttgg ctcatggaaa gaggtggctg aattctgcgt ctcccattaa      180

acggatactg gcgttgttga tacgggtttc gcatggaccc tgtcctgtgc cagggttttt      240

aatctagcta ttaaaggaac tggagaataa caagtaaggg ttgcaaggtc gctgacaggc      300

gtgggaaact tgtgaaggat tagaatgcta agtggctttc agcttttttc acactaagtc      360

ttctgtgctt caccatctac ataatgaatc ccagtatgaa gcagaaacaa gaagaaatca      420

aagagaatat aaagaatagt tctgtcccaa gaagaactct gaagatgatt cagccttctg      480

catctggatc tcttgttgga agagaaaatg agctgtccgc aggcttgtcc aaaaggaaac      540

atcggaatga ccacttaaca tctacaactt ccagccctgg                            580


<210> 3743
<211> 2126
<212> DNA
<213> Homo sapiens

<400> 3743
atggtactaa tattgggacg cagactaaac agagaggatc ttggggtgcg tgattcccca       60

gcaactaagc gaaaagtttt tgaaatggac cccaaatctc tgacaggtca tgagtttttt      120

gacttctctt caggatcatc ccatgccgaa aacatactcc agatatttaa tgaatttcgt      180

gatagccgct tattcacaga tgttatcatt tgtgtggaag gaaaagaatt tccttgccat      240

agagctgtgc tctcagcctg tagcagctac ttcagagcta tgttttgtaa tgaccacagg      300

gaaagccgag aaatgttggt tgagatcaat ggtattttag ctgaagctat ggaatgtttt      360

ttgcagtatg tttatactgg aaaggtgaag atcactacag agaatgtaca gtatctcttt      420

gagacatcaa gcctctttca gattagtgtt ctccgtgatg catgtgccaa gttcttggag      480

gagcaacttg atccttgtaa ttgcttagga atccagcgct ttgctgatac ccattcactc      540

aaaacactct tcacaaaatg caaaaatttt gcgttacaga cttttgagga tgtatcccag      600

cacgaagaat ttcttgagct tgacaaagat gaacttattg attatatttg tagtgatgaa      660

cttgttattg gtaaagagga gatggttttt gaagccgtca tgcgttgggt ctatcgtgcc      720

gttgatctga gaagaccact gttacacgag ctcctgacac atgtgagact ccctctgttg      780

catcccaact actttgttca aacagttgaa gtggaccaat tgatccagaa ttctcctgag      840

tgttatcagt tgttgcatga agcaagacgg taccacatac ttgggaatga aatgatgtcc      900

ccaaggacta ggccacgcag gtccactggc tattctgagg tgatagttgt cgttggagga      960

tgtgagcgag ttggaggatt taatcttcca tacactgagt gctacgatcc tgtaacagga     1020

gaatggaagt ctttggctaa gcttccagaa tttaccaaat cagagtatgc agtctgtgct     1080

ctaaggaatg acattcttgt ttcaggtgga agaatcaaca gccgtgatgt ctggatttat     1140

aactcacagt taaatatttg gatcagagtt gcctctctca ataaaggcag atggcgtcac     1200

aaaatggctg tcctccttgg taaagtatat gttgtcggtg gctatgatgg gcaaaacaga     1260

cttagcagcg tagaatgtta tgattccttt tcaaatcgat ggactgaagt tgctcccctt     1320

aaggaagccg tgagttctcc tgcagtgact agctgtgtag gcaaactgtt tgtgattggt     1380

ggaggacctg atgataatac ttgttctgat aaggttcaat cttatgatcc agaaaccaat     1440

tcttggctac ttcgtgcagc tatcccaatt gccaaaaggt gtataacagc tgtatcccta     1500

aacaacctga tctatgttgc cggtggactg accaaggcaa tatactgtta cgatccagtt     1560

gaagattact ggatgcacgt acagaataca ttcagccgtc aggtaataac ataaagcagt     1620

acaaaagaaa aataaatcta agagggacca agtacataat cattattaat acactggaat     1680

ttcaatttta aaatatttca ggctgggcgt ggtggctcac gcctgtaatc ccagcacttt     1740

gggaggccga ggtggataga tcacttgagg tcaggagttc aagaccagcc tggctaatat     1800

ggtgaaaccc cgtctctact aaaaaattat ggccaggcgt ggtggttcat gcctgtaatc     1860

ccagcacttt gggaggctga ggcaggccaa tcacctgagg tcgggagttc gagaccagcc     1920

tgaccaacat ggagaaaccc cgtctctgct aaaaatacaa aattagctgg gcgtggtggc     1980

gcattgcctg taatcccagc tactagggag gctgcggcag gagaattgct tgaacccggg     2040

aggtggaggt cgcggtgagc cgagatcgag ccattgcact ccagcctgga cagcaagagc     2100

gaaactccgt ctcaaaaata aataaa                                          2126


<210> 3744
<211> 1780
<212> DNA
<213> Homo sapiens

<400> 3744
ctctttgagg ctttctgatg cctagagtga gctcaactca aaggtttcca gcctcacact       60

cgcctcacat tcccccacag tcacattgcg ctctgtgatt ctgaggaata cagtgtgcca      120

gcatccgatc cagtctcctt tcacctgcag gtgttccaga aacttcaaaa tgcgtctgga      180

agaactgaaa agattgcaga atcctctaga acaagttaat gatggaaaat attcatttga      240

aaacattcag cgagcatggc gagagtacct gcagcggcag gagcccctgg ggaagaggag      300

cccgtcccca ccctctgtct cctcagagaa gctgagcagc tctgtcagca tgaacacctt      360

ctccgacagc agcacacccg attaccgaga ggatgggatg gatctaggca gtgacgccgg      420

cagcagcagc agcagcagcc gcgccagttc acagtccaac tccaccaaag tgaccccttg      480

ctccgagtgc aaatcttcat cgtcgccggg gggcagcctg gacttggtgt ctgccctgga      540

ggactatgag gagcccttcc cggtctacca gaagaaggtg attgatgagt gggcgccgga      600

ggaggacggg gaggaggagg aagaggagga cgagcgcgac cagcgagggt accgggatga      660

ccgctctccg gcccgggaac cgggggacgt aagcgccagg acccgcagcg gcggcggcgg      720

gggcaggagc gccaccaccg ccatgccgcc cccggtgccc aacggcaacc tccaccagca      780

cgacccccag gacctcaggc acaatggcaa cgtggtggtg gctggccggc cgagctgttc      840

ccggggcccc cgccgggcga tccaaaagcc ccagccggct gggggccggc gcagtggccg      900

cggcccggcg gctggggggc tctgccttca gcccccagac ggcgggacgt gcgtccccga      960

agagcccccg gtgccaccta tggattggga ggcgctggag aagcatctgg ccgggctgca     1020

gttccgggag caggaggtac ggaaccaggg ccaggcgagg accaactcca cctccgcaca     1080

gaaaaatgag agagagtcta tcagacagaa gttggcactt ggaagcttct ttgatgatgg     1140

cccaggaatt tataccagct gtagcaaaag tgggaagcca agcctttcct cccgactgca     1200

gagtgggatg aacttgcaga tatgctttgt caacgacagt ggcagtgata aggacagtga     1260

tgctgatgac agtaagactg aaaccagctt ggacaccccc ttgtctccca tgagcaaaca     1320

gagttcttcc tattctgata gagacactac tgaagaggag tctgaatcct tggatgacat     1380

ggacttcctt acaaggcaaa agaaattgca agctgaagcc aaaatggccc ttgccatggc     1440

caaaccaatg gccaaaatgc aagtagaagt ggagaaacag aacaggaaaa agtctcccgt     1500

cgctgatctt ctgccacaca tgcctcatat aagtgaatgc ttgatgaaaa gaagtttaaa     1560

acccaccgac ctgagagaca tgactattgg gcagctacaa gtgatagtca atgatctcca     1620

ttcccagata gaaagcttga atgaagagtt ggtccagctg cttctcatcc gagatgagct     1680

gcacacagag caggatgcca tgctggtgga cattgaagac ttgaccagac atgctgaaag     1740

tcagcagaag cacatggcag agaaaatgcc tgcaaagtga                           1780


<210> 3745
<211> 2096
<212> DNA
<213> Homo sapiens

<400> 3745
cttctgagtg ggggcgggga ctgctggagt tgcggggcct gcctggggta gggcggggca       60

ggacagcttg gagatagggc ccggaattgc gggcgtcact ctgctcctgc gacctagcca      120

ggcgtgaggg agtgacagca gcgcattcgc gggacgagag cgatgagtga gaacgccgca      180

ccaggtctga tctcagagct gaagctggct gtgccctggg gccacatcgc agccaaagcc      240

tggggctccc tgcagggccc tccagttctc tgcctgcacg gctggctgga caatgccagc      300

tccttcgaca gactcatccc tcttctcccg caagactttt attacgttgc catggatttc      360

ggaggtcatg ggctctcgtc ccattacagc ccaggtgtcc catattacct ccagactttt      420

gtgagtgaga tccgaagagt tgtggcagcc ttgaaatgga atcgattctc cattctgggc      480

cacagcttcg gtggcgtcgt gggcggaatg tttttctgta ccttccccga gatggtggat      540

aaacttatct tgctggacac gccgctcttt ctcctggaat cagatgaaat ggagaacttg      600

ctgacctaca agcggagagc catagagcac gtgctgcagg tagaggcctc ccaggagccc      660

tcgcacgtgt tcagcctgaa gcagctgctg cagaggttac tgaagagcaa tagccacttg      720

agtgaggagt gcggggagct tctcctgcaa agaggaacca cgaaggtggc cacaggcaga      780

gaacagcatt gacttcatca gcagggagct gtgtgcgcat tccatcagga agctgcaggc      840

ccatgtcctg ttgatcaagt aagtctggac ccatcccctt cagccacccg ccaaggagac      900

atgggcgcca ggaatctccg ggagggggcc ctggcatgag gctccaagtt ctctgcgtgt      960

cgaccacatc gctaaggctc aagatctttt ttgggaagcc cccctggcag cagggtcatg     1020

gaaggaggaa ggtcagagga ggggagggct cgggcagcag gggatgggcc ggggctgtcc     1080

catgcctttc cacaggtgtc agcggggggc atgcccaggt aaggctccat aaccagtgag     1140

cccagtctcg gctgactgca acctctgtct cctggattca aacgattctc ctgcctcagc     1200

ctcccgagta gctgggacta caggcgcccg ccaccaggcc tggcttattt ttgtattttt     1260

agtagagacg aggtttcgcc atgttggcca ggctgctctc catctcctga cctcatgatc     1320

cgcccgcctc ggcctcccag tgttgggatt acaggcgtga gccaccgtgc gtggcccacc     1380

atagacgatt tttaagccat aaaaagaaac gaagcactga cacgggctcc agcatggatg     1440

agcctttaaa acatcgcgct aagtggacga attcagacac aaccgtctac gtgttgtatg     1500

gctgcattca cgttcaagtc aagtccaaat agggcacact gcagagacaa agccagagca     1560

gtccacggat attttgattc aagacagaat tactctgaga aggagtccct gtcgttcatg     1620

atagacacga tgaaatccac cctcaaagag cagttccagt ttgtggaagt cccaggcaat     1680

cactgtgtcc acatgagcga accccagcac gtggccagta tcatcagctc cttcttacag     1740

tgcacacaca tgctcccagc ccagctgtag ctctgggcct ggaactatga agacctagtg     1800

ctcccagact caacactggg actctgagtt cctgagcccc acaacaaggc cagggatggt     1860

ggggacaggc ctcactagtc ttgaggccca gcctaggatg gtagtcaggg gaaggagcga     1920

gattccaact tcaacatctg tgacctcaag ggggagacag agtctgggtt ccagggctgc     1980

tttctcctgg ctaataataa atatccagcc agctggagga aggaagggca ggctgggccc     2040

acctagcctt tccctgctgc ccaactggat ggaaaataaa aggttcttgt attctc         2096


<210> 3746
<211> 439
<212> DNA
<213> Homo sapiens

<400> 3746
agctttggga gcttgggcta ccctgtaacg tctaaatgcc tgtgcactgt gggattgatg       60

acctcccaca actggagcag ccgggaacag ctctgaccac agtggttccg gggagaagcc      120

tttccaggac ccatgtgtag gcacaactgt tttccctgat caggatactt gcggcactca      180

acagaggaaa gaaattccta agggaacact gctcagaaag tactgcagca tgtcttcaaa      240

tgcctgagga tcaagttgga aaactagaag caacagaaaa cacaataagc gcaatggcgg      300

cggccgcggc ggagcagcaa cagttctacc tgctcctggg aaacctgctc agccccgaca      360

atgtggtccg gaaacaggca gaggaaacct atgagaatat cccaggccag tcaaagatca      420

cattcctctt acaagccat                                                   439


<210> 3747
<211> 3761
<212> DNA
<213> Homo sapiens

<400> 3747
attgtaactc ttcctgtaga acctgttcat gtccagggtg agtaaactag ggtagaaatg       60

tcttcctaaa acagcctccg gtgaaattcg tccttggatt caaagcaact tacttcctag      120

gaagtatcag gcaaatccca actgccctcc attttagaaa ggtctctttt ctgggaaaat      180

ctgccactga gaactttgcc ctcctctccc tgatgggagg aaggagtaga attagggagg      240

tgtcactcag gagagttgct gatgtcagta gtgtgtcagc cgtgggaggc tcagtttgtg      300

aaattgagtt acacctaagt gtcttatgaa actcagttca gaactcaccg gagctgccgt      360

ctgggagggg ggagggcgga agaaccctga ggtttttcct cacatttctg tcccattttt      420

ggaacctctg gatttaaaga aatgaaaacc tcaagtttgt ggagatttta agaaatggtt      480

attccaatgg aaacagctgg agaacttata tttccgtgag aaaaaatttg ctgttgaagt      540

tcatgatcca cgaaggattt cagtttcaag aagaaccttt gggcaaagtg gcttgtttgt      600

gcaaacatgg tatgctaact cttctctcat caagtccatt tgggtaatgg caattagtca      660

gcatcagttt tacttggacc ggaagcaaag caaagcaaaa attccttcag ccaggagttt      720

agatgagatt gcaatggatt tgacagagac aggaacacaa agggcctcca agctggtgac      780

actggagacg aaaagtcagt tcatcatggc aagtaatggc agtttaatct cctcaggttc      840

tcaagactca gaagttagtg aagagcaaaa gagagaaaaa atccttgaac taaagaagaa      900

ggagaaacta ttacaagaaa aacttctgaa aaaagttgag gagcttaaga agatctgtct      960

gcgggaggct gagctcacag gcaaaatgcc aaaggagtat cccctgaaca taggcgagaa     1020

gcctcctcag gtcagaagac gtgtgggtac tgcgttcaaa ttagatgaca acttgctgcc     1080

gagtgaagaa gatcctgctt tgcaagaact ggagagtaat tttctaatac aacaaaagct     1140

ggtggaagct gcaaagaaac ttgccaatga gccagacctt tgtaaaactg tgaagaaaaa     1200

gcgaaagcaa gattacacag atgcgatgaa aaagcttcag gagattgaaa atgcaataaa     1260

cgaataccga attaggtgtg gaaagaaacc cagccagaaa gcaacagtgt taccagaaga     1320

cataatcccc tcagagagta gctctttgtc tgacaccacc acctatgatg atcccagtga     1380

tgccttcact tttcctgggc agcgatcaag ttcagtacct cattctccaa gaattcttcc     1440

ccccaagtct cttggtattg agcgaatcca tttcagaaag tcgtccatca atgaacagtt     1500

tgtggatacc aggcagtcca gagaaatgct gtccacacac agcagccctt acaaaactct     1560

ggagaggcgg ccccagggag gacgaagcat gcccaccacg ccagttctta cccgaaacgc     1620

ctacagcagc agccacttgg aacccgaatc ttcatctcag cactgccgcc agcggagtgg     1680

aagcctggag tcccagtccc acctgctctc cgagatggac agcgataagc catttttctc     1740

cctctccaaa tcccaaagaa gcagcagcac agaaatcctc gatgacgggt cttcttatac     1800

aagccaatca agcacagagt attactgtgt gacaccagtt accggcccct attacaccac     1860

ccagaccctg gacactcgca ccaggggtcg gaggaggtca aagaaacaga atgtttctac     1920

ttcaaattca ggaagcatgc ccaacctagc acaaaaggat agtttgagga atggtgttta     1980

ctcaaagagt caggagccac cgtcttccag ttactacatt gccgggtaca caccctatgc     2040

agagtgtgac ttttattaca gtggtggtta tgtctatgag aatgacaccg agggacagta     2100

tagtgtcaac ccttcctacc ggtcctcagc ccactatgga tatgagcgcc agagggacta     2160

cagcagatcc tttcacgaag atgaggtcga ccgggtaccc cataacccat atgcaactct     2220

ccggctgcca aggaaggctg ctgcaaaatc ggagcacatc accaaaaaca tccacaaggc     2280

cttagttgcc gagcacttgc gtggctggta ccagcgggcc tctgggcaga aggatcaggg     2340

acacagcccg cagaccagct ttgactcaga caggggatca cagagatgcc tggggtttgc     2400

ggggctgcaa gtaccttgtt ctccaagcag tcgtgcatcc tcgtactctt cagtgtcttc     2460

tacaaatgct tctgggaact ggaggaccca gttaaccata gggctgtcgg attacgagac     2520

tccagcacat tcttcttaca ccagctgcta tggcaatgtc tataatcctt taccctctcc     2580

aagcagacaa tacacagaaa tcagtcaact ggatggtaca gatggaaacc agctggaaga     2640

caacctggag agtagtgagc agagactctt ttggcatgaa gattcaaagc ctggaacatt     2700

agtctgaact gcagttggac ctcctgacca agcactgcgt tctcacacta gtgtgccttg     2760

caaattgtat ttgtcttccg agaggatgtt cgttttagaa acctaaagac atcaaaggtt     2820

gaagagaaga cttagttgcc ctggaagtga atcagtgaat cacacaccaa gccccacaaa     2880

gcccctaaag gaggatttgg cctttcaaac tctaggcact aacgtaactg tagggtctgc     2940

ccacatgttg aagtattgcc aagagaggac tcagtgtgaa gccttcatca atagcaagca     3000

ctttttaagg gagtaaaagt tgttaaaggc aaacctcaaa aacatgaaag ggcattcagg     3060

atgtcccatg gcaataagaa caggggaaat ctcagagcac aattcagcag gatgagagaa     3120

ggggaaccag aagctccgga gtcattgctc acttcagagt ttgaattcgt gagctgacaa     3180

agagtaacat gctctttcta cacagacatg gacaatttag acagtattgg aaaattactt     3240

gaagctggat tttcatgaag ttctgaatga gtgtaaatgt tttttaggat actataaaga     3300

gtgatgtttt tcataagcac cataaaatgg gttctggaaa aactgattac cttagcatcc     3360

tgtaatataa cttatggtag cagattgggg aaaatgaagc agcccactga ataattgaca     3420

aagtctgctt ggagaacatt ctaaggtaca atatcatgga gctccttttt cctttctcca     3480

ctaattgcgt gatgagctat tgttctggct gttaattctc caactcggct gtcatttgaa     3540

gtggcagact taatatggaa agtttttata attatgagtt tgaaaaagca ttttaagatg     3600

atacagaaag tatccaaaac aacagaaaaa aaaagccacg tcattttaga tgaattgcgt     3660

gccttaaaat ggtgaacgtt agaaaattaa acaagtctgg attccacaag tagttccaag     3720

tcaccaagtg acaaaaacaa ggttaacatt aaaaaagaaa a                         3761


<210> 3748
<211> 648
<212> DNA
<213> Homo sapiens

<400> 3748
accgggagtg tggctggttt ctgttgcctg ttttgatact cttctcctgg tgggtgtgta       60

cactggcact gagctgcagt aggatttttc cttggatagt ctggtctgga gctgggacag      120

cagctgctgc tgtggaaagg ccagctggca agatgatgga agaaatctcc attatggtag      180

cctatgacgc ccatgttttc agccagctgc acgatgaaga cttcctcact agtctggtgg      240

ccatcagcaa gcccaggtct atggtaccaa ccaagaagct gaagaaatat gagaaagaat      300

atcagacaat gcgagagagt cagctgcaac aggaagaccc aatggataga tacaagtttg      360

tatatttgta ggtaactcca gctgttgcat ttatactggg aatcttcata agaagctgag      420

agaaagagag gggaaaaaga aagtggcttt ctactttcaa aaatgaaaca aaaaggaaaa      480

atggcaaagt actgttttag ctgtgcatgt catatccaca aagactttta gcaggtgaac      540

tgttccaaga ctgacacaag gatgtttcaa acttgcctct gtctgtagaa aatgttaaaa      600

ataccaactc acttggaagg aaaaataaaa atcacaaagg tatattga                   648


<210> 3749
<211> 2076
<212> DNA
<213> Homo sapiens

<400> 3749
aggtattgct ccggagggtg ttactcgtta gcgtcagttt ttcattaaag ggcagtattt       60

aaagtcagtt ggcaagcagt ggaataagat ttttgtaaag aaaccttgtg cagcatggat      120

tctctaccag atgaattttt tgtgaggcat cctgctgtgg aggatcagag gaaggaagaa      180

actgagaata agctagaaaa atcatctggt caactgaaca aacaggaaaa tgacatacct      240

actgatcttg tccctgttaa cctactatta gaagtgaaga agttattaaa tgcaattaat      300

actctaccaa aaggtgtggt tcctcacatt aagaagttct tacaagaaga tttttccttc      360

caaactatgc agagagaagt tgcagctaac agccagaatg gtgaggaaat tgttcctgct      420

ttgactttac gtttcttgat tacacagcta gaagcagcac ttaggaacat tcaagctggc      480

aattataccg cacaccagat taatattggt tattatttga cattactgtt tttatatgga      540

gtagcactca ctgaaagagg aaagaaagag gattatacag aagctgagaa taaatttctg      600

gtgatgaaga tgatgatcca agaaaatgaa atttgtgaaa actttatgtc tttagtttat      660

tttggacgtg gtttactgcg atgtgctcaa aagagatata atggaggact gctagaattt      720

cataaaagct tacaagaaat tggagacaaa aatgaccatt ggtttgacat agatcctaca      780

gaagatgaag atttacctac aacttttaaa gatcttctta ataattttat caagacaact      840

gaaagcaata taatgaagca gacgatttgt agttacctag attgtgaacg atcttgtgaa      900

gctgacattt tgaagaacac cagttataag ggattttttc agttaatgtg cagtaaaagt      960

tgctgtgttt atttccataa aatttgctgg aaaaagttca agaatttaaa gtatccaggt     1020

gaaaatgatc agagttttag tgggaaaaaa tgtttgaagg aaggatgtac aggtgacatg     1080

gtaaggatgc tgcaatgtga tgtacctgga attgttaaaa ttttgtttga agttgtgaga     1140

aaggatgaat atatcaccat tgaaaattta ggagcaagtt atagaaagtt gatatctctg     1200

aaaataactg atactgatat aagaccgaag atcagtttaa aatttaatac aaaagatgaa     1260

atgcctatct tcaagcttga ttataattat ttctatcatc tgcttcatat aattattatt     1320

tctggtactg acattgttcg acaaatattt gatgaggcta tgccacctcc tcttttgaaa     1380

aaagagcttc ttatacacaa gaatgtgctg gaatcctact acaaccatct ttggaccaat     1440

catcctttgg gtggatcatg gcatctgctt tatcctccta acaaggagtt accgcaatcc     1500

aaacagtttg acttatgcct cctgttagct cttataaaac atttaaatgt gttccctgca     1560

cccaaaaaag gatggaatat ggaaccgcca tcttctgaca tctctaaatc tgcagacatc     1620

ctgagactgt gcaaatacag ggatatcctc cttagtgaga ttttgatgaa tggtctcact     1680

gagtcacagt tcaattcaat ttggaaaaaa gtttcagata ttcttctgcg ccttgggatg     1740

atgcaagagg atattgacaa agtgaaggag aatcccattg agaatatctc ccttgattac     1800

catcagctat ctgtctacct aggcatacca gtaccagaaa tcatacagag gatgttatcc     1860

tgctatcaac aaggaattgc tctacagtca ataacaggca gtcagcgtat tgaaatagaa     1920

gagttacaga atgaggaaga agaactaagt ccacctctca tggagtacaa tataaatgtg     1980

aaatcacacc ctgagataca gtttgcagaa attaataaag atgggacctc aatacccagt     2040

gaatcttcaa cagaatctct taaagatctc caggaa                               2076


<210> 3750
<211> 697
<212> DNA
<213> Homo sapiens

<400> 3750
ttatctgtct cctcgtttcc ttttccctct attctttctc ccaccatctc gccctctcac       60

cctgtaaccc tcttacccac ttcctccgac tttaaataaa aggctgatct gaccttcttt      120

ttgcagaaga tgaatccggc ctcggcgccc cctccgctcc cgccgcctgg gcagcaagtg      180

atccacgtca cgcaggacct agacacagac ctcgaagccc tcttcaactc tgtcatgaat      240

ccgaagccta gctcgtggcg gaagaagatc ctgccggagt ctttctttaa ggagcctgat      300

tcgggctcgc actcgcgcca gtccagcacc gactcgtcgg gcggccaccc ggggcctcga      360

ctggctgggg gtgcccagca tgtccgctcg cactcgtcgc ccgcgtccct gcagctgggc      420

accggcgcgg gtgctgcggg tagccccgcg cagcagcacg cgcacctccg ccagcagtcc      480

tacgacgtga ccgacgagct gccactgccc ccgggctggg agatgacctt cacggccact      540

ggccagaggt acttcctcaa tcacatagaa aaaatcacca catggcaaga ccctaggaag      600

gcgatgaatc agcctctgaa tcatatgaac ctccaccctg ccgtcagttc cacaccagtg      660

cctcagaggt ccatggcagt atcccagcca aatctcg                               697


<210> 3751
<211> 1185
<212> DNA
<213> Homo sapiens

<400> 3751
tctgccgggt tccgggaaaa ggagctcctg ctgccactgc tcttccggag cctgcagcat       60

ggggcccctg ccgcgcaccg tggagctctt ctatgacgtg ctgtccccct actcctggct      120

gggcttcgag atcctgtgcc ggtatcagaa tatctggaac atcaacctgc agttgcggcc      180

cagcctcata acagggatca tgaaagacag tggaaacaag cctccaggtc tgcttccccg      240

caaaggacta tacatggcaa atgacttaaa gctcctgaga caccatctcc agattcccat      300

ccacttcccc aaggatttct tgtctgtgat gcttgaaaaa ggaagtttgt ctgccatgcg      360

tttcctcacc gccgtgaact tggagcatcc agagatgctg gagaaagcgt cccgggagct      420

gtggatgcgc gtctggtcaa gggtgagtgt ggggctctgg gaatcctctg ggaggacctt      480

ggatgacttt ctgaccttcc ccaggcacgt tttcagggtc atgatcctgc ccccgcccgg      540

gggatctact gtcctcccag tcacacccct ctccccgcac cgccttcctg ctgtcttctc      600

ttcttcccag aatgaagaca tcaccgagcc gcagagcatc ctggcggctg cagagaaggc      660

tggtatgtct gcagaacaag cccagggact tctggaaaag atcgcaacgc caaaggtgaa      720

gaaccagctc aaggagacca ctgaggcagc ctgcagatac ggagcctttg ggctgcccat      780

caccgtggcc catgtggatg gccaaaccca catgttattt ggctctgacc ggatggagct      840

gctggcgcac ctgctgggag agaagtggat gggccctata cctccagccg tgaatgccag      900

actttaagat tgcccggagg aagcaaactc ttcgtataaa aaaagcaggc catctgctta      960

acccttggct ccaccataag gcactgggac tcggatttct ctatctgata gaggtatttt     1020

ctgtggccct gggagctgtc tgtctttccc ctacccccaa ggatgccagg aagacgtcca     1080

ccattagcca tgtggcaacc tttacttcta tgcctcacaa gtgcctttca gagagcccca     1140

attctgcttt cccacaaaat aaacctaatg ccatcaggca aaaca                     1185


<210> 3752
<211> 1505
<212> DNA
<213> Homo sapiens

<400> 3752
attactacag ggcaggaagg gcacgttctc atcagcatgg atcagctgga aaatgcaaaa       60

atggagcaca caaatgcatc tttcgatacc ttcttctgtg agacaagagc tgggaagcat      120

gtgcctagag cactcttcgt ggacttggag ccaactgtta tagatgggat ccggacgggc      180

cagcaccgtt cactcttcca ccccgagcag ctccttagcg gaaaggagga tgctgctaac      240

aattacgcgc gaggccgtta ctctgtgggg tcggaggtca tcgaccttgt gctggagagg      300

acccggaagc tggcagaaca gtgtggtgga cttcagggat ttttgatttt ccgaagcttt      360

ggaggaggca ctggttcagg gtttacgtct ctcttaatgg agaggctcac aggagaatat      420

agcagaaaga ctaagctgga gttctcggtc tacccagccc ccaggatctc cactgctgtg      480

gtagagcctt ataactctgt cctcaccacc cactccacca cagagcacac ggactgtacc      540

ttcatggtgg acaacgaggc cgtctatgat atatgccatc gtaaactcgg tgttgaatgc      600

ccctctcatg ccagcatcaa tagattggtg gttcaggtgg tatcttccat cactgcctcc      660

ctccggtttg aagggccctt gaatgtagac ctaattgaat tccagaccaa cctggtacct      720

tatccgagaa tacatttccc catgacagcc ttcgccccca tcgtctctgc tgacaaagcc      780

taccatgagc agttctctgt gtcagacatc accactgcct gctttgagtc ctccaaccag      840

ctggtcaagt gtgatcctcg gcttgggaag tacatggcct gctgcctact ctatagaggg      900

gatgtggtcc ccaaggaagt gaatgcagca atcgcagcca cgaagtcgag gcactctgtt      960

cagtttgtag attggtgtcc aactggtttc aaggtgggca tcaacaatcg gccgcccacg     1020

gtgatgccgg gtggggacct ggccaaagtc caccggtcca tctgcatgct gagcaacacc     1080

acggcgattg tggaggcctg ggcccgcctg gaccacaagt ttgacctcat gtacgccaag     1140

agagcatttc tgcactggta cctcagagaa ggcatggaag aagcagagtt cttggaggcc     1200

agggaagatc tggcagccct ggagagggac tatgaggaag tggcgcaaag tttctgaggc     1260

atgtatgatg ggtgcaaatg aatgtcaagt taaaatggca tgttttcttt tcaagccgtt     1320

atatgcctag tgggtagttc ccctgatgag cagaaaaatg aactcaaatc aggcaagact     1380

ctaggttcca cactaaatta agtgggtcag taccaacaat gaacacatta tttcctggtc     1440

tactggtaca agtcagctct gctacctggg agcctttgga agcttagagt cctttgaact     1500

gctga                                                                 1505


<210> 3753
<211> 2602
<212> DNA
<213> Homo sapiens

<400> 3753
accgactgac tcagtgacct cggggtcgtt aggcctccac gtcctcgctg gagctgcgga       60

cctcagtcgt ccatccacac ctcccccctg ccgcccccgc ccatctcact ctcccaaccc      120

tgggcaccag ggcaggtcga cagcccgagg cactcctcta ctgcgtttcc aggcccagga      180

gacccactcc agcgccgcgg ttccttgcga cccggcagcc gttcagcaga cctcccattc      240

tttcctgcat catcgggcat tgtggaggca ccctacggtg attcctctca gagcctgttt      300

accgggcaag gtcccccagg ccaggatgtc aggcctggtg ttggggcagc gggatgagcc      360

tgcaggccac cggctcagcc aagaggagat cctggggagc acacggctgg tcagccaagg      420

gctagaggcc ctacgcagtg aacaccaggc cgtgctgcaa agcctgtccc agaccattga      480

gtgtctgcag cagggaggcc atgaggaagg gctggtgcat gagaaggccc ggcagcttcg      540

ccgttctatg gaaaacattg agctcgggct gagtgaggcc caggtgatgc tggctctagc      600

cagccacctg agcacagtgg agtcggagaa acagaagctg cgggctcagg tgcggcggct      660

atgccaggag aaccagtggc tgcgggatga gctggctggc acccagcagc ggctacagcg      720

cagtgaacag gctgtggctc agctggagga ggaaaagaag cacctggagt tcctggggca      780

gctgcggcag tatgatgagg atggacatac ctcggaggag aaagaaggcg atgccaccaa      840

ggattccctg gatgacctct ttcctaatga ggaggaagag gaccccagca atggcttgtc      900

ccgtggtcaa ggtgctacag cagctcagca gggtggatat gagatcccag caaggttgcg      960

gacgttgcac aacctggtga tccagtacgc agcccaaggt cgctatgagg tggccgtgcc     1020

actctgtaag caggcactag aggacctgga gcgcacatca ggccgtggcc accctgatgt     1080

cgccaccatg ctcaacatcc ttgctttggt gtatcgtgac cagaataagt ataaggaagc     1140

tgcccacctg ctgaatgatg cccttagcat ccgggagagc accttgggac ctgaccatcc     1200

tgctgtggct gccacactca acaatttggc tgtgctctat ggcaaaaggg gcaagtacaa     1260

ggaggcagag cctctgtgcc agcgggcact ggagattcga gaaaaggtcc tgggcacgaa     1320

tcatccagat gtggcaaaac agctgaacaa cctggccctc ttgtgccaaa accagggcaa     1380

gtatgaggcc gtggaacgct actaccagcg agcactggcc atctacgagg ggcagctggg     1440

gccggacaac cctaatgtag cccggaccaa gaacaacctg gcttcctgtt acctgaaaca     1500

gggcaaatat gctgaggctg agacactata caaagagatc ctgacccgtg cccatgtaca     1560

ggagtttggg tctgtggatg atgaccacaa gcccatctgg atgcatgcag aggagcggga     1620

ggaaatgagc aaaagccggc accatgaggg tgggacaccc tatgctgagt atggaggctg     1680

gtacaaggcc tgcaaagtga gcagccccac agtgaacact actctgagaa acctgggagc     1740

tctgtatagg cgccagggaa agctggaggc tgctgagacc ctggaggaat gtgccctgcg     1800

gtcccggaga cagggcactg accctatcag ccagacgaag gtggcagagc tgcttgggga     1860

gagtgatggt agaaggacct cccaggaggg ccctggagac agtgtgaaat tcgagggagg     1920

tgaagatgct tctgtggctg tggagtggtc cggggatggc agtgggaccc tgcagaggag     1980

tggctctctt ggcaagatcc gggatgtgct ccgcagaagc agtgaactct tggtgaggaa     2040

gctccagggg actgagcctc ggccctccag cagcaacatg aagcgagcag cctccttgaa     2100

ctatctgaac caacctagtg cagcacccct ccaggtctcc cggggcctca gtgccagcac     2160

catggacctc tcttcaagca gctgacattc aacccggccc ccaggtctgc tgggtccccc     2220

cacccccaca gccctcacag cattccccat tgctcctggc tcttccccac ccctaggtgg     2280

gacagtgaag gggagcagtt taaccagaag attgctgctg cccttagggt ctcagctccc     2340

tcctcaggaa tccctcttag gaaggaccct caggacaccc tctctgcacc ctgtggtcct     2400

ctagagtagc tagctctgag gccccaaggt gggtacaaag caggtatggc cctcagagat     2460

gcagcctgct gctggctttt cagtcagagg gttgggggct ggccagccaa gctgccttgc     2520

cctggccgct cttactccct ccctctgctg tctcacttca ggtccatgta tttcactttt     2580

cttaaataaa agaatcaggt aa                                              2602


<210> 3754
<211> 992
<212> DNA
<213> Homo sapiens

<400> 3754
cgggggcggg gcctggagga gcctacaccg actctggagg aagactggag cctttgcggc       60

ggcgctgccc ctcccctggt ccccgcgagc tcggagggcc cggctggtgc tgcgggggcc      120

ccgggaggtt gaaaactaag catggggaag agctgcaagg tggtcgtgtg tggccaggcg      180

tctgtgggca aaacttcaat cctggagcag cttctgtatg ggaaccatgt agtgggttcg      240

gagatgatcg agacgcagga ggacatctac gtgggctcca ttgagacaga ccggggggtg      300

cgagagcaga tagcagagag tcttttcagc gtgtggagct gctcaagaag gagattgaca      360

aatccaagga caagaaggag gtcaccatcg tggtccttgg caacaagtgt gacttacagg      420

agcagcggcg tgtagaccca gatgtggctc agcactgggc caagtcagag aaggtgaagc      480

tgtgggaggt gtcagtggcg gaccggcgct ccctcctgga gccctttgtc tacttggcca      540

gcaagatgac gcaaccccag agcaagtctg ccttccccct cagccggaag aacaagggca      600

gcggctcctt ggatggctga agagctgccg ttcctctttc acgatcccag ccccatttca      660

gtgtctgggg ctctggtaga tgtgttgagg gcaaagtaga ggacaagctg tctttcccag      720

tcagccaggg agctccccgc caggccacgc cccagccact ttgctccctc tcacctctgg      780

gaagtgcaaa tactcttggt tgacatcccc ttcctcagcc ctcccagcct actccccatc      840

ccagctttta gaggatctgc tccactgtct cctggggcag ttgtgggtca ctgtcccttc      900

cagctgcccc agacaggaag cagagtcacc acgcagcagt gtcccttctt gggtctgagt      960

tcctattata ggtaggggcc ccaccctctg gg                                    992


<210> 3755
<211> 465
<212> DNA
<213> Homo sapiens

<400> 3755
aggaagagtg aataagaggg agaaaatagt tacatgtact gtgagtagaa tttcttagcc       60

ctccttacag cctagaaaaa atgacagatc tcgtagctgt ttgggatgtt gctttaagtg      120

acggagtcca caagatcgaa tttgaacatg ggactacatc aggcaaacga gtagtatatg      180

tagatggaaa ggaagagata agaaaagagt ggatgttcaa attagtgggc aaagaaacat      240

tctatgttgg agctgcaaag acaaaagcga ccataaatat agacgctatc agtggttttg      300

cttatgaata tactctggaa attaatggga aaagtctcaa gaagtatatg gaggacagat      360

caaaaaccac caatacttgg gtattacaca tggatggtga gaactttaga attgttttgg      420

aaaaagatgc tatggacgta tggtgcaatg gtaaaaaatt ggaga                      465


<210> 3756
<211> 1196
<212> DNA
<213> Homo sapiens

<400> 3756
gcactggagg cagtgatttt ggggcagaga attttgcaac acgtggtagt gaactgtgag       60

gagtttgagg ggtctgaaga ctgaaagagt cgaatggttt gttggcagga cctagaagaa      120

tcccttagga tgaagctgag tcttaccaag agcagaacat catgaagtct tgacagaata      180

taaagaagga gttggaaagt ttatagtctg tgtctgtgtg gagtgttgca ggacgagtgg      240

aaatgactgt ttccaagttc atggcaattc agaaggccct tcagccagac tggttccagt      300

gcctctccga tggagaagta tcttgtaagg aagcaacttc cataaaaagg gtcagaaagt      360

ctgttgaccg atcacttctt ttcttggata actgtctgcg gctgcaggaa gagtcagagg      420

ttcttcagaa gagtgtgatc attggagtga ttgaaggtgg agatgtgatg gaagagaggc      480

tgaggtcagc acgagagaca gccaagcggc ctgtgggtgg cttccttctg gatggttttc      540

aaggaaatcc aacaaccctg gaggctagac tacgcttgct gtcatcagtc actgcagagc      600

tgccggagga caagccaagg ctcatatctg gtgttagtcg gccagatgag gtgctcgagt      660

gtattgaaag aggagtggac ttatttgaga gttttttccc ttatcaagta acagagcggg      720

gatgtgccct gactttcagt tttgattacc agccgaatcc tgaagagaca ctactacaac      780

aaaatggaac acaagaagaa ataaaatgta tggatcaaat aaagaaaatt gaaacaactg      840

gttgcaacca agaaataaca tcatttgaaa ttaatctgaa ggaaaaaaag taccaggagg      900

actttaaccc gctggtgaga ggatgttcct gttactgctg taagaatcac actcgggcat      960

acatccacca tctgctggtg accaatgagc tgctggccgg agtcctgctt atgatgcaca     1020

actttgaaca ctactttggg tttttccatt acatccggga agcactaaaa agtgacaaac     1080

tggcacagtt gaaagagctc atccacaggc aagcatcttg agatcttgca aatacaagtc     1140

tcactcttca cactgagcct gtaccactgt tgtaacatgg gaagacgtga agaaga         1196


<210> 3757
<211> 1928
<212> DNA
<213> Homo sapiens

<400> 3757
ggcttcttgg cgcgatgagg ttccggttct gtggtgatct ggactgtccc gactgggtcc       60

tggcagaaat cagcacgctg gccaagatgt cctctgtgaa gttgcggctg ctctgcagcc      120

aggtactaaa ggagctgctg ggacagggga ttgattatga gaagatcctg aagctcacgg      180

ctgacgccaa gtttgagtca ggcgatgtga aggccacagt ggcagtgctg agtttcatcc      240

tctccagtgc ggccaagcac agtgtcgatg gcgaatcctt gtccagtgaa ctgcagcagc      300

tggggctgcc caaagagcac gcggccagcc tgtgccgctg ttatgaggag aagcaaagcc      360

ccttgcagaa gcacttgcgg gtctgcagcc tacgcatgaa taggttggca ggtgtgggct      420

ggcgggtgga ctacaccctg agctccagcc tgctgcaatc cgtggaagag cccatggtgc      480

acctgcggct ggaggtggca gctgccccag ggaccccagc ccagcctgtt gccatgtccc      540

tctcagcaga caagttccag gtcctcctgg cagaactgaa gcaggcccag accctgatga      600

gctccctggg ctgaggagaa gggtgttcca ggcctgtgtg gagccgccct gcccgtatgg      660

agtcacgccc tctgaactgc tcttcgggag gcagccctgg ttctaggatg ctgaggccct      720

ggcccggact ctggcctccc agatccccag ctgcctcact tctctcttga gaacttggct      780

cagggctcct gaggaccttt cccagcatta ccttcccttc ccttgaaagt agagatgagg      840

tttctccatg ttggtcaggc tggtctcgaa ctcctgacct caggtgatcc acccaccttg      900

ccctcccaaa gtgctgggat tacaggcgta agccactgcg cccagccact gccatcatct      960

ttaggaagag agaagtgacc atgcctgaac cagtcattgg caagaggaac ggtgttatgg     1020

actgaatgtt catgttcctc cagaattcat atgctgaagc ctctgtccac acatgcacac     1080

cagatgaggg ccatgtgcgc acacgaggtg gctgtctaca aggccagaaa gagggctgtc     1140

aacaggaact gcgtctgctg gcaccttgat cttgaacttc ccagcctcca gaactgtgag     1200

aaagaaatct ctatggtgta agccactagt ctgtggcatt gttatagcag ctcgagaaga     1260

ctaaggcaga tgggcttcca ggactggccc agaccagcca gggctccttg tagaaaaggc     1320

tgatgccagg gttggcacat ggagggtaca aggaggactc gcctggagta tcttaaggaa     1380

cctatcgaag aataatggct tgttccactg gccaaagatg ggacaatttg aacatcaaaa     1440

gagatactta ctgactccac tcctgacttc tgcttctgaa aaaatgaagt aggtgttttc     1500

cctattcctc ccactaagta cagttaacaa ccctggatgt tacatataaa acaaacaaaa     1560

agactccgag cgatggagag aaggcaccct agcctggctg ggatcctcag gacctgaggc     1620

tccacagaga gaaattcctg gaatctggac cccatggccc agtcaggtta cacaaaactg     1680

atcatcacag atctgtagaa ctatacaaaa gtgctaacat tcatgattag ggtctcagaa     1740

ggtaaggagg aagagagtgg aatggaaaaa gtattcaaaa aaataatcac taaaggccag     1800

gtgcagtggc ccatgcctgt aatcccagca ctttgggagg tgggacaatt gctttagacc     1860

ttgcaactgg cctgagcaac acagggagac tcagtttctc caaaaaaata aaaaattagc     1920

cgatcatg                                                              1928


<210> 3758
<211> 591
<212> DNA
<213> Homo sapiens

<400> 3758
aagtatgaaa caatgacgat ttcatgatgg ctcattgttc tttggtattg tgccttacgt       60

gagctgggga ctaactctaa atcagttttt atttcactta ggtggttccg gggagaagcc      120

tttccaggac ccatgtgtag gcacaactgt tttccctgat caggatactt gcggcactca      180

acagaggaaa gaaattccta agggaacact gctcagaaag tactgcagca tgtcttcaaa      240

tgcctgagga tcaagttgga aaactagaag caacagaaaa cacaataagc gcaatggcgg      300

cggccgcggc ggagcagcaa cagttctacc tgctcctggg aaacctgctc agccccgaca      360

atgtggtccg gaaacaggca gaggaaacct atgagaatat cccaggccag tcaaagatca      420

cattcctctt acaagccatc agaaatacaa cagctgctga agaggctaga caaatggccg      480

ccgttctcct aagacgtctc ttgtcctctg catttgatga agtctatcca gcacttccct      540

ctgatgttca gactgccatc aagagtgagc tactcatgat tattcagatg g               591


<210> 3759
<211> 1725
<212> DNA
<213> Homo sapiens

<400> 3759
cactaaacta gcaacaggat caaaagatac aacagttatc atatggcaag ttgatccgga       60

tacacacctg ctaaaactgc ttaaaacatt agaaggacat gcttatggcg tttcttatat      120

tgcatggagt ccagatgaca actatcttgt tgcttgtggc ccagatgact gctctgagct      180

ttggctttgg aatgtacaaa caggagaact aaggacaaaa atgagccagt ctcatgaaga      240

cagtttgaca agtgtggctt ggaatccaga tgggaagcgc tttgtgactg gaggtcagcg      300

tgggcagttc tatcagtgtg acttagatgg taatctcctt gactcctggg aaggggtaag      360

agtgcaatgc ctttggtgct tgagtgatgg aaagactgtt ctggcatcag atacacacca      420

gcgaattcgg ggctataact tcgaggacct tacagatagg aacatagtac aagaagatca      480

tcctattatg tcttttacta tttcaaaaaa tggccgatta gctttgttaa atgtagcaac      540

tcagggagtt catttatggg acttgcaaga cagagtttta gtaagaaagt atcaaggtgt      600

tacacaaggg ttttatacaa ttcattcatg ttttggaggc cataatgaag acttcatcgc      660

tagtggcagt gaagatcaca aggtttacat ctggcacaaa cgtagtgaac tgccaattgc      720

ggagctgaca gggcacacac gtacagtaaa ctgtgtgagc tggaacccac agattccatc      780

catgatggcc agcgcctcag atgatggcac tgttagaata tggggaccag caccttttat      840

agaccaccag aatattgaag aggaatgcag tagcatggat agttgatgga tgttggttcc      900

tgcaaacaag aactgaccct atcacctctg cctcacagtg ggtaaatata tcatacatct      960

cttgaaaggg aaaatatcca tgtcagtttc tttcacagta gaagaatggc tgcttttgaa     1020

tggggaggaa agaagacatt tttcttaata tcctttttgt cccatctcta aaatgtataa     1080

atattttgat ttggttttac tttaatttct cattcataat ttcgcaactg tccttttggg     1140

ttgccctcca acacattact tccatttcag aaaccatatc tgatttaata taaactgcta     1200

acttaagaag aggtgaattt gcatttacac ttagacactt tctaaaaaca gggtgaactt     1260

aattgaaatt tttcagtgtt gttaagctat tgttatagta gctgccctat agttacaaaa     1320

ataaaaacta taaaaaccca tcccctatct acttaatcca gatagcctgg atttaacaaa     1380

accaatagta taaaaatgtg tgtgtgtgtt ctgtgtgtgt gtgagagaga gagtacttga     1440

ttcattaaaa agtcctggaa acagctgttc taggatcttg tcatttttac tgaaagtctc     1500

gtgcacatgt gaagtgccct ctgagtttaa ggtttggtta atactggtat atttttataa     1560

gattgaaatt gtgtccccat ctttaactta aacattttca ttatcagggt caatgtgcta     1620

gaactgaatt gtaacatttt taggcacaga tggaaaaaaa tgttattggc tccttgaaaa     1680

tgtgtgtgtg tggcgagggg aatagatcca caaaagcatg tatgt                     1725


<210> 3760
<211> 2166
<212> DNA
<213> Homo sapiens

<400> 3760
ggcccgcgga gtccagcgaa gtttggcgga acatggcgga agcgtctggg gcacgcagga       60

gcgcggggcg gcggcggccg gagcccgagg agctgtagca gccttagtcg ccgccgccgc      120

ggggcgaggt cgccgccatg gcccgctgga tcccgaccaa gaggcagaag tacggggttg      180

cgatctataa ctacaatgct tctcaagatg tggagctctc cttgcagatc ggtgacacag      240

ttcacatcct ggagatgtac gagggttggt acagaggata taccctccaa aataaatcta      300

aaaagggcat tttccctgaa acatatatcc atttgaaaga ggcaactgtg gaagacctgg      360

ggcagcatga aaccgtgatt cctggcgagc tccccctggt gcaggagctc acgtccactc      420

tgcgagaatg ggctgtcatc tggcgaaagc tctacgtgaa caacaagctc accctcttcc      480

gccagctgca gcagatgacg tacagcctga tcgagtggcg gtcccagatc ctgtctggga      540

cgctccccaa ggatgaactg gcagagctca agaagaaagt cacagccaaa attgatcatg      600

ggaacagaat gctggggtta gatctggtgg tgcgagatga caatgggaac atcctagacc      660

ctgacgaaac cagcaccatt gccctcttca aggcccatga ggtggcctcc aaaaggattg      720

aggaaaagat ccaagaagag aagtcaatcc tgcagaacct cgatttgcgg ggccagtcca      780

tcttcagtac catccacacc tatggcctct atgtgaactt caagaacttt gtctgcaaca      840

tcggggaaga tgcagagttg tttatggccc tctacgaccc agaccagtcc acttttatca      900

gtgagaacta tctaattcgt tggggcagta acgggatgcc caaggaaata gagaagctca      960

ataacctcca agcagtgttt acagacctta gcagcatgga cctcatccgg ccccgcgtca     1020

gccttgtgtg ccagattgtc cgcgtgggcc atatggagct gaaggaaggc aagaagcaca     1080

cctgtggact ccgaagacct tttggagtgg cagtgatgga tattactgat atcatacatg     1140

ggaaggtgga tgatgaagaa aagcagcatt ttattccctt tcagcagtaa gtactttggc     1200

atgtgtccca ggtgacttga gacctggatt agccattcaa ttgtctttta acacagaaac     1260

aggtgttaga aaccattttc tcagagaagg aaagattcta agctgcaaga ttgtcagata     1320

ggagctgaac agaagacttt attcaaagtc cttgatgttg gactcccatt gaagagggta     1380

aactgaactt tcctgattct atagaaagca tcaaaggaat ataaaagggc acatatctgt     1440

ctgctctgga atgcagagag ggtgccgtcc ttgtgtcagc aatgccaaaa tatatgtgca     1500

gtctattgca tgaaacaggc atcatggatg acacggaatc acgtgggcta gcatagggct     1560

tctcagactg catcatgcat atgaatcagg ggaacttgtt aggctgcagg ggagttctgc     1620

ctctgacaag ctcccaggtg atgctgatgt agctggtctg agggccacac tgtctgtagc     1680

gagggtttag gagatgagag agtgaagggc tgacccaccc atgggccagt gttcctgcat     1740

gttgggggaa agccagcctg ggagcatgtg aaaggatcct tgcagagctt tactgaggcc     1800

ctccatattg agctgcagga gctggagcca tgggtaggcc attgaggagc tgttgggagc     1860

agattcaagc cgtgtcactc tgaagaagtg caggtgtgaa cgtcatgacc tgctccagca     1920

cctgcacagg cagtggaggc ctagtggagg ccaagagcat tgccgggacc aagtcccacc     1980

aggggccatc gtgccagtca gagggcatca tctcagctca cttgcagctg ccactgcaga     2040

caagtagaac aaactgagaa ttccacaaac cagccagagt catatatttg agttaatata     2100

tcacttttta caaatgatat cacaaattag tggagaaaga tacattatgc aaaaaaaaaa     2160

aaaaaa                                                                2166


<210> 3761
<211> 555
<212> DNA
<213> Homo sapiens

<400> 3761
gacctcccac aactggagca gccgggaaca gctctgacca catttttatt tcacttaggt       60

ggttccgggg agaagccttt ccaggaccca tgtgtaggca caactgtttt ccctgatcag      120

gatacttgcg gcactcaaca gaggaaagaa attcctaagg gaacactgct cagaaagtac      180

tgcagcatgt cttcaaatgc ctgaggatca agttggaaaa ctagaagcaa cagaaaacac      240

aataagcgca atggcggcgg ccgcggcgga gcagcaacag ttctacctgc tcctgggaaa      300

cctgctcagc cccgacaatg tggtccggaa acaggcagag gaaacctatg agaatatccc      360

aggccagtca aagatcacat tcctcttaca agccatcaga aatacaacag ctgctgaaga      420

ggctagacaa atggccgccg ttctcctaag acgtctcttg tcctctgcat ttgatgaagt      480

ctatccagca cttccctctg atgttcagac tgccatcaag agtgagctac tcatgattat      540

tcagatggaa acaca                                                       555


<210> 3762
<211> 549
<212> DNA
<213> Homo sapiens

<400> 3762
agcacctttg ttcctactat agtcttcctt tatttaagtc agttcatctc cctctcgctt       60

tgcccacaac cttagctttg agtttagtga tctaagctcc ctgcctgctg gtcactctct      120

ctctccagct aagccacagg gtcactctta cttttgtccc ttcacttgga ttcccaccac      180

tctctgagaa agttgctcag cttctctgtc tcatctttac accagctgaa ctctgttgtt      240

tctccctaga ccgggcaagg tcccccaggc caggatgtca ggcctggtgt tggggcagcg      300

ggatgagcct gcaggccacc ggctcagcca agaggagatc ctggggagca cacggctggt      360

cagccaaggg ctagaggccc tacgcagtga acaccaggcc gtgctgcaaa gcctgtccca      420

gaccattgag tgtctgcagc agggaggcca tgaggaaggg ctggtgcatg agaaggcccg      480

gcagcttcgc cgttctatgg aaaacattga gctcgggctg agtgaggccc aggtgatgct      540

ggctctagc                                                              549


<210> 3763
<211> 588
<212> DNA
<213> Homo sapiens

<400> 3763
gttgtgagct gcggcagaga ctggtggctg gaggagacgc cggcgctgga gagtgcgctg       60

cgccgcccgc cgctgaggga ccgcggggtt agccactgct ggctgcttcc agtgttcgcc      120

gagagccaca taaagaagat ccctaatagt catttctcaa caattatata gtcaactgat      180

gtaacaatgg tactaatatt gggacgcaga ctaaacagag aggatcttgg ggtgcgtgat      240

tccccagcaa ctaagcgaaa agtttttgaa atggacccca aatctctgac aggtcatgag      300

ttttttgact tctcttcagg atcatcccat gccgaaaaca tactccagat atttaatgaa      360

tttcgtgata gccgcttatt cacagatgtt atcatttgtg tggaaggaaa agaatttcct      420

tgccatagag ctgtgctctc agcctgtagc agctacttca gagctatgtt ttgtaatgac      480

cacagggaaa gccgagaaat gttggttgag atcaatggta ttttagctga agctatggaa      540

tgttttttgc agtatgttta tactggaaag gtgaagatca ctacagag                   588


<210> 3764
<211> 1917
<212> DNA
<213> Homo sapiens

<400> 3764
agatcagaaa agggagctca ggtaccttcc agagagtgag acccagcgcc cttgtctcgc       60

acccagtagg ctttcatccc cgccatggcg gagctgatcc agaagaagct acagggagaa      120

gtggagaaat atcaacagct acagaaggac ttaagtaaat ccatgtcggg gaggcagaaa      180

cttgaagcac aactaacaga aaataatatc gtgaaagagg aactggccct gctggatggg      240

tccaacgtgg tctttaaact tctgggtccg gtgctagtca aacaggagct gggggaggct      300

cgggccacag tagggaagag gctggactat atcacagctg aaatatttct gaggacaatc      360

ccagacccag gagatgttcc agactcattt ttctgatatt cagagagggc aagagtcttg      420

gcctatgtca cacagcagag tccaggactc cagaactcca acctagcact ctggccagaa      480

agtcagccag aggaaggaaa actgggaatg aagagtcaga ggtgagaagc taaagtcatg      540

atctcaccaa gggatcaaga ggtcgatatt ggcggcttgt gacggtaaac acggcaccat      600

cctcctcctc atcccagacg gacacagggg cctggaggag caaggaaggg gaagtcagac      660

agttccacac caccccccat tgccctcagc cttcacccca ggccctgctc ctccctctgt      720

acccctcacc tgtggtggca gggcatagta ccagcgagtg cgaggaaggg ttgggggagc      780

tggtgacccc aggtctcccc cactggggcc cagacagccc caccccagcc gcctcagggc      840

cccggtggag tcgaaggggc tgcagtggag gcgtggatgg agtacaggaa ttctgatcct      900

ggagaccccc aaagcccctt ctccccagag ctgaacccac acacgacaga gaagcagggt      960

acaaagggca ggagagggaa gcgagaggca gcaagccaga ggcagcgact aggggtagct     1020

gaaacctcag tccaggcact gccgcatgcc ccgcccctcc cggccaagga ctataccagc     1080

ccagagaatt agtctttttc aggacccctt tcaccctggt ccctcgggta gcgcctccac     1140

tatctcagcc ctaagggacc cccgaaggta gcagctccaa tcccagtaca ggaaggaaaa     1200

ggggaagtgg gatgataggg ggttgggggc ggtagactca gagagtcacg tggccccagc     1260

ccctcccccg accgatcccg aaaaaccagc cctgccagtc aacctgccct cacctaggat     1320

ctggacctag gagtttaggg cctcggggcc ccaaatccaa attctggccc ctcctgaggc     1380

ccgaaatcct gctcctggcc accaccatta atccctaatg aaaacagatg accactctct     1440

acccacccta ggatctttcc tccaggtccc agaaccgtgg cttcccggcc tctacccagg     1500

accggggcgg ggcggggggg cggggggaag ggggagagag ggaaggaggg gtcacgaaat     1560

ctgagggttc cctccccaat cccagagtca gaggagctgg ttactgtgga aacaaacccc     1620

tccccgccaa acaaaaacaa ggagggagac agggaccaag acacgactgc tcagagaggt     1680

aggcacactc aggcaggcag aggtggaggg ccaaagaccc gcagggacag gacagccagc     1740

cagaagttcc aggcaggaac agggcaggtt cctgcgggca ggtcctgagt cacactgaca     1800

gagaaccacg gagacgccag gactccccgc agcagagaaa cgggccgaca cccagggagg     1860

cgcgagaata actgaggcaa ggaggaggag atgtagggac ccagagacaa gagaaaa        1917


<210> 3765
<211> 2010
<212> DNA
<213> Homo sapiens

<400> 3765
gcgcagaggc gtcacgcact ccatggtaac gacgctcggc ccgaagatgg cggccgaatg       60

gggcggagga gtgggttact cgggctcagg cccgggccgg agccggtggc gctggagcgg      120

gtcataaata aagttcatct taaggcaaat catgtggtca agagagatgt tgatgagcat      180

ttaagaatca agactgtcta tgataaaagt gttgaagagt tgctccctga gaaaaagaat      240

cttgtaaaga acaagctttt cccacaagcg atttcttatt tagagaagac ttttcaggtc      300

cgtcgacctg cgggcactat cttacttagc agacaatgtg caacaaacca atacctccgg      360

aaggaaaacg atcctcacag gtactgcacc ggggagtgtg ccgcacacac aaagtgcggc      420

cccgttattg ttcctgagga acatctccag caatgccggg tctaccgtgg gggtaagtgg      480

cctcatggag cagtgggtgt gccagaccaa gaaggcatct cagatgcaga ctttgttctt      540

tacgttggtg ctctggccac cgagagatgc agccatgaaa acatcatctc ttatgcagcc      600

tattgtcagc aggaagcaaa catggacagg ccaatagcag gatatgctaa cctgtgtcca      660

aatatgatct ctacccagcc tcaggagttt gttgggatgc tgtccacagt gaaacatgag      720

gttattcatg ccctgggttt ctctgctggg ctgtttgcat tctaccatga taaagatgga      780

aatcctctca cttcaagatt tgcagatggc ctcccacctt ttaattatag tctgggatta      840

tatcaatgga gtgataaagt agttcgaaaa gtggagagat tatgggatgt tcgagataat      900

aagatagttc gtcacactgt gtatctcctg gtaacgcctc gtgttgttga ggaagcacga      960

aaacattttg attgtccagt tctagaggga atggaacttg aaaatcaagg tggtgtgggc     1020

actgagctca accattggga aaaaaggtta ttagagaatg aagcgatgac tggttctcac     1080

actcagaatc gagtactctc tcgaatcact ctggcattaa tggaggacac tggctggtat     1140

aaagcaaatt acagcatggc tgagaagtta gactggggcc gaggaatggg ctgtgacttt     1200

gtcaggaaga gctgtaaatt ctggattgat cagcagagac aaaagagaca gatgctgagc     1260

ccttactgtg acacgctcag aagtaaccca ctgcagctaa cttgcagaca ggaccagaga     1320

gcagttgccg tgtgtaattt gcagaagttc cctaagcctt taccacagga ataccagtac     1380

tttgatgaac tcagtggaat acctgcagaa gatttgcctt attatggtgg ctccgtggaa     1440

attgctgact actgcccttt cagtcaggaa ttcagttggc atttaagtgg tgaatatcag     1500

cgcagctcag attgtagaat attggaaaat caaccagaaa tttttaagaa ctatggcgct     1560

gaaaagtatg gacctcattc cgtttgtcta attcagaaat cagcattcgt tatggagaag     1620

tgtgagagga agctgagtta cccagactgg ggaagcggat gctatcaggt ttcttgttct     1680

cctcaaggtc tgaaagtttg ggtccaagat acttcatatt tgtgtagtcg ggctgggcag     1740

gtcctccctg tcagtatcca gatgaatggc tggattcacg atggaaacct gctctgccca     1800

tcatgttggg acttctgtga gctctgtcct ccagaaacag atcctccagc cactaacctg     1860

acccgagctc tgccacttga tctttgttcc tgttcctcga gcctggtggt caccctctgg     1920

cttctgctag gcaatctgtt tcctctgctg gctggatttc ttctgtgtat atggcactag     1980

gaatggaaaa gtggatcttc aagatattct                                      2010


<210> 3766
<211> 1799
<212> DNA
<213> Homo sapiens

<400> 3766
agattgctag tttcctcaca gagctccagt ccacactcgg ccctgaacgc ggagttgaat       60

cagctggctg aagctgagtg cctctctttt cctttcttgg gaacaggaaa ggtgctgtgg      120

agaggaattg gggcgggatc attcagggga aggtgacagc agatggtggg aaggccggag      180

tcagcaagcc aagtgtcagg ggcagagtga gcctcagaaa acagcagctg cccggtgcca      240

gagcaaggaa aggccaggga ggctgggcgg ggcagtgtct gtgggacaga gtggggcaag      300

aacacacacg gccgggcaca gcctcttagc cagctctcca tgtcagtatg agcagtaacc      360

agggaactgg gcaattggca catcagccta tcagaattca tgggaggtta tttcttaagt      420

gaaattctaa agagttaaag gatgaatttg gacagtgatg gaatggatga catcatcagt      480

caagaatcct cattggatat ggaggggaat tataaaaagg cacagaaaaa tgagagagag      540

tctatcagac agaagttggc acttggaagc ttctttgatg atggcccagg aatttatacc      600

agctgtagca aaagtgggaa gccaagcctt tcctcccgac tgcagagtgg gatgaacttg      660

cagatatgct ttgtcaacga cagtggcagt gataaggaca gtgatgctga tgacagtaag      720

actgaaacca gcttggacac ccccttgtct cccatgagca aacagagttc ttcctattct      780

gatagagaca ctactgaaga ggagtctgaa tccttggatg acatggactt ccttacaagg      840

caaaagaaat tgcaagctga agccaaaatg gcccttgcca tggccaaacc aatggccaaa      900

atgcaagtag aagtggagaa acagaacagg aaaaagtctc ccgtcgctga tcttctgcca      960

cacatgcctc atataagtga atgcttgatg aaaagaagtt taaaacccac cgacctgaga     1020

gacatgacta ttgggcagct acaagtgata gtcaatgatc tccattccca gatagaaagc     1080

ttgaatgaag agttggtcca gctgcttctc atccgagatg agctgcacac agagcaggat     1140

gccatgctgg tggacattga agacttgacc agacatgctg aaagtcagca gaagcacatg     1200

gcagagaaaa tgcctgcaaa gtgaaaagaa gccattcaac cagagaacaa gctagaattt     1260

attttgcttc tgtggttgta aaaatgctgt tgctaaaggt ggcgcagaaa caaatatcag     1320

tgttagtcat tgataatgtc tgaagcttaa tgtccagtga ttggcctttg cttcttaatt     1380

tattttaatt ttttacttgt gccacttaat atcaggcatt ttaataaaat attgttacaa     1440

aaaatgtaca gtactgacac caccacaaat catggttaat aaaagagagt agttttaact     1500

ttatttttat ttgtttagag attttaagtt ggaacagtat tttcccattg actacttttc     1560

attcttcact gtagttttaa agaagaactg taaatgacgg tgctatacaa gtcaaaaaat     1620

acatgcctgc ctcgtagtga agttgtagct ctccgtaata tgtatatttt actcagtttt     1680

caacattttg tgaatgttga ctacctgaag ttccttttta gatgtgctat taacattctg     1740

ttggattcag agggttcctt gaaagtttta tgtataaata tgtaaaataa aaattaaaa      1799


<210> 3767
<211> 2056
<212> DNA
<213> Homo sapiens

<400> 3767
cccggcgcca gcggccgcgt cggcgcggat gtccccgccc gcctctggtt cgggcctcag       60

cgagattact ggaggattag atccggatcc cgtccccggg cagcggccgc cgcggccagc      120

gccgccccgc gagttgcgag ctccgggctg gccctgctct gacaggctcg ccccgcccca      180

cacgacacgc ctgccactcc tgcccccagg tcgctgaaga gttcgaaacc gtgctcagca      240

ccgcgtttgg ggcatgtgag accgagaggc tttgggaaac tgacgccgct gtgagaacga      300

gtttagcgga gtctatggac gctgcgagct tgtggccaca agagggcgcc ccggagcacg      360

gcccagtccc cgcccccgct ggatggggcc cggcctcttc ccagcgttcc tcctccggcc      420

ccaggtcacc gccagcacgc gcctgcttcc cgtctgcgcg agtccacgca gctccccagg      480

cccttcacca gcacagcagc agcaggcatg gcagcaagcg tggagcagcg cgagggcacc      540

atccaggtgc agggccaggc cctcttcttc cgagaggccc tgcccggcag tgggcaggct      600

cgcttctctg tactgctgct gcatggtatt cgcttctcct ccgagacctg gcagaacctg      660

ggtacactgc acaggctggc ccaggctggc taccgggctg tggccattga cctgccaggt      720

ctggggcact ccaaggaagc agcagcccct gcccctattg gggagctggc ccctggcagc      780

ttcctggcgg ctgtggtgga tgccttggag ctgggccccc cggttgtgat cagtccatca      840

ctgagtggca tgtactccct gcccttcctc acggcccctg gctcccagct cccgggcttt      900

gtgccagtgg cccccatctg cactgacaaa atcaatgctg ccaactatgc cagtgtgaag      960

actccagctc tgattgtata tggagaccag gaccccatgg gtcagaccag ctttgagcac     1020

ctgaagcagc tgcccaacca ccgggtgctg atcatgaagg gggcggggca cccctgttac     1080

ctggacaaac cagaggagtg gcatacaggg ctgctggact tcctgcaggg gctccagtga     1140

agcccagcac tgctgcaggg ggtgggctgc ctgcctgctc tgagctctct cttgcacgct     1200

ctctcttctc tcccaggctc tggctcatgc acatgcaaca ggtgcgtctg tctatatgtc     1260

tgggttcttg tcttttgtgg tctgtttgtc ttttctacct ctttctcttg cagtgataga     1320

ctgagggggt aaaatcaaga gaaaaaactc tcaggaatca aggaacataa tcctgtggag     1380

ggtaatccat tacatgagct tctcctgttc ttccactttc ctgcctggct ttcactcctt     1440

cccctgctct gcccagcctt tccctcccac ccactcctcc ttctgcaaat gccctgaagg     1500

ccagccctta ccccaacacc cacttcccca cctccttagg ccccagatac atacatgccc     1560

acatgcacgc ttacatgttt agagccatcc ttgtttccaa atatgaccct tcgcttgagg     1620

gcaactgcat aggtacatct aactctggac tggcatgcac attgtcatgt gcagctttgc     1680

atatacacac atgcatacat gagcctccac acaagcactt gcacacatgt ggactcctaa     1740

ccatgctaac ctcactggct gggaaggtgg ggaccccatg ggccagccct tgcaggaggc     1800

ccttttgcaa ggcttagggt gtggccagcc ctgaaagcta cttggacaca ggtttcagct     1860

ggccccagcc cagaagtgac ccccagaaag ggagggccac cgctttgccc cctgctttta     1920

cccttccttc tgggtgctct acacctcagg ttaccaggcc tgaggcatct cagccaagct     1980

tgtttcctgc tctgaggctt gtggggtggg agccagagtg gaggtcggtg aaataaagtg     2040

atgcaattag acccca                                                     2056


<210> 3768
<211> 597
<212> DNA
<213> Homo sapiens

<400> 3768
aatgtgtttg agaaaactgt tttcctcgga catgcaggcg tggactcctt acttcaggta       60

aggtgacagc agcttgacag agagtgcctt ccctcccacg gcatttggga cgaggctgaa      120

ggaaagacac aggcggggtt acgggaaacc cattctctgc gccatctggg caagctgaag      180

tcagtttttc cgctttctca cgagacacgt ctgcctctat gaaccagcgc agccatctgg      240

gcaccaccta cctggacacg gccaaaggcg cggtagagac cttcatgaag ctccgtgccc      300

gggaccctgc cagcagagga gacaggtata tgctggtcac tttcgaagag ccgccctatg      360

ctatcaaggc tggatggaaa gaaaaccatg caacgtttat gaatgaattg aaaaaccttc      420

aggctgaagg acttacgact cttggccaat ccctaaggac agcttttgat ttattaaatt      480

taaatagatt agtaactggc atagacaact atgggcaggg aagaaaccct tttttcttgg      540

agccagcaat aattatcaca attactgatg ggagcaagtt gactaccacc agtggag         597


<210> 3769
<211> 1755
<212> DNA
<213> Homo sapiens

<400> 3769
aggcgcagtc ccgcgttccc tcggcggctg ccggcgtagt gagcccgccg ccgtggagtg       60

tagcggaaag ggctcgccgt cctcctccgt ttctcgctgc ttcgggacgc gctctctgcg      120

gctctgtgag cgcccctgag cgccggcagc ggccgcggtg ggttcttcag gttatcttat      180

gatgaggctt ttgctatggc taatgatccc ttggaaggct tccatgaagt aaaccttgct      240

tcacctactt ctccggacct tcttggtgtg tatgaatcag gaactcaaga gcagactacc      300

tcaccaagtg tcatctaccg gccacaccct tcagctttat cctctgtacc tatccaggca      360

aatgcattag atgtttctga acttcctaca caacccgtgt attcatcccc cagacgttta      420

aattgtgcgg aaatatctag tatcagcttt catgttacag acccagcccc ttgctctacc      480

tctggagtca cagctggatt aactaaatta actacaagaa aggacaacta taatgcagag      540

agagagtttt tacagggtgc tactataaca gaggcttgcg atggcagtga tgatattttt      600

gggttgagta ctgatagtct gtctcgttta cgaagcccat ctgttttgga agttagagaa      660

aagggctatg aacgattaaa agaagaactc gcaaaagctc agagggaact gaagttaaaa      720

gatgaagaat gtgagaggct ttcaaaagtg cgagatcaac ttggacagga attggaagaa      780

ctcacagcta gtctatttga ggaagctcat aaaatggtga gagaagcaaa tatcaagcag      840

gcaacagcag aaaaacagct aaaagaagca caaggaaaaa ttgatgtact tcaagctgaa      900

gtagctgcat tgaagacact tgtattgtcc agttctccaa catcacctac gcaggagcct      960

ttgccaggtg gaaagacacc ttttaaaaag gggcatacaa gaaataaaag cacaagcagt     1020

gctatgagtg gcagtcatca ggacctcagt gtgatacagc caattgtaaa agactgcaaa     1080

gaggctgact tatccttgta taatgaattc cgattgtgga aggatgagcc cacaatggac     1140

aggacgtgtc ctttcttaga caaaatctac caggaagata tctttccatg tttaacattc     1200

tcaaaaagtg agttggcttc agctgttctg gaggctgtgg aaaacaatac tctaagcatt     1260

gaaccagtgg gattacaacc tatccggttt gtgaaagctt ctgcagttga atgcggagga     1320

ccaaaatcac ttctgtatgt aactttttta catacattcg atacattcag cagggactcg     1380

tgaaacagca ggatgttgat cagatgtttt gggaggttat gcagttgaga aaagagatgt     1440

cattggcaaa gctgggttat ttcaaagagg aactctgatg ctctgcgtgg gaccatgcct     1500

gaactccccg aataactgaa aaatggctga atatttttat ggttacttga tatttatttc     1560

caaggagtga gcctaagact tttttcccct tttgcaaatt gctctaagaa gtaccatgat     1620

ttcttttaaa ctgatctatg ctgtgtttgc ttattcttta gttgaacaca ctatgaagaa     1680

ttccaggtgt actagtgaat gtaatttata gttgccaaaa aaaaaaaaaa cctgaaataa     1740

ataaatgtta gattg                                                      1755


<210> 3770
<211> 825
<212> DNA
<213> Homo sapiens

<400> 3770
cttgtacctg tcgttcgcag tggctcactt tcccaagcca tgggcagcag gaagaaggaa       60

attgccctgc aggtcaacat cagcacccaa gagctttggg aggaaatgct cagttccaaa      120

ggactaactg ttgttgatgt ctatcaaggc tggtgtggcc cctgcaaacc tgtggtgagc      180

ctcttccaga agatgaggat cgaggtcggc ctggaccttc tgcactttgc attaattaaa      240

gatgaggctc tttctgatga agatgaatgt gtttcccatg gaaagaataa tggtgaagat      300

gaggacatgg tttcatcaga gaggacctgt accttggcca tcattaaacc agatgcagtg      360

gcccatggaa agactgatga gattatcatg aagattcagg aagctgggtt tgaaattcta      420

acaaatgaag agagaaccat gacagaggca gaagtgcgac ttttctacca acacaaagct      480

ggagaggagg catttgagaa gctggtacat cacatgtgca gtggaccaag ccacctcctg      540

atcctcacca ggactgaggg cttcgaggac gtggtcacta cctggcgaac cgtcatgggc      600

ccccgtgacc ccaatgtggc caggagggag cagccagaaa gtctccgagc tcagtacggc      660

acagaaatgc ccttcaatgc cgtccatgga agccgggaca gagaagatgc tgacagagaa      720

ctggcattgc tcttccccag tttgaaattt tcagacaaag atacagaagc ccctcagggt      780

gagtccagta cacagccaag gttgaagatc actgacctag actaa                      825


<210> 3771
<211> 3844
<212> DNA
<213> Homo sapiens

<400> 3771
gcagtactcc ctgattggct ctgcactgga ggcagtgatt ttggggcaga gaattttgca       60

acacgtggta gtgaactgtg aggagtttga ggggtctgaa gactgaaaga gtcgaatggt      120

ttgttggcag gacctagaag aatcccttag gatgaagctg agtcttacca aggtagttaa      180

tggctgtcgc ctaggaaaaa taaaaaacct gggcaaaaca ggggaccaca ccatggatat      240

tccaggctgc cttctgtata ccaagactgg ctccgcccca cacctcaccc atcacacgct      300

gcataatatc cacggggttc ctgccatggc tcagcttacg ctgtcatccc tagcagaaca      360

tcatgaagtc ttgacagaat ataaagaagg agttggaaag tttataggca tgccagaatc      420

actcttgtac tgctccctgc acgatccagt cagcccctgc ccggctggtt atgtaacaaa      480

caagtctgtg tctgtgtgga gtgttgcagg acgagtggaa atgactgttt ccaagttcat      540

ggcaattcag aaggcccttc agccagactg gttccagtgc ctctccgatg gagaagtatc      600

ttgtaaggaa gcaacttcca taaaaagggt cagaaagtct gttgaccgat cacttctttt      660

cttggataac tgtctgcggc tgcaggaaga gtcagaggtt cttcagaaga gtgtgatcat      720

tggagtgatt gaaggtggag atgtgatgga agagaggctg aggtcagcac gagagacagc      780

caagcggcct gtgggtggct tccttctgga tggttttcaa ggaaatccaa caaccctgga      840

ggctagacta cgcttgctgt catcagtcac tgcagagctg ccggaggaca agccaaggct      900

catatctggt gttagtcggc cagatgaggt gctcgagtgt attgaaagag gagtggactt      960

atttgagagt tttttccctt atcaagtaac agagcgggga tgtgccctga ctttcagttt     1020

tgattaccag ccgaatcctg aagagacact actacaacaa aatggaacac aagaagaaat     1080

aaaatgtatg gatcaaataa agaaaattga aacaactggt tgcaaccaag aaataacatc     1140

atttgaaatt aatctgaagg aaaaaaagta ccaggaggac tttaacccgc tggtgagagg     1200

atgttcctgt tactgctgta agaatcacac tcgggcatac atccaccatc tgctggtgac     1260

caatgagctg ctggccggag tcctgcttat gatgcacaac tttgaacact actttgggtt     1320

tttccattac atccgggaag cactaaaaag tgacaaactg gcacagttga aagagctcat     1380

ccacaggcaa gcatcttgag atcttgcaaa tacaagtctc actcttcaca ctgagcctgt     1440

accactgttg taacatggga agacgtgaag aagaaataat ctgagcttta attatttata     1500

tttggatata aggtctgctt aaataaagaa tctttgtacc aaactgccca catgagggtg     1560

aagagatttc ctcaaaagac ttaaatgacc tggattgatc agagagaatt gaactgtgac     1620

ctttaagact tctagactaa ttcttttagt tgatagagat tcatttagtc aaagacaaaa     1680

gctttaactg tgagggcaca gccttgaagt gggagtgatg agattctgag ggacccatga     1740

attggattga ggcttgaggg gaaatggtgt gagacgaatg ggctctggac atatgcctgt     1800

tgatttgaga agaaatctgg ctggtttgag ggtttccttt agttcaccct catactctca     1860

ggagactctt ctggatactt ttgtcttcca ccctgccctg gcagtgcagc caatcagaaa     1920

tggctcttgt gacttaactg ggcttggata tccctggaat gtggggcttg aacattgctc     1980

ctgtgatgat catctgtccc aggtcacact ccttcatttg accacatggc ctatttgcaa     2040

cttcttttta gagccaatgt aattgcctgt taggagccag aagtttgccc agctgctttc     2100

ttctggttgt acagatccat tgtggtctgc cttccaggct cattaatagt ctaactacgt     2160

aataactgaa gacctatctc ttgtgaagat tcattctcaa tgtgttcact tggacagagc     2220

cctgcctggc ctaacgatta gagggttagt ctccatcctg ctcagatatg actcctgggc     2280

aattcactta acttctccat ggctgcttcc tgctgaataa atagggacag gcataatgga     2340

taggaatgaa tgaactttta agatactgtc tagctctaaa attggaagaa caaaaagttt     2400

tagattagag tcatagcctt aatagcccta gttgtcatcc tgggagacag gcaacagtag     2460

agatatttga gagcctaaag agaggtttgg cctgtgggtt tttaagtggt tattgaattg     2520

gtatcaggag atcctgaggc tggtagggga aggtaattct ttctaagtta cctctgtatt     2580

tttcaagttt tctataagga atacacatac acccacatgc acacaccata gtttttatac     2640

aaacagcaat aacaaaacca aaaagatgcc cctttttttg tagggataag aaatacattt     2700

gttttatact tctatgctat attttgctat tcaaaattta gtgggcatta cttaacattg     2760

tttctaatta ttttgtggct gctgtatgtt ttatgtgttg ggagcccatt gtattaggcc     2820

gttcttggat tgctataaag aaatacctga gactgggtaa tttggttttt tggttttttg     2880

gggttttttt tgagacggag ccttgctctg tcgcccaggc tggagtgcag tggcgcgatc     2940

tcggctctat gcaacctcca cctcctgggt tcatgccatt ctcctgcctc agcctcccga     3000

gtagctggga ctacaggcgc ccgccaccat gcctggctaa ttttttatat ttttagtaga     3060

gatggggttt caccgtatga gccaggatgg tctcgatctc ctgacctcat gatccacaag     3120

actgggtaat ctgtaaagaa aagaggttta attggctcat ggctctgcag gctttacagg     3180

aagcatggta ctggcatctg cttggtttct ggggaggcct ccggaagctt atagtcatga     3240

cagaaggtga agggggagca ggcacatcac atgacaaaag caggaacaag actcagagca     3300

agaagtcact tatcaccaag gggatggccc aggccattca tgagggatcc acctttgtgc     3360

tccaaacacc tcccaccagg ccccacctcc agtattgggg attacatttc aacttgaggt     3420

ttgggcggga acaaatagtc aaattatatt acccatctac atggttttct ttttcttagt     3480

atgggagtgt ccatgaataa attcatgggc atcctcataa ctcttccatg aatggcaagg     3540

ggtacttatg gaaaacagtt ttccaaagat ctgattgttt tgaaatgtgt tagattggac     3600

ttgttcaaat gttcatattt ttgttctatg ctaaatgcat cgttagggga gtagtggtaa     3660

atattccaga atccatatga aattcatgag tttatttatg tctaaaacac tgaaaactgt     3720

gtccaatatc gttcagtttc ctgggtcttt ttcttattag cacatttgag aaaaatattc     3780

ctttccttta ttgtagtaaa tctattaaag gcaatagcca ataaaacatt tttaatttta     3840

aaaa                                                                  3844


<210> 3772
<211> 474
<212> DNA
<213> Homo sapiens

<400> 3772
tccggcgccc gcgaggcccc gagtcctcct ccggagggcg gctgcgggcc tgccctcttc       60

tcctaaccag acacgtctgc ctctatgaac cagcgcagcc atctgggcac cacctacctg      120

gacacggcca aaggcgcggt agagaccttc atgaagctcc gtgcccggga ccctgccagc      180

agaggagaca ggtatatgct ggtcactttc gaagagccgc cctatgctat caaggctgga      240

tggaaagaaa accatgcaac gtttatgaat gaattgaaaa accttcaggc tgaaggactt      300

acgactcttg gccaatccct aaggacagct tttgatttat taaatttaaa tagattagta      360

actggcatag acaactatgg gcagggaaga aacccttttt tcttggagcc agcaataatt      420

atcacaatta ctgatgggag caagttgact accaccagtg gagtccagga tgag            474


<210> 3773
<211> 503
<212> DNA
<213> Homo sapiens

<400> 3773
caggtagtgc ccgctggagc tcgcgcgctc atccggcacc actccagggc tccaggctcc       60

tcgggcttcc ggagtcgaga cgtgaagatg aatccggcct cggcgccccc tccgctcccg      120

ccgcctgggc agcaagtgat ccacgtcacg caggacctag acacagacct cgaagccctc      180

ttcaactctg tcatgaatcc gaagcctagc tcgtggcgga agaagatcct gccggagtct      240

ttctttaagg agcctgattc gggctcgcac tcgcgccagt ccagcaccga ctcgtcgggc      300

ggccacccgg ggcctcgact ggctgggggt gcccagcatg tccgctcgca ctcgtcgccc      360

gcgtccctgc agctgggcac cggcgcgggt gctgcgggta gccccgcgca gcagcacgcg      420

cacctccgcc agcagtccta cgacgtgacc gacgagctgc cactgccccc gggctgggag      480

atgaccttca cggccactgg cca                                              503


<210> 3774
<211> 2445
<212> DNA
<213> Homo sapiens

<400> 3774
ctctttgagg ctttctgatg cctagagtga gctcaactca aaggtttcca gcctcacact       60

cgcctcacat tcccccacag tcacattgcg ctctgtgatt ctgaggaata cagtgtgcca      120

gcatccgatc cagtctcctt tcacctgcag gtgttccaga aacttcaaaa tgcgtctgga      180

agaactgaaa agattgcaga atcctctaga acaagttaat gatggaaaat attcatttga      240

aaatcaccag ctggccatgg atgcagagaa taatattgaa aagtatcccc tcaatctaca      300

gcccttggaa tcaaaggtga aaatcattca gcgagcatgg cgagagtacc tgcagcggca      360

ggagcccctg gggaagagga gcccgtcccc accctctgtc tcctcagaga agctgagcag      420

ctctgtcagc atgaacacct tctccgacag cagcacaccc gattaccgag aggatgggat      480

ggatctaggc agtgacgccg gcagcagcag cagcagcagc cgcgccagtt cacagtccaa      540

ctccaccaaa gtgacccctt gctccgagtg caaatcttca tcgtcgccgg ggggcagcct      600

ggacttggtg tctgccctgg aggactatga ggagcccttc ccggtctacc agaagaaggt      660

gattgatgag tgggcgccgg aggaggacgg ggaggaggag gaagaggagg acgagcgcga      720

ccagcgaggg taccgggatg accgctctcc ggcccgggaa ccgggggacg taagcgccag      780

gacccgcagc ggcggcggcg ggggcaggag cgccaccacc gccatgccgc ccccggtgcc      840

caacggcaac ctccaccagc acgaccccca ggacctcagg cacaatggca acgtggtggt      900

ggctggccgg ccgagctgtt cccggggccc ccgccgggcg atccaaaagc cccagccggc      960

tgggggccgg cgcagtggcc gcggcccggc ggctgggggg ctctgccttc agcccccaga     1020

cggcgggacg tgcgtccccg aagagccccc ggtgccacct atggattggg aggcgctgga     1080

gaagcatctg gccgggctgc agttccggga gcaggaggta cggaaccagg gccaggcgag     1140

gaccaactcc acctccgcac agaaaaatga gagagagtct atcagacaga agttggcact     1200

tggaagcttc tttgatgatg gcccaggaat ttataccagc tgtagcaaaa gtgggaagcc     1260

aagcctttcc tcccgactgc agagtgggat gaacttgcag atatgctttg tcaacgacag     1320

tggcagtgat aaggacagtg atgctgatga cagtaagact gaaaccagct tggacacccc     1380

cttgtctccc atgagcaaac agagttcttc ctattctgat agagacacta ctgaagagga     1440

gtctgaatcc ttggatgaca tggacttcct tacaaggcaa aagaaattgc aagctgaagc     1500

caaaatggcc cttgccatgg ccaaaccaat ggccaaaatg caagtagaag tggagaaaca     1560

gaacaggaaa aagtctcccg tcgctgatct tctgccacac atgcctcata taagtgaatg     1620

cttgatgaaa agaagtttaa aacccaccga cctgagagac atgactattg ggcagctaca     1680

agtgatagtc aatgatctcc attcccagat agaaagcttg aatgaagagt tggtccagct     1740

gcttctcatc cgagatgagc tgcacacaga gcaggatgcc atgctggtgg acattgaaga     1800

cttgaccaga catgctgaaa gtcagcagaa gcacatggca gagaaaatgc ctgcaaagtg     1860

aaaagaagcc attcaaccag agaacaagct agaatttatt ttgcttctgt ggttgtaaaa     1920

atgctgttgc taaaggtggc gcagaaacaa atatcagtgt tagtcattga taatgtctga     1980

agcttaatgt ccagtgattg gcctttgctt cttaatttat tttaattttt tacttgtgcc     2040

acttaatatc aggcatttta ataaaatatt gttacaaaaa atgtacagta ctgacaccac     2100

cacaaatcat ggttaataaa agagagtagt tttaacttta tttttatttg tttagagatt     2160

ttaagttgga acagtatttt cccattgact acttttcatt cttcactgta gttttaaaga     2220

agaactgtaa atgacggtgc tatacaagtc aaaaaataca tgcctgcctc gtagtgaagt     2280

tgtagctctc cgtaatatgt atattttact cagttttcaa cattttgtga atgttgacta     2340

cctgaagttc ctttttagat gtgctattaa cattctgttg gattcagagg gttccttgaa     2400

agttttatgt ataaatatgt aaaataaaaa ttaaaacttt gtttc                     2445


<210> 3775
<211> 524
<212> DNA
<213> Homo sapiens

<400> 3775
attgttcttt ggtattgtgc cttacgtgag ctggggacta actctgtatc cttaaggagg       60

catcacttga ttagagttgc ccaaaagaat gtgggttatt atcctaaagg tctgtgttgc      120

catcctgaaa cagtcagaaa tcagttttta tttcacttag gtggttccgg ggagaagcct      180

ttccaggacc catgtgtagg cacaactgtt ttccctgatc aggatacttg cggcactcaa      240

cagaggaaag aaattcctaa gggaacactg ctcagaaagt actgcagcat gtcttcaaat      300

gcctgaggat caagttggaa aactagaagc aacagaaaac acaataagcg caatggcggc      360

ggccgcggcg gagcagcaac agttctacct gctcctggga aacctgctca gccccgacaa      420

tgtggtccgg aaacaggcag aggaaaccta tgagaatatc ccaggccagt caaagatcac      480

attcctctta caagccatca gaaatacaac agctgctgaa gagg                       524


<210> 3776
<211> 3812
<212> DNA
<213> Homo sapiens

<400> 3776
agtgcccccc gcgccccgct ccggcagctc cacgctcgcg cccgccatgc cggagcagtt       60

cagcgtcgcc gagttcctgg ccgtcaccgc ggaggacctc agctccccgg ctggggccgc      120

cgccttcgcc gccaagatgc cccggtaccg aggggcggcg ctggcgcggg aggagatctt      180

ggaaggagac caagccatcc tgcagagaat aaagaaggct gtgcgggcaa tccatagctc      240

cggccttggc catgtggaga atgaagagca gtaccgagag gccgtggaat ccttaggcaa      300

cagccacctg tcccagaaca gccatgagct gtccacaggc ttcctaaact tggccgtgtt      360

cacccgcgag gttgctgcgc tcttcaagaa cctgattcag aacttgaaca acattgtctc      420

tttccccctg gacagtctga tgaaggggca gctgagggac ggtcgacagg attccaaaaa      480

acagctggag aaggcatgga aggactatga agccaaaatg gccaagctgg agaaggagcg      540

cgatcgggcc agggtgacag gagggatccc tggggaggtg gcccaggaca tgcagagaga      600

gcggcgcatc ttccagctgc acatgtgtga gtatctgctc aaagccgggg agagccagat      660

gaagcaaggt cctgacttcc ttcagagcct catcaagttc ttccacgccc agcacaactt      720

tttccaagat ggctggaagg ctgcccagag cctgttcccc ttcatcgaga agctggcggc      780

ctcagtacat gcactccatc aggcccagga ggacgagcta cagaagctga cccagctccg      840

ggactccctc cgagggacac tgcagcttga gagcagagag gaacacctga gccggaagaa      900

ctcaggatgt ggctatagca tccaccagca ccaaggcaac aagcagtttg ggacggagaa      960

agtgggcttt ctatacaaga aaagtgacgg aattcgaaga gtctggcaga aaaggaagtg     1020

tggagtcaag tatggctgcc tgaccatctc acacagcacg ataaaccggc ccccggtgaa     1080

gctgaccctg ctgacgtgcc aagtgaggcc aaaccctgag gagaaaaagt gcttcgacct     1140

ggtgacccac aaccggacgt accactttca ggcagaggac gagcacgagt gtgaggcgtg     1200

ggtgtcagtg ttgcagaaca gcaaggacga agccctgagc agcgccttcc tcggggagcc     1260

cagcgctggc ccggggtcct gggggtccgc cggccatgat ggggagccgc acgacctcac     1320

aaagctgctc atcgcggagg tgaagagcag gcctgggaat agccagtgct gcgactgcgg     1380

ggctgcagac cccacgtggc tcagcaccaa cctgggcgtg ctcacctgca tccagtgctc     1440

gggcgtccac cgcgaactgg gcgtgcgctt ttcgcgcatg cagtcactca ccttggacct     1500

gctgggcccc tccgagttgt tgctggcctt gaacatggga aacacgagct tcaatgaggt     1560

catggaggcc cagctaccct cacacggcgg ccctaaaccc tcagctgaga gtgacatggg     1620

cacccgcagg gactacatta tggccaagta tgtggagcat aggtttgcac gccggtgcac     1680

acctgagcct cagcgactct ggacagccat ttgcaacagg gacctcctgt cggtactgga     1740

ggcctttgcc aatgggcagg actttggaca gccgctgcca gggcctgatg cacaggcacc     1800

tgaagaactc gtcttgcatt tggctgtcaa agtcgccaac caggcttccc tgcctctggt     1860

ggatttcatc atccagaacg gtggtcacct ggatgccaag gctgctgacg ggaacacggc     1920

tctgcactac gcagcactct acaaccagcc cgactgcctc aagctgctgc tgaaggggag     1980

agctttggtt ggcacagtaa atgaagcagg cgagacagct ctggacatag ccaggaagaa     2040

gcaccacaag gagtgtgagg agctgctgga gcaggcccag gcggggacct ttgccttccc     2100

tctacatgtg gactactcct gggtaatttc cacagagcct ggctctgaca gtgaggagga     2160

tgaggaagag aagcgctgct tgctgaagct cccggcccag gctcactggg ccagtgggag     2220

gctggacatc agcaacaaga cctatgagac tgtcgccagc ctgggagcag ccacccctca     2280

gggcgagagt gaggactgtc ccccgccctt gccagtcaaa aactcttctc ggactttggt     2340

ccaagggtgt gcaagacatg ccagtggaga tcgttctgaa gtctccagcc tgagttcaga     2400

ggcccctgag acccctgaga gcctgggcag tccagcctcc tcctccagtc tgatgagccc     2460

cttggaacct ggggatccca gccaagcccc acccaactct gaagagggcc tccgagagcc     2520

cccaggcacc tccagaccca gcctgacatc cgggaccacc ccttcggaga tgtacctccc     2580

cgtcagattc agctccgaga gcactcgctc ctatcggcgg ggggcgcgga gccctgaaga     2640

tggtccctca gccaggcagc ctctgcccag aaggaacgtg ccggttggca tcactgaagg     2700

agatggctca aggactggga gtctcccagc aagttctgtg caacttttgc aagactagct     2760

ccttgctggc ccccacatgc cccatgctag gccccaatgt tcagagctgg gacttgagct     2820

cacaaaactg gggagctgag acatttgttc tcttggatct cactctctct gtcccttgtg     2880

cctctgtagc tggccttctt cctgccacag gccatgcctc taccaaggac acatggcctt     2940

tccctgttag gactgatggc ggttctttcc tatctcatta cccgctaggg gcctgggagc     3000

cctgtggctg gatctgagtg ctcctgagct ggcttcagct gcagaactct cagtccctca     3060

tcagatcgag actctatttc ccccgtcagt ctgggggctt cacaagggca ggagagccct     3120

ccatcactga cttccagatc agggaccctg ccaagtaggg actgtcttct cagccagcca     3180

tttattagtc taatattcct tcactaaatt ccaactctat gtctggacct gtgttaggca     3240

cttcagatac cacacgagta agacaagggc cctgcagggg tggtcctttg gtggaaagct     3300

ggtcttaagg gttgggcttg ggaataggca gggtcagatt ccagggcatg gctctggact     3360

cagctggttt atacctatat gaccattaca attgtctaca gatcacatcc attctggctg     3420

gtcaacatgc atgctgtact ggctgttaaa taaaaatatt ctgaatgtca ctccttttga     3480

gggacagcac agccttccct aggcattctc ctatattccc caatgagaaa gcagatacac     3540

ctaagccatc atcaaccact aacatctcaa cttgccagtt gctgggtgct gggccctggc     3600

aggaatgggc caagccaagc aggggagact agagagcacc aatggccaac acagctgcct     3660

ggctggggag gctgtgctgt ttcccctgga gacctgactg gtctgtggtt cccacaggaa     3720

cagggttgtc ttttgagccc ccagtgtctg gtttcattca tctcagactt gttatttcac     3780

tcatctctaa taaaggattg gggggtcagt tt                                   3812


<210> 3777
<211> 583
<212> DNA
<213> Homo sapiens

<400> 3777
ttttaggcgc cattttcgag tgaaggaccc ggagccgaaa caccggtagg agcggggagc       60

gaccatgccc cgtaaaggca cccagccctc cactgcccgg cgcagagagg aagggccgcc      120

gccgccgtcc cctgacggcg ccagcagcga cgcggagcct gagccgccgt ccggccgcac      180

ggagagccca gccaccgccg cagagactgc aagtgaggaa cttgataata gaagtttaga      240

agagattttg aacagcattc ctcctccccc gcctccagca atgaccaatg aagctggagc      300

tcctcggctt atgataactc atattgtaaa ccagaacttc aaatcctatg ctggggagaa      360

aattctggga cctttccata agcgcttttc ctgtattatc gggccaaatg gcagtggcaa      420

atccaatgtt attgattcta tgctttttgt gtttggctat cgagcacaaa aaataagatc      480

taaaaaactc tcagtattaa tacataattc tgatgaacac aaggacattc agagttgtac      540

agtagaagtt cattttcaaa agataattga taaggaaggg gat                        583


<210> 3778
<211> 7917
<212> DNA
<213> Homo sapiens

<400> 3778
gaagcttgaa gacattatgc taagtgaaat aagccagtca caaaagaaca aatattgtat       60

tatttcagtt atataaagtt tctagactag tcaaattcat agaaactagg atgatagttg      120

ctagggtcag ggagaagagg ggatggaaag gtattgttta atggatgcag agtttcagtt      180

tgagaagatg aataaaagaa aaaaatgaca ttaaattttg tcaagatagc atattgaaaa      240

tataatagaa aaatatttgt ttatctgcta taatatatta tgtcataggt gttatcttca      300

ggaaggcaca ctggacctgc taaattaaca aatggaaaga aagcgtaagt acttgaagac      360

gtttacaact tcagatttca aggaattttt caggtctttg ggctggatga catgtcgtct      420

accccagaaa attaggtagg cctctaccat cacaagctct gaggaacaat ttttcatgtc      480

tacccatgtt aatcatttta gtatttaaca gtctttctga tcttcagaat gtgtttataa      540

attcatcttg tacatggttg gacaagcttt cttgtctttg ctggaaagaa aatgactact      600

tactaatata ttttgggaaa aatatttgta agaatattaa taagcttgtt ttccaggacc      660

tatttaagaa aaataccacg ttttaatgca gattctggct attccatcca ttctgattca      720

gaaagtcagg taagattgaa tagatacaat acacactatt ttaattagtt ttcaaatagt      780

agctaaaaag taggaataaa atgcaaagta ttaattgctc taaggaagta tgaagtctgt      840

tgctttaaaa catcttttct accaataata gtttgtaaat aaacaaattt taaaactaca      900

taatttatat tttttcctac actaacagtc atatacaaat gtattctaaa tgactttatt      960

tcttacaggc tgaaactgta cacgggcttg atggttgtgc ttctttgctg agggacattt     1020

tgagaaatga agattcaggt tttttttttt taattctttg ctgatcacct tatctcaagt     1080

cattattttg atgtaacaaa tttttgtttt attaataggt tcagaaacag catatttaga     1140

aaacagatct aattctagac ctttagaaag caaaagatac ggatcaaaaa agaaaagaca     1200

tgaaaaacat actattcctt tggtagtcca gaaagaaaca tgtaagcctt ttttctctta     1260

gttatttaaa gataatcctt aattgtgggt attttgatca attatcagga ttatacagtt     1320

gattttcatt ttaataatca gtattagtta ggtttatgtg tgcttatgcc tttctgtatt     1380

cagcttctaa tcactgagta gtccactttg cttgctatca ttttctcaag aagaaaaata     1440

gaaaaagaga ctgtcagggt tttgtaggag aaaaagttca aactcagaat gacatttggg     1500

aggtatatag agtgatctta gtttcccctg ccacttgttt tcatagataa tcataaattg     1560

gttgtatttc aagtgtatac ttctagtagt tgctttaaaa ttattatatt tatatatata     1620

tatatcctaa gttggtcaag ctgaacttgt caagctacac agttaggata catggtacat     1680

aggaaggtaa aatcggatga ataaggaaag gctgctgctg attggtggtg agtatagcca     1740

agggtacttt acaccctcac ggctaacttt tcctagttta gaacaagaaa gttttgatta     1800

tgttgtccct tggaggccta gaaaacaaga tagcccaaaa tgaagatgaa aaagtccaca     1860

gtgggaattc agatggacta gaattagact agccagttct atagttcagg tgggccagaa     1920

atgtcagcac tgtagtacgt gcttagattc agcttgggca aggaatgaag tttagaaagt     1980

catataaagc agtagcccta taaagagatc aggatttaag caaggaggct gagaaagtgt     2040

cagtagagca ttcatgggac tagaggttga tgtttcagat agtcccaagg tagagaacta     2100

aggcaaggga aacctaactc atcttggagg ccagtaatga tagctttata ttatcttgac     2160

ctgtgctatt caagatggta gccactggcc acatgtggct attcagcact tgaaatgtga     2220

ctagtacaac caaggaattg aattttaatg ttatttaatt taatttaatt taaaattaaa     2280

ttagaaaact gataattgat ccagttatta taaaactttt aagtatgttt ggaataactt     2340

gggcatgtga acctaccttt tcaagtgtaa attttattaa atctaaatat agaccaagta     2400

tttctgatga gaatttagca tctagattgt gctttgtgta aaatatatgc tagatttaga     2460

agatttaata caaaatttca gttatttata ttatacactg aaatgttaat attttggata     2520

tattgattta aatattatga aaagtaattt tacctatttt atatggttac tggaaatttc     2580

aagttacata tatggtttgt attatatttc tattggacag cattggtcta agctcaatac     2640

actacagcca gttttataag taatgtttag ttattttatt gtgtaaataa gattttatta     2700

gaatgcagcc aagctaattt attaatgtgt ttttattagc tgtttttgtg ctgcagtgtc     2760

agagttgagt agttttgaca gagatcatct ggcctgctaa acctaaaata tttatttgac     2820

ctttgaagaa agagtgctaa accctggcct taactcttta aagcagaggc ctttttattg     2880

gggcccaact gagaaagaaa ggagcggtag cacctgttcc tccagtctcc tactttttgt     2940

ctgtaggcag gttatttctt atccagggca cctttcctca aggaactatt atttgcaata     3000

tatgtgactg gcagtgggtg tcatggtatc aacttactgg atcctgactt aactgcctct     3060

gtcggtcaga gttccaacaa gaaacagatg gcaacactca aattgaggta attttaggag     3120

ggtttattta caaagggact cataaaggta tgaatagggt ataggaaaac cacaggtttt     3180

gcctactagg tcatgcgagc ctagtgctag cagcagagca gcagagctgt tatcatctct     3240

aggccataag ggattaggag agagagaggt tactggatct agaaagagat actgtttata     3300

gaatacgcta ccttgagaag agcagtgagc ttcattgaaa tgacgaaggc agcccaaggt     3360

ggccttatag aaagggagca ggaataagtg tatatcctga cttcatgctt cttcctttcc     3420

ttgatatgcc aagactccca ttggattgaa cccaactgaa gccctactga tgtatatcag     3480

gtctgggatt tgactcttac aagctagtaa gttagtctta ctgtgtcatg gatgctagca     3540

gaagacaaga ctgctgggtc agagacaaag gactttatta ctcacagcac aggaagcagt     3600

atgtgcatca gcatattgtg ttggttctca ttcaccctag ttcccattgg ggtgatatgg     3660

tggacccata tggatgctgc acatgcctta ggtttaggtt gcagctgagg aacactgagc     3720

ttggggaatc cgtcactttg gtagtaagca gtaatcaagc ctgtgcttgt cccagaggga     3780

aacattacct catccttcaa ggttgctcac tgcagacaca accctgagaa gcggcccagg     3840

taaggagttt aggtcaaagc cttgcttttt tggtatatac agcaagacat attgaaggac     3900

tgtctttttg cagcccatat ggatcagcat tccagggaga ccagggtgaa gaccagtaga     3960

ggtgggtttg gattggcaga tggaagattc tggcattctg ggtccatagc gttaaattct     4020

tatttggatt acagccgaat cagcagttct ggcctgtgat cagggtgcaa tattcttatt     4080

gttctttctc ccatattttc ttaatcagaa ggaaggacct acttccacag gacaatcttc     4140

tttagggttg caatattaga aattagtttc tagttgtgtg tgtgtgtggt tggcagctgt     4200

taaccaataa tacaagattt tgctttgtta ccacaatgct caaaaataca caaaatccaa     4260

gctcataact tgttctcttt accgtctcca agtgaagtaa tcataaagaa ctttaagcga     4320

tctattacag catgttaact agtatccatg tattatttta cttttaacac acattatctt     4380

gctattttgt gttaactgtc ttctggggag tggcctcctt atgtactttc tatctgggat     4440

gatatgatca ttgaatgcct acctgatcac tgaatgccta tggagtcagc atcttcagat     4500

aataagaaac agatacctaa tgaagcttct gctagaagtg aaagagacac atcagaccta     4560

gagcaaaact ggtcattgca agatcattat agaatgtatt cacccataat ataccaagcc     4620

ctctgtgagc acgtgcagac tcagatgtca ctgatgaatg acttgacttc aaagaacatc     4680

cctaatggaa ttcctgctgt accatgccat gctccctctc attctgaatc tcaggcaact     4740

cctcattcta gttatggctt atgtacctcc accccagtct ggtcacttca gcggccaccc     4800

tgccctccaa aggttcattc tgaagttcaa actgatggca acagtcagtt tgcatcacaa     4860

ggtaaaacag tttctgcaac ctgtactgat gttctacgga attcatttaa taccagtcct     4920

ggagttccat gtagcctgcc caaaactgac atatcagcta ttccaacatt gcagcaactg     4980

ggccttgtta atggaattct gccacaacaa ggaattcata aggaaacaga cctactaaaa     5040

tgtattcaaa catatttgtc tctttttcga tctcatggaa aagaaacgca tctggacagt     5100

cagacacacc gaagccctac tcagtcacaa ccagctttct tggccactaa tgaagaaaaa     5160

tgtgccagag agcaaattag agaggccaca agtgaaagaa aggatttaaa catacatgtg     5220

cgagatacaa aaacagtgaa ggatgtacag aaggcaaaaa atgtgaacaa gacagctgaa     5280

aaagttagaa ttataaaata tttgttggga gagctcaagg ccctggtagc agaacaagag     5340

gattcagaaa ttcagaggtt gattacagaa atggaggcat gtatatctgt acttccaaca     5400

gtaagtggaa acacagatat tcaagttgag atagcactgg ccatgcaacc attaagaagt     5460

gagaatgctc agttacgaag gcagttgaga attttgaacc agcaactcag agaacaacag     5520

aaaactcaaa aaccatctgg tgctgtggat tgcaaccttg aattgttttc tcttcagtca     5580

ttgaatatgt cactgcaaaa tcaattggag gagtcactaa agagccagga attactgcag     5640

agtaaaaatg aagagctgtt aaaagtgatt gaaaatcaga aagatgaaaa caaaaaattt     5700

agtagtatat ttaaagacaa agatcaaact atacttgaaa ataaacagca atatgatatt     5760

gagataacaa gaataaaaat tgaattggag gaagccctag tcaatgtgaa aagctcccag     5820

tttaagttag aaactgctga aaaggaaaac cagatattgg ggataacatt acgtcagcgt     5880

gatgctgagg tgactcgact aagagaatta accagaactt tacagactag catggcaaag     5940

cttctctccg atcttagtgt ggacagtgct cgctgcaagc ctgggaataa ccttaccaaa     6000

tcactcttga acattcatga taaacaactt caacatgacc cagctcctgc tcacacttcc     6060

ataatgagct atctaaataa gttagaaaca aattacagtt ttacacattc agagccactt     6120

tctacaatta aaaatgagga aaccatagag ccagacaaaa cctatgaaaa tgttctgtcc     6180

tccagaggcc ctcaaaatag taacactagg ggcatggagg aagcatctgc acctggaatt     6240

atttctgccc tttcaaaaca ggattctgat gaagggagtg aaactatggc tttaatagaa     6300

gatgagcata atttggataa tacaatttac attccttttg ctagaagcac tcctgaaaag     6360

aaatcaccac tttctaagag actatcccct cagccacaaa taagagcagc tacaacacag     6420

ctagtcagca acagcggact tgctgtctct ggaaaagaaa ataaactgtg tacacctgta     6480

atctgttcct cttcaacaaa ggaagcagaa gatgcacctg aaaaactttc cagagcatct     6540

gatatgaagg acacacagct cctcaagaaa ataaaggaag caattggtaa gatccctgct     6600

gccaccaagg agccagagga acaaactgca tgtcatggcc catcaggttg tcttagcaac     6660

agccttcaag tgaaaggcaa tactgtctgt gatggtagtg ttttcacttc tgacttgatg     6720

tctgactgga gcatctcttc gttttcaacg ttcacttctc gtgatgaaca agacttcaga     6780

aatggccttg cggcattaga tgccaacata gctagactcc agaagtcttt aaggactggt     6840

cttctggaga aatgaattca gaagaaaact catcaggtgc ttctttttaa aactagaact     6900

tggctatatt gaatgtgtat ttttctttag tgaaatgatg ttttatgtta ttatgtgtga     6960

agtaatatat tgtacaagta ataaatgtat tgttgagata tattgacact gaggagctta     7020

taaaaacaag tcatcttaag ttcacaattg ctacaagaag aaagttgtgg ataactagga     7080

aattattgta agtaatgttt tatttcagta cttagcaatt agagttcttt tattaagatg     7140

tatctgctgg attaagggta caggttgaaa tagttctgtg gctgtcctaa gaaataatgg     7200

gaaaagaatc tctggatgta agtttttctg ttgaaactag agggtttttt ttttctgttt     7260

acatatactt ttttttaata gcaatgtgtt tttattaaac atgctgtgtg ccacaggcca     7320

gtgttgttgg tgaaatatat aaacatttat ttaaagagaa aagttaccag tatctacacc     7380

tcttaaaaaa cattgattgg tctaaaaaat atatagataa catcctaagt taacatatgg     7440

cttcttaaaa cttgggcact tttatttgtt tttatcccaa attcatgttt taaggccttt     7500

aaagaatagt cagactgata aagaagtgct aacagataag ctatagttgg ggaaatttgt     7560

gggttttttt taaataagaa atgtttattt ttgtccttat atttaaacat gatggaattt     7620

gtaaatcttg gcattgattg taattctgcc tttttggaag aattttttct cccagcatgt     7680

tagctgagaa tattctctat tttataaata atatgaagta ggttggtctc tctgcttctc     7740

tataccagga cttcttagct cagtatcatc tcccttcatg taagcagcac gttttaactc     7800

ttaggaagct gaatgttgtg ttatcactaa tactttgtac aggtcacctg cctactctaa     7860

ttgtccttag tacttggaca ggctttatca ttaaagagtg ttctcctaat cccagaa        7917


<210> 3779
<211> 772
<212> DNA
<213> Homo sapiens

<400> 3779
ggaagctctg agtcactgaa tagcaaagaa aaatatgaaa gcaagaggaa ttgctttcac       60

atctagaaaa tgttgcaaga taatctgaaa tcttctggtg ctggtgaatg catgaagagg      120

ttcacagtat cttttaaagt acttctgaaa agataaggag tttaaaaggt gggtgtgtac      180

actggcactg agctgcagta ggatttttcc ttggatagtc tggtctggag ctgggacagc      240

agctgctgct gtggaaaggc cagctggcaa gatgatggaa gaaatctcca ttatggtagc      300

ctatgacgcc catgttttca gccagctgca cgatgaagac ttcctcacta gtctggtggc      360

catcagcaag cccaggtcta tggtaccaac caagaagctg aagaaatatg agaaagaata      420

tcagacaatg cgagagagtc agctgcaaca ggaagaccca atggatagat acaagtttgt      480

atatttgtag gtaactccag ctgttgcatt tatactggga atcttcataa gaagctgaga      540

gaaagagagg ggaaaaagaa agtggctttc tactttcaaa aatgaaacaa aaaggaaaaa      600

tggcaaagta ctgttttagc tgtgcatgtc atatccacaa agacttttag caggtgaact      660

gttccaagac tgacacaagg atgtttcaaa cttgcctctg tctgtagaaa atgttaaaaa      720

taccaactca cttggaagga aaaataaaaa tcacaaaggt atattgagca ca              772


<210> 3780
<211> 880
<212> DNA
<213> Homo sapiens

<400> 3780
gagattttgg gaatccactg agaaaattca agttggtgtt cttgggggag cagagcgtgc       60

cctgggttcc ctgactgctc tggccttcca tgggtgttct gcgggactgc tggcagccct      120

tccggactcc tccctctctg ctacctgctc aggttggatg tggcatatga ccagaaactg      180

gccattggtc gggaagacgt ctctgattac gaggttcatg tacgacagct tcgacaacac      240

ataccaggca accattggga ttgacttctt gtcaaaaacc atgtacttgg aggaccgcac      300

ggtgcgactg cagctctggg acacagctgg tcaggagagg ttccgcagcc tgatccccag      360

ctacatccgg gactccacgg tggctgtggt ggtgtacgac atcacaaatc tcaactcctt      420

ccaacagacc tctaagtgga tcgacgacgt caggacagag aggggcagtg atgttatcat      480

catgctggtg ggcaacaaga cggacctggc tgataagagg cagataacca tcgaggaggg      540

ggagcagcgc gccaaagaac tgagcgtcat gttcattgag accagtgcga agactggcta      600

caacgtgaag cagctttttc gacgtgtggc gtcggctcta cccggaatgg agaatgtcca      660

ggagaaaagc aaagaaggga tgatcgacat caagctggac aaaccccagg agcccccggc      720

cagcgagggc ggctgctcct gctaatgcag agccgacctg tggcttccca tgacactcct      780

tgcttgttgt gttgcttcct attggctagc ttcctaaggg gggagggaac cgagttatca      840

agatgggagg atttttcttt tctctctgtc tttaggagta                            880


<210> 3781
<211> 2053
<212> DNA
<213> Homo sapiens

<400> 3781
acaatactta agtcctggca agtcataagt ggggaaaatg tctctcccaa gattccaaag       60

agtaaacttt gggccatatg ataattacat tccagtcagt gaattaagca aaaaatcatg      120

gaatcagcaa cactttgccc tgttatttcc caaaccacaa cggccaggaa ccaaaaggag      180

atcaaaacct tctcaaatac gggacaacac ggtttctata attgatgaag aacaattaag      240

aggagatcgt agacaaccat tatggatgta ccgttcttta atgagaattt ctgagagacc      300

atctgtttat ttagctgcca ggaggcagcc tctcaaacca actcgtactg tcgaggtgga      360

ttctaaagca gcagaaattg gtaagaaagg tgaagacaag acaacacaga aggacacaac      420

agattcggaa tcagaattaa aacaaggaaa aaaagattca aagaaaggca aggatataga      480

gaaaggaaaa gaagaaaagc tagatgcaaa gaaagatagc aaaaaaggta aaaaggatgc      540

agagaagggc aaagactcag caacagaatc tgaagatgaa aaaggaggtg caaagaaaga      600

taacaaaaaa gataaaaagg attcaaacaa aggcaaagac tcggcaacag aatctgaagg      660

tgaaaaagga ggtacagaga aagatagcaa aaaaggtaaa aaggattcaa agaagggcaa      720

ggattcagcc atagaattac aagctgtaaa agcagatgaa aagaaggatg aggatggaaa      780

aaaagatgca aacaaaggtg atgaatcgaa ggatgccaag aaagatgcaa aggagattaa      840

aaaaggtaag aaagataaga agaagcccag tagtacagac agtgactcaa aggatgatgt      900

caagaaagag tctaagaagg acgccacgaa agatgccaag aaagttgcca agaaagatac      960

tgagaaagaa tctgctgatt caaagaagga tgcaaagaaa aatgctaaga aggatgcaaa     1020

gaaggatgca aagaagaatg caaagaagga tgaaaagaag gatgcaaaga agaagggcaa     1080

gtaggccttg gataagaatt tgaaccgaaa gaataattca aaagcatatt tgatgaaaca     1140

atagtggtag tctgcagctg aatttgtgag aaaacaagag gcctcaaaga attaaataat     1200

ttttaaaagg tggtaaagaa ggatacaaag gagaactcag cagagattta taaaaatata     1260

taagaaagat gttaagaaaa attaaggggg gatccattga aagacttgaa gaatacatat     1320

acttatattc ggggatatga aggattcaat gaatgatctc tagaaagatt taaagaagaa     1380

tattcagata aggatgttga agataatgac actaaatcta tggacacaca cacacacaca     1440

cacacacaca cacacacaca cacacacaca cacacacagt ttaatgaagg cttaaagaat     1500

ccaaggagac agatgttgta tctatagatt taaaataatc tcaagctgca tccacagata     1560

caaaaaaata taggagccat gaaatgaagt taaacacctt gtagaaagcc tactttcaag     1620

taaatatagc attcctttgg caaaaagaaa aaaaaagtaa aagaaaagaa aaaaaatgta     1680

ttaccacccg atgagcctac atctttcttt ctgaagttta aacaaccaca gtcatgttta     1740

tggttgttgg atgtgccact tccaatccaa aagaagcaca cttgatctac tacagaattt     1800

aagaaggcag ttgttctatt cataattgct cacaatcagc ctctcctcct actactgttc     1860

ctactctcta taccctttgt gtctgctcag actaccgtga ggatggattg gacattacac     1920

cacactggaa aagtgaaaca tctcattcag ttggtgatct tcctgtcatg aaagttgctt     1980

gacagctcta attacgaatt gaacacatta aacacctggt gaaattatca attaaaaaca     2040

tctagtcacc ata                                                        2053


<210> 3782
<211> 4279
<212> DNA
<213> Homo sapiens

<400> 3782
gacaagccgg gaagcttgga ggggtctatt gcgtacgccc aaggcgctgg gcctggagca       60

ggagaaaggg agtggaggcg cgtcggagac tatgaagcgc ggcattcggc gggatccttt      120

ccggaagcgg aagctcggcg ggcgggccaa gaaggtccgg gagcccacgg cggttaattc      180

tttttaccgt gaggcttcac ttccctcggt ctgggcttct ctgaggcggc gagagatggt      240

caggtctgga gctcgaccgg gccaggtgtt atcttcagga aggcacactg gacctgctaa      300

attaacaaat ggaaagaaag cgacctattt aagaaaaata ccacgtttta atgcagattc      360

tggctattcc atccattctg attcagaaag tcaggctgaa actgtacacg ggcttgatgg      420

ttgtgcttct ttgctgaggg acattttgag aaatgaagat tcaggttcag aaacagcata      480

tttagaaaac agatctaatt ctagaccttt agaaagcaaa agatacggat caaaaaagaa      540

aagacatgaa aaacatacta ttcctttggt agtccagaaa gaaacatcat cttcagataa      600

taagaaacag atacctaatg aagcttctgc tagaagtgaa agagacacat cagacctaga      660

gcaaaactgg tcattgcaag atcattatag aatgtattca cccataatat accaagccct      720

ctgtgagcac gtgcagactc agatgtcact gatgaatgac ttgacttcaa agaacatccc      780

taatggaatt cctgctgtac catgccatgc tccctctcat tctgaatctc aggcaactcc      840

tcattctagt tatggcttat gtacctccac cccagtctgg tcacttcagc ggccaccctg      900

ccctccaaag gttcattctg aagttcaaac tgatggcaac agtcagtttg catcacaagg      960

taaaacagtt tctgcaacct gtactgatgt tctacggaat tcatttaata ccagtcctgg     1020

agttccatgt agcctgccca aaactgacat atcagctatt ccaacattgc agcaactggg     1080

ccttgttaat ggaattctgc cacaacaagg aattcataag gaaacagacc tactaaaatg     1140

tattcaaaca tatttgtctc tttttcgatc tcatggaaaa gaaacgcatc tggacagtca     1200

gacacaccga agccctactc agtcacaacc agctttcttg gccactaatg aagaaaaatg     1260

tgccagagag caaattagag aggccacaag tgaaagaaag gatttaaaca tacatgtgcg     1320

agatacaaaa acagtgaagg atgtacagaa ggcaaaaaat gtgaacaaga cagctgaaaa     1380

agttagaatt ataaaatatt tgttgggaga gctcaaggcc ctggtagcag aacaagagga     1440

ttcagaaatt cagaggttga ttacagaaat ggaggcatgt atatctgtac ttccaacagt     1500

aagtggaaac acagatattc aagttgagat agcactggcc atgcaaccat taagaagtga     1560

gaatgctcag ttacgaaggc agttgagaat tttgaaccag caactcagag aacaacagaa     1620

aactcaaaaa ccatctggtg ctgtggattg caaccttgaa ttgttttctc ttcagtcatt     1680

gaatatgtca ctgcaaaatc aattggagga gtcactaaag agccaggaat tactgcagag     1740

taaaaatgaa gagctgttaa aagtgattga aaatcagaaa gatgaaaaca aaaaatttag     1800

tagtatattt aaagacaaag atcaaactat acttgaaaat aaacagcaat atgatattga     1860

gataacaaga ataaaaattg aattggagga agccctagtc aatgtgaaaa gctcccagtt     1920

taagttagaa actgctgaaa aggaaaacca gatattgggg ataacattac gtcagcgtga     1980

tgctgaggtg actcgactaa gagaattaac cagaacttta cagactagca tggcaaagct     2040

tctctccgat cttagtgtgg acagtgctcg ctgcaagcct gggaataacc ttaccaaatc     2100

actcttgaac attcatgata aacaacttca acatgaccca gctcctgctc acacttccat     2160

aatgagctat ctaaataagt tagaaacaaa ttacagtttt acacattcag agccactttc     2220

tacaattaaa aatgaggaaa ccatagagcc agacaaaacc tatgaaaatg ttctgtcctc     2280

cagaggccct caaaatagta acactagggg catggaggaa gcatctgcac ctggaattat     2340

ttctgccctt tcaaaacagg attctgatga agggagtgaa actatggctt taatagaaga     2400

tgagcataat ttggataata caatttacat tccttttgct agaagcactc ctgaaaagaa     2460

atcaccactt tctaagagac tatcccctca gccacaaata agagcagcta caacacagct     2520

agtcagcaac agcggacttg ctgtctctgg aaaagaaaat aaactgtgta cacctgtaat     2580

ctgttcctct tcaacaaagg aagcagaaga tgcacctgaa aaactttcca gagcatctga     2640

tatgaaggac acacagctcc tcaagaaaat aaaggaagca attggtaaga tccctgctgc     2700

caccaaggag ccagaggaac aaactgcatg tcatggccca tcaggttgtc ttagcaacag     2760

ccttcaagtg aaaggcaata ctgtctgtga tggtagtgtt ttcacttctg acttgatgtc     2820

tgactggagc atctcttcgt tttcaacgtt cacttctcgt gatgaacaag acttcagaaa     2880

tggccttgcg gcattagatg ccaacatagc tagactccag aagtctttaa ggactggtct     2940

tctggagaaa tgaattcaga agaaaactca tcaggtgctt ctttttaaaa ctagaacttg     3000

gctatattga atgtgtattt ttctttagtg aaatgatgtt ttatgttatt atgtgtgaag     3060

taatatattg tacaagtaat aaatgtattg ttgagatata ttgacactga ggagcttata     3120

aaaacaagtc atcttaagtt cacaattgct acaagaagaa agttgtggat aactaggaaa     3180

ttattgtaag taatgtttta tttcagtact tagcaattag agttctttta ttaagatgta     3240

tctgctggat taagggtaca ggttgaaata gttctgtggc tgtcctaaga aataatggga     3300

aaagaatctc tggatgtaag tttttctgtt gaaactagag ggtttttttt ttctgtttac     3360

atatactttt ttttaatagc aatgtgtttt tattaaacat gctgtgtgcc acaggccagt     3420

gttgttggtg aaatatataa acatttattt aaagagaaaa gttaccagta tctacacctc     3480

ttaaaaaaca ttgattggtc taaaaaatat atagataaca tcctaagtta acatatggct     3540

tcttaaaact tgggcacttt tatttgtttt tatcccaaat tcatgtttta aggcctttaa     3600

agaatagtca gactgataaa gaagtgctaa cagataagct atagttgggg aaatttgtgg     3660

gtttttttta aataagaaat gtttattttt gtccttatat ttaaacatga tggaatttgt     3720

aaatcttggc attgattgta attctgcctt tttggaagaa ttttttctcc cagcatgtta     3780

gctgagaata ttctctattt tataaataat atgaagtagg ttggtctctc tgcttctcta     3840

taccaggact tcttagctca gtatcatctc ccttcatgta agcagcacgt tttaactctt     3900

aggaagctga atgttgtgtt atcactaata ctttgtacag gtcacctgcc tactctaatt     3960

gtccttagta cttggacagg ctttatcatt aaagagtgtt ctcctaatcc cagaacctcc     4020

tcgtgttttt tgtttttttg gtggtttttt tttttttttt aggtgttagt gctacagcgt     4080

ttgaaggagc cagctgtagt ctctttgata tgttcagatt ttccagatag agatttaagt     4140

ctaaaaattt attaagtgaa ttctaaacta tttcacacaa gagtccatta gcatctttaa     4200

ttttatttag tattcatgaa ttaatttatt ggcatcttat ttggaggtaa taggccacaa     4260

ctctttaaca aataagttc                                                  4279


<210> 3783
<211> 2221
<212> DNA
<213> Homo sapiens

<400> 3783
aatatagatc cggcaagagc ttagctgtga tcactcctag ctgctcagca aaccactgag       60

gttcctggga aaaaaaaaaa aatatctcaa ggtaaaataa tatttagaaa aaataatgtc      120

agagcacagc agaaattcag atcaagaaga acttctcgat gaggagatta atgaagatga      180

aatcttggcc aacttgtctg ctgaagaact gaaagaactg cagtcggaaa tggaagtcat      240

ggcccctgac cccagccttc ccgtgggaat gattcagaaa gatcaaactg acaagccacc      300

gacaggaaac ttcaatcata aatctcttgt tgattatatg tattgggaaa aggcatccag      360

gcgcatgctg gaagaggaac gagttcctgt cacctttgtg aaatccgagg aaaagactca      420

agaagagcat gaagaaatag aaaaacgtaa taaaaatatg gcccagtatt taaaagaaaa      480

gctcaataat gaaatagttg caaataaaag agaatcaaag ggcagcagca atatccaaga      540

aacagatgaa gaagatgaag aagaagaaga tgatgatgat gacgacgaag gagaagatga      600

tggtgaagag agtgaagaaa cgaacagaga agaggaaggc aaagcaaagg aacaaattag      660

aaattgtgag aacaactgcc agcaggtaac tgacaaagca ttcaaagaac agagagacag      720

accagaggcc caagaacaaa gtgagaaaaa aatatcgaaa ttagatccta agaagttagc      780

tctagacacc agctttttga aggtaagtac aaggccttca ggaaaccaga cagacctgga      840

tgggagcttg aggagagtta ggaaaaatga tcctgacatg aaggaactca acctgaacaa      900

cattgaaaac atccccaaag aaatgttact ggactttgtc aatgcaatga agaaaaacaa      960

gcacatcaaa acattcagtt tagccaatgt gggtgcagat gagaatgtag catttgcctt     1020

ggctaacatg ttgcgtgaaa atagaagcat caccactctc aacatcgagt ccaatttcat     1080

cacaggtaaa gggattgtgg ccatcatgag gtgtctccag tttaatgaga cgctaactga     1140

gcttcggttt cacaatcaga ggcacatgtt gggtcaccat gctgaaatgg aaatagccag     1200

gcttttgaag gcaaacaaca ctctcctgaa gatgggctac cattttgagc ttccgggtcc     1260

cagaatggtg gtcactaatc tgctcaccag gaatcaggat aaacaaaggc agaaacgaca     1320

ggaagagcaa aaacagcagc aactcaagga acagaagaag ctgatagcca tgttagagaa     1380

tgggttgggg ctgccccctg ggatgtggga gctgttggga ggacccaagc cagattccag     1440

aatgcaggaa ttcttccagc caccgccacc tcggcctccc aacccccaaa atgtcccctt     1500

tagtcaacgc agtgaaatga tgaaaaagcc atcgcaggcc ccgaagtaca ggacagaccc     1560

tgactccttc cgggtggtga agctgaagag aatccagcgc aaatctcgga tgccggaagc     1620

cagagaacca cccgagaaaa ccaacctcaa agatgtcatc aaaacgctca agccagtgcc     1680

gagaaacagg ccacccccat tggtggaaat cactcccaga gatcagctgc taaacgacat     1740

tcgtcacagc agtgtcgcct atcttaaacc tgtgcaactg ccaaaagaac tggcgtaaga     1800

ggcaacagag ccatctagaa gaacaagaaa tggaaatagt gactcttgga ttacagcatg     1860

gagactatgt cagcagcaat actttaggat ccacgtggca gaactggaaa caatgctacc     1920

atctgataag ggtatttgta aaaggcagaa tgtttgggcc atgaagaagt aggggctgaa     1980

gaggaaggtg gaaggagata aaatataata tttagaggca atattttcta cttgcaatca     2040

atttgagtga ctcaggtgaa atttagagtc atatttcccg aagcagaagt taaagaaaat     2100

tttttaaaca tttgctttat tattgttttc ttctggtaaa taataaatat aacagaagtg     2160

ttaactattg tattcccatt tttttctcct tccatctctt ctgcggtaat tcatcacata     2220

g                                                                     2221


<210> 3784
<211> 522
<212> DNA
<213> Homo sapiens

<400> 3784
agccgggaac agctctgacc acagtaagtc atcccaaaac ctcacattca gatgaaacca       60

tttaagaatt tcatctgcac tgaggaacaa tttagcgtga tactggaggg aaagagtttc      120

cctgtgagat ccaggaggtc cctttagctc gtctcctgac gtcaccacag tcatacccaa      180

gaggaaggaa acgtcagaga caatgatttg gagaacattc tacacaaaaa ccaagtggtt      240

ccggggagaa gcctttccag gacccatgtg taggcacaac tgttttccct gatcaggata      300

cttgcggcac tcaacagagg aaagaaattc ctaagggaac actgctcaga aagtactgca      360

gcatgtcttc aaatgcctga ggatcaagtt ggaaaactag aagcaacaga aaacacaata      420

agcgcaatgg cggcggccgc ggcggagcag caacagttct acctgctcct gggaaacctg      480

ctcagccccg acaatgtggt ccggaaacag gcagaggtaa cc                         522


<210> 3785
<211> 558
<212> DNA
<213> Homo sapiens

<400> 3785
agcctccgcg gccgctgtca gggaagcgca ggcggccaat ggaacccggg agcggtcgct       60

gctgctgagg cggcagtgtc ggcagtccaa ccgcgactgc ccgcaccccc tccgcggggg      120

tcccccagag gactcaccag cgctctaagt cagatgccac tgccagcata agtctcagca      180

gcaacctgaa acgaacagcc agcaacccta aagtggagaa tgaggatgag cctgttcgac      240

tggctcctga gagagaattc atcaagtccc tgatggcgat cggcaagcgg ctggccacgc      300

tccccaccaa agagcagaaa acacagaggc tgatctcaga gctctccctg ctcaaccata      360

agctccctgc ccgagtctgg ctgcccactg ctggctttga ccaccacgtg gtccgtgtac      420

cccacacaca ggctgttgtc ctcaactcca aggacaaggc tccctacctg atttatgtgg      480

aagtccttga atgtgaaaac tttgacacca ccagtgtccc tgcccggatc cccgagaacc      540

gaattcggag tacgaggt                                                    558


<210> 3786
<211> 8478
<212> DNA
<213> Homo sapiens

<400> 3786
ggtgtcatgg ctgcttgaag tcccgggagt cggtgaggcg gctgcaggtc cctccctgcg       60

gagccgctgg tccggctggc ggagatgtga ccgcgggccc ggccggcctg cctcaggcgt      120

cgcgtcagct cccgtgtccg tgcccttaac ccacaccgat ggcgggatcc ggctgcgcct      180

ggggcgcgga gccgccgcgt tttctggagg ccttcgggcg gctgtggcag gtacagagcc      240

gtctgggtag cggctcctcc gcctcggtgt atcgggttcg ctgctgcggc aaccctggct      300

cgccccccgg cgccctcaag cagttcttgc cgccaggaac caccggggct gcggcctctg      360

ccgccgagta tggtttccgc aaagagaggg cggcgctgga acagttgcag ggtcacagaa      420

acatcgtgac tttgtatgga gtgtttacaa tccacttttc tccaaatgtg ccatcacgct      480

gtctgttgct tgaactcctg gatgtcagtg tttcggaatt gctcttatat tccagtcacc      540

agggttgttc catgtggatg atacagcatt gtgcccgaga tgttttggag gcccttgctt      600

ttcttcatca tgagggctat gtccatgcgg acctcaaacc acgtaacata ttgtggagtg      660

cagagaatga atgttttaaa ctcattgact ttggacttag cttcaaagaa ggcaatcagg      720

atgtaaagta tattcagaca gacgggtatc gggctccaga agcagaattg caaaattgct      780

tggcccaggc tggcctgcag agtgatacag aatgtacctc agctgttgat ctgtggagcc      840

taggaatcat tttactggaa atgttctcag gaatgaaact gaaacataca gtcagatctc      900

aggaatggaa ggcaaacagt tctgctatta ttgatcacat atttgccagt aaagcagtgg      960

tgaatgccgc aattccagcc tatcacctaa gagaccttat caaaagcatg cttcatgatg     1020

atccaagcag aagaattcct gctgaaatgg cattgtgcag cccattcttt agcattcctt     1080

ttgcccctca tattgaagat ctggtcatgc ttcccactcc agtgctaaga ctgctgaatg     1140

tgctggatga tgattatctt gagaatgaag aggaatatga agatgttgta gaagatgtaa     1200

aagaggagtg tcaaaaatat ggaccagtgg tatctctact tgttccaaag gaaaatcctg     1260

gcagaggaca agtctttgtt gagtatgcaa atgctggtga ttccaaagct gcgcagaaat     1320

tactgactgg aaggatgttt gatgggaagt ttgttgtggc tacattctac ccgctgagtg     1380

cctacaagag gggatatctg tatcaaacct tgctttaatc agtaacctaa ggactgtttc     1440

ctttttctcc tcttccattt cttgggttat tccacatatg aatgcaggac taccccctta     1500

ccattttaag aaggtacttt atacatttat ttaatcctac taatgtgcag ccattgccca     1560

agcagtgact gcgttgcata catttggcac tgagtaggac aagacctctc agctatacat     1620

tgaggggttt tagagcatcc atgtgggcaa cccttttttg tgcgggagag caggtgttgc     1680

tcttcagtat gtagcctaaa aaaatcttaa ttatttcatg gatcatgaag caaggatgaa     1740

taatatcatg tcttggtaaa tactaacaaa tttgttaggt ttggtgacat catttacaga     1800

ttatttcttt atgttgtcca gtggttcttc cttattgttg atatccataa gctggcactg     1860

gatgctctca gtaatgttaa gtaattgtca agcagcagtt acctactgtg ttcttaacac     1920

tgagttgtga attttttctt aaagcagtac tgtagtactg aatattcctt taaaggaact     1980

gcagtgagcc tatctaagtt tttttaaatt aaggctttta aaatagaaag ctgatgcttg     2040

atcttgcaca atttttatgt ctagtatgta tgcttgagtg aatgtgcgag tatgaatgat     2100

tagagaaaat ttgagtcagt gtactttata gtgtgaatcc tgtgagctaa tacagtctat     2160

acttatttct tccctacctg tttcacatcc gtaagattta agatatacat tttttgagag     2220

gtagtctgtc tgatacaatg taaatgacaa aacataattc ctgagaggcc cagaacaaac     2280

tggagtctag cctggagtta aattgagact tctaaaatga ttggaacaaa gactaagttg     2340

tgccagatgt aaatcaaccc ctcttttagt ttactttaga ctttgtatta gctcatcttt     2400

tttgtagtaa atctatagtt ttaaggtttc tcaagatgtg gctctaccta ctatgatgaa     2460

aattgaagtg ggtcaaaaga attagatgta cagtgaaggg aaaagaaaaa aaatgggcga     2520

agagagggtg gaaaataaaa ggattctttt ttcttccttt ctgtttctcg tatccctgct     2580

ccctttttcc tccccttccc tcattctttg cctctatcct tagctgaaga caaactagag     2640

gagcagcatc ccaggtagtt tggcttttga ctgcaaggta gttaagaaag gtgtagatat     2700

aatgaggtag aagtagaaag gaagaaaaac tcaaagaatt cttaaaagga ttcatagcaa     2760

cataatgtgt ccctgagtag aggatgctgc tatgcgtgag ttcatggaca caagttgatt     2820

acatggtttt tagaattata attatggatt cttcttattt catggtaggt tgtctttaaa     2880

gatataaaaa ttaggatgcc tttatgaagc actgattata ccaaaaaaaa aagacaagtt     2940

atatacaggt tattaatttt tttatttatt tattttttcc taaggaaaaa gtcttctatc     3000

tttccctgct ggaagcctcc tcatatttcc ttatgtttgc catgcaggtt gctgagagtc     3060

cagttagaat ttgcatttta cagaatgaaa tactttaccc cattcaaaca attattgttt     3120

gacattttag ttatttataa ttgtcaaatt caggactctc ctttaatgtt tattatgaaa     3180

ccaaatttgg cataaggagg ctgatttatg aattaccaaa gggtcttgtg gcatgttccc     3240

caatacatgc ccttagaagg aagaactatt attttttatt ttggcccttt caggagttga     3300

ttataaattg gtttgttttc aagtcagaat tcaagtgggc agaacccgta ttgtgaagac     3360

ctaaactttc ctaaatgttc atatgggtag cagattttgt ggtgattaga aacatcaggt     3420

ccttaaatac gatgaacatg ggatacaaag gaattcttta taagggcaag tatcctaagt     3480

tagcacattt acttttctct cccctccgcc cccaaaagaa aaatccttac aaataaactg     3540

caggtaggct tctaagccta gtcctgcagt atgctgctaa catcttgatg ccaatcttca     3600

cagcattctt tgattgtcat cttattgctg atacattcat acatatattt agtgcttgac     3660

actgtagaat tttgttacag aagatggtta ctagatttta agggagctga gggaataatt     3720

gatgagcctt gaattaacca tgcatttaat tagatttttt gttgttgttg ttgttgtttt     3780

gagatgatgt cttgctctgt tgcccaggct ggagtgcagt ggctcaatct cggctcactg     3840

caacctctgc ctcgcaggtt tgagcgattc tcctgtctca gcctccccag tagctgggtt     3900

tacaggcgct tgccaccaca cctggctaga tgttttatat taaagccaga gaattgaaaa     3960

agaaatgcct cctgtgattg aaattatttt atagctctta gcccgttcta ccaaagatca     4020

cattagcaga ttacccctcc ctcctgtgat attatctttc ttaaacctga accaaatatc     4080

aaaagataca agtttcatga ttaggatgaa atatatacat agggattttg gtttattgaa     4140

gttattgaaa gacctagaaa ttttcttttt gagagaaagg gtaaagaggt gagggttcat     4200

gtcacttaac ccctaccctt ttgggcaaat tttgtctcag gtagtgtttc attccctaaa     4260

ttaatacctg tgcttccttg cctctcacct tcccagttac ttctttgggg tattactgtg     4320

gcacattgta cacccagaaa aggcacatac agtgattatt ttgtgggaaa tacttgattc     4380

ttttgaaata tatttggagg gggtagctag ctagccactg tcaaaactaa tgctgtattt     4440

acaggacaaa aacaagtaga gttggacacc tcagtaagag acagcattaa ctaaaagtac     4500

tgactgcctt ttaaaggaat ttttaaaact attctcttgc aataagagat ccgcatttat     4560

taccactgga tgtcttcctt ttttgtggcc accaatatag cagctctctt tagagggatt     4620

ccctttctgc tatgccttga gccaaactgg ctgcttttag aacaaaaacc ataagtatgg     4680

ttttactcga acttctcttt gtttttattg agagaaatat tgccttcttt ttggtactcc     4740

agctgctaaa gagtgctgag atatgttaaa ttatttttta aaagaaaatc tccaaatact     4800

tatttaactt gtcttctaga ttcatgttgc ttatatttta actattgagc aagtttatta     4860

taaggaatgc tgccatatag agaaagctga agagaaacca tgggcagaag gcttttttct     4920

gtcttattac actggacctt cactctggta agggcatcag ttacttttct ggaataaaag     4980

gcggagttag agcacttatc agatgctgtt tcatggcttg ttttagttaa tttatcatgc     5040

agataactaa catttgggta tctttttgtt ttaggtctta ttttctgact gttaggccta     5100

tcttacacat aagttctact atcagtatac ttggcagcat gacttttttt tttttttaca     5160

gttaatttaa tgaaaatcag caccattgta aatgatagta attgtaacaa catagttact     5220

gggtgaagga gtaggggaga cactcagtaa ccatctattt acctagacac ttatgcaggg     5280

gtacatgcta ggtggcttta ttcagattcg ggtacattgg aatcacatca tgactttgag     5340

tctgatggct gtgtagataa agatttaagc aagtgccttg tgtttgctgg aaaatattaa     5400

aactcatttg ggtgaaagct tcccagatga tgataattaa tagcacttct gcctttttcc     5460

tggagtaact tttagattga gtcacatatg atagtataaa agtccaaaat tttctgggtt     5520

tacctttgtt ttatttttca tatatatatt cactgtctgc ctggaaatag ccttggttta     5580

ccttattttt ttgtatatgt aaaactattc atatttgatt ttattccaat attatatatg     5640

atggaaaagc cagaattgtc tggcagaatt taattcttcc ttggatctct agttctgttt     5700

ttaatatcag gttccttcat caaattttac tactgtagct ctgtgatata atttcatttc     5760

ttgtcaatta tggtcacata tagacaagta cttggtcaca attagctcaa aagaatcccc     5820

atttcttaag gtgctcagtc aatcaccttt attttgagat ggtagttttt caagttagta     5880

ttacttacta gctttcttga tgaatataaa aatgttgtct ccatcataca gagctgagcc     5940

tcttgtggta tattaagata agtcccattc ttaatcacag aagaacatgg atattttagt     6000

ttttggagta cccagaattg taaagatttt gtttcatttt gttttaggat agcttctctg     6060

cctaatacta taggatatgt catgttcgtt attgtagcca cctccctcag atgtttttca     6120

ctatttttaa attatataat gaccagtaga ttcacagtag catgtacttg acaagtgcca     6180

tggatattta agaagaaggt aaataatttt aatatttttt gctgtaattt tataggagca     6240

gtggactgta agagaaatat ctataaatca gagagtattt aggaaacttt gtattttata     6300

ggtggtcatt aaagtgatct tcaggatata agatagttta cacaaacttt attctcctga     6360

taggaaattt ttattcattt tcctaccact cagcactttt gttctgcctt gtactgctta     6420

tgaggattaa tgttttaaat ttgctttatt tgtgcttttc agagagttgt cataattgtg     6480

gcagttgtgt ttgtggcact gtaaatgctg aaattcatgg gaaacttacc aaatgactgc     6540

ttgagtgtta tttcccatta aattgggtag ctgtcacaat aaccagaaga aatcttgtgg     6600

cccttttgaa gaaagccatg tatgttttgt tacctaggtt catagtattt taatttaaag     6660

gcaaagagaa gcattctact tatttgtctt ataaaccatt aatcgttttt tgtgcagaag     6720

agagcttatt ttgttatact gctttgtata atggaaataa gtcacattct gggggaaaaa     6780

aactggaatt gtttgtattt tgtttttttg gggggggatc tttatgtgaa aaatcagagc     6840

tacttgttac cataagccct tactatcaac aagataatta tttgtaatca cttttttatc     6900

ccaggttgga attgctttcc ccttctaagt tatcttccct taataatatt tatgatacca     6960

ggacagtgag ggtataagag caaatgtagt gaggtattca aaaatcctgc atatatggac     7020

tcaaaagttc tttagttatt tgaattatat atagctatat tattttatta gcttgggttg     7080

tcagaagatt gccaatttta agagtaaaga ggagagagat aagtaataaa aatagaggag     7140

gggaagaaaa tggctccctt actggtctta gtaatcttct atatagttaa tgagctaaaa     7200

aatgatactt aaagttccag gtttggtacc gctagcatag aaacattgcc tttcctacac     7260

attcctcatc attgtttcct cagaaaatta ttttaagagt ttgtgaaacc agattaaata     7320

tctatattca gtttggccta atttttaaaa ataaatattt atactccagc ttttgtgtat     7380

ttggtgtaca tcaccactta tgcaaatcaa ggatcagaaa actggaggtt agccatctcc     7440

attatttcct tttgcacatt gggtacagtg ggtggcatta gtatgcacta gctgcaaagt     7500

cacagcacct tatggaaata agtatgttta ttataataaa aaaaagttaa gctgcatctc     7560

tgtagattat ttactttgca gactgtaaag ctgccctatc ttttccagca gaatttactc     7620

ttccattctt aattcttttt tgaaatatct taaataattt aacattcctt tataacttct     7680

taacagtgtc aaaactgggg tagaagggat tttatttttt cccaaaaggg ttccatcttt     7740

gctatctgtt gatcagcctt agaaaatcta agtatgatca ataaatttta atggttgatg     7800

gcatcctgtg tcagctggag tagttggttg tgaatattaa aacctagtac tattttccct     7860

cagtaacatg taattgctac attttttata agaaggtatg gttagaaaaa aatgtgaaag     7920

atcacttaaa ccaaagccag ttacaaggag taatctctcc tgttggttta ccttcacctc     7980

agaactacaa gaatattaca atacatagtg aatagttgtc tgtaacattt ctaccagttg     8040

tttcagtagc atattggtct tggcatttct tggcactgtg gttctgctgt attatttgtg     8100

atgtcttatt gtttgtgagc ttttgttttt tttttaaaga aaaaacaaaa actaagtggg     8160

actatgtatg tagatgtgtg tcagtaccaa aaagttattt tctcaaatcc ctaaatttct     8220

gatttccatt caagtctttt aaactctttc ctgctgaata gcaaagaact tttattttcc     8280

actttcctat attcctaaaa agtgtgaaca atgcgtttca gttgactgta ttgcatactt     8340

ttttgctgaa gactttttct gtaaacacaa ttgccttgtt cagttttgtt gtaaactgac     8400

ttaccataag atgcactgtt gataatgctt tctgatgtgt gtttgataag agtgataaaa     8460

taaaagctta aaaataaa                                                   8478


<210> 3787
<211> 1553
<212> DNA
<213> Homo sapiens

<400> 3787
cccggagccg aaacaccggt aggagcgggg aggtgggtac tacacaaccg tctccagcct       60

tggtctgagt ggactgtcct gcaggtcttg ttaagaaacc agtcctgcct tcttgccact      120

cgtgtctttc gatggctccc ttcccgaagt cccgctgcct ctaagcggag tgttaagcgg      180

ggctctcgga agccggtgga ccgagatttc cccgggtggg gcgggcgcgg tgtagcggcc      240

cgcgggctga cttgctcccg gctgtccccc ggccccagcg accatgcccc gtaaaggcac      300

ccagccctcc actgcccggc gcagagagga agggccgccg ccgccgtccc ctgacggcgc      360

cagcagcgac gcggagcctg agccgccgtc cggccgcacg gagagcccag ccaccgccgc      420

agagactgca agtgaggaac ttgataatag aagtttagaa gagattttga acagcattcc      480

tcctcccccg cctccagcaa tgaccaatga agctggagct cctcggctta tgataactca      540

tattgtaaac cagaacttca aatcctatgc tggggagaaa attctgggac ctttccataa      600

gcgcttttcc tgtattatcg ggccaaatgg cagtggcaaa tccaatgtta ttgattctat      660

gctttttgtg tttggctatc gagcacaaaa aataagatct aaaaaactct cagtattaat      720

acataattct gatgaacaca aggacattca gagttgtaca gtagaagttc attttcaaaa      780

gataattgat aaggaagggg atgattatga agtcattcct aacagtaatt tctatgtatc      840

cagaacggcc tgcagagata atacttctgt ctatcacata agtggaaaga aaaagacatt      900

taaggatgtt ggaaatcttc ttcgaagcca tggaattgac ttggaccata atagattttt      960

aattttacag ggtgaagttg aacaaattgc tatgatgaaa ccaaaaggcc agactgaaca     1020

cgatgagggt atgcttgaat atttagaaga tataattggt tgtggacggc taaatgaacc     1080

tattaaagtc ttgtgtcgga gagttgaaat attaaatgaa cacagaggag agaagttaaa     1140

cagggtaaag atggtggaaa aggaaaagga tgccttagaa ggagagaaaa acatagctat     1200

cgaatttctt accttggaaa atgaaatatt tagaaaaaag aatcatgttt gtcaatatta     1260

tatttatgag ttgcagaaac gaattgctga aatggaaact caaaaggaaa aaattcatga     1320

agataccaaa gaaattaatg agaagagcaa tatactatca aatgaaatga aagctaagaa     1380

taaagatgta aaagatacag aaaagaaact gaataaaatt acaaaattta ttgaggagaa     1440

taaagaaaaa tttacacagc tagatttgga agatgttcaa gttagagaaa agttaaaaca     1500

tgccacgagt aaagccaaaa aactggagaa acaacttcaa aaagataaag aaa            1553


<210> 3788
<211> 6821
<212> DNA
<213> Homo sapiens

<400> 3788
acacacacac acacacacac acacacacac acacacacac acacacactc tcacacattc       60

tcacatgcta gacccttcta agcagcttgt ccgtttttac acatgtatct gaactctcct      120

gcatcactct tggccatttt ctcgcattcg attgcttttg ccgtttttta tttagatcag      180

tacttgattt cattttcatt ttccagtcta ctttggggtt ctcgcagtgg ataatttagc      240

caaaatgttt ttcttgtgga gacattagct gacaattccc accacagact ggcttgtacg      300

tcctcccagg gagacctaaa cctggctccc ctcccaccgc agttcttaat attgtggata      360

agagatccat ctttctcatt ctggatacct acttagtgct catggaagaa ggggtgccct      420

gcccagcccc agctgctaag ctcacacctc ctgtcaaaaa gtcccaggac atgcacgacg      480

agaggagcaa gctggtgaat gagtatgcgt gtcgagtgct ggaacttctg gggatggggc      540

atcgtctgtt tgtgcctcgg cttctggcga cctcaaagga agaccttctg caggctgatt      600

ttgaaggtgc tttaaagttc tttagagttc agcttccaaa gagatacagg gcagaggaaa      660

atgcaagaag actgatggag caggcttgca atattaaagt accaaccaag aagctgaaga      720

aatatgagaa agaatatcag acaatgcgag agagtcagct gcaacaggaa gacccaatgg      780

atagatacaa gagggagaac cgaagattac aggaggccag catgaggttg gaacaagaga      840

atgatgacct tgcccatgaa ctagtaacaa gcaaaattgc tctacggaat gacttggatc      900

aggcagaaga caaggcagat gtgttgaata aagagctcct tttgaccaaa cagaggctgg      960

tggagactga agaggagaag aggaagcaag aggaagagac tgcccagcta aaagaagtct     1020

tcaggaaaca gctagagaag gcagaatatg aaataaagaa gactacagct atcattgctg     1080

agtataaaca gatctgttcg cagttgagta ccaggctgga gaaacagcaa gcagccagca     1140

aggaggagct ggaagtggta aagggtaaga tgatggcatg caaacactgc agtgacattt     1200

tcagcaagga gggtgctttg aaactagcag ccacaggcag agaggaccag ggaattgaaa     1260

cagatgatga gaaggactca cttaagaagc agctgagaga gatggaactg gaactggcac     1320

aaaccaaact gcagttggtg gaggccaagt gtaaaattca ggaacttgaa catcagagag     1380

gagcccttat gaatgaaatc caagctgcga aaaactcttg gtttagcaaa accctgaact     1440

ctatcaaaac ggccacgggc acccagccat tgcagccagc accggtcacc cagccaccca     1500

aggagagcac atagttccag ccttacccaa gcacaagagc acaatgttca aaccaatgga     1560

aatctgggag gattcttcct ggtgtccctt tgaaggaaag tcaaggaggc cagaaaacaa     1620

gccagaattt ttcagtagct ctcactcttt cttgtatgac acttttcaaa gggatgctat     1680

ttaaactgac ctgttctatg ttgaatacct attttccagc ttctggaagg ccatgttcag     1740

atccatcata gtattacaca ttattttgtt tgcctgatgt ttagttggaa ataagtaatt     1800

cagaactaaa tgctttttta tttagaatta ttcataatta tttttatctt acataaaaat     1860

ggagacatct gttattccaa ggttgaagtg ataagaagat ctttgtcaca ggaaaaaaaa     1920

aattgaaacc taaacatctt aagttttcag gatttattca gataaagcac actgtggggc     1980

caggcatgac cactctcagg tttcctcctg agcctgattc ccagggaagt gttaatcctg     2040

tccaaaggaa agaaccaatc agcgatcatt ggtttacttt cattttctgt tcggtacatc     2100

tggaaatgaa gtgccaggaa tagacgggct gttcagatta tacgctaggt aaaaggaact     2160

gaaattttaa taagtgtagg tcaggatcat ttgggctgtg gtattctaac agatcctttt     2220

aagaatgcca cataggactt gtgagttcct aagtacacca aagtatggac acagatgtga     2280

cttctggcaa ttataaagtt aaaggtggat attgcacctt acagacttag ggagccttta     2340

ccagagacgc ctaaaaagcc ccaggttcag ccattgtgct gaatagagtg gaatatagaa     2400

ccagggacag agtatttcat ttaacgttga tatatacttg ctaaggaaac actaacaata     2460

ctgtaacttt gttaaaggac atagtattga aatgggaaat agaggtcagg ctcacatcat     2520

cttagtttaa tgctgggcaa ctttttctga tttctgtagt tccctgaaaa tgtgtccttc     2580

gtacccataa agagatacaa atgcatttgt aacatttttg attgaatata aaacctttac     2640

agaaatactt atctcatgga aaggtaaagc tattgtttaa aaattagtgg aaatattttt     2700

tcaattatat ttaacatgcc tataaaaata gtccttgcag gaaattattt gataagagca     2760

aaactatttt tattttataa actattttgg aggcctctga tcctttcaaa ccaaccaaac     2820

tactattaga tatgtacaat aacatttgtt gatattaatc attggcctca ttgttgaaca     2880

tattatttgc aaagaatctt aaactctgta gtgccagaat gattctcatc tgtgccatat     2940

tttgcaatta aaagtaacac acccttagaa gaatcaaata agagccatct acatcccagg     3000

aggatgcacc aagttgctca cagtggatct tttcctctaa aatgatcttt tatgttctaa     3060

aaagtgaaat cccctttatc tgtgtttata ttctctacag cccataaaac tgatgtgatt     3120

gttatgttat actcatcaga taatactttt cttacataaa tctttcattg ttgttctgac     3180

atctttcatt acaaaattta ttttcttaac aaaaaggaac ataacccagc attccaagtg     3240

tctgtgttgg ctttaacatt ctctacatgg tggtctagat aagctaattt tttttttttt     3300

ttttttgtaa aatgtaatag ctagaaaatg ttatcttggc gcttgttttt gtaaatcatt     3360

tagtataggc tgttagcttt actggtactt tacgctttga ttccaagaag ccttgtgcag     3420

ttgccttatc aaatggccag ctaaattaaa gatgctcttt tgtgttgtga atttcatagt     3480

tctgtacaga gcttgtttca atttacaaaa ataagtacat tccacagaat gcctaaagtg     3540

tgtaattttc tttaaataat agtaggtgag ggagaaacat aatggctcta ggtcaatccc     3600

ttatctaaag accttgttca acttcatagt ccctttcctt ttaaagagga gaagagaaaa     3660

atcccccctg gccaggcatg gtggctcaca tctgtaatcc cagcactttg ggaggctgag     3720

gtgggtggat cacctaaggt caggagtttg agaccagcct ggccaacatg gtgaaaccct     3780

atctctactg caaaatacaa aaattagccg ggcttggtgg cgggtgcctg taatcccagc     3840

tactcgggag gttgaggcag gagaatcact tgaacccagg aggcagaggt tgcagtgggc     3900

caagattacg gcattacatt ccatccagcc tgggcgacaa gagcaaaatt ccgtctcgaa     3960

aaatcaccag gtacatacct ctcaagtttg ataagtccat cttttgagtt ttcttttagc     4020

tctttcaaaa gattacgagg gcaatacata tttttttttt ttttattctc cagccccata     4080

tcatacttgg gtatgcctgt tggtaccata agcctaaact ctccttcact gcaatgcctt     4140

tgagtcagta gcaatagtaa agactagaaa caaagaaaat tcagaatttg gtatgtgata     4200

tgattgttca tacaatatgt tataatagca atattccaaa caatatgtcc ttcactgtct     4260

attgttggaa aactcatgca tcccagcatg aagtaactcc tagttttaat tttagttatt     4320

ttgagatata tttgagaatt gcatctcttc tcttgaattt cacttagaag agattaacca     4380

gccaaatatc caggaaagtt tcaaaacatt ctagtgtttt tcatcctttg ctaggatgca     4440

ctctgtacaa aacattcctc tgaaaatcta atatttgcag tatctaagaa ttgatcattt     4500

ctattttcat taaattctgt ggaaaaaatt aaatgaatga aattcaactt cataattcag     4560

ttcatcagct tttgtatctt gagaatctaa acacgtcttt aaatctgaaa gaaaccaagc     4620

tggattttgc agtgcatatg tttgctagct tcccacatcc tgaaccatgt caaaatttgg     4680

ttttatttag ttacatataa tttaatgcaa agaaattctg ttacttaatg ttctgtttat     4740

ttatgagtgc ctatcaggaa cactaatagg aatgccattc aaccagtgtc ttctgcccct     4800

ctcccagctg ttaaattagt acttcttcat tggctttctg aaatgtcctg agtaaagtag     4860

aaaagcaacc tttgtatgga tgtggggata tttaatagta tgtatcttgt ttcatttttt     4920

tcctatgatg tattaatatt tatttttctc caacccctgc tccattttct taaaatattt     4980

tccagttaat aactagttgc tttatttcct agctgaagtg agaaaaccaa cggaaaacaa     5040

tacagatttg ggcagaggag atagagttac atctttaaag gagtgagcca gtcacccagg     5100

agaatcacat gtgtaactga tgtaggggtt taagtcttca tactttcact aaaatctgtc     5160

tactaactct cccaccaacc tttgcatcaa acacttaggt acctgcctga ttaggggggc     5220

ccctttaagg gaaaaaactt ttaaaaaatt aaatgccttg gttttgtttt atcttctggg     5280

aaagaacact tttacttgat tagcaagatg attatattat ataacttgcc cttaaaaaca     5340

ctccaaaata ctgactcctt ttctccaatt acaaatgagt gtgaagaaat tctgttgtat     5400

gatttgaaca ctattaggtt tgtatgtgtg tttaattgga agaattttat atagagtatc     5460

tctgctgctt ttgtttacct gggtaccaca caaccaaata cacattgaga tttcaagaaa     5520

tgatgatgaa agccagaagg ccagaccaca gctctgcagc ctgtttccta caaccagata     5580

taaaactctt tctcgtcgcc atgctgatag tcacactgaa ctagaactgt cccaacacat     5640

tcttcctctc tcataatggc ttccatttaa tacaggcaaa gccctttacc ttagcaaatt     5700

ctttatcttt caaaagtgac caaaatgagg acttcaacct tggctgcacc tcaataggag     5760

atgctgatct tgagttgtaa tgagaaaagt gggcatatag gagattttag tgactgcagt     5820

cagctgtctg gcattccttt ctcagtttgc atctaaaaga ctacatatgt caagcttatc     5880

tccacctgaa tttgctgcct gctataaaaa catttcatta atatatccca ttcttcctac     5940

ctccatctct ggtttgtcat tagtggtatt ctgaaaagct taagaaaaaa gaatcattga     6000

gtagaaagtg aacattttaa gttattttcc tttttcattg gcaattagtt aacatgtaaa     6060

atcttttcca ttaaactgta taacttttaa taactatata ttatatatgg gataaaatat     6120

atggactgaa ttgtgagaat ataaatgcat cgaaagactc tggtgtcatg aaagcacaag     6180

aataaggctg gagatggtcc cagatccaag atgtcccaaa agccttttgt atcagtttct     6240

ctatttttgg tattttgcat aatgcatgga tccttagttc aaatgaggga caaagtttct     6300

cagtcagccc cacttccttt ctttctaact cctacctttc ccttgcagag gaggtagtag     6360

agattctgga attgtctatt tttatgaatt ccattatttt gtccatggca tctctaatga     6420

aaacaggttc tagaataaag gagttgatta gtctgaacag tactaattaa ctacaaaata     6480

aacgttagtg atcagcctct tcctctataa acaatgacca attagacgtt tccgtaattc     6540

catgtattat gtatagtaca ctctataaat gtaaatgtaa tgcttgtcta aaaagtgcaa     6600

tttattgtac attgtcccaa caaatgttta cttttataat cgttatgaac ttgaattgga     6660

ttagtatctt gtttttatgt gtgaatgaag ccttgtgaaa taaacaaatg caactgagaa     6720

ggtaacaagg tgactgtttt tgtgagccag tgatgttttc aatgctttgt gttgcccctt     6780

tggccccatt aagcagtaat aaacatttgt tctgaagtcc a                         6821


<210> 3789
<211> 6476
<212> DNA
<213> Homo sapiens

<400> 3789
gacaaatact gcatgatttt acttacataa agtacctaaa tagttaaaac tcatagaaac       60

agaatgtgag catggattgg gcgtgaacca gagggatttt tgttttttgg gttttttttt      120

gtaaagaaca gtattgggat aattggcaac atgtgaataa ggtctgaata ttagattgta      180

attctgtatc aatgttaatt tcctggtttt gataattata ctgtggttat gttagagaat      240

ggccttgttt ttaggaaaca tttaggagta aaggagtatt gtatctgcaa acttaactct      300

aatggttcag gcaaaaagta ctgctgtgta tatatattga gagagaatat ggaaaatgtc      360

aaggttcaca gaatctgagt gaagcatata tagggcatct ttgtactatt atttcatagt      420

agaaactaca aaaaaaaatt gaaaggaatt gttccaatat gacagttact gtttcaaggt      480

gcttttatca tgggtagttt tctttaccag attttctata atatagcctt gtgtatattt      540

tttggagaaa caccatatgt aatcttacag ttatgccaga catatacctc agacagtgta      600

ctttaattgt ggtagttgtt tttggactcg atccagggta tagtattata gtgtcatggc      660

ttggattttt tattatgatt ccagccaaga catcgacata aatataccaa agggaaggac      720

cctgagagtg tgatgcagag accagtggtg tgatgttata caaggtctta tttcctacat      780

tgttggttct cactgctggc ttcatgaccc tccatcataa tccaagttat ctcaagacgt      840

ataactctta ccaacccagt ttttaaaaaa tgtattctca gtgacattct tagaaggatg      900

gagcacatat tcaagcatat aatagaatgc cgtataactt tagaaagttt ggtagttaca      960

gctcaaagct atctggagat gaaattaaat atgtgaagag aaattataaa taaaactgcc     1020

aacagtgact acatctggag ggtggaacta gggggggaat cagggacttt ctcatgtcta     1080

tttaaaatta ttttgaataa agattatatt tatctgatat aaaattatta agatataaaa     1140

tagtatacca tggaaagtgt cccttctcgc tctgtccccc agatactctg tttccctccc     1200

cagaggcaac catgattaac tgtttctggc ataactccca agatactgga tgcatgtaaa     1260

agcaaatgct tattttttcc tgtttttcta cacaaaaggt tgtccattat tgtcactttt     1320

aaaacaaaaa agtttaagaa aacaacagtg gtatatgaat ttaaaaagaa aaattaagac     1380

agtgagatgt agataaagag acagggtaga gttctcactt cctggtctaa tcaggcattc     1440

taaagaatgt acataaaagg aaccagagtt aagaactctg tcctatatca tgaattaact     1500

tgcatgtttc aaagaatttg ggactataga acatattttg ggattaatat agtctgaact     1560

tagtgtagta gttacttctg gtttaaaata gtatctcaat ttccttttca ccttaaatag     1620

acttaaggaa caaatatatg tgtagtttgc ttgacgtttt acataaaaga aatttaatat     1680

atgaattaaa ttataattgt gtatttttag gatatatcac attaattaaa acagtgaata     1740

atgtggtaca tacatataat ggaatatatt tgacctcaaa aaggaagaaa aattttgaca     1800

catgctacaa tatagatgaa gcttgaagac attatgctaa gtgaaataag ccagtcacaa     1860

aagaacaaat attgtattat ttcagttata taaagtttct agactagtca aattcataga     1920

aactaggatg atagttgcta gggtcaggga gaagagggga tggaaaggta ttgtttaatg     1980

gatgcagagt ttcagtttga gaagatgaat aaaagaaaaa aatgacatta aattttgtca     2040

agatagcata ttgaaaatat aatagaaaaa tatttgttta tctgctataa tatattatgt     2100

cataggtgtt atcttcagga aggcacactg gacctgctaa attaacaaat ggaaagaaag     2160

cgtaagtact tgaagacgtt tacaacttca gatttcaagg aatttttcag gtctttgggc     2220

tggatgacat gtcgtctacc ccagaaaatt aggtaggcct ctaccatcac aagctctgag     2280

gaacaatttt tcatgtctac ccatgttaat cattttagta tttaacagtc tttctgatct     2340

tcagaatgtg tttataaatt catcttgtac atggttggac aagctttctt gtctttgctg     2400

gaaagaaaat gactacttac taatatattt tgggaaaaat atttgtaaga atattaataa     2460

gcttgttttc caggacctat ttaagaaaaa taccacgttt taatgcagat tctggctatt     2520

ccatccattc tgattcagaa agtcaggtaa gattgaatag atacaataca cactatttta     2580

attagttttc aaatagtagc taaaaagtag gaataaaatg caaagtatta attgctctaa     2640

ggaagtatga agtctgttgc tttaaaacat cttttctacc aataatagtt tgtaaataaa     2700

caaattttaa aactacataa tttatatttt ttcctacact aacagtcata tacaaatgta     2760

ttctaaatga ctttatttct tacaggctga aactgtacac gggcttgatg gttgtgcttc     2820

tttgctgagg gacattttga gaaatgaaga ttcaggtttt ttttttttaa ttctttgctg     2880

atcaccttat ctcaagtcat tattttgatg taacaaattt ttgttttatt aataggttca     2940

gaaacagcat atttagaaaa cagatctaat tctagacctt tagaaagcaa aagatacgga     3000

tcaaaaaaga aaagacatga aaaacatact attcctttgg tagtccagaa agaaacatca     3060

tcttcagata ataagaaaca gatacctaat gaagcttctg ctagaagtga aagagacaca     3120

tcagacctag agcaaaactg gtcattgcaa gatcattata gaatgtattc acccataata     3180

taccaagccc tctgtgagca cgtgcagact cagatgtcac tgatgaatga cttgacttca     3240

aagaacatcc ctaatggaat tcctgctgta ccatgccatg ctccctctca ttctgaatct     3300

caggcaactc ctcattctag ttatggctta tgtacctcca ccccagtctg gtcacttcag     3360

cggccaccct gccctccaaa ggttcattct gaagttcaaa ctgatggcaa cagtcagttt     3420

gcatcacaag gtaaaacagt ttctgcaacc tgtactgatg ttctacggaa ttcatttaat     3480

accagtcctg gagttccatg tagcctgccc aaaactgaca tatcagctat tccaacattg     3540

cagcaactgg gccttgttaa tggaattctg ccacaacaag gaattcataa ggaaacagac     3600

ctactaaaat gtattcaaac atatttgtct ctttttcgat ctcatggaaa agaaacgcat     3660

ctggacagtc agacacaccg aagccctact cagtcacaac cagctttctt ggccactaat     3720

gaagaaaaat gtgccagaga gcaaattaga gaggccacaa gtgaaagaaa ggatttaaac     3780

atacatgtgc gagatacaaa aacagtgaag gatgtacaga aggcaaaaaa tgtgaacaag     3840

acagctgaaa aagttagaat tataaaatat ttgttgggag agctcaaggc cctggtagca     3900

gaacaagagg attcagaaat tcagaggttg attacagaaa tggaggcatg tatatctgta     3960

cttccaacag taagtggaaa cacagatatt caagttgaga tagcactggc catgcaacca     4020

ttaagaagtg agaatgctca gttacgaagg cagttgagaa ttttgaacca gcaactcaga     4080

gaacaacaga aaactcaaaa accatctggt gctgtggatt gcaaccttga attgttttct     4140

cttcagtcat tgaatatgtc actgcaaaat caattggagg agtcactaaa gagccaggaa     4200

ttactgcaga gtaaaaatga agagctgtta aaagtgattg aaaatcagaa agatgaaaac     4260

aaaaaattta gtagtatatt taaagacaaa gatcaaacta tacttgaaaa taaacagcaa     4320

tatgatattg agataacaag aataaaaatt gaattggagg aagccctagt caatgtgaaa     4380

agctcccagt ttaagttaga aactgctgaa aaggaaaacc agatattggg gataacatta     4440

cgtcagcgtg atgctgaggt gactcgacta agagaattaa ccagaacttt acagactagc     4500

atggcaaagc ttctctccga tcttagtgtg gacagtgctc gctgcaagcc tgggaataac     4560

cttaccaaat cactcttgaa cattcatgat aaacaacttc aacatgaccc agctcctgct     4620

cacacttcca taatgagcta tctaaataag ttagaaacaa attacagttt tacacattca     4680

gagccacttt ctacaattaa aaatgaggaa accatagagc cagacaaaac ctatgaaaat     4740

gttctgtcct ccagaggccc tcaaaatagt aacactaggg gcatggagga agcatctgca     4800

cctggaatta tttctgccct ttcaaaacag gattctgatg aagggagtga aactatggct     4860

ttaatagaag atgagcataa tttggataat acaatttaca ttccttttgc tagaagcact     4920

cctgaaaaga aatcaccact ttctaagaga ctatcccctc agccacaaat aagagcagct     4980

acaacacagc tagtcagcaa cagcggactt gctgtctctg gaaaagaaaa taaactgtgt     5040

acacctgtaa tctgttcctc ttcaacaaag gaagcagaag atgcacctga aaaactttcc     5100

agagcatctg atatgaagga cacacagctc ctcaagaaaa taaaggaagc aattggtaag     5160

atccctgctg ccaccaagga gccagaggaa caaactgcat gtcatggccc atcaggttgt     5220

cttagcaaca gccttcaagt gaaaggcaat actgtctgtg atggtagtgt tttcacttct     5280

gacttgatgt ctgactggag catctcttcg ttttcaacgt tcacttctcg tgatgaacaa     5340

gacttcagaa atggccttgc ggcattagat gccaacatag ctagactcca gaagtcttta     5400

aggactggtc ttctggagaa atgaattcag aagaaaactc atcaggtgct tctttttaaa     5460

actagaactt ggctatattg aatgtgtatt tttctttagt gaaatgatgt tttatgttat     5520

tatgtgtgaa gtaatatatt gtacaagtaa taaatgtatt gttgagatat attgacactg     5580

aggagcttat aaaaacaagt catcttaagt tcacaattgc tacaagaaga aagttgtgga     5640

taactaggaa attattgtaa gtaatgtttt atttcagtac ttagcaatta gagttctttt     5700

attaagatgt atctgctgga ttaagggtac aggttgaaat agttctgtgg ctgtcctaag     5760

aaataatggg aaaagaatct ctggatgtaa gtttttctgt tgaaactaga gggttttttt     5820

tttctgttta catatacttt tttttaatag caatgtgttt ttattaaaca tgctgtgtgc     5880

cacaggccag tgttgttggt gaaatatata aacatttatt taaagagaaa agttaccagt     5940

atctacacct cttaaaaaac attgattggt ctaaaaaata tatagataac atcctaagtt     6000

aacatatggc ttcttaaaac ttgggcactt ttatttgttt ttatcccaaa ttcatgtttt     6060

aaggccttta aagaatagtc agactgataa agaagtgcta acagataagc tatagttggg     6120

gaaatttgtg ggtttttttt aaataagaaa tgtttatttt tgtccttata tttaaacatg     6180

atggaatttg taaatcttgg cattgattgt aattctgcct ttttggaaga attttttctc     6240

ccagcatgtt agctgagaat attctctatt ttataaataa tatgaagtag gttggtctct     6300

ctgcttctct ataccaggac ttcttagctc agtatcatct cccttcatgt aagcagcacg     6360

ttttaactct taggaagctg aatgttgtgt tatcactaat actttgtaca ggtcacctgc     6420

ctactctaat tgtccttagt acttggacag gctttatcat taaagagtgt tctcct         6476


<210> 3790
<211> 2560
<212> DNA
<213> Homo sapiens

<400> 3790
gttggagtgg gccctgtgcc tctgctgtct cctactgcta acgagtgaac aaccaaggcg       60

atgggctgta ggatgttgat acatctgagg ggccagatgg ccaccatatc agggaaagcc      120

aatgtgtttt gaaaaatatg caaatgttca ataagaaatc aagcagaaga ttgagctgct      180

gatgtcagtt aactctgaga agtcgtcctc ttcagaaagg ccggagcctc aacagaaagc      240

tcctttagtt cctcctcctc caccgccacc accaccacca ccgccacctt tgccagaccc      300

cacacccccg gagccagagg aggagatcct gggatcagat gatgaggagc aagaggaccc      360

tgcggactac tgcaaaggtg gatatcatcc agtgaaaatt ggagacctct tcaatggccg      420

gtatcatgtt attagaaagc ttggatgggg gcacttctct actgtctggc tgtgctggga      480

tatgcagggg aaaagatttg ttgcaatgaa agttgtaaaa agtgcccagc attatacgga      540

gacagccttg gatgaaataa aattgctcaa atgtgttcga gaaagtgatc ccagtgaccc      600

aaacaaagac atggtggtcc agctcattga cgacttcaag atttcaggca tgaatgggat      660

acatgtctgc atggtcttcg aagtacttgg ccaccatctc ctcaagtgga tcatcaaatc      720

caactatcaa ggcctcccag tacgttgtgt gaagagtatc attcgacagg tccttcaagg      780

gttagattac ttacacagta agtgcaagat cattcatact gacataaagc cggaaaatat      840

cttgatgtgt gtggatgatg catatgtgag aagaatggca gctgaggcca ctgagtggca      900

gaaagcaggt gctcctcctc cttcagggtc tgcagtgagt acggctccac agcagaaacc      960

tataggaaaa atatctaaaa acaaaaagaa aaaactgaaa aagaaacaga agaggcaggc     1020

tgagttattg gagaagcgcc tgcaggagat agaagaattg gagcgagaag ctgaaaggaa     1080

aataatagaa gaaaacatca cctcagctgc accttccaat gaccaggatg gcgaatactg     1140

cccagaggtg aaactaaaaa caacaggatt agaggaggcg gctgaggcag agactgcaaa     1200

ggacaatggt gaagctgagg accaggaaga gaaagaagat gctgagaaag aaaacattga     1260

aaaagatgaa gatgatgtag atcaggaact tgcgaacata gaccctacgt ggatagaatc     1320

acctaaaacc aatggccata ttgagaatgg cccattctca ctggagcagc aactggacga     1380

tgaagatgat gatgaagaag actgcccaaa tcctgaggaa tataatcttg atgagccaaa     1440

tgcagaaagt gattacacat atagcagctc ctatgaacaa ttcaatggtg aattgccaaa     1500

tggacgacat aaaattcccg agtcacagtt cccagagttt tccacctcgt tgttctctgg     1560

atccttagaa cctgtggcct gcggctctgt gctttctgag ggatcaccac ttactgagca     1620

agaggagagc agtccatccc atgacagaag cagaacggtt tcagcctcca gtactgggga     1680

tttgccaaaa gcaaaaaccc gggcagctga cttgttggtg aatcccctgg atccgcggaa     1740

tgcagataaa attagagtaa aaattgctga cctgggaaat gcttgttggg tgcataaaca     1800

cttcacggaa gacatccaga cgcgtcagta ccgctccata gaggttttaa taggagcggg     1860

gtacagcacc cctgcggaca tctggagcac ggcgtgtatg gcatttgagc tggcaacggg     1920

agattatttg tttgaaccac attctgggga agactattcc agagacgaag accacatagc     1980

ccacatcata gagctgctag gcagtattcc aaggcacttt gctctatctg gaaaatattc     2040

tcgggaattc ttcaatcgca gaggagaact gcgacacatc accaagctga agccctggag     2100

cctctttgat gtacttgtgg aaaagtatgg ctggccccat gaagatgctg cacagtttac     2160

agatttcctg atcccgatgt tagaaatggt tccagaaaaa cgagcctcag ctggcgaatg     2220

ccttcggcat ccttggttga attcttagca aattctacca atattgcatt ctgagctagc     2280

aaatgttccc agtacattgg acctaaacgg tgactctcat tctttaacag gattacaagt     2340

gagctggctt catcctcaga cctttatttt gctttgaggt actgttgttt gacattttgc     2400

tttttgtgca ctgtgatcct ggggaagggt agtcttttgt cttcagctaa gtagtttact     2460

gaccattttc ttctggaaac aataacatgt ctctaagcat tgtttcttgt gttgtgtgac     2520

attcaaatgt catttttttg aatgaaaaat actttcccct                           2560


<210> 3791
<211> 821
<212> DNA
<213> Homo sapiens

<400> 3791
ggagccgaaa caccggtagg agcggggagg tgggtactac acaaccgtct ccagccttgg       60

tctgagtgga ctgtcctgca ggtcttgtta agaaaccagt cctgccttct tgccactcgt      120

gtctttcgat ggctcccttc ccgaagtccc gctgcctcta agcggagtgt taagcggggc      180

tctcggaagc cggtggaccg agatttcccc gggtggggcg ggcgcggtgt agcggcccgc      240

gggctgactt gctcccggct gtcccccggc cccagcgacc atgccccgta aaggcaccca      300

gccctccact gcccggcgca gagaggaagg gccgccgccg ccgtcccctg acggcgccag      360

cagcgacgcg gagcctgagc cgccgtccgg ccgcacggag agcccagcca ccgccgcaga      420

gactgcaagt gaggaacttg ataatagaag tttagaagag attttgaaca gcattcctcc      480

tcccccgcct ccagcaatga ccaatgaagc tggagctcct cggcttatga taactcatat      540

tgtaaaccag aacttcaaat cctatgctgg ggagaaaatt ctgggacctt tccataagcg      600

cttttcctgt attatcgggc caaatggcag tggcaaatcc aatgttattg attctatgct      660

ttttgtgttt ggctatcgag cacaaaaaat aagatctaaa aaactctcag tattaataca      720

taattctgat gaacacaagg acattcagag ttgtacagta gaagttcatt ttcaaaagat      780

aattgataag gaaggggatg attatgaagt cattcctaac a                          821


<210> 3792
<211> 4780
<212> DNA
<213> Homo sapiens

<400> 3792
ggcgggcgca cggccaggcc atgcctgggg aggctgcccg cgccgagctg ctgctgcccg       60

aggcggaccg acccgggccc cgcacagatc tgtcctgcga tgcggccgct gccaccacca      120

tcctgggagg ggaccggcgg gagccctgtg ctctgacccc agggcccagc cacctggccc      180

tcacgttcct gcccagcaag ccgggtgccc ggccccagcc cgagggagcc agctgggatg      240

cagggcctgg tggggcaccc tcggcctggg cggacccagg ggagggcggc ccaagcccca      300

tgctcctccc tgagggcctg tcttcccagg ctctgtccac ggaggctcct ctcccggcca      360

ccctggagcc ccggattgtg atgggagagg agacgtgcca ggccctcctg tcacccagag      420

ctgcccggac agcgctcagg gaccaggagg gtgggcacgc aagcccagac ccaccccccg      480

agctgtgttc tcagggtgat ctttctgtgc cttcccctcc cccagaccct gattccttct      540

tcacgcctcc ctccaccccc accaagacca cctatgccct gcttcctgcc tgtgggcccc      600

acggggacgc cagggactca gaggctgagc tgcgggatga gctgctggac tcgccccccg      660

cctcaccctc gggctcctac attacggccg atggggacag ctgggcctct tcaccctcct      720

gttccctcag cctgctggct ccggctgaag ggctggactt cccctcaggc tggggcctgt      780

ccccgcaggg gtccatggtg gatgaacgag agctgcaccc agcagggacc ccagagcccc      840

cgtcctctga gtccagcctc tctgcagaca gcagctcctc ctggggccag gagggccact      900

tcttcgacct ggacttcctg gccaatgacc caatgatccc cgcagccctc ctacccttcc      960

agggcagcct catctttcag gtggaggcag tggaggtgac accgctatcc ccagaggaag     1020

aagaagagga ggctgtggcg gatcccgacc caggtgggga cctggctggg gagggtgagg     1080

aggacagcac gtctgcctcc ttcctgcagt cactgtctga cctgtccatc acggagggca     1140

tggacgaggc ttttgccttc cgggacgaca cctctgcagc ctcctctgat tcagactcag     1200

cctcctacgc agaggcagat gatgagaggc tgtacagcgg ggagccccat gcccaggcca     1260

ctttgctcca ggacagtgtc cagaagacag aggaggagag cggaggtggg gccaaggggc     1320

tgcaggctca ggatgggact gtgtcctggg ccgtggaggc tgctcctcag acctcagaca     1380

gaggggccta tctgtcccag agacaggaat tgatctcaga agtaacagaa gagggccttg     1440

ctttaggcca ggagtccact gccactgtga cccctcacac tctgcaggta gccccaggcc     1500

tccaggtgga ggtggctacc agagtgaccc cacaggctgg ggaggaagaa acagactcca     1560

ccgctggaca agaatctgct gccatggcaa tgcctcagcc ctcccaggag ggcatcagcg     1620

agatcttagg ccaagagtct gtcactgcag aaaaacttcc aactccacag gaagaaacaa     1680

gcctcacatt gtgtccagac tctcctcaga acttgaagga agaaggaggg ctggacctcc     1740

cctctggcag aaagcctgta gctgcagcca cgattgtccc caggcaggct aaagaggacc     1800

tcaccttacc ccaggactcc gctatgacac cgcctctgcc cctacaagac acagatctct     1860

catcagcccc aaagcctgtg gctgcagcca cgattgtgtc ccagcaggct gaagagggcc     1920

tcaccttacc ccaggactcc gttatgacac cgcctctgcc cctacaagac acagaactct     1980

cgtcagcccc aaagcctgtg gctgcagcca cgcttgtgtc ccagcaggct gaagagggcc     2040

tcaccttacc ccaggactcc gctatgacac cgcctctgcc cctacaagac acagatctct     2100

cgtcagcccc aaagcctgtg gctgcagcca cgcttgtgtc ccagcaggct gaagagggcc     2160

tcaccttacc ccaggactcc gctatgacac cgcctctgcc cctacaagac acagatctct     2220

cgtcagcccc aaagcctgtg gctgcagcca cgcttgtgtc ccagcaggct gaagagggcc     2280

tcaccttacc ccaggactcc gctatgacac cgcctctgcc cctacaagac acagatctct     2340

cgtcagcccc aaagcctgtg gctgcagcca cgattgtgtc ccagcaggct gaagagggcc     2400

tcaccttacc ccaggactcc gctatgacac cgcctctgcc cctacaagac acagatctct     2460

cgtcagcccc aaagcctgtg gctgcagcca cgattgtgtc ccagcaggct gaagagggcc     2520

tcaccttacc ccaggactcc gctatgacac cgcctctgcc cctacaagac acagatctct     2580

cgtcagcccc aaagcctgtg gctgcagcca cgcctgtgtc ccagcaggct gaagagggcc     2640

tcaccttacc ccaggactcc gctatgacac cgcctctgcc cctacaagac acagatctct     2700

cgtcagcccc aaagcctgtg gctgcagcca cgcctgtgtc ccagcaggct gaagagggcc     2760

tcaccttacc ccaggactcc gctatgacag cacctctgcc tctgcaagac acaggcccca     2820

cctcaggtcc agagcctctg gctgtggcca cccctcaaac cttgcaggca gaagcaggct     2880

gtgccccagg gacagagcct gtggccacca tggctcagca ggaagtaggt gaggccttag     2940

gccccaggcc agcacctgag gagaagaatg cagccctccc tacagtcccg gagcctgcag     3000

ccttggacca ggtccaacag gatgacccac agccagctgc agaagctggg acaccttggg     3060

ccgcacagga agatgcggat tccactttgg gcatggaggc cctcagtctc cctgagccgg     3120

cctctggtgc tggggaggaa atagcagaag ccctttctag gcctggacgg gaagcatgtc     3180

tggaagcgcg agcgcacaca ggtgatgggg ctaagcctga ctcaccccaa aaggagaccc     3240

tggaggttga gaaccagcag gaaggaggcc tgaagccact ggcacaggaa catggaccca     3300

ggtcagcact tggaggtgca agggaggtcc ccgatgcgcc tcctgctgcc tgccctgagg     3360

tcagccaggc ccggctcctg agcccagcca gggaggaaag aggcctgagt ggcaagtcca     3420

ccccggagcc cacgcttccc tcagctgtgg ccacagaggc cagtctggac tcctgcccag     3480

agtcttcagt aggggctgtg tccagtctgg acagaggctg ccctgacgcg cctgccccca     3540

cgtctgcacc aacctcccag cagccggagc ctgtactggg tctgggcagt gttgagcaac     3600

cccacgaagt acccagtgtc cttggcaccc ccttgctgca gcccccagaa aaccttgcca     3660

agggtcagcc cagcacgccc gtggacaggc ccctgggccc tgacccttct gctcctggta     3720

cccttgctgg ggcagcccta cccccactgg agcccccagc cccctgcctg tgccaggacc     3780

cccaggaaga ctctgtggaa gacgaggagc ccccaggctc tctgggcctc ccaccgcccc     3840

aggcaggagt ccagcctgcc gctgctgctg tctcaggaac cacacagcct ctggggactg     3900

ggccgcgagt cagcctctcg cctcactccc cactcctcag ccccaaggtg gcctccatgg     3960

atgccaaaga cctggccttg cagatcttgc cgccttgcca agtgcctcct ccctctgggc     4020

cccagagccc agctggccct caagggctct cagcccccga gcagcaagag gatgaggaca     4080

gcctggagga agactcgcct cgggccctgg gctcgggcca gcattcggat agccacgggg     4140

agtcatcagc cgagctggac gagcaggaca tcttggctcc tcagaccgtg cagtgtccag     4200

cccaggcccc agcaggcggc agtgaggaga ccatcgccaa agccaagcag agtcgcagtg     4260

agaagaaggc ccgaaaggca atgtcaaagc tgggcttgcg gcagattcag ggagtcacca     4320

ggatcaccat ccagaagtcc aagaacatcc tctttgtcat cgccaagcct gatgtcttca     4380

agagcccagc ctcagacact tatgtggtct ttggcgaggc caagattgag gacctgtccc     4440

agcaagtgca caaagccgca gctgagaagt ttaaggtgcc ctcagagccc tcagccttgg     4500

tccctgagtc agcacccagg ccccgggtga ggctggagtg caaggaagag gaagaggagg     4560

aggaggaaga ggtggacgag gcggggctgg aactgcgtga cattgagctg gtgatggcgc     4620

aggccaatgt gtccagggcc aaggccgtgc gggctctgag agacaaccac agtgacatcg     4680

tcaacgccat catggaactg accatgtagc cactgaccgg aagctggagc catcctacgc     4740

cttccctcag ctctgctact caataaatcg gtgtcccttc                           4780


<210> 3793
<211> 3419
<212> DNA
<213> Homo sapiens

<400> 3793
gcggcccgcg agcgcgcctc acggctcctg tctcccctcc ctccttctct ctcacgccta       60

gcgcaatggc ggcggccgcg gcggagcagc aacagttcta cctgctcctg ggaaacctgc      120

tcagccccga caatgtggtc cggaaacagg cagaggaaac ctatgagaat atcccaggcc      180

agtcaaagat cacattcctc ttacaagcca tcagaaatac aacagctgct gaagaggcta      240

gacaaatggc cgccgttctc ctaagacgtc tcttgtcctc tgcatttgat gaagtctatc      300

cagcacttcc ctctgatgtt cagactgcca tcaagagtga gctactcatg attattcaga      360

tggaaacaca atctagcatg aggaaaaaag tttgtgatat tgcggcagaa ctggccagga      420

atttaataga tgaggatggc aataaccagt ggcccgaagg tttgaagttc ctttttgatt      480

cagtcagctc tcaaaatgtg ggactgcggg aagctgccct tcacattttc tggaactttc      540

ctggaatttt tgggaaccag caacaacact atttagatgt catcaaacga atgttagttc      600

agtgtatgca agatcaggaa cacccgtcga tcaggacgtt atctgctaga gctacagctg      660

catttatact tgcaaatgag cataatgttg ctctgttcaa acattttgca gacttgctac      720

cgggattcct acaggcggta aatgactcgt gctaccagaa tgatgattct gtcctaaaat      780

ccctcgttga gattgcagat actgttccaa agtatttgcg tcctcacttg gaagcaactc      840

tacagctaag tctaaagttg tgtggagaca ctagcctcaa caatatgcaa cgccagcttg      900

cccttgaagt gatcgtcacc ctctctgaga ctgcagctgc tatgttaaga aaacatacca      960

atattgttgc acagactatt cctcagatgt tagcaatgat ggttgatttg gaagaagatg     1020

aggactgggc aaatgcagat gaactagaag atgatgattt tgacagcaat gcagttgcag     1080

gcgagagtgc tctagatcga atggcttgcg gacttggtgg aaagctcgtt ctgccgatga     1140

tcaaggaaca cattatgcaa atgcttcaaa atcctgactg gaaataccgg catgcaggat     1200

tgatggcctt atctgccatt ggtgaagggt gccaccagca aatggaagga attctaaatg     1260

agatcgtaaa ttttgtttta ctttttctcc aggatcctca tccaagagta aggtatgcag     1320

cctgtaatgc cgtgggacag atggctacag attttgcacc tggtttccaa aagaaatttc     1380

atgagaaggt gattgcagct ctgctgcaga ccatggaaga ccaaggcaat caacgtgtgc     1440

aggcccatgc agctgctgcc ctcattaact ttactgaaga ctgtcccaag tcactactta     1500

ttccatactt ggataatttg gtgaaacatc tgcattccat tatggtactg aagcttcaag     1560

agctgattca gaaaggcacc aagttagttt tggaacaagt tgtgacatcc attgcatcag     1620

ttgccgatac tgcagaagaa aaatttgtcc cctactatga tttatttatg ccatcactga     1680

agcacatcgt tgagaatgcg gttcaaaaag aactgagact tctgagagga aaaactattg     1740

aatgcattag cctcattggt ctggctgttg ggaaggaaaa attcatgcag gatgcatcag     1800

atgtgatgca gcttttgtta aagacccaga cagacttcaa tgatatggaa gatgatgatc     1860

ctcagatctc ttacatgatc tcagcatggg ccagaatgtg caaaatcctt ggaaaagaat     1920

ttcagcaata ccttccagtg gttatggggc ctttaatgaa gacggcttca attaagcccg     1980

aagtagccct tttagatacc caagacatgg agaatatgag tgatgatgat ggttgggaat     2040

ttgtgaacct tggagatcag caaagctttg gtattaaaac tgcaggacta gaagaaaaat     2100

caactgcttg ccagatgttg gtttgctatg ctaaggagtt aaaggaaggc tttgtggagt     2160

acaccgaaca ggttgtcaaa ctgatggtcc ctttactgaa attttatttc cacgatggtg     2220

ttcgagtggc agcagcggaa tccatgcctc ttctcctgga gtgtgcaaga gtccgtggtc     2280

ctgagtatct cacacagatg tggcatttta tgtgtgatgc tctaattaag gccattggta     2340

cagaaccaga ttcagacgtc ctctcagaaa taatgcattc ttttgcaaag tgcattgaag     2400

taatgggaga tggatgcctt aataatgaac actttgaaga actgggaggt atattgaaag     2460

caaagcttga agaacatttt aaaaatcaag aattacgaca agttaaaaga caagatgaag     2520

actatgatga acaggtcgaa gagtcactac aagatgagga tgataatgat gtttatattc     2580

tgaccaaagt gtcagatatt ttacactcaa tattcagtag ctacaaagaa aaggtgttac     2640

catggtttga acagctgctt ccattaattg tcaacctcat ttgtccacat agaccatggc     2700

cagacagaca atggggatta tgcatctttg atgatgtcat agaacactgt agtccagcct     2760

catttaaata cgcagaatat ttcttaagac caatgctcca atatgtatgt gacaacagcc     2820

cagaagtcag gcaagcagct gcatatggcc tgggagtcat ggcacagtac ggtggagata     2880

attatcgccc tttttgtaca gaagcacttc ccctgctggt aagagttatt cagtctgcgg     2940

attctaagac caaagaaaat gtcaatgcta cagagaactg catctcagca gtagggaaaa     3000

tcatgaagtt caagcctgac tgtgtaaacg ttgaagaggt ccttccacac tggttgtctt     3060

ggcttccact acatgaagat aaagaagaag ctgttcagac tttcaattat ctgtgtgacc     3120

tgattgaaag taatcatcca attgttcttg gcccaaacaa taccaatctg cccaaaatat     3180

ttagtataat tgcggaagga gaaatgcacg aggcaattaa acatgaagat ccttgtgcca     3240

aacgtctggc caatgtcgtt cgccaagtac agacttctgg aggactgtgg actgagtgca     3300

tagcacagct cagtcctgag cagcaggccg ccattcagga gctcctgaac tctgcgtgaa     3360

gggccttaat gtcacccacc agaaaactaa ctccaaataa acgcttaccc tttccttta      3419


<210> 3794
<211> 1447
<212> DNA
<213> Homo sapiens

<400> 3794
gagactgcgg ggcgggccat ggcggcgaac ctgagccgga acgggccagc gctgcaagag       60

gcctacgtgc gggtggtcac cgagaagtcc ccgaccgact gggctctctt tacctatgaa      120

ggcaacagca atgacatccg cgtggctggc acaggggggg gcccatgtga ccatcaacgc      180

acgggccgag gaggatgtgg agcctgagtg catcatggag aaggtggcca aggcttcagg      240

tgccaactac agctttcaca aggagagtgg ccgcttccag gacgtgggac cccaggcccc      300

agtgggctct gtgtaccaga agaccaatgc cgtgtctgag attaaaaggg ttggtaaaga      360

cagcttctgg gccaaagcag agaaggagga ggagaaccgt cggctggagg aaaagcggcg      420

ggccgaggag gcacagcggc agctggagca ggagcgccgg gagcgtgagc tgcgtgaggc      480

tgcacgccgg gagcagcgct atcaggagca gggtggcgag gccagccccc agagcaggac      540

gtgggagcag cagcaagaag tggtttcaag gaaccgaaat gagcaggagt ctgccgtgca      600

cccgagggag attttcaagc agaaggagag ggccatgtcc accacctcca tctccagtcc      660

tcagcctggc aagctgagga gccccttcct gcagaagcag ctcacccaac cagagaccca      720

ctttggcaga gagccagctg ctgccatctc aaggcccagg gcagatctcc ctgctgagga      780

gccggcgccc agcactcctc catgtctggt gcaggcagaa gaggaggctg tgtatgagga      840

acctccagag caggagacct tctacgagca gcccccactg gtgcagcagc aaggtgctgg      900

ctctgagcac attgaccacc acattcaggg ccaggggctc agtgggcaag ggctctgtgc      960

ccgtgccctg tacgactacc aggcagccga cgacacagag atctcctttg accccgagaa     1020

cctcatcacg ggcatcgagg tgatcgacga aggctggtgg cgtggctatg ggccggatgg     1080

ccattttggc atgttccctg ccaactacgt ggagctcatt gagtgaggct gagggcacat     1140

cttgcccttc ccctctcaga catggcttcc ttattgctgg aagaggaggc ctgggagttg     1200

acattcagca ctcttccagg aataggaccc ccagtgagga tgaggcctca gggctccctc     1260

cggcttggca gactcagcct gtcaccccaa atgcagcaat ggcctggtga ttcccacaca     1320

tccttcctgc atcccccgac cctcccagac agcttggctc ttgcccctga caggatactg     1380

agccaagccc tgcctgtggc caagccctga gtggccactg ccaagctgcg gggaagggtc     1440

ctgagca                                                               1447


<210> 3795
<211> 581
<212> DNA
<213> Homo sapiens

<400> 3795
ttcgagaatg ggacatggaa tgaggcgacg gccccagcaa gccccagcag ccccagcccc       60

agccccaggc ccagcagcag cagcagcagc ccctgctctc ccgccgcccg gagaggctct      120

gcagccatga agccaaccgt cccgaggtaa tcgcagggct ggaagcccgt catcgattct      180

cagggaggct gtcagcgtgc aggggggagc ggggagtgtc gtggagacac tccgggaccc      240

ctcactcggt tccgctgtgc gtccacttag ctgtggtgtc agctgtgtct ccgctgattt      300

caggcaccgc cggtaagcag ggagcctccg cggagctccc gccgccgctc ccccttggcg      360

ccaaaggcac ccggtcccgg agcagccacg cgcggcccgt gagcctcgcc accagcgggg      420

gctcagagga ggaggacaaa gacggcgggg tgctgttcca cgtcaacaag agcggcttcc      480

ccatcgacag ccacacctgg gagcgcatgt ggatgcacgt ggccaaggtg caccctaagg      540

ggggagaaat ggtgggcgcc atcaggaacg ccgccttctt g                          581


<210> 3796
<211> 1915
<212> DNA
<213> Homo sapiens

<400> 3796
atcagaaaag ggagctcagg taccttccag agagtgagac ccagcgccct tgtctcgcac       60

ccagtaggct ttcatccccg ccatggcgga gctgatccag aagaagctac agggagaagt      120

ggagaaatat caacagctac agaaggactt aagtaaatcc atgtcgggga ggcagaaact      180

tgaagcacaa ctaacagaaa ataatatcgt gaaagaggaa ctggccctgc tggatgggtc      240

caacgtggtc tttaaacttc tgggtccggt gctagtcaaa caggagctgg gggaggctcg      300

ggccacagta gggaagaggc tggactatat cacagctgaa atatttctga ggacaatccc      360

agacccagga gatgttccag actcattttt ctgatattca gagagggcaa gagtcttggc      420

ctatgtcaca cagcagagtc caggactcca gaactccaac ctagcactct ggccagaaag      480

tcagccagag gaaggaaaac tgggaatgaa gagtcagagg tgagaagcta aagtcatgat      540

ctcaccaagg gatcaagagg tcgatattgg cggcttgtga cggtaaacac ggcaccatcc      600

tcctcctcat cccagacgga cacaggggcc tggaggagca aggaagggga agtcagacag      660

ttccacacca ccccccattg ccctcagcct tcaccccagg ccctgctcct ccctctgtac      720

ccctcacctg tggtggcagg gcatagtacc agcgagtgcg aggaagggtt gggggagctg      780

gtgaccccag gtctccccca ctggggccca gacagcccca ccccagccgc ctcagggccc      840

cggtggagtc gaaggggctg cagtggaggc gtggatggag tacaggaatt ctgatcctgg      900

agacccccaa agccccttct ccccagagct gaacccacac acgacagaga agcagggtac      960

aaagggcagg agagggaagc gagaggcagc aagccagagg cagcgactag gggtagctga     1020

aacctcagtc caggcactgc cgcatgcccc gcccctcccg gccaaggact ataccagccc     1080

agagaattag tctttttcag gacccctttc accctggtcc ctcgggtagc gcctccacta     1140

tctcagccct aagggacccc cgaaggtagc agctccaatc ccagtacagg aaggaaaagg     1200

ggaagtggga tgataggggg ttgggggcgg tagactcaga gagtcacgtg gccccagccc     1260

ctcccccgac cgatcccgaa aaaccagccc tgccagtcaa cctgccctca cctaggatct     1320

ggacctagga gtttagggcc tcggggcccc aaatccaaat tctggcccct cctgaggccc     1380

gaaatcctgc tcctggccac caccattaat ccctaatgaa aacagatgac cactctctac     1440

ccaccctagg atctttcctc caggtcccag aaccgtggct tcccggcctc tacccaggac     1500

cggggcgggg cgggggggcg gggggaaggg ggagagaggg aaggaggggt cacgaaatct     1560

gagggttccc tccccaatcc cagagtcaga ggagctggtt actgtggaaa caaacccctc     1620

cccgccaaac aaaaacaagg agggagacag ggaccaagac acgactgctc agagaggtag     1680

gcacactcag gcaggcagag gtggagggcc aaagacccgc agggacagga cagccagcca     1740

gaagttccag gcaggaacag ggcaggttcc tgcgggcagg tcctgagtca cactgacaga     1800

gaaccacgga gacgccagga ctccccgcag cagagaaacg ggccgacacc cagggaggcg     1860

cgagaataac tgaggcaagg aggaggagat gtagggaccc agagacaaga gaaaa          1915


<210> 3797
<211> 4130
<212> DNA
<213> Homo sapiens

<400> 3797
agactaccgg cggcgacgac cacaggagca tggcggacac cgacctgttc atggaatgtg       60

aggaggagga gttggagcca tggcagaaaa tcagtgatgt cattgaggac tctgtagttg      120

aagattataa ttcagtggat aaaactacca cagctggcaa tcctttggtc cagcaaggtg      180

gacagccact catcctgacc cagaatccag ccccaggtct gggcacaatg gttactcaac      240

cagtattgag gcctgttcag gtcatgcaga atgccaatca tgtgactagt tcccctgtgg      300

cctcacaacc aatatttatc actacgcagg gatttcctgt aaggaatgtc cggcctgtac      360

aaaatgcaat gaatcaggtt gggattgtgc tgaacgtaca gcaaggccaa acggttagac      420

caattacact agttccagcc ccaggtaccc agtttgttaa gccgacagtt ggagttccac      480

aagtgttctc ccagatgacc cctgtgaggc caggctccac aatgcctgtg aggcccacca      540

ccaacacctt caccaccgtc atcccggcca ctcttaccat tcgaagcacc gtcccacagt      600

cccagtccca gcagaccaag tccactccca gcacttctac cactcccact gccacacagc      660

caacctcact ggggcaacta gctgttcagt ctccaggcca gtcaaaccag accacgaatc      720

ccaagctagc tccctccttc ccctctccac ctgcagtgag cattgccagc tttgtcactg      780

tgaagcgacc tggtgttaca ggcgaaaata gcaatgaagt ggccaaattg gtgaataccc      840

ttaacaccat cccttccctg ggccagagtc ctgggccagt ggtggtgtcc aacaacagct      900

ctgctcatgg ctctcaaaga accagcggac ctgagtcttc aatgaaagtg acctcttcca      960

tcccagtatt tgacctccag gatggtggac ggaaaatatg tccacgatgt aatgctcaat     1020

ttcgtgttac tgaagctttg agaggtcaca tgtgttactg ttgcccagaa atggttgaat     1080

accagaagaa aggaaagtcc ctggattcag aacccagtgt cccatcagca gcaaagcccc     1140

catcccctga gaaaacagct cctgttgctt ccacaccctc ttctacacct attcctgctc     1200

tgtcaccgcc taccaaagta ccagaaccaa atgagaacgt gggcgatgcc gtccagacca     1260

aactcattat gcttgtagat gacttctact atggacggga tggtggcaaa gtagcccagc     1320

tcacaaattt ccctaaggtc gccacatctt tccgatgccc acattgtacc aaaaggctaa     1380

aaaacaatat tcgattcatg aaccatatga aacaccacgt agaactcgat cagcagaacg     1440

gtgaggtaga tggtcacact atctgccagc actgttaccg ccagttttcc actcccttcc     1500

agcttcagtg ccacttggaa aatgttcata gtccctatga atctactacc aagtgcaaga     1560

tctgtgaatg ggcgtttgaa agtgagccac tatttctcca gcatatgaag gatactcata     1620

agcctggaga gatgccttat gtttgccagc cttattttcc ctcctatgtg actcaggtgt     1680

gtcaatatcg ctcctcactc tactctgagg tagatgtcca ttttcggatg atccatgagg     1740

atacccggca tctgctctgc ccttattgcc tgaaggtctt caaaaatggc aatgcattcc     1800

aacagcatta catgaggcac cagaagagaa atgtttatca ctgcaacaaa tgccggctgc     1860

agtttctctt tgccaaggac aaaattgaac acaagcttca acaccataaa accttccgta     1920

aacccaagca gctggagggc ttgaaaccag gcaccaaggt gacaatccgg gcttcccgag     1980

ggcagccacg aactgttcct gtatcctcta atgatacacc tcccagcgcc ttgcaggagg     2040

cagcaccgct gacctcctca atggaccctc tgcctgtctt cctttatccc cctgtccagc     2100

gcagcatcca gaagagagct gttaggaaaa tgagtgtcat gggccggcag acatgcctgg     2160

agtgcagctt cgagatccca gacttcccta atcatttccc tacttacgta cactgctctc     2220

tgtgtcgcta tagcacctgc tgttctcgag cttatgccaa ccacatgatc aacaatcatg     2280

ttccacggaa gagccccaag tatttggctt tgtttaaaaa ttctgtgagt ggaatcaagc     2340

tggcctgcac ttcatgtacc tttgttacct ctgtgggcga tgctatggcc aagcatttgg     2400

tattcaaccc ctctcacaga tccagcagca tcctgccacg gggactcact tggatagctc     2460

actcaaggca tggccagact cgtgaccgag tgcatgaccg gaacgtgaag aatatgtacc     2520

ctcctccttc cttccccact aacaaagctg ccactgtgaa atctgcgggg gccaccccag     2580

ctgagcctga agagctacta actcccttag ccccagcact cccatcacca gcctcaactg     2640

caaccccacc accaaccccc actcacccgc aggctttagc ccttccaccg ctggctacag     2700

agggagccga atgtctgaat gttgatgatc aggatgaagg gagcccagtc acccaagaac     2760

ctgagctagc atcaggtggt ggtggtagtg gtggagttgg caaaaaggag cagctgtctg     2820

tgaagaagct tcgagtagta ctgtttgctc tatgctgcaa tacagaacag gcagctgaac     2880

acttccgaaa tccccagcga cgtattcgcc gttggcttcg acgtttccag gcctcccagg     2940

gggagaatct agagggcaaa tatctgagct ttgaggcaga agagaaactg gctgagtggg     3000

tgctaaccca gcgcgaacaa cagctacctg taaatgagga gaccttgttc cagaaggcca     3060

ccaaaatagg acgttctttg gaaggggggt ttaagatctc ctatgagtgg gctgtgcgtt     3120

tcatgctgcg gcaccacctg actccccatg cccggcgagc tgtggcccac accctaccta     3180

aggatgtagc agagaatgca ggactcttca ttgattttgt acaacggcag attcacaacc     3240

aggacttacc cttgtctatg attgtggcta ttgatgagat ctctttgttc ctggatacag     3300

aggtgctgag cagtgatgat cgaaaggaga atgccctgca gacagtgggc acaggggaac     3360

cttggtgtga tgtagtccta gccattctgg cagatggcac tgtccttccc accctggttt     3420

tctacagagg gcagatggat cagcctgcta acatgccaga ctccatattg ctagaggcaa     3480

aggagagtgg ctacagtgat gacgagatca tggagctgtg gtcaactcga gtgtggcaga     3540

agcacacagc ttgccagcgc agcaaaggca tgcttgtgat ggactgtcat cgcactcact     3600

tgtcagaaga ggtactggct atgcttagtg cctctagcac tttgcctgca gtggtcccag     3660

caggctgtag ctccaaaatt cagccattag atgtatgcat caaaagaact gtcaagaact     3720

tcctgcataa aaaatggaag gaacaggctc gggaaatggc agatactgca tgtgattctg     3780

atgtcctgct tcagctggtg cttgtctggc tgggtgaagt gctaggtgtc attggggact     3840

gtccagagct agttcagcgc tccttcctgg tggctagtgt tctgcctggc cccgatggca     3900

acattaactc acctacaaga aatgctgaca tgcaggagga gctaattgcc tccctagagg     3960

agcaactgaa gctgagtggg gaacattctg agtcttccac tccacgaccc agatcatctc     4020

ctgaagagac aattgagcct gaaagtcttc accagctctt tgagggtgaa agtgagaccg     4080

agtctttcta tggctttgaa gaagctgacc tagatctgat ggagatttga                4130


<210> 3798
<211> 686
<212> DNA
<213> Homo sapiens

<400> 3798
agggcggcac cactccctgc tccatggaaa ctgagcaagt tgtacaggta gccaggtgtc       60

ggtctccagc ctgagaactc tggctgttgt tccttgtgtc gtcccatatt cctgcctggc      120

ctgcgatgga catcagcaag ggcctcccag gcatgcaggg aggcctccac atatggatct      180

ctgagaaccg gaagatggtg ccggtacccg agggggctta cgggaacttt tttgaggaac      240

actgctatgt catcctccac gtcccccaga gcccgaaggc cacgcagggg gcgtccagcg      300

acctgcacta ctgggtcggg aagcaggcgg gtgcggaagc gcagggcgct gcggaggcct      360

tccagcagcg cctacaggac gagctggggg gccagaccgt gctgcaccgc gaggcgcagg      420

gccacgagtc cgactgcttc tgcagctact tccgcccggg aatcatctac aggaagggag      480

gcctagcatc tgacctcaag catgtggaga ccaacttgtt caacatccag cgactgctgc      540

acatcaaagg gaggaagcac gtgtctgcca ctgaggtgga gctctcctgg aacagcttta      600

ataagggtga catcttcctg ctggacctag gcaagatgat gattcagtgg aatgggccca      660

agaccagcat ttctgagaag gctcgg                                           686


<210> 3799
<211> 1495
<212> DNA
<213> Homo sapiens

<400> 3799
gcagccggtc gtaaccaagt tgtgtcctgt cagccgctgt ccccttcgcc gcgatgccgc       60

tggagaacct ggaggaggag ggtctgccca agaaccccga cttgcgtatc gcgcagctgc      120

gcttcctgct cagcctgccc gagcaccgcg gagacgctgc cgtgcgcgac gagctgatgg      180

cggccgtccg cgataacaac ttttggaaca gaatccggca agagcaaacc gaggattgcc      240

ctccctccag ccctagtaga ggttggcatt gccaggattg gccgtcacgc aaacctccca      300

ccagcatacg tttatgtttt gccaagccga ttattaagcg ccatcgcatg ccttcctaca      360

tggctcctta ctatgaagcc ttgtgcaaat ccctcgactg gcagatagac gtggacctac      420

tcaataaaat gaagaaggca aatgaagatg agttgaagcg tttggatgag gagctggaag      480

atgcagagaa gaatctagga gagagcgaaa ttcgcgatgc aatgatggca aaggccgagt      540

acctctgccg gataggtgac aaagagggag ctctgacagc ctttcgcaag acatatgaca      600

aaactgtggc cctgggtcac cgattggata ttgtattcta tctccttagg attggcttat      660

tttatatgga taatgatctc atcacacgaa acacagaaaa ggccaaaagc ttaatagaag      720

aaggaggaga ctgggacagg agaaaccgcc taaaagtgta tcagggtctt tattgtgtgg      780

ctattcgtga tttcaaacag gcagctgaac tcttccttga cactgtttca acatttacat      840

cctatgaact catggattat aaaacatttg tgacttatac tgtctatgtc agtatgattg      900

ccttagaaag accagatctc agggaaaagg tcattaaagg agcagagatt cttgaagtgt      960

tgcacagtct tccagcagtt cggcagtatc tgttttcact ctatgaatgc cgttactctg     1020

ttttcttcca atcattagcg gttgtggaac aggaaatgaa aaaggactgg ctttttgccc     1080

ctcattatcg atactatgta agagaaatga gaattcatgc atacagtcag ctgctggaat     1140

catataggtc attaaccctt ggctatatgg cagaagcgtt tggtgttggt gtggaattca     1200

ttgatcagga actgtccagg tttattgctg ccgggagact acactgcaaa atagataaag     1260

tgaatgaaat agtagaaacc aacagacctg atagcaagaa ctggcagtac caagaaacta     1320

tcaagaaagg agatctgcta ctaaacagag ttcaaaaact ttccagagta attaatatgt     1380

aaagccatgt aactaacaaa ggatttgctt tagagataat tatttggaat ttttatagct     1440

tacttcacaa tgtgcccagg tcagctgtat aaaataaata ctgcattgtt gtttc          1495


<210> 3800
<211> 2069
<212> DNA
<213> Homo sapiens

<400> 3800
agtctcttcc ccaactctcc ccacccctgg tgctctccgc cccgcttgcc tcccgttctt       60

ccccgcccgc tccatccggg tcgctgacgg ctgtctctgg actggacagc agtggcgtcc      120

gcttttctct aaggaacccg ataagaactc cattttctgt tgatgtggag acatagggta      180

cctccaactt tccggggttt cagaagagaa ttttttattg aaactggaag accaaaataa      240

ttacaagcat gttgtgctgg ggaaatgcat cctttgggca gctaggtttg ggtggaattg      300

atgaagaaat tgtactagag cccagaaaaa gtgacttctt tataaataaa agggtccgag      360

atgtaggatg tggactcaga catactgtgt ttgttctgga tgatggaaca gtgtacacat      420

gtggatgtaa tgatctagga cagctaggtc atgaaaaatc cagaaagaaa ccagagtttc      480

gctcttgttt cccaggccgg agtgcaatgg cgccatctcg gctcaccgca acctctgcct      540

cccaggttca agcaattctc ctgcctcagc ctcccgaata gctgggatta caggcgccca      600

ccacaatgcc tggctacttt tcatatttta atggagatgg ggttttacca tgttggccag      660

gctggtctcg aactcctgac ctcaggtgat ccgcctgcct tggcctcccg aagtgctgga      720

attacaggca tgagccactg ctcctggcct aagatgtttt ttaaataatg tttttaacta      780

aattttaaga atgtttttaa ctaaagttat ttatatttgg aataattcgt taatgatttg      840

tgtcatttcc ccaacccctt tttaaatttg tgaatttgag gactggatta aaagataaaa      900

agttgttgga tcttatttat tttaaagtct tctggtaatt gagcaagttg gttatatttc      960

tgggacaatg taataaacat agttcatttc ccaggaggtt tttgttttgt tttgttttgt     1020

ttcgttttgt ttgagacaga gtctcactct gttgcccagg ctggaatgca gtggcacgat     1080

ctctgctcac tgcaacctcc gcctcccagg ttcaagcgat tctcctgcct cggcctcccg     1140

agtaggtggg actatagggg cgtgccacca tgcccgggta attttttata tttttagtag     1200

ggacggggtt tcaccgtgtt agccaggatg gtcttgatat cctgaccttg tgatctgccc     1260

gccttggcct cccagagtgc tgggattaca ggcgtgagcc accgtgccca gctgacttca     1320

caagaacttt aaacttgtgt cagaaagcac atggaatgga gggaactaag aattgtttct     1380

ttacataggt tggctttata aatatacata ttccataact aataaggaat gaaggagaaa     1440

gaggtagcct tattaaggat aaattattct cgagattcat aataacctac tggaggactt     1500

ggcctgacaa tgtagtgaat agatttaacc tgtggcctat tgaaaagagg tgtttctgtt     1560

ctggactttt tagggaccac acagaaagat ttaactgaat tcctttatta tactaaaggt     1620

gcagattatg ttcatgttca tctctgttgt cttgtatatg tatgtccttt tctatcacta     1680

ctggcttttc tgaattattt ccagagaagt gaatgtctgt ttcactttca tgtttttttc     1740

ttcataagaa ctttaaaata ctttttaagc taatgtctca atttttaaat ttatagctaa     1800

caaatatatt taatcttcag tgcgctagac caatccattt aaatgaattg ttgttttttt     1860

atactttcaa attcagttct gaagatttta agtatgggaa gtatactttt ctttacaaga     1920

tccttttctt actgtgtatc taatcatagg tataatttgg tgaccatggt tatgttttgc     1980

acattgattt ccatttgttt catgttagaa acagtactaa actgttctgt gaccataatt     2040

tgtaaataaa gtggtgttct gtttaaaaa                                       2069


<210> 3801
<211> 1046
<212> DNA
<213> Homo sapiens

<400> 3801
agagaatttt gcaacacgtg gtagtgaact gtgaggagtt tgaggggtct gaagactgaa       60

agagtcgaat ggtttgttgg cagtctgtgt ctgtgtggag tgttgcagga cgagtggaaa      120

tgactgtttc caagttcatg gcaattcaga aggcccttca gccagactgg ttccagtgcc      180

tctccgatgg agaagtatct tgtaaggaag caacttccat aaaaagggtc agaaagtctg      240

ttgaccgatc acttcttttc ttggataact gtctgcggct gcaggaagag tcagaggttc      300

ttcagaagag tgtgatcatt ggagtgattg aaggtggaga tgtgatggaa gagaggctga      360

ggtcagcacg agagacagcc aagcggcctg tgggtggctt ccttctggat ggttttcaag      420

gaaatccaac aaccctggag gctagactac gcttgctgtc atcagtcact gcagagctgc      480

cggaggacaa gccaaggctc atatctggtg ttagtcggcc agatgaggtg ctcgagtgta      540

ttgaaagagg agtggactta tttgagagtt ttttccctta tcaagtaaca gagcggggat      600

gtgccctgac tttcagtttt gattaccagc cgaatcctga agagacacta ctacaacaaa      660

atggaacaca agaagaaata aaatgtatgg atcaaataaa gaaaattgaa acaactggtt      720

gcaaccaaga aataacatca tttgaaatta atctgaagga aaaaaagtac caggaggact      780

ttaacccgct ggtgagagga tgttcctgtt actgctgtaa gaatcacact cgggcataca      840

tccaccatct gctggtgacc aatgagctgc tggccggagt cctgcttatg atgcacaact      900

ttgaacacta ctttgggttt ttccattaca tccgggaagc actaaaaagt gacaaactgg      960

cacagttgaa agagctcatc cacaggcaag catcttgaga tcttgcaaat acaagtctca     1020

ctcttcacac tgagcctgta ccactg                                          1046


<210> 3802
<211> 627
<212> DNA
<213> Homo sapiens

<400> 3802
acatgtttcc tttgttgtga gctgcggcag agactggtgg ctggaggaga cgccggcgct       60

ggagagtgcg ctgcgccgcc cgccgctgag ggaccgcggg gttagccact gctggctgct      120

tccagtgttc gccgagaggt accgggggtg acagctccgg gaccggccga aaggcgagga      180

accgccacat aaagaagatc cctaatagtc atttctcaac aattatatag tcaactgatg      240

taacaatggt actaatattg ggacgcagac taaacagaga ggatcttggg gtgcgtgatt      300

ccccagcaac taagcgaaaa gtttttgaaa tggaccccaa atctctgaca ggtcatgagt      360

tttttgactt ctcttcagga tcatcccatg ccgaaaacat actccagata tttaatgaat      420

ttcgtgatag ccgcttattc acagatgtta tcatttgtgt ggaaggaaaa gaatttcctt      480

gccatagagc tgtgctctca gcctgtagca gctacttcag agctatgttt tgtaatgacc      540

acagggaaag ccgagaaatg ttggttgaga tcaatggtat tttagctgaa gctatggaat      600

gttttttgca gtatgtttat actggaa                                          627


<210> 3803
<211> 1815
<212> DNA
<213> Homo sapiens

<400> 3803
agaggctgtg gtggccccga gcgcgagtgt gtaggtgaca ggacagcggc caggcccgcc       60

cctcccctcg tgatggtcat tgtcctccag agcagtgatg gaggaaatac cagcccagga      120

agcagcaggg tcaccaaggg tccagtttca gtctttggag acccagtctg agtgtctgtc      180

cccagagcct cagtttgtgc aggacaccga catggaacag ggactcactg ggggatttcc      240

aatttccaag cctgatggga tctcccagct ggaacaggat ctacaggtct ttgatctgga      300

aactaagact agagaagtct taagagatga ctgctcagat ggagagacca gagaagagaa      360

caagctgttg attcctaagc agaaaatttc ggaagaagtg cattcataca aagtgagagt      420

aggaagactc aaacacgata ttacccaagt tcctgagact agagaagtgt ataagtctga      480

ggacagatta gaaagacttc aggaaattct aaggaaattt ctgtacctgg agagagagtt      540

taggcaaata acaatcagca aggaaacctt caccagtgag aagaacaatg aatgtcatga      600

acccgaaaaa agcttcagtc tggactctac tattgatgca gatcagagag ttcttagaat      660

acagaatacc gatgacaatg ataagtatga catgagcttc aaccagaatt cagcctctgg      720

taaacatgaa cacttaaatc taacagagga ttttcagagt agtgaatgta aggaaagctt      780

aatggatctc tcccacctta ataaatggga gagcatccct aacactgaga aatcctataa      840

atgtgatgta tgtgggaaaa ttttccatca gagctcagcc cttactagac atcagagaat      900

ccatactaga gagaagccct acaaatgtaa agaatgtgaa aagtctttca gtcagagctc      960

aagtcttagt cgacataaaa gaatacacac tagagaaaaa ccttacaaat gtgaagcatc     1020

tgataaatcc tgtgaagcgt ctgataaatc ctgtagtcca agctcaggca taattcagca     1080

taagaaaatt cacaccagag ccaaatctta caaatgtagc agttgtgaaa gagtcttcag     1140

tcgtagtgtc caccttactc aacatcagaa aattcacaaa gagatgccct gtaagtgtac     1200

tgtatgtggc agtgacttct gccatacttc atacctactt gaacatcaga gggtccatca     1260

tgaagagaaa gcctatgagt atgatgaata tgggttggcc tatattaaac aacaaggaat     1320

tcatttcaga gaaaagccct atacgtgtag tgaatgtgga aaagacttca gattgaattc     1380

acatcttatt cagcatcaaa gaattcacac aggagagaaa gcacatgaat gtaatgaatg     1440

tggaaaagct ttcagtcaaa cctcatgcct tattcagcat cacaaaatgc ataggaaaga     1500

gaaatcgtat gaatgtaatg agtatgaggg cagtttcagt catagctcag atcttatcct     1560

gcaacaagaa gtcctcacca gacagaaagc ctttgattgt gatgtatggg aaaagaactc     1620

cagtcagaga gcacatctag ttcaacatca gagcattcat accaaagaga actcatgaat     1680

gtaatgaaga tgggaagata tttatcaaat tcaggcttca ttcagcatct gagagttcac     1740

accagggaga aatcatgtat gtactgcatg tggtaaagcc ttcagtcata gctcagccat     1800

tgctcagcat cagat                                                      1815


<210> 3804
<211> 544
<212> DNA
<213> Homo sapiens

<400> 3804
acaactggag cagccgggaa cagctctgac cacagtggtt ccggggagaa gcctttccag       60

gacccatgtg taggcacaac tgttttccct gatcaggata cttgcggcac tcaagaattc      120

tccgaagttt gaaggttatg aatggttatc actcaaggat tcagaactaa gatactttcc      180

cagcaacatc tagactgctg tttgaccaaa caacggggct ccaacagcct agccaagtga      240

aacataaaac taaccatcac agtatccttg tcaaaaatca gtctgacaac acatcagagg      300

aaagaaattc ctaagggaac actgctcaga aagtactgca gcatgtcttc aaatgcctga      360

ggatcaagtt ggaaaactag aagcaacaga aaacacaata agcgcaatgg cggcggccgc      420

ggcggagcag caacagttct acctgctcct gggaaacctg ctcagccccg acaatgtggt      480

ccggaaacag gcagaggaaa cctatgagaa tatcccaggc cagtcaaaga tcacattcct      540

ctta                                                                   544


<210> 3805
<211> 4476
<212> DNA
<213> Homo sapiens

<400> 3805
ataggtgcat tgtgggaagc actttgctgt ccacagccag gccgcttgtg atgaaactgt       60

aacttacaag aaaagggctg ggttttgaaa ataacacagg ctctaaaaac cctaagaagc      120

ggtgcaactt ttggcaggaa tcggggttag cgggacctca agggctcact gcggctaagt      180

gaacgctgac tggtcctcca gcgtgagcta gaacagacgt ctctatggtc aagtaaacag      240

agcgtgtgct gtcttcccca tgtggtgggg ttgcgcatga tcagtagctg caccactaga      300

aagatggcgg agcaagagca aagaaaaatc cctttggttc cagaaaatct cctgaaaaag      360

aggaaggctt atcaagccct caaagccacc caggcaaagc aggcactttt ggcaaagaag      420

gagcagaaga aaggaaaagg gctcaggttt aagcgactgg aatcattcct acatgattcc      480

tggcggcaga aacgtgacaa ggtgcgtctc agacgactag aagtgaaacc tcatgccttg      540

gaattgccag ataaacattc cttggccttt gttgtacgca tcgaaaggat tgacggcgtg      600

agtttactgg tgcagagaac cattgcaaga cttcgcctaa agaaaatttt tagtggtgtc      660

tttgtaaaag tcacccccca gaatctaaaa atgctgcgta tagtggaacc ttatgtgacc      720

tggggatttc caaatctgaa gtctgtccga gaactcattt tgaaacgtgg acaagccaag      780

gtcaagaata agaccatccc tctgacagac aatacagtga ttgaggagca cctggggaag      840

tttggcgtca tttgcttgga agacctcatt catgaaattg ccttcccagg gaagcatttc      900

caggagatct catggttctt gtgccctttc cacctctcag tggcccgtca tgctaccaaa      960

aatagagtgg gcttcctcaa ggagatgggc acacctggct atcggggtga acgcatcaat     1020

cagctcatcc gtcagctgaa ctagacccag gtgaggcagg gctgaaaact gcccttgggc     1080

tgacttttga taggccatgc cttgccactt tacaagttct ttttgcattt actagtattt     1140

aagagtaacc ttgagattgg gaggaataga ggaggctggt acaaatagat ggagacctgc     1200

tgggatcagt gaatgcctga ttaggacatg gggctatgca tagcctaaga gttataggct     1260

taaagatgtc gagtaactaa aaactgtatt gctggccggg cgcggtggct cacgcctgta     1320

atcccagcac tttgggaggc caaggcgggc agaccatgag gtcaggagat tgagaccatc     1380

ctggccaaca tggtgaaacc ctgtctctac taaaaataca aaaatgagct gggtgtggtg     1440

gcgcgtgcct gtagtcccag ctactcgaga ggctaaggca ggaaaatcgc ttgaacccag     1500

gaggcagaga ttgcagtgag ccaagattgc accagtgcac tccagctggg cgacagagcg     1560

agactccatc tcggaaaaaa aaaaaaaaaa actattgctg cagtcattca gatggaaatg     1620

aggaaagaat aatattaata actgatttca aaaaggactt gaagatgtga atcatctatt     1680

ttgctgaaga aatcttaact ctttgaaatt actttttatt gctgttgtca tactcttagg     1740

tgccaaactg cggtaaattt tttatcagtg aagtggaagc atgtgttttg ttttggaaat     1800

ttttatcaag tatcttcaga gaagattatt tcctgcttta tcttcagaaa ctggaaaggg     1860

tcaaagaaaa gacagtagct ggccggtcgt ggtggctcat gcctgtaatc ccaacactta     1920

gggaggctga ggtgggcaga tcacctgagg ttgggagttc gagaccagcc tgaccaacat     1980

ggagaaatgc catctctact aaaaatacaa aaattagccg ggcatggtgg cacgtgcctg     2040

taatcccagc tactcaggag gctgaggcag gagaatcgct tgaacctggg aggtggaagt     2100

tgcagtgagc tgagatcacg ccattgcact ccagcctggg caacaagcga aactctgtct     2160

caaaaaaaaa gaaaagacag tagcatatgt tcatgtcaag cacctctcat cacagtcgag     2220

ttccaaggaa aaattccagt gttttctgca ttgggtgctg tgtcatctga aatcggcaca     2280

ttccatggag gaaggagtcc tgctttgttg catgtatcct agggtttaat gttggtaaat     2340

gagtcactct agcatttgta gaaggctccc tgagactcct gcagcagtcg accaagccca     2400

aggacataat tgaatctgga gagtcctggg gccttgtttt gaaaaagact tgaaatacac     2460

ataggaagaa aggcataaaa ataaatgttc acttgtctct gctgtgagta tgtgttccaa     2520

cttttcagtg atggctttga gaattctcaa acttgactgg ctctaagtgt atctggtggc     2580

ttttgtatcg taacctgaaa ctggcttagt actttttcct aaaagctcag gatttgagaa     2640

tgaggacccc ttcgccagga aaacatgtat acactcaaaa ttttgcttgc agttctaggg     2700

tgtttagacc cttctcagat acctgtgcat cttatgggtt ttgtttttct ctttgagaca     2760

gtctcaccct gttgcccagg ctggagcgca gtggcatgat ctcagctcat tgcagcctcc     2820

acctcctggg ttcaagtgat tctgcctcag ccccttgatc agctgggatt acatgcatgt     2880

accaccacac ccagctaatt cttgtatttt tagtagagat ggagacagag tttcaccatg     2940

taggccaggc tagtctcaaa ctcctgacct caagtgatcc acaagcctgg gcctcccaaa     3000

gtgctgggat tacaggcatg agcaactgcg cccagctctt gtgtacctta tgtgaggaag     3060

tcctgctcaa tcaggatcgg tcacgcaggc cctgatcttg ctactctggt tccatgtcct     3120

atggaagacc aaagtttacc aagatagatt tttcccttca tagtggcaga tagtgttaac     3180

ccctgcacca tctgtaactc agaaatcccc accatttctt cccctgggct tcagaataga     3240

attgcctggt ttctctgatg atcagcatgg ttccttaaaa cccaaatcag caaggaatga     3300

acaattttgt ttggcatgga tgaaattagc actgtttggc tcgttaggcc ccaggcaggc     3360

aggcacctta attttttcct tgcatattct agtcttcaga agcattgcct tttgtcctac     3420

tggtagtgac atagaccaat aacagggcat ctggggattt taatcctgaa aacagtgagt     3480

ctgatactgc ttgtgttttt catcagtgtc caccccaagt gggtcttcct gctattctct     3540

tcacttagtt gcccctcact tgccatctga gcaattggca aggatgtgcc aggcctaggt     3600

taaacttgga aacatgcttg accattctat tccctggtcc tttaagatca gtttggctgc     3660

aattttggct ccttggaccc tcaagcatag ctggtaaatc aagttagaga tgtaactgcc     3720

ttaaaacatg ccagcttagg ctgggcacgg tggctcacac ctgtaatctc aacacttcag     3780

gaggctgagg caggcagatc acttgaggtc aggagttcga gaccagcctg accaacatgg     3840

agaaattctg tccctactga aaatacaaaa ttagccggat gtggtggtgc atgcctgtaa     3900

tcccagctac ttgggaggct gaggcaagag aattgcttga acccagggag gcagaggttg     3960

cagtgagccg agatcacacc attgcactcc accttgggca acaaaagcaa aactctgtct     4020

caaaaaaaaa aaaaaaaaaa gtgccagcgt atgaggtaat tagattggtt ctctccagag     4080

gtaacctgcc aagaagagat gctatagatg ttactcctat actgtaaaac attgtgaaat     4140

cagattactt taaaatgatg tattacaaag ttatgcaaaa aagcagttgt gactatggaa     4200

gcccaaggct tatatcccag ctctgtctta cactaaatat gggtacagtg tttccactct     4260

gtccataaaa tgggagctaa tattctccaa cctgtgtgcc tgacatgatg gttaaaggga     4320

ttaaacaaaa caatagtttg taatttattc tgtcagagca aactgctggt aaataaaagg     4380

gactaagttg acgaaaaata aattttaaaa aacctaataa aacaagtttg taatttataa     4440

ttgtatacaa ataaaagatg ttacaaaaat tgcgca                               4476


<210> 3806
<211> 2117
<212> DNA
<213> Homo sapiens

<400> 3806
gcggagactg cggggcgggc catggcggcg aacctgagcc ggaacgggcc agcgctgcaa       60

gaggcctacg tgcgggtggt caccgagaag tccccgaccg actgggctct ctttacctat      120

gaaggcaaca gcaatgacat ccgcgtggct ggcacagggg agggtggcct ggaggagatg      180

gtggaggagc tcaacagcgg gaaggtgatg tacgccttct gcagagtgaa ggaccccaac      240

tctggactgc ccaaatttgt cctcatcaac tggacaggcg agggcgtgaa cgatgtgcgg      300

aagggagcct gtgccagcca cgtcagcacc atggccagct tcctgaaggg ggcccatgtg      360

accatcaacg cacgggccga ggaggatgtg gagcctgagt gcatcatgga gaaggtggcc      420

aaggcttcag gtgccaacta cagctttcac aaggagagtg gccgcttcca ggacgtggga      480

ccccaggccc cagtgggctc tgtgtaccag aagaccaatg ccgtgtctga gattaaaagg      540

gttggtaaag acagcttctg ggccaaagca gagaaggagg aggagaaccg tcggctggag      600

gaaaagcggc gggccgagga ggcacagcgg cagctggagc aggagcgccg ggagcgtgag      660

ctgcgtgagg ctgcacgccg ggagcagcgc tatcaggagc agggtggcga ggccagcccc      720

cagagcagga cgtgggagca gcagcaagaa gtggtttcaa ggaaccgaaa tgagcaggag      780

tctgccgtgc acccgaggga gattttcaag cagaaggaga gggccatgtc caccacctcc      840

atctccagtc ctcagcctgg caagctgagg agccccttcc tgcagaagca gctcacccaa      900

ccagagaccc actttggcag agagccagct gctgccatct caaggcccag ggcagatctc      960

cctgctgagg agccggcgcc cagcactcct ccatgtctgg tgcaggcaga agaggaggct     1020

gtgtatgagg aacctccaga gcaggagacc ttctacgagc agcccccact ggtgcagcag     1080

caaggtgctg gctctgagca cattgaccac cacattcagg gccaggggct cagtgggcaa     1140

gggctctgtg cccgtgccct gtacgactac caggcagccg acgacacaga gatctccttt     1200

gaccccgaga acctcatcac gggcatcgag gtgatcgacg aaggctggtg gcgtggctat     1260

gggccggatg gccattttgg catgttccct gccaactacg tggagctcat tgagtgaggc     1320

tgagggcaca tcttgccctt cccctctcag acatggcttc cttattgctg gaagaggagg     1380

cctgggagtt gacattcagc actcttccag gaataggacc cccagtgagg atgaggcctc     1440

agggctccct ccggcttggc agactcagcc tgtcacccca aatgcagcaa tggcctggtg     1500

attcccacac atccttcctg catcccccga ccctcccaga cagcttggct cttgcccctg     1560

acaggatact gagccaagcc ctgcctgtgg ccaagccctg agtggccact gccaagctgc     1620

ggggaagggt cctgagcagg ggcatctggg aggctctggc tgccttctgc atttatttgc     1680

cttttttctt tttctcttgc ttctaagggg tggtggccac cactgtttag aatgaccctt     1740

gggaacagtg aacgtagaga attgttttta gcagagtttg tgaccaaagt cagagtggat     1800

catggtggtt tggcagcagg gaatttgtct tgttggagcc tgctctgtgc tccccactcc     1860

atttctctgt ccctctgcct gggctatggg aagtggggat gcagatggcc aagctcccac     1920

cctgggtatt caaaaacggc agacacaaca tgttcctcca cgcggctcac tcgatgcctg     1980

caggccccag tgtgtgcctc aactgattct gacttcagga aaagtaacac agagtggcct     2040

tggcctgttg tcttccccta ttttctgtcc cagctcatcc gtgtctctga agaacaaata     2100

tgcttttgga ccacgaa                                                    2117


<210> 3807
<211> 4294
<212> DNA
<213> Homo sapiens

<400> 3807
gggcaccaga gtgccgagcc caggacgccc ccggcccagg cccttggggt ggacaagtcc       60

ttcacttctc gccggagtgt gtggaggagc gatgggcaga accagcactt ccctcaggca      120

ctagacctgt cacgagtgaa cttagttccc tcctatactc cttcactcta ccctaagaac      180

acagatctat ttgagatgat tgagaagatg cagggaagca ggatggatga acaacgctgc      240

tccttcccgc cgcccctcaa aacagaggag gactacattc catacccgag cgtgcacgag      300

gtcttggggc gagaaggacc cttccccctc atcctgctgc cccagtttgg gggctactgg      360

attgagggca ccaaccacga aatcaccagc atccccgaga cagagccact gcagtcgccc      420

acaaccaagg tgaagctcga gtgcaacccc acagcccgca tctaccggaa gcactttctc      480

ggcaaggagc atttcaatta ctactcactg gacgctgccc tcggccacct tgtcttctca      540

ctcaagtacg atgtcatcgg ggaccaagag cacctgcggc tgctgctcag gaccaagtgc      600

cggacatacc atgatgtcat ccccatctcc tgcctcaccg agttccctaa tgttgtccag      660

atggcaaagt tggtgtgtga agacgtcaat gtggatcggt tctatcctgt gctctacccc      720

aaggcttccc ggctcatcgt cacctttgac gagcatgtca tcagcaataa cttcaagttt      780

ggcgtcattt atcagaagct tgggcagacc tccgaggaag aactcttcag caccaatgag      840

gaaagtcccg ctttcgtgga gttccttgaa tttcttggcc agaaggtcaa actgcaggac      900

tttaaggggt tccgaggagg cctggacgtg acccacgggc agacggggac cgaatctgtg      960

tactgcaact tccgcaacaa ggagatcatg tttcacgtgt ccaccaagct gccatacacg     1020

gaaggggacg cccagcagtt gcagcggaag cggcacatcg ggaacgacat cgtggctgtg     1080

gtcttccagg atgagaacac tcctttcgtg cccgacatga tcgcgtccaa cttcctgcat     1140

gcctacgtcg tggtgcaggc tgagggcggg ggccctgatg gccccctcta caaggtctct     1200

gtcactgcaa gagatgatgt gcccttcttt ggaccccccc tcccggaccc cgctgtgttc     1260

aggaaggggc ctgagttcca ggaatttttg ctgacaaagc tgatcaatgc tgaatatgcc     1320

tgctacaagg cagagaagtt tgccaaactg gaggagcgga cgcgggccgc cctcctggag     1380

acgctctatg aggaactaca catccacagc cagtccatga tgggcttggg cggcgacgag     1440

gacaagatgg agaatggcag tgggggcggc ggcttctttg agtctttcaa gcgggtcatc     1500

cggagccgca gccagtccat ggatgccatg gggctgagca acaagaagcc caacaccgtg     1560

tccaccagcc acagcgggag cttcgcgccc aacaaccccg acctggccaa ggcggctgga     1620

atatcattgc ttattcctgg gaaaagtgcg agtagattcg gacgccgggg cagtgccata     1680

ggcataggaa ccgtggaaga ggttgtcgtc cgcggggccg ccggctctgg aggctgcctg     1740

cacgcgctgt tctctgctcg ctctcaggac ggaggccata ttggggacgt tgcccctctg     1800

cccccgggac aggccccagg gcgtgcggga tggagtggcg gcagctccga tggcactcag     1860

cacctgcttt ggggcctggt acctgtgcca gagccagtgc ccctcaccag gggcttctgg     1920

ccctgccttg gcccctggga ccctggccca gtccctgcca ggatccggta cccaaaggcc     1980

ctacacccag ccgcacgtcc cccaatatcg ccggtctgca tggagcgcca tccctctcct     2040

ctgccctgac tcctcctccc cgccacgaag tgacctgggg tcctacccct tcctgcctcc     2100

agagaagctg ggggcgggct tctggggcct ggggcatccc agcacagtgt gtgggaagct     2160

gggggagtct tccagctgct gggccagaac ctcccccagc caatttggag gttccgggga     2220

ggggccctag ctggcacggg gtgggacttg ggttgctaca ctgccctctg accactgccc     2280

ttaggctgca gatcccacag agccctgggg ggcggggagc ggtagccatt ctgaggactc     2340

ggcctcctcc caccctagcc ccctcaggat gctgtcctaa tcctgggcca gtattgacgt     2400

gcagtcctgc cgtgtgagct cgggagagcc ccttgccctc ctggggactg tttccctttc     2460

gtaaactggg aggctgtctc tgggaatgga tatcttctct cgttctttct tgctcatcaa     2520

ctctgcttca gggcctgggg cagcaggatc cccagagggg atgtgggggg ggcactgggg     2580

ctcccaggta aggtggcact gagttggggc ctctccccac agtcactgat tgtccctggg     2640

aagagcccca cgaggaagaa gtcgggcccg ttcggctccc gccgcagcag cgccattggc     2700

atcgagaaca tacaggaggt gcaggagaag agggagagcc ctccggctgg tcagaagacc     2760

ccagacagcg ggcacgtctc acaggagccc aagtcggaga actcatccac tcagagctcc     2820

ccagagatgc ccacgaccaa gaacagagcg gagaccgcag cgcagagagc agaggcgctc     2880

aaggacttct cccgctcctc gtccagtgcc agcagcttcg ccagcgtggt ggaggagacg     2940

gagggtgtgg acggagagga cacaggcctg gagagcgtgt catcctcagg aacaccccac     3000

aagcgggact ccttcatcta tagcacgtgg ctggaggaca gtgtcagcac cactagtggg     3060

ggcagctccc cagtgaggtg gctccctcct gcccccctcc ccaggcccct ctcgatcacc     3120

ccacccagac gccggcaagt tgggggaccc tgcgtgtccc gagatcaaga tccagctgga     3180

agcatctgag cagcacatgc cccagctggg ctgttagccg ggccaccccc tctgaaggtg     3240

aaactgagca gatgaggcca cagaagcaca aggggaaggt gccgtgtcaa gcccaggcag     3300

acgagacctc tgccctgaag accaacacca gcccgtgggc tgccccctgc ctccccaccc     3360

tccccatggc ccacccatct gggctgtctc tgcagggcag agccgtccag acctgggatc     3420

agggaagctg ctggcatcgt ccccaccccc agcctggggg tctgggctgg ggcagggatt     3480

gctcagtgga agcaggactg ggggtctggc ttgccccctc cctgggcctc catcacccct     3540

gagcatccct ctggactcag agggaacaag gtgggagaga gagtttgaga cagctccgtg     3600

tggagagctt agcccctgga ggcagcacaa ggaggatgtg atatgtgggg gagtgagcac     3660

tgggttggga gccgggtcct ggtttccaat ttgggttctg ctgtgtgact ctgggcaagt     3720

cactctccct ctctgggcat gtctgctaca aatggacaag attatttcag aggtcactga     3780

agactgtgat tacatgcacc tgccttagaa ggtaggattt tcttcccagg gacctcctat     3840

caccctaccc tgcttcttga ggtccctgga gccccaggtg ggctgagggg cagggagccg     3900

gctgtgccca gtatgcctcc tggaccctcc agttctgcca caggtctgcc gatgccctgt     3960

ccactgccta cacatgacag acaagtaacc ccctcatggg ggatggggac ctacctggct     4020

cctcagccag cacccagctt aacccctgcc atcccatgct gggccctcca ggccaagagt     4080

ctcagctggc cgagagtcca ggccttgcct cccccgaccg ccatggaggg ggcagcccgg     4140

cacagctgct gggagccctt gtgtgtctgg tcacactttt taggcgtcac gccaaaggcc     4200

agcctcctgg ccccaatacc cattttggaa gcccctgtgg ccgtgtggat gtcggtaaca     4260

gttgtataaa ataaattcta tttatcgcta ttgt                                 4294


<210> 3808
<211> 2552
<212> DNA
<213> Homo sapiens

<400> 3808
cgtctatttt cctacgactc cagctggcct tgaacatggg aaacacgagc ttcaatgagg       60

tcatggaggc ccagctaccc tcacacggcg gccctaaacc ctcagctgag agtgacatgg      120

gcacccgcag ggactacatt atggccaagt atgtggagca taggtttgca cgccggtgca      180

cacctgagcc tcagcgactc tggacagcca tttgcaacag ggacctcctg tcggtactgg      240

aggcctttgc caatgggcag gactttggac agccgctgcc agggcctgat gcacaggcac      300

ctgaagaact cgtcttgcat ttggctgtca aagtcgccaa ccaggcttcc ctgcctctgg      360

tggatttcat catccagaac ggtggtcacc tggatgccaa ggctgctgac gggaacacgg      420

ctctgcacta cgcagcactc tacaaccagc ccgactgcct caagctgctg ctgaagggga      480

gagctttggt tggcacagta aatgaagcag gcgagacagc tctggacata gccaggaaga      540

agcaccacaa ggagtgtgag gagctgctgg agcaggccca ggcggggacc tttgccttcc      600

ctctacatgt ggactactcc tgggtaattt ccacagagcc tggctctgac agtgaggagg      660

atgaggaaga gaagcgctgc ttgctgaagc tcccggccca ggctcactgg gccagtggga      720

ggctggacat cagcaacaag acctatgaga ctgtcgccag cctgggagca gccacccctc      780

agggcgagag tgaggactgt cccccgccct tgccagtcaa aaactcttct cggactttgg      840

tccaagggtg tgcaagacat gccagtggag atcgttctga agtctccagc ctgagttcag      900

aggcccctga gacccctgag agcctgggca gtccagcctc ctcctccagt ctgatgagcc      960

ccttggaacc tggggatccc agccaagccc cacccaactc tgaagagggc ctccgagagc     1020

ccccaggcac ctccagaccc agcctgacat ccgggaccac cccttcggag atgtacctcc     1080

ccgtcagatt cagctccgag agcactcgct cctatcggcg gggggcgcgg agccctgaag     1140

atggtccctc agccaggcag cctctgccca gaaggaacgt gccggttggc atcactgaag     1200

gagatggctc aaggactggg agtctcccag caagttctgt gcaacttttg caagactagc     1260

tccttgctgg cccccacatg ccccatgcta ggccccaatg ttcagagctg ggacttgagc     1320

tcacaaaact ggggagctga gacatttgtt ctcttggatc tcactctctc tgtcccttgt     1380

gcctctgtag ctggccttct tcctgccaca ggccatgcct ctaccaagga cacatggcct     1440

ttccctgtta ggactgatgg cggttctttc ctatctcatt acccgctagg ggcctgggag     1500

ccctgtggct ggatctgagt gctcctgagc tggcttcagc tgcagaactc tcagtccctc     1560

atcagatcga gactctattt cccccgtcag tctgggggct tcacaagggc aggagagccc     1620

tccatcactg acttccagat cagggaccct gccaagtagg gactgtcttc tcagccagcc     1680

atttattagt ctaatattcc ttcactaaat tccaactcta tgtctggacc tgtgttaggc     1740

acttcagata ccacacgagt aagacaaggg ccctgcaggg gtggtccttt ggtggaaagc     1800

tggtcttaag ggttgggctt gggaataggc agggtcagat tccagggcat ggctctggac     1860

tcagctggtt tatacctata tgaccattac aattgtctac agatcacatc cattctggct     1920

ggtcaacatg catgctgtac tggctgttaa ataaaaatat tctgaatgtc actccttttg     1980

agggacagca cagccttccc taggcattct cctatattcc ccagccaaat tgtagagtca     2040

gatgcaccca catttgcctg tgtccttgat ttagcaggaa ggaaaggaat agtcagggtt     2100

gatggatgcc cacttctctt ctctttctct tggtcaactc aggagccttt tagtctgagg     2160

gaatggagag gcaaagaaag aagggagagt aatagaattg ggagggcaga gacttaaggg     2220

ttctgcttcc cagccctaga aattctatca ttgctcagcc ccaatgagaa agcagataca     2280

cctaagccat catcaaccac taacatctca acttgccagt tgctgggtgc tgggccctgg     2340

caggaatggg ccaagccaag caggggagac tagagagcac caatggccaa cacagctgcc     2400

tggctgggga ggctgtgctg tttcccctgg agacctgact ggtctgtggt tcccacagga     2460

acagggttgt cttttgagcc cccagtgtct ggtttcattc atctcagact tgttatttca     2520

ctcatctcta ataaaggatt ggggggtcag tt                                   2552


<210> 3809
<211> 813
<212> DNA
<213> Homo sapiens

<400> 3809
atggcgatgg agatgaggct tccagtggct cgcaagcctc ttagcgagag actgggccgc       60

gacactaaga aacatctagt ggtgccgggg gatacaatca ctacggacac aggattcatg      120

cggggccatg gaacgtatat gggagaagag aagctcattg catctgttgc tggctctgtg      180

gagagagtaa acaagttgat ctgtgtgaaa gctttgaaaa ccagatacat tggtgaagta      240

ggagacatcg tagtgggacg aatcacagag gttcaacaga agaggtggaa ggtggagacc      300

aactccaggc tggattcggt cttgctgctc tcgtccatga accttcctgg aggagagctg      360

aggagaagat ctgcagaaga tgagcttgca atgagaggtt tcttacagga aggggacctt      420

atcagtctag gtcagggggt tttggtccag gtttccccct ccctggtgaa acggcagaag      480

acccactttc atgatttgcc atgtggtgcc tcagtgattc tcggtaacaa cggcttcatc      540

tggatttacc caacacctga gcacaaagaa gaggaagcag ggggcttcat tgcaaacctg      600

gagcctgtct ctcttgctga tcgagaggtg atatcccggc ttcggaactg catcatctcg      660

ctggtaactc agaggatgat gctgtatgat accagcatcc tgtactgcta tgaagcatcc      720

cttccacatc agatcaaaga catcttaaag ccagaaataa tggaggagat tgtgatggaa      780

acacgccaga ggcttttgga acaggaggga taa                                   813


<210> 3810
<211> 542
<212> DNA
<213> Homo sapiens

<400> 3810
atgtatgtcc tcacaatgca ggaggtgaaa tgtgtatgtc atgtgtccaa attgtaagat       60

acttgctata ctttcccagc aacatctaga ctgctgtttg accaaacaac ggggctccaa      120

cagcctagcc aagtgaaaca taaaactaac catcacagta tccttgtcaa aaatcagtct      180

gacaacacat cagaggaaag aaattcctaa gggaacactg ctcagaaagt actgcagcat      240

gtcttcaaat gcctgaggat caagttggaa aactagaagc aacagaaaac acaataagcg      300

caatggcggc ggccgcggcg gagcagcaac agttctacct gctcctggga aacctgctca      360

gccccgacaa tgtggtccgg aaacaggcag aggaaaccta tgagaatatc ccaggccagt      420

caaagatcac attcctctta caagccatca gaaatacaac agctgctgaa gaggctagac      480

aaatggccgc cgttctccta agacgtctct tgtcctctgc atttgatgaa gtctatccag      540

ca                                                                     542


<210> 3811
<211> 569
<212> DNA
<213> Homo sapiens

<400> 3811
atgcgcgctg cagcccgcgg cccccgagag ccgcgctttt gtaagagctg gccccttaca       60

tatggaaatg acgctcacgc gggtccccat tcgcgtcctt ttgaaggacg cccgcccgga      120

accgctgcgc cggctgcgaa gtattgtccc gtttctccag ccctaacaaa gcgtcctcct      180

tcgctttgca gagcgctgga ggcgggctgc cggctgtgcg ggcgctccgg agagaccgac      240

agaaggtgag cactgtgggc tatgggatgg atgaggtgga gcaggaccag catgaggccc      300

gactcaagga gctgtttgac agttttgaca cgacgggcac agggtccctg gggcaggagg      360

aactcaccga cctttgccac atgttgagct tggaggaggt ggccccagtg ctgcagcaga      420

cattacttca ggacaacctc ttgggcaggg tacattttga ccaatttaaa gaagcattaa      480

tactcatctt gtccagaact ctgtcaaatg aagaacactt tcaagaacca gactgctcac      540

tagaagctca gcccaaatat gttagaggt                                        569


<210> 3812
<211> 1186
<212> DNA
<213> Homo sapiens

<400> 3812
attcgcctcc atggcccact cgccggtggc tgtccaagtg cctgggatgc agaataacat       60

agctgatcca gaagaactgt tcacaaaatt agagcgcatt gggaaaggct catttgggga      120

agttttcaaa ggaattgata accgtaccca gcaagtcgtt gctattaaaa tcatagacct      180

tgaggaagcc gaagatgaaa tagaagacat tcagcaagaa ataactgtct tgagtcaatg      240

tgacagctca tatgtaacaa aatactatgg gtcatattta aaggggtcta aattatggat      300

aataatggaa tacctgggcg gtggttcagc actggatctt cttcgagctg gtccatttga      360

tgagttccag attgctacca tgctaaagga aattttaaaa ggtctggact atctgcattc      420

agaaaagaaa attcaccgag acataaaagc tgccaatgtc ttgctctcag aacaaggaga      480

tgttaaactt gctgattttg gagttgctgg tcagctgaca gatacacaga ttaaaagaaa      540

tacctttgtg ggaactccat tttggatggc tcctgaagtt attcaacagt cagcttatga      600

ctcaaaacgt cctacagcaa aagaacttct gaaacacaaa ttcattgtaa aaaattcaaa      660

gaagacttct tatctgactg aactgataga tcgttttaag agatggaagg cagaaggaca      720

cagtgatgat gaatctgatt ccgagggctc tgattcggaa tctaccagca gggaaaacaa      780

tactcatcct gaatggagct ttaccaccgt acgaaagaag cctgatccaa agaaagtaca      840

gaatggggca gagcaagatc ttgtgcaaac cctgagttgt ttgtctatga taatcacacc      900

tgcatttgct gaacttaaac agcaggacga gaataacgct agcaggaatc aggcgattga      960

agaactcgag aaaagtattg ctgtggctga agccgcctgt cccggcatca cagataaaat     1020

ggtgaagaaa ctaattgaaa aatttcaaaa gtgttcagca gacgaatccc cctaagaaac     1080

ttattattgg cttctgtttc atatggaccc agagagcccc accaaaccta cgtcaagatt     1140

aacaatgctt aacccatgag ctccatgtgc cttttggatc tttgca                    1186


<210> 3813
<211> 708
<212> DNA
<213> Homo sapiens

<400> 3813
gggcccgaga ccccgcctct cggcgagccc gccctcttct gaagaggcgt ttctggacca       60

ctgagccccg cctcccactg cgccattttc gagtgaagga cccggagccg aaacaccggt      120

aggagcgggg aggtgggtac tacacaaccg tctccagcct tggtctgagt ggactgtcct      180

gcagcgacca tgccccgtaa aggcacccag ccctccactg cccggcgcag agaggaaggg      240

ccgccgccgc cgtcccctga cggcgccagc agcgacgcgg agcctgagcc gccgtccggc      300

cgcacggaga gcccagccac cgccgcagag actgcaagtg aggaacttga taatagaagt      360

ttagaagaga ttttgaacag cattcctcct cccccgcctc cagcaatgac caatgaagct      420

ggagctcctc ggcttatgat aactcatatt gtaaaccaga acttcaaatc ctatgctggg      480

gagaaaattc tgggaccttt ccataagcgc ttttcctgta ttatcgggcc aaatggcagt      540

ggcaaatcca atgttattga ttctatgctt tttgtgtttg gctatcgagc acaaaaaata      600

agatctaaaa aactctcagt attaatacat aattctgatg aacacaagga cattcagagt      660

tgtacagtag aagttcattt tcaaaagata attgataagg aaggggat                   708


<210> 3814
<211> 795
<212> DNA
<213> Homo sapiens

<400> 3814
gccgcgcgct gcagctcgag ttcgggccgc gggggaggct ttggagcggc gccggcggtg       60

gctcggccgg ctcagcccct ccgccccgcg tccccgccgt gcgcggcctt ccctgaggcg      120

ggcgtccgcg tgggtccggg atcgcgtggc cgggcggccg ggcgcactcc cgggattcca      180

ggcttccggg gtggcgggcg aggcccagaa agcaccaggc cacccggccg cgccggcacc      240

cgccgcgtcc tgcttgacag aggctgatgg acgtgtattt ctccacgctt tccgcttggc      300

cctcatccag cttcagattt cttccatcaa atcagataac gtcactcgcg cttgtagctt      360

catccgggag gcagcaacgc aaggagccaa aatagtttct ttgccggaat gctttaattc      420

tccatatgga gcgaaatatt ttcctgaata tgcagagaaa attcctggtg aatccacaca      480

gaagctttct gaagtagcaa aggaatgcag catatatctc attggaggct ctatccctga      540

agaggatgct gggaaattat ataacacctg tgctgtgttt gggcctgatg gaactttact      600

agcaaagtat agaaagatcc atctgtttga cattgatgtt cctggaaaaa ttacatttca      660

agaatctaaa acattgagtc cgggtgatag tttctccaca tttgatactc cttactgcag      720

agtgggtctg ggcatctgct acgacatgcg gtttgcagag cttgcacaaa tctacgcaca      780

gagaggtgag gcagt                                                       795


<210> 3815
<211> 576
<212> DNA
<213> Homo sapiens

<400> 3815
gtttagctcc tgggaaatga tgagattgat gattctttct cctggaaaac ctttcatcac       60

agagattcat ctcagctgaa cactgaacag cttagcagag gccttctgtc ctctcttatc      120

tcatcaccag aggattttcc tcccttcttt tcatccttgc tgtgatctat gcaaacagct      180

actggccaaa gaagagctta gcagaggggg aggactccaa gtctgagctt tgataaattc      240

tggaaatgag gggattgtta tctggaaaag gcgtacattt gtattctcta gcattaaagg      300

gcagtattta aagtcagttg gcaagcagtg gaataagatt tttgtaaaga aaccttgtgc      360

agcatggatt ctctaccaga tgaatttttt gtgaggcatc ctgctgtgga ggatcagagg      420

aaggaagaaa ctgagaataa gctagaaaaa tcatctggtc aactgaacaa acaggaaaat      480

gacataccta ctgatcttgt ccctgttaac ctactattag aagtgaagaa gttattaaat      540

gcaattaata ctctaccaaa aggtgtggtt cctcac                                576


<210> 3816
<211> 3022
<212> DNA
<213> Homo sapiens

<400> 3816
gttttgtttg ttgtggtttt gatgtttttt ttcctttcag ctaaaggagc agcccagtgg       60

ttttcaagaa gtgctaaagt gcactgactg tctcatgatg actggtgcct cagggagggt      120

catgattcct ggatacagga tcgacctgat cctggatgtc acttcaagca gtcagatcgt      180

ggggaaaagc cttgtctaat ggctagcctt cctcaaaagt ctgatgctag tcatctcgga      240

aggcctcaga aaaagcctta aagcttcatt tacctcttaa ttctcctttg cctggaagtg      300

aattgaccaa ggaacctttt cgttgggatc agagactctt tgcattagtg ttgcggttgc      360

ctggcaccat gtcagtagaa tcagaacagt tgacaggtgt gcctttagat gactctgcaa      420

tcacaccaat gtgtgaagtg acaggcggcc gttcatattc tgtgtgttct ccaagaatgc      480

ttaatcagtg tctggagtcc ttggtgcaga aagtacaaag tggggtggta ataaactttg      540

aaaaagcagg accagatcct tcccctgtag aagatgggca gccagatata tcaaggcctt      600

ttggatctca gccttggcat agctgtcaca aactcatata tgtcagacca aatcctaaaa      660

ctggggttcc tataggtcat tggcctgttc cagagtcttt ttggccagat caaaattcgc      720

caacactacc acctcgtaca tctcatcctg tagtgaagtt ttcctgtaca gactgtgaac      780

caatggttat tgataaactt ccttttgaca aatatgagtt ggaaccttca ccactgactc      840

aatttatcct ggaaaggaaa tctcctcaaa catgttggca ggtgtacgtg agcaatagtg      900

caaaatacag tgaacttggt catccttttg gttacttgaa agccagtaca gcactgaact      960

gtgtcaactt atttgtgatg ccttacaatt atccagtcct tcttcccctc ttagatgact     1020

tgtttaaagt gcataaagca aaaccaacat tgaagtggag acagtcattt gaaagttatt     1080

tgaagacaat gcctccctac tatcttgggc ccttgaagaa agctgttagg atgatgggag     1140

cacctaacct aatagcagac agtatggaat atggacttag ttacagtgtc atttcatacc     1200

tcaaaaaact gagtcaacag gccaaaatag aatctgatcg agtcattgga tctgtaggca     1260

aaaaagtagt acaggagact ggaataaaag tccggagccg atcacatggt ttatcaatgg     1320

catataggaa agattttcaa caactcctcc agggaatttc agaggatgtc cctcacagac     1380

tgctagacct taatatgaag gaatacactg ggttccaagt tgctttgctg aataaggatt     1440

tgaagccaca gacatttaga aatgcttatg acataccaag acgaaatctt ttggatcact     1500

taacaagaat gagatctaat cttttgaaga gcactcgcag atttctgaaa ggacaggacg     1560

aagatcaagt gcacagtgtt cctatagcac aaatggggaa ctaccaggaa tacctcaagc     1620

aagtaccttc tccactaaga gaacttgatc ctgatcagcc acgaaggttg catacatttg     1680

gcaacccctt taagctggat aagaagggta tgatgataga tgaagcagat gaatttgtgg     1740

ctggacctca aaataaacat aaacgacccg gagaaccaaa tatgcaaggg atccctaaaa     1800

gacgtcggtg tatgtctcca ctactaagag gcagacagca gaatcctgtt gtaaacaatc     1860

atattggggg aaaaggacca cctgcaccta caactcaagc acagccagat cttattaaac     1920

ctcttcctct tcataaaatt tcagaaacca ctaatgattc gataatacat gatgtggttg     1980

aaaatcatgt tgcagaccaa ctttcatcag acattacacc aaatgctatg gatacggaat     2040

tttcagcatc ttctccagcc agtttactgg aacggccaac caatcatatg gaggctcttg     2100

gtcatgacca tttaggaacc aatgacctca ctgttggtgg atttttagaa aatcatgagg     2160

agccaagaga taaagaacaa tgtgctgaag agaacatacc agcatcttca ctcaacaaag     2220

gaaagaaatt gatgcattgc agaagccatg aagaggtcaa tactgaacta aaagcacaaa     2280

taatgaaaga gatccgaaag ccaggaagaa aatatgaaag aatcttcact ttactgaagc     2340

atgtgcaagg cagtttacaa acaagactaa tatttttaca aaatgtcatt aaagaagcat     2400

caaggtttaa aaaacgaatg ctaatagaac aactggagaa cttcttggat gaaattcatc     2460

gaagagccaa tcagatcaac catattaata gcaattaaaa gaaaatagaa tgtggccact     2520

tatttcacta tcttcttcaa atacaaagta aatacaagac tgttgtgatc ttgcattcat     2580

tttctgacat gcattgttgg ctatttgaaa tactaaaagc aaatctacag atcctttttc     2640

catcatttta cagtgacctt ttcttcattt tggtttattt ttgtaatgtg aaaagtatca     2700

ctctaaaaaa catttttaat ttaacaaact aaaaatattc ctccaaatct cttgcttgtc     2760

attgactctt gcgtgtcaat ttccctcagg ttctattttc ttaaaccaac ctttaaaatt     2820

gtcacctctg ttaaggttga actttgccaa aaaaaaaaga agttactttg taatttttgg     2880

ggaaaaaagc acatacatta aaactaggta atgttttgta tatacagtta ttttggatat     2940

attattgtaa gttgtacaaa tgtattttga agaatattta agaaaagcac ttttgttatt     3000

ccatcaataa atgctctatt tt                                              3022


<210> 3817
<211> 561
<212> DNA
<213> Homo sapiens

<400> 3817
gatgccatcc ttctcaaaag acttattgac agtgccaaag ctcggtactg gacacaacga       60

gggacctggg tctacgataa cgcgcttttg ctcctcctga agtgtctttg gtccaacgtt      120

gttccaggtt tgtcaccgtt tctctccggc cggtcagggc aagagccaga gtgtaccatg      180

gcttccagta acactgtgtt gatgcggttg gtagcctccg catattctat tgctcaaaag      240

gcaggaatga tagtcagacg tgttattgct gaaggagacc tgggtattgt ggagaagacc      300

tgtgcaacag acctgcagac caaagctgac cgattggcac agatgagcat atgttcttca      360

ttggcccgga aattccccaa actcacaatt ataggggaag aggatctgcc ttctgaggaa      420

gtggatcaag agctgattga agacagtcag tgggaagaaa tactgaagca accatgccca      480

tcgcagtaca gtgctattaa agaagaagat ctcgtggtct gggttgatcc tctggatgga      540

accaaggaat ataccgaagg t                                                561


<210> 3818
<211> 942
<212> DNA
<213> Homo sapiens

<400> 3818
agttgacgcg ggggcgggga gtcagcgagg gcgagcctac tggagtttgc cgggggtggg       60

aagaaggtgg gcctcgagca aagccgctag aggtggggtg cgggtggtcg gcctcaggcg      120

agccccgggg cacagcccgg ggcgggaggc ggagcttggc ggccgagatc tccgcgctgc      180

agttagcccc gccgagcgcc aggagctgcg gactgccact ctccgcccct acctgagtgc      240

cgtgcgggcc acattgcagg ctgccctctg cctggagaac ttctcctccc aggttgtgga      300

acgacacaac aagccggaag tggaagtcag gagtagcaaa gagctcctgt tacaacctgt      360

gaccatcagc aggaatgaga aggaaaaggt tctgattgag ggctccatca actctgtccg      420

ggtcagcatt gctgtgaaac aggctgatga gatcgagaag attttgtgcc acaagttcat      480

gcgcttcatg atgatgcgag cagagaactt ctttatcctt cgaaggaagc ctgtggaggg      540

gtatgatatc agctttctga tcaccaactt ccacacagag cagatgtaca aacacaagtt      600

ggtggacttt gtgatccact tcatggagga gattgacaag gagatcagtg agatgaagct      660

gtcagtcaat gcccgtgccc gcattgtggc tgaagagttc cttaagaatt tttaaaccat      720

ctggctggat ctcgtggcct tccccctcag actacccatg tctccacgaa ggcgtcctgg      780

agtcactccc cgagcagcgc ggcggcggca gggagttggg ttggggtggg catttgatgc      840

gggaggtggg tggtgtgctt gctagctggg caagaaagca gcagtggacc tgccccaagg      900

ccacacgtgc ctggtcaggc tggcttctga tgttcagtcc cc                         942


<210> 3819
<211> 508
<212> DNA
<213> Homo sapiens

<400> 3819
ggattgatcc tgctggccgc agccacccac gtggtggaag cccggccctg caggctggag       60

aggatttgat tagactacgc gtttcgactt gcagggtgtt taatcgtcgc caagcgggac      120

ttactgcaag ctatcaaatc tgaggtctta ttttgttgag tcgaaagtga aattttcctt      180

tggccaacgt gacagggctt tgtttggtgg taaaaagggt tactagacac ccctcattcc      240

actgccactg gagggcgcat ttctcagctc ttgctcttca aacctgctga aaggaattcc      300

tagatctaaa caccagcatt tgacattgtg cagcaaagaa atggttatgg agaagcccag      360

tccgctgctt gtagggcggg agtttgtgag gcaatattat actttgctga ataaagctcc      420

ggaatattta cacaggtttt atggcaggaa ttcttcctat gttcatggtg gagtagatgc      480

tagtggaaag ccccaggaag ctgtttat                                         508


<210> 3820
<211> 829
<212> DNA
<213> Homo sapiens

<400> 3820
gtcgctggag gagaggtccg ggctctccag gaaggtggct gcggcgacaa aatgaagata       60

ttcgtgggca acgtcgacgg ggcggatacg actccggagg agctggcagc cctctttgcg      120

ccctacggca cggtcatgag ctgcgccgtc atgaaacagt tcgccttcgt gcacatgcgc      180

gagaacgcgg gcgcgctgcg cgccatcgaa gccctgcacg gccacgagct gcggccgggg      240

cgcgcgctcg tggtggagat gtcgcgccca aggcctctta atacttggaa gattttcgtg      300

ggcaatgtgt cggctgcatg cacgagccag gaactgcgca gcctcttcga gcgccgcgga      360

cgcgtcatcg agtgtgacgt ggtgaaaggt gggatgtgtg tgggctgaaa ttccgagctg      420

cggttgtgca tgagaataca cccttcgtgg taccccatct ccgggacgtt ctcggctctg      480

tgcgttcagt ccctcaggaa ccgtggacct taatttacct tgctaagttc agaccttctc      540

ttcctttcct ttcctttcct ctcctgccca ttttcctgtt cttctgtcct tcaatacttc      600

tgtagcttcc cattcatgtt ctcttctccc agcaggcctc attgtgtgca gaaactgtgg      660

tgggggctgt gctgtctcct ccctgcctcc tgcctcctgc ggctgttgga tttgggaatg      720

accttggtga gagtctcact gctccagggt ctctttttgg tccaaaggct agacctatag      780

agttggatca ctttttttct ttccggtgaa ataaatggtt tttcaactt                  829


<210> 3821
<211> 599
<212> DNA
<213> Homo sapiens

<400> 3821
gacctttggc ctgactcaca ggacactaag gctccttttc tgaagaagcc ttttaccagt       60

ctcatttagg ggatgggaac aacatgtctt cacctaggga ctttagagca gagcctgtaa      120

acgattatga gggaaatgac tctgaagcag aagacttgaa tttcagggag actttgcctt      180

catcaagtca ggaaaacaca cctagatcaa aggtttttga aaataaagtt aattcagaga      240

aggtaaaact ttctcttcgg aatttcccac ataatgatta tgaggatgtt tttgaagagc      300

cttcagaaag tggcagtgat cccagcatgt ggacagccag aggccccttc agaagagaca      360

ggtggagcag tgaggatgag gaggctgcag ggccatcaca ggctctctcc cctctacttt      420

ctgttcaaca tcatggatat agtggcccaa atgagagaac aacgttctgg catggttcaa      480

acgaaggagc agtatcactt ttgttacgat attgtgcttg aagttcttcg gaaacttctg      540

actttggatt aagaaagact tctgttgcct ctcacttgaa attaccaagt gggtttgca       599


<210> 3822
<211> 693
<212> DNA
<213> Homo sapiens

<400> 3822
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg aatttcccac      120

ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat cccagcatgt      180

ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag gaggctgcag      240

ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt tctgaaggag      300

aactagatca gttggctcag attcggccat taatattcaa ttttcatgag cagacagcca      360

tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc atgcaggaat      420

ttatggcttt agaacttaag aatctgcctg gtgagttcaa ctctgggaat caaccaagca      480

acagagaaaa aaatagatac cgagatattc ttccatttca acatcatgga tatagtggcc      540

caaatgagag aacaacgttc tggcatggtt caaacgaagg agcagtatca cttttgttac      600

gatattgtgc ttgaagttct tcggaaactt ctgactttgg attaagaaag acttctgttg      660

cctctcactt gaaattacca agtgggtttg cac                                   693


<210> 3823
<211> 678
<212> DNA
<213> Homo sapiens

<400> 3823
ggcatcgtct gtaaagaatg agcccttatt agacactgaa tctgccagca ccttgatctt       60

ggacttccta gcttctagaa ctgagctgta tttgatgaaa gtactagaaa aatactggtt      120

gtacaagatc gaaataaatt gaaaaatatg tggaagtttc caggaggcct gtcagagcct      180

gaagaagata ttggagacac agcggttcga gaagtttttg aagagactgg tataaaatca      240

gaattcaggt ccgtcctgag tattcggcaa cagcacacaa atcctggagc ttttgggaag      300

tcagatatgt atatcatctg ccgcctaaag ccatattcat tcaccataaa tttttgccag      360

gaagaatgct taagatgtga gtggatggat ctcaatgacc tggcgaagac tgaaaataca      420

actcccatca ccagcagagt tgctaggctg ctgctgtatg ggtacagaga agggtttgac      480

aaaattgacc tgactgtgga agaacttcca gcagtttaca caggactgtt ttataaactc      540

tatcataagg aactgccaga gaattataaa actatgaaag gaattgatta aattcacatt      600

tatatgttta gaaacatgta gactaacgaa tgacataaga aatagtggac attttggatt      660

gattaaacat ctgactgt                                                    678


<210> 3824
<211> 487
<212> DNA
<213> Homo sapiens

<400> 3824
gcggccggcg cggggtcgac ggggacccag cgtcggcgga cccctagccg cggagaaggc       60

ggtggtctcg acattccccc atccccgccc tggagcaaag tctgaaatgg atgttacatg      120

agtcatttta agggatgcac acaactatga acatttctga agattttttc tcagtaaagt      180

agataaagat ggatgaatca gccttgttgg atcttttgga gtgtccggtg tgtctagagc      240

gccttgatgc ttctgcgaag gtcttgcctt gccagcatac gttttgcaag cgatgtttgc      300

tggggatcgt aggttctcga aatgaactca gatgtcccga gtgcaggact cttgttggct      360

cgggtgtcga ggagcttccc agtaacatct tgctggtcag acttctggat ggcatcaaac      420

agaggccttg gaaacctggt cctggtgggg gaagtgggac caactgcaca aatgcattaa      480

ggtctca                                                                487


<210> 3825
<211> 4207
<212> DNA
<213> Homo sapiens

<400> 3825
gcggcggcga aggcagcggc aggtcgggag caagatggcg ctgcggccag gagctggttc       60

tggtggcggc ggggccgcgg gagctggcgc ggggtccgcc gggggaggcg gcttcatgtt      120

tcctgttgca ggtgggataa gaccccctca agcaggcctg atgccgatgc agcaacaagg      180

atttcctatg gtctctgtca tgcagcctaa tatgcaaggc attatgggaa tgaattacag      240

ctctcagatg tcccaaggac ctattgctat gcaggcagga ataccaatgg gaccaatgcc      300

agcagcggga atgccttacc taggacaagc acccttcctg ggcatgcgtc ctccaggccc      360

acagtacact ccagacatgc agaagcagtt tgccgaagag cagcagaaac gatttgaaca      420

gcagcaaaaa ctcttagaag aagaaagaaa aagacgccag tttgaagagc agaagcaaaa      480

gctcagactt ttgagcagtg tgaaacccaa gacaggagag aagagtagag atgatgcttt      540

ggaagccata aaaggaaatt tagatgggtt ttccagagat gcaaaaatgc accctactcc      600

agcatcgcac cccaagaaac caggtgtggg agtatttccc tcacaggatc ctgctcagcc      660

cagaatgcct ccttggattt acaatgagag tttggttcca gatgcctata agaaaatctt      720

agaaaccaca atgactccaa ctggaataga tactgccaaa ctgtatccca ttctgatgtc      780

atctgggctt cccagggaaa ctcttggaca gatatgggcc ttagctaatc gaactacacc      840

tggcaaactt acaaaagaag aactttatac cgttctagcc atgatagcgg taacacagag      900

gggcgttcct gcaatgagtc ctgatgcttt aaaccagttc ccagcagctc ctattccaac      960

tttaagtggc ttttctatga ctctgcctac accggtgagt cagccaactg tgataccttc     1020

aggtcctgcg ggctccatgc ccctcagcct tggacagcca gtcatgggca ttaaccttgt     1080

tggaccagtg ggtggagctg cagcccaggc ttctagtggt ttcataccaa cctaccctgc     1140

aaatcaggta gtaaagccag aagaagatga cttccaggat tttcaagatg cttctaagtc     1200

aggatccctt gatgactcat tcagtgattt ccaagagttg cctgcttctt caaaaacaag     1260

taactcccag catggaaaca gtgccccttc tttgttgatg ccacttcctg gaactaaagc     1320

attgccttca atggacaaat atgctgtgtt taaaggaatt gcagctgaca agtcctctga     1380

aaatactgtt ccacctggag atcctggtga taaatatagt gctttcagag aacttgaaca     1440

gacagcagag aataaacctt taggagaaag ctttgcagaa ttcagatctg caggaactga     1500

tgatggtttc accgatttta aaacagccga tagtgtatca ccactagagc caccaacaaa     1560

agacaaaact tttccaccat ccttcccctc aggaactata caacagaaac aacaaacaca     1620

agtgaaaaac cctctgaact tagcagacct agatatgttt tcctcagtta attgcagcag     1680

cgagaaacca ttgtcttttt cagctgtgtt tagcacatca aaatcagttt ctacaccaca     1740

gtcaacaggt tctgctgcta ctatgacagc attggcagca acaaaaactt ctagtttggc     1800

tgatgatttt ggagaattca gcctttttgg ggaatattct ggtctagcac ctgttgggga     1860

gcaggatgac tttgcagatt ttatggcttt cagtaatagc tctatttcat ctgagcaaaa     1920

gccggatgac aaatatgatg cccttaaaga ggaagccagt cctgttcctc taaccagcaa     1980

cgtgggcagc acagtgaagg gtggacaaaa ctcgactgct gcgtctacca agtacgatgt     2040

cttcagacaa ctttctctgg aagggtctgg actaggtgtt gaagacctga aagataacac     2100

tccttcagga aaaagtgatg atgattttgc tgacttccac tccagtaaat tttcttccat     2160

aaactcggac aaatccctgg gagagaaagc agtggctttc agacacacca aagaagactc     2220

tgcatcagtg aagtccttag atctcccttc cattggtggc agcagtgttg gcaaggagga     2280

ctctgaagat gcactctctg ttcagtttga catgaaattg gctgatgtgg gaggagatct     2340

taagcatgtc atgtctgata gctctttgga tttaccaaca gttagtggcc agcatcctcc     2400

tgctgcagat atagaggact taaaatatgc tgcttttgga agctacagta gcaattttgc     2460

agtgagcaca cttacaagct atgactggtc agacagggat gatgcaactc agggcagaaa     2520

actctctcca tttgtcctct cagcaggaag tggatccccc tcagccacct caattcttca     2580

aaagaaagag acttcatttg gcagttctga aaacatcacc atgacatctc tctccaaagt     2640

aacgaccttt gtaagtgaag atgctcttcc agagaccacc ttcccagctc ttgccagttt     2700

taaagacacg attcctcaga ccagtgagca aaaggaatat gaaaacagag actataaaga     2760

tttcacaaaa caggacctgc ctacggctga acggagccag gaggccacgt gtcccagccc     2820

agcgtccagt ggtgcctctc aagaaacccc gaacgaatgt tcggatgact ttggagagtt     2880

tcaaagtgaa aagcccaaaa tcagcaaatt tgacttctta gtagccactt cacaaagcaa     2940

aatgaaatcc agtgaagaaa tgatcaaaag tgagctggca acctttgacc tttctgttca     3000

aggatcacac aagaggagtt tgagccttgg tgataaagaa ataagccgtt cttctccttc     3060

tccagctttg gagcagcctt tcagagaccg ttccaatact ctgaatgaga agcccgccct     3120

gcccgtcatc cgagacaagt acaaagacct gacgggagag gtggaggaaa atgagagata     3180

tgcatatgaa tggcagagat gcctggggag tgccctgaat gtcattaaga aggcaaatga     3240

taccttaaat ggaatcagta gtagttctgt ttgcacagaa gtaattcagt cagctcaagg     3300

catggaatat ttattaggtg ttgttgaagt gtacagggta accaagcgtg tggagctggg     3360

gataaaagcc actgcagtgt gcagtgagaa actccagcag ttgctgaagg acatcgataa     3420

agtatggaat aacctaatcg gcttcatgtc actcgccaca ctcacaccag atgaaaactc     3480

gctggatttt tcctcctgta tgttacggcc tgggattaaa aatgctcagg agcttgcctg     3540

tggagtgtgc ctcttgaatg tggactcgag gagccgggca ttcaactcag aaacagacag     3600

tttcaagctg gcctatggag ggcaccagta tcacgccagc tgtgccaact tctggatcaa     3660

ctgtgtcgaa ccaaagcctc ctggcctcgt cctgcctgac ctgctctgaa caactcctct     3720

gtgaagcatt gacttttttt tttctgtgac accccacggg gtgacaggga ccaataaata     3780

gaatgcgagc actgcacagt tcgcttccct gaatcgatat gaagaacacc gcaagggacg     3840

gggcccccgt catccccacg gccagtctgc aggacttcag gtaaaattgt cccacccaaa     3900

ctgcacgtgg caccagaagc ttgctcactt atctctactt aagattttct gaaatacgga     3960

ccacggcttt cttgatctaa ggaagaactt gctgctgcag tattgaaact gtgaagaact     4020

gacatttgaa gaaaaataga ttaccgttgc gggactagaa tgggcgactg cttggagcca     4080

gtgcttgttt ttatctagga cacttactgt cctgtgaagt agaatacatt tatctgcatt     4140

tagtttgtta atgtctgaaa tgaataaaaa gaggaaattg cgattaaact gatgttctgc     4200

tttttat                                                               4207


<210> 3826
<211> 560
<212> DNA
<213> Homo sapiens

<400> 3826
ttttcttcct cttccgggga cgttgtctgc aggcactcag aatggtccag cgtttgacat       60

accgacgtag gctttcctac aatacagcct ctaacaaaac taggctgtcc cgaacccctg      120

gtaatagaat tgtttacctt tataccaaga aggttgggaa agcaccaaaa tctgcatgtg      180

gtgtgtgccc aggcagactt cgaggggttc gtgctgtaag acctaaagtt cttatgagat      240

tgtccaaaac aaagaaacat gtcagcaggg cctatggtgg ttccatgtgt gctaaatgtg      300

ttcgtgacag gatcaagcgt gctttcctta tcgaggagca gaaaatcgtt gtgaaagtgt      360

tgaaggcaca agcacagagt cagaaagcta aataaaaaaa tgaaactttt ttgagtaata      420

aaaatgaaaa gacgctgctg gagtacaatg gcaggatctc ggctcaccgc accctctgcc      480

ttccaggttc aagtgattct cctgcctcag cctcccaagt agctgggatt ataggcatgt      540

gccaccatgc ctggctaatt                                                  560


<210> 3827
<211> 854
<212> DNA
<213> Homo sapiens

<400> 3827
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtgaacaa aaattgtttg ctggccccca ggatactaac tagacctttg gcctgactca      120

caggacacta aggctccttt tctgaagaag ccttttacca gtctcattta ggggatggga      180

acaacatgtc ttcacctagg gactttagag cagagcctgt aaacgattat gagggaaatg      240

actctgaagc agaagacttg aatttcaggg agactttgcc ttcatcaagt caggaaaaca      300

cacctagatc aaaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc      360

ggaatttccc acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg      420

atcccagcat gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg      480

aggaggctgc agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg      540

tttctgaagg agaactagat cagttggctc agattcggcc attaatattc aattttcatg      600

agcagacagc catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata      660

tcatgcagga atttatgttc aacatcatgg atatagtggc ccaaatgaga gaacaacgtt      720

ctggcatggt tcaaacgaag gagcagtatc acttttgtta cgatattgtg cttgaagttc      780

ttcggaaact tctgactttg gattaagaaa gacttctgtt gcctctcact tgaaattacc      840

aagtgggttt gcac                                                        854


<210> 3828
<211> 724
<212> DNA
<213> Homo sapiens

<400> 3828
taatctcagt atttgtcagg attttgcttt tcctgacttg ctttgcacag aatgttccct       60

ggatgaaagc ccagaaatca ccaacatttc agacaatgct ttctgagcct tactctgttc      120

cacatttcat aacaggaccc ctaccatgga ggagaccatc aaagatcccc ccacatcagc      180

tgtcttgctg gatcactgtc atttctctca ggtcatcttt aacagtgtgg agaagttcta      240

catccctgga ggggacgtca catgtcatta taccttcacc cagcatttca tccctcgtcg      300

aaaggattgg attggcatct ttagagtggg gtggaagaca acccgtgagt attacacctt      360

catgtgggtt actttgccca ttgacctaaa caacaaatca gctaaacagc aggaagtcca      420

attcaaagct tactacctgc ccaaggatga tgagtattac cagttctgct atgtggatga      480

ggatggtgtg gtccggggag caagtattcc tttccaattc cgtccagaaa atgaggaaga      540

catcctggtt gttaccactc agggagaggt ggaagagatt gagcagcaca acaaggagct      600

ttgcaaagaa aaccaggagc tgaaggacag ctgtatcagc ctccagaagc agaactcaga      660

catgcaggct gagctccaaa agaagcagga ggagctagaa accctacaga gcatcaataa      720

gaag                                                                   724


<210> 3829
<211> 401
<212> DNA
<213> Homo sapiens

<400> 3829
ctgtcaggtt gccgtctagg tagcggttgt gcttgctgag gctgcacttg ctgacactgc       60

agctgcgacg cggctaagag gcgcagagcg aggagtcggg atttggtcgc gagcggcgac      120

ggaaataact ctgaagtaag agaaactgca atagaagttg gaaaaggatg tgatttccat      180

atttcaagtc attcaaagac agatgagtca tcaccagtgt tatcgccaag gaagccttct      240

cacccagtca tggatttttt cagttcacat cttttagctg actcttcctc accagcaaca      300

aattctagtc atacagatgc ccatgaaata cttgtgagcg attttcttgt ttctgatgaa      360

aaccttcaga agatggaaaa tgtgcttgat ctttggagtt c                          401


<210> 3830
<211> 1626
<212> DNA
<213> Homo sapiens

<400> 3830
tggggccgtg tgcagacccg cgtgtggcgc aggcaaggac cctcaaaata aacagcctct       60

accttgcgag ccgtcttccc caggcctgcg tccgagtctc cgccgctgcg ggcccgctcc      120

gacgcggaag atctgactgc agccatgagc agcaatgagt gcttcaagtg tggacgatct      180

ggccactggg cccgggaatg tcctactggt ggaggccgtg gtcgtggaat gagaagccgt      240

ggcagaggtt tccagtttgt ttcctcgtct cttccagaca tttgttatcg ctgtggtgag      300

tctggtcatc ttgccaagga ttgtgatctt caggaggatg cctgctataa ctgcggtaga      360

ggtggccaca ttgccaagga ctgcaaggag cccaagagag agcgagagca atgctgctac      420

aactgtggca aaccaggcca tctggctcgt gactgcgacc atgcagatga gcagaaatgc      480

tattcttgtg gagaattcgg acacattcaa aaagactgca ccaaagtgaa gtgctatagg      540

tgtggtgaaa ctggtcatgt agccatcaac tgcagcaaga caagtgaagt caactgttac      600

cgctgtggcg agtcagggca ccttgcacgg gaatgcacaa ttgaggctac agcctaatta      660

ttttcctttg tcgcccctcc tttttctgat tgatggttgt attattttct ctgaatcctc      720

ttcactggcc aaaggttggc agatagaggc aactcccagg ccagtgagct ttacttgccg      780

tgtaaaagga ggaaaggggt ggaaaaaaac cgactttctg catttaacta caaaaaaagt      840

ttatgtttag tttggtagag gtgttatgta taatgctttg ttaaagaacc ccctttccgt      900

gccactggtg aatagggatt gatgaatggg aagagttgag tcagaccagt aagcccgtcc      960

tgggttcctt gaacatgttc ccatgtagga ggtaaaacca attctggaag tgtctatgaa     1020

cttccataaa taactttaat tttagtataa tgatggtctt ggattgtctg acctcagtag     1080

ctattaaata acatcaagta acatctgtat caggccctac atagaacata cagttgagtg     1140

ggagtaaaca aaaagataaa catgcgtgtt aatggctgtt cgagagaaat cggaataaaa     1200

gcctaaacag gaacaacttc atcacagtgt tgatgttgga cacatagatg gtgatggcaa     1260

aggtttagaa cacattattt tcaaagacta aatctaaaac ccagagtaaa catcaatgct     1320

cagagttagc ataatttgga gctattcagg aattgcagag aaatgcattt tcacagaaat     1380

caagatgtta tttttgtata ctatatcact tagacaactg tgtttcattt gctgtaatca     1440

gtttttaaaa gtcagatgga aagagcaact gaagtcctag aaaatagaaa tgtaatttta     1500

aactattcca ataaagctgg aggaggaagg ggagtttgac taaagttctt tttgtttgtt     1560

tcaaattttc attaatgtat atagtgcaaa ataccatatt aaagagggga atgtggagga     1620

ctgaaa                                                                1626


<210> 3831
<211> 760
<212> DNA
<213> Homo sapiens

<400> 3831
ttcatgtctt cttactcagt tgtcaatttc tcagtaacct tatatgacca ccttatttaa       60

aattatattg tccttgccct agcatttcct atgtttcttc cttgtctttt ctccatggca      120

cttataaatc atttgatata ctacagtata tatatgtttt attttttatt ttattgtctg      180

ttttccttac ttagaataag gttcacggta ggagggattt ttgtctattt tgttcattgc      240

tatattctta ccccctagat gagtatctgg caggtaataa gtgttcaacc aatactgctg      300

aatgaataaa tattttttgc tttagttttt cttataaggc taaaaattca caaagcatat      360

atcaatgaat caggaggatc tagatccgga tagtactaca gatgtgggag atgttacaaa      420

tactgaagaa gaacttatta gagaatgtga agaaatgtgg aaagatatgg aagaatgtca      480

gaataaatta tcacttattg gaactgaaac actcaccgat tcaaatgctc agctatcatt      540

gttaattatg caagtaaaat gtttaaccgc tgaactcagt caatggcaga aaaaaacacc      600

tgaaacaatt cccttgactg aagacgttct cataacatta ggaaaagaag agttccaaaa      660

gctgagacaa gatcttgaaa tggtactgtc cactaaggag tcaaagaatg aaaagttaaa      720

ggaagactta gaaagggaac aacggtggtt ggatgaacag                            760


<210> 3832
<211> 2034
<212> DNA
<213> Homo sapiens

<400> 3832
ttcctgagga ggactgccgg tcgttcggac gtcttgcctg tcgctggagg agaggtccgg       60

gctctccagg aaggtggctg cggcgacaaa atgaagatat tcgtgggcaa cgtcgacggg      120

gcggatacga ctccggagga gctggcagcc ctctttgcgc cctacggcac ggtcatgagc      180

tgcgccgtca tgaaacagtt cgccttcgtg cacatgcgcg agaacgcggg cgcgctgcgc      240

gccatcgaag ccctgcacgg ccacgagctg cggccggggc gcgcgctcgt ggtggagatg      300

tcgcgcccaa ggcctcttaa tacttggaag attttcgtgg gcaatgtgtc ggctgcatgc      360

acgagccagg aactgcgcag cctcttcgag cgccgcggac gcgtcatcga gtgtgacgtg      420

gtgaaaggct cttgtcagga tggtgaagct gttcatcgga aacctgcccc gggaggctac      480

agagcaggag attcgctcac tcttcgagca gtatgggaag gtgctggaat gtgacatcat      540

taagaattac ggctttgtgc acatagaaga caagacggca gctgaggatg ccatacgcaa      600

cctgcaccat tacaagcttc atggggtgaa catcaacgtg gaagccagca agaataagag      660

caaaacctca acaaagttgc atgtgggcaa catcagtccc acctgcacca ataaggagct      720

tcgagccaag tttgaggagt atggtccggt catcgaatgt gacatcgtga aagattatgc      780

cttcgtacac atggagcggg cagaggatgc agtggaggcc atcaggggcc ttgataacac      840

agagtttcaa ggcaaacgaa tgcacgtgca gttgtccacc agccggctta ggactgcgcc      900

cgggatggga gaccagagcg gctgctatcg gtgcgggaaa gaggggcact ggtccaaaga      960

gtgtccgata gatcgttcag gccgcgtggc agacttgacc gagcaatata atgagcaata     1020

cggagcagtg cgtacgcctt acaccatgag ctatggggat tcattgtatt acaacaacgc     1080

gtacggagcg ctcgatgcct actacaagcg ctgccgtgct gcccggtcct atgaggcagt     1140

ggcagctgca gctgcctccg tgtataatta cgcagagcag accctgtccc agctgccaca     1200

agtccagaat acagccatgg ccagtcacct cacctccacc tctctcgatc cctacgatag     1260

acacctgttg ccgacctcag gagctgctgc cacagctgct gctgcagcag cagccgctgc     1320

tgctgttact gcagcttcca cttcatatta cgggcgggat cggagccccc tgcgtcgcgc     1380

tacagcccca gtccccactg ttggagaggg ctacggttac gggcatgaga gtgagttgtc     1440

ccaagcttca gcagccgcgc ggaattctct gtacgacatg gcccggtatg agcgggagca     1500

gtatgccgat cgggcgcggt actcagcctt ttaaagcttg aggtgagagg ggtggggtgt     1560

tccctcttct ggttttgcca tccctcctgc agcctaaagg gctccaatta ggctgccctg     1620

cttgcttgct tgcttttgca gggttagggg aaggttacta ggatggctca caggctagag     1680

agaagtccta actgcttaac tttaaaatac atagagttcc ttggccctca tggctatttt     1740

tcagggcttc tggtagtggg agtcaatttg attctatttg tgcctagaaa aataaagaat     1800

gatgtgctgg tgaatcttgg gtcacctatg tactatacta taattgaacc ttacctgggg     1860

acccacacgt tcaggctcag gtgttttgtt tcttagagcc tttgttaagt ttcctacgtg     1920

tgcgacattc ctaaggtctt caagtttcct attctgtttt gtgctgtgtg aaagttctga     1980

tatgacccct gatgataaag tccataactg tagttaactg gtcatcactg ctca           2034


<210> 3833
<211> 732
<212> DNA
<213> Homo sapiens

<400> 3833
tggctgtagc gactggttgc gggaggctgg actctggtga ctgtgtatgg ttgcatatgc       60

tccgttttcc tctccctgtc gtgctgggcc tttgaaaccg gcttctttgc tggtggctgc      120

ttgctctgct tgtattactc ttcaaaatat ttattcactg gtactgaaga gagacataac      180

tttgttgtca gaaattccat tatcagaggt agaaatcatg taagagacac tgaaatgttt      240

tccaaaatgt cagaaaaagg aaaggtgaaa aattagacga tttcaagaat tggagctgaa      300

tctgatgtta agtaatggca acaggtgact taaaaagaag cttacggaac ctagaacagg      360

tgctccgctt gctaaattat cctgaagagg tggactgtgt aggtttgata aagggagacc      420

cagcagcatc tttgcccatc atcagctatt cttttacctc atactcacct tatgtaacag      480

aacttataat ggaatccaat gtagagctca tagcaaaaaa tgacttgcgc tttatagatg      540

ctgtctataa gcttcttcgt gatcaattta attataaacc aattttgaca aaaaagcagt      600

ttatccaatg tgggtttgca gaatggaaaa tccaaattgt ttgtgatatt ttgaattgtg      660

tgatgaaaaa gcacaaggaa ttaagcagtc ttcagaagat tccatcacaa caaagaaaga      720

aaatcagttc tg                                                          732


<210> 3834
<211> 891
<212> DNA
<213> Homo sapiens

<400> 3834
gattccacac tgaggcgagc gcggcggccg gggtggtagt ggcagtgttc gtgtgctcag       60

gtctgaatcg ccgagggagg aggcggtgga ggaagaggtg gcggcggtgg cggtggtcgt      120

agcggtggcg gaggaggcgg gtacgaatca gctgcgggcg gagacatggc caacatcgcg      180

gtgcagcgaa tcaagcggga gttcaaggag gtgctgaaga gcgaggaggt ccggtttatc      240

actaaaatat ggcatcctaa tattagttcc gtcacagggg ctatttgttt ggatatcctg      300

aaagatcaat gggcagctgc aatgactctc cgcacggtat tattgtcatt gcaagcacta      360

ttggcagctg cagagccaga tgatccacag gatgctgtag tagcaaatca gtacaaacaa      420

aatcccgaaa tgttcaaaca gacagctcga ctttgggcac atgtgtatgc tggagcacca      480

gtttctagtc cagaatacac caaaaaaata gaaaacctat gtgctatggg ctttgatagg      540

aatgcagtaa tagtggcctt gtcttcaaaa tcatgggatg tagagactgc aacagaattg      600

cttctgagta actgaggcat agagagctgc tgatatagtc aagcttgcct cttcttgagg      660

agcaccaaca tctgttattt ttaggattct gcatagattt cttttaaact ggcattcttg      720

cctaatgatg ttatctaggc accattggag actgaaaaaa aaaaatccct gctctgtaaa      780

taaagctaat taaacgtctg tgtaaattta aaaaggggaa atactttaat tttttttctt      840

aatagtgtaa aaattccctg agctaagcta aaaccatgga agaaacatgc t               891


<210> 3835
<211> 1071
<212> DNA
<213> Homo sapiens

<400> 3835
attccattcg cgctccgcgg cgcgaggcaa tcgtccggtg tgtgagcccg ggagccggag       60

gtgtagcggc agagacattg ttcttgccgg ctccctacgg tgccgtgtgt gcgtgagaga      120

agaccagtct ttcctctagg ttaggccggg cacggtggct cacgcctgta atcccagcac      180

tttgggaggc cgaggcgggc ggatcatctg aggtcaggag ttcgaggcca gcctgaccaa      240

catggagaaa ccccgtctct actaaaaata cataattagc caggtgtggt ggcgtatgcc      300

tgtaatccca gctactcggg aggctgaggc aggagaatcg cttgaacccg ggaggcggag      360

gttgcagtga gctgagattg cgccattgca ctccagcctg ggcaaggaga gtgaaactcc      420

gtctcaaaaa aaaaaaaaaa aaattatttc agcatttgac attgtgcagc aaagaaatgg      480

ttatggagaa gcccagtccg ctgcttgtag ggcgggagtt tgtgaggcaa tattatactt      540

tgctgaataa agctccggaa tatttacaca ggttttatgg caggaattct tcctatgttc      600

atggtggagt agatgctagt ggaaagcccc aggaagctgt ttatggccaa aatgatatac      660

accacaaagt attatctctg aacttcagtg aatgtcatac taaaattcgt catgtggatg      720

ctcatgcaac cttgagtgat ggagtagttg tccaggtcat gggtttgctg tctaacagtg      780

gacaaccaga aagaaagttt atgcaaacct ttgttctggc tcctgaagga tctgttccaa      840

ataaatttta tgttcacaat gatatgtttc gttatgaaga tgaagtgttt ggtgattctg      900

agcctgaact tgatgaagaa tcagaagatg aagtagaaga ggaacaagaa gaaagacaac      960

catctcctga acctgtgcaa gaaaatgcta acagtggtta ctatgaagct caccctgtga     1020

ctaatggcat agaggagcct ttggaagaat cctctcatga acctgaacct g              1071


<210> 3836
<211> 569
<212> DNA
<213> Homo sapiens

<400> 3836
ctcgaatgca gcgtctacgc ctggtgaatg gacgcactct taccaattct gctctgggag       60

atgcagcggt aacctaccga gcgcagaggc cggcgcgcac ccgtggagcc cgcgctcgcg      120

atccctcctc gtgccagggc cccagggcag tcaaggcctg ccgaccgtta ggcgggtcaa      180

ggggtacaca gggtgcgaat tcgttaggca aaagctgggt acaggcgcga gccacaggca      240

cggaaacctc gcgccgaccg gggccctagg cccgacgacg gcagctgacc agcttcggcc      300

ggtttgggga taaagggaag acaggcggcg cggggagtgg gaacgcctga aggccgcgcc      360

cctcctttca ggtcggccag gagcgcgccg tttgtttcga cgccggaccg cgtaagagac      420

gatgatgttg ggcacggaag gtggagaggg attcgtggtg aaggtccggg gcttgccctg      480

gtcttgctcg gccgatgaag tgcagaggtt tttttctgac tgcaaaattc aaaatggggc      540

tcaaggtatt cgtttcatct acaccagag                                        569


<210> 3837
<211> 1475
<212> DNA
<213> Homo sapiens

<400> 3837
ggggtctcgg cgatcgctgc tcctcctcct ccttctcctc ctcttttttc tcctccgcct       60

cctccccccg ccgcctcgcc accgccgcgg ctagggctgg aggcgccgct gtcattcctg      120

tgccggagga accggcgctg ccggtgcctg ggggtcgggg cgcgggcgaa gccgggccgc      180

ggaggacaca acaggccaaa atcctgagca tgatggaaga caataagcag ctcgcgctcc      240

gcatcgatgg ggcggtccag tcggccagcc aggaggtgac caacctgcga gccgaactca      300

cggccaccaa ccggagactg gcggaactga gcggcggcgg cggccccggc ccgggcccgg      360

gagccgcggc cagcgcctcg gcggcggggg actcggcggc gacgaacatg gagaaccccc      420

agcttggagc gcaagtgctc ctgcgggaag aagtgtcgcg gctccaggag gaagttcacc      480

ttctccggca gatgaaggag atgttggcga aggacctgga ggagtcgcag ggcggcaagt      540

cctctgaggt cctctcggcc accgagctca gggtccagct ggcccagaag gagcaggagc      600

tagccagagc caaagaagcc ttgcaggcca tgaaagctga tcggaagcgc ttaaagggcg      660

agaagacaga cctggtgagc cagatgcagc agctgtatgc cacactggag agccgcgagg      720

agcagctccg agacttcatc cgcaactatg agcagcaccg caaggagagc gaggatgcgg      780

tcaaagcgct ggccaaggag aaggacctgc tggagcgtga gaagtgggag ctgcggcgcc      840

aagccaagga ggccacagac cacgccacgg cactgcgctc ccagctggac ctcaaggaca      900

accggatgaa ggagctggag gccgagctgg ccatggccaa acagtcctta gctacgctga      960

ccaaggacgt ccccaagcgg cattccctcg ccatgccggg cgagacggtg ctcaatggca     1020

accaggagtg ggtggtgcag gcggacctcc cgctgaccgc agccatccgg cagagtcaac     1080

agactctcta ccactcacac ccccctcacc ctgcggaccg gcaagcggtc agggtgagcc     1140

cctgccactc ccggcagccc tctgtcatct ccgacgcatc tgccgccgaa ggcgaccggt     1200

cgtccacacc gagcgacatc aactcccctc gacaccggac acactccctc tgcaacggcg     1260

acagtcccgg cccagttcag aagaacctgc acaaccctat tgtacagtca ctagaggatc     1320

ttgaagacca aaaacggaaa aagaagaaag agaagatggg attcggctcc atctcccgcg     1380

tcttcgccag agggaagcag cggaagtccc tcgaccccgg cctctttgat ggtaccgccc     1440

ctgattatta catagaggag gacgcggact ggtga                                1475


<210> 3838
<211> 4534
<212> DNA
<213> Homo sapiens

<400> 3838
gacgttaggc tccgactctt aacggagacg catttttatt tctgttgttt acgattcgct       60

atagattcct tgtttctcac ttcgtagcac gagccactct gaccatcaag atcagaaaaa      120

cttctcagct gcaagttaga agtggactgg ccattgagga ggctctcagc ggagtcgctc      180

ttcacaggag tcttgaacgc ggtgtggaat cggcagcgag gaatcctgga gcacagagaa      240

gctcccagct ttgaaggtct tgcggtgaag catcaagtgt acctgatttg tgaacctatc      300

ttgcttcagt tggtttcctc ctaaatatta ggcagatggg attggctggt ctgtgctctg      360

ctaggtgaaa aattagacga tttcaagaat tggagctgaa tctgatgtta agtaatggca      420

acaggtgact taaaaagaag cttacggaac ctagaacagg tgctccgctt gctaaattat      480

cctgaagagg tggactgtgt aggtttgata aagggagacc cagcagcatc tttgcccatc      540

atcagctatt cttttacctc atactcacct tatgtaacag aacttataat ggaatccaat      600

gtagagctca tagcaaaaaa tgacttgcgc tttatagatg ctgtctataa gcttcttcgt      660

gatcaattta attataaacc aattttgaca aaaaagcagt ttatccaatg tgggtttgca      720

gaatggaaaa tccaaattgt ttgtgatatt ttgaattgtg tgatgaaaaa gcacaaggaa      780

ttaagcagtc ttcagaagat tccatcacaa caaagaaaga aaatcagttc tggtaagtca      840

gaacctcctt tgggcaatga gaaaatatct gcagaggctg ttggcgttga tatcagtggc      900

aggtttatga cctcaggaaa gaagaaagct gtggtgattc gtcacttgta taatgaagat      960

aatgttgaca tttctgagga tacattaagt ccaataacag atgttaatga agcagttgat     1020

gtgtctgact taaatgctac tgaaataaag atgcctgaag taaaggttcc tgaaatcaag     1080

gctgagcaac aggatgtaaa tgttaatcct gagattactg cactacaaac tatgcttgct     1140

gaatgccaag aaaatcttaa gaaactgact tcgatagaga aaaggttaga ctgtttggaa     1200

caaaaaatga aaggaaaagt gatggtagat gaaaacacct ggactaatct tcttagtcgt     1260

gtcactcttc ttgaaacaga aatgcttttg tctaaaaaga atgatgaatt tatagagttt     1320

aatgaagtta gtgaagacta cgcttcttgt agtgacatgg accttctgaa tcctcacaga     1380

aaaagcgaag tagagaggcc agcaagtatt cctctgtcct ctggctatag tacagcatca     1440

tcagattcaa ctcccagagc ctctactgtt aattactgtg gtttgaatga gatttcagag     1500

gaaacaacaa tccagaaaat ggaaaggatg aaaaaaatgt ttgaagaaac tgcagagtta     1560

ctgaaatgtc caaatcacta cttgtaggat tttctacatg aacttttttc taggactttg     1620

gttactatac atattgtata ttttaagaat tctttataca attttaatat actgcaatac     1680

tgcagttttt gacaatttgg attccatttg gtatatgaat ttttgcattc attattgaat     1740

aactctttta atatttttga gcaatgatta tactgcttta ccttgtgtca cttttttttt     1800

ttttaggaaa aactcatgtt ccagtatatt tctcttacag agtgaagtca ttacagcact     1860

gtatttctgt gttgacattt gttggcagtg tgctaagtaa tgttttttaa agcacaggct     1920

tgaggactat ggtttacatc ctgttggaaa cattccaaat gggacttgtg tattataccc     1980

aggaggctct catatatacc atcttggcat ctgtactgat gaataagtta taatgaacag     2040

ttaaaaatgc tcattgaaaa ttaaataaaa caaaaaggca gttatttcat gcttggtcaa     2100

aaacatcaat acctttccaa ttaacactga gaaattaagg ttaagattct ccttttgtac     2160

tgggaaacag gctggaggac tatggtcctc aagtttagac caagaggact atggtctcaa     2220

ggttcaccat gagaaatgtg ttgaacattt tagtatgctc tattgtataa tttttttgga     2280

gggggggatg gagtttcgct gttgttgccc aggctggagt gcaatagcac gatcttggct     2340

caccgcaacc tctgcctacc gggttcaagt gattcttgtg cctcagcctc ctgagtagct     2400

gggattatag gcatgcacca ccatgcccag ctaattttgt atttttatta gagacagggt     2460

ttctccgtgt tggtcaggct ggtctcaaac tcctgacctc aggtgatctg cctgtcttgg     2520

cctccggcgt aacacttttt aagaccagtg taacagaaag agaatgtagc cattctagcc     2580

accgttaaaa gatacacagt gaggtgttgt gttttgtttt tttaatgatg aaaagttaca     2640

cattttttgg agagaaaagt cttagctgaa ggtaaatcaa tggaaaaatg aaatttattt     2700

ttaatattac tactatatga attatctttt tttaaacttg tagataaaag tgttccagta     2760

atcagaaaat cctcaagaaa attgacttca ttatttggaa ggaaaattag tatttttttt     2820

aatattatat ggaccatctg attatatttt atttattcat ctatttatgg tatgtatgta     2880

taattctata ttacactgtc aaatataaaa tattgttata tgagtagaaa tcacttaaat     2940

tttttttgtg tttgtgaatt tgaaacagtg taagaaatca cttttaagaa aacattttta     3000

gaattccttt gttttttttt tttttctttt tgaaacaggg tctcactcta ttgcccaggc     3060

tggagtgcac tggcgtgatc tcggctcact gcaccttctg cctaccgagt tcaagcgatt     3120

cttgtgcttc agcctcctga gtagctggga ctataggcct gtaccgtcat gcctggctaa     3180

tttttgtatt tttgtagaga cagggtttca ccatgttgcc cagtctgttc tcaaactcgt     3240

gagctaaagc tactcgccca cctggatgtc ccaaagtgct agattccatg ggtgagtcac     3300

catgcttggc cacattttta gtattctaat aaacagttgg tcatcagaac tttaaaatgg     3360

tagcctacag aaacatacaa ttttgaattt aacagagttt cagtaaatat ttccagaatt     3420

aatgaagcat gttagcttta attttttcaa ttgtgagaga agtacattta taaaaattaa     3480

gaggttaaga ggttatagtt ataagggaaa aaacttctgt atcgattaac tcctaaaata     3540

tcagtaccag catggaatta tagcaccacc ttgtggttaa catgccagta ttttaccttt     3600

tgttaaaaca agtgatttcc catcaaacag gataatattt tttccctttt gaaaaattca     3660

attttaaaaa gaaacatttt tgaagttttc ttatggaaga tagaaaaaaa gttaagtctc     3720

tttctaccct ttcttttttt ctttatatag tgcagatata cacacagaga agggacttaa     3780

aacatttcta atctcctagt ttatatacag tgtgcaaaat ataagtaagt atatattgaa     3840

aatataaaat atttcatata tgttatcagg tggaaattta gaatccaaat tttcttaaac     3900

tttaataact tgtctaacaa ctctctaata gggactaaaa atcaactcaa tatatcatac     3960

atttacactt acaaagagtc tttatctaga caacataatt tttggaaaaa taaagcaaat     4020

tcaactttat tggagttatt ggacagatca gcaaattgtt attttaaaaa gttttcttgt     4080

ttaggcaatt tggtaagtgg tttctagtta taaactagcc actgttgatt aacttgagaa     4140

ggtgaagcag gggagttctg aagagattac ctagagctac ataaccctaa gttaagtaaa     4200

attttcactt tcattctttt cattctctca taaactggtt gaaaaaacac tgtactacca     4260

acaaaggtgt cagttgcttg tgctgccctg tctatgttat gctctgaata ggtctcggta     4320

aagattatat ggaaatacta taaagaatac ataaggtaaa atactagtca gaaagggttc     4380

agaagaagtt agcatcaact gtatgaaaat tctaggtaaa gctaagtact attgagttgg     4440

aaaaaagtaa ttctatcatg tttgcttgtt ttcctctact gtttttaatg tgatgttgta     4500

atatatttta aaaataaaac ttgaaaacgt tggg                                 4534


<210> 3839
<211> 584
<212> DNA
<213> Homo sapiens

<400> 3839
gcgcgtgtgt ccgcgcgtgt ccgcgtgtgg gtccgtgtgc gcgtcccggt cccgcggcgg       60

cgacggcggc ggcggcggcg gcggctgcag gacgagccga gaggctcagc catatttgat      120

ggttttgttg ctttgctcgg gagttctcgg gagtaattta atgccgaagg ctgcctgctg      180

tttcccgggg agatcatgaa acgaggtcgc cttcccagca gcagtgagga ttctgacgac      240

aatggcagcc tgtcaactac ttggtcccag aattcccgat cccagcatag gagaagctcc      300

tgctccagac atgaagatcg aaagccttca gaggtgttta ggacagacct gatcactgcc      360

atgaagttgc atgactccta ccagctgaat ccggatgagt actatgtgtt ggcagatccc      420

tggagacagg aatgggagaa aggggtccag gtgcctgtga gcccggggac catccctcag      480

cctgtggcca gggttgtgtc tgaagagaaa tccctcatgt tcatcaggcc caagaagtac      540

atcgtgtcat caggctctga gcctcccgag ttgggctatg tgga                       584


<210> 3840
<211> 896
<212> DNA
<213> Homo sapiens

<400> 3840
aattcctccc tgcagtttga aactgtcagg ttgccgtcta ggtagcggtt gtgcttgctg       60

aggctgcact tgctgacact gcagctgcga cgcggctaag aggcgcagag cgaggagtcg      120

ggatttggtc gcgagcggcg acggaagaat atgaagaact gcttcattat gctatagtga      180

ctccaaatat tgaaccctgt gcttcacagt catctcatcc taagggagaa ttggtgccag      240

atgtcagaat ttctacaatt catgatattc ttcatagtca aggaaataac tctgaagtaa      300

gagaaactgc aatagaagtt ggaaaaggat gtgatttcca tatttcaagt cattcaaaga      360

cagatgagtc atcaccagtg ttatcgccaa ggaagccttc tcacccagtc atggattttt      420

tcagttcaca tcttttagct gactcttcct caccagcaac aaattctagt catacagatg      480

cccatgaaat acttgtgagc gattttcttg tttctgatga aaaccttcag aagatggaaa      540

atgtgcttga tctttggagt tcaggtctta agacaaacat catatctgaa ctaagtaaat      600

ggagacttaa ttttattgac tggcaccgaa tggaaatgag aaaagagaaa gaaaaacatg      660

cagcacattt aaaacaactg tgtaatcaga tcaatgaatt gaaggagctg caaaaaacct      720

ttgaaatctc cattgggaga aaagatgagg tgatttctag cttgtctcat gccataggca      780

agcaaaagga aaagatagag ttgatgagaa cattcttcca ctggcgaatc ggccatgtca      840

gagccagaca ggatgtttat gaaggtaaac tagctgacca gtactaccag agaact          896


<210> 3841
<211> 545
<212> DNA
<213> Homo sapiens

<400> 3841
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgtt caacatcatg gatatagtgg cccaaatgag agaacaacgt tctggcatgg      420

ttcaaacgaa ggagcagtat cacttttgtt acgatattgt gcttgaagtt cttcggaaac      480

ttctgacttt ggattaagaa agacttctgt tgcctctcac ttgaaattac caagtgggtt      540

tgcac                                                                  545


<210> 3842
<211> 570
<212> DNA
<213> Homo sapiens

<400> 3842
gtttgttgtg gtgacgagct gtgagcaatg gcctgtgttt atgctgggcg agctttcttt       60

cctacttggg gaggggggtt caggatggga ggatgcgggt agggaagagg gggggaaaac      120

ccccaagctc cacaacattt taagtttttt gaagtcattc caaataaatc taagtgaact      180

attgattttg atacaaagca acagcctctg ccacactgaa gaagtgagct ttaagcagag      240

actagaaggg tatggcatca cagctgcaag tgttttcgcc cccatcagtg tcgtcgagtg      300

ccttctgcag tgcgaagaaa ctgaaaatag agccctctgg ctgggatgtt tcaggacaga      360

gtagcaacga caaatattat acccacagca aaaccctccc agccacacaa gggcaagcca      420

actcctctca ccaggtagca aatttcaaca tccctgctta cgaccagggc ctcctcctcc      480

cagctcctgc agtggagcat attgttgtaa cagccgctga tagctcgggc agtgctgcta      540

catcaacctt ccaaagcagc cagaccctga                                       570


<210> 3843
<211> 567
<212> DNA
<213> Homo sapiens

<400> 3843
agcccagcgc ctcggccgaa cccctccgca gcagttcata gccctgatga agcaagttac       60

tctgctctcc taataaatgc aagaaaatga ccttggaggg cctttttaat tacacataga      120

agtgacaatt tgctgcctgc tgtttcccgg ggagatcatg aaacgaggtc gccttcccag      180

cagcagtgag gattctgacg acaatggcag cctgtcaact acttggtccc agaattcccg      240

atcccagcat aggagaagct cctgctccag acatgaagat cgaaagcctt cagaggtgtt      300

taggacagac ctgatcactg ccatgaagtt gcatgactcc taccagctga atccggatga      360

gtactatgtg ttggcagatc cctggagaca ggaatgggag aaaggggtcc aggtgcctgt      420

gagcccgggg accatccctc agcctgtggc cagggttgtg tctgaagaga aatccctcat      480

gttcatcagg cccaagaagt acatcgtgtc atcaggctct gagcctcccg agttgggcta      540

tgtggacatc cggacgctgg ctgacag                                          567


<210> 3844
<211> 578
<212> DNA
<213> Homo sapiens

<400> 3844
gaagcagttg agtgctgcag cggcagtcgt cgcccctgcc gccgctgcca ccgaaggaag       60

catcccagac accgggaaga gacagggttt caccatgctg tccaggctgg tctcgaactc      120

ctgatctcaa gtgttccgct cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc      180

caccggatgg aagatggtac cccaaagcat atcatccaga tgacaggatt taagatggaa      240

gaaaaagaag cgctagtcaa attactttta aaactagatt gcacttttat taagagtgag      300

aaatacaaaa attgtacaca tcttatagct gaacgcctat gtaagagtga aaaattttta      360

gcagcttgtg cggcaggaaa gtggatacta accaaggact atataattca tagtgccaaa      420

agtggcagat ggcttgatga aacaacttat gaatggggat ataaaattga aaaagattcc      480

cgttattcac ctcaaatgca atctgcacct aaaagatggc gtgaagaact gaaacgcact      540

ggtgctccag gagccttcca cagatggaaa gttgtcct                              578


<210> 3845
<211> 8843
<212> DNA
<213> Homo sapiens

<400> 3845
gtgtgtgttt cccctgccgc ggggaaatgg ctgctgttgc ttctgggcca gaggaagaga       60

atgaggtaga gtgttctttt gcctccgagt aggaccgaga gtgttgggaa gaggagcgcg      120

tccccgggga aatgagacta atagggatgc caaaggaaaa atatgatcct ccagatcctc      180

gcagaattta taccatcatg tcagcagagg aggtagccaa tgggaaaaaa tctcactggg      240

cagaattaga aatctcgggt agagtgcgga gcctaagtac atcactttgg tcattgacac      300

acttgacagc gctgcaccta aatgacaatt accttagtcg cattccacct gatattgcca      360

agcttcataa tctggtttac ctggatctgt catccaataa actcagaagt ttaccagcag      420

aactaggaaa catggtgtct ctcagggaat tgcttttaaa taacaatctg ttacgggttt      480

tgccttatga acttggtcgg ctcttccagc tacaaactct aggtttgaaa ggcaatcctt      540

tatcacagga tattctcaac ttataccagg acccagatgg aacccgaaag ctactgaact      600

tcatgcttga caatctcgca gttcatccag agcagcttcc tccgaggcca tggattacat      660

taaaagaacg agaccaaatt ctgccgtcag catcattcac ggttatgtgt tacaatgtgt      720

tatgtgataa atacgctacc cggcagctat atggctattg cccatcctgg gcattaaact      780

gggaatacag gaaaaaggga attatggaag aaattgttaa ctgtgacgca gatatcatta      840

gtcttcagga agtggaaaca gagcaatact tcactctctt tctgccagca ttgaaggagc      900

gtggatatga tggatttttt tctccaaagt cacgtgccaa aatcatgtct gagcaggaga      960

gaaagcatgt agatggttgt gcaatattct tcaaaacaga aaaatttaca ttggtgcaga     1020

agcatacagt ggaatttaac caagtggcga tggctaattc agatggatcc gaagctatgc     1080

tgaacagagt gatgacaaaa gataacattg gtgtcgctgt ggtattagag gtccacaaag     1140

aactatttgg agcaggtatg aagcctattc atgctgcaga caaacagctg cttatagtgg     1200

caaatgccca catgcattgg gacccagagt attctgatgt gaagctcatc cagaccatga     1260

tgtttgtctc agaggttaaa aacattctgg agaaagcctc tagtaggcct ggaagcccaa     1320

ctgcagatcc taattccatc ccgctggtgc tatgtgcaga tcttaactca ttgccagatt     1380

caggtgttgt ggaatactta agcaatggag gagtagctga caaccataaa gacttcaagg     1440

aactaaggta caatgagtgt cttatgaact tcagctgcaa tggaaagaat ggaagctcag     1500

aagggagaat cacacatggc ttccaactta agagcgccta tgaaaataac ttgatgcctt     1560

acaccaatta cacctttgat ttcaaaggcg tgattgacta cattttctat tccaagactc     1620

atatgaacgt gcttggtgtc ctggggcctt tagatcctca atggctggtt gagaacaaca     1680

tcactgggtg tccacaccct cacatccctt cagaccactt ctcactgtta acacaacttg     1740

aactccaccc tccactcctg cctcttgtca atggtgttca cttgcctaat cggaggtagt     1800

ggagtactgc cccgccaaga cggggatctg ttgctatgga cctgtacagt tgtaaatcaa     1860

agtatgtagg agtgaagtat ggccatcctt aagctgcttc ttcaggtttc tttcattatg     1920

tgtttgctgt aagactttgt acatttttgt gcatattggt atcatttggc agtagggctg     1980

gaaccaaagt attactctct ttacaaaatt ttaatttaac atgtttttaa attggacctt     2040

ctttatattg tattaacagc cagcattcaa aattgataaa ttaccaattt gaggcccaat     2100

aacagtgtat ttgtttttcc aaaacaaata ctttcttttg aatggtttca gtgagccaac     2160

cattttataa aaggcaattt ttaaaaacta taaatacagt attttaaact gaatgatgat     2220

atgccttcca gggaaaacct tgaatttttc ctttataact gacttttgga ttccaaagtc     2280

atttgcacat taacagagta cttaaattta cttgttcagt ccataaacta tgatatagcc     2340

tctatacatg gtaagaaaat ttgaaaaatt aaagatggtt gcacagtata cttttataat     2400

ccagcatgta acaccacatg acaatttgtt ggccaaatgc tggtttggag tttttttgag     2460

gaatcacttt ggtttttttg tcctttatat ataaccttat tggaagtatt aattctaagc     2520

ctgtctctca agtttattta tagagaaaaa gtaagtaatc tgtattgcca cataccttga     2580

aaatagaatg tggtatgttt aggatgccca cggaatgaat ttttccttat tccaattcaa     2640

ccttctgtct ggttgtgcca ggaaaacaga tgttatatga cctatgtcat ttttgccatt     2700

atagtcaaat gttaaaagaa gaaaaaagtc tgctgaataa aaaggccttg atcaaagttt     2760

cagatgggga aaatcataca gatattttat gtgtttccaa catagattat gtggctgttg     2820

gtttcttgag atgacagtgc aaaggatttg ggagagagaa caaatttggg gcagtagttg     2880

aaaacgttgg gtcattttcc tgactctagc tgccaaatgg ccatcatatg cttttaatct     2940

ttgtttcagt tgtctgtcag ggttgaatta agaagctact ggtttattcc caattgttga     3000

tgcctttagg tatgttggaa tctttttttt gcctaggagg ggccagttga aaatctgtga     3060

ctcaagaggc agtgaacaga atactgtttt ctggggaaaa attggttggc tacttgatgt     3120

taattatggc acagtaacag gaaaaggttg tgtctgtgtt tttaagtttt tctttattct     3180

gcttttttgc tgctataaga gttttctgaa atttatattt taaacttttc atgcacttta     3240

ctgtttctag tctcaaaatg tgatattttt aataaacaag aaattttcca ttatgtgaat     3300

gaaattttaa aagacaatag cctatatttg tgtctcacta atatataaag tataggtcaa     3360

atttaaatta tttaattagt tttaaatata cacaatttgt ctcctctttc aaacctgaca     3420

tcttcggctg ttttattagt cttaaatgat gcatttactt tggtcatttt atgctaattt     3480

cttccatagt aaattaatca ggctatataa ggtaatattt ccccagaggg taattttagt     3540

gggacgaggg tggtgggatg atgtcatatc atacatggga ttgcatcaga agggttctgt     3600

aaagcctgaa ctccctttta aaagtgccta gtgatagagg cgttgtttgt catctattat     3660

aattggaatg tcattgtagt tcagtgaatt ttgatgtaaa taaaatatct tttaaaaatg     3720

ttaaagtacc aggataaaca aacaaaaaga aacaaccctt aagatgacag attttcctca     3780

acatgcaggt ttcccttctt atatacctca agtatccaac atctagccat gcaaattgat     3840

tacctgaagc atagtactgg aaagtagaat agcatgaaaa acttaatttt gtggacatta     3900

cctttttttg taatcagcta ctgtatgttt tattttagat cttttgtttt gggtgggttt     3960

tctgctctgg aggtatatgc actaacaaaa cattttcctc ctttcatata cgcatgttaa     4020

ttagcaatgt gagcaatatt tcctaccata cttcactccc aatatttttt gagatgtttg     4080

tataaaatgg aatttaaagt tcacttatga ttgtatatga accacagagg agcccattta     4140

ttaataaaaa acttttttaa tagttaaatg tagagggaaa aaataaaaaa aaatgggaaa     4200

cattgtaaac agcttaagtt tattttgtgt atgatcgagg cactctgttg caggaaggtg     4260

tgtaattggg ttctctctgc ttcaaatgcg ctctttcaaa ccattcatta tcctgtgtat     4320

ttttaatgtg gttttagtaa atgttggtag tagctctgtt gaagtaggta attgtgttat     4380

gttttgggtg gtacacactt ggggcatggt aacccaaatt tcatgtgcac ggtttccctt     4440

tagcccactg cccaaatttc acataccctt caccctttgt tccctttgta aaaggagtgg     4500

tatctgtttt gagctgccaa ttcagatgat cagaaatgct gctttcctca gcattgtctt     4560

gttaaaccgc atgccatttg gaactttggc agtgagaagc caaaaggaag aggtgaatga     4620

catatatata tatatattca atgaaagtaa aatatatatg ctcatatact ttctagttat     4680

cagaatgagt taagctttat gccattgggc tgctgcatat tttaatcaga agataaaaga     4740

aaatctgggc atttttagaa tgtgatacat gtttttttaa aactgttaaa tattatttcg     4800

atatttgtct aagaaccgga atgttcttaa aatttactaa aacagtattg tttgaggaag     4860

agaaaactgt actgtttgcc attattacag tcatacaagt gcatgtcaag tcacccactc     4920

tctcaggcat cagtatccac ctcatagctt tacacatttt gatggggaat attgcagcat     4980

cctcaggcct gacatctggg aaaggctcag atccacctac tgctccttgc tcgttgattt     5040

tgttttaaaa tattgtgcct ggtgtcaact tttaagcaac agcactgcct aaaagcaagc     5100

agagaacaga atcccagcac cattctatag gcaacttttt agaattcaga tatagtaaat     5160

ctgttccaga tttatgatgt tttatgtaaa aaaaattttg tataataaca tagctgaata     5220

tttttgtttc atttctttga tgtaaggcgt gtgaacattc gtttgaatat cacatgttga     5280

agtcaggtat ggcacaatgg gttctgagac cagcttttcc tcccctccca tttgccttgt     5340

tccaagctct ttcttttcaa attacttttc tgatattcat aggcaggtat ttaattttac     5400

taattagcat cctgtgtgaa tgtattaaag aagccactgt gttttagtgt agttggcaaa     5460

aatataaaag ctgtttctta tttgccccta tttttttggt gtcttaaagt tatatattaa     5520

atcacagaga agcaagggag aaagttgaaa gatatctaag gctcatatca cttgattcta     5580

tggtagatta tattagaatt gaggatgtgg cacattaaaa ctggaacatg ggcaaatata     5640

gtgttccatt ttaaaattct aagtttatat tgttaaatgg gtgaaaattt aagtttatat     5700

ttgcatttcc aagcgtttct aaaaatcact aatgccatct atacttttag tatgaaacag     5760

cagactatag aaagcacagg gaagaatagg ctaaatacat tctttgaaga accagaggca     5820

tataaccaca tcattatgtc attcctaata catggctaga ttttctaatg ataaaattga     5880

ctgtgtccca atgcttattt gattctaagc ttttttattc tgtttctgag atattttaat     5940

agctttgcaa aatatgctga ccagtttttg gaaaataatg gtttttatag caagcaaaga     6000

ctttatggca cattttcaaa atagcactca tacatactta cattttgaca gaaatgtgaa     6060

ttctcacatt gatgagatat tctttttccc acctgcccta ccctttaaaa aaggtcactt     6120

ttctaatgtg tagtagattc atttacgcct ttccctttga gtcataccat gtttggagaa     6180

ctgtgtgaat tgtaggtaga gaaattaact agggaagcca gaagcttgaa ctaaagtttt     6240

aaatttgtag gcagatgaga acttttatac tatggttgct ttgggcgatt ctaattttgt     6300

aatagcatca tgatcaccaa aattaattca aacattttag tacatcttta atctgtctta     6360

tttaccaaag ttctaatctg tttaagaaca ggatgccaag agcatctttc attttataga     6420

atgatatgct cacctttata agtgtcacct aaaagcttga gggtaaaaaa gaagcagccc     6480

atatatctaa actacaggat gtcttgaaca agattcacag aaagaaagaa aaaaaagcag     6540

ttctttccag gaaggtggta aggaagagca tgcatatttc ttgttttaac caaatacctt     6600

ttttatgtaa atgtctctat taaaccccag gtcctacacc aggaaatagg gtgataacca     6660

ggaaaatacc aagctttaac ccagttggca gttccttgtg gcatacattt ggttagactt     6720

gggtttttcc tggaaccaaa ggaaaataag catgttgagt tcttcgttca acagacatga     6780

cattgaagta atagaatatt ttttaagtaa aatagttttc actttcaaag cctatgacat     6840

aaggacattt gtgcttatta attgttaatt tttttttatg gtacattgta taaactgagt     6900

agcattgaac tgcattttag aagtatgtca tcagaaacaa atcacattat ggaaaggata     6960

tacaaatgcc aagtgatatg actcttttgg catggtggta gcatggtcca ttcagctttc     7020

agaatctttc ggaggctcta gtttggtgcc tagtactagt tatttttgtt agaacaatct     7080

ctcaaaattt agataatttt ccagttgtat gtctgtcact tttaactcta aagcgtaaga     7140

atcatggtaa ccctctcaga agtggtcctt tcttgctcat ttcagtttcg tattaacttc     7200

aaatcactga tgtattgtct ttcaagctat caattgttat atgtaccaat ttaatttagt     7260

ttgtagttat ctgaagtcac aaaattggtt cagcattgat gtcaaacaat ggctttgctt     7320

cttaccaaac agacttagta tcctgctgct tgtttcaatc ttgatgcagt aagtgatgca     7380

gtatctgggt ctgtatttac ttagaaactg tactgtcctt tctctgtgct taacttgcta     7440

aaaatatatt cccttacctg tgaaattcct gagcggtgct ctgccaactt ttcaagggga     7500

gggatttgga tggctgtgtt actgcacact ggatctggaa ttgttcaggg ttatgagtga     7560

caaatttctt aaacaccagc agcactgaga tgtgcactat gggcattcgt acagttgttg     7620

tccaaatgca aacaactttt tcatcttgga gaagctgaga tacagagttc aatagaacta     7680

cttggaatat tttgagaagg ttgaatgttt catctttggc tttgttgtct ctggagtggg     7740

gaagtatgga gggctttttt tttttttttt tttttttttt tttttttttt taaagagagt     7800

gtgtatgtac tttttctctc tataagggcc agggtgttgg tcaaattcac catcgattaa     7860

tttatatctt ctgttgtgat ttttttcaac tatataacaa gtgccaacta attgtccatg     7920

ggacaatcta cttttccact caatttatcg ttttgagtag ggaaaggttc atttattttc     7980

attacctggc attaagttaa agaattcatt attttgcata catttgagtc attctgtgac     8040

ctataaagtg tttttgtaac tatctaattc taatggttgc aaagcaaagc acatgactgt     8100

aaaaccaagc aaggtgtttt agtaactttt tccctgaata cttggtagtt tccattgata     8160

ctattccaaa acaaattctg ctgttttagg ttgtatattt actttgcttt tgttctaaga     8220

aaaagccaag gactaaatca acttgttttt gtgtttcagt aatcagttta aaatctaaga     8280

ttttttttta aattagacta tttaatgaag tgccatgtaa ttgtagcttg ctagtgttta     8340

atgtttaata gactggttct gtaggtgttt taaccattta acactctctg ccatccctgg     8400

agaaagtggt tctactctta ctgaacacat tctctctgac aaaatcacca gctgctttat     8460

ttttctattt attacagtta aacagttgat gaggtctgaa tcttgaccaa aactgctcag     8520

ctgagatgtt tttcacaata gacactgtac aaagtgtgcg tgcaaaagga cacggttggt     8580

agtatttttt cattaatgtg aacattgact aaaaaaaagc agtcctgcct tttaaatctt     8640

gtggcagctc agaagggagg tgcttaagaa ccttaactac tatgtcagat aacaaaatat     8700

ttttttccat tttggagatt ggttactgct cacacatgat gtatagggct aaatatatgc     8760

ttgtttcctt gcacctgtgt acttcccctc tctccctccc tttccttccc ctgtaggcaa     8820

taaatggcca ttttgcaact gca                                             8843


<210> 3846
<211> 2774
<212> DNA
<213> Homo sapiens

<400> 3846
caatctgagg agcaggagga ccggggcgcc ggtgtcctgc cgcctccttc tccttgctct       60

cacctgcgcc tattagtcca cgcgccttca aggccagggg ctacagccca gacagagagg      120

ggacagcaga gggagagaga gcacctgagg atacagagct ggcactggac tgccttttca      180

ccccccaggt gatgagtgag gttcgaagaa cggaagattt aaaaagcagc cggggcctcc      240

gtattgaatg aaagacccag tgcaaagaca tcaccatgaa cactagcatt ccttatcagc      300

agaatcctta caatccacgg ggcagctcca atgtcatcca gtgctaccgc tgtggagaca      360

cctgcaaagg ggaagtggtc cgcgtgcaca acaaccactt ccacatcaga tgcttcacct      420

gtcaagtatg tggctgtggc ctggcccagt caggcttctt cttcaagaac caggagtaca      480

tctgcaccca ggactaccag caactctatg gcacccgctg tgacagctgc cgggacttca      540

tcacaggcga agtcatctcg gccctgggcc gcacttacca ccccaagtgc ttcgtgtgca      600

gcttgtgcag gaagcctttc cccattggag acaaggtgac cttcagcggt aaagaatgtg      660

tgtgccaaac gtgctcccag tccatggcca gcagtaagcc catcaagatt cgtggaccaa      720

gccactgtgc cgggtgcaag gaggagatca agcacggcca gtcactcctg gctctggaca      780

agcagtggca cgtcagctgc ttcaagtgcc agacctgcag cgtcatcctc accggggagt      840

atatcagcaa ggatggtgtt ccatactgtg agtccgacta ccatgcccag tttggcatta      900

aatgtgagac ttgtgaccga tacatcagtg gcagagtctt ggaggcagga gggaagcact      960

accacccaac ctgtgccagg tgtgtacgct gccaccagat gttcaccgaa ggagaggaaa     1020

tgtacctcac aggttccgag gtttggcacc ccatctgcaa acaggcagcc cgggcagaga     1080

agaagttaaa gcatagacgg acatctgaaa cctccatctc accccctgga tccagcattg     1140

ggtcacccaa ccgagtcatc tgcgacatct acgagaacct ggacctccgg cagagacggg     1200

cctccagccc ggggtacata gactccccca cctacagccg gcagggcatg tcccccacct     1260

tctcccgctc acctcaccac tactaccgct ctggtgattt gtctacagca accaagagca     1320

aaacaagtga agacatcagc cagacctcca agtacagtcc catctactcg ccagacccct     1380

actatgcttc ggagtctgag tactggacct accatgggtc ccccaaagtg ccccgagcca     1440

gaaggttctc gtctggagga gaggaggatg attttgaccg cagcatgcac aagctccaaa     1500

gtggaattgg ccggctgatt ctgaaggaag aaatgaaggc ccggtcgagc tcctatgcag     1560

atccctggac ccctccccgg agctccacca gcagccggga agccctgcac acagctggct     1620

atgagatgtc cctcaatggc tcccctcggt cgcactacct ggctgacagt gatcctctca     1680

tctccaaatc tgcctccctg cctgcctacc gaagaaatgg gctgcacagg acacccagcg     1740

cagacctctt ccactacgac agcatgaacg cagtcaactg gggcatgcga gagtacaaga     1800

tctaccctta tgaactgctg ctggtgacta caagaggaag aaaccgactg cccaaggatg     1860

tagacaggac ccgtttagag ggaaactttt ggaagagtgg ctgcttatga gattccaaaa     1920

tgaagtgttg gccaacaccg ctcatggcca tcctggattt tcccagtggc ttcccttcct     1980

gctcgcctcc ctgaacaggg gagaaagctt aacctctctt ctcctctcca aacctttcac     2040

cttgaatggg taatgtttgg tgggggctgt tccttcttgg agaagccttg agtcggacca     2100

ttttgagatc atggaggaag gatgaagaag tgaaaatgac aataatgact ctcaagaggc     2160

tggcgatgtg acatggcaaa tgtagaactg acttaaattg aacaaaccct cactgagcac     2220

ctctgatgtt gagcacctgc tgaatactga gcactgaatg ggggaggggg aggggagcac     2280

ggggtgagtc aacctgggac tcggtctcag ggatatgcct accaatagcg ggtatcgtaa     2340

ggcatgtacc caaacataac ggatgtaagg cagaaagtga tcggagaagg aatgagaaag     2400

tgtgcgtgat gttaatgaaa agtcatatgc agctagagca gacccaggaa agctttctgg     2460

aagagattgc atctgaggaa attcaggaag gatctttgta gattgggggg agattctaaa     2520

ttgaaggggt gatggggtga ggggccagag ggaagtctgc tgtgttctca tgtaggatgt     2580

cagccctccc tgcaacttct ctttttggcc aatgtctttt cactttcctg accctttaga     2640

atcatcccca gccagacgca atcatggaag ttgccttatt gtcactggtt aagaacttgg     2700

cgagattgaa gggcttttgt tattgttgtt ggatattttt gtttcccata aaagcacatc     2760

atttcaaccc taaa                                                       2774


<210> 3847
<211> 578
<212> DNA
<213> Homo sapiens

<400> 3847
gttgctcaaa ccgagttctg gagaacgcca tcagctcgct gcttaaactg gaaacaaaag       60

tctcaacttc caacctcttt gcagctagga gtggccaagt agcatagatc tggtgaatga      120

actgcaggtg ggaatttctg agaaggtttc cttcttaaat agaaagatta aaccacaggt      180

tccattatgg gtcgacttga tgggaaagtc atcatcctga cggccgctgc tcaggggatt      240

ggccaagcag ctgccttagc ttttgcaaga gaaggtgcca aagtcatagc cacagacatt      300

aatgagtcca aacttcagga actggaaaag tacccgggta ttcaaactcg tgtccttgat      360

gtcacaaaga agaaacaaat tgatcagttt gccaatgaag ttgagagact tgatgttctc      420

tttaatgttg ctggttttgt ccatcatgga actgtcctgg attgtgagga gaaagactgg      480

gacttctcga tgaatctcaa tgtgcgcagc atgtacctga tgatcaaggc attccttcct      540

aaaatgcttg ctcagaaatc tggcaatatt atcaacat                              578


<210> 3848
<211> 1405
<212> DNA
<213> Homo sapiens

<400> 3848
ggaggtaccg gctcaggctt gggatcccgg ctgcgggttt ggcggcgctg cgccggcagg       60

cagcgaggcc gggcgggccc tgggccctcg cgcccctccc gcgaggcctg tcatgcaggg      120

ccccgccggg aacgcgagcc ggggactgcc aggcgggccg ccctccacag tcgcgtccgg      180

ggcgggccgc tgcgagagcg gcgcgctcat gcacagcttc ggcatcttcc tgcaggggct      240

gctcggcgtc gtggccttca gcacgttaat gctcaaacgc ttcagagaac caaagcatga      300

aagacgtccg tggaggatat ggtttttaga cacttccaaa caagccatag gaatgctgtt      360

catccacttt gcaaatgtat acctagcaga tctcactgaa gaggaccctt gttcactgta      420

cctcatcaac ttcctcctgg acgccactgt gggcatgctg ctcatctacg tgggggtgcg      480

cgccgtcagc gtcctggtag agtggcagca gtgggagtcc ctgcgcttcg gcgaatatgg      540

agaccctctg cagtgtggag cctgggtcgg gcagtgcgct ctttacatcg tgatcatgat      600

ttttgaaaag tctgtcgtct tcatcgtcct cctaatactt cagtggaaaa aggtggccct      660

gttgaatccc attgaaaacc cagacttgaa gctggccatc gtcatgctga tcgtcccctt      720

ctttgtcaac gctttgatgt tttgggtagt ggacaatttc ctcatgagaa aggggaagac      780

gaaagctaag ctagaagaaa ggggagccaa ccaggactcg aggaatggga gcaaggtccg      840

ctaccggagg gccgcatccc acgaggagtc tgagtctgag atcctgatct cagcggatga      900

tgagatggag gagtccgacg tggaggagga cctccgcaga ctgacccccc tcaagcctgt      960

gaagaaaaag aagcaccgct ttgggctacc cgctggtgct caggaagccc ctatcaagaa     1020

gaagcgcccc cctgtgaagg acgaggacct gaagggggcc cgaggaaacc tgaccaagaa     1080

ccaggaaatc aagtccaaga cctaccaggt catgcgagag tgtgagcaag ctggctcggc     1140

cgccccgtcg gtgttcagcc gcacccgcac aggtaccgag actgtctttg agaagcccaa     1200

agccggaccc accaagagtg tcttcggctg agaagtgtgc gccactcccc ttgctgcccg     1260

aatgctcgga aacaggagcc tttcccagga actctttttt atgccagaac gcttcctctc     1320

ccctgctgtc tctggggctg ccaccctccc ccacagtcca ggcccttcag ccaagggctc     1380

tgcaccagca ccttggaagc accaa                                           1405


<210> 3849
<211> 594
<212> DNA
<213> Homo sapiens

<400> 3849
catttcgtct tagccacgca gaagtcgcgt gtctagttct ggtcctcccc gctttgcagt       60

ttgtttcgac gccggaccgc gtaagagacg atgatgttgg gcacggaagg tggagaggga      120

ttcgtggtga aggtccgggg cttgccctgg tcttgctcgg ccgatgaagt gcagaggttt      180

ttttctgact gcaaaattca aaatggggct caaggtattc gtttcatcta caccagagaa      240

ggcagaccaa gtggcgaggc ttttgttgaa cttgaatcag aagatgaagt caaattggcc      300

ctgaaaaaag acagagaaac tatgggacac agatatgttg aagtattcaa gtcaaacaac      360

gttgaaatgg attgggtgtt gaagcatact ggtccaaata gtcctgacac ggccaatgat      420

ggctttgtac ggcttagagg acttcccttt ggatgtagca aggaagaaat tgttcagttc      480

ttctcagggt tggaaatcgt gccaaatggg ataacattgc cggtggactt ccaggggagg      540

agtacggggg aggccttcgt gcagtttgct tcacaggaaa tagctgaaaa ggct            594


<210> 3850
<211> 594
<212> DNA
<213> Homo sapiens

<400> 3850
gcagttcttg agttccacat gcagagcaga tgcgacagct agaagtgagt agggcccaga       60

ccctggccca ggaagatcca ctaaaggagg ccatccttcc gccttcttct gcaggagtca      120

gggggcgtgt aaaggtgatt tgttcgccaa gaaaagcact tttagtaaag cacagatgtt      180

aatctagatc atggaaaagt gccacacact agatttagca cataagcaag gagtctctag      240

aacactcaga agaaaatgaa tgaatccatg aatgaatgga caagtgagag cccagagcag      300

ctgaagccat gaagtgcttt ggaaagagaa gcgtgcctgg gaaaagagag tggctgagtg      360

ctaagagcag ggtgaacacc atggaaaact tgaaattgaa aacatcacaa ttttaatgag      420

aaaaagcgca acccaaagtg aagagcacca ttataacaaa ggcgatgcaa accagtaatg      480

cagaatccta ttgctctata aaaatttgaa ttgcttgaat ctattacaaa tttttgccag      540

tgtgcttcct gcctcaagga tggatggaaa ggcagatgta aagtccctca tggc            594


<210> 3851
<211> 1258
<212> DNA
<213> Homo sapiens

<400> 3851
agccgtggtc gcgctgtgtg tgtgtgtgag tggagagtga gtgcgggacc tgaggctgtg       60

tgtgtgtgaa ctgtggccac tggcggggtc gggggggggc agcggcggag ccgcctcgga      120

cggcaaagcc atgactacag tagtggtaca tgtggactcc aaagctgagc tcactaccct      180

gctggagcag tgggaaaagg aacatggcag tgggcaggac atggtaccta tccttaccag      240

gatgtctcaa ttgattgaaa aagaaactga agagtatcgt aaaggggatc cagacccatt      300

tgatgatcga catcctggtc gagctgatcc agagtgtatg ctgggccact tgctgagaat      360

actcttcaag aatgatgatt tcatgaatgc actggtgaat gcatatgtga tgacaagccg      420

agagccccct ttaaacactg cagcttgcag actcctatta gacatcatgc cagggctgga      480

aactgctgtc gtctttcaag aaaaggaggg aattgtcgag aatcttttca aatgggcccg      540

agaggccgat caaccattga ggacatattc tactggactg ttaggaggtg ctatggaaaa      600

tcaagacatt gctgccaact atagagatga aaattcacag ctggtggcaa tagtgcttcg      660

aagactgagg gagctacagc tacaggaagt ggctttgcgg caggaaaaca agcgtcccag      720

tccacggaag ctctcttctg aacccctttt gcctctggat gaggaggctg tggatatgga      780

ctatggtgac atggctgtag atgtagtgga tggagaccaa gaggaagctt ctggagacat      840

ggagatctcc tttcatcttg attcaggcca caagactagt agcagagtga actcaacaac      900

caaacctgag gatggaggat taaagaaaaa caagtcagca aaacagggtg acagagagaa      960

ctttaggaaa gccaagcaaa agttgggttt ctcatcttct gatccagatc gcatgtttgt     1020

tgagctgtct aatagcagtt ggtcagaaat gtctccctgg gtgattggca ccaattatac     1080

cctttatcct atgactcctg ctatcgagca gcgactcatt ctccaatatt tgacccctct     1140

aggagaatat caggagctac ttcccatatt catgcaactt ggatcacggg agctgatgat     1200

gttctatatt gacctgaagc aaactaatga tgtcctgctt acatttgagg cactaaag       1258


<210> 3852
<211> 1549
<212> DNA
<213> Homo sapiens

<400> 3852
gtgcgcagcg gcgtatgtgg ggccgtgtgc agacccgcgt gtggcgcagg caaggaccct       60

caaaataaac agcctctacc ttgcgagccg tcttccccag gcctgcgtcc gagtctccgc      120

cgctgcgggc ccgctccgac gcggaagatc tgactgcagc catgagcagc aatgagtgct      180

tcaagtgtgg acgatctggc cactgggccc gggaatgtcc tactggtgga ggccgtggtc      240

gtggaatgag aagccgtggc agaggtggtt ttacctcgga tagagacatt tgttatcgct      300

gtggtgagtc tggtcatctt gccaaggatt gtgatcttca ggaggatgcc tgctataact      360

gcggtagagg tggccacatt gccaaggact gcaaggagcc caagagagag cgagagcaat      420

gctgctacaa ctgtggcaaa ccaggccatc tggctcgtga ctgcgaccat gcagatgagc      480

agaaatgcta ttcttgtgga gaattcggac acattcaaaa agactgcacc aaagtgaagt      540

gctataggtg tggtgaaact ggtcatgtag ccatcaactg cagcaagaca agtgaagtca      600

actgttaccg ctgtggcgag tcagggcacc ttgcacggga atgcacaatt gaggctacag      660

cctaattatt ttcctttgtc gcccctcctt tttctgattg atggttgtat tattttctct      720

gaatcctctt cactggccaa aggttggcag atagaggcaa ctcccaggcc agtgagcttt      780

acttgccgtg taaaaggagg aaaggggtgg aaaaaaaccg actttctgca tttaactaca      840

aaaaaagttt atgtttagtt tggtagaggt gttatgtata atgctttgtt aaagaacccc      900

ctttccgtgc cactggtgaa tagggattga tgaatgggaa gagttgagtc agaccagtaa      960

gcccgtcctg ggttccttga acatgttccc atgtaggagg taaaaccaat tctggaagtg     1020

tctatgaact tccataaata actttaattt tagtataatg atggtcttgg attgtctgac     1080

ctcagtagct attaaataac atcaagtaac atctgtatca ggccctacat agaacataca     1140

gttgagtggg agtaaacaaa aagataaaca tgcgtgttaa tggctgttcg agagaaatcg     1200

gaataaaagc ctaaacagga acaacttcat cacagtgttg atgttggaca catagatggt     1260

gatggcaaag gtttagaaca cattattttc aaagactaaa tctaaaaccc agagtaaaca     1320

tcaatgctca gagttagcat aatttggagc tattcaggaa ttgcagagaa atgcattttc     1380

acagaaatca agatgttatt tttgtatact atatcactta gacaactgtg tttcatttgc     1440

tgtaatcagt ttttaaaagt cagatggaaa gagcaactga agtcctagaa aatagaaatg     1500

taattttaaa ctattccaat aaagctggag gaggaagggg agtttgact                 1549


<210> 3853
<211> 1785
<212> DNA
<213> Homo sapiens

<400> 3853
tcggtgggtt cccgtgcggc ggcggccaag gaggaggaga cacagttgga gcagctccgt       60

gggctgactg gggcgaggcc tcagcagcgc gagcttgagt gcggccgagc ctgcggcgcc      120

ttcccctgcg ggtggggacg agcgggcccc gcggcgtcat cggcggcgag gtgagcggcg      180

gccggcgggc gggagctctg gcgggagccg cgccggcctg acgcgctgtc gccgctggtt      240

gcaggagccg ccgcgcctcg gcctagcatg tcggaagcgg gcgaggagca gcccatggag      300

acgacgggcg ccaccgagaa cggacatgag gccgtccccg aaggcgagtc gccggccggg      360

gctggcacgg gcgccgcggc gggggctgga ggcgcgaccg cggcgccccc gagcgggaat      420

cagaacggcg ccgagggcga ccagatcaac gccagcaaga acgaggagga cgcgggaaaa      480

atgttcgttg gtggcctgag ctgggatact agcaaaaaag atttaaaaga ctattttact      540

aaatttggag aggtcgttga ctgtacaata aaaatggatc ccaacactgg acggtcaaga      600

gggtttgggt ttatcctgtt caaagatgca gccagtgtgg agaaggtcct agaccagaag      660

gagcacaggc tggatggccg tgtcattgac cctaaaaagg ccatggctat gaagaaggac      720

ccggtgaaga aaatcttcgt tgggggtctg aatcctgaag ccactgagga aaagatcagg      780

gagtactttg gcgagtttgg ggagattgag gccattgaat tgccaatgga tccaaagttg      840

aacaaaagac gaggttttgt gtttatcacc tttaaagaag aagaacccgt gaagaaggtt      900

ctggagaaaa agttccatac tgtcagtgga agcaagtgtg agatcaaggt ggcccagccc      960

aaagaagtct atcagcagca gcagtatggc tctgggggcc gtggaaaccg caaccgaggg     1020

aaccgaggca gcggaggtgg tggtggaggt ggaggtcaga gtcagagttg gaatcagggc     1080

tacggcaact actggaacca gggctacggc taccagcagg gctacgggcc tggctatggc     1140

ggctacgact actcgcccta tggctattac ggctacggcc ccggctacga ctacagtcag     1200

ggtagtacaa actacggcaa gagccagcga cgtggtggcc atcagaataa ctacaagcca     1260

tactgaggcg gcagcaggag cgaccaactg atcgcacaca tgctttgttt ggatatggag     1320

tgaacacaat tatgtaccaa atttaacttg gcaaactttc tattgcctgt cccatgtgca     1380

tcttatttaa aatttccccc atggaaatca ctctcctgtt gactatttcc agagctctag     1440

gtgtttaggc agcgtgtggt gtctgagagg ccatagcgcc atcatgggct gatttttatt     1500

accaggtccc ccagaagcag gtgggaggct ctgcttcctg ctgccgctct gcagcctgga     1560

cctgtggacc ctggttgtaa agagtaaatt gtatcttagg aaaccagtgt cacctttttt     1620

tcacctttta attttatatt atttgcgtca tacatttcct gtaacggaag tgttaatttt     1680

actgtacttt ttggtacctt ttgggaatct aatgtattgt aaggtatttt acacgtgtcc     1740

tgattttgcc acaacctgga tattgaagct atccaagctt ttgaa                     1785


<210> 3854
<211> 2486
<212> DNA
<213> Homo sapiens

<400> 3854
gttgctggct ttttcaggag ctgctcgctc gcagccagag acgctgcttt ttttttccgg       60

gttcggagcc gttccggatg ctttaggctg ccggatgtct gatctccgaa taactgaggc      120

gtttctgtac atggattatc tgtgttttag agcactttgc tgcaagggac caccacctgc      180

acgaccagaa tatgacctgg tttgcatagg cctcacaggt tctggcaaaa ccagtctgtt      240

gtccaaactc tgcagtgaaa gccccgataa cgtcgtgtcg accacaggtt ttagtattaa      300

agcagtgcca ttccagaatg ccatcttgaa tgtaaaagaa cttggagggg ctgataacat      360

ccggaaatac tggagccgct actaccaagg atctcaaggg gtaatatttg tattagacag      420

tgcctcttca gaggatgatt tagaagctgc tagaaatgag ctgcactcag ctcttcagca      480

tccacagtta tgcactttac cctttttaat attggccaat catcaagaca agccagcagc      540

tcgctcagta caagagatca aaaaatattt tgaacttgaa ccacttgcac gtggaaaacg      600

ctggattcta cagccctgct cactggatga catggatgca ctgaaagaca gcttctctca      660

gctgattaat ttgttagaag aaaaagacca tgaagctgta agaatgtgaa atctggcaaa      720

gaaaacaggc tcccaaaagg ccttgaacct atcatgttag tttctcattt taattttatt      780

ttggtatcaa gactatattg gcttcagtat ctattttcct ctggtcattt cagactctca      840

tctctctatt aaagtgaata ttctgtagat cagatgaatt atcatcggca ttaacgtcaa      900

gtacacacta ctgagagaga atttattctc tgtttaccac taattatctt ccccgcatgt      960

ctcttccttc tgttgttcta agcatctctt ctatactctg tgctgaaacg gatggaattc     1020

atggcttatg gaaatcaaat cccttttgaa ggactcagaa agactcacaa gaccttgatc     1080

attttctctg ggtttgggag tggagtatta tgtgactggg actccacaaa atatttatat     1140

tattttcaag acctattggg ggttttgttt tattttatct aatttttttt tttttttggt     1200

atactgagct tatagactat gagagaaaag tgagcaccaa aaacttcatt aatcacctta     1260

tcaggaagga atatcctgcc atagtaaaat tggctctgaa gagcttagag gcaagttaca     1320

caatgttttc ttgattacat ctgaagtctc ttctctttta agagcaaaga cattgtttca     1380

gtttctgaga gtggttagag gaaatttagg tacaatgcat gcatcacaga ctgtatttga     1440

ttgattcgag tcttcaaata ttgtttaatg gaatgatgag cctgcataaa gtgaagctgc     1500

aatgtaacat aggtatcttt ttctaaaaac ttcaagtgtt tgattaaaat agagaaaata     1560

atttttaaaa taatagataa aaattttaaa aacagccaga aaaagtataa tttatactgg     1620

ttagggttta agatggcatg gatttgacaa agataacaaa gacagaatca tctatatatt     1680

cattcattac gtgttactgt agtttattgg aatctgttaa tgccttcctc tagtagttaa     1740

aggtttatca gtatttctat tataaacctc tattttcagg ggtttcaatg tgcccttaaa     1800

attgtgctgg ggctgcagca aataaataat attgggactc atattcagtc tttggaacta     1860

gttttttttc catttaattt aaatgacaaa attgcatagg gataaatgta cagttttact     1920

aaggtttagc acctttgatc ttttctaaat caggaaaaaa atctatgcat attgaggttc     1980

acagatgaaa tattctttgg catactttgt agactttgac cacttaaaat actaagtggc     2040

caaatgataa aaaaaactgc tccctgcaca tgagtgtaaa aacatgtttg taattttaag     2100

taaaatggac tgatacccaa ataccacaga ctcacactat attacagaat gatgtaatac     2160

ctggtaattc tccagaagat agacttcaga cccttaatgc catttaaatg tagtttttgt     2220

ggtttaatct tatgagtaga ttgtaatgaa atcattacct ttgaaacatc aaacacttct     2280

ttaagctttt tttttttaat gtcatgaatc aggaaggata catagtgatt cgtatacaat     2340

tttgtctgca gcattcttga atatttttaa cactgtgtaa tccctgagca gcacaaaact     2400

tttattccga tgaccagtta cacaattcct gtttttattt tgtcctgttg tgctcatctt     2460

ctatgaaaaa taaatgatta ttaggc                                          2486


<210> 3855
<211> 6652
<212> DNA
<213> Homo sapiens

<400> 3855
taatgacgtc acgttgtttc gcgggagaaa ttcgaaagtg gattttgtgc aatttgacag       60

gtggtataaa tagttgaata tttcctattt tctggaccca gctggtttat aacttcagaa      120

gaaataatgg aaagccaaga atttattgtt ctatatactc atcaaaagat gaagaagtca      180

aaagtgtggc aagatggaat tctgaagatc actcacttag gaaacaaagc aattttatat      240

gatgacaaag gagcatgttt ggagagtctg tttcttaaat gccttgaggt gaaacctgga      300

gatgacttag aaagtgatcg atacttaatc acagttgaag aggttaaagt tgctggagcc      360

ataggtattg ttaagcagaa tgtcaataaa gaagcaccag agttaaattc aaggacattt      420

atatcctctg gccgatctct tggatgtcag ccctctggct taaaaaggaa gtttactggt      480

tttcaaggac cacgtcaggt tccaaagaaa atggttatta tggaaagtgg tgaatcagct      540

gcatcacatg aggctaagaa aactggccct actatttttt ctccattctg cagcatgcct      600

cctttgtttc ctactgttgg caagaaagat gtaaataata tactggcaga ccctgagaac      660

attgtgactt acaagaacag ggagagaaat gccatggatt tttcttcggt tttttctcca      720

tccttccaga ttaacccaga agtgctgtgt gaagaaaatt atttttgctc acctgtcaat      780

tctggaaata agctttcaga ctctttactg accaatgagc ctgtgaaaag agatagtttg      840

gcatctcact attcaggagt ttcacaaaac atcagaagca aagcacagat attagctctt      900

ctgaagtccg aatcatctag ttcatgtgag gaactaaatt ctgagatgac agagcatttt      960

cctcaaaaac aaccacaagg aagtttaaaa attgctacta aaccaaagta cctaattcaa     1020

caggaagagt gtgctgagat gaagagcaca gaaaatttat actaccagca tcaatcagaa     1080

aataccatga gaaataaaag ccggtgggcc atgtatttat cctcacagag ttcacctata     1140

cattcttcta ctgtagatgg gaatgataca gaaaggaaac ccaaggccca ggaagatgat     1200

gtaaattcta atttgaaaga cctttcatta caaaaaatta tacagttcgt tgaaacgtat     1260

gctgaagaga ggaaaaagta taatgtagac cagtcagtcg gtaataatga tccatcctgg     1320

aatcaggaag taaaattaga aattccttca ttcaatgaaa gcagtagctt acaggttact     1380

tgtagcagtg cagaaaatga tggtatatta tcagaatctg acattcaaga agataataaa     1440

atacctttta atcaaaatga caaggggtgc attaaaggat cagttctcat taaagaaaat     1500

gctcaggagg taaatacatg tggaacactg gaaaaggagt atgaacaatc agagtcatct     1560

ctgccagaac tgaaacatct ccaaattgaa tctagtaata attctaggat ctctgatgac     1620

attacagaca tgatttctga aagtaaaatg gataatgaaa gtcttaatag tattcatgaa     1680

tctctgagta atgtaacaca accatttttg gaggtaactt ttaatctgaa caattttgag     1740

accagtgaca ctgaggagga atcacaggaa agcaacaaaa tttcccagga ttcagagagt     1800

tgggtaaagg acattttggt taatgatggc aattcatgtt ttcaaaagag gtctgagaat     1860

acaaactgtg aagagattga gggtgaacat ttgccattct taacatctgt tagtgacaaa     1920

cctacagtga catttcctgt taaagagact ctgccatcac agttttgtga taaaacttat     1980

gtgggttttg acatgggaat atgtaaaact gaaaacacag gaaaagaaat agaggagtat     2040

agtgacacat taagcaattt tgaatctttc aagtggactg atgctgtata cggagataat     2100

aaagaagatg ctaataaacc tattcaagaa gtcagaatta actatgattt tgctttaccc     2160

ccgaataaat ctaaaggtat aaacatgaat ttacatattc ctcatattca aaaccagatt     2220

gctgaaaaca gtaatctatt ttcagaagat gctcaacctc agccttttat tttgggaagt     2280

gacttagaca aaaatgatga acatgtttta ccctcaactt ctagtagtga caacagtgtc     2340

caactattaa ataccaatca gaatcactat gaatgtattg cacttgataa atcaaatacc     2400

cacatttcca attctttgtt ttacccactg ggaaaaaagc atcttatttc caaagacaca     2460

gaagcacata tatctgaacc tgaagatttg ggaaagatta gaagtccacc ccctgaccat     2520

gttgaggttg aaactgccag agaaggcaaa caatactgga atcctagaaa ttcttcagaa     2580

ctttctggat tagtaaatac catttctatt ttaaagtcgc tatgtgaaca cagtactgct     2640

ttagacagct tggaaatatt gaaaaagaaa aatactgtct ttcagcaagg aactcaacag     2700

acgtatgagc cagatagccc tcctgaagtg aggaaaccat ttattacagt agtttcacca     2760

aagtctcctc atctgcacaa ggattctcaa cagatactaa aagaagatga agttgaacta     2820

agtgaaccac ttcagtctgt gcagttctct tcctcgggaa gtaaagaaga gactgctttt     2880

caagctgtta ttcctaaaca aatagagaga aaaacctgtg accctaagcc tgttgagttt     2940

caaggacatc aagtaaaagg atcagctact agtggtgtaa tggtcagagg acacagctca     3000

cagctaggat gcagtcagtt tccagatagc actgagtatg aaaactttat gacagagaca     3060

ccagagttac ctagcacgtg tatgcagatt gacttcttgc aggtgacatc accagaagaa     3120

aacatctcta cattgagccc tgtttctacc ttttctttga actcaagaga tgaagacttc     3180

atggtagaat tctctgagac gtccctgaaa gcaagaactt tacctgatga tcttcatttt     3240

ctcaacttgg aggggatgaa aaaatcccgt tctctggaga atgagaacct tcaaaggctt     3300

tcattattaa gtagaaccca ggttccactt attactttgc cacgtactga tgggccacct     3360

gacttagact ctcattcgta tatgatcaac tctaacacat acgagtcttc tggctccccc     3420

atgctcaatt tgtgtgaaaa gtcagcagtt ctttcgttta gcattgagcc tgaggaccaa     3480

aatgaaacct ttttctctga agaatctagg gaagtgaatc caggggatgt ttcacttaat     3540

aatatatcta ctcagagcaa gtggctgaaa tatcaaaaca catcccaatg caacgtggct     3600

actccaaaca gagttgataa gagaataact gatggcttct ttgctgaggc tgtttctggg     3660

atgcatttta gagacacaag tgaaagacag agtgatgctg tcaatgaaag ctctttagac     3720

tctgtgcatt tgcaaatgat aaaaggcatg ctctatcaac agcggcagga ttttagcagt     3780

caagattcgg tttccagaaa gaaagtactt tctctgaatt taaagcagac ttctaagaca     3840

gaggaaatta aaaatgtatt aggagggtct acctgctaca actacagtgt aaaggattta     3900

caggagataa gtggctctga gctgtgcttt ccaagtgggc agaaaataaa atctgcttat     3960

cttccccaaa ggcaaattca cataccagct gtttttcagt ctcctgctca ttataagcag     4020

actttcacat cttgcctcat agaacatcta aatatattgc tgtttgggtt agcacaaaac     4080

ctgcagaaag ctctttcaaa agttgacata tcattttata catcattgaa gggagagaaa     4140

ctgaaaaacg cagaaaataa tgtaccatcc tgccatcata gtcaacctgc aaaacttgtc     4200

atggttaaaa aggaaggtcc aaataagggt cgtctctttt atacatgtga tggacccaaa     4260

gctgatcgat gtaaattctt taaatggctt gaggacgtga ctccaggata ttcaacacag     4320

gaaggagctc gacctggcat ggttttaagt gatattaaga gtattggctt atatttaaga     4380

agtcaaaaga taccacttta tgaggaatgc cagcttttgg tgagaaaagg atttgatttt     4440

cagagaaaac agtatggcaa actaaagaag tttactactg taaatcctga gttttataat     4500

gaaccaaaaa ccaaacttta tcttaagcta agtcggaagg aaagatcttc agcttatagc     4560

aaaaatgatc tttgggtggt ttcaaaaacc ctagactttg agctggatac ttttatcgca     4620

tgtagtgctt tctttggacc atcatctatc aatgagatag aaatactgcc tttgaaaggc     4680

tatttccctt ctaattggcc cactaacatg gttgtccatg cgttattggt ttgtaatgct     4740

agcacagaac tgactacttt gaaaaacatt caggactact ttaatccagc tactctacct     4800

ctaacacagt acctgttaac aacgtcttcg ccaactatag ttagtaacaa aagagtcagt     4860

aagagaaaat ttatcccacc agccttcaca aatgtcagta caaaatttga actactcagc     4920

ctaggagcaa cattgaagtt agctagtgag ttgattcagg tacacaagtt aaacaaggat     4980

caagctacag ctctaattca aatagctcaa atgatggcat cacatgaaag cattgaagaa     5040

gtgaaggaac tgcaaactca taccttccct atcacaatca tacatggtgt gtttggagca     5100

ggaaagagtt acttgctggc agtggtgatt ttgttctttg tacagctgtt tgaaaagagt     5160

gaagctccca ccattggaaa tgcaaggccg tggaaacttc tgatttcttc ttctactaat     5220

gtggctgttg acagagtact tcttgggctt ctcagtcttg gatttgaaaa ctttatcaga     5280

gttgggagtg ttaggaagat tgccaaacca attttacctt atagcttgca tgctggctca     5340

gaaaatgaaa gtgaacagtt aaaagaacta catgcactaa tgaaagaaga cctgactcct     5400

acggaaagag tctatgtgag aaaaagcatt gagcagcata aactggggac caatagaacc     5460

ctgctgaagc aggttcgagt agttggagtt acctgtgcag cctgcccatt cccatgcatg     5520

aatgatctta aatttcctgt agttgtgctg gatgagtgta gtcagataac tgaaccggcc     5580

tctctccttc ccattgcaag gtttgagtgt gaaaagctga ttcttgttgg ggatcccaaa     5640

cagctacctc ctactattca gggttctgat gcagctcatg aaaatggatt ggaacaaact     5700

ctttttgatc gactttgctt aatgggtcac aagccaattc tattgagaac tcaataccgt     5760

tgtcatcctg caatcagtgc tattgctaat gatctgtttt acaaaggagc cctcatgaat     5820

ggtgtaacag aaatagagcg gagcccttta ttggaatggc taccaaccct gtgtttttat     5880

aatgttaaag gactagaaca gatagaaaga gataacagct ttcataatgt ggcagaagct     5940

acgtttacac tcaagctgat tcaatcactg attgcaagtg gaatagcagg ctctatgatt     6000

ggtgtgataa cattatacaa atcccagatg tacaagcttt gtcatttact cagtgctgtg     6060

gactttcacc atcctgatat taaaactgtg caggtgtcca cagtagatgc ttttcaggga     6120

gctgaaaagg agatcattat tctgtcctgt gtaaggacaa gacaagtagg attcattgat     6180

tcagaaaaaa gaatgaatgt tgcattgact agaggaaaga ggcatttgtt gattgtggga     6240

aatttagcct gtttgaggaa aaatcaactt tggggacgag tgatccaaca ctgcgaagga     6300

agggaagatg gattgcaaca tgcaaaccag tatgaaccac agctgaacca tctccttaaa     6360

gattattttg aaaaacaagt ggaagaaaaa cagaagaaaa agagtgaaaa agagaaatct     6420

aaagataaat ctcattcata aaaagacatg gtgtaaatat tttgtattta tgtaaattca     6480

gactcatttt acatgatata ttttttatat ttttattact ctaaaccctc ttattaaaaa     6540

tatgatattt aaataacata gtaaacacat gtaaaaattt tgttcttcaa aaaagtgtac     6600

aaaaggtagt ataaaatcct actaataaaa ataagctttt ttctaagaag aa             6652


<210> 3856
<211> 1304
<212> DNA
<213> Homo sapiens

<400> 3856
gtggaatgtg aggggaggtg gaggagatgg cggcgacggc ccgggaagat ggcgccagcg       60

gtcaagagcg aggtcagcgg ggctgcgagc actatgacag aggatgtctc ctaaaggcac      120

cttgctgtga caagctttat acttgccgct tgtgtcatga taacaatgaa gatcatcaac      180

tagatcgctt taaagtgaag gaagtgcagt gcataaactg tgaaaaaatt caacatgccc      240

aacagacttg tgaagaatgt agcacattgt ttggagaata ttattgcgat atatgccatt      300

tgtttgacaa agataagaag cagtatcact gtgaaaactg tggaatttgt aggattggtc      360

caaaggaaga ttttttccat tgtttgaaat gtaacttatg cctagctatg aatcttcaag      420

gaagacacaa gtgtattgaa aatgtgtccc gacagaattg tccaatatgt ttggaggaca      480

ttcacacatc ccgtgttgtt gctcatgtct tgccatgtgg acatctttta catagaacgt      540

gttatgaaga aatgttgaaa gaatatgacc aggtattgga gacagctgga tgatgaagta      600

gcacagactc ctatgccatc agaatatcag aacatgactg tggatattct ctgcaatgac      660

tgtaatggac gatccactgt tcagtttcat atattaggca tgaaatgtaa gatttgtgaa      720

tcctataata ctgctcaagc tggaggacgt agaatttcac tggatcagca atgacgagcc      780

tacacagtac tggagaactt ggcattttct gatatagaaa aaggctttcc ttggtatcgt      840

gttatcatgt gtcgtcatct atgcattaga gttgatgtgt tttgtactag tgtcacagca      900

taaaatcata ttacaagtac gtaaggattc agggtctctt gatagactta tcatagctct      960

atattgaatg aaagccactg tgcttgtgtt ttgattggaa attcctttag tgtcagtttt     1020

ttggaagcca atgatgtttg ccactgatac attcatagaa gtgtattata ttttcatgaa     1080

gctttgcttt aagtgacact acgcgtgcag ttcatttcta gttcttgata gaactgcact     1140

taattttcag tagtagtctt gactttttaa gggctgtgtt atattaagtt ctcccttact     1200

gttaaaacct aattaaatat gctttagaat tttctaagac agtcctctgg atcctctaaa     1260

tgtgaatttt gatgtaataa ctgctaataa aattatattg aaac                      1304


<210> 3857
<211> 600
<212> DNA
<213> Homo sapiens

<400> 3857
attcgctata gattccttgt ttctcacttc gtagcacgag ccactctgac catcaagatc       60

agaaaaactt ctcagctgca agttagaagt ggactggcca ttgaggaggc tctcagcgga      120

gtcgctcttc acaggagtct tgaacgcggt gtggaatcgg cagcgaggaa tcctggagca      180

cagagaagct cccagctttg aaggtcttgc ggtggtgaaa aattagacga tttcaagaat      240

tggagctgaa tctgatgtta agtaatggca acaggtgact taaaaagaag cttacggaac      300

ctagaacagg tgctccgctt gctaaattat cctgaagagg tggactgtgt aggtttgata      360

aagggagacc cagcagcatc tttgcccatc atcagctatt cttttacctc atactcacct      420

tatgtaacag aacttataat ggaatccaat gtagagctca tagcaaaaaa tgacttgcgc      480

tttatagatg ctgtctataa gcttcttcgt gatcaattta attataaacc aattttgaca      540

aaaaagcagt ttatccaatg tgggtttgca gaatggaaaa tccaaattgt ttgtgatatt      600


<210> 3858
<211> 713
<212> DNA
<213> Homo sapiens

<400> 3858
aacagccaga ggccactggt gtataggatc ctcctactct ctgacttttt ttcttgtagt       60

tattttgagg ccctgtcccg tggagagacg cctccggtga gagagcggtc tgagcgagtc      120

gctttgtgta actgggcaga gctaacacct gagctgttaa agatcctgca ttctcaggtt      180

gctggcagac tgatcatccg tgcagaggag ctggcccaga tgtggaaagt ggtgaatctc      240

ccaacagatc tgtttaatag tgtgatgaat gtgggtcgct tcacggagga gatcgagtgg      300

ctgaagtttt tagcccttgc ttgcagcgct ctgggagtta ctattaccaa aactctcaag      360

atagtgtgtg aggtcttatc atgtgaccac aatggtgggt tgccccgaat cccattcagc      420

accttccagt ttctctacac gtatattgcc gaagtggatg gggagatctg tgcatcacat      480

gtcagcagga tgctaaacta cattgaacag gaagtaattg gtcctgatgg tttaatcacg      540

gtgaatgact ttacccaaaa ccccagggtt tggctggagt aacagcacaa ttttggcaat      600

tttaaaggaa gatacagagg tgattgtact tcagaatgat aaacccatat accacctaaa      660

atcaattttc ttgtacaact ggtacacact aataaacaaa catgtgagat cag             713


<210> 3859
<211> 2789
<212> DNA
<213> Homo sapiens

<400> 3859
agaaagctcc gcagttcttg agttccacat gcagagcaga tgcgacagct agaagtgagt       60

agggcccaga ccctggccca ggaagatcca ctaaaggagg ccatccttcc gccttcttct      120

gcaggagtca ggatggaaag gcagatgtaa agtccctcat ggcgaaatat aacacggggg      180

gcaacccgac agaggatgtc tcagtcaata gccgaccctt cagagtcaca gggccaaact      240

catcttcagg aatacaagca agaaagaact tattcaacaa ccaaggaaat gccagccctc      300

ctgcaggacc cagcaatgta cctaagtttg ggtccccaaa gccacctgtg gcagtcaaac      360

cttcttctga ggaaaagcct gacaaggaac ccaagccccc gtttctaaag cccactggag      420

caggccaaag attcggaaca ccagccagct tgaccaccag agaccccgag gcgaaagtgg      480

gatttctgaa acctgtaggc cccaagccca tcaacttgcc caaagaagat tccaaaccta      540

catttccctg gcctcctgga aacaagccat ctcttcacag tgtaaaccaa gaccatgact      600

taaagccact aggcccgaaa tctgggccta ctcctccaac ctcagaaaat gaacagaagc      660

aagcgtttcc caaattgact ggggttaaag ggaaatttat gtcagcatca caagatcttg      720

aacccaagcc cctcttcccc aaacccgcct ttggccagaa gccgccccta agtaccgaga      780

actcccatga agacgaaagc cccatgaaga atgtgtcttc atcaaaaggg tccccagctc      840

ccctgggagt caggtccaaa agcggccctt taaaaccagc aagggaagac tcagaaaata      900

aagaccatgc aggggagatt tcaagtttgc cctttcctgg agtggttttg aaacctgctg      960

cgagcagggg aggcccaggt ctctccaaaa atggtgaaga aaaaaaggaa gataggaaga     1020

tagatgctgc taagaacacc ttccagagca aaataaatca ggaagagttg gcctcaggga     1080

ctcctcctgc caggttccct aaggcccctt ctaagctgac agtggggggg ccatggggcc     1140

aaagtcagga aaaggaaaag ggagacaaga attcagccac cccgaaacag aagccattgc     1200

ctcccttgtt taccttgggt ccacctccac caaaacccaa cagaccacca aatgttgacc     1260

tgacgaaatt ccacaaaacc tcttctggaa acagtactag caaaggccag acgtcttact     1320

caacaacttc cctgccacca cctccaccat cccatccggc cagccaacca ccattgccag     1380

catctcaccc atcacaacca ccagtcccaa gcctacctcc cagaaacatt aaacctccgt     1440

ttgacctaaa aagccctgtc aatgaagaca atcaagatgg tgtcacgcac tctgatggtg     1500

ctggaaatct agatgaggaa caagacagtg aaggagaaac atatgaagac atagaagcat     1560

ccaaagaaag agagaagaaa agggaaaagg aagaaaagaa gaggttagag ctggagaaaa     1620

aggaacagaa agagaaagaa aagaaagaac aagaaataaa gaagaaattt aaactaacag     1680

gccctattca agtcatccat cttgcaaaag cttgttgtga tgtcaaagga ggaaagaatg     1740

aactgagctt caagcaagga gagcaaattg aaatcatccg catcacagac aacccagaag     1800

gaaaatggtt gggcagaaca gcaaggggtt catatggcta tattaaaaca actgctgtag     1860

agattgacta tgattctttg aaactgaaaa aagactctct tggtgcccct tcaagaccta     1920

ttgaagatga ccaagaagta tatgatgatg ttgcagagca ggatgatatt agcagccaca     1980

gtcagagtgg aagtggaggg atattccctc caccaccaga tgatgacatt tatgatggga     2040

ttgaagagga agatgctgat gatggctcca cactacaggt tcaagagaag agtaatacgt     2100

ggtcctgggg gattttgaag atgttaaagg gaaaagatga cagaaagaaa agtatacgag     2160

agaaacctaa agtctctgac tcagacaata atgaaggttc atctttccct gctcctccta     2220

aacaattgga catgggagat gaagtttacg atgatgtgga tacctctgat ttccctgttt     2280

catcagcaga gatgagtcaa ggaactaatg ttggaaaagc taagacagaa gaaaaggacc     2340

ttaagaagct aaaaaagcag gaaaaagaag aaaaagactt caggaaaaaa tttaaatatg     2400

atggtgaaat tagagtccta tattcaacta aagttacaac ttccataact tctaaaaagt     2460

ggggaaccag agatctacag gtaaaacctg gtgaatctct agaagttata caaaccacag     2520

atgacacaaa agttctctgc agaaatgaag aagggaaata tggttatgtc cttcggagtt     2580

acctagcgga caatgatgga gagatctatg atgatattgc tgatggctgc atctatgaca     2640

atgactagca ctcaactttg gtcattctgc tgtgttcatt aggtgccaat gtgaagtctg     2700

gattttaatt ggcatgttat tgggtatcaa gaaaattaat gcacaaaacc acttattatc     2760

atttgttatg aaatcccaat tatctttac                                       2789


<210> 3860
<211> 1091
<212> DNA
<213> Homo sapiens

<400> 3860
gagccgatgc ccgattccgc gcccgccatg gccgacaaaa tggacatgtc tctggacgac       60

atcattaaac tgaaccggag ccagcgaggc ggccggggcg ggggccgggg ccgcggccgg      120

gccggctccc agggcggccg cggcggtggg gcgcaggccg ccgcgcgagt gaatcgaggc      180

ggcgggccca tccggaaccg gccggccatc gcccgcggcg cggccggcgg aggcggcagg      240

aaccgaccgg cgccctacag caggccaaaa caacttcccg acaagtggca gcacgatctt      300

ttcgacagtg gcttcggcgg tggtgccggc gtggagacag gtgggaaact gctggtgtcc      360

aatctggatt ttggagtctc agacgccgat attcaggaac tctttgctga atttggaacg      420

ctgaagaagg cggctgtgca ctatgatcgc tctggtcgca gcttaggaac agcagacgtg      480

cactttgagc ggaaggcaga tgccctgaag gccatgaagc agtacaacgg cgtccctctg      540

gatggccgcc ccatgaacat tcagcttgtc acgtcacaga ttgacgcaca gcggaggcct      600

gcacagagcg taaacagagg tggcatgact agaaaccgtg gcgctggagg ttttggtggt      660

ggtggaggca cccggagagg cacccgcgga ggcgcccgtg gaagaggcag aggtgccggc      720

aggaattcaa agcagcagct ttcggcagag gagctggatg cccagctgga cgcctataat      780

gcgagaatgg acaccagtta aacagaccag caaatccgcg tgcggaacag gacccaggcg      840

tctcctcttg ctccctggtt ggggggcggt ggctggggct gtgcggccaa tgatggattt      900

gtttctttta tgttttaaaa taggatttaa aaactcatgt aaaggttttt tttttttctt      960

tttttttttt tttaattctg aaacagacct gttttgtacc gagttatttt tgggataaat     1020

tttactggtt gctgttgtgg agaaggtggc gtttccacct tttccataat aaaatagaaa     1080

tgtgtgtaga a                                                          1091


<210> 3861
<211> 498
<212> DNA
<213> Homo sapiens

<400> 3861
gttgtagcag agcctagcta attacccttc ataattagaa ttgtcctatc tactacggag       60

tgttatagac cctctttcca caggagggga agaaagaaag aagccggaat ccccctgcca      120

tcctatgtct ttgcattatt gcctcactac cacatatgat cttcagaaga aaacctgaac      180

ctgctgacat ggccaagcat ggagccgacg agccatcctc caggtcaggg agtccggaca      240

gggaaggtag ggcctctgag gacagatcgc tgcttcatca gaggctggct gtccgggagc      300

tcatcgacac tgaggtctcc tacttgcaca tgctccagct ctgtgcctct gacatcagga      360

gccgcctcca gcagttgccg cagggagatc tggatgtcct gttctcaaac attgatgata      420

tcatcaaagt gaacagcaga ttcctccatg atctgcagga gacagcctcc aaggaagagg      480

aacaagtgca gctagttg                                                    498


<210> 3862
<211> 1155
<212> DNA
<213> Homo sapiens

<400> 3862
acgcctggtg aatggacgca ctcttaccaa ttctgctctg ggagatgcag cggtaaccta       60

ccgagcgcag aggccggcgc gcacccgtgg agcccgcgct cgcgatccct cctcgtgcca      120

gggccccagg gcagtcaagg cctgccgacc gttaggcggg tcaaggggta cacagggtgc      180

gaattcgtta ggcaaaagct gggtacaggc gcgagccaca ggcacggaaa cctcgcgccg      240

accggggccc taggcccgac gacggcaggt aaggggaagt ggaggcacac agggctggga      300

cgtgccccag gcaccatacg ggtggcttcg ggcgcgggac gtccgcagcc ccgcagctcc      360

caggacgttc gacaatctgc agctgaccag cttcggccgg tttggggata aagggaagac      420

aggcggcgcg gggagtggga acgcctgaag gccgcgcccc tcctttcagg tcggccagga      480

gcgcgccgtt tgtttcgacg ccggaccgcg taagagacga tgatgttggg cacggaaggt      540

ggagagggat tcgtggtgaa ggtccggggc ttgccctggt cttgctcggc cgatgaagtg      600

cagaggtttt tttctgactg caaaattcaa aatggggctc aaggtattcg tttcatctac      660

accagagaag gcagaccaag tggcgaggct tttgttgaac ttgaatcaga agatgaagtc      720

aaattggccc tgaaaaaaga cagagaaact atgggacaca gatatgttga agtattcaag      780

tcaaacaacg ttgaaatgga ttgggtgttg aagcatactg gtccaaatag tcctgacacg      840

gccaatgatg gctttgtacg gcttagagga cttccctttg gatgtagcaa ggaagaaatt      900

gttcagttct tctcagggtt ggaaatcgtg ccaaatggga taacattgcc ggtggacttc      960

caggggagga gtacggggga ggccttcgtg cagtttgctt cacaggaaat agctgaaaag     1020

gctctaaaga aacacaagga aagaataggg cacaggtata ttgaaatctt taagagcagt     1080

agagctgaag ttagaactca ttatgatcca ccacgaaagc ttatggccat gcagcggcca     1140

ggtccttatg acaga                                                      1155


<210> 3863
<211> 1244
<212> DNA
<213> Homo sapiens

<400> 3863
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg aatttcccac      120

ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat cccagcatgt      180

ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag gaggctgcag      240

ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt tctgaaggag      300

aactagatca gttggctcag attcggccat taatattcaa ttttcatgag cagacagcca      360

tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc atgcaggaat      420

ttatggcttt agaacttaag aatctgcctg gtgagttcaa ctctgggaat caaccaagca      480

acagagaaaa aaacagatac cgagatattc ttccatatga ttcaacacgc gttcctcttg      540

gaaaaagcaa ggactacatc aatgctagtt atattagaat agtcaattgt ggagaagagt      600

atttttatat cgctactcaa ggaccactgc tgagcaccat agatgacttt tggcaaatgg      660

tgttggaaaa taattcaaat gttattgcca tgataaccag agagatagaa ggtggaatta      720

tcaaatgcta ccattactgg cccatttctc tgaagaagcc attggaattg aaacacttcc      780

gtgtattcct ggagaactac cagatacttc aatatttcat cattcgaatg tttcaagttg      840

tggagaagtc cacgggaact agtcactctg taaaacagtt gcagttcacc aagtggccag      900

accatggcac tcctgcctca gcagatagct tcataaaata tattcgttat gcaaggaaga      960

gccaccttac aggacccatg gttgttcact gcagtgccgg cataggccgg acaggggtgt     1020

tcctatgtgt ggatgtcgtg ttctgtgcca tcgtaaagaa ctgttcattc aacatcatgg     1080

atatagtggc ccaaatgaga gaacaacgtt ctggcatggt tcaaacgaag gagcagtatc     1140

acttttgtta cgatattgtg cttgaagttc ttcggaaact tctgactttg gattaagaaa     1200

gacttctgtt gcctctcact tgaaattacc aagtgggttt gcac                      1244


<210> 3864
<211> 3305
<212> DNA
<213> Homo sapiens

<400> 3864
gtggcggggg cgtggccatg gcgggggcgc tccggcgggg gcgggccctg ggctcccgcc       60

cttcgggtcc cacagtttcc agccgccgct ctcctcagtg cccggtggcc caggagggcc      120

tgggagcccg aagccgtccc cgagtcgctc ctaggtcact ggcgcgatgc gggccgtcct      180

ctcggctgat gggttggaag cccagcgagg ctagaggcca gtcccaaagt ttccaggcat      240

cagggctgca gcccaggagc ctcaaggcgg cccggcgggc gactggacgg ccggacaggt      300

cccgagcagc ccggcccacc atggacccct ctgcccacag gtcccgagca gccccgccca      360

acatggaccc agacccccag gcgggcgtgc aggtgggcat gcgggtggtg cgcggcgtgg      420

actggaagtg gggccagcag gacggcggcg agggcggcgt gggcacggtg gtggagcttg      480

gccgccacgg cagcccctcg acacccgacc gcacagtggt cgtgcagtgg gaccagggca      540

cgcgcaccaa ctaccgcgcc ggctaccagg gcgcgcacga cctgctgctg tacgacaacg      600

cccagatcgg cgtccggcac cccaacatca tctgtgactg ctgcaagaag cacgggctgc      660

gggggatgcg ctggaagtgc cgtgtgtgcc tggactacga cctctgcacg cagtgctaca      720

tgcacaacaa gcatgagctc gcccacgcct tcgaccgcta cgagaccgct cactcgcgcc      780

ctgtcacact gagtccccgc cagggcctcc cgaggatccc actaaggggc atcttccagg      840

gagcgaaggt ggtgcgaggc cccgactggg agtggggctc acaggatgga ggggaaggga      900

aaccgggccg tgtggtggac atccgtggct gggatgtgga gacaggccgg agtgtggcca      960

gcgtgacgtg ggctgatggt accaccaatg tgtaccgtgt gggccacaag ggcaaggtgg     1020

acctcaagtg tgtgggcgag gcagcgggcg gcttctacta caaggaccac ctcccaaggc     1080

tcggcaagcc ggcggagctg cagcgcaggg tgagtgctga cagccagccc ttccagcacg     1140

gggacaaggt caagtgtctg ctggacactg atgtcctgcg ggagatgcag gaaggccacg     1200

gcggctggaa ccccaggatg gcggagttta tcggacagac gggcaccgtg catcgtatca     1260

cggaccgcgg ggacgtgcgc gtgcagttca accacgagac gcgctggacc ttccaccccg     1320

gggcgctcac caagcaccac tccttctggg tgggcgacgt ggtccgggtc atcggcgacc     1380

ttgacacagt gaagcggctg caggctgggc atggcgagtg gacggacgac atggcccctg     1440

ccctgggccg cgtcgggaag gtggtgaaag tgtttggaga cgggaacctg cgtgtagcag     1500

tcgctggtca gcggtggacc ttcagcccct cctgcctggt ggcctaccgg cccgaggagg     1560

atgccaacct ggacgtggcc gagcgcgccc gggagaacaa aagctcactg agcgtggccc     1620

tggacaagct tcgggcccag aagagtgacc cagagcaccc gggaaggctg gtggtggagg     1680

tggcgctggg taacgcagcc cgggctctgg acctgctgcg gaggcgccca gagcaggtgg     1740

acaccaagaa ccaaggcagg accgctctgc aagtggctgc ctacctgggc caggtggagt     1800

tgatacggct gctgctacaa gccagggcgg gcgtggacct gccggacgac gagggcaaca     1860

cggcactgca ctacgcggcc ctggggaacc agcccgaggc caccagggtg ctcctgagtg     1920

ctgggtgccg ggcggacgcc atcaacagca cccagagcac agcactgcac gtggccgtgc     1980

agaggggctt cctggaggtg gtgcgggccc tgtgtgagcg cggctgtgac gtcaacctgc     2040

ccgacgccca ctcggacacg cccctgcact ccgccatctc ggcgggcact ggagccagcg     2100

gcattgtcga ggtcctcacg gaggtgccaa acatcgatgt taccgccacc aacagccagg     2160

gtttcaccct gctgcaccat gcctccctca agggtcacgc gctagctgtg agaaagattc     2220

tggctcgggc gcggcagctg gtggacgcca agaaggagga cggcttcacg gcgctgcatc     2280

tggctgccct caacaaccac cgcgaggtgg cccagatcct catccgggag ggccgctgtg     2340

acgtgaacgt gcgcaaccgg aagctgcagt ccccgctgca tctcgccgtg caacaggccc     2400

acgtggggct ggtgccgcta ctggtggacg ctgggtgcag tgtcaacgcc gaggacgagg     2460

agggggacac agccctgcac gtggcgctgc agcgtcatca gctgctgccc ctggtggctg     2520

atggggccgg gggggaccca gggcccttgc agctgctgtc caggctacag gcctcgggcc     2580

tccccggcag cgcggagctg acggtgggcg cggcggtcgc ctgcttcctg gcgctggagg     2640

gcgccgacgt gagctacacc aaccaccgcg gtcggagccc gctggacctg gccgccgagg     2700

gtcgcgtgct caaggccctt cagggctgcg cccagcgctt ccgggagcgg caggcgggcg     2760

ggggcgcggc cccgggcccc aggcaaacgc tcgggacccc caacaccgtg acgaacctgc     2820

acgtgggcgc cgcgccgggg cccgaggccg ctgagtgcct ggtgtgctcc gagctggcgc     2880

tgctggtgct gttctcgccg tgccagcacc gcaccgtgtg tgaggagtgc gcgcgcagga     2940

tgaagaagtg catcaggtgc caggtggtcg tcagcaagaa actgcgccca gacggctctg     3000

aggtggcgag cgccgccccc gcccccggcc cgccgcgcca gctggtggag gagctgcaga     3060

gccgctaccg gcagatggag gaacgcatca cctgccccat ctgcatcgac agccacatcc     3120

gcctcgtgtt ccagtgcggc cacggcgcat gcgccccctg cggctccgcg ctcagcgcct     3180

gccccatctg ccgccagccc atccgcgacc gcatccagat cttcgtgtga gccgcgccgt     3240

ccgccgcgcc cgagctgcct tcgcgtgccc ccgccctgtg ttttataaaa agaaagattc     3300

tcgga                                                                 3305


<210> 3865
<211> 2044
<212> DNA
<213> Homo sapiens

<400> 3865
gtctcctcgc tgtcgccgcc gctgccacac catggccttc gtcaccaggc agttcatgcg       60

ttccgtgtcc tcctcgtcca ccgcctcggc ctcggccaag aagataatcg tcaagcacgt      120

gacggtcatc ggcggcgggc tgatgggcgc cggcattgcc caggaaagag gttggcctca      180

gcagcaatga gggataattc tttcaagaaa ggaatgaaga gagaagttag atggaaaaga      240

gatttttaag gtcaaaagaa gcagctgaag aacatgtgta ggacagcctt aggagttact      300

acacttcaag acctgggtgt ctgctggagg aaggaacatg accctgcgga gatgttaagg      360

gttgggagag ctgagcttgg aggctggaag cccagctggg aggctattgt taaagaggtt      420

gctgcagcaa ctggtcacac agtagtgttg gtagaccaga cagaggacat cctggcaaaa      480

tccaaaaagg gaattgagga aagccttagg aaagtggcaa agaagaagtt tgcagaaaac      540

cttaaggccg gcgatgaatt tgtggagaag accctgagca ccatagcgac cagcacggat      600

gcagcctccg ttgtccacag cacagacttg gtggtggaag ccatcgtgga gaatctgaag      660

gtgaaaaacg agctcttcaa aaggctggac aagtttgctg ctgaacatac aatctttgcc      720

agcaacactt cctccttgca gattacaagc atagctaatg ccaccaccag acaagaccga      780

ttcgctggcc tccatttctt caacccagtg cctgtcatga aacttgtgga ggtcattaaa      840

acaccaatga ccagccagaa gacatttgaa tctttggtag actttagcaa agccctagga      900

aagcatcctg tttcttgcaa ggacactcct gggtttattg tgaaccgcct cctggttcca      960

tacctcatgg aagcaatcag gctgtatgaa cgaggtgacg catccaaaga agacattgac     1020

actgctatga aattaggagc cggttacccc atgggcccat ttgagcttct agattatgtc     1080

ggactggata ctacgaagtt catcgtggat gggtggcatg aaatggatgc agagaaccca     1140

ttacatcagc ccagcccatc cttaaataag ctggtagcag agaacaagtt cggcaagaag     1200

actggagaag gattttacaa atacaagtga tgtgcagctt ctccggctct gagaagaaca     1260

cctgagagcg ctttccagcc agtgccccga gtgcctgtgg gaatgctctt tggtcagaca     1320

ttccctcaca cagtacagtt taataaatgt gcattttgat tgtaatctat cgaagtgatt     1380

attacaccag ttacagcagt aatagattct ccattaagaa ataattccct tttttagtct     1440

gttcatttct gtgtattttc taaacagctt tacacccttg gtgccttgga gcaaacatgt     1500

tttttgaacc ttgtcatttt tgtgaagaat tgcctagatt ccttctctca tcaacgggaa     1560

agtacttcct ctgagagtgc gagtgcacca tgctcactgt tgctgcgtgg gagagtcaca     1620

agccactggc aagcaagtgg tatagtctgt gaagcactgc agcgagcagc acctggatct     1680

tgcctttata agaacatttt actacctgca gctttgagtc ttgccctaca ttttgggcat     1740

gacataagat gtgtctttat tcagctcgtc gtgaagatgc tgctgctgaa tgggtcagca     1800

tatctctgtt tgcatggttt gcaggaggtc ggttttcatg gtcattcagt tccacagatc     1860

tgaatgatta ctgtctgtct gtgtcttttt tccatgagaa atcactgttg caaattgcct     1920

ataaattgac tctactaaaa taacaatgtt tcagtctgaa aatttgaatt gaaaaaaatg     1980

tataatataa aattgtaata cactcaaatg attataaaag taaaagttgg taatttaggc     2040

agaa                                                                  2044


<210> 3866
<211> 2302
<212> DNA
<213> Homo sapiens

<400> 3866
aaggatctgc ttagaaacca aagctccagc cgagtgtttc ttttccccta catttttagt       60

gattcccttc tgttgatgcc tttgaaagct cggagaaata aatacgttta ttgttatgct      120

gttagaaaac aagttcatgc ttgtcctcta aagataagtg gtcttttcat tctacttttt      180

gttttgtagt aagagccata aaatttgcaa tcgcaagttt atgttgttat acttagttac      240

ccaaggggta gttttaagca tttttattca tatgaatatt tgaatataaa tgtgtgttca      300

aatatataga atcgttctta tattccacat ttttaatatt taaactattc acaatatctt      360

ttaatgatgt ttaaagaacg gcagtgtaga gatactgttg tcagatttgt gaggtgagca      420

cacgttgata ttgccagttt cgcttttgtt tatcaattca ataagcactg ctttttaaaa      480

cacgtgttga agcttcaggt ttgcacagaa gttcattttc aggaattcct aactaataaa      540

gggtatcaga cacgttctta cagttttgaa cataaatact gcagttagca tatgtagtgg      600

gatatttgtg tggtgaaagt gcctccatat ttcatatctt ttctttgaaa caagattctg      660

ttcagtatgc attaagtggt agttattttt taacttcctg ttacatacgt aaatttcata      720

aggaaaggaa atttggggag tcgttacagc ttttctccct ttaatcacag cgtacctgtc      780

cattgctcac attgttttca gaaaaaaaag ttgtatctca gctggatatc tgacttgact      840

ttagtaatgg gcctagaaac tataaactga acaaagctta taatgcacaa aaacaggata      900

agtacatttg ggggacaata tcttactggc aagtaactgg agtttcacca ggcgtgtagc      960

aggtgggatc aattttctaa aacggaagat gatctaagat gcatatttta taggcgttct     1020

cctaagcagt gctaattcta catgttttaa ttgctggtag atgcgtttcc agaacgagga     1080

tgccatttac agcgagtgtt aaaaaaaacg ttggatgatg aaatacacat tgcagaaaaa     1140

ggatgaagtt gaccagtgaa aagttgccca agaacccctt ttatgcctct gtatctcagt     1200

atgctgctaa aaaccaaaaa tttttccagt ggaaaaagga aaagactgat tacacccatg     1260

ctaatttggt ggataaggca ttgcagctct tgaaggaaag aatactgaaa ggagacactc     1320

tggcatattt cctacgaggt caactatatt ttgaagaggg atggtatgaa gaagcattag     1380

aacagtttga agaaatcaag gagaaagacc atcaagcaac ttaccagcta ggagtgatgt     1440

actatgatgg gctggggacc actctagacg ctgagaaagg ggtggactat atgaagaaaa     1500

ttcttgattc tccatgtccc aaagcaagac acttaaaatt tgcagctgct tacaacctcg     1560

gaagagctta ttatgaagga aaaggtgtta aacgatcaaa tgaggaagct gaaagactgt     1620

ggcttatcgc agcagacaat ggaaatccca aagctagtgt gaaggctcaa agtatgctcg     1680

ggctgtatta ctcaaccaag gagcccaagg agttagaaaa ggcattttac tggcattccg     1740

aagcatgtgg caatgggaat ctggagtccc agggtgcact tgggctcatg tacttgtatg     1800

gacaaggcat ccggcaggat acggaagctg ccctgcagtg cttaagagaa gcagcagaac     1860

gcggaaacgt ctatgctcaa gggaatctcg tggagtatta ctataagatg aaatttttta     1920

caaagtgtgt tgcattttcc aaaaggatcg ctgactatga tgaggttcac gacatcccca     1980

tgatcgccca ggtcacagac tgtctcccgg agttcatcgg cagaggcatg gcaatggcat     2040

ccttctacca cgcaaggtgt cttcagcttg gcttgggcat caccagggat gaaacaaccg     2100

ctaaacacta ttattctaaa gcttgtcgtc tgaatcccgc attggcagat gaacttcact     2160

ccttacttat tcgtcaaaga atttagacca caatgtattt caacaaagat catcaatgct     2220

aacacctcac aatgtgtgta tttttacagt agctatgttt ggttattttg cacatcacaa     2280

attacactat cctgggtatt tt                                              2302


<210> 3867
<211> 1945
<212> DNA
<213> Homo sapiens

<400> 3867
ctctcgtgga gtccgagcag ctgcttcagg gaggcccggg agcccctagg gcgggcagcc       60

ccggagcctg cagctgcgac gcagactcgg aaactacaac tgcgcgtgaa gccgactaaa      120

gttaacgcct gtgtgattga gtcagaagct ccttcaggaa cacaggagtg gggccgactc      180

ctggaatccg gccccgggtc gcttataaat gcgccaagaa aaaaacgtca cccagtaatt      240

ttttttctca tatgtagata caaaaggata ttcttaaaat ttttatagag acagggtctt      300

gctgtgttac ccaggctggt ctcacactcc tggcctcaag tgaccctcct gtctcagcct      360

cccaaagtgc taggattata ggcgtgaacc accacgccca gctggttcct gaggaagtca      420

gtgtgggaat actttttttt tttttatacg gagtctcgct ctgtcaccca ggctggagtg      480

cagtggcacg atctcggctc actgcaagct ccatctccca ggttcacgcc attctcccgc      540

ctcaacctcc cgagtagctg ggactacagg tacccaccac cacgcccagc taattttgtt      600

tgtgtatttt tagtagagac gggatttcac tgtgttagcc aggatggtct ggatctcctg      660

accttgtgat ctgcctggct cagcctccca aagtgctggg attacaggca tgagccacca      720

tgcccagccc actgtgggaa tacttgtgtt gagcacttgc tgtgtgttct gaataggaca      780

accagggtcc accccttctc tctgggcttg ttgagaagag gggtgcccag cctgacagtg      840

atgggacagg gaggcttcag tgccatttgg ccatgtgagc agtgttagtc tgaggtacac      900

atcatattgc ctacagcctt ctttcctgtg tgtctgttaa catttccaaa cctacactcc      960

gtgacatcca gcctcacagc ttacatcaca gcttaatgtc ctggcattta agagacccag     1020

cgttctgttt tccccgcagt aagctgcaca tagtcatagc gaatttggga aagatggaag     1080

gaatcatcca gcctcgcggt tcagagccca gctctgccac tgtcagccat gcaagcctca     1140

gttttcccat ctgtaacatg gggagaacag cactgctcag cccagagggc cactgcagag     1200

attctgagag agaacgtagg aagcgctgct cggcacgacc tgcacacggg gaggcctggc     1260

gctgcagcgg gcaccctcat caccataggg aaggcccagc tgcctccggg gaggcccgtt     1320

ctcctaggca gggtgttgga aaggggttgg cctctctgct gctttctggg agagccaagg     1380

ccacccctct ggggtactga cagggcatgc cttgtctcca gtggttcccc aggtggggcc     1440

ctgccctacc ctctcctctg acctccactc actcatccct ttggcccaca ggtacatgtg     1500

gggggcagcc tggccgtcct tggggggaag ctgtacgtct ctgggggata cgacaataca     1560

tttgaactct cggacgtggt agaggcctat gacccagaga ctcgcgcgtg gagcgtggtg     1620

gggcggctcc cagaacccac cttctggcat ggcagtgtca gcatcttccg ccagttcatg     1680

ccccagacct tctcgggtgg gcgtggcttc gagttggaca gtggcagcga tgacatggac     1740

ccaggccgac cccggccgcc gcgggacccc gatgagctgc actagcccca gtctggcccg     1800

gcacgggcct cggtgcaggt aactggcacc tctgcggggc agtgccccac tcctttgtgc     1860

acaaggacac gttgggctca caggaggagc acaggctctt gggtggcgaa gccagcccag     1920

gatccattac ctggaaggtt tctgt                                           1945


<210> 3868
<211> 1401
<212> DNA
<213> Homo sapiens

<400> 3868
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtgaacaa aaattgtttg ctggccccca ggatactaac tagacctttg gcctgactca      120

caggacacta aggctccttt tctgaagaag ccttttacca gtctcattta ggggatggga      180

acaacatgtc ttcacctagg gactttagag cagagcctgg tttttgaaaa taaagttaat      240

tcagagaagg taaaactttc tcttcggaat ttcccacata atgattatga ggatgttttt      300

gaagagcctt cagaaagtgg cagtgatccc agcatgtgga cagccagagg ccccttcaga      360

agagacaggt ggagcagtga ggatgaggag gctgcagggc catcacaggc tctctcccct      420

ctactttctg atacgcgcaa aattgtttct gaaggagaac tagatcagtt ggctcagatt      480

cggccattaa tattcaattt tcatgagcag acagccatca aggattgttt gaaaatcctt      540

gaggaaaaaa cagcagcgta tgatatcatg caggaattta tggctttaga acttaagaat      600

ctgcctggtg agttcaactc tgggaatcaa ccaagcaaca gagaaaaaaa cagataccga      660

gatattcttc catatgattc aacacgcgtt cctcttggaa aaagcaagga ctacatcaat      720

gctagttata ttagaatagt caattgtgga gaagagtatt tttatatcgc tactcaagga      780

ccactgctga gcaccataga tgacttttgg caaatggtgt tggaaaataa ttcaaatgtt      840

attgccatga taaccagaga gatagaaggt ggaattatca aatgctacca ttactggccc      900

atttctctga agaagccatt ggaattgaaa cacttccgtg tattcctgga gaactaccag      960

atacttcaat atttcatcat tcgaatgttt caagttgtgg agaagtccac gggaactagt     1020

cactctgtaa aacagttgca gttcaccaag tggccagacc atggcactcc tgcctcagca     1080

gatagcttca taaaatatat tcgttatgca aggaagagcc accttacagg acccatggtt     1140

gttcactgca gtgccggcat aggccggaca ggggtgttcc tatgtgtgga tgtcgtgttc     1200

tgtgccatcg taaagaactg ttcattcaac atcatggata tagtggccca aatgagagaa     1260

caacgttctg gcatggttca aacgaaggag cagtatcact tttgttacga tattgtgctt     1320

gaagttcttc ggaaacttct gactttggat taagaaagac ttctgttgcc tctcacttga     1380

aattaccaag tgggtttgca c                                               1401


<210> 3869
<211> 4569
<212> DNA
<213> Homo sapiens

<400> 3869
ggccggggca ggggcctctg gctcccgaca ctggccgaga ggtgggttcc ggggcgggtc       60

gctgctcctt gaagccgggc ggggacgcgc tgcccccgcc ctgcctccct gtggtccaca      120

ccccctttgg gctccggagc cgctgggcag gaatagtccg gggtgcgcgc gagcaggcgc      180

tgccaacccc acttctgccc gggattccaa tctgaggagc aggaggaccg gggcgccggt      240

gtcctgccgc ctccttctcc ttgctctcac ctgcgcctat tagtccacgc gccttcaagg      300

ccaggggcta cagcccagac agagagggga cagcagaggg agagagagca cctgaggata      360

cagagctggc actggactgc cttttcaccc cccaggtgat gagtgaggtt cgaagaacgg      420

aagatttaaa aagcagccgg ggcctccgta ttgaatgaaa gacccagtgc aaagacatca      480

ccatgaacac tagcattcct tatcagcaga atccttacaa tccacggggc agctccaatg      540

tcatccagtg ctaccgctgt ggagacacct gcaaagggga agtggtccgc gtgcacaaca      600

accacttcca catcagatgc ttcacctgtc aagtatgtgg ctgtggcctg gcccagtcag      660

gcttcttctt caagaaccag gagtacatct gcacccagga ctaccagcaa ctctatggca      720

cccgctgtga cagctgccgg gacttcatca caggcgaagt catctcggcc ctgggccgca      780

cttaccaccc caagtgcttc gtgtgcagct tgtgcaggaa gcctttcccc attggagaca      840

aggtgacctt cagcggtaaa gaatgtgtgt gccaaacgtg ctcccagtcc atggccagca      900

gtaagcccat caagattcgt ggaccaagcc actgtgccgg gtgcaaggag gagatcaagc      960

acggccagtc actcctggct ctggacaagc agtggcacgt cagctgcttc aagtgccaga     1020

cctgcagcgt catcctcacc ggggagtata tcagcaagga tggtgttcca tactgtgagt     1080

ccgactacca tgcccagttt ggcattaaat gtgagacttg tgaccgatac atcagtggca     1140

gagtcttgga ggcaggaggg aagcactacc acccaacctg tgccaggtgt gtacgctgcc     1200

accagatgtt caccgaagga gaggaaatgt acctcacagg ttccgaggtt tggcacccca     1260

tctgcaaaca ggcagcccgg gcagagaaga agttaaagca tagacggaca tctgaaacct     1320

ccatctcacc ccctggatcc agcattgggt cacccaaccg agtcatctgc gctaaagtgg     1380

ataatgagat ccttaattac aaagacctgg cggctctccc caaggttaag tctatctacg     1440

aggtacaacg ccccgacctc atttcctatg agcctcattc cagatacatg tccgacgaga     1500

tgctggagag atgtggctat ggagagtcgc tgggaacatt atctccctac tcccaggaca     1560

tctacgagaa cctggacctc cggcagagac gggcctccag cccggggtac atagactccc     1620

ccacctacag ccggcagggc atgtccccca ccttctcccg ctcacctcac cactactacc     1680

gctctgggcc cgagagtggc cggagctctc cataccatag ccagttagat gtgaggtcct     1740

ccactccaac ctcttaccag gctcccaagc actttcacat cccagctgga gacagtaaca     1800

tctaccggaa acccccgatc tacaaacggc atggtgattt gtctacagca accaagagca     1860

aaacaagtga agacatcagc cagacctcca agtacagtcc catctactcg ccagacccct     1920

actatgcttc ggagtctgag tactggacct accatgggtc ccccaaagtg ccccgagcca     1980

gaaggttctc gtctggagga gaggaggatg attttgaccg cagcatgcac aagctccaaa     2040

gtggaattgg ccggctgatt ctgaaggaag aaatgaaggc ccggtcgagc tcctatgcag     2100

atccctggac ccctccccgg agctccacca gcagccggga agccctgcac acagctggct     2160

atgagatgtc cctcaatggc tcccctcggt cgcactacct ggctgacagt gatcctctca     2220

tctccaaatc tgcctccctg cctgcctacc gaagaaatgg gctgcacagg acacccagcg     2280

cagacctctt ccactacgac agcatgaacg cagtcaactg gggcatgcga gagtacaaga     2340

tctaccctta tgaactgctg ctggtgacta caagaggaag aaaccgactg cccaaggatg     2400

tagacaggac ccgtttagag cgccacctgt cccaggaaga gttctaccaa gtctttggca     2460

tgaccatctc tgagtttgac cggctggccc tctggaagag gaatgaactg aagaagcaag     2520

cccggctgtt ctaggcagag gctctataaa tatatatgca tttatataaa gatatatgta     2580

aaatctctct actgaagctc ggtataatcc tctcttgtgt aatgggacac actgcctgcc     2640

atgagacttg cttttctgta ctgtcaggca agcccacgtc atcgagatat ttttatgctc     2700

cttactttct cttttctaag tgctgtggga tctgggaagg gatttgaggg gactctgtcc     2760

ttttattggg gatccttttt atactgaaac atctgtccta acttgagtgc cccaaggtcc     2820

aactctcttt cctaaagaag gtgcctgaag aagtctctct tctctctgct tcgtggcccc     2880

tttcttaaat ttctagggct gatgctgacc atgtggtttc cacaccttat tggccccaga     2940

ggggccctcc catgggaaga tctgcagcag tctccccaaa tcagtgagca cctttgagcg     3000

cccacgaaga actttctcaa cacccccaat taggagctca gtgctctctt ggggcaatgc     3060

agttaaaagg gtgagcctca aatctagtca ttacaccagt caacagaagt ggacagggcc     3120

taggcctctc ctcagctcct taaccctcct ccttctgccc tggattgtaa cctctccctt     3180

gtccaaatct aggattcctg gtaggaaaag gaaaaggccc ttcccttccc tccaccactt     3240

ccaactggcc cctttgcctg acctggactt ggagaaccag aggaaaagag agggagcgga     3300

agtgggagat ggagcagggc acctgttaga atcagagctg caggatttct tgggaccctc     3360

ctctctccct cactgctccc agcacctcct gacccttccc tctttcaagg agaagcccat     3420

gattgcagct tgtattcttt agccttatta caatctatgt gcctgacaac tcaacacacc     3480

gcagggctaa tgttcccacc agagctccaa ctgaacaacc agacagacaa ctctcatcat     3540

cctccagaga gaaaataggc cgtgtctcaa agaaaggttc ttggtctatg cctctggtct     3600

gtgggctggc agggcaacca taccataccc ccgccagtcc tcggctcctg ctgcaaagtt     3660

ggccatgttt cacagggaaa cttttggaag agtggctgct tatgagattc caaaatgaag     3720

tgttggccaa caccgctcat ggccatcctg gattttccca gtggcttccc ttcctgctcg     3780

cctccctgaa caggggagaa agcttaacct ctcttctcct ctccaaacct ttcaccttga     3840

atgggtaatg tttggtgggg gctgttcctt cttggagaag ccttgagtcg gaccattttg     3900

agatcatgga ggaaggatga agaagtgaaa atgacaataa tgactctcaa gaggctggcg     3960

atgtgacatg gcaaatgtag aactgactta aattgaacaa accctcactg agcacctctg     4020

atgttgagca cctgctgaat actgagcact gaatggggga gggggagggg agcacggggt     4080

gagtcaacct gggactcggt ctcagggata tgcctaccaa tagcgggtat cgtaaggcat     4140

gtacccaaac ataacggatg taaggcagaa agtgatcgga gaaggaatga gaaagtgtgc     4200

gtgatgttaa tgaaaagtca tatgcagcta gagcagaccc aggaaagctt tctggaagag     4260

attgcatctg aggaaattca ggaaggatct ttgtagattg gggggagatt ctaaattgaa     4320

ggggtgatgg ggtgaggggc cagagggaag tctgctgtgt tctcatgtag gatgtcagcc     4380

ctccctgcaa cttctctttt tggccaatgt cttttcactt tcctgaccct ttagaatcat     4440

ccccagccag acgcaatcat ggaagttgcc ttattgtcac tggttaagaa cttggcgaga     4500

ttgaagggct tttgttattg ttgttggata tttttgtttc ccataaaagc acatcatttc     4560

aaccctaaa                                                             4569


<210> 3870
<211> 443
<212> DNA
<213> Homo sapiens

<400> 3870
tgtcaggttg ccgtctaggt agcggttgtg cttgctgagg ctgcacttgc tgacactgca       60

gctgcgacgc ggctaagagg cgcagagcga ggagtcggga tttggtcgcg agcggcgacg      120

agcatttgtg cagaatgtca tcagatgagg agaaatactc acttccagtt gtgcaaaatg      180

actccagtcg aggcagttct gtctcttcga atcttcagga aataactctg aagtaagaga      240

aactgcaata gaagttggaa aaggatgtga tttccatatt tcaagtcatt caaagacaga      300

tgagtcatca ccagtgttat cgccaaggaa gccttctcac ccagtcatgg attttttcag      360

ttcacatctt ttagctgact cttcctcacc agcaacaaat tctagtcata cagatgccca      420

tgaaatactt gtgagcgatt ttc                                              443


<210> 3871
<211> 1674
<212> DNA
<213> Homo sapiens

<400> 3871
gcgggacgga gcttggctgt tggtcggtgg gttcccgtgc ggcggcggcc aaggaggagg       60

agacacagtt ggagcagctc cgtgggctga ctggggcgag gcctcagcag cgcgagcttg      120

agtgcggccg agcctgcggc gccttcccct gcgggtgggg acgagcgggc cccgcggcgt      180

catcggcggc gaggtgagcg gcggccggcg ggcgggagct ctggcgggag ccgcgccggc      240

ctgacgcgct gtcgccgctg gttgcaggag ccgccgcgcc tcggcctagc atgtcggaag      300

cgggcgagga gcagcccatg gagacgacgg gcgccaccga gaacggacat gaggccgtcc      360

ccgaaggcga gtcgccggcc ggggctggca cgggcgccgc ggcgggggct ggaggcgcga      420

ccgcggcgcc cccgagcggg aatcagaacg gcgccgaggg cgaccagatc aacgccagca      480

agaacgagga ggacgcggga aaaatgttcg ttggtggcct gagctgggat actagcaaaa      540

aagatttaaa agactatttt actaaatttg gagaggtcgt tgactgtaca ataaaaatgg      600

atcccaacac tggacggtca agagggtttg ggtttatcct gttcaaagat gcagccagtg      660

tggagaaggt cctagaccag aaggagcaca ggctggatgg ccgtgtcatt gaccctaaaa      720

aggccatggc tatgaagaag gacccggtga agaaaatctt cgttgggggt ctgaatcctg      780

aagccactga ggaaaagatc agggagtact ttggcgagtt tggggagatt gaggccattg      840

aattgccaat ggatccaaag ttgaacaaaa gacgaggttt tgtgtttatc acctttaaag      900

aagaagaacc cgtgaagaag gttctggaga aaaagttcca tactgtcagt ggaagcaagt      960

gtgagatcaa ggtggcccag cccaaagaag tctatcagca gcagcagtat ggctctgggg     1020

gccgtggaaa ccgcaaccga gggaaccgag gcagcggagg tggtggtgga ggtggaggtc     1080

agggtagtac aaactacggc aagagccagc gacgtggtgg ccatcagaat aactacaagc     1140

catactgagg cggcagcagg agcgaccaac tgatcgcaca catgctttgt ttggatatgg     1200

agtgaacaca attatgtacc aaatttaact tggcaaactt tctattgcct gtcccatgtg     1260

catcttattt aaaatttccc ccatggaaat cactctcctg ttgactattt ccagagctct     1320

aggtgtttag gcagcgtgtg gtgtctgaga ggccatagcg ccatcatggg ctgattttta     1380

ttaccaggtc ccccagaagc aggtgggagg ctctgcttcc tgctgccgct ctgcagcctg     1440

gacctgtgga ccctggttgt aaagagtaaa ttgtatctta ggaaaccagt gtcacctttt     1500

tttcaccttt taattttata ttatttgcgt catacatttc ctgtaacgga agtgttaatt     1560

ttactgtact ttttggtacc ttttgggaat ctaatgtatt gtaaggtatt ttacacgtgt     1620

cctgattttg ccacaacctg gatattgaag ctatccaagc ttttgaaata aaat           1674


<210> 3872
<211> 549
<212> DNA
<213> Homo sapiens

<400> 3872
tttccttacc aatcggctgc catccgagga gctgaggaag cctagagctc tcagaagcag       60

tcctttgagc tggtgtaggg cggtgtttct ccaactgggc tcgtggcact tttctggaca      120

ccactccaaa caaaattaga ctctgagcac tcagaatggt ccagcgtttg acataccgac      180

gtaggctttc ctacaataca gcctctaaca aaactaggct gtcccgaacc cctggtaata      240

gaattgttta cctttatacc aagaaggttg ggaaagcacc aaaatctgca tgtggtgtgt      300

gcccaggcag acttcgaggg gttcgtgctg taagacctaa agttcttatg agattgtcca      360

aaacaaagaa acatgtcagc agggcctatg gtggttccat gtgtgctaaa tgtgttcgtg      420

acaggatcaa gcgtgctttc cttatcgagg agcagaaaat cgttgtgaaa gtgttgaagg      480

cacaagcaca gagtcagaaa gctaaataaa aaaatgaaac ttttttgagt aataaaaatg      540

aaaagacgc                                                              549


<210> 3873
<211> 7960
<212> DNA
<213> Homo sapiens

<400> 3873
agtgccctgg gacacctctt cagtccgtgg actttcccgc tgcacactgc cctccgaagt       60

cggggacgcg ggctcgtgag atggaagatt ttcgaggtat agcagaagaa tcatttccaa      120

gctttctcac caattcatta tttggtaaca gtgggatttt ggaaaatgtc actctttctt      180

caaatcttgg cttgcctgtt gctgtttcta cacttgctag ggatagatcc agcactgata      240

acaggtatcc tgatatccag gcatcttact tagtagaagg gagattttca gttccatccg      300

ggtcatctcc cggaagccag agtgatgctg aaccaagaga gaggttacag cttagcttcc      360

aggatgatga ttctatctct aggaaaaaga gctatgtgga aagtcaacgt ttgtcaaatg      420

ctctcagcaa acagtcagct ttacaaatgg agacagcagg accagaagag gagccagccg      480

gagctacaga atccttgcag ggccaagatc tcttcaacag ggcttcacca ctggaacaag      540

cacaagactc acctattgat tttcatttac agtcatggat gaataataag gaacccaaga      600

ttgttgtgct tgatgctgga aaacattttg aagacaagac tctaaagagt gacctaagcc      660

acactagctt attagaaaat gagaaactta tcttaccgac aagcttggaa gattcttctg      720

atgatgatat tgatgatgaa atgttttatg atgatcattt ggaggcttat tttgaacaac      780

tggcaattcc aggaatgata tatgaagacc tagaaggacc agaacctcca gaaaaaggtt      840

ttaagttacc tacaaatggt cttagacagg caaatgaaaa cggtagctta aactgcaagt      900

ttcaatcaga aaataacagc tctctgattt ccctcgactc acactcttct gaaacaactc      960

acaaagagtc tgaggaaagc caagttattt gtctacctgg gactagtaat tctataggta     1020

ctggagatag tagaaggtac acagatggta tgttaccatt ttcctctggt acttggggaa     1080

ctgagaaaga aatagaaaat ttgaagggta ttgttccaga tcttaacagt gaatgtgcaa     1140

gtaaagatgt tctggtgaag accctcaggg ctattgatgt gaaacttaac tctgataatt     1200

ttcatgatgc aaatgccaat agaggtggtt ttgatctgac tgaccctgta aaacaggggg     1260

cagagtgtcc tcaccaaaat aagacagttt tgcacatgga tggatgttta gacactgaga     1320

ctcctacggt gtccattcaa gaaaatgtgg atgtagcctc tttgaagccc attagtgaca     1380

gtggaattaa tttcactgat gccatttggt caccaacttg tgaaaggcga acatgtgaat     1440

gtcacgagtc catcgaaaag aataaagaca aaacagatct cccacagagt gtggtctatc     1500

aaaatgaaga gggtaggtgg gtcacagacc ttgcctatta cacatctttt aatagcaaac     1560

aaaatttaaa tgtgtctcta agtgatgaga tgaatgaaga cttcagatct ggttctgaag     1620

catttgattt gattgcacaa gatgaagaag aatttaataa agagcatcaa tttatacagg     1680

aagaaaacat agatgctcat aatacttcgg ttgcactggg cgatacgtcc tggggagcta     1740

caattaatta cagtctgttg aggaaatcac gtagcacatc agatttggat aaagatgatg     1800

ccagttattt acgtctgtct ttaggagagt tctttgctca aagatctgaa gctcttggtt     1860

gccttggtgg tggtaacaat gtgaaaagac catcatttgg ctattttatt agatcaccag     1920

agaagagaga acctattgcc ttaataagaa aatctgatgt atcaagaggt aatttggaaa     1980

aagaaatggc tcatcttaac catgatctat attcaggaga tttaaatgaa cagtcccagg     2040

cacagctaag tgaaggatca attacacttc aggttgaagc agtagagagt acttcacaag     2100

tggatgaaaa tgatgtgacg ttaacggctg ataaaggcaa aacagaggac actttcttca     2160

tgagcaacaa accccaaaga tacaaagaca agctaccaga tagtggtgat tctatgctta     2220

ggatcagcac cattgcttca gccattgcag aggcatcagt taatactgat ccttcccaac     2280

ttgctgcaat gatcaaggca ctttcaaata aaaccagaga caagactttt caggaagatg     2340

agaaacaaaa ggactattct catgtgcgtc atttcttacc taatgattta gaaaaaagta     2400

atggatccaa tgcacttgat atggagaaat accttaaaaa aacagaagtt agtagatatg     2460

aaagtgcatt ggaaaacttt tcaagggcta gtatgtctga tacttgggat ttatctttgc     2520

ccaaagaaca aactactcaa gacattcatc cggtggactt aagtgctact agtgtaagtg     2580

tgagggcacc agaagaaaac acagcagcta ttgtttatgt tgaaaatgga gagagtgaga     2640

atcaagagtc atttagaacc ataaactcct caaattcagt tacaaataga gagaataaca     2700

gtgcagtagt tgatgtgaag acatgttcca ttgacaacaa attacaagat gttggtaacg     2760

atgaaaaagc tacctcaatt tccactccat ctgatagtta ttcatcagtg aggaacccca     2820

gaataacatc cctttgtctg ttaaaagact gtgaagaaat acgagataac agagaaaatc     2880

agaggcaaaa tgagtgtgtc agtgaaataa gcaacagtga gaagcatgtg acttttgaaa     2940

accatcgcat agtctcacct aaaaatagtg atttgaaaaa tacctctcct gagcatggtg     3000

gacgtggctc agaggatgag caggagagct tcagaccttc cacgtcacca ctgagtcatt     3060

cttctcctag tgaaatttct ggaacgagtt catcagggtg tgcgttagag tcctttggtt     3120

cagcagctca gcagcagcag cctccctgtg agcaggagtt gtctcccttg gtgtgctcgc     3180

ctgctggggt gagcaggctg acgtatgtgt ctgaaccaga gagctcctat cctaccacag     3240

ccacagatga tgccctggag gaccgcaaga gtgatatcac cagcgagttg agtaccacaa     3300

ttattcaagg cagtccagcc gcattggagg aacgggctat ggaaaaattg agagaaaaag     3360

ttccatttca gaatagagga aaaggaacat tatcatctat tatccagaat aactctgata     3420

caagaaaagc aactgaaact acttctctga gtagcaagcc tgaatatgta aaacctgact     3480

ttagatggag taaagatcct tcctccaaaa gtggaaatct gttggaaacc agtgaggtag     3540

gttggacatc aaaccctgag gaattggacc cgatcaggct ggctctcctg ggcaagtcag     3600

gtctgagctg tcaggtgggg tcagccacat cacaccctgt gtcctgccag gagcctatag     3660

atgaagatca aagaataagt cctaaagata agtcaactgc tggccgtgag ttcagtggcc     3720

aggtttctca tcagaccacc tctgaaaacc agtgtactcc tattcccagc agcacagttc     3780

acagctctgt ggctgacatg cagaacatgc ctgctgctgt gcacgcactc ttgacacaac     3840

cctctctcag cgctgctcct tttgctcagc ggtatttggg aacactccct tcaactggaa     3900

gcaccacctt gcctcagtgc catgctggca atgccacagt ctgtggcttc tcaggaggcc     3960

ttccctatcc agctgttgca ggagagcctg tgcagaactc tgtggctgtg ggaatttgtc     4020

taggatcaaa tatcggctct ggatggatgg gtacctcttc cctctgtaac ccatattcta     4080

ataccttaaa tcagaacctg ctaagcacaa caaaaccttt tcctgtgccg tctgttggta     4140

caaactgtgg aattgaacca tgggattcag gagtgacatc aggattgggg agtgtccgag     4200

tgcccgagga gttgaagctt cctcatgctt gctgtgtcgg gatcgcttcc cagaccctcc     4260

tcagtgtgct taatccaact gaccgctggc tgcaagtcag cattggggtc ctcagcatta     4320

gtgttaatgg tgaaaaggtg gatctttcaa catatcgttg tttagttttc aagaataaag     4380

ccatcataag acctcatgcc acagaagaga taaaagtgct ttttatacca tccagtcctg     4440

gggttttcag atgcacattc agtgttgctt cttggccatg ttcgacagat gctgagacca     4500

tcgtacaggc agaagctttg gccagcaccg tcactctcac tgccattgcc gagagtcctg     4560

ttattgaggt agaaacagaa aagaaagacg ttcttgattt tggtgacttg acttatggag     4620

gctggaaagc cctcccacta aaattgataa accgaacgca tgccactgtg ccaattagac     4680

tgattattaa tgctaacgct gtagcctggc gctgtttcac gttttccaag gaatccgtcc     4740

gagctcctgt ggaagttgct ccttgcgctg atgtggtcac tcggctagca ggcccttctg     4800

tggtcaacca catgatgcct gctagttatg atggacagga tccagaattt ctgatgattt     4860

gggttctttt ccatagtcca aagaaacaga tcagctcttc agatattctg gactcagcag     4920

aagaattctc ggcaaaagtt gatatcgaag ttgacagccc aaaccctacg cccgttctta     4980

gaagtgtgag tctccgagca agagcaggaa tagctaggat ccatgctccc agggacttgc     5040

agacgatgca tttcttggcc aaagtggctt cctcaagaaa gcagcactta cctttgaaaa     5100

atgctgggaa cattgaagtt tatttggata tcaaggtccc agaacaagga agtcactttt     5160

cagtggatcc aaagaatcta ctccttaaac ctggagaaga acatgaggtt attgtttcat     5220

ttactccaaa ggatcctgaa gcctgcgagg aaaggatctt gaaaatattt gtgcagccat     5280

ttggacctca gtatgaggta gtgttaaaag gcgaagtcat ttcttcagga agtaaacctc     5340

tgtcacctgg accttgctta gatattccat cgattttgtc caacaaacaa tttctggctt     5400

ggggaggagt ccctctaggt agaacacagc ttcagaaact agctttaaga aataattctg     5460

catctacaac tcaacattta cgactgctta ttagaggaca agatcaggac tgctttcagc     5520

ttcagaacac ttttggttca gaacagcgat tgaccagtaa ctgtgagatc agaattcacc     5580

caaaggaaga cattttcatc tctgtattat ttgcacctac tcgattatct tgcatgttgg     5640

ctagactaga aatcaaacaa cttggaaatc gatcacaacc aggcattaag ttcacaatac     5700

ctttgtctgg atatggagga acaagcaatc ttattttgga aggcgttaaa aaattatctg     5760

acagttacat ggtaacagtg aatggcttag tacctggcaa agaaagtaaa attgtttttt     5820

ctgtccgcaa cactggctcc cgagcagctt ttgttaaagc agtaggtttt aaggattctc     5880

agaaaaaagt tttgctggat cctaaagtat tgaggatttt tccagataaa tttgtactca     5940

aggaaagaac acaagaaaat gttactttaa tatataatcc atcagacaga ggaatcaata     6000

ataaaactgc aacagaacta tcaactgtat acttatttgg tggagatgaa atttcaagac     6060

agcagtatcg cagggccctg ttacataaac cagagatgat aaaacagata cttccagaac     6120

atagtgtgct tcaaaacatt aattttgttg aagcatttca agatgagcta ttagtaactg     6180

aagtatatga tcttccccaa cgacctaatg atgttcagct cttttatgga agcatgtgta     6240

aaattatact ttcagtaatt ggagaattca gagattgcat ttctagcaga gaattccttc     6300

agccttcttc caaagctagc ttggaatcta caagcgactt gggagcttct gggaaacatg     6360

gtggcaacgt ctctttggat gttttaccag tcaaaggtcc tcagggttct cctcttctct     6420

cacgggcggc tcgcccgcct ctggatcagc tggcctccga agagccgtgg actgtcctac     6480

ccgagcactt gattctggta gctccttctc cttgtgacat ggcaaaaact ggacgtttcc     6540

agattgtgaa taactctgtg aggttactga gatttgagct gtgctggcca gcgcattgcc     6600

tcacagtcac gccgcagcat ggatgtgtcg cgccagagag taaactacaa attcttgtga     6660

gtcctaattc ctccttatcc acaaaacagt caatgttccc gtggagtggt ttgatctata     6720

tacactgtga cgatggacag aagaaaattg tgaaagttca aattcgagaa gatttaactc     6780

aagtggaact tttaactcgt ttgacctcca aaccatttgg aattctttcc ccagtatctg     6840

agccttcagt tagtcatttg gtcaaaccaa tgacaaaacc gccttccaca aaagttgaaa     6900

taagaaacaa gagtattact tttcctacaa cagaacctgg tgaaacttca gagagctgtc     6960

tagaactcga gaatcatggc accacagacg tgaaatggca tctgtcatct ttagcgccac     7020

cttatgtcaa gggagttgat gaaagtggag atgtttttag agctacctat gcagcattca     7080

gatgttctcc tatttctggt ctgctggaaa gccatgggat ccaaaaagtc tccatcacat     7140

ttttgcccag aggtaggggg gattatgccc agttttggga tgttgaatgt caccctctta     7200

aggagcctca catgaaacac acgttgagat tccaactctc tggacaaagc atcgaagcag     7260

aaaatgagcc tgaaaacgca tgcctttcca cggattccct cattaaaata gatcatttag     7320

ttaagccccg aagacaagct gtgtcagagg cttctgctcg catacctgag cagcttgatg     7380

tgactgctcg tggagtttat gccccagagg atgtgtacag gttccggccg actagtgtgg     7440

gggaatcacg gacacttaaa gtcaatctgc gaaataattc ttttattaca cactcactga     7500

agtttttgag tcccagagag ccattctatg tcaaacattc caagtactct ttgagagccc     7560

agcattacat caacatgccc gtgcagttca aaccgaagtc cgcaggcaaa tttgaagctt     7620

tgcttgtcat tcaaacagat gaaggcaaga gtattgctat tcgactaatt ggtgaagctc     7680

ttggaaaaaa ttaactagaa tacatttttg tgtaaagtaa attacataag ttgtattttg     7740

ttaactttat ctttctacac tacaattatg cttttgtata tatattttgt atgatggata     7800

tctataattg tagattttgt ttttacaagc taatactgaa gactcgactg aaatattatg     7860

tatctagccc atagtattgt acttaacttt tacaggtgag aagagagttc tgtgtttgca     7920

ttgattatga tattctgaat aaatatggaa tatattttaa                           7960


<210> 3874
<211> 540
<212> DNA
<213> Homo sapiens

<400> 3874
agtgtgctgg aaagttctac agatttcgcc atcagactat ccattcctat tcttgaaaaa       60

tctgcagtgc tggagttatt tgcaattccc ccccgccaat ctttaaataa ttgtctcaga      120

gatatagata gatatagatt gcccacgggt gattttttta atcccggtta ccacttgtaa      180

taaaagaggt tgaattttgg agagaattga tatttaaatt gcatgttttt ttttctgtat      240

tataattatg cacattgatt tagttttaaa attagtgagg ttggaatgtt agtattttga      300

tttgaaatct gggatctttg gaggtgattt aagattatgg tttgataaga actccatttt      360

ctgttgatgt ggagacatag ggtacctcca actttccggg gtttcagaag agaatttttt      420

attgaaactg gaagaccaaa ataattacaa gcatgttgtg ctggggaaat gcatcctttg      480

ggcagctagg tttgggtgga attgatgaag aaattgtact agagcccaga aaaagtgact      540


<210> 3875
<211> 688
<212> DNA
<213> Homo sapiens

<400> 3875
atcagaaagc tccgcagttc ttgagttcca catgcagagc agatgcgaca gctagaagtg       60

agtagggccc agaccctggc ccaggaagat ccactaaagg aggccatcct tccgccttct      120

tctgcaggag tcagggggcg tgtaaaggtg atttgttcgc caagaaaagc acttttagta      180

aagcacagat gttaatctag atcatggaaa agtgccacac actagattta gcacataagc      240

aaggagtctc tagaacactc agaagaaaat gaatgaatcc atgaatgaat ggacaagtga      300

gagcccagag cagctgaagc catgaagtgc tttggaaaga gaagcgtgcc tgggaaaaga      360

gagtggctga gtgctaagag cagggtgaac accatggaaa acttgaaatt gaaaacatca      420

caattttaat gagaaaaagc gcaacccaaa gtgaagagca ccattataac aaaggatgga      480

aaggcagatg taaagtccct catggcgaaa tataacacgg ggggcaaccc gacagaggat      540

gtctcagtca atagccgacc cttcagagtc acagggccaa actcatcttc aggaatacaa      600

gcaagaaaga acttattcaa caaccaagga aatgccagcc ctcctgcagg acccagcaat      660

gtacctaagt ttgggtcccc aaagccac                                         688


<210> 3876
<211> 711
<212> DNA
<213> Homo sapiens

<400> 3876
atgcgcagta gctgtaggag ggggtgggcg ctccattggg cgtttctctt ggtttttcct       60

ttccgcgcgg cttgggcgga cgtctcgtga gacgtgggac ttctcgcggg aactgcattc      120

aaatatccca ggcgcttact cgagagctag ctgagcgaat gggccggcga ctgtggagtt      180

agcgtcctca atgtggacgc cctgagctcc cattaggagc cgctggctgc ggcagcaggg      240

gactagcgtg agagtttcat gagggaggag cttttttttc gtccattttg ttccctaatg      300

aatctgaact gcccagaatg gaacctagta tataaggcat tcaagaaata ctcgttcagt      360

gaatgactac attgacttga gacatggggg aacatcttgc aatgacctgg tgccctttga      420

aggcaaagtt ggctaaaaaa aagaaaagaa catggaggca gatataatca caaatcttcg      480

atgcaggctc aaagaggctg aagaagagcg actaaaagct gcacagtatg gtttacaact      540

agtagagagt caaaatgaat tacagaatca attggataaa tgtcgtaatg aaatgatgac      600

catgactgag agttatgaac aagaaaaata tacccttcaa agagaagttg aactcaagag      660

tcgaatgtta gaaagtttga gctgcgaatg tgaagctatt aaacaacaac a               711


<210> 3877
<211> 2219
<212> DNA
<213> Homo sapiens

<400> 3877
agggcttaat agttttccaa gtgcttcaag acatgttagc taattggatc ttcacaggaa       60

ctctatgagg ccgaatacat caagcaatgg taacatcttt aaatgaagat aatgaaagtg      120

taactgttga atggatagaa aatggagata caaaaggcaa agagattgac ctggagagca      180

tcttttcact taaccctgac cttgttcctg atgaagaaat tgaacccagt ccagaaacac      240

ctccacctcc agcatcctca gccaaagtaa acaaaattgt aaagaatcga cggactgtag      300

cttctattaa gaatgaccct ccttcaagag ataatagagt ggttggttca gcacgtgcac      360

ggcccagtca atttcctgaa cagtcttcct ctgcacaaca gaatgcacgt agaaaatcta      420

attgtgtgaa agaagtagaa aaactgcaag aaaaacgaga gaaaaggaga ttgcaacagc      480

aagaacttag agaaaaaaga gcccaggacg ttgatgctac aaacccaaat tatgaaatta      540

tgtgtatgat cagagacttt agaggaagtt tggattatag accattaaca acagcagatc      600

ctattgatga acataggata tgtgtgtgtg taagaaaacg accactcaat aaaaaagaaa      660

ctcaaatgaa agatcttgat gtaatcacaa ttcctagtaa agatgttgtg atggtacatg      720

aaccaaaaca aaaagtagat ttaacaaggt acctagaaaa ccaaacattt cgttttgatt      780

atgcctttga tgactcagct cctaatgaaa tggtttacag gtttactgct agaccactag      840

tggaaactat atttgaaagg ggaatggcta catgctttgc ttatgggcag actggaagtg      900

gaaaaactca tactatgggt ggtgactttt caggaaagaa ccaagattgt tctaaaggaa      960

tttatgcatt agcagctcga gatgtctttt taatgctaaa gaagccaaac tataagaagc     1020

tagaacttca agtatatgca accttctttg aaatttatag tggaaaggtg tttgacttgc     1080

taaacaggaa aacaaaatta agagttctag aagatggaaa acagcaggtt caagtggtgg     1140

gattacagga acgggaggtc aaatgtgttg aagatgtact gaaactcatt gacataggca     1200

acagttgcag aacatccggt caaacatctg caaatgcaca ttcatctcgg agccatgcag     1260

tgtttcagat tattcttaga aggaaaggaa aactacatgg caaattttct ctcattgatt     1320

tggctggaaa tgaaagagga gctgatactt ccagtgcgga caggcaaact aggcttgaag     1380

gtgctgaaat taataaaagc cttttagcac tcaaggagtg catcagagcc ttaggtagaa     1440

ataaacctca tactcctttc cgtgcaagta aactcactca ggtgttaaga gattctttca     1500

taggtgaaaa ctctcgtacc tgcatgattg ccacaatctc tccaggaatg gcatcctgtg     1560

aaaatactct taatacatta agatatgcaa atagggtcaa agaattgact gtagatccaa     1620

ctgctgctgg tgatgttcgt ccaataatgc accatccacc aaaccagatt gatgacttag     1680

agacacagtg gggtgtgggg agttcccctc agagagatga tctaaaactt ctttgtgaac     1740

aaaatgaaga agaagtctct ccacagttgt ttactttcca cgaagctgtt tcacaaatgg     1800

tagaaatgga agaacaagtt gtagaagatc acagggcagt gttccaggaa tctattcggt     1860

ggttagaaga tgaaaaggcc ctcttagaga tgactgaaga agtagattat gatgtcgatt     1920

catatgctac acaacttgaa gctattcttg agcaaaaaat agacatttta actgaactgc     1980

gggataaagt gaaatctttc cgtgcagctc tacaagagga ggaacaagcc agcaagcaaa     2040

tcaacccgaa gagaccccgt gccctttaaa ccggcatttg ctgctaaagg atacccagaa     2100

ccctcactac tgtaacatac aacggttcag ctgtaagggc catttgaaag tttggaattt     2160

taagtgtctg tggaaaatgt tttgtccttc acctgaatta catttcaatt ttgtgaaac      2219


<210> 3878
<211> 457
<212> DNA
<213> Homo sapiens

<400> 3878
aggtggcata ttggtttttc tggaatccgt tgcgaaactg ttcttatcta cttaaaggga       60

actcatttga agtctgagtc ttgagggaat aggcagaaca ggcatgttgg aaggaaagta      120

tgagtctcag gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc      180

ctgactcaca ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg      240

ggatgggaac aacatgtctt cacctaggga ctttagagca gagcctgtaa acgattatga      300

gggaaatgac tctgaagcag aagacttgaa tttcagggag actttgcctt catcaagtca      360

ggaaaacaca cctagatcaa aggtttttga aaataaagtt aattcagaga aggtaaaact      420

ttctcttcgg aatttcccac ataatgatta tgaggat                               457


<210> 3879
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3879
agtgcctccg ggtcgcggtc attttgagcc cctgtctgga tgacttcttg cggctgttct       60

acccctcccc ctccccgcgt cgcctgctgc tgtcgtcggg aggtgggtga ggtgacgcaa      120

acagccccgt tgttgccctc cgcgtatccc ctcaccacct ttgcggccat ccacgacttt      180

cgcaccttcc gccattttcc tgcctgtgag ggtggacaga tcgcgctcgg gtctcggcct      240

cctgagtgcc ggtgactgcg ggaggcgacg gagtgcttct gggggtgaaa gatgaatggg      300

agggctgatt ttcgagagcc gaatgcagag gttccaagac caattcccca catagggcct      360

gattacattc caacagagga agaaaggaga gtcttcgcag aatgcaatga tgaaagcttc      420

tggttcagat ctgtgccttt ggctgcaaca agtatgttga ttactcaagg attaattagt      480

aaaggaatac tttcaagtca tcccaaatat ggttccatcc ctaaacttat acttgcttgt      540

atcatgggat actttgctgg aaaactttct tatgtgaaaa ct                         582


<210> 3880
<211> 567
<212> DNA
<213> Homo sapiens

<400> 3880
gacgcagatg cgaaagtggc ggcctccggg caccatttct gtgcacggaa acagaatccg       60

ggtttgaagg cagccgccgc ttcgcttacc cagttaggcc gggcacggtg gctcacgcct      120

gtaatcccag cactttggga ggccgaggcg ggcggatcat ctgaggtcag gagttcgagg      180

ccagcctgac caacatggag aaaccccgtc tctactaaaa atacataatt agccagcatt      240

tgacattgtg cagcaaagaa atggttatgg agaagcccag tccgctgctt gtagggcggg      300

agtttgtgag gcaatattat actttgctga ataaagctcc ggaatattta cacaggtttt      360

atggcaggaa ttcttcctat gttcatggtg gagtagatgc tagtggaaag ccccaggaag      420

ctgtttatgg ccaaaatgat atacaccaca aagtattatc tctgaacttc agtgaatgtc      480

atactaaaat tcgtcatgtg gatgctcatg caaccttgag tgatggagta gttgtccagg      540

tcatgggttt gctgtctaac agtggac                                          567


<210> 3881
<211> 742
<212> DNA
<213> Homo sapiens

<400> 3881
tggcctgact cacaggacac taaggctcct tttctgaaga agccttttac cagtctcatt       60

taggggatgg gaacaacatg tcttcaccta gggactttag agcagagcct ggtttttgaa      120

aataaagtta attcagagaa ggtaaaactt tctcttcgga atttcccaca taatgattat      180

gaggatgttt ttgaagagcc ttcagaaagt ggcagtgatc ccagcatgtg gacagccaga      240

ggccccttca gaagagacag gtggagcagt gaggatgagg aggctgcagg gccatcacag      300

gctctctccc ctctactttc tgatacgcgc aaaattgttt ctgaaggaga actagatcag      360

ttggctcaga ttcggccatt aatattcaat tttcatgagc agacagccat caaggattgt      420

ttgaaaatcc ttgaggaaaa aacagcagcg tatgatatca tgcaggaatt tatggcttta      480

gaacttaaga atctgcctgg tgagttcaac tctgggaatc aaccaagcaa cagagaaaaa      540

aatagatacc gagatattct tccatttcaa catcatggat atagtggccc aaatgagaga      600

acaacgttct ggcatggttc aaacgaagga gcagtatcac ttttgttacg atattgtgct      660

tgaagttctt cggaaacttc tgactttgga ttaagaaaga cttctgttgc ctctcacttg      720

aaattaccaa gtgggtttgc ac                                               742


<210> 3882
<211> 563
<212> DNA
<213> Homo sapiens

<400> 3882
ttttgttcgc cgttactctg cgcgtaagtc gcttgtccgt ggcttctctg agaagaaaag       60

ttgaaaaagg acatcgctat tgcggttccg aggcagtggg aagagatgcg gcccctggac      120

atcgtcgagc tggcggaacc ggaggaagtg gaggtgctgg agcccgagga ggatttcgag      180

cagtttctgc tcccggtcat caacgagatg cgcgaggaca tcgcgtcgct gacgcgcgag      240

cacgggcggg cgtacctgcg gaaccggagc aagctgtggg agatggacaa tatgctcatc      300

cagatcaaaa cgcaggtgga ggcctcggag gagagcgccc tcaaccacct ccagaacccg      360

ggcgacgcgg ccgagggccg ggcggccaag aggtgcgaga aggccgagga gaaggccaag      420

gagattgcga agatggcaga gatgctggtg gagctggtcc ggcggataga gaagagcgag      480

tcgtcgtgag cgcggtcggc ggtttccagc caatggattc tggtcaactg gtggagattg      540

gctgacaccc tggagaagcc gaa                                              563


<210> 3883
<211> 584
<212> DNA
<213> Homo sapiens

<400> 3883
gacgcagatg cgaaagtggc ggcctccggg caccatttct gtgcacggaa acagaatccg       60

ggtttgaaga tcttctttgt gaagctttca ttcaatggtg taccacaaaa gattgaaggt      120

catttcttta aaaagcattt gacattgtgc agcaaagaaa tggttatgga gaagcccagt      180

ccgctgcttg tagggcggga gtttgtgagg caatattata ctttgctgaa taaagctccg      240

gaatatttac acaggtttta tggcaggaat tcttcctatg ttcatggtgg agtagatgct      300

agtggaaagc cccaggaagc tgtttatggc caaaatgata tacaccacaa agtattatct      360

ctgaacttca gtgaatgtca tactaaaatt cgtcatgtgg atgctcatgc aaccttgagt      420

gatggagtag ttgtccaggt catgggtttg ctgtctaaca gtggacaacc agaaagaaag      480

tttatgcaaa cctttgttct ggctcctgaa ggatctgttc caaataaatt ttatgttcac      540

aatgatatgt ttcgttatga agatgaagtg tttggtgatt ctga                       584


<210> 3884
<211> 605
<212> DNA
<213> Homo sapiens

<400> 3884
ccgaatcgca cgcggccggg tccgctctcc cgggaggaga gcccggcgtg gaccagcgtg       60

acgaccccag cgtgctgcgg cctctccccg agggcccctc cacaagggtc cctgcgcggg      120

ccgggctcgg ccgttgccac tcgggacagc catcccctcg agttcgcgct cgccgtcccc      180

gccttcacct cccgggttgg gaggcgggcg actgcgcgcg aggtaaagga acttgcgttc      240

cccggcgccg aggcggcagc agcgcagtgc acagcggctt ctgaaggcgg cgtcgacggg      300

gagctgcgcg tggctcccag tttcctggtt acgtgcgcgc cggcagagcc aaaacctgca      360

gccgaaactc ccgcttctcc ggccagcctg cgcattctta cctgtcgggg tgcggcgagt      420

gtctcacctc tctgcacttc caaggactct tgtcatctgc cttaggcggg aaatgctgtt      480

gctggattgc aaccccgagg tggatggtct gaagcatttg ctggagacag gggcctcggt      540

caacgcaccc ccggatccct gcaagcagtc gcctgtccac ttagccgcag gaagcggcct      600

tgctt                                                                  605


<210> 3885
<211> 552
<212> DNA
<213> Homo sapiens

<400> 3885
gatacacagt ttccagaact gtctgggggc gggagcggga gcgggagccg agcccgctcg       60

gagctcctcg ccgccgctgc cgctcccatc ttaaaaccgt ttctcgccgg cgcgcccgcc      120

ccagcccgaa ggctgcctgc tgtttcccgg ggagatcatg aaacgaggtc gccttcccag      180

cagcagtgag gattctgacg acaatggcag cctgtcaact acttggtccc agaattcccg      240

atcccagcat aggagaagct cctgctccag acatgaagat cgaaagcctt cagaggtgtt      300

taggacagac ctgatcactg ccatgaagtt gcatgactcc taccagctga atccggatga      360

gtactatgtg ttggcagatc cctggagaca ggaatgggag aaaggggtcc aggtgcctgt      420

gagcccgggg accatccctc agcctgtggc cagggttgtg tctgaagaga aatccctcat      480

gttcatcagg cccaagaagt acatcgtgtc atcaggctct gagcctcccg agttgggcta      540

tgtggacatc cg                                                          552


<210> 3886
<211> 1300
<212> DNA
<213> Homo sapiens

<400> 3886
gttgcggccg ctggagcccg agccatgcgg accgcggacc gggaggcgcg cccggggctt       60

ccgtccctgc tgctgctgct gctggccggg gccgggctgt cagccgcctc gcccccagca      120

gcgccgcgct tcaacgtgag cctggactcg gtccccgagc tgcgctggct gcccgtgctg      180

cggcactacg acttggactt ggtgcgcgcc gcgatggcgc aagtcatcgg ggacagagtc      240

cccaagtggg tgcacgtgtt aatcggaaaa gtggtcctgg agctggagcg cttcctgccc      300

cagcccttca ccggcgagat ccgcggcatg tgtgacttca tgaacctcag cctggcggac      360

tgccttctgg tcaacctggc ctacgagtcc tccgtgttct gcaccagtat tgtggctcaa      420

gactccagag gccacattta ccatggtcgg aatttggatt atccttttgg gaatgtctta      480

cgcaagctga cagtggatgt gcaattctta aagaatgggc agattgcatt cacaggaact      540

acttttattg gctatgtagg attatggact ggccagagcc cacacaagtt tacagtttct      600

ggtgatgaac gagataaagg ctggtggtgg gagaatgcta tcgctgccct gtttcggaga      660

cacattcccg tcagctggct gatccgcgct accctgagtg agtcggaaaa cttcgaagca      720

gctgttggca agttggccaa gactcccctt attgctgatg tttattacat tgttggtggc      780

acgtcccccc gggagggggt ggtcatcacg aggaacagag atggcccagc agacatttgg      840

cctctagatc ctttgaatgg agcgtggttc cgagttgaga caaattacga ccactggaag      900

ccagcaccca aggaagatga ccggagaaca tctgccatca aggcccttaa tgctacagga      960

caagcaaacc tcagcctgga ggcacttttc cagtgaaagc aggccaggtg cggtggctca     1020

cgcctgtaat cccagccctt tgggaggcca aggcgggtgg atcacttgag gtcaggagtt     1080

caagaccagc ctggccaaca tggtgaaacc tcgtctctac taaaaataca aaaatcaacc     1140

aggcatgacg gtgcacgcct gttatcacag ctacttggga agcagcggct ggagaattgc     1200

ttgaacctgg gaagtcgagg ctgcaagtga gctgagatca tgccatggca gtctagcctg     1260

ggcaacagag cgagactctg tttcaaaaaa aaaaagaaaa                           1300


<210> 3887
<211> 755
<212> DNA
<213> Homo sapiens

<400> 3887
acgctaacgg cggtcgtgcc ccgccgctgc tgtcaccccc ggccgctgct gccctccccg       60

ccgaggttct actgctctcc ttcttaagaa gggtgggagg cactcggtct ctccccacac      120

ctctcgcctg aggccaggcg ccaggtgtcg cctgaagcca gacagccggt ttgggagcga      180

gcctgagggc aaggggaagg caaggggatc ttcaagagaa tgtgactgtg ggggattatg      240

gctttctggc caatttgtta cctattgaac actaagttcc aggcactggg ctaggcactg      300

ggatggtgtg gtgagcaaaa actgaccagt cctgccgtgg agtttgctgg gggagacaca      360

tgttactcaa agaatcacac taaggatagc aatttatctc aaagcttcaa gttcctgcca      420

tctacatgtg cccaggtcaa ccaatcaatg gctcagacag ataagccaac atgcatcccg      480

ccggagctgc cgaaaatgct gaaggagttt gccaaagccg ccattcgggc gcagccgcag      540

gacctcatcc agtggggggc cgattatttt gaggccctgt cccgtggaga gacgcctccg      600

gtgagagagc ggtctgagcg agtcgctttg tgtaactggg cagagctaac acctgagctg      660

ttaaagatcc tgcattctca ggttgctggc agactgatca tccgtgcaga ggagctggcc      720

cagatgtgga aagtggtgaa tctcccaaca gatct                                 755


<210> 3888
<211> 1079
<212> DNA
<213> Homo sapiens

<400> 3888
cggattcgtg aagcagttga gtgctgcagc ggcagtcgtc gcccctgccg ccgctgccac       60

cgaaggaagc atcccagaca ccgggaagat ggaagatggt accccaaagc atatcatcca      120

gatgacagga tttaagatgg aagaaaaaga agcgctagtc aaattacttt taaaactaga      180

ttgcactttt attaagagtg agaaatacaa aaattgtaca catcttatag ctgaacgcct      240

atgtaagagt gaaaaatttt tagcagcttg tgcggcagga aagtggatac taaccaagga      300

ctatataatt catagtgcca aaagtggcag atggcttgat gaaacaactt atgaatgggg      360

atataaaatt gaaaaagatt cccgttattc acctcaaatg caatctgcac ctaaaagatg      420

gcgtgaagaa ctgaaacgca ctggtgctcc aggagccttc cacagatgga aagttgtcct      480

ccttgttaga actgataagc gaagtgattc tcttataaga aagaaattca gaatgatgaa      540

gattcccaaa ccaattctgt ttggactgaa catagcaatg aagaaacaaa caaagatttc      600

aggaaagatg caggatttct tgaaatgaaa ggtgccttaa gagagaccat gtatagaacc      660

cagaaagaaa tgcaaaatca tgaagatgtt aatgttggtt ctattttgat tcaacatcac      720

aaaaaagaaa aattcagtgg ttccagtaaa gatttgaaat ttgttaaaat gagaaatacc      780

tttggaagcc atacatatga aaatcagaag gaaattaaga aaaaagatga agatattcag      840

aggagttata ctttgaggag aaaacgcaag aaaggaaaag aaagcaattg caagaaaggc      900

gttgaacatg aaaaaataaa aagtacctta agaaggcaca tatataatag agatcagaaa      960

gaaatgaaga attctatttt tgctgaatat gccaaagaat caaaagccat ggctattaag     1020

acagatgtgg atgttgttga aataaaaaat accttaagga agcacatata tagagctca      1079


<210> 3889
<211> 623
<212> DNA
<213> Homo sapiens

<400> 3889
atcccaggcg cttactcgag agctagctga gcgaatgggc cggcgactgt ggagttagcg       60

tcctcaatgt ggacgccctg agctcccatt aggagccgct ggctgcggca gcaggggact      120

agcgtgagag ttttatttcc tctatttaca gttggctaaa aaaaagaaaa gaacatggag      180

gcagatataa tcacaaatct tcgatgcagg ctcaaagagg ctgaagaaga gcgactaaaa      240

gctgcacagt atggtttaca actagtagag agtcaaaatg aattacagaa tcaattggat      300

aaatgtcgta atgaaatgat gaccatgact gagagttatg aacaagaaaa atataccctt      360

caaagagaag ttgaactcaa gagtcgaatg ttagaaagtt tgagctgcga atgtgaagct      420

attaaacaac aacaaaaaat gcacctggag aaattggaag aacaactaag cagaagccat      480

ggacaggaag tgaatgaact aaaaactaag atagaaaaac tgaaagtgga attagatgaa      540

gccaggctta gtgaaaagca gctgaagcac caagtagatc atcagaagga actcctctct      600

tgtaaatcag aggaactgcg cgt                                              623


<210> 3890
<211> 1423
<212> DNA
<213> Homo sapiens

<400> 3890
ctttgcggcc atccacgact ttcgcacctt ccgccatttt cctgcctgtg agggtggaca       60

gatcgcgctc gggtctcggc ctcctgagtg ccggtgactg cgggaggcga cggagtgctt      120

ctgggggtgt gagctgggga agttcgtggt cacggatgcg tgtggggttg ctgctcagtc      180

tgtaacggca ggtgggagac ggacactggg tggaggatgg agtgcggaaa gatgaatggg      240

agggctgatt ttcgagagcc gaatgcagag gttccaagac caattcccca catagggcct      300

gattacattc caacagagga agaaaggaga gtcttcgcag aatgcaatga tgaaagcttc      360

tggttcagat ctgtgccttt ggctgcaaca agtatgttga ttactcaagg attaattagt      420

aaaggaatac tttcaagtca tcccaaatat ggttccatcc ctaaacttat acttgcttgt      480

atcatgggat actttgctgg aaaactttct tatgtgaaaa cttgccaaga gaaattcaag      540

aaacttgaaa attcccccct tggagaagct ttacgatcag gacaagcacg acgatcttca      600

ccacctgggc actattatca aaagtcaaaa tatgactcaa gtgtgagtgg tcaatcatct      660

tttgtgacat ccccagcagc agacaacata gaaatgcttc ctcattatga gccaattcca      720

ttcagttctt ctatgaatga atctgctccc actggtatta ctgatcatat tgtccaagga      780

cctgatccca accttgaaga aagtcctaaa agaaaaaata ttacatatga ggaattaagg      840

aataagaaca gagagtcata tgaagtatct ttaacacaaa agactgaccc ctcagtcagg      900

cctatgcatg aaagagtgcc aaaaaaagaa gtcaaagtaa acaagtatgg agatacttgg      960

gatgagtgaa aaattacatc attggacatg aaggagtttc aacatccagc ttcatctagg     1020

tggtcatgat tacctgcatg ctttgagctc agcagcagtc ttcataaaca catttaaaac     1080

aagatcctgg gtttttgtgg tttgacttct atggtgtttt aaaaaaacac agatttttag     1140

tgttaatatt gtgtaaatgt actcacctta gggattcatt tgaatgatgg tattatacca     1200

tgattgtata cagtttgtga aattgttgca agggcaaaga taactcttaa aaaaccgtcg     1260

agattacaat gctctagaat cagcatataa gaaaataaat gatatctgca tgttgaattg     1320

gggtggatgg ggggagcaag cataattttt aagtgtgaag ctttgcatca agaaattatt     1380

aaaaagcttt ttttctccag tattttctgt attatcttaa tgt                       1423


<210> 3891
<211> 554
<212> DNA
<213> Homo sapiens

<400> 3891
gtgtttaatc gtcgccaagc gggacttact gcaagctatc aaatctgagg tcttattttg       60

ttgagtcgaa agtgaaattt tcctttggcc aacgtgacag ggctttgttt ggtggtaaaa      120

agggttacta gacacccctc attccactgc cactggaggg cgcatttctc agctcttgct      180

cttcaaacct gctgaaagga attcctagat ctaaacacca gtttccttca tgtccttatc      240

gcttcctgtc caaatctact gaaaacccct tcggctgtta cttctggatg tgatgtcgca      300

gtctttagcc catcctgtct gctagtgcca tctgaaatcc ttcctggaac ttgcatttga      360

cattgtgcag caaagaaatg gttatggaga agcccagtcc gctgcttgta gggcgggagt      420

ttgtgaggca atattatact ttgctgaata aagctccgga atatttacac aggttttatg      480

gcaggaattc ttcctatgtt catggtggag tagatgctag tggaaagccc caggaagctg      540

tttatggcca aaat                                                        554


<210> 3892
<211> 742
<212> DNA
<213> Homo sapiens

<400> 3892
tggcctgact cacaggacac taaggctcct tttctgaaga agccttttac cagtctcatt       60

taggggatgg gaacaacatg tcttcaccta gggactttag agcagagcct ggtttttgaa      120

aataaagtta attcagagaa ggtaaaactt tctcttcgga atttcccaca taatgattat      180

gaggatgttt ttgaagagcc ttcagaaagt ggcagtgatc ccagcatgtg gacagccaga      240

ggccccttca gaagagacag gtggagcagt gaggatgagg aggctgcagg gccatcacag      300

gctctctccc ctctactttc tgatacgcgc aaaattgttt ctgaaggaga actagatcag      360

ttggctcaga ttcggccatt aatattcaat tttcatgagc agacagccat caaggattgt      420

ttgaaaatcc ttgaggaaaa aacagcagcg tatgatatca tgcaggaatt tatggcttta      480

gaacttaaga atctgcctgg tgagttcaac tctgggaatc aaccaagcaa cagagaaaaa      540

aacagatacc gagatattct tccatttcaa catcatggat atagtggccc aaatgagaga      600

acaacgttct ggcatggttc aaacgaagga gcagtatcac ttttgttacg atattgtgct      660

tgaagttctt cggaaacttc tgactttgga ttaagaaaga cttctgttgc ctctcacttg      720

aaattaccaa gtgggtttgc ac                                               742


<210> 3893
<211> 1163
<212> DNA
<213> Homo sapiens

<400> 3893
aggcgagggg gcggagcaag agaagaaaac acaaagggcc ggaaggaagc cggggagaca       60

ggtggggtac tcgggaagct ggagcgggcc ggcggtgcag tcacggggga gcgaggcctg      120

ctgggcttgg caacgaggga ctcggcctcg gaggcgaccc agaccacaca gacactgggt      180

caaggagtaa gcagaggata aacaactgga aggagagcaa gcacaaagtc atcatggctt      240

cagcgtctgc tcgtggaaac caagataaag atgcccattt tccaccacca agcaagcaga      300

gcctgttgtt ttgtccaaaa tcaaaactgc acatccacag agcagagatc tcaaagatta      360

tgcgagaatg tcaggaagaa agtttctgga agagagctct gcctttttct cttgtaagca      420

tgcttgtcac ccagggacta gtctaccaag gttatttggc agctaattct agatttggat      480

cattgcccaa agttgcactt gctggtctct tgggatttgg ccttggaaag gtatcataca      540

taggagtatg ccagagtaaa ttccattttt ttgaagatca gctccgtggg gctggttttg      600

gtccacagca taacaggcac tgcctcctta cctgtgagga atgcaaaata aagcatggat      660

taagtgagaa gggagactct cagccttcag cttcctaaat tctgtgtctg tgactttcga      720

agttttttaa acctctgaat ttgtacacat ttaaaatttc aagtgtactt taaaataaaa      780

tacttctaat ggaacaaaaa cattgtgtct gtcactcact gaaatgtatt ccgtggaagg      840

ctttcaagtg aactaagcgt tacatgtttt tctgctcttt aagaacatgt cggggcatgg      900

cgcagtggct catgcctgta atcccagtac tttgggaggc cgaggcaggc agatcatttg      960

aggtcaggag ttcatgacca gcttggccaa catggtgaaa ccccatctct gctaaaaata     1020

taaaaattag ccaggcgtgg tggcacatgc ctgtaatccc agctactgag agggaggctg     1080

aggcaggaga atcacttgaa cccaggaggc gaaagttgca gcgagcagag attgtgccac     1140

tgcactccag cctgggtgcc aga                                             1163


<210> 3894
<211> 3020
<212> DNA
<213> Homo sapiens

<400> 3894
atgggcccct cggggaggcg aggcctgcgg gcgagccctt ctgagggcag ggggtgaggg       60

ggcggcgccc gccagccagg acagcatcct gccgccgtga caagcacgcc tccggttgcc      120

aaaacaaccc aaaaatgtgc ctcaaaacac gttcgcaaag ccccgggccg gccggtcgcc      180

tgcctctcac ctagcccgac cgcccgacgt cctactgccg agcgagggcg agcaagccaa      240

tgagtcgcaa tcccagcagc aatagcccag aagaggacac ggttcccgta ccgaagggtt      300

cagtaccagc agcccgacca tcacgcggcg ggatgtctgt ggttggcatt gacctcggct      360

ttctcaactg ctacattgct gtcgcgagaa gtggcggcat cgagaccatc gccaatgagt      420

acagcgacag gtgtaccccg gcctgtatat cattgggatc aagaactcga gccattggaa      480

atgcagcaaa gagccagata gtcacgaacg taagaaatac aattcatggc ttcaaaaagc      540

ttcatgggcg atcatttgat gatcccattg tgcaaactga aaggatcagg cttccctatg      600

aactgcagaa aatgcctaat ggaagtgcag gagttaaggt gcggtactta gaggaagaga      660

gaccttttgc aattgagcaa gttactggaa tgctgttagc caagcttaaa gagacttcag      720

aaaatgcttt gaagaaacca gtggctgact gtgtgatttc aattcctagc ttttttactg      780

atgccgagag aagatctgtg atggctgcag cccaggttgc aggcttaaat tgtttaaggt      840

tgatgaatga aactactgca gttgcactgg cgtatggaat ttataaacag gatcttcccc      900

cattagatga gaaaccaaga aatgtagtat ttattgatat gggacattct gcctatcagg      960

tcttggtttg tgcttttaac aaaggaaaac ttaaagtctt ggctactacc tttgatccat     1020

atttgggtgg caggaacttt gatgaggctt tagtagacta cttctgtgat gagttcaaga     1080

ccaaatataa gataaatgtg aaagaaaact ctcgggcctt gttgcgttta tatcaggaat     1140

gtgaaaaact aaagaagcta atgagtgcaa atgcatcaga tcttccattg aacattgagt     1200

gtttcatgaa tgaccttgat gtttctagta aaatgaacag ggctcaattt gaacaactgt     1260

gtgcttccct tttggccagg gttgaaccac ctttaaaagc agtaatggaa caagctaact     1320

tacaacgtga agacattagt agtatagaaa ttgtaggagg agcaacacga attcctgcag     1380

tgaaagaaca aatcactaaa ttctttctta aagacataag taccacatta aatgctgatg     1440

aagctgttgc aagaggatgt gcgttacagt gtgcgattct ctcaccagca tttaaagtgc     1500

gtgaattttc cataacagac cttgttccct attcaatcac attaaggtgg aagacctctt     1560

ttgaagatgg aagtggggaa tgtgaagttt tctgtaagaa ccatcctgcc ccattctcaa     1620

aagtcattac tttccacaag aaggaaccat ttgaactaga agcattttat actaatttac     1680

atgaagtgcc ttatcctgat gcaagaattg ggagcttcac tattcagaat gtttttccac     1740

agtctgatgg tgatagttcc aaagtgaagg ttaaagttcg tgttaacatc catggaatct     1800

tcagtgtggc tagcgcatca gtaattgaga agcaaaattt ggaaggcgat cacagtgatg     1860

ctccaatgga gacagaaact tcatttaaaa atgaaaacaa agataatatg gataaaatgc     1920

aggttgatca agaagaaggg catcaaaaat gtcatgctga acacactcca gaagaggaaa     1980

ttgatcatac aggagccaaa acaaagtcag ctgtctcaga caaacaagac cgattaaatc     2040

agacacttaa aaaaggaaaa gtcaaaagta ttgatctacc gatccagagt agcctatgta     2100

gacaactagg ccaagatctt ctcaacagct acattgaaaa tgaggggaag atgatcatgc     2160

aagataagtt agagaaagaa agaaatgatg ctaagaatgc cgttgaagaa tatgtatatg     2220

attttagaga caggctgggc actgtctatg aaaaattcat cactccagaa gacttgagta     2280

aactgtctgc agtattggaa gacacagaaa attggcttta tgaagacgga gaggaccaac     2340

ctaaacaagt ttatgtggat aagcttcaag aactaaagaa atacggccag cctattcaaa     2400

tgaagtacat ggagcatgaa gagagaccaa aagccttaaa tgacttggga aaaaagatcc     2460

aacttgtcat gaaagtgata gaagcttata gaaacaagga tgaaagatat gatcatctgg     2520

atcctactga aatggaaaag gttgaaaaat gtatcagtga tgccatgagt tggctgaata     2580

gtaagatgaa tgcacagaac aaactaagtc tcactcaaga tcctgtggta aaagtttcag     2640

aaatagtagc aaagtcaaag gaactggata atttctgtaa ccccatcatt tacaagccca     2700

aaccaaaagc agaagttcct gaagacaaac caaaagctaa tagtgaacac aatggcccaa     2760

tggatggaca gagtggaact gaaactaaat cagattcaac aaaagacagc tcacagcata     2820

ctaaatcctc tggagagatg gaagtggact aagtcttaat tttaccttca cattaattca     2880

aaccgtgcaa gtaaccacgg ggtccatctt ttacatctgg tacacacaac agacgctcag     2940

ttgttcttaa ccacttttgt catttgtttt ttggagtagt tttgaaaagt gttttatatt     3000

gagtgcactt ctgttcattt                                                 3020


<210> 3895
<211> 542
<212> DNA
<213> Homo sapiens

<400> 3895
agctcagctc agacggcgcc ctagggccgc acagagggtc gggcagtgcc ggagagaggt       60

ttgaaagcgc cgccgccaac tcgacagcgc gtcccaggaa aaactgagga aacgcgcctg      120

gttccagggg tcggcgggga ccgtggagac gctgccagca tcctcaacag cttggaaatc      180

ccatcacctt ggttccctga gacttggagg actagtagga actgacagct ggctgacaga      240

aaacttatcc agggagagaa gagacaaaag tgaagtgtga aattttgaat aatgttttca      300

ggcacggccg tcgccagcat agtaccggct cctcttcttc tcccagaacc tcctgacacc      360

aaccttggtg aaagaaaagc tgtgacaatg ctttgcattc agaatagacc tctgagttgg      420

gacccaagct gtcaactgat cccaaattcc taagttcctg acttgcaggt attgagttct      480

aacctccgaa gatggatgaa ggtatggaaa tttcaagtga aggaaattcc ttgatcaaag      540

ca                                                                     542


<210> 3896
<211> 3897
<212> DNA
<213> Homo sapiens

<400> 3896
ccttttgcct tcaaccttcg agccgccacg taatgccacg tccccgcgca tgcgcatctt       60

ggccgctgct ggcggctgtt tccgggctta gagggctgga gtggccgccg agttggaggc      120

ggtggtggca gcagtaggag tgtgtagagt gcgggattgg ggcccaggcc ctgcggaggg      180

cgggggaagt tgtcttcttt tttttccgga ggggccggta aacctggtgg ctgaacggca      240

agatgaattt cctccgcggg gtaatggggg gtcagagtgc cggaccccag cacacagaag      300

ccgagacgtt cagattctga aataataggt tatgctttgg acacactata taatataata      360

tctaatgaag aagaagaaga agtagaagaa aattccacaa gacagagtga agatttggga      420

agccaattta cagaaatttt cattaagcag caggaaaatg tcactcttct gttatcttta      480

ttggaggagt ttgatttcca tgtccgctgg cctggtgtga agcttcttac ttctctttta      540

aaacaactag ggcctcaggt gcaacaaatt attttagtca gtcctatggg tgtttcaaga      600

ttgatggact tactagcgga ttccagggaa gttatacgta atgatggcgt cttactactg      660

caggcactaa caagaagcaa tggtgcaatc cagaaaattg ttgcttttga aaatgctttc      720

gagagactac tggacattat ttcagaggag gggaacagtg atggaggtat agtagttgaa      780

gattgtttga ttttgctcca aaacttatta aaaaacaaca actccaatca aaattttttt      840

aaagaaggct catatattca acgtatgaaa ccttggtttg aagttggaga tgaaaattct      900

ggctggtctg cacagaaagt gaccaatcta catctaatgc tacagcttgt tcgtgtattg      960

gtatctccca ccaaccctcc tggtgctacc agtagctgcc agaaggctat gttccagtgt     1020

gggttattgc agcagctttg tactatccta atggctactg gggttcctgc tgatatcctg     1080

actgagacca taaatactgt atcagaagtt attcgaggct gccaagtaaa ccaagactac     1140

tttgcatctg taaatgcacc ttcaaaccca ccaagaccgg caattgtagt acttctcatg     1200

tccatggtta atgaaaggca gccatttgtt ttgcgctgtg ctgttctcta ttgtttccag     1260

tgtttcttgt ataaaaacca aaaaggacaa ggagaaatcg tgtcaacact tttaccttct     1320

accattgatg caacaggtaa ttcagtttca gctggccagt tattatgtgg aggtttgttt     1380

tctactgatt cactttcaaa ctggtgtgct gctgtggccc ttgcccatgc gttgcaagaa     1440

aatgccaccc agaaagaaca gttgctcagg gttcaacttg ctacaagtat tggcaaccct     1500

ccagtttctt tacttcaaca gtgcaccaat attctttcac agggaagcaa aatacaaaca     1560

agagttggat tattaatgtt gctttgtacc tggctaagca attgtcccat tgcagtaacg     1620

cattttcttc acaattcagc caatgttcca tttcttacag gacaaattgc agaaaatctt     1680

ggagaagaag agcagttggt ccaaggctta tgtgcccttt tgttgggcat ttcgatttat     1740

ttcaatgata actcacttga gagctacatg aaagagaagc taaaacaact gattgagaag     1800

aggattggca aagagaattt catagagaaa ctaggattta ttagcaaaca tgagttgtat     1860

tccagagcat ctcagaaacc ccagccaaac tttcccagtc cagaatacat gatatttgat     1920

catgagttta cgaagctggt aaaagaactt gaaggtgtta taactaaggc tatttataag     1980

tccagtgaag aagataaaaa agaagaagag gtgaaaaaaa cattagaaca gcatgacaat     2040

attgtgactc actacaaaaa tatgattcga gagcaggatc tccaacttga ggaattaagg     2100

cagcaggttt ctacattaaa atgtcaaaat gaacagctcc agacggcagt cacacagcaa     2160

gtatcacaga tccagcagca caaagaccag tataatcttc ttaaaataca gctaggaaaa     2220

gacaatcagc atcaaggttc ttacagtgag ggggctcaga tgaatggcat tcagccagaa     2280

gaaattggta gattgcgaga agagatagaa gaattaaaac gtaatcagga acttttacaa     2340

agccagctga ctgaaaagga ctctatgatt gaaaatatga aatcttccca aacatctggc     2400

acaaatgaac agtcttcagc aatagtttca gctagagatt ctgaacaagt tgcagaatta     2460

aaacaggaac tggcaacttt aaagtctcag ttaaactcac aatctgtgga gatcaccaaa     2520

ctacagacag aaaagcagga actgttacag aaaacagaag cgtttgcaaa atcagttgag     2580

gtacaaggag agaccgagac tataatagcc accaaaacta ctgatgtaga aggaagactg     2640

tcagcattat tacaagagac caaagagtta aagaatgaaa ttaaagctct gtctgaggaa     2700

agaactgcca ttaaagagca gctggattca tctaatagta ccattgccat tttacaaact     2760

gagaaagaca aactagagtt ggaaattaca gattctaaaa aagaacaaga tgatctcttg     2820

gtgctcttgg ccgatcaaga tcagaaaata ctgtcattga agaataaact caaggatctt     2880

ggtcatccag ttgaagaaga ggatgaactt gaatctggag accaagagga tgaggatgat     2940

gaaagtgaag atcctggcaa ggatctagat catatctagt tttcaaatct ctaggaacaa     3000

tagagattat atcataactc tgaagatgga ctctaaactt tggtttacct ccatggaaaa     3060

taaagattta gaaaccaggt ggaaaacatt cactattaag actattgata tatttttgta     3120

atgttgccac ccatgttgaa aaccttaaaa ctgaatttat gtagaacaca catcttttat     3180

ttaaatccat ctgaactgtc ccaaaatgta atttgcaaag agcttcaaac accaaaaata     3240

taccatttta aggcatgtgg tgacaatgct atttgcctta gttcattcgt tgtttacttt     3300

gcaaaatttg tgacttttaa gtactaacac atttgattga atgtgtattg aattggaatt     3360

attatttcta aattcagcat ttgagtcctt agttgatgat tttcttttaa agaaattagt     3420

ttatttaaaa gcaagatagc ctgggttggg agttagtgca tatcatcagc cctccatcta     3480

atgtgattgc taagatgtgc aggataggac agcttagaat gagtgccttg acacctacat     3540

atggctgcat tccatacctc agtgaagaag ccgaaggatg ctgacacaca gtgatgtgga     3600

gggcattccg gagaaacttt tgcaacagtg tattaatgtg attggttttc tttttgtttt     3660

aagctaaaca tctaaaacaa atttcaagtt aacagttcat acaactcaga tttagtagta     3720

ttgtttatca taaaacatat tatgttccta gttttaaaaa gacccaaagt atgattaata     3780

taatttattg gcatttttgc tgaataggtt taagtcagat aatagatttt aaaaaagcaa     3840

atgaggcaat gtgtcaaaat ttaatgtttc ataataaaaa tagatacgtt gacttaa        3897


<210> 3897
<211> 631
<212> DNA
<213> Homo sapiens

<400> 3897
tgaggcacct tcgggcaaca cccaatactc ggggctccgc tcggcttctt tgcgccgaga       60

tgcctaagaa ggctggtgcg acgaccaagg gtaaaagcca gagcaaggaa ccagagagac      120

cacttcctcc cttaggtcct gtggcagttg atcctaaagg atgcgtcacc atagccatcc      180

atgcaaaacc tggctccaaa caaaatgctg taacagattt gacagcagag gctgtaaatg      240

tagctattgc agcacctcca tcagagggag aggctaatgc tgagctctgt cggtatcttt      300

ccaaggtcct agaactcagg aagagtgatg tggttttgga taagaagttg agagacttac      360

tcaagattgt accatgcaag ctggcaacta gaacccaaat ccttggacta cttgttgaat      420

gcagtttttc tagattgtaa attaaaaatc atatctccac aacggttctg gaattctggg      480

gattgccttc taatccagtt tacaagtgac agaaaacctg ttatgctgct ttgtagtctt      540

accttagatt tttaaatgct tatttaaatg taaaaaaaat ttttttttta catcttttaa      600

agactatatt taccattttg ttgaaaaagt a                                     631


<210> 3898
<211> 348
<212> DNA
<213> Homo sapiens

<400> 3898
agtgcctccg ggtcgcggtc attttgagcc cctgtctgga tgacttcttg cggctgttct       60

acccctcccc ctccccgcgt cgcctgctgc tgtcgtcggg aggaaagatg aatgggaggg      120

ctgattttcg agagccgaat gcagaggttc caagaccaat tccccacata gggcctgatt      180

acattccaac agaggaagaa aggagagtct tcgcagaatg caatgatgaa agcttctggt      240

tcagatctgt gcctttggct gcaacaagta tgttgattac tcaaggatta attagtaaag      300

gaatactttc aagtcatccc aaatatggtt ccatccctaa acttatac                   348


<210> 3899
<211> 504
<212> DNA
<213> Homo sapiens

<400> 3899
gctaaagatt cctggagtag ttatagtaat aatgtcacag gaatatagaa agaaacctgg       60

catctttggg agacctactg atatgtgact tctccacccc tccccctcct tttttaacct      120

ggctgcctgc tgtttcccgg ggagatcatg aaacgaggtc gccttcccag cagcagtgag      180

gattctgacg acaatggcag cctgtcaact acttggtccc agaattcccg atcccagcat      240

aggagaagct cctgctccag acatgaagat cgaaagcctt cagaggtgtt taggacagac      300

ctgatcactg ccatgaagtt gcatgactcc taccagctga atccggatga gtactatgtg      360

ttggcagatc cctggagaca ggaatgggag aaaggggtcc aggtgcctgt gagcccgggg      420

accatccctc agcctgtggc cagggttgtg tctgaagaga aatccctcat gttcatcagg      480

cccaagaagt acatcgtgtc atca                                             504


<210> 3900
<211> 589
<212> DNA
<213> Homo sapiens

<400> 3900
gcagttcttg agttccacat gcagagcaga tgcgacagct agaagtgagt agggcccaga       60

ccctggccca ggaagatcca ctaaaggagg ccatccttcc gccttcttct gcaggagtca      120

gggggcgtgt aaaggtgatt tgttcgccaa gaaaagcact tttagtaaag cacagatgtt      180

aatctagatc atggaaaagt gccacacact agatttagca cataagcaag gagtctctag      240

aacactcaga agaaaatgaa tgaatccatg aatgaatgga caagtgagag cccagagcag      300

ctgaagccat gaagtgcttt ggaaagagaa gcgtgcctgg gaaaagagag tggctgagtg      360

ctaagagcag ggtgaacacc atggaaaact tgaaattgaa aacatcacaa ttttaatgag      420

aaaaagcgca acccaaagtg aagagcacca ttataacaaa ggtcatgcag gctgagtgaa      480

ttatcctaaa caaatgatgg aaaggcagat gtaaagtccc tcatggcgaa atataacacg      540

gggggcaacc cgacagagga tgtctcagtc aatagccgac ccttcagag                  589


<210> 3901
<211> 2273
<212> DNA
<213> Homo sapiens

<400> 3901
attctcctgc ctcagcctcc cgagttgctg ggactacagg ggtgcaccac ctacgcccgg       60

ctaatttttt tgtattttta gtagagaacg gggtttcacc gtgttagcca ggatggcctc      120

gatctcttga cctcgtgatc cgcccgcctc ggctgcccaa agtgctggga ttacaggcgt      180

gagccaccgc gcccggccga aaggggggat attaatcatt actccaggac gacagaggga      240

aaatcgcttt gtactggaca aactggaatg tctgaccaac cattataaag tgcacggagt      300

gggaggagga atagggacat tttaattgta tttctaaaaa gtatcttctg tggtgaatcg      360

gaaacaaaac tcattcttta ccacaggcag tttaagcgct gcctgaaaga tcgaaggacg      420

gtaaaccaca gacgtgagaa acggaacttt gcgaaaacgc agtcgtttta tgtaccggct      480

actcattgga gttacaccag agactcacta ctggagttca tcagccaatc caaagtccaa      540

gcgtgagagc cagagcctgt aggagagacc tgggcaggcc tcagacctga ggagtggagc      600

tccgcatcac tcaaccctgg gggcggagct agcccaggct cccacacccg acgctctggc      660

ccacacagac gctactctgt agcatctcag gttccctctg gctgcactct ggaggaccac      720

actcgttttc tttttggctg ccagaggccc ccgcatccac cgctgagctg ggagaaagat      780

ggcggcagcc gtgcgacagg atttggccca gctcatgaat tcgagcggct ctcataaaga      840

tctggctggc aagtatcgtc agatcctgga aaaagccatt cagttatctg gagcagaaca      900

actagaagct ttgaaagctt ttgtggaagc aatggtaaat gagaatgtca gtctcgtgat      960

ctcgcggcag ttgctgactg atttttgcac acatcttcct aacttgcctg atagcacagc     1020

caaagaaatc tatcacttca ccttggaaaa gatccagcct agagtcattt catttgagga     1080

gcaggttgct tccataagac agcatcttgc atctatatat gagaaagaag aagattggag     1140

aaatgcagcc caagtgttgg tgggaattcc tttggaaaca ggacaaaaac agtacaatgt     1200

agattataaa ctggagactt acttgaagat tgctaggcta tatctggagg atgatgatcc     1260

agtccaggca gaggcttaca taaatcgagc atcgttgctt cagaatgaat caaccaatga     1320

acaattacag atacattata aggtatgcta tgcacgtgtt cttgattata gaagaaaatt     1380

cattgaagct gcacaaaggt acaatgagct ctcttacaag acaatagtcc acgaaagtga     1440

aagactagag gccttaaaac atgctttgca ctgtacgatc ttagcatcag cagggcagca     1500

gcgttctcgg atgctagcta ctctttttaa ggatgaaagg tgccagcaac ttgctgccta     1560

tgggatccta gagaaaatgt atctagatag gatcatcaga ggaaatcaac ttcaagaatt     1620

tgctgccatg ctgatgcctc accaaaaagc aactacagct gatggttcca gcatcttgga     1680

cagagctgtt attgaacaca atttgttgtc tgcaagcaaa ttatataata atattacctt     1740

cgaagaactt ggagctcttt tagagatccc tgcagctaag cacgagaagc cctgccaacg     1800

tgggataagc agatccaatc actttgtttc caagtgaata accttttgga gaaaattagt     1860

caaacagcac cagaatggac agcacaagcc atggaagccc agatggctca gtgaatcctt     1920

gcagaacttc tgtgcacatg acatcttttt ccatgttgtg cagatcagtt tcactatctc     1980

caaagcattt gcatcatgac cttatacatt tcaatccctt ttatgctgga ttccgtttaa     2040

agaagacatt attagagcag gaagtacaag catttaaaat atgtagttcc catatatttc     2100

agggtctctg tgtattaagc taactcagat gttttgaaag ctttttcttt aaacagaggt     2160

gaaatatctg tggctaaaaa gtttgagatt tgtgataact ttgtagtcat gtaaaactta     2220

agtgcttcat gcctctccaa atgtggttat tctaataaat ggagaaatga gcc            2273


<210> 3902
<211> 514
<212> DNA
<213> Homo sapiens

<400> 3902
ttggggatga ggtggcgaag tgggggggga ggcacgcagc agctcccgaa ggcgcgctga       60

tggaagctta atacaggaag tgtgggagca ggctttctgg aggggatgtt ttaggcattt      120

gacattgtgc agcaaagaaa tggttatgga gaagcccagt ccgctgcttg tagggcggga      180

gtttgtgagg caatattata ctttgctgaa taaagctccg gaatatttac acaggtttta      240

tggcaggaat tcttcctatg ttcatggtgg agtagatgct agtggaaagc cccaggaagc      300

tgtttatggc caaaatgata tacaccacaa agtattatct ctgaacttca gtgaatgtca      360

tactaaaatt cgtcatgtgg atgctcatgc aaccttgagt gatggagtag ttgtccaggt      420

catgggtttg ctgtctaaca gtggacaacc agaaagaaag tttatgcaaa cctttgttct      480

ggctcctgaa ggatctgttc caaataaatt ttat                                  514


<210> 3903
<211> 1204
<212> DNA
<213> Homo sapiens

<400> 3903
attcctaggc tgctggctct cagacccgca gtgaggtctg acgtcatttc ctgccgaaag       60

atgaatggga gggctgattt tcgagagccg aatgcagagg ttccaagacc aattccccct      120

gtgcctttgg ctgcaacaag tatgttgatt actcaaggat taattagtaa aggaatactt      180

tcaagtcatc ccaaatatgg ttccatccct aaacttatac ttgcttgtat catgggatac      240

tttgctggaa aactttctta tgtgaaaact tgccaagaga aattcaagaa acttgaaaat      300

tccccccttg gagaagcttt acgatcagga caagcacgac gatcttcacc acctgggcac      360

tattatcaaa agtcaaaata tgactcaagt gtgagtggtc aatcatcttt tgtgacatcc      420

ccagcagcag acaacataga aatgcttcct cattatgagc caattccatt cagttcttct      480

atgaatgaat ctgctcccac tggtattact gatcatattg tccaaggacc tgatcccaac      540

cttgaagaaa gtcctaaaag aaaaaatatt acatatgagg aattaaggaa taagaacaga      600

gagtcatatg aagtatcttt aacacaaaag actgacccct cagtcaggcc tatgcatgaa      660

agagtgccaa aaaaagaagt caaagtaaac aagtatggag atacttggga tgagtgaaaa      720

attacatcat tggacatgaa ggagtttcaa catccagctt catctaggtg gtcatgatta      780

cctgcatgct ttgagctcag cagcagtctt cataaacaca tttaaaacaa gatcctgggt      840

ttttgtggtt tgacttctat ggtgttttaa aaaaacacag atttttagtg ttaatattgt      900

gtaaatgtac tcaccttagg gattcatttg aatgatggta ttataccatg attgtataca      960

gtttgtgaaa ttgttgcaag ggcaaagata actcttaaaa aaccgtcgag attacaatgc     1020

tctagaatca gcatataaga aaataaatga tatctgcatg ttgaattggg gtggatgggg     1080

ggagcaagca taatttttaa gtgtgaagct ttgcatcaag aaattattaa aaagcttttt     1140

ttctccagta ttttctgtat tatcttaatg tttatggcaa ataaaatgta aaggaacatg     1200

caac                                                                  1204


<210> 3904
<211> 563
<212> DNA
<213> Homo sapiens

<400> 3904
cattttgagc ccctgtctgg atgacttctt gcggctgttc tacccctccc cctccccgcg       60

gtaccttgca cttttctccc tccctgcccc ctctcgagtc caccctccgg gccttctgcc      120

cctgatcgct tggttttcct tgcagtcgcc tgctgctgtc gtcgggaggt gggtgaggtg      180

acgcaaacag ccccgttgtt gccctccgcg tatcccctca ccacctttgc ggccatccac      240

gactttcgca ccttccgcca ttttcctgcc tgtgagggtg gacagatcgc gctcgggtct      300

cggcctcctg agtgccggaa agatgaatgg gagggctgat tttcgagagc cgaatgcaga      360

ggttccaaga ccaattcccc acatagggcc tgattacatt ccaacagagg aagaaaggag      420

agtcttcgca gaatgcaatg atgaaagctt ctggttcaga tctgtgcctt tggctgcaac      480

aagtatgttg attactcaag gattaattag taaaggaata ctttcaagtc atcccaaata      540

tggttccatc cctaaactta tac                                              563


<210> 3905
<211> 788
<212> DNA
<213> Homo sapiens

<400> 3905
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct      540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaata gataccgaga      600

tattcttcca tttcaacatc atggatatag tggcccaaat gagagaacaa cgttctggca      660

tggttcaaac gaaggagcag tatcactttt gttacgatat tgtgcttgaa gttcttcgga      720

aacttctgac tttggattaa gaaagacttc tgttgcctct cacttgaaat taccaagtgg      780

gtttgcac                                                               788


<210> 3906
<211> 616
<212> DNA
<213> Homo sapiens

<400> 3906
aagcgcttga cttgcttcca gacaaaggtt gtctcaagtt tgttgctcaa accgagttct       60

ggagaacgcc atcagctcgc tgcttaaagg gaaatgctgt tgtgagagag aatgaggaga      120

gaactaggta aggctgtgag agccatcaga cctcgatgca agtccacccg cgagggagga      180

aaagaaggaa accaggttga gtggaagcat cccagacagc tgtgcagtct aagagaactt      240

cagcaagatt aaaccacagg ttccattatg ggtcgacttg atgggaaagt catcatcctg      300

acggccgctg ctcaggggat tggccaagca gctgccttag cttttgcaag agaaggtgcc      360

aaagtcatag ccacagacat taatgagtcc aaacttcagg aactggaaaa gtacccgggt      420

attcaaactc gtgtccttga tgtcacaaag aagaaacaaa ttgatcagtt tgccaatgaa      480

gttgagagac ttgatgttct ctttaatgtt gctggttttg tccatcatgg aactgtcctg      540

gattgtgagg agaaagactg ggacttctcg atgaatctca atgtgcgcag catgtacctg      600

atgatcaagg cattcc                                                      616


<210> 3907
<211> 718
<212> DNA
<213> Homo sapiens

<400> 3907
acttcgtttg tggctaaggt tactgtaagc ttttcactta aaaacttttc ctacttcttt       60

accagataag aaaacagcta attttaatca ctggcttttg ttctctagga cttaactgca      120

tcccatatta cgtatttaat gagcttgaaa aaatctcagt gtttttctta tcgtttttga      180

ccctaaatat ttaaggtgac ccaatgaaag aagaaaatga aagccataaa gaaaagtctt      240

acagaagaag aatacctgta cctggacttt tctcaccaaa cagaaggatg catctttcct      300

cttcatacat ctgtaacttt atttctgtta tcttactgtg actgtaaaat ctttaaaatt      360

tgcttagttg tcaccaaaga ggtgagtaga gatagttcac tactaagaga tgacctgatc      420

caggatgttg aaatacagat tatttcaagg caggagctcc caccaatagt ccaaaattgc      480

tgtttgcctg cagtagtaga acgatcagac aatttttgta gagcaggact tgctgttgta      540

ttgagacaca taatccagaa atcctatgaa gcagacccct taaagaagga acttttggaa      600

cttctgggct ttaaaaagac ttgcttgaaa gcctgtgctg aagttagtca gtggaccagg      660

ctatgtgaac tcaccatccc tttggctatt gagaattttc tcagagaatc ttctgacc        718


<210> 3908
<211> 2480
<212> DNA
<213> Homo sapiens

<400> 3908
agtttctcct ttgttttacg tttgggagga ggtggcattg gaaatagcag agtgcttcgc       60

ggtaacaggg acaaatgtac tgaggctgga gcctgtgtga acagaacaga agaggccttc      120

actctagtag tgctcacagt ccagcaggtg tttgctgaag acagcttact cagatcacta      180

ctgcctggag gtggttgata tatcctggtg taaaccttca agaagggcac aggcaggaaa      240

acatgagcca gcaactgaag aaacgggcaa agacaagaca ccagaaaggc ctgggtggaa      300

gagcccccag tggggctaag cccaggcaag gcaagtcaag ccaagacctg caggcggaaa      360

tagaacctgt cagcgcggtg tgggccttat gtgatggcta tgtgtgctat gagcctggcc      420

ctcaggctct cggaggggat gatttctcag actgttacat agaatgcgtc ataaggggtg      480

agttttctca acccatcctg gaagaggact cactttttga gtccttggaa tacctaaaga      540

aaggatcaga acaacagctt tctcaaaagg ttttcgaagc aagctccctt gaatgttctt      600

tggaatacat gaaaaaaggg gtaaagaaag agcttccaca aaagatagtt ggagagaatt      660

cgcttgagta ttctgagtac atgacaggca agaagcttcc gcctggagga atacctggca      720

ttgacctatc agatcctaaa cagctcgcag aatttgctag aaagaagccc cccataaata      780

aagaatatga cagtctgagc gcaatcgctt gtcctcagag tggatgcact aggaagttga      840

ggaatagagc tgccctgaga aagcatctcc tcattcatgg tccccgagac cacgtctgtg      900

cggaatgtgg gaaagcgttc gttgagagct caaaactaaa gagacatttc ctggttcata      960

ctggagagaa gccgtttcgg tgcacttttg aagggtgcgg aaagcgcttc tctctggact     1020

ttaatttgcg tacgcacgtg cgcatccaca cgggggagaa acgtttcgtg tgtccctttc     1080

aaggctgcaa caggaggttt attcagtcaa ataacctgaa agcccacatc ctaacgcatg     1140

caaatacgaa caagaatgaa caagagggaa agtagtcctc caacaggatg aagcagatta     1200

acagaagagt gatcagtgac aaacatgcct cattgattat tgtttctagg aaggaatttc     1260

taaatcaata ttgcaacccc aaaagcggtt ataatttggt gttactaaga tgctcctaca     1320

ctttgtgata ccgttttaag gacatggtgc attttttttt cttttatttg ttttatttag     1380

aacttttttt atttgtttta tttagaactt tgtgtgttct taaagtgtgc ttccaacagg     1440

aaggtcagtg ataaattttc aaaagcataa ccttcaatat attatctgtt ggattattgg     1500

atataagact tattttcatg tactataaat atgaaaataa ctttgatttt taattgtgta     1560

gtttccattt cttagctttt gccttttaaa tttatacttc agccaggcat agtgactgat     1620

gcctgtaatc ccaacacttt gttgggaggc caaagcagga ggatagcttg aggccaggag     1680

ttccagacca gcctgggcaa catagtgaga tcctgtctct acaaaaaaat ttgtttttat     1740

ttgtatttat atatttttat ttttgttttt gttggtaggc gtctcgctct gtcacccagg     1800

ctggagtcta gtgtcgtgat cttggctcac tgcaacctcc acctcccggg ttcaagtgat     1860

tctctggcct cagcctccca agtagctggg actacaggtg tgtgtcacca cgcccggcta     1920

atttttgtat ttttagtaga gatggggttt caccatgttg gccaggctag tctcaaactc     1980

ctgacctcca gtgatctgcc cacctcggcc tcccaaagtg ctgggattac aggtgtgagc     2040

cactgtgcct ggccccccac aacatgttta aacttagcta ggcctggttg catacgcctg     2100

tgttcccagc tactcaggag gctgaagcag gaggatagct tgagcccagg agtttgaggc     2160

tacagtgagc tgtgattgca ccactgtact ccagactgga taacagcaag agcccatctt     2220

ttaaaaaaag taaaaattaa aaatatactt catggttcat gtcatagccc tagagaatga     2280

aaaatttgca gtagatagtc aataaatgaa tcagtagtta aatattcctt aaagtcaact     2340

gtatttcatt gtgatttttg ttttcttttt atcattgtat caaactatat ggaaatcata     2400

tggttagatg tgattatttg ataatgttag tccatttgaa tccattttag atatttcaca     2460

attaaagaat atgaaacttc                                                 2480


<210> 3909
<211> 559
<212> DNA
<213> Homo sapiens

<400> 3909
cccacgtggt ggaagcccgg ccctgcaggc tggagaggat ttgattagac tacgcgtttc       60

gacttgcagg gtgtttaatc gtcgccaagc gggacttact gcaagctatc aaatctgagg      120

tcttattttg ttgagtcgaa agtgaaattt tcctttggcc aacgtgacag tttccttcat      180

gtccttatcg cttcctgtcc aaatctactg aaaacccctt cggctgttac ttctggatgt      240

gatgtcgcag tctttagccc atcctgtctg ctagtgccat ctgaaatcct tcctggaact      300

tgcatttgac attgtgcagc aaagaaatgg ttatggagaa gcccagtccg ctgcttgtag      360

ggcgggagtt tgtgaggcaa tattatactt tgctgaataa agctccggaa tatttacaca      420

ggttttatgg caggaattct tcctatgttc atggtggagt agatgctagt ggaaagcccc      480

aggaagctgt ttatggccaa aatgatatac accacaaagt attatctctg aacttcagtg      540

aatgtcatac taaaattcg                                                   559


<210> 3910
<211> 945
<212> DNA
<213> Homo sapiens

<400> 3910
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtgaacaa aaattgtttg ctggccccca ggatactaac tagacctttg gcctgactca      120

caggacacta aggctccttt tctgaagaag ccttttacca gtctcattta ggggatggga      180

acaacatgtc ttcacctagg gactttagag cagagcctgt aaacgattat gagggaaatg      240

actctgaagc agaagacttg aatttcaggg agactttgcc ttcatcaagt caggaaaaca      300

cacctagatc aaaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc      360

ggaatttccc acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg      420

atcccagcat gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg      480

aggaggctgc agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg      540

tttctgaagg agaactagat cagttggctc agattcggcc attaatattc aattttcatg      600

agcagacagc catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata      660

tcatgcagga atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga      720

atcaaccaag caacagagaa aaaaacagat accgagatat tcttccattt caacatcatg      780

gatatagtgg cccaaatgag agaacaacgt tctggcatgg ttcaaacgaa ggagcagtat      840

cacttttgtt acgatattgt gcttgaagtt cttcggaaac ttctgacttt ggattaagaa      900

agacttctgt tgcctctcac ttgaaattac caagtgggtt tgcac                      945


<210> 3911
<211> 1244
<212> DNA
<213> Homo sapiens

<400> 3911
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg aatttcccac      120

ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat cccagcatgt      180

ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag gaggctgcag      240

ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt tctgaaggag      300

aactagatca gttggctcag attcggccat taatattcaa ttttcatgag cagacagcca      360

tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc atgcaggaat      420

ttatggcttt agaacttaag aatctgcctg gtgagttcaa ctctgggaat caaccaagca      480

acagagaaaa aaatagatac cgagatattc ttccatatga ttcaacacgc gttcctcttg      540

gaaaaagcaa ggactacatc aatgctagtt atattagaat agtcaattgt ggagaagagt      600

atttttatat cgctactcaa ggaccactgc tgagcaccat agatgacttt tggcaaatgg      660

tgttggaaaa taattcaaat gttattgcca tgataaccag agagatagaa ggtggaatta      720

tcaaatgcta ccattactgg cccatttctc tgaagaagcc attggaattg aaacacttcc      780

gtgtattcct ggagaactac cagatacttc aatatttcat cattcgaatg tttcaagttg      840

tggagaagtc cacgggaact agtcactctg taaaacagtt gcagttcacc aagtggccag      900

accatggcac tcctgcctca gcagatagct tcataaaata tattcgttat gcaaggaaga      960

gccaccttac aggacccatg gttgttcact gcagtgccgg cataggccgg acaggggtgt     1020

tcctatgtgt ggatgtcgtg ttctgtgcca tcgtaaagaa ctgttcattc aacatcatgg     1080

atatagtggc ccaaatgaga gaacaacgtt ctggcatggt tcaaacgaag gagcagtatc     1140

acttttgtta cgatattgtg cttgaagttc ttcggaaact tctgactttg gattaagaaa     1200

gacttctgtt gcctctcact tgaaattacc aagtgggttt gcac                      1244


<210> 3912
<211> 1401
<212> DNA
<213> Homo sapiens

<400> 3912
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtgaacaa aaattgtttg ctggccccca ggatactaac tagacctttg gcctgactca      120

caggacacta aggctccttt tctgaagaag ccttttacca gtctcattta ggggatggga      180

acaacatgtc ttcacctagg gactttagag cagagcctgg tttttgaaaa taaagttaat      240

tcagagaagg taaaactttc tcttcggaat ttcccacata atgattatga ggatgttttt      300

gaagagcctt cagaaagtgg cagtgatccc agcatgtgga cagccagagg ccccttcaga      360

agagacaggt ggagcagtga ggatgaggag gctgcagggc catcacaggc tctctcccct      420

ctactttctg atacgcgcaa aattgtttct gaaggagaac tagatcagtt ggctcagatt      480

cggccattaa tattcaattt tcatgagcag acagccatca aggattgttt gaaaatcctt      540

gaggaaaaaa cagcagcgta tgatatcatg caggaattta tggctttaga acttaagaat      600

ctgcctggtg agttcaactc tgggaatcaa ccaagcaaca gagaaaaaaa tagataccga      660

gatattcttc catatgattc aacacgcgtt cctcttggaa aaagcaagga ctacatcaat      720

gctagttata ttagaatagt caattgtgga gaagagtatt tttatatcgc tactcaagga      780

ccactgctga gcaccataga tgacttttgg caaatggtgt tggaaaataa ttcaaatgtt      840

attgccatga taaccagaga gatagaaggt ggaattatca aatgctacca ttactggccc      900

atttctctga agaagccatt ggaattgaaa cacttccgtg tattcctgga gaactaccag      960

atacttcaat atttcatcat tcgaatgttt caagttgtgg agaagtccac gggaactagt     1020

cactctgtaa aacagttgca gttcaccaag tggccagacc atggcactcc tgcctcagca     1080

gatagcttca taaaatatat tcgttatgca aggaagagcc accttacagg acccatggtt     1140

gttcactgca gtgccggcat aggccggaca ggggtgttcc tatgtgtgga tgtcgtgttc     1200

tgtgccatcg taaagaactg ttcattcaac atcatggata tagtggccca aatgagagaa     1260

caacgttctg gcatggttca aacgaaggag cagtatcact tttgttacga tattgtgctt     1320

gaagttcttc ggaaacttct gactttggat taagaaagac ttctgttgcc tctcacttga     1380

aattaccaag tgggtttgca c                                               1401


<210> 3913
<211> 788
<212> DNA
<213> Homo sapiens

<400> 3913
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct      540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaaca gataccgaga      600

tattcttcca tttcaacatc atggatatag tggcccaaat gagagaacaa cgttctggca      660

tggttcaaac gaaggagcag tatcactttt gttacgatat tgtgcttgaa gttcttcgga      720

aacttctgac tttggattaa gaaagacttc tgttgcctct cacttgaaat taccaagtgg      780

gtttgcac                                                               788


<210> 3914
<211> 693
<212> DNA
<213> Homo sapiens

<400> 3914
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg aatttcccac      120

ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat cccagcatgt      180

ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag gaggctgcag      240

ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt tctgaaggag      300

aactagatca gttggctcag attcggccat taatattcaa ttttcatgag cagacagcca      360

tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc atgcaggaat      420

ttatggcttt agaacttaag aatctgcctg gtgagttcaa ctctgggaat caaccaagca      480

acagagaaaa aaacagatac cgagatattc ttccatttca acatcatgga tatagtggcc      540

caaatgagag aacaacgttc tggcatggtt caaacgaagg agcagtatca cttttgttac      600

gatattgtgc ttgaagttct tcggaaactt ctgactttgg attaagaaag acttctgttg      660

cctctcactt gaaattacca agtgggtttg cac                                   693


<210> 3915
<211> 457
<212> DNA
<213> Homo sapiens

<400> 3915
aggtggcata ttggtttttc tggaatccgt tgcgaaactg ttcttatcta cttaaaggga       60

actcatttga agtctgagtc ttgagggaat aggcagaaca ggcatgttgg aaggaaagta      120

tgagtctcag gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc      180

ctgactcaca ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg      240

ggatgggaac aacatgtctt cacctaggga ctttagagca gagcctgtaa acgattatga      300

gggaaatgac tctgaagcag aagacttgaa tttcagggag actttgcctt catcaagtca      360

ggaaaacaca cctagatcaa aggtttttga aaataaagtt aattcagaga aggtaaaact      420

ttctcttcgg aatttcccac ataatgatta tgaggat                               457


<210> 3916
<211> 676
<212> DNA
<213> Homo sapiens

<400> 3916
aatacaatta gagaaccata aagggcaaac atattaaaag agcttaattt tgtagtgtgg       60

cctgcaggct tccagaaaaa aacaggagat cagtgagcta gcagcagaga agccttcctg      120

gaaaaggatg gaaaggcaga tgtaaagtcc ctcatggcga aatataacac ggggggcaac      180

ccgacagagg atgtctcagt caatagccga cccttcagag tcacagggcc aaactcatct      240

tcaggaatac aagcaagaaa gaacttattc aacaaccaag gaaatgccag ccctcctgca      300

ggacccagca atgtacctaa gtttgggtcc ccaaagccac ctgtggcagt caaaccttct      360

tctgaggaaa agcctgacaa ggaacccaag cccccgtttc taaagcccac tggagcaggc      420

caaagattcg gaacaccagc cagcttgacc accagagacc ccgaggcgaa agtgggattt      480

ctgaaacctg taggccccaa gcccatcaac ttgcccaaag aagattccaa acctacattt      540

ccctggcctc ctggaaacaa gccatctctt cacagtgtaa accaagacca tgacttaaag      600

ccactaggcc cgaaatctgg gcctactcct ccaacctcag aaaatgaaca gaagcaagcg      660

tttcccaaat tgactg                                                      676


<210> 3917
<211> 567
<212> DNA
<213> Homo sapiens

<400> 3917
ggccgggcgt ccccgcggcg ctcctcgtgg ggcggggcgc aggcggggcg gggccccctc       60

tccagccgcc cgccctccgg ccgcgtcccc gccggccctg cagacgtggc ggggcgggac      120

ccgctgggca ctcccgcgcg tactcggccg cctgagcgat actaaaatgt ctgatgatgc      180

tggtgacacc ttagccactg gagacaaagc agaagttact gagatgccta atagtgattc      240

tttacctgag gatgcagaag tgcattgtga ttcagctgca gtttcacatg agccaacacc      300

agctgacccc agaggggagg ggcatgaaaa tgcagctgtg cagggtgcag gggctgccgc      360

cattgggccc cctgtgcagc ctcaggatgc caacgccctg gagccccctc tcaatggaga      420

cgtgactgag gatacacttg ctgaatgtat tgattccgtc agccttgagg cagaacccag      480

atccgaaata cccctgcaag aacagaatta tctggctgtg gattcccctc caagtggagg      540

aggatgggca ggctggggat cctgggg                                          567


<210> 3918
<211> 564
<212> DNA
<213> Homo sapiens

<400> 3918
gctcaaagtg gcggagcgcg gcggcgggag gcaggtgcac ggcacccgcc agtgggggtg       60

cctcaacttc cgcgggcgtt taaatagcag cctctctccc ctcccaccgg ctgcctgctg      120

tttcccgggg agatcatgaa acgaggtcgc cttcccagca gcagtgagga ttctgacgac      180

aatggcagcc tgtcaactac ttggtcccag aattcccgat cccagcatag gagaagctcc      240

tgctccagac atgaagatcg aaagccttca gaggtgttta ggacagacct gatcactgcc      300

atgaagttgc atgactccta ccagctgaat ccggatgagt actatgtgtt ggcagatccc      360

tggagacagg aatgggagaa aggggtccag gtgcctgtga gcccggggac catccctcag      420

cctgtggcca gggttgtgtc tgaagagaaa tccctcatgt tcatcaggcc caagaagtac      480

atcgtgtcat caggctctga gcctcccgag ttgggctatg tggacatccg gacgctggct      540

gacagcgtgt gtcgctatga cctc                                             564


<210> 3919
<211> 1524
<212> DNA
<213> Homo sapiens

<400> 3919
aacattcagt acaatctgct gcccaggacc tggacattga cagataaaat gaagaagaat       60

atgaagaact gcttcattat gctatagtga ctccaaatat tgaaccctgt gcttcacagt      120

catctcatcc taagggagaa ttggtgccag atgtcagaat ttctacaatt catgatattc      180

ttcatagtca aggaaataac tctgaagtaa gagaaactgc aatagaagtt ggaaaaggat      240

gtgatttcca tatttcaagt cattcaaaga cagatgagtc atcaccagtg ttatcgccaa      300

ggaagccttc tcacccagtc atggattttt tcagttcaca tcttttagct gactcttcct      360

caccagcaac aaattctagt catacagatg cccatgaaat acttgtgagc gattttcttg      420

tttctgatga aaaccttcag aagatggaaa atgtgcttga tctttggagt tcaggtctta      480

agacaaacat catatctgaa ctaagtaaat ggagacttaa ttttattgac tggcaccgaa      540

tggaaatgag aaaagagaaa gaaaaacatg cagcacattt aaaacaactg tgtaatcaga      600

tcaatgaatt gaaggagctg caaaaaacct ttgaaatctc cattgggaga aaagatgagg      660

tgatttctag cttgtctcat gccataggca agcaaaagga aaagatagag ttgatgagaa      720

cattcttcca ctggcgaatc ggccatgtca gagccagaca ggatgtttat gaaggtaaac      780

tagctgacca gtactaccag agaactttac tgaagaaagt ctggaaagtc tggcgttccg      840

tagtgcaaaa gcagtggaaa gatgtggtag aaagagcttg tcaagcaaga gctgaagaag      900

tttgtatcca gatttccaat gattatgaag ccaaagttgc tatgttatct ggagctttgg      960

aaaatgcaaa agctgagatt caaagaatgc aacatgaaaa agagcacttt gaagattcca     1020

tgaaaaaagc tttcatgagg ggtgtatgtg cattaaatct tgaagccatg actatatttc     1080

aaaacagaaa tgatgcaggg atagactcca caaataataa aaaggaagag tatggtcctg     1140

gtgttcaagg aaaagaacat tctgctcatt tggatccttc agctcctccg atgcccttac     1200

cagttacatc accactgctg ccatccccac cagccgccgt cggaggagcc agcgcgactg     1260

ccgttccctc agctgcttcg atgacttcta ccagggctgc ttccgcatct tctgttcacg     1320

ttcctgtttc tgctcttggt gcaggatctg cagctactgc tgcatcagaa gaaatgcaaa     1380

ccattcctca agcaactgca gcaaaatatc cccggaccat tcatcctgaa agtagtacct     1440

cagcttccag atcacttgga accagatcag ctcacaccca gtctctcaca agtgttcatt     1500

ccataaaagt ggttgactaa agtg                                            1524


<210> 3920
<211> 591
<212> DNA
<213> Homo sapiens

<400> 3920
cagagtttat caactactgc cctgaagggc gcttttctgt tttagctgct ttcaagcaaa       60

tctgtgtctt ttagaattgt caaccttcag ctctttttgg ttgggcaaaa ttaaacagtt      120

ctatttttaa taacagcgaa gaaacatatg tatttaatat tgggatcatt taccacgagc      180

gattacatga ggcatggttt cttaaacgct aaagtggctt aaaaaaggga atttagttgg      240

atataaaagt aaatttcaga gcaaagtctg aaatggatgt tacatgagtc attttaaggg      300

atgcacacaa ctatgaacat ttctgaagat tttttctcag taaagtagat aaagatggat      360

gaatcagcct tgttggatct tttggagtgt ccggtgtgtc tagagcgcct tgatgcttct      420

gcgaaggtct tgccttgcca gcatacgttt tgcaagcgat gtttgctggg gatcgtaggt      480

tctcgaaatg aactcagatg tcccgagtgc aggactcttg ttggctcggg tgtcgaggag      540

cttcccagta acatcttgct ggtcagactt ctggatggca tcaaacagag g               591


<210> 3921
<211> 854
<212> DNA
<213> Homo sapiens

<400> 3921
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtgaacaa aaattgtttg ctggccccca ggatactaac tagacctttg gcctgactca      120

caggacacta aggctccttt tctgaagaag ccttttacca gtctcattta ggggatggga      180

acaacatgtc ttcacctagg gactttagag cagagcctgt aaacgattat gagggaaatg      240

actctgaagc agaagacttg aatttcaggg agactttgcc ttcatcaagt caggaaaaca      300

cacctagatc aaaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc      360

ggaatttccc acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg      420

atcccagcat gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg      480

aggaggctgc agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg      540

tttctgaagg agaactagat cagttggctc agattcggcc attaatattc aattttcatg      600

agcagacagc catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata      660

tcatgcagga atttatgttc aacatcatgg atatagtggc ccaaatgaga gaacaacgtt      720

ctggcatggt tcaaacgaag gagcagtatc acttttgtta cgatattgtg cttgaagttc      780

ttcggaaact tctgactttg gattaagaaa gacttctgtt gcctctcact tgaaattacc      840

aagtgggttt gcac                                                        854


<210> 3922
<211> 578
<212> DNA
<213> Homo sapiens

<400> 3922
agatgattcc ctgattctcc agagagatta cacacttcgt ttgtggctaa ggttactgtg       60

acccaatgaa agaagaaaat gaaagccata aagaaaagtc ttacagaaga agaatacctg      120

tacctggact tttctcacca aacagaagga tgcatctttc ctcttcatac atctgtaact      180

ttatttctgt tatcttactg tgactgtaaa atctttaaaa tttgcttagt tgtcaccaaa      240

gaggtgagta gagatagttc actactaaga gatgacctga tccaggatgt tgaaatacag      300

attatttcaa ggcaggagct cccaccaata gtccaaaatt gctgtttgcc tgcagtagta      360

gaacgatcag acaatttttg tagagcagga cttgctgttg tattgagaca cataatccag      420

aaatcctatg aagcagaccc cttaaagaag gaacttttgg aacttctggg ctttaaaaag      480

acttgcttga aagcctgtgc tgaagttagt cagtggacca ggctatgtga actcaccatc      540

cctttggcta ttgagaattt tctcagagaa tcttctga                              578


<210> 3923
<211> 782
<212> DNA
<213> Homo sapiens

<400> 3923
gctttgtgta actgggcaga gctaacacct gagctgttaa agatcctgca ttctcagcat       60

gctcttcact aggatttgca aaggtaactg ccacacagag ccatctttac cttcctaaca      120

ccccctcccg ccccttgcca tgtgctggga gatgtggacc tggcctgggg acagggtgtt      180

tctcagggcc ttgtctcaac ttctcccaca acctctgtgt tgtgtctgtc ccctgccctg      240

caggttgctg gcagactgat catccgtgca gaggagctgg cccagatgtg gaaagtggtg      300

aatctcccaa cagatctgtt taatagtgtg atgaatgtgg gtcgcttcac ggaggagatc      360

gagtggctga agtttttagc ccttgcttgc agcgctctgg gagttactat taccaaaact      420

ctcaagatag tgtgtgaggt cttatcatgt gaccacaatg gtgggttgcc ccgaatccca      480

ttcagcacct tccagtttct ctacacgtat attgccgaag tggatgggga gatctgtgca      540

tcacatgtca gcaggatgct aaactacatt gaacaggaag taattggtcc tgatggttta      600

atcacggtga atgactttac ccaaaacccc agggtttggc tggagtaaca gcacaatttt      660

ggcaatttta aaggaagata cagaggtgat tgtacttcag aatgataaac ccatatacca      720

cctaaaatca attttcttgt acaactggta cacactaata aacaaacatg tgagatcaga      780

aa                                                                     782


<210> 3924
<211> 577
<212> DNA
<213> Homo sapiens

<400> 3924
aaaagaggtt gtgtcgacgg aggcagaagc gacgcagatg cgaaagtggc ggcctccggg       60

caccatttct gtgcacggaa acagaatccg ggtttgaagg cagccgccgc ttcgcttacc      120

cagtacctag tgttccgtcg tgtttgacca acccccctct ccctgccacc gcgggtttaa      180

tccgaacgtg ttcggatact ggaactcatt tgacattgtg cagcaaagaa atggttatgg      240

agaagcccag tccgctgctt gtagggcggg agtttgtgag gcaatattat actttgctga      300

ataaagctcc ggaatattta cacaggtttt atggcaggaa ttcttcctat gttcatggtg      360

gagtagatgc tagtggaaag ccccaggaag ctgtttatgg ccaaaatgat atacaccaca      420

aagtattatc tctgaacttc agtgaatgtc atactaaaat tcgtcatgtg gatgctcatg      480

caaccttgag tgatggagta gttgtccagg tcatgggttt gctgtctaac agtggacaac      540

cagaaagaaa gtttatgcaa acctttgttc tggctcc                               577


<210> 3925
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 3925
ttcaggaatg tctgatcaca gatacgggga tggtggctct actttccaga gcacaacagg       60

acactgtgta cacatgcggg gattacctta cagagctact gagaatgaca tttataattt      120

tttttcaccg ctcaaccctg tgagagtaca cattgaaatt ggtcctgatg gcagagtaac      180

tggtgaagca gatgtcgagt tcgcaactca tgaagatgct gtggcagcta tgtcaaaaga      240

caaagcaaat atgcaacaca gatatgtaga actcttcttg aattctacag caggagcaag      300

cggtggtgct tacggtagcc aaatgctagg aggcatgggt ttgtcaaacc agtccagcta      360

cgggggccca gccagccagc agctgagtgg gggttacgga ggcggctacg gtggccagag      420

cagcatgagt ggatacgacc aagttttaca ggaaaactcc agtgattttc aatcaaacat      480

tgcataggta accaaggagc agtgaacagc agctactaca gtagtggaag ccgtgcatct      540

atgggcgtga acggaatggg agggttgtct agcatgtcca gtatgagtgg tggatgggga      600

atgtaattga tcgatcctga tcactgactc ttggtcaacc tttttttttt tttttttttt      660

ttctttaaga aaacttcagt ttaacagttt ctgcaataca agcttgtgat ttatgcttac      720

tctaagtgga aatcaggatt gttatgaaga cttaaggccc agtatttttg aatacaatac      780

tcatctagga tgtaacagtg aagctgagta aactataact gttaaactta agttccagct      840

tttctcaagt tagttatagg atgtacttaa gcagtaagcg tatttaggta aaagcagttg      900

aattatgtta aatgttgccc tttgccacgt taaattgaac actgttttgg atgcatgttg      960

aaagacatgc ttttattttt ttgtaaaaca atataggagc tgtgtctact attaaaagtg     1020

aaacattttg gcatgtttgt taattctagt ttcatttaat aacctgtaag gcacgtaagt     1080

ttaagctttt ttttttttta agttaatggg aaaaatttga gacgcaatac caat           1134


<210> 3926
<211> 545
<212> DNA
<213> Homo sapiens

<400> 3926
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgtt caacatcatg gatatagtgg cccaaatgag agaacaacgt tctggcatgg      420

ttcaaacgaa ggagcagtat cacttttgtt acgatattgt gcttgaagtt cttcggaaac      480

ttctgacttt ggattaagaa agacttctgt tgcctctcac ttgaaattac caagtgggtt      540

tgcac                                                                  545


<210> 3927
<211> 685
<212> DNA
<213> Homo sapiens

<400> 3927
aaaagtgtag caacaactga gtttgctgtc tcactaccct cagcctaggc caacctggac       60

tccttcaccc caaatgaggt gaccgctaca ttttatatga agacactgat ttaccattca      120

actgtgatcc atcttataac atggcaatcc aatacagaca ggaagataaa actcaacaac      180

agctaaaata aagtgtattc ccagaataca cattgcagaa aaaggatgaa gttgaccagt      240

gaaaagttgc ccaagaaccc cttttatgcc tctgtatctc agtatgctgc taaaaaccaa      300

aaatttttcc agtggaaaaa ggaaaagact gattacaccc atgctaattt ggtggataag      360

gcattgcagc tcttgaagga aagaatactg aaaggagaca ctctggcata tttcctacga      420

ggtcaactat attttgaaga gggatggtat gaagaagcat tagaacagtt tgaagaaatc      480

aaggagaaag accatcaagc aacttaccag ctaggagtga tgtactatga tgggctgggg      540

accactctag acgctgagaa aggggtggac tatatgaaga aaattcttga ttctccatgt      600

cccaaagcaa gacacttaaa atttgcagct gcttacaacc tcggaagagc ttattatgaa      660

ggaaaaggtg ttaaacgatc aaatg                                            685


<210> 3928
<211> 629
<212> DNA
<213> Homo sapiens

<400> 3928
gatgtgggtg agttcatttg ctcgcgtgca ggggaagtct ggagaaggca ttgtttcaat       60

tattaaaagt gtgggggcag tgggcggaac aaacgcgccg actacagagg ctggacttgc      120

caaaacaaag gggatttggt gatggaggct ttgttagaag gaatacaaaa tcgagggcat      180

ggtgggggat ttttgacatc ttgtgaagca gaactacagg agctcatgaa acagattgac      240

ataatggtgg ctcataaaaa atctgaatgg gaaggacgta cacatgctct agaaacttgc      300

ttgaaaatcc gtgaacagga acttaagagt cttaggagtc agttggatgt gacacataag      360

gaggttggaa tgttgcatca gcaggtagaa gaacatgaaa aaatcaagca agagatgacc      420

atggaatata agcaggagtt gaagaaacta catgaagaat tatgcatact gaagagaagc      480

tatgaaaagc ttcagaaaaa gcaaatgagg gaattcagag gaaataccaa aaatcacagg      540

gaagatcggt ctgaaattga gaggttaact gcaaaaatag aggaattccg tcagaaatcg      600

ctggactggg agaagcaacg cttgattta                                        629


<210> 3929
<211> 3560
<212> DNA
<213> Homo sapiens

<400> 3929
cataacaagc caaacgccag accgagagtg cctccgtgcg cgagtgcccg gtgtgtgcgc       60

gccggcgaga gcaggggccc gcccggctcc ccgcccgccg cggcccgaac tcatgcagct      120

ccgagcgagc gagcggcgcc cagcccagcg cctcggccga acccctccgc agcaggctgc      180

ctgctgtttc ccggggagat catgaaacga ggtcgccttc ccagcagcag tgaggattct      240

gacgacaatg gcagcctgtc aactacttgg tcccagaatt cccgatccca gcataggaga      300

agctcctgct ccagacatga agatcgaaag ccttcagagg tgtttaggac agacctgatc      360

actgccatga agttgcatga ctcctaccag ctgaatccgg atgagtacta tgtgttggca      420

gatccctgga gacaggaatg ggagaaaggg gtccaggtgc ctgtgagccc ggggaccatc      480

cctcagcctg tggccagggt tgtgtctgaa gagaaatccc tcatgttcat caggcccaag      540

aagtacatcg tgtcatcagg ctctgagcct cccgagttgg gctatgtgga catccggacg      600

ctggctgaca gcgtgtgtcg ctatgacctc aatgacatgg atgctgcatg gctggaactg      660

accaatgaag aatttaagga gatgggaatg cctgaactag atgaatacac catggagagg      720

gtcctagagg aatttgagca gcgatgctac gacaatatga atcatgccat agagactgag      780

gaaggcctgg ggatcgaata tgatgaagat gttgtctgtg atgtctgcca gtctcctgat      840

ggtgaggacg gcaatgagat ggtgttctgt gacaaatgca acatctgtgt gcaccaggcc      900

tgttatggaa tcctcaaggt accagagggc agctggctgt gccggacatg tgccctgggg      960

gttcagccaa aatgtctgct gtgtccgaag aagggtggag ctatgaagcc cacccgtagc     1020

ggaaccaagt gggtccacgt tagctgtgct ctgtggatcc ctgaggtgag cattggcagc     1080

ccagagaaga tggagcccat caccaaggtg tcacacattc ccagcagccg gtgggcgcta     1140

gtgtgcagcc tctgcaatga gaagtttggg gcctctatac agtgctctgt gaagaactgc     1200

cgcacagcct tccatgtgac ctgtgctttt gaccggggcc tggagatgaa gaccatctta     1260

gcagagaatg atgaagtcaa gttcaagtcc tattgcccaa agcacagctc acataggaaa     1320

cccgaggaga gtcttggcaa gggggctgca caggagaatg gggcccctga gtgttccccc     1380

cggaatccgc tggagccctt tgccagcctt gagcagaacc gggaggaggc ccaccgggtg     1440

agtgtccgta agcagaagct gcagcagttg gaggatgagt tctacacctt cgtcaacctg     1500

ctggatgttg ccagggctct gcggctgcct gaggaagtag tggatttcct gtaccagtac     1560

tggaagttga agaggaaggt caacttcaac aagcccctga tcaccccaaa gaaagatgaa     1620

gaggacaatc tagccaagcg ggagcaggat gtcttattta ggaggctgca gctgttcacg     1680

cacctgcggc aggacctgga gagggtaatg attgacactg acaccttata gtgacttaga     1740

gaagaagatg caaagaggcg aacgctcgcc cagagcaaga aatgatagcc agtcatatac     1800

tctcagaccc ttgtacacac cacagcatga ggttgtgttg gttaaaaata tttatgggct     1860

ggtaaactca ttgtacatat gtgcaaaact gctactgagt ggggagcttc tttgtggttt     1920

tttttttttt aaaaacactt tcccattaat ctttactgtt ttgtaagatc aaatggggtg     1980

tgtcttcccc acccccattc cttcattcta gagctagagt gaatgagccc caagaaaatg     2040

acccaaggag ttgactcagg atggtttaca gactgattta gaaaaccaga acggatttca     2100

tttctaatgg agggggccag agatgggaaa atttcttgtt cagtccgggg aaacacacct     2160

aggtgctggt gatgggctta tgaaggaagc taagcacggc tgctcactgg cccccacttt     2220

gtttcttggg taattcacag gggaattccc agtactgtca tggagcagag caggcagtgg     2280

gtgctgatgt gtgtgcatga gctgtatgta cacatgcata tatctgttac agaagatact     2340

cctggcagtg aggtgctaag tcatcactga ggctgtgtgt gtgtgtgtgt gtgcgcgtgc     2400

ccgtgtccat ccatgtctct gttgtgtgtc tgtgtgcggg tatgggtggg attcctggtg     2460

gacaggggtg tcagatctgt ctgaggagcc ccagtcatgc tcagcacgct acagatgtgt     2520

tgtttgtcac actgagattg ctgaatgtcg tggctgttgg ctgccgagcc tcagctgctg     2580

gcatttcctt ctgctgtttg ctgcttttgt gcctccccca ctttccatca cctctggagt     2640

cccgtctgga cgtcccttcc tgctacagga ataatgaggc gtgggctgcc tcccgctagg     2700

gcctcctgct ccctgtaggt agtttctggc tgaggcttgc taattgggga tgcttcttag     2760

agcatcttcc acatcaactc ccctggctgc tggctaccga ttaaattcat tagtgtgaaa     2820

gaggtgggag tgaggttttc tggcctgaag cagtctgcac tgaaaggtac ccaagtggcc     2880

tgaaacagtg tagggaaaga cctgggaaac actggaccaa aaaagcctga tctcatggag     2940

acctgcatgg ccctgttaga gatggcgtag aagtgaaagt cttaaaggga gcattagaga     3000

tccttttaat acacgactga gtgccagctt atttgtgatg ccccttccca gaccaggtta     3060

ggattcctgg gaaggccgcg gattccggcc ctggaagagg caggatcctg gagcagtttt     3120

gtgaggcttt tgtgctccca tacgccccct ggtggtgagt gtaaagaaga ctttgcctct     3180

cacaactaca tgtatgtgtg gcatttttgt tagagatgag aaaaggattg agaaggataa     3240

actggaatcc tggtaagaag cctttatgcc agcccgacac ctgctgtaat tggggtgcat     3300

gagctatgga gtcagatagt tgttgggagg gggaggacaa gaagtctatt gtttggactg     3360

tgtttgtctc acaatcacca caaaataaaa gtgtagaaaa tgcttgtggt gtactaactc     3420

ttttctgtac ttaagttact cagattaaca tgcacttcta attctaaaca ttttttttgg     3480

agtcatcact gtcgctgttt aagtagaaca atgccaacga tgtatgagaa acagggaata     3540

aatcaggatt tgtgtgtgta                                                 3560


<210> 3930
<211> 441
<212> DNA
<213> Homo sapiens

<400> 3930
agtgcctccg ggtcgcggtc attttgagcc cctgtctgga tgacttcttg cggctgttct       60

acccctcccc ctccccgcgt cgcctgctgc tgtcgtcggg aggtgggtga ggtgacgcaa      120

acagccccgt tgttgccctc cgcgtatccc ctcaccacct ttgcggccat ccacgacttt      180

cgcaccttcc gccattttcc tgcctgtgag ggtggacaga tcgcgctcgg gtctcggcct      240

cctgagtgcc ggtgactgcg ggaggcgacg gagtgcttct gggggtgtga gctggggaag      300

ttcgtggtca cggatgcgtg tggggttgct gctcagtctg taacggcagg aaagatgaat      360

gggagggctg attttcgaga gccgaatgca gaggttccaa gaccaattcc ccacataggg      420

cctgattaca ttccaacaga g                                                441


<210> 3931
<211> 1339
<212> DNA
<213> Homo sapiens

<400> 3931
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct      540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaaca gataccgaga      600

tattcttcca tatgattcaa cacgcgttcc tcttggaaaa agcaaggact acatcaatgc      660

tagttatatt agaatagtca attgtggaga agagtatttt tatatcgcta ctcaaggacc      720

actgctgagc accatagatg acttttggca aatggtgttg gaaaataatt caaatgttat      780

tgccatgata accagagaga tagaaggtgg aattatcaaa tgctaccatt actggcccat      840

ttctctgaag aagccattgg aattgaaaca cttccgtgta ttcctggaga actaccagat      900

acttcaatat ttcatcattc gaatgtttca agttgtggag aagtccacgg gaactagtca      960

ctctgtaaaa cagttgcagt tcaccaagtg gccagaccat ggcactcctg cctcagcaga     1020

tagcttcata aaatatattc gttatgcaag gaagagccac cttacaggac ccatggttgt     1080

tcactgcagt gccggcatag gccggacagg ggtgttccta tgtgtggatg tcgtgttctg     1140

tgccatcgta aagaactgtt cattcaacat catggatata gtggcccaaa tgagagaaca     1200

acgttctggc atggttcaaa cgaaggagca gtatcacttt tgttacgata ttgtgcttga     1260

agttcttcgg aaacttctga ctttggatta agaaagactt ctgttgcctc tcacttgaaa     1320

ttaccaagtg ggtttgcac                                                  1339


<210> 3932
<211> 573
<212> DNA
<213> Homo sapiens

<400> 3932
ctgcgcagac cccgcctccc accgcagggg cacgcctcct acccccaccc ttcgcggatt       60

gatcctgctg gccgcagcca cccacgtggt ggaagcccgg ccctgcaggc tggagaggat      120

ttgattagac tacgcgtttc gacttgcagg gtgtttaatc gtcgccaagc gggacttact      180

gcaagctatc aaatctgagg tcttattttg ttgagtcgaa agtgaaattt tcctttggcc      240

aacgtgacag catttgacat tgtgcagcaa agaaatggtt atggagaagc ccagtccgct      300

gcttgtaggg cgggagtttg tgaggcaata ttatactttg ctgaataaag ctccggaata      360

tttacacagg ttttatggca ggaattcttc ctatgttcat ggtggagtag atgctagtgg      420

aaagccccag gaagctgttt atggccaaaa tgatatacac cacaaagtat tatctctgaa      480

cttcagtgaa tgtcatacta aaattcgtca tgtggatgct catgcaacct tgagtgatgg      540

agtagttgtc caggtcatgg gtttgctgtc taa                                   573


<210> 3933
<211> 859
<212> DNA
<213> Homo sapiens

<400> 3933
atgaaaggat ggggacctca ccagagagga ctggtctcag caatgtcctt aagtggtcaa       60

aacatgctgc ggttgagtct ccacccacat ttgcacaaag gaccatcacc tgtccttcct      120

ggaatctcta aagttttctg ctttccttct gtcctgatgg ccagctctgc taagtcagct      180

gagatgccca ccatctccaa aaccgttaac cctactcctg atcctcatca agaatatctg      240

gaccctagga ttaccattgc cttattcgaa attggatcac attccccttc ctcctggggc      300

tctctccctt tcctaaagaa tagcagccat caagttacag aacaacagac tgcacagaag      360

tttaacaatc tcttaaaaga aattaaagat attcttaaaa atatggcagg ttttgaagag      420

aagatcacag aagcaaaaga actttttgag gaaaccaata ttactgagga tgtgtcagcc      480

cacaaagaaa atatcagagg acttgacaaa atcaatgaaa tgttatcaac aaacctgcct      540

gttagtttag ccccagagaa agaagacaat gaaaagaaac aggagatgat attggaaacc      600

aatattactg aggatgtgtc agcccacaaa gaaaatatca gaggacttga caaaatcaat      660

gaaatgttat caacaaacct gcctgttagt ttagccccag agaaagaaga caatgaaaag      720

aaacagcaga tgataatgga aaaccagaac tctgagaaca ccgcacaagt ttttgcaaga      780

gatttggtaa atcgtttaga agaaaaaaaa gtccttaacg aaactcaaca aagtcaggaa      840

aaagcaaaaa acagactta                                                   859


<210> 3934
<211> 3692
<212> DNA
<213> Homo sapiens

<400> 3934
agcacttgaa gttcaggcag cgagagttga catggggcca gggctgcgcc cctggggcgg       60

gttgaagaca gggtgagtct cttgatattc aggaaatcat cgcgcaccca gtcaccagcg      120

ttcgggagcc tgtcgcagcg ggaccgacgg aatccggagc aggcgacagg gcgcagaagc      180

gggatgtact tctgttgggg cgccgactcc agggagctgc agcgccggag gacggcgggc      240

agccccgggg ctgagctact gcaggcggcc agcggggagc gccactctct gctgctgctg      300

accaaccaca gggtcctctc gtgcggagac aacagcaggg gtcagctggg ccgcaggggc      360

gcgcagcgcg gggagctgcc agaaccaatt caggcattgg aaaccctaat tgttgatctc      420

gtgagctgcg ggaaggagca ctccctggct gtgtgccaca aaggaagggt cttcgcatgg      480

ggagctggtt ctgaagggca gctggggatt ggagaattca aggaaataag tttcacacct      540

aagaaaataa tgactctgaa tgatataaaa ataatacaag tttcctgtgg acactaccac      600

tccctggcat tatcaaaaga tagccaagtg ttttcgtggg gaaagaacag ccatgggcag      660

ctgggcttgg ggaaggagtt cccctcccaa gccagcccgc agagggtgag gtccctggag      720

gggatcccac tggctcaggt ggctgccgga ggggctcaca gctttgccct gtctctctgt      780

gggacttcgt ttggctgggg aagtaacagt gccgggcagc tggccctcag tgggcgtaat      840

gtcccagtgc aaagcaacaa gcctctctca gtcggtgcac tgaagaatct aggtgtggtt      900

tatatcagct gtggtgatgc acacactgcg gtgcttaccc aggacgggaa agtgttcaca      960

tttggagaca atcgctctgg acagctggga tacagcccca ctcctgagaa gagaggtcca     1020

caacttgtgg aaagaattga tggcctagtt tcgcagatag attgtggaag ttatcacacc     1080

ctggcatatg tgcacaccac tggtcaggtg gtatcttttg gtcatggacc aagtgacaca     1140

agcaagccaa ctcatccgga ggccctgaca gagaactttg acattagctg cctgatttct     1200

gctgaagact tcgtggatgt tcaagtcaaa cacatttttg ctggaacata tgccaacttt     1260

gtgacaactc atcagtgaaa ttagaatgat attttcatct cctgcttgtc tgactgcaag     1320

ttttttaaag aaaagaggaa ctggagaaac gacttccatt gatgtggact tagaaatggc     1380

aagagatacc ttcaagaagt taacaaaaaa ggaatggatt tcttccatga taactacgtg     1440

tctcgaggat gatctgctca gagctcttcc atgccattct ccacaccaag aagctttatc     1500

agttttcctc ctgctcccag aatgtcctgt gatgcatgat tctaagaact ggaagaacct     1560

ggtggttcca tttgcaaagg ctgtgtgtga aatgagtaaa caatctttgc aagtcctaat     1620

aaacaaagct aactgtcgac taccagaaaa tactttcaac ataaatgaac tctccaactt     1680

attaaacttt tatatagata gaggaagaca gctctttcgg gataaccacc tgatacctgc     1740

agaaaccccc agtcctgtta ttttcagtga ttttccattt atctttaatt cgctatccaa     1800

aattaaatta ttgcaagctg attcacatat aaagatgcag gctggagtac aatggtgcaa     1860

tctcagctca ccacaacctc tgcctcccgg gttcaagcga ttcttctgcc tcagcctccc     1920

aaatgtcaga aaagaaagca tacatgctta tgcatgaaac aattctgcaa aaaaaggatg     1980

aatttcctcc atcacccaga tttatactta gagtcagacg aagtcgcctg gttaaagatg     2040

ctctgcgtca attaagtcaa gctgaagcta ctgacttctg caaagtatta gtggttgaat     2100

ttattaatga aatttgtcct gagtctggag gggttagttc agagttcttc cactgtatgt     2160

ttgaagagat gaccaagcca gaatatggaa tgttcatgta tcctgaaatg ggttcctgca     2220

tgtggtttcc tgccaagcct aaacctgaga agaaaagata tttcctcttt ggaatgctgt     2280

gtggactctc cttattcaat ttaaatgttg ctaaccttcc tttcccactg gctctgtata     2340

aaaaacttct ggaccaaaag ccatcattgg aagatttaaa agaactcagt cctcggttgg     2400

ggaagagttt gcaagaagtt ctagatgatg ctgctgatga cattggagat gcgctctgca     2460

tacgcttttc tatacactgg gaccaaaatg atgttgactt aattccaaat gggatctcca     2520

tacctgtgga ccaaaccaac aagagagact atgtttctaa gtatattgat tacattttca     2580

acgtctctgt aaaagcagtt tatgaggaat ttcagagagg attttataga gtctgtgaga     2640

aggagatact tagacatttc taccctgaag aactaatgac agcaatcatt ggaaatactg     2700

attatgactg gaaacagttt gaacagaatt caaagtatga gcaaggatac caaaaatcac     2760

atcctactat acagttgttt tggaaggctt tccacaaact aaccttggat gaaaagaaaa     2820

aattcctctt tttccttaca ggacgtgata ggctgcatgc aagaggcata cagaaaatgg     2880

aaatagtatt tcgctgtcct gaaactttca gtgaaagaga tcacccaaca tcaataactt     2940

gtcataatat tctctccctc cctaagtatt ctacaatgga aagaatggag gaagcacttc     3000

aagtagccat caacaacaac agaggatttg tctcacccat gctcacacag tcataatcac     3060

ctctgagaga ctcagggtgg gctttctcac acttggatcc ttctgttctt ccttacacct     3120

aaataataca agagattaat gaatagtggt tagaagtagt tgagggagag attgggggaa     3180

tggggagatg atgatgatgg tcaaagggtg caaaatctca cacaagactg aggcaggaga     3240

atagggtaca gagataggga tctaaggatg acttggacac actccctggc actgaagagt     3300

ctgaacactg gcctgtgatt ggtccattcc aggaccttca tttgcataag gtatcaaacc     3360

acatcagcct ctgattggcc atgggccaga cctgcactct ggccaatgat tggttcattc     3420

caggacattc atttgcataa ggagtcaaac cacaccagtc ttggattggc tgtgagccaa     3480

ttcacctcag tctctaattg gctgtgagtc agtctttcat ttacataggg tgtaaccatc     3540

aagaaacctc tacagggtac ttaagcccca gaagattttg ctaccagggc tcttgagcca     3600

cttgctctag cccactccca ccctgtggaa tgtactttca cttttgctgc ttcactgcct     3660

tgtgctccaa taaatccact ccttcaccac cc                                   3692


<210> 3935
<211> 583
<212> DNA
<213> Homo sapiens

<400> 3935
gcacattcac tatccaagct gcaccatctt cggggtcatt gtgtgccagg catatcaact       60

cttttcaata aaaatgtttt tctagccact tcccagcact cgcagcatga agctcacacc      120

agaagtttcc agagatcacc ccagaggtga taagatctcg cccgcccttc cgtcccagga      180

tagtgtgatt gcgggaccat ggaatttaca aggatggaaa ggcagatgta aagtccctca      240

tggcgaaata taacacgggg ggcaacccga cagaggatgt ctcagtcaat agccgaccct      300

tcagagtcac agggccaaac tcatcttcag gaatacaagc aagaaagaac ttattcaaca      360

accaaggaaa tgccagccct cctgcaggac ccagcaatgt acctaagttt gggtccccaa      420

agccacctgt ggcagtcaaa ccttcttctg aggaaaagcc tgacaaggaa cccaagcccc      480

cgtttctaaa gcccactgga gcaggccaaa gattcggaac accagccagc ttgaccacca      540

gagaccccga ggcgaaagtg ggatttctga aacctgtagg ccc                        583


<210> 3936
<211> 2569
<212> DNA
<213> Homo sapiens

<400> 3936
gccggaacaa aaatgcctca gtttggaggt cgcgctcact gcgacggcag gctttgagtg       60

tagcacttgg tagttcttcc tctgctctgc ttcccttcgg aggaaaattt caggctgaag      120

gtttagcggg tgccgcctct aaagagagca atcactacac ttatggctgg gattttgcgc      180

ttagtagttc aatggccccc aggcagacta cagactgtga caaaaggtgt ggagtctctt      240

atttgtacag attggattcg tcacaaattc accagatcaa gaattccaga aaaagtgttt      300

caggcctcac ctgaagatca tgaaaaatac ggtggggatc cacagaaccc tcataaactg      360

catattgtta ccagaataaa aagtacaaga agacgtccat attgggaaaa agatataata      420

aagatgcttg gattagaaaa agcacatacc cctcaagttc acaagaatat cccttcagtg      480

aatgcaaaat tgaaagtagt taagcatttg ataagaatca agcccttgaa gttgccacaa      540

ggacttccag cagaggagaa catgtctaac acgtgcctca aaagcactgg ggagttagta      600

gtgcagtggc atctgaaacc tgtggagcag aaagcacatg agtcctaatg ccccagcagc      660

ttccgattgg aaaatgcaaa ttgtttttat ttaaagatgg tgagaaagtg ttttcattaa      720

aatatgtttt caaaaccatt ttcaggccgg gcacggtggc tcacctgtaa tcccagcact      780

ttgggaggcc aaggcgggca gatcacctga ggtcaagagt tcgagaccag cctgaccaac      840

atggagaaac ccccatctct actgaaaata cagaattagc caggcatggt ggcacatgcc      900

tgtaacccag ctactcggga ggctgaagca ggagaatcac ttgaacccgg gaggcagagg      960

ttgcagtgag ctgagatggt gccactgtac tccagcctgg gtgataggat gagactccat     1020

ctcaggggaa aaaaaaaaat ttttttttca ctgactaaac ctgctgcagc tctcttttac     1080

tacagacttg gagattttag tttaatttgg tttaattctc tgtcctttcc ctttcactgt     1140

ttcactccaa aacatgtaag aatggcaatg tttgaacatc tgcgtttggg tctactgcca     1200

ccttagcaag cctcattaac cattttataa aaattgcgtt agtattgttg ttgttgtttt     1260

tgagacaggg tcttgctctg tcacccaagc tggaatacag tggcatgatt tcagttcact     1320

gcagcctcga cctcccaggc tcaagtgatc ctcccacctc agcctccaga gtagctagga     1380

ctacaggcag tgtgccacca catccagcta attttttaaa gttttttcat agagacaggg     1440

actcactatg ttgtccaagc tggtctcaaa ctcctgggtt caagccatcc tcccacctca     1500

gcctcccaaa atgctgggat tacaggcatg agccactgta cccagccaaa attgttttct     1560

tttttaagtg aattcaacaa tttctgtgag tggctctttg catgaacact gtgcaaggtg     1620

ttggagaaat ccaaagctga ccaaaacatg gtccccacct tttggagctt acagtctgtt     1680

ctggggaaca gagattcagc caaagtcaag aaacactgga tgccagctag attatctgtt     1740

ctgtgctttg gtgtctataa gtacatatgt ggatatgggt tcattttatc cctaaactta     1800

gtaccaaacc agcatttaat atctaattat aaatctaatt tggcctaaac tttattattg     1860

cacactgcct gaacaaaacc tatttgtctc tatgtaaatt ttttcctcat ggaacaaggg     1920

tgtgaaatga aaatatttta ggatttattc aaaaacagac tattctgttt tcagcttcag     1980

aattgttctt tgaatcctaa ggaacctctg tcaacagttg aggttgctgt tgaaaagaaa     2040

gaagaaggag gcggaaatct ctcagggaga attatttcct ttcttttcta ttttagatac     2100

ctggaggggt ggggagaagt aagaattgta agggaggttc agtagtgggg aattctgtga     2160

cagctgattg aagatgatga tgaagaacct ctgcattcta gttacccttt gcttcccttc     2220

acctcttgta aaatttggct tggcaacaat gacattgtca tgcttattgt cccaatatcc     2280

atcctgtcgt agatcttaat gtttttgatc gttgcgttaa agtggaagtg ccacccacag     2340

tgaaaccaga tcccattaat aaataagctt aaaggcaact gcagttttaa ttccatagtt     2400

attgaatatc cagtgtgtgt aaggcctgga ggggagccaa aggacactaa cttctaagag     2460

ctccgtctag ttggagagaa acctgtgtgc cacaacatac agtgtccttg cttatgtggg     2520

gtcgaagaca tctgtgaaaa taaaagcagc ctctgctaat ttagcgcca                 2569


<210> 3937
<211> 594
<212> DNA
<213> Homo sapiens

<400> 3937
gcctccgggt cgcggtcatt ttgagcccct gtctggatga cttcttgcgg ctgttctacc       60

cctccccctc cccgcggaaa gatgaatggg agggctgatt ttcgagagcc gaatgcagag      120

gttccaagac caattcccca catagggcct gattacattc caacagagga agaaaggaga      180

gtcttcgcag aatgcaatga tgaaagcttc tggttcagat ctgtgccttt ggctgcaaca      240

agtatgttga ttactcaagg attaattagt aaaggaatac tttcaagtca tcccaaatat      300

ggttccatcc ctaaacttat acttgcttgt atcatgggat actttgctgg aaaactttct      360

tatgtgaaaa cttgccaaga gaaattcaag aaacttgaaa attcccccct tggagaagct      420

ttacgatcag gacaagcacg acgatcttca ccacctgggc actattatca aaagtcaaaa      480

tatgactcaa gtgtgagtgg tcaatcatct tttgtgacat ccccagcagc agacaacata      540

gaaatgcttc ctcattatga gccaattcca ttcagttctt ctatgaatga atct            594


<210> 3938
<211> 599
<212> DNA
<213> Homo sapiens

<400> 3938
gacctttggc ctgactcaca ggacactaag gctccttttc tgaagaagcc ttttaccagt       60

ctcatttagg ggatgggaac aacatgtctt cacctaggga ctttagagca gagcctgtaa      120

acgattatga gggaaatgac tctgaagcag aagacttgaa tttcagggag actttgcctt      180

catcaagtca ggaaaacaca cctagatcaa aggtttttga aaataaagtt aattcagaga      240

aggtaaaact ttctcttcgg aatttcccac ataatgatta tgaggatgtt tttgaagagc      300

cttcagaaag tggcagtgat cccagcatgt ggacagccag aggccccttc agaagagaca      360

ggtggagcag tgaggatgag gaggctgcag ggccatcaca ggctctctcc cctctacttt      420

ctgttcaaca tcatggatat agtggcccaa atgagagaac aacgttctgg catggttcaa      480

acgaaggagc agtatcactt ttgttacgat attgtgcttg aagttcttcg gaaacttctg      540

actttggatt aagaaagact tctgttgcct ctcacttgaa attaccaagt gggtttgca       599


<210> 3939
<211> 549
<212> DNA
<213> Homo sapiens

<400> 3939
gcattttacc ggcttggcct ctgacgggga tggggatggg ggtgggggag cgggaagacc       60

agcgatttca catttagaga accgactgct ggtcggaggc cgagatgggg ggaaagagcc      120

agttccgtcg ccttaaactg ccgtctggtt gtcaggcctc cccggtttcg tcgtcgacca      180

tgctgctttc ttttttgcca cttcttggga gaaaaatgtg gagaatatcg cgctgagcca      240

tgaataaggg tgggggagca atgggaagaa atattcgatg ggcttctcca aggccgaata      300

catcaagcaa tggtaacatc tttaaatgaa gataatgaaa gtgtaactgt tgaatggata      360

gaaaatggag atacaaaagg caaagagatt gacctggaga gcatcttttc acttaaccct      420

gaccttgttc ctgatgaaga aattgaaccc agtccagaaa cacctccacc tccagcatcc      480

tcagccaaag taaacaaaat tgtaaagaat cgacggactg tagcttctat taagaatgac      540

cctccttca                                                              549


<210> 3940
<211> 572
<212> DNA
<213> Homo sapiens

<400> 3940
agtgacgtta cttccctttt tccggtccgc cggattatga atgacggccg gcgcgagtat       60

tttccacata aggtggctgt cgtttttctc ctggcgtctg tggaggcgag tggtctgcgg      120

gcagcagctc ccagaggcag ccttggaatt ccagctcgga ctgggcggga aggcgcaggc      180

ggcccaggtc gccgacacgc tcacgcaccc tccctgcctg gccgcgcctc tgcgaccagg      240

taaagagggc gctcgggccg ccggcttctc agcctccgcg accccctaag aactggtctt      300

ttcttcgggg gtctgcaggg ctgaggatgc gggggaaggg tgggaaggac aagggcgtgg      360

tatcatcgtc ctgatttttc tcccgccctg gggccgcctc aaactccttt ttggccactc      420

ctgctgaagg tgacccaatg aaagaagaaa atgaaagcca taaagaaaag tcttacagaa      480

gaagaatacc tgtacctgga cttttctcac caaacagaag gatgcatctt tcctcttcat      540

acatctgtaa ctttatttct gttatcttac tg                                    572


<210> 3941
<211> 566
<212> DNA
<213> Homo sapiens

<400> 3941
aacggcggga aggctcaggg gcgtgcttgc ggcaaccctg taaccgccgg tgcgcaagtt       60

ggaggggcaa ggggctgccg tgtcctggtc tggaggcggc ccaggctgcc ttggtgattc      120

tggcttcgcg gcctcatggc ttgcggccgg tttgcgcaac ggcctgcgaa ccaccaggcg      180

cgtccccgcc ggcttgggtc cgccccgaag cccagtccct cggcctggcc cgctatgccc      240

tgcacactgg cggagtctgg cgtggcgcag cccggcgtgg ggttcggccc cgccaggtgg      300

tcagcccttc ctcggagtcc aggtggctgg gggcgcttcg gagagtggcc agttgccaaa      360

acaaagggga tttggtgatg gaggctttgt tagaaggaat acaaaatcga gggcatggtg      420

ggggattttt gacatcttgt gaagcagaac tacaggagct catgaaacag attgacataa      480

tggtggctca taaaaaatct gaatgggaag gacgtacaca tgctctagaa acttgcttga      540

aaatccgtga acaggaactt aagagt                                           566


<210> 3942
<211> 818
<212> DNA
<213> Homo sapiens

<400> 3942
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg aatttcccac      120

ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat cccagcatgt      180

ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag gaggctgcag      240

ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt tctgaaggag      300

aactagatca gttggctcag attcggccat taatattcaa ttttcatgag cagacagcca      360

tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc atgcaggaat      420

ttatgacggg aactagtcac tctgtaaaac agttgcagtt caccaagtgg ccagaccatg      480

gcactcctgc ctcagcagat agcttcataa aatatattcg ttatgcaagg aagagccacc      540

ttacaggacc catggttgtt cactgcagtg ccggcatagg ccggacaggg gtgttcctat      600

gtgtggatgt cgtgttctgt gccatcgtaa agaactgttc attcaacatc atggatatag      660

tggcccaaat gagagaacaa cgttctggca tggttcaaac gaaggagcag tatcactttt      720

gttacgatat tgtgcttgaa gttcttcgga aacttctgac tttggattaa gaaagacttc      780

tgttgcctct cacttgaaat taccaagtgg gtttgcac                              818


<210> 3943
<211> 3000
<212> DNA
<213> Homo sapiens

<400> 3943
cgcgcgtgtg tccgcgcgtg tccgcgtgtg ggtccgtgtg cgcgtcccgg tcccgcggcg       60

gcgacggcgg cggcggcggc ggcggctgca ggacgagccg agaggctcag ccatatttga      120

tggttttgtt gctttgctcg ggagttctcg ggagtaattt aatgccgaag gtcgctgcct      180

agtggaaata atataatacg tcattaatat ggcgccaaaa gattgggttc tcgatctgta      240

gcgaggaggg agggaggcag ccgctgagcg cagcgttact atcccaccag taacttgggc      300

attgccgggg cgggggccgg aggaggagga gaggatgatt tttggatcct gagaattgat      360

ctatgttgga tcagctgcct gctgtttccc ggggagatca tgaaacgagg tcgccttccc      420

agcagcagtg aggattctga cgacaatggc agcctgtcaa ctacttggtc ccagaattcc      480

cgatcccagc ataggagaag ctcctgctcc agacatgaag atcgaaagcc ttcagaggtg      540

tttaggacag acctgatcac tgccatgaag ttgcatgact cctaccagct gaatccggat      600

gagtactatg tgttggcaga tccctggaga caggaatggg agaaaggggt ccaggtgcct      660

gtgagcccgg ggaccatccc tcagcctgtg gccagggttg tgtctgaaga gaaatccctc      720

atgttcatca ggcccaagaa gtacatcgtg tcatcaggct ctgagcctcc cgagttgggc      780

tatgtggaca tccggacgct ggctgacagc gtgtgtcgct atgacctcaa tgacatggat      840

gctgcatggc tggaactgac caatgaagaa tttaaggaga tgggaatgcc tgaactagat      900

gaatacacca tggagagggt cctagaggaa tttgagcagc gatgctacga caatatgaat      960

catgccatag agactgagga aggcctgggg atcgaatatg atgaagatgt tgtctgtgat     1020

gtctgccagt ctcctgatgg tgaggacggc aatgagatgg tgttctgtga caaatgcaac     1080

atctgtgtgc accaggcctg ttatggaatc ctcaaggtac cagagggcag ctggctgtgc     1140

cggacatgtg ccctgggggt tcagccaaaa tgtctgctgt gtccgaagaa gggtggagct     1200

atgaagccca cccgtagcgg aaccaagtgg gtccacgtta gctgtgctct gtggatccct     1260

gaggtgagca ttggcagccc agagaagatg gagcccatca ccaaggtgtc acacattccc     1320

agcagccggt gggcgctagt gtgcagcctc tgcaatgaga agtttggggc ctctatacag     1380

tgctctgtga agaactgccg cacagccttc catgtgacct gtgcttttga ccggggcctg     1440

gagatgaaga ccatcttagc agagaatgat gaagtcaagt tcaagtccta ttgcccaaag     1500

cacagctcac ataggaaacc cgaggagagt cttggcaagg gggctgcaca ggagaatggg     1560

gcccctgagt gttccccccg gaatccgctg gagccctttg ccagccttga gcagaaccgg     1620

gaggaggccc accgggtgag tgtccgtaag cagaagctgc agcagttgga ggatgagttc     1680

tacaccttcg tcaacctgct ggatgttgcc agggctctgc ggctgcctga ggaagtagtg     1740

gatttcctgt accagtactg gaagttgaag aggaaggtca acttcaacaa gcccctgatc     1800

accccaaaga aagatgaaga ggacaatcta gccaagcggg agcaggatgt cttatttagg     1860

aggctgcagc tgttcacgca cctgcggcag gacctggaga gggttcggaa cctcacttac     1920

atggtgaccc gcagggaaaa gattaaacgg tctgtgtgca aagtccagga acagatattc     1980

aatctttaca ctaagctttt ggagcaagaa agagtttcag gtgtgccttc ttcctgctcc     2040

tcctcctcac tggaaaacat gcttttgttt aacagtcctt ctgttggccc tgatgctccc     2100

aagatagagg acttgaagtg gcattctgca ttcttcagaa aacaaatggg tacttccttg     2160

gttcattcgc tgaaaaagcc ccataagcga gatcctttgc agaatagccc tggaagtgaa     2220

ggcaaaaccc tgctgaagca gccagacctg tgtggtagaa gggaggggat ggtggtccca     2280

gagagctttt tgggtttaga aaagaccttt gcagaagcac gtctcatatc agcacaacag     2340

aaaaatggtg tggtgatgcc agaccatggg aaaagaagag acaatcgttt tcattgtgat     2400

ctcattaaag gagacttaaa ggacaaatct tttaaacaga gtcacaagcc tctcaggtcc     2460

acagatgtgt cccagaggca tctggacaac acaagagctg ccacctcccc tggagtgggg     2520

cagtcagcac ctggcacaag gaaggagata gtgcccaagt gcaatggctc cctaatcaaa     2580

gtaaactata atcagactgc agtcaaagtg cctacaacac ctgccagccc agtgaaaaac     2640

tggggaggat tccggattcc aaagaagggg gaacggcagc agcagggaga ggcccacgat     2700

ggggcctgcc accagcactc agactaccca tatttgggct taggccgagt tccagccaag     2760

gaaagggcaa aaagcaaatt aaaatccgac aatgagaatg acgggtatgt ccccgatgtg     2820

gaaatgagtg actcagagag tgaggcatca gaaaagaaat gtatacacac cagcagcact     2880

atcagcagaa ggacagacat tatcaggaga agcatcttgg cttcttgatg caacagagat     2940

gatgcggaag ccctttgggc tcgtcattgg gtttgctaga ggagagctct gatgtggggg     3000


<210> 3944
<211> 2747
<212> DNA
<213> Homo sapiens

<400> 3944
gcatagctaa cttgcacatt cactatccaa gctgcaccat cttcggggtc attgtgtgcc       60

aggcatatca actcttttca ataaaaatgg atggaaaggc agatgtaaag tccctcatgg      120

cgaaatataa cacggggggc aacccgacag aggatgtctc agtcaatagc cgacccttca      180

gagtcacagg gccaaactca tcttcaggaa tacaagcaag aaagaactta ttcaacaacc      240

aaggaaatgc cagccctcct gcaggaccca gcaatgtacc taagtttggg tccccaaagc      300

cacctgtggc agtcaaacct tcttctgagg aaaagcctga caaggaaccc aagcccccgt      360

ttctaaagcc cactggagca ggccaaagat tcggaacacc agccagcttg accaccagag      420

accccgaggc gaaagtggga tttctgaaac ctgtaggccc caagcccatc aacttgccca      480

aagaagattc caaacctaca tttccctggc ctcctggaaa caagccatct cttcacagtg      540

taaaccaaga ccatgactta aagccactag gcccgaaatc tgggcctact cctccaacct      600

cagaaaatga acagaagcaa gcgtttccca aattgactgg ggttaaaggg aaatttatgt      660

cagcatcaca agatcttgaa cccaagcccc tcttccccaa acccgccttt ggccagaagc      720

cgcccctaag taccgagaac tcccatgaag acgaaagccc catgaagaat gtgtcttcat      780

caaaagggtc cccagctccc ctgggagtca ggtccaaaag cggcccttta aaaccagcaa      840

gggaagactc agaaaataaa gaccatgcag gggagatttc aagtttgccc tttcctggag      900

tggttttgaa acctgctgcg agcaggggag gcccaggtct ctccaaaaat ggtgaagaaa      960

aaaaggaaga taggaagata gatgctgcta agaacacctt ccagagcaaa ataaatcagg     1020

aagagttggc ctcagggact cctcctgcca ggttccctaa ggccccttct aagctgacag     1080

tgggggggcc atggggccaa agtcaggaaa aggaaaaggg agacaagaat tcagccaccc     1140

cgaaacagaa gccattgcct cccttgttta ccttgggtcc acctccacca aaacccaaca     1200

gaccaccaaa tgttgacctg acgaaattcc acaaaacctc ttctggaaac agtactagca     1260

aaggccagac gtcttactca acaacttccc tgccaccacc tccaccatcc catccggcca     1320

gccaaccacc attgccagca tctcacccat cacaaccacc agtcccaagc ctacctccca     1380

gaaacattaa acctccgttt gacctaaaaa gccctgtcaa tgaagacaat caagatggtg     1440

tcacgcactc tgatggtgct ggaaatctag atgaggaaca agacagtgaa ggagaaacat     1500

atgaagacat agaagcatcc aaagaaagag agaagaaaag ggaaaaggaa gaaaagaaga     1560

ggttagagct ggagaaaaag gaacagaaag agaaagaaaa gaaagaacaa gaaataaaga     1620

agaaatttaa actaacaggc cctattcaag tcatccatct tgcaaaagct tgttgtgatg     1680

tcaaaggagg aaagaatgaa ctgagcttca agcaaggaga gcaaattgaa atcatccgca     1740

tcacagacaa cccagaagga aaatggttgg gcagaacagc aaggggttca tatggctata     1800

ttaaaacaac tgctgtagag attgactatg attctttgaa actgaaaaaa gactctcttg     1860

gtgccccttc aagacctatt gaagatgacc aagaagtata tgatgatgtt gcagagcagg     1920

atgatattag cagccacagt cagagtggaa gtggagggat attccctcca ccaccagatg     1980

atgacattta tgatgggatt gaagaggaag atgctgatga tggctccaca ctacaggttc     2040

aagagaagag taatacgtgg tcctggggga ttttgaagat gttaaaggga aaagatgaca     2100

gaaagaaaag tatacgagag aaacctaaag tctctgactc agacaataat gaaggttcat     2160

ctttccctgc tcctcctaaa caattggaca tgggagatga agtttacgat gatgtggata     2220

cctctgattt ccctgtttca tcagcagaga tgagtcaagg aactaatgtt ggaaaagcta     2280

agacagaaga aaaggacctt aagaagctaa aaaagcagga aaaagaagaa aaagacttca     2340

ggaaaaaatt taaatatgat ggtgaaatta gagtcctata ttcaactaaa gttacaactt     2400

ccataacttc taaaaagtgg ggaaccagag atctacaggt aaaacctggt gaatctctag     2460

aagttataca aaccacagat gacacaaaag ttctctgcag aaatgaagaa gggaaatatg     2520

gttatgtcct tcggagttac ctagcggaca atgatggaga gatctatgat gatattgctg     2580

atggctgcat ctatgacaat gactagcact caactttggt cattctgctg tgttcattag     2640

gtgccaatgt gaagtctgga ttttaattgg catgttattg ggtatcaaga aaattaatgc     2700

acaaaaccac ttattatcat ttgttatgaa atcccaatta tctttac                   2747


<210> 3945
<211> 913
<212> DNA
<213> Homo sapiens

<400> 3945
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg acgggaacta gtcactctgt      540

aaaacagttg cagttcacca agtggccaga ccatggcact cctgcctcag cagatagctt      600

cataaaatat attcgttatg caaggaagag ccaccttaca ggacccatgg ttgttcactg      660

cagtgccggc ataggccgga caggggtgtt cctatgtgtg gatgtcgtgt tctgtgccat      720

cgtaaagaac tgttcattca acatcatgga tatagtggcc caaatgagag aacaacgttc      780

tggcatggtt caaacgaagg agcagtatca cttttgttac gatattgtgc ttgaagttct      840

tcggaaactt ctgactttgg attaagaaag acttctgttg cctctcactt gaaattacca      900

agtgggtttg cac                                                         913


<210> 3946
<211> 805
<212> DNA
<213> Homo sapiens

<400> 3946
ctcgaatgca gcgtctacgc ctggtgaatg gacgcactct taccaattct gctctgggag       60

atgcagcggt aacctaccga gcgcagaggc cggcgcgcac ccgtggagcc cgcgctcgcg      120

atccctcctc gtgccagggc cccagggcag tcaaggcctg ccgaccgtta ggcgggtcaa      180

ggggtacaca gggtgcgaat tcgttaggca aaagctgggt acaggcgcga gccacaggca      240

cggaaacctc gcgccgaccg gggccctagg cccgacgacg gcagtttgtt tcgacgccgg      300

accgcgtaag agacgatgat gttgggcacg gaaggtggag agggattcgt ggtgaaggtc      360

cggggcttgc cctggtcttg ctcggccgat gaagtgcaga ggtttttttc tgactgcaaa      420

attcaaaatg gggctcaagg tattcgtttc atctacacca gagaaggcag accaagtggc      480

gaggcttttg ttgaacttga atcagaagat gaagtcaaat tggccctgaa aaaagacaga      540

gaaactatgg gacacagata tgttgaagta ttcaagtcaa acaacgttga aatggattgg      600

gtgttgaagc atactggtcc aaatagtcct gacacggcca atgatggctt tgtacggctt      660

agaggacttc cctttggatg tagcaaggaa gaaattgttc agttcttctc agggttggaa      720

atcgtgccaa atgggataac attgccggtg gacttccagg ggaggagtac gggggaggcc      780

ttcgtgcagt ttgcttcaca ggaaa                                            805


<210> 3947
<211> 759
<212> DNA
<213> Homo sapiens

<400> 3947
atggcggcga cggcccggga agatggcgcc agcggtcaag agcgaggtca gcggggctgc       60

gagcactatg acagaggatg tctcctaaag gcaccttgct gtgacaagct ttatacttgc      120

cgcttgtgtc atgataacaa tgaagatcat caactagatc gctttaaagt gaaggaagtg      180

cagtgcataa actgtgaaaa aattcaacat gcccaacaga cttgtgaaga atgtagcaca      240

ttgtttggag aatattattg cgatatatgc catttgtttg acaaagataa gaagcagtat      300

cactgtgaaa actgtggaat ttgtaggatt ggtccaaagg aagatttttt ccattgtttg      360

aaatgtaact tatgcctagc tatgaatctt caaggaagac acaagtgtat tgaaaatgtg      420

tcccgacaga attgtccaat atgtttggag gacattcaca catcccgtgt tgttgctcat      480

gtcttgccat gtggacatct tttacataga ggctacagat gtccattatg tatgcactct      540

gctttagata tgaccaggta ttggagacag ctggatgatg aagtagcaca gactcctatg      600

ccatcagaat atcagaacat gactgtggat attctctgca atgactgtaa tggacgatcc      660

actgttcagt ttcatatatt aggcatgaaa tgtaagattt gtgaatccta taatactgct      720

caagctggag gacgtagaat ttcactggat cagcaatga                             759


<210> 3948
<211> 818
<212> DNA
<213> Homo sapiens

<400> 3948
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg aatttcccac      120

ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat cccagcatgt      180

ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag gaggctgcag      240

ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt tctgaaggag      300

aactagatca gttggctcag attcggccat taatattcaa ttttcatgag cagacagcca      360

tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc atgcaggaat      420

ttatgacggg aactagtcac tctgtaaaac agttgcagtt caccaagtgg ccagaccatg      480

gcactcctgc ctcagcagat agcttcataa aatatattcg ttatgcaagg aagagccacc      540

ttacaggacc catggttgtt cactgcagtg ccggcatagg ccggacaggg gtgttcctat      600

gtgtggatgt cgtgttctgt gccatcgtaa agaactgttc attcaacatc atggatatag      660

tggcccaaat gagagaacaa cgttctggca tggttcaaac gaaggagcag tatcactttt      720

gttacgatat tgtgcttgaa gttcttcgga aacttctgac tttggattaa gaaagacttc      780

tgttgcctct cacttgaaat taccaagtgg gtttgcac                              818


<210> 3949
<211> 5361
<212> DNA
<213> Homo sapiens

<400> 3949
gcctcctccg ccacctccac cgatgtggaa tccaatgatt cctgcttttg acctcttcca       60

aggaaaccat ggctttgtag ctcctgttgt aaccacagct gcacactgga gatctgtcaa      120

ctacacattt ccaccctcag ttatttctca cacttcccca acaaaagtat ggagaaataa      180

agatggaaca agtgcttatc aagtacaaga aaccccagtt tctcaggttg taagaaagaa      240

gacatcttac gttggactag ttcttgttct tctcagaggt cttccgggat ctggaaaatc      300

ttttttggca aggactttgc aagaggataa tccaagtgga gtcattctta gtactgatga      360

ttatttttat ataaatggac agtaccagtt tgatgtaaag tacttaggag aagcacatga      420

atggaaccag aatcgtgcaa aagaagcatt tgagaagaag atatctccta taattataga      480

taatacaaac ctacaggcat gggaaatgaa accatatgtt gctttgtctc agaaacacaa      540

atataaagtc ctttttcggg aaccagacac atggtggaag tttaaaccaa aggaacttgc      600

aaggcgtaac attcatgggg taagcaaaga aaaaataaca agaatgttgg aacattatca      660

acgttttgtt tcagtgccaa taattatgag ttcttcggtt ccagagaaaa ttgaacgtat      720

tgagttgtgt gcatattctt gtgaggatag aagcactagc ccaagagacg atgaagatat      780

tatctctgaa aaagaagaaa atattttatc tttatctttg aagcatctag agttcactga      840

agagaagaat cttgatgtaa ccaaagaaac aatgttacct gagaatgttg catatctctc      900

taatgcagat ttaaacaaaa gaagaaaaga aataagtgat atgaatccta gcattcaaag      960

tgctttaatt ctggaaactc cacacatgta tttttctgac tctgaaagca aactacaggc     1020

aacagacaaa agtgaaaacg agcaaataga aatggtggct gtaaaagggt atagtaaaac     1080

tgacacagat agttctatgg agagagtatc acctagtact tgctgtagtg aaaataatca     1140

agaagactgt gatcttgcaa atagtggacc acttcaaaat gaaaaatcct cacctggtga     1200

aatagtggaa gaaagagcaa cagtaacgaa aaaagccttt gggaaacaaa aaagcaaatc     1260

gactttggaa aagttcccaa gacatgagct atcaaatttt gttggtgact ggccagttga     1320

taagactatt ggtcagagga caaaaaggaa cagaaaaact gaaaaaactt catccgtaca     1380

aagcgacaaa aagtataatt accctcagtc acacaaatta gttaacagtg tatctgtgaa     1440

tacagattgt gtccagcaac gaggatctcc acatgaaagt gtagaggatg gcagaaagtc     1500

acagtgtgat gatgcttcag agccactcaa tagctataaa tatgatgctt ataaaaatat     1560

tgacaaaaac tcattcaaca ttatgggtga ctggccttca tctgattctt tagctcagag     1620

ggaacacaga tcaagaatgc caaagactgg tttaagtgag cccaacctag aaattggaac     1680

aaatgacaaa atgaatgaaa tatccttatc tacagcacat gaggcctgtt ggggcacaag     1740

ctctcaaaaa ctaaagacat tgggtagctc caatctagga agttctgaaa tgctgctcag     1800

tgaaatgacc tgtgagagtc agacttgtct aagtaaaaag agtcatgggc aacacacatc     1860

gttgcctctt acttttacca atagtgcacc aactgtttct ggagtagtag aaccacaaac     1920

gttagctgaa tgtcaagagc aaatgcctaa gagagaccct ggaaaagaag taggcatgtg     1980

cacccagact gaaccacagg attttgctct tttatggaaa atagaaaaga ataaaattag     2040

catttcagat tctatcaaag tattaacagg aagattagat ggatttaagc cgaaagtttt     2100

caatattaac acaaaatcag acgttcaaga agcaattcca tatagagtaa tgtatgataa     2160

aagcacgttt gttgaagaaa gtgagcttac cagtgcagat gaatctgaaa atcttaacat     2220

tctttgtaaa ctgtttggat ccttttcatt agaagccctg aaagacttat atgagaggtg     2280

caataaagat attatttggg ccacaagcct tttgttggat tctgaaacta agttatgtga     2340

ggatacagag tttgagaatt tccaaaaatc gtgtgatgga tcacaaattg ggcctttttc     2400

tctggggttg aatttgaaag aaattattag ccaaagagga actttagaga attctaattc     2460

tcctgtgcca gagtttagcc atgggattgg tattagtaac gctgactcac agtctacttg     2520

tgatgcagaa agaggaaact cagagcaggc ggaaatgaga gctgtcactc ctgaaaacca     2580

tgaatcgatg acaagtatat ttcccagtgc tgctgtgggt ctaaagaata ataatgacat     2640

acttcctaac agccaggaag aacttttata tagcagtaag cagtcctttc caggtattct     2700

aaaagctact actcctaaag atatgagtga aacagaaaaa aacctagtag tcacagagac     2760

tggagacaac atacattctc cttcacattt ctctgatatt tttaactttg tatctagtac     2820

ttcaaatctt gaattaaatg aagaaattta ttttactgat tctcttgaaa taaagagaaa     2880

tgaaaatttt ccaaaggatt atgtgaaatt ttcagatgaa gaagaattta tgaatgaaga     2940

tgagaaggaa atgaaggaaa ttctaatggc aggaagtagt ttatcagctg gagttagtgg     3000

ggaagataaa accgagatat tgaatcccac tccagcgatg gccaaatctc tgaccataga     3060

ctgtctggaa ttggcattac cccctgaact ggcttttcaa cttaatgaat tatttggtcc     3120

tgttggtatt gattcagggt ctctaacagt tgaagattgt gtggttcata tagatctgaa     3180

tctggcgaaa gtgattcatg agaaatggaa agaatctgta atggagcgac aaagacaaga     3240

agaggtgtct tgtggcaagt ttatgcaaga tccttccttg gttggacata ctgggcttga     3300

taatcctgaa caaaaatcat ctcagagaac aggcaaaaaa ttactgaaga ctttaacagc     3360

atctgaaatg ctacctttat tggatcattg gaatactcaa actaaaaaag tatcactcag     3420

agaaataatg tcagaagaaa ttgccttaca ggaaaaacat aatttgaaaa gggagaccct     3480

tatgtttgaa aaagattgtg ccactaaact aaaggagaag cagctcttta agatatttcc     3540

agccattaac caaaattttc tggtggacat tttcaaggac cacaactatt cattagaaca     3600

cacagtgcaa tttcttaact gtgttcttga aggggaccct gtaaaaacag ttgtagccca     3660

agagtttgtt caccaaaatg agaatgtcac atctcatact ggccagaagt ctaaagagaa     3720

aaaggacttt gagtacccag actatgatga ctacagagca gaggctttcc ttcaccaaca     3780

gaagaggatg gagtgctaca gcaaggccaa agaagcttat cggataggga aaaaaaatgt     3840

cgccaccttt tatgcccagc agggtactct tcatgagcag aagatgaaag aagccaatca     3900

ccttgctgcc atagagatct ttgagaaagt caatgcttcg ctgctgccac agaatgtttt     3960

agacctccat gggctgcatg tggatgaagc tctagaacat ttgatgagag ttttagagaa     4020

gaagactgaa gaatttaagc agaacggtgg gaagccctat ttgtctgtga ttacggggag     4080

aggaaaccac agccagggag gagttgctcg catcaaacca gctgtcatta agtacctcat     4140

aagccatagc ttcaggttct ctgaaattaa accagggtgc ttgaaagtca tgctaaagta     4200

aaataaacat ccttgaatta gaagtatgaa ggtttgtagg ttaaaattac ttttatttgc     4260

agtaattcag tcaattctac cctaaagatg tgttttatta taaataatat tcaattatga     4320

aacaaaaaaa ttatgatgtt tttcaaaatg caagtgaggt ttgatttttt actgaatcaa     4380

atgcaaatgt tacctgttaa agatattaca gagaaatttt attgattaca aaatatgtaa     4440

gaaaattatc agctacagtt ttaaagttta aaatgctctg attgtttctc agaaaaggtt     4500

acctttgtat taattgttgt atgacattta gtaatgtcct aaaagtcttt tgtgagaggt     4560

atttaaagtg ctttgagacc tgattcatgc cccccaaagg gtggtattaa aagaggaaaa     4620

aggacatagt agtggtagta aagaaaaaaa ggagatctaa caaaaacact tgaatatttt     4680

ttattttcaa aactaaacac ataaaatgct tttattttgc catatcctac aggaaggaag     4740

acatgctttt gccctttctt ctgctttgta tatgaccttg atcttttacc ttttgttctg     4800

ttcttctgtg tgcattttat ggaaagaaag ttgggtctga gattatattg taattttata     4860

ctttctatag acagaaaggt tttcagagaa aaagaaatgg ttaaatatct tccagatgtt     4920

gctgccttat cgaaatgctt ctagaactgt ctgtataagt cgtatttcag acagtactaa     4980

atacttatat tttatttttg aggcatgtaa ttttaaaact gcagtaggtt aaaattctat     5040

taaacaaata tagaaaatat tttgtttata attggcctgg tgtggtggcc cacgcctgta     5100

atcccagcac tttgggaggc cgaggtaggt ggatcgcctg aggtcagaag ttcaagacca     5160

gcctggccaa catggtgaat ccccgtctct attaaaaata caaaaattag ctgggtgtgg     5220

tggcgtgtgc ctgtaatccc agctacttgg gaggctgagg caggagaacc gcttaaacct     5280

gggaggtgga ggttgcagtg acccgagatc gagatcacac cactgcactc agcctgggtg     5340

acagagcaag actccgtctc c                                               5361


<210> 3950
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3950
aggaaacgct gccgaggagt aggcggggcg ggcgctttgg ttccgagggt gcttctgctc       60

cgactgcttt tcccacgggc gtcatctata gtccggagga cagccccagg gcagaggcct      120

ctgaactgca aggtgtggaa tatttctggc ttctagtcca atgccaagtg tgtgacctgt      180

gagttaattc tgcattttag ttttggccct acatttattt aaagcctgaa tttggggagt      240

atctgcaaag cactgaaggt tttggacatt gtcttttcct gctgttgaaa gagaccctct      300

tcatatatac aacattcagg ctacatgatt ccctgaaaga taagaacaat gttatgttgg      360

ggatattggt ctctgggcca acctggtatc agcaccaacc tgcagggaat tgtggctgag      420

ccccaggtgt gtgggttcat atctgacaga agtgtcaagg aagtggcctg tgggggaaac      480

cactctgtgt tcctgctgga agatggggaa gtttacacat gtggtttgaa caccaagggg      540

caactgggcc atgagaggga aggaaacaag ccagaacaaa tt                         582


<210> 3951
<211> 1288
<212> DNA
<213> Homo sapiens

<400> 3951
ttttcctgcc tgtgagggtg gacagatcgc gctcgggtct cggcctcctg agtgccggaa       60

agatgaatgg gagggctgat tttcgagagc cgaatgcaga ggttccaaga ccaattcccc      120

acatagggcc tgattacatt ccaacagagg aagaaaggag agtcttcgca gaatgcaatg      180

atgaaagctt ctggttcaga tctgtgcctt tggctgcaac aagtatgttg attactcaag      240

gattaattag taaaggaata ctttcaagtc atcccaaata tggttccatc cctaaactta      300

tacttgcttg tatcatggga tactttgctg gaaaactttc ttatgtgaaa acttgccaag      360

agaaattcaa gaaacttgaa aattcccccc ttggagaagc tttacgatca ggacaagcac      420

gacgatcttc accacctggg cactattatc aaaagtcaaa atatgactca agtgtgagtg      480

gtcaatcatc ttttgtgaca tccccagcag cagacaacat agaaatgctt cctcattatg      540

agccaattcc attcagttct tctatgaatg aatctgctcc cactggtatt actgatcata      600

ttgtccaagg acctgatccc aaccttgaag aaagtcctaa aagaaaaaat attacatatg      660

aggaattaag gaataagaac agagagtcat atgaagtatc tttaacacaa aagactgacc      720

cctcagtcag gcctatgcat gaaagagtgc caaaaaaaga agtcaaagta aacaagtatg      780

gagatacttg ggatgagtga aaaattacat cattggacat gaaggagttt caacatccag      840

cttcatctag gtggtcatga ttacctgcat gctttgagct cagcagcagt cttcataaac      900

acatttaaaa caagatcctg ggtttttgtg gtttgacttc tatggtgttt taaaaaaaca      960

cagattttta gtgttaatat tgtgtaaatg tactcacctt agggattcat ttgaatgatg     1020

gtattatacc atgattgtat acagtttgtg aaattgttgc aagggcaaag ataactctta     1080

aaaaaccgtc gagattacaa tgctctagaa tcagcatata agaaaataaa tgatatctgc     1140

atgttgaatt ggggtggatg gggggagcaa gcataatttt taagtgtgaa gctttgcatc     1200

aagaaattat taaaaagctt tttttctcca gtattttctg tattatctta atgtttatgg     1260

caaataaaat gtaaaggaac atgcaaca                                        1288


<210> 3952
<211> 2770
<212> DNA
<213> Homo sapiens

<400> 3952
gtgcttgcgg caaccctgta accgccggtg cgcaagttgg aggggcaagg ggctgccgtg       60

tcctggtctg gaggcggccc aggctgcctt ggtgattctg gcttcgcggc ctcatggctt      120

gcggccggtt tgcgcaacgg cctgcgaacc accaggcgcg tccccgccgg cttgggtccg      180

ccccgaagcc cagtccctcg gcctggcccg ctatgccctg cacactggcg gagtctggcg      240

tggcgcagcc cggcgtgggg ttcggccccg ccaggtggtc agcccttcct cggagtccag      300

gtggctgggg gcgcttcgga gagtggccag gggcccccaa acccggggcc gcagagcagt      360

accagtccgt ggcctgttag gaaccaggct acagagcagg agttgccaaa acaaagggga      420

tttggtgatg gaggctttgt tagaaggaat acaaaatcga gggcatggtg ggggattttt      480

gacatcttgt gaagcagaac tacaggagct catgaaacag attgacataa tggtggctca      540

taaaaaatct gaatgggaag gacgtacaca tgctctagaa acttgcttga aaatccgtga      600

acaggaactt aagagtctta ggagtcagtt ggatgtgaca cataaggagg ttggaatgtt      660

gcatcagcag gtagaagaac atgaaaaaat caagcaagag atgaccatgg aatataagca      720

ggagttgaag aaactacatg aagaattatg catactgaag agaagctatg aaaagcttca      780

gaaaaagcaa atgagggaat tcagaggaaa taccaaaaat cacagggaag atcggtctga      840

aattgagagg ttaactgcaa aaatagagga attccgtcag aaatcgctgg actgggagaa      900

gcaacgcttg atttatcagc aacaggtatc ttcactggag gcacaaagga aggctctggc      960

tgaacaatca gagataattc aggctcagct tgtcaatcgg aaacagaaat tagagtctgt     1020

ggaactttct agccaatcag aaattcaaca cttaagcagt aaactggagc gggctaatga     1080

cactatctgt gccaatgagt tggaaataga gcgcctcacc atgagggtca atgacttggt     1140

tggaaccagt atgactgtcc tacaggagca gcagcaaaaa gaagaaaaat tgagggaatc     1200

tgaaaaacta ttagaggctc tgcaggaaga aaagagagaa ttgaaggcag ctcttcagtc     1260

tcaagaaaat ctcatacatg aggccagaat acaaaaggag aagttacaag aaaaagtaaa     1320

ggcaactaac actcaacatg ctgtagaagc tataaggcca cgggaagaat ctctggcaga     1380

aaagaagtac acctctcaag ggcaggggga cttagacagt gtgctctccc agttgaattt     1440

tacccatact agtgaggacc ttctgcaggc agaggtgact tgtcttgaag gcagtttgga     1500

atctgtgagt gcaacgtgta aacagctgag ccaagaacta atggaaaaat atgaagaact     1560

gaagaggatg gaagcacata acaatgaata caaagcagag attaagaagt tgaaagaaca     1620

gattttacag ggtgaacaaa gttacagttc tgcactagaa ggaatgaaga tggaaatctc     1680

ccatctaact caggagttac atcagcgaga tatcactatt gcttccacca aaggttcttc     1740

ctcagacatg gaaaagcgac tcagagcaga gatgcaaaag gcagaagaca aagcagtaga     1800

gcataaggag attttggatc agctggagtc actcaaatta gaaaatcgtc atctttctga     1860

aatggtgatg aaattggaat tgggtttaca tgaggcaaaa gagatttcac tagcagacct     1920

ccaggagaat tatattgagg cattaaataa attagtgtct gaaaatcaac aactacagaa     1980

agatttgatg aataccaaat ctcagctgga gatttctact cagatgtgca aaaaacaaaa     2040

tgacaggatc tttaaaccaa cacacagcag aacaactgag ttcaagaata cagagttcaa     2100

gccaacccat ggccagcaca gacatgatgg aataaagact gagcactaca aaacagatct     2160

tcattctcca agaggacaag cgtcggatag tataaacccc atgtctaggg tgctaagccc     2220

cctgagtcct caaatcagcc cttgcagctc caccaggtct ttgacttcct actctctatg     2280

taaaactcat tctttgcctt cagcgctaga tacaaatgaa gccaattttt ctgacactat     2340

gtctgagagt atgaatgacc aagaagagtt tatatcttcg tgttccttgc ctgtatctcc     2400

ccttggttca atagctacca gatttttgga agaggaggaa ctgaggtctc atcacattct     2460

agagcgcttg gatgcccata ttgaagaact aaaaagagag agtgaaaaga cagtgagaca     2520

attcacagcc ttaaagtagc ctcttaaaaa aatcactatc ttggaaataa aaataaacac     2580

caaagagtta ctgtcatctg aagtagcagc tctttaaaaa catgaagaga taaaattata     2640

aaaatgatac atctaaagca gtggtgaaga aagctgaaaa actgatactt ttgataggca     2700

ttttctctgc actggtttgt ttaaaggact tcttccagca ataagttgaa agaataaacc     2760

actttgctag                                                            2770


<210> 3953
<211> 665
<212> DNA
<213> Homo sapiens

<400> 3953
aaggtggctt gggagggacc agttttccta gatgcaggag acagcgtcca tagtttcagt       60

tcgaagcaac tggtggcaaa aggttagcat ttaagatggc agggacagcg cgccatgacc      120

gagagatggc gatccaggcc aagaaaaagc tcaccacggc caccgacccc attgaaagac      180

tccgactgca gtgcctggcc aggggctctg ctgggatcaa aggacttggc agagtgttta      240

gaattatgga tgacgataat aatcgaaccc ttgattttaa agaatttatg aaagggttaa      300

atgattatgc tgtggtcatg gaaaaagaag aggtggaaga acttttccgg aggtttgata      360

aagatggaaa tggaacaata gacttcaatg aatttcttct cacattaaga cctccaatgt      420

ccagagccag aaaagaggta atcatgcaag cttttagaaa gttagacaag actggagatg      480

gtgttataac aatcgaagac cttcgtgaag tatataatgc aaaacaccac ccaaagtacc      540

agaatgggga atggagtgag gaacaagtat ttaggaaatt tctggataac tttgattcac      600

cctatgacaa agatggattg gtgacccctg aggagttcat gaactactat gcaggtgtga      660

gcgca                                                                  665


<210> 3954
<211> 582
<212> DNA
<213> Homo sapiens

<400> 3954
aatgtgctgt gtcacggcag agccgggctg tgtcgcggtg actcagcggg gccggtggtt       60

tcctaacgcc cggggctgag gcagcctggc ctgacccagc tgtactcgct taggtgacca      120

gcctcaccta gattttgcct ctgcacaagg gtcagctctt tctttgagaa tgtttcagaa      180

gatctgggtc taaccttgaa acagtgaggt cccaggtcgc tggccggctc tgcacctgtc      240

gccatccccg gctccctgcc cagagcacca tcgctacact cgccatcctc tgcgtccacc      300

tcgccgctcg gttcgctgtc ccagcccctc ccagggccgg tgggctcctc agccatgacg      360

cctccccagc agccgccacc cctgcgttca gagccgggca cactgggctc tgcagcctca      420

tcctacagcc ccctaggttt gaacggtgtc cccgggagca tctgggactt tgtttccggc      480

agcttctccc ccagcccctc ccccatcctg agtgccggcc ccccatcctc ttcgagtgca      540

agtccaaacg gagctgagct ggcccgggtc aggcggcagc tg                         582


<210> 3955
<211> 574
<212> DNA
<213> Homo sapiens

<400> 3955
gatgactaca tcataatggg aaggataagg cgttcctcaa aatggatgcc ataagtaaag       60

ggaagctgaa gcctgattaa cttcgtcagt gccacaggaa gaaacaagag acagaaggaa      120

aaagcacttt ggatgcccgc tgtaattcac agagatctcc acggtaggag cgggacgtca      180

gcttctgcgg ctaaaatctc gtgactgaag cagcacagat cagaaagaac gatttaccag      240

cagctgcaga ctacataatg aaaaataaca aaagtgccca tgcgcgaggc tgtgcaacta      300

accacccgac gattgcgggg aggaggagta agagtcggct aagcggcgcc cagtgtccta      360

ctgcgcctgt gcgccggtgg cgtgcgcaga ggcctctggg taggtggctc aaccccgcct      420

ctcagttgag gactctgaag gctgtttctg tggcgcttcc cctgcgagga tggctaccct      480

ggttgtaaac aagctcggag cgggagtaga cagtggccgg cagggcagcc gggggacagc      540

tgtagtgaag gtgctagagt gtggagtttg tgaa                                  574


<210> 3956
<211> 637
<212> DNA
<213> Homo sapiens

<400> 3956
cttatacact gggttccgag ccggtcttat cttccgctgg accacctcgc cgccctcagg       60

gattctggac aaatatggaa cgttgggtcg gttgccgggt cctcaaaatt ataaccgcca      120

ctggatctgc gctgtgcgtt ggctaaaaaa aagaaaagaa catggaggca gatataatca      180

caaatcttcg atgcaggctc aaagaggctg aagaagagcg actaaaagct gcacagtatg      240

gtttacaact agtagagagt caaaatgaat tacagaatca attggataaa tgtcgtaatg      300

aaatgatgac catgactgag agttatgaac aagaaaaata tacccttcaa agagaagttg      360

aactcaagag tcgaatgtta gaaagtttga gctgcgaatg tgaagctatt aaacaacaac      420

aaaaaatgca cctggagaaa ttggaagaac aactaagcag aagccatgga caggaagtga      480

atgaactaaa aactaagata gaaaaactga aagtggaatt agatgaagcc aggcttagtg      540

aaaagcagct gaagcaccaa gtagatcatc agaaggaact cctctcttgt aaatcagagg      600

aactgcgcgt aatgtctgaa cgtgtgcagg aaagcat                               637


<210> 3957
<211> 769
<212> DNA
<213> Homo sapiens

<400> 3957
aggcggagcg ctaacgtcta acgctaacgg cggtcgtgcc ccgccgctgc tgtcaccccc       60

ggccgctgct gccctccccg ccgaggttct actgctctcc ttcttaagaa gggtgggagg      120

cactcggtct ctccccacac ctctcgcctg aggccaggcg ccaggtgtcg cctgaagcca      180

gacagccggt ttgggagcga gcctgagttc caggcactgg gctaggcact gggatggtgt      240

ggtgagcaaa aactgaccag tcctgccgtg gagtttgctg ggggagacac atgttactca      300

aagaatcaca ctaaggatag caatttatct caaagcttca agttcctgcc atctacatgt      360

gcccaggtca accaatcaat ggctcagaca gataagccaa catgcatccc gccggagctg      420

ccgaaaatgc tgaaggagtt tgccaaagcc gccattcggg cgcagccgca ggacctcatc      480

cagtgggggg ccgattattt tgaggccctg tcccgtggag agacgcctcc ggtgagagag      540

cggtctgagc gagtcgcttt gtgtaactgg gcagagctaa cacctgagct gttaaagatc      600

ctgcattctc aggttgctgg cagactgatc atccgtgcag aggagctggc ccagatgtgg      660

aaagtggtga atctcccaac agatctgttt aatagtgtga tgaatgtggg tcgcttcacg      720

gaggagatcg agtggctgaa gtttttagcc cttgcttgca gcgctctgg                  769


<210> 3958
<211> 896
<212> DNA
<213> Homo sapiens

<400> 3958
tgagcgaatg ggccggcgac tgtggagtta gcgtcctcaa tgtggacgcc ctgagctccc       60

attaggagcc gctggctgcg gcagcagggg actagcgtga gagggattct ggacaaatat      120

ggaacgttgg gtcggttgcc gggtcctcaa aattataacc gccactggat ctgcgctgtg      180

cgttggctaa aaaaaagaaa agaacatgga ggcagatata atcacaaatc ttcgatgcag      240

gctcaaagag gctgaagaag agcgactaaa agctgcacag tatggtttac aactagtaga      300

gagtcaaaat gaattacaga atcaattgga taaatgtcgt aatgaaatga tgaccatgac      360

tgagagttat gaacaagaaa aatataccct tcaaagagaa gttgaactca agagtcgaat      420

gttagaaagt ttgagctgcg aatgtgaagc tattaaacaa caacaaaaaa tgcacctgga      480

gaaattggaa gaacaactaa gcagaagcca tggacaggaa gtgaatgaac taaaaactaa      540

gatagaaaaa ctgaaagtgg aattagatga agccaggctt agtgaaaagc agctgaagca      600

ccaagtagat catcagaagg aactcctctc ttgtaaatca gaggaactgc gcgtaatgtc      660

tgaacgtgtg caggaaagca tgtcttcaga gatgctggct cttcaaattg agctgacaga      720

aatggagagt atgaagacca ccctcaaaga agaagtgaat gaactacaat acagacaaga      780

acagctagaa cttcttatta ctaacctaat gcgccaggta gaccggctta aagaggaaaa      840

agaggagcga gagaaagaag cagtttctta ctataatgcc ctagagaaag ctcgtg          896


<210> 3959
<211> 1088
<212> DNA
<213> Homo sapiens

<400> 3959
gctacccctg gtgacctggc agcggagccc gcgcagggtt tgccaggcga aggcggagcg       60

ctaacgtcta acgctaacgg cggtcgtgcc ccgccgctgc tgtcaccccc ggccgctgct      120

gccctccccg ccgaggttct actgctctcc ttcttaagaa gggtgggagg cactcggtct      180

ctccccacac ctctcgcctg aggccaggcg ccaggtgtcg cctgaagcca gacagccggt      240

ttgggagcga gcctgagcaa tttatctcaa agcttcaagt tcctgccatc tacatgtgcc      300

caggtcaacc aatcaatggc tcagacagat aagccaacat gcatcccgcc ggagctgccg      360

aaaatgctga aggagtttgc caaagccgcc attcgggcgc agccgcagga cctcatccag      420

tggggggccg attattttga ggccctgtcc cgtggagaga cgcctccggt gagagagcgg      480

tctgagcgag tcgctttgtg taactgggca gagctaacac ctgagctgtt aaagatcctg      540

cattctcagg ttgctggcag actgatcatc cgtgcagagg agctggccca gatgtggaaa      600

gtggtgaatc tcccaacaga tctgtttaat agtgtgatga atgtgggtcg cttcacggag      660

gagatcgagt ggctgaagtt tttagccctt gcttgcagcg ctctgggagt tactattacc      720

aaaactctca agatagtgtg tgaggtctta tcatgtgacc acaatggtgg gttgccccga      780

atcccattca gcaccttcca gtttctctac acgtatattg ccgaagtgga tggggagatc      840

tgtgcatcac atgtcagcag gatgctaaac tacattgaac aggaagtaat tggtcctgat      900

ggtttaatca cggtgaatga ctttacccaa aaccccaggg tttggctgga gtaacagcac      960

aattttggca attttaaagg aagatacaga ggtgattgta cttcagaatg ataaacccat     1020

ataccaccta aaatcaattt tcttgtacaa ctggtacaca ctaataaaca aacatgtgag     1080

atcagaaa                                                              1088


<210> 3960
<211> 2844
<212> DNA
<213> Homo sapiens

<400> 3960
atgaatttcc tccgcggggt aatggggggt cagagtgccg gaccccagca cacagaagcc       60

gagacggtga gaggagcagc ggacccgaag gtcacctcca gctgtggact taaatttaga      120

catagttttc gtttagtcaa gcacatttta taccatgtta ctataaatgt gtattcagat      180

tctgaaataa taggttatgc tttggacaca ctatataata taatatctaa tgaagaagaa      240

gaagaagtag aagaaaattc cacaagacag agtgaagatt tgggaagcca atttacagaa      300

attttcatta agcagcagga aaatgtcact cttctgttat ctttattgga ggagtttgat      360

ttccatgtcc gctggcctgg tgtgaagctt cttacttctc ttttaaaaca actagggcct      420

caggtgcaac aaattatttt agtcagtcct atgggtgttt caagattgat ggacttacta      480

gcggattcca gggaagttat acgtaatgat ggcgtcttac tactgcaggc actaacaaga      540

agcaatggtg caatccagaa aattgttgct tttgaaaatg ctttcgagag actactggac      600

attatttcag aggaggggaa cagtgatgga ggtatagtag ttgaagattg tttgattttg      660

ctccaaaact tattaaaaaa caacaactcc aatcaaaatt tttttaaaga aggctcatat      720

attcaacgta tgaaaccttg gtttgaagtt ggagatgaaa attctggctg gtctgcacag      780

aaagtgacca atctacatct aatgctacag cttgttcgtg tattggtatc tcccaccaac      840

cctcctggtg ctaccagtag ctgccagaag gctatgttcc agtgtgggtt attgcagcag      900

ctttgtacta tcctaatggc tactggggtt cctgctgata tcctgactga gaccataaat      960

actgtatcag aagttattcg aggctgccaa gtaaaccaag actactttgc atctgtaaat     1020

gcaccttcaa acccaccaag accggcaatt gtagtacttc tcatgtccat ggttaatgaa     1080

aggcagccat ttgttttgcg ctgtgctgtt ctctattgtt tccagtgttt cttgtataaa     1140

aaccaaaaag gacaaggaga aatcgtgtca acacttttac cttctaccat tgatgcaaca     1200

ggtaattcag tttcagctgg ccagttatta tgtggaggtt tgttttctac tgattcactt     1260

tcaaactggt gtgctgctgt ggcccttgcc catgcgttgc aagaaaatgc cacccagaaa     1320

gaacagttgc tcagggttca acttgctaca agtattggca accctccagt ttctttactt     1380

caacagtgca ccaatattct ttcacaggga agcaaaatac aaacaagagt tggattatta     1440

atgttgcttt gtacctggct aagcaattgt cccattgcag taacgcattt tcttcacaat     1500

tcagccaatg ttccatttct tacaggacaa attgcagaaa atcttggaga agaagagcag     1560

ttggtccaag gcttatgtgc ccttttgttg ggcatttcga tttatttcaa tgataactca     1620

cttgagagct acatgaaaga gaagctaaaa caactgattg agaagaggat tggcaaagag     1680

aatttcatag agaaactagg atttattagc aaacatgagt tgtattccag agcatctcag     1740

aaaccccagc caaactttcc cagtccagaa tacatgatat ttgatcatga gtttacgaag     1800

ctggtaaaag aacttgaagg tgttataact aaggctattt ataagtccag tgaagaagat     1860

aaaaaagaag aagaggtgaa aaaaacatta gaacagcatg acaatattgt gactcactac     1920

aaaaatatga ttcgagagca ggatctccaa cttgaggaat taaggcagca ggtttctaca     1980

ttaaaatgtc aaaatgaaca gctccagacg gcagtcacac agcaagtatc acagatccag     2040

cagcacaaag accagtataa tcttcttaaa atacagctag gaaaagacaa tcagcatcaa     2100

ggttcttaca gtgagggggc tcagatgaat ggcattcagc cagaagaaat tggtagattg     2160

cgagaagaga tagaagaatt aaaacgtaat caggaacttt tacaaagcca gctgactgaa     2220

aaggactcta tgattgaaaa tatgaaatct tcccaaacat ctggcacaaa tgaacagtct     2280

tcagcaatag tttcagctag agattctgaa caagttgcag aattaaaaca ggaactggca     2340

actttaaagt ctcagttaaa ctcacaatct gtggagatca ccaaactaca gacagaaaag     2400

caggaactgt tacagaaaac agaagcgttt gcaaaatcag ttgaggtaca aggagagacc     2460

gagactataa tagccaccaa aactactgat gtagaaggaa gactgtcagc attattacaa     2520

gagaccaaag agttaaagaa tgaaattaaa gctctgtctg aggaaagaac tgccattaaa     2580

gagcagctgg attcatctaa tagtaccatt gccattttac aaactgagaa agacaaacta     2640

gagttggaaa ttacagattc taaaaaagaa caagatgatc tcttggtgct cttggccgat     2700

caagatcaga aaatactgtc attgaagaat aaactcaagg atcttggtca tccagttgaa     2760

gaagaggatg aacttgaatc tggagaccaa gaggatgagg atgatgaaag tgaagatcct     2820

ggcaaggatc tagatcatat ctag                                            2844


<210> 3961
<211> 1642
<212> DNA
<213> Homo sapiens

<400> 3961
agagcactgc tgcggccgcc gccattttag cgttttgtca gaagcgtccg cgccgcgagg       60

aggaggccct gctggtttct gtgcgggctc ttgtcaggat ggtgaagctg ttcatcggaa      120

acctgccccg ggaggctaca gagcaggaga ttcgctcact cttcgagcag tatgggaagg      180

tgctggaatg tgacatcatt aagaattacg gctttgtgca catagaagac aagacggcag      240

ctgaggatgc catacgcaac ctgcaccatt acaagcttca tggggtgaac atcaacgtgg      300

aagccagcaa gaataagagc aaaacctcaa caaagttgca tgtgggcaac atcagtccca      360

cctgcaccaa taaggagctt cgagccaagt ttgaggagta tggtccggtc atcgaatgtg      420

acatcgtgaa agattatgcc ttcgtacaca tggagcgggc agaggatgca gtggaggcca      480

tcaggggcct tgataacaca gagtttcaag gcaaacgaat gcacgtgcag ttgtccacca      540

gccggcttag gactgcgccc gggatgggag accagagcgg ctgctatcgg tgcgggaaag      600

aggggcactg gtccaaagag tgtccgatag atcgttcagg ccgcgtggca gacttgaccg      660

agcaatataa tgagcaatac ggagcagtgc gtacgcctta caccatgagc tatggggatt      720

cattgtatta caacaacgcg tacggagcgc tcgatgccta ctacaagcgc tgccgtgctg      780

cccggtccta tgaggcagtg gcagctgcag ctgcctccgt gtataattac gcagagcaga      840

ccctgtccca gctgccacaa gtccagaata cagccatggc cagtcacctc acctccacct      900

ctctcgatcc ctacgataga cacctgttgc cgacctcagg agctgctgcc acagctgctg      960

ctgcagcagc agccgctgct gctgttactg cagcttccac ttcatattac gggcgggatc     1020

ggagccccct gcgtcgcgct acagccccag tccccactgt tggagagggc tacggttacg     1080

ggcatgagag tgagttgtcc caagcttcag cagccgcgcg gaattctctg tacgacatgg     1140

cccggtatga gcgggagcag tatgccgatc gggcgcggta ctcagccttt taaagcttga     1200

ggtgggatgt gtgtgggctg aaattccgag ctgcggttgt gcatgagaat acacccttcg     1260

tggtacccca tctccgggac gttctcggct ctgtgcgttc agtccctcag gaaccgtgga     1320

ccttaattta ccttgctaag ttcagacctt ctcttccttt cctttccttt cctctcctgc     1380

ccattttcct gttcttctgt ccttcaatac ttctgtagct tcccattcat gttctcttct     1440

cccagcaggc ctcattgtgt gcagaaactg tggtgggggc tgtgctgtct cctccctgcc     1500

tcctgcctcc tgcggctgtt ggatttggga atgaccttgg tgagagtctc actgctccag     1560

ggtctctttt tggtccaaag gctagaccta tagagttgga tcactttttt tctttccggt     1620

gaaataaatg gtttttcaac tt                                              1642


<210> 3962
<211> 1339
<212> DNA
<213> Homo sapiens

<400> 3962
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct      540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaata gataccgaga      600

tattcttcca tatgattcaa cacgcgttcc tcttggaaaa agcaaggact acatcaatgc      660

tagttatatt agaatagtca attgtggaga agagtatttt tatatcgcta ctcaaggacc      720

actgctgagc accatagatg acttttggca aatggtgttg gaaaataatt caaatgttat      780

tgccatgata accagagaga tagaaggtgg aattatcaaa tgctaccatt actggcccat      840

ttctctgaag aagccattgg aattgaaaca cttccgtgta ttcctggaga actaccagat      900

acttcaatat ttcatcattc gaatgtttca agttgtggag aagtccacgg gaactagtca      960

ctctgtaaaa cagttgcagt tcaccaagtg gccagaccat ggcactcctg cctcagcaga     1020

tagcttcata aaatatattc gttatgcaag gaagagccac cttacaggac ccatggttgt     1080

tcactgcagt gccggcatag gccggacagg ggtgttccta tgtgtggatg tcgtgttctg     1140

tgccatcgta aagaactgtt cattcaacat catggatata gtggcccaaa tgagagaaca     1200

acgttctggc atggttcaaa cgaaggagca gtatcacttt tgttacgata ttgtgcttga     1260

agttcttcgg aaacttctga ctttggatta agaaagactt ctgttgcctc tcacttgaaa     1320

ttaccaagtg ggtttgcac                                                  1339


<210> 3963
<211> 913
<212> DNA
<213> Homo sapiens

<400> 3963
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt      120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc      180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga      240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag      300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct      360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg      420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga      480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg acgggaacta gtcactctgt      540

aaaacagttg cagttcacca agtggccaga ccatggcact cctgcctcag cagatagctt      600

cataaaatat attcgttatg caaggaagag ccaccttaca ggacccatgg ttgttcactg      660

cagtgccggc ataggccgga caggggtgtt cctatgtgtg gatgtcgtgt tctgtgccat      720

cgtaaagaac tgttcattca acatcatgga tatagtggcc caaatgagag aacaacgttc      780

tggcatggtt caaacgaagg agcagtatca cttttgttac gatattgtgc ttgaagttct      840

tcggaaactt ctgactttgg attaagaaag acttctgttg cctctcactt gaaattacca      900

agtgggtttg cac                                                         913


<210> 3964
<211> 574
<212> DNA
<213> Homo sapiens

<400> 3964
atctgtacaa gggagatcta gaggtctggc ccaaagggaa acttttgctg ccaccacttt       60

caaagctttc gttaaaaaaa caaaagggag ggggaaggtg gagaaacaac caaaattctg      120

tcattccaaa taaatctaag tgaactattg attttgatac aaagcaacag cctctgccac      180

actgaagaag tgagctttaa gcagagacta gaagggtatg gcatcacagc tgcaagtgtt      240

ttcgccccca tcagtgtcgt cgagtgcctt ctgcagtgcg aagaaactga aaatagagcc      300

ctctggctgg gatgtttcag gacagagtag caacgacaaa tattataccc acagcaaaac      360

cctcccagcc acacaagggc aagccaactc ctctcaccag gtagcaaatt tcaacatccc      420

tgcttacgac cagggcctcc tcctcccagc tcctgcagtg gagcatattg ttgtaacagc      480

cgctgatagc tcgggcagtg ctgctacatc aaccttccaa agcagccaga ccctgactca      540

cagaagcaac gtttctttgc ttgagccata tcaa                                  574


<210> 3965
<211> 605
<212> DNA
<213> Homo sapiens

<400> 3965
agctttgaag gtcttgcggt ggtgcgtggc gggcaggaac ccacaattcc aaatacaaac       60

ggtcggcgcg agaagcgctt ctgggcgcag gcgcctggct gtagcgactg gttgcgggag      120

gctggactct ggtgactgtg tatggttgca tatgctccgt tttcctctcc ctgtcgtgct      180

gggcctttga aaccggcttc tttgctggtg gctgcttggt gaaaaattag acgatttcaa      240

gaattggagc tgaatctgat gttaagtaat ggcaacaggt gacttaaaaa gaagcttacg      300

gaacctagaa caggtgctcc gcttgctaaa ttatcctgaa gaggtggact gtgtaggttt      360

gataaaggga gacccagcag catctttgcc catcatcagc tattctttta cctcatactc      420

accttatgta acagaactta taatggaatc caatgtagag ctcatagcaa aaaatgactt      480

gcgctttata gatgctgtct ataagcttct tcgtgatcaa tttaattata aaccaatttt      540

gacaaaaaag cagtttatcc aatgtgggtt tgcagaatgg aaaatccaaa ttgtttgtga      600

tattt                                                                  605


<210> 3966
<211> 532
<212> DNA
<213> Homo sapiens

<400> 3966
atatttgatg gttttgttgc tttgctcggg agttctcggg agtaatttaa tgccgaaggt       60

cgctgcctag tggaaataat ataatacgtc attaatatgg cgccaaaaga ttgggttctc      120

gatctgtagc gaggagggag ggaggcagcc gctgagcgca gcgttactat cccaccagta      180

acttgggcat tgccggggcg ggggccggag gaggaggaga ggatgatttt tggatcctga      240

gaattgatct atgttggatc agtaagtttt attatgattt tttttttcaa atttgggggg      300

ctgaagactt agagctattt cttcttttgg atttgcgaag aacatgcggt tttcagttca      360

tagccctgat gaagcaagtt actctgctct cctaataaat gcaagaaaat gaccttggag      420

ggccttttta attacacata gaagtgacaa tttgctgcct gctgtttccc ggggagatca      480

tgaaacgagg tcgccttccc agcagcagtg aggattctga cgacaatggc ag              532


<210> 3967
<211> 1697
<212> DNA
<213> Homo sapiens

<400> 3967
gcagaagtcc ggggctggca agcgcttcct gcgcagcgcc taggcgacct ggagtttgtg       60

acgctgtgat ggtctagagg ctggagattc aagatctggg tgccatcatt ttctggttct      120

gttgatgacc ctcttccagt ttttcttata aggctaaaaa ttcacaaagc atatatcaat      180

gaatcaggag gatctagatc cggatagtac tacagatgtg ggagatgtta caaatactga      240

agaagaactt attagagaat gtgaagaaat gtggaaagat atggaagaat gtcagaataa      300

attatcactt attggaactg aaacactcac cgattcaaat gctcagctat cattgttaat      360

tatgcaagta aaatgtttaa ccgctgaact cagtcaatgg cagaaaaaaa cacctgaaac      420

aattcccttg actgaagacg ttctcataac attaggaaaa gaagagttcc aaaagctgag      480

acaagatctt gaaatggtac tgtccactaa ggagtcaaag aatgaaaagt taaaggaaga      540

cttagaaagg gaacaacggt ggttggatga acagcaacag ataatggaat ctcttaatgt      600

actacacagt gaattgaaaa ataaggttga aacattttct gaatcaagaa tctttaatga      660

actgaaaact aaaatgctta atataaaaga atataaggag aaactcttga gtaccttggg      720

cgagtttcta gaagaccatt ttcctctgcc tgatagaagt gttaaaaaga aaaagaaaaa      780

cattcaagaa tcatctgtaa acctgataac actgcatgaa atgttagaga ttcttataaa      840

tagattattt gatgttccac atgatccata tgtcaaaatt agtgattcct tttggccacc      900

ttatgttgag ctgctgctgc gtaatggaat tgccttgaga catccagaag atccaacccg      960

aataagatta gaagctttcc atcagtaaaa ggatgttttc ttttttcaca cagtaaaaat     1020

tcttatcatt caaggatatt ggaaccacag gactatttgg ataaaaaaca ttatttgcaa     1080

attaatgcgc ataggccatc ttacttttat tgcaaaatgg catgtgctgc catctattat     1140

tcatttttaa atggtcattt cttattcagt gagtgcttta gtgttttaaa ctatatggat     1200

aagaatgcag gtagataata ttctaggcat aaaacattta atgtacctta cctcatgcaa     1260

tattctttgg attctttgtt gatttatgat attgctaata taatattttc ttaaaatata     1320

taacaatatc ttttatgcat tttgagttcc agctggtgct tctttatatt tagaaattat     1380

aatgggaagg tcatttaatt tacagatggt tttaaaattg aggtaatatc tgaggtggca     1440

taatttaaaa atatttagca aatttgtttc atatatactg tcttatttct agatttgttt     1500

aaaattggaa tatgaaaaac taatggataa agctagcata aaattgatat tttagtttgt     1560

attattaata tatcatgtta ccttatatat taatctactc ttgattctgc taattattac     1620

caacaaaatt gtattcatga cattttatta atcctctgtg aattttctgt aaataaaatt     1680

atttctgaaa atctcta                                                    1697


<210> 3968
<211> 653
<212> DNA
<213> Homo sapiens

<400> 3968
tttcctgccg taagtataca gtgcctccgg gtcgcggtca ttttgagccc ctgtctggat       60

gacttcttgc ggctgttcta cccctccccc tccccgcgtc gcctgctgct gtcgtcggga      120

ggtgggtgag gtgacgcaaa cagccccgtt gttgccctcc gcgtatcccc tcaccacctt      180

tgcggccatc cacgactttc gcaccttccg ccattttcct gcctgtgagg gtggacagat      240

cgcgctcggg tctcggcctc ctgagtgccg gaaagatgaa tgggagggct gattttcgag      300

agccgaatgc agaggttcca agaccaattc cccacatagg gcctgattac attccaacag      360

aggaagaaag gagagtcttc gcagaatgca atgatgaaag cttctggttc agatctgtgc      420

ctttggctgc aacaagtatg ttgattactc aaggattaat tagtaaagga atactttcaa      480

gtcatcccaa atatggttcc atccctaaac ttatacttgc ttgtatcatg ggatactttg      540

ctggaaaact ttcttatgtg aaaacttgcc aagagaaatt caagaaactt gaaaattccc      600

cccttggaga agctttacga tcaggacaag cacgacgatc ttcaccacct ggg             653


<210> 3969
<211> 1305
<212> DNA
<213> Homo sapiens

<400> 3969
aaaagcgacc ttttctgagc gcgtttgcct gttgagtggt agcctttccc ctcaaccagc       60

aatggaggag cagccccaga tgcaagacgc cgacgagccc gcggactccg gaggggaagg      120

ccgggcaggc gggccaccgc aggtcgccgg cgcccaggcg gcgtgcagcg aggaccgcat      180

gaccctgctc ctcaggctga gagcacagac aaaacaacaa ctcttagaat ataaatcaat      240

ggttgatgca agtgaagaaa aaactccaga acaaattatg caagaaaagc aaatcgaagc      300

taaaattgaa gacctggaaa atgaaattga agaggtaaaa gttgcttttg agataaaaaa      360

gcttgcatta gacagtgtgc tcatggataa catgaaacac ctattagagc taaataaatt      420

aataatgaaa tcacagcagg aatcttggga tttagaggaa aaactgcttg atattagaaa      480

gaagagattg caattaaaac aagcttcaga aagtaagctt ttagaaatac agactgaaaa      540

gaacaaacag aagattgatt tggacagtat ggaaaactca gagaggataa agatcatacg      600

acaaaaccta cagatggaga taaaaattac tactgttatt caacatgtgt tccagaacct      660

tattttgggg agtaaagtca attgggcaga ggatcctgcc cttaaggaaa ttgttctgca      720

gcttgagaag aatgttgaca tgatgtaata agaattcatt tctgacatat tttacatttc      780

tggcaatctc aactcttatt tggaatactt ctgtgcattt gtctgtccac cgtaatttta      840

gaaaagcata tccataacgt ttacagttgt agtacagttg tggttagtta tttgtagtgg      900

gattgaaagt aatttttttc tttttatatt tctatattta gtttgttttt ttgttgttgt      960

tgttttttga gatggagtct cgctttgttg cccagactgg agggcagtgg cgcgatctcg     1020

gctcactgca acctctgcct cccgggttca agcagttctg cctcagcctc ccaagtagct     1080

gtgactaaag gtgcacgccg ccatgcccag ctaatttttt gtattttagt agagacgggg     1140

tttcaccgtg ttgcccaggc tgctctcaga actcctgagc tcaggcagtc caccgcctcg     1200

gcctaccgaa gtgctaggat tacagacgta agccaccgag cctggtctag tttgcatttt     1260

ttttctatca gttttataag ttaagaaata aaaggaatta atgtt                     1305


<210> 3970
<211> 2578
<212> DNA
<213> Homo sapiens

<400> 3970
cttttgtctc tcagctattt tttgttccct atgtttgtag gatggaaagg cagatgtaaa       60

gtccctcatg gcgaaatata acacgggggg caacccgaca gaggatgtct cagtcaatag      120

ccgacccttc agagtcacag ggccaaactc atcttcagga atacaagcaa gaaagaactt      180

attcaacaac caaggaaatg ccagccctcc tgcaggaccc agcaatgtac ctaagtttgg      240

gtccccaaag ccacctgtgg cagtcaaacc ttcttctgag gaaaagcctg acaaggaacc      300

caagcccccg tttctaaagc ccactggagc aggccaaaga ttcggaacac cagccagctt      360

gaccaccaga gaccccgagg cgaaagtggg atttctgaaa cctgtaggcc ccaagcccat      420

caacttgccc aaagaagatt ccaaacctac atttccctgg cctcctggaa acaagccatc      480

tcttcacagt gtaaaccaag accatgactt aaagccacta ggcccgaaat ctgggcctac      540

tcctccaacc tcagaaaatg aacagaagca agcgtttccc aaattgactg gggttaaagg      600

gaaatttatg tcagcatcac aagatcttga acccaagccc ctcttcccca aacccgcctt      660

tggccagaag ccgcccctaa gtaccgagaa ctcccatgaa gacgaaagcc ccatgaagaa      720

tgtgtcttca tcaaaagggt ccccagctcc cctgggagtc aggtccaaaa gcggcccttt      780

aaaaccagca agggaagact cagaaaataa agaccatgca ggggagattt caagtttgcc      840

ctttcctgga gtggttttga aacctgctgc gagcagggga ggcccaggtc tctccaaaaa      900

tggtgaagaa aaaaaggaag ataggaagat agatgctgct aagaacacct tccagagcaa      960

aataaatcag gaagagttgg cctcagggac tcctcctgcc aggttcccta aggccccttc     1020

taagctgaca gtgggggggc catggggcca aagtcaggaa aaggaaaagg gagacaagaa     1080

ttcagccacc ccgaaacaga agccattgcc tcccttgttt accttgggtc cacctccacc     1140

aaaacccaac agaccaccaa atgttgacct gacgaaattc cacaaaacct cttctggaaa     1200

cagtactagc aaaggccaga cgtcttactc aacaacttcc ctgccaccac ctccaccatc     1260

ccatccggcc agccaaccac cattgccagc atctcaccca tcacaaccac cagtcccaag     1320

cctacctccc agaaacatta aacctccgtt tgacctaaaa agccctgtca atgaagacaa     1380

tcaagatggt gtcacgcact ctgatggtgc tggaaatcta gatgaggaac aagacagtga     1440

aggagaaaca tatgaagaca tagaagcatc caaagaaaga gagaagaaaa gggaaaagga     1500

agaaaagaag aggttagagc tggagaaaaa ggaacagaaa gagaaagaaa agaaagaaca     1560

agaaataaag aagaaattta aactaacagg ccctattcaa gtcatccatc ttgcaaaagc     1620

ttgttgtgat gtcaaaggag gaaagaatga actgagcttc aagcaaggag agcaaattga     1680

aatcatccgc atcacagaca acccagaagg aaaatggttg ggcagaacag caaggggttc     1740

atatggctat attaaaacaa ctgctgtaga gattgactat gattctttga aactgaaaaa     1800

agactctctt ggtgcccctt caagacctat tgaagatgac caagaagtat atgatgatgt     1860

tgcagagcag gatgatatta gcagccacag tcagagtgga agtggaggga tattccctcc     1920

accaccagat gatgacattt atgatgggat tgaagaggaa gatgctgatg atggtttccc     1980

tgctcctcct aaacaattgg acatgggaga tgaagtttac gatgatgtgg atacctctga     2040

tttccctgtt tcatcagcag agatgagtca aggaactaat gttggaaaag ctaagacaga     2100

agaaaaggac cttaagaagc taaaaaagca ggaaaaagaa gaaaaagact tcaggaaaaa     2160

atttaaatat gatggtgaaa ttagagtcct atattcaact aaagttacaa cttccataac     2220

ttctaaaaag tggggaacca gagatctaca ggtaaaacct ggtgaatctc tagaagttat     2280

acaaaccaca gatgacacaa aagttctctg cagaaatgaa gaagggaaat atggttatgt     2340

ccttcggagt tacctagcgg acaatgatgg agagatctat gatgatattg ctgatggctg     2400

catctatgac aatgactagc actcaacttt ggtcattctg ctgtgttcat taggtgccaa     2460

tgtgaagtct ggattttaat tggcatgtta ttgggtatca agaaaattaa tgcacaaaac     2520

cacttattat catttgttat gaaatcccaa ttatctttac aaagtgttta aagtttga       2578


<210> 3971
<211> 850
<212> DNA
<213> Homo sapiens

<400> 3971
agggacctta tttaggttgc gcaggcgccc gctggccatt tcgtcttagc cacgcagaag       60

tcgcgtgtct aggtgagtcg cggtgggtcc tcgcttgcag ttcagcgacc acggtgggta      120

ccgtttttgc gaggattgtt tgtccccata tctctgggag ggccacgggg accttggcga      180

gctgcaggct gccgtcgaga gccgcgagtg gttcgctgaa tctcggcacc gccgctgagg      240

cctgcaggcc gcgccgactc tattgtgtga gaagtcggag gaggcggagc ggaagcggcc      300

gccgccattt cctttcctct acgctggctc tcggcccggg cccccacggt tcggggcgcc      360

gacagctgtt gctcaggaca gctttggggg tccggtcgcc ggacgaggag gtgttggagt      420

cgccgggttt gtttcgacgc cggaccgcgt aagagacgat gatgttgggc acggaaggtg      480

gagagggatt cgtggtgaag gtccggggct tgccctggtc ttgctcggcc gatgaagtgc      540

agaggttttt ttctgactgc aaaattcaaa atggggctca aggtattcgt ttcatctaca      600

ccagagaagg cagaccaagt ggcgaggctt ttgttgaact tgaatcagaa gatgaagtca      660

aattggccct gaaaaaagac agagaaacta tgggacacag atatgttgaa gtattcaagt      720

caaacaacgt tgaaatggat tgggtgttga agcatactgg tccaaatagt cctgacacgg      780

ccaatgatgg ctttgtacgg cttagaggac ttccctttgg atgtagcaag gaagaaattg      840

ttcagttctt                                                             850


<210> 3972
<211> 552
<212> DNA
<213> Homo sapiens

<400> 3972
ctcgcgggaa ctgcattcaa atatcccagg cgcttactcg agagctagct gagcgaatgg       60

gccggcgact gtggagttag cgtcctcaat gtggacgccc tgagctccca ttaggagccg      120

ctggctgcgg cagcagggga ctagcgtgag agaatggaac ctagtatata aggcattcaa      180

gaaatactcg ttcagtgaat gactacattg acttgagaca tgggggaaca tcttgcaatg      240

acctggtgcc ctttgaaggc aaagttggct aaaaaaaaga aaagaacatg gaggcagata      300

taatcacaaa tcttcgatgc aggctcaaag aggctgaaga agagcgacta aaagctgcac      360

agtatggttt acaactagta gagagtcaaa atgaattaca gaatcaattg gataaatgtc      420

gtaatgaaat gatgaccatg actgagagtt atgaacaaga aaaatatacc cttcaaagag      480

aagttgaact caagagtcga atgttagaaa gtttgagctg cgaatgtgaa gctattaaac      540

aacaacaaaa aa                                                          552


<210> 3973
<211> 4273
<212> DNA
<213> Homo sapiens

<400> 3973
atgacggccg gcgcgagtat tttccacata aggtggctgt cgtttttctc ctggcgtctg       60

tggaggcgag tggtctgcgg gcagcagctc ccagaggcag ccttggaatt ccagctcgga      120

ctgggcggga aggcgcaggc ggcccaggtc gccgacacgc tcacgcaccc tccctgcctg      180

gccgcgcctc tgcgaccagg tgacccaatg aaagaagaaa atgaaagcca taaagaaaag      240

tcttacagaa gaagaatacc tgtacctgga cttttctcac caaacagaag gatgcatctt      300

tcctcttcat acatctgtaa ctttatttct gttatcttac tgtgactgta aaatctttaa      360

aatttgctta gttgtcacca aagaggtgag tagagatagt tcactactaa gagatgacct      420

gatccaggat gttgaaatac agattatttc aaggcaggag ctcccaccaa tagtccaaaa      480

ttgctgtttg cctgcagtag tagaacgatc agacaatttt tgtagagcag gacttgctgt      540

tgtattgaga cacataatcc agaaatccta tgaagcagac cccttaaaga aggaactttt      600

ggaacttctg ggctttaaaa agacttgctt gaaagcctgt gctgaagtta gtcagtggac      660

caggctatgt gaactcacca tccctttggc tattgagaat tttctcagag aatcttctga      720

ccagccccca actatacctg tagaaatact acagctagag aaaaagctta gtgagcctgt      780

tagagtgcat aatgatgata aactccgcag gcagaagctc aagcaacaga aggctgatgg      840

agttgggcct ccccttacta agggaaaggc aaagagcaag gtccacacac aggaaacatc      900

tgaagggttg gattcttcat ccaagagtct ggaactgaaa gtggcattct caaagctcac      960

agtacaggaa gaaccagcta ctaccaacag agagccttct cacatcagaa aagcaaaagc     1020

ctccgacctt ccacctctgg agcatgtgtt tgcagaaggg ctttacttca ctctggcaga     1080

tattgtgctc ttgccctgta tccatcattt cttggtaatt atcagcagga aattttctga     1140

gaagctggta gaatttccat tgctagcctc ttggtaccag aggattcagg aagtgccagg     1200

agtaaaaaca gcagcttcta agtgtgggat ccaatttctc catttaccaa agttgttgac     1260

aacctcaact gaacagcatc caaacttatg tgaagtccca ggtgtagaag agcaaagcga     1320

tcctttattt ataggaggac caagaccaac catggccaag ttaatggaaa agggcattga     1380

agtgatgttt tctccccacc cttgccctac ttggactctt gattggaatg ttctccctgc     1440

agcagtcagc ccaaaggaag gtaaaatgtc cagtgatcga gctttgagga agcagcaaca     1500

gttgaacaac cttgtctatg tggtaacaaa tcaggccaaa cctggtgaca gaattgtgga     1560

tttctgcagc ggtgggggcc atgttggaat tgtccttgct cacatgctgc catcatgtca     1620

ggttacatta atagaaaaca aggaattatc attaattcgt gctaagaaga gaagtgatga     1680

actgggttta agcaacattt ggttcattca agcaaatatg gaatatttta ctgggatgtt     1740

taatattgga gtagcattgc atgcttgtgg agtggcaaca gacatggtga ttgagcactg     1800

tatcaaaaca cgggcttcct tcgtcacatg cccttgctgt tatggtttca ttcagaacac     1860

ctcaaagttc aattttccaa aaagtgaaca attcaagaaa actttatcat acaaggaaca     1920

catgattctg tgcagatttg cagaccagac agctgtccag ctcccacccc aacgaaggct     1980

cataggaaaa cagtgcatgt gcttggtgga tctggatcga gcaagagctg cagaagaatg     2040

tggatactcc gttcaagtga tatccatgga gccagagagc tgctctccca aaaataacat     2100

gattgtggga gtccccattt aaaatgagat attcacattt gatattttgc catccgtctt     2160

cacgttggat gcccagtggc attcaggagg ttcttggcat aactaggaaa cagcattagc     2220

catcttgaac ctattgtgct caggaaggaa agcaacaggg aaatcttgga agtaaaggct     2280

ccctgcaaag catcacaaat gctttacaat gtgtgattaa aggactgctg gtttttatag     2340

tgagaatccc ctgaagtctc agctgccaaa agaataatac tagtggaggt tccatcacag     2400

gaataacaat ttccttctca cttcacaagc tcctctgatc ttgccaatgt gatgtttaat     2460

tcaaaacagc gcacttacag cctttatttt atacttattt agatattcac atgggaactg     2520

aaagtagact cagtggagtt ttttgttttt tatattttta acaattgtac tttttctatc     2580

actttaaaaa aatctagtca ggtaattata gtacagttat ttttaagctg gggttagttg     2640

aacttgtata gcatttaata tactcctttt aaatatattt ctgccaggca tggtggctca     2700

tgcctataat cccagcactt tgagaggcca aggtgggagg atcatttgag cccaggatat     2760

cgagaccagc ctgcactaca aaaaaatcca aaaaatgagg tgggaggatc acttgagccc     2820

aggaagtcaa ggctgcagtg agccttgata gcgccactgc actcctgcct gggaaaatga     2880

gacccagact caaaataaat caatgaatga attaataaac aaataaataa ataaataaat     2940

ttcccataaa ttaccaaatg agattgtcac tggttcaaat tattaaataa ttgccataaa     3000

tttcctatta cgggaatgtg gaatttggac atacatttta acaataagta cattgattaa     3060

tacatttaag tttataagta attattgagg atccagtatt ttcaagacct tggcctagtt     3120

tcttttcaat tcaaagatga gttgcaaaag acataatgtt ttgcctatgg aagtagatca     3180

tctagaagaa aaagattaaa gaattagtta agcttttttt tttttttttt tttgagacag     3240

agtttcactc ttgttgccca ggctggaatt cagtggctcg atcttggctc accacaacct     3300

ctgcattctc ctgcctcagc ctcccgagta gctaggatta taggcacctg ccaccatgcc     3360

cggctaattt tgtttgtaat tttagtagag atggggtttc tccatgttgg ccaggctggt     3420

ttcgaactcc tgacctcagg tgatctaccc gcctcagcct cccaaagtgc tgaaattaca     3480

ggcgtgagcc acctcacctg gccatgttct ttatggaata ctacaatgtg ttgtcacagg     3540

atttgttatt cagatgtcaa tcatttttat ttatatattt ctgggtaaaa cttattagtg     3600

gtgtgaggag tgcagaatat ggaagcttac ctaaattctt tttctgccag ccaacatttt     3660

aaaagacaaa tgatgcatcc tttctcaatg ctgctaattc tttaaatttt acatgtccca     3720

atttattcca tttgagattt attttaatgt tttcaacccc tgtgtaacat gtatcatgag     3780

gagaaagcac tatcattgat catcactatg gattaaaata taggaatatt ttacagggca     3840

gtatgggtgg gggtgggaga catattggaa tcgtgttttc tgggataaaa tttttaaaaa     3900

gaattaatca ttagccctga gtattttagt catttgtgcc tatagaaaac aacatgctct     3960

tttattgtgg actttcttct tttaagtgag gtttaattta tatacaatac aataacagat     4020

ttttaagtat tcatttgaga tgttttgaca actgtatata tacatgtaac catcactgga     4080

atcagatata gaatattccc cttaaatatt gtcaggtaaa cacattgaga atattttttc     4140

cagtctgtgg cttacctact tattttcata atgaatgttt tacttgtgat gaagatttaa     4200

cttacccttt tactttaatg attaatattt tctgtgttct ttctaataaa ttttacgaac     4260

tctgaggtta taa                                                        4273


<210> 3974
<211> 913
<212> DNA
<213> Homo sapiens

<400> 3974
ttccaaatac aaacggtcgg cgcgagaagc gcttctgggc gcaggcgcct ggctgtagcg       60

actggttgcg ggaggctgga ctctggtgac tgtgtatggt tgcatatgct ccgttttcct      120

ctccctgtcg tgctgggcct ttgaaaccgg cttctttgct ggtggctgct tgaagcatca      180

agtgtacctg atttgtgaac ctatcttgct tcagttggtt tcctcctaaa tattaggcag      240

atgggattgg ctggtctgtg ctctgctagg tgaaaaatta gacgatttca agaattggag      300

ctgaatctga tgttaagtaa tggcaacagg tgacttaaaa agaagcttac ggaacctaga      360

acaggtgctc cgcttgctaa attatcctga agaggtggac tgtgtaggtt tgataaaggg      420

agacccagca gcatctttgc ccatcatcag ctattctttt acctcatact caccttatgt      480

aacagaactt ataatggaat ccaatgtaga gctcatagca aaaaatgact tgcgctttat      540

agatgctgtc tataagcttc ttcgtgatca atttaattat aaaccaattt tgacaaaaaa      600

gcagtttatc caatgtgggt ttgcagaatg gaaaatccaa attgtttgtg atattttgaa      660

ttgtgtgatg aaaaagcaca aggaattaag cagtcttcag aagattccat cacaacaaag      720

aaagaaaatc agttctggta agtcagaacc tcctttgggc aatgagaaaa tatctgcaga      780

ggctgttggc gttgatatca gtggcaggtt tatgacctca ggaaagaaga aagctgtggt      840

gattcgtcac ttgtataatg aagataatgt tgacatttct gaggatacat taagtccaat      900

aacagatgtt aat                                                         913


<210> 3975
<211> 560
<212> DNA
<213> Homo sapiens

<400> 3975
gcagcgcctg gcgcccggga agaggtggtt gtgaggcaga cgaactcgcg gctctccggc       60

ttccgaggct tccgagttgt cggaggaagg gggcggcgag caataagaac ccgccgcacc      120

cggtcctcag cgactcttct gacctccgcg cgacgtaccc gccgccgccg ttggctggag      180

ttattcttgt gtttgctccc tcagcatttg acattgtgca gcaaagaaat ggttatggag      240

aagcccagtc cgctgcttgt agggcgggag tttgtgaggc aatattatac tttgctgaat      300

aaagctccgg aatatttaca caggttttat ggcaggaatt cttcctatgt tcatggtgga      360

gtagatgcta gtggaaagcc ccaggaagct gtttatggcc aaaatgatat acaccacaaa      420

gtattatctc tgaacttcag tgaatgtcat actaaaattc gtcatgtgga tgctcatgca      480

accttgagtg atggagtagt tgtccaggtc atgggtttgc tgtctaacag tggacaacca      540

gaaagaaagt ttatgcaaac                                                  560


<210> 3976
<211> 945
<212> DNA
<213> Homo sapiens

<400> 3976
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat       60

tggtgaacaa aaattgtttg ctggccccca ggatactaac tagacctttg gcctgactca      120

caggacacta aggctccttt tctgaagaag ccttttacca gtctcattta ggggatggga      180

acaacatgtc ttcacctagg gactttagag cagagcctgt aaacgattat gagggaaatg      240

actctgaagc agaagacttg aatttcaggg agactttgcc ttcatcaagt caggaaaaca      300

cacctagatc aaaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc      360

ggaatttccc acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg      420

atcccagcat gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg      480

aggaggctgc agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg      540

tttctgaagg agaactagat cagttggctc agattcggcc attaatattc aattttcatg      600

agcagacagc catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata      660

tcatgcagga atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga      720

atcaaccaag caacagagaa aaaaatagat accgagatat tcttccattt caacatcatg      780

gatatagtgg cccaaatgag agaacaacgt tctggcatgg ttcaaacgaa ggagcagtat      840

cacttttgtt acgatattgt gcttgaagtt cttcggaaac ttctgacttt ggattaagaa      900

agacttctgt tgcctctcac ttgaaattac caagtgggtt tgcac                      945


<210> 3977
<211> 2044
<212> DNA
<213> Homo sapiens

<400> 3977
ttattagccc ctcctcctcg ctcggtccag gaccggctct gcgggcgccg ccaggcccag       60

accaagctac tatcagaagt tgaattctaa taattagcta ttttataaag gtaacgagaa      120

aaaatacact atgtctgatg aagtttttag caccactttg gcatatacaa agagtccaaa      180

agttaccaaa agaactactt tccaggatga gctaataaga gcaattacag ctcgctcagc      240

cagacaaagg agttctgaat actcagatga ctttgacagt gatgagattg tttctttagg      300

tgatttttct gacacttcag cagatgaaaa ttcagttaat aaaaaaatga atgactttca      360

tatatcagat gatgaagaaa agaatccttc aaaactattg tttttgaaaa ccaataaatc      420

aaacggtaac ataaccaaag atgagccagt gtgtgccatc aaaaatgaag aggaaatggc      480

acctgatggg tgtgaagaca ttgttgtaaa atctttctct gaatctcaaa ataaggatga      540

ggaatttgaa aaagacaaaa taaaaatgaa acctaaaccc agaattcttt caattaaaag      600

cacatcttca gcagaaaaca acagccttga cacagatgat cactttaaac catcacctcg      660

gccaaggagt atgttgaaaa agaaaagtca catggaggag aaggatggac tagaagataa      720

agaaactgcc ctcagtgaag aattggagtt acattctgca ccttcttccc ttccaacgcc      780

gaatggcata caattagaag ctgagaaaaa agcattctct gaaaaccttg atcctgagga      840

ttcatgctta acaagtctag catcatcatc acttaaacaa attcttggag attctttttc      900

accaggatct gagggaaacg catctggaaa agcagaccat gtgactactg cagttgagaa      960

atccaaggaa agtcaagtga ctgctgatga ccttgaagaa gaaaaggcaa aagcggaact     1020

gattatggat gatgacagaa cagttgatcc actactatct aaatctcaga gtatcttaat     1080

atctaccagt gcaacagcat cttcaaagaa aacaattgaa gatagaaata taaagaataa     1140

aaagtcaaca aataatagag catccagtgc atctgccaga ttaatgacct ctgagttttt     1200

gaagaaatct agttctaaaa ggagaactcc atcgacaact acctcttctc actatttagg     1260

gactttaaaa gtcttggacc aaaaaccttc acagaaacag agcatagaac ctgatagagc     1320

agataacata agggcagctg tttatcagga gtggttagaa aagaaaaatg tgtatttaca     1380

tgaaatgcac agaataaaaa gaattgaaag tgaaaactta aggatccaaa atgaacagaa     1440

aaaagctgct aaaagagaag aagcattagc atcatttgag gcctggaagg ctatgaaaga     1500

aaaggaagca aagaaaatag ctgccaaaaa gaggcttgaa gaaaaaaaca agaagaaaac     1560

tgaagaagaa aatgctgcaa gaaaaggaga agcactacaa gcttttgaaa aatggaaaga     1620

gaaaaagatg gaatatctta aagagaaaaa tagaaaggag agagaatatg aaagagcaaa     1680

gaaacagaaa gaggaggaaa ctgttgccga gaaaaagaaa gataatttaa ctgctgttga     1740

gaaatggaat gaaaaaaagg aagctttttt caagcaaaag gaaaaagaaa aaataaatga     1800

gaaaagaaag gaagaactga aaagagctga gaaaaaagat aaagataaac aagctattaa     1860

tgaatatgaa aaatggctgg aaaataagga aaaacaagaa agaattgaac gaaaacagaa     1920

gaaacgtcat tcctttcttg aaagtgaggc acttcctccg tggagccctc caagcagaac     1980

tgtgttcgca aaagtgtttt gataattcta gttcttacat tatttggtta tttatcggtt     2040

tgcc                                                                  2044


<210> 3978
<211> 690
<212> DNA
<213> Homo sapiens

<400> 3978
acgcctggtg aatggacgca ctcttaccaa ttctgctctg ggagatgcag cggtaaccta       60

ccgagcgcag aggccggcgc gcacccgtgg agcccgcgct cgcgatccct cctcgtgcca      120

gggccccagg gcagtcaagg cctgccgacc gttaggcggg tcaaggggta cacagggtgc      180

gaattcgtta ggcaaaagct gggtacaggc gcgagccaca ggcacggaaa cctcgcgccg      240

accggggccc taggcccgac gacggcaggt cggccaggag cgcgccggta agagcctggg      300

ggcaaggggt agaaagacgc ccacctcatc acaacccaga gctcgggact cctatacagt      360

cccataggga acaggcggcc gccattcccc tcccccacgc tggcggtttg tttcgacgcc      420

ggaccgcgta agagacgatg atgttgggca cggaaggtgg agagggattc gtggtgaagg      480

tccggggctt gccctggtct tgctcggccg atgaagtgca gaggtttttt tctgactgca      540

aaattcaaaa tggggctcaa ggtattcgtt tcatctacac cagagaaggc agaccaagtg      600

gcgaggcttt tgttgaactt gaatcagaag atgaagtcaa attggccctg aaaaaagaca      660

gagaaactat gggacacaga tatgttgaag                                       690


<210> 3979
<211> 4113
<212> DNA
<213> Homo sapiens

<400> 3979
gcactctagc ctgggtgaca gagtgagact ccgtctcaaa aatatgcact gctgatctgt       60

taatagagtt atggaatcat tgagctaaat gaagtttgca tatgaacaaa tgaatgaatt      120

ggctacaaat tgatatgatt tatagaaact ctgttcgaaa gtattgggga cttgatgttt      180

aaacattatt ttagtaaaaa ttcctataac catgtatcat ctgtaggatt gatttggtac      240

ctatttctcc tgttggacca tgagttcctc cagagcagag cttttgtctt agactatttt      300

atttctattt ctatttcttt tttttctttc tttttttttt tttttttgag acagtctctt      360

gctctgtcac ccaggctgga atgcagtggc atgatctcgg ctcactgcaa cctctgcctg      420

cagggttcaa atgattctcc tgcttcagcc tccccagtag ctgggacagg cgcatgccac      480

cgtacccggc taatttttgt atctttagta gagacagggt gttggtcaga ctggtcttga      540

actcctgacc ttgtgatccg cccacctcgg cctcccaaag tgctgggatt acagatgtga      600

gccaccatgc ccagcctaga ctgttttatt tcttaagcac tgttttccta atttcttaag      660

cactgagctc ccttaaaatt cagcaaatgt ttgttaatga tgatgaatat tttactaatt      720

tctttaaaaa catattttca attgaagttg caaaaccttg gaacctctta atttatatct      780

tgcataaatg acaatttgtt aaagttaaga tacattgctg tggaaatcta tgtatttctt      840

tactgcaaaa tagtattaaa ggaaactaaa tgaatttcaa gaatatgagc tttataattt      900

aatttttagg attcgctaaa tattgtaatg gatcaaggag atacacctac actagaggaa      960

gatttgaaga aacttcagct ctctgaattc tttgatatct ttgagaagga gaaagtagat     1020

aaggaagctc tggctttatg tacagaccga gatcttcagg aaataggaat tcctttagga     1080

ccaagaaaga agatattaaa ctatttcagc accagaaaaa actcaatggg tattaagaga     1140

ccagccccgc agcctgcttc aggggcaaac atccccaaag aatctgagtt ctgcagtagc     1200

agtaatacta gaaatggtga ctatctggat gttggcattg ggcaggtgtc tgtgaaatac     1260

ccccggctca tctataaacc agagatattc tttgcctttg gatctcccat tggaatgttc     1320

cttactgtcc gaggactaaa aagaattgat cccaactaca gatttccaac gtgcaaaggt     1380

ttcttcaata tttatcaccc ttttgatcct gtggcctata ggattgaacc aatggtggtc     1440

ccaggagtgg aatttgagcc aatgctgatc ccacatcata aaggcaggaa gcggatgcac     1500

ttagaactga gagagggctt gaccaggatg agtatggacc ttaagaacaa cttgctaggt     1560

tcgctgcgga tggcctggaa gtcttttacc agagctccat accctgcctt acaagcttca     1620

gaaacaccag aagaaactga agcagaacct gaatcaactt cagagaagcc tagtgatgtt     1680

aacacagaag agacctctgt ggcagttaaa gaagaagtcc tgcctatcaa tgtggggatg     1740

ctgaatggag gccaacgcat tgactatgtg ctacaggaga agcctattga aagttttaat     1800

gagtatttat ttgctttaca aagccatcta tgctactggg agtctgaaga tacagtattg     1860

ctcgtcctca aagagatcta ccaaacccag ggtatcttcc ttgatcagcc tttacagtaa     1920

aaatgaccca tctatggctg cttaatacgg acattgaggg atccttcccc agaaaatcca     1980

cctgtttgtt gctgcaattt tcctctcctc agctgcgtca tttcctgcat gttgcctgcc     2040

acttactcac cactggggtc tttggaagat aatcttcctc tttggaaatg aatggaaaag     2100

caaaaggccc tattactttt aaccactggc ttcatataaa cacttgccat ttttttctgc     2160

atagctgggg gtggtttgtg tctttaattc tttgatgata gtttatagtt gccacacttt     2220

attgattagt acttgacagg gtgtaaagcc tattttgggt ttgatttgtt ttgggtgggg     2280

tagacatgtt tttaaggaac ttattgctta tctttagaaa atgttctagt ttggaaacag     2340

attcttgaga ttcagaaggc attttggagt acacttatct cttgtttgtg ttgaactgaa     2400

ggctaagtct cagtggacat ggaaaagact tttgggtgat ttatttttga acctgcattt     2460

ctttcttatg tgtagtgtat gaagaaagac tagaatgtag ctttaaaaaa gtgttgttta     2520

ctctcttaga actgacagac ttattgccag aaatcactga tgttcattgt ttttgcaact     2580

gtttgagctg ctgtaagagt ctaaagttga caagttagtt catgttaggt gcatctttat     2640

aaagcaaaga tgttgtatat cctaggcctc ccttttatat ttgatagaag ttatttgcta     2700

atagcttcta ttcttacgtt gaaaatagtt gtaaaagctg atgaacctga aattgtgtag     2760

cctctacagg ctgctgaggt tctaaataaa accttttagt ggtgccttta tggtgaaaca     2820

gaatttgtca cctgccattt ctacttgagc taaggtagta ttgtgtatcc tctttccttc     2880

ttaggtatcc ataatccaca aagcatattt aaaaggctct tggcacgggc agcattggtt     2940

gagcaggtag gtttggctag ggggaaatgt ttaacttgtt ctgaaagaaa aacttatgtc     3000

tgtagggtcc aagaaacagc tattccagag tcagtgtcag ctgagtctgg aacatatgaa     3060

gtgaggttta cttctaagaa cacaagtgac tgcacactaa ttttgtcaag gcatcttttc     3120

actactttgc tgtagatttt tcttcttcat tggtcagttt gtcattgtct ttgtagttct     3180

ctttatgata atcctttata cttgctctca gattccacag gcctctgttt atagagtggc     3240

aaaggcaggc gagctgtggt ttattgttta taaatttttt tataaatgtt atggtattca     3300

aagccactga catttaatat ttactgaagc cattccttag acagcagtgg tctttatccc     3360

tttctggaaa gaaaaggaaa atgaagggta attactgtca ccatggagat tgtagaggta     3420

aggttggggt ataggtcagg cctggccttt ctttgtcatc tgcttatagt ctagtgctaa     3480

gtatgccact aagtttcaga tatatggaat actttatttt tttaaaggta tataaactct     3540

gagttattga gaattaagta ttcactgtat attaagggga agcttttgcc aagttgtggt     3600

cttcaaattt atgtttactc ttcctattgg cagaataggt gctatttaag agtaaaccaa     3660

aggataagca gagggagtcc ctataaccaa agatggacag catagccctg gatagccaga     3720

taaaccactc tttgtattaa gaaatgtttc tttcctagtg gtgaggggtg ggtaactgtg     3780

aaagagcttt atatcttgtc tattcatggt attatagctg tatattccca ggatgataag     3840

cttgattgaa atcctgtatt tagtcatata ttatttgcgc tgcttcattt gtatcatgtg     3900

caatctctag accaacccta tttttaaact ctggtacagc atcattttgt acatattccc     3960

agctgcagaa ctagtatcac ttatctcagc aaaagagatt gtttgcatgg aaagattaat     4020

agcactgatt agatttctaa tattttgcat ttttgaaatg tttgttttct acgtgattat     4080

atttaaaact ttagtaaata ctaacatgaa acc                                  4113


<210> 3980
<211> 2771
<212> DNA
<213> Homo sapiens

<400> 3980
gaactgggcc aagcgccccc ggaggcgcta agcttgcgcc ctgaggcggt ttccgttccc       60

ggacgtttgg actctgtcct ggagaagggg aaggaaaaag taagacgtag aagtacactg      120

agacttcgtc acacataaaa caagcacgac aaagaaagag ggcgcgaagg gactcctgga      180

agaaattgag tctacattta agatcaccct aaaagtagtg acggcctctt cattactcca      240

aaccccagat ttaagtcggt aggacgtctt cgcgttgact tgtggggaat gtagtttcga      300

tgctgccggc gcgttttgtt tgcgacagaa actacaaccc ccaggggcca ccgcgacgtt      360

gcctgtgggt gcccgcgaac caacggttag cggtggcagg ggctgactga gagcgtctgc      420

ttgataatgg attctgaatt aatgcatagt atagtaggaa gctatcataa acctccagaa      480

agagtatttg ttccctcatt cacccagaat gaaccatctc agaattgcca tcctgcaaac      540

ttagaagtta cctctcctaa gatacttcat agcccaaata gccaagctct tattttagcc      600

ttaaaaactc ttcaggaaaa aattcatcgt ttagagctgg agagaacaca agctgaagat      660

aacctgaaca ttctttccag agaagcagca cagtataaga aggccttaga gaatgaaaca      720

aatgagagaa atctggcaca ccaggagctg ataaagcaga aaaaagatat aagtatacag      780

ttaagctcag cccagtctcg ttgtactctt ctagagaagc aactagaata tacaaagaga      840

atggttctca acgtagagcg agaaaagaac atgatcctag aacaacaggc ccagcttcag      900

agggaaaaag aacaagatca gatgaagctg tatgcaaaac ttgaaaagct tgatgtctta      960

gaaaaagagt gtttcagact tacaacaact cagaaaactg ctgaggacaa gattaaacat     1020

ttagaagaaa aacttaagga agaagaacat cagcgtaagc tatttcaaga caaagcttct     1080

gagcttcaaa ctggacttga aatcagtaaa attataatgt cttcagtttc aaatctaaag     1140

cactccaagg aaaagaagaa atcttcaaag aaaactaaat gtataaagag acgaccacct     1200

tggcaaattt gttcaaagtt tggagcactg ccttttgtgg ctgaaaagat gaggcaacat     1260

cgtgacccac atatccttca gaaacctttt aacgtgactg agactagatg tctccccaag     1320

ccttctagaa caacttcctg gtgtaaagct attcctcctg actcagaaaa gtccatttcc     1380

atttgtgaca atttatctga acttttgatg gcaatgcaag atgagctgga ccaaatgagc     1440

atggagcacc aagaactact gaaacaaatg aaggaaactg aaagtcattc agtctgtgac     1500

gacatagaat gtgaactaga gtgtttactc aagaaaatgg aaattaaagg agaacaaatc     1560

tccaaactga agaagcatca agacagtgtc tgtaaactgc agcaaaaagt tcaaaactca     1620

aagatgagtg aagcttcagg tattcagcaa gaagacagct accctaaagg atcaaagaac     1680

ataaaaaata gccccagaaa atgtttgact gacactaacc tttttcagaa aaacagcagc     1740

tttcatccaa tacgagttca taatcttcaa atgaaattga gaagagatga tatcatgtgg     1800

gaacagtaac aaaacagcaa aactgtcacc ttaatgaact ttgtcagtga gaccttgaat     1860

tgtctaaagt ggttttaatt taatataact ttgtgacatt ttgaatcatg tttctagttt     1920

ctataaaaca tgaagttgca gtatttaaaa attaatgcct aatgacctgg tgggttccaa     1980

ataataaatt aattgctttt ttatttttct tattgattga agcccgtaac ctcatcttgt     2040

cttagaaaca ttgttggctt tgcagatatc ttaagctaaa tttaagaaat tgtactagat     2100

tgacaatatt caaaattgag ttaaatccaa gctacaagta ccattcattc cacttttcat     2160

ttagtaggtt tggaacctta aaaaccaatg ttcaatgaac agagttcaga aagatcattt     2220

agctttcctg gtgccttctt tctattttgt tttagagctg tgaaatgttt ttctcttttg     2280

gaaaaggaaa aacttaatag ttacacagtt ttgtgaagaa gcctttaatc caagttttat     2340

gagacagtag gaacctatag ctacttaatt tttaggagac agtaattcag ttgcagaagc     2400

tttcctctgc tattcccatt ctcttttaca aaactagttt tttttaaaaa atcaatgatc     2460

aattttatct tactacttta taacttttgc tgacttttat tctttgcatt gtatgtaatg     2520

tccatcagta taaattgaga ctgtgaattt ctaggaccca caaaagtggt attttttttt     2580

tgtacaagaa agtatagagg aagaggaagc tgggcattaa attacctcat ccagcagaaa     2640

ttcacggtag tatggtatat ttttattttt tatattttaa aatcaataat gtcaaatgtc     2700

attgtgtatg catgctttat aataaattta cacttgatca tttttctgga agcctatggg     2760

aactagtaca a                                                          2771


<210> 3981
<211> 1068
<212> DNA
<213> Homo sapiens

<400> 3981
atgaccggct ccgcggccga cactcaccgc tgcccccacc ccaaaggcgc caaaggcacc       60

cggtcccgga gcagccacgc gcggcccgtg agcctcgcca ccagcggggg ctcagaggag      120

gaggacaaag acggcggggt gctgttccac gtcaacaaga gcggcttccc catcgacagc      180

cacacctggg agcgcatgtg gatgcacgtg gccaaggtgc accctaaggg gggagaaatg      240

gtgggcgcca tcaggaacgc cgccttcttg gcaaagcctt caatacccca ggtcccaaac      300

tacaggctgt cgatgacgat cccagactgg ctccaggcga tccagaatta catgaagacc      360

ctacaatata atcacacagg gacccagttc tttgaaatta ggaaaatgag accgctgagt      420

gggttaatgg aaacagcaaa agaaatgacc cgagagtcct tgcctatcaa atgccttgaa      480

gctgtcatcc tgggcatcta cttaaccaat gggcagcctt ccattgagcg gttccccatc      540

agctttaaaa cctacttctc aggaaactac tttcaccacg ttgtgctggg gatttactgc      600

aatggccgct atggctcatt gggcatgagc cgcagggctg agctgatgga caagccattg      660

acttttcgga ctctgagtga cctcatcttt gactttgagg actcttacaa gaaatacctg      720

cacacagtca agaaggtcaa gattgggctg tacgtccccc atgagcctca tagcttccag      780

cccattgagt ggaagcagct ggtcctcaac gtctcaaaga tgctgagggc tgacataagg      840

aaggagctgg agaaatatgc cagggacatg agaatgaaga tcctgaaacc tgcaagtgcc      900

cactctccga cccaagtgag aagccgggga aaatccctgt cccccagaag gagacaggca      960

agccccccga ggaggctcgg ccggcgagag aagtcgcctg cactgcctga aaagaaggtg     1020

gctgatctga gcactctgaa tgaagtgggc tatcaaatcc gaatttag                  1068


<210> 3982
<211> 563
<212> DNA
<213> Homo sapiens

<400> 3982
gtcccaaccg ccgacgccga tgcggagctg agctggcttt cctccagggc tctggactcc       60

ctgctgagca agagagaaag aggcccgccc ttccaccagg acgcctgacc ctggggtcct      120

tcccaaaccc gggtctcttc cgactccggg cccaacagtt tgtgcgatta aagtgaagaa      180

acaatggcca gcaatcacaa atcttcagca gctcgccctg tttcaagagg tggagttggg      240

ttaacaggaa ggcctccttc tgggatacga cccctatcag gaaatattcg agtggcaact      300

gcaatgccac ctgggacagc aagaccaggt tctcgtggtt gtcccatagg gactggtgga      360

gttctgtctt ctcaaatcaa agttgcccat cgccctgtaa cacaacaagg tttgactgga      420

atgaaaactg ggacgaaagg tccccagagg caaattttag acaaatctta ctatcttggg      480

cttcttagaa gtaaaataag tgaacttaca actgaagtta ataaacttca gaagggaata      540

gaaatgtaca atcaagagaa ttc                                              563


<210> 3983
<211> 2287
<212> DNA
<213> Homo sapiens

<400> 3983
ctaagcctcg attgaaggag cacatccctt ccattgaagc tgcagaggag cagctgccac       60

cctgtgcacc cacacttgct taagggtcta gctggataac aaaaggaggc ccagaatcgg      120

tggagcttgg agatgagcga agcagtcctg caccaggttc tgaactaatt agctggtgga      180

ggggacaata cgagtttaaa cagcggctct gggtgcctaa gattctacat tttatacaga      240

catccttggt tccagagggg gctgagcagg ggggtccgag gtgagtctgt gagcatgtgc      300

aagtctgtac cagcttgtga aggacatgcc atgtcccctg agtactcata gaaagacacc      360

aacatgacaa aggtagtttg gctttatacc tagaaaaggc ccccaggtca caagcttctc      420

aggactttgt gggattttcc aggtgggccc tgaggggtgg cactaaagca gactcaagag      480

gagtctgggg tggaggtggg ttgcttggaa aagagggcgg aggaaaaagc taaatgcagt      540

cagccaggag gggctgccca ggacccaagt caaagagaag aatttgaaag ctttggaagc      600

aagtgctgtt gtgggggctg catagcccag ggctggctga agctgatcca ccacgctctg      660

ccactctggc tccacagagc acagagcttg tccctaaagc ttcctgtagc tgaccatgag      720

aaatggtcat gcagccacac acacttcccc agcccctctc tctgctctac cagcctgtca      780

cccacgtttg ggccacgaga agtcactgct ctgtaagtag ttgtgactgc agtgggtctt      840

tttggtcacc cctgtcctgg gcttacttca ggtggaagct tgaagctgga tggcagctga      900

gccagcagac cgattctgac acttacagat gaggaaacta aggcagagat ggtaggacct      960

gcccagtgtt acagctgagt aaagtggcag agctgggacc agaacccagg tttgctgact     1020

ccctgtctag cactccttcc ttcaggctat gtagtccctg agcagaatgt ggcatctcag     1080

gttgtgagaa atgatggagt tcaaatttat aacaaggaag gcttctaaag ggctaggaag     1140

gcttctaaag ggctggggct cacctgggac ctgtccagtc ttatttgagg agccacaccc     1200

ttagaggtca ttctggaaca gacctgggaa tccatggaat gtgctggaaa gagccctggg     1260

ctgggatctg gtccagttct ggtgctcaca tgctatgtgg tcttaagcaa gccccttccc     1320

ctctctggtg ctccaattac taaatgcaaa atgagggttt ggccccagtg cttttccagc     1380

tccgatgctc catggcccag ttctaacaga gagccctgat cttgaagtgg actcactccc     1440

ctgggctgga gcctggtaaa gataggaaaa gggtacacag tcccatcccg gtcactctgc     1500

cttcctgaag tgctctcctt gggtcctctg caggtgattt gtctacagca accaagagca     1560

aaacaagtga agacatcagc cagacctcca agtacagtcc catctactcg ccagacccct     1620

actatgcttc ggagtctgag tactggacct accatgggtc ccccaaagtg ccccgagcca     1680

gaaggttctc gtctggagga gaggaggatg attttgaccg cagcatgcac aagctccaaa     1740

gtggaattgg ccggctgatt ctgaaggaag aaatgaaggc ccggtcgagc tcctatgcag     1800

atccctggac ccctccccgg agctccacca gcagccggga agccctgcac acagctggct     1860

atgagatgtc cctcaatggc tcccctcggt cgcactacct ggctgacagt gatcctctca     1920

tctccaaatc tgcctccctg cctgcctacc gaagaaatgg gctgcacagg acacccagcg     1980

cagacctctt ccactacgac agcatgaacg cagtcaactg gggcatgcga gagtacaaga     2040

tctaccctta tgaactgctg ctggtgacta caagaggaag aaaccgactg cccaaggatg     2100

tagacaggac ccgtttagag cgccacctgt cccaggaaga gttctaccaa gtctttggca     2160

tgaccatctc tgagtttgac cggctggccc tctggaagag gaatgaactg aagaagcaag     2220

cccggctgtt ctaggcagag gctctataaa tatatatgca tttatataaa gatatatgta     2280

aaatctc                                                               2287


<210> 3984
<211> 224
<212> DNA
<213> Homo sapiens

<400> 3984
tcgggttctg tggacacagg caggaagctt aagaggctct gctgagcagg gacctgggga       60

agaggagagg agaggcagca gcatggcgag tgtcctgtcc cgacgccttg gaaagcggtc      120

cctcctggga gcccgggtgt tgggacccag tgcctcggag gggccctcgg ctgccccacc      180

ctcggagcca ctgctagaag gggccgctcc ccagcctttc acca                       224


<210> 3985
<211> 1094
<212> DNA
<213> Homo sapiens

<400> 3985
aagcaagcct cttataggca gcataagttg agtgttttta aaaatccatt taactacttt       60

gcctttttat tggagaactt aatccactta cgttcagggt tatcattcat aggctgctga      120

tactttggct gtgaggcaaa aaaggagaat ttatgatatc accaatgtct tagagggaat      180

tgacttgatt gaaaaaaagt caaaaaacag tatccagtgg aaaggtgtag gtgctggctg      240

taatactaaa gaagtcatag atagattaag atatcttaaa gctgaaattg aagatctaga      300

actgaaggaa agagaacttg atcagcagaa gttgtggcta cagcaaagca tcaaaaatgt      360

gatggacgat tccattaata atagattttc ctatgtaact catgaagaca tctgtaattg      420

ctttaatggt gatacacttt tggccattca ggcaccttct ggtacacaac tggaggtacc      480

cattccagaa atgggtcaga atggacaaaa gaaataccag atcaatctaa agagtcattc      540

aggacctatc catgtgctgc ttataaataa agagtcgagt tcatctaagc ccgtggtttt      600

tcctgttccc ccacctgatg acctcacaca gccttcctcc cagtccttga ctccagtgac      660

tccacagaaa tccagcatgg caactcaaaa tctgcctgag caacatgtct ctgaaagaag      720

ccaggctctg cagcagacat cagctacaga tatatcttca gcaggatcta ttagtggaga      780

tatcattgat gagttaatgt cttctgacgt gtttcctctc ttaaggcttt ctcctacccc      840

ggcagatgac tacaacttta atttagatga taacgaagga gtttgtgatc tgtttgatgt      900

ccagatacta aattattaga ttccatggaa acttgggact gttatctacc tctaactgtg      960

taacatttta gacttcttaa taacctaaat atttaaaata atgaatgtaa cacctttttt     1020

agttcactga ttctgaagtg ttcttcccta atactttctt tacttcacaa aacttcaacc     1080

ataaaaacaa aggg                                                       1094


<210> 3986
<211> 876
<212> DNA
<213> Homo sapiens

<400> 3986
gttgtcgacc ctgttcttcg ggagacccta ccaggttccg ttcacctgcc ccgcccccga       60

ctcagcgagg cctcctctgg ccgggcgtcc tcacggcgct ccataaacat aaatgagcat      120

attctgatgt actctttgga tctgaactca tcttcacaga tgccttcaat taagttgcag      180

agttctgatg gagagatatt tgaagttgat gtggaaattg ccaaacaatc tgtgactatt      240

aagaccatgt tggaagattt gggaatggat gatgaaggag atgatgaccc agttcctcta      300

ccaaatgtga atgcagcaat attaaaaaag gtcattcagt ggtgcaccca ccacaaggat      360

gaccctcctc ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt      420

tgggaccaag aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca      480

aactacttag acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc      540

aaggggaaaa ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa      600

gaggaggaag cccaggtacg caaagagaac cagtggtgtg aagagaagtg aaatgttgtg      660

cctgacactg taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa      720

ttgttaatat tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat      780

attgtcctca ttgcatgtgt agtttgagca cagatcccaa accttacggc caagtttctt      840

ctagtatgat ggaaagtttc ttttttcttt gctctg                                876


<210> 3987
<211> 1972
<212> DNA
<213> Homo sapiens

<400> 3987
ggcagagacc gcatattccg gaggggctgg ctccaggcca cgcgagccgg agctggagac       60

atttccagag ccttgaggat ggcaccggcc ctcgcacgct caactcctgc tcctcctctt      120

cgcaatgagt aaacgacgca gattaaagca aggagagcca atcatgactg gcaaaacaca      180

gaccagcaac gtcaccaata agaatgaccc caagtccatc aactcccgtg ttttcatcgg      240

caatctaaat acggcaattg tcaagaaagt tgacattgaa gccatttttt caaagtatgg      300

aaaaatagtt ggatgttccg ttcacaaagg ttatgcattt gtacagtaca tgagtgagcg      360

acatgcaaga gctgcagtgg ctggagaaaa tgccagagtc atcgccggcc aaccacttga      420

tatcaacatg gcaggagagc ccaaaccata cagaccaaaa cctggaaaca agaggcccct      480

ttctgcactt tacagacttg aatcaaagga acctttcctg tctgttggcg gttatgtctt      540

tgactatgat tactacagag atgatttcta caatcggtta tttgattacc acgggcgtgt      600

gcctccacct ccccgtgcag taattccgct gaagcgtccc agagtggcag tcacaacgac      660

tcgcaggggg aaaggagtct tttccatgaa aggtggatcg agatctactg ccagtgggtc      720

aacaggttct aaattgaaat cagatgagtt acagaccatc aagaaagaat taacccagat      780

caaaactaaa attgactcct tgctagggcg cctggagaag attgagaaac agcagaaggc      840

ggaggcagaa gctcagaaga agcaattgga agagagtcta gtgctgatcc aagaggaatg      900

tgtgtcagag attgcagatc actctacaga ggagcctgct gaaggagggc cagatgccga      960

tggagaagag atgacagatg ggatagagga ggacttcgat gaagatgggg gtcatgagct     1020

gtttctacag ataaagtgat ctgaaataac gcatgatgcc acaaagcaga aaagagaaac     1080

tgtgacaacc cccagaaatg tgaaaggagg tttcttactg gacagcagca tctttggttc     1140

aatttatata aaaacccaaa taaataaaat ggacagtatt gctcagtttt agaaattcca     1200

tttcttctat gttttaagct gtacaattgt caggttttta tggtttaaat tgtaaatgtg     1260

ttttcccctt tgctaattat gttttttttt tcagtcttaa aatgtgaaag gcatttatga     1320

atggtaaggg aaacactata tacaaatgta tatttgtaaa agctattttt atgattagca     1380

tgtttcactg ttgatcatat ataaagtcag gtgatattgc aattctgtat ttaaagctta     1440

tttccaacaa tgtcatgtaa gaaaagatgc atcttatgct agtttttata atttatttat     1500

aatttatagt ttaaagtact tcagatcata atgataaaat acttgaaaaa gttatatttc     1560

tgccctgtat aagcaccctt tttattaata aagaatgcag atatttcaga tgtgatataa     1620

tagttaaaga actgttggtt tgatctgtga ttaagttgag catgctccgc tctactgaac     1680

taaatgatcc aattattact tcagtctggg tatgagattc catggacaag taaggactag     1740

attgccaagg aaaagactgt cttgcccttg gatccaaaag tttaaattag tgcatacatc     1800

atgtcatttc acctcctgtt cctaggaact ctccattccc aagcattgcc agtgttttcc     1860

agataatctt agctgttgtc ttgtgctgtg gaaatggaag aaaccatctt cacagaccgt     1920

aggagaattc aacatataat ttcttaataa atactgtttc ttttaaaaca aa             1972


<210> 3988
<211> 579
<212> DNA
<213> Homo sapiens

<400> 3988
acttggaaag gaggagcagc ctcgggtggg actgagcgga tcttctggtt ctagagcggc       60

ctctgattgg acaaacttga cttagggacc gtgtctgtct gcgatggggc ttggtaaaga      120

aacagataca gagtgttcgc tgtggactcc cattattgtc ccagttgttt agaaaatatg      180

ccatcggctg aagccaaact aaaaaagaat agatgtgcca attgttttga ctgtcctggc      240

tgcatgcaca ccctctctac tcgggccacg agcatctcca cacagcttcc agatgaccca      300

gccaagacca ccatgaagaa agcctattac ctggcatgtg gattttgtcg ctggacgtct      360

agagatgtgg gcatggcaga caaatctgta gctagtggcg gttggcagga acctgaaaat      420

cctcacacac aacggatgaa caaattgatt gaatattacc agcagcttgc tcagaaagag      480

aaggttgagc gagatcgcaa gaaactggca cgacgtagaa actatatgcc tctggctttt      540

tcggacaaat atggtcttgg aaccaggctt cagcgacca                             579


<210> 3989
<211> 1697
<212> DNA
<213> Homo sapiens

<400> 3989
tttgctcagc ccgcctgcgc cgcttgggac gcctctgcct ttccctccct cccttccccg       60

acggcttctg gcggccaagt ggatgtggcg ggtgatcgag ccaccctgcc caggggcgcc      120

cagcactgag aatggcaaat cggttcattg gaaacttgga gctgataagg aagtctgggt      180

atgggtgatg ggcgaacacc atctagataa accctatgat gtgctctgta atgaaattat      240

tgctgagagg gcccggctga aagcagaaca ggaggcagaa gagcccagaa aaactcactc      300

tgaagaattc accaatagct tgaaaacaaa atcacagtac catgatctgc aggctccgga      360

taaccagcag actaaagaca tctggaagaa agtggcagaa aaggaggaac tggagcaagg      420

atcgaggcca gcaccaaccc tggaagaaga gaaaatccga tcactctcca gttcttcaag      480

aaatattcaa caaatgttgg cagattcaat caatcgtatg aaggcatatg catttcacca      540

gaagaaagaa tctatgaaga aaaaacaaga tgaagaaata aatcaaatag aagaagagag      600

aacgaagcag atttgtaaga gctggaaaga agactcggaa tggcaggcat ctctgcgaaa      660

atccaaagca gctgatgaga agagacgctc cttggctaaa caagcacgag aagactacaa      720

gaggttatcc ctcggggccc agaaaggaag aggcggtgag aggctgcaaa gccccttgcg      780

tgttccgcag aaaccagaaa gacctcccct tccacccaag cctcagttcc taaactcagg      840

ggcatatcct caaaaacctc ttagaaatca gggagtggtg aggacactgt ccagctctgc      900

ccaagaggac atcatccggt ggtttaaaga ggagcagcta ccacttcgag cgggctacca      960

gaaaacctca gacaccatag ccccctggtt ccatggaatt ctcacactca agaaagcaaa     1020

tgaacttctt ctgagcacag gcatgcccgg cagttttctc atccgagtca gtgaaaggat     1080

caaaggctat gccctgtcct atctgtcgga ggacggctgt aaacatttcc tcatcgatgc     1140

ctctgcagac gcctacagct tcctgggcgt ggaccagcta cagcatgcca ccttggcgga     1200

tttggtggaa tatcacaagg aggaacccat cacttccctg gggaaggagc tccttctcta     1260

tccctgtggt cagcaggacc agctgcctga ctacctggag ctgtttgagt gacagcctcc     1320

atcagggtca tcctacagcc tccaagcggg ctttcccctg gacaaatgcc actgcaacat     1380

ttatgtgtga agccaaaatc accctgcagc agagccaata ctgatcaact gaaagtaaag     1440

tatccatgga gtcctcattg acacctcttt tctgcacaaa tactggaatt caatgtcaag     1500

agaaaatgac ctctgctcaa aagggagaag agtctcaatt tcagcaagta cctgtcatga     1560

agggtatgac cttaatgatg tacataaaat aaaacaaatg aagaaatgga aaacttttag     1620

aaattaaggt gtacttgaaa acgaatatct atcatatgac ccctgcactc cctctgtatc     1680

atctcaggag gtttcag                                                    1697


<210> 3990
<211> 540
<212> DNA
<213> Homo sapiens

<400> 3990
gaaatctcca tgcatccgag ctcagtggag gaatgtttat tgagtccata gaaatttgag       60

cagggcatat ctctaggggt ttatgacagg ctgttttctt ttctcagtgt ggggatgaat      120

tgctccatta tcatctaaat tggaagaaac caacatgtct gacaaaagtg acttaaaagc      180

tgagctagag cgcaaaaagc agcgcttagc acagataaga gaagagaaga aacggaagga      240

agaggagagg aaaaagaaag aggctgatat gcagcagaag aaagaacccg ttcaggacga      300

ctctgatctg gatcgcaaac gacgagagac agaggctttg ctgcaaagca ttggtatctc      360

accggagccg cctctagtcc caacccctat gtctccctcc tcgaaatcag tgagcactcc      420

cagtgaagct ggaagccaag actcaggcga tctggggcca ttaacaagga ccctgcagtg      480

ggacacagac ccctcagtgc tccagctgca gtcagactca gaacttgggt atatgtctgc      540


<210> 3991
<211> 3409
<212> DNA
<213> Homo sapiens

<400> 3991
gagctgaggc ccgcgtcgat cctgggttgg aggaggtggc ggccgctgag gctgcggcgt       60

gaagacggcg ggcatggtgg ggcgggagaa agagctctct atacactttg ttcccgggag      120

ctgtcggctg gtggaggagg aagttaacat ccctaatagg agggttctgg ttactggtgc      180

cactgggctt cttggcagag ctgtacacaa agaatttcag cagaataatt ggcatgcagt      240

tggctgtggt ttcagaagag caagaccaaa atttgaacag gttaatctgt tggattctaa      300

tgcagttcat cacatcattc atgattttca gccccatgtt atagtacatt gtgcagcaga      360

gagaagacca gatgttgtag aaaatcagcc agatgctgcc tctcaactta atgtggatgc      420

ttctgggaat ttagcaaagg aagcagctgc tgttggagca tttctcatct acattagctc      480

agattatgta tttgatggaa caaatccacc ttacagagag gaagacatac cagctcccct      540

aaatttgtat ggcaaaacaa aattagatgg agaaaaggct gtcctggaga acaatctagg      600

agctgctgtt ttgaggattc ctattctgta tggggaagtt gaaaagctcg aagaaagtgc      660

tgtgactgtt atgtttgata aagtgcagtt cagcaacaag tcagcaaaca tggatcactg      720

gcagcagagg ttccccacac atgtcaaaga tgtggccact gtgtgccggc agctagcaga      780

gaagagaatg ctggtaagaa ggattcctga gtcctgtctt agcgaaggtc cgctttgtct      840

tttccatgct tgaactttca cagctgtact tggagtgtta ctgagtgaaa gccaaaagtg      900

cttttttaaa actaggagac caaacaaaag tagtttacat atacactgta ttcatgaaga      960

ataaaaatat tatgctcttc tgtttgaatt tatttcttat gtactataga tcccatcatt     1020

tcttttattg caaagtgtta ggaaacttca aaataatcat ctaaggtctt ttaagaagat     1080

actctttggg ggctgggcgt gatggctcac acctgtaatc ccagcacatt tgaaaaagtt     1140

ggtattaaat ataatatcca tacaaagaaa gatgagactg atttagttta gaatattaat     1200

aggatgacca cagtttttta atatatgaga attatatttt gtaatatata acatgacaat     1260

atttaagaaa gtttagctca acttgaaaaa tggttctatt aagtttttgt tgtagcttgg     1320

gataattaaa aatactcatt aaattgtact gttttcataa aaatttgtaa tgctttttta     1380

tattcccact aattaagtaa aattggagcc tttttttgat tttaaaaatt cttaaggttt     1440

aaattctaga aattgctctt ttaagtgttt tgctaagagt attagtagga atttgatttt     1500

agatatcttg tggagacctt tccagaaaaa gagggttgcc ttttagttcc tggaccttat     1560

tttaagtaag ctttttggtc aaacctattc tactcagctc aaaaagttga aactattgaa     1620

tttattgtgt catcgttctt aggatccatc aattaaggga acctttcact ggtctggcaa     1680

tgaacagatg actaagtatg aaatggcatg tgcaattgca gatgccttca acctccccag     1740

cagtcactta agacctgtaa gtacatggct gtaaaaacct ttagatccat tgctatggta     1800

tatattattg ctgtgttggg taacttcatt tctcagtact aatcaaagtg aactttgctt     1860

gtatgctggc tgttcatagt gctacttttc tctaaattat catctgtaga gaagatcatg     1920

agtattgaag tttgtagaaa atgtattatt gtcttgatca tgacaggcat ttggtttatt     1980

tttccaggga tgatcaaatc agatttctta cactaagagc aaaaataagt agcaaatata     2040

aaacctcaaa atggccaggc acaatggctc atgcctgtaa tcccaacact ttgggaggct     2100

gacgcaggag gatcccttga gcccaggaat ttgagactag cctgggcaat ggagggagat     2160

ctcatctctg tttaaaaata tatacatatt taaaaaaagg tcagggggaa caaagccctc     2220

aaaatatagc ctttcactta cttttgattt ttttgtgttt atctttcttt aaagattact     2280

gacagccctg tcctaggagc acaacgtccg agaaatgctc agcttgactg ctccaaattg     2340

gagaccttgg gcattggcca acgaacacca tttcgaattg gaatcaaaga atcactttgg     2400

cctttcctca ttgacaagag atggagacaa acggtctttc attagtttat ttgtgttggg     2460

ttcttttttt tttttaaatg aaaagtatag tatgtggcac tttttaaaga acaaaggaaa     2520

tagttttgta tgagtacttt aattgtgact cttaggatct ttcaggtaaa tgatgctctt     2580

gcactagtga aattgtctaa agaaactaaa gggcagtcat gccctgtttg cagtaatttt     2640

tctttttatc attttgtttg tcctggctaa acttggagtt tgagtatagt aaattatgat     2700

ccttaaatat ttgagagtca ggatgaagca gatctgctgt agacttttca gatgaaattg     2760

ttcattctcg taacctccat attttcagga tttttgaagc tgttgacctt ttcatgttga     2820

ttattttaaa ttgtgtgaaa tagtataaaa atcattggtg ttcattattt gctttgcctg     2880

agctcagatc aaaatgtttg aagaaaggaa ctttattttt gcaagttacg tacagttttt     2940

atgcttgaga tatttcaaca tgttatgtat attggaactt ctacagcttg atgcctcctg     3000

cttttatagc agtttatggg gagcacttga aagagcgtgt gtacatgtat tttttttcta     3060

ggcaaacatt gaatgcaaac gtgtattttt ttaatataaa tatataactg tccttttcat     3120

cccatgttgc cgctaagtga tatttcatat gtgtggttat actcataata atgggccttg     3180

taagtctttt caccattcat gaataataat aaatatgtac tgctggcatg taatgcttag     3240

ttttcttgta tttacttctt tttttaaatg taaggaccaa acttctaaac taattgttct     3300

tttgttgctt taatttttaa aaattacatt cttctgatgt aacatgtgat acatacaaaa     3360

gaatatagtt taatatgtat tgaaataaaa cacaataaaa ttaacactt                 3409


<210> 3992
<211> 674
<212> DNA
<213> Homo sapiens

<400> 3992
tcctatgaca gtacattttc ctatgtaact catgaagaca tctgtaattg ctttaatggt       60

gatacacttt tggccattca ggcaccttct ggtacacaac tggaggtacc cattccagaa      120

atgggtcaga atggacaaaa gaaataccag atcaatctaa agagtcattc aggacctatc      180

catgtgctgc ttataaataa agagtcgagt tcatctaagc ccgtggtttt tcctgttccc      240

ccacctgatg acctcacaca gccttcctcc cagtccttga ctccagtgac tccacagaaa      300

tccagcatgg caactcaaaa tctgcctgag caacatgtct ctgaaagaag ccaggctctg      360

cagcagacat cagctacaga tatatcttca gcaggatcta ttagtggaga tatcattgat      420

gagttaatgt cttctgacgt gtttcctctc ttaaggcttt ctcctacccc ggcagatgac      480

tacaacttta atttagatga taacgaagga gtttgtgatc tgtttgatgt ccagatacta      540

aattattaga ttccatggaa acttgggact gttatctacc tctaactgtt gaccaaaatc      600

tttctaggct acagtgctgt catcccgcat ctatacaaga aacctggatc aaatactttt      660

agtcccttct aaca                                                        674


<210> 3993
<211> 812
<212> DNA
<213> Homo sapiens

<400> 3993
aagcttgcgc cctgaggcgg tttccgttcc cggacgtttg gactctgtcc tggagaaggg       60

gaaggaaaaa gtaagacgta gaagtacact gagacttcgt cacacataaa acaagcacga      120

caaagaaaga gggcgcgaag ggactcctgg aagaaattga gtctacattt aagatcaccc      180

taaaagtagt gacggcctct tcattactcc aaaccccaga tttaagtcgg taggacgtct      240

tcgcgttgac ttgtggggaa tgtagtttcg atgctgccgg cgcgttttgt ttgcgacaga      300

aactacaacc cccaggggcc accgcgacgt tgcctgtggg tgcccgcgaa ccaacggtta      360

gcggtggcag gggctgactg agagcgtctg cttgacagag tctttctctg tcacccaggc      420

tggagtacag tggcacgatc tcggctccct gcaacgtccg cctcccgagt tcaagtgatt      480

ctcctgcctc agccacccga gtagctgggt ctacaggtgt gcgccaccat gcctggctaa      540

tttttgtatt tttaagagag acggggtttc accatgctgg ccaggctggt ctcgaactcc      600

tgacctcgtg atccgcctgc ctcagcccct caaagtgcta ggattagaga taatggattc      660

tgaattaatg catagtatag taggaagcta tcataaacct ccagaaagag tatttgttcc      720

ctcattcacc cagaatgaac catctcagaa ttgccatcct gcaaacttag aagttacctc      780

tcctaagata cttcatagcc caaatagcca ag                                    812


<210> 3994
<211> 3116
<212> DNA
<213> Homo sapiens

<400> 3994
atccccgtgg cgggggcgtg gccatggcgg gggcgctccg gcgggggcgg gccctgggct       60

cccgcccttc gggtcccaca gtttccagcc gccgctctcc tcagtgcccg gtggcccagg      120

agggcctggg agcccgaagc cgtccccgag tcgctcctag gtcactggcg cgatgcgggc      180

cgtcctctcg gctgatgggt tggaagccca gcgaggctag aggccagtcc caaagtttcc      240

aggcatcagg gctgcagccc aggagcctca aggcggcccg gcgggcgact ggacggccgg      300

acaggtcccg agcagcccgg cccaccatgg acccctctgc ccacaggtcc cgagcagccc      360

cgcccaacat ggacccagac ccccaggcgg gcgtgcaggt gggcatgcgg gtggtgcgcg      420

gcgtggactg gaagtggggc cagcaggacg gcggcgaggg cggcgtgggc acggtggtgg      480

agcttggccg ccacggcagc ccctcgacac ccgaccgcac agtggtcgtg cagtgggacc      540

agggcacgcg caccaactac cgcgccggct accagggcgc gcacgacctg ctgctgtacg      600

acaacgccca gatcggcgtc cggcacccca acatcatctg tgactgctgc aagaagcacg      660

ggctgcgggg gatgcgctgg aagtgccgtg tgtgcctgga ctacgacctc tgcacgcagt      720

gctacatgca caacaagcat gagctcgccc acgccttcga ccgctacgag accgctcact      780

cgcgccctgt cacactgagt ccccgccagg gcctcccgag gatcccacta aggggcatct      840

tccagggagc gaaggtggtg cgaggccccg actgggagtg gggctcacag gatggcaagc      900

cggcggagct gcagcgcagg gtgagtgctg acagccagcc cttccagcac ggggacaagg      960

tcaagtgtct gctggacact gatgtcctgc gggagatgca ggaaggccac ggcggctgga     1020

accccaggat ggcggagttt atcggacaga cgggcaccgt gcatcgtatc acggaccgcg     1080

gggacgtgcg cgtgcagttc aaccacgaga cgcgctggac cttccacccc ggggcgctca     1140

ccaagcacca ctccttctgg gtgggcgacg tggtccgggt catcggcgac cttgacacag     1200

tgaagcggct gcaggctggg catggcgagt ggacggacga catggcccct gccctgggcc     1260

gcgtcgggaa ggtggtgaaa gtgtttggag acgggaacct gcgtgtagca gtcgctggtc     1320

agcggtggac cttcagcccc tcctgcctgg tggcctaccg gcccgaggag gatgccaacc     1380

tggacgtggc cgagcgcgcc cgggagaaca aaagctcact gagcgtggcc ctggacaagc     1440

ttcgggccca gaagagtgac ccagagcacc cgggaaggct ggtggtggag gtggcgctgg     1500

gtaacgcagc ccgggctctg gacctgctgc ggaggcgccc agagcaggtg gacaccaaga     1560

accaaggcag gaccgctctg caagtggctg cctacctggg ccaggtggag ttgatacggc     1620

tgctgctaca agccagggcg ggcgtggacc tgccggacga cgagggcaac acggcactgc     1680

actacgcggc cctggggaac cagcccgagg ccaccagggt gctcctgagt gctgggtgcc     1740

gggcggacgc catcaacagc acccagagca cagcactgca cgtggccgtg cagaggggct     1800

tcctggaggt ggtgcgggcc ctgtgtgagc gcggctgtga cgtcaacctg cccgacgccc     1860

actcggacac gcccctgcac tccgccatct cggcgggcac tggagccagc ggcattgtcg     1920

aggtcctcac ggaggtgcca aacatcgatg ttaccgccac caacagccag ggtttcaccc     1980

tgctgcacca tgcctccctc aagggtcacg cgctagctgt gagaaagatt ctggctcggg     2040

cgcggcagct ggtggacgcc aagaaggagg acggcttcac ggcgctgcat ctggctgccc     2100

tcaacaacca ccgcgaggtg gcccagatcc tcatccggga gggccgctgt gacgtgaacg     2160

tgcgcaaccg gaagctgcag tccccgctgc atctcgccgt gcaacaggcc cacgtggggc     2220

tggtgccgct actggtggac gctgggtgca gtgtcaacgc cgaggacgag gagggggaca     2280

cagccctgca cgtggcgctg cagcgtcatc agctgctgcc cctggtggct gatggggccg     2340

ggggggaccc agggcccttg cagctgctgt ccaggctaca ggcctcgggc ctccccggca     2400

gcgcggagct gacggtgggc gcggcggtcg cctgcttcct ggcgctggag ggcgccgacg     2460

tgagctacac caaccaccgc ggtcggagcc cgctggacct ggccgccgag ggtcgcgtgc     2520

tcaaggccct tcagggctgc gcccagcgct tccgggagcg gcaggcgggc gggggcgcgg     2580

ccccgggccc caggcaaacg ctcgggaccc ccaacaccgt gacgaacctg cacgtgggcg     2640

ccgcgccggg gcccgaggcc gctgagtgcc tggtgtgctc cgagctggcg ctgctggtgc     2700

tgttctcgcc gtgccagcac cgcaccgtgt gtgaggagtg cgcgcgcagg atgaagaagt     2760

gcatcaggtg ccaggtggtc gtcagcaaga aactgcgccc agacggctct gaggtggcga     2820

gcgccgcccc cgcccccggc ccgccgcgcc agctggtgga ggagctgcag agccgctacc     2880

ggcagatgga ggaacgcatc acctgcccca tctgcatcga cagccacatc cgcctcgtgt     2940

tccagtgcgg ccacggcgca tgcgccccct gcggctccgc gctcagcgcc tgccccatct     3000

gccgccagcc catccgcgac cgcatccaga tcttcgtgtg agccgcgccg tccgccgcgc     3060

ccgagctgcc ttcgcgtgcc cccgccctgt gttttataaa aagaaagatt ctcgga         3116


<210> 3995
<211> 294
<212> DNA
<213> Homo sapiens

<400> 3995
atggcatctt ctgcagagct ggacttcaac ctgcaggctc ttctggagca gctcagccag       60

gatgagttga gcaagttcaa gtctctgatc agaacaatct ccctgggaaa ggagctacag      120

accgtccccc agacagaggt agacaaggct aatgggaagc aactggtaga aatcttcacc      180

agccactcct gcagctactg ggcagggatg gcagccatcc aggtctttga aaagatgaat      240

caaacgcatc tgtctgggag agctgatgaa cactgtgtga tgcccccacc ttaa            294


<210> 3996
<211> 813
<212> DNA
<213> Homo sapiens

<400> 3996
gcgccctgag gcggtttccg ttcccggacg tttggactct gtcctggaga aggggaagga       60

aaaaatggga ctgtctagtt gcaaaaacaa gctcagggat cccactgatt ctactttacg      120

ataatggatt ctgaattaat gcatagtata gtaggaagct atcataaacc tccagaaaga      180

gtatttgttc cctcattcac ccagaatgaa ccatctcaga attgccatcc tgcaaactta      240

gaagttacct ctcctaagat acttcatagc ccaaatagcc aagctcttat tttagcctta      300

aaaactcttc aggaaaaaat tcatcgttta gagctggaga gaacacaagc tgaagataac      360

ctgaacattc tttccagaga agcagcacag tataagaagg ccttagagaa tgaaacaaat      420

gagagaaatc tggcacacca ggagctgata aagcagaaaa aagatataag tatacagtta      480

agctcagccc agtctcgttg tactcttcta gagaagcaac tagaatatac aaagagaatg      540

gttctcaacg tagagcgaga aaagaacatg atcctagaac aacaggccca gcttcagagg      600

gaaaaagaac aagatcagat gaagctgtat gcaaaacttg aaaagcttga tgtcttagaa      660

aaagagtgtt tcagacttac aacaactcag aaaactgctg aggacaagat taaacattta      720

gaagaaaaac ttaaggaaga agaacatcag cgtaagctat ttcaagacaa agcttctgag      780

cttcaaactg gacttgaaat cagtaaaatt ata                                   813


<210> 3997
<211> 2856
<212> DNA
<213> Homo sapiens

<400> 3997
aggtcgaccg ggtcaggtgg ttgggtgacg ccccaggaaa gcgctccagg ccgagggcgg       60

gcggcgccgc cgcgcccgac gcctctgggg gtggggactt cgcgggagtc gccggcggag      120

gcgaggagga gctctgcgcg gcgcggcggg cgatccgagc cgggacgggc tgcaggcggg      180

ggtgctgcag aggacacgag gcggcgggct ggagacatgg accgcggcga gcaaggtctg      240

ctgagaacag acccagtccc tgaggaagga gaagatgttg ctgccacgat cagtgccaca      300

gagaccctct cggaagagga gcaggaagag ctaagaagag aacttgcaaa ggtagaagaa      360

gaaatccaga ctctgtctca agtgttagca gcaaaagaga agcatctagc agagatcaag      420

cggaaacttg gaatcaattc tctacaggaa ctaaaacaga acattgccaa agggtggcaa      480

gacgtgacag caacatctgc ttacaagaag acatctgaaa ccttatccca ggctggacag      540

aaggcctcag ctgctttttc gtctgttggc tcagtcatca ccaaaaagct ggaagatgta      600

aaattgcaag ccttttcaca ttcctttagt atacgttcca ttcagcattc aattagcatg      660

cctgctatga gaaactcccc aacttttaaa tcatttgaag aaaaggtcga aaacttaaag      720

tctaaagtag ggggaaccaa gcctgctggt ggtgattttg gagaagtctt gaattcggct      780

gcaaatgcta gtgccaccac cacggagcct cttccagaaa agacacagga gagcctgtga      840

gattcctacc tttgttctgc tacccactgc cagatgctgc aagcgaggtc caagcacatc      900

ttgtcaacat gcattgccat gaatttctac cagatgtgct tttatttagc tttacatatt      960

cctttgacca aatagtttgt gggttaaaca aaatgaaaat atcttcacct ctattcttgg     1020

gaaacaccct ttagtgtaca tttatgttcc tttatttagg aaacaccatt ataaaaacac     1080

ttatagtaaa tggggacatt cactataatg atctaagaag ctacagattg tcatagttgt     1140

tttcctgctt tacaaaattg ctccagatct ggaatgccag tttgaccttt gtcttctata     1200

atatttcctt tttttcccct ctttgaatct ctgtatattt gattcttaac taaaattgtt     1260

ctcttaaata ttctgaatcc tggtaattaa aagtttgggt gtattttctt tacctccaag     1320

gaaagaacta ctagctacaa aaaatatttt ggaataagca ttgttttggt ataaggtaca     1380

tattttggtt gaagacacca gactgaagta aacagctgtg catccaattt attatagttt     1440

tgtaagtaac aatatgtaat caaacttcta ggtgacttga gagtggaacc tcctatatca     1500

ttatttagca ccgtttgtga cagtaaccat ttcagtgtat tgtttattat accacttata     1560

tcaacttatt tttcaccagg ttaaaatttt aatttctaca aaataacatt ctgaatcaag     1620

cacactgtat gttcagtagg ttgaactatg aacactgtca tcaatgttca gttcaaaagc     1680

ctgaaagttt agatctagaa gctggtaaaa atgacaatat caatcacatt aggggaacca     1740

ttgttgtctt cacttaatcc atttagcact atttaaaata agcacaccaa gttatatgac     1800

taatataact tgaaaatttt ttatactgag gggttggtga taactcttga ggatgtaatg     1860

cattaataaa aatcaactca tcattttcta cttgttttca atgtgttgga aactgtaaaa     1920

tgatactgta gaacctgtct cctactttga aaactgaatg tcagggctga gtgaatcaaa     1980

gtgtctagac atatttgcat agaggccaag gtattctatt ctaataactg cttactcaac     2040

actaccacct tttccttata ctgtatatga ttatggccta caatgttgta tttgttattt     2100

attaaattgt gattgtttta ttattgttta tgccaaatgt taactgccaa gcttggagtg     2160

acctaaagca ttttttaaaa gcatggctag atttacttca gtataaatta tcttatgaaa     2220

accaaatttt aaaagccaca ggtgttgatt gttataaaat aacatgctgc cattcttgat     2280

tgctagagtt tttgttagta ctttggatgc aattaaaact atgtgctatc acatgtgaaa     2340

agcttaataa attccatcta tcagtagtat aggtctcaat atttattatg agaccagtgg     2400

tctggaaaca gcttgttgta ccgaatcaac tggagtctat gcttaaaaaa aaaaaatttt     2460

tttttaacca tccttaaatt attgcttaat ggtatcatat taacatattc taaataaggg     2520

ctttaaggca caggctgttg aagcattttc tcagaggagt ggatctgtag aagtctgtct     2580

ttctatagaa atattgtgct tactcaagtg ttaaattatt ttttctatga actagtctac     2640

ttcttaaaat tcaaacatat tcttttgatc acattgtttc ttgagcatcc tgccctgcta     2700

ctaacttttc aacaaggcaa aatggagtaa agtggcaatt tctttagatg agtgaaatac     2760

cctcaagtct cttttctgcc caaaaaggga aaagtgatag aaatgggggt ggcaagtggg     2820

gtgagtggat gaaggtgggt attgggggtg gctgtg                               2856


<210> 3998
<211> 493
<212> DNA
<213> Homo sapiens

<400> 3998
gtagagcctt tgttggggga tgaggagtgt cttgggtcga gaacaggccc ctgtaaccca       60

ctgagcgccc cttcattccg tctctctccg ccctttgtag agggtcacca tgaagttcaa      120

tcccttcgtt acctcggacc gcagtaaaaa ccgcaaacgt cacttcaatg ccccctcaca      180

cgtgcgcagg aagatcatgt catccccgct ctccaaggag ctgcggcaga agtacaatgt      240

ccgctccatg cccatccgca aggacgacga ggtccaggta gttcgaggac actacaaagg      300

tcagcaaatt ggcaaggtag tccaggtgta cagaaagaaa tatgtcatct acatcgagcg      360

ggtgcagcgt gagaaggcca acggcacaac tgtccacgtg ggcattcacc caagcaaggt      420

ggttatcacc aggctaaaac tggacaagga tcggaaaaaa attcttgaac gcaaagccaa      480

gtctcgacaa gtt                                                         493


<210> 3999
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 3999
gggctcacaa aacagctact tgatgacacc attggaattc accccacatg tggggaggtg       60

ttcacgactt tggaaatcac aaagtcgtca ggactagaca tcactcagaa aggctgctga      120

ggctaggcct gctgctgttt agttctcctt gtcatattct catttctctc aaagataaga      180

atgctctcgg ataaaatgag cctgtgctca tgacagctgc tctgttactc agggaccagt      240

gcagggctgt cttacgacac ttagatgaga aagtagacaa ggaaagagga cagcagtggg      300

catctgcctt gtggtcttgc tgacagcgag aagcagtggg actgcttcct tgacgcctta      360

gcttggagcc ccgttatgag gtcctctcag attgcagcgg gatgtttcat gaaagcctag      420

acccggaaga ataggaggat aggagactgc agcagctgac ctctggaagc cagagctgga      480

tgagggacct gagcgagagg agacttgggc agccggagct gaaagctgag cagcagatgc      540

cactggagcc tgtgagggca cgattgagtg tggggctggc ttgctgctgc tcccacacca      600

ctgcagaggc gtcctctctg gaacatggag acaaggtttt tggacagggg tttcccagtc      660

ccctggaaga gattaagaga ctactgaaga tctccagggc actgcaagcc agatctgtac      720

cctccaccca ggagaaggca aaatgtcttt ctggagagcc tgggcagcca gaggggaaag      780

gtcaagaaac ctatcctggc cctgggaaag tggagggtaa ggcagagcca gccatgagaa      840

aggatgatgt ttgcccaggc atgaaatgta tcagcggatg atctctcaca tggaagaagc      900

caaagcagct acacccaatg gcttagcaat aagaaacacc aaaccagaca aacaccactg      960

ctgctgggaa agggacctgg cagaaggaaa aggctgttca gagagcagag gtatttcgtg     1020

tgagcctttt agggcttctt gtctctttag accacatgca catattactt gtataaaata     1080

atgcaccaga tacaaacaat gaaatacaag tgctgagttc gatagactca taca           1134


<210> 4000
<211> 1984
<212> DNA
<213> Homo sapiens

<400> 4000
cggcgcccgg ggcgggctca ggtgcggggt tgggcggcga gagcggccgc ggcgggtgtc       60

cggtgtccgg tgtccggtgt ccggtgtctg gagccgctgg ctaggttcag tgaacagcat      120

tttggacagg acatttggtg ccaggtctga gtagccagtt tgctgaatta ttgtcccagt      180

cagccaggat tgtgagctgt ttgggaagtt tcgtggaaac gcccaagtgc cagcacaggt      240

ggagggacac ctggaggcca gtttcaggaa cttttgccac aagtataaaa gacttcagaa      300

gtgcaaagat gctgaaacag atactgtcgg agatgtacat agatcctgat ctactggcag      360

agctcagcga agaacagaaa cagatcctgt tcttcaagat gagagaggaa cagatccgac      420

gatggaaaga aagagaagca gctatggaaa gaaaggagtc cctgccagtg aaacccagac      480

caaagaaaga gaatggcaaa tcggttcatt ggaaacttgg agctgataag gaagtctggg      540

tatgggtgat gggcgaacac catctagata aaccctatga tgtgctctgt aatgaaatta      600

ttgctgagag ggcccggctg aaagcagaac aggaggcaga agagcccaga aaaactcact      660

ctgaagaatt caccaatagc ttgaaaacaa aatcacagta ccatgatctg caggctccgg      720

ataaccagca gactaaagac atctggaaga aagtggcaga aaaggaggaa ctggagcaag      780

gatcgaggcc agcaccaacc ctggaagaag agaaaatccg atcactctcc agttcttcaa      840

gaaatattca acaaatgttg gcagattcaa tcaatcgtat gaaggcatat gcatttcacc      900

agaagaaaga atctatgaag aaaaaacaag atgaagaaat aaatcaaata gaagaagaga      960

gaacgaagca gatttgtaag agctggaaag aagactcgga atggcaggca tctctgcgaa     1020

aatccaaagc agctgatgag aagagacgct ccttggctaa acaagcacga gaagactaca     1080

agaggttatc cctcggggcc cagaaaggaa gaggcggtga gaggctgcaa agccccttgc     1140

gtgttccgca gaaaccagaa agacctcccc ttccacccaa gcctcagttc ctaaactcag     1200

gggcatatcc tcaaaaacct cttagaaatc agggagtggt gaggacactg tccagctctg     1260

cccaagagga catcatccgg tggtttaaag aggagcagct accacttcga gcgggctacc     1320

agaaaacctc agacaccata gccccctggt tccatggaat tctcacactc aagaaagcaa     1380

atgaacttct tctgagcaca ggcatgcccg gcagttttct catccgagtc agtgaaagga     1440

tcaaaggcta tgccctgtcc tatctgtcgg aggacggctg taaacatttc ctcatcgatg     1500

cctctgcaga cgcctacagc ttcctgggcg tggaccagct acagcatgcc accttggcgg     1560

atttggtgga atatcacaag gaggaaccca tcacttccct ggggaaggag ctccttctct     1620

atccctgtgg tcagcaggac cagctgcctg actacctgga gctgtttgag tgacagcctc     1680

catcagggtc atcctacagc ctccaagcgg gctttcccct ggacaaatgc cactgcaaca     1740

tttatgtgtg aagccaaaat caccctgcag cagagccaat actgatcaac tgaaagtaaa     1800

gtatccatgg agtcctcatt gacacctctt ttctgcacaa atactggaat tcaatgtcaa     1860

gagaaaatga cctctgctca aaagggagaa gagtctcaat ttcagcaagt acctgtcatg     1920

aagggtatga ccttaatgat gtacataaaa taaaacaaat gaagaaatgg aaaactttta     1980

gaaa                                                                  1984


<210> 4001
<211> 679
<212> DNA
<213> Homo sapiens

<400> 4001
agtagccggg tgagtggagg ctggagtttt ctcggacagt gaactctacc gccccagggt       60

caccatgaag ttcaatccct tcgttacctc ggaccgcagt aaaaaccgca aacgtcactt      120

caatgccccc tcacacgtgc gcaggaagat catgtcatcc ccgctctcca aggagctgcg      180

gcagaagtac aatgtccgct ccatgcccat ccgcaaggac gacgaggtcc aggtagttcg      240

aggacactac aaaggtcagc aaattggcaa ggtagtccag gtgtacagaa agaaatatgt      300

catctacatc gagcgggtgc agcgtgagaa ggccaacggc acaactgtcc acgtgggcat      360

tcacccaagc aaggtggtta tcaccaggct aaaactggac aaggatcgga aaaaaattct      420

tgaacgcaaa gccaagtctc gacaagttgg aaaagagaaa ggcaaatata aagaagaact      480

tattgagaaa atgcaggaat aaatagaacc tgttgtgcaa ccacggttta accggagatt      540

ttgaggctag ggtgtgtttc tttcgaactt ttcggaatgt ctggaacatt tcatttcctg      600

ttttgttacc tgtgcctctg taaatctact tttgcaattt taagtaataa ttttatgaat      660

aaaaatggga aatgcttcc                                                   679


<210> 4002
<211> 965
<212> DNA
<213> Homo sapiens

<400> 4002
aagcgccccc ggaggcgcta agcttgcgcc ctgaggcggt ttccgttccc ggacgtttgg       60

actctgtcct ggagaagggg aaggaaaaaa cagagtcttt ctctgtcacc caggctggag      120

tacagtggca cgatctcggc tccctgcaac gtccgcctcc cgagttcaag tgattctcct      180

gcctcagcca cccgagtagc tgggtctaca ggtgtgcgcc accatgcctg gctaattttt      240

gtatttttaa gagagacggg gtttcaccat gctggccagg ctggtctcga actcctgacc      300

tcgtgatccg cctgcctcag cccctcaaag tgctaggatt agagataatg gattctgaat      360

taatgcatag tatagtagga agctatcata aacctccaga aagagtattt gttccctcat      420

tcacccagaa tgaaccatct cagaattgcc atcctgcaaa cttagaagtt acctctccta      480

agatacttca tagcccaaat agccaagctc ttattttagc cttaaaaact cttcaggaaa      540

aaattcatcg tttagagctg gagagaacac aagctgaaga taacctgaac attctttcca      600

gagaagcagc acagtataag aaggccttag agaatgaaac aaatgagaga aatctggcac      660

accaggagct gataaagcag aaaaaagata taagtataca gttaagctca gcccagtctc      720

gttgtactct tctagagaag caactagaat atacaaagag aatggttctc aacgtagagc      780

gagaaaagaa catgatccta gaacaacagg cccagcttca gagggaaaaa gaacaagatc      840

agatgaagct gtatgcaaaa cttgaaaagc ttgatgtctt agaaaaagag tgtttcagac      900

ttacaacaac tcagaaaact gctgaggaca agattaaaca tttagaagaa aaacttaagg      960

aagaa                                                                  965


<210> 4003
<211> 2107
<212> DNA
<213> Homo sapiens

<400> 4003
cgctggcgtt ccgcgcacgc cggctcactg cgcctgcccg gcgtgtggac gccacacgct       60

cccggaagtg ggaggtggcc gctggagttt gtgtggccgc cgccgcggga acgcgagccc      120

ggtaattttt caacggagaa aggcgaggct ttcgggctct gcagagtgag agttagcaag      180

tgtccggctc cagcaactct cctctggcgt gacagccggc atggaggatc cacagagtaa      240

agagcctgcc ggcgaggccg tggctctcgc gctgctggag tcgccgcggc cggagggcgg      300

ggaggagccg ccgcgtccca gtcccgagga aactcaacag tgtaaatttg atggccagga      360

gacaaaagga tccaagttca ttacctccag tgcgagtgac ttcagtgacc cggtttacaa      420

agagattgcc attacgaatg gctgtattaa tagaatgagt aaggaagaac tcagagctaa      480

gctttcagaa ttcaagcttg aaactagagg agtaaaggat gttctaaaga agagactgaa      540

aaactattat aagaagcaga agctgatgct gaaagagagc aattttgctg acagttatta      600

tgactacatt tgtattattg actttgaagc cacttgtgaa gaaggaaacc cacctgagtt      660

tgtacatgaa ataattgaat ttccggttgt tttactgaat acgcatactt tagaaataga      720

agacacgttt cagcagtatg taagaccaga gattaacaca cagctgtctg atttctgcat      780

cagtctaact ggaattactc aggatcaggt agacagagct gataccttcc ctcaggtact      840

aaaaaaagta attgactgga tgaaattgaa ggaattagga acaaagtata aatactcact      900

tttaacagat ggttcttggg atatgagtaa gttcttgaac attcagtgtc aactcagcag      960

gctcaaatac cctccttttg cgaaaaagtg gatcaatatt cggaagtcat atggaaattt     1020

ttacaaggtt cctagaagcc aaaccaaact gacaataatg cttgaaaaat taggaatgga     1080

ttatgatggg cggcctcact gtggtcttga tgactctaag aatatcgccc gaatagcagt     1140

tcgaatgctt caggatgggt gtgaactccg aatcaacgag aaaatgcatg caggacagct     1200

aatgagtgtg tcctcttcct taccaataga gggcactcca ccaccacaaa tgccacattt     1260

tagaaagtaa caacagtttt gtgtgtggat cattccaatt gaagttgcta tgaagaggga     1320

gaagtttctg cctggattga aacaaaaaaa cacaggcgtc acaagcatgt tacctattaa     1380

gagagagagg gtatctctga agactaatta aaatggtaat ttttaaaaag atgtgaccag     1440

ttgactttta gtatatcatc ccaagtatta tccccaaaat gataatgcaa aacagaataa     1500

tttggagacc aggagaaaaa ctggtatgat tactggggag gggaagaagc acaggtggtc     1560

aagataataa tgcatgtttg gcctcagctg tagttgccaa agaaactacc tgcctcacag     1620

atgagcacgc acgggtgcat tgtcaaagtc tgagaaggat gtattgtact ttgaaggaag     1680

actttccatt tctaagctac catggagaag tatatgctcc tcgagaccag agactgtgac     1740

ttctgcatct ttgattccag cgacatatga taaaatgttt tgcacatagt tgaatccagc     1800

gttgatacat gaaggacagc attacatctt ttttctatta tacttagaaa tttcctcttt     1860

gttctgcacc accaacctgt atatcaagcc tccttgcccc acaaagcttc caaagcccgt     1920

aaatttgtta atctagagca ggggtcagca aactaccacc catgggccaa atctggctgc     1980

tgcctatttt tgtatggcct acaaactatg gtttttatat tcccttttgt taatggctca     2040

aaataatatt ttgtataata cgaaaattac gaaattttag tttctctaaa taaagttttg     2100

gaaagaa                                                               2107


<210> 4004
<211> 692
<212> DNA
<213> Homo sapiens

<400> 4004
gctgtagtgg cttcgtcttc ggtttttctc ttccttcgct aacgcctccc ggctctcgtc       60

agcctcccgc cggccgtctc cttaacaccg aacaccgtga gtagccgccc actgaactgg      120

aaagggtcgt ggctaccgga ttgcgtgccg gctggcctca ccgctgcggt ttgggcctgc      180

ccgcggcggg cggtgactgg gcctggcctt ctttcgggcc cggtggatcg cgttgtcgac      240

cctgttcttc gggagaccct accagatgcc ttcaattaag ttgcagagtt ctgatggaga      300

gatatttgaa gttgatgtgg aaattgccaa acaatctgtg actattaaga ccatgttgga      360

agatttggga atggatgatg aaggagatga tgacccagtt cctctaccaa atgtgaatgc      420

agcaatatta aaaaaggtca ttcagtggtg cacccaccac aaggatgacc ctcctcctcc      480

tgaagatgat gagaacaaag aaaagcgaac agatgatatc cctgtttggg accaagaatt      540

cctgaaagtt gaccaaggaa cactttttga actcattctg gctgcaaact acttagacat      600

caaaggtttg cttgatgtta catgcaagac tgttgccaat atgatcaagg ggaaaactcc      660

tgaggagatt cgcaagacct tcaatatcaa aa                                    692


<210> 4005
<211> 577
<212> DNA
<213> Homo sapiens

<400> 4005
attacgagat tggcttggat tctgtcggat ggacttgggg ctagctgcgg cggggctgga       60

tggtgctgta ttgaattttt ggacggtact gcattggagg attttaagct tgggcagtag      120

gacattgtat taatctgttt tcacattgcc aatgaagaca tagcccagac ctgccaattt      180

actaaagaaa ggaggccaga taaccatgtc agccacagtt gtagatgcag ttaatgctgc      240

acccctatcg gggtccaaag aaatgagttt ggaagaacca aagaagatga ccagagagga      300

ctggagaaag aagaaggagc tagaagaaca gcgaaaattg ggcaatgctc ctgcagaagt      360

tgatgaagaa ggaaaagaca tcaaccccca tattcctcag tatatttctt cagtgccatg      420

gtatattgat ccttcaaaaa gacctacttt aaaacaccag agaccacaac cagaaaaaca      480

aaagcagttc agctcatctg gagaatggta caagaggggt gtaaaagaga attccataat      540

tactaagtac cgcaaaggag catgtgaaaa ttgtggg                               577


<210> 4006
<211> 1144
<212> DNA
<213> Homo sapiens

<400> 4006
ggaggggaga cgcgaaactt tccgggcgct tcctcccgcg gtcccggagc cgtcgcagcg       60

ccgggaggtg tcgtcgtcgc gggcggtggc ggccgacgcc atgttggggt ctgtgagaaa      120

cggggcgctc ccggccgctc ccctcgcgcc ggggccggcc cgcgggccag ttgccgccgc      180

cgtcccgcca gcccgggagc gagccgcgcc cgcccgtagg acgccgccgc cgccgcgggg      240

ggacgggggc cgccgggcta ttagtgaaag atggtggatc gcttggcaaa cagtgaagca      300

aatactagac gtataagtat agtggaaaac tgttttggag cagctggtca acctttaact      360

atacctggac gagttcttat tggagaagga gtattgacta agttgtgcag gaaaaagccc      420

aaagcaaggc agtttttctt gtttaatgat attcttgtat atggcaatat tgtcatccag      480

aagaaaaaat ataacaaaca acatattatt cccctggaaa atgtcactat tgattccatc      540

aaagatgagg gagacttaag gaatggatgg ctaatcaaga caccaactaa atcttttgca      600

gtttatgctg ccactgctac ggagaaatca gaatggatga atcatataaa taaatgtgtt      660

actgatttac tctccaaaag tgggaagaca cccagtaatg aacatgctgc tgtctgggtt      720

cctgactctg aggcaactgt atgtatgcgt tgtcagaaag caaaattcac acctgttaat      780

cgtcgccacc attgccgcaa atgtggtttt gttgtctgtg ggccctgctc tgaaaagaga      840

tttcttcttc ccagccagtc ctctaagcct gtgcggattt gtgacttctg ctatgacctg      900

ctttctgctg gggacatggc cacatgccag cctgctagat cagactctta cagccagtca      960

ttgaagtctc ctttaaatga tatgtctgat gatgatgacg atgatgatag cagtgactaa     1020

ggacacattt gggagtattt aatcaggtgt ggctatctga gaaatcaact ttgggggaaa     1080

tgtaagattc tgagctctct ctctgttttg ttctagccat gaatttgcct gagaaacttg     1140

taac                                                                  1144


<210> 4007
<211> 233
<212> DNA
<213> Homo sapiens

<400> 4007
accctgccct atgtgtcgcg ggaacacatg tcaccccaca gctctctttg agtgacctcc       60

cgaccaccca ttcctgccta accctagcat tccttcctca gcctcaagag ggtcaccatg      120

aagttcaatc ccttcgttac ctcggaccgc agtaaaaacc gcaaacgtca cttcaatgcc      180

ccctcacacg tgcgcaggaa gatcatgtca tccccgctct ccaaggagct gcg             233


<210> 4008
<211> 1734
<212> DNA
<213> Homo sapiens

<400> 4008
aattccgacg gggacgcgct gaggagcagg ggtgaagggt gaaaagcgtc attcgaggtc       60

cgggtccggc ttgcggggtc agcgaactgg agaggcgcca tgggctggat cacagaagat      120

cttattagac ggaatgctga acacaacgac tgtgtcattt tttccctgga ggaactctcg      180

ttgcatcagc aagaaataga aagactagaa cacattgata aatggtgccg ggatttaaaa      240

attctctatc ttcaaaataa tcttattggg aaaattgaaa atgttagcaa actcaagaaa      300

cttgaatatt tgaatttagc tttaaacaac attgaaaaaa tagaaaactt ggaaggatgt      360

gaagagctgg caaaacttga cctgactgtg aatttcattg gagagctgag cagcattaaa      420

aacttgcagc acaatatcca tctgaaggag ctctttctca tggggaaccc atgtgcttcc      480

tttgaccact atagggagtt cgtggtagca actcttccac aattaaagtg gttggatggt      540

aaagaaatag agccttcaga aaggattaag gcattgcagg actattcagt aattgaacca      600

caaatcagag agcaggaaaa agatcactgt cttaaacgag ccaaactcaa ggaagaggct      660

cagaggaaac accaagaaga ggataaaaat gaagacaaga gaagtaacgc aggctttgat      720

ggacgttggt acacagacat caatgctact ctttcctctt tagagagcaa agaccaccta      780

caggcaccag acacagagga acacaacaca aagaaattag acaacagtga agatgacttg      840

gaattctgga ataagccctg tttgtttact cctgaatcaa gattggaaac tcttagacac      900

atggaaaaac aacggaagaa acaggaaaaa ttaagtgaaa aaaagaagaa agtgaaacca      960

cccaggactt tgatcactga agatgggaaa gccctaaatg tgaatgagcc caaaattgac     1020

ttctctttga aagataacga aaagcagatc atcctggacc ttgctgtcta taggtatatg     1080

gatacctctt taatcgatgt tgatgtgcaa ccaacttacg tgcgagtaat gatcaaagga     1140

aagccatttc agcttgtcct tcctgcagaa gtgaaacccg atagtagttc tgctaaaaga     1200

tctcagacaa cgggtcattt ggtcatctgc atgcccaagg taggagaagt aatcacaggt     1260

ggtcagcgag cattcaaatc tatgaaaact acctcggaca ggagcagaga acaaacaaat     1320

acaagaagca agcacatgga gaaactagaa gtagacccta gcaagcactc attccctgat     1380

gtgactaaca tagttcaaga gaaaaaacac acacccagaa gacgacctga acccaaaatt     1440

ataccaagtg aggaagaccc aacctttgaa gacaaccctg aagtgcctcc gctgatttga     1500

aacatctggc tgcgttgcca ttggctgaga cccaccaggt ccagttttgg ttggtgtaga     1560

gaccatatgc atattattcc tgggataaac acagagttat ttgtcaatat cgctgctcca     1620

gtgttttaac tcttactttg catagtaata tccttaagat agcttaaaat taaaatgtat     1680

gtcttaaatg ctataactca tcatttacct ataataaagg gttggtattg aaaa           1734


<210> 4009
<211> 652
<212> DNA
<213> Homo sapiens

<400> 4009
tcgtcatggc cagtgtctgt ctggcgcccg gtgcccaggc actgtgcgag accagtccgc       60

aggggcgact cggagagcgc cgggccgcgg cgggagaaga gcctgcagcg attaaagtga      120

agaaacaatg gccagcaatc acaaatcttc agcagctcgc cctgtttcaa gaggtggagt      180

tgggttaaca ggaaggcctc cttctgggat acgaccccta tcaggaaata ttcgagtggc      240

aactgcaatg ccacctggga cagcaagacc aggttctcgt ggttgtccca tagggactgg      300

tggagttctg tcttctcaaa tcaaagttgc ccatcgccct gtaacacaac aaggtttgac      360

tggaatgaaa actgggacga aaggtcccca gaggcaaatt ttagacaaat cttactatct      420

tgggcttctt agaagtaaaa taagtgaact tacaactgaa gttaataaac ttcagaaggg      480

aatagaaatg tacaatcaag agaattcagt atatttgtca tatgaaaaga gggctgagac      540

tttagctgtt gagataaaag agcttcaagg acaactagca gactacaaca tgttggtaga      600

taaacttaat accaacactg aaatggaaga agtaatgaat gattacaata tg              652


<210> 4010
<211> 695
<212> DNA
<213> Homo sapiens

<400> 4010
ggcgaacgaa acgcggagct cgggagcgac ccggcggggc caggcacggg cagaagggcc       60

aagagggcca cagagggtca ccatgaagtt caatcccttc gttacctcgg accgcagtaa      120

aaaccgcaaa cgtcacttca atgccccctc acacgtgcgc aggaagatca tgtcatcccc      180

gctctccaag gagctgcggc agaagtacaa tgtccgctcc atgcccatcc gcaaggacga      240

cgaggtccag gtagttcgag gacactacaa aggtcagcaa attggcaagg tagtccaggt      300

gtacagaaag aaatatgtca tctacatcga gcgggtgcag cgtgagaagg ccaacggcac      360

aactgtccac gtgggcattc acccaagcaa ggtggttatc accaggctaa aactggacaa      420

ggatcggaaa aaaattcttg aacgcaaagc caagtctcga caagttggaa aagagaaagg      480

caaatataaa gaagaactta ttgagaaaat gcaggaataa atagaacctg ttgtgcaacc      540

acggtttaac cggagatttt gaggctaggg tgtgtttctt tcgaactttt cggaatgtct      600

ggaacatttc atttcctgtt ttgttacctg tgcctctgta aatctacttt tgcaatttta      660

agtaataatt ttatgaataa aaatgggaaa tgctt                                 695


<210> 4011
<211> 4532
<212> DNA
<213> Homo sapiens

<400> 4011
ggaacctcgg ctcccgggaa gccccgagcc tgggggaacc ctgggcaccc tgtgaaccct       60

gtggtctgca ctggctgccc tgctgctgtc gcggggctgc gggcggacga cctgagcccg      120

agctccgagg gcccggagcg gggcgccagg gcctagggtc gcgggggcca ggggcgcgcc      180

agggtggctg agagagcgaa atgtcatcag tgcagtcaca acaggagcag ttgtcccagt      240

cagatccatc tccgtcacca aactcatgta gttcctttga gctaatagac atggatgctg      300

gcagcttgta tgaaccagtt tctccccatt ggttttattg taagataata gattctaagg      360

agacatggat tcctttcaac tctgaggatt cacagcagct ggaagaggca tatagctctg      420

gaaaaggttg taatgggaga gttgttccta ctgatggggg cagatatgat gttcatttgg      480

gggagaggat gcggtatgct gtatactggg atgaactggc atcggaagtg agacgatgta      540

cgtggtttta caagggggac aaagacaata agtatgttcc ctactcggag agcttcagcc      600

aagttttaga ggaaacttac atgcttgctg taactttgga tgaatggaaa aagaaactgg      660

aatctcccaa cagagaaatt attattttac acaatccaaa gcttatggtg cattaccagc      720

cagttgcagg gtctgatgat tggggttcaa cacccacgga gcagggtcga ccaagaactg      780

tgaagagagg agttgagaac atctctgttg acattcattg tggagaacct ttacaaatag      840

atcacttggt ttttgtagtc catgggattg gaccagcttg tgatctccgc tttcgaagca      900

ttgtacagtg tgttaatgat tttcgcagtg tttccttgaa cttgctacag acacatttta      960

agaaagccca agaaaatcag cagattggga gggtagaatt tcttccagtc aactggcaca     1020

gtcctttgca ttctactggt gtggatgtag atctgcagcg aataaccctg cccagcatta     1080

accgcctcag gcacttcacc aatgacacaa ttctggatgt cttcttctac aatagtccca     1140

cctactgtca gactattgtg gacacagttg cttctgaaat gaaccgaata tacacacttt     1200

ttctacagag gaaccctgat ttcaaagggg gtgtatccat tgctggtcat agtttaggtt     1260

cgcttatatt gtttgatatc ctaacaaatc agaaagattc tttgggggat attgacagtg     1320

aaaaggattc gctaaatatt gtaatggatc aaggagatac acctacacta gaggaagatt     1380

tgaagaaact tcagctctct gaattctttg atatctttga gaaggagaaa gtagataagg     1440

aagctctggc tttatgtaca gaccgagatc ttcaggaaat aggaattcct ttaggaccaa     1500

gaaagaagat attaaactat ttcagcacca gaaaaaactc aatgggtatt aagagaccag     1560

ccccgcagcc tgcttcaggg gcaaacatcc ccaaagaatc tgagttctgc agtagcagta     1620

atactagaaa tggtgactat ctggatgttg gcattgggca ggtgtctgtg aaataccccc     1680

ggctcatcta taaaccagag atattctttg cctttggatc tcccattgga atgttcctta     1740

ctgtccgagg actaaaaaga attgatccca actacagatt tccaacgtgc aaaggtttct     1800

tcaatattta tcaccctttt gatcctgtgg cctataggat tgaaccaatg gtggtcccag     1860

gagtggaatt tgagccaatg ctgatcccac atcataaagg caggaagcgg atgcacttag     1920

aactgagaga gggcttgacc aggatgagta tggaccttaa gaacaacttg ctaggttcgc     1980

tgcggatggc ctggaagtct tttaccagag ctccataccc tgccttacaa gcttcagaaa     2040

caccagaaga aactgaagca gaacctgaat caacttcaga gaagcctagt gatgttaaca     2100

cagaagagac ctctgtggca gttaaagaag aagtcctgcc tatcaatgtg gggatgctga     2160

atggaggcca acgcattgac tatgtgctac aggagaagcc tattgaaagt tttaatgagt     2220

atttatttgc tttacaaagc catctatgct actgggagtc tgaagataca gtattgctcg     2280

tcctcaaaga gatctaccaa acccagggta tcttccttga tcagccttta cagtaaaaat     2340

gacccatcta tggctgctta atacggacat tgagggatcc ttccccagaa aatccacctg     2400

tttgttgctg caattttcct ctcctcagct gcgtcatttc ctgcatgttg cctgccactt     2460

actcaccact ggggtctttg gaagataatc ttcctctttg gaaatgaatg gaaaagcaaa     2520

aggccctatt acttttaacc actggcttca tataaacact tgccattttt ttctgcatag     2580

ctgggggtgg tttgtgtctt taattctttg atgatagttt atagttgcca cactttattg     2640

attagtactt gacagggtgt aaagcctatt ttgggtttga tttgttttgg gtggggtaga     2700

catgttttta aggaacttat tgcttatctt tagaaaatgt tctagtttgg aaacagattc     2760

ttgagattca gaaggcattt tggagtacac ttatctcttg tttgtgttga actgaaggct     2820

aagtctcagt ggacatggaa aagacttttg ggtgatttat ttttgaacct gcatttcttt     2880

cttatgtgta gtgtatgaag aaagactaga atgtagcttt aaaaaagtgt tgtttactct     2940

cttagaactg acagacttat tgccagaaat cactgatgtt cattgttttt gcaactgttt     3000

gagctgctgt aagagtctaa agttgacaag ttagttcatg ttaggtgcat ctttataaag     3060

caaagatgtt gtatatccta ggcctccctt ttatatttga tagaagttat ttgctaatag     3120

cttctattct tacgttgaaa atagttgtaa aagctgatga acctgaaatt gtgtagcctc     3180

tacaggctgc tgaggttcta aataaaacct tttagtggtg cctttatggt gaaacagaat     3240

ttgtcacctg ccatttctac ttgagctaag gtagtattgt gtatcctctt tccttcttag     3300

gtatccataa tccacaaagc atatttaaaa ggctcttggc acgggcagca ttggttgagc     3360

aggtaggttt ggctaggggg aaatgtttaa cttgttctga aagaaaaact tatgtctgta     3420

gggtccaaga aacagctatt ccagagtcag tgtcagctga gtctggaaca tatgaagtga     3480

ggtttacttc taagaacaca agtgactgca cactaatttt gtcaaggcat cttttcacta     3540

ctttgctgta gatttttctt cttcattggt cagtttgtca ttgtctttgt agttctcttt     3600

atgataatcc tttatacttg ctctcagatt ccacaggcct ctgtttatag agtggcaaag     3660

gcaggcgagc tgtggtttat tgtttataaa tttttttata aatgttatgg tattcaaagc     3720

cactgacatt taatatttac tgaagccatt ccttagacag cagtggtctt tatccctttc     3780

tggaaagaaa aggaaaatga agggtaatta ctgtcaccat ggagattgta gaggtaaggt     3840

tggggtatag gtcaggcctg gcctttcttt gtcatctgct tatagtctag tgctaagtat     3900

gccactaagt ttcagatata tggaatactt tattttttta aaggtatata aactctgagt     3960

tattgagaat taagtattca ctgtatatta aggggaagct tttgccaagt tgtggtcttc     4020

aaatttatgt ttactcttcc tattggcaga ataggtgcta tttaagagta aaccaaagga     4080

taagcagagg gagtccctat aaccaaagat ggacagcata gccctggata gccagataaa     4140

ccactctttg tattaagaaa tgtttctttc ctagtggtga ggggtgggta actgtgaaag     4200

agctttatat cttgtctatt catggtatta tagctgtata ttcccaggat gataagcttg     4260

attgaaatcc tgtatttagt catatattat ttgcgctgct tcatttgtat catgtgcaat     4320

ctctagacca accctatttt taaactctgg tacagcatca ttttgtacat attcccagct     4380

gcagaactag tatcacttat ctcagcaaaa gagattgttt gcatggaaag attaatagca     4440

ctgattagat ttctaatatt ttgcattttt gaaatgtttg ttttctacgt gattatattt     4500

aaaactttag taaatactaa catgaaacca ta                                   4532


<210> 4012
<211> 703
<212> DNA
<213> Homo sapiens

<400> 4012
gcgaggagtc gctcgggcac ttattgagcg ccgactgtct acgggcggcc ggggacagtc       60

ttgcactgtt tcctaggctg gagtgcagtg gcacaatcac agctcactgc agccttgact      120

tccccaggct caagccattc tcctacctca gcctcccaag cagttgggac cacaggtgat      180

gggcagaggc ttcagtgtcc ccttcgcctc cgcaggagag gagaggcagc agcatggcga      240

gtgtcctgtc ccgacgcctt ggaaagcggt ccctcctggg agcccgggtg ttgggaccca      300

gtgcctcgga ggggccctcg gctgccccac cctcggagcc actgctagaa ggggccgctc      360

cccagccttt caccacctct gatgacaccc cctgccagga gcagcccaag gaagtcctta      420

aggctcccag cacctcgggc cttcagcagg tggcctttca gcctgggcag aaggtttatg      480

tgtggtacgg gggtcaagag tgcacaggac tggtggagca gcacagctgg atggagggtc      540

aggtgaccgt ctggctgctg gagcagaagc tgcaggtctg ctgcagggtg gaggaggtgt      600

ggctggcaga gctgcagggc ccctgtcccc aggcaccacc cctggagccc ggagcccagg      660

ccctggccta caggcccgtc tccaggaaca tcgatgtccc aaa                        703


<210> 4013
<211> 610
<212> DNA
<213> Homo sapiens

<400> 4013
tgtaagatta tatctttttc ctaacgactc ataattaatc tgaattaata aatgcgtttt       60

cagagcaagt aataggttat tattatggag atcttgccaa gagatctcaa agttggtcac      120

ctggacagtc agtactgaaa gataaaaagg gctctgaaat gaagctttta agtagattta      180

gggaattgta ctcacatctg cttatcttta aatcatttta ttctcttgta tatggtcttg      240

cattgcctca gacataaatg agcatattct gatgtactct ttggatctga actcatcttc      300

acagatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag ttgatgtgga      360

aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa tggatgatga      420

aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa aaaaggtcat      480

tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg agaacaaaga      540

aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg accaaggaac      600

actttttgaa                                                             610


<210> 4014
<211> 3832
<212> DNA
<213> Homo sapiens

<400> 4014
ggggtcgagt cagtgccgtt tgcgccagtt ggaatcgaag cctcttaaaa tggcagatga       60

tttggacttc gagacaggag atgcaggggc ctcagccacc ttcccaatgc agtgctcagc      120

attacgtaag aatggctttg tggtgctcaa aggctggcca tgtaagatcg tggagatgtc      180

tgcttcgaag actggcaagc acggccacgc caaggtccat ctggttggta ttgacatctt      240

tactgggaag aaatatgaag atatctgccc gtcaactcat aatatggatg tccccaacat      300

caaaaggaat gacttccagc tgattggcat ccaggatggg tacctatcac tgctccagga      360

cagcggggag gtaccagagg accttcgtct ccctgaggga gaccttggca aggagattga      420

gcagaagtac gactgtggag aagagatcct gatcacggtg ctgtctgcca tgacagagga      480

ggcagctgtt gcaatcaagg ccatggcaaa ataactggct cccaaggtgg cagtggtggc      540

agcagtgatc ctccgaacct gcagaggccc cctcccccag cctggcctgg ctctggcctg      600

gtcctaggtt ggactcctcc tacacaattt atttgacgtt ttattttggt tttccccacc      660

ccctcaatct gtcagggagc ccctgccctt cacctagctc ccttggccag gagcgagcga      720

agccatggcc ttggtgaagc tgccctcctc ttctcccctc acactacagc cctggtgggg      780

gagaaggggg tgggtgctgc ttgtggttta gtcttttttt tttttttaaa ttcaatctgg      840

aatcagaaag cggtggattc tggcaaatgg tccttgtgcc ctccccactc atccttggtc      900

tggtcccctg ttgcccatag ccctttaccc tgagcaccac ccaacagact ggggaccagc      960

cccctcgcct gcctgtgtct ctccccaaac ccctttagat ggggagggaa gaagaggaga     1020

ggggagggga cctgccccct cctcaggcat ctgggaaggg cctgccccca tgggctttac     1080

ccttccctgc gggctctctc cccgacacat ttgttaaaat caaacctgaa taaaactaca     1140

agtttaatat gaaaaaaaaa aaaaaagaaa gaaagacgtg taaaatgcca agaactctag     1200

gaaacaggga caaaaacact tcaaagagaa agttcatgca cttgtttctg accacccagg     1260

gcacccttca gcacacgctg tctggagtgg cctgaagcaa ggagtgtctt gtgaggtgca     1320

gaggatgcaa tgggagcagg gtcctgtccc caccctaaag gagttcacag tttaacgcaa     1380

atgagaagcc agtgaggaca tcactactcc tgctgtgaac ttgggaacta gaaacacaaa     1440

acctgagtct ggagggaagc taaggaagca ttctgctctg gagtagacat gagtgcgtgt     1500

gaagcttctg atctcccatg agagcaatgg ggacatgggg cagaatctaa aacccatgac     1560

tgaaagcacc aaattgctaa aatggcaata aagagacatg aggccaagat ggagaagaag     1620

gaacccagga cgagggtcag cctcacattt ggggctcatt tccctcagtt tcctcactga     1680

atttcagaag ggactaactg agatgcaaag aagcagagca gcttttgcac catgtggagg     1740

actagatgga aaacaagtag actgagggtc tgctagtgaa ggtgacccct actgaagtcc     1800

actggctttg gttgggaccc agaagagtca cacgccagga atagaggtgg acaggaaaca     1860

ccctgacttt tgtagggact gaacctcact gataacctca attgcggatg gtatggaggg     1920

tgtctaggtg tgctaggacc cctgcccatt ccccagaaat agactcccat cttttctaca     1980

gcaagataac gtgctagtag gcctcaattc attgctaaat atttttaacg agtgtcttac     2040

atttagccaa aaagactagt catgtggcag gaaaaataca atgtcatatg accaaaagct     2100

aaaagactgt gaaaatgaat ccagaggtga cccaagcatt gaatttaaca atgccagtac     2160

ctggacctcc gcttgcccct aaaacattac aatcaagaat gtaggaaggg aaaggaaaca     2220

cgaagattaa tcaagcagga aggacaagct cagttttgca cccactgaat ttgccacaaa     2280

tattgtggaa aatattctcg gggacattgc agttgtctac tttggttggc acatggttca     2340

tacaacagtg tttgtgtcag tgaacatctt actcttcctc ggcagtcttt ctttgcccag     2400

agatttcgca atgactgttg accttcatca tcaccttttg gactttggct tgcactttag     2460

cttctgtaga tctccatgat gtaaagaagt attttaggtc cattttaatt cctgcaaagg     2520

ataaaatcct tctatttgtg tgcatataag tggacctgag cccttggtta gggtgtagag     2580

aggagaaggg gagaaacctg agggccagaa gctgttcttt cccttaaaag ggcaaactca     2640

tttccacact atggggactc tgacagatag cataccttcc tgtctatggc tattggacct     2700

gcaggctttc ccctgtaaat ccgtgttctg tcattgacat tttgtgactg taagacagac     2760

ttgagataag acatctagaa aacaataatt gaacaatgat gtgaatatat ttcacacaac     2820

tgaactgtac atttcaacaa ggttaagatg gtaattatca cgttatacat tttttaccgc     2880

aggttaaaat gtttcacagg ttgaaaggaa agcaactacc ttcagttctc tgagttcaag     2940

aatttgtaac atttcacccc ctgctccttc ctgatcttct gtggagcatc ttttttccat     3000

ccatgctcta ctcagagccc actttccctt ccctgacacc agcttcactg aggctggttg     3060

gaacctaaca caaaacattc tcagtaatga ctgaattccc acaaagaatt ccatatagac     3120

tgcatatgag ttgaatcttc taagacatga aatatttgtt ctcttcttgg ctaatatgca     3180

atgcaaatcc tgttgcagat gtacgtcata tacctctgaa attcctgatg tattcaatga     3240

aataacatct ttaaagttct gtgtagaatg ttttttttct gatttcttca catacgatag     3300

aaaaaaaaac ccaaaaaaac atgtactagg atttcaatag aagcaatggg tgatctaaaa     3360

agatgaaaga gcaaccgcat gcgccctaca gctaccgcta gattttatgg ggaaagcagc     3420

tggcccagtt tgcagctagg agaaatgtca aacacatgaa gaaatgagaa gcaaagaaaa     3480

accatgaggc atgaacattt catggcaatc acgatgtcct ggtttgtgag ataatgggat     3540

agaggagtag aaaacaagga gaaagatgag aaggtacaaa gtggttcaag tcaaacagct     3600

caactgaact tttcttaatg gaatatttaa aaagtggtac attaaaaaac ttcccccagt     3660

tcacatcaaa aattctctct tcaggactaa gttgggtaga gactgttcaa tgtgcctaga     3720

tatcttcaga acttatatat tttctgtttt ctacgtatgt tgaagggcag tgccaaatga     3780

tgtgtaatta tctaggttgt aaaaataaaa catactcccc cttcccttga gg             3832


<210> 4015
<211> 807
<212> DNA
<213> Homo sapiens

<400> 4015
attacgagat tggcttggat tctgtcggat ggacttgggg ctagctgcgg cggggctggg       60

taagaaaata ttgttagaac ttgcgggcga cggggagttg gggaacctga gaaaatgagt      120

cgaaggctcc taattattgg atatatcttc acgggggtga tgagccctca ggtgttgagg      180

gagcgaggac gggggaccga aaagccactg tcctgagacc cattcatggc actcgtgccc      240

tgccaggcca ggcctgcgtc ttcagggaaa cagtcgggat aactatgaga gtgtcgcctt      300

tgtggcggtg cctcgaagac cttgagcaat ccccggactg cgagcaggga aagctgcttc      360

cagtacccaa attgacagac tgtatttcct cgccagaaaa atttacttga gcttcagttt      420

ttcctgttaa gtcgagatga tccgacttca gtggggtatc atgcgggtat aaatgaaaac      480

atctatagga ggccagataa ccatgtcagc cacagttgta gatgcagtta atgctgcacc      540

cctatcgggg tccaaagaaa tgagtttgga agaaccaaag aagatgacca gagaggactg      600

gagaaagaag aaggagctag aagaacagcg aaaattgggc aatgctcctg cagaagttga      660

tgaagaagga aaagacatca acccccatat tcctcagtat atttcttcag tgccatggta      720

tattgatcct tcaaaaagac ctactttaaa acaccagaga ccacaaccag aaaaacaaaa      780

gcagttcagc tcatctggag aatggta                                          807


<210> 4016
<211> 3321
<212> DNA
<213> Homo sapiens

<400> 4016
acttccggtg cttgccctgc ccatccccgt ggcgggggcg tggccatggc gggggcgctc       60

cggcgggggc gggccctggg ctcccgccct tcgggtccca cagtttccag ccgccgctct      120

cctcagtgcc cggtggccca ggagggcctg ggagcccgaa gccgtccccg agtcgctcct      180

aggtcactgg cgcgatgcgg gccgtcctct cggctgatgg gttggaagcc cagcgaggct      240

agaggccagt cccaaagttt ccaggcatca gggctgcagc ccaggagcct caaggcggcc      300

cggcgggcga ctggacggcc ggacaggtcc cgagcagccc ggcccaccat ggacccctct      360

gcccacaggt cccgagcagc cccgcccaac atggacccag acccccaggc gggcgtgcag      420

gtgggcatgc gggtggtgcg cggcgtggac tggaagtggg gccagcagga cggcggcgag      480

ggcggcgtgg gcacggtggt ggagcttggc cgccacggca gcccctcgac acccgaccgc      540

acagtggtcg tgcagtggga ccagggcacg cgcaccaact accgcgccgg ctaccagggc      600

gcgcacgacc tgctgctgta cgacaacgcc cagatcggcg tccggcaccc caacatcatc      660

tgtgactgct gcaagaagca cgggctgcgg gggatgcgct ggaagtgccg tgtgtgcctg      720

gactacgacc tctgcacgca gtgctacatg cacaacaagc atgagctcgc ccacgccttc      780

gaccgctacg agaccgctca ctcgcgccct gtcacactga gtccccgcca gggcctcccg      840

aggatcccac taaggggcat cttccaggga gcgaaggtgg tgcgaggccc cgactgggag      900

tggggctcac aggatggagg ggaagggaaa ccgggccgtg tggtggacat ccgtggctgg      960

gatgtggaga caggccggag tgtggccagc gtgacgtggg ctgatggtac caccaatgtg     1020

taccgtgtgg gccacaaggg caaggtggac ctcaagtgtg tgggcgaggc agcgggcggc     1080

ttctactaca aggaccacct cccaaggctc ggcaagccgg cggagctgca gcgcagggtg     1140

agtgctgaca gccagccctt ccagcacggg gacaaggtca agtgtctgct ggacactgat     1200

gtcctgcggg agatgcagga aggccacggc ggctggaacc ccaggatggc ggagacgggc     1260

accgtgcatc gtatcacgga ccgcggggac gtgcgcgtgc agttcaacca cgagacgcgc     1320

tggaccttcc accccggggc gctcaccaag caccactcct tctgggtggg cgacgtggtc     1380

cgggtcatcg gcgaccttga cacagtgaag cggctgcagg ctgggcatgg cgagtggacg     1440

gacgacatgg cccctgccct gggccgcgtc gggaaggtgg tgaaagtgtt tggagacggg     1500

aacctgcgtg tagcagtcgc tggtcagcgg tggaccttca gcccctcctg cctggtggcc     1560

taccggcccg aggaggatgc caacctggac gtggccgagc gcgcccggga gaacaaaagc     1620

tcactgagcg tggccctgga caagcttcgg gcccagaaga gtgacccaga gcacccggga     1680

aggctggtgg tggaggtggc gctgggtaac gcagcccggg ctctggacct gctgcggagg     1740

cgcccagagc aggtggacac caagaaccaa ggcaggaccg ctctgcaagt ggctgcctac     1800

ctgggccagg tggagttgat acggctgctg ctacaagcca gggcgggcgt ggacctgccg     1860

gacgacgagg gcaacacggc actgcactac gcggccctgg ggaaccagcc cgaggccacc     1920

agggtgctcc tgagtgctgg gtgccgggcg gacgccatca acagcaccca gagcacagca     1980

ctgcacgtgg ccgtgcagag gggcttcctg gaggtggtgc gggccctgtg tgagcgcggc     2040

tgtgacgtca acctgcccga cgcccactcg gacacgcccc tgcactccgc catctcggcg     2100

ggcactggag ccagcggcat tgtcgaggtc ctcacggagg tgccaaacat cgatgttacc     2160

gccaccaaca gccagggttt caccctgctg caccatgcct ccctcaaggg tcacgcgcta     2220

gctgtgagaa agattctggc tcgggcgcgg cagctggtgg acgccaagaa ggaggacggc     2280

ttcacggcgc tgcatctggc tgccctcaac aaccaccgcg aggtggccca gatcctcatc     2340

cgggagggcc gctgtgacgt gaacgtgcgc aaccggaagc tgcagtcccc gctgcatctc     2400

gccgtgcaac aggcccacgt ggggctggtg ccgctactgg tggacgctgg gtgcagtgtc     2460

aacgccgagg acgaggaggg ggacacagcc ctgcacgtgg cgctgcagcg tcatcagctg     2520

ctgcccctgg tggctgatgg ggccgggggg gacccagggc ccttgcagct gctgtccagg     2580

ctacaggcct cgggcctccc cggcagcgcg gagctgacgg tgggcgcggc ggtcgcctgc     2640

ttcctggcgc tggagggcgc cgacgtgagc tacaccaacc accgcggtcg gagcccgctg     2700

gacctggccg ccgagggtcg cgtgctcaag gcccttcagg gctgcgccca gcgcttccgg     2760

gagcggcagg cgggcggggg cgcggccccg ggccccaggc aaacgctcgg gacccccaac     2820

accgtgacga acctgcacgt gggcgccgcg ccggggcccg aggccgctga gtgcctggtg     2880

tgctccgagc tggcgctgct ggtgctgttc tcgccgtgcc agcaccgcac cgtgtgtgag     2940

gagtgcgcgc gcaggatgaa gaagtgcatc aggtgccagg tggtcgtcag caagaaactg     3000

cgcccagacg gctctgaggt ggcgagcgcc gcccccgccc ccggcccgcc gcgccagctg     3060

gtggaggagc tgcagagccg ctaccggcag atggaggaac gcatcacctg ccccatctgc     3120

atcgacagcc acatccgcct cgtgttccag tgcggccacg gcgcatgcgc cccctgcggc     3180

tccgcgctca gcgcctgccc catctgccgc cagcccatcc gcgaccgcat ccagatcttc     3240

gtgtgagccg cgccgtccgc cgcgcccgag ctgccttcgc gtgcccccgc cctgtgtttt     3300

ataaaaagaa agattctcgg a                                               3321


<210> 4017
<211> 806
<212> DNA
<213> Homo sapiens

<400> 4017
agtcccggtt ccccgccatc agcacgacct gtgtgagagc acagggtatc tgggcagaag       60

gaaaactagg ggagcctcat ccagcgctgg agatggagaa gctttgggct tctcgacggc      120

gaggcacccg gggaacgggg agtcacttag aacctcaaag tagcctcggg cgagaacaag      180

cgaagcaatt ccaagctcta ccaggtcacg gagggcgcga aacccgcccc gcgctccggc      240

cggccggcag ggggcgcgcg ctccccgaac tcccgcgcac cgcggaggag gcggccctgg      300

cgcggggaag cagtgggaaa atcgcaagga agccggcgct gctctgaagg gagagtctgt      360

gcagtggcac ctgcgcgaag ctggccaaag cctgcccaga cggctcacct gtgcgggatg      420

gaacaaaagt ttgtttcgac gccggaccgc gtaagagacg atgatgttgg gcacggaagg      480

tggagaggga ttcgtggtga aggtccgggg cttgccctgg tcttgctcgg ccgatgaagt      540

gcagaggttt ttttctgact gcaaaattca aaatggggct caaggtattc gtttcatcta      600

caccagagaa ggcagaccaa gtggcgaggc ttttgttgaa cttgaatcag aagatgaagt      660

caaattggcc ctgaaaaaag acagagaaac tatgggacac agatatgttg aagtattcaa      720

gtcaaacaac gttgaaatgg attgggtgtt gaagcatact ggtccaaata gtcctgacac      780

ggccaatgat ggctttgtac ggctta                                           806


<210> 4018
<211> 584
<212> DNA
<213> Homo sapiens

<400> 4018
acttattgag cgccgactgt ctacgggcgg ccgggggcct gagccgcgcc ttgctgctgg       60

gtctccactt gtggggaaga gagaactgga ccaggacagc gcgggaaact gacaatgcca      120

ctgcttgcta gctttgggat tttggacaaa taggtgatgg gcagaggctt cagtgtcccc      180

ttcgcctccg caggagagga gaggcagcag catggcgagt gtcctgtccc gacgccttgg      240

aaagcggtcc ctcctgggag cccgggtgtt gggacccagt gcctcggagg ggccctcggc      300

tgccccaccc tcggagccac tgctagaagg ggccgctccc cagcctttca ccacctctga      360

tgacaccccc tgccaggagc agcccaagga agtccttaag gctcccagca cctcgggcct      420

tcagcaggtg gcctttcagc ctgggcagaa ggtttatgtg tggtacgggg gtcaagagtg      480

cacaggactg gtggagcagc acagctggat ggagggtcag gtgaccgtct ggctgctgga      540

gcagaagctg caggtctgct gcagggtgga ggaggtgtgg ctgg                       584


<210> 4019
<211> 742
<212> DNA
<213> Homo sapiens

<400> 4019
cacgccgccg gccgccgttt agtcccagag atagaaaaaa gtagaggtag gagggcgcgg       60

cggctcacgc ctgtaatccc agcactttgg aaggccgagg cgggcggatc acgagagggt      120

caccatgaag ttcaatccct tcgttacctc ggaccgcagt aaaaaccgca aacgtcactt      180

caatgccccc tcacacgtgc gcaggaagat catgtcatcc ccgctctcca aggagctgcg      240

gcagaagtac aatgtccgct ccatgcccat ccgcaaggac gacgaggtcc aggtagttcg      300

aggacactac aaaggtcagc aaattggcaa ggtagtccag gtgtacagaa agaaatatgt      360

catctacatc gagcgggtgc agcgtgagaa ggccaacggc acaactgtcc acgtgggcat      420

tcacccaagc aaggtggtta tcaccaggct aaaactggac aaggatcgga aaaaaattct      480

tgaacgcaaa gccaagtctc gacaagttgg aaaagagaaa ggcaaatata aagaagaact      540

tattgagaaa atgcaggaat aaatagaacc tgttgtgcaa ccacggttta accggagatt      600

ttgaggctag ggtgtgtttc tttcgaactt ttcggaatgt ctggaacatt tcatttcctg      660

ttttgttacc tgtgcctctg taaatctact tttgcaattt taagtaataa ttttatgaat      720

aaaaatggga aatgcttcct aa                                               742


<210> 4020
<211> 446
<212> DNA
<213> Homo sapiens

<400> 4020
gttgcctgtg ggtgcccgcg aaccaacggt tagcggtggc aggggctgac tgagagcgtc       60

tgcttggttg ggaaaccaat tagaaaggag tgttctgcta gaaacagata atggattctg      120

aattaatgca tagtatagta ggaagctatc ataaacctcc agaaagagta tttgttccct      180

cattcaccca gaatgaacca tctcagaatt gccatcctgc aaacttagaa gttacctctc      240

ctaagatact tcatagccca aatagccaag ctcttatttt agccttaaaa actcttcagg      300

aaaaaattca tcgtttagag ctggagagaa cacaagctga agataacctg aacattcttt      360

ccagagaagc agcacagtat aagaaggcct tagagaatga aacaaatgag agaaatctgg      420

cacaccagga gctgataaag cagaaa                                           446


<210> 4021
<211> 578
<212> DNA
<213> Homo sapiens

<400> 4021
ttattgcgag gatggaggga ggcgcaggcg ttctcattca tagttctccc atcctgaaag       60

ttctgttcct cttttgtcca gaaactgggc cctcgtcaga ctgccttgcc ctgttcctga      120

ctcaggccaa ggcctgcagc cgggaagagg ttggggcggc gtgagttatg tgaaaagcgc      180

tcagaataca gtatgtcatg tggactccca ttattgtccc agttgtttag aaaatatgcc      240

atcggctgaa gccaaactaa aaaagaatag atgtgccaat tgttttgact gtcctggctg      300

catgcacacc ctctctactc gggccacgag catctccaca cagcttccag atgacccagc      360

caagaccacc atgaagaaag cctattacct ggcatgtgga ttttgtcgct ggacgtctag      420

agatgtgggc atggcagaca aatctgtagc tagtggcggt tggcaggaac ctgaaaatcc      480

tcacacacaa cggatgaaca aattgattga atattaccag cagcttgctc agaaagagaa      540

ggttgagcga gatcgcaaga aactggcacg acgtagaa                              578


<210> 4022
<211> 770
<212> DNA
<213> Homo sapiens

<400> 4022
gcttccgcgt tccctgcaca aaatgccggg cgaagccaca gaaaccgtcc ctgctacaga       60

gcaggagttg ccgcagtccc aggctgagac agggtctgga acagcatctg atagtggtga      120

atcagtacca gggattgaag aacaggattc cacccagacc accacacaaa aagcctggct      180

ggtggcagca gctgaaattg atgaagaacc agtcggtaaa gcaaaacaga gtcggagtga      240

aaagagggca cggaaggcta tgtccaaact gggtcttcta caggttacag gagttactag      300

agtcactatc tggaaatcta agaatatcct ctttgtcatc acaaaactgg acgtctacaa      360

gagccctgct tcggatgcct acatagtttt tggggaagcc aagatccaag atttatctca      420

gcaagcacaa ctagcagctg cggagaaatt cagagttcaa ggtgaagctg tcggaaacat      480

tcaagaaaac acacagactc caactgtaca agaggagagt gaagaggaag aggtcgatga      540

aacaggtgta gaagttaaag acgtgaaatt ggtcatgtca caagcaaatg tgtcgagagc      600

aaaggcagtc cgagctctga agaacaacag taatgatatt gtaaatgcga ttatggaatt      660

aacagtgtaa ccatctgaaa gcaacttttt ttggtgtctc aaaggagtaa ctgcagcttg      720

gtttgaaatt tgtactgttt ctatcataaa taaagttatg acttcttgct                 770


<210> 4023
<211> 568
<212> DNA
<213> Homo sapiens

<400> 4023
tttcttgcaa actttgtggc acgttttctg ggaagaaaaa actaggatcg tgtaatatta       60

aaaaataaat cgagaggctt tttttttttg ctctccatat tattaagctg catggactga      120

gaggaggcca gataaccatg tcagccacag ttgtagatgc agttaatgct gcacccctat      180

cggggtccaa agaaatgagt ttggaagaac caaagaagat gaccagagag gactggagaa      240

agaagaagga gctagaagaa cagcgaaaat tgggcaatgc tcctgcagaa gttgatgaag      300

aaggaaaaga catcaacccc catattcctc agtatatttc ttcagtgcca tggtatattg      360

atccttcaaa aagacctact ttaaaacacc agagaccaca accagaaaaa caaaagcagt      420

tcagctcatc tggagaatgg tacaagaggg gtgtaaaaga gaattccata attactaagt      480

accgcaaagg agcatgtgaa aattgtgggg ccatgacaca caaaaagaaa gactgctttg      540

agagacctag gcgagttgga gccaaatt                                         568


<210> 4024
<211> 699
<212> DNA
<213> Homo sapiens

<400> 4024
gtcttgcact gtttcctagg ctggagtgca gtggcacaat cacagctcac tgcagccttg       60

acttccccag gctcaagcca ttctcctacc tcagcctccc aagcagttgg gaccacagga      120

gaggagaggc agcagcatgg cgagtgtcct gtcccgacgc cttggaaagc ggtccctcct      180

gggagcccgg gtgttgggac ccagtgcctc ggaggggccc tcggctgccc caccctcgga      240

gccactgcta gaaggggccg ctccccagcc tttcaccacc tctgatgaca ccccctgcca      300

ggagcagccc aaggaagtcc ttaaggctcc cagcacctcg ggccttcagc aggtggcctt      360

tcagcctggg cagaaggttt atgtgtggta cgggggtcaa gagtgcacag gactggtgga      420

gcagcacagc tggatggagg gtcaggtgac cgtctggctg ctggagcaga agctgcaggt      480

ctgctgcagg gtggaggagg tgtggctggc agagctgcag ggcccctgtc cccaggcacc      540

acccctggag cccggagccc aggccctggc ctacaggccc gtctccagga acatcgatgt      600

cccaaagagg aagtcggacg cagtggaaat ggatgagatg atggcggcca tggtgctgac      660

gtccctgtcc tgcagccctg ttgtacagag tcctcccgg                             699


<210> 4025
<211> 492
<212> DNA
<213> Homo sapiens

<400> 4025
ctttcatttt cagccctgct ctttaaatac tagacatacc gtctggcgca tgtcgaggcg       60

tgtattattt tgatccagtg cgcgtgccgt atgtgacttg gcttggcttc ccctgaaagc      120

agcggctgtg gggagttgat tcggaagtga agggccctgg gcgacccggc gagtagaggc      180

aacaccaaca ctcctcctta gcgaggggtc tccccgccgc ggtggctgcc cggccccaag      240

gacaggaggg atttgtgcac tgactcctga ccccgtcctc cagcgctgct ctgaagggag      300

agtctgtgca gtggcacctg cgcgaagctg gccaaagcct gcccagacgg ctcacctgtg      360

cgggatggaa caaaagtttg tttcgacgcc ggaccgcgta agagacgatg atgttgggca      420

cggaaggtgg agagggattc gtggtgaagg tccggggctt gccctggtct tgctcggccg      480

atgaagtgca ga                                                          492


<210> 4026
<211> 575
<212> DNA
<213> Homo sapiens

<400> 4026
cttgcgccct gaggcggttt ccgttcccgg acgtttggac tctgtcctgg agaaggggaa       60

ggaaaaagta agacgtagaa gtacactgag acttcgtcac acataaaaca agcacgacaa      120

agaaagaggg cgcgaaggga ctcctggaag aaattgagtc tacatttaag atcaccctaa      180

aagtagtgac ggcctcttca ttactccaaa ccccagattt aagtcggtag gacgtcttcg      240

cgttgacttg tggggaatgt agtttcgatg ctgccggcgc gttttgtttg cgacagaaac      300

tacaaccccc aggggccacc gcgacgttgc ctgtgggtgc ccgcgaacca acggttagcg      360

gtggcagggg ctgactgaga gcgtctgctt gtgcctggta cctagtacaa acttaataaa      420

tgtgtgacgc aagaataaag gaatgaatga atggaagaat gatataatgc cacagaactt      480

tcaaagataa tggattctga attaatgcat agtatagtag gaagctatca taaacctcca      540

gaaagagtat ttgttccctc attcacccag aatga                                 575


<210> 4027
<211> 1287
<212> DNA
<213> Homo sapiens

<400> 4027
actcggcggt ggcgtccgtg ttgttattgt ggtggtagcg gcgtctggct gctgcggacc       60

ccgccgagtc ctagcgcctg gcctgcgcgc cgctgcccgc gccacaggat taatttattt      120

ttggaaatca agtgcaatat tggaagccat ttctactaat tttatttcac ttttaaattt      180

atgatttgat ttgaatacta tcatgggagg agctgtgagt gctggggaag ataatgatga      240

cttaattgat aatttaaaag aagctcagta tattcgtact gaaagagtgg agcaagcctt      300

cagagcgatt gatcgtggag attactattt ggaaggctac agagacaatg cttacaaaga      360

cttagcctgg aagcatggaa acatccactt gtcagcacct tgcatttatt ctgaagttat      420

ggaagcattg aaacttcaac caggattgtc ttttcttaac ctgggaagtg gaaccggata      480

tttaagtaca atggtgggct taattttagg tccttttgga ataaatcatg ggattgagct      540

tcattcagat gtggtggaat atgccaagga aaaactggag agcttcatca aaaatagtga      600

tagctttgat aaatttgagt tctgtgaacc tgcatttgtt gttggtaatt gcctccagat      660

agcttctgac agtcatcagt atgatcgaat ttattgtgga gctggagtgc agaaagacca      720

tgaaaactac atgaaaatat tactaaaagt tggaggcata ttagtcatgc ctatagagga      780

tcagttaaca cagattatgc gaactggaca gaacacttgg gaaagtaaaa atatccttgc      840

tgtttcattt gctccacttg tgcaaccaag taagaatgat aatggcaaac cagattctgt      900

gggactccct ccctgtgctg tcaggaatct acaggacttg gctcgtattt acattcgacg      960

cacacttaga aatttcataa atgatgagat gcaggccaag gggattcctc aaagggctcc     1020

acccaaaagg aaaagaaaga gagttaaaca gagaattaac acttacgtat ttgtgggtaa     1080

tcagcttatt cctcagcctc tagacagtga agaggatgaa aaaatggaag aggataacaa     1140

agaagaggag gaaaaagatc acaatgaagc aatgaagcca gaggagccac ctcaaaattt     1200

actgagagaa aaaatcatga agctgcccct ccctgaatct ttaaaagctt acttgacata     1260

ttttagagac aaataactta gatcaag                                         1287


<210> 4028
<211> 1683
<212> DNA
<213> Homo sapiens

<400> 4028
cgccgcgctg cgacgctgta gtggcttcgt cttcggtttt tctcttcctt cgctaacgcc       60

tcccggctct cgtcagcctc ccgccggccg tctccttaac accgaacacc atgccttcaa      120

ttaagttgca gagttctgat ggagagatat ttgaagttga tgtggaaatt gccaaacaat      180

ctgtgactat taagaccatg ttggaagatt tgggaatgga tgatgaagga gatgatgacc      240

cagttcctct accaaatgtg aatgcagcaa tattaaaaaa ggtcattcag tggtgcaccc      300

accacaagga tgaccctcct cctcctgaag atgatgagaa caaagaaaag cgaacagatg      360

atatccctgt ttgggaccaa gaattcctga aagttgacca aggaacactt tttgaactca      420

ttctggctgc aaactactta gacatcaaag gtttgcttga tgttacatgc aagactgttg      480

ccaatatgat caaggggaaa actcctgagg agattcgcaa gaccttcaat atcaaaaatg      540

actttactga agaggaggaa gcccaggtag gtagcacaca gttttgtctt tgatcacatg      600

ctcttaaaaa gggagtaaca cctataacat gccagcaaaa gaggtgactg tatcaagtag      660

tcttgatact ttagggataa tatgtactta atgtgtctta aacatactct tactgttctg      720

tctttatgaa tctgaacact tagatgatac tgcattttaa gcataagaac aattagtttt      780

caatgagaag agctcttgtt aatgtattaa cagttactag ttttggcacc tgcaactttc      840

tgtatagacc atacatatct gacatcagaa aagcaggccc tagagagaag tatatactag      900

ggtactttag agcaacttaa tgaggggagg aaatgaaaga atagatcaga atgattttgt      960

tgacatgact acagactgaa ataatgtgaa tgaattaact gaatttgctc tgtcaacttt     1020

agtaaattgc ccattgcctt tgctttgttc ataatttcag cagggcagaa taaaaaccat     1080

gggaggcaaa gaaaggaaat ccggaaatat agtcttaacc tggtgttgtt ctaattttcc     1140

atctgttctt ctgactcaac tcactggcta tcgatgaatc agtaggtagt atttataagt     1200

cttaggaaag actactcaag ttaaggtact tccctatatc catctctttt aggtacgcaa     1260

agagaaccag tggtgtgaag agaagtgaaa tgttgtgcct gacactgtaa cactgtaagg     1320

attgttccaa atactagttg cactgctctg tttataattg ttaatattag acaaacagta     1380

gacaaatgca gcagcaagtc aattgtatta gcagaatatt gtcctcattg catgtgtagt     1440

ttgagcacag atcccaaacc ttacggccaa gtttcttcta gtatgatgga aagtttcttt     1500

tttctttgct ctgaataaaa ctgaactgtg ggttctctat aagtggcatt ttgggctttc     1560

cctctttttt gtaaagcaat gtctgcctag tttattgtcc agttaacttt agtgaccttt     1620

taaaagttgg cattgtaaat aaaacaactt gcaaaaaagt tttctggaat agaattaaca     1680

aaa                                                                   1683


<210> 4029
<211> 769
<212> DNA
<213> Homo sapiens

<400> 4029
gcgacgttgc ctgtgggtgc ccgcgaacca acggttagcg gtggcagggg ctgactgaga       60

gcgtctgctt gattcaggtt atgctttctg gccagaatac tgcataggtg atgttgcgtc      120

cttctccagg tttcatatcc agaggcacat ggtggccttc tacctctcac agacagagtc      180

tttctctgtc acccaggctg gagtacagtg gcacgatctc ggctccctgc aacgtccgcc      240

tcccgagttc aagtgattct cctgcctcag ccacccgagt agctgggtct acaggtgtgc      300

gccaccatgc ctggctaatt tttgtatttt taagagagac ggggtttcac catgctggcc      360

aggctggtct cgaactcctg acctcgtgat ccgcctgcct cagcccctca aagtgctagg      420

attagagata atggattctg aattaatgca tagtatagta ggaagctatc ataaacctcc      480

agaaagagta tttgttccct cattcaccca gaatgaacca tctcagaatt gccatcctgc      540

aaacttagaa gttacctctc ctaagatact tcatagccca aatagccaag ctcttatttt      600

agccttaaaa actcttcagg aaaaaattca tcgtttagag ctggagagaa cacaagctga      660

agataacctg aacattcttt ccagagaagc agcacagtat aagaaggcct tagagaatga      720

aacaaatgag agaaatctgg cacaccagga gctgataaag cagaaaaaa                  769


<210> 4030
<211> 501
<212> DNA
<213> Homo sapiens

<400> 4030
ggagccgggc cgcgggccgc gccgggaggg cgggcagggc cgcggccgct gcagcccgga       60

gctgagctag ccgtccgagc cgagccgtcc gagccgggga agccgggcgc gtgctgccgc      120

tcgtggcggg ccgaggtgat gggcagaggc ttcagtgtcc ccttcgcctc cgcaggagag      180

gagaggcagc agcatggcga gtgtcctgtc ccgacgcctt ggaaagcggt ccctcctggg      240

agcccgggtg ttgggaccca gtgcctcgga ggggccctcg gctgccccac cctcggagcc      300

actgctagaa ggggccgctc cccagccttt caccacctct gatgacaccc cctgccagga      360

gcagcccaag gaagtcctta aggctcccag cacctcgggc cttcagcagg tggcctttca      420

gcctgggcag aaggtttatg tgtggtacgg gggtcaagag tgcacaggac tggtggagca      480

gcacagctgg atggagggtc a                                                501


<210> 4031
<211> 802
<212> DNA
<213> Homo sapiens

<400> 4031
gctgtagtgg cttcgtcttc ggtttttctc ttccttcgct aacgcctccc ggctctcgtc       60

agcctcccgc cggccgtctc cttaacaccg aacaccacat aaatgagcat attctgatgt      120

actctttgga tctgaactca tcttcacaga tgccttcaat taagttgcag agttctgatg      180

gagagatatt tgaagttgat gtggaaattg ccaaacaatc tgtgactatt aagaccatgt      240

tggaagattt gggaatggat gatgaaggag atgatgaccc agttcctcta ccaaatgtga      300

atgcagcaat attaaaaaag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc      360

ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag      420

aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag      480

acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa      540

ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag      600

cccaggtacg caaagagaac cagtggtgtg aagagaagtg aaatgttgtg cctgacactg      660

taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa ttgttaatat      720

tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat attgtcctca      780

ttgcatgtgt agtttgagca ca                                               802


<210> 4032
<211> 729
<212> DNA
<213> Homo sapiens

<400> 4032
ggacatgtga ctctcccacc tcgtttcgtg gcagagccaa agagctgagc aaaaggagct       60

gctgcagctt gaagaaaaag ccacccctga aggctcctgc cagagccagg cttaccttct      120

ctccctcgag aatcttctcc cgaaggacca gcccagggaa gggaagcagc tgctctggac      180

tcactcaagt gtgtctcaca ccccttcctc ttccagcagc agctacctgg caactgaacc      240

catcatcacc acagccactc ctgcagctgc cacggtttct gccacctcta agatgtgccc      300

tggtaactgg ctttgggctt ctatgacttt tatggcccgc ttctcccgga gtagctcaag      360

gtctcctgtt cgaactcgag ggaccctgga ggagatgcca accgttcaac atcctttcct      420

caatgtcttc gagttggagc ggctcctcta cacaggcaag acagcctgta accatgccga      480

cgaggtctgg ccaggcctct atctcggaga ccaggacatg gctaacaacc gccgggagct      540

tcgccgcctg ggcatcacgc acgtcctcaa tgcctcacac agccggtggc gaggcacgcc      600

cgaggcctat gaggggctgg gcatccgcta cctgggtgtt gaggcccacg actcgccagc      660

ctttgacatg agcatccact tccagacggc tgccgacttc atccaccggg cgctgagcca      720

gccaggagg                                                              729


<210> 4033
<211> 1790
<212> DNA
<213> Homo sapiens

<400> 4033
gctagccgtc cgagccgagc cgtccgagcc ggggaagccg ggcgcgtgct gccgctcgtg       60

gcgggccgag gagaggagag gcagcagcat ggcgagtgtc ctgtcccgac gccttggaaa      120

gcggtccctc ctgggagccc gggtgttggg acccagtgcc tcggaggggc cctcggctgc      180

cccaccctcg gagccactgc tagaaggggc cgctccccag cctttcacca cctctgatga      240

caccccctgc caggagcagc ccaaggaagt ccttaaggct cccagcacct cgggccttca      300

gcaggtggcc tttcagcctg ggcagaaggt ttatgtgtgg tacgggggtc aagagtgcac      360

aggactggtg gagcagcaca gctggatgga gggtcaggtg accgtctggc tgctggagca      420

gaagctgcag gtctgctgca gggtggagga ggtgtggctg gcagagctgc agggcccctg      480

tccccaggca ccacccctgg agcccggagc ccaggccctg gcctacaggc ccgtctccag      540

gaacatcgat gtcccaaaga ggaagtcgga cgcagtggaa atggatgaga tgatggcggc      600

catggtgctg acgtccctgt cctgcagccc tgttgtacag agtcctcccg ggaccgaggc      660

caacttctct gcttcccgtg cggcctgcga cccatggaag gagagtggtg acatctcgga      720

cagcggcagc agcactacca gcggtcactg gagtgggagc agtggtgtct ccaccccctc      780

gcccccccac ccccaggcca gccccaagta tttgggggat gcttttggtt ctccccaaac      840

tgatcatggc tttgagaccg atcctgaccc tttcctgctg gacgaaccag ctccacgaaa      900

aagaaagaac tctgtgaagg tgatgtacaa gtgcctgtgg ccaaactgtg gcaaagttct      960

gcgctccatt gtgggcatca aacgacacgt caaagccctc catctggggg acacagtgga     1020

ctctgatcag ttcaagcggg aggaggattt ctactacaca gaggtgcagc tgaaggagga     1080

atctgctgct gctgctgctg ctgctgccgc aggcacccca gtccctggga ctcccacctc     1140

cgagccagct cccaccccca gcatgactgg cctgcctctg tctgctcttc caccacctct     1200

gcacaaagcc cagtcctccg gcccagaaca tcctggcccg gagtcctccc tgccctcagg     1260

ggctctcagc aagtcagctc ctgggtcctt ctggcacatt caggcagatc atgcatacca     1320

ggctctgcca tccttccaga tcccagtctc accacacatc tacaccagtg tcagctgggc     1380

tgctgccccc tccgccgcct gctctctctc tccggtccgg agccggtcgc taagcttcag     1440

cgagccccag cagccagcac ctgcgatgaa atctcatctg atcgtcactt ctccaccccg     1500

ggcccagagt ggtgccagga aagcccgagg ggaggctaag aagtgccgca aggtgtatgg     1560

catcgagcac cgggaccagt ggtgcacggc ctgccggtgg aagaaggcct gccagcgctt     1620

tctggactga gctgtgctgc aggttctact ctgttcctgg ccctgccggc agccactgac     1680

aagaggccag tgtgtcacca gccctcagca gaaaccgaaa gagaaagaac ggaaacacgg     1740

agtttgggct ctgttggcta aggtgtaaca cttaaagcaa ttttctccca                1790


<210> 4034
<211> 3616
<212> DNA
<213> Homo sapiens

<400> 4034
gacgcgcgac ggttcgtgcg tgcgtgcggg cggctgcgtc gggctgcagg agaagatggc       60

ggtctccaca ggagttaaag ttcctcgtaa ttttcgcttg ttggaagaac ttgaagaagg      120

acaaaaagga gtaggcgacg gtacagttag ctggggcctt gaagatgatg aagatatgac      180

acttacaagg tggacaggca tgattattgg gccaccaagg acaaattatg aaaacagaat      240

atatagcctg aaagtagaat gtggacctaa atacccagaa gctcctccgt cagttagatt      300

tgtaacaaaa attaatatga acggaataaa taattccagt gggatggtgg atgcccggag      360

cataccagtg ttagcaaaat ggcaaaattc atatagcatt aaagttgtac ttcaagagct      420

aagacgtcta atgatgtcca aagaaaatat gaagcttcca cagccaccag aaggacaaac      480

atacaacaat taattttagt ggatctcaaa cttgtcttaa atcaacaacc ttctactcat      540

gttaatgtct tgattaaata tcacaatgca aaatacacat taagtaaaag aattccagct      600

ggtaaacatg acctggacat ttgtaagaat atatttaata tatgtacacc cattatgttt      660

tcaggtaaca ggaggaaaaa tgcagcacaa ttttttttct cttgaaaggc actgtcattt      720

aaacataaac ctggagtact cgaaatagaa ttcaggttta caagatgaaa gcgtgtggag      780

aagtgtcaga tggcagtgga agcatgtgtg tttctaaaaa gtaaaaatct caagaaaaca      840

gaaatggcat gctttaccca tcttacttag tgaaagagag ctgcagttga aattgtttaa      900

aaagtagcag gtacaatgaa tattgtcaca gatgtgttaa tttttgaagc aatgtgggtg      960

ctgactacta gtagtatcaa aaatatgttc aggattgttt tgatacctgt atttataata     1020

aaaaatgttg gggggagttg atgaattcct gttaaaagct gttcttgtgt gttacatgta     1080

acagacatgg taaatatttg tttacagtct ttgtttaaca aaccatgcat ttaagtttaa     1140

gtgaagtcaa caaaaaggaa ataggtgtat ggatatgtga ttttgagatt aaagttagtc     1200

ttaaaatgta aataaaatgt gaaacgtgtc ctcagagact gtgccatttc tattatgttg     1260

atgtatatgt acagtacctt gccagggaag caaaaattgg aattattgta gcttttcatg     1320

tatacacact tttatttacc ctattttgtg tacttcttgt gaattataat ttgcagacta     1380

tttcagaaaa gaaattatct agtttaattt cttctttgga caaggagtcc taggtattat     1440

attttgagtt tgatttcacc agaaataata atattaaaaa gatctttgca ttctggcagt     1500

tcttttagga ttataggttg caaattatcc aaatatatat cccatttttt aaagcataat     1560

atctttttta gttgtttttc tgtgaagctt ttggttaata aatagggtca actaattgga     1620

gacttttctc ttccaattag ggcttttaat actaacaagg ataactttat tcattcctcg     1680

tattctctac tctaacaaat atgaactctg aagttgaaaa gtcatttatg ttccgctttc     1740

accaaagtga cgtgaggctt taggtcactg tttcacttca aagtactgga tccaaagctt     1800

tgttgaaaat gctgtttgat gaattcactg aagaatatag aaaggtggtc aggtaaagtc     1860

tacttttatt ttgtcaagct taataatttg tgtcatactt taccccagta tatataggca     1920

aaccaaaacc ttatcaaata ttaaattagt tgtttaaact ttgcttataa agtattggcc     1980

atgtggtggc tcatgccgct aatcccagca ctttgggagg ctgagacggg cagatcactt     2040

gaggtcagga gcttgagacc agcctggcca acatgatgaa accctgtctc tactaaaaat     2100

acaaaaaatt agccaggtgt ggtggtgggt acttgtagtc ccagctactc gggaggctgg     2160

gcaggagaac tacttgaaac tggcagacag aggttgcagt gccgagagcg caccactgct     2220

ccagcctggg caacagagca agactccatc tcaaaaaaaa aaaaaaaaag aaaaatatta     2280

ataattgacc ttggctgtat attaaaatag ttacttttat agtagagcac atttctcaaa     2340

catgccctga aaggctttta tcaagctcat ataaagttaa agctttgagc taccttttct     2400

tggccaataa agtcactgac agtttatgta aacattaatt tcaacatggc tgttgcattt     2460

taattatcaa aaatgtttaa aatgctttaa gatgacacat agagaacata cacatacata     2520

caaattagtg catttgtaat ttgttaaatt tgaaatgaac tattaccttg aaatatagtc     2580

tttaaaaatt tttaatggtt aaagattaaa ttgaatgaaa ctgtagtcta atggtaactg     2640

atgatctgaa tccgtctctc tgataacctc ctttccattt tgaaaatgtg tcttattata     2700

catggaagct agtaactacg tgaatgctgt tggcaggatg agggtctggg tacctcagtc     2760

tcttgtcctg tttccttccc ccaaatccac cattgtgaag ttgccaaccc cctgccgcct     2820

tcccctgcca agtacatgtt gtcagagtca gccctataat gttcatttcc cctcttgttt     2880

gtgggattat ggatctctgc agaaatctgc atgccaatta acccatttct aaagcagaat     2940

ccattttgca tgtcacaatc aagatgtact tggcaatcta agacacactg ggagactgta     3000

agaggaatta atatagaaaa gctcttaatt ataataacat ttggaagaaa tttttccttt     3060

gttttgtaaa gtggctaagg ttgtaggagt gtgtggtatt tattaccttt taaatgaact     3120

gtaaatttgc cttagaaatt tgtttaaaag gctagcaagt gagacccttg aggatgatca     3180

tatactaata aagattacca aaagaaactt cttgtcctgt taggtcagtg ttatgattta     3240

atggttttaa ttacttaacc aattttaaga attgacaatt tttaaaaata tttttttcta     3300

ccattctaaa gtaatgtctt ttgttgtggg tttatgtgta actacaggat tttggaacat     3360

aaacattttg aaggatagtc aatggtattt agtcttggat ataaaaatag agaaaattta     3420

tagctttatg ttattaaaat aatttatcac acagagtgat ttgaggtttt cgcagagtag     3480

atttgtttga ctcatggttt attagtctgg attacttaag aacaatatgt tgattttaat     3540

gttaattccc actaaatata taatattgat aaatacatgt gaaattaata ttgtttggaa     3600

aatgtagagg acacag                                                     3616


<210> 4035
<211> 2068
<212> DNA
<213> Homo sapiens

<400> 4035
ctgcacaggg agtttgtctt gtgcaaacaa tttccaaggc agcgttttct tccctgcctg       60

ggagtgcagg gctcagcgcc ttcactttgg aactgactca gagacctaaa gaagcccacc      120

tggccagcgg gaaggggggc cgccgccgcc tcccggtttt gggcagccct ggccagctcc      180

ctgtggcctt ggaggacttc caccgggcag gcgttcccat gatgccaggc taccaggcgc      240

gggggattcc tgcaggccgg cgctgctttt cttagaaccc cctttctaga aaagtacacc      300

tgggggtttt gcttcaaaga gaggagaggc agcagcatgg cgagtgtcct gtcccgacgc      360

cttggaaagc ggtccctcct gggagcccgg gtgttgggac ccagtgcctc ggaggggccc      420

tcggctgccc caccctcgga gccactgcta gaaggggccg ctccccagcc tttcaccacc      480

tctgatgaca ccccctgcca ggagcagccc aaggaagtcc ttaaggctcc cagcacctcg      540

ggccttcagc aggtggcctt tcagcctggg cagaaggttt atgtgtggta cgggggtcaa      600

gagtgcacag gactggtgga gcagcacagc tggatggagg gtcaggtgac cgtctggctg      660

ctggagcaga agctgcaggt ctgctgcagg gtggaggagg tgtggctggc agagctgcag      720

ggcccctgtc cccaggcacc acccctggag cccggagccc aggccctggc ctacaggccc      780

gtctccagga acatcgatgt cccaaagagg aagtcggacg cagtggaaat ggatgagatg      840

atggcggcca tggtgctgac gtccctgtcc tgcagccctg ttgtacagag tcctcccggg      900

accgaggcca acttctctgc ttcccgtgcg gcctgcgacc catggaagga gagtggtgac      960

atctcggaca gcggcagcag cactaccagc ggtcactgga gtgggagcag tggtgtctcc     1020

accccctcgc ccccccaccc ccaggccagc cccaagtatt tgggggatgc ttttggttct     1080

ccccaaactg atcatggctt tgagaccgat cctgaccctt tcctgctgga cgaaccagct     1140

ccacgaaaaa gaaagaactc tgtgaaggtg atgtacaagt gcctgtggcc aaactgtggc     1200

aaagttctgc gctccattgt gggcatcaaa cgacacgtca aagccctcca tctgggggac     1260

acagtggact ctgatcagtt caagcgggag gaggatttct actacacaga ggtgcagctg     1320

aaggaggaat ctgctgctgc tgctgctgct gctgccgcag gcaccccagt ccctgggact     1380

cccacctccg agccagctcc cacccccagc atgactggcc tgcctctgtc tgctcttcca     1440

ccacctctgc acaaagccca gtcctccggc ccagaacatc ctggcccgga gtcctccctg     1500

ccctcagggg ctctcagcaa gtcagctcct gggtccttct ggcacattca ggcagatcat     1560

gcataccagg ctctgccatc cttccagatc ccagtctcac cacacatcta caccagtgtc     1620

agctgggctg ctgccccctc cgccgcctgc tctctctctc cggtccggag ccggtcgcta     1680

agcttcagcg agccccagca gccagcacct gcgatgaaat ctcatctgat cgtcacttct     1740

ccaccccggg cccagagtgg tgccaggaaa gcccgagggg aggctaagaa gtgccgcaag     1800

gtgtatggca tcgagcaccg ggaccagtgg tgcacggcct gccggtggaa gaaggcctgc     1860

cagcgctttc tggactgagc tgtgctgcag gttctactct gttcctggcc ctgccggcag     1920

ccactgacaa gaggccagtg tgtcaccagc cctcagcaga aaccgaaaga gaaagaacgg     1980

aaacacggag tttgggctct gttggctaag gtgtaacact taaagcaatt ttctcccatt     2040

gtgcgaacat tttatttttt aaaaaaaa                                        2068


<210> 4036
<211> 748
<212> DNA
<213> Homo sapiens

<400> 4036
ctgcattgtt agatttgtga ttctgcactg ttcatttcag tactatctaa tataaaaatt       60

acatgtttaa atgttttata attaaaaatt gggctcaggt taaaatattt tcttttggag      120

ataccttttg ttgtggtctt gtcacaggaa gggtcctcta ctctgcatcc ttctccatta      180

agcagggaca actgcattat tggcaagcgc taagcaacat ggagaagcag acatgtttgt      240

gaatcgcaaa gtgaaatctg attctctcca actatggatg agtgagagta ggatatttca      300

gtggctggtt ttaaaacatg ctttactttt ttgcttcctt tgcctaacaa cctgtttgct      360

ttggggttgg cgacaattgt ctcagagaag ctgaatgaat attttaaccg atgtaatggg      420

tcataagtct ttgaacataa aatgggtgtg atgcatgttt taaatgccaa atgatacact      480

tttgggaaaa tatatgcgat ttgtaataca acacacctag aaaacttcag aggtgccata      540

agttaatagt gacatcaccg gattatgaat acttgagaag catgggcctt ttaaaagttg      600

tatgtgagtt ttaagaggcc ttgaattaat ctgtaccaga cataaatgag catattctga      660

tgtactcttt ggatctgaac tcatcttcac agatgccttc aattaagttg cagagttctg      720

atggagagat atttgaagtt gatgtgga                                         748


<210> 4037
<211> 2329
<212> DNA
<213> Homo sapiens

<400> 4037
gtggccagcg agggcagcgt tcgccgcccc tcaggccccg tcccggcgcc gcagccgcct       60

gcgtttcggt ttgtgagcag gcccggccgg gccaggagcg agagcgagac tctggagcgg      120

tcgccgccgc agtcgcccgg gccgggaaag gcgggcgatg cccccaaccg ccgctcgggc      180

catgtccgag gggcgcgcgt gttgtcgccg ccggggcgcc gtgcccgcct gtcgtccccc      240

gggcccagcc gctcgtccga ggcccgcgag gagctgcgcc gccacctcgt gggcctcatc      300

gagcgcagcc gggtggtgat cttcagcaag agctactgtc cccatagtac tcgggtgaaa      360

gaactctttt cttctttggg agtcgaatgt aatgtcttgg aacttgatca agttgatgat      420

ggggccaggg ttcaagaagt gctgtcagaa atcactaatc agaaaactgt gcccaatatt      480

ttcgtgaata aagtgcatgt aggtggatgt gaccaaactt tccaggcata tcagagtggt      540

ttgttacaga agctccttca ggaagatttg gcatatgatt atgatctcat catcatcggt      600

ggtggttctg gaggcctttc atgtgcgaag gaagctgcca ttttgggaaa gaaagttatg      660

gtgctagact ttgttgtccc gtcacctcag ggcacatcct ggggtcttgg tggcacttgt      720

gtaaatgtag gttgtattcc taagaaattg atgcatcagg ctgccctttt ggggcaggca      780

ttatgtgact caaggaaatt tggctgggaa tataatcaac aagtgaggca caactgggag      840

acaatgacaa aagcgattca gaaccacatc agctctctaa actggggcta caggttgtct      900

ctgagggaaa aggctgtggc ctatgtcaat tcctatggag aatttgttga acatcataaa      960

ataaaggcaa ccaataaaaa aggacaggag acttattata ctgctgcaca gtttgtcata     1020

gcaacgggtg aaaggccacg gtatttagga atccaaggag ataaagaata ctgtattact     1080

agtgatgacc ttttttctct gccttattgc cctggcaaaa cattagtggt gggtgcctct     1140

tatgttgccc tggagtgtgc agggtttctg gctggctttg gcctagatgt cacagttatg     1200

gtacgctcaa tccttctccg tggcttcgac caagaaatgg cagaaaaagt gggttcctac     1260

atggagcagc atggtgtgaa gttcctacgg aaattcatac ctgtgatggt tcaacagttg     1320

gagaaaggtt cacctggaaa gctgaaagtg ttggctaaat ccactgaagg aacagaaaca     1380

attgaaggag tctataacac agttttgtta gctattggtc gtgactcctg tacaaggaaa     1440

ataggcttgg agaagattgg tgtcaaaatt aatgagaaga gtggaaaaat acctgtaaat     1500

gatgtggaac agaccaatgt gccatatgtc tatgctgttg gtgatatttt ggaggataag     1560

ccagagctca ctcctgtcgc catacagtca ggcaagctgc tagctcagag actttttggg     1620

gcctctttag aaaagatata tcatactttg ttctggcctc ttgaatggac agtagctggc     1680

agagagaaca acacttgtta tgcaaagata atctgcaata aattcgacca tgatcgggtg     1740

ataggatttc atattcttgg accaaacgcc ggtgaggtta cccaaggatt tgcagctgca     1800

atgaaatgtg ggctcacaaa acagctactt gatgacacca ttggaattca ccccacatgt     1860

ggggaggtgt tcacgacttt ggaaatcaca aagtcgtcag gactagacat cactcagaaa     1920

ggctgctgag gctaggcctg ctgctgttta gttctccttg tcatattctc atttctctca     1980

aagataagaa tgctctcgga taaaatgagc ctgtgctcat gacagctgct ctgttactca     2040

gggaccagtg cagggctgtc ttacgacact tagatgagaa agtagacaag gaaagaggac     2100

agcagtgggc atctgccttg tggtcttgct gacagcgaga agcagtggga ctgcttcctt     2160

gacgccttag cttggagccc cgttatgagg tgagccaagg ctgactctcg caagccagga     2220

ctgagcttcc ctcggaaaga cctttgagtg gcaccattca cctaagttag cttttctggt     2280

cgctattgtt tttatcccct ttgctttgtt gtttctgtga aaatatatt                 2329


<210> 4038
<211> 1554
<212> DNA
<213> Homo sapiens

<400> 4038
ctgcatccta ctgctatttt cattttatcg atggaatact ttgaagcacg aaaaatcatt       60

atatcttgaa ataattttta aaataatcca ataacaaact cagaactact gaagaataat      120

aaagaatatg ccgagtttct acattgcaaa ggaaagaaat ttacagattt tgatgaagtt      180

cgccttgaga ttgaagcaga aacagatcgc gtgactggaa tgaataaagg catttcctcc      240

atacccatta atttacgagt ctattcccca cacgtgttaa atctaaccct tattgatcta      300

cctggaataa ctaaagtgcc tgtgggagat cagccaccag atatcgagta tcagatcaga      360

gaaatgatta tgcagttcat cacgagggag aactgtctga ttttagctgt tactccagcc      420

aacactgatc ttgcaaactc agatgcgctg aagctagcta aagaagttga tcctcaaggt      480

ctgagaacca ttggagttat caccaaactg gaccttatgg atgaaggaac ggatgccagg      540

gatgttctag agaacaaact gttgcctctt cgcaggggtt acgtgggggt ggtaaacaga      600

agccagaagg acatagatgg gaagaaggac ataaaggcag ccatgctggc agagaggaag      660

tttttccttt cccacccggc ttacagacat atcgctgacc gaatgggaac cccacacctg      720

cagaaggtcc ttaatcagca acttaccaac cacattcggg ataccctacc aaacttcagg      780

aacaaactac agggacagtt gctctccata gaacatgaag tagaagccta caaaaatttc      840

aaaccagaag acccaacaag gaagaccaaa gcattgctgc agatggttca gcaatttgct      900

gtggactttg agaagagaat tgaagggtca ggggatcaag tagataccct ggaactctca      960

ggtggtgcta aaatcaatcg tatttttcat gaacgctttc cttttgagat agtaaagatg     1020

gagttcaatg agaaagaatt gcgaagagaa ataagctatg caatcaaaaa catacatggt     1080

atcaggacag ggttgtttac tccagacatg gcatttgaag cgatagtcaa gaaacagatt     1140

gtaaagttga aagggccttc cttgaagagt gtggatctgg taatacaaga attaatcaac     1200

actgtgaaga agtgtaccaa aaaactggca aacttcccca gactctgcga ggaaacggaa     1260

aggattgttg ctaaccacat tcgtgagcga gaagggaaga caaaggacca ggtattgcta     1320

ttgattgaca ttcaagtctc ttacatcaac accaaccatg aagacttcat tggcttcgca     1380

aatgctcagc agaggagcag tcaggttcac aagaaaacca cagttggaaa tcaggtgatt     1440

cgcaaggggt ggctcaccat cagcaacatt ggcatcatga aaggcggctc gaagggatac     1500

tggttcgtcc ttactgcgga aagcttgtcc tggtataaag atgatgagga aaaa           1554


<210> 4039
<211> 3107
<212> DNA
<213> Homo sapiens

<400> 4039
gtgcagaacc gtttggtttt cccgaggggt aggcagaatt tccaacccca cgagctgctc       60

cctctttccg caaacctcct aaccccgggg tttttccata aatgtgttta cttcgtccac      120

gccagcctgc gaagttccaa aatggagtct gggccacgcc ggcgttctgg gcacgactac      180

ggtctcttga aaagatttgg aattgaccat gtagataatc tctgagagca gttcttaaag      240

tgtaatccag aaccggtgga acttgctaga aacgcatatt cttcggaccc cctccaaatc      300

tgctgaatct gagattgtgg aggccattca atgtcccttc ttcaggaatt tggaaaaagg      360

atggagagat ctctctgagc tagactcttc agtggaggaa atgttacaac tcatggacag      420

tggcattacc atctgcctta ggaacggagc agcctctgtc ttcaagaaaa aagaatggag      480

cacacaagga gaagaaaaca agcaagacag taaactaaaa aagctgagtg aagacagttt      540

gactaagcag cctgaagaag tttttgatgt attagagaag cttggagaag ggtcttatgg      600

aagtgtattt aaagcaatac acaaggaatc cggtcaagtt gtcgcaatta aacaagtacc      660

tgttgaatca gatcttcagg aaataatcaa agaaatttcc ataatgcagc aatgtgacag      720

cccatatgtt gtaaagtact atggcagtta ttttaagaat acagacctct ggattgttat      780

ggagtactgt ggcgctggct ctgtctcaga cataattaga ttacgaaaca agacattaat      840

agaagatgaa attgcaacca ttcttaaatc tacattgaaa ggactagaat atttgcactt      900

tatgagaaaa atacacagag atataaaagc tggaaatatt ctcctcaata cagaaggaca      960

tgcaaaattg gcagattttg gagtggctgg tcagttaaca gatacaatgg caaaacgcaa     1020

tactgtaata ggaactccat tttggatggc tcctgaggtg attcaagaaa taggctataa     1080

ctgtgtggcc gacatctggt cccttggcat tacttctata gaaatggctg aaggaaaacc     1140

tccttatgct gatatacatc caatgagggc tatttttatg attcccacaa atccaccacc     1200

aacattcaga aagccagaac tttggtccga tgatttcacc gattttgtta aaaagtgttt     1260

ggtgaagaat cctgagcaga gagctactgc aacacaactt ttacagcatc cttttatcaa     1320

gaatgccaaa cctgtatcaa tattaagaga cctgatcaca gaagctatgg agatcaaagc     1380

taaaagacat gaggaacagc aacgagaatt ggaagaggaa gaagaaaatt cggatgaaga     1440

tgagctggat tcccacacca tggtgaagac tagtgtggag agtgtgggca ccatgcgggc     1500

cacaagcacg atgagtgaag gggcccagac catgattgaa cataatagca cgatgttgga     1560

atccgacttg gggaccatgg tgataaacag tgaggatgag gaagaagaag atggaactat     1620

gaaaagaaat gcaacctcac cacaagtaca aagaccatct ttcatggact actttgataa     1680

gcaagacttc aagaataaga gtcacgaaaa ctgtaatcag aacatgcatg aacccttccc     1740

tatgtccaaa aacgtttttc ctgataactg gaaagttcct caagatggag actttgactt     1800

tttgaaaaat ctaagtttag aagaactaca gatgcggtta aaagcactgg accccatgat     1860

ggaacgggag atagaagaac ttcgtcagag atacactgcg aaaagacagc ccattctgga     1920

tgcgatggat gcaaagaaaa gaaggcagca aaacttttga gtctaatttc ctctctgttt     1980

ttaactattc tggagaccaa gaaaccacta ggaattgaag gaatatttgg atatttttaa     2040

tcctaagatt ttgccctaca attaggcaga ggtcaaaaag tgacaatggt acatgcccag     2100

gtaaattccc aaaaggcaga attgacagtt gtatctgctg tgcattcact ctaagatgag     2160

gagaacaaaa gaagtgtatt ctcttgttct gtcagctgca taccagtaat aaaactgtta     2220

tgaaatggat tttcaaggtc tctaaacctt gaaaatccaa agctattgtt gcattgtaca     2280

gcactgaagg gctttatgtt acaatattct ttattcctat ctagtatact aggctattta     2340

ttgtatcccc ttaggtaaac ttatttattt atgctatttt gctttgtttc attttttaag     2400

gacaagatca ggatagcttt ggtgaaggta gggtcatatt aatatgatga taatgtgcaa     2460

ccaatttata ctttctgcag ggagctatgg ggtacattcc ttgatttcca ggatagtttt     2520

tcaaatagga aagcaataat ggcagtagtt ctcaaatggg ctaggccttt tttatattga     2580

agcaataatt ccatttttac cctttgaaat tttgtttttt tgatttttga tgtttggtac     2640

aaatagaact atatatattt aggtaaaata gatctatcgt gtttaaaacc aaagaaatca     2700

atggaaccct tgcacaaaaa agtgtgataa atatttttaa ataaaaactt aatacaaatg     2760

taatttgtta atattgtttc atgttttatg tgtagatcta atagctgaac tgattcaaac     2820

tgtaataagc tcatcaattt catttctatg aaaatgtgct ctgttgtcac aggatgtttc     2880

tgttgatttt attcatttcc tgggaattgg taaacatcat gttcctgatg ataacccagt     2940

agcaaaaaca tttgtactga gtggtacaag ccttggggac tgaaaaaaaa aagattaaaa     3000

ccattaaaaa gaaactcatt tttacgctga atgaacattt atatgattgc attgggacca     3060

gtcatttcct aagctacata tggccatctt gacagtgttt tttcttt                   3107


<210> 4040
<211> 2522
<212> DNA
<213> Homo sapiens

<400> 4040
agagcgtctg cttgaaaatg gatcctcact tcttcacttg gatataataa tatagactgc       60

cgacattctg ggaactgatc agtcttccag cttccagtgt ggtgccctcc ctcaattgtg      120

ctgagtgtcc cccaatccag agatattctg taatttcttc ctcagaaaga aacaaaacaa      180

aattctgatc ttcccagatg aagataatgg attctgaatt aatgcatagt atagtaggaa      240

gctatcataa acctccagaa agagtatttg ttccctcatt cacccagaat gaaccatctc      300

agaattgcca tcctgcaaac ttagaagtta cctctcctaa gatacttcat agcccaaata      360

gccaagctct tattttagcc ttaaaaactc ttcaggaaaa aattcatcgt ttagagctgg      420

agagaacaca agctgaagat aacctgaaca ttctttccag agaagcagca cagtataaga      480

aggccttaga gaatgaaaca aatgagagaa atctggcaca ccaggagctg ataaagcaga      540

aaaaagatat aagtatacag ttaagctcag cccagtctcg ttgtactctt ctagagaagc      600

aactagaata tacaaagaga atggttctca acgtagagcg agaaaagaac atgatcctag      660

aacaacaggc ccagcttcag agggaaaaag aacaagatca gatgaagctg tatgcaaaac      720

ttgaaaagct tgatgtctta gaaaaagagt gtttcagact tacaacaact cagaaaactg      780

ctgaggacaa gattaaacat ttagaagaaa aacttaagga agaagaacat cagcgtaagc      840

tatttcaaga caaagcttct gagcttcaaa ctggacttga aatcagtaaa attataatgt      900

cttcagtttc aaatctaaag cactccaagg aaaagaagaa atcttcaaag aaaactaaat      960

gtataaagag acgaccacct tggcaaattt gttcaaagtt tggagcactg ccttttgtgg     1020

ctgaaaagat gaggcaacat cgtgacccac atatccttca gaaacctttt aacgtgactg     1080

agactagatg tctccccaag ccttctagaa caacttcctg gtgtaaagct attcctcctg     1140

actcagaaaa gtccatttcc atttgtgaca atttatctga acttttgatg gcaatgcaag     1200

atgagctgga ccaaatgagc atggagcacc aagaactact gaaacaaatg aaggaaactg     1260

aaagtcattc agtctgtgac gacatagaat gtgaactaga gtgtttactc aagaaaatgg     1320

aaattaaagg agaacaaatc tccaaactga agaagcatca agacagtgtc tgtaaactgc     1380

agcaaaaagt tcaaaactca aagatgagtg aagcttcagg tattcagcaa gaagacagct     1440

accctaaagg atcaaagaac ataaaaaata gccccagaaa atgtttgact gacactaacc     1500

tttttcagaa aaacagcagc tttcatccaa tacgagttca taatcttcaa atgaaattga     1560

gaagagatga tatcatgtgg gaacagtaac aaaacagcaa aactgtcacc ttaatgaact     1620

ttgtcagtga gaccttgaat tgtctaaagt ggttttaatt taatataact ttgtgacatt     1680

ttgaatcatg tttctagttt ctataaaaca tgaagttgca gtatttaaaa attaatgcct     1740

aatgacctgg tgggttccaa ataataaatt aattgctttt ttatttttct tattgattga     1800

agcccgtaac ctcatcttgt cttagaaaca ttgttggctt tgcagatatc ttaagctaaa     1860

tttaagaaat tgtactagat tgacaatatt caaaattgag ttaaatccaa gctacaagta     1920

ccattcattc cacttttcat ttagtaggtt tggaacctta aaaaccaatg ttcaatgaac     1980

agagttcaga aagatcattt agctttcctg gtgccttctt tctattttgt tttagagctg     2040

tgaaatgttt ttctcttttg gaaaaggaaa aacttaatag ttacacagtt ttgtgaagaa     2100

gcctttaatc caagttttat gagacagtag gaacctatag ctacttaatt tttaggagac     2160

agtaattcag ttgcagaagc tttcctctgc tattcccatt ctcttttaca aaactagttt     2220

tttttaaaaa atcaatgatc aattttatct tactacttta taacttttgc tgacttttat     2280

tctttgcatt gtatgtaatg tccatcagta taaattgaga ctgtgaattt ctaggaccca     2340

caaaagtggt attttttttt tgtacaagaa agtatagagg aagaggaagc tgggcattaa     2400

attacctcat ccagcagaaa ttcacggtag tatggtatat ttttattttt tatattttaa     2460

aatcaataat gtcaaatgtc attgtgtatg catgctttat aataaattta cacttgatca     2520

tt                                                                    2522


<210> 4041
<211> 5033
<212> DNA
<213> Homo sapiens

<400> 4041
ttgttctttc ctggccttgt ggagtttcac gttttttatt cagttaaaga ttcaaggtac       60

tcctaagcag atttctgaag ctctttttcc atgtaattcc ctcctctcca gaattctgcc      120

ctacaaattc caaccgactt ggcctacccc aatttcgtca actccaatct ctgtcttttc      180

aacccaggag atcctaggtt tccatatgat ttcctttcat cgcaccacag actggaaatc      240

gcctctgggc aaaagggcag gatgatatac ggctcctttt atttcttttc tctcaggaaa      300

cactgacggg aacacacgtg ccggtgctac cctccagtga ctggactaga tccttgcgca      360

acttcaaccc gcgctagctc cgcctacggc cggccacgcc ccgtcttctc accggcgcgc      420

ctccctcttg ttcgtcctcc ctccccctgt ggactgcggc gctggcgttc cgcgcacgcc      480

ggctcactgc gcctgcccgg cgtgtggacg ccacacgctc ccggaagtgg gaggtggccg      540

ctggagtttg tgtggccgcc gccgcgggaa cgcgagcccg gtaatttttc aacggagaaa      600

ggcgaggctt tcgggctctg cagagtgaga gttagcaagt gtccggctcc agcaactctc      660

ctctggcgtg acagccggca tggaggatcc acagagtaaa gagcctgccg gcgaggccgt      720

ggctctcgcg ctgctggagt cgccgcggcc ggagggcggg gaggagccgc cgcgtcccag      780

tcccgaggaa actcaacagt gtaaatttga tggccaggag acaaaaggat ccaagttcat      840

tacctccagt gcgagtgact tcagtgaccc ggtttacaaa gagattgcca ttacgaatgg      900

ctgtattaat agaatgagta aggaagaact cagagctaag ctttcagaat tcaagcttga      960

aactagagga gtaaaggatg ttctaaagaa gagactgaaa aactattata agaagcagaa     1020

gctgatgctg aaagagagca attttgctga cagttattat gactacattt gtattattga     1080

ctttgaagcc acttgtgaag aaggaaaccc acctgagttt gtacatgaaa taattgaatt     1140

tccggttgtt ttactgaata cgcatacttt agaaatagaa gacacgtttc agcagtatgt     1200

aagaccagag attaacacac agctgtctga tttctgcatc agtctaactg gaattactca     1260

ggatcaggta gacagagctg ataccttccc tcaggtacta aaaaaagtaa ttgactggat     1320

gaaattgaag gaattaggaa caaagtataa atactcactt ttaacagatg gttcttggga     1380

tatgagtaag ttcttgaaca ttcagtgtca actcagcagg ctcaaatacc ctccttttgc     1440

gaaaaagtgg atcaatattc ggaagtcata tggaaatttt tacaaggttc ctagaagcca     1500

aaccaaactg acaataatgc ttgaaaaatt aggaatggat tatgatgggc ggcctcactg     1560

tggtcttgat gactctaaga atatcgcccg aatagcagtt cgaatgcttc aggatgggtg     1620

tgaactccga atcaacgaga aaatgcatgc aggacagcta atgagtgtgt cctcttcctt     1680

accaatagag ggcactccac caccacaaat gccacatttt agaaagtaac aacagttttg     1740

tgtgtggatc attccaattg aagttgctat gaagaggtag cagatgaatc tcattgaatt     1800

agtcctgtag tgcaaacttt aagcacctta aaacatttaa aatcttatta caggtgatag     1860

agatagatac atgtatgtga acagattttg taggaaggca tactgaattc tttgtcacca     1920

gcacttttga tatgaacagt attcgttaca tagtaacagt tcctgcttac aactgaattt     1980

tataatttaa ggtgttcaag atatattctt tttggtttta aaatgcaaaa tcttattggc     2040

tgttctgttg aatgtcatat cttactggtg tttaaatatg taatgtgttt ctttattaac     2100

atcactagat gaaaccatat cttaaaatgc agaaatgatt ggaaggtaga tcttatctag     2160

cctttggatt tcaagaatat catagtcctt ttgattttca aagtttatat gtgaagttca     2220

ccatgtatgt ggtgaatttc gtaaggtact tggtatacat atctgcctat gtttcttttc     2280

aactcataat tggaagaatt atgatggatt atagggtttg gttaaaaatc cagttactga     2340

aggaattaat gaaaacgtag aagaaagtac taaaaggaat atcataaggg ctgtagctca     2400

aacttcataa tacataaatc actggggtct ttttggattt ggttgtttga ttcgccttcc     2460

ttttttgaca tatgtatgcc ttaattctta aatctgaggg accatgcttt gaaatagact     2520

gaaaattaag ggtcaccacc taattttact ttgtattcag tatcgtaagt gaggttaata     2580

aagtcaatac tttctaccat atattacgtt tttgttatta aaaaacttca ttggccacta     2640

gtgaagttag tcaataaaag acttgttttt ctgattttac atagtaaatg gctgctaagt     2700

attgagtaat tcttaactaa ttctaaaaac taaaatgtgc atttcgactt gataaggtaa     2760

aactcttatc tagaggctaa acccatgtat tttcagaatt gaatttttct ccttgtagct     2820

ttcagggaac aatttcattg acattgcttg cttcctgcct tttacctttt aataaaaatt     2880

gtgatgctac tttattctaa agatttatat tttataacca gatgaatttc ctcaaaggtt     2940

tccaaaccta tatcatatag ggtgaaaagc aggaaagtag acatttttct tggcgtggga     3000

attctctaca tagggcagta gatttcttaa gccaatgaat ttctgctttt cagcagtagt     3060

catataatca gtatcataaa gaataatgtg taaataacag aaggcatatg agagtgtggt     3120

gttcctagat gaactgttac agattatagt aaaataagga aatctaagtg ctttaagttt     3180

atacagttaa ctcttaggat aagagggatg tatgctgaga tgtttgtgca tcccagatag     3240

cactgtacaa taacctgtaa agtattactg aatactgaat agctgaaact gcaattggaa     3300

aatctgatga tgacgaggaa atattacgtt tccagttttt ttagctctat ctgctaattt     3360

ctttgcctgt tttcactttc gccaagtacc aacaagctca tgttgtattt ctttttaaga     3420

acttcaacat tataagctct cagtacccta ttttgttgtt gttgttgttt gagacagagt     3480

ttttgctcgt ctgccaggat ggagtgcagt ggtgcgatct tggctcactg caacctccgc     3540

ctcctgggct caggtgatcc tcttgcctca gcctcctgag tagctcagat tacaggcgcg     3600

tgccaccaca cccgcctaat ttttgtattt ttggtagagg cggggtttca ccatgttggt     3660

caggctggtc ttgaactcct gacctcaagt gatttgccca ccttgacctc ctacagacgt     3720

gagccactgc gctcagccat agattttact gtcttaaccc attttaattc ctctgttgag     3780

tctctgtcct cccctccaat ttgatttggg attttgctga tgagatgata ctaaacattg     3840

agagtactgc tttttactct gacttttatt gtgttgtctt tgaaagacaa atagtacaac     3900

tttttacaag gaaacacgta agagatggat gtccatgaaa acaatattag tatattctat     3960

tattgtttct tattaatagt tacttagtat ttacaaacaa tttattatta gctgtgttaa     4020

cttttattct atgcttcata tgctctgaca ttgacatagt ggatttctgc tgattttttt     4080

caaatccgca atctttataa ccaactgaag tatataatag agcattacat tttatcttta     4140

tttgtgttct gttggatcaa gtatttaaca tttgctctga aaaaaatgtt tttgtgatgt     4200

gtctttgttg ccttgagata gatccattta tcctgcctcc tagggagaag tttctgcctg     4260

gattgaaaca aaaaaacaca ggcgtcacaa gcatgttacc tattaagaga gagagggtat     4320

ctctgaagac taattaaaat ggtaattttt aaaaagatgt gaccagttga cttttagtat     4380

atcatcccaa gtattatccc caaaatgata atgcaaaaca gaataatttg gagaccagga     4440

gaaaaactgg tatgattact ggggagggga agaagcacag gtggtcaaga taataatgca     4500

tgtttggcct cagctgtagt tgccaaagaa actacctgcc tcacagatga gcacgcacgg     4560

gtgcattgtc aaagtctgag aaggatgtat tgtactttga aggaagactt tccatttcta     4620

agctaccatg gagaagtata tgctcctcga gaccagagac tgtgacttct gcatctttga     4680

ttccagcgac atatgataaa atgttttgca catagttgaa tccagcgttg atacatgaag     4740

gacagcatta catctttttt ctattatact tagaaatttc ctctttgttc tgcaccacca     4800

acctgtatat caagcctcct tgccccacaa agcttccaaa gcccgtaaat ttgttaatct     4860

agagcagggg tcagcaaact accacccatg ggccaaatct ggctgctgcc tatttttgta     4920

tggcctacaa actatggttt ttatattccc ttttgttaat ggctcaaaat aatattttgt     4980

ataatacgaa aattacgaaa ttttagtttc tctaaataaa gttttggaaa gaa            5033


<210> 4042
<211> 1373
<212> DNA
<213> Homo sapiens

<400> 4042
gctgctgggg ctcggcgggg ccgtgtctgg tctgcaaggc gcgcgggctc gtggggggtt       60

ggctggggag cccacgctgc ctggcgactc gggccaccga atgtgagacc gagtcccttt      120

atgtcaccag cgcacacgct gatttgaacc ctgcttcgac gtgtgtgtca tggcttaaaa      180

atagctgcta atctgtcaac ctgtcttggg cagaaacagc ggcggcgaca gcagcaggag      240

cgtcatggcc gtggcgctgt ctgcgccggc gatccgcctt tcggactgag gcccagcgca      300

gcgcttgcaa agagagccaa agagctgagc aaaaggagct gctgcagctt gaagaaaaag      360

ccacccctga aggctcctgc cagagccagg cttaccttct ctccctcgag aatcttctcc      420

cgaaggacca gcccagggaa gggaagcagc tgctctggac tcactcaagt gtgtctcaca      480

ccccttcctc ttccagcagc agctacctgg caactgaacc catcatcacc acagccactc      540

ctgcagctgc cacggtttct gccacctcta agatgtgccc tggtaactgg ctttgggctt      600

ctatgacttt tatggcccgc ttctcccgga gtagctcaag gtctcctgtt cgaactcgag      660

ggaccctgga ggagatgcca accgttcaac atcctttcct caatgtcttc gagttggagc      720

ggctcctcta cacaggcaag acagcctgta accatgccga cgaggtctgg ccaggcctct      780

atctcggaga ccaggacatg gctaacaacc gccgggagct tcgccgcctg ggcatcacgc      840

acgtcctcaa tgcctcacac agccggtggc gaggcacgcc cgaggcctat gaggggctgg      900

gcatccgcta cctgggtgtt gaggcccacg actcgccagc ctttgacatg agcatccact      960

tccagacggc tgccgacttc atccaccggg cgctgagcca gccaggaggg aagatcctgg     1020

tgcattgtgc tgtgggcgtg agccgatccg ccaccctggt actggcctac ctcatgctgt     1080

accaccacct taccctcgtg gaggccatca agaaagtcaa agaccaccga ggcatcatcc     1140

ccaaccgggg cttcctgagg cagctcctgg ccctggaccg caggctgcgg cagggtctgg     1200

aagcatgagg ggagggggag agaggtcagg ccaggcccgt gggtaggtcc ctggctccca     1260

gctggagata ggaggcccag gtggcaggta gcaggaggcc cagatcaccc atcctcccct     1320

ggggtcagga gaggccgagc cccaggccac tgtcactctt tgtgggaggg gac            1373


<210> 4043
<211> 1491
<212> DNA
<213> Homo sapiens

<400> 4043
ctctcccccc gggctccgcc caccccacgc cgggaaccca cgcgggccac tacaagcccg       60

ccctttccta cgtctggtcc agtcggtctt cctccggccc gggccctggc ccagctagcc      120

ggccatggaa gtgaagaaaa tatttggaag ctctgtgaat acatcaaaaa ccatgaccag      180

tatcctttag aagaatgtta tgctgtcttc atatctaatg agaggaagat gatacctatc      240

tggaaacaac aggcgagacc tggagatgga cctgtgatct gggattacca tgttgttttg      300

cttcatgttt caagtggagg acagaacttc atttatgatc tcgatactgt cttgccattt      360

ccctgcctct ttgacactta tgtagaagat gcctttaagt ctgatgatga cattcaccca      420

cagtttagga ggaaatttag agtgatccgt gcagattcat atttgaagaa ctttgcttct      480

gaccgatctc acatgaaaga ctccagtggg aattggagag agcctccgcc gccatatccc      540

tgcattgaga ctggagattc caaaatgaac ctgaacgatt tcatcagtat ggatcccaag      600

gtaggatggg gcgccgtcta cacactatcc gaatttacac atcggtttgg cagtaaaaac      660

tgctgaactt ggtctcaaga tgtggaactg tggagaaatt ctaggacatg aacaagctat      720

cctttcatcg aggacagcaa acattatggt acagttggct tggaattatg tctttctctt      780

ttaatttgat tgagtggaaa tctgagtgaa tacaaatata aatgaacaac ataaaaactt      840

ttgttttgac atgtcaaatt gaaacttgat aaagtgcgta cttgctaaga tattcctgtg      900

gctcatgcgt tacaacacga ggacttaagc cagtaatcgt ttttgttcag atagaggtgt      960

ggaggtagag ccagcccctc atgtctgttt tggatgtttt gtgtctctcc agctacattg     1020

taagttcctt gagggcaggg ccatggccca ttgctctgtg aatctcaaat gcccataaaa     1080

ggtgcccata aaatgttttc ttgaacattt gaatgtgctg ttgtctggaa aggggtaata     1140

ttgtgagctg aatcagcaat aagtattagt ctttttggac tatggtattg ttaaaaagac     1200

tgcagccctc tcagacttga gcgttaattg gcttatttat ttatggcttt aaataaaatc     1260

gatttaacgt tagttttgtt ttgaagattt ttgtgtcacc cttgatgatc tgaaatacct     1320

aaatatgcct caattgtaga tgagaaccag ggctttaaaa aatatttatt acatgtgcct     1380

tctggaagac atcttggtta tttggcttta atcatatcat tccaaatgaa agatatttgg     1440

cattacattg gcatatagta ccagctctca tgttttcatg attctacttt a              1491


<210> 4044
<211> 575
<212> DNA
<213> Homo sapiens

<400> 4044
agtgtcaggc tctgggagag aggaagtgat cgctcccgga ggagcgcgag ccgagcggcc       60

ggcgcagcgt gagacagcac atcctgcccg cgccggcccc gccaccttcg ggagccgcct      120

gcaccaacgc tgccgccgcc caggagccgc cgccggctcg gggagcccag ttccgccgct      180

gccgagcgcg tccagtctca ctctgccacc caggctagag tgcagtgcat gattataact      240

cattgtaacc gtgaattctt ggcgtcaagc tgtcctcccg cctcagcctc ccaaagcact      300

ggggttacag gaaaccaaca tgtctgacaa aagtgactta aaagctgagc tagagcgcaa      360

aaagcagcgc ttagcacaga taagagaaga gaagaaacgg aaggaagagg agaggaaaaa      420

gaaagaggct gatatgcagc agaagaaaga acccgttcag gacgactctg atctggatcg      480

caaacgacga gagacagagg ctttgctgca aagcattggt atctcaccgg agccgcctct      540

agtcccaacc cctatgtctc cctcctcgaa atcag                                 575


<210> 4045
<211> 819
<212> DNA
<213> Homo sapiens

<400> 4045
ggggccaccg cgacgttgcc tgtgggtgcc cgcgaaccaa cggttagcgg tggcaggggc       60

tgactgagag cgtctgcttg tgcctggtac ctagtacaaa cttaataaat gtgtgacgca      120

agaataaagg aatgaatgaa tggaagaatg atataatgcc acagaacttt caaagatggg      180

actgtctagt tgcaaaaaca agctcaggga tcccactgat tctactttac gataatggat      240

tctgaattaa tgcatagtat agtaggaagc tatcataaac ctccagaaag agtatttgtt      300

ccctcattca cccagaatga accatctcag aattgccatc ctgcaaactt agaagttacc      360

tctcctaaga tacttcatag cccaaatagc caagctctta ttttagcctt aaaaactctt      420

caggaaaaaa ttcatcgttt agagctggag agaacacaag ctgaagataa cctgaacatt      480

ctttccagag aagcagcaca gtataagaag gccttagaga atgaaacaaa tgagagaaat      540

ctggcacacc aggagctgat aaagcagaaa aaagatataa gtatacagtt aagctcagcc      600

cagtctcgtt gtactcttct agagaagcaa ctagaatata caaagagaat ggttctcaac      660

gtagagcgag aaaagaacat gatcctagaa caacaggccc agcttcagag ggaaaaagaa      720

caagatcaga tgaagctgta tgcaaaactt gaaaagcttg atgtcttaga aaaagagtgt      780

ttcagactta caacaactca gaaaactgct gaggacaag                             819


<210> 4046
<211> 1966
<212> DNA
<213> Homo sapiens

<400> 4046
ctgcctccga ctccccactg gactgcatgg cgacggcgtg tggtggggca gtcagctaag       60

ccatttgcct aaggggctgt cgggcatctg cgtgctgggg accgacagtg tgggtgtgtt      120

aggaggatct gtatggagca cattgctgcc tctggctagg acagggtgga aagggtggcg      180

tggctacagc ctgacccatg ggcaccgtcc taccctttgt tctgtgcttc cgagtgtcag      240

tcatgtgctg gggtctgtgg gcccatgact cagacggtga gctctgacct tcctgagcca      300

gggctttgct gtagttgtgc ctggctcagg agctctagga caaggggacc gctccaggtc      360

tgcatctacg gtgtggcagg gcccctcggc actcttgtgc actagtgtca tctttcccat      420

tgaaatgact gtgaggacca gaatgtgcac atgcagatgg gcagctactt gtctgccttg      480

gccctttatt acacaacttg ctgggggtgg agatgccacc ccccggcagt cagagcccct      540

ttatgatgtc atggggctgg ttacatgact gccaaggggt gctgctggcc acactgcact      600

agcaagtttg ccagatggag gacaagcgat cattgagtat ggctcgctgt gaagaaagaa      660

attcgagagg acaggatcat ggcttggaaa gggtgccttt ccctccccag ttgcagtcag      720

agacctacct tcacccagca gatccttccc ctgcctggga cgacccgggg tccactggga      780

gccctaactt gaggctgctg acagaagaaa tcgctttcca acctctggcc gaggaagctt      840

cgttcagaag gccgcaccct gacggtgacg tcccgcccca gggagaagat aatctcctct      900

ccctcccctt tccacagaaa ctgtggagac tggtcagcag caaccagttt tcgtccatct      960

ggtgggatga cagtggggct tgtagagtga tcaatcaaaa actctttgaa aaggagattc     1020

tcaaaaggga cgtcgcacac aaagtgtttg ccacaacttc gataaagagc ttcttccgcc     1080

agctaaactt gtatggcttc cgaaaacggc gtcaatgcac tttcaggacc ttcacccgca     1140

ttttctccgc aaaaaggctg gtctccatct tgaataagtt agagttctac tgccatcctt     1200

actttcaaag agactcccct cacctcctcg tgaggatgaa gagaagagtg ggtgtcaagt     1260

ctgcaccaag acatcaggag gaggacaagc cagaagctgc tggatcctgt ctggcaccag     1320

cagacactga gcaacaagat cacacgtctc cgaatgagaa tgaccaggtc acaccgcaac     1380

accgggaacc ggccggtccc aacacccaaa tcaggagtgg ctctgctcca ccagcaactc     1440

ctgtgatggt gcctgattcc gccgtggcga gtgacaacag tccagtgacc cagccggccg     1500

gcgagtggtc agagggcagc caggctcacg tcactccggt ggccgctgtc cctgggcctg     1560

cagcgctgcc cttcctctat gtccctggat ctcccactca gatgaattct tacgggcctg     1620

tggtggccct tcccacagcg tcccgtagta cccttgccat ggacaccaca ggacttcctg     1680

cacctggcat gctgcccttt tgccatctct gggtaccggt gaccctagtg gctgctgggg     1740

ctgcacagcc tgctgcctcc atggtcatgt tcccccatct cccagctctg caccaccatt     1800

gcccccacag ccaccgcacg tcacagtaca tgccagctag cgatgggccc caggcgtacc     1860

cagactacgc agaccagagc acatagaggg cagcatttgg gcagaatatg tgctggtcaa     1920

taaatgtgtc agaaaatgag taattttctg actgcacaaa aaagtc                    1966


<210> 4047
<211> 2950
<212> DNA
<213> Homo sapiens

<400> 4047
ggtgttgggg ggcggggcga gcggctgcct cgcggattcg cgcgggtggt gagagtggcc       60

agcgagggca gcgttcgccg cccctcaggc cccgtcccgg cgccgcagcc gcctgcgttt      120

cggtttgtga gcaggcccgg ccgggccagg agcgagagcg agactctgga gcggtcgccg      180

ccgcagtcgc ccgggccggg aaaggcgggc gatgccccca accgccgctc gggccatgtc      240

cgaggggcgc gcgtgttgtc gccgccgggg cgccgtgccc gcctgtcgtc ccccgggccc      300

agccgctcgt ccgaggcccg cgaggagctg cgccgccacc tcgtgggcct catcgagcgc      360

agccgggtgg tgatcttcag caagagctac tgtccccata gtactcgggt gaaagaactc      420

ttttcttctt tgggagtcga atgtaatgtc ttggaacttg atcaagttga tgatggggcc      480

agggttcaag aagtgctgtc agaaatcact aatcagaaaa ctgtgcccaa tattttcgtg      540

aataaagtgc atgtaggtgg atgtgaccaa actttccagg catatcagag tggtttgtta      600

cagaagctcc ttcaggaaga tttggcatat gattatgatc tcatcatcat cggtggtggt      660

tctggaggcc tttcatgtgc gaaggaagct gccattttgg gaaagaaagt tatggtgcta      720

gactttgttg tcccgtcacc tcagggcaca tcctggggtc ttggtggcac ttgtgtaaat      780

gtaggttgta ttcctaagaa attgatgcat caggctgccc ttttggggca ggcattatgt      840

gactcaagga aatttggctg ggaatataat caacaagtga ggcacaactg ggagacaatg      900

acaaaagcga ttcagaacca catcagctct ctaaactggg gctacaggtt gtctctgagg      960

gaaaaggctg tggcctatgt caattcctat ggagaatttg ttgaacatca taaaataaag     1020

gcaaccaata aaaaaggaca ggagacttat tatactgctg cacagtttgt catagcaacg     1080

ggtgaaaggc cacggtattt aggaatccaa ggagataaag aatactgtat tactagtgat     1140

gacctttttt ctctgcctta ttgccctggc aaaacattag tggtgggtgc ctcttatgtt     1200

gccctggagt gtgcagggtt tctggctggc tttggcctag atgtcacagt tatggtacgc     1260

tcaatccttc tccgtggctt cgaccaagaa atggcagaaa aagtgggttc ctacatggag     1320

cagcatggtg tgaagttcct acggaaattc atacctgtga tggttcaaca gttggagaaa     1380

ggttcacctg gaaagctgaa agtgttggct aaatccactg aaggaacaga aacaattgaa     1440

ggagtctata acacagtttt gttagctatt ggtcgtgact cctgtacaag gaaaataggc     1500

ttggagaaga ttggtgtcaa aattaatgag aagagtggaa aaatacctgt aaatgatgtg     1560

gaacagacca atgtgccata tgtctatgct gttggtgata ttttggagga taagccagag     1620

ctcactcctg tcgccataca gtcaggcaag ctgctagctc agagactttt tggggcctct     1680

ttagaaaagt gtgattatat taatgttccg actacagtgt ttactcctct ggagtatggt     1740

tgctgtggat tatctgaaga gaaagctatt gaagtatata aaaaagagaa tctagaaata     1800

tatcatactt tgttctggcc tcttgaatgg acagtagctg gcagagagaa caacacttgt     1860

tatgcaaaga taatctgcaa taaattcgac catgatcggg tgataggatt tcatattctt     1920

ggaccaaacg ccggtgaggt tacccaagga tttgcagctg caatgaaatg tgggctcaca     1980

aaacagctac ttgatgacac cattggaatt caccccacat gtggggaggt gttcacgact     2040

ttggaaatca caaagtcgtc aggactagac atcactcaga aaggctgctg aggctaggcc     2100

tgctgctgtt tagttctcct tgtcatattc tcatttctct caaagataag aatgctctcg     2160

gataaaatga gcctgtgctc atgacagctg ctctgttact cagggaccag tgcagggctg     2220

tcttacgaca cttagatgag aaagtagaca aggaaagagg acagcagtgg gcatctgcct     2280

tgtggtcttg ctgacagcga gaagcagtgg gactgcttcc ttgacgcctt agcttggagc     2340

cccgttatga ggtgagccaa ggctgactct cgcaagccag gactgagctt ccctcggaaa     2400

gacctttgag tggcaccatt cacctaagtt agcttttctg gtcgctattg tttttatccc     2460

ctttgctttg ttgtttctgt gaaaatatat tttcagttaa gaaatgctat aaagtagtgg     2520

ttttctagtg cgtgggccta gaattcacac atgctcactg gtgaacagtg tctgtgggct     2580

gctgtgggct gcatttggat agctgtctgc attagcagga agctgtacac actgtgtagg     2640

gttagtcatc tcttttcttt tttgaggcac atttaaccta ctgtcaaaac gctgactcat     2700

gcttcaccct cacactcact acttggtggt gataaccttg aagctattct cccctaatta     2760

atatctcgag actgagcaaa atatctcatg taagataaaa gtacttgaat tgctttttca     2820

tgttcatctt aatagtatta tttccaaaag tttttaatac tgtattatgt gaaatctaac     2880

taatttatct gtgaaataat tccatcacag tctgtttaat gatgataaag ttccataaat     2940

gaatacaggt                                                            2950


<210> 4048
<211> 949
<212> DNA
<213> Homo sapiens

<400> 4048
ggccgttgtt ggtcgagctg gcgggtcccg cgggccaggc cgtggaggct ttggtgtcag       60

gatgatgctg gcttcataaa atgagttacg gaggattcct tctttttata ttgattggaa      120

tagtttcaga aggaatggta ccagctcctc tttgtacctc tggtagaatt cggctgtgaa      180

tccgtctggt cctggacttt ttttgagctc ctgaaggaag cactaaacat ggaaaggaac      240

aaccggtacc agccactgca aaaacatgcc aaattgtaaa gaccatcgat gttaggaaga      300

aactgcctca actaatgagc aaaataacca gctaacatcg taatgacagg atcaaattca      360

cacataacga tattaacctt aaaggtgtta cctcattttg aaagtcttgg gaaacaggaa      420

aaaattccta acaaaatgtc agcttttcga aatcattgtc cacatttgga ttcagttggt      480

gaaataacaa aagaagattt gatacaaaaa tcccttggta cttgtcagga ttgtaaagtc      540

caaggaccaa atctttgggc atgtctggag aatagatgtt catatgttgg ctgtggtgaa      600

tcacaagtag atcacagcac catacattct caggagacaa agcattatct aactgtgaac      660

cttaccactc ttcgagtatg gtgttatgct tgcagcaaag aagtattttt ggataggaaa      720

ttaggaactc agccttcatt gcctcatgta agacaacctc accaaataca agaaaacagt      780

gtccaggatt ttaaaatacc cagtaataca acattaaaaa ctcctctggt tgccgtattt      840

gatgatctgg atatagaagc ggatgaagaa gatgaactta gggccagagg tcttacaggt      900

ttgaaaaata ttggaaatac ttgttacatg aatgcagctt tgcaggctc                  949


<210> 4049
<211> 4014
<212> DNA
<213> Homo sapiens

<400> 4049
caaacactaa cgatggcggc gccgggaagc gaccggctgc tgggcttaag gcgggagtga       60

ccgcttaacc agtgagggaa gcactgaaga gcgccagtcg acgtgggtgc gacaactcgc      120

ggagtcttag gagcaaaacg tctggggcct gcgagccagg acccttctga agccttaggt      180

gtctatcggc gacgtgtacg gtcactgcag ctccggagcg cggaaccctc agccaggagg      240

cgcggctggt cggtcccagg tcccggcctc cgtaatgaga gcccggaacc actctttgtg      300

ccgcagcttc gcagcatctt ggactcaagt gattctcctg cctcagcctc ctgagtagct      360

gggactacag attcctatag gcaatggaaa ctgatctcaa ttcccaggac agaaaggacc      420

tggacaagtt tattaaattt tttgccctca agactgtcca agtgattgtc caggctcggc      480

ttggtgaaaa gatttgcact cgttcatcat cttctccaac gggttcagat tggttcaact      540

tagcaatcaa agacatccca gaggttacac atgaagcaaa gaaggcactg gcaggacagc      600

tgcctgcagt cgggaggtcc atgtgtgtgg agatttcact taagacttct gagggagatt      660

ccatggagct ggaaatatgg tgtcttgaaa tgaatgaaaa gtgtgataaa gaaatcaaag      720

tttcctacac ggtgtacaac agactgtcat tgctgctgaa gtcccttctt gctataacta      780

gggtgacacc agcctatagg ctctccagga aacaagggca tgaatatgtc atattataca      840

ggatatattt tggagaagtt cagctgagtg gcttaggaga aggcttccag acagttcgtg      900

ttgggacagt gggcacccct gtgggcacca tcactctttc ttgtgcttac agaattaact      960

tggcattcat gtctaccagg caatttgaga ggaccccacc tatcatgggg attattattg     1020

atcactttgt ggaccgtccc tatcccagct cctctcccat gcacccctgc aattacagaa     1080

ctgctggtga ggacactgga gtaatatacc cgtctgtaga agactctcaa gaagtgtgta     1140

ccacctcttt ttccacctcc ccaccatccc agctgatggt tcctgggaag gaaggtgggg     1200

taccccttgc tcccaaccag cctgtccatg gtacccaggc tgaccaggag agactggcaa     1260

cctgcacccc ttctgacaga acccactgtg ctgccacacc ctccagtagt gaggatactg     1320

aaaccgtatc aaacagcagt gagggacggg cctcccctca cgatgtcttg gagaccatct     1380

ttgtccgaaa agtgggggct tttgtcaaca aacccattaa ccaggtgacc ctgacgagtt     1440

tggatatacc ctttgccatg tttgctccca agaatttgga gctggaggat accgatccaa     1500

tggtgaatcc tccagattcc ccagagactg aatctcctct ccagggcagc ctgcactcag     1560

atggctccag cgggggcagc agtggcaata cccatgatga ctttgttatg atagacttta     1620

aaccagcttt ttctaaagat gacattcttc cgatggacct ggggaccttc tatcgggagt     1680

ttcagaaccc acctcagctg agcagcctct ccatagatat tggagcacag tccatggctg     1740

aagacttgga ctcattacca gagaagctgg ctgtgcatga gaagaatgtc cgcgagtttg     1800

atgcctttgt ggaaaccctg cagtaaaagt atccttgagt cccagcagca cccccttttt     1860

gtggccccag ggcataagca gcctcccatg catcagctgc tcccacccct catcctgctc     1920

tgagccaggt ggaagggagg ctggcttctc ccatggggac ccagaagtcc ctactcttgg     1980

acctcctgga gactccgtgg cggcagtcaa gcccagtgcc cagttggaga agactcacgt     2040

gctggccttg gagatgggaa gaaccttcgt acgaaaaagc cctcagcagg gccatctgtg     2100

tgccctgccc atcaccaact gcttcccaag ggtgtcatcc tgttcctcct gctgccggcc     2160

tcctgcctgg gcctgccttg cagctggccc cttccctgcc tgctgtcacc atccactgtt     2220

tgacattcca gctggtggcc aagagattgg tgtggagtcg cagaaagagg aaggagacag     2280

tgccaggagg aagaaggaag gagtccctta gctctcttca ttgtcccctt tacttcctgc     2340

tatcttcttc tcctcttctt ctctctcttg cctctatgcc tgtatttctg gcaatatgac     2400

aggcctgcct acccaagatc agaactccaa aaccactccc acccctgaag gtcgggaggg     2460

tctgagcagc cctggtggct gcctgtgctc aggtcctcag ctccatggga aataaaaatg     2520

gcaccctgaa tctctaggat tttgtcactt ggagtcacag caaagttctc ttcctcttgt     2580

ccccccgttg ctgctccttg gttatagaac atggtaaata tttattactt tcagagaaac     2640

cagatatttt atagaggaaa tatgtttgag gtgagttgtt tttcacttgg agaaggcgga     2700

gggctcttcc tgggacggag acctcctcct ccggaggtta ttgagaatcc gggctgctgc     2760

tttgaggatc ttcccaccat acagacagcg agatccaaga agagggctgg ccgggggcaa     2820

agtcacctcc cagtgtggct gcactggaac tgactaaagg ctttaccttg gatagttgcg     2880

tattcctggt gagagcctta catctcccac agtttctgca gagtgactga ctccattctg     2940

gcagcccagg aagtcctggg tgctaaatgt gatggccaca tgtagtggtt aggggatgtt     3000

gtgtgtgtcc cccaactgcc tgggtacttg ttcctgatcc ctggggctgt cctgtggagc     3060

ttttcctcct gcttgggcct agctaccatc tccctctaat cccaggttct ctacactgcc     3120

ctggggttta ccagctggat tggcttctgg ttgagaaatc aaagctgggc gtatgattga     3180

cttaaccctt caggtattgt tacttgaata agtcaagtgc ctagcctcac ccacctatga     3240

tctgtccttt cccagcctcg ctggtagtcc tggtcaagga gatctaggtc tactccattc     3300

ctcctggccc acctggggca ttcactggca gcagctgtgc ttcagtggag caggtggttc     3360

tcagctgctt gttagtatac tgcatgtgac actgttccca catacaaggc tgacttctga     3420

ggattggagc aggctctggc ggggaccaga gctctgcgtg ctgctgctgc caccaagaag     3480

tgttagcaga agcagtagca gccaactggc cctcctgact ttggcccaga gcacatgcgt     3540

ggcttgctga acccaggctc aggtttatcc ccaaggcccc agctttgaga agggggaagg     3600

cccctggtaa gttattgatg cccccatatt tcagctactg ctctctttcc aaggccttgc     3660

atggaaaggc ctagccattg tctgaggcag caatctttgg catctacagg tggcagcagc     3720

ctttcaccag ggctccatct gtgaagagtc tcagccatga ctttgagctg agcttgggag     3780

aagtaaagca actgttaagg ccagcccttg cccctcagac ctgccatgaa aggaatgagc     3840

cctagactga ctcctgcagc acccccggga caggctggga ccagctgttt gtctccaggt     3900

gtcagagtcc ctcctcctcc tccaacctct ccaacctact ttgtttggaa ataccgagct     3960

acacttcaaa atgtattcaa gggatttcca ataaattttt ttctgtactt taca           4014


<210> 4050
<211> 915
<212> DNA
<213> Homo sapiens

<400> 4050
acatctctgc cttctcattt tctcttaatt tttttctttt tttggcttct tggtattctt       60

tgctttcttg gagctcgtca cacatttagg aggatttttg tcttttctgg aatttttagt      120

tgttttttgg tgggagggtc tgtcagtgca tctagtcctc cacactatgg aagcagaagt      180

tggtttaaat tcactttaaa aattgccttc tgttttatca attctgccta aaggtttgtt      240

ggagactgaa ccgttgcaag gaacagacga agatgcagta gccagtgctg acttctctag      300

catgctctct gaggaggaaa aggaagagtt aaaagcagag ttagttcagc tagaagacga      360

aattacaaca ctacgacaag ttttgtcagc gaaagaaagg catctagttg agataaaaca      420

aaaactcggc atgaacctga tgaatgaatt aaaacagaac ttcagcaaaa gctggcatga      480

catgcagact accactgcct acaagaaaac acatgaaacc ctgagtcacg cagggcaaaa      540

ggcaactgca gctttcagca acgttggaac ggccatcagc aagaagttcg gagacatgag      600

acgaaagtag gcggtacgaa ccctaatgga ggcagttttg aggaggtcct cagctccacg      660

gcccatgcca gtgcccagag cttggcagga ggctcccggc ggaccaagga ggaggagctg      720

cagtgctaag tccagccagc gtgcagctgc atccagaaac cggccactac ccagcccatc      780

tctgcctgtg cttatccaga taagaagacc aaaatcccgc tgggaaaaac ccaggccttg      840

acattgttat tcaaatggcc cctccagaaa gtttaatgat ttccatttgt atttgtgttg      900

atgatggacc acttg                                                       915


<210> 4051
<211> 580
<212> DNA
<213> Homo sapiens

<400> 4051
atttgtggca ggtggggcag gctggtcacc tggagcaggt tcctcctctc ccggccccgc       60

cccggcccgg ccccgccgag cgtcccaccc gcccgcggga gacctggcgc cccggccgag      120

gcgcgaacag acggacgcac cggcgagcgc cgaggggaca ggccgagcgc ggggcgccgg      180

aggcaggtgt gggacaggca ctggcctcag accggggcca cactgaggtc tgcccttctc      240

ccgctggccg ccacccaaga caccatgagc cagtccgggg ccgtgagctg ctgcccgggt      300

gccaccaatg gcagcctggg ccggtccgac ggtgtggcca agatgagccc caaggacctg      360

tttgagcaga ggaagaagta ttccaactcc aacgtcatca tgcacgagac ctcgcagtac      420

cacgtccagc acctggccac attcatcatg gacaagagcg aagccatcac gtctgtggac      480

gacgccatcc ggaagctggt gcagctgagc tccaaggaga agatctggac ccaggagatg      540

ctgctgcagg tgaacgacca gtcgctgcgg ctgctggaca                            580


<210> 4052
<211> 389
<212> DNA
<213> Homo sapiens

<400> 4052
gaagtggcca gttcaggagg cggacccccc gagggcagcg ctgcggggcc gttttccggc       60

cctcctgacg cgacactgcc cctctccgag agctgagaag gaaaagagga gcttgcggag      120

gtgttacctc attttgaaag tcttgggaaa caggaaaaaa ttcctaacaa aatgtcagct      180

tttcgaaatc attgtccaca tttggattca gttggtgaaa taacaaaaga agatttgata      240

caaaaatccc ttggtacttg tcaggattgt aaagtccaag gaccaaatct ttgggcatgt      300

ctggagaata gatgttcata tgttggctgt ggtgaatcac aagtagatca cagcaccata      360

cattctcagg agacaaagca ttatctaac                                        389


<210> 4053
<211> 628
<212> DNA
<213> Homo sapiens

<400> 4053
tgcaggtcgg gtggcaccag ctgctgtcct gaggctgcac tggagccgcc cgcaggggct       60

tctgccgggc tcaggccttc tctccagctc gaggctcagt ttggcccagg ctttgcctgc      120

tgggcgtgag ccctaatagc ccatatgggg acgtgattgg cctccaggtg gactactggc      180

tgggccaccc cggggagcgg aggagggaag gcgacaagag ggacgccagc tcgaagaaca      240

ccctcaagag tgtcttccgc tcagtgcagg tgtcccgcct gccccatagt ggggaggccc      300

agctttctgg caccatggcc atgactgtgg tcaccaaaga aaagaacaag aaagttccca      360

ccatcttcct gagcaagaaa ccccgagaaa aggaggtgga ttctaagagc caggtcattg      420

aaggcatcag ccgcctcatc tgctcagcca agcagcagca gactatgctg agagtgtcca      480

tcgatggggt cgagtggagt gacatcaagt tcttccagct ggcagcccag tggcccaccc      540

atgtcaagca ctttccagtg ggactcttca gtggcagcaa ggccacctga ggccctgtct      600

cccagccact ttccctcctg gcactgcc                                         628


<210> 4054
<211> 2771
<212> DNA
<213> Homo sapiens

<400> 4054
tttgggcgct tcgctgatgg tgtcggtgag cgcgtttccc gcctgagcgc aactagcggc       60

gggtcgtggg cacctccagg agagcttgtt tcatatccat atcccactgt attcctgcta      120

atctgctaat gcagtaaatt ggaggaaaac tgttaccagg ataacctgta atgggcaagg      180

agccacaaag aagaaaacat ttcttttaat ttttaaactt ggtttgaaag accagcatgt      240

tttggaaatt tgatcttcac tcatcatccc acatagacac acttctagaa agagaagatg      300

taacactgaa ggagttaatg gatgaggaag atgttttaca ggaatgtaaa gctcagaacc      360

gcaaacttat agagtttctg ttaaaagcag aatgtctcga agatttagtc tcattcatta      420

tagaagaacc acctcaagac atggatgaaa agatcagata caagtatcca aatatatctt      480

gtgagttgct cacttctgat gtctcccaga tgaatgatag actgggagaa gatgaatcct      540

tgctaatgaa attatatagc ttcctcctaa acgattcccc tttgaatcca ctacttgcca      600

gtttcttcag caaggtgcta agtattctta tcagcagaaa accagaacag attgtggatt      660

tcttaaagaa gaagcatgat tttgtagacc ttattataaa gcacatagga acttctgcta      720

tcatggattt gttgctcagg ctcctgacgt gtatcgaacc tccacagccc aggcaagatg      780

tgctgaattg gttaaatgag gagaaaatta tccagaggct tgtggaaata gttcatccat      840

cgcaagaaga agatcgacat tcaaatgcat cacaatcact ttgtgaaatt gttcgcctga      900

gcagagacca gatgttacaa attcagaaca gtacagagcc cgaccccctg cttgccactc      960

tagaaaagca agaaattata gagcagcttc tatcaaatat tttccacaag gagaaaaatg     1020

agtcagccat agtcagtgca atccagatat tgctgacttt acttgagaca cgacgaccaa     1080

catttgaagg ccatatagag atctgcccac caggcatgag ccattcagct tgttcagtaa     1140

acaagagtgt tctagaagcc atcagaggaa gacttggatc ttttcatgaa ctcctgctgg     1200

agccacccaa gaaaagtgtg atgaagacca catggggtgt gctggatcct cctgtgggga     1260

atacccggtt gaatgtcatt aggttgatat ccagcctgct tcaaaccaat accagcagta     1320

taaatgggga ccttatggag ctgaatagca ttggagtcat attgaacatg ttcttcaagt     1380

atacatggaa taactttttg catacacaag tggaaatttg tattgcactg attcttgcaa     1440

gtccttttga aaacacagaa aatgccacaa ttaccgatca agactccact ggtgataatt     1500

tgttattaaa acatcttttc caaaaatgtc aattaataga acgaatactt gaagcctggg     1560

aaatgaatga gaagaaacag gctgagggag gaagacggca tggttacatg ggacacctaa     1620

cgaggatagc taactgtatc gtgcacagca ctgacaaggg ccccaacagt gcattagtgc     1680

agcagcttat caaagatctt cccgacgaag tcagggaacg atgggagacg ttctgcacaa     1740

gctccttagg agaaactaac aagaggaaca cggtagatct agccttttct gattatcaga     1800

tgcaacaaat gacgtccaat tttattgacc agtttggctt caacgatgag aagtttgcag     1860

atcaagatga cattggcaat gtttcttttg atcgagtatc agacatcaac tttactctca     1920

atacaaatga aagtggaaat attgccttgt ttgaagcatg ttgtaaggaa agaatacaac     1980

agtttgatga tggtggctct gatgaggaag atatatggga ggaaaagcac atcgcattca     2040

caccagaatc ccaaagacga tccagctcgg ggagtacaga cagtgaggaa agtacagact     2100

ctgaagaaga agatggagca aagcaagact tgtttgaacc cagcagtgcc aacacggagg     2160

ataaaatgga ggtggacctg agtgaaccac ccaactggtc agctaacttt gatgtcccaa     2220

tggaaacaac ccacggtgct ccattggatt ctgtgggatc tgatgtctgg agcacagagg     2280

agccgatgcc aactaaagag acgggctggg cttctttttc agagttcacg tcttccctga     2340

gcacaaaaga ttctttaagg agtaattctc cagtggaaat ggaaaccagc actgaaccca     2400

tggaccctct gactcccagt gcggctgccc tggcagtgca gccagaagcg gcaggcagtg     2460

tggccatgga agccagctct gacggagagg aggatgcaga aagtacagac aaggtaactg     2520

agacagtgat gaatggcggc atgaaggaaa cgctcagcct cactgtagat gccaagacag     2580

agactgcggt cttcaaaagt gaggaaggga aactgtctac ctctcaagat gctgcttgta     2640

aagacgcaga ggagtgtccc gagactgcag aggcgaagtg cgcggcgccc aggcctccca     2700

gcagcagtcc cgagcagagg actggccaac caagcgcacc aggtgacact tcagtgaatg     2760

gccctgtatg a                                                          2771


<210> 4055
<211> 4292
<212> DNA
<213> Homo sapiens

<400> 4055
cgcttcgctg atggtgtcgg tgagcgcgtt tcccgcctga gcgcaactag cggcgggtcg       60

tgggcacctc caggagagct tgtttcatat ccatatccca ctgtattcct gctaatctgc      120

taatgcagta aattggagga aaactgttac caggataacc tgtaatgggc aaggagccac      180

aaagaagaaa acatttcttt taatttttaa acttggtttg aaagaccagc atgttttgga      240

aatttgatct tcactcatca tcccacatag acacacttct agaaagagaa gatgtaacac      300

tgaaggagtt aatggatgag gaagatgttt tacaggaatg taaagctcag aaccgcaaac      360

ttatagagtt tctgttaaaa gcagaatgtc tcgaagattt agtctcattc attatagaag      420

aaccacctca agacatggat gaaaagatca gatacaagta tccaaatata tcttgtgagt      480

tgctcacttc tgatgtctcc cagatgaatg atagactggg agaagatgaa tccttgctaa      540

tgaaattata tagcttcctc ctaaacgatt cccctttgaa tccactactt gccagtttct      600

tcagcaaggt gctaagtatt cttatcagca gaaaaccaga acagattgtg gatttcttaa      660

agaagaagca tgattttgta gaccttatta taaagcacat aggaacttct gctatcatgg      720

atttgttgct caggctcctg acgtgtatcg aacctccaca gcccaggcaa gatgtgctga      780

attggttaaa tgaggagaaa attatccaga ggcttgtgga aatagttcat ccatcgcaag      840

aagaagatcg acattcaaat gcatcacaat cactttgtga aattgttcgc ctgagcagag      900

accagatgtt acaaattcag aacagtacag agcccgaccc cctgcttgcc actctagaaa      960

agcaagaaat tatagagcag cttctatcaa atattttcca caaggagaaa aatgagtcag     1020

ccatagtcag tgcaatccag atattgctga ctttacttga gacacgacga ccaacatttg     1080

aaggccatat agagatctgc ccaccaggca tgagccattc agcttgttca gtaaacaaga     1140

gtgttctaga agccatcaga ggaagacttg gatcttttca tgaactcctg ctggagccac     1200

ccaagaaaag tgtgatgaag accacatggg gtgtgctgga tcctcctgtg gggaataccc     1260

ggttgaatgt cattaggttg atatccagcc tgcttcaaac caataccagc agtataaatg     1320

gggaccttat ggagctgaat agcattggag tcatattgaa catgttcttc aagtatacat     1380

ggaataactt tttgcataca caagtggaaa tttgtattgc actgattctt gcaagtcctt     1440

ttgaaaacac agaaaatgcc acaattaccg atcaagactc cactggtgat aatttgttat     1500

taaaacatct tttccaaaaa tgtcaattaa tagaacgaat acttgaagcc tgggaaatga     1560

atgagaagaa acaggctgag ggaggaagac ggcatggtta catgggacac ctaacgagga     1620

tagctaactg tatcgtgcac agcactgaca agggccccaa cagtgcatta gtgcagcagc     1680

ttatcaaaga tcttcccgac gaagtcaggg aacgatggga gacgttctgc acaagctcct     1740

taggagaaac taacaagagg aacacggtag atctagttac aacctgccat attcattcat     1800

ccagtgatga tgaaattgac tttaaagaaa cgggtttctc acaggattct tctttgcagc     1860

aaatgcaaca aatgacgtcc aattttattg accagtttgg cttcaacgat gagaagtttg     1920

cagatcaaga tgacattggc aatgtttctt ttgatcgagt atcagacatc aactttactc     1980

tcaatacaaa tgaaagtgga aatattgcct tgtttgaagc atgttgtaag gaaagaatac     2040

aacagtttga tgatggtggc tctgatgagg aagatatatg ggaggaaaag cacatcgcat     2100

tcacaccaga atcccaaaga cgatccagct cggggagtac agacagtgag gaaagtacag     2160

actctgaaga agaagatgga gcaaagcaag acttgtttga acccagcagt gccaacacgg     2220

aggataaaat ggaggtggac ctgagtgaac cacccaactg gtcagctaac tttgatgtcc     2280

caatggaaac aacccacggt gctccattgg attctgtggg atctgatgtc tggagcacag     2340

aggagccgat gccaactaaa gagacgggct gggcttcttt ttcagagttc acgtcttccc     2400

tgagcacaaa agattcttta aggagtaatt ctccagtgga aatggaaacc agcactgaac     2460

ccatggaccc tctgactccc agtgcggctg ccctggcagt gcagccagaa gcggcaggca     2520

gtgtggccat ggaagccagc tctgacggag aggaggatgc agaaagtaca gacaaggtaa     2580

ctgagacagt gatgaatggc ggcatgaagg aaacgctcag cctcactgta gatgccaaga     2640

cagagactgc ggtcttcaaa agtgaggaag ggaaactgtc tacctctcaa gatgctgctt     2700

gtaaagacgc agaggagtgt cccgagactg cagaggcgaa gtgcgcggcg cccaggcctc     2760

ccagcagcag tcccgagcag aggactggcc aaccaagcgc accaggtgac acttcagtga     2820

atggccctgt atgacgggtg acgtctgctg ctgctgactg aggactgcag accgccacca     2880

ctcaggggct ctggaggggt cagctggagc ccaccaagct gtcactgctg cactcactct     2940

gcaagggatc aggaccagca acctttatat tctagattct aagacattgt acagagaaat     3000

tcagaagtgt aaaaatattg cacattgaca aataccaaga atttttgcgt atgtttatat     3060

tgtattgttc taaataatgg gtagcctgtg aaataagatc ttgccaccca tgtaataata     3120

gtagtaatac tatagttaaa atggctgtaa gaatagtttt ataaaagtga atacacagat     3180

ctattgtatt tgaaacataa ctttgacaat tattagtgtg accaaagtat taggcggttt     3240

tcatacattt ttcaccttgt acaaaattat gaattcattt ttcctccagg ccgacaagga     3300

gttgtagaat gaaaatgccc tctaagtgtt attttggttg ttctaactta caaaagtgat     3360

tttgaataag aaatatttgg tgttcttttt ataaccagtt tttgattggt aattgttttc     3420

tgtattgttt aaaacggatc aaaaatgtaa gtctattggt agagattaag taaagtattt     3480

attgctacat catagttgat aaattgatgt tatcgtaaag ccatatgttc tgttcaagtc     3540

ttgtttgctt gaaatgatta ttcctacaag tgaaacacta gactatttgg agtgtatatg     3600

gcttgtgttt tgggattttt tttttttttt tttggctttt gtttttgttt gtttttttgt     3660

ttcatttggt agttcatctg ccttttaacc cattcaccaa aatttacctt gttaacaagc     3720

atcaccaatg aacatttcag agcaatctgc atatttaaca gacctaaaat aaatcctatt     3780

aggcaagtca gttgaaaatg ctcgtgctgc taatggaatt agagtgcgtt cattttacag     3840

gctagtattt taaaagtaga aatcaaaatc tggcaccgaa gcatgctaat tgtttactgt     3900

accttgtgag gttttcactc ataaatttaa accagtgtat ttttttagaa ctggtttgtg     3960

tatatatata gtgattatgg atactaattc aatgtaattt ataattttct atgtcaatac     4020

aaaaatacat cacagccttc tcaaacagct caagcaatat attgtatatt gccatatcgt     4080

ctggtgaaag ggttaaatta cttcacctct tgcactttta gatgcaaatc agtttttcat     4140

ttctgtaata gaaaattatt cacgtatttt tacatcattt gtttttcctg accagtattt     4200

aaaaccaaaa ggatattctg aaaaatggcc aacaattttt ttagaagtag catcccaagc     4260

agcgtgccta aacattacat tgcatatgga aa                                   4292


<210> 4056
<211> 558
<212> DNA
<213> Homo sapiens

<400> 4056
attctgagga tcactgtcct ttagtgatga agtgggtgct gttcctggac ataaaggcag       60

acctgtgctt gacatggatt gatctgtctt ctggcagtga agtgcaggca tgaaccttgg      120

tcagccccac actcttctcc atccgtagcc catgtactag agtttggact tggaccgaag      180

tctggggcag ctccctaatt actagggtgc tgaaggcgtg attgtgccag tcgactgcga      240

gttccttccg cagcttgtat cgttacccac tcctgcaggt gctgctgctg cctccactgt      300

actcagaccc aggtagcaca ggattgtcca tcctccagca gctcagtgca acggtgtgaa      360

ctcagcctgt ttcagagcct ccacaccatg acctccaaga agctggtgaa ctcggtggct      420

ggctgtgctg atgacgctct tgctggcctg gtggcctgca accccaacct gcagctcctg      480

cagggccacc gcgtggccct ccgttctgac ctggacagcc tcaagggccg ggtggcactg      540

ctgtcgggtg ggggctct                                                    558


<210> 4057
<211> 3577
<212> DNA
<213> Homo sapiens

<400> 4057
gggccctcac agaaggcggt ggcgggcggg tgcagcgagt ttgtcccctt gcccgcacac       60

tgcttggcct ctgtacttaa gtgcggtggc cgcctgcctc gctggagctt ctctgccgca      120

gccatccgtg ctgcttggga cgggccgggg cgcgaaggcg gtcgcatcca tcgctctgcc      180

ctcctgcttc tcttgtgtaa tcagctgcct atttggaaat tgggcagggt ttgcgactgg      240

atgctaatgt cactgactag ttttcagcct accatccaga agtaacatgt tcccagcttt      300

ggaaacgcac ctaaagcaga ctattcctga tccttatgaa gactttatgt accgtcacct      360

ccaatattat ggctacttta aagctcagag aggcagttta ccaaactctg ctacgcatca      420

gcatgttcgg aagaataacc ctcaatgcct gttgaatggc tctcttgggg aaaaagatga      480

tttgatacca gacaccctgc aaaaggagaa gcttctatgg cctatcagtt tatcttcagc      540

tgtgcacaga cagatagaag ccatcaacag agactttcac tcttgcctgg gctggatgca      600

gtggcgcggc ctcagctcac tgcaacctcc acctcccaga ttcaaggatt ctcctgcctc      660

agctttccga gtagctggga ttacagattc acatatgctg agtttaccac atcttaggag      720

cagacagctt ctttatgatg agttggatga agtaaaccca cgtcttcgag aaccccaaga      780

gctcttttcc attttgtcta ccaagaggcc actgcaggct ccaagatggc caattgaatg      840

tgaggtcatc aaggaaaaca tccatcatat tgagtgggct ccacctcaac cagaatattt      900

ctatcagcct aaaggaaatg aaaaggtacc agagattgta ggagagaaaa aaggaacagt      960

tgtctatcaa ttagattcag tgcctataga aggttcctat tttaccagtt ccagagtggg     1020

aggcaaacga ggaattgtca aggaacttgc tgtcacgttg caaggaccag aagataatac     1080

tctactgttt gaatcaaggt ttgagagtgg gaatctgcaa aaagctgtca gagtagacac     1140

ctatgagtat gaactcacct tgcgaactga cctctacact aacaaacaca ctcagtggtt     1200

ttattttcgt gttcagaaca ccagaaaaga tgctacctat cgcttcacca ttgtcaactt     1260

gctaaaaccc aagagtcttt atactgtagg gatgaagcca ctcttgtact cccaattgga     1320

tgccaacacc cgcaatattg gctggaggag agaaggaaat gaaatcaagt actacaagaa     1380

caacacggat gatgggcagc agcccttcta ctgtctcacg tggaccattc agtttccata     1440

tgaccaggac acttgcttct ttgcacactt ctacccatat acatacactg atttgcaatg     1500

ctacctcctg tcagtggcaa acaaccctat ccagtctcag ttctgcaagc tccaaacttt     1560

atgcaggagc ctagcaggaa ataccgttta cttgctcacc atcaccaacc catcccagac     1620

ccctcaagag gcagctgcaa agaaagctgt ggtcttgagt gccagagttc accctggaga     1680

aagtaatggc tcctgggtta tgaaaggctt tttggacttc atccttagca actccccaga     1740

tgcccagctc ctcagagata tttttgtctt caaggtgctt cccatgttaa atccagatgg     1800

tgtgattgtg gggaattatc ggtgttcctt ggccggaagg gatttgaaca ggcattataa     1860

aaccattctg aaggagtctt tcccttgtat ttggtacacc aggaacatga tcaaaagact     1920

tcttgaagaa agagaggttc tgttgtattg tgatttccat ggccacagtc gtaagaataa     1980

tatcttcctg tatggctgta ataacaacaa tcgcaaatac tggcttcatg aacgagtctt     2040

tcctttaatg ttatgcaaaa atgcaccaga taagttctct tttcacagtt gtaattttaa     2100

ggtccaaaaa tgcaaagaag gaacaggacg agttgttatg tggcggatgg gaatcctaaa     2160

cagctacacc atggagtcta cctttggcgg gtccaccctg ggtaataaaa gagacaccca     2220

ctttaccatc gaagatctga agtccttagg ttatcatgtc tgtgacaccc ttctggactt     2280

ttgtgatcct gaccaaatga agttcactca gtgtctagca gagcttaagg agcttttacg     2340

acaggaaatc cacaagaaat tccatgaact tggacaagat gtagatttag aaggaagttg     2400

gagtgacatc tctttgtctg acattgaatc cagcaccagt ggctctgaca gttctctctc     2460

agatggtctt cctgttcacc tagcaaacat agcagatgag ctgactcaga aaaagaagat     2520

gtttaagaag aaaaaaaaga agtcacttca gactaggaaa cagcgaaatg agcagtatca     2580

gaaaaaaaat ttgatgcaga agttaaagtt aacagaagat acctcagaaa aggcaggatt     2640

tgcttctact ctgcaaaagc agccaacctt tttcaaaaac tcagagaatt ccagtttttt     2700

accaatgaaa aatgaaaacc caaggttaaa tgagacaaat ttaaatagaa gagacaaaga     2760

cacccccctg gacccatcaa tggccaccct gattctgcct aagaataaag ggagaatgca     2820

gaataagaag ccaggcttta cagtatcatg ctctccaaag agaaccataa actccagcca     2880

agagccagct ccaggtatga agccaaactg gcctaggagc agatatcctg ccacaaagag     2940

aggctgtgct gccatggcgg catacccatc cttgcacata tacacatacc cgtaggtgag     3000

cctgggctgt gccacacaag cacttcatcg ggggttttga gattagacac attttataat     3060

gggggagatg tatgactggg aactgcattt acttgtggta tactgtgttg tgcactcatg     3120

cactgacctt acactttgta cttacactgt gggcatgtgg tcaagatgca tacctcatga     3180

attcaactat tttttcataa aatgaaattt tattatgatg tgtaaaaatg ctttatcaga     3240

aactgaagtg tgttctcatg gcacacttca tggcagcaca gatatacctc attttaacca     3300

atagatattc tctctaaaat tatgtgcaaa tcaattttta aaaatcaaaa tctatgttaa     3360

acacattttg gcagtgtgct ataataaaaa aaagtgttgt gtcaaagctt tctagtgacg     3420

gtcagtccta ctgctgtatg tcaggtttgc tcacaatgag gtattcccac atagaaataa     3480

caatgcatgt attacccaga atttaatgtt gcgtacctta tgttcaatga ggttttgtaa     3540

tttttttagg ctgatgatta aaattctttc tctctaa                              3577


<210> 4058
<211> 1830
<212> DNA
<213> Homo sapiens

<400> 4058
aaagcgttac ttccggcgga aaaggacgcg ggagattcga ttggaaggct gccggcgtgc       60

tactgagttc ggccggtccg agtcactgtg cgtcgcctgg gcccgttcct ggtcttctcc      120

cccagggtct tgctctgtca cccaggctgg agtgccatgg catcatcata gctcactatg      180

gccttgatcc tcctgcctta gcctcccaag cagctggtat tacagatgga gttttgctct      240

tgttgcccag gctgaagtgc catggtgcaa tctcggctca ctgcaacctc cgcatcctag      300

gttcaagcaa ttctcctgcc gcagcctcct gagtagctgg gattacaggc accccccacc      360

atgctcagct actttttgta tttagtggag atggggtttc accatgttgg ccaggctggt      420

ctcaaactcc ctacctcaga ccacggtgtg aacacatgaa cagaagacga aaatttcttc      480

tagcctcagt acttgctctc cagaattcaa gttttatata tccatcatgt cagaagtgct      540

tctctaggat aatcctggtc tccaaaaggt ctaattgtcc aaaatgtggc tctactggtg      600

aatctggaaa tgccaattac agatacaaac tttccttaaa agttgcagaa tcaaacaaat      660

tgtttgttat tactgtattt ggaagttgct tagatacatt ttttggtctt actgccactg      720

gtttgcacag gtacattcag gatcctaata aaattccaga aacactggac aatgatacaa      780

ctcagaatct attaactaaa gcagttgaaa cttgctttgt tggacaaagc tttatttttg      840

gagtgacgaa ttttgaaaac caacctggac aaggttcaga tgccagtaac ttcttacagc      900

aatgctctga ccacaaaaga aaagccaaag cactagtggc ttgccagatt gttctaccag      960

acccagccac ccaagatgct aaaacaaaat aagaccaagg ggaagaagat ggctggggcc     1020

cctgctgtca tgaagaagca agaagccaag aaagtggtga atctcccctg tttgagaaaa     1080

ggcctaagaa ttttagcact ggacaggaca tccaccccaa agggatctca ctcactttgt     1140

caaatggcct cattatatta ggttgcagca gcaaagaact atcctctgta ggtcactgga     1200

agtgcctctt gtgattaacc agtttaccca ggccttggac ctcctaacag ctgctcagct     1260

tcttaagctg gcccacgagt acagaccagt gacaaagcaa gagaagaagc aggaattgtt     1320

ggcccatgct gacaggaatg ctgccagcaa tggagacatc cccactaaga gttcacctgt     1380

ccttcaagca ggggttaata ctgtcaccaa ctcaatggtg aacaagaagt ctcagctggt     1440

gctgactgca caagatatgg atcccatcaa gctggttgtc ttcctgccag ccctgtgttg     1500

taaaatgggg gtcccttact gtgttatcaa agagaaggca aggccgggaa gtttagtcca     1560

caggaggacc tgcatcattg tcaccttcac acaggttaaa tggaaaaaac aaggagcttt     1620

agctaaactt tgggagcttc aggatcaatt acaatgacag atataatgag atccaccatc     1680

aatggggagg caacatcctg ggtccaaaat ctgtggctta caatgccaag ccagaaaaga     1740

caaaggctaa aaaacatgcc actaagctta gttaaatgca cactgttgag ttttctgtac     1800

agaaagataa taaaaaattc tccttcagcc                                      1830


<210> 4059
<211> 564
<212> DNA
<213> Homo sapiens

<400> 4059
ctggtgctgc tatgggcctg tctgcacctc cgtttccctt tctgtgcagg gttaggcttg       60

ctgaggggca ggcacaggag tcctggctga gctcatggcc tgaggctgcc tagcggccac      120

ggggaatggt tgcaatggcg gaggcagagg caggggtggc agtggaggtc cgtggactgc      180

cccctgccgt gcccgacgag ctgctcactc tctactttga aaaccgccga cgctctggag      240

ggggacctgt gttgagctgg cagagactgg gctgtggggg cgtcctcacc ttcagagagc      300

ctgcagacgc cgagagggtc ttggcccagg cagatcacga actacatggt gcccagctga      360

gcctgcggcc agctccacca cgagcccctg cacgcctgct gctccaagga ctgccccctg      420

gcaccacgcc ccagcgcttg gagcagcatg tccaggcctt gctgcgggcc tcggggctcc      480

cagtacagcc ttgctgtgcc ttggccagcc cccggccaga ccgggctctg gtccagttgc      540

ccaagcccct ttctgaggca ggtg                                             564


<210> 4060
<211> 616
<212> DNA
<213> Homo sapiens

<400> 4060
gatcagattc aaggtgacac gcaccagcat acacagaacc acagggctgc ccgggcccgg       60

actgccccac agaggcggca gatgcacaca gaggtcagcc acagcacccc acatggaggg      120

ctgctcaccc acagaggtgc agagggtgcc acctccacca gccaccttga aggagaaata      180

actttatttg gactgagagc tggagaatga gaataggacc tgagagtata ttgggctaag      240

gaggagaggt gtttgagccc agatgagtca tggctggacg acccctccgc ataggagatc      300

agctggttct ggaagaagat tatgatgaga cctacattcc tagtgagcaa gaaattcttg      360

aatttgcccg ggagattggt attgatccca tcaaggaacc agaactgatg tggctggcgc      420

gagagggcat cgtggcccca ctgcctggag agtggaaacc atgccaggac atcacaggtg      480

acatttacta tttcaacttc gccaacgggc agtctatgtg ggaccatcca tgtgacgaac      540

actatcggag cttggtgatc caagagcggg caaagctgtc aacttctggg gccattaaga      600

agaagaaaaa aaaaaa                                                      616


<210> 4061
<211> 1704
<212> DNA
<213> Homo sapiens

<400> 4061
gtcggccgga gcgcgagagc cgggacccgg gctgttggcg gcgcacgccg gggaggttga       60

ggcggaggag cgcgcgttcg ggcgccgcgg acgctgtcct gtagcggtct cgccggcctc      120

ggcgtccgga ctgtggcacc gcgcggggac tccccccgcg cccccgctgc caacgttaag      180

cgagggccaa agcccgccgc ccgcccccca gcatgcgcac ctcgtacacc gtgaccctgc      240

ccgaggaccc ccccgccgcc ccctttcccg ccctcgccaa ggagctgcgg ccgcgctccc      300

ctctctcccc gtccctgctg ctctccacct tcgtggggct cctgctcaac aaagccaaga      360

attctaagag tgcccagggt ctggctggtc ttcgaaacct tgggaacacg tgcttcatga      420

actcaattct gcagtgcctg agcaacactc gggagttgag agattactgc ctccagaggc      480

tctacatgcg ggacctgcac cacggcagca atgcacacac agccctcgtg gaagagtttg      540

caaaactaat tcagaccata tggacttcat cccccaatga tgtggtgagc ccatctgagt      600

tcaagaccca gatccagaga tacgcaccgc gctttgttgg ctataatcag caggatgctc      660

aggagttcct tcgctttctt ctggatgggc tccataacga ggtgaaccga gtgacactga      720

gacctaagtc caaccctgag aacctcgatc atcttcctga tgacgagaaa ggccgacaga      780

tgtggagaaa atatctagaa cgggaagaca gtaggatcgg ggatctcttt gttgggcagc      840

taaagagctc gctgacgtgt acagattgtg gttactgttc tacggtcttc gaccccttct      900

gggacctctc actgcccatt gctaagcgag gttatcctga ggtgacatta atggactgca      960

tgaggctctt caccaaagag gatgtgcttg atggagatga aaagccaaca tgctgtcgct     1020

gccgaggcag aaaacggtgt ataaagaagt tctccatcca gaggttccca aagatcttgg     1080

tgctccatct gaagcggttc tcagaatcca ggatccgaac cagcaagctc acaacatttg     1140

tgaacttccc cctaagagac ctggacttaa gagaatttgc ctcagaaaac accaaccatg     1200

ctgtttacaa cctgtacgct gtgtccaatc actccggaac caccatgggt ggccactata     1260

cagcctactg tcgcagtcca gggacaggag aatggcacac tttcaacgac tccagcgtca     1320

ctcccatgtc ctccagccaa gtgcgcacca gcgacgccta cctgctcttc tacgaactgg     1380

ccagcccgcc ctcccgaatg tagcgccagg agccacgtcc cttctccctt ccccgtggtg     1440

gccccgctcc ctaaattttt taaaaagaca aaaacaaaac aacaacaaca acacacaaac     1500

ctgacaagag aaaaacaaac ctgaagctgc cgagcaggag tggatgcagc ctgatcaggg     1560

tctggagcaa ggagccgggc tttcctgagc tgtggcccgg cagggaagat cgcctggacg     1620

tggagccagc atcgccccgt gccctcggcg tttgcatttg taaacttgtg gtcttcctat     1680

gtgtcagaaa caactgtgtc ttgg                                            1704


<210> 4062
<211> 980
<212> DNA
<213> Homo sapiens

<400> 4062
ctcttcccag cgttcctcct ccggccccag gtcaccgcca gcacgcgcct gcttcccgtc       60

tgcgcgagtc cacgcagctc cccagatcaa gaagctgagg ccccaggtta cacactaaag      120

taaatggcag aggcagaaat aacacctatg tcctcctgac cccaaggccc ttcaccagca      180

cagcagcagc aggcatggca gcaagcgtgg agcagcgcga gggcaccatc caggtgcagg      240

gccaggccct cttcttccga gaggccctgc ccggcagtgg gcaggctcgc ttctctgtac      300

tgctgctgca tggtattcgc ttctcctccg agacctggca gaacctgggt acactgcaca      360

ggctggccca ggctggctac cgggctgtgg ccattgacct gccaggtctg gggcactcca      420

aggaagcagc agcccctgcc cctattgggg agctggcccc tggcagcttc ctggcggctg      480

tggtggatgc cttggagctg ggccccccgg ttgtgatcag tccatcactg agtggcatgt      540

actccctgcc cttcctcacg gcccctggct cccagctccc gggctttgtg ccagtggccc      600

ccatctgcac tgacaaaatc aatgctgcca actatgccag tgtgaagact ccagctctga      660

ttgtatatgg agaccaggac cccatgggtc agaccagctt tgagcacctg aagcagctgc      720

ccaaccaccg ggtgctgatc atgaaggggg cggggcaccc ctgttacctg gacaaaccag      780

aggagtggca tacagggctg ctggacttcc tgcaggggct ccagtgaagc ccagcactgc      840

tgcagggggt gggctgcctg cctgctctga gctctctctt gcacgctctc tcttctctcc      900

caggctctgg ctcatgcaca tgcaacaggt gcgtctgtct atatgtctgg gttcttgtct      960

tttgtggtct gtttgtcttt                                                  980


<210> 4063
<211> 1780
<212> DNA
<213> Homo sapiens

<400> 4063
cttgcttcca cttcaggcct gcctgaggca cttccactgg tctccagtta cttgcaaggt       60

caagtacaac ctgcaaggct ggttatgaag aagaaactca aaataacagg agtggcttat      120

ggaactacat ggagctctgg caggctgccc tgagcacgct caaccccaac cccacggaca      180

gctgtcccct ctacctgaac tacgccaccg tggctgccct gccctgcagg gtgagccggc      240

acaacagccc ctcggccgcc cacttcatca cgcggctggt gcggacctgc ctgccgcccg      300

gagcgcatcg ctgcattgtg atggtctgcg agcagccgga ggtctttgct tccgcctgtg      360

ccctggcccg ggccttcccg ctgttcaccc accgctcagg tgcctctcgg cgcttggaga      420

agaagacggt caccgtggag tttttcctgg tgggacaaga caacgggccg gtggaggtgt      480

ccacattgca gtgcttagcg aatgccacag acggcgtgcg gctagcagcc cgcatcgtgg      540

acacaccctg caatgagatg aacaccgaca ccttcctcga ggagattaac aaagttggaa      600

aggagctggg gatcatccca accatcatcc gggatgagga actgaagacg agaggatttg      660

gaggaatcta tggggttggc aaagccgccc tgcatccccc agccctggcc gtcctcagcc      720

acaccccaga tggagccacg cagaccatcg cctgggtggg caaaggcatc gtctatgaca      780

ctggaggcct cagcatcaaa gggaagacta ccatgccggg gatgaagcga gactgcgggg      840

gtgctgcggc cgtcctgggg gccttcagag ccgcaatcaa gcagggtttc aaagacaacc      900

tccacgctgt gttctgcttg gctgagaact cggtggggcc caatgcgaca aggccagatg      960

acatccacct gctgtactca gggaagacgg tggaaatcaa caacacggat gccgagggca     1020

ggctggtgct ggcagatggc gtgtcctatg cttgcaagga cctgggggcc gacatcatcc     1080

tggacatggc caccctgacc ggggctcagg gcattgccac agggaagtac cacgccgcgg     1140

tgctcaccaa cagcgctgag tgggaggccg cctgtgtgaa ggcgggcagg aagtgtgggg     1200

acctggtgca cccgctggtc tactgccccg agctgcactt cagcgagttc acctcagctg     1260

tggcggacat gaagaactca gtggcggacc gagacaacag ccccagctcc tgtgctggcc     1320

tcttcatcgc ctcacacatc ggcttcgact ggcccggagt ctgggtccac ctggacattg     1380

ctgcaccggt gcatgctggt gagcgagcca caggcttcgg tgtggccctc ctgctggcgc     1440

tcttcggccg tgcctctgag gaccctctgc tgaacctggt gtccccactg ggctgtgagg     1500

tggatgtcga ggagggggac ctggggaggg actccaagag acgcaggctt gtgtgagcct     1560

cctgcctcgg ccctgacaaa cggggatctt ttacctcact ttgcactgat taattttaag     1620

caattgaaag attgcccttc atatgggttt tggtttgtct ttctggtcgt cagcgtggtg     1680

gtggaaacag ctgaagtttt aggagacagc ttagggtttg gtgcgggcca cggggagggg     1740

accgggaagc gctggggctt gtttctgttt gttacttaca                           1780


<210> 4064
<211> 939
<212> DNA
<213> Homo sapiens

<400> 4064
gatttggggc ttgggtcgtt tctcacaagc aaccggaggc ctgcgccgct gccggcgtct       60

cccgggtggg agctcagcgc ggaggctggg gtctcggccg gggacgtgtg gggtgtgccc      120

ggaccctccc ctccgcatcc cgccccttaa gcagctttaa ggggccggag ccggcggcta      180

tttctatccc aggaaatccc cgggccatct gtgaccaaca aaggcccgag cccccccacc      240

cccgcgagcc caacaacagg gcccaacggc ccctggctcc ggggtggggg gatcgggcct      300

ggatcggctg ccggtgcctg ccagtggggg ttaggcttgc tgaggggcag gcacaggagt      360

cctggctgag ctcatggcct gaggctgcct agcggccacg gggaatggtt gcaatggcgg      420

aggcagaggc aggggtggca gtggaggtcc gtggactgcc ccctgccgtg cccgacgagc      480

tgctcactct ctactttgaa aaccgccgac gctctggagg gggacctgtg ttgagctggc      540

agagactggg ctgtgggggc gtcctcacct tcagagagcc tgcagacgcc gagagggtct      600

tggcccaggc agatcacgaa ctacatggtg cccagctgag cctgcggcca gctccaccac      660

gagcccctgc acgcctgctg ctccaaggac tgccccctgg caccacgccc cagcgcttgg      720

agcagcatgt ccaggccttg ctgcgggcct cggggctccc agtacagcct tgctgtgcct      780

tggccagccc ccggccagac cgggctctgg tccagttgcc caagcccctt tctgaggcag      840

atgtccgtgt cctggaggag caggcccaga atctgggcct ggaggggacc ttggtgtccc      900

tggcccgggt tccccaggcc cgagcggtgc gtgtggtgg                             939


<210> 4065
<211> 4322
<212> DNA
<213> Homo sapiens

<400> 4065
cccgctgcct ctggaagaga atcgatcttt tgcgccagcc ctcactgagg gtagagggaa       60

aggcctcatg agaaatcaaa agagagagag taaaacggac atgaaagagg aagatgatga      120

gagtgaagag agtaatgagg ctgaggacca gacaaaagag cagaaggcag aggaaagaaa      180

aaatgagcag gagaaagagc aagaggaaaa tgaagagaaa gaggaggaga agacagagag      240

ccaggggtca aagccagcct atgagactca gcttccatcc cttccctacc ttagtgttct      300

ttcaggtgct gacccagagc tgggttctca gctccaggag gcagctgctt gtggcactaa      360

ctatattgaa gcgtcttgtg ggaaccctcc tatcagccac agggaagctg gtcagagcca      420

gacctcgtgc ctggggaatg gggatcatgg gtgctggcat tgtgggtagg gtgcctttgc      480

ctccctctca caggcctgcc tgtgttactg accaatgtgg agctgggtct agggtgcgaa      540

gaactgcaat ggctgctgca acgggagcag ctgagtccac cccaggtgca gcctggcttc      600

tgtctgtatc tcagcaccac cctctccctc tgtgccatgg aaaaagtgct aggttgtgaa      660

ctgctaaagg ggctgaatgt gttggatctg ggcctgaaca tggaaatact ggaagaacag      720

atgctgcatg aaatcttgtg cagagagtat cctgaactcg agacccgctg gcaggaccta      780

aagatcagag ccctagatac ctgcaaggct gtggaggctg ctgaggagcg gctgctgacg      840

atgctgctgt tccagaatcc gaagcgtcag aagccagcca agtttctgcg gaacatagtg      900

agggcccaag gaaagctatg ccagctgcgt gctcattgtg aagagttaga agggcagaaa      960

ctacaggaga tggtattgtg ggcaccctat cgacctgtgg tttggcatgg aatggccatg     1020

gtaaaggccc taagccaact gcagaacctg ctgccacttt tctgtatgag cccagagaac     1080

tggctggcag tcactaagca ggctctggac agcatgaagc cacgtgagat taatcacggg     1140

gaggacctgg ccagccatct actgcaattg agagcacacc tgacccgcca gctgctgggc     1200

agcaccgtga ctgcactggg ccttacccaa gtacccttgg tgggtgcatt gggcgctttg     1260

gctctgctgc aagcaacagg gaaagcatca gagctggaaa gactggcact ctggcctgga     1320

ctagcagcct ctcccagcac agtccacagc aagccagtct cagatgtggc tcgaccggcc     1380

tggcttgggc caaaagcctg gcatgaatgt gagatgttag agctgctgcc cccatttgtt     1440

ggcctgtgtg cctccctggc aggccactcc agtgcttggc aggcttacct gtcactgtca     1500

tccacagtgc tgggtcctgc acctgggcca gggcctgagc cactcagcct cctccagaag     1560

ctgatcctgt ggcgcgttct gcgacctgag tgcctggcag gtgccctggc agacttcacc     1620

actagcctcc tgggtcggcc cctggatgaa aacacgtatg ctcccaccat gccctttaaa     1680

catagtcagg ctactcagcc catgctgatc ttgttgccac cgcctggcca cccctcagcc     1740

actctgcatc ctctgactgt catccagaaa ctggctgcca agtatcagca ggggcagaag     1800

caactgcagg tgatagccct gggctctgaa gcctgggacc cagtctcagt tgtggtcagc     1860

actctatccc aggctatgta tgaggggcac tggctggtgc tggacaactg tcatctgatg     1920

ccccattggc cgaaagagct gctacagctc ttgctggaac tgttaggcag agccaaggtg     1980

gttgcagacc tggaatcaga acagctttta gaccaacctg aaagcaggaa tgtaagcact     2040

gttcacagag attttcgtct ttggcttatt gtgcctgcag agtctagtgc ttctttgcca     2100

gctgtgctga ctcagcactc catgcctgtt ttctggaacc agtccctgga gctgggccat     2160

gttttgattg acagtgtgga gctagcccag caagtactct acatgcaacc ccccacccag     2220

gcactacctc tgctcctcct ccatggcctc ctgctacacc ggcagctcta tggaacaagg     2280

ctgcaggcac acagggggcg ctggagtcaa gtgactctaa cccaggttct tcagacccaa     2340

gaccagctgt gggcaagtct tagcaatccc cgtgctgcca tgcaagagct ggctggtgag     2400

acccttcctc tcccccttgg agtcatcagc ccccaggaga gcctggaaga gggtgggggt     2460

gggatacaat tcacagcttt ggttttggcg gtggtggaaa ctgaaggtac tggaactgag     2520

agactctaac ctcatcttca gcttcagttt tctacggggg tcctctgggg gacactgagg     2580

acagggaggc cctgattagc ctcacacaag cctgcctgag ccccagtagt gggagctggg     2640

tccagccaca cacacctcag tctttgctgg ccacgctcat gcccctccca ggtaagcctc     2700

actcaggtat ctgttttggg gtagggaata gtgcaatgca atgccacccc ccacagaaat     2760

gtggacagca gtctcaataa aggtatatga gggggtaata ttcatactgt tatgggggtg     2820

atggcagtaa aggctcagag gaaggcctac tctctcgagt ctagggtggg gagagtccat     2880

cttgtccctc acccctcacc tctatcccca agagctaagg gagctggatg caatggcaga     2940

gtgcaaggcc cagatgcacc tactgccctc accacctgaa ccccggctct gcggactgag     3000

tgagggcccc caagcctggc tgttgcgacg ccagagtcgc gctctcttga gtgcgctgca     3060

gcggagttca cccgtgtggg ttcctgagtc tcgaagaggc gcccagcttg cggaaaggcg     3120

actgcggcaa cgcctagtgc aagtcaaccg gaggctggag tcactgcagg atctgctgac     3180

ccacgtgatt cgccaagacg agtccgacgc cccgtggtca gtgctggggc caaatgcacg     3240

gcggcctctg gagggcgtct tagagaccga ggctctagaa ctgagccagt tggtgggcac     3300

gctacaacgc gaccttgatt gcctgttgca gcagctgaag ggcgcacccc cgtgcccctc     3360

ccgccgctgt gctgcggtgg cccacgctct ctggactggc cgcctaccct tgccttggcg     3420

acctcatgcg ccggccggtc cgcagccgcc ctggcactgg ctgcgacagt tgtcgcgccg     3480

tgggcaactg ttggttcgtt acttgggcgt gggcgcggac gcgagcagtg atgtaccaga     3540

gcgcgtcttc cacctgtcag cctttcgcca cccgcgccgc ctgctgctgg cattgcgtgg     3600

ggaagctgcc ctggaccaga atgtgcccag ctcgaatttc cctggtagcc gaggctcggt     3660

ctccagtcag ctccagtata aacgtctgga gatgaacagc aaccctctgc acttcagggt     3720

atcttcgcgc cgcccctcgt tcgcggttcc agtcccctcg aagtctctaa ttacacctcg     3780

cagttacccc ttcttggtga tcttgccccc ggtaaccctg ctagcttctc cgatctcgct     3840

tcaccacgac ctcctacccg ctaaccccca cttcccacct gccacctccc agcttcctag     3900

ccttgcctga ccagcttctg acgcccccag gtggagaatg gtccaaatcc cacggttcca     3960

gagagagggc tgctgctgat cgggctacag gtcctacatg cggagtggga cccaatagct     4020

ggagccttgc aggacagtcc ttccagccaa cccagccctc tgcctcccgt cagcatcagc     4080

acacaggccc cgggcaccag tgacctgcca gccccagccg acctgactgt gtactcgtgt     4140

cctgtgtaca tgggagggcc ccttggcacc gctaagctgc agagcaggaa catcgtgatg     4200

catctgcctt tacccaccaa gctcaccccc aacacctgtg tccaaaggag ggtccatgtg     4260

tgcagcccac ccctgtcttg agcccgtcta ccaaaataaa gttgtagtga ttccatgaaa     4320

ga                                                                    4322


<210> 4066
<211> 1917
<212> DNA
<213> Homo sapiens

<400> 4066
cttccttgct tccacttcag gcctgcctga ggcacttcca ctggtctcca gttacttgca       60

aggtcaagta caacctgcaa ggctggttat gaagaagaaa ctcaaaataa caggagtggc      120

ttatggaact acatggaggt aacagaggag ggtaccaacc aaaggccctt gagcaatcag      180

gatgttggct ctggcaggct gccctgagca cgctcaaccc caaccccacg gacagctgtc      240

ccctctacct gaactacgcc accgtggctg ccctgccctg cagggtgagc cggcacaaca      300

gcccctcggc cgcccacttc atcacgcggc tggtgcggac ctgcctgccg cccggagcgc      360

atcgctgcat tgtgatggtc tgcgagcagc cggaggtctt tgcttccgcc tgtgccctgg      420

cccgggcctt cccgctgttc acccaccgct caggtgcctc tcggcgcttg gagaagaaga      480

cggtcaccgt ggagtttttc ctggtgggac aagacaacgg gccggtggag gtgtccacat      540

tgcagtgctt agcgaatgcc acagacggcg tgcggctagc agcccgcatc gtggacacac      600

cctgcaatga gatgaacacc gacaccttcc tcgaggagat taacaaagtt ggaaaggagc      660

tggggatcat cccaaccatc atccgggatg aggaactgaa gacgagagga tttggaggaa      720

tctatggggt tggcaaagcc gccctgcatc ccccagccct ggccgtcctc agccacaccc      780

cagatggagc cacgcagacc atcgcctggg tgggcaaagg catcgtctat gacactggag      840

gcctcagcat caaagggaag actaccatgc cggggatgaa gcgagactgc gggggtgctg      900

cggccgtcct gggggccttc agagccgcaa tcaagcaggg tttcaaagac aacctccacg      960

ctgtgttctg cttggctgag aactcggtgg ggcccaatgc gacaaggcca gatgacatcc     1020

acctgctgta ctcagggaag acggtggaaa tcaacaacac ggatgccgag ggcaggctgg     1080

tgctggcaga tggcgtgtcc tatgcttgca aggacctggg ggccgacatc atcctggaca     1140

tggccaccct gaccggggct cagggcattg ccacagggaa gtaccacgcc gcggtgctca     1200

ccaacagcgc tgagtgggag gccgcctgtg tgaaggcggg caggaagtgt ggggacctgg     1260

tgcacccgct ggtctactgc cccgagctgc acttcagcga gttcacctca gctgtggcgg     1320

acatgaagaa ctcagtggcg gaccgagaca acagccccag ctcctgtgct ggcctcttca     1380

tcgcctcaca catcggcttc gactggcccg gagtctgggt ccacctggac attgctgcac     1440

cggtgcatgc tggtgagcga gccacaggct tcggtgtggc cctcctgctg gcgctcttcg     1500

gccgtgcctc tgaggaccct ctgctgaacc tggtgtcccc actgggctgt gaggtggatg     1560

tcgaggaggg ggacctgggg agggactcca agagacgcag gcttgtgtga gcctcctgcc     1620

tcggccctga caaacgggga tcttttacct cactttgcac tgattaattt taagcaattg     1680

aaagattgcc cttcatatgg gttttggttt gtctttctgg tcgtcagcgt ggtggtggaa     1740

acagctgaag ttttaggaga cagcttaggg tttggtgcgg gccacgggga ggggaccggg     1800

aagcgctggg gcttgtttct gtttgttact tacaggactg agacatcttc tgtaaactgc     1860

tacccctggg gccttctgca ccccggggtg aggcctcctg cctgcctggt gccctgt        1917


<210> 4067
<211> 862
<212> DNA
<213> Homo sapiens

<400> 4067
ctgattggtt agtttccagg cccaaaacca gaggtctctc agacatttgt ttcaaacggc       60

tgattgaggg agttcagggg ttgggggttg gcggttcttg cccagtttag cttgggatca      120

acagctccaa caacgtgtcc aatcaacaac agcttgattg taaaaagtcc tgaatctgct      180

ggatgatgaa ataattttga atggataatt aaagctcaaa gtttcagaat cagattccta      240

taggcaatgg aaactgatct caattcccag gacagaaagg acctggacaa gtttattaaa      300

ttttttgccc tcaagactgt ccaagtgatt gtccaggctc ggcttggtga aaagatttgc      360

actcgttcat catcttctcc aacgggttca gattggttca acttagcaat caaagacatc      420

ccagaggtta cacatgaagc aaagaaggca ctggcaggac agctgcctgc agtcgggagg      480

tccatgtgtg tggagatttc acttaagact tctgagggag attccatgga gctggaaata      540

tggtgtcttg aaatgaatga aaagtgtgat aaagaaatca aagtttccta cacggtgtac      600

aacagactgt cattgctgct gaagtccctt cttgctataa ctagggtgac accagcctat      660

aggctctcca ggaaacaagg gcatgaatat gtcatattat acaggatata ttttggagaa      720

gttcagctga gtggcttagg agaaggcttc cagacagttc gtgttgggac agtgggcacc      780

cctgtgggca ccatcactct ttcttgtgct tacagaatta acttggcatt catgtctacc      840

aggcaatttg agaggacccc ac                                               862


<210> 4068
<211> 556
<212> DNA
<213> Homo sapiens

<400> 4068
atctcttctg caccttgtgc attgtaggtt ttggatgctt atttgtttag ggtctaggac       60

ctggtgctta gcctctcctg gatcctgtat atttactgac tttccaaatt cttttgagtg      120

tggcattata tctgcttcat cttctctttc ttggctattc ttagtgccct tctcatttta      180

ctgtcctaat gttttcccat ttatactatg aatcattgtg caccctatgt agagcctgtc      240

attggagatt aaaatcagtg gcagctcttt gattttacag ctcagcctca gctgaacata      300

acttcttttt ttcaaagttc cctgtgttgt gaactgagct tgggtgaagt gaaatctttg      360

aggaagctaa agctgtgtgt atttgtggat cagacaagtg cagcaagtta atatcattgg      420

cttctgaagg ggagagtgag gtgatggctg cgtttaagtt ggatttcctt ccagaaatga      480

tggtggatca ttgctctttg aattccagtc ccgtctcaaa gaaaatgaac ggcaccctgg      540

accacccaga ccaacc                                                      556


<210> 4069
<211> 4199
<212> DNA
<213> Homo sapiens

<400> 4069
gaagcggatg aaaacaaaca ctaacgatgg cggcgccggg aagcgaccgg ctgctgggct       60

taaggcggga gtgaccgctt aaccagtgag ggaagcactg aagagcgcca gtcgacgtgg      120

gtgcgacaac tcgcggagtc ttaggagcaa aacgtctggg gcctgcgagc caggaccctt      180

ctgaagcctt aggtgtctat cggcgacgtg tacggtcact gcagctccgg agcgcggaac      240

cctcagccag gaggcgcggc tggtcggtcc caggtcccgg cctccgtaat gagagcccgg      300

aaccactctt tgtgccgcag cttcgcaggt gagggtgact gttgactagt gaaaaaaggg      360

acccatggtt cacgactgtc ttcttactgg cagtggaacg acctgtggaa acctgtgatc      420

cattctcatt aaataaatct ctggattcct ataggcaatg gaaactgatc tcaattccca      480

ggacagaaag gacctggaca agtttattaa attttttgcc ctcaagactg tccaagtgat      540

tgtccaggct cggcttggtg aaaagatttg cactcgttca tcatcttctc caacgggttc      600

agattggttc aacttagcaa tcaaagacat cccagaggtt acacatgaag caaagaaggc      660

actggcagga cagctgcctg cagtcgggag gtccatgtgt gtggagattt cacttaagac      720

ttctgaggga gattccatgg agctggaaat atggtgtctt gaaatgaatg aaaagtgtga      780

taaagaaatc aaagtttcct acacggtgta caacagactg tcattgctgc tgaagtccct      840

tcttgctata actagggtga caccagccta taggctctcc aggaaacaag ggcatgaata      900

tgtcatatta tacaggatat attttggaga agttcagctg agtggcttag gagaaggctt      960

ccagacagtt cgtgttggga cagtgggcac ccctgtgggc accatcactc tttcttgtgc     1020

ttacagaatt aacttggcat tcatgtctac caggcaattt gagaggaccc cacctatcat     1080

ggggattatt attgatcact ttgtggaccg tccctatccc agctcctctc ccatgcaccc     1140

ctgcaattac agaactgctg gtgaggacac tggagtaata tacccgtctg tagaagactc     1200

tcaagaagtg tgtaccacct ctttttccac ctccccacca tcccagctct caagctctcg     1260

cctttcctat cagcctgctg ccctgggcgt tggatcagct gacctggctt atccagtagt     1320

gtttgctgct ggcttaaatg ctacacaccc tcaccagctg atggttcctg ggaaggaagg     1380

tggggtaccc cttgctccca accagcctgt ccatggtacc caggctgacc aggagagact     1440

ggcaacctgc accccttctg acagaaccca ctgtgctgcc acaccctcca gtagtgagga     1500

tactgaaacc gtatcaaaca gcagtgaggg acgggcctcc cctcacgatg tcttggagac     1560

catctttgtc cgaaaagtgg gggcttttgt caacaaaccc attaaccagg tgaccctgac     1620

gagtttggat ataccctttg ccatgtttgc tcccaagaat ttggagctgg aggataccga     1680

tccaatggtg aatcctccag attccccaga gactgaatct cctctccagg gcagcctgca     1740

ctcagatggc tccagcgggg gcagcagtgg caatacccat gatgactttg ttatgataga     1800

ctttaaacca gctttttcta aagatgacat tcttccgatg gacctgggga ccttctatcg     1860

ggagtttcag aacccacctc agctgagcag cctctccata gatattggag cacagtccat     1920

ggctgaagac ttggactcat taccagagaa gctggctgtg catgagaaga atgtccgcga     1980

gtttgatgcc tttgtggaaa ccctgcagta aaagtatcct tgagtcccag cagcaccccc     2040

tttttgtggc cccagggcat aagcagcctc ccatgcatca gctgctccca cccctcatcc     2100

tgctctgagc caggtggaag ggaggctggc ttctcccatg gggacccaga agtccctact     2160

cttggacctc ctggagactc cgtggcggca gtcaagccca gtgcccagtt ggagaagact     2220

cacgtgctgg ccttggagat gggaagaacc ttcgtacgaa aaagccctca gcagggccat     2280

ctgtgtgccc tgcccatcac caactgcttc ccaagggtgt catcctgttc ctcctgctgc     2340

cggcctcctg cctgggcctg ccttgcagct ggccccttcc ctgcctgctg tcaccatcca     2400

ctgtttgaca ttccagctgg tggccaagag attggtgtgg agtcgcagaa agaggaagga     2460

gacagtgcca ggaggaagaa ggaaggagtc ccttagctct cttcattgtc ccctttactt     2520

cctgctatct tcttctcctc ttcttctctc tcttgcctct atgcctgtat ttctggcaat     2580

atgacaggcc tgcctaccca agatcagaac tccaaaacca ctcccacccc tgaaggtcgg     2640

gagggtctga gcagccctgg tggctgcctg tgctcaggtc ctcagctcca tgggaaataa     2700

aaatggcacc ctgaatctct aggattttgt cacttggagt cacagcaaag ttctcttcct     2760

cttgtccccc cgttgctgct ccttggttat agaacatggt aaatatttat tactttcaga     2820

gaaaccagat attttataga ggaaatatgt ttgaggtgag ttgtttttca cttggagaag     2880

gcggagggct cttcctggga cggagacctc ctcctccgga ggttattgag aatccgggct     2940

gctgctttga ggatcttccc accatacaga cagcgagatc caagaagagg gctggccggg     3000

ggcaaagtca cctcccagtg tggctgcact ggaactgact aaaggcttta ccttggatag     3060

ttgcgtattc ctggtgagag ccttacatct cccacagttt ctgcagagtg actgactcca     3120

ttctggcagc ccaggaagtc ctgggtgcta aatgtgatgg ccacatgtag tggttagggg     3180

atgttgtgtg tgtcccccaa ctgcctgggt acttgttcct gatccctggg gctgtcctgt     3240

ggagcttttc ctcctgcttg ggcctagcta ccatctccct ctaatcccag gttctctaca     3300

ctgccctggg gtttaccagc tggattggct tctggttgag aaatcaaagc tgggcgtatg     3360

attgacttaa cccttcaggt attgttactt gaataagtca agtgcctagc ctcacccacc     3420

tatgatctgt cctttcccag cctcgctggt agtcctggtc aaggagatct aggtctactc     3480

cattcctcct ggcccacctg gggcattcac tggcagcagc tgtgcttcag tggagcaggt     3540

ggttctcagc tgcttgttag tatactgcat gtgacactgt tcccacatac aaggctgact     3600

tctgaggatt ggagcaggct ctggcgggga ccagagctct gcgtgctgct gctgccacca     3660

agaagtgtta gcagaagcag tagcagccaa ctggccctcc tgactttggc ccagagcaca     3720

tgcgtggctt gctgaaccca ggctcaggtt tatccccaag gccccagctt tgagaagggg     3780

gaaggcccct ggtaagttat tgatgccccc atatttcagc tactgctctc tttccaaggc     3840

cttgcatgga aaggcctagc cattgtctga ggcagcaatc tttggcatct acaggtggca     3900

gcagcctttc accagggctc catctgtgaa gagtctcagc catgactttg agctgagctt     3960

gggagaagta aagcaactgt taaggccagc ccttgcccct cagacctgcc atgaaaggaa     4020

tgagccctag actgactcct gcagcacccc cgggacaggc tgggaccagc tgtttgtctc     4080

caggtgtcag agtccctcct cctcctccaa cctctccaac ctactttgtt tggaaatacc     4140

gagctacact tcaaaatgta ttcaagggat ttccaataaa tttttttctg tactttaca      4199


<210> 4070
<211> 1410
<212> DNA
<213> Homo sapiens

<400> 4070
ctttcaaagc caatttgaat aaacaactct tccctctcaa atgggcaaga gtaactcttc       60

agcaccatgg agaggtccgg gcagcgtgtt acaacgtggg actgtgacca gggcaagcac      120

tctgacagtg cacagaaaaa tgagagagag tctatcagac agaagttggc acttggaagc      180

ttctttgatg atggcccagg aatttatacc agctgtagca aaagtgggaa gccaagcctt      240

tcctcccgac tgcagagtgg gatgaacttg cagatatgct ttgtcaacga cagtggcagt      300

gataaggaca gtgatgctga tgacagtaag actgaaacca gcttggacac ccccttgtct      360

cccatgagca aacagagttc ttcctattct gatagagaca ctactgaaga ggagtctgaa      420

tccttggatg acatggactt ccttacaagg caaaagaaat tgcaagctga agccaaaatg      480

gcccttgcca tggccaaacc aatggccaaa atgcaagtag aagtggagaa acagaacagg      540

aaaaagtctc ccgtcgctga tcttctgcca cacatgcctc atataagtga atgcttgatg      600

aaaagaagtt taaaacccac cgacctgaga gacatgacta ttgggcagct acaagtgata      660

gtcaatgatc tccattccca gatagaaagc ttgaatgaag agttggtcca gctgcttctc      720

atccgagatg agctgcacac agagcaggat gccatgctgg tggacattga agacttgacc      780

agacatgctg aaagtcagca gaagcacatg gcagagaaaa tgcctgcaaa gtgaaaagaa      840

gccattcaac cagagaacaa gctagaattt attttgcttc tgtggttgta aaaatgctgt      900

tgctaaaggt ggcgcagaaa caaatatcag tgttagtcat tgataatgtc tgaagcttaa      960

tgtccagtga ttggcctttg cttcttaatt tattttaatt ttttacttgt gccacttaat     1020

atcaggcatt ttaataaaat attgttacaa aaaatgtaca gtactgacac caccacaaat     1080

catggttaat aaaagagagt agttttaact ttatttttat ttgtttagag attttaagtt     1140

ggaacagtat tttcccattg actacttttc attcttcact gtagttttaa agaagaactg     1200

taaatgacgg tgctatacaa gtcaaaaaat acatgcctgc ctcgtagtga agttgtagct     1260

ctccgtaata tgtatatttt actcagtttt caacattttg tgaatgttga ctacctgaag     1320

ttccttttta gatgtgctat taacattctg ttggattcag agggttcctt gaaagtttta     1380

tgtataaata tgtaaaataa aaattaaaac                                      1410


<210> 4071
<211> 540
<212> DNA
<213> Homo sapiens

<400> 4071
attcccaccc ctacccagga ccggcagccg gagccttggg tccctgcatg ggcctggggc       60

gccctgtgcc ccttcacctc gtcctcgtcc agttgactgc tgtggcagcc ggtgctaccc      120

gctgtgtcca ctgcaccctg gccctgttct gagcggtcac agcagctggg gagaagggcc      180

atcctggaag ccgggcagat gaggacggaa ccagacagtc ccactgtggt gggcagaggt      240

tcctcctctc ccggccccgc cccggcccgg ccccgccgag cgtcccaccc gcccgcggga      300

gacctggcgc cccggccgag gcgcgaacag acggacgcac cggcgagcgc cgaggggaca      360

ggccgagcgc ggggcgccgg aggcaggtgt gggacaggca ctggcctcag accggggcca      420

cactgaggtc tgcccttctc ccgctggccg ccacccaaga caccatgagc cagtccgggg      480

ccgtgagctg ctgcccgggt gccaccaatg gcagcctggg ccggtccgac ggtgtggcca      540


<210> 4072
<211> 525
<212> DNA
<213> Homo sapiens

<400> 4072
gtgctgcagc ccgagctcga ggggggagcg ccgcctccgc aggcctcctg agacccgggc       60

ggctggggac gcagacagac acctgaggga gggaagagcg cgcacccagg aggagtctat      120

tggcctaccc gcagggggag gccgagatgg ggagactgag gcagatgaat ggtgctggaa      180

ggaaaccctg aagtggggtc cccccgaacc tcagacctcc agcaccgggg gaacaagggc      240

tcttgcgttc tctcctctcc cggtgaagat gcgcagccag gcgaggagcc catcaagtat      300

ggtgaactca tcgtcctggg atgctgtgag gaaggaggtg aggaaaccga ggctcagaga      360

ggggaagtga ctggcccaag ggcacacagc tgctacaatg gttgtctggc aagtggggac      420

aagggccgcc ggcgaagccg cctggcactg agccgccggt cgcacgccaa cggggtgaag      480

ccagacgtca tgcaccacat ctccacgccg ctcgtctcca aggca                      525


<210> 4073
<211> 585
<212> DNA
<213> Homo sapiens

<400> 4073
gcgctcgagt gtgggcgggg actgagggaa gaagtgaaaa tcggactgcc aggcgacagt       60

tcctccgttt gaaatctcgc cggctcctga gcgggccacc gggcccgggc tgggggtctg      120

gcgggagaaa taactttatt tggactgaga gctggagaat gagaatagga cctgagagta      180

tattgggcta aggaggagag gtgtttgagc ccagatgagt catggctgga cgacccctcc      240

gcataggaga tcagctggtt ctggaagaag attatgatga gacctacatt cctagtgagc      300

aagaaattct tgaatttgcc cgggagattg gtattgatcc catcaaggaa ccagaactga      360

tgtggctggc gcgagagggc atcgtggccc cactgcctgg agagtggaaa ccatgccagg      420

acatcacagg tgacatttac tatttcaact tcgccaacgg gcagtctatg tgggaccatc      480

catgtgacga acactatcgg agcttggtga tccaagagcg ggcaaagctg tcaacttctg      540

gggccattaa gaagaagaaa aaaaaaaagg aaaagaaaga caaga                      585


<210> 4074
<211> 568
<212> DNA
<213> Homo sapiens

<400> 4074
ttcttgctgc tgccatgtga agaaggacgt atttgcttcc ccttctgcca cgatgggaag       60

ttttccgagg cctccgccac tatgctgaac tagagcgaaa tgtcatcagt gcagtcacaa      120

caggagcagt tgtcccagtc agatccatct ccgtcaccaa actcatgtag ttcctttgag      180

ctaatagaca tggatgctgg cagcttgtat gaaccagttt ctccccattg gttttattgt      240

aagataatag attctaagga gacatggatt cctttcaact ctgaggattc acagcagctg      300

gaagaggcat atagctctgg aaaaggttgt aatgggagag ttgttcctac tgatgggggc      360

agatatgatg ttcatttggg ggagaggatg cggtatgctg tatactggga tgaactggca      420

tcggaagtga gacgatgtac gtggttttac aagggggaca aagacaataa gtatgttccc      480

tactcggaga gcttcagcca agttttagag gaaacttaca tgcttgctgt aactttggat      540

gaatggaaaa agaaactgga atctccca                                         568


<210> 4075
<211> 14298
<212> DNA
<213> Homo sapiens

<400> 4075
atggtcccgg aggagaggag ggtaggtttg tcttctgatg agacatcatc tgattccctt       60

aagtcttggc actccatatg tgtcttggac agcaaagaac agcccttggc ctgccagcag      120

aaacagaggc agttcgtgaa gccagtgact gagtcagagc agcccacagt gctggaactc      180

ctgctagctg agctccgaac tctgttctca gctgtgttgc aggacagtag ccctgcagct      240

tggcgctatc ttcatgcagt actgggtcta ctgcctccat atcgtgagtt gctagttggc      300

caccttgatt tgctgccctt cctggagcag ctgtactgct gggcaccctg ggtccaaacc      360

cacctccatc tggacctgct aggtgccatt gtccaggcct ttcctccaga cagctctttg      420

ttagacagtg cttcccatgc tgactgctgt ccccagaagc ggaggctcca tcacaggccc      480

ccatgcccag cttgcccttt tgtgcaggcc cagtggagca ggcagcaagt aaaggaggag      540

ctggccacct ggctgcgacc attgacactg cctgagctac agcgctgcct gggcattgtt      600

ggtgctcagg tggccctaga agaggctgtg tggctggatg gacttagtct ccttcccttg      660

gcactggcag cggacatccc tgtacggtat gaaagcagtg acactgacaa tgcagaggtg      720

gagcctgttg gaagaaaaga gaccaggtct cagcttgact atgaagttcc cagggaaaag      780

gccttccaaa agagcagcac cggcttttca cctgagactt ccttcctgga tagccaggtg      840

atgactgctc tgaagatgga gagatacctg aagaagatcc acttcctcta tctcaatgtg      900

gctcccagcc ggtactttag gccttacagc ctgatggtgg tgccacccga caaggtgaat      960

cccgagcact acatcttctc tccctttggg atcttgcatg tacatcctgt ggaaggtagc     1020

gagacgatga cactgggtac ctggcaccat cactgtgttc tctggcagca gctccagttc     1080

attccattct ttaagtattg cctcttacgc aagtccttta cctgttggaa gaagaatgtg     1140

agattacagg ggctgcatcg actccagaaa ttcctagaga atcatctgct cttggctgtg     1200

ccccactttg gagctgggct actccatatt agcaggcttc tgcaggagct acactctgtg     1260

tcctggctac cccaggaact ggatcggtgc tatgagctgc tggacctgca gacggctcta     1320

gccgaggaga agcataaggc tctacggctg ctccatcgtt gcctaaacct ctgcacatcc     1380

attcttcgac tggttcacga ggacacatac cacatgcaac agtgcctaca ggagcgagta     1440

caaaactgtg acaggatcag gacaggccaa ggctccatat accttcagag ggtacagcac     1500

aagcaactgg agcagaagct gaagcaagca gaggcctggt ggctgcagct gggaaagttt     1560

gcccgcctgg ttgactacat gatttgtcag agcctcattt ctgtcttgga agagcagata     1620

acctcttttg tggccaacat ccttcaagcc ccaaggcaga aaccctttct ctcatcacag     1680

ctggtctttg atgatcatgg tcaactgtct catgtgccct gtgttgaaaa tatgatccag     1740

actctaactg gaggcctaca gtctgtcaag acctctgcct tgcaggtagt gcagtctgca     1800

gacctgaaga cctcctcgga ttccctgtat tctgaagaag aagatgaaga ggaggactca     1860

aaagacgaat ttctgatgcc caagttccag ggccagccca gcgatgctgt gagcatcttc     1920

tgtggcccga atgtgggatt ggtgtggccc tggaagtctc acccaattgc tggtatcttg     1980

gaggtccgtg gatgtcggct gcggggccaa tacttccccc acaattataa gcagctggag     2040

gaagacctgg acaacaaccc taagatccag caggcactga atatacaaca ggtgctgctg     2100

gagggcgtgc tgtgcaaggt gcaggaattc tgcagggaac atcattggat aacaggcatt     2160

tatgaattcc tgcaatcctg ggggcctcag aagctggaag acatgagagg tggtcccatc     2220

aagaactacg tgacgctggt gagccgcctg aatgtttggc aggcccgtgt ctccagtatg     2280

cctatcgagt tgctcacaaa aggcgggttg ctgctactta gctgccatga tgtacaggca     2340

gagatggaat ccaagctgaa cagcataagg aaggacattc ttgcacacgt gcaaaatgag     2400

tgctggaacc tcagtcaaca actcatgaca gagctcacag atttcatgca tatcttccga     2460

accatcaact cagatattca tgccattgca cagtgcaccc agaagttgaa tgaagccaat     2520

gaacagtacg tcgagctgga ggagcgaatg gaatacgtac gggcactcca cgaactcatc     2580

cgcaaccact ttagcctctt tagtgctgag aatgaagcac tggacatctc ggtgagaagg     2640

caattcgggg agtcacccat ccctccctgc cctcctcccc cacaaccaca tctactccac     2700

tgccctctgc ttgccccaca gcttctggat atgtgggagg catttcagtt tgagaaaagc     2760

caggcttcag agttcctgct cagcaagcga catgccatta tgcccaagct gcagcagctg     2820

atggcagcag cattggcaga gctggaaggc ctgcttgcga aggccctctc cggtcccttt     2880

atggacccca cacaagatca gaggagtact gagcaccagc tcgtctccct agagcgtcag     2940

ttccagaaca cagtcagcga cctcagtgaa ctgcaccacg cctatgccat cttcactgag     3000

gatgagactc ctgtgccctt gccaatctgt gggacacgtc ctattgtgca gcagcagcgc     3060

atatggcacc tgtaccgagt catctccgaa aacatcagcg agtggaagtg catggctttt     3120

gccaagttca gcccagctat ggcccaggag aagacagagg gctggctgac agaggcagca     3180

cggatgagca caaccctgga gctgcacagc cccgtgctgc agcactgcat gcgcatcctg     3240

ggggagtttc gcagctacct gcccctgctc actaagctgg gcagcctcca cccacagagc     3300

ctcaactgcc agtgtctcct gcgtgccctt gggctgggca gtctccaaac tatagaactc     3360

ctaacgctgg gccagctgct tacttatcca ctgctggagt ttgcagatcg aatcaaccag     3420

gtctggcaga atgaaaatga acgaattcat gcccaagaga ctatacggcg gttgcagcgg     3480

tactgggaag cgcgccagct gcgcctgctc aacttcatcc tgcatgtacc ctacgagccc     3540

ccagcctcag agcgctccaa gaggcaggtg ctccgcagcc cccaatggga ggtagtggac     3600

aaagatagtg gcaccttcat cctctcagat tacagcaacc tgcaggattc catccaggaa     3660

agtcttcagg tgttgtccaa gatcttggcc atcgaaaagt caggagattt aaacaaaata     3720

gctttggagt gggtggccat catgcatggc ctgggtgccc tgctggaggt gtggctgact     3780

ttccagcaga agtggatttt tctgaataaa gttctgcatg agatgaagat ccagtttcct     3840

aatgctgacc tgaactctcg tttcaaggtc atggatgacc agtatcgaac cctgatgcgc     3900

atctctgtag ctgaccccat ggttctgtca cttgtagtgc ccagtgccga gaggagccct     3960

tacttccaag gccagcagct gcaacaactg ctgcaagcag gatcggtgga gctggagggc     4020

atcatcatga gtctggagag cgtgctctat ggggtgtgtg ctcacttccc ccgcctcttc     4080

ttccttagtg acagtgagct ggtagccctg ctggctgctc gactggaatc atgcgaagcc     4140

cagctatggg tacgacgctg ctttcctcat gtgcatgctg tgagcttcag gtcttgccca     4200

actggtgaga aaaacacaga tgactgggag tcaagcccaa acacacagac tcaggtggag     4260

gcacttgcag tgctaggggc aggtggggag gaggtgaagc tgcagggtcc ccttcctctg     4320

catccagatc tccctaagtg gctggcctct ctggagaagt gtctgcgctt ggcactggtg     4380

cacatgctgc agggctgtgt ggctgctcgc cttgctcgag gcccatctct aggtgaggcc     4440

ctcaagcaac tgcccaagca aaacaagttg tacctgcaac tgtatgtcca gcactggatc     4500

gacttagtcc aggccttccc atggcagtgt gtgctggtgg cagaggaggt ggtatggcgg     4560

gccgagatgg aggaggctct gcttgagtgg ggtaccctgg ccatggtctc catgcatatg     4620

cgcaagcttg aggtactggt gaattttatg cgggcccaga gggcttccca aggtgggcag     4680

tccctgcctt ctgtccgcca gaccagcctt ctcagtgccc tgctggtcat ggcagtgact     4740

caccgggata tagcacagct gctggaacag caccaggtca gtgatctcac agactttcac     4800

tgggtccgcc aactcaagta tcacttgggt tcacctcaca taatccccaa aagcccccta     4860

cagagtctta agactattgc atcttctgaa ccctctctgt caccagcggc atgctggata     4920

gatgtgctag gcaggtcctt cctgtacaat tacgagtatc tgggacctag actagggcct     4980

ctacccagcc tactgcctga acggccagcc ctggtactat tattggccct agaggaggtg     5040

gcctgtggga ccgtactggg tcctaatggt gtgggcaaga gagctatagt gaacagcctg     5100

gcacaggccc tgggccgcca gctggtgatg ctaccctgct cacctcagat agaggctcaa     5160

tgcctgagca actatctgaa tggtgccctg cagggtggtg cctggctgct gttggagaaa     5220

gttcatcagc tgccccctgg cttgctctct gccctgggcc agcgcctggg tgaactgcac     5280

cacttgtatg ccccactgta ccaggaggct tcccgaaaca caagcaccat agaccccacc     5340

cagccccagc tccttggcag tagcttcttt gaaaaacatc acgtgtctgt gcgccttggc     5400

tatggctgtc tcctggtact gcgtgccctg agctctgctg tgcctgccaa cctgcacctg     5460

ctgctgcggc ctgtggcatt ggcattgcct gatctgcggc aagtggcaga gctgactctg     5520

ctgggtgcag ggatgaggga tgccttccag atggctaccc gcctatccaa attcttctct     5580

ctagagcgtg agctggtgtc tgggcccctg ccctgccgcc tgccactgct caagcagata     5640

ctggaagaca caatacggac actaaatgtg accaaggagg aaccgaagtg ccagaagcct     5700

cgcagcctag ctgccattga ggaggctgcc ctactgcgct caccactgtt tagcattctc     5760

aatgggctcc acctgcacaa cctccgaggg ctgttgtgtg cgcttttccc tagcgccagc     5820

caagtgctgg cagaacctat gacttacaag ctgatgaagc cattggtggt ggaggaactg     5880

caacaggtag gtctggatcc cagccctgac attttggggt ccttggaaca gttgagccag     5940

gccctgagcc gggcctcagg cattctgctc ctgggccctg cgggcagcgg caagaccact     6000

tgttggcaca gcttatttaa gatccagaat cggctggcag ccatggagga cacctcaacc     6060

caaggctgcc agcctgtgga aattacccac ctgtacccca gtggcctcag cccccaggag     6120

ttcctgggat ggctagaggg ctcctgctgg catcatggca tctttcccaa ggtacttcgt     6180

gcagccggtc agtgtaacaa catgggccaa aagaggcaga cagaggaatc aatcgggatc     6240

cagcactgga taatatgtga tggagcctcc aatggtgctt ggctggactc catcacttgc     6300

ctcctgagtg agcttcccca gcttagtctc cccagtggac agcagatagc acgaccccca     6360

ggcacctttc tcttgatgga ggtggctgac acaacaggca tatcccccac agtggtaggc     6420

tgttgtgccc tagtctggtg tggtggagag cagacttggc agtgtatact tagtgccctg     6480

atggcatccc ttccttatga gtaccgcctg cagcaccgga cagtcgctga gctcaaccac     6540

atggctgagg ttctggtgcc tgcaacattg cgattcctca cctgccaagg tgtcagctct     6600

ctgctgcagg tacacgggca gcaggctgtt tgtgcaggtg tggcagaagt taccagcatg     6660

gcacgcatct tgcatagtct gcttgacctc caccttcgcc taaaggagga gaaggcccct     6720

ggcccagagg acctcagcta tagtgatcct gtggcccaaa gcttcaggtc ttcaaaaagc     6780

agctttctaa accggtccca ggttgacagt gacgatgtgc cagataagtg cagggaacac     6840

ttgctggctg tcagcagttt tctttttgcc ttgatctggg gctttggagc ccaccttccc     6900

tccaggttct ggcccatctt tgataccttc ataagggatt ctattagtcg cctctccaac     6960

taccctgagc caccaccctc agccttggtg tttgatctac atgtaagccc tgaagatgga     7020

acactggtcc ccttcactgg ccaatacctg agcagccaca tcaaaggaac tttgggcacc     7080

tttcaccctt ctatccagac tgaacggctc ttgtatgtgg tggacctgct tctgtcaggg     7140

ggacagccag tgttgctggc tggagaggca gcaacaggga agtcagcctt tgtggaggtg     7200

ctggtagagc cacatcaccc ttacatatac agccccatcc accctgcctt cagttcctcc     7260

cacctccgtc tcctgctgag cagaggaatc cagggccaaa cacaagccag cccacagcct     7320

gggcatcacc aggattctaa accctccctc ctcttcttgc tggaggacct gcacctagcc     7380

acttctgacc cagagaagag ctgccagcca gtgttggaga ctctgcgcca ggccatggat     7440

ggcactgtgt atgcccacag caccttggaa ctgcagacgc tgcagcctac agtcaacttc     7500

cttgccactg tcacagtgcc aggatactgt gagcgcccac tgtgtccacg cctctttcga     7560

ctcttcacag tcctggccct ggaaagcatg acccaggcca ccctgctgga aagacatgtg     7620

cctatcattc aggcttggct tgagcgtttc ccttctgtgg aacgggagcg tgctctggca     7680

cgaggtctgg ttagggcctc agtagaggcc tgggaggctg tgtgcaattg cttcatgcct     7740

tcacccctcc acccacacta ccacttctcc ctacactctg tgagccacct actgagcagc     7800

ctgcagctgc tgcccaacag aacaggctcc cgaggttttg tggactatcc caaccaccag     7860

gagcacttgc gccgggtgtc aggcctgcga ggcacttgtc tgaccgttat gatggccaca     7920

cgcaatgtgg tgcgtctttg gttgcatgag gcacagagaa ccttttgcga ccggctggac     7980

agccccaggg aacgctccta ctgtgccaag ctgctcctag tagtagctca aagtgtcttc     8040

tgctgtgggc cagggcccca gcacctgggc aaggaccatc aggagagtga ggaggaggag     8100

gaggaggaga gggtgcccga agtagaatct gaaggggagt tggcccagtg ggaggacttc     8160

agcaacagca atagtgaaac agaggaggaa gaggaacctt atggccttca ggtcgccaga     8220

gtctcaaact ccagagatcc aagtctaaca ccatccatag gaccagtaag cagggggatg     8280

aaggaaagca taagtcacaa gataaggcaa gagaaaggca caagggcatc caactatagg     8340

ctccaggtaa ggagatcatt caagacttgg tggcagaaga aaccccagat ggacctgatc     8400

tcacccttgt tgttaccagt gttactacta catccccagg aaaagccctc agacctggtc     8460

ttcagtcagg agctgatact ggggcctaac tctgagaccc ccaacttgta cctggaacga     8520

cagtgggaga agctagagga gcagttggcc acctcagctg ctcaactgaa gttgagcccc     8580

cacctggccc ggtgtcattc catggcccag cacgtggccc gcctggtccg ggtgctggcc     8640

aggccccggc agcatggcct gctgctctcg ggggctctgg gtactgggcg ccacactgcc     8700

atcactctgg cttctagcat ttgtcaggcc catttctttc atctaccatc tgggtcagag     8760

gaggccattc tccaatgtct acgagatgcc agctggcatg ctggcatgtt aagccagcca     8820

gtggctctgt tggtacccag tggtgtggat ctcactacac ttcatcgcct cctggccctg     8880

gcaacctcag gcagtttccc tggccagtac acagaagcag atttggaccg cattggagaa     8940

cacctcccca gggagaacct tggtgtcaaa cagaacatca agaaggaaat ggtgttgcag     9000

aggttccacc agcaagtgtg cagccacctt cacctgttct tcctgattgg agataaacag     9060

gcccacaagc agctgccctc cacccttttc ctgaggctcc ttcaactggc cactgccagc     9120

attgaccgct atgaaccctg ggaccaagct gccctggcca aggtggccca gcatcacctg     9180

gagggtgctc agagtgtgcc ccttgatgac ggctcctgga agtacccaga cctccaggcc     9240

tcaattccca gtgtggccaa agccatggct cttatccacc tttcggccac ccactaccat     9300

gagcacctgt gccctgcatt gccactcgtc acccccaaga ccttcctaga cttcctggac     9360

actttcctga tgctgcagca acagacaatc ctgaagatta agaacaaggc ccagcgggtc     9420

cagaatgcct tggagaatct gagaatgctg attaaggagc acggtaccca tgccaatctg     9480

atctttgact tggaacagca gctgaaagac tccggcaaga gtctcagcat gtttcagcag     9540

cagctagagc aaagcaagct cctatacaag cagcagctgg aagagtgtcg gcatcaagag     9600

aacctcattg agaacctggc caggcaacgg gatgccctgc aagctcagcg agaggctttc     9660

ctggagcaga tgagcaaggc atttctggag cctctgagcc agctgcaggt ggctgacttt     9720

gaggagatac ggagctatcg agcaccacca gaatctgtgg tccgggtaac tgatgcaatg     9780

tgtgacttgt tccaccatga aacaggctgg gccagtgcca aacagctgtt atgcactgag     9840

gatttttatc aggagctggt gttcttcccc aaggagaaga taacagactc agagctgata     9900

aagttacatc taattctgaa ggctccaggt atggacgatg cagccctgcg ggcagtgagc     9960

cgacctgcag ccagcctggc agcctggctc tgggctgttc tgcactatgg gctggcgcat    10020

tgccggggac tgcccacgga cctgctgctg cagcaagtgg aggcaacact cactcgggag    10080

caggcccgcc tgggctacta ccagtttcag gcccaggaga ccctggagca taatttggcc    10140

ctggctaaga tggtggagga tgcccaagct tcccacaact gcgtggcaaa gaccctcagt    10200

caagcacagt gtgggcagta tcacaaatgg cccatgaagg ctgcactgct cacgcctatg    10260

cgtgcctgga ctacacagct ccagaagctg aagggacgct gcatgactgt gtttggagat    10320

accctcctat gttcagctgc catcatctac ctgggtccct tcccaccatt gcggcgccaa    10380

gagctactgg acgagtggtt agctctgtgt aggggctttc aggaggctct gggcccagat    10440

gatgtggcac aggcactgaa gcggaagcaa aaatctgtca gcataccacc aaagaacccc    10500

ctgctggcta cacactctcc cttcagtatt ctgtccttgc tgagctctga atcggagcag    10560

taccagtggg atggaaacct gaagccacag gcaaagtcgg cccacctggc aggcttgctt    10620

ctgcgaagcc ccacacacta cagtagttgc cgttggcctc tgctgcttga ccccagcaac    10680

gaggccctca tctggttgga cccgctgcct ctggaagaga atcgatcttt tgcgccagcc    10740

ctcactgagg gtagagggaa aggcctcatg agaaatcaaa agagagagag taaaacggac    10800

atgaaagagg aagatgatga gagtgaagag agtaatgagg ctgaggacca gacaaaagag    10860

cagaaggcag aggaaagaaa aaatgagcag gagaaagagc aagaggaaaa tgaagagaaa    10920

gaggaggaga agacagagag ccaggggtca aagccagcct atgagactca gcttccatcc    10980

cttccctacc ttagtgttct ttcaggtgct gacccagagc tgggttctca gctccaggag    11040

gcagctgctt gtggcctgcc tgtgttactg accaatgtgg agctgggtct agggtgcgaa    11100

gaactgcaat ggctgctgca acgggagcag ctgagtccac cccaggtgca gcctggcttc    11160

tgtctgtatc tcagcaccac cctctccctc tgtgccatgg aaaaagtgct aggttgtgaa    11220

ctgctaaagg ggctgaatgt gttggatctg ggcctgaaca tggaaatact ggaagaacag    11280

atgctgcatg aaatcttgtg cagagagtat cctgaactcg agacccgctg gcaggaccta    11340

aagatcagag ccctagatac ctgcaaggct gtggaggctg ctgaggagcg gctgctgacg    11400

atgctgctgt tccagaatcc gaagcgtcag aagccagcca agtttctgcg gaacatagtg    11460

agggcccaag gaaagctatg ccagctgcgt gctcattgtg aagagttaga agggcagaaa    11520

ctacaggaga tggtattgtg ggcaccctat cgacctgtgg tttggcatgg aatggccatg    11580

gtaaaggccc taagccaact gcagaacctg ctgccacttt tctgtatgag cccagagaac    11640

tggctggcag tcactaagca ggctctggac agcatgaagc cacgtgagat taatcacggg    11700

gaggacctgg ccagccatct actgcaattg agagcacacc tgacccgcca gctgctgggc    11760

agcaccgtga ctgcactggg ccttacccaa gtacccttgg tgggtgcatt gggcgctttg    11820

gctctgctgc aagcaacagg gaaagcatca gagctggaaa gactggcact ctggcctgga    11880

ctagcagcct ctcccagcac agtccacagc aagccagtct cagatgtggc tcgaccggcc    11940

tggcttgggc caaaagcctg gcatgaatgt gagatgttag agctgctgcc cccatttgtt    12000

ggcctgtgtg cctccctggc aggccactcc agtgcttggc aggcttacct gtcactgtca    12060

tccacagtgc tgggtcctgc acctgggcca gggcctgagc cactcagcct cctccagaag    12120

ctgatcctgt ggcgcgttct gcgacctgag tgcctggcag gtgccctggc agacttcacc    12180

actagcctcc tgggtcggcc cctggatgaa aacacgtatg ctcccaccat gccctttaaa    12240

catagtcagg ctactcagcc catgctgatc ttgttgccac cgcctggcca cccctcagcc    12300

actctgcatc ctctgactgt catccagaaa ctggctgcca agtatcagca ggggcagaag    12360

caactgcagg tgatagccct gggctctgaa gcctgggacc cagtctcagt tgtggtcagc    12420

actctatccc aggctatgta tgaggggcac tggctggtgc tggacaactg tcatctgatg    12480

ccccattggc cgaaagagct gctacagctc ttgctggaac tgttaggcag agccaaggtg    12540

gttgcagacc tggaatcaga acagctttta gaccaacctg aaagcaggaa tgtaagcact    12600

gttcacagag attttcgtct ttggcttatt gtgcctgcag agtctagtgc ttctttgcca    12660

gctgtgctga ctcagcactc catgcctgtt ttctggaacc agtccctgga gctgggccat    12720

gttttgattg acagtgtgga gctagcccag caagtactct acatgcaacc ccccacccag    12780

gcactacctc tgctcctcct ccatggcctc ctgctacacc ggcagctcta tggaacaagg    12840

ctgcaggcac acagggggcg ctggagtcaa gtgactctaa cccaggttct tcagacccaa    12900

gaccagctgt gggcaagtct tagcaatccc cgtgctgcca tgcaagagct ggctgcttca    12960

gttttctacg ggggtcctct gggggacact gaggacaggg aggccctgat tagcctcaca    13020

caagcctgcc tgagccccag tagtgggagc tgggtccagc cacacacacc tcagtctttg    13080

ctggccacgc tcatgcccct cccagagcta agggagctgg atgcaatggc agagtgcaag    13140

gcccagatgc acctactgcc ctcaccacct gaaccccggc tctgcggact gagtgagggc    13200

ccccaagcct ggctgttgcg acgccagagt cgcgctctct tgagtgcgct gcagcggagt    13260

tcacccgtgt gggttcctga gtctcgaaga ggcgcccagc ttgcggaaag gcgactgcgg    13320

caacgcctag tgcaagtcaa ccggaggctg gagtcactgc aggatctgct gacccacgtg    13380

attcgccaag acgagtccga cgccccgtgg tcagtgctgg ggccaaatgc acggcggcct    13440

ctggagggcg tcttagagac cgaggctcta gaactgagcc agttggtggg cacgctacaa    13500

cgcgaccttg attgcctgtt gcagcagctg aagggcgcac ccccgtgccc ctcccgccgc    13560

tgtgctgcgg tggcccacgc tctctggact ggccgcctac ccttgccttg gcgacctcat    13620

gcgccggccg gtccgcagcc gccctggcac tggctgcgac agttgtcgcg ccgtgggcaa    13680

ctgttggttc gttacttggg cgtgggcgcg gacgcgagca gtgatgtacc agagcgcgtc    13740

ttccacctgt cagcctttcg ccacccgcgc cgcctgctgc tggcattgcg tggggaagct    13800

gccctggacc agaatgtgcc cagctcgaat ttccctggta gccgaggctc ggtctccagt    13860

cagctccagt ataaacgtct ggagatgaac agcaaccctc tgcacttcag ggtggagaat    13920

ggtccaaatc ccacggttcc agagagaggg ctgctgctga tcgggctaca ggtcctacat    13980

gcggagtggg acccaatagc tggagccttg caggacagtc cttccagcca acccagccct    14040

ctgcctcccg tcagcatcag cacacaggcc ccgggcacca gtgacctgcc agccccagcc    14100

gacctgactg tgtactcgtg tcctgtgtac atgggagggc cccttggcac cgctaagctg    14160

cagagcagga acatcgtgat gcatctgcct ttacccacca agctcacccc caacacctgt    14220

gtccaaagga gggtccatgt gtgcagccca cccctgtctt gagcccgtct accaaaataa    14280

agttgtagtg attccatg                                                  14298


<210> 4076
<211> 899
<212> DNA
<213> Homo sapiens

<400> 4076
gaagcgcgtg aggaccggac gggcggcgcc gtggggcctt cccagggctc taggccgcct       60

ttagggtggg ggaggggccg ggcgagggga cgaccgccag cctcgggatt tggggcttgg      120

gtcgtttctc acaagcaacc ggaggcctgc gccgctgccg gcgtctcccg ggtgggagct      180

cagcgcggag gctggggtct cggccgggga cgtgtggggt gtgcccggac cctcccctcc      240

gcatcccgcc ccttaagcag ctttaagggg ccggagccgg cggctatttc tatcccagga      300

aatccccggg ccatctgtga ccaacaaagg cccgagcccc cccacccccg cgagcccaac      360

aacagggccc aacggcccct ggctccgggg tggggggatc gggcctggat cggctgccgg      420

tgcctgccag tgggcagggt taggcttgct gaggggcagg cacaggagtc ctggctgagc      480

tcatggcctg aggctgccta gcggccacgg ggaatggttg caatggcgga ggcagaggca      540

ggggtggcag tggaggtccg tggactgccc cctgccgtgc ccgacgagct gctcactctc      600

tactttgaaa accgccgacg ctctggaggg ggacctgtgt tgagctggca gagactgggc      660

tgtgggggcg tcctcacctt cagagagcct gcagacgccg agagggtctt ggcccaggca      720

gatcacgaac tacatggtgc ccagctgagc ctgcggccag ctccaccacg agcccctgca      780

cgcctgctgc tccaaggact gccccctggc accacgcccc agcgcttgga gcagcatgtc      840

caggccttgc tgcgggcctc ggggctccca gtacagcctt gctgtgcctt ggccagccc       899


<210> 4077
<211> 1264
<212> DNA
<213> Homo sapiens

<400> 4077
ccggcggagc gtcctcgcat ggagcgcgag cccagcgcct cggaggccgc ccccgcggcg       60

gccgcgctct tcgcctgggg tgcaaatagc tatgggcaac ttggcctcgg ccataaggaa      120

gatgtgctgt tgccccagca actgaatgac ttctgtaaac ccaggagtgt caggaggatc      180

acaggaggag ggggccactc tgcagttgtc acagatggag gagacctctt tgtttgtggc      240

ctgaacaaag atgggcaact ggggcttggt cacacagagg atatcccata ttttaccccc      300

tgcaaatccc tctttggctg tcccatccaa caggtggcct gtggctggga ttttacgatt      360

atgctcacag aaaatggtca agttctatca tgtggatcca actcctttgg ccagttagga      420

gttcctcatg gacctcgaag atgtgtggtt ccccaggcca ttgagctcca taaagagaag      480

gttgtttgta ttgctgctgg actgaggcat gcagtagctg ctacagcgag tggcatcgtg      540

ttccagtggg ggactggttt ggcatcatgt ggacgacggt tgtgccctgg gcagactctt      600

ccattgtttt tcacagcaaa ggaaccaagc agagtgacag gtctagagaa ttctaaagca      660

atgtgtgttc ttgctggctc agaccactca gcttcattaa cagatgcagg agaggtgtat      720

gtttggggaa gcaacaagca tgggcaactg gctaatgagg ctgctttcct tcctgtgccc      780

cagaaaatag aagcacattg tttccagaat gaaaaggtca ctgccatctg gagtggatgg      840

acacacctgg ttgctcagac aggtctcttg tggctcagag cataatttgg caataattgg      900

tggagtgtgt tactcttggg gctggaatga gcatggcatg tgcggagatg gcactgaagc      960

caacgtctgg gccccaaagc cggtgcaggc tctgctgtca tcgtcaggac tccttgtggg     1020

ctgtggggct ggccactcct tggccctctg ccagctgcca gctcaccctg cattggtcca     1080

ggaccccaag gtcacctacc tttccccaga tgccatcgag gacactgaat ctcagaaagc     1140

catggacaaa gagagaaact ggaaggaaag acaatcagaa acttcaaccc aaagccaatc     1200

tgactggtcc agaaatgggg gactgtgata gagaatcttt aataaagtgg cttttcccac     1260

caaa                                                                  1264


<210> 4078
<211> 560
<212> DNA
<213> Homo sapiens

<400> 4078
aaactgtcat ggcgctggtg gcagtgtagc agtgaggaca accagaggtc actctcatca       60

ccatcttagt tttgggtctt gctctgtcac ccaggctgga gtgccatggc atcatcatag      120

ctcactatgg ccttgatcct cctgccttag cctcccaagc agctggtatt acagaccacg      180

gtgtgaacac atgaacagaa gacgaaaatt tcttctagcc tcagtacttg ctctccagaa      240

ttcaagtttt atatatccat catgtcagaa gtgcttctct aggataatcc tggtctccaa      300

aaggtctaat tgtccaaaat gtggctctac tggtgaatct ggaaatgcca attacagata      360

caaactttcc ttaaaagttg cagaatcaaa caaattgttt gttattactg tatttggaag      420

ttgcttagat acattttttg gtcttactgc cactggtttg cacaggtaca ttcaggatcc      480

taataaaatt ccagaaacac tggacaatga tacaactcag aatctattaa ctaaagcagt      540

tgaaacttgc tttgttggac                                                  560


<210> 4079
<211> 818
<212> DNA
<213> Homo sapiens

<400> 4079
ctggctgagt gagatggcag ctggcttggc aaggggacag cacctttgtc accacattat       60

gtccctgtac cctacatgct gcgcctatac ccaggaccga tggtaactga ggcggagggg      120

aaaggagggc ctgagatggc aagtctgtcc tcctcggtgg ttcctgtgtc cttcatttcc      180

actctgcgag agtctgtgct ggaccctgga gttggtggag aaggagccag tgacaagcag      240

aggagcaaac tgtctttatc acactccatg atcccagctg ctaaaatcca cactgagctc      300

tgcttaccag ccttcttctc tcctgctgga acccagagga ggttccagca gcctcagcac      360

cacctgacac tgtctatcat ccacactgca gcaaggtgat tctgccaaaa catatctcct      420

taaaagccaa ctggagcttc tcatcagcat caatgtgaag ccaaaaatcc ttaggaggac      480

agagggagtc cctcacaacc tagactggtc cccttccctc cagctgcctc aactgtccac      540

aggactctct tcccacctgc ggccacactg tgcaacctgg aatttcccca cctgggcgga      600

ctcatcacgt catcaccaat tggatgcatc ttctgctctg tgcagctggt gaaatctttc      660

tcaacccttg agatgcagcc caatcttctc ctaacatctg gattcctctc tgtcactgca      720

ttccctcctg tcatcctgcc tttgttttct tgccctcctt tctctcccgg gtgataggca      780

ttaactaaaa ttaaataaaa attcagatca tccttgca                              818


<210> 4080
<211> 2351
<212> DNA
<213> Homo sapiens

<400> 4080
gggaagcgac cggctgctgg gcttaaggcg ggagtgaccg cttaaccagt gagggaagca       60

ctgaagagcg ccagtcgacg tgggtgcgac aactcgcgga gtcttaggag caaaacgtct      120

ggggcctgcg agccaggacc cttctgaagc cttaggtgtc tatcggcgac gtgtacggtc      180

actgcagctc cggagcgcgg aaccctcagc caggaggcgc ggctggtcgg tcccaggtcc      240

cggcctccgt aatgagagcc cggaaccact ctttgtgccg cagcttcgca gattcctata      300

ggcaatggaa actgatctca attcccagga cagaaaggac ctggacaagt ttattaaatt      360

ttttgccctc aagactgtcc aagtgattgt ccaggctcgg cttggtgaaa agatttgcac      420

tcgttcatca tcttctccaa cgggttcaga ttggttcaac ttagcaatca aagacatccc      480

agaggttaca catgaagcaa agaaggcact ggcaggacag ctgcctgcag tcgggaggtc      540

catgtgtgtg gagatttcac ttaagacttc tgagggagat tccatggagc tggaaatatg      600

gtgtcttgaa atgaatgaaa agtgtgataa agaaatcaaa gtttcctaca cggtgtacaa      660

cagactgtca ttgctgctga agtcccttct tgctataact agggtgacac cagcctatag      720

gctctccagg aaacaagggc atgaatatgt catattatac aggatatatt ttggagaagt      780

tcagctgagt ggcttaggag aaggcttcca gacagttcgt gttgggacag tgggcacccc      840

tgtgggcacc atcactcttt cttgtgctta cagaattaac ttggcattca tgtctaccag      900

gcaatttgag aggaccccac ctatcatggg gattattatt gatcactttg tggaccgtcc      960

ctatcccagc tcctctccca tgcacccctg caattacaga actgctggtg aggacactgg     1020

agtaatatac ccgtctgtag aagactctca agaagtgtgt accacctctt tttccacctc     1080

cccaccatcc cagtgtgtgt ttactgtcac aaaggcacat tttcagaccc ctactcctgt     1140

ggtgacggac accctgaggg tccccatggc aggactggcc ttttcccatc aactctcaag     1200

ctctcgcctt tcctatcagc ctgctgccct gggcgttgga tcagctgacc tggcttatcc     1260

agtagtgttt gctgctggct taaatgctac acaccctcac cagctgatgg ttcctgggaa     1320

ggaaggtggg gtaccccttg ctcccaacca gcctgtccat ggtacccagg ctgaccagga     1380

gagactggca acctgcaccc cttctgacag aacccactgt gctgccacac cctccagtag     1440

tgaggatact gaaaccgtat caaacagcag tgagggacgg gcctcccctc acgatgtctt     1500

ggagaccatc tttgtccgaa aagtgggggc ttttgtcaac aaacccatta accaggtgac     1560

cctgacgagt ttggatatac cctttgccat gtttgctccc aagaatttgg agctggagga     1620

taccgatcca atggtgaatc ctccagattc cccagagact gaatctcctc tccagggcag     1680

cctgcactca gatggctcca gcgggggcag cagtggcaat acccatgatg actttgttat     1740

gatagacttt aaaccagctt tttctaaaga tgacattctt ccgatggacc tggggacctt     1800

ctatcgggag tttcagaacc cacctcagct gagcagcctc tccatagata ttggagcaca     1860

gtccatggct gaagacttgg actcattacc agagaagctg gctgtgcatg agaagaatgt     1920

ccgcgagttt gatgcctttg tggaaaccct gcagtaaaag tatccttgag tcccagcagc     1980

accccctttt tgtggcccca gggcataagc agcctcccat gcatcagctg ctcccacccc     2040

tcatcctgct ctgagccagg tggaagggag gctggcttct cccatgggga cccagaagtc     2100

cctactcttg gacctcctgg agactccgtg gcggcagtca agcccagtgc ccagttggag     2160

aagactcacg tgctggcctt ggagatggga agaaccttcg tacgaaaaag ccctcagcag     2220

ggccatctgt gtgccctgcc catcaccaac tgcttcccaa gggtgtcatc ctgttcctcc     2280

tgctgccggc ctcctgcctg ggcctgcctt gcagctggcc ccttccctgc ctgctgtcac     2340

catccactgt t                                                          2351


<210> 4081
<211> 4404
<212> DNA
<213> Homo sapiens

<400> 4081
acacacacac acacacacac acacacacac acctgagatg gggtagatca ttgtattttt       60

gtgtctacca gcaagaaaag gaaggaaaaa ctaagggctc tgtgtatgaa tgacaaggat      120

accttcagcc agctcattct ggatgaatga atgattacac taagtgtcct ccacattcct      180

ctgtgggctc acttcatgga ctcactttgc gtgcttgtta aatgtgctgt gttgctccca      240

agaccatgta aagcctactg accactaacc tccctcacag cagaaactag acgtcaggtt      300

aaaatgggca actccgacag tcagtacacc cttcaaggat ctaaaaatca tagcaatact      360

attactggtg ctaagcaaat tccttgctcc ctgaaaatac gtggcattca tgcaaaagag      420

gaaaagtcat tgcatggatg gggtcacgga agcaacggag caggttacaa gtccaggtcc      480

ctggcccgaa gctgcctttc tcactttaag agtaaccagc cttacgcatc gagactcggt      540

ggccccacat gcaaggtctc cagaggtgtt gcctactcca cgcacaggac aaatgcccca      600

gggaaggatt tccagggcat cagtgctgct ttctcaactg agaatggctt ccactctgtt      660

ggccacgagc tggcagataa ccacatcacc tccagagact gcaacggaca ccttctcaac      720

tgctacggga ggaatgagag cattgcctcc accccaccgg gcgaagaccg caagagcccc      780

cgagtgctca tcaaaacgct ggggaagctg gatgggtgtt taagggtcga gttccacaat      840

ggtggcaacc ccagcaaagt gcctgcagag gactgcagtg agccggtgca gctgctgagg      900

tactcaccta ccttagcatc ggaaacctcc cctgtgcctg aagccaggag ggggtccagc      960

gccgattccc tgcccagcca tcgcccctct cccacggact ctcgcctgcg gtccagcaaa     1020

ggcagctccc tgagttctga gtcatcctgg tacgactccc cttggggcaa tgctggagag     1080

ctgagcgagg ctgagggctc cttcctggcc cccggcatgc ctgaccccag tctccatgcc     1140

agcttcccac ctggcgatgc caaaaagcct ttcaaccaaa gctcttccct ctcctccctc     1200

cgggaactgt acaaagatgc caacctgggg agcctctccc cctcaggtat ccgcctttct     1260

gatgaataca tgggcacgca tgccagcctg agcaaccgtg tctcttttgc ttccgacatt     1320

gatgtgccct ccagagtggc acacggggac cccatccagt acagttcctt cactctcccc     1380

tgtcggaagc ccaaagcctt tgttgaggat actgcgaaga aggactccct caaagccagg     1440

atgcgacgga tcagtgactg gacgggaagc ctctcaagga agaaaaggaa actccaggag     1500

ccgaggtcca aggagggcag tgactacttt gacagtcgct ctgatggact gaatacagat     1560

gtgcagggat cctcccaggc atctgctttt ctgtggtcag ggggctctac tcagatcctg     1620

tctcagagaa gtgaatccac acatgcgatt ggcagcgatc ccctccggca gaacatttat     1680

gagaatttca tgcgagagtt ggaaatgagc aggaccaaca ctgagaacat agaaacatct     1740

acagaaaccg ccgagtccag cagcgagtca ctcagctctc tggaacagct ggatctgctc     1800

tttgagaagg aacagggggt ggtccggaag gccgggtggc tcttcttcaa gcccctggtc     1860

actgtgcaga aggaaaggaa gcttgagctg gtggcacgaa ggaaatggaa acagtactgg     1920

gtaacgctga aaggatgcac gctgctgttt tatgagacct atgggaagaa ttccatggat     1980

cagagcagtg cccctcggtg tgctctgttt gcagaagaca gcatagtgca gtctgttcca     2040

gagcatccca agaaagaaaa tgtgttctgc ctcagcaact cctttggaga tgtctacctt     2100

ttccaggcca ccagccagac agatctagaa aactgggtca ctgctgtaca ctctgcttgt     2160

gcatcccttt ttgcaaagaa gcatgggaaa gaggacacgc tgcggctgct gaagaaccag     2220

accaaaaacc tgcttcagaa gatagacatg gacagcaaga tgaagaagat ggcagagctg     2280

cagctgtccg tggtgagcga cccaaagaac aggaaagcca tagagaacca gatccagcaa     2340

tgggagcaga atcttgagaa atttcacatg gatctgttca ggatgcgctg ctatctggcc     2400

agcctacaag gtggggagtt accgaaccca aagagtctcc ttgcagccgc cagccgcccc     2460

tccaagctgg ccctcggcag gctgggcatc ttgtctgttt cctctttcca tgctctggta     2520

tgttctagag atgactctgc tctccggaaa aggacactgt cactgaccca gcgagggaga     2580

aacaagaagg gaatattttc ttcgttaaaa gggctggaca cactggccag aaaaggcaag     2640

gagaagagac cttctataac tcaggtcgat gaacttctgc atatatatgg ttcaacagta     2700

gacggtgttc cccgagacaa tgcatgggaa atccagactt atgtccactt tcaggacaat     2760

cacggagtta ctgtagggat caagccagag cacagagtag aagatatttt gactttggca     2820

tgcaagatga ggcagttgga acccagccat tatggcctac agcttcgaaa attagtagat     2880

gacaatgttg agtattgcat ccctgcacca tatgaatata tgcaacaaca ggtttatgat     2940

gaaatagaag tctttccact aaatgtttat gacgtgcagc tcacgaagac tgggagtgtg     3000

tgtgactttg ggtttgcagt tacagcgcag gtggatgagc gtcagcatct cagccggata     3060

tttataagcg acgttcttcc cgatggcctg gcgtatgggg aagggctgag aaagggcaat     3120

gagatcatga ccttaaatgg ggaagctgtg tctgatcttg accttaagca gatggaggcc     3180

ctgttttctg agaagagcgt cggactcact ctgattgccc ggcctccgga cacaaaagca     3240

accctgtgta catcctggtc agacagtgac ctgttctcca gggaccagaa gagtctgctg     3300

ccccctccta accagtccca actgctggag gaattcctgg ataactttaa aaagaataca     3360

gccaatgatt tcagcaacgt ccctgatatc acaacaggtc tgaaaaggag tcagacagat     3420

ggcactctgg atcaggtttc ccacagggag aaaatggagc agacattcag gagtgctgag     3480

cagatcactg cactgtgcag gagttttaac gacagtcagg ccaacggcat ggaaggaccg     3540

cgggagaatc aggatcctcc tccgaggtct ctggcccgcc acctgtctga tgcagaccgc     3600

ctccgcaaag tcatccagga gcttgtggac acagagaagt cctacgtgaa ggatttgagc     3660

tgcctctttg aattatactt ggagccactt cagaatgaga cctttcttac ccaagatgag     3720

atggagtcac tttttggaag tttgccagag atgcttgagt ttcagaaggt gtttctggag     3780

accctggagg atgggatttc agcatcatct gactttaaca ccctagaaac cccctcacag     3840

tttagaaaat tactgttttc ccttggaggc tctttccttt attacgcgga ccactttaaa     3900

ctgtacagtg gattctgtgc taaccatatc aaagtacaga aggttctgga gcgagctaaa     3960

actgacaaag ccttcaaggc ttttctggac gcccggaacc ccaccaagca gcattcctcc     4020

acgctggagt cctacctcat caagccggtt cagagagtgc tcaagtaccc gctgctgctc     4080

aaggagctgg tgtccctgac ggaccaggag agcgaggagc actaccacct gacggaagca     4140

ctaaaggcaa tggagaaagt agcgagccac atcaatgaga tgcagaagat ctatgaggat     4200

tatgggaccg tgtttgacca gctagtagct gagcagagcg gaacagagaa ggaggtaaca     4260

gaactttcga tgggagagct tctgatgcac tctacggttt cctggttgaa tccatttctg     4320

tctctaggaa aagctagaaa ggaccttgag ctcacagtat ttgtttttaa gagagccgtc     4380

atactggttt ataaagaaaa ctgc                                            4404


<210> 4082
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4082
actagctagg ccgtgtggcc accctttggc acccgcaccg gctcagacct gctcaggact       60

cagccagggc acacagtttg tgttcttacg tgcatccatc tgtctgtctg tgtgcgtctc      120

tgtggaggac tgaggttttc aagtgaaaga gagtgaagac atagtccaga gagggaagtg      180

taaagctaca ggctgaacat aacttctttt tttcaaagtt ccctgtgttg tgaactgagc      240

ttgggtgaag tgaaatcttt gaggaagcta aagctgtgtg tatttgtgga tcagacaagt      300

gcagcaagtt aatatcattg gcttctgaag gggagagtga ggtgatggct gcgtttaagt      360

tggatttcct tccagaaatg atggtggatc attgctcttt gaattccagt cccgttatgt      420

ttcagcagaa atcaaggtag acgaagtaac ctcttgtcct gaattttcat agttgctcat      480

tcttaataat ggcagcagaa gcaacaatga gagtaactac ctcctcagct caaagaaaat      540

gaacggcacc ctggaccacc cagaccaacc agatcttgat g                          581


<210> 4083
<211> 685
<212> DNA
<213> Homo sapiens

<400> 4083
gggggcgggg gcggcaggcc gcgcggcgca gcgggtcaga ggcgctcctg ggctcgggcc       60

ggggactcac cggtggccgg gcgccgcagg ccgggttagg cttgctgagg ggcaggcaca      120

ggagtcctgg ctgagctcat ggcctgaggc tgcctagcgg ccacggggaa tggttgcaat      180

ggcggaggca gaggcagggg tggcagtgga ggtccgtgga ctgccccctg ccgtgcccga      240

cgagctgctc actctctact ttgaaaaccg ccgacgctct ggagggggac ctgtgttgag      300

ctggcagaga ctgggctgtg ggggcgtcct caccttcaga gagcctgcag acgccgagag      360

ggtcttggcc caggcagatc acgaactaca tggtgcccag ctgagcctgc ggccagctcc      420

accacgagcc cctgcacgcc tgctgctcca aggactgccc cctggcacca cgccccagcg      480

cttggagcag catgtccagg ccttgctgcg ggcctcgggg ctcccagtac agccttgctg      540

tgccttggcc agcccccggc cagaccgggc tctggtccag ttgcccaagc ccctttctga      600

ggcagatgtc cgtgtcctgg aggagcaggc ccagaatctg ggcctggagg ggaccttggt      660

gtccctggcc cgggttcccc aggcc                                            685


<210> 4084
<211> 538
<212> DNA
<213> Homo sapiens

<400> 4084
acgtccgcca ttttgggcgc ttcgctgatg gtgtcggtga gcgcgtttcc cgcctgagcg       60

caactagcgg cgggtcgtgg gcacctccag ataagaaaac aagctcagag agatgtggtg      120

acttgctcaa atagtgacag aacttcctcg gccatatgga ggggtcatat aatacccttg      180

tgtcttcagt ttgaggtacc tcccataatt ttaaggggct cagaaggaaa gaaaacatct      240

cccaggacca gatgtggagt agatgggagt tggagagaag ctgaagccca ggcccagcaa      300

caggctgggg gcccaggtgc ttcgggggtc ccagccatta acagagcttc gtgcaggaga      360

gcttgtttca tatccatatc ccactgtatt cctgctaatc tgctaatgca gtaaattgga      420

ggaaaactgt taccaggata acctgtaatg ggcaaggagc cacaaagaag aaaacatttc      480

ttttaatttt taaacttggt ttgaaagacc agcatgtttt ggaaatttga tcttcact        538


<210> 4085
<211> 589
<212> DNA
<213> Homo sapiens

<400> 4085
gcgcaactcc acctgcttct gggaacccag ggggaagcaa gggaagaccg tgacctttgc       60

cccgggctgt ggggagcccc ggagcctggg cccggagaag cgccagggtt aggcttgctg      120

aggggcaggc acaggagtcc tggctgagct catggcctga ggctgcctag cggccacggg      180

gaatggttgc aatggcggag gcagaggcag gggtggcagt ggaggtccgt ggactgcccc      240

ctgccgtgcc cgacgagctg ctcactctct actttgaaaa ccgccgacgc tctggagggg      300

gacctgtgtt gagctggcag agactgggct gtgggggcgt cctcaccttc agagagcctg      360

cagacgccga gagggtcttg gcccaggcag atcacgaact acatggtgcc cagctgagcc      420

tgcggccagc tccaccacga gcccctgcac gcctgctgct ccaaggactg ccccctggca      480

ccacgcccca gcgcttggag cagcatgtcc aggccttgct gcgggcctcg gggctcccag      540

tacagccttg ctgtgccttg gccagccccc ggccagaccg ggctctggt                  589


<210> 4086
<211> 5844
<212> DNA
<213> Homo sapiens

<400> 4086
gggcggccta tagatccaag agaaggtcct ggacggcctc cactagatgg tagggatcat       60

tttggaagac ctcctgtaga tataagagag aatcttgtga ggccaggtat agatcatctt      120

ggtcgaagag accactttgg ctttaatcca gagaagccct gggggcatag aggagatttt      180

gatgagagag agcatcgggt tctaccggtc tatggtggtc caaaaggctt acatgaagaa      240

agaggtagat ttcggtctgg aaactatcga tttgatccta gaagtggtcc ttggaaccga      300

ggatttggac aagaagttca cagagatttt gatgaccgca gaagaccctg ggagaggcaa      360

agggataggg atgacagaga ttttgatttc tgcagagaaa tgaatggaaa tcgtcttgga      420

cgagacagaa ttcaaaacac ttgggttccc cctcctcatg ctcgggtttt tgattatttt      480

gaaggggcca cttctcaacg aaaaggtgat aatgtgcctc aggttaatgg tgaaaataca      540

gagagacatg ctcagccacc acctatacca gtacagaatg atcctgaact ttatgaaaaa      600

ctgacatctt caaatgaaat aaacaaggag aagagtgaca cagttgctga tatagaaagt      660

gaaccagtgg tagaaagcac agaaactgag gggacaccac taacctccct cacagcagaa      720

actagacgtc aggttaaaat gggcaactcc gacagtcagt acacccttca aggatctaaa      780

aatcatagca atactattac tggtgctaag caaattcctt gctccctgaa aatacgtggc      840

attcatgcaa aagaggaaaa gtcattgcat ggatggggtc acggaagcaa cggagcaggt      900

tacaagtcca ggtccctggc ccgaagctgc ctttctcact ttaagagtaa ccagccttac      960

gcatcgagac tcggtggccc cacatgcaag gtctccagag gtgttgccta ctccacgcac     1020

aggacaaatg ccccagggaa ggatttccag ggcatcagtg ctgctttctc aactgagaat     1080

ggcttccact ctgttggcca cgagctggca gataaccaca tcacctccag agactgcaac     1140

ggacaccttc tcaactgcta cgggaggaat gagagcattg cctccacccc accgggcgaa     1200

gaccgcaaga gcccccgagt gctcatcaaa acgctgggga agctggatgg gtgtttaagg     1260

gtcgagttcc acaatggtgg caaccccagc aaagtgcctg cagaggactg cagtgagccg     1320

gtgcagctgc tgaggtactc acctacctta gcatcggaaa cctcccctgt gcctgaagcc     1380

aggagggggt ccagcgccga ttccctgccc agccatcgcc cctctcccac ggactctcgc     1440

ctgcggtcca gcaaaggcag ctccctgagt tctgagtcat cctggtacga ctccccttgg     1500

ggcaatgctg gagagctgag cgaggctgag ggctccttcc tggcccccgg catgcctgac     1560

cccagtctcc atgccagctt cccacctggc gatgccaaaa agcctttcaa ccaaagctct     1620

tccctctcct ccctccggga actgtacaaa gatgccaacc tggggagcct ctccccctca     1680

ggtatccgcc tttctgatga atacatgggc acgcatgcca gcctgagcaa ccgtgtctct     1740

tttgcttccg acattgatgt gccctccaga gtggcacacg gggaccccat ccagtacagt     1800

tccttcactc tcccctgtcg gaagcccaaa gcctttgttg aggatactgc gaagaaggac     1860

tccctcaaag ccaggatgcg acggatcagt gactggacgg gaagcctctc aaggaagaaa     1920

aggaaactcc aggagccgag gtccaaggag ggcagtgact actttgacag tcgctctgat     1980

ggactgaata cagatgtgca gggatcctcc caggcatctg cttttctgtg gtcagggggc     2040

tctactcaga tcctgtctca gagaagtgaa tccacacatg cgattggcag cgatcccctc     2100

cggcagaaca tttatgagaa tttcatgcga gagttggaaa tgagcaggac caacactgag     2160

aacatagaaa catctacaga aaccgccgag tccagcagcg agtcactcag ctctctggaa     2220

cagctggatc tgctctttga gaaggaacag ggggtggtcc ggaaggccgg gtggctcttc     2280

ttcaagcccc tggtcactgt gcagaaggaa aggaagcttg agctggtggc acgaaggaaa     2340

tggaaacagt actgggtaac gctgaaagga tgcacgctgc tgttttatga gacctatggg     2400

aagaattcca tggatcagag cagtgcccct cggtgtgctc tgtttgcaga agacagcata     2460

gtgcagtctg ttccagagca tcccaagaaa gaaaatgtgt tctgcctcag caactccttt     2520

ggagatgtct accttttcca ggccaccagc cagacagatc tagaaaactg ggtcactgct     2580

gtacactctg cttgtgcatc cctttttgca aagaagcatg ggaaagagga cacgctgcgg     2640

ctgctgaaga accagaccaa aaacctgctt cagaagatag acatggacag caagatgaag     2700

aagatggcag agctgcagct gtccgtggtg agcgacccaa agaacaggaa agccatagag     2760

aaccagatcc agcaatggga gcagaatctt gagaaatttc acatggatct gttcaggatg     2820

cgctgctatc tggccagcct acaaggtggg gagttaccga acccaaagag tctccttgca     2880

gccgccagcc gcccctccaa gctggccctc ggcaggctgg gcatcttgtc tgtttcctct     2940

ttccatgctc tggtatgttc tagagatgac tctgctctcc ggaaaaggac actgtcactg     3000

acccagcgag ggagaaacaa gaagggaata ttttcttcgt taaaagggct ggacacactg     3060

gccagaaaag gcaaggagaa gagaccttct ataactcagg tcgatgaact tctgcatata     3120

tatggttcaa cagtagacgg tgttccccga gacaatgcat gggaaatcca gacttatgtc     3180

cactttcagg acaatcacgg agttactgta gggatcaagc cagagcacag agtagaagat     3240

attttgactt tggcatgcaa gatgaggcag ttggaaccca gccattatgg cctacagctt     3300

cgaaaattag tagatgacaa tgttgagtat tgcatccctg caccatatga atatatgcaa     3360

caacaggttt atgatgaaat agaagtcttt ccactaaatg tttatgacgt gcagctcacg     3420

aagactggga gtgtgtgtga ctttgggttt gcagttacag cgcaggtgga tgagcgtcag     3480

catctcagcc ggatatttat aagcgacgtt cttcccgatg gcctggcgta tggggaaggg     3540

ctgagaaagg gcaatgagat catgacctta aatggggaag ctgtgtctga tcttgacctt     3600

aagcagatgg aggccctgtt ttctgagaag agcgtcggac tcactctgat tgcccggcct     3660

ccggacacaa aagcaaccct gtgtacatcc tggtcagaca gtgacctgtt ctccagggac     3720

cagaagagtc tgctgccccc tcctaaccag tcccaactgc tggaggaatt cctggataac     3780

tttaaaaaga atacagccaa tgatttcagc aacgtccctg atatcacaac aggtctgaaa     3840

aggagtcaga cagatggcac tctggatcag gtttcccaca gggagaaaat ggagcagaca     3900

ttcaggagtg ctgagcagat cactgcactg tgcaggagtt ttaacgacag tcaggccaac     3960

ggcatggaag gaccgcggga gaatcaggat cctcctccga ggtctctggc ccgccacctg     4020

tctgatgcag accgcctccg caaagtcatc caggagcttg tggacacaga gaagtcctac     4080

gtgaaggatt tgagctgcct ctttgaatta tacttggagc cacttcagaa tgagaccttt     4140

cttacccaag atgagatgga gtcacttttt ggaagtttgc cagagatgct tgagtttcag     4200

aaggtgtttc tggagaccct ggaggatggg atttcagcat catctgactt taacacccta     4260

gaaaccccct cacagtttag aaaattactg ttttcccttg gaggctcttt cctttattac     4320

gcggaccact ttaaactgta cagtggattc tgtgctaacc atatcaaagt acagaaggtt     4380

ctggagcgag ctaaaactga caaagccttc aaggcttttc tggacgcccg gaaccccacc     4440

aagcagcatt cctccacgct ggagtcctac ctcatcaagc cggttcagag agtgctcaag     4500

tacccgctgc tgctcaagga gctggtgtcc ctgacggacc aggagagcga ggagcactac     4560

cacctgacgg aagcactaaa ggcaatggag aaagtagcga gccacatcaa tgagatgcag     4620

aagatctatg aggattatgg gaccgtgttt gaccagctag tagctgagca gagcggaaca     4680

gagaaggagg taacagaact ttcgatggga gagcttctga tgcactctac ggtttcctgg     4740

ttgaatccat ttctgtctct aggaaaagct agaaaggacc ttgagctcac agtatttgtt     4800

tttaagagag ccgtcatact ggtttataaa gaaaactgca aactgaaaaa gaaattgccc     4860

tcgaattccc ggcctgcaca caactctact gacttggacc catttaaatt ccgctggttg     4920

atccccatct ccgcgcttca agtcagactg gggaatccag cagggacaga aaataattcc     4980

atatgggaac tgatccatac gaagtcagaa atagaaggac ggccagaaac catctttcag     5040

ttgtgttgca gtgacagtga aagcaaaacc aacattgtta aggtgattcg ttctattctg     5100

agggagaact tcaggcgtca cataaagtgt gaattaccac tggagaaaac gtgtaaggat     5160

cgcctggtac ctcttaagaa ccgagttcct gtttcggcca aattagcttc atccaggtct     5220

ttaaaagtcc tgaagaattc ctccagcaac gagtggaccg gtgagactgg caagggaacc     5280

ttgctggact ctgacgaggg cagcttgagc agcggcaccc agagcagcgg ctgccccacg     5340

gctgagggca ggcaggactc caagagcact tctcccggga aatacccaca ccccggcttg     5400

gcagattttg ccgacaatct catcaaagag agtgacatcc tgagcgatga agatgatgac     5460

caccgtcaga ctgtgaagca gggcagccct actaaagaca tcgaaattca gttccagaga     5520

ctgaggattt ccgaggaccc agacgttcac cccgaggctg agcagcagcc tggcccggag     5580

tcgggtgagg gtcagaaagg aggagagcag cccaaactgg tccgggggca cttctgcccc     5640

attaaacgaa aagccaacag caccaagagg gacagaggaa ctttgctcaa ggcgcagatc     5700

cgtcaccagt cccttgacag tcagtctgaa aatgccacca tcgacctaaa ttctgttcta     5760

gagcgagaat tcagtgtcca gagtttaaca tctgttgtca gtgaggagtg tttttatgaa     5820

acagagagcc acggaaaatc atag                                            5844


<210> 4087
<211> 547
<212> DNA
<213> Homo sapiens

<400> 4087
agtgaagcct gcccacttgt gaagacggag actccccgct ccccggatga gaagcaagtg       60

cgtcagaggg aagcagccca actggttgct gagttgtgga aaataagctg ggggagaaaa      120

aacacttctt ttaaaaatca ggtgtgtctc tagtcctcgt ggttgcctgc cccactccct      180

gccgagacgc ctgccagaaa ggtcacctat cctgaacccc agcaagcctg aaacagctca      240

gccaagcacc ctgcgatgga agctgcagat gcctccagga gcaacgggtc gagcccagaa      300

gccagggatg cccggagccc gtcgggcccc agtggcagcc tggagaatgg caccaaggct      360

gacggcaagg atgccaagac caccaacggg cacggcgggg aggcagctga gggcaagagc      420

ctgggcagcg ccctgaagcc aggggaaggt aggagcgccc tgttcgcggg caatgagtgg      480

cggcgaccca tcatccagtt tgtcgagtcc ggggacgaca agaactccaa ctacttcagc      540

atggact                                                                547


<210> 4088
<211> 549
<212> DNA
<213> Homo sapiens

<400> 4088
gaaattcaga acaggaggac acaagggcag gggaatgctg aggccaaggc cttctcccac       60

cacctgcctc ctgcgggagt gattccacag tgcagaggga gagccatttg gaggtccggc      120

acccgctctg cccatgccta tgcttcaggc tctgtgagaa ggctggactc cttctggaac      180

ttcaggacct tggatgctcc cctcctctgc tcctgcctcc cttcccccag ccctggggtg      240

tgtcagatgt gtgttttctc ctggactcag ctgaagcaag gtcagcccag ctttcaaggg      300

gaggagcttc cacactctag gtgtgtctct agtcctcgtg gttgcctgcc ccactccctg      360

ccgagacgcc tgccagaaag gtcacctatc ctgaacccca gcaagcctga aacagctcag      420

ccaagcaccc tgcgatggaa gctgcagatg cctccaggag caacgggtcg agcccagaag      480

ccagggatgc ccggagcccg tcgggcccca gtggcagcct ggagaatggc accaaggctg      540

acggcaagg                                                              549


<210> 4089
<211> 2603
<212> DNA
<213> Homo sapiens

<400> 4089
agattactat ggaatcggta gggtcctgac cgctggggaa gcaggaaagc gtatcctggg       60

aagaaaggct tggcttggac tccggagaag aatactacat cgagacctgc tggggaattt      120

tattttattt tattattttt ttggtcttgg ttgtactgag ggaggaagaa gaggttgtgt      180

ggcccggtcg aacttgtggc agcctgaagg ccccctcagg cggcgccgcg ggcagccccg      240

cagccggggc ctggtgcagc ctccgcggcc gctgtcaggg aagcgcaggc ggccaatgga      300

acccgggagc ggtcgctgct gctgaggcgg cagtgtcggc agtccaaccg cgactgcccg      360

caccccctcc gcgggggtcc cccagagcct gttcgactgg ctcctgagag agaattcatc      420

aagtccctga tggcgatcgg caagcggctg gccacgctcc ccaccaaaga gcagaaaaca      480

cagaggctga tctcagagct ctccctgctc aaccataagc tccctgcccg agtctggctg      540

cccactgctg gctttgacca ccacgtggtc cgtgtacccc acacacaggc tgttgtcctc      600

aactccaagg acaaggctcc ctacctgatt tatgtggaag tccttgaatg tgaaaacttt      660

gacaccacca gtgtccctgc ccggatcccc gagaaccgaa ttcggagtac gaggtccgta      720

gaaaacttgc ccgaatgtgg tattacccat gagcagcgag ctggcagctt cagcactgtg      780

cccaactatg acaacgatga tgaggcctgg tcggtggatg acataggcga gctgcaagtg      840

gagctccccg aagtgcatac caacagctgt gacaacatct cccagttctc tgtggacagc      900

atcaccagcc aggagagcaa ggagcctgtg ttcattgcag caggggacat ccgccggcgc      960

ctttcggaac agctggctca taccccgaca gccttcaaac gagacccaga agatccttct     1020

gcagttgctc tcaaagagcc ctggcaggag aaagtacggc ggatcagaga gggctccccc     1080

tacggccatc tccccaattg gcggctcctg tcagtcattg tcaagtgtgg ggatgacctt     1140

cggcaagagc ttctggcctt tcaggtgttg aagcaactgc agtccatttg ggaacaggag     1200

cgagtgcccc tttggatcaa gccatacaag attcttgtga tttcggctga tagtggcatg     1260

attgaaccag tggtcaatgc tgtgtccatc catcaggtga agaaacagtc acagctctcc     1320

ttgctcgatt acttcctaca ggagcacggc agttacacca ctgaggcatt cctcagtgca     1380

cagcgcaatt ttgtgcaaag ttgtgctggg tactgcttgg tctgctacct gctgcaagtc     1440

aaggacagac acaatgggaa tatccttttg gacgcagaag gccacatcat ccacatcgac     1500

tttggcttca tcctctccag ctcaccccga aatctgggct ttgagacgtc agcctttaag     1560

ctgaccacag agtttgtgga tgtgatgggc ggcctggatg gcgacatgtt caactactat     1620

aagatgctga tgctgcaagg gctgattgcc gctcggaaac acatggacaa ggtggtgcag     1680

atcgtggaga tcatgcagca aggttctcag cttccttgct tccatggctc cagcaccatt     1740

cgaaacctca aagagaggtt ccacatgagc atgactgagg agcagctgca gctgctggtg     1800

gagcagatgg tggatggcag tatgcggtct atcaccacca aactctatga cggcttccag     1860

tacctcacca acggcatcat gtgacacgct cctcagccca ggagtggtgg ggggtccagg     1920

gcaccctccc tagagggccc ttgtctgaga aaccccaaac caggaaaccc cacctaccca     1980

accatccacc caagggaaat ggaaggcaag aaacacgaag gatcatgtgg taactgcgag     2040

agcttgctga ggggtgggag agccagctgt ggggtccaga cttgttgggg cttccctgcc     2100

cctcctggtc tgtgtcagta ttaccaccag actgactcca ggactcactg ccctccagaa     2160

aacagaggtg acaaatgtga gggacactgg ggcctttctt ctccttgtag gggtctctca     2220

gaggttcttt ccacaggcca tcctcttatt ccgttctggg gcccaggaag tggggaagag     2280

taggttctcg gtacttagga cttgatcctg tggttggcca ctggccatgc tgctgcccag     2340

ctctacccct cccagggacc tacccctccc agggaccgac ccctggccca agctcccctt     2400

gctggcgggc gctgcgtggg ccctgcactt gctgaggttc cccatcatgg gcaaggaagg     2460

gaattcccac agccctccag tgtactgagg gtactggcct agccatgtgg aattccctac     2520

cctgactcct tccccaaacc cagggaaaag agctctcaat tttttatttt taatttttgt     2580

ttgaaataaa gtccttagtt agc                                             2603


<210> 4090
<211> 717
<212> DNA
<213> Homo sapiens

<400> 4090
tttttttttt ttttttttgc cccttctttt cttgttagac tggtttgaac accccagcat       60

ctgtcctgta tttgtcaggt gaaaccagaa gtctttggat aatgaaaccc gtgaccaatt      120

cttacccaag gtggttatga catatgtcag ctgcttcttg gcctatatag ttagaagccg      180

acctctttta ccttgtgaat aattatgtca tcacctccat tattcttttg gtgttctcaa      240

ttgaaatgcc aagcattaaa tgagccacaa agattgaatt cccattatcc ttgaatcaga      300

gcaagcctgt cgtgcagcca tgagttagtg gagaaaaatc cggagttaga gaagattata      360

aatggcagag ccatttaact gtggttagct gttggattct gatactttct taaaaatacg      420

ttcttgcacc aacatcttca ttgggaacag ttcagaaaaa gcaaagagga gagccaacat      480

tcacatttac catggctata ccaataacag tgcttgactg tgacctcttg ctatatggcc      540

gtggtcaccg gacattggac cgttttaagc tggatgatgt gactgatgaa tacttgatgt      600

ccatgtatgg gtttccacgg cagttcattt attacttggt ggagctcttg ggggcgaatc      660

tttctaggcc tactcagcga tccagggcta ttagcccaga gacacaggtc cttgcag         717


<210> 4091
<211> 2909
<212> DNA
<213> Homo sapiens

<400> 4091
ctctccccgg ccgtggcccc cgcggcttag acgcctcctc cgccgccgcc gctcggagca       60

acccgggggc cggatggacg gggccgcggg gcccggtgac ggccctgctc gggaggccct      120

ccagtctctg agccagcggc ttcgggtgca ggagcaggag atggaactgg taaaggcagc      180

cctggcagaa gcccttcgcc tgctgcggct gcaggtgccc ccttcctccc tgcagggctc      240

tggcacacca gctcctccgg gggacagtct tgcagccccc ccaggactgc cacccacgtg      300

caccccttcc ttggtgagcc gaggcaccca gacggagaca gaggtggagc tcaagtcatc      360

ccctggaccc cctggcctga gcaatggacc cccagcccct cagggggcca gcgaagagcc      420

tagcgggacc caatctgaag gagggggcag cagcagcagt ggtgctggct cccctggccc      480

cccggggatc ctcaggccct tgcagccccc acagcgtgct gacacgccgc gaagaaattc      540

ttcctcctcc tcatccccct cagagcggcc tcggcagaag ctctccagga aggcaatctc      600

ctccgccaac ctgttagtgc ggtccgggag cacagagagc cgtgggggaa aagaccccct      660

ctccagccct gggggccctg gatctcggag gagcaattac aatttggaag gcatctcagt      720

gaagatgttc cttcgagggc gccccattac catgtacatc ccgtctggca tccgcagcct      780

tgaggagctg ccgagtggcc caccgccaga gaccctcagc cttgactggg tttatgggta      840

caggggtcgt gactcccgct ctaatctgtt tgtgttgcgc tctggggagg tggtctactt      900

tatcgcctgt gtggtggtgc tgtaccggcc tggaggaggc ccagggggtc ctggaggtgg      960

cggccagaga cattaccggg ggcacacaga ctgcgttcga tgccttgctg ttcaccctga     1020

tggtgttcgg gtagcctcgg gacagacagc tggagtggat aaggatggaa agcccctgca     1080

gcctgtggtt cacatctggg actcagagac gctgttgaaa ctgcaggaga ttggactggg     1140

ggccttcgag cggggtgttg gggccctggc cttttcagct gcggatcagg gtgcctttct     1200

ttgtgtggtg gatgattcca atgagcacat gctgtcggtg tgggactgca gccggggaat     1260

gaagctggct gagatcaaga gtacaaatga ctcagtcctg gccgttggct tcaaccctcg     1320

tgacagcagc tgcatcgtca ccagtgggaa atctcacgtc cacttctgga attggagtgg     1380

tggagtaggg gttcctggga atgggaccct tacccggaaa cagggtgtct ttgggaaata     1440

caagaaaccc aagtttatcc cttgctttgt gttccttccg gatggagaca ttctcactgg     1500

agactcagag gggaacattc tcacctgggg gcggagccct tcagattcca agaccccagg     1560

caggggtggc gccaaagaga cctatgggat tgtggcccag gctcacgctc atgaaggttc     1620

tatcttcgcc ttgtgtctcc ggagggacgg gacagtgctg agtggtggcg ggcgggaccg     1680

ccggctggta cagtgggggc ccgggttggt ggccctccag gaggctgaga ttcccgagca     1740

cttcggggcc gtgcgagcca ttgctgaagg gcttggctct gagctgctgg tgggaaccac     1800

gaagaatgca ttgctgaggg gagacctggc ccagggcttc tcccctgtaa tccagggcca     1860

cactgatgag ctctgggggc tctgcacaca cccctcccag aaccgcttcc tcacctgcgg     1920

ccacgaccgg cagctctgcc tgtgggatgg ggagagccat gcactggcct ggagcatcga     1980

cctcaaggag actggtctct gtgctgactt ccacccgagt ggggcagttg tggccgtagg     2040

actgaacacg gggaggtggt tggttttgga cacagagacc agagagatcg tgtctgatgt     2100

cattgatggc aatgagcagc tctcagtggt ccggtacagc ccagatgggt tgtacctggc     2160

cattggttcc catgacaacg tgatctacat ctatagtgtt tccagtgatg gtgccaaatc     2220

cagccgcttt ggccgctgta tgggtcactc cagcttcatc actcatcttg actggtccaa     2280

ggatgggaat ttcatcatgt ccaattctgg ggactatgag attctttact gggacgtggc     2340

tggaggctgc aagcagctga agaatcgcta tgagagccga gaccgggaat gggctaccta     2400

cacctgtgtg ctgggctttc acgtctacgt acccgtgcgc tcgtgccaag gcgccgagcc     2460

gcatgtacgg gggccacggc agccacgtga ccagcgtccg attcacgcac gacgactcgc     2520

acctcgtctc gctgggcggc aaggacgcca gcatcttcca gtggcgagtg ctgggcgctg     2580

ggggcgcggg gccggcgccc gccacgccct ctcgaacccc ctccctgtcc cccgcctcct     2640

ccctcgacgt ttgatcgctg cctggcggga ccgactggcc cggcggcgtg gccccgcccc     2700

gccctgccct tccctggccc aatcccccac gactaggggc cgactctttc ctggactgac     2760

ttcgagacat tcccgatcgc gcattttcct ggagggcgcg aacggcgccc ctgcacacac     2820

tgtttagacc cgctggctga gccgggcagc cccagcctag gccttgactc ccgctgcctg     2880

ctgaggggca ataaaccaga accaaagtc                                       2909


<210> 4092
<211> 529
<212> DNA
<213> Homo sapiens

<400> 4092
agtctgcttg tggtgtgagt ggtgcctgtg gcaggccctc tgcagccagg gtcggcgtaa       60

tggataacct gtgatgagtt ccattagaga aaacgtggaa aaagcaggga tggatttacc      120

cttgtagaag cagggttagg cttgctgagg ggcaggcaca ggagtcctgg ctgagctcat      180

ggcctgaggc tgcctagcgg ccacggggaa tggttgcaat ggcggaggca gaggcagggg      240

tggcagtgga ggtccgtgga ctgccccctg ccgtgcccga cgagctgctc actctctact      300

ttgaaaaccg ccgacgctct ggagggggac ctgtgttgag ctggcagaga ctgggctgtg      360

ggggcgtcct caccttcaga gagcctgcag acgccgagag ggtcttggcc caggcagatc      420

acgaactaca tggtgcccag ctgagcctgc ggccagctcc accacgagcc cctgcacgcc      480

tgctgctcca aggactgccc cctggcacca cgccccagcg cttggagca                  529


<210> 4093
<211> 603
<212> DNA
<213> Homo sapiens

<400> 4093
ttttgggcgc ttcgctgatg gtgtcggtga gcgcgtttcc cgcctgagcg caactagcgg       60

cgggtcgtgg gcacctccag gctcagaagg aaagaaaaca tctcccagga ccagatgtgg      120

agtagatggg agttggagag aagctgaagc ccaggcccag caacaggctg ggggcccagg      180

tgcttcgggg gtcccagcca ttaacagagc ttcgtgcagg agagcttgtt tcatatccat      240

atcccactgt attcctgcta atctgctaat gcagtaaatt ggaggaaaac tgttaccagg      300

ataacctgta atgggcaagg agccacaaag aagaaaacat ttcttttaat ttttaaactt      360

ggtttgaaag accagcatgt tttggaaatt tgatcttcac tcatcatccc acatagacac      420

acttctagaa agagaagatg taacactgaa ggagttaatg gatgaggaag atgttttaca      480

ggaatgtaaa gctcagaacc gcaaacttat agagtttctg ttaaaagcag aatgtctcga      540

agatttagtc tcattcatta tagaagaacc acctcaagac atggatgaaa agatcagata      600

caa                                                                    603


<210> 4094
<211> 1375
<212> DNA
<213> Homo sapiens

<400> 4094
gtcacgtgtt gttgttgggc cgggaaagct gcttccgggt caatgcagga cactgggctc       60

cggcggccag agtgggggac tagcatttta agaaagaaag atggatcaac ctagtggaag      120

aagtttcatg caagtattat gtgaaaaata tagtcctgaa aattttcctt atcgccgtgg      180

cccggggatg ggagtccatg tcccagccac acctcagggc tctcctatga aagatcgcct      240

caacctccca agtgtactag tgttgaacag ctgtggaata acctgtgcag gagatgaaaa      300

agaaattgct gctttctgcg ctcatgtgtc ggaactagat ctttctgaca acaaactcga      360

agactggcat gaggtcagta aaattgtgtc aaatgttcct cagttggagt ttctaaacct      420

gagttccaac cctctgaatt tgtcggtttt agaaagaaca tgtgctgggt ccttctctgg      480

ggttcgcaaa cttgtcctca acaacagcaa agcttcttgg gagacggtcc acatgatact      540

acaggagtta ccagatttgg aggagctctt cctgtgcctt aatgactatg aaacagtgtc      600

ttgtccttct atttgctgtc attctcttaa gctactacat ataacagaca ataacctcca      660

agactggact gaaatacgaa agttaggagt tatgtttcct tcactggata ccctcgtcct      720

ggccaacaat catttgaatg ctattgagga gcctgatgat tcattggcca ggttgtttcc      780

taatcttcga tccatcagcc tccacaagtc aggtttgcag tcctgggaag acattgataa      840

actaaattca tttcccaaac tggaagaagt gagattgtta ggaattcctc ttctgcagcc      900

atataccacc gaggagcgaa ggaaattggt aatagccaga ttgccatcag tttccaaact      960

taatggcagc gttgttactg atggtgaacg agaagattct gagagatttt ttattcgtta     1020

ctatgtggat gttccacagg aagaagtgcc attcaggtat catgaactga tcactaaata     1080

tgggaagttg gagcctttgg cagaagtgga cctaagaccc cagagcagtg caaaagtaga     1140

agtccacttt aacgatcagg tggaagaaat gagcattcgt ctggaccaaa cagtggcaga     1200

actaaagaaa cagttaaaaa ctctagtaca attacccaca agcaacatgc ttctctacta     1260

ttttgaccat gaagcaccct ttggcccaga ggaaatgaag tacagctctc gggcattgca     1320

ttcctttggc attagggatg gagataaaat ttacgtggaa tccaaaacaa aataa          1375


<210> 4095
<211> 551
<212> DNA
<213> Homo sapiens

<400> 4095
gagaaattgg gcctggcatt ttgagtgact tctgagatta tctgaatctc acactttgct       60

gacctctttt tggagggcat tgcctgtggc ctggcccaga gaggatgggc aggtgttttc      120

tgagtcacac agcagaccaa gtgtggagac aggtgtgtct ctagtcctcg tggttgcctg      180

ccccactccc tgccgagacg cctgccagaa aggtcaccta tcctgaaccc cagcaagcct      240

gaaacagctc agccaagcac cctgcgatgg aagctgcaga tgcctccagg agcaacgggt      300

cgagcccaga agccagggat gcccggagcc cgtcgggccc cagtggcagc ctggagaatg      360

gcaccaaggc tgacggcaag gatgccaaga ccaccaacgg gcacggcggg gaggcagctg      420

agggcaagag cctgggcagc gccctgaagc caggggaagg taggagcgcc ctgttcgcgg      480

gcaatgagtg gcggcgaccc atcatccagt ttgtcgagtc cggggacgac aagaactcca      540

actacttcag c                                                           551


<210> 4096
<211> 3228
<212> DNA
<213> Homo sapiens

<400> 4096
gtctggctcg ggaggcgttc ctggggccaa ggccatggcc ccgcggctgc agctggagaa       60

ggcggcctgg cgctgggcgg agacggtgcg gcccgaggag gtgtcgcagg agcacatcga      120

gaccgcttac cgcatctggc tggagccctg cattcgcggc gtgtgcagac gaaactgcaa      180

aggaaatccg aattgcttgg ttggtattgg tgagcatatt tggttaggag aaatagatga      240

aaatagtttt cataacatcg atgatcccaa ctgtgagagg agaaaaaaga actcatttgt      300

gggcctgact aaccttggag ccacttgtta tgtcaacaca tttcttcaag tgtggtttct      360

caacttggag cttcggcagg cactctactt atgtccaagc acttgtagtg actacatgct      420

gggagacggc atccaagaag aaaaagatta tgagcctcaa acaatttgtg agcatctcca      480

gtacttgttt gccttgttgc aaaacagtaa taggcgatac attgatccat caggatttgt      540

taaagccttg ggcctggaca ctggacaaca gcaggatgct caagaatttt caaagctctt      600

tatgtctcta ttggaagata ctttgtctaa acaaaagaat ccagatgtgc gcaatattgt      660

tcaacagcag ttctgtggag aatatgccta tgtaactgtt tgcaaccagt gtggcagaga      720

gtctaagctt ttgtcaaaat tttatgagct ggagttaaat atccaaggcc acaaacagtt      780

aacagattgt atctcggaat ttttgaagga agaaaaatta gaaggagaca atcgctattt      840

ttgcgagaac tgtcaaagca aacagaatgc aacaagaaag attcgacttc ttagccttcc      900

ttgcactctg aacttgcagc taatgcgttt tgtctttgac aggcaaactg gacataagaa      960

aaagctgaat acctacattg gcttctcaga aattttggat atggagcctt atgtggaaca     1020

taaaggtggg tcctacgtgt atgaactcag cgcagtcctc atacacagag gagtgagtgc     1080

ttattctggc cactacatcg cccacgtgaa agatccacag tctggtgaat ggtataagtt     1140

taatgatgaa gacatagaaa agatggaggg gaagaaatta caactaggga ttgaggaaga     1200

tctagaacct tctaagtctc agacacgtaa acccaagtgt ggcaaaggaa ctcattgctc     1260

tcgaaatgca tatatgttgg tttatagact gcaaactcaa gaaaagccca acactactgt     1320

tcaagttcca gcctttcttc aagagctggt agatcgggat aattccaaat ttgaggagtg     1380

gtgtattgaa atggctgaga tgcgtaagca aagtgtggat aaaggaaaag caaaacacga     1440

agaggttaag gagctgtacc aaaggttacc tgctggagct gagccctatg agtttgtctc     1500

tctggaatgg ctgcaaaagt ggttggatga atcaacacct accaaaccta ttgataatca     1560

cgcttgcctg tgttcccatg acaagcttca cccggataaa atatcaatta tgaagaggat     1620

atctgaatat gcagctgaca ttttctatag tagatatgga ggaggtccaa gactaactgt     1680

gaaagccctg tgtaaggaat gtgtagtaga acgttgtcgc atattgcgtc tgaagaacca     1740

actaaatgaa gattataaaa ctgttaataa tctgctgaaa gcagcagtaa agggcagcga     1800

tggattttgg gtggggaagt cctccttgcg gagttggcgc cagctagctc ttgaacagct     1860

ggatgagcaa gatggtgatg cagaacaaag caacggaaag atgaacggta gcaccttaaa     1920

taaagatgaa tcaaaggaag aaagaaaaga agaggaggaa ttaaatttta atgaagatat     1980

tctgtgtcca catgctgttt tttttttttc caaatatatt tttttaaact caggtgagtt     2040

atgcatatct gaaaatgaaa gaaggcttgt ttctaaagag gcttggagca aactgcagca     2100

gtactttcca aaggctcctg agtttccaag ttacaaagag tgctgttcac agtgcaagat     2160

tttagaaaga gaaggggaag aaaatgaagc cttacataag atgattgcaa acgagcaaaa     2220

gacttctctc ccaaatttgt tccaggataa aaacagaccg tgtctcagta actggccaga     2280

ggatacggat gtcctctaca tcgtgtctca gttctttgta gaagagtggc ggaaatttgt     2340

tagaaagcct acaagatgca gccctgtgtc atcagttggg aacagtgctc ttttgtgtcc     2400

ccacgggggc ctcatgttta catttgcttc catgaccaaa gaagattcta aacttatagc     2460

tctcatatgg cccagtgagt ggcaaatgat acaaaagctc tttgttgtgg atcatgtaat     2520

taaaatcacg agaattgaag tgggagatgt aaacccttca gaaacacagt atatttctga     2580

gcccaaactc tgtccagaat gcagagaagg cttattgtgt cagcagcaga gggacctgcg     2640

tgaatacact caagccacca tctatgtcca taaagttgtg gataataaaa aggtgatgaa     2700

ggattcggct ccggaactga atgtgagtag ttctgaaaca gaggaggaca aggaagaagc     2760

taaaccagat ggagaaaaag atccagattt taatcaaagc aatggtggaa caaagcggca     2820

aaagatatcc catcaaaatt atatagccta tcaaaagcaa gttattcgcc gaagtatgcg     2880

acatagaaaa gttcgtggtg agaaagcact tctcgtttct gctaatcaga cgttaaaaga     2940

attgaaaatt cagatcatgc atgcattttc agttgctcct tttgaccaga atttgtcaat     3000

tgatggaaag attttaagtg atgactgtgc caccctaggc acccttggcg tcattcctga     3060

atctgtcatt ttattgaagg ctgatgaacc aattgcagat tatgctgcaa tggatgatgt     3120

catgcaagtt tgtatgccag aagaagggtt taaaggtact ggtcttcttg gacattaatc     3180

tttgaatact tgctgactgc taagaaatga ccagagggga agaggagt                  3228


<210> 4097
<211> 2566
<212> DNA
<213> Homo sapiens

<400> 4097
cccccccccc ccggccatta ccgaagcgga tgaaaacaaa cactaacgat ggcggcgccg       60

ggaagcgacc ggctgctggg cttaaggcgg gagtgaccgc ttaaccagtg agggaagcac      120

tgaagagcgc cagtcgacgt gggtgcgaca actcgcggag tcttaggagc aaaacgtctg      180

gggcctgcga gccaggaccc ttctgaagcc ttaggtgtct atcggcgacg tgtacggtca      240

ctgcagctcc ggagcgcgga accctcagcc aggaggcgcg gctggtcggt cccaggtccc      300

ggcctccgta atgagagccc ggaaccactc tttgtgccgc agcttcgcag tggaacgacc      360

tgtggaaacc tgtgatccat tctcattaaa taaatctctg gattcctata ggcaatggaa      420

actgatctca attcccagga cagaaaggac ctggacaagt ttattaaatt ttttgccctc      480

aagactgtcc aagtgattgt ccaggctcgg cttggtgaaa agatttgcac tcgttcatca      540

tcttctccaa cgggttcaga ttggttcaac ttagcaatca aagacatccc agaggttaca      600

catgaagcaa agaaggcact ggcaggacag ctgcctgcag tcgggaggtc catgtgtgtg      660

gagatttcac ttaagacttc tgagggagat tccatggagc tggaaatatg gtgtcttgaa      720

atgaatgaaa agtgtgataa agaaatcaaa gtttcctaca cggtgtacaa cagactgtca      780

ttgctgctga agtcccttct tgctataact agggtgacac cagcctatag gctctccagg      840

aaacaagggc atgaatatgt catattatac aggatatatt ttggagaagt tcagctgagt      900

ggcttaggag aaggcttcca gacagttcgt gttgggacag tgggcacccc tgtgggcacc      960

atcactcttt cttgtgctta cagaattaac ttggcattca tgtctaccag gcaatttgag     1020

aggaccccac ctatcatggg gattattatt gatcactttg tggaccgtcc ctatcccagc     1080

tcctctccca tgcacccctg caattacaga actgctggtg aggacactgg agtaatatac     1140

ccgtctgtag aagactctca agaagtgtgt accacctctt tttccacctc cccaccatcc     1200

cagctgatgg ttcctgggaa ggaaggtggg gtaccccttg ctcccaacca gcctgtccat     1260

ggtacccagg ctgaccagga gagactggca acctgcaccc cttctgacag aacccactgt     1320

gctgccacac cctccagtag tgaggatact gaaaccgtat caaacagcag tgagggacgg     1380

gcctcccctc acgatgtctt ggagaccatc tttgtccgaa aagtgggggc ttttgtcaac     1440

aaacccatta accaggtgac cctgacgagt ttggatatac cctttgccat gtttgctccc     1500

aagaatttgg agctggagga taccgatcca atggtgaatc ctccagattc cccagagact     1560

gaatctcctc tccagggcag cctgcactca gatggctcca gcgggggcag cagtggcaat     1620

acccatgatg actttgttat gatagacttt aaaccagctt tttctaaaga tgacattctt     1680

ccgatggacc tggggacctt ctatcgggag tttcagaacc cacctcagct gagcagcctc     1740

tccatagata ttggagcaca gtccatggct gaagacttgg actcattacc agagaagctg     1800

gctgtgcatg agaagaatgt ccgcgagttt gatgcctttg tggaaaccct gcagtaaaag     1860

tatccttgag tcccagcagc accccctttt tgtggcccca gggcataagc agcctcccat     1920

gcatcagctg ctcccacccc tcatcctgct ctgagccagg tggaagggag gctggcttct     1980

cccatgggga cccagaagtc cctactcttg gacctcctgg agactccgtg gcggcagtca     2040

agcccagtgc ccagttggag aagactcacg tgctggcctt ggagatggga agaaccttcg     2100

tacgaaaaag ccctcagcag ggccatctgt gtgccctgcc catcaccaac tgcttcccaa     2160

gggtgtcatc ctgttcctcc tgctgccggc ctcctgcctg ggcctgcctt gcagctggcc     2220

ccttccctgc ctgctgtcac catccactgt ttgacattcc agctggtggc caagagattg     2280

gtgtggagtc gcagaaagag gaaggagaca gtgccaggag gaagaaggaa ggagtccctt     2340

agctctcttc attgtcccct ttacttcctg ctatcttctt ctcctcttct tctctctctt     2400

gcctctatgc ctgtatttct ggcaatatga caggcctgcc tacccaagat cagaactcca     2460

aaaccactcc cacccctgaa ggtcgggagg gtctgagcag ccctggtggc tgcctgtgct     2520

caggtcctca gctccatggg aaataaaaat ggcaccctga atctct                    2566


<210> 4098
<211> 3228
<212> DNA
<213> Homo sapiens

<400> 4098
cgtgggcacc tccagataag aaaacaagct cagagagatg tggtgacttg ctcaaatagt       60

gacagaactt cctcggccat atggaggggt catataatac ccttgtgtct tcagtttgag      120

gagagcttgt ttcatatcca tatcccactg tattcctgct aatctgctaa tgcagtaaat      180

tggaggaaaa ctgttaccag gataacctgt aatgggcaag gagccacaaa gaagaaaaca      240

tttcttttaa tttttaaact tggtttgaaa gaccagcatg ttttggaaat ttgatcttca      300

ctcatcatcc cacatagaca cacttctaga aagagaagat gtaacactga aggagttaat      360

ggatgaggaa gatgttttac aggaatgtaa agctcagaac cgcaaactta tagagtttct      420

gttaaaagca gaatgtctcg aagatttagt ctcattcatt atagaagaac cacctcaaga      480

catggatgaa aagatcagat acaagtatcc aaatatatct tgtgagttgc tcacttctga      540

tgtctcccag atgaatgata gactgggaga agatgaatcc ttgctaatga aattatatag      600

cttcctccta aacgattccc ctttgaatcc actacttgcc agtttcttca gcaaggtgct      660

aagtattctt atcagcagaa aaccagaaca gattgtggat ttcttaaaga agaagcatga      720

ttttgtagac cttattataa agcacatagg aacttctgct atcatggatt tgttgctcag      780

gctcctgacg tgtatcgaac ctccacagcc caggcaagat gtgctgaatt ggttaaatga      840

ggagaaaatt atccagaggc ttgtggaaat agttcatcca tcgcaagaag aagatcgaca      900

ttcaaatgca tcacaatcac tttgtgaaat tgttcgcctg agcagagacc agatgttaca      960

aattcagaac agtacagagc ccgaccccct gcttgccact ctagaaaagc aagaaattat     1020

agagcagctt ctatcaaata ttttccacaa ggagaaaaat gagtcagcca tagtcagtgc     1080

aatccagata ttgctgactt tacttgagac acgacgacca acatttgaag gccatataga     1140

gatctgccca ccaggcatga gccattcagc ttgttcagta aacaagagtg ttctagaagc     1200

catcagagga agacttggat cttttcatga actcctgctg gagccaccca agaacatgtt     1260

cttcaagtat acatggaata actttttgca tacacaagtg gaaatttgta ttgcactgat     1320

tcttgcaagt ccttttgaaa acacagaaaa tgccacaatt accgatcaag actccactgg     1380

tgataatttg ttattaaaac atcttttcca aaaatgtcaa ttaatagaac gaatacttga     1440

agcctgggaa atgaatgaga agaaacaggc tgagggagga agacggcatg gttacatggg     1500

acacctaacg aggatagcta actgtatcgt gcacagcact gacaagggcc ccaacagtgc     1560

attagtgcag cagcttatca aagatcttcc cgacgaagtc agggaacgat gggagacgtt     1620

ctgcacaagc tccttaggag aaactaacaa gaggaacacg gtagatctag ccttttctga     1680

ttatcagatg caacaaatga cgtccaattt tattgaccag tttggcttca acgatgagaa     1740

gtttgcagat caagatgaca ttggcaatgt ttcttttgat cgagtatcag acatcaactt     1800

tactctcaat acaaatgaaa gtggaaatat tgccttgttt gaagcatgtt gtaaggaaag     1860

aatacaacag tttgatgatg gtggctctga tgaggaagat atatgggagg aaaagcacat     1920

cgcattcaca ccagaatccc aaagacgatc cagctcgggg agtacagaca gtgaggaaag     1980

tacagactct gaagaagaag atggagcaaa gcaagacttg tttgaaccca gcagtgccaa     2040

cacggaggat aaaatggagg tggacctgag tgaaccaccc aactggtcag ctaactttga     2100

tgtcccaatg gaaacaaccc acggtgctcc attggattct gtgggatctg atgtctggag     2160

cacagaggag ccgatgccaa ctaaagagac gggctgggct tctttttcag agttcacgtc     2220

ttccctgagc acaaaagatt ctttaaggag taattctcca gtggaaatgg aaaccagcac     2280

tgaacccatg gaccctctga ctcccagtgc ggctgccctg gcagtgcagc cagaagcggc     2340

aggcagtgtg gccatggaag ccagctctga cggagaggag gatgcagaaa gtacagacaa     2400

ggtaactgag acagtgatga atggcggcat gaaggaaacg ctcagcctca ctgtagatgc     2460

caagacagag actgcggtct tcaaaagtga ggaagggaaa ctgtctacct ctcaagatgc     2520

tgcttgtaaa gacgcagagg agtgtcccga gactgcagag gcgaagtgcg cggcgcccag     2580

gcctcccagc agcagtcccg agcagagtgg tgtggagatt ccagcactcc caggacagtg     2640

gagtcagcag taagccctgg gacaggtggc aagggtgggt cccttgacct ttgcacgcct     2700

cctcaggaac cccctttccc gggtgagccc ctctctgaag agactgtcct tgggcctcct     2760

ctggaagcag cacccccaga ggacagggct cctcctgctt gcctcagggc tgcctgactt     2820

gaatggcgtt ggacctcggg gattactggt agataatatg ctctggtctc gcctggtggt     2880

gagttttgcc agccatggcc agggtttggc tccactggtg gcacacgtgg cctccgtggt     2940

atggacctgg tggcttctcc atcccactgt ggcctctgtg gtatggacct ggtggcttct     3000

ccatcctacc caaggtaaca gtgtcttgct tcatcccact gactgctggg agagagcctc     3060

tgggactttt ctttggggca tcattttgtt ttgtctttcg tagcagggaa aggatatgac     3120

aatggggagg acagttcttt tggaggttgg aggggccaag ccaaggacag gagcaagtgt     3180

gccctcattt tgtttctact tttaatttct gtgtgttggc catactga                  3228


<210> 4099
<211> 1688
<212> DNA
<213> Homo sapiens

<400> 4099
gcgattttcc ttcggctgag gcaggagctt taggaccact tgctttcagg aaaagaaaat       60

gagtaactct ctcttcagga tggtgatggg gcctggccag tccaaggagg ctcctgggtg      120

gtcactgagt gggaggtcat cttcactgtt tcctctcctc catggtagga aatcactgac      180

caggacatgt ttggagatgc cagcacgagt ctggttgtgc cggagaaagt caaaactccc      240

atgaagtcca gtaaaacgga tctccagggc tctgcctccc ccagcaaagt ggagggggtg      300

cacacacccc ggcagaagag gagcacgccc ctgaaggagc ggcagctctc caagccccta      360

agtgagagga ccaacagttc cgacagcgag cgctccccag atctgggcca cagcacgcag      420

attccaagaa aggtggtgta tgaccagctc aatcagatcc tggtgtcaga tgcagccctc      480

ccagaaaatg tcattctggt gaacaccact gactggcagg gccagtatgt ggctgagctg      540

ctccaggacc agcggaagcc tgtggtgtgc acctgctcca ccgtggaggt ccaggccgtg      600

ctgtccgccc tgctcacccg gatccagcgc tactgcaact gcaactcttc catgccgagg      660

ccagtgaagg tggctgctgt gggaggccag agctacctga gctccatcct caggttcttt      720

gtcaagtccc tggccaacaa gacctccgac tggcttggct acatgcgctt cctcatcatc      780

cccctcggtt ctcaccctgt ggccaaatac ttggggtcag tcgacagtaa atacagtagt      840

tccttcctgg attctggttg gagagatctg ttcagtcgct cggagccacc agtgtcagag      900

caactggacg tggcagggcg ggtgatgcag tacgtcaacg gggcagccac gacacaccag      960

cttcccgtgg ccgaagccat gctgacttgc cggcataagt tccctgatga agactcctat     1020

cagaagttta ttcccttcat tggcgtggtg aaggtgggtc tggttgaaga ctctccctcc     1080

acagcaggcg atggggacga ttctcctgtg gtcagcctta ctgtgccctc cacatcacca     1140

ccctccagct cgggcctgag ccgagacgcc acggccaccc ctccctcctc cccatctatg     1200

agcagcgccc tggccatcgt ggggagccct aatagcccat atggggacgt gattggcctc     1260

caggtggact actggctggg ccaccccggg gagcggagga gggaaggcga caagagggac     1320

gccagctcga agaacaccct caagagtgtc ttccgctcag tgcaggtgtc ccgcctgccc     1380

catagtgggg aggcccagct ttctggcacc atggccatga ctgtggtcac caaagaaaag     1440

aacaagaaag ttcccaccat cttcctgagc aagaaacccc gagaaaagga ggtggattct     1500

aagagccagg tcattgaagg catcagccgc ctcatctgct cagccaagca gcagcagact     1560

atgctgagag tgtccatcga tggggtcgag tggagtgaca tcaagttctt ccagctggca     1620

gcccagtggc ccacccatgt caagcacttt ccagtgggac tcttcagtgg cagcaaggcc     1680

acctgagg                                                              1688


<210> 4100
<211> 696
<212> DNA
<213> Homo sapiens

<400> 4100
attaccttgt caccttctga ggttacttgt gacgatgcca atgatggtgt gagatgggga       60

ggtgcaggca ggacagaaag ctgcaggaat gggcaggcaa gacctgaggc gggaggaagg      120

ctgtgctgca atgcacattc ttggagacca agggtgggga accgcccatg ctcagcacct      180

ggcagcaggg ttaggcttgc tgaggggcag gcacaggagt cctggctgag ctcatggcct      240

gaggctgcct agcggccacg gggaatggtt gcaatggcgg aggcagaggc aggggtggca      300

gtggaggtcc gtggactgcc ccctgccgtg cccgacgagc tgctcactct ctactttgaa      360

aaccgccgac gctctggagg gggacctgtg ttgagctggc agagactggg ctgtgggggc      420

gtcctcacct tcagagagcc tgcagacgcc gagagggtct tggcccaggc agatcacgaa      480

ctacatggtg cccagctgag cctgcggcca gctccaccac gagcccctgc acgcctgctg      540

ctccaaggac tgccccctgg caccacgccc cagcgcttgg agcagcatgt ccaggccttg      600

ctgcgggcct cggggctccc agtacagcct tgctgtgcct tggccagccc ccggccagac      660

cgggctctgg tccagttgcc caagcccctt tctgag                                696


<210> 4101
<211> 703
<212> DNA
<213> Homo sapiens

<400> 4101
gggaagggtc agaccaccat ccgggtactc taaggtacat aaaagagtcc tccctccccc       60

ttctccttca cccccaagtg tctcccacga ctgccctccc cgacctctag ctgaccatgg      120

catcagaggc agaaaaaaca ttccatcggt ttgctgcgtt tggagaatca tcaagcagtg      180

gcactgaaat gaacaacaag aacttctcca agctgtgcaa agactgtggc atcatggatg      240

gcaagacagt cacctccacg gacgtggaca tcgtgttcag caaagtcaag gccaagaacg      300

cccgaaccat cacgtttcaa cagttcaaag aggcagtgaa ggaactgggc cagaagcgct      360

tcaaagggaa gagtccagat gaagtcctgg agaacattta tggactcatg gagggcaaag      420

acccagccac cactggcgct actaaagcaa caacagtggg tgcagtggac cgtttgacag      480

acaccagcaa gtacaccggc acccacaagg agcgctttga tgagagtggc aagggcaagg      540

gcattgcggg acgggaagag atgactgaca acacaggcta tgtgagtggt tacaagggtt      600

ctggcaccta cgataagaag accaagtaga gaggagcttc atctcagcct gctagccccc      660

tgaccctgca tgtttaacac cagggagctt ggaaaacaat aaa                        703


<210> 4102
<211> 588
<212> DNA
<213> Homo sapiens

<400> 4102
cagtccccac ttccctcctc actctcttgg gagcgaggcc tcttaccatt gttctggcgt       60

gaggaaaggc ctgctgttgc ctcaccaagc ccactcgtga acccgctgat gccgagcccg      120

cctgcctgag tcttgatcgc tgacttgagc tcgtgattct cccgaatgag ccgcaccaac      180

ttcttcagtt cctcattttc ccgcaccagc ctctctatct gatgccgaag cccttcataa      240

ttgcagggtt aggcttgctg aggggcaggc acaggagtcc tggctgagct catggcctga      300

ggctgcctag cggccacggg gaatggttgc aatggcggag gcagaggcag gggtggcagt      360

ggaggtccgt ggactgcccc ctgccgtgcc cgacgagctg ctcactctct actttgaaaa      420

ccgccgacgc tctggagggg gacctgtgtt gagctggcag agactgggct gtgggggcgt      480

cctcaccttc agagagcctg cagacgccga gagggtcttg gcccaggcag atcacgaact      540

acatggtgcc cagctgagcc tgcggccagc tccaccacga gcccctgc                   588


<210> 4103
<211> 2030
<212> DNA
<213> Homo sapiens

<400> 4103
gaagcggatg aaaacaaaca ctaacgatgg cggcgccggg aagcgaccgg ctgctgggct       60

taaggcggga gtgaccgctt aaccagtgag ggaagcactg aagagcgcca gtcgacgtgg      120

gtgcgacaac tcgcggagtc ttaggagcaa aacgtctggg gcctgcgagc caggaccctt      180

ctgaagcctt aggtgtctat cggcgacgtg tacggtcact gcagctccgg agcgcggaac      240

cctcagccag gaggcgcggc tggtcggtcc caggtcccgg cctccgtaat gagagcccgg      300

aaccactctt tgtgccgcag cttcgcagac tgtccaagtg attgtccagg ctcggcttgg      360

tgaaaagatt tgcactcgtt catcatcttc tccaacgggt tcagattggt tcaacttagc      420

aatcaaagac atcccagagg ttacacatga agcaaagaag gcactggcag gacagctgcc      480

tgcagtcggg aggtccatgt gtgtggagat ttcacttaag acttctgagg gagattccat      540

ggagctggaa atatggtgtc ttgaaatgaa tgaaaagtgt gataaagaaa tcaaagtttc      600

ctacacggtg tacaacagac tgtcattgct gctgaagtcc cttcttgcta taactagggt      660

gacaccagcc tataggctct ccaggaaaca agggcatgaa tatgtcatat tatacaggat      720

atattttgga gaagttcagc tgagtggctt aggagaaggc ttccagacag ttcgtgttgg      780

gacagtgggc acccctgtgg gcaccatcac tctttcttgt gcttacagaa ttaacttggc      840

attcatgtct accaggcaat ttgagaggac cccacctatc atggggatta ttattgatca      900

ctttgtggac cgtccctatc ccagctcctc tcccatgcac ccctgcaatt acagaactgc      960

tggtgaggac actggagtaa tatacccgtc tgtagaagac tctcaagaag tgtgtaccac     1020

ctctttttcc acctccccac catcccagct gatggttcct gggaaggaag gtggggtacc     1080

ccttgctccc aaccagcctg tccatggtac ccaggctgac caggagagac tggcaacctg     1140

caccccttct gacagaaccc actgtgctgc cacaccctcc agtagtgagg atactgaaac     1200

cgtatcaaac agcagtgagg gacgggcctc ccctcacgat gtcttggaga ccatctttgt     1260

ccgaaaagtg ggggcttttg tcaacaaacc cattaaccag gtgaccctga cgagtttgga     1320

tatacccttt gccatgtttg ctcccaagaa tttggagctg gaggataccg atccaatggt     1380

gaatcctcca gattccccag agactgaatc tcctctccag ggcagcctgc actcagatgg     1440

ctccagcggg ggcagcagtg gcaataccca tgatgacttt gttatgatag actttaaacc     1500

agctttttct aaagatgaca ttcttccgat ggacctgggg accttctatc gggagtttca     1560

gaacccacct cagctgagca gcctctccat agatattgga gcacagtcca tggctgaaga     1620

cttggactca ttaccagaga agctggctgt gcatgagaag aatgtccgcg agtttgatgc     1680

ctttgtggaa accctgcagt aaaagtatcc ttgagtccca gcagcacccc ctttttgtgg     1740

ccccagggca taagcagcct cccatgcatc agctgctccc acccctcatc ctgctctgag     1800

ccaggtggaa gggaggctgg cttctcccat ggggacccag aagtccctac tcttggacct     1860

cctggagact ccgtggcggc agtcaagccc agtgcccagt tggagaagac tcacgtgctg     1920

gccttggaga tgggaagaac cttcgtacga aaaagccctc agcagggcca tctgtgtgcc     1980

ctgcccatca ccaactgctt cccaagggtg tcatcctgtt cctcctgctg                2030


<210> 4104
<211> 2469
<212> DNA
<213> Homo sapiens

<400> 4104
ggagagcgct ggtggtaggg aggcttctcc cggttctgtg agcagcagga ccctcccgag       60

ggcctgaccg tggaggtagc actgcacacc cactccctgt gggccggagc caggaggcac      120

ttcctgggtg tcggagccca gaaggaaacc agtggccggg aagcaccagc tgggtgtggg      180

acaggcactg gcctcagacc ggggccacac tgaggtctgc ccttctcccg ctggccgcca      240

cccaagacac catgagccag tccggggccg tgagctgctg cccgggtgcc accaatggca      300

gcctgggccg gtccgacggt gtggccaaga tgagccccaa ggacctgttt gagcagagga      360

agaagtattc caactccaac gtcatcatgc acgagacctc gcagtaccac gtccagcacc      420

tggccacatt catcatggac aagagcgaag ccatcacgtc tgtggacgac gccatccgga      480

agctggtgca gctgagctcc aaggagaaga tctggaccca ggagatgctg ctgcaggtga      540

acgaccagtc gctgcggctg ctggacatcg agtcacagga ggagctggaa gacttcccgc      600

tgcccacggt gcagcgcagc cagacggtcc tcaaccagct gcgctacccg tctgtgctgc      660

tgctcgtgtg ccaggactcg gagcagagca agccggatgt ccacttcttc cactgcgatg      720

aggtggaggc agagctggtg cacgaggaca tcgagagcgc gttggccgac tgccggctgg      780

gcaagaagat gcggccgcag accctgaagg gacaccagga gaagattcgg cagcggcagt      840

ccatcctgcc tcctccccag ggcccggcgc ccatcccctt ccagcaccgc ggcggggatt      900

ccccggaggc caagaatcgc gtgggcccgc aggtgccact cagcgagcca ggtttccgcc      960

gtcgggagtc gcaggaggag ccgcgggccg tgctggctca gaagatagag aaggagacgc     1020

aaatcctcaa ctgcgccctg gacgacatcg agtggtttgt ggcccggctg cagaaggcag     1080

ccgaggcttt caagcagctg aaccagcgga aaaaggggaa gaagaagggc aagaaggcgc     1140

cagcagaggg cgtcctcaca ctgcgggcac ggcccccctc tgagggcgag ttcatcgact     1200

gcttccagaa aatcaagctg gcgattaact tgctggcaaa gctgcagaag cacatccaga     1260

accccagcgc cgcggagctc gtgcacttcc tcttcgggcc tctggacctg atcgtcaaca     1320

cctgcagtgg cccagacatc gcacgctccg tctcctgccc actgctctcc cgagatgccg     1380

tggacttcct gcgcggccac ctggtcccta aggagatgtc gctgtgggag tcactgggag     1440

agagctggat gcggccccgt tccgagtggc cgcgggagcc acaggtgccc ctctacgtgc     1500

ccaagttcca cagcggctgg gagcctcctg tggatgtgct gcaggaggcc ccctgggagg     1560

tggaggggct ggcgtctgcc cccatcgagg aggtgagtcc agtgagccga cagtccataa     1620

gaaactccca gaagcacagc cccacttcag agcccacccc cccgggggat gccctaccac     1680

cagtcagctc cccacatact cacaggggct accagccaac accagccatg gccaagtacg     1740

tcaagatcct gtatgacttc acagcccgaa atgccaacga gctatcggtg ctcaaggatg     1800

aggtcctaga ggtgctggag gacggccggc agtggtggaa gctgcgcagc cgcagcggcc     1860

aggcggggta cgtgccctgc aacatcctag gcgaggcgcg accggaggac gccggcgccc     1920

cgttcgagca ggccggtcag aagtactggg gccccgccag cccgacccac aagctacccc     1980

caagcttccc ggggaacaaa gacgagctca tgcagcacat ggacgaggtc aacgacgagc     2040

tcatccggaa aatcagcaac atcagggcgc agccacagag gcacttccgc gtggagcgca     2100

gccagcccgt gagccagccg ctcacctacg agtcgggtcc ggacgaggtc cgcgcctggc     2160

tggaagccaa ggccttcagc ccgcggatcg tggagaacct gggcatcctg accgggccgc     2220

agctcttctc cctcaacaag gaggagctga agaaagtgtg cggcgaggag ggcgtccgcg     2280

tgtacagcca gctcaccatg cagaaggcct tcctggagaa gcagcaaagt gggtcggagc     2340

tggaagaact catgaacaag tttcattcca tgaatcagag gaggggggag gacagctagg     2400

cccagctgcc ttgggctggg gcctgcggag gggaagccca cccacaatgc atggagtatt     2460

atttttata                                                             2469


<210> 4105
<211> 549
<212> DNA
<213> Homo sapiens

<400> 4105
aagggtcctc aggggttctt ccctggaagc gggaggtgca gtgctttact tccaactatg       60

tggtcaattt tgtttacaag agctcctgaa ggaagcacta aacatggaaa ggaacaaccg      120

gtaccagcca ctgcaaaaac atgccaaatt gtaaagacca tcgatgttag gaagaaactg      180

cctcaactaa tgagcaaaat aaccagctaa catcgtaatg acaggatcaa attcacacat      240

aacgatatta accttaaagg tgttacctca ttttgaaagt cttgggaaac aggaaaaaat      300

tcctaacaaa atgtcagctt ttcgaaatca ttgtccacat ttggattcag ttggtgaaat      360

aacaaaagaa gatttgatac aaaaatccct tggtacttgt caggattgta aagtccaagg      420

accaaatctt tgggcatgtc tggagaatag atgttcatat gttggctgtg gtgaatcaca      480

agtagatcac agcaccatac attctcagga gacaaagcat tatctaactg tgaaccttac      540

cactcttcg                                                              549


<210> 4106
<211> 1233
<212> DNA
<213> Homo sapiens

<400> 4106
ccgagaattc gtgggtgctc aagaggatgg gtgtggcctg gcagcgcagg cgcactagag       60

gcctgtaggg tcggggcgcc tgcgcagtcg ctcttcctca ggcggcggcc atggcgggac      120

aggaggatcc ggtgcagcgg gagattcacc aggactgggc taaccgggag tacattgaga      180

taatcaccag cagcatcaag aaaatcgcag actttctcaa ctcgttcgat atgtcttgtc      240

gttcaagact tgcaacacta aacgagaaat tgacagccct tgaacggaga atagagtaca      300

ttgaagctcg ggtgacaaaa ggtgagacac tcacctagaa cagtgccgtg ctgctgctgg      360

gaagttgctt tacacaacac aggccacatg ggaaaggccc cagcagcctt cagctccttc      420

ctttctcctt aaagagcaac agggcttatt cttgtttttc ttttttcaaa agtgtggcct      480

ttgggctctg ccatctgggg tgtggtgtgg tatgtgggaa gaagttcaga ggaaccgttg      540

gaaacgacgt taggcatttt accttttcag taacatttta tacatctact tgtcaatgta      600

tttgagacat tcacagccaa aagcctggga ctctttgtga aggtcctcct cacctctatc      660

tttctttctc tctctctcaa actttcctta aagttctcat tgcctttgca ctgcttctgt      720

gaacagtctt tgtctcctcc ccacctttgg tgggaagtgc ggggcagtcc tggtcaagac      780

actcatgccc tggcaatgtg gctgccagag aatgttgttg ctaacccacc agtttcttgt      840

tgatttggag aggtcaaggc caggccccca cttggcttga agggacattt tcagactttt      900

ctttctgtca cttggagtgt ctatgcctct catatttccc taataaactc ctcaactttt      960

tatctgactg ctgtgattat ggtggggaga ggagctagag atgggttcac ttattgcaca     1020

gaaatgtaat acatggcgtt attattctaa cataaaactt tcagatgtag ctgtttgatt     1080

caaagcctag gtggcttacc agcccaagtc cccatgtttg gactttcagc tgactagctc     1140

atcttgggaa tcatttggtc attcagcaca tttaccaagt atttactatg taggcatgtt     1200

aaactccaat aaaacataca gcattgaatc aga                                  1233


<210> 4107
<211> 637
<212> DNA
<213> Homo sapiens

<400> 4107
ccaccgaggt cgcacgcgtg agacttctcc gccgcctccg ccgcagacgc cgccgcgtga       60

gtgtggtgac cgggcccggg gtgccggctg gggacgcgga gtccgtgggg atgcggggtg      120

ggcggcgggg tatttttggg acggaggcct acgggccgag ccacgcgcgg cctcgcccgg      180

cggccccggg atgggccggc aggaggccgc cggggtaact ccgccgtcgc gtcctctccg      240

cccgcctcag gatgcgctac gtcgcctcct acctgctggc tgccctaggg ggcaactcct      300

cccccagcgc caaggacatc aagaagatct tggacagcgt gggtatcgag gcggacgacg      360

accggctcaa caaggttatc agtgagctga atggaaaaaa cattgaagac gtcattgccc      420

agggtattgg caagcttgcc agtgtacctg ctggtggggc tgtagccgtc tctgctgccc      480

caggctctgc agcccctgct gctggttctg cccctgctgc agcagaggag aagaaagatg      540

agaagaagga ggagtctgaa gagtcagatg atgacatggg atttggcctt tttgattaaa      600

ttcctgctcc cctgcaaata aagccttttt acacatc                               637


<210> 4108
<211> 1362
<212> DNA
<213> Homo sapiens

<400> 4108
accacaaagc ggttggttgc ggcagggact acaccggtgt atcatgggag cggcccgggc       60

tacacgttaa aaacactaag gggagcgcgc gaagctgaac ttggcgctcg atgggggccg      120

ttagccgccc tagagcgcgc ggagccgcag aggcgtagct ggactacaac gcagtgcatc      180

tcgggaggcc aactcgactg gactggcccc ctcatgcccg gctgcgagct gcccgtgggc      240

acctgcccgg acatgtgccc ggccgccgag cgcgcccagc gcgaaaggga gcaccgcctg      300

caccgcttgg aggtggtgcc gggttgccgc caggacccgc cccgcgcgga tccgcagcgc      360

gcggtgaagg agtacagccg acccgccgcc ggcaagcccc ggcccccgcc cagccagttg      420

cgtccgccct ccgtgctgct ggccaccgtg cgctacctgg ccggtgaggt ggcggagagc      480

gccgacatcg cccgcgccga ggtggccagc ttcgtggcag accgcttgcg agctgtgctc      540

ctggacctgg cgctgcaggg agcgggcgac gccgaggcag ctgtggtgct ggaggcggcg      600

ctggccacgc tgctgaccgt agtggcgcgg ctcgggcccg acgcggcgcg gggacccgcg      660

gacccggtgc tgctgcaggc ccaggtgcag gagggcttcg gctcgctgcg gcgctgctac      720

gcgcggggcg ccgggccgca cccccgccaa cccgccttcc agggcctctt tctgctctat      780

aacctgggct cggtggaagc cctgcatgag gttctacagc tgcctgctgc cctgcgcgcc      840

tgcccgcccc tccgcaaggc cttggcggta gatgctgcct tccgagaggg caatgctgcc      900

cgcctgttcc gtctgctcca gaccctgccc tacctgccaa gttgcgctgt gcagtgccat      960

gtgggccatg cccgccggga agccctggcc cgcttcgctc gtgcctttag cacccccaag     1020

ggccagacct tgcctctggg cttcatggtc aacctcttgg ccctggatgg actcagggaa     1080

gcacgggacc tgtgccaggc ccacgggctg cccttggacg gagaggagag agttgtgttc     1140

ctgaggggtc gctacgtgga ggaagggcta ccgcctgcca gtacgtgcaa ggtgttagtg     1200

gagagcaaac ttcgaggacg taccctggag gaggtggtca tggcagagga ggaagatgag     1260

ggcacggaca gacctgggtc cccagcctga ggagggagcg tgagcctccc agagccccag     1320

gactgggcca gagcacttag gtttcttttt ccatggtttc ca                        1362


<210> 4109
<211> 4415
<212> DNA
<213> Homo sapiens

<400> 4109
aaggtccctt taaggcgacg gcgccttcct cgggtcagac taccggcggc gacgaccaca       60

ggagcatggc ggacaccgac ctgttcatgg aatgtgagga ggaggagttg gagccatggc      120

agaaaatcag tgatgtcatt gaggactctg tagttgaaga ttataattca gtggataaaa      180

ctaccacagc tggcaatcct ttggtccagc aaggtggaca gccactcatc ctgacccaga      240

atccagcccc aggtctgggc acaatggtta ctcaaccagt attgaggcct gttcaggtca      300

tgcagaatgc caatcatgtg actagttccc ctgtggcctc acaaccaata tttatcacta      360

cgcagggatt tcctgtaagg aatgtccggc ctgtacaaaa tgcaatgaat caggttggga      420

ttgtgctgaa cgtacagcaa ggccaaacgg ttagaccaat tacactagtt ccagccccag      480

gtacccagtt tgttaagccg acagttggag ttccacaagt gttctcccag atgacccctg      540

tgaggccagg ctccacaatg cctgtgaggc ccaccaccaa caccttcacc accgtcatcc      600

cggccactct taccattcga agcaccgtcc cacagtccca gtcccagcag accaagtcca      660

ctcccagcac ttctaccact cccactgcca cacagccaac ctcactgggg caactagctg      720

ttcagtctcc aggccagtca aaccagacca cgaatcccaa gctagtgagc attgccagct      780

ttgtcactgt gaagcgacct ggtgttacag gcgaaaatag caatgaagtg gccaaattgg      840

tgaataccct taacaccatc ccttccctgg gccagagtcc tgggccagtg gtggtgtcca      900

acaacagctc tgctcatggc tctcaaagaa ccagcggacc tgagtcttca atgaaagtga      960

cctcttccat cccagtattt gacctccagg atggtggacg gaaaatatgt ccacgatgta     1020

atgctcaatt tcgtgttact gaagctttga gaggtcacat gtgttactgt tgcccagaaa     1080

tggttgaata ccagaagaaa ggaaagtccc tggattcaga acccagtgtc ccatcagcag     1140

caaagccccc atcccctgag aaaacagctc ctgttgcttc cacaccctct tctacaccta     1200

ttcctgctct gtcaccgcct accaaagtac cagaaccaaa tgagaacgtg ggcgatgccg     1260

tccagaccaa actcattatg cttgtagatg acttctacta tggacgggat ggtggcaaag     1320

tagcccagct cacaaatttc cctaaggtcg ccacatcttt ccgatgccca cattgtacca     1380

aaaggctaaa aaacaatatt cgattcatga accatatgaa acaccacgta gaactcgatc     1440

agcagaacgg tgaggtagat ggtcacacta tctgccagca ctgttaccgc cagttttcca     1500

ctcccttcca gcttcagtgc cacttggaaa atgttcatag tccctatgaa tctactacca     1560

agtgcaagat ctgtgaatgg gcgtttgaaa gtgagccact atttctccag catatgaagg     1620

atactcataa gcctggagag atgccttatg tttgccaggt gtgtcaatat cgctcctcac     1680

tctactctga ggtagatgtc cattttcgga tgatccatga ggatacccgg catctgctct     1740

gcccttattg cctgaaggtc ttcaaaaatg gcaatgcatt ccaacagcat tacatgaggc     1800

accagaagag aaatgtttat cactgcaaca aatgccggct gcagtttctc tttgccaagg     1860

acaaaattga acacaagctt caacaccata aaaccttccg taaacccaag cagctggagg     1920

gcttgaaacc aggcaccaag gtgacaatcc gggcttcccg agggcagcca cgaactgttc     1980

ctgtatcctc taatgataca cctcccagcg ccttgcagga ggcagcaccg ctgacctcct     2040

caatggaccc tctgcctgtc ttcctttatc cccctgtcca gcgcagcatc cagaagagag     2100

ctgttaggaa aatgagtgtc atgggccggc agacatgcct ggagtgcagc ttcgagatcc     2160

cagacttccc taatcatttc cctacttacg tacactgctc tctgtgtcgc tatagcacct     2220

gctgttctcg agcttatgcc aaccacatga tcaacaatca tgttccacgg aagagcccca     2280

agtatttggc tttgtttaaa aattctgtga gtggaatcaa gctggcctgc acttcatgta     2340

cctttgttac ctctgtgggc gatgctatgg ccaagcattt ggtattcaac ccctctcaca     2400

gatccagcag catcctgcca cggggactca cttggatagc tcactcaagg catggccaga     2460

ctcgtgaccg agtgcatgac cggaacgtga agaatatgta ccctcctcct tccttcccca     2520

ctaacaaagc tgccactgtg aaatctgcgg gggccacccc agctgagcct gaagagctac     2580

taactccctt agccccagca ctcccatcac cagcctcaac tgcaacccca ccaccaaccc     2640

ccactcaccc gcaggcttta gcccttccac cgctggctac agagggagcc gaatgtctga     2700

atgttgatga tcaggatgaa gggagcccag tcacccaaga acctgagcta gcatcaggtg     2760

gtggtggtag tggtggagtt ggcaaaaagg agcagctgtc tgtgaagaag cttcgagtag     2820

tactgtttgc tctatgctgc aatacagaac aggcagctga acacttccga aatccccagc     2880

gacgtattcg ccgttggctt cgacgtttcc aggcctccca gggggagaat ctagagggca     2940

aatatctgag ctttgaggca gaagagaaac tggctgagtg ggtgctaacc cagcgcgaac     3000

aacagctacc tgtaaatgag gagaccttgt tccagaaggc caccaaaata ggacgttctt     3060

tggaaggggg gtttaagatc tcctatgagt gggctgtgcg tttcatgctg cggcaccacc     3120

tgactcccca tgcccggcga gctgtggccc acaccctacc taaggatgta gcagagaatg     3180

caggactctt cattgatttt gtacaacggc agattcacaa ccaggactta cccttgtcta     3240

tgattgtggc tattgatgag atctctttgt tcctggatac agaggtgctg agcagtgatg     3300

atcgaaagga gaatgccctg cagacagtgg gcacagggga accttggtgt gatgtagtcc     3360

tagccattct ggcagatggc actgtccttc ccaccctggt tttctacaga gggcagatgg     3420

atcagcctgc taacatgcca gactccatat tgctagaggc aaaggagagt ggctacagtg     3480

atgacgagat catggagctg tggtcaactc gagtgtggca gaagcacaca gcttgccagc     3540

gcagcaaagg catgcttgtg atggactgtc atcgcactca cttgtcagaa gaggtactgg     3600

ctatgcttag tgcctctagc actttgcctg cagtggtccc agcaggctgt agctccaaaa     3660

ttcagccatt agatgtatgc atcaaaagaa ctgtcaagaa cttcctgcat aaaaaatgga     3720

aggaacaggc tcgggaaatg gcagatactg catgtgattc tgatgtcctg cttcagctgg     3780

tgcttgtctg gctgggtgaa gtgctaggtg tcattgggga ctgtccagag ctagttcagc     3840

gctccttcct ggtggctagt gttctgcctg gccccgatgg caacattaac tcacctacaa     3900

gaaatgctga catgcaggag gagctaattg cctccctaga ggagcaactg aagctgagtg     3960

gggaacattc tgagtcttcc actccacgac ccagatcatc tcctgaagag acaattgagc     4020

ctgaaagtct tcaccagctc tttgagggtg aaagtgagac cgagtctttc tatggctttg     4080

aagaagctga cctagatctg atggagattt gagtgttggg gtcatgaggg ggtgtggagt     4140

gagggtggga acatgtgagg gagggtaaag gggcttaggg aaaagggggc ataccaggtg     4200

gggtatttgg tttctatttt ttaattttat accaccactc ccccctgaag ttgacttaca     4260

cttccctgtg gatttgtgga ttaattagga aaaccaatag taatcacgtc tgagccaagg     4320

agctggccca ttggtcattc acttctgcta aaaacaggtt tttgtgactt tttttttttt     4380

taaatttaaa tcactgtgtt tggtattttt ctgac                                4415


<210> 4110
<211> 687
<212> DNA
<213> Homo sapiens

<400> 4110
agagctttgt gctgaacatc agtcctccac atcgactcct cttgtaagat gttgtgtcca       60

ggtggatcat cacagtggct gccatcctta aatatgtctt ggtcctgttg ctgctaattg      120

ataccagcat gttttggaaa tttgatcttc actcatcatc ccacatagac acacttctag      180

aaagagaaga tgtaacactg aaggagttaa tggatgagga agatgtttta caggaatgta      240

aagctcagaa ccgcaaactt atagagtttc tgttaaaagc agaatgtctc gaagatttag      300

tctcattcat tatagaagaa ccacctcaag acatggatga aaagatcaga tacaagtatc      360

caaatatatc ttgtgagttg ctcacttctg atgtctccca gatgaatgat agactgggag      420

aagatgaatc cttgctaatg aaattatata gcttcctcct aaacgattcc cctttgaatc      480

cactacttgc cagtttcttc agcaaggtgc taagtattct tatcagcaga aaaccagaac      540

agattgtgga tttcttaaag aagaagcatg attttgtaga ccttattata aagcacatag      600

gaacttctgc tatcatggat ttgttgctca ggctcctgac gtgtatcgaa cctccacagc      660

ccaggcaaga tgtgctgaat tggttaa                                          687


<210> 4111
<211> 582
<212> DNA
<213> Homo sapiens

<400> 4111
gctctggggc ttggtggggg caatccctgc gtccggagag cgctggtggt agggaggctt       60

ctcccggttc tgtgagcagc aggaccctcc cgagggcctg accgtggagg tagcactgca      120

cacccactcc ctgtgggccg gagccaggag gcacttcctg ggtgtcggag cccagaagga      180

aaccagtggc cgggaagcac cagctgggtc agtctccagg tgtgggacag gcactggcct      240

cagaccgggg ccacactgag gtctgccctt ctcccgctgg ccgccaccca agacaccatg      300

agccagtccg gggccgtgag ctgctgcccg ggtgccacca atggcagcct gggccggtcc      360

gacggtgtgg ccaagatgag ccccaaggac ctgtttgagc agaggaagaa gtattccaac      420

tccaacgtca tcatgcacga gacctcgcag taccacgtcc agcacctggc cacattcatc      480

atggacaaga gcgaagccat cacgtctgtg gacgacgcca tccggaagct ggtgcagctg      540

agctccaagg agaagatctg gacccaggag atgctgctgc ag                         582


<210> 4112
<211> 2294
<212> DNA
<213> Homo sapiens

<400> 4112
tggcgcatat ggtattctaa atattactgg aagtaacagg gatgctctgt agatccccaa       60

caatactttt gagaagcagt tgctgatata tttttccatt cagtggaaac ctatccgagc      120

aaatttcatg gttgcactga tctcttaaca atatgtatta ccatgcttct ccactaaaat      180

atgtctgtaa ggaagtaccc agtacagtat gtctgtaagg aatattccat taaaaggaat      240

atagtgtcgc tgtcaattac attttttttt cttttgagat ggagtcttgc tctgttgcca      300

ggctggagtg caatggtgca atctcggctc tcccgagtag ctgggactac aggtgtgcgc      360

caccacgccc agctgatttt tgtattttta gtagagatgg ggtttcacca tgttggcgag      420

atggtctcca tctcttgacc tcgtgatcca cccacctcgg cctcccaaag tgctggtatt      480

acaggcgtga gccatcacgc ctggcctatt tacatatttt cattaaactc aattttcaga      540

gtcattttca gagcacatgg atgatagcaa gcaagaatct accaccagta aagaagagga      600

aacaaatatt ataagttcca tagttccttc aacacaagat atttatcagc ggcagaactc      660

ttcagacgtt cataaatctc tgttgcctgc agtggatgaa actacatgtg gtcacacaca      720

ctttcagcaa atgatagaca agtacattaa tgaagcaaat ttgatacctg aaaaaacaga      780

tttgcaagaa ttggaacaca tttttcctaa tttgcatcat cagctgttta aacccttaga      840

accacatcca gattttgact tatcatcatc atcctctggg atttctccag acaacagaga      900

cttttaccag agatcagatt cttcatctga aagccactgt gctactggat tatccaaaag      960

tacagtttat ttcacagcac tgaggaggac cagcatgcat tcttctctta acacaagtcc     1020

gaatcaacaa cctgacacta acttggctca tgttggagct cacagttttg ctacagaaaa     1080

tattattggg ggatctgaac aatgttttga acagcttcag ccagaatatt cttcacagga     1140

ggagagccag catgctgatc taccaagtat ttttagcatt gaagcaagag attcttccca     1200

aggcatgaaa aatcagaact atccctctga agaacatact gaaatattac aaaacaagaa     1260

aaaaattgtt catttccagc tttctatagg aaacttaagt tcagtctaca gttcatctga     1320

tgaagctaat gtatttgatc agttaaatgt acagcatagc actccatgtg gttctaactc     1380

tagtgagtgc tcaacaaaac accaactaga aagcagaaag gaaagtatgg gctttgaaga     1440

actatcaaaa agaggggttg ttacaatgtt acaaagtcaa ggactcattg aagataataa     1500

aaatgaaacc tgtagggttt tagacataaa tccacaggta gaggaaactg actctcgatt     1560

atgtgtaaga acagtggaga tgggaacttc aattcaggca ccatattcct taactactca     1620

aaatgaaaaa tattttgaga attcagctga aacagacatt ccaaaaatca ccaaaaaact     1680

atctcaacta ggagaatcag agctttttgc aagttctgga tcattttcat tacagagctc     1740

tataccagtc tgggaaacag aaactggcca tggtataatg gaagaaccag aacttacttt     1800

aataagcacc actgatacca gtattgctga aatggatttt gcaaatttaa ccctagaaga     1860

gaagagcgag aatgaagcaa aatgcttctt tcaggtgagt gagtttctgc ctcttgtatc     1920

agcaacagaa gcctcagatt atccagctgt atcagaactt tccatagaaa aaccaaggac     1980

agcatctaca gcagaaaccc ctcgcaggct tacacctgta ccagggagct tacaagaagc     2040

atttataaag aggaaaaaat catttatgga gagatcccac cagaggcaga aagaaataag     2100

gaataaaatt catgtctctg aaaattctca aatcaaaaca gttaaagaga aaccatctat     2160

aagttcatct gtgagtcgtc taaagggcgt gaataaagtc agagcatctt ttcctgaaga     2220

cagaaagact acacaggctc taaggcacca aaggggtcta aggttataca atcaactagc     2280

tgaagtgaaa caac                                                       2294


<210> 4113
<211> 578
<212> DNA
<213> Homo sapiens

<400> 4113
ctttctgtgg tgaggattag cggcagcaag gaatgcagtg gagccattac cttgtcacct       60

tctgagcagg gttaggcttg ctgaggggca ggcacaggag tcctggctga gctcatggcc      120

tgaggctgcc tagcggccac ggggaatggt tgcaatggcg gaggcagagg caggggtggc      180

agtggaggtc cgtggactgc cccctgccgt gcccgacgag ctgctcactc tctactttga      240

aaaccgccga cgctctggag ggggacctgt gttgagctgg cagagactgg gctgtggggg      300

cgtcctcacc ttcagagagc ctgcagacgc cgagagggtc ttggcccagg cagatcacga      360

actacatggt gcccagctga gcctgcggcc agctccacca cgagcccctg cacgcctgct      420

gctccaagga ctgccccctg gcaccacgcc ccagcgcttg gagcagcatg tccaggcctt      480

gctgcgggcc tcggggctcc cagtacagcc ttgctgtgcc ttggccagcc cccggccaga      540

ccgggctctg gtccagttgc ccaagcccct ttctgagg                              578


<210> 4114
<211> 500
<212> DNA
<213> Homo sapiens

<400> 4114
atgctcagca cctggcaggt gtgagggacc aggagcaggg ttgagaaggt tgctgggggc       60

gttgaaggcc agccttggcc gggggcgggc ctggagaccc agcactttgt gtgcagaggg      120

tgtcatggac acagaggctt ggagatcctg agtgaggggc agtgactcag gccccttgca      180

gggttaggct tgctgagggg caggcacagg agtcctggct gagctcatgg cctgaggctg      240

cctagcggcc acggggaatg gttgcaatgg cggaggcaga ggcaggggtg gcagtggagg      300

tccgtggact gccccctgcc gtgcccgacg agctgctcac tctctacttt gaaaaccgcc      360

gacgctctgg agggggacct gtgttgagct ggcagagact gggctgtggg ggcgtcctca      420

ccttcagaga gcctgcagac gccgagaggg tcttggccca ggcagatcac gaactacatg      480

gtgcccagct gagcctgcgg                                                  500


<210> 4115
<211> 3044
<212> DNA
<213> Homo sapiens

<400> 4115
gtctgtttaa ggaatagcag aagacatgac atgtagacaa atttcaggtt attttcagaa       60

gatactgggt ttgttactgt attttaaaag gatactttct tggtttgtta tgagatattc      120

taattaaaca gtgatgaatt cttactcctg gtcagtgtaa gtctaaattc aagtttgttg      180

ctttgtttta cagtttcctt tcactcccct cccccatccc ctcatgagtc ataagcatgc      240

agtgttggga atagaacttg tcagctgagt ggggatgaga cagttctctg cccatactat      300

ttgtaactgt agtcaatgag gagaggaaag gacgttatta aatgctggag aaacaccttg      360

attgaggcag cttcttctgt ggctgtgtgg tatggatgca gagttctgtg tgactataca      420

ctgatgtatt ctggctctga atcacttagg gatctcttct gcaccttgtg cattgtaggt      480

tttggatgct tatttgttta gggtctagga cctggtgctt agcctctcct ggatcctgta      540

tatttactga ctttccaaat tcttttgagt gtggcattat atctgcttca tcttctcttt      600

cttggctatt cttagtgccc ttctcatttt actgtcctaa tgttttccca tttatactat      660

gaatcattgt gcaccctatg tagagcctgt cattggagat taaaatcagt ggcagctctt      720

tgattttaca gctcagcctc agctgaacat aacttctttt tttcaaagtt ccctgtgttg      780

tgaactgagc ttgggtgaag tgaaatcttt gaggaagcta aagctgtgtg tatttgtgga      840

tcagacaagt gcagcaagtt aatatcattg gcttctgaag gggagagtga ggtgatggct      900

gcgtttaagt tggatttcct tccagaaatg atggtggatc attgctcttt gaattccagt      960

cccgtctcaa agaaaatgaa cggcaccctg gaccacccag accaaccaga tcttgatgct     1020

atcaagatgt ttgtgggcca ggttccaagg acctggtctg aaaaggactt gcgggaactc     1080

ttcgaacagt atggtgctgt gtatgaaatc aacgtcctaa gggataggag ccaaaacccg     1140

cctcagagca aagggtgctg ttttgttaca ttttacaccc gtaaagctgc attagaagct     1200

cagaatgctc ttcacaacat gaaagtcctc ccagggatgc atcaccctat acagatgaaa     1260

cctgctgaca gtgagaagaa caatgtggaa gacaggaagc tgtttattgg tatgatttcc     1320

aagaagtgca ctgaaaatga catccgagtc atgttctctt cgtttggaca gattgaagaa     1380

tgccggatat tgcggggacc tgatggcctg agccgaggtt gtgcatttgt gacttttaca     1440

acaagagcca tggcacagac ggctatcaag gcaatgcacc aagcacagac catggagggt     1500

tgctcatcac ccatggtggt aaaatttgct gatacacaga aggacaaaga acagaagaga     1560

atggcccagc agctccagca gcagatgcag caaatcagcg cagcatctgt gtggggaaac     1620

cttgctggtc taaatactct tggaccccag tatttagcac tttatttgca gctccttcag     1680

cagactgcct cctctgggaa cctcaacacc ctgagcagcc tccacccaat gggagggttg     1740

aatgcaatgc agttacagaa tttggctgca ctagctgctg cagctagtgc agctcagaac     1800

acaccaagtg gtaccaatgc tctcactaca tccagcagtc ccctcagcgt gctcactagt     1860

tcagggtcct cacctagctc tagcagcagt aattctgtca accccatagc ctcacttgga     1920

gccctgcaga cattagctgg agcaacggct ggcctcaatg ttggctcttt ggcaggaatg     1980

gctgctttaa atggtggcct gggcagcagt ggcctttcca atggcaccgg gagcaccatg     2040

gaggccctca ctcaggccta ctcgggtatc cagcaatatg ctgctgctgc gctccccact     2100

ctgtacaacc agaatcttct gacacagcag agtattggtg ctgctggaag ccagaaggaa     2160

ggtccagagg gagccaacct gttcatctac cacctgcccc aggagtttgg tgatcaggac     2220

ctgctgcaga tgtttatgcc ctttgggaat gtcgtgtctg ccaaggtttt catagacaag     2280

cagacaaacc tgagcaagtg ttttggtttt gtaagttacg acaatcctgt ttcggcccaa     2340

gctgccatcc agtccatgaa cggctttcag attggcatga agcggcttaa agtgcagctc     2400

aaacgttcga agaatgacag caagccctac tgagcgtgct cccctctgag actggagtga     2460

gagggtcttc tggtcttact tcagctcttg cctgtgaccc acacagcttc tgggctctgc     2520

ctctgctcta agaagtgctg tgggggtaga gaaccaggaa ggacatgctg ttgggaatgt     2580

acacctgggc agaggtggcc ctgttaagat gtgactgtag ccacagccag ggatgggatc     2640

cctgggtctc tggaatctga aacctcaaca aataccagtc ttgaccccta gcagcagaga     2700

taagaataaa ggggttggtt tgctattaag tcagatgggg gctctctcct tgtcatgctg     2760

tccctgtggg taacagacag ggattgacca tcttactgtt gtacaggtag ctggtggtgt     2820

tggattatcc cattgaagct gggacagctg ttcctttctc atagtgataa cttgggtctg     2880

ttgtcctcta aggaacgtga aacatacact tcttaagctg aaccacgtaa acttgaaatt     2940

ctgcgcactg ggagaaatgt gtcctgtgtt tcaaaggata aaactgttct aaaggcttcc     3000

agggtcatga tgggattttt taaataaatg caaaaaataa aaat                      3044


<210> 4116
<211> 1991
<212> DNA
<213> Homo sapiens

<400> 4116
agtctggtgt ctcatctctc gccccggagg tcaaacctgg agccagcatt tctgtaccct       60

gcgctcacac ctttttcaac ccggatggcg gtgatagtta atactttctg agcgctttta      120

ctatggtcag gcattatatt tacacctaat cctcgcaaaa cactactggg aagatcctca      180

tttgacagga gcaattccgg gtcacaaagg ctgacaccac aaagctagtc cgtagcgggt      240

tcgaccacag gcgcccacac tctttgacgc ctcaatggca cagccaagtg cgcgggaagt      300

gggctgcaaa cgccggagag ttttgtccgg agcgcagaga cgcgctgtaa ccgagcaacc      360

agcggggccc gcccccggcc tgctacggcg ctcccagcct gccccgcgcc gctcggcgcc      420

ggaagtgagt gagcatttcc ggcagccatc cccgcggtgc tgacatcccg gttgttcttc      480

tgtgccgggg gtcttcctgc tgtcatgaag gacgtaccgg gcttcctaca gcagagccag      540

aactccgggc ccgggcagcc cgctgtgtgg caccgtctgg aggagctcta cacgaagaag      600

ttgtggcatc agctgacact tcaggtgctt gattttgtgc aggatccgtg ctttgcccaa      660

ggagatggtc tcattaagct ttatgaaaac tttatcagtg aatttgaaca cagggtgaac      720

cctttgtccc tcgtggaaat cattcttcat gtagttagac agatgactga tcctaatgtg      780

gctcttactt ttctggaaaa gactcgtgag aaggtgaaaa gtagtgatga ggcagtgatc      840

ctgtgtaaaa cagcaattgg agctctaaaa ttaaacatcg gggacctaca ggttacaaag      900

gaaacaattg aagatgttga agaaatgctc aacaaccttc ctggtgtgac atcggttcac      960

agtcgtttct atgatctctc cagtaaatac tatcaaacaa tcggaaacca cgcgtcctac     1020

tacaaagatg ctctgcggtt tttgggctgt gttgacatca aggatctacc agtgtctgag     1080

cagcaggaga gagccttcac gctggggcta gcaggacttc tcggcgaggg agtttttaac     1140

tttggagaac tcctcatgca ccctgtgctg gagtccctga ggaatactga ccggcagtgg     1200

ctgattgaca ccctctatgc cttcaacagt ggcaacgtag agcggttcca gactctgaag     1260

actgcctggg gccagcagcc tgatttagca gctaatgaag cccagcttct gaggaaaatt     1320

cagttgttgt gcctcatgga gatgactttc acacgacctg ccaatcacag acaactcact     1380

tttgaagaaa ttgccaaaag tgctaaaatc acagtgaatg aggtggagct tctggtgatg     1440

aaggcccttt cggtggggct ggtgaaaggc agtatagacg aggtggacaa acgagtccac     1500

atgacctggg tgcagccccg agtgttggat ttgcaacaga tcaagggaat gaaggaccgc     1560

ctggagttct ggtgcacgga tgtgaagagc atggagatgc tggtggagca ccaggcccat     1620

gacatcctca cctagggccc cctggttccc cgtcgtgtct cctttgactc acctgagaga     1680

ggcgtttgca gccaatgaag ctggctgctc agacggtcga cattgaattt gggtgggggt     1740

tgggatcctg tctgaagtac agactgttct tgctctaaaa acaggactgt ccctgatggg     1800

agccaggcca cagggaggag gcttctttgt gggtctctcc tgcagagggt gggggtctca     1860

gggtcttagg tgatacggga gagaaagaac gtgccaggca ggaggccccc tgaagtctgt     1920

gtactccgag gtggatctcc atccccatcc acctgtacgg acatcttttc cgttgcggtt     1980

tgagaatgtt c                                                          1991


<210> 4117
<211> 805
<212> DNA
<213> Homo sapiens

<400> 4117
ctttccgcca gcgcccgcag gacccggatg agagcgcacg cttcggggtc tccgggaagt       60

cgcggcgcct tcggatgtgg cggatgcggc cgtgagccgg cgggggagtt cctccagatc      120

cagctggtgc cctcgcctga cgtttgaacg accacctgct cacctcctcc cttttgcgcg      180

ttgattcttc agacttcaaa gggcccaccg gtgctgctgc tgcctccact gtactcagac      240

ccaggtagca caggattgtc catcctccag cagctcagtg caacggtgtg aactcagcct      300

gtttcagagc ctccacacca tgacctccaa gaagctggtg aactcggtgg ctggctgtgc      360

tgatgacgct cttgctggcc tggtggcctg caaccccaac ctgcagctcc tgcagggcca      420

ccgcgtggcc ctccgttctg acctggacag cctcaagggc cgggtggcac tgctgtcggg      480

tgggggctct ggccatgagc ctgcccatgc tggtttcata gggaagggga tgctgactgg      540

ggtcatcgcg ggagctgtgt tcacctcccc ggcagtgggc agcatcctgg cagccatcag      600

ggccgtggcc caggccggca cagtggggac gctccttatc gtgaagaact acactgggga      660

tcggctcaac ttcggcctgg cccgggagca ggcccgggct gaaggcatcc cggtggagat      720

ggtggtgatt ggggacgaca gcgccttcac tgtcctgaag aaggcaggcc ggcgggggct      780

gtgcggcacg gtgcttatac acaag                                            805


<210> 4118
<211> 8246
<212> DNA
<213> Homo sapiens

<400> 4118
gatcagcggc ggcggtgacc gcgagtgggt cggcaccgtc tccggctccg ggtgcgaaca       60

atgctgactg atagcggagg cggcggcacc tcctttgagg aggacctgga ctctgtggct      120

ccgcgatccg ccccagctgg ggcctcggag ccgcctccgc cgggaggggt cggtctgggg      180

atccgcaccg tgaggctctt tggggaggcc gggccagcgt cgggagtcgg cagcagcggc      240

ggcggcggca gcggcagcgg tacgggcgga ggggacgcgg cgctggattt caagttggcg      300

gctgccgtgc tgaggaccgg gggtggaggt ggtgcctctg gcagtgacga ggacgaagtg      360

tccgaggttg aatcatttat tttggaccaa gaagatctgg ataacccagt gcttaaaaca      420

acatcagaga tattcttatc aagtactgca gaaggagcag acttacgcac tgtggatcca      480

gagacacagg cacgactaga agcattgcta gaagcagcag gaattggcaa attgtcaact      540

gctgatggta aagcttttgc agatcctgag gtactccgga gactgacatc ctcagttagt      600

tgtgcactgg atgaagctgc tgctgcactg acacggatga aagcagaaaa cagccacaat      660

gcaggacaag tggacactcg cagtctagca gaagcttgtt cagatgggga tgttaatgct      720

gttcgtaaat tgctagatga aggcagaagt gtaaatgaac atacagaaga aggagaaagc      780

ctgctgtgtt tggcttgttc agcagggtat tatgaattag cacaagtatt gcttgctatg      840

catgctaatg ttgaagatcg agggaataaa ggagacataa ctcccctgat ggcagcttcc      900

agtggaggtt acttagatat tgtgaaatta ttacttcttc atgatgctga tgtcaactcc      960

cagtctgcaa caggaaacac tgcgctaact tatgcatgtg ctggaggatt tgttgacatt     1020

gttaaagtgc tccttaatga aggtgcaaat atagaagatc ataatgaaaa tggacatact     1080

cccttaatgg aagcagccag tgcaggtcat gtggaagttg caagagttct tttagatcat     1140

ggtgcaggca tcaacactca ttctaatgaa ttcaaagaaa gtgctctaac acttgcttgc     1200

tacaaaggcc atttggatat ggttcgcttt ctacttgaag ctggtgcaga tcaagagcac     1260

aaaacagatg agatgcacac tgccttaatg gaggcctgca tggatggaca tgtagaggtg     1320

gcacgtttgc ttttggatag tggtgctcaa gtgaacatgc ctgcagattc atttgaatct     1380

ccattgacgc tagctgcctg tggaggacat gttgaattgg cagctctact tattgaaagg     1440

ggagcaaatc ttgaagaagt taatgatgaa ggatacactc ccttgatgga agctgcccgg     1500

gaaggacatg aagaaatggt ggcactactc ttagcacaag gagcaaatat aaatgcccag     1560

acagaagaaa ctcaagaaac tgctcttact ttggcttgct gtggaggatt ttctgaagtt     1620

gcagactttc ttattaaggc aggggctgat atagaacttg gctgctccac acctctgatg     1680

gaggcatctc aggagggaca cctggaattg gttaaatatt tgctggcttc tggcgctaat     1740

gtgcatgcta caacagcaac aggagacaca gccttaacct atgcttgtga aaatggacat     1800

acggatgttg cagatgtttt acttcaagca ggggctgatt tagaacatga atctgaaggt     1860

ggaagaacac ctttgatgaa agctgcaaga gctggtcatt tgtgcactgt gcagtttctt     1920

attagcaaag gtgccaatgt taacagggct acagccaata atgatcatac agtagtgtcg     1980

ctggcatgtg caggaggcca cctggcagtt gttgagcttc tcttggctca tggggctgac     2040

cctactcatc gactcaagga tggttcaaca atgctcattg aagctgcaaa gggtggccat     2100

actaatgtag tttcttatct gttggattat ccaaataatg ttctgtcagt tcccaccaca     2160

gatgtgtctc agctccctcc accttctcaa gatcagtctc aggtgccacg tgtgccaacg     2220

catacacttg ccatggttgt acctccccag gaacctgaca gaacttcaca ggagaactct     2280

cctgcccttt taggagtgca aaaaggtaca tccaagcaga agtccagttc cctccaggta     2340

gcagatcagg acctactgcc atcttttcac ccataccagc ctttggagtg catagtagag     2400

gagactgaag gcaagctgaa tgaactggga caaagaatta gtgctattga aaaagcacag     2460

cttaagtcac tggagttaat tcaaggtgaa cctctgaaca aagataagat agaagaactt     2520

aaaaagaaca gagaagagca agtccagaag aagaagaaaa tattgaaaga actgcagaaa     2580

gtggaaaggc agttgcagat gaaaacacag cagcaattta ccaaagaata cttggaaacc     2640

aaaggtcaga aagacacagt gtctctacac caacagtgct ctcatagagg agtcttccca     2700

gaaggggaag gagatggtag tctcccagag gatcactttt cagagttacc tcaggttgac     2760

acaatcttat ttaaagataa tgatgttgat gatgagcaac agtctccacc atcggcagaa     2820

cagattgatt ttgtcccagt ccagccttta tcatctccac agtgtaactt ttccagtgac     2880

ttaggttcta atgggacaaa ttctcttgaa cttcagaaag tatcaggtaa tcagcagatt     2940

gtaggacagc ctcagattgc tattactgga catgatcagg ggctgttagt tcaagaacca     3000

gatggactaa tggttgcaac tccagctcag acgcttaccg acactcttga tgacctgata     3060

gcagctgtga gtaccagagt gcccactggt tccaacagtt cttctcagac cacagagtgt     3120

cttacacctg aatcctgttc gcagactaca agcaatgtgg cttcccaatc gatgcctcct     3180

gtgtatcctt cagttgacat tgatgcacat actgagagca atcatgacac agcattaaca     3240

ctagcttgtg caggtggtca tgaagaactt gtatctgtgc tcattgcacg ggatgccaaa     3300

attgaacaca gagacaaaaa aggtttcaca ccactaatcc tggcagcaac agcagggcat     3360

gttggagttg ttgaaatcct tttggataaa ggtggagata tagaagcaca gtctgaacga     3420

actaaggata ctccgctttc attggcatgt tctggtggac gtcaggaggt ggtagacttg     3480

ctgctggctc gaggtgcaaa taaagaacat aggaacgtat ctgattatac accactgagt     3540

ctagctgcgt ctggaggata tgttaatatc attaagattc tgcttaatgc tggggcagaa     3600

attaattcaa ggactgggag taaactaggt atttctcccc tgatgttggc tgcaatgaat     3660

ggacatgttc ctgcagtaaa attgctgctc gatatgggtt cagacattaa tgcccaaata     3720

gagaccaatc ggaacacggc tctcaccctg gcctgtttcc agggccgagc agaagtagtg     3780

agtttgcttc tggaccgaaa agccaatgtt gaacataggg caaagacggg tcttaccccc     3840

ttgatggaag cagcttctgg agggtatgca gaggttggaa gagttcttct tgataaagga     3900

gcagatgtta atgctccccc tgtgccttcc tcaagagata ctgctttaac aatagcagca     3960

gacaaaggtc actacaaatt ttgtgaactc ctgattcata ggggagccca cattgatgtt     4020

cgtaacaaaa agggaaatac gccactttgg ctggcatcca atggaggtca ttttgatgtt     4080

gtgcagttgc tagtgcaagc aggtgctgat gtggatgcag cagataaccg gaaaatcaca     4140

cctcttatgt cagcatttcg caagggtcat gtaaaagttg ttcaatattt ggtaaaggaa     4200

gtaaatcagt tcccttctga tatagaatgc atgagataca tagcaacaat tacagataag     4260

gaactgttga aaaaatgtca tcaatgtgtc gaaaccattg tgaaggctaa agaccagcaa     4320

gctgcagaag caaataagaa tgcgagtatt cttttaaagg aacttgatct ggaaaagtca     4380

agagaagaga gcagaaagca ggctcttgct gctaaaagag aaaaaagaaa agaaaagaga     4440

aaaaagaaaa aagaggaaca gaaaaggaaa caggaagaag atgaagaaaa caaacctaag     4500

gagaattcgg aactaccaga ggatgaagat gaagaggaga atgatgaaga tgtggagcaa     4560

gaagttccca tagaacctcc tagtgcaacc accaccacta cgattggaat ctctgcaaca     4620

tctgcaacat tcacaaatgt gtttgggaaa aaaagggcca atgtggtgac aactcccagc     4680

accaatcgga aaaataagaa gaacaaaaca aaagaaaccc ctcctacagc acatttaatt     4740

ttaccagaac aacatatgtc tttagcccaa caaaaggcag ataaaaataa aataaatgga     4800

gaacctagag gtggtggtgc aggtgggaat agtgattcag ataacttgga cagcacagac     4860

tgcaacagtg agagtagcag tggtggtaaa agccaagagt taaattttgt gatggatgtg     4920

aattcctcta aatacccctc actgctcctt cattcccaag aagaaaagac aagtactgct     4980

acttccaaaa ctcagacacg acttgaaggt gaagtgactc ctaattcctt gtcaaccagc     5040

tacaagacag tgtcattgcc attaagctct ccaaacataa agctgaatct cactagccct     5100

aaaaggggtc agaaaagaga agaagggtgg aaagaagttg tacgaaggtc aaagaaattg     5160

tctgttccag cctcagtggt gtcgaggata atgggaagag gaggatgcaa catcactgca     5220

atacaggatg ttactggtgc ccatattgat gtggataaac aaaaagataa gaatggcgag     5280

agaatgatca caataagggg tggcacagaa tcaacaagat atgcagttca actaatcaat     5340

gcactcattc aagatcctgc taaggaactg gaagacttga ttcctaaaaa tcatatcaga     5400

acacctgcca gcaccaaatc aattcatgct aacttctcat ctggagtagg taccacagca     5460

gcttccagta aaaatgcatt tcctttgggt gctccaactc ttgtaacttc acaggcaaca     5520

acgttatcta cgttccagcc cgctaataaa cttaataaga atgttccaac aaatgtacgt     5580

tcttctttcc cagtttctct acccttagct tatcctcacc ctcattttgc cctgctggct     5640

gctcaaacta tgcaacagat tcggcatcct cgcttaccca tggcccagtt tggaggaacc     5700

ttctcacctt ctcctaacac atggggacca ttcccagtga gacctgtgaa tcctggcaac     5760

acaaatagct ctccaaagca taataacaca agccgtctac ctaaccagaa cgggactgtt     5820

ttaccctcag agtctgctgg actagctact gccagttgtc ctatcactgt ctcttctgta     5880

gttgctgcca gtcagcaact gtgtgtcact aatacccgga ctccttcatc agtcagaaag     5940

cagttgtttg cctgtgtgcc taagacaagt cctccagcaa cagtgatttc ttctgtgaca     6000

agcacttgta gttccctgcc ttctgtctcc tctgcaccta tcactagcgg gcaagctccc     6060

accacatttc tacctgcaag tacttctcaa gcacagcttt cttcacaaaa gatggagtct     6120

ttctctgctg tgccacccac caaagagaaa gtgtccacac aggaccagcc catggcaaac     6180

ctatgtaccc catcttcaac tgcaaacagt tgcagtagct ctgccagcaa caccccggga     6240

gctccagaaa ctcacccatc cagtagtccc actcctactt ccagtaacac acaagaggag     6300

gcacagccat ccagtgtgtc tgatttaagt cctatgtcaa tgccttttgc atctaactca     6360

gaacctgctc cattgacttt gacatcaccc agaatggttg ctgctgataa tcaggacacc     6420

agtaatttac ctcagttagc tgtaccagca cctcgagttt ctcatcgaat gcagcccaga     6480

ggttcttttt actccatggt accaaatgca actattcacc aggatcccca gtctattttt     6540

gttacgaatc cagttacttt aacaccacct caaggcccac cagctgcagt gcagctttct     6600

tcagctgtga acattatgaa tggttctcag atgcacataa acccagcaaa taagtctttg     6660

ccacctacat ttggcccagc cacacttttc aatcacttca gcagtctttt tgatagtagt     6720

caggtgccag ctaaccaggg ctggggagat ggtccactgt cctcacgagt tgctacagat     6780

gcctctttca ctgttcagtc agcgttcctg ggtaactcag tgcttggaca cttggaaaac     6840

atgcaccctg ataactcaaa ggcacctggc ttcagaccac cttcccagcg agtttctact     6900

agtccagttg ggttaccatc cattgaccca tcaggcagct ccccatcttc ctcttctgct     6960

cctctggcaa gtttttccgg cataccagga acaagggttt tcctgcaagg gccagctcct     7020

gttgggactc ctagtttcaa cagacaacat ttttctcccc atccttggac aagcgcctca     7080

aactcatcca cttctgcccc accaacgttg ggccaaccaa aaggagtcag tgccagtcaa     7140

gatcgaaaga tacctccccc aattggaaca gagagactgg cccgaattcg gcaaggaggg     7200

tctgttgcac aagccccggc ggggaccagt tttgtcgctc ccgttggaca cagtggaatc     7260

tggtcatttg gtgtcaatgc tgtgtcagaa ggcttatcag gttggtcgca atctgtgatg     7320

gggaaccatc caatgcatca acaattatca gacccaagca cattctccca acatcagcca     7380

atggagagag atgattctgg aatggtagcc ccctctaaca tttttcatca gcctatggca     7440

agtggttttg tggatttttc taaaggtctg ccaatttcca tgtatggagg caccataata     7500

ccctctcatc ctcagcttgc tgatgttcca ggaggccctc tgtttaatgg acttcacaat     7560

ccagatcctg cttggaaccc tatgataaaa gttatccaaa attcaactga atgcactgat     7620

gcccagcagg ccagtctgct tccttcagtc cctgctctca aaggggaaat cccatcacct     7680

cagctaacca gaccgaagaa gagaattgga cggccgatgg tggcctctcc taaccagagg     7740

caccaggatc atctacgacc gaaagttcct gctggagtgc aagaactcac ccattgcccg     7800

gacacccccc tgctgcctcc ctcagattcc cggggtcaca actcctccaa cagcccctct     7860

ctccaagctg gaggagctga aggagcagga gacagaggaa gagatacccg atgacgcaca     7920

atttgaaatg gacatctaat ccagtgcaga tgacctggca tgtggagtta cagagggatc     7980

cctcatgcca ctgctgccac cacctcttcc tggggcatcc aaaggccagc tggcctcatc     8040

taatctggaa gggagtgact tgttagttcc aggcctcctt tagttctgag gcagctagac     8100

cagggatagg agtgggcaac ttgccaagcc cttaactcta cttcctcttc agtctgtggt     8160

actcctccta accctaaacc ctctatgctc aggggctgga actggggaat ggagtaagtc     8220

accttctgac tgcttagtaa acattc                                          8246


<210> 4119
<211> 844
<212> DNA
<213> Homo sapiens

<400> 4119
gcggggcggc ggggcggccg gcggcggcca tgggagatat cccagccgtg ggcctcagct       60

cctggaaggc ttctccaggg aaagtgaccg aggcagtgaa agaggccatt gacgcagggt      120

accggcactt cgactgtgct tacttttacc acaatgagag ggaggttgga gcagggatcc      180

gttgcaagat caaggaaggc gctgtaagac gggaggatct gttcattgcc actaagctgt      240

ggtgcacctg ccataagaag tccttggtgg aaacagcatg cagaaagagt ctcaaggcct      300

tgaagctgaa ctatttggac ctctacctca tacactggcc catgggtttc aagcctcctc      360

atccagaatg gatcatgagc tgcagtgaac tttccttctg cctctcacat cctcgagtgc      420

aggacttgcc tctggacgag agcaacatgg ttattcccag tgacacggac ttcctggaca      480

cgtgggaggc catggaggac ctggtgatca ccgggctggt gaagaacatc ggggtgtcaa      540

acttcaacca tgaacagctt gagaggcttt tgaataagcc tgggttgagg ttcaagccac      600

taaccaacca gattttgatc cgatttcaaa tccagaggaa tgtgatagtg atccccggat      660

ctatcacccc aagtcacatt aaagagaata tccaggtgtt tgattttgaa ttaacacagc      720

acgatatgga taacatcctc agcctaaaca ggaatctccg actggccatg ttccccatgt      780

aaatatggct ccttcttttt aaaacagagg gaagaatata cagattgaat gattggtgtc      840

tgaa                                                                   844


<210> 4120
<211> 1124
<212> DNA
<213> Homo sapiens

<400> 4120
tgggtacgtg actccgcccc cgggccggtg caggccctga ggggcgccga gatgtgggag       60

ctgctggccg cggcgtgggc agttcagggg ctgggcggct gagggtgcaa atagctatgg      120

gcaacttggc ctcggccata aggaagatgt gctgttgccc cagcaactga atgacttctg      180

taaacccagg agtgtcagga ggatcacagg aggagggggc cactctgcag ttgtcacaga      240

tggaggagac ctctttgttt gtggcctgaa caaagatggg caactggggc ttggtcacac      300

agaggatatc ccatatttta ccccctgcaa atccctcttt ggctgtccca tccaacaggt      360

ggcctgtggc tgggatttta cgattatgct cacagaaaat ggtcaagttc tatcatgtgg      420

atccaactcc tttggccagt taggagttcc tcatggacct cgaagatgtg tggttcccca      480

ggccattgag ctccataaag agaaggttgt ttgtattgct gctggactga ggcatgcagt      540

agctgctaca gcgagtggca tcgtgttcca gtgggggact ggtttggcat catgtggacg      600

acggttgtgc cctgggcaga ctcttccatt gtttttcaca gcaaaggaac caagcagagt      660

gacaggtcta gagaattcta aagcaatgtg tgttcttgct ggctcagacc actcagcttc      720

attaacagat gcaggagagg tgtatgtttg gggaagcaac aagcatgggc aactggctaa      780

tgaggctgct ttccttcctg tgccccagaa aatagaagca cattgtttcc agaatgaaaa      840

ggtcactgcc atctggagtg gatggacaca cctggttgct cagacaggtc tcttgtggct      900

cagagcataa tttggcaata attgtatctc tgcaaggtaa gtattattat cccagttttg      960

ctgatgtgga aatggagttg cagagaaatt aagagatata ctcaagatca cagtgttcat     1020

gtgtcatgga gccatttttg aatcctgtga gagacttcag tgctgatgat cggatgacca     1080

gaccatcaaa ccatgctgga ggtgattttt taattaccat tctg                      1124


<210> 4121
<211> 889
<212> DNA
<213> Homo sapiens

<400> 4121
gtgactgtcg tgtccaatta cagaaaagcc tgaatcaaga gtatgcagcc aaaactacta       60

ccaaattatt ggtaatggga ggagaaaatt taaacagaac tgggatttgg gaccaccttc      120

tggaagatgt tagccaaaaa ccgaacagat cctaggcatc aaggggtgtg aatttcgagt      180

caccccgcca gaccccaggg cgctgcggct cactccacac tttcccggga accctacgcc      240

caggaggctc agcgaagctc caaaaccaat tttacggact gtactactga tccacctgtc      300

ggggagaaag actctacccg cagtttgacg aaaatggtcg tttccagatg cttgtaggat      360

ttcctcgcta agctccaccc tctgcggcgc cttcttctga ttggctctga gtaatcagag      420

ccaaagcgtt acttccggcg gaaaaggacg cgggagattc gattggaagg ctgccggcgt      480

gctactgagt tcggccggtc cgagtcactg tgcgtcgcct gggcccgttc ctggtcttct      540

cccccagggt cttgctctgt cacccaggct ggagtgccat ggcatcatca tagctcacta      600

tggccttgat cctcctgcct tagcctccca agcagctggt attacagacc acggtgtgaa      660

cacatgaaca gaagacgaaa atttcttcta gcctcagtac ttgctctcca gaattcaagt      720

tttatatatc catcatgtca gaagtgcttc tctaggataa tcctggtctc caaaaggtct      780

aattgtccaa aatgtggctc tactggtgaa tctggaaatg ccaattacag atacaaactt      840

tccttaaaag ttgcagaatc aaacaaattg tttgttatta ctgtatttg                  889


<210> 4122
<211> 481
<212> DNA
<213> Homo sapiens

<400> 4122
agacaaggaa cagtggaaca gttggcttga cgacagcgtc gggacccagc cctgcgcaac       60

tccacctgct tctgggaacc cagggggaag caagggaaga ccgtgacctt tgccccgggc      120

tgtggggagc cccggagcct gggcccggag aagcgcggtt aggcttgctg aggggcaggc      180

acaggagtcc tggctgagct catggcctga ggctgcctag cggccacggg gaatggttgc      240

aatggcggag gcagaggcag gggtggcagt ggaggtccgt ggactgcccc ctgccgtgcc      300

cgacgagctg ctcactctct actttgaaaa ccgccgacgc tctggagggg gacctgtgtt      360

gagctggcag agactgggct gtgggggcgt cctcaccttc agagagcctg cagacgccga      420

gagggtcttg gcccaggcag atcacgaact acatggtgcc cagctgagcc tgcggccagc      480

t                                                                      481


<210> 4123
<211> 1022
<212> DNA
<213> Homo sapiens

<400> 4123
ggagaggccc ctcctcagga aatgcgcccg tggaatgctc taccctcttc cgcagccagt       60

cgcccctggc cttcccaacc tcgcggctgc ccgaaggacc tgttgtgccg ggtccggaaa      120

gcgtgtttcg ctccctttcc cttgagggag tggggaggga atgtgactct tttcgcccag      180

cgccgtggac tcgcggcttg tggctcccaa gttagggagt gagaggatcg cccgccgagg      240

gggtggctcc gcagcccggc tgcgcgagac gcttcccgct cggggacccg ccttccgagg      300

ccaggtgaac gttaccggcc ccctgacctc cagcagatcc acacgtttgt tggagactga      360

accgttgcaa ggaacagacg aagatgcagt agccagtgct gacttctcta gcatgctctc      420

tgaggaggaa aaggaagagt taaaagcaga gttagttcag ctagaagacg aaattacaac      480

actacgacaa gttttgtcag cgaaagaaag gcatctagtt gagataaaac aaaaactcgg      540

catgaacctg atgaatgaat taaaacagaa cttcagcaaa agctggcatg acatgcagac      600

taccactgcc tacaagaaaa cacatgaaac cctgagtcac gcagggcaaa aggcaactgc      660

agctttcagc aacgttggaa cggccatcag caagaagttc ggagacatga gttactccat      720

tcgccattcc ataagtatgc ctgctatgag gaattctcct actttcaaat catttgagga      780

gagggttgag acaactgtca caagcctcaa gacgaaagta ggcggtacga accctaatgg      840

aggcagtttt gaggaggtcc tcagctccac ggcccatgcc agtgcccaga gcttggcagg      900

aggctcccgg cggaccaagg aggaggagct gcagtgctaa gtccagccag cgtgcagctg      960

catccagaaa ccggccacta cccagcccat ctctgcctgt gcttatccag ataagaagac     1020

ca                                                                    1022


<210> 4124
<211> 331
<212> DNA
<213> Homo sapiens

<400> 4124
gattggaagg ctgccggcgt gctactgagt tcggccggtc cgagtcactg tgcgtcgcct       60

gggcccgttc ctggtcttct cccccagacc acggtgtgaa cacatgaaca gaagacgaaa      120

atttcttcta gcctcagtac ttgctctcca gaattcaagt tttatatatc catcatgtca      180

gaagtgcttc tctaggataa tcctggtctc caaaaggtct aattgtccaa aatgtggctc      240

tactggtgaa tctggaaatg ccaattacag atacaaactt tccttaaaag ttgcagaatc      300

aaacaaattg tttgttatta ctgtatttgg a                                     331


<210> 4125
<211> 4949
<212> DNA
<213> Homo sapiens

<400> 4125
tcgccccttc tcggccgccg tagttttttt ttttttttaa agaaaaaacg gttacccagc       60

aactagaaaa acaaccggaa ccggcggcac cagctcggag agaaaggagg tgaggccgct      120

tccccacttc ctctccgata ccaagaccta gccttttccc ttcgtctctc ttattctctc      180

agcatcccag acacagcctc ggagccctgg gccgtttggg agccgaggca gcccattctg      240

cgcgagtctg aaatcccagg tcctcaacat cccgcccccg actagacccg tctgccccct      300

ccgcccgccc tcctctgccc acattggttc agaatctcgc cagctctttt caccactcta      360

gaatggttcg atacccccat ctactgctcc ctcagaaaaa gcaaaagaga ggagtcaggc      420

gtggtggcgc gcgcctgtaa tcccaattgc tcgggaggct gaggcgggat catcgctgga      480

gcccaggagt tcgaggccag agaccccctc tcaaagaaaa aaaaagcgat gaaacgagaa      540

ccctccatag tctgagcctc attaaaccgt ccagttctcc caacctggac ccctaccacg      600

gcctccgcct ctattccgca ttgacgcaca ctctcacatt aacaggccag gtcccggagg      660

attcttttca tactcagtag tagctcagcc cgctgcttag cagctaccct taatctagcc      720

cttgtatttc aagacagaaa gagacaacct gatcaagaag aaaccgaaaa atataagaat      780

tctaaaactt tagaggctgg gatttcaaaa tcatgacaca cagccccatc ccatcccatc      840

cctccctcac acacacgcac gcacaacccc attccacagt acgaaggtgt tcgaagcatt      900

gtgggtcatg cttcagaagt ggcagcaagg ggaaagattg tgcaacttct tcattcaaca      960

aattaatttc tagaaccagg actaatttct actctttaaa aaaaaataga cctcaaagaa     1020

ggtcttctca gcaattgaca atgaatttaa ctttttagca atcattctct ctaaattcct     1080

gtgtgatagc aaaaattacc cttacctttt gagcatataa agggtaaaga gagaaaaagt     1140

catattgaaa attatgggtt ttttgcagga ttttaaatga tttggcctag tgaatgggtc     1200

tgtgtttgta ttatactaat tcacaatgga gatttcaaaa ctctttggaa gaaatggatg     1260

ggcttgggtt gtgttaggga aaaaagaatt caagtccaga tgtatgagtc tcagaaataa     1320

tttgttggca tagttgtgat tatataagta aaatcagaca aatttaaaga cagtactctt     1380

taatgaatct ttaggttcca taggcagttc ttaccaagaa gatgtcgatt ccattctcca     1440

acacccacta ccgaattcca caaggatttg ggaatcttct tgaagggctg acacgcgaga     1500

ttctgagaga gcaaccggac aatataccag cttttgcagc agcctatttt gagagccttc     1560

tagagaaaag agagaaaacc aactttgatc cagcagaatg ggggagtaag gtagaagacc     1620

gcttctataa caatcatgca ttcgaggagc aagaaccacc tgagaaaagt gatcctaaac     1680

aagaagagtc tcagatatct gggaaggagg aagagacatc agtcaccatc ttagactctt     1740

ctgaggaaga taaggaaaaa gaagaggttg ctgctgtcaa aatccaagct gccttccggg     1800

gacacatagc cagagaggag gcaaagaaaa tgaaaacaaa tagtcttcaa aatgaggaaa     1860

aagaggaaaa caagtgagga cactggtttt acctccagga aacatgaaaa ataatccaaa     1920

tccatcaacc ttcttattaa tgtcatttct tcctgaggaa ggaagatttg atgttgtgaa     1980

ataacattcg ttactgttgt gaaaatctgt catgagcatt tgtttaataa gcataccatt     2040

gaaacatgcc acttgaagat ttctctgaga tcatgagttt gtttacactt gtctcaagcc     2100

tatctataga gacccttgga tttagaatta tagaactaaa gtatctgaga ttacagagat     2160

ctcagaggtt atgtgttcta actattatca aatgaataaa tcctctctat cacatccccc     2220

aaaaatgttc tttagctcct gtttcactcc tagtggtaaa gaatttcact gctttttaag     2280

gatagtctat ttaattttgg aatttttaga aagataagct gggacaaaaa tctgcctcct     2340

tcagcctggc caacatggtg aaaccccatg tctactaaaa gtacaaaaat tggccaggcg     2400

tggtgcgcac acctgtaatc ccagctactc gggaggctga ggcaggagaa tcgcttgaac     2460

ctgggaagtg gaggctgcag taagccgaga tcgcaccact gcactccagc ctgggcgaca     2520

gagcaagact ctgtctcaaa aacaaaacaa aacaaaaaaa agcctctgcc tccttgtaag     2580

tttaacccac tggttttcat ttatcataca tgtattcaat catttattga aaatgtattg     2640

agtactattc atgtgctggg aattagtagt gaatacttgt tcttacactc atacaactta     2700

caatgcttta ttgttttgct ctccagaacc acacagaaca agactaataa catcatattg     2760

taaaaagcaa aagctatcat atcatgctgc cttcttcagt taaaacttcc caagttttta     2820

aatatacaat ggtaatgcct gtttaacaaa ctcagaggct ttatctcttt tatgttttca     2880

atgattcatt caaatcccta gtgccttagt tttagaaagt tccgtctctc ctttttgagg     2940

cctctccacc cttgattgtc caagaaactg agggttcatg tcttagacca aagggtgcag     3000

ttctcttccc aatacaaaag gtagaaagtg gagtcttacc atttagttaa tgctgttgcc     3060

ttctaccata atgttgtagc atagtccagc agactgaggt gattctctgg ctggttccaa     3120

ttcctgcctg caccatagtg gatggcccat gatttagttc caggattaca tctctcttgg     3180

tttatagtca caaagccagt gttcccccaa agcttaaaaa caagccagga tggctcagtc     3240

ctgaggagat tctaaaacca ggtctatgtt gtcacaacaa atactctcct acaaacactt     3300

tgatccttgt cctaggctta gacatgctct ttctgcaaag cagttttatt tcaggtgcct     3360

cactgccctt ccctggcact gagcctttat caggctctgc aacagaggtt cccccaagtg     3420

atcgccactc aaacacagtt gattcacacc aaccctttca aggttgtggc tttcattctc     3480

taatgtccac tcatacaggc agcctttctc cttccaaaat cttgctgcca ctgtagagag     3540

tttcatgcta gctaaacaca agtctctaat atcccccttc ctctcctcct taacccctct     3600

cctccaggct tacagaggaa aagaaatcag ttctcctcca ggattccagc tgttcgtccc     3660

tcccattcca ctgaaagcac cagcttctaa caccttcccc tctcagacag agccatcctg     3720

cttagcggat tgtcaagggg ggacccagaa tttatgcaaa gacttagatt ccctgacctg     3780

gagagatcag aagaggaaaa aagggatttt ttccctagtg agtatatagc aggaaaaaaa     3840

aaaaagatga gttagctttt tcagtaattc tcctgttata cacataaagt gactagcact     3900

atgcattcca tacacacaca cacacacaca cagatctcat ggtagtgata ttggtagtga     3960

aggaggaaaa ggaaaaggtg agcaatggat gtgatattat gagaacaaca catatgaatg     4020

acactttatt agaacttatc tggttttcct cttatctctc tggctgttcc ttctcaattc     4080

ccttcactgg taactcttca actccccaac cactaaatgc taagtgccct taggctcagt     4140

ctttcgaccc catttctaca ctcacttgat ttcctgcagt ttcatagctt taaaatccaa     4200

tcttcttaat gatcactccc agacctttct ctcctctgcc tgcgaacttc tatattcaac     4260

tgcctacata acatccccat ttggatgtct ataggcatct caaaagtaac atataaaaaa     4320

tgaatcctga tattgccccc aaatctgaaa cttcccccac acccaagttt ttccattcaa     4380

aaatggctgc tccattcttc catttgctca ggccaaaaac cttggattca tctttaatgc     4440

gtcactttct ttcacacccc atatacaatc tatcagcaaa acctgtgggc tgtacctata     4500

aaataatact cagaatctgc ctacttctaa ccacttccat tgttaccgcc ttggtcctag     4560

ttcccatgat agccttgtga attattgcaa taacctatat tggccagtga ttatctcact     4620

actactgcac aacccattcc aaagttagtg gtttaagaca attatatttt ctcctgggtc     4680

tgtaggtcag tggtaatgta gctaagctag gctggactac aatctcaagg ttaggttcag     4740

gtcagctcta agctgtgggt ttgtgggctg acaggaaggt ctgcttcagg ctgtgggccc     4800

aagggtcagc tgcagcacag tgcctctgct tcacgtgtcc ttttctgagc ccctgctgaa     4860

agacgttatc caggacaagc tcttctcatg ctggtcacag aagacaagca ggaaaaccca     4920

gcatgcaaga atatttcaag cttttgctc                                       4949


<210> 4126
<211> 555
<212> DNA
<213> Homo sapiens

<400> 4126
tttggaggtc cggcacccgc tctgcccatg cctatgcttc aggctctgtg agaaggctgg       60

actccttctg gaacttcagg accttggatg ctcccctcct ctgctcctgc ctcccttccc      120

ccagccctgg ggtgtgtcag atgtgtgttt tctcctggac tcagctgaag caaggtgtgt      180

ctctagtcct cgtggttgcc tgccccactc cctgccgaga cgcctgccag aaaggtcacc      240

tatcctgaac cccagcaagc ctgaaacagc tcagccaagc accctgcgat ggaagctgca      300

gatgcctcca ggagcaacgg gtcgagccca gaagccaggg atgcccggag cccgtcgggc      360

cccagtggca gcctggagaa tggcaccaag gctgacggca aggatgccaa gaccaccaac      420

gggcacggcg gggaggcagc tgagggcaag agcctgggca gcgccctgaa gccaggggaa      480

ggtaggagcg ccctgttcgc gggcaatgag tggcggcgac ccatcatcca gtttgtcgag      540

tccggggacg acaag                                                       555


<210> 4127
<211> 1708
<212> DNA
<213> Homo sapiens

<400> 4127
tgcgtcttcc tgactctagt acgttgaatc tggccagaaa aaccacattt gctctctacg       60

aactctccgc ccagttcgcc gcaactacta cgacccctcc tcggcccctg ggaagggcgt      120

ggtgtgggag tgggagaacg acaatggctc ctggacgccc tacgacatgg aagtgggcat      180

caccatccag catgcctatg agaagcagca cccctggatc gacctcactt ccattggctt      240

tagctacgta attgacttca acaccatggg ccagatcaac cgtcagaccc agcgccaacg      300

ccgcgtccgc cggcgcctcg acctcatcta ccccatggtc acagggacct tgcctaaggc      360

tcagtcctgg ccagtcagcc ctgggccagc cacctcgccc cccatgtccc cctgctcctg      420

tccccagtgt gtcttggtga tgagtgttaa ggcagccgtg gtcaatggca gcactgggcc      480

cctacagctg ccagtgaccc gcaagaacat gccgcctcct ggagtggtca agctaccccc      540

actgccaggc tctggggcca agccactgga cagcacaggc accattcgag gcccactgaa      600

gaccgcccca tcgcaggtga tccggagaca agcctccagc atgcccactg ggacaaccat      660

gggctctcct gccagtcccc caggacccaa cagcaagacc ggaagggtgg ccctggccac      720

cttgaatcgt accaacctgc agcgactggc cattgcccag tcccgggtgc tgatcgcctc      780

tggggtcccc acagtcccag tgaagaacct aaatgggtcc agtcctgtca accctgcctt      840

ggcaggaatc actgggatcc tcatgagtgc agcggggctg cctgtgtgtc tcaccaggcc      900

accaaagctg gtcctacacc caccccccgt cagcaagagt gaaataaaat ccatcccagg      960

ggtttccaac acaagccgca agaccaccaa aaaacaagcc aagaaaggta aaaccccaga     1020

ggaagtgcta aaaaaatatc tacagaaagt ccggcaccca ccagatgagg actgcaccat     1080

ctgtatggaa cgcctcacgg ccccctcagg ctacaagggc ccgcagccta cggtaaaacc     1140

tgacctggta gggaagctgt ccagatgcgg ccacgtctac cacatctact gcttggttgc     1200

catgtacaac aatgggaaca aggatggaag tttgcagtgt ccaacctgca agaccattta     1260

tggggtgaag acaggcaccc aacctccagg gaagatggag taccacctca tcccccactc     1320

cttgcctggc cacccagact gcaaaaccat ccggatcatc tacagcatcc cccccggcat     1380

tcagggaccg gaacacccga atcctgggaa gagtttcagc gcccgaggct tcccacgaca     1440

ctgttacctt ccggacagcg agaaagggag aaaagttctg aagctgctgc tcgtggcctg     1500

ggatcgccgc ctcatttttg ccattggcac ctccagcacc acaggcgagt cagacaccgt     1560

catctggaat gaggtccacc acaagacaga gtttggctct aatctcactg gccatggcta     1620

cccagatgcc aattacctgg ataatgtgct ggctgaactg gctgcccagg gcatctctga     1680

ggacagcact gcccaggaga aggactga                                        1708


<210> 4128
<211> 683
<212> DNA
<213> Homo sapiens

<400> 4128
ctctccccca ctgttagacc tcagcagcca gcagcccgcc gcccggcgct gcagctccct       60

gcccgcagga gccacgtctc gcgcgactcc ccccacctct cgcgacactt gccgcccgtg      120

ccctgcggcc ctgcacgccc cacccgcggt cgcgcgccgc gctccccgcc gcctcacctt      180

ttcgcctggc atccgggccc gctactcgcc cactgggagc gccgtggcgc ctggtgttcg      240

gcgcgagccc ggcggggctg cagagagcga aatgtcatca gtgcagtcac aacaggagca      300

gttgtcccag tcagatccat ctccgtcacc aaactcatgt agttcctttg agctaataga      360

catggatgct ggcagcttgt atgaaccagt ttctccccat tggttttatt gtaagataat      420

agattctaag gagacatgga ttcctttcaa ctctgaggat tcacagcagc tggaagaggc      480

atatagctct ggaaaaggtt gtaatgggag agttgttcct actgatgggg gcagatatga      540

tgttcatttg ggggagagga tgcggtatgc tgtatactgg gatgaactgg catcggaagt      600

gagacgatgt acgtggtttt acaaggggga caaagacaat aagtatgttc cctactcgga      660

gagcttcagc caagttttag agg                                              683


<210> 4129
<211> 551
<212> DNA
<213> Homo sapiens

<400> 4129
attttgggcg cttcgctgat ggtgtcggtg agcgcgtttc ccgcctgagc gcaactagcg       60

gcgggtcgtg ggcacctcca ggagagcttg tttcatatcc atatcccact gtattcctgc      120

taatctgcta atgcagtaaa ttggaggaaa actgttacca ggataacctg taatgggcaa      180

ggagccacaa agaagaaaac atttctttta atttttaaac ttggtttgaa agaaaaattt      240

cgttctttgc cctgtgctca gaagatcaca ataaaacttc accacatcaa gctgctgtgg      300

gatagggcaa accgggatgg ttaagtccat gagtgcatga agtttactgt tggtgctact      360

ggttcagtaa caggtgatgg atttcaaaag tctccagatg cctgctggcg aataatcaaa      420

gaataactac cagcatgttt tggaaatttg atcttcactc atcatcccac atagacacac      480

ttctagaaag agaagatgta acactgaagg agttaatgga tgaggaagat gttttacagg      540

aatgtaaagc t                                                           551


<210> 4130
<211> 7606
<212> DNA
<213> Homo sapiens

<400> 4130
gtcattgagc tgatgtgctt ttgcaagggg tctctttaga agtggtaggg gcagggtcga       60

gagaagaagg ggatgcagaa tctgtacatg aggaaggagc cagagtcact caggaaactc      120

ctcattcttc ctgcgctggc tgtggcacac ccaccggtgg cacacccctc cctcgggtcc      180

agttcagccc acagactcct gggaggagag ccagggcccc agcctctcct ttgaggagtg      240

ttgcagcctt tctgtgtgcc agatgcctag tgaagaaaag ctgaaaccct ggagctttgt      300

gcatgttaat gaccttggaa atgactgagc tcacggaccc tcatcacacc atgggagact      360

acaaagtggc ccaccctcag gaccctcacc acccatcaga gaagcctgtc attcactgcc      420

ataaatgtgg ggagccttgc aagggtgaag tgcttcgggt ccagaccaaa catttccaca      480

tcaagtgttt cacctgcaaa gtgtgtggct gtgacctggc acaagggggc ttcttcataa      540

agaacggaga gtatctctgc accctggact accagcggat gtacgggaca cgctgccatg      600

gctgtgggga gttcgtggag ggcgaagtgg tgactgctct gggcaagacc taccatccca      660

attgctttgc ttgtactatc tgcaagcgcc cgtttccacc cggagaccga gtcacattca      720

atgggagaga ctgcctttgt caactctgtg cacagccgat gtcgtccagt ccgaaagaaa      780

ccaccttctc cagcaattgt gccggctgcg gaagagatat caagaatggg caggcgctgc      840

tggcgctgga taagcagtgg cacttggggt gctttaaatg caagtcctgc gggaaggtcc      900

tcaccgggga gtacatcagc aaggatggtg ctccgtactg tgaaaaggac taccagggac      960

tctttggggt gaaatgtgag gcgtgtcacc agtttatcac agggaaagtc ctggaggcag     1020

gtgacaaaca ttaccacccc agctgtgcac gatgcagcag atgcaaccag atgttcacag     1080

aaggagagga aatgtatctt caaggctcca ccgtttggca tcccgactgt aagcaatcta     1140

cgaagaccga ggaaaagctg cggcctacca ggacatcctc ggaaagtatt tattctaggc     1200

caggctccag tattcctggc tcaccaggtc atactatcta tgcaaaagta gacaatgaga     1260

tcctggatta caaggattta gcagccattc cgaaggtcaa ggcaatttat gacattgaac     1320

gtccagatct tattacctat gagcctttct acacttcggg ctatgatgac aaacaggaga     1380

gacagagcct tggagagtct ccgaggactt tgtctcctac tccatcagca gaagggtacc     1440

aggatgttcg ggatcggatg atccatcggt ccacgagcca gggctccatc aactcccctg     1500

tgtacagccg ccacagctac actccaacca cgtcccgctc tccccagcat ttccacagac     1560

ctggcaatga gccgtccagc ggccggaact cccctctccc ttaccggcca gacagccgcc     1620

ctctaactcc aacttacgct caggccccta aacatttcca tgttccagat caaggaatca     1680

acatttaccg aaagccaccc atctacaaac agcatgctgc cttggcagcc cagagcaagt     1740

cctcagaaga tatcatcaag ttttccaagt tcccagcagc ccaggcacca gaccccagcg     1800

agacaccaaa gattgagacg gaccactggc ctggtccccc ctcatttgct gtcgtaggac     1860

ctgacatgaa acgcagatct agtggcagag aggaagatga tgaggaactt ctgagacgtc     1920

ggcagcttca agaagagcaa ttaatgaagc ttaactcagg cctgggacag ttgatcttga     1980

aagaagagat ggagaaagag agccgggaaa ggtcatctct gttagccagt cgctacgatt     2040

ctcccatcaa ctcagcttca catattccat catctaaaac tgcatctctc cctggctatg     2100

gaagaaatgg gcttcaccgg cctgtttcta ccgacttcgc tcagtataac agctatgggg     2160

atgtcagcgg gggagtgcga gatttccaga cactcccaga tggccacatg cctgcaatga     2220

gaatggaccg aggagtgtct atgcccaaca tgttggaacc aaagatattt ccatatgaaa     2280

tgctcatggt gaccaacaga gggcgaaaca aaatcctcag agaggtggac agaaccaggc     2340

tggagcgcca cttagcccct gaagtgtttc gggaaatctt tggaatgtcc atacaggagt     2400

ttgacaggtt acctctttgg agacgcaacg acatgaagaa aaaagcaaaa ctcttctaag     2460

tcccactcgt gaatggcaat tagagaaagg actgacagtg gcggtgcccc ataggatgtc     2520

atattgaggc ccaaacttga ttggagaatt tgcaaactac cgtcgctcag caacaccaaa     2580

aagagaaagt ctggttaaaa caccatgagt caaatgtcgg gccagccaac agtaacactt     2640

gccaagaagc atggcgtaga aatttctatg ttccgaaaca cagagtagtg tccacatgtg     2700

agcttttcac attaccttat gtatacaaca ggagctgcgt tgttttcttc tttttctttt     2760

cctttatctg ttgtccaaca acagtgctga ctgtccggat aagagctggc aagtgccctt     2820

aggatgccgc atgggaaaaa tcggttatca taatttcaaa gtataaatat atttattaag     2880

tagcgctgcg gctaagaagg aagagtgagg ggtctgtcca tggggtggca gtgatttcac     2940

acccgccttt cttgaatggc ttcgtgttac tcagccgtgc cctggcagga atggaactcc     3000

atcagggaac agggcagctc tgtttgaatg gggtgaaaaa cagcaaaatt aattcttagc     3060

aagctccttg ttctctactg ttcaccggga cctggctggc aaatgactta gctattagta     3120

tatttaaaaa ctgttcaaaa gcaaaagaga aggaacagga atgaaaggaa accttccctt     3180

aactctttct gcttcccata gcaggtctgg ttcctgctcc ccgcctagga caggagctgt     3240

ctggagctcc acctttgcaa agaaaggaaa aacacaaatt gcccccagat tggcccagtg     3300

gcatgccatt aggtgatttt gcataggggc catatcattc atggccaaaa aaaaccaaaa     3360

agcaaaaaac aaaaacaagt cccatgtcct actgactcta gttcttccag tcgttatcct     3420

ctgctgtctc tctggcatcc tatgaatcag atcaagccca tgctgttgtt ggtttttaag     3480

gtttctttca ataataggct aaggaaagac atgtttttct cttttaaatc tctgcaactc     3540

caaagtagac tccttcgaac gtatttaatt tggccttttc agctttcttc ttgcccagct     3600

ctgtcgaatt catgggtgtg tgtgcacatg ttggtttcac tcacccagag taattttgtg     3660

agcatgcatg tgctttttaa tttctgcttg aatgtttgtc ctgctgtgtt gcagcttcta     3720

aagacattgt caccgagtgt gtgtgactca aagatcaaga gtgaggctaa actgcgaccc     3780

caacatcact tccttcatgg aaaggtgttg gcgctgatgt agctcatgga aggatcagac     3840

tgggaaccac agaggaagga tgaggtggga tgtggaggtc agagcatctc acgagagtcc     3900

ctcaggctct gcaacactag attcgaatat gagcctaggg tttccccaac acgtgcgtgc     3960

atatgaaacc acatcatgat tcccgacgtg agttagatga gggagagttt gtgtaactcc     4020

acacccagga gggtaagcca ctttattatc atgctttggg gctgtgctta agaatttaag     4080

ctctgtttta aagccgaaga agaaaacatt tgaatttacc ttcatatgcc actaagaaca     4140

aaagctctga agttcttcct gctggcacca aatattagga ttacaagctg tctctctgac     4200

accagtggta aaaaagcaag tagaatagtt tctgagtctg tgttgcagcc tctgacacgt     4260

ggctcaccgc tgtcatttgg gggatggaat gaacagtcac tgttctatag catcctcctg     4320

tgctcttacc taaggaatct aaattgtcct agccttccat tgctatgcac tgaatgagga     4380

ctactctcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg     4440

gatctactaa catgtttagc aaatggctct gacagggtgg ccatgagcag atgagaccag     4500

ctcttgcttg gttggaagcc acactgcagt ttgcagttta gcctttggtg tctcagtggc     4560

ttcttgctta ttccatgctt tttctatccc atcctctctc tgtgccctcc tgcaatggca     4620

gccttggcac aatgcctggg tgtcctcatc cttgctttac tctggaaagt gtggggatgg     4680

agaggatggt gcatttccag tgcttcctta cctgtcaata acaatggtgg ccacctgggt     4740

cccagcactt ggctggtgga gagatttttt tcattatgga gctaataaag ggtccctacg     4800

ttttacattg attaatgaat tatcacccag acatgtgcag atgaaatgtc aatataagaa     4860

aaatcaaggt atttgggaaa catgggcata atcaggtagt tttgctaaaa ttcctcttcc     4920

ttggtctaca taaagaagac atgggtctgt catagaatgg ggacattaga ctgaaaactg     4980

ggacaacccc cttccttatt ttatagagac taggagttaa ggggcctgcc taagattgca     5040

gtgataaaga actgaaccct aaatcagctc ccactaatga aaccctgctt tccttgtatc     5100

ttttaaactc agttctgcat ccaacttgag aagaaaaaaa gcttctttcc atatcaagta     5160

ccatatgagt tcatttaaac tgcaccttgc agaaatgcat tgccagaaag caccagtagc     5220

ctcctatctg caagcagagt agtgctctgc tctggggagg ggtcattgga aaccataatg     5280

cagagtgggc cccctactcc atttcccagc aaaaggctcc agctggaggg atgggttgtg     5340

gggcaacctg gttcctgcta actgccagat tgaatgtgtg ggctagaatg cctgcacatt     5400

tagttaaact gggctcagca tgcttgtcct caaaatgtcc atcctggtca cagcacacaa     5460

gatggctatt ggtctgcttt taccctaccc tgtactatac atgaaaattc cagttattaa     5520

cacactcaaa ctggtggagc ttgttcaccc taggaagggg attgtatata tggcaggctt     5580

ccctggtgcc gatgtaaagg gctacatttg ggaacatttg acttccttgg gactcttaag     5640

tgcataatga tggcatgaag taaaaggggc ctcaatgatg ataggaaaat cagttctttt     5700

aaaatttctt caagaaaatc caggctatca catagtcttt ctgtgtgact tattaggaga     5760

taggaagagc attgggaaac ttgcacagct agctatgcat ctacattttg gtttggggtt     5820

agttatgaaa tgttcttaat atgacgtgtt caataacttc acataaactt cctgttctcc     5880

aaaacctcaa agagatagag ttaatgagtt gttgtttttt tttaaatggg ggtagttttc     5940

tatctgtcat gggctctagc atctactccg ctacccaatt ctgtcatctc caagctgagt     6000

ttcctcttct gaggcagagg ctggagcagt tctttttcag ttctcatcct ctccatccca     6060

atccagtata tcaatcaact ctaactcgga gacgtctagc tggcaatgtt tctaaaactt     6120

tcactggatt tctttagaca ttgaagcaaa catttttttc taagaattgc ttctcagatg     6180

atgatatcaa atgtatatgc ttttgcaagt ttgaaaagtt caaattaacc acttttgact     6240

aggtaagtct ttctaaaaac catttaaagc taactgggtc ttagcatcct cctgtgtatg     6300

gaagagacag gtgaccgctc caggttgggt gctcacagaa cccttttcct gactctcatg     6360

gaagatggtg gaaggaaaat agactgtctc atcaaccctc ctgtgtcctc tgaagcaatc     6420

tcagttttta ttaaccacct cttctgtgtt tctggtagct atttaacctg tatttaatct     6480

gtacttccta tgccagcctc aattttattt gatttttaca attattctct tctaaccaat     6540

gaagtgtttg tcagtatgcc ccaaagcttg ctcttttgtg ctcccttttg aataactttc     6600

tatccagaaa aagagattat ttgggacttg agatttgcag tgataccaac ttatagcaat     6660

gatgtacttt aagggaacta cccaactatg ttgtgataga agaaagagaa accttcactt     6720

tggcattttt ttttaatcac tgtttatttt tctgtttgcg gcccaggaag cagtgggagg     6780

tggtggcaga tatgctttgc atatggattg ttatgttttt atttgggcaa gtttaatcat     6840

ggaaaactca aaaagaaggg gggaaatggt cagtttaagc caaaagaaac tttctaaaca     6900

atgtataggt acacagcaaa attaaacaaa tccaacaatt tctgaagctt agtgtaattg     6960

agtggtggtt gttattcaat aaaattattc ccaaaagtgt ttctcctaag agtgcagttc     7020

ccatgagtca cttcctgaac ccattgacca aaggtggaca gagacaatcc tgtagacctt     7080

gacattcaga aagatgtgag ctgcttactg atcatatatg catacgtttc tttacagcag     7140

aggaaaccat tgtccacaaa actgatgttc ttttggggtt ttatgtacag acttgtccaa     7200

tcatgtgtgt ggttcctgcg agttgctgat gactccgcat tgaagctctc tgagttcttt     7260

gattttaagt tgggtttatg gaattttttc aaatgttgga aggtgtgtgg ttcttcctgc     7320

cctccctccc cttttggaaa tatgaaagca aatgtttaga agaattcctt ttgaaaagct     7380

gtgtcgtgtt ccctgtgaaa ctgagcaggt gtgtgttggc gcgctaagtg ccacatgctt     7440

gtgtgtagag gaggaggtgg ccctgccggc tccgcgctgc tgtgcctgtg atccctacct     7500

gctccccgct cctgttgcca gcagcactca ctgcactcct ttgtcatata ctctgcatca     7560

ctgtcatact cacaacttcg tgaataaagt tgtgtgcttt attcgt                    7606


<210> 4131
<211> 3266
<212> DNA
<213> Homo sapiens

<400> 4131
gtgactccgc aacctgtcgc tcaggttcct cctctcccgg ccccgccccg gcccggcccc       60

gccgagcgtc ccacccgccc gcgggagacc tggcgccccg gccgaggcgc gaacagacgg      120

acgcaccggc gagcgccgag gggacaggcc gagcgcgggg cgccggaggc aggaccctcc      180

cgagggcctg accgtggagg tagcactgca cacccactcc ctgtgggccg gagccaggag      240

gcacttcctg ggtgtcggag cccagaagga aaccagtggc cgggaagcac cagctgggtg      300

tgggacaggc actggcctca gaccggggcc acactgaggt ctgcccttct cccgctggcc      360

gccacccaag acaccatgag ccagtccggg gccgtgagct gctgcccggg tgccaccaat      420

ggcagcctgg gccggtccga cggtgtggcc aagatgagcc ccaaggacct gtttgagcag      480

aggaagaagt attccaactc caacgtcatc atgcacgaga cctcgcagta ccacgtccag      540

cacctggcca cattcatcat ggacaagagc gaagccatca cgtctgtgga cgacgccatc      600

cggaagctgg tgcagctgag ctccaaggag aagatctgga cccaggagat gctgctgcag      660

gtgaacgacc agtcgctgcg gctgctggac atcgagtcac aggaggagct ggaagacttc      720

ccgctgccca cggtgcagcg cagccagacg gtcctcaacc agctgcgcta cccgtctgtg      780

ctgctgctcg tgtgccagga ctcggagcag agcaagccgg atgtccactt cttccactgc      840

gatgaggtgg aggcagagct ggtgcacgag gacatcgaga gcgcgttggc cgactgccgg      900

ctgggcaaga agatgcggcc gcagaccctg aagggacacc aggagaagat tcggcagcgg      960

cagtccatcc tgcctcctcc ccagggcccg gcgcccatcc ccttccagca ccgcggcggg     1020

gattccccgg aggccaagaa tcgcgtgggc ccgcaggtgc cactcagcga gccaggtttc     1080

cgccgtcggg agtcgcagga ggagccgcgg gccgtgctgg ctcagaagat agagaaggag     1140

acgcaaatcc tcaactgcgc cctggacgac atcgagtggt ttgtggcccg gctgcagaag     1200

gcagccgagg ctttcaagca gctgaaccag cggaaaaagg ggaagaagaa gggcaagaag     1260

gcgccagcag agggcgtcct cacactgcgg gcacggcccc cctctgaggg cgagttcatc     1320

gactgcttcc agaaaatcaa gctggcgatt aacttgctgg caaagctgca gaagcacatc     1380

cagaacccca gcgccgcgga gctcgtgcac ttcctcttcg ggcctctgga cctgatcgtc     1440

aacacctgca gtggcccaga catcgcacgc tccgtctcct gcccactgct ctcccgagat     1500

gccgtggact tcctgcgcgg ccacctggtc cctaaggaga tgtcgctgtg ggagtcactg     1560

ggagagagct ggatgcggcc ccgttccgag tggccgcggg agccacaggt gcccctctac     1620

gtgcccaagt tccacagcgg ctgggagcct cctgtggatg tgctgcagga ggccccctgg     1680

gaggtggagg ggctggcgtc tgcccccatc gaggaggtga gtccagtgag ccgacagtcc     1740

ataagaaact cccagaagca cagccccact tcagagccca cccccccggg ggatgcccta     1800

ccaccagtca gctccccaca tactcacagg ggctaccagc caacaccagc catggccaag     1860

tacgtcaaga tcctgtatga cttcacagcc cgaaatgcca acgagctatc ggtgctcaag     1920

gatgaggtcc tagaggtgct ggaggacggc cggcagtggt ggaagctgcg cagccgcagc     1980

ggccaggcgg ggtacgtgcc ctgcaacatc ctaggcgagg cgcgaccgga ggacgccggc     2040

gccccgttcg agcaggccgg tcagaagtac tggggccccg ccagcccgac ccacaagcta     2100

cccccaagct tcccggggaa caaagacgag ctcatgcagc acatggacga ggtcaacgac     2160

gagctcatcc ggaaaatcag caacatcagg gcgcagccac agaggcactt ccgcgtggag     2220

cgcagccagc ccgtgagcca gccgctcacc tacgagtcgg gtccggacga ggtccgcgcc     2280

tggctggaag ccaaggcctt cagcccgcgg atcgtggaga acctgggcat cctgaccggg     2340

ccgcagctct tctccctcaa caaggaggag ctgaagaaag tgtgcggcga ggagggcgtc     2400

cgcgtgtaca gccagctcac catgcagaag gccttcctgg agaagcagca aagtgggtcg     2460

gagctggaag aactcatgaa caagtttcat tccatgaatc agaggagggg ggaggacagc     2520

taggcccagc tgccttgggc tggggcctgc ggaggggaag cccacccaca atgcatggag     2580

tattattttt atatgtgtat gtattttgta tcaaggacac ggagggggtg tggtgctggc     2640

tagaggtccc tgcccctgtc tggaggcaca acgcccatcc ttaggccaaa cagtacccaa     2700

ggcctcagcc cacaccaaga ctaatctcag ccaaacctgc tgcttggtgg tgccagcccc     2760

ttgtccacct tctcttgagg ccacagaact ccctggggct ggggcctctt tctctggcct     2820

cccctgtgca cctggggggt cctggcccct gtgatgctcc cccatcccca cccacttcta     2880

catccatcca caccccaggg tgagctggag ctccaggctg gccaggctga acctcgcaca     2940

cacgcagagt tctgctccct gaggggggcc cgggaggggc tccagcagga ggccgtgggt     3000

gccattcggg ggaaagtggg ggaacgacac acacttcacc tgcaagggcc gacaacgcag     3060

gggacaccgt gccggcttca gacactccca gcgcccactc ttacaggccc aggactggag     3120

ctttctctgg ccaagtttca ggccaatgat ccccgcatgg tgttgggggt gctggtgtgt     3180

cttggtgcct ggacttgagt ctcaccctac agatgagagg tggctgaggc accagggcta     3240

agcaattaaa ccagttaagt ctccca                                          3266


<210> 4132
<211> 1021
<212> DNA
<213> Homo sapiens

<400> 4132
ccccggccat taccgaagcg gatgaaaaca aacactaacg atggcggcgc cgggaagcga       60

ccggctgctg ggcttaaggc gggagtgacc gcttaaccag tgagggaagc actgaagagc      120

gccagtcgac gtgggtgcga caactcgcgg agtcttagga gcaaaacgtc tggggcctgc      180

gagccaggac ccttctgaag ccttaggtgt ctatcggcga cgtgtacggt cactgcagct      240

ccggagcgcg gaaccctcag ccaggaggcg cggctggtcg gtcccaggtc ccggcctccg      300

taatgagagc ccggaaccac tctttgtgcc gcagcttcgc aggtgagggt gactgttgac      360

tagtgaaaaa agggacccat ggttcacgac tgtcttctta ctggcagtgg aacgacctgt      420

ggaaacctgt gatccattct cattaaataa atctctggca tcttggactc aagtgattct      480

cctgcctcag cctcctgagt agctgggact acaggacaga aaattttaat aacaagatag      540

taagcagctc acatgaactt acatattcag catattagca ggaaagaggc aagacatttg      600

aagaacttgc agaaaagttg caaagtaaat gagagactag aatgctcaaa gattcctata      660

ggcaatggaa actgatctca attcccagga cagaaaggac ctggacaagt ttattaaatt      720

ttttgccctc aagactgtcc aagtgattgt ccaggctcgg cttggtgaaa agatttgcac      780

tcgttcatca tcttctccaa cgggttcaga ttggttcaac ttagcaatca aagacatccc      840

agaggttaca catgaagcaa agaaggcact ggcaggacag ctgcctgcag tcgggaggtc      900

catgtgtgtg gagatttcac ttaagacttc tgagggagat tccatggagc tggaaatatg      960

gtgtcttgaa atgaatgaaa agtgtgataa agaaatcaaa gtttcctaca cggtgtacaa     1020

c                                                                     1021


<210> 4133
<211> 586
<212> DNA
<213> Homo sapiens

<400> 4133
agactaccgg cggcgacgac cacaggagag acggggtttc accacatctc tggtcatggt       60

catggccagg ctggttttga actcctgacc tcaagtgatc cacccacctc ggcctcccaa      120

agtgctggga ttacaggcgt gagccactgc accggtcctg gctaagcatg gcggacaccg      180

acctgttcat ggaatgtgag gaggaggagt tggagccatg gcagaaaatc agtgatgtca      240

ttgaggactc tgtagttgaa gattataatt cagtggataa aactaccaca gtttctgtga      300

gccagcagcc agtctcggct ccagtgccca tcgctgccca tgcttctgtt gctgggcacc      360

tctctacatc caccaccgtt agtagcagcg gggcacagaa cagcgacagt acaaagaaga      420

ctcttgtcac actaattgcc aacaacaatg ctggcaatcc tttggtccag caaggtggac      480

agccactcat cctgacccag aatccagccc caggtctggg cacaatggtt actcaaccag      540

tattgaggcc tgttcaggtc atgcagaatg ccaatcatgt gactag                     586


<210> 4134
<211> 819
<212> DNA
<213> Homo sapiens

<400> 4134
tgcctgacat tgtgtagctg tatcaggctg gctttctgga atagctcagt ggccaaagat       60

tgatcacgaa gggtttagag ctgtgaaaat gccccagacc ttagctggat ctccaaaata      120

caagtgaatc acccggcagt tctgaggcgt gcggaacaaa tccaggctcg cagaaccgtg      180

aaaaaggagt ggcaggctgc ttggctcctg aaagctgtta cctttataga tcttactaca      240

ctttcaggtg atgatacatc ttccaacatt caaaggctct gttataaagc caaataccca      300

atccgggaag atctcttaaa agctttaaat atgcatgata aaggcattac tacagccgcc      360

gtttgtgttt atcccgcccg ggtgtgtgat gctgtaaaag cactcaaggc tgcaggctgt      420

aatatccctg tggcatcagt ggccgctgga tttccagctg gacagactca tttgaagaca      480

cgattagaag agatcagatt ggctgtggaa gatggagcta cagaaatcga cgtggtaatt      540

aacagaagct tggtgctgac aggccagtgg gaagccctgt atgatgagat tcgtcagttt      600

cgcaaggcct gtggggaggc tcatcttaaa actatattag cgacaggaga acttggaact      660

cttactaatg tctataaagc cagtatgata gcaatgatgg caggatcaga ttttattaag      720

acctctactg gaaaagaaac agtaaatgcc accttcccgg tagctatagt aatgctgcgg      780

gccattagag atttcttctg gaaaactgga aacaaggta                             819


<210> 4135
<211> 550
<212> DNA
<213> Homo sapiens

<400> 4135
tcggctcact gcaccctccg cctcctgggt tcaagcgatt ctcctccttc agcttcctca       60

gtagctggga ttacaggcac gcgccaccac acctggcatg gcggacaccg acctgttcat      120

ggaatgtgag gaggaggagt tggagccatg gcagaaaatc agtgatgtca ttgaggactc      180

tgtagttgaa gattataatt cagtggataa aactaccaca gtttctgtga gccagcagcc      240

agtctcggct ccagtgccca tcgctgccca tgcttctgtt gctgggcacc tctctacatc      300

caccaccgtt agtagcagcg gggcacagaa cagcgacagt acaaagaaga ctcttgtcac      360

actaattgcc aacaacaatg ctggcaatcc tttggtccag caaggtggac agccactcat      420

cctgacccag aatccagccc caggtctggg cacaatggtt actcaaccag tattgaggcc      480

tgttcaggtc atgcagaatg ccaatcatgt gactagttcc cctgtggcct cacaaccaat      540

atttatcact                                                             550


<210> 4136
<211> 587
<212> DNA
<213> Homo sapiens

<400> 4136
acgcaccggc gagcgccgag gggacaggcc gagcgcgggg cgccggaggc agctctgggg       60

cttggtgggg gcaatccctg cgtccggaga gcgctggtgg tagggaggct tctcccggtt      120

ctgtgagcag caggaccctc ccgagggcct gaccgtggag gtagcactgc acacccactc      180

cctgtgggcc ggagccagga ggcacttcct gggtgtcgga gcccagaagg aaaccagtgg      240

ccgggaagca ccagctgggt gtgggacagg cactggcctc agaccggggc cacactgagg      300

tctgcccttc tcccgctggc cgccacccaa gacaccatga gccagtccgg ggccgtgagc      360

tgctgcccgg gtgccaccaa tggcagcctg ggccggtccg acggtgtggc caagatgagc      420

cccaaggacc tgtttgagca gaggaagaag tattccaact ccaacgtcat catgcacgag      480

acctcgcagt accacgtcca gcacctggcc acattcatca tggacaagag cgaagccatc      540

acgtctgtgg acgacgccat ccggaagctg gtgcagctga gctccaa                    587


<210> 4137
<211> 492
<212> DNA
<213> Homo sapiens

<400> 4137
ggactgaggg aagaagtgaa aatcggactg ccaggcgaca gttcctccgt ttgaaatctc       60

gccggctcct gagcgggcca ccgggcccgg gctgggggtc tggcgggtgt ttgagcccag      120

atgagtcatg gctggacgac ccctccgcat aggagatcag ctggttctgg aagaagatta      180

tgatgagacc tacattccta gtgagcaaga aattcttgaa tttgcccggg agattggtat      240

tgatcccatc aaggaaccag aactgatgtg gctggcgcga gagggcatcg tggccccact      300

gcctggagag tggaaaccat gccaggacat cacaggtgac atttactatt tcaacttcgc      360

caacgggcag tctatgtggg accatccatg tgacgaacac tatcggagct tggtgatcca      420

agagcgggca aagctgtcaa cttctggggc cattaagaag aagaaaaaaa aaaaggaaaa      480

gaaagacaag aa                                                          492


<210> 4138
<211> 3533
<212> DNA
<213> Homo sapiens

<400> 4138
gggagattcg attggaaggc tgccggcgtg ctactgagtt cggccggtcc gagtcactgt       60

gcgtcgcctg ggcccgttcc tggtcttctc ccccagggtc ttgctctgtc acccaggctg      120

gagtgccatg gcatcatcat agctcactat ggccttgatc ctcctgcctt agcctcccaa      180

gcagctggta ttacagacca cggtgtgaac acatgaacag aagacgaaaa tttcttctag      240

cctcagtact tgctctccag aattcaagtt ttatatatcc atcatgtcag aagtgcttct      300

ctaggataat cctggtctcc aaaaggtcta attgtccaaa atgtggctct actggtgaat      360

ctggaaatgc caattacaga tacaaacttt ccttaaaagt tgcagaatca aacaaattgt      420

ttgttattac tgtatttgga agttgcttag atacattttt tggtcttact gccactggtt      480

tgcacaggta cattcaggat cctaataaaa ttccagaaac actggacaat gatacaactc      540

agaatctatt aactaaagca gttgaaactt gctttgttgg acaaagcttt atttttggag      600

tgacgaattt tgaaaaccaa cctggacaag gttcagatgc cagtaacttc ttacagcaat      660

gctctgacca caaaagaaaa gccaaagcac tagtggcttg ccagattgtt ctaccagacc      720

caggtattgc aggctttact gtcattgact acttccatca acttttgcag acttttaatt      780

tcaggaaact tcagtgtgac tctcaggcac ctaacaatca cttacttgct ttagatcact      840

caaatagtga tctcagcagc atatatactt ctgacagcac ttctgatttt ttcaagtcct      900

gcagcaagga tactttttca aaattctggc agccatcact tgaattcact tgcattgttt      960

cacaactaac agataatgat gatttttcag cttcagaaca aagtaaggcc tttggtactc     1020

ttcagcagaa cagaaagtcc atctccattg cagaggccac tggttccagt agctgccatg     1080

atcccattca ggattcatgg agccttgttt catatatgga taaaaagagt acagcagaaa     1140

agttgggtaa agaacttggc ttacaagcta aggagctgag tgcagttcac agcagtcatc     1200

atgaaattgg agttaatgac tctaatttat tctctttgga aatgcgagag ccccttgagt     1260

caagtaatac aaaatccttc cacagtgcag tggaaattaa aaataggtcc cagcatgagc     1320

taccatgttt tcagcatcat ggtatagata ccccaactag ccttcagaag agatctgcat     1380

gttgtccacc ttcgttactc agacttgaag agacagccag cagttcccag gatggtgacc     1440

ctcaaatttg ggatgatctg ccattctctg aaagcctgaa caagtttctg gcagttcttg     1500

aaagtgagat tgctgtaacc caggcagatg tcagtagtag gaaacatcat gtagataatg     1560

acattgataa atttcatgca gaccacagca ggttatctgt gactccccag agaactactg     1620

gagccctgca tacaccacct atagctttaa gatcatcaca agtaatagtc aaagcaaact     1680

gtagcaaaga tgacttcctt ttcaactgta aaggaaatct aagtcctagt gttgaaaagg     1740

agtcacaacc agataacaaa gtagaggctg tctctgtaaa tcataatgga agagatatgt     1800

cagaatattt tttaccgaat ccttacctgt cagctctgtc ttcatcttca aaagatttag     1860

aaacaatagt tactcttaag aagactatca gaatctcacc acacagggag agtgaccatt     1920

ctagtctaaa taacaaatat ttgaatggat gtggagaaat atcagtttca gaaatgaatg     1980

aaaagttgac aactctgtgt tataggaagt ataatgatgt ctctgatctt tgcaaattag     2040

aaaataaaca atattgtagg tggtccaaga accaagatga cagttttaca atttgcagga     2100

aacttacata tcctttagaa actctttgca atagtccaaa tagaagtaca aatacattga     2160

aagaaatgcc ttggggacat atcaataaca acgtaacaca gagctattct attggttatg     2220

aaggtagcta tgatgcctct gctgatctct ttgatgatat tgctaaagaa atggacattg     2280

caactgagat taccaaaaaa tcacaggata ttttgttaaa atggggaaca tctttggcag     2340

aaagtcaccc ttcagagtct gatttttcac tgagatcact ttctgaagac ttcatccagc     2400

cttcacaaaa attatccttg caaagcctat ctgactctag gcattcaaga acatgctctc     2460

caacacctca ttttcaatca gattcagaat ataattttga aaatagtcaa gactttgttc     2520

catgttcaca gtcaactcca atttcagggt tccaccaaac aagaattcat gggataaaca     2580

gagctttcaa aaaacctgta ttttattcag atcttgatgg taactatgaa aaaataagga     2640

ttttccctga aaatgacaaa cagcaagcca gcccaagctg tccaaaaaat ataaaaacac     2700

ctagccagaa aatcagaagc cctattgtat ctggtgtttc acaaccagac gttttcaatc     2760

actacccttt tgctgagtgc catgaaactg atagtgatga atgggtccct cctaccacac     2820

aaaaaatatt tccttcagat atgcttggat tccaaggcat aggtctaggg aaatgccttg     2880

ctgcctatca tttccctgat caacaagagt taccaagaaa gaaactgaaa catattagac     2940

aaggaaccaa taaaggttta attaagaaga aattaaagaa tatgcttgca gcagttgtta     3000

cgaaaaagaa aactcataaa tataactgta aaagttcagg ctggatttcc aaatgtccag     3060

acattcaagt cttagcagca cctcagctgc accctattct tggacctgat tcttgttcag     3120

aagtcaaatg ttgccttcca ttttcagaaa aaggcccacc ttcagtgtgt gaaactcgaa     3180

gtgcttggtc acctgaattg ttttcataaa aagtcacctg aacccaattc ctgaactttt     3240

aaatctgttt ggaaatgttt gccttcaggg gtacggaaag cattctttac attttgaaca     3300

cttggagaga agcaaattga aaacaggact ctgctgggag ctactgtgcc ttttaaaata     3360

taaagccatt gttttcccca gggttttatc tagaatacta tgattaggta gttgagcact     3420

ttatcttata ctgtttattg tactttaata atattgttaa gattgttttt gaaagtatta     3480

atgtttgtta aaatcacata tacatccaga aataaagact ttgcaaacca aaa            3533


<210> 4139
<211> 570
<212> DNA
<213> Homo sapiens

<400> 4139
agttttgaaa atcatagttt tcgcccgcgc tgcgccgcct ggttgctcct cccgtgcgac       60

agagccacca tggggacgac ggccccaggg cccattcacc tgctggagct atgtgaccag      120

aagctcatgg agtttctctg caacatggat aataaggact tggtgtggct tgaggaaatc      180

caagaggagg ccgagcgcat gttcaccaga gaattcagca aagagccaga gctgatgccc      240

aaaacacctt ctcagaagaa ccgacggaag aagagacgga tttcttatgt tcaggatgaa      300

aacagagatc ccatcaggag aaggttatcc cgcagaaagt ctcggagcag ccagctgagc      360

tcccgacgcc tccgcagcaa ggacagtgta gagaagctgg ctacagtggt cggggagaac      420

ggctccgtcc tgcggcgtgt gacccgtgct gcggctgcag ctgccgcggc taccatggca      480

ttggctgcac cttcttcacc cacccctgag tctcccacga tgctgactaa gaagcccgag      540

gataaccaca cccagtgcca gctggtgcct                                       570


<210> 4140
<211> 2356
<212> DNA
<213> Homo sapiens

<400> 4140
tagcgccggg agtgggtgcc ttccgccggc tgtacagagc gccggcaggt ggcgcccagc       60

ggcgagcttg ttccagcttg gtttgggcca ggtggactgg aaggggcgga ggtaaccaga      120

agcggctagt ggcggctgcc tgcgtcccca accccctccg cgcagcgctc gcgacacgcg      180

tgccaggagt gggagcgagc ggcggggcca gctgcgttct gagcctgggc gcagctgcca      240

tctgctctgg gaagcaccag ggtgtccccg ccgccctcag ctcgaagtca gccaccatgg      300

aggcgcaggc acaaggtttg ttggagactg aaccgttgca aggaacagac gaagatgcag      360

tagccagtgc tgacttctct agcatgctct ctgaggagga aaaggaagag ttaaaagcag      420

agttagttca gctagaagac gaaattacaa cactacgaca agttttgtca gcgaaagaaa      480

ggcatctagt tgagataaaa caaaaactcg gcatgaacct gatgaatgaa ttaaaacaga      540

acttcagcaa aagctggcat gacatgcaga ctaccactgc ctacaagaaa acacatgaaa      600

ccctgagtca cgcagggcaa aaggcaactg cagctttcag caacgttgga acggccatca      660

gcaagaagtt cggagacatg agttactcca ttcgccattc cataagtatg cctgctatga      720

ggaattctcc tactttcaaa tcatttgagg agagggttga gacaactgtc acaagcctca      780

agacgaaagt aggcggtacg aaccctaatg gaggcagttt tgaggaggtc ctcagctcca      840

cggcccatgc cagtgcccag agcttggcag gaggctcccg gcggaccaag gaggaggagc      900

tgcagtgcta agtccagcca gcgtgcagct gcatccagaa accggccact acccagccca      960

tctctgcctg tgcttatcca gataagaaga ccaaaatccc gctgggaaaa acccaggcct     1020

tgacattgtt attcaaatgg cccctccaga aagtttaatg atttccattt gtatttgtgt     1080

tgatgatgga ccacttgacc atcacatttc agtattcata gatgactgtc acattttaaa     1140

atgttcccac ttgagcaggt acacaactgg tcataattcc tgtctgtgta attcgatgta     1200

tatttttcca aacatgtagc tattgtttgc tttgattttt gcttggcctc ctttatgatg     1260

tgcatgtcct tgaaggctga atgaacagtc cctttcagtt cagcagatca acaggatgga     1320

gctcttcatg actgtctcca gcaataggat gatttactat aaatttcatc caactacttg     1380

tgatctctct cacctacatc aattatgtat gttaatttca gcaattaaaa gaattgattt     1440

taatgacttt gaattcttaa tttctttgtc ttaaaagttg ctagttatga ttttacagat     1500

gcaattttaa atcaactttt agccaggtgc ggcggctcac acctgtaatc ccaactattt     1560

tggatgccaa ggtgagagga ttgcttgagg ccaggagtta aagatcagcc tgggcaacac     1620

agaccctgtc tctacaaaaa aagaaaaaaa ttagccagac atagtgttgc ttgcctgtag     1680

tcccagctac tctagaggct gaggcaggag gattgcatga gcctaggagt tcgaaactgc     1740

agtgagctat gattgcacca ctgcactact ccagcctggg tgacagagtg ggacactgtc     1800

tccaaaaata gtaataataa gtagtcaact tttactgcta atttggtgaa catgagagag     1860

gatatgaaaa taaatattac ctcagctatc ctaggatgtt aaaataatct ccaattttaa     1920

aattctctcc aatctacata cagtagtagt tagtcagata aaggatatcc aaaaaagaga     1980

tagctagaaa atgggagaag cagagttctg caaccccttt cagtttgtaa attgttcaca     2040

tgtatgaaaa taactggtat ttatcaatcc actcagattt ctgcactaac ttttatctta     2100

tatatcatat gtatctcttt tctttttcta aatgggaaca tatatttgtt attaggtggc     2160

agagatatag ccttaagata tatttgtaaa atgcacactg aatagacatc caacctaaaa     2220

aaaatcacta tttaaaaagc ccatataata tatacatatt tgttagcatg ctaattgttc     2280

atgttttgtg tttattaaat agaagtgata tatatgacat tttgaagtaa agcacatctg     2340

aaaaattcta ctcaaa                                                     2356


<210> 4141
<211> 1426
<212> DNA
<213> Homo sapiens

<400> 4141
gaaggtgggg ctatggcagc tgctagggac cctccggaag tatcgctgcg agaagccacc       60

cagcgaaaat tgcggaggtt ttccgagcta agaggcaaac ttgtagcacg tggagaattc      120

tgggacatag ttgcaataac agcggctgat gaaaaacagg aacttgctta caaccaacag      180

ctgtcagaaa agctgaaaag aaaggagtta ccccttggag ttcaatatca cgtttttgtg      240

gatcctgctg gagccaaaat tggaaatgga ggatcaacac tttgtgccct tcaatgtttg      300

gaaaagctat atggagataa atggaattct tttaccatct tattaattca ctctggtggc      360

tacagtcaac gacttccaaa tgcaagtgct ctgggaaaaa ttttcactgc tttacctctt      420

gatataccag aatgctctgg caaaacatcc tgtatcattc aaagcatact ggattcaaga      480

tgttctgtgg cacctggctc agttgtggag tattccagat tggggcctga tgtttcagtt      540

ggggaaaact gcattattag tggttcttac atcctaacaa aagctgccct ccccgcacat      600

tcttttgtat gttccttaag cttaaagatg aatagatgct taaagtatgc aactatggca      660

tttggagtgc aagacaactt gaaaaagagt gtgaaaacat tgtcagatat aaagttactt      720

caattctttg gagtctgttt cctgtcatgc ttagatgttt ggaatcttaa agttacagag      780

gaactgttct ctggtaacaa gacatgtctg agtttgtgga ctgcacgcat tttcccagtt      840

tgttcttctt tgagtgactc agttataaca tccctaaaga tgttaaatgc tgttaagaac      900

aagtcagcat tcagcctgaa tagctataag ttgctgtcca ttgaagaaat gcttatctac      960

aaagatgtag aagatatgat aacttacagg gaacaaattt ttctagaaat cagtttaaaa     1020

agcagtttga tgtagagata ttttaaatat tgtacacttt gcctttttga gtaacattcc     1080

agagataggt attttttgta ggctgtttca ctgaactcag ttaatgaaaa ctgtattaac     1140

ataattgttg tagcataata ttaatagtgc aaaagtacat ataagtcatt ttgatgaaaa     1200

atattccaag actaagttga gaaaagagat actattttgg atgtgtatca gtatttttgt     1260

ttttaataat gattgatttg tggagcattg ttttttcaca taattagttt taaaggtaat     1320

tttctaagca tacctttgga atttttccat cttttttgag gcttttggtc cagtgaagtt     1380

ctaagtattc actggcactt ctctcctcaa ctgtaattct attttt                    1426


<210> 4142
<211> 943
<212> DNA
<213> Homo sapiens

<400> 4142
tcggctttct tctcgtcggt gttcccggct gctatagagc cgggtccccg cggaagccgc       60

ggtgtcggcg ccatggcgga gctgacggct cttgagagtc tcatcgagat gggcttcccc      120

aggggacgcg cggagaaggc tctggccctc acagggaacc agggcatcga ggctgcgatg      180

gactggctga tggagcacga agacgacccc gatgtggacg agcctttaga gactcccctt      240

ggacatatcc tgggacggga gcccacttcc tcagagcaag gcggccttga aggatctggt      300

tctgctgccg gagaaggcaa acccgctttg agtgaagagg aaagacagga acaaactaag      360

aggatgttgg agctggtggc ccagaagcag cgggagcgtg aagaaagaga ggaacgggag      420

gcattggaac gggaacggca gcgcaggaga caagggcaag agttgtcagc agcacgacag      480

cggctacagg aagatgagat gcgccgggct gctgaggaga ggcggaggga aaaggccgag      540

gagttagcag ccagacaaag agttagagaa aagatcgaga gggacaaagc agagagagcc      600

aagaagtatg gtggcagtgt gggctctcag ccacccccag tggcaccaga gccaggtcct      660

gttccctctt ctcccagcca ggagcctccc accaagcggg agtatgacca gtgtcgcata      720

caggtcaggc tgccagatgg gacctcactg acccagacgt tccgggcccg ggaacagctg      780

gcagctgtga ggctctatgt ggagctccac cgtggggagg aactaggtgg gggccaggac      840

cctgtgcaat tgctcagtgg cttccccaga cgggccttct cagaagctga catggagcgg      900

cctctgcagg agctgggact cgtgccttct gctgttctca ttg                        943


<210> 4143
<211> 811
<212> DNA
<213> Homo sapiens

<400> 4143
gcggcttgtg gctcccaagt tagggagtga gaggatcgcc cgccgagggg gtggctccgc       60

agcccggctg cgcgagacgc ttcccgctcg gggacccgcc ttccgaggcc aggtgaacgt      120

taccggcccc ctgacctcca gcagatccac acgtttgttg gagactgaac cgttgcaagg      180

aacagacgaa gatgcagtag ccagtgctga cttctctagc atgctctctg aggaggaaaa      240

ggaagagtta aaagcagagt tagttcagct agaagacgaa attacaacac tacgacaagt      300

tttgtcagcg aaagaaaggc atctagttga gataaaacaa aaactcggca tgaacctgat      360

gaatgaatta aaacagaact tcagcaaaag ctggcatgac atgcagacta ccactgccta      420

caagaaaaca catgaaaccc tgagtcacgc agggcaaaag gcaactgcag ctttcagcaa      480

cgttggaacg gccatcagca agaagttcgg agacatgaga cgaaagtagg cggtacgaac      540

cctaatggag gcagttttga ggaggtcctc agctccacgg cccatgccag tgcccagagc      600

ttggcaggag gctcccggcg gaccaaggag gaggagctgc agtgctaagt ccagccagcg      660

tgcagctgca tccagaaacc ggccactacc cagcccatct ctgcctgtgc ttatccagat      720

aagaagacca aaatcccgct gggaaaaacc caggccttga cattgttatt caaatggccc      780

ctccagaaag tttaatgatt tccatttgta t                                     811


<210> 4144
<211> 684
<212> DNA
<213> Homo sapiens

<400> 4144
gccattctcc tgcctcagcc tcctgagtag ctgggactac aggtgcccgc caccaggccc       60

ggctaatttt ttgtattttt agtagaggcg gggttttgca gtgttaacca ggatggtctc      120

gatctcctga ccttgtgatc agcccacctt ggcctcccaa agtgctggga ttacaggctt      180

gagccaccgc gcctggccca gcttttcttt tattagatag caatgaggat gggatccgaa      240

gtagagcttc caacgaccct caggagcgct gagcgaccaa gtgaagtacc tacaggaccc      300

atttgtgttc actgatctat tggagcagct ggggattgtg gtttgttgga gactgaaccg      360

ttgcaaggaa cagacgaaga tgcagtagcc agtgctgact tctctagcat gctctctgag      420

gaggaaaagg aagagttaaa agcagagtta gttcagctag aagacgaaat tacaacacta      480

cgacaagttt tgtcagcgaa agaaaggcat ctagttgaga taaaacaaaa actcggcatg      540

aacctgatga atgaattaaa acagaacttc agcaaaagct ggcatgacat gcagactacc      600

actgcctaca agaaaacaca tgaaaccctg agtcacgcag ggcaaaaggc aactgcagct      660

ttcagcaacg ttggaacggc catc                                             684


<210> 4145
<211> 4189
<212> DNA
<213> Homo sapiens

<400> 4145
cgcgggcggc ggtgctaggc tcgcctctgc ctccctcgtg gcgggcccgg acatggggtc       60

ccgtggcctg agtccctcgg ccggcgcgca gggctcgggg ccgcgcgcag cctccccgca      120

ctgactgtcg cgccgtgccc tgcgccagga ggagcggagg ccgcgcgcgg cccgccgagc      180

gccttcagga tgctcatcaa ggaataccac attctgctgc ccatgagcct ggacgagtac      240

caggtggccc agctctacat gatccagaaa aagagccggg aggagtctag tggtgagggc      300

agcggcgtgg agatcctggc caaccggccc tacacggatg ggcccggggg cagcgggcaa      360

tacacacaca aggtgtacca cgtgggctcc cacatcccag gctggttccg ggcactgctg      420

cccaaggctg ccctgcaggt agaagaggaa tcctggaatg cctaccccta cacccgaacc      480

cggtacacct gccctttcgt ggagaaattc tccattgaaa ttgagaccta ttacctgcct      540

gatggggggc agcagccaaa cgtcttcaac ctgagcgggg ccgagaggag acagcgcatc      600

ctggacacca tcgacatcgt gcgggatgca gtggccccag gcgagtacaa agcagaagag      660

gacccccggc tttatcactc ggtcaagacg ggccgagggc cactgtctga tgactgggca      720

cggacggcgg cacagacggg gccccttatg tgtgcctata agctgtgcaa ggttgagttc      780

cgctactggg gcatgcaagc caagatcgag cagttcatcc atgatgtagg tctgcgtcgg      840

gtgatgctgc gggcccaccg ccaggcctgg tgctggcagg atgagtggac agagctgagc      900

atggctgaca tccgggcact ggaagaggag actgctcgca tgctggccca gcgcatggcc      960

aagtgcaaca caggcagtga ggggtccgag gcccagcccc ccgggaaacc gagcaccgag     1020

gcccggtctg cggccagcaa cactggcacc cccgatgggc ctgaggcccc cccaggccca     1080

gatgcctccc ccgatgccag ctttgggaag cagtggtcct catcctcccg ttcctcctac     1140

tcatcccaac atggaggggc tgtgtctccc cagagcttgt ctgagtggcg catgcagaac     1200

attgcccgag actctgagaa cagctccgag gaagagttct ttgatgccca cgaaggcttc     1260

tcggacagtg aggaggtctt ccccaaggag atgaccaagt ggaactccaa tgacttcatt     1320

gatgcctttg cctccccagt ggaggcagag ggaacgccag agcctggagc cgaggcagct     1380

aaaggcattg aggatggggc ccaagcaccc agggactcag agggcctgga tggagccggg     1440

gagctggggg ctgaggcatg cgcagtccac gccctcttcc ttatcctgca cagcggcaac     1500

atcctggact caggccctgg agacgccaac tccaagcagg cggatgtgca gacgctgagc     1560

tccgccttcg aggccgtcac ccgcatccac ttccctgagg ccttgggcca cgtggcgctg     1620

cgactggtgc cctgtccacc catctgcgcc gccgcctatg cccttgtctc caacctgagc     1680

ccttacagcc acgatgggga cagcctgtct cgctcccaag accacattcc actggctgcc     1740

ctgccactgc tggccacctc atcctcccgc taccagggcg ccgtggccac cgtcattgcc     1800

cgcaccaacc aggcctactc agccttcctg cgctcacctg agggtgccgg cttctgtggg     1860

caggtcgcac tgattggaga tggtgttggt ggcatcctgg gctttgatgc actctgccac     1920

agtgctaacg cgggcaccgg gagtcggggc agcagccgcc gtgggagcat gaacaatgag     1980

ctgctctctc cggagtttgg cccagtgcgg gaccccctgg cagatggtgt ggaaggcctg     2040

ggtcggggca gcccagaacc ctcggccttg cctccccagc gcatccccag cgacatggcc     2100

agtcctgagc ccgagggctc tcagaacagc cttcaggcag cccccgcaac cacctcctcc     2160

tgggagcccc ggcgggcaag cacggccttc tgcccacccg ctgccagttc cgaggcacct     2220

gacggcccca gcagcactgc ccgccttgac ttcaaggtct ctggcttctt cctcttcggc     2280

tccccactgg gcctggtgct ggctctgcgc aaaactgtga tgcccgccct ggaggcagcc     2340

cagatgcgcc cagcctgtga acagatctac aacctcttcc acgcggctga cccctgcgcc     2400

tcacgcctcg agcccctgct ggccccgaag ttccaggcca tcgccccact gaccgtgccc     2460

cgctaccaga agttccccct gggagatggc tcatccctgc tgctggccga cactctgcag     2520

acgcactcca gcctctttct ggaggagctg gagatgctgg tgccctcaac acccacctct     2580

actagcggtg ccttctggaa gggcagtgag ttggccactg accccccggc ccagccagcc     2640

gcccccagca ccaccagtga ggtggttaag atcctggagc gctggtgggg gaccaagcgg     2700

atcgactact cgctgtactg ccccgaggcg ctcaccgcct ttcccaccgt cacgctgccc     2760

cacctcttcc acgccagcta ctgggagtcc gccgacgtgg tggcgttcat cctgcgccag     2820

gtgatcgaga aggagcggcc acagctggcg gaatgcgagg agccgtccat ctacagcccg     2880

gccttcccca gggagaagtg gcagcgaaaa cgcacgcagg tcaagatccg gaacgtcact     2940

tccaaccacc gggcgagcga cacggtggtg tgcgagggcc gcccccaggt gctaagcggg     3000

cgcttcatgt acgggcccct ggacgtcgtc acgctcactg gagagaaggt ggatgtctac     3060

atcatgacgc agccgctgtc gggcaagtgg atccactttg gcaccgaagt caccaatagc     3120

tcgggccgcc tcaccttccc agttccccca gaacgcgcgc tgggcattgg tgtctacccc     3180

gtgcgcatgg tggtcagggg cgaccacacc tatgccgaat gctgcctgac tgtggtggcc     3240

cgcggcacgg aggctgtggt cttcagcatc gacggctcct tcaccgccag cgtctccatc     3300

atgggcagcg accccaaggt gcgagctggc gccgtggacg tggtcaggca ctggcaggac     3360

tccggctacc tgatcgtgta tgtcacaggc cggccggata tgcagaagca ccgcgtggtg     3420

gcatggctgt cgcagcacaa cttcccccac ggcgtcgtct ccttctgcga cggcctcacc     3480

cacgacccac tacgccagaa ggcaatgttt ctgcagagcc tggtgcagga ggtagaactg     3540

aacatcgtgg ccggttatgg gtctcccaaa gatgtggctg tatacgcggc gctggggctg     3600

tccccgagcc agacctacat cgtgggccgt gccgtgcgga agctacaggc gcagtgccag     3660

ttcctgtcag acggctatgt ggcccacctg ggccagctgg aagcgggctc gcactcgcat     3720

gcctcctcgg gacccccgag agctgccttg ggcaagagca gctatggtgt ggctgccccc     3780

gtggacttcc tgcgcaaaca gagccagctg cttcgctcga ggggccccag ccaggcggag     3840

cgtgagggcc cgggaacacc acccaccacc ctggcacggg gcaaagcacg gagcatcagc     3900

ctgaagctgg acagcgagga gtgaggccca caccagcctg gacctgggtt atttattgac     3960

acacccaagg ggcccgaggg gctgcgtgtg ggaggctggg gacccagact tttggcccca     4020

gcgctggccc ccccagcccc acaccctata tctccgtgtg ctcctcggtg ttacttccct     4080

ttcatatgag gggacccagc gccgggggga gggaggaggg cgtgggcatg ggcgcagagg     4140

cttttccagt gtgtataaat ccatgaaaat aaacgccacc tgcacccca                 4189


<210> 4146
<211> 2936
<212> DNA
<213> Homo sapiens

<400> 4146
aaacggagcc cttaaagggc aatgctctgc gtgtgccacg gtgcccaaca gcatctcgtg       60

ccagctgagc tgcggtgtgt ggacccgggg aatggaccgg gctggacaac ctctaagact      120

tggctccagc tcagcctgtg aaggaatcac ctctctgatc cccacctctg ccccggagtg      180

ctagacccag ggaggaagag accccatgga ccagccagag gccccctgct ccagcacggg      240

gccgcgcctc gcggtggccc gcgagctgct cctggctgcg ctggaggaac tgagccaaga      300

gcagctgaag cgcttccgcc acaagctgcg cgacgtgggc ccggacggac gcagcatccc      360

gtgggggcgg ctggagcgcg cggacgccgt ggacctcgcg gagcagctgg cccagttcta      420

cggcccggag cctgccctgg aggtggcccg caagaccctc aagagggcgg acgcgcgcga      480

cgtggcggcg cagctccagg agcggcggct gcagcggctc gggctcggct ccgggacgct      540

gctctccgtg tccgagtaca agaagaagta ccgggagcac gtgctgcagc tgcacgctcg      600

ggtgaaggag aggaacgccc gctccgtgaa gatcaccaag cgcttcacca agctgctcat      660

cgcgcccgag agcgccgccc cggaggaggc gatggggccc gcggaagagc ctgagccggg      720

gcgcgcgcgg cgctcggaca cgcacacttt caaccgcctc ttccgccgcg acgaggaggg      780

ccggcggccg ctgaccgtgg tgctgcaggg cccggcgggc atcggcaaga ccatggcggc      840

caaaaagatc ctgtacgact gggcggcggg caagctgtac cagggccagg tggacttcgc      900

cttcttcatg ccctgcggcg agctgctgga gaggccgggc acgcgcagcc tggctgacct      960

gatcctggac cagtgccccg accgcggcgc gccggtgccg cagatgctgg cccagccgca     1020

gcggctgctc ttcatcctgg acggcgcgga cgagctgccg gcgctggggg gccccgaggc     1080

cgcgccctgc acagacccct tcgaggcggc gagcggcgcg cgggtgctag gcgggctgct     1140

gagcaaggcg ctgctgccca cggccctcct gctggtgacc acgcgcgccg ccgcccccgg     1200

gaggctgcag ggccgcctgt gttccccgca gtgcgccgag gtgcgcggct tctccgacaa     1260

ggacaagaag aagtatttct acaagtattt ccgggatgag aggagggccg agcgcgccta     1320

ccgcttcgtg aaggagaacg agacgctgtt cgcgctgtgc ttcgtgccct tcgtgtgctg     1380

gatcgtgtgc accgtgctgc gccagcagct ggagctcggt cgggacctgt cgcgcacgtc     1440

caagaccacc acgtcagtgt acctgctttt catcaccagc gttctgagct cggctccggt     1500

agccgacggg ccccggttgc agggcgacct gcgcaatctg tgccgcctgg cccgcgaggg     1560

cgtcctcgga cgcagggcgc agtttgccga gaaggaactg gagcaactgg agcttcgtgg     1620

ctccaaagtg cagacgctgt ttctcagcaa aaaggagctg ccgggcgtgc tggagacaga     1680

ggtcacctac cagttcatcg accagagctt ccaggagttc ctcgcggcac tgtcctacct     1740

gctggaggac ggcggggtgc ccaggaccgc ggctggcggc gttgggacac tcctgcgtgg     1800

ggacgcccag ccgcacagcc acttggtgct caccacgcgc ttcctcttcg gactgctgag     1860

cgcggagcgg atgcgcgaca tcgagcgcca cttcggctgc atggtttcag agcgtgtgaa     1920

gcaggaggcc ctgcggtggg tgcagggaca gggacagggc tgccccggag tggcaccaga     1980

ggtgaccgag ggggccaaag ggctcgagga caccgaagag ccagaggagg aggaggaggg     2040

agaggagccc aactacccac tggagttgct gtactgcctg tacgagacgc aggaggacgc     2100

gtttgtgcgc caagccctgt gccggttccc ggagctggcg ctgcagcgag tgcgcttctg     2160

ccgcatggac gtggctgttc tgagctactg cgtgaggtgc tgccctgctg gacaggcact     2220

gcggctgatc agctgcagat tggttgctgc gcaggagaag aagaagaaga gcctggggaa     2280

gcggctccag gccagcctgg gtggcggcag ttctcaaggc accacaaaac aactgccagc     2340

ctcccttctt catccactct ttcaggcaat gactgaccca ctgtgccatc tgagcagcct     2400

cacgctgtcc cactgcaaac tccctgacgc ggtctgccga gacctttctg aggccctgag     2460

ggcagccccc gcactgacgg agctgggcct cctccacaac aggctcagtg aggcgggact     2520

gcgtatgctg agtgagggcc tagcctggcc gcagtgcagg gtgcagacgg tcagggtaca     2580

gctgcctgac ccccagcgag ggctccagta cctggtgggt atgcttcggc agagccctgc     2640

cctgaccacc ctggatctca gcggctgcca actgcccgcc cccatggtga cctacctgtg     2700

tgcagtcctg cagcaccagg gatgcggcct gcagaccctc agtctggcct ctgtggagct     2760

gagcgagcag tcactacagg agcttcaggc tgtgaagaga gcaaagccgg atctggtcat     2820

cacacaccca gcgctggacg gccacccaca acctcccaag gaactcatct cgaccttctg     2880

aggctctggt ggccagagca gggtggaaga ccctagtcaa agtccctgtg gagaga         2936


<210> 4147
<211> 474
<212> DNA
<213> Homo sapiens

<400> 4147
gagacctggc gccccggccg aggcgcgaac agacggacgc accggcgagc gccgagggga       60

caggccgagc gcggggcgcc ggaggcagtc cctcccctag gcttggctgc tgccaggggt      120

tctgcgctgg ccacctggcc gcatccctgc cctcgaggtg tgggacaggc actggcctca      180

gaccggggcc acactgaggt ctgcccttct cccgctggcc gccacccaag acaccatgag      240

ccagtccggg gccgtgagct gctgcccggg tgccaccaat ggcagcctgg gccggtccga      300

cggtgtggcc aagatgagcc ccaaggacct gtttgagcag aggaagaagt attccaactc      360

caacgtcatc atgcacgaga cctcgcagta ccacgtccag cacctggcca cattcatcat      420

ggacaagagc gaagccatca cgtctgtgga cgacgccatc cggaagctgg tgca            474


<210> 4148
<211> 2076
<212> DNA
<213> Homo sapiens

<400> 4148
attatcctcc ttattgacaa acagagcggt cgcggcggcg actctcggcg tgcggtgata       60

gccaagccat gggagacaag aagagcccca ccaggccgaa gcggcagccg aagccgtcct      120

cggatgaggg ttactgggac tgtagcgtct gcaccttccg gaacagcgcc gaggccttca      180

agtgcatgat gtgcgatgtg cggaagggca cctccacccg gaaacctcga cctgtctccc      240

agttggttgc acagcaggtt actcagcagt ttgtgcctcc tacacagtca aagaaagaga      300

aaaaagataa agtagaaaaa gaaaaaagtg aaaaggaaac aactagcaaa aagaatagcc      360

ataagaaaac caggccaaga ttgaaaaatg tggatcggag tagtgctcag catttggaag      420

ttactgttgg agatctgaca gtcattatta cagactttaa ggagaaaaca aagtcaccgc      480

ctgcatctag tgctgcttct gcagatcaac acagtcaaag cggctctagc tctgataaca      540

cagagagagg aatgtccagg tcatcttcac ccagaggaga agcctcatca ttgaatggag      600

aatctcatta aagtttattt tctccaattt cttagtcact tctgtcctac catgcaaata      660

cacagattat gccaagaggt accacatttt catgacagat acattcatgc acaatccata      720

atttgagttt tacataaaat agaaatttgt tagaatttgt tagattttat tgcaatgatg      780

cctaccaaac atttccagac ttaacatttt ggtctctgca gttaagtgcc atgaaaatgt      840

ggttgaatta ttcattatgc agtgttattg gtaagtgtat tttcactttt agtttagtga      900

attctaacac ataattcttg aattctctac tattggcatg taacgaattt aaatttttta      960

taacatagtg caagctgcct aaatatgtat tatttgagaa ttgtgaaaca gatagttata     1020

tgtatacaag tcaaagaaca acttaactat tgctgcaaca ggtttttctt aatggttatc     1080

ctcttaaata cacctgctgg tacttggtgt ggttaaatag gaaaattgtt attaaataaa     1140

gaatttgtat gaacctttgc caatgttttt gacacgtttt actaattatt gttcctgaat     1200

tatgtttctg gttttatcta ttttttgagg tttttttgtt tgcttatttt tcaaaacatt     1260

catttattgt aatgtttact agcggactag taaacaataa aacattgatt atttagcttt     1320

ataattcagg tttagtgcta ttgtcattga acactggtat tttctgtatc atataaaaca     1380

ttaaaattca aataattata agcatttggc aaaaacaaga gaaaagaaac ttgccatatt     1440

ttacaagctg caattttaga aaagctttaa cttaatgata gttttatcat tgttttcttg     1500

tcccaaactt atccagggcc atagaagtat gaatctaatt aaaacagaaa tgggaattat     1560

tgcacagaaa tgggaaataa ctaattttaa atcagtcaaa ttggcttctt attaaataca     1620

ataattctta tgaaaatcat agtaccctat tttcagacac agctgccagt ttacacattt     1680

ctcagtatcc tgaaaggaaa aaagtatagc cccacttata ctatgtaaaa ttaccaataa     1740

aatattttta tgactacaga ttttgcattt ttgtttacaa ctatttaaag agttttatgt     1800

tgtatttaga atttcaacct agaaaccaca cagtacttaa attctcctgg ggtctcctgc     1860

tttctcttaa ccatttgctt aatatatatc tacctaaagg agacttctga attgtaaatg     1920

aacttaaaaa tagaatgtgg atgcaaaata tcacataaga catcatgata acatttgaag     1980

aaaaaataaa actgtagacc ctaacagttg tgatatttgg tggtttcatg tggtaatgta     2040

attttctgtt taattacagt actttttaca ggcaca                               2076


<210> 4149
<211> 3335
<212> DNA
<213> Homo sapiens

<400> 4149
cacaggagtc ctggctgagc tcatggcctg aggctgccta gcggccacgg ggaatggttg       60

caatggcgga ggcagaggca ggggtggcag tggaggtccg tggactgccc cctgccgtgc      120

ccgacgagct gctcactctc tactttgaaa accgccgacg ctctggaggg ggacctgtgt      180

tgagctggca gagactgggc tgtgggggcg tcctcacctt cagagagcct gcagacgccg      240

agagggtctt ggcccaggca gatcacgaac tacatggtgc ccagtacagc cttgctgtgc      300

cttggccagc ccccggccag accgggctct ggtccagttg cccaagcccc tttctgaggc      360

agatgtccgt gtcctggagg agcaggccca gaatctgggc ctggagggga ccttggtgtc      420

cctggcccgg gttccccagg cccgagcggt gcgtgtggtg ggggatggtg cctctgtgga      480

cctgctgttg ctggagttgt acctggagaa tgagcgccgc agtggtgggg ggcccctgga      540

ggacctgcaa cgcctacccg ggcccctggg cactgttgcc tccttccagc agtggcaagt      600

ggcagaacga gtgttgcagc aggagcaccg gttgcagggc tcagagctga gccttgtccc      660

ccactacgac atcctggagc ccgaggagct ggctgagaac accagtggag gggaccaccc      720

gtccacccag gggcctaggg ctaccaagca tgctctcctg aggaccggag ggttggtgac      780

ggctctgcag ggtgcaggga ctgtgacaat gggctctggc gaggaaccag ggcagtcagg      840

ggcctctctg aggacaggtc ccatggtgca gggtagaggg attatgacaa caggctctgg      900

ccaggaacca gggcagtcag ggacctctct gaggacaggt cccatggggt ctctgggaca      960

ggcagagcaa gtcagctcga tgcccatggg gtctctggaa catgaggggc tggtaagcct     1020

gaggcctgtg gggttgcagg aacaggaggg gcccatgagc ctggggcctg tggggtctgc     1080

aggcccagtg gagacctcta aggggttgct ggggcaggag ggcctggtgg aaattgccat     1140

ggactcacca gagcaagagg ggctggtggg tcccatggag atcaccatgg ggtctctgga     1200

gaaggcaggg cctgtgagcc caggatgtgt gaagctggca gggcaggagg gcctggtgga     1260

gatggtgcta ttgatggagc caggggcgat gcgcttcctg cagctctacc atgaggacct     1320

tcttgcgggc ctgggagacg tcgctctctt gccacttgaa ggaccggata tgactggctt     1380

tcggctctgt ggagcccagg cttcctgcca ggcggctgag gagtttctgc ggagcctgct     1440

gggcagcatt agctgccatg tgttgtgcct ggagcacccg ggcagcgcca ggtttctcct     1500

gggcccagaa gggcagcacc ttctccaggg gctggaggct cagttccagt gtgtctttgg     1560

gacagagcgc ctggccacag ccacgttgga cacaggcctt gaagaggtgg accctaccga     1620

ggccctccca gtgctccctg gcaacgccca caccctgtgg accccagaca gtacaggtgg     1680

tgaccaggag gacgtgagcc tggaggaggt ccgagaactg ctggccaccc tggagggcct     1740

agacctagac ggggaggact ggctgcctcg ggagctggag gaggaagggc ctcaggagca     1800

gccagaggag gaggtgaccc cagggcatga ggaggaggag cctgtggccc ccagcactgt     1860

ggcacccagg tggctggagg aggaggccgc tctgcagctg gccctccacc ggtcactgga     1920

gcctcaaggt caggtggctg agcaggagga ggctgctgcc ctgcggcaag ccctaaccct     1980

ctccctgctg gagcagcccc cgttggaggc agaagagccc ccagatgggg ggactgatgg     2040

caaggcccag ctggtggtgc actcggcctt tgagcaggat gtggaggagc tggaccgggc     2100

gctcagggct gccttggagg tccacgtcca ggaggagacg gtggggccct ggcgccgcac     2160

actgcctgca gagctgcgtg ctcgcctgga gcggtgccat ggtgtgagtg ttgccctgcg     2220

tggtgactgc accatcctcc gtggcttcgg ggcccaccct gcccgtgctg cccgccactt     2280

ggtggcactt ctggctggcc cctgggatca gagtttggcc tttcccttgg cagcttcagg     2340

ccctaccttg gcggggcaga cgctgaaggg gccctggaac aacctggagc gtctggcaga     2400

gaacaccggg gagttccagg aggtggtgcg ggccttctac gacaccctgg acgctgcccg     2460

cagcagcatc cgcgtcgttc gtgtggagcg cgtgtcgcac ccgctgctgc agcagcagta     2520

tgagctgtac cgggagcgcc tgctgcagcg atgcgagcgg cgcccggtgg agcaggtgct     2580

gtaccacggc acgacggcac cggcagtgcc tgacatctgc gcccacggct tcaaccgcag     2640

cttctgcggc cgcaacgcca cggtctacgg gaagggcgtg tatttcgcca ggcgcgcctc     2700

cctgtcggtg caggaccgct actcgccccc caacgccgat ggccataagg cggtgttcgt     2760

ggcacgggtg ctgactggcg actacgggca gggccgccgc ggtctgcggg cgccccctct     2820

gcggggtcct ggccacgtgc tcctgcgcta cgacagcgcc gtggactgca tctgccagcc     2880

cagcatcttc gtcatcttcc acgacaccca ggcgctgccc acccacctca tcacctgcga     2940

gcacgtgccc cgcgcttccc ccgacgaccc ctctgggctc ccgggccgct ccccagacac     3000

ttaaccgaag gggccaccct ctggcctcct gcttcccagg ctcccagctc cgcacaggct     3060

gatgctcccc gcccccaact gtggccgcct gagctgtccc cggggacgcc cctgcctccc     3120

tctgcgggct ccagaaggcg gtgtggggga tggcggtcag cagcggccga ggggggccgg     3180

gctaggtccc agcctgggcc gaccccacca ccaggggtca gcagagccca ggaggcgaca     3240

ccgcccgccc gccgctccca gacctcgccc gagtcggctc tgttgtttga ataaacgtga     3300

acgtgaaccc aggcggaagg gacccgggaa ctctg                                3335


<210> 4150
<211> 1224
<212> DNA
<213> Homo sapiens

<400> 4150
caacggaccc tacctcttgt agtgattctc ggggccacgg gcaccggcaa atccacgctg       60

gcgttgcagc taggccagcg gctcggcggt gagatcgtca gcgctgactc catgcaggtc      120

tatgaaggcc tagacatcat caccaacaag gtttctgccc aagagcagag aatctgccgg      180

caccacatga tcagctttgt ggatcctctt gtgaccaatt acacagtggt ggacttcaga      240

aatagagcaa ctgctctgat atatttgccc gagacaaaat tcctattgtt gtgggaggaa      300

ccaattatta cattgaatct ctgctctgga aagttcttgt caataccaag gagcttgcaa      360

gtttttgaag aaacaggaat ctctcatagt gaatttctcc atcgtcaaca tacggaagaa      420

ggtggtggtc cccttggagg tcctctgaag ttctctaacc cttgcatcct ttggcttcat      480

gctgaccagg cagttctaga tgagcgcttg gataagaggg tggatgacat gcttgctgct      540

gggctcttgg aggaactaag agattttcac agacgctata atcagaagaa tgtttcggaa      600

aatagccagg actatcaaca tggtatcttc caatcaattg gcttcaagga atttcacgag      660

tacctgatca ctgagggaaa atgcacactg gagactagta accagcttct aaagaaaggt      720

attgaggctc tgaaacaagt aactaagaga tatgcccgga aacaaaaccg atgggttaaa      780

aaccgttttt tgagcagacc tggtcccatt gtcccccctg tctatggctt agaggtatct      840

gatgtctcga agtgggaaga gtctgttctt gaacctgctc ttgaaatcgt gcaaagtttc      900

atccagggcc acaagcctac agccactcca ataaagatgc catacaatga agctgagaac      960

aagagaagtt atcacctgtg tgacctctgt gatcgaatca tcattgggga tcgcgaatgg     1020

gcagcgcaca taaaatccaa atcccacttg aaccaactga agaaaagaag aagattggac     1080

tcagatgctg tcaacaccat agaaagtcag agtgtttccc cagaccataa caaagaacct     1140

aaagagaagg gatccccagg gcagaatgat caagagctga aatgcagcgt ttaagagaca     1200

tgtccagtgg cctttggaaa ggtg                                            1224


<210> 4151
<211> 1707
<212> DNA
<213> Homo sapiens

<400> 4151
gcagcaatgg agagctgagg gagcgtcgtc aggctctgga catcctgagc ccaagtcccc       60

cacactcagt gcagtgatga gtgcggaagt gaaggtgaca gggcagaacc aggagcaatt      120

tctgctccta gccaagtcgg ccaagggggc agcgctggcc acactcatcc atcaggtgct      180

ggaggcccct ggtgtctacg tgtttggaga actgctggac atgcccaatg ttagagagct      240

ggctgagagt gactttgcct ctaccttccg gctgctcaca gtgtttgctt atgggacata      300

cgctgactac ttagctgaag cccggaatct tcctccacta acagaggctc agaagaataa      360

gcttcgacac ctctcagttg tcaccctggc tgctaaagta aagtgtatcc catatgcagt      420

gttgctggag gctcttgccc tgcgtaatgt gcggcagctg gaagaccttg tgattgaggc      480

tgtgtatgct gacgtgcttc gtggctccct ggaccagcgc aaccagcggc tcgaggttga      540

ctacagcatc gggcgggaca tccagcgcca ggacctcagt gccattgccc gaaccctgca      600

ggaatggtgt gtgggctgtg aggtcgtgct gtcaggcatt gaggagcagg tgagccgtgc      660

caaccaacac aaggagcagc agctgggcct gaagcagcag attgagagtg aggttgccaa      720

ccttaaaaaa accattaaag ttacgacggc agcagcagcc gcagccacat ctcaggaccc      780

tgagcaacac ctgactgagc tgagggaacc agctcctggc accaaccagc gccagcccag      840

caagaaagcc tcaaagggca aggggctccg agggagcgcc aagatttggt ccaagtcgaa      900

ttgaaaggac tgtcgtttcc tccctgggga tgtggggtcc cagctgcctg cctgcctctt      960

aggagtcctc agagagcctt ctgtgcccct ggccagctga taatcctagg ttcatgaccc     1020

ttcacctccc ctaaccccaa acatagatca caccttctct agggaggagg caaatgtagg     1080

tcatgttttt gttggtactt tctgtttttt gtgacttcat gtgttccatt gctccccgct     1140

gccatgctct ctcccttgtt tccttaagag ctcagcatct gtccctgttc attacatgtc     1200

attgagtagg tgggtagccc tgatgggggt cgctctgtct ggagcataac ccacaggcgt     1260

tttttctgcc accccatccc tgcatgcctg atccccagtt cctataccct acccctgacc     1320

tattgagcag cctctgaaga gccatagggc ccccaccttt actcacaccc tgagaattct     1380

gggagccagt ctgccatgcc aggagtcact ggacatgttc atcctagaat cctgtcacac     1440

tacagtcatt tcttttcctc tctctggccc ttgggtcctg ggaatgctgc tgcttcaacc     1500

ccagagccta agaatggcag ccgtttctta acatgttgag agatgattct ttcttggccc     1560

tggccatctc gggaagcttg atggcaatcc tggaagggtt taatctcctt ttgtgagttt     1620

ggtggggaag ggaagggtat atagattgta ttaaaaaaaa aaaggtatat atgcatatat     1680

ctatatataa tatgacgcag aaataaa                                         1707


<210> 4152
<211> 2048
<212> DNA
<213> Homo sapiens

<400> 4152
atctccactc ccctcccacc aggcacgagg acatccccat ccccacgcca ctcgcaccgg       60

gtccgcgggg aaccccctat ctctaccttc cccgacgcgg ctcccacaag acccccatct      120

ctgcgccggg cccctccacg tgcggggtct caggtttgag gtggtcccct ccaagtttaa      180

agagaagctg gacaaagcct ccttcgctac tccgtatggg tacgccatgg agaccgccaa      240

gcagaaggcc ctggaggtgg ccaaccggct gtaccagaaa gacctgcggg cccccgacgt      300

ggtcattgga gcggacacga tcgtgacagt cggggggctg attctggaga agccggtgga      360

caagcaggac gcctacagga tgctgtcccg gttgagtggg agagaacaca gcgtgttcac      420

aggtgtcgcg atcgtccact gctccagcaa agaccatcag ctggacacca gggtctcgga      480

attctacgag gaaacgaagg tgaagttctc ggagctgtcc gaggagctgc tctgggaata      540

cgtccacagc ggggagccca tggacaaagc tggcggctac gggatccagg ccctgggcgg      600

catgctggtg gagtccgtac acggggactt tctgaacgtg gtgggattcc cgctgaacca      660

cttctgcaag cagctggtga agctctacta cccgccccgt ccggaggacc tgcggcggag      720

tgtcaagcac gactccatcc cggccgcgga caccttcgaa gacctcagtg acgtggaggg      780

gggcggctcg gagcccactc agagggacgc gggcagccgc gatgagaagg ccgaggcggg      840

agaggcggga caggccacgg cagaggctga gtgtcacagg actcgggaga ccctgcctcc      900

gttcccgaca cgcctcctgg agctgattga gggctttatg ctatccaagg gcctgctcac      960

cgcttgcaaa ctgaaggtgt tcgatttgtt aaaagatgaa gcaccccaga aggctgcgga     1020

tattgccagc aaagtggacg cctctgcgtg tggaatggag aggcttctgg acatctgtgc     1080

tgccatgggg ctcctggaga agacagagca aggttacagt aacacagaga cagcgaacgt     1140

ctacctggca tcggatggcg aatactctct gcacggcttc atcatgcaca ataatgacct     1200

cacatggaac ctctttacat acctggagtt tgccatccga gagggaacaa accagcacca     1260

cagggcgttg gggaagaagg cggaagatct gttccaggat gcgtactacc agagcccgga     1320

gacgcggctg aggttcatgc gggccatgca cggcatgacg aagctgactg cgtgccaggt     1380

ggccacggcc ttcaatctgt cccgcttctc ctccgcctgc gacgtgggag gctgcacggg     1440

tgcactggcc cgagagctgg cccgtgagta ccctcgtatg caggtgactg tgtttgacct     1500

cccagacatt atcgagctgg ccgcccactt ccaacccccc ggaccgcagg cagtgcagat     1560

ccacttcgca gcaggtgact ttttcaggga ccccctcccc agcgctgagc tgtacgtcct     1620

gtgccggatc ctgcatgact ggccagacga caaagtccac aagttactca gcagggtcgc     1680

cgagagctgc aagccagggg ccggcctgct gctggtggag acgctcctgg atgaggagaa     1740

gagggtggcg cagcgcgccc tgatgcagtc actgaacatg ctggtgcaga ctgaaggcaa     1800

ggagcggagc ctgggcgagt atcagtgctt gctggagctg cacggcttcc accaggtgca     1860

ggtggtgcac ttggggggtg tcctggatgc catcttggcc accaaagtgg ccccctgaag     1920

cccaggcagc atgttcatta tagggatgtc ctcccccagg ctgcaggtgg accgcccggt     1980

ccccaagtac cataggacag tcacatagga gcgtgtagtc gtgactgaat aaagaaagca     2040

aaagcctg                                                              2048


<210> 4153
<211> 2034
<212> DNA
<213> Homo sapiens

<400> 4153
gcgcgtgcgg ggcagcaatg gagagctgag ggagcgtcgt cagggtggac accatgcgac       60

acccatttct cctttgcatc ctgtgtcttg gggttcaatg gggtgcacgt gatggggctt      120

ggggttaggc ccaggggagg gggtgggtgt ggcagccttg cgaagtggct gactttagga      180

ttcctagatc agaattttag accgctccat gtctgattcc tcaccgcaga accgacttag      240

tgcctttaca atccagtccc tcagccttgt gcttcccatc cgaccagcca tcggggacct      300

ctagcttcac atcctctttc cttgcagctc tggacatcct gagcccaagt cccccacact      360

cagtgcagtg atgagtgcgg aagtgaaggt gacagggcag aaccaggagc aatttctgct      420

cctagccaag tcggccaagg gggcagcgct ggccacactc atccatcagg tgctggaggc      480

ccctggtgtc tacgtgtttg gagaactgct ggacatgccc aatgttagag agctggctga      540

gagtgacttt gcctctacct tccggctgct cacagtgttt gcttatggga catacgctga      600

ctacttagct gaagcccgga atcttcctcc actaacagag gctcagaaga ataagcttcg      660

acacctctca gttgtcaccc tggctgctaa agtaaagtgt atcccatatg cagtgttgct      720

ggaggctctt gccctgcgta atgtgcggca gctggaagac cttgtgattg aggctgtgta      780

tgctgacgtg cttcgtggct ccctggacca gcgcaaccag cggctcgagg ttgactacag      840

catcgggcgg gacatccagc gccaggacct cagtgccatt gcccgaaccc tgcaggaatg      900

gtgtgtgggc tgtgaggtcg tgctgtcagg cattgaggag caggtgagcc gtgccaacca      960

acacaaggag cagcagctgg gcctgaagca gcagattgag agtgaggttg ccaaccttaa     1020

aaaaaccatt aaagttacga cggcagcagc agccgcagcc acatctcagg accctgagca     1080

acacctgact gagctgaggg aaccagctcc tggcaccaac cagcgccagc ccagcaagaa     1140

agcctcaaag ggcaaggggc tccgagggag cgccaagatt tggtccaagt cgaattgaaa     1200

ggactgtcgt ttcctccctg gggatgtggg gtcccagctg cctgcctgcc tcttaggagt     1260

cctcagagag ccttctgtgc ccctggccag ctgataatcc taggttcatg acccttcacc     1320

tcccctaacc ccaaacatag atcacacctt ctctagggag gaggcaaatg taggtcatgt     1380

ttttgttggt actttctgtt ttttgtgact tcatgtgttc cattgctccc cgctgccatg     1440

ctctctccct tgtttcctta agagctcagc atctgtccct gttcattaca tgtcattgag     1500

taggtgggta gccctgatgg gggtcgctct gtctggagca taacccacag gcgttttttc     1560

tgccacccca tccctgcatg cctgatcccc agttcctata ccctacccct gacctattga     1620

gcagcctctg aagagccata gggcccccac ctttactcac accctgagaa ttctgggagc     1680

cagtctgcca tgccaggagt cactggacat gttcatccta gaatcctgtc acactacagt     1740

catttctttt cctctctctg gcccttgggt cctgggaatg ctgctgcttc aaccccagag     1800

cctaagaatg gcagccgttt cttaacatgt tgagagatga ttctttcttg gccctggcca     1860

tctcgggaag cttgatggca atcctggaag ggtttaatct ccttttgtga gtttggtggg     1920

gaagggaagg gtatatagat tgtattaaaa aaaaaaaggt atatatgcat atatctatat     1980

ataatatgac gcagaaataa atctatgaga aatctatcta caaactaccc tgaa           2034


<210> 4154
<211> 1536
<212> DNA
<213> Homo sapiens

<400> 4154
gtcgcctccg ggctttctcc ggtcgctgcc gccaccaccg ttgcttcgcg ggctgggagg       60

cccggggtcc ccgggcgaac agaggctgcg gcactctcga gtggaccctg aggagctctt      120

caccaagctc gaccgcattg gcaagggctc gtttggggag gtctacaagg gcatcgataa      180

ccacacaaag gaggtggtgg ccatcaagat catcgacctg gaggaggccg aggatgagat      240

cgaggacatc cagcaggaga tcactgtcct cagtcagtgc gacagcccct acatcacccg      300

ctactttggc tcctacctaa agagcaccaa gctatggatc atcatggagt acctgggcgg      360

cggctcagca ctggacttgc ttaaaccagg tcccctggag gagacataca ttgccacgat      420

cctgcgggag attctgaagg gcctggatta tctgcactcc gaacgcaaga tccaccgaga      480

catcaaagct gccaacgtgc tactctcgga gcagggtgac gtgaagctgg cggactttgg      540

ggtagcaggg cagctcacag acacgcagat taagaggaac acattcgtgg gcaccccctt      600

ctggatggca cctgaggtca tcaagcagtc ggcctacgac ttcaaggctg acatctggtc      660

cctggggatc acagccatcg agctggccaa gggggagcct ccaaactctg acctccaccc      720

catgcgcgtc ctgttcctga ttcccaagaa cagcccaccc acactggagg gccagcacag      780

caagcccttc aaggagttcg tggaggcctg cctcaacaaa gacccccgat tccggcccac      840

ggccaaggag ctcctgaagc acaagttcat cacacgctac accaagaaga cctccttcct      900

cacggagctc atcgaccgct ataagcgctg gaagtcagag gggcatggcg aggagtccag      960

ctctgaggac tctgacattg atggcgaggc ggaggacggg gagcagggcc ccatctggac     1020

gttcccccct accatccggc cgagtccaca cagcaagctt cacaagggga cggccctgca     1080

cagttcacag aagcctgcgg agcccgtcaa gaggcagccg aggtcccagt gcctgtccac     1140

gctggtccgg cccgtcttcg gagagctcaa agagaagcac aagcagagcg gcgggagcgt     1200

gggtgcgctg gaggagctgg agaacgcctt cagcctggcc gaggagtcct gccccggcat     1260

ctcagacaag ctgatggtgc acctggtgga gcgagtgcag aggttttcac acaacagaaa     1320

ccacctgaca tccacccgct gaagcgcact gctgttcaga taggggacgg aaggtcgttt     1380

gtttttgttc tgagctccat aagaactgtg ctgacttgga aggtgccctg tgctatgtcg     1440

tgcctgcagg gacacgtcgg atcccgtggg cctcacatgc caggtcacca ggtcaccgtc     1500

tccttccacc cctgcagtgt gctgttgtgc acgtca                               1536


<210> 4155
<211> 556
<212> DNA
<213> Homo sapiens

<400> 4155
ctgcacgacg cctgtgtgtc tggcctttcc ttcttcttct cttccccggc agcacagtgt       60

ggctgtttgt ctccttgccc gccaaagttc tgcccagtcc aacgactcca cgcagctcgc      120

ccttggtaag gggtcgggga ggggcacaag ctcttcttta ctagaggttg gagtgcaatg      180

gcattatctt ggctcactgt aacctcaaac ttctgggctg aagcgatcct cctccctcag      240

cctcctgagt agctaggact acaggtgtga aaaagacagc atgaacttta ccccaacaca      300

cacccctgtc tgcagaaagc gaacagttgt ctccaaacgt ggtgttgccg tcagtggtcc      360

caccaagagg aggggaatgg cagattcact ggagtcaacc cccttgcctt cccccgaaga      420

tcgtctggcc aaactccatc cttctaagga gctcctggaa tattatcaaa agaagatggc      480

tgagtgtgag gcagaaaatg aggacttgct gaagaaactg gaactctaca aagaagcttg      540

tgaaggacag cataaa                                                      556


<210> 4156
<211> 899
<212> DNA
<213> Homo sapiens

<400> 4156
atggcccaga aggagaactc ctacccctgg ccctacggcc gacagacggc tccatctggc       60

ctgagcaccc tgccccagcg agtcctccgg aaagagcctg tcaccccatc tgcacttgtc      120

ctcatgagcc gctccaatgt ccagcccaca gctgcccctg gccagaaggt gatggagaat      180

agcagtggga cacccgacat cttaaccagg cggcacttca caattgatga ctttgagatt      240

gggcgtcctc tgggcaaagg caagtttgga aacgtgtact tggctcggga gaagaaaagc      300

catttcatcg tggcgctcaa ggtcctcttc aagtcccaga tagagaagga gggcgtggag      360

catcagctgc gcagagagat cgaaatccag gcccacctgc aatcatggag gagttggcag      420

atgctctaat gtactgccat gggaagaagg tgattcacag agacataaag ccagaaaatc      480

tgctcttagg gctcaaggga gagctgaaga ttgctgactt cggctggtct gtgcatgcgc      540

cctccctgag gaggaagaca atgtgtggca ccctggacta cctgccccca gagatgattg      600

aggggcgcat gcacaatgag aaggtggatc tgtggtgcat tggagtgctt tgctatgagc      660

tgctggtggg gaacccaccc tttgagagtg catcacacaa cgagacctat cgccgcatcg      720

tcaaggtgga cctaaagttc cccgcttccg tgcccatggg agcccaggac ctcatctcca      780

aactgctcag gcataacccc tcggaacggc tgcccctggc ccaggtctca gcccaccctt      840

gggtccgggc caactctcgg agggtgctgc ctccctctgc ccttcaatct gtcgcctga       899


<210> 4157
<211> 934
<212> DNA
<213> Homo sapiens

<400> 4157
acaacaagat ggcggcgctg cgggacggct agcggccctg cgtgcggttc ctcagtgact       60

atggcctgca gtgggtgggc gagcccatgg accaggagga ctcagagagc aagacagtct      120

cagagcatgg cgagagggac tggatgacag ccaagaagtt ctggaagcca ggggactcat      180

tggcgccccc tgaggtggac tttgacaggc tgctggccag cctgcaggat cttagtgagc      240

tggtggtaga gggtgacacc caagtgacac cagtgcccgg cggggcacgg ctgcgtaccc      300

tcgagcccat cccgctgaag ctctaccgga atggcatcat gatgttcgac gggcccttcc      360

agcccttcta cgatccctcc acacagcgct gcctccgaga catattggat ggcttctttc      420

cctcagagct ccagcgactg taccccaatg gggtcccctt taaggtgata agctgctcct      480

caaaccacac ctttggggat tttgaaggga gtggggatac acagcctccc cagacacctc      540

ccattctgag gggaagccgc tgcactccct gggggacccc agtctgatgc cctccaggag      600

gataagtctg aagccgggct gggaagggag cggagaggcc cgaaacagag cagcaggcag      660

cgccctctgc tggcaccctg gagacagcct cggctgcggg gcccctgcct tctagtcctc      720

cccagctttc aggacacctt gacaacctgg ggtccctgca gaagtggccc ggctgtcccc      780

caagtctcct gaagctatct gggtagggtg ggaggcagtg ctgtgagcca caaatgcaaa      840

gcagagggga cagatgttgg gactcaaaga catgaggtag agctggcccc atgggtaggt      900

gccaccacca gagcccatga ggcttcgtgt tcta                                  934


<210> 4158
<211> 2175
<212> DNA
<213> Homo sapiens

<400> 4158
cggacctctc aggctaatcc cgagggccgg gcctgttggg cttttctgca caccagccga       60

ggcagcgagc caacatgagc caagtgctgt tccaccaact agtcccgttg caggtgaaat      120

gcaaagactg tgaggagagg agagtaagta taagaatgag cattgaacta caatcagttt      180

ctaatccagt tcacagaaag tttaaaattc cagcaaggtc ttctggtaga cttcttagct      240

ttcccacaaa aatttataga tctccttcag caatgtactc aagaacatgc caaagaaatt      300

ccaaggtttt tgctacagtt agtttctcca gcagctattt tggataactc acctgcattt      360

ttaaatgtgg tagagacaaa tccttttaag catcttacac acctctcact aaaactttta      420

cctggaaatg atgtggagat aaagaaattt ctcgcaggct gtttgaaatg tagcaaggaa      480

gaaaaattat cattgatgca atcactagat gatgctacta agcaactgga ctttacacga      540

aagacattag cagaaaaaaa acaagaatta gataagttac ggaatgaatg ggcgtcacat      600

acagcagcct tgacaaacaa gcattctcag gaactgacaa atgaaaagga aaaagccttg      660

caggcacagg ttcaatatca acagcagcat gaacaacaga aaaaagattt agaaatcctc      720

catcaacaaa acatccacca gctacaaaac agactgtctg agttagaagc ggctaataaa      780

gacttaaccg aaagaaaata taaaggagac tccactatta gagaacttaa agcaaaactt      840

tctggtgttg aagaggagct acagcggact aagcaagaag tcctctcttt gcgaagagag      900

aattctacac tagatgttga atgccacgag aaagaaaagc acgttaatca gctacaaaca      960

aaagtggcag ttttagaaca ggaaatcaag gataaggacc agcttgtttt aagaacaaaa     1020

gaggcatttg atacaatcca ggaacaaaag gtggttttag aagaaaatgg tgagaaaaat     1080

caagtacaac taggaaagct tgaagctaca ataaaatcat tatctgcaga acttctgaag     1140

gcaaatgaaa ttatcaagaa gttacaaggg gatctgaaaa ctttaatggg taagttgaaa     1200

ttgaagaata cagttactat tcagcaagaa aaactcttgg ctgagaagga ggaaaaatta     1260

caaaaggaac aaaaggaatt acaagatgtt ggacagtctc ttcgaattaa agagcaagag     1320

gtatgcaaat tacaagaaca attagaagct acagttaaaa aacttgaaga aagcaaacaa     1380

cttctaaaaa ataatgaaaa gttaatcacg tggttaaata aagaactaaa tgaaaatcag     1440

ctagtgagaa agcaagatgt attgggacct tctactactc cgcctgcaca ttccagcagc     1500

aacacaatca gaagtggaat ttctcctaac ctgaatgtgg ttgatggtag actgacttac     1560

ccaacctgtg ggattggtta tcctgtctcc tctgcatttg cattccagaa taccttccct     1620

cattcgatat ctgccaaaaa taccagccac cctggttcag gaacaaaggt tcagtttaat     1680

ttgcagttta caaaaccaaa tgcatcacta ggagatgttc agtcaggagc aactattagt     1740

atgccttgct caactgataa ggaaaatggt gaaaatgtag ggttggaatc caaatacctg     1800

aagaaaaggg aagatagcat tcctttacgc ggactcagcc agaacctatt tagtaattca     1860

gaccatcaga gagatggcac tttaggagca ttacatacat cttccaaacc cacagcgctc     1920

ccctctgcgt cttcagccta tttccctggg cagttaccaa acagttaatt ctagtgtcat     1980

gttttacttt ttattggtat tttagaaact caggtgctta aaaaatatgt caacacaaac     2040

cagatcctca aatagcaagt ttcaaatttt acttgagctg ttaaagactg gatactttaa     2100

gtactgcttt tatggcagtt tataatatag gaacaaattt gtacttgggg attggtaaag     2160

attgtgagta aatga                                                      2175


<210> 4159
<211> 3681
<212> DNA
<213> Homo sapiens

<400> 4159
attggtgagt ggggcagggc aggagggaac tgaagagtga gaaagcatta tttcagcaaa       60

aggtctttcc tcccttgctc tctcctccaa ccactggctc agcctctccg cccgctgcct      120

gtgaatgatg caatggaagg tgtgctgggg tcgccctgtg tcccgtgcat aggagcatct      180

cagcctccag gtcctctcct ttggggctca cggcaccccc atgctacgaa ccgcaggcag      240

ggacggcctc tgtcgcctgt ccacctactt ggaagaactc gaggctgtgg aactgaagaa      300

gttcaagtta tacctgggga ccgcgacaga gctgggagaa ggcaagatcc cctggggaag      360

catggagaag gccggtcccc tggaaatggc ccagctgctc atcacccact tcgggccaga      420

ggaggcctgg aggttggctc tcagcacctt tgagcggata aacaggaagg acctgtggga      480

gagaggacag agagaggacc tggtgaggga taccccacct ggtggcccgt cctcacttgg      540

gaaccagtca acatgccttc tggaagtctc tcttgtcact ccaagaaaag atccccagga      600

aacctacagg gactatgtcc gcaggaaatt ccggctcatg gaagaccgca atgcgcgcct      660

aggggaatgt gtcaacctca gccaccggta cacccggctc ctgctggtga aggagcactc      720

aaaccccatg caggtccagc agcagcttct ggacacaggc cggggacacg cgaggaccgt      780

gggacaccag gctagcccca tcaagataga gaccctcttt gagccagacg aggagcgccc      840

cgagccaccg cgcaccgtgg tcatgcaagg cgcggcaggg ataggcaagt ccatgctggc      900

acacaaggtg atgctggact gggcggacgg gaagctcttc caaggcagat ttgattatct      960

cttctacatc aactgcaggg agatgaacca gagtgccacg gaatgcagca tgcaagacct     1020

catcttcagc tgctggcctg agcccagcgc gcctctccag gagctcatcc gagttcccga     1080

gcgcctcctt ttcatcatcg acggcttcga tgagctcaag ccttctttcc acgatcctca     1140

gggaccctgg tgcctctgct gggaggagaa acggcccacg gagctgcttc ttaacagctt     1200

aattcggaag aagctgctcc ctgagctatc tttgctcatc accacacggc ccacggcttt     1260

ggagaagctc caccgtctgc tggagcaccc caggcatgtg gagatcctgg gcttctctga     1320

ggcagaaagg aaggaatact tctacaagta tttccacaat gcagagcagg cgggccaagt     1380

cttcaattac gtgagggaca acgagcctct cttcaccatg tgcttcgtcc ccctggtgtg     1440

ctgggtggtg tgtacctgcc tccagcagca gctggagggt ggggggctgt tgagacagac     1500

gtccaggacc accactgcag tgtacatgct ctacctgctg agtctgatgc aacccaagcc     1560

gggggccccg cgcctccagc ccccacccaa ccagagaggg ttgtgctcct tggcggcaga     1620

tgggctctgg aatcagaaaa tcctatttga ggagcaggac ctccggaagc acggcctaga     1680

cggggaagac gtctctgcct tcctcaacat gaacatcttc cagaaggaca tcaactgtga     1740

gaggtactac agcttcatcc acttgagttt ccaggaattc tttgcagcta tgtactatat     1800

cctggacgag ggggagggcg gggcaggccc agaccaggac gtgaccaggc tgttgaccga     1860

gtacgcgttt tctgaaagga gcttcctggc actcaccagc cgcttcctgt ttggactcct     1920

gaacgaggag accaggagcc acctggagaa gagtctctgc tggaaggtct cgccgcacat     1980

caagatggac ctgttgcagt ggatccaaag caaagctcag agcgacggct ccaccctgca     2040

gcagggctcc ttggagttct tcagctgctt gtacgagatc caggaggagg agtttatcca     2100

gcaggccctg agccacttcc aggtgatcgt ggtcagcaac attgcctcca agatggagca     2160

catggtctcc tcgttctgtc tgaagcgctg caggagcgcc caggtgctgc acttgtatgg     2220

cgccacctac agcgcggacg gggaagaccg cgcgaggtgc tccgcaggag cgcacacgct     2280

gttggtgcag ctaccagaga ggaccgttct gctggacgcc tacagtgaac atctggcagc     2340

ggccctgtgc accaatccaa acctgataga gctgtctctg taccgaaatg ccctgggcag     2400

ccggggggtg aagctgctct gtcaaggact cagacacccc aactgcaaac ttcagaacct     2460

gaggctgaag aggtgccgca tctccagctc agcctgcgag gacctctctg cagctctcat     2520

agccaataag aatttgacaa ggatggatct cagtggcaac ggcgttggat tcccaggcat     2580

gatgctgctt tgcgagggcc tgcggcatcc ccagtgcagg ctgcagatga ttcagttgag     2640

gaagtgtcag ctggagtccg gggcttgtca ggagatggct tctgtgctcg gcaccaaccc     2700

acatctggtt gagttggacc tgacaggaaa tgcactggag gatttgggcc tgaggttact     2760

atgccaggga ctgaggcacc cagtctgcag actacggact ttgtggctga agatctgccg     2820

cctcactgct gctgcctgtg acgagctggc ctcaactctc agtgtgaacc agagcctgag     2880

agagctggac ctgagcctga atgagctggg ggacctcggg gtgctgctgc tgtgtgaggg     2940

cctcaggcat cccacgtgca agctccagac cctgcggttg ggcatctgcc ggctgggctc     3000

tgccgcctgt gagggtcttt ctgtggtgct ccaggccaac cacaacctcc gggagctgga     3060

cttgagtttc aacgacctgg gagactgggg cctgtggttg ctggctgagg ggctgcaaca     3120

tcccgcctgc agactccaga aactgtggtt atttgggatg gacctgaata aaatgaccca     3180

cagtaggttg gcagcgcttc gagtaacaaa accttatttg gacattggct gctgaatggt     3240

cctatctgct ggctctcccc tgagatctgg acagaggaag atgggagggt gctcatcacc     3300

cccccagcat aatgatcagc ctccttccta gagacagact catgcagatt gagatcaaaa     3360

gtccctctgc ttgggatcaa attaatgttt gacagagctg gccaggcgtg gtggctcatg     3420

tatgtaatcc tagcacttcg agaggccgag gcaggtggat cacgaggtca ggagtttgag     3480

attagcctgg ccaagatggt gaaaccctgt ctctactaaa aataaaaaaa aattagccag     3540

gcatggtggc gggcacctgt agtcccagct actcaggagg ctgaggcagg agaatcgctt     3600

gaacccggga ggtggaggtt gcagtgagcc gagatcgcgc cactgcactc cagcctgggc     3660

gacagagtgg gactccatct c                                               3681


<210> 4160
<211> 4641
<212> DNA
<213> Homo sapiens

<400> 4160
aagcactttc gcgccgtatc cctccgcccc ccttcccgac accctcgcgg cgagcggttc       60

ttgccgcatc ctgcgcagcc cctgcctact ttggtgcaga ggcgtggggg gcgggacgcg      120

tctttcccgt tcggatcgcg gggaaagcag tggctccaag tgagccagag gagagctgag      180

gagaggaggg ggaggccgac gacctgggcc ctgggcctct gaaggcctac tttaaggctg      240

gccaattctg caagaaaggc aaggaggagg agactggctc acagctctgg aggaccccct      300

tctgtcagct gtggggcttg acaccacttg aacaagaaaa ggagggggaa actgcaccac      360

atcagtgaag gaggcagccg gtccagagag actttctcaa agcccagctg tcccacctag      420

cattcaacat cagtcgcact gcatacgtct catacaattg gaagagactc aaagcctcat      480

ttcattctct ctccctagat ccacctccag tggctgctct gctggtggtg gagttgctgc      540

tgacaaccac cctcaacggg tctgcaccca tccaggaaat atctgtcttc ctttagcttg      600

gttgtacctg ttctcactct atctgtatta ttgaattatt gactgagact gtgtttggga      660

aggaggctga gtgactactg gactggatat tgactctaac tcttattccc aagcttatat      720

ccttaatcac ctaaagatca gagtgtgaag aaacaaacct gtgacagatc tgtggttgag      780

gtttagacta cgggaggagt atattacctg actttctttg taacttgtac catgactggg      840

gcagagattg agcctagtgc ccaggccaag cctgaaaaga aggctgggga agaggttatc      900

gctgggcctg agagagagaa tgatgtccct ctggtggtca gacccaaggt taggacccag      960

gcaactactg gggcaaggcc caaaactgag accaagtctg tgcctgcggc aaggcccaaa     1020

actgaggccc aagcaatgtc tggggcaagg cccaaaactg aggtccaagt aatgggtggt     1080

gcaagaccca aaacggaggc tcaaggaatc acaggggcca ggcccaaaac cgatgccagg     1140

gcagtaggtg gcgctcgttc taaaactgat gccaaggcaa tccctggagc aaggcccaag     1200

gatgaggccc aggcatgggc ccagagtgaa tttgggactg aagcagtgtc acaggcagaa     1260

ggagtgtccc agactaatgc cgttgcttgg ccactggcca ctgctgagtc tggatcagtt     1320

actaaatcta agggcctgtc tatggataga gaactagtca atgtggatgc tgaaaccttt     1380

cctggcaccc agggtcagaa aggaatccag ccctggtttg gaccagggga ggagactaat     1440

atggggtctt ggtgctattc caggcccagg gccagagagg aggcctctaa tgagtctggg     1500

ttctggtcag cagatgagac ctctacagcg tcttctttct ggactggaga agagacaagt     1560

gtcagatcat ggcccaggga agagtccaat accaggtcca ggcacagggc taaacatcag     1620

actaatccca ggtccaggcc cagatccaag caagaagcct atgttgattc ctggtctgga     1680

tctgaggatg aggccagcaa cccattctcc ttctgggttg gagaaaatac caataacttg     1740

ttcaggccca gagtcaggga ggaggcaaat atcaggtcca agctcaggac aaatagagaa     1800

gattgttttg aatctgagtc tgaagatgag ttctataagc agtcctgggt tttgcctgga     1860

gaagaggcca atagtagatt caggcacaga gacaaagaag atcctaatac tgccttgaaa     1920

ctcagggccc agaaagatgt tgacagtgat agggtcaaac aagaacccag gtttgaggag     1980

gaagtcatta ttgggtcctg gttctgggca gaaaaagagg ccagtttgga gggtggagct     2040

tcagcaatct gtgaatctga gccaggaact gaggaggggg ccattggcgg atccgcgtac     2100

tgggctgagg aaaagtccag tttgggggct gtggccagag aagaggccaa gccggagtct     2160

gaagaagagg ccatatttgg gtcctggttc tgggacagag atgaggcctg ctttgaccta     2220

aatccctgtc ctgtgtacaa ggtcagtgat aggttcagag atgcagctga ggagcttaat     2280

gcatcctcca ggccccaaac ctgggacgag gtcactgttg aattcaaacc tggtcttttt     2340

catggggttg gcttccgatc cacaagcccc tttggaattc ccgaagaggc ttctgaaatg     2400

cttgaggcaa agcccaagaa cctggaactt agcccagaag gagaagagca ggaatctttg     2460

cttcagcctg atcagcctag tcctgagttc acatttcagt atgatccttc ctaccggtca     2520

gtccgggaaa ttcgagagca tcttagggcc agggagagtg cagagtctga gagttggtcc     2580

tgcagctgca tacaatgtga gctgaaaatt ggttctgaag agtttgaaga attcctttta     2640

ttaatggaca aaattcggga tccttttatt catgaaatat ctaaaattgc aatgggtatg     2700

agaagtgctt ctcaatttac ccgagatttc attcgagatt caggtgttgt ctcacttatt     2760

gaaaccttgc ttaattatcc atcctctaga gttaggacaa gttttttgga aaatatgatt     2820

cacatggctc caccttatcc aaatctaaac atgattgaga cattcatatg tcaagtgtgt     2880

gaggaaaccc ttgcacatag tgtggattcc cttgagcagc tgactggaat aaggatgctt     2940

agacacctca ctatgactat tgactatcac acactgattg ccaactatat gtccgggttt     3000

ctctccttat taaccacagc caatgcgaga acgaagtttc acgttctgaa aatgctattg     3060

aatttgtctg aaaatcctgc tgtggcaaaa aaactattca gtgccaaagc tctttcaata     3120

tttgtgggtc tctttaacat agaagagaca aatgataata ttcaaattgt tattaaaatg     3180

tttcagaata tcagtaacat tataaaaagt ggaaagatgt ccttaattga tgatgatttc     3240

agtcttgagc cgcttatttc tgcatttcgt gaatttgagg agttagctaa gcaactacaa     3300

gcccaaatag acaaccaaaa tgatcctgag gtgggacaac aaagttaata tgattaacca     3360

cctgccgctg atcagcctta tgttcccaaa gagccctgag tagtgctttg gtgttcacag     3420

tctgtttttt tgttgtaact tatatttttt aatgctgatg ttaactttgt caaactcttg     3480

ttttgagctg gatcattttg tggatgccaa atgaatatca aaactgaaaa cacatttgtt     3540

gatatttgtc ttgctgtcca gattgcggta tttttcagta ttaagttttc aatgaactgt     3600

gtcacctaag taagctaccc tgctattcgt tgtttaaata tatggttctc tatttgagtc     3660

tgtgttttca ataaagttct atgttaaaat tggcataagt gacccttctt cagtttaaga     3720

accatgtaca gataaatcgt gtgcacttac aaacataggt aattattagt atgacaaaca     3780

tgcgcttatt agaaaattct gttcttgagt taagaaggga gagattattg tgggccctga     3840

tacttgagga atgtttccga gaagagggac ccacttaaat tggtcaggat agaacaaatt     3900

ggtcaggata ggagagcaag acaacttgcc cgcctgcttg cccaattatg agccttccca     3960

acaagcaacc taaaattaat acttcttata ggacccattt aaattaccat cttagccctg     4020

ggatttgcct aagggtagga taagacaaat cattaggttg ctcttggaag tgggcagtgg     4080

tggtttgaag aaaagtgtgt aattgaataa tctgttctag tagcatggat gaacccagtc     4140

tgcttgaaac aagtaaaagg agtttgatga gaaatgcagt tagaaagttg ggaagaggcc     4200

aatttgggga acagaataag ccaaatctgc atatttaaca attcaaagta caggtgttac     4260

ttcaatgcca cctaaaggct gaaagagtag gatagcacaa ttaaatggag tggggaatat     4320

gatttccttt atattcctag acaaaggaaa gtgttaagga aataccatgc agccgttgga     4380

atgattatgt atggataggt ttattgacac aaaaggacat taattatttt atatttggtg     4440

aaacagagaa tgtgacatca tgtatggaaa attagattcc atttttaaaa catctgtaaa     4500

tgtacacaat tcctatgcaa tttcaatatg aatttctaaa cacagtctgg aataaaatat     4560

ataccttgtt aaaaaatgct tagagacagg cgttggggag atacaaacat taataagaca     4620

aattaaaaaa ttaatatgct t                                               4641


<210> 4161
<211> 550
<212> DNA
<213> Homo sapiens

<400> 4161
agaaaaggct ggagtcccag tccgtggagg agcacttaca gggtctttcc taagtgctga       60

tggcaaagaa ttagaaacta agtggatgct ttcgacagag gaacagttgg ataagatgtc      120

acacgtccat gccttggatt tctgcacttg acctggaagg attcccatga gaaaagaaaa      180

gggctctgtg tatgaatgac aaggatacct tcagccagct cattctggat gaatgaatga      240

ttacactaag tgtcctccac attcctctgt gggctcactt catggactca ctttgcgtgc      300

ttgttaaatg tgctgtgttg ctcccaagac catgtaaagc ctactgacca ctaacctccc      360

tcacagcaga aactagacgt caggttaaaa tgggcaactc cgacagtcag tacacccttc      420

aaggatctaa aaatcatagc aatactatta ctggtgctaa gcaaattcct tgctccctga      480

aaatacgtgg cattcatgca aaagaggaaa agtcattgca tggatggggt cacggaagca      540

acggagcagg                                                             550


<210> 4162
<211> 1398
<212> DNA
<213> Homo sapiens

<400> 4162
cctggagttc cggccaggcc actgcttggg aagcaagaag gtgaaggcac ctctgctggg       60

ccaagcactc ttagggccga ggggcactgc agctgacaag agctccctgt ttcgctgagg      120

cctggagccc ccatggcctc actgagccga gccctacgtg tggctgctgc ccaccctcgc      180

cagagcccta cccggggcat ggggccatgc aacctgtcca gcgcagctgg ccccacagcc      240

gagaagagtg tgccatatca gcggaccctg aaggagggac agggcacctc ggtggtggcc      300

caaggcccaa gccggcccct gcccagcacg gccaacgtgg tggtcattgg tggaggcagc      360

ttgggctgcc agaccctgta ccacctggcc aagctgggca tgagtggggc ggtgctgctg      420

gagcgggagc ggctgacctc cgggaccacc tggcacacgg caggcctgct gtggcagctg      480

cggcccagtg acgtggaggt ggagcttctg gcccacactc ggcgggtggt gagccgggag      540

ctggaggagg agacgggact acacacgggc tggatccaga atgggggcct cttcatcgcg      600

tccaaccggc agcgcctgga cgagtacaag aggctcatgt cgctgggcaa ggcgtatggt      660

gtggaatccc atgtgctgag cccggcagag accaagactc tgtacccgct gatgaatgtg      720

gacgacctct acgggaccct gtatgtgccg cacgacggta ccatggaccc cgctggcacc      780

tgtaccaccc tcgccagggc agcttctgcc cgaggagcac aggtcattga gaactgccca      840

gtgaccggca ttcgtgtgtg gacggatgat tttggggtgc ggcgggtcgc gggtgtggag      900

actcagcatg gttccatcca gacaccctgc gtggtcaact gtgcaggagt gtgggcaagt      960

gctgtgggcc ggatggctgg agtcaaggtc ccgctggtgg ccatgcacca tgcctatgtc     1020

gtcaccgagc gcatcgaggg gattcagaac atgcccaatg tccgtgatca tgatgcctct     1080

gtctacctcc gcctccaagg ggatgccttg tctgtgggtg gctatgaggc caaccccatc     1140

ttttgggagg aggtgtcaga caagtttgcc ttcggcctct ttgacctgga ctgggaggtg     1200

ttcacccagc acattgaagg cgccatcaac agggtccccg tgctggagaa gacaggaatc     1260

aagtccacgg tctgcggccc tgaatccttc acgcccgacc acaagcccct gatgggggag     1320

gcacctgagc tccgagggtt cttcctgggc tgtggcttca acagcgcagg tgagtccggg     1380

caggccctcc tggccccc                                                   1398


<210> 4163
<211> 665
<212> DNA
<213> Homo sapiens

<400> 4163
attaagctgt gaatgaacct cccaaaccca ggaatatgat atgagaacat agcctttgaa       60

tttctctctc aagtttgact tgaaaaatca gcctcagaaa catctttatc ttaagataga      120

tttccgttgc tctcagaacg tctctcccct gaccttctgt tattaagttc atggacatac      180

agcattttag aattaggtgg gggctccgaa gtctgcgagt gcagctgtgc acagatttaa      240

tccagagact gacttcacta tagaacccac agttgtatca atggttgggg aaagatagtg      300

gcaacaggca aaggagaaac agctctgaca tacaaagaaa atgagtatgc taaagccaag      360

tgggcttaag gcccccacca agatcctgaa gcctggaagc acagctctga agacacctac      420

ggctgttgta gctccagtag aaaaaaccat atccagtgaa aaagcatcaa gcactccatc      480

atctgagact caggaggaat ttgtggatga ctttcgagtt ggggagcgag tttgggtgaa      540

tggaaataag cctggattta tccagtttct tggagaaacc cagtttgcac caggccagtg      600

ggctggaatt gttttagatg aacccatagg caagaacgat ggttcggtgg caggagttcg      660

gtatt                                                                  665


<210> 4164
<211> 2775
<212> DNA
<213> Homo sapiens

<400> 4164
ctgcaggacg agccgagagg ctcagccata tttgatggtt ttgttgcttt gctcgggagt       60

tctcgggagt aatttaatgc cgaaggtcgc tgcctagtgg aaataatata atacgtcatt      120

aatatggcgc caaaagattg ggttctcgat ctgtagcgag gagggaggga ggcagccgct      180

gagcgcagcg ttactatccc accagtaact tgggcattgc cggggcgggg gccggaggag      240

gaggagagga tgatttttgg atcctgagaa ttgatctatg ttggatcagc tgcctgctgt      300

ttcccgggga gatcatgaaa cgaggtcgcc ttcccagcag cagtgaggat tctgacgaca      360

atggcagcct gtcaactact tggtcccaga attcccgatc ccagcatagg agaagctcct      420

gctccagaca tgaagatcga aagccttcag aggtgtttag gacagacctg atcactgcca      480

tgaagttgca tgactcctac cagctgaatc cggatgagta ctatgtgttg gcagatccct      540

ggagacagga atgggagaaa ggggtccagg tgcctgtgag cccggggacc atccctcagc      600

ctgtggccag ggttgtgtct gaagagaaat ccctcatgtt catcaggccc aagaagtaca      660

tcgtgtcatc aggctctgag cctcccgagt tgggctatgt ggacatccgg acgctggctg      720

acagcgtgtg tcgctatgac ctcaatgaca tggatgctgc atggctggaa ctgaccaatg      780

aagaatttaa ggagatggga atgcctgaac tagatgaata caccatggag agggtcctag      840

aggaatttga gcagcgatgc tacgacaata tgaatcatgc catagagact gaggaaggcc      900

tggggatcga atatgatgaa gatgttgtct gtgatgtctg ccagtctcct gatggtgagg      960

acggcaatga gatggtgttc tgtgacaaat gcaacatctg tgtgcaccag gcctgttatg     1020

gaatcctcaa ggtaccagag ggcagctggc tgtgccggac atgtgccctg ggggttcagc     1080

caaaatgtct gctgtgtccg aagaagggtg gagctatgaa gcccacccgt agcggaacca     1140

agtgggtcca cgttagctgt gctctgtgga tccctgaggt gagcattggc agcccagaga     1200

agatggagcc catcaccaag gtgtcacaca ttcccagcag ccggtgggcg ctagtgtgca     1260

gcctctgcaa tgagaagttt ggggcctcta tacagtgctc tgtgaagaac tgccgcacag     1320

ccttccatgt gacctgtgct tttgaccggg gcctggagat gaagaccatc ttagcagaga     1380

atgatgaagt caagttcaag tcctattgcc caaagcacag ctcacatagg aaacccgagg     1440

agagtcttgg caagggggct gcacaggaga atggggcccc tgagtgttcc ccccggaatc     1500

cgctggagcc ctttgccagc cttgagcaga accgggagga ggcccaccgg gtgagtgtcc     1560

gtaagcagaa gctgcagcag ttggaggatg agttctacac cttcgtcaac ctgctggatg     1620

ttgccagggc tctgcggctg cctgaggaag tagtggattt cctgtaccag tactggaagt     1680

tgaagaggaa ggtcaacttc aacaagcccc tgatcacccc aaagaaagat gaagaggaca     1740

atctagccaa gcgggagcag gatgtcttat ttaggaggct gcagctgttc acgcacctgc     1800

ggcaggacct ggagagggtt cggaacctca cttacatggt gacccgcagg gaaaagatta     1860

aacggtctgt gtgcaaagtc caggaacaga tattcaatct ttacactaag cttttggagc     1920

aagaaagagt ttcaggtgtg ccttcttcct gctcctcctc ctcactggaa aacatgcttt     1980

tgtttaacag tccttctgtt ggccctgatg ctcccaagat agaggacttg aagtggcatt     2040

ctgcattctt cagaaaacaa atgggtactt ccttggttca ttcgctgaaa aagccccata     2100

agcgagatcc tttgcagaat agccctggaa gtgaaggcaa aaccctgctg aagcagccag     2160

acctgtgtgg tagaagggag gggatggtgg tcccagagag ctttttgggt ttagaaaaga     2220

cctttgcaga agcacgtctc atatcagcac aacagaaaaa tggtgtggtg atgccagacc     2280

atgggaaaag aagagacaat cgttttcatt gtgatctcat taaaggagac ttaaaggaca     2340

aatcttttaa acagagtcac aagcctctca ggtccacaga tgtgtcccag aggcatctgg     2400

acaacacaag agctgctgca atatggagat ttagggtaat atggcaaggt cctgctgctt     2460

gaagcctgtg agtgggttgt ggatatggga ctggtggaga gtgagactgt taggaaagtt     2520

gtatctatga ataagggcag ttgaagtaga atttttacca gtccacttga ccttcttctt     2580

ccctaaccac tggctcttga gccagcttgg gatttccctg gccattgcca atacctggcc     2640

atctggcttc caatagtaca gtggctactc aagttcaagc gaagaacttc cagactctgg     2700

tgactgttac ttcccagagc caaccactag tgcatatgtt agggaatctg ggcttccaac     2760

atgaatggat tcctt                                                      2775


<210> 4165
<211> 494
<212> DNA
<213> Homo sapiens

<400> 4165
ggaggggcgc gaggtttcaa gatggcggta gctgaggggt tgaccgagag acccagttga       60

aggcctttac gaagtgaaag aggccgggag tcgcccccta cccgcttctc gtagtcctgg      120

gagcacagca gaagtttgtg ttttgaactc ttgagagtca agcattatat ctgaactaga      180

actgaatctg aattaaatat gcttaaatta atgagttttt agtgtcttag aagtattgag      240

aatgtacagc atacatgcca agaaaaacca tggagagagg caaaggtgag gtttttcttt      300

ttttaatgaa caagtaaacc atacaaattg tcaacatggg acggagatct acatcatcca      360

ccaagagtgg aaaatttatg aaccccacag accaagcccg aaaggaagcc cggaagagag      420

aattaaagaa gaacaaaaaa cagcgcatga tggttcgagc tgcagtttta aagatgaagg      480

atccaaaaca gata                                                        494


<210> 4166
<211> 1351
<212> DNA
<213> Homo sapiens

<400> 4166
ctgcttgttg gacatgaaga gagggagaca aaggctctca gaaagagaaa gacgggctgg       60

tgaaggacaa actaaggaat ttgattattc acttttccaa gataaagtgg catggagtgg      120

ggaaagacca ttaaggaatg ctgaacataa aggaatcctg gggacctgac cctcagttaa      180

gacataagaa tgacaaccag gagtgtgctc gatgttgaaa catttgtagc agatatactg      240

aaaggagaaa atttatccaa gaaagcaaag gaaaagagag aatcccttat taagaagata      300

aaagatgtaa agtctatcta tcttcaggaa tttcaagaca aaggtgatgc agaagatggg      360

gaagaatatg atgacccttt tgctgggcct ccagacacta tttcattagc ctcagaacga      420

tatgataaag acgatgaagc cccctctgat ggagcccagt ttcctccaat tgcagcacaa      480

gaccttcctt ttgttctaaa ggctggctac cttgaaaaac gcagaaaaga tcacagcttt      540

ctgggatttg aatggcagaa acggtggtgt gctctcagta aaacggtatt ctattattat      600

ggaagtgata aagacaaaca acagaaaggt gaatttgcaa tagatggcta cagtgtcaga      660

atgaataaca ctctaagaaa ggatggaaag aaagattgct gttttgaaat ctctgctcct      720

gataaacgta tatatcagtt tacagcagct tctcccaaag atgctgaaga atgggtacag      780

cagctgaaat ttgtattgca agatatggaa tctgatatta ttcctgagga ttatgatgag      840

agaggagaat tatatgatga tgttgatcat cctctaccaa taagcaatcc actaacaagc      900

agtcaaccaa tagatgatga aatttatgaa gaacttccag aagaagaaga ggacagtgct      960

ccagtgaaag tggaagaaca aaggaagatg agtcaggata gtgtccatca cacctcaggg     1020

gataagagca ctgattatgc taatttttac cagggattgt gggattgtac tggagctttt     1080

tctgatgagt tgtcatttaa gcgtggtgat gtgatttaca ttcttagcaa ggaatacaat     1140

agatatggct ggtgggtagg agaaatgaag ggagccattg gcttggtgcc taaagcctac     1200

ataatggaga tgtatgatat ttgagagtcc tggaaaagga aaattcttct gcttgtctgc     1260

aaatgctttg gatttagaag cgtcatgaaa gcacgagtga cagctcctaa cctctccttg     1320

ttttattaaa cattacttat ctttgactgt t                                    1351


<210> 4167
<211> 3389
<212> DNA
<213> Homo sapiens

<400> 4167
gaaaccgttt ggcaggggcg gcggtggcgg cggcgttggc ggcagcggcc gagcggaaag       60

cttgcgtgtg gtggtgccag attggattat ggaagtggga agtgaagaag aaaaatggga      120

gaagctggat gcagaatttg atcactttgt ggttgatatg aagccctttg ttctaaaatt      180

acctcatagg acagaacggc agaggtgtgc tctttggatt agaaagctgt gcgaaccttc      240

aggaacaggt gcaggaataa tggggaggaa gaatcggaac ctgtatgcaa aattgttatt      300

gcatatgctt aaacgaggtg cgcttgaagg cccttttaca caccgacctg aacccgggac      360

actaaaaatt ctaccttcat acatgtccat ctattttgat gaaccaaatc cagcacgagc      420

aaaaggttca agcccagagg gattaccagc ctgggtactg ggtgagctgg agacaagtga      480

acacaaatta aatgaatcat ggaaactctc ttctggagaa gataacactt tagtacagtc      540

gccaactgat gtctacagca gggaacagta cactgggaag ctccgagtga gatcacactc      600

cttgagtcca actcacagag aagatggaca aaatattacc ccaaagattt gtgaagttta      660

ttcgaaaaaa tctcctgttt ctttggatga tagtgacatt gaagctcgcc ttaatagttg      720

gaatcttggg atagaaaatc ctcgatacct gagacagaag cctatcccag tttctctgat      780

gacaccgaaa ttcagcctga gaaaatccag cagtttccat gatgatcatt ttctctctcg      840

aatacgtgag aaagagctgg acatgaaaac aaaaatgatg gaagctaaat ttcatgaaga      900

aaagcttaaa ctgcaacaga aacatgatgc tgatgttcag aagattttag aaagaaagaa      960

taatgaaata gaagaactga aaactttata caggagtaaa caacatgaaa ctgaagagac     1020

tattagaaag cttgaaaaga aagttcagac actgatacgt gactgtcaag ttatcagaga     1080

gactaaagaa gaccagattg cagagctgaa aaagatatgt gaacaaagta cggaatctct     1140

aaataatgac tgggaaaaaa agcttcacaa tgctgtagca gaaatggaac aggaaaagtt     1200

tgatcttcaa aagcaacaca ctgaaaacat tcaagaattg cttgaggata caaatgtgcg     1260

tctgaataaa atggagagtg aatacatggc gcaaacacag tccacaaacc acatgatcaa     1320

agaactggag gcccgtgtcc agcagctgac tggagaagca gagaacagta atttacagag     1380

gcagaaatta attcaagaaa aagcagaact tgaaagatgt taccagataa cgtgtagtga     1440

attacaagaa gtaaaggcaa ggcgtaacac actgcataaa gagaaggacc atcttgtaaa     1500

tgattatgag caaaacatga aactgttaca aaccaaatat gatgctgata taaaccttct     1560

aaaacaagaa catgctcttt cagcttctaa ggcatctagt atgattgaag aattagagca     1620

gaatgtctgt caattaaaac agcagttaca ggaatcagaa cttcaaagaa agcaacaact     1680

aagggatcaa gaaaataagt ttcagatgga gaaaagtcat ttaaaacaca tctatgaaaa     1740

aaaggctcat gacttgcaga gtgaacttga taaaggaaaa gaagatactc aaaagaaaat     1800

tcataaattt gaggaagctt tgaaggaaaa agaggagcag ctaactcgtg tgactgaagt     1860

tcagaggttg caggcccagc aggcagatgc cgctctggaa gagtttaagc ggcaggtgga     1920

actgaactca gagaaagtct atgctgaaat gaaagagcag atggaaaaag tggaggcaga     1980

tctaactaga tccaaatctc ttcgtgagaa acaatcaaag gagtttttat ggcaactgga     2040

ggacatcaga cagcggtatg aacaacagat agtagagctg aagctggagc atgaacagga     2100

gaagacgcac ctattacagc agcataacgc agagaaggat agcctagtcc gagaccatga     2160

acgggaaatt gaaaacctgg aaaaacagct tcgcgctgcc aatatggagc acgaaaatca     2220

aattcaggag ttcaagaaac gagatgcaca ggttattgcc gacatggagg cccaggttca     2280

caagttgaga gaagaattga tcaatgtgaa ctcacagcgg aaacagcagc tggtagagct     2340

tggtcttctt cgtgaagagg aaaagcaaag ggctacaagg gaacatgaga ttgtcgtcaa     2400

taaactgaag gctgaatcag aaaagatgaa aatagagctg aaaaagactc atgctgctga     2460

gacagagatg acactggaaa aggccaacag caagctgaag cagattgaga aggaatacac     2520

tcagaagctt gccaaatctt cacagatcat agcagaactt cagacaacca tttcctctct     2580

gaaagaagag aacagccagc agcagcttgc tgcagaaagg cggctccagg atgttagaca     2640

aaagtttgaa gatgagaaga agcagctgat tagagataat gaccaagcaa tcaaggtttt     2700

acaagatgaa ttagaaaacc gttctaatca ggtgcgatgt gcagagaaaa aattacaaca     2760

caaagaattg gagtcacagg aacagataac ttacatacga caagaatatg aaacaaaatt     2820

gaaaggattg atgccagcat ccctaagaca agaacttgaa gacaccattt cctccctaaa     2880

atcacaggtt aattttctgc aaaagagagc ttccatcctt caggaagaac tgactacata     2940

tcaaggcaga aggtaactgc acgagagaat gcaacggatg caatttccag gctgtgctgt     3000

ggacttcttc cagcaggttt gaagatttgg atattgtaaa ctgtgagatc agtggcattt     3060

tttaaatcct taaatgtaat taagatcata aaaacatgca tcattcatac actagtgggg     3120

tggttttatt tgtgtctgcc taagttattt ttttaacatt cctttatttc cgattttcat     3180

gtttgtgtgc atttgagtat gtgctgagaa ctgcttatat tgggcaaagt gatttcctat     3240

gatatgcctt gttaatcctt ttgcatagaa ttttaccagt tgcgtacgat caaaatcacg     3300

tttgtagtat catatcaaaa attctaacct gtttacattg ttttcatgtt catgttccta     3360

tgttattaaa atattatttt gtacttacc                                       3389


<210> 4168
<211> 1663
<212> DNA
<213> Homo sapiens

<400> 4168
gtttccccct tgggcggtgg tggaggtggt aaccgtgata gtagcagctc cggcggcagc       60

aacagcgact acgagggatg gcggcggctg cagcaggaac tgcaacatcc cagaggtttt      120

tccagagctt ctcggatgcc ctaatcgacg aggaccccca ggcggcgtta gaggagctga      180

ctaaggcttt ggaacagaaa ccagatgatg cacagtatta ttgtcaaaga gcttattgtc      240

acattcttct tgggaattac tgtgggaaaa actgaatacc ttgagtaaaa ttacatagaa      300

aatgttaatg agacaaggag gtgaattttg tgacacagct gtattcattg aagagcttta      360

agaaggaagc taaatgttaa gccaaaagga agttgctgtt gctgatgcaa agaagtctct      420

agaactcaat ccaaataatt ccactgctat gctgagaaaa ggaatatgtg aataccatga      480

aaaaaactat gctgctgccc tagaaacttt tacagaagga caaaaattag atagtgcaga      540

tgctaatttc agtgtctgga ttaaaaggtg tcaagaagct cagaatggct cagaatctga      600

ggtgtggact catcagtcaa aaatcaagta tgactggtat caaacagaat ctcaagtagt      660

cattacactt atgatcaaga atgttcagaa gaatgatgta aatgtggaat tttcagaaaa      720

agagttgtct gctttggtta aacttccttc tggagaggat tacaatttga aactggaact      780

tcttcatcct ataataccag aacagagcac gtttaaagta ctttcaacaa agattgaaat      840

taaactgaaa aagccagagg ctgtgagatg ggaaaagcta gaggggcaag gagatgtgcc      900

tacgccaaaa caattcgtag cagatgtaaa gaacctatat ccatcatcat ctccttatac      960

aagaaattgg gataaattgg ttggtgagat caaagaagaa gaaaagaatg aaaagttgga     1020

gggagatgca gctttaaaca gattatttca gcagatctat tcagatggtt ctgatgaagt     1080

gaaacgtgcc atgaacaaat cctttatgga gtcgggtggt acagttttga gtaccaactg     1140

gtctgatgta ggtaaaagga aagttgaaat caatcctcct gatgatatgg aatggaaaaa     1200

gtactaaata aattaatttg ctctcatcgt attgtgtata ttcacctaat gcccattgtg     1260

tattgatatt gcattcttga attttgaaca ctgaatatct ttttgaaaga ttatacttct     1320

ttacctcttt gtgctttaga aattattttc cttcaagtgt tcaagtctaa tgaagaatga     1380

agataacatt ttatcacttc tgtccttaaa ggtttcagac atggtgaaac tgaataaagc     1440

atgtcatttg ctcctagata gattcattct atctagttgt ggggatggag aaatctttaa     1500

tggtatattt tcggttattg ccttattttt gatacagtat tctgtcagta atttattaga     1560

cctggcagct ttgggtgagc ttagattttt caccttcagt gttacattgt gtttgctttt     1620

aaaaactgct tttgaatgga gttgtaaata caatttttct atg                       1663


<210> 4169
<211> 1327
<212> DNA
<213> Homo sapiens

<400> 4169
cgagctgttg tgcatccaga ggtggaattg gggcccggta agtgatttga ataatttaat       60

aaataagtta gagggctcag caggcccaga acgagccatt ttgtcagctg cagcagtcat      120

taactccgca gaggcctctg gtccctcgcc aggaagtttc ttcactggaa actgggaaga      180

cagggtggtt tagggttgaa ggtccgacgt ggaagagata agggctgaga cctgagtcac      240

ttctcacagg cattccctcc tcgtcccggg ctggcccttg cccccaccct gcaactcctg      300

gttgagatgg gctcagccaa gagcgtccca gtcacaccag cgcggcctcc gccgcacaac      360

aagcatctgg ctcgagtggc ggacccccgt tcacctagtg ctggcatcct gcgcactccc      420

atccaggtgg agagctctcc acagccaggc ctaccagcag gggagcaact ggagggtctt      480

aaacatgccc aggactcaga tccccgctct cctactcttg gtattgcacg gacacctatg      540

aagaccagca gtggagaccc cccaagccca ctggtgaaac agctgagtga agtatttgaa      600

actgaagact ctaaatcaaa tcttccccca gagcctgttc tgcccccaga ggcaccttta      660

tcttctgaat tggacttgcc tctgggtacc cagttatctg ttgaggaaca gatgccacct      720

tggaaccaga ctgagttccc ctccaaacag gtgttttcca aggaggaagc aagacagccc      780

acagaaaccc ctgtggccag ccagagctcc gacaagccct caagggaccc tgagactccc      840

agatcttcag gttctatgcg caatagatgg aaaccaaaca gcagcaaggt actagggaga      900

tcccccctca ccatcctgca ggatgacaac tcccctggca ccctgacact acgacagggt      960

aagcggcctt cacccctaag tgaaaatgtt agtgaactaa aggaaggagc cattcttgga     1020

actggacgac ttctgaaaac tggaggacga gcatgggagc aaggccagga ccatgacaag     1080

gaaaatcagc actttccctt ggtggagagc taggccctgc atggccccag caatgcagtc     1140

acccagggcc tggtgatatc tgtgtcctct caccccttct ttcccaggga tactgaggaa     1200

tggcttgttt tcttagactc ctcctcagct accaaactgg gactcacagc tttattgggc     1260

tttctttgtg tcttgtgtgt ttcttttata ttaaaggaag taattttaaa tgttacttta     1320

aaaaggt                                                               1327


<210> 4170
<211> 1416
<212> DNA
<213> Homo sapiens

<400> 4170
agcgatgcgg tttcactatg gtgtccaggc tggtctgcaa ctcccgggct caagcgatcc       60

tcccgccccg cctctcaaag tgctgggaag gtcccttcca ggcttaagca gcgataatgg      120

ttttcaagtt aaaaacaaag gaggaacagc acagcatgct gggctctgga tttaaagctg      180

agcgcttaag agtgaatttg agattagtca taaatcgcct taaactattg gagaaaaaga      240

aaacggaact ggcccagaaa gcaaggaagg agattgctga ctatctggct gctgggaaag      300

atgaacgagc tcggatccgt gtggagcaca ttatccggga agactacctc gtggaggcca      360

tggagatcct ggagctgtac tgtgacctgc tgctggctcg gtttggcctt atccagtcta      420

tgaaggaact agattctggt ctggctgaat ctgtgtctac attgatctgg gctgctcctc      480

gactccagtc agaagtggct gagttgaaaa tagttgctga tcagctctgt gccaagtata      540

gcaaggaata tggcaagcta tgtaggacca accagattgg aactgtgaat gacaggctaa      600

tgcacaagct gagtgtggaa gccccaccca aaatcctggt ggagagatac ctgattgaaa      660

ttgcaaagaa ttacaacgta ccctatgaac ctgactctgt ggtcatggca gaagctcctc      720

ctggggtaga gacagatctt attgatgttg gattcacaga tgatgtgaag aaaggaggcc      780

ctggaagagg agggagtggt ggcttcacag caccagttgg tggacctgat ggaacggtgc      840

caatgcccat gcccatgccc atgcctatgc catctgcaaa tacgcctttc tcatatccac      900

tgccaaaggg accatcagat ttcaatggac tgccaatggg gacttatcag gcctttccca      960

atattcatcc acctcagata ccagcaactc ccccatcgta tgaatctgta gatgacatta     1020

atgctgataa gaatatctct tctgcacaga ttgttggtcc tggacccaag ccagaagcct     1080

ctgcaaagct tccttccaga cctgcagata actatgacaa ctttgtccta ccagagttgc     1140

catctgtgcc agacacacta ccaactgcat ctgctggtgc cagcacctca gcatctgaag     1200

acattgactt tgatgatctt tcccggaggt ttgaagagct gaaaaagaaa acataggtct     1260

cttaaaccag gcaactttca cgttttggga gttgagactg agcaatttct ccttgtaaca     1320

aagaatctcc atgaaattct gtttcatctg ttaaccgtca ctcagcacaa cactccctct     1380

gggctctctt cctgctcctc cagattctgc tgcttt                               1416


<210> 4171
<211> 1021
<212> DNA
<213> Homo sapiens

<400> 4171
gagccaccgc gccgcggtac gcggttcccc gacggccgcc gcgaggggcg aggagcgagg       60

agcgaggggc gaagggcgag gccgagcagc cagatggcca ggccgctgtc cacccccagc      120

tcttcgcaga tgcaagccag gaagaaacac agagggatca tagagaaacg gcgtcgagac      180

cgcatcaaca gtagcctttc tgaattgcga cgcttggtcc ccactgcctt tgagaaacag      240

ggctcttcca agctggagaa agccgaggtc ttgcagatga cggtggatca cttgaaaatg      300

ctccatgcca ctggtgggac aggattcttt gatgcccgag ccctggcagt tgacttccgg      360

agcattggtt ttcgggagtg cctcactgag gtcatcaggt acctgggggt ccttgaaggg      420

cccagcagcc gtgcagaccc cgtccggatt cgccttctct cccacctcaa cagctacgca      480

gccgagatgg agccttcgcc cacgcccact ggccctttgg ccttccctgc ctggccctgg      540

tctttcttcc atagctgtcc agggctgcca gccctgagca accagctcgc catcctggga      600

agagtgccca gccctgtcct ccccggtgtc tcctctcctg cttaccccat cccagccctc      660

cgaaccgctc cccttcgcag agccacaggc atcatcctgc cagcccggag gaatgtgctg      720

cccagtcgag gggcatcttc cacccggagg gcccgccccc tagagaggcc agcgacccct      780

gtgcctgtcg cccccagcag cagggctgcc aggagcagcc acatcgctcc cctcctgcag      840

tcttcctccc caacaccccc tggtcctaca gggtcggctg cttacgtggc tgttcccacc      900

cccaactcat cctccccagg gccagctggg aggccagcgg gagccatgct ctaccactcc      960

tgggtctctg aaatcactga aatcggggct ttctgagctg ccccttcacc accccgcccc     1020

a                                                                     1021


<210> 4172
<211> 4006
<212> DNA
<213> Homo sapiens

<400> 4172
gcctcctctt gcgctgtcct gttaatggcg ggcagtagcc gctgagggga ttgcagataa       60

ccgcttcccg cacggggaaa gtctaccctg cctgccactt tctgctcgcc gtcagcgccg      120

gagctcgcca gcatgtctgt ggtaccgccc aatcgctcgc agaccggctg gccccggggg      180

gtcactcagt tcggcaacaa gtacatccag cagacgaagc ccctcaccct ggagcgcacc      240

atcaacctgt accctcttac caattatact tttggtacaa aagagcccct ctacgagaag      300

gacagctctg ttgcagccag atttcagcgc atgagggaag aatttgataa aattggaatg      360

aggaggactg tagaaggggt tctgattgta catgagcacc ggctacccca tgtgttactg      420

ttgagcaggt tcaattttat ttacaactga attcctgcgc agtggagaag taaaagaagc      480

cgcttgtctc tgtgagcaca gctatataca gtgtagaata aatgtggtag aaaagttttt      540

ttggttttat ctcttttgcg atccctaaat tgccaccttt ctattgtttg aatagtaaaa      600

ttaatatgaa gaactagata gtggtgtaaa caaatgtgat aatgtttatt tactttcggt      660

tctgctcata cttttttgta caacattaaa gaaaatggac tttttttatt ttaatttctc      720

attaaacttc taaaattctt ataggtgagg atcatttttc cccccacctt aggatggtga      780

atgttgcaac acaatgacag gtttaagtca gtcaagttta ttggaccctt gctttgatac      840

cattcttggg cacatactcc aagattgtat tagatttttg tgatgaagag cttccattac      900

ttctgaaaac tatatttatc tgagtgagtc caaggtgcaa ctcctaaatg aattgtgttg      960

cagagaactc ccagtataat tcactgacca gtacatttta taaccatcca ggccttggtt     1020

tgcaagcaac agaccttaaa catacaggaa actattaaaa ttggctcgat cagtagtcat     1080

aggaattggt ataagaagag actcatttag agctcagagt tttcttcaca taatgggggt     1140

attaattatt tgtgctgttg cgaaattatg tgtcttattc ttaaagccat ggtaaaaata     1200

gggatctgtg aaggaaattt ctaaaattgg atgtattagg ttttgaactc tgagattgca     1260

caaatattca attaacttga agttgtgtac atagagaaga aaatttggtt ttagcaaatg     1320

acagagcctt caaaaatatt tttggaataa tgtgaatcaa ccgaaaactg ggggcaaggc     1380

agaggacagg ttttctcagg ttaagagaaa aacgaaattt taaaaacttt aaaaaatact     1440

gataaattcg gatcaaattt gggggaataa aaaatattag agcaaaggag tttgctggtt     1500

gtgtcattat ttaatgatca aagtatagca tgtatgcctt attacagact tgttgactat     1560

aggcttaatg taaaaaggaa tcttgccaga tgtagctact taaggaaaaa agggttttta     1620

atagaaatga acttttgatt agtatggtgc cagtcacagg gctattttcc tgaatattgg     1680

gtgatgtcaa aggtatatga tacttgagga aatcaggcca agtgtagctg agcaattaat     1740

aaacactcaa gtttttttag ttggggtcat gtcaaaccct cacatggtgg ttaagtagtg     1800

actaactgtg catgtccttc atggtaggtg agcaccagtc tccatgatca aaaatgcccc     1860

agtttccttt gaaaaagcca ctagttctgt gaattgtcct tttccctcct gcccctaaca     1920

gtcctacccc tctagcctac attagcatat ttctcatgta atgtattttg ctggtaagct     1980

catccattag ctgcgtcctt cagctattcc tttagattgg aggaagtgga tatgaagatg     2040

gattgattca gctcaccttc catgattgct tttgagggaa aagctacagt ggccacattt     2100

cagatgttca cttttgcaat ttgtggaggg tggagagagg tagacttttg ttgtgtgttt     2160

tataaagtac tctcagtaag gagtgtttga gttgaagagt catctgattc gaggccactc     2220

atgttctttg taacttaaac tttgaccaag aaattcttca cttctcactt cttcacttct     2280

tcccaatata cagtaagtac gtgagccagt catccataca ctaaggccta gttgagaaaa     2340

acctttgatt caggatggct gggttactaa ccttgaaatg taagagatct ggttttgaat     2400

gtaaaagttg caacacacaa acggaagtct taaaaacttt ttgctctggt cagttacagg     2460

tggatcccca ataatctgtt tttggttttc tgatggaaat aatagaatta ggggaaatca     2520

aatctggttg gtaggtgtct acagtattag aagagggtat aagggcactg tttaacacta     2580

agttctaata cttccagaaa ctgtgcattc cagatctaca tactaaatgc tcttatcatt     2640

ttgaaatggg ctcttgatta atagacccat attttttagt ggcttctatg ttgtatattt     2700

gtctaaaatg aaagctcttt tgcgttctaa aactacaata tatgtcatct tattttccct     2760

gagtatccaa gtatagtgca gattctatgt aaaactacta aatgacactg gaatatgttt     2820

agtagattag ggggaaaaac tataaaggtt tatacaattg tttgtagtta catttaggat     2880

ggacttatcc ctttggagaa gagtgaagtt tgttttttcg ccatgtgatg aagaccactg     2940

tgatttttta aaaaagtaga taatacttaa aatggcgtaa taattctgca cttgaatttg     3000

tactgttaac agcacatttg gaagatttta aaacttttta ttgtcttata aatagcattc     3060

acttattatt ttggatattt aagggttcca ttaagttaac actgtatttg gacaaagtgt     3120

gaccaaatta gccagtctgt tttcttccat gtttaattag aagtgagagg tagaagtact     3180

tcaaattcaa caggccagca agcaatcggc ttaaaattcc ctttcttaaa tgttgtgctc     3240

ttatgttctc ggctttttaa tgactttatt tttacagtac ttgttcagtc acttgagatg     3300

aaatgcttgg ggtagctttt ccatcctcaa acttaatgtt tttactagtt catagtgttt     3360

ggaacagtat atgccaatca ctgagactgc atcagagttt gcaattttgt atgtttcatt     3420

gccaaagaag gcttagtggt tgttgactgt agtataagtc agctttctgt agcataagat     3480

ttgattttcc catacttact tcacttgtta tacatcactg attatttggg ttaaactgga     3540

ctcatttcaa gcagtttgct tttgttcaaa tcgtgatgag aaacctaata ctgtaatttg     3600

atttgagcca taaaacacat tttaatatta gcttgtatta tagttattaa gcttgttttt     3660

gtggaaaaaa acttactaaa acctaggtaa ctctagatta ggccagttca ggtgtatttt     3720

gtatcttagt aatggatcat atcgtaaaaa tagagataag ttgggaagat atattgatta     3780

tgctgttctg ttgagggaaa ggtcatgtat ttagaaattt aaacttttgg ttattgtgtt     3840

cacatcatag tattcaagca tcatttatag tttggttttg agaacttttc tggtattacg     3900

tttatggcaa atgtataaaa gaaacaagtt ttggttatat ttttatattt gtaaagtaag     3960

tttggttaaa gtgatcactg ttcttttttt attttattgt catttc                    4006


<210> 4173
<211> 877
<212> DNA
<213> Homo sapiens

<400> 4173
attccccttc agttgctcca tctgggcagc cagctcaggg cctcagtcca gagacaaagc       60

agaggcagac gattctagtt ttctttgctg taaatgccac actacatgga actagagaat      120

ttgggaatct gactcatcca atcaagccca ggctaaaggc aaatgaagaa aaggctcact      180

tcatggactc actttgcgtg cttgttaaat gtgctgtgtt gctcccaaga ccatgtaaag      240

cctactgacc actaacctcc ctcacagcag aaactagacg tcaggttaaa atgggcaact      300

ccgacagtca gtacaccctt caaggatcta aaaatcatag caatactatt actggtgcta      360

agcaaattcc ttgctccctg aaaatacgtg gcattcatgc aaaagaggaa aagtcattgc      420

atggatgggg tcacggaagc aacggagcag gttacaagtc caggtccctg gcccgaagct      480

gcctttctca ctttaagagt aaccagcctt acgcatcgag actcggtggc cccacatgca      540

aggtctccag aggtgttgcc tactccacgc acaggacaaa tgccccaggg aaggatttcc      600

agggcatcag tgctgctttc tcaactgaga atggcttcca ctctgttggc cacgagctgg      660

cagataacca catcacctcc agagactgca acggacacct tctcaactgc tacgggagga      720

atgagagcat tgcctccacc ccaccgggcg aagaccgcaa gagcccccga gtgctcatca      780

aaacgctggg gaagctggat gggtgtttaa gggtcgagtt ccacaatggt ggcaacccca      840

gcaaagtgcc tgcagaggac tgcagtgagc cggtgca                               877


<210> 4174
<211> 3112
<212> DNA
<213> Homo sapiens

<400> 4174
attgctggag cgcaggcggc ggagaggatg actgccgctg ccattctctc ttgagctagc       60

gagccgccgc caccctccac cctcccccgg cagggcggag aggagcggcc ggagtcagcg      120

atggtgcccg gcgaggagaa ccaactggtc ccgaaagagg atgtgttttg gagatgcaga      180

caaaatatct ttgatgaaat gaagaagaaa tttttacaga tagaaaatgc tgctgaagaa      240

cctagagtct tatgtattat acaagatact actaattcaa agacagtgaa tgaacggatc      300

actttaaatt taccagcatc tactccagtc agaaagctct ttgaagatgt ggccaacaaa      360

gtaggctaca taaatggaac ctttgacttg gtgtggggaa atggaatcaa tactgctgat      420

atggcaccac tggatcatac cagtgacaag tcacttctcg acgctaattt tgagccagga      480

aagaagaact ttctgcattt gacagataaa gatggtgaac aacctcaaat actgctggag      540

gattccagtg ctggggaaga cagtgttcat gacaggttta taggtccgct tccaagagaa      600

ggttctgggg gttctaccag tgattatgtc agccaaagct actcctactc atctattttg      660

aataaatcag aaactggata tgtgggacta gtaaaccaag caatgacttg ctatttgaat      720

agccttttgc aaacactttt tatgactcct gaatttagga atgcattata taagtgggaa      780

tttgaagaat ctgaagaaga tccagtgaca agtattccat accaacttca aaggcttttt      840

gttttgttac aaaccagcaa aaagagagca attgaaacca cagatgttac aaggagcttt      900

ggatgggata gtagtgaggc ttggcagcag catgatgtac aagaactatg cagagtcatg      960

tttgatgctt tggaacagaa atggaagcaa acagaacagg ctgatcttat aaatgagcta     1020

tatcaaggca agctgaagga ctacgtgaga tgtctggaat gtggttatga gggctggcga     1080

atcgacacat atcttgatat tccattggtc atccgacctt atgggtccag ccaagcattt     1140

gctagtgtgg aagaagcatt gcatgcattt attcagccag agattctgga tggcccaaat     1200

cagtattttt gtgaacgttg taagaagaag tgtgatgcac ggaagggcct tcggtttttg     1260

cattttcctt atctgctgac cttacagctg aaaagattcg attttgatta tacaaccatg     1320

cataggatta aactgaatga tcgaatgaca tttcccgagg aactagatat gagtactttt     1380

attgatgttg aagatgagaa atctcctcag actgaaagtt gcactgacag tggagcagaa     1440

aatgaaggta gttgtcacag tgatcagatg agcaacgatt tctccaatga tgatggtgtt     1500

gatgaaggaa tctgtcttga aaccaatagt ggaactgaaa agatctcaaa atctggactt     1560

gaaaagaatt ccttgatcta tgaacttttc tctgttatgg ttcattctgg gagcgctgct     1620

ggtggtcatt attatgcatg tataaagtca tcagtgatga gcagtggtac agcttcaatg     1680

atcaacatgt cagcaggata acacaagagg acattaagaa aacacatggt ggatcttcag     1740

gaagcagagg atattattct agtgctttcg caagttccac aaatgcatat atgctgatct     1800

atagactgaa ggatccagcc agaaatgcaa aatttctaga agtggatgaa tacccagaac     1860

atattaaaaa cttggtgcag aaagagagag agttggaaga acaagaaaag agacaacgag     1920

aaattgagcg caatacatgc aagataaaat tattctgttt gcatcctaca aaacaagtaa     1980

tgatggaaaa taaattggag gttcataagg ataagacatt aaaggaagca gtagaaatgg     2040

cttataagat gatggattta gaagaggtaa tacccctgga ttgctgtcgc cttgttaaat     2100

atgatgagtt tcatgattat ctagaacggt catatgaagg agaagaagat acaccaatgg     2160

ggcttctact aggtggcgtc aagtcaacat atatgtttga tctgctgttg gagacgagaa     2220

agcctgatca ggttttccaa tcttataaac ctggagaagt gatggtgaaa gttcatgttg     2280

ttgatctaaa ggcagaatct gtagctgctc ctataactgt tcgtgcttac ttaaatcaga     2340

cagttacaga attcaaacaa ctgatttcaa aggccatcca tttacctgct gaaacaatga     2400

gaatagtgct ggaacgctgc tacaatgatt tgcgtcttct cagtgtctcc agtaaaaccc     2460

tgaaagctga aggatttttt agaagtaaca aggtgtttgt tgaaagctcc gagactttgg     2520

attaccagat ggcctttgca gactctcatt tatggaaact cctggatcgg catgcaaata     2580

caatcagatt atttgttttg ctacctgaac aatccccagt atcttattcc aaaaggacag     2640

cataccagaa agctggaggc gattctggta atgtggatga tgactgtgaa agagtcaaag     2700

gacctgtagg aagcctaaag tctgtggaag ctattctaga agaaagcact gaaaaactca     2760

aaagcttgtc actgcagcaa cagcaggatg gagataatgg ggacagcagc aaaagtactg     2820

agacaagtga ctttgaaaac atcgaatcac ctctcaatga gagggactct tcagcatcag     2880

tggataatag agaacttgaa cagcatattc agacttctga tccagaaaat tttcagtctg     2940

aagaacgatc agactcagat gtgaataatg acaggagtac aagttcagtg gacagtgata     3000

ttcttagctc cagtcatagc agtgatactt tgtgcaatgc agacaatgct cagatccctt     3060

tggctaatgg acttgactct cacagtatca caagtagtag aagaacgaaa gc             3112


<210> 4175
<211> 1563
<212> DNA
<213> Homo sapiens

<400> 4175
cggtttgggg ggtgcgttgc ccggagacgg aaagtttggg agcccgagca ggctcggctg       60

cagcctcggg gagggggtcc agcgggtggc ggccctgggg atggggaagg agcaggagct      120

gctggaggcg gcccgcaccg ggcacctccc ggcggtggag aagctgctgt ccgggaagcg      180

gctctcctca ggctttgggg gcggcggcgg cggtggctct gggggcggcg gcggcggcag      240

cggcggcggc ggcggcggcc tcggctcttc cagccacccc ctctccagtc tgctcagcat      300

gtggagaggg ccaaatgtga actgtgttga cagcactggc tacacacccc tgcaccatgc      360

tgctttgaat ggccataagg atgtggtcga ggttcttctg aggaacgatg cgctgaccaa      420

cgtggctgac tcaaaaggct gctaccctct gcatttggca gcctggaaag gagatgccca      480

gatagtgcgg ttgctcatcc atcaagggcc ttcacacacc agagtcaatg aacagaacaa      540

tgacaacgag acagccctgc attgtgcagc gcagtatggc cacacagagg tggtgaaggt      600

gctcttagag gagctgacgg accccaccat gcgcaacaac aaattcgaga cccctttgga      660

cctggcagca ctgtacgggc gactggaggt ggtgaaaatg ctccttaatg cacaccccaa      720

cctcctgagc tgcaacacta agaagcacac ccctctgcac ttggcagcaa ggaatggcca      780

caaagccgtg gtccaggtcc tcctcgatgc tggcatggac agcaactacc agacggagat      840

gggcagtgct ttgcatgagg ctgctttgtt tggcaagacc gatgtggtgc aaatcctgct      900

ggctgcagga actgacgtca acataaaaga taaccatgga ctgactgccc tagacactgt      960

tcgggaactg ccttctcaaa agagccagca aatagcagca ttaattgaag atctcgacac     1020

cttgcagttt tacttcattt cctgcccctt tcagggcctg tgaggatgcc catgagctac     1080

cgctgtacag ttctcggccc cggctttctt ccaagagttg accaggaacc ctaaagcatc     1140

cagagtagac tgcgctgcca ctgcgcacat gctggtgccc gtcttcctcc taaggggcca     1200

ggccacatcc aagtgggcct ctgtcggggg cggggcggta ggtccgaaag aaaccgcaga     1260

cactacgatg cactcctcaa gctgtctttt gtgcttagat catccatagg tgtttcttct     1320

gcttgaagct gctatatcat ctttatttat tcagggtatt ttcatattgg aagccttggc     1380

tagtctgctc tagctctggg ttctgtttag agattggttt atttctgaat attcaagaaa     1440

ggaaaatgac tgggcctttc tttcttttct tctcctctgg gatgggtagt ctccctttcc     1500

tagaaaggtt attataactt taaggacagg cttcaagtgg gaaggcccct acttttgcac     1560

ttc                                                                   1563


<210> 4176
<211> 2352
<212> DNA
<213> Homo sapiens

<400> 4176
acctgcttgt gttcttgtat tcagggcact ggagtgcgtg ccagctggtc tggaagcagc       60

tccagcaagt cacttacacg gtggccaggg gcggcctgac tttcaatccg agacccgccg      120

ggaatgactt tgggataatc acaacctccg gtcctcagtt tccttacctg tgaaatgggg      180

ctgataacgc acagctgtgg gaagcaccgg cccaaacgca gggcttgggg acacgaccac      240

catccccgcc cacgggtccc cgcgccaggc ttcgctctcc acccctcccg ccgcgggccc      300

cagcgcttcg ccgaggtcgg ccccgggcgc caagaggcgt ggtcggcccg agcggaccct      360

cgcggcggcc atggcgtcgg tggtggaata caagggcctc agggccggct accactgcgg      420

ctactgcgat tccaaggagg gcaaagcgtc ctgcggcatg tgggcacatt ccatgacagt      480

acaggattat caggatctca tagaccgagg atggcgaagg tgccgacctt tacaatttca      540

gccttcaaaa tctcacaaga aggttttgaa aaaaatgttg aaatttctag ctaaagggga      600

ggttcccaaa ggaagttgtg aggatgagcc catggattcc acaatggatg atgctgttgc      660

gggtgacttt gcattgataa ataaactgga tatacagtgt gatcttaaaa cactcagtga      720

tgacatcaaa gagagtttag agagtgaagg aaaaaattca aagaaagaag aacctcagga      780

attacttcag tcacaagatt tcgtaggaga gaagttgggc tctggtgaac cgtcacattc      840

agttaaagtt cacacagttc ctaagccagg tgagggtggt gagatcatct ccaccaagtt      900

cgcagttcaa agccacactt ctggagtctt accaggtcta taaacgttac cagatggtta      960

ttcacaagaa cccacctgat acgccaaccg aaagccagtt cacaagattc ctttgcagtt     1020

cacccttgga ggcagagact ccccctaatg ggccagattg tggctatggc tcctttcacc     1080

agcagtactg gcttgacgga aagatcattg ctgtgggggt gattgacatc ctcccaaact     1140

gtgtatcatc tgtgtatttg tactacgatc ctgattattc gtttttgtct ttgggcgtct     1200

actctgcact acgagaaatt gcttttacta ggcagcttca tgagaaaact tctcaactca     1260

gctattatta tatgggtttc tacattcatt catgtcccaa gatgaaatat aagggtcagt     1320

atagaccttc tgatttgctg tgccctgaga catatgtttg ggtacccatt gagcaatgcc     1380

tgccttcact tgaaaactcc aagtactgcc gtttcaacca ggacccagaa gcagtggatg     1440

aggatcgcag tacggaacct gaccgattgc aggtgtttca caagagagcc atcatgcctt     1500

acggtgttta taagaaacag cagaaagacc caagtgagga ggctgctgtt ctgcagtacg     1560

ccagcctggt ggggcagaag tgctccgagc ggatgctgct gttcagaaac tgacctgttc     1620

acctctgccg ggaagttcct gtgttgtgct gatgatttgt gccaggatac atattcagta     1680

cctgtgggga aataactgtc accacccaca aattagacat tttttatttt gactatctat     1740

ggcttttaaa aaatattttg tggcaatgta tctgtgagaa tctcatagtt aatataaaga     1800

ttttaaaact gcattatgac ctagccccca taattgggat ttatcatttt ggaggattct     1860

ttctagagca agatacgctc aaattctcct gtttgtattt tgtaaaatga agaagtgaat     1920

ctaagtaact taatcacagt tgtgcatttt ttttggttct gttagagaaa ttaaaacaga     1980

ctgtttcctc aggcccattt taaactgaac ttatgctagg aaaccttaag tatggggaag     2040

gtagaaagtt catttcatca cttagaaaat atgtcttctc aagaacaaaa ctgtgctgtt     2100

acaactcagt gttcaatgtg aaattgctgc caaatgttat gtagtttaat agagaacttg     2160

aaaaaataaa acattaaaat ggagcttgtg ttagcatcag gtatccattt gttcaggaca     2220

gtcctgttca tgtctgttgt cttggcatag ttttttcccc tagaatatag tactcccttt     2280

tactctaaaa aatatcccag tttggacaat aaaatacata attactctag ttatattatt     2340

tgctttactt ct                                                         2352


<210> 4177
<211> 2106
<212> DNA
<213> Homo sapiens

<400> 4177
gaagaaacct tcagccaaac agcagaagga ggtagagaag gttaaacccc agtgtaagga       60

agttcatcag accctgattc tggacccagc acaaaggaag agactccagc agcagatgca      120

gcagaaagag ctgggaacct ttgctcaaag ctccatcgcc cttcaccatc agtacaaccc      180

caagtttcag accctgttcc aaccctgtaa cttgatggga gctatgcagc tgattgaaga      240

cttcagcaca catgtcagca ttgactgcag ccctcataaa actgtcaaga agactgccaa      300

tgaatttccc tgtttgccaa agcaagtggc ttggatcctg gccacaagca aggttttcat      360

gtatccagag ttacttccag tgtgttccct gaaggcaaag aatccccagg ataagatcct      420

cttcaccaag gctgaggaca acaagtacct tctaacctgc aagactgccc gccaactgac      480

agtgagaatc aagaacctca acatgaacag agctcctgac aacatcatta aattttataa      540

gaagaccaaa cagctgccag tcctaggaaa atgctgtgaa gagatccagc cacatcagtg      600

gaagccacct atagagagag aagaacaccg gctcccattc tggttaaagg ccagtctgcc      660

atccatccag gaagaactgc ggcacatggc tgatggtgct agagaggtag gaaatatgac      720

tggaaccact gagatcaact cagatcaagg cctagaaaaa gacaactcag agttggggag      780

tgaaactcgg tacccactgc tattgcctaa gggtgtagtc ctgaaactga agccagttgc      840

cgaccgtttc cccaagaagg cttggagaca gaagcgttca tcagtcctga aacccctcct      900

tatccaaccc agcccctctc tccagcccag cttcaaccct gggaaaacac cagcccaatc      960

aactcattca gaagcccctc cgagcaaaat ggtgctccgg attcctcacc caatacagcc     1020

agccactgtt ttacagacag ttccaggtgt ccctccactg ggggtcagtg gaggtgagag     1080

ttttgagtct cctgcagcac tgcctgctat gccccctgag gccaggacaa gcttccctct     1140

gtctgagtcc cagactttgc tctcttctgc ccctgtgccc aaggtaatga tgccctcccc     1200

tgcctcttcc atgtttcgaa agccatatgt gagacggaga ccctcaaaaa gaaggggagc     1260

cagggccttt cgctgtatca aacctgcccc tgttatccac cctgcatctg ttatcttcac     1320

tgttcctgct accactgtga agattgtgag ccttggcggt ggctgtaaca tgatccagcc     1380

tgtcaatgcg gctgtggccc agagtcccca gactattccc atcgccaccc tcttggttaa     1440

ccctacttcc ttcccctgtc cattgaacca gccccttgtg gcctcctctg tctcaccctt     1500

aattgtttct ggcaattctg tgaatcttcc tataccatcc acccctgaag ataaggccca     1560

catgaatgtg gacattgctt gtgctgtggc tgatggggaa aatgcctttc agggcctaga     1620

acccaaatta gagccccagg aactatctcc tctctctgct actgttttcc ccaaagtgga     1680

acatagccca gggcctccac cagtcgataa acagtgccaa gaaggattgt cagagaacag     1740

tgcctatcgc tggaccgttg tgaaaacaga ggagggaagg caagctctgg agccgctccc     1800

tcagggcatc caggagtctc taaacaactc ttcccctggg gatttagagg aagttgtcaa     1860

gatggaacct gaagatgcta cagaggaaat cagtggattt ctttgagcta ggagaataag     1920

agtctggaga ctgggagcct tcacttcggc ctccgattgg tggcgcatag ggtgtaacca     1980

ataggaaacc cctaaagggt acttaaaccc cagattttgc aactggggct cttgagcagc     2040

ttgctttagc ctgctcccac tctgtggaat atacttttgc ttcaataaat ctgtgctttt     2100

attgct                                                                2106


<210> 4178
<211> 1027
<212> DNA
<213> Homo sapiens

<400> 4178
atggctgata aatccaaatt tattgaatac attgacgaag ctttagaaaa atcaaaagaa       60

actgcactct ctcatttatt tttcacctat caggggattc cttaccccat caccatgtgc      120

acctcagaaa ctttccaagc gctggacacc ttcgaagcca gacatgatga catcgtgcta      180

gcatcttatc caaagtgcgg ttcaaactgg attctccaca ttgtcagtga attaatatat      240

gctgtttcta aaaaaaagta taaatatcca gaattcccag ttcttgaatg tggggattca      300

gaaaaatatc agagaatgaa aggctttcca tcaccaagga ttttggcaac tcacctccac      360

tatgacaaat tacctgggtc tatcttcgag aataaagcca agatattggt gatatttcga      420

aaccctaaag atacagcagt atcttttttg catttccaca acgatgtccc cgatattcca      480

agctatggct cttgggatga attcttcaga cagttcatga aaggacaagt ttcttgggga      540

aggtattttg attttgcaat caattggaac aaacatcttg atggcgacaa tgttaagttc      600

atattatatg aagacctgaa agagaatctg gctgctggaa taaaacagat tgctgagttc      660

ttgggattct ttctaactgg ggagcaaatt caaactatct cagtccagag caccttccaa      720

gccatgcgtg cgaagtctca ggacacacac ggtgctgtcg gcccattcct tttccgcaaa      780

ggtgaagttg gtgattggaa aaatttgttc agtgaaattc agaaccagga aatggatgaa      840

aaattcaaag agtgcttagc aggcacctcc ctcggagcaa agttgaagta tgaatcatat      900

tgccagggtt gattccagtc aattcagcag gcctagattt attttcctta ataataatta      960

agtgtaaata attaaatgat aattcaatca aataatcaaa taataattaa acaatattga     1020

aatctaa                                                               1027


<210> 4179
<211> 1177
<212> DNA
<213> Homo sapiens

<400> 4179
gtgaccagag cggttgcggg ctgagcggtt tcgagccggc gtcggggagc ggcggtaccg       60

ggcggctgcg gggctggctc gacccagctt gaggtctcgg cgtccgcgtc ctgcggtgcc      120

ctgggatccg ccgacatgaa tcccatcgta gtggtccacg gcggcggagc cggtcccatc      180

tccaaggatc ggaaggagcg agtgcaccag ggcatggtca gagccgccac cgtgggctac      240

ggcatcctcc gggagggcgg gagcgccgtg gatgccgtag agggagctgt cgtcgccctg      300

gaagacgatc ccgagttcaa cgcagacacc tcattgcttt ctgactgacc aaggcgcagc      360

gcagtttgca gcagctatgg gggttccaga gattcctgga gaaaaactgg tgacagagag      420

aaacaaaaag cgcctggaaa aagagaagca tgaaaaaggt gctcagaaaa cagattgtca      480

aaaaaacttg ggaaccgtgg gtgctgttgc cttggactgc aaagggaatg tagcctacgc      540

aacctccaca ggcggtatcg ttaataaaat ggtcggccgc gttggggact caccgtgtct      600

aggtaggacc aagggatgcc tcctgcccct tcccctcttc tcccgccctc aggctttcct      660

cactctctat tccctgcccc tctccgtttc ttgctgcgtt ccctttctgc ttttggtgca      720

gctccaggat gtctgggagt gacaatgggg ttggaagggg ttgttcgggg tgctgccttg      780

agagggtgtt tgtatctggc gccactgttt ttactagatt gcatgccttt ttggaacaac      840

ttggggagag aagtggagac agggatgcta acgttgcccc cagtctaccc tgtcgtgatt      900

ctgtcttctc tttagccaca gtttcaggat ctgcagactt acttgagtaa gacttactcc      960

cgagacatgg gctctgatta gcaatctgag aaatctgaga ctgcagttgt tagatctgag     1020

cagcatgaaa gtgacatact tctacagaca cattatagat tgagatgttg tttacattaa     1080

cggggaagca cgccatctca ttcccaggag tgggtgagag gcagggctgg ggggctgtat     1140

gtttcactcc gtgcagactt tcacacttgt catgcag                              1177


<210> 4180
<211> 1423
<212> DNA
<213> Homo sapiens

<400> 4180
gaaacgtgaa gaaggtgaag atggcggtgg ccagggccgg ggtcttggga gtccagtggc       60

tgcaaagggc atcccggaac gtgatgccgc tgggcgcacg gacagcctcc cacatgacca      120

aggacatgtt cccggggccc tatcctagga ccccagaaga acgggccgcc gccgccaaga      180

agtataatat gcgtgtggaa gactacgaac cttacccgga tgatggcatg gggtatggcg      240

actacccgaa gctccctgac cgctcacagc atgagagaga tccatggtat agctgggacc      300

agccgggcct gaggttgaac tggggtgaac cggatagacc atgaagctga aggaacttga      360

gcggccagct gtccaggcat ggagcccagc cagccaatac cctttgtatc tggccacagg      420

aacatctgcc caacagctag attcctcctt cagcacaaat ggcacattgg aaatatttga      480

ggttgatttc agggaccctt ctctggactt gaaacacaga ggagtccttt ctgccttgag      540

cagggcaacc tcctggcttc aggggccagc gattctgaaa tcttcatttg ggatctgaat      600

aacttgaatg tgccaatgac cctgggatcc aagtcacagc agcctccaga ggacatcaag      660

gcactgtctt ggaaccggca agcccaacac attctgtctt ctgctcaccc cagtggcaag      720

gcagttgtgt gggatctcag gaagaatgaa cctatcatca aagtcagtga tcacagcaac      780

aggatgcact gctcaggcct ggcctggcat cctgacatag ccacccagtt agtgctgtgc      840

tcagaggatg atcgacttcc cgtgattcag ctgtgggact tgcgctttgc ctcctcgccc      900

ttgaaggtgc tggagagcca cagcaggggg atcttgtcag tgtcatggag ccaggctgat      960

gctgagctgc tgctcactag tgctaaggac agccagatct tgtgccggaa cctggggagc     1020

agtgaggtgg tatataagct accaacacag agcagctggt gctttgatgt gcagtggtgc     1080

cctcgggacc cttcagtgtt ctctgctgcc tccttcaacg gctggatcag tttgtactct     1140

gtgatgggta ggagctggga agtccagcat atgagacagg ctgacaaggt ttgaagggct     1200

tggtagagaa tgctggaggg aaggggctgt ctctgtttgt gggagagaga catatggctt     1260

gagaagcgga gatattggag attgggagac cagggcccgg ggtttgggag ggctgcacct     1320

ttgccctagt gcccatcttc ctgaaaggat gttagtttct gccacaatgt gaagaaggcc     1380

ttcaccttga ctcttgttat tggatgggcc ctgtagtatt tca                       1423


<210> 4181
<211> 748
<212> DNA
<213> Homo sapiens

<400> 4181
gcctgagctg agtgaggccg aggccgggag gccgtgcccg gagtaaggcg aaagagaatg       60

aaagacgtag ataacctcaa aagtataaaa gaagaatggg tttgtgaaac aggatctgat      120

aatcaacctc ttggtaataa tcaacaatca aattgtgaat attttgttga tagccttttt      180

gaggaagctc agaaggttag ttccaaatgt gtgtctcccg ctgaacagaa gaaacaggta      240

gatgtaaata taaaattatg gaaaaacgga ttcaccgtca acgacgattt cagaagttat      300

tccgatggtg ccagtcagca gtttttgaac tccatcaaaa agggggaatt accttcagaa      360

ttacagggaa tttttgataa agaagaggtg gacgttaaag ttgaagacaa gaaaaatgaa      420

atatgtttgt ctacgaagcc tgtgttccag cccttttcag gacagggtca cagactagga      480

agagtaagcc atatcaaaga cttcattgaa aaataccaag gatctcaaag aagtcctccg      540

ttttccctgg caacagctct tcctgtcctc aggttgctag atgagacact cacactggaa      600

gaagcagatt tacagaatgc tgtcatcatt cagagactcc aaaaaactgc atcttttaga      660

gaactttcag agcactgatt tttgatagac taagtggaaa atttgcagag aaatgatggt      720

tgtaagtgga catgcaaacc aaaattgg                                         748


<210> 4182
<211> 1460
<212> DNA
<213> Homo sapiens

<400> 4182
attcgtcacc aggaggaaga cggagctggc tgcccagccc aaaggcccat gaggggatgc       60

agttatgggc tctgtcgccg tggattgtta ttttgtgtca ttttagatga tcagagtggt      120

aagaaaagtg taaatgataa aaatctgaaa aagacagtgg aggatgaaga tcaagatagt      180

gaggaagaaa aagataacga cagttacata aaagagagaa gtgatattcc ttctggaaca      240

agtaagcact tacagaaaaa agcaaagaaa caagccaaaa agcaagccaa gaaccaacga      300

agacaacaaa aaattcaagg aaaagttctt catttaaatg atatttgtac tattgaccat      360

cctgaagaca gtgaatatga agctgaaatg tcacttcaag gagaagtaaa tattaaatcc      420

aaccatattt cacaagaggg tgttatgcat aaagaatatt gtgtcaacca gaaagatttg      480

aatggccaag caaaaatgat cgaaagtgta actgacaatc aaaaatccac agaggaagta      540

gatatgaaaa atatcaacat ggataatgat ctggaggttt taacatcttc tcccactagg      600

aatttaaatg gtgcctacct aacggaaggg agcaatggag aagtggacat ttccaatggt      660

ttcaaaaacc taaatttgaa tgctgctctt catcctgatg aaataaatat agagattctg      720

aatgatagtc atactcctgg aacaaaggtg tatgaggttg taaatgaaga tccagaaact      780

gctttctgta ctcttgcaaa cagggaagtt ttcaatactg atgagtgttc aatccaacat      840

tgtttatatc agttcacccg taatgagaaa cttcgagatg cgaataaact gctttgtgaa      900

gtatgcacac ggagacagtg taatggacca aaggcaaata taaaaggtga aaggaagcat      960

gtttacacca atgccaaaaa gcagatgcta atttctcttg ctcctcctgt tcttactctt     1020

catttaaaga gatttcagca ggctggtttt aacctacgca aagttaacaa acacataaag     1080

tttccggaaa tcttagattt ggctcctttt tgcaccctta aatgtaagaa tgttgcagaa     1140

gaaaatacaa gggtactcta ttccttatat ggagttgttg aacacagtgg tactatgagg     1200

tcggggcatt acactgccta tgccaaggca agaaccgcaa atagtcatct ctctaatctt     1260

gttcttcacg gtgatattcc acaagatttt gaaatggaat caaaagggca gtggtttcac     1320

atcagcgaca cacatgtgca agctgtgcct acaactaaag tactaaactc acaagcgtac     1380

ctcctatttt atgagagaat actgtaataa tatcaaaagc actttttctg gaaacacatt     1440

tatggctttt ataatggctg                                                 1460


<210> 4183
<211> 3328
<212> DNA
<213> Homo sapiens

<400> 4183
gagccgcggt cacgcgcccg cccgaaggct cctgtcggga cagggcgccg ccccgtgtcg       60

gcccccgcag agctcgcggc ccccgcctgt ccgggcgccg ccatggagcg catcgagggg      120

gcgtccgtgg gccgctgcgc cgcctcaccc tacctgcggc cgctcacgct gcattaccgc      180

cagaatggtg cccagaagtc ctgggacttc atgaagacgc atgacagcgt gaccgttctc      240

ttattcaact cttctcggag gagcctggtg ttggtgaagc agttccggcc agctgtgtat      300

gcgggtgagg tggagcgccg cttcccaggg tccctagcag ctgtagacca ggacgggcct      360

cgggagctac agccagccct gcccggctca gcgggggtga cagttgagct gtgtgccggc      420

ctcgtggacc agcctgggct ctcgctggag gaagtggctt gcaaggaggc ttgggaggag      480

tgtggctacc acttggcccc ctctgatctg cgccgggtcg ccacatactg ggacgctacg      540

atgggctcct gaccccagct gaggtcttgg ggaaggagga gggtgtcaca gacccccacc      600

cccaccagct gagcaccagc ctccacagcc tcctccagag gccagggccc gctccactgg      660

gagaagcacc ggaagtctct gcacctgtca gcctggcaca tgggccactc agggttgagc      720

ctggggccct cccacctcag cagcctcaag gacttcacct gggcacgttc ctggctggat      780

gggtggactc ccaagttaaa ggcagcattt ccacgctggg ccaggcacgg tggctcacgc      840

ctgtaatccc agcactttgg gaggccgagg caggcggatc acctgaggtc aggagttcga      900

gaccagcctg accacatgga gaaaccccgc ctctgctaaa agtacaaaat tagccaggcg      960

tggtggcagg agcctgtaat tccagctact caggagactg aggcaggaga atcgcttgaa     1020

cccaggaggc ggaggttgcg gtgagccgag atcgcgccat tgcactctag cctgggcaac     1080

aagagcgaaa ctctgtctca acaaaacaga atttccatgc cgaagggtgg acttgggtgt     1140

gaaggatggg ccttggtttt ctgcaggtgt ctaccccgtg gtgggccacg cccactgtgc     1200

ccccagctcc ccagcccata gtactgagca cagccgggag gcatgggagg ggctggagtc     1260

cccttggtcc ccctggagga ggtgggcctg ggcaggttcc tggcagaggg accgcacagg     1320

ctctcagggc aagtggtcaa gcagccctgg ccgcggtggt tctactggta cagcctctgg     1380

gccacagcct gattgtgagg gtgctgggga gccaaggagg gctctgggaa gtaggcatcc     1440

tgcttagact cgcatcggga agagcaggcc gtggcttcag ggatgcagga ctggagatgc     1500

tgctgactag gggtcagggt gtccgtctct gagggcctga tggggggctg gactgacagc     1560

aaagttcacc caccctgtgg cagggcccgt ggctccctgt ctctgattct ggaggtgagc     1620

caggcctctt acctgccgct gcaaaggaca aggcccaggg aggcagtcag cttggggcgt     1680

gatggagtga agttggaacg tgccctgggg tgggggaggc gttgcccagc ctggctggca     1740

gattcctctc agcccgggcc aagggccggg cctgtctcct tcacaagccg gcggaaaccg     1800

gggctggaaa ccccagaccc gccacttccc tcagaggcgc agccgcggcc gccgccggaa     1860

atgggccatc aggaaggggt ctgcgggagg tgaggggcta gagggcaagg aagcagctgg     1920

gtaaggtcgg tctggggtga gtccccccgg aggtggggag gccttggggg tggggcatgg     1980

aagcccccag ttctgtccct gcccctgtat gttgggtaca tctcagaggg cggcctctac     2040

cctgcaggcc tccggctggc cttggttcat ggcacccgac agcccctcct gcggcgagcc     2100

agggctcccc caccccctgg tcatcttccc agatgcccct cagtcccgtt tctccccaga     2160

tccacacctg gccctccccc tcctgttcca gaatgcagcc cagcccctct gccatcctgt     2220

cctcctagcc cgtggtctcc ctccacacac gccagtccag gctccttccc ttggtgcctg     2280

acccctcctg gctgccagca gcccccttct ggccactgcc cactgaggga gggggcttcc     2340

tcttacccct ccccagcctg ggccactggg cctggtactg aggacctcgc tgccacccca     2400

ccccactctg ccatgctacg gggggtgggg gggcggtcag tgcatgctgt tcctagtctg     2460

aaacttgtgt cctgtgggtg cctggtgggg aacccttgcg ggaaggcctg gtgggtttgt     2520

ccctgcttcc cagccagcct gtgtccccgg gtatgggctg gggtctggca tgggcctctg     2580

cagctggcca cagactgagg ggctccaaac agcactggga acagcctcag ggtatctggt     2640

tgggggctgc agacaggggt ggggtcttct gcttggcctt gacaggttgc aggcaggttg     2700

tcagccggat ctgcaatctc atgggggctt ggggtcttcc cggctcacga ggttatggca     2760

gaattcagct cctggtggct ggggactggg tcccacctcc ctgctggctg ttggcccttc     2820

ccagcatggc ggttgcttcc ccttcagggc cagcaggact ggcctgaatt tctccctttc     2880

tggcgttgaa acaccctctg gagggcttcg tgatcgggcc atgcccgcct aggatgctct     2940

cccttctgat gagctcaagt caccggttag ggtccttaat cacatcgaca acacccaccc     3000

cacctggtct ggagtgggac tgactggctc cagacagacc atgttctaca cagaggtgac     3060

agatgcccag cgtagcggtc caggtggggg cctggtggag gagggtgagc tcattgaggt     3120

ggtgcacctg cccctggaag gcgcccaggc ctttgcagac gacccggaca tccccaagac     3180

cctcggcgtc atctttggtg tctcatggtt cctcagccag gtggccccca acctggatct     3240

ccagtgagac tccagggttc tagacagagg ccagtcttgg ccactcaccc cacaccccgc     3300

ggaccccaat aaaggcttgc atagctcc                                        3328


<210> 4184
<211> 982
<212> DNA
<213> Homo sapiens

<400> 4184
agaccttgaa tcgaaaccca ggctcctgca ggcactggca cagctacagc gagggcctcg       60

gccatccaag ggtctcccag cagccttgga agtggagttt actctcccct tgaggaagct      120

gaaggtcaga aagggagaga cgattgcctg aggtcacaca gctgatggac agtagagctg      180

ggttatgaac tcgaatgcat ctgagcatac agggatgctg agaacttgct ggagtcacag      240

ccactgggat cctttctcat cagggtcagt cacagccatg tgggctacac actctcctac      300

aagtaaggcc tgggccggga tccagggcag gggcaggtgg gctcttgggt ttccttggag      360

ggggcaaggg gtgcttcatg tcatagcttc tcagaaagca gcagtaactg aggctgtgga      420

tctgagaacg ggagctgcta gccaagcaat gagtgaagct tttgtccgta gtggcatgtt      480

ttatctgagg ccagcctttg tactcctgtg ttataaatgg gggaaactga ggcacagcga      540

ggttagtaac ctgctgggtg ttgcatggcc agtgagtgaa gaagcctgca tgggaacctg      600

gggtagtctg gctgtagcag tgacgctgcc ggcccaaggg ctggggactt ggggcaggga      660

tgagggggag taggatgtcc cagcccccgc agtgtctccg cagagcccaa agcagctgct      720

gccatttcat ggtgaagctc ttggatgatg ggactttcat gatccccggg gagaaggtgg      780

cccacacctc gctggacgcc ctggtcacct tccaccagca gaagccaatt gagccgcgca      840

gggagctgct gacacagccc tgcaggcaga aggatcccgc aaacgtggat tacgaggatc      900

tcttcctcta ctccaacgca gtggccgagg aagctgcctg cccggtgtct gcccctgagg      960

agacggagtc ttgctttgtc ga                                               982


<210> 4185
<211> 1607
<212> DNA
<213> Homo sapiens

<400> 4185
gaggtggggg cgggggcctt accccaccct ggcaccggca ggcgcgggcg gatgggggga       60

tgtcgcctag agccccccgg ccggcccaca aactcccgtc ccccttccgg ctctgcctgg      120

acgtccctgc gggccccggg ggaaagcacc caacttctcc cgcctcggct tctagcagaa      180

acgtgacggg gctggacttt gatcgccgag ggctctctgc tcttcagagt ctgcttggaa      240

cgggataaga gggatggtgc catccaggga agctctgctg ggaccaggca caactgccat      300

taggtgcccc aagaaattac agaaccaaaa ttacaagggc catggattgt caaagggaaa      360

agagcgagag cagagagcat cgatccggtt caagaccacc ctcatgaaca cactcatgga      420

cgtccttcgc cacaggccag gatgggtgga agtgaaggac gaaggggagt gggatttcta      480

ctggtgtgac gtcagctggc tccgggagaa cttcgaccac acctacatgg atgaacatgt      540

gcggatcagt cacttccgga accactatga gctgacccgg aagaactaca tggtgaagaa      600

cctgaagcgg ttccggaagc agctggagcg tgaggcagga aagctggagg cagccaagtg      660

tgacttcttc cccaaaacct ttgagatgcc ttgcgagtac cacctgtttg tagaggagtt      720

tcgcaaaaac ccaggaatca cctggatcat gaagcctgta gcccggtctc aagggaaagg      780

catcttcctc ttccgtaggc tgaaggacat cgtggactgg aggaaggaca caagaagctc      840

tgacgaccag aaagatgata ttcccgtgga gaactatgtg gctcagcgtt acattgaaaa      900

tccttacctg ataggaggcc gcaagtttga cctgcgtgtc tatgtgctgg tgatgtcggt      960

gtttgctgaa tgcctgctgt ggtctgggca caggagacag gatgttcacc tcaccaacgt     1020

ggctgtgcaa aaaacatctc ccgactacca cccaaagaag ggctgcaagt ggacgctgca     1080

gcgcttccgg cagtacctgg cgtccaaaca cgggcccgag gcagtggaga cactcttcag     1140

ggacatcgac aacatctttg tcaaaagcct gcagagtgtg cagaaggtga tcatcagtga     1200

caagcactgc ttcgagctgt acggctatga catcctcatc gaccaggacc tcaagccgtg     1260

gctcctggag gtcaatgcgt ccccatcact gacagccagc agccaggaag actatgagct     1320

caagacctgc ctcctggaag acaccctgca tgttgtggac atggaagcga ggctcacggg     1380

aagggagaag cgagtcgggg gctttgacct catgtggaat gatggccctg ttagcagaga     1440

ggagggggct cctgacctgt cgggaatggg aaactttgtg accaacacac atctcggctg     1500

cgtcaacgat cggaagaaac aactgaggca gctcttctgc tcccttcaag ttcagaagaa     1560

agcttccagt tgatccccag ctgccaggag gaaatcagcc ttagcag                   1607


<210> 4186
<211> 1173
<212> DNA
<213> Homo sapiens

<400> 4186
aagttaagga ggggaggggg tggagggaaa agcaagccag gaggtgcttg cggccgcttc       60

tagtagtttc caggcgctgc cgggcggctg gcactaagcg gtcctgaggc tgtggctacg      120

gctgctccgg agctggtggc gccgcgatag gagagccgat ggccaagtgg ggtgagggag      180

acccacgctg gatcgtggag gagcgggcgg acgccaccaa cgtcaacaac tggcactgga      240

cggagagaga tgcttcaaat tggtccacgg ataagctgaa aacactgttc ctggcagtgc      300

aggttcaaaa tgaagaaggc aagtgtgagg tgacggaagt gagtaagctt gatggagagg      360

catccattaa caatcgcaaa gggaaactta tcttctttta tgaatggagc gtcaaactaa      420

actggacagg tacttctaag tcaggagtac aatacaaagg acatgtggag atccccaatt      480

tgtctgatga aaacagcgtg gatgaagtgg agattagtgt gagccttgcc aaagatgagc      540

ctgacacaaa tctcgtggcc ttaatgaagg aagaaggggt gaaacttcta agagaagcaa      600

tgggaattta catcagcacc ctcaaaacag agttcaccca gggcatgatc ttacctacaa      660

tgaatggaga gtcagtagac ccagtggggc agccagcact gaaaactgag gagcgcaagg      720

ctaagcctgc tccttcaaaa acccaggcca gacctgttgg agtcaaaatc cccacttgta      780

agatcactct taaggaaacc ttcctgacgt caccagagga gctctataga gtgtttacca      840

cccaagagct ggtgcaggcc tttacccatg ctcctgcaac attagaagca gacagaggtg      900

gaaagttcca catggtagat ggcaacgtct ctggggaatt tactgatctg gtccctgaga      960

aacatattgt gatgaagtgg aggtttaaat cttggccaga ggggtctcac tgtcactcag     1020

gctagagtgc agtggcataa tcacagcaaa ctgcagcctt aacctcccag acccaaacga     1080

tcctcctgct tcagcttccc aagtagctga gactacgtgt gccaccatgc cagctttttt     1140

tttttttttt ttttttttac ttttttactt ttt                                  1173


<210> 4187
<211> 2059
<212> DNA
<213> Homo sapiens

<400> 4187
aaagtttacg ggatgtaggc ggcggcggcg gtagtggtag cggttattcg gcggcccgcg       60

gcggaccatg gccctggccc tggcccggcg tcgctgggct ttcctcacgg cgtccccgag      120

cagcgtcgca gagcgggccg acttccggga aggaactgac cagcgactga gcggcggccg      180

gcgcgcttag cgccctgaac atgcggcagt ccctgcgggc gaccccgggc tccggacagg      240

cggcggcgga ggcggcggct cgggagggaa ggaggcggcg gcgccggcgg aggtggcggc      300

ggaggtgcag gggaagtacg tgaagaagga gacgtcgcct ctgcttcgga atcttatgcc      360

ttcattcatc cggcatggtc caacaattcc aagacgaact gatatctgtc ttccagattc      420

aagccctaat gccttttcaa cttctggaga tgtagtttca agaaaccaga gtttccttag      480

aactccaatt caaagaacac ctcatgaaat aatgagaaga gaaagcaaca gattatctgc      540

accttcttat cttgccagaa gtctagcaga tgtccctaga gagtatggtt cttctcagtc      600

atttgtaacg gaagttagtt ttgctgttga aaatggagac tctggttccc gatattatta      660

ttcagacaat ttttttgatg gtcagagaaa gcggccactt ggagatcgtg cacatgaaga      720

ctacagatat tatgaataca accatgatct cttccaaaga atgccacaga atcaggggag      780

gcatgcttca ggtattggga gagttgctgc tacatcttta ggaaatttga ctaaccatgg      840

ttctgaagat ttaccccttc ctcctggctg gtctgtggac tggacaatga gagggagaaa      900

atattatata gatcataaca caaatacaac tcactggagc catcctcttg agcgagaagg      960

acttcctcct ggatgggaac gagttgagtc atccgaattt ggaacctatt atgtagatca     1020

cacaaataag aaggcccaat acaggcatcc ctgtgctcct agtgtacctc ggtatgatca     1080

accacctcct gtcacatacc agccacagca aactgaaaga aatcagtccc ttctggtacc     1140

tgcaaatcca tatcatactg cagaaattcc tgactggctt caggtttacg cacgagcccc     1200

tgtgaaatat gaccacattc tgaagtggga actcttccag ctggctgacc tggatacata     1260

ccagggaatg ctaaagttgc tcttcatgaa agaattggag cagattgtta aaatgtatga     1320

agcatacaga caagcccttc ttacagagtt ggaaaaccga aagcagagac agcagtggta     1380

tgcccaacaa catggaaaaa atttttgagc tgatttttta aaaatttaag ttttgtaaga     1440

gctttaaaat attttcacag ataaaaaatt gcaaacaagt actctggtta ataaatgctg     1500

cttcctttgt ggaaattata aaattctaac tttacatgta ttttgttatt agaaattttc     1560

ttttattgaa tgagaaaaat tagtctatca ttttaagagc caatatggca aacactttca     1620

aatactgtat attaggaaac tgttttggta ttcttgatgg aaaaaaacgc agcggaaatg     1680

tcattatgaa cagatgttaa ataggaaatt attacttgtt aacttcttac agcagtagta     1740

ccttctttaa aaaaaaaaaa gaatctgcgg tattttttta aaaaaaaagt ttaccgctgt     1800

agtgtgaaat attgtctgga aagggatggt ttaaatatta ccatgatgta gttgaaatat     1860

aaaataggat ttggaacctt attgtgataa atatttatat atgatgtatg tttgtctccc     1920

ctctccaaag taaggaaccc agctgggcgt ggtggctcac tcctgtaatc ccagcatttt     1980

gggaggccga ggtgggtgga ccgcttgagt ccacgagttt aagaccagcc tgggcaacat     2040

ggtgaagccc catctctac                                                  2059


<210> 4188
<211> 996
<212> DNA
<213> Homo sapiens

<400> 4188
aggctggtct atttgacagc tgtgacccca gacaactttc tgtctcccga agcctgagtt       60

tttttcacta gaagaaggcg gaataataat aataactaca agtctaggaa aacccagaag      120

agaaactctt tattgttcat aaggctatca cagatctttc tctccaagaa actagtgctg      180

atgaaatgac attcagagaa gggcatcagt gggagaagat tcctctgagt ggcagtaacc      240

aggaaataag aagacagaag gagaggatta ctgagcagcc tctcaaagag gaagaagatg      300

aggacaggaa gaacaaaggt caccaggcag ctgaaattga atggctggga tttcgaaaac      360

ctagccaagc tgacatgtta cattctaaac atgatgagga gcagaaggtt tgggatgaag      420

aaattgatga tgatgatgat gataattgca ataatgatga agatgaagtt cgagtgatag      480

aatttaagaa aaaacatgaa gaggtttctc aatttaaaga ggaaggtgat gcaagtgagg      540

actccccact gagcagtgcc agttcccaag ctgtgacacc tgatgagcag ccaaccttag      600

ggaagaagag tgatatctcc agaaatgctt attccagata caatacaata tcctatcgga      660

aaatcagaaa gggaaatacc aagcaaagaa ttgatgaatt cgagtctatg atgcatttat      720

aaactaactg gaactgagaa attctcatgc ccactaaagg aaaagctaat tctattgccc      780

cagggtgcat atttctatgc cttatttgag ttatcacttg gagggaggtg gaagttgact      840

ctctttttca ctgtagaata atgtggaaat aaccctagat aaaaattcag tctgataacc      900

tcaaatcaaa aagctttaaa taaattcttg ggcatttatc ttttaaaact tcactaatat      960

agcattgtgt gataagcact aagcagtcag tcccct                                996


<210> 4189
<211> 549
<212> DNA
<213> Homo sapiens

<400> 4189
attgtgtgct gggctgagcc tcccttcaca tggtcacatc cccattttaa tccaatactc       60

cctttcccta ccccttcccc agtcctgcct ctttctgtgg cacttattgc tggtttccct      120

gagctcctgt ttccactttg tgttttttgt ggggcccagg aagctaaagc tgtgtgtatt      180

tgtggatcag acaagtgcag caagttaata tcattggctt ctgaagggga gagtgaggtg      240

atggctgcgt ttaagttgga tttccttcca gaaatgatgg tggatcattg ctctttgaat      300

tccagtcccg tctcaaagaa aatgaacggc accctggacc acccagacca accagatctt      360

gatgctatca agatgtttgt gggccaggtt ccaaggacct ggtctgaaaa ggacttgcgg      420

gaactcttcg aacagtatgg tgctgtgtat gaaatcaacg tcctaaggga taggagccaa      480

aacccgcctc agagcaaagg gtgctgtttt gttacatttt acacccgtaa agctgcatta      540

gaagctcag                                                              549


<210> 4190
<211> 2256
<212> DNA
<213> Homo sapiens

<400> 4190
aggcgagctg acaaaagggc ggcgcgcgtc tgaaccgcca ttggggccca cagctccctt       60

aggactagct ctggatcctc ccggcgggcc ccagtgcaga gagcccacgg ccatccagtg      120

cctacaatgg ggacctcaat ggacttctgg tcccagaccc gctctgctca ggtgatagta      180

cctcagcaaa caagactggt cttcggacca tgccacccat taacctgcaa gagaagcagg      240

tcatctgtct ctcaggagat gatagctcca cctgcattgg gattttggcc aaggaggtgg      300

agattgtggc tagcagtgac tctagcattt caagcaaggc ccggggaagc aacaaggtga      360

aaattcagcc tgtcgccaag tatgactggg aacagaagta ctactatggc aacctgattg      420

ctgtgtctaa ctccttcttg gcctatgcca ttcgggctgc caacaatggc tctgccatgg      480

tgcgggtgat cagcgtcagc acttcggagc ggaccttgct caagggcttc acaggcagtg      540

tggctgatct ggctttcgcg cacctcaact ctccacagct ggcctgcctg gatgaggcag      600

gcaacctgtt cgtgtggcgc ttggctctgg ttaatggcaa aattcaagaa gagatcttgg      660

tccatattcg gcagccagag ggcacgccac tgaaccactt tcgcaggatc atctggtgcc      720

ccttcatccc tgaggagagc gaagactgct gtgaggagag cagcccaaca gtggccctgc      780

tgcatgaaga ccgggctgag gtgtgggacc tggacatgct ccgctccagc cacagtacct      840

ggcctgtgga tgttagccag atcaagcagg gcttcattgt ggtaaaaggt catagcacgt      900

gcctcagtga aggagccctc tctcctgatg ggactgtgct ggctactgcg agccacgatg      960

gctatgtcaa gttctggcag atctacattg aggggcaaga tgagccaagg tgtctgcacg     1020

agtggaaacc tcatgatggg cggcccctct cctgcctcct gttctgtgac aaccataaga     1080

aacaagaccc tgatgtccct ttctggaggt tccttattac tggtgctgac cagaaccgag     1140

agttaaagat gtggtgtaca gtatcctgga cctgcctgca gactattcgc ttctccccag     1200

atatcttcag ctcagtgagt gtgcccccta gcctcaaggt ttgcttggac ctctcagcag     1260

aatacctgat tctcagcgat gtgcaacgga aggtcctcta tgtgatggag ctgctgcaaa     1320

accaggagga gggccacgcc tgcttcagct ccatctcgga gttcctgctc acccaccctg     1380

tgctgagctt tggtatccag gttgtgagtc gctgccggct acggcacact gaggtgctgc     1440

ctgccgaaga ggaaaatgac agcctgggtg ctgatggtac ccatggagcc ggtgccatgg     1500

agtctgcggc cggtgtgctc atcaagctct tttgtgtgca tactaaggca ctgcaagatg     1560

tgcagatccg cttccagcca cagctgaacc ctgatgtggt ggccccactg cccacccaca     1620

ctgcccacga ggacttcaca tttggagagt ctcggcccga actgggctct gagggcctgg     1680

ggtcagccgc tcacggctcc cagcctgacc tccgacgaat cgtggagctg cctgcacctg     1740

ccgacttcct cagtctgagc agtgagacca agcccaagtt gatgacacct gacgccttca     1800

tgacacctag cgcctccttg cagcagatca ctgcctctcc cagcagcagc agcagcggta     1860

gcagcagcag cagcagcagt agcagcagct cccttacagc tgtgtctgcc atgagcagca     1920

cctcagctgt ggacccctcc ttgaccaggc cacctgagga gctgaccttg agccccaagc     1980

tgcagctgga tggcagcctg acaatgagca gcagtggcag ccttcaggca agcccgcgtg     2040

gcctcctgcc tggcctgctc ccagccccag ctgacaaact gactcccaag gggccgggcc     2100

aggtgtgtga ctgggtgtgt gtgtgaagtg tggggagcag gtgggcagca gcagggaagg     2160

tgggtggtgg gctcctccca gccccctgct gctgatcctg ctctacccga catggtccgt     2220

gtttccctga ggtcatttca ccctcctgtg tttcct                               2256


<210> 4191
<211> 1322
<212> DNA
<213> Homo sapiens

<400> 4191
gttctcctcc gtcctctctc ggttcccctt gattcctgcg gggtccaggg acccggacag       60

cttggggacg tccgcagagc ctgggtggct ttttctcaag tatattttcc agtctgtttg      120

gaactcggga aatgagaatt ttaattttgg gattagatgg agcaggaaaa accacaattt      180

tgtacagatt acaagtggga gaagttgtta ctactatacc taccattgga tttaatgtag      240

agacggtgac gtacaaaaac cttaaattcc aagtctggga tttaggagga cagacaagta      300

tcaggccata ctggagatgt tactattcaa acacagatgc agtcatttat gtagtagaca      360

gttgtgaccg agaccgaatt ggcatttcca aatcagagtt agttgccatg ttggaggaag      420

aagagctgag aaaagccatt ttagtggtgt ttgcaaataa acaggacatg gaacaggcca      480

tgacttcctc agagatggca aattcacttg ggttacctgc cttgaaggac cgaaaatggc      540

agatattcaa aacgtcagca accaaaggca ccggccttga tgaggcaatg gaatggttag      600

ttgaaacatt aaaaagcaga cagtaattca gtccattctt ctcccctgaa atgaagacta      660

catcacctct ctccctttgg aaacagtcaa gtgtacttca cactactaga tgttaaaact      720

atatgattat tggcatatac tgactgactg caatatttgt agtaaatagg gaaaataagt      780

atttagttgg agggataatt tgatcgaatc acctgaatgt tctatgtaat gtaaaatatt      840

cttttcttgc tttcttgtgt taaggtatat attctatttg tatggaattc ttattcaaat      900

acagttctat taaagagtat actcctattg gatgaaaaaa acctattttt gaatagtagt      960

tgcagcttgt ttgtataaat actaaaaaat atcttaacag atttttttcc ccttaaaatg     1020

aattatcttt ccaaagatta gactcagtat gagagtaggt gaggaacata gtttgtgtaa     1080

tataatcttt atttgcttac ctgaccactt tttattaagc tgttttgttt aaaagctttt     1140

ggttataggc atgaatattg ttttgatggt taacttcact gacttatctg taagtgtcat     1200

tttatagtac tttacagttg tcaaaaaaaa tcttacatat attgatctag ttgatcggta     1260

gaggaagctt gtgaagtagg taggacaggt tatgatgtct tcactgtatg gacgtgaacc     1320

ca                                                                    1322


<210> 4192
<211> 2553
<212> DNA
<213> Homo sapiens

<400> 4192
accgaaggtg aggctggtgg gtcccgcggg cgcggagaag gcgggtgacg gtgtgaccct       60

ctttagctct catggattgg gagctgggaa aggaatgaga agacagaagt cagagacaag      120

aagaggctaa catgactgat accactataa tttagtgaac tgcctctttt ctaaagagga      180

ctccaaagga aggactggtc atctctttca tatctcaaaa ccatggctca gggatcagtg      240

tctttcaatg atgtgactgt ggacttcact caggaggagt ggcagcacct ggatcatgct      300

cagaagactc tatatatgga tgtgatgttg gaaaactatt gccacctcat ctctgtgggg      360

tgtcacatga ccaaacctga tgtgatcctc aagttggaac gaggagaaga gccatggaca      420

tcatttgcag gtcatacctg cttggaagaa aactggaaag ctgaagactt tttagtgaaa      480

ttcaaggaac accaagagaa gtattctaga tcagttgtaa gcatcaacca caaaaaactg      540

gtgaaggaga agagtaaaat atatgaaaag acatttactc taggcaaaaa ccctgtgaat      600

tcaaaaaatc tacctcctga atatgatact catggaagga ttttgaaaaa tgtttcagaa      660

ttaatcatca gtaatctaaa tcctgcaaga aagagactta gtgagtataa tggatatggg      720

aaatcactcc tgagtactaa acaagagact actcatcctg aagtcaaatc ccataatcaa      780

agtgccagag ctttcagtca taatgaagtt cttatgcagt atcagaaaac ggaaactcca      840

gcacagtcat ttggatataa tgactgtgag aaatcattcc ttcaaagggg aggcctgatt      900

acacatagta gaccttacaa aggagaaaac ccatctgtat ataataaaaa aagaagagca      960

accaatattg aaaaaaaaca tacatgcaat gaatgtggga aatctttctg caggaaatca     1020

gtattgattc tgcatcaggg aattcactca gaagaaaaac cctatcaatg tcatcaatgt     1080

ggaaatgcat ttagaaggaa atcatatctc attgatcatc agagaactca cacaggagag     1140

aaaccctttg tttgcaatga atgtggtaag tccttccgcc tcaagacagc cctcactgat     1200

catcagagaa cacacacagg ggagaaatcg tatgaatgtc tgcaatgtag gaatgccttc     1260

agattgaagt cacacctcat tcgtcatcag agaactcaca cgggagagaa accatatgag     1320

tgtaatgact gtgggaagtc cttccgccag aagacaacac tctctctaca tcagagaatc     1380

catacaggtg agaaacccta catttgtaaa gaatgtggga agtcctttca ccagaaggca     1440

aatcttactg tacatcagag aactcataca ggggaaaagc cctatatttg taatgaatgt     1500

gggaaatcct tctcccagaa gacaaccctt gctcttcatg agaaaactca taatgaggag     1560

aaaccctata tttgtagtga atgtggaaag tccttccgcc agaagacaac ccttgtagca     1620

catcagagaa cacatacagg ggagaaatct tatgaatgtc ctcactgtgg gaaggccttt     1680

agaatgaagt catacctcat tgatcatcac cgaactcaca caggagagaa accatatgaa     1740

tgtaatgaat gtggtaaatc attcagtcaa aagacaaatc tcaatctaca tcagagaatt     1800

catacagggg agaaacccta tgtttgtaat gaatgtggga agtcctttcg ccagaaagca     1860

accctcactg tacatcagaa aatacatacc ggccagaaat cctatgaatg tcctcagtgt     1920

gggaaagcct ttagcaggaa gtcatatctc attcatcatc aaagaactca tacgggagag     1980

aaaccatata aatgtagtga atgtggaaag tgcttccgcc agaagacaaa tcttattgta     2040

catcagagaa ctcacacagg tgagaaaccc tatgtttgta atgagtgtgg taagtctttc     2100

agttataaga gaaacctcat tgtccatcaa agaactcaca agggagaaaa cattgaaatg     2160

caataaatga tgtggtttct tatatgaatt ctttacaagc tgttgtaaac atttagtttt     2220

aaaaagaaaa gcatgctgaa acatgttaat gtaattttaa atcacaagtc taataattat     2280

taaagtacca tacggaataa ctgtctactg tttactagca tataaaataa gtatgatcat     2340

tattattgaa ctctatcagc tatgaagcta aattttaaag tcaactgctc ttcctactga     2400

ctcaaatagt ttatttttta aaaatactta tataatacat gcagagacaa gatacacaat     2460

gattataagt attaatctcc ataagagaaa atatttatga actatatttc tcattgcact     2520

ctgtaataaa aagcagttag ttgttactta cct                                  2553


<210> 4193
<211> 4332
<212> DNA
<213> Homo sapiens

<400> 4193
aacagccgcc tccagccaag agagagaaaa aaactataag aattcgggat ccaaaccagg       60

gaggtaaaga cataacagag gagattatgt ctggaggtgg cagcagaaat cctactccac      120

ccataggaag acccacgtcc acacctactc ctcctcagag gagaagccaa aaccagatcc      180

agtgttaaag tctccttccc cagtccttag gctagtcctc agtggagaga agaaagaaca      240

agaaggccag acatctgaaa ctactgcaat agtatccata gcagagcttc ctctgcctcc      300

atcacctacc actgtttctt ctgttgctcg aagtacaatt gcagccccca cctcttctgc      360

tcttagtagc caaccaatat tcaccactgc tatagatgac agatgtgaac tctcatcccc      420

aagagaagac acaattccta tacccagcct cacatcttgc acagaaacat cagacccttt      480

accaacaaat gaaaatgatg atgatatatg caagaaaccc tgtagtgtag cacctaatga      540

tattccactg gtttctagta ctaacctaat taatgaaata aatggagtta gcgaaaaatt      600

atcagccacg gagagcattg tggaaatagt aaaacaggaa gtattgccat tgactcttga      660

attggagatt ctcgaaaatc ccccagaaga aatgaaactg gagtgtatcc cagctcccat      720

caccccttcc acagttcctt cctttcctcc aactcctcca actcctccag cttctcctcc      780

tcacactcca gtcattgttc ctgctgctgc cactactgtt agttctccga gtgctgccat      840

cacagtccag agagtcctag aggaggacga gagcataaga acttgcctta gtgaagatgc      900

aaaagagatt cagaacaaaa tagaggtaga agcagatggg caaacagaag agattttgga      960

ttctcaaaac ttaaattcaa gaaggagccc tgtcccagct caaatagcta taactgtacc     1020

aaagacatgg aagaaaccaa aagatcggac ccgaaccact gaagagatgt tagaggcaga     1080

attggagctt aaagctgaag aggagctttc cattgacaaa gtacttgaat ctgaacaaga     1140

taaaatgagc caggggtttc atcctgaaag agacccctct gacctaaaaa aagtgaaagc     1200

tgtggaagaa aatggagaag aagctgagcc agtacgtaat ggtgctgaga gtgtttctga     1260

gggtgaagga atagatgcta attcaggctc cacagatagt tctggtgatg gggttacatt     1320

tccatttaaa ccagaatcct ggaagcctac tgatactgaa ggtaagaagc agtatgacag     1380

ggagtttctg ctggacttcc agttcatgcc tgcctgtata caaaaaccag agggcctgcc     1440

tcctatcagt gatgtggttc ttgacaagat caaccaaccc aaattgccaa tgcgaactct     1500

ggatcctcga attttgcctc gaggaccaga ctttacacca gcctttgctg attttggaag     1560

gcagacacct ggtggaagag gcgtaccttt gttgaatgtt gggtcacgaa gatctcaacc     1620

tggccaaaga agagaaccca gaaagatcat cacagtttct gtaaaagaag atgtacacct     1680

gaaaaaggca gaaaatgcct ggaagccaag ccaaaaacga gacagccaag ccgatgatcc     1740

cgaaaacatt aaaacccagg agctttttag aaaagttcga agtatcttaa ataaattgac     1800

accacagatg ttcaatcaac tgatgaagca agtgtcagga cttactgttg acacagagga     1860

gcggctgaaa ggagttattg acctggtctt tgagaaggct attgatgaac ccagtttctc     1920

tgtggcttac gcaaacatgt gtcgatgtct agtaacgctg aaagtaccca tggcagacaa     1980

gcctggtaac acagtgaatt tccggaagct gctactgaac cgttgccaga aggagtttga     2040

aaaagataaa gcagatgatg atgtctttga gaagaagcag aaagaacttg aggctgccag     2100

tgctccagag gagaggacaa ggcttcatga tgaactggaa gaagccaagg acaaagcccg     2160

gcggagatcc attggcaaca tcaagtttat tggagaactc tttaaactca aaatgctgac     2220

tgaagccatc atgcatgact gtgtggtgaa gctgctaaag aaccatgatg aagaatccct     2280

ggagtgcctg tgtcgcctgc tcaccaccat tggcaaagac ttggactttg aaaaagcaaa     2340

gccacgtatg gaccagtact ttaatcagat ggagaaaatt gtgaaagaaa gaaaaacctc     2400

atctaggatt cggttcatgc ttcaagatgt tatagaccta aggctgtgca attgggtatc     2460

tcgaagagca gatcaagggc ctaaaactat cgaacagatt cacaaagagg ctaaaataga     2520

agaacaagaa gagcaaagga aggtccagca actcatgacc aaagagaaga gaagaccagg     2580

tgtccagaga gtggacgaag gtgggtggaa cactgtacaa ggggccaaga acagtcgggt     2640

actggacccc tcaaaattcc taaaaatcac taagcctaca attgatgaaa aaattcagct     2700

ggtacctaaa gcacagctag gcagctgggg aaaaggcagc agtggtggag caaaggcaag     2760

tgagactgat gccttacggt caagtgcttc cagtttaaac agattctctg ccctgcaacc     2820

tccagcaccc tcagggtcca cgccatccac gcctgtagag tttgattccc gaaggacctt     2880

aactagtcgt ggaagtatgg gcagggagaa gaatgacaag ccccttccat ctgcaacagc     2940

tcggccaaat actttcatga ggggtggcag cagtaaagac ctgctagaca atcagtctca     3000

agaagagcag cggagagaga tgctggagac cgtgaagcag ctcacaggag gtgtggatgt     3060

ggagaggaac agcactgagg ctgagcgaaa taaaacaagg gagtcagcaa aaccagaaat     3120

ttcagcaatg tcagctcatg acaaggctgc attatcagaa gaggaactgg agaggaagtc     3180

gaaatctatc attgatgaat ttctacacat taatgatttt aaggaagcca tgcagtgtgt     3240

ggaagagctg aatgcccagg gcctactaca tgtttttgtg agagtgggag tggagtccac     3300

cctggaaagg agccagatca ccagggatca catgggccaa ttactctatc agctggtaca     3360

gtcagaaaaa ctcagcaaac aggacttttt caaaggtttt tcagaaactt tggaattggc     3420

agatgacatg gccattgata ttccccatat ttggttgtac cttgctgaac tggtgacccc     3480

catgttaaaa gaaggtggaa tctccatgag agaacttacc atagaattta gcaaaccttt     3540

acttcctgtt ggaagagctg gggtcttgct atctgaaata ttgcacctac tatgcaaaca     3600

aatgagccat aagaaagtgg gagccttatg gagggaggct gacctcagct ggaaggactt     3660

tttaccagaa ggagaagatg tacataattt tcttttggag cagaagttgg acttcataga     3720

gtctgacagt ccctgttcct ctgaagcact ttcaaagaaa gaactgtctg ccgaagagct     3780

gtataagcga ctcgagaaac tcattattga ggacaaagcg aatgatgaac agatctttga     3840

ctgggtagag gctaatctag acgaaatcca gatgagttca cctacattcc ttagagcttt     3900

aatgactgct gtttgtaaag cagctattat agccgactct tctaccttca gagtggacac     3960

tgctgttatc aagcagagag tgccgatctt actcaagtac ctagactcag atacagagaa     4020

ggaactgcaa gcactttatg cactacaagc atcgatagta aaacttgatc aacctgccaa     4080

tttgctgcgg atgttttttg attgtctata tgacgaggag gtgatctccg aggatgcctt     4140

ctacaaatgg gagagcagca aggaccctgc agagcagaat gggaagggcg tggctctgaa     4200

atctgtcacg gcattcttca cgtggctgcg ggaagcagaa gaggagtctg aggataacta     4260

aaacttcaaa tacacaaaat gaaacaaaag aaacaattta agtatttttt taaaaagttt     4320

cacgtcttcg cc                                                         4332


<210> 4194
<211> 1623
<212> DNA
<213> Homo sapiens

<400> 4194
gcatgatggg ggaggcggcc gtggccgcgg ggccttgtcc gttgcgcgag gacagcttca       60

cgcgcttctc gtcgcagagc aatgtgtacg ggctggcagg cggcgccggc gggcgcgggg      120

agctgctggc cgccaccctt aaaggcaagg tgctcggctt ccgctaccaa gacctccgac      180

agaaaatccg gccagtggcc aaggagctgc agttcaacta cattcccgtg gatgcggaga      240

ttgtctccat cgacactttc aacaagtcac cccccaagcg gggtctggtt gtggggatca      300

cgttcatcaa ggattcaggg gacaagggca gccccttcct gaacatttac tgcgactacg      360

agcccggctc tgagtacaac cttgactcta ttgcccagag ctgcctgaac ctggagctcc      420

agttcactcc gttccagctg tgccatgcgg agtgagtgtc ccctgcgcat cgacgcccac      480

tccactatgg tgggttggat ttggtctgca ggtcataact tggccaacct ctggtctaac      540

agggtccagg tcggggatca acttgagact gtgtttctct tgagtgggaa cgacccggcc      600

attcatctct acaaggagaa cgaggggctg catcagtttg aggaacagcc cgtggaaaac      660

ctcttcccag agctgacgaa cctgaccacg tcctctggct ggacgtccac aacttccccg      720

gcacgtcccg gcgcctctca gctctgggct gtcagagtgg ttatgtccgt gtcgcccacg      780

tggaccagcg gagtcgagag gttctgcaga tgtggtcggt cctgcaggac ggtcccatct      840

cccgagtgat tgtgttcagc ctctcggccg ccaaggagac caaggacagg ccactacaag      900

atgagtacag cgtgctcgtg gccagcatgt tggagccagc agtggtgtat cgggacctgc      960

tgaaccgggg tcttgaagac cagcttctcc tgcccggcag tgaccagttt gacagcgtcc     1020

tctgcagcct ggtcaccgat gtggatttgg atgggcggcc agaagtcctg gtggccacct     1080

atggacagga actgctgtgt tataagtacc ggggcccaga gtcggggctt cctgaggccc     1140

agcacgggtt ccatctgctg tggcagcgga gcttctccag tcccctgctg gccatggctc     1200

acgtggacct gaccggggat gggctgcagg agcttgccgt ggtctccctg aagggcgtgc     1260

acatcctgca gcacagcctg attcaggcct cagagctggt cttgacccgg cttcgacatc     1320

aagtggagca gaggagacgt cggctacagg ggttggagga cggggcaggt gcagggcctg     1380

ctgagaatgc agcctcttaa gcacccatgc acccactctt cccagacctg gggcgactca     1440

tggcgtgctc acctccagcc gctggtgggg ggtgtcctga aggacaggat gctctcccca     1500

gacctcccca gggtggtgaa gctgtgccct ggggccccag ctaacccact cctctctctg     1560

tacgtcaatg tccctatttg aaagcaggga tgatcccatt ccaccctgtc cactctggat     1620

gag                                                                   1623


<210> 4195
<211> 1702
<212> DNA
<213> Homo sapiens

<400> 4195
gataagatgg ttgattcaca gaacccaggc tggacgggac ttgtggcgag cagtccagca       60

cagcctcaca gtgcagagca tgagctttgg agcctgcccc caccctagct ttgtgacctt      120

aagtgagcta catagcttct catgtgtaaa ctactcatca taatggttct gacctcagtg      180

gtttgttgtg ttctaggaaa tgatgccagt gaatgcgtag tcccagcctc agcacagggg      240

agccaccttg aagctctcaa atatcactgt tgtgaataca gagagggaaa accaactgta      300

acgtgccacc caaataaagc tcattactag tcctgtccag caacgtgcct ctcctggccc      360

tagagttctt ggaaatagcc caggccaaag agaaggcctt tctccccatg gtcagccaca      420

cgttccacat gcgcacagag gagtctgatg cctcacagga gggcgatgac ctacccaagt      480

cctcagcaaa caccagccat cccaagcagg atgacagccc caagtcctca gaagaaacca      540

tccagcccaa ggagggtgac atccccaagg ccccagaaga aaccatccaa tccaagaagg      600

aggacctccc caagtcctca gaaaaagcca tccagcccaa agagagtaac atccccaagt      660

cctcagcaaa acccatccag cccaagctgg gcaatattcc caagacctca gtgaagccca      720

gccagcccaa ggagagtgat atccccaagt ccccagaaga agccatccag cccaaggagg      780

gtgacatccc caagtcccta gaggaagcca tccagcctaa ggagggtgac atccccaagt      840

ccccagaaga aaccatccag cccaagaagg gtgacatccc caagtcccca gaagaagcca      900

tccagcccaa ggagggtgac attcccaagt ctccaaaaca agccatccag cccaaggagg      960

gtgacattcc caagtcccta gaggaagcca tcccacccaa ggagattgac atccccaagt     1020

ccccagaaga aaccatccag cccaaggagg atgacagccc caagtcccta gaagaagcca     1080

ccccatccaa ggagggtgac atcctaaagc ctgaagaaga aacaatggag ttcccggagg     1140

gggacaaggt gaaagtgatc ctgagcaagg aggactttga ggcatcactg aaggaggccg     1200

gggagaggct ggtggctgtg gacttctcgg ccacgtggtg tgggccctgc aggaccatca     1260

gaccattctt ccatgccctg tctgtgaagc atgaggatgt ggtgttcctg gaggtggacg     1320

ctgacaactg tgaggaggtg gtgagagagt gcgccatcat gtgtgtccca acctttcagt     1380

tttataaaaa agaagaaaag gtggatgaac tttgcggcgc ccttaaggaa aaacttgaag     1440

cagtcattgc agaattaaag taaacatgta ttctgaaaac attgcagaca gtcaggtgtt     1500

tatagctttt gagttctctt ttattattta cacaaagtga tcaggtataa caaaagtgta     1560

tgtccaaatg gcactgcttg tacatgataa tattaactct acccttttca aaaaacagtc     1620

caagcattaa agtacattgc gactgtgttt ctgttagtgg gagagtataa aattagaaat     1680

tcccatggtg aagactgcta ag                                              1702


<210> 4196
<211> 1934
<212> DNA
<213> Homo sapiens

<400> 4196
gtgatctgct cttccaagcc ctgggccgca cctacactga cgaagaattt gatgaactat       60

gttttgaatt tggtctggag cttgatgaaa ttgtccctcc tgagatctgc catctcctgg      120

gaggtgactc agctttcttc actattgaaa caacatctga gaaggaaata ataagtaaag      180

aacaaggtaa tgtaaaggca gcaggagcct ctgatgttgt tctttacaaa attgacgtcc      240

ctgccaatag atatgatctc ctgtgtctgg aaggattggt tcgaggactt caggtcttca      300

aagaaaggat aaaggctcca gtgtataaac gggtaatgcc tgatggaaaa atccagaaat      360

tgattatcac agaagagaca gctaagatac gtccttttgc ggtagcagca gttctccgta      420

atataaagtt tactaaagat cgatatgaca gcttcattga acttcaggag aaattacatc      480

agaatatttg caggaaaaga gcactggttg ccattggtac ccatgatttg gacactttgt      540

cgggcccatt tacttatact gcaaagcgtc cttcagatat caaattcaag cctctaaata      600

agaccaagga gtatacagcc tgtgaactga tgaacatata caagactgac aatcacctga      660

aacattattt acatatcatt gaaaacaaac ccctgtatcc agttatctat gatagcaatg      720

gtgtcgtcct ttcaatgcct cccatcatca atggggatca ttccagaata acagtaaata      780

ctagaaatat ttttattgaa tgcacgggaa ctgactttac taaggcaaaa atagttcttg      840

atattattgt caccatgttc agtgaatatt gtgagaatca atttacggtc gaagctgctg      900

aagtggtttt tcctaatgga aaatcacata cctttccaga attagcttac cgaaaggaga      960

tggtgagagc tgacctaatt aacaaaaaag ttggaatcag agaaactcca gaaaatcttg     1020

ccaaacttct gaccaggatg tatttaaaat cagaagtcat aggtgatggg aatcagattg     1080

agattgaaat ccctccaacc agagctgaca ttatccatgc atgtgatatt gtagaagatg     1140

cagctattgc ttatggatat aacaacattc agatgactct cccgaaaact tacaccatag     1200

ctaatcaatt tcctcttaat aagctcactg aacttctccg acatgacatg gcagccgctg     1260

gcttcactga agcacttacc tttgccctgt gctcccaaga agatattgct gataaactag     1320

gtgtggatat ctctgcaaca aaggcagtcc acataagtaa tcctaaaaca gctgaatttc     1380

aggtggcacg cactaccctt cttcctggcc tcctgaagac catagcagca aatcgtaaga     1440

tgccccttcc actgaaactg tttgaaatct ctgacattgt aataaaagat tctaatacag     1500

atgtaggtgc aaaaaactac agacatctct gtgctgttta ttacaacaag aatcctgggt     1560

ttgagatcat tcatgggctg ctggacagaa ttatgcagtt gctcgatgtg cctcctggtg     1620

aagacaaggg gggatatgtg atcaaagcat cagaagggcc tgctttcttc cccgggcgat     1680

gtgcagagat ctttgccagg ggtcaaagcg tcgggaagct tggggtcctt catcctgacg     1740

ttatcaccaa atttgagctg accatgccct gctcctccct agaaatcaat gttggaccct     1800

ttttgtgaag attggtctct gtggtgtgat tctcttccca ggtgtccctt tctcctcccc     1860

tagtgtcctt aagtcctcct ccacagggaa catctatttg ggctttgatg tttaataaag     1920

tagaaagcac tgtc                                                       1934


<210> 4197
<211> 1973
<212> DNA
<213> Homo sapiens

<400> 4197
cggggccgcg gcagagccgc tcccgaggcc ccggcgcggc gcgagggcgc ggggcgcggc       60

gtccacaggc gccgaggctg cccccgccgc cccgcccgcg aagatggcgg cggaactcta      120

cgctcccgcc agcgccgcgg ccgcggacct agccaacagc aacgccggcg ccgccgtggg      180

caggaaggcc gggccgcgca gcccgcccag cgcccccgcg ccagcgccgc cgccgcccgc      240

gcccgcgccg cccacactcg gcaacaacca ccaggagagc cccggctggc ggtgctgccg      300

ccccacgctg cgcgagagga acgcgctcat gttcaacaac gagctcatgg ccgacgtgca      360

cttcgtcgtg gggcccccgg gggcgaccag gacggtgccc gcccacaagt acgtcttggc      420

tgtcggcagc tccgtcttct atgccatgtt ctacggagac ctggcggaag tcaaatctga      480

aattcacatt ccagacgtgg agcccgcagc ctttctgatc ctcttaaagt acatgtacag      540

tgatgagatc gatctggaag ccgacacggt gctggccact ctgtacgctg ctaagaagta      600

catcgtccca gcattggcaa aagcctgtgt caactttctg gagacaagtt tggaagccaa      660

gaacgcctgc gtcctgctgt cccagagccg gctgtttgag gagcccgagc tgacgcagcg      720

ctgctgggag gtcattgacg cacaggccga gatggcccta cggtccgaag gcttctgtga      780

gatagaccgg cagacgctgg agatcattgt cactcgggag gccctcaaca ccaaagaggc      840

ggtggtcttc gaggccgtcc tgaactgggc cgaggcggag tgcaagaggc aggggctgcc      900

aatcacccca cgaaacaaga ggcatgttct ggggcgagcc ctctatctgg tccgaattcc      960

aaccatgacc ctagaggagt ttgccaacgg cgctgcccag tcagacatcc tgactctgga     1020

ggagacccac agcatcttcc tgtggtacac ggccaccaac aagccccgcc tggactttcc     1080

cctgaccaag aggaagggcc tcgccccgca gaggtgccac cgattccagt cttctgccta     1140

ccgcagcaac cagtggcggt accgcgggcg ctgcgacagc atccagtttg cagtggacag     1200

aagggtattt attgcagggc tgggcctgta tggctccagc tctgggaagg ctgagtacag     1260

cgtgaagatt gagctcaagc ggctcggggt ggttctggct cagaacttga ccaagttcat     1320

gtcagacgga tccagtaaca ccttcccggt ctggtttgaa cacccggtcc aggttgaaca     1380

agacaccttc tacacggcca gtgccgtcct ggacggcagc gaactcagct actttgggca     1440

ggaggggatg acggaagtgc agtgtggaaa ggtggccttc cagttccagt gctcctcgga     1500

cagcaccaac gggactgggg tccagggtgg gcagatccct gagctcattt tctatgcctg     1560

aggtgcccgg ggaggctgca gcaggtcagc gagtgagtgg aggggaagtc aagatgctaa     1620

ctgcttcttg acaccatgaa aggctgctct taactttgtc tctctttgac atgtagtcag     1680

ctgaagcttg actgtgtaga gacattttcc acacagccag aacccaggga ttggagtctt     1740

aggcatctct ggtacagtgg ggtgcacgtc tcaggtggag gaagatttac ggctcaagac     1800

aggccccaga tcccctccca gtggcaccca tgccacctgc tttgaggggt tggatcttcc     1860

tgctaccctc ttggattcta agtggttcca agcttaactt gagaccttcc cttcaaatct     1920

aaaattggca aaaagtcact taaaatagtg gacttctgta ataaaggttg cct            1973


<210> 4198
<211> 583
<212> DNA
<213> Homo sapiens

<400> 4198
gaccccgaaa tggcgctgct ggccgaacac ttgctgaagc cgctgcccgc ggacaagcag       60

atcgagaccg ggcccttcct cgaggcggtg tcccacctgc cgcccttctt cgattgcctt      120

gggtccccag tgtttactcc catcaaggca gacataagcg gcaacatcac gatgaggaag      180

ctgagactca gaggggttga aggactcgct taaggtcaca agcaaaaaat caaagctgtg      240

tacgacacca acccagccaa gttccggacc ctgcagaaca tcctggaggt ggagaaagaa      300

atgtatggag cagagtggcc caaagtaggg gccacactgg cgctgatgtg gctgaaaaga      360

ggcctccgct tcatccaggt cttcctccag agcatctgcg acggggagcg ggacgagaac      420

caccccaacc tcatccgtgt caacgccacc aaggcctacg agatggccct caagaagtac      480

catggctgga tcgtgcagaa gatcttccag gcagcactgt acgcagcacc ctataagtct      540

gacttcctga aagcgctctc caaggggcag aatgttacgg agg                        583


<210> 4199
<211> 3286
<212> DNA
<213> Homo sapiens

<400> 4199
atttgtgaaa gaattcggtc aacagtggat gaaaaagaac aaaaacaact tcttatggat       60

ttggatgtag taatgcggag tagtgattgc ccatacattg ttcagtttta tggtgcactc      120

ttcagagagg gtgactgttg gatctgtatg gaactcatgt ctacctcgtt tgataagttt      180

tacaaatatg tatatagtgt attagatgat gttattccag aagaaatttt aggcaaaatc      240

actttagcaa ctgtgaaagc actaaaccac ttaaaagaaa acttgaaaat tattcacaga      300

gatatcaaac cttccaatat tcttctggac agaagtggaa atattaagct ctgtgacttc      360

ggcatcagtg gacagcttgt ggactctatt gccaagacaa gagatgctgg ctgtaggcca      420

tacatggcac ctgaaagaat agacccaagc gcatcacgac aaggatatga tgtccgctct      480

gatgtctgga gtttggggat cacattgtat gagttggcca caggccgatt tccttatcca      540

aagtggaata gtgtatttga tcaactaaca caagtcgtga aaggagatcc tccgcagctg      600

agtaattctg aggaaaggga attctccccg agtttcatca actttgtcaa cttgtgcctt      660

acgaaggatg aatccaaaag gccaaagtat aaagagcttc tgaaacatcc ctttattttg      720

atgtatgaag aacgtgccgt tgaggtcgca tgctatgttt gtaaaatcct ggatcaaatg      780

ccagctactc ccagctctcc catgtatgtc gattgatatc gctgctacat cagactctag      840

aaaaaagggc tgagaggaag caagacgtaa agaattttca tcccgtatca cagtgttttt      900

attgctcgcc cagacaccat gtgcaataag attggtgttc gtttccatca tgtctgtata      960

ctcctgtcac ctagaacgtg catccttgta atacctgatt gatcacacag tgttagtgct     1020

ggtcagagag acctcatcct gctcttttgt gatgaacata ttcatgaaat gtggaagtca     1080

gtacgatcaa gttgttgact gtgattagat cacatcttaa attcatttct agactcaaaa     1140

cctggagatg cagctactgg aatggtgttt tgtcagactt ccaaatcctg gaaggacaca     1200

gtgatgaatg tactatgtct gaacatagaa actcgggctt gagtgagaag agcttgcaca     1260

gccaacgaga cacattgcct tctggagctg ggagacaaag gaggaattta ctttcttcac     1320

caagtgcaat agattactga tgtgatattc tgttgcttta cagttacagt tgatgtttgg     1380

ggatcgatgt gctcagccaa atttcctgtt tgaaatatca tgttaaatta gaatgaattt     1440

atctttacca aaaaccatgt tgcgttcaaa gaggtgaaca ttaaaatata gagacaggac     1500

agaatgtgtt cttttctcct ttaccagtcc tatttttcaa tgggaagact caggagtctg     1560

ccacttgtca aagaaggtgc tgatcctaag aatttttcat tctcagaatt cggtgtgctg     1620

ccaacttgat gttccacctg ccacaaacca ccaggactga aagaagaaaa cagtacagaa     1680

ggcaaagttt acagatgttt ttaattctag tattttatct ggaacaactt gtagcagcta     1740

tatatttccc cttggtccca agcctgatac tttagccatc ataactcact aacagggaga     1800

agtagctagt agcaatgtgc cttgattgat tagataaaga tttctagtag gcagcaaaag     1860

accaaatctc agttgtttgc ttcttgccat cactggtcca ggtcttcagt ttccgaatct     1920

ctttcccttc ccctgtggtc tattgtcgct atgtgacttg cgcttaatcc aatattttgc     1980

cttttttcta tatcaaaaaa cctttacagt tagcagggat gttccttacc aaggattttt     2040

agccccaaat ctctcatatt cgctagtgtt taaaaggcta agaatagtgg ggcccagccg     2100

atgtggtagg tgataaagag gcatcttttc tagagacaca ttggaccaga tgaggatccg     2160

aaacggcagc ctttacgttc atcacctgct agaacctctc gtagtccatc accatttctt     2220

ggcattggaa ttctactgga aaaaaataca aaaagcaaaa caaaaccctc agcactgtta     2280

caagaggcca tttaagtatc ttgtgcttct tcacttaccc attagccagg ttctcattag     2340

gttttgcttg ggcctccctg gcactgaacc ttaggctttg tatgacagtg aagcagcact     2400

gtgagtggtt caagcacact ggaatataaa acagtcatgg cctgagatgc aggtgatgcc     2460

attacagaac caaatcgtgg cacgtattgc tgtgtctcct ctcagagtga cagtcataaa     2520

tactgtcaaa caataaaggg agaatggtgc tgtttaaagt cacatccctg taaattgcag     2580

aattcaaaag tgattatctc tttgatctac ttgcctcatt tccctatctt ctcccccacg     2640

gtatcctaaa ctttagactt cccactgttc tgaaaggaga cattgctcta tgtctgcctt     2700

cgaccacagc aagccatcat cctccattgc tcccggggac tcaagaggaa tctgtttctc     2760

tgctgtcaac ttcccatctg gctcagcata gggtcacttt gccattatgc aaatggagat     2820

aaaagcaatt ctgactgtcc aggagctaat ctgaccgttc tattgtgtgg atgaccacat     2880

aagaaggcaa ttttagtgta ttaatcatag attattataa actataaact taagggcaag     2940

gagtttatta caatgtatct ttattaaaac aaaagggtgt atagtgttca caaactgtga     3000

aaatagtgta agaactgtac attgtgagct ctggttattt ttctcttgta ccatagaaaa     3060

atgtataaaa attatcaaaa agctaatgtg cagggatatt gccttatttg tctgtaaaaa     3120

atggagctca gtaacataac tgcttcttgg agctttggaa tattttatcc tgtattcttg     3180

tttgaattcc tcctctattt aagatatata catggaatcg aagtgtttat gtaatagttc     3240

tatccttttg cctgcaggtc agttgtaata aatctaggat gtgatg                    3286


<210> 4200
<211> 528
<212> DNA
<213> Homo sapiens

<400> 4200
aagaaacaag atcttgagct gagcaagaac atcccagcat cttcattgac tttaaaagta       60

tattctggag tcttccgtgg ttcactattc cagtactaca gagtcatttt tatctgtgtc      120

tttccattgc agattcctta tattacatgg caggaggggg gtaaactgag ggatagtgaa      180

gacaacaata aattaatcaa gagctttcct catatctcag aacctatcct ctgtaagaat      240

gtcagaaaag gttgactggt tacaaagcca aaatggagta tgcaaagttg atgtctattc      300

tcctggagac aaccaagccc aggactggaa aatggacacc tccacggatc ctgtcagagt      360

gctcagctgg ctccgcagag acctggagaa gagtacagca gagttccaag atgttcggtt      420

caaacccgga gaatcatttg gtggggaaac gtccaactca ggagacccac acaaaggttt      480

ctctgtagac tattacaaca ccaccaccaa gggcactcca gaaagatt                   528


<210> 4201
<211> 886
<212> DNA
<213> Homo sapiens

<400> 4201
aacagggctt cgtcttcttt gcagagccat gggcagcagg aagaaggaaa ttgccctgca       60

ggtcaacatc agcacccaag agctttggga ggaaatgctc agttccaaag gactaactgt      120

tgttgatgtc tatcaaggct ggtgtggccc ctgcaaacct gtggtgagcc tcttccagaa      180

gatgaggatc gaggtcggcc tggaccttct gcactttgca ttagcagagg cagatcgtct      240

tgatgtcctc gaaaagtaca gagggaagtg cgagccaacc tttctgtttt atgcaattaa      300

agatgaggct ctttctgatg aagatgaatg tgtttcccat ggaaagaata atggtgaaga      360

tgaggacatg gtttcatcag agaggacctg taccttggcc atcattaaac cagatgcagt      420

ggcccatgga aagactgatg agattatcat gaagattcag gaagctgggt ttgaaattct      480

aacaaatgaa gagagaacca tgacagaggc agaagtgcga cttttctacc aacacaaagc      540

tggagaggag gcatttgaga agctggtaca tcacatgtgc agtggaccaa gccacctcct      600

gatcctcacc aggactgagg gcttcgagga cgtggtcact acctggcgaa ccgtcatggg      660

cccccgtgac cccaatgtgg ccaggaggga gcagccagaa agtctccgag ctcagtacgg      720

cacagaaatg cccttcaatg ccgtccatgg aagccgggac agagaagatg ctgacagaga      780

actggcattg ctcttcccca gtttgaaatt ttcagacaaa gatacagaag cccctcaggg      840

tgagtccagt acacagccaa ggttgaagat cactgaccta gactaa                     886


<210> 4202
<211> 2610
<212> DNA
<213> Homo sapiens

<400> 4202
gaacactcat cagtgcgcag gcgcccatct tagttggtct tctagtccgg taaacagagg       60

gcctgccccc gacagcttct gcttccgggt cacgccttga cagcggcttt caacccccac      120

ctcagcccag caattcgttt ggagcatgtg aacaccttga gccttgatga gttccagtat      180

gtggtatatt atgcagagca ttcagagcaa atactctctc tccgagcgct taatccgaac      240

aattgctgcc atccgttcct tcccacatga taatgtagag gacctcatca gagggggagc      300

agatgtgaac tgcactcatg gcacactgaa gcccttgcac tgtgcctgta tggtgtcaga      360

tgctgactgt gtggagttac ttctggaaaa aggagccgag gtgaatgccc tggatgggta      420

taaccgaaca gccctccact atgcagcaga gaaagatgag gcttgtgtgg aggtcctatt      480

ggagtatggt gcaaacccca atgctttgga tggcaacaga gataccccac ttcactgggc      540

agcctttaag aacaatgctg agtgtgtgcg ggctctccta gagagcgggg cctctgtcaa      600

tgccctggat tacaacaatg atacaccgct cagctgggct gccatgaagg gaaatcttga      660

gagtgtcagc atccttctgg attatggcgc agaggtcaga gtcatcaacc taataggcca      720

gacacccatc tcccgcctgg tggctctgct agtcagggga cttggaacag agaaagagga      780

ctcttgcttt gagctcctcc acagagctgt tggacacttt gaattgagga aaaatggcac      840

catgccacga gaggtggcca gagacccgca gctatgtgaa aaactgactg ttctgtgctc      900

agctccagga actctaaaaa cactcgctcg ctatgccgtg cgccgtagcc tgggactcca      960

gtatctcccc gatgcagtga agggccttcc actgccagct tctttgaagg aatacctgtt     1020

acttttagaa tagccggaga agatgtttgc accatcgtgc aggcagctct gggtgaggtt     1080

gtccctgcag tactccttgt cacagaaaac agaaaaacag ttgttcctgt tgtgtggttt     1140

atagatttcg aagcaacatg tcacaacaat aacctccata gcacctcccc ttcccaaacc     1200

aaacaaccca acaaaaaaaa tccctcactt ttgttttctg tttattgctt acctggcttt     1260

ttatattgca ttttgcaaaa gaagaggtct ccctcaatcc tcccctttag ggaaggagtc     1320

aacagtgtaa ctaaatttct ctaggaagat ggaaagtact taaataatgt gtgtgtggtt     1380

ttcctttggg gacgtggtta acggtccaga agaatccctt ctagaaagca ttttaggcca     1440

gccatggtgg ctcacgtctg taatcccagg actttgggag gctgaggcag gtggatcacc     1500

tgaggtcagg agttcgagcc cagcctgacc aatatgatga aaccccgtct ctactaaaaa     1560

tacaaaaatt agctgggcat ggtggcatgc gcctgtaatc ccagctactc aggaggctga     1620

gacagaagaa tcgcttgaac ctgtgaggca gaggttgcag tgagccaaga tcgcgccatt     1680

gcactccagc ctggacaaca agagcaaaac tgtctcaaaa aaaaaaaaaa aaaaaaaaaa     1740

ccattttaat tgatctgtga aaaaacttaa gaaaatcaca atttcagcta acagcaattg     1800

tgtcccaaag atgaagatac tataacctca aatggtgcag atccagaact gggctggatg     1860

acatccctac tgtgccatgt cctggggcat ttggaaggga ctggacctct ttcccctcat     1920

caaaggaaac agcagtcttt gcctctttct gttggttgtg cccaagggct acagtagctc     1980

tgaaataaca agagctctgt aataacagta ataaatagct ctgaaataac agtcctaaga     2040

actcctaaag tcctgagaac ttttcttgta atgcagcttt ttctcttcct gagaaacagt     2100

gtgttctaat gggattccca ggcagttcct acacctacgg tgtgtgttcc agcagggagg     2160

agttatgggc tgggctgcct tttcccatgg gtcttcattc ccaatggaaa gttcactctg     2220

cttagtttgg aattattttt ctttcagttg ttctggaacc tttgcttttt attgatttat     2280

acaatacaat tggtgggagg gtggacttgg gatgggagtg ggaaaagcat gtaagagctc     2340

cttttgtgat ggtccatcta cccaaaagag atctgcttta gtgaacgata ctctttcatt     2400

tttctaaatt agatcaagtt gttattgatt ttagatgact tgtatgcaaa tttgaaaaac     2460

tttttttttt aaagctgatt gggaactaca aacaatgaat ggaatctact gacacagcta     2520

attggaaaac agatgtcttc ttctgtccta ttgatgctgg tgtttaaaaa acatcactta     2580

aaaaaaaaga ataaatagtt ctaaaagcaa                                      2610


<210> 4203
<211> 2403
<212> DNA
<213> Homo sapiens

<400> 4203
aaaaggggcg gtggcggcgg cggcggcggc ggcggcggcg gcgacggcga gaaagagctt       60

gccggggggc gagcaggaca ggacgaagcc ggagtgtagg cggcagagga ttcgctccca      120

gagcagctgc ggccaggtcg gaaagaggcc ggggcggctg ggtatatgaa tgacctaaag      180

gtacaaataa agacggagag agaacagtgc caactgggag cagggcaaga atgccaattc      240

ctcctccccc gccaccccca cctggtcctc ctccacctcc cacatttcat caggcaaaca      300

cagagcagcc caagctgagt agagatgagc agcggggtcg aggcgccctc ttacaggaca      360

tttgcaaagg gaccaagctg aagaaggtga ccaacattaa tgatcggagt gctcccatcc      420

tcgagactcc tccaccccca ccacctgtga tccgaaatgg tgccagggat gctccccctc      480

ccccaccacc ataccgaatg catgggtcag aacccccgag ccgaggaaag cccccacctc      540

caccctcaag gacgccagct gggccacccc ctcctcctcc accgcccctg aggaatggcc      600

acagagattc tatcaccact gtccggtctt tcttggatga ttttgagtca aagtattcct      660

tccatccagt agaagacttt cctgctccag aagaatataa acactttcag aggatatatc      720

ccagcaaaac aaaccgagct gcccgtggag ccccacctct gccacccatt ctcaggtgaa      780

gcctggcttg gtcccgttcc tcaggaaaag gatggacctt ctcttcttct cagatggtcc      840

cttccattcc cctgaaacct gcatgagagc tcctaacatg tttctccaat gcaatcaagc      900

cctagactcc aaatgtcctc ccagctcacc tccatctatg catctcatct ctggatttgg      960

tgatcagact ctatattgac agtaggatct caaaccctgc atccatcctt cctccagcaa     1020

gccctgctag ccacatgagg aacaagtttc cgtgtcttct gccttcctct tggggaaagg     1080

tgccttgttg tgatgaatta actcactgtt agggcagggt ggagaatggt actccttcct     1140

tctcctgtcc actgtggggg aagcttggca ggtatattat atttcatcat ttaggaggct     1200

ggcatgacca ggacttatgg gtgggagggg agcattttta gtgaagcaag aaaggagttt     1260

gccaagaagt gatctgtttt aaaggtcata tttggagaaa gggcaaggaa ttgggtctgc     1320

tttatttttg ggggtatttt gtttttgttc tcacctgctg cccccccacc ccaccacccc     1380

agggataaat tggatataaa cactaaatac taatcagttg aacttaacat ttaataaaaa     1440

gaaagggtga aataaactga agaccatttt agaactagtc agttctctgc agcaaaggga     1500

acaggagcca tttgaaccct ctgggacccc tcaccccact gcttcagggt gctaggctga     1560

gggatgtttt tcctccccct taccgcccat gcccttgaaa gaaaagtcac tttttgtgga     1620

gggcatcatt cattcctgat tcacaaaccc caaaaacctc tggtgggaga taggaagata     1680

gggcgtgggc ctgggcctta acctcaatct tgtgtctgcc tcagtctttt ctgactggcc     1740

ctgaagttgt cagtggctct ttctgtcctt cagcccctgg aaggtgctcc aggataacaa     1800

agaagggcag gttgaagccc ctcatggaag gagctggctt tgtggggctg caaaggactt     1860

ttaagtcctg cctgtactga agttcacagc ccacctgact gagcagactc ttcctgttcc     1920

tttctctacc acccttgcct tcccaggact gcacggttta acacagcaga gtacagaagg     1980

gtgaagaagt gagcagaggc ttatgaagat attcagatac tcttctatgc caggaagcac     2040

aaagactttg ttgagatttg cctcagttca gtagatcttc cttggcagcc agccataggt     2100

tgtttctttg tcttccgggt cctaaagagc acagagaaaa tggaggtccc cagtctaggt     2160

aggaagctga ttggatgagg acttcttttt ttccgacagc aggatggggc tcttgggctc     2220

cacacaccag atgctttggt tttctacaac tgttgctatg tgtagagggt gctcagagcg     2280

tggcatgaga gcaaggagac catggctact ctttgaaatg gatggggaaa attagcttaa     2340

aaatttaatc acgagattgc gccactgcac tccagcctgg gcgacagagc cagactccgt     2400

ctc                                                                   2403


<210> 4204
<211> 1032
<212> DNA
<213> Homo sapiens

<400> 4204
ggttgctagt ggagaagcaa ccttggccat ggaccagccg gctggcctgc aggtggacta       60

cgtcttccgg ggtgtggagc atgccgtgcg ggtgatggtt tctgggcagg tgctggagct      120

ggaggtggag gaccggatga cggctgacca gtggcggggc gagttcgatg ctggcttcat      180

tgaagatttg actcacaaga cagggaactt caaacagttc aacatcttct gtcatatgct      240

ggagtcagcc ctcactcaga gtagtgagtc agtcaccctg gacctgctga cctacacaga      300

cctggagtcc ctgcggaacc gcaagatggg gggccgccca ggctccttgg cccccaggtc      360

ggcccagctc aactccaagc gctacctgat cctcatctac tccgtggagt ttgacaggat      420

tcactacccg ctgcccctcc cgtaccaggg caagccagac cccgtggttc tgcagggcat      480

catccggtca ctgaaggagg aactgggccg cctgcaaggg ctggatggcc agaacactcg      540

ggacacccgg gagaatgaga tctggcatct gcgggagcag cagcagcagc ggaaccgctt      600

aggcagtggg ggaagcgggg acggtccgtc cgtctcctgg tctcgccaga cccagccccc      660

tgctgccttg actggccgag gggacgcccc taaccgctcc cgaaaccgca gctcctcagt      720

ggacagtttc cgcagccgct gctcgtctgc cagctcctgc agcgatttgg aggatttctc      780

tgagtcgctc tccagagggg gtcaccgccg ccgtgggaag cctcccagcc caacgccctg      840

gagtgggtcc aatatgaagt ctccccccgt ggaacgcagc caccatcaga aatctctggc      900

caactccggg ggctgggtcc ccatcaaaga gtacagctcg gagcaccagg cggctgacat      960

ggccgaaata gacgcacgcc tgaaggcctt gcaggagtac atgaaccgac tggacatgcg     1020

gtcataacgt gg                                                         1032


<210> 4205
<211> 899
<212> DNA
<213> Homo sapiens

<400> 4205
gctgctgagc ggttttgcag actaccatct tccctgcaac tctgaaggat ggacttaacc       60

accaccatgt cgagcaaaag aacaaagacc aagaccaaga agcgccctca gcgtgcaaca      120

tccaatgtgt ttgctatgtt tgaccagtca cagattcagg agttcaaaga ggccttcaac      180

atgattgatc agaacagaga tggtttcatc gacaaggaag atttgcatga tatgcttgct      240

tcattgggga agaatccaac tgatgagtat ctagatgcca tgatgaatga ggctccaggc      300

cccatcaatt tcaccatgtt cctcaccatg tttggtgaga agttaaatgg cacagatcct      360

gaagatgtca tcagaaatgc ctttgcttgc tttgatgaag aagcaactgg caccatacag      420

gaagattact tgagagagct gctgacaacc atgggggatc ggtttacaga tgaggaagtg      480

gatgagctgt acagagaagc acctattgat aaaaagggga atttcaatta catcgagttc      540

acacgcatcc tgaaacatgg agccaaagac aaagatgact gaaataactt caaattccag      600

ccaaacgttc cttgttgcca ctttgggtat tctgagattt tctcttgcat gcccttagct      660

ttacagcttt tgcatttcct gttgtattta ttctcagcca ttttgggcat atgtatcttt      720

ataatcagac tggaaacggg actttctatt aatatcattt tcagaataaa aaataggata      780

atttaaccta ccagcccttc tcccccaata actgtggtct atacagagtc aatatatttt      840

ttcagagaaa gttattcgct cgattttttc tgaatcataa ttaaacttta tgataaaat       899


<210> 4206
<211> 2791
<212> DNA
<213> Homo sapiens

<400> 4206
actgcggagc ccagagggcc agctgcgcgg cctgtggacg cgggatggca ggggcgagct       60

ccacgccctg tccccgtcta agctaccacc tttacttcca ccaggctggg aaccagggct      120

tccttggttg tggtcagcaa tgagtctgga tgacaatttg tcgggcacga gcggtatgga      180

agtggacgac cgcgtgtcgg cgctggagca gcggctgcag ttacaggaag acgagctggc      240

ggtcctaaag gcggcgctgg cggatgctct gcgtcgcctg cgggcatgcg aagaacaggg      300

agcggcgcta cgcgcgcggg gcacccccaa gggccgggcg cctccgcgct taggcaccac      360

tgcctcggtg tgtcagctct tgaaaggcct tcccaccagg acgcccctta atggctcggg      420

acccccgcgg cgcgtgggtg gctatgccac gtccccatcc tctcccaaga aggaggcgac      480

ctccgggcgc agcagtgtcc gccgctactt gtcaccagag cgcctcgcct cggtgcgccg      540

tgaggacccc cgcagccgga ccacatcctc cagcagcaac tgtagcgcca aaaaggaagg      600

caaaaccaaa gaagttatct tcagtgtgga ggatggctcc gtgaaaatgt tcctgagggg      660

ccgccctgtg cccatgatga tcccagacga gctggcaccc acctacagcc tggacacacg      720

ctcggagctg ccttcttgcc ggctcaagct ggagtgggtc tatggctacc gtggccgaga      780

ctgccgggcc aacctttatt tgctgcccac cggggagata gtgtactttg tggcctccgt      840

agccgtgcta tacagcgtgg aggagcagag gcagcgacac tacctgggac acaacgatga      900

catcaaatgc ttggccatcc acccagatat ggtcaccatc gccacgggac aggtggcggg      960

aaccactaag gaagggaagc cgctgccgcc ccacgtgcgc atctgggact cagtttccct     1020

ctccacctta cacgtgctgg gcttgggggt gtttgacaga gccgtgtgct gtgtgggctt     1080

ctccaaatct aatggaggca acctgctgtg tgcagtggat gaatccaatg atcacatgct     1140

ctcggtgtgg gactgggcca aggagaccaa ggtggtggat gtcaagtgct ccaatgaggc     1200

tgtattggtg gccaccttcc accccacgga ccccactgtg cttatcacct gcgggaaatc     1260

tcacatctac ttctggacct tggagggggg cagcttgagc aagcggcaag gcctctttga     1320

gaaacatgag aaaccgaagt atgtgctgtg tgtgaccttt ttggaaggtg gcgacgtggt     1380

cacgggggac tctgggggga acctctatgt ttggggcaaa ggtgggaacc gtatcacaca     1440

ggcggtgctg ggcgcccacg acggcggcgt gtttgggctc tgcgccctgc gggacgggac     1500

gctggtgtct ggagggggcc gtgatcggcg ggtggtcctc tggggttctg actacagcaa     1560

gctgcaggaa gtggaggtcc ctgaggactt tggccctgtg cgcaccgtgg cagagggcca     1620

cggagacaca ctgtacgtgg ggaccacccg caattccatc ctgcagggct ccgtgcacac     1680

aggcttctca ctgctggtcc agggccatgt ggaagagctg tggggcctgg ccacacaccc     1740

cagtcgggcc cagtttgtga cctgcgggca ggataagctg gtgcatctat ggagctcaga     1800

ttcccaccag cccctgtgga gcaggatcat cgaggaccct gcccgctcag ccggcttcca     1860

ccccagtggc tctgtcctgg ctgtgggtac agtgactggc agatggctgc tgctggacac     1920

ggagacccat gacctggtgg ctatccacac agacggcaat gaacagatct cagtggtcag     1980

cttctcccca gacggggcgt acctggccgt gggctcccac gacaacttgg tgtacgtgta     2040

cacggtggac cagggcggcc gcaaggtcag ccgcctgggc aagtgctcgg gccattccag     2100

ttttatcacc cacctggatt gggcccagga cagcagctgc tttgtcacca actccgggga     2160

ctatgagatt ctgtactggg acccggctac ctgtaagcag atcaccagtg cggatgctgt     2220

gaggaacatg gaatgggcca cagctacttg tgtcctaggg tttggggtgt ttgggatctg     2280

gtctgagggg gcggacggca ctgatatcaa cgctgtggcc cgctctcatg atgggaagtt     2340

gctggcttca gctgatgact ttggcaaagt tcacctgttt agctacccct gctgtcagcc     2400

tcgagccctc agccacaagt acggtggaca cagcagccat gtgacaaatg tggccttctt     2460

gtgggatgac agcatggccc tgaccacagg gggcaaggac accagtgtgc tacagtggcg     2520

ggtggtctga tgcggccagg gaagagtcag gtgtcagggc aggaattcta ttttcgggag     2580

atgtctattg ccgagtagag taatatatac ccagagtatg tctatagcag agggggttat     2640

gggggcggga gggtagactg acatacagaa gtctctattt atccgggtgg gaagagggag     2700

tcacatcgct ttggggatcc attggtgttt ggtttggggt gttttttaag ttttttcttt     2760

tatatcatcc agaaataaag acacgtacac t                                    2791


<210> 4207
<211> 1296
<212> DNA
<213> Homo sapiens

<400> 4207
gtgtgttgcg cgactggcct tgagggagag ctggggcctg ctcccggaga gatacggcta       60

tgtcgatcga aatcgaatct tcggagcata cccagatgga agtagcaaag aaaagagaag      120

agcagcaatt gcccaggcct tagctggcga agtcagtgtg gtgcctccat ctcgtctcat      180

ggcattgctg ggacaggcac tgaagtggca gcagcatcag ggattgcttc ctcctggtat      240

gaccatagat ttgtttcgag gcaaggcagc tgtcaaagat gtggaagaag aaaagtttcc      300

tacacaactg agcaggcata ttaagtttgg tcagaaatca catgtggagt gtgctcgatt      360

ttctccagat ggtcagtatt tggtcactgg gtctgttgat ggattcattg aagtatggaa      420

ctttactact ggaaaaatca gaaaggatct taagtaccag gcccaagata actttatgat      480

gatggatgat gctgtcctct gcatgtgttt cagcagagat acagaaatgt tagcaactgg      540

ggcccaagat ggaaaaatca aggtgtggaa gattcagagt ggacaatgtt taaggagatt      600

tgagagggca cacagtaagg gtgtcacctg tctaagcttt tctaaggata gcagtcagat      660

ccttagtgct tcttttgacc agacaattag aattcatggt ttaaaatctg ggaaaaccct      720

gaaggaattt cgtggccatt cctcctttgt taacgaagca acatttacac aagatggaca      780

ttacattatt agtgcatcct ctgatggcac tgtaaagatc tggaatatga agaccacaga      840

atgttcaaat acctttaaat ccctgggcag caccgcaggg acagatatta ccgtcaacag      900

tgtgattcta cttcctaaaa accctgagca ctttgtggtg tgcaacagat caaacacggt      960

ggtcatcatg aacatgcagg ggcagattgt cagaagcttc agttctggta aaagagaagg     1020

tggggacttt gtttgctgtg ccctctctcc ccgtggtgaa tggatctact gtgtagggga     1080

ggactttgtg ctctactgtt tcagtacagt cactggcaaa ctggagagaa ctttgacagt     1140

gcacgagaag gatgtgattg gtattgcaca tcaccctcat cagaacctga ttgctaccta     1200

cagtgaagat ggactcctaa agctctggaa accataattc aacttttctt tttaaatcag     1260

ctcgaaagca tgtacttaaa tgaagcatat tcatgt                               1296


<210> 4208
<211> 2526
<212> DNA
<213> Homo sapiens

<400> 4208
acagacggcg ggtgaacatg gcgtcctcga cttggtctga gacgtgatag gcctgccttc       60

tggttgaaga tgtggcgagt gaaaaaactg agcctcagcc tgtcgccttc gccccagacg      120

ggaaaaccat ctatgagaac tcctctccgt gaacttaccc tgcagcccgg tgccctcacc      180

aactctggaa aaagatcccc cgcttgctcc tcgctgaccc catcactgtg caagctgggg      240

ctgcaggaag gcagcaacaa ctcatctcca gtggattttg taaataacaa gaggacagac      300

ttatcttcag aacatttcag tcattcctca aagtggctag aaacttgtca gcatgaatca      360

gatgagcagc ctctagatcc aattccccaa attagctcta ctcctaaaac gtctgaggaa      420

gcagtagacc cactgggcaa ttatatggtt aaaaccatcg tccttgtacc atctccactg      480

gggcagcaac aagacatgat atttgaggcc cgtttagata ccatggcaga gacaaacagc      540

atatctttaa atggaccttt gagaacagac gatctggtga gagaggaggt ggcaccctgc      600

atgggagaca ggttttcaga agttgctgct gtatctgaga aacctatctt tcaggaatct      660

ccgtcccatc tcttagagga gtctccacca aatccctgtt ctgaacaact acattgctcc      720

aaggaaagcc tgagcagtag aactgaggct gtgcgtgagg acttagtacc ttctgaaagt      780

aacgccttct tgccttcctc tgttctctgg ctttcccctt caactgcctt ggcagcagat      840

ttccgtgtca atcatgtgga cccagaggag gaaattgtag agcatggagc tatggaggaa      900

agagaaatga ggtttcccac acatcctaag gagtctgaaa cagaagatca agcacttgtc      960

tcaagtgtgg aagatattct gtccacatgc ctgacaccaa atctagtaga aatggaatcc     1020

caagaagctc caggcccagc agtagaagat gttggtagga ttcttggctc tgatacagag     1080

tcttggatgt ccccactggc ctggctggaa aaaggtgtaa atacctccgt catgctggaa     1140

aatctccgcc aaagcttatc ccttccctcg atgcttcggg atgctgcaat tggcactacc     1200

cctttctcta cttgctcggt ggggacttgg tttactcctt cagcaccaca ggaaaagagt     1260

acaaacacat cccagacagg cctggttggc accaagcaca gtacttctga gacagagcag     1320

ctcctgtgtg gccggcctcc agatctgact gccttgtctc gacatgactt ggaagataac     1380

ctgctgagct ctcttgtcat tctggaggtt ctctcccgcc agcttcggga ctggaagagc     1440

cagctggctg tccctcaccc agaaacccag gacagtagca cacagactga cacatctcac     1500

agtgggataa ctaataaact tcagcatctt aaggagagcc atgagatggg acaggcccta     1560

cagcaggcca gaaatgtcat gcaatcatgg gtgcttatct ctaaagagct gatatccttg     1620

cttcacctat ccctgttgca tttagaagaa gataagacta ctgtgagtca ggagtctcgg     1680

cgtgcagaaa cattggtctg ttgctgtttt gatttgctga agaaattgag ggcaaagctc     1740

cagagcctca aagcagaaag ggaggaggca aggcacagag aggaaatggc tctcagaggc     1800

aaggatgcgg cagagatagt gttggaggct ttctgtgcac acgccagcca gcgcatcagc     1860

cagctggaac aggacctagc atccatgcgg gaattcagag gccttctgaa ggatgcccag     1920

acccaactgg tagggcttca tgccaagcaa gaagagctgg ttcagcagac agtgagtctt     1980

acttctacct tgcaacaaga ctggaggtcc atgcaactgg attatacaac atggacagct     2040

ttgctgagtc ggtcccgaca actcacagag aaactcacag tcaagagcca gcaagccctg     2100

caggaacgtg atgtggcaat tgaggaaaag caggaggttt ctagggtgct ggaacaagtc     2160

tctgcccagt tagaggagtg caaaggccaa acagaacaac tggagttgga aaacagtcgt     2220

ctagcaacag atctccgggc tcagttgcag attctggcca acatggacag ccagctaaaa     2280

gagctacaga gtcagcatac ccattgtgcc caggacctgg ctatgaagga tgagttactc     2340

tgccagctta cccagagcaa tgaggagcag gctgctcaat ggcaaaagga agagatggca     2400

ctaaaacaca tgcaggcaga actgcagcag caacaagctg tcctggccaa agaggtgcgg     2460

gacctgaaag agaccttgga gtttgcagac caggagaatc aggttgctca cctggagctg     2520

gcctgg                                                                2526


<210> 4209
<211> 1065
<212> DNA
<213> Homo sapiens

<400> 4209
caagggaggc gcgtcggtct gggaagtcgc gcgcactcgc tgctcctggg accgacgttt       60

aactcttgcc aagtctcgtc gcagccgccg cggctggcgg gccttgggct tcccctgaag      120

catgagccct ctcgcccgca gccaccctca ccgcgtggcc cgcggacagt gcgcgccggg      180

gtcccgggtg cacagcctca ggataccccg tgcccgcagc tcgggcgccc gcggcaggcg      240

atcagtgggt gaccgcggct gcgagggact ttgtcatccg tcctccagga tctggggaga      300

aagagcccca tcccttctct ctctgccacc atttcggaca ccccgcaggg actcgttttg      360

ggattcgcac tgacttcaag gaaggacgcg aacccttctc tgaccccagc tcgggcggcc      420

acctgtcttt gccgcggtga cccttctctc atgaccctgc ggtgccttga gccctccggg      480

aatggcgggg aagggacgcg gagccagtgg gggaccgcgg ggtcggcgga ggagccatcc      540

ccgcaggcgg cgcgtctggc gaaggccctg cgggagctcg gtcagacagg atggtactgg      600

ggaagtatga ctgttaatga agccaaagag aaattaaaag aggcaccaga aggaactttc      660

ttgattagag atagctcgca ttcagactac ctactaacaa tatctgttaa aacatcagct      720

ggaccaacta atcttcgaat cgaataccaa gacggaaaat tcagattgga ctctatcata      780

tgtgtcaaat ccaagcttaa acaatttgac agtgtggttc atctgatcga ctactatgtt      840

cagatgtgca aggataagcg gacaggtcca gaagcccccc ggaacggcac tgttcacctt      900

tatctgacca aaccgctcta cacgtcagca ccatctctgc agcatctctg taggctcacc      960

attaacaaat gtaccggtgc catctgggga ctgcctttac caacaagact aaaagattac     1020

ttggaagaat ataaattcca ggtataaatg tttctctttt tttaa                     1065


<210> 4210
<211> 1202
<212> DNA
<213> Homo sapiens

<400> 4210
gtttccggtt cgcctccgga gccatggcgg cggcactgaa gtgtctactg acattaggaa       60

gatggtgccc cggccttgga gtggctcccc aggcccgggt gagtgcctac attccctgct      120

gtcggagaga ctctggatct gcagagacat ctccgcgcag aggaggagcg ctcctggcag      180

cccccgccct agcgattgcc agcaactttc ctttctgcca ggaaatcaac ctacctttct      240

ctgcctgcag gcgctcgccg ccttagtacc cggagtgacc caggtagata acaagtccgg      300

tttcctgcag aagaggcctc atcgccagca ccctggcatc ctaaagctgc cgcacgtgcg      360

gctgccacag gcactggcta acggtgccca gttattgcta cttgggagcg ctgggcccac      420

tatggagaat caggtgcaaa cactgaccag ttatctctgg agcagacatt tgcctgtaga      480

gccagaggag ttgcaaagac gggctaggca tcttgagaaa aaattcctgg aaaacccagg      540

tcctgacttc cagtccttgt tctcaccaca gacttatctc agacagagga gaaacttcgt      600

ggagcagtgc tacacgcact acgtaaaact acctaccatt ggcaagaact gagctacact      660

gagggactga gcctggtgta tatggcagca agactggatg gtggctttgc agcagtctcc      720

agagcattcc atgagatccg ggctcgaaat ccagcatttc agccacaaac tttgatggac      780

tttggctcag gtactggttc tgtcacctgg tgagtaactt tcttcagccc tatcttggtc      840

aattttagct ctagaaagcc atacttacac cactccaaaa ttaacagact ggaaaaccag      900

agggagaata ggcaagttgg gaatctataa tgtttcttcc atcagattag gcaaggcaga      960

agaaggtata tggattgggg ccagaactta aaagaaatgt caagtaaaaa aaggcgcatg     1020

tgtagaaaaa ttaaaaagaa aaggaattat caatcaaagt tgtttttgcc tacaaatagt     1080

attttgagtc tacctttttt ttttcttagg agttgtaaat aaaacaagaa aataacacta     1140

ttagttattt tattactaac tatacaacta ctttaacata acactctctt ttcccagggg     1200

tg                                                                    1202


<210> 4211
<211> 1882
<212> DNA
<213> Homo sapiens

<400> 4211
attcccggga ggggggagcg gcgttggagg ccaccgtttc cagcatcaac aacagcaact       60

tgtgattggc ggtgaccgga tattcagttg cacatcccca catcaatgca ctgccaatgg      120

attttctcat tcagcattta cctttggtat agaaagccat atcagtcagt ccaatataaa      180

tggtgccctc gtcccacccg ctgcattgat ttctatcatc cagaaaggtc tacagtatgt      240

agaagcagaa gttagtatta atgaggatgg taccttgttt gatggtcgac caatagagtc      300

tctgtccctg atagatgccg taatgcctga tgtagtacaa acaagacaac aagcttatag      360

agataagctt gcacagcaac aggcagcagc tgctgcagct gccgcagctg cagccagcca      420

acaaggatct gcaaaaaatg gagaaaacac agcaaatggg gaggagaatg gagcacatac      480

tatagcaaga atatggaatc ttagtgagaa cagcaccagt ggctctacac agttagtact      540

tagacattgt atacgagaag gagggcaaga tgttccaagc aacaaggatg tcacatctct      600

agattggaat agtgaaggta cacttctagc aactggttcc tatgatgggt ttgccagaat      660

atggactaaa gatggtaacc ttgctagcac cttagggcag cataaaggcc ctatatttgc      720

attaaaatgg aataagaaag gaaatttcat cctaagtgct ggagtagaca agactacaat      780

tatttgggac gcacatactg gtgaagccaa gcaacagttt ccttttcatt cagcaccagc      840

attggatgtt gattggcaga gcaacaacac ctttgcttct tgtagtacag atatgtgcat      900

tcatgtctgt aaattaggac aagacagacc tattaaaaca ttccaaggac atacgaatga      960

agtaaatgct atcaaatggg acccaactgg caatctcttg gcctcctgtt ctgacgacat     1020

gactttaaag atatggagta tgaaacaaga caattgtgtc catgatttgc aagcacataa     1080

taaagaaatt tatactatca aatggagtcc aacaggacca gggactaata atccaaatgc     1140

caaccttatg ttagcaagtg catcctttga ttctactgtt aggttatggg atgtagaccg     1200

agggatatgc atccatacct tgacaaaaca ccaagagcct gtgtacagtg tagctttcag     1260

tcctgatggc aggtatctgg caagtggttc ttttgacaaa tgtgtacaca tctggaacac     1320

gcagacaggt gctctagttc acagctatag gggaacaggt ggaatatttg aagtttgctg     1380

gaatgcagca ggagacaaag ttggagccag tgcatcagat ggttcagttt gtgtattaga     1440

ccttcggaaa tagcgctact agttggaagc catggaccga ctatgaatgt gtacatagcc     1500

aaaatgactg tccctgaccc atgtactgct atagtcccac ttgaaccatg gccagtccac     1560

tacagccaaa tctaaaagaa atatatacat acagtgtata taaacaaaat tgcaccctga     1620

agatgacaga gttttgtcac agcttgtgaa ttctgttcac caagtgctgg aatctaatct     1680

gctgtgcccc taaaatagca tttagaagtt ttggatatga aaaacagaag agagaaaaat     1740

atacattata aaagcagaac atacatgtac cagtttttgg atactaaatg acagccttgt     1800

ttctcccctt tgaatcagca gacaccatgg attatattct ttttttccct tcagtagtga     1860

gcagtttgta tgtacagaga aa                                              1882


<210> 4212
<211> 5677
<212> DNA
<213> Homo sapiens

<400> 4212
ggggcgcggg gcgcgggggc tgtagggagg gggaccagtg gcagagggac cttaggtgat       60

ccttagaaat aaaggctagc ttctgttcga ccttggagta gggcgaagag gtgtagacag      120

gcctggagaa gcgaggtaaa agcctgagta aaagcaagaa gttggagaat atgagataca      180

tctcatctct agtaaatact taaatgactt cccctcctcc cggagtcaag cacaattcgg      240

ggatgcaatg acggacgtag gtgaagacac tgcgggaact tacagacaaa actggtttgt      300

ggcctgtttg attcctgtca gaggtttgct gacccaagac agtatcgaaa atgcatatta      360

agtcaattat tctagaggga ttcaagtcct atgctcagag gaccgaagtc aatggttttg      420

accccctctt caatgctatc actggcttaa atggtagtgg gaaatccaac atattggact      480

ccatctgctt tttgctgggc atctccaacc tgtctcaggt tcgggcttct aatttacaag      540

atttagttta caaaaatggg caggctggta ttaccaaagc ctctgtgtca atcacttttg      600

ataattctga caaaaagcaa agtcctttag gatttgaggt tcatgatgaa atcacagtaa      660

caaggcaggt ggttattggt ggtagaaata aatatttaat caatggagtc aatgccaaca      720

acaccagagt acaggatctc ttctgttctg ttggccttaa tgttaacaac cctcactttc      780

tcatcatgca gggccgaatt acaaaagtat tgaatatgaa acctccagag attttatcca      840

tgatagaaga agcagctgga accaggatgt atgaatacaa aaaaatagct gcacagaaaa      900

ctatagaaaa aaaggaggct aagctgaaag aaattaagac gatacttgaa gaagagatta      960

ctccaaccat tcaaaaatta aaagaggaaa gatcgtccta cttggagtac caaaaagtaa     1020

tgagagaaat agaacatttg agtcgtttat atattgctta tcagtttttg ctggctgaag     1080

ataccaaagt acgctcagct gaggaattaa aagaaatgca agataaagtt ataaagcttc     1140

aggaagaatt gtctgagaat gataaaaaaa taaaagcact taatcatgaa atagaagaat     1200

tggaaaaaag aaaagataag gaaactggag gtatacttcg atctttagaa gatgctcttg     1260

cagaggctca gcgagttaat actaaatctc aaagcgcatt tgatctcaag aagaaaaatc     1320

tggcatgtga ggaaagcaaa cgcaaagagc tggaaaaaaa tatggttgag gactcaaaaa     1380

ctttagcagc aaaggaaaaa gagaaaataa agaggaaagc cttttggaaa agcgcaggca     1440

gctgtctcgt gatattggta gattgaaaga aacatatgaa gctctattag ccagatttcc     1500

caatcttcga tttgcataca aggatccaga gaagaactgg aatagaaatt gtgtgaaagg     1560

acttgtggct tctctgatta gtgtgaaaga cacttctgca accacagctt tagaattagt     1620

ggctggagaa cgactctaca atgttgtagt agacacagaa gttactggta aaaagctact     1680

agaaaggggg gaactgaaac gtcgatacac tataattcca ctcaataaaa tttcagccag     1740

atgtattgca ccagaaactc tgagagttgc tcagaatctt gttggccctg acaacgttca     1800

tgtggctctt tccttggttg aatataaacc agaacttcag aaagcaatgg agtttgtctt     1860

tggaacaaca tttgtttgtg acaatatgga taatgccaaa aaagtggcct ttgataagag     1920

gataatgact agaactgtaa ctctcggagg tgatgtgttt gatcctcatg ggacattgag     1980

tggaggtgct cgatcccagg cagcttccat tttaaccaag tttcaagaac tcaaagatgt     2040

tcaggatgaa ctgagaatca aagagaatga gctgcgggct ctagaagagg aattagcagg     2100

tcttaaaaac actgctgaaa agtatcgcca actaaaacag cagtgggaga tgaaaactga     2160

agaggcagat ttattacaaa ccaagctcca gcaaagctca tatcacaagc aacaagaaga     2220

attagatgcc cttaaaaaaa ccattgagga aagtgaggag actttgaaaa acactaaaga     2280

aatccaaaga aaagcagaag aaaaatatga agtattggaa aataaaatga aaaatgcaga     2340

agctgaaaga gagcgagaac tgaaagatgc tcagaaaaaa ctggattgtg ccaaaacaaa     2400

ggcagatgca tctagcaaga agatgaaaga aaaacaacag gaagttgaag ctatcactct     2460

ggaactggaa gagctcaaga gagagcatac atcttacaaa caacagcttg aagctgtaaa     2520

tgaagctatc aaatcctatg aaagtcagat tgaagtaatg gcagctgagg tggctaaaaa     2580

taaggagtca gtaaataaag ctcaagaaga ggtgaccaag caaaaagagg tgataacagc     2640

ccaagacact gtaattaaag ctaaatatgc agaagtggca aaacacaagg agcaaaacaa     2700

tgattctcag cttaaaatta aggaattaga ccacaacatc agcaaacata aacgggaggc     2760

tgaagatggt gctgcaaagg tatccaaaat gttgaaagat tatgactgga ttaatgcaga     2820

gagacacctc tttggccaac ccaatagtgc ctatgatttc aaaactaaca accctaaaga     2880

agctggtcag agacttcaga agttgcaaga aatgaaggag aaactaggaa gaaatgtcaa     2940

tatgagagct atgaatgtat tgacagaagc tgaagagcga tacaatgact tgatgaagaa     3000

gaagagaatt gtagaaaatg acaaatccaa aattcttaca actatagaag accttgacca     3060

gaagaaaaac caagccctaa atattgcatg gcaaaaggtg aacaaggact ttgggtctat     3120

tttttctact cttttgcctg gtgctaatgc tatgcttgca ccaccagagg gtcaaactgt     3180

tttggatggt ctggagttca aggttgcctt gggaaatacc tggaaagaaa acctaactga     3240

acttagtggt ggtcagaggt ctttagtggc cttgtcatta atactgtcca tgcttctctt     3300

caaacctgct ccaatttata tccttgatga ggtagatgca gccttggatc tttctcatac     3360

ccaaaacatt ggacagatgc tgcgtactca tttcacacat tctcagttca ttgtggtgtc     3420

actaaaagaa ggtatgttca acaatgcaaa cgttcttttc aaaaccaagt ttgtggatgg     3480

tgtttctaca gtagccagat ttactcaatg tcaaaatgga aagatttcaa aggaagcaaa     3540

atccaaggca aaaccaccca aaggagcaca tgtggaagtt taaactacaa agttatttct     3600

tcatcttgac ctgttttttt aaatgtaaac ttttaaggac ttgagataac taatttgttt     3660

atatacaaaa attaatgtta ctgtgttact taacccatgt tttctcttta tataatcact     3720

tatcgcttac aaatgagcat atattcctca tctcttaact agtctaatta tggtccaatt     3780

attgtggttg tgattttatg catatcatca aatgtttttt tcttatgcgg gtcttttata     3840

tattagggat cctgagatac ccgattctat atgtaaaagc taatatacaa aaaagcagat     3900

taaattacat gataaatgta gctgatcatc agtgtttaat tgatttaatt cctaaggcaa     3960

tattaatgtg ttttctaaag tcattcaggt aaggaagaat tataaatcag gtaactggac     4020

caacaaaggg aacacatata aagctattat gcatgcatgg agccgtttga ggctagtttt     4080

ttaaggccac aactccagac ccctgattta gactgagata ggaaacagat cttgaaagaa     4140

tccttatttt aatgatacat gaatatcatg ttcctatacg cttaataatt ggtctctacg     4200

ttttaatgat acatgaatat catgttccta tacgcttaat aattggtctc tacgacttta     4260

atgtttttgt ttttttaagc tgtgtaagta tttttaaatc aaagcttagg aggtgtgttg     4320

cgtggtacta tctgctgcaa atttatctga agtttgttaa tattttccaa gatttttgtc     4380

agccttttca taatccagtc attaacaacc tattggtaaa caagaatgta ggtgccagta     4440

gactaaacca aatttatttt tccctgagtc tgatatatat atgtataaat ataaataact     4500

caatccatct gttccaccaa aataactcaa aagttggatg attatttgtc ttccgctttc     4560

cagttcaaag ggatgaaatt cctttagaac ttgaaagatg acactagcga acaccatgag     4620

aatactgtct acagtttttg gtacgtcatc actagaacag tgaccccaaa ctgaatcatg     4680

aaaggtctga catgatgtaa tctgatcttc catgtgttat tttggcccca catctcttct     4740

tgatttttta gtcttatttc cttagtgtta ttatcatact tcccctgata tatggccgta     4800

cttcctggcc ctgggcttga catttcccac ccttcattct ccatacatat gagatgtcag     4860

aaaacatgca gtaattgata ttatgggaca cattggaaag gattgaatct ggaattagtt     4920

ctgtccactg tggaggggag aggaaataat gctgtaaatg ttgagttaca gaaagtccaa     4980

tgtcaaatat agtttttttg tttcctttca aatgtattac agactgtgcc aaaacagtta     5040

ccaattcaca ctgtcaatat taaagtatac catagtatac aaattagtca gtacttgctg     5100

ttaattttaa tatttctgat ttaacagtta gttattaagt ggtacttcat tgctgtttta     5160

gccaacgttt taaaaataat ttgggagttt gactattttg gcttacgtac tcatttcctt     5220

ttctctgcta aaaatgtttt gcttgtgtgc gttcctgatt tttgtcttgt ataatcttga     5280

tctttgaaaa ccctcaaaca tgtattaaat tgttgtaact ttttttcatt agagggaaga     5340

cattaagggg attggggaca tttgtttcac acatctgcag taatatgagt taactaatat     5400

ttaacaagct ctttctttac attagctgct gttctcattt gtatgtattg tcatatttaa     5460

tcctcagagt aacctagtga ggtaaatact gttgttgtca gcatggtgta atcgaggaat     5520

tgagtgagtt gagcagaaaa gttaggaaac ttgctcaggg tgataataca gttaggagtg     5580

tcagggccca tggacaaatc ttgtcagtct ccagaaccta agatatacta cgtcactgac     5640

agcttgaaca tttgtattta ttgtacagaa taaattt                              5677


<210> 4213
<211> 2539
<212> DNA
<213> Homo sapiens

<400> 4213
cacaagctcc aaagtggaat tggccggctg attctgaagg aagaaatgaa ggcccggtcg       60

agctcctatg cagatccctg gacccctccc cggagctcca ccagcagccg ggaagccctg      120

cacacagctg gctatgagat gtccctcaat ggctcccctc ggtcgcacta cctggctgac      180

agtgatcctc tcatctccaa atctgcctcc ctgcctgcct accgaagaaa tgggctgcac      240

aggacaccca gcgcagacct cttccactac gacagcatga acgcagtcaa ctggggcatg      300

cgagagtaca agatctaccc ttatgaactg ctgctggtga ctacaagagg aagaaaccga      360

ctgcccaagg atgtagacag gacccgttta gagcgccacc tgtcccagga agagttctac      420

caagtctttg gcatgaccat ctctgagttt gaccggctgg ccctctggaa gaggaatgaa      480

ctgaagaagc aagcccggct gttctaggca gaggctctat aaatatatat gcatttatat      540

aaagatatat gtaaaatctc tctactgaag ctcggtataa tcctctcttg tgtaatggga      600

cacactgcct gccatgagac ttgcttttct gtactgtcag gcaagcccac gtcatcgaga      660

tatttttatg ctccttactt tctcttttct aagtgctgtg ggatctggga agggatttga      720

ggggactctg tccttttatt ggggatcctt tttatactga aacatctgtc ctaacttgag      780

tgccccaagg tccaactctc tttcctaaag aaggtgcctg aagaagtctc tcttctctct      840

gcttcgtggc ccctttctta aatttctagg gctgatgctg accatgtggt ttccacacct      900

tattggcccc agaggggccc tcccatggga agatctgcag cagtctcccc aaatcagtga      960

gcacctttga gcgcccacga agaactttct caacaccccc aattaggagc tcagtgctct     1020

cttggggcaa tgcagttaaa agggtgagcc tcaaatctag tcattacacc agtcaacaga     1080

agtggacagg gcctaggcct ctcctcagct ccttaaccct cctccttctg ccctggattg     1140

taacctctcc cttgtccaaa tctaggattc ctggtaggaa aaggaaaagg cccttccctt     1200

ccctccacca cttccaactg gcccctttgc ctgacctgga cttggagaac cagaggaaaa     1260

gagagggagc ggaagtggga gatggagcag ggcacctgtt agaatcagag ctgcaggatt     1320

tcttgggacc ctcctctctc cctcactgct cccagcacct cctgaccctt ccctctttca     1380

aggagaagcc catgattgca gcttgtattc tttagcctta ttacaatcta tgtgcctgac     1440

aactcaacac accgcagggc taatgttccc accagagctc caactgaaca accagacaga     1500

caactctcat catcctccag agagaaaata ggccgtgtct caaagaaagg ttcttggtct     1560

atgcctctgg tctgtgggct ggcagggcaa ccataccata cccccgccag tcctcggctc     1620

ctgctgcaaa gttggccatg tttcacaggg aaacttttgg aagagtggct gcttatgaga     1680

ttccaaaatg aagtgttggc caacaccgct catggccatc ctggattttc ccagtggctt     1740

cccttcctgc tcgcctccct gaacagggga gaaagcttaa cctctcttct cctctccaaa     1800

cctttcacct tgaatgggta atgtttggtg ggggctgttc cttcttggag aagccttgag     1860

tcggaccatt ttgagatcat ggaggaagga tgaagaagtg aaaatgacaa taatgactct     1920

caagaggctg gcgatgtgac atggcaaatg tagaactgac ttaaattgaa caaaccctca     1980

ctgagcacct ctgatgttga gcacctgctg aatactgagc actgaatggg ggagggggag     2040

gggagcacgg ggtgagtcaa cctgggactc ggtctcaggg atatgcctac caatagcggg     2100

tatcgtaagg catgtaccca aacataacgg atgtaaggca gaaagtgatc ggagaaggaa     2160

tgagaaagtg tgcgtgatgt taatgaaaag tcatatgcag ctagagcaga cccaggaaag     2220

ctttctggaa gagattgcat ctgaggaaat tcaggaagga tctttgtaga ttggggggag     2280

attctaaatt gaaggggtga tggggtgagg ggccagaggg aagtctgctg tgttctcatg     2340

taggatgtca gccctccctg caacttctct ttttggccaa tgtcttttca ctttcctgac     2400

cctttagaat catccccagc cagacgcaat catggaagtt gccttattgt cactggttaa     2460

gaacttggcg agattgaagg gcttttgtta ttgttgttgg atatttttgt ttcccataaa     2520

agcacatcat ttcaaccct                                                  2539


<210> 4214
<211> 3498
<212> DNA
<213> Homo sapiens

<400> 4214
gtggagagcc ggccgacggg agccgcggcg gagcctgttg agctcgcgcg ggctgccggg       60

agtggtctct gaggcggcgg cggcggcggg gatcgtctcc ggcactgacg caccatgtcg      120

gtcagtgtcc atgagacccg caagtcgcgg agcagcacgg ggtccatgaa cgtcaccctc      180

ttccacaagg cctcccaccc ggactgtgtg ctggcccacc tcaacacgct tcgcaagcac      240

tgcatgttca ccgacgtcac actctgggcg ggcgaccgtg ccttcccctg tcaccgtgcc      300

gtgctggccg cctctagccg ctattttgag gccatgttca gccatggcct tcgggagagc      360

cgggatgaca ctgtcaactt ccaggacaac ctgcacccgg aggtgctgga gctgctgctg      420

gactttgcct actcctcacg catcgccatc aacgaggaga acgctgagtc actgctggag      480

gcaggcgaca tgctgcagtt ccacgatgtg cgggatgctg ccgccgagtt cctggagaag      540

aaccttttcc cctccaactg cctgggcatg atgctgctct cggacgccca ccagtgccgc      600

cggctgtatg agttctcctg gcgcatgtgc ctggtgcact ttgagacggt gaggcagagc      660

gaggacttca acagcctgtc caaggacaca ctgctggacc tcatctcgag tgatgagctg      720

gagaccgagg acgagcgggt ggtcttcgag gccatcctcc agtgggtgaa gcacgacctg      780

gagccacgga aggtccactt gcccgagctc ctccgcagcg tgcgtctggc cttgctgccg      840

tccgactgcc tgcaggaggc cgtctccagc gaggccctcc tcatggcaga cgagcgcacc      900

aagcttatca tggatgaggc cctgcgctgc aagaccagga tcctgcagaa tgatggcgtg      960

gtcaccagcc cctgtgcccg gccacgcaag gcgggccaca cgctactcat cctggggggc     1020

cagaccttca tgtgtgacaa gatctaccag gtggaccaca aggccaagga gatcatcccc     1080

aaggccgacc tgcccagccc ccggaaggag ttcagcgcct cagcgatcgg ctgcaaggtc     1140

tatgtgacgg ggggcagggg ctccgagaac ggggtctcca aggatgtctg ggtgtacgac     1200

accgtacatg aggaatggtc caaggcggcg cccatgctga ttgcccgctt tggccatggc     1260

tcagctgagc tggagaactg cctctatgtg gtggggggac acacatccct ggcaggggtc     1320

ttcccggcct cgccttctgt ctccctgaaa caagtggaga aatacgaccc tggggccaac     1380

aagtggatga tggtggcccc cttgcgggat ggcgtcagca atgccgcagt ggtgagtgcc     1440

aagctgaagc tctttgtttt cggaggaacc agcatccacc gggacatggt gtccaaggtc     1500

cagtgctatg acccctcgga gaacaggtgg acgatcaagg ccgagtgccc ccagccttgg     1560

cggtacacag ccgctgccgt cctgggcagc cagatcttca tcatgggagg tgacacggaa     1620

ttcacagccg cctcggccta ccgctttgac tgtgagacca accagtggac gcggattggg     1680

gacatgactg ccaagcgcat gtcctgccat gccctggctt ccggcaacaa gctctatgtg     1740

gtcgggggct actttgggac ccagaggtgt aagactctgg actgctatga ccccacttca     1800

gatacatgga actgcatcac cacagtgccc tactcactta tccccacggc ctttgtcagc     1860

acctggaagc acctgcccgc gtgaggagca cctgctgagc ccagccagac cgcggccttc     1920

agtgtcacag cgtggccttg cttgtctgcc acagcgggag ctaagccggc cctgggccag     1980

cactccgaga ggtggaaggg gccctgccag ctctggggag cagcagcctt gggctgttct     2040

gagctttagg caagagaaga gaagcatctc ttgcatccgt gcccctgggg gcctcttcag     2100

ctttgcagtg gtttgtggga agacatacct cccagagggg catggactgc caccaggact     2160

gaccctggcg tcggggagaa ggacacttgc agagccttga gatcacctgt ttggcaggtc     2220

ctggactggg gccgggcagg caggggcagg gaggcgcccc gggtgggctt tggggctgcg     2280

gcactgccac acatcctttc cctcctggcc tgccctgctg gggctctact gccatctata     2340

gatggtgtcc tgggcctggg aaactaggtt cccaggggtt gagaccagaa aggtgaccaa     2400

gacagatttt ttaaggtgca gaaactgcag gggggcctca gtgacatcca tgaggcctta     2460

ttagcaaagg acacccagac ctccaaggtt tgtgggcccc ttccacaaag ctgtaagtcc     2520

cagcccacct actcagggcc ttgctcagtg ctgtggcccg gtggggacac agttgctcgt     2580

ggccactcag tggagctggg cctgcagcag actcaaggct ccgagtgccc tgggggtcac     2640

ccctcccctc ccctcctcag agcccaccct gagaggcagc agtgaccccc atggcacaca     2700

cctgccaaca gcactggggg cttctcccca ggagaccacg ctgccctcca agaccaggag     2760

cagctgtgag ctggagacag cagagggacc ccagggtgtc ccctgcagat cccaccaggg     2820

ccgcatccat ctcagtgtgg aggacagtga cgggaccctc accatcctct tgcgttttgg     2880

cccccatttg ctccctgagc tccaagataa gaatggcccc gagagaactg ctgaacattt     2940

gttcattgct gtcacctcct gagtcactgg ggtccctcac cagcacctcc ctgacacctg     3000

ggctatggag aggttggcgc ctgtcagtga ccatcctaat gcctctcgct cactcccaag     3060

ccaccatttg agagggaggg gtgttggtgc cctgacaggg actgggcagg gtgtccaaac     3120

ttggggcttc ccaggcacct gcagtgtgaa cactgcttgg ctggctcaag attagggccg     3180

cggagggggc tgtgcacata ccagttactt aagcagccac gagtgtcccc catgccttgg     3240

tgcgggtcct ggaggcctct tgggggtggg acctttgggc agggtttgcc cactgacacg     3300

cccgccatgg ggcactggct gcatggggct ccttggaccc tgtagaccca gcaggagcct     3360

ggccgcgggg actgcaggga gggtgcctgg acccgtgggg ttgcttcatt gagataaagc     3420

acacttatca catagcacaa aggacgtgcc atggtgcttt ccccaaaagt tgtgttgctt     3480

ttatcagttt tctaactt                                                   3498


<210> 4215
<211> 2000
<212> DNA
<213> Homo sapiens

<400> 4215
gtagctggga ctacacgcac gcaccaccat gcccagctaa tttttgtatt agtagagacg       60

gggtttcacc atgttggcca gggttgtctc tatctcttga cctcatgatc agcctgcctt      120

ggcctcccaa agtactgcga ttacaggcgt gagccaccac gcctggcggg gatgcttaaa      180

tgtagcccaa tcctccagta aagaatacta agaaaaagtg tttggaaccg aaccaaaata      240

aaaacttgcg taccagaagt ttgcaggtaa tacagatatg cgtacatgac tggtgttcag      300

ctatttaggt ggacttgctt gtctctgctt acctgtgttg ctgatgctgg tcagcagtgg      360

agaaaactga gattagatgc tgctaatctc agatgggagg ataatttctt aggaggaagg      420

acatttcttg agtcatcagc tccagattcc tttaaagtgg tgaggcttca gcccagaggg      480

cgactaacat gagaattcct gtttgtgagg tcattgtcat gacctcatag ccaggctgtt      540

caaaatgttt gcccagcttc tggcaggata tgagctgatg cctgccccga ttctacagac      600

accatgagat ttaatccaga gactgacttc actatagaac ccacagttgt atcaatggtt      660

ggggaaagat agtggcaaca ggcaaaggag aaacagctct gacatacaaa gaaaatgagt      720

atgctaaagc caagtgggct taaggccccc accaagatcc tgaagcctgg aagcacagct      780

ctgaagacac ctacggctgt tgtagctcca gtagaaaaaa ccatatccag tgaaaaagca      840

tcaagcactc catcatctga gactcaggag gaatttgtgg atgactttcg agttggggag      900

cgagtttggg tgaatggaaa taagcctgga tttatccagt ttcttggaga aacccagttt      960

gcaccaggcc agtgggctgg aattgtttta gatgaaccca taggcaagaa cgatggttcg     1020

gtggcaggag ttcggtattt ccagtgtgaa cctttaaagg gcatatttac ccgaccttca     1080

aagttaacaa ggaaggtgca agcagaagat gaagctaatg gcctgcagac aacgcccgcc     1140

tcccgagcta cttcaccgct gtgcacttct acggccagca tggtgtcttc ctccccctcc     1200

accccttcaa acatccctca gaaaccatca cagccagcag caaaggaacc ttcagctacg     1260

cctccgatca gcaaccttac aaaaactgcc agtgaatcta tctccaacct ttcagaggct     1320

ggctcaatca agaaaggaga aagagagctc aaaatcggag acagagtatt ggttggtggc     1380

actaaggctg gtgtagtccg gtttcttggg gagaccgact ttgccaaggg ggagtggtgt     1440

ggcgtggagt tagatgagcc acttgggaag aatgatggcg ctgttgctgg aacaaggtat     1500

tttcagtgtc aacccaaata tggcttgttc gctcctgtcc acaaagttac caagattggc     1560

ttcccttcca ctacaccagc caaagccaag gccaacgcag tgaggcgagt gatggcgacc     1620

acgtccgcca gcctgaagcg cagcccttct gcctcttccc tcagctccat gagctcagtg     1680

gcctcctctg tgagcagcag gcccagtcgg acaggactac atgtcctgga attggaagcc     1740

aaaatggacc agctgcgaac aatggtggaa gctgctgaca gggagaaggt ggagcttctc     1800

aaccagcttg aagaggagaa aaggaaggtt gaggaccttc agttccgggt tgaagaagaa     1860

tcaattacca aaggtgatct tgagcaaaag agccagattt ctgaagatcc tgagaatgta     1920

agagggcact taactgtgtg gatatttccc ttgttaacaa agattgatca cagattaaaa     1980

tgcttattga tatactcaaa                                                 2000


<210> 4216
<211> 4102
<212> DNA
<213> Homo sapiens

<400> 4216
ctactgtgtg ctaggtacac ggcgttagag gggggtaggg atggatgtgg atagaatatt       60

gacgtataga agcctgtctt tgtctcaaga tacacaccca tttcaggagc agtgagtttt      120

caatgcctga agaaacaagg gctccaggat tcagagcccc tttaccctag ggaagaaaga      180

agaggttttc ttccctcccc tcttttacat ccagttcccc tgctccattt caaagcgttg      240

gcggtaaaga atgcatgttg agtatcaata ttccgtaaag cgaaagagcg taaagttatt      300

ttatgaaact ggtgaagcat gtttcagcgg tcgaaccaag atttaaagtt aggtccctac      360

cgcaaattca gcgctctttc ttatggtggt tactctgggt cctggacctg actgcctcat      420

tctggaggct tccagacagc cacagttagt gcccaaacct gagaggatgg cttcagatgg      480

agcatctgca ttgccgggac cggatatgag catgaaacct agtgccgccc cgtctccatc      540

ccctgcactt ccctttctcc caccaacttc tgacccacca gaccacccac ccagggagcc      600

acctccacag cccatcatgc cttcagtatt ctctccagac aaccctctga tgctctctgc      660

tttccccagc tcactgttgg tgacagggga tgggggccct tgcctcagtg gggctggggc      720

tggcaaggtc attgtcaaag tcaagacaga aggggggtca gctgagccct ctcaaactca      780

gaactttatc cttactcaga ctgccctcaa ttcgactgcc ccgggcactc cctgtggagg      840

ccttgagggt cctgcacctc catttgtgac agcatctaat gtgaagacca ttctgccctc      900

taaggctgtt ggtgtcagcc aggagggtcc tccaggcctt ccgcctcagc ctccaccacc      960

agttgctcaa ctggtcccca ttgtgcccct ggaaaaagct tggccagggc cacatgggac     1020

aaccggggaa ggaggtcctg tggccactct atccaagcct tccctaggtg accgctccaa     1080

aatttccaag gacgtttatg agaacttccg tcagtggcag cgttacaaag ccttggcccg     1140

gaggcaccta tcccagagtc ctgacacaga agctctttcc tgttttctta tcccagtgct     1200

tcgttccctg gcccggctga agcccactat gaccctggag gagggactgc cattggctgt     1260

gcaggagtgg gagcacacca gcaactttga ccggatgatc ttttatgaga tggcagaaag     1320

gttcatggag tttgaggctg aggagatgca gattcagaac acacagctga tgaatgggtc     1380

tcagggcctg tctcctgcaa cccctttgaa acttgatcct ctagggcccc tggcctctga     1440

ggtttgccag cagccagtgt acattccgaa gaaggcagcc tccaagacac gggccccccg     1500

ccggcgtcag cgtaaagccc agagacctcc tgctcctgag gcacccaagg agatcccacc     1560

agaagctgtg aaggagtatg ttgacatcat ggaatggctg gtggggactc acttggccac     1620

tggggagtca gatggaaaac aagaggaaga agggcagcag caggaggagg aagggatgta     1680

tccagatcca ggtctcctga gctacatcaa tgagctgtgt tctcagaagg tctttgtctc     1740

caaggtggag gctgtcattc accctcaatt tctggcagat ctgctgtccc cagaaaaaca     1800

gagagatccc ttggccttaa ttgaggagct agagcaagaa gaaggactca ctcttgccca     1860

gctggtccag aagcgactca tggccttgga agaggaggaa gatgcagagg cgcctccaag     1920

tttcagtggc gctcagttgg actcaagtcc ttctggttct gttgaggatg aagatgggga     1980

tgggcggctt cggccctcac ctgggcttca gggggctggg ggcgccgctt gccttggaaa     2040

ggtttcttct tcaggaaaac gggcaagaga agtgcatggt gggcaggagc aagccctaga     2100

tagccccaga gggatgcaca gggatgggaa cactctgcca tcccccagca gctgggacct     2160

gcagccagaa cttgcagctc cacagggaac tccgggaccc ttgggtgtgg agaggagagg     2220

gtctgggaag gttataaacc aggtatctct acatcaggat ggccatctag gaggcgctgg     2280

gcctcctggg cactgcctgg tggctgatag gacttcagag gctctgcccc tttgttggca     2340

gggaggcttc cagcctgaga gcactcccag tttggatgct ggacttgcag agctggctcc     2400

tctgcaagga caagggttag aaaagcaagt cctgggattg cagaaaggac aacaaacagg     2460

gggtcgtgga gtgcttcctc aagggaagga gcctttagca gtgccctggg aaggctcttc     2520

aggagccatg tggggagatg acagaggtac ccccatggct cagagttatg atcagaatcc     2580

ttcccctaga gcagctgggg agagggacga tgtctgtctc agcccaggag tttggctgag     2640

cagtgagatg gatgctgtag gcttggagct gcctgtacaa atagaggagg tcatagagag     2700

cttccaagtt gagaagtgtg taactgagta tcaggaaggc tgccagggac tgggctccag     2760

gggcaacatt tccctgggtc ctggagaaac cctagtacct ggggatacgg agagcagtgt     2820

gattccctgt ggaggcacag ttgcggcagc tgccctagaa aagagaaact attgcagctt     2880

gccaggacct ttgagggcca acagcccacc cttgaggtcc aaagaaaatc aagaacagag     2940

ctgtgaaacc gtagggcatc ccagtgatct gtgggcagaa ggttgcttcc cattgctaga     3000

aagtggtgat tccacactgg ggtcttccaa agaaaccctt ccacccacat gccaaggcaa     3060

tctccttatc atggggactg aggatgcctc ctccttgcct gaagccagtc aagaggcagg     3120

gagcagaggc aattcctttt ctcctctgtt ggaaaccata gaacctgtca acatactaga     3180

tgttaaagat gactgtggcc tccaactaag ggtcagcgag gacacctgcc cactgaatgt     3240

tcattcttat gacccccaag gagaaggcag ggtggatcct gatctgtcca agcctaaaaa     3300

ccttgctcct ttacaagaga gtcaggagtc ttacacaact gggactccca aagcaacatc     3360

ttctcaccag ggccttggaa gcactttgcc tagaagggga accaggaatg ccatagttcc     3420

gagagaaact tctgttagta aaacacacag gtcagcagac agggccaaag gaaaggagaa     3480

aaagaaaaag gaagcagagg aagaggatga ggaactctcc aactttgctt acctcttggc     3540

ctctaaactt agcctctcac caagggagca tcccctcagt cctcaccatg cctcaggagg     3600

tcagggcagc cagagagcat cccacctgct ccctgctgga gcaaaaggcc ccagcaaact     3660

tccatatcct gttgccaagt ctgggaagcg agctctagct ggaggtccag cccctactga     3720

aaagacaccc cactcaggag ctcaacttgg ggtccccagg gagaaacccc tagctctggg     3780

agtagttcga ccctcacagc ctcgtaaaag gcggtgtgac agttttgtca cgggcagaag     3840

gaagaaacga cgtcgtagcc agtagggagc agcgggacca tctgacccca cttgccagtc     3900

cctaaaggtg ggtgccccag agtagattcc acccctgctg cccaccaatg gagaatccca     3960

atgttgaatc tcatcccaat gttgttttgt tgttctgcaa aagtggcaag catggagaga     4020

gaggtcagac tggctaggct gcagggggaa ttacctttgg aaggagctat atagaaaaaa     4080

aatgaataaa gtgttttgtt gg                                              4102


<210> 4217
<211> 1677
<212> DNA
<213> Homo sapiens

<400> 4217
ctcaatagcc aatgtagaaa taaaaaccct tttgcagcgg ggcctcgacc tccccatcat       60

cagtttttcc agaggcctca aatacagcct cctagagcta ccatcccgaa cagcagtcct      120

tccattcgtc ctggtgcaca gacacccact gcagtgtacc aggctaatca gcacatcatg      180

atggttaacc atctgcccat gccgtaccca gtgccccagg ggcctcagta ctgtatacca      240

cagtaccgtc atagtggccc tccttatgtt gggccccccc aacaatatcc agttcaacca      300

ccggggccag gtccttttta tcctggacca ggacctgggg acttccccaa tgcttatgga      360

acgccttttt acccaagtca gccggtgtat cagtcagcac ctatcatagt gcctacgcag      420

caacagccgc ctccagccaa gagagagaaa aaaactataa gaattcggga tccaaaccag      480

ggaggtaaag acataacaga ggagattatg tctggaggtg gcagcagaaa tcctactcca      540

cccataggaa gacccacgtc cacacctact cctcctcagc agctgcccag ccaggtcccc      600

gagcacagcc ctgtggttta tgggactgtg gagagcgctc atcttgctgc cagcacccct      660

gtcactgcag ctagcgacca gaagcaagag gagaagccaa aaccagatcc agtgttaaag      720

tctccttccc cagtccttag gctagtcctc agtggagaga agaaagaaca agaaggccag      780

acatctgaaa ctactgcaat agtatccata gcagagcttc ctctgcctcc atcacctacc      840

actgtttctt ctgttgctcg aagtacaatt gcagccccca cctcttctgc tcttagtagc      900

caaccaatat tcaccactgc tatagatgac agatgtgaac tctcatcccc aagagaagac      960

acaattccta tacccagcct cacatcttgc acagaaacat cagacccttt accaacaaat     1020

gaaaatgatg atgatatatg caagaaaccc tgtagtgtag cacctaatga tattccactg     1080

gtttctagta ctaacctaat taatgaaata aatggagtta gcgaaaaatt atcagccacg     1140

gagagcattg tggaaatagt aaaacaggaa gtattgccat tgactcttga attggagatt     1200

ctcgaaaatc ccccagaaga aatgaaactg gagtgtatcc cagctcccat caccccttcc     1260

acagttcctt cctttcctcc aactcctcca actcctccag cttctcctcc tcacactcca     1320

gtcattgttc ctgctgctgc cactactgtt agttctccga gtgctgccat cacagtccag     1380

agagtcctag aggaggacga gagcataaga acttgcctta gtgaagatgc aaaagagatt     1440

cagaacaaaa tagaggtaga agcagatggg caaacagaag agattttgga ttctcaaaac     1500

ttaaattcaa gaaggagccc tgtcccagaa acatcgaatg aatgctgaaa ttcctagtct     1560

ggtttcttca gtggtgtgtt tgtgttttag tacaacctgc aaaagagtta ctccattgtc     1620

taaaaatgca aatgagaatt tccaaatata caaaatgcct ccaaggtata tgtcacg        1677


<210> 4218
<211> 791
<212> DNA
<213> Homo sapiens

<400> 4218
cgaaatggcg ctgctggccg aacacttgct gaagccgctg cccgcggaca agcagatcga       60

gaccgggccc ttcctcgagg cggtgtccca cctgccgccc ttcttcgatt gccttgggtc      120

cccagtgttt actcccatca aggcagacat aagcggcaac atcacgatga ggaagctgag      180

actcagaggg gttgaaggac tcgcttaagg tcacaagcaa gtacgtggca aagctgggat      240

tcagacccag gcctacctgg ctccatctca gaggccttcg ttcctggact tcttggaatc      300

ctcggaacct atttccactt gtccaccaaa gcaaaacttc agatacttgg tgtctgaggc      360

agtgtcagta gtggctggag aacatgaact ctgtaccaac tgtgtgacct tgggcaagtc      420

cgtgctcctc tgtgagcctc agtgtctctg cctgtaaaat gggataatga cagcaacatc      480

aggtttgcca ccaggatcat ataagaaaat caaagctgtg tacgacacca acccagccaa      540

gttccggacc ctgcagaaca tcctggaggt ggagaaagaa atgtatggag cagagtggcc      600

caaagtaggg gccacactgg cgctgatgtg gctgaaaaga ggcctccgct tcatccaggt      660

cttcctccag agcatctgcg acggggagcg ggacgagaac caccccaacc tcatccgtgt      720

caacgccacc aaggcctacg agatggccct caagaagtac catggctgga tcgtgcagaa      780

gatcttccag g                                                           791


<210> 4219
<211> 2716
<212> DNA
<213> Homo sapiens

<400> 4219
gcttccttgg attccgcgct tggcaacggc tcggcgtcgc gctttggcca accgctgcgt       60

cgtccctggg cccgaataac tgtcgcccgc ttccctcagc gtgaggtaca aatgatgcaa      120

aatgtgcacc tggctccaga gacagatgaa gatgatcttt attccggcta taatgactac      180

aatccaatct atgatatcga ggaattggag aatgatgcag cttttcagca agctgtgagg      240

actagtcatg gcagaagacc tccatccaag acatctctgg catcatcaat aggaagacca      300

atgacagggg ctattcagga tggagttact agacccatga cagcagtgag agcagctggt      360

tttaccaaag cagctttgag aggctctgca tttgaccccc ttagtcagtc aaggggccct      420

gcttcccctt tggaagccaa gaaaaaagat agcccagagg aaaaaataaa gcaattagag      480

aaggaagtaa atgagttggt agaagaaagc tgtattgcca atagttgtgg agacttaaaa      540

ttggccttag aaaaggcaaa agatgcagga agaaaagaga gagtcctggt gagacagcga      600

gaacaagtta caactccaga aaatatcaat ttggatttaa cttactcagt tcttttcaat      660

ttggccagtc agtattcagt taatgaaatg tatgccgaag cacttaacac ttatcaagtt      720

atagtcaaaa ataagatgtt tagcaatgca ggaatattga aaatgaatat gggaaatatc      780

tatttaaagc aaagaaatta ttccaaagcc attaaattct accgaatggc attagaccaa      840

gttccaagtg tcaataagca aatgaggatt aaaataatgc agaatattgg agttacattt      900

attcaggctg gtcagtattc agatgctatt aattcatatg agcacataat gagcatggca      960

ccaaatctga aggcaggcta caacctaact atctgttatt ttgctattgg agaccgagaa     1020

aaaatgaaga aggcattcca aaaattgatt actgttccat tagaaattga tgaagataaa     1080

tatatttcac caagtgatga tcctcatact aacttagtaa ctgaagctat aaaaaatgat     1140

cacctcaggc aaatggaacg tgaaaggaaa gccatggcag aaaaatatat tatgacatct     1200

gcaaaactca ttgctcctgt aattgaaaca tcttttgctg caggttatga ttggtgcgtg     1260

gaagtggtga aagcttctca atatgtagag ctagccaatg atctggaaat aaacaaagca     1320

gttacatact tgagacaaaa agactataac caagctgtag agatcttaaa agtgttggaa     1380

aaaaaggaca gtagagtgaa aagtgcagct gcaaccaatc tctcagccct gtattatatg     1440

ggaaaggatt ttgcacaagc cagcagctat gcagatatag ctgtgaactc tgatagatat     1500

aatccagcag ctcttactaa taaagggaat acagtttttg caaatggtga ttatgagaag     1560

gccgctgaat tctataaaga ggctctaaga aatgattctt cttgtactga agcactttat     1620

aatattggcc ttacctatga gaaactaaat cggctagatg aggctttgga ctgtttcctg     1680

aaacttcacg caatcctacg aaacagtgcc gaagttcttt accagatagc aaatatatat     1740

gaattaatgg aaaatcccag tcaagctatt gaatggctaa tgcaggtggt cagtgttatt     1800

ccaaccgatc ctcaagtttt atctaagcta ggagaattat atgatcgtga aggagataaa     1860

tctcaagcat ttcaatatta ctatgagtca tataggtatt ttccttgtaa tattgaagtc     1920

attgagtggc ttggagccta ttacattgac acccaatttt gggaaaaagc tattcagtac     1980

tttgaaagag cttctcttat acagcctaca caagtgaaat ggcagctgat ggtagctagt     2040

tgtttcagaa gaagtggtaa ctaccaaaaa gcattagata cttacaaaga tactcacaga     2100

aaatttccag aaaatgtcga atgtctgcgt ttcttagttc gtctctgcac agatcttgga     2160

ttaaaagatg ctcaagaata tgccagaaaa ctgaagaggt tggaaaaaat gaaagaaata     2220

agggaacagc gcataaagtc aggcagagat ggcagtgggg gctcccgtgg caaaagagaa     2280

ggaagtgcta gcggtgatag tggccagaac tatagtgcca gtagtaaagg tgaacgacta     2340

agtgccagac tcagagcttt acctgggaca aatgaacctt atgaaagtag cagtaacaaa     2400

gaaatagatg cctcctatgt ggacccactt ggccctcaaa tagaacgacc aaaaactgca     2460

gccaagaaaa ggatcgatga ggatgatttt gctgatgaag aattaggaga tgatttgctt     2520

ccagaataat attcacttta atatttatta aaggaaagaa attgccttat gagatcatcc     2580

tcatgttaaa ccttggatta aatatctaac ctgtaattat tttttttcac tgtcaaaact     2640

taagtaagtg tattctattc tgtatgtatg catttaagtt gtttttttct tttaaggaat     2700

aaaaacaggt aaaact                                                     2716


<210> 4220
<211> 1450
<212> DNA
<213> Homo sapiens

<400> 4220
aacttgtttc tggtggagcg gaaggcgcga gctgcggacc ctcacgcaga gatttgttgg       60

tgttaacgca tctgacatca actattcagc aggccgctat gacccctcag ttaagcctcc      120

ctttgacata ggtttcgaag gcattgggga ggtggtggcc ctaggcctct ctgctagtgc      180

cagatacaca gttggccaag ctgtggctta catggcacct ggttcttttg ctgagtacac      240

agttgtgcct gccagcattg caactccagt gccctcagtg aaacccgagt atcttaccct      300

gctggtaagt ggcaccaccg catacatcag cctgaaagag ctcggaggac tgtcggaagg      360

gaaaaaagtt ttggtgacag cagcagctgg gggaacgggc cagtttgcca tgcagctttc      420

aaagaaggca aagtgccatg taattggaac ctgctcttct gatgaaaagt ctgcttttct      480

gaaatctctt ggctgtgatc gtcctatcaa ctataaaact gaacccgtag gtaccgtcct      540

taagcaggag taccctgaag gtgtcgatgt ggtctatgaa tctgttgggg gagccatgtt      600

tgacttggct gtagacgccc tggctacgaa agggcgcttg atagtaatag ggtttatctc      660

tggctaccaa actcctactg gcctttcgcc tgtgaaagca ggaacattgc cagccaaact      720

gctcaagaaa tctgccagcg tacagggctt cttcctgaac cattaccttt ctaagtatca      780

agcagccatg agccacttgc tcgagatgtg tgtgagcgga gacctggttt gtgaggtgga      840

ccttggagat ctgtctccag agggcaggtt tactggcctg gagtccatat tccgtgctgt      900

caattatatg tacatgggaa aaaacactgg aaaaattgta gttgaattac ctcactctgt      960

caacagtaag ctgtaaaaac agaacaatga cataaatcaa gggagaaaga aaatgggcac     1020

tttatgtctc agaattactc aaatcaattt atttttagtt ggtaatggat ataatatttc     1080

ttaaaacaaa agtaaggtgt taatgaatag gtctctcctt ctcctcctcc tcctcctctt     1140

cccttggggg aaaaaaaaaa atgtgctaat aaaacttccc tccatggcta agagggaaaa     1200

cgcttacatt caattcttta gtcatggatg gtctcgttcc agatgttatt gttccaggga     1260

actaaattca ttcctgatgc cagatctgat cgagtcagta tgtcttcagc ttgatcagat     1320

tttaaaatca gttttgaaag tggttcccga cttctttgct ttgggagaat ttggtcttat     1380

gctcataagc agttcatgag tgacaagtgt agcaaaagcc agccatatat tttcagaatc     1440

tatatcctca                                                            1450


<210> 4221
<211> 1406
<212> DNA
<213> Homo sapiens

<400> 4221
agaccaacca gacccagatg ccattaagat gtttgtcgga cagatccccc ggtcatggtc       60

ggaaaaggag ctgaaagaac tttttgagcc ttacggagcc gtctaccaga tcaacgtcct      120

ccgggaccgg agtcagaacc ctccgcagag taaagatgca tcatcccatt cagatgaaac      180

ctgcagatag tgaaaagtcc aacgctgtgg aagacagaaa attgttcata ggaatggtat      240

cgaagaaatg taatgagaac gacatcaggg tgatgttctc tccatttggc cagatagaag      300

aatgccggat cctccgggga cctgatgggc tgagtcgagg ctgtgcgttt gtcacatttt      360

ctacaagggc aatggcacag aatgcaatca aagccatgca tcagtctcag accatggagg      420

gctgctcttc acctatcgtg gtgaagtttg ctgacactca gaaggacaaa gagcaaaggc      480

gcctccagca gcagctcgct cagcagatgc agcagctcaa cactgccacc tgggggaacc      540

tgacagggct gggcggactg accccacagt atctggcgct cctgcagcag gccacctcct      600

ccagcaacct gggtgcgttc agcggcattc aacaaatggc aggcatgaat gctttacagt      660

tgcagaacct ggcgacgctg gctgctgctg cagctgcggc ccagacctca gccaccagca      720

ccaatgcaaa ccctctctct accacgagca gcgccctggg agccctcacg agtcccgtgg      780

ctgcttcaac ccccaactcc actgctggtg cagccatgaa ctccttgacc tctctcggga      840

ctctgcaagg actggctgga gccactgttg gactgaataa tattaatgca ctagcagttg      900

ctcaaatgct ctcaggtatg gcggctctga atggaggact tggcgccaca ggcttgacga      960

atggcacggc tggcaccatg gacgccctca cccaggccta ctcaggaatt caacagtacg     1020

cagccgccgc gctgcccact ctgtacagcc agagcctgct gcagcagcag agcgctgcag     1080

gcagccagaa ggaaggtcca gagggggcaa acctctttat ttaccacctt ccacaggaat     1140

ttggagacca ggacattctg cagatgttca tgccttttgg aaatgttatc tctgctaaag     1200

tcttcattga caaacagacc aatctgagca agtgctttgg ttttgttagc tacgacaatc     1260

cagtctctgc acaagctgct atccaagcta tgaatggctt tcagatcggc atgaaacgct     1320

tgaaggtgca gctgaagcgt tccaaaaacg acagcaaacc ttactgatcc taaccccaga     1380

ggctccctgc tctcatttta gctttc                                          1406


<210> 4222
<211> 1696
<212> DNA
<213> Homo sapiens

<400> 4222
ttgtgggttg ctgggcggcc cggtctcgga gaagagggga gagtggcggg ccgctgaata       60

agcttccaaa atgatgccca caccagttat cctattgaaa gaggggactg atagctccca      120

aggcatcccc cagcttgtga gtaacatcag tgcctgccag gtgattgctg aggctgtaag      180

aactaccctg ggtccccgtg gcatggacaa gcttattgta gatggcagag tttctgaagc      240

aggtgaaacc ctatgtggag gaaggtttac acccccagat catcattcga gctttccgca      300

cagccaccca gctggcagtt aacaagatca aagagattgc tgtgaccgtg aagaaggcag      360

ataaagtgga gcagaggaag ctgctggaaa agtgtgccat gaccgctctg agctccaagc      420

tgatctccca gcagaaagct ttctttgcta agatggtggt ggatgcagtg atgatgctcg      480

atgatttgct gcagcttaaa atgattggaa tcaagaaggt acagggtgga gccctcgagg      540

attctcagct ggtagctggt gttgcattca agaagacttt ctcttacgct gggtttgaaa      600

tgcaacccaa aaagtaccac aatcccaaga ttgccctttt gaatgtcgag ctcgagttga      660

aagctgagaa agacaatgct gagataagag tccacacagt tgaggattat caggcaattg      720

ttgatgctga gtggaacatt ctctatgaca agttagagaa gatccatcat tctggagcca      780

aagttgtctt gtccaaactc cccattgggg atgtggccac ccagtacttt gctgacaggg      840

acatgttctg tgctggccga gtacctgagg aggatctgaa gaggacaatg atggcctgtg      900

gaggctcaat ccagaccagt gtgaatgctc tgtcagcaga tgtgctgggt cgatgccagg      960

tgtttgaaga gacccagatt ggaggcgaga ggtacaattt ttttactggc tgccccaagg     1020

ccaagacatg caccttcatt ctccgtggcg gcgccgagca gtttatggag gagacagagc     1080

ggtccctgca tgatgccatc atgatcgtca ggagggccat caagaatgat tcagtggtgg     1140

ctggtggcgg ggccattgag atggaactct ccaagtacct gcgggattac tcaaggacta     1200

ttccaggaaa acagcagctg ttgattgggg catatgccaa ggccttggag attatcccac     1260

gccagctgtg tgacaatgct ggctttgatg ccacaaacat tctcaacaag ctgcgggctc     1320

ggcatgccca ggggggtaca tggtatggag tagacatcaa caacgaggac attgctgaca     1380

actttgaagc tttcgtgtgg gagccagcta tggtgcggat caatgcgctg acagcagcct     1440

ctgaggctgc gtgcctgatc gtgtctgtag atgaaaccat caagaacccc cgctcgactg     1500

tggatgctcc cacagcagca ggccggggcc gtggtcgtgg ccgcccccac tgagaggcac     1560

cccacccatc acatggctgg ctggctgctg ggtgcactta ccctccttgg cttggttact     1620

tcattttaca aggaaggggt agtaattggc ccactctctt cttactggag gctatttaaa     1680

taaaatgtaa gacttc                                                     1696


<210> 4223
<211> 3652
<212> DNA
<213> Homo sapiens

<400> 4223
gccgtaaagc gctccgaggc ggagccgccg ccgcgcggcc ggggcttctc actctgacgg       60

gcccgcgcgc acgatggccg gcgccgcgcc gcgggtccgc tacctggcgg gcttctgctg      120

ccctctcggg ggcctggcgg cgggcaagcc ccgcgtgctg tgccatgagg cagaggtctt      180

cctgtccacc gggagcgagc tcgtctacgt gtacgaccag gagggcgggc tgctgaccgc      240

ggcgttccgg ttccccgacc aggtgtggca cctggagctg ctggcgccgc gcaggttgct      300

gtacgcgctg tgcgcccgga ggggcctcta ctgcctgtcg ctggaccacc cgggcaggag      360

caggtctacg agccaggatg acagggacag cgaggacggt gaccagcctt cccccgtgat      420

ccctgtggac cccgatgcct gcatccttcc cgatgctgcg ctgtgcgcgt tcaccttgct      480

ggacagtgtg ctggtcaccc tggtgcaggg ccctgcccga tggaagatgc agctgtttga      540

gcagccctgt cctggggagg acccccggcc aggaggccag atcggtgagg tggagctgtc      600

ctcctacacg cccccagccg gggtcccagg aaagcctgca gccccccact tccttccagt      660

gctgtgctct gtgtcaccat caggctccag ggtcccgcac gacctcctcg ggggctccgg      720

gggcttcacg ctggaggacg ccctcttcgg gctcctcttt ggagctgatg ccaccctcct      780

gcagtcacct gtggtcctct gtggtctccc tgatggccag ctctgctgtg tgatcctgaa      840

ggccctggtc acctccaggt cagcccctgg tgacccaaat gcccttgtca agatcctcca      900

tcacctggag gagcccgtca tcttcatagg ggccttgaag acagagccac aggctgcaga      960

agctgcagag aattttctgc ctgacgagga tgtgcactgt gactgcctgg tggcctttgg     1020

tcaccacggc cggatgctgg ccatcaaggc cagctgggat gagtccggga agctggtgcc     1080

cgagctgcgg gagtactgcc tcccaggccc tgtgctctgc gctgcctgtg gcgggggtgg     1140

ccgcgtgtac cacagcaccc cttctgacct ctgtgtggtg gatctgtctc ggggaagcac     1200

cccgctgggc cctgagcagc ccgaagaagg cccgggaggc ctgcccccca tgctgtgccc     1260

agccagcctg aacatctgca gtgtcgtctc gctgtccgcg tctcccagga cgcatgaagg     1320

tggcaccaag ctcctggccc tgtccgccaa aggccgcctg atgacctgca gcctggacct     1380

ggactctgag atgcctggcc cagccaggat gaccacagag agtgcaggtc agaaaataaa     1440

ggagctgctg tctggaattg gcaacatctc tgagagagtg tcttttctaa agaaggcggt     1500

tgaccagcgg aacaaggcac tgacaagcct caacgaggcc atgaacgtga gctgtgcact     1560

gctgtcaagc ggcacgggcc ccagacccat ctcctgcacc accagcacca cctggagccg     1620

cctgcagaca caggatgtgc tcatggccac ctgcgtgcta gagaacagca gcagcttcag     1680

cctggaccag gggtggaccc tgtgcatcca ggtgctcacc agctcctgtg ctctcgacct     1740

ggactcggcc tgctccgcca tcacctacac catccccgtg gaccagctcg gccccggtgc     1800

tcggcgggag gtgacgctac ccctgggccc tggtgagaac ggcgggctcg acctgcccgt     1860

gaccgtgtcc tgcacgctgt tctacagtct cagggaggtg gtgggcgggg cccttgcccc     1920

ctcagactct gaggacccct ttctggatga gtgcccctcc gacgtcctgc ccgagcaaga     1980

gggtgtttgc ctgcccctga gcaggcacac agtggacatg ctgcagtgtc tgcgcttccc     2040

tggcctggcc ccgccacaca cacgggcccc ctccccactc ggccccaccc gagaccctgt     2100

ggccactttt ctggaaactt gtcgggagcc tggcagccag ccagcaggac ccgcctccct     2160

gcgggccgag tacctgcccc catctgtggc ttccatcaag gtgtcggcgg agctgctcag     2220

agctgccttg aaggacggcc actcaggcgt gcccctgtgc tgtgccaccc tgcagtggct     2280

ccttgctgag aatgctgctg tggacgtcgt gagggcccga gcactatctt ccatccaggg     2340

agtggcccct gatggcgcca acgttcacct catcgtccga gaggtggcca tgactgacct     2400

gtgcccagca gggcccatcc aggccgtgga gattcaagtg gaaagctcct ctctggccga     2460

catttgcagg gcgcaccatg ccgttgtcgg gcgcatgcag acgatggtga cagagcaggc     2520

cacccagggc tccagcgctc ctgatctccg tgtgcagtac ctccgccaga tccacgccaa     2580

ccacgagaca ctgctgcggg aggtgcagac cctgcgcgac cggctctgca cggaggatga     2640

ggccagctcc tgtgccaccg cccagaggct gctacaggtg taccggcagc tgcgccaccc     2700

cagcctcatc ctgctgtgac caggcgggcc tgcccctggg ctctggccac gcttccagcc     2760

tctgtcacag cccccccagg cctcatgggt tagagggaaa ccgagctggc ctggccagag     2820

ccgtcaggga aggtaggacc tggccacgta ggagcagaac gctcatgaaa gtgcttggag     2880

gccgtggagc acaaagcaga ttctgattgg gagcaaccga ggcgggctct gaacctggcc     2940

ggtccagctt cgcgtcctct gctggtgtct ctccttctct gaccgcggcc gcagcccctg     3000

cactcgcctt cctcactgct gggcagcctt cccaccaccg cagcagcccc tgaggccagg     3060

aggcagtgca gggcattctg gacccggagg gccagagaaa caggatttct ggggtttgga     3120

cttggggtga gtttgtaact gttgctgcca caccaccagg agcaccggct gcccctctgg     3180

gtggcactac caggtgcccc acggtaccct tgtcacactg ttcacacctg cccggctgcc     3240

cactctggga ccccgaggta ggagggtgct ccctgagacc aaagcacaaa acagcatgca     3300

gggagctcct gcaagtgccc gtggtctcgt gccacaccaa ggaagggcca gcgggtggcc     3360

tgtggccgga atgctcaaca actaggtgcc tccagccggg gcagtaccca gcactgtgca     3420

ctattttcag ggccactcag ggtggcgctg tggcccgggg gggggccctg agccccagcc     3480

cccagcctcc tccctcagcc tgggctacgg cccacctcct ggtgctggtg ttttcatctg     3540

gggagggtgc tcgcgccgct cccgctgcag gcactgtccg cgatgagtgc gggtaggagc     3600

cgtgaggtgc ttctctgctg tgacaaacga ccctgtctgt ccgtgaacct tc             3652


<210> 4224
<211> 5229
<212> DNA
<213> Homo sapiens

<400> 4224
gtcacgctct cccccgcccc gagccgacga gccgggaggc gggaggcggc ggccgcggcg       60

gctgctgctg ctgcagtggg acaggtggcg gcgaccggcg gcgtccgagg agatttaatc      120

cagagactga cttcactata gaacccacag ttgtatcaat ggttggggaa agatagtggc      180

aacaggcaaa ggagaaacag ctctgacata caaagaaaat gagtatgcta aagccaagtg      240

ggcttaaggc ccccaccaag atcctgaagc ctggaagcac agctctgaag acacctacgg      300

ctgttgtagc tccagtagaa aaaaccatat ccagtgaaaa agcatcaagc actccatcat      360

ctgagactca ggaggaattt gtggatgact ttcgagttgg ggagcgagtt tgggtgaatg      420

gaaataagcc tggatttatc cagtttcttg gagaaaccca gtttgcacca ggccagtggg      480

ctggaattgt tttagatgaa cccataggca agaacgatgg ttcggtggca ggagttcggt      540

atttccagtg tgaaccttta aagggcatat ttacccgacc ttcaaagtta acaaggaagg      600

tgcaagcaga agatgaagct aatggcctgc agacaacgcc cgcctcccga gctacttcac      660

cgctgtgcac ttctacggcc agcatggtgt cttcctcccc ctccacccct tcaaacatcc      720

ctcagaaacc atcacagcca gcagcaaagg aaccttcagc tacgcctccg atcagcaacc      780

ttacaaaaac tgccagtgaa tctatctcca acctttcaga ggctggctca atcaagaaag      840

gagaaagaga gctcaaaatc ggagacagag tattggttgg tggcactaag gctggtgtag      900

tccggtttct tggggagacc gactttgcca agggggagtg gtgtggcgtg gagttagatg      960

agccacttgg gaagaatgat ggcgctgttg ctggaacaag gtattttcag tgtcaaccca     1020

aatatggctt gttcgctcct gtccacaaag ttaccaagat tggcttccct tccactacac     1080

cagccaaagc caaggccaac gcagtgaggc gagtgatggc gaccacgtcc gccagcctga     1140

agcgcagccc ttctgcctct tccctcagct ccatgagctc agtggcctcc tctgtgagca     1200

gcaggcccag tcggacagga ctattgactg aaacctcctc ccgttacgcc aggaagatct     1260

ccggtaccac tgccctccag gaggccctga aggagaagca gcagcacatt gagcagctgc     1320

tggcggaacg ggatctggag agggcggagg tggccaaggc cacgagccac gtgggggaga     1380

tagagcagga gctagctctg gcccgggacg gacatgacca gcatgtcctg gaattggaag     1440

ccaaaatgga ccagctgcga acaatggtgg aagctgctga cagggagaag gtggagcttc     1500

tcaaccagct tgaagaggag aaaaggaagg ttgaggacct tcagttccgg gttgaagaag     1560

aatcaattac caaaggtgat cttgaggtgg ctacagtttc agaaaagtca cgtataatgg     1620

aactggagaa agacctagca ttgagagtac aggaagtagc tgagctccga agaaggctag     1680

agtccaataa gcctgctggg gatgtggaca tgtcactttc ccttttgcaa gagataagct     1740

ctttgcaaga aaagttagaa gtcacccgta ctgaccacca gagagaaata acttctctga     1800

aggagcattt tggagcccgg gaagaaactc atcagaagga gataaaggct ctgtataccg     1860

ccacggaaaa gctttccaaa gagaacgagt cattgaaaag caagctggag catgccaaca     1920

aagagaactc agatgtgata gctctatgga agtccaaact ggagactgcc atcgcatccc     1980

accagcaggc gatggaagaa ctgaaggtat ctttcagcaa agggcttgga acagagacgg     2040

cagaatttgc tgaactaaaa acacaaatag agaaaatgag actagattac caacacgaaa     2100

tagaaaattt gcagaatcaa caagactctg aacgggctgc ccatgctaaa gagatggaag     2160

ccttgagggc taaactgatg aaagttatta aagaaaagga aaacagtctg gaagccatca     2220

ggtcgaaact ggacaaagca gaagaccagc atctcgtaga aatggaagac acgttaaaca     2280

aattacagga agctgaaata aaggtaaagg agctagaggt actgcaagcc aaatgcaatg     2340

aacaaaccaa ggttattgat aattttacat cacagctcaa ggctactgaa gaaaagctct     2400

tggatcttga tgcacttcgg aaagccagtt ccgaaggtaa atcggaaatg aagaaactta     2460

gacagcagct tgaggcagct gagaaacaga ttaaacattt agagattgaa aagaatgctg     2520

aaagtagcaa ggctagtagc attaccagag agctccaggg gagagagcta aagcttacta     2580

accttcagga aaatttgagt gaagtcagtc aagtgaaaga gactttggaa aaagaacttc     2640

agattttgaa agaaaagttt gctgaagctt cagaggaggc agtctctgtt cagagaagta     2700

tgcaagaaac tgtaaataag ttacaccaaa aggaggaaca gtttaacatg ctgtcttctg     2760

acttggagaa gctgagagaa aacttagcag atatggaggc aaaatttaga gagaaagatg     2820

agagagaaga gcagctgata aaggcaaagg aaaaactgga aaatgacatt gcagaaataa     2880

tgaagatgtc aggagataac tcttctcagc tgacaaaaat gaacgatgaa ttacgtctga     2940

aagaaagaga tgtagaagaa ttacagctaa aacttacaaa ggctaatgaa aatgcaagtt     3000

ttctgcaaaa aagtattgag gacatgactg tcaaagctga acagagccag caagaagcag     3060

ctaaaaagca tgaggaagaa aagaaagaat tggagaggaa attgtcggac ctggaaaaga     3120

aaatggaaac aagccacaac cagtgtcagg agctgaaagc caggtatgag agagccactt     3180

ctgagacaaa aaccaagcat gaagaaatcc tacagaacct ccagaagacg ctgctggaca     3240

cagaggacaa gctgaagggc gcacgggagg agaacagtgg cttgctgcag gagctggagg     3300

agctgagaaa gcaagccgac aaagccaaag ctgctcaaac agcggaagat gccatgcaga     3360

taatggaaca gatgaccaaa gagaagactg agactctggc ctccttggag gacaccaagc     3420

aaacaaatgc aaaactacag aatgaattgg acacacttaa agaaaacaac ttgaaaaatg     3480

tggaagagct gaacaaatca aaagaactcc tgactgtaga gaatcaaaaa atggaagaat     3540

ttaggaaaga aatagaaacc ctaaagcagg cagcagctca gaagtcccag cagctttcag     3600

cgttgcaaga agagaacgtt aaacttgctg aggagctggg gagaagcagg gacgaagtca     3660

caagtcatca aaagctggaa gaagaaagat ctgtgctcaa taatcagttg ttagaaatga     3720

aaaaaagaga atccaagttc ataaaagacg cagatgaaga gaaagcttcc ttgcagaaat     3780

ccatcagtat aactagtgcc ttactcacag aaaaggatgc cgagctggag aaactgagaa     3840

atgaggtcac agtgctcagg ggagaaaacg cctctgccaa gtccttgcat tcagttgttc     3900

agactctaga gtctgataag gtgaagctcg agctcaaggt aaagaacttg gagcttcaac     3960

tcaaagaaaa caagaggcag ctcagcagct cctcaggtaa tacagacact caggcagacg     4020

aggatgaaag agcccaggag agtcagattg atttcctaaa ttcagtaata gtggaccttc     4080

aaaggaagaa tcaagacctc aagatgaagg tggagatgat gtcagaagca gccctgaatg     4140

ggaacgggga tgacctaaac aattatgaca gtgatgatca ggagaaacag tccaagaaga     4200

aacctcgcct cttctgtgac atttgtgact gctttgatct ccacgacaca gaggattgtc     4260

ctacccaggc acagatgtca gaggaccctc cccattccac acaccatggc agtcggggtg     4320

aggaacgccc atactgtgaa atctgtgaga tgtttggaca ctgggccacc aactgcaatg     4380

acgacgaaac cttctgatga agcctccagt ggagaactgg gcttgctcag acgcactcgc     4440

attgacacaa cgtaacacca gcattgtgtg tgcagacttc aggagaactc atgttatttt     4500

ttaaccccgt caacaaatct aggaaaatat tttgatcttc aacaaattgc cctttagtct     4560

ccccgtatga gttagaataa taaatattta gtaggtgagt tttcacctcg aattttgttt     4620

tcttgatttt tacgtttgaa gacattgcac cagatgccat tacatttatt ggccccccga     4680

ccttgtagaa aaacccctac cctcacaata ccttatttaa gtaactttaa attatgccgt     4740

tacttttcat atttgcacta agatatttcc aggctgcatt tgtatattta gattttttgg     4800

ttaagctttg acactggaat gagttgaaaa aatgtgccat tttgcatttt catctactca     4860

tttaaagtat tttattctta ttcaaagaaa tatctgagct ctttgcacta cctgttatca     4920

gtagtgcctt tacttcaggc ttgataatac ttaggtgtga ttataaaatc atgaagcagg     4980

taaagggagg ggcaagcccc caaactgctg tggggacatt ttataatcta tatgctgcac     5040

ccacttaatc tactgtggtg ttttgtttat tagttttgca taatttcagc ttctatatat     5100

tgtatgtata tattttttaa aaatctatat tttgggaaaa aaacatacac aatgtgtctt     5160

tctttttgga catttacctt tttgaaaaag aaaacactta aaatgatcat taggacataa     5220

cagactagg                                                             5229


<210> 4225
<211> 735
<212> DNA
<213> Homo sapiens

<400> 4225
caacggaccc tacctcttgt agtgattctc ggggccacgg gcaccggcaa atccacgctg       60

gcgttgcagc taggccagcg gctcggcggt gagatcgtca gcgctgactc catgcagttc      120

tagatgagcg cttggataag agggtggatg acatgcttgc tgctgggctc ttggaggaac      180

taagagattt tcacagacgc tataatcaga agaatgtttc ggaaaatagg tattgaggct      240

ctgaaacaag taactaagag atatgcccgg aaacaaaacc gatgggttaa aaaccgtttt      300

ttgagcagac ctggtcccat tgtcccccct gtctatggct tagaggtatc tgatgtctcg      360

aagtgggaag agtctgttct tgaacctgct cttgaaatcg tgcaaagttt catccagggc      420

cacaagccta cagccactcc aataaagatg ccatacaatg aagctgagaa caagagaagt      480

tatcacctgt gtgacctctg tgatcgaatc atcattgggg atcgcgaatg ggcagcgcac      540

ataaaatcca aatcccactt gaaccaactg aagaaaagaa gaagattgga ctcagatgct      600

gtcaacacca tagaaagtca gagtgtttcc ccagaccata acaaagaacc taaagagaag      660

ggatccccag ggcagaatga tcaagagctg aaatgcagcg tttaagagac atgtccagtg      720

gcctttggaa aggtg                                                       735


<210> 4226
<211> 2299
<212> DNA
<213> Homo sapiens

<400> 4226
agttttgggc cgagctaggg cccgtgctgg aagcagtcct ttggtgctgg tttcggggac       60

accttggcac gcctggagcc ccccacatgg tggcctcggg caggagccca cgtgttcctg      120

ggaggtagaa aggggcctac tctctgtcct gcgcccagac tggggctggg ggacgggctc      180

ccggcggcag gcctgggcgg cgctaagaga ccatggcgag cccagggaaa gacaattatc      240

gaatgaagag ctataagaac aatgctctaa accctgaaga aatgagacga agaagagagg      300

aagagggcat tcagctccgg aagcagaagc gagagcaaca actttttaaa cggagaaatg      360

tggagctgat taatgaagaa gctgccatgt tcgatagtct tctcatggac tcttatgtga      420

gctctaccac tggggagagt gtgatcacaa gagagatggt ggagatgctc ttttctgatg      480

attctgacct gcagttagca accacacaga aattccggaa actgctctcc aaagagccta      540

gtcctccaat agatgaagtt atcaacactc caagagtggt ggatcggttc gtggagtttc      600

tgaagaggaa tgagaattgt acattacagt ttgaagctgc ctgggctcta acgaatattg      660

cctctggaac ctctcagcag accaaaattg tcattgaagc aggggctgtc cccattttta      720

tagagctgct taattcagac tttgaggatg ttcaggaaca ggcagtctgg gcactgggaa      780

acatagctgg agatagctct gtttgccgag attacgtctt gaactgttcc atccttaatc      840

ctttgttaac actccttacc aagtccacac gactgacgat gacacggaat gcagtctggg      900

ccctgtcaaa tctctgccga gggaaaaacc cacccccaga gtttgcaaag gtctctcctt      960

gtttgcctgt actgtctcgc ctactcttca gcagcgactc ggacttgctg gcagatgctt     1020

gctgggccct ttcttatctg tctgatggcc ccaatgagaa gatccaggca gtcatagact     1080

ccggagtctg ccggagattg gtagagctgc tgatgcacaa tgattacaaa gtggcttctc     1140

ctgccctgag agccgtgggt aacatcgtca ctggggatga catccagacc caggtcattc     1200

ttaactgttc agccctacct tgccttctcc acttgttgag cagtcccaag gagtcaatcc     1260

ggaaggaagc ttgctggact atttcaaata ttactgctgg caacagggct caaatacagg     1320

ctgttataga tgcaaatatc ttccctgtgt tgatcgaaat ccttcagaaa gcagagtttc     1380

gtacaaggaa agaggcagcc tgggccatca ccaatgccac atcaggagga acccctgagc     1440

agatcaggta cctggtctca ctgggctgca tcaaacccct atgtgacttg ctgactgtaa     1500

tggattcgaa gattgtgcaa gtggccctca atggactgga gaacatcctg cggcttggag     1560

agcaagaggg caagcgcagt ggctcagggg tcaatcctta ttgtggcctc atagaggaag     1620

cctatggctt ggataaaatt gagtttctcc agagccacga gaaccaggag atctaccaga     1680

aggccttcga cctcattgag cactactttg gtgtagaaga cgatgatagc agcctggctc     1740

cccaagtcga tgaaacgcaa cagcagttca tcttccagca gcctgaggcc cccatggagg     1800

gcttccagct ataatatctg cctccaggga ggggagggga tgggaagcac caccagccag     1860

cggaagagca gccctctggt gggcgggaaa ccagtgtccc caccatcagc caccacacac     1920

ctctgctgcc ctggagactg tgctcttgac ctgctccgcc cccttccctg gagggagcac     1980

cctctggaca gacagaacca tctgaggctc acctttgggt tttgtgacaa gaaggggacg     2040

tgttgggttt ttcttcctta cactatattt tggctgcaca catgtcttta acccaggagc     2100

ccaggggtag acaaaggagg actaaggtaa tcaatttgca ccttttttta tttttatttt     2160

ttttcttttt ttcttcagtg gtgacttcct tccctttatc ttttttcatt cttcccggtc     2220

ctctgccctg atctgtgtaa ctcttatctt gggtacttga gcagacggta tattccagag     2280

gtgggaggtg ggaggggaa                                                  2299


<210> 4227
<211> 1521
<212> DNA
<213> Homo sapiens

<400> 4227
ggcgacgggg cgctctcggg ctgccggcgg ggccgagcgc cgcgcgtccc gagcatggca       60

ggctccctgc ctccctgcgt ggtggactgt ggcaccgggt ataccaagct tggctacgca      120

ggcaacactg agccccagtt cattattcct tcattggccg atacgacatg gaatcattga      180

agactgggat cttatggaaa ggttcatgga gcaagtggtt tttaaatatc ttcgagctga      240

acctgaggac cattattttt taatgacaga acctccactc aatacaccag aaaacagaga      300

gtatcttgca gaaattatgt ttgaatcatt taacgtacca ggactctaca ttgcagttca      360

ggcagtgctg gccttggcgg catcttggac atctcgacaa gtgggtgaac gtacgttaac      420

ggggatagtc attgacagcg gagatggagt cacccatgtt atcccagtgg cagaaggtta      480

tgtaattgga agctgcatca aacacatccc gattgcaggt agagatatta cgtatttcat      540

tcaacagctg ctaagggaga gggaggtggg aatccctcct gagcagtcac tggagaccgc      600

aaaagccatt aaggagaaat actgttacat ttgccccgat atagtcaagg aatttgccaa      660

gtatgatgtg gatccccgga agtggatcaa acagtacacg ggtatcaatg cgatcaacca      720

gaagaagttt gttatagacg ttggttacga aagattcctg ggacctgaaa tattctttca      780

cccggagttt gccaacccag actttatgga gtccatctca gatgttgttg atgaagtaat      840

acagaactgc cccatcgatg tgcggcgccc gctgtataag aatgtcgtac tctcaggagg      900

ctccaccatg ttcagggatt tcggacgccg actgcagagg gatttgaaga gagtggtgga      960

tgctaggctg aggctcagcg aggagctcag cggcgggagg atcaagccga agcctgtgga     1020

ggtccaggtg gtcacgcatc acatgcagcg ctacgccgtg tggttcggag gctccatgct     1080

ggcctcgact cccgagttct ttcaggtctg ccacaccaag aaggactatg aagagtacgg     1140

gcccagcatc tgccgccaca accccgtctt tggagtcatg tcctagtgtc tgcctgaacg     1200

cgtcgttcga tggtgtcacg ttggggaaca agtgtccttc agaacccaga gaaggccgcc     1260

gttctgtaaa tagcgacgtc ggtgttgctg cccagcagcg tgcttgcatt gccggtgcat     1320

gaggcgcggc gcgggccctt cagtaaaagc catttatccg tgtgccgacc gctgtctgcc     1380

agcctcctcc ttctcccgcc ctcctcaccc tcgctctccc tcctcctcct cctccgagct     1440

gctagctgac aaatacaatt ctgaaggaat ccaaatgtga ctttgaaaat tgttagagaa     1500

aacaacatta gaaaatggcg c                                               1521


<210> 4228
<211> 1096
<212> DNA
<213> Homo sapiens

<400> 4228
atgagccggg agcggggatc caggagcgag gagccgggag cggggaacag ggagtcgggg       60

agccgggaac cagggctggc agcggccgcc atgagcacgg tggaccttgc tcgcgtgggc      120

gcgtgcatcc tgaagcatgc ggtgaccggg gaggccgtgg agctgcggag cctgtggcgg      180

gagcacgcgt gcgtggtggc cgggctgcgg cgcttcgggt gcgtggtgtg ccgctggatc      240

gcccaggacc tcagcagcct tgctgggctc ctggaccaac acggcgtgcg cctggtgggc      300

gtagggcccg aggccctggg tctgcaggag ttcctggacg gcgactactt cgcgggagag      360

ctctacctgg atgagagcaa gcagctttac aaggagctag gcttcaagcg gtacaacagc      420

ctgagcatcc tcccagcagc tctggggaag cccgtgcgtg atgtggctgc caagtcccca      480

ggcgactacg tccccaagga gcacatcctg caggtcctgg gcatctctgc ggaggtctgt      540

gccagcgacc cgcctcagtg tgacagagag gtgtgaggga ggcgaaggcc ctggcctccg      600

aggatctggg tggcgtctgc tgccctaggt gtgctggaag tccacttgga agaactgttc      660

cggaggcgct gggtcgggat gccgaacctc tcctgatccg ccggcagcaa cgagccatta      720

aaactgcagt tcctgaccac gcactgcttc gcaggctccg agccctgcat cctccacagc      780

ccccgccttg ctcactgttg ggccctcagg gcgggcaggg tggctgtgag tcccaggtgt      840

catcttcctg ctctgcgact ttctctggag accttgggcc tttggcctgt ggggcactgg      900

ggatggtaac ctcactgccc cgtcactccc ttcaaaggcg acagacccaa gcccacgtca      960

ggagaggagc gtggggtcag ctccagcagg gtcggggtca gtgcctgtgt ctggtggggg     1020

ccactcagga gagttgggtt ttcagggcag agatgggctt gattccacct ggtggggtgg     1080

gtggaccctg gagact                                                     1096


<210> 4229
<211> 1047
<212> DNA
<213> Homo sapiens

<400> 4229
aacacgattc atgatgtgtt ggatgtggaa gcagctgttg tgaacttgga taattctgtg       60

gttgacctgg agacccttca agctctctat gagaatagag cacagtcaga cgaactcgaa      120

aaaatagaaa agcatggccg atcttccaaa gacaaggaaa atgccaagtc tctggacaaa      180

cctgaacagt tcctttatga actgtcacta atccccaact tttcagagcg agtcttttgc      240

atcctgttcc agtccacatt ttcagaaagc atttgctcaa ttcgtcgcaa actggaatta      300

ctacagaaat tgtgtgagac attaaaaaat ggcccagggg ttatgcaggt tctaggtttg      360

gttcttgcct ttggcaacta catgaatgga ggaaataaga ctcgaggaca ggcagatggc      420

tttggattag acattcttcc aaaactgaaa gatgtcaaga gcagtgacaa tagcagaagc      480

cttttgtcat atattgtttc gtattatctc cgaaattttg atgaggatgc tggaaaagaa      540

cagtgcctct ttccactgcc agaaccccag gacctttttc aggcctcaca gatgaagttt      600

gaagattttc aaaaagatct cagaaaactg aagaaagact tgaaagcctg tgaagttgaa      660

gcagggaaag tataccaggt ctcctcaaaa gagcatatgc agcctttcaa ggaaaacatg      720

gaacaattta ttattcaagc caaaattgac caagaggcag aggaaaattc actgacagag      780

actcataaat gctttttgga gaccacggca tatttcttca tgaaaccaaa acttggagag      840

aaggaggtgt ccccaaatgc tttcttcagt atctggcatg aattcagctc tgactttaaa      900

gacttctgga agaaagagaa caaacttctt ctacaagaga gagtaaaaga agccgaagag      960

gtgtgtagac agaagaaagg aaaatcactt tataaaataa aaccaagaca tgactctgga     1020

attaaaaaca ataatagcat gcacacc                                         1047


<210> 4230
<211> 878
<212> DNA
<213> Homo sapiens

<400> 4230
gtggccgata gctggtcctc tttctccaac acctagcctg agacttggcg gcgcggctgc       60

tatcctgaac tagcttggta agtgttgtgt cccgaaccag cgtagagaga cctcggacca      120

gccgccttga tgacagcatc cgcgtcctcc ttttcatcat ctcagggtgt ccagcagccc      180

tccatctaca gcttctccca aataaccaga agcttgtttc tcagcaatgg tgtggccgcc      240

aacgacaaac tccttctgtc cagcaatcgc atcaccgcca ttgtcaatgc ctcggtggaa      300

ggtcaacgta ttcttcgagg gattcagtac ataaaggtgc ctgttaccga tgctcgtgac      360

tcgcgtctct acgacttttt tgaccccatt gctgatctta tccacaccat cgatatgagg      420

cagggccgta cgctgctgca ctgcatggct ggagtgagcc gttccgcctc actgtgcctt      480

gcgtacctca tgaaatacca ctccatgtcg ctgctggacg cccatacatg gaccaagtcg      540

cgccgcccca tcatccggcc caacaacggc ttttgggaac agctcatcaa ttacgaattc      600

aagctgttta ataacaacac cgtgcgcatg atcaactcgc cggtaggtaa catccctgac      660

atctatgaga aggacctacg tatgatgata tcaatgtaag ccatcccggc cagcccctga      720

catctgccat cgatcttgca ccaagactga acttgaacac tgacattttg ttagtaaaga      780

aaaccggatg gtgccttgtt aaagggcaag aaaaaaggga gggggttgga gttttgaacg      840

tagtaagcct taccttaata gaattaaatt catgaaac                              878


<210> 4231
<211> 892
<212> DNA
<213> Homo sapiens

<400> 4231
cctatcgagc cctggctctc cgggcagctg gaggggtcgc gctgcgcctg ttggggctgc       60

acctcggacc agggcttctg ctgcatctgc agccatgtcg ggccgctcag tgccacatgc      120

ccacccggcc accgccgagt acgaatttgc caacccgagc cgcctgggtg agcagcgctt      180

cggagaaggc ctcctgccag aagagatcct gacccccaca ctctaccatg gctactatgt      240

ccggcctcgg gccgccccag ctggggaggg cagcagggca ggggcctccg agcttaggct      300

cagtgagggc aagttccagg catttctgga tgtgagccac tttaccccag acgaggtgac      360

tgtgaggact gtggataacc tgctggaggt gtctgcccgg cacccccagc gcctggaccg      420

ccacggcttc gtgtcccgag agttctgccg cacctatgtc ctgcctgctg atgtcgaccc      480

ctggcgagtc cgagctgctc tctcccatga tggcatctta aacctggaag cacctcgggg      540

tggccgacat ttggacacag aggtcaatga ggtctacatc tccctgctcc ctgcgcctcc      600

tgatccagag gaagaggagg aggcagccat agttgagccc tgattgccac agacccagca      660

cccagcaaat ccctctctac ctcccaaggt gatatgggca gctgcccacc actccagagg      720

tttcttttta ttgaagcttg aagctcaagt tcatggcttc atcaaaagac gcttcaaatc      780

ctgaagttga gatagctctc acctggagcc cgtgtgttgt tctacccttt ggctgggaac      840

acagtcacct gggaatcatt ccagcaggtg gcttcaaaag tccaacctgc ta              892


<210> 4232
<211> 967
<212> DNA
<213> Homo sapiens

<400> 4232
cttctcgcct aacgccgcca acatggtgtt caggcgcttc gtggaggttg gccgggtggc       60

ctatgtctcc tttggacctc atgccggaaa attggtcgcg attgtagatg ttattgatca      120

gaacagggct ttggtcgatg gaccttgcac tcaagtgagg agacaggcca tgcctttcaa      180

gtgcatgcag ctcactgatt tcatcctcaa gtttccgcac agtgcccacc agaagtatgt      240

ccgacaagcc tggcagaagg cagacatcaa tacaaaatgg gcagccacac gatgggccaa      300

gaagattgaa gccagagaaa ggaaagccaa gatgacagat tttgatcgtt ttaaagttat      360

gaaggcaaag aaaatgagga acagaataat caagaatgac acgagatagg aaataaacga      420

actgatagtg tagaggactg gctcgggacc acatcaagga agtaggttag tggttagatc      480

gtgtagggga acacgggaag ctactgaggg ttttttaaaa tggcgtgata tctcagattt      540

agatcattga actgttaaga ctgaatctta tgggatcaag actgggaatg ctcgggttgg      600

cagtatgaag tttggcagta atccaaggaa gtgacagtgg taatgccatt taggtggtct      660

tgatcatgca ttggactgca gaaataaggg agaaaacaat gtgtcagggt ttctggtttg      720

tacctctggt tcattggttg tgagggaaca tgaggcaggg taaagtttat ctaggtaaaa      780

tgagttagtt ttcatgtaga ctatctgggt gtatatgcaa agactgcaga caatctatac      840

taaaatcctg gctctgcctc ttgaaagcta tgtagtttag gcacatagtc aaaatccagt      900

ttcctcatct atgtggtacg cttcagagta gttaatcatg atatgtagtc cagtgactgg      960

ttccctt                                                                967


<210> 4233
<211> 874
<212> DNA
<213> Homo sapiens

<400> 4233
caacggaccc tacctcttgt agtgattctc ggggccacgg gcaccggcaa atccacgctg       60

gcgttgcagc taggccagcg gctcggcggt gagatcgtca gcgctgactc catgcaggag      120

cttgcaagtt tttgaagaaa caggaatctc tcatagtgaa tttctccatc gtcaacatac      180

ggaagaaggt ggtggtcccc ttggaggtcc tctgaagttc tctaaccctt gcatcctttg      240

gcttcatgct gaccagttct agatgagcgc ttggataaga gggtggatga catgcttgct      300

gctgggctct tggaggaact aagagatttt cacagacgct ataatcagaa gaatgtttcg      360

gaaaataggt attgaggctc tgaaacaagt aactaagaga tatgcccgga aacaaaaccg      420

atgggttaaa aaccgttttt tgagcagacc tggtcccatt gtcccccctg tctatggctt      480

agaggtatct gatgtctcga agtgggaaga gtctgttctt gaacctgctc ttgaaatcgt      540

gcaaagtttc atccagggcc acaagcctac agccactcca ataaagatgc catacaatga      600

agctgagaac aagagaagtt atcacctgtg tgacctctgt gatcgaatca tcattgggga      660

tcgcgaatgg gcagcgcaca taaaatccaa atcccacttg aaccaactga agaaaagaag      720

aagattggac tcagatgctg tcaacaccat agaaagtcag agtgtttccc cagaccataa      780

caaagaacct aaagagaagg gatccccagg gcagaatgat caagagctga aatgcagcgt      840

ttaagagaca tgtccagtgg cctttggaaa ggtg                                  874


<210> 4234
<211> 1335
<212> DNA
<213> Homo sapiens

<400> 4234
gtgacgcacc ggcgccgcgg cggagccgct cccgaggccc cggcgcggcg cgagggcgcg       60

gggcgcggcg tccacaggcg ccgaggctgc ccccgccgcc ccgcccgcga agatggcggc      120

ggaactctac gctcccgcca gcgccgcggc cgcggaccta gccaacagca acgccggcgc      180

cgccgtgggc aggaaggccg ggccgcgcag cccgcccagc gcccccgcgc cagcgccgcc      240

gccgcccgcg cccgcgccgc ccacactcgg caacaaccac caggagagcc ccggctggcg      300

gtgctgccgc cccacgctgc gcgagaggaa cgcgctcatg ttcaacaacg agctcatggc      360

cgacgtgcac ttcgtcgtgg ggcccccggg ggcgaccagg acggtgcccg cccacaagta      420

cgtcttggct gtcggcagct ccgtcttcta tgccatgttc tacggagacc tggcggaagt      480

caaatctgaa attcacattc cagacgtgga gcccgcagcc tttctgatcc tcttaaagta      540

catgtacagt gatgagatcg atctggaagc cgacacggtg ctggccactc tgtacgctgc      600

taagaagtac atcgtcccag cattggcaaa agcctgtgtc aactttctgg agacaagttt      660

ggaagccaag aacgcctgcg tcctgctgtc ccagagccgg ctgtttgagg agcccgagct      720

gacgcagcgc tgctgggagg tcattgacgc acaggccgag atggccctac ggtccgaagg      780

cttctgtgag atagaccggc agacgctgga gatcattgtc actcgggagg ccctcaacac      840

caaagaggcg gtggtcttcg aggccgtcct gaactgggcc gaggcggagt gcaagaggca      900

ggggctgcca atcaccccac gaaacaagag gcatgttctg gggcgagccc tctatctggt      960

ccgaattcca accatgaccc tagaggagtt tgccaacggc gctgcccagt cagacatcct     1020

gactctggag gagacccaca gcatcttcct gtggtacacg gccaccaaca agccccgcct     1080

ggactttccc ctgaccaaga ggaagggcct cgccccgcag aggtgccacc gattccagtc     1140

ttctgcctac cgcagcaacc agtggcggta ccgcgggcgc tgcgacagca tccagtttgc     1200

agtggacaga agggtattta ttgcagggct gggcctgtat ggctccagct ctgggaaggc     1260

tgagtacagc gtgaagattg agctcaagcg gctcggggtg gttctggctc agaacttgac     1320

caagttcatg tcaga                                                      1335


<210> 4235
<211> 1037
<212> DNA
<213> Homo sapiens

<400> 4235
cttctcgtcg gtgttcccgg ctgctataga gccgggtgag agagcgagcg cccgtcggcg       60

ggtgtcgagg gcgggttgcc tcgcgctgac ccttcccgcc ctccttctcg tcacacacca      120

ggtccccgcg gaagccgcgg tgtcggcgcc atggcggagc tgacggctct tgagagtctc      180

atcgagatgg gcttccccag gggacgcgcg gagaaggctc tggccctcac agggaaccag      240

ggcatcgagg ctgcgatgga ctgtttgttt gtaggatctg gttctgctgc cggagaaggc      300

aaacccgctt tgagtgaaga ggaaagacag gaacaaacta agaggatgtt ggagctggtg      360

gcccagaagc agcgggagcg tgaagaaaga gaggaacggg aggcattgga acgggaacgg      420

cagcgcagga gacaagggca agagttgtca gcagcacgac agcggctaca ggaagatgag      480

atgcgccggg ctgctgagga gaggcggagg gaaaaggccg aggagttagc agccagacaa      540

agagttagag aaaagatcga gagggacaaa gcagagagag ccaagaagta tggtggcagt      600

gtgggctctc agccaccccc agtggcacca gagccaggtc ctgttccctc ttctcccagc      660

caggagcctc ccaccaagcg ggagtatgac cagtgtcgca tacaggtcag gctgccagat      720

gggacctcac tgacccagac gttccgggcc cgggaacagc tggcagctgt gaggctctat      780

gtggagctcc accgtgggga ggaactaggt gggggccagg accctgtgca attgctcagt      840

ggcttcccca gacgggcctt ctcagaagct gacatggagc ggcctctgca ggagctggga      900

ctcgtgcctt ctgctgttct cattgtggcc aagaaatgtc ccagctgagg gcctttgtcc      960

cattgtccct ctgtgacccc ttcatctttg ataaagcact gacatctcct tcctaataaa     1020

tagaccctga gttctgt                                                    1037


<210> 4236
<211> 3768
<212> DNA
<213> Homo sapiens

<400> 4236
agggtccgcc agctcggggc cagcgcatgg ggctgctgag accgctccgg acgtgcgaag       60

cgttcgcggt gcggtggaga agaccaagct ttcttcctcc gaggagttcc ctcagactct      120

gagccttccc agaacaacaa ctatttgctc aggacatgat gctgataccg aagatgatcc      180

atccctagca gatttgcccc aggcactgga cctcagccag cagcctcaca gctcaggtct      240

ctcttgcctg tcacagtgga agtccgtgct gagcccaggt tccgcagctc agccttccag      300

ctgcagcatc tctgcttcct ccacaggcag cagtctccag ggtcaccagg agagggcgga      360

gcctcgtggt ggttctctgg ccaaggtctc ctcctccctg gagccggtcg tcccccagga      420

accttcctct gtggtggggc taggacctcg gccccagtgg tcaccacagc ctgtgttctc      480

tgggggtgat gcttctgggc taggcaggag acgcctctcc ttccaggctg agtactgggc      540

ctgtgtgctg ccagattccc tgcctccatc acccgaccgc cactcccctc tctggaaccc      600

aaataaagag tatgaagatc tgcttgacta tacttaccca ctgaggcccg ggcctcagct      660

cccaaagcac cttgatagcc gtgtgccagc tgaccctgtc ctgcaggact ccggggtaga      720

cctggatagc ttctctgtct ctccagcaag caccctcaaa tcacctacta atgtctcccc      780

caactgccca ccagcagagg ccactgccct gccattttct gggcccagag agccaagcct      840

taagcagtgg ccctccagag taccccagaa acagggtggc atgggcttgg catcttggag      900

ccaacttgca tctaccccca gagccccagg cagtagggat gctcgttggg agcgcagaga      960

gccagccctg aggggtgcga aggaccggct gactataggc aagcaccttg atatgggctc     1020

tccccagcta aggacacggg acagagggtg gccctcgccc aggccagaga gggagaagag     1080

gaccagccag agtgcccggc gccctacctg cacagagtct aggtggaaat cagaagagga     1140

agtggaaagt gatgacgagt atcttgccct ccccgctcgg ctgacacagg tttctagcct     1200

ggtttcgtat ctaggatcca tttctacctt ggttaccctg cccactgggg atatcaaagg     1260

gcagagcccc ttggaagtgt cagacagtga tgggccagct tccttccctt caagctccag     1320

ccaaagccag cttccccctg gagctgccct ccaaggatct ggggatcctg agggccagaa     1380

tccctgtttc ctgcgctcct tcgtccgtgc ccacgactcc gcaggggaag gcagtctggg     1440

gagcagccag gccctcgggg tctcctctgg actgctgaaa acacgcccct ccttgccagc     1500

taggttggac cggtggccat tctcagaccc agatgttgaa gggcagcttc ccaggaaagg     1560

aggagaacag ggaaaagaat cactggtgca atgtgtgaag gtaatgacac tcaacgttag     1620

gaagctttgt gtacaggtgt cttgtctctt cccccaatcc actaacatca taataaaaca     1680

tgttcatgtt gaccaggcac tttttatgtg ccaggcattg tgctgtacct tatcttattc     1740

agtcctcaca acttttacca ggtaagcact gttctcattt tactttttgg aggaaagagc     1800

agagagaggt taggtaacgt gcccacttat aattagcaag ggcttgagcc aagaatgaga     1860

cccaggtaga ctatttgcag aggctgagct cttagccact acccttggct gcttcctaac     1920

tcagaggtat tctgaacaaa aaaggttttg tgcacagatg cctttaggaa acactgggct     1980

aaacaaaggt aagtggcttt cttgactgca ggacttctag agcttcattt gccacagtgg     2040

tttaagtgca aagttagggg cattggatgt actgttgcct agactttgtg gccaccggac     2100

catcttgtga accaaatgac ttaatatctg gaggtataaa gaacactgcg tggaataggg     2160

ttatcggtgt caggcatctg aatttgaaac atggcactgc tgtctttgga atgttggctc     2220

agcctcttga gtttgctcat ttgtaaaatg tggagccctg ccttcttagg atgttgtgtg     2280

cattaaataa ttcatgttga gggcttcggt gcattcccag acatgttgaa ggttcaggaa     2340

tgtgcctgtc caggaacgtg tcctagcgct tgcggggggc tttcaccttc ccaggaggtg     2400

acgtggttat tttgtcttgt gaggtaggta ggacacgtta tcatggaccc ctctttactg     2460

ataaaagatt gagatgccat gaggtaaagt tgttcttcgc tatagcttca ggttagtcat     2520

gattttagtc atttatttta cgttcacttt tccagagaaa catggacgta tctggctcca     2580

agatgctgat tctagttagt aatggtgctg atccaagaat tggtttccat ggcaggcacg     2640

cctcttctgg gctgctccat tcctacctgc aaggctgggt tttctcagcc tgtcattttt     2700

gatgtcacac caggctgtgg ttttcattgc tttggcagag ggaggtacag agtcgtggag     2760

tcgggacagg tgagcaagga ggagagagga aactgaagac attttgctgt cagctggaag     2820

agctgatctg ctggctgtat aatgttgcag atgttactga ccacgggact gcagccaggt     2880

ccaatcttac aagtctcaag tcttctctgc agctttaccg ggtaatatgc ggtcctggct     2940

ctggcttgtt ccctcacaag agtgtggcta aattactcga ttacaaagta aaatctcaaa     3000

taaccaatgt ctggtatgtt atagctcagt tgactattat acctgaaatc taattagagc     3060

ttcacattct taaagcggaa cgctttgtaa aatgcatgaa ttatttccca ggccaaatgg     3120

agcttgaaga tacaatatat ttatctcaaa tcaaaaatac tttaggtttt gggctggcag     3180

gtgcagtggg acaagtcttt tatcccagct actctggaag ctgagacagg aagattgctt     3240

gagcccagga gttcgagtac agcctgagca acatagcaag accccccccc ctcaaaaaaa     3300

agttttttct taattaaaaa caaaaatact ttagggtgat ttgcaatata attttccaaa     3360

tgtctcaggg attataaata cagacttgca ctattatgac gcctctagtt atgtatggct     3420

attgaagtaa aattaaagac tcagattttt ttatttgcac tagccacatt ctgcatgttc     3480

aaccatcaca tttgtctagt ggctaccacg tagaacagtg cagatgtaga acacttccat     3540

caccacataa agtcctattg gactgcacca ctatttaaag atctgagctg aaattgtact     3600

gactccagaa tctacaatag ggcattttga tggtatttaa atagaaatct aggccaggca     3660

ccttggctca cactattaat cccagcactt tgggatgctg aggctggagg atcgcttgag     3720

cccgggagtt ccagaccagc ctgggcaata tagtgagacc tcgtctct                  3768


<210> 4237
<211> 4391
<212> DNA
<213> Homo sapiens

<400> 4237
aagcgcgcat gcgcgcttcg tcacaagggt gcgaggaaag tcagtgagca aatcgcggac       60

caccggggct gccagctcgc ctgactcccg gcctcttgcg ctcctagggg cggagaaggg      120

tgcgggctct tcgccctttg tgtcctcctt ctttcactaa cttctggact ttccagctct      180

tccgaagttc gttcttgcgc aaagcccaaa ggctggaaaa ccgtccacga tgaccagcat      240

gactcagtct ctgcgggagg tgataaaggc catgaccaag gctcgcaatt ttgagagagt      300

tttgggaaag taacacgtgg aggaacatac gttgggaata tcaactgaca cgcactgtgc      360

taggatctag aaataccatg tggactccaa cacacataga aataaggaag tggaattcca      420

aaggaaggca aagtgtaaag tcatctttat ggaaatgagt gatgaaggtg aatacctgaa      480

tgagatgtca agaggaggaa cacactggag agaagcagta aagatttagg actgaacctt      540

aaagacatac aggcttgaga gaaagaaagc atgtaaagaa gacagaaatg gttagaaaga      600

ttactcttgt ctctgctgct cctgggaaag tgatttgtga aatgaaagta gaagaagagc      660

ataccaatgc aataggcact ctccacggcg gtttgacagc cacgttagta gataacatat      720

caacaatggc tctgctatgc acggaaaggg gagcacccgg agtcagtgtc gatatgaaca      780

taacgtacat gtcacctgca aaattaggag aagatatagt gattacagca catgttctga      840

agcaaggaaa aacacttgca tttacctctg tggatctgac caacaaggcc acaggaaaat      900

taatagcaca aggaagacac acaaaacacc tgggaaactg agagaacagc agaatgacct      960

aaagaaaccc aacaatgaat atcaagtata gatttgactc aaacaattgt aatttttgaa     1020

ataaactagc aaaaccagaa gcagctagaa atattcttgg aggaaaagga cctggatatc     1080

aagtagggta aaggtggggg tgtctttttt cactttaagc atcttgtttt ctaatcatgt     1140

gtgataattg ggtgaaaaat tcttagctca aagtgtttta aaaacaggta aagcaaagaa     1200

actagcagga ccactctcag ttaagattaa aactaaagtc cagtgttaag ctaaaggaga     1260

aatagaaatt aatggttcta attctgtttg ggctgctagg aacaacagaa atttttcatg     1320

gttctagaag ctggaaagtc ctgggtcaag gcccagcaga tcctgttagg tgagggcccg     1380

cttcctggct catagatggt gccttctcac tgtgtggtgg aaggggcaag tgagccctct     1440

gggttctcgt ttttgaaatg gagtctcgct ctgttgccca ggctggagta cagcagcacg     1500

atctcggctc actgcaatct ctgccccctg ggttcaagtg attctcctgc ctcagcctcc     1560

caagtagctg ggactatagg catgtgccat cacacctagc taatttttgt agttttttgt     1620

agaaacaggg ttcaccatgt tggccaggct ggtctcgaac tcgtgacctc aggtgatccg     1680

cctgccttgg ccccccaaag tgctgggatt acaggtgtga gccaatgtgc ccagcctggg     1740

ttctcttttg taagggcact tactccaatc ttgagggttc tgccctcgtg atctaataac     1800

ttcccaaaga cccccacctg ctaatatcac cttgggggtt gggattttaa catacaaatt     1860

taggggaaac acatggagac cacagcaatg gccaatcctt agcgaatctt aggtccttcc     1920

cagatctaaa atgccaagct acacttgcat ttcctttttt taagattatg aaacttcaaa     1980

atatatgaac tacagcccat attgaaaaat aaaatagatt gagccatatg cctaaaaaag     2040

acctcaagaa aagtttgagg ctaagcatgt tagtgttaca ggaaatggtc caatagaggg     2100

ggaagaaaaa aagcatgcta ctagcccctt ttcttgtacc gagaataaaa ccatgcagat     2160

ctcaaacctc caagtctata gtattgaaaa gaccaagttc acttctcaga agtctccaag     2220

ttcagttgac tgtggcactc tgagacagct tctgtcactc aggctggagt gatacaatca     2280

cagcttccca tagcctcaaa atcccaggct caagacattc ttccacctca gtctcctgag     2340

tagctggaac tacaggcgtg tgccaccacg cctaatttta tttttgtaga aacaaggtct     2400

cactgttgcc cagcctcgtc tcaaactcct aggctcaagc aatcctcctg ccttggcccc     2460

ccaagtactg gacttacagg tgtgaaccac tgcacccagc tgactcttac ttgatttctg     2520

tcagggaatc ttaatgaaca tttcatgact aaagactaaa aaggatgcag ctttaagtaa     2580

atttaagtca agttaacagt taaagacaaa tcctttccct acattagatc gcctgctgat     2640

ctgtccactg tgaaagggca gaagactcca cagtagcaat agcagcagtg agcatacagg     2700

agtcccagat gtttacttct agtatttccc actaaaagga agctgggctc cttggagaaa     2760

cagctgactc cagggcttga ggctgggaca gaaaggttac agtatcttat gcatgaaagg     2820

agatgctcaa aataataaag gcatgcaaat tatgatttgg agggaaaaaa tatgaggcca     2880

tagtgtttag gtagataata aatggcagag atagaacact ctcttacaac aaatgctgta     2940

aatggacaaa gcattagatt tggaaaatca ctattttgta accatcatag ttaaagactg     3000

gtttgggttt tagtctggaa agaatcgcca agggagctcc tgataaagga acagggtatt     3060

tgcacattgc ttcccagaga ttgctagtag taagtaccac acatagggca aaaccaggac     3120

accttgacca ggcgctcaaa agtaacatca atgaagagca gatggagagt atacttgaga     3180

agggcgttaa gcatgaataa acaattcaaa tgcaaaatga gtaacaattt acaagaaaaa     3240

ttgccctgta ctccaaaaaa catagaggtc atggaacaca taaaggctaa ggaactgttc     3300

cacattaaag acaactgaga acaactaaat tcaatgatcc tgtactctag agggggggat     3360

ctaaaacaag ctaccaagga tactgggaca acaaaacgaa tatggatgat aaagagtatc     3420

aacattccct gagtttggta attttactct agttatatga aatattcttg tacttggaac     3480

atatgccgaa gtactaagga aggggtaagg aagcacaaag tgtgcaacaa actcaaatag     3540

ctcacaggta taagtgtaca gagaaaatga aaaaaatgtg gcaaaataat aaaaatgagg     3600

gtaaagatta cacaacagct ttcatattac tctggtaact tttctaaatt attccaaaat     3660

aaaaacgtaa acaatggctg ccaaaatgcc taacttggtg aacataagtg taattcaata     3720

tggtaaatta attcaacatg gtaaattaag agcataggcc ttaagagcca gccagcctgg     3780

ttttaaatcc tccactactt atgatctgag cttgagcaag ttacttaacc tctgcatcta     3840

tttccaccaa aggttgagag gttaagacaa gagcttagaa gagtacctgg ttataataaa     3900

cattcaaaat gttatttcaa atagattcta atttttaaat aagaggacac atgaaagcat     3960

tttgaaattt aagaatggcc ctttcccatg aagcaaggca taaggccagg ttgctaactg     4020

ttgaaagctg acagtatgtt cttgattcct gttcttgttg aagttacaca ctcaattgcc     4080

aggtattttt cttctgaatt tactatttag ccacagacta tgaaataatt ctctaaggtg     4140

accagtaaca tcagtgaaat ggaaagaaaa agttaacact tcaaactttg tgtattcacc     4200

tgaatagtca gggaactttc acctatttta tttaggtttt ctttttcttt ttttcttttt     4260

ttttcaaatt ccaaccagaa gctaaataca attggaaact ggtaagcact agttttactc     4320

caaaggagta ggatcattca gatttactcc aataaaagta tgcaaccctt aagcaaagct     4380

tttcttcatt t                                                          4391


<210> 4238
<211> 1569
<212> DNA
<213> Homo sapiens

<400> 4238
cagacgcgcg agcgcaagca gcgggttagt ggtcgcgcgc ccgacctccg cagtcccagc       60

cgaggttgat tgcactgcca acactaacac ctgtaataaa tatggagtca gtggatatcc      120

aaccctgaag atatttagag atggtgaaga agcaggtgct tatgatggac ctaggactgc      180

tgatggaatt gtcagccact tgaagaagca ggcaggacca gcttcagtgc ctctcaggac      240

tgaggaagaa tttaagaaat tcattagtga taaagatgcc tctatagtag gttttttcga      300

tgattcattc agtgaggctc actccgagtt cctaaaagca gccagcaact tgagggataa      360

ctaccgattt gcacatacga atgttgagtc tctggtgaac gagtatgatg ataatggaga      420

gggtatcatc ttatttcgtc cttcacatct cactaacaag tttgaggaca agactgtggc      480

atatacagag caaaaaatga ccagtggcaa aattaaaaag tttatccagg aaaacatttt      540

tggtatctgc cctcacatga cagaagacaa taaagatttg atacagggca aggacttact      600

tattgcttac tatgatgtgg actatgaaaa gaacgctaaa ggttccaact actggagaaa      660

cagggtaatg atggtggcaa agaaattcct ggatgctggg cacaaactca actttgctgt      720

agctagccgc aaaaccttta gccatgaact ttctgatttt ggcttggaga gcactgctgg      780

agagattcct gttgttgcta tcagaactgc taaaggagag aagtttgtca tgcaggagga      840

gttctcgcgt gatgggaagg ctctggagag gttcctgcag gattactttg atggcaatct      900

gaagagatac ctgaagtctg aacctatccc agagagcaat gatgggcctg tgaaggtagt      960

ggtagcagag aattttgatg aaatagtgaa taatgaaaat aaagatgtgc tgattgaatt     1020

ttatgcccct tggtgtggtc actgtaagaa cctggagccc aagtataaag aacttggcga     1080

gaagctcagc aaagacccaa atatcgtcat agccaagatg gatgccacag ccaatgatgt     1140

gccttctcca tatgaagtca gaggttttcc taccatatac ttctctccag ccaacaagaa     1200

gctaaatcca aagaaatatg aaggtggccg tgaattaagt gattttatta gctatctaca     1260

aagagaagct acaaaccccc ctgtaattca agaagaaaaa cccaagaaga agaagaaggc     1320

acaggaggat ctctaaagca gtagccaaac accactttgt aaaaggactc ttccatcaga     1380

gatgggaaaa ccattgggga ggactaggac ccatatggga attattacct ctcagggccg     1440

agaggacaga atggatataa tctgaatcct gttaaatttt ctctaaactg tttcttagct     1500

gcactgttta tggaaatacc aggaccagtt tatgtttgtg gttttgggaa aaattatttg     1560

tgttggggg                                                             1569


<210> 4239
<211> 3870
<212> DNA
<213> Homo sapiens

<400> 4239
aaagtacttg aatctgaaca agataaaatg agccaggggt ttcatcctga aagagacccc       60

tctgacctaa aaaaagtgaa agctgtggaa gaaaatggag aagaagctga gccagtacgt      120

aatggtgctg agagtgtttc tgagggtgaa ggaatagatg ctaattcagg ctccacagat      180

agttctggtg atggggttac atttccattt aaaccagaat cctggaagcc tactgatact      240

gaaggtaaga agcagtatga cagggagttt ctgctggact tccagttcat gcctgcctgt      300

atacaaaaac cagagggcct gcctcctatc agtgatgtgg ttcttgacaa gatcaaccaa      360

cccaaattgc caatgcgaac tctggatcct cgaattttgc ctcgaggacc agactttaca      420

ccagcctttg ctgattttgg aaggcagaca cctggtggaa gaggcgtacc tatttgcaaa      480

gtgcagagca ggcatggatt gccaattctg gaacagagca aagccccaac ttgccctcca      540

ctggtgatgt cacacccacc catgaagagc ctgcctctag ggttgttgaa tgttgggtca      600

cgaagatctc aacctggcca aagaagagaa cccagaaaga tcatcacagt ttctgtaaaa      660

gaagatgtac acctgaaaaa ggcagaaaat gcctggaagc caagccaaaa acgagacagc      720

caagccgatg atcccgaaaa cattaaaacc caggagcttt ttagaaaagt tcgaagtatc      780

ttaaataaat tgacaccaca gatgttcaat caactgatga agcaagtgtc aggacttact      840

gttgacacag aggagcggct gaaaggagtt attgacctgg tctttgagaa ggctattgat      900

gaacccagtt tctctgtggc ttacgcaaac atgtgtcgat gtctagtaac gctgaaagta      960

cccatggcag acaagcctgg taacacagtg aatttccgga agctgctact gaaccgttgc     1020

cagaaggagt ttgaaaaaga taaagcagat gatgatgtct ttgagaagaa gcagaaagaa     1080

cttgaggctg ccagtgctcc agaggagagg acaaggcttc atgatgaact ggaagaagcc     1140

aaggacaaag cccggcggag atccattggc aacatcaagt ttattggaga actctttaaa     1200

ctcaaaatgc tgactgaagc catcatgcat gactgtgtgg tgaagctgct aaagaaccat     1260

gatgaagaat ccctggagtg cctgtgtcgc ctgctcacca ccattggcaa agacttggac     1320

tttgaaaaag caaagccacg tatggaccag tactttaatc agatggagaa aattgtgaaa     1380

gaaagaaaaa cctcatctag gattcggttc atgcttcaag atgttataga cctaaggctg     1440

tgcaattggg tatctcgaag agcagatcaa gggcctaaaa ctatcgaaca gattcacaaa     1500

gaggctaaaa tagaagaaca agaagagcaa aggaaggtcc agcaactcat gaccaaagag     1560

aagagaagac caggtgtcca gagagtggac gaaggtgggt ggaacactgt acaaggggcc     1620

aagaacagtc gggtactgga cccctcaaaa ttcctaaaaa tcactaagcc tacaattgat     1680

gaaaaaattc agctggtacc taaagcacag ctaggcagct ggggaaaagg cagcagtggt     1740

ggagcaaagg caagtgagac tgatgcctta cggtcaagtg cttccagttt aaacagattc     1800

tctgccctgc aacctccagc accctcaggg tccacgccat ccacgcctgt agagtttgat     1860

tcccgaagga ccttaactag tcgtggaagt atgggcaggg agaagaatga caagcccctt     1920

ccatctgcaa cagctcggcc aaatactttc atgaggggtg gcagcagtaa agacctgcta     1980

gacaatcagt ctcaagaaga gcagcggaga gagatgctgg agaccgtgaa gcagctcaca     2040

ggaggtgtgg atgtggagag gaacagcact gaggctgagc gaaataaaac aagggagtca     2100

gcaaaaccag aaatttcagc aatgtcagct catgacaagg ctgcattatc agaagaggaa     2160

ctggagagga agtcgaaatc tatcattgat gaatttctac acattaatga ttttaaggaa     2220

gccatgcagt gtgtggaaga gctgaatgcc cagggcctac tacatgtttt tgtgagagtg     2280

ggagtggagt ccaccctgga aaggagccag atcaccaggg atcacatggg ccaattactc     2340

tatcagctgg tacagtcaga aaaactcagc aaacaggact ttttcaaagg tttttcagaa     2400

actttggaat tggcagatga catggccatt gatattcccc atatttggtt gtaccttgct     2460

gaactggtga cccccatgtt aaaagaaggt ggaatctcca tgagagaact taccatagaa     2520

tttagcaaac ctttacttcc tgttggaaga gctggggtct tgctatctga aatattgcac     2580

ctactatgca aacaaatgag ccataagaaa gtgggagcct tatggaggga ggctgacctc     2640

agctggaagg actttttacc agaaggagaa gatgtacata attttctttt ggagcagaag     2700

ttggacttca tagagtctga cagtccctgt tcctctgaag cactttcaaa gaaagaactg     2760

tctgccgaag agctgtataa gcgactcgag aaactcatta ttgaggacaa agcgaatgat     2820

gaacagatct ttgactgggt agaggctaat ctagacgaaa tccagatgag ttcacctaca     2880

ttccttagag ctttaatgac tgctgtttgt aaagcagcta ttatagccga ctcttctacc     2940

ttcagagtgg acactgctgt tatcaagcag agagtgccga tcttactcaa gtacctagac     3000

tcagatacag agaaggaact gcaagcactt tatgcactac aagcatcgat agtaaaactt     3060

gatcaacctg ccaatttgct gcggatgttt tttgattgtc tatatgacga ggaggtgatc     3120

tccgaggatg ccttctacaa atgggagagc agcaaggacc ctgcagagca gaatgggaag     3180

ggcgtggctc tgaaatctgt cacggcattc ttcacgtggc tgcgggaagc agaagaggag     3240

tctgaggata actaaaactt caaatacaca aaatgaaaca aaagaaacaa tttaagtatt     3300

tttttaaaaa gtttcacgtc ttcgccaatc acagtgcagc aaggccaatt ctcgcagaaa     3360

cccccacgtg tgcacgagtg ggagagggga aagagaaaaa aaggtgatca tggaggaaaa     3420

aggtactgga taaaagtaaa cttcaaacct tagggcggga gcactaaaac caaaatacat     3480

gtattattta tagaaaatat tttctgtttt aatcttttct ttttaaacaa ggactcatac     3540

ttaaaaaaat gtttagcaaa aaaaaaaaaa gttgagaact tttaatttat tttaaggact     3600

gcaaatgcca gtgtaatttt ttaatttgca gtttctgtaa acaacttgta taatagaaaa     3660

gcagagaaat aaatttccct ccccttcaag atgcacctca tgtttgtttt aaggtatagc     3720

atttagtcca gatttgagaa agtttggggt gaacaaggta agaaagattt tttttttttt     3780

ggcatcaaat ctttctgcct gcctctcagc ttgcttcaga aaatttaaaa aatcacaata     3840

gtaatcaaaa catacataac attgaaacag                                      3870


<210> 4240
<211> 2038
<212> DNA
<213> Homo sapiens

<400> 4240
tgttttccca aatcttttta tcgttttctt gaggtttttt tttttttaca cattctgaag       60

tcacgtttgg ttaaaatgtc gtatcaggag gaggccgaat acagggattt ttccccatgg      120

tcttacacag catatttcaa ggccagagaa tggcagggga acagaaaccc tcaagtaatc      180

tcctggagca gtttatttta ctagccaaag gtaccagtgg ctcagccctc actgctctca      240

taagccaggt cttagaggct cccggagtgt atgtctttgg agaacttctg gagctggcca      300

acgtgcagga gcttgcggaa ggagctaatg ctgcttattt gcagttgttg aacctgtttg      360

cctatgggac atacccagat tacatagtgg gtgggactga gcagccaaca aggagagcct      420

gccagaactg agcacagctc agcagaacaa gctgaagcat cttaccatcg tgagcttggc      480

atcaagaatg aagtgtatcc cctactccgt gttgctgaaa gacctggaga tgcggaatct      540

ccgggaacta gaagacctta tcattgaggc tgtctacact gacatcatcc agggcaagct      600

ggaccagcga aaccagctgc tggaagtgga tttctgcatt ggccgtgaca tccgaaagaa      660

ggatatcaat aatattgtca agaccctgca tgaatggtgt gatggctgtg aagcagttct      720

actgggcatc gagcagcaag ttctgagagc caaccagtac aaagagaacc acaaccgaac      780

tcagcagcag gtagaagcag aggttaccaa catcaagaag acactcaaag ccaccgcatc      840

ctcctcggct caggagatgg agcagcagct ggctgaacgg gagtgtcccc ctcacgctga      900

gcagaggcag cccaccaaga agatgtccaa agtgaaaggt ctggtctcca gccgccacta      960

gggccggctg gggcagctgg cactcaccag gcctgggtca ggtggggagg ggacaccaag     1020

ggcccatttc ctcccctctc tacctgcagt gagttccaga cctgcccgtc ccctcaccag     1080

cgcctcccca ccctgttggt actgttccag aaaaactgtt actccccctc acccactccc     1140

tccttcccca gttgttccct tcagactcag gggctccacc aatgccatcc caaaacaggg     1200

tcagacactg cccagcttcc ctccaggagg ttcttgtctc tgtgtaaggg cttgtctccc     1260

tcccagtttt tcttttgctc cacgtcattt tgtcaggctg gttataagcc ggaggcagct     1320

ttaaccagcc cccagggatg attgtgaagg aggcccctcc ccttgtgagg agggggcact     1380

cctctccagc ccctggtacc acagtcctca cgatggtgca gtgatttcta gccaggcgtc     1440

aagatgcgct gctttccctc tcctgcctca tcccttgttg gcagctccag ttcaggccgt     1500

ggagggacgt gatgctgggc tgtgtttact aaacccacgg gttttcagcc tcttaagccc     1560

agctccgatc tccaattagt tgagagcgct gggttgacta acctctggta tctgagcaca     1620

gacagagggt gctgtgggtc tgctgggtgg cagaaatggt tccttccggc ttggcgttct     1680

ctcctggcca ctcttcctgc tgcctctgac tactcagcct tgttttcggt gtgtaggccc     1740

cagctgccca ctggaactgc cggctaatgc ttgctctccc aagatcttta actcctcctg     1800

gctgcacctg ggtagggatg gtggcatcga tgcccctctg tctgctgaag gacctgttgc     1860

tgcttctgtc ttttcacccc tccttggctg atgacccaga gccctctgat gatggcattc     1920

tcctggcaag agaaaaagac ttaactagac ttctgaactt gaacagtttc aggttatatt     1980

ttaatttttt tttttttgta caggttctga ttctaataca tttcaacatg cttttgtc       2038


<210> 4241
<211> 1159
<212> DNA
<213> Homo sapiens

<400> 4241
gcccttcttt gttgactgag gaaagctcgc tccctgccca ggtttttcat tgttgatcga       60

aattaacacc aggtggtgaa tagagcccct cctaaggttg ctcaggataa atcatttatt      120

aaataggtct gcttatcagg aggggcgtga aggctcccaa aaggaaatgc tggcacctgg      180

gcccagaagc cagggcctct aactcctggg gttgatttct tcagtgaagt tgcaccctac      240

aaagggaata tggccaaagc ggcactcaac tgaaggctga tatcaggcga ttagacagcc      300

atgcattctg cgtttgtctg gaatggattg tagagagatg gacttatatg aggactacca      360

gtccccgttt gattttgatg caggagtgaa caaaagctat ctctacttgt ctcctagtgg      420

aaattcatct ccacccggat cacctactct tcagaaattt ggtctgctga gaacagaccc      480

agtccctgag gaaggagaag atgttgctgc cacgatcagt gccacagaga ccctctcgga      540

agaggagcag gaagagctaa gaagagaact tgcaaaggta gaagaagaaa tccagactct      600

gtctcaagtg ttagcagcaa aagagaagca tctagcagag atcaagcgga aacttggaat      660

caattctcta caggaactaa aacagaacat tgccaaaggg tggcaagacg tgacagcaac      720

atctgcttac aagaagacat ctgaaacctt atcccaggct ggacagaagg cctcagctgc      780

tttttcgtct gttggctcag tcatcaccaa aaagctggaa gatgtaaaaa actccccaac      840

ttttaaatca tttgaagaaa aggtcgaaaa cttaaagggt tctccaaaaa atgtggaatc      900

ctttgcatct atgctgagac attctcctct tacacagatg ggacctgcaa aggataaact      960

ggtcattgga cggatctttc atattgtgga gaatgatctg tacatagatt ttggtggaaa     1020

gtttcattgt gtatgtagaa gaccagaagt ggatggagag agtcccattt cgtggtatgc     1080

tgtttggagg agattttcac aagtgatgat aacctgtttt tcttccaact ctgactttgg     1140

aaaacatcgt aaaagataa                                                  1159


<210> 4242
<211> 3507
<212> DNA
<213> Homo sapiens

<400> 4242
agtgctcagc aacgattacg ccccgagggc caatcacagg gctgcggccg agagagaagc       60

cttattagag ctttctcaac ctgcagccct catctccgcc ggcgagtagg gccaggtgtt      120

gggagctccc acgtgggaca agatggtgtc ttcggcgcag atgggcttca acctgcaggc      180

tctcctggag cagctcagcc aggatgagtt gagcaagttc aagtatctga tcacgacctt      240

ctccctggca cacgagctcc agaagatccc ccacaaggag gtagacaagg ctgatgggaa      300

gcaactggta gaaatcctca ccacccattg tgacagctac tgggtggaga tggcgagcct      360

ccaggtcttt gaaaagatgc accgaatgga tctgtctgag agagcaaagg atgaagtcag      420

agaagcagct ttgaaatcct ttaataaaag gaagcctcta tcattaggga taacacggaa      480

agaacgacca cctctagacg tggacgaaat gctggagcgc ttcaaaacag aagcacaaga      540

caaagacaat aggtgcaggt atatattgaa gacgaagttc cgggagatgt ggaagagctg      600

gcctggagat agcaaagagg tccaggttat ggctgagaga tacaagatgc tgatcccatt      660

cagcaacccc agggtgcttc ccgggccctt ctcatacacg gtggtgctgt atggtcctgc      720

aggccttggg aaaaccacgc tggcccagaa actaatgcta gactgggcag aggacaacct      780

catccacaaa ttcaaatatg cgttctacct cagctgcagg gagctcagcc gcctgggccc      840

gtgcagtttt gcagagctgg tcttcaggga ctggcctgaa ttgcaggatg acattccaca      900

catcctagcc caagcacgga aaatcttgtt cgtgattgac ggctttgatg agctgggagc      960

cgcacctggg gcgctgatcg aggacatctg cggggactgg gagaagaaga agccggtgcc     1020

cgtcctcctg gggagtttgc tgaacagggt gatgttaccc aaggccgccc tgctggtcac     1080

cacgcggccc agggccctga gggacctccg gatcctggcg gaggagccga tctacataag     1140

ggtggagggc ttcctggagg aggacaggag ggcctatttc ctgagacact ttggagacga     1200

ggaccaagcc atgcgtgcct ttgagctaat gaggagcaac gcggccctgt tccagctggg     1260

ctcggccccc gcggtgtgct ggatcgtgtg cacgactctg aagctgcaga tggagaaggg     1320

ggaggacccg gtccccacct gcctcacccg cacggggctg ttcctgcgtt tcctctgcag     1380

ccggttcccg cagggcgcac agctgcgggg cgcgctgcgg acgctgagcc tcctggccgc     1440

gcagggcctg tgggcgcaga cgtccgtgct tcaccgagag gatctggaaa ggctcggggt     1500

gcaggagtcc gacctccgtc tgttcctgga cggagacatc ctccgccagg acagagtctc     1560

caaaggctgc tactccttca tccacctcag cttccagcag tttctcactg ccctgttcta     1620

caccctggag aaggaggagg aagaggatag ggacggccac acctgggaca ttggggacgt     1680

acagaagctg ctttccggag tagaaagact caggaacccc gacctgatcc aagcaggcta     1740

ctactccttt ggcctcgcta acgagaagag agccaaggag ttggaggcca cttttggctg     1800

ccggatgtca ccggacatca aacaggaatt gctgcgatgc gacataagtt gtaagggtgg     1860

acattcaacg gtgacagacc tgcaggagct cctcggctgt ctgtacgagt ctcaggagga     1920

ggagctggtg aaggaggtga tggctcagtt caaagaaata tccctgcact taaatgcagt     1980

agacgttgtg ccatcttcat tctgcgtcaa gcactgtcga aacctgcaga aaatgtcact     2040

gcaggtaata aaggagaatc tcccggagaa tgtcactgcg tctgaatcag acgccgaggt     2100

tgagagatcc caggatgatc agcacatgct tcctttctgg acggaccttt gttccatatt     2160

tggatcaaat aaggatctga tgggtctagc aatcaatgat agctttctca gtgcctccct     2220

agtaaggatc ctgtgtgaac aaatagcctc tgacacctgt catctccaga gagtggtgtt     2280

caaaaacatt tccccagctg atgctcatcg gaacctctgc ctagctcttc gaggtcacaa     2340

gactgtaacg tatctgaccc ttcaaggcaa tgaccaggat gatatgtttc ccgcattgtg     2400

tgaggtcttg agacatccag aatgtaacct gcgatatctc gggttggtgt cttgttccgc     2460

taccactcag cagtgggctg atctctcctt ggcccttgaa gtcaaccagt ccctgacgtg     2520

cgtaaacctc tccgacaatg agcttctgga tgagggtgct aagttgctgt acacaacttt     2580

gagacacccc aagtgctttc tgcagaggtt gtcgttggaa aactgtcacc ttacagaagc     2640

caattgcaag gaccttgctg ctgtgttggt tgtcagccgg gagctgacac acctgtgctt     2700

ggccaagaac cccattggga atacaggggt gaagtttctg tgtgagggct tgaggtaccc     2760

cgagtgtaaa ctgcagacct tggtgctttg gaactgcgac ataactagcg atggctgctg     2820

cgatctcaca aagcttctcc aagaaaaatc aagcctgttg tgtttggatc tggggctgaa     2880

tcacatagga gttaagggaa tgaagttcct gtgtgaggct ttgaggaaac cactgtgcaa     2940

cttgagatgt ctgtggttgt ggggatgttc catccctccg ttcagttgtg aagacctctg     3000

ctctgccctc agctgcaacc agagcctcgt cactctggac ctgggtcaga atcccttggg     3060

gtctagtgga gtgaagatgc tgtttgaaac cttgacatgt tccagtggca ccctccggac     3120

actcaggttg aaaatcgatg actttaatga tgaactcaat aagctgctgg aagaaataga     3180

agaaaaaaac ccacaactga ttattgatac tgagaaacat catccctggg cagaaaggcc     3240

ttcttctcat gacttcatga tctgaatccc cccgagtcat tcattctcca tgaagtcatc     3300

gattttccag gtgttggtga actgcctgtg actcctctcc tccccggccc ctacccctca     3360

gggataatga gttcattgct gggctagatg ttttagccat gattctgcct ctgttttata     3420

cctgcacaca tccttatctt tgttacatat gaaatatctg tatcacgggt atattgagag     3480

aaataaaggt gagagcattc acaaatg                                         3507


<210> 4243
<211> 2249
<212> DNA
<213> Homo sapiens

<400> 4243
gagagaggaa gtgatcgctc ccggaggagc gcgagccgag cggccggcgc agcgtgagac       60

agcacatcct gcccgcgccg gccccgccac cttcgggagc cgcctgcacc aacgctgccg      120

ccgcccagga gccgccgccg gctcggggag cccagttccg ccgctgccga gcgcgtccag      180

gaaaccaaca tgtctgacaa aagtgactta aaagctgagc tagagcgcaa aaagcagcgc      240

ttagcacaga taagagaaga gaagaaacgg aaggaagagg agaggaaaaa gaaagaggct      300

gatatgcagc agaagaaaga acccgttcag gacgactctg atctggatcg caaacgacga      360

gagacagagg ctttgctgca aagcattggt atctcaccgg agccgcctct agtcccaacc      420

cctatgtctc cctcctcgaa atcagtgagc actcccagtg aagctggaag ccaagactca      480

ggcgatctgg ggccattaac aagaagaaga ctgcataaac tgggcgtgtc aaaggtcacc      540

caagtggatt tcctgccaag ggaagtagtg tcctactcaa aggagaccca gactcctctt      600

gccacgcatc agtctgaaga ggatgaggaa gatgaggaaa tggtggaatc taaagttggc      660

caggactcag aactggaaaa tcaggacaaa aaacaggaag tgaaggaagc ccctccaaga      720

gagttgacag aggaagaaaa acagcagatc cttcattcag aggaatttct catctttttt      780

gaccggacaa tacgggtaat tgaaagagcc ctggctgaag attccgacat cttttttgac      840

tacagcggcc gagagttaga ggaaaaagat ggggatgttc aggctggagc caatctttct      900

ttcaatcgtc agttctatga tgaacattgg tccaagcatc gagtggtcac ttgtatggac      960

tggtccctcc agtaccctga gctgatggtg gcttcttaca acaacaatga agatgctccc     1020

catgaaccag atggagtggc cttggtttgg aacatgaagt ttaagaaaac cacaccagaa     1080

tacgtcttcc actgtcagtc ctctgtgatg tcggtctgct tcgcccgttt ccatcctaac     1140

ttggtggttg gtgggactta ctcgggccag attgtcctct gggacaatcg cagtcatcga     1200

aggactccag tgcagcggac acccttatca gctgctgcac acacgcatcc cgtgtactgt     1260

gtaaatgttg ttgggaccca gaatgctcat aacctcatca ctgtctccac tgatggcaaa     1320

atgtgttcct ggagcctgga catgctctca actccacagg agagcatgga gctggtgtac     1380

aataagtcca agcctgtcgc tgttaccgga atggctttcc caacgggaga cgtcaataac     1440

ttcgtggttg gcagtgagga aggtacagtc tacacggctt gtcgtcatgg aagcaaagca     1500

ggtattggtg aggtctttga aggtcaccaa gggccagtga caggaattaa ctgccacatg     1560

gcagtgggcc caatcgactt ttctcacctg tttgtcacat catcatttga ctggactgtc     1620

aaactgtgga ccaccaagca caacaagccg ctctactcct ttgaagacaa tgcagactat     1680

gtgtacgatg tcatgtggtc ccccgtgcat cctgcgcttt ttgcctgcgt ggacgggatg     1740

gggcgcttgg acctctggaa cctcaacaat gacaccgagg ttccaacagc aagtgtggcc     1800

attgaggggg catccgccct aaaccgtgtt cgttgggccc aagctggcaa agaagttgct     1860

gttggggact cggaaggccg tatttgggtc tatgacgttg gagagggtct tgctatgttg     1920

ccaggctggt ctcaaaattc ctggactcaa gcaatcctcc tatgttggcc tcccaaagtg     1980

ctgggattac agacatgagc cactgtgccc agctatgcct gcttgttata tcagctactg     2040

agagatgagt accaaaatct ggaagtataa ttgtggatat cttttagttc tttcagttct     2100

atcagctttt gttttctgta tccaaagctt tgttattagg tgcctacata ttgaggattt     2160

catgtgtttg cgatgaactg acccttttat caatatgaaa tgttgctgtt tattcctagt     2220

aataatcctt tttcttaaat ctactttga                                       2249


<210> 4244
<211> 9312
<212> DNA
<213> Homo sapiens

<400> 4244
gtgctgtggc ggcggcggcg gcggtagtgg cggcggcggc ggtgcctggg cggcagcagc       60

agcagtagcg gcagccctga ggacggtgag acggccgcgg cggcggcgac agcgcggaag      120

tcgcgcggga cccagagctt cccccctgtc gctagtgctg aggctttcgc ctttcctacc      180

cagcttcttg ctcacggccc gggctgggct gggcagggca acgcgccccc ggggaggggc      240

ggagctgtag atatggtgta agatacttct tcaagattgg acagctgggg accttcttct      300

gattaacctt aaaccaactt gtagccatag agacacctca caaggttccc atttttgttg      360

ttgttgttgt tgattttctg ctcacacctt tcctgacctt gcaaccatgt atggaagtgc      420

ccgctctgtt gggaaggtgg agccgagcag ccagagccct gggcgttcac ccaggcttcc      480

acgttcccct cgcttgggtc accgtcgaac caacagtacg ggagggagtt cgggaagcag      540

tgttggaggt ggcagtggga aaaccctttc aatggaaaat atacaatctt taaatgctgc      600

ctatgccacc tctggcccta tgtatctaag tgaccatgaa aatgtgggtt cagaaacacc      660

taaaagcacc atgacacttg gccgttctgg gggacgtctg ccttacggtg ttcggatgac      720

tgctatgggt agtagcccca atatagctag cagtggggtt gctagtgaca ccatagcatt      780

tggagagcat cacctccctc ctgtgagtat ggcatccact gtacctcact cccttcgtca      840

ggcgagagat aacacaatca tggatctgca gacacagctg aaggaagtat taagagaaaa      900

tgatctcttg cggaaggatg tggaagtaaa ggagagcaaa ttgagttctt caatgaatag      960

catcaagacc ttctggagcc cagagctgaa gaaggaacga gccctgagaa aagatgaagc     1020

ttccaaaatc accatttgga aggaacagta cagagttgta caggaggaaa accagcacat     1080

gcagatgaca atccaggctc tccaggatga attgcggatc cagagggacc tgaatcagct     1140

gtttcagcag gatagtagca gcaggactgg cgaaccttgt gtagcagagc tgacagagga     1200

gaactttcag aggcttcatg ctgagcatga gcggcaggcc aaagagctgt ttcttcttcg     1260

aaagacattg gaggaaatgg agctgcgtat tgagactcaa aagcagaccc taaatgctcg     1320

ggatgaatcc attaagaagc ttctggaaat gttgcagagc aaaggacttt ctgccaaggc     1380

taccgaggaa gaccatgaga gaacaagacg actggcagag gcagagatgc acgttcatca     1440

cctagaaagc cttttggagc agaaggaaaa agagaacagt atgttgagag aggagatgca     1500

tcgaaggttt gagaatgctc ctgattctgc caaaacaaaa gctctgcaaa ctgttattga     1560

gatgaaggat tcaaaaattt cctctatgga gcgtgggctt cgagacctgg aagaggaaat     1620

tcagatgctg aaatcgaatg gtgctttgag tactgaggaa agggaagaag aaatgaagca     1680

aatggaagtg tatcggagcc attctaaatt tatgaaaaat aagattggcc aggtgaaaca     1740

ggagctgtcc agaaaggaca cagaactact cgccctgcag acaaagctag aaacactcac     1800

aaaccagttc tcagatagta aacagcacat tgaagtgttg aaggagtcct tgactgctaa     1860

ggagcagagg gctgccatcc tgcagactga ggtggatgct ctccgattgc gtttggaaga     1920

gaaggaaacc atgttgaata aaaagacaaa acaaattcag gatatggctg aagagaaggg     1980

gacacaagct ggagagatac atgacctcaa ggacatgttg gatgtgaagg agcggaaggt     2040

taatgttctt cagaagaaga ttgaaaatct tcaagagcag cttagagaca aggaaaagca     2100

gatgagcagc ttgaaagaac gggtcaaatc cttgcaggct gacaccacca acactgacac     2160

tgccttgaca actttggagg aggcccttgc agagaaagag cggacaattg aacgcttaaa     2220

ggagcagagg gacagagatg agcgagagaa gcaagaggaa attgataact acaaaaaaga     2280

tcttaaagac ttgaaggaaa aagtcagcct gttgcaaggc gacctttcag agaaagaggc     2340

ttcacttttg gatctgaaag agcatgcttc ttctctggca tcctcaggac tgaaaaagga     2400

ctcacggctt aagacactag agattgcttt ggagcagaag aaggaggagt gtctgaaaat     2460

ggaatcacaa ttgaaaaagg cacatgaggc agcattggaa gccagagcca gtccagagat     2520

gagtgaccga atacagcact tggagagaga gatcaccagg tacaaagatg aatctagcaa     2580

ggcccaggca gaagttgatc gactcttaga aatcttgaag gaggtggaaa atgagaagaa     2640

tgacaaagat aagaagatag ctgagttgga aagccttttt tctaggcaag tgaaagacca     2700

gaataagaag gtagcaaatc tgaagcacaa ggaacaggtg gaaaaaaaga agagtgcaca     2760

aatgttagag gaggcgcgac gacgggagga caatctcaac gacagctctc agcagctaca     2820

ggtggaggag ttactgatgg ccatggagaa ggtaaagcag gaactagaat ccatgaaagc     2880

aaagctgtcc tccacccagc agtctctggc agaaaaggaa actcacttga ctaatcttcg     2940

ggcagagaga aggaaacact tagaggaagt tctggagatg aagcaagaag ctcttctggc     3000

tgccattagt gaaaaagacg ccaatatagc tctcttggag ctttcgtcct ctaagaagaa     3060

gacccaagag gaagtggctg ccctgaagcg ggagaaggat cgtctggtac agcagcttaa     3120

gcagcagacg caaaatcgaa tgaagctaat ggccgacaac tacgaggatg accacttcaa     3180

atcctcccat tccaatcaaa caaatcacaa gccctcccca gaccaggatg aggaggaggg     3240

tatatgggca tagccaatca gaggcttagt tcagccattt tgttcagaac gatcatccag     3300

cccctcttag aacttgacca aaatagaagt aaattaaagt tgtacattgg acacctgaca     3360

accctctgcc atgaccgaga ccccctgatc ctccgtggac tcactccacc agcttcctat     3420

aacttggacg atgaccaggc ggcttgggag aatgagctgc agaagatgac ccgggggcag     3480

cttcaggatg agttagagaa aggtgaacgg gacaatgcag aactgcagga gtttgccaac     3540

gccattcttc agcagatagc agaccattgt cccgacatcc tagagcaagt ggtcaacgcc     3600

ctggaagagt cctcttgacc ctgctttatg gggaagcctg aggtagtcaa cccaggagcc     3660

aagaaaagag aactacgagg aacaggtgcc cggaaccttc ttggcaccaa acactacaaa     3720

cttcatccca acttgctcac ttgaagaagt gtgattccag caccgtttct acatctgcca     3780

tcttactctg cctttctgct ttggatgtgg tctctacact aaccttcttg atgtccaggg     3840

tagataaagg gtcgaatctc tctgaagaac tgccacctgg tcatcagcag tggagaactg     3900

tgggagctgg tggctctgcc ctgacagaga gccatggagc agaggagcct ctcacctcct     3960

gtcctctgac atgagaatga aaccaggaat ggacttggag ttcaacaggc tgagaggatg     4020

cctccaatgg accagagagc tgagtgttct aatatcacaa taggtgcttt ctcctaaaag     4080

ggcaaaaaac aatctcaaaa agattagaaa aagagaaggg gggaagggaa gagaaaatcg     4140

actcttcttt ttactgtctc ttctgcttac tttccacatg agatgctttg taccggggag     4200

ctgtgagcag gcctcacgat ggcttgggag cactcgttct cccaaggtct gagtcttcat     4260

ccagccctgc ctgtctgtcg cagccttcct cactctgttc ctcggccagt taacaagaag     4320

atggtgtgag gtgttctcca ccagtctctc ctgtttgaga ctgttgacgt tatcatactg     4380

aggtgttaga tcaaatatct ctaattgaag aacatgtgag gttgaaagag caccagccag     4440

ggcaacatag cgtgaccctg tctctacaaa aaattaaaaa gagaacatac aaagttgaca     4500

tatgagaccc tgttgtcccc gcctgcagct ttgccccagt aacagatgcc cgttgctctt     4560

gggctggttt cccctgaaca cctccaagag gctgcctgcc ttgccagcac ccgtgtcctg     4620

agctcctgca gcccagtggc tgctgaagtt gtgatccctc actcaccctg ctagctttgc     4680

ccttgactcg tcttctctga acctcagcct cgtgcattgc ctggaacctt cttctagcat     4740

aaatgaaggt ttttcctcct acacacattc cttcctcggt tatttcattc agagaatatt     4800

tatgaaatgc ctactgtgtg caagtcatcc atccttgaaa aggccacttc tcagtgaggg     4860

agagatgtag tggattctgt gagacatacc tgctggagtt gaagcagtaa atagcatgtc     4920

cttcccctcc ccgatcttaa ggtgtgtttt ctagaaaagt tccctaatgg aattcatgag     4980

tttgggggtc tcagtcaccc gcttgcctgt aggattccat ttgatgattc tggatttttg     5040

ctgtttgtta ttgcccttag aggggctctg agtatctact tgtgggtggc catttcctga     5100

catctgcatg tacctcgtgg aattcagcca gcttcatgtt gcaaatcaga aagctgaccc     5160

caagactgca aatcaatgaa ggtattggca ttgttaagga cgtagcgtag acaacagcag     5220

tcataaataa ttaggcagga acttaaccca aatctagttc tttgaccacc tctaccacca     5280

gaacccagca gacactcaca tctcctgata agagttgctg gactcgatgt ttttgttttg     5340

cattttctcc tctccttccc cacttactca gagaatttaa agtctgtaga gtcagcacag     5400

ccccatcagt ccaggaactt cccaccacca gcccttgact gtcccattaa ctgacatggt     5460

cagatttcca gctcccccta ctccctgctg tgaaacaatc cctctccctg tgagaggaaa     5520

ctgtggagcg tttcttatcg aaggttaaat ggactctgct cataaacctc ttactgagat     5580

gcttcctgat agccaggctg gccagagagg ggtgcagggg ttagatagta agtggtggtc     5640

gtttgtggtc agttacctca attctgttca ttgcagtgcc cgtaaaccat gtagaaagct     5700

cccagcactg aaaggcagga gtgttagcat ctcgctttat ccaccataac gtaaagaact     5760

gcggtgtgat aacagccttc acggggccac ggtggaacca agacagcagg cgaggccatg     5820

cctaaacaag tggtctggca cgggcactgg ccagctgctc tctccaagca ggtggcccag     5880

atcccaccca cgtggacttt ctcatcaggt gcagcgcctg ccactctcag ccactgggtg     5940

tgtcactctc ctcttcatct cagcattctc catcacttcc cctccagaaa aacggatgga     6000

aggaagccct ctgtgacact gcttctgaga agaagcattt ccgggaccga tatcatctgt     6060

ctggtctctg tgaacagcaa ggaatcttct tgaccgttct tgggcactgg aggctggcta     6120

ggagttcagt aataaacgtg gccttcgtgc tgtagggcag agtggatgca gtttgtagct     6180

ttcagagtgt ctcattgagt ctagatcatt gaaccaacac ttaaccaaat gtcccactcc     6240

catcacacta ggacttgtca ttccatgccc ctctcctagt ggtcatggtt tcatatgggc     6300

atacaactgc tactgaagtt atatagcctt gaaaactcag tgcaggttgc ccttaatttt     6360

ccccaaaccc ctccatcggc aagtctagtt gccctttagc acctaaagat ctgcacccca     6420

aaccaatgtc accataaaga gggcacgaag aagagtgggt gtgatcccaa cggggttttg     6480

taactgaaga agcccagtgt gagcttctca tcttttcata tacctctaac ccccggtact     6540

cattgaatca ttgatgaggt atctcaattg agatttgcaa ggactttgat accatttgaa     6600

atggaaaaat tttgaacggg ctttaacatg tttaagaaat atggatgggg ccggccacag     6660

tggctcacgc ctgtaatccc agaactctgg aaggctgagg caggcggatc acctgagatc     6720

aggagttcga ggccagcctg gccaagatgg caaaaacccc gactctacta aaaatacaaa     6780

attagccagg cgtggtggcg tacgcctgta atcccagcta ctcaggaggc aggagaatcg     6840

cttgagcctg ggaggcagag gctgcggtga gccgagatcg tgtcactgca ctccagcctg     6900

ggtgacagag actccattta aaaaaaaaaa aaaaaaatat atatatatat atatatatat     6960

atatatggat gggaatcacc aaattcatct cagctctaac cttttaacct ttgtccttgc     7020

actttacaat ctaaagatct acctgtggct ctcagacttc ctcacacttg ggttttagaa     7080

ataacttgta aagcagactg gacccaaggc cgccttcagt gtcaagaagg gcattgtgac     7140

ttgcccctca atttctgtcc attgaagtct ggttttccat gaggaacttg cgggctcacc     7200

cacccccaga gtgagagaag aggaaggcga agtcatcaca gacacggtct tagccacctg     7260

ctgaactaat ccctccgcta ttgagggtca gggttgtgag gcaaccatca tgtgtcaccc     7320

caaaatataa atgtttctga gccgcccatc cactggcatt tggatttgct gccagagtcc     7380

tgttcctccc agaaccatcc cgccctcctg ttgaccatgt tacttgagtg taggcccggt     7440

gtcaagaccc tcagagtctt tgaggaaaga gccaagcaga gaagaccgct gcgtggagtg     7500

tgacaccaca tggcatttct caagcccagc ggaccctgtg tcagcaaata ccagtaattt     7560

aacatctgct cctggcctcc tcttcacctg cctgggttcg gaactgagga ggaaggatga     7620

gaagagactg caatgcagca ggcaccctct gcagagtgag gccgcccgtc catcactgcc     7680

agccctgggc tgctcaggag gggacgtgaa ccactcaaag gaatgtctta aagaggatct     7740

ggagtttccc ccatgcaaat tagggaagaa ttaggcaaga aaagacatac attacaggga     7800

aatccttctg aacaaaatgg ctgtcttcac ctactcttct tgcaagaaaa gacatacatt     7860

acagggaaat ccttctgaac aaaatggcta tcttcaccta ctcttcagca aaaaccgtct     7920

ccagactttt tagtgtcaaa aatgtaacca actgtctcct gattttttcc aatgtgtttg     7980

gcaagtgctg tggccctgtt gtaggtactt ctcctgactc ttgggggaga agtggtttta     8040

gggattgatt tgggggagcg ggtttttgtc ccatcccacc tcctctcttc tttctctgct     8100

tgtcgatatt gtctgtgtga ttcagagaat tggggcagtt acattgtgtc tgttgttgag     8160

attattaaaa gattaaaacg tagttgtaga aatgaaaaat taaacagctg tgttttaaaa     8220

atgcaaacca atatcttgtt aataaaggaa ttcaagctat ggggcagcca cactcccctc     8280

ctcccaggct ggcataggtg gccctgggct ggcggcttag gaagcatgga gcacacttag     8340

ggtagtgcct gcctgggcaa gagacacctg ccgagcaaaa ggaacgagaa tctggggctc     8400

agagcctcgc agttgtgcca ggattttcct atacatgttc aggacctctg ggtagaggtt     8460

tcacagtttg tgaccccata accaccctca cccgacgtgg gttctagctc agtgtgccta     8520

atactgcatg gtaacctggg cttgaccctg aagcccctgc ctggcaggcc acaggacctc     8580

tcctgcccac ttggtgctat ctcttccagt gaccacccag cacgggtgag cactggccag     8640

cctggagcct gcaatccagg tggaacagac tgtcctccat gtcagttcct tctggcttca     8700

ggccctcaat tatttccctt tgagcttttt tagaccctag atctcctagg cccaggctct     8760

ctcttgaccc cagagaagcc actgtcagga aaggaagtga accctactga agccagagaa     8820

ttcaccccgg ccaaagcagg ccctctgggt ccagcccctc attccacacc acgccagtat     8880

tgcatccatc tactgcagct acacatcctg agggcagcac cacccactct ggcctgctgg     8940

cccatcgcag gactagccca ggcacctgcc gggcattgca ggatatccag tggggcctgt     9000

gactgctccc tgatgcgtca gaagagaagt gttgcacttt agtggaggag ctgaggagca     9060

cctgccccct tgtagcttga gttccttttg gtaacagtag cagcctccat ggtggtgtct     9120

gggatgcacg tgcacccgct gccttcagct gtatgtgtgt gttcctgctg gagttgtgtt     9180

actgacagga taatgacatt acaaagaaat tgtgttatat tcaactttgc cttgataatt     9240

attgtaaaca ctttgttcat tttttctttt ttattcacaa actaaatcca ccaggaaatt     9300

ataaagttat tt                                                         9312


<210> 4245
<211> 2847
<212> DNA
<213> Homo sapiens

<400> 4245
ggtttgcgac tgggagagga aatctgtgtc ctggacaaga ttggattatg gaagtgggaa       60

gtgaagaaga aaaatgggag aagctggatg cagaatttga tcactttgtg gttgatatga      120

agccctttgt tctaaaatta cctcatagga cagaacggca gaggtgtgct ctttggatta      180

gaaagctgtg cgaaccttca ggaacaggtg caggaataat ggggaggaag aatcggaacc      240

tgtatgcaaa attgttattg catatgctta aacgaggtgc gcttgaaggc ccttttacac      300

accgacctga acccgggaca ctaaaaattc taccttcata catgtccatc tattttgatg      360

aaccaaatcc agcacgagca aaaggttcaa gcccagaggg attaccagcc tgggtactgg      420

gtgagctgga gacaagtgaa cacaaattaa atgaatcatg gaaactctct tctggagaag      480

ataacacttt agtacagtcg ccaactgatg tctacagcag ggaacagtac actgggaagc      540

tccgagtgag atcacactcc ttgagtccaa ctcacagaga agatggacaa aatattaccc      600

caaagatttg tgaagtttat tcgaaaaaat ctcctgtttc tttggatgat agtgacattg      660

aagctcgcct taatagttgg aatcttgggc tggacatgaa aacaaaaatg atggaagcta      720

aatttcatga agaaaagctt aaactgcaac agaaacatga tgctgatgtt cagaagattt      780

tagaaagaaa gaataatgaa atagaagaac tgaaaacttt atacaggagt aaacaacatg      840

aaactgaaga gactattaga aagcttgaaa agaaagttca gacactgata cgtgactgtc      900

aagttatcag agagactaaa gaagaccaga ttgcagagct gaaaaagata tgtgaacaaa      960

gtacggaatc tctaaataat gactgggaaa aaaagcttca caatgctgta gcagaaatgg     1020

aacaggaaaa gtttgatctt caaaagcaac acactgaaaa cattcaagaa ttgcttgagg     1080

atacaaatgt gcgtctgaat aaaatggaga gtgaatacat ggcgcaaaca cagtccacaa     1140

accacatgat caaagaactg gaggcccgtg tccagcagct gactggagaa gcagagaaca     1200

gtaatttaca gaggcagaaa ttaattcaag aaaaagcaga acttgaaaga tgttaccaga     1260

taacgtgtag tgaattacaa gaagtaaagg caaggcgtaa cacactgcat aaagagaagg     1320

accatcttgt aaatgattat gagcaaaaca tgaaactgtt acaaaccaaa tatgatgctg     1380

atataaacct tctaaaacaa gaacatgctc tttcagcttc taaggcatct agtatgattg     1440

aagaattaga gcagaatgtc tgtcaattaa aacagcagtt acaggaatca gaacttcaaa     1500

gaaagcaaca actaagggat caagaaaata agtttcagat ggagaaaagt catttaaaac     1560

acatctatga aaaaaaggct catgacttgc agagtgaact tgataaagga aaagaagata     1620

ctcaaaagaa aattcataaa tttgaggaag ctttgaagga aaaagaggag cagctaactc     1680

gtgtgactga agttcagagg ttgcaggccc agcaggcaga tgccgctctg gaagagttta     1740

agcggcaggt ggaactgaac tcagagaaag tctatgctga aatgaaagag cagatggaaa     1800

aagtggaggc agatctaact agatccaaat ctcttcgtga gaaacaatca aaggagtttt     1860

tatggcaact ggaggacatc agacagcggt atgaacaaca gatagtagag ctgaagctgg     1920

agcatgaaca ggagaagacg cacctattac agcagcataa cgcagagaag gatagcctag     1980

tccgagacca tgaacgggaa attgaaaacc tggaaaaaca gcttcgcgct gccaatatgg     2040

agcacgaaaa tcaaattcag gagttcaaga aacgagatgc acaggttatt gccgacatgg     2100

aggcccaggt tcacaagttg agagaagaat tgatcaatgt gaactcacag cggaaacagc     2160

agctggtaga gcttggtctt cttcgtgaag aggaaaagca aagggctaca agggaacatg     2220

agattgtcgt caataaactg aaggctgaat cagaaaagat gaaaatagag ctgaaaaaga     2280

ctcatgctgc tgagacagag atgacactgg aaaaggccaa cagcaagctg aagcagattg     2340

agaaggaata cactcagaag cttgccaaat cttcacagat catagcagaa cttcagacaa     2400

ccatttcctc tctgaaagaa gagaacagcc agcagcagct tgctgcagaa aggcggctcc     2460

aggatgttag acaaaagttt gaagatgaga agaagcagct gattagagat aatgaccaag     2520

caatcaaggt tttacaagat gaattagaaa accgttctaa tcaggtgcga tgtgcagaga     2580

aaaaattaca acacaaagaa ttggagtcac aggaacagat aacttacata cgacaagaat     2640

atgaaacaaa attgaaagga ttgatgccag catccctaag acaagaactt gaagacacca     2700

tttcctccct aaaatcacag gttaattttc tgcaaaagag agcttccatc cttcaggaag     2760

aactgactac atatcaaggc agaaggtaac tgcacgagag aatgcaacgg atgcaatttc     2820

caggctgtgc tgtggacttc ttccagc                                         2847


<210> 4246
<211> 1049
<212> DNA
<213> Homo sapiens

<400> 4246
gctactgtca catttcagtg atgtcacagc tgcaggtggt acagagccag caccaccatc       60

tgatgcccag cctgagtgct ggctgaactg agaggaacag ggttggtgcc tggcactggt      120

gttgctccat tcatctctga ggtctcacag ccccagcatg agtccatcag caaagaagag      180

gcccaagaac agcagggttt ccaagatgca agatgagaaa ctgcgggacg agacagagca      240

gcctgtgagc aaagtaattg agcggaaccg tctgagaacg gtgttaaaaa acttgtcgct      300

cttgaagcta ctcaagagct caaaccgccg gatccaagaa ctgcataagc tggccaaaag      360

gtgttggcat tcactgctca gtgttccaaa gattctccgc atctcctctg gggaaaacag      420

tgcctgcaat aaaacaaaac aaaataatga agagttccag gagatcgggt gctccgagaa      480

ggaactcaag tccaagaaat tagagtccac aggggaccct aagaaaaaag agtacaagga      540

gtggaagtcc caggtgcagt cagggatgag gaacaaggag aaaacgtcat tggcggcaat      600

gccacggaaa gaaaagcata tagagcctga ggttccaagg acatcgaggg atgatagctt      660

gaaccctgga gtccagggga ggcaaccact caccgagggc ccccgagtca tcttcattaa      720

gccctaccgc aatagaactc ccatggggca catgaagcag ctggatgtag ccgaccagtg      780

gatctggttt gaggggctgc ccacacgaat ccacctcccg gcgcccaggg tgatgtgcag      840

atcctccacc ctgcgttggg tcaagcgccg ctgcacccgc ttctgctccg catcacttga      900

aatgcctatg tggcatccat acaaggttga tgtgacctgg acgagagcca gaggtgcgag      960

cagagggtgg agatcgcgcc atcagctgaa ggggaggaat gggtggcgaa attcacgagt     1020

ctacaaataa gatcttccat atggcacct                                       1049


<210> 4247
<211> 619
<212> DNA
<213> Homo sapiens

<400> 4247
aaataattca caagttggcc atgcagctga gacacattgg ggacaacatt gatcatagga       60

tggttcgaga ggatcttcaa caggatggca gagatgcact agatcatttt gtcttctttt      120

tctttagaag agttcaggtg ttgctgcatt ttttctggaa caaccatttg ctgtaaaagg      180

aatgaaagag aacctcgtcc tcaaactaaa ggccacagaa atgggcacta cctcctggcc      240

cactccctgg gcaccatgcc ctctggtgac ctgttggctc cactcttgtc actcatgtcc      300

agatctgcag tgccagcttc tccttctcgg tgacatgtca cctccctgcc ccaatcctgg      360

ctccaaccct ctctggaaaa tcgaagtgaa acatttgtct ctaatactca aattcaacat      420

atggctcatc tcatctacct tcccatttcc atgcctagag gccccactac taccactagc      480

accgttgggt gtttccttct caggctctga ttctacaaca tttacgttct tttctcacct      540

ttgatcccct cactcctctg tgaccccctt caagtcttcc ttcaccactc cagtgttttc      600

ccataccact cgaccctgc                                                   619


<210> 4248
<211> 887
<212> DNA
<213> Homo sapiens

<400> 4248
aatcggctag gagcagcgag cggcgcggct gaggcgcggc ggccccgtgg agcagcgcag       60

tatggcgggc ggggcccggg aggtgctcac actgcagttg ggacattttg ccggtttcgt      120

gggcgcgcac tggtggaacc agcaggatgc tgcgctgggc cgagcgaccg attccaagga      180

gcccccggga gagctgtgcc ccgacgtcct gtatcgtacg ggccggacgc tgcacggcca      240

ggagacctac acgccgcgac tcatcctcat ggatctgaag ggtagtttga gctccctaaa      300

agaggaaggt ggactctaca gggacaaaca gttggatgct gcaatagcat ggcaggggaa      360

gctcaccaca cacaaagagg aactctatcc caagaaccct tatctccaag actttctgag      420

tgcagaggtg agggcctctg tcctgaactt tttaacccgg tgccacaacc tgagggtctc      480

cataggggca gggagtgctg agtagtgatg gtgtctggag ggtcaaatcc attcccaatg      540

gcaaaggttc ctcaccactc cccaccgcta caactccaaa accacttatc cctacagagg      600

ccagcatcag ggtctggtca gacttcctca gagtccatct ccatccccgg agcatctgta      660

tgattcagaa gtacaaccac gatggggaag caggtcggct ggaggctttt ggccaagggg      720

aaagtgtcct aaaggaaccc aagtaccagg aagagctgga ggacaggctg catttctacg      780

tggaggaatg tgactacttg cagggcttcc agatcctgtg tgacctgcac gatggcttct      840

ctggggtagg cgcgaaggcg gcagagctgc tacaagatga atattca                    887


<210> 4249
<211> 3505
<212> DNA
<213> Homo sapiens

<400> 4249
atcgcagcga gagcgttttt gcctgtggag agccggccga cgggagccgc ggcggagcct       60

gttgagctcg cgcgggctgc cgggagtggt ctctgaggcg gcggcggcgg cggggatcgt      120

ctccggcact gacgcaccat gtcggtcagt gtccatgaga cccgcaagtc gcggagcagc      180

acggggtcca tgaacgtcac cctcttccac aaggcctccc acccggactg tgtgctggcc      240

gcctctagcc gctattttga ggccatgttc agccatggcc ttcgggagag ccgggatgac      300

actgtcaact tccaggacaa cctgcacccg gaggtgctgg agctgctgct ggactttgcc      360

tactcctcac gcatcgccat caacgaggag aacgctgagt cactgctgga ggcaggcgac      420

atgctgcagt tccacgatgt gcgggatgct gccgccgagt tcctggagaa gaaccttttc      480

ccctccaact gcctgggcat gatgctgctc tcggacgccc accagtgccg ccggctgtat      540

gagttctcct ggcgcatgtg cctggtgcac tttgagacgg tgaggcagag cgaggacttc      600

aacagcctgt ccaaggacac actgctggac ctcatctcga gtgatgagct ggagaccgag      660

gacgagcggg tggtcttcga ggccatcctc cagtgggtga agcacgacct ggagccacgg      720

aaggtccact tgcccgagct cctccgcagc gtgcgtctgg ccttgctgcc gtccgactgc      780

ctgcaggagg ccgtctccag cgaggccctc ctcatggcag acgagcgcac caagcttatc      840

atggatgagg ccctgcgctg caagaccagg atcctgcaga atgatggcgt ggtcaccagc      900

ccctgtgccc ggccacgcaa ggcgggccac acgctactca tcctgggggg ccagaccttc      960

atgtgtgaca agatctacca ggtggaccac aaggccaagg agatcatccc caaggccgac     1020

ctgcccagcc cccggaagga gttcagcgcc tcagcgatcg gctgcaaggt ctatgtgacg     1080

gggggcaggg gctccgagaa cggggtctcc aaggatgtct gggtgtacga caccgtacat     1140

gaggaatggt ccaaggcggc gcccatgctg attgcccgct ttggccatgg ctcagctgag     1200

ctggagaact gcctctatgt ggtgggggga cacacatccc tggcaggggt cttcccggcc     1260

tcgccttctg tctccctgaa acaagtggag aaatacgacc ctggggccaa caagtggatg     1320

atggtggccc ccttgcggga tggcgtcagc aatgccgcag tggtgagtgc caagctgaag     1380

ctctttgttt tcggaggaac cagcatccac cgggacatgg tgtccaaggt ccagtgctat     1440

gacccctcgg agaacaggtg gacgatcaag gccgagtgcc cccagccttg gcggtacaca     1500

gccgctgccg tcctgggcag ccagatcttc atcatgggag gtgacacgga attcacagcc     1560

gcctcggcct accgctttga ctgtgagacc aaccagtgga cgcggattgg ggacatgact     1620

gccaagcgca tgtcctgcca tgccctggct tccggcaaca agctctatgt ggtcgggggc     1680

tactttggga cccagaggtg taagactctg gactgctatg accccacttc agatacatgg     1740

aactgcatca ccacagtgcc ctactcactt atccccacgg cctttgtcag cacctggaag     1800

cacctgcccg cgtgaggagc acctgctgag cccagccaga ccgcggcctt cagtgtcaca     1860

gcgtggcctt gcttgtctgc cacagcggga gctaagccgg ccctgggcca gcactccgag     1920

aggtggaagg ggccctgcca gctctgggga gcagcagcct tgggctgttc tgagctttag     1980

gcaagagaag agaagcatct cttgcatccg tgcccctggg ggcctcttca gctttgcagt     2040

ggtttgtggg aagacatacc tcccagaggg gcatggactg ccaccaggac tgaccctggc     2100

gtcggggaga aggacacttg cagagccttg agatcacctg tttggcaggt cctggactgg     2160

ggccgggcag gcaggggcag ggaggcgccc cgggtgggct ttggggctgc ggcactgcca     2220

cacatccttt ccctcctggc ctgccctgct ggggctctac tgccatctat agatggtgtc     2280

ctgggcctgg gaaactaggt tcccaggggt tgagaccaga aaggtgacca agacagattt     2340

tttaaggtgc agaaactgca ggggggcctc agtgacatcc atgaggcctt attagcaaag     2400

gacacccaga cctccaaggt ttgtgggccc cttccacaaa gctgtaagtc ccagcccacc     2460

tactcagggc cttgctcagt gctgtggccc ggtggggaca cagttgctcg tggccactca     2520

gtggagctgg gcctgcagca gactcaaggc tccgagtgcc ctgggggtca cccctcccct     2580

cccctcctca gagcccaccc tgagaggcag cagtgacccc catggcacac acctgccaac     2640

agcactgggg gcttctcccc aggagaccac gctgccctcc aagaccagga gcagctgtga     2700

gctggagaca gcagagggac cccagggtgt cccctgcaga tcccaccagg gccgcatcca     2760

tctcagtgtg gaggacagtg acgggaccct caccatcctc ttgcgttttg gcccccattt     2820

gctccctgag ctccaagata agaatggccc cgagagaact gctgaacatt tgttcattgc     2880

tgtcacctcc tgagtcactg gggtccctca ccagcacctc cctgacacct gggctatgga     2940

gaggttggcg cctgtcagtg accatcctaa tgcctctcgc tcactcccaa gccaccattt     3000

gagagggagg ggtgttggtg ccctgacagg gactgggcag ggtgtccaaa cttggggctt     3060

cccaggcacc tgcagtgtga acactgcttg gctggctcaa gattagggcc gcggaggggg     3120

ctgtgcacat accagttact taagcagcca cgagtgtccc ccatgccttg gtgcgggtcc     3180

tggaggcctc ttgggggtgg gacctttggg cagggtttgc ccactgacac gcccgccatg     3240

gggcactggc tgcatggggc tccttggacc ctgtagaccc agcagacccc gcctgtgtca     3300

ggccagctgc ccgaaggcac ttggctgtgg tcccagggga cggctctgct ggcacactca     3360

ggagcctggc cgcggggact gcagggaggg tgcctggacc cgtggggttg cttcattgag     3420

ataaagcaca cttatcacat agcacaaagg acgtgccatg gtgctttccc caaaagttgt     3480

gttgctttta tcagttttct aactt                                           3505


<210> 4250
<211> 2916
<212> DNA
<213> Homo sapiens

<400> 4250
atgaatttcc tccgcggggt aatggggggt cagagtgccg gaccccagca cacagaagcc       60

gagacggtga gaggagcagc gggtctggga cttgggaagg ggtccgggca gggacgggga      120

cggagcactc ggagacccga agagtgtgga cttaaattta gacatagttt tcgtttagtc      180

aagcacattt tataccatgt tactataaat gtttcagatt ctgaaataat aggttatgct      240

ttggacacac tatataatat aatatctaat gaagaagaag aagaagtagg cggatcacaa      300

gaagaaaatt ccacaagaca gagtgaagat ttgggaagcc aatttacaga aattttcatt      360

aagcagcagg aaaatgtcac tcttctgtta tctttattgg aggagtttga tttccatgtc      420

cgctggcctg gtgtgaagct tcttacttct cttttaaaac aactagggcc tcaggtgcaa      480

caaattattt tagtcagtcc tatgggtgtt tcaagattga tggacttact agcggattcc      540

agggaagtta tacgtaatga tggcgtctta ctactgcagg cactaacaag aagcaatggt      600

gcaatccaga aaattgttgc ttttgaaaat gctttcgaga gactactgga cattatttca      660

gaggagggga acagtgatgg aggtatagta gttgaagatt gtttgatttt gctccaaaac      720

ttattaaaaa acaacaactc caatcaaaat ttttttaaag aaggctcata tattcaacgt      780

atgaaacctt ggtttgaagt tggagatgaa aattctggct ggtctgcaca gaaagtgacc      840

aatctacatc taatgctaca gcttgttcgt gtattggtat ctcccaccaa ccctcctggt      900

gctaccagta gctgccagaa ggctatgttc cagtgtgggt tattgcagca gctttgtact      960

atcctaatgg ctactggggt tcctgctgat atcctgactg agaccataaa tactgtatca     1020

gaagttattc gaggctgcca agtaaaccaa gactactttg catctgtaaa tgcaccttca     1080

aacccaccaa gaccggcaat tgtagtactt ctcatgtcca tggttaatga aaggcagcca     1140

tttgttttgc gctgtgctgt tctctattgt ttccagtgtt tcttgtataa aaaccaaaaa     1200

ggacaaggag aaatcgtgtc aacactttta ccttctacca ttgatgcaac aggtaattca     1260

gtttcagctg gccagttatt atgtggaggt ttgttttcta ctgattcact ttcaaactgg     1320

tgtgctgctg tggcccttgc ccatgcgttg caagaaaatg ccacccagaa agaacagttg     1380

ctcagggttc aacttgctac aagtattggc aaccctccag tttctttact tcaacagtgc     1440

accaatattc tttcacaggg tgataagatc gacagacggg gaagcaaaat acaaacaaga     1500

gttggattat taatgttgct ttgtacctgg ctaagcaatt gtcccattgc agtaacgcat     1560

tttcttcaca attcagccaa tgttccattt cttacaggac aaattgcaga aaatcttgga     1620

gaagaagagc agttggtcca aggcttatgt gcccttttgt tgggcatttc gatttatttc     1680

aatgataact cacttgagag ctacatgaaa gagaagctaa aacaactgat tgagaagagg     1740

attggcaaag agaatttcat agagaaacta ggatttatta gcaaacatga gttgtattcc     1800

agagcatctc agaaacccca gccaaacttt cccagtccag aatacatgat atttgatcat     1860

gagtttacga agctggtaaa agaacttgaa ggtgttataa ctaaggctat ttataagtcc     1920

agtgaagaag ataaaaaaga agaagaggtg aaaaaaacat tagaacagca tgacaatatt     1980

gtgactcact acaaaaatat gattcgagag caggatctcc aacttgagga attaaggcag     2040

caggtttcta cattaaaatg tcaaaatgaa cagctccaga cggcagtcac acagcaagta     2100

tcacagatcc agcagcacaa agaccagtat aatcttctta aaatacagct aggaaaagac     2160

aatcagcatc aaggttctta cagtgagggg gctcagatga atggcattca gccagaagaa     2220

attggtagat tgcgagaaga gatagaagaa ttaaaacgta atcaggaact tttacaaagc     2280

cagctgactg aaaaggactc tatgattgaa aatatgaaat cttcccaaac atctggcaca     2340

aatgaacagt cttcagcaat agtttcagct agagattctg aacaagttgc agaattaaaa     2400

caggaactgg caactttaaa gtctcagtta aactcacaat ctgtggagat caccaaacta     2460

cagacagaaa agcaggaact gttacagaaa acagaagcgt ttgcaaaatc agttgaggta     2520

caaggagaga ccgagactat aatagccacc aaaactactg atgtagaagg aagactgtca     2580

gcattattac aagagaccaa agagttaaag aatgaaatta aagctctgtc tgaggaaaga     2640

actgccatta aagagcagct ggattcatct aatagtacca ttgccatttt acaaactgag     2700

aaagacaaac tagagttgga aattacagat tctaaaaaag aacaagatga tctcttggtg     2760

ctcttggccg atcaagatca gaaaatactg tcattgaaga ataaactcaa ggatcttggt     2820

catccagttg aagaagagga tgaacttgaa tctggagacc aagaggatga ggatgatgaa     2880

agtgaagatc ctggcaagga tctagatcat atctag                               2916


<210> 4251
<211> 642
<212> DNA
<213> Homo sapiens

<400> 4251
gcgttttatg agccatatgg aagtctgaag agctgctcag ctctgacagc tgtttaaatt       60

atctgtgaca ctgcatccca ccattagcag ggatgatgga ttgttgacag tctccatcag      120

aaaaggctgg agtcccagtc cgtggaggag cacttacagg gtctttccta agtgctgagg      180

ctctgtgtat gaatgacaag gataccttca gccagctcat tctggatgaa tgaatgatta      240

cactaagtgt cctccacatt cctctgtggg ctcacttcat ggactcactt tgcgtgcttg      300

ttaaatgtgc tgtgttgctc ccaagaccat gtaaagccta ctgaccacta acctccctca      360

cagcagaaac tagacgtcag gttaaaatgg gcaactccga cagtcagtac acccttcaag      420

gatctaaaaa tcatagcaat actattactg gtgctaagca aattccttgc tccctgaaaa      480

tacgtggcat tcatgcaaaa gaggaaaagt cattgcatgg atggggtcac ggaagcaacg      540

gagcaggtta caagtccagg tccctggccc gaagctgcct ttctcacttt aagagtaacc      600

agccttacgc atcgagactc ggtggcccca catgcaaggt ct                         642


<210> 4252
<211> 2391
<212> DNA
<213> Homo sapiens

<400> 4252
gggggcgggc tcccggtccc gctatcggcg gccggcgggc aggcgactcc tgtcccgggt       60

ggaggcggcg gagccggagc cgggggaggg ggcagcggct gtctcacgga ccacggcggc      120

gcccgcagct cctcaccgaa acaaggagac cagtgctggt ccagtggctg tgatgggaaa      180

agattattac aagattcttg ggatcccatc gggggccaac gaggatgaga tcaagaaagc      240

ctaccggaag atggccttga agtaccaccc agacaagaat aaagaaccca acgctgagga      300

gaagtttaag gagattgcag aggcctatga tgtgctaagt gaccccaaga aacggggcct      360

gtatgaccag tatggggagg aaggcctgaa gaccggcggt ggcacatcag gtggctccag      420

tggctccttt cactacacct ttcatgggga cccccatgcc acctttgcct ccttctttgg      480

tggctccaac cccttcgata tcttctttgc cagcagccgc tccactcggc ccttcagtgg      540

ctttgaccca gatgacatgg atgtggatga agatgaggac ccatttggcg ctttcggccg      600

ttttggcttc aatgggctga gtaggggtcc aaggcgagcc ccagaaccac tgtaccctcg      660

gcgcaaggtg caggaccccc cagtggtgca cgagctgcgg gtgtccctgg aggagatcta      720

ccatggctcc accaagcgca tgaagatcac aaggcgtcgc ctcaaccctg atgggcgaac      780

tgtgcgcacc gaggacaaga tcctgcacat agtcatcaag cgtggctgga aggaaggcac      840

caagatcacc ttccccaaag aaggcgacgc cacacctgac aacatccctg ctgacatcgt      900

ctttgtgctc aaagacaagc cccatgcaca cttccgccga gatggcacca acgtgctcta      960

cagtgccctg atcagcctca aggaggcgct gtgtggctgc actgtgaaca ttcccactat     1020

cgacggccga gtgatccctt tgccctgcaa tgatgtcatc aagccaggca ccgtgaagag     1080

actccgtggg gagggccttc ccttccccaa agtgccaact cagcgaggag acctcattgt     1140

tgagttcaaa gttcgcttcc cagacagatt aacaccacag acaagacaga tccttaagca     1200

gcacctaccc tgttcctagg ctctgcccca gccagtccag agcctaccac agcaataccc     1260

ccaacactca ctccactcaa tgtgcaccca gcttgatgtc cactggacac tggcaacttt     1320

ttctaaaatg caaaaaaaag ccactggttt tcaggaaaat gttcctgtcc ctgacccctt     1380

ttagagctgg gctgcctggg gggagtggga gggaggtggg gagagctagc ccaggccagg     1440

ggtcaatgtt catgtcacta gctttcaatc cagtttccac tgcagtggct ggagagtgac     1500

ctgagtgcta cttgaagata tgtagagatt ccttatccat gcctgtacat agcatgtcct     1560

cctcccctca gctttgctaa taccagtccc ctcccttccc tttggcttcc tgctgttggg     1620

ggtggaaaag actagaaagg acattgcttt ctcagcccca cccccaggtc cacagtgtcc     1680

aaggtaatgg cacacatatt catgcacaag aagcactcac ctagagctgt ctgtgcctct     1740

ctgggagaaa ggagagagga taagaaggga aagttcacaa cctgtgaaca gggacttgag     1800

cacgagacac ttttcatctg gagcaggggg gtgagctcct cagcagcctc cgtaacagct     1860

gccctgccta cacctgcaga gctggaggtt ctgtcctccc tgctgctctc aggagtgttc     1920

aagggtggag ggcagggaat ggggcctgag gtattaaggc taagaggtgg gggacagggc     1980

ccatctacca gccttcatca ggaagggaaa gggctttggg gtcaggtggc agctattccc     2040

caccaagaga ttcagggtca caggtttttc cccacacctc tgaactcagg gcctagccac     2100

ccccaaactt ccaaatccca cttttgtgat atgtgaagct actcatttct tacccttgga     2160

ggctgtgtgg ggaatttcca gcccttttat gcctgtgtga tcccacccca cccccatagt     2220

tgtataaagg tcatagtgaa gaagctgggg gaagactgct tcagccagat cctggggtgg     2280

ggtctttagg ttttctcact ttgacaaccc ccgaatgttt ttatagtagt ttttttgtat     2340

ttttttgtaa tgacagtatt atgtaaaaaa taaagtattt taaaaatatg g              2391


<210> 4253
<211> 1434
<212> DNA
<213> Homo sapiens

<400> 4253
gagcatttcc ggcagccatc cccgcggtgc tgacatcccg gttgttcttc tgtgccgggg       60

gtcttcctgc tgtcatgaag gacgtaccgg gcttcctaca gcagagccag aactccgggc      120

ccgggcagcc cgctgtgtgg caccgtctgg aggagctcta cacgaagaag ttgtggcatc      180

agctgacact tcaggtgctt gattttgtgc aggatccgtg ctttgcccaa ggagatggtc      240

tcattaaggg tgaacccttt gtccctcgtg gaaatcattc ttcatgtagt tagacagatg      300

actgatccta atgtggctct tacttttctg gaaaagactc gtgagaaggt gaaaagtagt      360

gatgaggcag tgatcctgtg taaaacagca attggagctc taaaattaaa catcggggac      420

ctacaggtta caaaggaaac aattgaagat gttgaagaaa tgctcaacaa ccttcctggt      480

gtgacatcgg ttcacagtcg tttctatgat ctctccagta aatactatca aacaatcgga      540

aaccacgcgt cctactacaa agatgctctg cggtttttgg gctgtgttga catcaaggat      600

ctaccagtgt ctgagcagca ggagagagcc ttcacgctgg ggctagcagg acttctcggc      660

gagggagttt ttaactttgg agaactcctc atgcaccctg tgctggagtc cctgaggaat      720

actgaccggc agtggctgat tgacaccctc tatgccttca acagtggcaa cgtagagcgg      780

ttccagactc tgaagactgc ctggggccag cagcctgatt tagcagctaa tgaagcccag      840

cttctgagga aaattcagtt gttgtgcctc atggagatga ctttcacacg acctgccaat      900

cacagacaac tcacttttga agaaattgcc aaaagtgcta aaatcacagt gaatgaggtg      960

gagcttctgg tgatgaaggc cctttcggtg gggctggtga aaggcagtat agacgaggtg     1020

gacaaacgag tccacatgac ctgggtgcag ccccgagtgt tggatttgca acagatcaag     1080

ggaatgaagg accgcctgga gttctggtgc acggatgtga agagcatgga gatgctggtg     1140

gagcaccagg cccatgacat cctcacctag ggccccctgg ttccccgtcg tgtctccttt     1200

gactcacctg agagaggcgt ttgcagccaa tgaagctggc tgctcagacg gtcgacattg     1260

aatttgggtg ggggtctcag ggtcttaggt gatacgggag agaaagaacg tgccaggcag     1320

gaggccccct gaagtctgtg tactccgagg tggatctcca tccccatcca cctgtacgga     1380

catcttttcc gttgcggttt gagaatgttc ctataataaa cccctctgct ttgt           1434


<210> 4254
<211> 2242
<212> DNA
<213> Homo sapiens

<400> 4254
acagagttgt cctcggaggt ccaggacagc ggccagcccg gcggcgggag tcagggccac       60

gccacctgca gggaagaacc cgagtcgaag cgggaagatg gctgcagaca agcctgcaga      120

tcagggagca gagaaacatg aaggcacagg tcagtcctct gggatcactg atcaagagaa      180

ggagttatcc accaatgctt tccaagcttt cacatctgga aattatgatg cctgtctaca      240

acaccttgcc tgtctacaag atataaacaa agatgattat aaaataattt tgaatacagc      300

agtagctgag ttttttaaaa gtaaccaaac aacaacagat aatttgagac aaacacttaa      360

ccagctgaag aatcaggtcc actcagctgt tgaagaaatg gatggattag atgatgttga      420

aaacagcatg ttgtactata atcaagcagt cattctttat catctgcggc agtatacaga      480

agccatatca gttggtgaaa aactttatca gttcatagag ccttttgact ggtaataaca      540

acaacaaaga tggatctaat cataaagctg aaagtggagc tctaatagaa gctgcaaaat      600

caaagataca tcagtacaaa gtacgagctt atatccaaat gaagtctctg aaagcatgta      660

aaagggaaat caagtcagtc atgaatacag ctggaaattc cgcaccctct ctctttctta      720

aaagcaattt tgagtactta agaggtaatt atcgaaaagc cgtgaagcta ttaaatagtt      780

caaacattgc tgagcatcca ggattcatga aaacaggtga atgcttgaga tgcatgttct      840

ggaataacct tggttgcatc cattttgcca tgagcaagca caatttggga atattctact      900

ttaaaaaggc tctgcaagag aatgacaatg tctgtgcaca gctcagtgca ggtagcactg      960

atccaggtaa aaaattttca ggaagaccca tgtgtacgtt actaaccaat aagagatatg     1020

agttgctgta taactgtgga attcagcttc ttcacattgg aaggcctctt gctgccttcg     1080

aatgtctgat tgaagctgtt caggtttatc atgcaaatcc tcgcctctgg ctacggctgg     1140

ctgaatgctg cattgctgcc aataagggga cttctgaaca agaaactaaa ggccttccca     1200

gcaaaaaagg aattgtacag tctattgttg gtcaaggcta tcatcgtaaa atagttttgg     1260

catcacagtc tatacagaat actgtttata atgatgggca gtcttcggcc attcctgtag     1320

ccagtatgga gtttgcagcc atatgtctca gaaatgcctt gttgctgcta cctgaagaac     1380

agcaagatcc aaagcaggaa aatggggcta aaaatagtaa tcaattaggt gggaacacag     1440

agagcagcga aagcagtgaa acttgcagca gtaaaagcca tgatggagat aaattcattc     1500

cagctccacc ttcttctcca ttgagaaaac aggaattaga aaacttaaag tgctccatac     1560

ttgcttgcag tgcctacgtg gctctggctt tgggtgataa cctcatggct ttgaatcatg     1620

cagataaact tcttcagcag cccaagctgt caggatctct taagtttttg ggacatttat     1680

atgctgcaga agccctcatc tctctcgaca gaatatctga tgccattact cacttgaacc     1740

cggagaatgt cactgatgtc tccttaggga tctcttcaaa tgagcaggac caaggttaat     1800

gaggacatct ttgatcagaa ctggtcactg tttccatttc cctcctgtca taattcagga     1860

tgtgtggaaa tttaggcatg gtggtaatga gaagaaagtt ttaggttggc tttccacatt     1920

tttgtctgta cttactttgt agcagttgtt tgctaagtag acctgagagt taatgatcac     1980

atcatctaaa ttctcacttt tgaaaggctg gtactgttag aatggttaat tttggttctg     2040

atactattta tttgttttcc tttggagtga ttctaaaatc cataggggag taaaaatatt     2100

gcattcaaga gtcagtttta gtccaggcgt ggtggctcac gcctgtaatc ccagcacttt     2160

gggaggctgt agcaggaggg tcacttgagc ccaagagttc aagaccagcc tgggcaacct     2220

ggtgagaccc tgtctctatt tt                                              2242


<210> 4255
<211> 1933
<212> DNA
<213> Homo sapiens

<400> 4255
agaaagatgg cggcgatggc ggtcgggggt gctggtggga gccgcgtgtc cagcgggagg       60

gacctgaatt gcgtccccga aatagctgac acactagggg ctgtggccaa gcaggggtga      120

gggccggacc tccacgagcg gaatgcgggg tccgaactcg gggacggaga agggcagact      180

agtcatcccg gagaagcagg gactggaata cgctaattgt gggaaagctt tctccatgga      240

ttcgtccaga ctcaaaagtg gagaagattc gcaggaactc cgaggcggcc atgttacagg      300

agctgaattt tggtgcatat ttgggtcttc cagctttcct gctgcccctt aatcaggaag      360

ataacaccaa cctggccaga gttttgacca accacatcca cactggccat cactcttcca      420

tgttctggat gcgggtaccc ttggtggcac cagaggacct gagagatgat ataattgaga      480

atgcaccaac tacacacaca gaggagtaca gtggggagga gaaaacgtgg atgtggtggc      540

acaacttccg gactttgtgt gactatagta agaggattgc agtggctctt gaaattgggg      600

ctgacctccc atctaatcat gtcattgatc gctggcttgg ggagcccatc aaagcagcca      660

ttctccccac tagcattttc ctgaccaata agaagggatt tcctgttctt tctaagatgc      720

accagaggct catcttccgg ctcctcaagt tggaggtgca gttcatcatc acaggcacca      780

accaccactc agagaaggag ttctgctcct acctccaata cctggaatac ttaagccaga      840

accgtcctcc acctaatgcc tatgaactct ttgccaaggg ctatgaagac tatctgcagt      900

ccccgcttca gccactgatg gacaatctgg aatctcagac atatgaagtg tttgaaaagg      960

accccatcaa atactctcag taccagcagg ccatctataa atgtctgcta gaccgagtac     1020

cagaagagga gaaggatacc aatgtccagg tactgatggt gctgggagca ggacggggac     1080

ccctggtgaa cgcttccctg cgggcagcca agcaggccga ccggcggata aagctgtatg     1140

ctgtggagaa aaacccaaat gccgtggtga cgctagagaa ctggcagttt gaagaatggg     1200

gaagccaagt gaccgtagtc tcatcagaca tgagggaatg ggtggctcca gagaaagcag     1260

acatcattgt cagtgagctt ctgggctcat ttgctgacaa tgaattgtcg cctgagtgcc     1320

tggatggagc ccagcacttc ctaaaagatg atggtgtgag catccccggg gagtacactt     1380

cctttctggc tcccatctct tcctccaagc tgtacaatga ggtccgagcc tgtagggaga     1440

aggaccgtga ccctgaggcc cagtttgaga tgccttatgt ggtacggctg cacaacttcc     1500

accagctctc tgcaccccag ccctgtttca ccttcagcca tcccaacaga gatcctatga     1560

ttgacaacaa ccgctattgc accttggaat ttcctgtgga ggtgaacaca gtactacatg     1620

gctttgccgg ctactttgag actgtgcttt atcaggacat cactctgagt atccgtccag     1680

agactcactc tcctgggatg ttctcatggt ttcccatcct cttccctatt aagcagccca     1740

taacggtacg tgaaggccaa accatctgtg tgcgtttctg gcgatgcagc aattccaaga     1800

aggtgtggta tgagtgggct gtgacagcac cagtctgttc tgctattcat aaccccacag     1860

gccgctcata taccattggc ctctagccct gcgtgccaag tgtccagagc cttggaagca     1920

gcttcaggtt ctg                                                        1933


<210> 4256
<211> 1862
<212> DNA
<213> Homo sapiens

<400> 4256
agtctagtgg gataccaggc cctgagagac ccctacgatc ccaggacact gatgtggggt       60

aactaacacc cactggaagt ctacgctgag ttcacaggct atgtatgacc tgacatgcat      120

tttgacctgc cctgtgtttt gatatttgaa tgagttgctg atgtttacaa gccgaagctg      180

gccgggcgtg gtggctcgcg cctgtaatcc cagcactttg ggaggtcgag gcaggaggat      240

cgcttcaggt caggagttcc agaccagtct ggccaacatg gcgaaacctc gtctctacta      300

aaaaaaaaaa aaaaaaaaaa aatacaaaaa ttagccgggc gtggtggcac gcccctgtaa      360

tcccaggact cgggaggctg agacaattat aaattcatta acccccagaa ctcttggcta      420

gacttcataa aggcaaaaac tgtgtttgcc ctgttaactg ctttatccca ccactagaat      480

ataagcttcc tgaagacaga agacttctgt tattttgttc acagttacca agcatgccta      540

ctttgttaaa tttatgaaag aactttaaag agtcagaggt tccggttgag atcaagttgg      600

gagacacacc cttgttcatt ctccttgaga agcagctatt atcaacagaa cattgacaga      660

acctgtgttt ggggaaagga ctgatggctt tgagtctagg ttggaaagca cacaggaacc      720

actgtggtct cctcttgcag gctctgcgaa gcagtggtct tctcttgttt ccctgtggcc      780

agtgtccctg gagaggagct ggaagctttt tggaccctga gataaaggct ttcctggagg      840

agaacactga agtcaccagc agtggtagcc tcacccctga aatccagttg cggcttttga      900

cccccagatg caaattctgg tgggagagag ctgacctgtg gccccacagt gatccttact      960

gggcaatcta ctggccagga ggccaagccc tgtctaggta tcttttggat aatcctgatg     1020

ttgtcagagg aaaatctgta ttagatcttg ggagtggatg tggagctaca gctattgctg     1080

ctaagatgag tggggcatca aggatcttgg ccaatgacat agaccctatt gcaggaatgg     1140

ctattacact aaattgtgaa ttgaacagac tgaatccttt tcctatttta atccaaaaca     1200

ttttgaattt ggaacaagat aagtgggacc ttgttgttct tggcgatatg ttttatgatg     1260

aagaccttgc agatagtctt catcagtggc tgaagaagtg cttctggacc tatagaactc     1320

gagtactgat tggtgaccct gggcggcccc agttcagtgg acacagcatt cagcatcacc     1380

tgcacaaagt ggtagaatat tcacttttgg agtctactag gcaggaaaac agtggactga     1440

caacaagcac agtgtggggt tttcagcctt gagttgtcaa agtgcttcca agtatgaata     1500

tagtaatgtt tggatctgac tctaaaagtt ttctctatag gagatactct ccagtttaat     1560

gaatgtaatt cttgttaaat ggaaaatctt gtttttaaaa tatgaaggtt tagagttttg     1620

tttacttttg tcatgtaact ggttctgtat ttctatgcat gccaattata cacatctcta     1680

tctgcatttt tttttctatt ttaaccgctg aaggaatatg attatacaat gccatactca     1740

atggtggcag catttaattt aagtaatgga gaagaattaa acattgtagc tggatctgtt     1800

tctgtagtcg aggacaactg tgatgtaact ttgaattaaa caaacaaaac aaaacagaag     1860

aa                                                                    1862


<210> 4257
<211> 1401
<212> DNA
<213> Homo sapiens

<400> 4257
cttcactccc aacaatggcg gctccgagcc cgagcggcac ccccgtcagc agcatgcagg       60

gtaaacgcaa agcactgaag ttgaattttg caaatccacc tttcaaatct acagcaaggt      120

ttactctgaa tcccaatcct acaggagttc aaaacccaca catagagaga ctgagaacac      180

acagcattga gtcatcagga aaactgaaga tctcccctga acaacactgg gatttcactg      240

cagaggactt gaaagacctt ggagaaattg gacgaggagc ttatggttct gtcaacaaaa      300

tggtccacaa accaagtggg caaataatgg cagttaaaag aattcggtca acagtggatg      360

aaaaagaaca aaaacaactt cttatggatt tggatgtagt aatgcggagt agtgattgcc      420

catacattgt tcagttttat ggtgcactct tcagagaggg tgactgttgg atctgtatgg      480

aactcatgtc tacctcgttt gataagtttt acaaatatgt atatagtgta ttagatgatg      540

ttattccaga agaaatttta ggcaaaatca ctttagcaac tgtgaaagca ctaaaccact      600

taaaagaaaa cttgaaaatt attcacagag atatcaaacc ttccaatatt cttctggaca      660

gaagtggaaa tattaagctc tgtgacttcg gcatcagtgg acagcttgtg gactctattg      720

ccaagacaag agatgctggc tgtaggccat acatggcacc tgaaagaata gacccaagcg      780

catcacgaca aggatatgat gtccgctctg atgtctggag tttggggatc acattgtatg      840

agttggccac aggccgattt ccttatccaa agtggaatag tgtatttgat caactaacac      900

aagtcgtgaa aggagatcct ccgcagctga gtaattctga ggaaagggaa ttctccccga      960

gtttcatcaa ctttgtcaac ttgtgcctta cgaaggatga atccaaaagg ccaaagtata     1020

aagagcttct gaaacatccc tttattttga tgtatgaaga acgtgccgtt gaggtcgcat     1080

gctatgtttg taaaatcctg gatcaaatgc cagctactcc cagctctccc atgtatgtcg     1140

attgatatcg ctgctacatc agactctaga aaaaagggct gagaggaagc aagacgtaaa     1200

gaattttcat cccgtatcac agtgttttta ttgctcgccc agacaccatg tgcaataaga     1260

ttggtgttcg tttccatcat gtctgtatac tcctgtcacc tagaacgtgc atccttgtaa     1320

tacctgattg atcacacagt gttagtgctg gtcagagaga cctcatcctg ctcttttgtg     1380

atgaacatat tcatgaaatg t                                               1401


<210> 4258
<211> 8446
<212> DNA
<213> Homo sapiens

<400> 4258
atttccggct tctgggactc gggtgcacca cggcttccgg tgtcatggct gcttgaagtc       60

ccgggagtcg gtgaggcggc tgcaggtccc tccctgcgga gccgctggtc cggctggcgg      120

agatgtgacc gcgggcccgg ccggcctgcc tcaggcgtcg cgtcagctcc cgtgtccgtg      180

cccttaaccc acaccgatgg cgggatccgg ctgcgcctgg ggcgcggagc cgccgcgttt      240

tctggaggcc ttcgggcggc tgtggcaggt acagagccgt ctgggtagcg gctcctccgc      300

ctcggtgtat cgggttcgct gctgcggcaa ccctggctcg ccccccggcg ccctcaagca      360

gttcttgccg ccaggaacca ccggggctgc ggcctctgcc gccgagtatg gtttccgcaa      420

agagagggcg gcgctggaac agttgcaggg tcacagaaac atcgtgactt tgtatggagt      480

gtttacaatc cacttttctc caaatgtgcc atcacgctgt ctgttgcttg aactcctgga      540

tgtcagtgtt tcggaattgc tcttatattc cagtcaccag ggttgttcca tgtggatgat      600

acagcattgt gcccgagatg ttttggaggc ccttgctttt cttcatcatg agggctatgt      660

ccatgcggac ctcaaaccac gtaacatatt gtggagtgca gagaatgaat gttttaaact      720

cattgacttt ggacttagct tcaaagaagg caatcaggat gtaaagtata ttcagacaga      780

cgggtatcgg gctccagaag cagaattgca aaattgcttg gcccaggctg gcctgcagag      840

tgatacagaa tgtacctcag ctgttgatct gtggagccta ggaatcattt tactggaaat      900

gttctcagga atgaaactga aacatacagt cagatctcag gaatggaagg caaacagttc      960

tgctattatt gatcacatat ttgccagtaa agcagtggtg aatgccgcaa ttccagccta     1020

tcacctaaga gaccttatca aaagcatgct tcatgatgat ccaagcagaa gaattcctgc     1080

tgaaatggca ttgtgcagcc cattctttag cattcctttt gcccctcata ttgaagatct     1140

ggtcatgctt cccactccag tgctaagact gctgaatgtg ctggatgatg attatcttga     1200

gaatgaagag gaatatgaag gtctttgttg agtatgcaaa tgctggtgat tccaaagctg     1260

cgcagaaatt actgactgga aggatgtttg atgggaagtt tgttgtggct acattctacc     1320

cgctgagtgc ctacaagagg ggatatctgt atcaaacctt gctttaatca gtaacctaag     1380

gactgtttcc tttttctcct cttccatttc ttgggttatt ccacatatga atgcaggact     1440

acccccttac cattttaaga aggtacttta tacatttatt taatcctact aatgtgcagc     1500

cattgcccaa gcagtgactg cgttgcatac atttggcact gagtaggaca agacctctca     1560

gctatacatt gaggggtttt agagcatcca tgtgggcaac ccttttttgt gcgggagagc     1620

aggtgttgct cttcagtatg tagcctaaaa aaatcttaat tatttcatgg atcatgaagc     1680

aaggatgaat aatatcatgt cttggtaaat actaacaaat ttgttaggtt tggtgacatc     1740

atttacagat tatttcttta tgttgtccag tggttcttcc ttattgttga tatccataag     1800

ctggcactgg atgctctcag taatgttaag taattgtcaa gcagcagtta cctactgtgt     1860

tcttaacact gagttgtgaa ttttttctta aagcagtact gtagtactga atattccttt     1920

aaaggaactg cagtgagcct atctaagttt ttttaaatta aggcttttaa aatagaaagc     1980

tgatgcttga tcttgcacaa tttttatgtc tagtatgtat gcttgagtga atgtgcgagt     2040

atgaatgatt agagaaaatt tgagtcagtg tactttatag tgtgaatcct gtgagctaat     2100

acagtctata cttatttctt ccctacctgt ttcacatccg taagatttaa gatatacatt     2160

ttttgagagg tagtctgtct gatacaatgt aaatgacaaa acataattcc tgagaggccc     2220

agaacaaact ggagtctagc ctggagttaa attgagactt ctaaaatgat tggaacaaag     2280

actaagttgt gccagatgta aatcaacccc tcttttagtt tactttagac tttgtattag     2340

ctcatctttt ttgtagtaaa tctatagttt taaggtttct caagatgtgg ctctacctac     2400

tatgatgaaa attgaagtgg gtcaaaagaa ttagatgtac agtgaaggga aaagaaaaaa     2460

aatgggcgaa gagagggtgg aaaataaaag gattcttttt tcttcctttc tgtttctcgt     2520

atccctgctc cctttttcct ccccttccct cattctttgc ctctatcctt agctgaagac     2580

aaactagagg agcagcatcc caggtagttt ggcttttgac tgcaaggtag ttaagaaagg     2640

tgtagatata atgaggtaga agtagaaagg aagaaaaact caaagaattc ttaaaaggat     2700

tcatagcaac ataatgtgtc cctgagtaga ggatgctgct atgcgtgagt tcatggacac     2760

aagttgatta catggttttt agaattataa ttatggattc ttcttatttc atggtaggtt     2820

gtctttaaag atataaaaat taggatgcct ttatgaagca ctgattatac caaaaaaaaa     2880

agacaagtta tatacaggtt attaattttt ttatttattt attttttcct aaggaaaaag     2940

tcttctatct ttccctgctg gaagcctcct catatttcct tatgtttgcc atgcaggttg     3000

ctgagagtcc agttagaatt tgcattttac agaatgaaat actttacccc attcaaacaa     3060

ttattgtttg acattttagt tatttataat tgtcaaattc aggactctcc tttaatgttt     3120

attatgaaac caaatttggc ataaggaggc tgatttatga attaccaaag ggtcttgtgg     3180

catgttcccc aatacatgcc cttagaagga agaactatta ttttttattt tggccctttc     3240

aggagttgat tataaattgg tttgttttca agtcagaatt caagtgggca gaacccgtat     3300

tgtgaagacc taaactttcc taaatgttca tatgggtagc agattttgtg gtgattagaa     3360

acatcaggtc cttaaatacg atgaacatgg gatacaaagg aattctttat aagggcaagt     3420

atcctaagtt agcacattta cttttctctc ccctccgccc ccaaaagaaa aatccttaca     3480

aataaactgc aggtaggctt ctaagcctag tcctgcagta tgctgctaac atcttgatgc     3540

caatcttcac agcattcttt gattgtcatc ttattgctga tacattcata catatattta     3600

gtgcttgaca ctgtagaatt ttgttacaga agatggttac tagattttaa gggagctgag     3660

ggaataattg atgagccttg aattaaccat gcatttaatt agattttttg ttgttgttgt     3720

tgttgttttg agatgatgtc ttgctctgtt gcccaggctg gagtgcagtg gctcaatctc     3780

ggctcactgc aacctctgcc tcgcaggttt gagcgattct cctgtctcag cctccccagt     3840

agctgggttt acaggcgctt gccaccacac ctggctagat gttttatatt aaagccagag     3900

aattgaaaaa gaaatgcctc ctgtgattga aattatttta tagctcttag cccgttctac     3960

caaagatcac attagcagat tacccctccc tcctgtgata ttatctttct taaacctgaa     4020

ccaaatatca aaagatacaa gtttcatgat taggatgaaa tatatacata gggattttgg     4080

tttattgaag ttattgaaag acctagaaat tttctttttg agagaaaggg taaagaggtg     4140

agggttcatg tcacttaacc cctacccttt tgggcaaatt ttgtctcagg tagtgtttca     4200

ttccctaaat taatacctgt gcttccttgc ctctcacctt cccagttact tctttggggt     4260

attactgtgg cacattgtac acccagaaaa ggcacataca gtgattattt tgtgggaaat     4320

acttgattct tttgaaatat atttggaggg ggtagctagc tagccactgt caaaactaat     4380

gctgtattta caggacaaaa acaagtagag ttggacacct cagtaagaga cagcattaac     4440

taaaagtact gactgccttt taaaggaatt tttaaaacta ttctcttgca ataagagatc     4500

cgcatttatt accactggat gtcttccttt tttgtggcca ccaatatagc agctctcttt     4560

agagggattc cctttctgct atgccttgag ccaaactggc tgcttttaga acaaaaacca     4620

taagtatggt tttactcgaa cttctctttg tttttattga gagaaatatt gccttctttt     4680

tggtactcca gctgctaaag agtgctgaga tatgttaaat tattttttaa aagaaaatct     4740

ccaaatactt atttaacttg tcttctagat tcatgttgct tatattttaa ctattgagca     4800

agtttattat aaggaatgct gccatataga gaaagctgaa gagaaaccat gggcagaagg     4860

cttttttctg tcttattaca ctggaccttc actctggtaa gggcatcagt tacttttctg     4920

gaataaaagg cggagttaga gcacttatca gatgctgttt catggcttgt tttagttaat     4980

ttatcatgca gataactaac atttgggtat ctttttgttt taggtcttat tttctgactg     5040

ttaggcctat cttacacata agttctacta tcagtatact tggcagcatg actttttttt     5100

ttttttacag ttaatttaat gaaaatcagc accattgtaa atgatagtaa ttgtaacaac     5160

atagttactg ggtgaaggag taggggagac actcagtaac catctattta cctagacact     5220

tatgcagggg tacatgctag gtggctttat tcagattcgg gtacattgga atcacatcat     5280

gactttgagt ctgatggctg tgtagataaa gatttaagca agtgccttgt gtttgctgga     5340

aaatattaaa actcatttgg gtgaaagctt cccagatgat gataattaat agcacttctg     5400

cctttttcct ggagtaactt ttagattgag tcacatatga tagtataaaa gtccaaaatt     5460

ttctgggttt acctttgttt tatttttcat atatatattc actgtctgcc tggaaatagc     5520

cttggtttac cttatttttt tgtatatgta aaactattca tatttgattt tattccaata     5580

ttatatatga tggaaaagcc agaattgtct ggcagaattt aattcttcct tggatctcta     5640

gttctgtttt taatatcagg ttccttcatc aaattttact actgtagctc tgtgatataa     5700

tttcatttct tgtcaattat ggtcacatat agacaagtac ttggtcacaa ttagctcaaa     5760

agaatcccca tttcttaagg tgctcagtca atcaccttta ttttgagatg gtagtttttc     5820

aagttagtat tacttactag ctttcttgat gaatataaaa atgttgtctc catcatacag     5880

agctgagcct cttgtggtat attaagataa gtcccattct taatcacaga agaacatgga     5940

tattttagtt tttggagtac ccagaattgt aaagattttg tttcattttg ttttaggata     6000

gcttctctgc ctaatactat aggatatgtc atgttcgtta ttgtagccac ctccctcaga     6060

tgtttttcac tatttttaaa ttatataatg accagtagat tcacagtagc atgtacttga     6120

caagtgccat ggatatttaa gaagaaggta aataatttta atattttttg ctgtaatttt     6180

ataggagcag tggactgtaa gagaaatatc tataaatcag agagtattta ggaaactttg     6240

tattttatag gtggtcatta aagtgatctt caggatataa gatagtttac acaaacttta     6300

ttctcctgat aggaaatttt tattcatttt cctaccactc agcacttttg ttctgccttg     6360

tactgcttat gaggattaat gttttaaatt tgctttattt gtgcttttca gagagttgtc     6420

ataattgtgg cagttgtgtt tgtggcactg taaatgctga aattcatggg aaacttacca     6480

aatgactgct tgagtgttat ttcccattaa attgggtagc tgtcacaata accagaagaa     6540

atcttgtggc ccttttgaag aaagccatgt atgttttgtt acctaggttc atagtatttt     6600

aatttaaagg caaagagaag cattctactt atttgtctta taaaccatta atcgtttttt     6660

gtgcagaaga gagcttattt tgttatactg ctttgtataa tggaaataag tcacattctg     6720

ggggaaaaaa actggaattg tttgtatttt gtttttttgg ggggggatct ttatgtgaaa     6780

aatcagagct acttgttacc ataagccctt actatcaaca agataattat ttgtaatcac     6840

ttttttatcc caggttggaa ttgctttccc cttctaagtt atcttccctt aataatattt     6900

atgataccag gacagtgagg gtataagagc aaatgtagtg aggtattcaa aaatcctgca     6960

tatatggact caaaagttct ttagttattt gaattatata tagctatatt attttattag     7020

cttgggttgt cagaagattg ccaattttaa gagtaaagag gagagagata agtaataaaa     7080

atagaggagg ggaagaaaat ggctccctta ctggtcttag taatcttcta tatagttaat     7140

gagctaaaaa atgatactta aagttccagg tttggtaccg ctagcataga aacattgcct     7200

ttcctacaca ttcctcatca ttgtttcctc agaaaattat tttaagagtt tgtgaaacca     7260

gattaaatat ctatattcag tttggcctaa tttttaaaaa taaatattta tactccagct     7320

tttgtgtatt tggtgtacat caccacttat gcaaatcaag gatcagaaaa ctggaggtta     7380

gccatctcca ttatttcctt ttgcacattg ggtacagtgg gtggcattag tatgcactag     7440

ctgcaaagtc acagcacctt atggaaataa gtatgtttat tataataaaa aaaagttaag     7500

ctgcatctct gtagattatt tactttgcag actgtaaagc tgccctatct tttccagcag     7560

aatttactct tccattctta attctttttt gaaatatctt aaataattta acattccttt     7620

ataacttctt aacagtgtca aaactggggt agaagggatt ttattttttc ccaaaagggt     7680

tccatctttg ctatctgttg atcagcctta gaaaatctaa gtatgatcaa taaattttaa     7740

tggttgatgg catcctgtgt cagctggagt agttggttgt gaatattaaa acctagtact     7800

attttccctc agtaacatgt aattgctaca ttttttataa gaaggtatgg ttagaaaaaa     7860

atgtgaaaga tcacttaaac caaagccagt tacaaggagt aatctctcct gttggtttac     7920

cttcacctca gaactacaag aatattacaa tacatagtga atagttgtct gtaacatttc     7980

taccagttgt ttcagtagca tattggtctt ggcatttctt ggcactgtgg ttctgctgta     8040

ttatttgtga tgtcttattg tttgtgagct tttgtttttt ttttaaagaa aaaacaaaaa     8100

ctaagtggga ctatgtatgt agatgtgtgt cagtaccaaa aagttatttt ctcaaatccc     8160

taaatttctg atttccattc aagtctttta aactctttcc tgctgaatag caaagaactt     8220

ttattttcca ctttcctata ttcctaaaaa gtgtgaacaa tgcgtttcag ttgactgtat     8280

tgcatacttt tttgctgaag actttttctg taaacacaat tgccttgttc agttttgttg     8340

taaactgact taccataaga tgcactgttg ataatgcttt ctgatgtgtg tttgataaga     8400

gtgataaaat aaaagcttaa aaataaagga gttgcttttt aatttc                    8446


<210> 4259
<211> 2327
<212> DNA
<213> Homo sapiens

<400> 4259
agcagagcta ccagctgccc tgttggcttc gctggtcgga tcgtcctcct ggccccgcca       60

aacaggcggg gggagcggcc ccgactgtgg ggccatggca gtagtctcct cgttcgccgc      120

cgccgctagc ctagctgagt cgccggcttc tgcgctaggg gctcccaccg cctccgcagg      180

ctaaggagcc gctgccacca acgagctgtg agggttacta tgctccctct ttgccgccgt      240

ctcctcctct tgcccgcgca ggcacccctc tggctgctca gtcctgcctc aggtacgaca      300

ccgagcttct ggtcaggtga tggctcttaa gatgaacaca ttgagcagta accgggcaaa      360

catgctgaaa gaagtacagc tcatgaatag actctcccat cccaacatcc ttaggttcat      420

gggtgtatgt gttcatcaag gacaattgca tgcacttaca gagtatatca actccgggaa      480

cctggaacag ttgctagaca gtaacctgca tttgccttgg actgtgaggg taaaactggc      540

ctatgacata gcagtgggcc tcagctacct tcacttcaaa ggcatttttc atcgggacct      600

cacatctaag aactgcctga taaagaggga tgagaatggt tactctgcag tggtagctga      660

ctttggcctg gctgagaaga tccccgatgt cagcatgggg agtgagaagc tggccgtggt      720

gggttcccca ttctggatgg cacctgaggt tctccgagat gagccctata atgaaaaggc      780

agatgtgttc tcttatggta tcatcctctg cgagatcatc gcccgcatcc aggccgatcc      840

ggactatctt ccccgcacag agaatttcgg gctggactat gatgctttcc agcacatggt      900

gggagactgt cccccagatt ttctgcaact tactttcaac tgctgtaaca tggatcccaa      960

actgcgccca tcttttgtgg agattgggaa gaccctggag gaaattctga gccgcctaca     1020

ggaagaagag caggagaggg ataggaagct gcagcccaca gccaggggac tcttggagaa     1080

agcacctggg gtgaagcgac taagctcact ggatgacaag atcccccaca agtcaccatg     1140

cccaagacgt accatctggc tgtctcgaag ccagtcagat atcttttccc gtaagccccc     1200

acgtacagtg agtgtcttgg acccatacta ccggccacga gatggtgctg cccgcacccc     1260

caaagtcaac ccttttagtg ctcgccagga cctcatgggg ggcaagatca agttttttga     1320

cctgcccagc aagtctgtca tctctctggt atttgacctg gatgcaccag ggcccggaac     1380

tatgcccctg gctgactggc aggagcccct ggccccacct attcgccggt ggcgttcctt     1440

gcctggttcg cctgagttct tgcatcaaga ggcttgtcca tttgtgggcc gggaagaatc     1500

gctatctgat gggcccccac cacgcctaag tagtctcaag tacagagtta aagagatccc     1560

accattccgg gcatctgccc taccagctgc tcaagcccat gaggctatgg actgctccat     1620

tctccaggaa gaaaatggtt ttgggtccag gccccagggg accagtccat gccctgcggg     1680

tgcttctgag gagatggagg tagaagaaag gccagcaggc tcaactccag ccaccttctc     1740

cacctcaggc ataggcctgc aaacccaggg aaagcaggat gggtgagggg gtttagtccc     1800

tgcctcacct tggggatgga ccttcagctg aaaccatatg gccccctagg tgcacagcct     1860

tgattcttcc ctggagccta cagagcaggc aggctaggcc aagccaggct caacttctgg     1920

gctcccagtg cccattggct gtgtatgacg ggaggcagca gtgagaggcc ttcctagtta     1980

gggccaacag ctgataccaa gcctctgaaa tccagcaagg aggtctgcct cccaccagac     2040

cctctccagt gtacttcccc agataggacc agaggatgtc tagttctagg ctgagctggc     2100

aggcagctat taccccggtt ctttccccac cccaggtctg tctcttgcct tttcttgggg     2160

catataagct actgagtgga acatggagct gatcaagagg ccgtaatggt catggctgtt     2220

tcccagacct gaatattggg gtgcttcttg ccagtattct aagacatttg agtaattgct     2280

gtttgcactt actgcatggt cagaccacgt cactacattt ctatgca                   2327


<210> 4260
<211> 2099
<212> DNA
<213> Homo sapiens

<400> 4260
agcagcgggt tagtggtcgc gcgcccgacc tccgcagtcc cagccgagcc gcgacccttc       60

cggccgtccc caccccacct cgccgccatg cgcctccgcc gcctagcgct gttcccgggt      120

gtggcgctgc ttcttgccgc ggcccgcctc gccgctgcct ccgacgtgct agaactcacg      180

gacgacaact tcgagagtcg catctccgac acgggctctg cgggcctcat gctcgtcgag      240

ttcttcgccc cctgttccat tcctgctgga tttgaagagg agagtctcct ccagcctcat      300

tgaaactctt tttgtggatt tgatgacctt atggatattg ccaaagttta aggcagtgga      360

ttttagtccc agccttgcag cttacacaca cacctggttg ctccccagat ttctggagat      420

tctcattcag tgtggacact gcaagagact tgcacctgag tatgaagctg cagctaccag      480

attaaaagga atagtcccat tagcaaaggt tgattgcact gccaacacta acacctgtaa      540

taaatatgga gtcagtggat atccaaccct gaagatattt agagatggtg aagaagcagg      600

tgcttatgat ggacctagga ctgctgatgg aattgtcagc cacttgaaga agcaggcagg      660

accagcttca gtgcctctca ggactgagga agaatttaag aaattcatta gtgataaaga      720

tgcctctata gtaggttttt tcgatgattc attcagtgag gctcactccg agttcctaaa      780

agcagccagc aacttgaggg ataactaccg atttgcacat acgaatgttg agtctctggt      840

gaacgagtat gatgataatg gagagggtat catcttattt cgtccttcac atctcactaa      900

caagtttgag gacaagactg tggcatatac agagcaaaaa atgaccagtg gcaaaattaa      960

aaagtttatc caggaaaaca tttttggtat ctgccctcac atgacagaag acaataaaga     1020

tttgatacag ggcaaggact tacttattgc ttactatgat gtggactatg aaaagaacgc     1080

taaaggttcc aactactgga gaaacagggt aatgatggtg gcaaagaaat tcctggatgc     1140

tgggcacaaa ctcaactttg ctgtagctag ccgcaaaacc tttagccatg aactttctga     1200

ttttggcttg gagagcactg ctggagagat tcctgttgtt gctatcagaa ctgctaaagg     1260

agagaagttt gtcatgcagg aggagttctc gcgtgatggg aaggctctgg agaggttcct     1320

gcaggattac tttgatggca atctgaagag atacctgaag tctgaaccta tcccagagag     1380

caatgatggg cctgtgaagg tagtggtagc agagaatttt gatgaaatag tgaataatga     1440

aaataaagat gtgctgattg aattttatgc cccttggtgt ggtcactgta agaacctgga     1500

gcccaagtat aaagaacttg gcgagaagct cagcaaagac ccaaatatcg tcatagccaa     1560

gatggatgcc acagccaatg atgtgccttc tccatatgaa gtcagaggtt ttcctaccat     1620

atacttctct ccagccaaca agaagctaaa tccaaagaaa tatgaaggtg gccgtgaatt     1680

aagtgatttt attagctatc tacaaagaga agctacaaac ccccctgtaa ttcaagaaga     1740

aaaacccaag aagaagaaga aggcacagga ggatctctaa agcagtagcc aaacaccact     1800

ttgtaaaagg actcttccat cagagatggg aaaaccattg gggaggacta ggacccatat     1860

gggaattatt acctctcagg gccgagagga cagaatggat ataatctgaa tcctgttaaa     1920

ttttctctaa actgtttctt agctgcactg tttatggaaa taccaggacc agtttatgtt     1980

tgtggttttg ggaaaaatta tttgtgttgg gggaaatgtt gtgggggtgg ggttgagttg     2040

ggggtatttt ctaatttttt ttgtacattt ggaacagtga caataaatga gaccccttt      2099


<210> 4261
<211> 3001
<212> DNA
<213> Homo sapiens

<400> 4261
aaagagcccg ctccgccgag cgccgggcga cggcaggaag cccctccgct tggccagaat       60

ggagcagccg aagggagttg attggacagt catcatcctg acctgccagt acaaggacag      120

tgtccaggtc tttcagagag aactggaagt gcggcagaag cgggagcaga tccctgctgg      180

gacgctgtta ctggccgtgg aggacccaga gaagcgtgtg ggcagcggag gagccaccct      240

caacgccctg ctggtggctg ctgaacacct gagtgcccgg gcaggcttca ctgtggtcac      300

atccgatgtc ctgcactcgg cctggatcct cattctgcac atgggtcgag acttcccctt      360

tgatgactgt ggcagggctt tcacctgcct ccccgtggag aaccccgagg cccccgtgga      420

agccttggtc tgcaacctgg actgcctgct ggacatcatg acctatcggc tgggcccggg      480

ctccccgcca ggcgtgtggg tctgcagcac cgacatgctg ctgtctgttc ctgcaaatcc      540

tggtatcagc tgggacagct tccggggagc cagagtgatc gccctcccag ggagcccggc      600

ctacgctcag aatcatggcg tctacctaac tgacccccag ggccttgttt tggacattta      660

ctaccagggc actgaggcag agattcagcg gtgtgtcagg cctgatgggc gggtgccact      720

ggtctctggg gttgtcttct tctctgtgga gactgccgag cgcctcctag ccacccacgt      780

gagcccgccc ctggatgcct gcacctacct aggcttggac tccggagccc ggcctgtcca      840

gctgtctctg ttttttgaca ttctccactg catggctgag aacgtgacca gggaggactt      900

cctggtgggg aggcccccag agttggggca aggcgatgca gatgtagcgg gttatctgca      960

gagcgcccgg gcccagctgt ggagggagct tcgcgatcag ccccttacca tggcctatgt     1020

ctccagcggc agctacagct acatgacctc ctcagccagt gagttcctgc tcagcctcac     1080

actccccggg gctcctgggg cccagattgt gcactcccag gtggaggagc agcagcttct     1140

ggcggccggg agctctgtgg tcagctgcct gctggagggc cctgtccagc tgggtcctgg     1200

gagcgtcctg cagcactgcc acctgcaggg ccccattcac ataggcgctg gctgcttggt     1260

gactggcctg gatacagccc actccaaggc cctgcatggc cgggagctgc gtgaccttgt     1320

cctgcaggga caccacacgc ggctacacgg ctccccgggc cacgccttca ccctcgttgg     1380

ccgtctggac agctgggaga gacagggggc aggcacatat ctcaacgtgc cctggagtga     1440

attcttcaag aggacaggtg ttcgagcctg ggacctgtgg gaccctgaga cgctgcccgc     1500

agagtactgc cttcccagcg cccgcctctt tcctgtgctc cacccctcga gggagctggg     1560

accccaggac ctgctgtgga tgctggacca ccaggaggat gggggcgagg ccctgcgagc     1620

ctggcgggcc tcctggcgcc tgtcctggga gcagctgcag ccgtgcctgg atcgggctgc     1680

cacgctggcc tctcgccggg acctgttctt ccgccaggcc ctgcataagg cgcggcacgt     1740

gctggaggcc cggcaggacc tcagcctgcg cccgctgatc tgggctgctg tccgcgaggg     1800

ctgccccggg cccctgctgg ccacgctgga ccaggttgca gctggggcag gagaccctgg     1860

tgtggcggca cgggcactgg cctgtgtggc ggacgtcctg ggctgcatgg cagagggccg     1920

tgggggcttg cggagcgggc cagctgccaa ccctgagtgg atgcggccct tctcatacct     1980

ggagtgtgga gacctggcag cgggcgtgga ggcgcttgcc caggagaggg acaagtggct     2040

aagcaggcca gccttgctgg tgcgagcggc ccgccactat gagggggctg gtcagatcct     2100

gatccgccag gctgtgatgt cagcccagca ctttgtctcc acagagcagg tggaactgcc     2160

gggacctggg cagtgggtgg tggctgagtg cccggcccgt gtggatttct ctgggggctg     2220

gagtgacacg ccaccccttg cctatgagct tggcggggct gtgctgggcc tggctgtgcg     2280

agtggacggc cgccggccca tcggagccag ggcacgccgc atcccggagc ctgagctgtg     2340

gctggcggtg gggcctcggc aggatgagat gactgtgaag atagtgtgcc ggtgcctggc     2400

tgacctgcgg gactactgcc agcctcatgc cccaggggcc ctgctgaagg cggccttcat     2460

ctgtgcaggg atcgtgcatg tccactcgga actccagctg agtgagcagc tgctccgcac     2520

cttcgggggc ggctttgagc tgcacacctg gtctgagctg ccccacggct ctggcctggg     2580

caccagcagc atcctggcag gcactgccct ggctgccttg cagcgagccg caggccgggt     2640

ggtgggcacg gaagccctga tccacgcagt gctgcacctg gagcaggtgc tcaccactgg     2700

aggtggctgg caggaccaag taggtggcct aatgcctggc atcaaggtgg ggcgctcccg     2760

ggctcagctg ccactgaagg tggaggtaga agaggtcacg gtgcctgagg gctttgtcca     2820

gaagctcaat gaccacctgc tcttggtgta cactggcaag acccgcctgg ctcggaacct     2880

gctgcaggat gtgctgagga gctggtatgc ccgacttcct gctgtggtgc agaatgccca     2940

cagcctggta cggcaaactg aggagtgtgc tgaaggcttc cgccaagggt ctcacattta     3000

g                                                                     3001


<210> 4262
<211> 1816
<212> DNA
<213> Homo sapiens

<400> 4262
gtggggcgca tggagggctg ctcttcacct atcgtggtga agtttgctga cactcagaag       60

gacaaagagc aaaggcgcct ccagcagcag ctcgctcagc agatgcagca gctcaacact      120

gccacctggg ggaacctgac agggctgggc ggactgaccc cacagtatct ggcgctcctg      180

cagcaggcca cctcctccag caacctgggt gcgttcagcg gcattcaaca aatggcaggc      240

atgaatgctt tacagttgca gaacctggcg acgctggctg ctgctgcagc tgcggcccag      300

acctcagcca ccagcaccaa tgcaaaccct ctctctacca cgagcagcgc cctgggagcc      360

ctcacgagtc ccgtggctgc ttcaaccccc aactccactg ctggtgcagc catgaactcc      420

ttgacctctc tcgggactct gcaaggactg gctggagcca ctgttggact gaataatatt      480

aatgcactag caggtatggc ggctctgaat ggaggacttg gcgccacagg cttgacgaat      540

ggcacggctg gcaccatgga cgccctcacc caggcctact caggaattca acagtacgca      600

gccgccgcgc tgcccactct gtacagccag agcctgctgc agcagcagag cgctgcaggc      660

agccagaagg aaggtccaga gggggcaaac ctctttattt accaccttcc acaggaattt      720

ggagaccagg acattctgca gatgttcatg ccttttggaa atgttatctc tgctaaagtc      780

ttcattgaca aacagaccaa tctgagcaag tgctttggtt ttgttagcta cgacaatcca      840

gtctctgcac aagctgctat ccaagctatg aatggctttc agatcggcat gaaacgcttg      900

aaggtgcagc tgaagcgttc caaaaacgac agcaaacctt actgatccta accccagagg      960

ctccctgctc tcattttagc tttcttagga catcttcatg cccgttagtt catcgtttgc     1020

ctagcatgtc cctgtggcgt ctcaaaaaaa agtttcatcg tcccgtcatt gtttctgatg     1080

tctttctgac ctcacatcat atttggttct cctactgacc tttgatctag tttgaccttt     1140

gaaatttgca tgtgacctca tctagctatg aattctggga agtcaatgtg aaaaacattg     1200

ctgcattcat gcaagactga aatttattat tagacaaatt cattatagaa aaaacctgtg     1260

gcaaaaacgt ttctttctta ttttttttct tttcctaaaa cagacttgaa agtattatac     1320

agggattggc attcttcccg gtcactggta acaatagcaa tatgtgtcca gggacacaga     1380

atgttggttt ctaacagact acttccaaaa acagtttgag aaaaaaactg tctgatttta     1440

agtctctaga ggtctgtaat agtttttaca tttttcaggc agtgtaaagt tttttgataa     1500

ggccatttta ggtggctcac tttctcatta agatatatat atagaaccac tttttgtaga     1560

ttagtataag aaaaatattt accctgtttt ggggcaaatg ctacctattt gtgtcacctt     1620

ttgctgaact cacagttaga caatccatgg tttaatgcac atgaaattac ctatatttta     1680

tactgtttca atgtacagga gaaaggttac tgtaaactgt gttatgttgg tgcttctgtg     1740

aattaagttg tggtttcatc atgagtctta atgttctttg ttgataagac aagtttagaa     1800

ttggtttact taatac                                                     1816


<210> 4263
<211> 3086
<212> DNA
<213> Homo sapiens

<400> 4263
agcatggaaa agacttatac aagcactagc aacaactcta tatctggatc attgaagcgc       60

ttggaagata ctactgcacg atttacaaat gcaaatttcc aggaagtctc tgcacacacc      120

tctagtggaa aagatgtttc agagactaga gggtcagagg gcaaagggaa gaaatcttca      180

gctcacagct caggtcaaag gggaagaaag cctggtggtg gaagaaatcc aggaacaact      240

gtgtcagcag ctagcccttt tcctcaagca ggatataagc gggctcaaac ttctggcata      300

gaagaagaaa ctgtaaagga aaagaaaagg aaaggaaata aacaaagtaa gcatgggcct      360

ggcagaccca aaggaaacaa aaatcaagag aatgtttctc atctctcagt ttcttctgct      420

tcaccaacat catctgtagc atcagctgca ggaagcataa caagctctag tctgcagaaa      480

tctcctacat tgctcaggaa tggaagttta cagagcctca gtgttggctc atctccagtt      540

ggttcagaaa tttccatgca gtatcggcat gatggagctt gcccaacaac tacgttctca      600

gagttgctga atgcaataca caacgacaga ggtgacagtt ctacactaac aaagcaagaa      660

cttaaattca taggtattta taacagcaat gatgtagcag tatcgtttcc aaatgtagta      720

tctggctcgg gatctagtac tcctgtctcc agctctcact tacctcagca gtcttctggg      780

catttgcaac aagtaggagc gctctctccc tcagctgtgt catctgcagc ccctgctgtt      840

gctacaactc aggcaaatac tctatctgga tcttctctca gtcaggcacc atctcatatg      900

tatggcaata gatcaaattc atcaatggca gctcttatag ctcagtctga aaacaatcaa      960

acagatcaag atcttggaga caatagccgc aacctagttg gcagaggaag ctcaccccga     1020

ggaagtctct cgccacgatc ccctgtaagc agcttacaga ttcgctatga tcaaccaggc     1080

aacagcagtt tggaaaatct gcctccagta gcagccagca tagaacagct tttggagagg     1140

cagtggagtg aaggacagca atttttacta gaacagggta ctcctagtga cattttagga     1200

atgctgaagt cattacacca acttcaagtt gaaaaccgaa gattagagga acaaattaaa     1260

aacttgactg ccaaaaagga acggcttcag ttattgaatg cacagctttc agtgcctttt     1320

ccaacaataa cagcaaatcc tagtccgtct catcaaatac acacattttc agcacagact     1380

gctcctacta ctgattcctt gaacagcagt aagagccctc atataggaaa cagcttttta     1440

cctgataatt ctcttcctgt attaaatcag gacttaacct ccagtggaca aagtaccagc     1500

agctcatcag ctctttctac cccacctcct gctgggcaga gtccggctca acaaggctca     1560

ggagtgagtg gagttcagca ggtcaatggc gtgacagtgg gggcactagc tagtggaatg     1620

cagcctgtaa cttccaccat tcctgccgtg tctgcagtgg gtggaataat tggagctttg     1680

ccaggtaacc aactggcaat taatggcatt gtaggagctt taaatggggt tatgcagact     1740

cctgtcacaa tgtcccagaa ccctacccct ctcacccaca caaccgtacc acctaatgca     1800

acacatccaa tgccagctac actgactaac agtgcctcag gactaggatt actttctgac     1860

cagcaacgac aaatacttat tcatcaacag cagtttcagc agttgttaaa ttctcaacag     1920

ctcacaccag aacaacatca agcctttttg tatcagttaa tgcaacatca ccaccagcag     1980

caccaccaac ctgaacttca gcagctgcag atccctggac caacacaaat acccataaac     2040

aaccttcttg caggtacaca ggcaccccca cttcacacag ctaccaccaa cccatttctc     2100

accatccatg gagataatgc aagtcagaaa gtagcaagac ttagtgataa aactgggcct     2160

gtagctcaag agaaaagttg acacctgaga aacatctaga aattgcctat cctgctgttc     2220

tagcacttca tctggctgcc tttgcagtcc ttttactaca gctatgaaga aacgcaacaa     2280

gaaactcaat gcacaacaaa ggattaattg ctgcaaggac attcttgtaa ggctttgatt     2340

agttttcttg ttgctttgtt gcactgaaat ggaattccca tgcccctacc ccttacccca     2400

gttttttgaa catggaaaga aaatttaata actttttaaa gtgacataat ttacatgcaa     2460

tatgtttatc aactcaagaa tttaatatag ttggtacaca actagttttg tttataaatt     2520

ggagatgcaa atagcaaaac taaatacttg ctccatttac aaactacttg attttattgt     2580

acaagttgaa atatgctctt ttgtttgggt tacagtatgc ttgctctaag tcaaattcca     2640

aggaactaat ttcttctcct ggagttgcat tgattcagta ttacaaatat atagcacatc     2700

acctgggact tggcaatctt tgttaaaaaa aaatttcctt tctaatggga tttggccaat     2760

tttggtaatg aagttaggat ggtaatgtct gcatctgcta aaggtaattt tcttttgaga     2820

attgctttct ttagtgttaa gacctactca tattttgaag aaatcttgag ttaagtgagt     2880

tctgaggctg ctgggggaac cagatcaatt caaagctaaa tacttctttc agaaaggggc     2940

cactgtggaa agtgctggtg gggtttgccc ttgatcaagt gcctccattg tgctgcaagg     3000

gctgtagaca gcagggtggg acagtcagtc ctccgagcag caggaatcat cccgtcacct     3060

gcagccttcc catgcttccg ccttta                                          3086


<210> 4264
<211> 2476
<212> DNA
<213> Homo sapiens

<400> 4264
gtgcggaggg gcggggcgtg tggaggccgg gacggcgccc ccggccggcg gtgaggccgg       60

ctcagcgcgg agcagctcag tgccccccgc gccccgctcc ggcagctcca cgctcgcgcc      120

cgccatgccg gagcagttca gcgtcgccga gttcctggcc gtcaccgcgg aggacctcag      180

ctccccggct ggggccgccg ccttcgccgc caagatgccc cggtaccgag gggcggcgct      240

ggcgcgggag gagatcttgg aaggagacca agccatcctg cagagaataa agaaggctgt      300

gcgggcaatc catagctccg gccttggcca tgtggagaat gaagagcagt accgagaggc      360

cgtggaatcc ttaggcaaca gccacctgtc ccagaacagc catgagctgt ccacaggctt      420

cctaaacttg gccgtgttca cccgcgaggt tgctgcgctc ttcaagaacc tgattcagaa      480

cttgaacaac attgtctctt tccccctgga cagtctgatg aaggggcagc tgagggacgg      540

tcgacaggat tccaaaaaac agctggagaa ggcatggaag gactatgaag ccaaaatggc      600

caagctggag aaggagcgcg atcgggccag ggtgacagga gggatccctg gggaggtggc      660

ccaggacatg cagagagagc ggcgcatctt ccagctgcac atgtgtgagt atctgctcaa      720

agccggggag agccagatga agcaaggtcc tgacttcctt cagagcctca tcaagttctt      780

ccacgcccag cacaactttt tccaagatgg ctggaaggct gcccagagcc tgttcccctt      840

catcgagaag ctggcggcct cagtacatgc actccatcag gcccaggagg acgagctaca      900

gaagctgacc cagctccggg actccctccg agggacactg cagcttgaga gcagagagga      960

acacctgagc cggaagaact caggatgtgg ctatagcatc caccagcacc aaggcaacaa     1020

gcagtttggg acggagaaag tgggctttct atacaagaaa agtgacggaa ttcgaagagt     1080

ctggcagaaa aggaagtgtg gagtcaagta tggctgcctg accatctcac acagcacgat     1140

aaaccggccc ccggtgaagc tgaccctgct gacgtgccaa gtgaggccaa accctgagga     1200

gaaaaagtgc ttcgacctgg tgacccacaa ccggacgtac cactttcagg cagaggacga     1260

gcacgagtgt gaggcgtggg tgtcagtgtt gcagaacagc aaggacgaag ccctgagcag     1320

cgccttcctc ggggagccca gcgctggccc ggggtcctgg gggtccgccg gccatgatgg     1380

ggagccgcac gacctcacaa agctgctcat cgcggaggtg aagagcaggc ctgggaatag     1440

ccagtgctgc gactgcgggg ctgcagaccc cacgtggctc agcaccaacc tgggcgtgct     1500

cacctgcatc cagtgctcgg gcgtccaccg cgaactgggc gtgcgctttt cgcgcatgca     1560

gtcactcacc ttggacctgc tgggcccctc cgagttgttg ctggccttga acatgggaaa     1620

cacgagcttc aatgaggtca tggaggccca gctaccctca cacggcggcc ctaaaccctc     1680

agctgagagt gacatgggca cccgcaggga ctacattatg gccaagtatg tggagcatag     1740

gtttgcacgc cggtgcacac ctgagcctca gcgactctgg acagccattt gcaacaggga     1800

cctcctgtcg gtactggagg cctttgccaa tgggcaggac tttggacagc cgctgccagg     1860

gcctgatgca caggcacctg aagaactcgt cttgcatttg gctgtcaaag tcgccaacca     1920

ggcttccctg cctctggtgg atttcatcat ccagaacggt ggtcacctgg atgccaaggc     1980

tgctgacggg aacacggctc tgcactacgc agcactctac aaccagcccg actgcctcaa     2040

gctgctgctg aaggggagag ctttggttgg cacagtaaat gaagcaggcg agacagctct     2100

ggacatagcc aggaagaagc accacaagga gtgtgaggag ctgctggagc aggcccaggc     2160

ggggaccttt gccttccctc tacatgtgga ctactcctgg gtaatttcca cagagcctgg     2220

ctctgacagt gaggaggatg aggaagagaa gcgctgcttg ctgaagctcc cggcccaggc     2280

tcactgggcc agtgggaggc tggacatcag caacaagacc tatgagactg tcgccagcct     2340

gggagcagcc acccctcagg gcgagagtga ggactgtccc ccgcccttgc cagtcaaaaa     2400

ctcttctcgg actttggtcc aagggtgtgc aagacatgcc agtggagggc ggagggagga     2460

gcgggctcgg cgggag                                                     2476


<210> 4265
<211> 5175
<212> DNA
<213> Homo sapiens

<400> 4265
cccatctcta cgaaaaatac aaaaattagc caagtatggt ggccggcgcc tgtaatccca       60

gctactcggg agactgaggc agagaactgc ttgaacctgg gaggcagagg ttgcagtgat      120

ccgagatcgc gtcactgcac tccagcgtgg gcgacagagc gagactccgt ttcagaaaag      180

aaaaaaaaaa aaaaaaaaaa gggagtcggg gtggagctct cattggctcg ttgcatgtga      240

gtgtccctac ggcctagaaa tacaagagaa gcacatcgga acgggctgga aatccaccca      300

gttaactaga gggctttgaa ccttttatta acttggaggt tgactctcct gtcaactcga      360

ttcccttttg gctgtttggc agggtcagtg agacatcccc tgggtcgctc gaccccgtag      420

gacggttcag ggagccctcc aggtcttcgt ttctcctctt ccccgcacag tgctgttatc      480

cagctggggg atccaacgca cacttaaggc tccagcaaag tggctccgct gccggatggg      540

agtgccccag tgtgctggat gaagctggcg catgcaccat gtcatcatgt gtctctagcc      600

agcccagcag caaccgggcc gccccccagg atgagctggg gggcaggggc agcagcagca      660

gcgaaagcca gaagccctgt gaggccctgc ggggcctctc atccttgagc atccacctgg      720

gcatggagtc cttcattgtg gtcaccgagt gtgagccggg ctgtgctgtg gacctcggct      780

tggcgcggga ccggcccctg gaggccgatg gccaagaggt cccccttgac acctccgggt      840

cccaggcccg gccccacctc tccggtcgca agctgtctct gcaagagcgg tcccagggtg      900

ggctggcagc cggtggcagc ctggacatga acggacgctg catctgcccg tccctgccct      960

actcacccgt cagctccccg cagtcctcgc ctcggctgcc ccggcggccg acagtggagt     1020

ctcaccacgt ctccatcacg ggtatgcagg actgtgtgca gctgaatcag tataccctga     1080

aggatgaaat tggaaagggc tcctatggtg tcgtcaagtt ggcctacaat gaaaatgaca     1140

atacctacta tgcaatgaag gtgctgtcca aaaagaagct gatccggcag gccggctttc     1200

cacgtcgccc tccaccccga ggcacccggc cagctcctgg aggctgcatc cagcccaggg     1260

gccccattga gcaggtgtac caggaaattg ccatcctcaa gaagctggac caccccaatg     1320

tggtgaagct ggtggaggtc ctggatgacc ccaatgagga ccatctgtac atggtgttcg     1380

aactggtcaa ccaagggccc gtgatggaag tgcccaccct caaaccactc tctgaagacc     1440

aggcccgttt ctacttccag gatctgatca aaggcatcga gtacttacac taccagaaga     1500

tcatccaccg tgacatcaaa ccttccaacc tcctggtcgg agaagatggg cacatcaaga     1560

tcgctgactt tggtgtgagc aatgaattca agggcagtga cgcgctcctc tccaacaccg     1620

tgggcacgcc cgccttcatg gcacccgagt cgctctctga gacccgcaag atcttctctg     1680

ggaaggcctt ggatgtttgg gccatgggtg tgacactata ctgctttgtc tttggccagt     1740

gcccattcat ggacgagcgg atcatgtgtt tacacagtaa gatcaagagt caggccctgg     1800

aatttccaga ccagcccgac atagctgagg acttgaagga cctgatcacc cgtatgctgg     1860

acaagaaccc cgagtcgagg atcgtggtgc cggaaatcaa gatcctggtg aagaccatga     1920

tacgtaaacg ctcctttggg aacccattcg agggcagccg gcgggaggaa cgctcactgt     1980

cagcgcctgg aaacttgctc acgaagcaag gcagcgaaga caacctccag ggcaccgacc     2040

cgccccccgt gggggaggag gaagtgctct tgtgagaggc agtccctgcg tggaaagttg     2100

ctgggccccc gcccccggct cccccgcacg catgcatcca ctgcggccgg aggaggccat     2160

ggagcccgag tagctgcctg gatcgctcga cctcgcatgc gcgccgcgtc gcctctgggg     2220

ggctgctgca ccgcgtttcc atagcagcat gtcctacgga aacccagcac gtgtgtagag     2280

cctcgatcgt catctctggt tatttgtttt ttcctttgtt gttttaaagg ggacaaaaaa     2340

aaaaaaagga cttgactcca tgacgtcgac cgtggccgct ggctggctgg acaggcgggt     2400

gtgaggagtt gcagacccaa acccacgtgc attttgggac aattgctttt taaaacgttt     2460

ttatgccaaa aatccttcat tgtgattttc agaaccacgt cagatatacc aagtgactgt     2520

gtgtggggtt tgacaactgt ggaaaggcga gcagaaaact ccggcggtct gaggccatgg     2580

aggtggttgc tgcatttgag agggagtagg gggctagatg tggctcctag tgcaaaccgg     2640

aaaccatggc accttccaga gccgtggtct caaggagtca gagcagggct ggccctcagt     2700

agctgcaggg agctttgatg caacttattt gtaagaagga tttttaaatt ttttatgggt     2760

agaattgtag tcaggaaaac agaaagggct tgaaatttaa taagtgctgc tggaagggga     2820

ttttccaagc ctggaagggt attcagcagc tgtggtgggg aaacatttct cctgaaagac     2880

tgaacgtgtt tcttcatgac agctgctcaa agcaggtttc tgagatagct gaccgagctc     2940

tggtaaatct ctttgtcaaa ttacgaaaac ttcagggtga aatcctatgc ttccatgtac     3000

attacatggc ttaagattaa acaaaaacat ttttcaagtc tctaactaga gtgaactcta     3060

gagcacagta gttcagaaac tatttagagc ttccaggata tatttcacag cttcaggcat     3120

gtgatcagtt agagccgatg aaacctatgc ccgcctgtat atatattagc agcttagcta     3180

gttcataacc tgtatattct aaagactgct aaggttttgt tttcatttta aatcctagct     3240

gattgttgtg gtcaatgaaa tacccagttt ctggagggcc aggtgggaaa tgctttcact     3300

ggaccaacac acaaatgatc atcctgagga tctgagcttc cctagactcc acacaataac     3360

cttggggcac ccttttagag aagactgttg aaacccacag cactcgttgg ggtatgagga     3420

aaccagggct tggcacagga agttcccctt tgtagctaaa agtccagaaa gaaagggttc     3480

atctttttga cttccaactg atattgggaa gtttggttga ggttcaagtg tgactccttc     3540

cagagccaca ggtaggggag tgtgaagttg agggggagga aagctggaag gactctgcct     3600

tgggagattc ccagctctgc tttccagcgc ttggtggaat ctgggctggg gaaagacggc     3660

accgggaaac tctgcttccc cattgtttcc atctgatcag ctgtggtgtg aggacttctc     3720

agacaaaggc aaggcctcgt gcccctgccc agcccattca tggagccctg ggccttcttg     3780

gcttccatag atcctaagct cttgactgta gtttagccag acttgttttg ctatcttata     3840

agcagttcag aattagggaa tgctggtttt gaagagcaaa ggacaggtag tctagagagg     3900

gtcgtctggc ctgcttgctg ggtctttgta acccagcact tcctcttgcc ctcctggctt     3960

tatgtttatg gggagaggac tcaatagctc caccccttct ggcaccagat ggggcttggt     4020

tagtttgcaa taagcacctt gcagaggtta aagccagcgg gtccctagtc ttaggcccag     4080

cctgcttgtg tgggctctgg cctggcctgg tggctggccc agggggcagc agtgcttaga     4140

gcttctgcag ggcttctctt gtttacacag ctgcatcaga caatgccatt tctccccacc     4200

acggaacctt ccatctaaga tttcttccag ggaatgccag caatcaggca gcacccagct     4260

gtgggggcag tggggtgggg gagacccaca ttgatgactt tttttttttc ttttaatgaa     4320

gaaacaccaa agaaagctgt ggaaaggacc tgccccacat gaaaaggata agccaagatg     4380

gctgtaaaca cagagcattt gagctgccac tcttggagca cattgatttt tcaaaagcca     4440

gctctgtcag gaaaggaggt gctgttatga gcagctcttc cagtgggcaa agaggacgcc     4500

cataatttct tccattgcta gctcatctgt gggaccaatt tggtgtaagc aacctgtggc     4560

ctgcacttgt ggcctcgaag gaagcacaaa ccctccatcc acttcccatt tcctctgccc     4620

ttttccacct cccccttcca tcccaccagc tgccagtggc tcccagaaag ccttattgag     4680

ccccttgttg acacttgggg ctgcggaggc ctctccctac tggtctggcc tttcctgaga     4740

ggcaggtctt ccgtcctcag agcctttctg gaacaaggag aatgcctgtg caggtggaca     4800

cacaggcctg gcctgtcgct ctcacttgtc ttccagcggg gagcttcacg ttgccgagtg     4860

gaagaaccat gacctccact tgcttccaag gtgctaggga agtttcaggg tacgctggtt     4920

cccctctcca gctggaggcc gagtttctgg ggactgcaga tttttctact ctgtgatcga     4980

ttcaatgccc gatgcttctg tttcattccc gaccctttct actatgcatt ttccttttat     5040

caggtgtata aagttaaata ctgtgtattt atcactaaaa agtacatgaa cttaagagac     5100

aactaagcct ttcgtgtttt tccacaggtg tttaagcttc tctgtacagt tgaaataaac     5160

agacagcaaa atggt                                                      5175


<210> 4266
<211> 833
<212> DNA
<213> Homo sapiens

<400> 4266
gagcgccgga gcggacgccc ccagggagct ggggacaccc ccatgggaca gcccttcctg       60

gatctggaga gagcagctgc tgctgcccca ccacctgcca ggcccggcca ctgagcagcc      120

ccccggagcc ccagatcccc gttcccccca ggtggcctgg gaggtggccc cctcgaggat      180

gactccacta gcgccctggg accccaagta tgaagccaaa gcaggacctc ggccggtgtg      240

gggggccaac tgtagctcag gagcctcgtt ctcaggccgg acgctgtgtc acccctcatt      300

ctggccgctg tatgaagcag cctcgggcag gggtctcagg cccgtggccc ctgccacagg      360

gcactggaat ggacagcagg cgcccccaga tgcagggttc ccggtggtgt gctgtgaaga      420

tgtcttcctc tcggaccctc tgctgccccg ggggcagcgt gttcccctgt acctgtccaa      480

ggccccccag cagatgatgg gctccctgaa actgctgccg ccgcccccca tcatgtctgc      540

cagggtgctc ccccgcccat caccctcccg gggcccctcc actgcctggc tcagcgggcc      600

ggagctgatc gctctcactg gcctgctgca gatgagccag ggggagccta ggcccagctc      660

ctccgcggtt ggccccccag accatacctc tgacccaccc agcccctgtg gtagccccag      720

cagttctcag ggtgctgacc tctctctccc acagacccca gacacccatt gtccatagcc      780

ttctcagggc agagtgggct ggttgtgttg acaataaaac agtgttggtt tgc             833


<210> 4267
<211> 1785
<212> DNA
<213> Homo sapiens

<400> 4267
gctgggcggc ccggtctcgg agaagagggg agagtggcgg gccgctgaat aagcttccaa       60

aatgatgccc acaccagtta tcctattgaa agaggggact gatagctccc aaggcatccc      120

ccagcttgtg agtaacatca gtgcctgcca ggtgattgct gaggctgtaa gaactaccct      180

gggtccccgt ggcatggaca agcttattgt agatggcaga ggcaaagcaa caatttctaa      240

tgatggggcc acaattctga aacttcttga tgttgtccat cctgcagcaa agactttggt      300

agacattgcc aaatcccaag atgctgaggt gggtgatggc accacctcag tgaccttgct      360

ggctgcagag tttctgaagc aggtgaaacc ctatgtggag gaaggtttac acccccagat      420

catcattcga gctttccgca cagccaccca gctgggagca gaggaagctg ctggaaaagt      480

gtgccatgac cgctctgagc tccaagctga tctcccagca gaaagctttc tttgctaaga      540

tggtggtgga tgcagtgatg atgctcgatg atttgctgca gcttaaaatg attggaatca      600

agaaggtaca gggtggagcc ctcgaggatt ctcagctggt agctggtgtt gcattcaaga      660

agactttctc ttacgctggg tttgaaatgc aacccaaaaa gtaccacaat cccaagattg      720

cccttttgaa tgtcgagctc gagttgaaag ctgagaaaga caatgctgag ataagagtcc      780

acacagttga ggattatcag gcaattgttg atgctgagtg gaacattctc tatgacaagt      840

tagagaagat ccatcattct ggagccaaag ttgtcttgtc caaactcccc attggggatg      900

tggccaccca gtactttgct gacagggaca tgttctgtgc tggccgagta cctgaggagg      960

atctgaagag gacaatgatg gcctgtggag gctcaatcca gaccagtgtg aatgctctgt     1020

cagcagatgt gctgggtcga tgccaggtgt ttgaagagac ccagattgga ggcgagaggt     1080

acaatttttt tactggctgc cccaaggcca agacatgcac cttcattctc cgtggcggcg     1140

ccgagcagtt tatggaggag acagagcggt ccctgcatga tgccatcatg atcgtcagga     1200

gggccatcaa gaatgattca gtggtggctg gtggcggggc cattgagatg gaactctcca     1260

agtacctgcg ggattactca aggactattc caggaaaaca gcagctgttg attggggcat     1320

atgccaaggc cttggagatt atcccacgcc agctgtgtga caatgctggc tttgatgcca     1380

caaacattct caacaagctg cgggctcggc atgcccaggg gggtacatgg tatggagtag     1440

acatcaacaa cgaggacatt gctgacaact ttgaagcttt cgtgtgggag ccagctatgg     1500

tgcggatcaa tgcgctgaca gcagcctctg aggctgcgtg cctgatcgtg tctgtagatg     1560

aaaccatcaa gaacccccgc tcgactgtgg atgctcccac agcagcaggc cggggccgtg     1620

gtcgtggccg cccccactga gaggcacccc acccatcaca tggctggctg gctgctgggt     1680

gcacttaccc tccttggctt ggttacttca ttttacaagg aaggggtagt aattggccca     1740

ctctcttctt actggaggct atttaaataa aatgtaagac ttcag                     1785


<210> 4268
<211> 3438
<212> DNA
<213> Homo sapiens

<400> 4268
aagccttatt agagctttct caacctgcag ccctcatctc cgccggcgag tagggccagg       60

tgttgggagc tcccacgtgg gacaagatgg tgtcttcggc gcagatgggc ttcaacctgc      120

aggctctcct ggagcagctc agccaggatg agttgagcaa gttcaagtat ctgatcacga      180

ccttctccct ggcacacgag ctccagaaga tcccccacaa ggaggtagac aaggctgatg      240

ggaagcaact ggtagaaatc ctcaccaccc attgtgacag ctactgggtg gagatggcga      300

gcctccaggt ctttgaaaag atgcaccgaa tggatctgtc tgagagagca aaggatgaag      360

tcagagaagc agctttgaaa tcctttaata aaaggaagcc tctatcatta gcgtttacag      420

aaacgaaagg aaatgtcatc tgcctgggta aagaagtctt taaaggaaaa aagccagaca      480

aagacaatag gtgcaggtat atattgaaga cgaagttccg ggagatgtgg aagagctggc      540

ctggagatag caaagaggtc caggttatgg ctgagagata caagatgctg atcccattca      600

gcaaccccag ggtgcttccc gggcccttct catacacggt ggtgctgtat ggtcctgcag      660

gccttgggaa aaccacgctg gcccagaaac taatgctaga ctgggcagag gacaacctca      720

tccacaaatt caaatatgcg ttctacctca gctgcaggga gctcagccgc ctgggcccgt      780

gcagttttgc agagctggtc ttcagggact ggcctgaatt gcaggatgac attccacaca      840

tcctagccca agcacggaaa atcttgttcg tgattgacgg ctttgatgag ctgggagccg      900

cacctggggc gctgatcgag gacatctgcg gggactggga gaagaagaag ccggtgcccg      960

tcctcctggg gagtttgctg aacagggtga tgttacccaa ggccgccctg ctggtcacca     1020

cgcggcccag ggccctgagg gacctccgga tcctggcgga ggagccgatc tacataaggg     1080

tggagggctt cctggaggag gacaggaggg cctatttcct gagacacttt ggagacgagg     1140

accaagccat gcgtgccttt gagctaatga ggagcaacgc ggccctgttc cagctgggct     1200

cggcccccgc ggtgtgctgg atcgtgtgca cgactctgaa gctgcagatg gagaaggggg     1260

aggacccggt ccccacctgc ctcacccgca cggggctgtt cctgcgtttc ctctgcagcc     1320

ggttcccgca gggcgcacag ctgcggggcg cgctgcggac gctgagcctc ctggccgcgc     1380

agggcctgtg ggcgcagacg tccgtgcttc accgagagga tctggaaagg ctcggggtgc     1440

aggagtccga cctccgtctg ttcctggacg gagacatcct ccgccaggac agagtctcca     1500

aaggctgcta ctccttcatc cacctcagct tccagcagtt tctcactgcc ctgttctaca     1560

ccctggagaa ggaggaggaa gaggataggg acggccacac ctgggacatt ggggacgtac     1620

agaagctgct ttccggagta gaaagactca ggaaccccga cctgatccaa gcaggctact     1680

actcctttgg cctcgctaac gagaagagag ccaaggagtt ggaggccact tttggctgcc     1740

ggatgtcacc ggacatcaaa caggaattgc tgcgatgcga cataagttgt aagggtggac     1800

attcaacggt gacagacctg caggagctcc tcggctgtct gtacgagtct caggaggagg     1860

agctggtgaa ggaggtgatg gctcagttca aagaaatatc cctgcactta aatgcagtag     1920

acgttgtgcc atcttcattc tgcgtcaagc actgtcgaaa cctgcagaaa atgtcactgc     1980

aggtaataaa ggagaatctc ccggagaatg tcactgcgtc tgaatcagac gccgaggttg     2040

agagatccca ggatgatcag cacatgcttc ctttctggac ggacctttgt tccatatttg     2100

gatcaaataa ggatctgatg ggtctagcaa tcaatgatag ctttctcagt gcctccctag     2160

taaggatcct gtgtgaacaa atagcctctg acacctgtca tctccagaga gtggtgttca     2220

aaaacatttc cccagctgat gctcatcgga acctctgcct agctcttcga ggtcacaaga     2280

ctgtaacgta tctgaccctt caaggcaatg accaggatga tatgtttccc gcattgtgtg     2340

aggtcttgag acatccagaa tgtaacctgc gatatctcgg gttggtgtct tgttccgcta     2400

ccactcagca gtgggctgat ctctccttgg cccttgaagt caaccagtcc ctgacgtgcg     2460

taaacctctc cgacaatgag cttctggatg agggtgctaa gttgctgtac acaactttga     2520

gacaccccaa gtgctttctg cagaggttgt cgttggaaaa ctgtcacctt acagaagcca     2580

attgcaagga ccttgctgct gtgttggttg tcagccggga gctgacacac ctgtgcttgg     2640

ccaagaaccc cattgggaat acaggggtga agtttctgtg tgagggcttg aggtaccccg     2700

agtgtaaact gcagaccttg gtgctttgga actgcgacat aactagcgat ggctgctgcg     2760

atctcacaaa gcttctccaa gaaaaatcaa gcctgttgtg tttggatctg gggctgaatc     2820

acataggagt taagggaatg aagttcctgt gtgaggcttt gaggaaacca ctgtgcaact     2880

tgagatgtct gtggttgtgg ggatgttcca tccctccgtt cagttgtgaa gacctctgct     2940

ctgccctcag ctgcaaccag agcctcgtca ctctggacct gggtcagaat cccttggggt     3000

ctagtggagt gaagatgctg tttgaaacct tgacatgttc cagtggcacc ctccggacac     3060

tcaggttgaa aatcgatgac tttaatgatg aactcaataa gctgctggaa gaaatagaag     3120

aaaaaaaccc acaactgatt attgatactg agaaacatca tccctgggca gaaaggcctt     3180

cttctcatga cttcatgatc tgaatccccc cgagtcattc attctccatg aagtcatcga     3240

ttttccaggt gttggtgaac tgcctgtgac tcctctcctc cccggcccct acccctcagg     3300

gataatgagt tcattgctgg gctagatgtt ttagccatga ttctgcctct gttttatacc     3360

tgcacacatc cttatctttg ttacatatga aatatctgta tcacgggtat attgagagaa     3420

ataaaggtga gagcattc                                                   3438


<210> 4269
<211> 1885
<212> DNA
<213> Homo sapiens

<400> 4269
ggctgcaggt ccgcctgggc cagacgcgcg agcgcaagca gcgggttagt ggtcgcgcgc       60

ccgacctccg cagtcccagc cgagccgcga cccttccggc cgtccccacc ccacctcgcc      120

gccatgcgcc tccgccgcct agcgctgttc ccgggtgtgg cgctgcttct tgccgcggcc      180

cgcctcgccg ctgcctccga gttcttcgcc ccctggtgtg gacactgcaa gagacttgca      240

cctgagtatg aagctgcagc taccagatta aaaggaatag tcccattagc aaaggttgat      300

tgcactgcca acactaacac ctgtaataaa tatggagtca gtggatatcc aaccctgaag      360

atatttagag atggtgaaga agcaggtgct tatgatggac ctaggactgc tgatggaatt      420

gtcagccact tgaagaagca ggcaggacca gcttcagtgc ctctcaggac tgaggaagaa      480

tttaagaaat tcattagtga taaagatgcc tctatagtag gttttttcga tgattcattc      540

agtgaggctc actccgagtt cctaaaagca gccagcaact tgagggataa ctaccgattt      600

gcacatacga atgttgagtc tctggtgaac gagtatgatg ataatggaga gggtatcatc      660

ttatttcgtc cttcacatct cactaacaag tttgaggaca agactgtggc atatacagag      720

caaaaaatga ccagtggcaa aattaaaaag tttatccagg aaaacatttt tggtatctgc      780

cctcacatga cagaagacaa taaagatttg atacagggca aggacttact tattgcttac      840

tatgatgtgg actatgaaaa gaacgctaaa ggttccaact actggagaaa cagggtaatg      900

atggtggcaa agaaattcct ggatgctggg cacaaactca actttgctgt agctagccgc      960

aaaaccttta gccatgaact ttctgatttt ggcttggaga gcactgctgg agagattcct     1020

gttgttgcta tcagaactgc taaaggagag aagtttgtca tgcaggagga gttctcgcgt     1080

gatgggaagg ctctggagag gttcctgcag gattactttg atggcaatct gaagagatac     1140

ctgaagtctg aacctatccc agagagcaat gatgggcctg tgaaggtagt ggtagcagag     1200

aattttgatg aaatagtgaa taatgaaaat aaagatgtgc tgattgaatt ttatgcccct     1260

tggtgtggtc actgtaagaa cctggagccc aagtataaag aacttggcga gaagctcagc     1320

aaagacccaa atatcgtcat agccaagatg gatgccacag ccaatgatgt gccttctcca     1380

tatgaagtca gaggttttcc taccatatac ttctctccag ccaacaagaa gctaaatcca     1440

aagaaatatg aaggtggccg tgaattaagt gattttatta gctatctaca aagagaagct     1500

acaaaccccc ctgtaattca agaagaaaaa cccaagaaga agaagaaggc acaggaggat     1560

ctctaaagca gtagccaaac accactttgt aaaaggactc ttccatcaga gatgggaaaa     1620

ccattgggga ggactaggac ccatatggga attattacct ctcagggccg agaggacaga     1680

atggatataa tctgaatcct gttaaatttt ctctaaactg tttcttagct gcactgttta     1740

tggaaatacc aggaccagtt tatgtttgtg gttttgggaa aaattatttg tgttggggga     1800

aatgttgtgg gggtggggtt gagttggggg tattttctaa ttttttttgt acatttggaa     1860

cagtgacaat aaatgagacc ccttt                                           1885


<210> 4270
<211> 309
<212> DNA
<213> Homo sapiens

<400> 4270
gggagaaacg agatgggggt gaagctggag atatttcgga tgataatcta cctcactttc       60

cctgtggcta tgttctgggt ttccaatcag gccgagtggt ttgaggatga tgtcatacag      120

cgcaagaggg agctgtggcc acctgagaag cttcaagagt tagaggaatt caaagagagg      180

ttacggaagc ggaagcggcg ggaggagaag ctccttcgcg acgcccagca gaactcctga      240

ggcctccaag tgggagtcct agcccctccc ctgatgaaat atacatatac tcagttcctt      300

gttattcaa                                                              309


<210> 4271
<211> 1937
<212> DNA
<213> Homo sapiens

<400> 4271
gcgcgagaat ggcagttgga cggagcctgc ctgccggtgc tccgcccctg ccccgcgctt       60

gactgacgcc aatgagaagc gctcctaagg caattgatgg ttgaaagaac caatcccact      120

cctccagggc gggagcgcac gtagagcagc taggtgggct tcggggttgc agctgctgcg      180

gctccgcagc tgctccggct ccgggaccct tagagtccat tcgcgtgcct tctattgaag      240

agcaggaact gacggttgtt ttaggcctct caattccaga aagtttcctg gggacctgtc      300

cggtcggaaa gtcgagggac agttgtcttg gtatttgtaa agggggtatc cagtgaggcg      360

gagcttgagg gggttgtgtc gagtgactga tacagctgtc aaccaataaa gctactatcg      420

ctcgcctcag gaaaaccatc acaactccag ctggatgtgc gcataatagt gtaatcactc      480

atgattctat tttgtttaat aattcgttct tgagactaga cgtctcgaaa gcgaagactg      540

gcactcctca gcctgccacg gacggctcgc aggccgatac tgaacagaag tacccttatc      600

aaggaggcgt cacccctggg caagcctagc atcagtccat tgacacctac agtcaccatg      660

atagacgttc tcccagacca acagcttcct ttggctcgag gcgggtctta cgtggagggc      720

ctatgggaac tacgtcggct cagccaatag ggtcagggca gggggcgtgg cgggaagttt      780

gaaactggta acttcgggag ttgagccacg agctgttgtg catccagagg tggaattggg      840

gcccggcatt ccctcctcgt cccgggctgg cccttgcccc caccctgcaa ctcctggttg      900

agatgggctc agccaagagc gtcccagtca caccagcgcg gcctccgccg cacaacaagc      960

atctggctcg agtggcggac ccccgttcac ctagtgctgg catcctgcgc actcccatcc     1020

aggtggagag ctctccacag ccaggcctac cagcagggga gcaactggag ggtcttaaac     1080

atgcccagga ctcagatccc cgctctccta ctcttggtat tgcacggaca cctatgaaga     1140

ccagcagtgg agacccccca agcccactgg tgaaacagct gagtgaagta tttgaaactg     1200

aagactctaa atcaaatctt cccccagagc ctgttctgcc cccagaggca cctttatctt     1260

ctgaattgga cttgcctctg ggtacccagt tatctgttga ggaacagatg ccaccttgga     1320

accagactga gttcccctcc aaacaggtgt tttccaagga ggaagcaaga cagcccacag     1380

aaacccctgt ggccagccag agctccgaca agccctcaag ggaccctgag actcccagat     1440

cttcaggttc tatgcgcaat agatggaaac caaacagcag caaggtacta gggagatccc     1500

ccctcaccat cctgcaggat gacaactccc ctggcaccct gacactacga cagggtaagc     1560

ggccttcacc cctaagtgaa aatgttagtg aactaaagga aggagccatt cttggaactg     1620

gacgacttct gaaaactgga ggacgagcat gggagcaagg ccaggaccat gacaaggaaa     1680

atcagcactt tcccttggtg gagagctagg ccctgcatgg ccccagcaat gcagtcaccc     1740

agggcctggt gatatctgtg tcctctcacc ccttctttcc cagggatact gaggaatggc     1800

ttgttttctt agactcctcc tcagctacca aactgggact cacagcttta ttgggctttc     1860

tttgtgtctt gtgtgtttct tttatattaa aggaagtaat tttaaatgtt actttaaaaa     1920

ggtatatgta aaccttg                                                    1937


<210> 4272
<211> 884
<212> DNA
<213> Homo sapiens

<400> 4272
ccatcagcgg ccgggagatc gccttcccca tcgaggcgtg tgtgaccatg ctgcttgagt       60

gtgggatgca ggaggaggga ctcttccgag tagccccctc tgcctccaaa ctgaagaagc      120

tgaaagcggc cctggactgc tgcgtggtgg atgtgcagga gtactcggca gacccccacg      180

caattgcagg agctttgaaa tcttacctcc gagagttgcc agaacctctt atgacctttg      240

aactctatga tgagtggatc caggcttcca atgtccagga gcaagacaag aagcttcagg      300

ctctatggaa tgcttgtgaa aagttgccca aggccaatca caacaacatc cgatacttga      360

taaaatttta tccaagctgt cagaatatca agatgtaaac aagatgactc ccagtaatat      420

ggcaattgtt ttaggaccca acctcctatg gccacaagca gaagggaaca ttacagagat      480

gatgaccaca gtgtcgctgc aaattgttgg gatcattgaa cctatcatcc agcatgcaga      540

ctggttcttc cctggggaga tagagttcaa cattactggc aattatggga gtccagtaca      600

cgtgaaccat aatgccaact acagctcaat gccctcccca gacatggacc ctgctgaccg      660

gcgccagccc gagcaggccc gccggcccct cagcgtcgcc acggataata tgatgctgga      720

gttttacaaa aaggatgggt atgaactggt gtctctttct cagcactggg gattagggga      780

ggtggtgggg gtggatgggt gacgcataag aaaaatacaa ttacgggaag gctgcactga      840

ctctcagcag tttaggtgac tcgtagcaat taaactgtat ctgc                       884


<210> 4273
<211> 1220
<212> DNA
<213> Homo sapiens

<400> 4273
atgcacacat acgcgcgcgc acatgcacat aggcacacag agatacgcgc acacacacac       60

acaaacgcac tcagatttcc cggaccctgg ttttcctcct gtgacccttt cggggccggg      120

ctctcaccct aaagaagcag ccccgccctg gggtggcccc accctctctt gggacctgtc      180

ataagtcgga ccccgggcgc ccggctgcgc agtcccagcc gccttcccca ggcagtggaa      240

ccttcgggct cctgagcttc aggatggttc gtactaagac atggaccctg aagaagcact      300

ttgttggcta tcctactaat agtgactttg agttgaagac agctgagctc ccacccttaa      360

aaaatggaga ggtcctgctt gaagctttgt tcctcaccgt ggatccctac atgagagtgg      420

cagccaaaag attgaaggaa ggtgatacaa tgatggggca gcaagtggcc aaagttgtgg      480

aaagtaaaaa tgtagcccta ccaaaaggaa ctattgtact ggcttctcca ggctggacaa      540

cgcactccat ttctgatggg aaagatctgg aaaagctgct gacagagtgg ccagacacaa      600

taccactgtc tttggctctg gggacagttg gcatgccagg cctgactgcc tactttggcc      660

tacttgaaat ctgtggtgtg aagggtggag aaacagtgat ggttaatgca gcagctggag      720

ctgtgggctc agtcgtgggg cagattgcaa agctcaaggg ctgcaaagtt gttggagcag      780

tagggtctga tgaaaaggtt gcctaccttc aaaagcttgg atttgatgtc gtctttaact      840

acaagacggt agagtctttg gaagaaacct tgaagaaagc gtctcctgat ggttatgatt      900

gttattttga taatgtaggt ggagagtttt caaacactgt tatcggccag atgaagaaat      960

ttggaaggat tgccatatgt ggagccatct ctacatataa cagaaccggc ccacttcccc     1020

caggcccacc cccagagatt gttatctatc aggagcttcg catggaagct tttgtcgtct     1080

accgctggca aggagatgcc cgccaaaaag ctctgaagga cttgctgaaa tgggtcttag     1140

agatcaaaag agaaaatgaa gaagattgaa gcttcaaagc agaaaaatga agggaatatg     1200

tatcattcac cattacctta                                                 1220


<210> 4274
<211> 1317
<212> DNA
<213> Homo sapiens

<400> 4274
ggatggtgaa ccctgaagtc ggtgtctgct gcgttcacgg caggattcgg ttaggaggaa       60

cagcacagca tgctgggctc tggatttaaa gctgagcgct taagagtgaa tttgagatta      120

gtcataaatc gccttaaact attggagaaa aagaaaacgg aactggccca gaaagcaagg      180

aaggagattg ctgactatct ggctgctggg aaagatgaac gagctcggat ccgtgtggag      240

cacattatcc gggaagacta cctcgtggag gccatggaga tcctggagct gtactgtgac      300

ctgctgctgg ctcggtttgg ccttatccag tctatgaagg aactagattc tggtctggct      360

gaatctgtgt ctacattggc tgagttgaaa atagttgctg atcagctctg tgccaagtat      420

agcaaggaat atggcaagct atgtaggacc aaccagattg gaactgtgaa tgacaggcta      480

atgcacaagc tgagtgtgga agccccaccc aaaatcctgg tggagagata cctgattgaa      540

attgcaaaga attacaacgt accctatgaa cctgactctg tggtcatggc agaagctcct      600

cctggggtag agacagatct tattgatgtt ggattcacag atgatgtgaa gaaaggaggc      660

cctggaagag gagggagtgg tggcttcaca gcaccagttg gtggacctga tggaacggtg      720

ccaatgccca tgcccatgcc catgcctatg ccatctgcaa atacgccttt ctcatatcca      780

ctgccaaagg gaccatcaga tttcaatgga ctgccaatgg ggacttatca ggcctttccc      840

aatattcatc cacctcagat accagcaact cccccatcgt atgaatctgt agatgacatt      900

aatgctgata agaatatctc ttctgcacag attgttggtc ctggacccaa gccagaagcc      960

tctgcaaagc ttccttccag acctgcagat aactatgaca actttgtcct accagagttg     1020

ccatctgtgc cagacacact accaactgca tctgctggtg ccagcacctc agcatctgaa     1080

gacattgact ttgatgatct ttcccggagg tttgaagagc tgaaaaagaa aacataggtc     1140

tcttaaacca ggcaactttc acgttttggg agttgagact gagcaatttc tccttgtaac     1200

aaagaatctc catgaaattc tgtttcatct gttaaccgtc actcagcaca acactccctc     1260

tgggctctct tcctgctcct ccagattctg ctgctttcca gttctctgtt gatcctg        1317


<210> 4275
<211> 2255
<212> DNA
<213> Homo sapiens

<400> 4275
cttggttcta gcacatgcag atgacaatcc aggctctcca ggatgaattg cggatccaga       60

gggacctgaa tcagctgttt cagcaggata gtagcagcag gactggcgaa ccttgtgtag      120

cagagctgac agaggagaac tttcagaggc ttcatgctga gcatgagcgg caggccaaag      180

agctgtttct tcttcgaaag acattggagg aaatggagct gcgtattgag actcaaaagc      240

agaccctaaa tgctcgggat gaatccatta agaagcttct ggaaatgttg cagagcaaag      300

gactttctgc caaggctacc gaggaagacc atgagagaac aagacgactg gcagaggcag      360

agatgcacgt tcatcaccta gaaagccttt tggagcagaa ggaaaaagag aacagtatgt      420

tgagagagga gatgcatcga aggtttgaga atgctcctga ttctgccaaa acaaaagctc      480

tgcaaactgt tattgagatg aaggattcaa aaatttcctc tatggagcgt gggcttcgag      540

acctggaaga ggaaattcag atgctgaaat cgaatggtgc tttgagtact gaggaaaggg      600

aagaagaaat gaagcaaatg gaagtgtatc ggagccattc taaatttatg aaaaataaga      660

ttggccaggt gaaacaggag ctgtccagaa aggacacaga actactcgcc ctgcagacaa      720

agctagaaac actcacaaac cagttctcag atagtaaaca gcacattgaa gtgttgaagg      780

agtccttgac tgctaaggag cagagggctg ccatcctgca gactgaggtg gatgctctcc      840

gattgcgttt ggaagagaag gaaaccatgt tgaataaaaa gacaaaacaa attcaggata      900

tggctgaaga gaaggggaca caagctggag agatacatga cctcaaggac atgttggatg      960

tgaaggagcg gaaggttaat gttcttcaga agaagattga aaatcttcaa gagcagctta     1020

gagacaagga aaagcagatg agcagcttga aagaacgggt caaatccttg caggctgaca     1080

ccaccaacac tgacactgcc ttgacaactt tggaggaggc ccttgcagag aaagagcgga     1140

caattgaacg cttaaaggag cagagggaca gagatgagcg agagaagcaa gaggaaattg     1200

ataactacaa aaaagatctt aaagacttga aggaaaaagt cagcctgttg caaggcgacc     1260

tttcagagaa agaggcttca cttttggatc tgaaagagca tgcttcttct ctggcatcct     1320

caggactgaa aaaggactca cggcttaaga cactagagat tgctttggag cagaagaagg     1380

aggagtgtct gaaaatggaa tcacaattga aaaaggcaca tgaggcagca ttggaagcca     1440

gagccagtcc agagatgagt gaccgaatac agcacttgga gagagagatc accaggtaca     1500

aagatgaatc tagcaaggcc caggcagaag ttgatcgact cttagaaatc ttgaaggagg     1560

tggaaaatga gaagaatgac aaagataaga agatagctga gttggaaagt ctcacctcaa     1620

ggcaagtgaa agaccagaat aagaaggtag caaatctgaa gcacaaggaa caggtggaaa     1680

aaaagaagag tgcacaaatg ttagaggagg cgcgacgacg ggaggacaat ctcaacgaca     1740

gctctcagca gctacaggtg gaggagttac tgatggccat ggagaaggta aagcaggaac     1800

tagaatccat gaaagcaaag ctgtcctcca cccagcagtc tctggcagaa aaggaaactc     1860

acttgactaa tcttcgggca gagagaagga aacacttaga ggaagttctg gagatgaagc     1920

aagaagctct tctggctgcc attagtgaaa aagacgccaa tatagctctc ttggagcttt     1980

cgtcctctaa gaagaagacc caagaggaag tggctgccct gaagcgggag aaggatcgtc     2040

tggtacagca gcttaagcag cagacgcaaa atcgaatgaa gctaatggcc gacaactacg     2100

aggatgacca cttcaaatcc tcccattcca atcaaacaaa tcacaagccc tccccagacc     2160

aggatgagga ggagggtata tgggcatagc caatcagagg cttagttcag ccattttgtt     2220

cagaacgatc atccagcccc tcttagaact tgacc                                2255


<210> 4276
<211> 1231
<212> DNA
<213> Homo sapiens

<400> 4276
gaagttgctg gctgactggg cttgcgagga aaccgcctcg gagctgcagc cgaaggccaa       60

ggaatcactg aagatcggcg agggaggaca gggggttcat catggccatt ggatttaatg      120

tagagacggt gacgtacaaa aaccttaaat tccaagtctg ggatttagga ggacagacaa      180

gtatcaggcc atactggaga tgttactatt caaacacaga tgcagtcatt tatgtagtag      240

acagttgtga ccgagaccga attggcattt ccaaatcaga gttagttgcc atgttggagg      300

aagaagagct gagaaaagcc attttagtgg tgtttgcaaa taaacaggac atggaacagg      360

ccatgacttc ctcagagatg gcaaattcac ttgggttacc tgccttgaag gaccgaaaat      420

ggcagatatt caaaacgtca gcaaccaaag gcaccggcct tgatgaggca atggaatggt      480

tagttgaaac attaaaaagc agacagtaat tcagtccatt cttctcccct gaaatgaaga      540

ctacatcacc tctctccctt tggaaacagt caagtgtact tcacactact agatgttaaa      600

actatatgat tattggcata tactgactga ctgcaatatt tgtagtaaat agggaaaata      660

agtatttagt tggagggata atttgatcga atcacctgaa tgttctatgt aatgtaaaat      720

attcttttct tgctttcttg tgttaaggta tatattctat ttgtatggaa ttcttattca      780

aatacagttc tattaaagag tatactccta ttggatgaaa aaaacctatt tttgaatagt      840

agttgcagct tgtttgtata aatactaaaa aatatcttaa cagatttttt tccccttaaa      900

atgaattatc tttccaaaga ttagactcag tatgagagta ggtgaggaac atagtttgtg      960

taatataatc tttatttgct tacctgacca ctttttatta agctgttttg tttaaaagct     1020

tttggttata ggcatgaata ttgttttgat ggttaacttc actgacttat ctgtaagtgt     1080

cattttatag tactttacag ttgtcaaaaa aaatcttaca tatattgatc tagttgatcg     1140

gtagaggaag cttgtgaagt aggtaggaca ggttatgatg tcttcactgt atggacgtga     1200

acccagggtt ctaataggtt ggcttgccca a                                    1231


<210> 4277
<211> 683
<212> DNA
<213> Homo sapiens

<400> 4277
aggaggcaga tcctgaaaga gcttgccctg tgtctgcgga ggcaagagat gtatgggcct       60

agagcagcta gcagaaacaa ggagaccagt gctggtccag tggctgtgat gggaaaagat      120

tattacaaga ttcttgggat cccatcgggg gccaacgagg atgagatcaa gaaagcctac      180

cggaagatgg ccttgaagta ccacccagac aagaataaag aacccaacgc tgaggagaag      240

tttaaggaga ttgcagaggc ctatgatgtg ctaagtgacc ccaagaaacg gggcctgtat      300

gaccagtatg gggaggaagg cctgaagacc ggcggtggca catcaggtgg ctccagtggc      360

tcctttcact acacctttca tggggacccc catgccacct ttgcctcctt ctttggtggc      420

tccaacccct tcgatatctt ctttgccagc agccgctcca ctcggccctt cagtggcttt      480

gacccagatg acatggatgt ggatgaagat gaggacccat ttggcgcttt cggccgtttt      540

ggcttcaatg ggctgagtag gggtccaagg cgagccccag aaccactgta ccctcggcgc      600

aaggtgcagg accccccagt ggtgcacgag ctgcgggtgt ccctggagga gatctaccat      660

ggctccacca agcgcatgaa gat                                              683


<210> 4278
<211> 560
<212> DNA
<213> Homo sapiens

<400> 4278
gagccgacga gccgggaggc gggaggcggc ggccgcggcg gctgctgctg ctgcagtggg       60

acaggtggcg gcgaccggcg gcgtccgagg agtctcttct gtatatacag aaatatgaat      120

gtgaatgaag tggaaggaag aaaatcaaat agcttgccct ttcttaaggg gaaacaagtc      180

aatttggaaa ggtcccagcg ttgtatttaa tccagagact gacttcacta tagaacccac      240

agttgtatca atggttgggg aaagatagtg gcaacaggca aaggagaaac agctctgaca      300

tacaaagaaa atgagtatgc taaagccaag tgggcttaag gcccccacca agatcctgaa      360

gcctggaagc acagctctga agacacctac ggctgttgta gctccagtag aaaaaaccat      420

atccagtgaa aaagcatcaa gcactccatc atctgagact caggaggaat ttgtggatga      480

ctttcgagtt ggggagcgag tttgggtgaa tggaaataag cctggattta tccagtttct      540

tggagaaacc cagtttgcac                                                  560


<210> 4279
<211> 1245
<212> DNA
<213> Homo sapiens

<400> 4279
ctctgctcgc cgccgccgct gtcgccgcca cctcctctga tctacgaaag tcatgttacc       60

caacaccggg aggctggcag gatgtacagt ttttatcaca ggtgcaagcc gtggcattgg      120

caaagctatt gcattgaaag cagcaaagga tggagcaaat attgttattg ctgcaaagac      180

cgcccagcca catccaaaac ttctaggcac aatctatact gctgctgaag aaattgaagc      240

agttggagga aaggccttgc catgtattgt tgatgtgaga gatgaacagc agatcagtgc      300

tgcagtggag aaagccatca agaaatttgg aggaattgat attctggtaa ataatgccag      360

tgccattagt ttgaccaata cattggacac acctaccaag agattggatc tgatgatgaa      420

cgtgaacacc agaggcacct accttgccca tacacactgc tgctatggat atgctgggag      480

gacctggtat cgaaagccag tgtagaaaag ttgatatcat tgcagatgca gcatattcca      540

ttttccaaaa gccaaaaagt tttactggca actttgtcat tgatgaaaat atcttaaaag      600

aagaaggaat agaaaatttt gacgtttatg caattaaacc aggtcatcct ttgcaaccag      660

atttcttctt agatgaatac ccagaagcag ttagcaagaa agtggaatca actggtgctg      720

ttccagaatt caaagaagag aaactgcagc tgcaaccaaa accacgttct ggagctgtgg      780

aagaaacatt tagaattgtt aaggactctc tcagtgatga tgttgttaaa gccactcaag      840

caatctatct gtttgaactc tccggtgaag atggtggcac gtggtttctt gatctgaaaa      900

gcaagggtgg gaatgtcgga tatggagagc cttctgatca ggcagatgtg gtgatgagta      960

tgactactga tgactttgta aaaatgtttt cagggaaact aaaaccaaca atggcattca     1020

tgtcagggaa attgaagatt aaaggtaaca tggccctagc aatcaaattg gagaagctaa     1080

tgaatcagat gaatgccaga ctgtgaagga aaatataaaa aaaaagtcga ctgctatgct     1140

caaaaagtaa aaaaagctca acagttaaaa tctaatgttt gttttctttc ctgttatatt     1200

ataaggatat gcacgtttgt tctggaaaag atagaatttg tctct                     1245


<210> 4280
<211> 1407
<212> DNA
<213> Homo sapiens

<400> 4280
agagcaagga agggcagggg acctgggaag gaagttctgg aaggcagtgg ggtttgagat       60

tggacccagg gtcaagatag aacatgaagg tgggatgagg acatgaacag aacatggcca      120

agaaggatct gggggagcag ccaggacgag ccggagttcg cgagcagtgt gcggcggccg      180

catctgacat cggatgccgt ggcgctgctg cgggacaacg tcactccacg tgaaaacgag      240

ctctggacct cgctggggga ctcgtggacc cgccccgggc tggagctgtc cccggaggag      300

ggacccccat acagacccga gttcttcagc ggctgggagc cgccggtcac tgacccgcag      360

agccgcgcct gggaggaccc agttgagaaa cagctacagc acgagcggag gcgccggcag      420

gtgacccaag cgacacagca gggccgaggc tgggaagtcc gggggcgcgg ccggtccgcc      480

tggccccgcc tgacccgact gtcttacttc ctacagcaaa gcgcccccca ggtcgctgtc      540

aatggtcacc gagacttgga gccagaatct gagcctcagc tggagtcaga gacagcagga      600

aaatgggtcc tgtgtaatta tgacttccag gcccgcaaca gcagtgagct gtcggtcaag      660

cagcgggacg tactggaggt cctggatgac agtcgtaagt ggtggaaggt tcgggaccca      720

gcggggcagg agggatatgt gccctacaac atcctgacac cctaccccgg accccggctg      780

caccacagcc aaagccctgc ccgcagcctg aacagcactc ctcctccacc accagcccca      840

gccccggccc cacctccagc tctggctcgg ccccgctggg acaggccccg ctgggacagc      900

tgcgatagcc tcaacggctt ggaccccagc gagaaggaga aattctccca gatgctcatc      960

gtcaacgagg aactgcaggc gcgcctggcc cagggccgct cgggaccgag ccgcgcagtc     1020

ccagggcccc gcgccccgga accgcagctc agcccgggct cggacgcctc cgaggtccgc     1080

gcctggctgc aggccaaggg ctttagctcc gggaccgtgg acgcgctggg tgtgctgacc     1140

ggggcgcagc ttttctcgct gcagaaggag gagctgcggg cggtgagccc cgaggagggg     1200

gcacgtgtgt acagccaggt caccgtgcag cgctcgctgc tggaggacaa agagaaagtg     1260

tcagagctgg aggcagtgat ggagaagcaa aagaagaagg tggaaggcga ggtggaaatg     1320

gaggtcattt gacctgccag gcgcccttcg caaagagtga cgaggccccg tgggagaacg     1380

gactcctcag actctcccca atagcgg                                         1407


<210> 4281
<211> 1718
<212> DNA
<213> Homo sapiens

<400> 4281
agttgcaact tgtctttgag tgcagggaca ggagaagtgt gggctacccg gccactgccc       60

tggagctgtg gtgactgctg cgtttttctc ccatgcactt gcacgtccag gactcctggg      120

agaacttggg ccacactcct tccttgccct cttgagctca ttcgtcaccc tgttgggtga      180

gcacagccct agctcaggcc actgggcaag ccacaccatc caaagaggag gtcctctgcc      240

ccaggacccc cacaccaccc cagctccctg tttcgctgag gcctggagcc cccatggcct      300

cactgagccg agccctacgt gtggctgctg cccaccctcg ccagagccct acccggggca      360

tggggccatg caacctgtcc agcgcagctg gccccacagc cgagaagagt gtgccatatc      420

agcggaccct gaaggaggga cagggcacct cggtggtggc ccaaggccca agccggcccc      480

tgcccagcac ggccaacgtg gtggtcattg gtggaggcag cttgggctgc cagaccctgt      540

accacctggc caagctgggc atgagtgggg cggtgctgct ggagcgggag cggctgacct      600

ccgggaccac ctggcacacg gcaggcctgc tgtggcagct gcggcccagt gacgtggagg      660

tggagcttct ggcccacact cggcgggtgg tgagccggga gctggaggag gagacgggac      720

tacacacggg ctggatccag aatgggggcc tcttcatcgc gtccaaccgg cagcgcctgg      780

acgagtacaa gaggctcatg tcgctgggca aggcgtatgg tgtggaatcc catgtgctga      840

gcccggcaga gaccaagact ctgtacccgc tgatgaatgt ggacgacctc tacgggaccc      900

tgtatgtgcc gcacgacggt accatggacc ccgctggcac ctgtaccacc ctcgccaggg      960

cagcttctgc ccgaggagca caggtcattg agaactgccc agtgaccggc attcgtgtgt     1020

ggacggatga ttttggggtg cggcgggtcg cgggtgtgga gactcagcat ggttccatcc     1080

agacaccctg cgtggtcaac tgtgcaggag tgtgggcaag tgctgtgggc cggatggctg     1140

gagtcaaggt cccgctggtg gccatgcacc atgcctatgt cgtcaccgag cgcatcgagg     1200

ggattcagaa catgcccaat gtccgtgatc atgatgcctc tgtctacctc cgcctccaag     1260

gggatgcctt gtctgtgggt ggctatgagg ccaaccccat cttttgggag gaggtgtcag     1320

acaagtttgc cttcggcctc tttgacctgg actgggaggt gttcacccag cacattgaag     1380

gcgccatcaa cagggtcccc gtgctggaga agacaggaat caagtccacg gtctgcggcc     1440

ctgaatcctt cacgcccgac cacaagcccc tgatggggga ggcacctgag ctccgagggt     1500

tcttcctggg ctgtggcttc aacagcgcag gaatgatgct gggtggtggc tgtgggcagg     1560

agctggccca ctggatcatc catgggcgcc cggagaagga catgcatggc tatgacatca     1620

ggcgcttcca tcactcgctc acggaccacc cccgctggat ccgagagcga agccatgagt     1680

cctaccaaga actactccgt cgtcttcccc cacgatga                             1718


<210> 4282
<211> 2525
<212> DNA
<213> Homo sapiens

<400> 4282
cccctcgttt ctccctcccc gcctcctccg cagaagccaa gtgctgttcc accaactagt       60

cccgttgcag gtgaaatgca aagactgtga ggagaggaga gtaagtataa gaatgagcat      120

tgaactacaa tcagtttcta atccagttca cagaaaggac ttagttattc gtctgactga      180

tgacacggat ccattttttt tatataacct tgttatatct gaggaagatt ttcaaagttt      240

aaaattccag caaggtcttc tggtagactt cttagctttc ccacaaaaat ttatagatct      300

ccttcagcaa tgtactcaag aacatgccaa agaaattcca aggtttttgc tacagttagt      360

ttctccagca gctattttgg ataactcacc tgcattttta aatgtggtag agacaaatcc      420

ttttaagcat cttacacacc tctcactaaa acttttacct ggaaatgatg tggagataaa      480

gaaatttctc gcaggctgtt tgaaatgtag caaggaagaa aaattatcat tgatgcaatc      540

actagatgat gctactaagc aactggactt tacacgaaag acattagcag aaaaaaaaca      600

agaattagat aagttacgga atgaatgggc gtcacataca gcagccttga caaacaagca      660

ttctcaggaa ctgacaaatg aaaaggaaaa agccttgcag gcacaggttc aatatcaaca      720

gcagcatgaa caacagaaaa aagatttaga aatcctccat caacaaaaca tccaccagct      780

acaaaacaga ctgtctgagt tagaagcggc taataaagac ttaaccgaaa gaaaatataa      840

aggagactcc actattagag aacttaaagc aaaactttct ggtgttgaag aggagctaca      900

gcggactaag caagaagtcc tctctttgcg aagagagaat tctacactag atgttgaatg      960

ccacgagaaa gaaaagcacg ttaatcagct acaaacaaaa gtggcagttt tagaacagga     1020

aatcaaggat aaggaccagc ttgttttaag aacaaaagag gcatttgata caatccagga     1080

acaaaaggtg gttttagaag aaaatggtga gaaaaatcaa gtacaactag gaaagcttga     1140

agctacaata aaatcattat ctgcagaact tctgaaggca aatgaaatta tcaagaagtt     1200

acaaggggat ctgaaaactt taatgggtaa gttgaaattg aagaatacag ttactattca     1260

gcaagaaaaa ctcttggctg agaaggagga aaaattacaa aaggaacaaa aggaattaca     1320

agatgttgga cagtctcttc gaattaaaga gcaagaggta tgcaaattac aagaacaatt     1380

agaagctaca gttaaaaaac ttgaagaaag caaacaactt ctaaaaaata atgaaaagtt     1440

aatcacgtgg ttaaataaag aactaaatga aaatcagcta gtgagaaagc aagatgtatt     1500

gggaccttct actactccgc ctgcacattc cagcagcaac acaatcagaa gtggaatttc     1560

tcctaacctg aatgtggttg atggtagact gacttaccca acctgtggga ttggttatcc     1620

tgtctcctct gcatttgcat tccagaatac cttccctcat tcgatatctg ccaaaaatac     1680

cagccaccct ggttcaggaa caaaggttca gtttaatttg cagtttacaa aaccaaatgc     1740

atcactagga gatgttcagt caggagcaac tattagtatg ccttgctcaa ctgataagga     1800

aaatggtgaa aatgtagggt tggaatccaa atacctgaag aaaagggaag atagcattcc     1860

tttacgcgga ctcagccaga acctatttag taattcagac catcagagag atggcacttt     1920

aggagcatta catacatctt ccaaacccac agcgctcccc tctgcgtctt cagcctattt     1980

ccctgggcag ttaccaaaca gttaattcta gtgtcatgtt ttacttttta ttggtatttt     2040

agaaactcag gtgcttaaaa aatatgtcaa cacaaaccag atcctcaaat agcaagtttc     2100

aaattttact tgagctgtta aagactggat actttaagta ctgcttttat ggcagtttat     2160

aatataggaa caaatttgta cttggggatt ggtaaagatt gtgagtaaat gacatttttt     2220

ggtttgtgaa catggcgttt tatagaataa tatgaatttt attaagctat tctttagaaa     2280

ttcagttcta aggaaagagt tgatccttat gagggagatt ctgatcatat taaaaatctg     2340

ggtaaactaa aacctgctca taacctcata gtatgcaacc aaagaatact aattcatttt     2400

atcactttca ttggtaaaac ttttaaattc aacacctgaa aatcatgagg gaaaatgatt     2460

acctcttgag atatattatt gatgacattt aaagggaaaa gtcctaaatt taccttaaat     2520

aactg                                                                 2525


<210> 4283
<211> 1590
<212> DNA
<213> Homo sapiens

<400> 4283
actcagcatc gtttcctttt cctccgctgg agcagctatg gcggcggtga agaccctgaa       60

ccccaacagc ttccttaata gcaaaggtag caacagccca ggatgatata actggtgatg      120

gtacgacttc taatgtccta atcattggag agctgctgaa acaggcggat ctctacattt      180

ctgaaggcct tcatcctaga ataatcactg aaggatttga agctgcaaag gaaaaggccc      240

ttcagttttt ggaagaagtc aaagtaagca gagagatgga cagggaaaca cttatagatg      300

tggccagaac atctcttcgt actaaagttc atgctgaact tgcagatgtc ttaacagagg      360

ctgtagtgga ctccattttg gccattaaaa agcaagatga acctattgat ctcttcatga      420

ttgagatcat ggagatgaaa cataaatctg aaactgatac aagcttaatc agagggcttg      480

ttttggacca cggagcacgg catcctgata tgaagaaaag ggtggaggat gcatacatcc      540

tcacttgtaa cgtgtcatta gagtatgaga aaacagaagt gaattctggc tttttttaca      600

agagtgcaga agagagagaa aaactcgtga aagctgaaag aaaattcatt gaagataggg      660

ttaaaaaaat aatagaactg aaaaggaaag tctgtggcga ttcagataaa ggatttgttg      720

ttattaatca aaagggaatt gacccctttt ccttagatgc tctttcaaaa gaaggcatag      780

ttgctctgcg cagagctaaa aggagaaata tggagaggct gactcttgct tgtggtgggg      840

tagccctgaa ttcttttgac gacctaagtc ctgactgctt gggacatgca ggacttgtat      900

atgagtatac attgggagaa gagaagttta cctttattga gaaatgtaac aaccctcgtt      960

ctgtcacatt attgatcaaa ggaccaaata agcacacact cactcagatc aaagatgcag     1020

tgagggacgg cttgagggct gtcaaaaatg ctattgatga tggctgtgtg gttccaggtg     1080

ctggtgccgt ggaagtggca atggcagaag ccctgattaa acataagccc agtgtaaagg     1140

gcagggcaca gcttggagtc caagcatttg ctgatgcatt gctcattatt cccaaggttc     1200

ttgctcagaa ctctggtttt gaccttcagg aaacattagt taaaattcaa gcagaacatt     1260

cagaatcagg tcagcttgtg ggtgtggacc tgaacacagg tgagccaatg gtggcagcag     1320

aagtaggcgt atgggataac tattgtgtaa agaaacagct tcttcactcc tgcactgtga     1380

ttgccaccaa cattctcttg gttgatgaga tcatgcgagc tggaatgtct tctctgaaag     1440

gttgaattga agcttcctct gtatctgaat cttgaagact gcaaagtgat cctgaggatt     1500

acagctgtgg aatttttgtc caagcttcaa ataattttga aagaaatttt cccatatgaa     1560

aaaaggagag aacactggca tctgttgaaa                                      1590


<210> 4284
<211> 1041
<212> DNA
<213> Homo sapiens

<400> 4284
tctcgtcgca gccgccgcgg ctggcgggcc ttgggcttcc cctgaagcat gagccctctc       60

gcccgcagcc accctcaccg cgtggcccgc ggacagtgcg cgccggggtc ccgggtgcac      120

agcctcagga taccccgtgc ccgcagctcg ggcgcccgcg gcaggcgatc agtgggtgac      180

cgcggctgcg agggactttg tcatccgtcc tccaggatct ggggagaaag agccccatcc      240

cttctctctc tgccaccatt tcggacaccc cgcaggcggc gcgtctggcg aaggccctgc      300

gggagctcgg tcagacagga tggtactggg gaagtatgac tgttaatgaa gccaaagaga      360

aattaaaaga ggcaccagaa ggaactttct tgattagaga tagctcgcat tcagactacc      420

tactaacaat atctgttaaa acatcagctg gaccaactaa tcttcgaatc gaataccaag      480

acggaaaatt cagattggac tctatcatat gtgtcaaatc caagcttaaa caatttgaca      540

gtgtggttca tctgatcgac tactatgttc agatgtgcaa ggataagcgg acaggtccag      600

aagccccccg gaacggcact gttcaccttt atctgaccaa accgctctac acgtcagcac      660

catctctgca gcatctctgt aggctcacca ttaacaaatg taccggtgcc atctggggac      720

tgcctttacc aacaagacta aaagattact tggaagaata taaattccag gtataaatgt      780

ttctcttttt ttaaacatgt ctcacataga gtatctccga atgcagctat gtaaaagaga      840

accaaaactt gagtgctctg gataactata tggaatgctt tctaagaaca gctgaagcta      900

atctaattta aatttaacag cttgaagagg tagctaggtg tttaaagttc ctccagatac      960

ttttacctga gtgatgcttc ccttcctaag gctgaccaag acctgttgat ccttttagat     1020

taaaaataaa atgtcgcatg t                                               1041


<210> 4285
<211> 2608
<212> DNA
<213> Homo sapiens

<400> 4285
accttagcaa ccttctcctg gtgcagagtc ctaagaggtt tggggctcca taaccacaaa       60

ggtggaagcg aggggaaggc tgctccccac cacctcgccc ccaccgctgg ggaagggtta      120

ccatgacaac caacctggcc ggcaatcaga gaggatgggg ccactgctgg tcgccctttc      180

tctcagagta aaagtaattg tccaggagag tggtgtttgg gtgtggaagg gcacgagtgg      240

gcgcgcttcg aagccgagaa agcccgctgg gaggccgagc gcgccgagtt acaggctcag      300

gtggccttcc ttcagggaga gaggaaaggg caggagaatc taaagacgga cctggtgcgg      360

cggatcaaga tgctagagta tgcgctgaag caggaaaggg ccaaatatca taaactgaag      420

tttgggacag acctgaacca gggggagaag aaagcagatg tgtcagaaca agtctccaat      480

ggccccgtgg aatcggtcac cctggagaac agcccgttgg tgtggaagga ggggcggcag      540

cttctccgac agtacctgga agaggtgggc tacacagaca ccatcctcga catgcggtcc      600

aagcgcgtcc gttccctgct gggccgctcg ctggagctca acggggcagt ggagccgagt      660

gaaggggccc ccagggctcc accaggccct gcagggctca gtggtgggga gtcgctgctg      720

gtgaaacaga tcgaggagca gataaagagg aacgcggcag gcaaagatgg caaagagcgc      780

ttgggcggct cagtgctggg gcagatcccc ttcctgcaga actgcgagga cgaagacagc      840

gacgaggacg atgagctgga cagcgtgcag cacaagaagc agcgtgtgaa gctcccatcc      900

aaggctctgg tgcccgaaat ggaagacgag gatgaggaag acgactctga ggatgctatc      960

aatgagtttg atttcctggg ctcaggagag gatggggaag gggctccaga ccctcggcgg     1020

tgcactgtgg atgggagccc ccatgagctg gaaagccgtc gggtcaaact ccaaggcatt     1080

ctggctgacc tgcgggatgt ggatgggctg cccccaaaag tgactggccc gcctcctggc     1140

acaccccagc cccggccaca tgaagacgtc ttcatcatgg acactatcgg gggcggggag     1200

gtgagcctgg gggacttggc agatctcacc gtcaccaacg acaacgacct cagctgcgat     1260

ctgtctgaca gcaaagatgc ttttaagaag acgtggaacc ccaagttcac cctgcgctcg     1320

cactacgacg gcattcgttc cctggccttc caccacagcc agtcggctct gctcaccgcc     1380

tccgaggacg gcacgctcaa gctctggaac ctgcagaagg cggtcacggc caagaagaat     1440

gcggcgctag atgtggaacc tatacatgct ttccgggctc acaggggccc agtgttggct     1500

gtggctatgg gcagcaacag tgaatactgc tacagtggcg gggcagatgc ctgcatccat     1560

agttggaaga ttccagacct cagcatggat ccctatgatg gctacgaccc aagcgtgctg     1620

agccacgtcc tggagggcca cggggacgcc gtgtggggcc tggccttcag tcccacctcc     1680

cagcgcctgg cctcctgttc tgctgatggc accgtccgca tctgggaccc cagcagcagc     1740

agcccggcct gcctctgcac cttccccaca gccagcgagc acggggtccc cacctcagtg     1800

gccttcacca gcaccgagcc tgcccacatc gtggcctcct tccgctctgg cgacaccgtc     1860

ttgtatgaca tggaggttgg cagtgccctc ctcacgctgg agtcccgggg cagcagcggt     1920

ccaacccaga tcaaccaagt ggtgagtcat ccaaaccagc ctctcaccat caccgcccac     1980

gacgacaggg gcatccgctt cctggacaat cggacaggta agccggtgca ctccatggtt     2040

gcacacctgg acgcagtcac ctgcctagcc gtggacccca acggcgcatt cctgatgtca     2100

ggaagccatg actgctccct gcgtctctgg agcctggaca acaaaacgtg cgtgcaggag     2160

atcacggccc accgcaagaa gcacgaggag gccatccacg ctgttgcctg ccaccccagc     2220

aaggccctca ttgccagtgc tggcgctgat gccctggcca aggtcttcgt atgatgccca     2280

cctggccctg ccctggccgc cacgctggct ggggtgtagg gccgggcagg tggggctgag     2340

gggactccca gcctcgctgg aggtgcagag gcctggcctc tgtctgtttg ccatggagcc     2400

tggtggtgct aacggccctt tccccaggaa tccctcccca acggctgcct tccccaagca     2460

tccagcctgg ggatgggccc ctttcaggaa tcacccccga ggatggcctc ggggtttccc     2520

cctgtgccct gacagccgct cctggtatca gagctgcttt ccagagggca gcacagccag     2580

ggccgggtgt ctttagggat cagttttt                                        2608


<210> 4286
<211> 2312
<212> DNA
<213> Homo sapiens

<400> 4286
agagaggcag ccttcagacc tatgttccca gaaatctcta cgtttgtgcc tttcccaact       60

agagaattaa ctcttgcggg gcacaaaaca gcctctattt ctttgcgtcc ccagcgcctg      120

tttgttgaag actgagttga aggagtagca ggtggtgtta atttgtcaaa aagatgagtt      180

aaggtgctgg gggcgagggg gaacaccccc acggccctcc ccccacagca aggcagattt      240

tgtggaagta taatactttg tcattatgag atgtcgtctc tcggtgcctc ctttgtgcaa      300

attaaatttg atgacttgca gttttttgaa aactgcggtg gaggaagttt tgggagtgtt      360

tatcgagcca aatggatatc acaggacaag gaggtggctg taaagaagct cctcaaaata      420

gagaaagagg cagaaatact cagtgtcctc agtcacagaa acatcatcca gttttatgga      480

gtaattcttg aacctcccaa ctatggcatt gtcacagaat atgcttctct gggatcactc      540

tatgattaca ttaacagtaa cagaagtgag gagatggata tggatcacat tatgacctgg      600

gccactgatg tagccaaagg aatgcattat ttacatatgg aggctcctgt caaggtgatt      660

cacagagacc tcaagtcaag aaacgttgtt atagctgctg atggagtatt gaagatctgt      720

gactttggtg cctctcggtt ccataaccat acaacacaca tgtccttggt tggaactttc      780

ccatggatgg ctccagaagt tatccagagt ctccctgtgt cagaaacttg tgacacatat      840

tcctatggtg tggttctctg ggagatgcta acaagggagg tcccctttaa aggtttggaa      900

ggattacaag tagcttggct tgtagtggaa aaaaacgaga gattaaccat tccaagcagt      960

tgccccagaa gttttgctga actgttacat cagtgttggg aagctgatgc caagaaacgg     1020

ccatcattca agcaaatcat ttcaatcctg gagtccatgt caaatgacac gagccttcct     1080

gacaagtgta actcattcct acacaacaag gcggagtgga ggtgcgaaat tgaggcaact     1140

cttgagaggc taaagaaact agagcgtgat ctcagcttta aggagcagga gcttaaagaa     1200

cgagaaagac gtttaaagat gtgggagcaa aagctgacag agcagtccaa caccccgctt     1260

ctcttgcctc ttgctgcaag aatgtctgag gagtcttact ttgaatctaa aacagaggag     1320

tcaaacagtg cagagatgtc atgtcagatc acagcaacaa gtaacgggga gggccatggc     1380

atgaacccaa gtctgcaggc catgatgctg atgggctttg gggatatctt ctcaatgaac     1440

aaagcaggag ctgtgatgca ttctgggatg cagataaaca tgcaagccaa gcagaattct     1500

tccaaaacca catctaagag aagggggaag aaagtcaaca tggctctggg gttcagtgat     1560

tttgacttgt cagaaggtga cgatgatgat gatgatgacg gtgaggagga ggataatgac     1620

atggataata gtgaatgaaa gcagaaagca aagtaataaa atcacaaatg tttggaaaac     1680

acaaaagtaa cttgtttatc tcagtctgta caaaaacagt aaggaggcag aaagccaagc     1740

actgcatttt taggccaatc acatttacat gaccgtaatt tcttatcaat tctactttta     1800

tttttgctta cagaaaaacg gggggagaat taagccaaag aagtatattt atgaatcagc     1860

aaatgtggtg cctgattata gaaatttgtg atcctatata caatatagga cttttaaagt     1920

tgtgacattc tggctttttc ttttaatgaa tactttttag tttgtatttg actttatttc     1980

ctttattcaa atcattttta aaaacttaca ttttgaacaa acactcttaa ctcctaattg     2040

ttctttgaca cgtagtaatt ctgtgacata cttttttttt cttatagcaa tacactgtaa     2100

tatcagaaat ggttggcctg agcaacctag taagacctcg tctctactaa taattaaaaa     2160

actagctggc atggtagcac acacctgtag tcccagatac ttgggaggcc aaggcaggag     2220

gattgcttga gacctagcaa tcagtcaggg ctgcagtgag ccatgatggc accactgcac     2280

tctagcctgg gcaagagaac aagatcctgt ct                                   2312


<210> 4287
<211> 4509
<212> DNA
<213> Homo sapiens

<400> 4287
gaaggcggct gtggtagcgg cggcggcggc ggcggagccc tgggtcggtg tctgcgcgct       60

ggtgtctgag gcccaggctg aggcctccgc tattgctgga gcgcaggcgg cggagaggat      120

gactgccgct gccattctct cttgagctag cgagccgccg ccaccctcca ccctcccccg      180

gcagggcgga gaggagcggc cggagtcagc gatggtgccc ggcgaggaga accaactggt      240

cccgaaagag atagaaaatg ctgctgaaga acctagagtc ttatgtatta tacaagatac      300

tactaattca aagacagtga atgaacggat cactttaaat ttaccagcat ctactccagt      360

cagaaagctc tttgaagatg tggccaacaa agtaggctac ataaatggaa cctttgactt      420

ggtgtgggga aatggaatca atactgctga tatggcacca ctggatcata ccagtgacaa      480

gtcacttctc gacgctaatt ttgagccagg aaagaagaac tttctgcatt tgacagataa      540

agatggtgaa caacctcaaa tactgctgga ggattccagt gctggggaag acagtgttca      600

tgacaggttt ataggtccgc ttccaagaga aggttctggg ggttctacca gtgattatgt      660

cagccaaagc tactcctact catctatttt gaataaatca gaaactggat atgtgggact      720

agtaaaccaa gcaatgactt gctatttgaa tagccttttg caaacacttt ttatgactcc      780

tgaatttagg aatgcattat ataagtggga atttgaagaa tctgaagaag atccagtgac      840

aagtattcca taccaacttc aaaggctttt tgttttgtta caaaccagca aaaagagagc      900

aattgaaacc acagatgtta caaggagctt tggatgggat agtagtgagg cttggcagca      960

gcatgatgta caagaactat gcagagtcat gtttgatgct ttggaacaga aatggaagca     1020

aacagaacag gctgatctta taaatgagct atatcaaggc aagctgaagg actacgtgag     1080

atgtctggaa tgtggttatg agggctggcg aatcgacaca tatcttgata ttccattggt     1140

catccgacct tatgggtcca gccaagcatt tgctagtgtg gaagaagcat tgcatgcatt     1200

tattcagcca gagattctgg atggcccaaa tcagtatttt tgtgaacgtt gtaagaagaa     1260

gtgtgatgca cggaagggcc ttcggttttt gcattttcct tatctgctga ccttacagct     1320

gaaaagattc gattttgatt atacaaccat gcataggatt aaactgaatg atcgaatgac     1380

atttcccgag gaactagata tgagtacttt tattgatgtt gaagatgaga aatctcctca     1440

gactgaaagt tgcactgaca gtggagcaga aaatgaaggt agttgtcaca gtgatcagat     1500

gagcaacgat ttctccaatg atgatggtgt tgatgaagga atctgtcttg aaaccaatag     1560

tggaactgaa aagatctcaa aatctggact tgaaaagaat tccttgatct atgaactttt     1620

ctctgttatg gttcattctg ggagcgctgc tggtggtcat tattatgcat gtataaagtc     1680

attcagtgat gagcagtggt acagcttcaa tgatcaacat gtcagcagga taacacaaga     1740

ggacattaag aaaacacatg gtggatcttc aggaagcaga ggatattatt ctagtgcttt     1800

cgcaagttcc acaaatgcat atatgctgat ctatagactg aaggatccag ccagaaatgc     1860

aaaatttcta gaagtggatg aatacccaga acatattaaa aacttggtgc agaaagagag     1920

agagttggaa gaacaagaaa agagacaacg agaaattgag cgcaatacat gcaagataaa     1980

attattctgt ttgcatccta caaaacaagt aatgatggaa aataaattgg aggttcataa     2040

ggataagaca ttaaaggaag cagtagaaat ggcttataag atgatggatt tagaagaggt     2100

aatacccctg gattgctgtc gccttgttaa atatgatgag tttcatgatt atctagaacg     2160

gtcatatgaa ggagaagaag atacaccaat ggggcttcta ctaggtggcg tcaagtcaac     2220

atatatgttt gatctgctgt tggagacgag aaagcctgat caggttttcc aatcttataa     2280

acctggagaa gtgatggtga aagttcatgt tgttgatcta aaggcagaat ctgtagctgc     2340

tcctataact gttcgtgctt acttaaatca gacagttaca gaattcaaac aactgatttc     2400

aaaggccatc catttacctg ctgaaacaat gagaatagtg ctggaacgct gctacaatga     2460

tttgcgtctt ctcagtgtct ccagtaaaac cctgaaagct gaaggatttt ttagaagtaa     2520

caaggtgttt gttgaaagct ccgagacttt ggattaccag atggcctttg cagactctca     2580

tttatggaaa ctcctggatc ggcatgcaaa tacaatcaga ttatttgttt tgctacctga     2640

acaatcccca gtatcttatt ccaaaaggac agcataccag aaagctggag gcgattctgg     2700

taatgtggat gatgactgtg aaagagtcaa aggacctgta ggaagcctaa agtctgtgga     2760

agctattcta gaagaaagca ctgaaaaact caaaagcttg tcactgcagc aacagcagga     2820

tggagataat ggggacagca gcaaaagtac tgagacaagt gactttgaaa acatcgaatc     2880

acctctcaat gagagggact cttcagcatc agtggataat agagaacttg aacagcatat     2940

tcagacttct gatccagaaa attttcagtc tgaagaacga tcagactcag atgtgaataa     3000

tgacaggagt acaagttcag tggacagtga tattcttagc tccagtcata gcagtgatac     3060

tttgtgcaat gcagacaatg ctcagatccc tttggctaat ggacttgact ctcacagtat     3120

cacaagtagt agaagaacga aagcaaatga agggaaaaaa gaaacatggg atacagcaga     3180

agaagactct ggaactgata gtgaatatga tgagagtggc aagagtaggg gagaaatgca     3240

gtacatgtat ttcaaagctg aaccttatgc tgcagatgaa ggttctgggg aaggacataa     3300

atggttgatg gtgcatgttg ataaaagaat tactctggca gctttcaaac aacatttaga     3360

gccctttgtt ggagttttgt cctctcactt caaggtcttt cgagtgtatg ccagcaatca     3420

agagtttgag agcgtccggc tgaatgagac actttcatca ttttctgatg acaataagat     3480

tacaattaga ctggggagag cacttaaaaa aggagaatac agagttaaag tataccagct     3540

tttggtcaat gaacaagagc catgcaagtt tctgctagat gctgtgtttg ctaaaggaat     3600

gactgtacgg caatcaaaag aggaattaat tcctcagctc agggagcaat gtggtttaga     3660

gctcagtatt gacaggtttc gtctaaggaa aaaaacatgg aagaatcctg gcactgtctt     3720

tttggattat catatttatg aagaagatat taatatttcc agcaactggg aggttttcct     3780

tgaagttctt gatggggtag agaagatgaa gtccatgtca cagcttgcag ttttgtcaag     3840

acggtggaag ccttcagaga tgaagttgga tcccttccag gaggttgtat tggaaagcag     3900

tagtgtggac gaattgcgag agaagcttag tgaaatcagt gggattcctt tggatgatat     3960

tgaatttgct aagggtagag gaacatttcc ctgtgatatt tctgtccttg atattcatca     4020

ggatttagac tggaatccta aagtttctac cctgaatgtc tggcctcttt atatctgtga     4080

tgatggtgcg gtcatatttt atagggataa aacagaagaa ttaatggaat tgacagatga     4140

gcaaagaaat gaactgatga aaaaagaaag cagtcgactc cagaagactg gacatcgtgt     4200

aacatactca cctcgtaaag agaaagcact aaaaatatat ctggatggag caccaaataa     4260

agatctgact caagactgac tctgatagtg tagcattttc cctgggggag ttttggtttt     4320

aattagatgg ttcactacca ctgggtagtg ccattttggc cggacatggt tggggtaacc     4380

cagtgacacc agcactgatt ggactgccct acaccaatca gaagctcagt gcccaatggg     4440

ccactgtttt gactcggaat catgttgtgc actatagtca aatgtactgt aaagtgaaaa     4500

gggatgtgc                                                             4509


<210> 4288
<211> 1928
<212> DNA
<213> Homo sapiens

<400> 4288
cgggccatgg cggcgaacct gagccggaac gggccagcgc tgcaagaggc ctacgtgcgg       60

gtggtcaccg agaagtcccc gaccgactgg gctctcttta cctatgaagg caacagcaat      120

gacatccgcg tggctggcac aggggacagg cgagggcgtg aacgatgtgc ggaagggagc      180

ctgtgccagc cacgtcagca ccatggccag cttcctgaag ggggcccatg tgaccatcaa      240

cgcacgggcc gaggaggatg tggagcctga gtgcatcatg gagaaggtgg ccaaggcttc      300

aggtgccaac tacagctttc acaaggagag tggccgcttc caggacgtgg gaccccaggc      360

cccagtgggc tctgtgtacc agaagaccaa tgccgtgtct gagattaaaa gggttggtaa      420

agacagcttc tgggccaaag cagagaagga ggaggagaac cgtcggctgg aggaaaagcg      480

gcgggccgag gaggcacagc ggcagctgga gcaggagcgc cgggagcgtg agctgcgtga      540

ggctgcacgc cgggagcagc gctatcagga gcagggtggc gaggccagcc cccagaggac      600

gtgggagcag cagcaagaag tggtttcaag gaaccgaaat gagcaggagt ctgccgtgca      660

cccgagggag attttcaagc agaaggagag ggccatgtcc accacctcca tctccagtcc      720

tcagcctggc aagctgagga gccccttcct gcagaagcag ctcacccaac cagagaccca      780

ctttggcaga gagccagctg ctgccatctc aaggcccagg gcagatctcc ctgctgagga      840

gccggcgccc agcactcctc catgtctggt gcaggcagaa gaggaggctg tgtatgagga      900

acctccagag caggagacct tctacgagca gcccccactg gtgcagcagc aaggtgctgg      960

ctctgagcac attgaccacc acattcaggg ccaggggctc agtgggcaag ggctctgtgc     1020

ccgtgccctg tacgactacc aggcagccga cgacacagag atctcctttg accccgagaa     1080

cctcatcacg ggcatcgagg tgatcgacga aggctggtgg cgtggctatg ggccggatgg     1140

ccattttggc atgttccctg ccaactacgt ggagctcatt gagtgaggct gagggcacat     1200

cttgcccttc ccctctcaga catggcttcc ttattgctgg aagaggaggc ctgggagttg     1260

acattcagca ctcttccagg aataggaccc ccagtgagga tgaggcctca gggctccctc     1320

cggcttggca gactcagcct gtcaccccaa atgcagcaat ggcctggtga ttcccacaca     1380

tccttcctgc atcccccgac cctcccagac agcttggctc ttgcccctga caggatactg     1440

agccaagccc tgcctgtggc caagccctga gtggccactg ccaagctgcg gggaagggtc     1500

ctgagcaggg gcatctggga ggctctggct gccttctgca tttatttgcc ttttttcttt     1560

ttctcttgct tctaaggggt ggtggccacc actgtttaga atgacccttg ggaacagtga     1620

acgtagagaa ttgtttttag cagagtttgt gaccaaagtc agagtggatc atggtggttt     1680

ggcagcaggg aatttgtctt gttggagcct gctctgtgct ccccactcca tttctctgtc     1740

cctctgcctg ggctatggga agtggggatg cagatggcca agctcccacc ctgggtattc     1800

aaaaacggca gacacaacat gttcctccac gcggctcact cgatgcctgc aggccccagt     1860

gtgtgcctca actgattctg acttcaggaa aagtaacaca gagtggcctt ggcctgttgt     1920

cttcccct                                                              1928


<210> 4289
<211> 291
<212> DNA
<213> Homo sapiens

<400> 4289
atgtgtcata ccagctgctc ctcgggctgc cagccagcct gctgcgcgcc cagcccctgc       60

cagccagcct gttgcgtgcc cgtgagctgc cagtcttctg tgtgtgtgcc tgtgagctgc      120

aggcccattg tgtgtgcagc cccctcctgc cagtcctccc tgtgcgtgcc tgtgagctgc      180

aggcctgtcg tgtatgcggc tccgtcctgc cagtcctctg ggtgctgcca gccctcctgc      240

accagcgtcc tctgcagacc catctcctac agtatctctt cctgctgctg a               291


<210> 4290
<211> 321
<212> DNA
<213> Homo sapiens

<400> 4290
attacacgca tgaaacactg cttatggcct gtttccgcct ctgtctcctg ggtaatgggg       60

accacaggtg cgcaccgcca cgccaggcta aagaaataaa gtgatgtact gtatgaagaa      120

gtgccgtaaa gtgatattaa attttgagaa gccaaggaag gaaacaggga aaaatgtcgc      180

catgaaggcc gagaaccgct gccgccgccg acccccgccg gccctgaacg ccatgagcct      240

gggtccccgc cgcgcccgct ccgctccgac tgccgtcgcc gccgaggccc ccgttgatgc      300

cgctgagctc ccccaacgcc g                                                321


<210> 4291
<211> 800
<212> DNA
<213> Homo sapiens

<400> 4291
gaaattattg gagaagcaca aaaggccatg ggaaacatgt gcagagatca agcagtttgg       60

ctggtccagt caagttccag gtcaaacatt tgagagccaa gggaccaaga cccgaaccct      120

gcggctgtgg ccgagaacgc tgcactgagc ctgcgcgcaa agcctctgag taaaaggaga      180

aagtaacccc ctaactaggc ctctggaggg cgaaagctgc tgcacaagtc tgcgcaggcg      240

cgccccgctg acgaacactc atcagtgcgc aggcgcccat cttagttggt cttctagtcc      300

ggtaaacaga gggcctgccc ccgacagctt ctgcttccgg gtcacgcctt gacagcggct      360

ttcaaccccc acctcagccc agcaattcgt ttggagcatg tgaacacctt gagccttgat      420

gagttccagt atgtggtata ttatgcagag cattcagagc aaatactctc tctccgagcg      480

cttaatccga acaattgctg ccatccgttc cttcccacat gataatgtag aggacctcat      540

cagaggggga gcagatgtga actgcactca tggcacactg aagcccttgc actgtgcctg      600

tatggtgtca gatgctgact gtgtggagtt acttctggaa aaaggagccg aggtgaatgc      660

cctggatggg tataaccgaa cagccctcca ctatgcagca gagaaagatg aggcttgtgt      720

ggaggtccta ttggagtatg gtgcaaaccc caatgctttg gatggcaaca gagatacccc      780

acttcactgg gcagccttta                                                  800


<210> 4292
<211> 454
<212> DNA
<213> Homo sapiens

<400> 4292
cagtggacag catctacagc tacaataact aaagaaaaac aagatcaacc taagaaagat       60

atctcaaatt atcaggtgga acaagctcaa gttcttctta agagagagaa ggaaatccca      120

ccaaccgttt tccctaatcg cagcccttgg tgccagaatc cctatgtctc tgcacatcct      180

tactgtcctc tgattgaacc acacaataca tccaccgctg gaggcagatt ggatagacag      240

cccaggactc ggtcaaccag acctaatcga gcctcagggt ctaagaaaaa gaagacatct      300

gagtcacaaa agcaataagc agtcaactca acctttaaag gcttcctatt ctttacttga      360

cttaagatga aaactacagc cacgtgaacc ctaacttgtt ggtattctgg actctcctgg      420

tagaaatgac ttaattttac tactccatac agcc                                  454


<210> 4293
<211> 1424
<212> DNA
<213> Homo sapiens

<400> 4293
gtgcggaggc tgagccggcc gcgggcgcga ccggaggcag gcagaagaaa ttagaagtgg       60

ccatggaaga agaaggatta gcagatgaag aggtgcggtt ggtccagaag aaagatacag      120

gccatatcta tgcaatgaag atattgagaa agtctgatat gcttgaaaaa gagcaggtgg      180

cccatatccg agcagaaaga gatattttgg tagaagcaga tggtgcctgg gtggtgaaga      240

tgttttacag ttttcaggat aagaggaatc tttatctaat catggaattt ctccctggag      300

gtgacatgat gacattgcta atgaagaaag acaccttgac agaagaggaa acacagttct      360

acatttcaga gactgttctg gcaatagatg cgatccacca gttgggtttc atccatcggg      420

atattaagcc agacaacctt ttattggatg ccaagggtca tgtaaaatta tctgattttg      480

gtttatgtac gggattaaag aaagctcaca ggactgaatt ttatagaaat ctcacacaca      540

acccaccaag tgacttctca tttcagaaca tgaactcaaa gaggaaagca gaaacttgga      600

agaagaacag gagacaactg gcatattcca cagttgggac accagattac attgctccag      660

aagtattcat gcagactggt tacaacaaat tgtgtgactg gtggtctttg ggagtgatta      720

tgtatgaaat gctaatagga tatccacctt tctgctctga aacacctcaa gaaacgtaca      780

gaaaagtgat gaactggaaa gaaactctgg tatttcctcc agaggtacct atatctgaga      840

aagccaagga cttaattctc agattttgta ttgattctga aaacagaatt ggaaatagtg      900

gagtagaaga aataaaaggt catccctttt ttgaaggtgt cgactgggag cacataaggg      960

aaaggccagc agcaatccct atagaaatca aaagcattga tgatacttca aattttgatg     1020

acttccctga atctgatatt ttacaaccag tgccaaatac cacagaaccg gactacaaat     1080

ccaaagactg ggtttttctc aattatacct ataaaaggtt tgaagggttg actcaacgtg     1140

gctctatccc cacctacatg aaagctggga agttatgaat gaagataaca ttcacccata     1200

accaagagaa ctcaggtagc tgcatcacca ggcttgcttg gcgtagataa caatacactg     1260

aaatactcct gaagatggtg gtgcttattg actacaagag gaaattctac aggattagga     1320

tttctaagac tactatagga attggttggc agtgccagct ggctcttttt tttaatattt     1380

tattattttt gttaacttta ttatatgaag gtactggaat aaaa                      1424


<210> 4294
<211> 1420
<212> DNA
<213> Homo sapiens

<400> 4294
agagctggag catctcgcag ccctacaact tctttgcggc gcttggtctg tctttgcgtt       60

gcgagatcag gatcggtgtg ttgctcagac accggccgaa cgccaccggc acgtctagga      120

gtctcctgtg cctggaagag gctggtttca ttcgattcta aaagaaacgg atgttgaaac      180

atttgtagca gatatactga aaggagaaaa tttatccaag aaagcaaagg aaaagagaga      240

atcccttatt aagaagataa aagatgtaaa gtctatctat cttcaggaat ttcaagacaa      300

aggtgatgca gaagatgggg aagaatatga tgaccctttt gctgggcctc cagacactat      360

ttcattagcc tcagaacgat atgataaaga cgatgaagcc ccctctgatg gagcccagtt      420

tcctccaatt gcagcacaag accttccttt tgttctaaag gctggctacc ttgaaaaacg      480

cagaaaagat cacagctttc tgggatttga atggcagaaa cggtggtgtg ctctcagtaa      540

aacggtattc tattattatg gaagtgataa agacaaacaa cagaaaggtg aatttgcaat      600

agatggctac agtgtcagaa tgaataacac tctaagaaag gatggaaaga aagattgctg      660

ttttgaaatc tctgctcctg ataaacgtat atatcagttt acagcagctt ctcccaaaga      720

tgctgaagaa tgggtacagc agctgaaatt tgtattgcaa gatatggaat ctgatattat      780

tcctgaggat tatgatgaga gaggagaatt atatgatgat gttgatcatc ctctaccaat      840

aagcaatcca ctaacaagca gtcaaccaat agatgatgaa atttatgaag aacttccaga      900

agaagaagag gacagtgctc cagtgaaagt ggaagaacaa aggaagatga gtcaggatag      960

tgtccatcac acctcagggg ataagagcac tgattatgct aatttttacc agggattgtg     1020

ggattgtact ggagcttttt ctgatgagtt gtcatttaag cgtggtgatg tgatttacat     1080

tcttagcaag gaatacaata gatatggctg gtgggtagga gaaatgaagg gagccattgg     1140

cttggtgcct aaagcctaca taatggagat gtatgatatt tgagagtcct ggaaaaggaa     1200

aattcttctg cttgtctgca aatgctttgg atttagaagc gtcatgaaag cacgagtgac     1260

agctcctaac ctctccttgt tttattaaac attacttatc tttgactgtt attttatgca     1320

gtcgctcatt aaaatattcc tctgatgtga aattaaatga aggatattaa tgtaaattag     1380

atgcaaccag ttaagttata cctgttgcta ttttgcaaag                           1420


<210> 4295
<211> 554
<212> DNA
<213> Homo sapiens

<400> 4295
gagagacccc tacgatccca ggacactgat gtggggtaac taacacccac tggaagtcta       60

cgctgagttc acaggctatg tatgacctga catgcatttt gacctgccct gtgttttgat      120

atttgaatga gttgctgatg tttacaagcc gaagctggcc gggcgtggtg gctcgcgcct      180

gtaatcccag cactttggga ggtcgaggca ggaggatcgc ttcagagtca gaggttccgg      240

ttgagatcaa gttgggagac acacccttgt tcattctcct tgagaagcag ctattatcaa      300

cagaacattg acagaacctg tgtttgggga aaggactgat ggctttgagt ctaggttgga      360

aagcacacag gaaccactgt ggtctcctct tgcaggctct gcgaagcagt ggtcttctct      420

tgtttccctg tggccagtgt ccctggagag gagctggaag ctttttggac cctgagataa      480

aggctttcct ggaggagaac actgaagtca ccagcagtgg tagcctcacc cctgaaatcc      540

agttgcggct tttg                                                        554


<210> 4296
<211> 2996
<212> DNA
<213> Homo sapiens

<400> 4296
cttctctctc acgcctagcg caatggcggc ggccgcggcg gagcagcaac agttctacct       60

gctcctggga aacctgctca gccccgacaa tgtggtccgg aaacaggcag aggaaaccta      120

tgagaatatc ccaggccagt caaagatcac attcctctta caagccatca gaaatacaac      180

agctgctgaa gaggctagac aaatggccgc cgttctccta agacgtctct tgtcctctgc      240

atttgatgaa gtctatccag cacttccctc tgatgttcag actgccatca agaacttgct      300

accgggattc ctacaggcgg taaatgactc gtgctaccag aatgatgatt ctgtcctaaa      360

atccctcgtt gagattgcag atactgttcc aaagtatttg cgtcctcact tggaagcaac      420

tctacagcta agtctaaagt tgtgtggaga cactagcctc aacaatatgc aacgccagct      480

tgcccttgaa gtgatcgtca ccctctctga gactgcagct gctatgttaa gaaaacatac      540

caatattgtt gcacagacta ttcctcagat gttagcaatg atggttgatt tggaagaaga      600

tgaggactgg gcaaatgcag atgaactaga agatgatgat tttgacagca atgcagttgc      660

aggcgagagt gctctagatc gaatggcttg cggacttggt ggaaagctcg ttctgccgat      720

gatcaaggaa cacattatgc aaatgcttca aaatcctgac tggaaatacc ggcatgcagg      780

attgatggcc ttatctgcca ttggtgaagg gtgccaccag caaatggaag gaattctaaa      840

tgagatcgta aattttgttt tactttttct ccaggatcct catccaagag taaggtatgc      900

agcctgtaat gccgtgggac agatggctac agattttgca cctggtttcc aaaagaaatt      960

tcatgagaag gtgattgcag ctctgctgca gaccatggaa gaccaaggca atcaacgtgt     1020

gcaggcccat gcagctgctg ccctcattaa ctttactgaa gactgtccca agtcactact     1080

tattccatac ttggataatt tggtgaaaca tctgcattcc attatggtac tgaagcttca     1140

agagctgatt cagaaaggca ccaagttagt tttggaacaa gttgtgacat ccattgcatc     1200

agttgccgat actgcagaag aaaaatttgt cccctactat gatttattta tgccatcact     1260

gaagcacatc gttgagaatg cggttcaaaa agaactgaga cttctgagag gaaaaactat     1320

tgaatgcatt agcctcattg gtctggctgt tgggaaggaa aaattcatgc aggatgcatc     1380

agatgtgatg cagcttttgt taaagaccca gacagacttc aatgatatgg aagatgatga     1440

tcctcagatc tcttacatga tctcagcatg ggccagaatg tgcaaaatcc ttggaaaaga     1500

atttcagcaa taccttccag tggttatggg gcctttaatg aagacggctt caattaagcc     1560

cgaagtagcc cttttagata cccaagacat ggagaatatg agtgatgatg atggttggga     1620

atttgtgaac cttggagatc agcaaagctt tggtattaaa actgcaggac tagaagaaaa     1680

atcaactgct tgccagatgt tggtttgcta tgctaaggag ttaaaggaag gctttgtgga     1740

gtacaccgaa caggttgtca aactgatggt ccctttactg aaattttatt tccacgatgg     1800

tgttcgagtg gcagcagcgg aatccatgcc tcttctcctg gagtgtgcaa gagtccgtgg     1860

tcctgagtat ctcacacaga tgtggcattt tatgtgtgat gctctaatta aggccattgg     1920

tacagaacca gattcagacg tcctctcaga aataatgcat tcttttgcaa agtgcattga     1980

agtaatggga gatggatgcc ttaataatga acactttgaa gaactgggag gtatattgaa     2040

agcaaagctt gaagaacatt ttaaaaatca agaattacga caagttaaaa gacaagatga     2100

agactatgat gaacaggtcg aagagtcact acaagatgag gatgataatg atgtttatat     2160

tctgaccaaa gtgtcagata ttttacactc aatattcagt agctacaaag aaaaggtgtt     2220

accatggttt gaacagctgc ttccattaat tgtcaacctc atttgtccac atagaccatg     2280

gccagacaga caatggggat tatgcatctt tgatgatgtc atagaacact gtagtccagc     2340

ctcatttaaa tacgcagaat atttcttaag accaatgctc caatatgtat gtgacaacag     2400

cccagaagtc aggcaagcag ctgcatatgg cctgggagtc atggcacagt acggtggaga     2460

taattatcgc cctttttgta cagaagcact tcccctgctg gtaagagtta ttcagtctgc     2520

ggattctaag accaaagaaa atgtcaatgc tacagagaac tgcatctcag cagtagggaa     2580

aatcatgaag ttcaagcctg actgtgtaaa cgttgaagag gtccttccac actggttgtc     2640

ttggcttcca ctacatgaag ataaagaaga agctgttcag actttcaatt atctgtgtga     2700

cctgattgaa agtaatcatc caattgttct tggcccaaac aataccaatc tgcccaaaat     2760

atttagtata attgcggaag gagaaatgca cgaggcaatt aaacatgaag atccttgtgc     2820

caaacgtctg gccaatgtcg ttcgccaagt acagacttct ggaggactgt ggactgagtg     2880

catagcacag ctcagtcctg agcagcaggc cgccattcag gagctcctga actctgcgtg     2940

aagggcctta atgtcaccca ccagaaaact aactccaaat aaacgcttac cctttc         2996


<210> 4297
<211> 3127
<212> DNA
<213> Homo sapiens

<400> 4297
ccatatatat tacttatttc ctctttcttt ttatcatgac tttttcatag catcttattt       60

tttggatgca tcatcttatc tttccaagga aattagggtt tttggggtct aagttttctt      120

tggttcacgt attatctggt tcctcttttt tttttttttc ctctctgtta ctccagttta      180

tctcttttat gttggaggcc ctcctcagat gccttaccca aggctatctg tctatatctg      240

agtgaggccc taaaaggcta gccaagaagt tctgtgtttg gggtggggtg gatggtagct      300

aaatggcaag ccaggctttt tggagggact cccaaatgtc tggatctgga tggctgttcc      360

ctagactgtt cagtttttct ggaaaggact tgtgccatct gctttctggg gagctgctgg      420

tattctcagg gtagggttgg gagtggtttg gcgctgagtc ccttccactg tgcctgacca      480

tggccctgca tctggatcct ctcaggactc ctgttcaggg gcccaggggg actggttttg      540

catagaggtt gcctgcagtg gtgggtgccg ccaatagggt caggctctga acttcacctt      600

tggctcctgg tgtctgcagc gcctgggtat acagggcttt tgcaggctca gtcaacctga      660

ctccttacac acccacatct gcagccttta ggtatggcat cctctgcttc cctaacccag      720

ggattggtca cacctatttg ctgctttcta gaaatgtatc agaatccctc atctgctgct      780

ggcttgcctt ccctctttct attattatgg gcttatattt ttgtttattt ttgtagagat      840

ggggcaacat aataagaccc ccttctcaaa aaaaaaaaaa ggttgagggg agtctttgct      900

aacaattgga tttagggaaa gaggggccag gaattaaaat aactacagga agtaagataa      960

ctacagggta tgcccagctg tgcccttgga ggcctgtctg gagtacagtc agtatttagt     1020

gcacggagag ctttggctgc acttgctctg gggcagatca gtcactgctg atgcgtccca     1080

tggtgcatct ctcctgatga tcttgatgct gttgcaggtg gcccatggcg ccctcagtga     1140

tggtgccatt gatgctgtgg agacacagaa ggacctcctg ggagccagtg ggctcatgct     1200

gctgcttccc cccaaaatga agagtgagga catggcagag gaggacgtgt actggctgtc     1260

ggccttgctg cagctcaagc agctcctgca ggctaagccc ttccagcctg cgcttcctct     1320

ggtggttctt gtgcctagcc caggagggga cgccgttgag aaggaagtag aagatggttt     1380

gtgaaggaag tctcgtttat gaagcagcat tgtttaataa atgggtggag gccctgggtc     1440

tgaggatggt ccagtagtgt tggggtcagg aatcactgag acagcaaccc ctgtggtgac     1500

tgtccactgc aggactgggt ggggtcagca cagtgagata tgttagcagg tgtgctgaca     1560

gcagaatgca agtgaccttc atctatgtct gtcttaaagg tctgatgcta caggacttgg     1620

tttcagctaa gctgatttca gattacactg ttaccgagat ccctgatacc attaatgatc     1680

tacaaggttc aactaaggtt ttgcaagcag tgcagtggct ggtttcccac tgcccccatt     1740

cccttgacct ctgctgccag actctcattc agtacgtcga agacgggatt ggccatgagt     1800

ttagtggccg ctttttccat gacagaagag agaggcgtct gggcggtctt gcttctcagg     1860

agcctggcgc catcattgag ctgtttaaca gtgtgctgca gttcctggct tctgtggtgt     1920

cctctgaaca gctgtgtgac ctgtcctggc ctgtcactga gtttgctgag gcagggggca     1980

gccggctgct tcctcacctg cactggaatg ccccagagca cctggcctgg ctgaagcagg     2040

ctgtgctcgg gttccagctt ccgcagatgg accttccacc cctgggggcc ccctggctcc     2100

ccgtgtgctc catggttgtc cagtacgcct cccagatccc cagctcacgc cagacacagc     2160

ctgtcctcca gtcccaggtg gagaacctgc tccacagaac ctactgtagg tggaagagca     2220

agagtccctc cccagtccat ggggcaggcc cctcggtcat ggagatccca tgggatgatc     2280

ttatcgcctt gtgtatcaac cacaagctga gagactggac gcccccccgg cttcctgtta     2340

catcagaggc gctgagtgaa gatggtcaga tatgtgtgta tttttttaaa aacgatttga     2400

aaaaatatga tgttcctttg tcgtgggaac aagccaggtt gcagacgcag aaggagctac     2460

agctgagaga gggacgtttg gcaataaagc cttttcatcc ttctgcaaac aattttccca     2520

taccattgct tcacatgcac cgtaactgga agaggagcac agagtgtgct caagagggga     2580

ggattcccag cacagaggat ctgatgcgag gagcttctgc tgaggagctc ttggcgcagt     2640

gtttgtcgag cagtctgctg ctggagaaag aagagaacaa gaggtttgaa gatcagcttc     2700

agcaatggtt gtctgaagac tcaggagcat ttacggattt aacttccctt cccctctatc     2760

ttcctcagac tctagtgtct ctttctcaca ctattgaacc tgtgatgaaa acatctgtaa     2820

ctactagccc acagagtgac atgatgaggg agcaactgca gctgtcagag gcgacaggaa     2880

cgtgtctagg cgaacgacta aagcacctgg aaaggctgat ccggagttca agggaagagg     2940

aagttgcctc tgagctccat ctctctgcgc tgctagacat ggtggacatt tgagcagcct     3000

gacctgtggg gagggggtct ctcccgaaga gtttctgttt ttactcaaaa taatgttatt     3060

ctcagatgct tgatgcactg ttggaaatgt gattaattta atcatgcaga taaaccattt     3120

aaatgtc                                                               3127


<210> 4298
<211> 2961
<212> DNA
<213> Homo sapiens

<400> 4298
gggtgacgca ggcgcagcgc gggctgcgcg cgctactgcc catccccggt tgtcccactt       60

ttgttcgcct ctcttcggcc ctctactcaa gagctccgtc tccgtctcgc cctcctcgaa      120

gtcctcgtcg cgcgcccgcg acccaggtcg ccctgaaatc tagcccgtcc gagcgcgagt      180

ccaacgccgc ggccgcacca aggccccctc agaccgtgcc atgggtgaca gtgatgacga      240

gtacgatcga aggcgcaggg acaagttcag aagagagcgc agcgactacg accgttcccg      300

cgagagagat gaaagacgtc gaggggacga ttggaatgac agagagtggg accgtggccg      360

tgagcgccgt agtcggggtg aatatcggga ctatgaccgg aatcggcgag agcgcttctc      420

gccacctcgc cacgaactca gcccgccaca gaagcgcatg aggagagact gggatgagca      480

cagctctgac ccataccaca gtggctatga gatgccctat gggggggggt gggggcccaa      540

cttatggccc ccctcagccc tggggccacc ctgacgtcca catcatgcag caccatgtcc      600

tgcctatcca ggccaggctg ggcagcattg cagagattga cctgggtgtg ccgccgcccg      660

tgatgaagac cttcaaggag tttctcctct ccctggatga ctcggtggat gagacggagg      720

ccgtcaagcg ctataatgac tacaagctgg atttccggag gcaacagatg caggatttct      780

tcctggcgca caaagatgag gagtggtttc ggtctaagta ccacccagat gaggtgggga      840

agcgtcggca ggaggcccgg ggggccctgc aaaaccgact gagggtcttc ctgtccctca      900

tggagactgg ctggtttgat aaccttctcc tggacataga caaagctgat gccattgtca      960

agatgctgga tgcagccgtg attaagatgg aaggaggcac ggagaatgat cttcgcatcc     1020

tggagcagga ggaggaggag gagcaggcag gaaagcctgg ggagcccagc aagaaagaag     1080

aaggacgggc tggagcaggc ctaggggacg gggagcgcaa aaccaacgac aaggatgaga     1140

agaaggaaga cggcaagcag gctgagaatg acagttctaa tgatgacaaa acaaagaagt     1200

cggagggtga tggggacaag gaagagaaga aagaagactc cgagaaggaa gccaaaaaga     1260

gtagcaagaa gcggaaccgg aagcacagtg gtgacgacag ctttgacgag ggcagcgtgt     1320

cagagtctga gtcggagtca gagagcggcc aggctgagga ggagaaggag gaggccgaag     1380

cgctcaagga gaaggagaag cccaaggaag aagaatggga gaagcccaag gacgccgcgg     1440

ggctggagtg caagccgcgg ccgctgcata agacctgctc cctcttcatg cgcaacatcg     1500

cgcccaacat ctcccgggcc gagatcatct ccctttgtaa aaggtaccca ggctttatgc     1560

gggtggcgct ctcagagccc cagccagaga ggaggttttt ccgtcgtggc tgggtgacct     1620

tcgaccgcag tgttaacatt aaagagatct gttggaacct gcagaacatc cgtctccggg     1680

agtgtgagct gagccctggt gtgaacaggg acctgacccg gcgcgttcgc aacatcaacg     1740

gcatcaccca gcacaagcag attgtgcgca acgacatcaa gctggcggcc aagctgatcc     1800

acacgctgga tgacaggaca cagctttggg cctcagaacc agggacgcct cccctgccca     1860

cgagcctgcc ctcgcaaaac ccgatcttga agaatatcac cgactacctg atcgaggaag     1920

taagcgccga ggaggaggag ctgctgggga gcagcggggg cgctcctcct gaggagcctc     1980

ctaaggaagg gaacccggca gagatcaacg tggagcggga tgagaagttg attaaggtct     2040

tggacaagct cctcctttac ctgcgcatcg tgcattcctt ggattattac aacacctgtg     2100

agtaccccaa cgaggacgag atgcccaatc gctgtgggat catccacgtt cgggggccca     2160

tgccacccaa ccgcatcagt cacggggaag tgctggagtg gcagaagact tttgaggaga     2220

agctcacgcc gttgctgagt gtgcgggagt cactctcaga ggaagaggcc cagaagatgg     2280

ggcgcaaaga cccagagcag gaagtggaga agttcgtcac ctccaacacg caggaactgg     2340

gcaaggataa gtggctgtgt cctctcagtg gcaagaaatt caagggtcct gagtttgtgc     2400

gcaaacatat cttcaacaag catgcagaga aaattgagga agtgaaaaag gaagtcgcgt     2460

tttttaacaa cttcctcact gatgctaagc gcccagctct gcctgagatc aagccagccc     2520

agccacctgg ccccgcccag atactccccc caggtttgac cccaggactc ccctacccac     2580

accagactcc ccagggcctg atgccctatg gtcagccccg gcccccgatc ttgggctatg     2640

gagctggtgc tgtccgccct gcagtcccca caggaggccc tccatacccc catgccccgt     2700

atggtgctgg tcgagggaac tatgatgcct tccgaggcca gggaggttat cctgggaaac     2760

ctcgcaacag gatggttcgt ggagacccaa gggccattgt ggaatatcgg gacctggatg     2820

ccccagacga tgttgatttc ttttgagccg tcccccgttc ctcagtcctg tatcatccat     2880

acttgtacta ccttgtccta tgaagctctg agaatttttt gtacgatcag ccttactgct     2940

aataaaagca cttccacagg g                                               2961


<210> 4299
<211> 1832
<212> DNA
<213> Homo sapiens

<400> 4299
gaaaggcttg gaacagctgc cggaggtgac ggagcggcgg ccccgcccgg tgcgctggag       60

gtcgaagctt ccaggtagcg gcccgcagag cctgacccag ggtacgacga agcagtcggc      120

gggagcccac ggtcgctggg cggtgtcttt aagggagggg gcggagccac gtctctggac      180

atcctgagcc caagtccccc acactcagtg cagtgatgag tgcggaagtg aaggtgacag      240

ggcagaacca ggagcaattt ctgctcctag ccaagtcggc caagggggca gcgctggcca      300

cactcatcca tcaggtgctg gaggcccctg gtgtctacgt gtttggagaa ctgctggaca      360

tgcccaatgt tagagagctg gctgagagtg actttgcctc taccttccgg ctgctcacag      420

tgtttgctta tgggacatac gctgactact tagctgaagc ccggaatctt cctccactaa      480

cagaggctca gaagaataag cttcgacacc tctcagttgt caccctggct gctaaagtaa      540

agtgtatccc atatgcagtg ttgctggagg ctcttgccct gcgtaatgtg cggcagctgg      600

aagaccttgt gattgaggct gtgtatgctg acgtgcttcg tggctccctg gaccagcgca      660

accagcggct cgaggttgac tacagcatcg ggcgggacat ccagcgccag gacctcagtg      720

ccattgcccg aaccctgcag gaatggtgtg tgggctgtga ggtcgtgctg tcaggcattg      780

aggagcaggt gagccgtgcc aaccaacaca aggagcagca gctgggcctg aagcagcaga      840

ttgagagtga ggttgccaac cttaaaaaaa ccattaaagt tacgacggca gcagcagccg      900

cagccacatc tcaggaccct gagcaacacc tgactgagct gagggaacca gctcctggca      960

ccaaccagcg ccagcccagc aagaaagcct caaagggcaa ggggctccga gggagcgcca     1020

agatttggtc caagtcgaat tgaaaggact gtcgtttcct ccctggggat gtggggtccc     1080

agctgcctgc ctgcctctta ggagtcctca gagagccttc tgtgcccctg gccagctgat     1140

aatcctaggt tcatgaccct tcacctcccc taaccccaaa catagatcac accttctcta     1200

gggaggaggc aaatgtaggt catgtttttg ttggtacttt ctgttttttg tgacttcatg     1260

tgttccattg ctccccgctg ccatgctctc tcccttgttt ccttaagagc tcagcatctg     1320

tccctgttca ttacatgtca ttgagtaggt gggtagccct gatgggggtc gctctgtctg     1380

gagcataacc cacaggcgtt ttttctgcca ccccatccct gcatgcctga tccccagttc     1440

ctatacccta cccctgacct attgagcagc ctctgaagag ccatagggcc cccaccttta     1500

ctcacaccct gagaattctg ggagccagtc tgccatgcca ggagtcactg gacatgttca     1560

tcctagaatc ctgtcacact acagtcattt cttttcctct ctctggccct tgggtcctgg     1620

gaatgctgct gcttcaaccc cagagcctaa gaatggcagc cgtttcttaa catgttgaga     1680

gatgattctt tcttggccct ggccatctcg ggaagcttga tggcaatcct ggaagggttt     1740

aatctccttt tgtgagtttg gtggggaagg gaagggtata tagattgtat taaaaaaaaa     1800

aaggtatata tgcatatatc tatatataat at                                   1832


<210> 4300
<211> 1729
<212> DNA
<213> Homo sapiens

<400> 4300
gccctctcaa gctgcttcca gtgaatgcta cacacctgca ccatggtttg tccgacatcc       60

ttagccaaga tcaggattgg ctatgttgaa gagaagacaa acttggagta tattctttag      120

tacatttttc cccaaagatg ttgggttcag ttgccacaac actgccattg tcatcttcaa      180

attccagtgg aatgcctctt ggttactatc tgtctagtcc tcagattagt agagtaacta      240

tatcaacaac tggacaattg acttctaaag ctactgtagg tagctgttcc agagtggaaa      300

acagcttggg aaaacggaaa cttggaaaac ttacatcacg tggcttagta aatggcagaa      360

ctgaaatata attacaagtc tgtctaaatg caagacacgt tgttctttcc acttcatcac      420

gacgcgtctt tgtaatatgc cagccccttc tcagttccga agaaacagga tgaatcaccc      480

atgattgggg atggagaaga ttatttcctt tctttgtttg gtgattcaaa gaaacttaca      540

gcacactcaa actacactca gaaaacttta aaatactttt ctatgattct tgaagaagtt      600

ggccaattta cctccagttc tcttggagat gttgaaatag ctgaagtgaa tgtcaagggt      660

ttgttcgtga agctcattaa ctcttccctt gacaaagaaa tggcaattgg agatcatatt      720

ctccagcaaa atgtgaatgg acaaaccatt tctttgtacc gattccttcc aaacatcgta      780

atgcaggcaa attccacagt aacagtgtgg gcagcagcat ctgaagcaaa gcatcaacct      840

ccatcagatt ttctttggaa ggaacaagac aagtttagag caagtcctga ttgtataaca      900

atcctgtgca aaccgaacgg tcaagccatt gcgtggtaca cccctatcca ctggaagcaa      960

gcgtgggaaa aattagatgc tgacgttgaa tttaacagat gttcagtagt atctccaaca     1020

ttccgaaagc gtgtgtttca gtggacagca tctacagcta caataactaa agaaaaacaa     1080

gatcaaccta agaaagatat ctcaaattat caggtggaac aagctcaagt tcttcttaag     1140

agagagaagg aaatcccacc aaccgttttc cctaatcgca gcccttggtg ccagaatccc     1200

tatgtctctg cacatcctta ctgtcctctg attgaaccac acaatacatc caccgctgga     1260

ggcagattgg atagacagcc caggactcgg tcaaccagac ctaatcgagc ctcagggtct     1320

aagaaaaaga agacatctga gtcacaaaag caataagcag tcaactcaac ctttaaagta     1380

atctagtcca ccctcaacca gctactagaa aagcaaaaga gaactcaaat ccctgaggcc     1440

tgctctgcaa cctccctgct attccatgag agggtgaaga catcacattt ctatatggaa     1500

aaaggatcca aaatttgtat tgctgtagaa ttggtgaatt atagatgctt gatgaaatca     1560

caagtcctac cactcctgcc ttccaaatcc ctgcagaaaa caagcagatg gttagtatta     1620

ttcaatggat aaaattgcta tttgccttag atttctcttt ttgtaaacaa agttattttg     1680

ggtacagaac tcacaaaaga agagcacgtg caattgttta accatttta                 1729


<210> 4301
<211> 6149
<212> DNA
<213> Homo sapiens

<400> 4301
ggaaaagctc ctcggagatg agcgtgaccc cctggctcgt ggtggccgcc tgttctcact       60

aacgccatgg cggggaccgg agtgagaaac cggtgtctgt cactgactgc aaagtgagcg      120

agaagcaggc tgcgggccgt cccagcacga cgtggagccc cgcggagacc tcgagatgcc      180

ccgcggggaa gctcctggcc ccgggagacg gggggctaag gacgaggccc tgggcgaaga      240

atcgggggag cggtggagcc ccgagttcca tctgcagagg aaattggcgg acagcagcca      300

cagtgaacag caagatcgaa acagagtttc tgaagaactt atcatggttg tccaagaaat      360

gaaaaaatac ttcccctcgg agagacgcaa taaaccaagc actctagatg ccctcaacta      420

tgctctccgc tgtgtccaca gcgttcaagc aaacagtgag tttttccaga ttctcagtca      480

gaatggagca cctcaggcag atgtgagcat gtacagtctt gaggagctgg ccactatcgc      540

ttcagaacac acttccaaaa acacagatac ctttgtggca gtattttcat ttctgtctgg      600

aaggttagtg cacatttctg aacaggctgc tttgatcctg aatcgtaaga aagatgtcct      660

ggcgtcttct cactttgttg acctgcttgc acctcaagac atgagggtat tctacgcgca      720

cactgccaga gctcagcttc ctttctggaa caactggacc caaagagctg cacggtatga      780

atgtgctccg gtgaaacctt ttttctgcag gatccgtgga ggtgaagaca gaaagcaaga      840

gaagtgtcac tccccattcc ggatcatccc ctatctgatt catgtacatc accctgccca      900

gccagaattg gaatcggaac cttgctgtct cactgtggtt gaaaagattc actctggtta      960

tgaagctcct cggatcccag tgaataaaag aatcttcacc accacacaca ccccagggtg     1020

tgtttttctt gaagtagatg aaaaagcagt gcctttgctg ggttacctac ctcaggacct     1080

gattggaaca tcgatcctaa gctacctgca ccctgaagat cgttctctga tggttgccat     1140

acaccaaaaa gttttgaagt atgcagggca tcctcccttt gaacattctc ccattcgatt     1200

ttgtactcaa aacggagact acatcatact ggattccagt tggtccagct ttgtgaatcc     1260

ctggagccgg aagatttctt tcatcattgg tcggcataaa gttcgaacga gcccactaaa     1320

tgaggatgtt tttgctacca aaattaaaaa gatgaacgat aatgacaaag acataacaga     1380

attacaagaa caaatttaca aacttctctt acagccagtt cacgtgagcg tgtccagcgg     1440

ctacgggagc ctggggagca gcgggtcgca ggagcagctt gtcagcatcg cctcctccag     1500

tgaggccagt gggcaccgtg tggaggagac gaaggcggag cagatgacct tgcagcaggt     1560

ctatgccagt gtgaacaaaa ttaaaaatct gggtcagcag ctctacattg agtcaatgac     1620

caaatcatca ttcaagccag tgacggggac acgcacagaa ccgaatggtg gtggtgaatg     1680

taagaccttt acttccttcc accaaacact gaaaaacaat agtgtgtaca ctgagccctg     1740

tgaggatttg aggaacgatg agcacagccc atcctatcaa cagatcaact gtatcgacag     1800

tgtcatcaga tacctgaaga gctacaacat tccagctttg aaaagaaagt gtatctcctg     1860

tacaaataca acttcttcct cctcagaaga agacaaacag aaccacaagg cagatgatgt     1920

ccaagcctta caagctggtt tgcaaatccc agccatacct aaatcagaaa tgccaacaaa     1980

tggacggtcc atagacacag gaggaggagc tccacagatc ctgtccacgg cgatgctgag     2040

cttggggtcg ggcataagcc aatgcggtta cagcagcacc attgtccatg tcccaccccc     2100

agagacagcc agggatgcta ccctcttctg tgagccctgg accctgaaca tgcagccagc     2160

ccctttgacc tcggaagaat ttaaacacgt ggggctcaca gcggctgttc tgtcagcgca     2220

cacccagaag gaagagcaga attatgttga taaattccga gaaaagatcc tgtcatcacc     2280

ctacagctcc tatcttcagc aagaaagcag gagcaaagct aaatattcat attttcaagg     2340

agattctact tccaagcaga cgcggtcggc cggctgcagg aaagggaagc acaagcggaa     2400

gaagctgccg gagccgccag acagcagcag ctcgaacacc ggctctggtc cccgcagggg     2460

agcgcatcag aacgcacagc cctgctgccc ctccgcggcc tcctctccgc acacctcgag     2520

cccgaccttc ccacctgccg ccatggtgcc cagccaggcc ccttacctcg tcccagcttt     2580

tcccctccca gccgcgacct cacccggaag agaatacgca gcccccggaa ctgcaccgga     2640

aggcctgcat gggctgccct tgtccgaggg cttgcagcct tacccagctt tcccttttcc     2700

ttacttggat acttttatga ccgttttcct gcctgacccc cctgtctgtc ctctgttgtc     2760

gccatcgttt ttgccatgtc cattcctggg ggcgacagcc tcttctgcga tatcaccctc     2820

aatgtcgtca gcaatgagtc caactctgga cccaccccct tcagtcacca gccaaaggag     2880

agaggaggaa aagtgggagg cacaaagcga ggggcacccg ttcattactt cgagaagcag     2940

ctcacccttg cagttaaact tacttcagga agagatgccc agaccctctg aatctccaga     3000

tcagatgaga aggaacacgt gcccacaaac tgagtattgt gttacaggca acaatggcag     3060

tgagagcagt cctgctacta ccggtgcact gtccacgggg tcacctccca gggagaatcc     3120

atcccatcct actgccagcg ctctgtccac aggatcgcct cccatgaaga atccatccca     3180

tcctactgcc agcacactgt ccatgggatt gcctcccagc aggactccat cccatcctac     3240

tgccactgtt ctgtccacgg ggtcacctcc cagcgaatcc ccatccagaa ctggttcagc     3300

agcatcagga agcagcgaca gcagtatata ccttactagt agtgtttatt cttctaaaat     3360

ctcccaaaat gggcagcaat ctcaggacgt acagaaaaaa gaaacatttc ctaatgtcgc     3420

cgaagagccc atctggagaa tgatacggca gacacctgag cgcattctca tgacatacca     3480

ggtacctgag agggttaaag aagttgtact aaaagaagac ctggaaaagc tagaaagtat     3540

gaggcagcag cagccccagt tttctcatgg gcaaaaggag gagctggcta aggtgtataa     3600

ttggattcaa agccagactg tcactcaaga aatcgacatt caagcctgtg tcacttgtga     3660

aaatgaagat tcagctgatg gtgcggccac atcctgtggt caggttctgg tagaagacag     3720

ctgttgagtg actgtgagga tgaaccttca taccctttcc aagacgtgtt acacagacag     3780

acctttttaa gtcctggact tttaaatgac catgaagtta tcattgaatg ttaagatttt     3840

ttcttcttga ttttttaata cacgtaatct ttttgaagca gacattgtat acagaatctt     3900

acttctcttt gttcctgata tattaaaatg gccagttagg ctctttttgt agttgaattg     3960

tcttctaaag agattggatg gcctctaaag aggtatgtgt atctttattt cagatgtcac     4020

ccagagtaaa ttataattag aagtatagct agaatgagcc ccaaacctta gcctcattta     4080

ttttgttctg ttacataagt cattttcccc ttagagtgct tgaagaaatg ccacctacag     4140

gttgtgtact tttcataatg gtttccatga atgtagtacg ttcatacagg cttcattcaa     4200

cctggcgttc ccctccataa ttaagatgaa acattccggt tttctcacaa cacattagca     4260

catactgtcc attagcatat ctgggataac caggttttgg gggttgagtt ttggccttca     4320

tccttgtaga tccctttcct attgatttcc caccttccag tgaaattctg aaagtcttat     4380

cttaaaaatc gatccgctta ccatgggcct attcttgtaa gtttcagtta gcatttgcat     4440

gtgtaatatt aaaatgaaag agcttcttac ccagtgctgt tgcccttttg agtatttttg     4500

tttttaaaat aatgattgta aaatgtttta caagtaatgt aaaagctagt atcattctta     4560

catacttctg tgtttaaatt ttcattctta ccaaaacagt taactctttc tttccaatca     4620

atttatacaa aagaggtcgc tccagcccta ccacaggtct gactggcact gccttttgtt     4680

tgcccttgaa cagggcagtg ttgtggggac tgcaaaagag aaaacgtcca ggcgagccca     4740

gttgtcctcg cccacagggt cctgcaggct ccatcagtca ccgctttcta tggcgtttgt     4800

agttgtgtct tttaagaagt gagtgtgatt gtttacttga taaatcagct cactctctgg     4860

tgctttttag agaagtccct gattccttct taaacttgga atgatagatg aaattcacac     4920

ccctgcagat cagaaaaaac aaatagaaga aaatgagggt tacagtaacc tgttgtcttt     4980

atataacttg caacaaacta atttattttt ttttcctttt tttgtttttg gttttttatg     5040

gttttttaag gaaaatactt ttctcctttg aagttttaca gctttttgta aatgcgtcct     5100

gataatgatt aggaaaatcg accttttcat ccatgatgac catcctcata gctcagatct     5160

cctttcaaag tagtggcttt ctggatggta attccatctt aaggtgtcag aactattttc     5220

aaatgctgcc tttgacagtt cttggaattt tctgatatta agcagttcca tgcaaatatt     5280

cgtgttttat aaatagctct catagtctgc tccatcttga tagttaagtg atttctgaag     5340

cgtttgtgtg tgtgttgatc aggttgtgtg atatttttgc ttgatagaga atcaaatttg     5400

aaacaattaa ccagccagta gattgtctgt cagtgacctt ctgtagtaat aaagtttttg     5460

ccactgtaaa taaaaacagt atccgtagct atcaggatca ttgcgcactc atatatgcta     5520

agccttctgt tctctaatag aagcctttct tttccattgt ttctggatat ttgtattatc     5580

caaatgtgct tatttctttg ccttagcaca cgttttatgg agtacttgtt atactaggtt     5640

tgatttgaaa ctggtgcttg tcgcagaact gtcagagcat gaggagcgct cctcctgtgg     5700

gtggacgcat tcacgcactc ccaggttgca cctgctgctg gcggtgagca gggggttcag     5760

cagcttgacc gatgcccccc gagggggctc tccccagctt aaactttgtt gtttaaattt     5820

gttaactttt tatattaatg actattgaaa gtggtaataa aaatttatat tataggcttc     5880

aatgttttca tgaatgttac ccaaaaagct gtgttttctt tggtcagagg tcaaaattta     5940

tgaaaaacaa aatgctgtat gaatggaaat cattttgcaa ttgagtgaca cttcattgta     6000

attcacagtg taaatttaat ccaaactgaa attttgtttc aactgaattt gtaattaact     6060

ctgaatttgt ttttaatcat tagtaatatt tcagttgggt atctttttaa gtaaaaacaa     6120

caaataaact ctgtacatgt aaaacgtga                                       6149


<210> 4302
<211> 8189
<212> DNA
<213> Homo sapiens

<400> 4302
gcggcggcgg ccaaactccg cggcgtcccc agggcgccag cttcgccctc gccgccgcgg       60

ccgcgctgct cttcggctcc gacatggaag atggaccttc taataatgcg agctgcttcc      120

gaaggctgac cgagtgcttc ctgagcccca gtttgacaga tgaaaaagtg aaggcatatc      180

tttctcttca cccccaggta ttagatgaat ttgtatctga aagtgttagt gcagagacag      240

tagagaaatg gctgaagagg aagaacaaca aatcagaaga tgaatcagct cctaaggaag      300

tcagcaggta ccaagatacg aatatgcagg gagttgtata tgaactaaac agctatatag      360

aacaacggtt ggacacagga ggagacaacc agctactcct ctatgaactg agcagcatca      420

ttaaaatagc cacaaaagcc gatggatttg cactgtattt ccttggagag tgcaataata      480

gcctgtgtat attcacgcca cctgggataa aggaaggaaa accccgcctc atccctgctg      540

ggcccatcac tcagggcacc accgtctctg cttatgtggc caagtccagg aaaacactgc      600

tagtagaaga catccttgga gatgaacgat ttccaagagg tactggactg gaatcaggga      660

ctcgtatcca gtctgttctt tgcttaccaa ttgtcactgc aattggtgac ttgattggta      720

ttctcgagct gtatcggcac tggggcaaag aagccttctg tcttagtcac caggaggttg      780

caacagcaaa tcttgcctgg gcttcagtag caatacatca ggtgcaggta tgcagaggcc      840

ttgccaaaca gacagaattg aatgacttcc tactcgacgt atcaaaaaca tattttgata      900

acatagttgc aatagattct ctacttgaac acataatgat atatgcaaaa aacctggtga      960

atgccgatcg ttgtgcgctt ttccaggtgg accataagaa caaggagtta tattcagacc     1020

tttttgatat tggagaggaa aaggaaggaa aacctgtctt caagaagacc aaagagataa     1080

gattttcaat tgagaaagga attgctggcc aagtagcaag aacaggggaa gtcctgaaca     1140

ttccagatgc ctatgcagac ccacgcttta acagagaagt agacttgtac acaggctaca     1200

ccacgcggaa catcctgtgc atgcccatcg tcagccgagg cagcgtgata ggtgtggtgc     1260

agatggtcaa caaaatcagt ggcagtgcct tctctaaaac agatgaaaac aacttcaaaa     1320

tgtttgccgt cttttgtgct ttagccttac actgtgctaa tatgtatcat agaattcgcc     1380

actcagagtg catttaccgg gtaacgatgg aaaagctgtc ctaccatagc atttgtactt     1440

cagaagagtg gcaaggtctc atgcaattca cccttcccgt gcgtctctgc aaagaaattg     1500

aattattcca ctttgacatt ggtccttttg aaaacatgtg gcctggaatt tttgtctaca     1560

tggttcatcg gtcctgtggg acatcctgct ttgagcttga aaagttgtgt cgttttatta     1620

tgtctgtgaa gaagaactat cggcgggttc cttatcacaa ctggaagcat gcggtcactg     1680

tagcacactg catgtatgcc atacttcaga acaatcacac gcttttcaca gaccttgagc     1740

gcaaaggact gctgattgcg tgtctgtgtc atgacctgga ccacaggggc ttcagtaaca     1800

gctacctgca gaagttcgac caccctctgg ccgctctcta ctccacttcc accatggagc     1860

agcaccactt ctcccagact gtgtccatcc tccagttgga agggcacaat atcttctcca     1920

ctctgagctc cagtgaatat gagcaggtgc ttgagatcat ccgcaaagcc atcattgcca     1980

cagaccttgc tttatacttt ggaaacagga agcagttgga agagatgtac cagaccggat     2040

cactaaacct taataatcaa tcacatagag accgtgtaat tggtttgatg atgactgcct     2100

gtgacctttg ttctgtgaca aaactgtggc ccgttacaaa attgacggca aatgatatat     2160

atgcagaatt ctgggctgag ggtgatgaaa tgaagaaatt gggaatacag cctattccta     2220

tgatggacag agacaagaag gatgaagtcc cccaaggcca gcttgggttc tacaatgccg     2280

tggccattcc ctgctataca acccttaccc agatcctccc tcccacggag cctcttctga     2340

aagcatgcag ggataatctc agtcagtggg agaaggtgat tcgaggggag gagactgcaa     2400

cctggatttc atccccatcc gtggctcaga aggcagctgc atctgaagat tgagcactgg     2460

tcaccctgac acgctgtccc acctacagat cctcatcttg cttctttgac attcttttcc     2520

tttttttggg gggggtgggg ggaacctgca cctggtaact ggggtgcaaa cctcttcaag     2580

aaggtaacat caaataaata agtcaagcag aggacttcct gccaatctct tctgtgaggc     2640

atcatagaca ctgagcaacc aggaccaccc ccacgttcag aaatcagctg gccaagtgac     2700

tccatttgac ttgcaaacca gccttttcta ataggctaat attgctgagg ccttaaagga     2760

aatggacaaa aattatccag aaggggtact tttccattgt atctttctaa taagggttta     2820

aaatggtact attatggtat tgtacttggg ctttaacatc aatgttgctt tgatgttgtt     2880

ggatataaat aggaattttt acacattact attgtgaatg gtgaatgttc atgtatgacc     2940

tacttgtaat taacttgagt tgtagtccac agcctcagga caaatgtcgt tgaggttaca     3000

gagtaagaaa tgatggcaaa acgtcaaact cttatttcag agcttcatga atttagttag     3060

actaaacata attctttaag ttcaacctaa agggctgaga tcaataaatt taacactaga     3120

cgaagtagac ttcctgtctt tttgagaaga gatgaggtat atgttacaat aaatctcaga     3180

acttcaagta gcagttcaaa agatgtcagt ttttaaaatt gtttttgttg ttgtcttggc     3240

agttttactg aaccctttgc ataaagaaca aaataaaagc tcggcattgt aattttttta     3300

atggacaagt cttatggata cgaagggtac atttttcata atgattcctt tatattttca     3360

ctttgtgtca ttgcagaatt ttagactctc attcacaatg aaaagtttat tttaaacatt     3420

gtttaattaa aataccatac agttctcttt taaacatcaa accataaaaa gtgtattttg     3480

taattttact ctgacctgcc gcagtcacct ctcacttatc tcttccacgt actgcacggt     3540

cgtatttcat gagctttctg tccatagcac agaaacagag cagaaagtag tacaatcatg     3600

ttggaccttc tttctgttct ctttactctt ctcacagatc agatcactcc atagaagcct     3660

gtgggtttcg atggtttctt ctatacacct ttttggttga ccagtattac tatacaatgt     3720

aagtgtttta aaaaatacga aagtaatact ctgcacccct tcctacaaag atgataaagc     3780

agtcacttct ggcgcatttt aataatttaa agatttttag tgcaatggca cggtaacctc     3840

caaacctgaa ttagacagag actcactcag gaagtgacag gcccatcata tcaaataact     3900

tattcacttt tcatgtggca ggaaactgga atatcgcttt taataaaatg gaaaaatatg     3960

cttctacata tttaccacca taggcgtttt gttcatatga gcctggtttg tgcaaaatta     4020

aatcagaggc ttctacaaca tggtttattt atgttgtagc aaagttggct ctacataaac     4080

attgttctta ttttaaaatt aacactatgt gttcagtttt cttgtgggct tctgaaagtt     4140

gccatcttcc ctccgtggag ctccatttgc tattttcatt atacactatg aggtaaaatg     4200

taataacaaa agagagagaa gtaccactgt ggctagatat atacacacac atatatatat     4260

ggatggatgt aatatatgta gaacacacac atagatgtat ataggataca cactcatgta     4320

tgtaaacgta tacatatgtg tatatatgat acatacacat acacacacac gagagacaga     4380

aggaaagaga ggaagagaga agcaaacatg taggaaaaaa tataaatcag ccccattctc     4440

ccattcttta agaacaatga tttttcttga tggaaaatgc atatcacttg acagttgaca     4500

agaaagtgtc atttttgtgt tagtgtatca tataattgaa tttgaacaag atacatattt     4560

ttctgcatac aaatttatga agctggagtc taccaaacac agctttagtc acaaaagtta     4620

gtttagttat ctcatttcgc ttggagatgg aatttcagga agggatatat tatttaagat     4680

tattgtttaa ttacaagaat tttaaaagaa tgtatgaatt ctgtttttta atatagaaaa     4740

taattatgga gttaggaatc tcatggctac atttacattt ttaggttatt acagaaaatt     4800

ctcttaattt attatagtca agtgtattat gtaatctcta tttagaacag tttcccaaag     4860

gaatgtgatt ggatttactg gttggttaat ttcttgtgaa atattgtcat aatagaagca     4920

cagcttgaac aaaagactga attctgatat aaactgtcaa tattgctttt accatgtgta     4980

agatttactt agtaatcaca gatttaccta aaataaaagg acccgggttg cagtgatatt     5040

tagttaatga tttgttttgg aaaacatgca gttaggagta tttttgtatt ttgtcagatg     5100

tttaggagac agactttcgg gtcatgtttc ttgtcttgtt cccagatctt ttcttaaaag     5160

aacagtgtga caccagaagc caagagatgg tttttactaa caacagcttt gatgagttcc     5220

tattaaggtc gtattgtgta ttgtgccaaa ttttccaccc agtataaatt tagtaacccg     5280

ctatgagcat atgtaggata ttcaatttgc agatactttt gttggttatg ttggtttata     5340

atagacaagt tttatggtca tatgcaatta ttccattatc tttttggaca cagtgaatat     5400

gttttttagc taaaaatgtc cttggaaaca taaatgcctg ccaataacat ggaatattga     5460

attcgggcaa tgtgaattga ttaattagaa aagggtcaaa agaaatacaa tggatgtgga     5520

aactaattct aaaaaatagc cctattaata gggcagagac tctggtccat ttcccagctg     5580

tacttctctc taagaggtgt atgaaaaacc catcttgcaa aagagaccaa aatattagac     5640

acaatcgttc ccattcctga ctcttcaatg gaaaaggaag gtacagatgt ttacagtggt     5700

gccccaggtg actcgttctc accacaacaa aagcaactaa ttggaaacta gatgtgttca     5760

ataatagatt tcctcttttt tggcatgctt tttagatttt ttttcatttt gtaaaatctc     5820

agttaatttt tctttattgg tatatttgtg tatgcgagac aaatcctgta ttgtacagga     5880

tataaataga tgcataaatc cttagatacc tgggtttttt aataggttta ggtttgggta     5940

ttgtgtttct ggtcttttaa ctcaaaatta aggtttgagc tttaatagga ctaaattatt     6000

cacctgcctt ggcctgtgcc tttattttaa atactgcaat tttacttctt cattcatgta     6060

tttattattt tgcttttctt gcttaagtat aattgaaaat atttgcagga acgcacaatt     6120

cattttatca agttgaatga ataggaccat tctctcctca tcagatttct gttctttatt     6180

tgacttcatt gacatatacc ctggtgacta taaccagtga actgttcaga gtcagtcttt     6240

tcggcaagaa cttcagagaa ctgtgacact ggttatgatg tgattttggg gggtttcagg     6300

tacctaagca tgatttttaa aatcacttct ctctttacat atttcgaaca tatgtttgct     6360

ttctacactt tgcagatttt atttaggatt taattcttta aagactatat tcatttagtc     6420

actatagtgg atctcttcta ctgcaagtat tcatctgatt tttaaattat gtaaaatgta     6480

aatcagccaa gtatgtcatc cgttatagtt tccccatgct ttcagcgcat ggccatgaga     6540

tttttacatg tgcataagta tttagccaat acacattttg ctgacttctt taaccattta     6600

tattgtttaa attagtaata tccaatgcag tgcacacttt tttgtctttt ttccaacgga     6660

atattttggt tgtctgtagc gttggaagca ttttatatga taaaaatagc aagaaaaaat     6720

taaaaagtgt caacggtgtg ctggttctaa attaagaaga tagaacaaag agaaagacat     6780

taatgttacc taagaaacac atttaacatc cgaagaagca atgctgtcct cacttgatgt     6840

ttctcttctc aacccagcaa tggagagcag ggcttgcaaa gccgtacaga gcctacgtgc     6900

tctttcctgc aagtgggaga aaactaatca atggcacaca gggccaggtg tggccctgtg     6960

aggcaaagga taatgtcacc tcaggaccaa ggtggaaact tacagctgaa tccagggctt     7020

actaagtagg gaagtcagtt tacatatttc agttttcctc tgatgttttt gaggtactgt     7080

gtatttgcag aagtttaagc agaagggttt tgtttctatt gtaagttagg ttctaaaagt     7140

gtataatctg atactctagc ccaactgaaa tattatatct tgggcgttac agcctttgtc     7200

tttttcttta gtcaccttaa tacccagtcc tatgctgtat ctctgatagc ctatataaat     7260

gacatatagg aatattattt tccatatgat ctgttgtatg gtgtatatgc tatgtgttca     7320

tttcgtgtgc aagttcagag tgtaatagat ttacccagag aaggtgtttc tatacaatgc     7380

ccctacctat ttgaaattac atgcttgccc aacacactgt gaaatagtta ccaaaatttg     7440

tacaaatgca gcatcttcat tctttctgag aagacaagat ggttttcttt acatgaacaa     7500

atgaacaaaa gagatcctag atccataacg tagctaaggc atctaagagt ttgctgttga     7560

taatcttgct gaccaaaaac tactggagag taacacaggt tatatgccat cacaaataca     7620

atgctcatga agaactgatt tgtagagtca atgaacctgt gtccagaatt ttaataggct     7680

ctctattgga aggagaaaga atttcaagtt aacagtatct aactttatca tagttgatgt     7740

tagtaaattt taaaaaatga ttttatatgt atgacaaaaa tctttgtaaa atgcgcaagt     7800

gcaataattt aaagaggtct taactttgca tttataaatt ataaatattg tacatgtgtg     7860

taattttttc atgtattcat ttgcagtctt tgtatttaaa aaacatttac tgttatgttt     7920

gtataataga acagtaatca tttattataa tctaggcaag ttgtaaataa attcataatt     7980

caaacagcca gtatatatgc atatatgagt gttatattgc aaaatctttg ttttacttac     8040

atggttaaag cagcaagaat tcttttgttg atatgtaatt atacacataa aatatatata     8100

tgtatgatac atgaaatata tttagaaatg ttcataattt taatggatat cctttggtgt     8160

gaataattga atacagagtt tttaaaata                                       8189


<210> 4303
<211> 2191
<212> DNA
<213> Homo sapiens

<400> 4303
aacaagttaa gctgaagacc gaagcaagag ctggttcagg tggcagccac agcagcctca       60

gggacctcag caactatggc ctcctgccca gactctgata atagctgggt gcttgctggc      120

ggggagctgg gcatctccct caacatgtgc ctccttgggg ccctggttct gcttggcctg      180

ggggtcctcc tcttctcagg tggcctctca gagtctgaga ctgggcccat ggaggaagtg      240

gagcggcagg tcctcccaga ccccgaggtg ctggaagctg tgggggacag gcaggatggg      300

ctaagggaac agctgcaggc cccagtgcct cctgacagtg tccccagcct gcaaaacatg      360

ggtcttctgc tggacaagct ggccaaggag aaccaggaca tccggctgct gcaggcccag      420

ctgcaggccc aaaaggaaga gcttcagagc ctgatgcacc agcccaaagg gctagaggag      480

gagaatgccc agctccgggg ggctctgcag cagggcgaag ccttccagcg ggctctggag      540

tcagagctgc agcagctgcg ggcccggctc caggggctgg aggccgactg tgtccggggc      600

ccagatgggg tgtgcctcag tgggggtaga ggcccacagg gtgacaaggc catcagggag      660

caaggcccca gggagcagga gccagaactc agcttcctga agcagaagga acagctggag      720

gctgaggcac aggcattaag gcaagagtta gagaggcagc gacggctgct ggggtctgta      780

cagcaggatc tggagaggag cttgcaggat gccagccgcg gggacccagc tcatgctggc      840

ttggctgagc tgggccacag attggcccag aaactgcagg gcctggagaa ctggggccag      900

gaccctgggg tctctgccaa tgcctcaaag gcctggcacc agaagtccca cttccagaat      960

tctagggagt ggagtggaaa ggaaaagtgg tgggatgggc agagagaccg gaaggctgag     1020

cactggaaac ataagaagga agaatctggc cgggaaagga agaagaactg gggaggtcag     1080

gaggacaggg agccagcagg aaggtggaag gagggcaggc caagggtgga ggagtcgggg     1140

agcaagaagg agggcaagcg acagggcccg aaggaacccc caaggaaaag tggtagcttc     1200

cactcctctg gagaaaagca gaagcaacct cggtggaggg aagggactaa ggacagccat     1260

gaccccctgc catcctgggc agagctgttg aggcccaagt accgggcacc ccagggctgc     1320

tcaggtgtgg acgagtgtgc ccggcaggag ggcctgactt tctttggcac agagctagcc     1380

ccagtgcggc aacaggagct ggcctctctg ctaagaacat acttggcacg gctgccctgg     1440

gctgggcagc tgaccaagga gctacccctc tcacctgctt tctttggtga ggatggcatc     1500

ttccgtcatg accgcctccg cttccgggat tttgtggatg ccctggagga cagcttggag     1560

gaggtggctg tgcaacagac aggtgatgat gatgaagtag atgactttga ggacttcatc     1620

ttcagccact tctttggaga caaagcactg aagaagaggt cagggaagaa ggacaagcac     1680

tcacagagcc caagagctgc ggggcccagg gaggggcaca gccatagcca ccaccaccac     1740

caccggggct gacaccctgc cccacaggga atggccttgg cctggcccag cccaagatcc     1800

cagcgttatc taactcctgg agggtggact ctgtcctggc ttgtttggtg tcctcagata     1860

tctttcacac agtagagcaa aatcaccagc cctgcactga tgtcacttta tgtagaaaaa     1920

ggccttagct ggacctgcgt tgccgtctat gcaaatgcat gcaaatactc caggccctgg     1980

gatgtgggct tgtgttttgt cactgtgaag ggggagatgg gagaggagcc tgttttgggg     2040

tggggtctgg ggaaggcaat ctgattctga agctaaagag ctttcatcct cttgagtgta     2100

tgtccccata gtgggcccct tgacccacat gctgaccggt gccttgggat ttgactagag     2160

ttgctggctc gaggcccagc acgaggactt a                                    2191


<210> 4304
<211> 2330
<212> DNA
<213> Homo sapiens

<400> 4304
ctggatttcc gaggctggag gcgcctggcc ggctgggtgg ggaccaccat gggcaacgcg       60

gccggcagcg ccgagcagcc cgcgggcccc gccgcgccgc cccccaagca gcaccgcttt      120

gaaaagctga tggaatattt ccggaatgag gacagcaaca tcgacttcat ggtggcctgc      180

atgcagttca tcaacattgt ggtacattcg gtggagaaca tgaacttccg tgtcttcctg      240

caatatgagt tcacccactt gggcctggac ctgtacttgg agaggcttcg gctcaccgag      300

agtgacaagc tgcaggtgca gatccaggcg tacctggaca atatttttga tgtgggggcg      360

ctgctggagg acacagagac caagaacgct gtgctggagc acatggagga actgcaggag      420

caagtggcgc tgctgacaga gcggcttcgg gacgcggaga acgaatccat ggccaagatt      480

gcagaactgg aaaaacagct aagccaggcg cgcaaggagt tggagaccct gcgggagcgc      540

ttcagcgaat cgaccgccat ggggccctcc aggcgtcccc cagagcctga gaaagcgcct      600

cccgctgccc cgacgcggcc ctcggccctg gagctgaagg tggaggagct ggaggagaag      660

gggttaatcc gtattctgcg ggggccgggg gatgctgtct ccatcgagat cctccccgtc      720

gctgtggcaa ctccgagcgg cggtgatgct ccgactccgg gggtgccgac cggctccccc      780

agcccagatc tcgcacctgc agcagagccg gctcccggag cagcgccacc gccgccgccg      840

ccgcctcccg gaggtcctcc tgatgcccta ggaagacgcg actcagaatt gggcccagga      900

gtgaaggcca agaagcccat ccagactaag ttccgaatgc cactcttgaa ctgggtggca      960

ctgaaaccca gccagatcac cggcactgtc ttcacagagc tcaatgatga gaaggtgctg     1020

caggagctag acatgagtga ttttgaggaa cagttcaaga ccaagtccca aggccccagc     1080

ctggacctca gcgctctcaa gagtaaggca gcccagaagg cccccagcaa ggcgacactc     1140

attgaggcca accgggccaa gaacttggcc atcaccctgc ggaagggcaa cctgggggcc     1200

gagcgcatct gccaagccat tgaggcgtac gacctgcagg ctctgggcct ggacttcctg     1260

gagctgctga tgcgcttcct gcccacagag tatgagcgca gcctcatcac ccgctttgag     1320

cgggagcagc ggccaatgga ggagctgtca gaggaggacc gcttcatgct atgcttcagc     1380

cgcatcccgc gcctgccgga gcgcatgacc acactcacct tcctgggcaa cttcccggac     1440

acagcccagc tgctcatgcc gcaactgaat gccatcattg cagcctcaat gtccatcaag     1500

tcctctgaca aactccgcca gatcctggag attgtcctgg cctttggcaa ctacatgaac     1560

agtagcaagc gtggggcagc ctatggcttc cggctccaga gcctggatgc gctgttggag     1620

atgaagtcga ctgatcgcaa gcagacgctg ctgcactacc tggtgaaggt cattgctgag     1680

aagtacccgc aactcacagg cttccacagc gacctgcact tcctggacaa ggcgggctca     1740

gtgtccctgg acagtgtcct ggcggacgtg cgctccctgc agcgaggcct agagttgaca     1800

cagagagagt ttgtgcggca ggatgactgc atggtgctca aggagttcct gagggccaac     1860

tcgcccacca tggacaagct gctggcagac agcaagacgg ctcaggctgt gcccacagga     1920

ggcctttgag tctgtggtgg agtacttcgg agagaacccc aagaccacat ccccaggcct     1980

gttcttctcc ctctttagcc gcttcattaa ggcctacaag aaagctgagc aggaggtgga     2040

acagtggaaa aaagaagccg ctgcccagga ggcaggcgct gataccccgg gcaaagggga     2100

gcccccagca cccaagtcac cgccaaaggc ccggcggcca cagatggacc tcatctctga     2160

gctgaaacgg aggcagcaga aggagccact catttatgag agcgaccgtg atggggccat     2220

tgaagacatc atcacagatc tgcggaacca gccctacatc cgcgcagaca caggccgccg     2280

cagtgcccgt cggcgtcccc cgggcccccc actgcaggtc acctccgacc                2330


<210> 4305
<211> 2031
<212> DNA
<213> Homo sapiens

<400> 4305
atagagtagc ggaagtggtc cgttctcttc ctctcccggc ccaagcttct gggtatttct       60

attgcgcgag gcattgtggg ttgctgggcg gcccggtctc ggagaagagg ggagagtggc      120

gggccgctga ataagcttcc aaaatgatgc attgctcatt cttgaagtcg tcttcatctt      180

ctgtgcagag gcagcatagt acagcagttg agagtaaggc ctctggagct acactgaatg      240

cctagcccac accagttatc ctattgaaag aggggactga tagctcccaa ggcatccccc      300

agcttgtgag taacatcagt gcctgccagg tgattgctga ggctgtaaga actaccctgg      360

gtccccgtgg catggacaag cttattgtag atggcagagg caaagcaaca atttctaatg      420

atggggccac aattctgaaa cttcttgatg ttgtccatcc tgcagcaaag actttggtag      480

acattgccaa atcccaagat gctgaggtgg gtgatggcac cacctcagtg accttgctgg      540

ctgcagagtt tctgaagcag gtgaaaccct atgtggagga aggtttacac ccccagatca      600

tcattcgagc tttccgcaca gccacccagc tggcagttaa caagatcaaa gagattgctg      660

tgaccgtgaa gaaggcagat aaagtggagc agaggaagct gctggaaaag tgtgccatga      720

ccgctctgag ctccaagctg atctcccagc agaaagcttt ctttgctaag atggtggtgg      780

atgcagtgat gatgctcgat gatttgctgc agcttaaaat gattggaatc aagaaggtac      840

agggtggagc cctcgaggat tctcagctgg tagctggtgt tgcattcaag aagactttct      900

cttacgctgg gtttgaaatg caacccaaaa agtaccacaa tcccaagatt gcccttttga      960

atgtcgagct cgagttgaaa gctgagaaag acaatgctga gataagagtc cacacagttg     1020

aggattatca ggcaattgtt gatgctgagt ggaacattct ctatgacaag ttagagaaga     1080

tccatcattc tggagccaaa gttgtcttgt ccaaactccc cattggggat gtggccaccc     1140

agtactttgc tgacagggac atgttctgtg ctggccgagt acctgaggag gatctgaaga     1200

ggacaatgat ggcctgtgga ggctcaatcc agaccagtgt gaatgctctg tcagcagatg     1260

tgctgggtcg atgccaggtg tttgaagaga cccagattgg aggcgagagg tacaattttt     1320

ttactggctg ccccaaggcc aagacatgca ccttcattct ccgtggcggc gccgagcagt     1380

ttatggagga gacagagcgg tccctgcatg atgccatcat gatcgtcagg agggccatca     1440

agaatgattc agtggtggct ggtggcgggg ccattgagat ggaactctcc aagtacctgc     1500

gggattactc aaggactatt ccaggaaaac agcagctgtt gattggggca tatgccaagg     1560

ccttggagat tatcccacgc cagctgtgtg acaatgctgg ctttgatgcc acaaacattc     1620

tcaacaagct gcgggctcgg catgcccagg ggggtacatg gtatggagta gacatcaaca     1680

acgaggacat tgctgacaac tttgaagctt tcgtgtggga gccagctatg gtgcggatca     1740

atgcgctgac agcagcctct gaggctgcgt gcctgatcgt gtctgtagat gaaaccatca     1800

agaacccccg ctcgactgtg gatgctccca cagcagcagg ccggggccgt ggtcgtggcc     1860

gcccccactg agaggcaccc cacccatcac atggctggct ggctgctggg tgcacttacc     1920

ctccttggct tggttacttc attttacaag gaaggggtag taattggccc actctcttct     1980

tactggaggc tatttaaata aaatgtaaga cttcagataa ctttgtaaat t              2031


<210> 4306
<211> 566
<212> DNA
<213> Homo sapiens

<400> 4306
aaaactctct gaagttttta tttacccagc gctctggctc ccacttctgt tttaaaagat       60

tataagtaaa tactctgctc tttcaagtga accaaaccta tcaaacctgt ttagaaaata      120

aaccaggctt tcagtccagt gtaaagctgt tggagcgcgg gagcaaaggt aaagaatgat      180

gtaatgcgct ggctgctcca aagcatcttt tgttgtggaa tggttattcc agtcatctct      240

ttatgaatca aatgtgaggg gctgctttgt ggacggagtc ctttgcaaga gcacatcaac      300

gggaaagaga aagagacatt cacttggagg gctcttgctg aaaatgggtt taactctcct      360

tttgccagtc accaccagcc tgacctcata cacttttagt acaatggagt ggctgagcct      420

ttgagcacac caccattaca tcatcgtggc aaattaaaga aggaggtggg aaaagaggac      480

ttattgttgt catggcccat gagatgattg gaactcaaat tgttactgag aggttggtgg      540

ctctgctgga aagtggaacg gaaaaa                                           566


<210> 4307
<211> 1651
<212> DNA
<213> Homo sapiens

<400> 4307
atggagaaga ctgagctgat ccagaaggcc gtggcctaca agaacgtggt cgggggccgc       60

aggtccgcct ggagggtcat ctctagcatc gagcagaaga ccgacacctc cgacaagaag      120

ttgcagctga ttaaggacta tcgggagaaa gtggagtccg agctgagatc catctgcacc      180

acggtgctgg aattgttgga taaatattta atagccaatg caactaatcc agagagtaag      240

gtcttctatc tgaaaatgaa gggtgattac ttccggtacc ttgctgaagt tgcgtgtggt      300

gatgatcgaa aacaaacgat agataattcc caaggagctt accaagaggc atttgatata      360

agcaagaaag agatgcaacc cacacaccca atccgcctgg ggcttgctct taacttttct      420

gtattttact atgagattct taataaccca gagcttgcct gcacgctggc taaaacggct      480

tttgatgagg ccattgctga acttgataca ctgaatgaag actcatacaa agacagcacc      540

ctcatcatgc agttgcttag agacaaccta acactttgga catcagacag tgcaggagaa      600

gaatgtgatg cggcagaagg ggctgaaaac taaatccata cagggtgtca tccttctttc      660

cttcaagaaa cctttttaca catctccatt ccttattcca cttggatttc ctatagcaaa      720

gaaacccatt catgtgtatg gaatcaactg tttatagtct tttcacactg cagctttggg      780

aaaacttcat tccttgattt gtgtttgtct tggccttcct ggtgtgcagt actgctgtag      840

aaaagtatta atagcttcat ttcatataaa cataagtaac tcccaaacac ttatgtagag      900

gactaaaaat gtatctggta tttaagtaat ctgaaccagt tctgcaagtg actgtgtttt      960

gtattactgt gaaaataaga aaatgtagtt aattacaatt taaagagtat tccacataac     1020

ttcttaattt ctacattccc tcccttactc ttcgggggtt tcctttcagt aagcaacttt     1080

tccatgctct taatgtattc ctttttagta ggaatccgga agtattagat tgaatggaaa     1140

agcacttgcc atctctgtct aggggtcaca aattgaaatg gctcctgtat cacatacgga     1200

ggtcttgtgt atctgtggca acagggagtt tccttattca ctctttattt gctgctgttt     1260

aagttgccaa cctcccctcc caataaaaat tcacttacac ctcctgcctt tgtagttctg     1320

gtattcactt tactatgtga tagaagtagc atgttgctgc cagaatacaa gcattgcttt     1380

tggcaaatta aagtgcatgt catttcttaa tacactagaa aggggaaata aattaaagta     1440

cacaagtcca agtctaaaac tttagtactt ttccatgcag atttgtgcac atgtgagagg     1500

gtgtccagtt tgtctagtga ttgttattta gagagttgga ccactattgt gtgttgctaa     1560

tcattgactg tagtcccaaa aaagccttgt gaaaatgtta tgccctatgt aacagcagag     1620

taacataaaa taaaagtaca ttttataaac c                                    1651


<210> 4308
<211> 2035
<212> DNA
<213> Homo sapiens

<400> 4308
aaggcctaag ccggcgccga gagagccagc cgcgttacga tggagaccga aagtggagaa       60

aaggccagct gtgggcaagg agtgcacggc cgccatcttg gttgtgggaa gtctcgtcta      120

ggctgtcctc tctccagttg ggaggaccaa gatggagcga aggatgaagt agcaagtgca      180

cgtctttctt gggagcagga tgttgcgcaa gtttacactt ctgaccccat cacactgctt      240

cccactgaga tgcaagagac ctgccccgaa tacagtacag gagcatcttc aaagtacttc      300

cagtgggtgc cctggacagc agctaagaac cccggggtaa aacgagtttc ctctctactg      360

ttacaaatca gaaacctcct ccgtaaaagc ctcagatctg ggaaacgcgg atgcatatgc      420

caacttttga gtctcagtct gcgcctgcgc acgtgacctc tacacgtctc ctctgcgcct      480

gcgccgctca agttagcgcg aggctactca gtcgagggtg ggactacgct tcgcgttttg      540

ggattgggcg ctgaaggcca aaccggacga cgcggaaatg acgtcacgcc gggggccctg      600

ccgcgcggtg gctgctgggt gccgcacgcc ttcccatcct cctcctctcc cctcccccat      660

ccctccccgc cccctcggcc gctccgctcc ctggcgtgac tcggcactga gagtcccggg      720

agaagactcg gcggtcgcca cctcttctgt ccaggcctcg gccttcctga gcatctctcc      780

ttcctctccc agatcgtctt ctccttcagt ttcaaagcca gtggcgtcgc ggccaccctg      840

ccgggctctc tgtgaggatg gtgggggtga agcccgtcgg gagcgacccg gatttccagc      900

cagagctgag cggcgcgggc tccagactcg ccgtggtcaa gttcaccatg agagggtgtg      960

ggccatgttt gaggattgcc ccagcattca gttctatgag taataaatat ccacaggctg     1020

ttttcttgga agtcgatgta catcagtgtc agtacttatt cctttgaaga taggaagatg     1080

ttatgttgat gtcattatta cagatgtcat tatggctgca ttagttaaga agagtagcac     1140

attattaatt gcttcaggga acagctgcca ccaacaatat atcagcaaca cctacatttt     1200

tgttttttcg aaacaaagtg agaattgatc aatatcaagg agcagatgct gtgggattag     1260

aagaaaaaat caagcagcac ttagaaaatg accctggaag caatgaggac acagatattc     1320

caaaaggcta tatggattta atgcctttta ttaacaaagc tggttgtgaa tgtcttaatg     1380

aaagtgatga gcatggattt gacaactgtt tacgaaaaga cacaaccttc ttggaatctg     1440

actgtgatga acagctgctt attactgtgg cattcaatca acctgttaag ctttattcca     1500

tgaaatttca agggccagat aatggtcagg gccctaaata tgtaaaaatt tttatcaacc     1560

taccccgatc tatggatttt gaagaggcag aaagaagtga accaactcaa gctctggaac     1620

tgacagagga tgatattaaa gaagatggca ttgttccact tcgttatgtt aagtttcaga     1680

atgttaacag tgtaactata tttgttcagt cgaatcaagg tgaagaggaa acaacaagaa     1740

tttcatattt tacttttatt ggtactccag tccaggcaac aaatatgaat gacttcaaac     1800

gagtagttgg caaaaaagga gaaagccact aaggtacaaa agacactgga caaccatatt     1860

gcaatcagat ctacagctcc tggataattg cttgattctc gccagagact gtcaatgttt     1920

cattcattgc cattaccaat aaatcattgc ttttgttcag atggtatcac tagtgtttcc     1980

attgtaatct tgacacatgc aattgtaaat aaaagtcacc acttttgcca agctt          2035


<210> 4309
<211> 912
<212> DNA
<213> Homo sapiens

<400> 4309
aggagcgtag aggcggcggc aaaatggcgg cgcctgagga gcgggatcta acccaggagc       60

agacagagaa gctgctgcag tttcaggatc tcactggcat cgaatctatg gatcagtgtc      120

gccatacctt ggaacagcat aactggaaca tagaggctgc tgtacaggac agattgaatg      180

agcaagaggg cgtacctagt gttttcaacc cacctccatc acgacccctg caggttaata      240

cagctgacca caggatctac agctatgttg tctcaagacc tcaaccaagg gggctgcttg      300

gatggggtta ttacttgata atgcttccat tccggtttac ctattacacg atacttgata      360

tatttaggtt tgctcttcgt tttatacggc ctgaccctcg cagccgggtc actgaccccg      420

ttggggacat tgtttcattt atgcactctt ttgaagagaa atatgggagg gcacaccctg      480

tcttctacca gggaacgtac agccaggcac ttaacgatgc caaaagggag cttcgctttc      540

ttttggttta tcttcatgga gatgatcacc aggactctga tgagttttgt cgcaacacac      600

tctgtgcacc tgaagttatt tcactaataa acactagttc tcattcattc ttgcttttat      660

gaaaaataaa agtgaaaaac ctccatcaac cagctacttg cagcatctcc tgaggacttg      720

cttctcctgc ctctggggaa gagagggaag agaaagcaca gagcagagaa gcagagatgt      780

tccttgaact gcccacaagt tttcaataac ttttatttct gttttgtaat gaccaaagga      840

atgaggctga cataggtata tatatatatt tttttccttt atttgataaa gagccaattc      900

tttaaaccca tg                                                          912


<210> 4310
<211> 1652
<212> DNA
<213> Homo sapiens

<400> 4310
gaatccttcc gcagctgcac gacgcctgtg tgtctggcct ttccttcttc ttctcttccc       60

cggcagcaca gtgtggctgt ttgtctcctt gcccgccaaa gttctgccca gtccaacgac      120

tccacgcagc tcgcccttgg cgaacagttg tctccaaacg tggtgttgcc gtcagtggtc      180

ccaccaagag gaggggaatg gcagattcac tggagtcaac ccccttgcct tcccccgaag      240

atcgtctggc caaactccat ccttctaagg agctcctgga atattatcaa aagaagatgg      300

ctgagtgtga ggcagaaaat gaggacttgc tgaagaaact ggaactctac aaagaagctt      360

gtgaaggaca gcataaactt gaatgtgatt tgcagcagag ggaggaagag attgctgaat      420

tgcagaaagc tctaagtgat atgcaggtct gcctcttcca ggaacgggaa catgttttac      480

gcctctactc agaaaatgac cgactgagaa tcagggagct agaagacaag aaaaagattc      540

agaatctctt ggctcttgtg ggaacagatg ctggagaagt gacctatttt tgtaaggagc      600

ctcctcacaa agtcaccatt ctccaaaaga ctatccaggc tgtaggtgaa tgtgagcaga      660

gtgaatcttc agctttcaaa gcagatccta aaataagcaa aagaagacca tcgagagaga      720

gaaaagaaag ttctgagcat taccaaagag acatacagac actcatccta caggtggaag      780

cactgcaggc tcagctggga gagcagacca aactttctcg agaacaaatt gaagggctca      840

tcgaggacag acggattcac cttgaggaaa tacaagttca gcaccagaga aatcagaaca      900

aaatcaaaga gctaaccaaa aatcttcacc acacccaaga actgctctat gagagcacca      960

aagattttct gcaactcaga tctgaaaacc aaaataaaga gaagtcatgg atgcttgaaa     1020

aagataattt gatgtcaaag attaagcaat atagggtgca gtgtaagaag aaagaagata     1080

aaattggaaa agtgttgccc gttatgcatg agagtcacca tgctcaaagt gaatatatta     1140

agtccctaaa agataagtta gtacaagaga aaaagctgtc caatatgtac caagagcagt     1200

gcatttcctt agaagaagaa cttgcccgaa ttcgtgagga agagggaatg aggagagaga     1260

tcttcaagga tcgcactaac aagatgggga agcgtttaca gataatgaca aaacgctatg     1320

aggcattgga gcgtcgacgt atcctggaag tagaaggctt taagacagat attaaagttc     1380

tccgacagaa actgaaagac ttggagcaaa tgttgtataa ggcaacagtt aatgcccggg     1440

caaaccagga tcttgccctt ctgtgtgagg tccgtgacag caatagacgg gcacataaga     1500

tacaaggaga actgaagaat cttaagtcga aagtgtttgg tctggagaat gaacttagac     1560

tctgttaatg tctacttttg gaaatggccc ccatttagaa gaggtgtgct tcttgaaacc     1620

tgaggacaag gtcatctgct gccagaaaat gt                                   1652


<210> 4311
<211> 548
<212> DNA
<213> Homo sapiens

<400> 4311
acccgaattg ccacgaggct tcctttaggg gagggatcgg gggagggatg ggagcaaggc       60

tagcagagga gggtcggcat cgcctgtggt tccgaagccc gttagtcatc gttgtagcgt      120

tatcaactgt ggagacctca aacttgattc ttcccccacc cctggacaaa aaggaaaagt      180

gttatttctg tgcagtaatt ggccagcacg gacgctccat ttcttctcaa accttcctca      240

ccatcctgca ggactagaga agcatgaggt ttccctgtaa ccagaaaaac gaatgtttat      300

aaattcttct gtgggatcag agggcacgcc tattacaacc agaaaactac aagtataaca      360

gcgaggatgg atgaacaggc tctattaggg ctaaatccaa atgctgattc agactttaga      420

caaagggccc tggcctattt tgagcagtta aaaatttccc cagatgcctg gcaggtgtgt      480

gcagaagctc tagcccagag gacatacagt gatgatcatg tgaagttttt ctgctttcaa      540

gtactgga                                                               548


<210> 4312
<211> 561
<212> DNA
<213> Homo sapiens

<400> 4312
aattcggtga gtgcggtcct tggagtgggt ctacagccag gtttcctaac ccaggtaccg       60

gacctaccgg gattgctgcg atctgtttag agcccgtgca gaaagtgaca ccgcacgtcc      120

ttgcgtttcg tgcccttgcc ccccgccccc tagcctcagc gagacagctg ccgcgggccc      180

tcccgcagca ggcagtttgg agcatgtgaa caccttgagc cttgatgagt tccagtatgt      240

ggtatattat gcagagcatt cagagcaaat actctctctc cgagcgctta atccgaacaa      300

ttgctgccat ccgttccttc ccacatgata atgtagagga cctcatcaga gggggagcag      360

atgtgaactg cactcatggc acactgaagc ccttgcactg tgcctgtatg gtgtcagatg      420

ctgactgtgt ggagttactt ctggaaaaag gagccgaggt gaatgccctg gatgggtata      480

accgaacagc cctccactat gcagcagaga aagatgaggc ttgtgtggag gtcctattgg      540

agtatggtgc aaaccccaat g                                                561


<210> 4313
<211> 3268
<212> DNA
<213> Homo sapiens

<400> 4313
tcagtcggcc tgcgctcctc agcctggcgg ttctacctcc gagggttcgc ccgcccttgg       60

ttttccttac accttagcct ttggctcctt tgaccactcg aagccccaca gcgtgttcca      120

gcggacttca ccagcagacc cagaagtggt gggtgaaaca ctgcctctgt tcctccttga      180

gcctgtcggg agctgctgcc tgccaccacc atgtctgctg caaatcctga gactccaaac      240

tcaaccatct ccagagaggc cagcacccag tcttcatcag ctgcagctag ccaaggctgg      300

gtgttaccag aaggcaaaat cgtgccaaac actgtttttg ttggtggaat tgatgctagg      360

atggatgaaa ctgagattgg aagctgcttt ggtagatacg gttcagtgaa agaagtgaag      420

ataatcacga atcgaactgg tgtgtccaaa ggctatggat ttgtttcgtt tgttaatgac      480

gtggatgtcc agaagatagt aggatcacag atacatttcc atggtaaaaa gctgaagctg      540

ggccctgcaa tcaggaaaca aaagttatgt gctcgtcatg tgcagccacg tcctttggta      600

gttaatcctc ctcctccacc acagtttcag aacgtctggc ggaatccaaa cactgaaacc      660

tacctgcagc cccaaatcac gccgaatcct gtaactcagc acgttcaggc ttactctgct      720

tatccacatt caccaggtca ggtcatcact ggatgtcagt tgcttgtata taattatcag      780

gaatatccta cttatcccga ttcagcattt caggtcacca ctggatatca gttgcctgta      840

tataattatc agccatttcc tgcttatcca agatcaccat ttcaggtcac tgctggatat      900

cagttgcctg tatataatta tcaggcattt cctgcttatc caaattcacc atttcaagtc      960

gccactggat atcagttccc tgtatacaat tatcagccat ttcctgctta tccaagttca     1020

ccatttcagg tcactgctgg atatcagttg cctgtatata attatcaggc atttcctgct     1080

tatccaaatt caccatttca agtcgccact ggatatcagt tccctgtata caattatcag     1140

gcatttcctg cttatccaaa ttcaccagtt caggtcacca ctggatatca gttgcctgta     1200

tacaattatc aggcatttcc tgcttatcca aattcagcag ttcaggtcac cactggatat     1260

cagttccatg tatacaatta ccagatgcca ccgcagtgcc ctgttgggga gcaaaggaga     1320

aatctgtgga ccgaagcata caaatggtgg tatcttgtct gtttaatcca gagaagagac     1380

tgataaattc cgttgttact caagatgact gcttcaaggg taaaagagtg catcgcttta     1440

gaagaagttt ggcagtattt aaatctgttg gatcctctca gctatctagt ttcatgggaa     1500

gttgctggtt ttgaatatta agctaaaagt tttccactat tacagaaatt ctgaattttg     1560

gtaaatcaca ctgaaacttt ctgtataact tgtattatta gactctctag ttttatctta     1620

acactgaaac tgttcttcat tagatgttta tttagaacct ggttctgtgt ttaatatata     1680

gtttaaagta acaaataatc gagactgaaa gaatgttaag atttatctgc aaggattttt     1740

aaaaaattga aacttgcatt ttaagtgttt aaaagcaaat actgactttc aaaaaagttt     1800

ttaaaacctg atttgaaagc taacaatttt gatagtctga acacaagcat ttcacttctc     1860

caagaagtac ctgtgaacag tacaatattt cagtattgag ctttgcattt atgatttatc     1920

tagaaattta cctcaaaagc agaattttta aaactgcatt tttaatcagt ggaactcaat     1980

gtatagttag ctttattgaa gtcttatcca aacccagtaa aacagattct aagcaaacag     2040

tccaatcagt gagtcataat gtttattcaa agtattttat cttttatcta gaatccacat     2100

atgtatgtcc aatttgattg ggatagtagt taggataact aaaattctgg gcctaatttt     2160

ttaaagaatc caagacaaac taaactttac tgggtatata accttctcaa tgagttacca     2220

ttctttttta taaaaaaaat tgttccttga aatgctaaac ttaatggctg tatgtgaaat     2280

ttgcaaaata ctggtattaa agaacgctgc agctttttta tgtcactcaa aggttaatcg     2340

gagtatctga aaggaattgt ttttataaaa acattgaagt attagttact tgctataaat     2400

agatttttat ttttgttttt tagcctgtta tatttccttc tgtaaaataa aatatgtcca     2460

gaagaggcat gttgtttcta gattaggtag tgtcctcatt ttatattgtg accacacagc     2520

tagagcacca gagccctttt gctatactca cagtcttgtt ttcccagcct cttttactag     2580

tctttcagga ggtttgctct tagaactggt gatgtaaaga atggaagtag ctgtatgagc     2640

agttcaaagg ccaagccgtg gaatggtagc aatgggatat aatacctttc taagggaaac     2700

atttgtatca gtatcatttg atctgccatg gacatgtgtt taaagtggct ttctggccct     2760

tctttcaatg gcttcttccc taaaacgtgg agactctaag ttaatgtcgt tactatgggc     2820

catattacta atgcccactg gggtctatga tttctcaaaa ttttcattcg gaatccgaag     2880

gatacagtct ttaaacttta gaattcccaa gaaggcttta ttacacctca gaaattgaaa     2940

gcaccatgac tttgtccatt aaaaaattat ccatagtttt tttagtgctt ttaacattcc     3000

gacatacatc attctgtgat taaatctcca gatttctgta aatgatacct acattctaaa     3060

gagttaattc taattattcc gatatgacct taaggaaaag taaaggaata aatttttgtc     3120

tttgttgaag tatttaatag agtaaggtaa agaagatatt aagtcccttt caaaatggaa     3180

aattaattct aaactgagaa aaatgttcct actacctatt gctgatactg tctttgcata     3240

aatgaataaa aataaacttt ttttcttc                                        3268


<210> 4314
<211> 2224
<212> DNA
<213> Homo sapiens

<400> 4314
gccgcatctt ccaccctcgc cgccgccgca gctccccgcg ctcgtgccac cgccgccgcg       60

tccaccctca gcgccaccgc catgcgggag atcgtgcacc tgcaggccgg ccagtgcggc      120

aaccagatcg gggccaagtt ttgggaggtt atcagtgacg aacatggcat cgaccccaca      180

ggcacatacc atggggacag tgacctgcaa ctggagagga tcaacgtgta ctacaacgag      240

gccacaggag gaaattatgt ccccagagcg gtgctggtgg acctggaacc cggcaccatg      300

gactctgtcc gttctggccc cttcggtcag atctttcggc cggacaactt cgtgtttggc      360

caatccggag ccggcaacaa ctgggcaaag gggcactaca cggagggcgc agagctggtg      420

gacgctgtcc tggacgtagt ccggaaggag gccgagagct gcgactgcct tcagggcttc      480

cagctgaccc actcgctggg gggtggcacg gggtccggaa tgggcacgct gctcatcagt      540

aagatccgcg aggagttccc agaccgcatc atgaacacct tcagcgtggt gccctcgccc      600

aaagtgtcag acacggtggt ggagccctac aacgccacgc tgtctgtgca ccagctggtg      660

gagaatacgg atgagaccta ctgcatcgac aacgaggcac tctacgacat ctgtttccgc      720

accctcaagc tgaccacccc cacctacggg gacctcaacc acctggtgtc ggccaccatg      780

agcggggtca ccacctgcct gcgcttcccg ggccagctga acgccgacct gcgcaagctg      840

gccgtcaaca tggttccctt tcctcgcctg cacttcttca tgcccggctt cgcacccctg      900

accagccggg gcagccagca gtaccgggcc ctgacggtgc ccgagctcac ccagcagatg      960

ttcgatgcca agaacatgat ggcggcgtgc gacccgcgcc acggccgcta cctgaccgtg     1020

gccgccgtgt tccggggccg catgtccatg aaggaggtgg acgagcagat gctgagcgtg     1080

cagagcaaga acagcagcta cttcgtggag tggatcccca acaacgtgaa gacggccgtg     1140

tgcgacatcc cgccccgcgg cctgaagatg gccgcgacct tcatcggcaa cagcacggcc     1200

atccaggagc tgttcaagcg catctccgag cagttcacgg ccatgttccg gcgcaaggcc     1260

ttcttgcact ggtacacggg cgagggcatg gacgagatgg agttcaccga ggccgagagc     1320

aacatgaatg acctggtatc tgagtaccag cagtaccagg acgccacggc cgaggagggc     1380

gagttcgagg aggaggcgga ggaggaggtg gcctaggctg ctcccatcgc ttcccacctg     1440

tcccctcgag gcttctgacc tttgatccgc taggcccccc atctctgaac cctagagccc     1500

cgctttccct ccaaggctga ctccccgctg accctaacaa tacctttgga gctcgcttta     1560

cctctggcta cttcatctcc gaccctggct cccctttgag ccctaattta tctttaaccc     1620

ccttgagctc ttccaacctt gacattccca ggaggagccc cgcttcaccc cttctgactc     1680

tggaaaccgc acctttaact ttgcagacct tccttcaccc ctgacttctg cttcaccttt     1740

gacctctgcc ccccatgaat cccattttac ctctagacct ataagttctg gtttatgttt     1800

gacccctccc tctgagctgc acttcaccgc tgaccttgcc tcacctttaa ccccccacct     1860

gagccccagc tcctacctct gactccaact tctctttcac cctctatgag tcccatttta     1920

cttctacacc tgcaagtcct ggtttatatt ggacccctcc ctccgagctg cagttcacct     1980

ttgaccttgc ctcacctttc accccccacc ccccacagcg tcagctccta cctctgaccc     2040

cagcttctct ctgattccca caggccccat gcatcctccc tgcctcactc ccctcagccc     2100

ctgccgacct tagcttatct gggagagaaa caaggcctgg tgcctgtgag gaagagaggt     2160

cacccctacc ctccctcccc gcttccctgc ctcaccctca ataaataaat taattgttgt     2220

catg                                                                  2224


<210> 4315
<211> 785
<212> DNA
<213> Homo sapiens

<400> 4315
actataaaga cagtaaaaag atcagtggtt atctttgcag acgccaccat cactgtgagc       60

cctgtactat cagccatggt caactccgtc gtcttttttg acatcaccgt cgacggcaag      120

cccttgggcc gcatctccat caaactgttt gcagacaaga ttctaaagac agcggaaaac      180

tttcgtgctc tgagcactgg agagaaagga tttcgttata agggttcctg ctttcacaga      240

attattccag ggtttatgtg tcagggtggt gacttcacac gccataatgg cactggtgac      300

aagtccatct atggggagaa atttgatgat gagaacctca tccgaaagca tacaggttct      360

ggcatcttgt ccatggcaaa tgctggaccc aacacaaatg gttcccagtt tttcatctgt      420

gctgccaaga ctgagtggtt ggatggcaag catgtggcct ttggcaaggt gaaagaacgt      480

gtgaatattg tggaagccat ggagcacttt gggtacagga atagcaagac cagcaagaag      540

atcaccattg ctgactgtgg acaattctaa tgagtttgac ttgtgtttta ttttcaccac      600

cagacccatt ccttctgtag ctcaggagag cacccctcca ccacatttgc ttgcaatatc      660

ctagaatctt tgtgctcttg ctgcagttcc ctttgggttc catgttttcc ttgttccctt      720

ccatgcctag ctggattgca gagttgagtt aagtttatga ttatgaaata aaaactaagt      780

aacaa                                                                  785


<210> 4316
<211> 3468
<212> DNA
<213> Homo sapiens

<400> 4316
agcacgggct gccgcggcag cagcggcgga gcagcagaga ggccggggag cggcggctgg       60

ctcacgcgcg tcgcgcgggc cgggatgagg gactgtggcg gcgcggcccg cgcgcagccg      120

gccgtgcggc accttcccgt ctgatgctgg cgttgtgcgt atggtgccct gacgtctgtc      180

cacgtgggcg cggaagcaaa cagcgatgtc ccagacgcag gactacgagt gcaggagcca      240

taatgtcgac ctgccggagt cgaggattcc agggtcgaac actcggttgg agtgggtgga      300

gatcatcgaa ccgcgcaccc gcgagcgcat gtacgccaac ctggtcaccg gtgagtgcgt      360

gtgggacccg ccggccggcg tccgcatcaa gcgcaccagc gagaaccagt ggtgggagct      420

gttcgacccc aacacgtccc gcttctacta ctacaatgcc agcacgcagc gcacggtgtg      480

gcaccggccg cagggctgcg acatcatccc gctggccaag ctgcagacgc tgaagcagaa      540

cacggagtcc ccgcgcgcct cggcggagag cagccccggg cgcggcagca gcgtcagccg      600

tgagggcagc accagctcct ccctggagcc cgagcccgac actgagaaag cgcaggagtt      660

gccagcgagg gccgggcggc ccgcggcgtt tgggacagtg aaggaggaca gcggcagctc      720

ttcaccacca ggagtgttcc ttgagaagga ctatgagatt taccgggatt acagtgcgga      780

cggccagctt cttcactaca ggacctcctc gctgcggtgg aactcgggcg ccaaagagcg      840

catgctcatc aaggtcgctg atcgggagcc cagcttcctc gccgcccagg gcaatggcta      900

cgccccagac ggcccacctg gggtccgctc ccgcagaccc tccggcagcc agcactcacc      960

cagcctgcag accttcgccc cggaggctga cggcaccatc ttcttcccag agaggaggcc     1020

gtcacccttc ctgaagaggg ccgagctccc agggagcagc tccccgctgc tggcccagcc     1080

ccgaaagccc tccggggact cgcagccctc ctccccgcgc tatggctatg aacccccgct     1140

ctacgaggag cccccagtgg agtaccaggc ccccatctac gatgagcccc ccatggacgt     1200

gcaattcgag gctggcgggg gctaccaggc cggctctccc cagcggtcgc cgggccgtaa     1260

gccccggccg ttcctccagc ccaacaagca gggccccccc tcgccctgcc agcagctggt     1320

gctcaccaag cagaagtgtc ccgagcgctt cctgagcctg gagtacagtc ccgccggcaa     1380

ggagtacgtg cggcagctgg tctacgtgga gcaggcgggc tccagcccca agctgcgcgc     1440

cggcccgcgg cacaagtacg cgcccaaccc cggcggtggt tcgtactcct tgcagcccag     1500

cccctgcctg ctgagggacc agcgcctggg cgtcaagtcc ggagactaca gcaccatgga     1560

gggacctgag ctgcggcaca gccagccgcc cacgccgctg ccacaggccc aggaggatgc     1620

catgtcctgg tccagccagc aggacaccct gtcctccaca ggctactccc cgggcacgcg     1680

caagcggaag agcagaaagc cctctttgtg ccaagccacc agcgccaccc ccactgaggg     1740

ccccggggac ctgcttgtgg agcagcccct ggccgaggaa cagcccccgt gcgggaccag     1800

cctcgccccc gtgaagcgag cggaaggtga ggccgaaggg gcgcggggcg cggccgagcc     1860

cttcctggcg caggctcggc tggcctggga ggcgcagcag gcccacttcc acatgaagca     1920

gaggagcagc tgggactccc agcaggacgg ctctggctac gagagcgacg gcgccctgcc     1980

actgcccatg cccgggccgg tggtgcgggc cttcagcgag gacgaggcgc tggcccagca     2040

ggagaacagg cactggagga ggggcacctt cgagaagcta ggcttccccc agatcctgct     2100

ggagaagagc gtctccgtgc agaccaacct ggcctcacca gagccctacc tccacccctc     2160

acagtctgag gacctcgctg cctgtgccca gttcgagagc agccggcaga gccgcagcgg     2220

cgttcccagc tccagctgcg tcttccccac tttcacgctg cgcaagccct cctcggagac     2280

ggacatcgag aactgggcct ccaagcactt caacaagcac acgcagggcc tcttccggcg     2340

gaaggtgtcc atcgccaaca tgctggcctg gagcagcgag tccatcaaga agcccatgat     2400

cgtgacaagc gaccggcacg tgaagaagga ggcctgcgag ctcttcaagc tgatccagat     2460

gtacatgggt gaccggcggg ccaaggccga cccactgcac gtggccctgg aggtggccac     2520

caagggctgg agcgtgcagg gcctgcggga cgagctctac atccagctgt gccggcagac     2580

caccgagaac ttccgcctgg agagcctggc ccgcggctgg gagctcatgg ccatctgcct     2640

ggcctttttc ccgcccaccc ccaagttcca ctcctacctg gaaggctaca tctaccggca     2700

catggacccc gtcaatgaca ctaaaggggt ggcgataagc acgtatgcca agtactgtta     2760

ccacaagcta cagaaggcag ccctgaccgg ggccaagaag gggctgaaga agcccaacgt     2820

ggaggagatc cggcatgcca agaacgccgt gttcagcccg tccatgttcg gcagcgcact     2880

gcaggaggtc atgggcatgc agagagagcg ctaccccgag cgccagctgc cctgggtgca     2940

gacacggctc tctgaggagg tgctggcgct caacggtgac cagacagagg gcatcttcag     3000

ggtccctggg gacattgacg aggtgaatgc cctgaagctg caggtggacc agtggaaggt     3060

gcccacaggc ctggaagacc cccacgtccc tgcgtccctg ctgaagctgt ggtaccggga     3120

gctggaggag cccctgatcc cgcacgagtt ctacgagcag tgcatcgcgc actacgacag     3180

ccccgaggcg gcggtggccg tggtgcacgc gctgccccgc atcaaccgca tggtgctgtg     3240

ctacctcatc cgcttcctgc aggtcttcgt gcagccggcc aacgtcgcgg tcaccaagat     3300

ggatgtcagc aacctggcca tggtgatggc gcccaactgc ttgcgctgcc agtccgacga     3360

cccgcgcgtc atcttcgaga acacccgcaa ggagatgtcc ttcctgcggg tgctcatcca     3420

gcacctggac accagcttca tggagggtgt gctgtagcgg gggcgccc                  3468


<210> 4317
<211> 1894
<212> DNA
<213> Homo sapiens

<400> 4317
ggatagttcc tcccggccac gccgcgccgg ctctgggcac tcagcatcgt ttccttttcc       60

tccgctggag cagctatggc ggcggtgaag accctgaacc ccaagggcac catgaagatg      120

ctcgtttctg gcgctggaga catcaaactt actaaagacg gcaatgtgct gcttcacgaa      180

atgcaaattc aacacccaac agcttcctta atagcaaagg tagcaacagc ccaggatgat      240

ataactggtg atggtacgac ttctaatgtc ctaatcattg gagagctgct gaaacaggcg      300

gatctctaca tttctgaagg ccttcatcct agaataatca ctgaaggatt tgaagctgca      360

aaggaaaagg cccttcagtt tttggaagaa gtcaaagtaa gcagagagat ggacagggaa      420

acacttatag atgtggccag aacatctctt cgtactaaag ttcatgctga acttgcagat      480

gtcttaacag aggctgtagt ggactccatt ttggccatta aaaagcaaga tgaacctatt      540

gatctcttca tgattgagat catggagatg aaacataaat ctgaaactga tacaagctta      600

atcagagggc ttgttttgga ccacggagca cggcatcctg atatgaagaa aagggtggag      660

gatgcataca tcctcacttg taacgtgtca ttagagtatg agaaaacaga agtgaattct      720

ggcttttttt acaagagtgc agaagagaga gaaaaactcg tgaaagctga aagaaaattc      780

attgaagata gggttaaaaa aataatagaa ctgaaaagga aagtctgtgg cgattcagat      840

aaaggatttg ttgttattaa tcaaaaggga attgacccct tttccttaga tgctctttca      900

aaagaaggca tagttgctct gcgcagagct aaaaggagaa atatggagag gctgactctt      960

gcttgtggtg gggtagccct gaattctttt gacgacctaa gtcctgactg cttgggacat     1020

gcaggacttg tatatgagta tacattggga gaagagaagt ttacctttat tgagaaatgt     1080

aacaaccctc gttctgtcac attattgatc aaaggaccaa ataagcacac actcactcag     1140

atcaaagatg cagtgaggga cggcttgagg gctgtcaaaa atgctattga tgatggctgt     1200

gtggttccag gtgctggtgc cgtggaagtg gcaatggcag aagccctgat taaacataag     1260

cccagtgtaa agggcagggc acagcttgga gtccaagcat ttgctgatgc attgctcatt     1320

attcccaagg ttcttgctca gaactctggt tttgaccttc aggaaacatt agttaaaatt     1380

caagcagaac attcagaatc aggtcagctt gtgggtgtgg acctgaacac aggtgagcca     1440

atggtggcag cagaagtagg cgtatgggat aactattgtg taaagaaaca gcttcttcac     1500

tcctgcactg tgattgccac caacattctc ttggttgatg agatcatgcg agctggaatg     1560

tcttctctga aaggttgaat tgaagcttcc tctgtatctg aatcttgaag actgcaaagt     1620

gatcctgagg attacagctg tggaattttt gtccaagctt caaataattt tgaaagaaat     1680

tttcccatat gaaaaaagga gagaacactg gcatctgttg aaatttggaa gttctgaaat     1740

tatagtattt ttaaaaattg cactgaagtg tatacacata aagcaggtct tttatccagt     1800

gaacaggatg ttttgcttta gcagcagtga cataaaattc catgttagat aagcatatgt     1860

tacttacctt gttattaaat atttcttgaa aagc                                 1894


<210> 4318
<211> 2315
<212> DNA
<213> Homo sapiens

<400> 4318
tgggctcctt cctcatcaaa ccagtacaga gagtaatgcg ttacccgctg ttgctaatgg       60

agttgctgaa ttccacccca gaatcccacc cagataaagt gcctttaacc aatgcagtcc      120

ttgcggtcaa ggaaatcaac gttaacatta atgaatataa acggcgaaag gacctggata      180

aaagatgaag tatttgaaga aacagaaaaa aacttccgaa tgcaagaaag attgattaag      240

tcttttatcc gagacctgtc tctctacctc cagcacatcc ggttcatttt atcaaaacca      300

gtttgaaaat caaatattga atgcaaaagc taggaagctg taaacaggaa acgtaaacga      360

gaaagaacaa gcagtgaata cgagagtccg catgtgtgaa agtggtggct gctgtgagca      420

tgtgggatgt gtgcatggag agaggacacc gggacctgga gcagtttgag agggtgcatc      480

gctacatcag tgaccagctc ttcacaaact ttaaggagag gacagagcgg cttgtcatct      540

cccccttaaa tcagttactg agcatgttta cagggcccca taagctggta cagaaacgct      600

ttgacaagct cctggacttc tataactgta cagaacgggc agaaaagcta aaggacaaga      660

agaccctgga ggagctgcag tcggcccgga acaactatga ggccctgaat gcacagctgc      720

tggatgagct gcccaagttc caccagtacg cccagggcct cttcaccaac tgtgtccacg      780

gctatgctga agcccactgt gactttgtgc accaggctct ggagcaatta aagccactgc      840

tttcgttact caaagtggct ggcagagagg gaaaccttat tgccatcttc cacgaagagc      900

acagcagagt tctgcagcaa ctccaggttt ttaccttctt cccggagtct cttccagcta      960

ccaagaagcc atttgagagg aaaaccattg accgccagtc tgctcgaaag ccactcctgg     1020

gcctgccaag ttacatgcta cagtcagaag aactccgggc ctccctcctg gccaggtatc     1080

cccctgaaaa actcttccag gcagaacgga acttcaatgc tgctcaagac ttggatgtct     1140

cacttttgga aggtgacctg gtgggtgtga ttaagaaaaa agaccccatg ggcagccaga     1200

accgctggct gattgacaat ggagtcacca aaggcttcgt gtacagctct ttcctaaagc     1260

cctacaatcc tcgccgcagc cactccgatg cctccgtggg tagccactcc tccacagagt     1320

ctgagcacgg cagctcctcc cccaggttcc cacgccagaa cagcggcagc accctgacct     1380

tcaaccccag cagcatggct gtatccttta cctcggggtc ttgccagaag cagcctcaag     1440

atgcatctcc tccgccaaaa gaatgtgacc aaggaactct cagtgcatcc ctaaatccga     1500

gtaattcaga gagtagtcct tccagatgcc cttcagaccc agactccacc tcccagccaa     1560

ggtcagggga ctctgcagat gtagctagag atgtaaagca acccactgcc acgccgagga     1620

gctaccggaa cttcaggcat ccagaaatag ttggctactc cgtaccagga cgaaatgggc     1680

aaagtcaaga cctcgtcaaa ggatgtgcaa gaacagccca ggctccggaa gacagaagta     1740

cagagccaga tggcagtgag gcagaaggca accaggtcta ttttgctgtc tacaccttca     1800

aggcacgaaa cccaaatgag ctgagcgtgt cagccaatca gaaactcaag atcctcgagt     1860

ttaaagatgt tacaggaaat acagagtggt ggttagctga ggttaacggg aagaagggct     1920

acgttccctc caattatatc cgcaaaaccg agtacacctg agcccacgtt gcctgccacc     1980

cagccttgct gcctttgctt tcagtccgcc gagggttctg gcggcccacc gagagggcgc     2040

ctgctcctga gacacaggcc ctgtctgcgt tgcttaacca tggcatggtg gagcacacca     2100

cagatcttgt tctcctcgat tgggttgtaa accttgatgc tcactagaat ctctagaatt     2160

tgaaatggac cctggggctt tgcaaatgac ttagtgacta tgagaagaga gacaagtctt     2220

agagctggct tttggaaagg agaaacttgc agtcagaagc ccagtgtcct atgtatgcag     2280

gaagctgtgc tctagcaata gacagtgttg gtaat                                2315


<210> 4319
<211> 1042
<212> DNA
<213> Homo sapiens

<400> 4319
attccgcgct tggcaacggc tcggcgtcgc gctttggcca accgctgcgt cgtccctggg       60

cccgaataac tgtcgcccgc ttccctcagc gtgaggtaca aatgatgcaa aatgtgcacc      120

tggctccaga gacagatgaa gatgatcttt attccggcta taatgactac aatccaatct      180

atgatatcga ggaattggag aatgatgcag cttttcagca agctgtgagg actagtcatg      240

gcagaagacc tccaataact gctaaaatat caagcacggc agttactaga cctatagcta      300

ctggatatgg gtccaagaca tctctggcat catcaatagg aagaccaatg acaggggcta      360

ttcaggatgg agttactaga cccatgacag cagtgagagc agctggtttt accaaagcag      420

ctttgagagc ccagaggaaa aaataaagca attagagaag gaagtaaatg agttggtaga      480

agaaagctgt attgccaata gttgtggaga cttaaaattg gccttagaaa aggcaaaaga      540

tgcaggaaga aaagagagag tcctggtgag acagcgagaa caagttacaa ctccagaaaa      600

tatcaatttg gatttaactt actcagttct tttcaatttg gccagtcagt attcagttaa      660

tgaaatgtat gccgaagcac ttaacactta tcaagttata gtcaaaaata agatgtttag      720

caatgcagga ttaaaataat gcagaatatt ggagttacat ttattcaggc tggtcagtat      780

tcagatgcta ttaattcata tgagcacata atgagcatgg caccaaatct gaaggcaggc      840

tacaacctaa ctatctgtta ttttgctatt ggagaccgag aaaaaatgaa gaaggcattc      900

caaaaattga ttactgttcc attagaaatt gatgaagata aatatatttc accaagtgat      960

gatcctcata ctaacttagt aactgaagct ataaaaaatg atcacctcag gcaaatggaa     1020

cgtgaaagga aagccatggc ag                                              1042


<210> 4320
<211> 4400
<212> DNA
<213> Homo sapiens

<400> 4320
tggcaacagg caaaggagaa acagctctga catacaaaga aaatgagtat gctaaagcca       60

agtgggctta aggcccccac caagatcctg aagcctggaa gcacagctct gaagacacct      120

acggctgttg tagctccagt agaaaaaacc atatccagtg aaaaagcatc aagcactcca      180

tcatctgaga ctcaggagga atttgtggat gactttcgag ttggggagcg agtttgggtg      240

aatggaaata agcctggatt tatccagttt cttggagaaa cccagtttgc accaggccag      300

tgggctggaa ttgttttaga tgaacccata ggcaagaacg atggttcggt ggcaggagtt      360

cggtatttcc agtgtgaacc tttaaagggc atatttaccc gaccttcaaa gttaacaagg      420

aaggtgcaag cagaagatga agctaatggc ctgcagacaa cgcccgcctc ccgagctact      480

tcaccgctgt gcacttctac ggccagcatg gtgtcttcct ccccctccac cccttcaaac      540

atccctcaga aaccatcaca gccagcagca aaggaacctt cagctacgcc tccgatcagc      600

aaccttacaa aaactgccag tgaatctatc tccaaccttt cagaggctgg ctcaatcaag      660

aaaggagaaa gagagctcaa aatcggagac agagtattgg ttggtggcac taaggctggt      720

gtagtccggt ttcttgggga gaccgacttt gccaaggggg agtggtgtgg cgtggagtta      780

gatgagccac ttgggaagaa tgatggcgct gttgctggaa caaggtattt tcagtgtcaa      840

cccaaatatg gcttgttcgc tcctgtccac aaagttacca agattggctt cccttccact      900

acaccagcca aagccaaggc caacgcagtg aggcgagtga tggcgaccac gtccgccagc      960

ctgaagcgca gcccttctgc ctcttccctc agctccatga gctcagtggc ctcctctgtg     1020

agcagcaggc ccagtcggac aggactattg actgaaacct cctcccgtta cgccaggaag     1080

atctccggta ccactgccct ccaggaggcc ctgaaggaga agcagcagca cattgagcag     1140

ctgctggcgg aacgggatct ggagagggcg gaggtggcca aggccacgag ccacgtgggg     1200

gagatagagc aggagctagc tctggcccgg gacggacatg accagcatgt cctggaattg     1260

gaagccaaaa tggaccagct gcgaacaatg gtggaagctg ctgacaggga gaaggtggag     1320

cttctcaacc agcttgaaga ggagaaaagg aaggttgagg accttcagtt ccgggttgaa     1380

gaagaatcaa ttaccaaagg tgatcttgag caaaagagcc agatttctga agatcctgag     1440

aatacgcaga ccaaactgga gcatgcccgc attaaggagc ttgaacagag cctgctcttt     1500

gaaaagacca aagctgacaa actccagagg gagttagaag acactagggt ggctacagtt     1560

tcagaaaagt cacgtataat ggaactggag aaagacctag cattgagagt acaggaagta     1620

gctgagctcc gaagaaggct agagtccaat aagcctgctg gggatgtgga catgtcactt     1680

tcccttttgc aagagataag ctctttgcaa gaaaagttag aagtcacccg tactgaccac     1740

cagagagaaa taacttctct gaaggagcat tttggagccc gggaagaaac tcatcagaag     1800

gagataaagg ctctgtatac cgccacggaa aagctttcca aagagaacga gtcattgaaa     1860

agcaagctgg agcatgccaa caaagagaac tcagatgtga tagctctatg gaagtccaaa     1920

ctggagactg ccatcgcatc ccaccagcag gcgatggaag aactgaaggt atctttcagc     1980

aaagggcttg gaacagagac ggcagaattt gctgaactaa aaacacaaat agagaaaatg     2040

agactagatt accaacacga aatagaaaat ttgcagaatc aacaagactc tgaacgggct     2100

gcccatgcta aagagatgga agccttgagg gctaaactga tgaaagttat taaagaaaag     2160

gaaaacagtc tggaagccat caggtcgaaa ctggacaaag cagaagacca gcatctcgta     2220

gaaatggaag acacgttaaa caaattacag gaagctgaaa taaaggtaaa ggagctagag     2280

gtactgcaag ccaaatgcaa tgaacaaacc aaggttattg ataattttac atcacagctc     2340

aaggctactg aagaaaagct cttggatctt gatgcacttc ggaaagccag ttccgaaggt     2400

aaatcggaaa tgaagaaact tagacagcag cttgaggcag ctgagaaaca gattaaacat     2460

ttagagattg aaaagaatgc tgaaagtagc aaggctagta gcattaccag agagctccag     2520

gggagagagc taaagcttac taaccttcag gaaaatttga gtgaagtcag tcaagtgaaa     2580

gagactttgg aaaaagaact tcagattttg aaagaaaagt ttgctgaagc ttcagaggag     2640

gcagtctctg ttcagagaag tatgcaagaa actgtaaata agttacacca aaaggaggaa     2700

cagtttaaca tgctgtcttc tgacttggag aagctgagag aaaacttagc agatatggag     2760

gcaaaattta gagagaaaga tgagagagaa gagcagctga taaaggcaaa ggaaaaactg     2820

gaaaatgaca ttgcagaaat aatgaagatg tcaggagata actcttctca gctgacaaaa     2880

atgaacgatg aattacgtct gaaagaaaga gatgtagaag aattacagct aaaacttaca     2940

aaggctaatg aaaatgcaag ttttctgcaa aaaagtattg aggacatgac tgtcaaagct     3000

gaacagagcc agcaagaagc agctaaaaag catgaggaag aaaagaaaga attggagagg     3060

aaattgtcgg acctggaaaa gaaaatggaa acaagccaca accagtgtca ggagctgaaa     3120

gccaggtatg agagagccac ttctgagaca aaaaccaagc atgaagaaat cctacagaac     3180

ctccagaaga cgctgctgga cacagaggac aagctgaagg gcgcacggga ggagaacagt     3240

ggcttgctgc aggagctgga ggagctgaga aagcaagccg acaaagccaa agctgctcaa     3300

acagcggaag atgccatgca gataatggaa cagatgacca aagagaagac tgagactctg     3360

gcctccttgg aggacaccaa gcaaacaaat gcaaaactac agaatgaatt ggacacactt     3420

aaagaaaaca acttgaaaaa tgtggaagag ctgaacaaat caaaagaact cctgactgta     3480

gagaatcaaa aaatggaaga atttaggaaa gaaatagaaa ccctaaagca ggcagcagct     3540

cagaagtccc agcagctttc agcgttgcaa gaagagaacg ttaaacttgc tgaggagctg     3600

gggagaagca gggacgaagt cacaagtcat caaaagctgg aagaagaaag atctgtgctc     3660

aataatcagt tgttagaaat gaaaaaaaga gaatccaagt tcataaaaga cgcagatgaa     3720

gagaaagctt ccttgcagaa atccatcagt ataactagtg ccttactcac agaaaaggat     3780

gccgagctgg agaaactgag aaatgaggtc acagtgctca ggggagaaaa cgcctctgcc     3840

aagtccttgc attcagttgt tcagactcta gagtctgata aggtgaagct cgagctcaag     3900

gtaaagaact tggagcttca actcaaagaa aacaagaggc agctcagcag ctcctcaggt     3960

aatacagaca ctcaggcaga cgaggatgaa agagcccagg agagtcagat tgatttccta     4020

aattcagtaa tagtggacct tcaaaggaag aatcaagacc tcaagatgaa ggtggagatg     4080

atgtcagaag cagccctgaa tgggaacggg gatgacctaa acaattatga cagtgatgat     4140

caggagaaac agtccaagaa gaaacctcgc ctcttctgtg acatttgtga ctgctttgat     4200

ctccacgaca cagaggattg tcctacccag gcacagatgt cagaggaccc tccccattcc     4260

acacaccatg gcagtcgggg tgaggaacgc ccatactgtg aaatctgtga gatgtttgga     4320

cactgggcca ccaactgcaa tgacgacgaa accttctgat gaagcctcca gtggagaact     4380

gggcttgctc agacgcactc                                                 4400


<210> 4321
<211> 636
<212> DNA
<213> Homo sapiens

<400> 4321
atggcctttg cagactctca tttatggaaa ctcctggatc ggcatgcaaa tacaatcaga       60

ttatttgttt tgctacctga acaatcccca gtatcttatt ccaaaaggac agcataccag      120

aaagctggag gcgattctgg taatgtggat gatgactgtg aaagagtcaa aggacctgta      180

ggaagcctaa agtctgtgga agctattcta gaagaaagca ctgaaaaact caaaagcttg      240

tcactgcagc aacagcagga tggagataat ggggacagca gcaaaagtac tgagacaagt      300

gactttgaaa acatcgaatc acctctcaat gagagggact cttcagcatc agtggataat      360

agagaacttg aacagcatat tcagacttct gatccagaaa attttcagtc tgaagaacga      420

tcagactcag atgtgaataa tgacaggagt acaagttcag tggacagtga tattcttagc      480

tccagtcata gcagtgatac tttgtgcaat gcagacaatg ctcagatccc tttggctaat      540

ggacttgact ctcacagtat cacaagtagt agaagaacga aagcaaatag ggaaaaaaga      600

aacatgggat acagcagaag aagactctgg aactga                                636


<210> 4322
<211> 2280
<212> DNA
<213> Homo sapiens

<400> 4322
actgaccccg ctgtaccacg gccctcttgc ggacagcccc ggggacgtcg ttgggacatc       60

gctgggaccc cgggctctgc agccacaacc atgtttggcc ggaagcgcag tgtctccttt      120

gggggcttcg gatggatcga caagaccatg ctggcaagtc tgaaggtcaa gaagcaggag      180

ctggccaaca gctcggatgc gaccctccca gaccggccgc tctcccctcc tctcacggca      240

cctcccacca tgaagtcgtc ggagttcttt gagatgctgg agaaaatgca ggggatcaag      300

cttgaagagc agaagccggg accccagaag aacaaggacg actatatccc ataccccagc      360

atcgacgagg ttgtggagaa gggaggcccg taccctcagg tcatcctgcc acagtttggg      420

ggctattgga tcgaggaccc ggagaacgtg ggcaccccaa catcgctggg gagcagcatc      480

tgtgaggagg aggaagagga caacctcagc cccaacacat ttggctacaa gctcgagtgc      540

aagggtgaag ccagggccta ccggaggcac ttcctgggga aggatcatct aaacttttac      600

tgtaccggca gcagcctggg gaacttgatc ctgtccgtca agtgcgagga agcagagggg      660

atcgagtacc tccgggtcat ccttaggtcc aaactgaaga cggtacatga gcggatcccc      720

ttggctggac tgagcaagct tcccagtgtc cctcagattg caaaggcttt ctgtgatgat      780

gcagtgggac tgagattcaa tcctgtcctg taccccaagg cctcccaaat gattgtgtcc      840

tatgatgagc atgaagtcaa caacacattc aaattcggag tcatttatca aaaagccagg      900

cagaccctgg aggaggagct atttgggaac aatgaggaga gcccagcttt taaggagttc      960

ttggacctgc tgggggacac gatcacactg caggatttca aaggtttccg aggaggcctg     1020

gacgtgaccc acggacagac aggggtggaa tcagtgtaca caacattccg ggacagggag     1080

atcatgtttc acgtttccac aaagctgcca tttaccgacg gagacgccca gcagctccag     1140

agaaagagac acattggaaa tgacatcgtg gccatcatct tccaagagga aaacacgccg     1200

tttgtcccag acatgatagc ctccaatttc ttacatgcct acatcgtcgt gcaggtcgag     1260

accccaggca cagagacccc atcctacaag gtctctgtca ctgcgcggga agatgtgccc     1320

acctttggtc cacctctgcc cagtcccccc gttttccaga agggcccgga attcagggag     1380

tttctgctca ccaagctcac caatgccgag aacgcctgct gcaagtcgga caagtttgca     1440

aagctggagg accggaccag ggctgccctc ctggacaacc ttcacgatga gctccacgcc     1500

cacacacagg ccatgctggg actgggccca gaggaggaca agtttgagaa tggaggccac     1560

ggggggttcc tggagtcttt taagagggcc atccgcgtac gcagccactc catggagacc     1620

atggtgggcg gccagaagaa gtcgcacagt gggggcatcc ctggcagcct cagcgggggc     1680

atctcccaca acagcatgga ggtcaccaag accaccttct cgcctccagt ggtggcggca     1740

acggtgaaga accagtcacg gagtcccatc aagcgacgct cggggctctt cccccgcctg     1800

cacacgggct cagaaggcca gggcgacagc cgggcacgat gtgacagcac atccagcaca     1860

cccaagaccc cagatggtgg acactcctct caggagataa agtctgagac ctcatccaat     1920

cccagctctc cggaaatctg ccccaacaag gagaagccct tcatgaagtt gaaggaaaac     1980

ggccgtgcca tctcccgctc ctcctccagc accagcagcg tcagcagcac tgcaggggag     2040

ggcgaggcca tggaggaggg cgacagtggg ggcagccagc cgtccacgac ctcacccttc     2100

aagcaggagg tgtttgtcta cagcccgtcc ccgagcagcg agagccccag cctgggggca     2160

gctgccaccc cgatcatcat gagccggagt cccacagatg ccaaaagcag aaactccccg     2220

agatcgaacc tgaaattccg ctttgacaag ctcagccatg ccagctctgg tgcggggcac     2280


<210> 4323
<211> 1644
<212> DNA
<213> Homo sapiens

<400> 4323
gtgaggcgga agctgtgtat ggcgggaggc tgtggcggtc ccttggtggg gaagctgttg       60

ctgttgctag acgacgggaa ctagctctcg tcacttcctc agcccgccgt ctgcccactc      120

ctctagccgg aacctggggg cccggagccg gggtaggcac agagttgtcc tcggaggtcc      180

aggacagcgg ccagcccggc ggcgggagtc agggccacgc cacctgcagg gaagaacccg      240

agtcgaagcg ggaagatggc tgcagacaag cctgcagatc agggagcaga gaaacatgaa      300

ggcacaggtc agtcctctgg gatcactgat caagagaagg agttatccac caatgctttc      360

caagctttca catctggaaa ttatgatgcc tgtctacaac accttgcctg tctacaagat      420

ataaacaaag atgattataa aataattttg aatacagcag tagctgagtt ttttaaaagt      480

aaccaaacaa caacagataa tttgagacaa acacttaacc agctgaagaa tcaggtccac      540

tcagctgttg aagaaatgga tggattagat gatgttgaaa acagcatgtt gtactataat      600

caagcagtca ttctttatca tctgcggcag tatacagaag ccatatcagt tggtgaaaaa      660

ctttatcagt tcatagagcc ttttgaagaa aaatttgccc aagcagtgtg ttttttgctt      720

gtagacctgt atatattaac ctaccaagct gagaaagctt tgcatcttct tgctgtccta      780

gaaaaaatga tttcacaggg taacaataac aaaaatggaa agaatgagac tggtaataac      840

aacaacaaag atggatctaa tcataaagct gaaagtggag ctctaataga agctgcaaaa      900

tcaaagatac atcagtacaa agtacgagct tatatccaaa tgaagtctct gaaagcatgt      960

aaaagggaaa tcaagtcagt catgaataca gctggaaatt ccgcaccctc tctctttctt     1020

aaaagcaatt ttgagtactt aagaggtaat tatcgaaaag ccgtgaagct attaaatagt     1080

tcaaacattg ctgagcatcc aggattcatg aaaacaggtg aatgcttgag atgcatgttc     1140

tggaataacc ttggttgcat ccattttgcc atgagcaagc acaatttggg aatattctac     1200

tttaaaaagg ctctgcaaga gaatgacaat gtctgtgcac agctcagtgc aggtagcact     1260

gatccaggta aaaaattttc aggaagaccc atgtgtacgt tactaaccaa taagagatat     1320

gagttgctgt ataactgtgg aattcagctt cttcacattg gaaggcctct tgctgccttc     1380

gaatgtctga ttgaagctgt tcaggtttat catgcaaatc ctcgcctctg gctacggctg     1440

gctgaatgct gcattgctgc caataagggg acttctgaac aagaaactaa aggccttccc     1500

agcaaaaaag gaattgtaca gtctattgtt ggtcaaggct atcatcgtaa aatagttttg     1560

gcatcacagt ctatacagaa tactgtttat aatgatgggc agtcttcggc cattcctgta     1620

gccaaagcag gaaaatgggg ctaa                                            1644


<210> 4324
<211> 2530
<212> DNA
<213> Homo sapiens

<400> 4324
gatgcctgag atcagagtca cgcccttggg tgcctgccct gtgctgtcct ggaacctggt       60

ccttccaccg ggcagggggt cgagggcacc ttccagcaca gacaccagga cgggattcca      120

tgtcctcccc catggcgtga gcgcttcctc ggagggtgcc ccccgccccg gtgtggacac      180

tgtgctgtga acacccctgg cctgtgcaca ccccatggca ttttgcagct gtttgcatgg      240

gccccactgc cctcccctgc tctctgggtc ctccgtgggg tcctcccagc ctgccccttt      300

cccatttggc ctcttggctg cctgttctgc ccactctctg gacatctgat ctttctgatc      360

tttcatgtgg cttcaattac ccgcaatctg tacctgggta tattctcaag gtcacctcag      420

ccaaggcagc ccctcggctg tggccccgtc atcctgatgt gtggtgctgg ctttggacac      480

ttcgagtggc tggcaggggg aggggccggc caggacgtgg gccgaagctg catcctggtc      540

tccattgcgg gcaagaatgt catgctggac tgtggaatgc acatgggctt caatgacgac      600

cgacgcttcc ctgacttctc ctacatcacc cagaacggcc gcctaacaga cttcctggac      660

tgtgtgatca ttagccactt ccacctggac cactgcgggg cactccccta cttcagcgag      720

atggtgggct acgacgggcc catctacatg actcacccca cccaggccat ctgccccatc      780

ttgctggagg actaccgcaa gatcgccgta gacaagaagg gcgaggccaa cttcttcacc      840

tcccagatga tcaaagactg catgaagaag gtggtggctg tccacctcca ccagacggtc      900

caggtagatg atgagctgga gatcaaggcc tactatgcag gccacgtgct gggggcagcc      960

atgttccaga ttaaagtggg ctcagagtct gtggtctaca cgggtgatta taacatgacc     1020

ccagaccgac acttaggagc tgcctggatt gacaagtgcc gccccaacct gctcatcaca     1080

gagtccacgt acgccacgac catccgtgac tccaagcgct gccgggagcg agacttcctg     1140

aagaaagtcc acgagaccgt ggagcgtggt gggaaggtgc tgatacctgt gttcgcgctg     1200

ggccgcgccc aggagctctg catcctcctg gagaccttct gggagcgcat gaacctgaag     1260

gtgcccatct acttctccac ggggctgacc gagaaggcca accactacta caagctgttc     1320

atcccctgga ccaaccagaa gatccgcaag actttcgtgc agaggaacat gtttgagttc     1380

aagcacatca aggccttcga ccgggctttt gctgacaacc caggaccgat ggttgtgttt     1440

gccacgccag gaatgctgca cgctgggcag tccctgcaga tcttccggaa atgggccgga     1500

aacgaaaaga acatggtcat catgcccggc tactgcgtgc agggcaccgt cggccacaag     1560

atcctcagcg ggcagcggaa gctcgagatg gaggggcggc aggtgctgga ggtcaagatg     1620

caggtggagt acatgtcatt cagcgcacac gcggacgcca agggcatcat gcagctggtg     1680

ggccaggcag agccggagag cgtgctgctg gtgcatggcg aggccaagaa gatggagttc     1740

ctgaagcaga agatcgagca ggagctccgg gtcaactgct acatgccggc caatggcgag     1800

acggtgacgc tgcccacaag ccccagcatc cccgtaggca tctcgctggg gctgctgaag     1860

cgggagatgg cgcaggggct gctccctgag gccaagaagc ctcggctcct gcacggcacc     1920

ctgatcatga aggacagcaa cttccggctg gtgtcctcag agcaagccct caaagagctg     1980

ggtctggctg agcaccagct gcgcttcacc tgccgcgtgc acctgcatga cacacgcaag     2040

gagcaggaga cggcattgcg cgtctacagc cacctcaaga gcgtcctgaa ggaccactgt     2100

gtgcagcacc tcccagacgg ctctgtgact gtggagtccg tcctcctcca ggccgccgcc     2160

ccttctgagg acccaggcac caaggtgctg ctggtctcct ggacctacca ggacgaggag     2220

ctggggagct tcctcacatc tctgctgaag aagggcctcc cccaggcccc cagctgaggc     2280

cggcaactca cccagccgcc acctctgccc tctcccagct ggacagaccc tgggcctgca     2340

cttcaggact gtgggtgccc tgggtgaaca gaccctgcag gtcccatccc tggggacaga     2400

ggccttgtgt cacctgcctg cccaggcagc tgtttgcagc tgaagaaaca aactggtctc     2460

caggctgtct tgcctttatt cctggttagg gcaggtggtc ctagacagca gtttccagta     2520

aaagctgaac                                                            2530


<210> 4325
<211> 932
<212> DNA
<213> Homo sapiens

<400> 4325
gcttccggca ccggccgagg tgcgggtcgc ctccagagat cctgtgcctt caaaccctac       60

gagtccatac tttaaaacaa aatgaagaaa gtaaggctta aggaactaga gagtcgcctg      120

caacaagtgg atggatttga aaagcccaag ctacttctgg aacagtatcc taccaggccg      180

cacattgcag catgtatgct ctatacaatc cataacactt atgatgacat tgaaaataaa      240

gtcgttgcag atctaggatg tggttgtgga gtacttagca tcggaactgc aatgttagga      300

gcagggttgt gtgttggatt tgacatagat gaagacgcat tggaaatatt taataggaat      360

gcagaagagt ttgagttaca aatattgaca tggttcaatg tgatgtgtgc ttattatcta      420

acagaatgtc caagtcattc gatacagaat tatgaatcct ccctttggga ccaaaaataa      480

taaagggaca gatatggctt ttctaaagac tgctttggaa atggcaagaa cagcagtata      540

ttccttacac aaatcctcaa ctagagaaca tgttcaaaag aaagctgcag aatggaaaat      600

caagatagat attatagcag aacttcgata tgacctgcca gcatcataca agtttcacaa      660

aaagaaatca gtctgatcat ctaaatcacc cgaaaatttc agcaagcatc caatcttttc      720

ttctagagat ttctataaaa atatacaaag tgatcaaaaa gtttcttaaa agcaacaaca      780

gaccagaaat gactcacacc accttatagc tatacaagaa aaagactaga aaccaaaatg      840

ctattttaaa gtagtttctt ccgccggggc agcaagagcg aaactccatc tcaaaaaata      900

ataataataa taaataaata aagtagtttc at                                    932


<210> 4326
<211> 1674
<212> DNA
<213> Homo sapiens

<400> 4326
atagagtagc ggaagtggtc cgttctcttc ctctcccggc ccaagcttct gggtatttct       60

attgcgcgag gcattgtggg ttgctgggcg gcccggtctc ggagaagagg ggagagtggc      120

gggccgctga ataagcttcc aaaatgatgg tgggtgatgg caccacctca gtgaccttgc      180

tggctgcaga gtttctgaag caggtgaaac cctatgtgga ggaaggttta cacccccaga      240

tcatcattcg agctttccgc acagccaccc agctggcagt taacaagatc aaagagattg      300

ctgtgaccgt gaagaaggca gataaagtgg agcagaggaa gctgctggaa aagtgtgcca      360

tgaccgctct gagctccaag ctgatctccc agcagaaagc tttctttgct aagatggtgg      420

tggatgcagt gatgatgctc gatgatttgc tgcagcttaa aatgattgga atcaagaagg      480

tacagggtgg agccctcgag gattctcagc tggtagctgg tgttgcattc aagaagactt      540

tctcttacgc tgggtttgaa atgcaaccca aaaagtacca caatcccaag attgcccttt      600

tgaatgtcga gctcgagttg aaagctgaga aagacaatgc tgagataaga gtccacacag      660

ttgaggatta tcaggcaatt gttgatgctg agtggaacat tctctatgac aagttagaga      720

agatccatca ttctggagcc aaagttgtct tgtccaaact ccccattggg gatgtggcca      780

cccagtactt tgctgacagg gacatgttct gtgctggccg agtacctgag gaggatctga      840

agaggacaat gatggcctgt ggaggctcaa tccagaccag tgtgaatgct ctgtcagcag      900

atgtgctggg tcgatgccag gtgtttgaag agacccagat tggaggcgag aggtacaatt      960

tttttactgg ctgccccaag gccaagacat gcaccttcat tctccgtggc ggcgccgagc     1020

agtttatgga ggagacagag cggtccctgc atgatgccat catgatcgtc aggagggcca     1080

tcaagaatga ttcagtggtg gctggtggcg gggccattga gatggaactc tccaagtacc     1140

tgcgggatta ctcaaggact attccaggaa aacagcagct gttgattggg gcatatgcca     1200

aggccttgga gattatccca cgccagctgt gtgacaatgc tggctttgat gccacaaaca     1260

ttctcaacaa gctgcgggct cggcatgccc aggggggtac atggtatgga gtagacatca     1320

acaacgagga cattgctgac aactttgaag ctttcgtgtg ggagccagct atggtgcgga     1380

tcaatgcgct gacagcagcc tctgaggctg cgtgcctgat cgtgtctgta gatgaaacca     1440

tcaagaaccc ccgctcgact gtggatgctc ccacagcagc aggccggggc cgtggtcgtg     1500

gccgccccca ctgagaggca ccccacccat cacatggctg gctggctgct gggtgcactt     1560

accctccttg gcttggttac ttcattttac aaggaagggg tagtaattgg cccactctct     1620

tcttactgga ggctatttaa ataaaatgta agacttcaga taactttgta aatt           1674


<210> 4327
<211> 2747
<212> DNA
<213> Homo sapiens

<400> 4327
gcatagctaa cttgcacatt cactatccaa gctgcaccat cttcggggtc attgtgtgcc       60

aggcatatca actcttttca ataaaaatgg atggaaaggc agatgtaaag tccctcatgg      120

cgaaatataa cacggggggc aacccgacag aggatgtctc agtcaatagc cgacccttca      180

gagtcacagg gccaaactca tcttcaggaa tacaagcaag aaagaactta ttcaacaacc      240

aaggaaatgc cagccctcct gcaggaccca gcaatgtacc taagtttggg tccccaaagc      300

cacctgtggc agtcaaacct tcttctgagg aaaagcctga caaggaaccc aagcccccgt      360

ttctaaagcc cactggagca ggccaaagat tcggaacacc agccagcttg accaccagag      420

accccgaggc gaaagtggga tttctgaaac ctgtaggccc caagcccatc aacttgccca      480

aagaagattc caaacctaca tttccctggc ctcctggaaa caagccatct cttcacagtg      540

taaaccaaga ccatgactta aagccactag gcccgaaatc tgggcctact cctccaacct      600

cagaaaatga acagaagcaa gcgtttccca aattgactgg ggttaaaggg aaatttatgt      660

cagcatcaca agatcttgaa cccaagcccc tcttccccaa acccgccttt ggccagaagc      720

cgcccctaag taccgagaac tcccatgaag acgaaagccc catgaagaat gtgtcttcat      780

caaaagggtc cccagctccc ctgggagtca ggtccaaaag cggcccttta aaaccagcaa      840

gggaagactc agaaaataaa gaccatgcag gggagatttc aagtttgccc tttcctggag      900

tggttttgaa acctgctgcg agcaggggag gcccaggtct ctccaaaaat ggtgaagaaa      960

aaaaggaaga taggaagata gatgctgcta agaacacctt ccagagcaaa ataaatcagg     1020

aagagttggc ctcagggact cctcctgcca ggttccctaa ggccccttct aagctgacag     1080

tgggggggcc atggggccaa agtcaggaaa aggaaaaggg agacaagaat tcagccaccc     1140

cgaaacagaa gccattgcct cccttgttta ccttgggtcc acctccacca aaacccaaca     1200

gaccaccaaa tgttgacctg acgaaattcc acaaaacctc ttctggaaac agtactagca     1260

aaggccagac gtcttactca acaacttccc tgccaccacc tccaccatcc catccggcca     1320

gccaaccacc attgccagca tctcacccat cacaaccacc agtcccaagc ctacctccca     1380

gaaacattaa acctccgttt gacctaaaaa gccctgtcaa tgaagacaat caagatggtg     1440

tcacgcactc tgatggtgct ggaaatctag atgaggaaca agacagtgaa ggagaaacat     1500

atgaagacat agaagcatcc aaagaaagag agaagaaaag ggaaaaggaa gaaaagaaga     1560

ggttagagct ggagaaaaag gaacagaaag agaaagaaaa gaaagaacaa gaaataaaga     1620

agaaatttaa actaacaggc cctattcaag tcatccatct tgcaaaagct tgttgtgatg     1680

tcaaaggagg aaagaatgaa ctgagcttca agcaaggaga gcaaattgaa atcatccgca     1740

tcacagacaa cccagaagga aaatggttgg gcagaacagc aaggggttca tatggctata     1800

ttaaaacaac tgctgtagag attgactatg attctttgaa actgaaaaaa gactctcttg     1860

gtgccccttc aagacctatt gaagatgacc aagaagtata tgatgatgtt gcagagcagg     1920

atgatattag cagccacagt cagagtggaa gtggagggat attccctcca ccaccagatg     1980

atgacattta tgatgggatt gaagaggaag atgctgatga tggctccaca ctacaggttc     2040

aagagaagag taatacgtgg tcctggggga ttttgaagat gttaaaggga aaagatgaca     2100

gaaagaaaag tatacgagag aaacctaaag tctctgactc agacaataat gaaggttcat     2160

ctttccctgc tcctcctaaa caattggaca tgggagatga agtttacgat gatgtggata     2220

cctctgattt ccctgtttca tcagcagaga tgagtcaagg aactaatgtt ggaaaagcta     2280

agacagaaga aaaggacctt aagaagctaa aaaagcagga aaaagaagaa aaagacttca     2340

ggaaaaaatt taaatatgat ggtgaaatta gagtcctata ttcaactaaa gttacaactt     2400

ccataacttc taaaaagtgg ggaaccagag atctacaggt aaaacctggt gaatctctag     2460

aagttataca aaccacagat gacacaaaag ttctctgcag aaatgaagaa gggaaatatg     2520

gttatgtcct tcggagttac ctagcggaca atgatggaga gatctatgat gatattgctg     2580

atggctgcat ctatgacaat gactagcact caactttggt cattctgctg tgttcattag     2640

gtgccaatgt gaagtctgga ttttaattgg catgttattg ggtatcaaga aaattaatgc     2700

acaaaaccac ttattatcat ttgttatgaa atcccaatta tctttac                   2747


<210> 4328
<211> 1758
<212> DNA
<213> Homo sapiens

<400> 4328
cttgcgtcct tccggctccg tcgtggaagc aggactgcgc cgcgtcttcc tcaaggttga       60

gaacaaaaac atgcacctgg agtttccccg gagccctctg cgtggttgag cttcggtgga      120

atttcggggc tcttggctgc cagccgcgct tgcctggtag caacagaaac cagtcctgct      180

cgcctccgtg gacatttcat taccatccag aagtgtctcc cactgaaggc atccgtggtt      240

gtttttaagc cacaaaaaag ccacacccaa gatcacctga cacccaccct gacaagtgtc      300

catgatgctg ggccctgagg gaggtgaagg ctttgtggtc aagctccgtg gcctgccctg      360

gtcctgctct gttgatgatg taaaaatggc cctgaaaaaa gacagggaaa gcatgggaca      420

ccggtacatt gaggtgttca agtcccacag aaccgagatg gattgggtgt tgaagcacag      480

tggtcccaac agtgccgaca gcgccaacga tggcttcgtg cggcttcgag gactcccatt      540

tggatgcaca aaggaagaaa ttgttcagtt cttctcaggg ttggaaattg tgccaaacgg      600

gatcacattg cctgtggacc ccgaaggcaa gattacaggg gaagcgttcg tgcagtttgc      660

ctcgcaggag ttagctgaga aggctctagg gaaacacaag gagaggatag ggcacaggta      720

cattgaggtg tttaagagca gccaggagga agttaggtca tactcagatc cccctctgaa      780

gttcatgtcc gtgcagcggc cagggcccta tgaccggccc gggactgcca ggaggtacat      840

tggcatcgtg aagcaggcag gcctggaaag gatgaggcct ggtgcctaca gcacaggcta      900

cgggggctac gaggagtaca gtggcctcag tgatggctac ggcttcacca ccgacctgtt      960

cgggagagac ctcagctact gtctctccgg aatgtatgac cacagatacg gcgacagtga     1020

gttcacagtg cagagcacca caggccactg tgtccacatg aggggcctgc cgtacaaagc     1080

gaccgagaac gacatttaca acttcttctc tcctctcaac cctgtgagag tccatattga     1140

gattggccca gatggaagag tgacgggtga agcagatgtt gagtttgcta ctcatgaaga     1200

agctgtggca gctatgtcca aagacagggc caatatgcag cacagatata tagaactctt     1260

cttgaattca acaacagggg ccagcaatgg ggcgtatagc agccaggtga tgcaaggcat     1320

gggggtgtct gctgcccagg ccacttacag tggcctggag agccagtcag tgagtggctg     1380

ttacggggcc ggctacagtg ggcagaacag catgggtggc tatgactagt tttgttagga     1440

acatttgagt tacttcaatc attttcacag gcagccaaca agcaattaag agcagttata     1500

atagaggaag ctgggggacc cattttgcac catgagtttg tgaaaaatct ggattaaaaa     1560

attacctctt cagtgttttc tcatgcaaaa ttttcttcta gcatgtgata atgagtaaac     1620

taaaactatt ttcagctttt ctcaattaac attttggtag tatacttcag agtgatgtta     1680

tctaagttta agtagtttaa gtatgttaaa tgtggatctt ttacaccaca tcacagtgaa     1740

cacactgggg agacgtgc                                                   1758


<210> 4329
<211> 1935
<212> DNA
<213> Homo sapiens

<400> 4329
gagcggaccc tcgcggcggc catggcgtcg gtggtggaat acaagggcct cagggccggc       60

taccactgcg gctactgcga ttccaaggag ggcaaagcgt cctgcggcat gtgggcacat      120

tccatgacag tacaggatta tcaggatctc atagaccgag gatggcgaag aagtggaaaa      180

tatgtgtaca aacctgtcat gaatcaaaca tgttgtcctc agtacacaat aaggtgccga      240

cctttacaat ttcagccttc aaaatctcac aagaaggttt tgaaaaaaat gttgaaattt      300

ctagctaaag gggaggttcc caaaggaagt tgtgaggatg agcccatgga ttccacaatg      360

gatgatgctg ttgcgggtga ctttgcattg ataaataaac tggatataca gtgtgatctt      420

aaaacactca gtgatgacat caaagagagt ttagagagtg aaggaaaaaa ttcaaagaaa      480

gaagaacctc aggaattact tcagtcacaa gatttcgtag gagagaagtt gggctctggt      540

gaaccgtcac attcagttaa agttcacaca gttcctaagc caggcaaagg ggctgatttg      600

agtaagcctc catgtcgaaa agcaaaggaa atccggaaag aaaggaaaag gttaaaacta      660

atgcagcaga acccagctgg agaacttgag ggtttccagg ctcaaggtca cccaccatct      720

ttgtttccac caaaggctaa atccaaccag ccaaaatcac tcgaagattt aatttttgag      780

tctttaccag agaatgcatc acacaagtta gaggtgaggt tagtacctgt ctcctttgag      840

gacccagagt tcaagtcgtc tttcagccag tccttttctt tgtatgtcaa gtatcaagtg      900

gccatacacc aggatccacc cgatgaatgt gggaagactg agttcacaag attcctttgc      960

agttcaccct tggaggcaga gactccccct aatgggccag attgtggcta tggctccttt     1020

caccagcagt actggcttga cggaaagatc attgctgtgg gggtgattga catcctccca     1080

aactgtgtat catctgtgta tttgtactac gatcctgatt attcgttttt gtctttgggc     1140

gtctactctg cactacgaga aattgctttt actaggcagc ttcatgagaa aacttctcaa     1200

ctcagctatt attatatggg tttctacatt cattcatgtc ccaagatgaa atataagggt     1260

cagtatagac cttctgattt gctgtgccct gagacatatg tttgggtacc cattgagcaa     1320

tgcctgcctt cacttgaaaa ctccaagtac tgccgtttca accaggaccc agaagcagtg     1380

gatgaggatc gcagtacgga acctgaccga ttgcaggtgt ttcacaagag agccatcatg     1440

ccttacggtg tttataagaa acagcagaaa gacccaagtg aggaggctgc tgttctgcag     1500

tacgccagcc tggtggggca gaagtgctcc gagcggatgc tgctgttcag aaactgacct     1560

gttcacctct gccgggaagt tcctgtgttg tgctgatgat ttgtgccagg atacatattc     1620

agtacctgtg gggaaataac tgtcaccacc cacaaattag acatttttta ttttgactat     1680

ctatggcttt taaaaaatat tttgtggcaa tgtatctgtg agaatctcat agttaatata     1740

aagattttaa aactgcatta tgacctagcc cccataattg ggatttatca ttttggagga     1800

ttctttctag agcaagatac gctcaaattc tcctgtttgt attttgtaaa atgaagaagt     1860

gaatctaagt aacttaatca cagttgtgca ttttttttgg ttctgttaga gaaattaaaa     1920

cagactgttt cctca                                                      1935


<210> 4330
<211> 5697
<212> DNA
<213> Homo sapiens

<400> 4330
aaaaataatg ccattttttt gaatgatgaa ctatggtata atgcatttag tgttcattcc       60

aaacgtcaat caataaataa catgggcctc tagctataag ggaaattcta taggtaaaag      120

aactgattga cccccacccc cataggtgct gtcctgctat ggaatccctt tgctcagttt      180

tctcctgtcc aatcaggtgg aatgtttcac aggcacatgg tttatacagc tcaaaataac      240

ttgggacctg tgagctgaca aatgctctgg ctccggtggt gacaggttgt ccagcttctt      300

acagccatct tcactgaaac taaggttaac tcctcactct ctatggacgg ctactctcta      360

tttccaaggg cgtgaagaat ttccctcttc tcctgtgctt tcatctaaaa gttctccctg      420

gataattatc attgcagtgg agtgcctgga ttggacatcc tcatctgggt caactaaaaa      480

aagaaagcat gcaagacgac agcatagaag cttctacttc catatctcag cttctaagag      540

agagctattt agctgaaacc agacatcggg gaaacaatga gaggagtcga gcggagccct      600

cctccaaccc ttgccatttc ggcagtcctt ctggggccgc tgaaggaggc ggaggccaag      660

atgaccttcc agatctttca gcctttctga gccaagaaga attagacgaa agtgtcaatt      720

tggcaagact ggccatcaat tacgaccctt tggagaaggc agatgaaact caagctagaa      780

aacgactttc tcctgatcag atgaaacact cacctaattt aagttttgag cctaacttct      840

gccaggataa ccctcgaagt cccaccagct ctaaagaaag cccccaggag gcaaaaaggc      900

cacagtattg ttctgaaacc cagtccaaaa aagtattttt aaataaggct gccgacttca      960

ttgaagagct atcctccctt ttcaaatccc acagctccaa aaggattaga cctcgtgcct     1020

gcaaaaacca caagagtaaa ctggaatctc aaaacaaagt tatgcaggaa aacagctcca     1080

gtttctcaga tctgtcagaa agacgagaaa gatcttctgt tcccatccct atccctgcgg     1140

ataccaggga taatgaagtg aatcacgccc tggaacagca ggaagccaag aggcgtgaag     1200

cggagcaggc tgccagtgag gcggctggtg gagacactac accagggtct tccccttcat     1260

ctctgtacta tgaagaacct ctggggcaac ctccccggtt cactcaaaag ttacggagca     1320

gagaagttcc agaaggaact cgagtacagt tggattgcat agtggtagga attccaccac     1380

ctcaagtaag gtggtactgt gaaggcaagg agcttgaaaa ttccccagat attcacatcg     1440

tccaggcagg aaatctgcac tcactgacca ttgcggaagc ctttgaagag gacacaggac     1500

gctattcctg ctttgcttct aacatctatg ggacagattc gacttctgct gagatttata     1560

tagaaggggt ttcttcttct gactcagaag gcgaccctaa caaggaagag atgaatcgaa     1620

tccagaagcc aaatgaggtg tcatctcctc ccactacctc tgcagtcatt cctccagcag     1680

taccccaagc ccagcatttg gtggcccaac ctcgtgtggc aaccatccag cagtgtcaga     1740

gccccaccaa ttacttgcag ggattggatg gaaaacctat cattgcagct cctgtgttta     1800

caaagatgct acaaaatttg tcagcttctg agggtcagct ggttgtcttt gaatgcagag     1860

taaaaggagc tccatctcct aaggttgagt ggtatagaga agggacttta atagaagatt     1920

ctccagattt taggatttta cagaaaaggc ctgtctgcat ggagcatata gaggagattt     1980

gcaccttggt cattgctgag gtgtttgcag aagattctgg gtgcttcaca tgtactgcaa     2040

gcaacaaata cggcacagtg tcaagcattg cacagctgca cgtgagagga aatgaggacc     2100

tcagcaacaa cgggtctctt cactcagcca actctaccac caacctggca gctattgagc     2160

cacagccctc cccaccccac tcagagcctc catctgtgga acaacccccc aaacccaaac     2220

tcgagggggt tctggtgaac cacaatgagc cccggtccag ctccaggatt gggcttcgtg     2280

tgcacttcaa cctgcctgaa gatgacaaag gaagtgaagc atcctccgag gctggtgtgg     2340

tgaccaccag acagaccagg cccgattctt tccaggagag gttcaacgga caggcaacaa     2400

aaaccccaga gccttcttcc cccgtgaaag agccccctcc agttctggcc aaacccaaac     2460

ttgattccac tcagttacaa cagcttcata accaagtctt actggaacaa caccaattgc     2520

aaaacccacc tccttcatct cctaaggagt ttcctttcag catgactgtt ttgaactcca     2580

atgctccccc agcggtgaca acatccagta agcaggtgaa ggctccttca tcacagacgt     2640

tcagcttggc ccggccgaag tatttcttcc cctccacgaa caccaccgca gcaactgtgg     2700

ccccttccag ctctccggtg ttcactttga gcagcactcc tcaaactatt cagaggacag     2760

tgagcaaaga aagcctctta gtgtctcacc cctctgtgca aaccaaatct ccaggagggc     2820

tttccatcca aaatgagcca ctcccaccag gcccaacaga accaacacca ccaccattca     2880

cattttccat ccccagcgga aaccagtttc agccccgctg tgtgtcccca attcctgtct     2940

ctcctaccag ccggattcag aacccagtgg ctttcctcag ctctgttctg ccttctctcc     3000

ctgccatccc acccacaaat gccatggggc tgcctagaag tgcaccatcc atgccatccc     3060

agggattagc gaagaaaaat acaaagtctc ctcaaccagt gaatgatgat aacattcgtg     3120

aaactaagaa cgcagtgatt cgagacttgg ggaaaaaaat aactttcagt gatgtcagac     3180

caaaccagca ggagtacaaa atttcaagct ttgagcagag gctgatgaat gaaatagagt     3240

ttcgcttgga acgtactcct gttgatgaat cagatgatga aattcaacat gatgagatcc     3300

ccacgggcaa gtgtattgct cccatctttg acaagagact caagcacttc cgggtcacag     3360

aaggctctcc agttacattc acctgcaaaa ttgttgggat acctgttcca aaggtttact     3420

ggttcaaaga tgggaagcag atttctaaga gaaatgagca ctgcaaaatg aggcgagaag     3480

gagatgggac atgctctctg cacattgaat ccactaccag tgatgacgat ggcaactaca     3540

ccatcatggc agccaacccc caggggagaa tcagctgttc tggccacttg atggtacaaa     3600

gtttgcccat tcgcagtcgg ctaacctctg ctggtcagtc tcacagggga agatcccgag     3660

tgcaagaaag agacaaagag cccctacagg aacgcttttt ccgaccacat ttcctgcagg     3720

ctcctgggga tatggtagct catgaggggc gcctctgtcg gctggactgt aaggtgagtg     3780

gtttaccgcc cccggagctg acatggctac tcaatggcca acctgtgcta ccagatgcct     3840

cccacaagat gctggtcagg gagaccggag tccactctct gctcattgac ccactcactc     3900

agcgcgacgc agggacctat aagtgcatcg ctaccaacaa aaccgggcag aattctttta     3960

gtctggagct ctctgtagta gccaaagagg tgaagaaagc acctgtgatc ctggagaaac     4020

tacagaactg cggtgttccc gaaggccacc ccgtgagact ggagtgccgc gtgataggca     4080

tgcccccacc tgtgttctac tggaagaaag acaatgagac catcccttgc accagagaga     4140

ggatcagtat gcaccaggac acaacagggt atgcctgcct tctcattcag ccagccaaga     4200

aatcagacgc tggatggtac acgttgtcag ccaagaatga agccggcatc gtgtcgtgca     4260

ctgccaggct ggatatatac gctcagtggc accatcagat cccaccgccc atgtctgtcc     4320

ggcccagtgg cagtcgctac ggatctctca ccagtaaagg acttgacata ttttctgcct     4380

tttcctccat ggaaagcacg atggtgtatt catgctcttc tcggagtgta gtggagagtg     4440

atgaacttta agaatgtcta ggtacctgct gtgtaagaga gcggactgtg gagggggaat     4500

gagaacaagc cagacttggt ggtttccaag caaccgaagt tgagtaagtt cccacactgc     4560

tggacctgtg gcaaagagtg ctttgaataa gtcagctagg gattcttgca gtctcagctg     4620

agggagaaag gtagggctgt gccttctaaa gattccaaca gagatgtgag aagataatac     4680

agatgaacca aagatgtcac acagttgcca tccactgctt tgggaaaaaa ctagcatgct     4740

cccctgctcc ctgttgtgtt agggatgttt aggtcatact aggagcaatt aggagccata     4800

tgcctgggct gagaagagct aggcagtagt gaccttagga tatgactaac tcaccaaaca     4860

atgccaagga gaaaggcgga caggtcacca tcacctttca tcgattacat gtatagcagt     4920

agttttggtg aattcaccaa atcagcttcc acttagcatt aggaggtcat gccatacaac     4980

tcacgtatgc gggcaaacac ttttgatttg catatcctgg gtgtactgag ccacataata     5040

aggtgtcaaa atgtgcttga gattccaaaa acttgctgaa acacttgata ttgcacagtg     5100

cacttatttt gtggccaaag catggcctta ccagcttgtc tgcactattt tcttttgggt     5160

ggtgactgtt tttttctgac tttgcatatc cctagacact agaactaaag gattggtaat     5220

aaaccaatca gaaagaaatc ctctgtgggg tcactttaaa aactactagc ttcaactacc     5280

acttacaaaa tgtgcaagag tcatcatttg cccataaaat acacctcatg ggctcctacc     5340

cctttcccca aaagtctgaa agtgtaggag gaaggaagag atacaaacaa ggagaggaaa     5400

tgatgggaga gtgttgtttt tgtcacttgc cccagcagag caggggtttt ggaaggagag     5460

gtctttaata gctttgaaat gctttgagat cattggtcaa attgcatttt ctatgtagag     5520

aatattctgc taggtggaaa agttgggaga aaggggaata tgcatcttta ttctaatcac     5580

caattcaaac cctgcctctt aaggaatttt tagacttaag ttcactgtga tatccctagt     5640

acctagaaga gtacctagca caaagtagac attcaataaa tatttgctgg ttgaatg        5697


<210> 4331
<211> 2882
<212> DNA
<213> Homo sapiens

<400> 4331
aagcatgtgc acaggctgct catgagttcc taaacgttgc gtttgcaaca ctaccagtgt       60

tttgtacggg cgctggcgcc tgctcacagc cttccacgtg accggaaaag gccttcagcg      120

cataaagtgg gagaccggaa gaggcggaga cgatccgatg ctcgaactcc gccccctctt      180

ctccgcgtag gcccagctcc ctgaagcggc tgtttcgagc cacgcgccca tcgggttaaa      240

aataagaagt tggttgagct gctgagaagg aaagttcgtc tcgcccagcc ttatgtcggc      300

gtctttctaa agagagatga cagcaatgag tcggatgtgg tcgagagcct ggatgaaatc      360

taccacacgg ggacgtttgc ccagatccat gagatgcagg accttgggga caagctgcgc      420

atgatcgtca tgggacacag aagagtccat atcagcagac agctggaggt ggagcccgag      480

gagccggagg cggagaacaa gcacaagccc cgcaggaagt caaagcgggg caagaaggag      540

gcggaggacg agctgagcgc caggcacccg gcggagctgg cgatggagcc cacccctgag      600

ctcccggctg aggtgctcat ggtggaggta gagaacgttg tccacgagga cttccaggtc      660

acggaggagg tgaaagccct gactgcagag atcgtgaaga ccatccggga catcattgcc      720

ttgaaccctc tctacaggga gtcagtgctg cagatgatgc aggctggcca gcgggtggtg      780

gacaacccca tctacctgag cgacatgggc gccgcgctca ccggggccga gtcccatgag      840

ctgcaggacg tcctggaaga gaccaatatt cctaagcggc tgtacaaggc cctctccctg      900

ctgaagaagg aatttgaact gagcaagctg cagcagcgcc tggggcggga ggtggaggag      960

aagatcaagc agacccaccg taagtacctg ctgcaggagc agctaaagat catcaagaag     1020

gagctgggcc tggagaagga cgacaaggat gccatcgagg agaagttccg ggagcgcctg     1080

aaggagctcg tggtccccaa gcacgtcatg gatgttgtgg acgaggagct gagcaagctg     1140

ggcctgctgg acaaccactc ctcggagttc aatgtcaccc gcaactacct agactggctc     1200

acgtccatcc cttggggcaa gtacagcaac gagaacctgg acctggcgcg ggcacaggca     1260

gtgctggagg aagaccacta cggcatggag gacgtcaaga aacgcatcct ggagttcatt     1320

gccgttagcc agctccgcgg ctccacccag ggcaagatcc tctgcttcta tggcccccct     1380

ggcgtgggta agaccagcat tgctcgctcc atcgcccgcg ccctgaaccg agagtacttc     1440

cgcttcagcg tcgggggcat gactgacgtg gctgagatca agggccacag gcggacctac     1500

gtgggcgcca tgcccgggaa gatcatccag tgtttgaaga agaccaagac ggagaacccc     1560

ctgatcctca tcgacgaggt ggacaagatc ggccgaggct accaggggga cccgtcgtcg     1620

gcactgctgg agctgctgga cccagagcag aatgccaact tcctggacca ctacctggac     1680

gtgcccgtgg acttgtccaa ggtgctgttc atctgcacgg ccaacgtcac ggacaccatc     1740

cccgagccgc tgcgagaccg tatggagatg atcaacgtgt cgggctacgt ggcccaggag     1800

aagctggcca ttgcggagcg ctacctggtg ccccaggctc gcgccctgtg tggcttggat     1860

gagagcaagg ccaagctgtc atcggacgtg ctgacgctgc tcatcaagca gtactgccgc     1920

gagagcggtg tccgcaacct gcagaagcaa gtggagaagg tgttacggaa atcggcctac     1980

aagattgtca gcggcgaggc cgagtccgtg gaggtgacgc ccgagaacct gcaggacttc     2040

gtggggaagc ccgtgttcac cgtggagcgc atgtatgacg tgacaccgcc cggcgtggtc     2100

atggggctgg cctggaccgc aatgggaggc tccacgctgt ttgtggagac atccctgaga     2160

cggccacagg acaaggatgc caagggtgac aaggatggca gcctggaggt gacaggccag     2220

ctgggggagg tgatgaagga gagcgcccgc atagcctaca ccttcgccag agccttcctc     2280

atgcagcacg cccccgccaa tgactacctg gtgacctcac acatccacct gcatgtgccc     2340

gagggcgcca cccccaagga cggcccaagc gcaggctgca ccatcgtcac ggccctgctg     2400

tccctggcca tgggcaggcc tgtccggcag aatctggcca tgactggcga agtctccctc     2460

acgggcaaga tcctgcctgt tggtggcatc aaggagaaga ccattgcggc caagcgcgca     2520

ggggtgacgt gcatcgtcct gccagccgag aacaagaagg acttctacga cctggcagcc     2580

ttcatcaccg agggcctgga ggtgcacttc gtggaacact accgggagat cttcgacatc     2640

gccttcccgg acgagcaggc agaggcgctg gccgtggaac ggtgacggcc accccgggac     2700

tgcaggcggc ggatgtcagg ccctgtctgg gccagaactg agcgctgtgg ggagcgcgcc     2760

cggacctggc agtggagcca ccgagcgagc agctcggtcc agtgacccag atcccaggga     2820

cctcagtcgg cttaatcaga gtgtggcata gaagctattt aatgattaaa gtcatttgca     2880

gt                                                                    2882


<210> 4332
<211> 1304
<212> DNA
<213> Homo sapiens

<400> 4332
gtggttctca aacctggtgg cccattagaa attttaaatg cctgagttcc accttggacc       60

agttctgtta gaatctctgc atgaccagcc aggatatcag tacttcttaa tttgcagcca      120

gggttcagaa ccactggcct cgagcttttt ctgggacttc taacacttgt cattgtccct      180

gggcaaagca tgagcatata cacatgttta tcaaaaagaa aaggaactta tatctagctc      240

cactggtcca actttagaaa ctaggaaacg agtaaatggt gtgtgtgtcc ccatttgtgt      300

gtctgcatct gcataaggtg gtgtgttggt gggcaccctt gctaatcaga gggtgtgctg      360

tgccatacca ctctggtgag ggtatgaatc tctgtgtgac tccttccttt gtttctcaca      420

gggctggttc ttgtgctgaa acaccacgat ggtgctgccc ataaactcgt gtgttatttc      480

accaactggg cacacagtcg gccaggccct gcctcgatct tgccccatga cctggacccc      540

tttctctgca cccacctgat atttgccttt gcctcaatga acaacaatca gattgttgct      600

aaggatctcc aggatgagaa aattctctac ccagagttca acaaactaaa ggagaggaac      660

agagagctga aaacactact gtccatcggc gggtggaact ttggcacctc aagattcacc      720

actatgttgt ccacatttgc caaccgtgaa aagtttattg cttcagttat atcccttctg      780

aggacacatg actttgatgg tcttgacctt ttcttcttat atcctggact aagaggcagc      840

cccatgcatg accggtggac ttttctcttc ttaattgaag agctcctgtt tgccttccgg      900

aaggaggcac tgctcaccat gcgcccgagg ctgctgctgt ctgctgctgt ttctggggtc      960

ccacacatcg tccaaacatc ctatgatgtg cgctttctag gaagatttgt tcctttgtct     1020

ggggagcgaa gaagcactgg attgattacc agtatgtccc gtatgccaac aaggggaaag     1080

agtgggttgg ctatgacaat gccatcagct tcagttacaa ggcatggttt ataaggcgag     1140

agcattttgg gggggccatg gtgtggacat tggacatgga tgacgtcagg ggcacgttct     1200

gtggcactgg ccctttcccc cttgtctacg tattgaatga tatcctggtg cgggctgagt     1260

tcagttcaac ttctttacca caattttggc tgtcatctgc tgtg                      1304


<210> 4333
<211> 1840
<212> DNA
<213> Homo sapiens

<400> 4333
atgttgggtc tgaagcggct gctgtaggcg ccgacggagc gagcgggcgt gcggagcggg       60

cgacagtggc gtgggatctg cctctctgcg agcagctggg agcggcggcg gcggcgccat      120

gagcgggggc accccttaca tcggcagcaa gatcagcctc atctccaagg cggagatccg      180

ctacgagggc atcctctaca ccatcgacac cgaaaactcc accgtagccc ttgccaaagt      240

tcgatccttt ggtacagaag acagaccgac agatcgtcca ataccacctc gagatgaagt      300

ctttgaatac attatattcc gtgggagtga cattaaagac cttactgttt gtgagccacc      360

aaaaccacag tgttctttgc ctcaagaccc agctattgtt cagtcctcac taggctcatc      420

gacttcttca ttccagtcca tgggttctta tggacctttc ggcaggatgc ccacatacag      480

tcagttcagt ccgagttcct tagttgggca gcagtttggt gctgttggtg ttggtcgctc      540

aagccctcag ttagaccctt tgagaaaaag cccaaccatg gaacaagcag tgcagaccgc      600

ctcagcccac ttacctgctc cagcagctgt tgggagaagg agtcctgtat caaccaggcc      660

tttgccatct gccagccaaa aggcaggaga gaatcaggag cacaggcgag ctgaagtaca      720

caaagtttca aggccagaaa atgagcaact cagaaatgat aacaagagac aagtagctcc      780

aggtgctcct tcagctccaa ggagagggcg tgggggtcat cggggtggca ggggaagatt      840

tggtattcgg cgagatgggc caatgaaatt tgagaaagac tttgactttg aaagtgcaaa      900

tgcacaattc aacaaggaag agattgacag agagtttcat aataaactta aattaaaaga      960

agataaactt gagaaacagg agaagcctgt aaatggtgaa gataaaggag actcaggagt     1020

tgatacccaa aacagtgaag gaaatgccga tgaagaagat ccacttggac ctaattgcta     1080

ttatgacaaa actaaatcct tctttgataa tatttcttgt gatgacaata gagaacggag     1140

accaacctgg gctgaagaaa gaagattaaa tgctgaaaca tttggaatcc cacttcgtcc     1200

aaaccgtggc cgtgggggat acagaggcag aggaggtctt ggtttccgtg gtggcagagg     1260

gcgtggtggt ggcagaggtg gtaccttcac tgcccctcga ggatttcgcg gtggattcag     1320

aggaggtcgt gggggccggg agtttgcgga ttttgaatat aggaaaacca cagcttttgg     1380

accctaaaag gtctggattg atcgtactgc tttctgaaag aaagacaaca aagttgctgc     1440

atagtctaca aacaagtctc tgaaaatagg tgaatttcta gctcttcatg gtcctgaaca     1500

ttgatttcag tctttgcaaa gaatgaagaa gtgaattcgc tgtacatttg tcaccagcac     1560

tgggtttttg ttttttgttt gtttttccgc ttaatttcaa agataaaatg cagttacttt     1620

tgggggtgga aggctcatct taaaacatga gcattaaata tatttggaat agcagaaggt     1680

taagtaattt cttatgtata gttaaactaa agcagtactt cagtgggact taacaagtat     1740

tttttcatca ctgaaaggtt tttttttttt atcactaaat tgtatttggc aattgcaagt     1800

tgcctgcaga tagggccgtg atactgtgtt ttgagccaca                           1840


<210> 4334
<211> 2873
<212> DNA
<213> Homo sapiens

<400> 4334
agcagcgcag gtgagcgccg cttccggggt cgggcgcctg gatagctgcc ggctccggct       60

tccacttggt cggttgcgcg ggagactatg gcgtcctcct cggtcccacc agccacggta      120

tcggcggcga cagcaggccc cggcccaggt ttcggcttcg cctccaagac caagaagaag      180

catttcgtgc agcagaaggt gaaggtgttc cgggcggccg acccgctggt gggtgtgttc      240

ctgtggggcg tagcccactc gatcaatgag ctcagccagg tgcctccccc ggtgatgctg      300

ctgccagatg actttaaggc cagctccaag atcaaggtca acaatcacct tttccacagg      360

gaaaatctgc ccagtcattt caagttcaag gagtattgtc cccaggtctt caggaacctc      420

cgtgatcgat ttggcattga tgaccaagat tacttggtgt cccttacccg aaaccccccc      480

agcgaaagtg aaggcagtga tggtcgcttc cttatctcct acgatcggac tctggtcatc      540

aaagaagtat ccagtgagga cattgctgac atgcatagca acctctccaa ctatcaccag      600

tacattgtga agtgccatgg caacacgctt ctgccccagt tcctggggat gtaccgagtc      660

agtgtggaca acgaagacag ctacatgctt gtgatgcgca atatgtttag ccaccgtctt      720

cctgtgcaca ggaagtatga cctcaagggt tccctagtgt cccgggaagc cagcgataag      780

gaaaaggtta aagaattgcc cacccttaag gatatggact ttctcaacaa gaaccagaaa      840

gtatatattg gtgaagagga gaagaaaata tttctggaga agctgaagag agatgtggag      900

tttctagtgc agctgaagat catggactac agccttctgc taggcatcca cgacatcatt      960

cggggctctg aaccagagga ggaagcgccc gtgcgggagg atgagtcaga ggtggatggg     1020

gactgcagcc tgactggacc tcctgctctt gtgggctcct atggcacctc cccagagggt     1080

atcggaggct acatccattc ccatcggccc ctgggcccag gagagtttga gtccttcatt     1140

gatgtctatg ccatccggag tgctgaagga gccccccaga aggaggtcta cttcatgggc     1200

ctcattgata tccttacaca gtatgatgct aagaagaaag cagctcatgc agccaaaact     1260

gtcaagcatg gggctggggc agagatctct actgtccatc cggagcagta tgctaagcga     1320

ttcctggatt ttattaccaa catctttgcc taagagactg cctggttctc tctgatgttc     1380

aaggagctag gggaaggggg ttgtttgcct tcttcaggac ctgactggac agatggacct     1440

ggctcaagca actactctgg atgcactttg ctgtgtggga tgaactaaaa gtgtctgaat     1500

tttgctgata actttataaa actcactatg gcatgcttcc ctcctggtgg gccctaggat     1560

ggatgacact caagatacta cagatgtggg tgcaggcatg cacacacacg atggaatatg     1620

gccattccta cacaggtggg gtagagagtg ggtcagcagc ctggcacctc acagaggtgg     1680

gacctaagag gactcatgat tatgcagaga attggattgg gtctctgtca tagattgagt     1740

aatctcttcc cttacctcaa ttccatctcc acccatctct acatctgggc acagcaaccc     1800

agagatggcc aaaagcattc aagcctgggg gaagatgttt gactattgct gctcttcacc     1860

agaacctcac acctctcctg ggactggaac ccttcagtgg gtgtgtggcc agttttggag     1920

gctggaatga tgggccaggg tgtaggattc attctccatg taaagtttcc tttcatcctg     1980

cctagccatc cccaaggttt atttccagaa gaaaggaata tctctacttg gatcaattct     2040

ggtcatttca agaggatgga ggcctcaagt gtgggaactt cccctactcc ctggatgtgt     2100

gtacctagca cacttccttc tcccacccct ttttccagtt ggatttgttt ttctgttctc     2160

ttctgtcctg tcttatactg caactgtgtc tcctagggga cagatggcct tctttgtcat     2220

cttcactctc cacccccaga gaggagtcag agccataact caatcactca gcccctccaa     2280

agatagttga tgtgtgataa tctcataatg ttgagaaccc tgatgagata cattgtcttc     2340

ctctccctac aatgcctctg gggccaaggc acccattctt cttgctatcc tccatccccc     2400

ttgaggcttc cacttttttt ttttttagac ataaagctgg gcatcagcaa ctggcctgtg     2460

gtgatgcaaa gctgctttgc tctgtatctg gctggactga tctgtctcac aagaagccat     2520

gaggccatag ggagaagctc cctctcccct tcatcttctg ctccaaaggt ggtagcaaga     2580

ggagtaccca gttaggggtt ggagccccca tataacatct tcctgtcaga agactgatgg     2640

atctttttca ttccaaccat ctccctttcc cccgatgaat gcaataaaac tctgtgacac     2700

cagcaaccat tgctctttag aaatgggttt tctgatcata tggctgatgt gttatgggca     2760

gtatggatgt cttcatttgt tgcttctgtt tttcatcttt tttgttttat taataaaaat     2820

ttatgtattt gctcctgtta ctataataat acagggaata aattattcaa tcc            2873


<210> 4335
<211> 1947
<212> DNA
<213> Homo sapiens

<400> 4335
gggccaagcg cccccggagg cgctaagctt gcgccctgag gcggtttccg ttcccggacg       60

tttggactct gtcctggaga aggggaagga aaaagtaaga cgtagaagta cactgagact      120

tcgtcacaca taaaacaagc acgacaaaga aagagggcgc gaagggactc ctggaagaaa      180

ttgagtctac atttaagatc accctaaaag tagtgacggc ctcttcatta ctccaaaccc      240

cagatttaag tcggtaggac gtcttcgcgt tgacttgtgg ggaatgtagt ttcgatgctg      300

ccggcgcgtt ttgtttgcga cagaaactac aacccccagg ggccaccgcg acgttgcctg      360

tgggtgcccg cgaaccaacg gttagcggtg gcaggggctg actgagagcg tctgcttgat      420

aatggattct gaattaatgc atagtatagt aggaagctat cataaacctc cagaaagagt      480

atttgttccc tcattcaccc agaatgaacc atctcagaat tgccatcctg caaacttaga      540

agttacctct cctaagatac ttcatagccc aaatagccaa gctcttattt tagccttaaa      600

aactcttcag gaaaaaattc atcgtttaga gctggagaga acacaagctg aagataacct      660

gaacattctt tccagagaag cagcacagta taagaaggcc ttagagaatg aaacaaatga      720

gagaaatctg gcacaccagg agctgataaa gcagaaaaaa gatataagta tacagttaag      780

ctcagcccag tctcgttgta ctcttctaga gaagcaacta gaatatacaa agagaatggt      840

tctcaacgta gagcgagaaa agaacatgat cctagaacaa caggcccagc ttcagaggga      900

aaaagaacaa gatcagatga agctgtatgc aaaacttgaa aagcttgatg tcttagaaaa      960

agagtgtttc agacttacaa caactcagaa aactgctgag gacaagatta aacatttaga     1020

agaaaaactt aaggaagaag aacatcagcg taagctattt caagacaaag cttctgagct     1080

tcaaactgga cttgaaatca gtaaaattat aatgtcttca gtttcaaatc taaagcactc     1140

caaggaaaag aagaaatctt caaaggtgtg catataaaat tttttcccaa acaaaaatac     1200

tgctaatact tattcaggtt aaaaaaagta gcagcagtca tgtacaaaat ttagctctga     1260

gtttgcttga caaccaaagc aaaaaggaac atataatgga cagtatagct atctttgtga     1320

aataacagga agcactccag tttttctaga aagattaaca tttttctagt tttaaacttc     1380

tggagaaaca tattttgtga tagtttataa aagaggcagt aaacaacaca gtagatactg     1440

acaacataat aaatcctgaa agcagtttta tgtaatatat agacaataaa aaataaggtt     1500

tttcttatag acctgttaag tctgtaaagt catttatata gggaatttat tgttatatgt     1560

aatttctatg cttatttctt gtgaatttgc ccaaaagtaa ggattggaga gttagtactt     1620

tatagaccaa tattttgttt agatggattg atgttttgaa tgtatgctat tcaagtaacc     1680

cttcttaatt atatataatg gtatgaaaaa agtttttaat cccttttaat cttatgattg     1740

tggaattatg gttttgatgg ccattattac tatttattca gatatgaatg gagtgagtgt     1800

tctctgtgcc atttgttgtg ggggacagga gatgctattt gggaattctg gccactgcca     1860

tatgcttagc ttgtggataa aataatggag agaacagtaa acttaacttt ggctactctt     1920

ttattacgta aataaaaatt aatgttc                                         1947


<210> 4336
<211> 2360
<212> DNA
<213> Homo sapiens

<400> 4336
agagcctgag caggcagggc acctccaggt gggcaggagc taccactcag caccatgagc       60

accgccacag gcacctggtg acgttctgcc tgggtgagga cgatggcgtg cataccgtgg      120

aggatgcctc caggaagttg gccgtcatgg atagccaggg ccgagtctgg gcacaggaga      180

tgctgctgcg agtgtctccc gaccatgtca cgctgctcga cccggcctcc aaggaggagc      240

tggagtcgta cccactgggc gccatcgtgc gctgtgacgc ggtgatgcca cccggcagga      300

gccgctcgtt gctgctgctc gtgtgccagg aacccgagcg cgcgcagccc gacgtgcact      360

tcttccaggg cctgcgcctc ggggcggagc tgatccgaga ggacatccag ggggctctgc      420

acaattaccg ctcgggccgc ggggagcgca gggcggcggc gctcagggcc acgcaggagg      480

agttgcagcg cgaccgctcg cccgccgctg agaccccgcc cctgcagcgc cgcccgtcag      540

tccgcgcagt gatcagcacc gtagagcggg gcgcgggccg cggacgaccc caggcgaagc      600

ccattcccga ggcagaggag gcgcagaggc ctgagccggt ggggacctcg agcaacgctg      660

actcggcctc cccggacctg ggtccccggg gtcctgacct ggcggttctg caggcggagc      720

gggaagtgga catcctgaac cacgtgttcg acgacgtaga gagctttgta tcgaggctgc      780

agaagtcggc ggaggcggcc agggtgctgg agcaccggga acgcggccgc aggagccggc      840

gccgggcggc tggggagggc ttgctgacgc tgcgggccaa gccgccctcg gaggccgagt      900

acaccgacgt gctgcagaag atcaagtacg ccttcagcct gctggcccgg ctgcgcggca      960

acatcgccga cccctcctct ccggagctgt tgcacttcct tttcgggcct ctgcagatga     1020

ttgtgaacac gtcggggggg ccggagttcg cgagcagtgt gcggcggccg catctgacat     1080

cggatgccgt ggcgctgctg cgggacaacg tcactccacg tgaaaacgag ctctggacct     1140

cgctggggga ctcgtggacc cgccccgggc tggagctgtc cccggaggag ggacccccat     1200

acagacccga gttcttcagc ggctgggagc cgccggtcac tgacccgcag agccgcgcct     1260

gggaggaccc agttgagaaa cagctacagc acgagcggag gcgccggcag caaagcgccc     1320

cccaggtcgc tgtcaatggt caccgagact tggagccaga atctgagcct cagctggagt     1380

cagagacagc aggaaaatgg gtcctgtgta attatgactt ccaggcccgc aacagcagtg     1440

agctgtcggt caagcagcgg gacgtactgg aggtcctgga tgacagtcgt aagtggtgga     1500

aggttcggga cccagcgggg caggagggat atgtgcccta caacatcctg acaccctacc     1560

ccggaccccg gctgcaccac agccaaagcc ctgcccgcag cctgaacagc actcctcctc     1620

caccaccagc cccagccccg gccccacctc cagctctggc tcggccccgc tgggacaggc     1680

cccgctggga cagctgcgat agcctcaacg gcttggaccc cagcgagaag gagaaattct     1740

cccagatgct catcgtcaac gaggaactgc aggcgcgcct ggcccagggc cgctcgggac     1800

cgagccgcgc agtcccaggg ccccgcgccc cggaaccgca gctcagcccg ggctcggacg     1860

cctccgaggt ccgcgcctgg ctgcaggcca agggctttag ctccgggacc gtggacgcgc     1920

tgggtgtgct gaccggggcg cagcttttct cgctgcagaa ggaggagctg cgggcggtga     1980

gccccgagga gggggcacgt gtgtacagcc aggtcaccgt gcagcgctcg ctgctggagg     2040

acaaagagaa agtgtcagag ctggaggcag tgatggagaa gcaaaagaag aaggtggaag     2100

gcgaggtgga aatggaggtc atttgacctg ccaggcgccc ttcgcaaaga gtgacgaggc     2160

cccgtgggag aacggactcc tcagactctc cccaatagcg gaagtcgatc ttctgaagga     2220

tggccaatct gctccggccc tggtcttccc ccatcccggt ggacagactt aacgatcctt     2280

gctgcagtcc ctccggagag gatctggact ggctgggagt ggggagggcg tggagacagt     2340

ctacggaaag cgctagcaga                                                 2360


<210> 4337
<211> 3795
<212> DNA
<213> Homo sapiens

<400> 4337
aaggtccgcg gggggcgagc gcgggtcggg ggccgtcccg gacccaccat gaacaccaag       60

aagagaggga gccccgcgcg gactcactct atgatgtccc tgtcggtgcg gccgcagcgc      120

cgtctgctca gcgcccgggt caataggagc cagtccttcg caggcgtcct cggcagccac      180

gagcgggggc ccaggagttt cccggtcttc agcccgccgg ggcccccacg gaagcccccc      240

gcgctctccc gagtgtccag gatgttttcc gtggctcacc cagccgccaa ggtgccgcag      300

cccgagcggc tggacctggt gtacacggcg ctgaagcggg gcctgacggc ctacttggaa      360

gtgcaccagc aggagcaaga gaaactccag gggcagataa gggagtccaa gaggaattcc      420

cgcttgggct tcctgtatga tctggacaag caagtcaagt ccattgaacg cttcctgcga      480

cgactggagt tccatgccag caagatcgat gagctgtatg aggcatactg tgtccagcgg      540

cgtctccggg atggtgccta caacatggtc cgtgcctaca ccactgggtc cccgggaagc      600

cgagaggccc gggacagcct ggcagaggcc actcgggggc atcgcgagta cacggagagc      660

atgtgtctgc tggagagcga gctggaggca cagctgggcg agtttcatct ccgaatgaaa      720

gggctggctg gcttcgccag gctgtgtgta ggcgatcagt atgagatctg catgaaatat      780

gggcgtcagc gctggaaact acggggccga attgagggta gtggaaagca ggtgtgggac      840

agtgaagaaa ccatctttct ccctctactc acggaatttc tgtctattaa ggtgacagaa      900

ctgaagggcc tggccaacca tgtggttgtg ggcagtgtct cctgtgagac caaggacctg      960

tttgccgccc tgccccaggt tgtggctgtg gatatcaatg accttggtac catcaagctc     1020

agcctggaag tcacatggag ccccttcgac aaggatgacc agccctcagc tgcttcttct     1080

gtcaacaagg cctccacagt caccaagcgc ttctccacct atagccagag cccaccggac     1140

acaccctcac ttcgggaaca ggctttctat aacatgctgc gacggcagga ggagctggag     1200

aatgggacag catggtccct gtcatctgaa tcttcagacg actcatccag cccacagctc     1260

tcaggcactg cccgccactc accagcccct aggcccctgg tgcagcagcc cgagcccctt     1320

cccatccaag ttgccttccg caggcctgag acccccagct ctgggccctt ggatgaggag     1380

ggggccgtgg ccccagtcct ggcaaatggg catgcaccct acagtcggac tctgagccac     1440

atcagtgagg ctagtgtaga tgctgccttg gctgaggctt cagtggaggc cgttggccca     1500

gaaagcctag cctggggacc tagcccacct acacacccag ctcccaccca tggagagcac     1560

cccagtcctg ttcctcctgc cctggaccct ggccactctg ccacaagctc taccctcggt     1620

acaacaggct ctgtccccac atctacagac cctgccccat ctgcacacct agactcagtt     1680

cataagtcca cagactctgg cccttcagaa ctgccaggcc ccactcacac cactacaggc     1740

tctacctata gtgccattac cactacccac agtgctccaa gccccctcac tcacactact     1800

acaggctcca cccacaagcc cataatctct acccttacta ctacaggccc taccctcaat     1860

atcataggcc cagtccagac taccacaagc cccacccaca ctatgccaag ccctacccat     1920

accacagcaa gccccactca tacttccaca agccccaccc atacccccac aagtcccacc     1980

cacaaaacca gtatgtcacc tcccaccact acaagtccta cccccagtgg tatgggccta     2040

gtccagactg ccacaagtcc cacccatcct accacaagcc ccacccatcc caccacaagc     2100

cccatcctta taaatgtaag cccttccact tctctagaac ttgctaccct ctccagcccc     2160

tccaaacact cagaccccac cctcccaggc actgactccc ttccctgtag tcccccagtc     2220

tccaattcct acactcaggc agaccctatg gcccccagaa ctccccaccc aagtcctgcc     2280

cattccagta ggaaacccct cacaagccct gccccagatc cctcagagtc tacggttcag     2340

agtctaagcc ccactccctc acccccaacc cctgcacccc agcattcaga cctttgcctg     2400

gccatggctg tccagacccc agtcccaacg gcagccggag ggtctgggga caggagcctg     2460

gaggaggcac tgggggccct aatggctgcc ctggatgact accgtggcca gtttcctgag     2520

ctgcagggcc tggagcagga ggtgacccgc ctagaaagtc tgctcatgca gagacaaggt     2580

ctgactcgca gccgggcctc cagtctcagc atcactgtgg agcatgcctt ggagagcttc     2640

agcttcctca atgaagacga agatgaagac aatgatgttc ctggggacag gcctccaagc     2700

agcccggagg ctggggctga ggacagcata gactcaccca gtgcccgccc cctcagcacg     2760

gggtgtccag ctctggatgc tgccttggtc cggcacctgt accactgcag tcgcctcctg     2820

ctgaaactgg gcacatttgg gcccctgcgc tgccaggagg catgggccct ggagcggctg     2880

ctgcgggaag cccgagtact ggaggcagta tgcgagttca gcaggcggtg ggagatcccg     2940

gccagctctg cccaggaagt ggtgcagttc tcggcctctc ggcctggctt cctgaccttc     3000

tgggaccagt gcacagagag actcagctgc ttcctctgcc cggtggagcg ggtgcttctc     3060

accttctgca accagtatgg tgcccgcctc tccctgcgcc agccaggctt ggctgaggct     3120

gtgtgtgtga agttcctgga ggatgccctg gggcagaagc tgcccagaag gccccagcca     3180

gggcctggag agcagctcac agtcttccag ttctggagtt ttgtggaaac cttggacagc     3240

cccaccatgg aggcctacgt gactgagacc gctgaggagg tgctactggt gcggaatctg     3300

aactcggatg atcaggctgt tgtgctgaag gccctgagat tggcgcccga ggggcgtctg     3360

cgaagggacg ggctgcgggc cctcagctcc ctgctcgtcc atggcaacaa caaggtcatg     3420

gctgctgtca gcacccagct ccggagcctg tcactgggcc ctaccttccg ggagagggcc     3480

ctcctgtgct tcctggacca gctggaggat gaggacgtgc agactcgagt ggctggctgc     3540

ctggccctag gctgcatcaa ggctcccgag ggcattgagc ccctggtgta cctctgccaa     3600

actgacacag aagctgtgag ggaagctgcc cggcaaagcc tacagcagtg tggagaagag     3660

ggacagtctg cccatcgacg gctggaggag tccctggacg ccctgccccg catctttggg     3720

cctggcagca tggccagcac agcattctaa actattcacc catgggttcc tggtgcccct     3780

ttccccccac tttca                                                      3795


<210> 4338
<211> 1774
<212> DNA
<213> Homo sapiens

<400> 4338
gctcctcgct tcctccgcgg tcttccgagc ggtcgcgtga actgcttcct gcaggctggc       60

catggcgctt cacgttccca aggctccggg ctttgcccag atgctcaagg agggagcgaa      120

acacttttca ggattagaag aggctgtgta tagaaacata caagcttgca aggagcttgc      180

ccaaaccact cgtacagcat atggaccaaa tggtacagca tcctgctgca aaaatgattg      240

taatggcttc tcatatgcaa gagcaagaag ttggagatgg cacaaacttt gttctggtat      300

ttgctggagc tctcctggaa ttagctgaag aacttctgag gattggcctg tcagtttcag      360

aggtcataga aggttatgaa atagcctgca gaaaagctca tgagattctt cctaatttgg      420

tatgttgttc tgcaaaaaac cttcgagata ttgatgaagt ctcatctcta cttcgtacct      480

ccataatgag taaacaatat ggtaatgaag tatttctggc caagcttatt gctcaggcat      540

gcgtatctat ttttcctgat tccggccatt tcaatgttga taacatcaga gtttgtaaaa      600

ttctgggctc tggtatcagt tcctcttcag tattgcatgg catggttttt aagaaggaaa      660

ccgaaggtga tgtaacatct gtcaaagatg caaaaatagc agtgtactct tgtccttttg      720

atggcatgat aacagaaact aagggaacag tgttgataaa gactgctgaa gaattgatga      780

attttagtaa gggagaagaa aacctcatgg atgcacaagt caaagctatt gctgatactg      840

gtgcaaatgt cgtagtaaca ggtggcaaag tggcagacat ggctcttcat tatgcaaata      900

aatataatat catgttagtg aggctaaact caaaatggga tctccgaaga ctttgtaaaa      960

ctgttggtgc tacagctctt cctagattga cacctcctgt ccttgaagaa atgggacact     1020

gtgacagtgt ttacctctca gaagttggag atactcaggt ggtggttttt aagcatgaaa     1080

aggaagatgg cgccatttct accatagtac ttcgaggctc tacagacaat ctgatggatg     1140

acatagaaag ggcagtagac gatggtgtta atactttcaa agttcttaca agggataaac     1200

gtcttgtacc cggaggtgga gcaacagaaa ttgaattagc caaacagatc acatcatatg     1260

gagagacatg tcctggactt gaacagtatg ctattaagaa gtttgctgag gcatttgaag     1320

ctattccccg cgcactggca gaaaactctg gagttaaggc caatgaagta atctctaaac     1380

tttatgcagt acatcaagaa ggaaataaaa acgttggatt agatattgag gctgaagtcc     1440

ctgctgtaaa ggacatgctg gaagctggta ttctagatac ttacctggga aaatattggg     1500

ctatcaaact cgctactaat gctgcagtca ctgtacttag agtggatcag atcatcatgg     1560

caaaaccagc tggtgggccc aagcctccaa gtgggaagaa agactgggat gatgaccaaa     1620

atgattgaaa ttggcttaat ttttactgta ggtgaaggct gtatttgtag tagtactcaa     1680

gaatcacctg atgttttctt attctcctta aattaagagt tattttgtgt ttgtattctt     1740

ggctggatgt tataataaac atattgttac tgtc                                 1774


<210> 4339
<211> 2483
<212> DNA
<213> Homo sapiens

<400> 4339
atcttgcatg ttggctagac tagaaatcaa acaacttgga aatcgatcac aaccaggcat       60

taagttcaca atacctttgt ctggatatgg aggaacaagc aatcttattt tggaaggcgt      120

taaaaaatta tctgacagtt acatggtaac agtgaatggc ttagtacctg gcaaagaaag      180

taaaattgtt ttttctgtcc gcaacactgg ctcccgagca gcttttgtta aagcagtagg      240

ttttaaggat tctcagaaaa aagttttgct ggatcctaaa gtattgagga tttttccaga      300

taaatttgta ctcaaggaaa gaacacaaga aaatgttact ttaatatata atccatcaga      360

cagaggaatc aataataaaa ctgcaacaga actatcaact gtatacttat ttggtggaga      420

tgaaatttca agacagcagt atcgcagggt cattggaatg ttttacaaga gggaatttaa      480

tggcgacttg ctacatgatg ttagaacaga ccaaatacaa agcttgcctt tgaacctggt      540

tttgtttctt aattattttg gaaatagaaa ctgacatttg gagaaatcac attatgaggg      600

ccctgttaca taaaccagag atgataaaac agatacttcc agaacatagt gtgcttcaaa      660

acattaattt tgttgaagca tttcaagatg agctattagt aactgaagta tatgatcttc      720

cccaacgacc taatgatgtt cagctctttt atggaagcat gtgtaaaatt atactttcag      780

taattggaga attcagagat tgcatttcta gcagagaatt ccttcagcct tcttccaaag      840

ctagcttgga atctacaagc gacttgggag cttctgggaa acatggtggc aacgtctctt      900

tggatgtttt accagtcaaa ggtcctcagg gttctcctct tctctcacgg gcggctcgcc      960

cgcctctgga tcagctggcc tccgaagagc cgtggactgt cctacccgag cacttgattc     1020

tggtagctcc ttctccttgt gacatggcaa aaactggacg tttccagatt gtgaataact     1080

ctgtgaggtt actgagattt gagctgtgct ggccagcgca ttgcctcaca gtcacgccgc     1140

agcatggatg tgtcgcgcca gagagtaaac tacaaattct tgtgagtcct aattcctcct     1200

tatccacaaa acagtcaatg ttcccgtgga gtggtttgat ctatatacac tgtgacgatg     1260

gacagaagaa aattgtgaaa gttcaaattc gagaagattt aactcaagtg gaacttttaa     1320

ctcgtttgac ctccaaacca tttggaattc tttccccagt atctgagcct tcagttagtc     1380

atttggtcaa accaatgaca aaaccgcctt ccacaaaagt tgaaataaga aacaagagta     1440

ttacttttcc tacaacagaa cctggtgaaa cttcagagag ctgtctagaa ctcgagaatc     1500

atggcaccac agacgtgaaa tggcatctgt catctttagc gccaccttat gtcaagggag     1560

ttgatgaaag tggagatgtt tttagagcta cctatgcagc attcagatgt tctcctattt     1620

ctggtctgct ggaaagccat gggatccaaa aagtctccat cacatttttg cccagaggta     1680

ggggggatta tgcccagttt tgggatgttg aatgtcaccc tcttaaggag cctcacatga     1740

aacacacgtt gagattccaa ctctctggac aaagcatcga agcagaaaat gagcctgaaa     1800

acgcatgcct ttccacggat tccctcatta aaatagatca tttagttaag ccccgaagac     1860

aagctgtgtc agaggcttct gctcgcatac ctgagcagct tgatgtgact gctcgtggag     1920

tttatgcccc agaggatgtg tacaggttcc ggccgactag tgtgggggaa tcacggacac     1980

ttaaagtcaa tctgcgaaat aattctttta ttacacactc actgaagttt ttgagtccca     2040

gagagccatt ctatgtcaaa cattccaagt actctttgag agcccagcat tacatcaaca     2100

tgcccgtgca gttcaaaccg aagtccgcag gcaaatttga agctttgctt gtcattcaaa     2160

cagatgaagg caagagtatt gctattcgac taattggtga agctcttgga aaaaattaac     2220

tagaatacat ttttgtgtaa agtaaattac ataagttgta ttttgttaac tttatctttc     2280

tacactacaa ttatgctttt gtatatatat tttgtatgat ggatatctat aattgtagat     2340

tttgttttta caagctaata ctgaagactc gactgaaata ttatgtatct agcccatagt     2400

attgtactta acttttacag gtgagaagag agttctgtgt ttgcattgat tatgatattc     2460

tgaataaata tggaatatat ttt                                             2483


<210> 4340
<211> 1991
<212> DNA
<213> Homo sapiens

<400> 4340
agagcggagg cggtggtggt ggcggccgct ggccagttcc ttcagtgaat ctacagacct       60

attttctcag gagctcagcc tggccttact tcagtgataa aaggaggaaa ggctggctac      120

agcaaacatc attcaagatg tccagcaaag ggagcagcac agatggcaga acagacttag      180

ctaatggaag cctgtctagc agtccagagg agatgtctgg agctgaagag gggagggaga      240

catcctcagg cattgaagtg gaggcctcag acctgagttt gagcttgact ggggatgatg      300

gtggccccaa ccgcaccagc atggaggaca ctggtcatta ctccattaat gatgaaaatc      360

gagtccatga ccgctcagag gaagaggaag aggaggaaga agaggaggaa gaagagcagc      420

ctcggcgccg tgtacagcgc aagcgggcta accgtgacca ggactcatca gatgatgagc      480

gggccctaga ggactgggtg tcctcagaaa catcagctct accccgacct cgctggcaag      540

ccctccctgc ccttcgggag cgggagctgg gttcaagtgc ccgctttgtc tatgaggcct      600

gtggggcaag agtctttgtg cagcgtttcc gcctgcagca tgggcttgag ggccatactg      660

gttgtgtcaa taccctgcac tttaaccagc gcggcacctg gctggccagt ggcagcgatg      720

acctgaaggt ggtggtgtgg gattgggtac ggcggcagcc agtactggac tttgagagtg      780

gccacaaaag taatgtgttc caggccaagt ttcttcctaa cagtggtgat tctactctgg      840

ccatgtgtgc ccgtgacggg caggttcgag tagcagaact gtctgccaca cagtgttgca      900

agaatacaaa acgtgtggcc cagcacaagg gagcgtccca caagttggca ctggaaccag      960

actctccctg tacgttctta tctgcaggtg aagatgcagt tgttttcacc attgacctga     1020

gacaagaccg cccagcgtcg aaactggtgg tgacaaaaga gaaagagaag aaagtggggc     1080

tgtatacgat ctatgtgaat cctgccaata cccaccagtt tgcagtgggt ggacgagatc     1140

agtttgtaag gatttatgac cagaggaaaa ttgatgagaa tgagaacaat ggagtactca     1200

agaagttctg tcctcatcac ctggtgaaca gtgagtccaa agcaaacatc acctgtcttg     1260

tgtacagcca cgacggcaca gagctcctgg ccagttacaa tgatgaagac atttacctct     1320

tcaactcctc tcacagtgat ggggcccagt atgttaagag atacaagggc cacagaaata     1380

atgccacagt aaaaggcgtc aatttctatg gccccaagag tgagtttgtg gtgagcggta     1440

gtgactgtgg gcacatcttc ctctgggaga aatcatcctg ccagattatt cagttcatgg     1500

agggggacaa gggaggcgtg gtaaactgtc ttgagcccca ccctcacctg cctgtgctgg     1560

caaccagtgg cctagaccat gatgtgaaga tctgggcacc cacagctgaa gcttccactg     1620

agctgacagg gttaaaagat gtgattaaga agaacaagcg ggagcgggat gaagatagct     1680

tgcaccaaac tgacctgttt gatagtcaca tgctgtggtt ccttatgcat cacctgagac     1740

agagacgcca tcaccggcgc tggcgagaac ctggggttgg ggccacagac gcggactctg     1800

atgagtctcc cagctcctca gacacatcgg acgaggagga gggccctgac cgggtgcagt     1860

gcatgccatc ttgaggcctc atacctaggt ggggcaggct ggggctgcca acctgatcct     1920

gcctgggcaa ccctttcctg tcccaggccc tacattcagc agaaacgcac tttggacttt     1980

ttgctttaga t                                                          1991


<210> 4341
<211> 930
<212> DNA
<213> Homo sapiens

<400> 4341
cgccgggact tcccgcccct tcctgggggc tgcctgacct cggactgtgg ctgggggtgc       60

atgttacgca gcggccagat gatgctggca cagggccttc tgctgcattt cctgcccaga      120

ggaactcctg cgttgcgagc tgtgcctggg catcatgggt gggaaaccgc gacactcact      180

gtacttcatt ggctaccaag atgacttcct gctgtacctg gaccctcact actgccagcc      240

cactgtggat gtcagccagg ccgacttccc cctggagtcc ttccactgca cctcgccccg      300

caagatggcc tttgccaaga tggacccaag ctgtaccgtg ggcttctatg ctggagacag      360

gaaggagttt gagacactct gctcagagct gaccagggtc ctcagctcct cctcagccac      420

agagcggtac cccatgttca ccctggccga gggccatgct caggaccaca gcctggacga      480

cctctgctcc cagctcgccc agcccacact ccggctccct cgcacagggc ggctcctcag      540

ggccaaacgc cccagctctg aggactttgt gtttttataa agggagggga tgaggggaaa      600

gatacaacac tatttatttt tttatttatg tcatgtcggg tgtgggatct tgagctctgg      660

cagtgatgat ggtacttcct gttgtcagcc cctcaagccc agctgcaacc agtctggggc      720

cattcagcca gggacagagc ccacagagcc catacacctg tctcccacca gcggggccct      780

cctggcaggg tagggaagga ggaccccggg cacccccctc agggcctgac tcacgtactg      840

tagtttgcac tggacgcccg ggccctccct gtcccaaagc ccccttgggg gaactgtggc      900

tgctgggggc caataaagct gtgtaacttg                                       930


<210> 4342
<211> 1556
<212> DNA
<213> Homo sapiens

<400> 4342
agaatcagct gtcctctcag actgtgtggg tggtttcccc ggccgcagct ccgtacgggc       60

ttggattgct gggcctcggt gcaccccagc ctcccccact cgggttctga gcttgagctg      120

gcggctcttt aactctgctt cactgttgct cttggcaaca tccacttccg ggagcgagtg      180

ccgtttcccc cgctcaccgc gggctaggga gcgtgggatt ccggactgtg agcggctgtt      240

agtgcgtcgc agctgctggc gatccggcga ccctcggccg gcaggacccg cgggccacgc      300

agccggggcc ttctcaacgc ctcagtacct cggcgggacc gccatggttc tgctgcacgt      360

gaagcggggc gacgagagcc agttcctgct gcaggcgcct gggagtaccg agctggagga      420

gctcacggtg caggtggccc gggtctataa tgggcggctc aaggtgcagc gcctctgctc      480

agctccaaat gagaagatga agcaagtgtt aaagaagact atagaagaag ccaaagcaat      540

aatatctaag aaacaagtgg aagccggtgt ctgtgttacc atggagatgg tgaaagatgc      600

cttggaccag cttcgaggcg cggtgatgat tgtttacccc atggggttgc caccgtatga      660

tcccatccgc atggagtttg aaaataagga agacttgtcg ggaacacagg cagggctcaa      720

cgtcattaaa gaggcagagg cgcagctgtg gtgggcagcc aaggagctga gaagaacgaa      780

gaagctttca gactacgtgg ggaagaatga aaaaaccaaa attatcgcca agattcagca      840

agtaagtact ttttgcttta atgtgtcagt agtttttgtt atttcccttc aaactgataa      900

aaatgtacag tgaatccgaa agatttaaac tactggtaca aatattttaa tcttattggc      960

tcgggtttaa actaaaaata tcctcttcct gcacaccaac aaaaactgga agaaaatatg     1020

gattgagtac caatatctag agtttgtttt aatatgtggg ggagaggaaa tatactatgt     1080

taatttcaag cgtaaaaata gggctgcaag taaacagata tgttccttga aatgtaaaat     1140

ttcgcccgtc actgatttca ggctttttca aactgctgat gctgtgtaca ggagggggag     1200

gaggaaaggt tcgagacctt tgaaggacat cgtgtagcgc tgtaacctga ggggccgcct     1260

tggttttgtg ggtgctccta cgtcactagg ctgtgatttt ggggaaatgg ggccctccac     1320

cttatgtaga tccagagtcc gtggctctga gcatcctccc tttcccactg gacctgcctg     1380

cagtgtctgc cttgggaatg gtcaagacag agatggtatc gtgcagcctc tggtctccac     1440

acagtgagag tccagggctc agggctgctc aagaccaagg cttcccttga tgcttcactt     1500

cgggtgatca gacatggggg acctgtttat ctttagtagc cggcaaaggc aatcgt         1556


<210> 4343
<211> 3305
<212> DNA
<213> Homo sapiens

<400> 4343
tgggcatgtg agtgtggcac acctcctgtt ggatcacggg gctgatgtca atgcccagaa       60

ccggctgggg gccagtgtgc tcactgtggc ttctcggggc ggccacctgg gtgtggtgaa      120

gctgctcctg gaagccggtg cctttgtgga ccatcaccac ccttcaggcg agcaactggg      180

gttgggcggc agcagggatg agcccttgga catcacagcc ctgatggctg ccatccagca      240

cgggcacgag gccgtggtgc gtctactgat ggagtggggc gcggacccca accacgcagc      300

ccggaccgtg ggctggagcc cgctgatgct ggccgcactc actgggcggc ttggagtggc      360

ccagcagctg gtggagaagg gcgccaaccc tgaccacctc agcgtgctgg agaagaccgc      420

cttcgaggtt gcactggact gcaagcacag ggaccttgta gactacctgg acccgctgac      480

caccgtcagg cccaaaacag atgaggagaa aaggcgacct gatattttcc atgcattgaa      540

aatgggaaac ttccagctgg tcaaagagat tgccgatgaa gaccccagcc acgtgaactt      600

ggtcaatggg gacggggcga cgccactgat gctagcagct gttacggggc agctggctct      660

ggtgcagctg ctggtggaga ggcacgcgga tgttgacaag caggacagcg tgcatggctg      720

gacggccctc atgcaggcaa cctaccatgg gaataaggaa attgtgaaat atctgctaaa      780

ccaaggggcc gatgtcactc ttcgtgcaaa aaatggatac acggcctttg acctggtgat      840

gctgctgaat gatcccgaca cggaacttgt tcgactgctg gcatctgtct gcatgcaggt      900

gaataaagac aaaggccggc cgagccacca gcctcccctg ccccactcga aggtccgaca      960

gccctggagc atcccagtgc tgcccgatga caagggtgga ctgaagtcct ggtggaaccg     1020

aatgtccaat cggttccgaa agctcaaact gatgcagacg ctgccccgtg ggctgtccag     1080

caaccagcct ttgcctttct ctgacgagcc tgagccagct ctggactcca caatgagggc     1140

tgccccccag gacaagacaa gccgctctgc actccctgat gcggcccctg tgaccaaaga     1200

caatggtcct gggagcacaa gaggagaaaa ggaagacacg ttattgacaa ccatgcttcg     1260

aaacggagct cccctcacca gactcccgag tgacaagctg aaagcagtca tccccccatt     1320

cctaccccct tccagttttg agctgtggag ctctgatcgg tcccggacgc gtcacaacgg     1380

gaaggcagac cccatgaaga ctgcgctgcc ccagagagcc agcaggggcc accccgtggg     1440

cggcgggggc acagacacta cacccgtcag gcctgttaaa tttccaagcc tccccagaag     1500

cccagcctct tctgccaatt ctggaaactt caaccactcg cctcattcat cgggcggctc     1560

cagtggggta ggtgtgagcc ggcacggtgg ggagctgctt aaccgctcag gtggcagcat     1620

agacaatgtc ttgtcccaaa tcgctgccca gaggaaaaaa gcagccggat tattggagca     1680

gaaacccagc catcggtcaa gccctgtggg gccagcaccg gggtccagcc cgtctgagct     1740

tccagcctcc cctgcaggtg gcagcgctcc tgttggcaag aaattggaga ccagcaaaag     1800

gcctccatct ggaacttcca ctacctccaa gagcacctct ccaaccctca cgccctcccc     1860

ctcacccaaa gggcacactg cagagtcctc agtgtcttcc tcgtcatccc atcggcagtc     1920

caagagcagt gggggctcca gcagtggcac catcacagat gaggatgaac tgactggaat     1980

ccttaagaaa ttatcacttg agaaatatca gcccattttt gaggaacaag aggtggacat     2040

ggaagcgttc ctcacactga ctgacggtga cttgaaggag ctgggaatta agacagatgg     2100

gtccaggcag cagattctgg cagcgatttc tgaactgaac gcaggcaagg gacgcgagag     2160

acaaatttta caggaaacca ttcacaactt tcactcttcc tttgagagca gtgccagcaa     2220

caccagggcc cctggcaaca gcccctgtgc gtgatcctcc ttcccgcagc caccagcgtg     2280

agctctctga atcccgggac cccttcacgt ggccacagcc ccagccctgc ccccgtcaca     2340

ctgctgtgcc ttagtcatgt tgttcccttt gctcgggatg cccacttcac gtcgacggca     2400

ttcattggta gtacttcttg ctgcaacaaa cttcaacaca cagagacaga ttcccatgta     2460

acagtccagt gggggtgctt ctgcttggca ggttggttca cacagtgatg cagggactca     2520

gctcctttca tcctgtgctc tgccctcccc gggagcctca gagtttgctt ctggctggcg     2580

gcaagggaaa gggacgatgg agaaggcacg gctgcttctt acctgccttg ctcttaactg     2640

acacacatca ctcctgctca cgtcctcttg gccactggta gtcatgtggc cccacctgga     2700

tgcagaggag gccaggatgt gcagtctcca catagtggct tcccagcaac aacttttgac     2760

ttagatgggg gccatggttg ggtgggtgag gccagaagaa actgcctccg gcaagaggta     2820

gcagccgctc aggtggctct gctggcatcg gagcccacag aagtgaggag tggccgatgg     2880

acctgccctc caaatgtgcc tgactctggg tcttgctgtc actggatttc ctggcatggc     2940

agacagaaag aaagatagtt tgaccaagtc gtagaagctg atccagcggg taaaaagggg     3000

gcagggaact cgtccctttt attcttgcct cagagctgcc tgaagacatg ggccaggccg     3060

gaggctggac aactttggat aacgctgacc tgtacttcca agtaaatgcc tcctgaagag     3120

cccgggaccc ttcctgggag aattctgcag ccagaatgaa ggtgccatca gcaggaggca     3180

ctgtgaagca ccatcctgtc gctgtccttg tccattccta gcaagttaat cgtgtcttgt     3240

taaccagcag ttcctgttca acgtgtaaag agacctgatg ttttccctaa taaagctgat     3300

aacag                                                                 3305


<210> 4344
<211> 3112
<212> DNA
<213> Homo sapiens

<400> 4344
ctcgggtcag actaccggcg gcgacgacca caggagcatg gcggacaccg acctgttcat       60

ggaatgtgag gaggaggagt tggagccatg gcagaaaatc agtgatgtca ttgaggactc      120

tgtagttgaa gattataatt cagtggataa aactaccaca gctggcaatc ctttggtcca      180

gcaaggtgga cagccactca tcctgaccca gaatccagcc ccaggtctgg gcacaatggt      240

tactcaacca gtattgaggc ctgttcaggt catgcagaat gccaatcatg tgactagttc      300

ccctgtggcc tcacaaccaa tatttatcac tacgcagatt catgaaccat atgaaacacc      360

acgtagaact cgatcagcag aacggtgagg tagatggtca cactatctgc cagcactgtt      420

accgccagtt ttccactccc ttccagcttc agtgccactt ggaaaatgtt catagtccct      480

atgaatctac taccaagtgc aagatctgtg aatgggcgtt tgaaagtgag ccactatttc      540

tccagcatat gaaggatact cataagcctg gagagatgcc ttatgtttgc caggtgtgtc      600

aatatcgctc ctcactctac tctgaggtag atgtccattt tcggatgatc catgaggata      660

cccggcatct gctctgccct tattgcctga aggtcttcaa aaatggcaat gcattccaac      720

agcattacat gaggcaccag aagagaaatg tttatcactg caacaaatgc cggctgcagt      780

ttctctttgc caaggacaaa attgaacaca agcttcaaca ccataaaacc ttccgtaaac      840

ccaagcagct ggagggcttg aaaccaggca ccaaggtgac aatccgggct tcccgagggc      900

agccacgaac tgttcctgta tcctctaatg atacacctcc cagcgccttg caggaggcag      960

caccgctgac ctcctcaatg gaccctctgc ctgtcttcct ttatccccct gtccagcgca     1020

gcatccagaa gagagctgtt aggaaaatga gtgtcatggg ccggcagaca tgcctggagt     1080

gcagcttcga gatcccagac ttccctaatc atttccctac ttacgtacac tgctctctgt     1140

gtcgctatag cacctgctgt tctcgagctt atgccaacca catgatcaac aatcatgttc     1200

cacggaagag ccccaagtat ttggctttgt ttaaaaattc tgtgagtgga atcaagctgg     1260

cctgcacttc atgtaccttt gttacctctg tgggcgatgc tatggccaag catttggtat     1320

tcaacccctc tcacagatcc agcagcatcc tgccacgggg actcacttgg atagctcact     1380

caaggcatgg ccagactcgt gaccgagtgc atgaccggaa cgtgaagaat atgtaccctc     1440

ctccttcctt ccccactaac aaagctgcca ctgtgaaatc tgcgggggcc accccagctg     1500

agcctgaaga gctactaact cccttagccc cagcactccc atcaccagcc tcaactgcaa     1560

ccccaccacc aacccccact cacccgcagg ctttagccct tccaccgctg gctacagagg     1620

gagccgaatg tctgaatgtt gatgatcagg atgaagggag cccagtcacc caagaacctg     1680

agctagcatc aggtggtggt ggtagtggtg gagttggcaa aaaggagcag ctgtctgtga     1740

agaagcttcg agtagtactg tttgctctat gctgcaatac agaacaggca gctgaacact     1800

tccgaaatcc ccagcgacgt attcgccgtt ggcttcgacg tttccaggcc tcccaggggg     1860

agaatctaga gggcaaatat ctgagctttg aggcagaaga gaaactggct gagtgggtgc     1920

taacccagcg cgaacaacag ctacctgtaa atgaggagac cttgttccag aaggccacca     1980

aaataggacg ttctttggaa ggggggttta agatctccta tgagtgggct gtgcgtttca     2040

tgctgcggca ccacctgact ccccatgccc ggcgagctgt ggcccacacc ctacctaagg     2100

atgtagcaga gaatgcagga ctcttcattg attttgtaca acggcagatt cacaaccagg     2160

acttaccctt gtctatgatt gtggctattg atgagatctc tttgttcctg gatacagagg     2220

tgctgagcag tgatgatcga aaggagaatg ccctgcagac agtgggcaca ggggaacctt     2280

ggtgtgatgt agtcctagcc attctggcag atggcactgt ccttcccacc ctggttttct     2340

acagagggca gatggatcag cctgctaaca tgccagactc catattgcta gaggcaaagg     2400

agagtggcta cagtgatgac gagatcatgg agctgtggtc aactcgagtg tggcagaagc     2460

acacagcttg ccagcgcagc aaaggcatgc ttgtgatgga ctgtcatcgc actcacttgt     2520

cagaagaggt actggctatg cttagtgcct ctagcacttt gcctgcagtg gtcccagcag     2580

gctgtagctc caaaattcag ccattagatg tatgcatcaa aagaactgtc aagaacttcc     2640

tgcataaaaa atggaaggaa caggctcggg aaatggcaga tactgcatgt gattctgatg     2700

tcctgcttca gctggtgctt gtctggctgg gtgaagtgct aggtgtcatt ggggactgtc     2760

cagagctagt tcagcgctcc ttcctggtgg ctagtgttct gcctggcccc gatggcaaca     2820

ttaactcacc tacaagaaat gctgacatgc aggaggagct aattgcctcc ctagaggagc     2880

aactgaagct gagtggggaa cattctgagt cttccactcc acgacccaga tcatctcctg     2940

aagagacaat tgagcctgaa agtcttcacc agctctttga gggtgaaagt gagaccgagt     3000

ctttctatgg ctttgaagaa gctgacctag atctgatgga gatttgagtg ttggggtcat     3060

gagggggtgt ggagtgaggg tgggaacatg tgagggaggg taaaggggct ta             3112


<210> 4345
<211> 463
<212> DNA
<213> Homo sapiens

<400> 4345
gtgcggaggc tgagccggcc gcgggcgcga ccggaggcag gcatctgaat ttcatttgaa       60

aatgaaatgg gctgcacagt ctggagaagt gtactatacc ttgttatagc acgttttgga      120

atgacccaga attcagaatg aaatgggcag ctatgagccc catccaaagt ttccgttact      180

atggcaatga cggcagggac tacaacaacc tttcctatga gcaaccatac ccgggaaaga      240

gtgactgtag ccaagctcac attggagaat ttttatagca acctaatttt acagcatgaa      300

gagagagaaa ccaggcagaa gaaattagaa gtggccatgg aagaagaagg attagcagat      360

gaagagaaaa agttacgtcg atcacaacac gctcgcaaag aaacagagtt cttacggctc      420

aaaaggacca gacttggctt ggatgacttt gagtctctga aag                        463


<210> 4346
<211> 5228
<212> DNA
<213> Homo sapiens

<400> 4346
cgagggagga gactcccgtc agtgacttca ttgagtaggt tcttggggat tggggtcggg       60

tcctccccag tgagaggcga caggagctca ctgcctctcg ggccctcaca atcacacctg      120

tcacaggtat acacgctgcc actcacaaac acacgcttgc actcccagcc tcactgacac      180

gctgccatac agccgctcac agccagccag acactgctgc acctgagagc aggtggccgc      240

gggtcttctc ccttcactct ccacatttgg ggatcaggtc cggcacctgc tgcgccagac      300

aggccttgct gggcacgcgc ctctgagagt ccaaggaggt ggcttccaga gctgcagcac      360

ttcaggccgg ctccggtgga gcgatcagag gtgaggggct tggctgggca tgtttaagcg      420

cacagtgctc tcctgcccac ccccagcagc acccccactg caggcccgag gagctttccg      480

gagcttccca cactcctggg gagaagactt cttagccagc ttgatgttta aaattcagct      540

ggagccctta aaacttcgag cgtggacgct gaatgggttt gtaaagtttc ggtaagtccc      600

tccggagaag ggcactcaca cccataccca gtcaaaccct ccacgcggcc atcccctcca      660

ttgccttcct gcttcctcca actcatcctc atcccctctg tgacatacag gaacccccct      720

ccggcctcac ccacatattt gaatgaattg caccccttat cattcctttt ctcaaaccct      780

tcaggtatcc attttccaca gacatttcct ccattatttc aactctccac attcctccct      840

ttcaacccat cattaaccca ttttccacct cagccatttc catctgtcac tcatccccct      900

ccatcagtac ctcattttct gtatcagcca tctcccctcc ctgtacctca acagtccccc      960

tcgccatttt ctccccattt ttccttcctg cctctacctt aacatcctcc tcattcttct     1020

ccatcaaagg cagtgccatg ccatggggct cctttgtcat tccaacacgt ggcctgtggg     1080

taggggggaa gggaaggagg gaggaaagca gaaagagaaa aaggaggcag atcctgaaag     1140

agcttgccct gtgtctgcgg aggcaagaga tgtatgggcc tagagcagct agcaggtggg     1200

taccagggag gaagctggcc gggtgtggag gtaatgcagg gacaccaaaa ggaggtgggt     1260

ggttggtgag ccgttccact ggccctctgc ctggaagctg ctctcgttct ctaggggcac     1320

cctcttggtg tgctagggtt ctttcccagt cccaggggaa agaaggtgtg ggttgaggca     1380

gaaatggcag accacccccc cccgctccct ctcagacggc ttttgctgcc atttccgaaa     1440

acggttgccc ccccccccaa cgaggtgctc tttcttctct gcctctccca accccacccc     1500

ccaccccatc tcccccacag acgtgacatg ctggtggggg gcaatggggg agtacccgcc     1560

tttgtggagc cttttcttcg tcagagaaag gtgactccca gaaccatgag tcaacccagc     1620

cacctgcagc agggcctgtg ggggcagcag tgagggccat tgtccctgcc cacctagggc     1680

cttgggcgcc tcccccttac ccggttacag gcctcactcc tggaaggaca ccctgtacac     1740

ctccctgctg tgaagcagtc agaggcagaa aggcaggtct cagctgtggc tgccagccta     1800

ggacattgct agaaagactc tggttctcct ggctttggca ggggttggcc aagtctcaga     1860

agggctgaga atggcttctg gccatccccc agagagctct agctacagga aagtccccct     1920

tcccctgata tccaccacag acacaccgat agagggagac tggaatggaa gaattcgggt     1980

tgtacgtttc tcttataaca aatgctcctg cacccacctt aaaagggact cagaggaata     2040

tgggtctgat gatgggccgg atcctaaacc acagggtgga ctgggggcgt agggtgaggc     2100

taggagaggt attaaggaaa tggtggttgg ttagtgccca attgtctcct aacagctggg     2160

gttgaaaaag tcctgtcccc aggatgcttt tgttcactca cactggtgct taggcggcac     2220

agccctcaca gttttgtgtg tagacgctgg caaatgagta aagggaactg ttgccctggt     2280

tgggggaagg atagtgtcgc cccccctgct aatgagggag ttggaaacag cagtttccaa     2340

aggctgtgag tcaccctgtg atctgagtca cacgtgaggc ttagcatcgt cagaggggtg     2400

ggggcgggga ggcctggggt ctccgatggc agacaggact ccagacaccc attccctgac     2460

tcagtctggc tggccaggac agctggcgga agacccaggc ctgttcccgg tcctgggcca     2520

ctgccccagc tgccctcagc ctgggcacca tgcctgaggc gtggcgtagg agaccacgat     2580

gctcaggtga cctcacccgt tacactgacc ttcgccagct cctgtgtgtg ggtcgctcag     2640

tccatggtgc cacctcgctc agcagggcct ctcaggggtc ctcagtctgg cccaaggacc     2700

agggcctcag cctagcccca agagtgggcc acaaccttca gcttcctgct gggaaaaccc     2760

aggaggtgag gacggaatca cagaattcta gaatgtcaga gccagaagag atcatctagt     2820

ccaaaccttt cattttacag atggggggac gcaggcccac agaacaggca tgacctgctg     2880

aaggttaccc agggagtcat ttagggattg caagatcatc aggaacaggg ctggggcaga     2940

agagaaggca tcaagtcttg gccctgggtt tctttcagaa acaaggagac cagtgctggt     3000

ccagtggctg tgatgggaaa agattattac aagattcttg ggatcccatc gggggccaac     3060

gaggatgaga tcaagaaagc ctaccggaag atggccttga agtaccaccc agacaagaat     3120

aaagaaccca acgctgagga gaagtttaag gagattgcag aggcctatga tgtgctaagt     3180

gaccccaaga aacggggcct gtatgaccag tatggggagg aaggcctgaa gaccggcggt     3240

ggcacatcag gtggctccag tggctccttt cactacacct ttcatgggga cccccatgcc     3300

acctttgcct ccttctttgg tggctccaac cccttcgata tcttctttgc cagcagccgc     3360

tccactcggc ccttcagtgg ctttgaccca gatgacatgg atgtggatga agatgaggac     3420

ccatttggcg ctttcggccg ttttggcttc aatgggctga gtaggggtcc aaggcgagcc     3480

ccagaaccac tgtaccctcg gcgcaaggtg caggaccccc cagtggtgca cgagctgcgg     3540

gtgtccctgg aggagatcta ccatggctcc accaagcgca tgaagatcac aaggcgtcgc     3600

ctcaaccctg atgggcgaac tgtgcgcacc gaggacaaga tcctgcacat agtcatcaag     3660

cgtggctgga aggaaggcac caagatcacc ttccccaaag aaggcgacgc cacacctgac     3720

aacatccctg ctgacatcgt ctttgtgctc aaagacaagc cccatgcaca cttccgccga     3780

gatggcacca acgtgctcta cagtgccctg atcagcctca aggaggcgct gtgtggctgc     3840

actgtgaaca ttcccactat cgacggccga gtgatccctt tgccctgcaa tgatgtcatc     3900

aagccaggca ccgtgaagag actccgtggg gagggccttc ccttccccaa agtgccaact     3960

cagcgaggag acctcattgt tgagttcaaa gttcgcttcc cagacagatt aacaccacag     4020

acaagacaga tccttaagca gcacctaccc tgttcctagg ctctgcccca gccagtccag     4080

agcctaccac agcaataccc ccaacactca ctccactcaa tgtgcaccca gcttgatgtc     4140

cactggacac tggcaacttt ttctaaaatg caaaaaaaag ccactggttt tcaggaaaat     4200

gttcctgtcc ctgacccctt ttagagctgg gctgcctggg gggagtggga gggaggtggg     4260

gagagctagc ccaggccagg ggtcaatgtt catgtcacta gctttcaatc cagtttccac     4320

tgcagtggct ggagagtgac ctgagtgcta cttgaagata tgtagagatt ccttatccat     4380

gcctgtacat agcatgtcct cctcccctca gctttgctaa taccagtccc ctcccttccc     4440

tttggcttcc tgctgttggg ggtggaaaag actagaaagg acattgcttt ctcagcccca     4500

cccccaggtc cacagtgtcc aaggtaatgg cacacatatt catgcacaag aagcactcac     4560

ctagagctgt ctgtgcctct ctgggagaaa ggagagagga taagaaggga aagttcacaa     4620

cctgtgaaca gggacttgag cacgagacac ttttcatctg gagcaggggg gtgagctcct     4680

cagcagcctc cgtaacagct gccctgccta cacctgcaga gctggaggtt ctgtcctccc     4740

tgctgctctc aggagtgttc aagggtggag ggcagggaat ggggcctgag gtattaaggc     4800

taagaggtgg gggacagggc ccatctacca gccttcatca ggaagggaaa gggctttggg     4860

gtcaggtggc agctattccc caccaagaga ttcagggtca caggtttttc cccacacctc     4920

tgaactcagg gcctagccac ccccaaactt ccaaatccca cttttgtgat atgtgaagct     4980

actcatttct tacccttgga ggctgtgtgg ggaatttcca gcccttttat gcctgtgtga     5040

tcccacccca cccccatagt tgtataaagg tcatagtgaa gaagctgggg gaagactgct     5100

tcagccagat cctggggtgg ggtctttagg ttttctcact ttgacaaccc ccgaatgttt     5160

ttatagtagt ttttttgtat ttttttgtaa tgacagtatt atgtaaaaaa taaagtattt     5220

taaaaata                                                              5228


<210> 4347
<211> 1638
<212> DNA
<213> Homo sapiens

<400> 4347
cgcggctgag cctctttgtc tgagcgcgct cggctttttt ttttttttct ctctccttcc       60

ctgcagcagt ggccggtgtc cagctgccta ctttctgccc ggatctctgg ctcctcatct      120

ctccggtctc cgcagactaa agccctcggg atatgcagca gccatgcctg tgcacacgct      180

gagccccgga gccccgtccg cccccgccct accttgccgc ctgcggacca gggtccctgg      240

ctacctgcta cgggggccgg cagatggtgg agcccggaaa ccgagcgctg tggagcgcct      300

ggaggccgac aaggccaagt acgtcaagag cctgcacgtg gccaacaccc gccaggagcc      360

tgtgcagccc ctgctgtcca aacagccgct ctttagccct gagactcgcc gcacagtgct      420

cacgcccagc cgccgagccc tgcctggccc ctgccgacgg ccccagctgg acctggacat      480

cctcagcagc ctcatcgact tgtgtgacag ccccgtgtcc cctgccgagg ccagccgcac      540

tcctggacgg gccgagggag ccggccgtcc tcccccagcc acccctccgc gaccgccgcc      600

cagtacctct gcggtccgcc gggtggacgt ccgccccctg cccgcctcgc ctgcccggcc      660

ctgcccatca cccggccctg ccgccgcctc cagcccagcc cggccgccgg gtttgcaacg      720

ctccaagtcg gacttgagcg agcgcttttc tagggcagcc gctgatctcg agcgcttttt      780

taacttctgc ggcctggacc cggaggaggc gagagggttg ggtgtggccc acctggcacg      840

ggccagctcg gatatcgtgt ccctggcagg gcccagtgct gggccgggca gctctgaagg      900

gggctgctcc cgccgcagct cggtgactgt tgaggagcgg gcccgggagc gcgttcccta      960

tggcgtgtcg gtggtggagc gcaatgcccg cgtgatcaag tggttgtatg ggctaaggca     1020

ggctcgggag agcccagcag ctgaaggcta ggcgccactg ggcctggaat tcgccacagg     1080

acggatctta cagaggcaag tggtccctgg acctctcttg catccattct ctagacggcc     1140

gtgtcagagg ctccaccctg ttgtgaactt ggtatggagg caaaggctta gaggctggac     1200

cagcattgtt gggcaaggac tgactctcca agggttttgt tcttggcttt ggacacctga     1260

gaaccccctc ctcccctccc ccaatacaag gtttttgaca tgagtgtact cctgcttagt     1320

tcctcttgtg gggctgcatt tgcggtgctt tgccctcccc actgtgagtg aggggccaag     1380

ggatctcctc aatcctgtct ccccagcggc tctgtttcct ccttccttcc ttggcctctg     1440

tcctttgctg acttcctctt ccttacccag cagaactcac cctggggtcg gggcagtggg     1500

gaggggccta tccactgctc ttcctagtcc ttggcagctg gcctaggtgg gcagactata     1560

ggagggactg gttaggagtc tgcattgctt tgacttccct ctccttggtt aataaacaca     1620

aatgcttgtt tctcaagg                                                   1638


<210> 4348
<211> 545
<212> DNA
<213> Homo sapiens

<400> 4348
caacggaccc tacctcttgt agtgattctc ggggccacgg gcaccggcaa atccacgctg       60

gcgttgcagc taggccagcg gctcggcggt gagatcgtca gcgctgactc catgcaggac      120

ctggtcccat tgtcccccct gtctatggct tagaggtatc tgatgtctcg aagtgggaag      180

agtctgttct tgaacctgct cttgaaatcg tgcaaagttt catccagggc cacaagccta      240

cagccactcc aataaagatg ccatacaatg aagctgagaa caagagaagt tatcacctgt      300

gtgacctctg tgatcgaatc atcattgggg atcgcgaatg ggcagcgcac ataaaatcca      360

aatcccactt gaaccaactg aagaaaagaa gaagattgga ctcagatgct gtcaacacca      420

tagaaagtca gagtgtttcc ccagaccata acaaagaacc taaagagaag ggatccccag      480

ggcagaatga tcaagagctg aaatgcagcg tttaagagac atgtccagtg gcctttggaa      540

aggtg                                                                  545


<210> 4349
<211> 545
<212> DNA
<213> Homo sapiens

<400> 4349
acggcagtga ggtgaggctg gtgagagggg aagtggcgac agttcagtca actccctcaa       60

aaccagtctg gccttcacca ggcggagatg ggtggggccg ggaagacggg cgttgacgac      120

agaaggctac ttccggctgt gtttccgtta ctatggcaat gacggcaggg actacaacaa      180

cctttcctat gagcaaccat acccgggaaa gagtgactgt agccaagctc acattggaga      240

atttttatag caacctaatt ttacagcatg aagagagaga aaccaggcag aagaaattag      300

aagtggccat ggaagaagaa ggattagcag atgaagagaa aaagttacgt cgatcacaac      360

acgctcgcaa agaaacagag ttcttacggc tcaaaaggac cagacttggc ttggatgact      420

ttgagtctct gaaagttata ggaagaggag cttttggaga ggtgcggttg gtccagaaga      480

aagatacagg ccatatctat gcaatgaaga tattgagaaa gtctgatatg cttgaaaaag      540

agcag                                                                  545


<210> 4350
<211> 585
<212> DNA
<213> Homo sapiens

<400> 4350
gttttaaaag attataagta aatactctgc tctttcaagt gaaccaaacc tatcaaacct       60

gtttagaaaa taaaccaggc agaataaaat gatgcgaaat gttcatttta aaaaacttca      120

ggatgggcac aaacacacag aagtgggaaa tgaataaaag agtattgata aatttttgaa      180

aattgttgaa gctgagtaat gggctttcag tccagtgtaa agctgttgga gcgcgggagc      240

aaaggtaaag aatgatgtaa tgcgctggct gctccaaagc atcttttgtt gtggaatggt      300

tattccagtc atctctttat gaatcaaatg tgaggggctg ctttgtggac ggagtccttt      360

gcaagagcac atcaacggga aagagaaaga gacattcact tggagggctc ttgctgaaaa      420

tgggtttaac tctccttttg ccagtcacca ccagcctgac ctcatacact tttagtacaa      480

tggagtggct gagcctttga gcacaccacc attacatcat cgtggcaaat taaagaagga      540

ggtgggaaaa gaggacttat tgttgtcatg gcccatgaga tgatt                      585


<210> 4351
<211> 2674
<212> DNA
<213> Homo sapiens

<400> 4351
agttcacccg cggcggaggg taactttgct gtgctgtttt ttgagcagtt gtctggtccc       60

tggaagtgta gcatcgagag agttttctaa ttacgtttac aaaatatctt ccctttggcc      120

atacaagtgg tgactgccat gtcgaactcg cggcccaggt cccgccgaga cgccgggggt      180

ggcgctgggg cagccggccg ggacgagctg gtgtcgcggt ccttgcagag cgcagagcac      240

tgtctgggcg tccaggactt cggcactgcc tatgcccact acctcctcgt gctcagcctg      300

gcgccggagc tgaaacacga cgtgaagaat gggctttagg gatgaagcag ctgggtattt      360

tcataaagca gtgaagctaa accctgattt cagtgatgca aaggagaatt tttatcgtgt      420

tgcaaactgg ttggtggaac gctggcactt tatcatgctt aatgacacca agaggaatac      480

aatttataat gcagcaatcc aaaaggcagt ttgtttgggg tccaaaagtg ttttggacat      540

tggagcagga actggaatac taagcatgtt tgctaaaaaa gctggagcac attccgtgta      600

tgcctgtgag ttatccaaga ccatgtatga acttgcctgt gatgtcgtgg cagcaaacaa      660

gatggaagca gggatcaaac tcttacatac gaagtcactt gacatagaga ttccaaaaca      720

tattcccgaa agagtgtccc tagttgtaac agaaactgtc gatgcaggtt tatttggaga      780

aggaattgtg gagagtttga ttcatgcatg ggagcattta cttttacagc caaagaccaa      840

aggtgaaagt gctaattgtg aaaagtatgg gaaagttata ccagcaagtg ctgttatatt      900

tgggatggca gtagaatgtg cagagataag aagacatcat agagtgggta ttaaggacat      960

tgctggtatc catttgccaa caaatgtgaa atttcagagt ccggcttatt cttctgtaga     1020

tactgaagaa acaattgaac cttatacaac tgaaaagatg agtcgagttc ctggaggata     1080

tttggctttg acagagtgct ttgaaattat gacagtagat ttcaacaacc ttcaggaatt     1140

aaaaagtctt gcaactaaaa agcctgataa gattggtatt cctgttatta aagaaggcat     1200

actagatgct attatggttt ggtttgtgct ccagcttgat gatgaacata gtttatccac     1260

aagtcctagt gaggaaacat gttgggaaca ggctgtctac cccgtacagg accttgcaga     1320

ctactggata aagcctggag accatgtgat gatggaagta tcttgtcaag actgttactt     1380

aagaatccag agtattagtg tcttgggttt ggaatgtgaa atggatgttg caaaaagttt     1440

tacccagaat aaagacttgt tatcgttagg aaatgaggct gaactttgta gtgccctcgc     1500

taaccttcag accagtaaac cagatgctgt agagcagaca tgtatattgg aatctacaga     1560

aattgctttg cttaacaaca tcccatatca tgaaggcttt aaaatggcaa tgagcaaagt     1620

tttgtcttca ctgactccag agaaactgta tcagaccatg gatactcact gtcagaatga     1680

gatgagctct ggaactggac agagtaatac tgtacagaac atccttgaac ctttctacgt     1740

gttagatgtg tccgaaggct tctctgttct gcctgttatt gctggcacac ttgggcaggt     1800

taaaccatac agttctgtgg agaaagacca gcatcgtatt gctctggacc tcatatctga     1860

agccaatcac tttcctaaag aaacacttga gttttggctg agacatgtgg aggatgaatc     1920

tgctatgtta caaaggccaa aatcagacaa gttatggagc ataattatat tggatgtcat     1980

tgagccatct gggctcattc agcaggaaat aatggaaaaa gctgcaatat ccaggtgttt     2040

actacaatct ggaggcaaga tctttcctca gtatgtgctg atgtttgggt tgcttgtgga     2100

atcacagaca ctcctagagg agaatgctgt tcaaggaaca gaacgtactc ttggattaaa     2160

tatagcacct tttattaacc agtttcaggt acctatacgt gtatttttgg acctatcctc     2220

attgccctgt atacctttaa gcaagccagt ggaactctta agactagatt taatgactcc     2280

gtatttgaac acctctaaca gagaagtaaa ggtatacgtt tgtaaatctg gaagactgac     2340

tgctattcca ttttggtatc atatgtacct tgatgaagag attaggttgg atacttcaag     2400

tgaagcctcc cactggaaac aagctgcagt tgttttagat aatcccatcc aggttgaaat     2460

gggagaggaa cttgtactca gcattcagca tcacaaaagc aatgtcagca tcacagtaaa     2520

gcaatgaaga gcagttttcc aatgaaaact gtgtaaatag agcatcaaca agtacaaaat     2580

tcttgtctta attagtgggg gtatataaaa attccttgta atggtcaaat attttttaaa     2640

attgacatta ataaagcata ttttaaaaga ttct                                 2674


<210> 4352
<211> 1701
<212> DNA
<213> Homo sapiens

<400> 4352
aacccggtcc ccgcccccag acacgccggg ctctcggggc accacagcca tgtgctcgtt       60

agcgtcaggc gctaccggcg gccggggcgc tgtggagaat gaggaggacc tgccagaact      120

gtcggacagc ggggacgagg ccgcctggga ggatgaggac gatgcagatc tcccccacgg      180

caagcagcag accccctgcc tgttctgtaa caggttattc acatctgctg aagaaacatt      240

ttcacactgt aagtctgagc atcagtttaa tattgacagc atggttcata aacatggact      300

tgaattttat ggatacatta agctaataaa ttttattaga cttaagaatc ctacagttga      360

gtacatgaat tccatataca acccagtgcc ttgggagaaa gaagagtatt tgaagccagt      420

attagaagat gaccttttac ttcaatttga tgtagaagat ctttatgaac cggtgtcagt      480

acccttctca taccccaatg gactcagtga aaatacatct gttgttgaaa aattgaaaca      540

tatggaagcc agggcactgt ctgctgaagc cgcattggcc agagcacgtg aggatctgca      600

aaaaatgaaa caatttgctc aggattttgt gatgcacaca gatgtcagaa cctgctcgtc      660

atctactagt gtcattgcgg acctccagga ggatgaggat ggtgtttatt tcagctcata      720

cgggcattat gggatacatg aagaaatgct aaaggacaaa atacgaacag aaagctaccg      780

agatttcata taccaaaatc cacatatctt caaagacaag gtagttttgg atgttgggtg      840

tggaactgga attctctcta tgtttgctgc taaagctggg gcgaagaagg ttcttggagt      900

tgatcaatct gaaatacttt accaggcaat ggatattata agactaaata aacttgaaga      960

tactattaca ctaattaaag gaaagattga agaagttcat cttcctgtag aaaaagtaga     1020

tgttatcata tctgagtgga tgggctattt tcttctgttt gagtctatgt tagattctgt     1080

cctttatgca aagaacaaat acttggcaaa aggaggctcg gtctaccctg acatttgcac     1140

tatcagcctt gtagcagtga gtgatgtgaa taaacatgct gatagaattg ctttttggga     1200

tgatgtctat ggcttcaaga tgtcctgcat gaagaaagca gttattccag aagctgttgt     1260

ggaagtttta gatccgaaga ctcttatttc agaaccttgt ggtattaagc atatagattg     1320

ccatacgacg tctatctcag atttggaatt ttcatcagat tttaccctga aaatcacaag     1380

gacatccatg tgcacggcaa ttgctggcta ctttgatata tattttgaga agaattgcca     1440

caacagggtc gtgttctcta cgggccctca gagcaccaaa acacactgga aacaaacagt     1500

atttctactg gaaaaaccat tttcagttaa agcaggtgaa gccttgaaag gaaaggtcac     1560

agttcacaag aataagagag aagttctcat tgtgggaatc tgacatagtt cagctgagga     1620

agagaatcag ctgatcctca tggtctgcca cgtaatcatt ttcttagacg tttgctccac     1680

cagatttaac caaatgtaac t                                               1701


<210> 4353
<211> 1980
<212> DNA
<213> Homo sapiens

<400> 4353
caacagaaac atgatgctga tgttcagaag attttagaaa gaaagaataa tgaaatagaa       60

gaactgaaaa ctttatacag gagtaaacaa catgaaactg aagagactat tagaaagctt      120

gaaaagaaag ttcagacact gatacgtgac tgtcaagtta tcagagagac taaagaagac      180

cagattgcag agctgaaaaa gatatgtgaa caaagtacgg aatctctaaa taatgactgg      240

gaaaaaaagc ttcacaatgc tgtagcagaa atggaacagg aaaagtttga tcttcaaaag      300

caacacactg aaaacattca agaattgctt gaggatacaa atgtgcgtct gaataaaatg      360

gagagtgaat acatggcgca aacacagtcc acaaaccaca tgatcaaaga actggaggcc      420

cgtgtccagc agctgactgg agaagcagag aacagtaatt tacagaggca gaaattaatt      480

caagaaaaag cagaacttga aagatgttac cagataacgt gtagtgaatt acaagaagta      540

aaggcaaggc gtaacacact gcataaagag aaggaccatc ttgtaaatga ttatgagcaa      600

aacatgaaac tgttacaaac caaatatgat gctgatataa accttctaaa acaagaacat      660

gctctttcag cttctaaggc atctagtatg attgaagaat tagagcagaa tgtctgtcaa      720

ttaaaacagc agttacagga atcagaactt caaagaaagc aacaactaag ggatcaagaa      780

aataagtttc agatggagaa aagtcattta aaacacatct atgaaaaaaa ggctcatgac      840

ttgcagagtg aacttgataa aggaaaagaa gatactcaaa agaaaattca taaatttgag      900

gaagctttga aggaaaaaga ggagcagcta actcgtgtga ctgaagttca gaggttgcag      960

gcccagcagg cagatgccgc tctggaagag tttaagcggc aggtggaact gaactcagag     1020

aaagtctatg ctgaaatgaa agagcagatg gaaaaagtgg aggcagatct aactagatcc     1080

aaatctcttc gtgagaaaca atcaaaggag tttttatggc aactggagga catcagacag     1140

cggtatgaac aacagatagt agagctgaag ctggagcatg aacaggagaa gacgcaccta     1200

ttacagcagc ataacgcaga gaaggatagc ctagtccgag accatgaacg ggaaattgaa     1260

aacctggaaa aacagcttcg cgctgccaat atggagcacg aaaatcaaat tcaggagttc     1320

aagaaacgag atgcacaggt tattgccgac atggaggccc aggttcacaa gttgagagaa     1380

gaattgatca atgtgaactc acagcggaaa cagcagctgg tagagcttgg tcttcttcgt     1440

gaagaggaaa agcaaagggc tacaagggaa catgagattg tcgtcaataa actgaaggct     1500

gaatcagaaa agatgaaaat agagctgaaa aagactcatg ctgctgagac agagatgaca     1560

ctggaaaagg ttttacaaga tgaattagaa aaccgttcta atcaggtgcg atgtgcagag     1620

aaaaaattac aacacaaaga attggagtca caggaacaga taacttacat acgacaagaa     1680

tatgaaacaa aattgaaagg attgatgcca gcatccctaa gacaagaact tgaagacacc     1740

atttcctccc taaaatcaca ggttaatttt ctgcaaaaga gagcttccat ccttcaggaa     1800

gaactgacta catatcaagg cagaaggtaa ctgcacgaga gaatgcaacg gatgcaattt     1860

ccaggctgtg ctgtggactt cttccagcag gtttgaagat ttggatattg taaactgtga     1920

gatcagtggc attttttaaa tccttaaatg taattaagat cataaaaaca tgcatcattc     1980


<210> 4354
<211> 4737
<212> DNA
<213> Homo sapiens

<400> 4354
gtttgaagaa aaactgtcac tgaagagtca tggtggggcc cgggcctacc gctgctgccg       60

ctgtcgaaga gcggcagaga aagcttcagg agtaccttgc agccaaggga aaactgaaga      120

gccaaaacac caagccttat ctaaaatcca agaataattg ccagaatcaa ccaccttcta      180

aatctactat tagacccaaa aatgatgtta ccaaccatgt tgttttgcct gtcaaaccta      240

aaaggtccat cagcattaaa ctccagccca gaccacctaa tactgcaggg tcccagaagc      300

cgaagttgga gccaccaaaa cttctgggca aaaggctgac ttcagaatgt gtttcttcta      360

acccatactc taagccttct agcaagagtt ttcaacagtg tgaagctgga tcgtccacaa      420

caggagaact gtcaagaaaa cctgtggggt cacttaatat agagcaattg aaaactacaa      480

agcagcagtt aacagatcaa ggaaatggta aatgtataga ctttatgaat aatatccatg      540

ttgaaaacga atctttggat aactttctaa aagaaacaaa caaagagaac ttgctcgata      600

tcttaacaga acctgagagg aagccagatc ctaaattata taccagaagt aagccaaaga      660

ctgactctta taatcaaacc aagaacagtt tagttcctaa acaagccttg ggcaaaagtt      720

cagttaatag tgctgttctg aaagataggg ttaataaaca atttgttgga gaaacacaaa      780

gcaggacttt cccagtaaaa tcacagcaac tctctagagg agcagatctt gcaagaccag      840

gagtaaaacc ctcaaggacg gttccctctc actttattcg gacccttagt aaagttcagt      900

catcaaagaa accagtagtc aagaacatca aagatataaa ggttaatagg agtcaatatg      960

aaagaccaaa tgaaactaag atacggtcat accctgttac tgaacagaga gtgaagcaca     1020

ccaaacccag aacatacccc agtttgcttc agggtgaata taacaacaga catccaaaca     1080

tcaagcaaga tcagaagtcc agccaagttt gtatacctca gacatcatgt gtactgcaaa     1140

agtcaaaagc cataagccag aggcctaatt tgacagttgg cagatttaat tcagccattc     1200

caagcacccc tagcataaga ccaaatggaa ccagtggtaa taaacataac aataatggct     1260

ttcagcaaaa agcacagact ttggactcca agttgaaaaa ggctgttccc cagaaccatt     1320

ttctgaacaa gacagctccc aaaactcaag ctgatgtcac aaccgtaaat gggacccaaa     1380

caaacccaaa tattaaaaag aaggcaacag cagaggatcg aaggaaacaa ctagaagaat     1440

ggcagaaatc taagggaaaa acctataaac ggcctcctat ggaacttaaa acaaaaagaa     1500

aagtaataaa ggaaatgaat atttcattct ggaagagcat tgaaaaagaa gaggaagaaa     1560

agaaagcaca actcgaactg tccagtaaaa ttaacaacac tctgacagaa tgtctgaacc     1620

tcatcgaagg gggtgtacct tctaatgaaa tacttaacat attgtccagc attcctgaag     1680

ctgaaaaatt tgctaaattc tggatctgca aagcaaagtt gttggcaagt aaaggcacct     1740

ttgatgttat tgggctatat gaagaggcca ttaaaaatgg ggcaacacca atacaagagt     1800

tgcggaaagt tgttcttaat atcttgcaag actcaaacag aaccacagaa gggattactt     1860

ctgactcttt agttgctgaa actagtataa catcagtgga agagctggcc aagaagatgg     1920

aatctgtgaa gtcttgtctt tctccaaaag agagggaaca agtcacggcg acaccccgaa     1980

tagccaaggc agaacagcat aattatcctg gtatcaaatt acagattggt ccaatcccta     2040

gaataaatgg gatgccggaa gtgcaagaca tgaaatttat cactcctgta cggcgttcgt     2100

cgaggattga gcgagcagtg tcccgctacc cagaaatgct gcaggaacac gatttagtag     2160

tggcttctct tgatgaactg ttagaagtgg aagaaacaaa atgttttata ttccgtagaa     2220

atgaggcgct gcctgtaaca ttggggtttc aaacccctga atcataattt cttgatgctt     2280

tttttaaaaa aggtgtttca gaaccaacat aagacaagaa atattcttgt ccaagtgacc     2340

tggaaaaaaa gagaggcatc atggatgcag attatggacg ctcaggactt aagtaattca     2400

ctgggcttac tctcaaattt tctctcccca tgggaaaatc tttgctttat gtgtttaaga     2460

ccagtttgcc agttttacag tatacataaa tttcaaactt ttgaatattt accctacaac     2520

tatgataaat atttatactt tattgatcta ctttaatccc aacatagttt tttatatcag     2580

aaggttggtc ccacaatata atgggacttt tctttctgca tccaccttag cagagggcaa     2640

gttctttcat cgtggaagat ctgaactttg acgctagctt gacaggctga atggaccttg     2700

acagatggcc aagtcaaaac ccctcatttt acagatgagt ttatgctagc tgtgcctttg     2760

ctcagagatc ataaatttat gtgtgatctt tgactttcat cacagtatcc ttgtaaatga     2820

gagagaattc ttgttttttc tatgccaggt ctcctcagat gaaacacaat cctgaattgg     2880

catggtcgtc tagcttttat attcaaacct agttttgcat ttgttactca gaaacacttc     2940

aagtaacaaa aggggggcag gggagagggg tggggagtgg acacttgctt cttcagttct     3000

ttgctcagct agggtatagc tggcctgaga aggcagtgca agccccagag actgttgtag     3060

gttgcttttt cttcctcctg ggcaactatt tgtggaaagg ttttacctta gtcattatgt     3120

aaatataatt gtgtagaaaa acctagtcaa cacattttaa attttagctt tcttaatatt     3180

taagtattat cttaaaacaa cattaaattt ctattagttc ctgcttgttt atcttattta     3240

ttatagaaaa ccatgataat ggctttgcat agagaattag gagtttgtct aaggatatac     3300

cagttggctg tcctaagaaa caaggagcat tcattaccaa ggagaatgga ctttgatcaa     3360

aggtctatca gcctcatcca ggaactagat ttttttaagg gaagcagatc tatttctgaa     3420

agtcagattt ataataaagc tcaaaaaact gagctataaa cctgtaatac cagcagactt     3480

tcaataagag actcttacaa ctcaattgtg gaaaaactaa taattaaaaa tgggcaaagg     3540

acctgagcag acatttctcc aaagaagaca taagaaatgg ccagtaggta tagatatgaa     3600

aaggtgttca gcatcattaa tcataagaat aatgtaaatt aaaaccactg tgagctatca     3660

cctcacatct ataagaatgg ctattaacaa gacatgagat aaatgttgat gagattgtgg     3720

agaaaagaga accctagtac actgtttgtg ggcgtgtaga ctggggcagc cgttatggaa     3780

aacggtatgg aggctcctaa agaaattaaa aatagaactg ttatctgacc ctcttctgag     3840

taagtatgta cccaaagaag atgaaatcac cagctgggcg cagtgactca cacctgtaat     3900

cccagcactt tggagtgggt gaatcacctg aggtcaggag ttcaagacca gcttgaccaa     3960

catggtgaaa ccccgtctct actaaaaata caaaaagtag gcgggcatgg tgacgggcac     4020

ctgtaatccc agctacttgg gaggctgagg cagaagaatc acttgaactc gggaggtgga     4080

ggttgcagtg agccaaaatt gcgtcactgc actccagcct gggttacaga gcaagactcc     4140

atctcaaaaa aaaaaaagat gaaatcatca cctcataaag atatctgcac tcacatgttt     4200

gtggcagtgt tattctcaat agccaagatg tggaaacaac ctaaatgccc atcaatggac     4260

aaataaagaa aatacggcat atgcatgccg tggaatagta ttcatccttg gaaaagaggg     4320

agttcttgcc atttgccaca acatagatgg acctggagaa cattatgcta agtgaaataa     4380

gccagaccca aggaaaaata ctgcatgatc tcacatatgg aatatttaat tttttaagaa     4440

agagctcaag tacacagaga aagtgcttac cacagattgg ggaagaggaa atggggagat     4500

gcaggccaag gatacaaaat agcagataaa atgaacaagt ctagagatag ggctaaagtt     4560

aatacaattg tattagggat ttttgttaaa taagtagatt ttagctgcta ttatcacaaa     4620

aaaactgaga tgataatgtt aatctgcttc actatagcag ccattttatt atctatatgt     4680

atcccataac atcatgttgt aaatcttaaa tatacctaat aaaataaaat tgtcacc        4737


<210> 4355
<211> 1092
<212> DNA
<213> Homo sapiens

<400> 4355
ggcccgtttg gaagcggcag ccaggacaac ctgactatgt acatggattt agtggacggc       60

atctttttga accaaattat gctgcaaata gatcccaggc ccacaaatca acgcatcaat      120

aagcacgtca acaatgatgt gaaccttcgc attcagaatt tgaccatctt ggtgagaaac      180

attaagacct actaccagga agttctccag cagctgattg taatgaattt gcccaatgtt      240

ttgatgattg gcagagaccc actgtctggg aagagcatgg aggaaatcaa gaaggtgctg      300

ctgctggtgc tgggctgtgc tgtccagtgt gagaggaaag aggagttcat tgaaagaatc      360

aaacagctgg acattgagac ccaggctggc atcgtggccc atatccagga ggtgactcac      420

aaccaagaga acgtgtttga cctgcagtgg ctggagctgc ccgacgtggc tccggaggag      480

ctggaggccc tgtcgaggag catggtgctc cacctgcgga ggctcatcga ccagcgggac      540

gagtgcaccg agctgatcgt ggacctcact caggaacggg actacctgca ggcacagcat      600

ccacccagcc ccatcaagtc ctccagcgcc gactccactc ccagccccac cagcagcctc      660

tctagcgaag acaagcagca cctggccgta gagctggccg acaccaaggc caggctgcgg      720

cgcgtcaggc aggagctgtg agtccccggc tgcttctcct acctttgtgt gtgttgcaga      780

catgtttctg gtgtggtgtc gactcacatg tgtggtgctg ccaatggcac agctctgacg      840

tgtgccccgg agtcagctgg ggtctgccct gagcttactc tttgacctcg gactagctgc      900

ctcccctcca gacggtgcaa gttgtccaca gaagcagcct ccagtccacg ctcagctcca      960

gcttggggcc gggacgacca cacctgatgt gttttcttgg ctggagggat gaggtgcccc     1020

tccttccctc caatctggtg agcctgttct cccaggtttc ctgcagctga tggatgtcac     1080

ctgtggagcc tg                                                         1092


<210> 4356
<211> 1894
<212> DNA
<213> Homo sapiens

<400> 4356
atcaaagaca gcagactttt ctgtgatcca acatttctgc ctgagaatga ttctcttttc       60

tacaaccgac tgcttcctgg aaaggtggtg tggaaacgtc cccaggacat ctgtgatgac      120

ccccatctga ttgtgggcaa cattagcaac caccagctga cccaagggag actggggcac      180

aagccaatgg tttctgcatt ttcctgtttg gctgttcagg agtctcattg gacaaagaca      240

attcccaacc ataaggaaca ggaatgggac cctcaaaaaa cagaaaaata cgctgggata      300

tttcactttc gtttctggca ttttggagaa tggactgaag tggtgattga tgacttgttg      360

cccaccatta acggagatct ggtcttctct ttctccactt ccatgaatga gttttggaat      420

gctctgctgg aaaaagctta tgcaaatctc ccaatcagga ggagcaagaa gttgaaactg      480

attggggtct gctgaagggc catacctata ccatgactga tattcgcaaa attcgtcttg      540

gagagagact tgtggaagtc ttcagtgctg agaaggtgta tatggttcgc ctgagaaacc      600

ccttgggaag acaggaatgg agtggcccct ggagtgaaat ttctgaagag tggcagcaac      660

tgactgcatc agatcgcaag aacctggggc ttgttatgtc tgatgatgga gagttttgga      720

tgagcttgga ggacttttgc cgcaactttc acaaactgaa tgtctgccgc aatgtgaaca      780

accctatttt tggccgaaag gagctggaat cggtgttggg atgctggact gtggatgatg      840

atcccctgat gaaccgctca ggaggctgct ataacaaccg tgataccttc ctgcagaatc      900

cccagtacat cttcactgtg cctgaggatg ggcacaaggt cattatgtca ctgcagcaga      960

aggacctgcg cacttaccgc cgaatgggaa gacctgacaa ttacatcatt ggctttgagc     1020

tcttcaaggt ggagatgaac cgcaaattcc gcctccacca cctctacatc caggagcgtg     1080

ctgggacttc cacctatatt gacacccgca cagtgtttct gagcaagtac ctgaagaagg     1140

gcaactatgt gcttgtccca accatgttcc agcatggtcg caccagcgag tttctcctga     1200

gaatcttctc tgaagtgcct gtccagctca gggaactgac tctggacatg cccaaaatgt     1260

cctgctggaa cctggctcgt ggctacccga aagtagttac tcagatcact gttcacagtg     1320

ctgaggacct ggagaagaag tatgccaatg aaactgtaaa cccatatttg gtcatcaaat     1380

gtggaaagga ggaagtccgt tctcctgtcc agaagaatac agttcatgcc atttttgaca     1440

cccaggccat tttctacaga aggaccactg acattcctat tatagtacag gtctggaaca     1500

gccgaaaatt ctgtgatcag ttcttggggc aggttactct ggatgctgac cccagcgact     1560

gccgtgatct gaagtctctg tacctgcgta agaagggtgg tccaactgcc aaagtcaagc     1620

aaggccacat cagcttcaag gttatttcca gcgatgatct cactgagctc taaatctgca     1680

atcccagaga atcctgacaa agcgtgccac ccttttattt tccgtcaggt gccaggtctt     1740

agttaagatt cacaatcttt agaaagaatg agattcacaa taattaactc ttcctctctt     1800

ctgataaatt ccccatacct cccaatccaa gtagcatctg tagctacata acctatatac     1860

ctccagcagc tggacatggg gaggcgacag tcct                                 1894


<210> 4357
<211> 1538
<212> DNA
<213> Homo sapiens

<400> 4357
cttcctttct cttcccattg tccccaggtc cactgaaaag ggcaagcacc ctgtaaatga       60

gtttccctcc tgctcttgct gggtggagga gataggcaga ggtttagccc ttaaaaagac      120

atggctagga tatccagccc tagtggcctg agaatacagc aagatgacgg agctgtcatt      180

gcaaaaggag cagctgcagc tcaagatcat tgagattgag gatgaagctg agaagtggca      240

gaaggagaag gaccgcatca agagcttcac caccaatgag aaggccatcc tggagcagaa      300

cttccgggac ctggtgcggg acctggagaa gcaaaaggag gaagtgaggg ctgcgctgga      360

gcagcgggag caggatgctg tggaccaagt gaaggtgatc atggatgctc tggatgagag      420

agccaaggtg ctgcatgagg acaagcagac ccgggagcag ctgcatagca tcagcgactc      480

tgtgttgttt ctgcaggaat ttggtgcatt gatgagcaat tactctctcc ccccacccct      540

gcccacctat catgtcctgc tggaggggga gggcctggga cagtcactag gcaacttcaa      600

ggacgacctg ctcaatgtat gcatgcgcca cgttgagaag atgtgcaagg cggacctgag      660

ccgtaacttc attgagagga accacatgga gaacggtggt gaccatcgct atgtgaacaa      720

ctacacgaac agcttcgggg gtgagtggag tgcaccggac accatgaaga gatactccat      780

gtacctgaca cccaaaggtg gggtccggac atcataccag ccctcgtctc ctggccgctt      840

caccaaggag accacccaga agaatttcaa caatctctat ggcaccaaag gtaactacac      900

ctcccgggtc tgggagtact cctccagcat tcagaactct gacaatgacc tgcccgtcgt      960

ccaaggcagc tcctccttct ccctgaaagg ctatccctcc ctcatgcgga gccaaagccc     1020

caaggcccag ccccagactt ggaaatctgg caagcagact atgctgtctc actaccggcc     1080

attctacgtc aacaaaggca acgggattgg gtccaacgaa gccccatgag ctcctggcgg     1140

aaggaacgag gcgccacacc cctgctcttc ctcctgaccc tgctgctctt gccttctaag     1200

ctactgtgct tgtctgggtg ggagggagcc tggtcctgca cctgccctct gcagccctct     1260

gccagcctct tgggggcagt tccggcctct ccgacttccc cactggccac actccattca     1320

gactcctttc ctgccttgtg acctcagatg gtcaccatca ttcctgtgct cagaggccaa     1380

cccatcacag gggtgagata ggttggggcc tgccctaacc cgccagcctc ctcctctcgg     1440

gctggatctg ggggctagca gtgagtaccc gcatggtatc agcctgcctc tcccgcccac     1500

gccctgctgt ctccaggcct atagacgttt ctctccaa                             1538


<210> 4358
<211> 1392
<212> DNA
<213> Homo sapiens

<400> 4358
gcagacggtt ccgggagccg cacggtcccc tctccttccc catcctctcc cctcccctct       60

ccgggttccc ccacccacag gagccttggg ccgaccactc ccccgatggc ctcagccacg      120

gaggaccccg ttctggagcg ttatttcaaa ggccacaaag ctgcgatcac ctccttggac      180

ctcagcccca acggcaagca acttggagag gaaaattctc agaatttaaa gctcatacag      240

ctccagttcg aagtgtagac ttttcagctg atggccagtt tctagctaca gcttctgaag      300

acaaatccat aaaagtatgg agcatgtatc gccagcgctt cctgtattcc ttgtatcgac      360

atacacactg ggtacgctgt gccaaatttt cacccgatgg aagactaatt gtgtcatgta      420

gtgaggataa aactattaaa atttgggata ccacaaataa gcaatgtgtt aataacttct      480

cagattccgt tggatttgca aattttgtgg actttaaccc tagtggtaca tgcatagctt      540

cagcaggttc tgatcaaact gtgaaagtct gggatgtaag agtgaacaaa ttactacagc      600

attaccaagt tcacagcggt ggagttaatt gcatatcatt ccatccttcg ggtaactatc      660

tcatcacagc ttcttcagat ggtaccctta agattctgga cctcttagaa ggaaggctca      720

tctatacact tcaaggacat acgggacctg tctttactgt ttcattttca aaaggtggag      780

agctatttgc atcaggaggt gcagacacac aggtcttatt atggaggact aactttgatg      840

aattgcattg taaaggtctt accaaaagaa atctcaaaag attacatttt gattcaccac      900

cacatcttct tgatatctac ccaagaacac cacatcccca tgaggaaaaa gttgagactg      960

tagaagattt ttttcttcat cttttgagat taatccaaag cttgaggtaa tcgatttgca     1020

gatctctact ccccctgtta tggatatcct ttcttttgat tctaccacaa caacagaaac     1080

cagtggtagg actctgccag acaagggtga agaggcctgt ggatatttct tgaacccttc     1140

cttaatgtca ccagaatgtt tgccaacaac cacgaaaaag aaaacagaag acatgagtga     1200

cctcccctgt gaaagtcaaa ggagcatacc tctcgctgtg actgatgctt tagagcatat     1260

tatggaacaa ctcaatgttt tgacacagac tgtttcaatc ttggagcagc gactgacttt     1320

gacagaggat aagctgaaag actgccttga aaatcagcaa aagcttttca gtgctgtcca     1380

acagaaaagc tg                                                         1392


<210> 4359
<211> 2469
<212> DNA
<213> Homo sapiens

<400> 4359
gcgacgccga gtttcactct ggctgccttc tcctgagagt cggagccaca gccagagccc       60

tgcccaggcc gagccggagc tgcagcccga gcgcggtggt gccctcagcc ccgtcctctt      120

gtcctcctca gcctcggtgc cttggaattt gtgtcgctga gtcagcaagc ctttcagatt      180

tgcccggttt ttgttgtttg tggtttgtat caagatggga actcaaacaa gtcattcctc      240

ctaaggagct ggtgtcttca tccagaaggg acagtttgtg ccagctctcc agagagaaaa      300

ggatctggta ctgttctgga gtggcctgta gcagacactg aaccaccagc cagctgcatt      360

tgttgtcctg gaagtcattg ccaactctgc cagtcacact ggggtcccca gagaagtcaa      420

gatctgccgg aggcgctggg caatgacccc gggactccag gccagagggg tctgaagctg      480

tttgggaaag cagcgggact ccttgggaag atggccatgg ccccaagccc ttccctggtg      540

caggtgtaca ccagccccgc ggctgtggcc gtgtgggaat ggcaggacgg gctgggcacc      600

tggcacccct acagtgccac cgtctgcagc ttcatcgagc agcagtttgt ccagcagaag      660

ggccaacgtt ttgggcttgg gagcctggcc cacagcatcc ccttgggcca ggcagacccc      720

tcgctggccc cttacattat tgacctcccc agctggaccc agttccgcca ggacaccggc      780

accatgcggg ctgtgcggag acacctgttc ccccagcact cagcccctgg ccgaggtgtc      840

gtctgggagt ggctgagcga cgatggctcc tggactgcct atgaagccag cgtctgtgac      900

tatctggagc agcaggtggc caggggcaac cagctcgtgg acttggcccc cctggggtac      960

aactacactg tcaactacac cacccacacg cagaccaaca agacttccag cttctgccgc     1020

agcgtgcggc gccaagcagg gccgccttac ccggtgacca ccatcatcgc tccgccgggc     1080

cacacaggcg tcgcctgctc ttgccaccag tgcctcagtg gcagcagaac tggccccgtg     1140

tcaggccgct accgccactc catgaccaac ctccctgcat accccgtccc ccagcacccc     1200

ccacacagga ccgcttctgt gtttgggacc caccaggcct ttgcaccgta caacaaaccc     1260

tcactctccg gggcccggtc tgcgcccagg ctgaacacca ccaacgcctg gggcgcagct     1320

cctccttccc tggggagcca gcccctctac cgctccagcc tctcccacct gggaccgcag     1380

cacctgcccc caggatcctc cacctccggt gcagtcagtg cctccctccc cagcggtccc     1440

tcaagcagcc cagggagcgt ccctgccact gtgcccatgc agatgccaaa gcccagcaga     1500

gtccagcagg cgctcgcagg catgacgagt gttctgatgt cagccattgg actccctgtg     1560

tgtcttagcc gcgcacccca gcccaccagc cctcccgcct cccgtctggc ttccaaaagt     1620

cacggctcag ttaagagatt gaggaaaatg tccgtgaaag gagcgacccc gaagccagag     1680

ccagagccag agcaggtcat aaaaaactac acggaagagc tgaaagtgcc cccagatgag     1740

gactgcatca tctgcatgga gaagctgtcc acagcgtctg gatacagcga tgtgactgac     1800

agcaaggcaa tcgggtccct agctgtgggc cacctcacca agtgcagcca tgccttccac     1860

ctgctgtgcc tcctggccat gtactgcaac ggcaataagg atggaagtct gcagtgtccc     1920

tcctgcaaaa ccatctatgg agagaagacg gggacccagc cccagggaaa gatggaggta     1980

ttacggttcc agatgtcgct ccccggccac gaggactgcg ggaccatcct catagtttac     2040

agcattcccc atggtatcca gggccctgag caccccaatc ccggaaagcc gttcactgcc     2100

agagggtttc cccgccagtg ctaccttcca gacaacgccc agggccgcaa ggtcctagag     2160

ctcctgaagg tggcctggaa gaggcggctc atcttcacag tgggcacgtc cagcaccacg     2220

ggtgagacgg acaccgtggt atggaacgag atccaccaca agacagagat ggaccgcaac     2280

attacgggcc acggctatcc cgaccccaac tacctgcaga acgtgctggc tgagctggct     2340

gcccaggggg tgaccgagga ctgcctggag cagcagcacg cccgcctctg gtggccaccc     2400

cgctgcccca tggctggctg ggtggccagg caggaagtgc ccagcccgag aggctgggag     2460

gtttgttga                                                             2469


<210> 4360
<211> 3253
<212> DNA
<213> Homo sapiens

<400> 4360
aaggaatgcc agcagctacc agaaaccgga agggcaagga atgcattctc cccagagcct       60

tcagaggaag catgactctg ctaacaccat gattcacaat tctggcctcc aagaacagag      120

agaataagcc tctattgttt aaaccacctg gtttgtccta attcgttatt gcagccacag      180

gaaactaata cagaaggcta aaatgaaaac gatgaagagg tgcagtatat tcaggctgag      240

aaaaacaaca agggcccaat ggaggctgcc acactttttc tcaagttcct gttggagctc      300

caggaggaag gctggttccg tggctttttg gatgccctag accatgcaga gctatggtgt      360

tttctatcaa cagaagaatc atgaagttca taaatttgga aaggagagct ttatttttca      420

taaagggttg cagtctgcat ggtggccatt ttgacaggct gggaagtgta gcctcgggcc      480

agaagcagga aacaggcact tggagggtgg ggagagtaaa acagagattt atgctgaata      540

gggtgaccaa atattcagta agctacagga ggagtcatga aagtagaagc atgcacctgg      600

gcaggttatt ctggacttta tgaagccatt gaaagttggg atttcaaaaa aattgaaaag      660

ttggaggagt atagattact tttaaaacgt ttacaaccag aatttaaaac cagaattatc      720

ccaaccgata tcatttctga tctgtctgaa tgtttaatta atcaggaatg tgaagaaatt      780

ctacagattt gctctactaa ggggatgatg gcaggtgcag agaaattggt ggaatgcctt      840

ctcagatcag acaaggaaaa ctggcccaaa actttgaaac ttgctttgga gaaagaaagg      900

aacaagttca gtgaactgtg gattgtagag aaaggtataa aagatgttga aacagaagat      960

cttgaggata agatggaaac ttctgacata cagattttct accaagaaga tccagaatgc     1020

cagaatctta gtgagaattc atgtccacct tcagaagtgt ctgatacaaa cttgtacagc     1080

ccatttaaac caagaaatta ccaattagag cttgctttgc ctgctatgaa aggaaaaaac     1140

acaataatat gtgctcctac aggttgtgga aaaacctttg tttcactgct tatatgtgaa     1200

catcatctta aaaaattccc acaaggacaa aaggggaaag ttgtcttttt tgcgaatcag     1260

atcccagtgt atgaacagca gaaatctgta ttctcaaaat actttgaaag acatgggtat     1320

agagttacag gcatttctgg agcaacagct gagaatgtcc cagtggaaca gattgttgag     1380

aacaatgaca tcatcatttt aactccacag attcttgtga acaaccttaa aaagggaacg     1440

attccatcac tatccatctt tactttgatg atatttgatg aatgccacaa cactagtaaa     1500

caacacccgt acaatatgat catgtttaat tatctagatc agaaacttgg aggatcttca     1560

ggcccactgc cccaggtcat tgggctgact gcctcggttg gtgttgggga tgccaaaaac     1620

acagatgaag ccttggatta tatctgcaag ctgtgtgctt ctcttgatgc gtcagtgata     1680

gcaacagtca aacacaatct ggaggaactg gagcaagttg tttataagcc ccagaagttt     1740

ttcaggaaag tggaatcacg gattagcgac aaatttaaat acatcatagc tcagctgatg     1800

agggacacag agagtctggc aaagagaatc tgcaaagacc tcgaaaactt atctcaaatt     1860

caaaataggg aatttggaac acagaaatat gaacaatgga ttgttacagt tcagaaagca     1920

tgcatggtgt tccagatgcc agacaaagat gaagagagca ggatttgtaa agccctgttt     1980

ttatacactt cacatttgcg gaaatataat gatgccctca ttatcagtga gcatgcacga     2040

atgaaagatg ctctggatta cttgaaagac ttcttcagca atgtccgagc agcaggattc     2100

gatgagattg agcaagatct tactcagaga tttgaagaaa agctgcagga actagaaagt     2160

gtttccaggg atcccagcaa tgagaatcct aaacttgaag acctctgctt catcttacaa     2220

gaagagtacc acttaaaccc agagacaata acaattctct ttgtgaaaac cagagcactt     2280

gtggacgctt taaaaaattg gattgaagga aatcctaaac tcagttttct aaaacctggc     2340

atattgactg gacgtggcaa aacaaatcag aacacaggaa tgaccctccc ggcacagaag     2400

tgtatattgg atgcattcaa agccagtgga gatcacaata ttctgattgc cacctcagtt     2460

gctgatgaag gcattgacat tgcacagtgc aatcttgtca tcctttatga gtatgtgggc     2520

aatgtcatca aaatgatcca aaccagaggc agaggaagag caagaggtag caagtgcttc     2580

cttctgacta gtaatgctgg tgtaattgaa aaagaacaaa taaacatgta caaagaaaaa     2640

atgatgaatg actctatttt acgccttcag acatgggacg aagcagtatt tagggaaaag     2700

attctgcata tacagactca tgaaaaattc atcagagata gtcaagaaaa accaaaacct     2760

gtacctgata aggaaaataa aaaactgctc tgcagaaagt gcaaagcctt ggcatgttac     2820

acagctgacg taagagtgat agaggaatgc cattacactg tgcttggaga tgcttttaag     2880

gaatgctttg tgagtagacc acatcccaag ccaaagcagt tttcaagttt tgaaaaaaga     2940

gcaaagatat tctgtgcccg acagaactgc agccatgact ggggaatcca tgtgaagtac     3000

aagacatttg agattccagt tataaaaatt gaaagttttg tggtggagga tattgcaact     3060

ggagttcaga cactgtactc gaagtggaag gactttcatt ttgagaagat accatttgat     3120

ccagcagaaa tgtccaaatg atatcaggtc ctcaatcttc agctacaggg aatgagtaac     3180

tttgagtgga gaagaaacaa acatagtggg tataatcatg gatcgcttgt acccctgtga     3240

aaatatattt ttt                                                        3253


<210> 4361
<211> 1470
<212> DNA
<213> Homo sapiens

<400> 4361
gctcgcgcgt gcgcaccaga agccagcagt ggggttgcac acgcgcctct tcacgaggtg       60

gaaacaagat ggaggattcg gcctcggcct cgctgtcttc tgcagccgct actggaacct      120

ccacctcgac tccagcggcc ccgacagcac ggaagcagct ggataaagaa caggaccttg      180

cctcatagta ttcgatcaga ttcagaagat atctgtttat ttacgaagga tgaacccaat      240

tcaactcctg aaaagacaga acagttttat agaaagcttt taaacaagca tggaattaaa      300

accgtttctc agattatctc cctccaaact ctaaagaagg aatataaatc ctatgaagcc      360

aagctccgcc ttctgagcag ttttgatttc ttccttactg atgccagaat taggcggctc      420

ttaccctcac tcattgggag acatttctat caaagaaaga aagttccagt atctgtaaac      480

cttctgtcca agaatttatc aagagagatc aatgactgta taggtggaac agtcttaaac      540

atttctaaaa gtggttcttg cagtgctata cgtattggtc acgttggaat gcaaattgag      600

cacatcattg aaaacattgt tgctgtcacc aaaggacttt cagaaaaatt gccagagaag      660

tgggagagcg tgaaactcct gtttgtgaaa actgagaaat cggctgcact tcccatcttt      720

tcctcgtttg tcagcaattg ggatgaagcc accaaaagat ctttgcttaa taagaagaaa      780

aaagaggcaa ggagaaaacg aagagaaaga aattttgaaa aacaaaagga gaggaagaag      840

aagaggcagc aggctaggaa gactgcatca gttcttagta aagatgatgt ggcacctgaa      900

agtggtgata ctacagtgaa gaaacctgaa tcaaagaagg aacagacccc agagcatggg      960

aagaaaaaac gtggcagagg aaaagcccaa gttaaagcaa caaatgaatc cgaagacgaa     1020

atcccacagc tggtaccaat aggaaagaag actccagcta atgaaaaagt agagattcaa     1080

aaacatgcca caggaaagaa gtctccagca aagagtccta atcccagcac acctcgtggg     1140

aagaaaagaa aggctttgcc agcatctgag accccaaaag ctgcagagtc tgagacccca     1200

gggaaaagcc cagagaagaa gccaaaaatc aaagaagagg cagtgaagga aaaaagtcct     1260

tcgctgggga aaaaagatgc gagacagact ccaaaaaagc cagaggccaa gtttttcacc     1320

actcctagta aatctgtgag aaaagcttcc cacaccccca aaaaatggcc caaaaaaccc     1380

aaagtacccc agtcgaccta aagtcagtga ttcaactgga aggaaacctc aatgctgcct     1440

ccagagcttt ttggaaatac tcagatcctg                                      1470


<210> 4362
<211> 1371
<212> DNA
<213> Homo sapiens

<400> 4362
aaaaacagtc cgcgacagct aggcgcgtga gaccggccgc ccgcagggct gctctggccg       60

ggacccgctg gccgggagac gcgaacctgc cggaccaccg cgcggggacg acggcggcca      120

tgagctcgcg gaagctgagc gggccgaaag gcaggaggct cagcatacac gtcgtgactt      180

ggaacgtggc ttcggcagcg ccccctctag atctcagtga cctgcttcag ctgaacaacc      240

ggaacctcaa tcttgacata tatgttattg gtttgcagga attgaactct gggatcataa      300

gcctcctttc cgatgctgcc tttaatgact cgtggagcag tttcctcatg gatgtgcttt      360

cccctctgag cttcatcaag gtctcccatg tccgtatgca ggggatcctc ttactggtct      420

ttgccaagta tcagcatttg ccctatatcc agattctgtc tactaaatcc acccccactg      480

gcctgtttgg gtactggctc agcattgcca agaaacatga cccgctgctc cgggagttcc      540

aggagggccg cctactcttc ccgcccacct acaagtttga taggaactcc aacgactatg      600

acaccagtga gaaaaaacgc aagcctgcat ggaccgatcg catcctgtgg aggctgaagc      660

ggcagccctg tgctggcccc gacactccca taccgccggc gtcacacttc tccttgtctc      720

tgaggggcta cagcagccac atgacgtacg gcatcagcga ccacaagcct gtctccggca      780

cgttcgactt ggagctgaag ccattggtgt ctgctccgct gatcgtcctg atgcccgagg      840

acctgtggac cgtggaaaat gacatgatgg tcagctactc ttcaacctcg gacttcccca      900

gcagcccgtg ggactggatt ggactgtaca aggtggggct gcgggacgtt aatgactacg      960

tgtcctatgc ctgggtcggg gacagcaagg tctcctgcag cgacaacctg aaccaggttt     1020

acatcgacat cagcaatatc cctaccactg aagatgagtt tctcctctgt tactacagca     1080

acagtctgcg ttctgtggtg gggataagca gacccttcca gatcccgcct ggctccttga     1140

gggaggaccc actgggtgaa gcacagccac agatctgagc caggatggga gtgaatccca     1200

ggcggaggcc agagctggca gccagctctg cctttccact gccgggagtg ctgggggccc     1260

agcctggccc cctgaagaga cagccaagtg tcgtccacat actcctccca gagtgagctc     1320

taaccaggct catttgctct ctccactact catctctgga attagccgct t              1371


<210> 4363
<211> 375
<212> DNA
<213> Homo sapiens

<400> 4363
atgaccggct cctgctgcgg ctccaccttc tcctccctga gctacggggg aggctgctgc       60

cagccctgct gctgccgcga cccctgctgc tgccgccccg tgacctgcca gaccaccgtg      120

tgccgccccg tgacctgcgt gccccgctgc acgcgcccca tctgcgagcc ctgccgccgc      180

ccggtgtgct gcgacccctg ctccctgcag gaaggctgct gccgccccat cacctgctgc      240

ccctcgtcgt gcacggctgt ggtgtgcagg ccctgctgct gggccaccac ctgctgccag      300

cctcctgtgt ctgtgcagtc cccctgcggc cagccgaccc cttgcagcac cacctgcagg      360

acctcctcct gctga                                                       375


<210> 4364
<211> 2037
<212> DNA
<213> Homo sapiens

<400> 4364
atcagtgtgt gcggaacgca agcagccgag agcggagagg cgccgctgta gttaactcct       60

ccctgcccgc cgcgccgacc ctccccagga acccccaggg agccagcatg aagcgagctc      120

accccgagta cagctcctcg gacagcgagc tggacgagac catcgaggtg gagaaggaga      180

gtgcggacga gaatggaaac ttgagttcgg ctctaggttc catgtcccca actacatctt      240

cccagatttt ggccagaaaa agacggagag gaataattga gaagcgccga cgagaccgga      300

tcaataacag tttgtctgag ctgagaaggc tggtacccag tgcttttgag aagcaggtaa      360

tggagcaagg atctgctaag ctagaaaaag ccgagatcct gcagatgacc gtggatcacc      420

tgaaaatgct gcatacggca ggagggaaag gttactttga cgcgcacgcc cttgctatgg      480

actatcggag tttgggattt cgggaatgcc tggcagaagt tgcgcgttat ctgagcatca      540

ttgaaggact agatgcctct gacccgcttc gagttcgact ggtttcgcat ctcaacaact      600

acgcttccca gcgggaagcc gcgagcggcg cccacgcggg cctcggacac attccctggg      660

ggaccgtctt cggacatcac ccgcacatcg cgcacccgct gttgctgccc cagaacggcc      720

acgggaacgc gggcaccacg gcctcaccca cggaaccgca ccaccagggc aggctgggct      780

cggcacatcc ggaggcgcct gctttgcgag cgccccctag cggcagcctc ggaccggtgc      840

tccctgtggt cacctccgcc tccaaactgt cgccgcctct gctctcctca gtggcctccc      900

tgtcggcctt ccccttctct ttcggctcct tccacttact gtctcccaat gcactgagcc      960

cttcagcacc cacgcaggct gcaaaccttg gcaagcccta tagaccttgg gggacggaga     1020

tcggagcttt ttaaagaact gatgtagaat gagggagggg aaagtttaaa atcccagctg     1080

ggctggactg ttgccaacat caccttaaag tcgtcagtaa aagtaaaaag gaaaaaggta     1140

cactttcaga taattttttt tttaaagact aaaggtttgt tggtttactt ttatcttttt     1200

taatgttttt ttcatcatgt catgtattag cagtttttaa aaactagttg ttaaattttg     1260

ttcaagacat taaattgaaa tagtgagtat aagccaacac tttgtgatag gtttgtactg     1320

tgcctaattt actttgtaaa ccagaatgat tccgtttttg cctcaaaatt tggggaatct     1380

taacatttag tatttttggt ctgtttttct ccttgtatag ttatggtctg tttttagaat     1440

taattttcca aaccactatg cttaatgtta acatgattct gtttgttaat attttgacag     1500

attaaggtgt tgtataaata atattctttt ggggggaggg gaactatatt gaattttata     1560

tttctgagca aagcgttgac aaatcagatg atcagcttta tccaagaaag aagactagta     1620

aattgtctgc ctcctatagc agaaaggtga atgtacacaa agaattttta atcacacgga     1680

tctcaaattc acaaatgtta acatggataa gtgatcatgg tgtgcgagtg gtcaattgag     1740

tagtacagtg gaaactgtta aatgcataac ctaattttcc tgggactgcc atattttctt     1800

ttaactggaa atttttatgt gagttttcct tttggtgcat ggaactgtgg ttgccaaggt     1860

atttaaaagg gctttcctgc ctccttctct ttgatttatt taatttgatt tgggctataa     1920

aatatcattt ttcaggttta ttcttttagc aggtgtagtt aaacgacctc cactgaactg     1980

ggtttgacct ctgttgtact gatgtgttgt gactaaataa aaaagaaaga acaaagt        2037


<210> 4365
<211> 5261
<212> DNA
<213> Homo sapiens

<400> 4365
cgagggccag cttggtggag cttagcacag cttgctcggc gctgcgagcg ggcgggggtg       60

gacactgggc ttctgtgtgc cagtcgcagc cgttggctgg cgggcaccca atcccagggc      120

atgccgccgg agcctggcca ggacgcacgg tgaaagacga gtttggtggc aggcttgacc      180

ccccggctgc cagcagaagc cggcgtcggg agcccaggcg ggcaggccgc tggggtcggg      240

gctgcacgta cgagagccgg gacgcccggg ttcagagcga aggaggaggc atggcttcgg      300

tgttcatgtg tggcgtggag gacctgctgt tcagcggcag ccgcttcgta tggaacttga      360

ccgtgtccac gctgcggaga tggtacacgg agaggctgcg ggcttgccac caggtgctgc      420

ggacgtggtg cgggctgcag gacgtgtacc agatgacaga aggcaggcac tgccaggtgc      480

acctcctgga tgataggaga ctggagctgc tggttcagcc caaacttcta gcaagagagt      540

tgctggacct agtggcttca catttcaacc tgaaagaaaa ggagtatttt ggaataacat      600

tcatagatga cacaggtcag cagaactggc tgcagttaga tcaccgagtt cttgaccacg      660

atttgcccaa gaaaccaggc ccaaccattt tgcactttgc tgtgaggttt tacattgaga      720

gcatatcgtt tttaaaggat aaaaccaccg tggagctgtt tttcctgaat gcaaaggcct      780

gtgtgcacaa ggggcaaatc gaagtagaga gcgaaaccat cttcaagtta gcagcgttta      840

ttttacagtc tcccaaagtc tcgcttaccc atgatgaaaa tgccaggaaa gatttaaaga      900

cattaccagc ctttccaacc aaaactcttc aggagcatcc atcccttgcc tactgtgagg      960

acagggtaat tgagcattat ttgaaaatca aaggtctcac tcgaggtcaa gctgtggttc     1020

agtatatgaa aatagtagaa gctctaccga cttacggtgt ccattattat gcagtaaagg     1080

ataagcaagg acttccttgg tggcttggaa taagctataa gggaattggc caatatgata     1140

tacaagacaa ggtgaagcct cggaagttat tccaatggaa acagctggag aacttatatt     1200

tccgtgagaa aaaatttgct gttgaagttc atgatccacg aaggatttca gtttcaagaa     1260

gaacctttgg gcaaagtggc ttgtttgtgc aaacatggta tgctaactct tctctcatca     1320

agtccatttg ggtaatggca attagtcagc atcagtttta cttggaccgg aagcaaagca     1380

aagcaaaaat tccttcagcc aggagtttag atgagattgc aatggatttg acagagacag     1440

gaacacaaag ggcctccaag ctggtgacac tggagacgaa aagtcagttc atcatggcaa     1500

gtaatggcag tttaatctcc tcaggttctc aagactcaga agttagtgaa gagcaaaaga     1560

gagaaaaaat ccttgaacta aagaagaagg agaaactatt acaagaaaaa cttctgaaaa     1620

aagttgagga gcttaagaag atctgtctgc gggaggctga gctcacaggc aaaatgccaa     1680

aggagtatcc cctgaacata ggcgagaagc ctcctcaggt cagaagacgt gtgggtactg     1740

cgttcaaatt agatgacaac ttgctgccga gtgaagaaga tcctgctttg caagaactgg     1800

agagtaattt tctaatacaa caaaagctgg tggaagctgc aaagaaactt gccaatgagc     1860

cagacctttg taaaactgtg aagaaaaagc gaaagcaaga ttacacagat gcgatgaaaa     1920

agcttcagga gattgaaaat gcaataaacg aataccgaat taggtgtgga aagaaaccca     1980

gccagaaagc aacagtgtta ccagaagaca taatcccctc agagagtagc tctttgtctg     2040

acaccaccac ctatgatgat cccagtgatg ccttcacttt tcctgggcag cgatcaagtt     2100

cagtacctca ttctccaaga attcttcccc ccaagtctct tggtattgag cgaatccatt     2160

tcagaaagtc gtccatcaat gaacagtttg tggataccag gcagtccaga gaaatgctgt     2220

ccacacacag cagcccttac aaaactctgg agaggcggcc ccagggagga cgaagcatgc     2280

ccaccacgcc agttcttacc cgaaacgcct acagcagcag ccacttggaa cccgaatctt     2340

catctcagca ctgccgccag cggagtggaa gcctggagtc ccagtcccac ctgctctccg     2400

agatggacag cgataagcca tttttctccc tctccaaatc ccaaagaagc agcagcacag     2460

aaatcctcga tgacgggtct tcttatacaa gccaatcaag cacagagtat tactgtgtga     2520

caccagttac cggcccctat tacaccaccc agaccctgga cactcgcacc aggggtcgga     2580

ggaggtcaaa gaaacagaat gtttctactt caaattcagg aagcatgccc aacctagcac     2640

aaaaggatag tttgaggaat ggtgtttact caaagagtca ggagccaccg tcttccagtt     2700

actacattgc cgggtacaca ccctatgcag agtgtgactt ttattacagt ggtggttatg     2760

tctatgagaa tgacaccgag ggacagtata gtgtcaaccc ttcctaccgg tcctcagccc     2820

actatggata tgagcgccag agggactaca gcagatcctt tcacgaagat gaggtcgacc     2880

gggtacccca taacccatat gcaactctcc ggctgccaag gaaggctgct gcaaaatcgg     2940

agcacatcac caaaaacatc cacaaggcct tagttgccga gcacttgcgt ggctggtacc     3000

agcgggcctc tgggcagaag gatcagggac acagcccgca gaccagcttt gactcagaca     3060

ggggatcaca gagatgcctg gggtttgcgg ggctgcaagt accttgttct ccaagcagtc     3120

gtgcatcctc gtactcttca gtgtcttcta caaatgcttc tgggaactgg aggacccagt     3180

taaccatagg gctgtcggat tacgagactc cagcacattc ttcttacacc agctgctatg     3240

gcaatgtcta taatccttta ccctctccaa gcagacaata cacagaaatc agtcaactgg     3300

atggtacaga tggaaaccag ctggaagaca acctggagag tagtgagcag agactctttt     3360

ggcatgaaga ttcaaagcct ggaacattag tctgaactgc agttggacct cctgaccaag     3420

cactgcgttc tcacactagt gtgccttgca aattgtattt gtcttccgag aggatgttcg     3480

ttttagaaac ctaaagacat caaaggttga agagaagact tagttgccct ggaagtgaat     3540

cagtgaatca cacaccaagc cccacaaagc ccctaaagga ggatttggcc tttcaaactc     3600

taggcactaa cgtaactgta gggtctgccc acatgttgaa gtattgccaa gagaggactc     3660

agtgtgaagc cttcatcaat agcaagcact ttttaaggga gtaaaagttg ttaaaggcaa     3720

acctcaaaaa catgaaaggg cattcaggat gtcccatggc aataagaaca ggggaaatct     3780

cagagcacaa ttcagcagga tgagagaagg ggaaccagaa gctccggagt cattgctcac     3840

ttcagagttt gaattcgtga gctgacaaag agtaacatgc tctttctaca cagacatgga     3900

caatttagac agtattggaa aattacttga agctggattt tcatgaagtt ctgaatgagt     3960

gtaaatgttt tttaggatac tataaagagt gatgtttttc ataagcacca taaaatgggt     4020

tctggaaaaa ctgattacct tagcatcctg taatataact tatggtagca gattggggaa     4080

aatgaagcag cccactgaat aattgacaaa gtctgcttgg agaacattct aaggtacaat     4140

atcatggagc tcctttttcc tttctccact aattgcgtga tgagctattg ttctggctgt     4200

taattctcca actcggctgt catttgaagt ggcagactta atatggaaag tttttataat     4260

tatgagtttg aaaaagcatt ttaagatgat acagaaagta tccaaaacaa cagaaaaaaa     4320

aagccacgtc attttagatg aattgcgtgc cttaaaatgg tgaacgttag aaaattaaac     4380

aagtctggat tccacaagta gttccaagtc accaagtgac aaaaacaagg ttaacattaa     4440

aaaagaaaaa caacaacaac gacaaaaagc tccaagctgc agtggattta attatgaggc     4500

taaaactacc tcatactttc cttggaagaa ctaattagct atggtttatt gtagggtttt     4560

gtttgtttgt tttttaaagc aaatgatttc catattccag attgatcttt tttgtcatct     4620

ttgcttcaaa attacataaa aggtgctcct ttcccccttc ttttatacaa gtttcttgtt     4680

catattgtga atagaaaagt ttctgaacaa cttttttgga acattttcta tctatattcc     4740

aaagcatgta atatatacat aaaaacgatt tgttaaactg gtccttagtc atttgtataa     4800

ttagaaatga agtttgggaa aaaattttgg aaaaaagaca agcaaaaaaa aataacttat     4860

tccttttttg catatttgta tagccttcta gaatcagaaa taaccttttt gcatattctt     4920

ttattgttct gacttttcaa gacctattat ttttttacat aggtcaataa acaaaaggtg     4980

tgctactgaa aatgtttacg ttttcttcca tttatgtcag gggttcatgt gaagcaggtc     5040

gcagtgctct acttcaagta atcatattgg gcaaggcttc ggatttttat ttatagtatt     5100

accgtatttt attaattccg ggatgtacat ttttaaatat ttacattaaa aacatggttc     5160

atctttttat tgatggcata ttctacttga attggcagtt ttttcttaat agtacattaa     5220

aaataatgct gtgtcttaca ataaagttgc cttagaattg a                         5261


<210> 4366
<211> 3868
<212> DNA
<213> Homo sapiens

<400> 4366
gcggcggcgg cggtgcctgg gcggcagcag cagcagtagc ggcagccctg aggacggtga       60

gacggccgcg gcggcggcga cagcgcggaa gtcgcgcggg acccagagct tcccccctgt      120

cgctagtgct gaggctttcg cctttcctac ccagcttctt gctcacggcc cgggctgggc      180

tgggcagggc aacgcgcccc cggggagggg cggagctgta gatatggtgt aagatacttc      240

ttcaagattg gacagctggg gaccttcttc tgattaacct taaaccaact tgtagccata      300

gagacacctc acaaggttcc catttttgtt gttgttgttg ttgattttct gctcacacct      360

ttcctgacct tgcaaccatg tatggaagtg cccgctctgt tgggaaggtg gagccgagca      420

gccagagccc tgggcgttca cccaggcttc cacgttcccc tcgcttgggt caccgtcgaa      480

ccaacagtac gggagggagt tcgggaagca gtgttggagg tggcagtggg aaaacccttt      540

caatggaaaa tatacaatct ttaaatgctg cctatgccac ctctggccct atgtatctaa      600

gtgaccatga aaatgtgggt tcagaaacac ctaaaagcac catgacactt ggccgttctg      660

ggggacgtct gccttacggt gttcggatga ctgctatggg tagtagcccc aatatagcta      720

gcagtggggt tgctagtgac accatagcat ttggagagca tcacctccct cctgtgagta      780

tggcatccac tgtacctcac tcccttcgtc aggcgagaga taacacaatc atggatctgc      840

agacacagct gaaggaagta ttaagagaaa atgatctctt gcggaaggat gtggaagtaa      900

aggagagcaa attgagttct tcaatgaata gcatcaagac cttctggagc ccagagctga      960

agaaggaacg agccctgaga aaagatgaag cttccaaaat caccatttgg aaggaacagt     1020

acagagttgt acaggaggaa aaccagcaca tgcagatgac aatccaggct ctccaggatg     1080

aattgcggat ccagagggac ctgaatcagc tgtttcagca ggatagtagc agcaggactg     1140

gcgaaccttg tgtagcagag ctgacagagg agaactttca gaggcttcat gctgagcatg     1200

agcggcaggc caaagagctg tttcttcttc gaaagacatt ggaggaaatg gagctgcgta     1260

ttgagactca aaagcagacc ctaaatgctc gggatgaatc cattaagaag cttctggaaa     1320

tgttgcagag caaaggactt tctgccaagg ctaccgagga agaccatgag agaacaagac     1380

gactggcaga ggcagagatg cacgttcatc acctagaaag ccttttggag cagaaggaaa     1440

aagagaacag tatgttgaga gaggagatgc atcgaaggtt tgagaatgct cctgattctg     1500

ccaaaacaaa agctctgcaa actgttattg agatgaagga ttcaaaaatt tcctctatgg     1560

agcgtgggct tcgagacctg gaagaggaaa ttcagatgct gaaatcgaat ggtgctttga     1620

gtactgagga aagggaagaa gaaatgaagc aaatggaagt gtatcggagc cattctaaat     1680

ttatgaaaaa taagattggc caggtgaaac aggagctgtc cagaaaggac acagaactac     1740

tcgccctgca gacaaagcta gaaacactca caaaccagtt ctcagatagt aaacagcaca     1800

ttgaagtgtt gaaggagtcc ttgactgcta aggagcagag ggctgccatc ctgcagactg     1860

aggtggatgc tctccgattg cgtttggaag agaaggaaac catgttgaat aaaaagacaa     1920

aacaaattca ggatatggct gaagagaagg ggacacaagc tggagagata catgacctca     1980

aggacatgtt ggatgtgaag gagcggaagg ttaatgttct tcagaagaag attgaaaatc     2040

ttcaagagca gcttagagac aaggaaaagc agatgagcag cttgaaagaa cgggtcaaat     2100

ccttgcaggc tgacaccacc aacactgaca ctgccttgac aactttggag gaggcccttg     2160

cagagaaaga gcggacaatt gaacgcttaa aggagcagag ggacagagat gagcgagaga     2220

agcaagagga aattgataac tacaaaaaag atcttaaaga cttgaaggaa aaagtcagcc     2280

tgttgcaagg cgacctttca gagaaagagg cttcactttt ggatctgaaa gagcatgctt     2340

cttctctggc atcctcagga ctgaaaaagg actcacggct taagacacta gagattgctt     2400

tggagcagaa gaaggaggag tgtctgaaaa tggaatcaca attgaaaaag gcacatgagg     2460

cagcattgga agccagagcc agtccagaga tgagtgaccg aatacagcac ttggagagag     2520

agatcaccag gtacaaagat gaatctagca aggcccaggc agaagttgat cgactcttag     2580

aaatcttgaa ggaggtggaa aatgagaaga atgacaaaga taagaagata gctgagttgg     2640

aaagtctcac ctcaaggcaa gtgaaagacc agaataagaa ggtagcaaat ctgaagcaca     2700

aggaacaggt ggaaaaaaag aagagtgcac aaatgttaga ggaggcgcga cgacgggagg     2760

acaatctcaa cgacagctct cagcagctac aggacagtct ccgtaagaag gatgacagga     2820

ttgaagagct ggaagaagca ctaagagaaa gtgtacagat aactgcagag cgggaaatgg     2880

tgctagcaca agaggaatca gccaggacca atgctgaaaa acaggtggag gagttactga     2940

tggccatgga gaaggtaaag caggaactag aatccatgaa agcaaagctg tcctccaccc     3000

agcagtctct ggcagaaaag gaaactcact tgactaatct tcgggcagag agaaggaaac     3060

acttagagga agttctggag atgaagcaag aagctcttct ggctgccatt agtgaaaaag     3120

acgccaatat agctctcttg gagctttcgt cctctaagaa gaagacccaa gaggaagtgg     3180

ctgccctgaa gcgggagaag gatcgtctgg tacagcagct taagcagcag acgcaaaatc     3240

gaatgaagct aatggccgac aactacgagg atgaccactt caaatcctcc cattccaatc     3300

aaacaaatca caagccctcc ccagaccagg atgaggagga gggtatatgg gcatagccaa     3360

tcagaggctt agttcagcca ttttgttcag aacgatcatc cagcccctct tagaacttga     3420

ccaaaataga agtaaattaa agttgtacat tggacacctg acaaccctct gccatgaccg     3480

agaccccctg atcctccgtg gactcactcc accagcttcc tataacttgg acgatgacca     3540

ggcggcttgg gagaatgagc tgcagaagat gacccggggg cagcttcagg atgagttaga     3600

gaaaggtgaa cgggacaatg cagaactgca ggagtttgcc aacgccattc ttcagcagat     3660

agcagaccat tgtcccgaca tcctagagca agtggtcaac gccctggaag agtcctcttg     3720

accctgcttt atggggaagc ctgaggtagt caacccagga gccaagaaaa gagaactacg     3780

aggaacaggt gcccggaacc ttcttggcac caaacactac aaacttcatc ccaacttgct     3840

cacttgaaga agtgtgattc cagcaccg                                        3868


<210> 4367
<211> 4384
<212> DNA
<213> Homo sapiens

<400> 4367
atgcttaccg tccaagtgaa gacttcctct gccatagaac ttccagattc cttggcattc       60

ctgtggatca tcccaatgtg gtactgtgaa ggcaaggagc ttgaaaattc cccagatatt      120

cacatcgtcc aggcaggaaa tctgcactca ctgaccattg cggaagcctt tgaagaggac      180

acaggacgct attcctgctt tgcttctaac atctatggga cagattcgac ttctgctgag      240

atttatatag aaggggtttc ttcttctgac tcagaaggcg accctaacaa ggaagagatg      300

aatcgaatcc agaagccaaa tgaggtgtca tctcctccca ctacctctgc agtcattcct      360

ccagcagtac cccaagccca gcatttggtg gcccaacctc gtgtggcaac catccagcag      420

tgtcagagcc ccaccaatta cttgcaggga ttggatggaa aacctatcat tgcagctcct      480

gtgtttacaa agatgctaca aaatttgtca gcttctgagg gtcagctggt tgtctttgaa      540

tgcagagtaa aaggagctcc atctcctaag gttgagtggt atagagaagg gactttaata      600

gaagattctc cagattttag gattttacag aaaaggcctg tctgcatgga gcatatagag      660

gagatttgca ccttggtcat tgctgaggtg tttgcagaag attctgggtg cttcacatgt      720

actgcaagca acaaatacgg cacagtgtca agcattgcac agctgcacgt gagaggaaat      780

gaggacctca gcaacaacgg gtctcttcac tcagccaact ctaccaccaa cctggcagct      840

attgagccac agccctcccc accccactca gagcctccat ctgtggaaca accccccaaa      900

cccaaactcg agggggttct ggtgaaccac aatgagcccc ggtccagctc caggattggg      960

cttcgtgtgc acttcaacct gcctgaagat gacaaaggaa gtgaagcatc ctccgaggct     1020

ggtgtggtga ccaccagaca gaccaggccc gattctttcc aggagaggtt caacggacag     1080

gcaacaaaaa ccccagagcc ttcttccccc gtgaaagagc cccctccagt tctggccaaa     1140

cccaaacttg attccactca gttacaacag cttcataacc aagtcttact ggaacaacac     1200

caattgcaaa acccacctcc ttcatctcct aaggagtttc ctttcagcat gactgttttg     1260

aactccaatg ctcccccagc ggtgacaaca tccagtaagc aggtgaaggc tccttcatca     1320

cagacgttca gcttggcccg gccgaagtat ttcttcccct ccacgaacac caccgcagca     1380

actgtggccc cttccagctc tccggtgttc actttgagca gcactcctca aactattcag     1440

aggacagtga gcaaagaaag cctcttagtg tctcacccct ctgtgcaaac caaatctcca     1500

ggagggcttt ccatccaaaa tgagccactc ccaccaggcc caacagaacc aacaccacca     1560

ccattcacat tttccatccc cagcggaaac cagtttcagc cccgctgtgt gtccccaatt     1620

cctgtctctc ctaccagccg gattcagaac ccagtggctt tcctcagctc tgttctgcct     1680

tctctccctg ccatcccacc cacaaatgcc atggggctgc ctagaagtgc accatccatg     1740

ccatcccagg gattagcgaa gaaaaataca aagtctcctc aaccagtgaa tgatgataac     1800

attcgtgaaa ctaagaacgc agtgattcga gacttgggga aaaaaataac tttcagtgat     1860

gtcagaccaa accagcagga gtacaaaatt tcaagctttg agcagaggct gatgaatgaa     1920

atagagtttc gcttggaacg tactcctgtt gatgaatcag atgatgaaat tcaacatgat     1980

gagatcccca cgggcaagtg tattgctccc atctttgaca agagactcaa gcacttccgg     2040

gtcacagaag gctctccagt tacattcacc tgcaaaattg ttgggatacc tgttccaaag     2100

gtttactggt tcaaagatgg gaagcagatt tctaagagaa atgagcactg caaaatgagg     2160

cgagaaggag atgggacatg ctctctgcac attgaatcca ctaccagtga tgacgatggc     2220

aactacacca tcatggcagc caacccccag gggagaatca gctgttctgg ccacttgatg     2280

gtacaaagtt tgcccattcg cagtcggcta acctctgctg gtcagtctca caggggaaga     2340

tcccgagtgc aagaaagaga caaagagccc ctacaggaac gctttttccg accacatttc     2400

ctgcaggctc ctggggatat ggtagctcat gaggggcgcc tctgtcggct ggactgtaag     2460

gtgagtggtt taccgccccc ggagctgaca tggctactca atggccaacc tgtgctacca     2520

gatgcctccc acaagatgct ggtcagggag accggagtcc actctctgct cattgaccca     2580

ctcactcagc gcgacgcagg gacctataag tgcatcgcta ccaacaaaac cgggcagaat     2640

tcttttagtc tggagctctc tgtagtagcc aaagaggtga agaaagcacc tgtgatcctg     2700

gagaaactac agaactgcgg tgttcccgaa ggccaccccg tgagactgga gtgccgcgtg     2760

ataggcatgc ccccacctgt gttctactgg aagaaagaca atgagaccat cccttgcacc     2820

agagagagga tcagtatgca ccaggacaca acagggtatg cctgccttct cattcagcca     2880

gccaagaaat cagacgctgg atggtacacg ttgtcagcca agaatgaagc cggcatcgtg     2940

tcgtgcactg ccaggctgga tatatacgct cagtggcacc atcagatccc accgcccatg     3000

tctgtccggc ccagtggcag tcgctacgga tctctcacca gtaaaggact tgacatattt     3060

tctgcctttt cctccatgga aagcacgatg gtgtattcat gctcttctcg gagtgtagtg     3120

gagagtgatg aactttaaga atgtctaggt acctgctgtg taagagagcg gactgtggag     3180

ggggaatgag aacaagccag acttggtggt ttccaagcaa ccgaagttga gtaagttccc     3240

acactgctgg acctgtggca aagagtgctt tgaataagtc agctagggat tcttgcagtc     3300

tcagctgagg gagaaaggta gggctgtgcc ttctaaagat tccaacagag atgtgagaag     3360

ataatacaga tgaaccaaag atgtcacaca gttgccatcc actgctttgg gaaaaaacta     3420

gcatgctccc ctgctccctg ttgtgttagg gatgtttagg tcatactagg agcaattagg     3480

agccatatgc ctgggctgag aagagctagg cagtagtgac cttaggatat gactaactca     3540

ccaaacaatg ccaaggagaa aggcggacag gtcaccatca cctttcatcg attacatgta     3600

tagcagtagt tttggtgaat tcaccaaatc agcttccact tagcattagg aggtcatgcc     3660

atacaactca cgtatgcggg caaacacttt tgatttgcat atcctgggtg tactgagcca     3720

cataataagg tgtcaaaatg tgcttgagat tccaaaaact tgctgaaaca cttgatattg     3780

cacagtgcac ttattttgtg gccaaagcat ggccttacca gcttgtctgc actattttct     3840

tttgggtggt gactgttttt ttctgacttt gcatatccct agacactaga actaaaggat     3900

tggtaataaa ccaatcagaa agaaatcctc tgtggggtca ctttaaaaac tactagcttc     3960

aactaccact tacaaaatgt gcaagagtca tcatttgccc ataaaataca cctcatgggc     4020

tcctacccct ttccccaaaa gtctgaaagt gtaggaggaa ggaagagata caaacaagga     4080

gaggaaatga tgggagagtg ttgtttttgt cacttgcccc agcagagcag gggttttgga     4140

aggagaggtc tttaatagct ttgaaatgct ttgagatcat tggtcaaatt gcattttcta     4200

tgtagagaat attctgctag gtggaaaagt tgggagaaag gggaatatgc atctttattc     4260

taatcaccaa ttcaaaccct gcctcttaag gaatttttag acttaagttc actgtgatat     4320

ccctagtacc tagaagagta cctagcacaa agtagacatt caataaatat ttgctggttg     4380

aatg                                                                  4384


<210> 4368
<211> 69
<212> DNA
<213> Homo sapiens

<400> 4368
gtgaggctgg cttggggctt cgtctcggct ctgggctcct tccacacggc tgaccctgaa       60

ggagcagcc                                                               69


<210> 4369
<211> 2273
<212> DNA
<213> Homo sapiens

<400> 4369
acacgccgcg ctgaggcccg cgggcccgtc atggaggcgc ccaccgtgga gacgcccccc       60

gacccctcgc ccccttcggc cccggcccct gccctggttc cgttgcgcgc cccggatgtg      120

gcgcggctgc gcgaggagca ggaaaaggtg gtcactaact gccaagagag aatccagcat      180

tggaagaagg tagataatga ctataatgcc cttcgagaaa gactcagcac cttgcctgat      240

aaattgtctt ataatataat ggtaccattt ggcccttttg ccttcatgcc aggaaaactt      300

gtccatacta atgaagtcac tgttttactg ggggacaact ggtttgcaaa gtgctcagca      360

aagcaggctg taggtttagt tgagcaccgg aaagaacatg taagaaaaac aatagatgac      420

ttaaaaaaag tgatgaaaaa ttttgaatcc agagttgaat tcacagaaga tttgcagaaa      480

atgagcgatg ctgcaggtga tattgttgac atacgagaag aaattaaatg tgacttcgaa      540

tttaaagcaa aacaccgaat tgctcataaa ccgcattcca aaccaaaaac ttcagatatt      600

tttgaagcag atattgcaaa tgatgtgaaa tccaaggatt tgctagctga taaagaactg      660

tgggctcgac ttgaagaact agagagacag gaagaattgc tgggtgaact tgatagtaag      720

cctgatactg tgattgcaaa tggagaagat acgacatctt ctgaagagga aaaggaagat      780

cgtaacacaa atgtgaatgc gatgcatcaa gtaacagact ctcatactcc ttgtcataag      840

gatgttgcaa gttcagaacc attcagtggt caagtgaata gtcagttgaa ctgttcagtg      900

aatggttcca gttcttacca cagtgatgat gatgatgatg atgatgatga cgacgacgac      960

gacaacattg acgacgatga tggtgataac gaccatgagg ctttaggggt tggagataat     1020

tctataccaa caatatattt ttcacatact gttgagccta agagggtccg aataaatact     1080

ggaaagaata ccactttaaa attcagtgaa aagaaagaag aagccaaacg taaacgaaag     1140

aacagcactg gcagtggcca ctctgcccag gagctgccga ccatcaggac gcctgcagac     1200

atttacagag cctttgttga tgttgtgaat ggagaatatg tccctcgcaa atccatcctg     1260

aagtctcgaa gtagagagaa tagtgtgtgt agcgacacta gtgaaagcag tgctgctgaa     1320

tttgatgata ggcggggagt tttgaggagt atcagctgcg aagaagccac ttgcagtgac     1380

accagtgaga gcattttgga agaggaacca caagaaaatc aaaagaaact tttgccctta     1440

tcagtaacac ctgaggcttt ttctggaact gttatagaaa aagaatttgt atcaccttcc     1500

ttaacaccac ccccagccat tgctcatccc gcactaccca ctattccaga acgaaaggaa     1560

gttctgttgg aagcatctga agaaactgga aagagggttt caaagtttaa agctgccaga     1620

ttgcaacaga aagactaggc cctgtctagg aaatgggaat ttacatccta aaacctagtt     1680

gttcatttgt ttagagtatc tatagcaaaa taggttacat gtagtttgaa ataaggtatc     1740

ctgagttact ttggcaacaa gttcttttac ccttacccgt ggtatttgaa aaaaatcaag     1800

gtaactgtct gaatacttta atatcagctt gttttgtgaa ttctctgaat actgtcaaca     1860

ctcttatcta agtttgcctt tatgatgcag tggcagcatt ttgaattact tttcaaagaa     1920

tactgttcat atgcattgtt tttgtgtttc aaactaaata caggcagttt tgtgccagct     1980

gtgatattgt gcataccata tggaccattt taaagaaaat tttaaaattt caaatagatt     2040

caacaattac attacttgct ttcacatttt aaaggcactt taaaaaaatc tacttctctt     2100

gtaggttttg cggctagttg gctattcaag aaacctcgcc cctctgaatg tcatactgta     2160

atctttaagg aagaaagcta catgaattaa ttgtactcta tgggaaaatt tctttggaaa     2220

gatattttgt aaaacttttt tttccaagta aaaactttat gaaacttggt ctc            2273


<210> 4370
<211> 1865
<212> DNA
<213> Homo sapiens

<400> 4370
aacaagttaa gctgaagacc gaagcaagag ctggttcaga gcctgccttc aacccccaaa       60

gcagcttgga tcagggagga gggccgctgc tccagcagtg acgatgacac cgacgtggac      120

atggagggtc tgcggagacg gcggggccgg gaggccggcc cacctcagcc catggtgccc      180

ctggctgtgg agaaccaggc tgggggtgag ggtgcaggcg gggagctggg catctccctc      240

aacatgtgcc tccttggggc cctggttctg cttggcctgg gggtcctcct cttctcaggt      300

ggcctctcag agtctgagac tgggcccatg gaggaagtgg agcggcaggt cctcccagac      360

cccgaggtgc tggaagctgt gggggacagg caggatgggc taagggaaca gctgcaggcc      420

ccagtgcctc ctgacagtgt ccccagcctg caaaacatgg gtcttctgct ggacaagctg      480

gccaaggaga accaggacat ccggctgctg caggcccagc tgcaggccca aaaggaagag      540

cttcagagcc tgatgcacca gcccaaaggg ctagaggagg agaatgccca gctccggggg      600

gctctgcagc agggcgaagc cttccagcgg gctctggagt cagagctgca gcagctgcgg      660

gcccggctcc aggggctgga ggccgactgt gtccggggcc cagatggggt gtgcctcagt      720

gggggtagag gcccacaggg tgacaaggcc atcagggagc aaggccccag ggagcaggag      780

ccagaactca gcttcctgaa gcagaaggaa cagctggagg ctgaggcaca ggcattaagg      840

caagagttag agaggcagcg acggctgctg gggtctgtac agcaggatct ggagaggagc      900

ttgcaggatg ccagccgcgg ggacccagct catgctggct tggctgagct gggccacaga      960

ttggcccaga aactgcaggg cctggagaac tggggccagg accctggggt ctctgccaat     1020

gcctcaaagg cctggcacca gaagtcccac ttccagaatt ctagggagtg gagtggaaag     1080

gaaaagtggt gggatgggca gagagaccgg aaggctgagc actggaaaca taagaaggaa     1140

gaatctggcc gggaaaggaa gaagaactgg ggaggtcagg aggacaggga gccagcagga     1200

aggtggaagg agggcaggcc aagggtggag gagtcgggga gcaagaagga gggcaagcga     1260

cagggcccga aggaaccccc aaggaaaagt ggtagcttcc actcctctgg agaaaagcag     1320

aagcaacctc ggtggaggga agggactaag gacagccatg accccctgcc atcctgggca     1380

gagctgttga ggcccaagta ccgggcaccc cagggctgct caggtgtgga cgagtgtgcc     1440

cggcaggagg gcctgacttt ctttggcaca gagctagccc cagtgcggca acaggagctg     1500

gcctctctgc taagaacata cttggcacgg ctgccctggg ctgggcagct gaccaaggag     1560

ctacccctct cacctgcttt ctttggtgag gatggcatct tccgtcatga ccgcctccgc     1620

ttccgggatt ttgtggatgc cctggaggac agcttggagg aggtggctgt gcaacagaca     1680

ggtgatgatg atgaagtaga tgactttgag gacttcatct tcagccactt ctttggagac     1740

aaagcactga agaagaggtc agggaagaag gacaagcact cacagagccc aagagctgcg     1800

gggcccaggg aggggcacag ccatagccac caccaccacc accggggctg acaccctgcc     1860

ccaca                                                                 1865


<210> 4371
<211> 2391
<212> DNA
<213> Homo sapiens

<400> 4371
ccgcagttct tgagttccac atgcagagca gatgcgacag ctagaagtga gtagggccca       60

gaccctggcc caggaagatc cactaaagga ggccatcctt ccgccttctt ctgcaggagt      120

caggatggaa aggcagatgt aaagtccctc atggcgaaat ataacacggg gggcaacccg      180

acagaggatg tctcagtcaa tagccgaccc ttcagagtca cagggccaaa ctcatcttca      240

ggaatacaag caagaaagaa cttattcaac aaccaaggaa atgccagccc tcctgcagga      300

cccagcaatg tacctaagtt tgggtcccca aagccacctg tggcagtcaa accttcttct      360

gaggaaaagc ctgacaagga acccaagccc ccgtttctaa agcccactgg agcaggccaa      420

agattcggaa caccagccag cttgaccacc agagaccccg aggcgaaagt gggatttctg      480

aaacctgtag gccccaagcc catcaacttg cccaaagaag attccaaacc tacatttccc      540

tggcctcctg gaaacaagcc atctcttcac agtgtaaacc aagaccatga cttaaagcca      600

ctaggcccga aatctgggcc tactcctcca acctcagaaa atgaacagaa gcaagcgttt      660

cccaaattga ctggggttaa agggaaattt atgtcagcat cacaagatct tgaacccaag      720

cccctcttcc ccaaacccgc ctttggccag aagccgcccc taagtaccga gaactcccat      780

gaagacgaaa gccccatgaa gaatgtgtct tcatcaaaag ggtccccagc tcccctggga      840

gtcaggtcca aaagcggccc tttaaaacca gcaagggaag actcagaaaa taaagaccat      900

gcaggggaga tttcaagttt gccctttcct ggagtggttt tgaaacctgc tgcgagcagg      960

ggaggcccag gtctctccaa aaatggtgaa gaaaaaaagg aagataggaa gatagatgct     1020

gctaagaaca ccttccagag caaaataaat caggaagagt tggcctcagg gactcctcct     1080

gccaggttcc ctaaggcccc ttctaagctg acagtggggg ggccatgggg ccaaagtcag     1140

gaaaaggaaa agggagacaa gaattcagcc accccgaaac agaagccatt gcctcccttg     1200

tttaccttgg gtccacctcc accaaaaccc aacagaccac caaatgttga cctgacgaaa     1260

ttccacaaaa cctcttctgg aaacagtact agcaaaggcc agacgtctta ctcaacaact     1320

tccctgccac cacctccacc atcccatccg gccagccaac caccattgcc agcatctcac     1380

ccatcacaac caccagtccc aagcctacct cccagaaaca ttaaacctcc gtttgaccta     1440

aaaagccctg tcaatgaaga caatcaagat ggtgtcacgc actctgatgt agttattcct     1500

ctggaccatg aacaagacag tgaaggagaa acatatgaag acatagaagc atccaaagaa     1560

agagagaaga aaagggaaaa ggaagaaaag aagaggttag agctggagaa aaaggaacag     1620

aaagagaaag aaaagaaaga acaagaaata aagaagaaat ttaaactaac aggccctatt     1680

caagtcatcc atcttgcaaa agcttgttgt gatgtcaaag gaggaaagaa tgaactgagc     1740

ttcaagcaag gagagcaaat tgaaatcatc cgcatcacag acaacccaga aggaaaatgg     1800

ttgggcagaa cagcaagggg ttcatatggc tatattaaaa caactgctgt agagattgac     1860

tatgattctt tgaaactgaa aaaagactct cttggtgccc cttcaagacc tattgaagat     1920

gaccaagaag tatatgatga tgttgcagag caggatgata ttagcagcca cagtcagagt     1980

ggaagtggag ggatattccc tccaccacca gatgatgaca tttatgatgg gattgaagag     2040

gaagatgctg atgatggctc cacactacag gttcaagaga agagtaatac gtggtcctgg     2100

gggattttga agatgttaaa gggaaaagat gacagaaaga aaagtatacg agagaaacct     2160

aaagtctctg actcagacaa taatgaaggt tcatctttcc ctgctcctcc taaacaattg     2220

gacatgggag atgaagttta cgatgatgtg gatacctctg atttccctgt ttcatcagca     2280

gagatgagtc aaggaactaa tgttggaaaa gctaagacag aagaaaagga ccttaagaag     2340

ctaaaaaagc aggaaaaaga agaaaaagac ttcaggaaaa aatttaaaaa a              2391


<210> 4372
<211> 2437
<212> DNA
<213> Homo sapiens

<400> 4372
atgacttctg ccttcaagct ggatttcctc ccggacatga tggtcgaggg ccgcctgctc       60

gttcctgaca gaattaacgg cacagccaac aagatgaacg gagctttgga tcactcagac      120

caaccagacc cagatgccat taagatgttt gtcggacaga tcccccggtc atggtcggaa      180

aaggagctga aagaactttt tgagccttac ggagccgtct accagatcaa cgtcctccgg      240

gaccggagtc agaaccctcc gcagagtaaa ggttgttgtt tcgtaacatt ttatacaaga      300

aaagctgcac ttgaggccca gaatgcactg cacaatatta aaactttacc tgggatgcat      360

catcccattc agatgaaacc tgcagatagt gaaaagtcca acgctgtgga agacagaaaa      420

ttgttcatag gaatggtatc gaagaaatgt aatgagaacg acatcagggt gatgttctct      480

ccatttggcc agatagaaga atgccggatc ctccggggac ctgatgggct gagtcgaggc      540

tgtgcgtttg tcacattttc tacaagggca atggcacaga atgcaatcaa agccatgcat      600

cagtctcaga ccatggaggg ctgctcttca cctatcgtgg tgaagtttgc tgacactcag      660

aaggacaaag agcaaaggcg cctccagcag cagctcgctc agcagatgca gcagctcaac      720

actgccacct gggggaacct gacagggctg ggcggactga ccccacagta tctggcgctc      780

ctgcagcagg ccacctcctc cagcaacctg ggtgcgttca gcggcattca acaaatggca      840

ggcatgaatg ctttacagtt gcagaacctg gcgacgctgg ctgctgctgc agctgcggcc      900

cagacctcag ccaccagcac caatgcaaac cctctctcta ccacgagcag cgccctggga      960

gccctcacga gtcccgtggc tgcttcaacc cccaactcca ctgctggtgc agccatgaac     1020

tccttgacct ctctcgggac tctgcaagga ctggctggag ccactgttgg actgaataat     1080

attaatgcac tagcagttgc tcaaatgctc tcaggtatgg cggctctgaa tggaggactt     1140

ggcgccacag gcttgacgaa tggcacggct ggcaccatgg acgccctcac ccaggcctac     1200

tcaggaattc aacagtacgc agccgccgcg ctgcccactc tgtacagcca gagcctgctg     1260

cagcagcaga gcgctgcagg cagccagaag gaaggtccag agggggcaaa cctctttatt     1320

taccaccttc cacaggaatt tggagaccag gacattctgc agatgttcat gccttttgga     1380

aatgttatct ctgctaaagt cttcattgac aaacagacca atctgagcaa gtgctttggt     1440

tttgttagct acgacaatcc agtctctgca caagctgcta tccaagctat gaatggcttt     1500

cagatcggca tgaaacgctt gaaggtgcag ctgaagcgtt ccaaaaacga cagcaaacct     1560

tactgatcct aaccccagag gctccctgct ctcattttag ctttcttagg acatcttcat     1620

gcccgttagt tcatcgtttg cctagcatgt ccctgtggcg tctcaaaaaa aagtttcatc     1680

gtcccgtcat tgtttctgat gtctttctga cctcacatca tatttggttc tcctactgac     1740

ctttgatcta gtttgacctt tgaaatttgc atgtgacctc atctagctat gaattctggg     1800

aagtcaatgt gaaaaacatt gctgcattca tgcaagactg aaatttatta ttagacaaat     1860

tcattataga aaaaacctgt ggcaaaaacg tttctttctt attttttttc ttttcctaaa     1920

acagacttga aagtattata cagggattgg cattcttccc ggtcactggt aacaatagca     1980

atatgtgtcc agggacacag aatgttggtt tctaacagac tacttccaaa aacagtttga     2040

gaaaaaaact gtctgatttt aagtctctag aggtctgtaa tagtttttac atttttcagg     2100

cagtgtaaag ttttttgata aggccatttt aggtggctca ctttctcatt aagatatata     2160

tatagaacca ctttttgtag attagtataa gaaaaatatt taccctgttt tggggcaaat     2220

gctacctatt tgtgtcacct tttgctgaac tcacagttag acaatccatg gtttaatgca     2280

catgaaatta cctatatttt atactgtttc aatgtacagg agaaaggtta ctgtaaactg     2340

tgttatgttg gtgcttctgt gaattaagtt gtggtttcat catgagtctt aatgttcttt     2400

gttgataaga caagtttaga attggtttac ttaatac                              2437


<210> 4373
<211> 1959
<212> DNA
<213> Homo sapiens

<400> 4373
cccctcagga gaagtcggga aggtggcggc ggcggcggcg gttgtcccgg ctgtgccggt       60

tggtgtggcc cgtcagcccg cgtaccacag cgcccgggcc gcgtcgagcc cagtacagcc      120

aagccgctgc ggccgggtcc ggcgcgggcg gcgcgaagcg gaagcaggag gagaagcacc      180

tgaagatgct gcgggacatg accggcctcc cgcacaaccg aaagtgcttc gactgcgacc      240

agcgcggccc cacctacgtt aacatgacgg tcggctcctt cgtgtgtacc tcctgctccg      300

gcagcctgcg aggattaaat ccaccacaca gggtgaaatc tatctccatg acaacattca      360

cacaacagga aattgaattc ttacaaaaac atggaaatga agtctgtaaa cagatttggc      420

taggattatt tgatgataga tcttcagcaa ttccagactt cagggatcca caaaaagtga      480

aagagtttct acaagaaaag tatgaaaaga aaagatggta tgtcccgcca gaacaagcca      540

aagtcgtggc atcagttcat gcatctattt cagggtcctc tgccagtagc acaagcagca      600

cacctgaggt caaaccactg aaatctcttt taggggattc tgcaccaaca ctgcacttaa      660

ataagggcac acctagtcag tccccagttg taggtcgttc tcaagggcag cagcaggaga      720

agaagcaatt tgacctttta agtgatctcg gctcagacat ctttgctgct ccagctcctc      780

agtcaacagc tacagccaat tttgctaact ttgcacattt caacagtcat gcagctcaga      840

attctgcaaa tgcagatttt gcaaactttg atgcatttgg acagtctagt ggttcgagta      900

attttggagg tttccccaca gcaagtcact ctccttttca gccccaaact acagcattta      960

gaatgctttc atctagctgc agttttggtg aatttacttc agcttttcct cttcaggcta     1020

cccacagtgg aagtgctgca tcagtaaatg ctaattttgc tcattttgat aacttcccca     1080

aatcctccag tgctgatttt ggaaccttca atacttccca gagtcatcaa acagcatcag     1140

ctgttagtaa agtttcaacg aacaaagctg gtttacagac tgcagacaaa tatgcagcac     1200

ttgctaattt agacaatatc ttcagtgccg ggcaaggtgg tgatcaggga agtggctttg     1260

ggaccacagg taaagctcct gttggttctg tggtttcagt tcccagtcag tcaagtgcat     1320

cttcagacaa gtatgcagct ctggcagaac tagacagcgt tttcagttct gcagccacct     1380

ccagtaatgc gtatacttcc acaagtaatg ctagcagcaa tgtttttgga acagtgccag     1440

tggttgcttc tgcacagaca cagcctgctt catcaagtgt gcctgctcca tttggagcta     1500

cgccttccac aaatccattt gttgctgctg ctggtccttc tgtggcatct tctacaaacc     1560

catttcagac caatgccaga ggagcaacag cggcaacctt tggcactgca tccatgagca     1620

tgcccacagg attcggcact cctgctccct acagtcttcc caccagcttt agtggcagct     1680

ttcagcagcc tgcctttcca gcccaagcag ctttccctca acagacagct ttttctcaac     1740

agcccaatgg ttttgcagca tttggacaaa caaagccagt agtaacccct tttggtcaag     1800

ttgcagctgc tggagtatct agtaatcctt ttatgactgg tgcaccaaca ggacaatttc     1860

caacaggaag ctcatcaacc aatcctttct tatagcctta tatagacaat ttactggaac     1920

gaacttttat gtggtcacat tacatctctc cacctcttg                            1959


<210> 4374
<211> 3403
<212> DNA
<213> Homo sapiens

<400> 4374
aggaatggtt ttagggaaga ctgttgccgg atgacaaggc tgtcactatt gttctgtact       60

acctgacatt atgggaccag gccagccagc ttcaacctgt gttcatctag cacctaggac      120

ccaacttgat gggaggagcg accccaaagt acttcagacc cagaaccagc tgcagtttaa      180

taggaatgtt cctacacatt caagcaactt ggcgatccga tattcttgcc cacatgccat      240

tagaattgaa aaactgaagc actcatacaa tgaatcatac cattgtaaag atgcagattg      300

tagagttggt cctgacctgg gcagttctgt ttcattttcc gtcatatccc aagagagact      360

tagctatgct gtccacctag ccagaagaga tgtgaaacga agacaatttg aaaaacatat      420

aaaagaacat catctcagaa gtcagcctca aagctctcag aagtgtggac atactaagta      480

taaaataccc gaccacaggg tggaaaggaa ggaatcaaag agtcaagcag cctgtcagtg      540

tagccaccag ccatccaaag tagaaatctc cagctctggt gccaaagtat acctttactc      600

atctcatcca ggccagtcag atcttactgt gccaaattcg ccacccaccc atgatccggg      660

acttcagcct catcccagga taggtgacca caaaaacata agtgaacaga aaagcctgct      720

agaagtccag cgactccaga aagaactgag cagttgtatc cacaaaattg aagaggtaac      780

taaaaaaggt aaaagaaatc caggaagaat tggataaatt gagtccacat aaaattaaac      840

acactaagaa gtcatgggca atgtctaagc tggcggctgc ccatcgagga gccattcggg      900

ccttacagat gtttgtcact cagtttactg accgagggga gcatccactt cctgctcggt      960

gtaaggaact gggcagcctt attcgccagc tttcactttg ttctgtcaag ctggatgcag     1020

acccttctgt tcctgatgtg gttatagata ttctgcaaca aattgaggct ttggaatctc     1080

tcctggaaaa gaaactgtca ccaaaaaagg tgaaaaaatg tttcagtgaa attcggagca     1140

gatttcctat cggtagccaa aaggccttgg agagatggcc aagtacatca ccaaagggtg     1200

agaggaggcc cctcacagca aaggacacat tcccacagga aacaagtcga ccttctgtag     1260

caaagcagct tcttgccgat aagtatcagc ccgatacgga gcttccggag acccagaggt     1320

tgcagagtga gcttgatgta ttagatgcgg atatagttct ggaagaagga ccatttattc     1380

tagaccaaag tgcaagcttc aaagacgagg tgttagccgt ggcaaaaaca aaagcaggga     1440

aaaagaagcc tgtgactgag aatgtgccgt ttaggaagaa agatactctg gcgccagcaa     1500

gacagcaagg actccgcaaa gctgaaagag gtagacaaag ccaacctcac agtaaaagca     1560

gagtgcagca gacaacagtt tcatccagat taaaaatgaa ccggcagcct gtgaaagacc     1620

gcaaggcacc atggataccc ccaaacccca catccccacc agcgtctcct aaatgtgctg     1680

catggctaaa ggtgaaaact agccccagag atgccacaaa agagcctctc cagcaagaag     1740

atcctcaaga ggaaagtcac ctgacaggtg ctgttgagca tgaagcagcc aggctcgctt     1800

ggcttgatgc tgaaacttcc aaaagattga aggaactaga agagttaaaa gccaaggaaa     1860

ttgacagcat gcaaaaacag aggcttgatt ggcttgatgc tgaaacttct agaagaacaa     1920

aggaactgaa tgagctcaaa gctgaagaaa tgtatagact ccaacaattg agtgtttctg     1980

ccacccactt agcagacaag gtagaggagg cagttctgga tcgtttgaag cctctcttgg     2040

tcaaggccca gagagtcaat tctactacag aagcaaatat tcatttgaaa gatggctcgt     2100

cagtaaacac agcgaaagcc cagcctgcac aggaggttgc agctgttgat tttgaatcca     2160

acaacattcg tcagcttgat gattttttgg aagattgtgc cagtgagctc tgggctgtga     2220

ctcatgctaa gatcttgggg tctgaaacct tagccaccgt tgaggacagc aaggatagcc     2280

cagatctgga gatcatgatg cgccgaatgg aagagatgga aaaataccag gagtctgttc     2340

gtcaaagata taataaaatc gcatatgctg atcctcgact ttggatgcag gaagaaaaca     2400

atgaccaaaa aatctcagca ataagtgaaa agcctctatc tcctcatcca atcagaatca     2460

cgaagacagt ggatcgcaag gatccagccg tgaacatcat gttagaaagg ccctgtaatg     2520

gcaattccct ggatgaaagt gtgggaacag aggaaggatc agagaaaaga gaggcccctc     2580

ttctctccct agccgaagat tctcaacaga aagaaggccg agctcccctc tttgtcccac     2640

cgggtatgca gcacagcatc ggtgactact gtagtcgttt tgagcagtac cttcggatca     2700

tatctcatga ggctgtaggc tccttcaacc cgtggctgat agctgaaagc ttttcagaag     2760

agctggtaga tgaagctctg ggtgctgtgg ctgctgaact tcaggatatg tgcgaagatt     2820

atgcagaagc tgtgttcacc tcagaattct tagaggctgc tacataaagg ctctctgagg     2880

cgaggccatt tgtgtcacac tggagaaggg atggcaccac cctttgtttt ggcccacagg     2940

aaattttcat cctcagctgt ccatccaggc ccagaaggtg ctgcccactg aaaggaaggc     3000

agtgccgggg aggtcatcct cactttgcat tttcttttgt catggcaatg gttctggaaa     3060

tgtatgatgc aatgtatcac acttatcagt gcccaggcaa cacaacttga ttatggcaat     3120

attttcagaa tgtgtacttt tcctattgaa ataccatgtt cattcctctg gctcagtttg     3180

gtgatgaaaa tgttttgaaa gataatcgat acgtatattt cacacaagga ttcaggttgc     3240

tgttgaaccc ttgctggcat tgataccaac acaagtgcgg ctactagctg gtcccatcac     3300

ggggcccctg ttttgcatct ttggcgattt cctgtcagga cctctggccc tactaggctg     3360

tagactcagg gagagcacag tctggctgtg ctgccaaacc tct                       3403


<210> 4375
<211> 3700
<212> DNA
<213> Homo sapiens

<400> 4375
cagccgcgtc ccccagcccc ggcctcccgc ggacccatgc ccgcccgtat cggctactac       60

gagatcgacc gcaccatcgg caagggcaac ttcgcggtgg tcaagcgggc cacgcacctc      120

gtcaccaagg ccaaggttgc tatcaagatc atagataaga cccagctgga tgaagaaaac      180

ttgaagaaga ttttccggga agttcaaatt atgaagatgc tttgccaccc ccatatcatc      240

aggctctacc aggttatgga gacagaacgg atgatttatc tggtgacaga atatgctagt      300

ggaggggaaa tatttgacca cctggtggcc catggtagaa tggcagaaaa ggaggcacgt      360

cggaagttca aacagatcgt cacagctgtc tatttttgtc actgtcggaa cattgttcat      420

cgtgatttaa aagctgaaaa tttacttctg gatgccaatc tgaatatcaa aatagcagat      480

tttggtttca gtaacctctt cactcctggg cagctgctga agacctggtg tggcagccct      540

ccctatgctg cacctgaact ctttgaagga aaagaatatg atgggcccaa agtggacatc      600

tggagccttg gagttgtcct ctacgtgctt gtgtgcggtg ccctgccatt tgatggaagc      660

acactgcaga atctgcgggc ccgcgtgctg agtggaaagt tccgcatccc attttttatg      720

tccacagaat gtgagcattt gatccgccat atgttggtgt tagatcccaa taagcgcctc      780

tccatggagc agatctgcaa gcacaagtgg atgaagctag gggacgccga tcccaacttt      840

gacaggttaa tagctgaatg ccaacaacta aaggaagaaa gacaggtgga ccccctgaat      900

gaggatgtcc tcttggccat ggaggacatg ggactggaca aagaacagac actgcaggcg      960

gagcaggcag gtactgctat gaacatcagc gttccccagg tgcagctgat caacccagag     1020

aaccaaattg tggagccgga tgggacactg aatttggaca gtgatgaggg tgaagagcct     1080

tcccctgaag cattggtgcg ctatttgtca atgaggaggc acacagtggg tgtggctgac     1140

ccacgcacgg aagttatgga agatctgcag aagctcctac ctggctttcc tggagtcaac     1200

ccccaggctc cattcctgca ggtggcccct aatgtgaact tcatgcacaa cctgttgcct     1260

atgcaaaact tgcaaccaac cgggcaactt gagtacaagg agcagtctct cctacagccg     1320

cccacgctac agctgttgaa tggaatgggc ccccttggcc ggagggcatc agatggagga     1380

gccaacatcc aactgcatgc ccagcagctg ctgaagcgcc cacggggacc ctctccgctt     1440

gtcaccatga caccagcagt gccagcagtt acccctgtgg acgaggagag ctcagacggg     1500

gagccagacc aggaagctgt gcagaggtac ttggcaaata ggtccaaaag acatacactg     1560

gccatgacca accctacagc tgagatccca ccggacctac aacggcagct aggacagcag     1620

cctttccgtt cccgggtctg gcctcctcac ctggtacctg atcagcatcg ctctacctac     1680

aaggactcca acactctgca cctccctacg gagcgtttct cccctgtgcg ccggttctca     1740

gatggggctg cgagcatcca ggccttcaaa gctcacctgg aaaaaatggg caacaacagc     1800

agcatcaaac agctgcagca ggagtgtgag cagctgcaga agatgtacgg ggggcagatt     1860

gatgaaagaa ccctggagaa gacccagcag cagcatatgt tataccagca ggagcagcac     1920

catcaaattc tccagcaaca aattcaagac tctatctgtc ctcctcagcc atctccacct     1980

cttcaggctg catgtgaaaa tcagccagcc ctccttaccc atcagctcca gaggttaagg     2040

attcagcctt caagcccacc ccccaaccac cccaacaacc atctcttcag gcagcccagt     2100

aatagtcctc cccccatgag cagtgccatg atccagcctc acggggctgc atcttcttcc     2160

cagtttcaag gcttaccttc ccgcagtgca atctttcagc agcaacctga gaactgttcc     2220

tctcctccca acgtggcact aacctgcttg ggtatgcagc agcctgctca gtcacagcag     2280

gtcaccatcc aagtccaaga gcctgttgac atgctcagca acatgccagg cacagctgca     2340

ggctccagtg ggcgcggcat ctccatcagc cccagtgctg gtcagatgca gatgcagcac     2400

cgtaccaacc tgatggccac cctcagctat gggcaccgtc ccttgtccaa gcagctgagt     2460

gctgacagtg cagaggctca cagtgcacat cagcagccgc cacactatac cacgtcggca     2520

ctacagcagg ccctgctgtc tcccacgccg ccagactata caagacacca gcaggtaccc     2580

cacatccttc aaggactgct ttctccccgg cattcgctca ccggccactc ggacatccgg     2640

ctgcccccaa cagagtttgc acagctcatt aaaaggcagc agcaacaacg gcagcagcag     2700

cagcaacagc agcaacagca agaataccag gaactgttca ggcacatgaa ccaaggggat     2760

gcggggagtc tggctcccag ccttggggga cagagcatga cagagcgcca ggctttatct     2820

tatcaaaatg ctgactctta tcaccatcac accagccccc agcatctgct acaaatcagg     2880

gcacaagaat gtgtctcaca ggcttcctca cccaccccgc cccacgggta tgctcaccag     2940

ccggcactga tgcattcaga gagcatggag gaggactgct cgtgtgaggg ggccaaggat     3000

ggcttccaag acagtaagag ttcaagtaca ttgaccaaag gttgccatga cagccctctg     3060

ctcttgagta ccggtggacc tggggaccct gaatctttgc taggaactgt gagtcatgcc     3120

caagaattgg ggatacatcc ctatggtcat cagccaactg ctgcattcag taaaaataag     3180

gtgcccagca gagagcctgt catagggaac tgcatggata gaagttctcc aggacaagca     3240

gtggagctgc cggatcacaa tgggctcggg tacccagcac gcccctccgt ccatgagcac     3300

cacaggcccc gggccctcca gagacaccac acgatccaga acagcgacga tgcttatgta     3360

cagctggata acttgccagg aatgagtctc gtggctggga aagcacttag ctctgcccgg     3420

atgtcggatg cagttctcag tcagtcttcg ctcatgggca gccagcagtt tcaggatggg     3480

gaaaatgagg aatgtggggc aagcctggga ggtcatgagc acccagacct gagtgatggc     3540

agccagcatt taaactcctc ttgctatcca tctacgtgta ttacagacat tctgctcagc     3600

tacaagcacc ccgaagtctc cttcagcatg gagcaggcag gcgtgtaaca agaaacagag     3660

agttttgtgt acagcttggg aatgaaaagg ttgattgtaa                           3700


<210> 4376
<211> 3495
<212> DNA
<213> Homo sapiens

<400> 4376
ctccccgaac tgcggcggcg gcgagcgccg gccgcatctg agcagagctg cagcggcggc       60

cgcgggcacc agagtgccga gcccaggacg cccccggccc aggcccttgg gttaatacct      120

ctgccaaccg aggccaccct ccctcggacc cccattcgga ggaagcagac ccaagttcga      180

attctgacat tgccactgag cagccgtaca acttttgggt ggacaagtcc ttcacttctc      240

gccggagtgt gtggaggagc gatgggcaga accagcactt ccctcaggca ctagacctgt      300

cacgagtgaa cttagttccc tcctatactc cttcactcta ccctaagaac acagatctat      360

ttgagatgat tgagaagatg cagggaagca ggatggatga acaacgctgc tccttcccgc      420

cgcccctcaa aacagaggag gactacattc catacccgag cgtgcacgag gtcttggggc      480

gagaaggacc cttccccctc atcctgctgc cccagtttgg gggctactgg attgagggca      540

ccaaccacga aatcaccagc atccccgaga cagagccact gcagtcgccc acaaccaagg      600

tgaagctcga gtgcaacccc acagcccgca tctaccggaa gcactttctc ggcaaggagc      660

atttcaatta ctactcactg gacgctgccc tcggccacct tgtcttctca ctcaagtacg      720

atgtcatcgg ggaccaagag cacctgcggc tgctgctcag gaccaagtgc cggacatacc      780

atgatgtcat ccccatctcc tgcctcaccg agttccctaa tgttgtccag atggcaaagt      840

tggtgtgtga agacgtcaat gtggatcggt tctatcctgt gctctacccc aaggcttccc      900

ggctcatcgt cacctttgac gagcatgtca tcagcaataa cttcaagttt ggcgtcattt      960

atcagaagct tgggcagacc tccgaggaag aactcttcag caccaatgag gaaagtcccg     1020

ctttcgtgga gttccttgaa tttcttggcc agaaggtcaa actgcaggac tttaaggggt     1080

tccgaggagg cctggacgtg acccacgggc agacggggac cgaatctgtg tactgcaact     1140

tccgcaacaa ggagatcatg tttcacgtgt ccaccaagct gccatacacg gaaggggacg     1200

cccagcagtt gcagcggaag cggcacatcg ggaacgacat cgtggctgtg gtcttccagg     1260

atgagaacac tcctttcgtg cccgacatga tcgcgtccaa cttcctgcat gcctacgtcg     1320

tggtgcaggc tgagggcggg ggccctgatg gccccctcta caaggtctct gtcactgcaa     1380

gagatgatgt gcccttcttt ggaccccccc tcccggaccc cgctgtgttc aggaaggggc     1440

ctgagttcca ggaatttttg ctgacaaagc tgatcaatgc tgaatatgcc tgctacaagg     1500

cagagaagtt tgccaaactg gaggagcgga cgcgggccgc cctcctggag acgctctatg     1560

aggaactaca catccacagc cagtccatga tgggcttggg cggcgacgag gacaagatgg     1620

agaatggcag tgggggcggc ggcttctttg agtctttcaa gcgggtcatc cggagccgca     1680

gccagtccat ggatgccatg gggctgagca acaagaagcc caacaccgtg tccaccagcc     1740

acagcgggag cttcgcgccc aacaaccccg acctggccaa ggcggctgga atatcattgc     1800

ttattcctgg gaaaagtgcg agtagattcg gacgccgggg cagtgccata ggcataggaa     1860

ccgtggaaga gtcactgatt gtccctggga agagccccac gaggaagaag tcgggcccgt     1920

tcggctcccg ccgcagcagc gccattggca tcgagaacat acaggaggtg caggagaaga     1980

gggagagccc tccggctggt cagaagaccc cagacagcgg gcacgtctca caggagccca     2040

agtcggagaa ctcatccact cagagctccc cagagatgcc cacgaccaag aacagagcgg     2100

agaccgcagc gcagagagca gaggcgctca aggacttctc ccgctcctcg tccagtgcca     2160

gcagcttcgc cagcgtggtg gaggagacgg agggtgtgga cggagaggac acaggcctgg     2220

agagcgtgtc atcctcagga acaccccaca agcgggactc cttcatctat agcacgtggc     2280

tggaggacag tgtcagcacc actagtgggg gcagctcccc agacgccggc aagttggggg     2340

accctgcgtg tcccgagatc aagatccagc tggaagcatc tgagcagcac atgccccagc     2400

tgggctgtta gccgggccac cccctctgaa ggtgaaactg agcagatgag gccacagaag     2460

cacaagggga aggtgccgtg tcaagcccag gcagacgaga cctctgccct gaagaccaac     2520

accagcccgt gggctgcccc ctgcctcccc accctcccca tggcccaccc atctgggctg     2580

tctctgcagg gcagagccgt ccagacctgg gatcagggaa gctgctggca tcgtccccac     2640

ccccagcctg ggggtctggg ctggggcagg gattgctcag tggaagcagg actgggggtc     2700

tggcttgccc cctccctggg cctccatcac ccctgagcat ccctctggac tcagagggaa     2760

caaggtggga gagagagttt gagacagctc cgtgtggaga gcttagcccc tggaggcagc     2820

acaaggagga tgtgatatgt gggggagtga gcactgggtt gggagccggg tcctggtttc     2880

caatttgggt tctgctgtgt gactctgggc aagtcactct ccctctctgg gcatgtctgc     2940

tacaaatgga caagattatt tcagaggtca ctgaagactg tgattacatg cacctgcctt     3000

agaaggtagg attttcttcc cagggacctc ctatcaccct accctgcttc ttgaggtccc     3060

tggagcccca ggtgggctga ggggcaggga gccggctgtg cccagtatgc ctcctggacc     3120

ctccagttct gccacaggtc tgccgatgcc ctgtccactg cctacacatg acagacaagt     3180

aaccccctca tgggggatgg ggacctacct ggctcctcag ccagcaccca gcttaacccc     3240

tgccatccca tgctgggccc tccaggccaa gagtctcagc tggccgagag tccaggcctt     3300

gcctcccccg accgccatgg agggggcagc ccggcacagc tgctgggagc ccttgtgtgt     3360

ctggtcacac tttttaggcg tcacgccaaa ggccagcctc ctggccccaa tacccatttt     3420

ggaagcccct gtggccgtgt ggatgtcggt aacagttgta taaaataaat tctatttatc     3480

gctattgtac ccaga                                                      3495


<210> 4377
<211> 2381
<212> DNA
<213> Homo sapiens

<400> 4377
aaagtctgta tactttttgg ttgggcagat ctccaccggc cctcaatctg attggccctc       60

gagctgtgga tgtgctgtct gagttgtcct atgcccctat gactccagac cacttcccaa      120

gcctcttttg caagtggcaa ccacagctga gtgaaacaaa ctgtaaccga atgaaagcaa      180

tgacaacgga atcctcccca ggaagctgct gattagagag ggccaaacgg acagacatct      240

tggccacctg taacgagcaa cttccaggag atgagtgtgg gctatgcaaa tgggatccgg      300

gtgatgagca tgacgcacac aggagagcca ggattcatgc tctacatccc catagagtac      360

gccctgcatg tatacaatga agtgatgagt gttggccaga aatacggaat ccggaatgct      420

gggtattacg ctcttcgcag tctccgaatt gagaagtttt ttgccttctg gggtcaggat      480

ataaataacc tcaccacgcc cctggaatgt ggacgagagt ctcgggtgaa attagagaag      540

ggcatggatt tcattggtcg cgacgccctc ctgcagcaga agcagaatgg agtgtataaa      600

cgcctcacca tgttcatcct ggacgaccat gattcagacc tagacctttg gccttggtgg      660

ggagagccca tttaccggaa tgggcagtat gttggcaaga ccaccagcag tgcctacagc      720

tacagcctgg agcgccacgt ttgcctgggc tttgtgcaca atttttctga ggacacgggg      780

gaagagcaag tggtgacagc agatttcatc aaccggggag agtatgagat tgacatcgcg      840

ggataccgct tccaggccaa ggccaagctc taccctgtcg cctccctctt cacccagaag      900

cgccgaaagg atgacatgga gctgagtgac ttacatggga agtgatgcca ccagggcagc      960

ctcacctcct ccccatcatc ttgtcctaga gtgggcgtca ccttggagct tctcttcctt     1020

ccgcctctgt tcctcttctg gagcctttgc ctcccatctc ttatctcctt gatataattt     1080

tgaacttgac ctactttaaa cttttttgct ctgcagcctt ccttgccctt ccacctcctc     1140

ctcctaatat tcactctggg ctcttcttcc cttcccaccc ctcactcagc ttctcgtggt     1200

ggcaggaggt atgtctgaca ggacagaagc aagctccact gtggacatga gtgatggtga     1260

cagctgcttt caaattctgc atctcaaggc agggcaagcc ggggtggtgc aggtctcagg     1320

gcacgagtcc ctctcccttg ggttccattt tcttggagca gcctattagt tctggtgggg     1380

ttgccgtgtg tcggatgcag ccctgagggg cagctcgtgc ctgcagcccg gcagctcgtt     1440

ctcctgttct gctgtgctgt gggctggcac tcgatacctc tggcaagagg atgattatct     1500

acctcactga taagaggcat cgcatggacg ttctctggtc tgtagtggag acaagcagtt     1560

aacctagcac catcctcatc ctccctgcag aagccattag cagacctttg ggccagggca     1620

gcctccctat aattttcttc atctcttgct aatctctata ataaggttgc tttttctttc     1680

ttagttgagt aaacaagtaa gccacagtgt ttgaaaggga aaaaccatat tgccttgtgt     1740

gttgcttttc ccagtcaaaa gggtctgacc ttagaaagtc cccaccagtg atgctgagtg     1800

ttctgctatg gaaacaatgc tgcttttctc tcagctgtcc aaagttcagc cgttcctcct     1860

tccccttctc ccagtgcgtt tgactttgtc aggtcagcct cacttgtccc tttcacagtt     1920

ggcccataaa gtcatgtttc tctcccttta gaatagggag gggaagggat caggtgtgtt     1980

gtcctgggcc tttcaacctt gcgggctgtg ctgagttcca gagagctgcc ggaattccag     2040

gtttgactct ccagcacaga gcagagctac acagaggtga cccacgttag tccactgaga     2100

gttctgagtc caaagggtgt acgttgcata aggctagaga ccgcttttcc tcctttcccc     2160

ccaggctctt tgtttccctc cacccaccct tccatatcct ctggagcagg agacaatgtg     2220

ggtgcccaga agtgccctgc gctttcaggc agtgtctctg ttttcccaag gtgaaactta     2280

gatatcatgg actgttgtcc agcctcaatg cttcattttc cccttgcata tcaactgccc     2340

taatctgact ttttttaagt gcaaataaac tgctataaga c                         2381


<210> 4378
<211> 1862
<212> DNA
<213> Homo sapiens

<400> 4378
acttctcttc ttccgcgacc gggagaaggc cgagggatcg gcggcacgat cgacattgta       60

caccttgaag gtggacggat gtgaagccgc gcgttgtagg gctgaagctt accaaagaaa      120

ggaagaatgc acttttcagg attagaagag gctgtgtata gaaacataca agcttgcaag      180

gagcttgccc aaaccactcg tacagcatat ggaccaaatg gaatgaacaa aatggttatc      240

aaccacttgg agaagttgtt tgtgacaaac gatgcagcaa ctattttaag agaactagaa      300

gtacagcatc ctgctgcaaa aatgattgta atggcttctc atatgcaaga gcaagaagtt      360

ggagatggca caaactttgt tctggtattt gctggagctc tcctggaatt agctgaagaa      420

cttctgagga ttggcctgtc agtttcagag gtcatagaag gttatgaaat agcctgcaga      480

aaagctcatg agattcttcc taatttggta tgttgttctg caaaaaacct tcgagatatt      540

gatgaagtct catctctact tcgtacctcc ataatgagta aacaatatgg taatgaagta      600

tttctggcca agcttattgc tcaggcatgc gtatctattt ttcctgattc cggccatttc      660

aatgttgata acatcagagt ttgtaaaatt ctgggctctg gtatcagttc ctcttcagta      720

ttgcatggca tggtttttaa gaaggaaacc gaaggtgatg taacatctgt caaagatgca      780

aaaatagcag tgtactcttg tccttttgat ggcatgataa cagaaactaa gggaacagtg      840

ttgataaaga ctgctgaaga attgatgaat tttagtaagg gagaagaaaa cctcatggat      900

gcacaagtca aagctattgc tgatactggt gcaaatgtcg tagtaacagg tggcaaagtg      960

gcagacatgg ctcttcatta tgcaaataaa tataatatca tgttagtgag gctaaactca     1020

aaatgggatc tccgaagact ttgtaaaact gttggtgcta cagctcttcc tagattgaca     1080

cctcctgtcc ttgaagaaat gggacactgt gacagtgttt acctctcaga agttggagat     1140

actcaggtgg tggtttttaa gcatgaaaag gaagatggcg ccatttctac catagtactt     1200

cgaggctcta cagacaatct gatggatgac atagaaaggg cagtagacga tggtgttaat     1260

actttcaaag ttcttacaag ggataaacgt cttgtacccg gaggtggagc aacagaaatt     1320

gaattagcca aacagatcac atcatatgga gagacatgtc ctggacttga acagtatgct     1380

attaagaagt ttgctgaggc atttgaagct attccccgcg cactggcaga aaactctgga     1440

gttaaggcca atgaagtaat ctctaaactt tatgcagtac atcaagaagg aaataaaaac     1500

gttggattag atattgaggc tgaagtccct gctgtaaagg acatgctgga agctggtatt     1560

ctagatactt acctgggaaa atattgggct atcaaactcg ctactaatgc tgcagtcact     1620

gtacttagag tggatcagat catcatggca aaaccagctg gtgggcccaa gcctccaagt     1680

gggaagaaag actgggatga tgaccaaaat gattgaaatt ggcttaattt ttactgtagg     1740

tgaaggctgt atttgtagta gtactcaaga atcacctgat gttttcttat tctccttaaa     1800

ttaagagtta ttttgtgttt gtattcttgg ctggatgtta taataaacat attgttactg     1860

tc                                                                    1862


<210> 4379
<211> 3110
<212> DNA
<213> Homo sapiens

<400> 4379
acgtcgttgg gacatcgctg ggaccccggg ctctgcagcc acaaccatgt ttggccggaa       60

gcgcagtgtc tcctttgggg gcttcggatg gatcgacaag accatgctgg caagtctgaa      120

ggtcaagaag caggagctgg ccaacagctc ggatgcgacc ctcccagacc ggccgctctc      180

ccctcctctc acggcacctc ccaccatgaa gtcgtcggag ttctttgaga tgctggagaa      240

aatgcagggg atcaagcttg aagagcagaa gccgggaccc cagaagaaca aggacgacta      300

tatcccatac cccagcatcg acgaggttgt ggagaaggga ggcccgtacc ctcaggtcat      360

cctgccacag tttgggggct attggatcga ggacccggag aacgtgggca ccccaacatc      420

gctggggagc agcatctgtg aggaggagga agaggacaac ctcagcccca acacatttgg      480

ctacaagctc gagtgcaagg gtgaagccag ggcctaccgg aggcacttcc tggggaagga      540

tcatctaaac ttttactgta ccggcagcag cctggggaac ttgatcctgt ccgtcaagtg      600

cgaggaagca gaggggatcg agtacctccg ggtcatcctt aggtccaaac tgaagacggt      660

acatgagcgg atccccttgg ctggactgag caagcttccc agtgtccctc agattgcaaa      720

ggctttctgt gatgatgcag tgggactgag attcaatcct gtcctgtacc ccaaggcctc      780

ccaaatgatt gtgtcctatg atgagcatga agtcaacaac acattcaaat tcggagtcat      840

ttatcaaaaa gccaggcaga ccctggagga ggagctattt gggaacaatg aggagagccc      900

agcttttaag gagttcttgg acctgctggg ggacacgatc acactgcagg atttcaaagg      960

tttccgagga ggcctggacg tgacccacgg acagacaggg gtggaatcag tgtacacaac     1020

attccgggac agggagatca tgtttcacgt ttccacaaag ctgccattta ccgacggaga     1080

cgcccagcag ctccagagaa agagacacat tggaaatgac atcgtggcca tcatcttcca     1140

agaggaaaac acgccgtttg tcccagacat gatagcctcc aatttcttac atgcctacat     1200

cgtcgtgcag gtcgagaccc caggcacaga gaccccatcc tacaaggtct ctgtcactgc     1260

gcgggaagat gtgcccacct ttggtccacc tctgcccagt ccccccgttt tccagaaggg     1320

cccggaattc agggagtttc tgctcaccaa gctcaccaat gccgagaacg cctgctgcaa     1380

gtcggacaag tttgcaaagc tggaggaccg gaccagggct gccctcctgg acaaccttca     1440

cgatgagctc cacgcccaca cacaggccat gctgggactg ggcccagagg aggacaagtt     1500

tgagaatgga ggccacgggg ggttcctgga gtcttttaag agggccatcc gcgtacgcag     1560

ccactccatg gagaccatgg tgggcggcca gaagaagtcg cacagtgggg gcatccctgg     1620

cagcctcagc gggggcatct cccacaacag catggaggtc accaagacca ccttctcgcc     1680

tccagtggtg gcggcaacgg tgaagaacca gtcacggagt cccatcaagc gacgctcggg     1740

gctcttcccc cgcctgcaca cgggctcaga aggccagggc gacagccggg cacgatgtga     1800

cagcacatcc agcacaccca agaccccaga tggtggacac tcctctcagg agataaagtc     1860

tgagacctca tccaatccca gctctccgga aatctgcccc aacaaggaga agcccttcat     1920

gaagttgaag gaaaacggcc gtgccatctc ccgctcctcc tccagcacca gcagcgtcag     1980

cagcactgca ggggagggcg aggccatgga ggagggcgac agtgggggca gccagccgtc     2040

cacgacctca cccttcaagc aggaggtgtt tgtctacagc ccgtccccga gcagcgagag     2100

ccccagcctg ggggcagctg ccaccccgat catcatgagc cggagtccca cagatgccaa     2160

aagcagaaac tccccgagat cgaacctgaa attccgcttt gacaagctca gccatgccag     2220

ctctggtgcg ggtcactaat gtgaaagtgg agtccttcgc ctgtccaagg gaatcccctc     2280

ttctgtcctg gaaaaggctc ctgtaccagc agtttgggag tgccgtccac gaccctgaca     2340

gtcccagccc tgctgcccca tggccacgtg cccacagatg tgctgttggt ccaggtgtcc     2400

cagtctggcc acagccctgc ctccgccctc acctacatgc cctcccagcc cctcccatct     2460

ctggacgagg cctccttcct caggttcctc ctgctcctga cctcccagtg tgatgtccgg     2520

gtcctttatc atcctattca tcctggagag gaaaagtgtc gggcaaaggg ggatctgggg     2580

ggagctcagc agtgactggg gagctggtct gcctcagaga cagagtaggg ggtgggagca     2640

gagcctcggt gagggtcttg gccacagggc agtgccttcc tgaacgtggc aggctttact     2700

accaggaacg cactcggtgg tggaggcccc atgttcccag gagccaagat tcgtagcatc     2760

cttgaggcca tcctgataaa attcggcgct attgcccccg tagctctgga gctctaaacc     2820

gtctatctgc ttctgtgctg aacgcctttc ccatctgctg acgtaggccc agggctgccc     2880

tgcccctgct gccagtgtac cgtgagcggg gctccagcca gttcaagctc agagccagag     2940

ctggacgggc cagaactgcg ctgcacactt cctggactga ggcggggact ttgggtccca     3000

cccggtttct cctgattatg gctgctgtgg ggtgagggga gggaggggca gccccgaggc     3060

agtctcttcc ctttgagaag atattttccc ccttccgagt ctgcagcgcc                3110


<210> 4380
<211> 2288
<212> DNA
<213> Homo sapiens

<400> 4380
agttggcgac atggtggcac ccgtgctgga gacttctcac gtgttttgct gcccaaaccg       60

ggtgcgggga gtcctgaact ggagctctgg gcccagagga cttctggcct ttggcacgtc      120

ctgctccgtg gtgctctatg accccctgaa aagggttgtt gttaccaact tgaatggtca      180

caccgcccga gtcaattgca tacagtggat ttgtaaacag gatggctccc cttctactga      240

attagtttct ggaggatctg ataatcaagt gattcactgg gaaatagagg ataatcagct      300

tttaaaagca gtgcatcttc aaggccatga aggacctgtt tatgcggtgc atgctgttta      360

ccagaggagg acatcagatc ctgcattatg tacactgatc gtttctgcag ctgcagattc      420

tgctgttcga ctctggtcta aaaagggtcc agaagtacca atattagcat gtggcaatga      480

tgattgcaga attcacatat ttgctcaaca aaatgatcag tttcagaaag tgctttctct      540

ctgtggacat gaggattgga ttagaggagt ggaatgggca gcctttggta gagatctttt      600

cctagcaagc tgttcacaag attgcctgat aagaatatgg aagctgtata taaagtcaac      660

atctttagaa actcaggatg acgataacat aagactgaaa gaaaatactt ttaccataga      720

aaatgaaagt gttaaaatag catttgctgt tactctggag acagtgctag ccggtcatga      780

aaactgggta aatgcagttc actggcaacc tgtgttttac aaagatggtg tcctacagca      840

gccagtgaga ttattatctg cttccatgga taaaaccatg attctctggg ctccagatga      900

agagtcagga gtttggctag aacagagaga gtggactcca gagattgtca tttcaggaca      960

ctttgatggt gtccaagacc tagtctggga tccagaagga gaatttatta tcactgttgg     1020

tactgatcag acaactagac tttttgctcc atggaagaga aaagaccaat cacaggtgac     1080

ttggcatgaa attgcaaggc ctcagataca tgggtatgac ctgaaatgtt tggcaatgat     1140

taatcggttt cagtttgtat ctggagcaga tgaaaaagtt cttcgggttt tttctgcacc     1200

tcggaatttt gtggaaaatt tttgtgccat tacaggacaa tcactgaatc atgtgctctg     1260

taatcaagat agtgatcttc cagaaggagc cactgtccct gcattgggat tatcaaataa     1320

agctgtcttt cagggagata tagcttctca gccttctgat gaagaggagc tgttaactag     1380

tactggtttt gagtatcagc aggtggcctt tcagccctcc atacttactg agcctcccac     1440

tgaggatcat cttctgcaga atactttgtg gcctgaagtt caaaaactat atgggcacgg     1500

ttatgaaata ttttgtgtta cttgtaacag ttcaaagact ctgcttgcct cagcttgtaa     1560

ggcagctaag aaagagcatg cagctatcat tctttggaac actacatctt ggaaacaggt     1620

gcagaattta gttttccaca gtttgacagt cacgcagatg gccttctcac ctaatgagaa     1680

gttcttacta gctgtttcca gagatcgaac ctggtcattg tggaaaaagc aggatacaat     1740

ctcacctgag ttcgagccag tttttagtct ttttgccttc accaacaaaa ttacttctgt     1800

gcacagtaga attatttggt cttgtgattg gagtcctgac agcaagtatt tcttcactgg     1860

gagtcgagac aaaaaggtgg ttgtctgggg tgagtgcgac tccactgatg actgtattga     1920

gcacaacatt ggcccctgct cctcagtcct ggacgtgggt ggggctgtga cagctgtcag     1980

cgtctgccca gtgctccacc cttctcaacg atacgtggtt gcagtaggat tggagtgtgg     2040

aaagatttgc ttatatacct ggaaaaagac tgatcaagtt ccagaaataa atgactggac     2100

ccactgtgta gaaacaagtc aaagccaaag tcatacactg gctatcagaa aattatgctg     2160

gaagaattgc agtggaaaaa ctgaacagaa ggaagcagaa ggtgctgagt ggttacactt     2220

tgcaagctgt ggtgaagatc acactgtgaa gatacacaga gtcaataaat gtgcactgta     2280

atggactt                                                              2288


<210> 4381
<211> 1504
<212> DNA
<213> Homo sapiens

<400> 4381
acattcccac aggaaacaag tcgaccttct gtagcaaagc agcttcttgc cgggactccg       60

caaagctgaa agaggtagac aaagccaacc tcacagtaaa agcagagtgc agcagacaac      120

agtttcatcc agattaaaaa tgaaccggca gcctgtgaaa gaccgcaagg caccatggat      180

acccccaaac cccacatccc caccagcgtc tcctaaatgt gctgcatggc taaaggtgaa      240

aactagcccc agagatgcca caaaagagcc tctccagcaa gaagatcctc aagaggaaag      300

tcacctgaca ggtgctgttg agcatgaagc agccaggctc gcttggcttg atgctgaaac      360

ttccaaaaga ttgaaggaac tagaagagtt aaaagccaag gaaattgaca gcatgcaaaa      420

acagaggctt gattggcttg atgctgaaac ttctagaaga acaaaggaac tgaatgagct      480

caaagctgaa gaaatgtata gactccaaca attgagtgtt tctgccaccc acttagcaga      540

caaggtagag gaggcagttc tggatcgttt gaagcctctc ttggtcaagg cccagagagt      600

caattctact acagaagcaa atattcattt gaaagatggc tcgtcagtaa acacagcgaa      660

agcccagcct gcacaggagg ttgcagctgt tgattttgaa tccaacaaca ttcgtcagct      720

tgatgatttt ttggaagatt gtgccagtga gctctgggct gtgactcatg ctaagatctt      780

ggggtctgaa accttagcca ccgttgagga cagcaaggat agcccagatc tggagatcat      840

gatgcgccga atggaagaga tggaaaaata ccaggagtct gttcgtcaaa gatataataa      900

aatcgcatat gctgatcctc gactttggat gcaggaagaa aacaatgacc aaaaaatctc      960

agcaataagt gaaaagcctc tatctcctca tccaatcaga atcacgaaga cagtggatcg     1020

caaggatcca gccgtgaaca tcatgttaga aaggccctgt aatggcaatt ccctggatga     1080

aagtgtggga acagaggaag gatcagagaa aagagaggcc cctcttctct ccctagccga     1140

agattctcaa cagaaagaag gccgagctcc cctctttgtc ccaccgggta tgcagcacag     1200

catcggtgac tactgtagtc gttttgagca gtaccttcgg atcatatctc atgaggctgt     1260

aggctccttc aacccgtggc tgatagctga aagcttttca gaagagctgg tagatgaagc     1320

tctgggtgct gtggctgctg aacttcagga tatgtgcgaa gattatgcag aagctgtgtt     1380

cacctcagaa ttcttagagg ctgctacata aaggctctct gaggcgaggc catttgtgtc     1440

acactggaga agggatggca ccaccctttg ttttggccca caggaaattt tcatcctcag     1500

ctgt                                                                  1504


<210> 4382
<211> 1165
<212> DNA
<213> Homo sapiens

<400> 4382
agccaaggga accacatgga agttgtgaca gctcccagcg gcgcgcccct ttcgtgtgtg       60

ccggtacctc ggcttaggag ttgcccgctg acaccttgaa tgaaggaggt ccccttgcca      120

gccagcctgc cgggatgggc cattgctgct gcaagcctta taactgcctt cagtgcctgg      180

acaagacgcc ttccatacag caaagtgcga gaaactacaa aaggagaagg aggagctgga      240

gaggcggttc gaggacgagg tgaagaggct gggctggcag cagcaggccg agctccagga      300

gctggaggag cggctgcagc tgcaattcga ggcggaaatg gcgcgcctgc aggaggagca      360

cggtgaccag ctgctgagca tccggtgtca acaccaggag caggtggaag atctcaccgc      420

cagccatgat gctgctctcc tagagatgga aaataaccac acagttgcca tcacaatcct      480

gcaggatgac cacgaccaca aagtccaaga attgatgtcc actcatgagc ttgaaaagaa      540

agaattggaa gaaaattttg aaaaactgcg gctgtcattg caggaccagg tggacacgct      600

gaccttccag agccagtctc tgcgggacag agcccgccgc ttcgaagagg ccttgaggaa      660

gaacacagag gagcagctgg agattgcatt ggctccttat cagcacttgg aagaagacat      720

gaagagtctg aagcaggtat tagaaatgaa gaatcagcaa atacacgagc aagaaaagaa      780

gattcttgag ctggaaaagc tggcagaaaa gaacattatc ctagaagaaa agatccaggt      840

tctccaacag cagaacgaag acctcaaagc aaggattgac caaaacacag ttgtcaccag      900

acagctgtcg gaggaaaatg ctaacctcca ggaatatgtt gagaaggaaa cccaggagaa      960

gaagagattg agccgaacca atgaagagct gctttggaag ctccaaactg gggacccgac     1020

cagtccgatt aaactctcgc ccacatctcc cgtttaccgc ggctcctcct cggggccctc     1080

ctctccggcc agagtcagca caacacccag atgacgccac tacacggcct gcgggagctc     1140

cggcttctcg tcctccggtc tccac                                           1165


<210> 4383
<211> 1481
<212> DNA
<213> Homo sapiens

<400> 4383
agctctgggt gctccagctg ggccacagcc tggtcctgcc gctgcgcccg cccgccatgg       60

tgtcccggga ccaggctcac ctgggcccca agtatgtggg cctctgggac ttcaagtccc      120

ggacggacga ggagctgagc ttccgcgcgg gggacgtctt ccacgtggcc aggaaggagg      180

agcagtggtg gtgggccacg ctgctggacg aggcgggtgg ggccgtggcc cagggctatg      240

tgccccacaa ctacctggcc gagagggaga cggtggagtc ggaacctgcg ggacacgcag      300

gctgtgcggc actacaagat ctggcggcgt gccgggggcc ggctgcacct gaacgaggcg      360

gtgtccttcc tcagcctgcc cgagcttgtg aactaccaca gggcccagag cctgtcccac      420

ggcctgcggc tggccgcgcc ctgccggaag cacgagcctg agcccctgcc ccattgggat      480

gactgggaga ggccgaggga ggagttcacg ctctgcagga agctggggtc cggctacttt      540

ggggaggtct tcgaggggct ctggaaagac cgggtccagg tggccattaa ggtgatttct      600

cgagacaacc tcctgcacca gcagatgctg cagtcggaga tccaggccat gaagaagctg      660

cggcacaaac acatcctggc gctgtacgcc gtggtgtccg tgggggaccc cgtgtacatc      720

atcacggagc tcatggccaa gggcagcctg ctggagctgc tccgcgactc tgatgagaaa      780

gtcctgcccg tttcggagct gctggacatc gcctggcagg tggctgaggg catgtgttac      840

ctggagtcgc agaattacat ccaccgggac ctggccgcca ggaacatcct cgtcggggaa      900

aacaccctct gcaaagttgg ggacttcggg ttagccaggc ttatcaagga ggacgtctac      960

ctctcccatg accacaatat cccctacaag tggacggccc ctgaagcgct ctcccgaggc     1020

cattactcca ccaaatccga cgtctggtcc tttgggattc tcctgcatga gatgttcagc     1080

aggggtcagg tgccctaccc aggcatgtcc aaccatgagg ccttcctgag ggtggacgcc     1140

ggctaccgca tgccctgccc tctggagtgc ccgcccagcg tgcacaagct gatgctgaca     1200

tgctggtgca gggaccccga gcagagaccc tgcttcaagg ccctgcggga gaggctctcc     1260

agcttcacca gctacgagaa cccgacctga gctgctgtgg agcgggcatg gccgggccct     1320

gctgaggagg ggcctgggca gagggcctgg acctgggatc aaggcccacg cgcttccctg     1380

gggtttactg aggtgatggg tgcaggaaag gttcacaaat gtggagtgtc tgcgtccaat     1440

acacgcgtgt gctcctctcc ttactccatc gtgtgtgcct t                         1481


<210> 4384
<211> 5541
<212> DNA
<213> Homo sapiens

<400> 4384
gctgctgctg cagtgggaca ggtggcggcg accggcggcg tccgaggaga tttaatccag       60

agactgactt cactatagaa cccacagttg tatcaatggt tggggaaaga tagtggcaac      120

aggcaaagga gaaacagctc tgacatacaa agaaaatgag tatgctaaag ccaagtgggc      180

ttaaggcccc caccaagatc ctgaagcctg gaagcacagc tctgaagaca cctacggctg      240

ttgtagctcc agtagaaaaa accatatcca gtgaaaaagc atcaagcact ccatcatctg      300

agactcagga ggaatttgtg gatgactttc gagttgggga gcgagtttgg gtgaatggaa      360

ataagcctgg atttatccag tttcttggag aaacccagtt tgcaccaggc cagtgggctg      420

gaattgtttt agatgaaccc ataggcaaga acgatggttc ggtggcagga gttcggtatt      480

tccagtgtga acctttaaag ggcatattta cccgaccttc aaagttaaca aggaaggtgc      540

aagcagaaga tgaagctaat ggcctgcaga caacgcccgc ctcccgagct acttcaccgc      600

tgtgcacttc tacggccagc atggtgtctt cctccccctc caccccttca aacatccctc      660

agaaaccatc acagccagca gcaaaggaac cttcagctac gcctccgatc agcaacctta      720

caaaaactgc cagtgaatct atctccaacc tttcagaggc tggctcaatc aagaaaggag      780

aaagagagct caaaatcgga gacagagtat tggttggtgg cactaaggct ggtgtagtcc      840

ggtttcttgg ggagaccgac tttgccaagg gggagtggtg tggcgtggag ttagatgagc      900

cacttgggaa gaatgatggc gctgttgctg gaacaaggta ttttcagtgt caacccaaat      960

atggcttgtt cgctcctgtc cacaaagtta ccaagattgg cttcccttcc actacaccag     1020

ccaaagccaa ggccaacgca gtgaggcgag tgatggcgac cacgtccgcc agcctgaagc     1080

gcagcccttc tgcctcttcc ctcagctcca tgagctcagt ggcctcctct gtgagcagca     1140

ggcccagtcg gacaggacta ttgactgaaa cctcctcccg ttacgccagg aagatctccg     1200

gtaccactgc cctccaggag gccctgaagg agaagcagca gcacattgag cagctgctgg     1260

cggaacggga tctggagagg gcggaggtgg ccaaggccac gagccacgtg ggggagatag     1320

agcaggagct agctctggcc cgggacggac atgaccagca tgtcctggaa ttggaagcca     1380

aaatggacca gctgcgaaca atggtggaag ctgctgacag ggagaaggtg gagcttctca     1440

accagcttga agaggagaaa aggaaggttg aggaccttca gttccgggtt gaagaagaat     1500

caattaccaa aggtgatctt gagacgcaga ccaaactgga gcatgcccgc attaaggagc     1560

ttgaacagag cctgctcttt gaaaagacca aagctgacaa actccagagg gagttagaag     1620

acactagggt ggctacagtt tcagaaaagt cacgtataat ggaactggag aaagacctag     1680

cattgagagt acaggaagta gctgagctcc gaagaaggct agagtccaat aagcctgctg     1740

gggatgtgga catgtcactt tcccttttgc aagagataag ctctttgcaa gaaaagttag     1800

aagtcacccg tactgaccac cagagagaaa taacttctct gaaggagcat tttggagccc     1860

gggaagaaac tcatcagaag gagataaagg ctctgtatac cgccacggaa aagctttcca     1920

aagagaacga gtcattgaaa agcaagctgg agcatgccaa caaagagaac tcagatgtga     1980

tagctctatg gaagtccaaa ctggagactg ccatcgcatc ccaccagcag gcgatggaag     2040

aactgaaggt atctttcagc aaagggcttg gaacagagac ggcagaattt gctgaactaa     2100

aaacacaaat agagaaaatg agactagatt accaacacga aatagaaaat ttgcagaatc     2160

aacaagactc tgaacgggct gcccatgcta aagagatgga agccttgagg gctaaactga     2220

tgaaagttat taaagaaaag gaaaacagtc tggaagccat caggtcgaaa ctggacaaag     2280

cagaagacca gcatctcgta gaaatggaag acacgttaaa caaattacag gaagctgaaa     2340

taaagaaaga aaagtttgct gaagcttcag aggaggcagt ctctgttcag agaagtatgc     2400

aagaaactgt aaataagtta caccaaaagg aggaacagtt taacatgctg tcttctgact     2460

tggagaagct gagagaaaac ttagcagata tggaggcaaa atttagagag aaagatgaga     2520

gagaagagca gctgataaag gcaaaggaaa aactggaaaa tgacattgca gaaataatga     2580

agatgtcagg agataactct tctcagctga caaaaatgaa cgatgaatta cgtctgaaag     2640

aaagagatgt agaagaatta cagctaaaac ttacaaaggc taatgaaaat gcaagttttc     2700

tgcaaaaaag tattgaggac atgactgtca aagctgaaca gagccagcaa gaagcagcta     2760

aaaagcatga ggaagaaaag aaagaattgg agaggaaatt gtcggacctg gaaaagaaaa     2820

tggaaacaag ccacaaccag tgtcaggagc tgaaagccag gtatgagaga gccacttctg     2880

agacaaaaac caagcatgaa gaaatcctac agaacctcca gaagacgctg ctggacacag     2940

aggacaagct gaagggcgca cgggaggaga acagtggctt gctgcaggag ctggaggagc     3000

tgagaaagca agccgacaaa gccaaagctg ctcaaacagc ggaagatgcc atgcagataa     3060

tggaacagat gaccaaagag aagactgaga ctctggcctc cttggaggac accaagcaaa     3120

caaatgcaaa actacagaat gaattggaca cacttaaaga aaacaacttg aaaaatgtgg     3180

aagagctgaa caaatcaaaa gaactcctga ctgtagagaa tcaaaaaatg gaagaattta     3240

ggaaagaaat agaaacccta aagcaggcag cagctcagaa gtcccagcag ctttcagcgt     3300

tgcaagaaga gaacgttaaa cttgctgagg agctggggag aagcagggac gaagtcacaa     3360

gtcatcaaaa gctggaagaa gaaagatctg tgctcaataa tcagttgtta gaaatgaaaa     3420

aaagagaatc caagttcata aaagacgcag atgaagagaa agcttccttg cagaaatcca     3480

tcagtataac tagtgcctta ctcacagaaa aggatgccga gctggagaaa ctgagaaatg     3540

aggtcacagt gctcagggga gaaaacgcct ctgccaagtc cttgcattca gttgttcaga     3600

ctctagagtc tgataaggtg aagctcgagc tcaaggtaaa gaacttggag cttcaactca     3660

aagaaaacaa gaggcagctc agcagctcct caggtaatac agacactcag gcagacgagg     3720

atgaaagagc ccaggagagt cagaatcaga ttgatttcct aaattcagta atagtggacc     3780

ttcaaaggaa gaatcaagac ctcaagatga aggtggagat gatgtcagaa gcagccctga     3840

atgggaacgg ggatgaccta aacaattatg acagtgatga tcaggagaaa cagtccaaga     3900

agaaacctcg cctcttctgt gacatttgtg actgctttga tctccacgac acagaggatt     3960

gtcctaccca ggcacagatg tcagaggacc ctccccattc cacacaccat ggcagtcggg     4020

gtgaggaacg cccatactgt gaaatctgtg agatgtttgg acactgggcc accaactgca     4080

atgacgacga aaccttctga tgaagcctcc agtggagaac tgggcttgct cagacgcact     4140

cgcattgaca caacgtaaca ccagcattgt gtgtgcagac ttcaggagaa ctcatgttat     4200

tttttaaccc cgtcaacaaa tctaggaaaa tattttgatc ttcaacaaat tgccctttag     4260

tctccccgta tgagttagaa taataaatat ttagtaggtg agttttcacc tcgaattttg     4320

ttttcttgat ttttacgttt gaagacattg caccagatgc cattacattt attggccccc     4380

cgaccttgta gaaaaacccc taccctcaca ataccttatt taagtaactt taaattatgc     4440

cgttactttt catatttgca ctaagatatt tccaggctgc atttgtatat ttagattttt     4500

tggttaagct ttgacactgg aatgagttga aaaaatgtgc cattttgcat tttcatctac     4560

tcatttaaag tattttattc ttattcaaag aaatatctga gctctttgca ctacctgtta     4620

tcagtagtgc ctttacttca ggcttgataa tacttaggtg tgattataaa atcatgaagc     4680

aggtaaaggg aggggcaagc ccccaaactg ctgtggggac attttataat ctatatgctg     4740

cacccactta atctactgtg gtgttttgtt tattagtttt gcataatttc agcttctata     4800

tattgtatgt atatattttt taaaaatcta tattttggga aaaaaacata cacaatgtgt     4860

ctttcttttt ggacatttac ctttttgaaa aagaaaacac ttaaaatgat cattaggaca     4920

taacagacta ggccagacat agcatcttgt ggctttgcaa ccattttcat ttgtttgttt     4980

tccttttatt tcttcaccag atttaaataa ctggaggaat tttctccaat ttttttttcc     5040

ttctctggca ggtatcccca gcagtcaatt aacaataagc cagtataaaa cacctaaata     5100

accaatctac aatctccctt cacaagtttt tttactgttt ttagatgaat gtacgatgag     5160

aaattcaacg ttaataattc tggattttct tatcacaaaa aagaaaatga aggacctcaa     5220

agcacctgaa cagtttatcg accagtttga atctatttat cttcatttga atgtcttcta     5280

gaatatgtaa aaagtcataa aatgtatctt ccatgctaca tgtacaataa gaacttctat     5340

aattgtatat atgcctttga tgtattttcc cctcaagatt atcaactgtg tgttcgacag     5400

tgaatattca atctggtacc agttgaaatt tttggttata aatgtaatac gaattgtttc     5460

acaaacagaa aacatgtaaa gcagtattaa aatttggcca aacaagtgtt ctgtatctac     5520

tttaataaat ggttattctt t                                               5541


<210> 4385
<211> 911
<212> DNA
<213> Homo sapiens

<400> 4385
tagttattaa agttcctatg cagctccgcc tcgcgtccgg cctcatttcc tcggaaaatc       60

cctgctttcc ccgctcgcca cgccctcctc ctacccggct ttaaagctag tgaggcacag      120

cctgcgggga acgtagctag ctgcaagcag aggccggcat gaccaccgag cagcgacgca      180

gcctgcaagc cttccaggat tatatccgga agaccctgga ccctacctac atcctgagct      240

acatggcccc ctggtttagg gaggaagagg tgcagtatat tcaggctgag aaaaacaaca      300

agggcccaat ggaggctgcc acactttttc tcaagttcct gttggagctc caggaggaag      360

gctggttccg tggctttttg gatgccctag accatgcagg ttattctgga ctttatgaag      420

ccattgaaag ttgggatttc aaaaaaattg aaaagttgga ggagtataga ttacttttaa      480

aacgtttaca accagaattt aaaaccagaa ttatcccaac cgatatcatt tctgatctgt      540

ctgaatgttt aattaatcag gaatgtgaag aaattctaca gatttgctct actaagggga      600

tgatggcagg tgcagagaaa ttggtggaat gccttctcag atcagacaag gaaaactggc      660

ccaaaacttt gaaacttgct ttggagaaag aaaggaacaa gttcagtgaa ctgtggattg      720

tagagaaagg tataaaagat gttgaaacag aagatcttga ggataagatg gaaacttctg      780

acatacagat tttctaccaa gaagatccag aatgccagaa tcttagtgag aattcatgtc      840

caccttcaga agtgtctgat acaaacttgt acagcccatt taaaccaatc aaaaaaaaaa      900

aaaaaaaaaa a                                                           911


<210> 4386
<211> 3576
<212> DNA
<213> Homo sapiens

<400> 4386
aagtgctcag caacgattac gccccgaggg ccaatcacag ggctgcggcc gagaaagaag       60

ccttaataga gctttctcaa cctgcagccc tcatctccgc cggcgagtag ggccaggtgt      120

tgggagctcc cacgtgggac aagatggtgt cttcggcgca gatgggcttc aacctgcagg      180

ctctcctgga gcagctcagc caggatgagt tgagcaagtt caagtatctg atcacgacct      240

tctccctggc acacgagctc cagaagatcc cccacaagga ggtagacaag gctgatggga      300

agcaactggt agaaatcctc accacccatt gtgacagcta ctgggtggag atggcgagcc      360

tccaggtctt tgaaaagatg caccgaatgg atctgtctga gagagcaaag gatgaagtca      420

gagaagcagc tttgaaatcc tttaataaaa ggaagcctct atcattaggg ataacacgga      480

aagaacgacc acctctagac gtggacgaaa tgctggagcg cttcaaaaca gaagcacaag      540

cgtttacaga aacgaaagga aatgtcatct gcctgggtaa agaagtcttt aaaggaaaaa      600

agccagacaa agacaatagg tgcaggtata tattgaagac gaagttccgg gagatgtgga      660

agagctggcc tggagatagc aaagaggtcc aggttatggc tgagagatac aagatgctga      720

tcccattcag caaccccagg gtgcttcccg ggcccttctc atacacggtg gtgctgtatg      780

gtcctgcagg ccttgggaaa accacgctgg cccagaaact aatgctagac tgggcagagg      840

acaacctcat ccacaaattc aaatatgcgt tctacctcag ctgcagggag ctcagccgcc      900

tgggcccgtg cagttttgca gagctggtct tcagggactg gcctgaattg caggatgaca      960

ttccacacat cctagcccaa gcacggaaaa tcttgttcgt gattgacggc tttgatgagc     1020

tgggagccgc acctggggcg ctgatcgagg acatctgcgg ggactgggag aagaagaagc     1080

cggtgcccgt cctcctgggg agtttgctga acagggtgat gttacccaag gccgccctgc     1140

tggtcaccac gcggcccagg gccctgaggg acctccggat cctggcggag gagccgatct     1200

acataagggt ggagggcttc ctggaggagg acaggagggc ctatttcctg agacactttg     1260

gagacgagga ccaagccatg cgtgcctttg agctaatgag gagcaacgcg gccctgttcc     1320

agctgggctc ggcccccgcg gtgtgctgga tcgtgtgcac gactctgaag ctgcagatgg     1380

agaaggggga ggacccggtc cccacctgcc tcacccgcac ggggctgttc ctgcgtttcc     1440

tctgcagccg gttcccgcag ggcgcacagc tgcggggcgc gctgcggacg ctgagcctcc     1500

tggccgcgca gggcctgtgg gcgcagacgt ccgtgcttca ccgagaggat ctggaaaggc     1560

tcggggtgca ggagtccgac ctccgtctgt tcctggacgg agacatcctc cgccaggaca     1620

gagtctccaa aggctgctac tccttcatcc acctcagctt ccagcagttt ctcactgccc     1680

tgttctacac cctggagaag gaggaggaag aggataggga cggccacacc tgggacattg     1740

gggacgtaca gaagctgctt tccggagtag aaagactcag gaaccccgac ctgatccaag     1800

caggctacta ctcctttggc ctcgctaacg agaagagagc caaggagttg gaggccactt     1860

ttggctgccg gatgtcaccg gacatcaaac aggaattgct gcgatgcgac ataagttgta     1920

agggtggaca ttcaacggtg acagacctgc aggagctcct cggctgtctg tacgagtctc     1980

aggaggagga gctggtgaag gaggtgatgg ctcagttcaa agaaatatcc ctgcacttaa     2040

atgcagtaga cgttgtgcca tcttcattct gcgtcaagca ctgtcgaaac ctgcagaaaa     2100

tgtcactgca ggtaataaag gagaatctcc cggagaatgt cactgcgtct gaatcagacg     2160

ccgaggttga gagatcccag gatgatcagc acatgcttcc tttctggacg gacctttgtt     2220

ccatatttgg atcaaataag gatctgatgg gtctagcaat caatgatagc tttctcagtg     2280

cctccctagt aaggatcctg tgtgaacaaa tagcctctga cacctgtcat ctccagagag     2340

tggtgttcaa aaacatttcc ccagctgatg ctcatcggaa cctctgccta gctcttcgag     2400

gtcacaagac tgtaacgtat ctgacccttc aaggcaatga ccaggatgat atgtttcccg     2460

cattgtgtga ggtcttgaga catccagaat gtaacctgcg atatctcggg ttggtgtctt     2520

gttccgctac cactcagcag tgggctgatc tctccttggc ccttgaagtc aaccagtccc     2580

tgacgtgcgt aaacctctcc gacaatgagc ttctggatga gggtgctaag ttgctgtaca     2640

caactttgag acaccccaag tgctttctgc agaggttgtc gttggaaaac tgtcacctta     2700

cagaagccaa ttgcaaggac cttgctgctg tgttggttgt cagccgggag ctgacacacc     2760

tgtgcttggc caagaacccc attgggaata caggggtgaa gtttctgtgt gagggcttga     2820

ggtaccccga gtgtaaactg cagaccttgg tgctttggaa ctgcgacata actagcgatg     2880

gctgctgcga tctcacaaag cttctccaag aaaaatcaag cctgttgtgt ttggatctgg     2940

ggctgaatca cataggagtt aagggaatga agttcctgtg tgaggctttg aggaaaccac     3000

tgtgcaactt gagatgtctg tggttgtggg gatgttccat ccctccgttc agttgtgaag     3060

acctctgctc tgccctcagc tgcaaccaga gcctcgtcac tctggacctg ggtcagaatc     3120

ccttggggtc tagtggagtg aagatgctgt ttgaaacctt gacatgttcc agtggcaccc     3180

tccggacact caggttgaaa atcgatgact ttaatgatga actcaataag ctgctggaag     3240

aaatagaaga aaaaaaccca caactgatta ttgatactga gaaacatcat ccctgggcag     3300

aaaggccttc ttctcatgac ttcatgatct gaatcccccc gagtcattca ttctccatga     3360

agtcatcgat tttccaggtg ttggtgaact gcctgtgact cctctcctcc ccggccccta     3420

cccctcaggg ataatgagtt cattgctggg ctagatgttt tagccatgat tctgcctctg     3480

ttttatacct gcacacatcc ttatctttgt tacatatgaa atatctgtat cacgggtata     3540

ttgagagaaa taaaggtgag agcattcaca aatgaa                               3576


<210> 4387
<211> 643
<212> DNA
<213> Homo sapiens

<400> 4387
agtatcgaga agtacacagg caccactaat aatcagacct gattctggaa accctcttga       60

cactgtgtta aaggttttgg agattttagg taagaagttt cctgttactg agaactcaaa      120

gggttacaag ttgctgccac cttatcttag agttattcaa ggggatggag tagatattaa      180

taccttacaa gagattgtag aaggcatgaa acaaaaaatg tggagtattg aaaatattgc      240

cttcggttct ggtggaggtt tgctacagaa gttaacaaga gatctcttga attgttcctt      300

caagtgtagc tatgttgtaa ctaatggcct tgggattaac gtcttcaagg acccggttgc      360

tgatcccaac aaaaggtcca aaaagggccg attatcttta cataggacgc cagcagggaa      420

ttttgttaca ctggaagaag gaaaaggaga ccttgaggaa tatggtcagg atcttctcca      480

tactgtcttc aagaatggca aggtgacaaa aagctattca tttgatgaaa taagaaaaaa      540

tgcacagctg aatattgaac tggaagcagc acatcattag gctttatgac tgggtgtgtg      600

ttgttgtatg taatacataa tgtttattgt acagatgtgt ggg                        643


<210> 4388
<211> 1735
<212> DNA
<213> Homo sapiens

<400> 4388
cccctttcat aaaagcacag acctaacagc accctgggtg gaaacctctt cagcatttgc       60

ttggaatcag taagctaaaa acaaaatcaa ccgggacccc agcttttcag aactgcaggg      120

aaacagccat catgagtgag gtcaccaaga attccctgga gaaaatcctt ccacagctga      180

aatgccattt cacctggaac ttattcaagg aagacagtgt ctcaagggat ctagaagata      240

gagtgtgtaa ccagattgaa tttttaaaca ctgagttcaa agctacaatg tacaacttgt      300

tggcctacat aaaacaccta gatggtaaca acgaggcagc cctggaatgc ttacggcaag      360

ctgaagagtt aatccagcaa gaacatgctg accaagcaga aatcagaagt ctagtcactt      420

ggtgaaacaa acctgcaaga aattttcaaa tccatacagt attgagtatt ctgaacttga      480

ctgtgaggaa gggtggacac aactgaagtg tggaagaaat gaaagggcga aggtgtgttt      540

tgagaaggct ctggaagaaa agcccaacaa cccagaattc tcctctggac tggcaattgc      600

gatgtaccat ctggataatc acccagagaa acagttctct actgatgttt tgaagcaggc      660

cattgagctg agtcctgata accaatacgt caaggttctc ttgggcctga aactgcagaa      720

gatgaataaa gaagctgaag gagagcagtt tgttgaagaa gccttggaaa agtctccttg      780

ccaaacagat gtcctccgca gtgcagccaa attttacaga agaaaaggtg acctagacaa      840

agctattgaa ctgtttcaac gggtgttgga atccacacca aacaatggct acctctatca      900

ccagattggg tgctgctaca aggcaaaagt aagacaaatg cagaatacag gagaatctga      960

agctagtgga aataaagaga tgattgaagc actaaagcaa tatgctatgg actattcgaa     1020

taaagctctt gagaagggac tgaatcctct gaatgcatac tccgatctcg ctgagttcct     1080

ggagacggaa tgttatcaga caccattcaa taaggaagtc cctgatgctg aaaagcaaca     1140

atcccatcag cgctactgca accttcagaa atataatggg aagtctgaag acactgctgt     1200

gcaacatggt ttagagggtt tgtccataag caaaaaatca actgacaagg aagagatcaa     1260

agaccaacca cagaatgtat ctgaaaatct gcttccacaa aatgcaccaa attattggta     1320

tcttcaagga ttaattcata agcagaatgg agatctgctg caagcagcca aatgttatga     1380

gaaggaactg ggccgcctgc taagggatgc cccttcaggc ataggcagta ttttcctgtc     1440

agcatctgag cttgaggatg gtagtgagga aatgggccag ggcgcagtca gctccagtcc     1500

cagagagctc ctctctaact cagagcaact gaactgagac agaggaggaa aacagagcat     1560

cagaagcctg cagtggtggt tgtgacgggt aggacgatag gaagacaggg ggccccaacc     1620

tgggattgct gagcagggaa gctttgcatg ttgctctaag gtacattttt aaagagttgt     1680

tttttggccg ggcgcagtgg ctcatgcctg taatcccagc actttgggag gccga          1735


<210> 4389
<211> 4344
<212> DNA
<213> Homo sapiens

<400> 4389
ggcggcggcg gcggtgcctg ggcggcagca gcagcagtag cggcagccct gaggacgata       60

tggtgtaaga tacttcttca agattggaca gctggggacc ttcttctgat taaccttaaa      120

ccaacttgta gccatagaga cacctcacaa ggttcccatt tttgttgttg ttgttgttga      180

ttttctgctc acacctttcc tgaccttgca accatgtatg gaagtgcccg ctctgttggg      240

aaggtggagc cgagcagcca gagccctggg cgttcaccca ggcttccacg ttcccctcgc      300

ttgggtcacc gtcgaaccaa cagtacggga gggagttcgg gaagcagtgt tggaggtggc      360

agtgggaaaa ccctttcaat ggaaaatata caatctttaa atgctgccta tgccacctct      420

ggccctatgt atctaagtga ccatgaaaat gtgggttcag aaacacctaa aagcaccatg      480

acacttggcc gttctggggg acgtctgcct tacggtgttc ggatgactgc tatgggtagt      540

agccccaata tagctagcag tggggttgct agtgacacca tagcatttgg agagcatcac      600

ctccctcctg tgagtatggc atccactgta cctcactccc ttcgtcaggc gagagataac      660

acaatcatgg atctgcagac acagctgaag gaagtattaa gagaaaatga tctcttgcgg      720

aaggatgtgg aagtaaagga gagcaaattg agttcttcaa tgaatagcat caagaccttc      780

tggagcccag agctgaagaa ggaacgagcc ctgagaaaag atgaagcttc caaaatcacc      840

atttggaagg aacagtacag agttgtacag gaggaaaacc agcacatgca gatgacaatc      900

caggctctcc aggatgaatt gcggatccag agggacctga atcagctgtt tcagcaggat      960

agtagcagca ggactggcga accttgtgta gcagagctga cagaggagaa ctttcagagg     1020

cttcatgctg agcatgagcg gcaggccaaa gagctgtttc ttcttcgaaa gacattggag     1080

gaaatggagc tgcgtattga gactcaaaag cagaccctaa atgctcggga tgaatccatt     1140

aagaagcttc tggaaatgtt gcagagcaaa ggactttctg ccaaggctac cgaggaagac     1200

catgagagaa caagacgact ggcagaggca gagatgcacg ttcatcacct agaaagcctt     1260

ttggagcaga aggaaaaaga gaacagtatg ttgagagagg agatgcatcg aaggtttgag     1320

aatgctcctg attctgccaa aacaaaagct ctgcaaactg ttattgagat gaaggattca     1380

aaaatttcct ctatggagcg tgggcttcga gacctggaag aggaaattca gatgctgaaa     1440

tcgaatggtg ctttgagtac tgaggaaagg gaagaagaaa tgaagcaaat ggaagtgtat     1500

cggagccatt ctaaatttat gaaaaataag attggccagg tgaaacagga gctgtccaga     1560

aaggacacag aactactcgc cctgcagaca aagctagaaa cactcacaaa ccagttctca     1620

gatagtaaac agcacattga agtgttgaag gagtccttga ctgctaagga gcagagggct     1680

gccatcctgc agactgaggt ggatgctctc cgattgcgtt tggaagagaa ggaaaccatg     1740

ttgaataaaa agacaaaaca aattcaggat atggctgaag agaaggggac acaagctgga     1800

gagatacatg acctcaagga catgttggat gtgaaggagc ggaaggttaa tgttcttcag     1860

aagaagattg aaaatcttca agagcagctt agagacaagg aaaagcagat gagcagcttg     1920

aaagaacggg tcaaatcctt gcaggctgac accaccaaca ctgacactgc cttgacaact     1980

ttggaggagg cccttgcaga gaaagagcgg acaattgaac gcttaaagga gcagagggac     2040

agagatgagc gagagaagca agaggaaatt gataactaca aaaaagatct taaagacttg     2100

aaggaaaaag tcagcctgtt gcaaggcgac ctttcagaga aagaggcttc acttttggat     2160

ctgaaagagc atgcttcttc tctggcatcc tcaggactga aaaaggactc acggcttaag     2220

acactagaga ttgctttgga gcagaagaag gaggagtgtc tgaaaatgga atcacaattg     2280

aaaaaggcac atgaggcagc attggaagcc agagccagtc cagagatgag tgaccgaata     2340

cagcacttgg agagagagat caccaggtac aaagatgaat ctagcaaggc ccaggcagaa     2400

gttgatcgac tcttagaaat cttgaaggag gtggaaaatg agaagaatga caaagataag     2460

aagatagctg agttggaaag gcaagtgaaa gaccagaata agaaggtagc aaatctgaag     2520

cacaaggaac aggtggaaaa aaagaagagt gcacaaatgt tagaggaggc gcgacgacgg     2580

gaggacaatc tcaacgacag ctctcagcag ctacaggaca gtctccgtaa gaaggatgac     2640

aggattgaag agctggaaga agcactaaga gaaagtgtac agataactgc agagcgggaa     2700

atggtgctag cacaagagga atcagccagg accaatgctg aaaaacaggt ggaggagtta     2760

ctgatggcca tggagaaggt aaagcaggaa ctagaatcca tgaaagcaaa gctgtcctcc     2820

acccagcagt ctctggcaga aaaggaaact cacttgacta atcttcgggc agagagaagg     2880

aaacacttag aggaagttct ggagatgaag caagaagctc ttctggctgc cattagtgaa     2940

aaagacgcca atatagctct cttggagctt tcgtcctcta agaagaagac ccaagaggaa     3000

gtggctgccc tgaagcggga gaaggatcgt ctggtacagc agcttaagca gcagacgcaa     3060

aatcgaatga agctaatggc cgacaactac gaggatgacc acttcaaatc ctcccattcc     3120

aatcaaacaa atcacaagcc ctccccagac cagatcatcc agcccctctt agaacttgac     3180

caaaatagaa gtaaattaaa gttgtacatt ggacacctga caaccctctg ccatgaccga     3240

gaccccctga tcctccgtgg actcactcca ccagcttcct ataacttgga cgatgaccag     3300

gcggcttggg agaatgagct gcagaagatg acccgggggc agcttcagga tgagttagag     3360

aaaggtgaac gggacaatgc agaactgcag gagtttgcca acgccattct tcagcagata     3420

gcagaccatt gtcccgacat cctagagcaa gtggtcaacg ccctggaaga gtcctcttga     3480

ccctgcttta tggggaagcc tgaggtagtc aacccaggag ccaagaaaag agaactacga     3540

ggaacaggtg cccggaacct tcttggcacc aaacactaca aacttcatcc caacttgctc     3600

acttgaagaa gtgtgattcc agcaccgttt ctacatctgc catcttactc tgcctttctg     3660

ctttggatgt ggtctctaca ctaaccttct tgatgtccag ggtagataaa gggtcgaatc     3720

tctctgaaga actgccacct ggtcatcagc agtggagaac tgtgggagct ggtggctctg     3780

ccctgacaga gagccatgga gcagaggagc ctctcacctc ctgtcctctg acatgagaat     3840

gaaaccagga atggacttgg agttcaacag gctgagagga tgcctccaat ggaccagaga     3900

gctgagtgtt ctaatatcac aataggtgct ttctcctaaa agggcaaaaa acaatctcaa     3960

aaagattaga aaaagagaag gggggaaggg aagagaaaat cgactcttct ttttactgtc     4020

tcttctgctt actttccaca tgagatgctt tgtaccgggg agctgtgagc aggcctcacg     4080

atggcttggg agcactcgtt ctcccaaggt ctgagtcttc atccagccct gcctgtctgt     4140

cgcagccttc ctcactctgt tcctcggcca gttaacaaga agatggtgtg aggtgttctc     4200

caccagtctc tcctgtttga gactgttgac gttatcatac tgaggtgtta gatcaaatat     4260

ctctaattga agaacatgtg aggttgaaag agcaccagcc agggcaacat agcgtgaccc     4320

tgtctctaca aaaaattaaa aaga                                            4344


<210> 4390
<211> 2130
<212> DNA
<213> Homo sapiens

<400> 4390
agccagggga gaagatttct tacttctgtg acacaattaa aatggatagg tacccactct       60

gaagtgtatt ctgcgacagt agaaaagggg atcaaggaga aacttcaatt aatgaaaaat      120

atgctttcgg aatttttttt ttgacagatc gctttaaata tcatatcgtt aagcagatct      180

tctctggagg agaccagact tttgtacttt gctccaaata cgagaattga tgaacatttt      240

aaaacgagtc ccaaaatccc tgggattgac ctgaactcaa ctagggtgtt atttgagaag      300

ttaatgaact ctcagcactc catgattcta gaacagataa ctggtggtct caggtatgcc      360

cgaaatattt catgaagctg gtaaacctct ataaaggtgc agtcctttat ctactgaggg      420

gaagaaagac attcttaatt cccgtactgt ttaacaatta tatcacagca gctctcaaac      480

tcttggagaa gttatataag gtaaatctta aagtgaagca tgtggaatat gatacatttt      540

acattcctga gatttccaat ctcgtggaca ttcaggaaga ctacctcatg tggttcttgc      600

atcaagcagg gatgaaggct agaccatcaa taatacagga tactgtaaca ctttgttcct      660

accctttcat ctttgatgcc caagccaaga ccaaaatgtt acagacagat gctgaactac      720

agatgcaggt ggcagtcaat ggagccaacc tgcagaatgt cttcatgctt ctcaccctgg      780

agcctctgct ggccagaagc cccttcctgg tccttcacgt tcgcaggaac aaccttgttg      840

gagatgccct aagagagctg agcattcatt ctgatattga tttgaaaaag cctctcaaag      900

taatctttga tggtgaagaa gcagtggatg ccggtggtgt tacaaaggaa ttttttcttt      960

tgctgttaaa agaacttttg aatcccatct atggaatgtt tacctactat caagattcaa     1020

atctcttgtg gttttcagac acgtgttttg tagagcacaa ctggtttcac ttgattggta     1080

taacctgtgg actagctatc tacaactcca ctgtggtcga tctccacttc ccattggctc     1140

tctacaagaa gttactcaat gtaaagcctg gcttggaaga cttaaaggag ttgtcaccca     1200

ctgaaggaag gagtctccaa gagcttttag attaccccgg ggaggatgtg gaggagactt     1260

tctgcctcaa cttcacgatc tgccgagaaa gctatggagt gattgaacag aagaagctga     1320

tacctggggg agataatgta actgtgtgca aggataacag gcaggaattt gtggatgctt     1380

atgtgaatta tgtcttccaa atctcagttc atgaatggta cacagccttc tctagtggct     1440

tcctaaaggt gtgtggtggc aaagtacttg agctcttcca gccttcagaa ctgagggcta     1500

tgatggtggg gaacagcaac tacaactggg aagaactgga agagactgcc atctacaagg     1560

gagattactc ggccacacat cccactgtaa aactattttg ggaaacattt catgagtttc     1620

cattggaaaa gaagaagaag tttctcttgt tcctgacagg cagcgatcgg attcccatct     1680

acggcatggc cagtctgcag attgtcatcc agtccacagc cagcggggag gagtacttgc     1740

cggtggccca cacttgctac aaccttcttg acctccccaa gtacagcagc aaagagattc     1800

tgagtgcccg gctgacccag gcccttgaca actatgaagg gtttagtttg gcctgaggct     1860

tctcagcttg tccagtattt cccttcgttc ctcagtgtcc acattgaggc ctatacagaa     1920

aatcatgggg agtgatttct atttttttat tgtctaagtg ggttgggact tttaaatact     1980

gagcctggtt gatgtgtttc tgggattgta tagcagtaaa caaccttttt gaaaaattag     2040

aggttgggga tggggtgaaa aattggccct tgtatgggag gtgtttttgt ttttgtttta     2100

aaccaaacta cccagtattc cttgcacttg                                      2130


<210> 4391
<211> 2692
<212> DNA
<213> Homo sapiens

<400> 4391
agtggtgtgg taccgggtac ccggagacgt gtatcggacg gtgggccgca gccatggccg       60

agagaaaacc taacggtggc agcggcggcg cctccacttc ctcatcgggc actaacttac      120

ttttctcctc ctcggccacg gagttcagct tcaatgtgcc cttcatccca gtcacccagg      180

cctccgcttc tccggcctcc ctgctcttac cgggaggttc cttcttcagt gcagtcaccg      240

gcacagcagc aggtacctgc cagacctggg gctccctctg ttcaagtgcc atctcctttt      300

ctacttcaaa accaatatga gcctgttcag ccccactggt tttactgcaa ggaggtagaa      360

tacaaacaac tgtggatgcc ttttagtgtg ttcgactctt tgaatcttga agaaatctat      420

aattcagttc agccagatcc ggagagcgtg gttcttggca cggatggagg gcgctacgat      480

gtttacctct atgaccgaat aaggaaggct gcctactggg aagaggagcc agccgaagtg      540

agacgctgta cttggtttta caagggggac acagatagtc gatttattcc ctatactgag      600

gagttcagtg aaaaactaga ggctgaatat aaaaaagctg taaccactaa tcagtggcac      660

cgaagattag agtttccaag tggagagaca attgttatgc acaatccaaa ggttattgtt      720

cagttccagc cctcctcagt gccagatgaa tggggcacca cgcaagatgg acagacaagg      780

cccagggttg taaagcgtgg aattgatgat aaccttgatg aaattcccga cggggagatg      840

cctcaagttg accatttggt gtttgtggtg catggcattg gacctgtgtg tgacttacgc      900

tttaggagca ttattgagtg tgtggatgat tttagggtgg tttctctcaa attgctgcgg      960

acacatttca agaaatcttt agatgacggg aaagtaagca gagtggagtt ccttccagtt     1020

cattggcata gttctttggg tggggacgcc acaggtgtgg acaggaatat taagaaaatc     1080

actttgccaa gtattggtcg atttcgtcac tttaccaatg aaactttgct agatatttta     1140

ttttataaca gccccaccta ctgtcagaca attgtggaaa aagtaggaat ggagataaac     1200

catctgcatg cactctttat gagtcggaac ccagacttca aaggaggtgt ctctgttgct     1260

ggtcacagtt taggttcttt aatattgttt gacatcctgt ctaatcaaaa agatttgaat     1320

ttatcaaagt gccctggacc tcttgctgtt gctaatggag ttgtgaagca gctacatttt     1380

caggaaaagc agatgcctga agagccaaag ctgactttgg atgagtcgta tgaccttgtt     1440

gttgaaaata aagaagtcct aactttgcaa gaaactctgg aagcacttag cctctctgaa     1500

tattttagca cttttgaaaa ggaaaagatt gatatggagt ccctgcttat gtgtacagtt     1560

gatgacctga aggaaatggg gatacccctt ggacccagaa agaagatagc taactttgta     1620

gaacataaag cagccaaact gaaaaaagca gcgtcagaaa agaaggcagt ggcggccact     1680

tctacaaaag gacaagagca aagtgcccag aagactaaag acatggcttc cctcccctca     1740

gaatccaatg agccaaagag gaaacttcca gttggtgctt gcgtgtcttc tgtgtgtgtg     1800

aattatgaat cttttgaagt tggcgccgga caggtttctg ttgcttacaa ctcattagat     1860

tttgaaccag agatattctt tgccttgggg tctccaattg ctatgtttct cactattcga     1920

ggagttgata ggatagatga gaattacagc cttcctacct gtaaagggtt cttcaatatt     1980

tatcatccgc ttgatccagt ggcatataga ttagaaccta tgattgttcc agatttggac     2040

ctaaaagctg ttctcattcc acatcacaaa ggcagaaaaa gacttcattt agaattgaaa     2100

gagagtctct ctcgtatggg atctgatttg aagcagggtt ttattagctc tctcaaaagt     2160

gcttggcaga cattaaatga gtttgcccgt gctcatacgt cttcaaccca gttgcaagaa     2220

gaattggaga aggtggccaa tcagatcaaa gaagaagaag aaaagcaagt agttgaagca     2280

gaaaaggttg ttgaaagtcc agatttttcc aaggatgagg actacttagg aaaggttgga     2340

atgttaaatg gaggccgccg aattgactac gttctccaag aaaaaccaat agagagtttt     2400

aatgaatacc ttttcgctct tcagagtcac ttatgctatt gggaatctga agatactgct     2460

ctgttactac ttaaagaaat ttatcgaaca atgaacatta gtccagaaca gccccagcat     2520

tgatcaaact tcagttttac tgtactttct tgtctgcaca gaaagtccca gtacaacttc     2580

cattgctgag aaaatcctca gaggactttc ccacttcgct cctgtgatgg atgacagaag     2640

agtgattcat taacaattgc tcagccacaa ttctcggata tagggattca aa             2692


<210> 4392
<211> 2127
<212> DNA
<213> Homo sapiens

<400> 4392
aggtacccag tgcagtcctg atctccagct ctccagcggc ttagaacaga cacagaatgg       60

gccgggacca gggacccacc agagacgtct gtagttaata gctggcgctc ttccactaat      120

aaagttttat tgaaataaag catttaaaaa ggcgcccgtc attcttcccc cagcgaccaa      180

tcgaagagta gaatgcctgc gtccctcact ggagcttcag cggtcggaac gcgggggtgg      240

ggcatgtcct gccgaaattt gcgtccttag agcggaagta cggccggaag cccgccatag      300

agtttagtgg ccagagcgac tcttcaggga ggtggcagga aaggcttgga acagctgccg      360

gaggtgacgg agcggcggcc ccgcccggtg cgctggaggt cgaagcttcc aggtagcggc      420

ccgcagagcc tgacccaggc tctggacatc ctgagcccaa gtcccccaca ctcagtgcag      480

tgatgagtgc ggaagtgaag gtgacagggc agaaccagga gcaatttctg ctcctagcca      540

agtcggccaa gggggcagcg ctggccacac tcatccatca ggtgctggag gcccctggtg      600

tctacgtgtt tggagaactg ctggacatgc ccaatgttag agagctggct gagagtgact      660

ttgcctctac cttccggctg ctcacagtgt ttgcttatgg gacatacgct gactacttag      720

ctgaagcccg gaatcttcct ccactaacag aggctcagaa gaataagctt cgacacctct      780

cagttgtcac cctggctgct aaagtaaagt gtatcccata tgcagtgttg ctggaggctc      840

ttgccctgcg taatgtgcgg cagctggaag accttgtgat tgaggctgtg tatgctgacg      900

tgcttcgtgg ctccctggac cagcgcaacc agcggctcga ggttgactac agcatcgggc      960

gggacatcca gcgccaggac ctcagtgcca ttgcccgaac cctgcaggaa tggtgtgtgg     1020

gctgtgaggt cgtgctgtca ggcattgagg agcaggtgag ccgtgccaac caacacaagg     1080

agcagcagct gggcctgaag cagcagattg agagtgaggt tgccaacctt aaaaaaacca     1140

ttaaagttac gacggcagca gcagccgcag ccacatctca ggaccctgag caacacctga     1200

ctgagctgag ggaaccagct cctggcacca accagcgcca gcccagcaag aaagcctcaa     1260

agggcaaggg gctccgaggg agcgccaaga tttggtccaa gtcgaattga aaggactgtc     1320

gtttcctccc tggggatgtg gggtcccagc tgcctgcctg cctcttagga gtcctcagag     1380

agccttctgt gcccctggcc agctgataat cctaggttca tgacccttca cctcccctaa     1440

ccccaaacat agatcacacc ttctctaggg aggaggcaaa tgtaggtcat gtttttgttg     1500

gtactttctg ttttttgtga cttcatgtgt tccattgctc cccgctgcca tgctctctcc     1560

cttgtttcct taagagctca gcatctgtcc ctgttcatta catgtcattg agtaggtggg     1620

tagccctgat gggggtcgct ctgtctggag cataacccac aggcgttttt tctgccaccc     1680

catccctgca tgcctgatcc ccagttccta taccctaccc ctgacctatt gagcagcctc     1740

tgaagagcca tagggccccc acctttactc acaccctgag aattctggga gccagtctgc     1800

catgccagga gtcactggac atgttcatcc tagaatcctg tcacactaca gtcatttctt     1860

ttcctctctc tggcccttgg gtcctgggaa tgctgctgct tcaaccccag agcctaagaa     1920

tggcagccgt ttcttaacat gttgagagat gattctttct tggccctggc catctcggga     1980

agcttgatgg caatcctgga agggtttaat ctccttttgt gagtttggtg gggaagggaa     2040

gggtatatag attgtattaa aaaaaaaaag gtatatatgc atatatctat atataatatg     2100

acgcagaaat aaatctatga gaaatct                                         2127


<210> 4393
<211> 576
<212> DNA
<213> Homo sapiens

<400> 4393
agttccctgc tcctccctct ctgagcacgg agcagaatct gttctgctga agctgctgtt       60

ccacttttta gcttgctata tttgtacagc aacagcagga gcagcccact agctaggccg      120

tgtggccacc ctttggcacc cgcaccggct cagacctgct caggactcag ccagggcaca      180

cagtttgtgt tcttacgtgc atccatctgt ctgtctgtgt gcgtctctgt ggaggactga      240

ggttttcaag tgaaagaggc tgaacataac ttcttttttt caaagttccc tgtgttgtga      300

actgagcttg ggtgaagtga aatctttgag ctcaaagaaa atgaacggca ccctggacca      360

cccagaccaa ccagatcttg atgctatcaa gatgtttgtg ggccaggttc caaggacctg      420

gtctgaaaag gacttgcggg aactcttcga acagtatggt gctgtgtatg aaatcaacgt      480

cctaagggat aggagccaaa acccgcctca gagcaaaggg tgctgttttg ttacatttta      540

cacccgtaaa gctgcattag aagctcagaa tgctct                                576


<210> 4394
<211> 2319
<212> DNA
<213> Homo sapiens

<400> 4394
agaatcagct gtcctctcag actgtgtggg tggtttcccc ggccgcagct ccgtacgggc       60

ttggattgct gggcctcggt gcaccccagc ctcccccact cgggttctga gcttgagctg      120

gcggctcttt aactctgctt cactgttgct cttggcaaca tccacttccg ggagcgagtg      180

ccgtttcccc cgctcaccgc gggctaggga gcgtgggatt ccggactgtg agcggctgtt      240

agtgcgtcgc agctgctggc gatccggcga ccctcggccg gcagtacctc ggcgggaccg      300

ccatggttct gctgcacgtg aagcggggcg acgagagcca gttcctgctg caggcgcctg      360

ggagtaccga gctggaggag ctcacggtgc aggtggcccg ggtctataat gggcggctca      420

aggtgcagcg cctctgctca gaaatggaag aattagccga acatggcata tttctccctc      480

ctaatatgca aggactgacc gatgatcaga ttgaagaatt gaaattgaag gatgaatggg      540

gtgaaaaatg cgtacccagc ggaggtgcag tgtttaaaaa ggatgatatt ggacgaagga      600

atgggcaagc tccaaatgag aagatgaagc aagtgttaaa gaagactata gaagaagcca      660

aagcaataat atctaagaaa caagtggaag ccggtgtctg tgttaccatg gagatggtga      720

aagatgcctt ggaccagctt cgaggcgcgg tgatgattgt ttaccccatg gggttgccac      780

cgtatgatcc catccgcatg gagtttgaaa ataaggaaga cttgtcggga acacaggcag      840

ggctcaacgt cattaaagag gcagaggcgc agctgtggtg ggcagccaag gagctgagaa      900

gaacgaagaa gctttcagac tacgtgggga agaatgaaaa aaccaaaatt atcgccaaga      960

ttcagcaagt aagtactttt tgctttaatg tgtcagtagt ttttgttatt tcccttcaaa     1020

ctgataaaaa tgtacagtga atccgaaaga tttaaactac tggtacaaat attttaatct     1080

tattggctcg ggtttaaact aaaaatatcc tcttcctgca caccaacaaa aactggaaga     1140

aaatatggat tgagtaccaa tatctagagt ttgttttaat atgtggggga gaggaaatat     1200

actatgttaa tttcaagcgt aaaaataggg ctgcaagtaa acagatatgt tccttgaaat     1260

gtaaaatttc gcccgtcact gatttcaggc tttttcaaac tgctgatgct gtgtacagga     1320

gggggaggag gaaaggttcg agacctttga aggacatcgt gtagcgctgt aacctgaggg     1380

gccgccttgg ttttgtgggt gctcctacgt cactaggctg tgattttggg gaaatggggc     1440

cctccacctt atgtagatcc agagtccgtg gctctgagca tcctcccttt cccactggac     1500

ctgcctgcag tgtctgcctt gggaatggtc aagacagaga tggtatcgtg cagcctctgg     1560

tctccacaca gtgagagtcc agggctcagg gctgctcaag accaaggctt cccttgatgc     1620

ttcacttcgg gtgatcagac atgggggacc tgtttatctt tagtagccgg caaaggcaat     1680

cgtaaaacat ttgttgtaac ttcaggattg tcactctaag aacaccttaa tccacaattt     1740

gctctgctct cctctttgca gaggggacag ggagctccag cccgagagcc tattattagc     1800

agtgaggagc agaagcagct gatgctgtac tatcacagaa gacaagagga gctcaaggta     1860

gcaggggaca gatgggcttt ctgcagtgct ggcgcccaca catagcctgt gtgccttacc     1920

tggggctgct ggggagcagt gagctctgca gaatgccggg gaggggtctt tctagagctt     1980

ctgtctgcag gtctgtcggg gtcctgccag gtgtcccctg gtgttagaca tggcagtatc     2040

ctgctcctag agggcaggga gagggggagg tcagtcatgg actctttctt cagtctcttt     2100

atgtgcaaaa cactttcctg aaatgcctgc ctgaataaaa catacttatt tccagagatt     2160

ggaagaaaat gatgatgatg cctatttaaa ctcaccatgg gcggataaca ctgctttgaa     2220

aagacatttt catggagtga aagacataaa gtggagacca agatgaagtt caccagctga     2280

tgacacttcc aaagagatta gctcaccttt ctcctaggc                            2319


<210> 4395
<211> 548
<212> DNA
<213> Homo sapiens

<400> 4395
attgtatgtg aattagccac ccttgtgact atttgaggag agagaagtta gtctaaaata       60

ttatgttaaa ttatgatatt acataatttt attgcataag ttcatcaaac tacttccatc      120

tgaaaaatcc tgatctcaaa atagtttccg ttactatggc aatgacggca gggactacaa      180

caacctttcc tatgagcaac catacccggg aaagagtgac tgtagccaag ctcacattgg      240

agaattttta tagcaaccta attttacagc atgaagagag agaaaccagg cagaagaaat      300

tagaagtggc catggaagaa gaaggattag cagatgaaga gaaaaagtta cgtcgatcac      360

aacacgctcg caaagaaaca gagttcttac ggctcaaaag gaccagactt ggcttggatg      420

actttgagtc tctgaaagtt ataggaagag gagcttttgg agaggtgcgg ttggtccaga      480

agaaagatac aggccatatc tatgcaatga agatattgag aaagtctgat atgcttgaaa      540

aagagcag                                                               548


<210> 4396
<211> 4729
<212> DNA
<213> Homo sapiens

<400> 4396
aagcactttc gcgccgtatc cctccgcccc ccttcccgac accctcgcgg cgagcggttc       60

ttgccgcatc ctgcgcagcc cctgcctact ttggtgcaga ggcgtggggg gcgggacgcg      120

tctttcccgt tcggatcgcg gggaaagcag tggctccaag tgagccagag gagagctgag      180

gagaggaggg ggaggccgac gacctgggcc ctgggcctct gaaggtctgg cgtattctga      240

caggacacag tgagcgtctg tagaggagag gcttgaaata aaggagcacg aatattgcct      300

ggatttctgg aggcctactt taaggctggc caattctgca agaaaggcaa ggaggaggag      360

actggctcac agctctggag gacccccttc tgtcagctgt ggggcttgac accacttgaa      420

caagaaaagg agggggaaac tgcaccacat cagtgaagga ggcagccggt ccagagagac      480

tttctcaaag cccagctgtc ccacctagca ttcaacatca gtcgcactgc atacgtctca      540

tacaattgga agagactcaa agcctcattt cattctctct ccctagatcc acctccagtg      600

gctgctctgc tggtggtgga gttgctgctg acaaccaccc tcaacgggtc tgcacccatc      660

caggaaatat ctgtcttcct ttagcttggt tgtacctgtt ctcactctat ctgtattatt      720

gaattattga ctgagactgt gtttgggaag gaggctgagt gactactgga ctggatattg      780

actctaactc ttattcccaa gcttatatcc ttaatcacct aaagatcaga gtgtgaagaa      840

acaaacctgt gacagatctg tggttgaggt ttagactacg ggaggagtat attacctgac      900

tttctttgta acttgtacca tgactggggc agagattgag cctagtgccc aggccaagcc      960

tgaaaagaag gctggggaag aggttatcgc tgggcctgag agagagaatg atgtccctct     1020

ggtggtcaga cccaaggtta ggacccaggc aactactggg gcaaggccca aaactgagac     1080

caagtctgtg cctgcggcaa ggcccaaaac tgaggcccaa gcaatgtctg gggcaaggcc     1140

caaaactgag gtccaagtaa tgggtggtgc aagacccaaa acggaggctc aaggaatcac     1200

aggggccagg cccaaaaccg atgccagggc agtaggtggc gctcgttcta aaactgatgc     1260

caaggcaatc cctggagcaa ggcccaagga tgaggcccag gcatgggccc agagtgaatt     1320

tgggactgaa gcagtgtcac aggcagaagg agtgtcccag actaatgccg ttgcttggcc     1380

actggccact gctgagtctg gatcagttac taaatctaag ggcctgtcta tggatagaga     1440

actagtcaat gtggatgctg aaacctttcc tggcacccag ggtcagaaag gaatccagcc     1500

ctggtttgga ccaggggagg agactaatat ggggtcttgg tgctattcca ggcccagggc     1560

cagagaggag gcctctaatg agtctgggtt ctggtcagca gatgagacct ctacagcgtc     1620

ttctttctgg actggagaag agacaagtgt cagatcatgg cccagggaag agtccaatac     1680

caggtccagg cacagggcta aacatcagac taatcccagg tccaggccca gatccaagca     1740

agaagcctat gttgattcct ggtctggatc tgaggatgag gccagcaacc cattctcctt     1800

ctgggttgga gaaaatacca ataacttgtt caggcccaga gtcagggagg aggcaaatat     1860

caggtccaag ctcaggacaa atagagaaga ttgttttgaa tctgagtctg aagatgagtt     1920

ctataagcag tcctgggttt tgcctggaga agaggccaat agtagattca ggcacagaga     1980

caaagaagat cctaatactg ccttgaaact cagggcccag aaagatgttg acagtgatag     2040

ggtcaaacaa gaacccaggt ttgaggagga agtcattatt gggtcctggt tctgggcaga     2100

aaaagaggcc agtttggagg gtggagcttc agcaatctgt gaatctgagc caggaactga     2160

ggagggggcc attggcggat ccgcgtactg ggctgaggaa aagtccagtt tgggggctgt     2220

ggccagagaa gaggccaagc cggagtctga agaagaggcc atatttgggt cctggttctg     2280

ggacagagat gaggcctgct ttgacctaaa tccctgtcct gtgtacaagg tcagtgatag     2340

gttcagagat gcagctgagg agcttaatgc atcctccagg ccccaaacct gggacgaggt     2400

cactgttgaa ttcaaacctg gtctttttca tggggttggc ttccgatcca caagcccctt     2460

tggaattccc gaagaggctt ctgaaatgct tgaggcaaag cccaagaacc tggaacttag     2520

cccagaagga gaagagcagg aatctttgct tcagcctgat cagcctagtc ctgagttcac     2580

atttcagtat gatccttcct accggtcagt ccgggaaatt cgagagcatc ttagggccag     2640

ggagagtgca gagtctgaga gttggtcctg cagctgcata caatgtgagc tgaaaattgg     2700

ttctgaagag tttgaagaat tccttttatt aatggacaaa attcgggatc cttttattca     2760

tgaaatatct aaaattgcaa tgggtatgag aagtgcttct caatttaccc gagatttcat     2820

tcgagattca ggtgttgtct cacttattga aaccttgctt aattatccat cctctagagt     2880

taggacaagt tttttggaaa atatgattca catggctcca ccttatccaa atctaaacat     2940

gattgagaca ttcatatgtc aagtgtgtga ggaaaccctt gcacatagtg tggattccct     3000

tgagcagctg actggaataa ggatgcttag acacctcact atgactattg actatcacac     3060

actgattgcc aactatatgt ccgggtttct ctccttatta accacagcca atgcgagaac     3120

gaagtttcac gttctgaaaa tgctattgaa tttgtctgaa aatcctgctg tggcaaaaaa     3180

actattcagt gccaaagctc tttcaatatt tgtgggtctc tttaacatag aagagacaaa     3240

tgataatatt caaattgtta ttaaaatgtt tcagaatatc agtaacatta taaaaagtgg     3300

aaagatgtcc ttaattgatg atgatttcag tcttgagccg cttatttctg catttcgtga     3360

atttgaggag ttagctaagc aactacaagc ccaaatagac aaccaaaatg atcctgaggt     3420

gggacaacaa agttaatatg attaaccacc tgccgctgat cagccttatg ttcccaaaga     3480

gccctgagta gtgctttggt gttcacagtc tgtttttttg ttgtaactta tattttttaa     3540

tgctgatgtt aactttgtca aactcttgtt ttgagctgga tcattttgtg gatgccaaat     3600

gaatatcaaa actgaaaaca catttgttga tatttgtctt gctgtccaga ttgcggtatt     3660

tttcagtatt aagttttcaa tgaactgtgt cacctaagta agctaccctg ctattcgttg     3720

tttaaatata tggttctcta tttgagtctg tgttttcaat aaagttctat gttaaaattg     3780

gcataagtga cccttcttca gtttaagaac catgtacaga taaatcgtgt gcacttacaa     3840

acataggtaa ttattagtat gacaaacatg cgcttattag aaaattctgt tcttgagtta     3900

agaagggaga gattattgtg ggccctgata cttgaggaat gtttccgaga agagggaccc     3960

acttaaattg gtcaggatag aacaaattgg tcaggatagg agagcaagac aacttgcccg     4020

cctgcttgcc caattatgag ccttcccaac aagcaaccta aaattaatac ttcttatagg     4080

acccatttaa attaccatct tagccctggg atttgcctaa gggtaggata agacaaatca     4140

ttaggttgct cttggaagtg ggcagtggtg gtttgaagaa aagtgtgtaa ttgaataatc     4200

tgttctagta gcatggatga acccagtctg cttgaaacaa gtaaaaggag tttgatgaga     4260

aatgcagtta gaaagttggg aagaggccaa tttggggaac agaataagcc aaatctgcat     4320

atttaacaat tcaaagtaca ggtgttactt caatgccacc taaaggctga aagagtagga     4380

tagcacaatt aaatggagtg gggaatatga tttcctttat attcctagac aaaggaaagt     4440

gttaaggaaa taccatgcag ccgttggaat gattatgtat ggataggttt attgacacaa     4500

aaggacatta attattttat atttggtgaa acagagaatg tgacatcatg tatggaaaat     4560

tagattccat ttttaaaaca tctgtaaatg tacacaattc ctatgcaatt tcaatatgaa     4620

tttctaaaca cagtctggaa taaaatatat accttgttaa aaaatgctta gagacaggcg     4680

ttggggagat acaaacatta ataagacaaa ttaaaaaatt aatatgctt                 4729


<210> 4397
<211> 2010
<212> DNA
<213> Homo sapiens

<400> 4397
cgggcgggca ggcgggcagg ccggcaggcg ggtgcgcgga gggctggtgc cccgcagcag       60

gtgggcgggg tgcggttggc ggcggcggct gggccggggg ctgccggctg cgctcgggcc      120

gtgcgcggcg gccgtgcggg cacgccatgg acttcaacat gaagaagctg gcgtcggacg      180

cgggcatctt cttcacccgg gcggtgcagt tcacggagga gaaatttggc caggctgaga      240

agactgagct tgatgcccac tttgaaaacc ttctggcccg ggcagacagc accaagaact      300

ggacagagaa gatcttgagg cagacagagg tgctgctgca gcccaacccc agtgcccgag      360

tggaggagtt cctgtatgag aagctggaca ggaaggtccc ctcaagggtc accaacgggg      420

agctgctggc tcagtacatg gcagacgcgg ccagtgagct ggggccgacc accccctatg      480

ggaagacact gatcaaggtg gcagaagctg aaaagcaact gggagccgcg gagagggatt      540

ttatccacac ggcctccatc agcttcctca cacccttgcg caacttcctg gagggggact      600

ggaagaccat ctcgaaggag aggcggctcc tccaaaaccg gcgtctggac ttggatgcct      660

gcaaagcgag gctgaagaag gccaaggctg cagaagccaa agccacggcc gagggtccca      720

cggtgcctga ctttcaggag actagacctc gtaattacat tctctcggcc agcgcctccg      780

cgctctggaa tgatgaagtg gacaaggccg agcaggagct ccgcgtggcc cagacagagt      840

ttgaccggca agcagaagtg acccgtctct tgctggaggg aatcagtagc actcacgtga      900

accacctgcg ctgcctccac gagttcgtca agtctcagac aacctactac gcacagtgct      960

accgccacat gctggacttg cagaagcagc tgggcagctc ccagggtgcc atatttcccg     1020

gcaccttcgt gggcaccaca gagcccgcct ccccacccct gagcagcacc tcacccacca     1080

ctgctgcggc cactatgcct gtggtgccct ctgtggccag cctggcccct ccgggggagg     1140

cctcgctctg cctggaagag gtggcccccc ctgccagtgg gacccgcaaa gctcgggtgc     1200

tctatgacta cgaggcagcc gacagcagtg agctggccct gctggctgat gagctcatca     1260

ctgtctacag cctgcctggc atggaccctg actggctcat tggcgagaga ggcaacaaga     1320

agggcaaggt ccctgtcacc tacttggaac tgctcagcta ggcaggtgcc cccatccccc     1380

ccgcattctg gcctaggcag gagaggatgg gcgcagccct gccacttaac ttgtttgttg     1440

gtgacacagt tgttcagagt ggggagaatt caccccattc tgtccctgcc cctagtcacc     1500

tagctgtgag ggtgcctgag gctgaatggc tccacccctc ccccagccct gcttctgacc     1560

tgtggctctg gagcccctgc ccctgcctgc atccccgagc accccaccct ccaggctcca     1620

ctaaggaggg aggggctgtc tgcagcagct gcactcagca cctaggccag ggtggggccg     1680

ccgcagatgg gctcaggaag ccccaggtgc actcagcgag agccctgcct ttcagttgcc     1740

aaaagctgca tcaggggaat gcggcaaggc acacagggct ctggcagccc ctggggactg     1800

ggcgctgccc ctgggagggg agagcctggc cagggctggt gttgggcccg gagcagcatc     1860

ttccggtgct atcctcccct cccacccctc acagctcaag ccaagtccag cggccgcagt     1920

cttcacctct ccacactcac tttttatctg gtgtttttac ttctgcctgc gtttgctctc     1980

tagccaataa accgtccttg tgtgcgagtc                                      2010


<210> 4398
<211> 495
<212> DNA
<213> Homo sapiens

<400> 4398
atgacctgct gccagaccag cttctgtgga tatcccagct tctccatcag tgggacctgt       60

ggctccagct gctgccagcc aagctgctgt gagaccagct gctgccagcc acgcagctgc      120

cagactagct tctgcggatt tcccagcttc tcaaccagtg ggacctgcag ctccagttgc      180

tgccagccaa gctgctgtga gaccagctgc tgccagccaa gctgctgcca gatcagctcc      240

tgcggaactg gctgtggcat tggtggtggc atcagctatg gccaggaggg cagcagtgga      300

gctgtgagca cccgtatcag gtggtgccgc ccagacagtc gtgtggaggg cacctaccta      360

cccccctgct gtgtggtgag ctgcacgccc ccatcctgct gccaactgca ccatgcccag      420

gcctcctgct gccgcccgtc ctactgtgga cagtcctgct gccgcccagt ctgctgctgt      480

gagcccactt gctga                                                       495


<210> 4399
<211> 1889
<212> DNA
<213> Homo sapiens

<400> 4399
gtaacgttcg ggctccgtct caggggctga agtttgtgag gtgtagtatt gagtcctgtt       60

tgagctattg ttctcttttt cctgaaaaat ggcactgtca aagagggagc tggatgagct      120

gaaaccatgg atagagaaga cagtgaagag ggtcctgggt ttctcagagc ctacggtggt      180

cacagcagca ttgaactgtg tggggaaggg catggacaag aagaaggcag ccgatcatct      240

gaaacctttt cttgatgatt ctactctccg atttgtggac aaactgtttg aggctgtgga      300

ggaaggccga agctctaggc attccaagtc tagcagtgac aggagcagaa aacgagagct      360

aaaggagttc caggaagcgc tcgcccctgg ccgaggatat gtccttgcaa aacacgagcc      420

ctcctagtga agaggggatg tcacccaaag cctaccaccg gaggtgtttg gtgatgactc      480

tgagatctct aaagaatcat caggagtaaa gaagcgacga ataccccgtt ttgaggaggt      540

ggaagaagag ccagaggtga tccctgggcc tccatcagag agccctggca tgctgactaa      600

gctccagatc aaacagatga tggaggcagc aacacgacaa atcgaggaga ggaaaaaaca      660

gctgagcttc attagccccc ctacacctca gccaaagact ccttcttcct cccaaccaga      720

acgacttcct attggcaaca ctattcagcc ctcccaggct gccactttca tgaatgatgc      780

cattgagaag gcaaggaaag cagctgaact gcaagctcga atccaagccc agctggcact      840

gaagccagga ctcatcggca atgccaacat ggtgggcctg gctaatctcc atgccatggg      900

cattgctccc ccgaaggtgg agttaaaaga ccaaacgaaa cctacaccac tgatcctgga      960

tgagcaaggg cgcactgtag atgcaacagg caaggagatt gagctgacac accgcatgcc     1020

tactctgaaa gccaatattc gtgctgtgaa gagggaacaa ttcaagcaac aactaaagga     1080

aaagccatca gaagacatgg aatccaatac cttttttgac ccccgagtct ccattgcccc     1140

ttcccagcgc cagagacgca cttttaaatt ccatgacaag ggcaaatttg agaagattgc     1200

tcagcgatta cggacaaagg ctcaactgga gaagctacag gcagagattt cacaagcagc     1260

tcgaaaaaca ggcatccata cttcgactag gcttgccctc attgctccta agaaggagct     1320

aaaggaagga gatattcctg aaattgagtg gtgggactct tacataatcc ccaatggctt     1380

tgatctagga aaatcccaag agagaagatt attttggaat cacaaatctt gttgaacatc     1440

cagcccagct caatcctcca gttgacaatg acacaccagt tactctggga gtatatctta     1500

ccaagaagga acagaaaaaa cttcggagac aaacaaggag ggaagcacag aaggaactac     1560

aagaaaaagt caggctgggc ctgatgcctc ctccagaacc caaagtgaga atttctaatt     1620

tgatgcgagt attaggaaca gaagctgttc aagaccccac gaaggtagaa gcccacgtca     1680

gagctcagat ggcaaaaaga cagaaagcgc atgaagaggc caacgctgcc cgaaaactca     1740

cagcagaaca gagaaaggtc aagaaaatta aaaagcttaa agaagacatt tcacaggggg     1800

tacacatatc tgtatataga gttcgaaatt tgagcaaccc agccaagaag ttcaagattg     1860

aagccaatgc tgggcaactg tacctgaca                                       1889


<210> 4400
<211> 1146
<212> DNA
<213> Homo sapiens

<400> 4400
aaatttcccg ggccgggagc gctgggcctg ccgggaaggc gctgggacgg ttacccagcg       60

ggccgccggc ggtcgtgggc aagcttcgcc atgcagagca ctgacctagg caacaaggag      120

agcggcaaga tatggcaccg caagccgtcc ccggccacgc gggacggaat tatagtgaac      180

attattcaca acacttccga ttaccatcca aaagttttgc gatttttgaa tgtggctttt      240

gatggcacag gcgactgctt aattgctggg gaccaccaag gaaatattta tgtttttgac      300

ttacatggaa acaggttcaa tcttgttcag cgaacagcac aagcttgcac agctctggcc      360

tttaatcttc gtaggaaatc tgaattcctt gtggcattag ctgattattc tattaaatgt      420

tttgatacag tcaccaagga gctagttagc tggatgagag gacatgaatc atcagtattt      480

tcgatctctg tgcatgcatc agggaaatat gccatcacaa cttcttctga tacagcacaa      540

ttatgggact tggatacctt tcagagaaaa agaaagctga atattcgcca gtctgtgggt      600

atacagaagg ttttctttct accattaagt aataccatcc tcagctgttt taaagataat      660

tccatttttg cctgggaatg tgacacactt ttttgcaaat atcaattgcc agctccacct      720

gaaagctcta gtatattata caaagtgttt gctgtaacca gagatggccg aatcctggct      780

gctggaggca agtcaaatca tcttcatttg tggtgcttgg aagctaggca gctctttaga      840

attatccaga tgcccactaa agttcgagcc attcgccatc tggaatttct tcctgatagt      900

tttgatgctg gttctaatca ggttcttgga gtactaagtc aagatggtat tatgagattt      960

atcaatatgc agacttgtaa acttctcttt gagattggga gcctcgatga aggaattagc     1020

tcatcagcaa ttagcccaca tggacggtac attgcatcta ttatggaaaa tggaagtcta     1080

aacatatatt cagttcaggc tttaacacaa gaaataaata aggaagaagt tcgtgctcaa     1140

aattaa                                                                1146


<210> 4401
<211> 1616
<212> DNA
<213> Homo sapiens

<400> 4401
agcgaggact tctaccgctg cggctactgc aagaacgagt cgggcagccg ctccaatggc       60

atgtgggcac attccatgac agtacaggat tatcaggatc tcatagaccg aggatggcga      120

agaagtggaa aatatgtgta caaacctgtc atgaatcaaa catgttgtcc tcagtacaca      180

ataagatgag cccatggatt ccacaatgga tgatgctgtt gcgggtgact ttgcattgat      240

aaataaactg gatatacagt gtgatcttaa aacactcagt gatgacatca aagagagttt      300

agagagtgaa ggaaaaaatt caaagaaaga agaacctcag gaattacttc agtcacaaga      360

tttcgtagga gagaagttgg gctctggtga accgtcacat tcagttaaag ttcacacagt      420

tcctaagcca ggcaaagggg ctgatttgag taagcctcca tgtcgaaaag caaaggaaat      480

ccggaaagaa aggaaaaggt taaaactaat gcagcagaac ccagctggag aacttgaggg      540

tttccaggct caaggtcacc caccatcttt gtttccacca aaggctaaat ccaaccagcc      600

aaaatcactc gaagatttaa tttttgagtc tttaccagag aatgcatcac acaagttaga      660

ggtgagggtg gtgagatcat ctccaccaag ttcgcagttc aaagccacac ttctggagtc      720

ttaccaggtc tataaacgtt accagatggt tattcacaag aacccacctg atacgccaac      780

cgaaagccag ttcacaagat tcctttgcag ttcacccttg gaggcagaga ctccccctaa      840

tgggccagat tgtggctatg gctcctttca ccagcagtac tggcttgacg gaaagatcat      900

tgctgtgggg gtgattgaca tcctcccaaa ctgtgtatca tctgtgtatt tgtactacga      960

tcctgattat tcgtttttgt ctttgggcgt ctactctgca ctacgagaaa ttgcttttac     1020

taggcagctt catgagaaaa cttctcaact cagctattat tatatgggtt tctacattca     1080

ttcatgtccc aagatgaaat ataagggtca gtatagacct tctgatttgc tgtgccctga     1140

gacatatgtt tgggtaccca ttgagcaatg cctgccttca cttgaaaact ccaagtactg     1200

ccgtttcaac caggacccag aagcagtgga tgaggatcgc agtacggaac ctgaccgatt     1260

gcaggtgttt cacaagagag ccatcatgcc ttacggtgtt tataagaaac agcagaaaga     1320

cccaagtgag gaggctgctg ttctgcagta cgccagcctg gtggggcaga agtgctccga     1380

gcggatgctg ctgttcagaa actgacctgt tcacctctgc cgggaagttc ctgtgttgtg     1440

ctgatgattt gtgccaggat acatattcag tacctgtggg gaaataactg tcaccaccca     1500

caaattagac attttttatt ttgactatct atggctttta aaaaatattt tgtggcaatg     1560

tatctgtgag aatctcatag ttaatataaa gattttaaaa ctgcattatg acctag         1616


<210> 4402
<211> 1047
<212> DNA
<213> Homo sapiens

<400> 4402
ggcccggcgc gccgcggccg cgcgaggccc ccgccgtcgc cgacgcccga gcgccggagc       60

cccggccccg ccccgcgagc gccgagactt gttggccgcg gagactgcga ccctcttctc      120

tcagtctgcc ttactaccat gccgctctac gagggcctgg ggagcggcgg ggagaagacg      180

gcggtcgtga tcgacctggg agaggccttt accaagtgtg gatttgctgg agaaactggt      240

ccaagatgta taattcctag tgtgataaaa agagctggga tgcctaagcc tgtcagagtt      300

gttcagtata atatcaatac agaagaatta tattcctacc taaaggaatt catccacata      360

ctatatttca ggcatctatt ggtgaatccc agagaccgcc gagttgtgat tatcgaatcg      420

gtattatgtc cttctcactt cagagagaca ctcactcgtg ttcttttcaa atattttgag      480

gttccatctg tcttgcttgc tccaagtcat ctaatggctc ttctgacgct tggaattaat      540

tctgccatgg tcctagattg tggatatagg gaaagcctgg tgttacccat atatgaagga      600

atcccagttc taaattgttg gggagcacta cccctaggag gaaaagctct tcacaaagag      660

ttggaaactc aactattgga acaatgtact gttgacacaa gtgttgctaa agaacagagc      720

cttccctcag tgatgggttc agttccggaa ggtgtcttag aggacattaa agcgcgtact      780

tgctttgtaa gtgatctgaa gcgaggacta aaaatccaag cagcaaaatt taatattgat      840

gggaataatg agcgtccctc cccaccccca aatgttgact atccattaga tggagagaag      900

attttacata tccttggatc aatcagagat tcagttgtgg aaattctttt tgaacaagat      960

aatgaagagc aatcagttgc cactttaata ttggattccc ttatacagtg ttgctcttgt     1020

tgcccaggct ggagtgcaat ggcatga                                         1047


<210> 4403
<211> 563
<212> DNA
<213> Homo sapiens

<400> 4403
aacgcacact taaggctcca gcaaagtaag tgccaaaaag gggagaatgg gaagaatatg       60

ctgtatttca caaaaagcat ctaagtagcc atctggaaaa gccagaatga acttcaatgg      120

tgcatccagg tggctccgct gccggatggg agtgccccag tgtgctggat gaagctggcg      180

catgcaccat gtcatcatgt gtctctagcc agcccagcag caaccgggcc gccccccagg      240

atgagctggg gggcaggggc agcagcagca gcgaaagcca gaagccctgt gaggccctgc      300

ggggcctctc atccttgagc atccacctgg gcatggagtc cttcattgtg gtcaccgagt      360

gtgagccggg ctgtgctgtg gacctcggct tggcgcggga ccggcccctg gaggccgatg      420

gccaagaggt cccccttgac acctccgggt cccaggcccg gccccacctc tccggtcgca      480

agctgtctct gcaagagcgg tcccagggtg ggctggcagc cggtggcagc ctggacatga      540

acggacgctg catctgcccg tcc                                              563


<210> 4404
<211> 1362
<212> DNA
<213> Homo sapiens

<400> 4404
ttcttctctt ccccggcagc acagtgtggc tgtttgtctc cttgcccgcc aaagttctgc       60

ccagtccaac gactccacgc agctcgccct tggttatttg gacaagaggc acattgaccc      120

aatttggaga cgtattttgg aaggaggcga acagttgtct ccaaacgtgg tgttgccgtc      180

agtggtccca ccaagaggag gggaatggca gattcactgg agtcaacccc cttgccttcc      240

cccgaagatc gtctggccaa actccatcct tctaaggagc tcctggaata ttatcaaaag      300

aagatggctg agtgtgaggc agaaaatgag gacttgctga agaaactgga actctacaaa      360

gaagcttgtg aaggacagca taaacttgaa tgtgatttgc agcagaggga ggaagagatt      420

gctgaattgc agaaagctct aagtgatatg caggtctgcc tcttccagga acgggaacat      480

gttttacgcc tctactcaga aaatgaccga ctgagaatca gggagctaga agacaagaaa      540

aagattcaga atctcttggc tcttgtggga acagatgctg gagaagtgac ctatttttgt      600

aaggagcctc ctcacaaagt caccattctc caaaagacta tccaggctgt aggtgaatgt      660

gagcagagtg aatcttcagc tttcaaagca gatcctaaaa taagcaaaag aagaccatcg      720

agagagagaa aagaaagttc tgagcattac caaagagaca tacagacact catcctacag      780

gtggaagcac tgcaggctca gctgggagag cagaccaaac tttctcgaga acaaattgaa      840

gggctcatcg aggacagacg gattcacctt gaggaaatac aagttcagca ccagagaaat      900

cagaacaaaa tcaaagagct aaccaaaaat cttcaccaca cccaagaact gctctatgag      960

agcaccaaag attttctgca actcagatct gaaaaccaaa ataaagagaa gtcatggatg     1020

cttgaaaaag ataatttgat gtcaaagatt aagcaatata gggtgcagtg taagaagaaa     1080

gaagataaaa ttggaaaagt gttgcccgtt atgcatgaga gtcaccatgc tcaaagtgaa     1140

tatattaagt ccctaaaaga taagttagta caagagaaaa agctgtccaa tatgtaccaa     1200

gagcagtgca tttccttaga agaagaactt gcccgaattc gtgaggaaga gggaatgagg     1260

agagagatct tcaaggatcg cactaacaag atggggaagc gtttacagat aatgacaaaa     1320

cgctatgagg cattggagcg tcgacgtatc ctggaagtag aa                        1362


<210> 4405
<211> 1976
<212> DNA
<213> Homo sapiens

<400> 4405
agtcacctgt gctgagccat catggagagt gagggcctgt aagggtggac acagtatgca       60

ggagggacaa atcttcctca ccggacaggt ggggatccct gcggtgcact aggggaatgc      120

acacaggggg cactatgacc tggcggccca cggggcacgg ggacgcacca ggtagccttg      180

ggatctgcaa gtccctcccg gaccctgggg agtgccatga cggcttccag cagcagtcac      240

tgtcctgggc gcgtcccgcg ctctagccca ggtgggtccc acaacggtgt gaccaaggac      300

gtcctatgac caccccttga cagcactctc gagtggaccc tgaggagctc ttcaccaagc      360

tcgaccgcat tggcaagggc tcgtttgggg aggtctacaa gggcatcgat aaccacacaa      420

aggaggtggt ggccatcaag atcatcgacc tggaggaggc cgaggatgag atcgaggaca      480

tccagcagga gatcactgtc ctcagtcagt gcgacagccc ctacatcacc cgctactttg      540

gctcctacct aaagagcacc aagctatgga tcatcatgga gtacctgggc ggcggctcag      600

cactggactt gcttaaacca ggtcccctgg aggagacata cattgccacg atcctgcggg      660

agattctgaa gggcctggat tatctgcact ccgaacgcaa gatccaccga gacatcaaag      720

ctgccaacgt gctactctcg gagcagggtg acgtgaagct ggcggacttt ggggtagcag      780

ggcagctcac agacacgcag attaagagga acacattcgt gggcaccccc ttctggatgg      840

cacctgaggt catcaagcag tcggcctacg acttcaaggc tgacatctgg tccctgggga      900

tcacagccat cgagctggcc aagggggagc ctccaaactc tgacctccac cccatgcgcg      960

tcctgttcct gattcccaag aacagcccac ccacactgga gggccagcac agcaagccct     1020

tcaaggagtt cgtggaggcc tgcctcaaca aagacccccg attccggccc acggccaagg     1080

agctcctgaa gcacaagttc atcacacgct acaccaagaa gacctccttc ctcacggagc     1140

tcatcgaccg ctataagcgc tggaagtcag aggggcatgg cgaggagtcc agctctgagg     1200

actctgacat tgatggcgag gcggaggacg gggagcaggg ccccatctgg acgttccccc     1260

ctaccatccg gccgagtcca cacagcaagc ttcacaaggg gacggccctg cacagttcac     1320

agaagcctgc ggagcccgtc aagaggcagc cgaggtccca gtgcctgtcc acgctggtcc     1380

ggcccgtctt cggagagctc aaagagaagc acaagcagag cggcgggagc gtgggtgcgc     1440

tggaggagct ggagaacgcc ttcagcctgg ccgaggagtc ctgccccggc atctcagaca     1500

agctgatggt gcacctggtg gagcgagtgc agaggttttc acacaacaga aaccacctga     1560

catccacccg ctgaagcgca ctgctgttca gataggggac ggaaggtcgt ttgtttttgt     1620

tctgagctcc ataagaactg tgctgacttg gaaggtgccc tgtgctatgt cgtgcctgca     1680

gggacacgtc ggatcccgtg ggcctcacat gccaggtcac caggtcaccg tctccttcca     1740

cccctgcagt gtgctgttgt gcacgtcagg gacgctgttc tctatgccca ctgccctcct     1800

ccctctcctg gcccagcagt attgctcacg ggggctccag ccgccggcgt ggccctcatg     1860

agctacgcct gggtcttctg cagactcatg cagccctatg gccgctcaga ccaaggcgca     1920

gagcaactat cagggcagct ctgcctcctc ctcccatgag gtggggagag gcaaca         1976


<210> 4406
<211> 1918
<212> DNA
<213> Homo sapiens

<400> 4406
gcaacaagtt aagctgaaga ccgaagcaag agctggttca ggtggcagcc acagcagcct       60

caggtggcct ctcagagtct gagactgggc ccatggagga agtggagcgg caggtcctcc      120

cagaccccga ggtgctggaa gctgtggggg acaggcagga tgggctaagg gaacagctgc      180

aggccccagt gcctcctgac agtgtcccca gcctgcaaaa catgggtctt ctgctggaca      240

agctggccaa ggagaaccag gacatccggc tgctgcaggc ccagctgcag gcccaaaagg      300

aagagcttca gagcctgatg caccagccca aagggctaga ggaggagaat gcccagctcc      360

ggggggctct gcagcagggc gaagccttcc agcgggctct ggagtcagag ctgcagcagc      420

tgcgggcccg gctccagggg ctggaggccg actgtgtccg gggcccagat ggggtgtgcc      480

tcagtggggg tagaggccca cagggtgaca aggccatcag ggagcaaggc cccagggagc      540

aggagccaga actcagcttc ctgaagcaga aggaacagct ggaggctgag gcacaggcat      600

taaggcaaga gttagagagg cagcgacggc tgctggggtc tgtacagcag gatctggaga      660

ggagcttgca ggatgccagc cgcggggacc cagctcatgc tggcttggct gagctgggcc      720

acagattggc ccagaaactg cagggcctgg agaactgggg ccaggaccct ggggtctctg      780

ccaatgcctc aaaggcctgg caccagaagt cccacttcca gaattctagg gagtggagtg      840

gaaaggaaaa gtggtgggat gggcagagag accggaaggc tgagcactgg aaacataaga      900

aggaagaatc tggccgggaa aggaagaaga actggggagg tcaggaggac agggagccag      960

caggaaggtg gaaggagggc aggccaaggg tggaggagtc ggggagcaag aaggagggca     1020

agcgacaggg cccgaaggaa cccccaagga aaagtggtag cttccactcc tctggagaaa     1080

agcagaagca acctcggtgg agggaaggga ctaaggacag ccatgacccc ctgccatcct     1140

gggcagagct gttgaggccc aagtaccggg caccccaggg ctgctcaggt gtggacgagt     1200

gtgcccggca ggagggcctg actttctttg gcacagagct agccccagtg cggcaacagg     1260

agctggcctc tctgctaaga acatacttgg cacggctgcc ctgggctggg cagctgacca     1320

aggagctacc cctctcacct gctttctttg gtgaggatgg catcttccgt catgaccgcc     1380

tccgcttccg ggattttgtg gatgccctgg aggacagctt ggaggaggtg gctgtgcaac     1440

agacaggtga tgatgatgaa gtagatgact ttgaggactt catcttcagc cacttctttg     1500

gagacaaagc actgaagaag aggtcaggga agaaggacaa gcactcacag agcccaagag     1560

ctgcggggcc cagggagggg cacagccata gccaccacca ccaccaccgg ggctgacacc     1620

ctgccccaca gggaatggcc ttggcctggc ccagcccaag atcccagcgt tatctaactc     1680

ctggagggtg gactctgtcc tggcttgttt ggtgtcctca gatatctttc acacagtaga     1740

gcaaaatcac cagccctgca ctgatgtcac tttatgtaga aaaaggcctt agctggacct     1800

gcgttgccgt ctatgcaaat gcatgcaaat actccaggcc ctgggatgtg ggcttgtgtt     1860

ttgtcactgt gaagggggag atgggagagg agcctgtttt ggggtggggt ctggggaa       1918


<210> 4407
<211> 5437
<212> DNA
<213> Homo sapiens

<400> 4407
attatcttct ggcctctgga gaaagataga gtagctcgct gattggatcc tgaggttgaa       60

ataactccac atctcactgc gctccgacta gagcaacgag aagagtgtct ggaatggttg      120

ggagacattt taagcaggac aaatccagcc ttaggctaga ctgcacctgt ccacagccca      180

gcccaggccc atggaaaaga atagtaaaac ctttgtcttt aagcacatag aatatgtgtg      240

aaacccagaa ggctagaaaa gaaagggaag tggaggagaa aaggcactgg gactccagct      300

gggagtatga agactacggg agtgtacgga aaaggaacct tacagtgctg gatggactct      360

acagagaaaa tgacttggat cccaggtact gggccaaggg acagcatcag ccctacagaa      420

aaagggattg tggatactgg gattttgaac agagtgaacc aagctatatg gactgtgggg      480

aagcacatga aagtggaaag ggctgtgtgt accacggagg tcatgatggt tataggagtc      540

cagaaaatgt agattatgag agtctcagcc ctgggacgaa ggataattca cctacgagaa      600

gcccagatgt gacctcgaaa gctggtggat acggggaggc aaatggctac tcagactgta      660

agaatctgaa ttataatcct gaggactcta aaaaagctga acagttgact gactgtaggg      720

gtttggatga ttcttcagcg aatttaggtc aacctcagtt gtggtatata gaccatgaga      780

atgttaacca taatcttgag gattgttggg caactaattt ttattgtaga gaacacagca      840

atttatatca tgttcctggg agttatcctg atggtcagcc tgtgagcttt tcagattcga      900

atggtgtcaa tgaagataag gaatttatca aataccatga aggggacagg aatgttcatc      960

aaaatgacaa catgtatccc aaagcaaaga ctcatattat ggatcagggt gattttgata     1020

cagaaaataa aggctatgat gctttatttg caaactgtgc atataaatct cgtaattcca     1080

gagggacaga ttctctccat caaatggaga atttggagta taatggcact gacataccaa     1140

gaacaaaggc acatgggggc agcaggatcc ttctggatgg tctgcagact cagtgtacca     1200

ggggagaaca aggaggacat catttgggga ttcctcagag ctcgtcatta gagaagaaca     1260

tctggcattt agaggaagag aaaaaattaa atggcccaga gacttggaga aggaatagtt     1320

gcctccgccg cacagcaccc agcaccctga ggcgctcaga gttcgtgcaa aacagcaaga     1380

aaacccaaga aatgacgctc ctctcctccc agtcttcatc actggtggcc ccttctgggt     1440

ctgtgtctgc cgaaaatcca gagcagagga tgctggagaa gagagccaag gtcatagaag     1500

aacttcttca gacagaaaga gactacattc gggatctgga aatgtgtatt gagcggatca     1560

tggtacccat gcagcaggca caggtaccaa acattgattt tgagggactt tttggaaata     1620

tgcagatggt gattaaggtc tcgaagcaat tattggctgc tctggaaatc agcgatgctg     1680

taggacctgt gtttcttggt caccgggatg agcttgaggg aacatacaag atttactgcc     1740

agaatcatga tgaggccatt gcgctgcttg aaatctacga gaaggatgag aagatccaga     1800

agcatcttca ggactccttg gcagatctga agagcctata caacgaatgg ggatgcacaa     1860

attatattaa cctgggctcc ttcctcatca aaccagtaca gagagtaatg cgttacccgc     1920

tgttgctaat ggagttgctg aattccaccc cagaatccca cccagataaa gtgcctttaa     1980

ccaatgcagt ccttgcggtc aaggaaatca acgttaacat taatgaatat aaacggcgaa     2040

aggacctggt cctcaagtac cgtaagggtg atgaagatag ccttatggag aaaatttcca     2100

aactgaacat ccactccatc atcaagaaat ccaaccgagt tagcagtcac ctgaagcatc     2160

tcactggctt tgctcctcag ataaaagatg aagtatttga agaaacagaa aaaaacttcc     2220

gaatgcaaga aagattgatt aagtctttta tccgagacct gtctctctac ctccagcaca     2280

tccgggagtc cgcatgtgtg aaagtggtgg ctgctgtgag catgtgggat gtgtgcatgg     2340

agagaggaca ccgggacctg gagcagtttg agagggtgca tcgctacatc agtgaccagc     2400

tcttcacaaa ctttaaggag aggacagagc ggcttgtcat ctccccctta aatcagttac     2460

tgagcatgtt tacagggccc cataagctgg tacagaaacg ctttgacaag ctcctggact     2520

tctataactg tacagaacgg gcagaaaagc taaaggacaa gaagaccctg gaggagctgc     2580

agtcggcccg gaacaactat gaggccctga atgcacagct gctggatgag ctgcccaagt     2640

tccaccagta cgcccagggc ctcttcacca actgtgtcca cggctatgct gaagcccact     2700

gtgactttgt gcaccaggct ctggagcaat taaagccact gctttcgtta ctcaaagtgg     2760

ctggcagaga gggaaacctt attgccatct tccacgaaga gcacagcaga gttctgcagc     2820

aactccaggt ttttaccttc ttcccggagt ctcttccagc taccaagaag ccatttgaga     2880

ggaaaaccat tgaccgccag tctgctcgaa agccactcct gggcctgcca agttacatgc     2940

tacagtcaga agaactccgg gcctccctcc tggccaggta tccccctgaa aaactcttcc     3000

aggcagaacg gaacttcaat gctgctcaag acttggatgt ctcacttttg gaaggtgacc     3060

tggtgggtgt gattaagaaa aaagacccca tgggcagcca gaaccgctgg ctgattgaca     3120

atggagtcac caaaggcttc gtgtacagct ctttcctaaa gccctacaat cctcgccgca     3180

gccactccga tgcctccgtg ggtagccact cctccacaga gtctgagcac ggcagctcct     3240

cccccaggtt cccacgccag aacagcggca gcaccctgac cttcaacccc agcagcatgg     3300

ctgtatcctt tacctcgggg tcttgccaga agcagcctca agatgcatct cctccgccaa     3360

aagaatgtga ccaaggaact ctcagtgcat ccctaaatcc gagtaattca gagagtagtc     3420

cttccagatg cccttcagac ccagactcca cctcccagcc aaggtcaggg gactctgcag     3480

atgtagctag agatgtaaag caacccactg ccacgccgag gagctaccgg aacttcaggc     3540

atccagaaat agttggctac tccgtaccag gacgaaatgg gcaaagtcaa gacctcgtca     3600

aaggatgtgc aagaacagcc caggctccgg aagacagaag tacagagcca gatggcagtg     3660

aggcagaagg caaccaggtc tattttgctg tctacacctt caaggcacga aacccaaatg     3720

agctgagcgt gtcagccaat cagaaactca agatcctcga gtttaaagat gttacaggaa     3780

atacagagtg gtggttagct gaggttaacg ggaagaaggg ctacgttccc tccaattata     3840

tccgcaaaac cgagtacacc tgagcccacg ttgcctgcca cccagccttg ctgcctttgc     3900

tttcagtccg ccgagggttc tggcggccca ccgagagggc gcctgctcct gagacacagg     3960

ccctgtctgc gttgcttaac catggcatgg tggagcacac cacagatctt gttctcctcg     4020

attgggttgt aaaccttgat gctcactaga atctctagaa tttgaaatgg accctggggc     4080

tttgcaaatg acttagtgac tatgagaaga gagacaagtc ttagagctgg cttttggaaa     4140

ggagaaactt gcagtcagaa gcccagtgtc ctatgtatgc aggaagctgt gctctagcaa     4200

tagacagtgt tggtaatggt tgtgctgtac ggcgtttggg gtggccccat gttccatgct     4260

cagctgaccg gatgccaact cagatgaaaa gaattcatgg ctctgggcac cccgtgaggc     4320

agtgcttgca catggctggg agtttgtcgg gattgaacca aacctagtgc ttcaaagctc     4380

ctgggacacc tccagtgtcc agcacacatt ctcatacata ctgcccctaa tttctaaagt     4440

ccctaaagca ctacattctg taaccttgtt tcttttactc cattcccaga ttagttatgc     4500

aaaattcaac tgcgttctac ttttagaagt gtttagggtc tttattttct gttgaccctt     4560

catctgaaag attctcttcc cttgttaggt acaatcactg cccccccgct tttttttttg     4620

agatggggtc ttgctatgtt gcccaggctg gtcttaaacg cctgggctca agcaaccctc     4680

ccgcctccct gctgagatta caggtgtaag ccaccatacc gcaacctcaa tgacaccttt     4740

ctgatggtct ttacacagtc tgtgatgtct ggtggccccc ctgccctgga ctcaataatt     4800

gatagatttt cctagagtaa cagtatgaga gctccagcca ttccattaaa agtattagtt     4860

ctgctttgag ctgaaaccag ttgagcctaa tggaagactg gatgtctttc ttcttcatcc     4920

aagcacccta atgactgttt agttacatcc atagatgcag acaacataac acctgtgact     4980

tacttgaatt gggataagcc attccagaag tagcttatcc tagacttgga aataagattt     5040

ttttcaccac taacttccat gcttcagaga tgacattcaa agccagattc ccaagtgcct     5100

gatcatacct cccagtctca ggaagatatt tgcttacccc ttagaccaag aatcttaaga     5160

tcttccccag ctatgaagcc tatcttggaa tgggaaacca tgaaatttgt cttttaaaag     5220

aaagggaaga aatagcctta cagcccctgt tcctccaagt gcacatttag ccttaaaatc     5280

ctgggagtcg ggagacaccg tggagtccta acatccacag tgtctgctgg tcgtggtcag     5340

aaggcagtaa tgcaagagtc cttttgtgaa gagtgtttct atgtagagat gtttatattt     5400

aagtagttct tttataaata aaagcatttc taatggc                              5437


<210> 4408
<211> 636
<212> DNA
<213> Homo sapiens

<400> 4408
agacaagttt agagcaagtc ctgattgtat aacaatcctg tgcaaaccga acggtcaagc       60

cattgcgtgg tacaccccta tccactggaa gcaagcgtgg gaaaaattag atgctgacgt      120

tgaatttaac agatgttcag tagtatctcc aacattccga aagcgtgtgt ttcagtggac      180

agcatctaca gctacaataa ctaaagaaaa acaagatcaa cctaagaaag atatctcaaa      240

ttatcaggtg gaacaagctc aagttcttct taagagagag aaggaaatcc caccaaccgt      300

tttccctaat cgcagccctt ggtgccagaa tccctatgtc tctgcacatc cttactgtcc      360

tctgattgaa ccacacaata catccaccgc tggaggcaga ttggatagac agcccaggac      420

tcggtcaacc agacctaatc gagcctcagg gtctaagaaa aagaagacat ctgagtcaca      480

aaagcaataa gcagtcaact caacctttaa agactttcag gattaagcat ttcctggcca      540

agaaacaaaa gcaaaatcgt cccattcccc agtggattcg gatgaaaact ggtaatacaa      600

tcaggtacaa ctccaaaagg agacaatgga gaagaa                                636


<210> 4409
<211> 1399
<212> DNA
<213> Homo sapiens

<400> 4409
cacaacgttc ccgtttgctt atagttgtca acgaccatga tctctggacc cacactacag       60

taacaagttt gtcagtcatt ttcagataag gtgcaaatca agggatggct ttgtccccac      120

ttcggcgcag gtgggacaga cttggggaag acgcagctga agagacaaat tctcaggaca      180

tgggaaagcg gaaccaccaa aaggagtgat gatcaacgat ctcatgataa atctggatgc      240

tagttctcat gcctcaggac atcctactgg gaacgacaca ccagctcctg ggatcagact      300

ttcatctact taggacccct ctttgcccag actactaaag ccagtcttca ctagccacga      360

atggctaccc aaaggaaaca cttggtgaaa gattttaatc cttacattac ctgctatatc      420

tgtaaagggt atctgatcaa gccaacaaca gtgacggaat gcctccatac attctgtaag      480

acttgtattg ttcagcactt tgaagatagc aatgattgcc caaggtgtgg caaccaagtt      540

catgagacaa atccattaga aatgttgagg ttggacaata cattagagga aattatattt      600

aagctggtcc ctggactacg agaacaagaa cttgagcgtg aatctgaatt ttggaagaaa      660

aataagcctc aagaaaatgg acaagatgat acttcaaaag ctgacaaacc gaaagtagat      720

gaagaaggtg atgaaaatga agatgataaa gattatcaca gaagtgaccc acaaattgct      780

atctgtctag attgtttacg aaataatggg caatcagggg acaatgtagt aaagggttta      840

atgaagaaat tcattcgatg ttctacacgt gtaactgtgg gaactattaa aaaatttcta      900

agtttaaaac taaaacttcc aagttcttat gagttggatg tgctgtgcaa tggtgaaatt      960

atggggaagg atcatactat ggaattcatc tacatgacaa gatggcgact aagaggcgaa     1020

aactttcggt gtctgaactg ctcagcttcg caagtctgct ctcaggatgg ccctttgtat     1080

cagtcatacc ctatggtact gcagtatcga ccaagaattg atttcggtta gaccaagggg     1140

cccagacctc actgagatga atcctgcact atttgtttac tcgtcaacag attgcacagt     1200

taacggtgtg tggactagag gaacacaacc agattttcag catgcaaata aggccattgt     1260

ctatctctaa attgtcagtt gcattcatgt tgtttctatt aggagcaaac caagtgccat     1320

tctgctactg aaccatctgc ataaggtatt tgtgttgtct caaagtgtgc aagtcatggt     1380

aaaaatcagt tagctgtgc                                                  1399


<210> 4410
<211> 2870
<212> DNA
<213> Homo sapiens

<400> 4410
ggagaacata ttgtgatgtt cgtgcctcag agctaaaact atgagtgaat ttcggattca       60

ccatgacgtc aatgaactgc ttagcctgct gcgtgtccac ggaggagatg gggctgaggt      120

ctacattgac ctgcttcaaa agaacaggac cccgtacgtc actaccactg tctctgctca      180

cagtgccaag gttaaaattg cagagttttc tcgtactcca gaagactttc taaagaaata      240

tgatgaactg aaatctaaaa atacaaggaa ccttgacccg ctggtgtacc tgttgtcaaa      300

gctcacggaa gacaaagaga ctctgcagta cttacaacag aatgcaaaag aaagagctga      360

gcttgcagcc gctgctgtgg gcagcagtac caccagcatc aacgtccctg ccgcggcctc      420

caagatctcc atgcaggagc ttgaggaact gaggaagcag cttggcagcg tggccacagg      480

ctccacgctg cagcagtctc tggaacttaa aagaaagatg cttcgagaca agcagaacaa      540

aaaaaattca ggccagcacc tccccatctt cccagcatgg gtgtatgaga gacctgccct      600

gatcggggat ttcctgattg gtgctggcat cagcacagac accgctttgc cgatagttct      660

tttgagatgg aatctcgctc tgtcgcccag gctgaagtgc agtggcgtga tctcggcaca      720

ctgcaacctc cacctcccag gcacgttgcc cctggcctcg caggagtcgg ccgtggtgga      780

ggacctgctg tacgtgctgg tgggcgtgga cgggaggtac gtcagtgctc agcccctggc      840

tgggaggcag agccggacct tcctcgtgga ccccaacctg gacctgtcca tcagggagct      900

ggtgcacagg atcctcccag tggccgccag ctactccgct gtgaccaggt tcattgaaga      960

gaagtcttcc ttcgagtacg ggcaggtgaa ccacgccctg gcggccgcca tgcgcaccct     1020

ggtgaaggag cacctgattc tggtgtcaca gctggagcag ctgcacaggc agggcctcct     1080

ttcgctgcag aagctctggt tctacatcca gccagccatg cgcaccatgg acatcctggc     1140

ctccctcgcc acctcggtgg acaaaggcga atgtcttggg gggtccacgc tgagcctgct     1200

ccacgacagg agcttcagct acacagggga cagccaggcg caggagctat gcctgtacct     1260

aaccaaggcg gccagtgctc cctacttcga ggttctggag aagtggatct acaggggcat     1320

catccacgac ccatacagtg agtttatggt cgaggagcac gagctgcgga aggagaggat     1380

ccaggaggat tacaacgaca agtactggga ccagcggtac accatcgtcc agcagcagat     1440

cccgtccttc ctgcagaaaa tggcggacaa gatcctcagc acaggaaaat atctaaatgt     1500

ggtcagagag tgtggccatg acgtcacctg cccggtggct aaagagatca tctacacgtt     1560

aaaagagcgg gcgtatgtgg agcagatcga gaaggcgttt aactacgcca gcaaggtgct     1620

gctggacttc ctgatggagg agaaggagct ggtggctcac ctcaggtcca tcaagcgcta     1680

cttcctcatg gaccagggcg acttcttcgt gcacttcatg gacctcgcgg aggaggagct     1740

ccggaagccg gtggaggaca tcacgccccc tcgcctggaa gcgctcctgg agctggcgct     1800

gcgcatgagc acggccaaca ctgacccctt caaggacgac ctcaagatcg acctgatgcc     1860

ccatgacctc atcactcagc tcttgcgcgt cctggccatc gagaccaagc aggagaaggc     1920

gatggcgcac gccgacccca cggagctggc gctgagcggc ctggaggcct tctctttcga     1980

ctacatcgtc aagtggcccc tttcgctcat catcaacagg aaagccctca ctcgctacca     2040

gatgctcttc aggcacatgt tctactgcaa gcacgtggag cggcagctct gcagcgtctg     2100

gatcagcaac aaaaccgcca agcagcactc gctgcactcc gcccagtggt ttgctggggc     2160

tttcactctg cggcagcgaa tgctcaactt cgtccagaat attcaatact acatgatgtt     2220

tgaagtgatg gaaccgacct ggcacatcct ggagaaaaac ctgaaatccg cctccaacat     2280

tgacgacgtc cttggccacc acacaggctt cctggacacc tgcctgaagg actgcatgct     2340

caccaacccc gagctgctga aggtcttctc caagctcatg tctgtgtgcg tcatgttcac     2400

caactgcatg cagaaattta cacagagcat gaaattagat ggcgagctgg gcgggcagac     2460

gctggagcac agcaccgtcc tggggctgcc cgcaggggcc gaggagcggg cccggaagga     2520

gctcgccagg aagcacctgg ctgagcacgc agacactgtg cagctggtgt ccggcttcga     2580

ggccaccatc aacaagtttg acaagaactt ctcagcccac ctgctggacc tcctggcccg     2640

gctgagcatc tatagcacca gtgactgtga gcacggcatg gccagcgtca tctccaggct     2700

tgacttcaat ggtttctaca cggagcgcct ggagcgcctg tctgcagaga ggagccagaa     2760

ggccaccccc caagtgcctg tcctgcgggg gcccccggct cctgcaccca gggtcgcagt     2820

caccgcacag tgagccctgg ctgtgacagg aaggaagggt gtggggtcag                2870


<210> 4411
<211> 2902
<212> DNA
<213> Homo sapiens

<400> 4411
attcctgccc tggtggagct tacattatag aagggaggtc cagaccatca ataaatatac       60

agcgaagctc caaggaaaaa cagagcaggg caaagagaag acagctatgg gaggtggttt      120

attttatata aattagccag acagtgcctc tgagaggtga tgtctaagca gggactcgga      180

gatgagggaa taagctaatg gatatctgaa gaaagaacct tccacatgga tgaagcatcg      240

catgcaaagc tcaaggaagg agcatgttta gtcaagtgcc taaagtggct ggagcagagt      300

gagtgagagt tgagaggtag aagatgaatt cggagaggga gcattggggc cagactatgt      360

agcctagtgg gccaagtgag gtcaggcctt taagaaggag cgtattgagg aagaaccatg      420

cacactactg ctagtgctag ggtgagaaag atgaggactg agaactgacc tggatttggg      480

atcttgggtg aatgagtgac atccgcaaga gtagtctctg ttgactggtt agggacagat      540

gtctgattaa ctgggagcac aggaagctgg ggcagtgact ctaggtaaca cgctcttgag      600

gcattggtat atgtaaaggg tcacaatgga aaggaaagct agcaggaggg caagggaatt      660

agggttttgt ttttgtgttt atttttggtg ctgggataaa cagcgtatgt gtcactgggt      720

agaaatgatc cagtaaagga aaaattgtga actttgttct ctcttaatat gtgtgtttcg      780

ttgattcatt cctgacttgt atctcccaca tcttatccct taattaagcc attcttcctc      840

ttgcataatt gcaaattatt atgatataaa tagctttgtt gtactctttt atgagtttta      900

cagggaggaa attgcataaa ctctctataa agtaatttct atgtttaaaa gcccttaagt      960

tctcccgccc catagcctga ccaaaaaagt cttactaaac aaaaatagga tacaaatgat     1020

ccatacacat catcctggct agagaagggt cagaaactac agtgttgtta gaaccaatag     1080

agcttaactt tatatctcac tggctttaat aaaaaacttt tctgagctat ttgacacaaa     1140

aatcactaag attaagaaaa tatcttaaca caggtggaaa tagtaaaagg atgtttgcat     1200

gaaaaccgtc aaatgtaata aacagcacta ttctctgata ataaaagatg aatctggctg     1260

tcagatgcaa ttttataata gcttcgacca tcatgtacgg caggagtatt tttttttatt     1320

tactatcgtt aagtttgtgg aaccagtgat tgttgtttta ctattttgtt aaggaaacct     1380

aaaacattct tagaatgtac agaaagaata tggtcattct tataggacca aagggcgtat     1440

caagtgagct gcttttgtaa ataccatgaa aatccaagtc tgacatggaa ttaaaatcat     1500

ctctactaca agatgcagaa aaaaaccaaa ctcttttttt tctatatcag agacttaaaa     1560

atattagtga tgaccaatgt gattagaagc tttaaaatcc taacatttat gtgaacaaaa     1620

atcttcctgt tttcagagac ttaagcatat catctgagca ttgaaaaaag ctcttaatag     1680

tacctttcag atttctcatc tgttttcaga tcccatatta aactccttgt ggaagaatga     1740

gaaagaaagc tactctaaat tttacagaat agaattcagg ctctttattt acaaaatgga     1800

gtgtgaacct tgctgtttac tcatctaccc cctcaagcaa ttgtgttttc cttccttatc     1860

agcacagacc atcacagttc caggatttgt ctgagatgct agccacctct gattgctatt     1920

cactggacac tcttgtgatt gtgatttaag attgtaggcc aggcatgagc caccgcgccc     1980

agccggcatg taaattttta tgtgacactt tttttttggt ggggggtggc aggggagagg     2040

gtctcactgt tgcccaggct agagtgcaga ggtgctgatc acagctcact gcagggcacg     2100

caccaccatg cccggctaag tttttgtatt ttttgtggag tcagggtctc actctgttgc     2160

ccatgctggt ctggaactcc tgggctcaag caattcaccc gccttggcat cccaaagtgc     2220

tgggattgca ggcatgagct actccgccct ggctgtgata ctctttaatt attctaatgc     2280

ttctaactta cgtcatggtg ccaatcctat ttatataata gaatcaatct catactctca     2340

gctgacaatg aggggtattt cattttttac ttgtatataa gattcctttt atataggatg     2400

aaatgcatac acactctgca tagaaattct tatgtgtttg tatattactc cattcaatca     2460

tactatgatt ccaagttaag aactcctaga taaattagcg tctgtagctg taacagttga     2520

ggctttcaat tcaaatgtca gataacattc ttctgtgtat tgtattattt tctgcagtaa     2580

ttcaaatctt tattgagttg aggtttgctc acttactata aggtagaatg aggtgatcta     2640

agtaggtttt gtttaaatac atgtgtcttc tccccatcag agtaaaagaa gccgaagagg     2700

tgtgtagaca gaagaaagga aaatcacttt ataaaataaa accaagacat gactctggaa     2760

ttaaagcaaa gataagcatg aaaacttgaa caatgaaaag cagaatgaaa atgagtcatt     2820

gcaacgactt tcacaaaatt cagctgacct gagagtggga gggaaactac cgtcattctg     2880

ctcatgtttc ttcttgacct ct                                              2902


<210> 4412
<211> 2704
<212> DNA
<213> Homo sapiens

<400> 4412
gcctgaactg tttgtacctc tgggccatat tgcagaaccc tgcccttctt tgttgactga       60

ggaaagctcg ctccctgccc aggtttttca ttgttgatcg aaattaacac caggtggtga      120

atagagcccc tcctaaggtt gctcaggata aatcatttat taaataggtc tgcttatcag      180

gaggggcgtg aaggctccca aaaggaaatg ctggcacctg ggcccagaag ccagggcctc      240

taactcctgg ggttgatttc ttcagtgaag ttgcacccta caaagggaat atggccaaag      300

cggcactcaa ctgaaggctg atatcaggcg attagacagc catgcattct gcgtttgtct      360

ggaatggatt gtagagagat ggacttatat gaggactacc agtccccgtt tgattttgat      420

gcaggagtga acaaaagcta tctctacttg tctcctagtg gaaattcatc tccacccgga      480

tcacctactc ttcagaaatt tggtctgctg agaacagacc cagtccctga ggaaggagaa      540

gatgttgctg ccacgatcag tgccacagag accctctcgg aagaggagca ggaagagcta      600

agaagagaac ttgcaaaggt agaagaagaa atccagactc tgtctcaagt gttagcagca      660

aaagagaagc atctagcaga gatcaagcgg aaacttggaa tcaattctct acaggaacta      720

aaacagaaca ttgccaaagg gtggcaagac gtgacagcaa catctgcgag gagcaagctt      780

ctagcagcag aaaccgaact gctctgtctt ctgtattgag agccatctgc agagctgtta      840

caagaagaca tctgaaacct tatcccaggc tggacagaag gcctcagctg ctttttcgtc      900

tgttggctca gtcatcacca aaaagctgga agatgtaaaa ttgcaagcct tttcacattc      960

ctttagtata cgttccattc agcattcaat tagcatgcct gctatgagaa actccccaac     1020

ttttaaatca tttgaagaaa aggtcgaaaa cttaaagtct aaagtagggg gaaccaagcc     1080

tgctggtggt gattttggag aagtcttgaa ttcggctgca aatgctagtg ccaccaccac     1140

ggagcctctt ccagaaaaga cacaggagag cctgtgagat tcctaccttt gttctgctac     1200

ccactgccag atgctgcaag cgaggtccaa gcacatcttg tcaacatgca ttgccatgaa     1260

tttctaccag atgtgctttt atttagcttt acatattcct ttgaccaaat agtttgtggg     1320

ttaaacaaaa tgaaaatatc ttcacctcta ttcttgggaa acacccttta gtgtacattt     1380

atgttccttt atttaggaaa caccattata aaaacactta tagtaaatgg ggacattcac     1440

tataatgatc taagaagcta cagattgtca tagttgtttt cctgctttac aaaattgctc     1500

cagatctgga atgccagttt gacctttgtc ttctataata tttccttttt ttcccctctt     1560

tgaatctctg tatatttgat tcttaactaa aattgttctc ttaaatattc tgaatcctgg     1620

taattaaaag tttgggtgta ttttctttac ctccaaggaa agaactacta gctacaaaaa     1680

atattttgga ataagcattg ttttggtata aggtacatat tttggttgaa gacaccagac     1740

tgaagtaaac agctgtgcat ccaatttatt atagttttgt aagtaacaat atgtaatcaa     1800

acttctaggt gacttgagag tggaacctcc tatatcatta tttagcaccg tttgtgacag     1860

taaccatttc agtgtattgt ttattatacc acttatatca acttattttt caccaggtta     1920

aaattttaat ttctacaaaa taacattctg aatcaagcac actgtatgtt cagtaggttg     1980

aactatgaac actgtcatca atgttcagtt caaaagcctg aaagtttaga tctagaagct     2040

ggtaaaaatg acaatatcaa tcacattagg ggaaccattg ttgtcttcac ttaatccatt     2100

tagcactatt taaaataagc acaccaagtt atatgactaa tataacttga aaatttttta     2160

tactgagggg ttggtgataa ctcttgagga tgtaatgcat taataaaaat caactcatca     2220

ttttctactt gttttcaatg tgttggaaac tgtaaaatga tactgtagaa cctgtctcct     2280

actttgaaaa ctgaatgtca gggctgagtg aatcaaagtg tctagacata tttgcataga     2340

ggccaaggta ttctattcta ataactgctt actcaacact accacctttt ccttatactg     2400

tatatgatta tggcctacaa tgttgtattt gttatttatt aaattgtgat tgttttatta     2460

ttgtttatgc caaatgttaa ctgccaagct tggagtgacc taaagcattt tttaaaagca     2520

tggctagatt tacttcagta taaattatct tatgaaaacc aaattttaaa agccacaggt     2580

gttgattgtt ataaaataac atgctgccat tcttgattgc tagagttttt gttagtactt     2640

tggatgcaat taaaactatg tgctatcaca tgtgaaaagc ttaataaatt ccatctatca     2700

gtag                                                                  2704


<210> 4413
<211> 5219
<212> DNA
<213> Homo sapiens

<400> 4413
acgcgcgcag ccagcccttc cccctccggc tcccgcaccg ccggccgcct cccctcgccc       60

tcctactctc ccctccctgc tccttcgctt tttcctcctc ctcctctccc ggccccggct      120

gccagcacca tgtccgcagg gggagatttt gggaatccac tgagaaaatt caagttggtg      180

ttcttggggg agcagagcgt cgggaagacg tctctgatta cgaggttcat gtacgacagc      240

ttcgacaaca cataccaggc aaccattggg attgacttct tgtcaaaaac catgtacttg      300

gaggaccgca cggtgcgact gcagctctgg gacacagctg gtcaggagag gttccgcagc      360

ctgatcccca gctacatccg ggactccacg gtggctgtgg tggtgtacga catcacaaat      420

ctcaactcct tccaacagac ctctaagtgg atcgacgacg tcaggacaga gaggggcagt      480

gatgttatca tcatgctggt gggcaacaag acggacctgg ctgataagag gcagataacc      540

atcgaggagg gggagcagcg cgccaaagaa ctgagcgtca tgttcattga gaccagtgcg      600

aagactggct acaacgtgaa gcagcttttt cgacgtgtgg cgtcggctct acccggaatg      660

gagaatgtcc aggagaaaag caaagaaggg atgatcgaca tcaagctgga caaaccccag      720

gagcccccgg ccagcgaggg cggctgctcc tgctaatgca gagccgacct gtggcttccc      780

atgacactcc ttgcttgttg tgttgcttcc tattggctag cttcctaagg ggggagggaa      840

ccgagttatc aagatgggag gatttttctt ttctctctgt ctttaggagt agggtgggat      900

ggggagggag gctgggcatc agggatcaca tcactcttaa cggctgttac ttaaacaact      960

attttttggt ttggttgtaa tatattgtac tttattaaga ttgccaaaaa ctgttaaaat     1020

ttaaaaaaaa tttaaatcat gtgtatacaa ttttttgcca gataaaaatg tagtcatttt     1080

tatttgaaag atgtgctttt tgtttttgta tatttgtaaa cttatagaga accttttcca     1140

cacacctcct ccttcctgtt ctctttgaac cattcatcac ctctgccttc ctcctatccc     1200

cagcccaata aattaaaaca attaactgag caaattaatt aggcttcagt ctggggccat     1260

ctggccccac tctctaggcc ctactccagt taaatcaaac attggttgaa cacatcagcc     1320

tctgaaaagg tagctctgac tcttgtcttt ccatggccag agtgggtcgt caacctcgtg     1380

tggagctgag accaaggtct gtgggctcta ggcagcccgg cagcagcccc cagaggaact     1440

gctcccacct ctccttctct ttccctgaaa agccttgaag ggggttgagg gtacaggcaa     1500

ccttgtgttc tctgtgccct cagggactgg cagagcaaga ggccatcaga aggacgaggt     1560

gctgttggca attgcagctg cgtggtgcgt ggtttataga ctggggtgcc atgtgtactt     1620

ctgaaaatat tttaaccagc ccacccagca gtcagtacac atgcctgggc caagtctaag     1680

aaactcagtg tgtgatgttg ggcagtgtgc catcctgaag ccttcctcct ggatgtcagg     1740

gaagctggac cacctggagt tgatcctctg tgatggggag gcgggggggg gggggggtgt     1800

tgtctgcaga accaccacct tgaaagatcc atgttcttag agcctcagct gctaatattg     1860

ttgagtgctt tctggaaaag ctgatttgtt gctatgtttt caccccagtg gcatggcgca     1920

gttgaagtct ttgtggacat atctttgtgg ctactgtggc tgcgctgtgg tcacctgagg     1980

atgtggttca ggtggggtct ccagaaggct gcttgccccc agagagccat ctcttccatt     2040

tttgattcat tcctgagaat ggcttagtcc tgagaatctg caaagtctct gaagagaact     2100

ctctcttccc actaagtgag tctggccaaa atgtaaaccc caccctccct gctgtcattg     2160

gctctccctc caggctgctg ctgggcatgt catagatggg atgaatgacc atctggggta     2220

tggtgggctg aactccacaa ggtcgttgga atgaattttg aaacttctca gaaattaatc     2280

tgaaatggca ggcagtaagt gcagcagaat ctggcaggac tgatatttgt gcagtgggcc     2340

tgccacacac cctctgccta ggaggctgta tgccagagct catctctagc aaggaattta     2400

tcttcaggtg aagaagagag gaagcaggat cccactgagc acctcttgca gaaggcaagg     2460

accaatgttt gaacgtgttt cagatgtcat gtgtttagtt tttatatgtg tgtacataat     2520

tatatataga gatagacttg tgtatacacc ttccacaaac acatcctcac ggagatacat     2580

gtgctcaatg tatattcttg tttctcctgc tctcaagttg gaacttgcat tgtgataagt     2640

tttggaaatt caaaagtact gcaacgtgtt gaaataagaa atacttaata ttgtcaaata     2700

acttgtgatt gtcttgccat caataaaata atgcatagtt gtgttaaact acaggcaaac     2760

atagcccacg ggaatatctc caccatttct ctatgtactt tatatgcacg ggtgtgcatg     2820

cctgtgtggg ccagtgtccc cccaccatgg gcacaccccc aagtggtgct tgttggaaga     2880

gtgcttactt acctcgagag aatttacagg agtccacatg acagtgtcct gcctggttgg     2940

cagcgggggc catcacctgt ggcctctgag accgccccat ttacaggaat ctgcactggg     3000

tctcagtgaa tgaacgtatg gtagattttt attttcttgg cactaaagat tagctttttt     3060

aaaaaaacat cccataaaac agtagaaact cagttccctt ctcaggggca cacacatcca     3120

aggcaccgtg gactgtgttt ccatcctggc ctagaggagc agtaaaagat agcatttggt     3180

ttgacatggc cttagtgagt cctgcctttc ctagcatgca cacaacatcc tctctttgag     3240

tttgggttct ccccagcccc ttggcctctg aggctgaggg tggcttcctc ccatcctccc     3300

atctcagtgg ttccatggcg ctcccttcgg cacgtgcggt ttccgcccct cccttcctgg     3360

ggtgtggaaa ggcagccaga cctctttttc agaagttgtt ggttccctga tttttgtctt     3420

gagcaggcac catccctgtc cccttgcttg caggtagaat tggcacagag ttaaggttcc     3480

ataataaact gttaggtgct cttgaagaag atgtcatggc attgcctcag caccccagca     3540

agagcattgc atctttgctg aatccagatg ggttagcaga gggcaaattg gaggattcct     3600

ttgaggaaat gttctcaatt gagcaattca gtccctctcc ccaaagacta gacgtgacct     3660

ggcagattag caggatcctc ttggccttct tttttgggga tggtgggagt gaagggggtg     3720

aatcttaaaa gcttatcaac aaagctcctg ttctgcaggc atcaggaaag ttgagtgtaa     3780

gatggaaaaa gcaaacagcc tatttacaag tggaaacaca ttggttctga tcactcctaa     3840

cttgctgggt gatcatacat acatcaacat gaaggtgtga catcagaatc atgagcacca     3900

tggctgcagt tgtgtgatcc aaggctagtt ggcttggtag ctgttggcag cagtttccct     3960

tggtcagagg cctccttgct atctatcgct gctctcttct tgtcatcctt aaacattcag     4020

tcatgttccc aggtctgagg ggagcaatgg ccagaccagt ttcagtatct ctggcaacag     4080

aaacaaggat tgaaatggtg gtagttaaga gtgcagacac atctggggtg caacgtctgc     4140

atcatcctgg tggctagcca gtgcggggag gccctgccct gggataccag ttgtgacaat     4200

aaagggatgg ccctcctggc ttcagcatcc tgcaggtaga gcagcctcat tccttcacaa     4260

gatggaaggc aggtgaggat gtcaggatga gatgggacca ggtagccgag gacagtgagg     4320

catgtctgag ccacttgagg ggcagctgaa cagaaggatg tctgtgtgca tcaaccgagc     4380

agattgtgcg cacactcgtt tccgaactgc ctctccccaa agaatgtgag gcattgtcac     4440

cttgttacag ctatgtgaag cagagctgtc acaacttttc ctgtctacag gcaggaaaac     4500

caggatggag aagggcaact tgcttattaa gatcacccag caagttagga gtgatcagaa     4560

ccagtgaagt ttccattttt catccattgc tgccctgtgt gtgaacaaat gtgactccat     4620

atttattaca cagcaaggac tgctgtgtgt gggtgtgttc ctcagaccat ctctactctt     4680

tttggttagg acactaggtt cttcccagca tatgagtgag aatattggtg gtattttggg     4740

ctcctctact gcacaagggc cagtccccaa gtctactctg attgattgtc atgggcaccc     4800

acacagatca ggacaccctt tgaatttttg tttgacatga actatttagg tgttccaaaa     4860

ccttgggatc tcaatgtgca aactccttgg actccagacc cctgtctggt tggcactccc     4920

agcagtgtgt ggtttcatca ggaaatcctt gcagcagggg tttagatggt tccttcagga     4980

ggtgggaagc ctccatagca ttgaaggcca gcctgcatct cgcggtgtgt gtccacttct     5040

cccctcactt tcccctcacc catcccttta aagtgattgg ctgtgaggag cacagagggt     5100

ggcaattcca tctgttatgg gctcagaaga catagccgcc atgttgattt cacattaaac     5160

tgtgtaaaat gtggaaaaga ctcagcatgt tggtcaaaca ataaactgtc ctaattctc      5219


<210> 4414
<211> 1685
<212> DNA
<213> Homo sapiens

<400> 4414
cgaggaagga cctggtgttt tgatgaccgc tgtcctgtct agcagatact tgcacggttt       60

acagaaattc ggtccctggg tcgtgtcagg aaactggaaa aaaggtcata agcatgaagc      120

gcagttcagt ttccagcggt ggtgctggcc gcctctccat gcaggagtta agatcccagg      180

atgtaaataa acaaggcctc tatacccctc aaaccaaaga gaaaccaacc tttggaaagt      240

tgagtataaa caaaccgaca tctgaaagaa aagtctcgct atttggcaaa agaactagtg      300

gacatggatc ccggaatagt caacttggta tattttccag ttctgagaaa atcaaggacc      360

cgagaccact taatgacaaa gcattcattc agcagtgtat tcgacaactc tgtgagtttc      420

ttacagaaaa tggttatgca cataatgtgt ccatgaaatc tctacaagct ccctctgtta      480

aagacttcct gaagatcttc acatttcttt atggcttcct gtgcccctca tacgaacttc      540

ctgacacaaa gtttgaagaa gaggttccaa gaatctttaa agaccttggg tatccttttg      600

cactatccaa aagctccatg tacacagtgg gggctcctca tacatggcct cacattgtgg      660

cagccttagt ttggctaata gactgcatca agatacatac tgccatgaaa gaaagctcac      720

ctttatttga tgatgggcag ccttggggag aagaaactga agatggaatt atgcataata      780

agttgttttt ggactacacc ataaaatgct atgagagttt tatgagtggt gccgacagct      840

ttgatgagat gaatgcagag ctgcagtcaa aactgaagga tttatttaat gtggatgctt      900

ttaagctgga atcattagaa gcaaaaaaca gagcattgaa tgaacagatt gcaagattgg      960

aacaagaaag agaaaaagaa ccgaatcgtc tagagtcgtt gagaaaactg aaggcttcct     1020

tacaaggaga tgttcaaaag tatcaggcat acatgagcaa tttggagtct cattcagcca     1080

ttcttgacca gaaattaaat ggtctcaatg aggaaattgc tagagtagaa ctagaatgtg     1140

aaacaataaa acaggagaac actcgactac agaatatcat tgacaaccag aagtactcag     1200

ttgcagacat tgagcgaata aatcatgaaa gaaatgaatt gcagcagact attaataaat     1260

taaccaagga cctggaagct gaacaacaga agttgtggaa tgaggagtta aaatatgcca     1320

gaggcaaaga agcgattgaa acacaattag cagagtatca caaattggct agaaaattaa     1380

aacttattcc taaaggtgct gagaattcca aaggttatga ctttgaaatt aagtttaatc     1440

ccgaggctgg tgccaactgc cttgtcaaat acagggctca agtttatgta cctcttaagg     1500

aactcctgaa tgaaactgaa gaagaaatta ataaagccct aaataaaaaa atgggtttgg     1560

aggatacttt agaacaattg aatgcaatga taacagaaag caagagaagt gtgagaactc     1620

tgaaagaaga agttcaaaag ctggatgatc tttaccaaca aaaaattaag aaagaaagaa     1680

agaaa                                                                 1685


<210> 4415
<211> 2676
<212> DNA
<213> Homo sapiens

<400> 4415
acgcgtttcc cattggtgac atcttggcgg gcccggcaat ggcacttcct cctctgcacc       60

ccgtgaccca cgtccggctg ccggtcttgg atcacgaggc ctccgcttcc cggactccgg      120

accccgcgcc tcctcggggc cgacgggcca gtccctggcg tggttgagaa caaaaacatg      180

cacctggagt ttccccggag ccctctgcgt ggttgagctt cggtggaatt tcggggctct      240

tggctgccag ccgcgcttgc ctggtagcaa cagaaaccag tcctgctcgc ctccgtggac      300

atttcattac catccagaag tgtctcccac tgaaggcatc cgtggttgtt tttaagccac      360

aaaaaagcca cacccaagat cacctgacac ccaccctgac aagtgtccat gatgctgggc      420

cctgagggag gtgaaggctt tgtggtcaag ctccgtggcc tgccctggtc ctgctctgtt      480

gaggacgtgc agaacttcct ctctgactgc acgattcatg atggggccgc aggtgtccat      540

ttcatctaca ctagagaggg caggcagagt ggtgaggctt ttgttgaact tggatcagaa      600

gatgatgtaa aaatggccct gaaaaaagac agggaaagca tgggacaccg gtacattgag      660

gtgttcaagt cccacagaac cgagatggat tgggtgttga agcacagtgg tcccaacagt      720

gccgacagcg ccaacgatgg cttcgtgcgg cttcgaggac tcccatttgg atgcacaaag      780

gaagaaattg ttcagttctt ctcagggttg gaaattgtgc caaacgggat cacattgcct      840

gtggaccccg aaggcaagat tacaggggaa gcgttcgtgc agtttgcctc gcaggagtta      900

gctgagaagg ctctagggaa acacaaggag aggatagggc acaggtacat tgaggtgttt      960

aagagcagcc aggaggaagt taggtcatac tcagatcccc ctctgaagtt catgtccgtg     1020

cagcggccag ggccctatga ccggcccggg actgccagga ggtacattgg catcgtgaag     1080

caggcaggcc tggaaaggat gaggcctggt gcctacagca caggctacgg gggctacgag     1140

gagtacagtg gcctcagtga tggctacggc ttcaccaccg acctgttcgg gagagacctc     1200

agctactgtc tctccggaat gtatgaccac agatacggcg acagtgagtt cacagtgcag     1260

agcaccacag gccactgtgt ccacatgagg ggcctgccgt acaaagcgac cgagaacgac     1320

atttacaact tcttctctcc tctcaaccct gtgagagtcc atattgagat tggcccagat     1380

ggaagagtga cgggtgaagc agatgttgag tttgctactc atgaagaagc tgtggcagct     1440

atgtccaaag acagggccaa tatgcagcac agatatatag aactcttctt gaattcaaca     1500

acaggggcca gcaatggggc gtatagcagc caggtgatgc aaggcatggg ggtgtctgct     1560

gcccaggcca cttacagtgg cctggagagc cagtcagtga gtggctgtta cggggccggc     1620

tacagtgggc agaacagcat gggtggctat gactagtttt gttaggaaca tttgagttac     1680

ttcaatcatt ttcacaggca gccaacaagc aattaagagc agttataata gaggaagctg     1740

ggggacccat tttgcaccat gagtttgtga aaaatctgga ttaaaaaatt acctcttcag     1800

tgttttctca tgcaaaattt tcttctagca tgtgataatg agtaaactaa aactattttc     1860

agcttttctc aattaacatt ttggtagtat acttcagagt gatgttatct aagtttaagt     1920

agtttaagta tgttaaatgt ggatctttta caccacatca cagtgaacac actggggaga     1980

cgtgcttttt tggaaaactc aaaggtgcta gctccctgat tcaaagaaat atttctcatg     2040

tttgttcatt ctagtttata ttttcattta aaatccttta ggttaagttt aagcttttta     2100

aaagttagtt ttgagaattg agacacaata ctaatactgt aggaattggt gaggccttga     2160

cttaaaactt tctttgtact gtgatttcct tttgggtgta ttttgctaag tgaaacttgt     2220

taaatttttt gttaactaaa tttttttctt aaaataaaga ctttttcaca atgactggca     2280

cagattactc agcaaaagat agcaaaacgg gtggttgaag ataattcatt ttaatcgtaa     2340

tgtattttag tgtgaattta aaaatttcat acatcaaatc tatgatctcc cttatattct     2400

tatgatgagg ctaaataaaa gtctaataaa aatgttaaat atgtgaatgg tggaaatggt     2460

gactagcagc acacattctg ggaagcatca aatagacaca cggccccagc cacctgcaac     2520

ttatgtgcac tgttgtaaac cattcagaat tttcctgcta ggcccttgat gctggagtca     2580

catctgttga tagctggaga actttagttt caagtactac attgtgaaag caattatttt     2640

gtttctagtt tttataaaat gctgatttaa actttt                               2676


<210> 4416
<211> 1672
<212> DNA
<213> Homo sapiens

<400> 4416
atcccgcccc cgttgccggg atacgccgcg gcgcacggca gttagtgggt aggcctgaga       60

gccgaggaaa actgagcgtg ggcctcagaa agaagttaag gcacccgcga gccgggcaac      120

tgccctcctt ccgcgccggc ggagcgatta aagtgaagaa acaatggcca gcaatcacaa      180

atcttcagca gctcgccctg tttcaagagg tggagttggg ttaacaggaa ggcctccttc      240

tgggatacga cccctatcag gaaatattcg agtggcaact gcaatgccac ctgggacagc      300

aagaccaggt tctcgtggtt gtcccatagg gactggtgga gttctgtctt ctcaaatcaa      360

agttgcccat cgccctgtaa cacaacaagg tttgactgga atgaaaactg ggacgaaagg      420

tccccagagg caaattttag acaaatctta ctatcttggg cttcttagaa gtaaaataag      480

tgaacttaca actgaagtta ataaacttca gaagggaata gaaatgtaca atcaagagaa      540

ttcagtatat ttgtcatatg aaaagagggc tgagacttta gctgttgaga taaaagagct      600

tcaaggacaa ctagcagact acaacatgtt ggtagataaa cttaatacca acactgaaat      660

ggaagaagta atgaatgatt acaatatgct taaagctcaa aatgatcgag aaacacaaag      720

tttggatgtc atatttactg aaagacaagc gaaagaaaaa caaatcagaa gtgtcgaaga      780

agaaattgaa caggaaaaac aagcaacaga tgacattatc aaaaatatgt cttttgaaaa      840

ccaagtcaag tacctagaga tgaaaaccac aaatgagaaa ctgttacagg aattagatac      900

acttcaacaa caattggatt cacagaacat gaaaaaagag agcctggaag cagaaatagc      960

tcactcccag gtgaaacagg aggcggtatt gctgcatgaa aaactttatg agttggagtc     1020

ccatcgagat caaatgattg cagaagacaa aagcatagga tctccaatgg aagagagaga     1080

gaaattactt aagcagatta aagatgataa tcaggaaata gccagcatgg aaagacagtt     1140

aacagataca aaagaaaaga taaatcagtt tattgaagaa attagacaac ttgacatgga     1200

tttagaggaa caccaaggtg aaatgaacca gaaatacaag gagctaaaga aaagggagga     1260

acatatggac acttttattg agacttttga ggaaacaaag aatcaggaac tgaaacgaaa     1320

ggcacagata gaagccaaca ttgttgcact cttggagcac tgcagtcgaa atataaatcg     1380

tatagaacag atatcctcta tcaccaatca agagctaaag atgatgcagg atgacctcaa     1440

ttttaaatct actgaagtgc agaaatcaca aagtacagct cagaatttga cttcagacat     1500

tcaacgtctg cagttggatc tgcagaaaat ggagcttcta gaaagtaaga tgactgaaga     1560

acagcattct ctaaaaagca aaattaagca aatgacaact gatctggaga tatataatga     1620

tttgccagct ttaaaatcat caggtgaaaa aaaaaaaaaa aaaaaaaaaa aa             1672


<210> 4417
<211> 1892
<212> DNA
<213> Homo sapiens

<400> 4417
agtttcgggt ggcccagcca actttcatgc cagccgtcct cagcccttcc tggtgctggg       60

tctgccaggc tcatggtcag ccaggcctgg ggccctggag aggtcctctg catcttgaat      120

tctgtggagc accatgactt gtggatctta ctgtggtggc cgcgccttca gctgcatctc      180

ggcctgcggg ccccggcccg gccgctgctg catcaccgcc gccccctacc gtggcatctc      240

ctgctaccgc ggcctcaccg ggggcttcgg cagccacagc gtgtgcggag gctttcgggc      300

cggctcctgc ggacgcagct tcggctaccg ctccgggggc gtgtgcgggc ccagtccccc      360

atgcatcacc accgtgtcgg tcaacgagag cctcctcacg cccctcaacc tggagatcga      420

ccccaacgcg cagtgcgtga agcaggagga gaaggagcag atcaagtccc tcaacagcag      480

gttcgcggcc ttcatcgaca aggtgcgctt cctggagcag cagaacaaac tgctggagac      540

aaagctgcag ttctaccaga accgcgagtg ttgccagagc aacctggagc ccctgtttga      600

gggctacatc gagactctgc ggcgggaggc cgagtgcgtg gaggccgaca gcgggaggct      660

ggcctcagag cttaaccacg tgcaggaggt gctggagggc tacaagaaga agtatgagga      720

ggaggtttct ctgagagcaa cagctgagaa cgagtttgtg gctctgaaga aggatgtgga      780

ctgcgcctac ctccgcaaat cagacctgga ggccaatgtg gaggccctga tccaggagat      840

cgacttcctg aggcggctgt atgaggagga gatccgcgtt ctccagtccc acatctcaga      900

cacctccgtg gttgtcaagc tggacaacag ccgggacctg aacatggact gcatcattgc      960

cgagatcaag gcacagtacg atgacattgt cacccgtagc cgggctgagg ccgagtcctg     1020

gtaccgcagc aagtgtgagg agatgaaggc cacggtgatc aggcacgggg agaccctgcg     1080

ccgcaccaag gaggagatca acgagctgaa ccgcatgatc cagaggctga cggctgaggt     1140

ggagaatgcc aagtgccaga attccaagct ggaggctgcg gtggctcagt ctgagcagca     1200

gggtgaggcg gccctcagcg atgcccgctg caagttggcc gagctggagg gtgccctgca     1260

gaaggccaag caggacatgg cctgcctgat cagggagtac caggaggtga tgaactccaa     1320

gctgggcctg gacatcgaga tcgccaccta caggcgcctg ctggagggcg aggagcagag     1380

gctgtgcgag ggcgtcggct cggtgaatgt ctgcgtcagc agctcccgcg gtggcgttgt     1440

ctgtggcgat ctctgcgcct ccactactgc ccctgttgtc tccaccagag tcagtagcgt     1500

ccccagcaac agcaacgtgg tggtgggcac tactaacgcc tgcgccccct ccgcccgggt     1560

tggcgtctgc ggcggcagct gtaagaggtg ctaggaggct gccgcctccg ccagcgcctg     1620

tcgccgtcac tctccaccca gccagtacct cgcgccacca gaacgcgccg cccgcgccgg     1680

cctcccaata gccgccgccc gctgcctgca ctctaagcgc cctccccacc gctccgctcc     1740

gggagccatc cccggtcgca ggagtccggg gagggccggg aggcgccatg gtctctctct     1800

gtagcctttc ctggtagtca atttgttgtc ccgaggattc atctttttct tccgcctgcc     1860

ttctgttttt tttgctgtat acattggtct tg                                   1892


<210> 4418
<211> 2502
<212> DNA
<213> Homo sapiens

<400> 4418
atgtgtacca tgcataaaga tgaaaaggcg aagcgagaag tgtcttcctg gactgtggaa       60

ggtgatatta atactgaccc atgggcaggt tatcgatata ctggtaaact cagaccacat      120

tatccactga tgccaacaag gccagtgcca agttatattc aaagaccaga ttatgctgat      180

catcccttag gaatgtctga atctgaacag gctcttaaag gtacttctca gattaaatta      240

ctctcatctg aagatataga agggatgcga cttgtatgta ggcttgctag agaagttttg      300

gatgttgctg ccggcatgat taaaccaggt gtaactactg aagaaataga tcacgctgta      360

cacttagcat gtattgcaag aaattgctac ccttctcccc tgaattatta taatttccca      420

aagtcttgtt gtacctcagt gaatgaagtc atttgccatg gaataccaga cagaaggccc      480

ttacaagaag gtgacattgt taatgtggat atcactcttt atcgcaatgg ttatcatggg      540

gacctgaatg agacattttt tgttggagaa gtggatgatg gagcacggaa acttgttcag      600

accacatatg agtgcctgat gcaagccatt gatgcagtga agcctggtgt tcggtacaga      660

gaattgggaa acattatcca gaagcatgcc caagcaaatg ggttttcagt tgttcgaagc      720

tattgtgggc atggaatcca caagcttttt catacagctc ccaatgtacc ccactatgct      780

aaaaataaag cagttggagt gatgaagtcg ggccatgtat ttacaattga gccaatgatt      840

tgtgaaggcg gatggcagga tgaaacctgg ccagatggtt ggactgcggt gacaagagac      900

ggaaagcggt ctgctcagtt tgagcacacc ctcctggtca cagacactgg ctgtgaaatc      960

ctaacccggc gacttgacag tgcacggcct cacttcatgt ctcaatttta atttctccca     1020

agatggcaca tctcagtacc ttcttactgt gctatgcatt ttattgagag tacagaaagg     1080

aagaggaacc tttttttaat cacttgtttt gttttgacta tagataagaa aggactacag     1140

catttgatgt gtgtcctcaa gaacttgtct tgggtctgaa aaagctgaga agaataaagg     1200

aaacattgct caactcttca gccccctccc cctgcacacc tgttttctca tttgcccttt     1260

gagcactttt acttaaactt gcttgtagtt gcttttatca ctgccgcaaa acagccatca     1320

agagccatct gctttccagg tgaacattgg aaatgagaat ctttgaaact tagcaatatg     1380

tgttgcacca gattttttaa attatatata tggaaatata tatgtataca ttttaagttc     1440

tgtatacata attaccaaac actatgtgac ctggagtttg tgttgtttct gctctgacag     1500

gtttatatgt tcttacaaat ggatccatag tttgcagtga tttaattcct ggttgggatt     1560

tggcctcccc tctcccccat gctaattatt tacccttgta attgtgcata gggaagcact     1620

cacccaatga gactttctcc aatgtggact ctgtgtgtca gtgaatgaat gtagtaaaat     1680

tcactttgga aggttatcag gcttttaaaa atctagttta tggcaaaaat agccattttc     1740

caagtggtgg ctgactgttg cagggaatga gaatttcata atacactgct atttcagacc     1800

tctgtttggt cagaaatgga aaagaaaaag ccccctttct tcccttttct gttttacttc     1860

aagggcatac cttggaggtg ctcagagaag cgtgaagttt gcactatggt ggaggatggg     1920

gaaagagttc taaagtgtct ccagctgtga acccaggagg tcaagtgggc tattaaaatc     1980

taacgttgag taaatgtgat agtgatgaga aaggaatttt gtgtactgta accttgcagt     2040

agagatgcag ctgtccttcg tgtgtggaaa cacacctctc ctttacatag ttgggaacct     2100

cattagaaat gacctcagct gccccatatc tacgttcctt tcagcagttg tccaagtagg     2160

agtgtatcca gtgaagacat atcaaatcac aaagtcattg tcattagagt gtacttgatt     2220

actgggcatc cttgtaatat aatttcatac cactgacaca ttatacttgt aagagaacat     2280

ctttcccaga gtgcctcaga ccttattgct ttaaaatata ataatgtttt cattactttt     2340

attatttgaa tgatttagta aagttgactg aatctggtat agactttggg agtatgtgtg     2400

tgaagttttt atcaaactgt aatatttgtg aatggaatgc cttgcaatat gaatgttaat     2460

ataatgtgta aagggagatt aaaaagtttg aatgattatc ct                        2502


<210> 4419
<211> 3270
<212> DNA
<213> Homo sapiens

<400> 4419
attgcatgta aaatgggaca ggaacacgca cctcggttca tgtgcttgag gagtgtttag       60

tgagcacctg ctatgcgcca ggcctttggg cagtggacac agggatatgg ccgggatgat      120

agacaggttc agccctgcca acacaggcat ccggtcttgg gatgtcgatc ctggcgtctg      180

caaccttgat gaacagctca aggtctttgt gtcccgacac tctgccacct tctccagcat      240

tgtgaaaggc cagcggagcc tgcaccaccg tggagacaac ctggagaccc tggtcctcct      300

gaacccatca gacaagtccc tgtatgatga gctccggaac cttctgttgg accctgcctc      360

tcacaagcta ctggtgttgg ctgggccctg cctggaggag acgggggagc tgctgctaca      420

gacagggggc ttctcgcctc accacttcct ccaggtcctg aaggacagag agatccggga      480

catcctggcc accacgcccc cacctgtgca gccgcccata ctcaccatca cctgccccac      540

cttcggtgac tgggctcagc tggcacccgc tgtgcctggc cttcaggggg cgctccggct      600

ccagctgcgg ctgaaccccc cggcgcagct gcccaactct gagggcctgt gcgaattcct      660

ggagtacgtg gctgagtctc tggagccacc gtcccccttc gagctgctgg agcccccgac      720

ctccgggggc ttcctcaggc tgggccggcc ctgctgctac atcttccctg gaggcctcgg      780

ggatgccgcc ttcttcgccg tcaatggctt cactgtgctg gtcaacggtg gctcaaaccc      840

caagtccagt ttctggaagc tggtgcggca cctggaccgc gtggatgccg tgctggtgac      900

ccaccctggc gccgacagcc tccccggcct caacagcctg ctgcggcgca aactggcgga      960

gcgctccgag gtggctgctg gtgggggctc ctgggacgac aggctgcgca ggctcatctc     1020

ccccaacctg ggggtcgtgt tcttcaacgc ctgcgaggcc gcgtcgcggc tggcgcgcgg     1080

cgaggatgag gcggagctgg cgctgagcct cctggcgcag ctgggcatca cgcctctgcc     1140

actcagccgc ggccccgtgc cagccaaacc caccgtgctc ttcgagaaga tgggcgtggg     1200

ccggctggac atgtatgtgc tgcacccgcc ctccgccggc gccgagcgca cgctggcctc     1260

tgtgtgcgcc ctgctggtgt ggcaccccgc cggccccggc gagaaggtgg tgcgcgtgct     1320

gttccccggt tgcaccccgc ccgcctgcct cctggacggc ctggtccgcc tgcagcactt     1380

gaggttcctg cgagagcccg tggtgacgcc ccaggacctg gaggggccgg ggcgagccga     1440

gagcaaagag agcgtgggct cccgggacag ctcgaagaga gagggcctcc tggccaccca     1500

ccctagacct ggccaggagc gccctggggt ggcccgcaag gagccagcac gggctgaggc     1560

cccacgcaag actgagaaag aagccaagac cccccgggag ttgaagaaag accccaaacc     1620

gagtgtctcc cggacccagc cgcgggaggt gcgccgggca gcctcttctg tgcccaacct     1680

caagaagacg aatgcccagg cggcacccaa gccccgcaaa gcgcccagca cgtcccactc     1740

tggcttcccg ccggtggcaa atggaccccg cagcccgccc agcctccgat gtggagaagc     1800

cagccccccc agtgcagcct gcggctctcc ggcctcccag ctggtggcca cgcccagcct     1860

ggagctgggg ccgatcccag ccggggagga gaaggcactg gagctgcctt tggccgccag     1920

ctcaatccca aggccacgca caccctcccc tgagtcccac cggagccccg cagagggcag     1980

cgagcggctg tcgctgagcc cactgcgggg cggggaggcc gggccagacg cctcacccac     2040

agtgaccaca cccacggtga ccacgccctc actacccgca gaggtgggct ccccgcactc     2100

gaccgaggtg gacgagtccc tgtcggtgtc ctttgagcag gtgctgccgc catccgcccc     2160

caccagtgag gctgggctga gcctcccgct gcgtggcccc cgggcgcggc gctcggcttc     2220

cccacacgat gtggacctgt gcctggtgtc accctgtgaa tttgagcatc gcaaggcggt     2280

gccaatggca ccggcacctg cgtcccccgg cagctcgaat gacagcagtg cccggtcaca     2340

ggaacgggca ggtgggctgg gggccgagga gacgccaccc acatcggtca gcgagtccct     2400

gcccaccctg tctgactcgg atcccgtgcc cctggccccc ggtgcggcag actcagacga     2460

agacacagag ggctttggag tccctcgcca cgaccctttg cctgaccccc tcaaggtccc     2520

cccaccactg cctgacccat ccagcatctg catggtggac cccgagatgc tgccccccaa     2580

gacagcacgg caaacggaga acgtcagccg cacccggaag cccctggccc gccccaactc     2640

acgcgctgcc gcccccaaag ccactccagt ggctgctgcc aaaaccaagg ggcttgctgg     2700

tggggaccgt gccagccgac cactcagtgc ccggagtgag cccagtgaga agggaggccg     2760

ggcacccctg tccagaaagt cctcaacccc caagactgcc actcgaggcc cgtcggggtc     2820

agccagcagc cggcccgggg tgtcagccac cccacccaag tccccggtct acctggacct     2880

ggcctacctg cccagcggga gcagcgccca cctggtggat gaggagttct tccagcgcgt     2940

gcgcgcgctc tgctacgtca tcagtggcca ggaccagcgc aaggaggaag gcatgcgggc     3000

cgtcctggac gcgctactgg ccagcaagca gcattgggac cgtgacctgc aggtgaccct     3060

gatccccact ttcgactcgg tggccatgca tacgtggtac gcagagacgc acgcccggca     3120

ccaggcgctg ggcatcacgg tgttgggcag caacagcatg gtgtccatgc aggatgacgc     3180

cttcccggcc tgcaaggtgg agttctagcc ccatcgccga cacgcccccc actcagccca     3240

gcccgcctgt ccctagattc agccacatca                                      3270


<210> 4420
<211> 2627
<212> DNA
<213> Homo sapiens

<400> 4420
attttggctg cctctgtcgg tctgttcagt taccacgtga accgccgacg gagacccgta       60

gtgggggagg cggcggcagc gttaagtgag aaaggattaa cattgaactg tttggggaaa      120

aaggaagaag cttatgaatt ggttcgtaga ggtttgagaa atgacttgaa gagtcatgtg      180

tgttggcacg tttatggcct tcttcagagg tcagacaaga agtatgatga agccattaag      240

tgttacagaa atgcactaaa atgggataaa gacaatcttc aaatcttaag ggacctttcc      300

ttactacaga ttcaaatgcg agatcttgag ggttacaggg aaacgaggta tcagttactt      360

cagcttcgac ctgcgcagag agcatcatgg attggttatg ctattgctta ccatttatta      420

gaagattatg aaatggcagc aaagatttta gaagaattta ggaaaacaca acagacatcc      480

cctgacaagg tggattatga atatagtgaa ctactcttat atcagaatca agttcttcgg      540

gaagcaggtc tctatagaga agctttggaa catctttgta cctatgaaaa gcagatttgt      600

gataaacttg ctgtagaaga aaccaaaggg gaacttctgt tgcaactatg tcgtttggaa      660

gatgctgcag atgtttatag aggattgcaa gagagaaatc ctgaaaactg ggcctattac      720

aaaggcttgg aaaaagcact caagccagct aatatgttag aacggctaaa aatttatgag      780

gaagcctgga ctaaatatcc caggggactg gtgccaagaa ggctgccgtt aaacttttta      840

tctggtgaga agtttaaaga atgtttggat aagttcctaa ggatgaattt cagcaagggt      900

tgcccaccag tcttcaatac tttaagatca ttatacaaag acaaagaaaa ggtggcaatc      960

atagaagagt tagtagtagg ttatgaaacc tctctaaaaa gctgccggtt atttaacccc     1020

aatgatgatg gaaaggagga accaccaacc acattacttt gggtccagta ctacttggca     1080

caacattatg acaaaattgg tcagccatct attgctttgg agtacataaa tactgctatt     1140

gaaagtacac ctacattaat agaactcttt ctcgtgaaag ctaaaatcta taagcatgct     1200

ggaaatatta aagaagctgc aaggtggatg gatgaggccc aggccttgga cacagcagac     1260

agatttatca actccaaatg tgcaaaatac atgctaaaag ccaacctgat taaagaagct     1320

gaagaaatgt gctcaaagtt tacaagggaa ggaacatcag cggtagagaa tttgaatgaa     1380

atgcagtgca tgtggttcca aacagaatgt gcccaggctt ataaagcaat gaataaattt     1440

ggtgaagcac ttaagaaatg tcatgagatt gagagacatt ttatagaaat cactgatgac     1500

cagtttgact ttcatacata ctgtatgagg aagattaccc ttagatcata tgtggactta     1560

ttaaaactag aagatgtact tcgacagcat ccattttact tcaaggcagc aagaattgct     1620

atagagatct atttgaagct tcatgacaac ccccttacag atgagaataa agaacacgaa     1680

gctgatacag caaacatgtc tgacaaagag ctaaagaagc tacgtaataa acaaagaaga     1740

gctcaaaaga aagcccagat agaagaagag aaaaaaaatg cagaaaaaga aaagcagcag     1800

agaaatcaga aaaagaagaa ggatgatgat gatgaggaga taggaggtcc aaaagaagaa     1860

cttattccag agaaactggc caaggttgaa actccattgg aagaagctat taaattttta     1920

acaccgttga agaacttggt gaagaacaag atagagactc atctttttgc ctttgagatt     1980

tactttagga aagaaaagtt tcttttgatg ctacaatcag taaagagggc atttgctatt     2040

gattctagtc atccctggct tcatgagtgt atgattcgtc tctttaatac tgcagtgtgt     2100

gaaagtaaag atttatctga tacagttaga acagtattaa aacaagaaat gaatcgtctt     2160

tttggagcaa cgaatccaaa gaattttaat gaaacttttc tgaaaaggaa ttctgattca     2220

ttgccacaca gattatcagc tgccaaaatg gtatattact tagatccttc tagtcagaag     2280

cgagctatag agttggcaac aacacttgat gaatctctca ctaacagaaa cctccagaca     2340

tgtatggagg tattggaagc cttgtatgat ggtagcctag gagactgtaa agaagctgct     2400

gaaatttata gagcaaattg tcataagctt ttcccttatg ctttggcttt catgcctcct     2460

ggatatgaag aggatatgaa gatcacagtt aatggagata gttctgcaga agctgaagaa     2520

ctggccaatg aaatttgaac atcactaaac aagcaaatgg aatgactttg gaccatatct     2580

agtatataat atttttgtca cgcacctgct gcattgctct aacttac                   2627


<210> 4421
<211> 582
<212> DNA
<213> Homo sapiens

<400> 4421
agcgccggtc ggaggcggtc ggcggaggtg tctaccccgc cggtgatggc gttgaacgcc       60

actggcttcc cggccttccg tccgctgcct ccgtccgatt ctgcgtctgc ttgctgagga      120

ggcggattag gggggcgcgg agtctcttcc cttgagtgca taggtcccgg ttggtagagg      180

gtttgagtcc gcatcgccac agctgaaggc tgcgagggac taagagcaga gaagatgcaa      240

gagttagaat tataatgcaa ctttatgtaa gaagcagaag ttcttccaag aagaggttga      300

gactttaatg tagcatgaca cattgaggcc acttcggctg gtcagcagtg tttgtgaaca      360

gtgtgtcaag tcacctgacc aagcagagat atatctttag aaatgagttg cacaattgag      420

aaggcacttg ccgacgctaa agctcttgtt gaaagattaa gagatcatga cgatgcagca      480

gaatctctga ttgagcaaac cacagctctc aacaagcgag tagaagccat gaaacagtat      540

caggaagaaa ttcaagaact taatgaagtc gcgagacatc gg                         582


<210> 4422
<211> 1558
<212> DNA
<213> Homo sapiens

<400> 4422
gcgctcgtgg ggaaaaggca gggagggggt ggtgtcccca gccggtttgg ggggtgcgtt       60

gcccggagac ggaaagtttg ggagcccgag caggctcggc tgcagcctcg gggagggggt      120

ccagcgggtg gcggccctgg ggatggggaa ggagcaggag ctgctggagg cggcccgcac      180

cgggcacctc ccggcggtgg agaagctgct gtccgggaag cggctctcct caggctttgg      240

gggcggcggc ggcggtggct ctgggggcgg cggcggcggc agcggcggcg gcggcggcgg      300

cctcggctct tccagccacc ccctctccag tctgctcagc atgtggagag ggccaaatgt      360

gaactgtgtt gacagcactg gctacacacc cctgcaccat gctgctttga atggccataa      420

ggatgtggtc gaggttcttc tgaggaacga tgcgctgacc aacgtggctg actcaaaagg      480

ctgctaccct ctgcatttgg cagcctggaa aggagatgcc cagatagtgc ggttgctcat      540

ccatcaaggg ccttcacaca ccagagtcaa tgaacagaac aatgacaacg agacagccct      600

gcattgtgca gcgcagtatg gccacacaga ggtggtgaag gtgctcttag aggagctgac      660

ggaccccacc atgcgcaaca acaaattcga gacccctttg gacctggcag cactgtacgg      720

gcgactggag gtggtgaaaa tgctccttaa tgcacacccc aacctcctga gctgcaacac      780

taagaagcac acccctctgc acttggcagc aaggaatggc cacaaagccg tggtccaggt      840

cctcctcgat gctggcatgg acagcaacta ccagacggag atgggcagtg ctttgcatga      900

ggctgctttg tttggcaaga ccgatgtggt gcaaatcctg ctggctgcag gaactgacgt      960

caacataaaa gataaccatg gactgactgc cctagacact gttcgggaac tgccttctca     1020

aaagagccag caaatagcag cattaattga agatcacatg actggaaaaa gaagtacaaa     1080

agaagtagat aaaacccccc caccccagcc acctctcatc tccagtatgg actccatatc     1140

acagaagtct cagggtgacg tggagaaagc agtgactgaa ctgattatag attttgatgc     1200

aaatgctgaa gaagagggtc cctacgaagc tctgtataat gccatctcct gccattcgtt     1260

ggacagcatg gccagcgggc gatcatctga ccaagactcc acgaacaagg aggctgaggc     1320

agcaggagtg aaacctgctg gagtgaggcc tagggaacgt ccaccacctc cagcaaagcc     1380

accgcccgat gaagaggaag aagaccacat agataagaag tattttccct tgacagcttc     1440

tgaggttctg tccatgagac ctaggattca tgggagtgca gcccgggaag aagacgaaca     1500

cccttatgaa ctgttgttaa cagcagagac aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1558


<210> 4423
<211> 3715
<212> DNA
<213> Homo sapiens

<400> 4423
gccgccgccg ccgccgccgc cgcgccgcgg cttgagggcg ggaggctggg ggagggtagc       60

ggagccggcg ccgccgccat gttgggtctg aagcggctgc tgtaggcgcc gacggagcga      120

gcgggcgtgc ggagcgggcg acagtggcgt gggatctgcc tctctgcgag cagctgggag      180

cggcggcggc ggcgccatga gcgggggcac cccttacatc ggcagcaaga tcagcctcat      240

ctccaaggcg gagatccgct acgagggcat cctctacacc atcgacaccg aaaactccac      300

cgtagccctt gccaaagttc gatcctttgg tacagaagac agaccgacag atcgtccaat      360

accacctcga gatgaagtct ttgaatacat tatattccgt gggagtgaca ttaaagacct      420

tactgtttgt gagccaccaa aaccacagtg ttctttgcct caagacccag ctattgttca      480

gtcctcacta ggctcatcga cttcttcatt ccagtccatg ggttcttatg gacctttcgg      540

caggatgccc acatacagtc agttcagtcc gagttcctta gttgggcagc agtttggtgc      600

tgttggtgtt gctggaagct ctttgacatc ctttggaaca gaaacatcaa acagtggtac      660

cttaccccaa agtagtgcgg ttggttctgc ctttacacag gatacaagat ctctaaaaac      720

acagttatct caaggtcgct caagccctca gttagaccct ttgagaaaaa gcccaaccat      780

ggaacaagca gtgcagaccg cctcagccca cttacctgct ccagcagctg ttgggagaag      840

gagtcctgta tcaaccaggc ctttgccatc tgccagccaa aaggcaggag agaatcagga      900

gcacaggcga gctgaagtac acaaagtttc aaggccagaa aatgagcaac tcagaaatga      960

taacaagaga caagtagctc caggtgctcc ttcagctcca aggagagggc gtgggggtca     1020

tcggggtggc aggggaagat ttggtattcg gcgagatggg ccaatgaaat ttgagaaaga     1080

ctttgacttt gaaagtgcaa atgcacaatt caacaaggaa gagattgaca gagagtttca     1140

taataaactt aaattaaaag aagataaact tgagaaacag gagaagcctg taaatggtga     1200

agataaagga gactcaggag ttgataccca aaacagtgaa ggaaatgccg atgaagaaga     1260

tccacttgga cctaattgct attatgacaa aactaaatcc ttctttgata atatttcttg     1320

tgatgacaat agagaacgga gaccaacctg ggctgaagaa agaagattaa atgctgaaac     1380

atttggaatc ccacttcgtc caaaccgtgg ccgtggggga tacagaggca gaggaggtct     1440

tggtttccgt ggtggcagag ggcgtggtgg tggcagaggt ggtaccttca ctgcccctcg     1500

aggatttcgc ggtggattca gaggaggtcg tgggggccgg gagtttgcgg attttgaata     1560

taggaaagac aacaaagttg ctgcatagtc tacaaacaag tctctgaaaa taggtgaatt     1620

tctagctctt catggtcctg aacattgatt tcagtctttg caaagaatga agaagtgaat     1680

tcgctgtaca tttgtcacca gcactgggtt tttgtttttt gtttgttttt ccgcttaatt     1740

tcaaagataa aatgcagtta cttttggggg tggaaggctc atcttaaaac atgagcatta     1800

aatatatttg gaatagcaga aggttaagta atttcttatg tatagttaaa ctaaagcagt     1860

acttcagtgg gacttaacaa gtattttttc atcactgaaa ggtttttttt ttttatcact     1920

aaattgtatt tggcaattgc aagttgcctg cagatagggc cgtgatactg tgttttgagc     1980

cacagaaggt tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtgtgtgtc     2040

tttttcctcc tttcttttgg ggaatcctgt aatatgaggt agcttatttc gtcaattaat     2100

tagggtgctg gatggtagag aattttgtca gtcaactatg tacacacagt aaatactgtt     2160

tcttaggcaa aggtaacttt tttatatagt tgtaaaattc cattatattc cattgccaaa     2220

gaaacattaa gaactttgta tagctgtata aaaagcaact aattttttaa agaataaaca     2280

ttttaaagtc agcaaacata ctgtgtcctt gcagaagttg atgtgctgag cagcagcctt     2340

atgggtgggt ctttttttct tagttttcca ggcttaacat ttttgatttt gttttttaat     2400

gtttggaaca taaatgaaga tttgatacat tatttcatta tctaaaaagg attaattatt     2460

catgctcatt gtaagaactt cattttgtag caaatggcat atcacaggat ctgtccagat     2520

aatcgatatt ttcagtatac aaatgtaaat aatcacagat gagaatgtac ttagctgtat     2580

tttcaaataa gtaatcttcc ccccttttgt aggactttaa aactaggcat caatgaacct     2640

gtttttccta ttatgcctgg aatttagtca tgataccttg actcattcca tcatatttca     2700

agaggattca gagtgctaga aattattttg gtagcctgta acacacggca acactggtcc     2760

ttgggcctat gatgacccac agatgactca gtatagagtt cattgctaat tataaattac     2820

tagtgaatct ttttgatatt ttaagctcta gtgggaaaaa tctggccact tttgtgtttt     2880

tatgaaggcc atggaataaa aggatccaaa gatttaaata tttttatcta atattttgat     2940

tgttttctta actttctcct taaaacattc agtagtgata aagatataga aactgcactg     3000

taggagaatt ggaatattta aggctggttg acatttttta ttttcatttt atatcttttg     3060

tatagctcta caaggcagtg ttttgtaatt tggtttcatt atgaagatcc agtacttggc     3120

agccatagtt tagacaatat tgttcagtgc tgtttgcttg catgttaaca acaaaacctt     3180

ttagaggacc cacaaatcat gatattgaac acagttccga ggcattcaga gcatcagagc     3240

aagtaccatg gcaatacatg tgtagactgt tggagatgtc ccgggccaat ttcaagaaag     3300

aaaactgtaa atactagttc tacttgctct gaaattatga gtttatgcgt tttcccagcc     3360

ctccgaatca ctgactgggg cgttttgtgc cccagcaata actggcagca tggcatacct     3420

gcagtacccc ttacaatatt aaagcaaagt ttttattcta aaacagaata aaactgttca     3480

ataaaaaatg ctcgtcaaag ttctttctct ttaaatagta acattctgtt tcagtaggaa     3540

cataatgaaa ggaatctttt aaatggaaga gcggaattat aatgtttgta ttccctgtaa     3600

taactataaa tcagttactt tatttctaag attgagttat tgttgcagat gtttagggaa     3660

agctaaaagc cccttccttc ccctcctgtg tgtaaataaa atacttctga gatca          3715


<210> 4424
<211> 2186
<212> DNA
<213> Homo sapiens

<400> 4424
gggccggagc cggagcccaa gccagagcgg cgcggcctgg aagaggccag ggcccggggg       60

aggcggcggc agcggcggcg gctggggcag cccgggcagc ccgagccccg cagcctgggc      120

ctgtgctcgg cgccatgagc ggcggcgggc cttcgggagg cggccctggg ggctcgggca      180

gggcgcggac tagctcgttc gcggagcccg gcggcggagg cggaggaggc ggcggcggcc      240

ccggaggctc ggcctccggc ccaggcggca ccggcggcgg aaaggcatct gtcggggcca      300

tgggtggggg cgtcggggcc tcgagctccg ggggtggacc cggcggcagc ggcggaggag      360

gcagcggagg ccccggcgca ggcactagct tcccgccgcc cggggtgaag ctgggccgtg      420

acagcgggaa ggtgaccaca gtcgtagcca ctctaggcca aggcccagag cgctcccaag      480

aagtggctta cacggacatc aaagtgattg gcaatggctc atttggggtc gtgtaccagg      540

cacggctggc agagaccagg gaactagtcg ccatcaagaa ggttctccag gacaagaggt      600

tcaagaaccg agagctgcag atcatgcgta agctggacca ctgcaatatt gtgaggctga      660

gatacttttt ctactccagt ggcgagaaga aagacgagct ttacctaaat ctggtgctgg      720

aatatgtgcc cgagacagtg taccgggtgg cccgccactt caccaaggcc aagttgacca      780

tccctatcct ctatgtcaag gtgtacatgt accagctctt ccgcagcttg gcctacatcc      840

actcccaggg cgtgtgtcac cgcgacatca agccccagaa cctgctggtg gaccctgaca      900

ctgctgtcct caagctctgc gattttggca gtgcaaagca gttggtccga ggggagccca      960

atgtctccta catctgttct cgctactacc gggccccaga gctcatcttt ggagccactg     1020

attacacctc atccatcgat gtttggtcag ctggctgtgt actggcagag ctcctcttgg     1080

gccagcccat cttccctggg gacagtgggg tggaccagct ggtggagatc atcaaggtgc     1140

tgggaacacc aacccgggaa caaatccgag agatgaaccc caactacacg gagttcaagt     1200

tccctcagat taaagctcac ccctggacaa aggtgttcaa atctcgaacg ccgccagagg     1260

ccatcgcgct ctgctctagc ctgctggagt acaccccatc ctcaaggctc tccccactag     1320

aggcctgtgc gcacagcttc tttgatgaac tgcgatgtct gggaacccag ctgcctaaca     1380

accgcccact tccccctctc ttcaacttca gtgctggtga actctccatc caaccgtctc     1440

tcaacgccat tcttatccct cctcacttga ggtccccagc gggcactacc accctcaccc     1500

cgtcctcaca agctttaact gagactccga ccagctcaga ctggcagtcg accgatgcca     1560

cacctaccct cactaactcc tcctgagggc cccaccaagc acccttccac ttccatctgg     1620

gagccccaag aggggctggg aaggggggcc atagcccatc aagctcctgc cctggctggg     1680

cccctagact agagggcaga ggtaaatgag tccctgtccc cacctccagt ccctccctca     1740

ccagcctcac ccctgtggtg ggctttttaa gaggatttta actggttgtg gggagggaag     1800

agaaggacag ggtgttgggg ggatgaggac ctcctacccc cttggccccc tcccctcccc     1860

cagacctcca cctcctccag accccctccc ctcctgtgtc ccttgtaaat agaaccagcc     1920

cagcccgtct cctcttccct tccctggccc ccgggtgtaa atagattgtt ataatttttt     1980

tcttaaagaa aacgtcgatt cgcaccgtcc aacctggccc cgcccctcct acagctgtaa     2040

ctcccctcct gtcctctgcc cccaaggtct actccctcct caccccaccc tggagggcca     2100

ggggagtgga gagagctcct gatgtcttag tttccacagt aaggtttgcc tgtgtacaga     2160

cctccgttca ataaattatt ggcatg                                          2186


<210> 4425
<211> 1093
<212> DNA
<213> Homo sapiens

<400> 4425
aatggagaag caaatggcaa ggatggttac cttggctacc aagataaaga accttgaaaa       60

gggaagaaga tgaaatcagc ttcggatatc aggcaggcag ctgggtctgt gggtcagagg      120

cttaaggatg gatgcagagc atccggaact caggagttac gctcagagcc aaggttggtg      180

gacgggagag ggcgagttca atttttccga agtcttttct ccagttgagg atcatctaga      240

ctgcggtgct ggcaaagaca gcttagaaaa acaagaagaa agcatcacag tgcagactat      300

gatgaacacc ttacgggaca aagccagcgg agtgtgcata gactctgagt ttttcctcac      360

cacagccagt ggagtgtctg tcctgccgca gaatagaagc tctccgtgca ttcactactt      420

cactggaacc cctgatcctt ccaggtccat attcaagcct ttcatctttg ttgatgacgt      480

aaaacttgtc cccaaaacac agtctccctg ttttggggat gacgaccctg ccaaaaagga      540

gcctcggttc caggagaaac cagaccgccg gcatgagctg tacaaagccc acgagtgggc      600

acgtgccatc atcgaaagtg accaggagca aggtcgcaag ctgaggagca ccatgctgga      660

gctggagaag caaggcctgg aagccatgga agaaatcctg accagctccg agccactgga      720

ccctgcggaa gtgggggacc ttttctatga ctgtgttgac acggagatta agttctttaa      780

gtgaagtaag cgttcccttt ccccttctta tttaagactt cccaccttac taaattacca      840

gcaaaacaaa ccactctcct gtttgagtaa aatgagaaag ttaatatgtg gcctcctttt      900

ctgaagccag atcaaactgt taccttgtgt tccaccttga atctcacagc gtccccttct      960

gcaatgtagg tctccttcct gtgcagtgta acatgtatcc cgttgcctgt tgttcggttg     1020

tgtgactaat tgtggatttt aagctgctat tattgtattt cagtggcaat ggacacatta     1080

gccttttaca aga                                                        1093


<210> 4426
<211> 914
<212> DNA
<213> Homo sapiens

<400> 4426
acgcccgcgg cgccggctgg ggcatcaccg cgggcctcga ccccgaaatg gcgctgctgg       60

ccgaacactt gctgaagccg ctgcccgcgg acaagcagat cgagaccggg cccttcctcg      120

aggcggtgtc ccacctgccg cccttcttcg attgccttgg gtccccagtg tttactccca      180

tcaaggcaga cataagcggc aacatcacga aaatcaaagc tgtgtacgac accaacccag      240

ccaagttccg gaccctgcag aacatcctgg aggtggagaa agaaataggc ctccgcttca      300

tccaggtctt cctccagagc atctgcgacg gggagcggga cgagaaccac cccaacctca      360

tccgtgtcaa cgccaccaag gcctacgaga tggccctcaa gaagtaccat ggctggatcg      420

tgcagaagat cttccaggca gcactgtacg cagcacccta taagtctgac ttcctgaaag      480

cgctctccaa ggggcagaat gttacggagg aggagtgcct ggagaagatc cgcctcttcc      540

tagtcaacta cacggcgacc atcgatgtca tctacgagat gtacacccag atgaacgctg      600

agcttaacta caaggtgtag gcatgcccac tgctggacac gtccccgact cgtggccaca      660

tggagaaaca ggcaaaccag aatcactgtg aatcaagtcg gtgaactgcc cctggcctgt      720

gtcccccaga gcagcccagg gtcctgccag agtctgcagg ggacagccct cgttttttaa      780

gtcttttttt tttttttttt tggtctattc taaaggacca gtaaataatg atcttacttc      840

caaatctcct tggaatttca cgacagcaca gactgacttt ataccttcat ttcagcgtgg      900

taaaaaccga ttaa                                                        914


<210> 4427
<211> 1391
<212> DNA
<213> Homo sapiens

<400> 4427
atgctcagta gctgaggtag ggatgccatc cttctcaaaa gacttattga cagtgccaaa       60

gctcggtact ggacacaacg agggacctgg gtctacgata acgcgctttt gctcctcctg      120

aagtgtcttt ggtccaacgt tgttccaggt ttgtcaccgt ttctctccgg ccggtcaggg      180

caagagccag acctgtgcaa cagacctgca gaccaaagct gaccgattgg cacagatgag      240

catatgttct tcattggccc ggaaattccc caaactcaca attatagggg aagaggatct      300

gccttctgag gaagtggatc aagagctgat tgaagacagt cagtgggaag aaatactgaa      360

gcaaccatgc ccatcgcagt acagtgctat taaagaagaa gatctcgtgg tctgggttga      420

tcctctggat ggaaccaagg aatataccga aggtcttctt gacaatgtaa cagttcttat      480

tggaattgct tatgaaggaa aagccatagc aggagttatt aaccagccat attacaacta      540

tgaggcagga ccagatgctg tgttggggag gacaatctgg ggagttttag gtttaggcgc      600

ctttgggttt cagctgaaag aagtccctgc tgggaaacac attatcacaa ctactcgatc      660

ccatagcaac aagttggtta ctgactgtgt tgctgctatg aaccccgatg ctgtgctgcg      720

agtaggagga gcaggaaata agattattca gctgattgaa ggcaaagcct ctgcttatgt      780

atttgcaagt cctggttgta agaagtggga tacttgtgct ccagaagtta ttttacatgc      840

tgtgggaggc aagttaaccg atatccatgg gaatgttctt cagtaccaca aggatgtgaa      900

gcatatgaac tctgcaggag tcctggccac actgaggaat tatgactact atgcaagccg      960

agttccagaa tctattaaaa atgcacttgt tccttaaagg aaagtttcat ttggccgggc     1020

gcggtggctc atgcctgtaa tcccagcact ttgggaggcc gaggcaggtg gatcacttga     1080

gctcaggagt ttgagaccag cctgggcaat atcgtgagac cccatctcta caaaaataca     1140

aattaactgg gcatcctgtc atgcgcctgt catcccagct acttgagagg ctgaagcaga     1200

agaatctctt gagcccggaa ggcagaggtt gcagtgagct gagatcgtgc cactgcactc     1260

cagcctgagt gacaggagtt aagccctgtc tcagaaaaaa aaaaaacaaa aacccaaaaa     1320

gtacttaaag tttcatttac ttagctagga gaaagacttg gttctcaaaa taatacattt     1380

taagattaat t                                                          1391


<210> 4428
<211> 1988
<212> DNA
<213> Homo sapiens

<400> 4428
atgggtgcct acctctccca gcccaacacg gtgaagtgct ccggggacgg ggtcggcgtc       60

tccatggagg atgctcacaa ctgtattcct gagctggaca gtgagacagc catgttttct      120

gtctacgatg gacatggagg ggaggaagtt gccttgtact gtgccaaata tcttcctgat      180

atcatcaaag atcagaaggc ctacaaggaa ggcaagctac agaaggcttt agaagatgcc      240

ttcttggcta ttgacgccaa attgaccact gaagaagtca ttaaagagct ggcacagatt      300

gcagggcgac ccactgagga tgaagatgaa aaagaaaaag tagctgatga agatgatgtg      360

gacaatgagg aggctgcact gctgcatgaa gaggctacca tgactattga agagctgctg      420

acacgctacg ggcagaactg tcacaagggc cctccccaca gcaaatctgg aggtgggaca      480

ggcgaggaac cagggtccca gggcctcaat ggggaggcag gacctgagga ctcaactagg      540

gaaactcctt cacaagaaaa tggccccaca gccaaggcct acacaggctt ttcctccaac      600

tcggaacgtg ggactgaggc aggccaagtt ggtgagcctg gcattcccac tggtgaggct      660

gggccttcct gctcttcagc ctctgacaag ctgcctcgag ttgctaagtc caagttcttt      720

gaggacagtg aggatgagtc agatgaggcg gaggaagaag aggaagacag tgaggaatgc      780

agcgaggaag aggatggcta cagcagtgag gaggcagaga atgaggaaga tgaggatgac      840

accgaggagg ctgaagagga cgatgaagaa gaagaagaag agatgatggt gccagggatg      900

gaaggcaaag aggagcctgg ctctgacagt ggtacaacag cggtggtggc cctgatacga      960

gggaagcagt tgattgtagc caacgcagga gactctcgct gtgtggtatc tgaggctggc     1020

aaagctttag acatgtccta tgatcacaaa ccagaggatg aagtagaact agcacgcatc     1080

aagaatgctg gtggcaaggt caccatggat gggcgagtca acgggggcct caacctctcc     1140

agagccattg gggaccactt ctataagaga aacaagaacc tgccacctga ggaacagatg     1200

atttcagccc ttcctgacat caaggtgctg actctcactg acgaccatga attcatggtc     1260

attgcctgtg atggcatctg gaatgtgatg agcagccagg aagttgtaga tttcattcaa     1320

tcaaagatca gccagcgtga tgaaaatggg gagcttcggt tattgtcatc cattgtggaa     1380

gagctgctgg atcagtgcct ggcaccagac acttctgggg atggtacagg gtgtgacaac     1440

atgacctgca tcatcatttg cttcaagccc cgaaacacag cagagctcca gccagagagt     1500

ggcaagcgaa aactagagga ggtgctctct actgaggggg ctgaagaaaa tggcaacagc     1560

gacaagaaga agaaggccaa gcgagactag cagtcatcca gacccctgcc cacctagact     1620

gttttctgag ccctccggac ctgagactga gttttgtctt tttcctttag ccttagcagt     1680

gggtatgagg tgtgcagggg gagctgggtg gcttcactcc gcccattcca aagagggctc     1740

tccctccaca ctgcagccgg gagcctctgc tgtccttccc agccgcctct gctcctcggg     1800

ctcatcaccg gttctgtgcc tgtgctctgt tgtgttggag ggaaggactg gcggttctgg     1860

tttttactct gtgaacttta tttaaggaca ttctttttta ttggcggctc catggccctc     1920

ggccgcttgc acccgctctc tgttgtacac tttcaatcaa cactttttca gactaaaggc     1980

caaaacct                                                              1988


<210> 4429
<211> 2634
<212> DNA
<213> Homo sapiens

<400> 4429
gactcccggg tccccgcgcc ggactgggac tgggagcagg cagcccgggc ggagcgggcc       60

ggtgccgagg acggccccag gcattgctct gccccgggca ttgcgcggcg cgcgtgaggg      120

ggatgcggca ggaggcggcg cggcgggagg agtaggcggc ggcgccctcg ggagggagct      180

gcgcgcgggc cagacggcgc ccggaggctc cgcagtgccg ccgccgtcgc ccgggaggct      240

ccgcgcggga gccatgtaac cctgcggcgg gctccgggct gctccgtcct tccccagctc      300

ccgggctagc gcggcagcgg ggccacgatg aagaagcagt tcaatcgcat gcgccagctg      360

gccaaccaga cggtgggcag ggctgaaaag acagaagttt tgagtgaaga ccttcttcag      420

gtggagaagc gtctggagct ggtgaaacag gtgtcccaca gcacgcacaa gaagctcacc      480

gcatgtctgc agggccagca aggggcagag gctgacaagc gctccaaaaa gttgcctttg      540

acaacactgg ctcagtgtct gatggagggg tcagctatcc tgggagatga cacacttctt      600

gggaagatgc tgaaactctg tggagagacg gaggacaagc tggctcagga gctgatacat      660

tttgagttgc aagtagagag agacgtgatt gagcccctgt ttttgctggc ggaggtggaa      720

atcccaaata ttcaaaagca gaggaaacac ttagccaagt tggtgctgga catggattcc      780

tcacgaacca ggtggcagca gacttccaag tcttcaggtt tgtccagcag cttacagcct      840

gcgggtgcca aggctgatgc cctcagggaa gaaatggaag aggctgccaa cagagtggag      900

atttgcaggg accagctctc agctgatatg tacagttttg tggccaaaga aattgactat      960

gcaaactact ttcaaacgct aatagaagtg caagctgaat accacaggaa gtccctgaca     1020

ctattgcagg ctgtattgcc tcagatcaaa gcacaacagg aggcctgggt agagaagcct     1080

tccttcggga agccgctgga ggagcacctc accatcagcg gccgggagat cgccttcccc     1140

atcgaggcgt gtgtgaccat gctgcttgag tgtgggatgc aggaggaggg actcttccga     1200

gtagccccct ctgcctccaa actgaagaag ctgaaagcgg ccctggactg ctgcgtggtg     1260

gatgtgcagg agtactcggc agacccccac gcaattgcag gagctttgaa atcttacctc     1320

cgagagttgc cagaacctct tatgaccttt gaactctatg atgagtggat ccaggcttcc     1380

aatgtccagg agcaagacaa gaagcttcag gctctatgga atgcttgtga aaagttgccc     1440

aaggccaatc acaacaacat ccgatacttg ataaaatttt tatccaagct gtcagaatat     1500

caagatgtaa acaagatgac tcccagtaat atggcaattg ttttaggacc caacctccta     1560

tggccacaag cagaagggaa cattacagag atgatgacca cagtgtcgct gcaaattgtt     1620

gggatcattg aacctatcat ccagcatgca gactggttct tccctgggga gatagagttc     1680

aacattactg gcaattatgg gagtccagta cacgtgaacc ataatgccaa ctacagctca     1740

atgccctccc cagacatgga ccctgctgac cggcgccagc ccgagcaggc ccgccggccc     1800

ctcagcgtcg ccacggataa tatgatgctg gagttttaca aaaaggatgg catgggtgtg     1860

agggtcatgg acacaaactg ggtggctcga agaggctcct cggccggtcg gaaagtgtcc     1920

tgcgccccgc cctccatgca gcctcccgcc ccgcccgccg agctggctgc gcccctgcct     1980

tcgccgctgc cggagcagcc cctggacagc cccgcggccc ccgcgctctc tccatccggc     2040

ctgggcctcc agcctgggcc cgagcgcacc agcacaacaa aaagcaagga actttctcca     2100

ggctctgcac agaaaggaag tccaggctcc agccagggca cagcctgtgc agggactcaa     2160

ccaggggctc aacctggagc tcagccgggc gccagcccca gccccagcca gccgcctgca     2220

gaccagagtc ctcacaccct ccggaaagtt tcaaagaagc tggcaccgat tccacccaag     2280

gtcccctttg gccagccggg ggctatggca gaccagtccg ctggccagcc gtccccagtc     2340

agcctgtccc ccaccccgcc cagcaccccg tcaccctatg gactgagcta ccctcagggg     2400

tactccttgg cctcgggcca gctctcccca gctgcagctc ctcccctggc ctctccttct     2460

gtctttacaa gcactttgag caaatcgcgg cccactccta agccgcgaca gagacctact     2520

ctgccgcctc ctcagcctcc cacagtaaac ctctcggcct ctagtccaca gtccacggag     2580

gcccccatgc tagatggcat gtcccctggg gaaagcatgt ctacagctgt gtga           2634


<210> 4430
<211> 3681
<212> DNA
<213> Homo sapiens

<400> 4430
tctcccggcc ttgttgactt tggcgtccgc ggggagctgc ccctgtgccc gtggttctct       60

gcgcatgccc ggaccccggc ggctccggag tccgggaggc tctggctgct ccagtcgcgg      120

gtccgggccc cgcctctcca ctcggcggtg gcgtccgtgt tgttattgtg gtggtagcgg      180

cgtctggctg ctgcggaccc cgccgagtcc tagcgcctgg cctgcgcgcc gctgcccgcg      240

ccacagattt gagttctgtg aacctgcatt tgttgttggt aattgcctcc agatagcttc      300

tgacagtcat cagtatgatc gaatttattg tggagctgga gtgcagaaag accatgaaaa      360

ctacatgaaa atattactaa aagttggagg catattagtc atgcctatag aggatcagtt      420

aacacagatt atgcgaactg gacagaacac ttgggaaagt aaaaatatcc ttgctgtttc      480

atttgctcca cttgtgcaac caagtaagaa tgataatggc aaaccagatt ctgtgggact      540

ccctccctgt gctgtcagga atctacagga cttggctcgt atttacattc gacgcacact      600

tagaaatttc ataaatgatg agatgcaggc caaggggatt cctcaaaggg ctccacccaa      660

aaggaaaaga aagagagtta aacagagaat taacacttac gtatttgtgg gtaatcagct      720

tattcctcag cctctagaca gtgaagagga tgaaaaaatg gaagaggata acaaagaaga      780

ggaggaaaaa gatcacaatg aagcaatgaa gccagaggag ccacctcaaa atttactgag      840

agaaaaaatc atgaagctgc ccctccctga atctttaaaa gcttacttga catattttag      900

agacaaataa cttagatcaa gaagaaaaat gcctactgat aattccttta gtcttgaaaa      960

tgtagcattt gttaggagtt aaaagagaga attatttctt tcatcagagc aaattatagt     1020

ggaaaaaaaa tcacttgttt ctgtcagtaa cacaaatgat gtattcagtg aataaaagaa     1080

tcccttttat aaaatctatt tttctttaaa tcttggaaaa atgttgtttt agctcagagt     1140

gatttcaaag tggaatgcaa cagtagtcaa gacttgtgta ctataaatcc ttttctgatt     1200

ccttacagat ttgtagtgat gaggtttaga tttaatttta tatatggttt aaataattgt     1260

taagcttata taacctgatc tgaattgcag ttgtttgcat ttcctctatg aaaacttcat     1320

ttatctaata aggaagtcaa atgctttgta gactatttac cttacttttg ttgcaatcac     1380

tgttgttggg ttgctgtata tatattccgg gcaatatatg agtgcaataa caatacaaga     1440

tattgaataa tttagcttta aaaaatccca caaattttat gaaattttac agccctgcta     1500

cttttgcttt tgaatctctt gccaaaagac atgggtaaaa tatctgcctc tctcatagag     1560

attttaagag cacagcaagt gaattattaa aacaaagtct atacttaata caactcttta     1620

tatggaccct ttacattttc agtatttaaa aaaatgaggt tatcttaact ctatagaatt     1680

ttaaaagtat atttagaatt gttttttctg tagttcactg tataaagtat ttggtttttt     1740

aaaaaaagca aaaccattgt tatgtgtgac tcttgatagg acacagaacg agtgaatgag     1800

catgagtgag gccactttct tggatggctg taagtagcag ggccagggta gacctggtca     1860

gcggatgcac tttagcagat ggaacttcta gtttatctga atatttatct ttgacaaggt     1920

agggctgagc ctacatttgc ttttgatcta tctagtataa gaaatattca cagaaattgt     1980

atgtagatac cctttgtttt gaaaatgctg ttcagaatca tagtgtaatc tttgggacct     2040

atgccatgtt catttcactc cttcccatat tttttgtgtt tcttttggta aaactataat     2100

ggttttcatt ttttacttaa tatcacacag ttaaactgtc catatttgag ctttatttta     2160

gcttatcagt gataaaaaac aggtagtaac tgccattgtt tgtttgtttt cctaataagg     2220

cctgaaaaca gccattcctt gttaagaaag tgtacaatgt aacatatttg ctagagttac     2280

atggattata tatttcttaa agggaaaaat ttgagagtat catggactac caccagcatt     2340

attattacag tagttactca gatttggtta aggaagccca agcaatgtat agtgaaagga     2400

ttattatctc tctgctaaga ttcagatatt gtttcagaaa tctcagctcc agtaattcca     2460

caacatctaa aaacaaatgt ttgtgatcat gtgtaagcat gaaattgttc caagtaagtg     2520

aggatatttt agttatgtga aagacagttt catggaaggt atttgtttta taccagtggc     2580

tgggatggtg gaattggggt tatttctaca attattctta gacgattact aaactgttaa     2640

gaaatgcccc atatcatttt tgtatctagg aaagaaaaaa atcagtttca tactgttgtc     2700

atctgtcaga aatgctcatt ttattttgaa ttaaatgtgg cttttgaagt acctagttac     2760

cttgaattcc tggtgaccac atgtttttat ctggaaaacc tggagaaagt tatctgtccc     2820

atctcccctg cttgtttttt tttttttttt tggttggagc tgctgtttag atgatgcttt     2880

tactatgcag gagagagttt ttgttaagga tatatttgaa gattggcttt tccatattgt     2940

ccttcattct ttgaccatgg caaagtgtac agtagatttt catgatcatt gcatatttct     3000

tgtcattgaa atgtatcttt tatgttttta aatgcattca ttttacactt gtgagtttat     3060

cattgacttt aagaggtaga aatgaaaaat gaaaattaaa gctaaagcct ttttatctat     3120

taatgcagat atattagaat aagaatattt tgggtttgtg tttatttttt aatgaattta     3180

tgtttacttg atatggaaaa ttacgcttta taggtggaaa agtagcaaat aaagattaag     3240

taaaagtaag tgaaaatgat ggggaatata gtattggaat tttatagcta gttaaaacag     3300

taagtatcat ctaatttggg tgtttatttt gcagatgaga aaacagacct agaaccgtgg     3360

catgttttgc ctgaaacata cagtgagtta gagacagggc ctaagatagc ttctagcatc     3420

agatcaatcc caagaatcca tcagcaacct cagaccaacc caagaagata atttaaatct     3480

atactgctta ttggtcaata tatttggttc tagtattaat aaagaaaaat gttattaaaa     3540

tagcatacat agtagtaaaa taaaatacaa aaagtgtgtt gatttatagc tgtttgagat     3600

gataaaagtg aagcaaagcc tgttaaatca ttggaagact tggaaaatta ttttaaataa     3660

acaattacat gtaattaagc a                                               3681


<210> 4431
<211> 3770
<212> DNA
<213> Homo sapiens

<400> 4431
gagagggagc cttgctctgt tgtccaggct ggagtgcagt ggcataatct cagctcactg       60

caacccctat ctcccaggtt caagcctcag ccttctgcat agctgggact acaggcatgc      120

accaccacac ccagctagtt tttgtatttt ttagtagaga cagagtttca ctatatgttg      180

gccaggctgg tctcgaactc ctgacctcag ctgatccacc tgcctcggcc tcccagagtg      240

ctgggattac agacgtaagc caccatgccc ggctggaatc attcatttct tttcaagtgg      300

gtatcttatg gtattttagg gcatggctgg gagcagtttt gttttctctt ctcaagactg      360

agtgtttgca ggatgtcata gagttcatgt ctgcagctca cagtgtcatt gcctgtgtcc      420

ccagctccac gtactggcag gtgtgctgca agctgggtag gtgccctgtg tccctgggat      480

accttaaccg acactcctgg ccctcctctg caagctgtgc cctgatcctc cctgcaggga      540

ctggggattg ggtctgctca cctagaagcc aggatacctg gctgagggca cttctctccc      600

tcttctcttt gaacagagtg gccacaaact caaaggtgcg ggagcaagtg cggctggagc      660

tgagcttcgt caactcagac ctgcagatgc tcaaggaaga gctggagggg ctgaacatct      720

cggtgggcgt ctatcagaac acagaggagg catttacgat tcccctgatt cctcttggcc      780

tgaaggaaac gaaagacgtc gactttgcag tcgtcctcaa ggattttatc ctggaacatt      840

acagtgaaga tggctattta tatgaagatg aaattgcaga tcttatggat ctgagacaag      900

tatgactctc tcaccggggt tccggtcagc cagcagaacc tgctgctgga gaaggccagt      960

gtcctgttca acactggggc cctctacacc cagattggga cccggtgtga tcggcagacg     1020

caggctgggc tggagagtgc catagatgcc tttcagagag ccgcaggggt tttaaattac     1080

ctgaaagaca catttaccca tactccaagt tacgacatga gccctgccat gctcagcgtg     1140

ctcgtcaaaa tgatgcttgc acaagcccaa gaaagcgtgt ttgagaaaat cagccttcct     1200

gggatccgga atgaattctt catgctggtg aaggtggctc aggaggctgc taaggtggga     1260

gaggtctacc aacagctaca cgcagccatg agccaggcgc cggtgaaaga gaacatcccc     1320

tactcctggg ccagcttagc ctgcgtgaag gcccaccact acgcggccct ggcccactac     1380

ttcactgcca tcctcctcat cgaccaccag gtgaagccag gcacggatct ggaccaccag     1440

gagaagtgcc tgtcccagct ctacgaccac atgccagagg ggctgacacc cttggccaca     1500

ctgaagaatg atcagcagcg ccgacagctg gggaagtccc acttgcgcag agccatggct     1560

catcacgagg agtcggtgcg ggaggccagc ctctgcaaga agctgcggag cattgaggtg     1620

ctacagaagg tgctgtgtgc cgcacaggaa cgctcccggc tcacgtacgc ccagcaccag     1680

gaggaggatg acctgctgaa cctgatcgac gcccccagtg ttgttgctaa aactgagcaa     1740

gaggttgaca ttatattgcc ccagttctcc aagctgacag tcacggactt cttccagaag     1800

ctgggcccct tatctgtgtt ttcggctaac aagcggtgga cgcctcctcg aagcatccgc     1860

ttcactgcag aagaagggga cttggggttc accttgagag ggaacgcccc cgttcaggtt     1920

cacttcctgg atccttactg ctctgcctcg gtggcaggag cccgggaagg agattatatt     1980

gtctccattc agcttgtgga ttgtaagtgg ctgacgctga gtgaggttat gaagctgctg     2040

aagagctttg gcgaggacga gatcgagatg aaagtcgtga gcctcctgga ctccacatca     2100

tccatgcata ataagagtgc cacatactcc gtgggaatgc agaaaacgta ctccatgatc     2160

tgcttagcca ttgatgatga cgacaaaact gataaaacca agaaaatctc caagaagctt     2220

tccttcctga gttggggcac caacaagaac agacagaagt cagccagcac cttgtgcctc     2280

ccatcggtcg gggctgcacg gcctcaggtc aagaagaagc tgccctcccc tttcagcctt     2340

ctcaactcag acagttcttg gtactaatgt gaggaaacaa acatgttcag gccctgaaca     2400

tttccggtgc tgactcggcc ttaaacgttt gtgccataat ggaaaatatc tatctatctg     2460

ttctcaaatc ctgtttttct catagtgtaa actcacattt gatgtgtttt tatgaaggaa     2520

agtaaccaag aaacctctag gaattagtga aaaaagaact tttttgaggt gtgttactat     2580

actgctgtaa gttatttatt atataaagta ttgtaaatag aatagtgttg aagatatgaa     2640

atatggctat ttttaatggt gacaattatg acttttagtc actattaaat tggggttacc     2700

tatatcagta caatttgtag ttgtttccag gtttggctaa taatcattcc ttaacctaga     2760

attcagatga tcctggaatt aaggcaggtc agaggactgt aatgatagaa ttaaattagt     2820

gtcactaaaa actgtcccaa agtgctgctt cctaatagga attcattaac ctaaaacaag     2880

atgttactat tatatcgata gactatgaat gctatttcta gaaaaagtct agtgccaaat     2940

ttgtcttatt aaataaaaac aatgtaggag cagcttttct tctagtttga tgtcatttaa     3000

gaattactaa cacagtggca gtgttagatg aagatgctgt ctacaaggta gataatatac     3060

tgtttgatac tcaaaacatt tttcattttg tttaaagtag aagttacata attctatatt     3120

ttaagtcttg ggtaaaaaag tagttttaca ttttataaag taaagatgta aatgattcag     3180

gtttaaagct ctatttgact tccttttttt gtttgagata gcgtcttgct gtgttgccca     3240

ggctggagtg cagtggtgtg atctcagctc agtgcaacct ccgccccctg ggatcaagcg     3300

attctcctac ctcagcctcc caaatagctg ggactacaag gtgccctcca gcatgcctgg     3360

ctgatttttg tatttttagt tgaggtgagg tttcaccatg ttggccaggc gggtttcgaa     3420

atcctgacct caaatgatcc acccacctca gcctcccaaa gtgctgggat tacaggcatg     3480

agccaccaca accgtcccac tattttactt tttaaaatga cattcctact gattgatttt     3540

tatcttgcta taagttcgat gacaccgtga atctaataag gttcactgtt gacacagtac     3600

aagttacata gctaaaatac atagcattga agactaattt taaggattga caagagttta     3660

ttttctattg tgcaatatct taaaggaagc aaccaccttt gggaaagtgt atctgctgct     3720

cctagggcca tgcttgtata catatttaaa taaacatatt catttacccg                3770


<210> 4432
<211> 8887
<212> DNA
<213> Homo sapiens

<400> 4432
aggtaaatgc gtgcccggaa gcgcgacctc gggcggttgg aggggctacc gggtcttacc       60

agtccgtggc gggagtcccg gaggaccctc gacgggggag ttgccgagaa aaggcctcgc      120

cggcattctt cccctccact gggtcctttg aacctagttt ggctgggact cgccttcagg      180

cggcgcggag gatttcgagg ccctgaggcg cggcccttaa tttccggaag tgggggccgc      240

gccgcgccgt caagatgtgc tcgacgcccg gaatgccggc gccgggggcc tcgctggccc      300

tgcgggtgtc cttcgtggac gtgcatcccg atgtgatccc ggtgcagctg tgggggctgg      360

tgggcgagcg gcggggcgag tacctgcggc tgagccggga aatccaggaa gcggcggcca      420

cgcgcggcca gtgggcgctg ggcagcgcct cggcctcgcc cggcgagctg tgcctggtgc      480

aggtcgggct tttgtggcac cgctgccgcg tggtcagccg gcaggcacag gagagccgtg      540

tcttcctgct ggacgagggc cgcaccatca cggccggagc aggctcgctg gcgcctgggc      600

gcagagagtt cttcaatttg ccctcggaag tgctgggctg cgtgctagcg ggcctggtgc      660

cggcaggctg cggcgcgggc tcaggcgagc cgccgcagca ctggcccgcc gacgccgtgg      720

acttccttag caaccttcag ggcaaggagg tgcacgggtg cgtcctggac gtgctgctgc      780

tccatcgcct ggtcctcctg gaggtgcctg atgtgttcca acagatgcgg gagctgggcc      840

tggctcggcg ggtgcccgac agcctcttcc gttcgctgct ggagcgctat ctcacagcgg      900

ccactgctag cgtgggctcc ggggtcccgg ttctctcgcg agtcccgctc aagcaaaagc      960

agcctggtct ggattacttc tatccccagc tgcagctggg cgtgacggag gccgtggtca     1020

taacccaagt gtgccatccc caccgcattc actgccagct ccgcagcgtc tcgcaggaga     1080

tccaccgcct ctccgagagc atggcccagg tataccgggg ttccacgggg acaggggatg     1140

agaactctac cagtgccacc tgggaggaga gggaggagag cccagataag ccgggctctc     1200

cgtgtgcatc ctgtggcctg gatggacatt ggtacagagc actgttgctt gagacttttc     1260

ggccccagcg ctgtgcccag gtgcttcatg tggactatgg aaggaaggag ttagtgagtt     1320

gcagcagcct tcggtacttg ctgcctgaat attttcgaat gccggtggtg acctaccctt     1380

gtgctttgta tggactctgg gacggtggga gaggctggtc tcggtcacag gtcggtgacc     1440

tgaagacact gatactaggc aaggcagtga atgcaaagat tgaattttat tgctcctttg     1500

agcatgtgta ttatgtcagc ctgtatggag aagatgggat taatctgaac cgtgtgtttg     1560

gagtacagtc gtgttgcttg gctgaccgag tccttcagag ccaggcaaca gaggaggagg     1620

aaccagaaac atctcagtct cagtctcctg ctgaagaagt agatgaagag atttcactcc     1680

cagccttaag atctatcagg ttaaagatga atgccttcta cgatgcgcag gtagagtttg     1740

ttaaaaatcc ttctgagttt tggattaggt tgaggaaaca caatgtcacc ttcagtaagc     1800

tgatgaggag aatgtgtggt ttctattcct ctgccagtaa gctggatggt gtagttttga     1860

aacctgaacc tgatgacctt tgctgtgtca agtggaaaga aaatggttat tatagggcca     1920

tagtcaccaa attggatgac aagagtgtgg atgtattctt agttgaccga ggcaattcgg     1980

aaaatgtgga ctggtatgac gtaaggatgc tgcttcctca gtttaggcag ctaccaatat     2040

tggctgtgaa gtgcaccctg gctgatattt ggcctttggg aaaaacttgg agccaggagg     2100

cagtttcctt ttttaaaaag actgtgctcc acaaagaatt agtcatccat attcttgata     2160

aacaggatca tcaatatgtt attgagattc ttgacgaatc aagaacaggg gaagaaaaca     2220

ttagtaaggt aattgcccaa gctggatatg ccaagtatca ggaatttgaa acaaaggaaa     2280

atatcctggt aaatgcccac tccccagggc atgtttcaaa ccactttact acggagagta     2340

acaaaatacc ttttgccaag actggagaag gagagcagaa agccaagaga gagaataaaa     2400

ccacatctgt ttcaaaagct ttgagtgaca caacagttgt aacaaatggt tcaactgaac     2460

tagttgtgca ggaaaaagtg aaaagagcat ctgtttattt tcctcttatg cagaattgct     2520

tggaaattaa gccaggctcc tctagtaaag gagagctgga agttggaagt acagtagaag     2580

tcagagtgtc ttatgttgaa aaccctggct atttctggtg tcagctgacc aggaacatac     2640

aaggacttaa aactctaatg tctgatattc agtactattg caaaaataca gctgctcctc     2700

accagagaaa cacccttgct tgtttggcta agcgaacagt aaacagacag tggtccagag     2760

cacttattag tgggatacag tctgtggagc atgtcaatgt aacatttgta gattatggag     2820

acagagaaat ggtatctgtg aagaatattt attcaattag tgaagaattt ctgaaggtta     2880

aggcacaggc ttttaggtgc agtctttata atttaattca accagttggc cagaatccct     2940

ttgtttggga tgtaaaggca atacaagctt tcaatgaatt tatagataat gcatggcaaa     3000

aaaatctaga attaaaatgt acaatatttg ctctggcttc aattaatgaa gaactgttta     3060

acattgtgga tttgctaacc ccctttcaga gtgcatgcca tttcttggta gaaaagagac     3120

ttgcaagacc agtaaaactt cagaagcctt tggagtcctc tgttcagcta cattcctact     3180

tctattctac acatgatatg aaaattggaa gtgaagaatt agtttatata acgcatattg     3240

atgacccttg gacattttat tgccagctgg caagaaatgc aaatatttta gaacagttgt     3300

catgtagtat tacacaatta agtaaagttt tgctgaattt aaaaacatct cccttgaacc     3360

ctggaacctt gtgccttgcc aagtatactg atggaaactg gtataggggc atagtaatag     3420

agaaagagcc aaagaaagtc ttctttgttg attttgggaa tatttatgta gtaacaagtg     3480

atgatctgct tccaatacct agtgatgcat atgatgtctt acttttgccc atgcaagctg     3540

tcagatgttc attatctgat attcctgatc atataccaga agaagtggtg gtgtggtttc     3600

aggagactat tttagataag tcattgaagg ctttagttgt agcaaaagat ccagatggaa     3660

cactgattat agaactatat ggtgacaata ttcaaattag tgctagtatt aataagaagt     3720

tggggctact tagttacaaa gatagaataa gaaaaaaaga aagtgaagtc ctctgttcta     3780

caactgaaac tcttgaagaa aaaaatgaga atatgaagtt gccatgtaca gagtatttaa     3840

gtaaatcagt agggtacaag ttacctaata aagaaatttt ggaagagtca tataaacctc     3900

agatcaactc atcatacaag gaactcaaac ttttacaaag tttaacaaaa acaaacttag     3960

tcactcaata tcaagactct gtgggaaata aaaatagtca agtgtttcca ttaacaacag     4020

aaaagaaaga agaaatttct gctgagacac ccttgaaaac agcaagagta gaagctactc     4080

tttcagagag aaaaatagga gattcatgtg acaaagattt gcctctgaaa ttttgtgagt     4140

tcccacagaa gactataatg cctggattta aaacaactgt atatgtttct catataaatg     4200

acctttcaga cttttatgtt caactaatag aagatgaagc tgaaattagt catctttcag     4260

agagattaaa cagtgttaaa acaaggcccg aatattatgt aggtccacct ttgcaaagag     4320

gagatatgat atgtgctgtt ttcccagaag ataatttatg gtatcgtgct gtgatcaagg     4380

agcaacaacc caatgacctt ctctctgtgc agtttataga ttatggcaat gtttctgtgg     4440

ttcatactaa caaaataggt aggcttgacc ttgttaatgc aatattgccg gggttgtgca     4500

ttcattgctc cttgcaggga tttgaggttc ctgacaataa aaattctaag aaaatgatgc     4560

attacttttc ccaacggacc agcgaggctg caataagatg tgaatttgtt aaatttcaag     4620

acagatggga agttattctt gctgatgaac atgggatcat agcagatgat atgattagca     4680

ggtatgctct cagtgaaaaa tctcaagtag aactttctac ccaagtaatt aaaagtgcca     4740

gttcaaagtc tgttaacaaa tcagacattg acacttcagt atttcttaac tggtataatc     4800

cagaaaaaaa aatgataaga gcttatgcca ctgtgataga tggacctgag tacttttggt     4860

gtcagtttgc tgatacggag aaacttcagt gtttagaagt agaagtacag actgctggag     4920

aacaggtagc agacaggaga aattgtatcc catgtcctta tattggagat ccttgtatag     4980

taagatacag agaagatgga cattattata gggcacttat cactaatatt tgtgaagatt     5040

atcttgtatc tgtcaggctt gtggactttg gaaacattga agactgtgtg gacccaaaag     5100

cactctgggc cattccttct gaacttctgt cggttcccat gcaagccttt ccatgttgcc     5160

tctcagggtt taacatttca gaaggattat gttctcaaga gggaaatgac tatttctatg     5220

aaataataac agaagatgtg ttggaaataa caatactaga aatcagaagg gatgtttgtg     5280

atatcccttt agcaattgtt gacttgaaaa gcaaaggtaa aagtattaat gagaaaatgg     5340

agaaatattc taagactggt attaaaagtg ctcttcccta tgaaaatatt gactcagaga     5400

taaagcagac tcttgggtcc tacaatcttg atgtaggact taagaaatta agtaataaag     5460

ctgtacaaaa taaaatatat atggaacaac agacagatga gcttgctgaa ataactgaaa     5520

aagatgtaaa cattattgga accaaaccaa gtaacttccg tgaccctaaa actgataaca     5580

tttgtgaagg gtttgaaaac ccctgcaaag ataaaattga tactgaggaa ctggaaggtg     5640

aattagagtg ccatctggtt gacaaagcag agtttgatga taaatacctg attacaggat     5700

ttaacacatt actaccacat gctaatgaaa caaaggagat actagaactg aattcacttg     5760

aggtgccgct ttctcctgat gatgaatcaa aagaattctt agaactggaa tctattgagt     5820

tacagaattc tctggtggtg gatgaagaaa aaggggagct aagcccggtg ccaccgaatg     5880

tgccactctc ccaagagtgt gtcacaaaag gcgccatgga gctatttaca ctgcagcttc     5940

ctctcagctg tgaagctgag aaacagccag aactagaact acctacagcc cagctgcctt     6000

tagatgacaa gatggatcct ttgtctttag gagttagtca gaaagcacag gaatccatgt     6060

gtactgagga catgagaaag tcaagttgtg tagaatcttt tgatgaccag cgcaggatgt     6120

cattgcatct acatggagca gattgtgatc ctaaaacaca gaatgaaatg aatatatgtg     6180

aagaagaatt tgtagagtat aaaaacaggg atgccatttc ggcattgatg cctttgttct     6240

ctgaggaaga aagcagtgat ggaagcaagc acaataatgg tttaccagat catatctcag     6300

ctcaactaca gaacacctac actctgaaag cctttactgt tggatctaaa tgtgttgtgt     6360

ggtcaagtct aagaaacaca tggtctaaat gtgagatttt agaaacagct gaagaaggaa     6420

caaggaaaag gggtttggag gtgatggaga tttaaccgtg gatctatagc tgtggccaat     6480

cagtcagaag ctgcccttga acaagtggca tcttacgcag accaacagag tatttgagaa     6540

aattgaaaac atgtaaccac aagaagttgt cattttcaaa aacttctata taggtggaaa     6600

acaaattagg tctcaggttg atggtggggt gtgtttatag tgatcctgtt atatatacag     6660

atctgggatc tttcgtcttt attgtcttac gtttctaatt agttgggagg atttattttg     6720

ctaaacagtt tactaacaca ttacatttca aaaactattt tggtaccttt caaatacagt     6780

gtttaaatta aaatagaaaa ataagggctc atgacaagta cattatttga ttctacttag     6840

gatagctttt tagcaggatc tccttcagaa tttttgtctt gactttgaat ctttgcctgt     6900

ttgtctaaac atttgactaa cattctgttt gaatttggaa gtattctaat acaagatttg     6960

aataaagttt atccttaaat aaagtttatc cttaatatga tggtctcatt ttattaaaaa     7020

ggaaatagaa ctcttaaata tacttggttc catctctcct ctgtaatgga ggattgggga     7080

aagcatagta atattaaatg ttagctctta tgtattagtc acttagctta tactttaaat     7140

gcattttttc actttattca tcaactttga agtgcatatc aatattatcc atattttata     7200

ggtgagaaaa ttgaagcttc ataaagaggt taaataactt gcctaaggtc agatagctga     7260

tgagtctcag aggcttgatc aaacccagac ctacctaact ttgaagccca tgacttttta     7320

aacatgattt tgcaaagcat agatcttagc ttttagaaac agatctgagc tatatgctgc     7380

ttaacagata tgtgacatgg gcaaattatg taatattttg aactttgatc ttcatctgta     7440

aagtggtgat aataaaacct ttcttgcagt gtttttttaa gatgagaaat aattgatata     7500

aagtccctga aaaggagtag gcatttgata aatgtgtctt tctttaccct gaaaaatact     7560

cagtgtgcac tatgttaggt tatttctttt taaccttaac ttattagata ttttcaatag     7620

ttattttctc ctttcagcat cagcatgcgc caccaacaaa agactgtaaa aaacaaacaa     7680

acaaaaaagt gttgaatggg acatccatac agttggaatg cttatttcta aaatgaatag     7740

ggaaaaggtt tgctaaatga gactggggta aaggtgtatc tctgtgaagc attatcagac     7800

tctgaagcct aatggaaata gaattatgaa ccttaaaaac ccattataat ttccgtaagt     7860

agaagggaga gaggtttgca ttaaaagtaa ttgaggtaga tgagtatatt acttattcct     7920

ggaataatga atagacaagt ttggcttact catatagata atataatgtg aattgccaga     7980

agcaaagctc agagaagatg cattaggatc agattatagg aagccttcaa tttcaagctg     8040

agtttaactc cctattttaa aaaatttaat ctgaatggct acagaagtaa aatttctcag     8100

aatgagtgac tttgcacctg acaccactaa gataggacta gggtaccaaa tgagtggtat     8160

aaatttttat gtcccctggg aaataaaatc attttccatg attcccatat ttataagtat     8220

aaattcttaa gctatatttt tacctccatt taatcgtgtt attctgtttt actactacat     8280

atagaattga aaacattaaa taaaattaac tggaatatga agaagctaaa tgtaattctg     8340

aatgttttat tatccttcac agcctttgtg tgagtaacta atgtattcta actggaatcc     8400

ctgctatatg ctgtaatacc tgtggaacct ttctttagca agtagaatgc cttaaagaat     8460

taaagaaagt gtcaaaaaat taccaattta atccactgcc tttgcctcat ctctaatatt     8520

cttaaccctt ctctactcct tttagtcatc atttgaaatt gtgtagtacc accaatcctg     8580

tgctgaaaca atggcttttg cttgttctaa tttttcttac cgtgaccaaa agtcaaagag     8640

aagagctgcc aaattctacc tagaatatca tgttgctata attaaactcc actgcccata     8700

gtagataata aaaggcaaga aattgttttt tactctatgt ttagggagtc ttgtatcatt     8760

gcaacaggtt ttcactggga ttttgcctgt tttaatctac ttgtctgtca aagtaatgta     8820

aaaacagttt ttaacttcga cactgaaaag gaatcatctt taaaattaaa atttaggctg     8880

atatgaa                                                               8887


<210> 4433
<211> 543
<212> DNA
<213> Homo sapiens

<400> 4433
gagtcggtgg tggcccaaag tccaggccgc atccaccgcc cggcgcctag cgcaggggca       60

gcagccgggt cgccacagga ggggccccgg gtgttcttgc cggcttgggg gaactttccc      120

agggtcagcc cggaggcgcc ctgcagcccc ggcatttggc taaacaaagc aagcgctgcc      180

ggcgcggccc gcccgagggc gccgcgggaa gaacctgggc aggtggctcc gctgccggat      240

gggagtgccc cagtgtgctg gatgaagctg gcgcatgcac catgtcatca tgtgtctcta      300

gccagcccag cagcaaccgg gccgcccccc aggatgagct ggggggcagg ggcagcagca      360

gcagcgaaag ccagaagccc tgtgaggccc tgcggggcct ctcatccttg agcatccacc      420

tgggcatgga gtccttcatt gtggtcaccg agtgtgagcc gggctgtgct gtggacctcg      480

gcttggcgcg ggaccggccc ctggaggccg atggccaaga ggtccccctt gacacctccg      540

ggt                                                                    543


<210> 4434
<211> 2512
<212> DNA
<213> Homo sapiens

<400> 4434
aagaaacaag atggcggctg aaggcgatcc ggagtggggc cccacccccc ccagcaccag       60

cgccaccacc gcggcccgga gggccgtcaa caaagtggtg tacgatgacc acgagagcga      120

ggaggaggag gaagaggagg acatggtctc cgaggaggag gaggaggagg acggcgacgc      180

cgaggagacc caggattctg aggacgacga ggaggatgag atggaagagg acgacgatga      240

ctccgattat ccggaggaga tggaagacga cgacgacgac gccagttact gcacggaaag      300

cagcttcagg agccatagta cctacagcag cactccaggt aggcgaaaac caagagtaca      360

tcggcctcgt tctcctatat tggaagaaaa agacatcccg ccccttgaat ttcccaagtc      420

ctctgaggat ttaatggtgc ctaatgagca tataatgaat gtcattgcca tttacgaggt      480

actgcggaac tttggcactg ttttgagatt atctcctttt cgctttgagg acttttgtgc      540

agctctggtg agccaagagc agtgcacact catggcagag atgcatgttg tgcttttgaa      600

agcagttctg cgtgaagaag acacttccaa tactaccttt ggacctgctg atctgaaaga      660

tagcgttaat tccacactgt atttcataga tgggatgacg tggccagagg tgctgcgggt      720

gtactgtgag agtgataagg agtaccatca cgttcttcct taccaagagg cagaggacta      780

cccatatgga ccagtagaga acaagatcaa agttctacag tttctagtcg atcagtttct      840

tacaacaaat attgctcgag aggaattgat gtctgaaggg gtgatacagt atgatgacca      900

ttgtagggtt tgtcacaaac ttggggattt gctttgctgt gagacatgtt cagcagtata      960

ccatttggaa tgtgtgaagc cacctcttga ggaggtgcca gaggacgagt ggcagtgtga     1020

agtctgtgta gcacacaagg tgcctggtgt gactgactgt gttgctgaaa tccaaaaaaa     1080

taaaccatat attcgacatg aacctattgg atatgataga agtcggagga aatactggtt     1140

cttgaaccga agactcataa tagaagaaga tacagaaaat gaaaatgaaa agaaaatttg     1200

gtattacagc acaaaggtcc aacttgcaga attaattgac tgtctagaca aagattattg     1260

ggaagcagaa ctctgcaaaa ttctagaaga aatgcgtgaa gaaatccacc gacacatgga     1320

cataactgaa gacctgacca ataaggctcg gggcagtaac aaatcctttc tggcggcagc     1380

taatgaagaa attttggaat ccataagagc caaaaaggga gacattgata atgttaaaag     1440

cccagaagaa acagaaaaag acaagaatga gactgagaat gactctaaag atgctgagaa     1500

aaacagagaa gaatttgaag accagtccct tgaaaaagac agtgacgaca aaacaccaga     1560

tgatgaccct gagcaaggaa aatctgagga gccaacagaa gttggggata aaggtaactc     1620

tgtgtcagca aatcttggcg acaacacaac aaatgcaact tcagaagaga ctagtccctc     1680

tgaagggagg agccctgtgg ggtgtctctc agaaaccccc gatagcagca acatggcaga     1740

gaagaaggtg gcatctgagc tcccccagga tgtgccagaa gaacctaaca agacatgtga     1800

gagcagtaac actagtgcta ccactacctc catccagcct aatctggaaa acagtaacag     1860

cagcagtgaa ctaaattctt cccagagtga atctgctaag gcagctgatg atcctgaaaa     1920

tggagaaaga gaatctcata cacctgtctc tattcaggaa gagatagtag gtgatttcaa     1980

atcggagaag tccaacgggg agctaagtga atctcctgga gctggaaaag gagcatctgg     2040

ctcaactcga atcatcacca gattgcggaa tccagatagc aaacttagtc agctgaagag     2100

ccagcaggtg gcagccgctg cacatgaagc aaataaatta tttaaggagg gcaaagaggt     2160

actggtagtt aactctcaag gagaaatttc acggttgagc accaaaaagg aagtgatcat     2220

gaaaggaaat atcaacaatt attttaaatt gggtcaagaa gggaagtatc gcgtctacca     2280

caatcaatac tccaccaatt catttgcttt gaataagcac cagcacagag aagaccatga     2340

taagagaagg catcttgcac ataagttctg tctgactcca gcaggagagt tcaaatggaa     2400

cggttctgtc catgggtcca aagttcttac catatctact ctgagactga ctatcaccca     2460

atatggcgag aatctttagg acataccagg ttacaccgga tgacatcaat tg             2512


<210> 4435
<211> 1186
<212> DNA
<213> Homo sapiens

<400> 4435
ctttcctcac tgcacgctct tgcccctcct cttttctctc ctgcccgtgt tcttcccgcc       60

gcctgacctg gcccgcccgc ctttccagtc tggccgggcg ggggcctgaa gcacggcggc      120

tcgggccgtg ggaccgtgtt cacacccttt ccagaaattc ttggctggta accgcgaaac      180

cgactggagc aggagctggg agaactggag aaaactgctc taatctcact tgactccagc      240

taggagctga tgctgcatcg taataacatt tgcagagcgc tttcacaggc gctggagtga      300

cttgtctgag attcctccag aactgagccc tttgttggaa ccatacccca gcccatggtc      360

ccatgactag gtggatagta ctccttgtac ctcctgcaac ccagaaccct ggctgaccac      420

tttgaaggag gatgctccag cagacatgga cgtctcgctg cctaatgaag ttctatgctg      480

tggtggccac ctcacctgca tcttgggaga gccacaagat tgcagagagg atagaacaga      540

ggatcctgaa ctccaaccct gtcatggaag cttttgggaa tgcgtgtaca ctgaggaata      600

acaacagcag tcgctttggg aagttcatcc agctccagct gaacagggct cagcaaatga      660

ctggagccgc agtccagacc tacctcctag agaaaactcg agtggcctgc caggcttcca      720

gtgagaggaa cttccacatc ttctatcaga tttgcaaagg agccagtgag gacgagaggc      780

tccagtggca ccttcctgag ggagctgcct tctcctggct gcccaaccca gagaggagct      840

tagaagagga ttgttttgag gtgaccagag aggccatgct ccatttgggc attgacaccc      900

ctacccagaa caacatcttt aaggtcagaa gaaaagccac gccacttaag tttggcagag      960

atgacgggca gccctttgca tagagctttt ccctggactt ggagttggtc tttccctgag     1020

gatctaggac tttgggcccc tctgggctac ctccaaggaa tcagtcacct ctgttctgct     1080

gagtctggag accaggtggt ggggtggacg gggcataagg aagagtgatg catacacagt     1140

gctagagtac agaatgcagt aagtgatcca tgggggcaga gagcaa                    1186


<210> 4436
<211> 885
<212> DNA
<213> Homo sapiens

<400> 4436
gagcataaga acttgcctta gtgaagatgc aaaagagatt cagaacaaaa tagaggtaga       60

agcagatggg caaacagaag agattttgga ttctcaaaac ttaaattcaa gaaggagccc      120

tgtcccagaa acatcgaatg aatgctgaaa ttcctagtct ggtttcttca gtggtgtgtt      180

tgtgttttag tacaacctgc aaaagagtta ctccattgtc taaaaatgca aatgagaatt      240

tccaaatata caaaatgcct ccaagctcaa atagctataa ctgtaccaaa gacatggaag      300

aaaccaaaag atcggacccg aaccactgaa gagatgttag aggcagaatt ggagcttaaa      360

gctgaagagg agctttccat tgacaaagta cttgaatctg aacaagataa aatgagccag      420

gggtttcatc ctgaaagaga cccctctgac ctaaaaaaag tgaaagctgt ggaagaaaat      480

ggagaagaag ctgagccagt acgtaatggt gctgagagtg tttctgaggg tgaaggaata      540

gatgctaatt caggctccac agatagttct ggtgatgggg ttacatttcc atttaaacca      600

gaatcctgga agcctactga tactgaaggt aagaagcagt atgacaggga gtttctgctg      660

gacttccagt tcatgcctgc ctgtatacaa aaaccagagg gcctgcctcc tatcagtgat      720

gtggttcttg acaagatcaa ccaacccaaa ttgccaatgc gaactctgga tcctcgaatt      780

ttgcctcgag gaccagactt tacaccagcc tttgctgatt ttggaaggca gacacctggt      840

ggaagaggcg tacctgtaag tgcaagttcc ctacaactca cttag                      885


<210> 4437
<211> 1392
<212> DNA
<213> Homo sapiens

<400> 4437
ttcgccggcc gcgcggccag atgagggggg cgatggagct ggagcctgag ctgctgttgc       60

aggaggcccg cgagaacgtg gaggcagcgc agagctaccg gcgggagctg ggtcaccggc      120

ttgaggggct gcgtgaggcg cggaggcagg tgaaatcgcc atgcttggtg gtgtgggaga      180

agagaatgag aaactgtgga gctttaccaa aaaggcctcg cacattcagt tggacagctt      240

accagaagta cctttactgg ttgatgtgcc ttgtttatct gctcagttgg atgactcaat      300

tcttaacata gtgaaagacc acatttttaa gcatggaaca gtagcatctc gcccaccagt      360

acagatagaa gaactaatag agaaacctgg aggcatcatt gtacgatggt gtaaggtgga      420

tgatgacttt acagcccaag attacaggct ccagtttcgt aaatgtactt caaatcattt      480

tgaggatgta tatgtaggtt ctgaaactga attcatagta ttgcacatag accccaacgt      540

tgattaccag ttcagagtct gcgcccgagg agatggccga caggagtgga gtccttggag      600

tgtcccccag ataggtcatt ccacattggt gcctcatgag tggacagctg gttttgaggg      660

gtacagtctg agcagtcgaa gaaatatagc acttcggaac gattctgaat catcgggtgt      720

tctctactcc agagctccga cttatttctg tgggcagaca ttaacattca gagttgaaac      780

tgtgggacag ccagacagaa gagatagcat aggagtgtgt gcagaaaaac aggatggata      840

tgactctctg cagcgggatc aagctgtgtg cattagtaca aatggtgcag tttttgtcaa      900

tggaaaagaa atgacaaatc agttacccgc agttacttct gggtccactg tcacgtttga      960

cattgaagcc gtgactctag gaaccaccag taataatgaa ggtggacact tcaagcttcg     1020

agtaactata agttcaaata atagagaagt ggtttttgac tggttacttg atcagtcttg     1080

tggttctctt tactttggat gctcattttt ctatcctgga tggaaagtgt tagtgtttta     1140

gatgtttggg tgcttggctt tggttttcag ggtctaacgt agctgtcctc agcccagcgt     1200

agttgtaatt gctttaaaaa aaaagttgaa ttcatctcta acttaggcca ttggaaagtg     1260

tttactggat tcattttgta atattttagc aaaaagagac ttcaatgttg tggacaaaat     1320

catacaattc agtcaatttt atttttagca tactgttaaa tatcacatca caataaaaat     1380

caaattggca tt                                                         1392


<210> 4438
<211> 2633
<212> DNA
<213> Homo sapiens

<400> 4438
aaagtggtgt acgatgacca cgagagcgag gaggaggagg aagaggagga catggtctcc       60

gaggaggagg aggaggagga cggcgacgcc gaggagaccc aggattctga ggacgacgag      120

gaggatgaga tggaagagga cgacgatgac tccgattatc cggaggagat ggaagacgac      180

gacgacgacg ccagttactg cacggaaagc agcttcagga gccatagtac ctacagcagc      240

actccaggta ggcgaaaacc aagagtacat cggcctcgtt ctcctatatt ggaagaaaaa      300

gacatcccgc cccttgaatt tcccaagtcc tctgaggatt taatggtgcc taatgagcat      360

ataatgaatg tcattgccat ttacgaggta ctgcggaact ttggcactgt tttgagatta      420

tctccttttc gctttgagga cttttgtgca gctctggtga gccaagagca gtgcacactc      480

atggcagaga tgcatgttgt gcttttgaaa gcagttctgc gtgaagaaga cacttccaat      540

actacctttg gacctgctga tctgaaagat agcgttaatt ccacactgta tttcatagat      600

gggatgacgt ggccagaggt gctgcgggtg tactgtgaga gtgataagga gtaccatcac      660

gttcttcctt accaagaggc agaggactac ccatatggac cagtagagaa caagatcaaa      720

gttctacagt ttctagtcga tcagtttctt acaacaaata ttgctcgaga ggaattgatg      780

tctgaagggg tgatacagta tgatgaccat tgtagggttt gtcacaaact tggggatttg      840

ctttgctgtg agacatgttc agcagtatac catttggaat gtgtgaagcc acctcttgag      900

gaggtgccag aggacgagtg gcagtgtgaa gtctgtgtag cacacaaggt gcctggtgtg      960

actgactgtg ttgctgaaat ccaaaaaaat aaaccatata ttcgacatga acctattgga     1020

tatgatagaa gtcggaggaa atactggttc ttgaaccgaa gactcataat agaagaagat     1080

acagaaaatg aaaatgaaaa gaaaatttgg tattacagca caaaggtcca acttgcagaa     1140

ttaattgact gtctagacaa agattattgg gaagcagaac tctgcaaaat tctagaagaa     1200

atgcgtgaag aaatccaccg acacatggac ataactgaag acctgaccaa taaggctcgg     1260

ggcagtaaca aatcctttct ggcggcagct aatgaagaaa ttttggaatc cataagagcc     1320

aaaaagggag acattgataa tgttaaaagc ccagaagaaa cagaaaaaga caagaatgag     1380

actgagaatg actctaaaga tgctgagaaa aacagagaag aatttgaaga ccagtccctt     1440

gaaaaagaca gtgacgacaa aacaccagat gatgaccctg agcaaggaaa atctgaggag     1500

ccaacagaag ttggggataa aggtaactct gtgtcagcaa atcttggcga caacacaaca     1560

aatgcaactt cagaagagac tagtccctct gaagggagga gccctgtggg gtgtctctca     1620

gaaacccccg atagcagcaa catggcagag aagaaggtgg catctgagct cccccaggat     1680

gtgccagtag gtgatttcaa atcggagaag tccaacgggg agctaagtga atctcctgga     1740

gctggaaaag gagcatctgg ctcaactcga atcatcacca gattgcggaa tccagatagc     1800

aaacttagtc agctgaagag ccagcaggtg gcagccgctg cacatgaagc aaataaatta     1860

tttaaggagg gcaaagaggt actggtagtt aactctcaag gagaaatttc acggttgagc     1920

accaaaaagg aagtgatcat gaaaggaaat atcaacaatt attttaaatt gggtcaagaa     1980

gggaagtatc gcgtctacca caatcaatac tccaccaatt catttgcttt gaataagcac     2040

cagcacagag aagaccatga taagagaagg catcttgcac ataagttctg tctgactcca     2100

gcaggagagt tcaaatggaa cggttctgtc catgggtcca aagttcttac catatctact     2160

ctgagactga ctatcaccca attagaaaac aacatccctt catcctttct tcatcccaac     2220

tgggcatcac atagggcaaa ttggatcaag gcagttcaga tgtgtagcaa acccagagaa     2280

tttgcattgg ctttagccat tttggagtgt gcagttaaac cagttgtgat gctaccaata     2340

tggcgagaat ctttaggaca taccaggtta caccggatga catcaattga aagagaagaa     2400

aaggagaaag tcaaaaaaag agaagaaaca ggaagaagaa gaaacgatgc agcaagcgac     2460

atgggtaaaa tacacatttc cagttaagca tcaggtttgg aaacaaaaag gtgaagagta     2520

cagagtgaca ggatatggtg gttggagctg gattagtaaa actcatgttt ataggtttgt     2580

tcctaaattg ccaggcaata ctaatgtgaa ttacagaaag tcgttagaag gaa            2633


<210> 4439
<211> 3862
<212> DNA
<213> Homo sapiens

<400> 4439
agcctggctg aggcagccgc gcaggtcgca gggccagcgt ccgcgaggac ggcccggctg       60

ggcggccccg agctctgtgg cgctgtggag gagcgggagc gcggccgagg aagcggggcg      120

ccgagggggt cggcggcctt cgggaaattt ccgccgaccc ttcgctcccg gctctaaaag      180

ttcctgattt cctatttcct tttaaatccc gagtggctgt tagctcttcg cctgcacttt      240

ttcttcccca ggagataagg gggagtgtga ggaacggagc gaataatata aaaaaggatt      300

tcctcccgga agagagcggc agttcggaga gatttttctt aaggaagcag aagcggcgtt      360

tgcggccgct gcaggcgccg ggccctgccg gccacactat gcgcgagccg gccccgggct      420

gctgaggcgc ggggacgcgg aagcggaggc cgagcgcgcc ggcccgacat ggcgccggag      480

ctgaccccgg aggaggagca ggctaccaag cagtttctcg aagagattaa caagtggaca      540

gttcagtaca atgtttcccc gctgtcttgg aatgtggctg tcaagttcct catggcaagg      600

aagtttgatg tgctccgtgc catagaattg ttccactcct acagagaaac tcgaaggaag      660

gaaggcattg taaagctgaa acctcatgag gaacctcttc gttctgagat cctcagtgga      720

aaattcacca tcttaaatgt tcgggaccca acaggagcct ccattgccct ctttactgcc      780

aggttgcatc atccccacaa gtcagtccaa catgtggtac ttcaggctct gttttacttg      840

ctagacagag ctgtggatag ctttgaaact cagaggaatg gactggtgtt tatctatgac      900

atgtgtggtt ctaattatgc caactttgag ctggatcttg gcaagaaagt cctaaacctg      960

ctgaagggag catttccagc tcgtttgaag aaggtgctga ttgtgggggc acccatatgg     1020

ttccgagtgc cctattccat catcagtctc ctcctgaagg acaaagtccg ggagaggatt     1080

caaatattaa agacatctga ggtcacgcag catctgccca gggagtgtct tccagaaaac     1140

ctgggtgggt acgtcaaaat tgatctcgcc acttggaatt tccagttcct accccaggtg     1200

aacggccacc cagatccctt cgatgagatc atcctgttct ccctccctcc tgccttagac     1260

tgggactcag tacatgttcc aggtccccat gctatgacca tccaagagtt ggtggactat     1320

gttaatgcca ggcaaaagca aggaatctat gaggaatatg aagacattcg tcgtgagaac     1380

cctgttggca ctttccactg ttccatgtct ccaggaaacc tagagaaaaa ccgttatggg     1440

gatgtaccct gcctggacca aactagagtg aagctaacaa agcgaagtgg ccatactcag     1500

acagattaca tcaatgccag tttcatggat ggctacaagc agaagaatgc ttacattggc     1560

acacaaggtc ctttggagaa tacctatcgt gatttctggc tcatggtatg ggagcaaaaa     1620

gtcttggtga ttgtcatgac cacccgcttt gaggaaggcg gcaggagaaa gtgtggccag     1680

tactggcctt tagaaaaaga ctctcggatc cgatttggct tcctcacagt gaccaatcta     1740

ggcgtggaga acatgaatca ttataagaaa acaacgctag aaattcacaa cacagaggaa     1800

cggcagaaac gccaggtgac ccacttccag ttcttgagct ggccagacta tggtgtccct     1860

tcctcagcag cttccctcat tgacttcttg agagtggtca gaaaccagca gagtctggct     1920

gtgagcaaca tgggagcacg ctccaaaggg cagtgccctg agccacccat tgtggtccat     1980

tgcagtgcag gcattggcag gacaggtacc ttctgctcac tggacatctg cctggcacag     2040

ctggaggagc ttggcaccct taatgtgttc cagacggtgt cacgcatgag gacccagagg     2100

gccttcagca tccagacccc tgagcagtac tatttttgct acaaggccat cctggagttc     2160

gcagagaagg agggcatggt atcctctggc caaaacctgc tggccgtgga gagtcagtaa     2220

ctctcctacg aacctcctac ctgttggcca gccttcctta aactaccctg gacaccgctg     2280

agcctatagg ttgccatcag ttacgctgaa gccatggatc aacttctttc ttgtgtctcc     2340

cagcacacgt gtgcacgcaa ggcagccttt ccctttggct agataaatgt ggtgaaattg     2400

ccactagaaa gggccagtag caatgtgttc ttaattccta gcatctgcta tcaaactgtg     2460

ccttattaaa accaaattgt ggctattgat ttttgctagg gtccccgagg taagtgggga     2520

aggaacctcc ctcctccttt ctcccgccat tctttttctg aggtctcctg tctcccactc     2580

cttccctttc ctaggatttt atggggaggt ttgatgagca tttgcctttc tccccagaga     2640

gcttgaccaa gttacatatt ctagagatcg tcctgagtgc caagcacgtt tataagtagg     2700

gcgtgtattc cagtcctttc tgtcattctg tgtgtgtgtg tgtgtgcact tatgtgtatg     2760

ggtccatatg tacgtgtgta tataatatat attgtatgtg ataatatgat cgtattctat     2820

aaatacatat acacacgata ctcctttcca gaagttcctg gggctccgtg ttgcagttca     2880

ggactccttg cttcttggac cctactattt atcctggact agcttgggtt ggtgatcatg     2940

tctcctcttg tcaggctaca gagtggtgga agaggacaca cacacatctc ctccatgttc     3000

ctgccacagg gccccttcct taagtaatga cttatctcct tccagttgcc acctgttgga     3060

gccaagaatg tattagtttg tggtgacact gggttagctc agcatggatt tcccttatcc     3120

gatgattttt ctacatttac ttggccaatt tggggaacag acctccactg tgattccata     3180

ctctctcttt gctttcacta tcccagggat gggaggcgga gggtagagat gaactcactg     3240

agcagccaga gccaaatgca atcggtacga atcttagaag gaaggagggg gagcccaggt     3300

atgagaaaga aaaaaccact aagaaaatac ctccctggga ggatgagctg gggccctttt     3360

tcttttgctg gatggttcct ttatgcagct tggccctgtc taccgagatg cccatctctt     3420

cctgcctgct agcctgctag accctcaaac tgggtgggtt ctgtgtcaat aaaaagcttc     3480

accccctggc tgagtgaggt ggtcccctgc aatcactgtt tgtcccctac ccacccaacc     3540

tgtccctgcc tgctcccagc ccactcatcc ttatgtgcta gggataaatc aagagtcctc     3600

agcactccac attcccaaaa aatcccagga actcctaaac cttcccctgt gacagaagat     3660

gaggttggca gctgatcaga cctcaataat tttatactgt aataagctct ttgaatgtgt     3720

atattattat tttttacaat catttcattt tgtatttaat atcaatggac tgagtctgat     3780

tcagaaaata attgtaatgt tcatattcaa tatcttacag tgatacagtt ttgtatttac     3840

atataaatat accgacatga tc                                              3862


<210> 4440
<211> 526
<212> DNA
<213> Homo sapiens

<400> 4440
agggcagcct gctcgacaag gccccttggc agacagtcag ctccctccaa ggccaaaccc       60

caagttcaac atacatcttt ctctcccatt tctgcaagca taactgtgaa cagcataatt      120

cttttccgtt actatggcaa tgacggcagg gactacaaca acctttccta tgagcaacca      180

tacccgggaa agagtgactg tagccaagct cacattggag aatttttata gcaacctaat      240

tttacagcat gaagagagag aaaccaggca gaagaaatta gaagtggcca tggaagaaga      300

aggattagca gatgaagaga aaaagttacg tcgatcacaa cacgctcgca aagaaacaga      360

gttcttacgg ctcaaaagga ccagacttgg cttggatgac tttgagtctc tgaaagttat      420

aggaagagga gcttttggag aggtgcggtt ggtccagaag aaagatacag gccatatcta      480

tgcaatgaag atattgagaa agtctgatat gcttgaaaaa gagcag                     526


<210> 4441
<211> 847
<212> DNA
<213> Homo sapiens

<400> 4441
agactgccat aagatggcgt ccgtggcggc tgcacgagca gttcccgtgg gcagtgggct       60

caggggcctg caacggaccc tacctcttgt agtgattctc ggggccacgg gcaccggcaa      120

atccacgctg gcgttgcagc taggccagcg gctcggcggt gagatcgtca gcgctgactc      180

catgcaggtc tatgaaggcc tagacatcat caccaacaag gtttctgccc aagagcagag      240

aatctgccgg caccacatga tcagctttgt ggatcctctt gtgaccaatt acacagtggt      300

ggacttcaga aatagagcaa ctgctctgat tgaagatata tttgcccgag acaaaattcc      360

tattgttgtg ggaggaacca attattacat tgaatctctg ctctggaaag ttcttgtcaa      420

taccaaggta agtttagttc actcgtaact cactgaggaa atggattgct ctttcttgct      480

gtctaatttc agtgggagaa aggttgactc ttgcctattt cttataccca gcaactataa      540

ttttcctact taatattctc aagcaaatgc cacctccatg tgtgaagtgt gttcctccag      600

gctggttcca aactcctagg ctcaagcgat cctcctgcct cagcctaccg aagtgctggg      660

attatagtca tgagccacag tactcagcca agaaaaggat ttcttcaggt agggttgtcc      720

tttgcacggc aggggggtgg ggcacaaatt gtaatatcta agttttttca cccccttaaa      780

ggcaatgtat aacctcatta agaatgcatg ttttagatta atgaagttta tacttttcag      840

tatccaa                                                                847


<210> 4442
<211> 3497
<212> DNA
<213> Homo sapiens

<400> 4442
gcggtgtttg tctgccggac tgacgggcgg ccgggcggtg cgcggcggcg gtggcggcgg       60

ggaagatggc ggcgtcctcc ctggaacaga agctgtcccg cctggaagca aagctgaagc      120

aggagaaccg ggaggcccgg cggaggatcg acctcaacct ggatatcagc ccccagcggc      180

ccaggcccac cctgcagctc ccgctggcca acgatggggg cagccgctcg ccatcctcag      240

agagctcccc gcagcacccc acgccccccg cccggccccg ccacatgctg gggctcccgt      300

caaccctgtt cacaccccgc agcatggaga gcattgagat tgaccagaag ctgcaggaga      360

tcatgaagca gacgggctac ctgaccatcg ggggccaggt accaccttca ctgtggcggg      420

gagagggagg aggcccagcc aggctggacc catcctggga gcgccagtgg ggggcagggg      480

gcggtggcag accagggacc ctccaaccct ccctctcctc ccagcgctac caggcagaaa      540

tcaacgacct ggagaacttg ggcgagatgg gcagcggcac ctgcggccag gtgtggaaga      600

tgcgcttccg gaagaccggc cacgtcattg ccgttaagca aatgcggcgc tccgggaaca      660

aggaggagaa caagcgcatc ctcatggacc tggatgtggt gctgaagagc cacgactgcc      720

cctacatcgt gcagtgcttt gggacgttca tcaccaacac ggacgtcttc atcgccatgg      780

agctcatggg cacctgcgct gagaagctca agaagcggat gcagggcccc atccccgagc      840

gcattctggg caagatgaca gtggcgattg tgaaggcgct gtactacctg aaggagaagc      900

acggtgtcat ccaccgcgac gtcaagccct ccaacatcct gctggacgag cggggccaga      960

tcaagctctg cgacttcggc atcagcggcc gcctggtgga ctccaaagcc aagacgcgga     1020

gcgccggctg tgccgcctac atggcacccg agcgcattga ccccccagac cccaccaagc     1080

cggactatga catccgggcc gacgtatgga gcctgggcat ctcgttggtg gagctggcaa     1140

caggacagtt tccctacaag aactgcaaga cggactttga ggtcctcacc aaagtcctac     1200

aggaagagcc cccgcttctg cccggacaca tgggcttctc gggggacttc cagtccttcg     1260

tcaaagactg ccttactaaa gatcacagga agagaccaaa gtataataag ctacttgaac     1320

acagcttcat caagcgctac gagacgctgg aggtggacgt ggcgtcctgg ttcaaggatg     1380

tcatggcgaa gactgagtca ccgcggacta gcggcgtcct gagccagccc cacctgccct     1440

tcttcaggta gctgcttggc ggcggccagc cccacagggg gccaggggca tggccacagg     1500

cccccctccc cacttggcca cccagctgcc tgccagggga gacctgggac ctggacggcc     1560

acctaggact gaggacagag agtggggggt gcccacccac cccccccgcc ccgggcctac     1620

caagcccccg cccttcccac cccggggtca gccggccgtg tgcgtccccc gacagacact     1680

gtgaacggaa gacagcaggc cgcgatcaga gtcgctgttc attcagccgc agcctctggg     1740

ccggggcggc ccccaggggc caggagagag ccctggagtc ccgcagccac catgcacgct     1800

cccagcgtgc tgtgtccttc gccactccca cgcgcccgtt cctcttccgt cgccctctgt     1860

cccctgctct acctctctgt ccttgtctgg ctctcccgtc accctccctg cctctgtctc     1920

tcttctggcc tgagcctggg cccagccacc tcctgacggg tcccctgggt ctgcataggt     1980

ctcccatggc gcaatgagtc agtggccccc agccaggcag tgtgggcatt gccactgcgg     2040

ctggacgggg ctgcgcgctc gcgctctctc tctctctctc tctctctctt tgatctcagg     2100

gggtcctttt tggagtttat tgtattttat tgtacttggt ggggtgtttg gggtgggggc     2160

ggaggagagc ttgttctcgt ggggttgtcg gtaccttcag aaacttttac caaagtcacg     2220

attagctgct tgtggtgggg ccccaaccgc cctcgggcac tggggagctg ggctggggct     2280

gctgctctgg ggtctccggg ggccacagct tggggtgagt tgaagacctc aggggatgtg     2340

gaggggtctg cggggccctg gccgcacagg atggccttca gggaaggtgg tcttggggca     2400

tggtgcagag caggtgaccg gagggaatcg gtgacggagc ggggccaagg gaggggtccg     2460

gagggagtca gggatggagg gcagagggag tggatgtggg ggtttgagga cgtgtgacaa     2520

gctccagcag gggtgggggc cgggctgagg gtgggggtgc gaggtggtca ctcccatcgt     2580

gcccctggcc gtccctccac tcacccacac ctggcccagt ccacgttgag gtccaggact     2640

gggaaggacc gggtgagtgc accggggacc caggccaggt gccccccgga gcctgctggg     2700

gtggccagag caggaggggg tgtgtttcct ttttgtgggt gttgcatgca aatcaagtgg     2760

acaagaaaaa ataacaaaac aaaaaacaag aaaaaaaaaa cacaaaaccc cgtaaaatca     2820

caaagaaaat ccaacaccaa aggcgcagaa gccggctggc cgtggtgggg gcagcgtagg     2880

cgtagcatcc ctctcctctc acttagcctg ttgactcttg ttattatcat gatattcaca     2940

aaacgccgca tgtttaaaaa gtcatagatg tcatcttctc tctgccccca gggaggaaag     3000

ccaccttctc ttgccccttg gcccctttgt caggggccag gggtctgccg ggtgggggtg     3060

ccaacaggcc tggccctttc ctcccctgca tccagccatg ggggcctctg cgattgccgg     3120

aaggttgcat ggctggtccc agggccagca caggcccgag gccgggctgc ctggttttat     3180

ttttatttaa ctttattttc tgttttatga gtgtgtgtcc gcccaccccc acccccttca     3240

gtgttaagtg gggagccctg ggggagtctc tcctgcctcc cagcctctcc caagacctcc     3300

cccctcgtca ccagccatcc ctctggacca ggcagagggc ggaccgggtg ggcaggggcc     3360

tgagggtggc tcgggccagc ccaccagcca atggacccct cctcaggccg ccagtgtcgc     3420

cctgcccctt tttaaaacaa aatgccctcg tttgtaaacc cttagacgct tgagaataaa     3480

ccccttcctt ttcttcc                                                    3497


<210> 4443
<211> 2122
<212> DNA
<213> Homo sapiens

<400> 4443
aacgtagcta gctgcaagca gaggccggca tgaccaccga gcagcgacgc agcctgcaag       60

ccttccagga ttatatccgg aagaccctgg accctaccta catcctgagc tacatggccc      120

cctggtttag ggaggaagag gtgcagtata ttcaggctga gaaaaacaac aagggcccaa      180

tggaggctgc cacacttttt ctcaagttcc tgttggagct ccaggaggaa ggctggttcc      240

gtggcttttt ggatgcccta gaccatgcag gttattctgg actttatgaa gccattgaaa      300

gttgggattt caaaaaaatt gaaaagttgg aggagtatag attactttta aaacgtttac      360

aaccagaatt taaaaccaga attatcccaa ccgatatcat ttctgatctg tctgaatgtt      420

taattaatca ggaatgtgaa gaaattctac aggtataaaa gatgttgaaa cagaagatct      480

tgaggataag atggaaactt ctgacataca gattttctac caagaagatc cagaatgcca      540

gaatcttagt gagaattcat gtccaccttc agaagtgtct gatacaaact tgtacagccc      600

atttaaacca agaaattacc aattagagct tgctttgcct gctatgaaag gaaaaaacac      660

aataatatgt gctcctacag gttgtggaaa aacctttgtt tcactgctta tatgtgaaca      720

tcatcttaaa aaattcccac aaggacaaaa ggggaaagtt gtcttttttg cgaatcagat      780

cccagtgtat gaacagcaga aatctgtatt ctcaaaatac tttgaaagac atgggtatag      840

agttacaggc atttctggag caacagctga gaatgtccca gtggaacaga ttgttgagaa      900

caatgacatc atcattttaa ctccacagat tcttgtgaac aaccttaaaa agggaacgat      960

tccatcacta tccatcttta ctttgatgat atttgatgaa tgccacaaca ctagtaaaca     1020

acacccgtac aatatgatca tgtttaatta tctagatcag aaacttggag gatcttcagg     1080

cccactgccc caggtcattg ggctgactgc ctcggttggt gttggggatg ccaaaaacac     1140

agatgaagcc ttggattata tctgcaagct gtgtgcttct cttgatgcgt cagtgatagc     1200

aacagtcaaa cacaatctgg aggaactgga gcaagttgtt tataagcccc agaagttttt     1260

caggaaagtg gaatcacgga ttagcgacaa atttaaatac atcatagctc agctgatgag     1320

ggacacagag agtctggcaa agagaatctg caaagacctc gaaaacttat ctcaaattca     1380

aaatagggaa tttggaacac agaaatatga acaatggatt gttacagttc agaaagcatg     1440

catggtgttc cagatgccag acaaagatga agagagcagg atttgtaaag ccctgttttt     1500

atacacttca catttgcgga aatataatga tgccctcatt atcagtgagc atgcacgaat     1560

gaaagatgct ctggattact tgaaagactt cttcagcaat gtccgagcag caggattcga     1620

tgagattgag caagatctta ctcagagatt tgaagaaaag ctgcaggaac tagaaagtgt     1680

ttccagggat cccagcaatg agaatcctaa acttgaagac ctctgcttca tcttacaaga     1740

agagtaccac ttaaacccag agacaataac aattctcttt gtgaaaacca gagcacttgt     1800

ggacgcttta aaaaattgga ttgaaggaaa tcctaaactc agttttctaa aacctggcat     1860

attgactgga cgtggcaaaa caaatcagaa cacaggaatg accctcccgg cacagaagtg     1920

tatattggat gcattcaaag ccagtggaga tcacaatatt ctgattgcca cctcagttgc     1980

tgatgaaggc attgacattg cacagtgcaa tcttgtcatc ctttatgagt atgtgggcaa     2040

tgtcatcaaa atgatccaaa ccagagagga agagcaagag gtagcaagtg cttccttctg     2100

actagtaatg ctggtgtaat tg                                              2122


<210> 4444
<211> 4422
<212> DNA
<213> Homo sapiens

<400> 4444
cgcccagggc ggtagcgtga aacttggtgg aagacgctga ccagtcgtgt tggaatcaaa       60

acagcgggga ccctgcgcca tgtcgcgact gatcgtgaag aatctcccga atgggatgaa      120

ggaggagcgt ttcaggcagc tgtttgccgc cttcggcacg ctgacagact gcagcctgaa      180

gttcaccaaa gatggcaagt tccgcaagtt tggttttatt ggcttcaagt ccgaggaaga      240

ggcccagaag gcacagaagc atttcaacaa gagcttcatc gacacatccc ggatcacagt      300

ggagttctgc aagtcattcg gggacccggc caaacccaga gcctggagca aacatgccca      360

gaaaccaagc cagcccaagc agcctccaaa agactctact actccagaaa ttaagaaaga      420

tgagaagaag aaaaaggtgg caggtcaact ggagaagctg aaggaggata cagagttcca      480

ggagtttctg tcagttcatc agaggcgggc gcaggcagcc acttgggcga atgatggcct      540

ggatgctgag ccctcgaaag ggaagagcaa gccggccagt gactacctga acttcgactc      600

cgattctggg caggagagtg aggaggaggg agccggggag gacctggaag aagaggcaag      660

cctcgaacca aaggcagctg tgcagaagga gctgtcggac atggattacc tgaaatccaa      720

gatggtgaag gctgggtcgt cctcttcctc ggaggaagag gaaagtgaag atgaagccgt      780

gcactgtgat gaagggagtg aggccgagga agaggattcc tccgccaccc cagtcctgca      840

ggaaagagac agcaagggtg caggccaaga gcaagggatg ccagctggga aaaagagacc      900

accggaggcc agagccgaga cagagaaacc agcaaaccag aaggaaccca ccacctgcca      960

caccgtgaag ctgcggggag ccccgttcaa tgtcacagag aaaaatgtta tggaattcct     1020

ggcacccctg aaaccagtgg ccattcgaat tgtgagaaac gctcatggga ataaaacagg     1080

atacatcttt gtggatttca gcaatgaaga ggaagtgaag caagctctga aatgcaaccg     1140

ggagtacatg ggtgggcgct acatcgaggt gttcagggaa aagaacgtcc ccaccaccaa     1200

gggtgcacca aagaatacca ccaaatcctg gcaaggccgg atactcgggg agaacgaaga     1260

ggaggaggac ctggccgaat ccggaaggct ctttgtacgg aacctgccct acaccagcac     1320

cgaggaggat ctggagaagc tcttctccaa atatggtccc ctgtctgagc tccactaccc     1380

catcgacagc ctgaccaaga aacccaaggg ttttgcattc atcaccttca tgttccctga     1440

gcacgctgtg aaggcctact cggaggtgga cgggcaggta ttccagggca ggatgctcca     1500

cgtgttacca tctaccatca agaaggaagc cagcgaggat gccagtgccc tgggatcgtc     1560

gtcctacaag aagaagaagg aggcccagga caaagccaac agtgccagct ctcacaactg     1620

gaacacacta ttcatggggc cgaatgccgt ggccgatgcc atcgcacaga agtacaacgc     1680

caccaagagt caagtgtttg accacgagac caagggcagc gtggccgtgc gcgtggctct     1740

gggggaaacc cagctcgtcc aggaagtgcg gcgttttctc atagacaacg gggtcagcct     1800

ggattccttc agccaggctg cagcagagcg aagcaagact gtgattctgg tcaagaacct     1860

cccggcaggc accctggcgg cccagctgca ggagaccttc ggccattttg gcagcctggg     1920

ccgcgtgctg ctgccagagg gcggaatcac tgccatcgtg gagttcctgg agcccctgga     1980

ggcccgcaag gccttcaggc atctggccta ttccaagttc catcatgtcc ccctctatct     2040

ggagtgggct ccagttggcg tcttctccag cacagcccca cagaagaaaa agctccaaga     2100

cacaccttca gaacccatgg aaaaggaccc agcagagcca gaaacagtgc ctgatggcga     2160

aaccccagaa gatgaaaatc caacagagga aggagcagac aactcttcag caaagatgga     2220

agaggaggag gaggaagagg aagaagaaga agagagcctc ccaggatgta ctctgtttat     2280

taagaatctc aattttgaca caacagaaga gaagctgaag gaagtgtttt caaaagtggg     2340

gacagtgaag agctgctcca tctccaagaa gaagaacaaa gcaggagtgc tcctttccat     2400

ggggtttgga tttgtggaat acaggaagcc ggagcaagcc cagaaagctc tcaagcagct     2460

ccagggtcac gtcgtggacg gccacaagct ggaagtgagg atctcggaac gagccactaa     2520

gccagccgtg acattggctc ggaagaaaca agttcccaga aagcagacca cctccaagat     2580

cctggtgcgg aacatcccct tccaggccca cagccgggag atccgagagc tcttcagcac     2640

ctttggggag ttgaagacgg tccgcctgcc aaagaagatg actgggacag gcacacacag     2700

aggcttcggc tttgtggact tcctcaccaa gcaggatgcg aagagagcct tcaacgccct     2760

gtgtcacagc acccacttgt acgggcggag gctggtgctg gagtgggccg actccgaggt     2820

gaccctgcag gccctgcggc ggaagacggc cgctcacttt cacgagcccc cgaagaaaaa     2880

gcggtctgtg gtgttggacg agatcctgga gcagctggaa ggcagtgaca gcgacagcga     2940

ggagcagacc cttcagctgt gagctggcac cgagagggct ggagtgcagt ggcgtgatct     3000

gggctcacct ccctggttca agcgattgtc ccgcctcagc ctcccaaggc tgggattaca     3060

ggtatgcacc accacgcccg gctaattttg tatttttcat agagactggg tttcaccatg     3120

tagaccaggc tggtctcgaa ttcctgacct caagtgatcc acctacctcg gcctcccaaa     3180

gtgtggggat tacgggtgtg agccaccacg cccggctaat tttttgtatt tttagtagac     3240

agggtttcac catgtgggcc aggctggtct tgaactccca acctcaagtg atccacccac     3300

cttgttctcc caaagtgctg agattacagg tgtgagccac catgcccagc ctgttcctaa     3360

ccctttcaac tggggggtct caagtgggtg aggactccat ggccacggca gcagaactgt     3420

ctcttctgaa aaccagactc cggggcccct gggtcagcac ctctaggtca ttccacagac     3480

ttacacagtt taaagaaaga gccagcgaac atggggtgat cctggggtgc cactgggatc     3540

ccaagccagg cccggaggtc tgcctgtttc gtccccagaa acttgagctg gcatcctccg     3600

ctggtttgca ctgggcacgg ggactggaga gccaccaggc cactgagcgc agcatgctat     3660

cacttctcag gaagttgtga gggtgaggag aatagccggg cccactctgc agaggggagg     3720

aacaggcaca ggctagaggc acgggctgat agagtgagtc ctctccctca ttcattcatt     3780

cattcattca ttcatccatc agacacctgc tgggcatctg ctgtgtgcga gacactgtgc     3840

tgggtgcccc agacacaaga cagaaactcg ggtcgctctg tgtgcctcca cactggcctt     3900

ccctgctgcg tggacgcagg ctctgtctcc taggctttaa gccccatgca tcaggtggaa     3960

gacaatttcc agcagcctct gcccgcttgt ttttcctcct ctccttttcc tgccgccttg     4020

gtcttttttg tcttttgtgc agggccgtct ctcgcagcgc ccgtctgtgc tccgcagcgt     4080

ctaggaaagg attagtgtga gcagagcacg caggctttgg tgaacagagc cgagcttggt     4140

ttcaacatct aattcaattt gttctgccga gattgaaata tgaaatggtt gccagtcaaa     4200

cgttcaaagg acggggaagg gagagtgagc gcatgctgaa atttaaattt taatgaaaat     4260

gactttaacc ctttggtaca ccttgcaaaa tgtaacccat cctcccatcc tgtgaaagcg     4320

gcctctcggg ttagagcttt tccacccact tctcttccac tgagcttcac taataatatg     4380

taatcatttt tttcagccgt cttaataata aaagattaat ag                        4422


<210> 4445
<211> 987
<212> DNA
<213> Homo sapiens

<400> 4445
caacggaccc tacctcttgt agtgattctc ggggccacgg gcaccggcaa atccacgctg       60

gcgttgcagc taggccagcg gctcggcggt gagatcgtca gcgctgactc catgcaggag      120

cttgcaagtt tttgaagaaa caggaatctc tcatagtgaa tttctccatc gtcaacatac      180

ggaagaaggt ggtggtcccc ttggaggtcc tctgaagttc tctaaccctt gcatcctttg      240

gcttcatgct gaccagttct agatgagcgc ttggataaga gggtggatga catgcttgct      300

gctgggctct tggaggaact aagagatttt cacagacgct ataatcagaa gaatgtttcg      360

gaaaatagcc aggactatca acatggtatc ttccaatcaa ttggcttcaa ggaatttcac      420

gagtacctga tcactgaggg aaaatgcaca ctggagacta gtaaccagct tctaaagaaa      480

ggtattgagg ctctgaaaca agtaactaag agatatgccc ggaaacaaaa ccgatgggtt      540

aaaaaccgtt ttttgagcag acctggtccc attgtccccc ctgtctatgg cttagaggta      600

tctgatgtct cgaagtggga agagtctgtt cttgaacctg ctcttgaaat cgtgcaaagt      660

ttcatccagg gccacaagcc tacagccact ccaataaaga tgccatacaa tgaagctgag      720

aacaagagaa gttatcacct gtgtgacctc tgtgatcgaa tcatcattgg ggatcgcgaa      780

tgggcagcgc acataaaatc caaatcccac ttgaaccaac tgaagaaaag aagaagattg      840

gactcagatg ctgtcaacac catagaaagt cagagtgttt ccccagacca taacaaagaa      900

cctaaagaga agggatcccc agggcagaat gatcaagagc tgaaatgcag cgtttaagag      960

acatgtccag tggcctttgg aaaggtg                                          987


<210> 4446
<211> 4233
<212> DNA
<213> Homo sapiens

<400> 4446
ttgtatagta agtttattgt atagtaactt gtaagtatat tcgtaaaagg taaaaccaaa       60

attttactcc tatggtaaaa tttttatata cctagacatt gtagtcactg gaaaatgtgt      120

tattttccct ccaacttaga aaggcaaaat agctgtcata atcaaaaata caggtgcttc      180

ttcaactatg gggagaggga tcatcttgga ataaggagag ttttaggatc ctgccttatt      240

aagagcctgg acatatttat agaggaagtg ttccaggtag gaaatgtggt tttaaaatat      300

gtgcacattc aaaataatga cttacaatat acttgctttg ctaggaaact gaataaaatt      360

acaaaattta ttgaggagaa taaagaaaaa tttacacagc tagatttgga agatgttcaa      420

gttagagaaa agttaaaaca tgccacgagt aaagccaaaa ctggagaaac aacttcaaaa      480

agataaagaa aaggttgaag aatttaaaag tatacctgcc aagagtaaca atatcattaa      540

tgaaacaaca accagaaaca atgccctcga gaaggaaaaa gagaaagaag aaaaaaaatt      600

aaaggaagtt atggatagcc ttaaacagga aacacaaggg cttcagaaag aaaaagaaag      660

tcgagagaaa gaacttatgg gtttcagcaa atcggtaaat gaagcacgtt caaagatgga      720

tgtagcccag tcagaacttg atatctatct cagtcgtcat aatactgcag tgtctcaatt      780

aactaaggct aaggaagctc taattgcagc ttctgagact ctcaaagaaa ggaaagctgc      840

aatcagagat atagaaggaa aactccctca aactgaacaa gaattaaagg agaaagaaaa      900

agaacttcaa aaacttacac aagaagaaac aaactttaaa agtttggttc atgatctctt      960

tcaaaaagtt gaagaagcaa agagctcatt agcaatgaat cgaagtaggg ggaaagtcct     1020

tgatgcaata attcaagaaa aaaaatctgg caggattcca ggaatatatg gaagattggg     1080

ggacttagga gccattgatg aaaaatacga cgtggctata tcatcctgtt gtcatgcact     1140

ggactacatt gttgttgatt ctattgatat agcccaagaa tgtgtaaact tccttaaaag     1200

acaaaatatt ggagttgcaa cctttatagg tttagataag atggctgtat gggcgaaaaa     1260

gatgaccgaa attcaaactc ctgaaaatac tcctcgttta tttgatttag taaaagtaaa     1320

agatgagaaa attcgccaag ctttttattt tgctttacga gataccttag tagctgacaa     1380

cttggatcaa gccacaagag tagcatatca aaaagataga agatggagag tggtaacttt     1440

acagggacaa atcatagaac agtcaggtac aatgactggt ggtggaagca aagtaatgaa     1500

aggaagaatg ggttcctcac ttgttattga aatctctgaa gaagaggtaa acaaaatgga     1560

atcacagttg caaaacgact ctaaaaaagc aatgcaaatc caagaacaga aagtacaact     1620

tgaagaaaga gtagttaagt tacggcatag tgaacgagaa atgaggaaca cactagaaaa     1680

atttactgca agcatccagc gtttaataga gcaagaagaa tatttgaatg tccaagttaa     1740

ggaacttgaa gctaatgtac ttgctacagc ccctgacaaa aaaaagcaga aattgctaga     1800

agaaaacgtt agtgctttca aaacagaata tgatgctgtg gctgagaaag ctggtaaagt     1860

agaagctgag gttaaacgct tacacaatac catcgtagaa atcaataatc ataaactcaa     1920

ggcccaacaa gacaaacttg ataaaataaa taagcaatta gatgaatgtg cttctgctat     1980

tactaaagcc caagtagcaa tcaagactgc tgacagaaac cttcaaaagg cacaagactc     2040

tgtcttgcgt acagagaaag aaataaaaga tactgagaaa gaggtggatg acctaacagc     2100

agagctgaaa agtcttgagg acaaagcagc agaggtcgta aagaatacaa atgctgcaga     2160

ggaatcctta ccagagatcc agaaagaaca tcgcaatctg cttcaagaat taaaagttat     2220

tcaagaaaat gaacatgctc ttcaaaaaga tgcacttagt attaagttga aacttgaaca     2280

aatagatggt cacattgctg aacataattc taaaataaaa tattggcaca aagagatttc     2340

aaaaatatca ctgcatccta tagaagataa tcctattgaa gagatttcgg ttctaagccc     2400

agaggatctt gaagcgatca agaatccaga ttctataaca aatcaaattg cacttttgga     2460

agcccggtgt catgaaatga aaccaaacct cggtgccatc gcagagtata aaaagaagga     2520

agaattgtat ttgcaacggg tagcagaatt ggacaaaatt acttatgaaa gagacagttt     2580

tagacaggca tatgaagatc ttcggaaaca aaggcttaat gaatttatgg caggttttta     2640

tataataaca aataaattaa aggaaaatta ccaaatgctt actttgggag gggacgccga     2700

actcgagctt gtagacagct tggatccttt ctctgaagga atcatgttca gtgttcgacc     2760

acctaagaaa agttggaaaa agatcttcaa cctttcggga ggagagaaaa cacttagttc     2820

attggcttta gtatttgctc ttcaccacta caagcccact cccctttact tcatggatga     2880

gattgatgca gcccttgatt ttaaaaatgt gtccattgtt gcattttata tatatgaaca     2940

aacaaaaaat gcacagttca taataatttc tcttcgaaat aatatgtttg agatttcgga     3000

tagacttatt ggaatttaca agacatacaa cataacaaaa agtgttgctg taaatccaaa     3060

agaaattgca tctaagggac tttgttgaac tttatgctga agattcttca agttgattca     3120

gtgtattact gatttttttc tatttgtaaa ggattatgag ttgtataaaa tacatactcc     3180

ctaaactaga tcatgaaact ggtttctgtt ttatgcagtt gtcatttgta aagtctaata     3240

aaatattctc tataattgct tctagattac aaaaatatga caatcttgta agtagcagac     3300

tatggagaaa aatgagttac ctggagggtc aggtaacttg ccaaactaaa aagtatgtta     3360

gttgaggcaa agtcctaagc aaggttgtgc tatcaaggct cagcatacct tcgtgggcct     3420

ttgatttacc aacactggaa atgcctgcca actaatcttg gatagattct ttaaggcatt     3480

ccacttagct tgccagttga gacaatcacc acagttatta cccaaatact atgaacatat     3540

ttttgtaaac cagtcattct gaattatagt gatgagaatt taaatatatg cttttctaga     3600

atttgatgtt tgaccattta tgacttaatt accagagagc cagtaaatta ggacagtgtt     3660

tcaacaagcc taggctatct cgtaagttga aaaatatccc actatagttg cttcatgagt     3720

atgaagtaag atggcctctg atttacactg gttcaattta caaattttca actttatgat     3780

aggtttatcc gggtactaaa tgcatttcaa cttgatagtt tcaacttatg ataggtttac     3840

caggatgtag tcccactgtt gaggagcatc tatttagggg ttaattactt tagtaataag     3900

tggaaagtaa gataccttga gtaatgtttg cctataaaat tgtcagcgta tttttacact     3960

attggctcaa gaatgttata atgctaaggg acataagttg gcaaccactt ggtttttgga     4020

aggactttcg gtattgtatt agaagtctgc cctagctgtt aaatttctgg gtatttatcc     4080

taaggaatta attaaagagt taattgttcc tttcttcagt gggccattgt tttagatatt     4140

taaaaaatcc aacagtttct atcataatgt aactgtaaaa atgtaaacac attattagca     4200

tggactttta aataaagatt taaagaaagc aag                                  4233


<210> 4447
<211> 2542
<212> DNA
<213> Homo sapiens

<400> 4447
atgtttctta ccagaccgaa ggtctgtgtt gaccttaacc ggagagtgac tttgtatgga       60

gtgtttacaa tccacttttc tccaaatgtg ccatcacgct gtctgttgct tgaactcctg      120

gatgtcagtg tttcggaatt gctcttatat tccagtcacc agggttgttc catgtggatg      180

atacagcatt gtgcccgaga tgttttggag gcccttgctt ttcttcatca tgagggctat      240

gtccatgcgg acctcaaacc acgtaacata ttgtggagtg cagagaatga atgttttaaa      300

ctcattgact ttggacttag cttcaaagaa ggcaatcagg atgtaaagta tattcagaca      360

gacgggtatc gggctccaga agcagaattg caaaattgct tggcccaggc tggcctgcag      420

agtgatacag aatgtacctc agctgttgat ctgtggagcc taggaatcat tttactggaa      480

atgttctcag gaatgaaact gaaacataca gtcagatctc aggaatggaa ggcaaacagt      540

tctgctatta ttgatcacat atttgccagt aaagcagtgg tgaatgccgc aattccagcc      600

tatcacctaa gagaccttat caaaagcatg cttcatgatg atccaagcag aagaattcct      660

gctgaaatgg cattgtgcag cccattcttt agcattcctt ttgcccctca tattgaagat      720

ctggtcatgc ttcccactcc agtgctaaga ctgctgaatg tgctggatga tgattatctt      780

gagaatgaag aggaatatga agatgttgta gaagatgtaa aagaggagtg tcaaaaatat      840

ggaccagtgg tatctctact tgttccaaag gaaaatcctg gcagaggaca agtctttgtt      900

gagtatgcaa atgctggtga ttccaaagct gcgcagaaat tactgactgg aaggatgttt      960

gatgggaagt ttgttgtggc tacattctac ccgctgagtg cctacaagag gggatatctg     1020

tatcaaacct tgctttaatc agtaacctaa ggactgtttc ctttttctcc tcttccattt     1080

cttgggttat tccacatatg aatgcaggac taccccctta ccattttaag aaggtacttt     1140

atacatttat ttaatcctac taatgtgcag ccattgccca agcagtgact gcgttgcata     1200

catttggcac tgagtaggac aagacctctc agctatacat tgaggggttt tagagcatcc     1260

atgtgggcaa cccttttttg tgcgggagag caggtgttgc tcttcagtat gtagcctaaa     1320

aaaatcttaa ttatttcatg gatcatgaag caaggatgaa taatatcatg tcttggtaaa     1380

tactaacaaa tttgttaggt ttggtgacat catttacaga ttatttcttt atgttgtcca     1440

gtggttcttc cttattgttg atatccataa gctggcactg gatgctctca gtaatgttaa     1500

gtaattgtca agcagcagtt acctactgtg ttcttaacac tgagttgtga attttttctt     1560

aaagcagtac tgtagtactg aatattcctt taaaggaact gcagtgagcc tatctaagtt     1620

tttttaaatt aaggctttta aaatagaaag ctgatgcttg atcttgcaca atttttatgt     1680

ctagtatgta tgcttgagtg aatgtgcgag tatgaatgat tagagaaaat ttgagtcagt     1740

gtactttata gtgtgaatcc tgtgagctaa tacagtctat acttatttct tccctacctg     1800

tttcacatcc gtaagattta agatatacat tttttgagag gtagtctgtc tgatacaatg     1860

taaatgacaa aacataattc ctgagaggcc cagaacaaac tggagtctag cctggagtta     1920

aattgagact tctaaaatga ttggaacaaa gactaagttg tgccagatgt aaatcaaccc     1980

ctcttttagt ttactttaga ctttgtatta gctcatcttt tttgtagtaa atctatagtt     2040

ttaaggtttc tcaagatgtg gctctaccta ctatgatgaa aattgaagtg ggtcaaaaga     2100

attagatgta cagtgaaggg aaaagaaaaa aaatgggcga agagagggtg gaaaataaaa     2160

ggattctttt ttcttccttt ctgtttctcg tatccctgct ccctttttcc tccccttccc     2220

tcattctttg cctctatcct tagctgaaga caaactagag gagcagcatc ccaggtagtt     2280

tggcttttga ctgcaaggta gttaagaaag gtgtagatat aatgaggtag aagtagaaag     2340

gaagaaaaac tcaaagaatt cttaaaagga ttcatagcaa cataatgtgt ccctgagtag     2400

aggatgctgc tatgcgtgag ttcatggaca caagttgatt acatggtttt tagaattata     2460

attatggatt cttcttattt catggtaggt tgtctttaaa gatataaaaa ttaggatgcc     2520

tttatgaagc actgattata cc                                              2542


<210> 4448
<211> 1217
<212> DNA
<213> Homo sapiens

<400> 4448
gatgcgctcg agtgtgggcg gggactgagg gaagaagtga aaatcggact gccaggcgac       60

agttcctccg tttgaaatct cgccggctcc tgagcgggcc accgggcccg ggctgggggt      120

ctggcgggag aaataacttt atttggactg agagctggag aatgagaata ggacctgaga      180

gtatattggg ctaaggagga gagaaattct tgaatttgcc cgggagattg gtattgatcc      240

catcaaggaa ccagaactga tgtggctggc gcgagagggc atcgtggccc cactgcctgg      300

agagtggaaa ccatgccagg acatcacagg tgacatttac tatttcaact tcgccaacgg      360

gcagtctatg tgggaccatc catgtgacga acactatcgg agcttggtga tccaagagcg      420

ggcaaagctg tcaacttctg gggccattaa gaagaagaaa aaaaaaaagg aaaagaaaga      480

caagaaggac agagaccccc ccaaaagttc gctggaaacg cagcctgagg agggacttct      540

gcctccttca tcctttctct gcagcttgtc tcctccgtca gcacctgggc ttgctgatct      600

ggacctagat caagagatgc aggctataag tgagggatcc tataacaaag gaaagagccc      660

aggcatgctg ggtgacactc cctggcgttt catgggtgcc cttcccagaa agctgcagcc      720

actctccaaa ggccaacctt cccaaatcca ccaggtcttt gctgacatgg agaaaatctt      780

aggcagggcc ccagcccaat gcaggagaga attaggtgat cagcagggtc tggagaaact      840

ccagaaggcg acagagaaaa tctacctggg gttttcagat cctgaaacag aagagctgga      900

aatgagaagc aggcagcaga aactgggcac tccagcccct cagaacactg ggcttctcca      960

aaatatgcag gatgtggtag aaagcaggaa ccaggcctct gtccactcaa agctttctga     1020

agccatcaaa ggcctgccac tgaaagggga gcagcacagc cacagcttag ccaaactgag     1080

ccccactggc cctggagggg acaagggcca aagccccatt cccatgtgga tctgctgcag     1140

gctcagagcc agcaactgca gaaacacttc agcagcctgg aggctgaagc tcaaaagaag     1200

cagcacctgt tgagaga                                                    1217


<210> 4449
<211> 506
<212> DNA
<213> Homo sapiens

<400> 4449
acagcgcgcg tccaagtgga gaacaaagtg acccccagaa cttctccaac tcctcccggc       60

gttcccgcga gggccacgcg ccgagggtag cggagggcgg cgcgcgaccg gccccaccga      120

gcccggcgcg cgacccgagg gctctgtgta tgaatgacaa ggataccttc agccagctca      180

ttctggatga atgaatgatt acactaagtg tcctccacat tcctctgtgg gctcacttca      240

tggactcact ttgcgtgctt gttaaatgtg ctgtgttgct cccaagacca tgtaaagcct      300

actgaccact aacctccctc acagcagaaa ctagacgtca ggttaaaatg ggcaactccg      360

acagtcagta cacccttcaa ggatctaaaa atcatagcaa tactattact ggtgctaagc      420

aaattccttg ctccctgaaa atacgtggca ttcatgcaaa agaggaaaag tcattgcatg      480

gatggggtca cggaagcaac ggagca                                           506


<210> 4450
<211> 1542
<212> DNA
<213> Homo sapiens

<400> 4450
ggtgcgagtg gggaagctgc taacccgacc cggattggcg ctgaggtggc ccgtggggca       60

gggcagatga ttctggacca gatgaagcct gaggagcctt ccagctctaa gatagcagga      120

taggagactt ctaagattgg agctgcagaa gacttgccag cccaccagca caatgtcagg      180

aagccataca cctgcctgtg gccctttctc agccctgact ccgagcatat ggccccagga      240

gatcttggcc aagtacacgc agaaggaaga gtcagcagag caaccagagt tctactacga      300

tgagtttggt ttccgtgtgt acaaggaaga aggtgatgag cctggctcca gtctgctggc      360

gaactcccct ctgatggagg atgctccagg ctgcggtggc aggcccacct ggagttcacc      420

cataaccacg atgtggggga tctcacctgg gacaagattg ccgtctccct accccgctct      480

gagaagctcc gctccctggt gctggccggc atcccacatg gcatgaggcc acagctgtgg      540

atgcggctct ctggggccct gcagaagaag aggaactctg agctgtccta ccgcgagatt      600

gtgaagaaca gctccaacga tgagaccatc gctgccaagc agatcgagaa ggacctgctc      660

cgcaccatgc ccagcaacgc ctgcttcgcc agcatgggta gcatcggggt gccccgcctg      720

cgcagggtgc tccgggccct ggcctggctc tacccagaga tcggctactg ccagggcacc      780

ggcatggtgg ccgcctgcct cctgctgttc ctggaggagg aggacgcctt ctggatgatg      840

tctgccatca tcgaggacct gctccccgcc tcctacttca gcaccaccct gctgggtgtc      900

cagactgacc agcgggtcct gcgccacctc attgtccagt acctgcctcg cctggacaag      960

ctgctccagg agcatgacat tgagctgtcc ctgatcacac tgcactggtt cctcacggcc     1020

ttcgccagcg tggtggacat caagctgctc ctgcgcatct gggacctgtt tttctacgag     1080

ggctcccggg tgctgttcca gctcacgctg ggcatgctgc acctcaagga ggaagagctg     1140

atccagtcag agaactcggc ctccatcttc aacacgctat cggatatccc gtcgcagatg     1200

gaggacgcgg agctgcttct gggggtggcc atgcggctgg ccggctccct caccgatgtg     1260

gccgtggaga ctcagcgccg caagcacctg gcctatctca ttgcagacca gggccagctc     1320

ctgggggccg gcaccctcac caacctctct caggtggccc aggatggggg gccgcacctt     1380

gacccacagc acacggggag gaggggtcac cttgaagttc agagcgcggg ggctgcggaa     1440

aacaaaccag cccttcctgc tctgcccccc agcctggccc agtcagacca cagctgtggg     1500

gtgatccagg cctcctcagg ctttgtgcac ctcaggttct ga                        1542


<210> 4451
<211> 367
<212> DNA
<213> Homo sapiens

<400> 4451
caaccctgcg ctgaatgctg cgaggaacaa aggagatgga caacatgtct cccaggctga       60

gagccttcct ctccgaaccc attggagaaa aggatgtctg ctgggtggat ggcatcagcc      120

atgagctcgc gatcaatttg gtcaccaaag gtatcaataa ggcctacatc ctgctgggac      180

aattccttct gatgcacaag aatgaagccg agtttcagag gtggctcatt tgctgttttg      240

gtgccactga gtgtgaggcc cagcagactt ctcactgcct caaggagtgg tgtgcctgct      300

tcctgtagac acaaacctca ttgctgcccc ccaccaccct ctggggaaaa tgacgccttc      360

tccacct                                                                367


<210> 4452
<211> 2178
<212> DNA
<213> Homo sapiens

<400> 4452
cgggctttct ccggtcgctg ccgccaccac cgttgcttcg cgggctggga ggcccggggt       60

ccccgggcga acagaggctg cgggtgggag ccttcgcggg cgctgcagag cgggccgggg      120

gaggccggga tggagccccg cggagtggac tgacgccgca ggggcgagct agccggctcc      180

gcgcctctcc gcgggatcca gacgcctcct ggggctgctg gcggagggtc tgaggcggcg      240

cggccatggc tcacctccgg ggatttgcca accagcactc tcgagtggac cctgaggagc      300

tcttcaccaa gctcgaccgc attggcaagg gctcgtttgg ggaggtctac aagggcatcg      360

ataaccacac aaaggaggtg gtggccatca agatcatcga cctggaggag gccgaggatg      420

agatcgagga catccagcag gagatcactg tcctcagtca gtgcgacagc ccctacatca      480

cccgctactt tggctcctac ctaaagagca ccaagctatg gatcatcatg gagtacctgg      540

gcggcggctc agcactggac ttgcttaaac caggtcccct ggaggagaca tacattgcca      600

cgatcctgcg ggagattctg aagggcctgg attatctgca ctccgaacgc aagatccacc      660

gagacatcaa agctgccaac gtgctactct cggagcaggg tgacgtgaag ctggcggact      720

ttggggtagc agggcagctc acagacacgc agattaagag gaacacattc gtgggcaccc      780

ccttctggat ggcacctgag gtcatcaagc agtcggccta cgacttcaag gctgacatct      840

ggtccctggg gatcacagcc atcgagctgg ccaaggggga gcctccaaac tctgacctcc      900

accccatgcg cgtcctgttc ctgattccca agaacagccc acccacactg gagggccagc      960

acagcaagcc cttcaaggag ttcgtggagg cctgcctcaa caaagacccc cgattccggc     1020

ccacggccaa ggagctcctg aagcacaagt tcatcacacg ctacaccaag aagacctcct     1080

tcctcacgga gctcatcgac cgctataagc gctggaagtc agaggggcat ggcgaggagt     1140

ccagctctga ggactctgac attgatggcg aggcggagga cggggagcag ggccccatct     1200

ggacgttccc ccctaccatc cggccgagtc cacacagcaa gcttcacaag gggacggccc     1260

tgcacagttc acagaagcct gcggagcccg tcaagaggca gccgaggtcc cagtgcctgt     1320

ccacgctggt ccggcccgtc ttcggagagg tcttttcaca gctcaaagag aagcacaagc     1380

agagcggcgg gagcgtgggt gcgctggagg agctggagaa cgccttcagc ctggccgagg     1440

agtcctgccc cggcatctca gacaagctga tggtgcacct ggtggagcga gtgcagaggt     1500

tttcacacaa cagaaaccac ctgacatcca cccgctgaag cgcactgctg ttcagatagg     1560

ggacggaagg tcgtttgttt ttgttctgag ctccataaga actgtgctga cttggaaggt     1620

gccctgtgct atgtcgtgcc tgcagggaca cgtcggatcc cgtgggcctc acatgccagg     1680

tcaccaggtc accgtctcct tccacccctg cagtgtgctg ttgtgcacgt cagggacgct     1740

gttctctatg cccactgccc tcctccctct cctggcccag cagtattgct cacgggggct     1800

ccagccgccg gcgtggccct catgagctac gcctgggtct tctgcagact catgcagccc     1860

tatggccgct cagaccaagg cgcagagcaa ctatcagggc agctctgcct cctcctccca     1920

tgaggtgggg agaggcaaca gggcagcccc cagaggagtg tcctggccgc tgtcctcccg     1980

gggcccatga tggccataga tttgccttgt ggtgttggat caggtactgt gtctgctcat     2040

aagtacttgt gtcatccaga atgttttgtt ttttaagaaa attgaattac ttgtttcctg     2100

aaatattctg aggttaatat gttagttttc atagaacatt gagaggcccc tgccactttc     2160

aataaagacc tgacttgg                                                   2178


<210> 4453
<211> 1802
<212> DNA
<213> Homo sapiens

<400> 4453
caagaagaaa gaggaggccg gcttttcagc tagcatcatg gcgtggccgt gcatcacgag       60

ggcctggggc acgagcagac gccgctgccc gcggcccagg cccaggtcca ggccaccggc      120

cccgaggctg gcagggggcg cgccgcggcg gacgccctca accggcaaat ccgcgaggag      180

gtggcgagtg cagtgagcag ctcctacagg aatgaattca gggcatggac ggacatcaag      240

cctgtgaaac caataaaggc caagccccag tacaagcccc cagatgataa gatggttcat      300

gagaccagct acagtgctca gttcaaagga gaggccagca agccaacaac agctgacaat      360

aaggtcattg atcgcagaag aatacgcagc ctctacagcg aacccttcaa ggaaccccca      420

aaggtggaaa aacctagtgt tcagagttcc aaaccaaaaa agacctcagc gagccataag      480

cccacgagga aggccaaaga caagcaggcg gtgtcaggcc aggctgccaa gaaaaagagc      540

gcggagggcc cgagtaccac caagccagac gacaaggagc aaagcaaaga gatgaacaat      600

aaactggctg aggcgaaaga gagcctggct caacccgtca gtgattcaag taagactcaa      660

ggtcctgtag ccacagagcc agacaaggat caaggttctg tggtcccagg ccttctgaaa      720

ggtcaaggtc ctatggtgca agagcctctg aagaagcaag gttctgtggt cccagggcct      780

ccaaaggatc taggtcccat gatcccatta ccagtcaagg atcaagatca cacggtccct      840

gagcctttaa agaatgaaag ccctgttatc tcagcaccag tcaaggacca aggtccctcg      900

gtcccagttc ctccaaagaa tcaaagtcct atggttccag caaaagttaa ggatcaaggc      960

tctgtggtac cagagtctct aaaggatcaa ggtcctagga ttcctgagcc tgtgaagaat     1020

caagctccta tggtcccagc acctgtcaag gatgaaggtc ccatggtctc agcatctgtc     1080

aaggatcaag gtcccatggt ctcagcacct gtcaaggatc aaggtcccat agtcccagca     1140

cctgtcaagg gtgaaggtcc catagtccca gcacctgtca aggatgaagg tcccatggtc     1200

tcagcaccta tcaaggatca agatcccatg gtcccagagc atccgaagga tgaaagtgcc     1260

atggccacag cacccataaa gaatcaaggt tccatggtct ctgagcctgt aaagaatcaa     1320

ggtttagtgg tctcagggcc agtcaaggat caagatgttg tagtcccaga gcatgcaaag     1380

gttcacgatt ctgcagttgt ggcacctgta aagaatcaag gtcctgtggt ccccgagtcc     1440

gtgaagaatc aagaccccat tctcccagta ctagttaagg atcaaggccc cacagtccta     1500

cagcctccaa agaatcaagg tcgtatagtc cctgaacctc tgaagaatca agttcctata     1560

gtcccagtgc ctctgaagga tcaagatcct ctggtgccag taccagcaaa ggaccaaggt     1620

cctgcagtcc ctgaacctct gaagactcaa ggtcccaggg accctcagct acctactgtc     1680

tcacctctac cccgagtcat gatcccaact gccccccata cggaatacat tgagagctcc     1740

ccttgacact caccccttga cacaccaatg aaggagctga cagtgagagt gctcccctcc     1800

ca                                                                    1802


<210> 4454
<211> 2818
<212> DNA
<213> Homo sapiens

<400> 4454
atggccctgg gtgaagaaaa ggcagaagcg gaagcatctg aagacacaaa ggcccagtcc       60

tatgggagag ggagctgcag ggagcagccc ccacgcctgg aagctgaggg agggctcatc      120

tcccctgtat ggggggcaga agggatacct gcccctactt gctggattgg gactgaccct      180

ggcggcccct ctagagccca ccagccacag gccagtgatg ccaacagaga gcccgtagct      240

gagaggtctg agcctgcact cagtggcctg cctcctgcca ccatggggtc tggagacctt      300

ctgctctccg gggaaagcca ggtggagaag accaagcttt cttcctccga ggagttccct      360

cagactctga gccttcccag aacaacaact atttgctcag gacatgatgc tgataccgaa      420

gatgatccat ccctagcaga tttgccccag gcactggacc tcagccagca gcctcacagc      480

tcaggtctct cttgcctgtc acagtggaag tccgtgctga gcccaggttc cgcagctcag      540

ccttccagct gcagcatctc tgcttcctcc acaggcagca gtctccaggg tcaccaggag      600

agggcggagc ctcgtggtgg ttctctggcc aaggtctcct cctccctgga gccggtcgtc      660

ccccaggaac cttcctctgt ggtggggcta ggacctcggc cccagtggtc accacagcct      720

gtgttctctg ggggtgatgc ttctgggcta ggcaggagac gcctctcctt ccaggctgag      780

tactgggcct gtgtgctgcc agattccctg cctccatcac ccgaccgcca ctcccctctc      840

tggaacccaa ataaagagta tgaagatctg cttgactata cttacccact gaggcccggg      900

cctcagctcc caaagcacct tgatagccgt gtgccagctg accctgtcct gcaggactcc      960

ggggtagacc tggatagctt ctctgtctct ccagcaagca ccctcaaatc acctactaat     1020

gtctccccca actgcccacc agcagaggcc actgccctgc cattttctgg gcccagagag     1080

ccaagcctta agcagtggcc ctccagagta ccccagaaac agggtggcat gggcttggca     1140

tcttggagcc aacttgcatc tacccccaga gccccaggca gtagggatgc tcgttgggag     1200

cgcagagagc cagccctgag gggtgcgaag gaccggctga ctataggcaa gcaccttgat     1260

atgggctctc cccagctaag gacacgggac agagggtggc cctcgcccag gccagagagg     1320

gagaagagga ccagccagag tgcccggcgc cctacctgca cagagtctag gtggaaatca     1380

gaagaggaag tggaaagtga tgacgagtat cttgccctcc ccgctcggct gacacaggtt     1440

tctagcctgg tttcgtatct aggatccatt tctaccttgg ttaccctgcc cactggggat     1500

atcaaagggc agagcccctt ggaagtgtca gacagtgatg ggccagcttc cttcccttca     1560

agctccagcc aaagccagct tccccctgga gctgccctcc aaggatctgg ggatcctgag     1620

ggccagaatc cctgtttcct gcgctccttc gtccgtgccc acgactccgc aggggaaggc     1680

agtctgggga gcagccaggc cctcggggtc tcctctggac tgctgaaaac acgcccctcc     1740

ttgccagcta ggttggaccg gtggccattc tcagacccag atgttgaagg gcagcttccc     1800

aggaaaggag gagaacaggg aaaagaatca ctggtgcaat gtgtgaagac attttgctgt     1860

cagctggaag agctgatctg ctggctgtat aatgttgcag atgttactga ccacgggact     1920

gcagccaggt ccaatcttac aagtctcaag tcttctctgc agctttaccg ggtaatatgc     1980

ggtcctggct ctggcttgtt ccctcacaag agtgtggcta aattactcga ttacaaagta     2040

aaatctcaaa taaccaatgt ctggtatgtt atagctcagt tgactattat acctgaaatc     2100

taattagagc ttcacattct taaagcggaa cgctttgtaa aatgcatgaa ttatttccca     2160

ggccaaatgg agcttgaaga tacaatatat ttatctcaaa tcaaaaatac tttaggtttt     2220

gggctggcag gtgcagtggg acaagtcttt tatcccagct actctggaag ctgagacagg     2280

aagattgctt gagcccagga gttcgagtac agcctgagca acatagcaag accccccccc     2340

ctcaaaaaaa agttttttct taattaaaaa caaaaatact ttagggtgat ttgcaatata     2400

attttccaaa tgtctcaggg attataaata cagacttgca ctattatgac gcctctagtt     2460

atgtatggct attgaagtaa aattaaagac tcagattttt ttatttgcac tagccacatt     2520

ctgcatgttc aaccatcaca tttgtctagt ggctaccacg tagaacagtg cagatgtaga     2580

acacttccat caccacataa agtcctattg gactgcacca ctatttaaag atctgagctg     2640

aaattgtact gactccagaa tctacaatag ggcattttga tggtatttaa atagaaatct     2700

aggccaggca ccttggctca cactattaat cccagcactt tgggatgctg aggctggagg     2760

atcgcttgag cccgggagtt ccagaccagc ctgggcaata tagtgagacc tcgtctct       2818


<210> 4455
<211> 1942
<212> DNA
<213> Homo sapiens

<400> 4455
agcgtccagg acagcccagg ctcagtcatg aaaagctatg tgtcagagac catggcgagc       60

ccagggaaag acaattatcg aatgaagagc tataagaaca atgctctaaa ccctgaagaa      120

atgagacgaa gaagagagga agagggcatt cagctccgga agcagaagcg agagcaacaa      180

ctttttaaac ggagaaatgt ggagctgatt aatgaagaag ctgccatgtt cgatagtctt      240

ctcatggact cttatgtgag ctctaccact ggggagagtg tgatcacaag agagatggtg      300

gagatgctct tttctgatga ttctgacctg cagttagcaa ccacacagaa attccggaaa      360

ctgctctcca aagagcctag tcctccaata gatgaagtta tcaacactcc aagagtggtg      420

gatcggttcg tggagtttct gaagaggaat gagaattgta cattacagtt tgaagctgcc      480

tgggctctaa cgaatattgc ctctggaacc tctcagcaga ccaaaattgt cattgaagca      540

ggggctgtcc ccatttttat agagctgctt aattcagact ttgaggatgt tcaggaacag      600

gcagtctggg cactgggaaa catagctgga gatagctctg tttgccgaga ttacgtcttg      660

aactgttcca tccttaatcc tttgttaaca ctccttacca agtccacacg actgacgatg      720

acacggaatg cagtctgggc cctgtcaaat ctctgccgag ggaaaaaccc acccccagag      780

tttgcaaagg tctctccttg tttgcctgta ctgtctcgcc tactcttcag cagcgactcg      840

gacttgctgg cagatgcttg ctgggccctt tcttatctgt ctgatggccc caatgagaag      900

atccaggcag tcatagactc cggagtctgc cggagattgg tagagctgct gatgcacaat      960

gattacaaag tggcttctcc tgccctgaga gccgtgggta acatcgtcac tggggatgac     1020

atccagaccc aggtcattct taactgttca gccctacctt gccttctcca cttgttgagc     1080

agtcccaagg agtcaatccg gaaggaagct tgctggacta tttcaaatat tactgctggc     1140

aacagggctc aaatacaggc tgttatagat gcaaatatct tccctgtgtt gatcgaaatc     1200

cttcagaaag cagagtttcg tacaaggaaa gaggcagcct gggccatcac caatgccaca     1260

tcaggaggaa cccctgagca gatcaggtac ctggtctcac tgggctgcat caaaccccta     1320

tgtgacttgc tgactgtaat ggattcgaag attgtgcaag tggccctcaa tggactggag     1380

aacatcctgc ggcttggaga gcaagagggc aagcgcagtg gctcaggggt caatccttat     1440

tgtggcctca tagaggaagc ctatggcttg gataaaattg agtttctcca gagccacgag     1500

aaccaggaga tctaccagaa ggccttcgac ctcattgagc actactttgg tgtagaagac     1560

gatgatagca gcctggctcc ccaagtcgat gaaacgcaac agcagttcat cttccagcag     1620

cctgaggccc ccatggaggg cttccagcta taatatctgc ctccagggag gggaggggat     1680

gggaagcacc accagccagc ggaagagcag ccctctggtg ggcgggaaac cagtgtcccc     1740

accatcagcc accacacacc tctgctgccc tggagactgt gctcttgacc tgctccgccc     1800

ccttccctgg agggagcacc ctctggacag acagaaccat ctgaggctca cctttgggtt     1860

ttgtgacaag aaggggacgt gttgggtttt tcttccttac actatatttt ggctgcacac     1920

atgtctttaa cccaggagcc ca                                              1942


<210> 4456
<211> 1975
<212> DNA
<213> Homo sapiens

<400> 4456
ctcgcgggtc cgggagcgcg gcggagacga tgcctgagat cagagtcacg cccttgggtg       60

cctgccctgt gctgtcctgg aacctggtcc ttccaccggg cagggggtcg agggcacctt      120

ccagcacaga caccaggacg ggattccatg tcctccccca tggcgggccg gccaggacgt      180

gggccgaagc tgcatcctgg tctccattgc gggcaagaat gtcatgctgg actgtggaat      240

gcacatgggc ttcaatgacg accgacgctt ccctgacttc tcctacatca cccagaacgg      300

ccgcctaaca gacttcctgg actgtgtgat cattagccac ttccacctgg accactgcgg      360

ggcactcccc tacttcagcg agatggtggg ctacgacggg cccatctaca tgactcaccc      420

cacccaggcc atctgcccca tcttgctgga ggactaccgc aagatcgccg tagacaagaa      480

gggcgaggcc aacttcttca cctcccagat gatcaaagac tgcatgaaga aggtggtggc      540

tgtccacctc caccagacgg tccaggtaga tgatgagctg gagatcaagg cctactatgc      600

aggccacgtg ctgggggcag ccatgttcca gattaaagtg ggctcagagt ctgtggtcta      660

cacgggtgat tataacatga ccccagaccg acacttagga gctgcctgga ttgacaagtg      720

ccgccccaac ctgctcatca cagagtccac gtacgccacg accatccgtg actccaagcg      780

ctgccgggag cgagacttcc tgaagaaagt ccacgagacc gtggagcgtg gtgggaaggt      840

gctgatacct gtgttcgcgc tgggccgcgc ccaggagctc tgcatcctcc tggagacctt      900

ctgggagcgc atgaacctga aggtgcccat ctacttctcc acggggctga ccgagaaggc      960

caaccactac tacaagctgt tcatcccctg gaccaaccag aagatccgca agactttcgt     1020

gcagaggaac atgtttgagt tcaagcacat caaggccttc gaccgggctt ttgctgacaa     1080

cccaggaccg atggttgtgt ttgccacgcc aggaatgctg cacgctgggc agtccctgca     1140

gatcttccgg aaatgggccg gaaacgaaaa gaacatggtc atcatgcccg gctactgcgt     1200

gcagggcacc gtcggccaca agatcctcag cgggcagcgg aagctcgaga tggaggggcg     1260

gcaggtgctg gaggtcaaga tgcaggtgga gtacatgtca ttcagcgcac acgcggacgc     1320

caagggcatc atgcagctgg tgggccaggc agagccggag agcgtgctgc tggtgcatgg     1380

cgaggccaag aagatggagt tcctgaagca gaagatcgag caggagctcc gggtcaactg     1440

ctacatgccg gccaatggcg agacggtgac gctgcccaca agccccagca tccccgtagg     1500

catctcgctg gggctgctga agcgggagat ggcgcagggg ctgctccctg aggccaagaa     1560

gcctcggctc ctgcacggca ccctgatcat gaaggacagc aacttccggc tggtgtcctc     1620

agagcaagcc ctcaaagagc tgggtctggc tgagcaccag ctgcgcttca cctgccgcgt     1680

gcacctgcat gacacacgca aggagcagga gacggcattg cgcgtctaca gccacctcaa     1740

gagcgtcctg aaggaccact gtgtgcagca cctcccagac ggctctgtga ctgtggagtc     1800

cgtcctcctc caggccgccg ccccttctga ggacccaggc accaaggtgc tgctggtctc     1860

ctggacctac caggacgagg agctggggag cttcctcaca tctctgctga agaagggcct     1920

cccccaggcc cccagctgag gccggcaact cacccagccg ccacctctgc cctct          1975


<210> 4457
<211> 2579
<212> DNA
<213> Homo sapiens

<400> 4457
atggaggccg cggcggtgac ggtcacccgg tcggctacac ggcggcggcg gcggcagctg       60

caggggctgg cggccccgga ggcggggacg caggaggagc aggaggatca ggagccgcgg      120

ccgcggcggc ggcggccggg aaggagcatc aaagatgaag aagaagagac agtctttcga      180

gaggtggtca gtttttcccc ggaccccctg ccagttagat attatgacaa ggacaccacc      240

aaaccaatca gcttttactt gtcttcgctg gaggagctct tggcgtggaa gccccgcttg      300

gaggatggct ttaatgtggc cctggagccc ctggcgtgtc gccagccccc tctgagcagc      360

cagaggcccc ggactttgtt gtgtcatgac atgatgggcg ggtacctgga tgacaggttc      420

attcagggct cggtggtgca gactccctat gctttctacc actggcagtg catcgacgtc      480

tttgtgtact tcagccacca caccgtcacc attcccccag tgggctggac caacactgcc      540

cacaggcatg gggtctgcgt gctggggact ttcatcacgg agtggaatga agggggaagg      600

ctctgtgaag ccttcctggc cggggatgag cgctcgtacc aggcagtggc tgaccggctg      660

gtccagatca ctcagttttt tcgttttgat ggctggctga tcaacatcga gaactcgctg      720

agtctggccg ctgtggggaa catgcctcct ttcctgcggt acctcaccac acagctgcac      780

cggcaggtcc cagggggcct ggtgctctgg tatgacagcg tggtgcaaag tgggcagctc      840

aaatggcaag acgaactcaa ccagcacaac agggtcttct ttgattcctg cgacggcttc      900

ttcactaact ataactggcg ggaggagcac ttggagcgga tgctggggca ggctggggag      960

cgccgggctg atgtgtacgt gggcgtggat gtgtttgctc gagggaacgt ggtcggaggc     1020

cgattcgaca cagacaagtc gttggagctg atccgaaagc atggcttctc cgtggctttg     1080

tttgcccccg gctgggtgta tgagtgtctg gagaagaagg atttcttcca gaaccaggac     1140

aagttctggg gccgactgga gcgttatctg cccacacata gcatctgctc cttgcctttc     1200

gtcacgtcct tctgcctggg catgggtgca cggagggtct gctatggcca ggaagaggcg     1260

gtagggccct ggtaccacct gagcgcccag gagatccagc ccttgtttgg agaacacagg     1320

ctgggagggg atggccgggg ctgggtgagg acgcactgct gcctggagga tgcctggcac     1380

ggaggcagct ccctgctcgt ccggggtgtg atcccaccgg aggttggaaa tgtggctgtg     1440

aggttatttt ccctgcaggc cccagtgcca cccaagattt acctgtccat ggtgtataag     1500

cttgaggggc ccacggacgt cacagttgct ttggagctga ccacagggga tgccggcagc     1560

tgccacatcg gtggcatctc agtgttgaac gcagaaacaa gctcaagaca cagcctccga     1620

cccctccggg tgccccccac caagctggcc agatgggtgg gccgctgcgg ccggcagctg     1680

agtgggggct gggtccagca ctgctacgag gtgagcctgc gtgggtgcct gctgctagac     1740

ctcctcgttt gcttctcacg gccgccgggt agtcgggagg aggagagctt cacctgtcgg     1800

cttggagaga tccaggtggt ggacgctgcc agcctgctgg cccctctgcc ccaggtgcag     1860

gccgtcacca tctctcacat ccgctggcag ccatccgcct ctgagcggga ggggccccct     1920

gctctgctcc agctcagctg caccctgcac tggtccttcc tcctctcaca agtccgttgc     1980

ttccgaatcc actgctgggg agggatgagt gatgactctc cgggcaggga gctgccgagg     2040

ccagagatgc ccatgttcct ggggttggct tttgccaccc agtaccggat agtggacctg     2100

ctggtggaag ccgccgggcc cggccaggat cgtcgcatgg aatttctggt ggagcctgtc     2160

cccaaggaag ggttccgggt acctcaggcc gagtggggca gggcagttct gctttattca     2220

gcccctgcat gagcggatgc taaggccggg tggtctcctg gcctcgggct gaggcctctt     2280

cccggctgtc tgcccctggc ctgcgctgga cctgctaagt gcccacagtg gcagcgaggt     2340

cccggtcccg gggctggggt gggagacccc gggctgagtg ctgtggcttt ctggtggggg     2400

gcgatggaaa caggaaacca agcagtggga tcgcagcgtt ggtcactgcg aggcgagtgg     2460

cgggctttct gtttctgcct tgtccctccc cacggtacct ggttcccagg tgaaaatgaa     2520

aggaggggag aagttgagaa cagaacattc cataaaggat atttcctaat aggctgcaa      2579


<210> 4458
<211> 2449
<212> DNA
<213> Homo sapiens

<400> 4458
tgagggcgga agggacaggc ataggaggga ctctgtggga ggcatttggg gttggctttc       60

ctaggcccct ggcccacctc caccttggct ttggagaagg ggagccgcta caggggatgg      120

cagctgggaa aggccccctg gccaccccca gcaaccccac tgctggcttc tgtgtcaggg      180

cccgccgaaa cccaggccca ctcttcctag aggcctgtca gcagccacta gggccaggga      240

ctgtgggtga ggccactcgg accctgcccc cagtctgtct gggcctgaga agggcctggt      300

gtgcggtggg cttgcagcac tcagtgatgg tcaggccagg caggttatgt gttgccctct      360

cccaccctag cgtccccacc ctccccaggc agactcttcc cagcagcaag cggaagcccg      420

ggcagaggct gctgtcatag gcagaggccc ccgctgatgc cggccctgct tgcccctcac      480

actgccaggt cttcacgtgc tctgtgtgcc aggagacatt ccgccgaagg atggagctgc      540

gggtgcacat ggtgtctcac acaggggaga tgccctacaa ggtcaggctt ggcctgtctc      600

cagggccagg gttgggtggc cccaggatcc ttcctgctga gccctttacg tggggtgctg      660

tcaggcacct ccctcacagt agctgtcagg gagcctgcct tccctgcctt ccctgccttt      720

ccagtgcccc cttatctagg cagggcctgt ctgcagcctc acctccaagg tccttattag      780

gcccttgttt ctttccatgg aggacaggct tggcatcctc tgggcagctg agccctgagg      840

ccctcctttg caccatcctt cacaccagat caggggtcct cccagaatca tctcaccggg      900

gcctccctct agttcctgcc ctatagccca agggtgggtg gcagggtttc atgggtgcag      960

gccgccctgg aggtgactgt gggcctcttt ttcagtgttc ctcctgctcc cagcagttca     1020

tgcagaagaa ggacttgcag agccacatga tcaaacttca tggagccccc aagccccatg     1080

catgccccac ctgtgccaag tgcttcctgt ctcggacaga gctgcagctg catgaagctt     1140

tcaagcaccg tggtgagaag ctgtttgtgt gtgaggagtg tgggcaccgg gcctcgagcc     1200

ggaatggcct gcagatgcac atcaaggcca agcacaggaa tgagaggcca cacgtatgtg     1260

agttctgcag ccacgccttc acccaaaagg ccaatctcaa catgcacctg cgcacacaca     1320

cgggtgagaa gcccttccag tgccacctct gtggcaagac cttccgaacc caaggtgagg     1380

tacgccctgc ccctcccctc gcctccccat cctgaggcca aggccacagg ctgagctctt     1440

gccttgtgcc tgcagccagc ctggacaagc acaaccgcac ccacaccggg gaaaggccct     1500

tcagttgcga gttctgtgaa cagcgcttca ctgagaaggg gcccctcctg aggcacgtgg     1560

ccagccgcca tcaggagggc cggccccact tctgccagat atgcggcaag accttcaaag     1620

gtacctgggc ggccctggga gagccatttc ctgctcatcc gagttggagg gtctctgagg     1680

aggaaacgct cctttcttgc ctgtgaacct cttttgtgcc ccacatggtt agagttgaga     1740

gtggacctgc tttgaaggca ggggtgtcct gtgcagtagt gaccctgggt ggcactggag     1800

agcctggcag ggcctgtgca gcacttgtaa accactggtc ccctcccttg ctgcctgtcc     1860

caacctcctg ctgggtttcc tcgagggtcc cggggctcct gcatgatccc ccacggtgtt     1920

ctccctcttg cagccgtgga gcaactgcgt gtgcacgtca gacggcacaa gggggtgagg     1980

aagtttgagt gcaccgagtg tggctacaag tttacccgac aggtaggcca gggcctgggc     2040

cccttcccct accctaggat cccccaaagt tctgagctca ccctccccgc caggcccacc     2100

tgcggaggca catggagatc cacgaccggg tagagaacta caacccgcgg cagcgcaagc     2160

tccgcaacct gatcatcgag gacgagaaga tggtggtggt ggcgctgcag ccgcctgcag     2220

agctggaggt gggctcggcg gaggtcattg tggagtccct ggcccagggc ggcctggcct     2280

cccagctccc cggccagaga ctgtgtgcag aggagagctt caccggccca ggtgtcctgg     2340

agccctccct catcatcaca gctgctgtcc ccgaggactg tgacacatag cccattctgg     2400

ccaccagagc ccacttggcc ccacccctca ataaaccgtg tggctttgg                 2449


<210> 4459
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 4459
actgcgcatg cgtgtcagtg gcgctagcgg cggacccggc tgggcagttc cttccccaga       60

aggagagatt cctctgccat ggagtcctac gatgtgatcg ccaaccagcc tgtcgtgatc      120

gacaacggat ccggtgtgat taaagctggt tttgctggtg atcagatccc caaatactgc      180

tttccaaact agagcaccga gggctgcttt caatccgcta tcccatggag catggcatcg      240

tcaaggattg gaacgacatg gaacgcattt ggcaatatgt ctattctaag gaccagctgc      300

agactttctc agaggagcat cctgtgctcc tgactgaggc gcctttaaac ccacgaaaaa      360

accgggaacg agctgccgaa gttttcttcg agaccttcaa tgtgcccgct cttttcatct      420

ccatgcaagc tgtactcagc ctttacgcta caggcaggac cacaggggtg gtgctggatt      480

ctggggatgg agtcacccat gctgtgccca tctatgaggg ctttgccatg ccccactcca      540

tcatgcgcat cgacatcgcg ggccgggacg tctctcgctt cctgcgcctc tacctgcgta      600

aggagggcta cgacttccac tcatcctctg agtttgagat tgtcaaggcc ataaaagaaa      660

gagcctgtta cctatccata aacccccaaa aggatgagac gctagagaca gagaaagctc      720

agtactacct gcctgatggc agcaccattg agattggtcc ttcccgattc cgggcccctg      780

agttgctctt caggccagat ttgattggag aggagagtga aggcatccac gaggtcctgg      840

tgttcgccat tcagaagtca gacatggacc tgcggcgcac gcttttctct aacattgtcc      900

tctcaggagg ctctaccctg ttcaaaggtt ttggtgacag gctcctgagt gaagtgaaga      960

aactagctcc aaaagatgtg aagatcagga tatctgcacc tcaggagaga ctgtattcca     1020

cgtggattgg gggctccatc cttgcctccc tggacacctt taagaagatg tgggtctcca     1080

aaaaggaata tgaggaagac ggtgcccgat ccatccacag aaaaaccttc taatgtcggg     1140

acatcatctt cacctctctc tgaagttaac tccactttaa aactcgcttt cttgagtcgg     1200

agtgtttgcg aggaactgcc tgtgtgtgag tgcgtgtgtg gatatgagtg tgtgtgcaca     1260

tgcgagtgcc gtgtggccct gggaccctgg gcccagaaag gacgatgaac tacctgcagt     1320

ggtgatggcc tgaggcctgg ggttgaccac taactggctc ctgacaggga agagcgctgg     1380

cagaggctgt gctccctcct caggtggcct ctggctggct gt                        1422


<210> 4460
<211> 1653
<212> DNA
<213> Homo sapiens

<400> 4460
aagttgccgg tggaattggc ccaggatgac agctggagaa tggagtcagt tttatccaag       60

tatgaagatc agattactat tttcactgac tacctagaag aatatccaga tacagatgag      120

ctggtatgga tcttagggaa gcagcatctc cttaaaacag attgggaaag aaagaccttt      180

taacctgaaa ctgctaacag cccagcaccc agataaagcc agagcttgga aagaggcagc      240

tctgagattt gtgtctttct gaggagacat cctcttcaga ggccctcact tagcgtggag      300

gaaggaacag gaagaggctg atgaaaaggc aggagaggaa gttaggcatt gtggagctcc      360

tcctgagcct ggcttcatta ttttgattgg agaattctga acagtggaaa gcctggagct      420

agcaattagg agaccttttg tattcagact cttctaactc agaaaaatct aagctgttgt      480

ctgatataag tgctcgtcta tggtttacat acagaaggaa attttcacca attggtggaa      540

cgggcccttc atcagatgct ggttggggat gtatgctacg ctgtggacag atgatgctgg      600

ctcaagccct tatctgtaga cacttgggaa gggactggag ctgggagaaa caaaaagaac      660

aacccaaaga ataccaacgc atcctacagt gcttcttaga tagaaaagat tgttgctact      720

ctatccatca aatggcacaa atgggtgtag gagaagggaa atcaattgga gaatggtttg      780

gaccaaatac agttgcacag gtgttaaaaa aacttgcttt atttgacgaa tggaattcct      840

tggctgttta tgtttcaatg gataacacag tggtcattga agatatcaaa aaaatgtgcc      900

gtgtccttcc cttgagtgct gacacagctg gtgacaggcc tcccgattct ttaactgctt      960

caaaccagag tgacgagctc atcttcttgg accctcatac aacccagacc tttgttgaca     1020

ctgaagagaa tggaacggtt aatgaccaga ctttccattg cctgcagtcc ccacagcgaa     1080

tgaacatcct aaacctggat ccttcagttg cattgggatt tttctgcaaa gaagaaaaag     1140

actttgataa ctggtgtagc cttgttcaga aggaaattct aaaggagaat ttaaggatgt     1200

ttgaattagt tcagaaacat ccatcacact ggcctccctt tgtacctcca gccaagccag     1260

aagtgacaac cactggggca gaattcattg actctactga gcaactggag gagtttgatc     1320

tggaggaaga ttttgagatt ctgagtgtgt agaatcctgg gaactcaact tgaaggtctg     1380

tcttccatct ggcaccataa aaacatgaac ttattgcata aaacttttct agtcagcaag     1440

tgcctgatat gccaatagca tacaaactca atagcaatca tgactgagcc aatcactgtt     1500

tctcagaaaa acaaaacaaa acaaaacaaa tgacagtaac ccttccccgg aaagaaatag     1560

aacaatcatg gagcctagga gcagagagat gaggaggagt tcattgcttc ccagcttgtg     1620

ttatatggct acagcaagtc ttcagctgct gca                                  1653


<210> 4461
<211> 1632
<212> DNA
<213> Homo sapiens

<400> 4461
acagaatgct gggctgagag caggactgag atcctagagg cagaatccca gtctacccgt       60

actctctggg aggaagtgat gagaacttgc agcagggtgg tggtagtgaa agagaagaat      120

gaaagacaag gaagcatcag tggaacttga tgtgtggctg gataccagaa atgcagagga      180

agttagtcaa aggttcccgt cctgatgact ggagatcatg gtatcactga ctgagctcta      240

ggggttgtga aatagagctc attaggcaga ggatgagagc acagtcagac gaactcgaaa      300

aaatagaaaa gcatggccga tcttccaaag acaaggaaaa tgccaagtct ctggacaaac      360

ctgaacagtt cctttatgaa ctgtcactaa tccccaactt ttcagagcga gtcttttgca      420

tcctgttcca gtccacattt tcagaaagca tttgctcaat tcgtcgcaaa ctggaattac      480

tacagaaatt gtgtgagaca ttaaaaaatg gcccaggggt tatgcaggtt ctaggtttgg      540

ttcttgcctt tggcaactac atgaatggag gaaataagac tcgaggacag gcagatggct      600

ttggattaga cattcttcca aaactgaaag atgtcaagag cagtgacaat agcagaagcc      660

ttttgtcata tattgtttcg tattatctcc gaaattttga tgaggatgct ggaaaagaac      720

agtgcctctt tccactgcca gaaccccagg acctttttca ggcctcacag atgaagtttg      780

aagattttca aaaagatctc agaaaactga agaaagactt gaaagcctgt gaagttgaag      840

cagggaaagt ataccaggtc tcctcaaaag agcatatgca gcctttcaag gaaaacatgg      900

aacaatttat tattcaagcc aaaattgacc aagaggcaga ggaaaattca ctgacagaga      960

ctcataaatg ctttttggag accacggcat atttcttcat gaaaccaaaa cttggagaga     1020

aggaggtgtc cccaaatgct ttcttcagta tctggcatga attcagctct gactttaaag     1080

acttctggaa gaaagagaac aaacttcttc tacaagagag agtaaaagaa gccgaagagg     1140

tgtgtagaca gaagaaagga aaatcacttt ataaaataaa accaagacat gactctggaa     1200

ttaaagcaaa gataagcatg aaaacttgaa caatgaaaag cagaatgaaa atgagtcatt     1260

gcaacgactt tcacaaaatt cagctgacct gagagtggga gggaaactac cgtcattctg     1320

ctcatgtttc ttcttgacct cttgcataat ctttttgttt tctagacagt tcactaattg     1380

ttgaatttta ctgtatattc atataaaaat gcaaacgtac tagaccagtg gagaatttga     1440

caccttttct ttttgtaaaa gtttatggta ttataccgat agaccaaaac agcatgtgta     1500

agaggcagta tctgcactaa ttctcaacat gctaaacatt aactacaatt cactgttgtg     1560

agaatattcc tcgtcacagc aaaaacactt tcctttctac tgacaaccag tcctccacat     1620

cacagcattt ag                                                         1632


<210> 4462
<211> 570
<212> DNA
<213> Homo sapiens

<400> 4462
ctgcttccgg gtcacgcctt gacagcggct ttcaaccccc acctcagccc agcaattcgt       60

accggaccta ccgggattgc tgcgatctgt ttagagcccg tgcagaaagt gacaccgcac      120

gtccttgcgt ttcgtgccct tgccccccgc cccctagcct cagcgagaca gctgccgcgg      180

gccctcccgc agcaggcagt ttggagcatg tgaacacctt gagccttgat gagttccagt      240

atgtggtata ttatgcagag cattcagagc aaatactctc tctccgagcg cttaatccga      300

acaattgctg ccatccgttc cttcccacat gataatgtag aggacctcat cagaggggga      360

gcagatgtga actgcactca tggcacactg aagcccttgc actgtgcctg tatggtgtca      420

gatgctgact gtgtggagtt acttctggaa aaaggagccg aggtgaatgc cctggatggg      480

tataaccgaa cagccctcca ctatgcagca gagaaagatg aggcttgtgt ggaggtccta      540

ttggagtatg gtgcaaaccc caatgctttg                                       570


<210> 4463
<211> 2224
<212> DNA
<213> Homo sapiens

<400> 4463
attctccggg ctgcggaggg taaagagcgg gctcgggccg aggctggagg gctgggtggg       60

gccagagcgg cgcttcgggg gcccgcggag gacgagggag ggagagaatc tgaggagctg      120

ggttgccatt aggggactcc tgaggtccta tctccaggct gcggtgactg cactttccct      180

ggagtggaag ctgctggaag gcggaccggc cgccatgtcc acgttcaggc aggaggacgt      240

ggaggaccat tatgagatgg gggaggagct gggcagcggc cagtttgcga tcgtgcggaa      300

gtgccggcag aagggcacgg gcaaggagta cgcagccaag ttcatcaaga agcgccgcct      360

gtcatccagc cggcgtgggg tgagccggga ggagatcgag cgggaggtga acatcctgcg      420

ggagatccgg caccccaaca tcatcaccct gcacgacatc ttcgagaaca agacggacgt      480

ggtcctcatc ctggagctgg tctctggcgg ggagctcttt gacttcctgg cggagaagga      540

gtcgctgacg gaggacgagg ccacccagtt cctcaagcag atcctggacg gcgttcacta      600

cctgcactct aagcgcatcg cacactttga cctgaagccg gaaaacatca tgctgctgga      660

caagaacgtg cccaacccac gaatcaagct catcgacttc ggcatcgcgc acaagatcga      720

ggcggggaac gagttcaaga acatcttcgg caccccggag tttgtggccc cagagattgt      780

gaactatgag ccgctgggcc tggaggcgga catgtggagc atcggtgtca tcacctatat      840

cctcctgagc ggtgcatccc cgttcctggg cgagaccaag caggagacgc tcaccaacat      900

ctcagccgtg aactacgact tcgacgagga gtacttcagc aacaccagcg agctggccaa      960

ggacttcatt cgccggctgc tcgtcaaaga tcccaagcgg agaatgacca ttgcccagag     1020

cctggaacat tcctggatta aggcgatccg gcggcggaac gtgcgtggtg aggacagcgg     1080

ccgcaagccc gagcggcggc gcctgaagac cacgcgtctg aaggagtaca ccatcaagtc     1140

gcactccagc ttgccgccca acaacagcta cgccgacttc gagcgcttct ccaaggtgct     1200

ggaggaggcg gcggccgccg aggagggcct gcgcgagctg cagcgcagcc ggcggctctg     1260

ccacgaggac gtggaggcgc tggccgccat ctacgaggag aaggaggcct ggtaccgcga     1320

ggagagcgac agcctgggcc aggacctgcg gaggctacgg caggagctgc tcaagaccga     1380

ggcgctcaag cggcaggcgc aggaggaggc caagggcgcg ctgctgggga ccagcggcct     1440

caagcgccgc ttcagccgcc tggagaaccg ctacgaggcg ctggccaagc aagtagcctc     1500

cgagatgcgc ttcgtgcagg acctcgtgcg cgccctggag caggagaagc tgcagggcgt     1560

ggagtgcggg ctgcgctagg cgcagtgggg tgggccaggc cccaggacag ccggagctcg     1620

gcctgcggtg ggggcgcttc ctgtggacgc tgcgcctccc atcgcccggg tgcctgtcct     1680

tgcccagcgc caccaggctg gaggcggagt gggaggagct ggagccaggc ccgtaagttc     1740

gcaggcaggg gtgggtgtgg gacggggctg cttctctaca cagcctccac gctggccttc     1800

accttcaccc ctgcatcgtc ggtgaccctg ggaccctcca ggcagcgtgg cctgtggcac     1860

cgtgagggtt gggacccacc gaggcgcaga ggcggcccga atgcagccct ggttcaggcc     1920

cggaggaggg tttgcgggta gttgcacgga caattcggcg gggtgctgcc tgttgctgcc     1980

attagcccag gaggaggtcg tgggacgggg agggtgggat ggacggcgga caggcagtcc     2040

ccacgctgct gggtggcgcc gggcttggtg gggtcttcca ctgtgtgccc ttctcgccga     2100

ggccggtccc ccgggtgtgg ggtgccctgc tgcggactcc tccgcgagcc ccatcgtcgc     2160

gcctgtggac gcctaggcaa gagcggccct ctgcagccaa gagaaataaa atactggctt     2220

ccag                                                                  2224


<210> 4464
<211> 3068
<212> DNA
<213> Homo sapiens

<400> 4464
ggggattggg gtcgggtcct ccccagtgag aggcgacagg agctcactgc ctctcgggcc       60

ctcacaatca cacctgtcac aggtatacac gctgccactc acaaacacac gcttgcactc      120

ccagcctcac tgacacgctg ccatacagcc gctcacagcc agccagacac tgctgcacct      180

gagagcaggt ggccgcgggt cttctccctt cactctccac atttggggat caggtccggc      240

acctgctgcg ccagacaggc cttgctgggc acgcgcctct gagagtccaa ggaggtggct      300

tccagagctg cagcacttca ggccggctcc ggtggagcga tcagagaaac aaggagacca      360

gtgctggtcc agtggctgtg atgggaaaag attattacaa gattcttggg atcccatcgg      420

gggccaacga ggatgagatc aagaaagcct accggaagat ggccttgaag taccacccag      480

acaagaataa agaacccaac gctgaggaga agtttaagga gattgcagag gcctatgatg      540

tgctaagtga ccccaagaaa cggggcctgt atgaccagta tggggaggaa ggcctgaaga      600

ccggcggtgg cacatcaggt ggctccagtg gctcctttca ctacaccttt catggggacc      660

cccatgccac ctttgcctcc ttctttggtg gctccaaccc cttcgatatc ttctttgcca      720

gcagccgctc cactcggccc ttcagtggct ttgacccaga tgacatggat gtggatgaag      780

atgaggaccc atttggcgct ttcggccgtt ttggcttcaa tgggctgagt aggggtccaa      840

ggcgagcccc agaaccactg taccctcggc gcaaggtgca ggacccccca gtggtgcacg      900

agctgcgggt gtccctggag gagatctacc atggctccac caagcgcatg aagatcacaa      960

ggcgtcgcct caaccctgat gggcgaactg tgcgcaccga ggacaagatc ctgcacatag     1020

tcatcaagcg tggctggaag gaaggcacca agatcacctt ccccaaagaa ggcgacgcca     1080

cacctgacaa catccctgct gacatcgtct ttgtgctcaa agacaagccc catgcacact     1140

tccgccgaga tggcaccaac gtgctctaca gtgccctgat cagcctcaag gaggcgctgt     1200

gtggctgcac tgtgaacatt cccactatcg acggccgagt gatccctttg ccctgcaatg     1260

atgtcatcaa gccaggcacc gtgaagagac tccgtgggga gggccttccc ttccccaaag     1320

tgccaactca gcgaggagac ctcattgttg agttcaaagt tcgcttccca gacagattaa     1380

caccacagac aagacagatc cttaagcagc acctaccctg ttcctaggct ctgccccagc     1440

cagtccagag cctaccacag caataccccc aacactcact ccactcaatg tgcacccagc     1500

ttgatgtcca ctggacactg gcaacttttt ctaaaatgca aaaaaaagcc actggttttc     1560

aggaaaatgt tcctgtccct gacccctttt agagctgggc tgcctggggg gagtgggagg     1620

gaggtgggga gagctagccc aggccagggg tcaatgttca tgtcactagc tttcaatcca     1680

gtttccactg cagtggctgg agagtgacct gagtgctact tgaagatatg tagagattcc     1740

ttatccatgc ctgtacatag catgtcctcc tcccctcagc tttgctaata ccagtcccct     1800

cccttccctt tggcttcctg ctgttggggg tggaaaagac tagaaaggac attgctttct     1860

cagccccacc cccaggtcca cagtgtccaa ggtaatggca cacatattca tgcacaagaa     1920

gcactcacct agagctgtct gtgcctctct gggagaaagg agagaggata agaagggaaa     1980

gttcacaacc tgtgaacagg gacttgagca cgagacactt ttcatctgga gcaggggggt     2040

gagctcctca gcagcctccg taacagctgc cctgcctaca cctgcagagc tggaggttct     2100

gtcctccctg ctgctctcag gagtgttcaa gggtggaggg cagggaatgg ggcctgaggt     2160

attaaggcta agaggtgggg gacagggccc atctaccagc cttcatcagg aagggaaagg     2220

gctttggggt caggtggcag ctattcccca ccaagagatt cagggtcaca ggtttttccc     2280

cacacctctg aactcagggc ctagccaccc ccaaacttcc aaatcccact tttgtgatat     2340

gtgaagctac tcatttctta cccttggagg ctgtgtgggg aatttccagc ccttttatgc     2400

ctgtgtgatc ccaccccacc cccatagttg tataaaggtc atagtgaaga agctggggga     2460

agactgcttc agccagatcc tggggtgggg tctttaggtt ttctcacttt gacaaccccc     2520

gaatgttttt atagtagttt ttttgtattt ttttgtaatg acagtattat gtaaaaaata     2580

aagtatttta aaaatatggc atctgagcag gagcaacaaa cctgggatgg gggtggctga     2640

ggagggccac tgtcatcctc cctcccgggc tctggtcacc tttgagaagc ccaagcaggc     2700

cctcagtata agctgaagct gacctctgcc ttcctcgaag cctcctggga tttctaaaac     2760

ttatacttca aacacagcac agacagaaag taccactcag ctattagaag aaacatctat     2820

ttgggaagga aaaatatccc tgctcatgag agacagagac cattgtcttc agatgtgcta     2880

gcatgaaaac agattttctc ttcttgtcta aattttctct gagtcagaca aattttcctt     2940

ctaggagaaa atttttttct aggagggggt ggagaacttt tttttttttt tttttttttt     3000

gacacggagt cttgctctgt cgcccaggct ggagtgcagt gatgcgatct tggttcactg     3060

cagcctct                                                              3068


<210> 4465
<211> 2881
<212> DNA
<213> Homo sapiens

<400> 4465
gcggcggtgc ctgggcggca gcagcagcag tagcggcagc cctgaggacg atatggtgta       60

agatacttct tcaagattgg acagctgggg accttcttct gattaacctt aaaccaactt      120

gtagccatag agacacctca caaggttccc atttttgttg ttgttgttgt tgattttctg      180

ctcacacctt tcctgacctt gcaaccatgt atggaagtgc ccgctctgtt gggaaggtgg      240

agccgagcag ccagagccct gggcgttcac ccaggcttcc acgttcccct cgcttgggtc      300

accgtcgaac caacagtacg ggagggagtt cgggaagcag tgttggaggt ggcagtggga      360

aaaccctttc aatggaaaat atacaatctt taaatgctgc ctatgccacc tctggcccta      420

tgtatctaag tgaccatgaa aatgtgggtt cagaaacacc taaaagcacc atgacacttg      480

gccgttctgg gggacgtctg ccttacggtg ttcggatgac tgctatgggt agtagcccca      540

atatagctag cagtggggtt gctagtgaca ccatagcatt tggagagcat cacctccctc      600

ctgtgagtat ggcatccact gtacctcact cccttcgtca ggcgagagat aacacaatca      660

tggatctgca gacacagctg aaggaagtat taagagaaaa tgatctcttg cggaaggatg      720

tggaagtaaa ggagagcaaa ttgagttctt caatgaatag catcaagacc ttctggagcc      780

cagagctgaa gaaggaacga gccctgagaa aagatgaagc ttccaaaatc accatttgga      840

aggaacagta cagagttgta caggaggaaa accaggtgga tgctctccga ttgcgtttgg      900

aagagaagga aaccatgttg aataaaaaga caaaacaaat tcaggatatg gctgaagaga      960

aggggacaca agctggagag atacatgacc tcaaggacat gttggatgtg aaggagcgga     1020

aggttaatgt tcttcagaag aagattgaaa atcttcaaga gcagcttaga gacaaggaaa     1080

agcagatgag cagcttgaaa gaacgggtca aatccttgca ggctgacacc accaacactg     1140

acactgcctt gacaactttg gaggaggccc ttgcagagaa agagcggaca attgaacgct     1200

taaaggagca gagggacaga gatgagcgag agaagcaaga ggaaattgat aactacaaaa     1260

aagatcttaa agacttgaag gaaaaagtca gcctgttgca aggcgacctt tcagagaaag     1320

aggcttcact tttggatctg aaagagcatg cttcttctct ggcatcctca ggactgaaaa     1380

aggactcacg gcttaagaca ctagagattg ctttggagca gaagaaggag gagtgtctga     1440

aaatggaatc acaattgaaa aaggcacatg aggcagcatt ggaagccaga gccagtccag     1500

agatgagtga ccgaatacag cacttggaga gagagatcac caggtacaaa gatgaatcta     1560

gcaaggccca ggcagaagtt gatcgactct tagaaatctt gaaggaggtg gaaaatgaga     1620

agaatgacaa agataagaag atagctgagt tggaaagtct cacctcaagg caagtgaaag     1680

accagaataa gaaggtagca aatctgaagc acaaggaaca ggtggaaaaa aagaagagtg     1740

cacaaatgtt agaggaggcg cgacgacggg aggacaatct caacgacagc tctcagcagc     1800

tacaggacag tctccgtaag aaggatgaca ggattgaaga gctggaagaa gcactaagag     1860

aaagtgtaca gataactgca gagcgggaaa tggtgctagc acaagaggaa tcagccagga     1920

ccaatgctga aaaacaggtg gaggagttac tgatggccat ggagaaggta aagcaggaac     1980

tagaatccat gaaagcaaag ctgtcctcca cccagcagtc tctggcagaa aaggaaactc     2040

acttgactaa tcttcgggca gagagaagga aacacttaga ggaagttctg gagatgaagc     2100

aagaagctct tctggctgcc attagtgaaa aagacgccaa tatagctctc ttggagcttt     2160

cgtcctctaa gaagaagacc caagaggaag tggctgccct gaagcgggag aaggatcgtc     2220

tggtacagca gcttaagcag cagacgcaaa atcgaatgaa gctaatggcc gacaactacg     2280

aggatgacca cttcaaatcc tcccattcca atcaaacaaa tcacaagccc tccccagacc     2340

aggatgagga ggagggtata tgggcatagc caatcagagg cttagttcag ccattttgtt     2400

cagaacgatc atccagcccc tcttagaact tgaccaaaat agaagtaaat taaagttgta     2460

cattggacac ctgacaaccc tctgccatga ccgagacccc ctgatcctcc gtggactcac     2520

tccaccagct tcctataact tggacgatga ccaggcggct tgggagaatg agctgcagaa     2580

gatgacccgg gggcagcttc aggatgagtt agagaaaggt gaacgggaca atgcagaact     2640

gcaggagttt gccaacgcca ttcttcagca gatagcagac cattgtcccg acatcctaga     2700

gcaagtggtc aacgccctgg aagagtcctc ttgaccctgc tttatgggga agcctgaggt     2760

agtcaaccca ggagccaaga aaagagaact acgaggaaca ggtgcccgga accttcttgg     2820

caccaaacac tacaaacttc atcccaactt gctcacttga agaagtgtga ttccagcacc     2880

g                                                                     2881


<210> 4466
<211> 768
<212> DNA
<213> Homo sapiens

<400> 4466
atggccgcgt ccaccatgtc cgtctgctcc agcgcttgct ccgactcctg gcaggtggat       60

gcctgcccag agagctgctg tgagccccac tgctgcgccc tcagctgctg cgccccggcc      120

ccctgcctga ccctggtctg caccccagtg agccgtgtgt ccagcccctg ctgccaggca      180

gcctgtgagc ccagcccctg ccaatcaggc tgcaccagct cctgcacgcc ctcgtgctgc      240

cagcagtcta gctgccagcc ggcttgctgc acctcctccc cctgccagca ggcctgctgc      300

gtgcccgtct gctgcaagcc tgtgtgctgc ctgcccacct gctctaagga ttcctcttca      360

tgctgccagc agtctagctg ccagccaact tgctgtgcct cttcctccag ccagcagtcc      420

tgctgtgtgc ctgtttgctg caagcctgtg tgctatgtgc ccacctgctc tgaggattcc      480

tcttcatgct gccagcagtc tagctgccat ccagcttgct gcacctcctc cccctgccag      540

caggcctgct gcgtgcccgt ccgttgcaag cctgtctgct gcaagcccat ctgctgtgtg      600

cccgtctgct ctggggcttc cacttcatgc tgccagcagt ctagctgcca gccggcttgc      660

tgcaccacct cctgctgcag accctcctcc tccgtgtccc tcctctgccg ccctgtatgc      720

cggcccgcct gctgtagcct ctgctcaggc caggagtcca gctgctga                   768


<210> 4467
<211> 3257
<212> DNA
<213> Homo sapiens

<400> 4467
gtctgcgcaa gcgctaacca agaaacgacg gtttcgggta gattgttggt taagaagaaa       60

gctgggaaag tgaaggagag ggggaagaaa ggaagtgaaa agactttggc tgttggaatc      120

tcagatctgg aataggctgt ataggctatt tataatctct aattgccgag gaacctgaag      180

ttcagagtta accagtgact gactcaggac atgcaaaatg gcaagacccg aggtagaaga      240

gctcaccttt cctgactctc agtttcctgt tccctgaaaa ttcccagcaa gggggaggta      300

catggaaggc cacaggaaga aacaagatct tgagctgagc aagaacatcc cagcatcttc      360

attgacttta aaagtatatt ctggagtctt ccgtggttca ctattccagt actacagaga      420

ttccttatat tacatggcag gaggggggta aactgaggga tagtgaagac aacaataaat      480

taatcaagag ctttcctcat atctcagaac ctatcctctg taagaatgtc agaaaaggtt      540

gactggttac aaagccaaaa tggagtatgc aaagttgatg tctattctcc tggagacaac      600

caagcccagg actggaaaat ggacacctcc acggatcctg tcagagtgct cagctggctc      660

cgcagagacc tggagaagag tacagcagag ttccaagatg ttcggttcaa acccggagaa      720

tcatttggtg gggaaacgtc caactcagga gacccacaca aaggtttctc tgtagactat      780

tacaacacca ccaccaaggg cactccagaa agattgcatt ttgagatgac tcacaaagag      840

attccttgcc agggccccag ggcccaactt ggcaacggga gttcagtaga tgaagtttcc      900

ttctatgcta accgcctcac gaatctagtc atagccatgg cccgcaaaga gatcaatgag      960

aagatcgatg gctctgaaaa caaatgtgtc tatcagtcat tgtacatggg gaatgaaccc     1020

acacccacca aaagcctcag taagatagca tcagagcttg tgaatgagac cgtctctgca     1080

tgttccagga atgctgcccc agacaaggct cctggctctg gagacagagt ctcgggatca     1140

tcacaaagtc ccccaaattt gaaatacaag tccactttga agatcaagga gagcaccaaa     1200

gaaagacagg gtccagatga caagcctcct tctaagaagt ctttcttcta taaggaagtg     1260

tttgaatctc gtaatggaga ttatgccaga gagggtggaa ggttctttcc tcgggagaga     1320

aagaggtttc gagggcagga aaggcctgat gactttacgg cttctgttag tgaagggatc     1380

atgacctatg ctaacagtgt ggtatctgat atgatggtct ccatcatgaa gacactgaag     1440

atccaagtga aagacacaac cattgccacc atcctactga agaaggttct gctcaagcat     1500

gcaaaagagg tggtctcgga tctcatcgac tccttcttga ggaatctcca cagcgtcaca     1560

gggaccctca tgactgacac acagtttgtc tcggctgtga aaagaactgt cttctctcat     1620

ggaagccaaa aggccacaga tatcatggat gccatgctaa ggaagctgta caatgtaatg     1680

tttgccaaga aagtccctga gcatgtcagg aaagcccaag acaaggctga gagttattcc     1740

ctcatctcca tgaaaggaat gggtgatcct aaaaaccgaa atgtgaactt tgccatgaaa     1800

tctgaaacta aattgagaga aaaaatgtat tctgaaccca aatcagagga ggagacttgt     1860

gcgaaaactc tgggtgagca cattatcaaa gaggggctta ccttgtggca taaaactcag     1920

cagaaagaat gtaaatctct aggtttccag catgcagcat ttgaagctcc caacacacag     1980

cgtaagcctg catcagacat ttcctttgag taccctgaag atattggcaa cctcagcctt     2040

cctccatatc ctccagagaa acctgagaat tttatgtatg attcagactc ctgggccgag     2100

gacctgatcg tgtctgccct gcttctgatt caatatcacc tggcccaggg aggaagaagg     2160

gatgcacgga gcttcgttga agctgctggc accaccaact ttcctgccaa tgaacctcct     2220

gtagctcccg atgaatcttg ccttaagtct gctcccattg taggtgacca agaacaagca     2280

gaaaagaagg acctaaggag tgttttcttt aatttcatcc ggaacttact tagtgagacc     2340

attttcaagc gtgaccagag ccctgaaccc aaggtgccgg aacagccagt taaggaagat     2400

aggaagttgt gtgaaagacc gttggcgtct tctcccccca ggctatatga ggatgatgag     2460

acccctggtg ccctttctgg gctgaccaag atggctgtca gccagataga tggccacatg     2520

agtgggcaga tggtagaaca tctgatgaac tcagtgatga agctgtgtgt catcattgct     2580

aagtcctgtg atgcttcgtt ggcagagctg ggagatgaca agtctggaga tgccagtagg     2640

ctaacttcgg ccttcccaga tagtttatat gagtgcttac cagccaaggg cacagggtca     2700

gcagaagctg tcctgcagaa tgcctatcaa gctatccata atgaaatgag aggcacatca     2760

ggacagcccc ctgaagggtg tgcagcaccc acggtgattg tcagcaatca caacctaacg     2820

gacacagttc agaacaagca actccaagcc gtccttcaat gggtagctgc ctctgagctc     2880

aatgtcccta ttttgtattt tgctggtgat gatgaaggga tccaggagaa gctacttcag     2940

ctctcagctg ctgctgtgga caaaggatgc agtgtgggcg aggttctgca gtcggtgctg     3000

cgctatgaga aggagcgcca gctgaatgag gcggtgggga atgtcacacc gctgcagctg     3060

ctggactggc tgatggtgaa cctgtaatcg gcaaccccac tgctttcccc tcttctggca     3120

gtggggccgg cccttatccc cgcccttctt tctcacttcc acatctcccc ctctatatcc     3180

tcacagagcc ctaacattat cttcacacca ctctcatcaa agacatgtca tcttgtgcta     3240

gccactggat tttgcag                                                    3257


<210> 4468
<211> 1906
<212> DNA
<213> Homo sapiens

<400> 4468
ctacgagcgg catcctgcct gcgttagcgg cggtggagga ggaggcagag aggagtggag       60

ggcggagtag acggaggagg ctgctgcaga gaagaaagtg tcagagccgg ttcggcttta      120

gagtgtggtg aagggtactt ttcatggtgc atggaaggaa agccaatgcg caggtaatgg      180

agagtgaaga gttcatgttg cttccagcca atcaactcat tgatataata tccagtgatg      240

agctaaacgt tcgcagtgaa gaacaagtgt tcaatgcagt gatggcctgg gtcaaataca      300

gtattcagga aagacgtcct caattacccc aggtgctgca gcatgttcgt ttgcctttgc      360

ttagtcccaa gttcctggtc ggcacagtag gctctgatcc cctcatcaaa agtgatgaag      420

aatgcagaga cttggtagat gaggctaaaa actacctcct attgccgcaa gaacgaccac      480

taatgcaagg accaaggacg agaccacgga aacctatccg atgtggggaa gtactctttg      540

cagttggtgg ttggtgcagt ggagatgcca tttccagtgt tgaacgatat gatccacaga      600

ccaatgaatg gagaatggtg gcttcaatga gcaaaaggag atgcggagtt ggggtcagtg      660

ttcttgatga tctgttatat gcagtaggag gccatgatgg atcctcttat ctcaatagtg      720

ttgaaaggta tgaccccaaa acaaaccagt ggagcagtga tgtggcccct acaagcacct      780

gcaggacaag tgttggtgta gcagtacttg gaggctttct ttatgctgtg ggtggccagg      840

atggtgtgtc ttgcctcaac attgttgaga ggtatgatcc gaaggagaac aagtggactc      900

gggtagcttc tatgagtacc agaagactag gtgtggctgt ggctgtgtta ggagggttct      960

tatatgctgt aggtggctct gacgggacat ctcctctcaa cacagtggaa cgttacaatc     1020

ctcaggaaaa cagatggcac actatagccc ctatggggac ccggaggaaa cacctaggct     1080

gtgcagtata tcaggacatg atctatgctg taggaggtag agatgacact acagagctga     1140

gcagtgctga gagatacaac cccagaacca accagtggtc tccagtggtg gccatgacat     1200

cacgccgtag tggagttggc ctggcagtgg tcaatggaca gctcatggca gtaggaggtt     1260

ttgatggcac aacatacttg aagaccatag aagtttttga tcctgatgcc aatacatgga     1320

ggttatatgg cgggatgaat taccgtcggc tagggggtgg cgtaggagtt attaaaatga     1380

cacattgtga atcccatatt tggtgaacac agagaagaca gtcttgtata tattcctctg     1440

tattctgggg agctttgacc ttggagcttt gtacagcttg agaaaacatt agaacaaatt     1500

ttattatttg ccggtgcctc aacaaatgga aatacaatcc aatgaaagta cttcacctgc     1560

aagatgcaca ataattttca actctgtgca gaagaatatt tatttttggt tttaatttat     1620

catggttttt tgttgttttc gttttgaact tatccttcct cccacaaaaa aagaaaagaa     1680

gaaaaaattc caagcagcaa aacttacttt gtttgtaagg tattcattta ggtttgaaaa     1740

tactatttaa taagggcaga agggctatat atgatttggc tattatttct agacactcca     1800

tccacatgat tccactaaca aggattacca ggaataaagg taggtatgca aaatgtatta     1860

gctacccatt attctcgcac taaccaccag aagacttgaa aatctt                    1906


<210> 4469
<211> 956
<212> DNA
<213> Homo sapiens

<400> 4469
ggtcggcgga ggtgtctacc ccgccggtga tggcgttgaa cgccactggc ttcccggcct       60

tccgtccgct gcctccgtcc gattctgcgt ctgcttgctg aggaggcgga ttaggggggc      120

gcggagtctc ttcccttgag tgcataggtc ccggttggta gagggtttga gtccgcatcg      180

ccacagctga aggctgcgag ggactaagag cagaatatat ctttagaaat gagttgcaca      240

attgagaagg cacttgccga cgctaaagct cttgttgaaa gattaagaga tcatgacgat      300

gcagcagaat ctctgattga gcaaaccaca gctctcaaca agcgagtaga agccatgaaa      360

cagtatcagg aagaaattca agaacttaat gaagtcgcga gacatcggcc acggtccacg      420

ttagttatgg gaatccagca agaaaacaga caaatcagag agttgcaaca agaaaacaaa      480

gaattacgta catctctgga agaacatcag tcggccttgg aacttataat gagcaagtac      540

cgagaacaaa tgtttagatt gctaatggct agcaaaaaag atgatccggg tataataatg      600

aagttaaaag agcagcactc caagattgac atggtacatc gtaacaagtc cgaaggattc      660

ttccttgatg catctcgaca catccttgaa gcacctcaac atggactgga gagaaggcac      720

ttggaagcaa atcagaatgt acactaaata aacagtcaac ttttggggtg tggatggaag      780

gggggtccat tttaaaagtg cttttacatt gaatttccct cccagattag atcagcaaat      840

aaatgaaatt tattaaaaga atgttgtgtc tttaatagcc atgctgttca gtgtagaaac      900

tttaaatctc tcattaattt tctgtgtatt gtatcatgta cagcctgtta gatatt          956


<210> 4470
<211> 2671
<212> DNA
<213> Homo sapiens

<400> 4470
atgttattta tttttcctct ttccctcccg tggagaccct cctgttggaa agagagctgc       60

agcacgggac agagacaggc aggaagaagc agagaggact cggtgacgcc cccaccgagc      120

agcccctggc ccactcctcc agcaggggcc atgagcacca agcaggaggc caggagagat      180

gagggagaag ccaggacgag ggggcaggag gcacagcttc gagaccgagc ccacctgagc      240

ctgcacaagg actcggccga cctgctcccg ctggacagcc tcaagaggct cggcacctcc      300

aaggacttgc agccgcgcag tgtgatccaa agacgcctgg tggagggaaa cccgaattgg      360

cttcaggggg agcctccccg gatgcaggac ctgattcatg gccaggagag caggaggaag      420

accagcagga cagagattcc agctcttctg gtcaactgca agtgccagga ccagctgctt      480

agagtggccg ttgacacagg cacccaatac aatcggatct ctgctggatg tctcagccgc      540

ctggggttag agaaaagggt cctaaaagcc tcagctgggg acctggcccc tgggccccca      600

acccaggtgg agcagttgga gctacagctg gggcaggaga ctgtggtgtg ctcggcacag      660

gtggtggatg ctgagagtcc tgaattctgc ctgggcctgc agactctgct ttctctcaag      720

tgctgcatcg acctggagca cggagtgctg cggctgaaag ccccgttctc agagctaccc      780

ttcctgcctt tgtaccaaga gcctggccag tgactgctgt ctcagtcagt ccccagaggg      840

aaagaccttg ccttagaaga agaggcgtgt ggggaacggg ggctcttgaa gccaggtagc      900

tggggactat ggtgtctgcc cttccaatca cctccctgac ccctgctgtc ccattttccc      960

cagctggccg cattcctctc tgcttctcag cagctgtcct actccccagg acgagttttc     1020

actagagggc ccacgatgcc aggattctga ttcatcttcc tcccaagaaa agcaaagcca     1080

aatcaagacc acagatagga acctaagcac aatggggtgc ctgcttgggc tgggtcgaag     1140

gctctgctga ctgctgtcct tgtccatcac ccaataccac cccaaacaca actcaacttc     1200

ccacaccacc atgtctctca ccacaccttc tgggcctcat tatctcccac aactagaccg     1260

ccatgcctca ccaacctatg tccctggacc tcctggtgtc tgcctctcgg agtctgtgca     1320

catctgctca cagttgagtg ggggaagaaa cagccagaat tcaatacaac aaagagcggg     1380

agttagtata ggaatgtcca tctcataagg ctgagagcta ttttttcctg tggctgcaaa     1440

tgtctgaagc cagttagttt gattaccctg tgcaaaacct tggacatact tctgctatta     1500

acgctatagg tatttatccg tttccactgg ctttttgtac ccaccgagcc cctgagcctt     1560

gcgtgtgtgt gtgtggaaga gccttgtaga gaactgctcc tgtgaggcag acaggacagt     1620

gaggttgtca ccactcagac ttcacctatt cagcattctt tctgatttct agaactatcc     1680

acctcattag gccttcttcc tatccccatc tctggcctct tgagcttaag cttgtattgt     1740

cctggaatca gtggctttct aaccccctgc caggctttgc caaagcaaaa agacagaggc     1800

tttttttttt tttttaaagt ttggggtctg tcaggagaca gaggcttttt tgaattcact     1860

gtgaagagaa gaacccgaac cttaagacgc cagatccctg agagtctttc tggctggttt     1920

gagtctctca aatcatggat taggagtaaa gaaagaggcc aggcgcaatg gctcatgcct     1980

gtaatcccag cactttggga ggctgaggtg ggtggatcac ttgaggtcag gagtttgaga     2040

ccagcctggg taatatggca aaaccccatc tctactaaaa aatacaaaaa ttagccaggt     2100

atggtggtga acacctgtaa tcccagctac ttggaaggct gaggcatagg agttgcttga     2160

acctgggaga tgggggttgt agtgagccaa gttcgtgcca tcggactcca gcctgggtga     2220

aggagtgaga ccctgtctcc aaaaacaaac aaaaaaggag cagagaaaga cagtggtaca     2280

gctaacctga acaagggaac tgggaccgtt gggctgaaac agtcttgagc ctggggttga     2340

ctgggttaga gaagaaccgg gatgcaagga gctgcctgtg acacctggcc tgccctttct     2400

cagctgcctc ccctgccctt tctcagctgc ctcccctgcc ctcagaagga aaggagaggg     2460

ctcacttatc acttgtgcca tagcacctgg tctcaaaatc ctaaaagctt tcctcgccct     2520

cactgccttg ctccacaagg tccactttcc tgggtcttgt gctgtgcctt tccttgtctg     2580

cctcctgctg cttctgtaac tgcagacccc aggcccaatg gcaagccctc ggctcagctg     2640

cttctccatt ggaataaact cttgtttctc t                                    2671


<210> 4471
<211> 243
<212> DNA
<213> Homo sapiens

<400> 4471
acctcctgct gcagaccctc ctcctctgtg tccctcctct gccaccccgt gtgcagctgc       60

tccccagcct gccagccaac ctgctgcata cacagcccct gccaggcatc ctgctatgtg      120

cccgtgagct gccagcccat catatatgtg actccctctt gccaatcttc ggggtgctgc      180

cagcccccct gcaccactgc cctctgcaga cccatctcct gcagcacccc ttcctgctgc      240

tga                                                                    243


<210> 4472
<211> 2308
<212> DNA
<213> Homo sapiens

<400> 4472
gttttgggct gcggttggag ggccgcagtt gcagtcaggg tccgccagct cggggccagc       60

gcatggggct gctgagaccg ctccggacgt gcgaagcgtt cgcggtgcgg taggaagctg      120

aagtcttcag cagaaccctg acctaggtag ggagtctcaa tggccctggg tgaagaaaag      180

gcagaagcgg aagcatctga agacacaaag gcccagtcct atgggagagg gagctgcagg      240

gagcgggagc tggacatccc agggcccatg agtggggagc agcccccacg cctggaagct      300

gagggagggc tcatctcccc tgtatggggg gcagaaggga tacctgcccc tacttgctgg      360

attgggactg accctggcgg cccctctaga gcccaccagc cacaggccag tgatgccaac      420

agagagcccg tagctgagag gtctgagcct gcactcagtg gcctgcctcc tgccaccatg      480

gggtctggag accttctgct ctccggggaa agccaggtgg agaagaccaa gctttcttcc      540

tccgaggagt tccctcagac tctgagcctt cccagaacaa caactatttg ctcaggacat      600

gatgctgata ccgaagatga tccatcccta gcagatttgc cccaggcact ggacctcagc      660

cagcagcctc acagctcagg tctctcttgc ctgtcacagt ggaagtccgt gctgagccca      720

ggttccgcag ctcagccttc cagctgcagc atctctgctt cctccacagg cagcagtctc      780

cagggtcacc aggagagggc ggagcctcgt ggtggttctc tggccaaggt ctcctcctcc      840

ctggagccgg tcgtccccca ggaaccttcc tctgtggtgg ggctaggacc tcggccccag      900

tggtcaccac agcctgtgtt ctctgggggt gatgcttctg ggctaggcag gagacgcctc      960

tccttccagg ctgagtactg ggcctgtgtg ctgccagatt ccctgcctcc atcacccgac     1020

cgccactccc ctctctggaa cccaaataaa gagtatgaag atctgcttga ctatacttac     1080

ccactgaggc ccgggcctca gctcccaaag caccttgata gccgtgtgcc agctgaccct     1140

gtcctgcagg actccggggt agacctggat agcttctctg tctctccagc aagcaccctc     1200

aaatcaccta ctaatgtctc ccccaactgc ccaccagcag aggccactgc cctgccattt     1260

tctgggccca gagagccaag ccttaagcag tggccctcca gagtacccca gaaacagggt     1320

ggcatgggct tggcatcttg gagccaactt gcatctaccc ccagagcccc aggcagtagg     1380

gatgctcgtt gggagcgcag agagccagcc ctgaggggtg cgaaggaccg gctgactata     1440

ggcaagcacc ttgatatggg ctctccccag ctaaggacac gggacagagg gtggccctcg     1500

cccaggccag agagggagaa gaggaccagc cagagtgccc ggcgccctac ctgcacagag     1560

tctaggtgga aatcagaaga ggaagtggaa agtgatgacg agtatcttgc cctccccgct     1620

cggctgacac aggtttctag cctggtttcg tatctaggat ccatttctac cttggttacc     1680

ctgcccactg gggatatcaa agggcagagc cccttggaag tgtcagacag tgatgggcca     1740

gcttccttcc cttcaagctc cagccaaagc cagcttcccc ctggagctgc cctccaagga     1800

tctggggatc ctgagggcca gaatccctgt ttcctgcgct ccttcgtccg tgcccacgac     1860

tccgcagggg aaggcagtct ggggagcagc caggccctcg gggtctcctc tggactgctg     1920

aaaacacgcc cctccttgcc agctaggttg gaccggtggc cattctcaga cccagatgtt     1980

gaagggcagc ttcccaggaa aggaggagaa cagggaaaag aatcactggt gcaatgtgtg     2040

aagacatttt gctgtcagct ggaagagctg atctgctggc tgtataatgt tgcagatgtt     2100

actgaccacg ggactgcagc caggtccaat cttacaagtc tcaagtcttc tctgcagctt     2160

taccggtttt agaggatgtc cttgggagga tcgcaaagca gtctggtgag ctggagagcc     2220

acgcagatcg cctgtatgac tctatcttgg cctctctgga catgctggct ggctgcaccc     2280

ttatccctga caaaaagccc atggcggc                                        2308


<210> 4473
<211> 960
<212> DNA
<213> Homo sapiens

<400> 4473
gtttagttca gcgcagcgac tcggggacct ggagctgacg cctagacact tgtattagct       60

ttaatagaag agaaatggag gagccataga atattaagga tgaattcagg aaggcctgag      120

accatggaaa acttgcctgc tctctacact attttccaag gagagttatg gtgaagctga      180

aacagtgctc aagatgaagc agctaattga agacactgaa aagaataaag tttatgttgc      240

tatggtgaca gactatgggg cctttatcaa aatcccaggc tgtcggaagc aaggtctggt      300

ccatcgaact catatgtcat cctgtcgggt ggataagccc tctgagatag tagatgttgg      360

agataaagtg tgggtgaagc ttattggccg agagatgaaa aatgatagaa taaaagtatc      420

cctctccatg aaggttgtca atcaagggac tgggaaagac cttgatccca acaatgttat      480

cattgagcaa gaagagaggc ggaggcgatc cttccaggat tacactgggc agaagatcac      540

ccttgaggct gtcttgaaca ctacctgcaa gaagtgtggc tgtaaaggcc actttgcaaa      600

agattgtttc atgcaaccag gtgggactaa atactctctg atacctgatg aggaagagga      660

aaaggaagag gcaaagtcag cagagtttga gaagcctgac cctacaagga atccttctag      720

aaaaagaaag aaggagaaga agaaaaagaa acatagagat aggaagtcat ctgactctga      780

cagctcagac tctgagagtg atacaggcaa gagggcaagg cacacatcaa aagacagcaa      840

ggcagcaaag aagaagaaaa agaagaagaa gcacaagaag aagcacaagg agtgagagta      900

taaagagtgt agggggtggt tgagagtaag aaaccaggag ccttgtgcct tgagactcct      960


<210> 4474
<211> 853
<212> DNA
<213> Homo sapiens

<400> 4474
agccccttgt ggctgagggc agagctcttt gcgttggtcc acggtgtgct cctctgcccg       60

ggctccagga acactcggag gtgtctggct tccttctgga gtgtgacagc tcggtgcagg      120

gcgcgctgca gaagcacctc gcgctataca ggatccggcg gaaggtcacg gtggagccgc      180

acccggagct gcgagtgtgg gcggtgttgc ccagttcccc tgaggcctgc ggggctgcat      240

cgctgcagga gagggcaggg gctgccgcca tcctcatccg cgacccgcga acagcacgca      300

tggggtggcg gctcctcacc caggatgaag gcccagccct ggtgcccggg ggccggctcg      360

gggacttgtg ggattatcac cagcaccgat acctgcaagg cgttcctgag ggggtccgag      420

acttgcctcc tggggtggcc ctgcccctgg agtccaacct ggccttcatg aacggcgtga      480

gcttcaccaa aggctgctac attggccagg agctgacggc ccgcacccac cacatgggcg      540

tcatccgcaa gcgcctcttc cctgtccggt tcttggaccc ccttcccacc agtggcatca      600

cccctggtgc cacggtgctg actgcctcag gacagactgt gggcaagttc agggctggcc      660

agggcaacgt ggggctggcc ctgctgtggt cagagaagat caagggtcct ctgcacatca      720

gagcctctga gggtgcccag gtggccttag ccgcatctgt gccagactgg tggcctacag      780

tctccaagta gtccgaagcc ttggctggcg caggctgatg gggaggctgg ggcctggggc      840

ctttggcctc tgt                                                         853


<210> 4475
<211> 1110
<212> DNA
<213> Homo sapiens

<400> 4475
gcgcaactca ttggcgccaa gatggcgatg gagatgaggc ttccagtggc tcgcaagcct       60

cttagcgaga gactgggccg cgacactaag aaacatctag tggtgccggg ggatacaatc      120

actacggaca caggattcat gcggggccat ggaacgtata tgggagaaga gaagctcatt      180

gcatctgttg ctggctctgt ggagagagta aacaagttga tctgtgtgaa agctttgaaa      240

accagataca ttggtgaagt aggagacatc gtagtgggac gaatcacaga ggttcaacag      300

aagaggtgga aggtggagac caactccagg ctggattcgg tcttgctgct ctcgtccatg      360

aaccttcctg gaggagagct gaggagaaga tctgcagaag atgagcttgc aatgagaggt      420

ttcttacagg aaggggacct tatcagtggg gttttggtcc aggtttcccc ctccctggtg      480

aaacggcaga agacccactt tcatgatttg ccatgtggtg cctcagtgat tctcggtaac      540

aacggcttca tctggattta cccaacacct gagcacaaag aagaggaagc agggggcttc      600

attgcaaacc tggagcctgt ctctcttgct gatcgagagg tgatatcccg gcttcggaac      660

tgcatcatct cgctggtaac tcagaggatg atgctgtatg ataccagcat cctgtactgc      720

tatgaagcat cccttccaca tcagatcaaa gacatcttaa agccagaaat aatggaggag      780

attgtgatgg aaacacgcca gaggcttttg gaacaggagg gataaggagg tgctccagaa      840

gcacgggact gtggaccttg caggagtgaa gactgtgatg tgtggtcccc atatgtggct      900

cagcaaagac tcgagagatc atccctttgt ctgcattgac ggccctgtga cggcctccag      960

cccacaggcc tgctttctcc tgtcctaaca ccaagcctgg gtggcagatg aacagtgctt     1020

ccttgggttg ccagctgagt cccggtatta gggaatagtt tcagctcttt caaagtgcac     1080

agtgttacag tcgaatgggc tcccatcctg                                      1110


<210> 4476
<211> 3476
<212> DNA
<213> Homo sapiens

<400> 4476
aaaaatgtta ttcttagtag aaatggggaa atatcaaaga ggagtaagtt taagagttct       60

gtgatgccct taaaagtcga cggggaagtc cagcagctgg agatgagctc aaagcatgcc      120

tgtttttaag gaagtaaagg tacatctgtt agaagatgca ggcatagaga aggatgctgt      180

tactcaggag actagaattt cacccagtgg aattgattca gctacaaccg tggctgcagc      240

aactgctgct gccattgcaa ccgcagctcc gttgataaag gtgcagagtg atttggaagc      300

aaaagtcaat tctgttacag aattacttag taaattacag gagactgata aacacctgca      360

acgtgttaca gagcagcaaa caagcattca gaggaaacaa gagaaattac attgtcatga      420

tcacgaaaag caaatgaatg tgtttatgga gcagcacata aggcatcttg aaaagttaca      480

acaacaacaa atagatattc agactcattt tattagtgct gcactcaaga ctagtagttt      540

tcagcctgtt agtatgccct cctccagagc agtggaaaag tattccgtaa aaccagaaca      600

ccctaatctt ggtagctgta atccatcttt atataacaca tttgcttcca aacaagcacc      660

tttaaaagaa gttgaagata cgagttttga taaacagaaa tctcctttgg agacaccagc      720

acctcgcaga tttgctcctg tacctgtttc aagggatgat gaactatcaa agagggaaaa      780

tcttttggaa gaaaaagaaa atatggaagt gtcgtgtcac agaggaaatg taagactatt      840

ggaacaaatt ttgaataata atgattcttt gacaagaaaa agtgaatcat caaacaccac      900

ctcactaact aggtcaaaaa taggatggac tcctgagaaa acaaacagat ttccttcctg      960

tgaagagcta gaaacaacta aagtgactat gcagaagtct gatgatgttc ttcatgacct     1020

tggccaaaaa gagaaagaaa caaatagcat ggtccagcca aaagaatctc tgagtatgtt     1080

gaagcttcca gatcttccac agaattctgt taagcttcaa acaaccaata caacaagatc     1140

tgtattgaaa gatgctgaga agattttgag aggagtacaa aacaataaaa aagtacttga     1200

agaaaacctg gaagctatta ttcgtgcaaa agatggagct gccatgtatt cgcttatcaa     1260

tgctttatct accaacagag agatgtcaga gaaaattagg atcagaaaga cagtggatga     1320

atggattaaa actatttctg cagaaattca ggatgaactg tcaagaacag attatgaaca     1380

aaaaagattt gatcagaaga atcagagaac caagaaaggt cagaatatga ctaaagatat     1440

tagaaccaac acacaagata aaactgtcaa caaatctgta attccaagaa aacattctca     1500

aaagcaaata gaagagcatt ttagaaatct acctatgagg ggcatgcctg cttcaagttt     1560

acagaaagag agaaaggaag ggcttttgaa agcaaccaca gtaatacaag atgaagatta     1620

tatgttacaa gtctatggaa agccagttta tcagggccat cgaagcactc ttaaaaaagg     1680

accatatctc agatttaatt ctccatctcc taagtccaga ccacagagac caaaagtaat     1740

agaacgagtt aaaggcacta aggtaaagtc aataagaaca cagactgact tctatgcaac     1800

aaaacctaag aagatggatt ctaaaatgaa acattctgtt cctgtgttac ctcatggcga     1860

tcagcaatat ttgttcagcc caagtagaga aatgcctact ttttcaggta cattggaagg     1920

tcatctgatt cctatggcaa ttcttttagg acaaacccaa agtaatagtg ataccatgcc     1980

acctgctgga gtgattgtca gcaagccaca ccctgtaact gtgactactt ctattcctcc     2040

atcatctcga aaagtagaaa ctggagtaaa gaaacctaac atagccattg tagaaatgaa     2100

gtcagaaaaa aaggatcctc ctcagcttac tgtgcaggta ttacccagtg tagatattga     2160

cagcatttca aatagtagtg ctgatgtcct ttcacctctg tctagcccca aagaagcatc     2220

tcttcctcct gtgcaaactt ggataaagac tccagaaatt atgaaggtag atgaagaaga     2280

ggtgaagttt ccaggaacta actttgatga aataatcgat gtcatacagg aagaagaaaa     2340

atgtgatgaa attccagact ctgaaccaat tctggagttt aacagaagtg ttaaagctga     2400

ttctacaaaa tataatggtc ctccatttcc gccagttgct tctacttttc agcccactgc     2460

tgatattctg gataaagtaa ttgagagaaa agaaacactg gaaaatagct taattcaatg     2520

ggtagagcaa gaaataatgt caagaattat ctctgggctc tttccagtcc agcaacagat     2580

tgcacctagt atcagtgttt cagtcagtga gacaagtgaa ccactgactt ctgacattgt     2640

ggaaggaaca agcagtggcg ccctccagct ttttgttgat gctggtgttc ctgtgaactc     2700

aaatgtgatt aaacattttg ttaacgaagc tcttgctgag accattgctg tcatgctggg     2760

tgacagagaa gcaaagaagc aaggtcctgt tgctacaggt gtttctgggg atgcttcaac     2820

aaatgaaaca tatttgccgg caagagtgtg caccccactg cctaccccac agcctacgcc     2880

tccttgctca ccttcatcac ctgctaagga gtgtgttttg gtaaagactc cagattcttc     2940

tccctgtgat tcggatcatg atatggcttt tcctgtgaaa gaaatatgtg ctgaaaaagg     3000

agatgatatg cctgccatca tgcttgttaa tactccaaca gttaccccta ctactacacc     3060

tcctccagcg gcggcagttt ttaccccaac tttgtcagat atttccattg ataaattgaa     3120

ggtatcaagc ccagagcttc ccaagccatg gggtgatgga gacctgccac tggaagaaga     3180

gaaccctaac tcacctcaag aagaacttca tccaagagct atgtaaatga gaacatactc     3240

actagtaact gtacatttca acttatgttt gacttatgtg atccattgaa aacatagaaa     3300

tattatacaa agctttataa accacagact accttatact ttgaaagaaa gaactttcat     3360

aagtgttgag ttttgaaaaa ttatcaaatt ataccttcac cttttttctt aaaaggtttg     3420

aaatagctag aaataaaggt atctattata ttgttaataa aatagaaaac aatttc         3476


<210> 4477
<211> 3923
<212> DNA
<213> Homo sapiens

<400> 4477
agcagtagcg gcagccctga ggacgatatg gtgtaagata cttcttcaag attggacagc       60

tggggacctt cttctgatta accttaaacc aacttgtagc catagagaca cctcacaagg      120

ttcccatttt tgttgttgtt gttgttgatt ttctgctcac acctttcctg accttgcaac      180

catgtatgga agtgcccgct ctgttgggaa ggtggagccg agcagccaga gccctgggcg      240

ttcacccagg cttccacgtt cccctcgctt gggtcaccgt cgaaccaaca gtacgggagg      300

gagttcggga agcagtgttg gaggtggcag tgggaaaacc ctttcaatgg aaaatataca      360

atctttaaat gctgcctatg ccacctctgg ccctatgtat ctaagtgacc atgaaaatgt      420

gggttcagaa acacctaaaa gcaccatgac acttggccgt tctgggggac gtctgcctta      480

cggtgttcgg atgactgcta tgggtagtag ccccaatata gctagcagtg gggttgctag      540

tgacaccata gcatttggag agcatcacct ccctcctgtg agtatggcat ccactgtacc      600

tcactccctt cgtcaggcga gagataacac aatcatggat ctgcagacac agctgaagga      660

agtattaaga gaaaatgatc tcttgcggaa ggatgtggaa gtaaaggaga gcaaattgag      720

ttcttcaatg aatagcatca agaccttctg gagcccagag ctgaagaagg aacgagccct      780

gagaaaagat gaagcttcca aaatcaccat ttggaaggaa cagtacagag ttgtacagga      840

ggaaaaccag cacatgcaga tgacaatcca ggctctccag gatgaattgc ggatccagag      900

ggacctgaat cagctgtttc agcaggatag tagcagcagg actggcgaac cttgtgtagc      960

agagctgaca gaggagaact ttcagaggct tcatgctgag catgagcggc aggccaaaga     1020

gctgtttctt cttcgaaaga cattggagga aatggagctg cgtattgaga ctcaaaagca     1080

gaccctaaat gctcgggatg aatccattaa gaagcttctg gaaatgttgc agagcaaagg     1140

actttctgcc aaggctaccg aggaagacca tgagagaaca agacgactgg cagaggcaga     1200

gatgcacgtt catcacctag aaagcctttt ggagcagaag gaaaaagaga acagtatgtt     1260

gagagaggag atgcatcgaa ggtttgagaa tgctcctgat tctgccaaaa caaaagctct     1320

gcaaactgtt attgagatga aggattcaaa aatttcctct atggagcgtg ggcttcgaga     1380

cctggaagag gaaattcaga tgctgaaatc gaatggtgct ttgagtactg aggaaaggga     1440

agaagaaatg aagcaaatgg aagtgtatcg gagccattct aaatttatga aaaataaggt     1500

agaacaactg aaggaggaac taagttcgaa agaggctcaa tgggaggagc tgaaaaagaa     1560

agcggctggt cttcaggctg agattggcca ggtgaaacag gagctgtcca gaaaggacac     1620

agaactactc gccctgcaga caaagctaga aacactcaca aaccagttct cagatagtaa     1680

acagcacatt gaagtgttga aggagtcctt gactgctaag gagcagaggg ctgccatcct     1740

gcagactgag gtggatgctc tccgattgcg tttggaagag aaggaaacca tgttgaataa     1800

aaagacaaaa caaattcagg atatggctga agagaagggg acacaagctg gagagataca     1860

tgacctcaag gacatgttgg atgtgaagga gcggaaggtt aatgttcttc agaagaagat     1920

tgaaaatctt caagagcagc ttagagacaa ggaaaagcag atgagcagct tgaaagaacg     1980

ggtcaaatcc ttgcaggctg acaccaccaa cactgacact gccttgacaa ctttggagga     2040

ggcccttgca gagaaagagc ggacaattga acgcttaaag gagcagaggg acagagatga     2100

gcgagagaag caagaggaaa ttgataacta caaaaaagat cttaaagact tgaaggaaaa     2160

agtcagcctg ttgcaaggcg acctttcaga gaaagaggct tcacttttgg atctgaaaga     2220

gcatgcttct tctctggcat cctcaggact gaaaaaggac tcacggctta agacactaga     2280

gattgctttg gagcagaaga aggaggagtg tctgaaaatg gaatcacaat tgaaaaaggc     2340

acatgaggca gcattggaag ccagagccag tccagagatg agtgaccgaa tacagcactt     2400

ggagagagag atcaccaggt acaaagatga atctagcaag gcccaggcag aagttgatcg     2460

actcttagaa atcttgaagg aggtggaaaa tgagaagaat gacaaagata agaagatagc     2520

tgagttggaa aggcaagtga aagaccagaa taagaaggta gcaaatctga agcacaagga     2580

acaggtggaa aaaaagaaga gtgcacaaat gttagaggag gcgcgacgac gggaggacaa     2640

tctcaacgac agctctcagc agctacagga cagtctccgt aagaaggatg acaggattga     2700

agagctggaa gaagcactaa gagaaagtgt acagataact gcagagcggg aaatggtgct     2760

agcacaagag gaatcagcca ggaccaatgc tgaaaaacag gtggaggagt tactgatggc     2820

catggagaag gtaaagcagg aactagaatc catgaaagca aagctgtcct ccacccagca     2880

gtctctggca gaaaaggaaa ctcacttgac taatcttcgg gcagagagaa ggaaacactt     2940

agaggaagtt ctggagatga agcaagaagc tcttctggct gccattagtg aaaaagacgc     3000

caatatagct ctcttggagc tttcgtcctc taagaagaag acccaagagg aagtggctgc     3060

cctgaagcgg gagaaggatc gtctggtaca gcagcttaag cagcagacgc aaaatcgaat     3120

gaagctaatg gccgacaact acgaggatga ccacttcaaa tcctcccatt ccaatcaaac     3180

aaatcacaag ccctccccag accagatcat ccagcccctc ttagaacttg accaaaatag     3240

aagtaaatta aagttgtaca ttggacacct gacaaccctc tgccatgacc gagaccccct     3300

gatcctccgt ggactcactc caccagcttc ctataacttg gacgatgacc aggcggcttg     3360

ggagaatgag ctgcagaaga tgacccgggg gcagcttcag gatgagttag agaaaggtga     3420

acgggacaat gcagaactgc aggagtttgc caacgccatt cttcagcaga tagcagacca     3480

ttgtcccgac atcctagagc aagtggtcaa cgccctggaa gagtcctctt gaccctgctt     3540

tatggggaag cctgaggtag tcaacccagg agccaagaaa agagaactac gaggaacagg     3600

tgcccggaac cttcttggca ccaaacacta caaacttcat cccaacttgc tcacttgaag     3660

aagtgtgatt ccagcaccgt ttctacatct gccatcttac tctgcctttc tgctttggat     3720

gtggtctcta cactaacctt cttgatgtcc agggtagata aagggtcgaa tctctctgaa     3780

gaactgccac ctggtcatca gcagtggaga actgtgggag ctggtggctc tgccctgaca     3840

gagagccatg gagcagagga gcctctcacc tcctgtcctc tgacatgaga atgaaaccag     3900

gaatggactt ggagttcaac agg                                             3923


<210> 4478
<211> 1662
<212> DNA
<213> Homo sapiens

<400> 4478
gacgtacctc acggaagccg gctttggccc tgcggctgct accgtcgccg cggagaaatt       60

gttggatctg gcagtctagg aatggttcat caagaggaag aagttcgatg atgagctggt      120

ggagagcagc ctggcaaaat cttctacccg ggcaaagggg gccagtgggg tggaaccagg      180

gcgctgttcg gggagtgaac cctcctccag tgagaagaag aaggtatcca aagcccccag      240

cactcctgtg ccacccagcc cagccccagc ccctggactc accaagcgtg tgaagaagag      300

taaacagcca cttcaggtga ccaaggatct gggccgctgg aagcctgcag atgacctcct      360

gctcataaat gctgtgttgc agaccaacga cctgacctcc gtccacctgg gcgtgaaatt      420

cagctgccgc ttcacccttc gggaggtcca ggagcgttgg tacgccctgc tctacgatcc      480

tgtcatctcc aagttggcct gtcaggccat gaggcagctg cacccagagg ctattgcagc      540

catccagagc aaggccctgt ttagcaaggc tgaggagcag ctgctgagca aagtgggatc      600

gaccagccag cccaccttgg agaccttcca ggacctgctg cacagacacc ctgatgcctt      660

ctacctggcc cgtaccgcga aggccctgca ggcccactgg cagctcatga agcagtatta      720

cctgctggag gaccagacag tgcagccgct gcccaaaggg gaccaagtgc tgaacttctc      780

tgatgcagag gacctgattg atgacagtaa gctcaaggac atgcgagatg aggtcctgga      840

acatgagctg atggtggctg accggcgcca gaagcgagag attcggcagc tggaacagga      900

actgcataag tggcaggtgc tagtggacag catcacaggc atgagctctc cggacttcga      960

caaccagaca ctggcagtgc tgcggggccg catggtgcgg tacctgatgc gctcgcgtga     1020

gatcaccctg ggcagagcaa ccaaggataa ccagattgat gtggacctgt ctctggaggg     1080

tccggcctgg aagatatccc ggaaacaagg tgtcatcaag ctgaagaaca acggtgattt     1140

cttcattgcc aatgagggtc gacggcccat ctacatcgat ggacggccgg tgctctgtgg     1200

ctccaaatgg cgcctcagca acaactctgt ggtggagatc gccagcctgc gattcgtctt     1260

ccttatcaac caggacctca ttgccctcat cagggctgag gctgccaaga tcacaccaca     1320

gtgaggagtg gtggcaggac tcgtgggccc tctccggcct gtttcccctg ccactccagc     1380

ccccttgagc tgggaactca ggctcctgga aaaacctggg cagtgggagg ctcagctgcg     1440

ggccattgat ttgagccttt gagggaggat agggctggcc tttgtgaagc cagcagaggc     1500

tgagaacctc aggcttccct agatccagag cccctcccca tcttcctctc tctaaaaaca     1560

accctacccc ccattgccac cttcactcct gtgtctccag ctgattagcc tcagactctt     1620

cttttattgt ttttcttttg taaataaaaa gcaccaggtt cc                        1662


<210> 4479
<211> 4173
<212> DNA
<213> Homo sapiens

<400> 4479
ggagtttccc agcgacggcc gtaagtggcg ggcggaagcg gccctagaag cccgccgtaa       60

acggctccct cgcgccactt ccggccggct tccgcagacg gcgctggtgg tcgatcgtgt      120

ggcgccggag gacgttcccc gcggccggag ccatggagat gccgctgccc cccgatgacc      180

aggagcttcg aaatgtcatc gacaagctcg cccagttcgt ggctcgcaat gggcccgagt      240

ttgagaagat gactatggag aagcagaagg acaaccccaa attctcgttt cttttcggag      300

gcgaattcta cagttactac aagtgcaagc tggcgctgga gcagcagcag ctcatctgca      360

agcagcagac cccggagctg gagccagccg ccaccatgcc acccctgcca cagcccccgc      420

tggcccccgc cgcgcccatc ccgccggccc agggcgcgcc atccatggac gagctcatcc      480

agcagagcca gtggaacctc cagcagcagg agcagcactt gctggcgctc agacaggagc      540

aagtgacagc ggccgtggcc cacgcggtgg agcagcagat gcagaagctt ctggaggaga      600

cccagctaga catgaacgag tttgacaacc tcctgcagcc catcatcgac acgtgcacca      660

aggacgccat ctcggccggg aagaactgga tgttcagcaa tgccaagtcc ccgccgcact      720

gtgagctgat ggccggccac ctccggaacc gcatcacggc tgatggggca cacttcgagc      780

tgcggctgca cctcatctac ctgatcaatg acgtgctgca ccactgccag cgcaagcagg      840

cccgggagct gctggccgcc ctgcagaagg tcgtggtgcc catctactgc accagcttct      900

tggccgtgga ggaagacaag cagcagaaga tcgcccggct cctgcagctc tgggagaaaa      960

acggctactt cgatgactcc atcattcagc agctacagag cccagccctg gggcttggtc     1020

agtaccaggc caccctcatc aacgagtact cctcagtggt ccagccggtg cagctggcct     1080

tccagcagca gatccagacc ctcaagacgc agcacgagga gtttgtcacc agcctggccc     1140

agcagcagca gcagcagcaa cagcagcagc agcagctcca gatgccgcag atggaggctg     1200

aagtcaaggc cacgcctcca ccgcctgctc cacccccggc cccagcacct gcccctgcca     1260

tcccgcccac cacccagcct gatgacagca agcctcccat ccagatgcct ggctcttcag     1320

agtacgaagc tccaggaggg gtccaggatc ctgcagctgc cggcccccgg ggccccgggc     1380

cacacgacca gatcccacca aacaagcccc cttggtttga ccagcctcac cccgtggctc     1440

cttggggcca gcagcagccg ccagagcagc caccctaccc gcaccaccag ggcggcccac     1500

cccactgccc cccctggaac aacagccatg agggcatgtg gggcgagcag cgcggtgacc     1560

ccggctggaa cggccagcgc gacgcgccct ggaacaacca gcccgacgcc gcctggaaca     1620

gccagttcga gggcccctgg aacagccagc acgagcagcc gccctggggc gggggccagc     1680

gcgagccacc cttccgcatg cagcggcccc cacacttccg ggggcccttc ccgccccacc     1740

agcagcaccc gcagttcaac cagcctccgc acccccacaa cttcaaccgc ttcccgcccc     1800

gcttcatgca ggacgacttc ccgccacggc accccttcga gcggccgccc tatccccacc     1860

gcttcgacta cccccagggg gacttccctg ccgaaatggg gccccctcac caccaccctg     1920

gccaccgcat gcctcatcct ggcatcaacg agcacccgcc ttgggctgga ccccagcacc     1980

ctgacttcgg ccctcccccc catggcttca acgggcagcc cccacacatg cggcgacagg     2040

gcccacccca catcaaccac gatgacccca gcctggtccc caatgtgccc tacttcgatc     2100

tccctgctgg gctgatggcc cccctcgtga agctggaaga tcacgagtac aagcctttgg     2160

accctaaaga catccgcctc ccacccccca tgccgcccag cgagaggctg ctggctgcag     2220

tggaggcctt ctacagcccc ccgtcccacg acaggcccag gaacagtgaa ggctgggagc     2280

agaacggcct ctatgagttc ttccgagcaa aaatgcgggc ccggcggagg aaaggccagg     2340

agaagaggaa cagcggaccc tcgaggtctc ggagcagatc caagagtcga gggcgttctt     2400

cctcccgctc caactcaaga tcctccaagt cttcaggctc gtactcaagg tcaaggtcgc     2460

gctcctgctc ccgttcctac tcccgctcca gatctagaag tcggagcagg tcgcgctcct     2520

ccagaagccg ctcccggtcc cagtcgcggt cccggtccaa gtcgtactcc ccaggaagaa     2580

gacgccggtc acggtccagg agccccaccc cgccttcctc tgctggtctg ggttctaatt     2640

cggcgcctcc catccctgac tcaaggctcg gagaagagaa caaaggccat cagatgctgg     2700

tgaagatggg ctggagcggc tcaggcggcc tcggtgcgaa ggagcaaggg atccaggacc     2760

ccatcaaggg cggggacgtc cgggataagt gggaccagta taaaggcgtg ggcgtggctc     2820

tggatgaccc ctatgagaac taccgcagga acaagagcta ctccttcatc gcccgcatga     2880

aggccaggga cgagtgtaag taggcgccca tgccgggagc cgcgccggtg gccagcggtg     2940

ccggctgtgg gaccttcctg gctgactggc agaggaagat tgcagtgaca gctcagttct     3000

tacaccgtct ccacttgtgg agagccacag gaagagaagg aagaccagcg catgcccagt     3060

gggaacgccg tgctccatgg cgtggagggc acgggtgcca cccacaaacc acaccaggag     3120

gcgctgcagc caccagggcc ccaggctcgt tttcctttat agcgaagcaa aaaacacaag     3180

accctccgcc cgagtaaatt cttcagccac gaagggatgg atgtgcatct gccctaagtc     3240

agattgaagc ctcctcctag gctccaggag gagcatgtgc aggaagggtt ggcctgagcc     3300

agagccggca ccccagctcc ttcctccagc tccccgcacc caccggccct gacctggctt     3360

cccctcggct gtgtagggac aaagccgaag cccagtgcca tgactgcccg cggattgaaa     3420

aacagaaaca caaaactttg acttgacttg cgaagtgaag cagggttttc atttttactc     3480

tccttggttt aggtctagaa agaagaatac tgacctgaga ggaggcccag tgagattctg     3540

aaacctaatt cttcgaaggc gtactggccc ttagttcagt tattttagtt gtataagttg     3600

atattttttt tctggaatgt agccatttgc tgttatctgg gaaacaagat tctaacagga     3660

aaccagccta agacacttca ggttgagcgc tgcctcggag tctgtgcccg tcgcgtcccc     3720

tgcttgagtt ttgcacttgg aagaaccctg caccggctgg cgtgtgcgac ggcccagtcc     3780

catccagagc atggagcccg accccagcca gcgccttcca ctccatcatt tcatttcaca     3840

cccccgaagg gaggggaggc caggagggga gctgctcctg ccagaagctg gtgggtgacc     3900

gttgggaatc ggccacacct ggtgtccatg ggcagcctgg tgcaattcca ttcatttgta     3960

cagaaacatt tttgaaaaat tcttttcaat aagatgcaaa atcttccaac ttttcaaccc     4020

aacgtgatga atatttgatt ttgttctaga tttcctgtag ctgtgaattg ttaaaatgta     4080

tgattcagga taaaacgtaa acacgtgctg ttagtaattt cttgtggatt tcattgtttt     4140

gccttcaaat aaagcctttt tttaaagacc ttt                                  4173


<210> 4480
<211> 4121
<212> DNA
<213> Homo sapiens

<400> 4480
aaagctagga caaactcccg ccaacacgca ggcgccgtag gttcactgcc tactcctgcc       60

cgccatttca cgtgttctca gaggcaggtg gaacttctta atgcgcctgc gcaaaactcg      120

ccattttact acacgtgcgg tcaacaagag ttcattgcaa aaaaattgtt acctcctggc      180

tgcttgtcta atacatagtg ttaatcatgc tttgccaagc gacttgactg taatatttgc      240

gcgtggaaga ttaaaaagat gttaaacacc caaggtagat tcaaatgtga atgattggtc      300

ggttggccaa tcagactggt taacaataac attactcggg aaccaatgga ctccaagggg      360

tggagacggc gtagaacgac cgaaggaatg acgttacaca gcaatgtggc accacaggcc      420

aatagcaggg ggaagcgatt tcaagtatcc aatcagagct gttccagggc ggagtctacc      480

aatgccgaaa gcgaggaggc ggggtaaaaa agagagggcg aaggtaggct ggcagatacg      540

ttcgtcagct tgctcctttc tgcccgtgga cgccgccgaa gaagcatcgt taaagtctct      600

cttcaccctg ccgtcatgtc taagtcagag tctcctaaag agcccgaaca gctgaggaag      660

ctcttcattg gagggttgag ctttgaaaca actgatgaga gcctgaggag ccattttgag      720

caatggggaa cgctcacgga ctgtgtggta atgagagatc caaacaccaa gcgctccagg      780

ggctttgggt ttgtcacata tgccactgtg gaggaggtgg atgcagctat gaatgcaagg      840

ccacacaagg tggatggaag agttgtggaa ccaaagagag ctgtctccag agaagattct      900

caaagaccag gtgcccactt aactgtgaaa aagatatttg ttggtggcat taaagaagac      960

actgaagaac atcacctaag agattatttt gaacagtatg gaaaaattga agtgattgaa     1020

atcatgactg accgaggcag tggcaagaaa aggggctttg cctttgtaac ctttgacgac     1080

catgactccg tggataagat tgtcattcag aaataccata ctgtgaatgg ccacaactgt     1140

gaagttagaa aagccctgtc aaagcaagag atggctagtg cttcatccag ccaaagaggt     1200

cgaagtggtt ctggaaactt tggtggtggt cgtggaggtg gtttcggtgg gaatgacaac     1260

ttcggtcgtg gaggaaactt cagtggtcgt ggtggctttg gtggcagccg tggtggtggt     1320

ggatatggtg gcagtgggga tggctataat ggatttggta atgatggaag caattttgga     1380

ggtggtggaa gctacaatga ttttgggaat tacaacaatc agtcttcaaa ttttggaccc     1440

atgaagggag gaaattttgg aggcagaagc tctggcccct atggcggtgg aggccaatac     1500

tttgcaaaac cacgaaacca aggtggctat ggcggttcca gcagcagcag tagctatggc     1560

agtggcagaa gattttaatt aggaaacaaa gcttagcagg agaggagagc cagagaagtg     1620

acagggaagc tacaggttac aacagatttg tgaactcagc caagcacagt ggtggcaggg     1680

cctagctgct acaaagaaga catgttttag acaaatactc atgtgtatgg gcaaaaaact     1740

cgaggactgt atttgtgact aattgtataa caggttattt tagtttctgt tctgtggaaa     1800

gtgtaaagca ttccaacaaa gggttttaat gtagattttt ttttttgcac cccatgctgt     1860

tgattgctaa atgtaacagt ctgatcgtga cgctgaataa atgtcttttt tttaatgtgc     1920

tgtgtaaagt tagtctactc ttaagccatc ttggtaaatt tccccaacag tgtgaagtta     1980

gaattccttc agggtgatgc caggttctat ttggaattta tatacaacct gcttgggtgg     2040

agaagccatt gtcttcggaa accttggtgt agttgaactg atagttactg ttgtgacctg     2100

aagttcacca ttaaaaggga ttacccaagc aaaatcatgg aatggttata aaagtgattg     2160

ttggcacatc ctatgcaata tatctaaatt gaataatggt accagataaa attatagatg     2220

ggaatgaagc ttgtgtatcc attatcatgt gtaatcaata aacgatttaa ttctcttgaa     2280

tgaaatgaca actgtatgga tttgggactg gcagagattt ggactttccc tacccactcc     2340

ccctgataat aatgttgaat gcttctatca caattcaagt tcaaagctct gccagggaat     2400

agaaactagc tgctggctaa tgccgctcca taaatccgca gatttgaagt gtctgggagg     2460

ccttttaaaa ataactaata tcagaaagca ttttaatgaa cgtaaagata ggcttacatt     2520

aaaggaaaac tgcagtttga ctgggttctg gttgggtggg ccttcagagg ttctatcagt     2580

taactatact aattaatttg gagattcaaa ccataccaat agaaactaaa tttttctaca     2640

taatttcatg ttaactgcag tttcccttta tggcacaagg ggtcacacaa cctacctaaa     2700

atgttaattg tatagaaaat gatttctaaa cctttaacag ttaatatcca ataatgtgtt     2760

atttgtacat agattctttt gagccttacc tttggtgctc tctcaatttc agtgctattg     2820

tacctagtag catagagatt tgtctatcaa taggactgta tattccatcc catgggtgtg     2880

ttggaagttt ggggaggagg agggtggtgg gaggtgggtg ggaggtggtg gtgggtggga     2940

aagcatgggt gatagttcca tgatactggc tgagtttgca atagcaggtg gaaccctaac     3000

tattgaggga gtttgcagat acctcaggat tcgtgacaat gcctttaaag atccaggaga     3060

gatgttcagc tactaggaac tgctagcaag tatagcgcga atggctccga gctcagacac     3120

tctacagctg agagtagaca cttgtggtat gtggagtaca gataagccag gggcaggcca     3180

cggcacgctc catgaaagct aggagggagt gaaatatcag tgatcatcgc aaggaaggag     3240

gcagacaaga gtaaggcaca cctgactctt aggactagca gtcagaacca ggaggaaagg     3300

ttttattgct atgcgggtag gtaagaacag attttactta catccatata gttacttaaa     3360

gtccagtttt ctgttaaaca tttttcttaa tatattgagc caaaactagt ccagttaagc     3420

tgaacttggt ttttctggag atgaattgtt ttaaattgac accctattga tggctcccag     3480

ttgaaggaag tgagcacatt atttgtactg tgaatataaa tttttgccct tttatttatc     3540

ttcctttgac ccatttcctt aaaataatgg ctcaaagtaa tagacttccc caaatggtgg     3600

ggggatgggt gggttattaa tgggaggtat ggggggttta gcttgagatg ggacttggtc     3660

ttagagctag ttctaaaggt tgtttacttt tctagggagg agtctgctac tagtcttatc     3720

agctcttaaa aacagaaact catctgtcca agttcgtggc agaaaggtaa gtttttacaa     3780

attagtgctc agcaaaagaa tgccctgcgt tcccaaagta aaagaatgac aagctgtacc     3840

ttaaaccaaa acacttcgta atctcatcca attgcaaaaa gagttattag ccaaccaggt     3900

attcccagta gtgacagtgg atataactgt gtagtcattc acctctgctt atatgaatac     3960

tttacaacct cttttgcctt ttgcaggaac gtccttgtga agacctttat ctgagccact     4020

gtacttcgtt atcactgcca tgcagtttac atgagctgtt ctgcagctca aattccattt     4080

tgtgaatggg tttttttttt taataaactg tatttaactt a                         4121


<210> 4481
<211> 2423
<212> DNA
<213> Homo sapiens

<400> 4481
aattaaagga gtcgggtctc taactgttga tctgtttttt tcccttctga gcaatggagc       60

ttaccatctt tatcctgaga ctggccattt acatcctgac atttcccttg tacctgctga      120

actttctggg cttgtggagc tggatatgca aaaaatggtt cccctacttc ttggtgaggt      180

tcactgtgat atacaacgaa cagatggcaa gcaagaagcg ggagctcttc agtaacctgc      240

aggagtttgc gggcccctcc gggaaactct ccctgctgga agtgggctgt ggcacggggg      300

ccaacttcaa gttctaccca cctgggtgca gggtgacctg tattgacccc aaccccaact      360

ttgagaagtt tttgatcaag agcattgcag agaaccgaca cctgcagttt gagcgctttg      420

tggtagctgc cggggagaac atgcaccagg tggctgatgg ctctgtggat gtggtggtct      480

gcaccctggt gctgtgctct gtgaagaacc aggagcggat tctccgcgag gtgtgcagag      540

tgctgagacc gggaggggct ttctatttca tggagcatgt ggcagctgag tgttcgactt      600

ggaattactt ctggcaacaa gtcctggatc ctgcctggca ccttctgttt gatgggtgca      660

acctgaccag agagagctgg aaggccctgg agcgggccag cttctctaag ctgaagctgc      720

agcacatcca ggccccactg tcctgggagt tggtgcgccc tcatatctat ggatatgctg      780

tgaaatagtg tgagctggca gttaagagct gaatggctca aagaatttaa agcttcagtt      840

ttacatttaa aatgctaagt gggagaagag aaaccttttt tttggggggc ggtttttttg      900

gtttgttgtt ggtttttttt ttttttttgg cgggaagaaa gagttttgct cttgttgccc      960

aggctggagt gcaatgacgt gatctccgct cactgcaacc tccacctcgc gggtttaagc     1020

gattcttctg cctcagcctc cctagtagct gggattacag gtgcccacca ccatgcccag     1080

ctaatttgta tttttagttg agacagggtt tcactacgtt ggccaggctg gtcttgaact     1140

cctgatctca ggcaatccac ccacctcagc ctcccaaagt gctgggatga caggcgtgag     1200

caaccgcacc cagcttaagg tttttttgtt ttgttttgag acggagtttt cgctcttgtt     1260

gcccaggctg gagtgcaatg ctgtgatctc agcttaccac aacctccacc tcccgggttc     1320

aagtgattca cctgcctcag cctcctgagt agctggtatt acaggcatgc gtcaccacgc     1380

cggctaattt tgtactttta gtagagatgg tgtttcccca cgttggtcag cctggccaac     1440

atggcaaaac cctactaaag atacaaaaaa aaaaaaaaat tagccaggcg tggtggtggg     1500

tgcctgtaat cccaggtact tggaaggctg aggcaggaga atctcttgaa cccagaaggc     1560

gaaggttgca gtgaaccgag atcatgccat tgtactctag cctgggtgac aagagcaaga     1620

ctccgtctca aaaaaaaaaa aaaaaaaaaa aagaagtaga gacagggaga cagggtctca     1680

ctgtgttgcc taggccggtc ttgaactcct gggctcaagt gattctccca ccttgacctc     1740

ctaaattgtt gggattacag gtgtgagaca gtgcacctgg ccgaaatagc tcaagtttct     1800

gaaaaacaaa tctgaatcta tttgttattc ttagcgtcac tggtctggct ttcagaatta     1860

acatacaagg ttgccacacc tagttctgcc cagctttatg tcttttattc cagtattcca     1920

ccaaagtttg ttttcctgca ttccagttct caagtcttaa gataaagatt gtacttgaca     1980

gtttagtata tccataaaac tatttgaggt ggttaaggtt cttgggttca ttttccttaa     2040

tactttgctg aatattgtag attgtaggca atgaaaaagt ctactaaatt aggaaaacct     2100

tgaataatta ggtatcctag gtaagagccc ctaaacatca agcaatctgt gagtctgtaa     2160

agaaataaat attttttgga ttattcttat ctaattccac ccctgttgga agatgatttc     2220

tttgttcttt gcaactatgg aagctgtgaa aatcatcaca agtgcctctg aaagcgagtg     2280

ttaggttggt tagagggttt aatattttct gcaatggttt gtaggaattt taataaatgt     2340

agtatatttt ctgagatgat tttgtaaaag tactatttta aatatcaaat caaccaataa     2400

attcacattt gtgttaggaa cag                                             2423


<210> 4482
<211> 4568
<212> DNA
<213> Homo sapiens

<400> 4482
agtgctcgcc cgcccgaccc cggcggctcg cgcccgggag cgccgcaggg tcgctagagt       60

cggccgcgtc ctttgtgtgg cgctcaggct gcgccgcggg gcggcgggac ggaatgtggg      120

cgctgcgggg gcttttctct cctacccgaa ctgtgggaac aatggactga aaggggaaga      180

tggattgagg ggccgagcgg ggaagcgagc tgcaccgggg aatcatgact tctgcagccg      240

agataaagaa gccaccagtg gcccccaagc ccaagtttgt tgtggcaaat aataagccag      300

ccccacctcc tattgcacct aaacccgaca ttgtgatttc tagtgttcca cagtcgacaa      360

agaaaatgaa accagcaata gccccaaaac caaaagtcct gaagacctca cctgttcgag      420

agattgggca gtcgccatca aggaaaatca tgttgaacct ggaagggcat aaacaggaat      480

tagctgaaag cactgacaac tttaattgta aatatgaagg caatcagagc aatgattata      540

tttcaccaat gtgttcctgc agttctgagt gtatccataa gctgggccat agagagaatt      600

tgtgtgtaaa gcagcttgtt ttagagcccc tggaaatgaa tgaaaattta gaaaacagta      660

aaattgatga gactttgact ataaaaacta ggagtaaatg tgatttgtat ggtgaaaaag      720

ccaagaacca gggtggggtt gttttaaagg caagcgtttt agaagaggag ctcaaagatg      780

ccttaataca ccaaatgcca ccttttattt ctgcacagaa gcacaggccc acagacagcc      840

cagaaatgaa tggtggctgt aattcaaatg gacaattcag aattgaattt gcggatttgt      900

caccttcccc atccagcttt gaaaaagttc ctgatcatca cagttgccac ttacagcttc      960

ctagtgatga atgtgaacat tttgaaactt gccaggatga cagtgaaaaa agcaataatt     1020

gctttcagtc atctgaacta gaggctctgg aaaatgggaa aaggagtact ttaatatctt     1080

cagatggagt tagtaagaaa tcagaagtca aagaccttgg tcccttagaa attcatttag     1140

taccatatac cccaaaattt ccaactccca agcccagaaa gacacgaact gctcgtctgt     1200

tacgccaaaa gtgtgtagat actcctagtg aaagcactga agaaccgggg aattcagaca     1260

gtagctcttc ctgtcttact gaaaatagtt tgaaaatcaa taaaatcagt gttctgcatc     1320

agaatgtttt gtgtaagcag gaacaggtgg ataaaatgaa gctaggaaat aaaagtgaat     1380

tgaatatgga atccaacagt gatgcacagg acttagtcaa ttcacagaaa gccatgtgta     1440

atgaaacaac ttcctttgaa aaaatggcac cttcttttga taaagactct aatttgagtt     1500

ctgacagcac aactgtagat ggttctagta tgtcgcttgc tgtggacgaa gggaccggtt     1560

ttataagatg tactgtatct atgagcctgc ctaagcagct caaattaact tgcaatgaac     1620

atttgcaatc tgggagaaac ctgggagttt ctgcccctca aatgcaaaag gaatctgtta     1680

taaaagagga aaattctcta cgaattgtcc ccaaaaaacc tcaaagacat agcttgcctg     1740

ctacaggagt gcttaaaaag gctgcctccg aggagctttt ggaaaaaagt tcttatcctt     1800

caagtgaaga aaaaagttca gagaagagtc tagaaagaaa tcaccttcag catttgtgtg     1860

cccaaaaccg tggtgtgtca tcctcctttg atatgcctaa acgggcttca gaaaagccag     1920

tgtggaagtt acctcatcct attttaccct tttcagggaa cccagaattc ttaaagtctg     1980

tcaccgtatc gtcaaacagt gagccttcaa cagccctaac caagcccaga gcaaaatcgt     2040

tatctgctat ggatgtggaa aagtgcacta agccttgcaa agactctaca aagaaaaact     2100

cttttaaaaa gttgctcagc atgaaactgt ccatctgttt catgaagagt gactttcaaa     2160

aattttggtc caagagtagc caactcggag acaccaccac aggccacctc tccagtgggg     2220

agcagaaggg gattgaaagt gattggcaag gcttgttggt aggagaggag aagagaagta     2280

aacccatcaa ggcatattcc acagaaaact atagcctgga atctcaaaag aagaggaaga     2340

agtctcgggg ccagaccagt gcagctaatg gtctgagagc tgagtctttg gatgaccaaa     2400

tgctctcccg ggagtcatca tctcaggcac cttacaagtc tgttacaagc ctctgtgcac     2460

cggagtatga aaatatacgc cattatgagg aaataccaga gtacgagaac ttgccattta     2520

ttatggctat acggaaaact caagagttgg aatggcagaa ttccagcagc atggaggacg     2580

ctgatgcaaa tgtgtatgag gtagaagagc cgtatgaagc tccagatggc cagctgcagc     2640

ttggacccag acatcagcat tccagttcag gagcatccca ggaggaacag aatgatcttg     2700

gtcttggtga ccttccctct gatgaggagg aaatcatcaa cagttctgat gaagatgatg     2760

tcagctctga gtcaagtaaa ggagagcctg acccactgga agataaacag gatgaagata     2820

atggaatgaa aagtaaagtt catcatattg ccaaggagat catgagctca gagaaagtgt     2880

ttgtggatgt gttaaaactt ttgcatattg atttccggga tgcagtagct catgcttcca     2940

ggcaacttgg gaaaccagtg attgaggacc ggattctaaa tcagatccta tactacttgc     3000

ctcagctgta tgagctcaac cgggatctct tgaaggaact ggaggaaaga atgttgcact     3060

ggactgaaca acaaagaatt gctgatatct ttgtaaagaa gggaccatat ctaaaaatgt     3120

attccacata catcaaagaa tttgataaga atatagcctt gctggatgaa cagtgcaaga     3180

aaaatccagg ttttgctgct gttgttagag aatttgagat gagccctcgc tgtgctaatc     3240

tggccctcaa gcactacctg ctcaagccgg ttcagaggat cccccagtac aggctgttgc     3300

tgacagatta tttgaagaat ctcatagaag atgctggaga ttacagagac actcaagatg     3360

cccttgctgt tgttatagag gtagccaacc acgccaatga caccatgaag caaggagaca     3420

actttcagaa acttatgcaa attcagtaca gcttaaatgg acaccatgaa attgtgcagc     3480

ctggtcgggt ttttctcaaa gaaggaattc tgatgaagct gtctcggaaa gtgatgcaac     3540

ctcgaatgtt tttcctgttt aatgatgccc tgctgtatac aacaccagtg cagtctggga     3600

tgtataaact gaacaacatg ctctcactgg ctggaatgaa ggtcagaaaa cctacccaag     3660

aagcctatca gaatgaatta aagattgaaa gtgtagaacg ttccttcatt ctctcagcca     3720

gttctgccac agaaagggat gaatggctag aagcgatttc cagggcaata gaagagtatg     3780

ccaagaaaag aatcaccttc tgtcctagta ggagtcttga tgaggcagac tcagaaaata     3840

aagaagaagt tagtcctctt ggatcgaagg ctcccatctg gattcctgat accagagcca     3900

caatgtgtat gatctgcaca agcgaattca ctctcacctg gagacgacac cactgccggg     3960

cctgtggaaa gattgtatgc caagcttgtt cgtctaataa gtatggctta gattacctga     4020

aaaatcaacc agcaagagta tgtgaacatt gtttccaaga actgcagaaa ttagatcacc     4080

agcactcccc taggattgga tctcctggaa atcacaaatc tccttcaagt gccttatcat     4140

cagtcttaca tagcattcca tcagggagga aacagaaaaa aatcccagct gctctcaaag     4200

aagtatcagc aaacacagag gattcttcta tgagtggcta cttgtacaga tcaaagggca     4260

ataaaaaacc ctggaaacac ttttggtttg tcataaaaaa taaagtacta tatacatatg     4320

ctgcaagtga ggtaagatct gaaatctaaa gatgagtaat ttggggtttt gtaatgccaa     4380

ctgcaagtaa ttacaatatt ttaaaaatcc atttatttta cataagattt tttgctttgc     4440

ttttggatgg gggaggtgtt gttgctgtta tttttaatgt gaacagtgtt cttgctttgt     4500

acctggagag ctctttctca aatgtgttag gaattttcca tattattaaa atgcaatttt     4560

tgtgtgtg                                                              4568


<210> 4483
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 4483
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaatctgc ctaatcacct ggttatcccc acagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct ga                                              1522


<210> 4484
<211> 574
<212> DNA
<213> Homo sapiens

<400> 4484
gaagtgaagg gtggcccagg tggggccagg ctgactgaag tgagtagtgg gggtgccaga       60

ccaggtgcgt ctgccgctgg attgtgatag gaagcagagt gttcgtgtga tggatactat      120

gatgctgaat gtgcggaatc tgtttgagca gcttgtgcgc cgggtggaga ttctcagtga      180

aggaaatgaa gtccaattta tccagttggc gaaggacttt gaggatttcc gtaaaaagtg      240

gcagaggact gaccatgagc tggggaaata caaggatctt ttgatgaaag cagagactga      300

gcgaagtgct ctggatgtta agctgaagca tgcacgtaat caggtggatg tagagatcaa      360

acggagacag agagctgagg ctgactgcga aaagctggaa cgacagattc agctgattcg      420

agagatgctc atgtgtgaca catctggcag cattcaacta agcgaggagc aaaaatcagc      480

tctggctttt ctcaacagag gccaaccatc cagcagcaat gctgggaaca aaagactatc      540

aaccattgat gaatctggtt ccattttatc agat                                  574


<210> 4485
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4485
ggagctgtgg gcgcggcgct gctctgccgt tgggtgaggc gcggagcgaa gtgaagggtg       60

gcccaggtgg ggccaggctg actgaagaga gccaaaggaa atcaacattt gaattgacta      120

cccaatgtcc tgcccctgtt tctgtcctgt agcacttagg aaagatggat actatgatgc      180

tgaatgtgcg gaatctgttt gagcagcttg tgcgccgggt ggagattctc agtgaaggaa      240

atgaagtcca atttatccag ttggcgaagg actttgagga tttccgtaaa aagtggcaga      300

ggactgacca tgagctgggg aaatacaagg atcttttgat gaaagcagag actgagcgaa      360

gtgctctgga tgttaagctg aagcatgcac gtaatcaggt ggatgtagag atcaaacgga      420

gacagagagc tgaggctgac tgcgaaaagc tggaacgaca gattcagctg attcgagaga      480

tgctcatgtg tgacacatct ggcagcattc aactaagcga ggagcaaaaa tcagctctgg      540

cttttctcaa cagaggccaa ccatccagca gcaatgctgg g                          581


<210> 4486
<211> 3609
<212> DNA
<213> Homo sapiens

<400> 4486
ggcggggcct cctggtgagc gcgcgccggg gcggcctccg ggaagtggga gacgctgcgg       60

gtcctgggcc caggccttgg gatgggcggg aaggcttggc cgcgccgggc tgtgggcact      120

gcaggaggcc cctgtgcaga acagatctcg gcccctttcc aaacactcct gatgcctcat      180

ttgcctctcg cctcttttcg accaccattt tgggggctga ggcactcacg gggcctcccc      240

aggtttcact ccgtttctac acagtcggag ccccatggat ctcccatctc ccggaggaac      300

cgtgaagcca aacagaagcg cctgcgagag aagcaggcga ctctggaggc tgagatagca      360

ggggagagca agtcacctgc agaatccatt aaggcctgga ggcctaagga gttagtattg      420

tatgaaatcc ctacgaaacc cggtgaaaag aaagatgtct ctgggcccct gcctcctgca      480

tacagccccc gatatgttga ggctgcctgg tacccgtggt gggtacgaga gggcttcttc      540

aaaccagaat atcaggcccg gctgccccaa gctacagggg agaccttttc catgtgtatc      600

ccacctccca atgtcactgg ctccctgcac attggccacg cactcacggt ggccatacag      660

gatgccctcg tgcgctggca ccggatgcgt ggggatcaag tgctgtgggt ccctggttca      720

gatcatgcag gaattgctac acaagctgtg gtggagaaac aactgtggaa ggaacgggga      780

gtgaggagac atgagctgag ccgggaggcc ttccttaggg aggtgtggca gtggaaggag      840

gcgaaaggtg gagagatctg tgagcagctg cgagctctgg gtgcctccct ggactgggat      900

cgagagtgtt ttaccatgga tgttggctcc tcagtggctg tgactgaagc ttttgtgcgg      960

ctctacaagg cggggttgct gtaccggaac catcagcttg tcaactggtc atgtgcttta     1020

agatcagcca tctcggacat tgaggtggag aaccggcccc tgcctggcca cacacagctt     1080

cgactgcctg gctgccccac ccccgtgtct tttggcctcc tattttctgt tgccttcccc     1140

gtggatggag agcctgatgc agaggttgtg gtaggaacca caaggccaga gacgctgcct     1200

ggagatgtgg ctgtggccgt tcatccagac gactcgcgat acacacatct acacgggcga     1260

cagcttcgtc accccttgat ggggcagcct cttcccctca tcacagacta tgctgttcag     1320

ccacatgtgg gcacgggggc agtgaaggtg actccagctc acagtcctgc cgatgctgag     1380

atgggggccc gacatggctt gagccccttg aatgtcattg cggaggatgg gaccatgacc     1440

tccctctgcg gggactggct gcagggtctt caccggtttg tggcccggga aaagataatg     1500

tctgtgctga gtgaatgggg cctgttccgg ggcctccaga accaccccat ggtactgccc     1560

atctgcagcc gttctgggga tgtgatagaa tacctgctga agaaccagtg gtttgtccgc     1620

tgccaggaaa tgggggcccg agctgccaag gctgtggagt cgggggccct ggagctcagt     1680

ccctccttcc accagaagaa ctggcagcac tggttttccc atattgggga ctggtgtgtc     1740

tcccggcagc tgtggtgggg ccatcagatt ccagcctacc tggttgtaga ggaccatgcg     1800

cagggagaag aggactgttg ggtggttggg cggtcagagg ctgaggccag agaggtagca     1860

gcggaactga cagggaggcc aggggcagag ctgaccctgg agagggatcc tgatgtccta     1920

gacacatggt tttcttctgc cctgttcccc ttttctgccc tgggctggcc ccaagagacc     1980

ccagaccttg ctcgtttcta ccccctgtca cttttggaaa cgggcagcga ccttctgctg     2040

ttctgggtgg gccgcatggt catgttgggg acccagctca cagggcagct gcccttcagc     2100

aaggtgcttc ttcatcccat ggttcgggac aggcagggcc ggaagatgag caagtccctg     2160

gggaatgtgc tggacccaag agacatcatc agtggggtgg agatgcaggt gctgcaggaa     2220

aagctgagaa gcggaaattt ggaccctgca gagctggcca ttgtggctgc agcacagaaa     2280

aaggactttc ctcacgggat ccctgagtgt gggacagatg ccctgagatt cacactctgc     2340

tcccatggag ttcaggcggg cgacttgcac ctgtcagtct ctgaggtcca gagctgccga     2400

catttctgca acaagatctg gaatgctctt cgctttatcc tcaatgcttt aggggagaaa     2460

tttgtgccac agcctgctga ggagctgtct ccctcctccc cgatggatgc ctggatcctg     2520

agccgccttg ccctggctgc ccaggagtgt gagcggggct tcctcacccg agagctctcg     2580

ctcgtcactc atgccctgca ccacttctgg cttcacaacc tctgtgacgt ctacctggag     2640

gctgtgaagc ccgtgctgtg gcactcgccc cgccccctgg ggccccctca ggtcctgttc     2700

tcctgcgctg acctcggcct ccgcctcctg gccccactga tgcccttcct ggctgaagag     2760

ctctggcaga ggctgccccc caggcctggt tgcccccctg cccccagcat ctcggttgcc     2820

ccctacccca gcgcctgcag cttggagcac tggcgccagc cagagctgga gcggcgcttc     2880

tcccgggtcc aagaggtcgt gcaggtgcta agggctctcc gagccacgta ccagctcacc     2940

aaagcccggc cccgagtgct gctgcagagc tcagagcctg gggaccaggg cctcttcgag     3000

gccttcttgg agcccctggg caccctgggc tactgtgggg ctgtgggcct gttaccccca     3060

ggcgcagcag ctccctccgg ctgggcccag gctccactca gtgacacggc tcaagtctac     3120

atggagctgc agggcctggt ggacccgcag atccagctac ctctgttagc cgcccgaagg     3180

tacaagttgc agaagcagct tgacagcctc acagccagga ccccatcaga aggggaggca     3240

gggactcaga ggcaacaaaa gctttcttcc ctccagctgg aattgtcaaa actggacaag     3300

gcagcctctc acctccggca gctgatggat gagcctccag ccccagggag cccggagctc     3360

taactcatca tccccatcag ttttcctccc tctcagacct gtctttgagg acaaacagat     3420

ttgtcagctg tcagggtgca gtgggacgtc agagactatg tggtccatcg ccttcattgt     3480

gtaaatgagg acacagactg gcttggtcgc agtgactgtg gtgtccttga gatgctcaca     3540

ttactgcccg gcctgcctcc cacctggaag tctgggaatg aggagattga gataaacttt     3600

tgaaatccc                                                             3609


<210> 4487
<211> 1182
<212> DNA
<213> Homo sapiens

<400> 4487
atcagagtgc gccgtcgtcg ccgccgccac cactgtcgcc atgaacagtg tgggggaggc       60

atgcacggac atgaagcgcg agtacgacca gtgcttcaat cgctggttcg ccgagaaatt      120

tctcaagggg gacagctccg gggacccgtg caccgacctc ttcaagcgct accagcagtg      180

tgttcagaaa gcaataaagg agaaagagat tcctattgaa ggactggagt tcatgggcca      240

tggcaaagaa aagcctgaaa attcttcttg accttgacag tcaccttgaa ggatttcgca      300

agtccagaaa ttgaggactc tggatttttg tcaactaact ctgtgaacat agccatcaga      360

tttgatgagg aacttaggag agaggagttt tatttcctcc ttcgatgttt tcctctcagt      420

tgtaaaagat gaactctttg agatgatttc tcacctgctg tggtatcttg caggaactgt      480

gtgctaaaat tgaacaattt ttttgagatt atggttgcaa tacttggcgt ggaatcagct      540

ttacataaat ataccttgta tgcaaacgat gataaactag tcaggatgag cagagctgcc      600

tgacctcttg atttctgctg caaaagacat atacactgta ctggggtcac tatttatgaa      660

agcaattggt taggacctct ttttttcctc tcagggaact aatgctctga aaagggatct      720

gggcacaaca gtttcagtga gtgcttttga gcacactttt atttttatat agtaactaat      780

ggttaagatt gatggtggcc tggattagca aagaggaaga cagcttttaa cacagttccc      840

tgccttcaca agaggtgtca gattaagatg tgaaagctgc aagaatgttg cagtgaacac      900

catttcagag ctctcagtgt gcagttcagg aattaagata cttggaatag ctgtggagga      960

agaacctaaa ttgcaaagat ctgctattgc cagctctcaa cccaagtcag tgaattgtca     1020

acctgcatat cctaaaaatg tcaaaatgct gcatctggtt aaatgtcggg gtagggggga     1080

agctgaaggt gctcgcttca tttgccttgt ttactcatcc tgccctgtaa tgtctgtaat     1140

cctgaagatg gaataaattg taacatttag tttctatcat ta                        1182


<210> 4488
<211> 1825
<212> DNA
<213> Homo sapiens

<400> 4488
tgcaattaaa ggagtcgggt ctctaactgt tgatctgttt ttttcccttc tgagcaatgg       60

agcttaccat ctttatcctg agactggcca tttacatcct gacatttccc ttgtacctgc      120

tgaactttct gggcttgtgg agctggatat gcaaaaaatg gttcccctac ttcttggtga      180

ggttcactgt gatatacaac gaacagatgg caagcaagaa gcgggagctc ttcagtaacc      240

tgcaggagtt tgcgggcccc tccgggaaac tctccctgct ggaagtgggc tgtggcacgg      300

gggccaactt caagttctac ccacctgggt gcagggtgac ctgtattgac cccaacccca      360

actttgagaa gtttttgatc aagagcattg cagagaaccg acacctgcag tttgagcgct      420

ttgtggtagc tgccggggag aacatgcacc aggtggctga tggctctgtg gatgtggtgg      480

tctgcaccct ggtgctgtgc tctgtgaaga accaggagcg gattctccgc gaggtgtgca      540

gagtgctgag accgggaggg gctttctatt tcatggagca tgtggcagct gagtgttcga      600

cttggaatta cttctggcaa caagtcctgg atcctgcctg gcaccttctg tttgatgggt      660

gcaacctgac cagagagagc tggaaggccc tggagcgggc cagcttctct aagctgaagc      720

tgcagcacat ccaggcccca ctgtcctggg agttggtgcg ccctcatatc tatggatatg      780

ctgtgaaata gtgtgagctg gcagttaaga gctgaatggc tcaaagaatt taaagcttca      840

gttttacatt taaaatgcta agtgggagaa gagaaacctt ttttttgggg ggcggttttt      900

ttggtttgtt gttggttttt tttttttttt tggcaggaga atctcttgaa cccagaaggc      960

gaaggttgca gtgaaccgag atcatgccat tgtactctag cctgggtgac aagagcaaga     1020

ctccgtctca aaaaaaaaaa aaaaaaaaaa aagaagtaga gacagggaga cagggtctca     1080

ctgtgttgcc taggccggtc ttgaactcct gggctcaagt gattctccca ccttgacctc     1140

ctaaattgtt gggattacag gtgtgagaca gtgcacctgg ccgaaatagc tcaagtttct     1200

gaaaaacaaa tctgaatcta tttgttattc ttagcgtcac tggtctggct ttcagaatta     1260

acatacaagg ttgccacacc tagttctgcc cagctttatg tcttttattc cagtattcca     1320

ccaaagtttg ttttcctgca ttccagttct caagtcttaa gataaagatt gtacttgaca     1380

gtttagtata tccataaaac tatttgaggt ggttaaggtt cttgggttca ttttccttaa     1440

tactttgctg aatattgtag attgtaggca atgaaaaagt ctactaaatt aggaaaacct     1500

tgaataatta ggtatcctag gtaagagccc ctaaacatca agcaatctgt gagtctgtaa     1560

agaaataaat attttttgga ttattcttat ctaattccac ccctgttgga agatgatttc     1620

tttgttcttt gcaactatgg aagctgtgaa aatcatcaca agtgcctctg aaagcgagtg     1680

ttaggttggt tagagggttt aatattttct gcaatggttt gtaggaattt taataaatgt     1740

agtatatttt ctgagatgat tttgtaaaag tactatttta aatatcaaat caaccaataa     1800

attcacattt gtgttaggaa cagaa                                           1825


<210> 4489
<211> 1029
<212> DNA
<213> Homo sapiens

<400> 4489
gttccagggt cgggtttggt ggattcctca gtccctgccg ccgcggggcg ccctgggata       60

gcggcggggc ctcctgaaca gatctcggcc cctttccaaa cactcctgat gcctcatttg      120

cctctcgctt cttttcgacc accattttgg gggctgaggc actcacgggg cctccccagg      180

tttcactccg tttctacaca gtcggagccc catggatctc ccatctcccg gaggaaccgt      240

gaagccaaac agaagcgcct gcgagagaag caggctactc tggaggctga gatagcaggg      300

gagagcaagt cacctgcaga atccattaag gcctggaggc ctaaggagtt agtattgtat      360

gaaatcccta cgaaacccgg tgaaaagaaa gatgtctctg ggcccctgcc tcctgcatac      420

agcccccgat atgttgaggc tgcctggtac ccgtggtggg tacgagaggg cttcttcaaa      480

ccagaatatc aggcccggct gccccaagct acaggggaga ccttttccat gtgtatccca      540

cctcccaatg tcactggctc cctgcacatt ggccacgcac tcacggtggc catacaggat      600

gccctcgtgc gctggcaccg gatgcgtggg gatcaagtgc tgtgggtccc tggttcagat      660

catgcaggaa ttgctacaca agctgtggtg gagaaacaac tgtggaagga acggggagtg      720

aggagacatg agctgagccg ggaggccttc cttagggagg tgtggcagtg gaaggaggcg      780

aaaggtggag agatctgtga gcagctgcga gctctgggtg cctccctgga ctgggatcga      840

gtgttttacc atggatgttg gctcctcagt ggctgtgact gaagcttttg tgcggctcta      900

caaggcgggg ttgctgtacc ggaaccatca gcttgtcaac tggtcatgtg ctttaagatc      960

agccatctcg gacattgagg tggagaaccg gcccctgcct ggccacacac agcttcgact     1020

gcctggctg                                                             1029


<210> 4490
<211> 1539
<212> DNA
<213> Homo sapiens

<400> 4490
cgttaaagtc tctcttcacc ctgccgtcat gtctaagtca gagtctccta aagagcccga       60

acagctgagg aagctcttca ttggagggtt gagctttgaa acaactgatg agagcctgag      120

gagccatttt gagcaatggg gaacgctcac ggactgtgtg gtaatgagag atccaaacac      180

caagcgctcc aggggctttg ggtttgtcac atatgccact gtggaggagg tggatgcagc      240

tatgaatgca aggccacaca aggtggatgg aagagttgtg gaaccaaaga gagctgtctc      300

cagagaagat tctcaaagac caggtgccca cttaactgtg aaaaagatat ttgttggtgg      360

cattaaagaa gacactgaag aacatcacct aagagattat tttgaacagt atggaaaaat      420

tgaagtgatt gaaatcatga ctgaccgagg cagtggcaag aaaaggggct ttgcctttgt      480

aacctttgac gaccatgact ccgtggataa gattgtcatt cagaaatacc atactgtgaa      540

tggccacaac tgtgaagtta gaaaagccct gtcaaagcaa gagatggcta gtgcttcatc      600

cagccaaaga ggtcgaagtg gttctggaaa ctttggtggt ggaagctaca atgattttgg      660

gaattacaac aatcagtctt caaattttgg acccatgaag ggaggaaatt ttggaggcag      720

aagctctggc ccctatggcg gtggaggcca atactttgca aaaccacgaa accaaggtgg      780

ctatggcggt tccagcagca gcagtagcta tggcagtggc agaagatttt aattaggaaa      840

caaagcttag caggagagga gagccagaga agtgacaggg aagctacagg ttacaacaga      900

tttgtgaact cagccaagca cagtggtggc agggcctagc tgctacaaag aagacatgtt      960

ttagacaaat actcatgtgt atgggcaaaa aactcgagga ctgtatttgt gactaattgt     1020

ataacaggtt attttagttt ctgttctgtg gaaagtgtaa agcattccaa caaagggttt     1080

taatgtagat tttttttttt gcaccccatg ctgttgattg ctaaatgtaa cagtctgatc     1140

gtgacgctga ataaatgtct tttttttaat gtgctgtgta aagttagtct actcttaagc     1200

catcttggta aatttcccca acagtgtgaa gttagaattc cttcagggtg atgccaggtt     1260

ctatttggaa tttatataca acctgcttgg gtggagaagc cattgtcttc ggaaaccttg     1320

gtgtagttga actgatagtt actgttgtga cctgaagttc accattaaaa gggattaccc     1380

aagcaaaatc atggaatggt tataaaagtg attgttggca catcctatgc aatatatcta     1440

aattgaataa tggtaccaga taaaattata gatgggaatg aagcttgtgt atccattatc     1500

atgtgtaatc aataaacgat ttaattctct tgaatgaaa                            1539


<210> 4491
<211> 623
<212> DNA
<213> Homo sapiens

<400> 4491
gcactaagca catctacaat caaggagagg ggcaggcttt accttttgaa ggaagaagta       60

tgaaagtgta tcactgactg atcaagtaga gtaaaatgaa tgaaagtaaa cctggtgact      120

cacagaacct tgcttgtgtt ttctgtcgaa aacatgatga ctgtcctaat aaatacggag      180

aaaagaaaac taaggagaaa tggaatctca ctgtacatta ctactgtttg ttgatgtcaa      240

gtggaatttg gcagagaggc aaagaagaag aaggagttta tggttttcta atagaagata      300

tcaggaagga agtgaataga gcttctaaac tgaaatgctg tgtttgcaag aaaaatggtg      360

cttcaattgg atgtgttgca ccccgatgta aacgaagtta tcatttccca tgtggacttc      420

agagagaatg tattttccag tttactggca attttgcgtc attttgttgg gaccatcgac      480

ctgttcaaat aattacatct aataattata gagagtcctt accatgcacc atttgcttgg      540

aatttattga gcctattcca agttataaca tattacgaag tccttgttgt aagaacgctt      600

ggtttcatag agactgttta cag                                              623


<210> 4492
<211> 5298
<212> DNA
<213> Homo sapiens

<400> 4492
aacgtgatgg cgtcaggggc cggggcgccg cttcctgttg tcagtggccg agagaccgca       60

tcgtcggctc ggaggctgag gggctgccgc ggccgggagc gcccctcgcc tcgctcctcg      120

ctccgcttgg tgtcatgtga ttctctgagg gagcagctgc gtgagtggag atgctttcag      180

tggtggagaa tggactggac ccccaggctg ccatcccggt catcaagaag aagctggtgg      240

gatccgtgaa ggccttgcag aagcagtacg tgtccctgga cacggtggtc actagtgaag      300

acggagatgc caacaccatg tgcagcgccc tggaggccgt atttatccat ggcctgcacg      360

ccaagcacat ccgagctgag gccggaggaa aaaggaagaa aagtgcccac cagaagcctc      420

tgccccagcc tgtcttctgg cccctcctga aagctgtcac ccacaaacac atcatctcag      480

agttggagca cctgacgttt gtcaacacgg atgtgggccg ctgccgggca tggctgcggc      540

tggccctgaa cgatggcctg atggagtgct acctgaagct gctgctgcag gagcaggccc      600

gcttgcatga gtactaccag cccaccgccc tgctccgaga tgctgaggag ggcgagttcc      660

tccttagctt cctgcagggc ctcacgtcct tgtccttcga actctcctac aagtctgcca      720

tcttaaatga gtggacgctc accccactgg ccctgtctgg gctttgcccg ctttctgagc      780

tggaccctct ctctacctct ggtgcagaac tacagcggaa ggaatctctg gattccattt      840

cgcattcttc aggctctgaa gacatcgaag tccatcactc gggccataag atacggagga      900

accagaagct gactgcctcc tccctcagcc tggacacggc cagttcatcc cagctgtcct      960

gcagcctaaa ctctgatagc tgcttactcc aagagaatgg ctccaagagt ccagaccatt     1020

gtgaggagcc catgtcctgt gactcagacc tgggcacagc aaatgctgag gactcagacc     1080

ggtctctgca agaggtattg ttggaattca gcaaagccca ggtaaactct gtgccaacca     1140

acggactgag ccaagaaacg gagatcccca caccacaggc ctcgctctcc ctccatggcc     1200

tcaacaccag cacatacctg cactgtgagg cacctgcaga gccccttcct gcccaggcag     1260

cctctggaac tcaagatggt gtccacgtgc aggagccgcg tccccaggcg cccagccccc     1320

tggacttaca gcagcctgta gagagcacct caggccagca gccttctagt actgtcagcg     1380

agacagccag agaagtgggc caagggaatg gcctgcagaa ggcccaggct catgacggag     1440

ctggtctgaa gctggtagtt tcctcaccca ccagtccgaa aaacaagagc tggatctcag     1500

aggatgactt ctaccggcct tcccgggagc aacccctgga gagtgcttca gaccacccaa     1560

tagcttctta cagggggact ccagggtcaa ggcctggtct ccacaggcat ttttctcaag     1620

aaccaagaaa aaactgctcc ctgggggcgt tagaccaagc gtgtgtacct tccccaggaa     1680

gaaggcaagc ccaggcagcc ccatcccagg ggcataagag cttccgggtg gtacaccgga     1740

gacagatggg actgtccaac ccattccggg gtctcatgaa gctgggcacc gtggagcggc     1800

ggggggcaat gggcatctgg aaggagctct tctgcgagct ctccccgctg gagttccgcc     1860

tctacctgag caacgaggag cacacctgtg tggagaactg ctcgctgctt cgctgtgagt     1920

ctgtggggcc agcccatagt gatgggcgct ttgagctggt cttctctggc aagaagctgg     1980

ccctgcgcgc ctcctcccag gacgaagctg aggactggct ggaccgggtg cgggaggccc     2040

tgcagaaggt ccggcctcag caggaggatg agtgggtgaa cgtgcagtac ccagaccagc     2100

ctgaggaacc ccccgaggcg ccccagggct gcctctctcc ctcagacctg ctctcggagc     2160

ccgcggccct ccagggcaca cagtttgact ggtcgtccgc ccaggttcca gagccagatg     2220

ccatcaagga gtccctgctg tacttgtaca tggacaggac ctggatgccc tatatatttt     2280

ctctgtcctt ggaggctctg aaatgtttcc gcatcaggaa caatgagaag atgctgagtg     2340

acagccacgg cgtggagacc atccgggaca tcctgccaga caccagcctt gggggcccat     2400

ccttcttcaa aatcatcacg gccaaggctg tcctgaagct gcaggccgga aacgccgagg     2460

aagccgccct gtggagggat ctggtccgca aagtcctggc atcctacttg gagacagccg     2520

aggaggcggt gaccctgggc gggagcctgg atgaaaactg tcaggaggtg ctgaaatttg     2580

ccacccggga gaatggcttc ctgctgcagt acctggtggc tatccccatg gagaaaggcc     2640

ttgactccca aggctgcttc tgcgcaggct gctcccggca gatcggcttc tcctttgtac     2700

gacccaagct ctgtgccttc tctggcctct attactgtga catctgccac caagacgatg     2760

cctcagtgat tccggccagg atcatccaca actgggacct caccaagcgc ccgatctgca     2820

ggcaggccct gaagtttctg acacagatcc gggcccagcc cctcatcaac ctgcagatgg     2880

tgaacgcgtc tctgtacgag catgtggagc ggatgcacct cattgggagg agacgggagc     2940

agctgaagct cctgggggat tacctgggcc tgtgccggag tggcgccctg aaggagctca     3000

gcaagaggct caaccacagg aattatctct tggaatctcc gcataggttc agtgttgctg     3060

acctccaaca gatcgcagac ggggtgtatg aaggattcct caaggccctg attgaatttg     3120

cctcccagca tgtctaccac tgcgacctgt gcacccagcg cggcttcatc tgccagatct     3180

gccagcacca cgacatcatc ttcccctttg agtttgacac cacagtcagg tgtgccgagt     3240

gcaagaccgt cttccaccag agctgccagg ctgtggtgaa gaagggctgc ccccgctgtg     3300

cccgccggcg caagtaccag gaacagaaca ttttcgcctg atgcccatct gctgaccccg     3360

ctctgaaagc cgggggtgag tgtggctcag ccatcccggc tgggtttgcc atcagcccag     3420

gatactcacc gtgtcacagc tgtgtcccct tgtcaggaag accctcagat gtggccagag     3480

caccggcctc ccagagaaag cccaggaagt ccccgtggtg tcccctggcc ctccccccac     3540

ccctctgctg caggaggcgt ggccaccacc agatgctccc tgtctggggc aggcagggcc     3600

gtttactcac taggccctgg ctcaccagcg tcccggcgcc tccgttaggg ctgcccaaac     3660

actgtggaaa ggggacttgg ggagcatttt caattccaca ttcctgatta aaaggtctag     3720

ttttttaagg tgggtttttc ccattcatat ttcaacagaa agtatttttt tattcttgac     3780

cctacgtgag tcacccatga aatccagaca ttctcacccc cagcggatgc acaggagcca     3840

ctcaggcctg gcttagaggt agcgggtggc tggtgggcag gccactgctg ggacagggtc     3900

tatgggccca cccagtgcct ttccttggcc ctcactgcca gtgccaaacc gcccctcagc     3960

agggcagggc cagtcctggc gaccccggtt cctctgtgtc ctctttactc cccaccccag     4020

tgcgtctcgc ctgctgagcc caccgctttc tcagcgtcag agcccctagc tcttctctag     4080

cctggggcct tggccccatt aggagaagga gaaatgactg gaaaccagca ctgtcagcac     4140

tttgagccct cctcggttta tggagggtcg ccgtcttgcc cacccccgat ccccgtgcgc     4200

tcctcacccc tctacagaca ggggcgctgc tgcagatgct ccaggcccac cttggtgggt     4260

gcccggggtc acactctctg cctgactgac ccctgccagg gcacagatag gcaggacccc     4320

agagagggca ggcagccacg ccctgcactg tggagaagtg acctggtcct aagctgtgca     4380

gggcgtgcgg gggaactgcc ctgtggatgc agccaccacc tcacaaagcc atgaattccc     4440

aaagcatcac tgaacttgcc cagccgggac actggagact gaagaagttc cccggagcag     4500

gactgccttt gaaggggcct tggggctggg gtgggagtct ggaattgttt tcaaagtgat     4560

ggtcagaccc tccaggcttc ggggaaatgt gggtttgctg gtctctctgt cgccttcccc     4620

cacctctcct ggacctagca ggccctcagt cctagctgtc ttacctgcac tcagcttgga     4680

gtcaggcctc aggtggagag ccgcatgtca ctgtcagaga tgagcccacc cccacccttc     4740

cctgggggcg attagctgct gagtcaccca cccagccttg gagctggatg cctgtgcagc     4800

agaacagagg caacggtggc aggcaggtgg aggctgcgca cagcttctcc cggtcatggc     4860

acacacctgt gcccagacgc caatgcctcc taagccagga gctgggttat gcaccgccat     4920

ggcccacatt aacgctccac cacaagccca gcctagtcag agccctcatt gccccatccc     4980

tgagtgggca ggagcctggc ctggggaggg cttcggcctg tgaggattct ccccgaaggt     5040

gccctcggag gcagcaggtt tgaggccctg gggggcccgt tccccagaag ctgccagtgc     5100

tttcagatgc attgactctt cccacctccc ctccctcaga aaggtagtgc ccacactatt     5160

tttaaaatgt tattttatgc aatacactgt tcctagtgag cagggctctg gccctgagga     5220

gtctttgcaa tgtattgaag gaattgctgc cgtgtgagtt ttgaatgatt ttgcagtaaa     5280

gacctgatct ttctcatc                                                   5298


<210> 4493
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4493
attactactg aaggaagaac gtgagtaggc cagatcagaa aagggagctc aggtaccttc       60

cagagagtga gacccagcgc ccttgtctcg cacccagtag gctttcatcc ccgccatggc      120

ggagctgatc cagaagaagc tacagggaga agtggagaaa tatcaacagc tacagaagga      180

cttaagtaaa tccatgtcgg ggaggcagaa acttgaagca caactaacag aaaataatat      240

cgtgaaagag gaactggccc tgctggatgg gtccaacgtg gtctttaaac ttctgggtcc      300

ggtgctagtc aaacaggagc tgggggaggc tcgggccaca gtagggaaga ggctggacta      360

tatcacagct gaaattaagc gatacgaatc ccagcttcgg gatcttgagc ggcagtcaga      420

gcaacagagg gagacccttg ctcagctgca gcaggagttc cagcgggccc aggcagcaaa      480

ggcaggggct cctggcaagg cctgacccca tggtgggggg aggggagggg aggggaggga      540

atgaggcagc tctaggatct atactgtagc taataaaatg t                          581


<210> 4494
<211> 348
<212> DNA
<213> Homo sapiens

<400> 4494
atgacaaaga aaagaaggaa caatggtcgt gccaaaaagg gccgcggcca cgtgcagcct       60

attcgctgca ctaactgtgc ccgatgcgtg cccaaggaca aggccattaa gaaattcgtc      120

attcgaaaca tagtggaggc cgcagcagtc agggacattt ctgaagtgag cgtcttcgat      180

gcctatgtgc ttcccaaact gtatgtgaag ctacattact gtgtgagttg tgcaattcac      240

agcaaagtag tcaggaatcg atctcgtgaa gcccgcaagg accgaacacc cccaccccga      300

tttagacctg cgggtgctgc cccaggtccc ccaccaaagc ccatgtaa                   348


<210> 4495
<211> 2190
<212> DNA
<213> Homo sapiens

<400> 4495
gttttcaaac cggagctgtg ggcgcggcgc tgctctgccg ttgggtgagg cgcggagcga       60

agtgaagggt ggcccaggtg gggccaggct gactgaatgt atctcctagc tatggactaa      120

ataatacatg gggggaaata aacaagtatt catgagggtg aaaatgtgac ccagcaggaa      180

aattacaact attttcaatt gacgttgaat agggagagcc aaaggaaatc aacatttgaa      240

ttgactaccc aatgtcctgc ccctgtttct gtcctgtagc acttaggaaa gatggatact      300

atgatgctga atgtgcggaa tctgtttgag cagcttgtgc gccgggtgga gattctcagt      360

gaaggaaatg aagtccaatt tatccagttg gcgaaggact ttgaggattt ccgtaaaaag      420

tggcagagga ctgaccatga gctggggaaa tacaaggatc ttttgatgaa agcagagact      480

gagcgaagtg ctctggatgt taagctgaag catgcacgta atcaggtgga tgtagagatc      540

aaacggagac agagagctga ggctgactgc gaaaagctgg aacgacagat tcagctgatt      600

cgagagatgc tcatgtgtga cacatctggc agcattcaac taagcgagga gcaaaaatca      660

gctctggctt ttctcaacag aggccaacca tccagcagca atgctgggaa caaaagacta      720

tcaaccattg atgaatctgg ttccatttta tcagatatca gctttgacaa gactgatgaa      780

tcactggatt gggactcttc tttggtgaag actttcaaac tgaagaagag agaaaagagg      840

cgctctacta gccgacagtt tgttgatggt ccccctggac ctgtaaagaa aactcgttcc      900

attggctctg cagtagacca ggggaatgaa tccatagttg caaaaactac agtgactgtt      960

cccaatgatg gcgggcccat cgaagctgtg tccactattg agactgtgcc atattggacc     1020

aggagccgaa ggaaaacagg tactttacaa ccttggaaca gtgactccac cctgaacagc     1080

aggcagctgg agccaagaac tgagacagac agtgtgggca cgccacagag taatggaggg     1140

atgcgcctgc atgactttgt ttctaagacg gttattaaac ctgaatcctg tgttccatgt     1200

ggaaagcgga taaaatttgg caaattatct ctgaagtgtc gagactgtcg tgtggtctct     1260

catccagaat gtcgggaccg ctgtcccctt ccctgcattc ctaccctgat aggaacacct     1320

gtcaagattg gagagggaat gctggcagac tttgtgtccc agacttctcc aatgatcccc     1380

tccattgttg tgcattgtgt aaatgagatt gagcaaagag gtctgactga gacaggcctg     1440

tataggatct ctggctgtga ccgcacagta aaagagctga aagagaaatt cctcagagtg     1500

aaaactgtac ccctcctcag caaagtggat gatatccatg ctatctgtag ccttctaaaa     1560

gactttcttc gaaacctcaa agaacctctt ctgacctttc gccttaacag agcctttatg     1620

gaagcagcag aaatcacaga tgaagacaac agcatagctg ccatgtacca agctgttggt     1680

gaactgcccc aggccaacag ggacacatta gctttcctca tgattcactt gcagagagtg     1740

gctcagagtc cacatactaa aatggatgtt gccaatctgg ctaaagtctt tggccctaca     1800

atagtggccc atgctgtgcc caatccagac ccagtgacaa tgttacagga catcaagcgt     1860

caacccaagg tggttgagcg cctgctttcc ttgcctctgg agtattggag tcagttcatg     1920

atggtggagc aagagaacat tgacccccta catgtcattg aaaactcaaa tgccttttca     1980

acaccacaga caccagatat taaagtgagt ttactgggac ctgtgaccac tcctgaacat     2040

cagcttctca agactccttc atctagttcc ctgtcacaga gagtccgttc caccctcacc     2100

aagaacactc ctagatttgg gagcaaaagc aagtctgcca ctaacctagg acgacaaggc     2160

aacttttttg cttctccaat gctcaagtga                                      2190


<210> 4496
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4496
attactactg aaggaagaac gtgagtaggc cagatcagaa aagggagctc aggtaccttc       60

cagagagtga gacccagcgc ccttgtctcg cacccagtag gctttcatcc ccgccatggc      120

ggagctgatc cagaagaagc tacagggaga agtggagaaa tatcaacagc tacagaagga      180

cttaagtaaa tccatgtcgg ggaggcagaa acttgaagca caactaacag aaaataatat      240

cgtgaaagag gaactggccc tgctggatgg gtccaacgtg gtctttaaac ttctgggtcc      300

ggtgctagtc aaacaggagc tgggggaggc tcgggccaca gtagggaaga ggctggacta      360

tatcacagct gaaattaagc gatacgaatc ccagcttcgg gatcttgagc ggcagtcaga      420

gcaacagagg gagacccttg ctcagctgca gcaggagttc cagcgggccc aggcagcaaa      480

ggcaggggct cctggcaagg cctgacccca tggtgggggg aggggagggg aggggaggga      540

atgaggcagc tctaggatct atactgtagc taataaaatg t                          581


<210> 4497
<211> 5891
<212> DNA
<213> Homo sapiens

<400> 4497
gcggagtcgg gaatcaaaac aaagggcctg gggggggcgg ggggaaggcg gcggggccgg       60

aatgtgagcg gaggtggagc cggcggcaga gggtggaaga atgaaagaaa agaaagatga      120

aaggatgttg aatcactttg catggctgta tgatggaagg aaacggaact gagaactcct      180

gcagtagaac acgtggatgg cttcaacaag ataatgatgc taagccatgg ctttggaaat      240

tctctaattg cttttctcgt cctgagcaga cgctgccaca tagtccccaa acgaaagagt      300

acatggagaa caagaaagtt gctgtggaac taaaggatgt accatcaccc cttcatgctg      360

gctctaagct ttttccagca gtcccacttc ctgatattcg ttctcttcag cagcctaaaa      420

tacagctttc ttctgtcccc aaagtaagct gctgtgctca ttgccctaat gaaccctcca      480

cttcgccaat gcgttttggt ggtggtggtg gcggtagcgg aggtaccagt agcttgattc      540

acccgggcgc actgttagac tcgcaaagca ccaggacaat cacgtgtcag gtagggtcag      600

ggtttgcttt ccagtctgca tcttcactcc agaatgcctc agctaggaac aatttggcag      660

gcattgcaag tgactttccc agcatgtgtc tagagagtaa cctgtcttcc tgcaaacacc      720

tgccctgttg tggaaaactc cacttccagt catgtcatgg taatgtgcac aagctgcatc      780

agtttccgag tctgcagggc tgcacctccg ctggctattt cccctgttct gatttcacaa      840

gcggggctcc agggcatttg gaagagcaca tttcacagtc ggagctaacg cctcacttgt      900

gcaccaactc tttgcacctt aatgtggtac ctccggtttg tttaaagggc tcactttact      960

gcgaagactg tctaaacaag ccagcaagaa atagcataat cgatgcggct aaagtctggc     1020

caaatatacc acctccaaat actcaacctg cacctcttgc tgtccctctg tgtaatggct     1080

gtggaaccaa aggaacaggg aaggagacca cgttgttatt ggcgaccagt ctaggcaaag     1140

ctgcttcaaa atttgaagtt gcagtagctg gacaggtgct agaaaactta ccccccattg     1200

gagttttttg ggatattgaa aactgctccg ttccctctgg ccggtcagca actgctgttg     1260

tgcaaagaat ccgtgagaag ttttttaaag gccacagaga agcagaattc atctgtgtat     1320

gtgacatcag taaagaaaac aaggaagtta ttcaagagct gaataattgc caggtaaccg     1380

ttgcccacat caatgctact gcaaagaatg ccgctgatga taaactgcgg cagagtctcc     1440

gcagatttgc aaatacacac actgctccag ccacagtggt tcttgtgtca actgatgtca     1500

attttgcatt ggaacttagt gacctgagac acaggcatgg tttccacatt attttggtcc     1560

ataaaaacca ggcctcagaa gcactgctgc atcatgctaa cgagctgatc agatttgaag     1620

agttcatttc cgacttgccc cccaggttac cactaaaaat gccacagtgc cacactctgc     1680

tctatgttta taacctacca gcaaataagg atggcaagag cgtcagcaac aggctcagac     1740

gcctgtccga taattgtggt gggaaagtgc tgagtatcac aggctgcagt gcaattctcc     1800

gcttcataaa ccaagatagt gcagagcgcg ctcagaagcg aatggaaaac gaagatgtct     1860

ttggtaatag gatcattgtg tcatttactc caaaaaatag agaactctgt gaaacaaaga     1920

gttcaaatgc aattgctgat aaagtgaagt ctcccaaaaa acttaagaat ccaaaattgt     1980

gcctcatcaa agatgcaagt gaacaatctt ccagtgccaa agccacgcct ggaaaagggt     2040

cacaggcaaa ttctggatct gctacaaaaa atacaaatgt taaaagttta caggagctgt     2100

gccgcatgga gtcaaaaact ggtcatagaa acagtgagca ccagcaaggt cacctgaggc     2160

tggtcgtacc cactcacggt aactcaagtg ctgcagtgtc gacgccgaaa aactcggggg     2220

tggcagaacc cgtttacaaa accagtcaga aaaaggagaa cctcagtgcc cgaagtgtta     2280

ccagttctcc tgtagagaaa aaagataaag aggagactgt attccaagtg agttacccgt     2340

ctgcttttag caagttagtt gcatccaggc aagtcagtcc tctgctcgca tctcagtctt     2400

ggtcttctag gagtatgtct ccaaaccttt taaacagagc atccccgctt gctttcaaca     2460

ttgcaaattc gagcagcgaa gccgactgcc cagacccatt tgcaaatggt gctgatgtcc     2520

aagtcagcaa catagactac agattatccc ggaaggagct gcagcagctc ctgcaggaag     2580

catttgccag gcatggcaag gtgaagagtg ttgagctcag cccccataca gattatcaac     2640

tcaaggctgt tgtgcaaatg gaaaacttac aagatgcgat cggtgcagtg aatagcctcc     2700

acagatacaa aattggcagc aaaaagatcc tggtctcact tgccaccggg gctgccagca     2760

aatcactctc tttactgagt gcagaaacaa tgtctgttct tcaggatgcc cctgcctgtt     2820

gcctgcctct gtttaaattt acagatatct atgaaaaaaa gtttggacac aagttgaatg     2880

tgtcagatct atataaatta acagacacgg tcgcaatccg tgaacaagga aacggacggc     2940

tggtgtgtct cctacccagc agtcaggccc gccagagccc cttggggtct tcccagtcac     3000

acgacggctc ctccacgaat tgcagcccaa ttatatttga agagttagaa tatcacgagc     3060

ctgtctgcag acagcattgt tccaataagg atttcagcga acatgaattt gatccagact     3120

cttacaagat tccttttgtg attctttctt tgaagacatt tgcgccccag gttcacagtc     3180

ttctccagac ccacgagggc accgtgcctt tattgagctt tccagattgt tacattgcag     3240

agtttggcga tctagaagta gtgcaagaaa accaaggagg tgttccctta gaacacttca     3300

ttacctgtgt tccaggtgta aacattgcca ctgctcagaa tggcatcaaa gtggttaaat     3360

ggattcacaa caagcccccg cctcccaaca ctgacccttg gcttctgcgt tcgaagagtc     3420

ctgtaggtaa cccccagctg atccagttca gtagagaagt gattgacttg ctgaaaagcc     3480

agccatcttg tgtcataccc atcagtcatt tcatcccatc ctatcaccat cattttgcaa     3540

agcagtgccg agtgtcagac tacggatact ccaagctgat tgagttatta gaagcagtgc     3600

ctcatgtatt gcagattctt ggaatgggct ccaaacgtct gctgaccctt acccacaggg     3660

cccaggtgaa gcgctttact caggatttac taaaacttct caaatcccag gccagcaaac     3720

aggtcattgt gagagaattc tcacaggctt atcactggtg tttctcaaag gactgggatg     3780

tcactgaata tggtgtttgt gagttgattg acatcgtatc agagattcca gacacaacca     3840

tctgcttgtc ccaacaagat aatgaaatgg tgatttgtat ccccaaaaga gaacgcactc     3900

aggatgaaat agaaaggaca aaacagttct ccaaggatgt cgttgatttg ctgcgtcacc     3960

aaccccattt ccggatgccc tttaataaat ttatcccttc ttaccatcac cactttggcc     4020

ggcagtgcaa acttgcgtac tatgggttta ccaaactact tgaacttttt gaagccatac     4080

ctgatacttt acaagtattg gaatgtggag aagaaaagat ccttactctg acagaggtgg     4140

agcggttcaa agctctagct gcccagtttg ttaaactcct tcggtcccaa aaagataact     4200

gccttatgat gacagatctc cttacagaat atgctaaaac ttttggttat acatttcgtc     4260

tccaagacta tgatgtcagt tccatttcgg ctttaactca gaaactctgc catgtcgtga     4320

aggttgccga tatagaatct ggcagacaga ttcagctgat caaccgaaag tctctgcgat     4380

ctctcactgc ccagttgctg gtattgttga tgtcttggga aggaaccacc catctttctg     4440

ttgaggagct caagagacat tacgaaagta cccacaacac tccccttaac ccctgtgaat     4500

atggattcat gaccttgacc gaactgctga agagcctgcc atacttggtt gaggttttca     4560

ctaatgataa gatggaagaa tgtgtgaagc tcacaagtct gtatttgttt gcaaagaatg     4620

tgcggtcttt acttcatact taccactacc agcagatttt ccttcatgag ttttccatgg     4680

cctataccaa gtatgtcgga gaaactctgc agcccaagac ctacggccac agcagcgtgg     4740

aggagctctt gggagcaatt ccacaggtgg tctggataaa aggacatggt cataagagaa     4800

ttgtagtgtt aaaaaatgac atgaaaagtc gtttgagttc actcagtctc tcccctgcca     4860

atcatgaaaa ccagccctcg gagggcgagc gcatcctgga ggtgcccgaa tcgcacacag     4920

cctcggaact caagcttgga gctgacggca gtgggcccag tcacacagag caggagcttc     4980

tccgcctgac cgacgactcc cccgtcgacc tcctgtgtgc gcctgtcccc tcgtgcctgc     5040

cgtcccctca gctgagacca gaccccgtta tcctccaatc tgctgatctc attcagtttg     5100

aggagcgccc tcaagagcct tctgaaatta tgattttaaa ccaagaagaa aaaatggaga     5160

ttccaatacc aggaaagagc aaaactctga cctctgactc cagctcgtcc tgcatctcag     5220

cagctgtccc cgtgcctccc tgcccctcct cggaaacctc cgagtcactg ctcagcaagg     5280

accccgtgga aagcccggcc aaaaagcaac ccaaaaatag agtcaaattg gcagccaact     5340

tttccttagc acctataacc aagctttaac tcccatttgg aatatagaat taggatggga     5400

aaacactgtc tgattctgca cacaaaagtg ggtttcaaaa atacatcctt ttctgtgtca     5460

tgaaaacccc ccgaagccat tgacttcatc ttacctgtgt tctatcatgt ttttcttttc     5520

cattgaacac agctttgagc tgaagtcttt cttttcttct tcctttttct ttcttttttc     5580

aattatttga agaacttgtg gcatttgtta aagaatcctt aatatatttt accaaatttt     5640

tagtaactat tatgaaatac aatggtgttc caaaagaaga aagcactaaa aactcaacta     5700

gcaggaagcg gttttgcttc cattgagcca cgtcggtggt gtcatcctac atgtagcata     5760

atagagtctc tcagcctttg cttactggtg tttccgacag tattaaccca gtgcgtggca     5820

tgtctttgaa gcaaagcctg tcccgctagc ctgtgtgttc acacaccaaa ggagaagggt     5880

aggcgagggg t                                                          5891


<210> 4498
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4498
attactactg aaggaagaac gtgagtaggc cagatcagaa aagggagctc aggtaccttc       60

cagagagtga gacccagcgc ccttgtctcg cacccagtag gctttcatcc ccgccatggc      120

ggagctgatc cagaagaagc tacagggaga agtggagaaa tatcaacagc tacagaagga      180

cttaagtaaa tccatgtcgg ggaggcagaa acttgaagca caactaacag aaaataatat      240

cgtgaaagag gaactggccc tgctggatgg gtccaacgtg gtctttaaac ttctgggtcc      300

ggtgctagtc aaacaggagc tgggggaggc tcgggccaca gtagggaaga ggctggacta      360

tatcacagct gaaattaagc gatacgaatc ccagcttcgg gatcttgagc ggcagtcaga      420

gcaacagagg gagacccttg ctcagctgca gcaggagttc cagcgggccc aggcagcaaa      480

ggcaggggct cctggcaagg cctgacccca tggtgggggg aggggagggg aggggaggga      540

atgaggcagc tctaggatct atactgtagc taataaaatg t                          581


<210> 4499
<211> 744
<212> DNA
<213> Homo sapiens

<400> 4499
cgcagctcgg agcgccgggg aagagagagt ccgaaccgcg gctctgcccc gcggcctagc       60

gttgctgcct gctttctcca gccccttctc ggcgtctgga agtgcgatca gtgggtgacc      120

gcggctgcga gggactttgt catccgtcct ccaggatctg gggagaaaga gccccatccc      180

ttctctctct gccaccattt cggacacccc gcagggactc gttttgggat tcgcactgac      240

ttcaaggaag gacgcgaacc cttctctgac cccagctcgg gcggccacct gtctttgccg      300

cggtgaccct tctctcatga ccctgcggtg ccttgagccc tccgggaatg gcggggaagg      360

gacgcggagc cagtggggga ccgcggggtc ggcggaggag ccatccccgc aggcggcgcg      420

tctggcgaag gccctgcggg agctcggtca gacaggatgg tactggggaa gtatgactgt      480

taatgaagcc aaagagaaat taaaagaggc accagaagga actttcttga ttagagatag      540

ctcgcattca gactacctac taacaatatc tgttaaaaca tcagctggac caactaatct      600

tcgaatcgaa taccaagacg gaaaattcag attggactct atcatatgtg tcaaatccaa      660

gcttaaacaa tttgacagtg tggttcatct gatcgactac tatgttcaga tgtgcaagga      720

taagcggaca ggtccagaag cccc                                             744


<210> 4500
<211> 582
<212> DNA
<213> Homo sapiens

<400> 4500
tatattgcaa ggcccagtgt tataaataac ttaatggtgg tgctgatcat aaaaaccaca       60

aaaattcaaa gaaggaaaat aatgtttttt gacctcttca gccttttaaa aatcctattc      120

cttgcctagt cgtttgtaaa ccacacagag ctccacgggg gtcttagtac ctcttgggga      180

aatctcgtgc tagactaggt tagagtagaa catttgtgtc caggtttatc caactcccta      240

ggcaactatt ataatccaat tccttatgat tatggaaata gtattaatca ctccttgaaa      300

tctgctttta gcattgggaa ggcctcagag aagacctaac cctaaagaca ggtgtgctca      360

gtgatattgt atatgccgaa aacttctttg tttcaggcag tttggagcat gtgaacacct      420

tgagccttga tgagttccag tatgtggtat attatgcaga gcattcagag caaatactct      480

ctctccgagc gcttaatccg aacaattgct gccatccgtt ccttcccaca tgataatgta      540

gaggacctca tcagaggggg agcagatgtg aactgcactc at                         582


<210> 4501
<211> 3888
<212> DNA
<213> Homo sapiens

<400> 4501
ggggaacagc tgatccgtct gttgggagga cagatatctc aaggccagga tggaagaatc       60

accactaagc cgggcaccat cccgtggtgg agtcaacttt ctcaatgtag cccggaccta      120

catccccaac accaaggtgg aatgtcacta cacccttccc ccaggcacca tgcccagtgc      180

cagtgactgg attggcatct tcaaggtgga ggctgcctgt gttcgggatt accacacatt      240

tgtgtggtct tccgtgcctg aaagtacaac tgatggttcc cccattcaca ccagtgtcca      300

gttccaagcc agctacctgc ccaaaccagg agctcagctc taccagttcc gatatgtgaa      360

ccgccagggc caggtgtgtg ggcagagccc ccctttccag ttccgagagc caaggcccat      420

ggatgaactg gtgaccctgg aggaggctga tgggggctct gacatcctgc tggttgtccc      480

caaggcaact gtgttacaga accagctcga tgagagccag caagaacgga atgacctgat      540

gcagctgaag ctacagctgg agggacaggt gacagagctg aggagccgag tgcaggagct      600

cgagagggct ctggcaactg ccaggcagga gcacacggag ctgatggaac agtacaaggg      660

gatttcccgg tcccatgggg agatcacaga agagagggac atcctgagcc ggcaacaggg      720

agaccatgtg gcacgcatcc tggagctaga ggatgacatc cagaccatca gtgagaaagt      780

gctgacgaag gaagtggagc tggacaggct tagagacaca gtgaaggccc tgactcggga      840

acaagagaag ctccttgggc aactgaaaga agtacaagca gacaaggagc aaagtgaggc      900

tgagctccaa gtggcacaac aggagaacca tcacttaaat ttggacctga aggaggcgaa      960

gagctggcaa gaggagcaga gtgctcaggc tcagcgactg aaagacaagg tggcccagat     1020

gaaggacacc ctaggccagg cccagcagcg ggtggccgag ctggagccct tgaaggagca     1080

gcttcgaggg gcccaggagc ttgcagcctc aagccagcag aaagccaccc ttcttgggga     1140

ggagttggcc agtgcagcag cagccaggga ccgcaccata gccgaactac accgcagccg     1200

cctggaagtg gctgaagtta acggcaggct ggctgagctc ggtttgcact tgaaggaaga     1260

aaaatgccaa tggagcaagg agcgggcagg gctgctgcag agtgtggagg cagagaagga     1320

caagatcctg aagctgagtg cagagatact tcgattggag aaggcagttc aggaggagag     1380

gacccaaaac caagtgttca agactgagct ggcccgggag aaggattcta gcctggtaca     1440

gttgtcagaa agtaagcggg agctgacaga gctgcggtca gccctgcgtg tgctccagaa     1500

ggaaaaggag cagttacagg aggagaaaca ggaattgcta gagtacatga gaaagctaga     1560

ggcccgcctg gagaaggtgg cagatgagaa gtggaatgag gatgccacca cagaggatga     1620

ggaggccgct gtggggctga gctgcccggc agctctgaca gactcagagg acgagtcccc     1680

agaagacatg aggctcccac cctatggcct ttgtgagcgt ggagacccag gctcctctcc     1740

tgctgggcct cgagaggctt ctccccttgt tgtcatcagc cagccggctc ccatttctcc     1800

tcacctctct gggccagctg aggacagtag ctctgactcg gaggctgaag atgagaagtc     1860

agtcctgatg gcagctgtgc agagtggggg tgaggaggcc aacttactgc ttcctgaact     1920

gggcagtgcc ttctatgaca tggccaggtg agttcaacca gcaaggccag gagggaggtg     1980

ggaggaggtc agagggaaag ggcatctgtg tggacagtca ccaggccctg ctcccaaccc     2040

ctgcccttct tggcctcagc caagaaaagg agatacaggt atggttaaca aggaaaatga     2100

ctcactgctc caaatcccag atgccttcag gtaatcccta cccctatctt atcaatgcac     2160

tcagaggtcc tgcctttaac tggcttctat gttgttctag caccatcttc tgcagagccc     2220

aaattgccct gcttcccctc tctcctgcct ctaccccttc cccaaccacc aggtaggtac     2280

ctagggtcct ccggggagga agggaggtga ccatggcccc cagggatagg agcagagaga     2340

agactgggat ccagcatcca tctggctaca actgaaatgc tttccctctt ccctgacttc     2400

cctgggtaac ccttagggaa gggaacctat agaggtgggg gtttcaggta tcagattgtc     2460

cccttctgcc ttccctttta ttcccaggtt caagggggca ggcacaggga agagagattt     2520

gatcatctag tcccggtttt gcctggatgt gagatgggct cagggcaggg agggggtgat     2580

gctgtcatcc ttctcggctg gagcaggaag atgaaggacg atgtcagact cattttcagc     2640

ctcattaggc agcagacgga gatggaggga ggagagcagg aggctggggg atgggctctg     2700

cactgcagag accagcaggg actaaagaag agaggacatg gggaactgga aaaataagcc     2760

ttccaggatt gtggggagaa agacgctgtg ggagaggcca ggatgctgca ttaggcacag     2820

gataacctgg gaacccaggc acatgggtcc tgctctccga agtctgcaag tcaagaaggg     2880

aacagagcac gccgaccctc tccctttccc ctctgtctct cttagtggct ttacagtggg     2940

taccctgtca gaaaccagca ctgggggccc tgccaccccc acatggaagg agtgtcctat     3000

ctgtaaggag cgctttcctg ctgagagtga caaggatgcc ctggaggacc acatggatgg     3060

acacttcttt ttcagcaccc aggacccctt cacctttgag tgatcttact ccctcgtaca     3120

tgcacaaata cacactcatg cacacacaca ctcacacaca tgcatacact taggtttcat     3180

gcccattttc tatcacactg ggctccatga tattctgttc cctaagaact gcttctgtgt     3240

gccctgtttt catcccaaga tttctcactt catcctctcc tacctggctc ttttgtccca     3300

gggaggggtc ctgttcggaa gcagtggctg aatttatccc ctgaaagtgg ttttggagga     3360

accgggatgg aggaggcctt cccctgtggg aatagaatcg tccactccta gccctggttg     3420

cttctgatac acagccactg cacacacaca ctcacactca cactcccttg tctgatgccc     3480

caaagccaat tcctggggca ccctaccctc tcttatttgg agtttccgtt ggtttacctg     3540

agttttctct ggggtctgca cagaggcagc agcatggaca tcatggcctc tcaggtccct     3600

tttggttctc agtttcattg gttcctcttt ctgttccccc attgacttct gtgccccacc     3660

ctagcctttt ccataacctt aggtattcag tttggagggg ttttttgtat ttttgaggat     3720

tcctgtattc tgtatcctct cctcgcatct cctcacatgg aaagaaataa tgtatttgtg     3780

ccttctgtga ggaatggggg gaacaagtgg tcccaggtat ccccatttcc aaggcccccc     3840

tccctctcca ggtcccccca cagcaataaa agcttccccc tgatatcc                  3888


<210> 4502
<211> 2053
<212> DNA
<213> Homo sapiens

<400> 4502
gcggtgacca cgtgacctcc gctgagcttt cgccagtgcc tgcggccctc ggcggcctag       60

tacacacgca cctgagtgag tggcaccaga ggaccctctc catgtttagg gacctcctgg      120

gcctcaggag cgtggcgccc gcccctgggc ggactccccc catccgcggg cgcgaatggt      180

ccgggccgcg tccgcagtgc tgctggctgc tccctggttg ctgggtgcaa agtgctgggt      240

tctgggtttc tggattcgcg ggccgttcac acgtagcctg tgccggctcc tcgggtgagt      300

ccgtccgcgc gcggtgcccc gggacggcct aggctgccgg gggtccgggg ccccaggcat      360

tccgggctgc agattgacgg ggatcccgga tgcaccgcgc gcccccgcgc cctcaccgac      420

gggtccagac ctggtgggaa gaaggtgcgg ggacgggtcc ctgaggatcc cgatgcctac      480

gagccaagat gctcagcttt ataggtgtga cctacacatg tgacttcacc tcagttttgt      540

gatccgtaaa atggacaaat tcgaagctac ttcacagtgc tgttgagagg attaaatgaa      600

acaatgcttg taaagctctt tgcaggaggg agcctcggaa gcagggcctg gccggcagag      660

cacacctgct gtcaccaggg accacaggca gcatgaagac ccccgtggag ctggccgtca      720

gtgggatgca gaccctcggc cttcagcacc gctgccgagg tggctaccgg gtcaaggcca      780

ggacgtcata tgtggatgag actctgtttg gcagcccagc aggcacccgg cctaccccac      840

cggacttcga tccgccctgg gtggagaagg ctaacagaac cagaggcgtg ggcaaggagg      900

catcgaaggc cttgggggca aaggggagct gtgagaccac cccctcaagg ggcagcaccc      960

ccaccctcac accaaggaag aagaacaaat acagacccat cagccacacc ccgtcttact     1020

gtgatgagtc gctgtttggc tcccgatctg aaggcgccag cttcggggcc ccgcggatgg     1080

cgaaggggga tgccgcaaag ctccgtgctc tcttgtggac gccaccacct acccccaggg     1140

gtagccactc gccccgcccc agggaggcac cactgcgagc cattcaccca gctggtccct     1200

ccaagacaga gccggggcca gcggcagact cccagaagtt atctatgggt gggttacact     1260

cttcacgccc cctgaagcgg ggactttccc attccctcac ccacctgaat gtccccagca     1320

ctggtcatcc agccaccagt gccccccaca caaatgggcc tcaggatctc aggccttcca     1380

cgtcaggggt gaccttccgg agccccctgg tgacttccag ggctcgctca gttagcattt     1440

cagtgccatc taccccacga cgaggtgggg ccacccagaa accaaagccc ccttggaaat     1500

gatactcttt catcagggtt gcctatgggg ccacggcgac aggtatggcc ccttgccagg     1560

gtaggaggac attcatcacc cagggaaccc caggtattaa agaagcccct gtgggggcag     1620

acagacatag caggggtggg cagtgcctcc ctttatcctg acaatctcta gtcgattctt     1680

gcctttttct cccgattgcg gatttggggg ccacctctaa gatgcctctc tccagccctg     1740

tctcaaccat actccaaatt agtgccaacc caggggcctg gcacctccca catcatccat     1800

tgtcttgctg ccaagtgcga ataaacggcg tgattgccaa cctggagggt cccctcttat     1860

cccttcaagc caagcttcct gctcaggatt agtttccagc taagtctgca agccctagag     1920

gagtttttcc aggctgtctg tgaagcctgg ggaacacaac ggcaactggg agatttgtga     1980

gtgaacactg tttcatctta atatgcttct gaatttattt tcatgtacta aatagatcag     2040

ctcatcaaag cca                                                        2053


<210> 4503
<211> 876
<212> DNA
<213> Homo sapiens

<400> 4503
cttgcgagtt tacccccacc tccccagcca ccagcctgtg ggtctcaaac caaggctact       60

tggtgctctg ctttgagttg cagaggtgac ttcatcaatg ctcctacccc gagttcttga      120

gacagacctg gaccgatccc ctaccttgga atctcctctc agcctttaag ctcacctggt      180

cagaatcctt ggatgagcct gtgggaccgt tcctcctagc ccggtggttt ggaaccagtg      240

gctttgggac tgtaagagga tggacaaaga ttctcagggg ctgctagatt catccctgat      300

ggcatcaggc actgccagcc gctcagagga tgaggagtca ctggcagggc agaagcgagc      360

ctcctcccag gccttgggca ccatccctaa acggagaagc tcctccaggt tcatcaagag      420

gaagaagttc gatgatgagc tggtggagag cagcctggca aaatcttcta cccgggcaaa      480

gggggccagt ggggtggaac cagggcgctg ttcggggagt gaaccctcct ccagtgagaa      540

gaagaaggta tccaaagccc ccagcactcc tgtgccaccc agcccagccc cagcccctgg      600

actcaccaag cgtgtgaaga agagtaaaca gccacttcag gtgaccaagg atctgggccg      660

ctggaagcct gcagatgacc tcctgctcat aaatgctgtg ttgcagacca acgacctgac      720

ctccgtccac ctgggcgtga aattcagctg ccgcttcacc cttcgggagg tccaggagcg      780

ttggtacgcc ctgctctacg atcctgtcat ctccaagttg gcctgtcagg ccatgaggca      840

gctgcaccca gaggctattg cagccatcca gagcaa                                876


<210> 4504
<211> 2841
<212> DNA
<213> Homo sapiens

<400> 4504
gagaccgcat cgtcggctcg gaggctgagg ggctgccgcg gccgggagcg cccctcgcct       60

cgctcctcgc tccgcttggt gtcatgtgat tctctgaggg agcagctgcg tgagtggaga      120

tgctttcagt ggtggagaat ggactggacc cccaggctgc catcccgaca catcatctca      180

gagttggagc acctgacgtt tgtcaacacg gatgtgggcc gctgccgggc atggctgcgg      240

ctggccctga acgatggcct gatggagtgc tacctgaagc tgctgctgca ggagcaggcc      300

cgcttgcaac tacagcggaa ggaatctctg gattccattt cgcattcttc aggctctgaa      360

gacatcgaag tccatcactc gggccataag atacggagga accagaagct gactgcctcc      420

tccctcagcc tggacacggc cagttcatcc cagctgtcct gcagcctaaa ctctgatagc      480

tgcttactcc aagagaatgg ctccaagagt ccagaccatt gtgaggagcc catgtcctgt      540

gactcagacc tgggcacagc aaatgctgag gactcagacc ggtctctgca agaaaaaaca      600

agagctggat ctcagaggat gacttctacc ggccttcccg ggagcaaccc ctggagagtg      660

cttcagacca cccaatagct tcttacaggg ggactccagg gtcaaggcct ggtctccaca      720

ggcatttttc tcaagaacca agaaaaaact gctccctggg ggcgttagac caagcgtgtg      780

taccttcccc aggaagaagg caagcccagg cagccccatc ccaggggcat aagagcttcc      840

gggtggtaca ccggagacag atgggactgt ccaacccatt ccggggtctc atgaagctgg      900

gcaccgtgga gcggcggggg gcaatgggca tctggaagga gctcttctgc gagctctccc      960

cgctggagtt ccgcctctac ctgagcaacg aggagcacac ctgtgtggag aactgctcgc     1020

tgcttcgctg tgagtctgtg gggccagccc atagtgatgg gcgctttgag ctggtcttct     1080

ctggcaagaa gctggccctg cgcgcctcct cccaggacga agctgaggac tggctggacc     1140

gggtgcggga ggccctgcag aaggtccggc ctcagcagga ggatgagtgg gtgaacgtgc     1200

agtacccaga ccagcctgag gaaccccccg aggcgcccca gggctgcctc tctccctcag     1260

acctgctctc ggagcccgcg gccctccagg gcacacagtt tgactggtcg tccgcccagg     1320

ttccagagcc agatgccatc aaggagtccc tgctgtactt gtacatggac aggacctgga     1380

tgccctatat attttctctg tccttggagg ctctgaaatg tttccgcatc aggaacaatg     1440

agaagatgct gagtgacagc cacggcgtgg agaccatccg ggacatcctg ccagacacca     1500

gccttggggg cccatccttc ttcaaaatca tcacggccaa ggctgtcctg aagctgcagg     1560

ccggaaacgc cgaggaagcc gccctgtgga gggatctggt ccgcaaagtc ctggcatcct     1620

acttggagac agccgaggag gcggtgaccc tgggcgggag cctggatgaa aactgtcagg     1680

aggtgctgaa atttgccacc cgggagaatg gcttcctgct gcagtacctg gtggctatcc     1740

ccatggagaa aggccttgac tcccaaggct gcttctgcgc aggctgctcc cggcagatcg     1800

gcttctcctt tgtacgaccc aagctctgtg ccttctctgg cctctattac tgtgacatct     1860

gccaccaaga cgatgcctca gtgattccgg ccaggatcat ccacaactgg gacctcacca     1920

agcgcccgat ctgcaggcag gccctgaagt ttctgacaca gatccgggcc cagcccctca     1980

tcaacctgca gatggtgaac gcgtctctgt acgagcatgt ggagcggatg cacctcattg     2040

ggaggagacg ggagcagctg aagctcctgg gggattacct gggcctgtgc cggagtggcg     2100

ccctgaagga gctcagcaag aggctcaacc acaggaatta tctcttggaa tctccgcata     2160

ggttcagtgt tgctgacctc caacagatcg cagacggggt gtatgaagga ttcctcaagg     2220

ccctgattga atttgcctcc cagcatgtct accactgcga cctgtgcacc cagcgcggct     2280

tcatctgcca gatctgccag caccacgaca tcatcttccc ctttgagttt gacaccacag     2340

tcaggtgtgc cgagtgcaag accgtcttcc accagagctg ccaggctgtg gtgaagaagg     2400

gctgcccccg ctgtgcccgc cggcgcaagt accaggaaca gaacattttc gcctgatgcc     2460

catctgctga ccccgctctg aaagccgggg gtgagtgtgg ctcagccatc ccggctgggt     2520

ttgccatcag cccaggatac tcaccgtgtc acagctgtgt ccccttgtca ggaagaccct     2580

cagatgtggc cagagcaccg gcctcccaga gaaagcccag gaagtccccg tggtgtcccc     2640

tggccctccc cccacccctc tgctgcagga ggcgtggcca ccaccagatg ctccctgtct     2700

ggggcaggca gggccgttta ctcactaggc cctggctcac cagcgtcccg gcgcctccgt     2760

tagggctgcc caaacactgt ggaaagggga cttggggagc attttcaatt ccacattcct     2820

gattaaaagg tctagttttt t                                               2841


<210> 4505
<211> 4076
<212> DNA
<213> Homo sapiens

<400> 4505
taaagagata gagtctcact atgttgccca gacaggattt gaattcctgg gctcaaggta       60

tgcttctgtc ttagctcctc agtagctgag accatgggca cccaccactg tgcccagatt      120

cgggctttct tgtaaaaagc ggatggatgc ttgaaactat tttctgaatc cctttggctc      180

ccaaatgtga atattctggg aaatattttt atccaaatta gctgagtaat cgagtagtta      240

ggcacatttt gaagactgag gcttgtcctt taaaagaagg gcagcccaca aactgacttc      300

cttgagccaa aaattgtttt aaaaggggaa gtacagccca aaacagtgat tttaaaatat      360

caacaaaaag agtcaaattc tgtaaaatat ttaaagagat ttattctgag ccaaatatga      420

gtgaccatgt cctgtgacac agccctcggg aaatcctgag aacatgtgcc caaggtggtc      480

agggtacagc ttggttttct acattttagg gagacatgag gcttcaatca aatacattta      540

agaaatacat tggttcagtc cagaaaggca ggacaacccg acgcgaggca gggagcttcc      600

aggttataga ggtcactgga gagcccggtg gggtgtaagt acactgcgct tataaaactc      660

tagcaggaag ctagcagctg tctccaaacc cagagaaggg gaaacaggaa tcgattagga      720

ataaaggatt ataatccact ttccttctga ggaaaagctg ggaaccttct cattttgcct      780

tatgaaaact aagctgaatc gactgctgcc aaacatctat taggcaaaat tggcctcttg      840

cccatgattt gactttccag cacagccagt tctttttctc ctctgcagct gattggctct      900

ggagtgtggc cagaagcctc tctcctgcaa ttaaaggagt cgggtctcta actgttgatc      960

tgtttttttc ccttctgagc aatggagctt accatcttta tcctgagact ggccatttac     1020

atcctgacat ttcccttgta cctgctgaac tttctgggct tgtggagctg gatatgcaaa     1080

aaatggttcc cctacttctt ggtgaggttc actgtgatat acaacgaaca gatggcaagc     1140

aagaagcggg agctcttcag taacctgcag gagtttgcgg gcccctccgg gaaactctcc     1200

ctgctggaag tgggctgtgg cacgggggcc aacttcaagt tctacccacc tgggtgcagg     1260

gtgacctgta ttgaccccaa ccccaacttt gagaagtttt tgatcaagag cattgcagag     1320

aaccgacacc tgcagtttga gcgctttgtg gtagctgccg gggagaacat gcaccaggtg     1380

gctgatggct ctgtggatgt ggtggtctgc accctggtgc tgtgctctgt gaagaaccag     1440

gagcggattc tccgcgaggt gtgcagagtg ctgagaccgg gaggggcttt ctatttcatg     1500

gagcatgtgg cagctgagtg ttcgacttgg aattacttct ggcaacaagt cctggatcct     1560

gcctggcacc ttctgtttga tgggtgcaac ctgaccagag agagctggaa ggccctggag     1620

cgggccagct tctctaagct gaagctgcag cacatccagg ccccactgtc ctgggagttg     1680

gtgcgccctc atatctatgg atatgctgtg aaatagtgtg agctggcagt taagagctga     1740

atggctcaaa gaatttaaag cttcagtttt acatttaaaa tgctaagtgg gagaagagaa     1800

accttttttt tggggggcgg tttttttggt ttgttgttgg tttttttttt ttttttggcg     1860

ggaagaaaga gttttgctct tgttgcccag gctggagtgc aatgacgtga tctccgctca     1920

ctgcaacctc cacctcgcgg gtttaagcga ttcttctgcc tcagcctccc tagtagctgg     1980

gattacaggt gcccaccacc atgcccagct aatttgtatt tttagttgag acagggtttc     2040

actacgttgg ccaggctggt cttgaactcc tgatctcagg caatccaccc acctcagcct     2100

cccaaagtgc tgggatgaca ggcgtgagca accgcaccca gcttaaggtt tttttgtttt     2160

gttttgagac ggagttttcg ctcttgttgc ccaggctgga gtgcaatgct gtgatctcag     2220

cttaccacaa cctccacctc ccgggttcaa gtgattcacc tgcctcagcc tcctgagtag     2280

ctggtattac aggcatgcgt caccacgccg gctaattttg tacttttagt agagatggtg     2340

tttccccacg ttggtcagtc tggtctcaaa ttcctgacct caggtgatct gcctgcctcg     2400

gcctcccaaa gtgctgtgat tacagacgtc agccaccatg cctggcctga aacctttttt     2460

aggtaaagtt gaattccatc cttaaaagtt tctgttatat cctatttagc cattttctat     2520

tgtctcccaa agaattcaca tcaaaaaaac agctttgaac tcccccttca aaggaaacag     2580

tcgactttca taattagcat ctaccattat ccccaaatct tattttattc attgacttga     2640

aattttttcc aattgctttt tttttttttt ttttaaggtt aagagcagag gtttactagg     2700

ccaaagaaag agaatagctc tctgttgcag agaggggtcc tggagaaatg ggttacccca     2760

gttgtcttat ttaaatggtt acccatcaga ttttaatttt atcttctctt tgagagcttg     2820

gtaataagaa gcacttaaat cactccaaag aagactttaa aaagggagca gtgaaaaggt     2880

cttaataatt tattgattga attaagaaat actagctaat taagaatctg agtctaaaca     2940

gcacagattt tttctttctg cttttaaatt gtgttttaaa aaaagagaca gggggctggg     3000

cgtggtggct cacgcctgta atcctagcac tttgggaggc cgaggcgggt ggatcacgag     3060

gtaggagtta aagaccagcc tggccaacat ggcaaaaccc tactaaagat acaaaaaaaa     3120

aaaaaaatta gccaggcgtg gtggtgggtg cctgtaatcc caggtacttg gaaggctgag     3180

gcaggagaat ctcttgaacc cagaaggcga aggttgcagt gaaccgagat catgccattg     3240

tactctagcc tgggtgacaa gagcaagact ccgtctcaaa aaaaaaaaaa aaaaaaaaaa     3300

gaagtagaga cagggagaca gggtctcact gtgttgccta ggccggtctt gaactcctgg     3360

gctcaagtga ttctcccacc ttgacctcct aaattgttgg gattacaggt gtgagacagt     3420

gcacctggcc gaaatagctc aagtttctga aaaacaaatc tgaatctatt tgttattctt     3480

agcgtcactg gtctggcttt cagaattaac atacaaggtt gccacaccta gttctgccca     3540

gctttatgtc ttttattcca gtattccacc aaagtttgtt ttcctgcatt ccagttctca     3600

agtcttaaga taaagattgt acttgacagt ttagtatatc cataaaacta tttgaggtgg     3660

ttaaggttct tgggttcatt ttccttaata ctttgctgaa tattgtagat tgtaggcaat     3720

gaaaaagtct actaaattag gaaaaccttg aataattagg tatcctaggt aagagcccct     3780

aaacatcaag caatctgtga gtctgtaaag aaataaatat tttttggatt attcttatct     3840

aattccaccc ctgttggaag atgatttctt tgttctttgc aactatggaa gctgtgaaaa     3900

tcatcacaag tgcctctgaa agcgagtgtt aggttggtta gagggtttaa tattttctgc     3960

aatggtttgt aggaatttta ataaatgtag tatattttct gagatgattt tgtaaaagta     4020

ctattttaaa tatcaaatca accaataaat tcacatttgt gttaggaaca gaaata         4076


<210> 4506
<211> 894
<212> DNA
<213> Homo sapiens

<400> 4506
acgcatgcgc aaaggcatgg agaccgtggg gtgagaatgg gcttgcgagt ttacccccac       60

ctccccagcc accagcctgt gggtctcaaa ccaaggctac ttggtgctct gctttgagtt      120

gcagaggtga cttcatcaat gctcctaccc cgagttcttg agacagacct ggaccgatcc      180

cctaccttgg gtgtgcactc ttgggagaac gaggggcgga gggtccgaat ctcctctcag      240

cctttaagct cacctggtca gaatccttgg atgagcctgt gggaccgttc ctcctagccc      300

ggtggtttgg aaccagtggc tttgggactg taagaggatg gacaaagatt ctcaggggct      360

gctagattca tccctgatgg catcaggcac tgccagccgc tcagaggatg aggagtcact      420

ggcagggcag aagcgagcct cctcccaggc cttgggcacc atccctaaac ggagaagctc      480

ctccaggttc atcaagagga agaagttcga tgatgagctg gtggagagca gcctggcaaa      540

atcttctacc cgggcaaagg gggccagtgg ggtggaacca gggcgctgtt cggggagtga      600

accctcctcc agtgagaaga agaaggtatc caaagccccc agcactcctg tgccacccag      660

cccagcccca gcccctggac tcaccaagcg tgtgaagaag agtaaacagc cacttcaggt      720

gaccaaggat ctgggccgct ggaagcctgc agatgacctc ctgctcataa atgctgtgtt      780

gcagaccaac gacctgacct ccgtccacct gggcgtgaaa ttcagctgcc gcttcaccct      840

tcgggaggtc caggagcgtt ggtacgccct gctctacgat cctgtcatct ccaa            894


<210> 4507
<211> 3118
<212> DNA
<213> Homo sapiens

<400> 4507
acacaattca ggcagtggag agaaggccgt ggggagtggc tgaggagtcc ctcaagagaa       60

gaggttgctg ttcactgatg gtggagtgtt ttgagagtgg tggaaccagg ttatcccttt      120

cttcttttaa cgtgtcatgt gattctctga gggagcagct gcgtgagtgg agatgctttc      180

agtggtggag aatggactgg acccccaggc tgccatcccg acacatcatc tcagagttgg      240

agcacctgac gtttgtcaac acggatgtgg gccgctgccg ggcatggctg cggctggccc      300

tgaacgatgg cctgatggag tgctacctga agctgctgct gcaggagcag gcccgcttgc      360

atgagtacta ccagcccacc gccctgctcc gagatgctga ggagggcgag ttcctcctta      420

gcttcctgca gggcctcacg tccttgtcct tcgaactctc ctacaagtct gccatcttaa      480

atgagtggac gctcacccca ctggccctgt ctgggctttg cccgctttct gagctggacc      540

ctctctctac ctctggtgca gaactacagc ggaaggaatc tctggattcc atttcgcatt      600

cttcaggctc tgaagacatc gaagtccatc actcgggcca taagatacgg aggaaccaga      660

agctgactgc ctcctccctc agcctggaca cggccagttc atcccagctg tcctgcagcc      720

taaactctga tagctgctta ctccaagaga atggctccaa gagtccagac cattgtgagg      780

agcccatgtc ctgtgactca gacctgggca cagcaaatgc tgaggactca gaccggtctc      840

tgcaagaggt attgttggaa ttcagcaaag cccaggtaaa ctctgtgcca accaacggac      900

tgagccaaga aacggagatc cccacaccac aggcctcgct ctccctccat ggcctcaaca      960

ccagcacata cctgcactgt gaggcacctg cagagcccct tcctgcccag gcagcctctg     1020

gaactcaaga tggtgtccac gtgcaggagc cgcgtcccca ggcgcccagc cccctggact     1080

tacagcagcc tgtagagagc acctcaggcc agcagccttc tagtactgtc agcgagacag     1140

ccagagaagt gggccaaggg aatggcctgc agaaggccca ggctcatgac ggagctggtc     1200

tgaagctggt agtttcctca cccaccagtc cgaaaaacaa gagctggatc tcagaggatg     1260

acttctaccg gccttcccgg gagcaacccc tggagagtgc ttcagaccac ccaatagctt     1320

cttacagggg gactccaggg tcaaggcctg gtctccacag gcatttttct caagaaccaa     1380

gaaaaaactg ctccctgggg gcgttagacc aagcgtgtgt accttcccca ggaagaaggc     1440

aagcccaggc agccccatcc caggggcata agagcttccg ggtggtacac cggagacaga     1500

tgggactgtc caacccattc cggggtctca tgaagctggg caccgtggag cggcgggggg     1560

caatgggcat ctggaaggag ctcttctgcg agctctcccc gctggagttc cgcctctacc     1620

tgagcaacga ggagcacacc tgtgtggaga actgctcgct gcttcgctgt gagtctgtgg     1680

ggccagccca tagtgatggg cgctttgagc tggtcttctc tggcaagaag ctggccctgc     1740

gcgcctcctc ccaggacgaa gctgaggact ggctggaccg ggtgcgggag gccctgcaga     1800

aggtccggcc tcagcaggag gatgagtggg tgaacgtgca gtacccagac cagcctgagg     1860

aaccccccga ggcgccccag ggctgcctct ctccctcaga cctgctctcg gagcccgcgg     1920

ccctccaggg cacacagttt gactggtcgt ccgcccaggt tccagagcca gatgccatca     1980

aggagtccct gctgtacttg tacatggaca ggacctggat gccctatata ttttctctgt     2040

ccttggaggc tctgaaatgt ttccgcatca ggaacaatga gaagatgctg agtgacagcc     2100

acggcgtgga gaccatccgg gacatcctgc cagacaccag ccttgggggc ccatccttct     2160

tcaaaatcat cacggccaag gctgtcctga agctgcaggc cggaaacgcc gaggaagccg     2220

ccctgtggag ggatctggtc cgcaaagtcc tggcatccta cttggagaca gccgaggagg     2280

cggtgaccct gggcgggagc ctggatgaaa actgtcagga ggtgctgaaa tttgccaccc     2340

gggagaatgg cttcctgctg cagtacctgg tggctatccc catggagaaa ggccttgact     2400

cccaaggctg cttctgcgca ggctgctccc ggcagatcgg cttctccttt gtacgaccca     2460

agctctgtgc cttctctggc ctctattact gtgacatctg ccaccaagac gatgcctcag     2520

tgattccggc caggatcatc cacaactggg acctcaccaa gcgcccgatc tgcaggcagg     2580

ccctgaagtt tctgacacag atccgggccc agcccctcat caacctgcag atggtgaacg     2640

cgtctctgta cgagcatgtg gagcggatgc acctcattgg gaggagacgg gagcagctga     2700

agctcctggg ggattacctg ggcctgtgcc ggagtggcgc cctgaaggag ctcagcaaga     2760

ggctcaacca caggaattat ctcttggaat ctccgcatag gttcagtgtt gctgacctcc     2820

aacagatcgc agacggggtg tatgaaggat tctccccgaa ggtgccctcg gaggcagcag     2880

gtttgaggcc ctggggggcc cgttccccag aagctgccag tgctttcaga tgcattgact     2940

cttcccacct cccctccctc agaaaggtag tgcccacact atttttaaaa tgttatttta     3000

tgcaatacac tgttcctagt gagcagggct ctggccctga ggagtctttg caatgtattg     3060

aaggaattgc tgccgtgtga gttttgaatg attttgcagt aaagacctga tctttctc       3118


<210> 4508
<211> 586
<212> DNA
<213> Homo sapiens

<400> 4508
agtgaagggt ggcccaggtg gggccaggct gactgaagtg agtagtgggg gtgccagacc       60

agatggatac tatgatgctg aatgtgcgga atctgtttga gcagcttgtg cgccgggtgg      120

agattctcag tgaaggaaat gaagtccaat ttatccagtt ggcgaaggac tttgaggatt      180

tccgtaaaaa gtggcagagg actgaccatg agctggggaa atacaaggat cttttgatga      240

aagcagagac tgagcgaagt gctctggatg ttaagctgaa gcatgcacgt aatcaggtgg      300

atgtagagat caaacggaga cagagagctg aggctgactg cgaaaagctg gaacgacaga      360

ttcagctgat tcgagagatg ctcatgtgtg acacatctgg cagcattcaa ctaagcgagg      420

agcaaaaatc agctctggct tttctcaaca gaggccaacc atccagcagc aatgctggga      480

acaaaagact atcaaccatt gatgaatctg gttccatttt atcagatatc agctttgaca      540

agactgatga atcactggat tgggactctt ctttggtgaa gacttt                     586


<210> 4509
<211> 4995
<212> DNA
<213> Homo sapiens

<400> 4509
agaccgcatc gtcggctcgg aggctgaggg gctgccgcgg ccgggagcgc ccctcgcctc       60

gctcctcgct ccgcttggtg tcatgtgatt ctctgaggga gcagctgcgt gagtggagat      120

gctttcagtg gtggagaatg gactggaccc ccaggctgcc atcccgacac atcatctcag      180

agttggagca cctgacgttt gtcaacacgg atgtgggccg ctgccgggca tggctgcggc      240

tggccctgaa cgatggcctg atggagtgct acctgaagct gctgctgcag gagcaggccc      300

gcttgcatga gtactaccag cccaccgccc tgctccgaga tgctgaggag ggcgagttcc      360

tccttagctt cctgcagggc ctcacgtcct tgtccttcga actctcctac aagtctgcca      420

tcttaaatga gtggacgctc accccactgg ccctgtctgg gctttgcccg ctttctgagc      480

tggaccctct ctctacctct ggtgcagaac tacagcggaa ggaatctctg gattccattt      540

cgcattcttc aggctctgaa gacatcgaag tccatcactc gggccataag atacggagga      600

accagaagct gactgcctcc tccctcagcc tggacacggc cagttcatcc cagctgtcct      660

gcagcctaaa ctctgatagc tgcttactcc aagagaatgg ctccaagagt ccagaccatt      720

gtgaggagcc catgtcctgt gactcagacc tgggcacagc aaatgctgag gactcagacc      780

ggtctctgca agaggtattg ttggaattca gcaaagccca ggtaaactct gtgccaacca      840

acggactgag ccaagaaacg gagatcccca caccacaggc ctcgctctcc ctccatggcc      900

tcaacaccag cacatacctg cactgtgagg cacctgcaga gccccttcct gcccaggcag      960

cctctggaac tcaagatggt gtccacgtgc aggagccgcg tccccaggcg cccagccccc     1020

tggacttaca gcagcctgta gagagcacct caggccagca gccttctagt actgtcagcg     1080

agacagccag agaagtgggc caagggaatg gcctgcagaa ggcccaggct catgacggag     1140

ctggtctgaa gctggtagtt tcctcaccca ccagtccgaa aaacaagagc tggatctcag     1200

aggatgactt ctaccggcct tcccgggagc aacccctgga gagtgcttca gaccacccaa     1260

tagcttctta cagggggact ccagggtcaa ggcctggtct ccacaggcat ttttctcaag     1320

aaccaagaaa aaactgctcc ctgggggcgt tagaccaagc gtgtgtacct tccccaggaa     1380

gaaggcaagc ccaggcagcc ccatcccagg ggcataagag cttccgggtg gtacaccgga     1440

gacagatggg actgtccaac ccattccggg gtctcatgaa gctgggcacc gtggagcggc     1500

ggggggcaat gggcatctgg aaggagctct tctgcgagct ctccccgctg gagttccgcc     1560

tctacctgag caacgaggag cacacctgtg tggagaactg ctcgctgctt cgctgtgagt     1620

ctgtggggcc agcccatagt gatgggcgct ttgagctggt cttctctggc aagaagctgg     1680

ccctgcgcgc ctcctcccag gacgaagctg aggactggct ggaccgggtg cgggaggccc     1740

tgcagaaggt ccggcctcag caggaggatg agtgggtgaa cgtgcagtac ccagaccagc     1800

ctgaggaacc ccccgaggcg ccccagggct gcctctctcc ctcagacctg ctctcggagc     1860

ccgcggccct ccagggcaca cagtttgact ggtcgtccgc ccaggttcca gagccagatg     1920

ccatcaagga gtccctgctg tacttgtaca tggacaggac ctggatgccc tatatatttt     1980

ctctgtcctt ggaggctctg aaatgtttcc gcatcaggaa caatgagaag atgctgagtg     2040

acagccacgg cgtggagacc atccgggaca tcctgccaga caccagcctt gggggcccat     2100

ccttcttcaa aatcatcacg gccaaggctg tcctgaagct gcaggccgga aacgccgagg     2160

aagccgccct gtggagggat ctggtccgca aagtcctggc atcctacttg gagacagccg     2220

aggaggcggt gaccctgggc gggagcctgg atgaaaactg tcaggaggtg ctgaaatttg     2280

ccacccggga gaatggcttc ctgctgcagt acctggtggc tatccccatg gagaaaggcc     2340

ttgactccca aggctgcttc tgcgcaggct gctcccggca gatcggcttc tcctttgtac     2400

gacccaagct ctgtgccttc tctggcctct attactgtga catctgccac caagacgatg     2460

cctcagtgat tccggccagg atcatccaca actgggacct caccaagcgc ccgatctgca     2520

ggcaggccct gaagtttctg acacagatcc gggcccagcc cctcatcaac ctgcagatgg     2580

tgaacgcgtc tctgtacgag catgtggagc ggatgcacct cattgggagg agacgggagc     2640

agctgaagct cctgggggat tacctgggcc tgtgccggag tggcgccctg aaggagctca     2700

gcaagaggct caaccacagg aattatctct tggaatctcc gcataggttc agtgttgctg     2760

acctccaaca gatcgcagac ggggtgtatg aaggattcct caaggccctg attgaatttg     2820

cctcccagca tgtctaccac tgcgacctgt gcacccagcg cggcttcatc tgccagatct     2880

gccagcacca cgacatcatc ttcccctttg agtttgacac cacagtcagg tgtgccgagt     2940

gcaagaccgt cttccaccag agctgccagg ctgtggtgaa gaagggctgc ccccgctgtg     3000

cccgccggcg caagtaccag gaacagaaca ttttcgcctg atgcccatct gctgaccccg     3060

ctctgaaagc cgggggtgag tgtggctcag ccatcccggc tgggtttgcc atcagcccag     3120

gatactcacc gtgtcacagc tgtgtcccct tgtcaggaag accctcagat gtggccagag     3180

caccggcctc ccagagaaag cccaggaagt ccccgtggtg tcccctggcc ctccccccac     3240

ccctctgctg caggaggcgt ggccaccacc agatgctccc tgtctggggc aggcagggcc     3300

gtttactcac taggccctgg ctcaccagcg tcccggcgcc tccgttaggg ctgcccaaac     3360

actgtggaaa ggggacttgg ggagcatttt caattccaca ttcctgatta aaaggtctag     3420

ttttttaagg tgggtttttc ccattcatat ttcaacagaa agtatttttt tattcttgac     3480

cctacgtgag tcacccatga aatccagaca ttctcacccc cagcggatgc acaggagcca     3540

ctcaggcctg gcttagaggt agcgggtggc tggtgggcag gccactgctg ggacagggtc     3600

tatgggccca cccagtgcct ttccttggcc ctcactgcca gtgccaaacc gcccctcagc     3660

agggcagggc cagtcctggc gaccccggtt cctctgtgtc ctctttactc cccaccccag     3720

tgcgtctcgc ctgctgagcc caccgctttc tcagcgtcag agcccctagc tcttctctag     3780

cctggggcct tggccccatt aggagaagga gaaatgactg gaaaccagca ctgtcagcac     3840

tttgagccct cctcggttta tggagggtcg ccgtcttgcc cacccccgat ccccgtgcgc     3900

tcctcacccc tctacagaca ggggcgctgc tgcagatgct ccaggcccac cttggtgggt     3960

gcccggggtc acactctctg cctgactgac ccctgccagg gcacagatag gcaggacccc     4020

agagagggca ggcagccacg ccctgcactg tggagaagtg acctggtcct aagctgtgca     4080

gggcgtgcgg gggaactgcc ctgtggatgc agccaccacc tcacaaagcc atgaattccc     4140

aaagcatcac tgaacttgcc cagccgggac actggagact gaagaagttc cccggagcag     4200

gactgccttt gaaggggcct tggggctggg gtgggagtct ggaattgttt tcaaagtgat     4260

ggtcagaccc tccaggcttc ggggaaatgt gggtttgctg gtctctctgt cgccttcccc     4320

cacctctcct ggacctagca ggccctcagt cctagctgtc ttacctgcac tcagcttgga     4380

gtcaggcctc aggtggagag ccgcatgtca ctgtcagaga tgagcccacc cccacccttc     4440

cctgggggcg attagctgct gagtcaccca cccagccttg gagctggatg cctgtgcagc     4500

agaacagagg caacggtggc aggcaggtgg aggctgcgca cagcttctcc cggtcatggc     4560

acacacctgt gcccagacgc caatgcctcc taagccagga gctgggttat gcaccgccat     4620

ggcccacatt aacgctccac cacaagccca gcctagtcag agccctcatt gccccatccc     4680

tgagtgggca ggagcctggc ctggggaggg cttcggcctg tgaggattct ccccgaaggt     4740

gccctcggag gcagcaggtt tgaggccctg gggggcccgt tccccagaag ctgccagtgc     4800

tttcagatgc attgactctt cccacctccc ctccctcaga aaggtagtgc ccacactatt     4860

tttaaaatgt tattttatgc aatacactgt tcctagtgag cagggctctg gccctgagga     4920

gtctttgcaa tgtattgaag gaattgctgc cgtgtgagtt ttgaatgatt ttgcagtaaa     4980

gacctgatct ttctc                                                      4995


<210> 4510
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 4510
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaatctgc ctaatcacct ggttatcccc acagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct ga                                              1522


<210> 4511
<211> 571
<212> DNA
<213> Homo sapiens

<400> 4511
cagcggtcac gtgacatggc cccggggagc cgaggtgagc gttccagctt ccggagccgg       60

agggggcccg gcgtacccag cccccagccc gacgtgacca tgctgtcccg cctcctaaaa      120

gaacaccagg ccaagcagaa tgaacgcaag gagctgcagg aaaagaggag gcgagaggct      180

atcactgcag cgacctgcct gacagaagct ttggtggatc acctcaatgt gggtgtggcc      240

caggcctaca tgaaccagag aaagctggac catgaggtga agaccctaca ggtccaggct      300

gcccaatttg ccaagcagac aggccagtgg atcggaatgg tggagaactt caaccaggca      360

ctcaaggaaa ttggggatgt ggagaactgg gctcggagca tcgagctgga catgcgcacc      420

attgccactg cactggaata tgtctacaaa gggcagctgc agtctgcccc ttcctagccc      480

ctgttccctc ccccaaccct atccctccta cctcacccgc agggggaagg agggaggctg      540

acaagccttg aataaaacac aagcctccgt t                                     571


<210> 4512
<211> 2038
<212> DNA
<213> Homo sapiens

<400> 4512
aaaaaaaaaa aagtaccaaa gccgaggcgc atcctcgcac ctgcctgcct tgggccagcg       60

ggcggggccc gggaacgtgc atttcaaagg ggccgcggtt cctgcgatgc gctggactct      120

gggaagcgcg aacagagcgt tttgcgggct ctgcggggag agctggcgcc ggcgtctccc      180

tgtagcagga ctgggcgccg cgcccgtggg tgggctgctg cccggccccg ccgcccagcc      240

aagccgccgc ctgggtggcc attcccaagc cggactccgg ggaagtggca gcgtggatcc      300

cagccgccag aattcgaggt ctgcggcggc tttcaaaact tgacaacttt cctttccagg      360

aggaccccgt tctggagcgt tatttcaaag gccacaaagc tgcgatcacc tccttggacc      420

tcagccccaa cggcaagcaa cttgctactg cttcttggga tacctttctc atgctatgga      480

atttcaagcc acatgctaga gcttacagat atgtgggtca caaggatgtt gtaaccagcg      540

tgcagttttc tccacatgga aacttattgg cgtctgcctc acgagacaga accgtgagac      600

tctggattcc tgataagaga ggaaaattct cagaatttaa agctcataca gctccagttc      660

gaagtgtaga cttttcagct gatggccagt ttctagctac agcttctgaa gacaaatcca      720

taaaagtatg gagcatgtat cgccagcgct tcctgtattc cttgtatcga catacacact      780

gggtacgctg tgccaaattt tcacccgatg gaagactaat tgtgtcatgt agtgaggata      840

aaactattaa aatttgggat accacaaata agcaatgtgt taataacttc tcagattccg      900

ttggatttgc aaattttgtg gactttaacc ctagtggtac atgcatagct tcagcaggtt      960

ctgatcaaac tgtgaaagtc tgggatgtaa gagtgaacaa attactacag cattaccaag     1020

ttcacagcgg tggagttaat tgcatatcat tccatccttc gggtaactat ctcatcacag     1080

cttcttcaga tggtaccctt aagattctgg acctcttaga aggaaggctc atctatacac     1140

ttcaaggaca tacgggacct gtctttactg tttcattttc aaaaggtgga gagctatttg     1200

catcaggagg tgcagacaca caggtcttat tatggaggac taactttgat gaattgcatt     1260

gtaaaggtct taccaaaaga aatctcaaaa gattacattt tgattcacca ccacatcttc     1320

ttgatatcta cccaagaaca ccacatcccc atgaggaaaa agttgagact gtagaaatta     1380

atccaaagct tgaggtaatc gatttgcaga tctctactcc ccctgttatg gatatccttt     1440

cttttgattc taccacaaca acagaaacca gtggtaggac tctgccagac aagggtgaag     1500

aggcctgtgg atatttcttg aacccttcct taatgtcacc agaatgtttg ccaacaacca     1560

cgaaaaagaa aacagaagac atgagtgacc tcccctgtga aagtcaaagg agcatacctc     1620

tcgctgtgac tgatgcttta gagcatatta tggaacaact caatgttttg acacagactg     1680

tttcaatctt ggagcagcga ctgactttga cagaggataa gctgaaagac tgccttgaaa     1740

atcagcaaaa gcttttcagt gctgtccaac agaaaagctg aataaaaaat tcattttcat     1800

ttgttgggca gaggcccaat aaatgaacaa atgtacatac actcaggaag gtagtacaag     1860

atactccata caacacaacc atgtgctatt tatcatggca tttcttaaaa gggtgagcaa     1920

cagaacaaaa ggcagaaaag gcatacctaa ggactaattt aaacacatat caatgtgaag     1980

gactaattta aattactatc atttatgatt gcagtaataa agtgataagc attcaagc       2038


<210> 4513
<211> 2391
<212> DNA
<213> Homo sapiens

<400> 4513
gcggctctgc cccgcggcct agcgttgctg cctgctttct ccagcccctt ctcggcgtct       60

ggaagtgtct ggagtttctt ttttttattt cccctaaact gccattcaaa ttaataatcc      120

tcctaataac ctgatctccc gctcctcccc accggcctgc ctcccgccct cgctccttcc      180

tccctccctc cctctctcct tcccacctcc agggtcgcag ccggagggaa acccggcagc      240

agtccgagag tggaggtgtc ccagcccgta gggggcgtcg ccgcgcggtg ggggatgggg      300

tcgaggcaat gatcctcgag gcttttgtgt gccctctgcg cacggaactc cgaccgccgc      360

ctccgagcgc ggggctggtt gcatccccgg gcatctcgtt cccaaattaa acgttaacgg      420

gggaaacaag ggcagacgcc cctcctctcc cgggcccctc ccacctcccc ttttcccccc      480

acccccccgc cccatgtccg ctgaggaggc tgcctggtgc ggaggcggcg gcggcggccg      540

cggccgaggt cgaggcgatc agtgggtgac cgcggctgcg agggactttg tcatccgtcc      600

tccaggatct ggggagaaag agccccatcc cttctctctc tgccaccatt tcggacaccc      660

cgcagggact cgttttggga ttcgcactga cttcaaggaa ggacgcgaac ccttctctga      720

ccccagctcg ggcggccacc tgtctttgcc gcggtgaccc ttctctcatg accctgcggt      780

gccttgagcc ctccgggaat ggcggggaag ggacgcggag ccagtggggg accgcggggt      840

cggcggagga gccatccccg caggcggcgc gtctggcgaa ggccctgcgg gagctcggtc      900

agacaggatg gtactgggga agtatgactg ttaatgaagc caaagagaaa ttaaaagagg      960

caccagaagg aactttcttg attagagata gctcgcattc agactaccta ctaacaatat     1020

ctgttaaaac atcagctgga ccaactaatc ttcgaatcga ataccaagac ggaaaattca     1080

gattggactc tatcatatgt gtcaaatcca agcttaaaca atttgacagt gtggttcatc     1140

tgatcgacta ctatgttcag atgtgcaagg ataagcggac aggtccagaa gccccccgga     1200

acggcactgt tcacctttat ctgaccaaac cgctctacac gtcagcacca tctctgcagc     1260

atctctgtag gctcaccatt aacaaatgta ccggtgccat ctggggactg cctttaccaa     1320

caagactaaa agattacttg gaagaatata aattccaggt ataaatgttt ctcttttttt     1380

aaacatgtct cacatagagt atctccgaat gcagctatgt aaaagagaac caaaacttga     1440

gtgctctgga taactatatg gaatgctttc taagaacagc tgaagctaat ctaatttaaa     1500

tttaacagct tgaagaggta gctaggtgtt taaagttcct ccagatactt ttacctgagt     1560

gatgcttccc ttcctaaggc tgaccaagac ctgttgatcc ttttagatta aaaataaaat     1620

gtcgcatgta aaggctgaag tcgcgtttta tcagaatgcc ttgccttctt aggttctttt     1680

ccattatgtc aaaggtccag gctccagtag gagagaaaga actcctcata ggaatactga     1740

agaagtggga aggaaccaag ctgacacagg cctcactgca atttgatatg cctgctgatc     1800

agagtctctt gggcatttta tattttgcat tctgatgtac ctaggagttt tgttaaacag     1860

atgatgtatg tgagtattta tcccatttta tgcaattaac caaatcaacc aaaaaaagtg     1920

accatgaagt cctgtatttg tctttttact acatgtagga actctcatgt gaatgagtac     1980

tgtagtaatc cattctatgg gagccttatt tcagaaatat ttcaaactgg tgcaaatgga     2040

aaagactttc tcttttcctt taaagctaaa gacaagaata tcatgctata caggtgcaac     2100

tcaatccccg ttaataaaaa ccaatgtagg tataggcatt ctaccctttg aaatagctgt     2160

gtcccaacct gttgccattg attttttgga aatggcttta gaaatatcca agttgtcctt     2220

gaattgtcta accatggaca taaacagttg tctcccttct actgtgtaga atactttgac     2280

ttaattttct tccagataca gggggatacc tgcctgtttt tcaaagtgtt tatttactgc     2340

tgttactatt tgattagaat gtattaaata aaaaaaacct gatttctaca a              2391


<210> 4514
<211> 2072
<212> DNA
<213> Homo sapiens

<400> 4514
acctgatcaa ggggaccgcc tccggtcccc ggccgtgggc accgggacga gcacggcgtc       60

cccacgccat cgatgtgtct tagagccgga gagtctggtt tccgaggacc cacagtcgct      120

cctgcacgcc caccccccgc aaaagtgcgg ccaggagggt cgcatcgagg gggcgccgcc      180

gggatgttta gaggaaccca cccccgtggc aggccaaggg ccaaggatcg ctatccttcc      240

ctgaacccgg gcgctcagct ggcccgggcg atcagtgggt gaccgcggct gcgagggact      300

ttgtcatccg tcctccagga tctggggaga aagagcccca tcccttctct ctctgccacc      360

atttcggaca ccccgcaggg actcgttttg ggattcgcac tgacttcaag gaaggacgcg      420

aacccttctc tgaccccagc tcgggcggcc acctgtcttt gccgcggtga cccttctctc      480

atgaccctgc ggtgccttga gccctccggg aatggcgggg aagggacgcg gagccagtgg      540

gggaccgcgg ggtcggcgga ggagccatcc ccgcaggcgg cgcgtctggc gaaggccctg      600

cgggagctcg gtcagacagg atggtactgg ggaagtatga ctgttaatga agccaaagag      660

aaattaaaag aggcaccaga aggaactttc ttgattagag atagctcgca ttcagactac      720

ctactaacaa tatctgttaa aacatcagct ggaccaacta atcttcgaat cgaataccaa      780

gacggaaaat tcagattgga ctctatcata tgtgtcaaat ccaagcttaa acaatttgac      840

agtgtggttc atctgatcga ctactatgtt cagatgtgca aggataagcg gacaggtcca      900

gaagcccccc ggaacggcac tgttcacctt tatctgacca aaccgctcta cacgtcagca      960

ccatctctgc agcatctctg taggctcacc attaacaaat gtaccggtgc catctgggga     1020

ctgcctttac caacaagact aaaagattac ttggaagaat ataaattcca ggtataaatg     1080

tttctctttt tttaaacatg tctcacatag agtatctccg aatgcagcta tgtaaaagag     1140

aaccaaaact tgagtgctct ggataactat atggaatgct ttctaagaac agctgaagct     1200

aatctaattt aaatttaaca gcttgaagag gtagctaggt gtttaaagtt cctccagata     1260

cttttacctg agtgatgctt cccttcctaa ggctgaccaa gacctgttga tccttttaga     1320

ttaaaaataa aatgtcgcat gtaaaggctg aagtcgcgtt ttatcagaat gccttgcctt     1380

cttaggttct tttccattat gtcaaaggtc caggctccag taggagagaa agaactcctc     1440

ataggaatac tgaagaagtg ggaaggaacc aagctgacac aggcctcact gcaatttgat     1500

atgcctgctg atcagagtct cttgggcatt ttatattttg cattctgatg tacctaggag     1560

ttttgttaaa cagatgatgt atgtgagtat ttatcccatt ttatgcaatt aaccaaatca     1620

accaaaaaaa gtgaccatga agtcctgtat ttgtcttttt actacatgta ggaactctca     1680

tgtgaatgag tactgtagta atccattcta tgggagcctt atttcagaaa tatttcaaac     1740

tggtgcaaat ggaaaagact ttctcttttc ctttaaagct aaagacaaga atatcatgct     1800

atacaggtgc aactcaatcc ccgttaataa aaaccaatgt aggtataggc attctaccct     1860

ttgaaatagc tgtgtcccaa cctgttgcca ttgatttttt ggaaatggct ttagaaatat     1920

ccaagttgtc cttgaattgt ctaaccatgg acataaacag ttgtctccct tctactgtgt     1980

agaatacttt gacttaattt tcttccagat acagggggat acctgcctgt ttttcaaagt     2040

gtttatttac tgctgttact atttgattag aa                                   2072


<210> 4515
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4515
gcatttgtgt cttttggact tctctgagcg ggtggaagaa tgaaagaaaa gaaagatgaa       60

aggatgttga atcactttgc atggctgtat gatggaagga aacggaactg agaactcctg      120

cagtagaaca cgtggatggc ttcaacaaga taatgatgct aagccatggc tttggaaatt      180

ctctaattgc ttttctcgtc ctgagcagac gctgccacat agtccccaaa cgaaagagta      240

catggagaac aagaaagttg ctgtggaact aaaggatgta ccatcacccc ttcatgctgg      300

ctctaagctt tttccagcag tcccacttcc tgatattcgt tctcttcagc agcctaaaat      360

acagctttct tctgtcccca aagtaagctg ctgtgctcat tgccctaatg aaccctccac      420

ttcgccaatg cgttttggtg gtggtggtgg cggtagcgga ggtaccagta gcttgattca      480

cccgggcgca ctgttagact cgcaaagcac caggacaatc acgtgtcagg tagggtcagg      540

gtttgctttc cagtctgcat cttcactcca gaatgcctca g                          581


<210> 4516
<211> 1025
<212> DNA
<213> Homo sapiens

<400> 4516
aacgtgatgg cgtcaggggc cggggcgccg cttcctgttg tcagtggccg agagaccgca       60

tcgtcggctc ggaggctgag gggctgccgc ggccgggagc gcccctcgcc tcgctcctcg      120

ctccgcttgg tgtcatgtga ttctctgagg gagcagctgc gtgagtggag atgctttcag      180

tggtggagaa tggactggac ccccaggctg ccatcccggt catcaagaag aagctggtgg      240

gatccgtgaa ggccttgcag aagcagtacg tgtccctgga cacggtggtc actagtgaag      300

acggagatgc caacaccatg tgcagcgccc tggaggccgt atttatccat ggcctgcacg      360

ccaagcacat ccgagctgag gccggaggaa aaaggaagaa aagtgcccac cagaagcctc      420

tgccccagcc tgtcttctgg cccctcctga aagctgtcac ccacaaacac atcatctcag      480

agttggagca cctgacgttt gtcaacacgg atgtgggccg ctgccgggca tggctgcggc      540

tggccctgaa cgatggcctg atggagtgct acctgaagct gctgctgcag gagcaggccc      600

gcttgcaact acagcggaag gaatctctgg attccatttc gcattcttca ggctctgaag      660

acatcgaagt ccatcactcg ggccataaga tacggaggaa ccagaagctg actgcctcct      720

ccctcagcct ggacacggcc agttcatccc agctgtcctg cagcctaaac tctgatagct      780

gcttactcca agagaatggc tccaagagtc cagaccattg tgaggagccc atgtcctgtg      840

actcagacct gggcacagca aatgctgagg actcagaccg gtctctgcaa gatataaaga      900

ttttcagctg ggcgcagtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg      960

gcggatcaca aaggcaacag atcgagacct ttctggctaa cacggtgaaa ccccatctct     1020

actaa                                                                 1025


<210> 4517
<211> 3609
<212> DNA
<213> Homo sapiens

<400> 4517
ggcggggcct cctggtgagc gcgcgccggg gcggcctccg ggaagtggga gacgctgcgg       60

gtcctgggcc caggccttgg gatgggcggg aaggcctggc cgcgccgggc tgtgggcact      120

gcaggaggcc cctgtgcaga acagatctcg gcccctttcc aaacactcct gatgcctcat      180

ttgcctctcg cttcttttcg accaccattt tgggggctga ggcactcacg gggcctcccc      240

aggtttcact ccgtttctac acagtcggag ccccatggat ctcccatctc ccggaggaac      300

cgtgaagcca aacagaagcg cctgcgagag aagcaggcta ctctggaggc tgagatagca      360

ggggagagca agtcacctgc agaatccatt aaggcctgga ggcctaagga gttagtattg      420

tatgaaatcc ctacgaaacc cggtgaaaag aaagatgtct ctgggcccct gcctcctgca      480

tacagccccc gatatgttga ggctgcctgg tacccgtggt gggtacgaga gggcttcttc      540

aaaccagaat atcaggcccg gctgccccaa gctacagggg agaccttttc catgtgtatc      600

ccacctccca atgtcactgg ctccctgcac attggccacg cactcacggt ggccatacag      660

gatgccctcg tgcgctggca ccggatgcgt ggggatcaag tgctgtgggt ccctggttca      720

gatcatgcag gaattgctac acaagctgtg gtggagaaac aactgtggaa ggaacgggga      780

gtgaggagac atgagctgag ccgggaggcc ttccttaggg aggtgtggca gtggaaggag      840

gcgaaaggtg gagagatctg tgagcagctg cgagctctgg gtgcctccct ggactgggat      900

cgagagtgtt ttaccatgga tgttggctcc tcagtggctg tgactgaagc ttttgtgcgg      960

ctctacaagg cggggttgct gtaccggaac catcagcttg tcaactggtc atgtgcttta     1020

agatcagcca tctcggacat tgaggtggag aaccggcccc tgcctggcca cacacagctt     1080

cgactgcctg gctgccccac ccccgtgtct tttggcctcc tattttctgt tgccttcccc     1140

gtggatggag agcctgatgc agaggttgtg gtaggaacca caaggccaga gacgctgcct     1200

ggagatgtgg ctgtggccgt tcatccagac gactcgcgat acacacatct acacgggcga     1260

cagcttcgtc accccttgat ggggcagcct cttcccctca tcacagacta tgctgttcag     1320

ccacatgtgg gcacgggggc agtgaaggtg actccagctc acagtcctgc cgatgctgag     1380

atgggggccc gacatggctt gagccccttg aatgtcattg cggaggatgg gaccatgacc     1440

tccctctgcg gggactggtt gcagggtctt caccggtttg tggcccggga aaagataatg     1500

tctgtgctga gtgaacgggg cctattccgg ggcctccaga accaccccat ggtactgccc     1560

atctgcagcc gttctgggga tgtgatagaa tacctgctga agaaccagtg gtttgtccgc     1620

tgccaggaaa tgggggcccg agctgccaag gctgtggagt cgggggccct ggagctcagt     1680

ccctccttcc accagaagaa ctggcagcac tggttttccc atattgggga ctggtgtgtc     1740

tcccggcagc tgtggtgggg ccatcagatt ccagcctacc tggttgtaga ggaccatgcg     1800

cagggagaag aggactgttg ggtggttggg cggtcagagg ctgaggccag agaggtagca     1860

gcggaactga cagggaggcc aggggcagag ctgaccctgg agagggatcc tgatgtccta     1920

gacacatggt tttcttctgc cctgttcccc ttttctgccc tgggctggcc ccaagagacc     1980

ccagaccttg ctcgtttcta ccccctgtca cttttggaaa cgggcagcga ccttctgctg     2040

ttctgggtgg gccgcatggt catgttgggg acccagctca cagggcagct gcccttcagc     2100

aaggtgcttc ttcatcccat ggttcgggac aggcagggcc ggaagatgag caagtccctg     2160

gggaatgtgc tggacccaag agacatcatc agtggggtgg agatgcagtt gctgcaggaa     2220

aagctgagaa gcggaaattt ggaccctgca gagctggcca ttgtggctgc agcacagaaa     2280

aaggactttc ctcacgggat ccctgagtgt gggacagatg ccctgagatt cacactctgc     2340

tcccatggag ttcaggcggg cgacttgcac ctgtcagtct ctgaggtcca gagctgccga     2400

catttctgca acaagatctg gaatgctctt cgctttatcc tcaatgcttt aggggagaaa     2460

tttgtgccac agcctgctga ggagctgtct ccctcctccc cgatggatgc ctggatcctg     2520

agccgccttg ccctggctgc ccaggagtgt gagcggggct tcctcacccg agagctctcg     2580

ctcgtcactc atgccctgca ccacttctgg cttcacaacc tctgtgacgt ctacctggag     2640

gctgtgaagc ccgtgctgtg gcactcgccc cgccccctgg ggccccctca ggtcctgttc     2700

tcctgcgctg acctcggcct ccgcctcctg gccccactga tgcccttcct ggctgaagag     2760

ctctggcaga ggctgccccc caggcctggt tgcccccctg cccccagcat ctcggttgcc     2820

ccctacccta gcgcctgcag cttggagcac tggcgccagc cagagctgga gcggcgcttc     2880

tcccgggtcc aagaggtcgt gcaggtgcta agggctctcc gagccacgta ccagctcacc     2940

aaagcccggc cccgagtgct gctgcagagc tcagagcctg gggaccaggg cctcttcgag     3000

gccttcttgg agcccctggg caccctgggc tactgtgggg ctgtgggcct gttaccccca     3060

ggcacagcag ctccctccgg ctgggcccag gctccactca gtgacacggc tcaagtctac     3120

atggagctgc agggcctggt ggacccgcag atccagctac ctctgttagc cgcccgaagg     3180

tacaagttgc agaagcagct tgatagcctc acagccagga ccccatcaga aggggaggca     3240

gggactcaga ggcaacaaaa gctttcttcc ctccagctgg aattgtcaaa actggacaag     3300

gcagcctctc acctccggca gctgatggat gagcctccag ccccagggag cccggagctc     3360

taactcatca tccccatcag ttttcctccc tctcagacct gtctttgagg acaaacagat     3420

ttgtcagctg tcagggtgca gtgggacgtc agagactatg tggtccatcg ccttcattgt     3480

gtaaatgagg acacagactg gcttggtcgc agtgactgtg gtgtccttga gatgctcaca     3540

ttactgcccg gcctgcctcc cacctggaag tctgggaatg aggagattga gataaacttt     3600

tgaaatccc                                                             3609


<210> 4518
<211> 3757
<212> DNA
<213> Homo sapiens

<400> 4518
aggctgcgcc gcggggcggc gggacggaat gtgggcgctg cgggggcttt tctctcctac       60

ccgaactgtg ggaacaatgg actgaaaggg gaagatggat tgaggggccg agcggggaag      120

cgagctgcac cggggaatca tgacttctgc agccgagata aagaagccac cagtggcccc      180

caagcccaag tttgttgtgg caaataataa gccagcccca cctcctattg cacctaaacc      240

cgacattgtg atttctagtg ttccacagtc gacaaagaaa atgaaaccag caatagcccc      300

aaaaccaaaa gtcctgaaga cctcacctgt tcgagagatt gggcagtcgc catcaaggaa      360

aatcatgttg aacctggaag ggcataaaca ggaattagct gaaagcactg acaactttaa      420

ttgtaaatat gaaggcaatc agagcaatga ttatatttca ccaatgtgtt cctgcagttc      480

tgagtgtatc cataagctgg gccatagaga gaatttgtgt gtaaagcagc ttgttttaga      540

gcccctggaa atgaatgaaa atttagaaaa cagtaaaatt gatgagactt tgactataaa      600

aactaggagt aaatgtgatt tgtatggtga aaaagccaag aaccagggtg gggttgtttt      660

aaaggcaagc gttttagaag aggagctcaa agatgcctta atacaccaaa tgccaccttt      720

tatttctgca cagaagcaca ggcccacaga cagcccagaa atgaatggtg gctgtaattc      780

aaatggacaa ttcagaattg aatttgcgga tttgtcacct tccccatcca gctttgaaaa      840

agttcctgat catcacagtt gccacttaca gcttcctagt gatgaatgtg aacattttga      900

aacttgccag gatgacagtg aaaaaagcaa taattgcttt cagtcatctg aactagaggc      960

tctggaaaat gggaaaagga gtactttaat atcttcagat ggagttagta agaaatcaga     1020

agtcaaagac cttggtccct tagaaattca tttagtacca tataccccaa aatttccaac     1080

tcccaagccc agaaagacac gaactgctcg tctgttacgc caaaagtgtg tagatactcc     1140

tagtgaaagc actgaagaac cggggaattc agacagtagc tcttcctgtc ttactgaaaa     1200

tagtttgaaa atcaataaaa tcagtgttct gcatcagaat gttttgtgta agcaggaaca     1260

ggtggataaa atgaagctag gaaataaaag tgaattgaat atggaatcca acagtgatgc     1320

acaggactta gtcaattcac agaaagccat gtgtaatgaa acaacttcct ttgaaaaaat     1380

ggcaccttct tttgataaag actctaattt gagttctgac agcacaactg tagatggttc     1440

tagtatgtcg cttgctgtgg acgaagggac cggttttata agatgtactg tatctatgag     1500

cctgcctaag cagctcaaat taacttgcaa tgaacatttg caatctggga gaaacctggg     1560

agtttctgcc cctcaaatgc aaaaggaatc tgttataaaa gaggaaaatt ctctacgaat     1620

tgtccccaaa aaacctcaaa gacatagctt gcctgctaca ggagtgctta aaaaggctgc     1680

ctccgaggag cttttggaaa aaagttctta tccttcaagt gaagaaaaaa gttcagagaa     1740

gagtctagaa agaaatcacc ttcagcattt gtgtgcccaa aaccgtggtg tgtcatcctc     1800

ctttgatatg cctaaacggg cttcagaaaa gccagtgtgg aagttacctc atcctatttt     1860

acccttttca gggaacccag aattcttaaa gtctgtcacc gtatcgtcaa acagtgagcc     1920

ttcaacagcc ctaaccaagc ccagagcaaa atcgttatct gctatggatg tggaaaagtg     1980

cactaagcct tgcaaagact ctacaaagaa aaactctttt aaaaagttgc tcagcatgaa     2040

actgtccatc tgtttcatga agagtgactt tcaaaaattt tggtccaaga gtagccaact     2100

cggagacacc accacaggcc acctctccag tggggagcag aaggggattg aaagtgattg     2160

gcaaggcttg ttggtaggag aggagaagag aagtaaaccc atcaaggcat attccacaga     2220

aaactatagc ctggaatctc aaaagaagag gaagaagtct cggggccaga ccagtgcagc     2280

taatggtctg agagctgagt ctttggatga ccaaatgctc tcccgggagt catcatctca     2340

ggcaccttac aagtctgtta caagcctctg tgcaccggag tatgaaaata tacgccatta     2400

tgaggaaata ccagagtacg agaacttgcc atttattatg gctatacgga aaactcaaga     2460

gttggaatgg cagaattcca gcagcatgga ggacgctgat gcaaatgtgt atgaggtaga     2520

agagccgtat gaagctccag atggccagct gcagcttgga cccagacatc agcattccag     2580

ttcaggagca tcccaggagg aacagaatga tcttggtctt ggtgaccttc cctctgatga     2640

ggaggaaatc atcaacagtt ctgatgaaga tgatgtcagc tctgagtcaa gtaaaggaga     2700

gcctgaccca ctggaagata aacaggatga agataatgga atgaaaagta aagttcatca     2760

tattgccaag gagatcatga gctcagagaa agtgtttgtg gatgtgttaa aacttttgca     2820

tattgatttc cgggatgcag tagctcatgc ttccaggcaa cttgggaaac cagtgattga     2880

ggaccggatt ctaaatcaga tcctatacta cttgcctcag ctgtatgagc tcaaccggga     2940

tctcttgaag gaactggagg aaagaatgtt gcactggact gaacaacaaa gaattgctga     3000

tatctttgta aagaagggac catatctaaa aatgtattcc acatacatca aagaatttga     3060

taagaatata gccttgctgg atgaacagtg caagaaaaat ccaggttttg ctgctgttgt     3120

tagagaattt gagatgagcc ctcgctgtgc taatctggcc ctcaagcact acctgctcaa     3180

gccggttcag aggatccccc agtacaggct gttgctgaca gattatttga agaatctcat     3240

agaagatgct ggagattaca gagacactca agatgccctt gctgttgtta tagaggtagc     3300

caaccacgcc aatgacacca tgaagcaagg agacaacttt cagaaactta tgcaaattca     3360

gtacagctta aatggacacc atgaaattgt gcagcctggt cgggtttttc tcaaagaagg     3420

aattctgatg aagctgtctc ggaaagtgat gcaacctcga atgtttttcc tgtttaatga     3480

tgccctgctg tatacaacac cagtgcagtc tgggatgtat aaactgaaca acatgctctc     3540

actggctgga atgaaggtca gaaaacctac ccaagaagcc tatcagaatg aattaaagat     3600

tgaaagtgta gaacgttcct tcattctctc agccagttct gccacagaaa gggatgaatg     3660

gctagaagcg atttccaggg caatagaaga gtatgccaag aaaagaatca ccttctgtcc     3720

tagtaggagt cttgatgagg cagactcaga aaataaa                              3757


<210> 4519
<211> 646
<212> DNA
<213> Homo sapiens

<400> 4519
ccgtggggtg agaatgggct tgcgagttta cccccacctc cccagccacc agcctgtggg       60

tctcaaacca aggctacttg gtgctctgct ttgagttgca gagaatctcc tctcagcctt      120

taagctcacc tggtcagaat ccttggatga gcctgtggga ccgttcctcc tagcccggtg      180

gtttggaacc agtggctttg ggactgtaag aggatggaca aagattctca ggggctgcta      240

gattcatccc tgatggcatc aggcactgcc agccgctcag aggatgagga gtcactggca      300

gggcagaagc gagcctcctc ccaggccttg ggcaccatcc ctaaacggag aagctcctcc      360

aggacccttt acaggttcat caagaggaag aagttcgatg atgagctggt ggagagcagc      420

ctggcaaaat cttctacccg ggcaaagggg gccagtgggg tggaaccagg gcgctgttcg      480

gggagtgaac cctcctccag tgagaagaag aaggtatcca aagcccccag cactcctgtg      540

ccacccagcc cagccccagc ccctggactc accaagcgtg tgaagaagag taaacagcca      600

cttcaggtga ccaaggatct gggccgctgg aagcctgcag atgacc                     646


<210> 4520
<211> 2041
<212> DNA
<213> Homo sapiens

<400> 4520
gcggtgacca cgtgacctcc gctgagcttt cgccagtgcc tgcggccctc ggcggcctag       60

tacacacgca cctgagtgag tggcaccaga ggaccctctc catgtttagg gacctcctgg      120

gcctcaggag cgtggcgccc gcccctgggc ggactccccc catccgcggg cgcgaatggt      180

ccgggccgcg tccgcagtgc tgctggctgc tccctggttg ctgggtgcaa agtgctgggt      240

tctgggtttc tggattcgcg ggccgttcac acgtagcctg tgccggctcc tcgggtgagt      300

ccgtccgcgc gcggtgcccc gggacggcct aggctgccgg gggtccgggg ccccaggcat      360

tccgggctgc agattgacgg ggatcccgga tgcaccgcgc gcccccgcgc cctcaccgac      420

gggtccagac ctggtgggaa gaaggtgcgg ggacgggtcc ctgaggatcc cgatgcctac      480

gagccaagat gctcaggtgt gacctacaca tgtgacttca cctcagtttt gtgatccgta      540

aaatggacaa attcgaagct acttcacagt gctgttgaga ggattaaatg aaacaatgct      600

tgtaaagctc tttgcaggag ggagcctcgg aagcagggcc tggccggcag agcacacctg      660

ctgtcaccag ggaccacagg cagcatgaag acccccgtgg agctggccgt cagtgggatg      720

cagaccctcg gccttcagca ccgctgccga ggtggctacc gggtcaaggc caggacgtca      780

tatgtggatg agactctgtt tggcagccca gcaggcaccc ggcctacccc accggacttc      840

gatccgccct gggtggagaa ggctaacaga accagaggcg tgggcaagga ggcatcgaag      900

gccttggggg caaaggggag ctgtgagacc accccctcaa ggggcagcac ccccaccctc      960

acaccaagga agaagaacaa atacagaccc atcagccaca ccccgtctta ctgtgatgag     1020

tcgctgtttg gctcccgatc tgaaggcgcc agcttcgggg ccccgcggat ggcgaagggg     1080

gatgccgcaa agctccgtgc tctcttgtgg acgccaccac ctacccccag gggtagccac     1140

tcgccccgcc ccagggaggc accactgcga gccattcacc cagctggtcc ctccaagaca     1200

gagccggggc cagcggcaga ctcccagaag ttatctatgg gtgggttaca ctcttcacgc     1260

cccctgaagc ggggactttc ccattccctc acccacctga atgtccccag cactggtcat     1320

ccagccacca gtgcccccca cacaaatggg cctcaggatc tcaggccttc cacgtcaggg     1380

gtgaccttcc ggagccccct ggtgacttcc agggctcgct cagttagcat ttcagtgcca     1440

tctaccccac gacgaggtgg ggccacccag aaaccaaagc ccccttggaa atgatactct     1500

ttcatcaggg ttgcctatgg ggccacggcg acaggtatgg ccccttgcca gggtaggagg     1560

acattcatca cccagggaac cccaggtatt aaagaagccc ctgtgggggc agacagacat     1620

agcaggggtg ggcagtgcct ccctttatcc tgacaatctc tagtcgattc ttgccttttt     1680

ctcccgattg cggatttggg ggccacctct aagatgcctc tctccagccc tgtctcaacc     1740

atactccaaa ttagtgccaa cccaggggcc tggcacctcc cacatcatcc attgtcttgc     1800

tgccaagtgc gaataaacgg cgtgattgcc aacctggagg gtcccctctt atcccttcaa     1860

gccaagcttc ctgctcagga ttagtttcca gctaagtctg caagccctag aggagttttt     1920

ccaggctgtc tgtgaagcct ggggaacaca acggcaactg ggagatttgt gagtgaacac     1980

tgtttcatct taatatgctt ctgaatttat tttcatgtac taaatagatc agctcatcaa     2040

a                                                                     2041


<210> 4521
<211> 580
<212> DNA
<213> Homo sapiens

<400> 4521
gagtcggcca ggaggggcgg ccgcggcagg tgcaggtgct ggcgccgtgc agggcgcggt       60

tatcttatga tgaggctttt gctatggcta atgatccctt ggaaggcttc catgaagtaa      120

accttgcttc acctacttct ccggaccttc ttggtgtgta tgaatcagga actcaagagc      180

agactacctc accaagtgtc atctaccggc cacacccttc agctttatcc tctgtaccta      240

tccaggcaaa tgcattagat gtttctgaac ttcctacaca acccgtgtat tcatccccca      300

gacgtttaaa ttgtgcggaa atatctagta tcagctttca tgttacagac ccagcccctt      360

gctctacctc tggagtcaca gctggattaa ctaaattaac tacaagaaag gacaactata      420

atgcagagag agagttttta cagggtgcta ctataacaga ggcttgcgat ggcagtgatg      480

atatttttgg gttgagtact gatagtctgt ctcgtttacg aagcccatct gttttggaag      540

ttagagaaaa gggctatgaa cgattaaaag aagaactcgc                            580


<210> 4522
<211> 570
<212> DNA
<213> Homo sapiens

<400> 4522
aagtgaaggg tggcccaggt ggggccaggc tgactgaagt gagtagtggg ggtgccagac       60

cagtgtatct cctagctatg gactaaataa tacatggggg gaaataaaca agtattcatg      120

agggtgaaaa tgtgacccag caggaaaatt acaactattt tcaattgacg ttgaatagga      180

aagatggata ctatgatgct gaatgtgcgg aatctgtttg agcagcttgt gcgccgggtg      240

gagattctca gtgaaggaaa tgaagtccaa tttatccagt tggcgaagga ctttgaggat      300

ttccgtaaaa agtggcagag gactgaccat gagctgggga aatacaagga tcttttgatg      360

aaagcagaga ctgagcgaag tgctctggat gttaagctga agcatgcacg taatcaggtg      420

gatgtagaga tcaaacggag acagagagct gaggctgact gcgaaaagct ggaacgacag      480

attcagctga ttcgagagat gctcatgtgt gacacatctg gcagcattca actaagcgag      540

gagcaaaaat cagctctggc ttttctcaac                                       570


<210> 4523
<211> 984
<212> DNA
<213> Homo sapiens

<400> 4523
gcggccgagg tcgaggtaag agcgcggcgt tggtggtttg cattttccgc agcgctcgcg       60

accgcccgct cggccccggc ctcgcctcgg agccccgcga gggctgcgcg ctcgggccga      120

ttcctcgaca gcgcccgcgg cggcgagaac caccgcagcc atcctggtcc gggagcgacc      180

gccgcggcac ccccaacccc gccagagcgg gcaccaggaa gcggggggag gggagcgagg      240

agcctcccgg gcggagatgc ggcagctccc gcacctccgc accccgggcg atcagtgggt      300

gaccgcggct gcgagggact ttgtcatccg tcctccagga tctggggaga aagagcccca      360

tcccttctct ctctgccacc atttcggaca ccccgcaggg actcgttttg ggattcgcac      420

tgacttcaag gaaggacgcg aacccttctc tgaccccagc tcgggcggcc acctgtcttt      480

gccgcggtga cccttctctc atgaccctgc ggtgccttga gccctccggg aatggcgggg      540

aagggacgcg gagccagtgg gggaccgcgg ggtcggcgga ggagccatcc ccgcaggcgg      600

cgcgtctggc gaaggccctg cgggagctcg gtcagacagg atggtactgg ggaagtatga      660

ctgttaatga agccaaagag aaattaaaag aggcaccaga aggaactttc ttgattagag      720

atagctcgca ttcagactac ctactaacaa tatctgttaa aacatcagct ggaccaacta      780

atcttcgaat cgaataccaa gacggaaaat tcagattgga ctctatcata tgtgtcaaat      840

ccaagcttaa acaatttgac agtgtggttc atctgatcga ctactatgtt cagatgtgca      900

aggataagcg gacaggtcca gaagcccccc ggaacggcac tgttcacctt tatctgacca      960

aaccgctcta cacgtcagca ccat                                             984


<210> 4524
<211> 1936
<212> DNA
<213> Homo sapiens

<400> 4524
tgcggctgct accgtcgccg cggagaaatt gttggatctg gcagtctagg aatgaggtga       60

cttcatcaat gctcctaccc cgagttcttg agacagacct ggaccgatcc cctaccttgg      120

gtgtgcactc ttgggagaac gaggggcgga gggtccgaat ctcctctcag cctttaagct      180

cacctggtca gaatccttgg atgagcctgt gggaccgttc ctcctagccc ggtggtttgg      240

aaccagtggc tttgggactg taagaggatg gacaaagatt ctcaggggct gctagattca      300

tccctgatgg catcaggcac tgccagccgc tcagaggatg aggagtcact ggcagggcag      360

aagcgagcct cctcccaggc cttgggcacc atccctaaac ggagaagctc ctccaggttc      420

atcaagagga agaagttcga tgatgagctg gtggagagca gcctggcaaa atcttctacc      480

cgggcaaagg gggccagtgg ggtggaacca gggcgctgtt cggggagtga accctcctcc      540

agtgagaaga agaaggtatc caaagccccc agcactcctg tgccacccag cccagcccca      600

gcccctggac tcaccaagcg tgtgaagaag agtaaacagc cacttcaggt gaccaaggat      660

ctgggccgct ggaagcctgc agatgacctc ctgctcataa atgctgtgtt gcagaccaac      720

gacctgacct ccgtccacct gggcgtgaaa ttcagctgcc gcttcaccct tcgggaggtc      780

caggagcgtt ggtacgccct gctctacgat cctgtcatct ccaagttggc ctgtcaggcc      840

atgaggcagc tgcacccaga ggctattgca gccatccaga gcaaggccct gtttagcaag      900

gctgaggagc agctgctgag caaagtggga tcgaccagcc agcccacctt ggagaccttc      960

caggacctgc tgcacagaca ccctgatgcc ttctacctgg cccgtaccgc gaaggccctg     1020

caggcccact ggcagctcat gaagcagtat tacctgctgg aggaccagac agtgcagccg     1080

ctgcccaaag gggaccaagt gctgaacttc tctgatgcag aggacctgat tgatgacagt     1140

aagctcaagg acatgcgaga tgaggtcctg gaacatgagc tgatggtggc tgaccggcgc     1200

cagaagcgag agattcggca gctggaacag gaactgcata agtggcaggt gctagtggac     1260

agcatcacag gcatgagctc tccggacttc gacaaccaga cactggcagt gctgcggggc     1320

cgcatggtgc ggtacctgat gcgctcgcgt gagatcaccc tgggcagagc aaccaaggat     1380

aaccagattg atgtggacct gtctctggag ggtccggcct ggaagatatc ccggaaacaa     1440

ggtgtcatca agctgaagaa caacggtgat ttcttcattg ccaatgaggg tcgacggccc     1500

atctacatcg atggacggcc ggtgctctgt ggctccaaat ggcgcctcag caacaactct     1560

gtggtggaga tcgccagcct gcgattcgtc ttccttatca accaggacct cattgccctc     1620

atcagggctg aggctgccaa gatcacacca cagtgaggag tggtggcagg actcgtgggc     1680

cctctccggc ctgtttcccc tgccactcca gcccccttga gctgggaact caggctcctg     1740

gaaaaacctg ggcagtggga ggctcagctg cgggccattg atttgagcct ttgagggagg     1800

atagggctgg cctttgtgaa gccagcagag gctgagaacc tcaggcttcc ctagatccag     1860

agcccctccc catcttcctc tctctaaaaa caaccctacc ccccattgcc accttcactc     1920

ctgtgtctcc agctga                                                     1936


<210> 4525
<211> 894
<212> DNA
<213> Homo sapiens

<400> 4525
gttagcccag agggaaagaa agaactgggg cgatccggta ggtaaaggag ggaaccccca       60

ttcattttct acctttgggg ctcctcttct gcatgaaggt ataaagggag attttccttg      120

tctctccctc aaaatgaaga acacatgtaa atccttgttt ttcctggtga ggcaggggag      180

gccatagcca caatgcttaa ctgcatgcat ctaacatggg gctggtttta accccagcgc      240

tctgacctaa actgctcagc tcccggaaat tccaagggac ctggtggcct tagtctttca      300

ggtggaacgg tgtgcgacat gggaaagaaa accaagcgga cagctgacag ttcttcttca      360

gaggatgagg aggagtatgt tgtggagaag gtgctagaca ggcgcgtggt taagggacaa      420

gtggaatatc tactgaagtg gaaaggcttt tctgaggagc acaatacttg ggaacctgag      480

aaaaacttgg attgccctga gctaatttct gaatttatga aaaagtataa gaagatgaag      540

gagggtgaaa ataataaacc cagggagaag tcagaaagta acaagaggaa atccaatttc      600

tcaaacagtg ccgatgacat caaatctaaa aaaaagagag agcagagcaa tgatatcgct      660

cggggctttg agagaggact ggaaccagaa aagatcattg gggcaacaga ttcctgtggt      720

gatttaatgt tcctaatgaa atggaaagac acagatgaag ctgacctggt tcttgcaaaa      780

gaagctaatg tgaaatgtcc acaaattgtg atagcatttt atgaagagag actgacatgg      840

catgcatatc ctgaggatgc ggaaaacaaa gagaaagaaa cagcaaagag ctaa            894


<210> 4526
<211> 1532
<212> DNA
<213> Homo sapiens

<400> 4526
gatagctgcc ggctccggct tccacttggt cggttgcgcg ggagactatg gcgtcctcct       60

cggtcccacc agccacggta tcggcggcga cagcaggccc cggcccaggt ttcggcttcg      120

cctccaagac caagaagaag catttcgtgc agcagaaggt gaaggtgttc cgggcggccg      180

acccgctggt gggtgtgttc ctgtggggcg tagcccactc gatcaatgag ctcagccagg      240

tgcctccccc ggtgatgctg ctgccagatg actttaaggc cagctccaag atcaaggagt      300

attgtcccca ggtcttcagg aacctccgtg atcgatttgg cattgatgac caagattact      360

tggtgtccct tacccgaaac ccccccagcg aaagtgaagg cagtgatggt cgcttcctta      420

tctcctacga tcggactctg gtcatcaaag aagtatccag tgaggacatt gctgacatgc      480

atagcaacct ctccaactat caccagtaca ttgtgaagtg ccatggcaac acgcttctgc      540

cccagttcct ggggatgtac cgagtcagtg tggacaacga agacagctac atgcttgtga      600

tgcgcaatat gtttagccac cgtcttcctg tgcacaggaa gtatgacctc aagggttccc      660

tagtgtcccg ggaagccagc gataaggaaa aggttaaaga attgcccacc cttaaggata      720

tggactttct caacaagaac cagaaagtat atattggtga agaggagaag aaaatatttc      780

tggagaagct gaagagagat gtggagtttc tagtgcagct gaagatcatg gactacagcc      840

ttctgctagg catccacgac atcattcggg gctctgaacc agaggaggaa gcgcccgtgc      900

gggaggatga gtcagaggtg gatggggact gcagcctgac tggacctcct gctcttgtgg      960

gctcctatgg cacctcccca gagggtatcg gaggctacat ccattcccat cggcccctgg     1020

gcccaggaga gtttgagtcc ttcattgatg tctatgccat ccggagtgct gaaggagccc     1080

cccagaagga ggtctacttc atgggcctca ttgatatcct tacacagtat gatgctaaga     1140

agaaagcagc tcatgcagcc aaaactgtca agcatggggc tggggcagag atctctactg     1200

tccatccgga gcagtatgct aagcgattcc tggattttat taccaacatc tttgcctaag     1260

agactgcctg gttctctctg atgttcaagg tggtggggtt ctgagacact tgggggaatt     1320

gtggggatat tctagccacc agttctcttc ttcctttgct aaattcaggc tgcaggctcc     1380

ttccatccag ataactccat cctgtcgagt aggctctttc tgaccctcag aaatacattg     1440

tcctttttcc tctttgccca tttttcttcc ctctcttcct ccccatgaga agtctgcttg     1500

tagtattaga atgttattgt tgactctctc cc                                   1532


<210> 4527
<211> 832
<212> DNA
<213> Homo sapiens

<400> 4527
aaaattgaag tgattgaaat catgactgac cgaggcagtg gcaagaaaag gggctttgcc       60

tttgtaacct ttgacgacca tgactccgtg gataagattg tcattcagaa ataccatact      120

gtgaatggcc acaactgtga agttagaaaa gccctgtcaa agcaagagat ggctagtgct      180

tcatccagcc aaagaggtcg aagtggttct ggaaactttg gtggtggtcg tggaggtggt      240

ttcggtggga atgacaactt cggtcgtgga ggaaacttca gtggtcgtgg tggctttggt      300

ggcagccgtg gtggtggtgg atatggtggc agtggggatg gctataatgg atttggtaat      360

gatggaagca attttggagg tggtggaagc tacaatgatt ttgggaatta caacaatcag      420

tcttcaaatt ttggacccat gaagggagga aattttggag gcagaagctc tggcccctat      480

ggcggtggag gccaatactt tgcaaaacca cgaaaccaag gtggctatgg cggttccagc      540

agcagcagta gctatggcag tggcagaaga ttttaattag gtaagtaagc acctttttgt      600

gtgttgacat aattttttaa attgctgatg aacccaataa ccctaatgta gctgagcagt      660

gcaacatagt taacattata attgcagtaa ttgtggatat aaagttaata ttcagatcag      720

caaaatttgt gggaaacaaa cttgatattg gattgtagcc ttgagtctta atatgtttag      780

attaacaact ttattccata ttgttcaaca ggaaacaaag cttagcagga ga              832


<210> 4528
<211> 618
<212> DNA
<213> Homo sapiens

<400> 4528
acatttaaga aatacattgg ttcagtccag aaaggcagga caacccgacg cgaggcaggg       60

agcttccagg ttatagcaat ggagcttacc atctttatcc tgagactggc catttacatc      120

ctgacatttc ccttgtacct gctgaacttt ctgggcttgt ggagctggat atgcaaaaaa      180

tggttcccct acttcttggt gaggttcact gtgatataca acgaacagat ggcaagcaag      240

aagcgggagc tcttcagtaa cctgcaggag tttgcgggcc cctccgggaa actctccctg      300

ctggaagtgg gctgtggcac gggggccaac ttcaagttct acccacctgg gtgcagggtg      360

acctgtattg accccaaccc caactttgag aagtttttga tcaagagcat tgcagagaac      420

cgacacctgc agtttgagcg ctttgtggta gctgccgggg agaacatgca ccaggtggct      480

gatggctctg tggatgtggt ggtctgcacc ctggtgctgt gctctgtgaa gaaccaggag      540

cggattctcc gcgaggtgtg cagagtgctg agaccgggag gggctttcta tttcatggag      600

catgtggcag ctgagtgt                                                    618


<210> 4529
<211> 9646
<212> DNA
<213> Homo sapiens

<400> 4529
gagtccagcg ggttacctgg cggcgggcgg gcgcggccgg gagcggaggg ccgcggtcgc       60

gaagaggatg aagagagagt tcccgaacaa gtcggaagca gctcacaaca ccggacgccg      120

cgcggcaggg ctgtggacct ggggtggttt cgtgtcccag tcttaggaaa ctacgcgcga      180

ggcaccgtgc tgaggcgtag aggtcaccct cgggaggttt cggtgaaacc tggtgggaaa      240

ttccgggcag gcgcccggag tcgcgcccaa gtaggcagct ccgtgccgcc agacttgtgt      300

tcgggggagt tgagacgaac tgcacgggtg ggattgcatg gctctgccct cccagcgttg      360

acaactcgcc ccgaccgccc aggaagcgcg agcttactgg ctccagaagt gatgatgctg      420

ggtggaagtc gcagcatgtg aagagttgcc ggttgttatg ggattaaaaa agatgaaagg      480

gttatcttat gatgaggctt ttgctatggc taatgatccc ttggaaggct tccatgaagt      540

aaaccttgct tcacctactt ctccggacct tcttggtgtg tatgaatcag gaactcaaga      600

gcagactacc tcaccaagtg tcatctaccg gccacaccct tcagctttat cctctgtacc      660

tatccaggca aatgcattag atgtttctga acttcctaca caacccgtgt attcatcccc      720

cagacgttta aattgtgcgg aaatatctag tatcagcttt catgttacag acccagcccc      780

ttgctctacc tctggagtca cagctggatt aactaaatta actacaagaa aggacaacta      840

taatgcagag agagagtttt tacagggtgc tactataaca gaggcttgcg atggcagtga      900

tgatattttt gggttgagta ctgatagtct gtctcgttta cgaagcccat ctgttttgga      960

agttagagaa aagggctatg aacgattaaa agaagaactc gcaaaagctc agagggaact     1020

gaagttaaaa gatgaagaat gtgagaggct ttcaaaagtg cgagatcaac ttggacagga     1080

attggaagaa ctcacagcta gtctatttga ggaagctcat aaaatggtga gagaagcaaa     1140

tatcaagcag gcaacagcag aaaaacagct aaaagaagca caaggaaaaa ttgatgtact     1200

tcaagctgaa gtagctgcat tgaagacact tgtattgtcc agttctccaa catcacctac     1260

gcaggagcct ttgccaggtg gaaagacacc ttttaaaaag gggcatacaa gaaataaaag     1320

cacaagcagt gctatgagtg gcagtcatca ggacctcagt gtgatacagc caattgtaaa     1380

agactgcaaa gaggctgact tatccttgta taatgaattc cgattgtgga aggatgagcc     1440

cacaatggac aggacgtgtc ctttcttaga caaaatctac caggaagata tctttccatg     1500

tttaacattc tcaaaaagtg agttggcttc agctgttctg gaggctgtgg aaaacaatac     1560

tctaagcatt gaaccagtgg gattacaacc tatccggttt gtgaaagctt ctgcagttga     1620

atgcggagga ccaaaaaaat gtgctctcac tggccagagt aagtcctgta aacacagaat     1680

taaattaggg gactcaagca actattatta tatttctcct ttttgcagat acaggatcac     1740

ttctgtatgt aactttttta catacattcg atacattcag cagggactcg tgaaacagca     1800

ggatgttgat cagatgtttt gggaggttat gcagttgaga aaagagatgt cattggcaaa     1860

gctgggttat ttcaaagagg aactctgatg ctctgcgtgg gaccatgcct gaactccccg     1920

aataactgaa aaatggctga atatttttat ggttacttga tatttatttc caaggagtga     1980

gcctaagact tttttcccct tttgcaaatt gctctaagaa gtaccatgat ttcttttaaa     2040

ctgatctatg ctgtgtttgc ttattcttta gttgaacaca ctatgaagaa ttccaggtgt     2100

actagtgaat gtaatttata gttgccaaaa aaaaaaaaaa cctgaaataa ataaatgtta     2160

gattgaatgt gtgtacattt tctcttctag ctctgacatg gcatttaggg ttagcagaat     2220

gtattaaata gtaattttca aactacacag tagcttcctt ccttgtgaga ggcaagaaag     2280

aagtctgagt ggatagtact cactttccaa ggcccccacc tctagaatgg ctttattttt     2340

atctgttttc tatattgggt ttcaaaaaag attttatttg aagaaatact tctgctgcta     2400

caaagtttga aagttactat tttaattatt ctgctctctg taactgaaag aatcccttta     2460

ttttggttat tcattaaaat ataatagaag gcagtcagat tttatcccag agatgtattc     2520

ctgagtgtct tgatatagtg tattcatgtt ttatatgtgt tgaccactat attgtcattg     2580

gagggacata gatgtaaatg agtttgacgt gtgtcaaagg ggtttaaagg ggtgtggatt     2640

gaatgaatgg tacgtgcgaa gtatatgctg attatagaac cacttgatct ctgcattcca     2700

aattgtaaaa ctgactcaac tggagaaatt ataacaaaga ggtttgtggt agacatgtaa     2760

taagtataga aaagcaaaaa gaaaagagaa actgctttag tttctgttta gagaaagctg     2820

ctgttaatat ttttggatag tagcctttca gctttcagat attttctact tacatatgca     2880

tatttttgaa acaaaaagta ggcttttttt ttgcttttta aacctaaaca ttaaatatat     2940

tttcccttgg gtaaacctac acatcctaat ccctgtttat agaattttaa cataatttaa     3000

ttgtgtttgg agatgaggtg gttttcagtt tatttttcat attataatgc tgtgacgagt     3060

atccttatct gtacacttct gaacattgtg gagttctttc atgtggatgc ctggagataa     3120

aattgtgtcg agatatatat gtatttttaa atgtttgatc tgcattgcta gattgccatc     3180

cagaaaagtt aatcaatttg tattcacagc agcagtgtac aagagggctg gttttctgaa     3240

gataacattt ttttcagtcc tgttcagagg tttggtcaat cttacctgta gatgacttca     3300

gccaccaggc tggatgggag cccacagaca aaaggacatt ggtgtatgtt atggtgaaaa     3360

ccatcagtac catgcctagc tcaagaatgt gaaattgaac ctgaaaaaaa ctttgaacct     3420

acaattttat gttctgaaaa tagttattct aatgtgaggg cattaataag aatatgtacc     3480

atcaaagctt cagaagattt tccgtacaaa ctaaaatcac ttttggagaa agtacctaaa     3540

taaaaagaga aacaaatcca ggagatactg tacggtttga aagaaaggta atcaaatact     3600

cagaaaaagt ttgttgatga cttaaaaagg ataaataaaa agtaagacta aagaaaatca     3660

gtatacccat taataataaa tctttagtaa tctataaggg gaagaatgct tttcaacctt     3720

atacactaga agcatgctct ttaaaattaa tgcaacagga tgacgacttg atgtagaaac     3780

tatatgtgga attatagatt aaaatgtgat tgaaacatat ttagaaaatg tgattatctt     3840

cctgatccta ctccctttag gaagaacttc ttaaactgga agcaggaaaa aaaaaaacca     3900

taaaagataa ccataaaaga atataagtta tggtatatta taaattctta atttagaaat     3960

cgtgcatcag tagttaggca ttgtggctca tgcctgtaat cccagcactt tgggaggcag     4020

aggcagaagg attacttgag ctgcttgagc ccaggagttt gagacgggcc tgggaaaaat     4080

agggaaactc catttacaca cacacacaca cacacacaca cacacacact gtgtccatga     4140

acttgggagg atgaggtggg aggattgctt gagcccaggg gttcaagtcc aacttgggca     4200

acatagggag accttgtctc taaaaaaaaa actaaagcta aactacaaac tgtgaggcaa     4260

tatctgcaac atttataact agtaatagct tagtatcaag aatgtatgca gaaattctac     4320

aaaccaacaa aaaaggacag tgtcacagaa aaacaggcaa aagactgaac caggccttcc     4380

acacaattag aagtgcatgt gggccaataa acattaagag gttttcatct ctcaatcagg     4440

aaaacgtaaa tcaagatgac aatgacatgt tcaaattcat tcgattggtg aaaatgaaga     4500

aacacaaagt caagttttgg agagggtttt agtcattagg atcactcaca tattgctgat     4560

gggggtatca attggtatat ccactgtgaa aaaccattca ctagaaaagt tgggccaggc     4620

ccagtggctc atgcctcttg gctttgggag gccaaggtag gaggatcact tgagcccaag     4680

agttcaagac cagcttgagc aacataggga gaccacatct gcacaaaaag atttttttga     4740

attagctggg catggtggtg catgcctgtg gtcccagcta cttgggaagc tgaggtggaa     4800

ggattgctta agcccaggag gttgaggctg cagtgaatca tgattgtgcc actgcactct     4860

taccttgggt gacagagtaa gatcatacct taaaaaaaaa aaaaaagtat acccatgggt     4920

cagcaatttc acttttcagt atatacttga gaaatgcttg cacaggtccc ccagatcaca     4980

catataagaa tgttctggaa taaattaaaa tgtctatttt taggaaggtg taatgtgttc     5040

acagaatggg tgattattac atggcagcaa aatgaatgaa taccagctac ttgcagcaca     5100

ataactcaga atgaaaaagc aattctgaga aaactatatg tgacatgata cttttcttat     5160

aaaagtcaag aacaactaaa actgaacagc tgtttaggca ttgacatatg tgacaaaact     5220

tttaaaaagt aataaagttc aagatagtgg ttacctctgg agaggtagag gaggagcaaa     5280

tctatgagta agtcactggt aatgttttag tccctgggtt aggtggtggg ttttggggtg     5340

gttcatttgt cattaaaagt aagtacatga gctgggtgta gtggtgcgtg cttatagtcc     5400

cagctacttg ggagtctgag ataggaagat ccttgaggcc agttcaaggc tatagtgtgc     5460

tatgatttca cctgtgaata gctactatat tccaacctgg gcaacgtaga ccttgccccc     5520

ctttaaaaaa attcaaaaac aaaataaatg catggacaaa tgaataagag agttatgcat     5580

ggaacatcgg tggtgtatta tgaatcaagc attattacta gctcagttat atgtgccttc     5640

attccaaaac aaaaaataaa aggtaagaaa attgttgaat tgcatttgag agagaggaaa     5700

ggaaagaatt caggtctgaa tcttaggctt ttggcttgag ctattgcagt ttattgagat     5760

ggggaaatac atggtgggga aagtttgggt atgtgcataa cagagacaga aattcagtgt     5820

ttgacagatc aagtgtgagg tgcccactga gcatcaaagt ggatatgtta agcaggtatt     5880

ggatgtacaa atctaaattc agtaaggtca gtccaggaga aaatttgggg agtagttagc     5940

catgggatca gatgggcgct ttagggacac tttggagatg aagtacagca ctgagccctg     6000

agttcctgtg acagagaagc agcctgcaaa gacgaaagga ggagctgtta ggaagagcaa     6060

ggcaacagaa aaggaagaac cagcatgctg attatgttca ggagagtgtt tctacgctga     6120

atttaattgc caagattacc aattctaaag aagaggagga ctcttggaca agtttttaga     6180

agttggtttg gagctggggt gagagcctgg cctaatggag acagctctgg attgggagtc     6240

acttagacct acattctggt ctaggtttgg ctcccaaaaa ctgggaaggt tagttaggtg     6300

gccactcctc tctcttcatg gtctctctca gcttgaagac aatttacagt ctttgactaa     6360

gcatccacac tggaagaaca agatttggtt tctgaacatt gggtcttagt ccttaaaata     6420

acttgcaacc tgttacgtct tcacttactc ccatcgccac cacaagaatc ctgtgtgttt     6480

ttgttttgtg catccagtct aaaacgggtc tgcttttatt cataggcttt tgttttcagt     6540

ggtttttgtt gttgcatttt tccctagata aaatgttttt tctataagac actgcttaaa     6600

agagtccaat gcagtatgaa tttgtatttg tgtttaactt ttgtgcttaa cagatctgcc     6660

atggctgaac tctcagttgc ttaagcaaaa ttctggggct tattctaggt tcctttattt     6720

gtcattgtca ctcccattcc agttatcagc aaattccatc agctgtctcc gagacatctt     6780

aaatctgtct acctccctcc atgtccactg ctaccactct gcccaagcta ttatcatctt     6840

tcacctgaac tcctgcacta atgtctgctg tccttgcatc cactcctgcc ctcctacaat     6900

cactgacggc agccgcaggg atctttataa aacgaaaatc agataatgtc acttccctgc     6960

ttaaagccct ttgagtggct tcccattgca cttagaaaaa aaaaaaaaaa aaaaaactgg     7020

ccaggtgcga tggctcatgc ctgtaatccc agcactttgg gaggccgagg cgggcggatc     7080

ccctgaggtt ggtagttcga gacctgcttg gccaacatgg agaaaccctg tctctactaa     7140

aaacacaaaa ttagtcaggt gtgatggcgc atgcctgtaa tcccagctac ttgggaggct     7200

gagtcaggag aaacgctcga acccaggagg cagaggttgt ggtgagttga catcacgcca     7260

ttgcactcca gcctgggcaa caagagtgaa actccgtctg aaaaaaaaaa aaaaaaaccc     7320

aaactcaata gaaaatcaag ttttcatagt ggtagttgtt aacagagaaa taacaatgaa     7380

agctttaaaa aactccatga aaatttgcaa aacttaaaaa aaaaatgtag aagaggacta     7440

aacttgataa aatattaaaa gaattgaaac ccttcctaaa ggcagcttct caagggagca     7500

caagttcaca cacagtttac ttttggagga acgtctgagg tcatgaggac tagattctag     7560

agctacaggt ctcagggaca gtctcgaggg atacagggcc cccatcacca catccccaga     7620

tttaaccgca gcagctcagc ttttatctgt atctgttgga gctctctagg aaatgtcaat     7680

accaaagcaa acccaaatca caactagatt agattactat tcaagagaat gattctctac     7740

cgaaactctg caaaatgggg atatcaagag agttggaaaa tgtaagacgt aaagaccata     7800

atcaggaaaa tacgcatcat atttgttatt cactgagagg gaggaatttc cacttaaatc     7860

ctatttccag cagctggatt gtgctctcag tggagtgctc tggattctga ttaatagaga     7920

ttttctagtc ctcccagcaa cttccttctc aattctcttc actttccgca gatctcggca     7980

ccagggttgc atcttgtggg ctccattgtg ttttcacaca atgtgctatt tgtccttcac     8040

agtgttttgg tttatttttc tgtttgtcca tcttgttttt gaacaattgc cagcatttaa     8100

aaatgaggaa atctaaaatc tgcatttcaa gctgctcttt tttaaaatgt gccgtttcga     8160

caacactgag cccacagtct tgaatgacaa cacttgggtg gagctgagtg actccacctg     8220

tcgggtggct acacccttgc tcagggtatg cactccatgg tttgctctat ggcccaccat     8280

cctggattgt ctccctgaca ccaaggctaa gggacccact ttactcactt atctgctggg     8340

ccttggaagt atttcagttc ggaaccccaa ttctaacctt agcttctcag gccattaaat     8400

gaaatctcat ttctatgatg cttcctgtca catcactgtg ctgctgagaa catgaagtct     8460

gtgggtgaat tggtggacgg gatccagaat cattacttgg cagtggatta tagtgtgatg     8520

actcatttcc ggtggtctcc aggagacttg gctgggagct tctcttggag tctagggtta     8580

gccagaggct acatgtttta ggcatcttaa ttcatatttt atctaaaggc atataaatcc     8640

ttaaaaaaaa tcatttgact tcatccttgc tccctacatc cagccagtaa ccattgcttt     8700

gttttacatc gcgtgcttca ggctttacta cagcctacct ggattttgca gtagcttctt     8760

aaactgctta aactttggat attgccccag ccaacacatt ctgccacaga gatctctctg     8820

agttaaatgg gattgtatca tgccccacac ccaagcagat agaaactgtc aatagataca     8880

cttagaatga atatgcatgg aatcaaatta cattcagaat ctaccactat aggtagtgaa     8940

tacaacagga tagcagaggc tgggaagggt aatgggggtt ggggggtggg aggataaagg     9000

ggttgggtaa tgggtgtaaa aatctataga aggaatatga tctgttgttt ggtagcacaa     9060

tagggtaaat acagttaata atttattgta tatttcacaa taaaggagtg gatttggaat     9120

gttctcaaca caaatgataa atgtttgagg tgatggatac cccaattacc ctgatttgat     9180

cattatacgt tgtatgtttg tatcaaaata tcatatgtac cccataaata tgtacaacta     9240

ttatgtatcc ataaaaattg gaaataaact accaccatct ttcttcagcc tattttccta     9300

tctcctctcg caccatacta ggcacacaat ctctgtacct gtgctgtctt ccaagccatt     9360

gctcatgttt taagaaatat acttattgtt taatatatcc tgtaccactg taggatgact     9420

gtagttaaca ataatgtgta gtttcaaata gctaatagct ggaaggaagt tgttgaatgt     9480

ttccaacata aagaaatgat aagtgtttga gatgatggat atgctaatta ccctgatctg     9540

atcactacac attatatgta tggaaatatc attgtgtacc ccatgaatat gggcaattat     9600

tatttgttaa ttaaaaaaat aaaaaaaaga cccacccact gtttaa                    9646


<210> 4530
<211> 551
<212> DNA
<213> Homo sapiens

<400> 4530
gttttcaaac cggagctgtg ggcgcggcgc tgctctgccg ttgggtgagg cgcggagcga       60

agtgaagggt ggcccaggtg gggccaggct gactgaatgt atctcctagc tatggactaa      120

ataatacatg gggggaaata aacaagtatt catgagggtg aaaatgtgac ccagcaggaa      180

aattacaact attttcaatt gacgttgaat aggaaagatg gatactatga tgctgaatgt      240

gcggaatctg tttgagcagc ttgtgcgccg ggtggagatt ctcagtgaag gaaatgaagt      300

ccaatttatc cagttggcga aggactttga ggatttccgt aaaaagtggc agaggactga      360

ccatgagctg gggaaataca aggatctttt gatgaaagca gagactgagc gaagtgctct      420

ggatgttaag ctgaagcatg cacgtaatca ggtggatgta gagatcaaac ggagacagag      480

agctgaggct gactgcgaaa agctggaacg acagattcag ctgattcgag agatgctcat      540

gtgtgacaca t                                                           551


<210> 4531
<211> 2829
<212> DNA
<213> Homo sapiens

<400> 4531
cttgttctct gtagctttca atcctttata catagtgttc ctttttttta aatactgtct       60

tccccttgtt catcttccac ctaactgttc ttactaatcc ttcgtgatta gcttagatat      120

caatttctcc aggaaattgt ccccactgat ccccaagcct gggttaggtt cccgggagtc      180

ctgtgtgcct tctgtaacac cttgtgtttt cctatcatag ctctcagcag cctgtttact      240

tgtctgaaca ttacttgaga ggaagaattt ttggctgttt tattcactat tgtctcccca      300

gctcctaaca aagaacctgg cacacagctc aatacatggt agctattatt attatcagca      360

ccttcatcta tcataattct caaatgtctg gttgttgcat aaataactct taagtatgcc      420

aagaagctta gagttaagtt acaagactga caagggcatg cattgtttca gagccatgtt      480

tgggaccttt gtttttcact tattcaatca ttttcccttt ttatactagg aactgaccca      540

ggagtgtgat gaaaagaaat cccagtatga tagctgtgca gcaggcctcg aaagcaatcg      600

gtccaaatta gaacaggtaa gaagagagtt tttattttaa caatttagca aaaactacct      660

gtgtgtacac ctgtagtccc agctactctg gaggctgaag caggaggatt gcttgagcct      720

aggagtttga ggctacagtg agctatgatc acaccactgc attctagcct gggccacaga      780

gcaagactct ctctctaaaa aaaatgtttt aaatactgcc cgtgtacgca cattttcact      840

acatcaatgt caaaagattc ccaaatcttt atcatcatct cctaagctcc agagatcttt      900

atttctttaa tttgtacaca cttaatttcc catctgtacc actcccagca aagtacaagg      960

ctcattatct gctgcctggc ctcccacagt aaactcttac ctattctctt gcttctactc     1020

ttgctctcct aaggtttatt cttcataggg aagcctaaga aacctgttta aaatttttgc     1080

cacccttcat tggcttcctg ttgcacttaa aataaaatct aaccaccaaa ctatggtcta     1140

caaggcccca cctgccttat gaacttcatg tccatgtgct ctactcctca tccatggagc     1200

ttcagccact ctgaccttct tcctgagctt taaacaggcc aagcttgttt tcactttggg     1260

attttgcatg tactcttccc ttctgcgtga tatactctgc tcctaactct tcgccctccc     1320

ttctcctttt catcactagg tctcagcctt agtgtcactg cctttcagag atctctgatc     1380

acctgatgtt acccactctt cttcccaacc tggcccaccc agtccctcta tcacattcta     1440

ctgatggatt tccttcatag cgcttatccc catctcaaat atccttcatt atgtttcctt     1500

gtttatgttg gtttcttcta cttcagtgaa agcagggaac ctgcctgttc acttctgtgt     1560

cctcagcact tagaacagtg ctggacacac agtaggtact taataaatgt atgattgggc     1620

cagatgcagt cgctcatgcc tgtaatccca gcactttggg agtccagggc gggaggatca     1680

cttgaggcta ggagttcgag atcagcctgg ccaacccggt gaaaccctgt ctctactaaa     1740

aatacaaaaa ttagccaggc gtggtggcac gtgcctgtag tctcagctcc tcaggaggct     1800

gaggcacgag aatctcttga acctgcgagg aggaggttgc agtgagccaa gactgcacca     1860

ctgcactcca tcctgagtga cagagtgaga ctctgtctca aaaaatacaa ttgaacttgc     1920

aggttataga gtgatatgtg tattctctag aaaaagatta tctcttattg tgctagaata     1980

aacaaagtta aaattgcaga agaggaaatg actctgatgg tagtcctttg ttgtacatct     2040

aaagtcatcg tcgccatatc tgtctcattc tttcgataat gtcacctatc taaaattata     2100

tattatagga agttagaaga ctccgtgaag aatgtcttca agaagaaagt agataccatt     2160

atacaaattg tatgattaag aacctagaag ttcaacttcg tcgtgctact gatgagatga     2220

aggcatatat ctcttctgat caacaagaaa aaagaaaggc aattagggaa cagtatacca     2280

aaaatactgc tgaacaagaa aaccttggaa agaaacttcg ggaaaaacaa aaagttatac     2340

gagaaagtca tggtccaaat atgaaacaag caaaaatgtg gcgtgatttg gaacaattaa     2400

tggaatgtaa gaaacagtgc tttctgaaac aacaaagcca aacttccatt ggtcaggtaa     2460

ttcaggaggg tggggaggac cggctaatac tgtgaattct tgtgtcatcg tttggggttt     2520

tacttgatac cactagctat aagcctaatc tcataatgta tttctttttt gaaactgatt     2580

tgtatagcat tttgttttca gaagagccat tctttattaa gttttcatag aaaataatgt     2640

taaggtagat ttagtttgaa tgttttttca tatgaaaaag aggcttttat tcttttccat     2700

agtttagaca tcactggcgt cttctgagtt ttatgagaca ggaaactaag tttactatct     2760

gtaaatgtaa acatatgtcc attaagaaac atgtagtttt tttttagaat gtaataaccc     2820

agtggctta                                                             2829


<210> 4532
<211> 3377
<212> DNA
<213> Homo sapiens

<400> 4532
gccagctgct gcgcatgcgc cggccggggc cccgccccca tgcgccgcgc ggctccaggg       60

ccacgttcca gggtcgggtt tggtggattc ctcagtccct gccgccgcgg ggcgccctgg      120

gatagcggcg gggcctcctg tcacctgcag aatccattaa ggcctggagg cctaaggagt      180

tagtattgta tgaaatccct acgaaacccg gtgaaaagaa agatgtctct gggcccctgc      240

ctcctgcata cagcccccga tatgttgagg ctgcctggta cccgtggtgg gtacgagagg      300

gcttcttcaa accagaatat caggcccggc tgccccaagc tacaggggag accttttcca      360

tgtgtatccc acctcccaat gtcactggct ccctgcacat tggccacgca ctcacggtgg      420

ccatacagga tgccctcgtg cgctggcacc ggatgcgtgg ggatcaagtg ctgtgggtcc      480

ctggttcaga tcatgcagga attgctacac aagctgtggt ggagaaacaa ctgtggaagg      540

aacggggagt gaggagacat gagctgagcc gggaggcctt ccttagggag gtgtggcagt      600

ggaaggaggc gaaaggtgga gagatctgtg agcagctgcg agctctgggt gcctccctgg      660

actgggatcg agagtgtttt accatggatg ttggctcctc agtggctgtg actgaagctt      720

ttgtgcggct ctacaaggcg gggttgctgt accggaacca tcagcttgtc aactggtcat      780

gtgctttaag atcagccatc tcggacattg aggtggagaa ccggcccctg cctggccaca      840

cacagcttcg actgcctggc tgccccaccc ccgtgtcttt tggcctccta ttttctgttg      900

ccttccccgt ggatggagag cctgatgcag aggttgtggt aggaaccaca aggccagaga      960

cgctgcctgg agatgtggct gtggccgttc atccagacga ctcgcgatac acacatctac     1020

acgggcgaca gcttcgtcac cccttgatgg ggcagcctct tcccctcatc acagactatg     1080

ctgttcagcc acatgtgggc acgggggcag tgaaggtgac tccagctcac agtcctgccg     1140

atgctgagat gggggcccga catggcttga gccccttgaa tgtcattgcg gaggatggga     1200

ccatgacctc cctctgcggg gactggttgc agggtcttca ccggtttgtg gcccgggaaa     1260

agataatgtc tgtgctgagt gaacggggcc tattccgggg cctccagaac caccccatgg     1320

tactgcccat ctgcagccgt tctggggatg tgatagaata cctgctgaag aaccagtggt     1380

ttgtccgctg ccaggaaatg ggggcccgag ctgccaaggc tgtggagtcg ggggccctgg     1440

agctcagtcc ctccttccac cagaagaact ggcagcactg gttttcccat attggggact     1500

ggtgtgtctc ccggcagctg tggtggggcc atcagattcc agcctacctg gttgtagagg     1560

accatgcgca gggagaagag gactgttggg tggttgggcg gtcagaggct gaggccagag     1620

aggtagcagc ggaactgaca gggaggccag gggcagagct gaccctggag agggatcctg     1680

atgtcctaga cacatggttt tcttctgccc tgttcccctt ttctgccctg ggctggcccc     1740

aagagacccc agaccttgct cgtttctacc ccctgtcact tttggaaacg ggcagcgacc     1800

ttctgctgtt ctgggtgggc cgcatggtca tgttggggac ccagctcaca gggcagctgc     1860

ccttcagcaa ggtgcttctt catcccatgg ttcgggacag gcagggccgg aagatgagca     1920

agtccctggg gaatgtgctg gacccaagag acatcatcag tggggtggag atgcagttgc     1980

tgcaggaaaa gctgagaagc ggaaatttgg accctgcaga gctggccatt gtggctgcag     2040

cacagaaaaa ggactttcct cacgggatcc ctgagtgtgg gacagatgcc ctgagattca     2100

cactctgctc ccatggagtt caggcgggcg acttgcacct gtcagtctct gaggtccaga     2160

gctgccgaca tttctgcaac aagatctgga atgctcttcg ctttatcctc aatgctttag     2220

gggagaaatt tgtgccacag cctgctgagg agctgtctcc ctcctccccg atggatgcct     2280

ggatcctgag ccgccttgcc ctggctgccc aggagtgtga gcggggcttc ctcacccgag     2340

agctctcgct cgtcactcat gccctgcacc acttctggct tcacaacctc tgtgacgtct     2400

acctggaggc tgtgaagccc gtgctgtggc actcgccccg ccccctgggg ccccctcagg     2460

tcctgttctc ctgcgctgac ctcggcctcc gcctcctggc cccactgatg cccttcctgg     2520

ctgaagagct ctggcagagg ctgcccccca ggcctggttg cccccctgcc cccagcatct     2580

cggttgcccc ctaccctagc gcctgcagct tggagcactg gcgccagcca gagctggagc     2640

ggcgcttctc ccgggtccaa gaggtcgtgc aggtgctaag ggctctccga gccacgtacc     2700

agctcaccaa agcccggccc cgagtgctgc tgcagagctc agagcctggg gaccagggcc     2760

tcttcgaggc cttcttggag cccctgggca ccctgggcta ctgtggggct gtgggcctgt     2820

tacccccagg cacagcagct ccctccggct gggcccaggc tccactcagt gacacggctc     2880

aagtctacat ggagctgcag ggcctggtgg acccgcagat ccagctacct ctgttagccg     2940

cccgaaggta caagttgcag aagcagcttg atagcctcac agccaggacc ccatcagaag     3000

gggaggcagg gactcagagg caacaaaagc tttcttccct ccagctggaa ttgtcaaaac     3060

tggacaaggc agcctctcac ctccggcagc tgatggatga gcctccagcc ccagggagcc     3120

cggagctcta actcatcatc cccatcagtt ttcctccctc tcagacctgt ctttgaggac     3180

aaacagattt gtcagctgtc agggtgcagt gggacgtcag agactatgtg gtccatcgcc     3240

ttcattgtgt aaatgaggac acagactggc ttggtcgcag tgactgtggt gtccttgaga     3300

tgctcacatt actgcccggc ctgcctccca cctggaagtc tgggaatgag gagattgaga     3360

taaacttttg aaatccc                                                    3377


<210> 4533
<211> 2291
<212> DNA
<213> Homo sapiens

<400> 4533
ggtgaaaggt gaggggaaca gctgatccgt ctgttgggag gacagatatc tcaaggccag       60

gatggaagaa tcaccactaa gccgggcacc atcccgtggt ggagtcaact ttctcaatgt      120

agcccggacc tacatcccca acaccaaggt ggaatgtcac tacacccttc ccccaggcac      180

catgcccagt gccagtgact ggattggcat cttcaaggtg gaggctgcct gtgttcggga      240

ttaccacaca tttgtgtggt cttccgtgcc tgaaagtaca actgatggtt cccccattca      300

caccagtgtc cagttccaag ccagctacct gcccaaacca ggagctcagc tctaccagtt      360

ccgatatgtg aaccgccagg gccaggtgtg tgggcagagc ccccctttcc agttccgaga      420

gccaaggccc atggatgaac tggtgaccct ggaggaggct gatgggggct ctgacatcct      480

gctggttgtc cccaaggcaa ctgtgttaca gaaccagctc gatgagagcc agcaagaacg      540

gaatgacctg atgcagctga agctacagct ggagggacag gtgacagagc tgaggagccg      600

agtgcaggag ctcgagaggg ctctggcaac tgccaggcag gagcacacgg agctgatgga      660

acagtacaag gggatttccc ggtcccatgg ggagatcaca gaagagaggg acatcctgag      720

ccggcaacag ggagaccatg tggcacgcat cctggagcta gaggatgaca tccagaccat      780

cagtgagaaa gtgctgacga aggaagtgga gctggacagg cttagagaca cagtgaaggc      840

cctgactcgg gaacaagaga agctccttgg gcaactgaaa gaagtacaag cagacaagga      900

gcaaagtgag gctgagctcc aagtggcaca acaggagaac catcacttaa atttggacct      960

gaaggaggcg aagagctggc aagaggagca gagtgctcag gctcagcgac tgaaagacaa     1020

ggtggcccag atgaaggaca ccctaggcca ggcccagcag cgggtggccg agctggagcc     1080

cttgaaggag cagcttcgag gggcccagga gcttgcagcc tcaagccagc agaaagccac     1140

ccttcttggg gaggagttgg ccagtgcagc agcagccagg gaccgcacca tagccgaact     1200

acaccgcagc cgcctggaag tggctgaagt taacggcagg ctggctgagc tcggtttgca     1260

cttgaaggaa gaaaaatgcc aatggagcaa ggagcgggca gggctgctgc agagtgtgga     1320

ggcagagaag gacaagatcc tgaagctgag tgcagagata cttcgattgg agaaggcagt     1380

tcaggaggag aggacccaaa accaagtgtt caagactgag ctggcccggg agaaggattc     1440

tagcctggta cagttgtcag aaagtaagcg ggagctgaca gagctgcggt cagccctgcg     1500

tgtgctccag aaggaaaagg agcagttaca ggaggagaaa caggaattgc tagagtacat     1560

gagaaagcta gaggcccgcc tggagaaggt ggcagatgag aagtggaatg aggatgccac     1620

cacagaggat gaggaggccg ctgtggggct gagctgcccg gcagctctga cagactcaga     1680

ggacgagtcc ccagaagaca tgaggctccc accctatggc ctttgtgagc gtggagaccc     1740

aggctcctct cctgctgggc ctcgagaggc ttctcccctt gttgtcatca gccagccggc     1800

tcccatttct cctcacctct ctgggccagc tgaggacagt agctctgact cggaggctga     1860

agatgagaag tcagtcctga tggcagctgt gcagagtggg ggtgaggagg ccaacttact     1920

gcttcctgaa ctgggcagtg ccttctatga catggccagt ggctttacag tgggtaccct     1980

gtcagaaacc agcactgggg gccctgccac ccccacatgg aaggagtgtc ctatctgtaa     2040

ggagcgcttt cctgctgaga gtgacaagga tgccctggag gaccacatgg atggacactt     2100

ctttttcagc acccaggacc ccttcacctt tgagtgatct tactccctcg tacatgcaca     2160

aatacacact catgcacaca cacactcaca cacatgcata cacttaggtt tcatgcccat     2220

tttctatcac actgggctcc atgatattct gttccctaag aactgcttct gtgtgccctg     2280

ttttcatccc a                                                          2291


<210> 4534
<211> 565
<212> DNA
<213> Homo sapiens

<400> 4534
gaatttgaat cctgtgggcc gttgaatgtg gctgctcgcg gtcggcgtgc cccgacgtac       60

agcgggccgg gaaaagtggc actgaggctc tggaacttct gcccagctct ccttgctaaa      120

aaacattccc ttcaatttaa aaaatgttcc cgactcttaa caccccagtt gagaactact      180

gatcttagat gtattaaagt aaaatgaatg aaagtaaacc tggtgactca cagaaccttg      240

cttgtgtttt ctgtcgaaaa catgatgact gtcctaataa atacggagaa aagaaaacta      300

aggagaaatg gaatctcact gtacattact actgtttgtt gatgtcaagt ggaatttggc      360

agagaggcaa agaagaagaa ggagtttatg gttttctaat agaagatatc aggaaggaag      420

tgaatagagc ttctaaactg aaatgctgtg tttgcaagaa aaatggtgct tcaattggat      480

gtgttgcacc ccgatgtaaa cgaagttatc atttcccatg tggacttcag agagaatgta      540

ttttccagtt tactggcaat tttgc                                            565


<210> 4535
<211> 1010
<212> DNA
<213> Homo sapiens

<400> 4535
cagggtggcc cttgggtagg gtgaagatcc cctgtcttta tcctagttcc acaccttggt       60

gtgggttact gggtgcagga tgaactgtcg ctcggaggtg ctggaggtgt cggtggaggg      120

gcggcaggtg gaggaggcca tgctggctgt gctgcacacg gtgcttctgc accgcagcac      180

aggcaagttc cactacaaga aggagggcac ctactccatt ggcaccgtgg gcacccagga      240

tgttgactgt gacttcatcg acttcactta tgtgcgtgtc tcttctgagg aactggatcg      300

tgccctgcgc aaggttgttg gggagttcaa ggatgcactg cgcaactctg gtggcgatgg      360

gctggggcag atgtccttgg agttctacca gaagaagaag tctcgctggc cattctcaga      420

cgagtgcatc ccatgggaag tgtggacggt caaggtgcat gtggtagccc tggccacgga      480

gcaggagcgg cagatctgcc gggagaaggt gggtgagaaa ctctgcgaga agatcatcaa      540

catcgtggag gtgatgaatc ggcatgagta cttgcccaag atgcccacac agtcggaggt      600

ggataacgtg tttgacacag gcttgcggga cgtgcagccc tacctgtaca agatctcctt      660

ccagatcact gatgccctgg gcacctcagt caccaccacc atgcgcaggc tcatcaaaga      720

cacccttgcc ctctgagcgt cgctggatct ctgggagctc cttgatggct cccagacctt      780

ggcttttggg aattgcactt ttgggccttt gggctctgga acctgctctg ggtcattggt      840

gagacttgga aggggcagcc cccgctggct tcttggtttt gtggttgcca gcctcaggtc      900

atccttttaa tctttgctga cggttcagtc ctgcctctac tgtctctcca tagccctggt      960

ggggtccccc ttctttctcc actgtacaga agagccacca ctgggatggg                1010


<210> 4536
<211> 2193
<212> DNA
<213> Homo sapiens

<400> 4536
gaaagatgga tactatgatg ctgaatgtgc ggaatctgtt tgagcagctt gtgcgccggg       60

tggagattct cagtgaagga aatgaagtcc aatttatcca gttggcgaag gactttgagg      120

atttccgtaa aaagtggcag aggactgacc atgagctggg gaaatacaag gatcttttga      180

tgaaagcaga gactgagcga agtgctctgg atgttaagct gaagcatgca cgtaatcagg      240

tggatgtaga gatcaaacgg agacagagag ctgaggctga ctgcgaaaag ctggaacgac      300

agattcagct gattcgagag atgctcatgt gtgacacatc tggcagcatt caactaagcg      360

aggagcaaaa atcagctctg gcttttctca acagaggcca accatccagc agcaatgctg      420

ggaacaaaag actatcaacc attgatgaat ctggttccat tttatcagat atcagctttg      480

acaagactga tgaatcactg gattgggact cttctttggt gaagactttc aaactgaaga      540

agagagaaaa gaggcgctct actagccgac agtttgttga tggtccccct ggacctgtaa      600

agaaaactcg ttccattggc tctgcagtag accaggggaa tgaatccata gttgcaaaaa      660

ctacagtgac tgttcccaat gatggcgggc ccatcgaagc tgtgtccact attgagactg      720

tgccatattg gaccaggagc cgaaggaaaa caggtacttt acaaccttgg aacagtgact      780

ccaccctgaa cagcaggcag ctggagccaa gaactgagac agacagtgtg ggcacgccac      840

agagtaatgg agggatgcgc ctgcatgact ttgtttctaa gacggttatt aaacctgaat      900

cctgtgttcc atgtggaaag cggataaaat ttggcaaatt atctctgaag tgtcgagact      960

gtcgtgtggt ctctcatcca gaatgtcggg accgctgtcc ccttccctgc attcctaccc     1020

tgataggaac acctgtcaag attggagagg gaatgctggc agactttgtg tcccagactt     1080

ctccaatgat cccctccatt gttgtgcatt gtgtaaatga gattgagcaa agaggtctga     1140

ctgagacagg cctgtatagg atctctggct gtgaccgcac agtaaaagag ctgaaagaga     1200

aattcctcag agtgaaaact gtacccctcc tcagcaaagt ggatgatatc catgctatct     1260

gtagccttct aaaagacttt cttcgaaacc tcaaagaacc tcttctgacc tttcgcctta     1320

acagagcctt tatggaagca gcagaaatca cagatgaaga caacagcata gctgccatgt     1380

accaagctgt tggtgaactg ccccaggcca acagggacac attagctttc ctcatgattc     1440

acttgcagag agtggctcag agtccacata ctaaaatgga tgttgccaat ctggctaaag     1500

tctttggccc tacaatagtg gcccatgctg tgcccaatcc agacccagtg acaatgttac     1560

aggacatcaa gcgtcaaccc aaggtggttg agcgcctgct ttccttgcct ctggagtatt     1620

ggagtcagtt catgatggtg gagcaagaga acattgaccc cctacatgtc attgaaaact     1680

caaatgcctt ttcaacacca cagacaccag atattaaagt gagtttactg ggacctgtga     1740

ccactcctga acatcagctt ctcaagactc cttcatctag ttccctgtca cagagagtcc     1800

gttccaccct caccaagaac actcctagat ttgggagcaa aagcaagtct gccactaacc     1860

taggacgaca aggcaacttt tttgcttctc caatgctcaa gtgaagtcac atctgcctgt     1920

tacttcccag cattgactga ctataagaaa ggacacatct gtactctgct ctgcagcctc     1980

ctgtactcat tactactttt agcattctcc aggcttttac tcaagtttaa ttgtgcatga     2040

gggttttatt aaaactatat atatctcccc ttccttctcc tcaagtcaca taatatcagc     2100

actttgtgct ggtcattgtt gggagctttt agatgagaca tctttccagg ggtagaaggg     2160

ttagtatgga attggttgtg attctttttg ggg                                  2193


<210> 4537
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 4537
atggccacca tcccagactg gaagctacag ctgctagccc ggcgccggca ggaggaggcg       60

tccgttcgag gccgagagaa agcagaacgg gagcgcctgt cccagatgcc agcctggaaa      120

cgagggctcc tggagcgccg ccgggccaag cttgggctgt cccctgggga gcctagccct      180

gtgctaggga ctgtagaggc tggacctcca gacccggatg agtctgcggt ccttctggag      240

gccatcgggc cagtgcacca gaaccgattc atccggcagg agcggcagca gcagcagcag      300

caacaacaac ggagtgaaga gctgctagca gagagaaagc ctgggcctct ggaggcccgg      360

gagcggagac ccagccctgg ggagatgcgg gatcagagcc ccaagggaag agagtcaaga      420

gaagagagac taagtccgag ggagaccaga gagaggaggc tggggatagg gggagcccaa      480

gagttgagcc tgaggcctct ggaggctcgg gactggaggc aaagcccagg agaggtggga      540

gacaggagct cccgactgtc agaggcatgg aaatggaggc tgagtcctgg agaaactcca      600

gagcggagtc tgagactagc agagtctcga gagcaaagcc ccaggagaaa agaggtggaa      660

agtagactga gcccagggga atctgcctac cagaagttgg gcctgacaga ggcccataaa      720

tggagacctg actccagaga gtctcaggaa cagagtttgg tacaactgga ggcaacagag      780

tggaggctga ggtcaggaga agaaagacaa gactactcgg aagaatgtgg gagaaaagaa      840

gagtggccag ttccaggggt agctccaaaa gagactgcag agctgtccga gaccctgaca      900

agggaggccc aaggcaacag ttccgcagga gtggaggcag cagagcagag gcctgtggaa      960

gatggcgaga ggggcatgaa gccaacagaa gggtggaaat ggaccctgat aatgagcctg     1020

gcagggaagg gcaaccaaca tcttgtaact tgctttcccc accctgtttc tgggggcaga     1080

gccaattgcc caatttctac cctaatccaa agtccctggt gtgggtgggg ttaa           1134


<210> 4538
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 4538
atggccacca tcccagactg gaagctacag ctgctagccc ggcgccggca ggaggaggcg       60

tccgttcgag gccgagagaa agcagaacgg gagcgcctgt cccagatgcc agcctggaaa      120

cgagggctcc tggagcgccg ccgggccaag cttgggctgt cccctgggga gcctagccct      180

gtgctaggga ctgtagaggc tggacctcca gacccggatg agtctgcggt ccttctggag      240

gccatcgggc cagtgcacca gaaccgattc atccggcagg agcggcagca gcagcagcag      300

caacaacaac ggagtgaaga gctgctagca gagagaaagc ctgggcctct ggaggcccgg      360

gagcggagac ccagccctgg ggagatgcgg gatcagagcc ccaagggaag agagtcaaga      420

gaagagagac taagtccgag ggagaccaga gagaggaggc tggggatagg gggagcccaa      480

gagttgagcc tgaggcctct ggaggctcgg gactggaggc aaagcccagg agaggtggga      540

gacaggagct cccgactgtc agaggcatgg aaatggaggc tgagtcctgg agaaactcca      600

gagcggagtc tgagactagc agagtctcga gagcaaagcc ccaggagaaa agaggtggaa      660

agtagactga gcccagggga atctgcctac cagaagttgg gcctgacaga ggcccataaa      720

tggagacctg actccagaga gtctcaggaa cagagtttgg tacaactgga ggcaacagag      780

tggaggctga ggtcaggaga agaaagacaa gactactcgg aagaatgtgg gagaaaagaa      840

gagtggccag ttccaggggt agctccaaaa gagactgcag agctgtccga gaccctgaca      900

agggaggccc aaggcaacag ttccgcagga gtggaggcag cagagcagag gcctgtggaa      960

gatggcgaga ggggcatgaa gccaacagaa gggtggaaat ggaccctgat aatgagcctg     1020

gcagggaagg gcaaccaaca tcttgtaact tgctttcccc accctgtttc tgggggcaga     1080

gccaattgcc caatttctac cctaatccaa agtccctggt gtgggtgggg ttaa           1134


<210> 4539
<211> 1029
<212> DNA
<213> Homo sapiens

<400> 4539
gttccagggt cgggtttggt ggattcctca gtccctgccg ccgcggggcg ccctgggata       60

gcggcggggc ctcctgaaca gatctcggcc cctttccaaa cactcctgat gcctcatttg      120

cctctcgctt cttttcgacc accattttgg gggctgaggc actcacgggg cctccccagg      180

tttcactccg tttctacaca gtcggagccc catggatctc ccatctcccg gaggaaccgt      240

gaagccaaac agaagcgcct gcgagagaag caggctactc tggaggctga gatagcaggg      300

gagagcaagt cacctgcaga atccattaag gcctggaggc ctaaggagtt agtattgtat      360

gaaatcccta cgaaacccgg tgaaaagaaa gatgtctctg ggcccctgcc tcctgcatac      420

agcccccgat atgttgaggc tgcctggtac ccgtggtggg tacgagaggg cttcttcaaa      480

ccagaatatc aggcccggct gccccaagct acaggggaga ccttttccat gtgtatccca      540

cctcccaatg tcactggctc cctgcacatt ggccacgcac tcacggtggc catacaggat      600

gccctcgtgc gctggcaccg gatgcgtggg gatcaagtgc tgtgggtccc tggttcagat      660

catgcaggaa ttgctacaca agctgtggtg gagaaacaac tgtggaagga acggggagtg      720

aggagacatg agctgagccg ggaggccttc cttagggagg tgtggcagtg gaaggaggcg      780

aaaggtggag agatctgtga gcagctgcga gctctgggtg cctccctgga ctgggatcga      840

gtgttttacc atggatgttg gctcctcagt ggctgtgact gaagcttttg tgcggctcta      900

caaggcgggg ttgctgtacc ggaaccatca gcttgtcaac tggtcatgtg ctttaagatc      960

agccatctcg gacattgagg tggagaaccg gcccctgcct ggccacacac agcttcgact     1020

gcctggctg                                                             1029


<210> 4540
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 4540
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaatctgc ctaatcacct ggttatcccc acagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct ga                                              1522


<210> 4541
<211> 1716
<212> DNA
<213> Homo sapiens

<400> 4541
gaggtcgagg taagagcgcg gcgttggtgg tttgcatttt ccgcagcgct cgcgaccgcc       60

cgctcggccc cggcctcgcc tcggagcccc gcgagggctg cgcgctcggg ccgattcctc      120

gacagcgccc gcggcggcga gaaccaccgc agccatcctg gtccgggagc gaccgccgcg      180

gcacccccaa ccccgccaga gcgggcacca ggaagcgggg ggaggggagc gaggagcctc      240

ccgggcggag atgcggcagc tcccgcacct ccgcaccccg ggttggtgcc tcggggcccc      300

gcagcgcttt agggcggaga accaagtttg tgtgggtgct tcttcctggg ggccctcggg      360

ctgcgccagg tgtgagaccg gaatgccaat ttggggaatc tctcctgttc tttccttttt      420

aattttttct acttgtcctt gacaagggcc tattcccact ggatctgcag gtgactattt      480

gctcttccta ggtcgccagt ctttgatttc agctagtgac cctgggcggg aagacaccct      540

gttcaccctc ctcctgacct ccgcccccca cctcttcagc caactttatc ttggatctct      600

gctctcttta tcttttctct agagctgggc cagggcgcta actggaagct tggggttaaa      660

tggtgcagga acgtagaggc ggaggagtcc ctgggatttt ccacgtctat ttccccaccc      720

ccaccccagc cgcaggggtc cagtttggac tgacccaacc tcccgctttc tctttgtagg      780

cgatcagtgg gtgaccgcgg ctgcgaggga ctttgtcatc cgtcctccag gatctgggga      840

gaaagagccc catcccttct ctctctgcca ccatttcgga caccccgcag ggactcgttt      900

tgggattcgc actgacttca aggaaggacg cgaacccttc tctgacccca gctcgggcgg      960

ccacctgtct ttgccgcggt gacccttctc tcatgaccct gcggtgcctt gagccctccg     1020

ggaatggcgg ggaagggacg cggagccagt gggggaccgc ggggtcggcg gaggagccat     1080

ccccgcaggc ggcgcgtctg gcgaaggccc tgcgggagct cggtcagaca ggatggtact     1140

ggggaagtat gactgttaat gaagccaaag agaaattaaa agaggcacca gaaggaactt     1200

tcttgattag agatagctcg cattcagact acctactaac aatatctgtt aaaacatcag     1260

ctggaccaac taatcttcga atcgaatacc aagacggaaa attcagattg gactctatca     1320

tatgtgtcaa atccaagctt aaacaatttg acagtgtggt tcatctgatc gactactatg     1380

ttcagatgtg caaggataag cggacaggtc cagaagcccc ccggaacggc actgttcacc     1440

tttatctgac caaaccgctc tacacgtcag caccatctct gcagcatctc tgtaggctca     1500

ccattaacaa atgtaccggt gccatctggg gactgccttt accaacaaga ctaaaagatt     1560

acttggaaga atataaattc caggtataaa tgtttctctt tttttaaaca tgtctcacat     1620

agagtatctc cgaatgcagc tatgtaaaag agaaccaaaa cttgagtgct ctggataact     1680

atatggaatg ctttctaaga acagctgaag ctaatc                               1716


<210> 4542
<211> 577
<212> DNA
<213> Homo sapiens

<400> 4542
aacgaaggct gctgggttca tagggaggag ggcagtttgg ggcccgaggg cgaaagagta       60

ggctcggggt gtctggagat agcacccata agagcggtct tgcaggcgcc gggggcttgt      120

gggcgcgtgg attagggcgg aggtatcagg gatggcagga caggtgcccc gagaactggt      180

tgatctttga tcttagattc tgcctgcctt cttccccgtc tcaattgtag ccatcatgac      240

cacccggcaa gccacgaagg atcccctcct ccggggtgta tctcctaccc ctagcaagat      300

tccggtacgc tctcagaaac gcacgccttt ccccactgtt acatcgtgcg ccgtggacca      360

ggagaaccaa gatccaagga gatgggtgca gaaaccaccg ctcaatattc aacgccccct      420

cgttgattca gcaggcccca ggccgaaagc caggcaccag gcagagacat cacaaagatt      480

ggtggggatc agtcagcctc ggaacccctt ggaagagctc aggcctagcc ctaggggtca      540

aaatgtgggg cctgggcccc ctgcccagac agaggct                               577


<210> 4543
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 4543
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaatctgc ctaatcacct ggttatcccc acagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct ga                                              1522


<210> 4544
<211> 2718
<212> DNA
<213> Homo sapiens

<400> 4544
aaagtaattt tctgaaggga agctgcagaa tatggaaaac atatattgga gctacatgga       60

tcatgtcaag ttcagactgt aaggagtaga tgcagtagtg aagctgtcca tctcaggtga      120

attgaaaaag taaagaacta caaaatgcca tcattccctc tctgtgttga tttctggtga      180

agctcagagg atgagtaaga gatacttaca gaaagcaaca aaaggaaaac tgctaataat      240

aatatttatt gtaaccttgt gggggaaagt tgtatccagt gcaaaccatc ataaagctca      300

ccatgttaaa acgggaactt gtgaggtggt ggcactccac agatgctgta ataagaacaa      360

gatagaagaa cggtcacaaa cagtcaagtg ctcctgcttc cctgggcagg tggcaggcac      420

cacgcgagct gctccatcat gtgtggatgc ttcaatagtg gaacagaaat ggtggtgcca      480

tatgcagcca tgtctagagg gagaagaatg taaagttctt ccggatcgga aaggatggag      540

ctgttcctct gggaataaag tcaaaacaac tagggtaacc cattaaccca ggagaaatca      600

agtgatcctc aaggctgatg acattgaaca tgcgcataga aacttaactc aactcctgag      660

gtgatcttga agatttttat accacttgaa agaggcgctc aatagtctat ttccaaggga      720

tttcatggcc tcttcttgaa atcaagactt tttaaaagtc agacatgaac ttgcatgtca      780

tgaagatttc agcagatttg aactgtgttc aacttgtaaa ttgttaaaag aatttgaagt      840

cactgtctga ggagctggtg aagagttgtt tttttcaggg tgatgttaga gacagtcacc      900

ttttgagtta ttggctccag atgtgactac ttttcttgtt tctgcaagct gtatcccaag      960

tgcactgtcc ttctgtcctg gatgtgttcc tgggtcctat gttcatttgc tagtgggact     1020

acacatggct ttaatgacat ttcctttgag aacttttcct ctggcatggt gtagactgag     1080

acaattttat ttatatccta atcttggagc tcagaaagcc tacatgtttt aacatcttaa     1140

agttgctttt gttaaaggaa tggaaatata tatccattgg taataatgtt ggcaagtaat     1200

agttatctga ataaatcaat catataagaa tgtatagaca agctgacata tttccctaag     1260

gctaacaaca ccctgctgaa gctctttgtc aaataggtag tagttagaac tggattgcca     1320

ttttcattat ataatacttt gtacctctag agcactctcc ctttctgttt ttttttaagt     1380

gagcttttct ttaatttttt atgtttactt attcccttca cagaaatcag cagtgagcag     1440

tcaagttaat gggtagcctt cagtttcaaa aaaattgaca gggatgcatg tgagtttctg     1500

atttcttagc ttgaacatta ttcacttaga tttcttccag tattttttaa aaaactgtcc     1560

tatctcattt taaaagactt tcttttgctt gatcccaatg actgtttgaa tgcttatata     1620

tttgttcaat ctgttgatag aaaaaattgt tcattttcct cagtctcaaa tttataaata     1680

tttgcttaca gttttcctat tcaaacaatt tgttaggcca atattttgtg acatttttgt     1740

agcgatttta acgtttatgg ttttggttct acaggaaagt cataaatatt taaaggcctt     1800

aaacatgtat gtactttttt tttctaagtt atagaatgta taattttgta ctacatttat     1860

tttgtttcat ttgtgatatg aagggagaga agaaagaaaa gtgcatagcc attctgtaac     1920

aatattgtgt aaacctatag tttgaaggaa tgcaaggaga aggatttctg tgttttactc     1980

attttaggct gttcagaaga tgcttcaaaa attgtcctgt tagaatttcc atcatggaag     2040

gtggtatgga agaaggtatg gaaatacttt gtattctaaa aactcactga cgtggtcagt     2100

tagacatacg ttggtttcca ggatagaggc ccatatatcc tggggagctt tggtctatta     2160

gtttgtgaca atattcaaag gccaaaacac tactcagaca ctttcctggg aagagcaact     2220

aaaaatgtaa aattggttaa aaataaaatc tgaaaagtat gtatctcaca ttgaactaaa     2280

atccactgtc tcataagttc atggaatgaa atggctttct gcctccattt taatcatgca     2340

taaaatgaat tagatggctt tgagtggatt ttcacaatgg ctcaagacta tatgaaatta     2400

taaaaaaaaa gttgccctgg ggtttctgca tcaattagaa tatcattaat ttctttgtaa     2460

ccaagtgaaa aactatactt tttggaaatt atgaatttgt cctaggtttg tttgagattt     2520

gaaattatac atcatgcttc tcatttttta aactatgttc tttaaatcaa cactggaaac     2580

tctgtattat atacaagtgt aatacatgca tataatagaa aaaaaacatg gaatttcaaa     2640

tatactaact agattatccc cagtagatta atgttgtgac tattcagaaa aggtgaataa     2700

aattgggata taaaatgg                                                   2718


<210> 4545
<211> 2840
<212> DNA
<213> Homo sapiens

<400> 4545
gagcttcccg gctgctttgt ttacctaagc aagcctgggc aatggcgggc gtccctcccc       60

cagcctcgtt gccgccttgc agtttgatct cagactgctg tgctagcaat cagcgagatt      120

ccgtgggcgt aggaccctct gagccaggtg tgggatatag tctcgtggtg cgccgtttct      180

taagccggtc tgaaaagcgc aatattcgga tgggagtgac ccgattttcc aggaactgaa      240

gttaaaagat gaagaatgtg agaggctttc aaaagtgcga gatcaacttg gacaggaatt      300

ggaagaactc acagctagtc tatttgagga agctcataaa atggtgagag aagcaaatat      360

caagcaggca acagcagaaa aacagctaaa agaagcacaa ggaaaaattg atgtacttca      420

agctgaagta gctgcattga agacacttgt attgtccagt tctccaacat cacctacgca      480

ggagcctttg ccaggtggaa agacaccttt taaaaagggg catacaagaa ataaaagcac      540

aagcagtgct atgagtggca gtcatcagga cctcagtgtg atacagccaa ttgtaaaaga      600

ctgcaaagag gctgacttat ccttgtataa tgaattccga ttgtggaagg atgagcccac      660

aatggacagg acgtgtcctt tcttagacaa aatctaccag gaagatatct ttccatgttt      720

aacattctca aaaagtgagt tggcttcagc tgttctggag gctgtggaaa acaatactct      780

aagcattgaa ccagtgggat tacaacctat ccggtttgtg aaagcttctg cagttgaatg      840

cggaggacca aaaaaatgtg ctctcactgg ccagagtaag tcctgtaaac acagaattaa      900

attaggggac tcaagcaact attattatat ttctcctttt tgcagataca ggatcacttc      960

tgtatgtaac ttttttacat acattcgata cattcagcag ggactcgtga aacagcagga     1020

tgttgatcag atgttttggg aggttatgca gttgagaaaa gagatgtcat tggcaaagct     1080

gggttatttc aaagaggaac tctgatgctc tgcgtgggac catgcctgaa ctccccgaat     1140

aactgaaaaa tggctgaata tttttatggt tacttgatat ttatttccaa ggagtgagcc     1200

taagactttt ttcccctttt gcaaattgct ctaagaagta ccatgatttc ttttaaactg     1260

atctatgctg tgtttgctta ttctttagtt gaacacacta tgaagaattc caggtgtact     1320

agtgaatgta atttatagtt gccaaaaaaa aaaaaaacct gaaataaata aatgttagat     1380

tgaatgtgtg tacattttct cttctagctc tgacatggca tttagggtta gcagaatgta     1440

ttaaatagta attttcaaac tacacagtag cttccttcct tgtgagaggc aagaaagaag     1500

tctgagtgga tagtactcac tttccaaggc ccccacctct agaatggctt tatttttatc     1560

tgttttctat attgggtttc aaaaaagatt ttatttgaag aaatacttct gctgctacaa     1620

agtttgaaag ttactatttt aattattctg ctctctgtaa ctgaaagaat ccctttattt     1680

tggttattca ttaaaatata atagaaggca gtcagatttt atcccagaga tgtattcctg     1740

agtgtcttga tatagtgtat tcatgtttta tatgtgttga ccactatatt gtcattggag     1800

ggacatagat gtaaatgagt ttgacgtgtg tcaaaggggt ttaaaggggt gtggattgaa     1860

tgaatggtac gtgcgaagta tatgctgatt atagaaccac ttgatctctg cattccaaat     1920

tgtaaaactg actcaactgg agaaattata acaaagaggt ttgtggtaga catgtaataa     1980

gtatagaaaa gcaaaaagaa aagagaaact gctttagttt ctgtttagag aaagctgctg     2040

ttaatatttt tggatagtag cctttcagct ttcagatatt ttctacttac atatgcatat     2100

ttttgaaaca aaaagtaggc tttttttttg ctttttaaac ctaaacatta aatatatttt     2160

cccttgggta aacctacaca tcctaatccc tgtttataga attttaacat aatttaattg     2220

tgtttggaga tgaggtggtt ttcagtttat ttttcatatt ataatgctgt gacgagtatc     2280

cttatctgta cacttctgaa cattgtggag ttctttcatg tggatgcctg gagataaaat     2340

tgtgtcgaga tatatatgta tttttaaatg tttgatctgc attgctagat tgccatccag     2400

aaaagttaat caatttgtat tcacagcagc agtgtacaag agggctggtt ttctgaagat     2460

aacatttttt tcagtcctgt tcagaggttt ggtcaatctt acctgtagat gacttcagcc     2520

accaggctgg atgggagccc acagacaaaa ggacattggt gtatgttatg gtgaaaacca     2580

tcagtaccat gcctagctca agaatgtgaa attgaacctg aaaaaaactt tgaacctaca     2640

attttatgtt ctgaaaatag ttattctaat gtgagggcat taataagaat atgtaccatc     2700

aaagcttcag aagattttcc gtacaaacta aaatcacttt tggagaaagt acctaaataa     2760

aaagagaaac aaatccagga gatactgtac ggtttgaaag aaaggtaatc aaatactcag     2820

aaaaagtttg ttgatgactt                                                 2840


<210> 4546
<211> 3377
<212> DNA
<213> Homo sapiens

<400> 4546
gccagctgct gcgcatgcgc cggccggggc cccgccccca tgcgccgcgc ggctccaggg       60

ccacgttcca gggtcgggtt tggtggattc ctcagtccct gccgccgcgg ggcgccctgg      120

gatagcggcg gggcctcctg tcacctgcag aatccattaa ggcctggagg cctaaggagt      180

tagtattgta tgaaatccct acgaaacccg gtgaaaagaa agatgtctct gggcccctgc      240

ctcctgcata cagcccccga tatgttgagg ctgcctggta cccgtggtgg gtacgagagg      300

gcttcttcaa accagaatat caggcccggc tgccccaagc tacaggggag accttttcca      360

tgtgtatccc acctcccaat gtcactggct ccctgcacat tggccacgca ctcacggtgg      420

ccatacagga tgccctcgtg cgctggcacc ggatgcgtgg ggatcaagtg ctgtgggtcc      480

ctggttcaga tcatgcagga attgctacac aagctgtggt ggagaaacaa ctgtggaagg      540

aacggggagt gaggagacat gagctgagcc gggaggcctt ccttagggag gtgtggcagt      600

ggaaggaggc gaaaggtgga gagatctgtg agcagctgcg agctctgggt gcctccctgg      660

actgggatcg agagtgtttt accatggatg ttggctcctc agtggctgtg actgaagctt      720

ttgtgcggct ctacaaggcg gggttgctgt accggaacca tcagcttgtc aactggtcat      780

gtgctttaag atcagccatc tcggacattg aggtggagaa ccggcccctg cctggccaca      840

cacagcttcg actgcctggc tgccccaccc ccgtgtcttt tggcctccta ttttctgttg      900

ccttccccgt ggatggagag cctgatgcag aggttgtggt aggaaccaca aggccagaga      960

cgctgcctgg agatgtggct gtggccgttc atccagacga ctcgcgatac acacatctac     1020

acgggcgaca gcttcgtcac cccttgatgg ggcagcctct tcccctcatc acagactatg     1080

ctgttcagcc acatgtgggc acgggggcag tgaaggtgac tccagctcac agtcctgccg     1140

atgctgagat gggggcccga catggcttga gccccttgaa tgtcattgcg gaggatggga     1200

ccatgacctc cctctgcggg gactggctgc agggtcttca ccggtttgtg gcccgggaaa     1260

agataatgtc tgtgctgagt gaatggggcc tgttccgggg cctccagaac caccccatgg     1320

tactgcccat ctgcagccgt tctggggatg tgatagaata cctgctgaag aaccagtggt     1380

ttgtccgctg ccaggaaatg ggggcccgag ctgccaaggc tgtggagtcg ggggccctgg     1440

agctcagtcc ctccttccac cagaagaact ggcagcactg gttttcccat attggggact     1500

ggtgtgtctc ccggcagctg tggtggggcc atcagattcc agcctacctg gttgtagagg     1560

accatgcgca gggagaagag gactgttggg tggttgggcg gtcagaggct gaggccagag     1620

aggtagcagc ggaactgaca gggaggccag gggcagagct gaccctggag agggatcctg     1680

atgtcctaga cacatggttt tcttctgccc tgttcccctt ttctgccctg ggctggcccc     1740

aagagacccc agaccttgct cgtttctacc ccctgtcact tttggaaacg ggcagcgacc     1800

ttctgctgtt ctgggtgggc cgcatggtca tgttggggac ccagctcaca gggcagctgc     1860

ccttcagcaa ggtgcttctt catcccatgg ttcgggacag gcagggccgg aagatgagca     1920

agtccctggg gaatgtgctg gacccaagag acatcatcag tggggtggag atgcaggtgc     1980

tgcaggaaaa gctgagaagc ggaaatttgg accctgcaga gctggccatt gtggctgcag     2040

cacagaaaaa ggactttcct cacgggatcc ctgagtgtgg gacagatgcc ctgagattca     2100

cactctgctc ccatggagtt caggcgggcg acttgcacct gtcagtctct gaggtccaga     2160

gctgccgaca tttctgcaac aagatctgga atgctcttcg ctttatcctc aatgctttag     2220

gggagaaatt tgtgccacag cctgctgagg agctgtctcc ctcctccccg atggatgcct     2280

ggatcctgag ccgccttgcc ctggctgccc aggagtgtga gcggggcttc ctcacccgag     2340

agctctcgct cgtcactcat gccctgcacc acttctggct tcacaacctc tgtgacgtct     2400

acctggaggc tgtgaagccc gtgctgtggc actcgccccg ccccctgggg ccccctcagg     2460

tcctgttctc ctgcgctgac ctcggcctcc gcctcctggc cccactgatg cccttcctgg     2520

ctgaagagct ctggcagagg ctgcccccca ggcctggttg cccccctgcc cccagcatct     2580

cggttgcccc ctaccccagc gcctgcagct tggagcactg gcgccagcca gagctggagc     2640

ggcgcttctc ccgggtccaa gaggtcgtgc aggtgctaag ggctctccga gccacgtacc     2700

agctcaccaa agcccggccc cgagtgctgc tgcagagctc agagcctggg gaccagggcc     2760

tcttcgaggc cttcttggag cccctgggca ccctgggcta ctgtggggct gtgggcctgt     2820

tacccccagg cgcagcagct ccctccggct gggcccaggc tccactcagt gacacggctc     2880

aagtctacat ggagctgcag ggcctggtgg acccgcagat ccagctacct ctgttagccg     2940

cccgaaggta caagttgcag aagcagcttg acagcctcac agccaggacc ccatcagaag     3000

gggaggcagg gactcagagg caacaaaagc tttcttccct ccagctggaa ttgtcaaaac     3060

tggacaaggc agcctctcac ctccggcagc tgatggatga gcctccagcc ccagggagcc     3120

cggagctcta actcatcatc cccatcagtt ttcctccctc tcagacctgt ctttgaggac     3180

aaacagattt gtcagctgtc agggtgcagt gggacgtcag agactatgtg gtccatcgcc     3240

ttcattgtgt aaatgaggac acagactggc ttggtcgcag tgactgtggt gtccttgaga     3300

tgctcacatt actgcccggc ctgcctccca cctggaagtc tgggaatgag gagattgaga     3360

taaacttttg aaatccc                                                    3377


<210> 4547
<211> 5900
<212> DNA
<213> Homo sapiens

<400> 4547
gcggagtcgg gaatcaaaac aaagggcctg gggggggcgg ggggaaggcg gcggggccgg       60

aatgtgagcg gaggtggagc cggcggcaga gggtggaaga atgaaagaaa agaaagatga      120

aaggatgttg aatcactttg catggctgta tgatggaagg aaacggaact gagaactcct      180

gcagtagaac acgtggatgg cttcaacaag ataatgatgc taagccatgg ctttggaaat      240

tctctaattg cttttctcgt cctgagcaga cgctgccaca tagtccccaa acgaaagagt      300

acatggagaa caagaaagtt gctgtggaac taaaggatgt accatcaccc cttcatgctg      360

gctctaagct ttttccagca gtcccacttc ctgatattcg ttctcttcag cagcctaaaa      420

tacagctttc ttctgtcccc aaagtaagct gctgtgctca ttgccctaat gaaccctcca      480

cttcgccaat gcgttttggt ggtggtggtg gcggtagcgg aggtaccagt agcttgattc      540

acccgggcgc actgttagac tcgcaaagca ccaggacaat cacgtgtcag gtagggtcag      600

ggtttgcttt ccagtctgca tcttcactcc agaatgcctc agctaggaac aatttggcag      660

gcattgcaag tgactttccc agcatgtgtc tagagagtaa cctgtcttcc tgcaaacacc      720

tgccctgttg tggaaaactc cacttccagt catgtcatgg taatgtgcac aagctgcatc      780

agtttccgag tctgcagggc tgcacctccg ctggctattt cccctgttct gatttcacaa      840

gcggggctcc agggcatttg gaagagcaca tttcacagtc ggagctaacg cctcacttgt      900

gcaccaactc tttgcacctt aatgtggtac ctccggtttg tttaaagggc tcactttact      960

gcgaagactg tctaaacaag ccagcaagaa atagcataat cgatgcggct aaagtctggc     1020

caaatatacc acctccaaat actcaacctg cacctcttgc tgtccctctg tgtaatggct     1080

gtggaaccaa aggaacaggg aaggagacca cgttgttatt ggcgaccagt ctaggcaaag     1140

ctgcttcaaa atttgggtca ccagaagttg cagtagctgg acaggtgcta gaaaacttac     1200

cccccattgg agttttttgg gatattgaaa actgctccgt tccctctggc cggtcagcaa     1260

ctgctgttgt gcaaagaatc cgtgagaagt tttttaaagg ccacagagaa gcagaattca     1320

tctgtgtatg tgacatcagt aaagaaaaca aggaagttat tcaagagctg aataattgcc     1380

aggtaaccgt tgcccacatc aatgctactg caaagaatgc cgctgatgat aaactgcggc     1440

agagtctccg cagatttgca aatacacaca ctgctccagc cacagtggtt cttgtgtcaa     1500

ctgatgtcaa ttttgcattg gaacttagtg acctgagaca caggcatggt ttccacatta     1560

ttttggtcca taaaaaccag gcctcagaag cactgctgca tcatgctaac gagctgatca     1620

gatttgaaga gttcatttcc gacttgcccc ccaggttacc actaaaaatg ccatgccaca     1680

ctctgctcta tgtttataac ctaccagcaa ataaggatgg caagagcgtc agcaacaggc     1740

tcagacgcct gtccgataat tgtggtggga aagtgctgag tatcacaggc tgcagtgcaa     1800

ttctccgctt cataaaccaa gatagtgcag agcgcgctca gaagcgaatg gaaaacgaag     1860

atgtctttgg taataggatc attgtgtcat ttactccaaa aaatagagaa ctctgtgaaa     1920

caaagagttc aaatgcaatt gctgataaag tgaagtctcc caaaaaactt aagaatccaa     1980

aattgtgcct catcaaagat gcaagtgaac aatcttccag tgccaaagcc acgcctggaa     2040

aagggtcaca ggcaaattct ggatctgcta caaaaaatac aaatgttaaa agtttacagg     2100

agctgtgccg catggagtca aaaactggtc atagaaacag tgagcaccag caaggtcacc     2160

tgaggctggt cgtacccact cacggtaact caagtgctgc agtgtcgacg ccgaaaaact     2220

cgggggtggc agaacccgtt tacaaaacca gtcagaaaaa ggagaacctc agtgcccgaa     2280

gtgttaccag ttctcctgta gagaaaaaag ataaagagga gactgtattc caagtgagtt     2340

acccgtctgc ttttagcaag ttagttgcat ccaggcaagt cagtcctctg ctcgcatctc     2400

agtcttggtc ttctagcagg agtatgtctc caaacctttt aaacagagca tccccgcttg     2460

ctttcaacat tgcaaattcg agcagcgaag ccgactgccc agacccattt gcaaatggtg     2520

ctgatgtcca agtcagcaac atagactaca gattatcccg gaaggagctg cagcagctcc     2580

tgcaggaagc atttgccagg catggcaagg tgaagagtgt tgagctcagc ccccatacag     2640

attatcaact caaggctgtt gtgcaaatgg aaaacttaca agatgcgatc ggtgcagtga     2700

atagcctcca cagatacaaa attggcagca aaaagatcct ggtctcactt gccaccgggg     2760

ctgccagcaa atcactctct ttactgagtg cagaaacaat gtctgttctt caggatgccc     2820

ctgcctgttg cctgcctctg tttaaattta cagatatcta tgaaaaaaag tttggacaca     2880

agttgaatgt gtcagatcta tataaattaa cagacacggt cgcaatccgt gaacaaggaa     2940

acggacggct ggtgtgtctc ctacccagca gtcaggcccg ccagagcccc ttggggtctt     3000

cccagtcaca cgacggctcc tccacgaatt gcagcccaat tatatttgaa gagttagaat     3060

atcacgagcc tgtctgcaga cagcattgtt ccaataagga tttcagcgaa catgaatttg     3120

atccagactc ttacaagatt ccttttgtga ttctttcttt gaagacattt gcgccccagg     3180

ttcacagtct tctccagacc cacgagggca ccgtgccttt attgagcttt ccagattgtt     3240

acattgcaga gtttggcgat ctagaagtag tgcaagaaaa ccaaggaggt gttcccttag     3300

aacacttcat tacctgtgtt ccaggtgtaa acattgccac tgctcagaat ggcatcaaag     3360

tggttaaatg gattcacaac aagcccccgc ctcccaacac tgacccttgg cttctgcgtt     3420

cgaagagtcc tgtaggtaac ccccagctga tccagttcag tagagaagtg attgacttgc     3480

tgaaaagcca gccatcttgt gtcataccca tcagtcattt catcccatcc tatcaccatc     3540

attttgcaaa gcagtgccga gtgtcagact acggatactc caagctgatt gagttattag     3600

aagcagtgcc tcatgtattg cagattcttg gaatgggctc caaacgtctg ctgaccctta     3660

cccacagggc ccaggtgaag cgctttactc aggatttact aaaacttctc aaatcccagg     3720

ccagcaaaca ggtcattgtg agagaattct cacaggctta tcactggtgt ttctcaaagg     3780

actgggatgt cactgaatat ggtgtttgtg agttgattga catcgtatca gagattccag     3840

acacaaccat ctgcttgtcc caacaagata atgaaatggt gatttgtatc cccaaaagag     3900

aacgcactca ggatgaaata gaaaggacaa aacagttctc caaggatgtc gttgatttgc     3960

tgcgtcacca accccatttc cggatgccct ttaataaatt tatcccttct taccatcacc     4020

actttggccg gcagtgcaaa cttgcgtact atgggtttac caaactactt gaactttttg     4080

aagccatacc tgatacttta caagtattgg aatgtggaga agaaaagatc cttactctga     4140

cagaggtgga gcggttcaaa gctctagctg cccagtttgt taaactcctt cggtcccaaa     4200

aagataactg ccttatgatg acagatctcc ttacagaata tgctaaaact tttggttata     4260

catttcgtct ccaagactat gatgtcagtt ccatttcggc tttaactcag aaactctgcc     4320

atgtcgtgaa ggttgccgat atagaatctg gcagacagat tcagctgatc aaccgaaagt     4380

ctctgcgatc tctcactgcc cagttgctgg tattgttgat gtcttgggaa ggaaccaccc     4440

atctttctgt tgaggagctc aagagacatt acgaaagtac ccacaacact ccccttaacc     4500

cctgtgaata tggattcatg accttgaccg aactgctgaa gagcctgcca tacttggttg     4560

aggttttcac taatgataag atggaagaat gtgtgaagct cacaagtctg tatttgtttg     4620

caaagaatgt gcggtcttta cttcatactt accactacca gcagattttc cttcatgagt     4680

tttccatggc ctataccaag tatgtcggag aaactctgca gcccaagacc tacggccaca     4740

gcagcgtgga ggagctcttg ggagcaattc cacaggtggt ctggataaaa ggacatggtc     4800

ataagagaat tgtagtgtta aaaaatgaca tgaaaagtcg tttgagttca ctcagtctct     4860

cccctgccaa tcatgaaaac cagccctcgg agggcgagcg catcctggag gtgcccgaat     4920

cgcacacagc ctcggaactc aagcttggag ctgacggcag tgggcccagt cacacagagc     4980

aggagcttct ccgcctgacc gacgactccc ccgtcgacct cctgtgtgcg cctgtcccct     5040

cgtgcctgcc gtcccctcag ctgagaccag accccgttat cctccaatct gctgatctca     5100

ttcagtttga ggagcgccct caagagcctt ctgaaattat gattttaaac caagaagaaa     5160

aaatggagat tccaatacca ggaaagagca aaactctgac ctctgactcc agctcgtcct     5220

gcatctcagc agctgtcccc gtgcctccct gcccctcctc ggaaacctcc gagtcactgc     5280

tcagcaagga ccccgtggaa agcccggcca aaaagcaacc caaaaataga gtcaaattgg     5340

cagccaactt ttccttagca cctataacca agctttaact cccatttgga atatagaatt     5400

aggatgggaa aacactgtct gattctgcac acaaaagtgg gtttcaaaaa tacatccttt     5460

tctgtgtcat gaaaaccccc cgaagccatt gacttcatct tacctgtgtt ctatcatgtt     5520

tttcttttcc attgaacaca gctttgagct gaagtctttc ttttcttctt cctttttctt     5580

tcttttttca attatttgaa gaacttgtgg catttgttaa agaatcctta atatatttta     5640

ccaaattttt agtaactatt atgaaataca atggtgttcc aaaagaagaa agcactaaaa     5700

actcaactag caggaagcgg ttttgcttcc attgagccac gtcggtggtg tcatcctaca     5760

tgtagcataa tagagtctct cagcctttgc ttactggtgt ttccgacagt attaacccag     5820

tgcgtggcat gtctttgaag caaagcctgt cccgctagcc tgtgtgttca cacaccaaag     5880

gagaagggta ggcgaggggt                                                 5900


<210> 4548
<211> 1029
<212> DNA
<213> Homo sapiens

<400> 4548
gttccagggt cgggtttggt ggattcctca gtccctgccg ccgcggggcg ccctgggata       60

gcggcggggc ctcctgaaca gatctcggcc cctttccaaa cactcctgat gcctcatttg      120

cctctcgcct cttttcgacc accattttgg gggctgaggc actcacgggg cctccccagg      180

tttcactccg tttctacaca gtcggagccc catggatctc ccatctcccg gaggaaccgt      240

gaagccaaac agaagcgcct gcgagagaag caggcgactc tggaggctga gatagcaggg      300

gagagcaagt cacctgcaga atccattaag gcctggaggc ctaaggagtt agtattgtat      360

gaaatcccta cgaaacccgg tgaaaagaaa gatgtctctg ggcccctgcc tcctgcatac      420

agcccccgat atgttgaggc tgcctggtac ccgtggtggg tacgagaggg cttcttcaaa      480

ccagaatatc aggcccggct gccccaagct acaggggaga ccttttccat gtgtatccca      540

cctcccaatg tcactggctc cctgcacatt ggccacgcac tcacggtggc catacaggat      600

gccctcgtgc gctggcaccg gatgcgtggg gatcaagtgc tgtgggtccc tggttcagat      660

catgcaggaa ttgctacaca agctgtggtg gagaaacaac tgtggaagga acggggagtg      720

aggagacatg agctgagccg ggaggccttc cttagggagg tgtggcagtg gaaggaggcg      780

aaaggtggag agatctgtga gcagctgcga gctctgggtg cctccctgga ctgggatcga      840

gtgttttacc atggatgttg gctcctcagt ggctgtgact gaagcttttg tgcggctcta      900

caaggcgggg ttgctgtacc ggaaccatca gcttgtcaac tggtcatgtg ctttaagatc      960

agccatctcg gacattgagg tggagaaccg gcccctgcct ggccacacac agcttcgact     1020

gcctggctg                                                             1029


<210> 4549
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 4549
atggccacca tcccagactg gaagctacag ctgctagccc ggcgccggca ggaggaggcg       60

tccgttcgag gccgagagaa agcagaacgg gagcgcctgt cccagatgcc agcctggaaa      120

cgagggctcc tggagcgccg ccgggccaag cttgggctgt cccctgggga gcctagccct      180

gtgctaggga ctgtagaggc tggacctcca gacccggatg agtctgcggt ccttctggag      240

gccatcgggc cagtgcacca gaaccgattc atccggcagg agcggcagca gcagcagcag      300

caacaacaac ggagtgaaga gctgctagca gagagaaagc ctgggcctct ggaggcccgg      360

gagcggagac ccagccctgg ggagatgcgg gatcagagcc ccaagggaag agagtcaaga      420

gaagagagac taagtccgag ggagaccaga gagaggaggc tggggatagg gggagcccaa      480

gagttgagcc tgaggcctct ggaggctcgg gactggaggc aaagcccagg agaggtggga      540

gacaggagct cccgactgtc agaggcatgg aaatggaggc tgagtcctgg agaaactcca      600

gagcggagtc tgagactagc agagtctcga gagcaaagcc ccaggagaaa agaggtggaa      660

agtagactga gcccagggga atctgcctac cagaagttgg gcctgacaga ggcccataaa      720

tggagacctg actccagaga gtctcaggaa cagagtttgg tacaactgga ggcaacagag      780

tggaggctga ggtcaggaga agaaagacaa gactactcgg aagaatgtgg gagaaaagaa      840

gagtggccag ttccaggggt agctccaaaa gagactgcag agctgtccga gaccctgaca      900

agggaggccc aaggcaacag ttccgcagga gtggaggcag cagagcagag gcctgtggaa      960

gatggcgaga ggggcatgaa gccaacagaa gggtggaaat ggaccctgat aatgagcctg     1020

gcagggaagg gcaaccaaca tcttgtaact tgctttcccc accctgtttc tgggggcaga     1080

gccaattgcc caatttctac cctaatccaa agtccctggt gtgggtgggg ttaa           1134


<210> 4550
<211> 776
<212> DNA
<213> Homo sapiens

<400> 4550
gcgttctcct ccgtcctctc tcggttcccc ttgattcctg cggggtccag ggacccggac       60

agcttgggga cgtccgcaga gcctgggttc gagttcttta cccttatcat gaagttttcc      120

ctcatcccca gctccacttg ctgggcagag ttgttcttgc ggaggctggc aacgcgtcag      180

tcgcaggtgg ctttttctca agtatatttt ccagtctgtt tggaactcgg gaaatgagaa      240

ttttaatttt gggattagat ggagcaggaa aaaccacaat tttgtacaga ttacaagtgg      300

gagaagttgt tactactata cctaccattg gatttaatgt agagacggtg acgtacaaaa      360

accttaaatt ccaagtctgg gatttaggag gacagacaag tatcaggcca tactggagat      420

gttactattc aaacacagat gcagtcattt atgtagtaga cagttgtgac cgagaccgaa      480

ttggcatttc caaatcagag ttagttgcca tgttggagga agaagagctg agaaaagcca      540

ttttagtggt gtttgcaaat aaacaggaca tggaacaggc catgacttcc tcagagatgg      600

caaattcact tgggttacct gccttgaagg accgaaaatg gcagatattc aaaacgtcag      660

caaccaaagg caccggcctt gatgaggcaa tggaatggtt agttgaaaca ttaaaaagca      720

gacagtaatt cagtccattc ttctcccctg aaatgaagac tacatcacct ctctcc          776


<210> 4551
<211> 539
<212> DNA
<213> Homo sapiens

<400> 4551
aaactggcaa aattattata ttaatcaata ggcttgactt gaagaaccac attttcttgt       60

tggtcagtca cttgctaatg aactgacatg ctctttccta tttgttttct gctccaagtg      120

attggagggg ctgttatatt caaagaaaga tggatactat gatgctgaat gtgcggaatc      180

tgtttgagca gcttgtgcgc cgggtggaga ttctcagtga aggaaatgaa gtccaattta      240

tccagttggc gaaggacttt gaggatttcc gtaaaaagtg gcagaggact gaccatgagc      300

tggggaaata caaggatctt ttgatgaaag cagagactga gcgaagtgct ctggatgtta      360

agctgaagca tgcacgtaat caggtggatg tagagatcaa acggagacag agagctgagg      420

ctgactgcga aaagctggaa cgacagattc agctgattcg agagatgctc atgtgtgaca      480

catctggcag cattcaacta agcgaggagc aaaaatcagc tctggctttt ctcaacaga       539


<210> 4552
<211> 530
<212> DNA
<213> Homo sapiens

<400> 4552
aaaccggagc tgtgggcgcg gcgctgctct gccgttgggt gaggcgcgga gcgaagtgaa       60

gggtggccca ggtggggcca ggctgactga atgtatctcc tagctatgga ctaaataata      120

catgggggga aataaacaag tattcatgag ggtgaaaatg tgacccagca ggaaaattac      180

aactattttc aattgacgtt gaataggatg gatactatga tgctgaatgt gcggaatctg      240

tttgagcagc ttgtgcgccg ggtggagatt ctcagtgaag gaaatgaagt ccaatttatc      300

cagttggcga aggactttga ggatttccgt aaaaagtggc agaggactga ccatgagctg      360

gggaaataca aggatctttt gatgaaagca gagactgagc gaagtgctct ggatgttaag      420

ctgaagcatg cacgtaatca ggtggatgta gagatcaaac ggagacagag agctgaggct      480

gactgcgaaa agctggaacg acagattcag ctgattcgag agatgctcat                 530


<210> 4553
<211> 932
<212> DNA
<213> Homo sapiens

<400> 4553
gaggcgcgga gcgaagtgaa gggtggccca ggtggggcca ggctgactga aatggatact       60

atgatgctga atgtgcggaa tctgtttgag cagcttgtgc gccgggtgga gattctcagt      120

gaaggaaatg aagtccaatt tatccagttg gcgaaggact ttgaggattt ccgtaaaaag      180

tggcagagga ctgaccatga gctggggaaa tacaaggatc ttttgatgaa agcagagact      240

gagcgaagtg ctctggatgt taagctgaag catgcacgta atcaggtgga tgtagagatc      300

aaacggagac agagagctga ggctgactgc gaaaagctgg aacgacagat tcagctgatt      360

cgagagatgc tcatgtgtga cacatctggc agcattcaac taagcgagga gcaaaaatca      420

gctctggctt ttctcaacag aggccaacca tccagcagca atgctgggaa caaaagacta      480

tcaaccattg atgaatctgg ttccatttta tcagatatca gctttgacaa gactgatgaa      540

tcactggatt gggactcttc tttggtgaag actttcaaac tgaagaagag agaaaagagg      600

cgctctacta gccgacagtt tgttgatggt ccccctggac ctgtaaagaa aactcgttcc      660

attggctctg cagtagacca ggggaatgaa tccatagttg caaaaactac agtgactgtt      720

cccaatgatg gcgggcccat cgaagctgtg tccactattg agactgtgcc atattggacc      780

aggagccgaa ggaaaacagg tactttacaa ccttggaaca gtgactccac cctgaacagc      840

aggcagctgg agccaagaac tgagacagac agtgtgggca cgccacagag taatggaggg      900

atgcgcctgc atgactttgt ttctaagacg gt                                    932


<210> 4554
<211> 1621
<212> DNA
<213> Homo sapiens

<400> 4554
aattttcaga agtttcgtat ggggatggtt ttatataaat tcaggttttt cccacaataa       60

taaatgtatt tagtctcagt gctcaataga agagatttct aatagaaaag gattcaaact      120

gtgaaaccat ttctctttta atgtttcaca ttcctgttac agatttgttc tcttgtgact      180

ctgttatcca taatatggac agttcttgag tcctaacatt gagaggtttt cccttagtgc      240

atagagggaa tgagtattaa ttggagaagc ttaaagtatt gccactttag cactgaagat      300

tgggatgaga ggaggtgaaa cctcactaga aaaagggaca atgttagtgt ggcccttcct      360

gatcatgttt aagaaaagtc atgaaaatgg tgaactagtg tttccaagca tattggaagg      420

gttgagtgta tactgtctgt caaagacttc cagcatttcc aggtcctaga gaggaacaag      480

actggtaacc tgcctatctg tatttttaag aacccaggag gaaagcttta taatagaaca      540

ttatttctgt gtttatgtat aaggggtttt ttgttttttt aaagacagga tctcactcca      600

ttgtccaggc caagtgcaat ggcacgaacc tcatagctcc tggacttaag tgatctgcct      660

gcctttgcct cctgagtagc tgggactaca ggcatgagcc cccatgcctg gctaagtttg      720

tttttttgtt tgtttgtttg tttgtttttg ggggggggtt gttttgtttt ttgtagagac      780

gtagtcttgc tttgttgcca ggctagtctc aaactcctgg cttcaagtga tcctcctgcc      840

tcagcctccc agagtgctag gattacagca cttggattca gcttcttcat ttccaacatg      900

gaagaaactt acaccgactc cctggaccct gagaagctat tgcaatgccc ctatgacaaa      960

aaccatcaaa tcagggcttg caggtttcct tatcatctta tcaagtgcag aaagaatcat     1020

cctgatgttg caagcaaatt ggctacttgt cccttcaatg ctcgccacca ggttcctcga     1080

gctgaaatta gtcatcatat ctcaagctgt gatgacagaa gttgtattga gcaagatgtt     1140

gtcaaccaaa ccaggagcct tagacaagag actctggctg agagcacttg gcagtgccct     1200

ccttgcgatg aagactggga taaagatttg tgggagcaga ccagcacccc atttgtctgg     1260

ggcacaactc actactctga caacaacagc cctgcgagca acatagttac agaacataag     1320

aataacctgg cttcaggcat gcgagttccc aaatctctgc cgtatgttct gccatggaaa     1380

aacaatggaa atgcacagta actgaatacc tatctcatca aatgccagac cctagaagac     1440

tgttgcttct tcttctacca gtgggttctc attttcctcc taatctaatt atagaatggt     1500

aaactccctg tgactttcca aactgacaag cacacttttt tcctcccccc ttgaatcctc     1560

atttaatgca agaaccctca tactcagaag cttccaaata aacctttgat acagattgct     1620

t                                                                     1621


<210> 4555
<211> 1898
<212> DNA
<213> Homo sapiens

<400> 4555
ctccgctgag ctttcgccag tgcctgcggc cctcggcggc ctagtacaca cgcacctgag       60

tgagtggcac cagaggaccc tctccatgtt tagggacctc ctgggcctca ggagcgtggc      120

gcccgcccct gggcggactc cccccatccg cgggcgcgaa tggtccgggc cgcgtccgca      180

gtgctgctgg ctgctccctg gttgctgggt gcaaagtgct gggttctggg tttctggatt      240

cgcgggccgt tcacacgtag cctgtgccgg ctcctcgggt gagtccgtcc gcgcgcggtg      300

ccccgggacg gcctaggctg ccgggggtcc ggggccccag gcattccggg ctgcagattg      360

acggggatcc cggatgcacc gcgcgccccc gcgccctcac cgacgggtcc agacctggtg      420

ggaagaaggt gcggggacgg gtccctgagg atcccgatgc ctacgagcca agatgctcag      480

ggagcctcgg aagcagggcc tggccggcag agcacacctg ctgtcaccag ggaccacagg      540

cagcatgaag acccccgtgg agctggccgt cagtgggatg cagaccctcg gccttcagca      600

ccgctgccga ggtggctacc gggtcaaggc caggacgtca tatgtggatg agactctgtt      660

tggcagccca gcaggcaccc ggcctacccc accggacttc gatccgccct gggtggagaa      720

ggctaacaga accagaggcg tgggcaagga ggcatcgaag gccttggggg caaaggggag      780

ctgtgagacc accccctcaa ggggcagcac ccccaccctc acaccaagga agaagaacaa      840

atacagaccc atcagccaca ccccgtctta ctgtgatgag tcgctgtttg gctcccgatc      900

tgaaggcgcc agcttcgggg ccccgcggat ggcgaagggg gatgccgcaa agctccgtgc      960

tctcttgtgg acgccaccac ctacccccag gggtagccac tcgccccgcc ccagggaggc     1020

accactgcga gccattcacc cagctggtcc ctccaagaca gagccggggc cagcggcaga     1080

ctcccagaag ttatctatgg gtgggttaca ctcttcacgc cccctgaagc ggggactttc     1140

ccattccctc acccacctga atgtccccag cactggtcat ccagccacca gtgcccccca     1200

cacaaatggg cctcaggatc tcaggccttc cacgtcaggg gtgaccttcc ggagccccct     1260

ggtgacttcc agggctcgct cagttagcat ttcagtgcca tctaccccac gacgaggtgg     1320

ggccacccag aaaccaaagc ccccttggaa atgatactct ttcatcaggg ttgcctatgg     1380

ggccacggcg acaggtatgg ccccttgcca gggtaggagg acattcatca cccagggaac     1440

cccaggtatt aaagaagccc ctgtgggggc agacagacat agcaggggtg ggcagtgcct     1500

ccctttatcc tgacaatctc tagtcgattc ttgccttttt ctcccgattg cggatttggg     1560

ggccacctct aagatgcctc tctccagccc tgtctcaacc atactccaaa ttagtgccaa     1620

cccaggggcc tggcacctcc cacatcatcc attgtcttgc tgccaagtgc gaataaacgg     1680

cgtgattgcc aacctggagg gtcccctctt atcccttcaa gccaagcttc ctgctcagga     1740

ttagtttcca gctaagtctg caagccctag aggagttttt ccaggctgtc tgtgaagcct     1800

ggggaacaca acggcaactg ggagatttgt gagtgaacac tgtttcatct taatatgctt     1860

ctgaatttat tttcatgtac taaatagatc agctcatc                             1898


<210> 4556
<211> 3609
<212> DNA
<213> Homo sapiens

<400> 4556
ggcggggcct cctggtgagc gcgcgccggg gcggcctccg ggaagtggga gacgctgcgg       60

gtcctgggcc caggccttgg gatgggcggg aaggcctggc cgcgccgggc tgtgggcact      120

gcaggaggcc cctgtgcaga acagatctcg gcccctttcc aaacactcct gatgcctcat      180

ttgcctctcg cttcttttcg accaccattt tgggggctga ggcactcacg gggcctcccc      240

aggtttcact ccgtttctac acagtcggag ccccatggat ctcccatctc ccggaggaac      300

cgtgaagcca aacagaagcg cctgcgagag aagcaggcta ctctggaggc tgagatagca      360

ggggagagca agtcacctgc agaatccatt aaggcctgga ggcctaagga gttagtattg      420

tatgaaatcc ctacgaaacc cggtgaaaag aaagatgtct ctgggcccct gcctcctgca      480

tacagccccc gatatgttga ggctgcctgg tacccgtggt gggtacgaga gggcttcttc      540

aaaccagaat atcaggcccg gctgccccaa gctacagggg agaccttttc catgtgtatc      600

ccacctccca atgtcactgg ctccctgcac attggccacg cactcacggt ggccatacag      660

gatgccctcg tgcgctggca ccggatgcgt ggggatcaag tgctgtgggt ccctggttca      720

gatcatgcag gaattgctac acaagctgtg gtggagaaac aactgtggaa ggaacgggga      780

gtgaggagac atgagctgag ccgggaggcc ttccttaggg aggtgtggca gtggaaggag      840

gcgaaaggtg gagagatctg tgagcagctg cgagctctgg gtgcctccct ggactgggat      900

cgagagtgtt ttaccatgga tgttggctcc tcagtggctg tgactgaagc ttttgtgcgg      960

ctctacaagg cggggttgct gtaccggaac catcagcttg tcaactggtc atgtgcttta     1020

agatcagcca tctcggacat tgaggtggag aaccggcccc tgcctggcca cacacagctt     1080

cgactgcctg gctgccccac ccccgtgtct tttggcctcc tattttctgt tgccttcccc     1140

gtggatggag agcctgatgc agaggttgtg gtaggaacca caaggccaga gacgctgcct     1200

ggagatgtgg ctgtggccgt tcatccagac gactcgcgat acacacatct acacgggcga     1260

cagcttcgtc accccttgat ggggcagcct cttcccctca tcacagacta tgctgttcag     1320

ccacatgtgg gcacgggggc agtgaaggtg actccagctc acagtcctgc cgatgctgag     1380

atgggggccc gacatggctt gagccccttg aatgtcattg cggaggatgg gaccatgacc     1440

tccctctgcg gggactggtt gcagggtctt caccggtttg tggcccggga aaagataatg     1500

tctgtgctga gtgaacgggg cctattccgg ggcctccaga accaccccat ggtactgccc     1560

atctgcagcc gttctgggga tgtgatagaa tacctgctga agaaccagtg gtttgtccgc     1620

tgccaggaaa tgggggcccg agctgccaag gctgtggagt cgggggccct ggagctcagt     1680

ccctccttcc accagaagaa ctggcagcac tggttttccc atattgggga ctggtgtgtc     1740

tcccggcagc tgtggtgggg ccatcagatt ccagcctacc tggttgtaga ggaccatgcg     1800

cagggagaag aggactgttg ggtggttggg cggtcagagg ctgaggccag agaggtagca     1860

gcggaactga cagggaggcc aggggcagag ctgaccctgg agagggatcc tgatgtccta     1920

gacacatggt tttcttctgc cctgttcccc ttttctgccc tgggctggcc ccaagagacc     1980

ccagaccttg ctcgtttcta ccccctgtca cttttggaaa cgggcagcga ccttctgctg     2040

ttctgggtgg gccgcatggt catgttgggg acccagctca cagggcagct gcccttcagc     2100

aaggtgcttc ttcatcccat ggttcgggac aggcagggcc ggaagatgag caagtccctg     2160

gggaatgtgc tggacccaag agacatcatc agtggggtgg agatgcagtt gctgcaggaa     2220

aagctgagaa gcggaaattt ggaccctgca gagctggcca ttgtggctgc agcacagaaa     2280

aaggactttc ctcacgggat ccctgagtgt gggacagatg ccctgagatt cacactctgc     2340

tcccatggag ttcaggcggg cgacttgcac ctgtcagtct ctgaggtcca gagctgccga     2400

catttctgca acaagatctg gaatgctctt cgctttatcc tcaatgcttt aggggagaaa     2460

tttgtgccac agcctgctga ggagctgtct ccctcctccc cgatggatgc ctggatcctg     2520

agccgccttg ccctggctgc ccaggagtgt gagcggggct tcctcacccg agagctctcg     2580

ctcgtcactc atgccctgca ccacttctgg cttcacaacc tctgtgacgt ctacctggag     2640

gctgtgaagc ccgtgctgtg gcactcgccc cgccccctgg ggccccctca ggtcctgttc     2700

tcctgcgctg acctcggcct ccgcctcctg gccccactga tgcccttcct ggctgaagag     2760

ctctggcaga ggctgccccc caggcctggt tgcccccctg cccccagcat ctcggttgcc     2820

ccctacccta gcgcctgcag cttggagcac tggcgccagc cagagctgga gcggcgcttc     2880

tcccgggtcc aagaggtcgt gcaggtgcta agggctctcc gagccacgta ccagctcacc     2940

aaagcccggc cccgagtgct gctgcagagc tcagagcctg gggaccaggg cctcttcgag     3000

gccttcttgg agcccctggg caccctgggc tactgtgggg ctgtgggcct gttaccccca     3060

ggcacagcag ctccctccgg ctgggcccag gctccactca gtgacacggc tcaagtctac     3120

atggagctgc agggcctggt ggacccgcag atccagctac ctctgttagc cgcccgaagg     3180

tacaagttgc agaagcagct tgatagcctc acagccagga ccccatcaga aggggaggca     3240

gggactcaga ggcaacaaaa gctttcttcc ctccagctgg aattgtcaaa actggacaag     3300

gcagcctctc acctccggca gctgatggat gagcctccag ccccagggag cccggagctc     3360

taactcatca tccccatcag ttttcctccc tctcagacct gtctttgagg acaaacagat     3420

ttgtcagctg tcagggtgca gtgggacgtc agagactatg tggtccatcg ccttcattgt     3480

gtaaatgagg acacagactg gcttggtcgc agtgactgtg gtgtccttga gatgctcaca     3540

ttactgcccg gcctgcctcc cacctggaag tctgggaatg aggagattga gataaacttt     3600

tgaaatccc                                                             3609


<210> 4557
<211> 675
<212> DNA
<213> Homo sapiens

<400> 4557
agttgcatct tgggaattac tgaataatct agtgactaat tttgaatttt aggactgaaa       60

aattttttct cctttctgcc tccctcccat ccccaaatta gctttctaaa aaggaagatt      120

agtgtgtttg agatgtcagc cttgcttttg tgagctgatg gatgctctga agggacaagc      180

tcaatttgtt taagggaaat gtaccaagtc actgaaaatg tggtgaaagg tgcctaagca      240

agcctttttt gtgtgctgct aagagactgg gcaagatgct cagagcacag aaaactcata      300

ttttagtggc ttttcttttt tcatttttat aaagacgctt attcaccttg gagaaaaagg      360

gacctggtgg ccttagtctt tcaggtggaa cggtgtgcga catgggaaag aaaaccaagc      420

ggacagctga cagttcttct tcagaggatg aggaggagta tgttgtggag aaggtgctag      480

acaggcgcgt ggttaaggga caagtggaat atctactgaa gtggaaaggc ttttctgagg      540

agcacaatac ttgggaacct gagaaaaact tggattgccc tgagctaatt tctgaattta      600

tgaaaaagta taagaagatg aaggagggtg aaaataataa acccagggag aagtcagaaa      660

gtaacaagag gaaat                                                       675


<210> 4558
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4558
attactactg aaggaagaac gtgagtaggc cagatcagaa aagggagctc aggtaccttc       60

cagagagtga gacccagcgc ccttgtctcg cacccagtag gctttcatcc ccgccatggc      120

ggagctgatc cagaagaagc tacagggaga agtggagaaa tatcaacagc tacagaagga      180

cttaagtaaa tccatgtcgg ggaggcagaa acttgaagca caactaacag aaaataatat      240

cgtgaaagag gaactggccc tgctggatgg gtccaacgtg gtctttaaac ttctgggtcc      300

ggtgctagtc aaacaggagc tgggggaggc tcgggccaca gtagggaaga ggctggacta      360

tatcacagct gaaattaagc gatacgaatc ccagcttcgg gatcttgagc ggcagtcaga      420

gcaacagagg gagacccttg ctcagctgca gcaggagttc cagcgggccc aggcagcaaa      480

ggcaggggct cctggcaagg cctgacccca tggtgggggg aggggagggg aggggaggga      540

atgaggcagc tctaggatct atactgtagc taataaaatg t                          581


<210> 4559
<211> 1134
<212> DNA
<213> Homo sapiens

<400> 4559
atggccacca tcccagactg gaagctacag ctgctagccc ggcgccggca ggaggaggcg       60

tccgttcgag gccgagagaa agcagaacgg gagcgcctgt cccagatgcc agcctggaaa      120

cgagggctcc tggagcgccg ccgggccaag cttgggctgt cccctgggga gcctagccct      180

gtgctaggga ctgtagaggc tggacctcca gacccggatg agtctgcggt ccttctggag      240

gccatcgggc cagtgcacca gaaccgattc atccggcagg agcggcagca gcagcagcag      300

caacaacaac ggagtgaaga gctgctagca gagagaaagc ctgggcctct ggaggcccgg      360

gagcggagac ccagccctgg ggagatgcgg gatcagagcc ccaagggaag agagtcaaga      420

gaagagagac taagtccgag ggagaccaga gagaggaggc tggggatagg gggagcccaa      480

gagttgagcc tgaggcctct ggaggctcgg gactggaggc aaagcccagg agaggtggga      540

gacaggagct cccgactgtc agaggcatgg aaatggaggc tgagtcctgg agaaactcca      600

gagcggagtc tgagactagc agagtctcga gagcaaagcc ccaggagaaa agaggtggaa      660

agtagactga gcccagggga atctgcctac cagaagttgg gcctgacaga ggcccataaa      720

tggagacctg actccagaga gtctcaggaa cagagtttgg tacaactgga ggcaacagag      780

tggaggctga ggtcaggaga agaaagacaa gactactcgg aagaatgtgg gagaaaagaa      840

gagtggccag ttccaggggt agctccaaaa gagactgcag agctgtccga gaccctgaca      900

agggaggccc aaggcaacag ttccgcagga gtggaggcag cagagcagag gcctgtggaa      960

gatggcgaga ggggcatgaa gccaacagaa gggtggaaat ggaccctgat aatgagcctg     1020

gcagggaagg gcaaccaaca tcttgtaact tgctttcccc accctgtttc tgggggcaga     1080

gccaattgcc caatttctac cctaatccaa agtccctggt gtgggtgggg ttaa           1134


<210> 4560
<211> 2710
<212> DNA
<213> Homo sapiens

<400> 4560
gtaactctac ggcctagcaa ccgttgccaa ggagctcgac tctgggagcg gtctagagcc       60

cgggcgcctc ctggggggtg gggaaacggt ttcgtgagga gaatttgagt taaaattata      120

agacctaatt atgagtgatc aaattaaatt cattatggac agtctcaata aggagccctt      180

taggaagaac tataatttaa tcacgtttga ttccttggag ccaatgcaac tattacaagt      240

tctcagtgat gttctggctg agattgaccc aaagcaactt gtggatatca gagaggagat      300

gccagagcag acagccaaac gaatgttgag ccttcttggt attcttaagt acaaaccttc      360

aggaaatgcc acagatatga gtacttttcg tcagggtttg gtgattggaa gtaaacctgt      420

aatttaccca gtgctccact ggcttcttca gaggactaat gaactgaaga aaagagcata      480

tttagctcgt tttttaataa aacttgaggt accaagtgag tttcttcagg atgaaactgt      540

ggctgacacc aataaacagt atgaagagtt aatggaagcc tttaaaactt tgcataaaga      600

atatgagcag ctcaagatat ctggattttc tacagcagaa ataagaaagg atatcagtgc      660

aatggaagaa gaaaaggatc agctcattaa gagagttgaa catttgaaga aaagggttga      720

gacagctcag aatcatcaat ggatgcttaa aatagcaagg caacttcgag ttgaaaaaga      780

gagagaagaa tatcttgcac aacagaaaca ggaacaaaag aatcagctat ttcatgcagt      840

gcaaagattg caaagagtac aaaaccagct gaaaagcatg cgccaagctg cagcagatgc      900

aaagcctgaa agtttaatga agaggctaga ggaggagata aaatttaatt tatatatggt      960

aactgaaaaa tttcctaaag aattagaaaa taagaaaaag gaattacatt ttttacaaaa     1020

agtagtttca gagccagcta tgggccattc tgatcttctt gaacttgaat ctaaaataaa     1080

tgaaataaac acagaaatta accagttgat tgaaaagaaa atgatgagaa atgagcccat     1140

tgaaggcaaa ctctcactgt ataggcaaca ggcatctatc atttcccgta aaaaagaagc     1200

caaagctgag gaacttcagg aggccaagga gaagttagcc agcctagaga gagaagcatc     1260

agtaaagaga aatcagaccc gtgaatttga tggtactgaa gttttaaagg gagatgagtt     1320

caaacgatat gtcaataaac ttcgaagcaa gagtacagtt ttcaaaaaga agcatcagat     1380

aatagctgaa cttaaagctg aattcggtct tttgcagagg actgaagaac ttcttaagca     1440

acgtcatgaa aatattcaac aacaactgca aactatggag gagaaaaagg gtatatctgg     1500

atatagttac acccaagaag agctagaaag agtatctgca ctgaagagtg aagttgatga     1560

aatgaaagga cgaacattgg atgatatgtc tgaaatggtg aaaaaactgt attcattggt     1620

atctgaaaag aagtcagctc ttgcctcagt tataaaagag ctacgacagt tgcgtcaaaa     1680

atatcaagaa ctgacccagg agtgtgatga aaagaaatcc cagtatgata gctgtgcagc     1740

aggcctcgaa agcaatcggt ccaaattaga acaggaagtt agaagactcc gtgaagaatg     1800

tcttcaagaa gaaagtagat accattatac aaattgtatg attaagaacc tagaagttca     1860

acttcgtcgt gctactgatg agatgaaggc atatatctct tctgatcaac aagaaaaaag     1920

aaaggcaatt agggaacagt ataccaaaaa tactgctgaa caagaaaacc ttggaaagaa     1980

acttcgggaa aaacaaaaag ttatacgaga aagtcatggt ccaaatatga aacaagcaaa     2040

aatgtggcgt gatttggaac aattaatgga atgtaagaaa cagtgctttc tgaaacaaca     2100

aagccaaact tccattggtc aggtaattca ggagggtggg gaggaccggc taatactgtg     2160

aattcttgtg tcatcgtttg gggttttact tgataccact agctataagc ctaatctcat     2220

aatgtatttc ttttttgaaa ctgatttgta tagcattttg ttttcagaag agccattctt     2280

tattaagttt tcatagaaaa taatgttaag gtagatttag tttgaatgtt ttttcatatg     2340

aaaaagaggc ttttattctt ttccatagtt tagacatcac tggcgtcttc tgagttttat     2400

gagacaggaa actaagttta ctatctgtaa atgtaaacat atgtccatta agaaacatgt     2460

agtttttttt tagaatgtaa taacccagtg gcttactgtt tttcttaatc tcttttaaaa     2520

aaactttaga agaatctttt aggaactaat atctcttgtt ctgaagaaac atttatctga     2580

cgttcagcag ttcctacagt tttacttcag tttatttttc ttctgtaaaa tgcaagaaaa     2640

tttaatattt tgactaacat gtcttttctg tttgtatcat ttaaaggcaa ataaacttgg     2700

tacgtatttc                                                            2710


<210> 4561
<211> 563
<212> DNA
<213> Homo sapiens

<400> 4561
gtacgtcaca ccgtagaggg acggcgcggg aggaataaat ttctctgtga ttggttggtg       60

aaggttttca aaccggagct gtgggcgcgg cgctgctctg ccgttggaaa gatggatact      120

atgatgctga atgtgcggaa tctgtttgag cagcttgtgc gccgggtgga gattctcagt      180

gaaggaaatg aagtccaatt tatccagttg gcgaaggact ttgaggattt ccgtaaaaag      240

tggcagagga ctgaccatga gctggggaaa tacaaggatc ttttgatgaa agcagagact      300

gagcgaagtg ctctggatgt taagctgaag catgcacgta atcaggtgga tgtagagatc      360

aaacggagac agagagctga ggctgactgc gaaaagctgg aacgacagat tcagctgatt      420

cgagagatgc tcatgtgtga cacatctggc agcattcaac taagcgagga gcaaaaatca      480

gctctggctt ttctcaacag aggccaacca tccagcagca atgctgggaa caaaagacta      540

tcaaccattg atgaatctgg ttc                                              563


<210> 4562
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 4562
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaatctgc ctaatcacct ggttatcccc acagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct ga                                              1522


<210> 4563
<211> 2674
<212> DNA
<213> Homo sapiens

<400> 4563
tgtttaccta agcaagcctg ggcaatggcg ggcgtccctc ccccagcctc gttgccgcct       60

tgcagtttga tctcagactg ctgtgctagc aatcagcgag attccgtggg cgtaggaccc      120

tctgagccag gaactgaagt taaaagatga agaatgtgag aggctttcaa aagtgcgaga      180

tcaacttgga caggaattgg aagaactcac agctagtcta tttgaggaag ctcataaaat      240

ggtgagagaa gcaaatatca agcaggcaac agcagaaaaa cagctaaaag aagcacaagg      300

aaaaattgat gtacttcaag ctgaagtagc tgcattgaag acacttgtat tgtccagttc      360

tccaacatca cctacgcagg agcctttgcc aggtggaaag acacctttta aaaaggggca      420

tacaagaaat aaaagcacaa gcagtgctat gagtggcagt catcaggacc tcagtgtgat      480

acagccaatt gtaaaagact gcaaagaggc tgacttatcc ttgtataatg aattccgatt      540

gtggaaggat gagcccacaa tggacaggac gtgtcctttc ttagacaaaa tctaccagga      600

agatatcttt ccatgtttaa cattctcaaa aagtgagttg gcttcagctg ttctggaggc      660

tgtggaaaac aatactctaa gcattgaacc agtgggatta caacctatcc ggtttgtgaa      720

agcttctgca gttgaatgcg gaggaccaaa aaaatgtgct ctcactggcc agagtaagtc      780

ctgtaaacac agaattaaat taggggactc aagcaactat tattatattt ctcctttttg      840

cagatacagg atcacttctg tatgtaactt ttttacatac attcgataca ttcagcaggg      900

actcgtgaaa cagcaggatg ttgatcagat gttttgggag gttatgcagt tgagaaaaga      960

gatgtcattg gcaaagctgg gttatttcaa agaggaactc tgatgctctg cgtgggacca     1020

tgcctgaact ccccgaataa ctgaaaaatg gctgaatatt tttatggtta cttgatattt     1080

atttccaagg agtgagccta agactttttt ccccttttgc aaattgctct aagaagtacc     1140

atgatttctt ttaaactgat ctatgctgtg tttgcttatt ctttagttga acacactatg     1200

aagaattcca ggtgtactag tgaatgtaat ttatagttgc caaaaaaaaa aaaaacctga     1260

aataaataaa tgttagattg aatgtgtgta cattttctct tctagctctg acatggcatt     1320

tagggttagc agaatgtatt aaatagtaat tttcaaacta cacagtagct tccttccttg     1380

tgagaggcaa gaaagaagtc tgagtggata gtactcactt tccaaggccc ccacctctag     1440

aatggcttta tttttatctg ttttctatat tgggtttcaa aaaagatttt atttgaagaa     1500

atacttctgc tgctacaaag tttgaaagtt actattttaa ttattctgct ctctgtaact     1560

gaaagaatcc ctttattttg gttattcatt aaaatataat agaaggcagt cagattttat     1620

cccagagatg tattcctgag tgtcttgata tagtgtattc atgttttata tgtgttgacc     1680

actatattgt cattggaggg acatagatgt aaatgagttt gacgtgtgtc aaaggggttt     1740

aaaggggtgt ggattgaatg aatggtacgt gcgaagtata tgctgattat agaaccactt     1800

gatctctgca ttccaaattg taaaactgac tcaactggag aaattataac aaagaggttt     1860

gtggtagaca tgtaataagt atagaaaagc aaaaagaaaa gagaaactgc tttagtttct     1920

gtttagagaa agctgctgtt aatatttttg gatagtagcc tttcagcttt cagatatttt     1980

ctacttacat atgcatattt ttgaaacaaa aagtaggctt tttttttgct ttttaaacct     2040

aaacattaaa tatattttcc cttgggtaaa cctacacatc ctaatccctg tttatagaat     2100

tttaacataa tttaattgtg tttggagatg aggtggtttt cagtttattt ttcatattat     2160

aatgctgtga cgagtatcct tatctgtaca cttctgaaca ttgtggagtt ctttcatgtg     2220

gatgcctgga gataaaattg tgtcgagata tatatgtatt tttaaatgtt tgatctgcat     2280

tgctagattg ccatccagaa aagttaatca atttgtattc acagcagcag tgtacaagag     2340

ggctggtttt ctgaagataa catttttttc agtcctgttc agaggtttgg tcaatcttac     2400

ctgtagatga cttcagccac caggctggat gggagcccac agacaaaagg acattggtgt     2460

atgttatggt gaaaaccatc agtaccatgc ctagctcaag aatgtgaaat tgaacctgaa     2520

aaaaactttg aacctacaat tttatgttct gaaaatagtt attctaatgt gagggcatta     2580

ataagaatat gtaccatcaa agcttcagaa gattttccgt acaaactaaa atcacttttg     2640

gagaaagtac ctaaataaaa agagaaacaa atcc                                 2674


<210> 4564
<211> 1522
<212> DNA
<213> Homo sapiens

<400> 4564
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca       60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa      120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt      180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc      240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct      300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga      360

ggaggatgtc tgccaagagc acggagagaa gatctacttc ttctgtgagg atgatgagat      420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct      480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa      540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct      600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt      660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt      720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct      780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag      840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga      900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa      960

gatgtttctg gaaaatctgc ctaatcacct ggttatcccc acagctcaca tttctctaga     1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc     1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct     1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca     1200

tgggggcagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg     1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct     1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct     1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac     1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc     1500

cagtttctcc ctgagctcct ga                                              1522


<210> 4565
<211> 2586
<212> DNA
<213> Homo sapiens

<400> 4565
ccttccagga caccgtcgcc ttcccggccg cgtcggagtc cggcggcgac ctgcctctga       60

aacatggcag gctcggatgc tgagtgggta accattgcca ataaccttct ttttaagtgt      120

catatacatc tgagaataca tgaacttcaa gactgtgatg ctaatgtttt tattgctctt      180

tatcagtcta ttttgggaga aaaggtacca gacctcatag ttattcctag gagtcaagaa      240

gatgatgcac acaatgtaca agcagtaatt gattcactgg ccttggacta cttgcaggtc      300

agcttgtctc acataacagg agaaaatata gtgaaaggag ataaagaatc tattaagaat      360

ctcctggaaa tatttgatgg tttgttggag tatcttacag aacgcatcag tgaaacatct      420

catgagaaaa gtgctccttg tcttctgaga tgttgggccc ctcttgggat ggagatgaag      480

cagaatccac tggtgaaatc attagacttg gagacacagc acacaccttt tctctaagaa      540

gtaatggtgc tcaatgtcct aatgaaatgc tgtctaaaaa agccttagcc tcaccaagtt      600

ctaaatcaca tgaagatatg ttgtaccctc ctagtgtttt gtccaagagt aggacatcct      660

ttgttgaaga cacggaaacc ctttctgtga gtgggattcc aaatgctagg aagctagggg      720

agcctatccg agcagctatt cctttacatc caccctacca cccttcagag cctcgagcac      780

cctgccccat aggaaaagaa tacttgcatt caagtcactg ctccccagcc gtaaattcta      840

ctggagagca tacggaattt tctggggatc tagatgatgg acttttctta atttccaagt      900

tgcctaaagg cagcaaatgg gaagtatatc cagctcaggt ccaagggcct aggacaagga      960

agcctcccaa aggaaaaaga aatgaaaaca gagctacagc ctcatcctgc aattcacctt     1020

tcccccagag gccaagaaag agattaacag aacaagaatt acatgatgta tcagaaaaac     1080

tctctcagcg gctttctgaa ctagattgga tgttaaaaag tgctctgggt gatcggatta     1140

aagaaaagac tgaccataaa gaagaaaata ctggaaatga ggaggtagag gatggaactg     1200

aggagacact gtctcagcac agtgatggca tcgtggagta tgggccaaag aagtcaaggc     1260

caggactttc catgcgtaga aagccaccct acagatccca ttcgctctct ccatctccag     1320

ttaacaaaca caaacagttc cacttggaga gaaaaaggca gcgcaagcca agagaaacag     1380

atgtccgcca attccaagca caggcgttta ctgaagcatt tgaaagggaa ctaagaagac     1440

ataaagttca agagaatatt ggacctctaa gaatacatga gaaggaggag gaaacagaaa     1500

aaatatacag aggagaagct gttcgtaaag gaactccaga atgtagtcag ccctggaaga     1560

tttactctag aaaaaccaca acgcagagtc taagaggtgg cctcccaaag ccaaataaag     1620

cagttccaat gaaagtaagt gaacacagtc tcctgcccct tatgctggag cagtttccgt     1680

ttctttatgt ttctggccca acactaagca aaatgtggaa acagcaaatt gcacaggttg     1740

aacagcttaa gaaagaagca tgtagagaaa atcgatcaaa gaagaaactc caagatgaaa     1800

tagaagaagc cctaagaagg catgacctcc ttactaccct tgtcaagaaa gaatatgaac     1860

ataacaagag actgcaagac ttcaaggact gcattcgtag gcaaaggttg acccaatcaa     1920

agataaaaga aaatcgacag caaatcgttc gtgctcgaaa atattatgat gattatagag     1980

ttcagttgtg tgcaaaaatg atgagaatga ggacccggga agaaatgata tttaagaaac     2040

tgtttgaaga aggtttaaac attcaaaagc aaagattacg agacctaaga aactatgcca     2100

aagaaaagcg agatgaacaa aggagacgcc accaggatga actggactcc atggagaact     2160

actataagga ccagttttca ttgctggcag aagccatatc acaggaacat caagaactta     2220

aagccagaga gaaatctcag gcccagacat tacataaggt gaagagggag ctgagatcta     2280

agatggagaa ggaaattcag cagctgcagg acatgataac acagaatgat gatgatgttt     2340

tcttccggga actggaagct gagcgcttca gatctcggct tcagctggct tcctttcagt     2400

acagtaaaag tccctcccta tgaggccaga cttgataata gtaggtgaag gttctggagg     2460

cctttaccag gacagagcta gaatcgagcc agtaaacagt ctaagccaga aaaataattt     2520

tcaaatgctt tacctgtatt ttcattccag tactttttat gattttttaa ataaaaattg     2580

ttttct                                                                2586


<210> 4566
<211> 609
<212> DNA
<213> Homo sapiens

<400> 4566
gggcagcgcg cgaggaccag gccgaggagg aagtggcggc ggcggcggcg gactcggcct       60

gtgggcgatt tcctccggac ccaggctccc cgcccgagga ggaagatgca gacctttctg      120

aaagggaaga gagttggcta ctggctgagc gagaagaaaa tcaagaagct gaatttccag      180

gccttcgccg agctgtgcag gaagcgaggg atggaggttg tgcagctgaa ccttagccgg      240

ccgatcgagg agcagggccc cctggacgtc atcatccaca agctgactga cgtcatcctt      300

gaagccgacc agaatgatag ccagtccctg gagctggtgc acaggttcca ggagtacatc      360

gatgcccacc ctgagaccat cgtcctggac ccgctccctg ccatcagaac cctgcttgac      420

cgctccaagt cctatgagct catccggaag attgaggcct acatggaaga cgacaggatc      480

tgctcgccac ccttcatgga gctcacgagc ctgtgcgggg atgacaccat gcggctgctg      540

gagaagaacg gcttgacttt cccattcatt tgcaaaacca gagtggctca tggcaccaac      600

tctcacgag                                                              609


<210> 4567
<211> 3796
<212> DNA
<213> Homo sapiens

<400> 4567
agagagagaa gcaggaccgt ggggtgggag agggtgtcag gaggccggac gtcgcagccg       60

gggcctcgca gtgcttttgg ggacgtctgg tgctggggcc cggcctggag actaagggaa      120

ttcggggcac tgggggcgtt tgctggacca gcgctctcga cggttgcgca cgccagccag      180

ctctcagtgt tgaggattcg gaggccctgc cggtcccccg cgagtaaacc ttgtttatac      240

gcatcctccg tggctttttt taaacccgta gtttattatt tccaccaatt cggctcgaat      300

gctgaaattt taacagtagt taaatctcac tgtgaaggcg ttgccacgtt taaacaaatc      360

tcttttaatg aaagatggaa ggttggggcg ggtttagaat gaaaagatgc tctacgtggc      420

tccgcgttcc tcctgagaga gatacccggg caaccttgat taactctgga ctgcagggaa      480

gtgacagtct ttgaaatgcc tgagtgggat ttaaactgaa attcgagtgt cctttgtatt      540

taaaacccgg atatttttct ttcacggttg acatttttca tgtaccgcaa aaatccgaga      600

ctcctattta aaccggctgt ggtaacagcg gtggtgatta actagggtct tagtttgcaa      660

acaataggga taaggtttag ttccaccgcc ctgccttttc gcctccctca ttcattggcc      720

aactgggtta ttatggagtc tttttggaag taatccacta atgctttgag catctgtttc      780

tttgggtttt attgttttgg gctttttttt ttttaatttt taatgatgaa ctatctgaaa      840

tatggaactc tgtctaaccc agtagtaaag tcatgccttc tggaatggtt taaaagtgtg      900

ccataaatgt aaactataaa tgggaacttt aaatgtgtac aagttttaca tctttattaa      960

aaatcgtcag ttttgtgtag cttaatacga aaagatattt taagttcctt ttaaggtttt     1020

aacaccagga tattgtacca tttaaatgta taaatatatt tttaaaagta ggacttcata     1080

ataatcagaa taaaaacatt ccttcatcca gtgctggcta ttccagcacc cccattcttc     1140

ctgctattga acttttaagt gttagccagg aagaatagac ttaaatactc ggtgtttagg     1200

atagttaaaa tatgagcatt tttcatatag tgtctttgta acagagacat tggctatact     1260

tctctaagcc tttctgctca tttcatatgt gctgtcaaca aatggtaatt tttaaaaatt     1320

gatcgctata tcctaatctc tttatttttt tctacctgaa ttattttcat tggatttttg     1380

ctctttctta aatcagtgag tttcagaatt tattgtgtat acactacctt gaaggatttg     1440

ttcaacaatg ctgattcctg cacttcagat ctcagattct gaatcagtag gtctggagga     1500

tggcattgaa cagtctgcat atttaactga aagtaaaatg aatgaaagta aacctggtga     1560

ctcacagaac cttgcttgtg ttttctgtcg aaaacatgat gactgtccta ataaatacgg     1620

agaaaagaaa actaaggaga aatggaatct cactgtacat tactactgtt tgttgatgtc     1680

aagtggaatt tggcagagag gcaaagaaga agaaggagtt tatggttttc taatagaaga     1740

tatcaggaag gaagtgaata gagcttctaa actgaaatgc tgtgtttgca agaaaaatgg     1800

tgcttcaatt ggatgtgttg caccccgatg taaacgaagt tatcatttcc catgtggact     1860

tcagagagaa tgtattttcc agtttactgg caattttgcg tcattttgtt gggaccatcg     1920

acctgttcaa ataattacat ctaataatta tagagagtcc ttaccatgca ccatttgctt     1980

ggaatttatt gagcctattc caagttataa catattacga agtccttgtt gtaagaacgc     2040

ttggtttcat agagactgtt tacaggttca agcaataaat gcgggagtgt ttttctttag     2100

gtgtacaata tgcaataata gtgacatctt tcagaaagag atgttgagaa tgggaattca     2160

tattcctgaa aaagatgctt cctgggaatt agaggaaaac gcttatcaag agcttctgca     2220

gcactatgag cgttgtgatg ttcgaagatg tcgttgcaaa gaagggcgag actataatgc     2280

acctgatagc aaatgggaaa taaagcgctg tcagtgttgt ggttccagtg gcacacattt     2340

agcctgctcc tcattacggt catgggagca aaattgggag tgtttggaat gtaggggtat     2400

tatctacaat tcaggagagt tccaaaaagc caaaaaacat gtattaccca attctaataa     2460

tgtggggatt acagattgtt tgttggaaga gtcatcacct aaattaccca gacagtcacc     2520

tggatcccag agtaaagatc tactgaggca aggcagcaaa tttagaagaa atgtatcaac     2580

actattaata gagttaggat tccaaattaa aaaaaaaact aaaagattgt atatcaacaa     2640

agccaatatc tggaatagtg ccttagatgc attcagaaat cgaaacttta atccttcata     2700

tgcaattgaa gtagcatatg ttattgaaaa tgataatttt ggaagtgagc atcctggatc     2760

aaagcaagaa tttctgagtc tcttaatgca acatcttgag aactcatcat tgtttgaagg     2820

gtccttgtca aagaacttgt ctctaaattc tcaagctctg aaagagaatc tttactatga     2880

agctggcaaa atgcttgcca tttctttagt tcacggtggt ccttcacctg gtttcttttc     2940

taaaaccttg tttaactgcc ttgtttatgg accagaaaat acccagccaa ttttagatga     3000

tgtttcagac tttgatgtgg cacagattat aatcaggata aatactgcaa caactgtagc     3060

tgacttaaag tcaataataa atgaatgcta taactacctt gagttaattg gatgtctcag     3120

acttataacg acattaagtg ataaatatat gttagtaaaa gacatacttg gctaccatgt     3180

aattcagaga gtccacacac cctttgaaag ttttaagcag ggtctgaaaa cccttggtgt     3240

tttggagaaa attcaggctt atccagaagc attttgtagc atcctgtgtc ataaacctga     3300

gagtctttct gcaaaaatcc ttagtgagct ttttacagta cacacattac ctgatgtgaa     3360

agctttgggg ttttggaaca gttacttaca ggctgttgaa gatggtaaat ctacaacaac     3420

aatggaagac attcttattt ttgcaactgg ttgcagttcc attcctccag ctggatttaa     3480

acccactcct tcaattgagt gtctgcatgt ggattttcct gttggaaaca agtgtaataa     3540

ctgtttagca attcccatca ccaatacata taaagagttt caagaaaata tggacttcac     3600

cataagaaac actctaagac tagaaaagga agaaagttct cattacattg gacattaaaa     3660

tgtttccttg aacaaagaga agcttcttta aaagctgcta ttgataactc tcttttattt     3720

cactaacctt ttcatcatca ctttgaacaa actagttagc ttcttgacct aataaaattt     3780

atgatatgaa tataaa                                                     3796


<210> 4568
<211> 6306
<212> DNA
<213> Homo sapiens

<400> 4568
cgcagcttgt tggctcgcta tataaaggag agaagcgggc ggaccggacg gctggagctg       60

cagccggtgg cggcagcggc ggcgcaggga gcggtgaccg gtggtggttt ccctccttgg      120

cgcggggtgg ggagcgggca acgccccccg gacccctgaa gggtcgtggc tttttttttt      180

tttttaaggc gattctcgag gttttcagct gcgggaggag tgcccccctc ctcctcctct      240

ctccgctctc ccctactcct tcaggattga ttttgtttaa aattttttcc ccaatcttgc      300

ggtgatttgg gtcaccctcc gggtgttata gttttttttt ttttggtttt gtttttatct      360

tgttttcttg gggttgcccc ctcttgtttg tgttgtgtgt ggaaatggcg aactcggcaa      420

atacaaacac cgtgcctaaa ttatacagat ctgtgattga agatgtcatt aatgatgtga      480

gagacatctt tctggatgat ggagtggatg aacaagtact gatggaacta aaaactttat      540

gggaaaacaa actaatgcag tccagggcag tagatggatt tcattcagaa gagcagcagc      600

ttctactgca agttcaacag cagcatcaac cccagcagca gcagcatcac caccatcacc      660

atcatcagca agctcagcct cagcagacag tacctcagca agcgcagacc cagcaggttc      720

ttattcctgc atcacagcaa gccacagcac cacaagttat tgttccagat tctaagttga      780

tacagcatat gaatgcatca aacatgagtg ctgctgctac agctgctacc ttagcactcc      840

ctgcaggtgt gactcctgtt cagcagatat taacaaattc aggccagctt cttcaggtgg      900

tcagagcagc caatggtgcc caatatatct ttcagcctca gcagtcagtg gttctacaac      960

aacaggttat accacaaatg cagcctggtg gagtacaagc tcctgttata cagcaggtgc     1020

tggctcctct tcctggaggg atttcaccac agacaggtgt catcatccag cctcagcaaa     1080

tcttatttac aggaaataag actcaagtta tacctacgac agtggcagca cctacaccag     1140

cccaagcaca gataactgca actggccagc agcaaccgca ggcccagcct gctcaaacac     1200

aagctccatt ggtcttacaa gttgatggaa ctggggatac atcatctgaa gaagatgaag     1260

atgaagaaga agactatgat gatgatgagg aggaagacaa agagaaagat ggagctgaag     1320

atgggcaggt ggaagaagag cccctcaata gtgaagatga tgtgagtgat gaggaaggac     1380

aggaactctt tgacacagaa aatgttgttg tatgccaata tgataagata cacagaagta     1440

aaaacaaatg gaaatttcat ctcaaggatg gcattatgaa tcttaatgga agagattata     1500

tattttccaa agccattgga gatgcagaat ggtgaagagt tgcttttttt cttttataaa     1560

taaaagaaac ttaaaaaaaa tgtaaagcgg acagtttgaa acttggggca tatgccaacc     1620

aaaacttcgt ttctgcatgt cagaaaagtg cagtagaagc aaagctactg gaacaaagat     1680

agaccttgac aacatagaca ctacttactg gcaagccatg gaactgtagc acctagggtt     1740

tttgggtggg agggttgggg ttttgtgtag gaaaaccata attgttgatt ttaaatacag     1800

gtacctgcca ccggtaatta gcatgtaaag ctttgtctat attccttcct ccaacttggg     1860

ttcaatcaga agatacttgt tggaatgaac tgaagaaact tcccttttga tagattgaac     1920

tgaaactgct tattgtatgt ggttatattt ggtaaaagtt gcgtgtgagc tttttacaaa     1980

agggtaagaa ttgtgttgaa ttttaattca cttgtataag aaaacaattt aaaactctca     2040

taataggtct taaatatttt tacttgctat tctccctcag tgatatatac ctcttccttt     2100

ccagctttat gaaacatcta tttaagattt aaagttatca gtgatcatag tttggagata     2160

aaatttgacc caggaatgaa tatttatttt aattaggttt tcatacttat taaatgtaat     2220

taaagacttg ggtcttgtct gagttcagtg gaattgaaac cacaacttta atttccttac     2280

agaaaaactt aatttgtttc ttttagtgcc acaccttaaa aagaaacccc aaactagctc     2340

ctcaggaata tagttttatt ttgcaagcat accatctagc tgaaattgta tacacatgaa     2400

tatatgtaga cttttcctgt tgggctgaag tgtgtgctta taaatgtgtt tagtttttaa     2460

gctaaacatt cagttaacag tctgtgcatt gattagcata gggcaggtgg tgaggacctg     2520

gatttttatt aaacagttta gtaattataa aagtttcttg tgtttactag taaagaattt     2580

taaaaatcta ttctaattca acaagttttt aaaatcaact ttgtaatttg aggggaaaat     2640

ttggggggaa gaggtgggtg ggccactaag ttacctctct ttcatttggt ggcccttcca     2700

ggccattgaa aataaagacg ttggctccag tttgcacatt gggaagaaag catagaaatt     2760

tgacttgtat attaaaaata atagaaatgt aatatgtata ttaagaatgc ataggtctgt     2820

attctgtaag gggctctgaa gaacaatatg gcactgctgt gttcagtgtg aattcactgc     2880

ctgggagaac tgcaggaatg cttgtcttca ccattgtgtt cttacaacga attcaacttt     2940

ccatggttta tcttgacaaa atttacatgt gtttaggtta cttgtatatt gatatatttt     3000

tttaatcttc agtttttgtc ttccttttgc ctttgtgttt tcagaagtaa cacatgaaca     3060

ctttttaaag tacattacag agaagaaaac tgtgagctat tatatagtgt ttctttttta     3120

acacaaatct tttaacttta aaaaaaggca aaaatttttt ttttctactt cccacccagc     3180

ttaccacctt gatctcttta acttatgttc taaactttgg tgttaatggt ggtgtctagc     3240

atgctagtag ttagatttta tttagatgcc ataactggta atacagcttt tattttgact     3300

atattaattt agttttttga ggggaagttt gtttattctg tgactctcaa agcacacaga     3360

ggttttaaaa tatatattat taagactgag agaagaggaa atgggaggga gtaacatcac     3420

agaagtgctg ttgttcaact gttcttcaat atagttgcta gtaggtttgt atttactcag     3480

taaggaagtc agtgacctga actacctata aaaattcagc agtgctgcag tgttgcttaa     3540

gtgaaaccct ttggctatct agtagttttt atgctactga aacttggatt actgtatgat     3600

attcagcttg tcttgggccc tctatgtaga caaacattca tattcatagt agtgttgtat     3660

actggcctgt ttttataact ttatttttca aatattaaca accactgctt tcagagtggt     3720

tattttgtta tttttgaagc aggaaataac catttgtatt tgcacctgcg tattgcatat     3780

gaattatggt atacttggca aatgcttttc ttttacctgt gaaaattctg aaagctggtc     3840

caagctacat tgcataccaa attgtgctct tatatattat ttgcatcgtg tcctttttaa     3900

tcaaatagca tgttttagtt ttattatagt agcttttgct gtaagaatgt cacttgctta     3960

tcttttattg tacttgaatt cttaatcatg cttttaacat tgtatttaac aaatcatttc     4020

gtattaggtt ccattaaaat gtcattcctt tgaaaaggca agggatttcc actttcagaa     4080

tttgaaaatg aaagtagcat gtttatctaa aggcagaaaa tagttcggac ttggtattat     4140

gaaaataagt aatggtttct ggagaggatt tgtttagatt tgcacagatg gcgatggcac     4200

cttttactta aattaacatt aatcaacagt gctaaggaaa atttacacaa aattacaaga     4260

taaaacatgg aaatgtgtgc ctttcagtat acaaactctt gcttggtggc catttgggta     4320

atcagaccat ttgaatgcct gagagcatgt ttaatttctg tggagtgcca catatggcta     4380

aaacaactct ttaatgtgca attaatttct agagtaaaat gtctgttatg tgagggggat     4440

ctttatgttg ggcttttcta ttttttaaat gttcacattt ctttctgtta attaaaatgc     4500

catcataatg tcacatttac actgttgcct cttttaaaag caaagccact ttcttgttct     4560

aagattacat caagacttga gcagtgtgta gtaattaaaa tgtgtgctta atgagcataa     4620

tagattctgg ttttaggaaa taacatatag cttttatatg aatattttct tttgctataa     4680

tgaaagtcac agattttttt tttcctggct tttatggagg aatgaaaaga gttgtctccc     4740

tctaagagta tactattttt gattctcata gcaataatgt caccattctt atcagagggt     4800

aaatacccct tgtataggaa aacagacata atttcctctt gggagttctc tttatgactt     4860

agcattttct tctacttgag aaaattcctg tttttccgat tatttcatct tgaactttct     4920

tttttttaag cttttgtgca atgtaatagt ttgttgatcc atctttgtac attttcattt     4980

tatttcatgt ctttctctca cctacctgtc agaatcagct atagcagatt ttgaattctt     5040

tagttaaaaa atagttgctt tacttgtttc ctcatgagtt tgttaaatag ctttgcattt     5100

tagtcctcta ttatgctatg aaaattatta cgaagtttat attgttccct ttttaagcct     5160

gccttactct tgtcttttgt cattgtctat ggtttaatga agaacacacc aaactaacat     5220

ttttgtttat tttgaggaac aaaaaaactt ttctctttta agggaagtta ctacacattg     5280

agttagtaac tactctttca gtcaaggttc cttaatcagt ccagtctaca tcaggactat     5340

gacttggggg gcggggctaa tcctttttgc tgttctgagc tactattgtc aactgctgtt     5400

gtacatactg ttatgtgtaa tggcgtaaat atatttatta tgtttgtaaa attcattgca     5460

gatcaaggtt gctcttctgt gatatatggg atattatgtt ttaaagacca tcttggaata     5520

caattagaga acttagtatt ttgatgtact aagacctatt ttaagtttaa tattctactt     5580

tgcaaaaact ttaattaaag atgttattta aaaaaaaatg ttgcttgctt tgcttactag     5640

tatatggcat tgttatagat aattgaataa aatacaattt agaaaggaaa atgctttaca     5700

ttgttaatga gaattccatt taacaacaac aaaaagatgc taaattctgt accttaaaga     5760

taagtagatt gagatgtcaa tttgaattag taaactgtgt tacaaatgat taatactagc     5820

ttttaaaaag ttgtattttc caggcacaca ggaatttagg ttgggcgaat tcacactaac     5880

aaattataac taaaaattgg tataattaac attgtttttc aaaataaaga ttactccttg     5940

tgaaatatta ataattaaca tattgtatta aataagtatt tctactccaa agtatagatt     6000

acttaggata aaaacattgt tatttctctg tttagtcaaa ccacttcctc ttagttcaga     6060

ggttataaat aattgcatat taggagaatt ggattactga ggtttgtatt gcgtattgaa     6120

tatattttgt gttattttag aagataataa ttagcaggta ttttaatttt atagttaatt     6180

cagctgaatc attaagaagc tcgccttttt gtattttttt atcctgttaa cagactatct     6240

agaaaacatg caaattttaa ctattaacat aatcataata aagatatctt atttattgcc     6300

agcaaa                                                                6306


<210> 4569
<211> 501
<212> DNA
<213> Homo sapiens

<400> 4569
agtcgcctcc ggaggaagga agaagaggac gccgggcgcg cagcatcatg cttgggctag       60

tggccccatc tcaacatggc tacttggaac agcttgagct gtgtgctgtg actgaactaa      120

tctgattaaa gtgaccaaga agtccgggcg cagtggttca tgcctctcgg tgctgattat      180

cacaactgtt tggtgaccta cttcactgac ctgtgaggat tccttccctt caggtactgg      240

attcttgatc tttctgcatc atcaagaatg gaaacagact gtaatcccat ggagctaagc      300

agtatgtcag gatttgaaga aggttcagag ctgaacggtt ttgaaggaac tgacatgaaa      360

gacatgaggc tcgaagctga agcagttgta aatgatgttc tctttgctgt taacaacatg      420

tttgtctcga aaagcctgcg gtgtgcggat gatgtggcct atatcaatgt ggaaacaaag      480

gaaagaaaca gatattgcct a                                                501


<210> 4570
<211> 833
<212> DNA
<213> Homo sapiens

<400> 4570
attctcatcc ctgtgctcag agctctcaag cacccacgat ggccttctca ggccgagcgc       60

gcccctgcat tatcccagag aacgaagaaa tcccccgagc agcccttaac actgtccacg      120

aggccaatgg gaccgaggac gagagggctg tttccaaact gcagcgcagg cacagtgacg      180

tgaaagtcta caaggagttc tgtgactttt atgcgaaatt caacatggcc aacgccctgg      240

ccagcgccac ttgcgagcgc tgcaagggcg gctttgcgcc cgctgagacg atcgtgaaca      300

gtaatgggga gctgtaccat gagcagtgtt tcgtgtgcgc tcagtgcttc cagcagttcc      360

cagaaggact cttctatgag tttgaaggaa gaaagtactg tgaacatgac tttcagatgc      420

tctttgcccc ttgctgtcat cagtgtggtg aattcatcat tggccgagtt atcaaagcca      480

tgaataacag ctggcatccg gagtgcttcc gctgtgacct ctgccaggaa gttctggcag      540

atatcgggtt tgtcaagaat gctgggagac acctgtgtcg cccctgtcat aatcgtgaga      600

aagccagagg ccttgggaaa tacatctgcc agaaatgcca tgctatcatc gatgagcagc      660

ctctgatatt caagaacgac ccctaccatc cagaccattt caactgcgcc aactgcggac      720

aggaaggatc tgactgccga tgcacaggag ctgaaagggg agctatactg cctgccatgc      780

catgataaaa tgggggtccc catctgtggc gcttgccgac ggcccatcga agg             833


<210> 4571
<211> 3244
<212> DNA
<213> Homo sapiens

<400> 4571
actccgatca gctgatccca actgacaaca ggagaggagg aagcccggga ggcaacgaag       60

gaggagggtg gcggagatgg agatgaggat ggatctgccg gtgtcctgag gaatagcctc      120

tgcccccact ggcgccctgc ggccccccga cgccgccttg ctgcggccga gcttctcagt      180

ggtatcccct gaaatactga cttcaggtcg aattatattg aaaagctcct gaccactttc      240

tttcattacc aaaactttgt agctgatgtc caaccgatga acccaccacc gtgaacccat      300

cagacctctc tcagatagcc ataaaagacc cttccaagtc aattttgacc acatctttgc      360

ttgcacttta tggaggatga aaccatcaaa ccaaatcaac gttgctgcta atacaagagt      420

cttagaggca gcaaattaaa aatttgaaca tttgtttgtg aagaactata acaggacatg      480

aaaggtgttc ttttttaaag tgttcagaac cctgtggaag tttcgtgcag tcttcagact      540

caaatcttcg tcttcacccc cggggcaagc tcagtgacta ttatatggtg ggtgtgtttc      600

cttaccagcg tgagtatgag tgcccagact tccccagcag agaagggcct gaatccgggg      660

ctgatgtgcc aggaaagtta cgcttgcagc gggactgatg aagctatctt tgagtgtgat      720

gagtgctgca gtctgcagtg tctccgctgc gaggaggagc tccatcggca ggagcgcctg      780

agaaaccatg agcggataag actcaaacct ggccatgtcc cttactgtga cctctgcaag      840

ggtctcagtg ggcatttacc aggtgttagg cagagggcaa tagtgaggtg ccagacctgc      900

aaaattaact tgtgcctgga gtgccagaag aggactcatt ctgggggtaa caaaaggaga      960

caccctgtta ctgtgtacaa tgtcagtaat ctccaggagt cactggaggc agaagagatg     1020

gatgaggaga ccaagaggaa gaagatgact gagaaggttg tgagtttcct cctagtagac     1080

gaaaatgaag aaattcaggt aacaaatgaa gaagacttta ttagaaaatt ggactgcaaa     1140

cctgatcagc atctgaaagt ggtttccatt tttggaaata ctggtgatgg aaagtctcat     1200

actctcaacc acactttctt ttatggtcgt gaagtcttta aaacctcccc gacccaggag     1260

tcctgcactg tgggagtgtg ggcagcctat gacccagttc acaaagtagc agtgatcgat     1320

acggaagggc tcctgggggc caccgtgaat ctaagccaga gaacacggct gctgcttaag     1380

gtcctggcca tctcagacct cgtcatctat cgaactcatg cagaccggct gcataacgac     1440

ctcttcaaat tccttgggga tgcctcagaa gcttatctga agcacttcac caaggagctc     1500

aaggccacca ctgctcgctg tggcctggat gtccctttat ccacactggg ccctgcagtt     1560

atcatcttcc atgagaccgt gcacacccag ctactgggct ctgatcatcc ctcagaggtg     1620

ccagagaagc tcatccagga ccggttccgg aagctgggcc gtttccctga agcctttagt     1680

tccattcact acaagggaac gaggacttac aaccctccca cggacttttc tgggcttcgg     1740

cgtgctttgg agcagctact agagaataac accacccgtt ctccccggca cccgggagtc     1800

atcttcaaag ccctgaaggc actaagtgac cgcttcagcg gtgagatccc cgatgaccag     1860

atggcgcaca gctccttttt tccagatgag tatttcacct gctcctcctt gtgcctcagc     1920

tgtggggttg gatgtaagaa aagcatgaat catgggaagg aaggagtgcc tcatgaagcc     1980

aagagccgct gcagatactc ccaccagtat gacaaccgag tgtatacctg caaggcctgc     2040

tatgagagag gcgaggaagt cagtgtagtg cccaaaacat ctgcttccac tgactccccc     2100

tggatgggtc tcgcaaaata tgcctggtct gggtatgtga tcgaatgtcc taactgtggc     2160

gtggtctatc gtagtcggca gtactggttt ggaaaccaag atcctgtgga tacggtggtg     2220

cggacagaga ttgtgcatgt gtggcctgga actgatgggt ttctgaagga caacaacaat     2280

gctgcccagc gcctgttgga cgggatgaac ttcatggctc agtcggtgtc cgagcttagc     2340

cttggaccca ccaaggctgt gacttcctgg ctgacagacc agatcgcccc tgcctactgg     2400

aggcccaact cccagattct gagctgcaac aagtgtgcga cgtcctttaa agataacgac     2460

actaagcatc actgccgagc ctgtggggag ggcttctgtg acagctgttc atcaaagact     2520

cggccagtgc ctgagcgggg ctggggccct gcgccagtgc gggtctgtga caactgctac     2580

gaagccagga acgtccagtt agctgttacc gaggcacaag tggacgatga aggtggaacg     2640

ctcattgctc ggaaggtggg cgaggccgtg cagaacactc tgggagccgt ggtgacagcc     2700

attgacatac cactaggtct ggtaaaggac gcggccaggc ctgcgtactg ggtgcctgac     2760

cacgaaatcc tccactgcca caactgccgg aaggagttca gcatcaagct ctccaagcac     2820

cactgccggg cctgcggaca gggcttctgt gatgagtgct cccatgaccg ccgggctgtt     2880

ccttctcgtg gctgggacca tcccgtccga gtctgcttca actgcaataa aaagcccgcc     2940

tggacatctc tgtctgtcat gactggaaag ggcccgttgt gctgaaatcc tatcatcatg     3000

gtggatttga tcttcagtgg ccaaacacga attaaagtat aattcttaac tgaactggtg     3060

ggtgggttga gctttaggga agtatatggc ggtcattcct ggtgcgccta tcggtgtgac     3120

atgagccctg gagtgtgtcg tccctctcag ccctgctcct cctgcctcct ggggtccagt     3180

gactgggacc ctactctaga actgtgtacc atccaattcg ccatcataaa ggaatcttcc     3240

tgca                                                                  3244


<210> 4572
<211> 2434
<212> DNA
<213> Homo sapiens

<400> 4572
ttggcgggga acgaaacaga gtgggtaacc attgccaata accttctttt taagtgtcat       60

atacatctga gaatacatga acttcaagac tgtgatgcta atgtttttat tgctctttat      120

cagtctattt tgggagaaaa ggtaccagac ctcatagtta ttcctaggag tcaagaagat      180

gatgcacaca atgtacaagc agtaattgat tcactggcct tggactactt gcaggtcagc      240

ttgtctcaca taacagctct atattctgtc tccaggagaa aatatagtga aaggagaatg      300

ttgggcccct cttgggatgg agatgaagca gaatccactg gtgaaatcat tagacttgga      360

gacacagcac acaccttttc tctaagaagt aatggtgctc aatgtcctaa tgaaatgctg      420

tctaaaaaag ccttagcctc accaagttct aaatcacatg aagatatgtt gtaccctcct      480

agtgttttgt ccaagagtag gacatccttt gttgaagaca cggaaaccct ttctgtgagt      540

gggattccaa atgctaggaa gctaggggag cctatccgag cagctattcc tttacatcca      600

ccctaccacc cttcagagcc tcgagcaccc tgccccatag gaaaagaata cttgcattca      660

agtcactgct ccccagccgt aaattctact ggagagcata cggaattttc tggggatcta      720

gatgatggac ttttcttaat ttccaagttg cctaaaggca gcaaatggga agtatatcca      780

gctcaggtcc aagggcctag gacaaggaag cctcccaaag gaaaaagaaa tgaaaacaga      840

gctacagcct catcctgcaa ttcacctttc ccccagaggc caagaaagag attaacagaa      900

caagaattac atgatgtatc agaaaaactc tctcagcggc tttctgaact agattggatg      960

ttaaaaagtg ctctgggtga tcggattaaa gaaaagactg accataaaga agaaaatact     1020

ggaaatgagg aggtagagga tggaactgag gagacactgt ctcagcacag tgatggcatc     1080

gtggagtatg ggccaaagaa gtcaaggcca ggactttcca tgcgtagaaa gccaccctac     1140

agatcccatt cgctctctcc atctccagtt aacaaacaca aacagttcca cttggagaga     1200

aaaaggcagc gcaagccaag agaaacagat gtccgccaat tccaagcaca ggcgtttact     1260

gaagcatttg aaagggaact aagaagacat aaagttcaag agaatattgg acctctaaga     1320

atacatgaga aggaggagga aacagtggga aaaaatatac agaggagaag cttcgtaaag     1380

gaactccaga atgtagtcag ccctggaaga tttactctag aaaaaccaca acgcagagtc     1440

agaggtggcc tcccaaagcc aaataaagca gttccaatga aagtaagtga acacagtctc     1500

ctgcccctta tgctggagca gtttccgttt ctttatgttt ctggcccaac actaagcaaa     1560

atgtggaaac agcaaattgc acaggttgaa cagcttaaga aagaagcatg tagagaaaat     1620

cgatcaaaga agaaactcca agatgaaata gaagaagccc taagaaggca tgacctcctt     1680

actacccttg tcaagaaaga atatgaacat aacaagagac tgcaagactt caaggactgc     1740

attcgtaggc aaaggttgac ccaatcaaag ataaaagaaa atcgacagca aatcgttcgt     1800

gctcgaaaat attatgatga ttatagagtt cagttgtgtg caaaaatgat gagaatgagg     1860

acccgggaag aaatgatatt taagaaactg tttgaagaag gtttaaacat tcaaaagcaa     1920

agattacgag acctaagaaa ctatgccaaa gaaaagcgag atgaacaaag gagacgccac     1980

caggatgaac tggactccat ggagaactac tataaggacc agttttcatt gctggcagaa     2040

gccatatcac aggaacatca agaacttaaa gccagagaga aatctcaggc ccagacatta     2100

cataaggtga agagggagct gagatctaag atggagaagg aaattcagca gctgcaggac     2160

atgataacac agaatgatga tgatgttttc ttccgggaac tggaagctga gcgcttcaga     2220

tctcggcttc agctggcttc ctttcagtac agtaaaagtc cctccctatg aggccagact     2280

tgataatagt aggtgaaggt tctggaggcc tttaccagga cagagctaga atcgagccag     2340

taaacagtct aagccagaaa aataattttc aaatgcttta cctgtatttt cattccagta     2400

ctttttatga ttttttaaat aaaaattgtt ttct                                 2434


<210> 4573
<211> 760
<212> DNA
<213> Homo sapiens

<400> 4573
agtcgcctcc ggaggaagga agaagaggac gccgggcgcg cagctcggtg ctgattatca       60

caactgtttg gtgacctact tcactgacct gtgaggattc cttcccttca gaatggaaac      120

agactgtaat cccatggagc taagcagtat gtcaggattt gaagaaggtt cagagctgaa      180

cggttttgaa ggaactgaca tgaaagacat gaggctcgaa gctgaagcag ttgtaaatga      240

tgttctcttt gctgttaaca acatgtttgt ctcgaaaagc ctgcggtgtg cggatgatgt      300

ggcctatatc aatgtggaaa caaaggaaag aaacagatat tgcctagaac tcactgaagc      360

agggctcaag gtggtaggct atgcttttga ccaggtagat gatcatttac agactcccta      420

ccatgaaaca gtctactcct tgttggatac actcagcccc gcctaccgag aagcatttgg      480

aaacgcactg cttcaaagac tggaagcttt gaaaagagat ggacagtcat gactacactt      540

tttcctttca gaggggctgg tgctggtaca gaatgttgat ataaagctta aaattcttgc      600

atatggtcat agaaaatgca tctttggttt tgtgttttta tcacttgctt ccaacttagg      660

cttttggctc agaagattat tgaataatga tttgtcttag tttctgtttc agtaagggaa      720

ttctgaggcc gttgctatga taccatcatt aagacattca                            760


<210> 4574
<211> 580
<212> DNA
<213> Homo sapiens

<400> 4574
tgaggggcga accaagatgg cggcggtttt ggctgtgtga ggaagacgga agagacggcg       60

gcggagggaa accgacttcc actagtccgg gtcgcttggg cggccggggg ccctcagagt      120

ctcccgggca gtggtagcag ttgcagcagg atcaggcgcc tgtcggcttc tgacgtttaa      180

aacaggggga gcggaaggga gccactggcc gcggtggcag ggccagggcc cctttcctgg      240

gcgtctactg gcggggcccc cgccccggtt cccgggcggc acgatgaccg acacccggcg      300

gcgggtgaag gtgtacacgc tcaacgagga ccggcagtgg gacgaccggg gcaccgggca      360

tgtgtcgtct ggctacgtgg agcggctgaa gggcatgtcc ctgcttgtca gggctgagag      420

cgacggttct ctacttttag agtcgaaaat aaatcctaac actgcatacc agaaacaaca      480

ggacactctg attgtgtggt ctgaagcaga aaattatgac ttggccctta gctttcaaga      540

aaaagctgga tgtgatgaaa tttgggagaa aatatgtcag                            580


<210> 4575
<211> 4108
<212> DNA
<213> Homo sapiens

<400> 4575
cgcctgtcgg cttctgacgt ttaaaacagg gggagcggaa gggagccact ggccgcggtg       60

gcagggccag gtataaggaa ggaaaatatg gcggcggcgg cggcggcctg aggaggcggc      120

ggcggcgcgg gaagctgctt cgcggagatc atggcggagg cgggagcagg gcagtgacgg      180

gagccccgag ttcctagcgc tgcggggcgg gaggctacga agcgctgcgc ggccccctcg      240

gggctgccgg gcgccgggct cgccaggcct ggacaatagc gccggggagc cggaggcgag      300

gaaaggcggc ggcccagagc tcggtccctg gagcgggcca tgcaggcggc ggcgcggccc      360

cgcggcgccc agcggcggca gtgaggccgg ggagccctcc gctcgcgggc gccctcacgc      420

ctcgcccctc gcctctccag ggcccctttc ctgggcgtct actggcgggg cccccgcccc      480

ggttcccggg cggcacgatg accgacaccc ggcggcgggt gaaggtgtac acgctcaacg      540

aggaccggca gtgggacgac cggggcaccg ggcatgtgtc gtctggctac gtggagcggc      600

tgaagggcat gtccctgctt gtcagggctg agagcgacgg ttctctactt ttagagtcga      660

aaataaatcc taacactgca taccagaaac aacaggacac tctgattgtg tggtctgaag      720

cagaaaatta tgacttggcc cttagctttc aagaaaaagc tggatgtgat gaaatttggg      780

agaaaatatg tcaggttcaa ggaaaggacc cttccgtgga catcactcag gaccttgtgg      840

atgaatctga agaggagcgt tttgatgata tgtcatcgcc aggcttagaa ttgccatctt      900

gtgaattaag tcgccttgaa gaaattgcag aacttgtggc atcatcttta ccttcacctc      960

ttcgtcgtga aaaacttgca ctggcactag aaaatgaggg ttatattaaa aagctcctgg     1020

agctttttca tgtgtgtgaa gatttggaaa atattgaagg actgcaccac ttgtatgaaa     1080

ttatcaaagg catctttctc ttgaatcgaa ctgctctttt tgaagttatg ttctctgaag     1140

aatgtataat ggacgtcatt ggatgtttag aatatgatcc tgctttatca caaccacgaa     1200

aacacaggga atttctaaca aaaacagcca agtttaaaga agtgattccc atatcagatc     1260

ctgagctgaa acaaaaaatt catcagacat acagagttca gtatatacaa gatatggttc     1320

taccaactcc ttcggtcttt gaagaaaaca tgttatcaac acttcactct tttatctttt     1380

tcaataaggt agagattgtt ggcatgttgc aggaagatga aaaatttctg acagatttgt     1440

ttgcacaact aacagatgaa gcaacagatg aggaaaaaag acaggaattg gttaactttt     1500

taaaagaatt ttgtgcgttt tcccaaacgc tacagcctca aaacagagat gcttttttca     1560

agactttgtc aaacatgggc atattaccag ctttagaagt catccttggc atggatgata     1620

cacaggtgcg aagtgctgct actgatatat tctcatactt ggttgaatat aatccatcca     1680

tggtacgaga gtttgtcatg caggaggcac aacagaatga tgatgatatt ttgctcatca     1740

acctcattat agaacatatg atttgtgata cagatcctga acttggagga gcagtccagc     1800

ttatgggcct gcttcgaact ttagttgacc cagagaacat gctagccact gccaataaaa     1860

cagaaaagac tgaatttctg ggtttcttct acaagcactg tatgcatgtt ctcactgctc     1920

ctttactagc aaatacaaca gaagacaaac ctagtaaaga tgattttcag actgcccaac     1980

tattggcact tgtattggaa ttgttaacat tttgtgtgga gcaccatacc taccacataa     2040

agaactacat tattaataag gatatcctcc ggagagtgct agttcttatg gcctcgaagc     2100

atgctttctt ggcattatgt gcccttcgtt ttaaaagaaa gattattgga ttaaaagatg     2160

agttttacaa ccgctacata atgaaaagtt ttttgtttga accagtagtg aaagcatttc     2220

tcaacaatgg atcccgctac aatctgatga actctgccat aatagagatg tttgaattta     2280

ttagagtgga agatataaaa tcattaactg ctcatgtaat tgaaaattac tggaaagcac     2340

tggaagatgt agattatgta cagacattta aaggattaaa actgagattt gaacaacaaa     2400

gagaaaggca agataatccc aaacttgaca gtatgcgttc cattttgagg aatcacagat     2460

atcgaagaga tgccagaaca ctagaagatg aagaagagat gtggtttaac acagatgaag     2520

atgacatgga agatggagaa gctgtagtgt ctccatctga caaaactaaa aatgatgatg     2580

atattatgga tccaataagt aaattcatgg aaaggaagaa attaaaagaa agtgaggaaa     2640

aggaagtgct tctgaaaaca aacctttctg gacggcagag cccaagtttc aagctttccc     2700

tgtccagtgg aacgaagact aacctcacca gccagtcatc tacaacaaat ctgcctggtt     2760

ctccgggatc acctggatcc ccaggatctc caggctctcc tggatccgta cctaaaaata     2820

catctcagac ggcagctatt actacaaagg gaggcctcgt gggtctggta gattatcctg     2880

atgatgatga agatgatgat gaggatgaag ataaggaaga tacgttacca ttgtcaaaga     2940

aagcaaaatt tgattcataa taatggcaac ggcctaggat cagtacctgt tgaaaaaaac     3000

tggttctcca cccctccccc atacaaaatc cacaacaaag cgcagtggtc tcttgtgaat     3060

gactgacaca gatcagcctc ttacacttga cttctgctca tcaagtgcca attcaatgga     3120

gcaggaggag gggatatcat atatttaggg gaaagactta agcctttgag ctctccagct     3180

tggaccacac attgcccttt tctcagggaa ggaaatggaa acaaaaagcc aacagggcag     3240

gggttttgta agtggaactc tggattgact ggtcagttgc tacaatcaga atatgctttc     3300

ttggaccatg tttgagactc agaagaatgg gcctttctgc cataattctt cactagtcaa     3360

gaatgccagc agtttctttg tataaagaga cctgccttta aaatcataca ttctgaacat     3420

tttagtcaag ctacaacagg tttggaaaac ctctgtgggg gaggggcgag tataaagttt     3480

tcctcttttt taactgttcc ctttgccctt caaactgcag atattttttt ttttaagtgg     3540

ggacttctcc ctacttgatt aaagattgag tggaattcta gatgtggtca tttgtgtcat     3600

aatttttttg ttttattttg tttttgattt tttttttcct cccctgagtg tatgcttagt     3660

tgttgagtat atatatttgg gaccattaaa actttttttg atgtaatata acctaacgtt     3720

gtgctggtac ctgttttacc atgtgtaatt tttgttctac atcacagttc ttaatttgtt     3780

tagagtttta tgaaagatgg tatagttttt attgacaaaa gcaaagtaat cttacaacta     3840

tgtgcataca aaagcaatac tattttgtga ctaaatattt tatattaaaa tttacatcag     3900

caactgtctt gagaattcag ggaaatagaa tggaatttaa aacttcaaca gttttgttaa     3960

atctagaaac atgaaattag tattccaaag agattctgaa atttcttttc ttggggaaat     4020

gacggtacat taaatcaaaa ttgaggatgg atgatttaaa aacatttgac ttttgaataa     4080

taaaaagaaa agtgaagagt aagagaaa                                        4108


<210> 4576
<211> 537
<212> DNA
<213> Homo sapiens

<400> 4576
aatagccaat agttatcttt tctgctcctc tccctcctcc caccctcctg cgtcagctaa       60

aaaacattcc cttcaattta aaaaatgttc ccgactctta acaccccagt tgagaactac      120

tgatcttaga tgtattaaag taaaatgaat gaaagtaaac ctggtgactc acagaacctt      180

gcttgtgttt tctgtcgaaa acatgatgac tgtcctaata aatacggaga aaagaaaact      240

aaggagaaat ggaatctcac tgtacattac tactgtttgt tgatgtcaag tggaatttgg      300

cagagaggca aagaagaaga aggagtttat ggttttctaa tagaagatat caggaaggaa      360

gtgaatagag cttctaaact gaaatgctgt gtttgcaaga aaaatggtgc ttcaattgga      420

tgtgttgcac cccgatgtaa acgaagttat catttcccat gtggacttca gagagaatgt      480

attttccagt ttactggcaa ttttgcgtca ttttgttggg accatcgacc tgttcaa         537


<210> 4577
<211> 9570
<212> DNA
<213> Homo sapiens

<400> 4577
ctgggcatcc acttgacagc cggcggcgct cgcggccctc agcatgttcc gcgaggcgag       60

ggttttcctc ccgcctgtgg gctgaggcgg cggcggcccc cgaaacgaga tgcacctgac      120

gggcgcggct tagaggacgc ggctggcggg aagtcccggc agccagcggg agggctttcg      180

ttgccgggcc gccgccgcct cccgtcgccg ccgcgggccc gagcgggagc ggcgggtggg      240

cgccccgaca tggcggcccg gagcgccccg agctgccacc tgcggctcga gtgggtgtac      300

ggctaccggg gccaccagtg ccgcaacaac ctctactaca ctgcggccaa ggagatcgta      360

tacttcgtgg cgggggtcgg cgtggtgtac agcccgcggg agcacaggca gaagttctac      420

cggggccaca gcgacgacat catcagcctt gcattgcatc ctgaacgagt gttggtagca      480

acaggacaag ttgggaaaga gccttatatt tgtatttggg attcatacac tgtgcagacc      540

atatcagttt taaaggatgt tcatacacat ggtatagctt gcttggcgtt tgacttagat      600

ggacagcgct tggtttcagt tggacttgat tcaaagaatg cagtttgtgt ttgggactgg      660

aaaaggggaa aaatgttgtc tatggctcct ggtcatacag atagaatatt tgatatttct      720

tgggatttgt accagccaaa taaacttgtc agctgtggtg taaaacatat caagttctgg      780

agtttatgtg gaaatgctct gaccccaaaa cgaggtgtct ttggtaagac gggtgacctt      840

cagacaatac tgtgcctagc ctgtgcaagg gatgaattaa catattctgg tgcactcaat      900

ggggatatat atgtttggaa aggaatcaat cttatacgaa caatacaagg agcccatgct      960

gcaggaattt ttagcatgaa tgcttgtgaa gaaggctttg ctactggtgg cagagatggt     1020

tgtattcgtc tttgggattt aacttttaaa ccaattactg tgattgatct cagggaaaca     1080

gaccagggat acaaaggttt gtctgtaagg agtgtgtgtt ggcgaggtga ccacattcta     1140

gttggaacac aggacagtga aatttttgaa attgtggtgc aagaaagaaa taaacctttt     1200

ctaattatgc aagggcattg tgaaggtgaa ctttgggcac ttgctgtcca tcctactaaa     1260

cctttggctg tgactggaag tgatgatcgt tcggtcagga tatggagcct agtagatcat     1320

gcattaatag caaggtgtaa tatggaagaa ccaattcgtt gtgcagctgt caatgcagat     1380

ggaatccatc ttgcccttgg aatgaaggat ggctcattca ctgtacttag agtaagagat     1440

atgacggaag ttgtacatat taaagatagg aaggaggcaa ttcatgagtt aaaatattca     1500

ccagatggaa cttaccttgc tgttggatgc aatgacagct cggttgatat ttatggagtt     1560

gctcagcgtt ataaaaaagt tggcgagtgt ttgggatccc ttagtttcat cactcatctg     1620

gactggtctt cagacagtag atatttgcag acaaatgatg gaaatgggaa aagacttttt     1680

tatagaatgc caggaggaaa ggaagtgaca agtacagaag aaataaaagg tgttcattgg     1740

gcttcatgga catgtgtttc aggccttgaa gtaaatggaa tttggcccaa gtattcagat     1800

atcaacgata taaattcagt agatggaaat tatattggcc aagttttagt tacagctgat     1860

gactatggaa ttataaaatt attccgatat ccatgtttaa gaaaaggggc caagtttaga     1920

aaatatattg gccattcagc tcacgtaact aatgtcagat ggtcacatga ttatcagtgg     1980

gttatttcta ttggtggagc agatcactct gtctttcagt ggaaatttat tcctgaaaga     2040

aaactgaaag atgctgttca catagcaccc caagaaagtc tggctgactc tcatagtgat     2100

gaatcagatt cagatctgtc tgatgttcca gaactggatt ctgaaattga acaagagaca     2160

cagctcacct accgtcgaca ggtttacaaa gaagatctac ctcagcttaa agaacagtgc     2220

aaagagaaac aaaaaagtgc tacttctaaa agaagagagc gggctccagg aaatagtatt     2280

cgattacact ttgttcacgg ttacagaggt tatgactgtc gaagtaatct gttttatact     2340

caaattggtg aaattgtgta ccatgtggca gcagtgggtg tcatttataa tcgacagcaa     2400

aacacacagc gtttttatct gggtcatgat gatgatattc tctgcctaac tattcatcct     2460

ttgaaagact acgtggcaac aggccaggtt ggtagagatc cctcaattca tatatgggat     2520

acagagacca ttaaaccatt gtccatatta aagggccacc accagtatgg tgttagtgcc     2580

gttgatttct cagcggatgg gaaacgtttg gcatcagttg gcatagatga tagccatact     2640

gttgtgctct gggactggaa gaaaggagag aaactttcaa tagcaagagg aagtaaagat     2700

aagatttttg ttgtaaagat gaacccctat gtgcctgata aactaattac agctggaatt     2760

aaacacatga aattttggcg taaagcaggg ggaggattga ttggaagaaa aggctacata     2820

ggcacactgg ggaaaaatga cacaatgatg tgtgcagtgt atggatggac tgaagagatg     2880

gctttttctg gaacatccac aggagatgtg tgtatctgga gagacatctt tcttgtaaaa     2940

acagtgaaag cgcatgatgg gccagtgttc agtatgcatg cattggaaaa agggtttgta     3000

actggaggaa aagatggtat agtagctctt tgggatgact cttttgaaag atgtctcaag     3060

acctatgcta taaaaagagc tgcattggcc ccaggatcta aaggtcttct cttggaagat     3120

aatccatcta tacgtgccat atcattagga catggtcata ttttagttgg cacaaagaat     3180

ggtgaaatac tagaagtgga taaaagtggc ccaataacac ttctggttca gggacacatg     3240

gaaggagagg tgtggggttt agctacacac ccttatctgc ccatctgtgc tactgtaagc     3300

gatgataaaa ccttaagaat atgggatctc tcacctagtc attgtatgtt ggctgtccgg     3360

aagctgaaaa agggtgggag gtgttgctgt ttttctcctg atggtaaagc tttagccgta     3420

ggtctcaacg atggaagctt cttaatggca aatgcggata ctctagagga tcttgtgtct     3480

tttcatcaca gaaaagatat gatttcagat attcgatttt cacctggttc tgggaaatat     3540

cttgctgtag catcccatga cagctttata gatatataca atgtaatgag tagtaaacga     3600

gtaggaatat gcaaaggagc taccagttac ataacccata ttgattggga tattagagga     3660

aagcttttac aggtcaacac tggtgctaag gaacaattat tctttgaagc tcccagaggg     3720

aaaaaacaaa ccatccccag cgtggaggta gaaaaaattg cttgggcatc atggacaagt     3780

gtacttggtt tatgctgtga aggaatttgg ccagtaattg gagaagttac agatgtaact     3840

gcttcttgcc tcaccagtga caaaatggtt ctagctaccg gggacgattt gggatttgtg     3900

aagttattta gatatcctac taaagggaaa tttggaaagt ttaagaggta tgtggcccat     3960

agtacacatg tcacaaatgt tcgctggact tatgatgaca gcatgttggt taccctaggc     4020

ggtacagata tgtctttaat ggtgtggaca aatgagatgg aaggctatcg agaaaaaagg     4080

ccttgtgata gtgaagaatc cgacattgat tctgaagaag atgggggcta tgacagtgat     4140

gttacaaggg agaatgaaat cagttacacc atcagagcct tatcaacaaa tattcgccca     4200

atgttaggaa tcaagcctca tttacaacaa aaagaaccct caattgatga aaggcaggga     4260

gtagtaagag gttccaggcc tccagtgagc agggccccac cacagccaga gaaactccag     4320

acaaacaatg taggcaagaa aaagagacct atagaggacc ttgtgttgga gctcattttt     4380

ggttatcgag gcagagactg taggaataat gttcactatt taaatgatgg tgatgatata     4440

atttatcaca ctgcatctgt tggaattctg cacaatgttg ctacaggttc tcagagtttt     4500

tatcaggaac ataatgatga tattctgtgc ctcacagtaa accagcaccc caaatttatc     4560

aacatagtgg caactggcca agtaggtgat tcagcagaca tgtcagctac agctccttct     4620

attcacatct gggatgcaat gaacaagcag actttatcta tcctaagatg ctaccattca     4680

aagggagtat gttcagtcag cttcagtgct actggcaaac tattgctgtc tgtgggacta     4740

gacccagaac atactattac catttggaga tggcaggaag gtgccaaaat tgccagcaga     4800

gctggtcaca atcaacgtat ttttgtggca gaattccgac cagattcaga tacccagttt     4860

gtctcagtgg gagtaaaaca tgtgaagttc tggaccctgg caggaagagc tcttcttagc     4920

aaaaaagggc tactgagcac actggaagat gcccggatgc agaccatgct cgctattgca     4980

tttggtgcaa ataacttgac gtttacaggt accatcagtg gtgatgtctg tgtgtggaaa     5040

gatcacatat tgtgtagaat cgtggcgaga gctcacaacg ggcctgtgtt tgccatgtac     5100

accaccctgc gagatggact tatcgtgact gggggaaagg aaaggccgtc aaaagaagga     5160

ggagcggtta aactgtggga tcaggaactg aggcggtgcc gtgccttcag gcttgagaca     5220

ggacaagcca cagattgtgt tcgttctgtg tgcagaggca aaggcaagat ccttgttggg     5280

acaaggaatg ctgaaataat cgaagttgga gagaaaaatg cagcttgtaa tattttagtt     5340

aacggtcatg tggatgggcc aatctgggga ctagcaacac atccttccag ggattttttc     5400

ctttctgctg cagaagatgg gacagtgaga ctttgggata ttgctgataa aaagatgtta     5460

aacaaagtga atttgggaca tgctgctcgt actgtgtgtt acagccctga aggggacatg     5520

gtggctattg gaatgaaaaa tggagaattt atcattttac tagtgagttc tctaaaaata     5580

tggggaaaga agagagacag gagatgtgca atccatgata tcagatttag tccggattcc     5640

cggtatctgg cagtaggttc tagtgagaac tcagtggatt tttatgacct aacgctgggc     5700

cccactctta acagaatcag ctactgcaaa gacattccaa gctttgtcat tcaaatggac     5760

ttctctgcag atagcagtta tctccaggtc tctagtggct gctataaacg gcatgtctat     5820

gaagtgcctt caggaaaaca tcttatggat catgccgcta ttgacagaat tacttgggct     5880

acatggacta gtattctagg agatgaggtt ttgggaatct ggtccagaca tgctgagaaa     5940

gctgatgtca actgtgcctg tgtatctcat tcaggaatca gtcttgttac aggagatgac     6000

tttggcatgg ttaagttatt tgacttccca tgtccagaaa aatttgcaaa acacaaaagg     6060

ttcttgggtc attcgcccca tgtgacaaat attcgattta ccagtggtga tcgacatgtt     6120

gttagtgctg gaggtgatga ctgcagctta tttgtctgga aatgtgtaca tacacctcac     6180

tgagagatgc tgagatgact acagaaatta actttgagac cagaattaca gagaagaaaa     6240

accaaaaccc aaccctgcat ggtcaagtgg tgctaaccca agactgtaac agggagaaat     6300

gcccagaatc atcaaaatag tgaaagactg atctgttcaa aatatttgct atatgcactg     6360

ggtataatcc gtaatccata cactgccaga taatgccatt tcaaggaagg atcgaatact     6420

tgatggtaaa ggccaagtcc ccctgtattg ggaagtgtgt gatttcggca gacctgctgg     6480

gaaaatttag ggtagagcac tctttacaga agaactcaaa aacccaattt ggataatttt     6540

cattatcttt ttagcaaaat ggtttcttaa tgtttatatt ttattttcaa ggttcattgt     6600

ttaatgaaat attttattct tgcatttcca taaggaaagg gaaagtcatg atcatcctaa     6660

aggatcacag tttttaaaag gcaaacattt tccctaagga aacagacaca agctttccta     6720

gagaatatga tgttttttag gcattaataa ggtccttttt tataaaggac acttttctcc     6780

tagtagtttt gaattcagga acagatccaa agttagcagt atatggctgc tacatttcca     6840

ttttcatttt cgagccatca gtttatgttc agatgccatc tctgtaatcg cacatttaaa     6900

acataactgt agcctcacta atggaaaagt agtatgatga acaatcattc ccaatggtgt     6960

acaatgtaag ggttttaggg agcaacagta tttaactgga agaaagaatt gcatatttaa     7020

tgtagtctaa tatatacaca tttgtttaac atgtaaacaa aagtgttaaa ttcacatata     7080

caacattata caatttaatc actcttggaa taaaattttt atagcctttt ttctattggg     7140

aaaatttgtt tagatgtgtg ccactccata ggtttatttc caaaatgaat gagcccaact     7200

ccatttgtaa aaacttgtca gttagaattc ctttttttag tggattaggg ctgaattctt     7260

agatccttat ttcttttcac tttaaatgct gccaaagatc actactcatc attcaggaat     7320

tcgctgtcta gcctatctgt agtttcctga agattgaaaa ttatgtagac tgctatttaa     7380

aaatatattt ttctaagtgt gaggtttaag atgctgtatt gaccctatga gtttttaatg     7440

tgttaattat ctttatagca taatagatcg ctttaggttc ctggaatccc atttggtctg     7500

acaggatata tgaagattct taatacctat tttctgtgtc taatacttgg ttaatactaa     7560

aaatagaaat gactaaatta catcacagaa agcataacca gtgattgaac ctggtagttt     7620

taaagctcta aatagctgtg gctgaaggac tgattatggg gctaagaagc ttgaaacgta     7680

agttggtact tgttcatcag tggattctcc taaattaagc caaattttga aatacatgac     7740

tattaagttt ctactcatgt atttacagtc agtcaataaa ttaaaggagg aaaaaaatcc     7800

ctgaacaacc tgcccataaa aagaaaaata ctctacattt gagcctgctg cagttttaaa     7860

ttttccctct gggtcaagtt tgccagcttt tggctacaga gaaattatat ttccattaca     7920

gtgcaggtag aaactctgta accttaagca tgtaaactac atagaataaa actgtttcca     7980

ctgcatttct gtccttcaaa gtggccaacc tgattaagtc agccttaatc actgctgctg     8040

tcagtttcac gactaaaggt catattgact aagtagtcat cagctgacca cctcgctgta     8100

tcagccagca acgaggggaa ggtgaagaaa catgataggc catatagaat ctgccctatg     8160

tttacttttt taacccagat aattattttt gtgtgcagta tctaagctcc tgattgtgta     8220

acctgggact tctggcacct tttgttccat tcattttatg tataaaatgc atgccaaagc     8280

acactgtgcc ctctggtacc cttgcttcca atcgccaacc atgctcattt ccttcctttt     8340

tttgtggtcc ctttttgtgg tgatcatttt aaaccacgtc atccaacaaa tgttttatgg     8400

tcaaccttag cttgttcata agccatagca actgaaagat taaactctta aatatgtgtc     8460

tgggcagtgg ctattaaata gcaaaaaaca atcagatttt agtattttat tatttccttg     8520

taaaatggct gaactaaatt aaacccttgt ttcccatttg ttctataatt tatagtgaaa     8580

ctgagaacaa aactatcttt ataaatgata gctaaaagta tttccagata tttaaacaat     8640

ttaaaataaa tttcttctgc agagatgcaa agcatctcaa cactggaatg aacaaatgcc     8700

ttaaattcaa tggagtaaac ctttagaatg aagaggaact gtcatttcac ccaagccgaa     8760

gacaacagcc ttatgcactt gtgtgctctg tctttgctgc ttctcgtgtt tcaagccttt     8820

cctgtgggat cagcacagca aagtgcaact taccaaatgg tttaatgact ggttaattct     8880

ttcttctccc aatggaaaag caatggcaac acaacagtag actgctggct tgacaatctt     8940

aaacgtgagc ctttgcacat gtaggtttat catcatttga gtatacgact aagcaagtca     9000

atgaactttt tttttttttt tagcagttta atttggtcct gagaatgttg cagtctttat     9060

tacccctttt gcattaatcc acttttctaa ccacctttta agctttaatt tttaacacta     9120

tacaccaagt ctttgaaatc agtgatctgt tatttaactc taaagcattt gacacttctt     9180

gccttaacag ttttaaaaac cacacacaaa aaaactctgt aagtaataca gtaggccaaa     9240

agtttcatcc tatctatctt gcagtttacc tatctgatct gatctctgta attatagttc     9300

tgtcatttaa aatatactat ttaaatctaa tttttacatt tcaaaaatta tcttcagtag     9360

taactaagta tattttctgt ggattctgag aatgttattt ttcagaatgt gagaatatat     9420

atgtacattt ataatcttgt gactttaaag tctgttttca gatacagtat gtaaatactt     9480

gtaaaaaaat ttgtataatt ttgtgataat gtagtttccc aaaaaaatta tttagaaggc     9540

attatgttat tagtaaatga gagcactgta                                      9570


<210> 4578
<211> 3369
<212> DNA
<213> Homo sapiens

<400> 4578
tgaggccggg gagccctccg ctcgcgggcg ccctcacgcc tcgcccctcg cctctccagg       60

gcccctttcc tgggcgtcta ctggcggggc ccccgccccg gttcccgggc ggcacgatga      120

ccgacacccg gcggcgggtg aaggtgtaca cgctcaacga ggaccggcag tgggacgacc      180

ggggcaccgg gcatgtgtcg tctggctacg tggagcggct gaagggcatg tccctgcttg      240

tcagggctga gagcgacggt tctctacttt tagagtcgaa aataaatcct aacactgcat      300

accagaaaca acaggacact ctgattgtgt ggtctgaagc agaaaattat gacttggccc      360

ttagctttca agaaaaagct ggatgtgatg aaatttggga gaaaatatgt caggttcaag      420

gaaaggaccc ttccgtggac atcactcagg accttgtgga tgaatctgaa gaggagcgtt      480

ttgatgatat gtcatcgcca ggcttagaat tgccatcttg tgaattaagt cgccttgaag      540

aaattgcaga acttgtggca tcatctttac cttcacctct tcgtcgtgaa aaacttgcac      600

tggcactaga aaatgagggt tatattaaaa agctcctgga gctttttcat gtgtgtgaag      660

atttggaaaa tattgaagga ctgcaccact tgtatgaaat tatcaaaggc atctttctct      720

tgaatcgaac tgctcttttt gaagttatgt tctctgaaga atgtataatg gacgtcattg      780

gatgtttaga atatgatcct gctttatcac aaccacgaaa acacagggaa tttctaacaa      840

aaacagccaa gtttaaagaa gtgattccca tatcagatcc tgagctgaaa caaaaaattc      900

atcagacata cagagttcag tatatacaag atatggttct accaactcct tcggtctttg      960

aagaaaacat gttatcaaca cttcactctt ttatcttttt caataaggta gagattgttg     1020

gcatgttgca ggaagatgaa aaatttctga cagatttgtt tgcacaacta acagatgaag     1080

caacagatga ggaaaaaaga caggaattgg ttaacttttt aaaagaattt tgtgcgtttt     1140

cccaaacgct acagcctcaa aacagagatg cttttttcaa gactttgtca aacatgggca     1200

tattaccagc tttagaagtc atccttggca tggatgatac acaggtgcga agtgctgcta     1260

ctgatatatt ctcatacttg gttgaatata atccatccat ggtacgagag tttgtcatgc     1320

aggaggcaca acagaatgat gatgtaagta agaagttaac agagcaaaaa ataaccagca     1380

aggatatttt gctcatcaac ctcattatag aacatatgat ttgtgataca gatcctgaac     1440

ttggaggagc agtccagctt atgggcctgc ttcgaacttt agttgaccca gagaacatgc     1500

tagccactgc caataaaaca gaaaagactg aatttctggg tttcttctac aagcactgta     1560

tgcatgttct cactgctcct ttactagcaa atacaacaga agacaaacct agtaaagatg     1620

attttcagac tgcccaacta ttggcacttg tattggaatt gttaacattt tgtgtggagc     1680

accataccta ccacataaag aactacatta ttaataagga tatcctccgg agagtgctag     1740

ttcttatggc ctcgaagcat gctttcttgg cattatgtgc ccttcgtttt aaaagaaaga     1800

ttattggatt aaaagatgag ttttacaacc gctacataat gaaaagtttt ttgtttgaac     1860

cagtagtgaa agcatttctc aacaatggat cccgctacaa tctgatgaac tctgccataa     1920

tagagatgtt tgaatttatt agagtggaag atataaaatc attaactgct catgtaattg     1980

aaaattactg gaaagcactg gaagatgtag attatgtaca gacatttaaa ggattaaaac     2040

tgagatttga acaacaaaga gaaaggcaag ataatcccaa acttgacagt atgcgttcca     2100

ttttgaggaa tcacagatat cgaagagatg ccagaacact agaagatgaa gaagagatgt     2160

ggtttaacac agatgaagat gacatggaag atggagaagc tgtagtgtct ccatctgaca     2220

aaactaaaaa tgatgatgat attatggatc caataagtaa attcatggaa aggaagaaat     2280

taaaagaaag tgaggaaaag gaagtgcttc tgaaaacaaa cctttctgga cggcagagcc     2340

caagtttcaa gctttccctg tccagtggaa cgaagactaa cctcaccagc cagtcatcta     2400

caacaaatct gcctggttct ccgggatcac ctggatcccc aggatctcca ggctctcctg     2460

gatccgtacc taaaaataca tctcagacgg cagctattac tacaaaggga ggcctcgtgg     2520

gtctggtaga ttatcctgat gatgatgaag atgatgatga ggatgaagat aaggaagata     2580

cgttaccatt gtcaaagaaa gcaaaatttg attcataata atggcaacgg cctaggatca     2640

gtacctgttg aaaaaaactg gttctccacc cctcccccat acaaaatcca caacaaagcg     2700

cagtggtctc ttgtgaatga ctgacacaga tcagcctctt acacttgact tctgctcatc     2760

aagtgccaat tcaatggagc aggaggaggg gatatcatat atttagggga aagacttaag     2820

cctttgagct ctccagcttg gaccacacat tgcccttttc tcagggaagg aaatggaaac     2880

aaaaagccaa cagggcaggg gttttgtaag tggaactctg gattgactgg tcagttgcta     2940

caatcagaat atgctttctt ggaccatgtt tgagactcag aagaatgggc ctttctgcca     3000

taattcttca ctagtcaaga atgccagcag tttctttgta taaagagacc tgcctttaaa     3060

atcatacatt ctgaacattt tagtcaagct acaacaggtt tggaaaacct ctgtggggga     3120

ggggcgagta taaagttttc ctctttttta actgttccct ttgcccttca aactgcagat     3180

attttttttt ttaagtgggg acttctccct acttgattaa agattgagtg gaattctaga     3240

tgtggtcatt tgtgtcataa tttttttgtt ttattttgtt tttgattttt tttttcctcc     3300

cctgagtgta tgcttagttg ttgagtatat atatttggga ccattaaaac tttttttgat     3360

gtaatataa                                                             3369


<210> 4579
<211> 4173
<212> DNA
<213> Homo sapiens

<400> 4579
tcgattcaaa gcttcggcaa gacgaagaaa accgagcctg aaagcagggc gagaaaaggg       60

gcgctgcagg gcggatggaa agaattgatt ggtaacgatg tggagacgga aacatccgag      120

gacatccgga ggaacccggg gagttctgag tggtaatcga ggggtagagt atggcagtgg      180

gcggggtcat ctcggtacgt tcgaagggcg ttggcggaaa ttaccgaaga tgcccgaagc      240

cgtcgggacg gacccgagta cctcacgcaa gatggcggag ctggaggagg tgactctgga      300

cgggaagcct cttcaggcgc tgcgggtgac cgacctgaag gccgcactgg agcagcgagg      360

cctagccaag agcgggcaga agagtgccct ggtcaagcgg ctcaaagggg ctctaatgct      420

agaaaattta cagaaacact caacacccca tgctgcattc cagccaaatt cccagattgg      480

tgaggaaatg agccagaaca gtttcataaa acagtatctg gaaaagcagc aggagctact      540

taggcagcgt ctggaacgtg aagctcgaga agctgcagaa cttgaagaag cttcagctga      600

gtcggaggac gagatgatcc atcctgaggg agtggcttcc ctgctgcctc ctgactttca      660

gagcagcctg gagagaccag agctggagct cagcagacat tcgcccagaa aaagctcctc      720

aatttctgaa gagaaaggtg actctgatga tgagaaacca aggaaaggag aaagacgatc      780

atctagggtc agacaggcaa gagcagctaa actgtctgag ggcagccaac ctgctgagga      840

ggaagaggat caagaaacac cttccagaaa cctaagggtc agagcagatc gaaatttgaa      900

aacagaggag gaagaagagg aggaggagga ggaggaagaa gatgatgaag aagaggaagg      960

tgatgatgag ggacaaaaat ctagggaggc accaatcctg aaagagttta aggaagaagg     1020

ggaagagata cctagagtaa aaccagagga gatgatggat gagagaccca aaacaagatc     1080

ccaggaacag gaggtgttag agagaggagg gagatttaca agatcccagg aagaggctag     1140

aaaaagtcat ctggccagac agcagcagga gaaggaaatg aaaacaacat ctccccttga     1200

ggaggaagaa agagaaataa aatcttcaca aggcttaaag gaaaaatcga agtctccttc     1260

ccctcctcga ctgactgaag atcgaaagaa ggcctcactt gtagcgctgc cagagcaaac     1320

tgccagcgag gaggagactc ctccaccttt actaacaaag gaagcatctt ctccaccacc     1380

tcatccacag ctccatagcg aagaagaaat agagcccatg gaaggcccag cccccgctgt     1440

cctcattcag ttatctcctc ctaatacaga tgctgacacc agggagctat tagtatctca     1500

gcatactgtc cagttggtag gaggcctgtc tcctttgtca agtccttcag acaccaaagc     1560

agaatctcca gcagagaaag tgccagagga gagtgtcctg cctctggttc agaaaagcac     1620

actggctgac tactcagccc agaaggatct tgaacctgag tcagacagat ctgctcagcc     1680

cctccctcta aaaattgagg aattagcact ggccaaagga atcactgaag aatgtctgaa     1740

acagccatct ttggaacaga aggaaggcag aagagcttct catacccttc tcccaagcca     1800

cagattgaaa cagtcagctg attcatcctc tagccggtcc tcctcatctt cctcctccag     1860

ttctagatca agatctcgct ctcctgacag ttcaggttct cggtctcatt caccgctcag     1920

atccaagcag agagatgtag cccaggcacg tactcatgcc aaccctcgtg gtagacccaa     1980

gatgggctcc agatcaacat cagagtccag atcaaggtca cgttcacgtt ctcgttcagc     2040

atcaagcaac agcagaaaat ctctgagccc tggagtctcc agggacagca gcaccagcta     2100

tactgaaacc aaagatccct cttctggtca ggaggttgca actccaccag tgccacaact     2160

gcaggtctgt gagccaaagg agaggacttc cacctcctca tcctctgtcc aagcaaggcg     2220

tctgagtcag cctgaatcag ctgaaaagca tgtgacccag aggttacagc ctgagcgggg     2280

gagcccaaag aagtgtgaag ctgaagaggc agagccacca gctgccacac agccccaaac     2340

ctcagagact cagacctctc atctgccaga atcagaaaga attcatcaca ctgttgagga     2400

gaaggaggaa gtgaccatgg acacaagtga aaacagacct gaaaatgatg ttccagaacc     2460

tcccatgcct attgcagacc aagtcagcaa tgatgaccgc ccggagggca gtgttgaaga     2520

tgaggagaag aaagagagct cgctgcccaa atcattcaag aggaagatct ccgttgtctc     2580

taccaagggg gtgccagctg gaaacagtga cacagagggg ggccagcctg gtcggaaacg     2640

acgctgggga gccagcacag ccaccacaca gaagaaacct tccatcagta tcaccactga     2700

atcactaaag gaggctgttg tggatcttca tgctgatgac tctcgcatct ctgaggatga     2760

gacagagcgt aatggcgatg atgggaccca tgacaagggg ctgaaaatat gccggacagt     2820

cactcaggta gtacctgcag agggccagga gaatgggcag agggaagaag aggaagaaga     2880

gaaggaacct gaagcagaac ctcctgtacc tccccaggtg tcagtagagg tggccttgcc     2940

cccacctgca gagcatgaag taaagaaagt gactttagga gataccttaa ctcgacgttc     3000

cattagccag cagaagtccg gagtttccat taccattgat gacccagtcc gaactgccca     3060

ggtgccctcc ccaccccggg gcaagattag caacattgtc catatctcca atttggtccg     3120

tcctttcact ttaggccagc taaaggagtt gttggggcgc acaggaacct tggtggaaga     3180

ggccttctgg attgacaaga tcaaatctca ttgctttgta acgtactcaa cagtagagga     3240

agctgttgcc acccgcacag ctctgcacgg ggtcaaatgg ccccagtcca atcccaaatt     3300

cctttgtgct gactatgccg agcaagatga gctggattat caccgaggcc tcttggtgga     3360

ccgtccctct gaaactaaga cagaggagca gggaatacca cggcccctgc accccccacc     3420

cccacccccg gtccagccac cacagcaccc ccgggcagag cagcgggagc aggaacgggc     3480

agtgcgggaa cagtgggcag aacgggaacg ggaaatggag cggcgggagc ggactcgatc     3540

agagcgtgaa tgggatcggg acaaagttcg agaagggccc cgttcccgat caaggtcccg     3600

tgaccgccgc cgcaaggaac gtgcgaagtc taaagaaaag aagagtgaga agaaagagaa     3660

agcccaggag gaaccacctg ccaagctgct ggatgacctt ttccgaaaga ccaaggcagc     3720

tccctgcatc tattggctcc cactgactga cagccagatc gttcagaaag aggcagagcg     3780

ggccgaacgg gccaaggagc gggagaagcg gcgaaaggag caagaagaag aagagcaaaa     3840

ggagcgggag aaggaagccg agcgggaacg gaaccgacag ctggagcgag agaaacgtcg     3900

ggagcacagt cgggagaggg acagggagag agagagagaa agggagcggg acagggggga     3960

ccgagatcgg gatagggaaa gggaccgaga acgaggcagg gaaagggatc gcagggacac     4020

caagcgccac agcagaagcc ggagtcggag cacacctgtg cgggaccggg gtgggcgccg     4080

ctagctggga aaacactaga gctgcaggta ccagccactc ggccccaggg ggttatggcc     4140

acagagggat aggcacagtc tccaccaccc tgg                                  4173


<210> 4580
<211> 1225
<212> DNA
<213> Homo sapiens

<400> 4580
ctttcttggg gtaggtgggc ccttccctgc ctttctcttc tagctttggg atctcaggag       60

gaggagaacc caagaaactg tggaatgatg tgaggcacta agtgaccgct tcagcggtga      120

gatccccgat gaccagatgg cgcacagctc cttttttcca gatgagtatt tcacctgctc      180

ctccttgtgc ctcagctgtg gggttggatg taagaaaagc atgaatcatg ggaaggaagg      240

agtgcctcat gaagccaaga gccgctgcag atactcccac cagtatgaca accgagtgta      300

tacctgcaag gcctgctatg agagaggcga ggaagtcagt gtagtgccca aaacatctgc      360

ttccactgac tccccctgga tgggtctcgc aaaatatgcc tggtctgggt atgtgatcga      420

atgtcctaac tgtggcgtgg tctatcgtag tcggcagtac tggtttggaa accaagatcc      480

tgtggatacg gtggtgcgga cagagattgt gcatgtgtgg cctggaactg atgggtttct      540

gaaggacaac aacaatgctg cccagcgcct gttggacggg atgaacttca tggctcagtc      600

ggtgtccgag cttagccttg gacccaccaa ggctgtgact tcctggctga cagaccagat      660

cgcccctgcc tactggaggc ccaactccca gattctgagc tgcaacaagt gtgcgacgtc      720

ctttaaagat aacgacacta agcatcactg ccgagcctgt ggggagggct tctgtgacag      780

ctgttcatca aagactcggc cagtgcctga gcggggctgg ggccctgcgc cagtgcgggt      840

ctgtgacaac tgctacgaag ccaggaacgt ccagttagct gttaccgagg cacaagtgga      900

cgatgaaggt ggaacgctca ttgctcggaa ggtgggcgag gccgtgcaga acactctggg      960

agccgtggtg acagccattg acataccact aggtctggta aaggacgcgg ccaggcctgc     1020

gtactgggtg cctgaccacg aaatcctcca ctgccacaac tgccggaagg agttcagcat     1080

caagctctcc aagcaccact gccgggcctg cggacagggc ttctgtgatg agtgctccca     1140

tgaccgccgg gctgttcctt ctcgtggctg ggaccatccc gtccgagtct gcttcaactg     1200

caataaaaag cccggtgacc tttaa                                           1225


<210> 4581
<211> 2218
<212> DNA
<213> Homo sapiens

<400> 4581
ggggcggaag aaggcgggga gggagggggc ggcaccgccg gtcggctcca gtcgcctccg       60

gaggaaggaa gaagaggacg ccgggcgcgc agctcggtgc tgattatcac aactgtttgg      120

tgacctactt cactgacctg tgaggattcc ttcccttcag gtactggatt cttgatcttt      180

ctgcatcatc aagaatggaa acagactgta atcccatgga gctaagcagt atgtcaggat      240

ttgaagaagg ttcagagctg aacggttttg aaggaactga catgaaagac atgaggctcg      300

aagctgaagc agttgtaaat gatgttctct ttgctgttaa caacatgttt gtctcgaaaa      360

gcctgcggtg tgcggatgat gtggcctata tcaatgtgga aacaaaggaa agaaacagat      420

attgcctaga actcactgaa gcagggctca aggtggtagg ctatgctttt gaccaggtag      480

atgatcattt acagactccc taccatgaaa cagtctactc cttgttggat acactcagcc      540

ccgcctaccg agaagcattt ggaaacgcac tgcttcaaag actggaagct ttgaaaagag      600

atggacagtc atgactacac tttttccttt cagaggggct ggtgctggta cagaatgttg      660

atataaagct taaaattctt gcatatggtc atagaaaatg catctttggt tttgtgtttt      720

tatcacttgc ttccaactta ggcttttggc tcagaagatt attgaataat gatttgtctt      780

agtttctgtt tcagtaaggg aattctgagg ccgttgctat gataccatca ttaagacatt      840

cacatgtctt catataatat ctcttcattt caaatcctaa tcactatttc atactattac      900

agggctttga tgctgccagc actgtctttt acataggaaa ttctagattt gcacagtaat      960

agaggaatta gaagtaccta actatacact ttgattcagc ctgctaaatc aggggttcaa     1020

tactagcttg gacaaacttt gtagtaatta attgctacca gccttattgg aaacaaatta     1080

tcaactagtt tcccctgcac aaattttgaa attcactgct tcacttaatc tatttatatt     1140

actaataatg gattaataaa gatgaattaa ttatatatta cttaactagt attaaatgaa     1200

aaacagggac tgaaatagtt ctgtattccg tgtttgcaac agccagccaa ctaagcagag     1260

gataaaccgt tagcaaatga atgtaataat tactcatttc caagatatct aagcacataa     1320

gcaaatacag gaacagactt cattcttttt cttaacaaaa aagcatcttc agtgtgtgat     1380

ttaaaagaaa gaagattctg gtttcctaga aaacaatatt ttggcctgtg ttgattctta     1440

ttctgaatgt gtgtttacat aatgtacagt atatattcag aaagtatttt tgcttcaacg     1500

tttactttct atgatgtagt gctttggtat tcctacagca ccccaccttc cccaacagat     1560

gtacagtgtt ctgtctccat tcgaaatcta caatgtaata tgagtgcatt gtatgggttt     1620

gaaaccaaag gatgaatgaa gcattcagag acttaatatt tgaaaaagga atagtcagta     1680

ttttatattt tattacaggt actgatattt ataaatttaa taaactgtac catgctgctg     1740

catgttttca agtacatgtt gaacagtaag gattggggag ttgtttttta atggtcacct     1800

aaagcagctg ctatagaaat gttgaactaa aattttgcat ctggtcatac cttcatgcat     1860

ttatcatttg cagatatttt tccatcatta ttaaaaaaca ggaactttta ggctctgaag     1920

atcatgtgga ccagagcaaa ttaaagttca gtttgtgtca caattcattg ccagacttca     1980

ttggaatgct ttgtttgatg atgtatgttc attctcagct ttattttcag atgcttaact     2040

gggcaacgaa gtctaacttc aggttgaact ttctcatgtt taatctcagg ctaaatgtaa     2100

atgatatttg taaagtttga ataaaattct gtttactcat tttgagttag tatgaaaaaa     2160

agtgattgta tgtttaagaa ttgaaattgt tcattttgtg ataaatgatt aattccaa       2218


<210> 4582
<211> 2635
<212> DNA
<213> Homo sapiens

<400> 4582
agcaagatgg ccgccgctga ggaaggctgt agtgtcgggg ccgaagcgga cagggaattg       60

gaggagcttc tggaaagatg ccctcttcgc ttcccaagag aagtttttcc aggaactatt      120

cgacagtgaa ctggcttccc aagccactgc ggagttcgag aaggcaatga aggagttggc      180

tgaggaagaa ccccacctgg tggagcagtt ccaaaagctc tcagaggctg cagggagagt      240

ggaactccag catgtcggaa gaagagctga ccaaggccat ggaggggcta ggcatggacg      300

aaggggatgg ggaagggaac atcctcccca tcatgcagag tattatgcag aacctactct      360

ccaaggatgt gctgtaccca tcactgaagg agatcacaga aaagtatcca gaatggttgc      420

agagtcatcg ggaatctcta cctccagagc agtttgaaaa atatcaggag cagcacagcg      480

tcatgtgcaa aatatgtgag cagtttgagg cagagacccc cacagacagt gaaaccactc      540

aaaaggctcg ttttgagatg gtgctggatc ttatgcagca gctacaagat ttaggccatc      600

ctccaaaaga gctggctgga gagatgctga cgtggctttt tttctgtggc tcccagtggg      660

tctacggacc ttggctgaca tatgttggct ggctacagca aacatcattc aagatgtcca      720

gcaaagggag cagcacagat ggcagaacag acttagctaa tggaagcctg tctagcagtc      780

cagaggagat gtctggagct gaagagggga gggagacatc ctcaggcatt gaagtggagg      840

cctcagacct gagtttgagc ttgactgggg atgatggtgg ccccaaccgc accagcacag      900

aaagtcgagg cacagacaca gagagctcag gtgaagataa ggactctgac agcatggagg      960

acactggtca ttactccatt aatgatgaaa atcgagtcca tgaccgctca gaggaagagg     1020

aagaggagga agaagaggag gaagaagagc agcctcggcg ccgtgtacag cgcaagcggg     1080

ctaaccgtga ccaggactca tcagatgatg agcgggccct agaggactgg gtgtcctcag     1140

aaacatcagc tctaccccga cctcgctggc aagccctccc tgcccttcgg gagcgggagc     1200

tgggttcaag tgcccgcttt gtctatgagg cctgtggggc aagagtcttt gtgcagcgtt     1260

tccgcctgca gcatgggctt gagggccata ctggttgtgt caataccctg cactttaacc     1320

agcgcggcac ctggctggcc agtggcagcg atgacctgaa ggtggtggtg tgggattggg     1380

tacggcggca gccagtactg gactttgaga gtggccacaa aagtaatgtg ttccaggcca     1440

agtttcttcc taacagtggt gattctactc tggccatgtg tgcccgtgac gggcaggttc     1500

gagtagcaga actgtctgcc acacagtgtt gcaagaatac aaaacgtgtg gcccagcaca     1560

agggagcgtc ccacaagttg gcactggaac cagactctcc ctgtacgttc ttatctgcag     1620

gtgaagatgc agttgttttc accattgacc tgagacaaga ccgcccagcg tcgaaactgg     1680

tggtgacaaa agagaaagag aagaaagtgg ggctgtatac gatctatgtg aatcctgcca     1740

atacccacca gtttgcagtg ggtggacgag atcagtttgt aaggatttat gaccagagga     1800

aaattgatga gaatgagaac aatggagtac tcaagaagtt ctgtcctcat cacctggtga     1860

acagtgagtc caaagcaaac atcacctgtc ttgtgtacag ccacgacggc acagagctcc     1920

tggccagtta caatgatgaa gacatttacc tcttcaactc ctctcacagt gatggggccc     1980

agtatgttaa gagatacaag ggccacagaa ataatgccac agtaaaaggc gtcaatttct     2040

atggccccaa gagtgagttt gtggtgagcg gtagtgactg tgggcacatc ttcctctggg     2100

agaaatcatc ctgccagatt attcagttca tggaggggga caagggaggc gtggtaaact     2160

gtcttgagcc ccaccctcac ctgcctgtgc tggcaaccag tggcctagac catgatgtga     2220

agatctgggc acccacagct gaagcttcca ctgagctgac agggttaaaa gatgtgatta     2280

agaagaacaa gcgggagcgg gatgaagata gcttgcacca aactgacctg tttgatagtc     2340

acatgctgtg gttccttatg catcacctga gacagagacg ccatcaccgg cgctggcgag     2400

aacctggggt tggggccaca gacgcggact ctgatgagtc tcccagctcc tcagacacat     2460

cggacgagga ggagggccct gaccgggtgc agtgcatgcc atcttgaggc ctcataccta     2520

ggtggggcag gctggggctg ccaacctgat cctgcctggg caaccctttc ctgtcccagg     2580

ccctacattc agcagaaacg cactttggac tttttgcttt agataaaaga aagac          2635


<210> 4583
<211> 2543
<212> DNA
<213> Homo sapiens

<400> 4583
ctgcggtcag agggccgagg cctgggggcg agctggggtc gtgcagtaca gcctctttcc       60

ggcaaatcac gcgagatttc gttcacccgg gctccacagg gtcagtgacg cgcgagcggc      120

tcccgcgact gtggctcccg aagctgcttc gggccccagc ggagtatttt atacagaaat      180

cttgtgaaac cactgcccaa ccagagcaat gattgttcaa agagtggtat tgaattctcg      240

acctggaaaa aatggtaatc cagtggcaga gaatttccga atggaagaag tctatttacc      300

agataatatt aatgaaggac aagtacaagt tagaactctt tatctttctg tggatcctta      360

catgcgttgt agaatgaatg aagacactgg cactgattat ataacacctt ggcagctatc      420

tcaagtcgtt gatggaggag gtattggaat tatagaagaa agcaaacaca caaatttgac      480

taaaggcgat tttgtgactt ctttctattg gccctggcaa accaaggtta ttctggatgg      540

aaatagcctt gaaaaggtag acccacaact tgtggatgga cacctttcat attttcttgg      600

agctataggt atgcctggtt tgacttcctt gattgggata caggaaaaag gtcatataac      660

tgctggatct aataagacaa tggttgtcag tggggccgca ggtgcctgtg gatctgtggc      720

tgggcagatt ggccatttct taggttgttc cagagtggtg ggaatttgtg gaacacatga      780

gaaatgcatc ctcttgacct cagaactggg ctttgatgct gcaattaatt ataaaaaaga      840

caatgtggca gaacagctcc gtgaatcatg cccagctgga gtggatgttt attttgacaa      900

tgttggtggt aacatcagtg atacagtgat aagtcagatg aatgagaaca gccacatcat      960

cctgtgtggt caaatttctc agtacaacaa agatgtgcct tatcctcccc cgctatcccc     1020

tgctatagag gcaatccaga aagaaagaaa catcacaagg gaaagatttc tggtattaaa     1080

ttataaagac aaatttgagc ctggcattct acagctgagt cagtggttta aagaaggaaa     1140

gctaaagatt aaagagacgg taataaatgg gttggaaaac atgggagctg cattccagtc     1200

catgatgaca ggaggtaaca ttggaaagca gatagtttgc atttcagaag aaatctcttt     1260

gtaattgctg taaatgtcat caaggcaatc atagatttct tttccatttt gcatattttc     1320

aaagatatgt taaaaaatcc ttagactata catagctctt gatttaaatg tgatcatagg     1380

tgttattttt agttgcatag ggtatttgat acaatcatta atggatcata cacaataggt     1440

ttttaaaaat taataacttt tagtaattac ttttattaat ttaaaataga acgcttgaga     1500

ggcactttgt aaagatttgt taaactggaa acgttttaca tgatctgata caaccattaa     1560

tgaatcatac acaataggtt ttttaaaatt aatattaata acttttatta atttaaaata     1620

gaatgcttaa aataaaatag aatgcttgag aggcactgag taaagatttg ttgaactgga     1680

aatgttttac atgattctta aactgaaact tggtgtaaaa atagaattga gatggccttt     1740

ttttcacatt gtagactgaa aagagactta atggtatgat gtgtacatag ggactggggg     1800

caggattggg ggtttcggag cttgtgtaac agtttttggg ataggagacc agcggttttg     1860

ggttgggatt agtatgggaa gataaataac ttaggttggt taagttgaca agatttactc     1920

cagaggatca tctctttgta tttgccaaat aatttactgt atagcctaaa aactccatat     1980

atattgagaa aagcatatgt ttattttagg ttagcaggca catactgtca agttgtaaag     2040

attgagaggg caaacagatg taaacatcac ttgtaggtga ttaaaaagat tgacagccgg     2100

gcctgatgtc tcaagcctgt aatcctagca ctttgggagg cagaggcggg cagatcactt     2160

gaggtcagga gttcaagacc agcctggcca acacggtgaa accccatctc tctaaaaata     2220

caaaaattag ctgggcgtgg tggcacacgc ctgtaatccc agctactcag gaggctgagg     2280

ctggagaatc atttgaacct gggaggggga ggttgccgtg agctgagctt gcaccattgc     2340

actccagcct gggcgacaag agtgaaattc catctcaaaa aacaaaaaca gattgacaac     2400

aaagacagtt tcagaaaatg acaggactgg gcaaattaac aaatgtttgt aaacatgaat     2460

gttcaggaac tactgatgta cctcaaaagt ttgttttatt aattgtactc aaccctcgca     2520

gaacagtaaa actgaagatt att                                             2543


<210> 4584
<211> 1014
<212> DNA
<213> Homo sapiens

<400> 4584
ttcccaaggg gaggacgcgg gagaagccgg ggcctgagtg ctccaaggcc ccgtgggctt       60

cttgggtttg ttgcctccgg ccgctcatta actcaggatg gcgtggaaga cctcgcccgc      120

ctccccttct gggccgcggc tccgcttagg tgaaggcctg tttgggcgtc cccaccctgg      180

agaggggccg gggtctggat tttcagaact gccactcttc tagtgcgctg gcgtcaatgc      240

tcccttcctc gggccattgg agactccgtt gctttttaat ggcggcagcg gctgctgggt      300

gagcagctgg aggccggaca gtgttcgtcc catccggaga ggatcgcttt ctcctggcgt      360

caccagcgct gggttggtgg gggtagcttt tccctctttg ctcctccatt cttgaagaaa      420

gaagaagatg ccactgccat ttgggttgaa actgaaacgc acccggcgct acacggtgtc      480

cagcaagagt tgcctggttg cccggatcca actgcttaat aacgagtttg tggagttcac      540

cctgtccgtg gagagcactg gccaggaaag cctcgaggcc gtggcccaga ggctggagct      600

gcgggaggtc acttacttca gcctctggta ctacaacaag caaaatcagc gccggtgggt      660

agatttggaa aaacctttga agaagcagct ggataaatat gcattggaac ctaccgtcta      720

ttttggagtg gtgttttatg tgccttcagt ttctcagctg cagcaggaga ttaccaggta      780

tcagtattat ctgcaactga agaaagatat cttggaagga agtattcctt gtaccttaga      840

acaagcaatt cagctagcag gcttagctgt tcaagcggat tttggtgact ttgatcagta      900

tgaatcccag gactttcttc agaaatttgc cttgtttcct gtgggatggt tacaagatga      960

aaaagtattg gaagaagcaa cccaaaaagt ggccttacta catcagaaat acag           1014


<210> 4585
<211> 5095
<212> DNA
<213> Homo sapiens

<400> 4585
agctggaggc tgcgtgggat ccggcggcgg ctcccgagcg cggcggtgcg gccttccccg       60

ccccctccct ccctcctccc ccgcccgctt ccgcccggct tattatcctc cttattgaca      120

aacagagcgg tcgcggcggc gactctcggc gtgcggtgat agccaagcca tgggagacaa      180

gaagagcccc accaggccga agcggcagcc gaagccgtcc tcggatgagg gttactggga      240

ctgtagcgtc tgcaccttcc ggaacagcgc cgaggccttc aagtgcatga tgtgcgatgt      300

gcggaagggc acctccaccc gggacagcaa ggaagggggg aagctggtgt cctactccac      360

agccagtctt ggggttagag gaaccctgag aaatagagta ggtggtggca gctcagaaga      420

gaagaaacag gctgaatacc tggcacctgg aagaagaagg aatatagtac acaggggagt      480

tggcccagga cagagaagtg ggcctagttt aaaagaggct tgaggcccac atgggggccc      540

ctgacatttt ttttttttac cagtacatct aagctcttgt agatccaatt tttagtggtg      600

gaaacattac ttgaggagga ctcagagaag cattgtcatt tggattgaaa ctgaagaggc      660

tctgggcaac tcaccagaaa tctaagggac actgtgttcc tgaaagtaag tgttctacac      720

cacgaccctc tcagcttctt ccttcctctc tctgaattct cttctctttt gattttggct      780

ctaagttaaa cctaagagct ctaatttctc tgttatctgt tattttccta gtggtttctg      840

aaattcaggg tagaatctgt gtttgtatag aacagtgtgg aacagggtat tgttactaga      900

gaagatattg attgcatcac agaatattaa tatttttcct ctctggtaat gttaaaaaaa      960

caagattaaa ggactgcaga acggtgttga gaagcaaaag tttcagtagt tggaagaaat     1020

aattctccat aattgactta ttaatgaaca gggtaatttc cagagtaagg ttggcaagta     1080

ctaaagccaa gactggatag ctgcagagca gaaggatgca gtttgctaat gatttgtttg     1140

tgtgacgcac agatgggatt tgaatccttt gggtcagact gacctttgaa ctgattctgc     1200

ctcattgcca aatgttaggc caagtctaag ccattctaga catttgaaaa acttttttct     1260

ttttagacct gcagagaaga ttgagtcctt gttctacctt tgaagtcttc tttttttctt     1320

ttttcttttt tgagataaga tctcattctg ttgcccaggc tgggttgcag tggcatcatc     1380

caggctcact gcagcctcga actcccaggt tcaaggaatc ctcccacctc agcctcccaa     1440

gtagctgaaa ctacagatgc acaccaccat gtgtggctaa ttttcttatt ttttgtagag     1500

atgggggatc tctatgttgc ctaggctagt ctcaaactct tgagctcaag tgatcctcct     1560

accttggcct cccaaagaac tgggattata ggaatgagcc accattcggc ccctttaaag     1620

tctttattgg caatataatt ttttttcttt aaataatatt aagttcaaat tctttatgca     1680

acagaagccc atttcctttg gctatatcca tggtaggtca tgtctttcta gagaacgaag     1740

ttacattcat ggcatgtatt tcaaaataaa atgatttgtt gtagcttcag ttcctcaagt     1800

tttaatttta ttttagattt tggggtacat gtgcatgttt gttacttggg tatattgcag     1860

agtggtggga ttgggattcc agtgtaccca ttacccaaat ggtgaacgtt atacccaaca     1920

ggtcattttt cagcccctca ctccaaaatt ttttacattg tgcttttgtg agagaaacag     1980

tagtaaatgt caaactgaca ggaaattttt taaaaggaaa caaaatgcca cggtgacaca     2040

ttattttcaa gatgctgcac agtctttata tctgaagttt cttttctttc ttttcttttc     2100

ttttcttttc ttttcttttc ttttctcttt ttttttttga ggcagaattt gagacagtct     2160

tgctctgtcg cccaggctgg agtacagtgg cgtgacctcg gctcactgca acctccacct     2220

cccaggttca agcaattctc atgcctcagc ctctgtggta gctgggatta caggtgcccg     2280

ccaccacacc aggctaattt ttgtattttt agtagagatg gggtttcact atgctggcca     2340

ggctggtctc aaactcctga cctcaggtga tccgtctgcg tcggcttccc aaagtgctgg     2400

gattacagga gtgagacact gtgcccagcc tatctgaaga ttcttataag gcaagaaatg     2460

tcccaaatat aaatgcaaga aactttagga aattaaggat cattcttggc tggcccagtg     2520

gcccacacct gtaagcccag caccttggga ggctgagaca ggaggatttc ttgaggccag     2580

gagtttgaga ccaacctggg caacacagtg agatctcgtc tctactaaaa attaaaaaaa     2640

ttagctgggt gtggtggtgc atgcctgtgg tcccagctac tcaggaggct gaagtgggag     2700

gatcccttga gccccagagt tcgaggttgc agtgagctgt gatcatacca ctgcactcca     2760

gcctgggcaa cagagtgaga ccttgtctca aaaaaacaaa attctgagtc atcagagaaa     2820

atgaaatatt aaatattaag gatagtctgt atgagggtga taatcaatgt gtgatgatta     2880

atttaagact ggtgtcttat tggtacttca tctagtagtg gacagttact taatattgct     2940

taattcagat agcaaatatt tagaaatgaa aatgatagaa ttattggttt gggtttcaaa     3000

ctgtggtcta aatggttcat accaggcttt caaatgtaac aggtaatgtt acattttgtt     3060

agaggatatt ataacagtcc tttaggtttc tcataggtgt tattttagag agctataaaa     3120

aagatttcac atagtagaaa gagtgctaga tgttacacta gtatgatttt ggtaacctgg     3180

gttcatatct catttcatat caaccatttc aatattcagc attcagcaaa tgtttattga     3240

gcatcttatt taagggctga gttggatact agacatacag tggtgagcaa aatggatttt     3300

tttgtttctt taaaatttta cagttttgca aattagaacc gctttaactg taccaagctc     3360

tatatgtgag gtttagtgtt agtagatctt tcctttatgt gtaggctgaa gaggtggaac     3420

ttcttcatta aaaatatatg ttgtttataa ctgaacacag tattattatt atggttaggt     3480

aaaaagagtg agttatttca gcttctttta aaagtaagct ataaaatcca cattctgaaa     3540

gaagcttaaa ccaactatca tctggtagaa atcttttcag catcgttgtt ttcttgtcat     3600

acttgcttta tgtcttcaaa tttgaggttt ggcactgatt cttctagact tttggtgtag     3660

gaatgggaga aaaaaattga ggaccatcta cataagtcct ttttaaagaa atgcatggtt     3720

cctgagccgc ctcctgtcta tctgaggagc ctttctagca accatttagt tgttcagaga     3780

ctccttattc taggagattt cttacttgtt tgttttttgt cctgtaagag gactcacact     3840

ggttaattgt atatgggtaa attttacaag tgattattag tgtttgtgta gtctggatat     3900

cagagtggtt ttcaaagtgt agtctgaggg acactgagag tccctgagat ctttttagtt     3960

gaagctttct atgaggttca cactgttttt ataataattt gaagatgtta tttgcctttt     4020

tcactgtgat ggtgcagagg cagtgatggg taaaactgcc agcaccttag catgaatcaa     4080

agcagtggca ccaaattgct atcttcattg taatattcac caccatgtac atgcatgcag     4140

taagaataat gtcagtttga attaagaata tccttgaagc agaaaaattt actaatttta     4200

ttacatctca tatttttaaa aatattctgt ctgaccaaat gggaactaca cataaagcac     4260

ttctactgta taccaaagta cagtggttaa gggaaagcac atgtgtagtt tgtcttgcaa     4320

gcagagctag tctttttgtc atagagcatc atttttactt gaaagactac ctgaaatacc     4380

atagttattc agacttggat atttagcata tattttcttg aaaatgaata tattcaaaaa     4440

atatatcact tcaaggaaaa cacttgatac tatatgttgc cagtgataat cattcaagtg     4500

aaaattagaa tttttgaaaa tttgtagcaa caatgagctt tagagtttct gtgtataaag     4560

acttttctga gaagattagt ggtggtatca atgaatataa tttctgatat ttcaccatga     4620

aatgtgtcag catttggaag ctacgcataa ctcagcaaac aaatggttcc tagttaccga     4680

tgtatgattt tacaaaactg taatgggtaa tccatcaaag tacaaaatac caacagattt     4740

taagggaaca ctgaaaactt cattgatgtg gtttcagatt tcatattgca actaaccttt     4800

gagaaacaac tgtgttttta tgtagtatca aagaataaca cctatagtta tctgaaaatg     4860

ctattcaact acttacctct tttcaactgt atatctgtga gagtccagat tttcttaata     4920

tttttggacc aaaacaacat attgcaacaa attgaatgct gagatagatg tgacaatcca     4980

ggtgtcttct actaaccaga tgttagaggt ttgcaaaaat atacgatgcc actcttcata     5040

caaaatatct ttgttttgga aaataataag tttttaaaat aaaaatatgt cattt          5095


<210> 4586
<211> 4662
<212> DNA
<213> Homo sapiens

<400> 4586
caagcggcgg cagcggggtc ctgtactctt gctgtggctg ggcggctagt tcaagttgcc       60

atagctgcga gtctggggag agcacagtcg gttgagtcgc tgcgtttggt cagttgcacc      120

ttctgggtca ctggtagccg cgggagccgg gtggggccta ggcgatgatc cggcattaag      180

gagctgggat catcctccgt ctcaggtggt ttggggaaag tgtaggggca accaaagatc      240

atcggcttga ctaggccctt tgccctgaac ctcatgaaga aatgatagga ggcagacata      300

tgtgcctaaa aagagcgttg agctcagaga agagcaactc ggagttttgg gggtgtgctt      360

tgatttgtgt acatcaatgg cagaatcatc cagcgaatca gatcacttcc gctgtcgtga      420

ccgattgagt ccatgggctg ccagatcaac gcacagggga actcgaagtc ttcctacagt      480

agaagttacc gagaaggtca acactataac aagtacttta caggatacca gtcggaacct      540

gcgacaagtg gaccagatgc ttggacgata ccgagaatac agtaatggac aggcgggtgc      600

gatagaacat ttaaaagaaa gcttggaaca atcaatcgac caactccgga gtcaacgttt      660

attgagaaac tcaggaggga gaagtatttc tgttacaagt ttgagtgcaa gtgaccttga      720

tggtggcact gggtcagagc tccatcattt tccacctacc tcacctctca aggactatgg      780

ggatccacag ggtattaaac gaatgagatc aagaactggt gtccggtttg ttcaagagac      840

tgatgatatg actcagcttc atggttttca tcagtctctt cgagacctca gcagtgaaca      900

aattcgcctt ggagatgatt tcaacaggga gctttccaga aggagccggt cagatgccga      960

aacaaaaagg gctttggaag aattgactga aaaacttaat gaagcccaga aacaagaagt     1020

ggtttcagat cgggtggagc ggcggcttca ggaactggag agagagatgc gcacagaaag     1080

ggagctggtg gaaagacgcc aggatcaact gggactcatg tccctgcagc tacaggaggc     1140

actaaagaaa caagaagcta aagcagatga gcatgagggg gcaataaaaa ataagctaag     1200

acaaactgaa actgagaaga atcaacttga acaggaattg gagctatctc gaaggttatt     1260

gaatcaatca gaaggcagcc gagaaacact tttgcatcag gtagaagaac tgcgtacaca     1320

acttacgaaa gcagaaggtg atcgaaaggg tttacagcat caagtatctc agatttccaa     1380

gcaacagtca aactatcagg atgaacaagg ggaggactgg agatttagga gaggggttga     1440

gcgggaaaaa caggacctgg agaagcaaat gtcagatttg agagtgcagc tgaacttcag     1500

cgcaatggca tctgagttag aggaagtgaa acggtgcatg gagagaaaag acaaggagaa     1560

agcacatttg gcatcacaag tagagaattt aacacgtgaa ctggagaatg gggaaaaaca     1620

gcaactgcag atgttggatc gacttaagga gatccagaat cactttgaca catgtgaggc     1680

cgagcgtaag catgctgacc ttcagatctc agagctgact cgccatgcgg aggatgcaac     1740

caagcaggct gagcggtacc tcagtgagct ccagcagtca gaggctctga aagaggaggc     1800

ggagaagagg agggaagacc tgaaactgaa agctcaagaa tccattaggc agtggaagct     1860

taagcataag aagttagaac gagcgttgga gaaacaatct gaaactgttg atgaactgac     1920

aggcaagaat aatcagattt taaaagaaaa ggatgaattg aaaacccagc tgtatgcagc     1980

attacaacaa atagagaatc ttcgaaagga attgaatgat gtcctaacaa agcgtgccct     2040

tcaggaggag gagcttcact ccaaggagga gaaattacgt gatattaagt ctcatcaagc     2100

tgaccttgaa ttggaagtta agaattccct ggataccatc catagactgg agagcgaatt     2160

gaaaaagcag agtaagatcc aaagccagat gaaagttgag aaagctcact tggaggaaga     2220

aattgcagag ctcaagaaga gccaggccca ggacaaagct aaacttcttg agatgcaaga     2280

gtccatcaag gacctgagtg ccatccgagc agatcttgct aataaattgg ctgaggaaga     2340

gagagccaag aaagcagtgc ttaaggacct ttctgacctc actgcacagg caaaatccag     2400

ggatgaagaa acagctacaa tcatcacaca gttaaagctg gaacgagatg tgcaccagag     2460

ggagctgaaa gatctcacat catcattgca gagtgtgaaa acaaaacacg aacagaatat     2520

ccaggagctt atgaagcact ttaagaaaga aaagagtgag gctgagaatc atatcaggac     2580

tctgaaggct gaaagtttag aagagaagaa tatggctaaa attcatcgtg gtcagctgga     2640

gaagttgaaa tcacagtgtg acagactgac agaggaatta acccagaatg aaaatgagaa     2700

caaaaaactg aagctaaaat atcaatgttt gaaggatcaa ctagaagaaa gggaaaaaca     2760

tataagcatt gaagaggagc acttaaggag gatggaagag gccagattgc agctcaagga     2820

tcaacttctt tgcttggaga ctgaacagga atccattctt ggtgtgatag gaaaggaaat     2880

tgatgcagct tgtaaaacat tctccaagga ctcagtggag aaattaaaag ttttttcatc     2940

tggtcctgat atacattatg acccacatcg ctggttagca gaaagcaaga ctaaacttca     3000

gtggctctgt gaggaactga aagagagaga aaacagagag aaaaatctgc gacaccagct     3060

gatgctctgc agacaacaac tcaggaattt gactgaaaac aaggaatctg agttgcagtg     3120

tctctttcaa cagatagaaa ggcaggagca gcttctggat gaaatacatc gtgagaagag     3180

agatctactg gaagagaccc aaagaaaaga tgaagaaatg ggatctctgc aggaccgtgt     3240

aattgcatta gaaacgagta cccaagtggc cttggaccat ctggagtctg tgcctgagaa     3300

actgagccta ctagaagatt tcaaagactt cagagattcc tgcagttcat ctgagagaac     3360

tgatggaaga tattccaaat acagggttcg cagaaattct cttcagcatc accaagatga     3420

caccaagtac agaaccaaaa gtttcaaagg tgacagaacc tttctggaag gttcccacac     3480

tcgtgggtta gatcactcat cctcttggca ggatcacagt cgcttcctgt ctagtccaag     3540

attttcatac gtgaactcat ttaccaaaag aactgttgct ccagattcag cttcaaacaa     3600

ggaagatgcc acaatgaatg gaacaagttc acaacccaaa aaagaggaat atgggagcta     3660

aaaaagcaaa tgtaatttgt tattttacat gagtatgtta caaataataa catctctatt     3720

cttacagcaa tttggcccag attatctaac agacatacct gcagctttgg ctctttggta     3780

ttgccaaaca ttgacaaaag tgacaatact gttggtcctt gtgaatggta aaccaatcca     3840

aataatatca gatcatgaat gatgtgcagc taatttattt gcaacttata ctagcacaga     3900

aagaatgata ttttttcact ttgtattttc ctttttcaag tgtggtcagt cacattttcc     3960

caaccaaaat ttggatttct aattgaggcc ttttaaaaat tactggctaa aaagaaggaa     4020

aatgagtttc ccttgaggca aaagttgcca gcactttaga ttcagggagc atttatatac     4080

aactgatttt ttgaaaaatt ttctccctaa taaattatca tgtgttataa catgtggaga     4140

tgtgcatata taacattaga cagtccactt tataaatgct caggactttt atatctatca     4200

tcttaacagt ccacaactgc ataccgtagc tgaaaattat ttccaatcat ccatttttaa     4260

tagcaataaa gaattcataa atgatatctg aactgtagag cactgtaaag aattcatagc     4320

acaatttatt tatttgtctt tttgtggcca aatatcctac tgtgatcact tcagtcatat     4380

cctggaccgt ctttggttta ctgtgactaa aatcatagca ccaaactcct ttgtccatga     4440

gatttatata taatcttgta taatttggtc ctatctgctt ctaccatccc aacttttttc     4500

atcaaagtgt ctaagaacgt attcccttta cacgctgatc tcctagtgga gaaggattta     4560

tattaaatgc taagtaatag taaactttca ggaactgaat cctattgggt catggattct     4620

gcatagacaa gggcaataaa gcaatacctt tgtaatatgc at                        4662


<210> 4587
<211> 1711
<212> DNA
<213> Homo sapiens

<400> 4587
cgaccctcag cagccagccc ggcccgcccg cgcccgtccg cagccgcccg ccagacgcgc       60

ccagtatgag ggagatcgtg cacatccagg ccggccagtg cggcaaccag atcggggcca      120

agttctggga agtcatcagt gatgagcatg gcatcgaccc cagcggcaac tacgtgggcg      180

actcggactt gcagctggag cggatcagcg tctactacaa cgaggcctct tctcacaagt      240

acgtgcctcg agccattctg gtggacctgg aacccggaac catggacagt gtccgctcag      300

gggcctttgg acatctcttc aggcctgaca atttcatctt tggtcagagt ggggccggca      360

acaactgggc caagggtcac tacacggagg gggcggagct ggtggattcg gtcctggatg      420

tggtgcggaa ggagtgtgaa aactgcgact gcctgcaggg cttccagctg acccactcgc      480

tggggggcgg cacgggctcc ggcatgggca cgttgctcat cagcaaggtg cgtgaggagt      540

atcccgaccg catcatgaac accttcagcg tcgtgccctc acccaaggtg tcagacacgg      600

tggtggagcc ctacaacgcc acgctgtcca tccaccagct ggtggagaac acggatgaga      660

cctactgcat cgacaacgag gcgctctacg acatctgctt ccgcaccctc aagctggcca      720

cgcccaccta cggggacctc aaccacctgg tatcggccac catgagcgga gtcaccacct      780

ccttgcgctt cccgggccag ctcaacgctg acctgcgcaa gctggccgtc aacatggtgc      840

ccttcccgcg cctgcacttc ttcatgcccg gcttcgcccc cctcacagcc cggggcagcc      900

agcagtaccg ggccctgacc gtgcccgagc tcacccagca gatgttcgat gccaagaaca      960

tgatggccgc ctgcgacccg cgccacggcc gctacctgac ggtggccacc gtgttccggg     1020

gccgcatgtc catgaaggag gtggacgagc agatgctggc catccagagc aagaacagca     1080

gctacttcgt ggagtggatc cccaacaacg tgaaggtggc cgtgtgtgac atcccgcccc     1140

gcggcctcaa gatgtcctcc accttcatcg ggaacagcac ggccatccag gagctgttca     1200

agcgcatctc cgagcagttc acggccatgt tccggcgcaa ggccttcctg cactggtaca     1260

cgggcgaggg catggacgag atggagttca ccgaggccga gagcaacatg aacgacctgg     1320

tgtccgagta ccagcagtac caggacgcca cggccgagga agagggcgag atgtacgaag     1380

acgacgagga ggagtcggag gcccagggcc ccaagtgaag ctgctcgcag ctggagtgag     1440

aggcaggtgg cggccggggc cgaagccagc agtgtctaaa cccccggagc catcttgctg     1500

ccgacaccct gctttcccct cgccctaggg ctcccttgcc gccctcctgc agtatttatg     1560

gcctcgtcct ccccacctag gccacgtgtg agctgctcct gtctctgtct tattgcagct     1620

ccaggcctga cgttttacgg ttttgttttt tactggtttg tgtttatatt ttcggggata     1680

cttaataaat ctattgctgt cagataccct t                                    1711


<210> 4588
<211> 411
<212> DNA
<213> Homo sapiens

<400> 4588
aagcacatct acaatcaagg agaggggcag gctttacctt ttgaaggaag aagtatgaaa       60

gtgtatcact gactgatcaa gtagagctaa aaaacattcc cttcaattta aaaaatgttc      120

ccgactctta acaccccagt tgagaactac tgatcttaga tgtattaaag taaaatgaat      180

gaaagtaaac ctggtgactc acagaacctt gcttgtgttt tctgtcgaaa acatgatgac      240

tgtcctaata aatacggaga aaagaaaact aaggagaaat ggaatctcac tgtacattac      300

tactgtttgt tgatgtcaag tggaatttgg cagagaggca aagaagaaga aggagtttat      360

ggttttctaa tagaagatat caggaaggaa gtgaatagag cttctaaact g               411


<210> 4589
<211> 3236
<212> DNA
<213> Homo sapiens

<400> 4589
gcgtcccgcc tcctccgctc cctgcgctcc cgccacctcg gcaactccgc gcccgcctcc       60

cgcctccgtc ggaagcctcc gccgcagtaa ggctcccggt ctcgctgctg tctctttaaa      120

tggtggggct acgagccgcc cctgcagctg ctccctgggt ggccccgcgc gccgcttttg      180

aggggcgaac caagatggcg gcggttttgg ctgtgtgagg aagacggaag agacggcggc      240

ggagggaaac cgacttccac tagtccgggt cgcttgggcg gccgggggcc ctcagagtct      300

cccgggcagt ggtagcagtt gcagcaggat caggcgcctg tcggcttctg acgtttaaaa      360

cagggggagc ggaagggagc cactggccgc ggtggcaggg ccaggtataa ggaaggaaaa      420

tatggcggcg gcggcggcgg cctgaggagg cggcggcggc gcgggaagct gcttcgcgga      480

gatcatggcg gaggcgggag cagggcagtg acgggagccc cgagttccta gcgctgcggg      540

gcgggaggct acgaagcgct gcgcggcccc ctcggggctg ccgggcgccg ggctcgccag      600

gcctggacaa tagcgccggg gagccggagg cgaggaaagg cggcggccca gagctcggtc      660

cctggagcgg gccatgcagg cggcggcgcg gccccgcggc gcccagcggc ggcagtgagg      720

ccggggagcc ctccgctcgc gggcgccctc acgcctcgcc cctcgcctct ccagggcccc      780

tttcctgggc gtctactggc ggggcccccg ccccggttcc cgggcggcac gatgaccgac      840

acccggcggc gggtgaaggt gtacacgctc aacgaggacc ggcagtggga cgaccggggc      900

accgggcatg tgtcgtctgg ctacgtggag cggctgaagg gcatgtccct gcttgtcagg      960

gctgagagcg acggttctct acttttagag tcgaaaataa atcctaacac tgcataccag     1020

aaacaacagg aagatgaaaa atttctgaca gatttgtttg cacaactaac agatgaagca     1080

acagatgagg aaaaaagaca ggaattggtt aactttttaa aagaattttg tgcgttttcc     1140

caaacgctac agcctcaaaa cagagatgct tttttcaaga ctttgtcaaa catgggcata     1200

ttaccagctt tagaagtcat ccttggcatg gatgatacac aggtgcgaag tgctgctact     1260

gatatattct catacttggt tgaatataat ccatccatgg tacgagagtt tgtcatgcag     1320

gaggcacaac agaatgatga tgtaagtaag aagttaacag agcaaaaaat aaccagcaag     1380

gatattttgc tcatcaacct cattatagaa catatgattt gtgatacaga tcctgaactt     1440

ggaggagcag tccagcttat gggcctgctt cgaactttag ttgacccaga gaacatgcta     1500

gccactgcca ataaaacaga aaagactgaa tttctgggtt tcttctacaa gcactgtatg     1560

catgttctca ctgctccttt actagcaaat acaacagaag acaaacctag taaagatgat     1620

tttcagactg cccaactatt ggcacttgta ttggaattgt taacattttg tgtggagcac     1680

catacctacc acataaagaa ctacattatt aataaggata tcctccggag agtgctagtt     1740

cttatggcct cgaagcatgc tttcttggca ttatgtgccc ttcgttttaa aagaaagatt     1800

attggattaa aagatgagtt ttacaaccgc tacataatga aaagtttttt gtttgaacca     1860

gtagtgaaag catttctcaa caatggatcc cgctacaatc tgatgaactc tgccataata     1920

gagatgtttg aatttattag agtggaagat ataaaatcat taactgctca tgtaattgaa     1980

aattactgga aagcactgga agatgtagat tatgtacaga catttaaagg attaaaactg     2040

agatttgaac aacaaagaga aaggcaagat aatcccaaac ttgacagtat gcgttccatt     2100

ttgaggaatc acagatatcg aagagatgcc agaacactag aagatgaaga agagatgtgg     2160

tttaacacag atgaagatga catggaagat ggagaagctg tagtgtctcc atctgacaaa     2220

actaaaaatg atgatgatat tatggatcca ataagtaaat tcatggaaag gaagaaatta     2280

aaagaaagtg aggaaaagga agtgcttctg aaaacaaacc tttctggacg gcagagccca     2340

agtttcaagc tttccctgtc cagtggaacg aagactaacc tcaccagcca gtcatctaca     2400

acaaatctgc ctggttctcc gggatcacct ggatccccag gatctccagg ctctcctgga     2460

tccgtaccta aaaatacatc tcagacggca gctattacta caaagggagg cctcgtgggt     2520

ctggtagatt atcctgatga tgatgaagat gatgatgagg atgaagataa ggaagatacg     2580

ttaccattgt caaagaaagc aaaatttgat tcataataat ggcaacggcc taggatcagt     2640

acctgttgaa aaaaactggt tctccacccc tcccccatac aaaatccaca acaaagcgca     2700

gtggtctctt gtgaatgact gacacagatc agcctcttac acttgacttc tgctcatcaa     2760

gtgccaattc aatggagcag gaggagggga tatcatatat ttaggggaaa gacttaagcc     2820

tttgagctct ccagcttgga ccacacattg cccttttctc agggaaggaa atggaaacaa     2880

aaagccaaca gggcaggggt tttgtaagtg gaactctgga ttgactggtc agttgctaca     2940

atcagaatat gctttcttgg accatgtttg agactcagaa gaatgggcct ttctgccata     3000

attcttcact agtcaagaat gccagcagtt tctttgtata aagagacctg cctttaaaat     3060

catacattct gaacatttta gtcaagctac aacaggtttg gaaaacctct gtgggggagg     3120

ggcgagtata aagttttcct cttttttaac tgttcccttt gcccttcaaa ctgcagatat     3180

tttttttttt aagtggggac ttctccctac ttgattaaag attgagtgga attcta         3236


<210> 4590
<211> 869
<212> DNA
<213> Homo sapiens

<400> 4590
cagagaagga aggatcttct catgcacaga ggcaacaaat ggcaactttc tgagtcctca       60

tctataaaat gagcataata acatcaccta cttaattgga tttggtgagg attcactggg      120

tgagttcatg caaagcgctg agaacaggac cccccgcccc cgtggtttgg ggaaagtgta      180

ggggcaacca aagatcatcg gcttgactag gccctttgcc ctgaacctca tgaagaaatg      240

ataggaggca gacatatgtg cctaaaaaga gcgttgagct cagagaagag caactcggag      300

ttttgggggt gtgctttgat ttgtgtacat caatggcaga atcatccagc gaatcagatc      360

acttccgctg tcgtgaccga ttgagtccat gggctgccag atcaacgcac aggggaactc      420

gaagtcttcc tacagtagaa gttaccgaga aggtcaacac tataacaagt actttacagg      480

ataccagtcg gaacctgcga caagtggacc agatgcttgg acgataccga gaatacagta      540

atggacaggc gggtgcgata gaacatttaa aagaaagctt ggaacaatca atcgaccaac      600

tccggagtca acgtttattg agaaactcag gagggagaag tatttctgtt acaagtttga      660

gtgcaagtga ccttgatggt ggcactgggt cagagctcca tcattttcca cctacctcac      720

ctctcaagga ctatggggat ccacagggta ttaaacgaat gagatcaaga actggtgtcc      780

ggtttgttca agagactgat gatatgactc agcttcatgg ttttcatcag tctcttcgag      840

acctcagcag tgaacaaatt cgccttgga                                        869


<210> 4591
<211> 3851
<212> DNA
<213> Homo sapiens

<400> 4591
gcggtcagag ggccgaggcc tgggggcgag ctggggtcgt gcagtacagc ctctttccgg       60

caaatcacgc gagatttcgt tcacccgggc tccacaggga gtattttata cagaaatctt      120

gtgaaaccac tgcccaacca gagcaatgat tgttcaaaga gtggtattga attctcgacc      180

tggaaaaaat ggtaatccag tggcagagaa tttccgaatg gaagaagtct atttaccaga      240

taatattaat gaaggacaag tacaagttag aactctttat ctttctgtgg atccttacat      300

gcgttgtaga atgaatgaag acactggcac tgattatata acaccttggc agctatctca      360

agtcgttgat ggaggaggta ttggaattat agaagaaagc aaacacacaa atttgactaa      420

aggcgatttt gtgacttctt tctattggcc ctggcaaacc aaggttattc tggatggaaa      480

tagccttgaa aaggtagacc cacaacttgt ggatggacac ctttcatatt ttcttggagc      540

tataggtatg cctggtttga cttccttgat tgggatacag gaaaaaggtc atataactgc      600

tggatctaat aagacaatgg ttgtcagtgg ggccgcaggt gcctgtggat ctgtggctgg      660

gcagattggc catttcttag gttgttccag agtggtggga atttgtggaa cacatgagaa      720

atgcatcctc ttgacctcag aactgggctt tgatgctgca attaattata aaaaagacaa      780

tgtggcagaa cagctccgtg aatcatgccc agctggagtg gatgtttatt ttgacaatgt      840

tggtggtaac atcagtgata cagtgataag tcagatgaat gagaacagcc acatcatcct      900

gtgtggtcaa atttctcagt acaacaaaga tgtgccttat cctcccccgc tatcccctgc      960

tatagaggca atccagaaag aaagaaacat cacaagggaa agatttctgg tattaaatta     1020

taaagacaaa tttgagcctg gcattctaca gctgagtcag tggtttaaag aaggaaagct     1080

aaagattaaa gagacggtaa taaatgggtt ggaaaacatg ggagctgcat tccagtccat     1140

gatgacagga ggtaacattg gaaagcagat agtttgcatt tcagaagaaa tctctttgta     1200

attgctgtaa atgtcatcaa ggcaatcata gatttctttt ccattttgca tattttcaaa     1260

gatatgttaa aaaatcctta gactatacat agctcttgat ttaaatgtga tcataggtgt     1320

tatttttagt tgcatagggt atttgataca atcattaatg gatcatacac aataggtttt     1380

taaaaattaa taacttttag taattacttt tattaattta aaatagaacg cttgagaggc     1440

actttgtaaa gatttgttaa actggaaacg ttttacatga tctgatacaa ccattaatga     1500

atcatacaca ataggttttt taaaattaat attaataact tttattaatt taaaatagaa     1560

tgcttaaaat aaaatagaat gcttgagagg cactgagtaa agatttgttg aactggaaat     1620

gttttacatg attcttaaac tgaaacttgg tgtaaaaata gaattgagat ggcctttttt     1680

tcacattgta gactgaaaag agacttaatg gtatgatgtg tacataggga ctgggggcag     1740

gattgggggt ttcggagctt gtgtaacagt ttttgggata ggagaccagc ggttttgggt     1800

tgggattagt atgggaagat aaataactta ggttggttaa gttgacaaga tttactccag     1860

aggatcatct ctttgtattt gccaaataat ttactgtata gcctaaaaac tccatatata     1920

ttgagaaaag catatgttta ttttaggtta gcaggcacat actgtcaagt tgtaaagatt     1980

gagagggcaa acagatgtaa acatcacttg taggtgatta aaaagattga cagccgggcc     2040

tgatgtctca agcctgtaat cctagcactt tgggaggcag aggcgggcag atcacttgag     2100

gtcaggagtt caagaccagc ctggccaaca cggtgaaacc ccatctctct aaaaatacaa     2160

aaattagctg ggcgtggtgg cacacgcctg taatcccagc tactcaggag gctgaggctg     2220

gagaatcatt tgaacctggg agggggaggt tgccgtgagc tgagcttgca ccattgcact     2280

ccagcctggg cgacaagagt gaaattccat ctcaaaaaac aaaaacagat tgacaacaaa     2340

gacagtttca gaaaatgaca ggactgggca aattaacaaa tgtttgtaaa catgaatgtt     2400

caggaactac tgatgtacct caaaagtttg ttttattaat tgtactcaac cctcgcagaa     2460

cagtaaaact gaagattatt gtttctgaat gttttggctt atgattgtct acacactgcc     2520

aatatacttt tgtatgcaac atttgtaata agtagattca aactgtgttg gtaatcagcc     2580

tccccagttt tcgtgagtgg cccttttttg ttacttttcc tggaccattt catcgcctga     2640

gggggtttca cttttctctg tatgttgcta actcccaaat ctccatctgt atttctgacc     2700

tctttcttga gcactggacc tttacctcca agtaaatatc ctcaactctg gattgcatct     2760

tatactctgc ttttttcttt tcttttcttt tttgagatgg agtcttgctc agtcgcccgg     2820

cgtgcagcgg cacgatctcg gctcactgca acctccgcct cccgggttca agcgattctc     2880

ctgcctcagc ctcccgagta gctaggatta caggcgcgtg ccaccacgcc cggctaattt     2940

ttgtgttttt agtagagacg ggttttcacg gcgttaccca ggatggtctc gatctcctga     3000

cctcgtgatc cgcccacctt agcctcccaa agtgctggga ttaaaggcgt gagccacgga     3060

gtccggccta ctctgctttt ctaaagtgga attatcttcc tctgaaatgt ttctccttta     3120

ttttaaatca ccattagtaa tttgtgtacc caaacctgtc atcaaggctt atctttaacc     3180

ttgaaaatgc ctttttaaag agaactcctt taattcccac ggttgagtct ctcattcttc     3240

cgcacgcaaa tattttaaaa taagtaattt caagaagtca gtcaaactca caaagcttta     3300

acaaggtggc atccagcttg gaagtcaagt gttcaagccc gcagtcggga catccaagag     3360

ctctttacat cctaattaca acacggaacc cagactcact gcataccccg tcccgtatat     3420

aatgcaaaac ttgattctgc aagttccttt ctcgggcggt gaaacttcga aggtcctctc     3480

catggagacc tttgataaat gtttaagcag tgatcttttc tttcgcgttt gcctccattg     3540

caacgcctcc gctgatggga aaaactactc cctccgctac tgcggggtgg cagtgacgtc     3600

aacgaattag ctgacctgtt ttttcgggct tcgcggacat aggagtcccg aaggccgaga     3660

gtgagtgagt gagtgggagc ggggcggctg cggctcctcc tgtccggggc ggagccctgc     3720

gtcgcgggcc tggggaggcc ccgccagcac ccttgacgtc tgggtcccga gcagtgcggc     3780

agccacacga cactgaggcg agcgagtggg tgtgtgcgtg gggggtcagc caaacttcct     3840

gtcccgcgct c                                                          3851


<210> 4592
<211> 361
<212> DNA
<213> Homo sapiens

<400> 4592
tcacaactgt ttggtgacct acttcactga cctaatggaa acagactgta atcccatgga       60

gctaagcagt atgtcaggat ttgaagaagg ttcagagctg aacggttttg aaggaactga      120

catgaaagac atgaggctcg aagctgaagc agttgtaaat gatgttctct ttgctgttaa      180

caacatgttt gtctcgaaaa gcctgcggtg tgcggatgat gtggcctata tcaatgtgga      240

aacaaaggaa agaaacagat attgcctaga actcactgaa gcagggctca aggtggtagg      300

ctatgctttt gaccaggtag atgatcattt acagactccc taccatgaaa cagtctactc      360

c                                                                      361


<210> 4593
<211> 576
<212> DNA
<213> Homo sapiens

<400> 4593
ctttctacct ccttattcag agaaggaagg atcttctcat gcacagaggc aacaaatggc       60

aactttctga gtcctcatct ataaaatgag cataataaca tcacctactt aattggattt      120

ggtgaggatt cactgggtga gttcatgcaa agcgctgaga acaggacccc ccgcccccga      180

tttgtgtaca tcaatggcag aatcatccag cgaatcagat cacttccgct gtcgtgaccg      240

attgagtcca tgggctgcca gatcaacgca caggggaact cgaagtcttc ctacagtaga      300

agttaccgag aaggtcaaca ctataacaag tactttacag gataccagtc ggaacctgcg      360

acaagtggac cagatgcttg gacgataccg agaatacagt aatggacagg cgggtgcgat      420

agaacattta aaagaaagct tggaacaatc aatcgaccaa ctccggagtc aacgtttatt      480

gagaaactca ggagggagaa gtatttctgt tacaagtttg agtgcaagtg accttgatgg      540

tggcactggg tcagagctcc atcattttcc acctac                                576


<210> 4594
<211> 821
<212> DNA
<213> Homo sapiens

<400> 4594
attctcatcc ctgtgctcag agctctcaag cacccacgat ggccttctca ggccgagcgc       60

gcccctgcat tatcccagag aacgaagaaa tcccccgagc agcccttaac actgtccacg      120

aggccaatgg gaccgaggac gagagggctg tttccaaact gcagcgcagg cacagtgacg      180

tgaaagtcta caaggactct tctatgagtt tgaaggaaga aagtactgtg aacatgactt      240

tcagatgctc tttgcccctt gctgtcatca gtgtggtgaa ttcatcattg gccgagttat      300

caaagccatg aataacagct ggcatccgga gtgcttccgc tgtgacctct gccaggaagt      360

tctggcagat atcgggtttg tcaagaatgc tgggagacac ctgtgtcgcc cctgtcataa      420

tcgtgagaaa gccagaggcc ttgggaaata catctgccag aaatgccatg ctatcatcga      480

tgagcagcct ctgatattca agaacgaccc ctaccatcca gaccatttca actgcgccaa      540

ctgcggacag gaaggatctg actgccgatg cacaggagct gaaaggggag ctatactgcc      600

tgccatgcca tgataaaatg ggggtcccca tctgtggcgc ttgccgacgg cccatcgaag      660

ggcgtgtggt gaacgccatg ggcaagcagt ggcatgtgga gcattttgtt tgtgccaagt      720

gtgagaaacc ctttcttgga catcgccatt atgagaggaa aggcctggcg tattgtgaaa      780

ctcactataa ccagctattt ggtgatgttt gcttccactg c                          821


<210> 4595
<211> 3834
<212> DNA
<213> Homo sapiens

<400> 4595
ccgggcgcgc aggtgagcgg cagccggggt ggctgcgggc gaggggcggc ccccgagaag       60

ggctaggggc tcggggcgcc ggcgggccgt caggccttcc ggatggggac gcgacgccat      120

gcagctggct gggccgagag gggcggcagg ctgcaggggc cccgcgcccg tgttaagagg      180

ggtctggggg ccggtctggc cggcctggct ctcccggctc ccctcagacc tcggcgcccc      240

ggaaacgcac acttggggct ccgccgtctc cgctgggagg actggagccc ttctcgagca      300

tccccgcccg cacccgagca ttgaccggtg cccattgtca gcaagttctt cggcccccgc      360

ctcattcagg tattgtttct gaggcagctt cttcgttgcc gtttgcctgg cggtttgcag      420

agcgcttctc gcatacgctc gcttaatcct gggtgtgtca tagcaacgat caggaaactt      480

gggttttcga agcatctgtg ggcaaaactg cattccttga gaaatgctaa aggctcctga      540

ccccgccgga acctgggtga agaacttggg ctgttctggc agtctgcgca atcgtatttc      600

tgccttttgg gaggtaactc ctgcagaggc ggagccggct gttaagttaa gtcaacctcg      660

aaaggcctgg gtgcgggtgt tctatggccc agaagccaga tgtccttcgt tagaatcccg      720

gcactgacac ctattagccg cccagccact ttgagcggcc actgccctcc ccgagcccac      780

gttgcctcct ttgccgagtg tgagcggatt aaaatcttat gtgcatggat ttgttgggaa      840

gattaaatga tatgagtagg gcacgaacct gaacagagtc ctgaaacata cagctgttta      900

atcacagtga attaagacga ccagtttaag gagtgaaatg tttactgtct cggcaacttt      960

catgaatgcc ttggaaatac agcccaaaat attggtagat ggagaaacat ctggttcccc     1020

tttccacaac caccttttcg ttttagaacc agggtacttt gtatgcagtt gcttggattg     1080

ttgatttccc tcattctttg tagactcatc tcaagtattc tcagtaactt agattccctt     1140

gctcttcatt cagaaatatt tgttaaggtc cattaaatga aagtcaccac agttgatcat     1200

gtgaacagtg tcaagaatca ggccgaacct tcaaggagtt tatgttctaa aacggaagca     1260

tggtggtacc tgcttgtgga ggctgaggcg gaaggatcgc ttgagcccag gactttgagg     1320

ctgcataatt gcattgacgc tatccataga gtgcctgcaa tttcaaatat cagaaaggat     1380

cgtacgagct atgatcatgc cactgcactc cagcctgaac cacagagcaa gaccctttct     1440

ctcaataaag tggaagtttg ttcatttatt cagtaaatat ttattgattg ccttctgtgt     1500

gccaagcact gttctaggta ctgggattac agcagtgaac agataaatct cttccttcct     1560

ggaacttaca ttttattgaa gggaggagac atacaataaa tgagtgaata atatgctttg     1620

tggtgataag ggctgttgga aaaacgaaag caatgtaaag ggagtggaga tggggaagag     1680

agaagggact tgccattttt atatgagatg ctcggtgctg attatcacaa ctgtttggtg     1740

acctacttca ctgacctgtg aggattcctt cccttcaggt actggattct tgatctttct     1800

gcatcatcaa gaatggaaac agactgtaat cccatggagc taagcagtat gtcaggattt     1860

gaagaaggtt cagagctgaa cggttttgaa ggaactgaca tgaaagacat gaggctcgaa     1920

gctgaagcag ttgtaaatga tgttctcttt gctgttaaca acatgtttgt ctcgaaaagc     1980

ctgcggtgtg cggatgatgt ggcctatatc aatgtggaaa caaaggaaag aaacagatat     2040

tgcctagaac tcactgaagc agggctcaag gtggtaggct atgcttttga ccaggtagat     2100

gatcatttac agactcccta ccatgaaaca gtctactcct tgttggatac actcagcccc     2160

gcctaccgag aagcatttgg aaacgcactg cttcaaagac tggaagcttt gaaaagagat     2220

ggacagtcat gactacactt tttcctttca gaggggctgg tgctggtaca gaatgttgat     2280

ataaagctta aaattcttgc atatggtcat agaaaatgca tctttggttt tgtgttttta     2340

tcacttgctt ccaacttagg cttttggctc agaagattat tgaataatga tttgtcttag     2400

tttctgtttc agtaagggaa ttctgaggcc gttgctatga taccatcatt aagacattca     2460

catgtcttca tataatatct cttcatttca aatcctaatc actatttcat actattacag     2520

ggctttgatg ctgccagcac tgtcttttac ataggaaatt ctagatttgc acagtaatag     2580

aggaattaga agtacctaac tatacacttt gattcagcct gctaaatcag gggttcaata     2640

ctagcttgga caaactttgt agtaattaat tgctaccagc cttattggaa acaaattatc     2700

aactagtttc ccctgcacaa attttgaaat tcactgcttc acttaatcta tttatattac     2760

taataatgga ttaataaaga tgaattaatt atatattact taactagtat taaatgaaaa     2820

acagggactg aaatagttct gtattccgtg tttgcaacag ccagccaact aagcagagga     2880

taaaccgtta gcaaatgaat gtaataatta ctcatttcca agatatctaa gcacataagc     2940

aaatacagga acagacttca ttctttttct taacaaaaaa gcatcttcag tgtgtgattt     3000

aaaagaaaga agattctggt ttcctagaaa acaatatttt ggcctgtgtt gattcttatt     3060

ctgaatgtgt gtttacataa tgtacagtat atattcagaa agtatttttg cttcaacgtt     3120

tactttctat gatgtagtgc tttggtattc ctacagcacc ccaccttccc caacagatgt     3180

acagtgttct gtctccattc gaaatctaca atgtaatatg agtgcattgt atgggtttga     3240

aaccaaagga tgaatgaagc attcagagac ttaatatttg aaaaaggaat agtcagtatt     3300

ttatatttta ttacaggtac tgatatttat aaatttaata aactgtacca tgctgctgca     3360

tgttttcaag tacatgttga acagtaagga ttggggagtt gttttttaat ggtcacctaa     3420

agcagctgct atagaaatgt tgaactaaaa ttttgcatct ggtcatacct tcatgcattt     3480

atcatttgca gatatttttc catcattatt aaaaaacagg aacttttagg ctctgaagat     3540

catgtggacc agagcaaatt aaagttcagt ttgtgtcaca attcattgcc agacttcatt     3600

ggaatgcttt gtttgatgat gtatgttcat tctcagcttt attttcagat gcttaactgg     3660

gcaacgaagt ctaacttcag gttgaacttt ctcatgttta atctcaggct aaatgtaaat     3720

gatatttgta aagtttgaat aaaattctgt ttactcattt tgagttagta tgaaaaaaag     3780

tgattgtatg tttaagaatt gaaattgttc attttgtgat aaatgattaa ttcc           3834


<210> 4596
<211> 5064
<212> DNA
<213> Homo sapiens

<400> 4596
gtccctaacg gtcttcggaa gcgaagcagt gtcaacagtc cctggtaaac acaagtagta       60

ttacaagtcg ggagctcttc aagtcttgga tgagactgta gagcggtctt gtgcggcaat      120

gtgctacctt aaaataaata aataaataaa cccctgttat gtccggagtt tgtttccacc      180

cggagaggaa tggaagagca ccagagagcg cttagctttc tggttggatg ttttgggctc      240

tgaggtcagc ttggagaaga aaaaaaagat taagatgcca gtgaagagac ttcgtgaggt      300

agtttctcaa aatcatggag atcatttggt tttgctgaaa gatgagttgc cctgtgttcc      360

tccggcattg tctgcaaata aacgtcttcc tgttggaacg gggactagtt tgaatggaac      420

atcacgtggt tcatcagact taacttctgc tagaaattgt taccagcctc tattagaaaa      480

tcccatggtg tcagaaagtg atttttctaa agacgttgca gtgcaagtgt tgcctttgga      540

taaaatagaa gagaacaaca agcaaaaagc aaatgacatc ttcatttctc agtatacaat      600

gggacagaaa gatgctctaa gaacagtttt aaagcaaaaa gctcaaagca tgcctgtttt      660

taaggaagta aaggtacatc tgttagaaga tgcaggcata gagaaggatg ctgttactca      720

ggagactaga atttcaccca gtggaattga ttcagctaca accgtggctg cagcaactgc      780

tgctgccatt gcaaccgcag ctccgttgat aaaggtgcag agtgatttgg aagcaaaagt      840

caattctgtt acagaattac ttagtaaatt acaggagact gataaacacc tgcaacgtgt      900

tacagagcag caaacaagca ttcagaggaa acaagagaaa ttacattgtc atgatcacga      960

aaagcaaatg aatgtgttta tggagcagca cataaggcat cttgaaaagt tacaacaaca     1020

acaaatagat attcagactc attttattag tgctgcactc aagactagta gttttcagcc     1080

tgttagtatg ccctcctcca gagcagtgga aaagtattcc gtaaaaccag aacaccctaa     1140

tcttggtagc tgtaatccat ctttatataa cacatttgct tccaaacaag cacctttaaa     1200

agaagttgaa gatacgagtt ttgataaaca gaaatctcct ttggagacac cagcacctcg     1260

cagatttgct cctgtacctg tttcaaggga tgatgaacta tcaaagaggg aaaatctttt     1320

ggaagaaaaa gaaaatatgg aagtgtcgtg tcacagagga aatgtaagac tattggaaca     1380

aattttgaat aataatgatt ctttgacaag aaaaagtgaa tcatcaaaca ccacctcact     1440

aactaggtca aaaataggat ggactcctga gaaaacaaac agatttcctt cctgtgaaga     1500

gctagaaaca actaaagtga ctatgcagaa gtctgatgat gttcttcatg accttggcca     1560

aaaagagaaa gaaacaaata gcatggtcca gccaaaagaa tctctgagta tgttgaagct     1620

tccagatctt ccacagaatt ctgttaagct tcaaacaacc aatacaacaa gatctgtatt     1680

gaaagatgct gagaagattt tgagaggagt acaaaacaat aaaaaagtac ttgaagaaaa     1740

cctggaagct attattcgtg caaaagatgg agctgccatg tattcgctta tcaatgcttt     1800

atctaccaac agagagatgt cagagaaaat taggatcaga aagacagtgg atgaatggat     1860

taaaactatt tctgcagaaa ttcaggatga actgtcaaga acagattatg aacaaaaaag     1920

atttgatcag aagaatcaga gaaccaagaa aggtcagaat atgactaaag atattagaac     1980

caacacacaa gataaaactg tcaacaaatc tgtaattcca agaaaacatt ctcaaaagca     2040

aatagaagag cattttagaa atctacctat gaggggcatg cctgcttcaa gtttacagaa     2100

agagagaaag gaagggcttt tgaaagcaac cacagtaata caagatgaag attatatgtt     2160

acaagtctat ggaaagccag tttatcaggg ccatcgaagc actcttaaaa aaggaccata     2220

tctcagattt aattctccat ctcctaagtc cagaccacag agaccaaaag taatagaacg     2280

agttaaaggc actaaggtaa agtcaataag aacacagact gacttctatg caacaaaacc     2340

taagaagatg gattctaaaa tgaaacattc tgttcctgtg ttacctcatg gcgatcagca     2400

atatttgttc agcccaagta gagaaatgcc tactttttca ggtacattgg aaggtcatct     2460

gattcctatg gcaattcttt taggacaaac ccaaagtaat agtgatacca tgccacctgc     2520

tggagtgatt gtcagcaagc cacaccctgt aactgtgact acttctattc ctccatcatc     2580

tcgaaaagta gaaactggag taaagaaacc taacatagcc attgtagaaa tgaagtcaga     2640

aaaaaaggat cctcctcagc ttactgtgca ggtattaccc agtgtagata ttgacagcat     2700

ttcaaatagt agtgctgatg tcctttcacc tctgtctagc cccaaagaag catctcttcc     2760

tcctgtgcaa acttggataa agactccaga aattatgaag gtagatgaag aagaggtgaa     2820

gtttccagga actaactttg atgaaataat cgatgtcata caggaagaag aaaaatgtga     2880

tgaaattcca gactctgaac caattctgga gtttaacaga agtgttaaag ctgattctac     2940

aaaatataat ggtcctccat ttccgccagt tgcttctact tttcagccca ctgctgatat     3000

tctggataaa gtaattgaga gaaaagaaac actggaaaat agcttaattc aatgggtaga     3060

gcaagaaata atgtcaagaa ttatctctgg gctctttcca gtccagcaac agattgcacc     3120

tagtatcagt gtttcagtca gtgagacaag tgaaccactg acttctgaca ttgtggaagg     3180

aacaagcagt ggcgccctcc agctttttgt tgatgctggt gttcctgtga actcaaatgt     3240

gattaaacat tttgttaacg aagctcttgc tgagaccatt gctgtcatgc tgggtgacag     3300

agaagcaaag aagcaaggtc ctgttgctac aggtgtttct ggggatgctt caacaaatga     3360

aacatatttg ccggcaagag tgtgcacccc actgcctacc ccacagccta cgcctccttg     3420

ctcaccttca tcacctgcta aggagtgtgt tttggtaaag actccagatt cttctccctg     3480

tgattcggat catgatatgg cttttcctgt gaaagaaata tgtgctgaaa aaggagatga     3540

tatgcctgcc atcatgcttg ttaatactcc aacagttacc cctactacta cacctcctcc     3600

agcggcggca gtttttaccc caactttgtc agatatttcc attgataaat tgaaggtatc     3660

aagcccagag cttcccaagc catggggtga tggagacctg ccactggaag aagagaaccc     3720

taactcacct caagaagaac ttcatccaag agctattgta atgtctgtgg ctaaggatga     3780

agaaccagag agtatggatt tccctgctca gcctccacct ccagagccag ttccctttat     3840

gccatttcct gccggcacca aggccccttc cccctcacag atgccaggtt ctgattcatc     3900

aacactggag agcacattga gtgttactgt cactgaaact gaaactttag ataaacccat     3960

ctctgaagga gagattttat ttagctgtgg tcaaaaattg gcccccaaga ttttagaaga     4020

tataggactg tacctgacaa accttaatga tagcttatcc agcactctgc atgatgccgt     4080

tgaaatggag gatgatcctc ctagtgaagg gcaagtgatt aggatgtccc ataaaaaatt     4140

tcatgcagat gcaattcttt cttttgctaa acaaaaccag gagtcagcag tttcccagca     4200

agcagtctat cattcagagg acttggaaaa cagtgtgggt gaacttagtg aaggacaaag     4260

accccagcta acagcggcag cagagaacat cttaatggga cattctctct atatgcagcc     4320

acctgtcact aatacacagt ctttggatca acaatgtgat cctaaaccat tatctcggca     4380

atttgacaca gtttcaggta gtatttatga agattcatgt gctagtcatg gtccaatgag     4440

tttgggagaa ttggagttgg agccaaattc taagctggtt cttcccacaa cacttctgac     4500

agcacaagaa aatgatgtta atttaccagt agccgctgaa gatttttccc agtaccaact     4560

aaagcaaaat caggatgtta agcaagttga acacaaacca tcacaaagtt acctacgtgt     4620

tagaaataaa tctgatattg caccttcaca gcaacaagtt tcaccaggtg atatggatcg     4680

gacacaaatt gagcttaatc cgtacctcac atgtgtattt tcaggtggga aagcagtgcc     4740

actctccgct tcacagatgc cccctgccaa gatgtcagtg atgctgccgt cagtgaacct     4800

cgaggactgc tctcagtctc tgagtctcag cacaatgcag gaggacatgg agtcttcggg     4860

ggcagatacc ttctgaacgg gaagagacag ccagcacagt gtttatgcca ctggttttaa     4920

agtcatttta ccttggctta aaaccctctc tcagactgtt tggtttttga gcatattctg     4980

aaaaaaaaat tccaatattt taaaataaaa caaaaagcat aatttgggta tttaaagttt     5040

ttaaataaaa taagtataag tcat                                            5064


<210> 4597
<211> 4485
<212> DNA
<213> Homo sapiens

<400> 4597
agtgcgcact acgcccttgc tggcgccggg atcctccctc tctcgctcct ccctttctgg       60

gctgcaccgc tcacgccttc ctgttagtcc gagctgggag aagttcactc cgatcagctg      120

atcccaactg acaacaggag aggaggaagc ccgggaggca acgaaggagg agggtggcgg      180

agatggagat gaggatggat ctgccggtgt cctgaggaat agcctctgcc cccactggcg      240

ccctgcggcc ccccgacgcc gccttgctgc ggccgagctt ctcagtggta tcccctgaaa      300

tactgacttc aggtcgaatt atattgaaaa gctcctgacc actttctttc attaccaaaa      360

ctttgtagct gatgtccaac cgatgaaccc accaccgtga acccatcaga cctctctcag      420

atagccataa aagacccttc caagtcaatt ttgaccacat ctttgcttgc actttatgga      480

ggatgaaacc atcaaaccaa atcaacgttg ctgctaatac aagagtctta gaggcagcaa      540

attaaaaatt tgaacatttg tttgtgaaga actataacag gacatgaaag gtgttctttt      600

ttaaagtgtt cagaaccctg tggaagtttc gtgcagtctt cagactcaaa tcttcgtctt      660

cacccccggg gcaagctcag tgactattat atggtgggtg tgtttcctta ccagcgtgag      720

tatgagtgcc cagacttccc cagcagagaa gggcctgaat ccggggctga tgtgccagga      780

aagttacgct tgcagcggga ctgatgaagc tatctttgag tgtgatgagt gctgcagtct      840

gcagtgtctc cgctgcgagg aggagctcca tcggcaggag cgcctgagaa accatgagcg      900

gataagactc aaacctggcc atgtccctta ctgtgacctc tgcaagggtc tcagtgggca      960

tttaccaggt gttaggcaga gggcaatagt gaggtgccag acctgcaaaa ttaacttgtg     1020

cctggagtgc cagaagagga ctcattctgg gggtaacaaa aggagacacc ctgttactgt     1080

gtacaatgtc agtaatctcc aggagtcact ggaggcagaa gagatggatg aggagaccaa     1140

gaggaagaag atgactgaga aggttgtgag tttcctccta gtagacgaaa atgaagaaat     1200

tcaggtaaca aatgaagaag actttattag aaaattggac tgcaaacctg atcagcatct     1260

gaaagtggtt tccatttttg gaaatactgg tgatggaaag tctcatactc tcaaccacac     1320

tttcttttat ggtcgtgaag tctttaaaac ctccccgacc caggagtcct gcactgtggg     1380

agtgtgggca gcctatgacc cagttcacaa agtagcagtg atcgatacgg aagggctcct     1440

gggggccacc gtgaatctaa gccagagaac acggctgctg cttaaggtcc tggccatctc     1500

agacctcgtc atctatcgaa ctcatgcaga ccggctgcat aacgacctct tcaaattcct     1560

tggggatgcc tcagaagctt atctgaagca cttcaccaag gagctcaagg ccaccactgc     1620

tcgctgtggc ctggatgtcc ctttatccac actgggccct gcagttatca tcttccatga     1680

gaccgtgcac acccagctac tgggctctga tcatccctca gaggtgccag agaagctcat     1740

ccaggaccgg ttccggaagc tgggccgttt ccctgaagcc tttagttcca ttcactacaa     1800

gggaacgagg acttacaacc ctcccacgga cttttctggg cttcggcgtg ctttggagca     1860

gctactagag aataacacca cccgttctcc ccggcacccg ggagtcatct tcaaagccct     1920

gaaggcacta agtgaccgct tcagcggtga gatccccgat gaccagatgg cgcacagctc     1980

cttttttcca gatgagtatt tcacctgctc ctccttgtgc ctcagctgtg gggttggatg     2040

taagaaaagc atgaatcatg ggaaggaagg agtgcctcat gaagccaaga gccgctgcag     2100

atactcccac cagtatgaca accgagtgta tacctgcaag gcctgctatg agagaggcga     2160

ggaagtcagt gtagtgccca aaacatctgc ttccactgac tccccctgga tgggtctcgc     2220

aaaatatgcc tggtctgggt atgtgatcga atgtcctaac tgtggcgtgg tctatcgtag     2280

tcggcagtac tggtttggaa accaagatcc tgtggatacg gtggtgcgga cagagattgt     2340

gcatgtgtgg cctggaactg atgggtttct gaaggacaac aacaatgctg cccagcgcct     2400

gttggacggg atgaacttca tggctcagtc ggtgtccgag cttagccttg gacccaccaa     2460

ggctgtgact tcctggctga cagaccagat cgcccctgcc tactggaggc ccaactccca     2520

gattctgagc tgcaacaagt gtgcgacgtc ctttaaagat aacgacacta agcatcactg     2580

ccgagcctgt ggggagggct tctgtgacag ctgttcatca aagactcggc cagtgcctga     2640

gcggggctgg ggccctgcgc cagtgcgggt ctgtgacaac tgctacgaag ccaggaacgt     2700

ccagttagct gttaccgagg cacaagtgga cgatgaaggt ggaacgctca ttgctcggaa     2760

ggtgggcgag gccgtgcaga acactctggg agccgtggtg acagccattg acataccact     2820

aggtctggta aaggacgcgg ccaggcctgc gtactgggtg cctgaccacg aaatcctcca     2880

ctgccacaac tgccggaagg agttcagcat caagctctcc aagcaccact gccgggcctg     2940

cggacagggc ttctgtgatg agtgctccca tgaccgccgg gctgttcctt ctcgtggctg     3000

ggaccatccc gtccgagtct gcttcaactg caataaaaag cccggtgacc tttaacccca     3060

gccccctctc cgagtccttc acaattcctt aggttctcag ggttagaaac agtcttgcga     3120

ggtaggccct cctcccagtc acctgctgtg gtgtgtgtcc tctcctctcc gcatccaggg     3180

ccactttccc tcagtggggg tgagcctggc ggcaggcccg aaggtgtgga cccctcaggg     3240

caggggacct tgcaacttat cgcaaagggg aatgaacctg aatccgttgc atttatttca     3300

gttaaaaata atgaatatat atgtgtatat ctctctctca tatatacata tgaaaggcac     3360

tcggggcgta tcgaggctgc tgctggctgt gaagacttcg cacagtctcc tccgcacagg     3420

gtgaggtggc agtggcagca cgtcttcctc atgagccgag ccaggtccat ggccaccacg     3480

tggctggccc cttcctctgc tgctcttgga gccttggaag cctctcctgt ccttggctct     3540

tccctccatg cctgtcagct gcctggggag tgagcctccc tggtccttcc tgcctgaaac     3600

agcctgaagg gaattctccc taggtctcct gggagtcgag tcccaattct tggcttaagc     3660

ctgttttagt cagagaccac ccaacttagc gtgcaggtca ccggagtggg tggagggtca     3720

gaggtcgggt cttcggccct gagaagtaga aatgcagggg ccgtgctgtc cctggtcccc     3780

cagggaacag caaggaagga actgagcctt ctccagcagg gcttcctgtc ccgatgcttc     3840

tgtctccact cggctttccc aaaaggcggc acccagctcc tcaatcgaag catctgcctc     3900

ccacccctcg gccccctcaa gcccaccatc tgcttctgag tgtcgcacta ggattttcat     3960

tgcttatttt aaagtgtctt aatcctttgt tcccagacac acaacccctc tagctctcgg     4020

aggggcgatc atgagaaacc ttccagggaa actgagcaca ggatgaactg ttagttgttt     4080

ttaaaagtct atataaatat ttcaacagat cgtaaagaaa aaatttatct ctttggtcct     4140

tgcaagagaa gtcaaaggaa cttttgtttc tcctcaagag cctggacatc tctgtctgtc     4200

atgactggaa agggcccgtt gtgctgaaat cctatcatca tggtggattt gatcttcagt     4260

ggccaaacac gaattaaagt ataattctta actgaactgg tgggtgggtt gagctttagg     4320

gaagtatatg gcggtcattc ctggtgcgcc tatcggtgtg acatgagccc tggagtgtgt     4380

cgtccctctc agccctgctc ctcctgcctc ctggggtcca gtgactggga ccctactcta     4440

gaactgtgta ccatccaatt cgccatcata aaggaatctt cctgc                     4485


<210> 4598
<211> 1010
<212> DNA
<213> Homo sapiens

<400> 4598
ccaggagggg aaagggccag gaaagacagg ctccagtgcc gtaggatcca ggcatgcact       60

gtccgtgttt attgagcgcc tgctgtatgc tgggacctag catgagaagc gctgtcatgg      120

ggacccggaa aggcctctgc cgcagacatg gagaaactca gcgcgctgca ggagcagaag      180

ggcgagctgc gcaagcggct gtcctacacc acacacaagc tcgagaagct cgagaccgag      240

ttcgactcca cgcgccacta cctggagatc gagctgcggc gcgcgcagga ggaactggag      300

aaggtcacgg agaagctgcg caggattcag agcaactaca tggcactgca gaggatcaac      360

caggagctgg aggacaagct gtaccgcatg ggccagcact atgaggagga gaagcgtgcg      420

ctgagccacg agattgttgc cctcaacagc catctgctag aagccaaggt gaccatcgac      480

aagctgtcag aggacaacga gctctatagg aaggactgca atctagcggc ccagctgctg      540

cagtgcagcc agacctacgg cagggtccac aaggtgtctg agctgccctc ggatttccag      600

gagcgcgtga gcctgcacat ggagaagcac ggctgcagcc tgccatcccc gctctgccac      660

ccggcctacg ccgacagcgt ccccacctgc gtcattgcca aggtgctgga gaagccggac      720

cccgccagcc tgtcctcccg cctgtccgat gcctccgccc gcgacctggc cttctgcgac      780

ggggtggaga aaccaggccc gcggcccccc tacaagggag acatctactg cagtgacaca      840

gccctctact gcccggagga gcggcggcga gaccggcggc ctagcgtgga cgcgcccgtg      900

accgacgtgg gcttcctgcg ggcccagaac tccactgaca gcgcggccga ggaggaggag      960

gaggccgagg cggcggcctt cccggcgggc ttccagcatg aggccttccc                1010


<210> 4599
<211> 4079
<212> DNA
<213> Homo sapiens

<400> 4599
cacacaggcg atggccttgg agacacccac gccgggtcca cccagagagg gccaaagccc       60

tgcttctcag gctgggactc agcaccctcc tgcccaggcc actgcccatt cccagagctc      120

tccagagttc aagggctccc tggcctccct ctcagacagc ttgggggtgt ctgtcatggc      180

caccgaccag gactcctact ccaccagcag cacggaggag gagctggagc agttcagcag      240

ccccagcgtg aagaagaagc cctccatgat cctgggcaag gctcggcacc ggctgagctt      300

tgccagtttc agcagcatgt tccacgcttt cctctccaac aaccgcaagc tgtacaagaa      360

ggtggtggag ctggcgcagg acaagggctc gtactttggc agcctggtgc aggactacaa      420

ggtgtacagc ctggagatga tggcgcgcca gacctccagc acggagatgc tgcaggagat      480

tcgcaccatg atgacccagc tcaagagcta cctgctgcag agcaccgagc tcaaggccct      540

ggtggacccc gccctgcact ccgaggagga gctcgaagca attgtagagt ctgccttgta      600

caaatgtgtc ctgaagcccc tgaaggaagc catcaactca tgcctgcatc agatccacag      660

caaggatggt tcgctgcagc agctcaagga gaaccagtta gtgatcctgg ccaccaccac      720

cactgaccta ggtgtgacca ccagcgtgcc ggaggtgccc atgatggaga agatcctgca      780

gaagttcacc agcatgcaca aggcctactc acctgagaag aagatctcca tcctgctcaa      840

gacctgcaaa ctcatctacg actccatggc cctcggcaac ccagggaagc cctatggggc      900

ggatgacttc ctgcctgtgc tcatgtatgt gctggcccgc agcaacctca cggagatgct      960

tctcaatgtg gagtacatga tggagctcat ggaccccgcc ctgcagctgg gggagggttc     1020

ctactatctg accaccacct acggggccct ggagcacatc aagagctacg acaagatcac     1080

ggtgacccgg cagctgagtg tggaggtgca ggactccatc caccgctggg agcgccggcg     1140

tactctcaac aaggcccggg cctcccgctc ctccgtacag gtgaggcctg agagcgggag     1200

gggcccggtg gggccatgtc ccagacacca tccctgctgc ctgctggcta aggagccgtg     1260

acatcacctg gctgctccag ccgcccagcc ctgccttagg ggagcagtga gactccccac     1320

accagaggaa gggcccccag cccctgctgc cagtgtgtgt ccaggacttg ggtgcgtcta     1380

gaaacatatc agcaggcatt ggtgttctcc ctgggcaagc aggaagggtg caggaggaat     1440

gagacacacc catcattcct tagcccctcc taggacccag caccctgcag gggctggaga     1500

tggggacttg tcatcccagt ccctgcttta aggagcccac aggctcatct acagccttgc     1560

tccttagtcc ctggacaaat gcagcagctg ccaagggtct gcgtaacccc caccaaccca     1620

gtggcccacc cctccccata cctctctcta tacagactca gtattcaaac cagtcccgcc     1680

cctccccaac tccatcaccc cacccacccc caggctgcat caaatccagc tgcccccagt     1740

tccccaaaca tgcccagccc agttcactgg ctgctcaacc gctgccctca ctggtcaatc     1800

tccccttctt cactggctgt cactgcccat cctttaagac gactcagttt ctccaacagc     1860

ccctcctctg agaagccttc cctgatacac acacacaccg tttcacacag gctgggtggg     1920

gtgccctcct ctgggcttcc tgcggcctcc ccttttacag tgcatatcac atcctatcat     1980

cctctgcata tgaagctgtc acctctggga gggcacagcc catggttcac atgcctcagg     2040

ggcgccaagc ccagggcctg ggacagagca ggactgggtg tgtaaaaaag ggtgagagtt     2100

ggactagtga gccaggcaca tccagagctg tgagcagcta tgcagactca ctcctctgac     2160

acccagagca gaccagtcct gagccacact cctggctttc aagatggtgc atctataata     2220

agcagagccc aggcctggga gacaggaggc ttgagttctg gccccagccc tgtactagct     2280

tgctgtgtga ccctcagcaa tccctgcccc actctgggac tcagttttcc tgcccacaca     2340

ggctgactat ggctaatcaa tttaataact gactctctgg ggagaaaaca aaagctctga     2400

ttttagcttc tgtccatttc catggtgtga gtcctccatg gccaacttca acttggcatc     2460

actgaatgtg gagttggaaa gaagtgtatg cagtcggctc tccctggcgg gtgtgagcca     2520

gctccagcac acctctgttc ccatcccctc ccaacacccc ggactcccac agactgtagg     2580

gacatggaca ctcttggtcc aagcctggcc caggcatccc gtacttcctg cttctacctt     2640

aggggttcct gatgctgagc caggcagagt atggatgaaa cggaccaccc actgtttggg     2700

agacggaagc ttcggagggg ggtcccctca gcaccacatc tgggatctgg ggagggcacc     2760

accctctgcc ccctcccagt gcctcctccg cacaccatgc cttggggggt gggcaccctt     2820

ccctggggag gggaagccca gagctggaca gtcactagca ggtggatagt gccctgggag     2880

gcctaatgga ggacaaggag ccctgaggca gccactaaga cggagggagt gggccgggct     2940

tttcccctcc tggaagaaat gggcggtccc cgtgaagctc ttgacaggag cccggcctcg     3000

cctaagccct agccaccagt tgccatcacg gtctccgccg agccgggatc ctcagccgct     3060

tcccgcgcag gcctgctgtt cccaatccgg ccacaagggg gcagccccgc gcgcagcctc     3120

tctgcctgca gccctgagcc ccggggaagg cgaggccgct ccgggccgga gcttccagcg     3180

cctgctcgcc catttatggg aggcgggcgc tatccccact ttacagccgg ggctcgacga     3240

atcaaggcca cacaggcagt gggagcaaag gcaaagcccg gcaggtgtgg ggctgggtcc     3300

ctaggggtgg aggacggcgg gcgggcgccc tgctcgtgct gcgagtgccc agccccagcc     3360

cgcaggcgtc gcctcgcctt gcccgccctg ctcatgccgg gccttcccca cccgactgcg     3420

cccagcctcc ttcacccggt cccctcccgc tttaccaatc cctgccccac gcagctcctc     3480

agagccccag ggctcttgca gccctaaggg gctggactgt gttgcccgcc cgcactatgg     3540

gatgcccggg cgggctcgca cctcccttct tatctgtgct gccctccgtg cccagcattg     3600

cgcctggggt gcagggaact cacctggagg gagggaggga gggaatgaat gaatgaatga     3660

atgatgggga gcctgtggac cagcagccag gggacgcgcc ggctcctctt tgcagggact     3720

ccgagacgcg ccttaattca tctcccagaa ctgtcggccc agctgggaag ccaggcaggg     3780

agggggacgg gccccccgca ggctcgcggc agagacggga aaggcgcagg tgccggactc     3840

gcagacagct tggcgcccgc cacccgctat ccatccaggg aggggcctgg gccgggagag     3900

ggcgcctgag gagacagggc cccgccgtga ccacaggccc ctcgcgtctc cgcaggactt     3960

catctgcgtg tcgtacctgg agcccgagca gcaggcgcgg acgctggcgt cgcgggcgga     4020

cacccaggcc caggcgctgt gcgcgcagtg cgcggagaag ttcgcggtgg agcggccgc      4079


<210> 4600
<211> 2731
<212> DNA
<213> Homo sapiens

<400> 4600
gtgcgtccgc gccccagtgt cgggtctgcg tggatcggtc cttccaggac accgtcgcct       60

tcccggccgc gtcggagtcc ggcggcgacc tgcctctgaa acatggcagg ctcggatgct      120

gagtgggtaa ccattgccaa taaccttctt tttaagtgtc atatacatct gagaatacat      180

gaacttcaag actgtgatgc taatgttttt attgctcttt atcagtctat tttgggagaa      240

aaggtaccag acctcatagt tattcctagg agtcaagaag atgatgcaca caatgtacaa      300

gcagtaattg attcactggc cttggactac ttgcaggtca gcttgtctca cataacagga      360

gaaaatatag tgaaaggaga taaagaatct attaagaatc tcctggaaat atttgatggt      420

ttgttggagt atcttacaga acgcatcagt gaaacatctc atgagaaaag tgaaactgaa      480

cagtatttta aagaatctga tcgaggagaa cgtttggaag agccagaaag tactaaagaa      540

tctaaatcat catggaaaag agtttctttt gggaggtgct ccttgtcttc tgagatgttg      600

ggcccctctt gggatggaga tgaagcagaa tccactggtg aaatcattag acttggagac      660

acagcacaca ccttttctct aagaagtaat ggtgctcaat gtcctaatga aatgctgtct      720

aaaaaagcct tagcctcacc aagttctaaa tcacatgaag atatgttgta ccctcctagt      780

gttttgtcca agagtaggac atcctttgtt gaagacacgg aaaccctttc tgtgagtggg      840

attccaaatg ctaggaagct aggggagcct atccgagcag ctattccttt acatccaccc      900

taccaccctt cagagcctcg agcaccctgc cccataggaa aagaatactt gcattcaagt      960

cactgctccc cagccgtaaa ttctactgga gagcatacgg aattttctgg ggatctagat     1020

gatggacttt tcttaatttc caagttgcct aaaggcagca aatgggaagt atatccagct     1080

caggtccaag ggcctaggac aaggaagcct cccaaaggaa aaagaaatga aaacagagct     1140

acagcctcat cctgcaattc acctttcccc cagaggccaa gaaagagatt aacagaacaa     1200

gaattacatg atgtatcaga aaaactctct cagcggcttt ctgaactaga ttggatgtta     1260

aaaagtgctc tgggtgatcg gattaaagaa aagactgacc ataaagaaga aaatactgga     1320

aatgaggagg tagaggatgg aactgaggag acactgtctc agcacagtga tggcatcgtg     1380

gagtatgggc caaagaagtc aaggccagga ctttccatgc gtagaaagcc accctacaga     1440

tcccattcgc tctctccatc tccagttaac aaacacaaac agttccactt ggagagaaaa     1500

aggcagcgca agccaagaga aacagatgtc cgccaattcc aagcacaggc gtttactgaa     1560

gcatttgaaa gggaactaag aagacataaa gttcaagaga atattggacc tctaagaata     1620

catgagaagg aggaggaaac agaaaaaata tacagaggag aagctgttcg taaaggaact     1680

ccagaatgta gtcagccctg gaagatttac tctagaaaaa ccacaacgca gagtctaaga     1740

ggtggcctcc caaagccaaa taaagcagtt ccaatgaaag taagtgaaca cagtctcctg     1800

ccccttatgc tggagcagtt tccgtttctt tatgtttctg gcccaacact aagcaaaatg     1860

tggaaacagc aaattgcaca ggttgaacag cttaagaaag aagcatgtag agaaaatcga     1920

tcaaagaaga aactccaaga tgaaatagaa gaagccctaa gaaggcatga cctccttact     1980

acccttgtca agaaagaata tgaacataac aagagactgc aagacttcaa ggactgcatt     2040

cgtaggcaaa ggttgaccca atcaaagata aaagaaaatc gacagcaaat cgttcgtgct     2100

cgaaaatatt atgatgatta tagagttcag ttgtgtgcaa aaatgatgag aatgaggacc     2160

cgggaagaaa tgatatttaa gaaactgttt gaagaaggtt taaacattca aaagcaaaga     2220

ttacgagacc taagaaacta tgccaaagaa aagcgagatg aacaaaggag acgccaccag     2280

gatgaactgg actccatgga gaactactat aaggaccagt tttcattgct ggcagaagcc     2340

atatcacagg aacatcaaga acttaaagcc agagagaaat ctcaggccca gacattacat     2400

aaggtgaaga gggagctgag atctaagatg gagaaggaaa ttcagcagct gcaggacatg     2460

ataacacaga atgatgatga tgttttcttc cgggaactgg aagctgagcg cttcagatct     2520

cggcttcagc tggcttcctt tcagtacagt aaaagtccct ccctatgagg ccagacttga     2580

taatagtagg tgaaggttct ggaggccttt accaggacag agctagaatc gagccagtaa     2640

acagtctaag ccagaaaaat aattttcaaa tgctttacct gtattttcat tccagtactt     2700

tttatgattt tttaaataaa aattgttttc t                                    2731


<210> 4601
<211> 6683
<212> DNA
<213> Homo sapiens

<400> 4601
cccgcgcgcg aggccgccgg cggccgctct gccgtgggct cggcccgggc tgccacgagc       60

gtgcgggcct cgccgggcat gtcctaggcg gcggccccgc ccagcgctcg gccgggcggg      120

cgggcgggcg cgagggcagg gaccgagccg ggccgagctg gggaacaagc cggggaccaa      180

gccggggacc aagccgggga ctaaggcgag ccggagaccg agcccgaaca gcagtcccgc      240

agcgtggaca agcagcatgc cgtcatcaac tacgaccagg acagggacga gcactgggtg      300

aaggacctgg gcagcctcaa tgggacgttt gtgaatgaca tgcgcatccc ggaccagaag      360

tacgtcacgc tgaagctcaa cgatgtcatc cgcttcggct acgattccaa catgtatgtg      420

ctggagcgtg tgcagcaccg agtcccggag gaggcactca agcatgaaaa gtacaccagc      480

cagctgcagg tgagcgtgaa gggtttggcg cccaagagga gcgaggcact gccggaacac      540

acaccatact gcgaggcctc gaaccccagg ccggagaagg gggaccggag accaggaaca      600

gaggcagcct cttaccgcac acccctgtat gggcagccct cctggtgggg tgaggacgat      660

ggtagcacgc tgcctgacgc ccagcgccag ggagagccct acccagagcg ccccaaggga      720

ccagtgcagc aggacgggga gctccacggc ttccgcgccc ctgctgagcc tcagggctgc      780

tcgttccggc gggagcccag ctacttcgag atccccacga aggagacccc gcagccgtcg      840

cagccccccg aggtgccggc acacgagatg cccacgaagg atgcagaggc aggtgggggc      900

ggagcggccc ctgtggtgca gagccacgcc tccttcacca tcgagtttga tgactgcagc      960

cctggcaaga tgaagatcaa ggaccatatc accaagtttt ccctgcgcca gcggcggccc     1020

ccgggcaagg aggccacacc tggcgagatg gtgtcggctg agaccaaggt ggccgactgg     1080

ctggtgcaga atgacccgag cctgctgcac cgggttggcc ctggggatga ccgccacagc     1140

accaagagcg acctgcctgt ccacacccgc accctgaagg gccacaagca cgaggacggc     1200

acgcagagtg actcagagga ccccctggcc aaggcggcct cggccgctgg ggtgcccttg     1260

gaggccagcg gggagcaggt gcggctgcag aggcagatca agcgggaccc ccaggagcta     1320

ctacataacc agcaggcctt tgtcatcgag ttcttcgacg aggacacacc ccgaaagaag     1380

cgctcccagt ccttcacgca cagcccgtcc ggggacccca aggccgacaa gcgccgtggc     1440

ccaacgccgg ccgataggga ccgccccagt gtcccagccc cagtccaggc agggggccgc     1500

agctcggggc cacagagggc cggctcgctc aagcgggaga agacagagga acggctgggc     1560

agcccctcgc ccgcctcccg aacccctgcc cgccccttcg gaagcgtggg gcgccgctcc     1620

cgcctggccc aggacttcat ggcccagtgt ctgcgggaga gctccccggc cgcccggccc     1680

agccccgaga aggttcctcc ggtgctgccc gctcccctga caccccatgg gaccagcccc     1740

gtgggccccc cgaccccacc gcccgccccc acggaccccc agctgaccaa ggcacggaaa     1800

caggaggagg acgacagcct cagtgacgca gggacataca ccatcgagac cgaggcgcag     1860

gacacggagg tggaggaggc ccggaagatg atcgaccagg tctttggggt gttggagtcc     1920

cctgaactct ccagggcatc ttcggccacc tttcgcccag tcatcagagg ggacagagat     1980

gagtctgatg acgggggcgt ggcccagcgg atggcgctac tgcaggagtt tgcctcccgg     2040

ccactgggtg cggcccccca ggcggagcac cagggcctcc cggtgccggg ctcccctggg     2100

ggtcagaagt gggtgtcccg ctgggccagc ctggctgaca gctactcaga cccgggcctc     2160

acagaggatg gcctgggacg tagaggcggg gagccggagg ggtccctgcc tgtgcgcatg     2220

cggcgacggc tccctcagct gcccagtgag agggctgaca gccctgcggg cccagagagc     2280

agcaggagga gtgggcctgg gccaccggag ctggacagtg agcagcccag ccgcctcttc     2340

ggccaggagg agttggatcc tgacagcctc agcgatgcca gtgggtcgga cgggggccga     2400

ggccccgagc caggggtgga gccacaggac agcagacgca ggagccccca ggaggggccc     2460

acgtggagca ggggtcggcg ctcaccaagg gcccccgggg agccaactcc cgcctctttc     2520

ttcattgggg accagaatgg ggacgctgtg ttatctagga aaccgcttgc ggctccaggg     2580

gatggggagg gcctagggca gacagcccag cccagccccc cagcacggga tggcgtctat     2640

gtcagtgcca atgggagaat ggtcatccag ctacggcctg gacggtcccc agaacccgac     2700

ggccctgccc cagcctttct ccggcaagag agcttcacta aggagccagc cagtggtccc     2760

ccagcgcccg gcaagccccc ccacatctcc agccacccgc ttctacagga cctggccgct     2820

acccgggccg cacgcatgga cttccactcc caggacaccc acctgatctt gaaggagacg     2880

gagacggccc tggcggccct ggaggcccga ctcctctcta attctgtgga tgccgagtgt     2940

gaggggggca gcaccccgag gccgccggag gacgccctgt ctggggactc ggacgtggac     3000

acagccagca ccgtcagcct gcgtagtggc aagagcgggc ccagccccac aaccccccag     3060

cctctgcggg cacagaagga gatgtcgcca tccccgccag ctgcacagga cccgggaggc     3120

accgccctgg tcagtgcccg tgagcagtcc tcagagaggc agcatcaccc acttggcccg     3180

acggacatgg gccgtggaga gccggtacgg cgctcagcca taaggcgtgg ccacaggccc     3240

cgagggtccc tggattggcc cagtgaggag cgtggccctg tcctcgccca cctacccagc     3300

tcagatgtga tggcctccaa ccacgaaacc cctgaggcca ccggggcagg acggctaggt     3360

tctcgccgga aaccagcggc cccaccgcca tccccagctg cccgggagga gcagagccgt     3420

agctcagcca gctcccagaa ggggccgcag gccttgaccc gctccaacag cctgtccacc     3480

cctcgcccca cacgggcctc ccggctgagg cgggcccggc tgggggacgc ttcagacact     3540

gaggctgcgg atggtgagcg ggggtccctg ggcaaccctg agcccgtggg ccggccagct     3600

gctgagcagg ccaagaagct gtcacgcctg gacatcctgg ccatgccccg gaagcgggcc     3660

ggctccttca cagggactag tgaccccgag gcagcccctg cccgcaccag cttctctggc     3720

cgcagtgtgg agttgtgctg tgccagccgc aagcccacca tggccgaagc acgggctgtc     3780

tccaggaagg ctgccaacac agccaccacc acgggtcccc gccagccctt cagcagggcc     3840

cgctcaggca gtgcccgata cacctccaac acgaggcgcc ggcagcaggg ctcggattac     3900

acgtccacct ctgaggagga gtacggctcc cgccacggct cccccaaaca cacacgctcc     3960

cacacctcaa cagccactca gaccccgagg gctggcagct ccagccgggc tcgttcccgg     4020

gcccccggcc cccgggacac ggacgacgat gaggaggagc ctgaccctta tggtttcatc     4080

gtgcagacgg cagagattgc ggagattgcc aggctgagcc agacgctggt gaaggacgtg     4140

gccatcctag cccaggagat ccacgatgtg gctggggacg gtgacacact gggctcctcg     4200

gagcctgccc acagcgcctc cctcagcaac atgcccagca cccccgcctc gaccatctct     4260

gcccgggagg agctggtgca gcgcatcccc gaggccagcc tcaacttcca gaaggtgccg     4320

cccggctcgc tgaactctcg ggactttgac cagaacatga acgacagctg tgaggacgcc     4380

ctggccaaca agacgcggcc tcggaaccga gaggaggtga tcttcgataa cctgatgctg     4440

aacccggtgt cccagctgtc gcaggccatc cgtgagaaca cagagcacct tgccgagaag     4500

atgaagatcc tctttcagaa cacagggaga gcttgggagg acctggaagc caggatcaac     4560

gccgagaacg aggtgcccat cctgaagaca tctaacaagg aaatcagctc catcctgaag     4620

gaactgaggc gggtgcagaa acagctggaa gttatcaatg ccatcgtgga ccccagtggg     4680

agcctggacc tgctcacagg aaacaggagc ttggccagct ctgcacagcc ggggctgggg     4740

aagggccgcg tggctgccca gagcccaccc tcacccgcct cagccgaggc cctgctgcca     4800

gccctgcccc tgaggaattt cccacagcgg gccagctgtg ggcctcccag cctcccggac     4860

cccaccttcc tccctgatgc cgagaggttc ctgatctagg ccccagacct ggccaggcca     4920

gcctccctgt gcgtgtgcgt ctctgccttc cgtccgccgc acacccgcct gcctggccgc     4980

aggtggttct ccctgaagac ccccacatgt gccatatccc tgtgggcggg tgcctcccac     5040

gcccttgccc cctcgtcagc tcccagccag caccctactc accctgtcca gccccatggc     5100

cacccccacc cctgcctcgc cccctacagg cctctgggcc cagctcctgg ccaggctgct     5160

gccaaggtca agccctcaag ggcattaccc cgcctcctct tcatcactgt tatttttgtc     5220

tttagcttta aaggaaagag ttgttggtgc cattgcaggt gccccctcca ggcctgactg     5280

gctccgccag gcactaacct gccataaccc tttgtgctgg cctgcggcca ggcagaggaa     5340

gagaggtcga ctgtggggtc atttggtgcc aaacatggag gtgggcaggc tcacctgttc     5400

ctgggactgt ctgagatggc agggcacttg ccctggtggc tcccacctga ccccaggcct     5460

tttataggca ggagccccac tgcttccagc ctctggtgcc aacacagttg ccaaacccat     5520

tgagcttggg gctgccctgt ggaggcctcc tgggtatgga ccaggggctt gttgagagct     5580

gagccatgca cacaggtgca gacacccccc aactcccatg cacacggcta gtccaggcgc     5640

ctccacgctg caccgtgagg actgcagggc atgtccccgt gaggggctat gggcctctgt     5700

aggtgggctt ccaaggtcct gggtgcagcc gggtgcatgg cagcccttct ggcgggggtg     5760

agcgcacgac caaagtcact ggaagccggg tttccggaag ctcgcagctt ggcctgcacc     5820

acacgccctc cccttttggc ttcacgccat caggcctcaa gtgggcatgg gggcagggac     5880

gggcccagga actgttgttt tctcaggatt ctttcagctg ggaacatggc aggtgagcag     5940

agcttggtgc ctctgccgtg gcccctgctg gggcagcccg tgttgccgga gcctctaagc     6000

caaagagccc gttggccgtg gttggtgggg gtggacgtgg gggtgtccca cctggaccag     6060

actggcgtgg gtgagctcca caccctgcct ggcaatggta tgagagtcgg acctggacag     6120

ggccagctgc tgggggagcg gcactgggga ctggaggctg gaagcgggtg gtgtgtgtcc     6180

cctgtttact tttagctgag ctggggttgg gtgtacgggt tctgttcctc tgagcctgcg     6240

gcccacctga tgtttacgtg tgtgtgtgag ggggggcggg ggtggcaggt gtccccccct     6300

ggtccccgcc ccaagagcct gctgtctgta tggaggaggt gctagcccgg tccaccgggc     6360

tgctgcccac ccctgcatgc cccagttgcc caccccgcct gcccctggac atgaagtggt     6420

cacgcttcat ccacggctcc ttcccacccc tcggcagtgg ctgtgcaatg ttttaagttc     6480

acaagttcct gctcctcccc acactgagct cctttgttcc tccccctcca gcctttgcct     6540

gggaactggt ccttgtttgc cgggcttctc ggagggttca ctgtacattc gttctcaggt     6600

ggtcttgtgg ctgtctttcg gaaaatggtt attttatatg atttgtcatg gaatttgttc     6660

taataaatca ttcttctatc aca                                             6683


<210> 4602
<211> 756
<212> DNA
<213> Homo sapiens

<400> 4602
gccacagtcg gattcgctgc cgcagcagcc gccaccccca ggagccgccg ggaccctcgc       60

gtcgtcgccg ccgcggccca gatccccaca ccatgccgtc ggagaagacc ttcaagcagc      120

ggcgcacctt cgaacaaaga gtagaagatg tccgacttat tcgagagcag catccaacca      180

aaatcccggt gataatagaa cgatacaagg gtgagaagca gcttcctgtt ctggataaaa      240

caaagttcct tgtacctgac catgtcaaca tgagtgagct catcaagata attagaaggc      300

gcttacagct caatgctaat caggccttct tcctgttggt gaacggacac agcatggtca      360

gcgtctccac accaatctca gaggtgtatg agagtgagaa agatgaagat ggattcctgt      420

acatggtctg tgcctcccag gagacgttcg ggatgaaatt gtcagtgtaa aaccagaaaa      480

aatgcatctc ttctagaatt ttttaaaccc ttaccaagga aaaaaaaagg gatgttacca      540

actgagatcg atcagttcat ctaatcacag atcatcaaac agtagtgttc ccacctagga      600

gtgttaggaa gttgtgtttg tgtttcaagc agaaaaactg agctccaagt gagcacattc      660

agctttggaa actatattat ttaatgtagg ctagcttgtt ttcaaatttt aaaagtttaa      720

aaataaaata ctttgcattc taaaaaaaaa aaaaaa                                756


<210> 4603
<211> 6166
<212> DNA
<213> Homo sapiens

<400> 4603
gcggccgcgc ggcggggccc cgggaggcgg gtcgctgagc ggggcgcgcg gccccgagga       60

tgcgggagcg ggagcgggag cagcgctggc gtcaatgctc ccttcctcgg gccattggag      120

actccgttgc tttttaatgg cggcagcggc tgctgggtga gcagctggag gccggacagt      180

gttcgtccca tccggagagg atcgctttct cctggcgtca ccagcgctgg gttggtgggg      240

gtagcttttc cctctttgct cctccattct tgaagaaaga agaagatgcc actgccattt      300

gggttgaaac tgaaacgcac ccggcgctac acggtgtcca gcaagagttg cctggttgcc      360

cggatccaac tgcttaataa cgagtttgtg gagttcaccc tgtccgtgga gagcactggc      420

caggaaagcc tcgaggccgt ggcccagagg ctggagctgc gggaggtcac ttacttcagc      480

ctctggtact acaacaagca aaatcagcgc cggtgggtag atttggaaaa acctttgaag      540

aagcagctgg ataaatatgc attggaacct accgtctatt ttggagtggt gttttatgtg      600

ccttcagttt ctcagctgca gcaggagatt accaggtatc agtattatct gcaactgaag      660

aaagatatct tggaaggaag tattccttgt accttagaac aagcaattca gctagcaggc      720

ttagctgttc aagcggattt tggtgacttt gatcagtatg aatcccagga ctttcttcag      780

aaatttgcct tgtttcctgt gggatggtta caagatgaaa aagtattgga agaagcaacc      840

caaaaagtgg ccttactaca tcagaaatac agagggctca cagctcctga tgctgaaatg      900

ctgtacatgc aggaggtaga gagaatggat ggctatggag aagagagcta ccctgctaag      960

gatagccaag gaagtgacat atccattgga gcgtgtcttg aaggtatctt tgtgaaacac     1020

aagaatggaa ggcatcctgt ggtatttagg tggcatgaca ttgccaacat gtcccacaac     1080

aagtcctttt ttgcattaga gctggcaaat aaagaggaga ccattcaatt tcaaactgaa     1140

gacatggaaa cagcaaaata catttggaga ctctgtgttg cgcgacacaa gttttacaga     1200

ctaaaccagt gtaacctgca aactcagact gtcacagtga acccaatcag gaggaggtct     1260

tcttcaagga tgtctctgcc taaaccccag ccctacgtga tgcctccccc accgcagttg     1320

cactataatg gacattatac agaaccatat gcttcttccc aagataacct ctttgtgccc     1380

aaccagaacg gatactactg tcactctcag acaagcttgg atagagccca gattgacctc     1440

aacggtcgga tccgtaatgg cagtgtctac agtgcacaca gcaccaactc cttaaataat     1500

cctcagccct acttgcagcc ctcgccgatg tcgtccaacc ctagcatcac cgggagtgac     1560

gtcatgaggc ctgactacct cccgtcccat cggcacagcg ccgtgatacc cccgtcctac     1620

cgccccaccc cagactatga gactgtgatg aagcagctca acaggggcct ggtgcatgcg     1680

gaacggcaga gccactcgct gcgaaacctc aacatcggca gctcgtacgc ctacagcagg     1740

cccgcggcgc tggtctacag ccagcccgag atccgcgagc acgcacagct cccctcgcca     1800

gcggccgcac actgcccgtt cagcctgagc tacagcttcc acagcccgtc tccctacccc     1860

taccctgccg agcggcggcc cgtggtgggc gcggtcagcg tgccggagct gaccaatgcg     1920

cagctgcagg cgcaggacta cccgtctccc aacatcatgc ggacgcaggt gtaccggcca     1980

cccccaccct acccgccccc caggcccgcc aacagcacgc cagacctgtc ccgccacctt     2040

tacatcagca gcagcaaccc cgacctcatc acgcggcgcg tgcaccactc ggtgcaaacg     2100

ttccaggagg acagcctgcc cgtggcgcac tcgctgcagg aggtcagcga gcccctcacc     2160

gccgcgcgcc acgcgcagct gcacaaacgg aacagcatcg aggtggccgg gctcagccac     2220

ggcctggagg gcctgcggct caaggagcgc accctatccg cgtcggcggc agaggtggcg     2280

ccgcgagccg tctcggtggg ctcccagccc agcgttttca ccgagaggac acagcgagaa     2340

gggccggagg aggcggaggg cttgaggtac ggccataaga agtccctgtc ggacgccacc     2400

atgctaatcc acagcagcga ggaggaggag gacgaggact tcgaggagga gagcggggcc     2460

cgggcgcctc ctgcacgtgc gcgcgagcct cggcccggcc tggcccagga cccacctggc     2520

tgccctcgcg tcctgctcgc cgggcccctg cacatcctgg agcccaaggc ccacgtccca     2580

gacgcggaga agaggatgat ggacagcagc cccgtccgca cgaccgcaga ggcccagcgg     2640

ccctggagag acgggctgct gatgccctcc atgtcggagt ccgacctcac cacgtcaggc     2700

cgctaccgag cccggaggga ctctctgaag aaaaggccgg tgtcggacct tctctctggg     2760

aagaagaaca tcgtggaagg gctcccgcct ctagggggaa tgaaaaagac tcgagtagat     2820

gcaaaaaaaa ttggtcctct taaactggct gccctaaatg gactctccct atctcgagtg     2880

cctctgcctg atgaaggaaa ggaagtggct accagagcaa cgaatgatga aaggtgtaaa     2940

attctggaac aacgattaga acaaggaatg gtattcacag aatatgaaag aattcttaag     3000

aaacggctag ttgatgggga gtgctcaaca gcacgactcc ctgaaaatgc agaaagaaat     3060

cgattccaag atgttcttcc ttatgatgat gtgagagtgg agttggtccc aactaaagaa     3120

aacaacactg gttacatcaa cgcatcacat attaaggtct ctgtcagtgg aatcgaatgg     3180

gattatattg ccacacaggg accattacag aatacctgtc aagatttttg gcagatggta     3240

tgggaacagg gaattgcaat tatagcaatg gtgacagcag aagaggaggg tggaagggag     3300

aagagcttta ggtactggcc acgacttggt tccaggcaca acactgtcac ctatggaagg     3360

tttaagatca cgacccggtt ccgcacagac tctggctgct atgccaccac aggcctgaag     3420

atgaagcacc tccttactgg gcaagagagg accgtctggc acctccaata cacagactgg     3480

cctgaacatg gctgtccaga agacctcaag ggatttttat catatcttga agagatccag     3540

tctgttcgac gccatacaaa tagcacaagt gatccccaaa gccccaaccc tccgttgttg     3600

gtccactgca gtgctggggt aggaaggact ggcgtggtga ttttgtcgga gatcatgatc     3660

gcctgcctgg aacacaatga ggtgctggac atcccgagag tgctggacat gctgaggcaa     3720

cagagaatga tgctggtgca gactctctgc cagtacacat ttgtgtacag agtcctcatc     3780

cagttcctga aaagctccag gctcatctaa gctcccacaa tttcttacgg ggccagtcat     3840

gtgaagcgtt tacagcttaa aaaaaaagcg cttgcctaac tcatactttc ccgttgacac     3900

ttgatccacg cagcgtggca ctgggacgta agtggcgcag tctgaatggc ggcacgctga     3960

aggaaacgtg cgaagcacag gctgaagagg ggtttctaac ctgggaaagg tgctcaagga     4020

ggacttggtt tcaagggcct tgccctgccc cggtctgtcc ggtttgcagt acttgcacac     4080

attttggaga ttgtattttc tagacaattc tctattttac tgaagctatg ctgggcaatt     4140

ctggcaatca ttaaagtgca tagatttcta tcttaaacta atttttgata atggagtttt     4200

tattttatga caaatattta gggatttttc tagtgagaaa caactttgtg taaggatgat     4260

ccacagatat gagttgctcc tatataactt tgtatttaaa aatcatgtta ttatcttttg     4320

ttatttttta aaaaccttgg gtacttaata atggtttagt tgccaaactg aaaactatac     4380

tgagaatctg tgttattttg aaacatcaaa aggatttttc tatccagaac attttttatc     4440

ctaaaaattc tatatagttg taccttctgt ttttcaaatg agagctcaat tcatttagat     4500

actgaaatga gtcagttaat gtaaagttga ggatgaaggc acattattta aaatgtaaga     4560

gaataagcat tattttttca gtattattca tagatctaaa tgaatttgat tttattggtt     4620

gaaaatgaag tgaaaaacaa ttgcctaggg tggttttaag cacttttttg ttaaaaacaa     4680

atctgagttt taatatatgt gttgctttgt agatgacaca ataacaatgg gcgctgagaa     4740

gcgttttggg agagattaag gactaagagt atgtaagatg actaggacaa gagtaggtgg     4800

agtgtgatgg taaatgcagg atgccttcgt ctttacaaaa atgcagtatt atctatactc     4860

agactgaggt gctgggatgg cgagcagggg accccacagc actgtcccca gggaattcaa     4920

gtcctgtgac cgccagtgac ttactccgtt tccttggggc ttttcccacc tcaacctgta     4980

ttgtttcttt ttcataaata aattcagcat tatagtatca ttaaaagaag ccttaaagag     5040

gcgtattttt ccttttggtt gaaggaaggg aatagttaat aatagttttc acctcttctc     5100

ccaaaaagta cagtccaaat ttgtgcacag agattgctgt ggtattcaag aggtacttgc     5160

attttagctc cttaataatt ccctggccag tgttagctgt ttagtgcccc ctcacccatc     5220

ccatttaggc acatcccaat agacagagcc aggctgagtt acagggggag agtgtcatct     5280

ctggccccga ttaagatggc cttgtcacag tgaccgctga gtaggcatgg atgagtggga     5340

tatttagctg aggaaccctt tcccttttcc ttctttttgg ggtctcttct tacagtgaac     5400

ttccaaaatg tcaaatctag ggctgtttcc caaattacac tattctaggc atcattttga     5460

ttcccatgtc actccttaac tcacttcctt gagcactaca tgtatgttgt cagccacgag     5520

acaggacttc ctaaatagtg tgtgcaccag cctaactctg ccttacccag aaaccaacca     5580

cctaagagga aaactcagaa gatattaatg aaaactaatt gaaagtacgc acacttctca     5640

tgtaggaaca aaattaaaat tttacatttt tattttacaa aattaaaaaa ttacattttg     5700

taggaacaaa atgtaaattt tgtaaataca aaattctttt taaagtcctg tttaaagaac     5760

agtagaacta agtgaaaata ttcagaacga gctccttaga agaaaggaat aagaactttt     5820

tactggaact attttccatc tctagaaaaa gtgcttcttc ccctccccct ccctctccat     5880

ggtacgtttt tgtgaaaatg cttttctgtc aggtttaaac aaacagtttg acatagctcg     5940

ttgacaagaa catattgtaa aacaaatcta attaaagagt aatatgtggt ctatttgtgt     6000

tcctgttgta ataatttgat aagtaaactt ctgagggcaa aattactgtt taatattact     6060

cttaaaatgt tgcatgtttg gcgtcattcc taagagccat gtaattttaa acttttaatt     6120

gcagttagtg aatatgaaag gatttctgaa taaaaatcta tccaca                    6166


<210> 4604
<211> 3069
<212> DNA
<213> Homo sapiens

<400> 4604
gcgggcaggg gcggcgagtg cgcgggcgct cgccgccgcc cttctcggcg ggcagcgcgc       60

gaggaccagg ccgaggagga agtggcggcg gcggcggcgg gctccccgcc cgaggaggaa      120

gatgcagacc tttctgaaag ggaagagagt tggctactgg ctgagcgaga agaaaatcaa      180

gaagctgaat ttccaggcct tcgccgagct gtgcaggaag cgagggatgg aggttgtgca      240

gctgaacctt agccggccga tcgaggagca gggccccctg gacgtcatca tccacaagct      300

gactgacgtc atccttgaag ccgaccagaa tgatagccag tccctggagc tggtgcacag      360

gttccaggag tacatcgatg cccaccctga gaccatcgtc ctggacccgc tccctgccat      420

cagaaccctg cttgaccgct ccaagtccta tgagctcatc cggaagattg aggcctacat      480

ggaagacgac aggatctgct cgccaccctt catggagctc acgagcctgt gcggggatga      540

caccatgcgg ctgctggaga agaacggctt gactttccca ttcatttgca aaaccagagt      600

ggctcatggc accaactctc acgagatggc tatcgtgttc aaccaggagg gcctgaacgc      660

catccagcca ccctgcgtgg tccagaattt catcaaccac aacgccgtcc tgtacaaggt      720

gttcgtggtt ggcgagtcct acaccgtggt ccagaggccc tcactcaaga acttctccgc      780

aggcacatca gaccgtgagt ccatcttctt caacagccac aacgtgtcaa agccggagtc      840

gtcatcggtc ctgacggagc tggacaagat cgagggcgtg ttcgagcggc cgagcgacga      900

ggtcatccgg gagctctccc gggccctgcg gcaggcactg ggcgtgtcac tcttcggcat      960

cgacatcatc atcaacaacc agacagggca gcacgccgtc attgacatca atgccttccc     1020

aggctacgag ggcgtgagcg agttcttcac agacctcctg aaccacatcg ccactgtcct     1080

gcagggccag agcacagcca tggcagccac aggggacgtg gccctgctga ggcacagcaa     1140

gcttctggcc gagccggcgg gcggcctggt gggcgagcgg acatgcagcg ccagccccgg     1200

ctgctgcggc agcatgatgg gccaggacgc gccctggaag gctgaggccg acgcgggcgg     1260

caccgccaag ctgccgcacc agagactcgg ctgcaacgcc ggcgtgtcgc ccagcttcca     1320

gcagcattgt gtggcctccc tggccaccaa ggcctcctcc cagtagccac ggagccggga     1380

cccagagggg cagcgcaggg cgcagagcac acccgctggg ccagcagctc ccaacggcga     1440

tgctactact aagaatcccc agtgatctga ttcttctgtt ttttaatttt taacctgatt     1500

ctctgatgtc atgatctaaa tgaggggtag tgggggatgg aagagagtac caggtggtcc     1560

accgttgggg agtggggccg tccgcctgct ctctactgtg cagacctcct aactgagttt     1620

acacacgctt gtgtttgcaa cactaggtct ggatgggagg tgaggggtgt gcgtatggct     1680

gccatgccag tgtctgtgca catccctgtc tgttggtctc catggccact gtggaccggg     1740

acccttgggg gaagcctgcc catgtcgggc tgtgggaggc tgatcggtgc atgtgagagt     1800

ggcttccctt ctgcctgact ccccactccc tgacctgccc cttccttgtt tttcctccta     1860

ctggtctcca ccaaggcttt gttagccccc accctgcctg gtgtgcagct aacccctccc     1920

tccccacagc cagaggaggc cacagacccc tcaggggagt tccgcgctgg ggtctgggct     1980

gtgctccctc actaaaggga aggaaaggaa gctgggcgtc ctctgggccc cccaacacac     2040

gtcccattta gccctgcaca gcggtctcct tcccctaagc cagcactgct gctccctgga     2100

gcccgggaag gaggctgcct ggctggaggc ccgagccgat ggcgcctgtg ctgaggattt     2160

gtgctgtgat ttgggcaaat cattccaggt ctttgggcct ccaccccctt gtctctagtg     2220

gacatttgag atcagagagc accacagggc tggctttgtg ccctaacccc tgggatgcag     2280

cctgcctttc cataaagtca cctaggtgag gataggcgcg ggagcctcgg catgacacca     2340

tggagatcgg ggccctcttc ccagtgggtt cactcctttt cacacctgct gggtccctcc     2400

tcacccagca ggcctggtcc acctctcatt gcaagcccca agcactgagc cagcaggtgc     2460

cagggagcca cccgcccccc atcgcttctg cacacctcag actcacccca tcaccttggc     2520

agcaaagcac tggctctgcc gtctgacccc tgatccaggc agccccctct gcagagaaaa     2580

gggttgggga gaagcctctg cagtcctgga agatgtgggg tgctgggtga gaggcatcag     2640

cccccacaag tatgtttttg tgtcttaaga tagcagttta ctttgaaaaa gtgaaaaagg     2700

cttccgggct gtcctctgcc cagtgagatg gaggacgcta gagaaagtgc tgagtgtccc     2760

gagagaggcc cccgagccag tgcatggagg tccttcggcc tggctcagct gggctgcagg     2820

atgcccactt tgaggaggga ggcacagggc ttgggcgagg ggcagaggcc atcagaactg     2880

cccggctttt ttggaaactg aggacccaac aactaaccac gtttacacga cttgagtttt     2940

gaaccccgat taatgtctgt acgtcacctt tcctagttct gaccctgagc cctggggaac     3000

aggaaagcgt ggctggcctc ttgcactgct ttgtctccaa aataaactac tgaaatcaaa     3060

ccgcatttc                                                             3069


<210> 4605
<211> 2635
<212> DNA
<213> Homo sapiens

<400> 4605
agcaagatgg ccgccgctga ggaaggctgt agtgtcgggg ccgaagcgga cagggaattg       60

gaggagcttc tggaaagatg ccctcttcgc ttcccaagag aagtttttcc aggaactatt      120

cgacagtgaa ctggcttccc aagccactgc ggagttcgag aaggcaatga aggagttggc      180

tgaggaagaa ccccacctgg tggagcagtt ccaaaagctc tcagaggctg cagggagagt      240

ggaactccag catgtcggaa gaagagctga ccaaggccat ggaggggcta ggcatggacg      300

aaggggatgg ggaagggaac atcctcccca tcatgcagag tattatgcag aacctactct      360

ccaaggatgt gctgtaccca tcactgaagg agatcacaga aaagtatcca gaatggttgc      420

agagtcatcg ggaatctcta cctccagagc agtttgaaaa atatcaggag cagcacagcg      480

tcatgtgcaa aatatgtgag cagtttgagg cagagacccc cacagacagt gaaaccactc      540

aaaaggctcg ttttgagatg gtgctggatc ttatgcagca gctacaagat ttaggccatc      600

ctccaaaaga gctggctgga gagatgctga cgtggctttt tttctgtggc tcccagtggg      660

tctacggacc ttggctgaca tatgttggct ggctacagca aacatcattc aagatgtcca      720

gcaaagggag cagcacagat ggcagaacag acttagctaa tggaagcctg tctagcagtc      780

cagaggagat gtctggagct gaagagggga gggagacatc ctcaggcatt gaagtggagg      840

cctcagacct gagtttgagc ttgactgggg atgatggtgg ccccaaccgc accagcacag      900

aaagtcgagg cacagacaca gagagctcag gtgaagataa ggactctgac agcatggagg      960

acactggtca ttactccatt aatgatgaaa atcgagtcca tgaccgctca gaggaagagg     1020

aagaggagga agaagaggag gaagaagagc agcctcggcg ccgtgtacag cgcaagcggg     1080

ctaaccgtga ccaggactca tcagatgatg agcgggccct agaggactgg gtgtcctcag     1140

aaacatcagc tctaccccga cctcgctggc aagccctccc tgcccttcgg gagcgggagc     1200

tgggttcaag tgcccgcttt gtctatgagg cctgtggggc aagagtcttt gtgcagcgtt     1260

tccgcctgca gcatgggctt gagggccata ctggttgtgt caataccctg cactttaacc     1320

agcgcggcac ctggctggcc agtggcagcg atgacctgaa ggtggtggtg tgggattggg     1380

tacggcggca gccagtactg gactttgaga gtggccacaa aagtaatgtg ttccaggcca     1440

agtttcttcc taacagtggt gattctactc tggccatgtg tgcccgtgac gggcaggttc     1500

gagtagcaga actgtctgcc acacagtgtt gcaagaatac aaaacgtgtg gcccagcaca     1560

agggagcgtc ccacaagttg gcactggaac cagactctcc ctgtacgttc ttatctgcag     1620

gtgaagatgc agttgttttc accattgacc tgagacaaga ccgcccagcg tcgaaactgg     1680

tggtgacaaa agagaaagag aagaaagtgg ggctgtatac gatctatgtg aatcctgcca     1740

atacccacca gtttgcagtg ggtggacgag atcagtttgt aaggatttat gaccagagga     1800

aaattgatga gaatgagaac aatggagtac tcaagaagtt ctgtcctcat cacctggtga     1860

acagtgagtc caaagcaaac atcacctgtc ttgtgtacag ccacgacggc acagagctcc     1920

tggccagtta caatgatgaa gacatttacc tcttcaactc ctctcacagt gatggggccc     1980

agtatgttaa gagatacaag ggccacagaa ataatgccac agtaaaaggc gtcaatttct     2040

atggccccaa gagtgagttt gtggtgagcg gtagtgactg tgggcacatc ttcctctggg     2100

agaaatcatc ctgccagatt attcagttca tggaggggga caagggaggc gtggtaaact     2160

gtcttgagcc ccaccctcac ctgcctgtgc tggcaaccag tggcctagac catgatgtga     2220

agatctgggc acccacagct gaagcttcca ctgagctgac agggttaaaa gatgtgatta     2280

agaagaacaa gcgggagcgg gatgaagata gcttgcacca aactgacctg tttgatagtc     2340

acatgctgtg gttccttatg catcacctga gacagagacg ccatcaccgg cgctggcgag     2400

aacctggggt tggggccaca gacgcggact ctgatgagtc tcccagctcc tcagacacat     2460

cggacgagga ggagggccct gaccgggtgc agtgcatgcc atcttgaggc ctcataccta     2520

ggtggggcag gctggggctg ccaacctgat cctgcctggg caaccctttc ctgtcccagg     2580

ccctacattc agcagaaacg cactttggac tttttgcttt agataaaaga aagac          2635


<210> 4606
<211> 2529
<212> DNA
<213> Homo sapiens

<400> 4606
atgacgtcag atcgcccccg cccgccgcgc agcttccccg agcgagacca aaacaggtgg       60

aatccgggct ggagccggag ctccggcggc gcgggtggcg gcacgtccct ccaggtgggt      120

ggctctctgg gtctggcgac tcagcgctcc tcagccttgc cccctggtgc ccgctcgcga      180

ctgtcatcgc cccatcactt ctcgttgcag acagtaccac aggcacctgg agtaccggca      240

tcggtcgctg tggcccccga gtgtccgtca gagcctaggg gagcctgccc tcccgcgcct      300

cgtcggggcc cggccaggca ccttggccgc cggcgcacgg acgcgggcac gagcactaga      360

tcacggctgc tggacctcgg cacgttgaca agatttctct ggggtaccgc ggaggattac      420

tttgaatttc ggtggtcgcc tgtggtctgg catatttaga acttaagtct attatttcgg      480

gcaccatgac tttgaggctt ttagaagact ggtgcagggg gatggacatg aaccctcgga      540

aagcgctatt gattgccggc atctcccaga gctgcagtgt ggcagaaatc gaggaggctc      600

tgcaggctgg tttagctccc ttgggggagt acagactgct tggaaggatg ttcaggaggg      660

atgagaacag gaaagtagcc ttagtagggc ttactgcgga gactagtcac gccctggtcc      720

ctaaggagat accgggaaaa gggggtatct ggagagtgat ctttaagccc cctgacccag      780

ataatacatt tttaagcaga ttaaatgaat ttttagcggg agagggcatg acagtgggtg      840

agttgagcag agctcttgga catgaaaatg gctccttaga cccagagcag ggcatgatcc      900

cggaaatgtg ggcccctatg ttggcacagg cattagaggc tcttcagcct gccctgcaat      960

gcttgaagta taaaaagctg agagtgttct cgggcaggga gtctccagaa ccaggagaag     1020

aagaatttgg acgctggatg tttcatacta ctcagatgat aaaggcgtgg caggtgccag     1080

atgtagagaa gagaaggcga ttgctagaga gccttcgagg cccagcactt gatgttattc     1140

gtgtcctcaa gataaacaat cctttaatta ctgtcgatga atgtctgcag gctcttgagg     1200

aggtatttgg ggttacagat aatcctaggg agttgcaggt caaatatcta accacttacc     1260

agaaggatga ggaaaagttg tcggcttatg tactaaggct ggagcctttg ttacagaagc     1320

tggtacagag aggagcaatt gagagagatg ctgtgaatca ggcccgccta gaccaagtca     1380

ttgctggggc agtccacaaa acaattcgca gagagcttaa tctgccagag gatggcccag     1440

cccctggttt cttgcagtta ttggtactaa taaaggatta tgaggcagct gaggaggagg     1500

aggcccttct ccaggcaata ttggaaggta atttcacctg agtctcaggg aaccacgaag     1560

ggatatggca atgagtagag catgaaggta gaacagtcta tatactcttg tgacacatac     1620

aatccctacc ttgtgctgcc aagtaactca tttttgtgca attctcagta taagcccttt     1680

gtcgtttctg tgcctattta aagtctccta aaggtgtaat tgactaggaa ggatgtagtt     1740

ctacactgcc atttacctat ttaaattcat ccttgtgaat atctttgttg ttgttgttga     1800

gacagagtct cgctctgtca cccaggctgg agtgcagtgg cgtgatcttg gctcactgca     1860

tcctccgcct tccaggttta agctattctc ctgcctcagt tgcccgagta gctgggacta     1920

caggcatgtg ccaccacgcc cagctaagtt ttgcattatc agtagagacg gggtttcacc     1980

atgttggcca ggctagtttc gaactcctga cctcaagtga tccacctgct tcggcctctg     2040

aaagtgctgg gattacaggc gtgagacact gcgcccagcc tcatccctgt gaatttctta     2100

ttgtacacaa gttctttcac tatctgtgtg cagtgctctg aggggacaga caaggcttgg     2160

gtgtatatgc caaccagatc tcattgaagt atcagcttgt ttggtactag gtgcaagtgt     2220

agcatgtcac atgtgaccat gttggatcat tgacaatttt taggtatgta ctgacctaca     2280

tttatgatga agatcctgag cggaggttaa gatattaagt tattttccat atgaatcaga     2340

attatattga ttctgtgcaa tcaaaacaaa aggcagaata gaatgctgag attggttaag     2400

tttgcaatga ccatcttgaa ccacagattt ctgctatgtg tcatcaaaac atctagttct     2460

gagtaacatt ttcacgattg ttataaaatt ataggtgtga acttctaaaa taaaggaatg     2520

ctaataaaa                                                             2529


<210> 4607
<211> 2776
<212> DNA
<213> Homo sapiens

<400> 4607
ggcagcacca tgaactaagc aggacacctg gaggggaaga actgtgggga cctggaggcc       60

tccaacgact ccttcctgct tcctggacag gactatggct gtgcagggat cccagagaag      120

acttctgggc tccctcaact ccacccccac agccatcccc cagctggggc tggctgccaa      180

ccagacagga gcccggtgcc tggaggtgtc catctctgac gggctcttcc tcagcctggg      240

gctggtgagc ttggtggaga acgcgctggt ggtggccacc atcgccaaga accggaacct      300

gcactcaccc atgtactgct tcatctgctg cctggccttg tcggacctgc tggtgagcgg      360

gagcaacgtg ctggagacgg ccgtcatcct cctgctggag gccggtgcac tggtggcccg      420

ggctgcggtg ctgcagcagc tggacaatgt cattgacgtg atcacctgca gctccatgct      480

gtccagcctc tgcttcctgg gcgccatcgc cgtggaccgc tacatctcca tcttctacgc      540

actgcgctac cacagcatcg tgaccctgcc gcgggcgcgg cgagccgttg cggccatctg      600

ggtggccagt gtcgtcttca gcacgctctt catcgcctac tacgaccacg tggccgtcct      660

gctgtgcctc gtggtcttct tcctggctat gctggtgctc atggccgtgc tgtacgtcca      720

catgctggcc cgggcctgcc agcacgccca gggcatcgcc cggctccaca agaggcagcg      780

cccggtccac cagggctttg gccttaaagg cgctgtcacc ctcaccatcc tgctgggcat      840

tttcttcctc tgctggggcc ccttcttcct gcatctcaca ctcatcgtcc tctgccccga      900

gcaccccacg tgcggctgca tcttcaagaa cttcaacctc tttctcgccc tcatcatctg      960

caatgccatc atcgaccccc tcatctacgc cttccacagc caggagctcc gcaggacgct     1020

caaggaggtg ctgacatgct cctgctctca ggaccgtgcc ctcgtcagct gggatgtgaa     1080

gtctctgggt ggaagtgtgt gccaagagct actcccacag cagccccagg agaaggggct     1140

ttgtgaccag aaagcttcat ccacagcctt gcagcggctc ctgcaaaagg agttctggga     1200

agtcatcagt gatgagcatg gcatcgaccc cagcggcaac tacgtgggcg actcggactt     1260

gcagctggag cggatcagcg tctactacaa cgaggcctct tctcacaagt acgtgcctcg     1320

agccattctg gtggacctgg aacccggaac catggacagt gtccgctcag gggcctttgg     1380

acatctcttc aggcctgaca atttcatctt tggtcagagt ggggccggca acaactgggc     1440

caagggtcac tacacggagg gggcggagct ggtggattcg gtcctggatg tggtgcggaa     1500

ggagtgtgaa aactgcgact gcctgcaggg cttccagctg acccactcgc tggggggcgg     1560

cacgggctcc ggcatgggca cgttgctcat cagcaaggtg cgtgaggagt atcccgaccg     1620

catcatgaac accttcagcg tcgtgccctc acccaaggtg tcagacacgg tggtggagcc     1680

ctacaacgcc acgctgtcca tccaccagct ggtggagaac acggatgaga cctactgcat     1740

cgacaacgag gcgctctacg acatctgctt ccgcaccctc aagctggcca cgcccaccta     1800

cggggacctc aaccacctgg tatcggccac catgagcgga gtcaccacct ccttgcgctt     1860

cccgggccag ctcaacgctg acctgcgcaa gctggccgtc aacatggtgc ccttcccgcg     1920

cctgcacttc ttcatgcccg gcttcgcccc cctcacagcc cggggcagcc agcagtaccg     1980

ggccctgacc gtgcccgagc tcacccagca gatgttcgat gccaagaaca tgatggccgc     2040

ctgcgacccg cgccacggcc gctacctgac ggtggccacc gtgttccggg gccgcatgtc     2100

catgaaggag gtggacgagc agatgctggc catccagagc aagaacagca gctacttcgt     2160

ggagtggatc cccaacaacg tgaaggtggc cgtgtgtgac atcccgcccc gcggcctcaa     2220

gatgtcctcc accttcatcg ggaacagcac ggccatccag gagctgttca agcgcatctc     2280

cgagcagttc acggccatgt tccggcgcaa ggccttcctg cactggtaca cgggcgaggg     2340

catggacgag atggagttca ccgaggccga gagcaacatg aacgacctgg tgtccgagta     2400

ccagcagtac caggacgcca cggccgagga agagggcgag atgtacgaag acgacgagga     2460

ggagtcggag gcccagggcc ccaagtgaag ctgctcgcag ctggagtgag aggcaggtgg     2520

cggccggggc cgaagccagc agtgtctaaa cccccggagc catcttgctg ccgacaccct     2580

gctttcccct cgccctaggg ctcccttgcc gccctcctgc agtatttatg gcctcgtcct     2640

ccccacctag gccacgtgtg agctgctcct gtctctgtct tattgcagct ccaggcctga     2700

cgttttacgg ttttgttttt tactggtttg tgtttatatt ttcggggata cttaataaat     2760

ctattgctgt cagata                                                     2776


<210> 4608
<211> 545
<212> DNA
<213> Homo sapiens

<400> 4608
atcctttcta cctccttatt cagagaagga aggatcttct catgcacaga ggcaacaaat       60

ggcaactttc tgagtcctca tctataaaat gagcataata acatcaccta cttaattgga      120

tttggtgagg attcactggg tgagttcatg caaagcgctg agaacaggac cccccgcccc      180

cagtgaggag atgacaccta gactgaagta gcagcagtaa tgagctgaca gcctcacatc      240

tacttttggt gtgccgtgaa taagccatat gatcttaggt ggtttgggga aagtgtaggg      300

gcaaccaaag atcatcggct tgactaggcc ctttgccctg aacctcatga agaaatgata      360

ggaggcagac atatgtgcct aaaaagagcg ttgagctcag agaagagcaa ctcggagttt      420

tgggggtgtg ctttgatttg tgtacatcaa tggcagaatc atccagcgaa tcagatcact      480

tccgctgtcg tgaccgattg agtccatggg ctgccagatc aacgcacagg ggaactcgaa      540

gtctt                                                                  545


<210> 4609
<211> 534
<212> DNA
<213> Homo sapiens

<400> 4609
acacaccgcc cagcgctcgc acgacgggcc cctttcctgg gcgtctactg gcggggcccc       60

cgccccggtt cccgggcggc acgatgaccg acacccggcg gcgggtgaag gtgtacacgc      120

tcaacgagga ccggcagtgg gacgaccggg gcaccgggca tgtgtcgtct ggctacgtgg      180

agcggctgaa gggcatgtcc ctgcttgtca gggctgagag cgacggttct ctacttttag      240

agtcgaaaat aaatcctaac actgcatacc agaaacaaca ggacactctg attgtgtggt      300

ctgaagcaga aaattatgac ttggccctta gctttcaaga aaaagctgga tgtgatgaaa      360

tttgggagaa aatatgtcag gttcaaggaa aggacccttc cgtggacatc actcaggacc      420

ttgtggatga atctgaagag gagcgttttg atgatatgtc atcgccaggc ttagaattgc      480

catcttgtga attaagtcgc cttgaagaaa ttgcagaact tgtggcatca tctt            534


<210> 4610
<211> 896
<212> DNA
<213> Homo sapiens

<400> 4610
cggcgaggaa aaaaggcagt tttgaagcat ttagtggcaa aaggggtagg agacggctgc       60

tgaagtgtct actacattca ggggacctgg aaggcttcca gatatccgca atgaacaatg      120

aaaagaaatt gtgaaagaag gcgcttccct caagccggaa ctaatgaact cctgggtcac      180

gtggtgcgca cgcgccaaag gcacacgata aaggaaaacg cgggcttatc gtggccttta      240

aaatccggct tgccaagact tccgccctcg atcaagatgg tggttggacg gccttcctaa      300

cctttacggg gcctggcggt gctgacgcct gagctggtag gggtggagca ggtaggaaac      360

agcaaatgca gaagctgctg cgcggaagtc ggccatggac tggaaagaag ttcttcgtcg      420

gcgcctagcg acgcccaaca cctgtccaaa caaaaaaaaa agtgaacaag aattaaaaga      480

tgaagaaatg gatttattta caaaatatta ctccgaatgg aaaggaggta gaaaaaacac      540

aaatgaattc tataagacca ttccccggtt ttattatagg ctgcctgctg aagatgaagt      600

cttactacag aaattaagag aggaatcaag agctgtcttt ctacaaagaa aaagcagaga      660

actgttagat aatgaagaat tacagaactt atggtttttg ctggacaaac accagacacc      720

acctatgatt ggagaggaag cgatgatcaa ttacgaaaac tttttgaagg ttggtgaaaa      780

ggctggagca aagtgcaagc aatttttcac agcaaaagtc tttgctaaac tccttcatac      840

agattcatat ggaagaattt ccatcatgca gttctttaat tatgtcatga gaaaag          896


<210> 4611
<211> 770
<212> DNA
<213> Homo sapiens

<400> 4611
ctacgcctag gagggcccct gggtgttcac ccaccccccc ggggggcccc atcctgggcc       60

agggtccgct tcctcgaggg aaggggcgaa ttcctggaag gtctccttcc gggcgcagtt      120

gcaatggatt gccttggggg tgctgaaccc tgctgggggt acagagacgt ttccgaaact      180

cagcggctcg gtcgccccca aaggccaggc ggaacacacg cccacaccgc ggctcccttc      240

ccgaagctcc ccgcccgagg aggaagatgc agacctttct gaaagggaag agagttggct      300

actggctgag cgagaagaaa atcaagaagc tgaatttcca ggccttcgcc gagctgtgca      360

ggaagcgagg gatggaggtt gtgcagctga accttagccg gccgatcgag gagcagggcc      420

ccctggacgt catcatccac aagctgactg acgtcatcct tgaagccgac cagaatgata      480

gccagtccct ggagctggtg cacaggttcc aggagtacat cgatgcccac cctgagacca      540

tcgtcctgga cccgctccct gccatcagaa ccctgcttga ccgctccaag tcctatgagc      600

tcatccggaa gattgaggcc tacatggaag acgacaggat ctgctcgcca cccttcatgg      660

agctcacgag cctgtgcggg gatgacacca tgcggctgct ggagaagaac ggcttgactt      720

tcccattcat ttgcaaaacc agagtggctc atggcaccaa ctctcacgag                 770


<210> 4612
<211> 999
<212> DNA
<213> Homo sapiens

<400> 4612
tttcccgtcc ctgcgcggga agtggctgga cagcaccgcc accacccgcg ctgtcgtggg       60

cctcctcgcc ggctccgtgt aggtcatcct gtgttccaga ggcatcgttg ttcgagcaga      120

ggaatctcgt gaaggaaagt gggccgagtg gattgtacag cctctacaat atgccgaaaa      180

atgccgggtc taagttgtag attttatcaa cacaaatttc ctgaggtgga agatgtagtg      240

atggtgaatg tcagatccat tgctgaaatg ggggcttatg tcagcttgct ggaatacaac      300

aacattgaag gcatgattct tcttagtgaa ttatccagaa ggcgtatccg ttctatcaac      360

aaactcatcc gaattggcag gaatgagtgt gtggttgtca ttagggtgga caaagaaaaa      420

ggatatattg atttgtcaaa aagaagagtt tctccagagg aagcaatcaa atgtgaagac      480

aaattcacaa aatccaaaac tgtttatagc attcttcgtc atgttgctga ggtgttagaa      540

tacaccaagg atgagcagct ggaaagccta ttccagagga ctgcctgggt ctttgatgac      600

aagtacaaga gacctggata tggtgcctat gatgcattta agcatgcagt ctcagaccca      660

tctattttgg atagtttaga tttgaatgaa gatgaacggg aagtactcat taataatatt      720

aataggcgct tgaccccaca ggctgtcaaa attcgagcag atattgaagt ggcttgttat      780

ggttatgaag gcattgatgc tgtaaaagaa gccctaagag caggtttgaa ttgttctaca      840

gaaaacatgc ccattaagat taatctaata gctcctcctc ggtatgtaat gactacgaca      900

accctggaga gaacagaagg cctttctgtc ctcagtcaag ctatggctgt tatcaaagag      960

aagattgagg aaaagagggg tgtgttcaat gttcaaatg                             999


<210> 4613
<211> 3338
<212> DNA
<213> Homo sapiens

<400> 4613
aagaacaaat tcacgttttg tgaaggtggt cctgatgtcg gctaccatca gctgtaaaga       60

gtttgcagac tactttgctg ttcctgttca aaacaagatg aatcctgcat atatttttga      120

agtggaaggc aagccccatt cagttgaaga gtattatctt aatgatttgg agcacattca      180

tcatagcaag ctctctcctc atctcctgga ggaaccggtg ataactaagg atatatatga      240

agttgctgtc tctctcattc agatgtttga tgacttggat atgaaggaga gtgggaacaa      300

ggcttggtcg ggggcccagt ttgtgttgga gcgaagcagt gtgttggtgt ttttgccagg      360

tctgggtgaa ataaattata tgcatgaact tctcacaagc ctggttcata aaaggttgca      420

ggtctatcca ctccattcaa gtgtggcttt agaagaacag aataatgtct ttttaagtcc      480

agtccctggg tacagaaaga ttattctgtc caccaatatt gcagagagtt ctgtcacagt      540

tccagatgtc aaatatgtta tagatttttg tttgactaga actttggtct gtgatgaaga      600

tacaaattat cagagtctgc gattgagttg ggcttctaaa accagctgta atcagagaaa      660

aggccgtgct ggacgagtgt ctagagggta ctgttaccgg ctggtacaca aggatttctg      720

ggacaactcc atccctgatc atgttgttcc tgagatgttg cgttgtccat taggaagcac      780

gatcttgaaa gtgaaattac ttgacatggg tgagccgaga gctctgctgg ccactgccct      840

ttccccgcct ggtctgagtg acattgagcg caccatcctt ctactaaagg aggttggagc      900

acttgcagtg agtgggcaga gagaagatga aaacccccat gatggtgaat tgaccttctt      960

aggaagagtt ttagcccaac ttcctgtaaa tcagcaactt ggtaaactca tagtccttgg     1020

acatgtattt ggatgtctag atgaatgtct tattatagcg gcagctcttt ctttgaagaa     1080

tttttttgca atgcctttcc ggcagcatct cgatggatat aggaacaaag tgaatttctc     1140

tggcagtagc aagagtgact gtattgcact tgttgaggca tttaaaacat ggaaggcttg     1200

cagacagaca ggggagctgc ggtacccgaa ggatgaactt aattggggac ggttaaatta     1260

cattcaaatc aagagaatta gagaggtggc tgaattatat gaagaattga agactagaat     1320

ctcacagttc aacatgcatg ttgattctcg gcgacctgtc atggaccaag agtatatata     1380

taagcagcga ttcatcctac aggttgtatt ggcaggtgct ttctatccaa attactttac     1440

ttttggacag ccggatgagg agatggcggt gagggagctg gctggcaagg accccaagac     1500

aactgtcgtg ttgaaacaca ttcctcccta tggatttctt tactataaac aactacagtc     1560

tctctttaga cagtgtggtc aagtcaaatc cattgtattt gatggtgcaa aagcctttgt     1620

ggaattctca cgaaatccaa cagagagatt taaaaccctt cctgcagtat atatggcaat     1680

taagatgtct caactaaaag tttcacttga actcagcgtt cattctgcag aggaaattga     1740

agggaaggtg caaggcatga acgtctcaaa gctcaggaac acaagggtga atgtggactt     1800

ccagaagcag acggtagatc ctatgcaagt ctcctttaac acatcagaca ggtcccagac     1860

agttacagat ctccttctaa ctattgatgt cacagaggtg gttgaagtgg gacacttttg     1920

gggatacagg attgatgaaa acaactcaga gattctgaaa aagcttactg ctgaaatcaa     1980

ccaactgacg ctggtgccct tgcccactca cccacatcca gacttggtct gtctggcacc     2040

ttttgctgat tttgataaac aacgctactt tagagctcaa gtcctttatg tttctggaaa     2100

ttctgctgag gtattctttg tagattatgg caataagtct catgtagatc tacatctttt     2160

gatggagatt ccctgtcaat ttcttgaact tcctttccag gctttggaat ttaagatttg     2220

caaaatgaga ccatcagcaa agtctcttgt ttgtggcaag cactggagtg acggggccag     2280

ccagtggttc gcctctctgg tgagcggctg caccctcctt gtgaaggtct tctctgtggt     2340

gcacagcgtc ctgcacgtgg atgtgtacca gtactcaggg gtccaggatg ccatcaacat     2400

aagagacgtc ctcatccagc agggctatgc cgagctcacg gaggagtcct acgagtccaa     2460

ggttaatatt ctcagggctg ctattaacaa gctagtctgt gatggaccaa atggatgcaa     2520

gtgtcttggg ccagagagag ttgcgcagct tcaagacatt gcccgtcaga agcttttagg     2580

tttgttctgt cagtcaaaac caagggagaa gattgttccc aagtggcatg aaaagcccta     2640

cgagtggaat caggttgatc caaagctggt catggagcag gccgaccgtg agagcagcag     2700

agggaagaac acctttctct accagctcca caaactggtt gtgctcggca cctgagcatg     2760

tccacaggtg gcctccagca cacccctcag gaagctgtgg aggctggatt ccaggctccc     2820

tccgcagact gactttcctc tgtgtctggg tgttacagtc tgtgcccact gcatcctaaa     2880

ggccttttct ttcttctttt ctctttgggt gatagtcaga gagtggtgtt tttgttcagg     2940

tgggaaggat tggaaactct agtcttttct agaaacagaa aatcactgta ttaaatattt     3000

tggaaagatt gttctgaaag aagtctgttt ggataaagag ctgtattttg ctttaaattt     3060

attaaggtaa atataagtag ttaatcttag atgtaaggtt ccagaatgtg cttacatatt     3120

ctgttctgtt acagtgattt aaaccagtag tataggaaaa aacttaaaaa aacaaaaaaa     3180

ccatgtagta ttttctgatt tttttttcca tgagggaaaa tatctaattt ttataagact     3240

aagttgagtt atacttcttg gttcacattt tggaaatcag agattacaga ttacatggcc     3300

atagcttatc tgtgttaaaa caataaaagc attaaatg                             3338


<210> 4614
<211> 649
<212> DNA
<213> Homo sapiens

<400> 4614
gcggcgccgg gcttcccacg gacggggccc cgcggggttg cccggccgtg cccgctgtgc       60

ccggctctgc ccggcgcggc cgcggagcgc acgcctcctg cctgctgacc ctctcgtttg      120

gtttctcgca ggcctctgcc gcagacatgg agaaactcag cgcgctgcag gagcagaagg      180

gcgagctgcg caagcggctg tcctacacca cacacaagct cgagaagctc gagaccgagt      240

tcgactccac gcgccactac ctggagatcg agctgcggcg cgcgcaggag gaactggaga      300

aggtcacgga gaagctgcgc aggattcaga gcaactacat ggcactgcag aggatcaacc      360

aggagctgga ggacaagctg taccgcatgg gccagcacta tgaggaggag aagcgtgcgc      420

tgagccacga gattgttgcc ctcaacagcc atctgctaga agccaaggtg accatcgaca      480

agctgtcaga ggacaacgag ctctatagga aggactgcaa tctagcggcc cagctgctgc      540

agtgcagcca gacctacggc agggtccaca aggtgtctga gctgccctcg gatttccagg      600

agcgcgtgag cctgcacatg gagaagcacg gctgcagcct gccatcccc                  649


<210> 4615
<211> 878
<212> DNA
<213> Homo sapiens

<400> 4615
cggccgctcc ttggtcgcgg tcactccagg ctgcctcgct gcgccgctgg cggtgggcgt       60

ggcgctgccg gcggctaggc gcggacgccg gaggaggtgt ccccgggttt aggggtgttc      120

ggccaggggc ggggctgccg ggcccgggcg actgccggag ctgcggaagt cgtggaagcg      180

tcggcgacgc atcgcgcgat ggcgcgggcg ggacagtgct tgtgaaactg aacacaacaa      240

aagtatggat atgggaaacc aacatccttc tattagtagg cttcaggaaa tccaaaagga      300

agtaaaaagt gtagaacagc aagttatcgg cttcagtggt ctgtcagatg acaagaatta      360

caagaaactg gagaggattc taacaaaaca gctttttgaa atagactctg tagatactga      420

aggaaaagga gatattcagc aagctaggaa gcgggcagca caggagacag aacgtcttct      480

caaagagttg gagcagaatg caaaccaccc acaccggatt gaaatacaga acatttttga      540

ggaagcccag tccctcgtga gagagaaaat tgtgccattt tataatggag gcaactgcgt      600

aactgatgag tttgaagaag gcatccaaga tatcattctg aggctgacac atgttaaaac      660

tggaggaaaa atctccttgc ggaaagcaag gtatcacact ttaaccaaaa tctgtgcggt      720

gcaagagata atcgaagact gcatgaaaaa gcagccttcc ctgccgcttt ccgaggatgc      780

acatccttcc gttgccaaaa tcaacttcgt gatgtgtgag gtgaacaagg cccgaggggt      840

cctgattgca cttctgatgg gtgtgaacaa caatgaga                              878


<210> 4616
<211> 4803
<212> DNA
<213> Homo sapiens

<400> 4616
tggaggggag aaagaggaag ggctgcggcc gcggaaggct ggggtcggtg accggccggt       60

tatctctggc tcggtggtga cttagggtct gggtctccgc agacgatttg tgtttgggca      120

aggcattcgt ctaccgacac acccacagcc tacagtgagg gagtgtgggt gaggggattt      180

ctctcccact tccgactctc cctagagtct caggatgggg gctgaggacc gaggcgtggg      240

agtgcgattt gacaatggag tgatgaaggc tttccttaaa gtttcccatg tctcaatgga      300

ctcctgaata taacgagctc tacaccttaa aagtggatat gaagagtgag attccttctg      360

atgcaccaaa gacacaggag agtctgaaag ggatcctttt gcatccagag cccattgggg      420

cagccaaaag ttttcctgca ggagttgaga tgattaatag taaagtgggg aatgaattct      480

ctcacctgtg tgatgattct caaaagcaag agaaggaaat gaatggtaac cagcaagaac      540

aagaaaaaag tctcgttgtg aggaaaaaac gcaaaagcca gcaggctggc ccttcgtatg      600

tgcagaattg tgttaaagaa aaccagggaa tattaggact gaggcaacac ctagggacac      660

caagtgatga agataatgat tcctctttta gtgattgtct ttcttctcct tcatctagtc      720

tgcattttgg agattctgat actgtgactt cagatgagga taaagaagtc tctgtaagac      780

attcccagac cattttgaat gctaaaagta gaagccatag tgcacggtct cataagtggc      840

ctcggactga gacagaatct gtatcgggat tgttaatgaa aagaccctgt ttacatggca      900

gttcgttacg gagacttcca tgcagaaaga gatttgtaaa aaataattcc tcacagagga      960

cacagaaaca aaaagagagg atattaatgc agaggaagaa acgagaagtg ttagctcgaa     1020

gaaaatatgc cttgctacct agttctagta gttccagtga gaatgacctc agcagtgaat     1080

cctcttctag ctcatcaact gaaggagaag aagatttgtt tgtttctgcc agtgaaaacc     1140

accaaaacaa tccagctgtt ccctcaggaa gtattgatga agatgttgtg gtgatagaag     1200

cttcctccac tccccaggtt actgccaatg aagaaattaa tgttacctca actgacagtg     1260

aagtggagat tgtaacagtt ggagaaagct atcggtctcg ttcaaccctt ggacactcca     1320

gatctcattg gagccagggt tccagttctc atgcaagtcg gccacaggag ccacggaacc     1380

gcagtaggat ttctactgtt atacagccct tgaggcagaa tgcagcagaa gttgtggacc     1440

ttaccgttga tgaagatgaa cctactgtag taccaaccac ttctgcaaga atggaatcac     1500

aagctactag cgcttccatt aacaattcaa atccatctac ctctgagcag gcctctgata     1560

ctgcttcagc tgtcaccagt agccaacctt ccacagtgtc agagacttca gctactctta     1620

caagcaatag taccactggc acttctatag gagatgactc aaggagaact acatctagtg     1680

ctgtaacgga aactggccct cctgcaatgc caaggttacc ttcctgctgt ccccagcact     1740

caccatgtgg agggtcgtca cagaaccacc atgcattagg acatcctcat acaagttgct     1800

ttcagcagca tggtcaccat tttcaacatc atcaccacca ccaccatact ccccacccag     1860

ctgtcccagt ttctccttcc tttagtgatc ctgcttgccc tgtggaaaga cctccacaag     1920

tacaagcacc ttgtggagca aatagtagtt ctggtaccag ctatcatgaa cagcaggcat     1980

tgccagtgga cctgagcaac agtggtatca gaagtcatgg aagtggcagt tttcatggag     2040

catctgcatt tgacccctgc tgccctgttt cttcctcccg agctgcaatc tttggccatc     2100

aggccgctgc tgctgcccca agtcaacctt tatcatcaat agatggctat ggatcaagca     2160

tggttgcgca gccccagccc cagccccctc cacagccctc tctctcatca tgtcgacatt     2220

acatgccacc cccttatgcc tctttgacaa ggccacttca tcatcaagct tctgcctgcc     2280

cgcattctca tggaaacccc cctcctcaga ctcagcctcc gcctcaagtg gattatgtta     2340

ttcctcatcc tgtacatgct ttccattctc aaatatcttc tcatgcaaca tctcatcctg     2400

tggcaccccc accaccaact cacttagcca gtacagctgc accaatccct cagcatcttc     2460

ctcctacaca ccagccaatt tcgcaccata ttccagccac agcacctcca gcacagagac     2520

tgcatcctca tgaagtgatg cagaggatgg aagttcaaag gaggaggatg atgcagcatc     2580

caacgcgggc acatgaacgc cccccacccc atccacatag gatgcaccca aactatggtc     2640

atgggcatca tattcatgtg cctcagacta tgtcctcaca tcctcgacag gctccagaga     2700

ggtctgcctg ggaactggga attgaagctg gagtgactgc agctacttat acacctggtg     2760

cattgcatcc tcacttggcc cattatcacg cacctcctcg acttcatcac ttacaattag     2820

gagctcttcc tttaatggtt cctgatatgg caggctatcc tcacatccgt tacatttcat     2880

caggattgga tggaacatca ttcagaggtc ctttcagggg caattttgag gaactgattc     2940

atttggaaga aagattaggc aatgtcaatc gtggagcatc ccaggggaca attgaaagat     3000

gtacatatcc acataaatac aaaaaggtaa caactgattg gttctcacag aggaaactgc     3060

actgcaaaca agatggggaa gaagggactg aggaagacac agaggaaaaa tgtactatct     3120

gtttgtctat tttagaggaa ggtgaagatg tgagacgtct tccatgtatg caccttttcc     3180

accaagtgtg tgttgaccaa tggttgatta ccaataagaa gtgccccata tgcagagtgg     3240

acattgaggc ccagctgcca agtgaaagtt gacaccatgt ttcagaactc ttgccctccc     3300

tctcattccc atccttcctg gtactgcagt caaccaaaga tggcatgact tacctgcgca     3360

gatttggaag cattgaactt agagtgctgg ctctgctata tggtacaact aatgctagac     3420

ctacagttta tgtatacagt tgattttgat gtatttataa aagctttttt ttctagattt     3480

gacatttttc tgtatcattt tactgtattt ttgcatggtt ccttgtattg catttctttg     3540

cacatattat gggcttgtga ccctaaactt gcaggcaagg ttagctgctt tagtaagtag     3600

aattttgtgg tctttttgtt ttttacatag taccaagcct tgataattat gaatttttta     3660

tccattacta acctttaatt taatcaatca tgtactttag tttaatgtat aaagatcctc     3720

tagaaaatga taatattgtg tattaagaca ttccttaatt aggacaaaat ggctgctgta     3780

tatttactat atggagttct gagttaaata ccatccttaa tactgggaac agaatacaac     3840

ccatataaat cagatgcagg tggtagtcac atcaccagag tgatcagtat aaattttctt     3900

ggtgtatcct tttcctttca acacagtgca gataagagtt gaatattgat atcatacatt     3960

tagactgctg ttctgattgc atttatcttt ttcctacatc atttagaatt ttatttccct     4020

gattcagttt ttgctgctgt gaaacagctc tgatgaacac taaatattaa tttcaattag     4080

ctagattgta catacttgca gatttaacaa aattttaggg aaattgaaaa agacatgtag     4140

aatttgttgt cttctgctaa gcacgaaaag ttaagatatc tgcttacatt gattttgtag     4200

acacattaag tcaagatttg gaatttaagt cactggcagg tatctgtgca ttcatagaac     4260

ttataaaggt cccaggatca cttttaaggg atttttatta gtttaaaggt aaataaagtc     4320

agctgaatct acatgtctct tgttttattt ctctctaaac ttgaaaacag taaatctgca     4380

gatactgtga ggcacaaatt atactgtcaa cctactgttg ctatggttat atactcccac     4440

ttcatacatt accaagagtc gatcactgat ttaaaatttt taatttctat agttaagatt     4500

tactgcataa tatagaatat aaagttaagt taacatacta acatttctcc tttggaggaa     4560

gttttaatct acttcaggat gcatattatt atcaagatac tttcatatac aggatagcct     4620

aattttattt gtttaaatat gcttaatatg ccccagattg caaatgcatc cagtcagtaa     4680

tatcactgtc tgtatgtgga ggacatgttc ccatggatca tatgtgaaga tgtcaataag     4740

cttgcattaa gccacctgct ttgtaagtgg attgattaat aaataactta tatttctatt     4800

gtc                                                                   4803


<210> 4617
<211> 1595
<212> DNA
<213> Homo sapiens

<400> 4617
ctccccaggg ccaggcgtcc cgcgcacctg gtactcggcc agcagctcct tggacaggcg       60

actgcccgag ccccccatcg ccccgccgcg cgcacagctc cgccaactcg cctcgagacg      120

cagacaactt tctcacttcc gcccttgggc cgcgtcactg cccggtcccc gcggcaaccg      180

ctcctggggc caccaccccc gggcccgccc cctcctaaaa gctgccaggc gttcccagcc      240

gggtttggca ggcgagctgc cggctccaag cggtcctagg ctatttactg aggacccact      300

ggatgtcaag cattgtgcat agttttcttc gattgttgca acatcccttg cgagtttctg      360

gagcagcaga gctgaaggaa cccaaacttg gactgaagtg actctactaa ggtcagctct      420

atggctcttc cacatgattc aaacgaaact tcctatttgc tgcctcccaa caatgaggac      480

tggggcaggc aaaccattcc tgactttgtt tatgggcaga aggatctcat ggcagaaggg      540

attcagtggc caaggaatgc acctggcatc ccagatgctc tgccacaatc tccctttgat      600

gctgcactct gctctgcctg gaagcagcgg gtggagctgg ggctgtttcg ctaccgtcta      660

cgggagctac agacccaaat cctccctggt gctgtgggtt tcgtggctca gctgaatgtg      720

gagcgtggtg tgcagaggag gcccccgcag accatcaaga gtgtgaggca ggcatttgac      780

cctgtacagt tcaacttcaa caagatccgg cccggagaag tcctcttccg tttgcaccgg      840

gagcctgatc tccctgggac tctgctgcaa gaagacatcc tggtggtgat caacgtcagc      900

cccctggagt ggggccacgt gctgctggtg cctgagcctg cccgccagct cccccagcgc      960

ctgctgccgg gtgcactgag ggcagggatt gaggctgtgc tgctgagctt acacccgggc     1020

ttccgtgtcg gcttcaacag cctgggaggc ttggcctcgg tgaaccacct ccacctgcat     1080

ggctattacc tggcccacag actgcccgtg gagcaggcgc caagcgagcc cctggaccct     1140

ggaggccatt tgcatctgct ccaggacctc ccagctcctg gcttcctctt ttacactcgt     1200

gggccagggc ctgacttgga gtccttgata agcagggtat gtcgggccac tgattatctg     1260

actgaccatg agattgctca taacttgttt gtcacccggg gagctccgcc gggaaagaca     1320

tcaccttcct cagccctcac aggggtccga gtaattctgt gggcccggaa gtccagcttt     1380

gggataaagg acggtgaagc tttcaatgtt gccctctgtg agctggctgg gcacctccct     1440

gtcaaaacat cccaggactt cagcagcctg acagaggcag ctgctgtggc cctcattcag     1500

gactgtcggc tgcccccatc ccaggcagaa gacgtacagg cagcactggt ggccctgatg     1560

tcccaggaag agcaataata cttctggatg tattt                                1595


<210> 4618
<211> 8456
<212> DNA
<213> Homo sapiens

<400> 4618
gcgaggaaga agaggacgac gacgacgagg aagaggaggt ttctgaggtg gagtctttca       60

ttttggatca ggatgatttg gaaaatccaa tgctggaaac agcttccaag ttgctcttat      120

caggtactgc tgatggtgca gacctcagga cagtagatcc agaaacacag gctagactgg      180

aagctttact agaagctgca ggaataggaa aattgtccac ggctgatggt aaagcctttg      240

cagatcctga agtacttcgg aggttgacat cgtctgttag ttgtgcgttg gatgaagctg      300

ctgctgcact tacccgtatg agagctgaaa gcacagcaaa tgcagggcag tcggacaacc      360

gcagtttggc agaagcctgt tcagaaggag atgtaaatgc tgtgcgaaag ttactcattg      420

aagggcgaag tgtaaatgaa cacacagagg aaggggagag cctcctttgt ttagcttgtt      480

ctgctggata ctatgagctt gcacaggttt tgttggcaat gcatgcaaat gtggaagata      540

ggggaatcaa aggtgacatt acacctttaa tggctgctgc taatggagga catgtcaaaa      600

ttgtgaagtt gctgctagct cataaagcag atgttaatgc acagtcttca acaggcaata      660

cagcacttac atatgcttgt gctggaggct atgtagatgt tgtaaaggtg ctcttggaat      720

ccggtgctag tattgaggac cataatgaaa atggtcatac ccctcttatg gaagctggaa      780

gtgctggaca tgtggaagta gccagattgc tgctagaaaa tggggctggc attaatacgc      840

attctaatga atttaaagag agtgccctta ccttagcttg ttacaaagga cacttagaga      900

tggtgcgatt tcttttggaa gcaggcgcgg atcaagagca taaaacagat gaaatgcaca      960

ctgctctgat ggaggcttgc atggatggcc atgttgaagt agctaggtta cttcttgaca     1020

gcggtgccca agtgaacatg cctgctgatt catttgagtc accattaact ttggctgcat     1080

gtggtgggca tgtggaactt gcggctttac ttattgaaag aggagctagc ctggaagagg     1140

tcaatgatga aggttataca ccattgatgg aagcagctcg agaaggacat gaagaaatgg     1200

tggcattact tcttggtcaa ggagcaaata tcaatgcaca gacagaagaa actcaagaaa     1260

ctgccttgac tctggcttgc tgtggaggct ttctggaagt ggcagacttt ctaattaagg     1320

caggagccga tatagaacta gggtgttcta cccctttaat ggaagctgct caagagggtc     1380

atttggagtt agttaaatac ttattagctg caggagctaa cgttcatgca acaacagcaa     1440

caggggatac agcactaaca tatgcctgtg aaaatggtca tactgatgta gcagatgtct     1500

tacttcaggc aggcgcagat ctggaacatg aatctgaagg tggaagaact cctttaatga     1560

aagctgcaag agctggtcat gtttgtactg ttcagttctt aattagtaaa ggagcgaatg     1620

tgaatagaac cacagctaat aatgaccata ctgtactgtc cctggcttgt gcagggggtc     1680

atctggcagt ggtggaacta cttttggctc atggggcaga tcctactcac cgtttgaaag     1740

atggctcaac tatgttgata gaagcagcaa aaggtggcca tacaagtgtt gtttgctatc     1800

tcttggatta tcctaataac ttgctttcag cccctccacc agatgtcact cagttaactc     1860

ccccatccca cgatttaaat agggctcctc gtgtaccagt tcaagcactg cccatggttg     1920

ttccacctca ggagcctgac aaaccacctg ccaatgttgc caccactctt cccatcagga     1980

ataaagctgc ttctaaacaa aagtccagca gccatttgcc agcaaacagc caggatgtac     2040

agggttacat caccaatcag tctccagaga gcattgtaga agaggctcag ggaaagttaa     2100

cagaactgga acagaggata aaagaagcca tagaaaagaa tgcacagctg cagtccttgg     2160

aactggctca tgctgaccaa cttaccaagg agaagatcga ggagctcaac aaaacaaggg     2220

aggaacaaat tcagaagaaa caaaagattt tggaggaact acagaaagta gaacgagagt     2280

tacaactgaa aactcagcag cagctaaaaa agcagtatct agaggttaaa gctcaaagaa     2340

ttcaacttca gcaacagcag caacagtctt gccaacacct gggattacta actcctgttg     2400

gagttggaga gcagctttct gagggagact atgcacggtt acagcaagtg gatcctgttt     2460

tacttaaaga tgaaccccag cagactgctg ctcagatggg ttttgcgcca atccagcctc     2520

tggcgatgcc tcaagctttg cctctggcgg caggtccctt gcctccaggg tccatcgcaa     2580

atcttacaga actgcaagga gtgatagttg gacagccagt actgggccaa gcacagttgg     2640

cagggctggg gcaaggaatt ctgacagaaa cacaacaagg gttaatggta gccagccctg     2700

ctcagaccct caatgacacg ctggatgaca tcatggcagt cagtggaaga gcatctgcaa     2760

tgtcaaacac tcctacccac agtattgctg catccatttc ccaacctcag actccaactc     2820

caagtcctat catctctcct tcagccatgc ttcctatcta ccctgccatt gatattgatg     2880

cacagactga gagtaatcat gacacggcac taacacttgc ctgtgctggt ggccacgagg     2940

aactggtaca aacactgcta gagagaggag ctagtataga gcaccgagac aagaaaggtt     3000

ttactccact catcttggct gccacagctg gtcatgttgg tgttgtggaa atattgctgg     3060

acaatggtgc agacattgaa gcccagtctg aaagaaccaa ggacacacca ctctccttgg     3120

cttgttctgg gggaagacag gaggtggtgg agctattgtt agctcgaggg gcaaataaag     3180

agcacaggaa tgtttctgat tacacacctc taagtctggc tgcttctggt ggctatgtga     3240

acatcatcaa aatattacta aatgcaggag ctgagattaa ctctagaact ggtagcaaat     3300

tgggcatctc tcctctgatg ttagcagcta tgaatgggca tacagctgct gttaagctcc     3360

tgttagacat gggctctgac ataaatgctc agatagaaac caatcggaac actgccctta     3420

ctttagcctg cttccaagga agaactgaag tggttagtct tctgcttgat agaaaagcaa     3480

atgttgaaca cagagctaag actggtctca caccactaat ggaagctgcc tctggtggat     3540

atgcggaggt gggccgagtt cttttggata aaggtgctga tgttaatgcc cctccagttc     3600

cctcctcaag agatacagct ttaaccatag cagcagataa agggcattac aaattctgtg     3660

agcttcttat tggcagggga gctcatattg atgtacgtaa caagaagggg aacactccat     3720

tgtggctagc agcaaatggt ggacacctcg atgtggttca gttactggtg caagcaggtg     3780

cagatgtgga tgcagcagat aaccgcaaga taactcctct tatggcagca tttagaaagg     3840

gtcatgtgaa ggtggtgcgc tacttagtca aagaagtcaa tcagtttcca tcagattctg     3900

aatgtatgag atacatagca accatcactg ataaggagat gctgaagaag tgtcatcttt     3960

gtatggagtc aatagtacaa gccaaagata gacaggctgc tgaagcaaac aaaaacgcca     4020

gcattttgtt agaggagtta gacttggaaa agttaaggga agaaagtcgg aggctggctt     4080

tggctgcgaa aagagaaaaa agaaaagaga agagaaggaa gaaaaaggaa gaacaaagaa     4140

ggaaactaga agaaattgaa gccaaaaata aagagaactt tgaactccaa gctgctcaag     4200

aaaaagaaaa gcttaaagtt gaagatgagc ctgaagtctt gacagaacct ccaagtgcca     4260

caaccactac taccataggt atatctgcaa cctggacaac tttggcaggt tctcatggta     4320

aaagaaataa taccataact acaaccagtt caaagaggaa aaacaggaaa aataaaatta     4380

ctccagaaaa cgttcaaatt atatttgatg atccactacc aatttcatac agtcagccag     4440

agaaggtgaa tggagagtcc aagagcagca gtaccagcga gagtggggac agtgataaca     4500

tgaggatttc cagctgcagc gatgaaagta gtaacagcaa cagcagtcgt aagagtgaca     4560

atcattcacc agctgtggtc actaccactg tgagcagcaa aaagcagcca tcagttcttg     4620

ttacatttcc aaaggaagag agaaaatctg tttctggcaa ggcttcaata aaattgtcag     4680

aaactatcag tgaagggacc agtaattctc tatctacttg tacaaaatct ggtccatctc     4740

ccctttcttc tccaaatggg aagttaacag tagcaagtcc taagcgtggg caaaagaggg     4800

aagaaggatg gaaagaagtt gtaagaaggt caaagaaagt atctgttcca tcaactgtga     4860

tatccagagt gattggaaga ggaggctgta atatcaatgc tattcgggag tttactggtg     4920

cacacataga tattgataaa cagaaagaca agactggaga ccggataatc actataaggg     4980

gtggcactga atcaacaaga caagcaactc aattgattaa tgctttgatc aaggatccag     5040

acaaagaaat tgatgaactt attccaaaga atcgtttgaa aagctcctca gcaaattcca     5100

aaatagggtc atcagcacct accaccactg ctgctaacac ttccttaatg ggaattaaaa     5160

tgacaactgt agctctgtca tcaacatctc aaactgccac agcactcact gtgcctgcaa     5220

tttcttctgc atccactcac aaaaccatta agaacccagt gaataatgtg aggcctggtt     5280

ttccagtttc tcttccatta gcatatcctc ctccacagtt tgcacatgct ttgcttgctg     5340

ctcagacttt ccagcagatc cgtccaccaa ggttgcccat gacccacttt ggaggtactt     5400

ttccaccagc tcaatccact tggggtccgt ttcctgtcag gcctttgagc cctgccagag     5460

ctactaactc gcctaagcct cacatggtgc ctcgccatag caatcagaat agcagtggtt     5520

ctcaggtgaa ttcagcaggt tctttaactt caagcccaac aactacaacc agttcatcag     5580

cttcaacggt gcctggtaca tctacaaatg gcagtccaag ttcaccttct gtccgaaggc     5640

agctttttgt cacagttgtg aagacatcca atgccaccac aacaacagtc acaaccacgg     5700

caagcaacaa caacactgca cccacaaatg ccacatatcc tatgcctact gccaaagaac     5760

actatccagt atcatcccca tcttccccat caccaccagc ccagccagga ggggtttcta     5820

gaaacagccc tttggattgt ggatcagcat ctccaaataa agtggcatct tcctccgaac     5880

aggaagcagg tagtccacca gtagtagaaa caacaaacac tagacctcca aacagcagca     5940

gttcttctgg gagttcatca gctcattcta atcagcaaca acctccggga tctgtttctc     6000

aggaaccaag accacctctt cagcagtctc aggttcctcc cccggaagtt agaatgactg     6060

ttcctccttt agcaacaagt tctgctccag tggcggtgcc ttctactgcc ccagtgactt     6120

accctatgcc tcagacacca atgggatgcc cccagcctac tcctaaaatg gaaacccctg     6180

ctattagacc accccctcat ggcacaactg cccctcacaa gaattcagct tcagtgcaaa     6240

attcatctgt tgcagtcctc agtgtcaatc acattaaaag acctcacagt gttccctctt     6300

ctgtccagct accttcgacc ttaagtacac aaagtgcttg tcagaattca gtacatccag     6360

caaataagcc tattgctccc aatttcagtg cccccttacc atttgggccc tttagcacat     6420

tgtttgaaaa cagccctact tctgctcatg ccttctgggg aggatctgtt gtttcatctc     6480

agtcaacacc agaatctatg ctatcaggaa aatcctcata tttgccaaat tcagatcctt     6540

tacatcagtc tgatacttcc aaagctccag gttttagacc accattacag agacctgctc     6600

caagtccctc aggtattgtc aatatggact cgccatatgg ttctgtaaca ccttcttcaa     6660

cacatttggg aaactttgct tcaaacattt caggaggtca gatgtacgga cctggggcac     6720

cccttggagg agcacccgca gctgctaact ttaacagaca acatttttcc ccgcttagtt     6780

tgttgactcc gtgttcatca gcatcaaatg attcttctgc acagtcagta tcctcgggag     6840

ttcgtgcacc atctcctgcc ccatcatcag taccgttagg gtcagaaaag cccagcaatg     6900

tgtctcagga caggaaagtt ccagtcccta ttgggactga acgttctgca cgtatcaggc     6960

aaactggaac gtcagctcca tctgttattg ggagcaattt gtctacatca gtaggacata     7020

gtggcatctg gtcctttgaa gggattggtg gcaatcaaga caaagtagac tggtgtaacc     7080

ctgggatggg aaatcctatg atccacagac cgatgtctga cccaggagta ttttcacaac     7140

atcaagcaat ggagcgagat agtacaggaa ttgtaactcc ttctggtaca ttccatcagc     7200

atgttcctgc aggctacatg gactttccta aagttggggg tatgcctttt tctgtgtatg     7260

ggaatgcaat gattcctcca gtagcaccta tccctgatgg tgctggagga cccatattta     7320

atggccctca tgctgcagac ccttcttgga actcactgat aaagatggtt tccagctcca     7380

cggaaaataa tggccctcaa acggtgtgga ctggaccctg ggcacctcac atgaacagtg     7440

tgcatatgaa ccagcttggc tgatgaggat cagcttgtta gcctgcagat tccttttcat     7500

ttggaggaaa tcacaagtgg ccgaaaaaaa aaattatgct cccaaatcat tctactgatg     7560

tgcttgactg aagtgtgtag gctttttgca gaagatctta ctaactgacc tattttctgt     7620

gaacatttgt gactgcccat tccccatcat catccgtttt accttagtta gcatttttct     7680

tatcattttt ctttttttct ttccctcttc ccctttggac ataactttct gttgaagctg     7740

ttctttggct ggttggtttt agtactgtaa actgcttctg agcaaacacg gaaatttagc     7800

aaaattatgt aaacttgatc ctgaagtttt agaatggcaa ataaatgtac aattgtttac     7860

ataacagaaa aggctaagca gaaagtaaat ttcaatatgt cagtatagag gctctacttt     7920

atgtagactt aaattaatgt gagatatgta ccttcatatt cagaaatctg gatgtttcct     7980

tcatacatta aactattaat aagcataact tttctactgg tgtaatttaa gtataaagta     8040

aaataatggg cattatcatt ggatgtttcc ccacattggc ttttaaaata cccatcttgc     8100

tttctttttg gtttatttgt agcaaggcac atatagaaga agaaatttct ggcttttcca     8160

tgttgtttta ttaccttttc tcacttttaa aactaataca gacttatctc ctcactcctt     8220

tttctctcct tacctttacc actaatacca gtaaaattat ctttctgata gtgaaaaggt     8280

tctgtcaaga ttttcactgt aatggctgct acagagatgg accatcttca tcatcaccag     8340

tggtttcttc taattataaa atgtttaaac tttctgagaa tttaaaaagc caccactgtt     8400

cccagtcagc atatacaagc tcttaatatt ctgtttatta aataattcaa tgtact         8456


<210> 4619
<211> 550
<212> DNA
<213> Homo sapiens

<400> 4619
aagtcgcgag gtgcatccgc ttcggctgca gtaggtggtg gcggcggcag ccctgggtgg       60

ggtcccatag gggcatctga gaagtcactg gagctagcgt ttccgggaaa cctggagact      120

cgctgagtgg cgggggtcgt cggctgcccc tctgcccagc aagggctttt ctagatgtta      180

tcatcaggca atcgctgcac ctgtcgcagc ccccaagcca cctcttccag aagtaaccat      240

aaccttgctt ccttcttagg ctatttactg aggacccact ggatgtcaag cattgtgcat      300

agttttcttc gattgttgca acatcccttg cgagagtttc actcctgttg cccaggctgg      360

agtgcaatgg catgatctca gctcaccgca acctccgcct cctgagttca agcagttctc      420

ctgcctcagc ctcctgaata gctcggatta cagtttctgg agcagcagag ctgaaggaac      480

ccaaacttgg actgaagtga ctctactaag gtcagctcta tggctcttcc acatgattca      540

aacgaaactt                                                             550


<210> 4620
<211> 581
<212> DNA
<213> Homo sapiens

<400> 4620
agcaaaaata aaggacgcga ccgccgcagc ctctgcggag ccgggctcgg gtcgccggag       60

ccgcgcccca ccccgccagc tccagagcca cgtacggact aatggctgaa ggataaatca      120

acatggcaac tatgattcca ccagtgaagc tgaaatggct tgaacacttg aacagctcct      180

ggattacaga ggacagtgaa tctattgcta caagagaggg agttgctgtt ctgtattcta      240

aactggttag caataaggaa gtagtacctt tgccccaaca agttttatgc ctcaaaggac      300

cacagttgcc agactttgaa cgtgagtctc tttcaagtga tgagcaggac cactatttgg      360

atgcccttct tagcagccag ctagcattgg caaagatggt atgttcagat tccccatttg      420

ccggggcact tagaaaacga ctgcttgtac tccagcgtgt cttttatgca ctttctaata      480

aataccatga caaaggcaag gtgaagcagc agcagcattc tccggagagc agttctggtt      540

cagcagatgt ccattctgtt agtgaacgcc cccggtcaag c                          581


<210> 4621
<211> 411
<212> DNA
<213> Homo sapiens

<400> 4621
tgcgggagga gaggtttggg aggcgcggga gatgtccacc ctgggctggt ggcgccgccg       60

ggcgccgggc gccatgaggg tgcgctaggc ggctgttcgt gcccgaggct gcgcagcact      120

gaggtgagct ttgccttctt gatcttccgt ccttcttgga gacgactggc gagaggaaga      180

gggactaggt ccaaacgcta ggtggctggg tccaggtccc tgagtactga cggtcacagg      240

ctgccgcgtc tttcctgttg actcatgttt ggttcctcca gtgaaaattt tacttagaga      300

aatgctgcct ccaaagcact tgtctgccac caaacctaag aagtcctggg ccccaaatct      360

gtatgagcta gacagtgact tgactaagga gccggatgtc atcataggag a               411


<210> 4622
<211> 1083
<212> DNA
<213> Homo sapiens

<400> 4622
cggcgtgagg accccggcgg cgccgcagtc ccgcgagcca tggcccagtc cggcggggag       60

gctcggcccg ggcccaagac ggcggtgcag atccgcgtcg ccatccagga ggccgaggac      120

gtggacgagt tggaggacga ggaggagggg gcggagactc ggggcgccgg ggacccggcc      180

cggtacctca gccccggctg gggcagcgcg agcgaggagg agccgagccg cgggcacaga      240

actgcccagc tcccgtggct tgagtctcag caagtgttca gtctgaagcc cttcctgctg      300

cccactggca tagagttgac cccagaaaat ccctggggtt cttcggtgag ctgacagagc      360

ccagtgggca ggcacccaga gcaggaggag atgtagccaa gaacaggatc cacactatcc      420

cctgtttgga cccaggctcg catggcagca gccatcaccc gatgtgaatg ttctcagctc      480

ctggagccta caggagaaaa cccagattcc tcaatctgct cattaagatg tgacacccac      540

tcacatcatc tcctcagccc attgcctcaa cagttcacgc tgtcaacagt tcacgctccc      600

gtgattccag ctagttccct gagcataggg ggctattttg tgtctacatg cctctgcacc      660

cccacctcta ggtcctctga ttgactgatt tctagtcagc ctttaaaact tcgctgcctc      720

ttctccacca cccccaatcc ccaccccaga gctggctgtg tttcctttct tctctgttgc      780

tgtagtactc tgtacatttt atgcctagca ccttccacaa ttgtgattct atcattgtgt      840

ctccctcaca ggaataggag ctcggtgaat tcaaggacca tgcttgcttc gttcattgta      900

tcttcagcac ctagcacagc acccagcaca taggacatgt ttgttgactg aatgcgtatc      960

tctatcatca cactcactca atggtgttga gatatttgtg tttccccttc cctagacagt     1020

gagatccttg aaggcagctg ccttatctta ttcctttttg tatttccata cctagcctaa     1080

tac                                                                   1083


<210> 4623
<211> 850
<212> DNA
<213> Homo sapiens

<400> 4623
catgacctcg ctgtggcccc ggcagcggct gcggggaaag tcgcgaggtg catccgcttc       60

ggctgcagct atttactgag gacccactgg atgtcaagca ttgtgcatag ttttcttcga      120

ttgttgcaac atcccttgcg agtttctgga gcagcagagc tgaaggaacc caaacttgga      180

ctgaagtgac tctactaagg tcagctctat ggctcttcca catgattcaa acgaaacttc      240

ctatttgctg cctcccaaca atgaggactg gggcaggcaa accattcctg actttgttta      300

tgggcagaag gatctcatgg cagaagggat tcagtggcca aggaatgcac ctggcatccc      360

agatgctctg ccacaatctc cctttgatgc tgcactctgc tctgcctgga agcagcgggt      420

ggagctgggg ctgtttcgct accgtctacg ggagctacag acccaaatcc tccctggtgc      480

tgtgggtttc gtggctcagc tgaatgtgga gcgtggtgtg cagaggaggc ccccgcagac      540

catcaagagt gtgaggcagg catttgaccc tgtacagttc aacttcaaca agatccggcc      600

cggagaagtc ctcttccgtt tgcaccggga gcctgatctc cctgggactc tgctgcaaga      660

agacatcctg gtggtgatca acgtcagccc cctggagtgg ggccacgtgc tgctggtgcc      720

tgagcctgcc cgccagctcc cccagcgcct gctgccgggt gcactgaggg cagggattga      780

ggctgtgctg ctgagcttac acccgggctt ccgtgtcggc ttcaacagcc tgggaggctt      840

ggcctcggtg                                                             850


<210> 4624
<211> 5278
<212> DNA
<213> Homo sapiens

<400> 4624
ctgaggcgca gatcgctggc tctcgacgca ttactcttta cgccttacat ttctgtcttc       60

cttcctgggt cagtgattcc cggaccctgg aagagaagag ggtggctaat gattaaggct      120

ttccttaaag tttcccatgt ctcaatggac tcctgaatat aacgagctct acaccttaaa      180

agtggatatg aagagtgaga ttccttctga tgcaccaaag acacaggaga gtctgaaagg      240

gatccttttg catccagagc ccattggggc agccaaaagt tttcctgcag gagttgagat      300

gattaatagt aaagtgggga atgaattctc tcacctgtgt gatgattctc aaaagcaaga      360

gaaggaaatg aatggtaacc agcaagaaca agaaaaaagt ctcgttgtga ggaaaaaacg      420

caaaagccag caggctggcc cttcgtatgt gcagaattgt gttaaagaaa accagggaat      480

attaggactg aggcaacacc tagggacacc aagtgatgaa gataatgatt cctcttttag      540

tgattgtctt tcttctcctt catctagtct gcattttgga gattctgata ctgtgacttc      600

agatgaggat aaagaagtct ctgtaagaca ttcccagacc attttgaatg ctaaaagtag      660

aagccatagt gcacggtctc ataagtggcc tcggactgag acagaatctg tatcgggatt      720

gttaatgaaa agaccctgtt tacatggcag ttcgttacgg agacttccat gcagaaagag      780

atttgtaaaa aataattcct cacagaggac acagaaacaa aaagagagga tattaatgca      840

gaggaagaaa cgagaagtgt tagctcgaag aaaatatgcc ttgctaccta gttctagtag      900

ttccagtgag aatgacctca gcagtgaatc ctcttctagc tcatcaactg aaggagaaga      960

agatttgttt gtttctgcca gtgaaaacca ccaaaacaat ccagctgttc cctcaggaag     1020

tattgatgaa gatgttgtgg tgatagaagc ttcctccact ccccaggtta ctgccaatga     1080

agaaattaat gttacctcaa ctgacagtga agtggagatt gtaacagttg gagaaagcta     1140

tcggtctcgt tcaacccttg gacactccag atctcattgg agccagggtt ccagttctca     1200

tgcaagtcgg ccacaggagc cacggaaccg cagtaggatt tctactgtta tacagccctt     1260

gaggcagaat gcagcagaag ttgtggacct taccgttgat gaagatgaac ctactgtagt     1320

accaaccact tctgcaagaa tggaatcaca agctactagc gcttccatta acaattcaaa     1380

tccatctacc tctgagcagg cctctgatac tgcttcagct gtcaccagta gccaaccttc     1440

cacagtgtca gagacttcag ctactcttac aagcaatagt accactggca cttctatagg     1500

agatgactca aggagaacta catctagtgc tgtaacggaa actggccctc ctgcaatgcc     1560

aaggttacct tcctgctgtc cccagcactc accatgtgga gggtcgtcac agaaccacca     1620

tgcattagga catcctcata caagttgctt tcagcagcat ggtcaccatt ttcaacatca     1680

tcaccaccac caccatactc cccacccagc tgtcccagtt tctccttcct ttagtgatcc     1740

tgcttgccct gtggaaagac ctccacaagt acaagcacct tgtggagcaa atagtagttc     1800

tggtaccagc tatcatgaac agcaggcatt gccagtggac ctgagcaaca gtggtatcag     1860

aagtcatgga agtggcagtt ttcatggagc atctgcattt gacccctgct gccctgtttc     1920

ttcctcccga gctgcaatct ttggccatca ggccgctgct gctgccccaa gtcaaccttt     1980

atcatcaata gatggctatg gatcaagcat ggttgcgcag ccccagcccc agccccctcc     2040

acagccctct ctctcatcat gtcgacatta catgccaccc ccttatgcct ctttgacaag     2100

gccacttcat catcaagctt ctgcctgccc gcattctcat ggaaaccccc ctcctcagac     2160

tcagcctccg cctcaagtgg attatgttat tcctcatcct gtacatgctt tccattctca     2220

aatatcttct catgcaacat ctcatcctgt ggcaccccca ccaccaactc acttagccag     2280

tacagctgca ccaatccctc agcatcttcc tcctacacac cagccaattt cgcaccatat     2340

tccagccaca gcacctccag cacagagact gcatcctcat gaagtgatgc agaggatgga     2400

agttcaaagg aggaggatga tgcagcatcc aactggtctt tttgtgttct gtgtttccag     2460

gcgggcacat gaacgccccc caccccatcc acataggatg cacccaaact atggtcatgg     2520

gcatcatatt catgtgcctc agactatgtc ctcacatcct cgacaggctc cagagaggtc     2580

tgcctgggaa ctgggaattg aagctggagt gactgcagct acttatacac ctggtgcatt     2640

gcatcctcac ttggcccatt atcacgcacc tcctcgactt catcacttac aattaggagc     2700

tcttccttta atggttcctg atatggcagg ctatcctcac atccgttaca tttcatcagg     2760

attggatgga acatcattca gaggtccttt caggggcaat tttgaggaac tgattcattt     2820

ggaagaaaga ttaggcaatg tcaatcgtgg agcatcccag gggacaattg aaagatgtac     2880

atatccacat aaatacaaaa agaggaaact gcactgcaaa caagatgggg aagaagggac     2940

tgaggaagac acagaggaaa aatgtactat ctgtttgtct attttagagg aaggtgaaga     3000

tgtgagacgt cttccatgta tgcacctttt ccaccaagtg tgtgttgacc aatggttgat     3060

taccaataag aagtgcccca tatgcagagt ggacattgag gcccagctgc caagtgaaag     3120

ttgacaccat gtttcagaac tcttgccctc cctctcattc ccatccttcc tggtactgca     3180

gtcaaccaaa gatggcatga cttacctgcg cagatttgga agcattgaac ttagagtgct     3240

ggctctgcta tatggtacaa ctaatgctag acctacagtt tatgtataca gttgattttg     3300

atgtatttat aaaagctttt ttttctagat ttgacatttt tctgtatcat tttactgtat     3360

ttttgcatgg ttccttgtat tgcatttctt tgcacatatt atgggcttgt gaccctaaac     3420

ttgcaggcaa ggttagctgc tttagtaagt agaattttgt ggtctttttg ttttttacat     3480

agtaccaagc cttgataatt atgaattttt tatccattac taacctttaa tttaatcaat     3540

catgtacttt agtttaatgt ataaagatcc tctagaaaat gataatattg tgtattaaga     3600

cattccttaa ttaggacaaa atggctgctg tatatttact atatggagtt ctgagttaaa     3660

taccatcctt aatactggga acagaataca acccatataa atcagatgca ggtggtagtc     3720

acatcaccag agtgatcagt ataaattttc ttggtgtatc cttttccttt caacacagtg     3780

cagataagag ttgaatattg atatcataca tttagactgc tgttctgatt gcatttatct     3840

ttttcctaca tcatttagaa ttttatttcc ctgattcagt ttttgctgct gtgaaacagc     3900

tctgatgaac actaaatatt aatttcaatt agctagattg tacatacttg cagatttaac     3960

aaaattttag ggaaattgaa aaagacatgt agaatttgtt gtcttctgct aagcacgaaa     4020

agttaagata tctgcttaca ttgattttgt agacacatta agtcaagatt tggaatttaa     4080

gtcactggca ggtatctgtg cattcataga acttataaag gtcccaggat cacttttaag     4140

ggatttttat tagtttaaag gtaaataaag tcagctgaat ctacatgtct cttgttttat     4200

ttctctctaa acttgaaaac agtaaatctg cagatactgt gaggcacaaa ttatactgtc     4260

aacctactgt tgctatggtt atatactccc acttcataca ttaccaagag tcgatcactg     4320

atttaaaatt tttaatttct atagttaaga tttactgcat aatatagaat ataaagttaa     4380

gttaacatac taacatttct cctttggagg aagttttaat ctacttcagg atgcatatta     4440

ttatcaagat actttcatat acaggatagc ctaattttat ttgtttaaat atgcttaata     4500

tgccccagat tgcaaatgca tccagtcagt aatatcactg tctgtatgtg gaggacatgt     4560

tcccatggat catatgtgaa gatgtcaata agcttgcatt aagccacctg ctttgtaagt     4620

ggattgatta ataaataact tatatttcta ttgtctttgt gtttcataat tagtttttat     4680

aaaaacagtt tacattaaac atcttggaat tcaacaatag tgatctcact caaattgaca     4740

tttgcataat ttgacattta tattcattca gttatgacta cttgcccttt tcttcatatt     4800

agtaaatgtt acactgtagt agttgtcaat gttaacaggc ttcaacatag tatgtgtgca     4860

gatggacgat ggatttaaag agcatacctt atgattaaac cgaggttata gaaggtcagg     4920

ggagagtgaa ggagtcagtg acctatgtct gccatcttac tggggaaaag agcaagtagc     4980

ctgtcttcct ttaagtaagt agcctgtaat ggatgtacta ctttgccact ggaatacccc     5040

gggtctgtgc caagggactg aagaagtgta agatggggag aactgtatgt catggagtcc     5100

tcttgacgtt cccccagata caagtaaagc acaggtggat ttctctattt ttgaatacta     5160

catcagattt agatgcacga ctacctgttg acttgtttta taattgctac tgattttttt     5220

aatgtaggca aagctttgtt actttgaaat ttatttaata aaagtatttg tgacataa       5278


<210> 4625
<211> 3548
<212> DNA
<213> Homo sapiens

<400> 4625
ggcccaccgc cgcccaggca aggccgccct gccttgggcg cagcgctgcc atggctgggg       60

gccgtggggc ccccgggcgc ggccgggacg agcctccgga gagctacccg caacgacagg      120

accacgagct acaggccctg gaggccattt acggcgcgga cttccaagac ctgcggccgg      180

acgcttgcgg accggtcaaa gagccccctg aaatcaattt agttttgtac cctcaaggcc      240

taactggtga agaagtatat gtaaaagtgg atttgagggt taaatgccca cctacctatc      300

cagatgtagt tcctgaaata gagttaaaaa atgccaaagg tctatcaaat gaaagtgtca      360

atttgttaaa atctcgccta gaagaactgg ccaagaaaca ctgtggggag gtgatgatct      420

ttgaactggc ttaccacgtg cagtcatttc tcagcgagca taacaagccc cctcccaagt      480

cttttcatga agaaatgctg gaaaggcggg ctcaggagga gcagcagagg ctgttggagg      540

ccaagcggaa agaagagcag gagcaacgtg aaatcctgca tgagattcag agaaggaaag      600

aagagataaa agaagagaaa aaaaggaaag aaatggctaa gcaggaacgt ttggaaattg      660

ctagtttgtc aaaccaagat catacctcta agaaggaccc aggaggacac agaacggctg      720

ccattctaca tggaggctct cctgactttg taggaaatgg taaacatcgg gcaaactcct      780

caggaaggtc taggcgagaa cgtcagtatt ctgtatgtaa tagtgaagat tctcctggct      840

cttgtgaaat tctgtatttc aatatgggga gtcctgatca gctcatggtg cacaaaggga      900

aatgtattgg cagtgatgaa caacttggaa aattagtcta caatgctttg gaaacagcca      960

ctggtggctt tgtcttgttg tatgagtggg tccttcagtg gcagaaaaaa atgggtccat     1020

tccttaccag tcaagaaaaa gagaagattg ataagtgcaa aaagcagatt caaggaacag     1080

aaacagaatt caactcactg gtaaaattga gccatccaaa tgtagtacgc taccttgcaa     1140

tgaatctcaa agagcaagac gactccatcg tggtggacat tttagtggag cacattagtg     1200

gggtctctct tgctgcacac ctgagccact caggccccat ccctgtgcat cagcttcgca     1260

ggtacacagc tcagctcctg tcaggccttg attatctgca cagcaattct gtggtgcata     1320

aggtcctgag tgcatctaat gtcttggtgg atgcagaagg caccgtcaag attacggact     1380

atagcatttc taagcgcctc gcagacattt gcaaggagga tgtgtttgag caaacccgag     1440

ttcgttttag tgacaatgct ctgccttata aaacggggaa gaaaggagat gtttggcgtc     1500

ttggccttct gctgctgtcc ctcagccaag gacaggaatg tggagagtac cctgtgacca     1560

tccctagtga cttaccagct gactttcaag attttctaaa gaaatgtgtg tgcttggatg     1620

acaaggaaag atggagtccc cagcagttgt tgaaacacag ctttataaat ccccagccaa     1680

aaatgcctct agtggaacaa agtcctgaag attctgaagg acaagattat gttgagactg     1740

ttattcctag caaccggcta cccagtgctg ccttctttag tgagacacag agacagtttt     1800

cccgatactt cattgagttt gaagaattac aacttcttgg taaaggagct tttggagctg     1860

tcatcaaggt gtggtacaga gtcattccca gtccccttta gagctccttc tctgttccat     1920

ttccacaaag actcatggac tttactttta ttttgggagt ggggagggaa gtgaatatgg     1980

ctgttggata ctatgctcat cctcaccttc ctggagttaa aggttttatt taagttacgc     2040

tggacacagt tgagaattgt cccactcctc tttccttgct tcatgtggag cattaacatg     2100

aaacacacat ggttataaca gcacttcaag tggaatcaag acctccacag aaagaacatt     2160

tttgtgtgct ttggttcaga aagaacattg ttcttttttt ctcctgtttg ctgttagagt     2220

tgctgtagat aaaaaggttc taaggttaga agagagatgg acttcaaact gggagatggc     2280

cccagcaggt ctcgatggct tttattttcc agctattatt gggacaggaa agtagcgatg     2340

tattattaag gtacactgtt gttgggtctt cctttcttcg ttctagtcta tttgggtgac     2400

ttttattatt atctgcccct tgtagaaaga ggtttcagct gtttttatat aatagaagta     2460

tttctttgta aattaggaga cccagattat tgtattaagt ccatatacag tacatgtcat     2520

ctttcacata tgaaggtaac ccaccatcaa ctgagtatat tgtctgttaa ggattctgag     2580

agtatcatta ggaagcatta ctgttactgt agaaaaactt ttacactaaa aaaggaatta     2640

aattagtttt cctgtggtaa aagacagaca agcaagacag atgtcctgat cagaaagatc     2700

ataattatgt ctaagaggag gggatgattg aagcgtatac tgtcccttta acacaatatc     2760

attttgatca aatcctttaa cttcattcta ttttaaattc ttgaacgtag aatagtaaca     2820

aatttcatct ctttacaagt acttaataat gataggcaag ctcatataac aaaaacatct     2880

gagtaactta agcccccacg gtttccagta gtttctccct gtgagaatcc acagccctca     2940

cctcctacct ctgtgcttct gtgtcagagt agggcagcct gcccagtgat ctggcattca     3000

ttagcagttg gacccattac tgtttctgca ccttttcact tcagtaaatg aattcctagg     3060

ggtttccagt atagcaagct ttactcccaa cccagttcgt atatgatgtg tactgagaca     3120

ggagatcgaa aggcaatgcc aagatcccca cctcccgccc tacactgtcc tcttccctat     3180

taatgtggca gtaaaagaac acagggctat cattttttgg agcacctgcc atatttcaga     3240

ttgtgtgcca ggtgatttac aaaccttgtc tttaaatctc aggacattct tacgagatgg     3300

gtatgatcct cattccctag atgagggaac tgaagctcag agaaggttat gtcctttgcc     3360

tgagataagg gagataaaac cagcattcag acccacctct gttgtactac aaagtgtgtg     3420

ttcttgtcac tatttccata caaaaaaaga taatctgaaa ctcaattttg tagtacttcc     3480

ttcttattcc caggacttca cttagacttt tattagttta attgaaactt gtgagccaaa     3540

caagagaa                                                              3548


<210> 4626
<211> 541
<212> DNA
<213> Homo sapiens

<400> 4626
agcagatgct ggagctgctg gtgctggagc agtttctgag cgcgctgcca gccgacacgc       60

aggcctgggt gtgcagccgt cagccgctaa gctgggagga ggcggtggcc ctgctggaag      120

agttctgggc tttccttaaa gtttcccatg tctcaatgga ctcctgaata taacgagctc      180

tacaccttaa aagtggatat gaagagtgag attccttctg atgcaccaaa gacacaggag      240

agtctgaaag ggatcctttt gcatccagag cccattgggg cagccaaaag ttttcctgca      300

ggagttgaga tgattaatag taaagtgggg aatgaattct ctcacctgtg tgatgattct      360

caaaagcaag agaaggaaat gaatggtaac cagcaagaac aagaaaaaag tctcgttgtg      420

aggaaaaaac gcaaaagcca gcaggctggc ccttcgtatg tgcagaattg tgttaaagaa      480

aaccagggaa tattaggact gaggcaacac ctagggacac caagtgatga agataatgat      540

t                                                                      541


<210> 4627
<211> 2023
<212> DNA
<213> Homo sapiens

<400> 4627
tttttgtggg ccgggtgggt ttcctaatct ggtttcgtct gcctggttca tctgtgtgcg       60

atggctccgg actcggatcc cttccctgaa gggccgctct taaagctgct acccttagac      120

gctagagacc ggggcaccca gcgctgccgc ctgggcccgg ccgccctcca cgccctgggc      180

gcgcgcttgg gctcggcagt gaagatctcg ctacccgacg gcggctcctg cctctgcact      240

gcctggcctc ggcgggacgg agcggacggc tttgtgcagc tggacccgct gtgcgcgagc      300

cccggggcgg cggtcggggc gtcgagatcc cggaggagtc tcagcctgaa tcgcctcctc      360

ctagtgccct gtccgcccct gcggcgcgtc gccgtgtggc cggtgttgcg agagcgggca      420

ggcgcgcccg gtgcccggaa tacagccgcg gtgctggagg cggcacagga gctgctgaga      480

aaccgaccga tctccctggg ccacgtggtg gtcgctccgc caggcgctcc tggcctggtg      540

gctgccttgc acatcgtcgg cgggacgccc agtcccgatc ccgctgggct ggtcacccct      600

cgtacccgcg tcagccttgg cggggagcct ccgtcggaag cccagccgca gcccgaggtg      660

cccctgggag gtctttcgga ggcggccgac tcgctgcggg agctcctccg cctcccgctc      720

cgctacccgc gcgccctgac cgcgctgggc ttagcggtgc ctcgcggggt gctcctggcg      780

gggccccccg gagtgggcaa gacccagctg gtgcgggccg tggcgcgcga ggcgggcgcg      840

gagctgctgg cagtcagcgc cccggcgctg cagggttccc ggcctgggga gaccgaggag      900

aacgtgcggc gggtcttcca gcgcgcccgg gaactggcca gccgcggacc cagcctcctc      960

ttcctggacg agatggacgc cttgtgtccc cagcggggca gtcgagcacc cgagagccgc     1020

gtagtggccc aggtgttgac gctgctggac ggcgccagtg gggaccgcga ggtcgtggtt     1080

gtgggagcca ctaaccggcc ggacgctcta gacccagcgc tgcgtaggcc cgggagattt     1140

gaccgagagg tggtcattgg gactcccaca cttaaacaaa gaaaggaaat tctgcaagtg     1200

attacctcga agatgcccat ctccagtcat gttgatttgg gccttcttgc agaaatgaca     1260

gttggctatg ttggtgccga cctgacagca ctctgtaggg aggctgccat gcatgccctc     1320

cttcatagtg agaagaacca ggacaatcct gtgattgatg aaatagactt ccttgaagct     1380

tttaaaaata ttcagccctc atcgtttcga agcgtcattg gattaatgga tatcaagcct     1440

gttgactggg aggagattgg tggccttgaa gatgtaaaac tgaagttaaa acagagcatt     1500

gagtggcctc tgaaattccc ttgggaattt gttagaatgg gcctgacaca accaaaggga     1560

gttctcctct atgggccccc tggatgtgct aaaaccactc tggtgagggc cctggccaca     1620

agctgtcact gctctttcgt ttcagtgagt ggagctgatc tgttttcacc gtttgttgga     1680

gattcagaaa aagtgttgtc tcagatattt cgacaagcaa gagcaagcac tccagcaatt     1740

ttgtttttgg atgaaattga ttcaatcttg ggagctcgct cagccagcaa gacaggatgt     1800

gatgttcaag aacgagttct ttctgttctc ctgaatgaat tagatggtgt tggacttaag     1860

acaatagaga gaagaggaag taaatcaagt caacagggta aatacaagga gctgaaaaaa     1920

tgaagaggta tttattagcc agaatgcacc taaaatccag gccaacatta aatataatgc     1980

atatatgcta tagctttacc tatgctgaat tcatctcata gaa                       2023


<210> 4628
<211> 5115
<212> DNA
<213> Homo sapiens

<400> 4628
acttctaggg cattagacaa gttgcccaca gtcccaagtt agtagcccaa gttagtagcc       60

gagctaactc ctcgagtagg tctctgtgaa gcccagaggt catgcttgta actgctgtgc      120

tgaggccaac tttgtgcggt tgtttgccta tttactgggg actcccatat cccaaaagca      180

ttgtcgatgc ctctggtaag gtggcctcca ctgctgcctg gtcttcaact tctgggacat      240

gtgtatatct ccttacgatc cacaggtccc tgagtactga cggtcacagg ctgccgcgtc      300

tttcctgttg actcatgttt ggttcctcca gtgaaaattt tacttagaga aatgctgcct      360

ccaaagcact tgtctgccac caaacctaag aagtcctggg ccccaaatct gtatgagcta      420

gacagtgact tgactaagga gccggatgtc atcataggag aaggtccaac tgactctgag      480

ttttttcatc agaggtttcg gaacctaatc tatgtggaat ttgttgggcc tcggaagacc      540

ctgatcaaac tccgaaacct ctgcctcgat tggttgcagc cggagacccg caccaaggag      600

gagatcatcg agctcttggt ccttgagcag tacctgacca tcatccctga aaagctcaag      660

ccttgggtgc gagcaaaaaa gccggagaac tgtgagaagc tcgtcactct gctggagaat      720

tacaaggaga tgtaccaacc agaagacgac aacaacagtg acgtgaccag cgacgacgac      780

atgacccgga acagaagaga gtcctcacca cctcactcag tccattcttt cagtgaccgg      840

gactgggacc ggaggggcag aagcagagac atggagccac gagaccgctg gtcccacacc      900

aggaacccaa gaagcaggat gcctccgcgg gatctttccc ttcctgtggt ggcgaaaaca      960

agctttgaaa tggacagaga ggacgacagg gactccaggg cttatgagtc ccgatctcag     1020

gatgctgaat cataccaaaa tgtggtggac ctcgctgagg acaggaaacc tcacaacaca     1080

atccaggaca acatggaaaa ctacaggaag ctgctctccc tcgtgcagct tgctgaagac     1140

gatggccact cccacatgac gcagggccac tcatcaagat ccaagagaag tgcctaccca     1200

agcaccagtc gaggtctaaa aactatgcct gaagccaaaa aatcaaccca ccggcggggg     1260

atttgtgaag atgaatcttc ccacggagtg ataatggaaa aattcatcaa ggatgtgtca     1320

cgcagttcca aatcgggaag agcaagggag tcaagcgacc ggtcacagag attccccaga     1380

atgtcagatg ataactggaa ggacatttca ttgaacaaga gggagtcagt gatccagcag     1440

cgggtttatg aagggaatgc atttagggga ggctttaggt ttaattcaac ccttgtttcc     1500

agaaagagag ttcttgaaag aaagaggcgc tatcattttg acacagatgg gaagggctcg     1560

attcacgatc aaaaaggctg tcccaggaag aagccctttg aatgtggtag tgagatgaga     1620

aaagccatga gcgtgagcag cctgagcagc ctcagctccc cctcctttac cgagtcacag     1680

ccaattgatt ttggggcaat gccatatgta tgtgatgagt gtgggaggtc gttcagtgtc     1740

atctcagaat ttgttgagca ccagatcatg catactagag agaacctcta tgagtatggt     1800

gagtccttta tccacagtgt ggctgtcagt gaagttcaga aaagtcaggt tggagggaaa     1860

cgttttgaat gtaaggactg tggagagacc ttcaataaga gtgccgcctt ggctgaacat     1920

cggaagattc atgctagagg ttatcttgtg gaatgtaaga atcaggaatg tgaggaagcc     1980

ttcatgccta gccccacctt tagtgagctt cagaaaatat atggcaaaga caaattctac     2040

gagtgcaggg tgtgtaagga aaccttcctt catagttctg ccctgattga gcaccagaaa     2100

atccactttg gggatgacaa agataatgag cgtgaacatg aacgtgaacg tgaacgtgag     2160

cgcggggaaa cctttaggcc cagcccagcc cttaatgagt ttcagaaaat gtatggtaaa     2220

gagaaaatgt acgaatgtaa ggtgtgtggg gagactttcc ttcatagctc atccctgaaa     2280

gaacatcaga aaatccatac tagagggaac ccatttgaaa acaagggtaa agtgtgtgag     2340

gaaaccttta ttcctggtca gtcccttaaa aggcgtcaga aaacttacaa taaggagaag     2400

ctctgtgact ttacagatgg ccgggatgcc ttcatgcaaa gctcagagct cagtgagcat     2460

cagaaaattc attctcgaaa gaacctcttt gaaggcagag ggtatgagaa atctgtcatt     2520

catagtgggc cattcactga atctcagaag agtcatacta taacaagacc tcttgaaagt     2580

gatgaggacg aaaaggcgtt caccattagc tctaacccct atgaaaacca gaagattccc     2640

actaaggaaa atgtctatga ggcaaaatca tatgagaggt ctgttattca tagcttagcc     2700

tctgtggaag ctcagaaaag tcacagtgta gcagggccca gtaaaccaaa agtaatggca     2760

gagtctacca ttcagagctt cgatgctatc aaccatcaga gagttcgtgc tggagggaac     2820

acctctgaag gaagggaata cagtaggtct gttatccata gcttagtggc ttccaaacct     2880

ccaagaagtc acaatggaaa tgaattggtg gaatctaatg agaagggaga atcctccatt     2940

tatatctcag accttaatga taagcgacag aagattcctg ccagagagaa cccttgtgaa     3000

gggggcagta agaatcgcaa ctatgaagac tctgtcatac agagtgtatt ccgtgccaaa     3060

cctcagaaaa gtgttcctgg agagggatct ggtgagttta agaaggatgg cgaattctct     3120

gttcccagct caaatgtccg tgaataccag aaggctcgtg ctaaaaagaa atacattgag     3180

cataggagca atgagacctc tgtaattcac tctctgcctt ttggtgaaca aacatttcgc     3240

cctcgaggga tgctctatga atgtcaggag tgtggggagt gctttgctca tagctctgac     3300

ctcactgagc accagaagat tcatgatagg gagaagccct ctggaagcag aaactatgaa     3360

tggtctgtca ttcgcagctt ggcccctact gaccctcaaa caagttacgc ccaagagcag     3420

tatgctaaag agcaagcgcg gaacaaatgt aaggacttca gacaattttt tgctaccagc     3480

gaagacctca acacaaacca gaaaatctat gaccaagaga agtctcatgg cgaggagtct     3540

caaggcgaga atactgatgg ggaggagacc cacagcgagg agacccatgg tcaggagaca     3600

attgaagacc ctgtcattca aggctcagac atggaagacc ctcagaagga tgaccctgat     3660

gacaaaatct atgaatgtga ggactgtggc ctgggctttg tggatctcac agacctcaca     3720

gaccatcaga aagtccacag caggaagtgc ctggttgaca gtcgggagta cacacattct     3780

gtaattcaca cccattccat cagcgagtat cagagagatt acactggaga gcagctgtat     3840

gaatgtccaa agtgtgggga atcttttatt catagctcat tccttttcga gcatcagaga     3900

atccatgaac aagaccagtt gtattccatg aaggggtgtg atgatggttt tattgccctc     3960

ttgcccatga agccacggag gaatcgtgct gcagagagga atcctgctct tgctgggtcg     4020

gccattcgat gccttttgtg tggacaaggc ttcattcata gctctgccct taatgagcat     4080

atgagacttc atagggaaga tgatttactg gagcagagcc agatggctga ggaagctatc     4140

attccaggct tagccctcac tgagtttcag agaagtcaga ccgaagagag actctttgaa     4200

tgtgcagtct gtggagaatc tttcgtcaac ccagcagaac ttgcagatca cgtaactgtt     4260

cataagaatg agccctatga gtacgggtcc tcctatactc acacctcatt tcttactgag     4320

cccctcaaag gagctatacc attctatgaa tgcaaggatt gtggtaagtc ctttattcat     4380

agcacagtcc tcactaaaca taaggagctt catctggaag aagaagaaga agatgaagca     4440

gcagcagctg cagcagcagc agcccaggaa gttgaagcca atgtccatgt tccacaagta     4500

gttctgagga ttcagggctt aaacgtagag gctgctgagc cagaagtgga ggctgccgag     4560

ccagaagtgg aggctgctga gccagaagtg gaggctgctg agccaaacgg agaggctgaa     4620

gggccagatg gagaggctgc agagcccatt ggagaggctg gacagccaaa tggagaggcc     4680

gagcagccaa atggggatgc tgatgagcca gatggtgcag gtattgaaga cccagaagaa     4740

agagctgaag agccagaggg aaaagctgaa gagccagagg gagatgccga cgagcctgac     4800

ggtgtgggaa ttgaagaccc agaagaaggt gaagatcaag agattcaggt agaagaacca     4860

tactatgact gccatgaatg cacagaaacc ttcacttcca gcacagcatt cagtgaacac     4920

ctgaaaactc atgccagcat gatcatattt gagcctgcaa atgcctttgg ggagtgctca     4980

ggctacatcg aacgtgccag caccagcaca ggtggtgcca atcaagctga tgagaagtac     5040

ttcaaatgtg acgtctgtgg gcagctcttc aatgaccgcc tgtccctcgc cagacaccag     5100

aatacccaca ctggc                                                      5115


<210> 4629
<211> 577
<212> DNA
<213> Homo sapiens

<400> 4629
ctgcggagcc gggctcgggt cgccggagcc gcgccccacc ccgccagctc cagagccacg       60

tacgatggag tctccctctg tcgccaggct ggagtgcagt cttgtgatct cggctcactg      120

caacctccac ctcccgggtt cgagcgattc tcctgcctct gcctcccaag tagctgggac      180

tacaggcgcg caccaccact actggctaat ttttgtattt ttattaaaga cggggtttca      240

ccatgttggc aaggatggtc tccatctctt gacctcgtga tcctcccacc tcgacctcca      300

aaagtgctgg gattacaggc gtgagccacc gtgcctggcc tgaataatat catcttaaac      360

ttttgggact tgccttacca gtcatcagaa catttataca tttataagcc tattgtaatc      420

aagtcactgt tgtaagaata gacaagtgga ccagaataga gaatccagaa atagatcctg      480

ttagtggaaa agactaatgg ctgaaggata aatcaacatg gcaactatga ttccaccagt      540

gaagctgaaa tggcttgaac acttgaacag ctcctgg                               577


<210> 4630
<211> 4741
<212> DNA
<213> Homo sapiens

<400> 4630
gtttgggagg cgcgggagat gtccaccctg ggctggtggc gccgccgggc gccgggcgcc       60

atgagggtgc gctaggcggc tgttcgtgcc cgaggctgcg cagcactgag gtgagctttg      120

ccttcttgat cttccgtcct tcttggagac gactggcgag aggaagaggg actaggtcca      180

aacgctaggt ggctgggtcc agccggagac ccgcaccaag gaggagatca tcgagctctt      240

ggtccttgag cagtacctga ccatcatccc tgaaaagctc aagccttggg tgcgagcaaa      300

aaagccggag aactgtgaga agctcgtcac tctgctggag aattacaagg agatgtacca      360

accagaagac gacaacaaca gtgacgtgac cagcgacgac gacatgaccc ggaacagaag      420

agagtcctca ccacctcact cagtccattc tttcagtgac cgggactggg accggagggg      480

cagaagcaga gacatggagc cacgagaccg ctggtcccac accaggaacc caagaagcag      540

gatgcctccg cgggatcttt cccttcctgt ggtggcgaaa acaagctttg aaatggacag      600

agaggacgac agggactcca gggcttatga gtcccgatct caggatgctg aatcatacca      660

aaatgtggtg gacctcgctg aggacaggaa acctcacaac acaatccagg acaacatgga      720

aaactacagg aagctgctct ccctcgtgca gcttgctgaa gacgatggcc actcccacat      780

gacgcagggc cactcatcaa gatccaagag aagtgcctac ccaagcacca gtcgaggtct      840

aaaaactatg cctgaagcca aaaaatcaac ccaccggcgg gggatttgtg aagatgaatc      900

ttcccacgga gtgataatgg aaaaattcat caaggatgtg tcacgcagtt ccaaatcggg      960

aagagcaagg gagtcaagcg accggtcaca gagattcccc agaatgtcag atgataactg     1020

gaaggacatt tcattgaaca agagggagtc agtgatccag cagcgggttt atgaagggaa     1080

tgcatttagg ggaggcttta ggtttaattc aacccttgtt tccagaaaga gagttcttga     1140

aagaaagagg cgctatcatt ttgacacaga tgggaagggc tcgattcacg atcaaaaagg     1200

ctgtcccagg aagaagccct ttgaatgtgg tagtgagatg agaaaagcca tgagcgtgag     1260

cagcctgagc agcctcagct ccccctcctt taccgagtca cagccaattg attttggggc     1320

aatgccatat gtatgtgatg agtgtgggag gtcgttcagt gtcatctcag aatttgttga     1380

gcaccagatc atgcatacta gagagaacct ctatgagtat ggtgagtcct ttatccacag     1440

tgtggctgtc agtgaagttc agaaaagtca ggttggaggg aaacgttttg aatgtaagga     1500

ctgtggagag accttcaata agagtgccgc cttggctgaa catcggaaga ttcatgctag     1560

aggttatctt gtggaatgta agaatcagga atgtgaggaa gccttcatgc ctagccccac     1620

ctttagtgag cttcagaaaa tatatggcaa agacaaattc tacgagtgca gggtgtgtaa     1680

ggaaaccttc cttcatagtt ctgccctgat tgagcaccag aaaatccact ttggggatga     1740

caaagataat gagcgtgaac atgaacgtga acgtgaacgt gagcgcgggg aaacctttag     1800

gcccagccca gcccttaatg agtttcagaa aatgtatggt aaagagaaaa tgtacgaatg     1860

taaggtgtgt ggggagactt tccttcatag ctcatccctg aaagaacatc agaaaatcca     1920

tactagaggg aacccatttg aaaacaaggg taaagtgtgt gaggaaacct ttattcctgg     1980

tcagtccctt aaaaggcgtc agaaaactta caataaggag aagctctgtg actttacaga     2040

tggccgggat gccttcatgc aaagctcaga gctcagtgag catcagaaaa ttcattctcg     2100

aaagaacctc tttgaaggca gagggtatga gaaatctgtc attcatagtg ggccattcac     2160

tgaatctcag aagagtcata ctataacaag acctcttgaa agtgatgagg acgaaaaggc     2220

gttcaccatt agctctaacc cctatgaaaa ccagaagatt cccactaagg aaaatgtcta     2280

tgaggcaaaa tcatatgaga ggtctgttat tcatagctta gcctctgtgg aagctcagaa     2340

aagtcacagt gtagcagggc ccagtaaacc aaaagtaatg gcagagtcta ccattcagag     2400

cttcgatgct atcaaccatc agagagttcg tgctggaggg aacacctctg aaggaaggga     2460

atacagtagg tctgttatcc atagcttagt ggcttccaaa cctccaagaa gtcacaatgg     2520

aaatgaattg gtggaatcta atgagaaggg agaatcctcc atttatatct cagaccttaa     2580

tgataagcga cagaagattc ctgccagaga gaacccttgt gaagggggca gtaagaatcg     2640

caactatgaa gactctgtca tacagagtgt attccgtgcc aaacctcaga aaagtgttcc     2700

tggagaggga tctggtgagt ttaagaagga tggcgaattc tctgttccca gctcaaatgt     2760

ccgtgaatac cagaaggctc gtgctaaaaa gaaatacatt gagcatagga gcaatgagac     2820

ctctgtaatt cactctctgc cttttggtga acaaacattt cgccctcgag ggatgctcta     2880

tgaatgtcag gagtgtgggg agtgctttgc tcatagctct gacctcactg agcaccagaa     2940

gattcatgat agggagaagc cctctggaag cagaaactat gaatggtctg tcattcgcag     3000

cttggcccct actgaccctc aaacaagtta cgcccaagag cagtatgcta aagagcaagc     3060

gcggaacaaa tgtaaggact tcagacaatt ttttgctacc agcgaagacc tcaacacaaa     3120

ccagaaaatc tatgaccaag agaagtctca tggcgaggag tctcaaggcg agaatactga     3180

tggggaggag acccacagcg aggagaccca tggtcaggag acaattgaag accctgtcat     3240

tcaaggctca gacatggaag accctcagaa ggatgaccct gatgacaaaa tctatgaatg     3300

tgaggactgt ggcctgggct ttgtggatct cacagacctc acagaccatc agaaagtcca     3360

cagcaggaag tgcctggttg acagtcggga gtacacacat tctgtaattc acacccattc     3420

catcagcgag tatcagagag attacactgg agagcagctg tatgaatgtc caaagtgtgg     3480

ggaatctttt attcatagct cattcctttt cgagcatcag agaatccatg aacaagacca     3540

gttgtattcc atgaaggggt gtgatgatgg ttttattgcc ctcttgccca tgaagccacg     3600

gaggaatcgt gctgcagaga ggaatcctgc tcttgctggg tcggccattc gatgcctttt     3660

gtgtggacaa ggcttcattc atagctctgc ccttaatgag catatgagac ttcataggga     3720

agatgattta ctggagcaga gccagatggc tgaggaagct atcattccag gcttagccct     3780

cactgagttt cagagaagtc agaccgaaga gagactcttt gaatgtgcag tctgtggaga     3840

atctttcgtc aacccagcag aacttgcaga tcacgtaact gttcataaga atgagcccta     3900

tgagtacggg tcctcctata ctcacacctc atttcttact gagcccctca aaggagctat     3960

accattctat gaatgcaagg attgtggtaa gtcctttatt catagcacag tcctcactaa     4020

acataaggag cttcatctgg aagaagaaga agaagatgaa gcagcagcag ctgcagcagc     4080

agcagcccag gaagttgaag ccaatgtcca tgttccacaa gtagttctga ggattcaggg     4140

cttaaacgta gaggctgctg agccagaagt ggaggctgcc gagccagaag tggaggctgc     4200

tgagccagaa gtggaggctg ctgagccaaa cggagaggct gaagggccag atggagaggc     4260

tgcagagccc attggagagg ctggacagcc aaatggagag gccgagcagc caaatgggga     4320

tgctgatgag ccagatggtg caggtattga agacccagaa gaaagagctg aagagccaga     4380

gggaaaagct gaagagccag agggagatgc cgacgagcct gacggtgtgg gaattgaaga     4440

cccagaagaa ggtgaagatc aagagattca ggtagaagaa ccatactatg actgccatga     4500

atgcacagaa accttcactt ccagcacagc attcagtgaa cacctgaaaa ctcatgccag     4560

catgatcata tttgagcctg caaatgcctt tggggagtgc tcaggctaca tcgaacgtgc     4620

cagcaccagc acaggtggtg ccaatcaagc tgatgagaag tacttcaaat gtgacgtctg     4680

tgggcagctc ttcaatgacc gcctgtccct cgccagacac cagaataccc acactggctg     4740

a                                                                     4741


<210> 4631
<211> 647
<212> DNA
<213> Homo sapiens

<400> 4631
caaaaataaa ggacgcgacc gccgcagcct ctgcggagcc gggctcgggt cgccggagcc       60

gcgccccacc ccgccagctc cagagccacg tacgaaatgg ggtttcaccg tgttagccag      120

gatggtctca atctcctgac ctcgtgatcc gcccacctcg gcctcccaaa gtactgggat      180

tacaggacta atggctgaag gataaatcaa catggcaact atgattccac cagtgaagct      240

gaaatggctt gaacacttga acagctcctg gattacagag gacagtgaat ctattgctac      300

aagagaggga gttgctgttc tgtattctaa actggttagc aataaggaag tagtaccttt      360

gccccaacaa gttttatgcc tcaaaggacc acagttgcca gactttgaac gtgagtctct      420

ttcaagtgat gagcaggacc actatttgga tgcccttctt agcagccagc tagcattggc      480

aaagatggta tgttcagatt ccccatttgc cggggcactt agaaaacgac tgcttgtact      540

ccagcgtgtc ttttatgcac tttctaataa ataccatgac aaaggcaagg tgaagcagca      600

gcagcattct ccggagagca gttctggttc agcagatgtc cattctg                    647


<210> 4632
<211> 4789
<212> DNA
<213> Homo sapiens

<400> 4632
ggctaagcag gaacgtttgg aaattgctag tttgtcaaac caagatcata cctctaagaa       60

ggacccagga ggacacagaa cggctgccat tctacatgga ggctctcctg actttgtagg      120

aaatggtaaa catcgggcaa actcctcagg aaggtctagg cgagaacgtc agtattctgt      180

atgtaatagt gaagattctc ctggctcttg tgaaattctg tatttcaata tggggagtcc      240

tgatcagctc atggtgcaca aagggaaatg tattggcagt gatgaacaac ttggaaaatt      300

agtctacaat gctttggaaa cagccactgg tggctttgtc ttgttgtatg agtgggtcct      360

tcagtggcag aaaaaaatgg gtccattcct taccagtcaa gaaaaagaga agattgataa      420

gtgcaaaaag cagattcaag gaacagaaac agaattcaac tcactggtaa aattgagcca      480

tccaaatgta gtacgctacc ttgcaatgaa tctcaaagag caagacgact ccatcgtggt      540

ggacatttta gtggagcaca ttagtggggt ctctcttgct gcacacctga gccactcagg      600

ccccatccct gtgcatcagc ttcgcaggta cacagctcag ctcctgtcag gccttgatta      660

tctgcacagc aattctgtgg tgcataaggt cctgagtgca tctaatgtct tggtggatgc      720

agaaggcacc gtcaagatta cggactatag catttctaag cgcctcgcag acatttgcaa      780

ggaggatgtg tttgagcaaa cccgagttcg ttttagtgac aatgctctgc cttataaaac      840

ggggaagaaa ggagatgttt ggcgtcttgg ccttctgctg ctgtccctca gccaaggaca      900

ggaatgtgga gagtaccctg tgaccatccc tagtgactta ccagctgact ttcaagattt      960

tctaaagaaa tgtgtgtgct tggatgacaa ggaaagatgg agtccccagc agttgttgaa     1020

acacagcttt ataaatcccc agccaaaaat gcctctagtg gaacaaagtc ctgaagattc     1080

tgaaggacaa gattatgttg agactgttat tcctagcaac cggctaccca gtgctgcctt     1140

ctttagtgag acacagagac agttttcccg atacttcatt gagtttgaag aattacaact     1200

tcttggtaaa ggagcttttg gagctgtcat caaggtgcag aacaagttgg acggctgctg     1260

ctacgcagtg aagcgcatcc ccatcaaccc ggccagccgg cagttccgca ggatcaaggg     1320

cgaagtgaca ctgctgtcac ggctgcacca tgagaacatt gtgcgctact acaacgcctg     1380

gatcgagcgg cacgagcggc cggcgggacc ggggacgccg cccccggact ccgggcccct     1440

ggccaaggat gaccgagctg cacgcgggca gccggcgagc gacacagacg gcctggacag     1500

cgtagaggcc gccgcgccgc cacccatcct cagcagctcg gtggagtgga gcacttcggg     1560

cgagcgctcg gccagtgccc gtttccccgc caccggcccg ggctccagcg atgacgagga     1620

cgacgacgag gacgagcacg gtggcgtctt ctcccagtcc ttcctgcctg cttcagattc     1680

tgaaagtgat attatctttg acaatgaaga tgagaacagt aaaagtcaga atcagatgga     1740

gtactgtgag aagagcactt tacgagacac cattgaccag ggactgtatc gagacaccgt     1800

cagactctgg aggctttttc gagagattct ggatggatta gcttatatcc atgagaaagg     1860

aatgattcac cgggatttga agcctgtcaa catttttttg gattctgatg accatgtgaa     1920

aataggtgat tttggtttgg cgacagacca tctagccttt tctgctgaca gcaaacaaga     1980

cgatcagaca ggagacttga ttaagtcaga cccttcaggt cacttaactg ggatggttgg     2040

cactgctctc tatgtaagcc cagaggtcca aggaagcacc aaatctgcat acaaccagaa     2100

agtggatctc ttcagcctgg gaattatctt ctttgagatg tcctatcacc ccatggtcac     2160

ggcttcagaa aggatctttg ttctcaacca actcagagat cccacttcgc ctaagtttcc     2220

agaagacttt gacgatggag agcatgcaaa gcagaaatca gtcatctcct ggctgttgaa     2280

ccacgatcca gcaaaacggc ccacagccac agaactgctc aagagtgagc tgctgccccc     2340

accccagatg gaggagtcag agctgcatga agtgctgcac cacacgctga ccaacgtgga     2400

tgggaaggcc taccgcacca tgatggccca gatcttctcg cagcgcatct cccctgccat     2460

cgattacacc tatgacagcg acatactgaa gggcaacttc tcaatccgta cagccaagat     2520

gcagcagcat gtgtgtgaaa ccatcatccg catctttaaa agacatggag ctgttcagtt     2580

gtgtactcca ctactgcttc cccgaaacag acaaatatat gagcacaacg aagctgccct     2640

attcatggac cacagcggga tgctggtgat gcttcctttt gacctgcgga tcccttttgc     2700

aagatatgtg gcaagaaata atatattgaa tttaaaacga tactgcatag aacgtgtgtt     2760

caggccgcgc aagttagatc gatttcatcc caaagaactt ctggagtgtg catttgatat     2820

tgtcacttct accaccaaca gctttctgcc cactgctgaa attatctaca ctatctatga     2880

aatcatccaa gagtttccag cacttcagga aagaaattac agtatttatt tgaaccatac     2940

catgttattg aaagcaatac tcttacactg tgggatccca gaagataaac tcagtcaagt     3000

ctacattatt ctgtatgatg ctgtgacaga gaagctgacg aggagagaag tggaagctaa     3060

attttgtaat ctgtctttgt cttctaatag tctgtgtcga ctctacaagt ttattgaaca     3120

gaagggagat ttgcaagatc ttatgccaac aataaattca ttaataaaac agaaaacagg     3180

tattgcacag ttggtgaagt atggcttaaa agacctagag gaggttgttg gactgttgaa     3240

gaaactcggc atcaagttac aggtcttgat caatttgggc ttggtttaca aggtgcagca     3300

gcacaatgga atcatcttcc agtttgtggc tttcatcaaa cgaaggcaaa gggctgtacc     3360

tgaaatcctc gcagctggag gcagatatga cctgctgatt ccccagttta gagggccaca     3420

agctctgggg ccagttccca ctgccattgg ggtcagcata gctatagaca agatatctgc     3480

tgctgtcctc aacatggagg aatctgttac aataagctct tgtgacctcc tggttgtaag     3540

tgttggccag atgtctatgt ccagggccat caacctaacc cagaaactct ggacagcagg     3600

catcacagca gaaatcatgt acgactggtc acagtcccaa gaggaattac aagagtactg     3660

cagacatcat gaaatcacct atgtggccct tgtctcggat aaagaaggaa gccatgtcaa     3720

ggttaagtct ttcgagaagg aaaggcagac agagaagcgt gtgctggaga ctgaacttgt     3780

ggaccatgta ctgcagaaac tgaggactaa agtcactgat gaaaggaatg gcagagaagc     3840

ttccgataat cttgcagtgc aaaatctgaa ggggtcattt tctaatgctt caggtttgtt     3900

tgaaatccat ggagcaacag tggttcccat tgtgagtgtg ctagccccgg agaagctgtc     3960

agccagcact aggaggcgct atgaaactca ggtacaaact cgacttcaga cctcccttgc     4020

caacttacat cagaaaagca gtgaaattga aattctggct gtggatctac ccaaagaaac     4080

aatattacag tttttatcat tagagtggga tgctgatgaa caggcattta acacaactgt     4140

gaagcagctg ctgtcacgcc tgccaaagca aagatacctc aaattagtct gtgatgaaat     4200

ttataacatc aaagtagaaa aaaaggtgtc tgtgctattt ctgtacagct atagagatga     4260

ctactacaga atcttatttt aaccctaaag aactgtcgtt aacctcattc aaacagacag     4320

aggcttatac tggaataatg gaatgttgta cattcatcat aatttaaaat taaattctaa     4380

gaagaggctg ggtgcagtgg ctcacacctt taatcccagc actttgggaa gccaaggcag     4440

gaagactgct tgaaaccagg agtttgagac cagcctgagc aacaaagcaa gaccccatct     4500

ctataaaaac taaaaaaatt agttgggcat ggtggcacat gcctgtagtc ccagctactc     4560

cagaggctga gatggatcat ctgagcctca ggaggttgag gctgcagtga gctgtgactg     4620

cgccactgca ctccagtctg ggacaacaga gcaagaccct gtcttaaaaa aaaaaagaaa     4680

aaaaaaattt ttttctaaga agctgtccta caaagttgag ctttgttagt ttttcatgtg     4740

taatatatta taaatttatc ttttgggata taataaatgc tttcatata                 4789


<210> 4633
<211> 5052
<212> DNA
<213> Homo sapiens

<400> 4633
gtttgggagg cgcgggagat gtccaccctg ggctggtggc gccgccgggc gccgggcgcc       60

atgagggtgc gctaggcggc tgttcgtgcc cgaggctgcg cagcactgag gtgagctttg      120

ccttcttgat cttccgtcct tcttggagac gactggcgag aggaagaggg actaggtcca      180

aacgctaggt ggctgggtcc aggtccctga gtactgacgg tcacaggctg ccgcgtcttt      240

cctgttgact catgtttggt tcctccagtg aaaattttac ttagagaaat gctgcctcca      300

aagcacttgt ctgccaccaa acctaagaag tcctgggccc caaatctgta tgagctagac      360

agtgacttga ctaaggagcc ggatgtcatc ataggagaag gtccaactga ctctgagttt      420

tttcatcaga ggtttcggaa cctaatctat gtggaatttg ttgggcctcg gaagaccctg      480

atcaaactcc gaaacctctg cctcgattgg ttgcagccgg agacccgcac caaggaggag      540

atcatcgagc tcttggtcct tgagcagtac ctgaccatca tccctgaaaa gctcaagcct      600

tgggtgcgag caaaaaagcc ggagaactgt gagaagctcg tcactctgct ggagaattac      660

aaggagatgt accaaccaga agacgacaac aacagtgacg tgaccagcga cgacgacatg      720

acccggaaca gaagagagtc ctcaccacct cactcagtcc attctttcag tgaccgggac      780

tgggaccgga ggggcagaag cagagacatg gagccacgag accgctggtc ccacaccagg      840

aacccaagaa gcaggatgcc tccgcgggat ctttcccttc ctgtggtggc gaaaacaagc      900

tttgaaatgg acagagagga cgacagggac tccagggctt atgagtcccg atctcaggat      960

gctgaatcat accaaaatgt ggtggacctc gctgaggaca ggaaacctca caacacaatc     1020

caggacaaca tggaaaacta caggaagctg ctctccctcg tgcagcttgc tgaagacgat     1080

ggccactccc acatgacgca gggccactca tcaagatcca agagaagtgc ctacccaagc     1140

accagtcgag gtctaaaaac tatgcctgaa gccaaaaaat caacccaccg gcgggggatt     1200

tgtgaagatg aatcttccca cggagtgata atggaaaaat tcatcaagga tgtgtcacgc     1260

agttccaaat cgggaagagc aagggagtca agcgaccggt cacagagatt ccccagaatg     1320

tcagatgata actggaagga catttcattg aacaagaggg agtcagtgat ccagcagcgg     1380

gtttatgaag ggaatgcatt taggggaggc tttaggttta attcaaccct tgtttccaga     1440

aagagagttc ttgaaagaaa gaggcgctat cattttgaca cagatgggaa gggctcgatt     1500

cacgatcaaa aaggctgtcc caggaagaag ccctttgaat gtggtagtga gatgagaaaa     1560

gccatgagcg tgagcagcct gagcagcctc agctccccct cctttaccga gtcacagcca     1620

attgattttg gggcaatgcc atatgtatgt gatgagtgtg ggaggtcgtt cagtgtcatc     1680

tcagaatttg ttgagcacca gatcatgcat actagagaga acctctatga gtatggtgag     1740

tcctttatcc acagtgtggc tgtcagtgaa gttcagaaaa gtcaggttgg agggaaacgt     1800

tttgaatgta aggactgtgg agagaccttc aataagagtg ccgccttggc tgaacatcgg     1860

aagattcatg ctagaggtta tcttgtggaa tgtaagaatc aggaatgtga ggaagccttc     1920

atgcctagcc ccacctttag tgagcttcag aaaatatatg gcaaagacaa attctacgag     1980

tgcagggtgt gtaaggaaac cttccttcat agttctgccc tgattgagca ccagaaaatc     2040

cactttgggg atgacaaaga taatgagcgt gaacatgaac gtgaacgtga acgtgagcgc     2100

ggggaaacct ttaggcccag cccagccctt aatgagtttc agaaaatgta tggtaaagag     2160

aaaatgtacg aatgtaaggt gtgtggggag actttccttc atagctcatc cctgaaagaa     2220

catcagaaaa tccatactag agggaaccca tttgaaaaca agggtaaagt gtgtgaggaa     2280

acctttattc ctggtcagtc ccttaaaagg cgtcagaaaa cttacaataa ggagaagctc     2340

tgtgacttta cagatggccg ggatgccttc atgcaaagct cagagctcag tgagcatcag     2400

aaaattcatt ctcgaaagaa cctctttgaa ggcagagggt atgagaaatc tgtcattcat     2460

agtgggccat tcactgaatc tcagaagagt catactataa caagacctct tgaaagtgat     2520

gaggacgaaa aggcgttcac cattagctct aacccctatg aaaaccagaa gattcccact     2580

aaggaaaatg tctatgaggc aaaatcatat gagaggtctg ttattcatag cttagcctct     2640

gtggaagctc agaaaagtca cagtgtagca gggcccagta aaccaaaagt aatggcagag     2700

tctaccattc agagcttcga tgctatcaac catcagagag ttcgtgctgg agggaacacc     2760

tctgaaggaa gggaatacag taggtctgtt atccatagct tagtggcttc caaacctcca     2820

agaagtcaca atggaaatga attggtggaa tctaatgaga agggagaatc ctccatttat     2880

atctcagacc ttaatgataa gcgacagaag attcctgcca gagagaaccc ttgtgaaggg     2940

ggcagtaaga atcgcaacta tgaagactct gtcatacaga gtgtattccg tgccaaacct     3000

cagaaaagtg ttcctggaga gggatctggt gagtttaaga aggatggcga attctctgtt     3060

cccagctcaa atgtccgtga ataccagaag gctcgtgcta aaaagaaata cattgagcat     3120

aggagcaatg agacctctgt aattcactct ctgccttttg gtgaacaaac atttcgccct     3180

cgagggatgc tctatgaatg tcaggagtgt ggggagtgct ttgctcatag ctctgacctc     3240

actgagcacc agaagattca tgatagggag aagccctctg gaagcagaaa ctatgaatgg     3300

tctgtcattc gcagcttggc ccctactgac cctcaaacaa gttacgccca agagcagtat     3360

gctaaagagc aagcgcggaa caaatgtaag gacttcagac aattttttgc taccagcgaa     3420

gacctcaaca caaaccagaa aatctatgac caagagaagt ctcatggcga ggagtctcaa     3480

ggcgagaata ctgatgggga ggagacccac agcgaggaga cccatggtca ggagacaatt     3540

gaagaccctg tcattcaagg ctcagacatg gaagaccctc agaaggatga ccctgatgac     3600

aaaatctatg aatgtgagga ctgtggcctg ggctttgtgg atctcacaga cctcacagac     3660

catcagaaag tccacagcag gaagtgcctg gttgacagtc gggagtacac acattctgta     3720

attcacaccc attccatcag cgagtatcag agagattaca ctggagagca gctgtatgaa     3780

tgtccaaagt gtggggaatc ttttattcat agctcattcc ttttcgagca tcagagaatc     3840

catgaacaag accagttgta ttccatgaag gggtgtgatg atggttttat tgccctcttg     3900

cccatgaagc cacggaggaa tcgtgctgca gagaggaatc ctgctcttgc tgggtcggcc     3960

attcgatgcc ttttgtgtgg acaaggcttc attcatagct ctgcccttaa tgagcatatg     4020

agacttcata gggaagatga tttactggag cagagccaga tggctgagga agctatcatt     4080

ccaggcttag ccctcactga gtttcagaga agtcagaccg aagagagact ctttgaatgt     4140

gcagtctgtg gagaatcttt cgtcaaccca gcagaacttg cagatcacgt aactgttcat     4200

aagaatgagc cctatgagta cgggtcctcc tatactcaca cctcatttct tactgagccc     4260

ctcaaaggag ctataccatt ctatgaatgc aaggattgtg gtaagtcctt tattcatagc     4320

acagtcctca ctaaacataa ggagcttcat ctggaagaag aagaagaaga tgaagcagca     4380

gcagctgcag cagcagcagc ccaggaagtt gaagccaatg tccatgttcc acaagtagtt     4440

ctgaggattc agggcttaaa cgtagaggct gctgagccag aagtggaggc tgccgagcca     4500

gaagtggagg ctgctgagcc agaagtggag gctgctgagc caaacggaga ggctgaaggg     4560

ccagatggag aggctgcaga gcccattgga gaggctggac agccaaatgg agaggccgag     4620

cagccaaatg gggatgctga tgagccagat ggtgcaggta ttgaagaccc agaagaaaga     4680

gctgaagagc cagagggaaa agctgaagag ccagagggag atgccgacga gcctgacggt     4740

gtgggaattg aagacccaga agaaggtgaa gatcaagaga ttcaggtaga agaaccatac     4800

tatgactgcc atgaatgcac agaaaccttc acttccagca cagcattcag tgaacacctg     4860

aaaactcatg ccagcatgat catatttgag cctgcaaatg cctttgggga gtgctcaggc     4920

tacatcgaac gtgccagcac cagcacaggt ggtgccaatc aagctgatga gaagtacttc     4980

aaatgtgacg tctgtgggca gctcttcaat gaccgcctgt ccctcgccag acaccagaat     5040

acccacactg gc                                                         5052


<210> 4634
<211> 4536
<212> DNA
<213> Homo sapiens

<400> 4634
atgtctcaat ggactcctga atataacgag ctctacacct taaaagtgga tatgaagagt       60

gagattcctt ctgatgcacc aaagacacag gagagtctga aagggatcct tttgcatcca      120

gagcccattg gggcagccaa aagttttcct gcaggagttg agatgattaa tagtaaagtg      180

gggaatgaat tctctcacct gtgtgatgat tctcaaaagc aagagaagga aatgaatggt      240

aaccagcaag aacaagaaaa aagtctcgtt gtgaggaaaa aacgcaaaag ccagcaggct      300

ggcccttcgt atgtgcagaa ttgtgttaaa gaaaaccagg gaatattagg actgaggcaa      360

cacctaggga caccaagtga tgaagataat gattcctctt ttagtgattg tctttcttct      420

ccttcatcta gtctgcattt tggagattct gatactgtga cttcagatga ggataaagaa      480

gtctctgtaa gacattccca gaccattttg aatgctaaaa gtagaagcca tagtgcacgg      540

tctcataagt ggcctcggac tgagacagaa tctgtatcgg gattgttaat gaaaagaccc      600

tgtttacatg gcagttcgtt acggagactt ccatgcagaa agagatttgt aaaaaataat      660

tcctcacaga ggacacagaa acaaaaagag aggatattaa tgcagaggaa gaaacgagaa      720

gtgttagctc gaagaaaata tgccttgcta cctagttcta gtagttccag tgagaatgac      780

ctcagcagtg aatcctcttc tagctcatca actgaaggag aagaagattt gtttgtttct      840

gccagtgaaa accaccaaaa caatccagct gttccctcag gaagtattga tgaagatgtt      900

gtggtgatag aagcttcctc cactccccag gttactgcca atgaagaaat taatgttacc      960

tcaactgaca gtgaagtgga gattgtaaca gttggagaaa gctatcggtc tcgttcaacc     1020

cttggacact ccagatctca ttggagccag ggttccagtt ctcatgcaag tcggccacag     1080

gagccacgga accgcagtag gatttctact gttatacagc ccttgaggca gaatgcagca     1140

gaagttgtgg accttaccgt tgatgaagat gaacctactg tagtaccaac cacttctgca     1200

agaatggaat cacaagctac tagcgcttcc attaacaatt caaatccatc tacctctgag     1260

caggcctctg atactgcttc agctgtcacc agtagccaac cttccacagt gtcagagact     1320

tcagctactc ttacaagcaa tagtaccact ggcacttcta taggagatga ctcaaggaga     1380

actacatcta gtgctgtaac ggaaactggc cctcctgcaa tgccaaggtt accttcctgc     1440

tgtccccagc actcaccatg tggagggtcg tcacagaacc accatgcatt aggacatcct     1500

catacaagtt gctttcagca gcatggtcac cattttcaac atcatcacca ccaccaccat     1560

actccccacc cagctgtccc agtttctcct tcctttagtg atcctgcttg ccctgtggaa     1620

agacctccac aagtacaagc accttgtgga gcaaatagta gttctggtac cagctatcat     1680

gaacagcagg cattgccagt ggacctgagc aacagtggta tcagaagtca tggaagtggc     1740

agttttcatg gagcatctgc atttgacccc tgctgccctg tttcttcctc ccgagctgca     1800

atctttggcc atcaggccgc tgctgctgcc ccaagtcaac ctttatcatc aatagatggc     1860

tatggatcaa gcatggttgc gcagccccag ccccagcccc ctccacagcc ctctctctca     1920

tcatgtcgac attacatgcc acccccttat gcctctttga caaggccact tcatcatcaa     1980

gcttctgcct gcccgcattc tcatggaaac ccccctcctc agactcagcc tccgcctcaa     2040

gtggattatg ttattcctca tcctgtacat gctttccatt ctcaaatatc ttctcatgca     2100

acatctcatc ctgtggcacc cccaccacca actcacttag ccagtacagc tgcaccaatc     2160

cctcagcatc ttcctcctac acaccagcca atttcgcacc atattccagc cacagcacct     2220

ccagcacaga gactgcatcc tcatgaagtg atgcagagga tggaagttca aaggaggagg     2280

atgatgcagc atccaactgg tctttttgtg ttctgtgttt ccaggcgggc acatgaacgc     2340

cccccacccc atccacatag gatgcaccca aactatggtc atgggcatca tattcatgtg     2400

cctcagacta tgtcctcaca tcctcgacag gctccagaga ggtctgcctg ggaactggga     2460

attgaagctg gagtgactgc agctacttat acacctggtg cattgcatcc tcacttggcc     2520

cattatcacg cacctcctcg acttcatcac ttacaattag gagctcttcc tttaatggtt     2580

cctgatatgg caggctatcc tcacatccgt tacatttcat caggattgga tggaacatca     2640

ttcagaggtc ctttcagggg caattttgag gaactgattc atttggaaga aagattaggc     2700

aatgtcaatc gtggagcatc ccaggggaca attgaaagat gtacatatcc acataaatac     2760

aaaaaggtaa caactgattg gttctcacag aggaaactgc actgcaaaca agatggggaa     2820

gaagggactg aggaagacac agaggaaaaa tgtactatct gtttgtctat tttagaggaa     2880

ggtgaagatg tgagacgtct tccatgtatg caccttttcc accaagtgtg tgttgaccaa     2940

tggttgatta ccaataagaa gtgccccata tgcagagtgg acattgaggc ccagctgcca     3000

agtgaaagtt gacaccatgt ttcagaactc ttgccctccc tctcattccc atccttcctg     3060

gtactgcagt caaccaaaga tggcatgact tacctgcgca gatttggaag cattgaactt     3120

agagtgctgg ctctgctata tggtacaact aatgctagac ctacagttta tgtatacagt     3180

tgattttgat gtatttataa aagctttttt ttctagattt gacatttttc tgtatcattt     3240

tactgtattt ttgcatggtt ccttgtattg catttctttg cacatattat gggcttgtga     3300

ccctaaactt gcaggcaagg ttagctgctt tagtaagtag aattttgtgg tctttttgtt     3360

ttttacatag taccaagcct tgataattat gaatttttta tccattacta acctttaatt     3420

taatcaatca tgtactttag tttaatgtat aaagatcctc tagaaaatga taatattgtg     3480

tattaagaca ttccttaatt aggacaaaat ggctgctgta tatttactat atggagttct     3540

gagttaaata ccatccttaa tactgggaac agaatacaac ccatataaat cagatgcagg     3600

tggtagtcac atcaccagag tgatcagtat aaattttctt ggtgtatcct tttcctttca     3660

acacagtgca gataagagtt gaatattgat atcatacatt tagactgctg ttctgattgc     3720

atttatcttt ttcctacatc atttagaatt ttatttccct gattcagttt ttgctgctgt     3780

gaaacagctc tgatgaacac taaatattaa tttcaattag ctagattgta catacttgca     3840

gatttaacaa aattttaggg aaattgaaaa agacatgtag aatttgttgt cttctgctaa     3900

gcacgaaaag ttaagatatc tgcttacatt gattttgtag acacattaag tcaagatttg     3960

gaatttaagt cactggcagg tatctgtgca ttcatagaac ttataaaggt cccaggatca     4020

cttttaaggg atttttatta gtttaaaggt aaataaagtc agctgaatct acatgtctct     4080

tgttttattt ctctctaaac ttgaaaacag taaatctgca gatactgtga ggcacaaatt     4140

atactgtcaa cctactgttg ctatggttat atactcccac ttcatacatt accaagagtc     4200

gatcactgat ttaaaatttt taatttctat agttaagatt tactgcataa tatagaatat     4260

aaagttaagt taacatacta acatttctcc tttggaggaa gttttaatct acttcaggat     4320

gcatattatt atcaagatac tttcatatac aggatagcct aattttattt gtttaaatat     4380

gcttaatatg ccccagattg caaatgcatc cagtcagtaa tatcactgtc tgtatgtgga     4440

ggacatgttc ccatggatca tatgtgaaga tgtcaataag cttgcattaa gccacctgct     4500

ttgtaagtgg attgattaat aaataactta tatttc                               4536


<210> 4635
<211> 504
<212> DNA
<213> Homo sapiens

<400> 4635
gtgctggctg cgtatgcgtc acgggcgtca tgacctcgct gtggccccgg cagcggctgc       60

ggggaaagtc gcgaggtgca tccgcttcgg ctgcagctat ttactgagga cccactggat      120

gtcaagcatt gtgcatagtt ttcttcgatt gttgcaacat cccttgcgag agtttcactc      180

ctgttgccca ggctggagtg caatggcatg atctcagctc accgcaacct ccgcctcctg      240

agttcaagca gttctcctgc ctcagcctcc tgaatagctc ggattacagt ttctggagca      300

gcagagctga aggaacccaa acttggactg aagtgactct actaaggtca gctctatggc      360

tcttccacat gattcaaacg aaacttccta tttgctgcct cccaacaatg aggactgggg      420

caggcaaacc attcctgact ttgtttatgg gcagaaggat ctcatggcag aagggattca      480

gtggccaagg aatgcacctg gcat                                             504


<210> 4636
<211> 2026
<212> DNA
<213> Homo sapiens

<400> 4636
ggctccacgg ccacatccgc aaaaagggta ctggtgaacg tgacattttc acgaagccac       60

agcccatggt cactccctgc aaagctctga acttgcgcat tcccaggcca ggccgtggtt      120

gtctttccaa ggcggctcag cttgtgcttt gcttggagag agcggagggc agcagcacag      180

tgacagcgtc tgggacctca gaccagtttc cacagccact tatgaaagca gacggctcca      240

tgggctggag gaggtgggac gctctggaaa gaactcgggt gcgagtggga aagaaaatcg      300

agctgagcag ctggaagtcg aagtcgcgtg agtgaggacc agacactctc gatttaggca      360

aaggcggggt gcacttccca acaacacatc ctcctcactg gcgagaccag gcctgccctt      420

caagttcctc tcctgattta atccccttgg cgagggtttg gcatgaaatc aatggccagc      480

aagcttggta aacgaagccg cctacaccgc cctccccctc cctgcacggc cgcgccccgc      540

ctccgctcct gtctcaatct gggattgtcc tcctgtagcc ccaccatcca ccgtggggaa      600

cggtggagag actacaactc ccagtatgca ccgcgatgcg cgcctcaccc tgcatctccc      660

agcccgcagc cagctggcat cctagaccct ctgccctgcg accaacagcc gggagcggac      720

cagacaccag aactcccgga acggttgaag acggttccgc tccctgtccc gcctttcgca      780

gcccagcagt ttcgccctgc ggagaggagc cttgctgttt ccaaatctct cctgctgaag      840

agacattgga gctagggcgg ctagtttcac ctggtaattg tgacaccctg tctcctcgag      900

ctgcaggctt ttatgcttgt catgttcgaa gtttgatacc ttgcagatca acaaagggcc      960

ggtggcctct cactgcctcc gcggcagggt tgtcaagttt ttcaggttaa gtactgcacg     1020

actactcgct tctgaaactg atagacactg cctcagctcc gtgcagggca gacgcacaag     1080

agcagaatct ccgtgggaca tctctctgga gcatcaatat tactgcagta tttggaagaa     1140

acaaatttaa ataagttcta aggtgaagaa tggaacattt aagacaagtc tggaaagtca     1200

tctgccttta ataactgtcg tttgtcctta acgtcagact ttctccaaga ccaaaactct     1260

aagaacttat ttccattctt acaaatagta aaaatgataa atcatatcaa gtcaattgaa     1320

agtcctgcct gctgctttcc taaattgcaa tatggccttg gtatggtttt atttgtactt     1380

ttgtggggga ttcgtggatc tttagattaa aaaaaaaaaa ataggttttt gaacaatttt     1440

tgcaagtttg cagctgttag ttattgattt atttttccaa cccatctaat tcttctgtct     1500

ctctcctcag gctcaataat tccatgggtc tctaaggctg tgtttatttt ctttaaattt     1560

tgttgattta cttttatact ccatttgatt ttttctatct ctcacctttt ctcagactca     1620

gtcatcccac aggtctgtaa ggctctgttc attttcttta aacttctttt ttttttcctc     1680

tcctcagatt ggataaatta tattgctatg tctctgtttc tgaactatag aaaagctcaa     1740

aattattatt tttatttctc attttttata tggctatttt ttctctgctg atgtttcaca     1800

tctattcatt tatgagaata ttttcctttg ccctcatgag cgtgtttata atagctgcct     1860

tcaaattctt gtctgccgtt tacatcttgg acatcttgga gatggctact gcctgctttt     1920

tatcttgtgt atttattaca ttttcacgtg tcttcacgca tcccttgaat tggaaattgt     1980

gccctggaga ctgtatacaa gactggatta aaaagactgg attctg                    2026


<210> 4637
<211> 1790
<212> DNA
<213> Homo sapiens

<400> 4637
caggagtggc ctccgacgtc actgtggcgc gccgcttccg gtctgcagcc ttgtagtggg       60

gctggagcag agcctgccgc gaacccccgg agcccacgat ccctcgtgcc atccctcgaa      120

tccaccagca cgagcgtccc acccgcgcct gggaccatgg ccactgactc atgggccctg      180

gcggtggacg agcaggaagc tgcggctgag tcgaggacag agctgcccag tccttactca      240

acaagctgat cagaagcaac cttgttgata acacaaacca agtggaagtc ctgcagcggg      300

atccaaactc ccctctgtac tcggtgaagt cttttgaaga gcttcggctc ccacagaact      360

taattgccca atctcagtct ggtactggta aaacagctgc cttcgtgctg gccatgctta      420

gccaagtaga acctgcaaac aaataccccc agtgtctatg tctctcccca acgtatgagc      480

tcgccctcca aacaggaaaa gtgattgaac aaatgggcaa attttaccct gaactgaagc      540

tagcttatgc tgttcgaggc aataaattgg aaagaggcca gaagatcagt gagcagattg      600

tcattggcac ccctgggact gtgctggact ggtgctccaa gctcaagttc attgatccca      660

agaaaatcaa ggtgtttgtt ctggatgagg ctgatgtcat gatagccact cagggccacc      720

aagatcagag catccgcatc cagaggatgc tgcccaggaa ctgccagatg ctgcttttct      780

ccgccacctt tgaagactct gtgtggaagt ttgcccagaa agtggtccca gacccaaacg      840

ttatcaaact gaagcgtgag gaagagaccc tggacaccat caagcagtac tatgtcctgt      900

gcagcagcag agacgagaag ttccaggcct tgtgtaacct ctacggggcc atcaccattg      960

ctcaagccat gatcttctgc catactcgca aaacagctag ttggctggca gcagagctct     1020

caaaagaagg ccaccaggtg gctctgctga gtggggagat gatggtggaa cagagggctg     1080

cagtgattga gcgcttccga gagggcaaag agaaggtttt ggtgaccacc aacgtgtgtg     1140

cccgcggcat tgatgttgaa caagtgtctg tcgtcatcaa ctttgatctt cccgtggaca     1200

aggacgggaa tcctgacaat gagacctacc tgcaccggat cgggcgcacg ggccgctttg     1260

gcaagagggg cctggcagtg aacatggtgg acagcaagca cagcatgaac atcctgaaca     1320

gaatccagga gcattttaat aagaagatag aaagattgga cacagatgat ttggacgaga     1380

ttgagaaaat agccaactga gaagctccac cagccactga tgccagccct ggcactgccc     1440

ctgcacagga gacaagtgcg ttcagggcac aggccccgac atcaccccaa ggacaacggc     1500

acaagtagag agaaactacc tacctcactt caaattatgt ttggacttga caaaaatgta     1560

tgcaaatgat gggggatggt agaaaaaaat tatttacaca accttggaag attaggcatg     1620

aatacacaga gatttacctt ttggaagttt catcttttaa tttggccagt gtttccttca     1680

tgctaatcta gatgctgtgg ctgattactt gcccaggatc tcctgtggca gcctctgctt     1740

gttctctggc ttggagtgga tggggcagcc tccagctcct gtggaagtaa                1790


<210> 4638
<211> 2043
<212> DNA
<213> Homo sapiens

<400> 4638
ccgggatgtg caggccggga ggtagaggca ggctgatggg ggagggaacg agcagcctgt       60

gagacggggt gacggcggct accagcccgg gcgggcaccg ggactggaag agttgcctga      120

gcagccggct ggtccggcgg ccaggctagg gcgggggcga gcgcccagtt gagcctgctg      180

gggctggagg agcgagaagg gttctcttca catttcagag cgaaccagac ggacagtaag      240

gtttggagga agggggatcg ttggaagtag caggaagtgg agagaatctg gcaataggcg      300

agaaaccgaa agaatcagaa agaagtctat gtgagtagct gaaagcattg ggtgaccaga      360

aagaaggtcg ctgtaagtga aggaagagtg aggtgtggct ggatcaaagg gctaagagaa      420

gcgggtctgt gtaagtggat gtgagtgagg atcaaggaaa agccgtggaa gtggccgggg      480

gtcggggccg cagaagtgcc agacggggcc ggaaagcagc cgagcggagt tcaaatttga      540

gagcgtttgg aaattggaag acttggtggc gaacgagggt caggacctgc atcctgcctc      600

agagttatcg acgtatccgg aatgtgggat cagaggctgg tgaagttggc cctgttgcag      660

catctgcggg ccttctatgg tattaaggtg aagggtgtcc gtgggcagtg cgatcgcagg      720

agacatgaaa cagcagccac ggaaataggg ggtaaaatat ttggagtacc ttttaatgca      780

ctgccccatt ctgctgtacc agaatatgga cacattccaa gctttcttgt cgatgcttgc      840

acatctttag aagaacatat tcataccgaa gggctttttc ggaaatcagg atctgtgatt      900

cgcctaaaag cactaaagaa taaagtggat catggtgaag gttgcctatc ttctgcacct      960

ccttgtgata ttgcgggact tcttaagcag ttttttaggg aactgccaga gcccattctc     1020

ccagctgatt tgcatgaagc acttttgaaa gctcaacagt taggcacaga ggaaaagaat     1080

aaagctatac tgttgctctc ctgtcttctg gctgaccaca cagttcatgt attaagatac     1140

ttctttaact ttctcaggaa tgtttctctt agatccagtg agaataagat ggatagcagc     1200

aatcttgcag taatatttgc accaaatctt cttcagacaa gtgaaggaca tgaaaagatg     1260

tcttctaacg cagaaaagaa gggcgtgtac cagactttat cctggaaaag ataccagcca     1320

tgttgggtat tgatggtctc tgtgctactc catcactgga aggctttgaa gaaggtgaat     1380

atgaaactcc tggtgaatat aagagaaaga gaagacaacg tgtaggagat tttgttagtg     1440

gagcactaaa taaatttaaa cctaacagaa caccttctat tacacctcaa caagaaagaa     1500

ttgataatga aacaaccacc atcggttaaa tttgatccaa aaatattgca tctaccagca     1560

ttttcagtgg ataagttata atttctgaaa gaccaagatt ggaatgactt tttgtaacaa     1620

gtgtgctcgc agatcgactc cagtgagaag agctcgggga cctcctgagc caagtttaat     1680

ctcctttgct atttgtgcat ggtggctggt caccaggagg tggccaccag gcttctcctt     1740

tccccgctgt tctaattgct aatccagtat ttgcggatag ctccaaactg ggatatgacc     1800

accattgtat atgcagacca ttgactggaa catcatgatc tatctgcaca tgactgtaaa     1860

taacaactat tggatgtggc acagatggaa gctacataaa cactctatac aatatggcca     1920

attcaccggg ctccctgtta gtcttgtgag caattttaaa ctcttccacg attctttctc     1980

tgctttggag tgtttcaatt aattctccat tatattacaa tttacatttt tattaagcct     2040

tta                                                                   2043


<210> 4639
<211> 1760
<212> DNA
<213> Homo sapiens

<400> 4639
gcccccggct cccggaggtc gacattttgg tttccatagg caaagtccta acaccacaat       60

tgacatagtt aaaaagggga gacggtaacg tgtttggtag aggttacata tcttgctata      120

gttgtttatt ttagttgctg agtgatacac agccctcaaa gagtctgaca ttgtgcccat      180

ggttacactt gtccggggga gaccttgaat ttggtgtgga agaaataaca tcagtagttc      240

agaggacaga gctgcccagt ccttactcaa caagctgatc agaagcaacc ttgttgataa      300

cacaaaccaa gtggaagtcc tgcagcggga tccaaactcc cctctgtact cggtgaagtc      360

ttttgaagag cttcggctga aaccacagct tctccaagga gtctatgcca tgggtttcaa      420

tcgtccatcc aagatacaag agaacgcatt gccactgatg cttgctgagc ccccacagaa      480

cttaattgcc caatctcagt ctggtactgg taaaacagct gccttcgtgc tggccatgct      540

tagccaagta gaacctgcaa acaaataccc ccagtgtcta tgtctctccc caacgtatga      600

gctcgccctc caaacaggaa aagtgattga acaaatgggc aaattttacc ctgaactgaa      660

gctagcttat gctgttcgag gcaataaatt ggaaagaggc cagaagatca gtgagcagat      720

tgtcattggc acccctggga ctgtgctgga ctggtgctcc aagctcaagt tcattgatcc      780

caagaaaatc aaggtgtttg ttctggatga ggctgatgtc atgatagcca ctcagggcca      840

ccaagatcag agcatccgca tccagaggat gctgcccagg aactgccaga tgctgctttt      900

ctccgccacc tttgaagact ctgtgtggaa gtttgcccag aaagtggtcc cagacccaaa      960

cgttatcaaa ctgaagcgtg aggaagagac cctggacacc atcaagcagt actatgtcct     1020

gtgcagcagc agagacgaga agttccaggc cttgtgtaac ctctacgggg ccatcaccat     1080

tgctcaagcc atgatcttct gccatactcg caaaacagct agttggctgg cagcagagct     1140

ctcaaaagaa ggccaccagg tggctctgct gagtggggag atgatggtgg aacagagggc     1200

tgcagtgatt gagcgcttcc gagagggcaa agagaaggtt ttggtgacca ccaacgtgtg     1260

tgcccgcggc attgatgttg aacaagtgtc tgtcgtcatc aactttgatc ttcccgtgga     1320

caaggacggg aatcctgaca atgagaccta cctgcaccgg atcgggcgca cgggccgctt     1380

tggcaagagg ggcctggcag tgaacatggt ggacagcaag cacagcatga acatcctgaa     1440

cagaatccag gagcatttta ataagaagat agaaagattg gacacagatg atttggacga     1500

gattgagaaa atagccaact gagaagctcc accagccact gatgccagcc ctggcactgc     1560

ccctgcacag gagacaagtg cgttcagggc acaggccccg acatcacccc aaggacaacg     1620

gcacaagtag agagaaacta cctacctcac ttcaaattat gtttggactt gacaaaaatg     1680

tatgcaaatg atgggggatg gtagaaaaaa attatttaca caaccttgga agattaggca     1740

tgaatacaca gagatttacc                                                 1760


<210> 4640
<211> 3705
<212> DNA
<213> Homo sapiens

<400> 4640
gtggtctcgc gggcgggtga cgtcatcgag gcgagagagg cggagccgtg gacagtgggc       60

gggaggctgc caacggtttt gagcgtaggg ggaggcgtga gagggggatc tcaggggagg      120

aggtcaatcg cttgcccccc actttggcaa attggggact gaggactgga agggtggaga      180

gtaggcggaa ccaggtggtc gtcggggcag aggatctcgg gctaggcttg agggcggcgt      240

gcttcttagg gacgacttag ggcgtgactg agggttcaca aggtttcttt tggggtggtc      300

gggagggaga gattctaggg aacaaggaag ctcgctatgg ctttcttgcc aggaggggtc      360

gaagggaaag tacaagggag ctggagctga ccctgggtag aacgggtgaa gggatggggg      420

agcgtgaggt tccgccctct cttgagactg gaaccaattg agggactagt agggcagggg      480

gacagaaatt gggctcctag tggatttggg tccgtttccg ttgggacgtt ttgggtgtga      540

gaacttaaga gctcagttga ccggggatag cctgtgccgg agttgatctg cagcttccag      600

cactcgtagt cgggaagagg agcttcagca gcgctgttgt cccacagtag gtcttctgtc      660

cgcacccgct ctgcgctgca ccctcttaac gctgttccca ggagctgggg aaagggatgc      720

ttttgcccac tcccatggcc cctggaactg gtggaaacct ttcctctaac cagaaagcct      780

cgatatcctt aattcaccaa ggatccttgg cgtggagtct tcctcccttc tcccaagtct      840

ttctccgtga acttttcctc ctggactttg ctaaagcaga acctcccagc tctttgctgt      900

ctccggttgt ctcttccctg tattcatggc aacatcagct gacagcccca gttcacccct      960

cggggcggag gatctcctga gtgattcatc agaaccccct gggctcaacc aagtgtcgtc     1020

tgaagtgacc tcccagctct atgcttcttt gcgcctcagc cggcaggcgg aggccacggc     1080

ccgagcccag ctgtatttac cctccacctc cccgcctcat gaagggttag acggcttcgc     1140

ccaagaattg agtcgaagct tgtcagtcgg attggaaaag aacttgaaga aaaaggatgg     1200

ttctaagcat atctttgaga tggaaagtgt tcggggtcag ctccagacca tgctccaaac     1260

ctcacgtgat acagcctatc gggatcctct cattcctggc gctggctcag agagacggga     1320

agaggactcc tttgacagtg atagcacagc caccttgctc aacacccggc ccctgcaaga     1380

cttgtctcca tctagctcag cccaagccct ggaggagctg tttccccgct acaccagcct     1440

tcggccaggg cctccactca atcccccaga ttttcagggg ctgagagatg cattggattc     1500

agagcatacc cgccgcaagc attgtgagcg ccatattcag agcctgcaga cccgagtgtt     1560

agagctacag caacaattag ccgtggctgt ggctgccgac cgcaagaaag ataccatgat     1620

tgaacaactg gacaagaccc tggcccgtgt ggtggagggc tggaaccggc atgaggctga     1680

gcggacagag gttctcaggg gacttcaaga ggaacaccag gcagcagagc tcaccagaag     1740

caagcagcag gagacagtaa cccgcctgga acaaagcctt tctgaggcca tggaggccct     1800

gaatcgtgag caggaaagtg ccagactgca gcaacgggaa agagagacac tggaggagga     1860

aaggcaagct ctgactctga ggttggaggc agaacagcag cggtgctgtg tcctgcagga     1920

agagcgggat gcagctcggg ctgggcaact gagtgagcat cgagagttgg agactcttcg     1980

ggctgcccta gaagaagaac ggcagacctg ggcccagcaa gagcaccagc ttaaggaaca     2040

ctaccaggcg ctgcaggagg agagccaggc tcagctggaa agggagaagg agaagagcca     2100

gagggaagcc caggccgcct gggagaccca gcaccagttg gcattggtgc agtctgaggt     2160

gcggcggctg gaaggagagc tggatacagc tcggagagag agagatgccc tgcagctgga     2220

aatgagcttg gtgcaggccc ggtatgaaag ccagcggatc cagctggagt cggagctggc     2280

tgtgcagctg gagcagcggg tgacagagcg gctggcgcag gctcaggaga gcagcctacg     2340

gcaagcagcc tccctcaggg aacatcacag gaagcagctg caggacctga gtggacagca     2400

ccagcaggag ctggccagtc agctagctca gttcaaggtg gaaatggcag aacgagagga     2460

acggcaacag caggtggctg aggactacga gctcagactg gcccgggagc aagcgcgagt     2520

gtgcgaactg cagagtggga accagcagct ggaggagcag cgggtggagc tggtggaaag     2580

actgcaggcc atgctgcagg cccactggga tgaggccaac cagctgctca gcaccactct     2640

cccgccgccc aaccctccag ctcctcctgc tggaccctcc agccccgggc ctcaggagcc     2700

cgagaaggag gagaggaggg tctggactat gcctcccatg gccgtggccc tgaagcctgt     2760

attgcagcag agccgggaag caagggacga gctacctgga gcgcctcctg ttctttgcag     2820

ttcctcctca gatcttagcc tcctgttggg cccctctttt cagagccagc attctttcca     2880

gcccctggag cccaaaccag acctcacttc atccacagct ggggccttct ctgcacttgg     2940

ggccttccat cccgatcata gggcagaaag gccattccct gaggaagatc ctggacctga     3000

cggggagggc ctcctaaagc aagggctgcc gcctgctcag ctggagggcc tcaagaattt     3060

tttgcaccag ttgctggaga cagtgcccca gaacaatgag aacccttctg tcgacctgtt     3120

gccccctaag tctggtcctc tgactgtccc atcttgggag gaagcccctc aagtgccacg     3180

tattccaccg cctgtccaca aaaccaaagt tcccttagcc atggcatcca gtcttttccg     3240

ggtccctgag cctccctcct cccattcaca aggcagtggt cccagcagtg gttccccaga     3300

gagaggtgga gatgggctta cattcccaag gcagctgatg gaggtgtctc aactgttgcg     3360

actctaccag gctcggggct ggggggctct gcctgctgag gatctcctgc tctacctgaa     3420

gaggctggaa cacagcggga ctgatggccg aggggataat gtccccagaa ggaacacaga     3480

ctcccgcttg ggtgagatcc cccggaaaga gattccctcc caggctgtcc ctcgccgcct     3540

tgctacagcc cccaagactg aaaaacctcc cgcacggaag aaaagtgggc accctgcccc     3600

gagtagcatg aggagccggg ggggagtctg gagatgagcc cccctaccct ctctcctctt     3660

tgttctctca ttgttgttat tttaataaat gctcattagt ctgta                     3705


<210> 4641
<211> 1043
<212> DNA
<213> Homo sapiens

<400> 4641
gctgcaaagc ggggggccgc cgcctccctg ggcctgcctg ggcggccgcc tccgcgatgc       60

cgctgctcgt cgaggggcgg cgagtgcggc tgccgcagtc agccggggac ctcgtccgag      120

cccacccgcc tttggaggct ccatctccat tctgggttct gatgatgcca ctacttgtca      180

cattgtggtc ctgaggcaca caggtaatgg ggccacctgc ttgacacatt gtgacggaac      240

cgacaccaaa gctgaggtcc ccttgatcat gaactccata aaatcctttt ctgaccacgc      300

tcaatgtgga aggctggaag tacaccttgt tggaggcttc agtgacgaca ggcagttgtc      360

acaaaaactc actcatcaac ttcttagtga atttgacagg caagaagatg acattcactt      420

agtgacatta tgtgtgacag aattaaatga ccgggaagaa aacgaaaacc actttccagt      480

aatatatggc attgctgtca acattaagac tgcagagatt tacagagcat cctttcaaga      540

tcggggtccg gaggagcagc ttcgtgctgc gcgaacttta gcaggaggac caatgattag      600

catttatgat gcagagacag aacaacttcg tataggaccg tactcctgga caccatttcc      660

acatgtggat ttctggttgc accaagatga caagcaaata ctagagaatc tttccacttc      720

gcctctggct gagccacccc actttgttga acatattaga tctaccttga tgtttttaaa      780

aaaacaccca tctccagctc acacactgtt ttctggaaat aaagccctac tctacaaaaa      840

aaatgaagat ggcttgtggg aaaagatctc ttctccagga agttaaaaaa catgaattac      900

caaagaaagc accttcttgg cctgacagac cattggtggg gctggcacga atccagatct      960

ggatcctaca tctgttgggt cttaggcctc cttccctcct cagtgtcttt caaatgactt     1020

tcatcaaatg actttcaaaa taa                                             1043


<210> 4642
<211> 1641
<212> DNA
<213> Homo sapiens

<400> 4642
ggcgcgaggc ctgtgggccc agcggtgagg cagcagctgg gggcgggggg agggcggacc       60

tagcttccca gggcaggtga ttcgtcggcc ccggtggcgg cggcgcgtgc gacggtcacc      120

tcggtttggg gtccacctaa agtgggaagt ctgttttcaa aatgacatct actccatgcc      180

tgtcttgttt ccctaatgta ctttatggaa gttcttcaca ctactggagc attgacgtta      240

cttgttaagc agccttccac atcctagctc ttttccaagg aagatggaag agttgagtca      300

ggccctggct agtagctttt ctgtgtctca agatctgaac agcacagctg ccccacaccc      360

ccgcctatcc cagtacaagt ccaagtacag ttccttggag cagagtgagc gccgccggag      420

gttactggaa ctgcagaaat ccaagcggct ggattatgtg aaccatgcca gaagactggc      480

tgaagatgac tggacaggga tggagagtga ggaagaaaat aagaaagatg atgaagaaat      540

ggacattgac actgtcaaga agttaccaaa acactatgct aatcaattga tgctttctga      600

gtggttaatt gacgttcctt cagatttggg gcaggaatgg attgtggtcg tgtgccctgt      660

tggaaaaaga gcccttatcg tggcctccag gggttctacc agtgcctaca ccaagagtgg      720

ctactgtgtc aacaggtttt cttcacttct gccaggaggc aacaggcgaa actcaacagc      780

aaaagactac accattctag attgcattta caatgaggta aaccagacct actacgttct      840

ggatgtgatg tgctggcggg gacacccttt ttatgattgc cagactgatt tccgattcta      900

ctggatgcat tcaaagttac cagaagaaga aggactggga gagaaaacca agcttaatcc      960

ttttaaattt gtggggctaa agaacttccc ttgcactccc gaaagcctgt gtgatgtgct     1020

atctatggat ttcccttttg aggtagatgg acttctcttc taccacaaac agacccacta     1080

cagccccgga agcactccct tggtgggctg gctgcgcccc tacatggtgt cagatgtcct     1140

tggtgtagct gtgccggctg gcccgctgac caccaagcca gactatgctg ggcaccagct     1200

ccagcagatt atggagcaca agaagagcca gaaggaaggc atgaaggaga aactcacaca     1260

caaggcctct gagaatgggc actatgaatt ggagcacctg tctactccca agttgaaggg     1320

ttcttcccat agcccagacc accctggatg cctcatggag aattaaagag agaagcctcc     1380

ttaaggagcc acaggatggt acctggcccc aaaaggaatc ctggagagga ggacagtgac     1440

aacaggtgac ttcattcttt agagtgaact ttccaaaccc agtccagctg gaaacagctt     1500

atctataatc tgaaatgctg gctcaaacag ttatggggag gttcccagat tgcgtagcat     1560

tcagattgat ttgagcagct cctactgtga taagtgtatc ccagatccac aatgtaaata     1620

tatgtgattt gtaagaaaga a                                               1641


<210> 4643
<211> 1792
<212> DNA
<213> Homo sapiens

<400> 4643
ctcattttct cttgccgcca ccatgtaaga agcgcctttc gcctccctcc atgattctga       60

ggcctcccca gccacatggt acttgtatgc ctagacagcg ggcacagggc ttgctggaca      120

cagaaggcaa ggactcagag aatatccacc agatgaaaga atgactgcat gacctgatcc      180

tgcctgaaga tggtgccact ggtggctgtg gtatcagggc cccgtgccca gctctttgcc      240

tgcctgctca ggctgggcac tcagcaggtc ggcccccttc agctgcacac cggggccagc      300

catgcggcca ggaaccatta tgaggtgctg gtgctgggtg ggggcagtgg cggaatcacc      360

atggctgccc gcatgaagag gaaagtgggt gcagagaatg tggccattgt tgagcccagt      420

gagagacatt tctaccagcc aatctggaca ctggtgggtg ctggtgccaa acaattgtcc      480

tcatctggtc gtcccacggc aagtgtgatt ccatctggtg tagaatggat caaagctaga      540

gtgactgagt tgaacccaga caagaactgc attcacacag atgacgacga gaagatctcc      600

taccgatatc ttattattgc tctcggaatc cagctggact atgagaagat taaaggccta      660

cctgaaggtt tcgctcatcc caaaataggg tcgaattatt cagttaagac tgtagagaag      720

acatggaaag ctctgcagga cttcaaagag ggcaatgcca tcttcacctt cccaaatact      780

ccagtgaagt gtgctggagc ccctcagaag atcatgtact tatcagaagc ctacttcagg      840

aagacaggga agcgatccaa ggccaatatc attttcaaca cttctcttgg agccattttc      900

ggggttaaga agtatgcaga tgccctgcag gagatcatcc aggagcggaa cctcactgtt      960

aactacaaga aaaacctcat tgaagtccga gccgataaac aagaggctgt atttgagaac     1020

ctggacaaac caggagagac ccaagtgatt tcatatgaaa tgcttcatgt cacacctcca     1080

atgagcccac cagatgtcct caagaccagt cctgtggctg atgctgctgg ttgggtggat     1140

gtggataaag aaactctgca acacaggagg tacccaaatg tgtttgggat tggggactgc     1200

accaaccttc ctacgtcaaa gaccgctgct gcagtagctg cccagtcagg aatacttgat     1260

aggacaattt ctgtaattat gaagaatcaa acaccaacaa agaagtatga tggctacaca     1320

tcatgtccac tggtgaccgg ctacaaccgt gtgattcttg ctgagtttga ctacaaagca     1380

gagccgctag aaaccttccc ctttgatcaa agcaaagagc gcctttccat gtatctcatg     1440

aaagctgacc tgatgccttt cctgtattgg aatatgatgc taaggggtta ctggggagga     1500

ccagcgtttc tgcgcaagtt gtttcatcta ggtatgagtt aaggatggct cagcacttgc     1560

tcatcttgga tggcttctgg gccaaaactg cagtcactga atgaccaaga gcagcacgaa     1620

ggacttggaa cctatccttg taaagagttc cttgatgggt aatggtgacc aaatgcctcc     1680

cttttcagta cctttgaaca gcaaccatgt gggctactca tgatgggctt gattctttgg     1740

gaataataaa atgaaataat acttttattt tctgaataaa agtttgtcac tg             1792


<210> 4644
<211> 1681
<212> DNA
<213> Homo sapiens

<400> 4644
atgctcagcc gcgatggctg gggctgccgg gcgcgtccaa gatcgcgccc tgcggcggtt       60

tcccatcacc ctgcctgtgg gcgacgtgag tatctgcgag ggtagaagcc agaccctttc      120

ctcccacgtt taggtgcctt cctcgcccct actcctgggt agaggaataa caatatttct      180

cgaggcttcg gcccaaggtc ttagccttgt gatctagaat ccgccatctg tgaggtgctg      240

ttgtcaagac caatgccaat gcagagaaga cagatgaaga agagaaagag gacagagctg      300

cccagtcctt actcaacaag ctgatcagaa gcaaccttgt tgataacaca aaccaagtgg      360

aagtcctgca gcgggatcca aactcccctc tgtactcggt gaagtctttt gaagagcttc      420

ggctgaaacc acagcttctc caaggagtct atgccatggg tttcaatcgt ccatccaaga      480

tacaagagaa cgcattgcca ctgatgcttg ctgagccccc acagaactta attgcccaat      540

ctcagtctgg tactggtaaa acagctgcct tcgtgctggc catgcttagc caagtagaac      600

ctgcaaacaa atacccccag tgtctatgtc tctccccaac gtatgagctc gccctccaaa      660

caggaaaagt gattgaacaa atgggcaaat tttaccctga actgaagcta gcttatgctg      720

ttcgaggcaa taaattggaa agaggccaga agatcagtga gcagattgtc attggcaccc      780

ctgggactgt gctggactgg tgctccaagc tcaagttcat tgatcccaag aaaatcaagg      840

tgtttgttct ggatgaggct gatgtcatga tagccactca gggccaccaa gatcagagca      900

tccgcatcca gaggatgctg cccaggaact gccagatgct gcttttctcc gccacctttg      960

aagactctgt gtggaagttt gcccagaaag tggtcccaga cccaaacgtt atcaaactga     1020

agcgtgagga agagaccctg gacaccatca agcagtacta tgtcctgtgc agcagcagag     1080

acgagaagtt ccaggccttg tgtaacctct acggggccat caccattgct caagccatga     1140

tcttctgcca tactcgcaaa acagctagtt ggctggcagc agagctctca aaagaaggcc     1200

accaggtggc tctgctgagt ggggagatga tggtggaaca gagggctgca gtgattgagc     1260

gcttccgaga gggcaaagag aaggttttgg tgaccaccaa cgtgtgtgcc cgcggcattg     1320

atgttgaaca agtgtctgtc gtcatcaact ttgatcttcc cgtggacaag gacgggaatc     1380

ctgacaatga gacctacctg caccggatcg ggcgcacggg ccgctttggc aagaggggcc     1440

tggcagtgaa catggtggac agcaagcaca gcatgaacat cctgaacaga atccaggagc     1500

attttaataa gaagatagaa agattggaca cagatgattt ggacgagatt gagaaaatag     1560

ccaactgaga agctccacca gccactgatg ccagccctgg cactgcccct gcacaggaga     1620

caagtgcgtt cagggcacag gccccgacat caccccaagg acaacggcac aagtagagag     1680

a                                                                     1681


<210> 4645
<211> 796
<212> DNA
<213> Homo sapiens

<400> 4645
cgcagatcat gggtggcggg tatgatctca acctcttcgc cagccctcct gacagcaact       60

tcgtgtgctc cgtctgccat ggggttctca agaggccagc aaggttgcca tgcagccaca      120

tcttctgcaa aaagtgcatc ctccggtggc tagccagaca aaagacctgt ccgtgctgta      180

ggaaagaggt gaaaaggaaa aaggttgtcc acatgaataa actccggaaa accattggcc      240

gcctggaagt caagtgcaag aacgccgacg ctggctgcat agtgacatgc cccctggccc      300

atcgcaaggg gcaccaggac tcatgcccct ttgagctaac ggcctgcccc aacgagggct      360

gcacctcgca ggtgccgcgt gggaccctgg cagagcaccg gcagcattgc cagcaagggt      420

cccagcagcg ctgccccctg ggctgcgggg ccaccctgga cccggccgag cgtgctcgcc      480

acaactgcta ccgggagctg cacaacgcct ggagcgtgcg ccaggagcgc cgtcggcccc      540

tgctgctgtc cctcctgcgg cgtgtgcgct ggctggacca agccaccagt gtcgttcgta      600

gagagctggc ggagctcagc aacttcctgg aggaagacac cgctctgctg gagggtgccc      660

cacaggagga ggccgaggct gccccagaag gcaacgttgg ggctgaggtg gtgggggagc      720

ccagggccaa cataccttgt aaataggtaa ataaaagcag acccccggcc tgcctgcctc      780

tgtgcctgcg gccctc                                                      796


<210> 4646
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 4646
gagagactac aactcccagt atgcaccgcg atgcgcgcct caccctgcat ctcccagccc       60

gcagccagct ggcatcctag accctctgcc ctgcgaccaa cagccgggag cggaccagac      120

accagaactc ccggaacggt tgaagacggt tccgctccct gtcccgcctt tcgcagccca      180

gcagtttcgc cctgcggaga ggagccttgc tgtttccaaa tctctcctgc tgaagagaca      240

ttggagctag ggcggctagt ttcacctggc tgtcacaaat cctctgcacc ccaggagcgc      300

cgcttggacc cccgggctcg ctgcgtggtc catatctagg tcgggcctct cacggagact      360

ttcccaccag tgtaataaag aggagaaaac gtcacagcgg aagggcctga ccctgctgca      420

tccactaagg aaacagctac ggggatggga ccctgggagc tgctgtggag cctcatccac      480

cgcttctctg accccaccca ggctgcttcc caggcctcag ggtcttagtg tggacctccg      540

ggccgtgatt aatgcaggtc agcaggacca gagcgcccct tggtccctcc caacacatga      600

gggtagtttg tgtggtgagg tcagggatag tgtctgcgct tctaccctga atagggctcc      660

cttggaaaat actttaatat ctctttttaa ataccccctt ggaccacttt taatagtttt      720

ctgatagaac taaacagtga tcattctctt aattcatgtt tccattaagt ttttcaggtt      780

aagtactgca cgactactcg cttctgaaac tgatagacac tgcctcagct ccgtgcaggg      840

cagacgcaca agagcagaat ctccgtggga catctctctg gagcatcaat attactgcag      900

tatttggaag aaacaaattt aaataagttc taaggtgaag aatggaacat ttaagacaag      960

tctggaaagt catctgcctt taataactgt cgtttgtcct taacgtcaga ctttctccaa     1020

gaccaaaact ctaagaactt atttccattc ttacaaatag taaaaatgat aaatcatatc     1080

aagtcaattg aaagtcctgc ctgctgcttt cctaaa                               1116


<210> 4647
<211> 4134
<212> DNA
<213> Homo sapiens

<400> 4647
ggcttgctcg cgcgtgcgca ccagaagcca gcagtggggt tgcacacgcg cctcttcacg       60

aggtggaaac aagatggagg attcggcctc ggcctcgctg tcttctgcag ccgctactgg      120

aacctccacc tcgactccag cggccccgac agcacggaag cagctggata aagaacaggt      180

tagaaaggca gtggacgctc tcttgacgca ttgcaagtcc aggaaaaaca attatgggtt      240

gcttttgaat gagaatgaaa gtttattttt aatggtggta ttatggaaaa ttccaagtaa      300

agaactgagg gtcagattga ccttgcctca tagtattcga tcagattcag aagatatctg      360

tttatttacg aaggatgaac ccaattcaac tcctgaaaag acagaacagt tttatagaaa      420

gcttttaaac aagcatggaa ttaaaaccgt ttctcagatt atctccctcc aaactctaaa      480

gaaggaatat aaatcctatg aagccaagct ccgccttctg agcagttttg atttcttcct      540

tactgatgcc agaattaggc ggctcttacc ctcactcatt gggagacatt tctatcaaag      600

aaagaaagtt ccagtatctg taaaccttct gtccaagaat ttatcaagag agatcaatga      660

ctgtataggt ggaacagtct taaacatttc taaaagtggt tcttgcagtg ctatacgtat      720

tggtcacgtt ggaatgcaaa ttgagcacat cattgaaaac attgttgctg tcaccaaagg      780

actttcagaa aaattgccag agaagtggga gagcgtgaaa ctcctgtttg tgaaaactga      840

gaaatcggct gcacttccca tcttttcctc gtttgtcagc aattgggatg aagccaccaa      900

aagatctttg cttaataaga agaaaaaaga ggcaaggaga aaacgaagag aaagaaattt      960

tgaaaaacaa aaggagagga agaagaagag gcagcaggct aggaagactg catcagttct     1020

tagtaaagat gatgtggcac ctgaaagtgg tgatactaca gtgaagaaac ctgaatcaaa     1080

gaaggaacag accccagagc atgggaagaa aaaacgtggc agaggaaaag cccaagttaa     1140

agcaacaaat gaatccgaag acgaaatccc acagctggta ccaataggaa agaagactcc     1200

agctaatgaa aaagtagaga ttcaaaaaca tgccacagga aagaagtctc cagcaaagag     1260

tcctaatccc agcacacctc gtgggaagaa aagaaaggct ttgccagcat ctgagacccc     1320

aaaagctgca gagtctgaga ccccagggaa aagcccagag aagaagccaa aaatcaaaga     1380

agaggcagtg aaggaaaaaa gtccttcgct ggggaaaaaa gatgcgagac agactccaaa     1440

aaagccagag gccaagtttt tcaccactcc tagtaaatct gtgagaaaag cttcccacac     1500

ccccaaaaaa tggcccaaaa aacccaaagt accccagtcg acctaaagtc agtgattcaa     1560

ctggaaggaa acctcaatgc tgcctccaga gctttttgga aatactcaga tcctggccgc     1620

ctttgtaacc ttctctaaac gtcaggcctg gacttaaaag attttttaaa acctccataa     1680

gtagtccagg ggcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcaggc     1740

ggatcacaag gtcaacgaga tcgagaccat cctggccaac atggtgaaac cctgtctgta     1800

ccaaaaatac aaaaattaat tgggcatggt ggtggacacc tgtaatccca gctactaggg     1860

aggctgaggc aggagaattg cttgaacctg ggaggcggag gttgcagtga gccactgcac     1920

tccagcctga tgacagagca agactcagtc tcaaaaataa ataaaaataa taaaacctcc     1980

ataagtaatc ctgacatatg ttcctgggta taatctgttt ctaaattgtc cttctgtgta     2040

tttgctaatg taatagaggg aaaaatagag tgcttctctg tggttgttca gcactttagg     2100

tagccaaggt gagaggattg cttgaggcca ggagtttgag actagcctgg gcaacttggt     2160

aaaaccccat ctctacaaaa gaaaaaaaaa aattagtgtg gcatggtggc atgcatctgt     2220

gctcccagct cctcacgagg ctgaggtgga aggatcaagt gagcgcaaga ggttgaggct     2280

ccagtgagcc acgatcaccc cactgtgctg tagcctgggt gacagtgtga gattctgtct     2340

cagaaaaaac aaagtataac attgctttgc ttctgagtat actgttggct ttccaaatca     2400

gtgggtctga cttgaggtct gtgatgtgac ccttttcctc acctgctcaa ccattattca     2460

catggactcc atcatattca tttgtagtca ttcccagagt ggcccagtga gggtctcgct     2520

gtatgagagt cggctacgga atttaggaga aacagaagtt tcttggcttt catgctgagc     2580

ttgttggtct aagcttatga gtcactggat tagcatccat atgggaaggg aaattaacat     2640

ggagtcattt atacagggac taaattgaat cctacctacc ggaggcaaga acatgattta     2700

tcttccataa gccttatcct cttcctcctt attcctcagt ccatatggat ttgcttatgt     2760

atgacaactc caaggaatct tggaagagta gattgctaac gtttccacaa ttgtcaagta     2820

tattctgagg cagtaaacac ctttttaggt acgtggcctt tcactggttg tgaattggta     2880

tgcatccgta gtagtaagtt cacagattca ctgcagtgca ggaatgttct tgcatgccaa     2940

agactcaact gctttcaaag ataatgtggg tgctagatgc agtggcttac atctgtaacc     3000

ctgttagggt gaccagaccc aacaccaggt cgtgggggtg acaaagtcca gtggagtcaa     3060

aggattgaga aaaagacagt ttgagagaga agtaggacca gcagaccatc gggatggtgg     3120

aggctgtgaa ggccgtgagc tctgggagcc cacactattt attggtaatc caacaaagaa     3180

acagatggtg agaatgtgaa ggtcagaagg gcaccttgca ttaagcacat gatttacagc     3240

tgtgatggtt tagcatttgc tctgctactt gagatgatgg agagcaggtt cttttaactc     3300

aagttacagt cgatcctggg agagcaagga gccagcaagt ctagacattc cagagccaca     3360

ggccctggat tttatccaag ccacgaggga ttttatgccc tgggcttaga ttatggtgcg     3420

tcagggcagc cttccaccct ttagcacaga gcttggtgtt ccaaagacca caaggggttt     3480

tagacccttg accctggaca tattccaaga ctcttttaca ttatgtcaga atgcaagccc     3540

tgcctcagct tctcccaaca ctcagctttt cgcaacataa tcccagcact ttggaacgct     3600

gggtggattg cttgaaccca ggagttcgag accatcctgg gcaatatggc aaaaccccat     3660

ctttaccaaa aataagctgg gtgtggtgga acatgcctgt ggtcccagct tcttgggagg     3720

ctgaggtggg aggattgctt gaacccggga ggtagaggct gcaatgggcc atgatcacga     3780

tcctgcactc cagcctgggc aacagagaga gacagtccct ggcccactgc ccccttccct     3840

ggcccagtct caaaaaaaat gaggctgggc gtggtggctc acatctgtaa tcccagccaa     3900

ggctggcaga tcacttgagg ccaggagttc tgagaccagc ctggcttaca tggtgaaacc     3960

ccatctctac taaaaataca aaaactagcc aggcatggtg ggaggcacct gtaatcccag     4020

ctacttggga ggctgaagca ggagaatcac tttaacccgg gaggtggagg ttgcagtgag     4080

ctgagatcac accactgcac tccagcctgg gcggcagagc aaaactgaaa aaaa           4134


<210> 4648
<211> 1809
<212> DNA
<213> Homo sapiens

<400> 4648
atggccgagt tcagggtcag ggtgtccacc ggagaagcct tcggggctgg cacatgggac       60

aaagtgtctg tcagcatcgt ggggacccgg ggagagagcc ccccactgcc cctggacaat      120

ctcggcaagg agttcactgc gggcgctgag gaggacttcc aggtgacgct cccggaggac      180

gtaggccgag tgctgctgct gcgcgtgcac aaggcgcccc cagtgctgcc cctgctgggg      240

cccctggccc cggatgcctg gttctgccgc tggttccagc tgacaccgcc gcggggcggc      300

cacctcctct tcccctgcta ccagtggctg gagggggcgg ggaccctggt gctgcaggag      360

ggtacagcca aggtgtcctg ggcagaccac caccctgtgc tccagcaaca gcgccaggag      420

gagcttcagg cccggcagga gatgtaccag tggaaggctt acaacccagg ttggcctcac      480

tgcctggatg aaaagacagt ggaagacttg gagctcaata tcaaatactc cacagccaag      540

aatgccaact tttatctaca ggctggctct gcttttgcag agatgaaaat caaggggttg      600

ctggaccgca aggggctctg gaggagtctg aatgagatga aaaggatctt caacttccgg      660

aggaccccag cagctgagca cgcatttgag cactggcagg aggacgcctt cttcgcctcc      720

cagttcctga atggtctcaa ccctgtcctg atccgccgct gtcactacct cccaaagaac      780

ttccccgtca ctgatgccat ggtggcctca gtgttgggtc ctgggaccag cttgcaggct      840

gagctagaga agggctccct gttcttggtg gatcacggca tcctctctgg catccagacc      900

aatgtcatta atgggaagcc tcagttctct gcggccccaa tgaccctgct ataccagagc      960

ccaggctgcg ggccgctgct gcctctcgcc atccagctca gccagacccc cggcccaaac     1020

agccccatct tcctgcccac tgatgacaag tgggactggt tgctggccaa gacctgggtg     1080

cgcaatgccg agttctcctt ccatgaggcc ctcacgcacc tgctgcactc acatctgctg     1140

cctgaggtct tcaccctggc taccctgcgt cagctgcccc actgccaccc tctcttcaag     1200

tccacaggca tcggcattga aggcttctct gagttgatac agaggaacat gaagcagctg     1260

aactattctc tcctgtgtct gcctgaggat atccggaccc gaggagttga agacatccca     1320

ggctactact accgtgatga tgggatgcag atctggggta taccctcctc actggagacc     1380

cgggaagccc tggtgcagta tgtcaccatg gtgatattca cctgctccgc caagcatgcg     1440

gctgtcagtg cagggcagtt tgactcctgt gcttggatgc ccaacctgcc acccagcatg     1500

cagctgccac cacccacctc caaaggcctg gcaacatgcg agggcttcat agccaccctc     1560

ccacctgtca atgccacatg tgatgtcatc cttgctctct ggttgctgag caaggagcct     1620

ggagaccaaa ggcccctggg cacctatccg gatgagcact tcacagagga ggcccctcgg     1680

cggagcatcg ccaccttcca gagccgcctg gcccagatct cgaggggcat ccaggagcgg     1740

aaccagggcc tggtgctgcc ctacacctac ctagaccctc ccctcatcga gaacagcgtc     1800

tccatctaa                                                             1809


<210> 4649
<211> 2204
<212> DNA
<213> Homo sapiens

<400> 4649
accagccaac gtccgggaaa aacgagtaag tacaggttcc ttctgccaat ccccgccggc       60

cacagctaac tttcccgccc ggcccctttc tgtcataatt gaggtgtcca caaccagcca      120

atcaggaacg cgagagtatc ccgcgtttgc tttcgctcgc cgaggcgcgt atcagtcgga      180

attttgggga gccaaccgcg ccgtctgtcc ctggcaagcc agcggcggtt taaaggaggt      240

ggcgggaagc ctgtgtgtgc ttcaaatcgt caccctcatg gtcgctccgg tttttcacga      300

ctgaaaacaa catagcaaaa taagccaaga tgtctgtgga tccaatgacc tacgaggccc      360

agttctttgg cttcacgcca caaacgtgca tgcttcggat ctacattgca tttcaagact      420

acctatttga agtgatgcag gccgttgaac aggttattct gaagaagctg gatggcatcc      480

cagactgtga cattagccca gtgcagattc gcaaatgcac agagaagttt ctttgcttca      540

tgaaaggaca ttttgataac ctttttagca aaatggagca actgtttttg cagctgattt      600

tacgtattcc ctcaaacatc ttgcttcctg aagataaatg taaggagaca ccttatagtg      660

aggaagattt tcagcatctc cagaaagaaa ttgaacagtt acaggagaag tacaagactg      720

aattatgtac taagcaggcc cttcttgcag aattagaaga gcaaaaaatt gttcaggcca      780

aactcaaaca gacgttgact ttctttgatg agcttcataa tgttggcaga gatcatggga      840

ctagtgattt tagggagagt ttagtatccc tggttcagaa ctccagaaaa ctacagaaca      900

ttagagacaa tgtggaaaag gaatcgaaac gactgaaaat atcttaattg ctcagtagtc      960

aaaaggagga gcctgtcaaa aagtagaatc ataaggactg ttcaaaccat aaggactgtt     1020

caaatcatac cagtgactgt tcaaaccaac catacttttt attagatttg ctttgtcaac     1080

tctttcttgt attctgtgtt ttcctctttt ttggtccact ttgctgaggt atgaagtgta     1140

ctactttgaa ctaggctgaa gcatctgagt cttctaataa gtgggaaggg atccaacaaa     1200

gaagccatga ccagttaaag atatttgcag agttacacct tggtcataag tcctttgtga     1260

ccttgattat tttggcttac tctttggatg agaccagaca agaaaaggat taaacgggtg     1320

gctcctttaa tattattatt attgtttttg agacaaggtc cctttctgtc acccaggtta     1380

gagtagattt cagtggcaca atcttggctc actgcaacct ctgtgtcctg ggctcaagtg     1440

atcctcctgc ctcagcctcc caagtagcta ggaccacagg tgcgtgtcac catgcttggc     1500

taattttttt gcagaaacga ggcctcacta tattgtccag gctgagtggc tcttttatta     1560

accagtcatt acactgcgga acagccaaca tagagtactt gctctcgtcc tgtgaatttt     1620

ctttcatgag ggagtcaata tgtagtggaa agaagcatgt agcaaaaaag acaaccttga     1680

tctttaataa aaaagaagtt ggtttatttc caaaataaat cccctgacaa aaaacctggt     1740

gatgttaagc aattgactgt cttagagtcc agcagaagac cttagacaaa aaaagcagaa     1800

cccactggag tagaaaagga agcatgtagc atatactcag tagtgaaatt taattttact     1860

gactgttagg tatctatgcc aatttgtttt catacttcag ttggttttgg aatctgcctt     1920

atacctaata tttatttatt cacactcata agcatcaaat atttaatgcc ctcagtggga     1980

aatttgtgtt taaactcaat ggaatctaat atttctttat gtcgttagtc cctgtaaaat     2040

gttaggtcac ccaaggaaag gggagaaata gcaatggttg ttcctaaggt attgcttgcc     2100

ctccatgtct tcctaaagag cagaacttgg agtttctcct ttatgtagag aagaagtaac     2160

ttagggtgta tttgcaatga aatattcata gatattgaaa gctt                      2204


<210> 4650
<211> 618
<212> DNA
<213> Homo sapiens

<400> 4650
ccgcaggacc ccaaaaccca atgatcctgc agcagccctt gcagcgaggc ccccagggag       60

gggcccagcg cctcccgcgg gccgccttgg gggtgacttg gggcctggac gccagggagc      120

ctctgcgcaa gcagtttctg tctgaggaga acatggccac ccacttctct caactcagcc      180

tgcacaatga ccacccctac tgcagccccc ccatgacctt ctccccagcc ctgcccccac      240

tcaggagccc ttgctctgag ctgcttctct ggcgctatcc tggcagcctc atccctgagg      300

ccctccgtct gctgaggctg ggggacaccc ccagtccccc ctaccctgca accccagctg      360

gggacataat ggagctctga gtgctggtgg acagtgcccc tcccaccttc cttcttcccc      420

acaacagaag agaccagcga ctcccgcaaa gggacaaggt tcctccctct cctgcagagt      480

aggcatctgg gcaccaagac cttccctcaa cagaggacac tgagcccaac ggagttctgg      540

gatgggaggg gtgggagcat gggaagggag gcatcccacc cccaagaaga actgaataaa      600

gattgctgag caaaggaa                                                    618


<210> 4651
<211> 1892
<212> DNA
<213> Homo sapiens

<400> 4651
ctcacgggag tcctccgccc gggcgtccgg aacagtcgac ggcagactcc ggcccgctga       60

gccacccgag gggtcccgtg gcctccgcgg acccggaatc tgggccctcg cggacccgcg      120

ccccgcccag tcgccccagc ccgtccactg ctctgttcgc cagggcttcc ccacacccac      180

ggagtgaagt cagccgcggc cctgcctggg aggaacttac cgtctaccgg gaaaggtggc      240

cagcagatgt gtcgggcctg gtgagagggg cctcctgcac tggccatgcc catgcccacg      300

gagggcaccc cgccacctct gagtggcacc cccatcccag tcccagccta cttccgccac      360

gcagaacctg gattctccct caagaggccc agggggctca gccggagcct cccacctccg      420

ccccctgcca agggcagcat tcccatcagc cgcctcttcc ctcctcggac cccaggctgg      480

caccagctgc agccccggcg ggtgtcattc cggggcgagg cctcagagac tctgcagagc      540

cctgggtatg acccaagccg gccagagtcc ttcttccagc agagcttcca gaggctcagc      600

cgcctgggcc atggctccta cggagaggtc ttcaaggtgc gctccaagga ggacggccgg      660

ctctatgcgg taaagcgttc catgtcacca ttccggggcc ccaaggaccg ggcccgcaag      720

ttggccgagg tgggcagcca cgagaaggtg gggcagcacc catgctgcgt gcggctggag      780

caggcctggg aggagggcgg catcctgtac ctgcagacgg agctgtgcgg gcccagcctg      840

cagcaacact gtgaggcctg gggtgccagc ctgcctgagg cccaggtctg gggctacctg      900

cgggacacgc tgcttgccct ggcccatctg cacagccagg gcctggtgca ccttgatgtc      960

aagcctgcca acatcttcct ggggccccgg ggccgctgca agctgggtga cttcggactg     1020

ctggtggagc tgggtacagc aggagctggt gaggtccagg agggagaccc ccgctacatg     1080

gcccccgagc tgctgcaggg ctcctatggg acagcagcgg atgtgttcag tctgggcctc     1140

accatcctgg aagtggcatg caacatggag ctgccccacg gtggggaggg ctggcagcag     1200

ctgcgccagg gctacctgcc ccctgagttc actgccggtc tgtcttccga gctgcgttct     1260

gtccttgtca tgatgctgga gccagacccc aagctgcggg ccacggccga ggccctgctg     1320

gcactgcctg tgttgaggca gccgcgggcc tggggtgtgc tgtggtgcat ggcagcggag     1380

gccctgagcc gagggtgggc cctgtggcag gccctgcttg ccctgctctg ctggctctgg     1440

catgggctgg ctcaccctgc cagctggcta cagcccctgg gcccgccagc caccccgcct     1500

ggctcaccac cctgcagttt gctcctggac agcagcctct ccagcaactg ggatgacgac     1560

agcctagggc cttcactctc ccctgaggct gtcctggccc ggactgtggg gagcacctcc     1620

accccccgga gcaggtgcac acccagggat gccctggacc taagtgacat caactcagag     1680

cctcctcggg gctccttccc ctcctttgag cctcggaacc tcctcagcct gtttgaggac     1740

accctagacc caacctgagc cccagactct gcctctgcac ttttaacctt ttatcctgtg     1800

tctctcccgt cgcccttgaa agctggggcc cctcgggaac tcccatggtc ttctctgcct     1860

ggccgtgtct aataaaaagt atttgaacct tg                                   1892


<210> 4652
<211> 1806
<212> DNA
<213> Homo sapiens

<400> 4652
cacgggccgt tccccctcac gggagtcctc cgcccgggcg tccggaacag tcgacggcag       60

actccggccc gctgagccac ccgaggggtc ccgtggcctc cgcggacccg gaatctgggc      120

cctcgcggac ccgcgccccg cccagtcgcc ccagggcttc cccacaccca cggagtgaag      180

tcagccgcgg ccctgcctgg gaggaactta ccgtctaccg ggaaaggtgg ccagcagatg      240

tgtcgggcct ggtgagaggg tgaggcgaga cggcccgatc gcccagggcc ccggaagctg      300

cggaggtcac ccccgcctgg ccttagctca gggacaccct ggattcacgt gggagcccct      360

gctcctgcct cccccgtccc accactgagg ctgttgggcc aggccagtca tgctagaacg      420

ctggcaccag ctgcagcccc ggcgggtgtc attccggggc gaggcctcag agactctgca      480

gagccctggg tatgacccaa gccggccaga gtccttcttc cagcagagct tccagaggct      540

cagccgcctg ggccatggct cctacggaga ggtcttcaag gtgcgctcca aggaggacgg      600

ccggctctat gcggtaaagc gttccatgtc accattccgg ggccccaagg accgggcccg      660

caagttggcc gaggtgggca gccacgagaa ggtggggcag cacccatgct gcgtgcggct      720

ggagcaggcc tgggaggagg gcggcatcct gtacctgcag acggagctgt gcgggcccag      780

cctgcagcaa cactgtgagg cctggggtgc cagcctgcct gaggcccagg tctggggcta      840

cctgcgggac acgctgcttg ccctggccca tctgcacagc cagggcctgg tgcaccttga      900

tgtcaagcct gccaacatct tcctggggcc ccggggccgc tgcaagctgg gtgacttcgg      960

actgctggtg gagctgggta cagcaggagc tggtgaggtc caggagggag acccccgcta     1020

catggccccc gagctgctgc agggctccta tgggacagca gcggatgtgt tcagtctggg     1080

cctcaccatc ctggaagtgg catgcaacat ggagctgccc cacggtgggg agggctggca     1140

gcagctgcgc cagggctacc tgccccctga gttcactgcc ggtctgtctt ccgagctgcg     1200

ttctgtcctt gtcatgatgc tggagccaga ccccaagctg cgggccacgg ccgaggccct     1260

gctggcactg cctgtgttga ggcagccgcg ggcctggggt gtgctgtggt gcatggcagc     1320

ggaggccctg agccgagggt gggccctgtg gcaggccctg cttgccctgc tctgctggct     1380

ctggcatggg ctggctcacc ctgccagctg gctacagccc ctgggcccgc cagccacccc     1440

gcctggctca ccaccctgca gtttgctcct ggacagcagc ctctccagca actgggatga     1500

cgacagccta gggccttcac tctcccctga ggctgtcctg gcccggactg tggggagcac     1560

ctccaccccc cggagcaggt gcacacccag ggatgccctg gacctaagtg acatcaactc     1620

agagcctcct cggggctcct tcccctcctt tgagcctcgg aacctcctca gcctgtttga     1680

ggacacccta gacccaacct gagccccaga ctctgcctct gcacttttaa ccttttatcc     1740

tgtgtctctc ccgtcgccct tgaaagctgg ggcccctcgg gaactcccat ggtcttctct     1800

gcctgg                                                                1806


<210> 4653
<211> 1221
<212> DNA
<213> Homo sapiens

<400> 4653
gctcaggccc cgccctcaga cgagcaccgc ccgccggctc ctcccgcggc tcgaatcgcc       60

gtctctctcc tccccgcccc gccgagttct agaattcgcc gcgcagctgc ttcagcccct      120

cagccccagc cggaccctcg ggtcctcatc caccctcgca ggcgcaggcc gtggctaccc      180

cgaagtcaac tgtggaggat ccttcctggc ttccttcagc tccatcctgc ccttggatct      240

agcaccaaaa aggagactaa ctacccagcc ccgtccagtc atgcaggtgc aggatgatgg      300

agtcaacctc atcccctttg ccaagtgttc cagggtggtc agccgatctc cacccccaag      360

gttgccttcc cagagcctca gacccatgcc ccagcgttat ggagatgtct tctggaagaa      420

ccttaatcaa aggcccaccc ccacttggct ggaggagcag cacattccac ccatgctgct      480

cccaccccct gaaatgcttt ggagaagaaa gaagaggagg ccatgtttgg aaggaatgca      540

gcagcagggc cttgggggag tccccgcccg ggtgagggct gtcacttacc acctggagga      600

cctaagaagg cgtcagagca tcatcaacga actgaagaag gcccagtggg gcagctctgg      660

ggctgcatct gagccagtgg tgcttggcga agagggctgt ggattcccca gcaccaatga      720

ataccctgat ctggaagagg agagagcaac ctatccacag gaagaggacc gttttctcac      780

tcctggcagg gcccagctgc tttggtctcc ctggagcccc ctggatcagg aggaggcttg      840

tgcctccagg cagctgcact ctctggcctc gttcagcact gtcacagcca gaaggaaccc      900

ccttcacaat ccctggggga tggagttggc agcgtctgaa gagtaaggag aaaccaccga      960

tgccgagagg ctagtggtgc cccagggacc caagactagt tccgtcacta gagtcaccct     1020

cattgctgac atgaaggcgt ttccccttcc ttcgtctctc caactgcctt tcccatcctc     1080

tgaactaggc attaacagcc cccgtgggct cccatctcaa cccaccgctc tcacaggagc     1140

accccaagtc ctgttttcct ccaggccccg ctcctggcct tgtattctct ctgctctgtt     1200

attaaaaagc aagcaagtgg a                                               1221


<210> 4654
<211> 2579
<212> DNA
<213> Homo sapiens

<400> 4654
atggaggccg cggcggtgac ggtcacccgg tcggctacac ggcggcggcg gcggcagctg       60

caggggctgg cggccccgga ggcggggacg caggaggagc aggaggatca ggagccgcgg      120

ccgcggcggc ggcggccggg aaggagcatc aaagatgaag aagaagagac agtctttcga      180

gaggtggtca gtttttcccc ggaccccctg ccagttagat attatgacaa ggacaccacc      240

aaaccaatca gcttttactt gtcttcgctg gaggagctct tggcgtggaa gccccgcttg      300

gaggatggct ttaatgtggc cctggagccc ctggcgtgtc gccagccccc tctgagcagc      360

cagaggcccc ggactttgtt gtgtcatgac atgatgggcg ggtacctgga tgacaggttc      420

attcagggct cggtggtgca gactccctat gctttctacc actggcagtg catcgacgtc      480

tttgtgtact tcagccacca caccgtcacc attcccccag tgggctggac caacactgcc      540

cacaggcatg gggtctgcgt gctggggact ttcatcacgg agtggaatga agggggaagg      600

ctctgtgaag ccttcctggc cggggatgag cgctcgtacc aggcagtggc tgaccggctg      660

gtccagatca ctcagttttt tcgttttgat ggctggctga tcaacatcga gaactcgctg      720

agtctggccg ctgtggggaa catgcctcct ttcctgcggt acctcaccac acagctgcac      780

cggcaggtcc cagggggcct ggtgctctgg tatgacagcg tggtgcaaag tgggcagctc      840

aaatggcaag acgaactcaa ccagcacaac agggtcttct ttgattcctg cgacggcttc      900

ttcactaact ataactggcg ggaggagcac ttggagcgga tgctggggca ggctggggag      960

cgccgggctg atgtgtacgt gggcgtggat gtgtttgctc gagggaacgt ggtcggaggc     1020

cgattcgaca cagacaagtc gttggagctg atccgaaagc atggcttctc cgtggctttg     1080

tttgcccccg gctgggtgta tgagtgtctg gagaagaagg atttcttcca gaaccaggac     1140

aagttctggg gccgactgga gcgttatctg cccacacata gcatctgctc cttgcctttc     1200

gtcacgtcct tctgcctggg catgggtgca cggagggtct gctatggcca ggaagaggcg     1260

gtagggccct ggtaccacct gagcgcccag gagatccagc ccttgtttgg agaacacagg     1320

ctgggagggg atggccgggg ctgggtgagg acgcactgct gcctggagga tgcctggcac     1380

ggaggcagct ccctgctcgt ccggggtgtg atcccaccgg aggttggaaa tgtggctgtg     1440

aggttatttt ccctgcaggc cccagtgcca cccaagattt acctgtccat ggtgtataag     1500

cttgaggggc ccacggacgt cacagttgct ttggagctga ccacagggga tgccggcagc     1560

tgccacatcg gtggcatctc agtgttgaac gcagaaacaa gctcaagaca cagcctccga     1620

cccctccggg tgccccccac caagctggcc agatgggtgg gccgctgcgg ccggcagctg     1680

agtgggggct gggtccagca ctgctacgag gtgagcctgc gtgggtgcct gctgctagac     1740

ctcctcgttt gcttctcacg gccgccgggt agtcgggagg aggagagctt cacctgtcgg     1800

cttggagaga tccaggtggt ggacgctgcc agcctgctgg cccctctgcc ccaggtgcag     1860

gccgtcacca tctctcacat ccgctggcag ccatccgcct ctgagcggga ggggccccct     1920

gctctgctcc agctcagctg caccctgcac tggtccttcc tcctctcaca agtccgttgc     1980

ttccgaatcc actgctgggg agggatgagt gatgactctc cgggcaggga gctgccgagg     2040

ccagagatgc ccatgttcct ggggttggct tttgccaccc agtaccggat agtggacctg     2100

ctggtggaag ccgccgggcc cggccaggat cgtcgcatgg aatttctggt ggagcctgtc     2160

cccaaggaag ggttccgggt acctcaggcc gagtggggca gggcagttct gctttattca     2220

gcccctgcat gagcggatgc taaggccggg tggtctcctg gcctcgggct gaggcctctt     2280

cccggctgtc tgcccctggc ctgcgctgga cctgctaagt gcccacagtg gcagcgaggt     2340

cccggtcccg gggctggggt gggagacccc gggctgagtg ctgtggcttt ctggtggggg     2400

gcgatggaaa caggaaacca agcagtggga tcgcagcgtt ggtcactgcg aggcgagtgg     2460

cgggctttct gtttctgcct tgtccctccc cacggtacct ggttcccagg tgaaaatgaa     2520

aggaggggag aagttgagaa cagaacattc cataaaggat atttcctaat aggctgcaa      2579


<210> 4655
<211> 1406
<212> DNA
<213> Homo sapiens

<400> 4655
gggacggggt cagtgccaag atgtcgacgg cggcggttcc ggagctgaag cagatcagcc       60

gggtggaggc gatgcgccta gggccgggct ggagccactc gtgccacgcc atgctgtacg      120

ccgccaaccc tgggcagctc ttcggccgca tccccatgcg cttctcggtg ctgatgcaga      180

tgcgtttcga cgggctgctg ggcttccccg ggggcttcgt ggaccggcgc ttctggtcgc      240

tggaggacgg cctgaaccgg gtgctgggcc tgggcctggg ctgcctgcgc ctcaccgagg      300

ccgactacct gagctcgcac ctgaccgagg gcccacaccg cgtcgtggcg cacctgtacg      360

cgcggcagct gacgctggag cagctgcacg ccgtggagat cagcgcggtg cactcgcgcg      420

accacggcct ggaggtgggg ccgccgcccg ggccccgccc cccgccccgg ggtttggctc      480

tggccccgtg gaaggcaccg atgggtgctg ggcctcgtgc gggtcccgct gtacacccag      540

aaggaccgag tcggaggctt ccccaacttc ctgagcaacg ccttcgtgag cacggctaag      600

tgccagctcc tctttgccct caaggtgctc aacatgatgc ccgaggagaa gctggttgag      660

gccctggctg cagccaccga gaagcagaag aaggccctgg agaagttgct cccggcctcc      720

tcttgagggc tgcctgagct ggtggcaccc tcccctgggc cggaagactg ggaattcctg      780

ctaagtgtgg cttctagagt gtttgtgtgt accccgcttc tgactgccta gggcgagtgg      840

gcatcctgtc atcatctcca ctgtcccaag cagtcactag gtggcggccg ggccagctgg      900

aacccagccc atcctctcag gcagagcagg gtggtccggg cacactgggc ctgcctctcc      960

agcctcagga tgctcttgtt tattctgggc tcagaccctc ctcttgtacg tctcatcaca     1020

gctggtagag acccaggagt gcctgattgt cccacagggg tggcgcacag ctctgggacc     1080

actcagaaga tgggatgtgt gggtggagga tgccttgtct cggtcagctc attcctgcct     1140

ccttcctgag ccagttcagg gcctggggga gagccagctt ggggtaggaa gttaataata     1200

ctgttaattt gggttgttgt tggatttact ttgctagatt ttctctttca ccacgtgtga     1260

actgtgggtg aggtttcaaa gtagcttcac cccacgtggc ttggttccca gggacagtca     1320

gggcctcggg ggcccagcta tgtacaacga agctgtcgaa ggagaagaca ataaagtcgc     1380

tccgcagctg ctctgtgtgt ttctca                                          1406


<210> 4656
<211> 2763
<212> DNA
<213> Homo sapiens

<400> 4656
atactccggt tgtgggcggg accagacggt acctaggggg atccgggcgc agccaatcct       60

ggccctagga ttgtgttggg gggcttggca ggcggtgtcc cgacccccct ttctgggcat      120

cctggggatg accccagcgc cgggcccggc gccggccgcc tgatgccagg cgagctgagc      180

tggggatgct ggaacgaagg gcgttgctat ggcaacggga ggcagggcct ggttgggggg      240

accgggcccg ggctgggacc gggggggccg gcggtggctg tggtggggcg atggcggagc      300

gcggcccggc cttctgcggc ctgtacgaca cgtcctcgct gctgcgatac tgcaacgatg      360

acaatttgtc gggcacgagc ggtatggaag tggacgaccg cgtgtcggcg ctggagcagc      420

ggctgcagtt acaggaagac gagctggcgg tcctaaaggc ggcgctggcg gatgctctgc      480

gtcgcctgcg ggcatgcgaa gaacagggag cggcgctacg cgcgcggggc acccccaagg      540

gccgggcgcc tccgcgctta ggcaccactg cctcggtgtg tcagctcttg aaaggccttc      600

ccaccaggac gccccttaat ggctcgggac ccccgcggcg cgtgggtggc tatgccacgt      660

ccccatcctc tcccaagaag gaggcgacct ccgggcgcag cagtgtccgc cgctacttgt      720

caccagagcg cctcgcctcg gtgcgccgtg aggacccccg cagccggacc acatcctcca      780

gcagcaactg tagcgccaaa aaggaaggca aaaccaaaga agttatcttc agtgtggagg      840

atggctccgt gaaaatgttc ctgaggggcc gccctgtgcc catgatgatc ccagacgagc      900

tggcacccac ctacagcctg gacacacgct cggagctgcc ttcttgccgg ctcaagctgg      960

agtgggtcta tggctaccgt ggccgagact gccgggccaa cctttatttg ctgcccaccg     1020

gggagatagt gtactttgtg gcctccgtag ccgtgctata cagcgtggag gagcagaggc     1080

agcgacacta cctgggacac aacgatgaca tcaaatgctt ggccatccac ccagatatgg     1140

tcaccatcgc cacgggacag gtggcgggaa ccactaagga agggaagccg ctgccgcccc     1200

acgtgcgcat ctgggactca gtttccctct ccaccttaca cgtgctgggc ttgggggtgt     1260

ttgacagagc cgtgtgctgt gtgggcttct ccaaatctaa tggaggcaac ctgctgtgtg     1320

cagtggatga atccaatgat cacatgctct cggtgtggga ctgggccaag gagaccaagg     1380

tggtggatgt caagtgctcc aatgaggctg tattggtggc caccttccac cccacggacc     1440

ccactgtgct tatcacctgc gggaaatctc acatctactt ctggaccttg gaggggggca     1500

gcttgagcaa gcggcaaggc ctctttgaga aacatgagaa accgaagtat gtgctgtgtg     1560

tgaccttttt ggaaggtggc gacgtggtca cgggggactc tggggggaac ctctatgttt     1620

ggggcaaagg tgggaaccgt atcacacagg cggtgctggg cgcccacgac ggcggcgtgt     1680

ttgggctctg cgccctgcgg gacgggacgc tggtgtctgg agggggccgt gatcggcggg     1740

tggtcctctg gggttctgac tacagcaagc tgcaggaagt ggaggtccct gaggactttg     1800

gccctgtgcg caccgtggca gagggccacg gagacacact gtacgtgggg accacccgca     1860

attccatcct gcagggctcc gtgcacacag gcttctcact gctggtccag ggccatgtgg     1920

aagagctgtg gggcctggcc acacacccca gtcgggccca gtttgtgacc tgcgggcagg     1980

ataagctggt gcatctatgg agctcagatt cccaccagcc cctgtggagc aggatcatcg     2040

aggaccctgc ccgctcagcc ggcttccacc ccagtggctc tgtcctggct gtgggtacag     2100

tgactggcag atggctgctg ctggacacgg agacccatga cctggtggct atccacacag     2160

acggcaatga acagatctca gtggtcagct tctccccaga cggggcgtac ctggccgtgg     2220

gctcccacga caacttggtg tacgtgtaca cggtggacca gggcggccgc aaggtcagcc     2280

gcctgggcaa gtgctcgggc cattccagtt ttatcaccca cctggattgg gcccaggaca     2340

gcagctgctt tgtcaccaac tccggggact atgagattct gtactgggac ccggctacct     2400

gtaagcagat caccagtgcg gatgctgtga ggaacatgga atgggccaca gctacttgtg     2460

tcctagggtt tggggtgttt gggatctggt ctgagggggc ggacggcact gatatcaacg     2520

ctgtggcccg ctctcatgat gggaagttgc tggcttcagc tgatgacttt ggcaaagttc     2580

acctgtttag ctacccctgc tgtcagcctc gagccctcag ccacaagtac ggtggacaca     2640

gcagccatgt gacaaatgtg gccttcttgt gggatgacag catggccctg accacagggg     2700

gcaaggacac cagtgtgcta cagtggcggg tggtctgatg cggccaggga agagtcaggt     2760

gtc                                                                   2763


<210> 4657
<211> 4217
<212> DNA
<213> Homo sapiens

<400> 4657
ccgacgaaag gtgtcaccac agtgatggca gtggaggaca gcacgctgca agtagtggta       60

cgggtgcggc cccccacccc tcgggagctg gacagtcagc ggcggccagt ggttcaggtg      120

gtggacgagc gggtgctggt gtttaaccct gaggagcccg atggagggtt ccctggcctg      180

aaatggggtg gcacccatga tggccccaag aagaagggca aagacctgac gtttgtcttt      240

gaccgggtct ttggcgaggc ggccacccaa caggacgtgt tccagcacac cacgcacagc      300

gtcctggaca gcttcctcca gggctacaac tgctcagtgt ttgcctacgg ggccaccggg      360

gctgggaaga cacacaccat gctgggaagg gagggggacc ccggcatcat gtacctgacc      420

accgtggaac tgtacaggcg cctggaggcc cgccagcagg agaagcactt cgaggtgctc      480

atcagctacc aggaggtgta taatgaacag atccatgacc tcctggagcc caaggggccc      540

cttgccatcc gcgaggaccc cgacaagggg gtggtggtgc aaggactttc tttccaccag      600

ccagcctcag ccgagcagct gctggagata ctgaccaggg ggaaccgtaa ccgcacgcag      660

caccccactg atgccaacgc gacttcctcc cgctcccatg ccatcttcca gatctttgtg      720

aagcagcagg accgggttcc aggactgacc caggctgtcc aggtggccaa gatgagcctg      780

attgacctgg ctggctcaga gcgggcatcc agcacccatg cgaaggggga gcggctgcgg      840

gagggggcca acatcaaccg ctctctgctg gcgctcatca acgtcctcaa tgccttggcc      900

gatgcaaagg gccgcaagac ccatgtgccc taccgggaca gcaaactgac ccgcctgctc      960

aaagactccc tcgggggcaa ctgccgcaca gtgatgatcg ctgccatcag cccctccagc     1020

ctgacctacg aggacacgta caacaccctc aaatatgccg accgggccaa ggagatcagg     1080

ctctcgctga agagcaatgt gaccagcctg gactgtcaca tcagccagta tgctaccatc     1140

tgccaacagc tccaggctga ggtagccgct ctgaggaaga agctccaagt gtatgagggg     1200

ggaggccagc ccccaccaca ggacctccca ggatctccca agtcgggacc accaccagaa     1260

caccttccca gctccccctt gccaccccac cctcccagcc agccctgcac cccagagctc     1320

cctgcagggc ctagagccct tcaagaggag agtctgggga tggaggccca ggtggagagg     1380

gccatggaag ggaactcttc agaccaggag cagtccccag aggatgagga tgaaggccca     1440

gctgaggagg ttccaaccca gatgccagag cagaacccca cacatgcact gccagagtcc     1500

cctcgcctga ccctgcagcc caagccagtc gtgggccact tctcagcacg ggaactggat     1560

ggggaccgtt ctaagcagtt ggccctaaag gtgctgtgcg ttgcccagcg gcagtactcc     1620

ctgctccaag cagccaacct cctgacgccc gacatgatca cagagtttga gaccctacag     1680

cagctggtgc aagaggaaaa aattgagcct ggggcagagg ccttgaggac ttcaggcctg     1740

gccagggggg cacctctggc tcaggagctg tgttcagagt caatccctgt gccgtctcct     1800

ctctgcccag agcctccagg atacactggc cctgtgaccc ggactatggc gaggcgactg     1860

agtggccccc tgcacaccct gggaatcccg cctggaccca actgcacccc agcccagggg     1920

tcccgatggc ccatggagaa gaagaggagg agaccaagcg ccttggaggc agacagtccc     1980

atggccccaa agcggggcac caagcgccag cgccagtcct tcctgccctg cctaaggaga     2040

gggtctctgc ctgacaccca accttcacag gggcccagca cccccaaagg agaaagggcc     2100

tcctccccct gccattcccc tcgcgtttgc ccagccacag tcatcaaaag ccgggtgccc     2160

ctgggccctt ccgccatgca gaactgctcc accccgctgg ctctgcccac tcgagacctc     2220

aatgccacct ttgatctctc tgaggagcct ccctcaaagc ccagtttcca tgaatgcatt     2280

ggctgggaca aaatacccca ggagctgagc aggctggacc agcccttcat ccccagggca     2340

cctgtgcccc tgttcaccat gaagggcccc aagccaacat cttccctccc tgggacctct     2400

gcctgcaaga agaagcgcgt tgcgagttcc tcagtctccc atggccgcag ccgcatcgcc     2460

cgcctcccca gcagcacttt gaagaggcca gctgggcccc ttgtactccc aggtgactgg     2520

cactagggac agggatagcc tgggccatgg aggccgatga agacaagaag gaggagggga     2580

cggggagctg agacccagaa gaaaggaggg cctagggtat tgccaagcat ctcagggatg     2640

ctgctgatga gacaggtggg aggtgggctg gaggacgggg acagagcgtc actttccttc     2700

ctcgctgcac tccccgccac ccatccaact ggcctgcaga gctgcccttg agtcccctgt     2760

gccctagcaa ccggaggaat ggaaaggacc tcatcagggt ggggagagca ctctcagcag     2820

ggaacggcgt caccaaggtg tcctgaccgc cagaatgtcc tgaccaccaa ggtgtcctaa     2880

cctaccggcc cctctgctgg atacccctct tggacctgta gccacctgca ccaggagctg     2940

gacctgcctt ccttacctgg gagcaattag tgccaacaca cctttgctgt attaacatcc     3000

ctccccagac atccatcctg ctactcaccc tctgttaatc tcctgttaca ctcagcttct     3060

tggcatgtac atattcattt gtgagtgtta atgtgctgct gttttttgtt ttttggtggt     3120

ttttgttttt tgtttttttt gttttgagat ggagtcttac tctgtcgccc aggctggagt     3180

gcagtggtac gatcttggct cactgcaacc tccgcctcct gggttcaagt aattctcctg     3240

cctcagcttt ccaagtagct gggattacag gcacccatca ccacacccag ctaattttcg     3300

tctttttaat agagaggggg tttttccatg ttggccaggc tggtcttgaa ctcctgacct     3360

caggtgatcc gcctgcctca gcttcccaaa gtgctgagat tacaggcatg agctaccacg     3420

cctggcccgt gttgctgttt taaaggtgct gccatgttcc cccatctttt ttttttttga     3480

gatggagtct cgctctgtcg cccaggctgg agtgcagtgg tggcgatctt ggctcactgc     3540

aagctccgcc tcccaggttc acaccattct cctgcctcag cctcccaagt agctgggact     3600

acaggcgccc accaccacgc ctggctaatt ttttgtattt ttagtagaga tggggtttca     3660

ccgtgttagc caggctggtc tcgatctgac ctcatgatcc acccgcctcg gcctcccaaa     3720

gtgctgggat tacaggcgtg agccactgcg cccggcctcc cctctcattt atgatgccct     3780

ctgtgcaggc agacggctct tgggctcttt tccccacctg tctctaacac aggccccacg     3840

gtgatggcca caggcagtag aggaggaatg aggatgggtt ggggagcggg gagtcgcggc     3900

ttggctcttc ctggtttctg agagggacat cttcatccct actccccttg gtccccaacc     3960

acagtcctgg tgaagatgtg gatgataatg gtgccttgat ttccaaatga agacagcttt     4020

attgcttaac tctattgtac ataggataca cgttcagtgt aaaataaagt gtaaagggga     4080

attcaggctt aatgctgcac ctagatataa atgctaatga tacttgggtt tatagccttc     4140

tgatccttta tttctgcata tatatataga tatatacata tatttttggt ataacaataa     4200

accgtctcca tccttgg                                                    4217


<210> 4658
<211> 9202
<212> DNA
<213> Homo sapiens

<400> 4658
gatatggtgt aagatacttc ttcaagattg gacagctggg gaccttcttc tgattaacct       60

taaaccaact tgtagccata gagacacctc acaaggttcc catttttgtt gttgttgttg      120

ttgattttct gctcacacct ttcctgacct tgcaaccatg tatggaagtg cccgctctgt      180

tgggaaggtg gagccgagca gccagagccc tgggcgttca cccaggcttc cacgttcccc      240

tcgcttgggt caccgtcgaa ccaacagtac gggagggagt tcgggaagca gtgttggagg      300

tggcagtggg aaaacccttt caatggaaaa tatacaatct ttaaatgctg cctatgccac      360

ctctggccct atgtatctaa gtgaccatga aaatgtgggt tcagaaacac ctaaaagcac      420

catgacactt ggccgttctg ggggacgtct gccttacggt gttcggatga ctgctatggg      480

tagtagcccc aatatagcta gcagtggggt tgctagtgac accatagcat ttggagagca      540

tcacctccct cctgtgagta tggcatccac tgtacctcac tcccttcgtc aggcgagaga      600

taacacaatc atggatctgc agacacagct gaaggaagta ttaagagaaa atgatctctt      660

gcggaaggat gtggaagtaa aggagagcaa attgagttct tcaatgaata gcatcaagac      720

cttctggagc ccagagctga agaaggaacg agccctgaga aaagatgaag cttccaaaat      780

caccatttgg aaggaacagt acagagttgt acaggaggaa aaccagcaca tgcagatgac      840

aatccaggct ctccaggatg aattgcggat ccagagggac ctgaatcagc tgtttcagca      900

ggatagtagc agcaggactg gcgaaccttg tgtagcagag ctgacagagg agaactttca      960

gaggcttcat gctgagcatg agcggcaggc caaagagctg tttcttcttc gaaagacatt     1020

ggaggaaatg gagctgcgta ttgagactca aaagcagacc ctaaatgctc gggatgaatc     1080

cattaagaag cttctggaaa tgttgcagag caaaggactt tctgccaagg ctaccgagga     1140

agaccatgag agaacaagac gactggcaga ggcagagatg cacgttcatc acctagaaag     1200

ccttttggag cagaaggaaa aagagaacag tatgttgaga gaggagatgc atcgaaggtt     1260

tgagaatgct cctgattctg ccaaaacaaa agctctgcaa actgttattg agatgaagga     1320

ttcaaaaatt tcctctatgg agcgtgggct tcgagacctg gaagaggaaa ttcagatgct     1380

gaaatcgaat ggtgctttga gtactgagga aagggaagaa gaaatgaagc aaatggaagt     1440

gtatcggagc cattctaaat ttatgaaaaa taaggtagaa caactgaagg aggaactaag     1500

ttcgaaagag gctcaatggg aggagctgaa aaagaaagcg gctggtcttc aggctgagat     1560

tggccaggtg aaacaggagc tgtccagaaa ggacacagaa ctactcgccc tgcagacaaa     1620

gctagaaaca ctcacaaacc agttctcaga tagtaaacag cacattgaag tgttgaagga     1680

gtccttgact gctaaggagc agagggctgc catcctgcag actgaggtgg atgctctccg     1740

attgcgtttg gaagagaagg aaaccatgtt gaataaaaag acaaaacaaa ttcaggatat     1800

ggctgaagag aaggggacac aagctggaga gatacatgac ctcaaggaca tgttggatgt     1860

gaaggagcgg aaggttaatg ttcttcagaa gaagattgaa aatcttcaag agcagcttag     1920

agacaaggaa aagcagatga gcagcttgaa agaacgggtc aaatccttgc aggctgacac     1980

caccaacact gacactgcct tgacaacttt ggaggaggcc cttgcagaga aagagcggac     2040

aattgaacgc ttaaaggagc agagggacag agatgagcga gagaagcaag aggaaattga     2100

taactacaaa aaagatctta aagacttgaa ggaaaaagtc agcctgttgc aaggcgacct     2160

ttcagagaaa gaggcttcac ttttggatct gaaagagcat gcttcttctc tggcatcctc     2220

aggactgaaa aaggactcac ggcttaagac actagagatt gctttggagc agaagaagga     2280

ggagtgtctg aaaatggaat cacaattgaa aaaggcacat gaggcagcat tggaagccag     2340

agccagtcca gagatgagtg accgaataca gcacttggag agagagatca ccaggtacaa     2400

agatgaatct agcaaggccc aggcagaagt tgatcgactc ttagaaatct tgaaggaggt     2460

ggaaaatgag aagaatgaca aagataagaa gatagctgag ttggaaaggc aagtgaaaga     2520

ccagaataag aaggtagcaa atctgaagca caaggaacag gtggaaaaaa agaagagtgc     2580

acaaatgtta gaggaggcgc gacgacggga ggacaatctc aacgacagct ctcagcagct     2640

acaggacagt ctccgtaaga aggatgacag gattgaagag ctggaagaag cactaagaga     2700

aagtgtacag ataactgcag agcgggaaat ggtgctagca caagaggaat cagccaggac     2760

caatgctgaa aaacaggtgg aggagttact gatggccatg gagaaggtaa agcaggaact     2820

agaatccatg aaagcaaagc tgtcctccac ccagcagtct ctggcagaaa aggaaactca     2880

cttgactaat cttcgggcag agagaaggaa acacttagag gaagttctgg agatgaagca     2940

agaagctctt ctggctgcca ttagtgaaaa agacgccaat atagctctct tggagctttc     3000

gtcctctaag aagaagaccc aagaggaagt ggctgccctg aagcgggaga aggatcgtct     3060

ggtacagcag cttaagcagc agacgcaaaa tcgaatgaag ctaatggccg acaactacga     3120

ggatgaccac ttcaaatcct cccattccaa tcaaacaaat cacaagccct ccccagacca     3180

gatcatccag cccctcttag aacttgacca aaatagaagt aaattaaagt tgtacattgg     3240

acacctgaca accctctgcc atgaccgaga ccccctgatc ctccgtggac tcactccacc     3300

agcttcctat aacttggacg atgaccaggc ggcttgggag aatgagctgc agaagatgac     3360

ccgggggcag cttcaggatg agttagagaa aggtgaacgg gacaatgcag aactgcagga     3420

gtttgccaac gccattcttc agcagatagc agaccattgt cccgacatcc tagagcaagt     3480

ggtcaacgcc ctggaagagt cctcttgacc ctgctttatg gggaagcctg aggtagtcaa     3540

cccaggagcc aagaaaagag aactacgagg aacaggtgcc cggaaccttc ttggcaccaa     3600

acactacaaa cttcatccca acttgctcac ttgaagaagt gtgattccag caccgtttct     3660

acatctgcca tcttactctg cctttctgct ttggatgtgg tctctacact aaccttcttg     3720

atgtccaggg tagataaagg gtcgaatctc tctgaagaac tgccacctgg tcatcagcag     3780

tggagaactg tgggagctgg tggctctgcc ctgacagaga gccatggagc agaggagcct     3840

ctcacctcct gtcctctgac atgagaatga aaccaggaat ggacttggag ttcaacaggc     3900

tgagaggatg cctccaatgg accagagagc tgagtgttct aatatcacaa taggtgcttt     3960

ctcctaaaag ggcaaaaaac aatctcaaaa agattagaaa aagagaaggg gggaagggaa     4020

gagaaaatcg actcttcttt ttactgtctc ttctgcttac tttccacatg agatgctttg     4080

taccggggag ctgtgagcag gcctcacgat ggcttgggag cactcgttct cccaaggtct     4140

gagtcttcat ccagccctgc ctgtctgtcg cagccttcct cactctgttc ctcggccagt     4200

taacaagaag atggtgtgag gtgttctcca ccagtctctc ctgtttgaga ctgttgacgt     4260

tatcatactg aggtgttaga tcaaatatct ctaattgaag aacatgtgag gttgaaagag     4320

caccagccag ggcaacatag cgtgaccctg tctctacaaa aaattaaaaa gagaacatac     4380

aaagttgaca tatgagaccc tgttgtcccc gcctgcagct ttgccccagt aacagatgcc     4440

cgttgctctt gggctggttt cccctgaaca cctccaagag gctgcctgcc ttgccagcac     4500

ccgtgtcctg agctcctgca gcccagtggc tgctgaagtt gtgatccctc actcaccctg     4560

ctagctttgc ccttgactcg tcttctctga acctcagcct cgtgcattgc ctggaacctt     4620

cttctagcat aaatgaaggt ttttcctcct acacacattc cttcctcggt tatttcattc     4680

agagaatatt tatgaaatgc ctactgtgtg caagtcatcc atccttgaaa aggccacttc     4740

tcagtgaggg agagatgtag tggattctgt gagacatacc tgctggagtt gaagcagtaa     4800

atagcatgtc cttcccctcc ccgatcttaa ggtgtgtttt ctagaaaagt tccctaatgg     4860

aattcatgag tttgggggtc tcagtcaccc gcttgcctgt aggattccat ttgatgattc     4920

tggatttttg ctgtttgtta ttgcccttag aggggctctg agtatctact tgtgggtggc     4980

catttcctga catctgcatg tacctcgtgg aattcagcca gcttcatgtt gcaaatcaga     5040

aagctgaccc caagactgca aatcaatgaa ggtattggca ttgttaagga cgtagcgtag     5100

acaacagcag tcataaataa ttaggcagga acttaaccca aatctagttc tttgaccacc     5160

tctaccacca gaacccagca gacactcaca tctcctgata agagttgctg gactcgatgt     5220

ttttgttttg cattttctcc tctccttccc cacttactca gagaatttaa agtctgtaga     5280

gtcagcacag ccccatcagt ccaggaactt cccaccacca gcccttgact gtcccattaa     5340

ctgacatggt cagatttcca gctcccccta ctccctgctg tgaaacaatc cctctccctg     5400

tgagaggaaa ctgtggagcg tttcttatcg aaggttaaat ggactctgct cataaacctc     5460

ttactgagat gcttcctgat agccaggctg gccagagagg ggtgcagggg ttagatagta     5520

agtggtggtc gtttgtggtc agttacctca attctgttca ttgcagtgcc cgtaaaccat     5580

gtagaaagct cccagcactg aaaggcagga gtgttagcat ctcgctttat ccaccataac     5640

gtaaagaact gcggtgtgat aacagccttc acggggccac ggtggaacca agacagcagg     5700

cgaggccatg cctaaacaag tggtctggca cgggcactgg ccagctgctc tctccaagca     5760

ggtggcccag atcccaccca cgtggacttt ctcatcaggt gcagcgcctg ccactctcag     5820

ccactgggtg tgtcactctc ctcttcatct cagcattctc catcacttcc cctccagaaa     5880

aacggatgga aggaagccct ctgtgacact gcttctgaga agaagcattt ccgggaccga     5940

tatcatctgt ctggtctctg tgaacagcaa ggaatcttct tgaccgttct tgggcactgg     6000

aggctggcta ggagttcagt aataaacgtg gccttcgtgc tgtagggcag agtggatgca     6060

gtttgtagct ttcagagtgt ctcattgagt ctagatcatt gaaccaacac ttaaccaaat     6120

gtcccactcc catcacacta ggacttgtca ttccatgccc ctctcctagt ggtcatggtt     6180

tcatatgggc atacaactgc tactgaagtt atatagcctt gaaaactcag tgcaggttgc     6240

ccttaatttt ccccaaaccc ctccatcggc aagtctagtt gccctttagc acctaaagat     6300

ctgcacccca aaccaatgtc accataaaga gggcacgaag aagagtgggt gtgatcccaa     6360

cggggttttg taactgaaga agcccagtgt gagcttctca tcttttcata tacctctaac     6420

ccccggtact cattgaatca ttgatgaggt atctcaattg agatttgcaa ggactttgat     6480

accatttgaa atggaaaaat tttgaacggg ctttaacatg tttaagaaat atggatgggg     6540

ccggccacag tggctcacgc ctgtaatccc agaactctgg aaggctgagg caggcggatc     6600

acctgagatc aggagttcga ggccagcctg gccaagatgg caaaaacccc gactctacta     6660

aaaatacaaa attagccagg cgtggtggcg tacgcctgta atcccagcta ctcaggaggc     6720

aggagaatcg cttgagcctg ggaggcagag gctgcggtga gccgagatcg tgtcactgca     6780

ctccagcctg ggtgacagag actccattta aaaaaaaaaa aaaaaaatat atatatatat     6840

atatatatat atatatggat gggaatcacc aaattcatct cagctctaac cttttaacct     6900

ttgtccttgc actttacaat ctaaagatct acctgtggct ctcagacttc ctcacacttg     6960

ggttttagaa ataacttgta aagcagactg gacccaaggc cgccttcagt gtcaagaagg     7020

gcattgtgac ttgcccctca atttctgtcc attgaagtct ggttttccat gaggaacttg     7080

cgggctcacc cacccccaga gtgagagaag aggaaggcga agtcatcaca gacacggtct     7140

tagccacctg ctgaactaat ccctccgcta ttgagggtca gggttgtgag gcaaccatca     7200

tgtgtcaccc caaaatataa atgtttctga gccgcccatc cactggcatt tggatttgct     7260

gccagagtcc tgttcctccc agaaccatcc cgccctcctg ttgaccatgt tacttgagtg     7320

taggcccggt gtcaagaccc tcagagtctt tgaggaaaga gccaagcaga gaagaccgct     7380

gcgtggagtg tgacaccaca tggcatttct caagcccagc ggaccctgtg tcagcaaata     7440

ccagtaattt aacatctgct cctggcctcc tcttcacctg cctgggttcg gaactgagga     7500

ggaaggatga gaagagactg caatgcagca ggcaccctct gcagagtgag gccgcccgtc     7560

catcactgcc agccctgggc tgctcaggag gggacgtgaa ccactcaaag gaatgtctta     7620

aagaggatct ggagtttccc ccatgcaaat tagggaagaa ttaggcaaga aaagacatac     7680

attacaggga aatccttctg aacaaaatgg ctgtcttcac ctactcttct tgcaagaaaa     7740

gacatacatt acagggaaat ccttctgaac aaaatggcta tcttcaccta ctcttcagca     7800

aaaaccgtct ccagactttt tagtgtcaaa aatgtaacca actgtctcct gattttttcc     7860

aatgtgtttg gcaagtgctg tggccctgtt gtaggtactt ctcctgactc ttgggggaga     7920

agtggtttta gggattgatt tgggggagcg ggtttttgtc ccatcccacc tcctctcttc     7980

tttctctgct tgtcgatatt gtctgtgtga ttcagagaat tggggcagtt acattgtgtc     8040

tgttgttgag attattaaaa gattaaaacg tagttgtaga aatgaaaaat taaacagctg     8100

tgttttaaaa atgcaaacca atatcttgtt aataaaggaa ttcaagctat ggggcagcca     8160

cactcccctc ctcccaggct ggcataggtg gccctgggct ggcggcttag gaagcatgga     8220

gcacacttag ggtagtgcct gcctgggcaa gagacacctg ccgagcaaaa ggaacgagaa     8280

tctggggctc agagcctcgc agttgtgcca ggattttcct atacatgttc aggacctctg     8340

ggtagaggtt tcacagtttg tgaccccata accaccctca cccgacgtgg gttctagctc     8400

agtgtgccta atactgcatg gtaacctggg cttgaccctg aagcccctgc ctggcaggcc     8460

acaggacctc tcctgcccac ttggtgctat ctcttccagt gaccacccag cacgggtgag     8520

cactggccag cctggagcct gcaatccagg tggaacagac tgtcctccat gtcagttcct     8580

tctggcttca ggccctcaat tatttccctt tgagcttttt tagaccctag atctcctagg     8640

cccaggctct ctcttgaccc cagagaagcc actgtcagga aaggaagtga accctactga     8700

agccagagaa ttcaccccgg ccaaagcagg ccctctgggt ccagcccctc attccacacc     8760

acgccagtat tgcatccatc tactgcagct acacatcctg agggcagcac cacccactct     8820

ggcctgctgg cccatcgcag gactagccca ggcacctgcc gggcattgca ggatatccag     8880

tggggcctgt gactgctccc tgatgcgtca gaagagaagt gttgcacttt agtggaggag     8940

ctgaggagca cctgccccct tgtagcttga gttccttttg gtaacagtag cagcctccat     9000

ggtggtgtct gggatgcacg tgcacccgct gccttcagct gtatgtgtgt gttcctgctg     9060

gagttgtgtt actgacagga taatgacatt acaaagaaat tgtgttatat tcaactttgc     9120

cttgataatt attgtaaaca ctttgttcat tttttctttt ttattcacaa actaaatcca     9180

ccaggaaatt ataaagttat tt                                              9202


<210> 4659
<211> 4751
<212> DNA
<213> Homo sapiens

<400> 4659
ggacgggggc ccggtgggcc cgcggaggaa agatactggg gagtgggagc cgcggggttc       60

agagcgatga ttcccccaca ggaggcatcc gctcgacggc gggagattga ggacaagctg      120

aagcaggagg aggagactct gtccttcatc cgagacagcc tggagaagag cgaccagctc      180

actaagaaca tggtgtctat cttatcatcc tttgagagcc gccttatgaa gctggagaac      240

tccatcatcc ctgtgcacaa gcagacggag aatctgcagc ggctgcagga gaatgttgag      300

aagacgctgt cctgcctgga ccatgtcatc agctactacc atgtggccag tgacactgag      360

aagatcatca gagagggccc cacaggtagg ctggaagagt acctgggaag catggccaag      420

attcagaagg cagtggagta tttccaggac aacagcccag acagcccgga actcaacaaa      480

gtgaaactgc tctttgagcg cgggaaggag gccctggagt ccgaatttcg cagcctgatg      540

acgcggcaca gtaaggtcgt ctcgcccgtg ctcatcttgg atctgatcag tggtgacgat      600

gatctggagg cccaggagga cgtgaccctg gagcacctgc ccgagagcgt gctccaggat      660

gtcattcgca tctcccgctg gctggtggaa tatggccgca accaagattt catgaacgtc      720

tactaccaga tacgctccag ccagctggac cgctccatca aaggactgaa ggagcatttc      780

cataagagca gttcttcctc tggggttccc tactcccctg ctatccccaa caagaggaaa      840

gacacaccta ccaagaagcc agtcaagcgg ccagggacga tccgtaaggc tcagaacctt      900

ctgaaacagt attcccagca tggtctagat gggaaaaagg ggggctctaa cctcattcct      960

ctggaaggga gagatgacat gctggacgtg gagaccgatg cctacatcca ctgcgtcagt     1020

gccttcgtca agctggcgca gagcgagtac cagctgctgg ccgacatcat ccccgagcac     1080

caccagaaga agaccttcga ctccctgata caggatgccc tggatgggct gatgcttgaa     1140

ggggagaaca tcgtgtctgc tgcccggaag gccattgtgc gacacgactt ctccacggtg     1200

ctcaccgtct tccccatcct gcgacacctc aagcagacca agcctgagtt tgaccaggtg     1260

ctccagggca cggctgccag cacaaagaac aagctgcctg gcctcatcac atccatggag     1320

accatcggtg ccaaagcgct ggaggacttc gcagacaaca tcaagaatga cccggacaag     1380

gagtacaaca tgccgaagga cggcaccgta cacgagctca ccagcaatgc catcctcttc     1440

ctgcagcagc ttttggactt ccaggagacg gcaggcgcca tgctggcctc ccaagagacc     1500

agctcttcgg ccaccagcta cagctctgag ttcagcaagc ggctgctaag cacctatatc     1560

tgtaaagtgc tgggcaacct gcagttgaac ttgctgagca agtccaaggt gtacgaggac     1620

ccagctctga gcgccatctt cctgcacaac aactacaatt acatcctcaa gtccctggag     1680

aagtctgaac tgatccagct ggtggcagtg acacagaaga ctgctgagcg ctcctaccgg     1740

gagcacattg agcagcagat ccagacctac cagcgcagct ggttaaaggt gactgattac     1800

atcgcagaga agaatctacc tgtgttccag ccgggagtca agctccggga caaggagcgg     1860

cagattatca aggagcgttt taagggcttc aatgatggcc tcgaagaact gtgcaaaatc     1920

cagaaggcct gggctattcc agacacagag cagagggaca ggattcgcca ggcccagaag     1980

accattgtca aggagaccta cggggccttt ctacagaagt ttggcagcgt gcccttcacc     2040

aagaacccgg agaagtacat caagtacggg gtggagcagg tgggcgacat gatcgatcgc     2100

cttttcgaca cctctgcctg agcctgctgc tagccctgcc tggttccacc agactggcgt     2160

gtcattggac agataaacca gtgttagctt gcctctgggc tgggtgagct tgaagtcctc     2220

tgggacagag acctgtctcc acgcctccgg gagctgtgtc cctgagcccc ctagtcctgg     2280

ctcctgcttt ttccccacag cccgtgttcc cagccgaacc agcactctcc cggaagcctg     2340

gggtccctcc acaccttggc ttttatgacc ctgatggctt ctgaaacagg aaaagagaga     2400

aggaagacag aggcctgtgc ccactgctgc tccatgtgta ccaagagcag cagggcagaa     2460

gggccctccc tccagcctag gtcagaggtg gggacagaga actcccctac agcccagaga     2520

tgtggcaggg ctcagagaag cagccagagc tcctggagga aaggcagtcg ggactgaccc     2580

cctctcttaa aacacattcc cgcccgccca caggcctgag gtctgggacc tttccctccc     2640

aggagtcccc taggtggctg ggggaggcag gctcactggc cattttccct agagtccagc     2700

acactgcagg aggcgttcgg aggaggagtt ccgccccacc ctctacagcc ttcctcaggc     2760

ccctgtctct ggcccccagc ctcagtgcct cttggcccag ggccaggcag tcgtggttgc     2820

agaaggagca attaggctgc ctgcctgtgg gctgggagac agggacaatg gggaaaagtt     2880

aaggagcaaa atgggggttg gaagcaaaaa atagggcccc acctatttag gacgagattg     2940

aagactgacc cttgaggcac acttgcactg gagatgggtt tatttcacgc tctgtgcttg     3000

tgtgctagcg gagggagagc tcagggtggc ttaatccaga ggccctgtca tggcccgccc     3060

ccagccatgg gaaagcaaac ttcatcctaa ggtgtgcagc ccaggccctg cccctttaca     3120

gtctaggccg cctgccatgg ggtgcagcct ctccaggggc tgcgtcagac ttgcacgctg     3180

cccacatcca gattcctgca aagacgaatt gggtgcacag caccccaacc acatacacga     3240

ggaagaagat gcggtcagca gtctcaggcc agcttctctg tgaccccttt actcctctgg     3300

agggctctgt ggggagagat acagggaaag gagctgttct tcaaggtccc ctcaacatga     3360

gcggaagagc gaaccccagg ggtcatcagc ctgtatcgct tcctttctta gattctcagc     3420

tgatgaaaat ttgggtctgg cccatttcag gccatcttca gttgaagaaa caccctctta     3480

ggctgtgcaa ggcatgggtt atcaggggat tgaggtcacc tgggacttca gggaggctca     3540

gcttgctccc tgccccagac ctgtttcttc taagggagga ggacatggtg gagaccaggg     3600

acaggagagc cagcagggtg gatgcaaggg gcctctaccc acacctggac ctccgtgccc     3660

tcaccccagc cctaggtgtg cacctaggcc tcattcctta ccccccagcc cctgcccacc     3720

ttcagcagga tgaggccctg ggttgccgtg ctctcgctgt tcccctctcg gggctgggct     3780

ggggccgctc ttggccccaa ggttgccccg ggccagcagc ccagccagca gcacagtctc     3840

tatggtgctg aggaagagca gcagcagcag gatggtgaag tagtaaactg ggggaggcag     3900

ggcacaggga gatgctcagg ggccagtccc tgtgtctctg gtgcccagcg agctgagcac     3960

cagtgggtga ccggggagaa acagggcaga ctgggtaagg gagcagggct tactgagcag     4020

tgggttgcag gaggaggagc tgggcagggc ctgcaccagg gaggagtgga ggacgaggta     4080

actcagcagc aatgtcacct tgtagcctat gcgctcaatg gcccggaggg gcagcaaccc     4140

cccgcacacg tcagccaaca gcagtgcctc tgcaggcacc aagagagcga tgatggactt     4200

gagcgccgtg ttcttcagcc tcagctggaa ggggaaaagt cagggccttc ccggcggggg     4260

ggaaggaggt gggcatcggg ggcatggggc ctggcctctg gccgtgcatc ctcactccca     4320

cccgcctcca gcagccctct gtcggcctcc tcccgacttg actcaccgtc acctggaagc     4380

agggcaccag ctgctggggt gggacttggg tcttcagatc ataaactacg tattccctct     4440

tgacactcac aatctcgttc accacgtggg cctggaactc taactccatc gctgaggggt     4500

gggaatgaga actatgaacc aggaaggaga gatcccagct gccaagtctg ggggtagcag     4560

actggagccc aggggtgatg gagacttttg atggcttttg gcagggacag acttggacac     4620

aaaaccgatc catagaaggg cttcccaaac cttgttttgc aacatcccaa attgtctcca     4680

gttgaaggaa ggcctttatc agattcatag atgagctttc attgtaaaaa taaatgtact     4740

ttgcaccact t                                                          4751


<210> 4660
<211> 697
<212> DNA
<213> Homo sapiens

<400> 4660
ccgtgcgccc aagctcgacc gcctgaaatc ggggaatcgg gcctctgccg gcgccctggc       60

agcggcgcgg ggcgtggctc cgggctggat tggtggcgcc tgggccccgc gagcgcctgc      120

gcagtggtca aggccgcgct cgcgccgagg ggctgcgaga gtgaccgcgg ctgctccagc      180

gctgacgccg agccatggcg gacgaggagc ttgaggcgct gaggagacag aggctggccg      240

agctgcaggc caaacacggg gatcctggtg atgcggccca acaggaagca aagcacaggg      300

aagcagaaat gagaaacagt atcttagccc aagttctgga tcagtcggcc cgggccaggt      360

taagtaactt agcacttgta aagcctgaaa aaactaaagc agtagagaat taccttatac      420

agatggcaag atatggacaa ctaagtgaga aggtatcaga acaaggttta atagaaatcc      480

ttaaaaaagt aagccaacaa acagaaaaga caacaacagt gaaattcaac agaagaaaag      540

taatggactc tgatgaagat gacgattatt gaactacaag tgctcacaga ctagaactta      600

acggaacaag tctaggacag aagttaagat ctgattattt actttgttta ttgtctatat      660

gccttttaaa aaaataaact tgttatgcaa aataaaa                               697


<210> 4661
<211> 3406
<212> DNA
<213> Homo sapiens

<400> 4661
gaaggcagcg gcaggtcggg agcaagatgg cgctgcggcc aggagctggt tctggtggcg       60

gcggggccgc gggagctggc gcggggtccg ccgggggagg cggcttcatg tttcctgttg      120

caggtgggat aagaccccct caagcaggcc tgatgccgat gcagcaacaa ggatttccta      180

tggtctctgt catgcagcct aatatgcaag gcattatggg aatgaattac agctctcaga      240

tgtcccaagg acctattgct atgcaggcag gaataccaat gggaccaatg ccagcagcgg      300

gaatgcctta cctaggacaa gcacccttcc tgggcatgcg tcctccaggc ccacagtaca      360

ctccagacat gcagaagcag tttgccgaag agcagcagaa acgatttgaa cagcagcaaa      420

aactcttaga agaagaaaga aaaagacgcc agtttgaaga gcagaagcaa aagctcagac      480

ttttgagcag tgtgaaaccc aagacaggag agaagagtag agatgatgct ttggaagcca      540

taaaaggaaa tttagatggg ttttccagag atgcaaaaat gcaccctact ccagcatcgc      600

accccaagaa accaggtgtg ggagtatttc cctcacagga tcctgctcag cccagaatgc      660

ctccttggat ttacaatgag agtttggttc cagatgccta taagaaaatc ttagaaacca      720

caatgactcc aactggaata gatactgcca aactgtatcc cattctgatg tcatctgggc      780

ttcccaggga aactcttgga cagatatggg ccttagctaa tcgaactaca cctggcaaac      840

ttacaaaaga agaactttat accgttctag ccatgatagc ggtaacacag gtagtaaagc      900

cagaagaaga tgacttccag gattttcaag atgcttctaa gtcaggatcc cttgatgact      960

cattcagtga tttccaagag ttgcctgctt cttcaaaaac aagtaactcc cagcatggaa     1020

acagtgcccc ttctttgttg atgccacttc ctggaactaa agcattgcct tcaatggaca     1080

aatatgctgt gtttaaagga attgcagctg acaagtcctc tgaaaatact gttccacctg     1140

gagatcctgg tgataaatat agtgctttca gagaacttga acagacagca gagaataaac     1200

ctttaggaga aagctttgca gaattcagat ctgcaggaac tgatgatggt ttcaccgatt     1260

ttaaaacagc cgatagtgta tcaccactag agccaccaac aaaagacaaa acttttccac     1320

catccttccc ctcaggaact atacaacaga aacaacaaac acaagtgaaa aaccctctga     1380

acttagcaga cctagatatg ttttcctcag ttaattgcag cagcgagaaa ccattgtctt     1440

tttcagctgt gtttagcaca tcaaaatcag tttctacacc acagtcaaca ggttctgctg     1500

ctactatgac agcattggca gcaacaaaaa cttctagttt ggctgatgat tttggagaat     1560

tcagcctttt tggggaatat tctggtctag cacctgttgg ggagcaggat gactttgcag     1620

attttatggc tttcagtaat agctctattt catctgagca aaagccggat gacaaatatg     1680

atgcccttaa agaggaagcc agtcctgttc ctctaaccag caacgtgggc agcacagtga     1740

agggtggaca aaactcgact gctgcgtcta ccaagtacga tgtcttcaga caactttctc     1800

tggaagggtc tggactaggt gttgaagacc tgaaagataa cactccttca ggaaaaagtg     1860

atgatgattt tgctgacttc cactccagta aattttcttc cataaactcg gacaaatccc     1920

tgggagagaa agcagtggct ttcagacaca ccaaagaaga ctctgcatca gtgaagtcct     1980

tagatctccc ttccattggt ggcagcagtg ttggcaagga ggactctgaa gatgcactct     2040

ctgttcagtt tgacatgaaa ttggctgatg tgggaggaga tcttaagcat gtcatgtctg     2100

atagctcttt ggatttacca acagttagtg gccagcatcc tcctgctgca gcaggaagtg     2160

gatccccctc agccacctca attcttcaaa agaaagagac ttcatttggc agttctgaaa     2220

acatcaccat gacatctctc tccaaagtaa cgacctttgt aagtgaagat gctcttccag     2280

agaccacctt cccagctctt gccagtttta aagacacgat tcctcagacc agtgagcaaa     2340

aggaatatga aaacagagac tataaagatt tcacaaaaca ggacctgcct acggctgaac     2400

ggagccagga ggccacgtgt cccagcccag cgtccagtgg tgcctctcaa gaaaccccga     2460

acgaatgttc ggatgacttt ggagagtttc aaagtgaaaa gcccaaaatc agcaaatttg     2520

acttcttagt agccacttca caaagcaaaa tgaaatccag tgaagaaatg atcaaaagtg     2580

agctggcaac ctttgacctt tctgttcaag gatcacacaa gaggagtttg agccttggtg     2640

ataaagaaat aagccgttct tctccttctc cagctttgga gcagcctttc agagaccgtt     2700

ccaatactct gaatgagaag cccgccctgc ccgtcatccg agacaagtac aaagacctga     2760

cgggagaggt ggaggaaaat gagagatatg catatgaatg gcagagatgc ctggggagtg     2820

ccctgaatgt cattaagaag gcaaatgata ccttaaatgg aatcagtagt agttctgttt     2880

gcacagaagt aattcagtca gctcaaggca tggaatattt attaggtgtt gttgaagtgt     2940

acagggtaac caagcgtgtg gagctgggga taaaagccac tgcagtgtgc agtgagaaac     3000

tccagcagtt gctgaaggac atcgataaag tatggaataa cctaatcggc ttcatgtcac     3060

tcgccacact cacaccagat gaaaactcgc tggatttttc ctcctgtatg ttacggcctg     3120

ggattaaaaa tgctcaggag cttgcctgtg gagtgtgcct cttgaatgtg gactcgagga     3180

gccggaaaga agagaagcct gcagaagaac atcctaaaaa agcattcaac tcagaaacag     3240

acagtttcaa gctggcctat ggagggcacc agtatcacgc cagctgtgcc aacttctgga     3300

tcaactgtgt cgaaccaaag cctcctggcc tcgtcctgcc tgacctgctc tgaacaactc     3360

ctctgtgaag cattgacttt tttttttctg tgacacccca cggggt                    3406


<210> 4662
<211> 2315
<212> DNA
<213> Homo sapiens

<400> 4662
caaatttgcg cgggttggag cctggcgtag tcatggccgc cttccgcgac atagaggagg       60

tgagccaggg gctgctcagc ctgctgggcg ccaaccgcgc ggaggcgcag cagcgacggc      120

tgctggggcg ccacgagcag gtggtggagc ggctgctgga aacgcaagac ggtgccgaga      180

agcagctgcg agagatcctc accatggaga aggaagtggc ccagagcctt ctcaatgcga      240

aggagcaggt gcaccaggga ggcgtggagc tgcagcagct ggaagctggg cttcaggagg      300

ctggggagga ggacacccgt ctgaaggcca gcctccttca gctcaccaga gagctggaag      360

agctcaagga gattgaggcg gatctggagc gacaggagaa ggaggtcgac gaggacacga      420

cagtcacaat cccctcggcc gtgtacgtgg ctcaacttta ccaccaagtt agtaaaattg      480

agtgggatta tgagtgtgag ccagggatgg tcaaaggcat ccatcatggc cccagtgtgg      540

cccagcccat ccacctggac agcacccagc tctccaggaa attcatcagc gactacctct      600

ggagtctggt ggacaccgag tggtagccag gagcctcgtg gctgcgtctt gcacccagcg      660

ggcatctgcc gtggtcagat ccatttcaaa tgaaatgtgg ggacatagat cttttttttt      720

ttttttttga gacagagttt cactcttgtt gtccagtctg gagtgcaatg gcacaatctc      780

agctcacagc aacctctgcc tcctgggttc aagcgattct cctgcctcag cctccaaagt      840

agctgggatt acaggcatgc gccaccacac ccagctaatt ttttgtattt ggtagagatg      900

gagtttcacc atggtggtca ggctggtctt gaactcctga cctcaggtga tccacccgcc      960

cgccttggcc tcccaaagtg ctaggattcc aggcgtgagc catcgtgccc agctagacgt     1020

cttccttttt tttttttttt tgagacggag tctcactctg tcgcccaggc tggagtgcag     1080

tggtgcgatc tcagctcact gcaagctccg cctcctcccg ggttcacgcc attctcctgc     1140

ctcagcctcc tgagtagctg ggactacagg cacctgccac catgcgcagc taattttttg     1200

tatttttagt agagacgggg tttcaccatg ttagacagga tggtctccat ctcctgagtt     1260

tgtgatctgc ccgccttggc ctcccaaagt gctgggatta caggtgtgag tcaccgcgcc     1320

tggccttttt tttttttttt tttactggat ttctttttct cctgattttc ggcctcagct     1380

cctagagtgg cctcagctag gtaaccaacg ggagtcgact tatctatgcc aggcctgcag     1440

tttcacatct gtgacgggat gggacaaatg acaccgtggt attcgatgac agctcccagg     1500

tacttcaagg ttggccctta ctcattcagg gggtatgttt gagtgccacg gtgtgcccag     1560

actctgctag gcaccagaga gacaagatac gagtgacatg gttctcctcc cactgctgac     1620

ggaggaatta acacaaaagc agacaacact ctagaactgg agagaggtcc agattgcgac     1680

aggagccaca ccagagtgtg caggcttcat ggaggacaga agcgactttt gtgccgggac     1740

ttaaaaagat aaggaggcca ggtgtggtgg ctcatgcctg caatcccagc actgtagaag     1800

gcagaggccg gcagatcact tgagcccagg agttggagac cagactgggg aacatggcaa     1860

gaccccatct ctacaaaaaa attaaaaaat ttggcctggt gtggtggctc atgcctgtga     1920

tcctagcact ttgggagtta aaatacaaca cttcccagct gcccttatag ttaaggtctg     1980

gccagtgaaa tgtatgtgga aatgttacat gacacttcta gaaggattct taaaagacaa     2040

atacaccctt tcttccccct tcctatttcc tggaatgtgg gtgtgatggc tggagccctg     2100

gcagccatac tgccacgtgt acagacgagt gccgtccttt agggatgaca ggagcctggt     2160

tccctgatga tggcagagcc agatatcagc acaaacttat ttaaatggga gagagaaggg     2220

gagaaccaat ctcaacttct accttgtgta agctgctggt tttgggggtt ttctatgaca     2280

gataccaaaa taaaccctaa ctgaacatgt actcc                                2315


<210> 4663
<211> 1005
<212> DNA
<213> Homo sapiens

<400> 4663
tttccggtgt cggggcacag ttgaagaagc gaccgaggga ctgggagtcg ttagtgagga       60

tgacgcggca tggcaagaac tgcaccgcag gggccgtcta cacctaccac gagaagaaga      120

aggacacagc ggcctcgggc tatgggaccc agaacattcg actgagccgg gatgccgtga      180

aggacttcga ctgctgttgt ctctccctgc agccttgcca cgatcctgtt gtcaccccag      240

atggctacct gtatgagcgt gaggccatcc tggagtacat tctgcaccag aagaaggaga      300

ttgcccggca gatgaaggcc tacgagaagc agcggggcac ccggcgcgag gagcagaagg      360

agcttcagcg ggcggcctcg caggaccatg tgcggggctt cctggagaag gagtcggcta      420

tcgtgagccg gcccctcaac cctttcacag ccaaggccct ctcgggcacc agcccagatg      480

atgtccaacc tgggcccagt gtgggtcctc caagtaagga caaggacaaa gtgctgccca      540

gcttctggat cccgtcgctg acgcccgaag ccaaggccac caagctggag aagccgtccc      600

gcacggtgac ctgccccatg tcagggaagc ccctgcgcat gtcggacctg acgcccgtgc      660

acttcacacc gctagacagc tccgtggacc gcgtggggct catcacccgc agcgagcgct      720

acgtgtgtgc cgtgacccgc gacagcctga gcaacgccac cccctgcgct gtgctgcggc      780

cctctggggc tgtggtcacc ctcgaatgcg tggagaagct gattcggaag gacatggtgg      840

accctgtgac tggagacaaa ctcacagacc gcgacatcat cgtgctgcag cggggcggta      900

ccggcttcgc gggctccgga gtgaagctgc aagcggagaa atcacggccg gtgatgcagg      960

cctgagtgtg tgcgggagac caaataaacc ggcttgggtg cgcaa                     1005


<210> 4664
<211> 1470
<212> DNA
<213> Homo sapiens

<400> 4664
tttccaagtt ctttctagcc tcaaccagtt tctgtctctg cttgttctgc agcccgctga       60

actacatttc ccaggaggcg tcggggctgc gccgtacaac ttccggctgt aaagatggcg      120

gcttcctagt gagtcggcgg ctgatttaga aggaggttca ggctacggtg agccgaagcc      180

acacaggagc catggaagtg gcagagccca gcagccccac tgaagaggag gaggaggaag      240

aggagcactc ggcagagcct cggccccgca ctcgctccaa tcctgaaggg gctgaggacc      300

gggcagtagg ggcacaggcc agcgtgggca gccgcagcga gggtgagggt gaggccgcca      360

gtgctgatga tgggagcctc aacacttcag gagccggccc taagtcctgg caggtgcccc      420

cgccagcccc tgaggtccaa attcggacac caagggtcaa ctgtccagag aaagtgatta      480

tctgcctgga cctgtcagag gaaatgtcac tgccaaagct ggagtcgttc aacggctcca      540

aaaccaacgc cctcaatgtc tcccagaaga tgattgagat gttcgtgcgg acaaaacaca      600

agatcgacaa aagccacgag tttgcactgg tggtggtgaa cgatgacacg gcctggctgt      660

ctggcctgac ctccgacccc cgcgagctct gtagctgcct ctatgatctg gagacggcct      720

cctgttccac cttcaatctg gaaggacttt tcagcctcat ccagcagaaa actgagcttc      780

cggtcacaga gaacgtgcag acgattcccc cgccatatgt ggtccgcacc atccttgtct      840

acagccgtcc accttgccag ccccagttct ccttgacgga gcccatgaag aaaatgttcc      900

agtgcccata tttcttcttt gacgttgttt acatccacaa tggcactgag gagaaggagg      960

aggagatgag ttggaaggat atgtttgcct tcatgggcag cctggatacc aagggtacca     1020

gctacaagta tgaggtggca ctggctgggc cagccctgga gttgcacaac tgcatggcga     1080

aactgttggc ccaccccctg cagcggcctt gccagagcca tgcttcctac agcctgctgg     1140

aggaggagga tgaagccatt gaggttgagg ccactgtctg aaccatccct gtacatctgc     1200

accttcttgt gcaaggaagt ccttggccta aagccttggt tctcaaactg ggttccttgg     1260

gacctccggg gtgggggggt tccaggaggc acgtagggta ccttgcaggg tcctaggagg     1320

gaaacccagg attccaggag ggatcccagg aactgtgggc acccattttc tgtgtctccc     1380

agcccatttc cactcctagt ttgtcatgga taatttttgt tcttccctgt gtgatttttg     1440

ccatcaaaat aaaaatttga gactcgttaa                                      1470


<210> 4665
<211> 3184
<212> DNA
<213> Homo sapiens

<400> 4665
tgttgatatc aatatggcgg ttgtcagcca gacaaagaca gtcagtctga tgtgattgag       60

acaagggagg tttttcaggg ggagactggg agataggggc ctcccctccc ccttctcctc      120

ttcctgcgcc ggcctcaacc cctccccagt cccctcccga cgggcgcccc acgcggaaga      180

cacccctccc cctcccgcct tccctcctcc ctatctcagc ccttcgtact gggacgttgg      240

ggagggggct gtgccgggcg gagagaactc agcgaggatt ctgagaatgg tagataacgc      300

agatcatctc tggaaaggat attgatccgc ctcatgtaaa gtatgcttag ttcctttcca      360

gtggttttgc tggaaaccat gtctcattat acagatgaac ccagatttac catagagcag      420

atagatctgc ttcagcgact tcggcgtact ggaatgacta aacatgaaat tctccatgcc      480

ttggaaactt tggaccgtct tgatcaagag catagtgaca agtttggaag aaggtccagc      540

tatggaggaa gttcatatgg gaatagtact aacaatgtcc cagcatcttc ctctacagct      600

acagcttcca cacagacgca gcattcggga atgtccccgt cacctagcaa cagttatgat      660

acttccccac agccttgcac taccaatcaa aatgggaggg agaataatga gcgattatct      720

acatccaatg gaaagatgtc accaactcgc taccatgcaa acagcatggg tcagaggtca      780

tacagttttg aagcctcaga agaggaccta gatgtagatg ataaagtgga agaattaatg      840

aggagggaca gcagtgtgat aaaagaggaa atcaaagcct ttcttgccaa tcggaggatt      900

tcccaagcag ttgttgcaca ggtaacaggt atcagtcaga gccggatctc tcattggctg      960

ttgcagcagg gatcagacct gagtgaacag aagaaaagag cattttaccg atggtatcaa     1020

cttgagaaga caaaccctgg cgctacacta agtatgagac cagcccccat tccaatagag     1080

gaccctgaat ggagacaaac gcctccccca gtctctgcca catctggtac tttccgactg     1140

cgacgaggga gtcgatttac ctggagaaag gagtgcctgg ctgttatgga aagttacttc     1200

aatgagaatc aatacccaga tgaagcaaag agggaagaaa ttgcaaacgc ttgcaatgca     1260

gttatacaga agccaggcaa aaagctgtca gatctggaaa gagttacctc cctgaaagta     1320

tataattggt ttgctaacag aaggaaggag atcaagagga gagccaatat tgaagcagca     1380

atcctggaga gtcatgggat agatgtgcag agtccaggag gccactcaaa cagtgatgat     1440

gtcgacggga atgactactc tgagcaggat gacagtacga gccatagtga ccaccaagac     1500

cccatctcat tagctgtgga aatggcagca gtcaaccaca ctatcttggc attggcccga     1560

caaggagcca acgaaatcaa gacagaggcc ctggatgatg actgatcagg gaggttaaac     1620

atgacaagtt aacttagttt agacgtagca ccttagcaga ctttcctcgg tccttaacat     1680

gtgttcttac agtataactt gcagtttctt gtatgtcagg tagctgttag ggtcttgttc     1740

tgtgaagatg gcatggtgcc ctcagccttt gcatatactc tctcagtatt aactcccagt     1800

aaataataac caaccaacca accaaacttc cctctcccag cccccgaggc tagaaaatct     1860

tgctgctccg tcttagcatt ccaagaaagt gcttccaggt atttagatag ccctcagttc     1920

tcaaatatta gactacgtgt aaaatcttgg gtacctttag attcttgtaa cactagtctg     1980

tactcccttt tccttcccca agactgatag gatgcaagct gaggtcgtgg cacaggaatg     2040

acagacacca tttggggagt atccacagag tcaaaggaac actagaatcc ccacctcagc     2100

gtgaggataa ttgatttcca gctgcaataa gccgtgcctc attatagcca cactgtggct     2160

agattatact tctttgggtg ctgtgctaag aatgtcaatg gaaaaagccg atctcagatt     2220

ttgtttgaag ttaacatgcc tgacacagac atcctttcct ctcacaagct gtgtgactta     2280

gtagataaaa tactgccttc tgcctttggg accatgatta aaaacaaaga caaaaaccaa     2340

aagtcattaa aaaaaaaaaa aaaaaaaacc cagcttgaga gcattggaaa aaaaaaatat     2400

gagctgaatg tctaatggat gctaagtcca gttttcagaa ccactgtaca ttccacggca     2460

cagttagcag tgcctgcctg gaaaagtttt ggaggtcatc gtggaagttg ctttgcctcc     2520

tgtcagtgtc ccctttccct gctaccaaaa aagtctttca aggatggagc taaggtcaaa     2580

aatgagtgaa aaaacttgca gtgtttgtat ccattaaacg gaagccccct cactctgaga     2640

ggtcactaga ggacttcata gtggggttgt gctgcttatc acagatgcag acacttgccc     2700

agataggagc agagaaaagc aggggacgtt tcctactcac attgtggctg tatgagaaca     2760

cgatgggact gctttgctgt tctctttact ctgtccttgg agaggtgtga aaagctgtat     2820

tgctacaggc aatttattta ataattggaa gccatattga taatggatgt ggtaatattt     2880

gtaaagttta atctacttta agcggcagta actaatggaa tttttttcct tgatcacata     2940

tgtagcactt ttgttacttt ttaaagatat ttatatttga taaatctttt tttcattttg     3000

agaactcaaa ataccaaaca gtgaacttgc attctaaagt caccctgtga tcaccttgtc     3060

atctagtagc aaaatgatga actattcatg catcaaagaa aattacatct gctggccttg     3120

tatgaaaatg atctcttggc atcccgatta aatgacacac tgtcactgtg ggtaagagga     3180

aaga                                                                  3184


<210> 4666
<211> 4082
<212> DNA
<213> Homo sapiens

<400> 4666
aatatggcgg ttgtcagcca gacaaagaca gtcagtctga tgtgattgag acaagggagg       60

tttttcaggg ggagactggg agataggggc ctcccctccc ccttctcctc ttcctgcgcc      120

ggcctcaacc cctccccagt cccctcccga cgggcgcccc acgcggaaga cacccctccc      180

cctcccgcct tccctcctcc ctatctcagc ccttcgtact gggacgttgg ggagggggct      240

gtgccgggcg gagagaactc agcgaggatt ctgaggtgag tcgagcggtt ttgaagccgg      300

actacctcaa gtctctttcc tcacttcttt ctcttcactt aaaacaattt ttttggaggg      360

gttttgggga ggaagtgagc ggacgctggg gatgggtctc gtaagcggcc ggattgagag      420

gagggaggaa gcagggggct tccgagtggg tgacccagac gcgggctgtg gggtggggca      480

gttcgtgggg tccggtcctg gaaaggcgtc gactgccccc caactcttct ggtttcctct      540

acgatgagcg gaaggtttga atcctggagg tggggtctcc ggtgtggagt tctggaaact      600

gtgaggtgat ttgcagctgg tggaatggaa cagtgaagaa gcattggaat ggtagataac      660

gcagatcatc tctggaaagg atattgatcc gcctcatgta aagtatgctt agttcctttc      720

cagtggtttt gctggaaacc atgtctcatt atacagatga acccagattt accatagagc      780

agatagatct gcttcagcga cttcggcgta ctggaatgac taaacatgaa attctccatg      840

ccttggaaac tttggaccgt cttgatcaag agcatagtga caagtttgga agaaggtcca      900

gctatggagg aagttcatat gggaatagta ctaacaatgt cccagcatct tcctctacag      960

ctacagcttc cacacagacg cagcattcgg gaatgtcccc gtcacctagc aacagttatg     1020

atacttcccc acagccttgc actaccaatc aaaatgggag ggagaataat gagcgattat     1080

ctacatccaa tggaaagatg tcaccaactc gctaccatgc aaacagcatg ggtcagaggt     1140

catacagttt tgaagcctca gaagaggacc tagatgtaga tgataaagtg gaagaattaa     1200

tgaggaggga cagcagtgtg ataaaagagg aaatcaaagc ctttcttgcc aatcggagga     1260

tttcccaagc agttgttgca caggtaacag gtatcagtca gagccggatc tctcattggc     1320

tgttgcagca gggatcagac ctgagtgaac agaagaaaag agcattttac cgatggtatc     1380

aacttgagaa gacaaaccct ggcgctacac taagtatgag accagccccc attccaatag     1440

aggaccctga atggagacaa acgcctcccc cagtctctgc cacatctggt actttccgac     1500

tgcgacgagg gagtcgattt acctggagaa aggagtgcct ggctgttatg gaaagttact     1560

tcaatgagaa tcaataccca gatgaagcaa agagggaaga aattgcaaac gcttgcaatg     1620

cagttataca gaagccaggc aaaaagctgt cagatctgga aagagttacc tccctgaaag     1680

tatataattg gtttgctaac agaaggaagg agatcaagag gagagccaat attgaagcag     1740

caatcctgga gagtcatggg atagatgtgc agagtccagg aggccactca aacagtgatg     1800

atgtcgacgg gaatgactac tctgagcagg atgacagtac gagccatagt gaccaccaag     1860

accccatctc attagctgtg gaaatggcag cagtcaacca cactatcttg gcattggccc     1920

gacaaggagc caacgaaatc aagacagagg ccctggatga tgactgatca gggaggttaa     1980

acatgacaag ttaacttagt ttagacgtag caccttagca gactttcctc ggtccttaac     2040

atgtgttctt acagtataac ttgcagtttc ttgtatgtca ggtagctgtt agggtcttgt     2100

tctgtgaaga tggcatggtg ccctcagcct ttgcatatac tctctcagta ttaactccca     2160

gtaaataata accaaccaac caaccaaact tccctctccc agcccccgag gctagaaaat     2220

cttgctgctc cgtcttagca ttccaagaaa gtgcttccag gtatttagat agccctcagt     2280

tctcaaatat tagactacgt gtaaaatctt gggtaccttt agattcttgt aacactagtc     2340

tgtactccct tttccttccc caagactgat aggatgcaag ctgaggtcgt ggcacaggaa     2400

tgacagacac catttgggga gtatccacag agtcaaagga acactagaat ccccacctca     2460

gcgtgaggat aattgatttc cagctgcaat aagccgtgcc tcattatagc cacactgtgg     2520

ctagattata cttctttggg tgctgtgcta agaatgtcaa tggaaaaagc cgatctcaga     2580

ttttgtttga agttaacatg cctgacacag acatcctttc ctctcacaag ctgtgtgact     2640

tagtagataa aatactgcct tctgcctttg ggaccatgat taaaaacaaa gacaaaaacc     2700

aaaagtcatt aaaaaaaaaa aaaaaaaaaa cccagcttga gagcattgga aaaaaaaaat     2760

atgagctgaa tgtctaatgg atgctaagtc cagttttcag aaccactgta cattccacgg     2820

cacagttagc agtgcctgcc tggaaaagtt ttggaggtca tcgtggaagt tgctttgcct     2880

cctgtcagtg tcccctttcc ctgctaccaa aaaagtcttt caaggatgga gctaaggtca     2940

aaaatgagtg aaaaaacttg cagtgtttgt atccattaaa cggaagcccc ctcactctga     3000

gaggtcacta gaggacttca tagtggggtt gtgctgctta tcacagatgc agacacttgc     3060

ccagatagga gcagagaaaa gcaggggacg tttcctactc acattgtggc tgtatgagaa     3120

cacgatggga ctgctttgct gttctcttta ctctgtcctt ggagaggtgt gaaaagctgt     3180

attgctacag gcaatttatt taataattgg aagccatatt gataatggat gtggtaatat     3240

ttgtaaagtt taatctactt taagcggcag taactaatgg aatttttttc cttgatcaca     3300

tatgtagcac ttttgttact ttttaaagat atttatattt gataaatctt tttttcattt     3360

tgagaactca aaataccaaa cagtgaactt gcattctaaa gtcaccctgt gatcaccttg     3420

tcatctagta gcaaaatgat gaactattca tgcatcaaag aaaattacat ctgctggcct     3480

tgtatgaaaa tgatctcttg gcatcccgat taaatgacac actgtcactg tgggtaagag     3540

gaaagagcct tcaatgtagc agcacagggt gcgcctgaaa gaggcacaac tgctgtggat     3600

tttctgcctc gctccatctc tcctatgtat aatgaagcct tgtttaaagg ggcatgtggg     3660

gctggatgtt aagcacggct tctttttgtc cgttacctga aaacaatttc taagataaaa     3720

ggaaggtgcc atttccttac ctcttcaccc atcctcctcc accaaatgta ttcaacttaa     3780

aactgtgaga gagagagact gaatgacctt cctcagtttt ccctttctca ttcaggagat     3840

actgaatatc cgccagtttg tagttggttt ccttccactt aaggcacacg ctgactgcat     3900

catttcctta tctgttaatc ctgcttatgt gagtgtgagg aaagtctttg agagggcatg     3960

aaagtgccac cttatatatg tctgtgactt taaagagcta tatgcagggc ctggtcccac     4020

ttttgtccat ggatttcagg gggaaaaaat atatgtactt ttttcagctt ccaagcattg     4080

aa                                                                    4082


<210> 4667
<211> 1257
<212> DNA
<213> Homo sapiens

<400> 4667
tgttgatatc aatatggcgg ttgtcagcca gacaaagaca gtcagtctga tgtgattgag       60

acaagggagg tttttcaggg ggagactggg agataggggc ctcccctccc ccttctcctc      120

ttcctgcgcc ggcctcaacc cctccccagt cccctcccga cgggcgcccc acgcggaaga      180

cacccctccc cctcccgcct tccctcctcc ctatctcagc ccttcgtact gggacgttgg      240

ggagggggct gtgccgggcg gagagaactc agcgaggatt ctgagaatgg tagataacgc      300

agatcatctc tggaaaggat attgatccgc ctcatgtaaa gtatgcttag ttcctttcca      360

gtggttttgc tggaaaccat gtctcattat acagatgaac ccagatttac catagagcag      420

atagatctgc ttcagcgact tcggcgtact ggaatgacta aacatgaaat tctccatgcc      480

ttggaaactt tggaccgtct tgatcaagag catagtgaca agtttggaag aaggtccagc      540

tatggaggaa gttcatatgg gaatagtact aacaatgtcc cagcatcttc ctctacagct      600

acagcttcca cacagacgca gcattcggga atgtccccgt cacctagcaa cagttatgat      660

acttccccac agccttgcac taccaatcaa aatgggaggg agaataatga gcgattatct      720

acatccaatg gaaagatgtc accaactcgc taccatgcaa acagcatggg tcagaggtca      780

tacagttttg aagcctcaga agaggaccta gatgtagatg ataaagtgga agaattaatg      840

aggagggaca gcagtgtgat aaaagaggaa atcaaagcct ttcttgccaa tcggaggatt      900

tcccaagcag ttgttgcaca ggtaacaggt atcagtcaga gccggatctc tcattggctg      960

ttgcagcagg gatcagacct gagtgaacag aagaaaagag cattttaccg atggtatcaa     1020

cttgagaaga caaaccctgg cgctacacta agtatgagac cagcccccat tccaatagag     1080

gaccctgaat ggagacaaac gcctccccca gtctctgcca catctggtac tttccgactg     1140

cgacgaggga gtcgatttac ctggagaaag gagtgcctgg ctgttatgga aaggaacact     1200

tggtcccctg agagaaggat ggaagaaaat aaatggaagt tgctttctgc agggtag        1257


<210> 4668
<211> 3244
<212> DNA
<213> Homo sapiens

<400> 4668
tgttgatatc aatatggcgg ttgtcagcca gacaaagaca gtcagtctga tgtgattgag       60

acaagggagg tttttcaggg ggagactggg agataggggc ctcccctccc ccttctcctc      120

ttcctgcgcc ggcctcaacc cctccccagt cccctcccga cgggcgcccc acgcggaaga      180

cacccctccc cctcccgcct tccctcctcc ctatctcagc ccttcgtact gggacgttgg      240

ggagggggct gtgccgggcg gagagaactc agcgaggatt ctgagaatgg tagataacgc      300

agatcatctc tggaaaggat attgatccgc ctcatgtaaa gtatgcttag ttcctttcca      360

gtggttttgc tggaaaccat gtctcattat acagatgaac ccagatttac catagagcag      420

atagatctgc ttcagcgact tcggcgtact ggaatgacta aacatgaaat tctccatgcc      480

ttggaaactt tggaccgtct tgatcaagag catagtgaca agtttggaag aaggtccagc      540

tatggaggaa gttcatatgg gaatagtact aacaatgtcc cagcatcttc ctctacagct      600

acagcttcca cacagacgca gcattcggga atgtccccgt cacctagcaa cagttatgat      660

acttccccac agccttgcac taccaatcaa aatgggaggg agaataatga gcgattatct      720

acatccaatg gaaagatgtc accaactcgc taccatgcaa acagcatggg tcagaggtca      780

tacagttttg aagcctcaga agaggaccta gatgtagatg ataaagtgga agaattaatg      840

aggagggaca gcagtgtgat aaaagaggaa atcaaagcct ttcttgccaa tcggaggatt      900

tcccaagcag ttgttgcaca ggtaacaggt atcagtcaga gccggatctc tcattggctg      960

ttgcagcagg gatcagacct gagtgaacag aagaaaagag cattttaccg atggtatcaa     1020

cttgagaaga caaaccctgg cgctacacta agtatgagac cagcccccat tccaatagag     1080

gaccctgaat ggagacaaac gcctccccca gtctctgcca catctggtac tttccgactg     1140

cgacgaggga gtcgatttac ctggagaaag gagtgcctgg ctgttatgga aagttacttc     1200

aatgagaatc aatacccaga tgaagcaaag agggaagaaa ttgcaaacgc ttgcaatgca     1260

gttatacaga agccaggcaa aaagctgtca gatctggaaa gagttacctc cctgaaagta     1320

tataattggt ttgctaacag aaggaaggag atcaagagga gagccaatat tgcagcaatc     1380

ctggagagtc atgggataga tgtgcagagt ccaggaggcc actcaaacag tgatgatgtc     1440

gacgggaatg actactctga gcaggatact tggcaagtac gcaatgggga ggaggaggag     1500

ggaagaagtt cagagggagg cagagaagca gagaaggatg acagtacgag ccatagtgac     1560

caccaagacc ccatctcatt agctgtggaa atggcagcag tcaaccacac tatcttggca     1620

ttggcccgac aaggagccaa cgaaatcaag acagaggccc tggatgatga ctgatcaggg     1680

aggttaaaca tgacaagtta acttagttta gacgtagcac cttagcagac tttcctcggt     1740

ccttaacatg tgttcttaca gtataacttg cagtttcttg tatgtcaggt agctgttagg     1800

gtcttgttct gtgaagatgg catggtgccc tcagcctttg catatactct ctcagtatta     1860

actcccagta aataataacc aaccaaccaa ccaaacttcc ctctcccagc ccccgaggct     1920

agaaaatctt gctgctccgt cttagcattc caagaaagtg cttccaggta tttagatagc     1980

cctcagttct caaatattag actacgtgta aaatcttggg tacctttaga ttcttgtaac     2040

actagtctgt actccctttt ccttccccaa gactgatagg atgcaagctg aggtcgtggc     2100

acaggaatga cagacaccat ttggggagta tccacagagt caaaggaaca ctagaatccc     2160

cacctcagcg tgaggataat tgatttccag ctgcaataag ccgtgcctca ttatagccac     2220

actgtggcta gattatactt ctttgggtgc tgtgctaaga atgtcaatgg aaaaagccga     2280

tctcagattt tgtttgaagt taacatgcct gacacagaca tcctttcctc tcacaagctg     2340

tgtgacttag tagataaaat actgccttct gcctttggga ccatgattaa aaacaaagac     2400

aaaaaccaaa agtcattaaa aaaaaaaaaa aaaaaaaccc agcttgagag cattggaaaa     2460

aaaaaatatg agctgaatgt ctaatggatg ctaagtccag ttttcagaac cactgtacat     2520

tccacggcac agttagcagt gcctgcctgg aaaagttttg gaggtcatcg tggaagttgc     2580

tttgcctcct gtcagtgtcc cctttccctg ctaccaaaaa agtctttcaa ggatggagct     2640

aaggtcaaaa atgagtgaaa aaacttgcag tgtttgtatc cattaaacgg aagccccctc     2700

actctgagag gtcactagag gacttcatag tggggttgtg ctgcttatca cagatgcaga     2760

cacttgccca gataggagca gagaaaagca ggggacgttt cctactcaca ttgtggctgt     2820

atgagaacac gatgggactg ctttgctgtt ctctttactc tgtccttgga gaggtgtgaa     2880

aagctgtatt gctacaggca atttatttaa taattggaag ccatattgat aatggatgtg     2940

gtaatatttg taaagtttaa tctactttaa gcggcagtaa ctaatggaat ttttttcctt     3000

gatcacatat gtagcacttt tgttactttt taaagatatt tatatttgat aaatcttttt     3060

ttcattttga gaactcaaaa taccaaacag tgaacttgca ttctaaagtc accctgtgat     3120

caccttgtca tctagtagca aaatgatgaa ctattcatgc atcaaagaaa attacatctg     3180

ctggccttgt atgaaaatga tctcttggca tcccgattaa atgacacact gtcactgtgg     3240

gtaa                                                                  3244


<210> 4669
<211> 811
<212> DNA
<213> Homo sapiens

<400> 4669
gttgatatca atatggcggt tgtcagccag acaaagacag tcagtctgat gtgattgaga       60

caagggaggt ttttcagggg gagactggga gataggggcc tcccctcccc cttctcctct      120

tcctgcgccg gcctcaaccc ctccccagtc ccctcccgac gggcgcccca cgcggaagac      180

acccctcccc ctcccgcctt ccctcctccc tatctcagcc cttcgtactg ggacgttggg      240

gagggggctg tgccgggcgg agagaactca gcgaggattc tgagagtttc gctcttgtcc      300

atgctggagt gcaatggtgt aatctcagct caccacaacc tccgcctcct gggttcaagt      360

gattctcctg cctcagcttc ctgagtagct gggattacag aatggtagat aacgcagatc      420

atctctggaa aggatattga tccgcctcat gtaaagtatg cttagttcct ttccagtggt      480

tttgctggaa accatgtctc attatacaga tgaacccaga tttaccatag agcagataga      540

tctgcttcag cgacttcggc gtactggaat gactaaacat gaaattctcc atgccttgga      600

aactttggac cgtcttgatc aagagcatag tgacaagttt ggaagaaggt ccagctatgg      660

aggaagttca tatgggaata gtactaacaa tgtcccagca tcttcctcta cagctacagc      720

ttccacacag acgcagcatt cgggaatgtc cccgtcacct agcaacagtt atgatacttc      780

cccacagcct tgcactacca atcaaaatgg g                                     811


<210> 4670
<211> 1731
<212> DNA
<213> Homo sapiens

<400> 4670
aaagtatgct tagttccttt ccagtggttt tgctggaaac catgtctcat tatacagatg       60

aacccagatt taccatagag cagatagatc tgcttcagcg acttcggcgt actggaatga      120

ctaaacatga aattctccat gccttggaaa ctttggaccg tcttgatcaa gagcatagtg      180

acaagtttgg aagaaggtcc agctatggag gaagttcata tgggaatagt actaacaatg      240

tcccagcatc ttcctctaca gctacagctt ccacacagac gcagcattcg ggaatgtccc      300

cgtcacctag caacagttat gatacttccc cacagccttg cactaccaat caaaatggga      360

gggagaataa tgagcgatta tctacatcca atggaaagat gtcaccaact cgctaccatg      420

caaacagcat gggtcagagg tcatacagtt ttgaagcctc agaagaggac ctagatgtag      480

atgataaagt ggaagaatta atgaggaggg acagcagtgt gataaaagag gaaatcaaag      540

cctttcttgc caatcggagg atttcccaag cagttgttgc acaggtaaca ggtatcagtc      600

agagccggat ctctcattgg ctgttgcagc agggatcaga cctgagtgaa cagaagaaaa      660

gagcatttta ccgatggtat caacttgaga agacaaaccc tggcgctaca ctaagtatga      720

gaccagcccc cattccaata gaggaccctg aatggagaca aacgcctccc ccagtctctg      780

ccacatctgg tactttccga ctgcgacgag ggagtcgatt tacctggaga aaggagtgcc      840

tggctgttat ggaaagttac ttcaatgaga atcaataccc agatgaagca aagagggaag      900

aaattgcaaa cgcttgcaat gcagttatac agaagccagg caaaaagctg tcagatctgg      960

aaagagttac ctccctgaaa gtatataatt ggtttgctaa cagaaggaag gagatcaaga     1020

ggagagccaa tattgcagca atcctggaga gtcatgggat agatgtgcag agtccaggag     1080

gccactcaaa cagtgatgat gtcgacggga atgactactc tgagcaggat acttggcaag     1140

tacgcaatgg ggaggaggag gagggaagaa gttcagaggg aggcagagaa gcagagaagg     1200

atgacagtac gagccatagt gaccaccaag accccatctc attagctgtg gaaatggcag     1260

cagtcaacca cactatcttg gcattggccc gacaaggagc caacgaaatc aagacagagg     1320

ccctggatga tgactgatca gggaggttaa acatgacaag ttaacttagt ttagacgtag     1380

caccttagca gactttcctc ggtccttaac atgtgttctt acagtataac ttgcagtttc     1440

ttgtatgtca ggtagctgtt agggtcttgt tctgtgaaga tggcatggtg ccctcagcct     1500

ttgcatatac tctctcagta ttaactccca gtaaataata accaaccaac caaccaaact     1560

tccctctccc agcccccgag gctagaaaat cttgctgctc cgtcttagca ttccaagaaa     1620

gtgcttccag gtatttagat agccctcagt tctcaaatat tagactacgt gtaaaatctt     1680

gggtaccttt agattcttgt aacactagtc tgtactccct tttccttccc c              1731


<210> 4671
<211> 1765
<212> DNA
<213> Homo sapiens

<400> 4671
gttgatatca atatggcggt tgtcagccag acaaagacag tcagtctgat gtgattgaga       60

caagggaggt ttttcagggg gagactggga gataggggcc tcccctcccc cttctcctct      120

tcctgcgccg gcctcaaccc ctccccagtc ccctcccgac gggcgcccca cgcggaagac      180

acccctcccc ctcccgcctt ccctcctccc tatctcagcc cttcgtactg ggacgttggg      240

gagggggctg tgccgggcgg agagaactca gcgaggattc tgagaatggt agataacgca      300

gatcatctct ggaaaggata ttgatccgcc tcatgtaaag tatgcttagt tcctttccag      360

tggttttgct ggaaaccatg tctcattata cagatgaacc cagatttacc atagagcaga      420

tagatctgct tcagcgactt cggcgtactg gaatgactaa acatgaaatt ctccatgcct      480

tggaaacttt ggaccgtctt gatcaagagc atagtgacaa gtttggaaga aggtccagct      540

atggaggaag ttcatatggg aatagtacta acaatgtccc agcatcttcc tctacagcta      600

cagcttccac acagacgcag cattcgggaa tgtccccgtc acctagcaac agttatgata      660

cttccccaca gccttgcact accaatcaaa atgggaggga gaataatgag cgattatcta      720

catccaatgg aaagatgtca ccaactcgct accatgcaaa cagcatgggt cagaggtcat      780

acagttttga agcctcagaa gaggacctag atgtagatga taaagtggaa gaattaatga      840

ggagggacag cagtgtgata aaagaggaaa tcaaagcctt tcttgccaat cggaggattt      900

cccaagcagt tgttgcacag gtaacaggta tcagtcagag ccggatctct cattggctgt      960

tgcagcaggg atcagacctg agtgaacaga agaaaagagc attttaccga tggtatcaac     1020

ttgagaagac aaaccctggc gctacactaa gtatgagacc agcccccatt ccaatagagg     1080

accctgaatg gagacaaacg cctcccccag tctctgccac atctggtact ttccgactgc     1140

gacgagggag tcgatttacc tggagaaagg agtgcctggc tgttatggaa agttacttca     1200

atgagaatca atacccagat gaagcaaaga gggaagaaat tgcaaacgct tgcaatgcag     1260

ttatacagaa gccaggcaaa aagctgtcag atctggaaag agttacctcc ctgaaagtat     1320

ataattggtt tgctaacaga aggaaggaga tcaagaggag agccaatatt gcagcaatcc     1380

tggagagtca tgggatagat gtgcagagtc caggaggcca ctcaaacagt gatgatgtcg     1440

acgggaatga ctactctgag caggatactt ggcaagtacg caatggggag gaggaggagg     1500

gaagaagttc agagggaggc agagaagcag agaaggtaga agaagagagg aggatctgat     1560

ccaaacaagc aagttacacc attcacgaca cacactcagt gtttgagaaa tactaggggc     1620

agctggaccc catgcctaaa cacgtaccga cgcagggcac gatggaaggc cccactcact     1680

ctggccccac tgcagtggga accctcctgc ccaaaggagt ggttcttcca gagtctctgg     1740

cacactgaca catgcatcct ctcat                                           1765


<210> 4672
<211> 459
<212> PRT
<213> Homo sapiens

<400> 4672
Met Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala 
1               5                   10                  15      


Pro Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly 
            20                  25                  30          


Val Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met 
        35                  40                  45              


Ile Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly 
    50                  55                  60                  


Thr Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp 
65                  70                  75                  80  


Leu Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr 
                85                  90                  95      


Met Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala 
            100                 105                 110         


Tyr Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu 
        115                 120                 125             


Val Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu 
    130                 135                 140                 


Glu Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly 
145                 150                 155                 160 


Tyr Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly 
                165                 170                 175     


Tyr Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile 
            180                 185                 190         


Gly Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile 
        195                 200                 205             


Gln Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser 
    210                 215                 220                 


Tyr Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn 
225                 230                 235                 240 


Ala Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys 
                245                 250                 255     


Glu Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile 
            260                 265                 270         


Val Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln 
        275                 280                 285             


Ala Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser 
    290                 295                 300                 


Ser Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala 
305                 310                 315                 320 


Ser His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser 
                325                 330                 335     


Ala Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn 
            340                 345                 350         


Glu Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp 
        355                 360                 365             


Phe Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro 
    370                 375                 380                 


Asn Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile 
385                 390                 395                 400 


Arg Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu 
                405                 410                 415     


Arg Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly 
            420                 425                 430         


Asp His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr 
        435                 440                 445             


Ala Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
    450                 455                 


<210> 4673
<211> 158
<212> PRT
<213> Homo sapiens

<400> 4673
Met Glu Pro Pro Glu Gly Ala Gly Thr Gly Glu Ile Val Lys Glu Ala 
1               5                   10                  15      


Glu Val Pro Gln Ala Ala Leu Gly Val Pro Ala Gln Gly Thr Gly Asp 
            20                  25                  30          


Asn Gly His Thr Pro Val Glu Glu Glu Val Gly Gly Ile Pro Val Pro 
        35                  40                  45              


Ala Pro Gly Leu Leu Gln Val Thr Glu Arg Arg Gln Pro Leu Ser Ser 
    50                  55                  60                  


Val Ser Ser Leu Glu Val His Phe Asp Leu Leu Asp Leu Thr Glu Leu 
65                  70                  75                  80  


Thr Asp Met Ser Asp Gln Glu Leu Ala Glu Val Phe Ala Asp Ser Asp 
                85                  90                  95      


Asp Glu Asn Leu Asn Thr Glu Ser Pro Ala Gly Leu His Pro Leu Pro 
            100                 105                 110         


Arg Ala Gly Tyr Leu Arg Ser Pro Ser Trp Thr Arg Thr Arg Ala Glu 
        115                 120                 125             


Gln Ser His Glu Lys Gln Pro Leu Gly Asp Pro Glu Arg Gln Ala Thr 
    130                 135                 140                 


Val Leu Asp Thr Phe Leu Thr Val Glu Arg Pro Gln Glu Asp 
145                 150                 155             


<210> 4674
<211> 317
<212> PRT
<213> Homo sapiens

<400> 4674
Met Ala Ser Val Ile Pro Ala Ser Asn Arg Ser Met Arg Ser Asp Arg 
1               5                   10                  15      


Asn Thr Tyr Val Gly Lys Arg Phe Val His Val Lys Asn Pro Tyr Leu 
            20                  25                  30          


Asp Leu Met Asp Glu Asp Ile Leu Tyr His Leu Asp Leu Gly Thr Lys 
        35                  40                  45              


Thr His Asn Leu Pro Ala Met Phe Gly Asp Val Lys Phe Val Cys Val 
    50                  55                  60                  


Gly Gly Ser Pro Asn Arg Met Lys Ala Phe Ala Leu Phe Met His Lys 
65                  70                  75                  80  


Glu Leu Gly Phe Glu Glu Ala Glu Glu Asp Ile Lys Asp Ile Cys Ala 
                85                  90                  95      


Gly Thr Asp Arg Tyr Cys Met Tyr Lys Thr Gly Pro Val Leu Ala Ile 
            100                 105                 110         


Ser His Gly Met Gly Ile Pro Ser Ile Ser Ile Met Leu His Glu Leu 
        115                 120                 125             


Ile Lys Leu Leu His His Ala Arg Cys Cys Asp Val Thr Ile Ile Arg 
    130                 135                 140                 


Ile Gly Thr Ser Gly Gly Ile Gly Ile Ala Pro Gly Thr Val Val Ile 
145                 150                 155                 160 


Thr Asp Ile Ala Val Asp Ser Phe Phe Lys Pro Arg Phe Glu Gln Val 
                165                 170                 175     


Ile Leu Asp Asn Ile Val Thr Arg Ser Thr Glu Leu Asp Lys Glu Leu 
            180                 185                 190         


Ser Glu Glu Leu Phe Asn Cys Ser Lys Glu Ile Pro Asn Phe Pro Thr 
        195                 200                 205             


Leu Val Gly His Thr Met Cys Thr Tyr Asp Phe Tyr Glu Gly Gln Gly 
    210                 215                 220                 


Arg Leu Asp Gly Ala Leu Cys Ser Phe Ser Arg Glu Lys Lys Leu Asp 
225                 230                 235                 240 


Tyr Leu Lys Arg Ala Phe Lys Ala Gly Val Arg Asn Ile Glu Met Glu 
                245                 250                 255     


Ser Thr Val Phe Ala Ala Met Cys Gly Leu Cys Gly Leu Lys Ala Ala 
            260                 265                 270         


Val Val Cys Val Thr Leu Leu Asp Arg Leu Asp Cys Asp Gln Ile Asn 
        275                 280                 285             


Leu Pro His Asp Val Leu Val Glu Tyr Gln Gln Arg Pro Gln Leu Leu 
    290                 295                 300                 


Ile Ser Asn Phe Ile Arg Arg Arg Leu Gly Leu Cys Asp 
305                 310                 315         


<210> 4675
<211> 364
<212> PRT
<213> Homo sapiens

<400> 4675
Met Ser Glu Val Glu Ala Ala Ala Gly Ala Thr Ala Val Pro Ala Ala 
1               5                   10                  15      


Thr Val Pro Ala Thr Ala Ala Gly Val Val Ala Val Val Val Pro Val 
            20                  25                  30          


Pro Ala Gly Glu Pro Gln Lys Gly Gly Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Ala Ala Ser Gly Pro Ala Ala Gly Thr Pro Ser Ala Pro Gly Ser Arg 
    50                  55                  60                  


Thr Pro Gly Asn Pro Ala Thr Ala Val Ser Gly Thr Pro Ala Pro Pro 
65                  70                  75                  80  


Ala Arg Ser Gln Ala Asp Lys Pro Val Leu Ala Ile Gln Val Leu Gly 
                85                  90                  95      


Thr Val Lys Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg 
            100                 105                 110         


Asn Asp Thr Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Arg 
        115                 120                 125             


Asn Asn Pro Arg Lys Phe Leu Arg Ser Val Gly Asp Gly Glu Thr Val 
    130                 135                 140                 


Glu Phe Asp Val Val Glu Gly Glu Lys Gly Ala Glu Ala Thr Asn Val 
145                 150                 155                 160 


Thr Gly Pro Gly Gly Val Pro Val Lys Gly Ser Arg Tyr Ala Pro Asn 
                165                 170                 175     


Arg Arg Lys Ser Arg Arg Phe Ile Pro Arg Pro Pro Ser Val Ala Pro 
            180                 185                 190         


Pro Pro Met Val Ala Glu Ile Pro Ser Ala Gly Thr Gly Pro Gly Ser 
        195                 200                 205             


Lys Gly Glu Arg Ala Glu Asp Ser Gly Gln Arg Pro Arg Arg Trp Cys 
    210                 215                 220                 


Pro Pro Pro Phe Phe Tyr Arg Arg Arg Phe Val Arg Gly Pro Arg Pro 
225                 230                 235                 240 


Pro Asn Gln Gln Gln Pro Ile Glu Gly Thr Asp Arg Val Glu Pro Lys 
                245                 250                 255     


Glu Thr Ala Pro Leu Glu Gly His Gln Gln Gln Gly Asp Glu Arg Val 
            260                 265                 270         


Pro Pro Pro Arg Phe Arg Pro Arg Tyr Arg Arg Pro Phe Arg Pro Arg 
        275                 280                 285             


Pro Arg Gln Gln Pro Thr Thr Glu Gly Gly Asp Gly Glu Thr Lys Pro 
    290                 295                 300                 


Ser Gln Gly Pro Ala Asp Gly Ser Arg Pro Glu Pro Gln Arg Pro Arg 
305                 310                 315                 320 


Asn Arg Pro Tyr Phe Gln Arg Arg Arg Gln Gln Ala Pro Gly Pro Gln 
                325                 330                 335     


Gln Ala Pro Gly Pro Arg Gln Pro Ala Ala Pro Glu Thr Ser Ala Pro 
            340                 345                 350         


Val Asn Ser Gly Asp Pro Thr Thr Thr Ile Leu Glu 
        355                 360                 


<210> 4676
<211> 1901
<212> PRT
<213> Homo sapiens

<400> 4676
Met Ala Thr Phe Arg Asn Asn His Met Lys Thr Lys Ala Ser Val Arg 
1               5                   10                  15      


Lys Ser Phe Ser Glu Asp Val Phe Gln Ser Val Lys Ser Leu Leu Gln 
            20                  25                  30          


Ser Gln Lys Glu Leu Cys Ser Val Thr Ala Glu Asp Cys Leu Gln Gln 
        35                  40                  45              


Asp Glu His Ala Asn Leu Thr Glu Val Thr Phe Leu Gly Phe Asn Glu 
    50                  55                  60                  


Glu Thr Asp Ala Ala His Ile Gln Asp Leu Ala Ala Val Ser Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Ile Leu Asn Ser Leu His Phe Cys Ser Leu Asn Glu Asn 
                85                  90                  95      


Glu Ile Ile Cys Met Lys Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser 
            100                 105                 110         


Asp Pro Leu Asn Gln Ser His Pro Ser Gly Met Leu Cys Val Met Arg 
        115                 120                 125             


Val Ser Pro Thr Ser Pro Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu 
    130                 135                 140                 


Leu Ser Lys Tyr Ala Thr Gly Ile Arg Tyr Thr Leu Asp Thr Phe Leu 
145                 150                 155                 160 


His Gln Lys His Gln Leu Glu Thr Thr Asp Glu Asp Asp Asp Asp Thr 
                165                 170                 175     


Asn Gln Ser Val Ser Ser Ile Glu Asp Asp Phe Val Thr Ala Phe Glu 
            180                 185                 190         


His Leu Glu Glu Glu Glu Thr Ser Lys Pro Tyr Asn Asp Gly Met Asn 
        195                 200                 205             


Ile Thr Val Leu Arg Ser Gln Cys Asp Ala Ala Ser Gln Thr Val Thr 
    210                 215                 220                 


Gly His His Leu Glu Thr His Asp Leu Lys Ile Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Gln Gln Lys Ser Leu Ala Lys Pro Ser Thr Ser Ser Val Asn Val Leu 
                245                 250                 255     


Gly His Lys Glu Leu Pro Ser Val Lys Thr Ser Val Thr Thr Ser Ile 
            260                 265                 270         


Ser Glu Pro Trp Thr Gln Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser 
        275                 280                 285             


Asp Lys Asp Ser Asp Leu Gln Lys Thr Phe Phe Ser Ser Ser Pro Ala 
    290                 295                 300                 


Tyr Ser Ser Glu Ser Glu Cys Ser Ser Pro Ser Pro Val Ile Phe Leu 
305                 310                 315                 320 


Asp Glu Glu Gly Tyr Gln Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro 
                325                 330                 335     


Lys Ile Pro Val Met Lys Asp Asp Ile Glu Asp Ser Asp Ser Glu Val 
            340                 345                 350         


Ser Glu Phe Phe Asp Ser Phe Asp Gln Phe Asp Glu Leu Glu Gln Thr 
        355                 360                 365             


Leu Glu Thr Cys Leu Phe Asn Lys Asp Pro Val Ile Gly Lys Ser Ser 
    370                 375                 380                 


Gln Arg Lys Gly His Lys His Gly Lys Ser Cys Met Asn Pro Gln Lys 
385                 390                 395                 400 


Phe Lys Phe Asp Arg Pro Ala Leu Pro Ala Asn Val Arg Lys Pro Thr 
                405                 410                 415     


Pro Arg Lys Pro Glu Ser Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp 
            420                 425                 430         


Ser Pro Arg Pro Val Lys Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser 
        435                 440                 445             


Pro Ile Arg Ser Ser Ala Phe Ser Pro Leu Gly Gly Cys Thr Pro Ala 
    450                 455                 460                 


Glu Cys Phe Cys Gln Thr Asp Ile Gly Gly Asp Arg Ile His Glu Asn 
465                 470                 475                 480 


His Asp Ser Val Tyr Tyr Thr Tyr Glu Asp Tyr Ala Lys Ser Ile Ser 
                485                 490                 495     


Cys Glu Val Leu Gly Ser Val Leu Arg Thr His His Thr Asn Thr Leu 
            500                 505                 510         


Ser Asn Ile Asn Ser Ile Lys His Gly Glu Asn Lys Thr Val Thr Phe 
        515                 520                 525             


Lys His Gly Asn Leu Asp Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu 
    530                 535                 540                 


Met Ile Lys Asp Ser Ile Gln Lys Phe Ala Ala Asp Leu Val Glu Lys 
545                 550                 555                 560 


Ser Phe Gly Ser Ala Phe Lys Asp Leu Gln Lys Gly Val Ser Ser Cys 
                565                 570                 575     


Thr Asn Ala Leu Tyr His Leu Ala Ile Lys Leu Thr Ser Ser Val Leu 
            580                 585                 590         


Gln Met Ala Phe Asp Glu Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys 
        595                 600                 605             


Glu Arg Ala Ile Ser Gly Leu Ala Asn Phe Leu Val Ser Glu Ala Leu 
    610                 615                 620                 


Ser Asn Ala Leu Lys Asp Leu Gln Tyr Val Lys Lys Gln Ile Phe Thr 
625                 630                 635                 640 


Asn Thr Val Ala Arg Phe Ala Ala Asp Leu Ala Glu Glu Leu Val Phe 
                645                 650                 655     


Glu Gly Ile Met Glu Val Cys Gln Phe Ser Tyr Pro Gln Thr Pro Ala 
            660                 665                 670         


Ser Pro Gln Cys Gly Ser Phe Asp Phe Glu Asp Lys Val Val Lys Leu 
        675                 680                 685             


Tyr Ala Lys Asp Leu Ser Glu Ser Val Ile Gln Glu Ala Phe Ile Glu 
    690                 695                 700                 


Leu Ser Gln Val Asp Val Thr Phe Thr Thr Lys Ala Ala Val Ser Val 
705                 710                 715                 720 


Ser Thr Asp Asn Ile Lys Tyr Val Ser Ala Glu Ser Val Val Pro Ser 
                725                 730                 735     


Thr Gln Ala Val Thr Phe Ser Pro Ser Phe His Asn Gln Ala Ile Met 
            740                 745                 750         


Val Thr Lys Pro Val Gln Glu Tyr Lys Lys Glu Tyr Thr Val Gln Gln 
        755                 760                 765             


Ala Leu Phe Cys Thr Ser Gly Ile Val Thr Ser Ile Pro Val Pro Leu 
    770                 775                 780                 


Ala Gly Ser Ala Leu Leu Pro Tyr His Ile Ser Ser Thr Ala Cys Gln 
785                 790                 795                 800 


Ala Lys Ala His Leu Ser Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser 
                805                 810                 815     


Ala Gln Val His Ile Ala Thr Lys Asn Arg Glu Glu Lys Ala Ala Cys 
            820                 825                 830         


Leu Arg Asn Ile Cys Leu Pro Ser Glu His Asn Pro Gly Asn Gln Asn 
        835                 840                 845             


Asp Phe Lys Pro Thr Asn Asp Asp Ile Glu Met Gln Ser Ser Ser Lys 
    850                 855                 860                 


Leu Pro Asn Asp Pro Ala Ile Ile Ser Asn Phe Ser Ala Ala Val Val 
865                 870                 875                 880 


His Thr Ile Val Asn Glu Thr Leu Glu Ser Met Thr Ser Leu Glu Val 
                885                 890                 895     


Thr Lys Met Val Asp Glu Arg Thr Asp Tyr Leu Thr Lys Ser Leu Lys 
            900                 905                 910         


Glu Lys Thr Pro Pro Phe Ser His Cys Asp Gln Ala Val Leu Gln Cys 
        915                 920                 925             


Ser Glu Ala Ser Ser Asn Lys Asp Met Phe Ala Asp Arg Leu Ser Lys 
    930                 935                 940                 


Ser Ile Ile Lys His Ser Ile Asp Lys Ser Lys Ser Val Ile Pro Asn 
945                 950                 955                 960 


Ile Asp Lys Asn Ala Val Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu 
                965                 970                 975     


Glu Ser Gln Leu Thr Pro Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln 
            980                 985                 990         


Asn Gln Leu Thr His Cys Ser Leu  Ser Ala Ala Lys Asp  Cys Val Pro 
        995                 1000                 1005             


Glu Cys  Lys Val Ser Met Val  His Gly Ser Ser Leu  Glu Thr Leu 
    1010                 1015                 1020             


Pro Ser  Cys Pro Ala Val Thr  Gly Gln Lys Ser Asp  Leu Lys Glu 
    1025                 1030                 1035             


Ser Ala  Lys Asp Gln Pro Leu  Lys Lys His Asn Leu  Asn Ser Thr 
    1040                 1045                 1050             


Ser Leu  Glu Ala Leu Ser Phe  Gly Gln Glu Asn Pro  Phe Pro His 
    1055                 1060                 1065             


Ser His  Thr Phe Ser Ser Thr  Ala Leu Thr Cys Val  Asp Gly Leu 
    1070                 1075                 1080             


His Val  Glu Asp Lys Gln Lys  Val Arg Asp Arg Asn  Val Ile Pro 
    1085                 1090                 1095             


Asp Thr  Pro Pro Ser Thr Pro  Leu Val Pro Ser Arg  Ala Ser Ser 
    1100                 1105                 1110             


Glu Trp  Asp Ile Lys Lys Leu  Thr Lys Lys Leu Lys  Gly Glu Leu 
    1115                 1120                 1125             


Ala Lys  Glu Phe Ala Pro Ala  Thr Pro Pro Ser Thr  Pro His Asn 
    1130                 1135                 1140             


Ser Ser  Val Gly Ser Leu Ser  Glu Asn Glu Gln Asn  Thr Ile Glu 
    1145                 1150                 1155             


Lys Glu  Glu Phe Met Leu Lys  Leu Met Arg Ser Leu  Ser Glu Glu 
    1160                 1165                 1170             


Val Glu  Ser Ser Glu Ser Gly  Glu Leu Pro Glu Val  Asp Val Lys 
    1175                 1180                 1185             


Ser Glu  His Ser Gly Lys Lys  Val Gln Phe Ala Glu  Ala Leu Ala 
    1190                 1195                 1200             


Thr His  Ile Leu Ser Leu Ala  Thr Glu Met Ala Ala  Ser His Leu 
    1205                 1210                 1215             


Asp Asn  Lys Ile Ile Gln Glu  Pro Lys Val Lys Asn  Pro Cys Leu 
    1220                 1225                 1230             


Asn Val  Gln Ser Gln Arg Ser  Val Ser Pro Thr Phe  Leu Asn Pro 
    1235                 1240                 1245             


Ser Asp  Glu Asn Leu Lys Thr  Leu Cys Asn Phe Ala  Gly Asp Leu 
    1250                 1255                 1260             


Ala Ala  Glu Val Ile Thr Glu  Ala Glu Lys Ile Ala  Lys Val Arg 
    1265                 1270                 1275             


Asn Cys  Met Leu Phe Lys Gln  Lys Lys Asn Ser Cys  Tyr Ala Asp 
    1280                 1285                 1290             


Gly Asp  Glu Asp Tyr Lys Val  Glu Glu Lys Leu Asp  Ile Glu Ala 
    1295                 1300                 1305             


Val Val  His Pro Arg Glu Val  Asp Pro Phe Ile Leu  Ser Leu Pro 
    1310                 1315                 1320             


Pro Ser  Ser Cys Met Ser Gly  Leu Met Tyr Lys Tyr  Pro Ser Cys 
    1325                 1330                 1335             


Glu Ser  Val Thr Asp Glu Tyr  Ala Gly His Leu Ile  Gln Ile Leu 
    1340                 1345                 1350             


Lys Gln  Glu Gly Gly Asn Ser  Glu Leu Ile Met Asp  Gln Tyr Ala 
    1355                 1360                 1365             


Asn Arg  Leu Ala Tyr Arg Ser  Val Lys Ser Gly Leu  Gln Glu Ala 
    1370                 1375                 1380             


Ala Lys  Thr Thr Lys Val Gln  Cys Asn Ser Arg Met  Phe Pro Val 
    1385                 1390                 1395             


Pro Ser  Ser Gln Val Lys Thr  Asn Lys Glu Leu Leu  Met Phe Ser 
    1400                 1405                 1410             


Asn Lys  Glu His His Gln Glu  Ala Asp Lys Lys Arg  Gln Ser Lys 
    1415                 1420                 1425             


Arg Asn  Glu Gly Tyr Phe Cys  Lys Asn Gln Thr Cys  Glu Arg Thr 
    1430                 1435                 1440             


Leu Asp  Pro Tyr Arg Asn Glu  Val Ser Gln Leu Tyr  Ser Phe Ser 
    1445                 1450                 1455             


Thr Ser  Leu Val His Ser Ile  Thr Lys Asp Ala Lys  Glu Glu Leu 
    1460                 1465                 1470             


Thr Ala  Ser Leu Val Gly Leu  Pro Lys Ser Leu Thr  Asp Ser Cys 
    1475                 1480                 1485             


Leu Phe  Glu Lys Ser Gly Tyr  Glu Glu Asp Asn Glu  Cys His Val 
    1490                 1495                 1500             


Thr Pro  Glu Leu Pro Lys Ser  Leu Gln Pro Ser Ser  Gln Asn His 
    1505                 1510                 1515             


Arg Phe  Tyr His Ser Thr Gly  Ser Leu Asn Gly Tyr  Gly Cys Gly 
    1520                 1525                 1530             


Asp Asn  Val Val Gln Ala Val  Glu Gln Tyr Ala Lys  Lys Val Val 
    1535                 1540                 1545             


Asp Asp  Thr Leu Glu Leu Thr  Leu Gly Ser Thr Val  Phe Arg Val 
    1550                 1555                 1560             


Ser Glu  Thr Thr Lys Ser Ala  Asp Arg Val Thr Tyr  Ala Glu Lys 
    1565                 1570                 1575             


Leu Ser  Pro Leu Thr Gly Gln  Ala Cys Arg Tyr Cys  Asp Leu Lys 
    1580                 1585                 1590             


Glu Leu  His Asn Cys Thr Gly  Asn Ser Ser Gln His  Phe Phe Arg 
    1595                 1600                 1605             


Gln Gly  Ser Leu Ala Ser Ser  Lys Pro Ala Ser Asn  Pro Lys Phe 
    1610                 1615                 1620             


Ser Ser  Arg Tyr Gln Lys Ser  Arg Ile Phe His Leu  Ser Val Pro 
    1625                 1630                 1635             


Gln Ile  His Val Asn Leu Asp  Lys Lys Ala Val Leu  Ala Glu Lys 
    1640                 1645                 1650             


Ile Val  Ala Glu Ala Ile Glu  Lys Ala Glu Arg Glu  Leu Ser Ser 
    1655                 1660                 1665             


Thr Ser  Leu Ala Ala Asp Ser  Gly Ile Gly Gln Glu  Gly Ala Ser 
    1670                 1675                 1680             


Phe Ala  Glu Ser Leu Ala Thr  Glu Thr Met Thr Ala  Ala Val Thr 
    1685                 1690                 1695             


Asn Val  Gly His Ala Val Ser  Ser Ser Lys Glu Ile  Glu Asp Phe 
    1700                 1705                 1710             


Gln Ser  Thr Glu Ser Val Ser  Ser Gln Gln Met Asn  Leu Ser Ile 
    1715                 1720                 1725             


Gly Asp  Asp Ser Thr Gly Ser  Trp Ser Asn Leu Ser  Phe Glu Asp 
    1730                 1735                 1740             


Glu His  Gln Asp Glu Ser Ser  Ser Phe His His Leu  Ser Glu Ser 
    1745                 1750                 1755             


Asn Gly  Asn Ser Ser Ser Trp  Ser Ser Leu Gly Leu  Glu Gly Asp 
    1760                 1765                 1770             


Leu Tyr  Glu Asp Asn Leu Ser  Phe Pro Thr Ser Asp  Ser Asp Gly 
    1775                 1780                 1785             


Pro Asp  Asp Lys Asp Glu Glu  His Glu Asp Glu Val  Glu Gly Leu 
    1790                 1795                 1800             


Gly Gln  Asp Gly Lys Thr Leu  Leu Ile Thr Asn Ile  Asp Met Glu 
    1805                 1810                 1815             


Pro Cys  Thr Val Asp Pro Gln  Leu Arg Ile Ile Leu  Gln Trp Leu 
    1820                 1825                 1830             


Ile Ala  Ser Glu Ala Glu Val  Ala Glu Leu Tyr Phe  His Asp Ser 
    1835                 1840                 1845             


Ala Asn  Lys Glu Phe Met Leu  Leu Ser Lys Gln Leu  Gln Glu Lys 
    1850                 1855                 1860             


Gly Trp  Lys Val Gly Asp Leu  Leu Gln Ala Val Leu  Gln Tyr Tyr 
    1865                 1870                 1875             


Glu Val  Met Glu Lys Ala Ser  Ser Glu Glu Arg Cys  Lys Ser Leu 
    1880                 1885                 1890             


Phe Asp  Trp Leu Leu Glu Asn  Ala 
    1895                 1900     


<210> 4677
<211> 138
<212> PRT
<213> Homo sapiens

<400> 4677
Met Ala Glu Leu Gln Gln Leu Arg Val Gln Glu Ala Val Glu Ser Met 
1               5                   10                  15      


Val Lys Ser Leu Glu Arg Glu Asn Ile Arg Lys Met Gln Gly Leu Met 
            20                  25                  30          


Phe Arg Cys Ser Ala Ser Cys Cys Glu Asp Ser Gln Ala Ser Met Lys 
        35                  40                  45              


Gln Val His Gln Cys Ile Glu Arg Cys His Val Pro Leu Ala Gln Ala 
    50                  55                  60                  


Gln Ala Leu Val Thr Ser Glu Leu Glu Lys Phe Gln Asp Arg Leu Ala 
65                  70                  75                  80  


Arg Cys Thr Met His Cys Asn Asp Lys Ala Lys Asp Ser Ile Asp Ala 
                85                  90                  95      


Gly Ser Lys Glu Leu Gln Val Lys Gln Gln Leu Asp Ser Cys Val Thr 
            100                 105                 110         


Lys Cys Val Asp Asp His Met His Leu Ile Pro Thr Met Thr Lys Lys 
        115                 120                 125             


Met Lys Glu Ala Leu Leu Ser Ile Gly Lys 
    130                 135             


<210> 4678
<211> 369
<212> PRT
<213> Homo sapiens

<400> 4678
Met Thr Leu Glu Ala Ile Arg Tyr Ser Arg Gly Ser Leu Gln Ile Leu 
1               5                   10                  15      


Asp Gln Leu Leu Leu Pro Lys Gln Ser Arg Tyr Glu Ala Val Gly Ser 
            20                  25                  30          


Val His Gln Ala Trp Glu Ala Ile Arg Ala Met Lys Val Arg Gly Ala 
        35                  40                  45              


Pro Ala Ile Ala Leu Val Gly Cys Leu Ser Leu Ala Val Glu Leu Gln 
    50                  55                  60                  


Ala Gly Ala Gly Gly Pro Gly Leu Ala Ala Leu Val Ala Phe Val Arg 
65                  70                  75                  80  


Asp Lys Leu Ser Phe Leu Val Thr Ala Arg Pro Thr Ala Val Asn Met 
                85                  90                  95      


Ala Arg Ala Ala Arg Asp Leu Ala Asp Val Ala Ala Arg Glu Ala Glu 
            100                 105                 110         


Arg Glu Gly Ala Thr Glu Glu Ala Val Arg Glu Arg Val Ile Cys Cys 
        115                 120                 125             


Thr Glu Asp Met Leu Glu Lys Asp Leu Arg Asp Asn Arg Ser Ile Gly 
    130                 135                 140                 


Asp Leu Gly Ala Arg His Leu Leu Glu Arg Val Ala Pro Ser Gly Gly 
145                 150                 155                 160 


Lys Val Thr Val Leu Thr His Cys Asn Thr Gly Ala Leu Ala Thr Ala 
                165                 170                 175     


Gly Tyr Gly Thr Ala Leu Gly Val Ile Arg Ser Leu His Ser Leu Gly 
            180                 185                 190         


Arg Leu Glu His Ala Phe Cys Thr Glu Thr Arg Pro Tyr Asn Gln Gly 
        195                 200                 205             


Ala Arg Leu Thr Ala Phe Glu Leu Val Tyr Glu Gln Ile Pro Ala Thr 
    210                 215                 220                 


Leu Ile Thr Asp Ser Met Val Ala Ala Ala Met Ala His Arg Gly Val 
225                 230                 235                 240 


Ser Ala Val Val Val Gly Ala Asp Arg Val Val Ala Asn Gly Asp Thr 
                245                 250                 255     


Ala Asn Lys Val Gly Thr Tyr Gln Leu Ala Ile Val Ala Lys His His 
            260                 265                 270         


Gly Ile Pro Phe Tyr Val Ala Ala Pro Ser Ser Ser Cys Asp Leu Arg 
        275                 280                 285             


Leu Glu Thr Gly Lys Glu Ile Ile Ile Glu Glu Arg Pro Gly Gln Glu 
    290                 295                 300                 


Leu Thr Asp Val Asn Gly Val Arg Ile Ala Ala Pro Gly Ile Gly Val 
305                 310                 315                 320 


Trp Asn Pro Ala Phe Asp Val Thr Pro His Asp Leu Ile Thr Gly Gly 
                325                 330                 335     


Ile Ile Thr Glu Leu Gly Val Phe Ala Pro Glu Glu Leu Arg Thr Ala 
            340                 345                 350         


Leu Thr Thr Thr Ile Ser Ser Arg Asp Gly Thr Leu Asp Gly Pro Gln 
        355                 360                 365             


Met 
    


<210> 4679
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 4679
Met Met Ser Leu Ser Val Arg Pro Gln Arg Arg Leu Leu Ser Ala Arg 
1               5                   10                  15      


Val Asn Arg Ser Gln Ser Phe Ala Gly Val Leu Gly Ser His Glu Arg 
            20                  25                  30          


Gly Pro Arg Ser Phe Pro Val Phe Ser Pro Pro Gly Pro Pro Arg Lys 
        35                  40                  45              


Pro Pro Ala Leu Ser Arg Val Ser Arg Met Phe Ser Val Ala His Pro 
    50                  55                  60                  


Ala Ala Lys Val Pro Gln Pro Glu Arg Leu Asp Leu Val Tyr Thr Ala 
65                  70                  75                  80  


Leu Lys Arg Gly Leu Thr Ala Tyr Leu Glu Val His Gln Gln Glu Gln 
                85                  90                  95      


Glu Lys Leu Gln Gly Gln Ile Arg Glu Ser Lys Arg Asn Ser Arg Leu 
            100                 105                 110         


Gly Phe Leu Tyr Asp Leu Asp Lys Gln Val Lys Ser Ile Glu Arg Phe 
        115                 120                 125             


Leu Arg Arg Leu Glu Phe His Ala Ser Lys Ile Asp Glu Leu Tyr Glu 
    130                 135                 140                 


Ala Tyr Cys Val Gln Arg Arg Leu Arg Asp Gly Ala Tyr Asn Met Val 
145                 150                 155                 160 


Arg Ala Tyr Thr Thr Gly Ser Pro Gly Ser Arg Glu Ala Arg Asp Ser 
                165                 170                 175     


Leu Ala Glu Ala Thr Arg Gly His Arg Glu Tyr Thr Glu Ser Met Cys 
            180                 185                 190         


Leu Leu Glu Ser Glu Leu Glu Ala Gln Leu Gly Glu Phe His Leu Arg 
        195                 200                 205             


Met Lys Gly Leu Ala Gly Phe Ala Arg Leu Cys Val Gly Asp Gln Tyr 
    210                 215                 220                 


Glu Ile Cys Met Lys Tyr Gly Arg Gln Arg Trp Lys Leu Arg Gly Arg 
225                 230                 235                 240 


Ile Glu Gly Ser Gly Lys Gln Val Trp Asp Ser Glu Glu Thr Ile Phe 
                245                 250                 255     


Leu Pro Leu Leu Thr Glu Phe Leu Ser Ile Lys Val Thr Glu Leu Lys 
            260                 265                 270         


Gly Leu Ala Asn His Val Val Val Gly Ser Val Ser Cys Glu Thr Lys 
        275                 280                 285             


Asp Leu Phe Ala Ala Leu Pro Gln Val Val Ala Val Asp Ile Asn Asp 
    290                 295                 300                 


Leu Gly Thr Ile Lys Leu Ser Leu Glu Val Thr Trp Ser Pro Phe Asp 
305                 310                 315                 320 


Lys Asp Asp Gln Pro Ser Ala Ala Ser Ser Val Asn Lys Ala Ser Thr 
                325                 330                 335     


Val Thr Lys Arg Phe Ser Thr Tyr Ser Gln Ser Pro Pro Asp Thr Pro 
            340                 345                 350         


Ser Leu Arg Glu Gln Ala Phe Tyr Asn Met Leu Arg Arg Gln Glu Glu 
        355                 360                 365             


Leu Glu Asn Gly Thr Ala Trp Ser Leu Ser Ser Glu Ser Ser Asp Asp 
    370                 375                 380                 


Ser Ser Ser Pro Gln Leu Ser Gly Thr Ala Arg His Ser Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Leu Val Gln Gln Pro Glu Pro Leu Pro Ile Gln Val Ala Phe 
                405                 410                 415     


Arg Arg Pro Glu Thr Pro Ser Ser Gly Pro Leu Asp Glu Glu Gly Ala 
            420                 425                 430         


Val Ala Pro Val Leu Ala Asn Gly His Ala Pro Tyr Ser Arg Thr Leu 
        435                 440                 445             


Ser His Ile Ser Glu Ala Ser Val Asp Ala Ala Leu Ala Glu Ala Ser 
    450                 455                 460                 


Val Glu Ala Val Gly Pro Glu Ser Leu Ala Trp Gly Pro Ser Pro Pro 
465                 470                 475                 480 


Thr His Pro Ala Pro Thr His Gly Glu His Pro Ser Pro Val Pro Pro 
                485                 490                 495     


Ala Leu Asp Pro Gly His Ser Ala Thr Ser Ser Thr Leu Gly Thr Thr 
            500                 505                 510         


Gly Ser Val Pro Thr Ser Thr Asp Pro Ala Pro Ser Ala His Leu Asp 
        515                 520                 525             


Ser Val His Lys Ser Thr Asp Ser Gly Pro Ser Glu Leu Pro Gly Pro 
    530                 535                 540                 


Thr His Thr Thr Thr Gly Ser Thr Tyr Ser Ala Ile Thr Thr Thr His 
545                 550                 555                 560 


Ser Ala Pro Ser Pro Leu Thr His Thr Thr Thr Gly Ser Thr His Lys 
                565                 570                 575     


Pro Ile Ile Ser Thr Leu Thr Thr Thr Gly Pro Thr Leu Asn Ile Ile 
            580                 585                 590         


Gly Pro Val Gln Thr Thr Thr Ser Pro Thr His Thr Met Pro Ser Pro 
        595                 600                 605             


Thr His Thr Thr Ala Ser Pro Thr His Thr Ser Thr Ser Pro Thr His 
    610                 615                 620                 


Thr Pro Thr Ser Pro Thr His Lys Thr Ser Met Ser Pro Pro Thr Thr 
625                 630                 635                 640 


Thr Ser Pro Thr Pro Ser Gly Met Gly Leu Val Gln Thr Ala Thr Ser 
                645                 650                 655     


Pro Thr His Pro Thr Thr Ser Pro Thr His Pro Thr Thr Ser Pro Ile 
            660                 665                 670         


Leu Ile Asn Val Ser Pro Ser Thr Ser Leu Glu Leu Ala Thr Leu Ser 
        675                 680                 685             


Ser Pro Ser Lys His Ser Asp Pro Thr Leu Pro Gly Thr Asp Ser Leu 
    690                 695                 700                 


Pro Cys Ser Pro Pro Val Ser Asn Ser Tyr Thr Gln Ala Asp Pro Met 
705                 710                 715                 720 


Ala Pro Arg Thr Pro His Pro Ser Pro Ala His Ser Ser Arg Lys Pro 
                725                 730                 735     


Leu Thr Ser Pro Ala Pro Asp Pro Ser Glu Ser Thr Val Gln Ser Leu 
            740                 745                 750         


Ser Pro Thr Pro Ser Pro Pro Thr Pro Ala Pro Gln His Ser Asp Leu 
        755                 760                 765             


Cys Leu Ala Met Ala Val Gln Thr Pro Val Pro Thr Ala Ala Gly Gly 
    770                 775                 780                 


Ser Gly Asp Arg Ser Leu Glu Glu Ala Leu Gly Ala Leu Met Ala Ala 
785                 790                 795                 800 


Leu Asp Asp Tyr Arg Gly Gln Phe Pro Glu Leu Gln Gly Leu Glu Gln 
                805                 810                 815     


Glu Val Thr Arg Leu Glu Ser Leu Leu Met Gln Arg Gln Gly Leu Thr 
            820                 825                 830         


Arg Ser Arg Ala Ser Ser Leu Ser Ile Thr Val Glu His Ala Leu Glu 
        835                 840                 845             


Ser Phe Ser Phe Leu Asn Glu Asp Glu Asp Glu Asp Asn Asp Val Pro 
    850                 855                 860                 


Gly Asp Arg Pro Pro Ser Ser Pro Glu Ala Gly Ala Glu Asp Ser Ile 
865                 870                 875                 880 


Asp Ser Pro Ser Ala Arg Pro Leu Ser Thr Gly Cys Pro Ala Leu Asp 
                885                 890                 895     


Ala Ala Leu Val Arg His Leu Tyr His Cys Ser Arg Leu Leu Leu Lys 
            900                 905                 910         


Leu Gly Thr Phe Gly Pro Leu Arg Cys Gln Glu Ala Trp Ala Leu Glu 
        915                 920                 925             


Arg Leu Leu Arg Glu Ala Arg Val Leu Glu Ala Val Cys Glu Phe Ser 
    930                 935                 940                 


Arg Arg Trp Glu Ile Pro Ala Ser Ser Ala Gln Glu Val Val Gln Phe 
945                 950                 955                 960 


Ser Ala Ser Arg Pro Gly Phe Leu Thr Phe Trp Asp Gln Cys Thr Glu 
                965                 970                 975     


Arg Leu Ser Cys Phe Leu Cys Pro Val Glu Arg Val Leu Leu Thr Phe 
            980                 985                 990         


Cys Asn Gln Tyr Gly Ala Arg Leu  Ser Leu Arg Gln Pro  Gly Leu Ala 
        995                 1000                 1005             


Glu Ala  Val Cys Val Lys Phe  Leu Glu Asp Ala Leu  Gly Gln Lys 
    1010                 1015                 1020             


Leu Pro  Arg Arg Pro Gln Pro  Gly Pro Gly Glu Gln  Leu Thr Val 
    1025                 1030                 1035             


Phe Gln  Phe Trp Ser Phe Val  Glu Thr Leu Asp Ser  Pro Thr Met 
    1040                 1045                 1050             


Glu Ala  Tyr Val Thr Glu Thr  Ala Glu Glu Val Leu  Leu Val Arg 
    1055                 1060                 1065             


Asn Leu  Asn Ser Asp Asp Gln  Ala Val Val Leu Lys  Ala Leu Arg 
    1070                 1075                 1080             


Leu Ala  Pro Glu Gly Arg Leu  Arg Arg Asp Gly Leu  Arg Ala Leu 
    1085                 1090                 1095             


Ser Ser  Leu Leu Val His Gly  Asn Asn Lys Val Met  Ala Ala Val 
    1100                 1105                 1110             


Ser Thr  Gln Leu Arg Ser Leu  Ser Leu Gly Pro Thr  Phe Arg Glu 
    1115                 1120                 1125             


Arg Ala  Leu Leu Cys Phe Leu  Asp Gln Leu Glu Asp  Glu Asp Val 
    1130                 1135                 1140             


Gln Thr  Arg Val Ala Gly Cys  Leu Ala Leu Gly Cys  Ile Lys Ala 
    1145                 1150                 1155             


Pro Glu  Gly Ile Glu Pro Leu  Val Tyr Leu Cys Gln  Thr Asp Thr 
    1160                 1165                 1170             


Glu Ala  Val Arg Glu Ala Ala  Arg Gln Ser Leu Gln  Gln Cys Gly 
    1175                 1180                 1185             


Glu Glu  Gly Gln Ser Ala His  Arg Arg Leu Glu Glu  Ser Leu Asp 
    1190                 1195                 1200             


Ala Leu  Pro Arg Ile Phe Gly  Pro Gly Ser Met Ala  Ser Thr Ala 
    1205                 1210                 1215             


Phe 
    


<210> 4680
<211> 441
<212> PRT
<213> Homo sapiens

<400> 4680
Met Ala Ser Val Ala Ala Ala Arg Ala Val Pro Val Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Arg Thr Leu Pro Leu Val Val Ile Leu Gly Ala Thr 
            20                  25                  30          


Gly Thr Gly Lys Ser Thr Leu Ala Leu Gln Leu Gly Gln Arg Leu Gly 
        35                  40                  45              


Gly Glu Ile Val Ser Ala Asp Ser Met Gln Val Tyr Glu Gly Leu Asp 
    50                  55                  60                  


Ile Ile Thr Asn Lys Val Ser Ala Gln Glu Gln Arg Ile Cys Arg His 
65                  70                  75                  80  


His Met Ile Ser Phe Val Asp Pro Leu Val Thr Asn Tyr Thr Val Val 
                85                  90                  95      


Asp Phe Arg Asn Arg Ala Thr Ala Leu Ile Glu Asp Ile Phe Ala Arg 
            100                 105                 110         


Asp Lys Ile Pro Ile Val Val Gly Gly Thr Asn Tyr Tyr Ile Glu Ser 
        115                 120                 125             


Leu Leu Trp Lys Val Leu Val Asn Thr Lys Pro Gln Glu Met Gly Thr 
    130                 135                 140                 


Glu Lys Val Ile Asp Arg Lys Val Glu Leu Glu Lys Glu Asp Gly Leu 
145                 150                 155                 160 


Val Leu His Lys Arg Leu Ser Gln Val Asp Pro Glu Met Ala Ala Lys 
                165                 170                 175     


Leu His Pro His Asp Lys Arg Lys Val Ala Arg Ser Leu Gln Val Phe 
            180                 185                 190         


Glu Glu Thr Gly Ile Ser His Ser Glu Phe Leu His Arg Gln His Thr 
        195                 200                 205             


Glu Glu Gly Gly Gly Pro Leu Gly Gly Pro Leu Lys Phe Ser Asn Pro 
    210                 215                 220                 


Cys Ile Leu Trp Leu His Ala Asp Gln Ala Val Leu Asp Glu Arg Leu 
225                 230                 235                 240 


Asp Lys Arg Val Asp Asp Met Leu Ala Ala Gly Leu Leu Glu Glu Leu 
                245                 250                 255     


Arg Asp Phe His Arg Arg Tyr Asn Gln Lys Asn Val Ser Glu Asn Ser 
            260                 265                 270         


Gln Asp Tyr Gln His Gly Ile Phe Gln Ser Ile Gly Phe Lys Glu Phe 
        275                 280                 285             


His Glu Tyr Leu Ile Thr Glu Gly Lys Cys Thr Leu Glu Thr Ser Asn 
    290                 295                 300                 


Gln Leu Leu Lys Lys Gly Pro Gly Pro Ile Val Pro Pro Val Tyr Gly 
305                 310                 315                 320 


Leu Glu Val Ser Asp Val Ser Lys Trp Glu Glu Ser Val Leu Glu Pro 
                325                 330                 335     


Ala Leu Glu Ile Val Gln Ser Phe Ile Gln Gly His Lys Pro Thr Ala 
            340                 345                 350         


Thr Pro Ile Lys Met Pro Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr 
        355                 360                 365             


His Leu Cys Asp Leu Cys Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp 
    370                 375                 380                 


Ala Ala His Ile Lys Ser Lys Ser His Leu Asn Gln Leu Lys Lys Arg 
385                 390                 395                 400 


Arg Arg Leu Asp Ser Asp Ala Val Asn Thr Ile Glu Ser Gln Ser Val 
                405                 410                 415     


Ser Pro Asp His Asn Lys Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln 
            420                 425                 430         


Asn Asp Gln Glu Leu Lys Cys Ser Val 
        435                 440     


<210> 4681
<211> 205
<212> PRT
<213> Homo sapiens

<400> 4681
Met Ala Glu Pro Leu Gln Pro Asp Pro Gly Ala Ala Glu Asp Ala Ala 
1               5                   10                  15      


Ala Gln Ala Val Glu Thr Pro Gly Trp Lys Ala Pro Glu Asp Ala Gly 
            20                  25                  30          


Pro Gln Pro Gly Ser Tyr Glu Ile Arg His Tyr Gly Pro Ala Lys Trp 
        35                  40                  45              


Val Ser Thr Ser Val Glu Ser Met Asp Trp Asp Ser Ala Ile Gln Thr 
    50                  55                  60                  


Gly Phe Thr Lys Leu Asn Ser Tyr Ile Gln Gly Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Met Lys Ile Lys Met Thr Ala Pro Val Thr Ser Tyr Val Glu Pro Gly 
                85                  90                  95      


Ser Gly Pro Phe Ser Glu Ser Thr Ile Thr Ile Ser Leu Tyr Ile Pro 
            100                 105                 110         


Ser Glu Gln Gln Phe Asp Pro Pro Arg Pro Leu Glu Ser Asp Val Phe 
        115                 120                 125             


Ile Glu Asp Arg Ala Glu Met Thr Val Phe Val Arg Ser Phe Asp Gly 
    130                 135                 140                 


Phe Ser Ser Ala Gln Lys Asn Gln Glu Gln Leu Leu Thr Leu Ala Ser 
145                 150                 155                 160 


Ile Leu Arg Glu Asp Gly Lys Val Phe Asp Glu Lys Val Tyr Tyr Thr 
                165                 170                 175     


Ala Gly Tyr Asn Ser Pro Val Lys Leu Leu Asn Arg Asn Asn Glu Val 
            180                 185                 190         


Trp Leu Ile Gln Lys Asn Glu Pro Thr Lys Glu Asn Glu 
        195                 200                 205 


<210> 4682
<211> 207
<212> PRT
<213> Homo sapiens

<400> 4682
Met Ser Cys Thr Ile Glu Lys Ile Leu Thr Asp Ala Lys Thr Leu Leu 
1               5                   10                  15      


Glu Arg Leu Arg Glu His Asp Ala Ala Ala Glu Ser Leu Val Asp Gln 
            20                  25                  30          


Ser Ala Ala Leu His Arg Arg Val Ala Ala Met Arg Glu Ala Gly Thr 
        35                  40                  45              


Ala Leu Pro Asp Gln Tyr Gln Glu Asp Ala Ser Asp Met Lys Asp Met 
    50                  55                  60                  


Ser Lys Tyr Lys Pro His Ile Leu Leu Ser Gln Glu Asn Thr Gln Ile 
65                  70                  75                  80  


Arg Asp Leu Gln Gln Glu Asn Arg Glu Leu Trp Ile Ser Leu Glu Glu 
                85                  90                  95      


His Gln Asp Ala Leu Glu Leu Ile Met Ser Lys Tyr Arg Lys Gln Met 
            100                 105                 110         


Leu Gln Leu Met Val Ala Lys Lys Ala Val Asp Ala Glu Pro Val Leu 
        115                 120                 125             


Lys Ala His Gln Ser His Ser Ala Glu Ile Glu Ser Gln Ile Asp Arg 
    130                 135                 140                 


Ile Cys Glu Met Gly Glu Val Met Arg Lys Ala Val Gln Val Asp Asp 
145                 150                 155                 160 


Asp Gln Phe Cys Lys Ile Gln Glu Lys Leu Ala Gln Leu Glu Leu Glu 
                165                 170                 175     


Asn Lys Glu Leu Arg Glu Leu Leu Ser Ile Ser Ser Glu Ser Leu Gln 
            180                 185                 190         


Ala Arg Lys Glu Asn Ser Met Asp Thr Ala Ser Gln Ala Ile Lys 
        195                 200                 205         


<210> 4683
<211> 343
<212> PRT
<213> Homo sapiens

<400> 4683
Met Asn Ile His Arg Ser Thr Pro Ile Thr Ile Ala Arg Tyr Gly Arg 
1               5                   10                  15      


Ser Arg Asn Lys Thr Gln Asp Phe Glu Glu Leu Ser Ser Ile Arg Ser 
            20                  25                  30          


Ala Glu Pro Ser Gln Ser Phe Ser Pro Asn Leu Gly Ser Pro Ser Pro 
        35                  40                  45              


Pro Glu Thr Pro Asn Leu Ser His Cys Val Ser Cys Ile Gly Lys Tyr 
    50                  55                  60                  


Leu Leu Leu Glu Pro Leu Glu Gly Asp His Val Phe Arg Ala Val His 
65                  70                  75                  80  


Leu His Ser Gly Glu Glu Leu Val Cys Lys Val Phe Asp Ile Ser Cys 
                85                  90                  95      


Tyr Gln Glu Ser Leu Ala Pro Cys Phe Cys Leu Ser Ala His Ser Asn 
            100                 105                 110         


Ile Asn Gln Ile Thr Glu Ile Ile Leu Gly Glu Thr Lys Ala Tyr Val 
        115                 120                 125             


Phe Phe Glu Arg Ser Tyr Gly Asp Met His Ser Phe Val Arg Thr Cys 
    130                 135                 140                 


Lys Lys Leu Arg Glu Glu Glu Ala Ala Arg Leu Phe Tyr Gln Ile Ala 
145                 150                 155                 160 


Ser Ala Val Ala His Cys His Asp Gly Gly Leu Val Leu Arg Asp Leu 
                165                 170                 175     


Lys Leu Arg Lys Phe Ile Phe Lys Asp Glu Glu Arg Thr Arg Val Lys 
            180                 185                 190         


Leu Glu Ser Leu Glu Asp Ala Tyr Ile Leu Arg Gly Asp Asp Asp Ser 
        195                 200                 205             


Leu Ser Asp Lys His Gly Cys Pro Ala Tyr Val Ser Pro Glu Ile Leu 
    210                 215                 220                 


Asn Thr Ser Gly Ser Tyr Ser Gly Lys Ala Ala Asp Val Trp Ser Leu 
225                 230                 235                 240 


Gly Val Met Leu Tyr Thr Met Leu Val Gly Arg Tyr Pro Phe His Asp 
                245                 250                 255     


Ile Glu Pro Ser Ser Leu Phe Ser Lys Ile Arg Arg Gly Gln Phe Asn 
            260                 265                 270         


Ile Pro Glu Thr Leu Ser Pro Lys Ala Lys Cys Leu Ile Arg Ser Ile 
        275                 280                 285             


Leu Arg Arg Glu Pro Ser Glu Arg Leu Thr Ser Gln Glu Ile Leu Asp 
    290                 295                 300                 


His Pro Trp Phe Ser Thr Asp Phe Ser Val Ser Asn Ser Ala Tyr Gly 
305                 310                 315                 320 


Ala Lys Glu Val Ser Asp Gln Leu Val Pro Asp Val Asn Met Glu Glu 
                325                 330                 335     


Asn Leu Asp Pro Phe Phe Asn 
            340             


<210> 4684
<211> 1015
<212> PRT
<213> Homo sapiens

<400> 4684
Met Arg Arg Phe Leu Arg Pro Gly His Asp Pro Val Arg Glu Arg Leu 
1               5                   10                  15      


Lys Arg Asp Leu Phe Gln Phe Asn Lys Thr Val Glu His Gly Phe Pro 
            20                  25                  30          


His Gln Pro Ser Ala Leu Gly Tyr Ser Pro Ser Leu Arg Ile Leu Ala 
        35                  40                  45              


Ile Gly Thr Arg Ser Gly Ala Ile Lys Leu Tyr Gly Ala Pro Gly Val 
    50                  55                  60                  


Glu Phe Met Gly Leu His Gln Glu Asn Asn Ala Val Thr Gln Ile His 
65                  70                  75                  80  


Leu Leu Pro Gly Gln Cys Gln Leu Val Thr Leu Leu Asp Asp Asn Ser 
                85                  90                  95      


Leu His Leu Trp Ser Leu Lys Val Lys Gly Gly Ala Ser Glu Leu Gln 
            100                 105                 110         


Glu Asp Glu Ser Phe Thr Leu Arg Gly Pro Pro Gly Ala Ala Pro Ser 
        115                 120                 125             


Ala Thr Gln Ile Thr Val Val Leu Pro His Ser Ser Cys Glu Leu Leu 
    130                 135                 140                 


Tyr Leu Gly Thr Glu Ser Gly Asn Val Phe Val Val Gln Leu Pro Ala 
145                 150                 155                 160 


Phe Arg Ala Leu Glu Asp Arg Thr Ile Ser Ser Asp Ala Val Leu Gln 
                165                 170                 175     


Arg Leu Pro Glu Glu Ala Arg His Arg Arg Val Phe Glu Met Val Glu 
            180                 185                 190         


Ala Leu Gln Glu His Pro Arg Asp Pro Asn Gln Ile Leu Ile Gly Tyr 
        195                 200                 205             


Ser Arg Gly Leu Val Val Ile Trp Asp Leu Gln Gly Ser Arg Val Leu 
    210                 215                 220                 


Tyr His Phe Leu Ser Ser Gln Gln Leu Glu Asn Ile Trp Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Arg Leu Leu Val Ser Cys His Ser Asp Gly Ser Tyr Cys Gln 
                245                 250                 255     


Trp Pro Val Ser Ser Glu Ala Gln Gln Pro Glu Pro Leu Arg Ser Leu 
            260                 265                 270         


Val Pro Tyr Gly Pro Phe Pro Cys Lys Ala Ile Thr Arg Ile Leu Trp 
        275                 280                 285             


Leu Thr Thr Arg Gln Gly Leu Pro Phe Thr Ile Phe Gln Gly Gly Met 
    290                 295                 300                 


Pro Arg Ala Ser Tyr Gly Asp Arg His Cys Ile Ser Val Ile His Asp 
305                 310                 315                 320 


Gly Gln Gln Thr Ala Phe Asp Phe Thr Ser Arg Val Ile Gly Phe Thr 
                325                 330                 335     


Val Leu Thr Glu Ala Asp Pro Ala Ala Thr Phe Asp Asp Pro Tyr Ala 
            340                 345                 350         


Leu Val Val Leu Ala Glu Glu Glu Leu Val Val Ile Asp Leu Gln Thr 
        355                 360                 365             


Ala Gly Trp Pro Pro Val Gln Leu Pro Tyr Leu Ala Ser Leu His Cys 
    370                 375                 380                 


Ser Ala Ile Thr Cys Ser His His Val Ser Asn Ile Pro Leu Lys Leu 
385                 390                 395                 400 


Trp Glu Arg Ile Ile Ala Ala Gly Ser Arg Gln Asn Ala His Phe Ser 
                405                 410                 415     


Thr Met Glu Trp Pro Ile Asp Gly Gly Thr Ser Leu Thr Pro Ala Pro 
            420                 425                 430         


Pro Gln Arg Asp Leu Leu Leu Thr Gly His Glu Asp Gly Thr Val Arg 
        435                 440                 445             


Phe Trp Asp Ala Ser Gly Val Cys Leu Arg Leu Leu Tyr Lys Leu Ser 
    450                 455                 460                 


Thr Val Arg Val Phe Leu Thr Asp Thr Asp Pro Asn Glu Asn Phe Ser 
465                 470                 475                 480 


Ala Gln Gly Glu Asp Glu Trp Pro Pro Leu Arg Lys Val Gly Ser Phe 
                485                 490                 495     


Asp Pro Tyr Ser Asp Asp Pro Arg Leu Gly Ile Gln Lys Ile Phe Leu 
            500                 505                 510         


Cys Lys Tyr Ser Gly Tyr Leu Ala Val Ala Gly Thr Ala Gly Gln Val 
        515                 520                 525             


Leu Val Leu Glu Leu Asn Asp Glu Ala Ala Glu Gln Ala Val Glu Gln 
    530                 535                 540                 


Val Glu Ala Asp Leu Leu Gln Asp Gln Glu Gly Tyr Arg Trp Lys Gly 
545                 550                 555                 560 


His Glu Arg Leu Ala Ala Arg Ser Gly Pro Val Arg Phe Glu Pro Gly 
                565                 570                 575     


Phe Gln Pro Phe Val Leu Val Gln Cys Gln Pro Pro Ala Val Val Thr 
            580                 585                 590         


Ser Leu Ala Leu His Ser Glu Trp Arg Leu Val Ala Phe Gly Thr Ser 
        595                 600                 605             


His Gly Phe Gly Leu Phe Asp His Gln Gln Arg Arg Gln Val Phe Val 
    610                 615                 620                 


Lys Cys Thr Leu His Pro Ser Asp Gln Leu Ala Leu Glu Gly Pro Leu 
625                 630                 635                 640 


Ser Arg Val Lys Ser Leu Lys Lys Ser Leu Arg Gln Ser Phe Arg Arg 
                645                 650                 655     


Met Arg Arg Ser Arg Val Ser Ser Arg Lys Arg His Pro Ala Gly Pro 
            660                 665                 670         


Pro Gly Glu Ala Gln Glu Gly Ser Ala Lys Ala Glu Arg Pro Gly Leu 
        675                 680                 685             


Gln Asn Met Glu Leu Ala Pro Val Gln Arg Lys Ile Glu Ala Arg Ser 
    690                 695                 700                 


Ala Glu Asp Ser Phe Thr Gly Phe Val Arg Thr Leu Tyr Phe Ala Asp 
705                 710                 715                 720 


Thr Tyr Leu Lys Asp Ser Ser Arg His Cys Pro Ser Leu Trp Ala Gly 
                725                 730                 735     


Thr Asn Gly Gly Thr Ile Tyr Ala Phe Ser Leu Arg Val Pro Pro Ala 
            740                 745                 750         


Glu Arg Arg Met Asp Glu Pro Val Arg Ala Glu Gln Ala Lys Glu Ile 
        755                 760                 765             


Gln Leu Met His Arg Ala Pro Val Val Gly Ile Leu Val Leu Asp Gly 
    770                 775                 780                 


His Ser Val Pro Leu Pro Glu Pro Leu Glu Val Ala His Asp Leu Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Met Gln Gly Ser His Gln Leu Leu Val Val Ser Glu 
                805                 810                 815     


Glu Gln Phe Lys Val Phe Thr Leu Pro Lys Val Ser Ala Lys Leu Lys 
            820                 825                 830         


Leu Lys Leu Thr Ala Leu Glu Gly Ser Arg Val Arg Arg Val Ser Val 
        835                 840                 845             


Ala His Phe Gly Ser Arg Arg Ala Glu Asp Tyr Gly Glu His His Leu 
    850                 855                 860                 


Ala Val Leu Thr Asn Leu Gly Asp Ile Gln Val Val Ser Leu Pro Leu 
865                 870                 875                 880 


Leu Lys Pro Gln Val Arg Tyr Ser Cys Ile Arg Arg Glu Asp Val Ser 
                885                 890                 895     


Gly Ile Ala Ser Cys Val Phe Thr Lys Tyr Gly Gln Gly Phe Tyr Leu 
            900                 905                 910         


Ile Ser Pro Ser Glu Phe Glu Arg Phe Ser Leu Ser Thr Lys Trp Leu 
        915                 920                 925             


Val Glu Pro Arg Cys Leu Val Asp Ser Ala Glu Thr Lys Asn His Arg 
    930                 935                 940                 


Pro Gly Asn Gly Ala Gly Pro Lys Lys Ala Pro Ser Arg Ala Arg Asn 
945                 950                 955                 960 


Ser Gly Thr Gln Ser Asp Gly Glu Glu Lys Gln Pro Gly Leu Val Met 
                965                 970                 975     


Glu Arg Ala Leu Leu Ser Asp Glu Arg Ala Ala Thr Gly Val His Ile 
            980                 985                 990         


Glu Pro Pro Trp Gly Ala Ala Ser  Ala Met Ala Glu Gln  Ser Glu Trp 
        995                 1000                 1005             


Leu Ser  Val Gln Ala Ala Arg  
    1010                 1015 


<210> 4685
<211> 298
<212> PRT
<213> Homo sapiens

<400> 4685
Met Ala Ala Ala Glu Pro Ala Val Leu Ala Leu Pro Asn Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ala Gly Ala Pro Ser Gly Thr Val Pro Val Leu Phe Cys Phe 
            20                  25                  30          


Ser Val Phe Ala Arg Pro Ser Ser Val Pro His Gly Ala Gly Tyr Glu 
        35                  40                  45              


Leu Leu Ile Gln Lys Phe Leu Ser Leu Tyr Gly Asp Gln Ile Asp Met 
    50                  55                  60                  


His Arg Lys Phe Val Val Gln Leu Phe Ala Glu Glu Trp Gly Gln Tyr 
65                  70                  75                  80  


Val Asp Leu Pro Lys Gly Phe Ala Val Ser Glu Arg Cys Lys Val Arg 
                85                  90                  95      


Leu Val Pro Leu Gln Ile Gln Leu Thr Thr Leu Gly Asn Leu Thr Pro 
            100                 105                 110         


Ser Ser Thr Val Phe Phe Cys Cys Asp Met Gln Glu Arg Phe Arg Pro 
        115                 120                 125             


Ala Ile Lys Tyr Phe Gly Asp Ile Ile Ser Val Gly Gln Arg Leu Leu 
    130                 135                 140                 


Gln Gly Ala Arg Ile Leu Gly Ile Pro Val Ile Val Thr Glu Gln Tyr 
145                 150                 155                 160 


Pro Lys Gly Leu Gly Ser Thr Val Gln Glu Ile Asp Leu Thr Gly Val 
                165                 170                 175     


Lys Leu Val Leu Pro Lys Thr Lys Phe Ser Met Val Leu Pro Glu Val 
            180                 185                 190         


Glu Ala Ala Leu Ala Glu Ile Pro Gly Val Arg Ser Val Val Leu Phe 
        195                 200                 205             


Gly Val Glu Thr His Val Cys Ile Gln Gln Thr Ala Leu Glu Leu Val 
    210                 215                 220                 


Gly Arg Gly Val Glu Val His Ile Val Ala Asp Ala Thr Ser Ser Arg 
225                 230                 235                 240 


Ser Met Met Asp Arg Met Phe Ala Leu Glu Arg Leu Ala Arg Thr Gly 
                245                 250                 255     


Ile Ile Val Thr Thr Ser Glu Ala Val Leu Leu Gln Leu Val Ala Asp 
            260                 265                 270         


Lys Asp His Pro Lys Phe Lys Glu Ile Gln Asn Leu Ile Lys Ala Ser 
        275                 280                 285             


Ala Pro Glu Ser Gly Leu Leu Ser Lys Val 
    290                 295             


<210> 4686
<211> 812
<212> PRT
<213> Homo sapiens

<400> 4686
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Glu Ser Ile His Leu Gln Leu Ser Ser 
                85                  90                  95      


Phe Ser Ser Leu Gln Glu Glu Asp Lys Ser Arg Lys Asp Asp Ser Glu 
            100                 105                 110         


Arg Glu Lys Glu Lys Asp Lys Asn Lys Asp Lys Thr Ser Glu Lys Pro 
        115                 120                 125             


Lys Ile Arg Met Leu Ser Lys Asp Cys Ser Gln Glu Tyr Thr Asp Ser 
    130                 135                 140                 


Thr Gly Ile Asp Leu His Glu Phe Leu Ile Asn Thr Leu Lys Asn Asn 
145                 150                 155                 160 


Ser Arg Asp Arg Met Ile Leu Leu Lys Met Glu Gln Glu Ile Ile Asp 
                165                 170                 175     


Phe Ile Ala Asp Asn Asn Asn His Tyr Lys Lys Phe Pro Gln Met Ser 
            180                 185                 190         


Ser Tyr Gln Arg Met Leu Val His Arg Val Ala Ala Tyr Phe Gly Leu 
        195                 200                 205             


Asp His Asn Val Asp Gln Thr Gly Lys Ser Val Ile Ile Asn Lys Thr 
    210                 215                 220                 


Ser Ser Thr Arg Ile Pro Glu Gln Arg Phe Cys Glu His Leu Lys Asp 
225                 230                 235                 240 


Glu Lys Gly Glu Glu Ser Gln Lys Arg Phe Ile Leu Lys Arg Asp Asn 
                245                 250                 255     


Ser Ser Ile Asp Lys Glu Asp Asn Gln Gln Asn Arg Met His Pro Phe 
            260                 265                 270         


Arg Asp Asp Arg Arg Ser Lys Ser Ile Glu Glu Arg Glu Glu Glu Tyr 
        275                 280                 285             


Gln Arg Val Arg Glu Arg Ile Phe Ala His Asp Ser Val Cys Ser Gln 
    290                 295                 300                 


Glu Ser Leu Phe Val Glu Asn Ser Arg Leu Leu Glu Asp Ser Asn Ile 
305                 310                 315                 320 


Cys Asn Glu Thr Tyr Lys Lys Arg Gln Leu Phe Arg Gly Asn Arg Asp 
                325                 330                 335     


Gly Ser Gly Arg Thr Ser Gly Ser Arg Gln Ser Ser Ser Glu Asn Glu 
            340                 345                 350         


Leu Lys Trp Ser Asp His Gln Arg Ala Trp Ser Ser Thr Asp Ser Asp 
        355                 360                 365             


Ser Ser Asn Arg Asn Leu Lys Pro Ala Met Thr Lys Thr Ala Ser Phe 
    370                 375                 380                 


Gly Gly Ile Thr Val Leu Thr Arg Gly Asp Ser Thr Ser Ser Thr Arg 
385                 390                 395                 400 


Ser Thr Gly Lys Leu Ser Lys Ala Gly Ser Glu Ser Ser Ser Ser Ala 
                405                 410                 415     


Gly Ser Ser Gly Ser Leu Ser Arg Thr His Pro Pro Leu Gln Ser Thr 
            420                 425                 430         


Pro Leu Val Ser Gly Val Ala Ala Gly Ser Pro Gly Cys Val Pro Tyr 
        435                 440                 445             


Pro Glu Asn Gly Ile Gly Gly Gln Val Ala Pro Ser Ser Thr Ser Tyr 
    450                 455                 460                 


Ile Leu Leu Pro Leu Glu Ala Ala Thr Gly Ile Pro Pro Gly Ser Ile 
465                 470                 475                 480 


Leu Leu Asn Pro His Thr Gly Gln Pro Phe Val Asn Pro Asp Gly Thr 
                485                 490                 495     


Pro Ala Ile Tyr Asn Pro Pro Thr Ser Gln Gln Pro Leu Arg Ser Ala 
            500                 505                 510         


Met Val Gly Gln Ser Gln Gln Gln Pro Pro Gln Gln Gln Pro Ser Pro 
        515                 520                 525             


Gln Pro Gln Gln Gln Val Gln Pro Pro Gln Pro Gln Met Ala Gly Pro 
    530                 535                 540                 


Leu Val Thr Gln Arg Asp Asp Val Ala Thr Gln Phe Gly Gln Met Thr 
545                 550                 555                 560 


Leu Ser Arg Gln Ser Ser Gly Glu Thr Pro Glu Pro Pro Ser Gly Pro 
                565                 570                 575     


Val Tyr Pro Ser Ser Leu Met Pro Gln Pro Ala Gln Gln Pro Ser Tyr 
            580                 585                 590         


Val Ile Ala Ser Thr Gly Gln Gln Leu Pro Thr Gly Gly Phe Ser Gly 
        595                 600                 605             


Ser Gly Pro Pro Ile Ser Gln Gln Val Leu Gln Pro Pro Pro Ser Pro 
    610                 615                 620                 


Gln Gly Phe Val Gln Gln Pro Pro Pro Ala Gln Met Pro Val Tyr Tyr 
625                 630                 635                 640 


Tyr Pro Ser Gly Gln Tyr Pro Thr Ser Thr Thr Gln Gln Tyr Arg Pro 
                645                 650                 655     


Met Ala Pro Val Gln Tyr Asn Ala Gln Arg Ser Gln Gln Met Pro Gln 
            660                 665                 670         


Ala Ala Gln Gln Ala Gly Tyr Gln Pro Val Leu Ser Gly Gln Gln Gly 
        675                 680                 685             


Phe Gln Gly Leu Ile Gly Val Gln Gln Pro Pro Gln Ser Gln Asn Val 
    690                 695                 700                 


Ile Asn Asn Gln Gln Gly Thr Pro Val Gln Ser Val Met Val Ser Tyr 
705                 710                 715                 720 


Pro Thr Met Ser Ser Tyr Gln Val Pro Met Thr Gln Gly Ser Gln Gly 
                725                 730                 735     


Leu Pro Gln Gln Ser Tyr Gln Gln Pro Ile Met Leu Pro Asn Gln Ala 
            740                 745                 750         


Gly Gln Gly Ser Leu Pro Ala Thr Gly Met Pro Val Tyr Cys Asn Val 
        755                 760                 765             


Thr Pro Pro Thr Pro Gln Asn Asn Leu Arg Leu Ile Gly Pro His Cys 
    770                 775                 780                 


Pro Ser Ser Thr Val Pro Val Met Ser Ala Ser Cys Arg Thr Asn Cys 
785                 790                 795                 800 


Ala Ser Met Ser Asn Ala Gly Trp Gln Val Lys Phe 
                805                 810         


<210> 4687
<211> 396
<212> PRT
<213> Homo sapiens

<400> 4687
Met Thr Thr Leu Val Leu Asp Asn Gly Ala Tyr Asn Ala Lys Ile Gly 
1               5                   10                  15      


Tyr Ser His Glu Asn Val Ser Val Ile Pro Asn Cys Gln Phe Arg Ser 
            20                  25                  30          


Lys Thr Ala Arg Leu Lys Thr Phe Thr Ala Asn Gln Ile Asp Glu Ile 
        35                  40                  45              


Lys Asp Pro Ser Gly Leu Phe Tyr Ile Leu Pro Phe Gln Lys Gly Tyr 
    50                  55                  60                  


Leu Val Asn Trp Asp Val Gln Arg Gln Val Trp Asp Tyr Leu Phe Gly 
65                  70                  75                  80  


Lys Glu Met Tyr Gln Val Asp Phe Leu Asp Thr Asn Ile Ile Ile Thr 
                85                  90                  95      


Glu Pro Tyr Phe Asn Phe Thr Ser Ile Gln Glu Ser Met Asn Glu Ile 
            100                 105                 110         


Leu Phe Glu Glu Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Ala Gly 
        115                 120                 125             


Ala Leu Ser Ala His Arg Tyr Phe Arg Asp Asn Pro Ser Glu Leu Cys 
    130                 135                 140                 


Cys Ile Ile Val Asp Ser Gly Tyr Ser Phe Thr His Ile Val Pro Tyr 
145                 150                 155                 160 


Cys Arg Ser Lys Lys Lys Lys Glu Ala Ile Ile Arg Ile Asn Val Gly 
                165                 170                 175     


Gly Lys Leu Leu Thr Asn His Leu Lys Glu Ile Ile Ser Tyr Arg Gln 
            180                 185                 190         


Leu His Val Met Asp Glu Thr His Val Ile Asn Gln Val Lys Glu Asp 
        195                 200                 205             


Val Cys Tyr Val Ser Gln Asp Phe Tyr Arg Asp Met Asp Ile Ala Lys 
    210                 215                 220                 


Leu Lys Gly Glu Glu Asn Thr Val Met Ile Asp Tyr Val Leu Pro Asp 
225                 230                 235                 240 


Phe Ser Thr Ile Lys Lys Gly Phe Cys Lys Pro Arg Glu Glu Met Val 
                245                 250                 255     


Leu Ser Gly Lys Tyr Lys Ser Gly Glu Gln Ile Leu Arg Leu Ala Asn 
            260                 265                 270         


Glu Arg Phe Ala Val Pro Glu Ile Leu Phe Asn Pro Ser Asp Ile Gly 
        275                 280                 285             


Ile Gln Glu Met Gly Ile Pro Glu Ala Ile Val Tyr Ser Ile Gln Asn 
    290                 295                 300                 


Leu Pro Glu Glu Met Gln Pro His Phe Phe Lys Asn Ile Val Leu Thr 
305                 310                 315                 320 


Gly Gly Asn Ser Leu Phe Pro Gly Phe Arg Asp Arg Val Tyr Ser Glu 
                325                 330                 335     


Val Arg Cys Leu Thr Pro Thr Asp Tyr Asp Val Ser Val Val Leu Pro 
            340                 345                 350         


Glu Asn Pro Ile Thr Tyr Ala Trp Glu Gly Gly Lys Leu Ile Ser Glu 
        355                 360                 365             


Asn Asp Asp Phe Glu Asp Met Val Val Thr Arg Glu Asp Tyr Glu Glu 
    370                 375                 380                 


Asn Gly His Ser Val Cys Glu Glu Lys Phe Asp Ile 
385                 390                 395     


<210> 4688
<211> 334
<212> PRT
<213> Homo sapiens

<400> 4688
Met Glu Pro Gly Pro Thr Ala Ala Gln Arg Arg Cys Ser Leu Pro Pro 
1               5                   10                  15      


Trp Leu Pro Leu Gly Leu Leu Leu Trp Ser Gly Leu Ala Leu Gly Ala 
            20                  25                  30          


Leu Pro Phe Gly Ser Ser Pro His Arg Val Phe His Asp Leu Leu Ser 
        35                  40                  45              


Glu Gln Gln Leu Leu Glu Val Glu Asp Leu Ser Leu Ser Leu Leu Gln 
    50                  55                  60                  


Gly Gly Gly Leu Gly Pro Leu Ser Leu Pro Pro Asp Leu Pro Asp Leu 
65                  70                  75                  80  


Asp Pro Glu Cys Arg Glu Leu Leu Leu Asp Phe Ala Asn Ser Ser Ala 
                85                  90                  95      


Glu Leu Thr Gly Cys Leu Val Arg Ser Ala Arg Pro Val Arg Leu Cys 
            100                 105                 110         


Gln Thr Cys Tyr Pro Leu Phe Gln Gln Val Val Ser Lys Met Asp Asn 
        115                 120                 125             


Ile Ser Arg Ala Ala Gly Asn Thr Ser Glu Ser Gln Ser Cys Ala Arg 
    130                 135                 140                 


Ser Leu Leu Met Ala Asp Arg Met Gln Ile Val Val Ile Leu Ser Glu 
145                 150                 155                 160 


Phe Phe Asn Thr Thr Trp Gln Glu Ala Asn Cys Ala Asn Cys Leu Thr 
                165                 170                 175     


Asn Asn Ser Glu Glu Leu Ser Asn Ser Thr Val Tyr Phe Leu Asn Leu 
            180                 185                 190         


Phe Asn His Thr Leu Thr Cys Phe Glu His Asn Leu Gln Gly Asn Ala 
        195                 200                 205             


His Ser Leu Leu Gln Thr Lys Asn Tyr Ser Glu Val Cys Lys Asn Cys 
    210                 215                 220                 


Arg Glu Ala Tyr Lys Thr Leu Ser Ser Leu Tyr Ser Glu Met Gln Lys 
225                 230                 235                 240 


Met Asn Glu Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu Cys Ile 
                245                 250                 255     


Asp Val Glu Asp Ala Met Asn Ile Thr Arg Lys Leu Trp Ser Arg Thr 
            260                 265                 270         


Phe Asn Cys Ser Val Pro Cys Ser Asp Thr Val Pro Val Ile Ala Val 
        275                 280                 285             


Ser Val Phe Ile Leu Phe Leu Pro Val Val Phe Tyr Leu Ser Ser Phe 
    290                 295                 300                 


Leu His Ser Glu Gln Lys Lys Arg Lys Leu Ile Leu Pro Lys Arg Leu 
305                 310                 315                 320 


Lys Ser Ser Thr Ser Phe Ala Asn Ile Gln Glu Asn Ser Asn 
                325                 330                 


<210> 4689
<211> 723
<212> PRT
<213> Homo sapiens

<400> 4689
Met Ser Thr Ala Thr Gly Pro Glu Ala Ala Pro Lys Pro Ser Ala Lys 
1               5                   10                  15      


Ser Ile Tyr Glu Gln Arg Lys Arg Tyr Ser Thr Val Val Met Ala Asp 
            20                  25                  30          


Val Ser Gln Tyr Pro Val Asn His Leu Val Thr Phe Cys Leu Gly Glu 
        35                  40                  45              


Asp Asp Gly Val His Thr Val Glu Asp Ala Ser Arg Lys Leu Ala Val 
    50                  55                  60                  


Met Asp Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val 
65                  70                  75                  80  


Ser Pro Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Glu Glu Leu 
                85                  90                  95      


Glu Ser Tyr Pro Leu Gly Ala Ile Val Arg Cys Asp Ala Val Met Pro 
            100                 105                 110         


Pro Gly Arg Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu 
        115                 120                 125             


Arg Ala Gln Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala 
    130                 135                 140                 


Glu Leu Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser 
145                 150                 155                 160 


Gly Arg Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu 
                165                 170                 175     


Leu Gln Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg 
            180                 185                 190         


Arg Pro Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly 
        195                 200                 205             


Arg Gly Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln 
    210                 215                 220                 


Arg Pro Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro 
225                 230                 235                 240 


Asp Leu Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg 
                245                 250                 255     


Glu Val Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val 
            260                 265                 270         


Ser Arg Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Arg 
        275                 280                 285             


Glu Arg Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu 
    290                 295                 300                 


Thr Leu Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu 
305                 310                 315                 320 


Gln Lys Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn 
                325                 330                 335     


Ile Ala Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly Pro 
            340                 345                 350         


Leu Gln Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser 
        355                 360                 365             


Val Arg Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp 
    370                 375                 380                 


Asn Val Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser 
385                 390                 395                 400 


Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr 
                405                 410                 415     


Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln 
            420                 425                 430         


Ser Arg Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg 
        435                 440                 445             


Arg Arg Arg Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His Arg 
    450                 455                 460                 


Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly 
465                 470                 475                 480 


Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu 
                485                 490                 495     


Leu Ser Val Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser Arg 
            500                 505                 510         


Lys Trp Trp Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val Pro 
        515                 520                 525             


Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser Gln 
    530                 535                 540                 


Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala Pro 
545                 550                 555                 560 


Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg Pro 
                565                 570                 575     


Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly Leu Asp Pro Ser Glu Lys 
            580                 585                 590         


Glu Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala Arg 
        595                 600                 605             


Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro Arg 
    610                 615                 620                 


Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val Arg 
625                 630                 635                 640 


Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala Leu 
                645                 650                 655     


Gly Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Lys Glu Glu Leu 
            660                 665                 670         


Arg Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val Thr 
        675                 680                 685             


Val Gln Arg Ser Leu Leu Glu Asp Lys Glu Lys Val Ser Glu Leu Glu 
    690                 695                 700                 


Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly Glu Val Glu Met 
705                 710                 715                 720 


Glu Val Ile 
            


<210> 4690
<211> 1873
<212> PRT
<213> Homo sapiens

<400> 4690
Met Phe Ser Arg Arg Ser His Gly Asp Val Lys Lys Ser Thr Gln Lys 
1               5                   10                  15      


Val Leu Asp Pro Lys Lys Asp Val Leu Thr Arg Leu Lys His Leu Arg 
            20                  25                  30          


Ala Leu Leu Asp Asn Val Asp Ala Asn Asp Leu Lys Gln Phe Phe Glu 
        35                  40                  45              


Thr Asn Tyr Ser Gln Ile Tyr Phe Ile Phe Tyr Glu Asn Phe Ile Ala 
    50                  55                  60                  


Leu Glu Asn Ser Leu Lys Leu Lys Gly Asn Asn Lys Ser Gln Arg Glu 
65                  70                  75                  80  


Glu Leu Asp Ser Ile Leu Phe Leu Phe Glu Lys Ile Leu Gln Phe Leu 
                85                  90                  95      


Pro Glu Arg Ile Phe Phe Arg Trp His Tyr Gln Ser Ile Gly Ser Thr 
            100                 105                 110         


Leu Lys Lys Leu Leu His Thr Gly Asn Ser Ile Lys Ile Arg Cys Glu 
        115                 120                 125             


Gly Ile Arg Leu Phe Leu Leu Trp Leu Gln Ala Leu Gln Thr Asn Cys 
    130                 135                 140                 


Ala Glu Glu Gln Val Leu Ile Phe Ala Cys Leu Val Pro Gly Phe Pro 
145                 150                 155                 160 


Ala Val Met Ser Ser Arg Gly Pro Cys Thr Leu Glu Thr Leu Ile Asn 
                165                 170                 175     


Pro Ser Pro Ser Val Ala Asp Val Lys Ile Tyr Pro Glu Glu Ile Thr 
            180                 185                 190         


Pro Leu Leu Pro Ala Ile Ser Gly Glu Lys Ile Ala Glu Asp Gln Thr 
        195                 200                 205             


Cys Phe Phe Leu Gln Ile Leu Leu Lys Tyr Met Val Ile Gln Ala Ala 
    210                 215                 220                 


Ser Leu Glu Trp Lys Asn Lys Glu Asn Gln Asp Thr Gly Phe Lys Phe 
225                 230                 235                 240 


Leu Phe Thr Leu Phe Arg Lys Tyr Tyr Leu Pro His Leu Phe Pro Ser 
                245                 250                 255     


Phe Thr Lys Leu Thr Asn Ile Tyr Lys Pro Val Leu Asp Ile Pro His 
            260                 265                 270         


Leu Arg Pro Lys Pro Val Tyr Ile Thr Thr Thr Arg Asp Asn Glu Asn 
        275                 280                 285             


Ile Tyr Ser Thr Lys Ile Pro Tyr Met Ala Ala Arg Val Val Phe Ile 
    290                 295                 300                 


Lys Trp Ile Val Thr Phe Phe Leu Glu Lys Lys Tyr Leu Thr Ala Thr 
305                 310                 315                 320 


Gln Asn Thr Lys Asn Gly Val Asp Val Leu Pro Lys Ile Ile Gln Thr 
                325                 330                 335     


Val Gly Gly Gly Ala Val Gln Glu Arg Ala Pro Glu Leu Asp Gly Gly 
            340                 345                 350         


Gly Pro Thr Glu Gln Asp Lys Ser His Ser Asn Ser Ser Thr Leu Ser 
        355                 360                 365             


Asp Arg Arg Leu Ser Asn Ser Ser Leu Cys Ser Ile Glu Glu Glu His 
    370                 375                 380                 


Arg Met Val Tyr Glu Met Val Gln Arg Ile Leu Leu Ser Thr Arg Gly 
385                 390                 395                 400 


Tyr Val Asn Phe Val Asn Glu Val Phe His Gln Ala Phe Leu Leu Pro 
                405                 410                 415     


Ser Cys Glu Ile Ala Val Thr Arg Lys Val Val Gln Val Tyr Arg Lys 
            420                 425                 430         


Trp Ile Leu Gln Asp Lys Pro Val Phe Met Glu Glu Pro Asp Arg Lys 
        435                 440                 445             


Asp Val Ala Gln Glu Asp Ala Glu Lys Leu Gly Phe Ser Glu Thr Asp 
    450                 455                 460                 


Ser Lys Glu Ala Ser Ser Glu Ser Ser Gly His Lys Arg Ser Ser Ser 
465                 470                 475                 480 


Trp Gly Arg Thr Tyr Ser Phe Thr Ser Ala Met Ser Arg Gly Cys Val 
                485                 490                 495     


Thr Glu Glu Glu Asn Thr Asn Val Lys Ala Gly Val Gln Ala Leu Leu 
            500                 505                 510         


Gln Val Phe Leu Thr Asn Ser Ala Asn Ile Phe Leu Leu Glu Pro Cys 
        515                 520                 525             


Ala Glu Val Pro Val Leu Leu Lys Glu Gln Val Asp Ala Cys Lys Ala 
    530                 535                 540                 


Val Leu Ile Ile Phe Arg Arg Met Ile Met Glu Leu Thr Met Asn Lys 
545                 550                 555                 560 


Lys Thr Trp Glu Gln Met Leu Gln Ile Leu Leu Arg Ile Thr Glu Ala 
                565                 570                 575     


Val Met Gln Lys Pro Lys Asp Lys Gln Ile Lys Asp Leu Phe Ala Gln 
            580                 585                 590         


Ser Leu Ala Gly Leu Leu Phe Arg Thr Leu Met Val Ala Trp Ile Arg 
        595                 600                 605             


Ala Asn Leu Cys Val Tyr Ile Ser Arg Glu Leu Trp Asp Asp Phe Leu 
    610                 615                 620                 


Gly Val Leu Ser Ser Leu Thr Glu Trp Glu Glu Leu Ile Asn Glu Trp 
625                 630                 635                 640 


Ala Asn Ile Met Asp Ser Leu Thr Ala Val Leu Ala Arg Thr Val Tyr 
                645                 650                 655     


Gly Val Glu Met Thr Asn Leu Pro Leu Asp Lys Leu Ser Glu Gln Lys 
            660                 665                 670         


Glu Lys Lys Gln Arg Gly Lys Gly Cys Val Leu Asp Pro Gln Lys Gly 
        675                 680                 685             


Thr Thr Val Gly Arg Ser Phe Ser Leu Ser Trp Arg Ser His Pro Asp 
    690                 695                 700                 


Val Thr Glu Pro Met Arg Phe Arg Ser Ala Thr Thr Ser Gly Ala Pro 
705                 710                 715                 720 


Gly Val Glu Lys Ala Arg Asn Ile Val Arg Gln Lys Ala Thr Glu Val 
                725                 730                 735     


Glu Glu Cys Gln Gln Ser Glu Asn Ala Pro Ala Ala Gly Ser Gly His 
            740                 745                 750         


Leu Thr Val Gly Gln Gln Gln Gln Val Leu Arg Ser Ser Ser Thr Ser 
        755                 760                 765             


Asp Ile Pro Glu Pro Leu Cys Ser Asp Ser Ser Gln Gly Gln Lys Ala 
    770                 775                 780                 


Glu Asn Thr Gln Asn Ser Ser Ser Ser Glu Pro Gln Pro Ile Gln Glu 
785                 790                 795                 800 


Asn Lys Gly His Val Lys Arg Glu His Glu Gly Ile Thr Ile Leu Val 
                805                 810                 815     


Arg Arg Ser Ser Ser Pro Ala Glu Leu Asp Leu Lys Asp Asp Leu Gln 
            820                 825                 830         


Gln Thr Gln Gly Lys Cys Arg Glu Arg Gln Lys Ser Glu Ser Thr Asn 
        835                 840                 845             


Ser Asp Thr Thr Leu Gly Cys Thr Asn Glu Ala Glu Leu Ser Met Gly 
    850                 855                 860                 


Pro Trp Gln Thr Cys Glu Glu Asp Pro Glu Leu Asn Thr Pro Thr Asp 
865                 870                 875                 880 


Val Val Ala Asp Ala Asp Ala Arg His Trp Leu Gln Leu Ser Pro Thr 
                885                 890                 895     


Asp Ala Ser Asn Leu Thr Asp Ser Ser Glu Cys Leu Thr Asp Asp Cys 
            900                 905                 910         


Ser Ile Ile Ala Gly Gly Ser Leu Thr Gly Trp His Pro Asp Ser Ala 
        915                 920                 925             


Ala Val Leu Trp Arg Arg Val Leu Gly Ile Leu Gly Asp Val Asn Asn 
    930                 935                 940                 


Ile Gln Ser Pro Lys Ile His Ala Arg Val Phe Cys Tyr Leu Tyr Glu 
945                 950                 955                 960 


Leu Trp Tyr Lys Leu Ala Lys Ile Arg Asp Asn Leu Ala Ile Ser Leu 
                965                 970                 975     


Asp Asn Gln Ser Ser Pro Ser Pro Pro Val Leu Ile Pro Pro Leu Arg 
            980                 985                 990         


Met Phe Ala Ser Trp Leu Phe Lys  Ala Ala Thr Leu Pro  Asn Glu Tyr 
        995                 1000                 1005             


Lys Glu  Gly Lys Leu Gln Ala  Tyr Arg Leu Ile Cys  Ala Met Met 
    1010                 1015                 1020             


Thr Arg  Arg Gln Asp Val Leu  Pro Asn Ser Asp Phe  Leu Val His 
    1025                 1030                 1035             


Phe Tyr  Leu Val Met His Leu  Gly Leu Thr Ser Glu  Asp Gln Asp 
    1040                 1045                 1050             


Ile Leu  Asn Thr Ile Ile Arg  His Cys Pro Pro Arg  Phe Phe Ser 
    1055                 1060                 1065             


Leu Gly  Phe Pro Gly Phe Ser  Met Leu Val Gly Asp  Phe Ile Thr 
    1070                 1075                 1080             


Ala Ala  Ala Arg Val Leu Ser  Thr Asp Ile Leu Thr  Ala Pro Arg 
    1085                 1090                 1095             


Ser Glu  Ala Val Thr Val Leu  Gly Ser Leu Val Cys  Phe Pro Asn 
    1100                 1105                 1110             


Thr Tyr  Gln Glu Ile Pro Leu  Leu Gln Ser Val Pro  Glu Val Asn 
    1115                 1120                 1125             


Glu Ala  Ile Thr Gly Thr Glu  Asp Val Lys His Tyr  Leu Ile Asn 
    1130                 1135                 1140             


Ile Leu  Leu Lys Asn Ala Thr  Glu Glu Pro Asn Glu  Tyr Ala Arg 
    1145                 1150                 1155             


Cys Ile  Ala Val Cys Ser Leu  Gly Val Trp Ile Cys  Glu Glu Leu 
    1160                 1165                 1170             


Ala Gln  Cys Thr Ser His Pro  Gln Val Lys Glu Ala  Ile Asn Val 
    1175                 1180                 1185             


Ile Gly  Val Thr Leu Lys Phe  Pro Asn Lys Ile Val  Ala Gln Val 
    1190                 1195                 1200             


Ala Cys  Asp Val Leu Gln Leu  Leu Val Ser Tyr Trp  Glu Lys Leu 
    1205                 1210                 1215             


Gln Met  Phe Glu Thr Ser Leu  Pro Arg Lys Met Ala  Glu Ile Leu 
    1220                 1225                 1230             


Val Ala  Thr Val Ala Phe Leu  Leu Pro Ser Ala Glu  Tyr Ser Ser 
    1235                 1240                 1245             


Val Glu  Thr Asp Lys Lys Phe  Ile Val Ser Leu Leu  Leu Cys Leu 
    1250                 1255                 1260             


Leu Asp  Trp Cys Met Ala Leu  Pro Val Ser Val Leu  Leu His Pro 
    1265                 1270                 1275             


Val Ser  Thr Ala Val Leu Glu  Glu Gln His Ser Ala  Arg Ala Pro 
    1280                 1285                 1290             


Leu Leu  Asp Tyr Ile Tyr Arg  Val Leu His Cys Cys  Val Cys Gly 
    1295                 1300                 1305             


Ser Ser  Thr Tyr Thr Gln Gln  Ser His Tyr Ile Leu  Thr Leu Ala 
    1310                 1315                 1320             


Asp Leu  Ser Ser Thr Asp Tyr  Asp Pro Phe Leu Pro  Leu Ala Asn 
    1325                 1330                 1335             


Val Lys  Ser Ser Glu Pro Val  Gln Tyr His Ser Ser  Ala Glu Leu 
    1340                 1345                 1350             


Gly Asn  Leu Leu Thr Val Glu  Glu Glu Lys Lys Arg  Arg Ser Leu 
    1355                 1360                 1365             


Glu Leu  Ile Pro Leu Thr Ala  Arg Met Val Met Ala  His Leu Val 
    1370                 1375                 1380             


Asn His  Leu Gly His Tyr Pro  Leu Ser Gly Gly Pro  Ala Ile Leu 
    1385                 1390                 1395             


His Ser  Leu Val Ser Glu Asn  His Asp Asn Ala His  Val Glu Gly 
    1400                 1405                 1410             


Ser Glu  Leu Ser Phe Glu Val  Phe Arg Ser Pro Asn  Leu Gln Leu 
    1415                 1420                 1425             


Phe Val  Phe Asn Asp Ser Thr  Leu Ile Ser Tyr Leu  Gln Thr Pro 
    1430                 1435                 1440             


Thr Glu  Gly Pro Val Gly Gly  Ser Pro Val Gly Ser  Leu Ser Asp 
    1445                 1450                 1455             


Val Arg  Val Ile Val Arg Asp  Ile Ser Gly Lys Tyr  Ser Trp Asp 
    1460                 1465                 1470             


Gly Lys  Val Leu Tyr Gly Pro  Leu Glu Gly Cys Leu  Ala Pro Asn 
    1475                 1480                 1485             


Gly Arg  Asn Pro Ser Phe Leu  Ile Ser Ser Trp His  Arg Asp Thr 
    1490                 1495                 1500             


Phe Gly  Pro Gln Lys Asp Ser  Ser Gln Val Glu Glu  Gly Asp Asp 
    1505                 1510                 1515             


Val Leu  Asp Lys Leu Leu Glu  Asn Ile Gly His Thr  Ser Pro Glu 
    1520                 1525                 1530             


Cys Leu  Leu Pro Ser Gln Leu  Asn Leu Asn Glu Pro  Ser Leu Thr 
    1535                 1540                 1545             


Pro Cys  Gly Met Asn Tyr Asp  Gln Glu Lys Glu Ile  Ile Glu Val 
    1550                 1555                 1560             


Ile Leu  Arg Gln Asn Ala Gln  Glu Asp Glu Tyr Ile  Gln Ser His 
    1565                 1570                 1575             


Asn Phe  Asp Ser Ala Met Lys  Val Thr Ser Gln Gly  Gln Pro Ser 
    1580                 1585                 1590             


Pro Val  Glu Pro Arg Gly Pro  Phe Tyr Phe Cys Arg  Leu Leu Leu 
    1595                 1600                 1605             


Asp Asp  Leu Gly Met Asn Ser  Trp Asp Arg Arg Lys  Asn Phe His 
    1610                 1615                 1620             


Leu Leu  Lys Lys Asn Ser Lys  Leu Leu Arg Glu Leu  Lys Asn Leu 
    1625                 1630                 1635             


Asp Ser  Arg Gln Cys Arg Glu  Thr His Lys Ile Ala  Val Phe Tyr 
    1640                 1645                 1650             


Ile Ala  Glu Gly Gln Glu Asp  Lys Cys Ser Ile Leu  Ser Asn Glu 
    1655                 1660                 1665             


Arg Gly  Ser Gln Ala Tyr Glu  Asp Phe Val Ala Gly  Leu Gly Trp 
    1670                 1675                 1680             


Glu Val  Asp Leu Ser Thr His  Cys Gly Phe Met Gly  Gly Leu Gln 
    1685                 1690                 1695             


Arg Asn  Gly Ser Thr Gly Gln  Thr Ala Pro Tyr Tyr  Ala Thr Ser 
    1700                 1705                 1710             


Thr Val  Glu Val Ile Phe His  Val Ser Thr Arg Met  Pro Ser Asp 
    1715                 1720                 1725             


Ser Asp  Asp Ser Leu Thr Lys  Lys Leu Arg His Leu  Gly Asn Asp 
    1730                 1735                 1740             


Glu Val  His Ile Val Trp Ser  Glu His Ser Arg Asp  Tyr Arg Arg 
    1745                 1750                 1755             


Gly Ile  Ile Pro Thr Ala Phe  Gly Asp Val Ser Ile  Ile Ile Tyr 
    1760                 1765                 1770             


Pro Met  Lys Asn His Met Phe  Phe Ile Ala Ile Thr  Lys Lys Pro 
    1775                 1780                 1785             


Glu Val  Pro Phe Phe Gly Pro  Leu Phe Asp Gly Ala  Ile Val Ser 
    1790                 1795                 1800             


Gly Lys  Leu Leu Pro Ser Leu  Val Cys Ala Thr Cys  Ile Asn Ala 
    1805                 1810                 1815             


Ser Arg  Ala Val Lys Cys Leu  Ile Pro Leu Tyr Gln  Ser Phe Tyr 
    1820                 1825                 1830             


Glu Glu  Arg Ala Leu Tyr Leu  Glu Ala Ile Ile Gln  Asn His Arg 
    1835                 1840                 1845             


Glu Val  Met Thr Phe Glu Asp  Phe Ala Ala Gln Val  Phe Ser Pro 
    1850                 1855                 1860             


Ser Pro  Ser Tyr Ser Leu Ser  Gly Thr Asp 
    1865                 1870             


<210> 4691
<211> 582
<212> PRT
<213> Homo sapiens

<400> 4691
Met Gly Gly Ser Ser Pro Val Thr Ser Lys Ala Ile Val Asp Ala Asp 
1               5                   10                  15      


Gly Arg Ile Tyr Ile Arg Asn Trp Gln Gly Gly Ile Leu Ser Gly Gly 
            20                  25                  30          


Phe Glu Lys Asn Pro Lys Pro Ile Phe Thr Glu Gly Lys Asn Gln Leu 
        35                  40                  45              


Glu Ile Gln Asn Leu Gln Glu Asp Trp Asp His Phe Glu Pro Leu Leu 
    50                  55                  60                  


Ser Ser Leu Leu Arg Arg Met Pro Glu Leu Glu Thr Leu Glu Ile Met 
65                  70                  75                  80  


Lys Leu Val Asn Cys Pro Glu Thr Phe Thr Pro Asp Met Arg Cys Ile 
                85                  90                  95      


Met Gly Glu Ser Pro Ala Val Gln Gly Tyr Phe Val Leu Ala Gly Met 
            100                 105                 110         


Asn Ser Ala Gly Leu Ser Phe Gly Gly Gly Ala Gly Lys Tyr Leu Ala 
        115                 120                 125             


Glu Trp Met Val His Gly Tyr Pro Ser Glu Asn Val Trp Glu Leu Asp 
    130                 135                 140                 


Leu Lys Arg Phe Gly Ala Leu Gln Ser Ser Arg Thr Phe Leu Arg His 
145                 150                 155                 160 


Arg Val Met Glu Val Met Pro Leu Met Tyr Asp Leu Lys Val Pro Arg 
                165                 170                 175     


Trp Asp Phe Gln Thr Gly Arg Gln Leu Arg Thr Ser Pro Leu Tyr Asp 
            180                 185                 190         


Arg Leu Asp Ala Gln Gly Ala Arg Trp Met Glu Lys His Gly Phe Glu 
        195                 200                 205             


Arg Pro Lys Tyr Phe Val Pro Pro Asp Lys Asp Leu Leu Ala Leu Glu 
    210                 215                 220                 


Gln Ser Lys Thr Phe Tyr Lys Pro Asp Trp Phe Asp Ile Val Glu Ser 
225                 230                 235                 240 


Glu Val Lys Cys Cys Lys Glu Ala Val Cys Val Ile Asp Met Ser Ser 
                245                 250                 255     


Phe Thr Lys Phe Glu Ile Thr Ser Thr Gly Asp Gln Ala Leu Glu Val 
            260                 265                 270         


Leu Gln Tyr Leu Phe Ser Asn Asp Leu Asp Val Pro Val Gly His Ile 
        275                 280                 285             


Val His Thr Gly Met Leu Asn Glu Gly Gly Gly Tyr Glu Asn Asp Cys 
    290                 295                 300                 


Ser Ile Ala Arg Leu Asn Lys Arg Ser Phe Phe Met Ile Ser Pro Thr 
305                 310                 315                 320 


Asp Gln Gln Val His Cys Trp Ala Trp Leu Lys Lys His Met Pro Lys 
                325                 330                 335     


Asp Ser Asn Leu Leu Leu Glu Asp Val Thr Trp Lys Tyr Thr Ala Leu 
            340                 345                 350         


Asn Leu Ile Gly Pro Arg Ala Val Asp Val Leu Ser Glu Leu Ser Tyr 
        355                 360                 365             


Ala Pro Met Thr Pro Asp His Phe Pro Ser Leu Phe Cys Lys Glu Met 
    370                 375                 380                 


Ser Val Gly Tyr Ala Asn Gly Ile Arg Val Met Ser Met Thr His Thr 
385                 390                 395                 400 


Gly Glu Pro Gly Phe Met Leu Tyr Ile Pro Ile Glu Gly Met Asp Phe 
                405                 410                 415     


Ile Gly Arg Asp Ala Leu Leu Gln Gln Lys Gln Asn Gly Val Tyr Lys 
            420                 425                 430         


Arg Leu Thr Met Phe Ile Leu Asp Asp His Asp Ser Asp Leu Asp Leu 
        435                 440                 445             


Trp Pro Trp Trp Gly Glu Pro Ile Tyr Arg Asn Gly Gln Tyr Val Gly 
    450                 455                 460                 


Lys Thr Thr Ser Ser Ala Tyr Ser Tyr Ser Leu Glu Arg His Val Cys 
465                 470                 475                 480 


Leu Gly Phe Val His Asn Phe Ser Glu Asp Thr Gly Glu Glu Gln Val 
                485                 490                 495     


Val Thr Ala Asp Phe Ile Asn Arg Gly Glu Tyr Glu Ile Asp Ile Ala 
            500                 505                 510         


Gly Tyr Arg Phe Gln Ala Lys Ala Lys Leu Tyr Pro Val Ala Ser Leu 
        515                 520                 525             


Phe Thr Gln Lys Arg Arg Lys Asp Asp Met Glu Leu Ser Ala Phe Leu 
    530                 535                 540                 


Ala Leu Pro Pro Pro Pro Pro Asn Ile His Ser Gly Leu Phe Phe Pro 
545                 550                 555                 560 


Ser His Pro Ser Leu Ser Phe Ser Trp Trp Gln Glu Val Cys Leu Thr 
                565                 570                 575     


Gly Gln Lys Gln Ala Pro 
            580         


<210> 4692
<211> 706
<212> PRT
<213> Homo sapiens

<400> 4692
Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys 
            180                 185                 190         


Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His 
        195                 200                 205             


Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln 
    210                 215                 220                 


Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys 
225                 230                 235                 240 


Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys 
                245                 250                 255     


Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser 
            260                 265                 270         


Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile 
        275                 280                 285             


Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro 
    290                 295                 300                 


Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser 
305                 310                 315                 320 


Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu 
                325                 330                 335     


Arg Gln Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu Ile Glu 
            340                 345                 350         


Leu Gly Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile Asn Lys 
        355                 360                 365             


Ala Asn Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg Asn Phe 
    370                 375                 380                 


Asn Pro Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn Asp Asn 
385                 390                 395                 400 


Phe Gly Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser Leu Leu 
                405                 410                 415     


Met Gln His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu Ser Lys 
            420                 425                 430         


Asn Leu Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr Tyr Glu 
        435                 440                 445             


Ala Gly Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro 
    450                 455                 460                 


Gly Phe Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu 
465                 470                 475                 480 


Asn Thr Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln 
                485                 490                 495     


Ile Ile Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser 
            500                 505                 510         


Ile Ile Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg 
        515                 520                 525             


Leu Ile Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu 
    530                 535                 540                 


Gly Tyr His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys 
545                 550                 555                 560 


Gln Gly Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro 
                565                 570                 575     


Glu Ala Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala 
            580                 585                 590         


Lys Ile Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys 
        595                 600                 605             


Ala Leu Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys 
    610                 615                 620                 


Ser Thr Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser 
625                 630                 635                 640 


Ser Ile Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu 
                645                 650                 655     


His Val Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile 
            660                 665                 670         


Pro Ile Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr 
        675                 680                 685             


Ile Arg Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile 
    690                 695                 700                 


Gly His 
705     


<210> 4693
<211> 422
<212> PRT
<213> Homo sapiens

<400> 4693
Met Asn Ser Gly His Ser Phe Ser Gln Thr Pro Ser Ala Ser Phe His 
1               5                   10                  15      


Gly Ala Gly Gly Gly Trp Gly Arg Pro Arg Ser Phe Pro Arg Ala Pro 
            20                  25                  30          


Thr Val His Gly Gly Ala Gly Gly Ala Arg Ile Ser Leu Ser Phe Thr 
        35                  40                  45              


Thr Arg Ser Cys Pro Pro Pro Gly Gly Ser Trp Gly Ser Gly Arg Ser 
    50                  55                  60                  


Ser Pro Leu Leu Gly Gly Asn Gly Lys Ala Thr Met Gln Asn Leu Asn 
65                  70                  75                  80  


Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg Ala Leu Glu Glu Ala 
                85                  90                  95      


Asn Met Lys Leu Glu Ser Arg Ile Leu Lys Trp His Gln Gln Arg Asp 
            100                 105                 110         


Pro Gly Ser Lys Lys Asp Tyr Ser Gln Tyr Glu Glu Asn Ile Thr His 
        115                 120                 125             


Leu Gln Glu Gln Ile Val Asp Gly Lys Met Thr Asn Ala Gln Ile Ile 
    130                 135                 140                 


Leu Leu Ile Asp Asn Ala Arg Met Ala Val Asp Asp Phe Asn Leu Lys 
145                 150                 155                 160 


Tyr Glu Asn Glu His Ser Phe Lys Lys Asp Leu Glu Ile Glu Val Glu 
                165                 170                 175     


Gly Leu Arg Arg Thr Leu Asp Asn Leu Thr Ile Val Thr Thr Asp Leu 
            180                 185                 190         


Glu Gln Glu Val Glu Gly Met Arg Lys Glu Leu Ile Leu Met Lys Lys 
        195                 200                 205             


His His Glu Gln Glu Met Glu Lys His His Val Pro Ser Asp Phe Asn 
    210                 215                 220                 


Val Asn Val Lys Val Asp Thr Gly Pro Arg Glu Asp Leu Ile Lys Val 
225                 230                 235                 240 


Leu Glu Asp Met Arg Gln Glu Tyr Glu Leu Ile Ile Lys Lys Lys His 
                245                 250                 255     


Arg Asp Leu Asp Thr Trp Tyr Lys Glu Gln Ser Ala Ala Met Ser Gln 
            260                 265                 270         


Glu Ala Ala Ser Pro Ala Thr Val Gln Ser Arg Gln Gly Asp Ile His 
        275                 280                 285             


Glu Leu Lys Arg Thr Phe Gln Ala Leu Glu Ile Asp Leu Gln Thr Gln 
    290                 295                 300                 


Tyr Ser Thr Lys Ser Ala Leu Glu Asn Met Leu Ser Glu Thr Gln Ser 
305                 310                 315                 320 


Arg Tyr Ser Cys Lys Leu Gln Asp Met Gln Glu Ile Ile Ser His Tyr 
                325                 330                 335     


Glu Glu Glu Leu Thr Gln Leu Arg His Glu Leu Glu Arg Gln Asn Asn 
            340                 345                 350         


Glu Tyr Gln Val Leu Leu Gly Ile Lys Thr His Leu Glu Lys Glu Ile 
        355                 360                 365             


Thr Thr Tyr Arg Arg Leu Leu Glu Gly Glu Ser Glu Gly Thr Arg Glu 
    370                 375                 380                 


Glu Ser Lys Ser Ser Met Lys Val Ser Ala Thr Pro Lys Ile Lys Ala 
385                 390                 395                 400 


Ile Thr Gln Glu Thr Ile Asn Gly Arg Leu Val Leu Cys Gln Val Asn 
                405                 410                 415     


Glu Ile Gln Lys His Ala 
            420         


<210> 4694
<211> 191
<212> PRT
<213> Homo sapiens

<400> 4694
Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Ile Ala Arg Gly Phe Glu Arg Gly Leu Glu Pro Glu Lys Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Cys Gly Asp Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Thr Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Val Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ala 
                165                 170                 175     


Tyr Pro Glu Asp Ala Glu Asn Lys Glu Lys Glu Thr Ala Lys Ser 
            180                 185                 190     


<210> 4695
<211> 609
<212> PRT
<213> Homo sapiens

<400> 4695
Met Glu Gly Lys Pro Met Arg Arg Cys Thr Asn Ile Arg Pro Gly Glu 
1               5                   10                  15      


Thr Gly Met Asp Val Thr Ser Arg Cys Thr Leu Gly Asp Pro Asn Lys 
            20                  25                  30          


Leu Pro Glu Gly Val Pro Gln Pro Ala Arg Met Pro Tyr Ile Ser Asp 
        35                  40                  45              


Lys His Pro Arg Gln Thr Leu Glu Val Ile Asn Leu Leu Arg Lys His 
    50                  55                  60                  


Arg Glu Leu Cys Asp Val Val Leu Val Val Gly Ala Lys Lys Ile Tyr 
65                  70                  75                  80  


Ala His Arg Val Ile Leu Ser Ala Cys Ser Pro Tyr Phe Arg Ala Met 
                85                  90                  95      


Phe Thr Gly Glu Leu Ala Glu Ser Arg Gln Thr Glu Val Val Ile Arg 
            100                 105                 110         


Asp Ile Asp Glu Arg Ala Met Glu Leu Leu Ile Asp Phe Ala Tyr Thr 
        115                 120                 125             


Ser Gln Ile Thr Val Glu Glu Gly Asn Val Gln Thr Leu Leu Pro Ala 
    130                 135                 140                 


Ala Cys Leu Leu Gln Leu Ala Glu Ile Gln Glu Ala Cys Cys Glu Phe 
145                 150                 155                 160 


Leu Lys Arg Gln Leu Asp Pro Ser Asn Cys Leu Gly Ile Arg Ala Phe 
                165                 170                 175     


Ala Asp Thr His Ser Cys Arg Glu Leu Leu Arg Ile Ala Asp Lys Phe 
            180                 185                 190         


Thr Gln His Asn Phe Gln Glu Val Met Glu Ser Glu Glu Phe Met Leu 
        195                 200                 205             


Leu Pro Ala Asn Gln Leu Ile Asp Ile Ile Ser Ser Asp Glu Leu Asn 
    210                 215                 220                 


Val Arg Ser Glu Glu Gln Val Phe Asn Ala Val Met Ala Trp Val Lys 
225                 230                 235                 240 


Tyr Ser Ile Gln Glu Arg Arg Pro Gln Leu Pro Gln Val Leu Gln His 
                245                 250                 255     


Val Arg Leu Pro Leu Leu Ser Pro Lys Phe Leu Val Gly Thr Val Gly 
            260                 265                 270         


Ser Asp Pro Leu Ile Lys Ser Asp Glu Glu Cys Arg Asp Leu Val Asp 
        275                 280                 285             


Glu Ala Lys Asn Tyr Leu Leu Leu Pro Gln Glu Arg Pro Leu Met Gln 
    290                 295                 300                 


Gly Pro Arg Thr Arg Pro Arg Lys Pro Ile Arg Cys Gly Glu Val Leu 
305                 310                 315                 320 


Phe Ala Val Gly Gly Trp Cys Ser Gly Asp Ala Ile Ser Ser Val Glu 
                325                 330                 335     


Arg Tyr Asp Pro Gln Thr Asn Glu Trp Arg Met Val Ala Ser Met Ser 
            340                 345                 350         


Lys Arg Arg Cys Gly Val Gly Val Ser Val Leu Asp Asp Leu Leu Tyr 
        355                 360                 365             


Ala Val Gly Gly His Asp Gly Ser Ser Tyr Leu Asn Ser Val Glu Arg 
    370                 375                 380                 


Tyr Asp Pro Lys Thr Asn Gln Trp Ser Ser Asp Val Ala Pro Thr Ser 
385                 390                 395                 400 


Thr Cys Arg Thr Ser Val Gly Val Ala Val Leu Gly Gly Phe Leu Tyr 
                405                 410                 415     


Ala Val Gly Gly Gln Asp Gly Val Ser Cys Leu Asn Ile Val Glu Arg 
            420                 425                 430         


Tyr Asp Pro Lys Glu Asn Lys Trp Thr Arg Val Ala Ser Met Ser Thr 
        435                 440                 445             


Arg Arg Leu Gly Val Ala Val Ala Val Leu Gly Gly Phe Leu Tyr Ala 
    450                 455                 460                 


Val Gly Gly Ser Asp Gly Thr Ser Pro Leu Asn Thr Val Glu Arg Tyr 
465                 470                 475                 480 


Asn Pro Gln Glu Asn Arg Trp His Thr Ile Ala Pro Met Gly Thr Arg 
                485                 490                 495     


Arg Lys His Leu Gly Cys Ala Val Tyr Gln Asp Met Ile Tyr Ala Val 
            500                 505                 510         


Gly Gly Arg Asp Asp Thr Thr Glu Leu Ser Ser Ala Glu Arg Tyr Asn 
        515                 520                 525             


Pro Arg Thr Asn Gln Trp Ser Pro Val Val Ala Met Thr Ser Arg Arg 
    530                 535                 540                 


Ser Gly Val Gly Leu Ala Val Val Asn Gly Gln Leu Met Ala Val Gly 
545                 550                 555                 560 


Gly Phe Asp Gly Thr Thr Tyr Leu Lys Thr Ile Glu Val Phe Asp Pro 
                565                 570                 575     


Asp Ala Asn Thr Trp Arg Leu Tyr Gly Gly Met Asn Tyr Arg Arg Leu 
            580                 585                 590         


Gly Gly Gly Val Gly Val Ile Lys Met Thr His Cys Glu Ser His Ile 
        595                 600                 605             


Trp 
    


<210> 4696
<211> 350
<212> PRT
<213> Homo sapiens

<400> 4696
Met Phe Ile Lys Gly Arg Ala Pro Arg Ala Pro Pro Arg Glu Arg Arg 
1               5                   10                  15      


Arg Ala Thr Arg Gly Gly Leu Arg Gln Val Val Ala Pro Pro Arg Ala 
            20                  25                  30          


Leu Gly Ser Thr Ser Arg Pro His Phe Arg Arg Ala Ser Val Cys Arg 
        35                  40                  45              


Arg Arg Cys Arg Lys Ser Gly Gly Leu Leu Ala Ala Ser Arg Lys Met 
    50                  55                  60                  


Ala Ala Ala Ala Val Asn Gly Ala Ala Gly Phe Ser Ser Ser Gly Pro 
65                  70                  75                  80  


Ala Ala Thr Ser Gly Ala Val Leu Gln Ala Ala Thr Gly Met Tyr Glu 
                85                  90                  95      


Gln Leu Lys Gly Glu Trp Asn Arg Lys Ser Pro Asn Leu Ser Lys Cys 
            100                 105                 110         


Gly Glu Glu Leu Gly Arg Leu Lys Leu Val Leu Leu Glu Leu Asn Phe 
        115                 120                 125             


Leu Pro Thr Thr Gly Thr Lys Leu Thr Lys Gln Gln Leu Ile Leu Ala 
    130                 135                 140                 


Arg Asp Ile Leu Glu Ile Gly Ala Gln Trp Ser Ile Leu Arg Lys Asp 
145                 150                 155                 160 


Ile Pro Ser Phe Glu Arg Tyr Met Ala Gln Leu Lys Cys Tyr Tyr Phe 
                165                 170                 175     


Asp Tyr Lys Glu Gln Leu Pro Glu Ser Ala Tyr Met His Gln Leu Leu 
            180                 185                 190         


Gly Leu Asn Leu Leu Phe Leu Leu Ser Gln Asn Arg Val Ala Glu Phe 
        195                 200                 205             


His Thr Glu Leu Glu Arg Leu Pro Ala Lys Asp Ile Gln Thr Asn Val 
    210                 215                 220                 


Tyr Ile Lys His Pro Val Ser Leu Glu Gln Tyr Leu Met Glu Gly Ser 
225                 230                 235                 240 


Tyr Asn Lys Val Phe Leu Ala Lys Gly Asn Ile Pro Ala Glu Ser Tyr 
                245                 250                 255     


Thr Phe Phe Ile Asp Ile Leu Leu Asp Thr Ile Arg Asp Glu Ile Ala 
            260                 265                 270         


Gly Cys Ile Glu Lys Ala Tyr Glu Lys Ile Leu Phe Thr Glu Ala Thr 
        275                 280                 285             


Arg Ile Leu Phe Phe Asn Thr Pro Lys Lys Met Thr Asp Tyr Ala Lys 
    290                 295                 300                 


Lys Arg Gly Trp Val Leu Gly Pro Asn Asn Tyr Tyr Ser Phe Ala Ser 
305                 310                 315                 320 


Gln Gln Gln Lys Pro Glu Asp Thr Thr Ile Pro Ser Thr Glu Leu Ala 
                325                 330                 335     


Lys Gln Val Ile Glu Tyr Ala Arg Gln Leu Glu Met Ile Val 
            340                 345                 350 


<210> 4697
<211> 126
<212> PRT
<213> Homo sapiens

<400> 4697
Met Ser Ile Gly Val Pro Ile Lys Val Leu His Glu Ala Glu Gly His 
1               5                   10                  15      


Ile Val Thr Cys Glu Thr Asn Thr Gly Glu Val Tyr Arg Gly Lys Leu 
            20                  25                  30          


Ile Glu Ala Glu Asp Asn Met Asn Cys Gln Met Ser Asn Ile Thr Val 
        35                  40                  45              


Thr Tyr Arg Asp Gly Arg Val Ala Gln Leu Glu Gln Val Tyr Ile Arg 
    50                  55                  60                  


Gly Ser Lys Ile Arg Phe Leu Ile Leu Pro Asp Met Leu Lys Asn Ala 
65                  70                  75                  80  


Pro Met Leu Lys Ser Met Lys Asn Lys Asn Gln Gly Ser Gly Ala Gly 
                85                  90                  95      


Arg Gly Lys Ala Ala Ile Leu Lys Ala Gln Val Ala Ala Arg Gly Arg 
            100                 105                 110         


Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln Lys Arg Arg 
        115                 120                 125     


<210> 4698
<211> 970
<212> PRT
<213> Homo sapiens

<400> 4698
Met Leu Cys Phe Leu Asp Asp Gly Ala Gly Met Asp Pro Ser Asp Ala 
1               5                   10                  15      


Ala Ser Val Ile Gln Phe Gly Lys Ser Ala Lys Arg Thr Pro Glu Ser 
            20                  25                  30          


Thr Gln Ile Gly Gln Tyr Gly Asn Gly Leu Lys Ser Gly Ser Met Arg 
        35                  40                  45              


Ile Gly Lys Asp Phe Ile Leu Phe Thr Lys Lys Glu Asp Thr Met Thr 
    50                  55                  60                  


Cys Leu Phe Leu Ser Arg Thr Phe His Glu Glu Glu Gly Ile Asp Glu 
65                  70                  75                  80  


Val Ile Val Pro Leu Pro Thr Trp Asn Ala Arg Thr Arg Glu Pro Val 
                85                  90                  95      


Thr Asp Asn Val Glu Lys Phe Ala Ile Glu Thr Glu Leu Ile Tyr Lys 
            100                 105                 110         


Tyr Ser Pro Phe Arg Thr Glu Glu Glu Val Met Thr Gln Phe Met Lys 
        115                 120                 125             


Ile Pro Gly Asp Ser Gly Thr Leu Val Ile Ile Phe Asn Leu Lys Leu 
    130                 135                 140                 


Met Asp Asn Gly Glu Pro Glu Leu Asp Ile Ile Ser Asn Pro Arg Asp 
145                 150                 155                 160 


Ile Gln Met Ala Glu Thr Ser Pro Glu Gly Thr Lys Pro Glu Arg Arg 
                165                 170                 175     


Ser Phe Arg Ala Tyr Ala Ala Val Leu Tyr Ile Asp Pro Arg Met Arg 
            180                 185                 190         


Ile Phe Ile His Gly His Lys Val Gln Thr Lys Arg Leu Ser Cys Cys 
        195                 200                 205             


Leu Tyr Lys Pro Arg Met Tyr Lys Tyr Thr Ser Ser Arg Phe Lys Thr 
    210                 215                 220                 


Arg Ala Glu Gln Glu Val Lys Lys Ala Glu His Val Ala Arg Ile Ala 
225                 230                 235                 240 


Glu Glu Lys Ala Arg Glu Ala Glu Ser Lys Ala Arg Thr Leu Glu Val 
                245                 250                 255     


Arg Leu Gly Gly Asp Leu Thr Arg Asp Ser Arg Val Met Leu Arg Gln 
            260                 265                 270         


Val Gln Asn Arg Ala Ile Thr Leu Arg Arg Glu Ala Asp Val Lys Lys 
        275                 280                 285             


Arg Ile Lys Glu Ala Lys Gln Arg Ala Leu Lys Glu Pro Lys Glu Leu 
    290                 295                 300                 


Asn Phe Val Phe Gly Val Asn Ile Glu His Arg Asp Leu Asp Gly Met 
305                 310                 315                 320 


Phe Ile Tyr Asn Cys Ser Arg Leu Ile Lys Met Tyr Glu Lys Val Gly 
                325                 330                 335     


Pro Gln Leu Glu Gly Gly Met Ala Cys Gly Gly Val Val Gly Val Val 
            340                 345                 350         


Asp Val Pro Tyr Leu Val Leu Glu Pro Thr His Asn Lys Gln Asp Phe 
        355                 360                 365             


Ala Asp Ala Lys Glu Tyr Arg His Leu Leu Arg Ala Met Gly Glu His 
    370                 375                 380                 


Leu Ala Gln Tyr Trp Lys Asp Ile Ala Ile Ala Gln Arg Gly Ile Ile 
385                 390                 395                 400 


Lys Phe Trp Asp Glu Phe Gly Tyr Leu Ser Ala Asn Trp Asn Gln Pro 
                405                 410                 415     


Pro Ser Ser Glu Leu Arg Tyr Lys Arg Arg Arg Ala Met Glu Ile Pro 
            420                 425                 430         


Thr Thr Ile Gln Cys Asp Leu Cys Leu Lys Trp Arg Thr Leu Pro Phe 
        435                 440                 445             


Gln Leu Ser Ser Val Glu Lys Asp Tyr Pro Asp Thr Trp Val Cys Ser 
    450                 455                 460                 


Met Asn Pro Asp Pro Glu Gln Asp Arg Cys Glu Ala Ser Glu Gln Lys 
465                 470                 475                 480 


Gln Lys Val Pro Leu Gly Thr Phe Arg Lys Asp Met Lys Thr Gln Glu 
                485                 490                 495     


Glu Lys Gln Lys Gln Leu Thr Glu Lys Ile Arg Gln Gln Gln Glu Lys 
            500                 505                 510         


Leu Glu Ala Leu Gln Lys Thr Thr Pro Ile Arg Ser Gln Ala Asp Leu 
        515                 520                 525             


Lys Lys Leu Pro Leu Glu Val Thr Thr Arg Pro Ser Thr Glu Glu Pro 
    530                 535                 540                 


Val Arg Arg Pro Gln Arg Pro Arg Ser Pro Pro Leu Pro Ala Val Ile 
545                 550                 555                 560 


Arg Asn Ala Pro Ser Arg Pro Pro Ser Leu Pro Thr Pro Arg Pro Ala 
                565                 570                 575     


Ser Gln Pro Arg Lys Ala Pro Val Ile Ser Ser Thr Pro Lys Leu Pro 
            580                 585                 590         


Ala Leu Ala Ala Arg Glu Glu Ala Ser Thr Ser Arg Leu Leu Gln Pro 
        595                 600                 605             


Pro Glu Ala Pro Arg Lys Pro Ala Asn Thr Leu Val Lys Thr Ala Ser 
    610                 615                 620                 


Arg Pro Ala Pro Leu Val Gln Gln Leu Ser Pro Ser Leu Leu Pro Asn 
625                 630                 635                 640 


Ser Lys Ser Pro Arg Glu Val Pro Ser Pro Lys Val Ile Lys Thr Pro 
                645                 650                 655     


Val Val Lys Lys Thr Glu Ser Pro Ile Lys Leu Ser Pro Ala Thr Pro 
            660                 665                 670         


Ser Arg Lys Arg Ser Val Ala Val Ser Asp Glu Glu Glu Val Glu Glu 
        675                 680                 685             


Glu Ala Glu Arg Arg Lys Glu Arg Cys Lys Arg Gly Arg Phe Val Val 
    690                 695                 700                 


Lys Glu Glu Lys Lys Asp Ser Asn Glu Leu Ser Asp Ser Ala Gly Glu 
705                 710                 715                 720 


Glu Asp Ser Ala Asp Leu Lys Arg Ala Gln Lys Asp Lys Gly Leu His 
                725                 730                 735     


Val Glu Val Arg Val Asn Arg Glu Trp Tyr Thr Gly Arg Val Thr Ala 
            740                 745                 750         


Val Glu Val Gly Lys His Val Val Arg Trp Lys Val Lys Phe Asp Tyr 
        755                 760                 765             


Val Pro Thr Asp Thr Thr Pro Arg Asp Arg Trp Val Glu Lys Gly Ser 
    770                 775                 780                 


Glu Asp Val Arg Leu Met Lys Pro Pro Ser Pro Glu His Gln Ser Leu 
785                 790                 795                 800 


Asp Thr Gln Gln Glu Gly Gly Glu Glu Glu Val Gly Pro Val Ala Gln 
                805                 810                 815     


Gln Ala Ile Ala Val Ala Glu Pro Ser Thr Ser Glu Cys Leu Arg Ile 
            820                 825                 830         


Glu Pro Asp Thr Thr Ala Leu Ser Thr Asn His Glu Thr Ile Asp Leu 
        835                 840                 845             


Leu Val Gln Ile Leu Arg Asn Cys Leu Arg Tyr Phe Leu Pro Pro Ser 
    850                 855                 860                 


Phe Pro Ile Ser Lys Lys Gln Leu Ser Ala Met Asn Ser Asp Glu Leu 
865                 870                 875                 880 


Ile Ser Phe Pro Leu Lys Glu Tyr Phe Lys Gln Tyr Glu Val Gly Leu 
                885                 890                 895     


Gln Asn Leu Cys Asn Ser Tyr Gln Ser Arg Ala Asp Ser Arg Ala Lys 
            900                 905                 910         


Ala Ser Glu Glu Ser Leu Arg Thr Ser Glu Arg Lys Leu Arg Glu Thr 
        915                 920                 925             


Glu Glu Lys Leu Gln Lys Leu Arg Thr Asn Ile Val Ala Leu Leu Gln 
    930                 935                 940                 


Lys Val Gln Glu Asp Ile Asp Ile Asn Thr Asp Asp Glu Leu Asp Ala 
945                 950                 955                 960 


Tyr Ile Glu Asp Leu Ile Thr Lys Gly Asp 
                965                 970 


<210> 4699
<211> 863
<212> PRT
<213> Homo sapiens

<400> 4699
Met Ala Gly Pro Arg Gly Ala Leu Leu Ala Trp Cys Arg Arg Gln Cys 
1               5                   10                  15      


Glu Gly Tyr Arg Gly Val Glu Ile Arg Asp Leu Ser Ser Ser Phe Arg 
            20                  25                  30          


Asp Gly Leu Ala Phe Cys Ala Ile Leu His Arg His Arg Pro Asp Leu 
        35                  40                  45              


Leu Asp Phe Asp Ser Leu Ser Lys Asp Asn Val Phe Glu Asn Asn Arg 
    50                  55                  60                  


Leu Ala Phe Glu Val Ala Glu Lys Glu Leu Gly Ile Pro Ala Leu Leu 
65                  70                  75                  80  


Asp Pro Asn Asp Met Val Ser Met Ser Val Pro Asp Cys Leu Ser Ile 
                85                  90                  95      


Met Thr Tyr Val Ser Gln Tyr Tyr Asn His Phe Cys Ser Pro Gly Gln 
            100                 105                 110         


Ala Gly Val Ser Pro Pro Arg Lys Gly Leu Ala Pro Cys Ser Pro Pro 
        115                 120                 125             


Ser Val Ala Pro Thr Pro Val Glu Pro Glu Asp Val Ala Gln Gly Glu 
    130                 135                 140                 


Glu Leu Ser Ser Gly Ser Leu Ser Glu Gln Gly Thr Gly Gln Thr Pro 
145                 150                 155                 160 


Ser Ser Thr Cys Ala Ala Cys Gln Gln His Val His Leu Val Gln Arg 
                165                 170                 175     


Tyr Leu Ala Asp Gly Arg Leu Tyr His Arg His Cys Phe Arg Cys Arg 
            180                 185                 190         


Arg Cys Ser Ser Thr Leu Leu Pro Gly Ala Tyr Glu Asn Gly Pro Glu 
        195                 200                 205             


Glu Gly Thr Phe Val Cys Ala Glu His Cys Ala Arg Leu Gly Pro Gly 
    210                 215                 220                 


Thr Arg Ser Gly Thr Arg Pro Gly Pro Phe Ser Gln Pro Lys Gln Gln 
225                 230                 235                 240 


His Gln Gln Gln Leu Ala Glu Asp Ala Lys Asp Val Pro Gly Gly Gly 
                245                 250                 255     


Pro Ser Ser Ser Ala Pro Ala Gly Ala Glu Ala Asp Gly Pro Lys Ala 
            260                 265                 270         


Ser Pro Glu Ala Arg Pro Gln Ile Pro Thr Lys Pro Arg Val Pro Gly 
        275                 280                 285             


Lys Leu Gln Glu Leu Ala Ser Pro Pro Ala Gly Arg Pro Thr Pro Ala 
    290                 295                 300                 


Pro Arg Lys Ala Ser Glu Ser Thr Thr Pro Ala Pro Pro Thr Pro Arg 
305                 310                 315                 320 


Pro Arg Ser Ser Leu Gln Gln Glu Asn Leu Val Glu Gln Ala Gly Ser 
                325                 330                 335     


Ser Ser Leu Val Asn Gly Arg Leu His Glu Leu Pro Val Pro Lys Pro 
            340                 345                 350         


Arg Gly Thr Pro Lys Pro Ser Glu Gly Thr Pro Ala Pro Arg Lys Asp 
        355                 360                 365             


Pro Pro Trp Ile Thr Leu Val Gln Ala Glu Pro Lys Lys Lys Pro Ala 
    370                 375                 380                 


Pro Leu Pro Pro Ser Ser Ser Pro Gly Pro Pro Ser Gln Asp Ser Arg 
385                 390                 395                 400 


Gln Val Glu Asn Gly Gly Thr Glu Glu Val Ala Gln Pro Ser Pro Thr 
                405                 410                 415     


Ala Ser Leu Glu Ser Lys Pro Tyr Asn Pro Phe Glu Glu Glu Glu Glu 
            420                 425                 430         


Asp Lys Glu Glu Glu Ala Pro Ala Ala Pro Ser Leu Ala Thr Ser Pro 
        435                 440                 445             


Ala Leu Gly His Pro Glu Ser Thr Pro Lys Ser Leu His Pro Trp Tyr 
    450                 455                 460                 


Gly Ile Thr Pro Thr Ser Ser Pro Lys Thr Lys Lys Arg Pro Ala Pro 
465                 470                 475                 480 


Arg Ala Pro Ser Ala Ser Pro Leu Ala Leu His Ala Ser Arg Leu Ser 
                485                 490                 495     


His Ser Glu Pro Pro Ser Ala Thr Pro Ser Pro Ala Leu Ser Val Glu 
            500                 505                 510         


Ser Leu Ser Ser Glu Ser Ala Ser Gln Thr Ala Gly Ala Glu Leu Leu 
        515                 520                 525             


Glu Pro Pro Ala Val Pro Lys Ser Ser Ser Glu Pro Ala Val His Ala 
    530                 535                 540                 


Pro Gly Thr Pro Gly Asn Pro Val Ser Leu Ser Thr Asn Ser Ser Leu 
545                 550                 555                 560 


Ala Ser Ser Gly Glu Leu Val Glu Pro Arg Val Glu Gln Met Pro Gln 
                565                 570                 575     


Ala Ser Pro Gly Leu Ala Pro Arg Thr Arg Gly Ser Ser Gly Pro Gln 
            580                 585                 590         


Pro Ala Lys Pro Cys Ser Gly Ala Thr Pro Thr Pro Leu Leu Leu Val 
        595                 600                 605             


Gly Asp Arg Ser Pro Val Pro Ser Pro Gly Ser Ser Ser Pro Gln Leu 
    610                 615                 620                 


Gln Val Lys Ser Ser Cys Lys Glu Asn Pro Phe Asn Arg Lys Pro Ser 
625                 630                 635                 640 


Pro Ala Ala Ser Pro Ala Thr Lys Lys Ala Thr Lys Gly Ser Lys Pro 
                645                 650                 655     


Val Arg Pro Pro Ala Pro Gly His Gly Phe Pro Leu Ile Lys Arg Lys 
            660                 665                 670         


Val Gln Ala Asp Gln Tyr Ile Pro Glu Glu Asp Ile His Gly Glu Met 
        675                 680                 685             


Asp Thr Ile Glu Arg Arg Leu Asp Ala Leu Glu His Arg Gly Val Leu 
    690                 695                 700                 


Leu Glu Glu Lys Leu Arg Gly Gly Leu Asn Glu Gly Arg Glu Asp Asp 
705                 710                 715                 720 


Met Leu Val Asp Trp Phe Lys Leu Ile His Glu Lys His Leu Leu Val 
                725                 730                 735     


Arg Arg Glu Ser Glu Leu Ile Tyr Val Phe Lys Gln Gln Asn Leu Glu 
            740                 745                 750         


Gln Arg Gln Ala Asp Val Glu Tyr Glu Leu Arg Cys Leu Leu Asn Lys 
        755                 760                 765             


Pro Glu Lys Asp Trp Thr Glu Glu Asp Arg Ala Arg Glu Lys Val Leu 
    770                 775                 780                 


Met Gln Glu Leu Val Thr Leu Ile Glu Gln Arg Asn Ala Ile Ile Asn 
785                 790                 795                 800 


Cys Leu Asp Glu Asp Arg Gln Arg Glu Glu Glu Glu Asp Lys Met Leu 
                805                 810                 815     


Glu Ala Met Ile Lys Lys Lys Glu Phe Gln Arg Glu Ala Glu Pro Glu 
            820                 825                 830         


Gly Lys Lys Lys Gly Lys Phe Lys Thr Met Lys Met Leu Lys Leu Leu 
        835                 840                 845             


Gly Asn Lys Arg Asp Ala Lys Ser Lys Ser Pro Arg Asp Lys Ser 
    850                 855                 860             


<210> 4700
<211> 180
<212> PRT
<213> Homo sapiens

<400> 4700
Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn Thr Ala 
1               5                   10                  15      


Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln Leu Ala 
            20                  25                  30          


Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu 
        35                  40                  45              


Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp 
    50                  55                  60                  


Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn 
65                  70                  75                  80  


Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys 
                85                  90                  95      


Val Cys Phe Leu Ala Thr Gly Ala Gly Arg Glu Ser His Cys Ser Ile 
            100                 105                 110         


His Arg His Thr Val Val Lys Leu Ala His Thr Tyr Gln Ser Pro Leu 
        115                 120                 125             


Leu Tyr Cys Asp Leu Glu Val Glu Gly Phe Arg Ala Thr Met Ala Gln 
    130                 135                 140                 


Arg Leu Val Arg Val Leu Gln Ile Cys Ala Gly His Val Pro Gly Val 
145                 150                 155                 160 


Ser Ala Leu Asn Leu Leu Ser Leu Leu Arg Ser Ser Glu Gly Pro Ser 
                165                 170                 175     


Leu Glu Asp Leu 
            180 


<210> 4701
<211> 126
<212> PRT
<213> Homo sapiens

<400> 4701
Met Pro Phe Phe Gly Asn Thr Phe Ser Pro Lys Lys Thr Pro Pro Arg 
1               5                   10                  15      


Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Thr Arg 
            20                  25                  30          


Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Thr Met Asn Leu Ala 
        35                  40                  45              


Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala Glu Thr Gly 
    50                  55                  60                  


Val Ser Gly Gly Val Asp Arg Arg Glu Val Gln Arg Leu Arg Arg Arg 
65                  70                  75                  80  


Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp 
                85                  90                  95      


Ile Leu Leu Asp Met Leu Ser Glu Ser Thr Ala Glu Ser His Leu Met 
            100                 105                 110         


Glu Lys Glu Leu Asp Glu Leu Arg Ile Ser Arg Lys Arg Lys 
        115                 120                 125     


<210> 4702
<211> 966
<212> PRT
<213> Homo sapiens

<400> 4702
Met Phe Trp Lys Phe Asp Leu Asn Thr Thr Ser His Val Asp Lys Leu 
1               5                   10                  15      


Leu Asp Lys Glu His Val Thr Leu Gln Glu Leu Met Asp Glu Asp Asp 
            20                  25                  30          


Ile Leu Gln Glu Cys Lys Ala Gln Asn Gln Lys Leu Leu Asp Phe Leu 
        35                  40                  45              


Cys Arg Gln Gln Cys Met Glu Glu Leu Val Ser Leu Ile Thr Gln Asp 
    50                  55                  60                  


Pro Pro Leu Asp Met Glu Glu Lys Val Arg Phe Lys Tyr Pro Asn Thr 
65                  70                  75                  80  


Ala Cys Glu Leu Leu Thr Cys Asp Val Pro Gln Ile Ser Asp Arg Leu 
                85                  90                  95      


Gly Gly Asp Glu Ser Leu Leu Ser Leu Leu Tyr Asp Phe Leu Asp His 
            100                 105                 110         


Glu Pro Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Thr Ile 
        115                 120                 125             


Gly Asn Leu Ile Ala Arg Lys Thr Glu Gln Val Ile Thr Phe Leu Lys 
    130                 135                 140                 


Lys Lys Asp Lys Phe Ile Ser Leu Val Leu Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Leu Met Asp Leu Leu Leu Arg Leu Val Ser Cys Val Glu Pro Ala 
                165                 170                 175     


Gly Leu Arg Gln Asp Val Leu His Trp Leu Asn Glu Glu Lys Val Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Leu Ile His Pro Ser Gln Asp Glu Asp Arg Gln 
        195                 200                 205             


Ser Asn Ala Ser Gln Thr Leu Cys Asp Ile Val Arg Leu Gly Arg Asp 
    210                 215                 220                 


Gln Gly Ser Gln Leu Gln Glu Ala Leu Glu Pro Asp Pro Leu Leu Thr 
225                 230                 235                 240 


Ala Leu Glu Ser Gln Asp Cys Val Glu Gln Leu Leu Lys Asn Met Phe 
                245                 250                 255     


Asp Gly Asp Arg Thr Glu Ser Cys Leu Val Ser Gly Thr Gln Val Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Val Gly Thr Glu Gly Leu Val Asp 
        275                 280                 285             


Ser Phe Ser Gln Gly Leu Glu Arg Ser Tyr Ala Val Ser Ser Ser Val 
    290                 295                 300                 


Leu His Gly Ile Glu Pro Arg Leu Lys Asp Phe His Gln Leu Leu Leu 
305                 310                 315                 320 


Asn Pro Pro Lys Lys Lys Ala Ile Leu Thr Thr Ile Gly Val Leu Glu 
                325                 330                 335     


Glu Pro Leu Gly Asn Ala Arg Leu His Gly Ala Arg Leu Met Ala Ala 
            340                 345                 350         


Leu Leu His Thr Asn Thr Pro Ser Ile Asn Gln Glu Leu Cys Arg Leu 
        355                 360                 365             


Asn Thr Met Asp Leu Leu Leu Asp Leu Phe Phe Lys Tyr Thr Trp Asn 
    370                 375                 380                 


Asn Phe Leu His Phe Gln Val Glu Leu Cys Ile Ala Ala Ile Leu Ser 
385                 390                 395                 400 


His Ala Ala Arg Glu Glu Arg Thr Glu Ala Ser Gly Ser Glu Ser Arg 
                405                 410                 415     


Val Glu Pro Pro His Glu Asn Gly Asn Arg Ser Leu Glu Thr Pro Gln 
            420                 425                 430         


Pro Ala Ala Ser Leu Pro Asp Asn Thr Met Val Thr His Leu Phe Gln 
        435                 440                 445             


Lys Cys Cys Leu Val Gln Arg Ile Leu Glu Ala Trp Glu Ala Asn Asp 
    450                 455                 460                 


His Thr Gln Ala Ala Gly Gly Met Arg Arg Gly Asn Met Gly His Leu 
465                 470                 475                 480 


Thr Arg Ile Ala Asn Ala Val Val Gln Asn Leu Glu Arg Gly Pro Val 
                485                 490                 495     


Gln Thr His Ile Ser Glu Val Ile Arg Gly Leu Pro Ala Asp Cys Arg 
            500                 505                 510         


Gly Arg Trp Glu Ser Phe Val Glu Glu Thr Leu Thr Glu Thr Asn Arg 
        515                 520                 525             


Arg Asn Thr Val Asp Leu Val Ser Thr His His Leu His Ser Ser Ser 
    530                 535                 540                 


Glu Asp Glu Asp Ile Glu Gly Ala Phe Pro Asn Glu Leu Ser Leu Gln 
545                 550                 555                 560 


Gln Ala Phe Ser Asp Tyr Gln Ile Gln Gln Met Thr Ala Asn Phe Val 
                565                 570                 575     


Asp Gln Phe Gly Phe Asn Asp Glu Glu Phe Ala Asp Gln Asp Asp Asn 
            580                 585                 590         


Ile Asn Ala Pro Phe Asp Arg Ile Ala Glu Ile Asn Phe Asn Ile Asp 
        595                 600                 605             


Ala Asp Glu Asp Ser Pro Ser Ala Ala Leu Phe Glu Ala Cys Cys Ser 
    610                 615                 620                 


Asp Arg Ile Gln Pro Phe Asp Asp Asp Glu Asp Glu Asp Ile Trp Glu 
625                 630                 635                 640 


Asp Ser Asp Thr Arg Cys Ala Ala Arg Val Met Ala Arg Pro Arg Phe 
                645                 650                 655     


Gly Ala Pro His Ala Ser Glu Ser Cys Ser Lys Asn Gly Pro Glu Arg 
            660                 665                 670         


Gly Gly Gln Asp Gly Lys Ala Ser Leu Glu Ala His Arg Asp Ala Pro 
        675                 680                 685             


Gly Ala Gly Ala Pro Pro Ala Pro Gly Lys Lys Glu Ala Pro Pro Val 
    690                 695                 700                 


Glu Gly Asp Ser Glu Gly Ala Met Trp Thr Ala Val Phe Asp Glu Pro 
705                 710                 715                 720 


Ala Asn Ser Thr Pro Thr Ala Pro Gly Val Val Arg Asp Val Gly Ser 
                725                 730                 735     


Ser Val Trp Ala Ala Gly Thr Ser Ala Pro Glu Glu Lys Gly Trp Ala 
            740                 745                 750         


Lys Phe Thr Asp Phe Gln Pro Phe Cys Cys Ser Glu Ser Gly Pro Arg 
        755                 760                 765             


Cys Ser Ser Pro Val Asp Thr Glu Cys Ser His Ala Glu Gly Ser Arg 
    770                 775                 780                 


Ser Gln Gly Pro Glu Lys Ala Ser Gln Ala Ser Tyr Phe Ala Val Ser 
785                 790                 795                 800 


Pro Ala Ser Pro Cys Ala Trp Asn Val Cys Val Thr Arg Lys Ala Pro 
                805                 810                 815     


Leu Leu Ala Ser Asp Ser Ser Ser Ser Gly Gly Ser His Ser Glu Asp 
            820                 825                 830         


Gly Asp Gln Lys Ala Ala Ser Ala Met Asp Ala Val Ser Arg Gly Pro 
        835                 840                 845             


Gly Arg Glu Ala Pro Pro Leu Pro Thr Val Ala Arg Thr Glu Glu Ala 
    850                 855                 860                 


Val Gly Arg Val Gly Cys Ala Asp Ser Arg Leu Leu Ser Pro Ala Cys 
865                 870                 875                 880 


Pro Ala Pro Lys Glu Val Thr Ala Ala Pro Ala Val Ala Val Pro Pro 
                885                 890                 895     


Glu Ala Thr Val Ala Ile Thr Thr Ala Leu Ser Lys Ala Gly Pro Ala 
            900                 905                 910         


Ile Pro Thr Pro Ala Val Ser Ser Ala Leu Ala Val Ala Val Pro Leu 
        915                 920                 925             


Gly Pro Ile Met Ala Val Thr Ala Ala Pro Ala Met Val Ala Thr Leu 
    930                 935                 940                 


Gly Thr Val Thr Lys Asp Gly Lys Thr Asp Ala Pro Pro Glu Gly Ala 
945                 950                 955                 960 


Ala Leu Asn Gly Pro Val 
                965     


<210> 4703
<211> 108
<212> PRT
<213> Homo sapiens

<400> 4703
Met Ala Ala Ala Met Asp Val Asp Thr Pro Ser Gly Thr Asn Ser Gly 
1               5                   10                  15      


Ala Gly Lys Lys Arg Phe Glu Val Lys Lys Trp Asn Ala Val Ala Leu 
            20                  25                  30          


Trp Ala Trp Asp Ile Val Val Asp Asn Cys Ala Ile Cys Arg Asn His 
        35                  40                  45              


Ile Met Asp Leu Cys Ile Glu Cys Gln Ala Asn Gln Ala Ser Ala Thr 
    50                  55                  60                  


Ser Glu Glu Cys Thr Val Ala Trp Gly Val Cys Asn His Ala Phe His 
65                  70                  75                  80  


Phe His Cys Ile Ser Arg Trp Leu Lys Thr Arg Gln Val Cys Pro Leu 
                85                  90                  95      


Asp Asn Arg Glu Trp Glu Phe Gln Lys Tyr Gly His 
            100                 105             


<210> 4704
<211> 669
<212> PRT
<213> Homo sapiens

<400> 4704
Met Gly Thr Ala Leu Val Tyr His Glu Asp Met Thr Ala Thr Arg Leu 
1               5                   10                  15      


Leu Trp Asp Asp Pro Glu Cys Glu Ile Glu Arg Pro Glu Arg Leu Thr 
            20                  25                  30          


Ala Ala Leu Asp Arg Leu Arg Gln Arg Gly Leu Glu Gln Arg Cys Leu 
        35                  40                  45              


Arg Leu Ser Ala Arg Glu Ala Ser Glu Glu Glu Leu Gly Leu Val His 
    50                  55                  60                  


Ser Pro Glu Tyr Val Ser Leu Val Arg Glu Thr Gln Val Leu Gly Lys 
65                  70                  75                  80  


Glu Glu Leu Gln Ala Leu Ser Gly Gln Phe Asp Ala Ile Tyr Phe His 
                85                  90                  95      


Pro Ser Thr Phe His Cys Ala Arg Leu Ala Ala Gly Ala Gly Leu Gln 
            100                 105                 110         


Leu Val Asp Ala Val Leu Thr Gly Ala Val Gln Asn Gly Leu Ala Leu 
        115                 120                 125             


Val Arg Pro Pro Gly His His Gly Gln Arg Ala Ala Ala Asn Gly Phe 
    130                 135                 140                 


Cys Val Phe Asn Asn Val Ala Ile Ala Ala Ala His Ala Lys Gln Lys 
145                 150                 155                 160 


His Gly Leu His Arg Ile Leu Val Val Asp Trp Asp Val His His Gly 
                165                 170                 175     


Gln Gly Ile Gln Tyr Leu Phe Glu Asp Asp Pro Ser Val Leu Tyr Phe 
            180                 185                 190         


Ser Trp His Arg Tyr Glu His Gly Arg Phe Trp Pro Phe Leu Arg Glu 
        195                 200                 205             


Ser Asp Ala Asp Ala Val Gly Arg Gly Gln Gly Leu Gly Phe Thr Val 
    210                 215                 220                 


Asn Leu Pro Trp Asn Gln Val Gly Met Gly Asn Ala Asp Tyr Val Ala 
225                 230                 235                 240 


Ala Phe Leu His Leu Leu Leu Pro Leu Ala Phe Glu Phe Asp Pro Glu 
                245                 250                 255     


Leu Val Leu Val Ser Ala Gly Phe Asp Ser Ala Ile Gly Asp Pro Glu 
            260                 265                 270         


Gly Gln Met Gln Ala Thr Pro Glu Cys Phe Ala His Leu Thr Gln Leu 
        275                 280                 285             


Leu Gln Val Leu Ala Gly Gly Arg Val Cys Ala Val Leu Glu Gly Gly 
    290                 295                 300                 


Tyr His Leu Glu Ser Leu Ala Glu Ser Val Cys Met Thr Val Gln Thr 
305                 310                 315                 320 


Leu Leu Gly Asp Pro Ala Pro Pro Leu Ser Gly Pro Met Ala Pro Cys 
                325                 330                 335     


Gln Ser Ala Leu Glu Ser Ile Gln Ser Ala Arg Ala Ala Gln Ala Pro 
            340                 345                 350         


His Trp Lys Ser Leu Gln Gln Gln Asp Val Thr Ala Val Pro Met Ser 
        355                 360                 365             


Pro Ser Ser His Ser Pro Glu Gly Arg Pro Pro Pro Leu Leu Pro Gly 
    370                 375                 380                 


Gly Pro Val Cys Lys Ala Ala Ala Ser Ala Pro Ser Ser Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Cys Leu Cys Pro Ala Pro Ser Val Arg Thr Ala Val Ala Leu 
                405                 410                 415     


Thr Thr Pro Asp Ile Thr Leu Val Leu Pro Pro Asp Val Ile Gln Gln 
            420                 425                 430         


Glu Ala Ser Ala Leu Arg Glu Glu Thr Glu Ala Trp Ala Arg Pro His 
        435                 440                 445             


Glu Ser Leu Ala Arg Glu Glu Ala Leu Thr Ala Leu Gly Lys Leu Leu 
    450                 455                 460                 


Tyr Leu Leu Asp Gly Met Leu Asp Gly Gln Val Asn Ser Gly Ile Ala 
465                 470                 475                 480 


Ala Thr Pro Ala Ser Ala Ala Ala Ala Thr Leu Asp Val Ala Val Arg 
                485                 490                 495     


Arg Gly Leu Ser His Gly Ala Gln Arg Leu Leu Cys Val Ala Leu Gly 
            500                 505                 510         


Gln Leu Asp Arg Pro Pro Asp Leu Ala His Asp Gly Arg Ser Leu Trp 
        515                 520                 525             


Leu Asn Ile Arg Gly Lys Glu Ala Ala Ala Leu Ser Met Phe His Val 
    530                 535                 540                 


Ser Thr Pro Leu Pro Val Met Thr Gly Gly Phe Leu Ser Cys Ile Leu 
545                 550                 555                 560 


Gly Leu Val Leu Pro Leu Ala Tyr Gly Phe Gln Pro Asp Leu Val Leu 
                565                 570                 575     


Val Ala Leu Gly Pro Gly His Gly Leu Gln Gly Pro His Ala Ala Leu 
            580                 585                 590         


Leu Ala Ala Met Leu Arg Gly Leu Ala Gly Gly Arg Val Leu Ala Leu 
        595                 600                 605             


Leu Glu Glu Asn Ser Thr Pro Gln Leu Ala Gly Ile Leu Ala Arg Val 
    610                 615                 620                 


Leu Asn Gly Glu Ala Pro Pro Ser Leu Gly Pro Ser Ser Val Ala Ser 
625                 630                 635                 640 


Pro Glu Asp Val Gln Ala Leu Met Tyr Leu Arg Gly Gln Leu Glu Pro 
                645                 650                 655     


Gln Trp Lys Met Leu Gln Cys His Pro His Leu Val Ala 
            660                 665                 


<210> 4705
<211> 576
<212> PRT
<213> Homo sapiens

<400> 4705
Met Arg Gly Pro Asn Ser Gly Thr Glu Lys Gly Arg Leu Val Ile Pro 
1               5                   10                  15      


Glu Lys Gln Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro Arg 
            20                  25                  30          


Phe Lys Arg Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly Pro 
        35                  40                  45              


Gln Thr Arg Ser Asp Leu Leu Leu Ser Gly Arg Ala Phe Leu Leu Pro 
    50                  55                  60                  


Leu Asn Gln Glu Asp Asn Thr Asn Leu Ala Arg Val Leu Thr Asn His 
65                  70                  75                  80  


Ile His Thr Gly His His Ser Ser Met Phe Trp Met Arg Val Pro Leu 
                85                  90                  95      


Val Ala Pro Glu Asp Leu Arg Asp Asp Ile Ile Glu Asn Ala Pro Thr 
            100                 105                 110         


Thr His Thr Glu Glu Tyr Ser Gly Glu Glu Lys Thr Trp Met Trp Trp 
        115                 120                 125             


His Asn Phe Arg Thr Leu Cys Asp Tyr Ser Lys Arg Ile Ala Val Ala 
    130                 135                 140                 


Leu Glu Ile Gly Ala Asp Leu Pro Ser Asn His Val Ile Asp Arg Trp 
145                 150                 155                 160 


Leu Gly Glu Pro Ile Lys Ala Ala Ile Leu Pro Thr Ser Ile Phe Leu 
                165                 170                 175     


Thr Asn Lys Lys Gly Phe Pro Val Leu Ser Lys Met His Gln Arg Leu 
            180                 185                 190         


Ile Phe Arg Leu Leu Lys Leu Glu Val Gln Phe Ile Ile Thr Gly Thr 
        195                 200                 205             


Asn His His Ser Glu Lys Glu Phe Cys Ser Tyr Leu Gln Tyr Leu Glu 
    210                 215                 220                 


Tyr Leu Ser Gln Asn Arg Pro Pro Pro Asn Ala Tyr Glu Leu Phe Ala 
225                 230                 235                 240 


Lys Gly Tyr Glu Asp Tyr Leu Gln Ser Pro Leu Gln Pro Leu Met Asp 
                245                 250                 255     


Asn Leu Glu Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro Ile Lys 
            260                 265                 270         


Tyr Ser Gln Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp Arg Val 
        275                 280                 285             


Pro Glu Glu Glu Lys Asp Thr Asn Val Gln Val Leu Met Val Leu Gly 
    290                 295                 300                 


Ala Gly Arg Gly Pro Leu Val Asn Ala Ser Leu Arg Ala Ala Lys Gln 
305                 310                 315                 320 


Ala Asp Arg Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro Asn Ala 
                325                 330                 335     


Val Val Thr Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser Gln Val 
            340                 345                 350         


Thr Val Val Ser Ser Asp Met Arg Glu Trp Val Ala Pro Glu Lys Ala 
        355                 360                 365             


Asp Ile Ile Val Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn Glu Leu 
    370                 375                 380                 


Ser Pro Glu Cys Leu Asp Gly Ala Gln His Phe Leu Lys Asp Asp Gly 
385                 390                 395                 400 


Val Ser Ile Pro Gly Glu Tyr Thr Ser Phe Leu Ala Pro Ile Ser Ser 
                405                 410                 415     


Ser Lys Leu Tyr Asn Glu Val Arg Ala Cys Arg Glu Lys Asp Arg Asp 
            420                 425                 430         


Pro Glu Ala Gln Phe Glu Met Pro Tyr Val Val Arg Leu His Asn Phe 
        435                 440                 445             


His Gln Leu Ser Ala Pro Gln Pro Cys Phe Thr Phe Ser His Pro Asn 
    450                 455                 460                 


Arg Asp Pro Met Ile Asp Asn Asn Arg Tyr Cys Thr Leu Glu Phe Pro 
465                 470                 475                 480 


Val Glu Val Asn Thr Val Leu His Gly Phe Ala Gly Tyr Phe Glu Thr 
                485                 490                 495     


Val Leu Tyr Gln Asp Ile Thr Leu Ser Ile Arg Pro Glu Thr His Ser 
            500                 505                 510         


Pro Gly Met Phe Ser Trp Phe Pro Ile Leu Phe Pro Ile Lys Gln Pro 
        515                 520                 525             


Ile Thr Val Arg Glu Gly Gln Thr Ile Cys Val Arg Phe Trp Arg Cys 
    530                 535                 540                 


Ser Asn Ser Lys Lys Val Trp Tyr Glu Trp Ala Val Thr Ala Pro Val 
545                 550                 555                 560 


Cys Ser Ala Ile His Asn Pro Thr Gly Arg Ser Tyr Thr Ile Gly Leu 
                565                 570                 575     


<210> 4706
<211> 188
<212> PRT
<213> Homo sapiens

<400> 4706
Met Glu Asp Glu Arg Ser Phe Ser Asp Ile Cys Gly Gly Arg Leu Ala 
1               5                   10                  15      


Leu Gln Arg Arg Tyr Tyr Ser Pro Ser Cys Arg Glu Phe Cys Leu Ser 
            20                  25                  30          


Cys Pro Arg Leu Ser Leu Arg Ser Leu Thr Ala Val Thr Cys Thr Val 
        35                  40                  45              


Trp Leu Ala Ala Tyr Gly Leu Phe Thr Leu Cys Glu Asn Ser Met Ile 
    50                  55                  60                  


Leu Ser Ala Ala Ile Phe Ile Thr Leu Leu Gly Leu Leu Gly Tyr Leu 
65                  70                  75                  80  


His Phe Val Lys Ile Asp Gln Glu Thr Leu Leu Ile Ile Asp Ser Leu 
                85                  90                  95      


Gly Ile Gln Met Thr Ser Ser Tyr Ala Ser Gly Lys Glu Ser Thr Thr 
            100                 105                 110         


Phe Ile Glu Met Gly Lys Val Lys Asp Ile Val Ile Asn Glu Ala Ile 
        115                 120                 125             


Tyr Met Gln Lys Val Ile Tyr Tyr Leu Cys Ile Leu Leu Lys Asp Pro 
    130                 135                 140                 


Val Glu Pro His Gly Ile Ser Gln Val Val Pro Val Phe Gln Ser Ala 
145                 150                 155                 160 


Lys Pro Arg Leu Asp Cys Leu Ile Glu Val Tyr Arg Ser Cys Gln Glu 
                165                 170                 175     


Ile Leu Ala His Gln Lys Ala Thr Ser Thr Ser Pro 
            180                 185             


<210> 4707
<211> 338
<212> PRT
<213> Homo sapiens

<400> 4707
Met Ala Lys Trp Gly Glu Gly Asp Pro Arg Trp Ile Val Glu Glu Arg 
1               5                   10                  15      


Ala Asp Ala Thr Asn Val Asn Asn Trp His Trp Thr Glu Arg Asp Ala 
            20                  25                  30          


Ser Asn Trp Ser Thr Asp Lys Leu Lys Thr Leu Phe Leu Ala Val Gln 
        35                  40                  45              


Val Gln Asn Glu Glu Gly Lys Cys Glu Val Thr Glu Val Ser Lys Leu 
    50                  55                  60                  


Asp Gly Glu Ala Ser Ile Asn Asn Arg Lys Gly Lys Leu Ile Phe Phe 
65                  70                  75                  80  


Tyr Glu Trp Ser Val Lys Leu Asn Trp Thr Gly Thr Ser Lys Ser Gly 
                85                  90                  95      


Val Gln Tyr Lys Gly His Val Glu Ile Pro Asn Leu Ser Asp Glu Asn 
            100                 105                 110         


Ser Val Asp Glu Val Glu Ile Ser Val Ser Leu Ala Lys Asp Glu Pro 
        115                 120                 125             


Asp Thr Asn Leu Val Ala Leu Met Lys Glu Glu Gly Val Lys Leu Leu 
    130                 135                 140                 


Arg Glu Ala Met Gly Ile Tyr Ile Ser Thr Leu Lys Thr Glu Phe Thr 
145                 150                 155                 160 


Gln Gly Met Ile Leu Pro Thr Met Asn Gly Glu Ser Val Asp Pro Val 
                165                 170                 175     


Gly Gln Pro Ala Leu Lys Thr Glu Glu Arg Lys Ala Lys Pro Ala Pro 
            180                 185                 190         


Ser Lys Thr Gln Ala Arg Pro Val Gly Val Lys Ile Pro Thr Cys Lys 
        195                 200                 205             


Ile Thr Leu Lys Glu Thr Phe Leu Thr Ser Pro Glu Glu Leu Tyr Arg 
    210                 215                 220                 


Val Phe Thr Thr Gln Glu Leu Val Gln Ala Phe Thr His Ala Pro Ala 
225                 230                 235                 240 


Thr Leu Glu Ala Asp Arg Gly Gly Lys Phe His Met Val Asp Gly Asn 
                245                 250                 255     


Val Ser Gly Glu Phe Thr Asp Leu Val Pro Glu Lys His Ile Val Met 
            260                 265                 270         


Lys Trp Arg Phe Lys Ser Trp Pro Glu Gly His Phe Ala Thr Ile Thr 
        275                 280                 285             


Leu Thr Phe Ile Asp Lys Asn Gly Glu Thr Glu Leu Cys Met Glu Gly 
    290                 295                 300                 


Arg Gly Ile Pro Ala Pro Glu Glu Glu Arg Thr Arg Gln Gly Trp Gln 
305                 310                 315                 320 


Arg Tyr Tyr Phe Glu Gly Ile Lys Gln Thr Phe Gly Tyr Gly Ala Arg 
                325                 330                 335     


Leu Phe 
        


<210> 4708
<211> 985
<212> PRT
<213> Homo sapiens

<400> 4708
Met Ile Arg His Ala Gly Ala Pro Ala Arg Gly Asp Pro Thr Gly Pro 
1               5                   10                  15      


Val Pro Val Val Gly Lys Gly Glu Glu Glu Glu Glu Glu Asp Gly Met 
            20                  25                  30          


Arg Leu Cys Leu Pro Ala Asn Pro Lys Asn Cys Leu Pro His Arg Arg 
        35                  40                  45              


Gly Ile Ser Ile Leu Glu Lys Leu Ile Lys Thr Cys Pro Val Trp Leu 
    50                  55                  60                  


Gln Leu Ser Leu Gly Gln Ala Glu Val Ala Arg Ile Leu His Arg Val 
65                  70                  75                  80  


Val Ala Gly Met Phe Leu Val Arg Arg Asp Ser Ser Ser Lys Gln Leu 
                85                  90                  95      


Val Leu Cys Val His Phe Pro Ser Leu Asn Glu Ser Ser Ala Glu Val 
            100                 105                 110         


Leu Glu Tyr Thr Ile Lys Glu Glu Lys Ser Ile Leu Tyr Leu Glu Gly 
        115                 120                 125             


Ser Ala Leu Val Phe Glu Asp Ile Phe Arg Leu Ile Ala Phe Tyr Cys 
    130                 135                 140                 


Val Ser Arg Asp Leu Leu Pro Phe Thr Leu Arg Leu Pro Gln Ala Ile 
145                 150                 155                 160 


Leu Glu Ala Ser Ser Phe Thr Asp Leu Glu Thr Ile Ala Asn Leu Gly 
                165                 170                 175     


Leu Gly Phe Trp Asp Ser Ser Leu Asn Pro Pro Gln Glu Arg Gly Lys 
            180                 185                 190         


Pro Ala Glu Pro Pro Arg Asp Arg Ala Pro Gly Phe Pro Leu Val Ser 
        195                 200                 205             


Ser Leu Arg Pro Thr Ala His Asp Ala Asn Cys Ala Cys Glu Ile Glu 
    210                 215                 220                 


Leu Ser Val Gly Asn Asp Arg Leu Trp Phe Val Asn Pro Ile Phe Ile 
225                 230                 235                 240 


Glu Asp Cys Ser Ser Ala Leu Pro Thr Asp Gln Pro Pro Leu Gly Asn 
                245                 250                 255     


Cys Pro Ala Arg Pro Leu Pro Pro Thr Ser Asp Ala Thr Ser Pro Thr 
            260                 265                 270         


Ser Arg Trp Ala Pro Arg Arg Pro Pro Pro Pro Pro Pro Val Leu Pro 
        275                 280                 285             


Leu Gln Pro Cys Ser Pro Ala Gln Pro Pro Val Leu Pro Ala Leu Ala 
    290                 295                 300                 


Pro Ala Pro Ala Cys Pro Leu Pro Thr Ser Pro Pro Val Pro Ala Pro 
305                 310                 315                 320 


His Val Thr Pro His Ala Pro Gly Pro Pro Asp His Pro Asn Gln Pro 
                325                 330                 335     


Pro Met Met Thr Cys Glu Arg Leu Pro Cys Pro Thr Ala Gly Leu Gly 
            340                 345                 350         


Pro Leu Arg Glu Glu Ala Met Lys Pro Gly Ala Ala Ser Ser Pro Leu 
        355                 360                 365             


Gln Gln Val Pro Ala Pro Pro Leu Pro Ala Lys Lys Asn Leu Pro Thr 
    370                 375                 380                 


Ala Pro Pro Arg Arg Arg Val Ser Glu Arg Val Ser Leu Glu Asp Gln 
385                 390                 395                 400 


Ser Pro Gly Met Ala Ala Glu Gly Asp Gln Leu Ser Leu Pro Pro Gln 
                405                 410                 415     


Gly Thr Ser Asp Gly Pro Glu Asp Thr Pro Arg Glu Ser Thr Glu Gln 
            420                 425                 430         


Gly Gln Asp Thr Glu Val Lys Ala Ser Asp Pro His Ser Met Pro Glu 
        435                 440                 445             


Leu Pro Arg Thr Ala Lys Gln Pro Pro Val Pro Pro Pro Arg Lys Lys 
    450                 455                 460                 


Arg Ile Ser Arg Gln Leu Ala Ser Thr Leu Pro Ala Pro Leu Glu Asn 
465                 470                 475                 480 


Ala Glu Leu Cys Thr Gln Ala Met Ala Leu Glu Thr Pro Thr Pro Gly 
                485                 490                 495     


Pro Pro Arg Glu Gly Gln Ser Pro Ala Ser Gln Ala Gly Thr Gln His 
            500                 505                 510         


Pro Pro Ala Gln Ala Thr Ala His Ser Gln Ser Ser Pro Glu Phe Lys 
        515                 520                 525             


Gly Ser Leu Ala Ser Leu Ser Asp Ser Leu Gly Val Ser Val Met Ala 
    530                 535                 540                 


Thr Asp Gln Asp Ser Tyr Ser Thr Ser Ser Thr Glu Glu Glu Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Ser Pro Ser Val Lys Lys Lys Pro Ser Met Ile Leu Gly 
                565                 570                 575     


Lys Ala Arg His Arg Leu Ser Phe Ala Ser Phe Ser Ser Met Phe His 
            580                 585                 590         


Ala Phe Leu Ser Asn Asn Arg Lys Leu Tyr Lys Lys Val Val Glu Leu 
        595                 600                 605             


Ala Gln Asp Lys Gly Ser Tyr Phe Gly Ser Leu Val Gln Asp Tyr Lys 
    610                 615                 620                 


Val Tyr Ser Leu Glu Met Met Ala Arg Gln Thr Ser Ser Thr Glu Met 
625                 630                 635                 640 


Leu Gln Glu Ile Arg Thr Met Met Thr Gln Leu Lys Ser Tyr Leu Leu 
                645                 650                 655     


Gln Ser Thr Glu Leu Lys Ala Leu Val Asp Pro Ala Leu His Ser Glu 
            660                 665                 670         


Glu Glu Leu Glu Ala Ile Val Glu Ser Ala Leu Tyr Lys Cys Val Leu 
        675                 680                 685             


Lys Pro Leu Lys Glu Ala Ile Asn Ser Cys Leu His Gln Ile His Ser 
    690                 695                 700                 


Lys Asp Gly Ser Leu Gln Gln Leu Lys Glu Asn Gln Leu Val Ile Leu 
705                 710                 715                 720 


Ala Thr Thr Thr Thr Asp Leu Gly Val Thr Thr Ser Val Pro Glu Val 
                725                 730                 735     


Pro Met Met Glu Lys Ile Leu Gln Lys Phe Thr Ser Met His Lys Ala 
            740                 745                 750         


Tyr Ser Pro Glu Lys Lys Ile Ser Ile Leu Leu Lys Thr Cys Lys Leu 
        755                 760                 765             


Ile Tyr Asp Ser Met Ala Leu Gly Asn Pro Gly Lys Pro Tyr Gly Ala 
    770                 775                 780                 


Asp Asp Phe Leu Pro Val Leu Met Tyr Val Leu Ala Arg Ser Asn Leu 
785                 790                 795                 800 


Thr Glu Met Leu Leu Asn Val Glu Tyr Met Met Glu Leu Met Asp Pro 
                805                 810                 815     


Ala Leu Gln Leu Gly Glu Gly Ser Tyr Tyr Leu Thr Thr Thr Tyr Gly 
            820                 825                 830         


Ala Leu Glu His Ile Lys Ser Tyr Asp Lys Ile Thr Val Thr Arg Gln 
        835                 840                 845             


Leu Ser Val Glu Val Gln Asp Ser Ile His Arg Trp Glu Arg Arg Arg 
    850                 855                 860                 


Thr Leu Asn Lys Ala Arg Ala Ser Arg Ser Ser Val Gln Asp Phe Ile 
865                 870                 875                 880 


Cys Val Ser Tyr Leu Glu Pro Glu Gln Gln Ala Arg Thr Leu Ala Ser 
                885                 890                 895     


Arg Ala Asp Thr Gln Ala Gln Ala Leu Cys Ala Gln Cys Ala Glu Lys 
            900                 905                 910         


Phe Ala Val Glu Arg Pro Gln Ala His Arg Leu Phe Val Leu Val Asp 
        915                 920                 925             


Gly Arg Cys Phe Gln Leu Ala Asp Asp Ala Leu Pro His Cys Ile Lys 
    930                 935                 940                 


Gly Tyr Leu Leu Arg Ser Glu Pro Lys Arg Asp Phe His Phe Val Tyr 
945                 950                 955                 960 


Arg Pro Leu Asp Gly Gly Gly Gly Gly Gly Gly Gly Ser Pro Pro Cys 
                965                 970                 975     


Leu Val Val Arg Glu Pro Asn Phe Leu 
            980                 985 


<210> 4709
<211> 435
<212> PRT
<213> Homo sapiens

<400> 4709
Met Ala Glu Ser Ser Ser Glu Ser Asp His Phe Arg Cys Arg Asp Arg 
1               5                   10                  15      


Leu Ser Pro Trp Ala Ala Arg Ser Thr His Arg Gly Thr Arg Ser Leu 
            20                  25                  30          


Pro Thr Val Glu Val Thr Glu Lys Val Asn Thr Ile Thr Ser Thr Leu 
        35                  40                  45              


Gln Asp Thr Ser Arg Asn Leu Arg Gln Val Asp Gln Met Leu Gly Arg 
    50                  55                  60                  


Tyr Arg Glu Tyr Ser Asn Gly Gln Ala Gly Ala Ile Glu His Leu Lys 
65                  70                  75                  80  


Glu Ser Leu Glu Gln Ser Ile Asp Gln Leu Arg Ser Gln Arg Leu Leu 
                85                  90                  95      


Arg Asn Ser Gly Gly Arg Ser Ile Ser Val Thr Ser Leu Ser Ala Ser 
            100                 105                 110         


Asp Leu Asp Gly Gly Thr Gly Ser Glu Leu His His Phe Pro Pro Thr 
        115                 120                 125             


Ser Pro Leu Lys Asp Tyr Gly Asp Pro Gln Gly Ile Lys Arg Met Arg 
    130                 135                 140                 


Ser Arg Thr Gly Val Arg Phe Val Gln Glu Thr Asp Asp Met Thr Gln 
145                 150                 155                 160 


Leu His Gly Phe His Gln Ser Leu Arg Asp Leu Ser Ser Glu Gln Ile 
                165                 170                 175     


Arg Leu Gly Asp Asp Phe Asn Arg Glu Leu Ser Arg Arg Ser Arg Ser 
            180                 185                 190         


Asp Ala Glu Thr Lys Arg Ala Leu Glu Glu Leu Thr Glu Lys Leu Asn 
        195                 200                 205             


Glu Ala Gln Lys Gln Glu Val Val Ser Asp Arg Val Glu Arg Arg Leu 
    210                 215                 220                 


Gln Glu Leu Glu Arg Glu Met Arg Thr Glu Arg Glu Leu Val Glu Arg 
225                 230                 235                 240 


Arg Gln Asp Gln Leu Gly Leu Met Ser Leu Gln Leu Gln Glu Ala Leu 
                245                 250                 255     


Lys Lys Gln Glu Ala Lys Ala Asp Glu His Glu Gly Ala Ile Lys Asn 
            260                 265                 270         


Lys Leu Arg Gln Thr Glu Thr Glu Lys Asn Gln Leu Glu Gln Glu Leu 
        275                 280                 285             


Glu Leu Ser Arg Arg Leu Leu Asn Gln Ser Glu Gly Ser Arg Glu Thr 
    290                 295                 300                 


Leu Leu His Gln Val Glu Glu Leu Arg Thr Gln Leu Thr Lys Ala Glu 
305                 310                 315                 320 


Gly Asp Arg Lys Gly Leu Gln His Gln Val Ser Gln Ile Ser Lys Gln 
                325                 330                 335     


Gln Ser Asn Tyr Gln Asp Glu Gln Gly Glu Asp Trp Arg Phe Arg Arg 
            340                 345                 350         


Gly Val Glu Arg Glu Lys Gln Asp Leu Glu Lys Gln Met Ser Asp Leu 
        355                 360                 365             


Arg Val Gln Leu Asn Phe Ser Ala Met Ala Ser Glu Leu Glu Glu Val 
    370                 375                 380                 


Lys Arg Cys Met Glu Arg Lys Asp Lys Glu Lys Ala His Leu Ala Ser 
385                 390                 395                 400 


Gln Val Glu His Ile Asn Arg Lys Cys Leu Leu Asn Leu Val Gln Asp 
                405                 410                 415     


Leu Asp Cys Lys Asp Asn Glu Ile Leu Thr Tyr Ser Leu Gln Ser Pro 
            420                 425                 430         


Leu His Val 
        435 


<210> 4710
<211> 451
<212> PRT
<213> Homo sapiens

<400> 4710
Met Val Ser Arg Asp Gln Ala His Leu Gly Pro Lys Tyr Val Gly Leu 
1               5                   10                  15      


Trp Asp Phe Lys Ser Arg Thr Asp Glu Glu Leu Ser Phe Arg Ala Gly 
            20                  25                  30          


Asp Val Phe His Val Ala Arg Lys Glu Glu Gln Trp Trp Trp Ala Thr 
        35                  40                  45              


Leu Leu Asp Glu Ala Gly Gly Ala Val Ala Gln Gly Tyr Val Pro His 
    50                  55                  60                  


Asn Tyr Leu Ala Glu Arg Glu Thr Val Glu Ser Glu Pro Trp Phe Phe 
65                  70                  75                  80  


Gly Cys Ile Ser Arg Ser Glu Ala Val Arg Arg Leu Gln Ala Glu Gly 
                85                  90                  95      


Asn Ala Thr Gly Ala Phe Leu Ile Arg Val Ser Glu Lys Pro Ser Ala 
            100                 105                 110         


Asp Tyr Val Leu Ser Val Arg Asp Thr Gln Ala Val Arg His Tyr Lys 
        115                 120                 125             


Ile Trp Arg Arg Ala Gly Gly Arg Leu His Leu Asn Glu Ala Val Ser 
    130                 135                 140                 


Phe Leu Ser Leu Pro Glu Leu Val Asn Tyr His Arg Ala Gln Ser Leu 
145                 150                 155                 160 


Ser His Gly Leu Arg Leu Ala Ala Pro Cys Arg Lys His Glu Pro Glu 
                165                 170                 175     


Pro Leu Pro His Trp Asp Asp Trp Glu Arg Pro Arg Glu Glu Phe Thr 
            180                 185                 190         


Leu Cys Arg Lys Leu Gly Ser Gly Tyr Phe Gly Glu Val Phe Glu Gly 
        195                 200                 205             


Leu Trp Lys Asp Arg Val Gln Val Ala Ile Lys Val Ile Ser Arg Asp 
    210                 215                 220                 


Asn Leu Leu His Gln Gln Met Leu Gln Ser Glu Ile Gln Ala Met Lys 
225                 230                 235                 240 


Lys Leu Arg His Lys His Ile Leu Ala Leu Tyr Ala Val Val Ser Val 
                245                 250                 255     


Gly Asp Pro Val Tyr Ile Ile Thr Glu Leu Met Ala Lys Gly Ser Leu 
            260                 265                 270         


Leu Glu Leu Leu Arg Asp Ser Asp Glu Lys Val Leu Pro Val Ser Glu 
        275                 280                 285             


Leu Leu Asp Ile Ala Trp Gln Val Ala Glu Gly Met Cys Tyr Leu Glu 
    290                 295                 300                 


Ser Gln Asn Tyr Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
305                 310                 315                 320 


Gly Glu Asn Thr Leu Cys Lys Val Gly Asp Phe Gly Leu Ala Arg Leu 
                325                 330                 335     


Ile Lys Glu Asp Val Tyr Leu Ser His Asp His Asn Ile Pro Tyr Lys 
            340                 345                 350         


Trp Thr Ala Pro Glu Ala Leu Ser Arg Gly His Tyr Ser Thr Lys Ser 
        355                 360                 365             


Asp Val Trp Ser Phe Gly Ile Leu Leu His Glu Met Phe Ser Arg Gly 
    370                 375                 380                 


Gln Val Pro Tyr Pro Gly Met Ser Asn His Glu Ala Phe Leu Arg Val 
385                 390                 395                 400 


Asp Ala Gly Tyr Arg Met Pro Cys Pro Leu Glu Cys Pro Pro Ser Val 
                405                 410                 415     


His Lys Leu Met Leu Thr Cys Trp Cys Arg Asp Pro Glu Gln Arg Pro 
            420                 425                 430         


Cys Phe Lys Ala Leu Arg Glu Arg Leu Ser Ser Phe Thr Ser Tyr Glu 
        435                 440                 445             


Asn Pro Thr 
    450     


<210> 4711
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 4711
Xaa Ser Glu Val Pro Leu Pro Pro Gly Ala Leu Ala Thr Leu Ser Ser 
1               5                   10                  15      


Ser Cys Ser Leu Gly Val Ala Leu His Arg Ser Ser Pro Ala Ser Arg 
            20                  25                  30          


Gly Pro Gly Glu Ser Ser Leu Pro Ala Phe Ser Gly Val Ala Leu Leu 
        35                  40                  45              


Pro Pro Ala Cys Lys Ala Gly Leu Pro Tyr Asn Leu Ser Arg Gln Glu 
    50                  55                  60                  


Gly His Leu Thr Cys Leu Ser Ile Pro Asp Ile Lys Thr Ala Phe Ser 
65                  70                  75                  80  


Asp Cys Thr Ser Lys Ile Gly Arg Arg Asp Cys Leu Thr Gln Ala Cys 
                85                  90                  95      


Ser Ala Leu Thr Gly Lys Gly Val Arg Glu Gly Ile Glu Trp Met Val 
            100                 105                 110         


Lys Cys Val Val Arg Asn Val His Arg Pro Pro Arg Gln Arg Asp Ile 
        115                 120                 125             


Thr 
    


<210> 4712
<211> 615
<212> PRT
<213> Homo sapiens

<400> 4712
Met Ala Arg Ala Cys Leu Ile Gln Arg Leu Pro Ile Lys Arg Asp Cys 
1               5                   10                  15      


Thr Pro Val Phe Val Arg Gly Leu Ser Ser Pro Ser Ala Ala Met Ala 
            20                  25                  30          


Leu Leu Ser Glu Gly Leu Asp Glu Val Pro Ala Ala Cys Leu Ser Pro 
        35                  40                  45              


Cys Gly Pro Pro Asn Pro Thr Glu Leu Phe Ser Glu Ser Arg Arg Leu 
    50                  55                  60                  


Ala Leu Glu Glu Leu Val Ala Gly Gly Pro Glu Ala Phe Ala Ala Phe 
65                  70                  75                  80  


Leu Arg Arg Glu Arg Leu Ala Arg Phe Leu Asn Pro Asp Glu Val His 
                85                  90                  95      


Ala Ile Leu Arg Ala Ala Glu Arg Pro Gly Glu Glu Gly Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Glu Asp Ser Phe Gly Ser Ser His Asp Cys Ser Ser 
        115                 120                 125             


Gly Thr Tyr Phe Pro Glu Gln Ser Asp Leu Glu Pro Pro Leu Leu Glu 
    130                 135                 140                 


Leu Gly Trp Pro Ala Phe Tyr Gln Gly Ala Tyr Arg Gly Ala Thr Arg 
145                 150                 155                 160 


Val Glu Thr His Phe Gln Pro Arg Gly Ala Gly Glu Gly Gly Pro Tyr 
                165                 170                 175     


Gly Cys Lys Asp Ala Leu Arg Gln Gln Leu Arg Ser Ala Arg Glu Val 
            180                 185                 190         


Ile Ala Val Val Met Asp Val Phe Thr Asp Ile Asp Ile Phe Arg Asp 
        195                 200                 205             


Leu Gln Glu Ile Cys Arg Lys Gln Gly Val Ala Val Tyr Ile Leu Leu 
    210                 215                 220                 


Asp Gln Ala Leu Leu Ser Gln Phe Leu Asp Met Cys Met Asp Leu Lys 
225                 230                 235                 240 


Val His Pro Glu Gln Glu Lys Leu Met Thr Val Arg Thr Ile Thr Gly 
                245                 250                 255     


Asn Ile Tyr Tyr Ala Arg Ser Gly Thr Lys Ile Ile Gly Lys Val His 
            260                 265                 270         


Glu Lys Phe Thr Leu Ile Asp Gly Ile Arg Val Ala Thr Gly Ser Tyr 
        275                 280                 285             


Ser Phe Thr Trp Thr Asp Gly Lys Leu Asn Ser Ser Asn Leu Val Ile 
    290                 295                 300                 


Leu Ser Gly Gln Val Val Glu His Phe Asp Leu Glu Phe Arg Ile Leu 
305                 310                 315                 320 


Tyr Ala Gln Ser Lys Pro Ile Ser Pro Lys Leu Leu Ser His Phe Gln 
                325                 330                 335     


Ser Ser Asn Lys Phe Asp His Leu Thr Asn Arg Lys Pro Gln Ser Lys 
            340                 345                 350         


Glu Leu Thr Leu Gly Asn Leu Leu Arg Met Arg Leu Ala Arg Leu Ser 
        355                 360                 365             


Ser Thr Pro Arg Lys Ala Asp Leu Asp Pro Glu Met Pro Ala Glu Gly 
    370                 375                 380                 


Lys Ala Glu Arg Lys Pro His Asp Cys Glu Ser Ser Thr Val Ser Glu 
385                 390                 395                 400 


Glu Asp Tyr Phe Ser Ser His Arg Asp Glu Leu Gln Ser Arg Lys Ala 
                405                 410                 415     


Ile Asp Ala Ala Thr Gln Thr Glu Pro Gly Glu Glu Met Pro Gly Leu 
            420                 425                 430         


Ser Val Ser Glu Val Gly Thr Gln Thr Ser Ile Thr Thr Ala Cys Ala 
        435                 440                 445             


Gly Thr Gln Thr Ala Val Ile Thr Arg Ile Ala Ser Ser Gln Thr Thr 
    450                 455                 460                 


Ile Trp Ser Arg Ser Thr Thr Thr Gln Thr Asp Met Asp Glu Asn Ile 
465                 470                 475                 480 


Leu Phe Pro Arg Gly Thr Gln Ser Thr Glu Gly Ser Pro Val Ser Lys 
                485                 490                 495     


Met Ser Val Ser Arg Ser Ser Ser Leu Lys Ser Ser Ser Ser Val Ser 
            500                 505                 510         


Ser Gln Gly Ser Val Ala Ser Ser Thr Gly Ser Pro Ala Ser Ile Arg 
        515                 520                 525             


Thr Thr Asp Phe His Asn Pro Gly Tyr Pro Lys Tyr Leu Gly Thr Pro 
    530                 535                 540                 


His Leu Glu Leu Tyr Leu Ser Asp Ser Leu Arg Asn Leu Asn Lys Glu 
545                 550                 555                 560 


Arg Gln Phe His Phe Ala Gly Ile Arg Ser Arg Leu Asn His Met Leu 
                565                 570                 575     


Ala Met Leu Ser Arg Arg Thr Leu Phe Thr Glu Asn His Leu Gly Leu 
            580                 585                 590         


His Ser Gly Asn Phe Ser Arg Val Asn Leu Leu Ala Val Arg Asp Val 
        595                 600                 605             


Ala Leu Tyr Pro Ser Tyr Gln 
    610                 615 


<210> 4713
<211> 289
<212> PRT
<213> Homo sapiens

<400> 4713
Met Val Gly Val Lys Pro Val Gly Ser Asp Pro Asp Phe Gln Pro Glu 
1               5                   10                  15      


Leu Ser Gly Ala Gly Ser Arg Leu Ala Val Val Lys Phe Thr Met Arg 
            20                  25                  30          


Gly Cys Gly Pro Cys Leu Arg Ile Ala Pro Ala Phe Ser Ser Met Ser 
        35                  40                  45              


Asn Lys Tyr Pro Gln Ala Val Phe Leu Glu Val Asp Val His Gln Cys 
    50                  55                  60                  


Gln Gly Thr Ala Ala Thr Asn Asn Ile Ser Ala Thr Pro Thr Phe Leu 
65                  70                  75                  80  


Phe Phe Arg Asn Lys Val Arg Ile Asp Gln Tyr Gln Gly Ala Asp Ala 
                85                  90                  95      


Val Gly Leu Glu Glu Lys Ile Lys Gln His Leu Glu Asn Asp Pro Gly 
            100                 105                 110         


Ser Asn Glu Asp Thr Asp Ile Pro Lys Gly Tyr Met Asp Leu Met Pro 
        115                 120                 125             


Phe Ile Asn Lys Ala Gly Cys Glu Cys Leu Asn Glu Ser Asp Glu His 
    130                 135                 140                 


Gly Phe Asp Asn Cys Leu Arg Lys Asp Thr Thr Phe Leu Glu Ser Asp 
145                 150                 155                 160 


Cys Asp Glu Gln Leu Leu Ile Thr Val Ala Phe Asn Gln Pro Val Lys 
                165                 170                 175     


Leu Tyr Ser Met Lys Phe Gln Gly Pro Asp Asn Gly Gln Gly Pro Lys 
            180                 185                 190         


Tyr Val Lys Ile Phe Ile Asn Leu Pro Arg Ser Met Asp Phe Glu Glu 
        195                 200                 205             


Ala Glu Arg Ser Glu Pro Thr Gln Ala Leu Glu Leu Thr Glu Asp Asp 
    210                 215                 220                 


Ile Lys Glu Asp Gly Ile Val Pro Leu Arg Tyr Val Lys Phe Gln Asn 
225                 230                 235                 240 


Val Asn Ser Val Thr Ile Phe Val Gln Ser Asn Gln Gly Glu Glu Glu 
                245                 250                 255     


Thr Thr Arg Ile Ser Tyr Phe Thr Phe Ile Gly Thr Pro Val Gln Ala 
            260                 265                 270         


Thr Asn Met Asn Asp Phe Lys Arg Val Val Gly Lys Lys Gly Glu Ser 
        275                 280                 285             


His 
    


<210> 4714
<211> 171
<212> PRT
<213> Homo sapiens

<400> 4714
Met Ser Ser Lys Arg Thr Lys Thr Lys Thr Lys Lys Arg Pro Gln Arg 
1               5                   10                  15      


Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 
            20                  25                  30          


Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 
        35                  40                  45              


Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro 
    50                  55                  60                  


Thr Asp Glu Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro Ile 
65                  70                  75                  80  


Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 
                85                  90                  95      


Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 
            100                 105                 110         


Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr 
        115                 120                 125             


Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu 
    130                 135                 140                 


Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg 
145                 150                 155                 160 


Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                165                 170     


<210> 4715
<211> 226
<212> PRT
<213> Homo sapiens

<400> 4715
Met Glu Gly Cys Val Ser Asn Leu Met Val Cys Asn Leu Ala Tyr Ser 
1               5                   10                  15      


Gly Lys Leu Glu Glu Leu Lys Glu Ser Ile Leu Ala Asp Lys Ser Leu 
            20                  25                  30          


Ala Thr Arg Thr Asp Gln Asp Ser Arg Thr Ala Leu His Trp Ala Cys 
        35                  40                  45              


Ser Ala Gly His Thr Glu Ile Val Glu Phe Leu Leu Gln Leu Gly Val 
    50                  55                  60                  


Pro Val Asn Asp Lys Asp Asp Ala Gly Trp Ser Pro Leu His Ile Ala 
65                  70                  75                  80  


Ala Ser Ala Gly Arg Asp Glu Ile Val Lys Ala Leu Leu Gly Lys Gly 
                85                  90                  95      


Ala Gln Val Asn Ala Val Asn Gln Asn Gly Cys Thr Pro Leu His Tyr 
            100                 105                 110         


Ala Ala Ser Lys Asn Arg His Glu Ile Ala Val Met Leu Leu Glu Gly 
        115                 120                 125             


Gly Ala Asn Pro Asp Ala Lys Asp His Tyr Glu Ala Thr Ala Met His 
    130                 135                 140                 


Arg Ala Ala Ala Lys Gly Asn Leu Lys Met Ile His Ile Leu Leu Tyr 
145                 150                 155                 160 


Tyr Lys Ala Ser Thr Asn Ile Gln Asp Thr Glu Gly Asn Thr Pro Leu 
                165                 170                 175     


His Leu Ala Cys Asp Glu Glu Arg Val Glu Glu Ala Lys Leu Leu Val 
            180                 185                 190         


Ser Gln Gly Ala Ser Ile Tyr Ile Glu Asn Lys Glu Glu Lys Thr Pro 
        195                 200                 205             


Leu Gln Val Ala Lys Gly Gly Leu Gly Leu Ile Leu Lys Arg Met Val 
    210                 215                 220                 


Glu Gly 
225     


<210> 4716
<211> 742
<212> PRT
<213> Homo sapiens

<400> 4716
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr 
1               5                   10                  15      


Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val 
            20                  25                  30          


Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His Gly Gln Asn 
        35                  40                  45              


Asn Pro Val Gly Asp Tyr Glu His Ala Asp Asp Gln Ala Glu Glu Asp 
    50                  55                  60                  


Ala Leu Gln Met Ala Val Gly Tyr Phe Glu Lys Gly Pro Ile Lys Ala 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Thr Leu Glu Lys His Leu Lys Thr Val Glu 
                85                  90                  95      


Asn Val Ala Trp Lys Asn Gly Leu Ala Ser Glu Glu Ile Asp Ile Leu 
            100                 105                 110         


Leu Asn Ile Ala Leu Ser Gly Lys Phe Gly Asn Ala Val Asn Thr Arg 
        115                 120                 125             


Ile Leu Lys Cys Met Ile Pro Ala Thr Val Ile Ser Glu Asp Ser Val 
    130                 135                 140                 


Val Lys Ala Val Ser Trp Leu Cys Val Gly Lys Cys Ser Gly Ser Thr 
145                 150                 155                 160 


Lys Val Leu Phe Tyr Arg Trp Leu Val Ala Met Phe Asp Phe Ile Asp 
                165                 170                 175     


Arg Lys Glu Gln Ile Asn Leu Leu Tyr Gly Phe Phe Phe Ala Ser Leu 
            180                 185                 190         


Gln Asp Asp Ala Leu Cys Pro Tyr Val Cys His Leu Leu Tyr Leu Leu 
        195                 200                 205             


Thr Lys Lys Glu Asn Val Lys Pro Phe Arg Val Arg Lys Leu Leu Asp 
    210                 215                 220                 


Leu Gln Ala Lys Met Gly Met Gln Pro His Leu Gln Ala Leu Leu Ser 
225                 230                 235                 240 


Leu Tyr Lys Phe Phe Ala Pro Ala Leu Ile Ser Val Ser Leu Pro Val 
                245                 250                 255     


Arg Lys Lys Ile Tyr Phe Lys Asn Ser Glu Asn Leu Trp Lys Thr Ala 
            260                 265                 270         


Leu Leu Ala Val Lys Gln Arg Asn Arg Gly Pro Ser Pro Glu Pro Leu 
        275                 280                 285             


Lys Leu Met Leu Gly Pro Ala Asn Val Arg Pro Leu Lys Arg Lys Trp 
    290                 295                 300                 


Asn Ser Leu Ser Val Ile Pro Val Leu Asn Ser Ser Ser Tyr Thr Lys 
305                 310                 315                 320 


Glu Cys Gly Lys Lys Glu Met Ser Leu Ser Asp Cys Leu Asn Arg Ser 
                325                 330                 335     


Gly Ser Phe Pro Leu Glu Gln Leu Gln Ser Phe Pro Gln Leu Leu Gln 
            340                 345                 350         


Asn Ile His Cys Leu Glu Leu Pro Ser Gln Met Gly Ser Val Leu Asn 
        355                 360                 365             


Asn Ser Leu Leu Leu His Tyr Ile Asn Cys Val Arg Asp Glu Pro Val 
    370                 375                 380                 


Leu Leu Arg Phe Tyr Tyr Trp Leu Ser Gln Thr Leu Gln Glu Glu Cys 
385                 390                 395                 400 


Ile Trp Tyr Lys Val Asn Asn Tyr Glu His Gly Lys Glu Phe Thr Asn 
                405                 410                 415     


Phe Leu Asp Thr Ile Ile Arg Ala Glu Cys Phe Leu Gln Glu Gly Phe 
            420                 425                 430         


Tyr Ser Cys Glu Ala Phe Leu Tyr Lys Ser Leu Pro Leu Trp Asp Gly 
        435                 440                 445             


Leu Cys Cys Arg Ser Gln Phe Leu Gln Leu Val Ser Trp Ile Pro Phe 
    450                 455                 460                 


Ser Ser Phe Ser Glu Val Lys Pro Leu Leu Phe Asp His Leu Ala Gln 
465                 470                 475                 480 


Leu Phe Phe Thr Ser Thr Ile Tyr Phe Lys Cys Ser Val Leu Gln Ser 
                485                 490                 495     


Leu Lys Glu Leu Leu Gln Asn Trp Leu Leu Trp Leu Ser Met Asp Ile 
            500                 505                 510         


His Met Lys Pro Val Thr Asn Ser Pro Leu Glu Thr Thr Leu Gly Gly 
        515                 520                 525             


Ser Met Asn Ser Val Ser Lys Leu Ile His Tyr Val Gly Trp Leu Ser 
    530                 535                 540                 


Thr Thr Ala Met Arg Leu Glu Ser Asn Asn Thr Phe Leu Leu His Phe 
545                 550                 555                 560 


Ile Leu Asp Phe Tyr Glu Lys Val Cys Asp Ile Tyr Ile Asn Tyr Asn 
                565                 570                 575     


Leu Pro Leu Val Val Leu Phe Pro Pro Gly Ile Phe Tyr Ser Ala Leu 
            580                 585                 590         


Leu Ser Leu Asp Thr Ser Ile Leu Asn Gln Leu Cys Phe Ile Met His 
        595                 600                 605             


Arg Tyr Arg Lys Asn Leu Thr Ala Ala Lys Lys Asn Glu Leu Val Gln 
    610                 615                 620                 


Lys Thr Lys Ser Glu Phe Asn Phe Ser Ser Lys Thr Tyr Gln Glu Phe 
625                 630                 635                 640 


Asn His Tyr Leu Thr Ser Met Val Gly Cys Leu Trp Thr Ser Lys Pro 
                645                 650                 655     


Phe Gly Lys Gly Ile Tyr Ile Asp Pro Glu Ile Leu Glu Lys Thr Gly 
            660                 665                 670         


Val Ala Glu Tyr Lys Asn Ser Leu Asn Val Val His His Pro Ser Phe 
        675                 680                 685             


Leu Ser Tyr Ala Val Ser Phe Leu Leu Gln Gly Lys Lys Trp Ser Trp 
    690                 695                 700                 


Tyr Leu Asp Tyr Leu Phe Ser Gln Gly Leu Gln Gly Leu Lys Leu Phe 
705                 710                 715                 720 


Ile Arg Ser Ser Val His His Ser Ser Ile Pro Arg Ala Glu Gly Ile 
                725                 730                 735     


Asn Cys Asn Asn Gln Tyr 
            740         


<210> 4717
<211> 127
<212> PRT
<213> Homo sapiens

<400> 4717
Met Gly Asp Lys Pro Ile Trp Glu Gln Ile Gly Ser Ser Phe Ile Gln 
1               5                   10                  15      


His Tyr Tyr Gln Leu Phe Asp Asn Asp Arg Thr Gln Leu Gly Ala Ile 
            20                  25                  30          


Tyr Ile Asp Ala Ser Cys Leu Thr Trp Glu Gly Gln Gln Phe Gln Gly 
        35                  40                  45              


Lys Ala Ala Ile Val Glu Lys Leu Ser Ser Leu Pro Phe Gln Lys Ile 
    50                  55                  60                  


Gln His Ser Ile Thr Ala Gln Asp His Gln Pro Thr Pro Asp Ser Cys 
65                  70                  75                  80  


Ile Ile Ser Met Val Val Gly Gln Leu Lys Ala Asp Glu Asp Pro Ile 
                85                  90                  95      


Met Gly Phe His Gln Met Phe Leu Leu Lys Asn Ile Asn Asp Ala Trp 
            100                 105                 110         


Val Cys Thr Asn Asp Met Phe Arg Leu Ala Leu His Asn Phe Gly 
        115                 120                 125         


<210> 4718
<211> 163
<212> PRT
<213> Homo sapiens

<400> 4718
Met Asp Ala Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala 
1               5                   10                  15      


Ser Asp Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp Ile Ile 
            20                  25                  30          


Met Asp Asp Glu Phe Gln Leu Leu Gln Arg Asn Phe Met Asp Lys Tyr 
        35                  40                  45              


Tyr Leu Glu Phe Glu Asp Thr Glu Glu Asn Lys Leu Ile Tyr Thr Pro 
    50                  55                  60                  


Ile Phe Asn Glu Tyr Ile Ser Leu Val Glu Lys Tyr Ile Glu Glu Gln 
65                  70                  75                  80  


Leu Leu Gln Arg Ile Pro Glu Phe Asn Met Ala Ala Phe Thr Thr Thr 
                85                  90                  95      


Leu Gln His His Lys Asp Glu Val Ala Gly Asp Ile Phe Asp Met Leu 
            100                 105                 110         


Leu Thr Phe Thr Asp Phe Leu Ala Phe Lys Glu Met Phe Leu Asp Tyr 
        115                 120                 125             


Arg Ala Glu Lys Glu Gly Arg Gly Leu Asp Leu Ser Ser Gly Leu Val 
    130                 135                 140                 


Val Thr Ser Leu Cys Lys Ser Ser Ser Leu Pro Ala Ser Gln Asn Asn 
145                 150                 155                 160 


Leu Arg His 
            


<210> 4719
<211> 225
<212> PRT
<213> Homo sapiens

<400> 4719
Met Leu Gly Leu Asp Ala Cys Glu Leu Gly Ala Gln Leu Leu Glu Leu 
1               5                   10                  15      


Leu Arg Leu Ala Leu Cys Ala Arg Val Leu Leu Ala Asp Lys Glu Gly 
            20                  25                  30          


Gly Pro Pro Ala Val Asp Glu Val Leu Asp Glu Ala Val Pro Glu Tyr 
        35                  40                  45              


Arg Ala Pro Gly Arg Lys Ser Leu Leu Glu Ile Arg Gln Leu Asp Pro 
    50                  55                  60                  


Asp Asp Arg Ser Leu Ala Lys Tyr Lys Arg Val Leu Leu Gly Pro Leu 
65                  70                  75                  80  


Pro Pro Ala Val Asp Pro Ser Leu Pro Asn Val Gln Val Thr Arg Leu 
                85                  90                  95      


Thr Leu Leu Ser Glu Gln Ala Pro Gly Pro Val Val Met Asp Leu Thr 
            100                 105                 110         


Gly Asp Leu Ala Val Leu Lys Asp Gln Val Phe Val Leu Lys Glu Gly 
        115                 120                 125             


Val Asp Tyr Arg Val Lys Ile Ser Phe Lys Val His Arg Glu Ile Val 
    130                 135                 140                 


Ser Gly Leu Lys Cys Leu His His Thr Tyr Arg Arg Gly Leu Arg Val 
145                 150                 155                 160 


Asp Lys Thr Val Tyr Met Val Gly Ser Tyr Gly Pro Ser Ala Gln Glu 
                165                 170                 175     


Tyr Glu Phe Val Thr Pro Val Glu Glu Ala Pro Arg Gly Ala Leu Val 
            180                 185                 190         


Arg Gly Pro Tyr Leu Val Val Ser Leu Phe Thr Asp Asp Asp Arg Thr 
        195                 200                 205             


His His Leu Ser Trp Glu Trp Gly Leu Cys Ile Cys Gln Asp Trp Lys 
    210                 215                 220                 


Asp 
225 


<210> 4720
<211> 235
<212> PRT
<213> Homo sapiens

<400> 4720
Met Glu Glu Glu Thr His Thr Asp Ala Lys Ile Arg Ala Glu Asn Gly 
1               5                   10                  15      


Thr Gly Ser Ser Pro Arg Gly Pro Gly Cys Ser Leu Arg His Phe Ala 
            20                  25                  30          


Cys Glu Gln Asn Leu Leu Ser Arg Pro Asp Gly Ser Ala Ser Phe Leu 
        35                  40                  45              


Gln Gly Asp Thr Ser Val Leu Ala Gly Val Tyr Gly Pro Ala Glu Val 
    50                  55                  60                  


Lys Val Ser Lys Glu Ile Phe Asn Lys Ala Thr Leu Glu Val Ile Leu 
65                  70                  75                  80  


Arg Pro Lys Ile Gly Leu Pro Gly Val Ala Glu Lys Ser Arg Glu Arg 
                85                  90                  95      


Leu Ile Arg Asn Thr Cys Glu Ala Val Val Leu Gly Thr Leu His Pro 
            100                 105                 110         


Arg Thr Ser Ile Thr Val Val Leu Gln Val Val Ser Asp Ala Gly Ser 
        115                 120                 125             


Leu Leu Ala Cys Cys Leu Asn Ala Ala Cys Met Ala Leu Val Asp Ala 
    130                 135                 140                 


Gly Val Pro Met Arg Ala Leu Phe Cys Gly Val Ala Cys Ala Leu Asp 
145                 150                 155                 160 


Ser Asp Gly Thr Leu Val Leu Asp Pro Thr Ser Lys Gln Glu Lys Glu 
                165                 170                 175     


Ala Arg Ala Val Leu Thr Phe Ala Leu Asp Ser Val Glu Arg Lys Leu 
            180                 185                 190         


Leu Met Ser Ser Thr Lys Gly Leu Tyr Ser Asp Thr Glu Leu Gln Gln 
        195                 200                 205             


Cys Leu Ala Ala Ala Gln Ala Ala Ser Gln His Val Phe Arg Phe Tyr 
    210                 215                 220                 


Arg Glu Ser Leu Gln Arg Arg Tyr Ser Lys Ser 
225                 230                 235 


<210> 4721
<211> 402
<212> PRT
<213> Homo sapiens

<400> 4721
Met Pro Trp Lys Leu Trp Arg Gly Ser Val Gly Cys Pro Gly Asp Leu 
1               5                   10                  15      


Ser Ser Asp Gly Leu Leu Phe Arg Leu Gly Pro Pro Lys Pro Pro Thr 
            20                  25                  30          


Glu Leu Glu Pro Glu Pro Glu Ile Glu Gly Leu Leu Thr Pro Val Leu 
        35                  40                  45              


Glu Ala Gly Asp Val Asp Glu Gly Pro Val Ala Arg Pro Leu Ser Pro 
    50                  55                  60                  


Thr Arg Leu Gln Pro Ala Leu Pro Pro Glu Ala Gln Ser Val Pro Glu 
65                  70                  75                  80  


Leu Glu Glu Val Ala Arg Val Leu Ala Glu Ile Pro Arg Pro Leu Lys 
                85                  90                  95      


Arg Arg Gly Ser Met Glu Gln Ala Pro Ala Val Ala Leu Pro Pro Thr 
            100                 105                 110         


His Lys Lys Gln Tyr Gln Gln Ile Ile Ser Arg Leu Phe His Arg His 
        115                 120                 125             


Gly Gly Pro Gly Pro Gly Gly Pro Glu Pro Glu Leu Ser Pro Ile Thr 
    130                 135                 140                 


Glu Gly Ser Glu Ala Arg Ala Gly Pro Pro Ala Pro Ala Pro Pro Ala 
145                 150                 155                 160 


Pro Ile Pro Pro Pro Ala Pro Ser Gln Ser Ser Pro Pro Glu Gln Pro 
                165                 170                 175     


Gln Ser Met Glu Met Arg Ser Val Leu Arg Lys Ala Gly Ser Pro Arg 
            180                 185                 190         


Lys Ala Arg Arg Ala Arg Leu Asn Pro Leu Val Leu Leu Leu Asp Ala 
        195                 200                 205             


Ala Leu Thr Gly Glu Leu Glu Val Val Gln Gln Ala Val Lys Glu Met 
    210                 215                 220                 


Asn Asp Pro Ser Gln Pro Asn Glu Glu Gly Ile Thr Ala Leu His Asn 
225                 230                 235                 240 


Ala Ile Cys Gly Ala Asn Tyr Ser Ile Val Asp Phe Leu Ile Thr Ala 
                245                 250                 255     


Gly Ala Asn Val Asn Ser Pro Asp Ser His Gly Trp Thr Pro Leu His 
            260                 265                 270         


Cys Ala Ala Ser Cys Asn Asp Thr Val Ile Cys Met Ala Leu Val Gln 
        275                 280                 285             


His Gly Ala Ala Ile Phe Ala Thr Thr Leu Ser Asp Gly Ala Thr Ala 
    290                 295                 300                 


Phe Glu Lys Cys Asp Pro Tyr Arg Glu Gly Tyr Ala Asp Cys Ala Thr 
305                 310                 315                 320 


Tyr Leu Ala Asp Val Glu Gln Ser Met Gly Leu Met Asn Ser Gly Ala 
                325                 330                 335     


Val Tyr Ala Leu Trp Asp Tyr Ser Ala Glu Phe Gly Asp Glu Leu Ser 
            340                 345                 350         


Phe Arg Glu Gly Glu Ser Val Thr Val Leu Arg Arg Asp Gly Pro Glu 
        355                 360                 365             


Glu Thr Asp Trp Trp Trp Ala Ala Leu His Gly Gln Glu Gly Tyr Val 
    370                 375                 380                 


Pro Arg Asn Tyr Phe Gly Leu Phe Pro Arg Val Lys Pro Gln Arg Ser 
385                 390                 395                 400 


Lys Val 
        


<210> 4722
<211> 496
<212> PRT
<213> Homo sapiens

<400> 4722
Met Asp Asp Val Pro Ala Pro Thr Pro Ala Pro Ala Pro Pro Ala Ala 
1               5                   10                  15      


Ala Ala Pro Arg Val Pro Phe His Cys Ser Glu Cys Gly Lys Ser Phe 
            20                  25                  30          


Arg Tyr Arg Ser Asp Leu Arg Arg His Phe Ala Arg His Thr Ala Leu 
        35                  40                  45              


Lys Pro His Ala Cys Pro Arg Cys Gly Lys Gly Phe Lys His Ser Phe 
    50                  55                  60                  


Asn Leu Ala Asn His Leu Arg Ser His Thr Gly Glu Arg Pro Tyr Arg 
65                  70                  75                  80  


Cys Ser Ala Cys Pro Lys Gly Phe Arg Asp Ser Thr Gly Leu Leu His 
                85                  90                  95      


His Gln Val Val His Thr Gly Glu Lys Pro Tyr Cys Cys Leu Val Cys 
            100                 105                 110         


Glu Leu Arg Phe Ser Ser Arg Ser Ser Leu Gly Arg His Leu Lys Arg 
        115                 120                 125             


Gln His Arg Gly Val Leu Pro Ser Pro Leu Gln Pro Gly Pro Gly Leu 
    130                 135                 140                 


Pro Ala Leu Ser Ala Pro Cys Ser Val Cys Cys Asn Val Gly Pro Cys 
145                 150                 155                 160 


Ser Val Cys Gly Gly Ser Gly Ala Gly Gly Gly Glu Gly Pro Glu Gly 
                165                 170                 175     


Ala Gly Ala Gly Leu Gly Ser Trp Gly Leu Ala Glu Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Ala Ser Leu Pro Pro Phe Ala Cys Gly Ala Cys Ala Arg Arg 
        195                 200                 205             


Phe Asp His Gly Arg Glu Leu Ala Ala His Trp Ala Ala His Thr Asp 
    210                 215                 220                 


Val Lys Pro Phe Lys Cys Pro Arg Cys Glu Arg Asp Phe Asn Ala Pro 
225                 230                 235                 240 


Ala Leu Leu Glu Arg His Lys Leu Thr His Asp Leu Gln Gly Pro Gly 
                245                 250                 255     


Ala Pro Pro Ala Gln Ala Trp Ala Ala Gly Pro Gly Ala Gly Pro Glu 
            260                 265                 270         


Thr Ala Gly Glu Gly Thr Ala Ala Glu Ala Gly Asp Ala Pro Leu Ala 
        275                 280                 285             


Ser Asp Arg Arg Leu Leu Leu Gly Pro Ala Gly Gly Gly Val Pro Lys 
    290                 295                 300                 


Leu Gly Gly Leu Leu Pro Glu Gly Gly Gly Glu Ala Pro Ala Pro Ala 
305                 310                 315                 320 


Ala Ala Ala Glu Pro Ser Glu Asp Thr Leu Tyr Gln Cys Asp Cys Gly 
                325                 330                 335     


Thr Phe Phe Ala Ser Ala Ala Ala Leu Ala Ser His Leu Glu Ala His 
            340                 345                 350         


Ser Gly Pro Ala Thr Tyr Gly Cys Gly His Cys Gly Ala Leu Tyr Ala 
        355                 360                 365             


Ala Leu Ala Ala Leu Glu Glu His Arg Arg Val Ser His Gly Glu Gly 
    370                 375                 380                 


Gly Gly Glu Glu Ala Ala Thr Ala Ala Arg Glu Arg Glu Pro Ala Ser 
385                 390                 395                 400 


Gly Glu Pro Pro Ser Gly Ser Gly Arg Gly Lys Lys Ile Phe Gly Cys 
                405                 410                 415     


Ser Glu Cys Glu Lys Leu Phe Arg Ser Pro Arg Asp Leu Glu Arg His 
            420                 425                 430         


Val Leu Val His Thr Gly Glu Lys Pro Phe Pro Cys Leu Glu Cys Gly 
        435                 440                 445             


Lys Phe Phe Arg His Glu Cys Tyr Leu Lys Arg His Arg Leu Leu His 
    450                 455                 460                 


Gly Thr Glu Arg Pro Phe Pro Cys His Ile Cys Gly Lys Gly Phe Ile 
465                 470                 475                 480 


Thr Leu Ser Asn Leu Ser Arg His Leu Lys Leu His Arg Gly Met Asp 
                485                 490                 495     


<210> 4723
<211> 657
<212> PRT
<213> Homo sapiens

<400> 4723
Met Ala Ser Ala Arg Lys Ala Ser Arg Pro Met Arg Asp Val Phe Gly 
1               5                   10                  15      


Asp Phe Ser Asp Val Ser Leu Glu Asp Ser Thr Met Glu Glu Ile Arg 
            20                  25                  30          


Asn Phe Gln Ile Ser Arg Asn Leu Thr Lys Ile Ala Pro Gly His Ser 
        35                  40                  45              


Arg Phe Leu Lys Arg Asn Gln Thr Leu Asp Glu Lys His Leu Leu Leu 
    50                  55                  60                  


Lys Glu Asn Pro Val Leu Gly Ser Gly Pro Arg Leu Ala Ser Cys Arg 
65                  70                  75                  80  


Pro Pro Thr Thr Ala Ser Arg Ile Arg Ala Asn Ala Ala Leu Met Lys 
                85                  90                  95      


Leu Ala Gln Leu Glu Thr Arg Ile Met Asn Arg Lys Leu Gln Arg Asn 
            100                 105                 110         


Leu Ser Asp Thr Glu Ser Asp Ser Met Thr Ala Asp Ala Gly Leu Pro 
        115                 120                 125             


Lys Arg Ala Asp Arg Ile Leu Ser Gly Gly Ala Leu Glu Leu Ala Ser 
    130                 135                 140                 


Gln Asn Thr Asp Lys Thr Ser Gln Asn Gln Ala Arg Glu Leu Pro Val 
145                 150                 155                 160 


Thr Glu Asn Asn Ala Gln Asn Ala Lys Val Ser Arg Phe Leu Lys Lys 
                165                 170                 175     


Lys Gln Ala Pro Val Glu Asn Ile Ser Pro Glu Ala Pro Ala Gly Lys 
            180                 185                 190         


Glu Arg Thr Leu Gln Thr Pro Lys Gln Lys Glu Pro Ala Arg Thr Phe 
        195                 200                 205             


Asp Ser Pro Asp Ser Asp Glu Glu Glu Met Lys Val Leu Leu Gly Ser 
    210                 215                 220                 


Leu Met Asp Ser Ser Arg Glu Lys Asn Thr Asn Gln Gly Phe Ser Ser 
225                 230                 235                 240 


Ala Asn Val Ser Glu Glu Glu Glu Arg Lys Leu Phe Ser Val Pro Ser 
                245                 250                 255     


Gln Leu Arg Ala Phe Thr Val Pro Ser Val Glu Leu Ser Ser Ala Lys 
            260                 265                 270         


Pro Ser Gln Thr Ser His Leu Pro Thr Ser Leu Ala Ala Asp Arg Thr 
        275                 280                 285             


Leu His Ser Thr Arg Ser Arg Ala Asp Tyr Pro Gln Ser His Val Ser 
    290                 295                 300                 


Ser Asp Thr Ala Ser His Thr Pro Ser Val Ser Ile Thr Gly Ala Phe 
305                 310                 315                 320 


Ser Asn Ser Val Ser Leu Lys Met Gly His Val Lys Leu Val Ser Ser 
                325                 330                 335     


Pro Gly Arg Ser Glu Ala Glu Thr Val Asp Glu Pro Val Ser Glu Gly 
            340                 345                 350         


Ala Asp Asp Ser Leu Asp Glu Phe Arg Ile Asn Ile Leu Ser Leu Asp 
        355                 360                 365             


Gly Leu Ala Pro Ala Val Ser Glu Asn Ser Asp Leu Glu Gln Glu Glu 
    370                 375                 380                 


Glu Ser Ala Gln Arg Gln Lys Thr Ala Gly Lys Ile Phe Arg Ala Glu 
385                 390                 395                 400 


Ala Ser Thr Gly Gln Asp Ala Pro Arg Gln Ala Gln Ala Arg Ser Trp 
                405                 410                 415     


Ala Ser Gln Gly Lys Ala Ala Ser Ala Glu Gly Asp Glu Ser Glu Val 
            420                 425                 430         


Ser Glu His Leu Ser Ala Ser Ser Ala Ser Ala Ile Gln Gln Asp Ser 
        435                 440                 445             


Thr Ser Ser Met Gln Pro Pro Ser Glu Ala Pro Met Val Asn Thr Val 
    450                 455                 460                 


Ser Ser Ala Tyr Ser Glu Asp Phe Glu Asn Ser Pro Ser Leu Thr Ala 
465                 470                 475                 480 


Ser Glu Pro Thr Ala His Ser Lys Glu Ser Leu Asp Arg Thr Leu Asp 
                485                 490                 495     


Ala Leu Ser Glu Ser Ser Ser Ser Val Lys Thr Asp Leu Pro Gln Thr 
            500                 505                 510         


Ala Glu Ser Arg Lys Lys Ser Gly Arg His Val Thr Arg Val Leu Val 
        515                 520                 525             


Lys Asp Thr Ala Val Gln Thr Pro Asp Pro Ala Phe Thr Tyr Glu Trp 
    530                 535                 540                 


Thr Lys Val Ala Ser Met Ala Ala Met Gly Pro Ala Leu Gly Gly Ala 
545                 550                 555                 560 


Tyr Val Asp Pro Thr Pro Ile Ala Asn His Val Ile Ser Ala Asp Ala 
                565                 570                 575     


Ile Glu Ala Leu Thr Ala Tyr Ser Pro Ala Val Leu Ala Leu His Asp 
            580                 585                 590         


Val Leu Lys Gln Gln Leu Ser Leu Thr Gln Gln Phe Ile Gln Ala Ser 
        595                 600                 605             


Arg His Leu His Ala Ser Leu Leu Arg Ser Leu Asp Ala Asp Ser Phe 
    610                 615                 620                 


His Tyr His Thr Leu Glu Glu Ala Lys Glu Tyr Ile Arg Cys His Arg 
625                 630                 635                 640 


Pro Ala Pro Leu Thr Met Glu Asp Ala Leu Glu Glu Val Asn Lys Glu 
                645                 650                 655     


Leu 
    


<210> 4724
<211> 125
<212> PRT
<213> Homo sapiens

<400> 4724
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu 
1               5                   10                  15      


Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala 
            20                  25                  30          


Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu 
        35                  40                  45              


Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro 
    50                  55                  60                  


Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr 
65                  70                  75                  80  


Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu 
                85                  90                  95      


Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn 
            100                 105                 110         


Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr 
        115                 120                 125 


<210> 4725
<211> 244
<212> PRT
<213> Homo sapiens

<400> 4725
Met Glu Val Thr Gly Val Ser Ala Pro Thr Val Thr Val Phe Ile Ser 
1               5                   10                  15      


Ser Ser Leu Asn Thr Phe Arg Ser Glu Lys Arg Tyr Ser Arg Ser Leu 
            20                  25                  30          


Thr Ile Ala Glu Phe Lys Cys Lys Leu Glu Leu Leu Val Gly Ser Pro 
        35                  40                  45              


Ala Ser Cys Met Glu Leu Glu Leu Tyr Gly Val Asp Asp Lys Phe Tyr 
    50                  55                  60                  


Ser Lys Leu Asp Gln Glu Asp Ala Leu Leu Gly Ser Tyr Pro Val Asp 
65                  70                  75                  80  


Asp Gly Cys Arg Ile His Val Ile Asp His Ser Gly Ala Arg Leu Gly 
                85                  90                  95      


Glu Tyr Glu Asp Val Ser Arg Val Glu Lys Tyr Thr Ile Ser Gln Glu 
            100                 105                 110         


Ala Tyr Asp Gln Arg Gln Asp Thr Val Arg Ser Phe Leu Lys Arg Ser 
        115                 120                 125             


Lys Leu Gly Arg Tyr Asn Glu Glu Glu Arg Ala Gln Gln Glu Ala Glu 
    130                 135                 140                 


Ala Ala Gln Arg Leu Ala Glu Glu Lys Ala Gln Ala Ser Ser Ile Pro 
145                 150                 155                 160 


Val Gly Ser Arg Cys Glu Val Arg Ala Ala Gly Gln Ser Pro Arg Arg 
                165                 170                 175     


Gly Thr Val Met Tyr Val Gly Leu Thr Asp Phe Lys Pro Gly Tyr Trp 
            180                 185                 190         


Ile Gly Val Arg Tyr Asp Glu Pro Leu Gly Lys Asn Asp Gly Ser Val 
        195                 200                 205             


Asn Gly Lys Arg Tyr Phe Glu Cys Gln Ala Lys Tyr Gly Ala Phe Val 
    210                 215                 220                 


Lys Pro Ala Val Val Thr Val Gly Asp Phe Pro Glu Glu Asp Tyr Gly 
225                 230                 235                 240 


Leu Asp Glu Ile 
                


<210> 4726
<211> 378
<212> PRT
<213> Homo sapiens

<400> 4726
Met Val Asp Tyr Ser Val Trp Asp His Ile Glu Val Ser Asp Asp Glu 
1               5                   10                  15      


Asp Glu Thr His Pro Asn Ile Asp Thr Ala Ser Leu Phe Arg Trp Arg 
            20                  25                  30          


His Gln Ala Arg Val Glu Arg Met Glu Gln Phe Gln Lys Glu Lys Glu 
        35                  40                  45              


Glu Leu Asp Arg Gly Cys Arg Glu Cys Lys Arg Lys Val Ala Glu Cys 
    50                  55                  60                  


Gln Arg Lys Leu Lys Glu Leu Glu Val Ala Glu Gly Gly Lys Ala Glu 
65                  70                  75                  80  


Leu Glu Arg Leu Gln Ala Glu Ala Gln Gln Leu Arg Lys Glu Glu Arg 
                85                  90                  95      


Ser Trp Glu Gln Lys Leu Glu Glu Met Arg Lys Lys Glu Lys Ser Met 
            100                 105                 110         


Pro Trp Asn Val Asp Thr Leu Ser Lys Asp Gly Phe Ser Lys Ser Met 
        115                 120                 125             


Val Asn Thr Lys Pro Glu Lys Thr Glu Glu Asp Ser Glu Glu Val Arg 
    130                 135                 140                 


Glu Gln Lys His Lys Thr Phe Val Glu Lys Tyr Glu Lys Gln Ile Lys 
145                 150                 155                 160 


His Phe Gly Met Leu Arg Arg Trp Asp Asp Ser Gln Lys Tyr Leu Ser 
                165                 170                 175     


Asp Asn Val His Leu Val Cys Glu Glu Thr Ala Asn Tyr Leu Val Ile 
            180                 185                 190         


Trp Cys Ile Asp Leu Glu Val Glu Glu Lys Cys Ala Leu Met Glu Gln 
        195                 200                 205             


Val Ala His Gln Thr Ile Val Met Gln Phe Ile Leu Glu Leu Ala Lys 
    210                 215                 220                 


Ser Leu Lys Val Asp Pro Arg Ala Cys Phe Arg Gln Phe Phe Thr Lys 
225                 230                 235                 240 


Ile Lys Thr Ala Asp Arg Gln Tyr Met Glu Gly Phe Asn Asp Glu Leu 
                245                 250                 255     


Glu Ala Phe Lys Glu Arg Val Arg Gly Arg Ala Lys Leu Arg Ile Glu 
            260                 265                 270         


Lys Ala Met Lys Glu Tyr Glu Glu Glu Glu Arg Lys Lys Arg Leu Gly 
        275                 280                 285             


Pro Gly Gly Leu Asp Pro Val Glu Val Tyr Glu Ser Leu Pro Glu Glu 
    290                 295                 300                 


Leu Gln Lys Cys Phe Asp Val Lys Asp Val Gln Met Leu Gln Asp Ala 
305                 310                 315                 320 


Ile Ser Lys Met Asp Pro Thr Asp Ala Lys Tyr His Met Gln Arg Cys 
                325                 330                 335     


Ile Asp Ser Gly Leu Trp Val Pro Asn Ser Lys Ala Ser Glu Ala Lys 
            340                 345                 350         


Glu Gly Glu Glu Ala Gly Pro Gly Asp Pro Leu Leu Glu Ala Val Pro 
        355                 360                 365             


Lys Thr Gly Asp Glu Lys Asp Val Ser Val 
    370                 375             


<210> 4727
<211> 483
<212> PRT
<213> Homo sapiens

<400> 4727
Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg 
1               5                   10                  15      


Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly 
        35                  40                  45              


Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser 
    50                  55                  60                  


Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp 
                85                  90                  95      


Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu 
            100                 105                 110         


Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly 
        115                 120                 125             


Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu 
    130                 135                 140                 


Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu 
145                 150                 155                 160 


Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg 
                165                 170                 175     


Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn 
            180                 185                 190         


Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His 
        195                 200                 205             


Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr 
    210                 215                 220                 


Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val 
225                 230                 235                 240 


Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr 
                245                 250                 255     


Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg 
            260                 265                 270         


Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro 
        275                 280                 285             


Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp 
    290                 295                 300                 


Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe 
305                 310                 315                 320 


Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu 
                325                 330                 335     


Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr 
            340                 345                 350         


Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe 
        355                 360                 365             


Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu 
    370                 375                 380                 


Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His 
385                 390                 395                 400 


Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn 
                405                 410                 415     


Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile 
            420                 425                 430         


Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro 
        435                 440                 445             


Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr 
    450                 455                 460                 


Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr 
465                 470                 475                 480 


Asn Ser Ser 
            


<210> 4728
<211> 320
<212> PRT
<213> Homo sapiens

<400> 4728
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu 
1               5                   10                  15      


Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly 
            20                  25                  30          


Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser 
        35                  40                  45              


Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys 
    50                  55                  60                  


Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile 
65                  70                  75                  80  


Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp 
                85                  90                  95      


Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu 
            100                 105                 110         


Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro 
        115                 120                 125             


Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu 
    130                 135                 140                 


His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser 
145                 150                 155                 160 


Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln 
                165                 170                 175     


Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val 
            180                 185                 190         


Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu 
        195                 200                 205             


Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys 
    210                 215                 220                 


His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala 
225                 230                 235                 240 


Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe 
                245                 250                 255     


Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn 
            260                 265                 270         


Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile 
        275                 280                 285             


Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg 
    290                 295                 300                 


Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
305                 310                 315                 320 


<210> 4729
<211> 148
<212> PRT
<213> Homo sapiens

<400> 4729
Met Ala Glu Ser Asp Trp Asp Thr Val Thr Val Leu Arg Lys Lys Gly 
1               5                   10                  15      


Pro Thr Ala Ala Gln Ala Lys Ser Lys Gln Ala Ile Leu Ala Ala Gln 
            20                  25                  30          


Arg Arg Gly Glu Asp Val Glu Thr Ser Lys Lys Trp Ala Ala Gly Gln 
        35                  40                  45              


Asn Lys Gln His Ser Ile Thr Lys Asn Thr Ala Lys Leu Asp Arg Glu 
    50                  55                  60                  


Thr Glu Glu Leu His His Asp Arg Val Thr Leu Glu Val Gly Lys Val 
65                  70                  75                  80  


Ile Gln Gln Gly Arg Gln Ser Lys Gly Leu Thr Gln Lys Asp Leu Ala 
                85                  90                  95      


Thr Lys Ile Asn Glu Lys Pro Gln Val Ile Ala Asp Tyr Glu Ser Gly 
            100                 105                 110         


Arg Ala Ile Pro Asn Asn Gln Val Leu Gly Lys Ile Glu Arg Ala Ile 
        115                 120                 125             


Gly Leu Lys Leu Arg Gly Lys Asp Ile Gly Lys Pro Ile Glu Lys Gly 
    130                 135                 140                 


Pro Arg Ala Lys 
145             


<210> 4730
<211> 518
<212> PRT
<213> Homo sapiens

<400> 4730
Met Ala Phe Trp Ala Gly Gly Ser Pro Ser Val Val Asp Tyr Phe Pro 
1               5                   10                  15      


Ser Glu Asp Phe Tyr Arg Cys Gly Tyr Cys Lys Asn Glu Ser Gly Ser 
            20                  25                  30          


Arg Ser Asn Gly Met Trp Ala His Ser Met Thr Val Gln Asp Tyr Gln 
        35                  40                  45              


Asp Leu Ile Asp Arg Gly Trp Arg Arg Ser Gly Lys Tyr Val Tyr Lys 
    50                  55                  60                  


Pro Val Met Asn Gln Thr Cys Cys Pro Gln Tyr Thr Ile Arg Cys Arg 
65                  70                  75                  80  


Pro Leu Gln Phe Gln Pro Ser Lys Ser His Lys Lys Val Leu Lys Lys 
                85                  90                  95      


Met Leu Lys Phe Leu Ala Lys Gly Glu Val Pro Lys Gly Ser Cys Glu 
            100                 105                 110         


Asp Glu Pro Met Asp Ser Thr Met Asp Asp Ala Val Ala Gly Asp Phe 
        115                 120                 125             


Ala Leu Ile Asn Lys Leu Asp Ile Gln Cys Asp Leu Lys Thr Leu Ser 
    130                 135                 140                 


Asp Asp Ile Lys Glu Ser Leu Glu Ser Glu Gly Lys Asn Ser Lys Lys 
145                 150                 155                 160 


Glu Glu Pro Gln Glu Leu Leu Gln Ser Gln Asp Phe Val Gly Glu Lys 
                165                 170                 175     


Leu Gly Ser Gly Glu Pro Ser His Ser Val Lys Val His Thr Val Pro 
            180                 185                 190         


Lys Pro Gly Lys Gly Ala Asp Leu Ser Lys Pro Pro Cys Arg Lys Ala 
        195                 200                 205             


Lys Glu Ile Arg Lys Glu Arg Lys Arg Leu Lys Leu Met Gln Gln Asn 
    210                 215                 220                 


Pro Ala Gly Glu Leu Glu Gly Phe Gln Ala Gln Gly His Pro Pro Ser 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Ala Lys Ser Asn Gln Pro Lys Ser Leu Glu Asp 
                245                 250                 255     


Leu Ile Phe Glu Ser Leu Pro Glu Asn Ala Ser His Lys Leu Glu Val 
            260                 265                 270         


Arg Val Val Arg Ser Ser Pro Pro Ser Ser Gln Phe Lys Ala Thr Leu 
        275                 280                 285             


Leu Glu Ser Tyr Gln Val Tyr Lys Arg Tyr Gln Met Val Ile His Lys 
    290                 295                 300                 


Asn Pro Pro Asp Thr Pro Thr Glu Ser Gln Phe Thr Arg Phe Leu Cys 
305                 310                 315                 320 


Ser Ser Pro Leu Glu Ala Glu Thr Pro Pro Asn Gly Pro Asp Cys Gly 
                325                 330                 335     


Tyr Gly Ser Phe His Gln Gln Tyr Trp Leu Asp Gly Lys Ile Ile Ala 
            340                 345                 350         


Val Gly Val Ile Asp Ile Leu Pro Asn Cys Val Ser Ser Val Tyr Leu 
        355                 360                 365             


Tyr Tyr Asp Pro Asp Tyr Ser Phe Leu Ser Leu Gly Val Tyr Ser Ala 
    370                 375                 380                 


Leu Arg Glu Ile Ala Phe Thr Arg Gln Leu His Glu Lys Thr Ser Gln 
385                 390                 395                 400 


Leu Ser Tyr Tyr Tyr Met Gly Phe Tyr Ile His Ser Cys Pro Lys Met 
                405                 410                 415     


Lys Tyr Lys Gly Gln Tyr Arg Pro Ser Asp Leu Leu Cys Pro Glu Thr 
            420                 425                 430         


Tyr Val Trp Val Pro Ile Glu Gln Cys Leu Pro Ser Leu Glu Asn Ser 
        435                 440                 445             


Lys Tyr Cys Arg Phe Asn Gln Asp Pro Glu Ala Val Asp Glu Asp Arg 
    450                 455                 460                 


Ser Thr Glu Pro Asp Arg Leu Gln Val Phe His Lys Arg Ala Ile Met 
465                 470                 475                 480 


Pro Tyr Gly Val Tyr Lys Lys Gln Gln Lys Asp Pro Ser Glu Glu Ala 
                485                 490                 495     


Ala Val Leu Gln Tyr Ala Ser Leu Val Gly Gln Lys Cys Ser Glu Arg 
            500                 505                 510         


Met Leu Leu Phe Arg Asn 
        515             


<210> 4731
<211> 300
<212> PRT
<213> Homo sapiens

<400> 4731
Met Glu Pro Pro Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly Ala 
1               5                   10                  15      


Val Arg Phe Leu Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His Val 
            20                  25                  30          


Leu Asn Arg Val Pro Leu Arg Gln Leu Leu Arg Leu Gln Arg Val Ser 
        35                  40                  45              


Arg Ala Phe Arg Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg Arg 
    50                  55                  60                  


Phe Asp Ala Ala Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu Ala 
65                  70                  75                  80  


Arg Leu Leu Arg Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala Pro 
                85                  90                  95      


Cys His Glu Trp Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala Arg 
            100                 105                 110         


Asn Pro Gln Leu Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu Ser 
        115                 120                 125             


Arg Arg Ala Leu Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln Arg 
    130                 135                 140                 


Leu Ser Leu Ala His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg Gly 
145                 150                 155                 160 


Leu Ala Asp Arg Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala Cys 
                165                 170                 175     


Arg Gln Leu Lys Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg Arg Gly 
            180                 185                 190         


Ala Gly Leu Arg Ser Leu Ser Leu Ala Val Asn Ala Asn Val Gly Asp 
        195                 200                 205             


Ala Ala Val Gln Glu Leu Ala Arg Asn Cys Pro Glu Leu His His Leu 
    210                 215                 220                 


Asp Leu Thr Gly Cys Leu Arg Val Gly Ser Asp Gly Val Arg Thr Leu 
225                 230                 235                 240 


Ala Glu Tyr Cys Pro Val Leu Arg Ser Leu Arg Val Arg His Cys His 
                245                 250                 255     


His Val Ala Glu Ser Ser Leu Ser Arg Leu Arg Lys Arg Gly Val Asp 
            260                 265                 270         


Ile Asp Val Glu Pro Pro Leu His Gln Ala Leu Val Leu Leu Gln Asp 
        275                 280                 285             


Met Ala Gly Phe Ala Pro Phe Val Asn Leu Gln Val 
    290                 295                 300 


<210> 4732
<211> 478
<212> PRT
<213> Homo sapiens

<400> 4732
Met Ala Ala Arg Pro Ile Thr Leu Gly Ile Asp Leu Gly Thr Thr Ser 
1               5                   10                  15      


Val Lys Ala Ala Leu Leu Arg Ala Ala Pro Asp Asp Pro Ser Gly Phe 
            20                  25                  30          


Ala Val Leu Ala Ser Cys Ala Arg Ala Ala Arg Ala Glu Ala Ala Val 
        35                  40                  45              


Glu Ser Ala Val Ala Gly Pro Gln Gly Arg Glu Gln Asp Val Ser Arg 
    50                  55                  60                  


Ile Leu Gln Ala Leu His Glu Cys Leu Ala Ala Leu Pro Arg Pro Gln 
65                  70                  75                  80  


Leu Arg Ser Val Val Gly Ile Gly Val Ser Gly Gln Met His Gly Val 
                85                  90                  95      


Val Phe Trp Lys Thr Gly Gln Gly Cys Glu Trp Thr Glu Gly Gly Ile 
            100                 105                 110         


Thr Pro Val Phe Glu Pro Arg Ala Val Ser His Leu Val Thr Trp Gln 
        115                 120                 125             


Asp Gly Arg Cys Ser Ser Glu Phe Leu Ala Ser Leu Pro Gln Pro Lys 
    130                 135                 140                 


Ser His Leu Ser Val Ala Thr Gly Phe Gly Cys Ala Thr Ile Phe Trp 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Pro Glu Phe Leu Lys Ser Tyr Asp Ala Ala Gly 
                165                 170                 175     


Thr Ile His Asp Tyr Val Val Ala Met Leu Cys Gly Leu Pro Arg Pro 
            180                 185                 190         


Leu Met Ser Asp Gln Asn Ala Ala Ser Trp Gly Tyr Phe Asn Thr Gln 
        195                 200                 205             


Ser Gln Ser Trp Asn Val Glu Thr Leu Arg Ser Ser Gly Phe Pro Val 
    210                 215                 220                 


His Leu Leu Pro Asp Ile Ala Glu Pro Gly Ser Val Ala Gly Arg Thr 
225                 230                 235                 240 


Ser His Met Trp Phe Glu Ile Pro Lys Gly Thr Gln Val Gly Val Ala 
                245                 250                 255     


Leu Gly Asp Leu Gln Ala Ser Val Tyr Ser Cys Met Ala Gln Arg Thr 
            260                 265                 270         


Asp Ala Val Leu Asn Ile Ser Thr Ser Val Gln Leu Ala Ala Ser Met 
        275                 280                 285             


Pro Ser Gly Phe Gln Pro Ala Gln Thr Pro Asp Pro Thr Ala Pro Val 
    290                 295                 300                 


Ala Tyr Phe Pro Tyr Phe Asn Arg Thr Tyr Leu Gly Val Ala Ala Ser 
305                 310                 315                 320 


Leu Asn Gly Gly Asn Val Leu Ala Thr Phe Val His Met Leu Val Gln 
                325                 330                 335     


Trp Met Ala Asp Leu Gly Leu Glu Val Glu Glu Ser Thr Val Tyr Ser 
            340                 345                 350         


Arg Met Ile Gln Ala Ala Val Gln Gln Arg Asp Thr His Leu Thr Ile 
        355                 360                 365             


Thr Pro Thr Val Leu Gly Glu Arg His Leu Pro Asp Gln Leu Ala Ser 
    370                 375                 380                 


Val Thr Arg Ile Ser Ser Ser Asp Leu Ser Leu Gly His Val Thr Arg 
385                 390                 395                 400 


Ala Leu Cys Arg Gly Ile Val Gln Asn Leu His Ser Met Leu Pro Ile 
                405                 410                 415     


Gln Gln Leu Gln Asp Trp Gly Val Glu Arg Val Met Gly Ser Gly Ser 
            420                 425                 430         


Ala Leu Ser Arg Asn Asp Val Leu Lys Gln Glu Val Gln Arg Ala Phe 
        435                 440                 445             


Pro Leu Pro Met Ser Phe Gly Gln Asp Val Asp Ala Ala Val Gly Ala 
    450                 455                 460                 


Ala Leu Val Met Leu Arg Arg His Leu Asn Gln Lys Glu Ser 
465                 470                 475             


<210> 4733
<211> 124
<212> PRT
<213> Homo sapiens

<400> 4733
Met Ser Tyr Ile Pro Gly Gln Pro Val Thr Ala Val Val Gln Arg Val 
1               5                   10                  15      


Glu Ile His Lys Leu Arg Gln Gly Glu Asn Leu Ile Leu Gly Phe Ser 
            20                  25                  30          


Ile Gly Gly Gly Ile Asp Gln Asp Pro Ser Gln Asn Pro Phe Ser Glu 
        35                  40                  45              


Asp Lys Thr Asp Lys Gly Ile Tyr Val Thr Arg Val Ser Glu Gly Gly 
    50                  55                  60                  


Pro Ala Glu Ile Ala Gly Leu Gln Ile Gly Asp Lys Ile Met Gln Val 
65                  70                  75                  80  


Asn Gly Trp Asp Met Thr Met Val Thr His Asp Gln Ala Arg Lys Arg 
                85                  90                  95      


Leu Thr Lys Arg Ser Glu Glu Val Val Arg Leu Leu Val Thr Arg Gln 
            100                 105                 110         


Ser Leu Gln Lys Ala Val Gln Gln Ser Met Leu Ser 
        115                 120                 


<210> 4734
<211> 185
<212> PRT
<213> Homo sapiens

<400> 4734
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Thr Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Thr Ala His Glu Thr Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly 
            100                 105                 110         


Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Thr Asp Ser 
        115                 120                 125             


Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asn Ser Asp Glu Ala 
    130                 135                 140                 


Asp Leu Val Pro Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Val Val 
145                 150                 155                 160 


Ile Ser Phe Tyr Glu Glu Arg Leu Thr Trp His Ser Tyr Pro Ser Glu 
                165                 170                 175     


Asp Asp Asp Lys Lys Asp Asp Lys Asn 
            180                 185 


<210> 4735
<211> 366
<212> PRT
<213> Homo sapiens

<400> 4735
Met Ala Glu Leu Gln Gln Leu Gln Glu Phe Glu Ile Pro Thr Gly Arg 
1               5                   10                  15      


Glu Ala Leu Arg Gly Asn His Ser Ala Leu Leu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asp Asn Tyr Val Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Met Ala Phe Thr Thr Gln Ala Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Val Gly Asn Leu Ala Gly His Thr Leu Arg Met Leu Asp Leu Gln Gly 
65                  70                  75                  80  


Ala Ala Leu Arg Gln Val Glu Ala Arg Val Ser Thr Leu Gly Gln Met 
                85                  90                  95      


Val Asn Met His Met Glu Lys Val Ala Arg Arg Glu Ile Gly Thr Leu 
            100                 105                 110         


Ala Thr Val Gln Arg Leu Pro Pro Gly Gln Lys Val Ile Ala Pro Glu 
        115                 120                 125             


Asn Leu Pro Pro Leu Thr Pro Tyr Cys Arg Arg Pro Leu Asn Phe Gly 
    130                 135                 140                 


Cys Leu Asp Asp Ile Gly His Gly Ile Lys Asp Leu Ser Thr Gln Leu 
145                 150                 155                 160 


Ser Arg Thr Gly Thr Leu Ser Arg Lys Ser Ile Lys Ala Pro Ala Thr 
                165                 170                 175     


Pro Ala Ser Ala Thr Leu Gly Arg Pro Pro Arg Ile Pro Glu Pro Val 
            180                 185                 190         


His Leu Pro Val Val Pro Asp Gly Arg Leu Ser Ala Ala Ser Ser Ala 
        195                 200                 205             


Phe Ser Leu Ala Ser Ala Gly Ser Ala Glu Gly Val Gly Gly Ala Pro 
    210                 215                 220                 


Thr Pro Lys Gly Gln Ala Ala Pro Pro Ala Pro Pro Leu Pro Ser Ser 
225                 230                 235                 240 


Leu Asp Pro Pro Pro Pro Pro Ala Ala Val Glu Val Phe Gln Arg Pro 
                245                 250                 255     


Pro Thr Leu Glu Glu Leu Ser Pro Pro Pro Pro Asp Glu Glu Leu Pro 
            260                 265                 270         


Leu Pro Leu Asp Leu Pro Pro Pro Pro Pro Leu Asp Gly Asp Glu Leu 
        275                 280                 285             


Gly Leu Pro Pro Pro Pro Pro Gly Phe Gly Pro Asp Glu Pro Ser Trp 
    290                 295                 300                 


Val Pro Ala Ser Tyr Leu Glu Lys Val Val Thr Leu Tyr Pro Tyr Thr 
305                 310                 315                 320 


Ser Gln Lys Asp Asn Glu Leu Ser Phe Ser Glu Gly Thr Val Ile Cys 
                325                 330                 335     


Val Thr Arg Arg Tyr Ser Asp Gly Trp Cys Glu Gly Val Ser Ser Glu 
            340                 345                 350         


Gly Thr Gly Phe Phe Pro Gly Asn Tyr Val Glu Pro Ser Cys 
        355                 360                 365     


<210> 4736
<211> 186
<212> PRT
<213> Homo sapiens

<400> 4736
Met Glu Pro Thr Arg Asp Cys Pro Leu Phe Gly Gly Ala Phe Ser Ala 
1               5                   10                  15      


Ile Leu Pro Met Gly Ala Ile Asp Val Ser Asp Leu Arg Pro Val Pro 
            20                  25                  30          


Asp Asn Gln Glu Val Phe Cys His Pro Val Thr Asp Gln Ser Leu Ile 
        35                  40                  45              


Val Glu Leu Leu Glu Leu Gln Ala His Val Arg Gly Glu Ala Ala Ala 
    50                  55                  60                  


Arg Tyr His Phe Glu Asp Val Gly Gly Val Gln Gly Ala Arg Ala Val 
65                  70                  75                  80  


His Val Glu Ser Val Gln Pro Leu Ser Leu Glu Asn Leu Ala Leu Arg 
                85                  90                  95      


Gly Arg Cys Gln Glu Ala Trp Val Leu Ser Gly Lys Gln Gln Ile Ala 
            100                 105                 110         


Lys Glu Asn Gln Gln Val Ala Lys Asp Val Thr Leu His Gln Ala Leu 
        115                 120                 125             


Leu Arg Leu Pro Gln Tyr Gln Thr Asp Leu Leu Leu Thr Phe Asn Gln 
    130                 135                 140                 


Pro Pro Pro Asp Asn Arg Ser Ser Leu Gly Pro Glu Asn Leu Ser Pro 
145                 150                 155                 160 


Ala Pro Trp Ser Leu Gly Asp Phe Glu Gln Leu Val Thr Ser Leu Thr 
                165                 170                 175     


Leu His Asp Pro Asn Ile Phe Gly Pro Gln 
            180                 185     


<210> 4737
<211> 519
<212> PRT
<213> Homo sapiens

<400> 4737
Met Phe Leu Leu Pro Leu Pro Ala Ala Gly Arg Val Val Val Arg Arg 
1               5                   10                  15      


Leu Ala Val Arg Arg Phe Gly Ser Arg Ser Leu Ser Thr Ala Asp Met 
            20                  25                  30          


Thr Lys Gly Leu Val Leu Gly Ile Tyr Ser Lys Glu Lys Glu Asp Asp 
        35                  40                  45              


Val Pro Gln Phe Thr Ser Ala Gly Glu Asn Phe Asp Lys Leu Leu Ala 
    50                  55                  60                  


Gly Lys Leu Arg Glu Thr Leu Asn Ile Ser Gly Pro Pro Leu Lys Ala 
65                  70                  75                  80  


Gly Lys Thr Arg Thr Phe Tyr Gly Leu His Gln Asp Phe Pro Ser Val 
                85                  90                  95      


Val Leu Val Gly Leu Gly Lys Lys Ala Ala Gly Ile Asp Glu Gln Glu 
            100                 105                 110         


Asn Trp His Glu Gly Lys Glu Asn Ile Arg Ala Ala Val Ala Ala Gly 
        115                 120                 125             


Cys Arg Gln Ile Gln Asp Leu Glu Leu Ser Ser Val Glu Val Asp Pro 
    130                 135                 140                 


Cys Gly Asp Ala Gln Ala Ala Ala Glu Gly Ala Val Leu Gly Leu Tyr 
145                 150                 155                 160 


Glu Tyr Asp Asp Leu Lys Gln Lys Lys Lys Met Ala Val Ser Ala Lys 
                165                 170                 175     


Leu Tyr Gly Ser Gly Asp Gln Glu Ala Trp Gln Lys Gly Val Leu Phe 
            180                 185                 190         


Ala Ser Gly Gln Asn Leu Ala Arg Gln Leu Met Glu Thr Pro Ala Asn 
        195                 200                 205             


Glu Met Thr Pro Thr Arg Phe Ala Glu Ile Ile Glu Lys Asn Leu Lys 
    210                 215                 220                 


Ser Ala Ser Ser Lys Thr Glu Val His Ile Arg Pro Lys Ser Trp Ile 
225                 230                 235                 240 


Glu Glu Gln Ala Met Gly Ser Phe Leu Ser Val Ala Lys Gly Ser Asp 
                245                 250                 255     


Glu Pro Pro Val Phe Leu Glu Ile His Tyr Lys Gly Ser Pro Asn Ala 
            260                 265                 270         


Asn Glu Pro Pro Leu Val Phe Val Gly Lys Gly Ile Thr Phe Asp Ser 
        275                 280                 285             


Gly Gly Ile Ser Ile Lys Ala Ser Ala Asn Met Asp Leu Met Arg Ala 
    290                 295                 300                 


Asp Met Gly Gly Ala Ala Thr Ile Cys Ser Ala Ile Val Ser Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Leu Pro Ile Asn Ile Ile Gly Leu Ala Pro Leu Cys Glu 
                325                 330                 335     


Asn Met Pro Ser Gly Lys Ala Asn Lys Pro Gly Asp Val Val Arg Ala 
            340                 345                 350         


Lys Asn Gly Lys Thr Ile Gln Val Asp Asn Thr Asp Ala Glu Gly Arg 
        355                 360                 365             


Leu Ile Leu Ala Asp Ala Leu Cys Tyr Ala His Thr Phe Asn Pro Lys 
    370                 375                 380                 


Val Ile Leu Asn Ala Ala Thr Leu Thr Gly Ala Met Asp Val Ala Leu 
385                 390                 395                 400 


Gly Ser Gly Ala Thr Gly Val Phe Thr Asn Ser Ser Trp Leu Trp Asn 
                405                 410                 415     


Lys Leu Phe Glu Ala Ser Ile Glu Thr Gly Asp Arg Val Trp Arg Met 
            420                 425                 430         


Pro Leu Phe Glu His Tyr Thr Arg Gln Val Val Asp Cys Gln Leu Ala 
        435                 440                 445             


Asp Val Asn Asn Ile Gly Lys Tyr Arg Ser Ala Gly Ala Cys Thr Ala 
    450                 455                 460                 


Ala Ala Phe Leu Lys Glu Phe Val Thr His Pro Lys Trp Ala His Leu 
465                 470                 475                 480 


Asp Ile Ala Gly Val Met Thr Asn Lys Asp Glu Val Pro Tyr Leu Arg 
                485                 490                 495     


Lys Gly Met Thr Gly Arg Pro Thr Arg Thr Leu Ile Glu Phe Leu Leu 
            500                 505                 510         


Arg Phe Ser Gln Asp Asn Ala 
        515                 


<210> 4738
<211> 842
<212> PRT
<213> Homo sapiens

<400> 4738
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg Tyr Asp Leu Asn 
    130                 135                 140                 


Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu Glu Phe Lys Glu 
145                 150                 155                 160 


Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu Arg Val Leu Glu 
                165                 170                 175     


Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His Ala Ile Glu Thr 
            180                 185                 190         


Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val Val Cys Asp Val 
        195                 200                 205             


Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met Val Phe Cys Asp 
    210                 215                 220                 


Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val 
225                 230                 235                 240 


Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu Gly Val Gln Pro 
                245                 250                 255     


Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met Lys Pro Thr Arg 
            260                 265                 270         


Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu Trp Ile Pro Glu 
        275                 280                 285             


Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile Thr Lys Val Ser 
    290                 295                 300                 


His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser Leu Cys Asn Glu 
305                 310                 315                 320 


Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn Cys Arg Thr Ala 
                325                 330                 335     


Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu Met Lys Thr Ile 
            340                 345                 350         


Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr Cys Pro Lys His 
        355                 360                 365             


Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys Gly Ala Ala Gln 
    370                 375                 380                 


Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro Leu Glu Pro Phe 
385                 390                 395                 400 


Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg Val Ser Val Arg 
                405                 410                 415     


Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr Thr Phe Val Asn 
            420                 425                 430         


Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu Glu Val Val Asp 
        435                 440                 445             


Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val Asn Phe Asn Lys 
    450                 455                 460                 


Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn Leu Ala Lys Arg 
465                 470                 475                 480 


Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe Thr His Leu Arg 
                485                 490                 495     


Gln Asp Leu Glu Arg Val Arg Asn Leu Thr Tyr Met Val Thr Arg Arg 
            500                 505                 510         


Glu Lys Ile Lys Arg Ser Val Cys Lys Val Gln Glu Gln Ile Phe Asn 
        515                 520                 525             


Leu Tyr Thr Lys Leu Leu Glu Gln Glu Arg Val Ser Gly Val Pro Ser 
    530                 535                 540                 


Ser Cys Ser Ser Ser Ser Leu Glu Asn Met Leu Leu Phe Asn Ser Pro 
545                 550                 555                 560 


Ser Val Gly Pro Asp Ala Pro Lys Ile Glu Asp Leu Lys Trp His Ser 
                565                 570                 575     


Ala Phe Phe Arg Lys Gln Met Gly Thr Ser Leu Val His Ser Leu Lys 
            580                 585                 590         


Lys Pro His Lys Arg Asp Pro Leu Gln Asn Ser Pro Gly Ser Glu Gly 
        595                 600                 605             


Lys Thr Leu Leu Lys Gln Pro Asp Leu Cys Gly Arg Arg Glu Gly Met 
    610                 615                 620                 


Val Val Pro Glu Ser Phe Leu Gly Leu Glu Lys Thr Phe Ala Glu Ala 
625                 630                 635                 640 


Arg Leu Ile Ser Ala Gln Gln Lys Asn Gly Val Val Met Pro Asp His 
                645                 650                 655     


Gly Lys Arg Arg Asp Asn Arg Phe His Cys Asp Leu Ile Lys Gly Asp 
            660                 665                 670         


Leu Lys Asp Lys Ser Phe Lys Gln Ser His Lys Pro Leu Arg Ser Thr 
        675                 680                 685             


Asp Val Ser Gln Arg His Leu Asp Asn Thr Arg Ala Ala Thr Ser Pro 
    690                 695                 700                 


Gly Val Gly Gln Ser Ala Pro Gly Thr Arg Lys Glu Ile Val Pro Lys 
705                 710                 715                 720 


Cys Asn Gly Ser Leu Ile Lys Val Asn Tyr Asn Gln Thr Ala Val Lys 
                725                 730                 735     


Val Pro Thr Thr Pro Ala Ser Pro Val Lys Asn Trp Gly Gly Phe Arg 
            740                 745                 750         


Ile Pro Lys Lys Gly Glu Arg Gln Gln Gln Gly Glu Ala His Asp Gly 
        755                 760                 765             


Ala Cys His Gln His Ser Asp Tyr Pro Tyr Leu Gly Leu Gly Arg Val 
    770                 775                 780                 


Pro Ala Lys Glu Arg Ala Lys Ser Lys Leu Lys Ser Asp Asn Glu Asn 
785                 790                 795                 800 


Asp Gly Tyr Val Pro Asp Val Glu Met Ser Asp Ser Glu Ser Glu Ala 
                805                 810                 815     


Ser Glu Lys Lys Cys Ile His Thr Ser Ser Thr Ile Ser Arg Arg Thr 
            820                 825                 830         


Asp Ile Ile Arg Arg Ser Ile Leu Ala Ser 
        835                 840         


<210> 4739
<211> 294
<212> PRT
<213> Homo sapiens

<400> 4739
Met Asn Ser Glu Leu Asp Tyr Tyr Glu Lys Phe Glu Glu Val His Gly 
1               5                   10                  15      


Ile Leu Met Tyr Lys Asp Phe Val Lys Tyr Trp Asp Asn Val Glu Ala 
            20                  25                  30          


Phe Gln Ala Arg Pro Asp Asp Leu Val Ile Ala Thr Tyr Pro Lys Ser 
        35                  40                  45              


Gly Thr Thr Trp Val Ser Glu Ile Val Tyr Met Ile Tyr Lys Glu Gly 
    50                  55                  60                  


Asp Val Glu Lys Cys Lys Glu Asp Val Ile Phe Asn Arg Ile Pro Phe 
65                  70                  75                  80  


Leu Glu Cys Arg Lys Glu Asn Leu Met Asn Gly Val Lys Gln Leu Asp 
                85                  90                  95      


Glu Met Asn Ser Pro Arg Ile Val Lys Thr His Leu Pro Pro Glu Leu 
            100                 105                 110         


Leu Pro Ala Ser Phe Trp Glu Lys Asp Cys Lys Ile Ile Tyr Leu Cys 
        115                 120                 125             


Arg Asn Ala Lys Asp Val Ala Val Ser Phe Tyr Tyr Phe Phe Leu Met 
    130                 135                 140                 


Val Ala Gly His Pro Asn Pro Gly Ser Phe Pro Glu Phe Val Glu Lys 
145                 150                 155                 160 


Phe Met Gln Gly Gln Val Pro Tyr Gly Ser Trp Tyr Lys His Val Lys 
                165                 170                 175     


Ser Trp Trp Glu Lys Gly Lys Ser Pro Arg Val Leu Phe Leu Phe Tyr 
            180                 185                 190         


Glu Asp Leu Lys Glu Asp Ile Arg Lys Glu Val Ile Lys Leu Ile His 
        195                 200                 205             


Phe Leu Glu Arg Lys Pro Ser Glu Glu Leu Val Asp Arg Ile Ile His 
    210                 215                 220                 


His Thr Ser Phe Gln Glu Met Lys Asn Asn Pro Ser Thr Asn Tyr Thr 
225                 230                 235                 240 


Thr Leu Pro Asp Glu Ile Met Asn Gln Lys Leu Ser Pro Phe Met Arg 
                245                 250                 255     


Lys Gly Ile Thr Gly Asp Trp Lys Asn His Phe Thr Val Ala Leu Asn 
            260                 265                 270         


Glu Lys Phe Asp Lys His Tyr Glu Gln Gln Met Lys Glu Ser Thr Leu 
        275                 280                 285             


Lys Phe Arg Thr Glu Ile 
    290                 


<210> 4740
<211> 151
<212> PRT
<213> Homo sapiens

<400> 4740
Met Ser Ile Pro Phe Ser Asn Thr His Tyr Arg Ile Pro Gln Gly Phe 
1               5                   10                  15      


Gly Asn Leu Leu Glu Gly Leu Thr Arg Glu Ile Leu Arg Glu Gln Pro 
            20                  25                  30          


Asp Asn Ile Pro Ala Phe Ala Ala Ala Tyr Phe Glu Ser Leu Leu Glu 
        35                  40                  45              


Lys Arg Glu Lys Thr Asn Phe Asp Pro Ala Glu Trp Gly Ser Lys Val 
    50                  55                  60                  


Glu Asp Arg Phe Tyr Asn Asn His Ala Phe Glu Glu Gln Glu Pro Pro 
65                  70                  75                  80  


Glu Lys Ser Asp Pro Lys Gln Glu Glu Ser Gln Ile Ser Gly Lys Glu 
                85                  90                  95      


Glu Glu Thr Ser Val Thr Ile Leu Asp Ser Ser Glu Glu Asp Lys Glu 
            100                 105                 110         


Lys Glu Glu Val Ala Ala Val Lys Ile Gln Ala Ala Phe Arg Gly His 
        115                 120                 125             


Ile Ala Arg Glu Glu Ala Lys Lys Met Lys Thr Asn Ser Leu Gln Asn 
    130                 135                 140                 


Glu Glu Lys Glu Glu Asn Lys 
145                 150     


<210> 4741
<211> 459
<212> PRT
<213> Homo sapiens

<400> 4741
Met Ala Ala Ser Gly Ala Val Glu Pro Gly Pro Pro Gly Ala Ala Val 
1               5                   10                  15      


Ala Pro Ser Pro Ala Pro Ala Pro Pro Pro Ala Pro Asp His Leu Phe 
            20                  25                  30          


Arg Pro Ile Ser Ala Glu Asp Glu Glu Gln Gln Pro Thr Glu Ile Glu 
        35                  40                  45              


Ser Leu Cys Met Asn Cys Tyr Cys Asn Gly Met Thr Arg Leu Leu Leu 
    50                  55                  60                  


Thr Lys Ile Pro Phe Phe Arg Glu Ile Ile Val Ser Ser Phe Ser Cys 
65                  70                  75                  80  


Glu His Cys Gly Trp Asn Asn Thr Glu Ile Gln Ser Ala Gly Arg Ile 
                85                  90                  95      


Gln Asp Gln Gly Val Arg Tyr Thr Leu Ser Val Arg Ala Leu Glu Asp 
            100                 105                 110         


Met Asn Arg Glu Val Val Lys Thr Asp Ser Ala Ala Thr Arg Ile Pro 
        115                 120                 125             


Glu Leu Asp Phe Glu Ile Pro Ala Phe Ser Gln Lys Gly Ala Leu Thr 
    130                 135                 140                 


Thr Val Glu Gly Leu Ile Thr Arg Ala Ile Ser Gly Leu Glu Gln Asp 
145                 150                 155                 160 


Gln Pro Ala Arg Arg Ala Asn Lys Asp Ala Thr Ala Glu Arg Ile Asp 
                165                 170                 175     


Glu Phe Ile Val Lys Leu Lys Glu Leu Lys Gln Val Ala Ser Pro Phe 
            180                 185                 190         


Thr Leu Ile Ile Asp Asp Pro Ser Gly Asn Ser Phe Val Glu Asn Pro 
        195                 200                 205             


His Ala Pro Gln Lys Asp Asp Ala Leu Val Ile Thr His Tyr Asn Arg 
    210                 215                 220                 


Thr Arg Gln Gln Glu Glu Met Leu Gly Leu Gln Glu Glu Ala Pro Ala 
225                 230                 235                 240 


Glu Lys Pro Glu Glu Glu Asp Leu Arg Asn Glu Val Leu Gln Phe Ser 
                245                 250                 255     


Thr Asn Cys Pro Glu Cys Asn Ala Pro Ala Gln Thr Asn Met Lys Leu 
            260                 265                 270         


Val Gln Ile Pro His Phe Lys Glu Val Ile Ile Met Ala Thr Asn Cys 
        275                 280                 285             


Glu Asn Cys Gly His Arg Thr Asn Glu Val Lys Ser Gly Gly Ala Val 
    290                 295                 300                 


Glu Pro Leu Gly Thr Arg Ile Thr Leu His Ile Thr Asp Ala Ser Asp 
305                 310                 315                 320 


Met Thr Arg Asp Leu Leu Lys Ser Glu Thr Cys Ser Val Glu Ile Pro 
                325                 330                 335     


Glu Leu Glu Phe Glu Leu Gly Met Ala Val Leu Gly Gly Lys Phe Thr 
            340                 345                 350         


Thr Leu Glu Gly Leu Leu Lys Asp Ile Arg Glu Leu Val Thr Lys Asn 
        355                 360                 365             


Pro Phe Thr Leu Gly Asp Ser Ser Asn Pro Gly Gln Thr Glu Arg Leu 
    370                 375                 380                 


Gln Glu Phe Ser Gln Lys Met Asp Gln Ile Ile Glu Gly Asn Met Lys 
385                 390                 395                 400 


Ala His Phe Ile Met Asp Asp Pro Ala Gly Asn Ser Tyr Leu Gln Asn 
                405                 410                 415     


Val Tyr Ala Pro Glu Asp Asp Pro Glu Met Lys Val Glu Arg Tyr Lys 
            420                 425                 430         


Arg Thr Phe Asp Gln Asn Glu Glu Leu Gly Leu Asn Asp Met Lys Thr 
        435                 440                 445             


Glu Gly Tyr Glu Ala Gly Leu Ala Pro Gln Arg 
    450                 455                 


<210> 4742
<211> 619
<212> PRT
<213> Homo sapiens

<400> 4742
Met Leu Leu Ala Ser Ala Val Val Val Trp Glu Trp Leu Asn Glu His 
1               5                   10                  15      


Gly Arg Trp Arg Pro Tyr Ser Pro Ala Val Ser His His Ile Glu Ala 
            20                  25                  30          


Val Val Arg Ala Gly Pro Arg Ala Gly Gly Ser Val Val Leu Gly Gln 
        35                  40                  45              


Val Asp Ser Arg Leu Ala Pro Tyr Ile Ile Asp Leu Gln Ser Met Asn 
    50                  55                  60                  


Gln Phe Arg Gln Asp Thr Gly Thr Leu Arg Pro Val Arg Arg Asn Tyr 
65                  70                  75                  80  


Tyr Asp Pro Ser Ser Ala Pro Gly Lys Gly Val Val Trp Glu Trp Glu 
                85                  90                  95      


Asn Asp Asn Gly Ser Trp Thr Pro Tyr Asp Met Glu Val Gly Ile Thr 
            100                 105                 110         


Ile Gln His Ala Tyr Glu Lys Gln His Pro Trp Ile Asp Leu Thr Ser 
        115                 120                 125             


Ile Gly Phe Ser Tyr Val Ile Asp Phe Asn Thr Met Gly Gln Ile Asn 
    130                 135                 140                 


Arg Gln Thr Gln Arg Gln Arg Arg Val Arg Arg Arg Leu Asp Leu Ile 
145                 150                 155                 160 


Tyr Pro Met Val Thr Gly Thr Leu Pro Lys Ala Gln Ser Trp Pro Val 
                165                 170                 175     


Ser Pro Gly Pro Ala Thr Ser Pro Pro Met Ser Pro Cys Ser Cys Pro 
            180                 185                 190         


Gln Cys Val Leu Val Met Ser Val Lys Ala Ala Val Val Asn Gly Ser 
        195                 200                 205             


Thr Gly Pro Leu Gln Leu Pro Val Thr Arg Lys Asn Met Pro Pro Pro 
    210                 215                 220                 


Gly Val Val Lys Leu Pro Pro Leu Pro Gly Ser Gly Ala Lys Pro Leu 
225                 230                 235                 240 


Asp Ser Thr Gly Thr Ile Arg Gly Pro Leu Lys Thr Ala Pro Ser Gln 
                245                 250                 255     


Val Ile Arg Arg Gln Ala Ser Ser Met Pro Thr Gly Thr Thr Met Gly 
            260                 265                 270         


Ser Pro Ala Ser Pro Pro Gly Pro Asn Ser Lys Thr Gly Arg Val Ala 
        275                 280                 285             


Leu Ala Thr Leu Asn Arg Thr Asn Leu Gln Arg Leu Ala Ile Ala Gln 
    290                 295                 300                 


Ser Arg Val Leu Ile Ala Ser Gly Val Pro Thr Val Pro Val Lys Asn 
305                 310                 315                 320 


Leu Asn Gly Ser Ser Pro Val Asn Pro Ala Leu Ala Gly Ile Thr Gly 
                325                 330                 335     


Ile Leu Met Ser Ala Ala Gly Leu Pro Val Cys Leu Thr Arg Pro Pro 
            340                 345                 350         


Lys Leu Val Leu His Pro Pro Pro Val Ser Lys Ser Glu Ile Lys Ser 
        355                 360                 365             


Ile Pro Gly Val Ser Asn Thr Ser Arg Lys Thr Thr Lys Lys Gln Ala 
    370                 375                 380                 


Lys Lys Gly Lys Thr Pro Glu Glu Val Leu Lys Lys Tyr Leu Gln Lys 
385                 390                 395                 400 


Val Arg His Pro Pro Asp Glu Asp Cys Thr Ile Cys Met Glu Arg Leu 
                405                 410                 415     


Thr Ala Pro Ser Gly Tyr Lys Gly Pro Gln Pro Thr Val Lys Pro Asp 
            420                 425                 430         


Leu Val Gly Lys Leu Ser Arg Cys Gly His Val Tyr His Ile Tyr Cys 
        435                 440                 445             


Leu Val Ala Met Tyr Asn Asn Gly Asn Lys Asp Gly Ser Leu Gln Cys 
    450                 455                 460                 


Pro Thr Cys Lys Thr Ile Tyr Gly Val Lys Thr Gly Thr Gln Pro Pro 
465                 470                 475                 480 


Gly Lys Met Glu Tyr His Leu Ile Pro His Ser Leu Pro Gly His Pro 
                485                 490                 495     


Asp Cys Lys Thr Ile Arg Ile Ile Tyr Ser Ile Pro Pro Gly Ile Gln 
            500                 505                 510         


Gly Pro Glu His Pro Asn Pro Gly Lys Ser Phe Ser Ala Arg Gly Phe 
        515                 520                 525             


Pro Arg His Cys Tyr Leu Pro Asp Ser Glu Lys Gly Arg Lys Val Leu 
    530                 535                 540                 


Lys Leu Leu Leu Val Ala Trp Asp Arg Arg Leu Ile Phe Ala Ile Gly 
545                 550                 555                 560 


Thr Ser Ser Thr Thr Gly Glu Ser Asp Thr Val Ile Trp Asn Glu Val 
                565                 570                 575     


His His Lys Thr Glu Phe Gly Ser Asn Leu Thr Gly His Gly Tyr Pro 
            580                 585                 590         


Asp Ala Asn Tyr Leu Asp Asn Val Leu Ala Glu Leu Ala Ala Gln Gly 
        595                 600                 605             


Ile Ser Glu Asp Ser Thr Ala Gln Glu Lys Asp 
    610                 615                 


<210> 4743
<211> 178
<212> PRT
<213> Homo sapiens

<400> 4743
Met Pro Ala Tyr His Ser Ser Leu Met Asp Pro Asp Thr Lys Leu Ile 
1               5                   10                  15      


Gly Asn Met Ala Leu Leu Pro Ile Arg Ser Gln Phe Lys Gly Pro Ala 
            20                  25                  30          


Pro Arg Glu Thr Lys Asp Thr Asp Ile Val Asp Glu Ala Ile Tyr Tyr 
        35                  40                  45              


Phe Lys Ala Asn Val Phe Phe Lys Asn Tyr Glu Ile Lys Asn Glu Ala 
    50                  55                  60                  


Asp Arg Thr Leu Ile Tyr Ile Thr Leu Tyr Ile Ser Glu Cys Leu Lys 
65                  70                  75                  80  


Lys Leu Gln Lys Cys Asn Ser Lys Ser Gln Gly Glu Lys Glu Met Tyr 
                85                  90                  95      


Thr Leu Gly Ile Thr Asn Phe Pro Ile Pro Gly Glu Pro Gly Phe Pro 
            100                 105                 110         


Leu Asn Ala Ile Tyr Ala Lys Pro Ala Asn Lys Gln Glu Asp Glu Val 
        115                 120                 125             


Met Arg Ala Tyr Leu Gln Gln Leu Arg Gln Glu Thr Gly Leu Arg Leu 
    130                 135                 140                 


Cys Glu Lys Val Phe Asp Pro Gln Asn Asp Lys Pro Ser Lys Trp Trp 
145                 150                 155                 160 


Thr Cys Phe Val Lys Arg Gln Phe Met Asn Lys Ser Leu Ser Gly Pro 
                165                 170                 175     


Gly Gln 
        


<210> 4744
<211> 853
<212> PRT
<213> Homo sapiens

<400> 4744
Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met 
            20                  25                  30          


Asp Thr Ser Thr Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp 
        35                  40                  45              


Leu Glu Lys Ser Thr Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly 
    50                  55                  60                  


Glu Ser Phe Gly Gly Glu Thr Ser Asn Ser Gly Asp Pro His Lys Gly 
65                  70                  75                  80  


Phe Ser Val Asp Tyr Tyr Asn Thr Thr Thr Lys Gly Thr Pro Glu Arg 
                85                  90                  95      


Leu His Phe Glu Met Thr His Lys Glu Ile Pro Cys Gln Gly Pro Arg 
            100                 105                 110         


Ala Gln Leu Gly Asn Gly Ser Ser Val Asp Glu Val Ser Phe Tyr Ala 
        115                 120                 125             


Asn Arg Leu Thr Asn Leu Val Ile Ala Met Ala Arg Lys Glu Ile Asn 
    130                 135                 140                 


Glu Lys Ile Asp Gly Ser Glu Asn Lys Cys Val Tyr Gln Ser Leu Tyr 
145                 150                 155                 160 


Met Gly Asn Glu Pro Thr Pro Thr Lys Ser Leu Ser Lys Ile Ala Ser 
                165                 170                 175     


Glu Leu Val Asn Glu Thr Val Ser Ala Cys Ser Arg Asn Ala Ala Pro 
            180                 185                 190         


Asp Lys Ala Pro Gly Ser Gly Asp Arg Val Ser Gly Ser Ser Gln Ser 
        195                 200                 205             


Pro Pro Asn Leu Lys Tyr Lys Ser Thr Leu Lys Ile Lys Glu Ser Thr 
    210                 215                 220                 


Lys Glu Arg Gln Gly Pro Asp Asp Lys Pro Pro Ser Lys Lys Ser Phe 
225                 230                 235                 240 


Phe Tyr Lys Glu Val Phe Glu Ser Arg Asn Gly Asp Tyr Ala Arg Glu 
                245                 250                 255     


Gly Gly Arg Phe Phe Pro Arg Glu Arg Lys Arg Phe Arg Gly Gln Glu 
            260                 265                 270         


Arg Pro Asp Asp Phe Thr Ala Ser Val Ser Glu Gly Ile Met Thr Tyr 
        275                 280                 285             


Ala Asn Ser Val Val Ser Asp Met Met Val Ser Ile Met Lys Thr Leu 
    290                 295                 300                 


Lys Ile Gln Val Lys Asp Thr Thr Ile Ala Thr Ile Leu Leu Lys Lys 
305                 310                 315                 320 


Val Leu Leu Lys His Ala Lys Glu Val Val Ser Asp Leu Ile Asp Ser 
                325                 330                 335     


Phe Leu Arg Asn Leu His Ser Val Thr Gly Thr Leu Met Thr Asp Thr 
            340                 345                 350         


Gln Phe Val Ser Ala Val Lys Arg Thr Val Phe Ser His Gly Ser Gln 
        355                 360                 365             


Lys Ala Thr Asp Ile Met Asp Ala Met Leu Arg Lys Leu Tyr Asn Val 
    370                 375                 380                 


Met Phe Ala Lys Lys Val Pro Glu His Val Arg Lys Ala Gln Asp Lys 
385                 390                 395                 400 


Ala Glu Ser Tyr Ser Leu Ile Ser Met Lys Gly Met Gly Asp Pro Lys 
                405                 410                 415     


Asn Arg Asn Val Asn Phe Ala Met Lys Ser Glu Thr Lys Leu Arg Glu 
            420                 425                 430         


Lys Met Tyr Ser Glu Pro Lys Ser Glu Glu Glu Thr Cys Ala Lys Thr 
        435                 440                 445             


Leu Gly Glu His Ile Ile Lys Glu Gly Leu Thr Leu Trp His Lys Thr 
    450                 455                 460                 


Gln Gln Lys Glu Cys Lys Ser Leu Gly Phe Gln His Ala Ala Phe Glu 
465                 470                 475                 480 


Ala Pro Asn Thr Gln Arg Lys Pro Ala Ser Asp Ile Ser Phe Glu Tyr 
                485                 490                 495     


Pro Glu Asp Ile Gly Asn Leu Ser Leu Pro Pro Tyr Pro Pro Glu Lys 
            500                 505                 510         


Pro Glu Asn Phe Met Tyr Asp Ser Asp Ser Trp Ala Glu Asp Leu Ile 
        515                 520                 525             


Val Ser Ala Leu Leu Leu Ile Gln Tyr His Leu Ala Gln Gly Gly Arg 
    530                 535                 540                 


Arg Asp Ala Arg Ser Phe Val Glu Ala Ala Gly Thr Thr Asn Phe Pro 
545                 550                 555                 560 


Ala Asn Glu Pro Pro Val Ala Pro Asp Glu Ser Cys Leu Lys Ser Ala 
                565                 570                 575     


Pro Ile Val Gly Asp Gln Glu Gln Ala Glu Lys Lys Asp Leu Arg Ser 
            580                 585                 590         


Val Phe Phe Asn Phe Ile Arg Asn Leu Leu Ser Glu Thr Ile Phe Lys 
        595                 600                 605             


Arg Asp Gln Ser Pro Glu Pro Lys Val Pro Glu Gln Pro Val Lys Glu 
    610                 615                 620                 


Asp Arg Lys Leu Cys Glu Arg Pro Leu Ala Ser Ser Pro Pro Arg Leu 
625                 630                 635                 640 


Tyr Glu Asp Asp Glu Thr Pro Gly Ala Leu Ser Gly Leu Thr Lys Met 
                645                 650                 655     


Ala Val Ser Gln Ile Asp Gly His Met Ser Gly Gln Met Val Glu His 
            660                 665                 670         


Leu Met Asn Ser Val Met Lys Leu Cys Val Ile Ile Ala Lys Ser Cys 
        675                 680                 685             


Asp Ala Ser Leu Ala Glu Leu Gly Asp Asp Lys Ser Gly Asp Ala Ser 
    690                 695                 700                 


Arg Leu Thr Ser Ala Phe Pro Asp Ser Leu Tyr Glu Cys Leu Pro Ala 
705                 710                 715                 720 


Lys Gly Thr Gly Ser Ala Glu Ala Val Leu Gln Asn Ala Tyr Gln Ala 
                725                 730                 735     


Ile His Asn Glu Met Arg Gly Thr Ser Gly Gln Pro Pro Glu Gly Cys 
            740                 745                 750         


Ala Ala Pro Thr Val Ile Val Ser Asn His Asn Leu Thr Asp Thr Val 
        755                 760                 765             


Gln Asn Lys Gln Leu Gln Ala Val Leu Gln Trp Val Ala Ala Ser Glu 
    770                 775                 780                 


Leu Asn Val Pro Ile Leu Tyr Phe Ala Gly Asp Asp Glu Gly Ile Gln 
785                 790                 795                 800 


Glu Lys Leu Leu Gln Leu Ser Ala Ala Ala Val Asp Lys Gly Cys Ser 
                805                 810                 815     


Val Gly Glu Val Leu Gln Ser Val Leu Arg Tyr Glu Lys Glu Arg Gln 
            820                 825                 830         


Leu Asn Glu Ala Val Gly Asn Val Thr Pro Leu Gln Leu Leu Asp Trp 
        835                 840                 845             


Leu Met Val Asn Leu 
    850             


<210> 4745
<211> 665
<212> PRT
<213> Homo sapiens

<400> 4745
Met Ala His Glu Met Ile Gly Thr Gln Ile Val Thr Glu Arg Leu Val 
1               5                   10                  15      


Ala Leu Leu Glu Ser Gly Thr Glu Lys Val Leu Leu Ile Asp Ser Arg 
            20                  25                  30          


Pro Phe Val Glu Tyr Asn Thr Ser His Ile Leu Glu Ala Ile Asn Ile 
        35                  40                  45              


Asn Cys Ser Lys Leu Met Lys Arg Arg Leu Gln Gln Asp Lys Val Leu 
    50                  55                  60                  


Ile Thr Glu Leu Ile Gln His Ser Ala Lys His Lys Val Asp Ile Asp 
65                  70                  75                  80  


Cys Ser Gln Lys Val Val Val Tyr Asp Gln Ser Ser Gln Asp Val Ala 
                85                  90                  95      


Ser Leu Ser Ser Asp Cys Phe Leu Thr Val Leu Leu Gly Lys Leu Glu 
            100                 105                 110         


Lys Ser Phe Asn Ser Val His Leu Leu Ala Gly Gly Phe Ala Glu Phe 
        115                 120                 125             


Ser Arg Cys Phe Pro Gly Leu Cys Glu Gly Lys Ser Thr Leu Val Pro 
    130                 135                 140                 


Thr Cys Ile Ser Gln Pro Cys Leu Pro Val Ala Asn Ile Gly Pro Thr 
145                 150                 155                 160 


Arg Ile Leu Pro Asn Leu Tyr Leu Gly Cys Gln Arg Asp Val Leu Asn 
                165                 170                 175     


Lys Glu Leu Met Gln Gln Asn Gly Ile Gly Tyr Val Leu Asn Ala Ser 
            180                 185                 190         


Asn Thr Cys Pro Lys Pro Asp Phe Ile Pro Glu Ser His Phe Leu Arg 
        195                 200                 205             


Val Pro Val Asn Asp Ser Phe Cys Glu Lys Ile Leu Pro Trp Leu Asp 
    210                 215                 220                 


Lys Ser Val Asp Phe Ile Glu Lys Ala Lys Ala Ser Asn Gly Cys Val 
225                 230                 235                 240 


Leu Val His Cys Leu Ala Gly Ile Ser Arg Ser Ala Thr Ile Ala Ile 
                245                 250                 255     


Ala Tyr Ile Met Lys Arg Met Asp Met Ser Leu Asp Glu Ala Tyr Arg 
            260                 265                 270         


Phe Val Lys Glu Lys Arg Pro Thr Ile Ser Pro Asn Phe Asn Phe Leu 
        275                 280                 285             


Gly Gln Leu Leu Asp Tyr Glu Lys Lys Ile Lys Asn Gln Thr Gly Ala 
    290                 295                 300                 


Ser Gly Pro Lys Ser Lys Leu Lys Leu Leu His Leu Glu Lys Pro Asn 
305                 310                 315                 320 


Glu Pro Val Pro Ala Val Ser Glu Gly Gly Gln Lys Ser Glu Thr Pro 
                325                 330                 335     


Leu Ser Pro Pro Cys Ala Asp Ser Ala Thr Ser Glu Ala Ala Gly Gln 
            340                 345                 350         


Arg Pro Val His Pro Ala Ser Val Pro Ser Val Pro Ser Val Gln Pro 
        355                 360                 365             


Ser Leu Leu Glu Asp Ser Pro Leu Val Gln Ala Leu Ser Gly Leu His 
    370                 375                 380                 


Leu Ser Ala Asp Arg Leu Glu Asp Ser Asn Lys Leu Lys Arg Ser Phe 
385                 390                 395                 400 


Ser Leu Asp Ile Lys Ser Val Ser Tyr Ser Ala Ser Met Ala Ala Ser 
                405                 410                 415     


Leu His Gly Phe Ser Ser Ser Glu Asp Ala Leu Glu Tyr Tyr Lys Pro 
            420                 425                 430         


Ser Thr Thr Leu Asp Gly Thr Asn Lys Leu Cys Gln Phe Ser Pro Val 
        435                 440                 445             


Gln Glu Leu Ser Glu Gln Thr Pro Glu Thr Ser Pro Asp Lys Glu Glu 
    450                 455                 460                 


Ala Ser Ile Pro Lys Lys Leu Gln Thr Ala Arg Pro Ser Asp Ser Gln 
465                 470                 475                 480 


Ser Lys Arg Leu His Ser Val Arg Thr Ser Ser Ser Gly Thr Ala Gln 
                485                 490                 495     


Arg Ser Leu Leu Ser Pro Leu His Arg Ser Gly Ser Val Glu Asp Asn 
            500                 505                 510         


Tyr His Thr Ser Phe Leu Phe Gly Leu Ser Thr Ser Gln Gln His Leu 
        515                 520                 525             


Thr Lys Ser Ala Gly Leu Gly Leu Lys Gly Trp His Ser Asp Ile Leu 
    530                 535                 540                 


Ala Pro Gln Thr Ser Thr Pro Ser Leu Thr Ser Ser Trp Tyr Phe Ala 
545                 550                 555                 560 


Thr Glu Ser Ser His Phe Tyr Ser Ala Ser Ala Ile Tyr Gly Gly Ser 
                565                 570                 575     


Ala Ser Tyr Ser Ala Tyr Ser Cys Ser Gln Leu Pro Thr Cys Gly Asp 
            580                 585                 590         


Gln Val Tyr Ser Val Arg Arg Arg Gln Lys Pro Ser Asp Arg Ala Asp 
        595                 600                 605             


Ser Arg Arg Ser Trp His Glu Glu Ser Pro Phe Glu Lys Gln Phe Lys 
    610                 615                 620                 


Arg Arg Ser Cys Gln Met Glu Phe Gly Glu Ser Ile Met Ser Glu Asn 
625                 630                 635                 640 


Arg Ser Arg Glu Glu Leu Gly Lys Val Gly Ser Gln Ser Ser Phe Ser 
                645                 650                 655     


Gly Ser Met Glu Ile Ile Glu Val Ser 
            660                 665 


<210> 4746
<211> 275
<212> PRT
<213> Homo sapiens

<400> 4746
Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210> 4747
<211> 253
<212> PRT
<213> Homo sapiens

<400> 4747
Met Ser Cys Thr Ile Glu Lys Ala Leu Ala Asp Ala Lys Ala Leu Val 
1               5                   10                  15      


Glu Arg Leu Arg Asp His Asp Asp Ala Ala Glu Ser Leu Ile Glu Gln 
            20                  25                  30          


Thr Thr Ala Leu Asn Lys Arg Val Glu Ala Met Lys Gln Tyr Gln Glu 
        35                  40                  45              


Glu Ile Gln Glu Leu Asn Glu Val Ala Arg His Arg Pro Arg Ser Thr 
    50                  55                  60                  


Leu Val Met Gly Ile Gln Gln Glu Asn Arg Gln Ile Arg Glu Leu Gln 
65                  70                  75                  80  


Gln Glu Asn Lys Glu Leu Arg Thr Ser Leu Glu Glu His Gln Ser Ala 
                85                  90                  95      


Leu Glu Leu Ile Met Ser Lys Tyr Arg Glu Gln Met Phe Arg Leu Leu 
            100                 105                 110         


Met Ala Ser Lys Lys Asp Asp Pro Gly Ile Ile Met Lys Leu Lys Glu 
        115                 120                 125             


Gln His Ser Lys Ile Asp Met Val His Arg Asn Lys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Asp Ala Ser Arg His Ile Leu Glu Ala Pro Gln His Gly Leu 
145                 150                 155                 160 


Glu Arg Arg His Leu Glu Ala Asn Gln Asn Glu Leu Gln Ala His Val 
                165                 170                 175     


Asp Gln Ile Thr Glu Met Ala Ala Val Met Arg Lys Ala Ile Glu Ile 
            180                 185                 190         


Asp Glu Gln Gln Gly Cys Lys Glu Gln Glu Arg Ile Phe Gln Leu Glu 
        195                 200                 205             


Gln Glu Asn Lys Gly Leu Arg Glu Ile Leu Gln Ile Thr Arg Glu Ser 
    210                 215                 220                 


Phe Leu Asn Leu Arg Lys Asp Asp Ala Ser Glu Ser Thr Ser Leu Ser 
225                 230                 235                 240 


Ala Leu Val Thr Asn Ser Asp Leu Ser Leu Arg Lys Ser 
                245                 250             


<210> 4748
<211> 140
<212> PRT
<213> Homo sapiens

<400> 4748
Met Thr Ser Met Thr Gln Ser Leu Arg Glu Val Ile Lys Ala Met Thr 
1               5                   10                  15      


Lys Ala Arg Asn Phe Glu Arg Val Leu Gly Lys Ile Thr Leu Val Ser 
            20                  25                  30          


Ala Ala Pro Gly Lys Val Ile Cys Glu Met Lys Val Glu Glu Glu His 
        35                  40                  45              


Thr Asn Ala Ile Gly Thr Leu His Gly Gly Leu Thr Ala Thr Leu Val 
    50                  55                  60                  


Asp Asn Ile Ser Thr Met Ala Leu Leu Cys Thr Glu Arg Gly Ala Pro 
65                  70                  75                  80  


Gly Val Ser Val Asp Met Asn Ile Thr Tyr Met Ser Pro Ala Lys Leu 
                85                  90                  95      


Gly Glu Asp Ile Val Ile Thr Ala His Val Leu Lys Gln Gly Lys Thr 
            100                 105                 110         


Leu Ala Phe Thr Ser Val Asp Leu Thr Asn Lys Ala Thr Gly Lys Leu 
        115                 120                 125             


Ile Ala Gln Gly Arg His Thr Lys His Leu Gly Asn 
    130                 135                 140 


<210> 4749
<211> 209
<212> PRT
<213> Homo sapiens

<400> 4749
Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 
65                  70                  75                  80  


Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 
                85                  90                  95      


Gln Tyr Trp Lys Glu Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu 
            100                 105                 110         


Ala Leu Lys Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp 
        115                 120                 125             


Asn Glu Ile Ala Arg Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val 
    130                 135                 140                 


Ala Glu His Val Gln Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly 
145                 150                 155                 160 


Glu Pro Leu Asp Asn Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser 
                165                 170                 175     


Glu Glu Glu Thr Val Glu Asp Ser Leu Val Glu Asp Ser Glu Ile Gly 
            180                 185                 190         


Thr Cys Ala Glu Gly Thr Val Ser Ser Ser Thr Asp Ala Lys Pro Cys 
        195                 200                 205             


Ile 
    


<210> 4750
<211> 174
<212> PRT
<213> Homo sapiens

<400> 4750
Met Ala Ala Ala Met Val Pro Gly Arg Ser Glu Ser Trp Glu Arg Gly 
1               5                   10                  15      


Glu Pro Gly Arg Pro Ala Leu Tyr Phe Cys Gly Ser Ile Arg Gly Gly 
            20                  25                  30          


Arg Glu Asp Arg Thr Leu Tyr Glu Arg Ile Val Ser Arg Leu Arg Arg 
        35                  40                  45              


Phe Gly Thr Val Leu Thr Glu His Val Ala Ala Ala Glu Leu Gly Ala 
    50                  55                  60                  


Arg Gly Glu Glu Ala Ala Gly Gly Asp Arg Leu Ile His Glu Gln Asp 
65                  70                  75                  80  


Leu Glu Trp Leu Gln Gln Ala Asp Val Val Val Ala Glu Val Thr Gln 
                85                  90                  95      


Pro Ser Leu Gly Val Gly Tyr Glu Leu Gly Arg Ala Val Ala Phe Asn 
            100                 105                 110         


Lys Arg Ile Leu Cys Leu Phe Arg Pro Gln Ser Gly Arg Val Leu Ser 
        115                 120                 125             


Ala Met Ile Arg Gly Ala Ala Asp Gly Ser Arg Phe Gln Val Trp Asp 
    130                 135                 140                 


Tyr Glu Glu Gly Glu Val Glu Ala Leu Leu Asp Arg Tyr Phe Glu Ala 
145                 150                 155                 160 


Asp Pro Pro Gly Gln Val Ala Ala Ser Pro Asp Pro Thr Thr 
                165                 170                 


<210> 4751
<211> 462
<212> PRT
<213> Homo sapiens

<400> 4751
Met Ser Ser Val Lys Arg Ser Leu Lys Gln Glu Ile Val Thr Gln Phe 
1               5                   10                  15      


His Cys Ser Ala Ala Glu Gly Asp Ile Ala Lys Leu Thr Gly Ile Leu 
            20                  25                  30          


Ser His Ser Pro Ser Leu Leu Asn Glu Thr Ser Glu Asn Gly Trp Thr 
        35                  40                  45              


Ala Leu Met Tyr Ala Ala Arg Asn Gly His Pro Glu Ile Val Gln Phe 
    50                  55                  60                  


Leu Leu Glu Lys Gly Cys Asp Arg Ser Ile Val Asn Lys Ser Arg Gln 
65                  70                  75                  80  


Thr Ala Leu Asp Ile Ala Val Phe Trp Gly Tyr Lys His Ile Ala Asn 
                85                  90                  95      


Leu Leu Ala Thr Ala Lys Gly Gly Lys Lys Pro Trp Phe Leu Thr Asn 
            100                 105                 110         


Glu Val Glu Glu Cys Glu Asn Tyr Phe Ser Lys Thr Leu Leu Asp Arg 
        115                 120                 125             


Lys Ser Glu Lys Arg Asn Asn Ser Asp Trp Leu Leu Ala Lys Glu Ser 
    130                 135                 140                 


His Pro Ala Thr Val Phe Ile Leu Phe Ser Asp Leu Asn Pro Leu Val 
145                 150                 155                 160 


Thr Leu Gly Gly Asn Lys Glu Ser Phe Gln Gln Pro Glu Val Arg Leu 
                165                 170                 175     


Cys Gln Leu Asn Tyr Thr Asp Ile Lys Asp Tyr Leu Ala Gln Pro Glu 
            180                 185                 190         


Lys Ile Thr Leu Ile Phe Leu Gly Val Glu Leu Glu Ile Lys Asp Lys 
        195                 200                 205             


Leu Leu Asn Tyr Ala Gly Glu Val Pro Arg Glu Glu Glu Asp Gly Leu 
    210                 215                 220                 


Val Ala Trp Phe Ala Leu Gly Ile Asp Pro Ile Ala Ala Glu Glu Phe 
225                 230                 235                 240 


Lys Gln Arg His Glu Asn Cys Tyr Phe Leu His Pro Pro Met Pro Ala 
                245                 250                 255     


Leu Leu Gln Leu Lys Glu Lys Glu Ala Gly Val Val Ala Gln Ala Arg 
            260                 265                 270         


Ser Val Leu Ala Trp His Ser Arg Tyr Lys Phe Cys Pro Thr Cys Gly 
        275                 280                 285             


Asn Ala Thr Lys Ile Glu Glu Gly Gly Tyr Lys Arg Leu Cys Leu Lys 
    290                 295                 300                 


Glu Asp Cys Pro Ser Leu Asn Gly Val His Asn Thr Ser Tyr Pro Arg 
305                 310                 315                 320 


Val Asp Pro Val Val Ile Met Gln Val Ile His Pro Asp Gly Thr Lys 
                325                 330                 335     


Cys Leu Leu Gly Arg Gln Lys Arg Phe Pro Pro Gly Met Phe Thr Cys 
            340                 345                 350         


Leu Ala Gly Phe Ile Glu Pro Gly Glu Thr Ile Glu Asp Ala Val Arg 
        355                 360                 365             


Arg Glu Val Glu Glu Glu Ser Gly Val Lys Val Gly His Val Gln Tyr 
    370                 375                 380                 


Val Ala Cys Gln Pro Trp Pro Met Pro Ser Ser Leu Met Ile Gly Cys 
385                 390                 395                 400 


Leu Ala Leu Ala Val Ser Thr Glu Ile Lys Val Asp Lys Asn Glu Ile 
                405                 410                 415     


Glu Asp Ala Arg Trp Phe Thr Arg Glu Gln Val Leu Asp Val Leu Thr 
            420                 425                 430         


Lys Gly Lys Gln Gln Ala Phe Phe Val Pro Pro Ser Arg Ala Ile Ala 
        435                 440                 445             


His Gln Leu Ile Lys His Trp Ile Arg Ile Asn Pro Asn Leu 
    450                 455                 460         


<210> 4752
<211> 215
<212> PRT
<213> Homo sapiens

<400> 4752
Met Asn Leu Val Gly Ser Tyr Ala His His His His His His His Pro 
1               5                   10                  15      


His Pro Ala His Pro Met Leu His Glu Pro Phe Leu Phe Gly Pro Ala 
            20                  25                  30          


Ser Arg Cys His Gln Glu Arg Pro Tyr Phe Gln Ser Trp Leu Leu Ser 
        35                  40                  45              


Pro Ala Asp Ala Ala Pro Asp Phe Pro Ala Gly Gly Pro Pro Pro Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Thr Ala Tyr Gly Pro Asp Ala Arg Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Gly Arg Leu Glu Ala Leu Gly Gly Arg Leu Gly Arg Arg Lys 
                85                  90                  95      


Gly Ser Gly Pro Lys Lys Glu Arg Arg Arg Thr Glu Ser Ile Asn Ser 
            100                 105                 110         


Ala Phe Ala Glu Leu Arg Glu Cys Ile Pro Asn Val Pro Ala Asp Thr 
        115                 120                 125             


Lys Leu Ser Lys Ile Lys Thr Leu Arg Leu Ala Thr Ser Tyr Ile Ala 
    130                 135                 140                 


Tyr Leu Met Asp Val Leu Ala Lys Asp Ala Gln Ser Gly Asp Pro Glu 
145                 150                 155                 160 


Ala Phe Lys Ala Glu Leu Lys Lys Ala Asp Gly Gly Arg Glu Ser Lys 
                165                 170                 175     


Arg Lys Arg Glu Leu Gln Gln His Glu Gly Phe Pro Pro Ala Leu Gly 
            180                 185                 190         


Pro Val Glu Lys Arg Ile Lys Gly Arg Thr Gly Trp Pro Gln Gln Val 
        195                 200                 205             


Trp Ala Leu Glu Leu Asn Gln 
    210                 215 


<210> 4753
<211> 298
<212> PRT
<213> Homo sapiens

<400> 4753
Met Trp Gly Ala Cys Lys Val Lys Val His Asp Ser Leu Ala Thr Ile 
1               5                   10                  15      


Ser Ile Thr Leu Arg Arg Tyr Leu Arg Leu Gly Ala Thr Met Ala Lys 
            20                  25                  30          


Ser Lys Phe Glu Tyr Val Arg Asp Phe Glu Ala Asp Asp Thr Cys Leu 
        35                  40                  45              


Ala His Cys Trp Val Val Val Arg Leu Asp Gly Arg Asn Phe His Arg 
    50                  55                  60                  


Phe Ala Glu Lys His Asn Phe Ala Lys Pro Asn Asp Ser Arg Ala Leu 
65                  70                  75                  80  


Gln Leu Met Thr Lys Cys Ala Gln Thr Val Met Glu Glu Leu Glu Asp 
                85                  90                  95      


Ile Val Ile Ala Tyr Gly Gln Ser Asp Glu Tyr Ser Phe Val Phe Lys 
            100                 105                 110         


Arg Lys Thr Asn Trp Phe Lys Arg Arg Ala Ser Lys Phe Met Thr His 
        115                 120                 125             


Val Ala Ser Gln Phe Ala Ser Ser Tyr Val Phe Tyr Trp Arg Asp Tyr 
    130                 135                 140                 


Phe Glu Asp Gln Pro Leu Leu Tyr Pro Pro Gly Phe Asp Gly Arg Val 
145                 150                 155                 160 


Val Val Tyr Pro Ser Asn Gln Thr Leu Lys Asp Tyr Leu Ser Trp Arg 
                165                 170                 175     


Gln Ala Asp Cys His Ile Asn Asn Leu Tyr Asn Thr Val Phe Trp Ala 
            180                 185                 190         


Leu Ile Gln Gln Ser Gly Leu Thr Pro Val Gln Ala Gln Gly Arg Leu 
        195                 200                 205             


Gln Gly Thr Leu Ala Ala Asp Lys Asn Glu Ile Leu Phe Ser Glu Phe 
    210                 215                 220                 


Asn Ile Asn Tyr Asn Asn Glu Leu Pro Met Tyr Arg Lys Gly Thr Val 
225                 230                 235                 240 


Leu Ile Trp Gln Lys Val Asp Glu Val Met Thr Lys Glu Ile Lys Leu 
                245                 250                 255     


Pro Thr Glu Met Glu Gly Lys Lys Met Ala Val Thr Arg Thr Arg Thr 
            260                 265                 270         


Lys Pro Val Pro Leu His Cys Asp Ile Ile Gly Asp Ala Phe Trp Lys 
        275                 280                 285             


Glu His Pro Glu Ile Leu Asp Glu Asp Ser 
    290                 295             


<210> 4754
<211> 574
<212> PRT
<213> Homo sapiens

<400> 4754
Met Ala Thr Leu Val Val Asn Lys Leu Gly Ala Gly Val Asp Ser Gly 
1               5                   10                  15      


Arg Gln Gly Ser Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly 
            20                  25                  30          


Val Cys Glu Asp Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu 
        35                  40                  45              


Leu Leu Cys Gly His Thr Val Cys His Asp Cys Leu Thr Arg Leu Pro 
    50                  55                  60                  


Leu His Gly Arg Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp 
65                  70                  75                  80  


Leu Gly Asp Ser Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu 
                85                  90                  95      


Glu Leu Leu Glu Arg Leu Gln Asn Gly Pro Ile Gly Gln Tyr Gly Ala 
            100                 105                 110         


Ala Glu Glu Ser Ile Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp 
        115                 120                 125             


Glu Asp Glu Ala His Leu Ala Ser Val Tyr Cys Thr Val Cys Ala Thr 
    130                 135                 140                 


His Leu Cys Ser Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu 
145                 150                 155                 160 


Ala Lys His Arg Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr 
                165                 170                 175     


Met Cys Ser Gln His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu 
            180                 185                 190         


Glu Gly Cys Gln Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr 
        195                 200                 205             


Gly Lys His Gln Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn 
    210                 215                 220                 


Gln Ile Arg Ala Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe 
225                 230                 235                 240 


Thr Glu Glu Ile Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln 
                245                 250                 255     


His Ile Glu Gly Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala 
            260                 265                 270         


His Thr Glu His Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Ile 
        275                 280                 285             


Arg Ala Tyr Phe Tyr Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu 
    290                 295                 300                 


Met Ala Leu Ser Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp 
305                 310                 315                 320 


Leu Arg Gln Gln Gln Glu Asp Met Thr Ile Leu Leu Ser Glu Val Ser 
                325                 330                 335     


Ala Ala Cys Leu His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg 
            340                 345                 350         


Val Val Leu Ala Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln 
        355                 360                 365             


Lys Gln Gln Gln Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp 
    370                 375                 380                 


Ala Ser Ile Pro Val Thr Phe Thr Lys Asp Asn Arg Val His Ile Gly 
385                 390                 395                 400 


Pro Lys Met Glu Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly 
                405                 410                 415     


Lys Thr Thr Ile Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro 
            420                 425                 430         


Ile Pro Thr Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu 
        435                 440                 445             


Lys Phe Thr Ile Trp Asp Val Gly Gly Lys His Lys Leu Arg Pro Leu 
    450                 455                 460                 


Trp Lys His Tyr Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp 
465                 470                 475                 480 


Ser Ser His Arg Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys 
                485                 490                 495     


Leu Leu Thr Glu Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala 
            500                 505                 510         


Asn Lys Gln Asp Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu 
        515                 520                 525             


Leu Leu Ser Leu His Lys Leu Cys Cys Gly Arg Ser Trp Tyr Ile Gln 
    530                 535                 540                 


Gly Cys Asp Ala Arg Ser Gly Met Gly Leu Tyr Glu Gly Leu Asp Trp 
545                 550                 555                 560 


Leu Ser Arg Gln Leu Val Ala Ala Gly Val Leu Asp Val Ala 
                565                 570                 


<210> 4755
<211> 440
<212> PRT
<213> Homo sapiens

<400> 4755
Met Gly Asp Leu Glu Leu Leu Leu Pro Gly Glu Ala Glu Val Leu Val 
1               5                   10                  15      


Arg Gly Leu Arg Ser Phe Pro Leu Arg Glu Met Gly Ser Glu Gly Trp 
            20                  25                  30          


Asn Gln Gln His Glu Asn Leu Glu Lys Leu Asn Met Gln Ala Ile Leu 
        35                  40                  45              


Asp Ala Thr Val Ser Gln Gly Glu Pro Ile Gln Glu Leu Leu Val Thr 
    50                  55                  60                  


His Gly Lys Val Pro Thr Leu Val Glu Glu Leu Ile Ala Val Glu Met 
65                  70                  75                  80  


Trp Lys Gln Lys Val Phe Pro Val Phe Cys Arg Val Glu Asp Phe Lys 
                85                  90                  95      


Pro Gln Asn Thr Phe Pro Ile Tyr Met Val Val His His Glu Ala Ser 
            100                 105                 110         


Ile Ile Asn Leu Leu Glu Thr Val Phe Phe His Lys Glu Val Cys Glu 
        115                 120                 125             


Ser Ala Glu Asp Thr Val Leu Asp Leu Val Asp Tyr Cys His Arg Lys 
    130                 135                 140                 


Leu Thr Leu Leu Val Ala Gln Ser Gly Cys Gly Gly Pro Pro Glu Gly 
145                 150                 155                 160 


Glu Gly Ser Gln Asp Ser Asn Pro Met Gln Glu Leu Gln Lys Gln Ala 
                165                 170                 175     


Glu Leu Met Glu Phe Glu Ile Ala Leu Lys Ala Leu Ser Val Leu Arg 
            180                 185                 190         


Tyr Ile Thr Asp Cys Val Asp Ser Leu Ser Leu Ser Thr Leu Ser Arg 
        195                 200                 205             


Met Leu Ser Thr His Asn Leu Pro Cys Leu Leu Val Glu Leu Leu Glu 
    210                 215                 220                 


His Ser Pro Trp Ser Arg Arg Glu Gly Gly Lys Leu Gln Gln Phe Glu 
225                 230                 235                 240 


Gly Ser Arg Trp His Thr Val Ala Pro Ser Glu Gln Gln Lys Leu Ser 
                245                 250                 255     


Lys Leu Asp Gly Gln Val Trp Ile Ala Leu Tyr Asn Leu Leu Leu Ser 
            260                 265                 270         


Pro Glu Ala Gln Ala Arg Tyr Cys Leu Thr Ser Phe Ala Lys Gly Arg 
        275                 280                 285             


Leu Leu Lys Leu Arg Ala Phe Leu Thr Asp Thr Leu Leu Asp Gln Leu 
    290                 295                 300                 


Pro Asn Leu Ala His Leu Gln Ser Phe Leu Ala His Leu Thr Leu Thr 
305                 310                 315                 320 


Glu Thr Gln Pro Pro Lys Lys Asp Leu Val Leu Glu Gln Ile Pro Glu 
                325                 330                 335     


Ile Trp Glu Arg Leu Glu Arg Glu Asn Arg Gly Lys Trp Gln Ala Ile 
            340                 345                 350         


Ala Lys His Gln Leu Gln His Val Phe Ser Pro Ser Glu Gln Asp Leu 
        355                 360                 365             


Arg Leu Gln Ala Arg Arg Trp Ala Glu Thr Tyr Arg Leu Asp Val Leu 
    370                 375                 380                 


Glu Ala Val Ala Pro Glu Arg Pro Arg Cys Ala Tyr Cys Ser Ala Glu 
385                 390                 395                 400 


Ala Ser Lys Arg Cys Ser Arg Cys Gln Asn Glu Trp Tyr Cys Cys Arg 
                405                 410                 415     


Glu Cys Gln Val Lys His Trp Glu Lys His Gly Lys Thr Cys Val Leu 
            420                 425                 430         


Ala Ala Gln Gly Asp Arg Ala Lys 
        435                 440 


<210> 4756
<211> 338
<212> PRT
<213> Homo sapiens

<400> 4756
Met Glu Leu Trp Gly Arg Met Leu Trp Ala Leu Leu Ser Gly Pro Gly 
1               5                   10                  15      


Arg Arg Gly Ser Thr Arg Gly Trp Ala Phe Ser Ser Trp Gln Pro Gln 
            20                  25                  30          


Pro Pro Leu Ala Gly Leu Ser Ser Ala Ile Glu Leu Val Ser His Trp 
        35                  40                  45              


Thr Gly Val Phe Glu Lys Arg Gly Ile Pro Glu Ala Arg Glu Ser Ser 
    50                  55                  60                  


Glu Tyr Ile Val Ala His Val Leu Gly Ala Lys Thr Phe Gln Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Leu Trp Thr Gln Pro Leu Thr Ser Gln Gln Leu Gln Cys 
                85                  90                  95      


Ile Arg Glu Leu Ser Ser Arg Arg Leu Gln Arg Met Pro Val Gln Tyr 
            100                 105                 110         


Ile Leu Gly Glu Trp Asp Phe Gln Gly Leu Ser Leu Arg Met Val Pro 
        115                 120                 125             


Pro Val Phe Ile Pro Arg Pro Glu Thr Glu Glu Leu Val Glu Trp Val 
    130                 135                 140                 


Leu Glu Glu Val Ala Gln Arg Ser His Ala Val Gly Ser Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Ile Leu Glu Val Gly Cys Gly Ser Gly Ala Ile Ser Leu Ser 
                165                 170                 175     


Leu Leu Ser Gln Leu Pro Gln Ser Arg Val Ile Ala Val Asp Lys Arg 
            180                 185                 190         


Glu Ala Ala Ile Ser Leu Thr His Glu Asn Ala Gln Arg Leu Arg Leu 
        195                 200                 205             


Gln Asp Arg Ile Trp Ile Ile His Leu Asp Met Thr Ser Glu Arg Ser 
    210                 215                 220                 


Trp Thr His Leu Pro Trp Gly Pro Met Asp Leu Ile Val Ser Asn Pro 
225                 230                 235                 240 


Pro Tyr Val Phe His Gln Asp Met Glu Gln Leu Ala Pro Glu Ile Arg 
                245                 250                 255     


Ser Tyr Glu Asp Pro Ala Ala Leu Asp Gly Gly Glu Glu Gly Met Asp 
            260                 265                 270         


Ile Ile Thr His Ile Leu Ala Leu Ala Pro Arg Leu Leu Lys Asp Ser 
        275                 280                 285             


Gly Ser Ile Phe Leu Glu Val Asp Pro Arg His Pro Glu Leu Val Ser 
    290                 295                 300                 


Ser Trp Leu Gln Ser Arg Pro Asp Leu Tyr Leu Asn Leu Val Ala Val 
305                 310                 315                 320 


Arg Arg Asp Phe Cys Gly Arg Pro Arg Phe Leu His Ile Arg Arg Ser 
                325                 330                 335     


Gly Pro 
        


<210> 4757
<211> 410
<212> PRT
<213> Homo sapiens

<400> 4757
Met Ala Ala Glu Ile His Ser Arg Pro Gln Ser Ser Arg Pro Val Leu 
1               5                   10                  15      


Leu Ser Lys Ile Glu Gly His Gln Asp Ala Val Thr Ala Ala Leu Leu 
            20                  25                  30          


Ile Pro Lys Glu Asp Gly Val Ile Thr Ala Ser Glu Asp Arg Thr Ile 
        35                  40                  45              


Arg Val Trp Leu Lys Arg Asp Ser Gly Gln Tyr Trp Pro Ser Ile Tyr 
    50                  55                  60                  


His Thr Met Ala Ser Pro Cys Ser Ala Met Ala Tyr His His Asp Ser 
65                  70                  75                  80  


Arg Arg Ile Phe Val Gly Gln Asp Asn Gly Ala Val Met Glu Phe His 
                85                  90                  95      


Val Ser Glu Asp Phe Asn Lys Met Asn Phe Ile Lys Thr Tyr Pro Ala 
            100                 105                 110         


His Gln Asn Arg Val Ser Ala Ile Ile Phe Ser Leu Ala Thr Glu Trp 
        115                 120                 125             


Val Ile Ser Thr Gly His Asp Lys Cys Val Ser Trp Met Cys Thr Arg 
    130                 135                 140                 


Ser Gly Asn Met Leu Gly Arg His Phe Phe Thr Ser Trp Ala Ser Cys 
145                 150                 155                 160 


Leu Gln Tyr Asp Phe Asp Thr Gln Tyr Ala Phe Val Gly Asp Tyr Ser 
                165                 170                 175     


Gly Gln Ile Thr Leu Leu Lys Leu Glu Gln Asn Thr Cys Ser Val Ile 
            180                 185                 190         


Thr Thr Leu Lys Gly His Glu Gly Ser Val Ala Cys Leu Trp Trp Asp 
        195                 200                 205             


Pro Ile Gln Arg Leu Leu Phe Ser Gly Ala Ser Asp Asn Ser Ile Ile 
    210                 215                 220                 


Met Trp Asp Ile Gly Gly Arg Lys Gly Arg Thr Leu Leu Leu Gln Gly 
225                 230                 235                 240 


His His Asp Lys Val Gln Ser Leu Cys Tyr Leu Gln Leu Thr Arg Gln 
                245                 250                 255     


Leu Val Ser Cys Ser Ser Asp Gly Gly Ile Ala Val Trp Asn Met Asp 
            260                 265                 270         


Val Ser Arg Glu Glu Ala Pro Gln Trp Leu Glu Ser Asp Ser Cys Gln 
        275                 280                 285             


Lys Cys Glu Gln Pro Phe Phe Trp Asn Ile Lys Gln Met Trp Asp Thr 
    290                 295                 300                 


Lys Thr Leu Gly Leu Arg Gln His His Cys Arg Lys Cys Gly Gln Ala 
305                 310                 315                 320 


Val Cys Gly Lys Cys Ser Ser Lys Arg Ser Ser Tyr Pro Val Met Gly 
                325                 330                 335     


Phe Glu Phe Gln Val Arg Val Cys Asp Ser Cys Tyr Asp Ser Ile Lys 
            340                 345                 350         


Asp Glu Asp Arg Thr Ser Leu Ala Thr Phe His Glu Gly Lys His Asn 
        355                 360                 365             


Ile Ser His Met Ser Met Asp Ile Ala Arg Gly Leu Met Val Thr Cys 
    370                 375                 380                 


Gly Thr Asp Arg Ile Val Lys Ile Trp Asp Met Thr Pro Val Val Gly 
385                 390                 395                 400 


Cys Ser Leu Ala Thr Gly Phe Ser Pro His 
                405                 410 


<210> 4758
<211> 407
<212> PRT
<213> Homo sapiens

<400> 4758
Met Asn Asn Ser Gly Ala Asp Glu Ile Gly Lys Leu Phe Val Gly Gly 
1               5                   10                  15      


Leu Asp Trp Ser Thr Thr Gln Glu Thr Leu Arg Ser Tyr Phe Ser Gln 
            20                  25                  30          


Tyr Gly Glu Val Val Asp Cys Val Ile Met Lys Asp Lys Thr Thr Asn 
        35                  40                  45              


Gln Ser Arg Gly Phe Gly Phe Val Lys Phe Lys Asp Pro Asn Cys Val 
    50                  55                  60                  


Gly Thr Val Leu Ala Ser Arg Pro His Thr Leu Asp Gly Arg Asn Ile 
65                  70                  75                  80  


Asp Pro Lys Pro Cys Thr Pro Arg Gly Met Gln Pro Glu Arg Thr Arg 
                85                  90                  95      


Pro Lys Glu Gly Trp Gln Lys Gly Pro Arg Ser Asp Asn Ser Lys Ser 
            100                 105                 110         


Asn Lys Ile Phe Val Gly Gly Ile Pro His Asn Cys Gly Glu Thr Glu 
        115                 120                 125             


Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val Val Met 
    130                 135                 140                 


Ile Tyr Asp Ala Glu Lys Gln Arg Pro Arg Gly Phe Gly Phe Ile Thr 
145                 150                 155                 160 


Phe Glu Asp Glu Gln Ser Val Asp Gln Ala Val Asn Met His Phe His 
                165                 170                 175     


Asp Ile Met Gly Lys Lys Val Glu Val Lys Arg Ala Glu Pro Arg Asp 
            180                 185                 190         


Ser Lys Ser Gln Ala Pro Gly Gln Pro Gly Ala Ser Gln Trp Gly Ser 
        195                 200                 205             


Arg Val Val Pro Asn Ala Ala Asn Gly Trp Ala Gly Gln Pro Pro Pro 
    210                 215                 220                 


Thr Trp Gln Gln Gly Tyr Gly Pro Gln Gly Met Trp Val Pro Ala Gly 
225                 230                 235                 240 


Gln Ala Ile Gly Gly Tyr Gly Pro Pro Pro Ala Gly Arg Gly Ala Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Phe Thr Ser Tyr Ile Val Ser Thr Pro Pro Gly 
            260                 265                 270         


Gly Phe Pro Pro Pro Gln Gly Phe Pro Gln Gly Tyr Gly Ala Pro Pro 
        275                 280                 285             


Gln Phe Ser Phe Gly Tyr Gly Pro Pro Pro Pro Pro Pro Asp Gln Phe 
    290                 295                 300                 


Ala Pro Pro Gly Val Pro Pro Pro Pro Ala Thr Pro Gly Ala Ala Pro 
305                 310                 315                 320 


Leu Ala Phe Pro Pro Pro Pro Ser Gln Ala Ala Pro Asp Met Ser Lys 
                325                 330                 335     


Pro Pro Thr Ala Gln Pro Asp Phe Pro Tyr Gly Gln Tyr Ala Gly Tyr 
            340                 345                 350         


Gly Gln Asp Leu Ser Gly Phe Gly Gln Gly Phe Ser Asp Pro Ser Gln 
        355                 360                 365             


Gln Pro Pro Ser Tyr Gly Gly Pro Ser Val Pro Gly Ser Gly Gly Pro 
    370                 375                 380                 


Pro Ala Gly Gly Ser Gly Phe Gly Arg Gly Gln Asn His Asn Val Gln 
385                 390                 395                 400 


Gly Phe His Pro Tyr Arg Arg 
                405         


<210> 4759
<211> 44
<212> PRT
<213> Homo sapiens

<400> 4759
Met Ala Asp Lys Pro Asp Met Gly Glu Ile Ala Ser Phe Asp Lys Ala 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Thr Leu Pro Thr Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Arg Ser Glu Ile Ser 
        35                  40                  


<210> 4760
<211> 535
<212> PRT
<213> Homo sapiens

<400> 4760
Met Ser Glu Gly Glu Ser Gln Thr Val Leu Ser Ser Gly Ser Asp Pro 
1               5                   10                  15      


Lys Val Glu Ser Ser Ser Ser Ala Pro Gly Leu Thr Ser Val Ser Pro 
            20                  25                  30          


Pro Val Thr Ser Thr Thr Ser Ala Ala Ser Pro Glu Glu Glu Glu Glu 
        35                  40                  45              


Ser Glu Asp Glu Ser Glu Ile Leu Glu Glu Ser Pro Cys Gly Arg Trp 
    50                  55                  60                  


Gln Lys Arg Arg Glu Glu Val Asn Gln Arg Asn Val Pro Gly Ile Asp 
65                  70                  75                  80  


Ser Ala Tyr Leu Ala Met Asp Thr Glu Glu Gly Val Glu Val Val Trp 
                85                  90                  95      


Asn Glu Val Gln Phe Ser Glu Arg Lys Asn Tyr Lys Leu Gln Glu Glu 
            100                 105                 110         


Lys Val Arg Ala Val Phe Asp Asn Leu Ile Gln Leu Glu His Leu Asn 
        115                 120                 125             


Ile Val Lys Phe His Lys Tyr Trp Ala Asp Ile Lys Glu Asn Lys Ala 
    130                 135                 140                 


Arg Val Ile Phe Ile Thr Glu Tyr Met Ser Ser Gly Ser Leu Lys Gln 
145                 150                 155                 160 


Phe Leu Lys Lys Thr Lys Lys Asn His Lys Thr Met Asn Glu Lys Ala 
                165                 170                 175     


Trp Lys Arg Trp Cys Thr Gln Ile Leu Ser Ala Leu Ser Tyr Leu His 
            180                 185                 190         


Ser Cys Asp Pro Pro Ile Ile His Gly Asn Leu Thr Cys Asp Thr Ile 
        195                 200                 205             


Phe Ile Gln His Asn Gly Leu Ile Lys Ile Gly Ser Val Ala Pro Asp 
    210                 215                 220                 


Thr Ile Asn Asn His Val Lys Thr Cys Arg Glu Glu Gln Lys Asn Leu 
225                 230                 235                 240 


His Phe Phe Ala Pro Glu Tyr Gly Glu Val Thr Asn Val Thr Thr Ala 
                245                 250                 255     


Val Asp Ile Tyr Ser Phe Gly Met Cys Ala Leu Glu Met Ala Val Leu 
            260                 265                 270         


Glu Ile Gln Gly Asn Gly Glu Ser Ser Tyr Val Pro Gln Glu Ala Ile 
        275                 280                 285             


Ser Ser Ala Ile Gln Leu Leu Glu Asp Pro Leu Gln Arg Glu Phe Ile 
    290                 295                 300                 


Gln Lys Cys Leu Gln Ser Glu Pro Ala Arg Arg Pro Thr Ala Arg Glu 
305                 310                 315                 320 


Leu Leu Phe His Pro Ala Leu Phe Glu Val Pro Ser Leu Lys Leu Leu 
                325                 330                 335     


Ala Ala His Cys Ile Val Gly His Gln His Met Ile Pro Glu Asn Ala 
            340                 345                 350         


Leu Glu Glu Ile Thr Lys Asn Met Asp Thr Ser Ala Val Leu Ala Glu 
        355                 360                 365             


Ile Pro Ala Gly Pro Gly Arg Glu Pro Val Gln Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Ser Pro Ala Leu Glu Leu Asp Lys Phe Leu Glu Asp Val Arg Asn Gly 
385                 390                 395                 400 


Ile Tyr Pro Leu Thr Ala Phe Gly Leu Pro Arg Pro Gln Gln Pro Gln 
                405                 410                 415     


Gln Glu Glu Val Thr Ser Pro Val Val Pro Pro Ser Val Lys Thr Pro 
            420                 425                 430         


Thr Pro Glu Pro Ala Glu Val Glu Thr Arg Lys Val Val Leu Met Gln 
        435                 440                 445             


Cys Asn Ile Glu Ser Val Glu Glu Gly Val Lys His His Leu Thr Leu 
    450                 455                 460                 


Leu Leu Lys Leu Glu Asp Lys Leu Asn Arg His Leu Ser Cys Asp Leu 
465                 470                 475                 480 


Met Pro Asn Glu Asn Ile Pro Glu Leu Ala Ala Glu Leu Val Gln Leu 
                485                 490                 495     


Gly Phe Ile Ser Glu Ala Asp Gln Ser Arg Leu Thr Ser Leu Leu Glu 
            500                 505                 510         


Glu Thr Leu Asn Lys Phe Asn Phe Ala Arg Asn Ser Thr Leu Asn Ser 
        515                 520                 525             


Ala Ala Val Thr Val Ser Ser 
    530                 535 


<210> 4761
<211> 193
<212> PRT
<213> Homo sapiens

<400> 4761
Met Asp Ser Thr Leu Ala Val Gln Gln Tyr Ile Gln Gln Asn Ile Arg 
1               5                   10                  15      


Ala Asp Cys Ser Asn Ile Asp Lys Ile Leu Glu Pro Pro Glu Gly Gln 
            20                  25                  30          


Asp Glu Gly Val Trp Lys Tyr Glu His Leu Arg Gln Phe Cys Leu Glu 
        35                  40                  45              


Leu Asn Gly Leu Ala Val Lys Leu Gln Ser Glu Cys His Pro Asp Thr 
    50                  55                  60                  


Cys Thr Gln Met Thr Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala 
65                  70                  75                  80  


His Lys Thr Pro Lys Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr 
                85                  90                  95      


Leu Asp Gly Ala Ala Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser 
            100                 105                 110         


Arg Val Ser Ile Lys Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys 
        115                 120                 125             


Arg Arg Ile Tyr Arg Ile Phe Ser His Ala Tyr Phe His His Arg Gln 
    130                 135                 140                 


Ile Phe Asp Glu Tyr Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr 
145                 150                 155                 160 


Lys Phe Val Met Lys Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val 
                165                 170                 175     


Pro Ile Leu Glu Glu Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu 
            180                 185                 190         


Ala 
    


<210> 4762
<211> 890
<212> PRT
<213> Homo sapiens

<400> 4762
Met Ser Ala Asn Asn Ser Pro Pro Ser Ala Gln Lys Ser Val Leu Pro 
1               5                   10                  15      


Thr Ala Ile Pro Ala Val Leu Pro Ala Ala Ser Pro Cys Ser Ser Pro 
            20                  25                  30          


Lys Thr Gly Leu Ser Ala Arg Leu Ser Asn Gly Ser Phe Ser Ala Pro 
        35                  40                  45              


Ser Leu Thr Asn Ser Arg Gly Ser Val His Thr Val Ser Phe Leu Leu 
    50                  55                  60                  


Gln Ile Gly Leu Thr Arg Glu Ser Val Thr Ile Glu Ala Gln Glu Leu 
65                  70                  75                  80  


Ser Leu Ser Ala Val Lys Asp Leu Val Cys Ser Ile Val Tyr Gln Lys 
                85                  90                  95      


Phe Pro Glu Cys Gly Phe Phe Gly Met Tyr Asp Lys Ile Leu Leu Phe 
            100                 105                 110         


Arg His Asp Met Asn Ser Glu Asn Ile Leu Gln Leu Ile Thr Ser Ala 
        115                 120                 125             


Asp Glu Ile His Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Leu 
    130                 135                 140                 


Ala Thr Val Glu Asp Phe Gln Ile Arg Pro His Thr Leu Tyr Val His 
145                 150                 155                 160 


Ser Tyr Lys Ala Pro Thr Phe Cys Asp Tyr Cys Gly Glu Met Leu Trp 
                165                 170                 175     


Gly Leu Val Arg Gln Gly Leu Lys Cys Glu Gly Cys Gly Leu Asn Tyr 
            180                 185                 190         


His Lys Arg Cys Ala Phe Lys Ile Pro Asn Asn Cys Ser Gly Val Arg 
        195                 200                 205             


Lys Arg Arg Leu Ser Asn Val Ser Leu Pro Gly Pro Gly Leu Ser Val 
    210                 215                 220                 


Pro Arg Pro Leu Gln Pro Glu Tyr Val Ala Leu Pro Ser Glu Glu Ser 
225                 230                 235                 240 


His Val His Gln Glu Pro Ser Lys Arg Ile Pro Ser Trp Ser Gly Arg 
                245                 250                 255     


Pro Ile Trp Met Glu Lys Met Val Met Cys Arg Val Lys Val Pro His 
            260                 265                 270         


Thr Phe Ala Val His Ser Tyr Thr Arg Pro Thr Ile Cys Gln Tyr Cys 
        275                 280                 285             


Lys Arg Leu Leu Lys Gly Leu Phe Arg Gln Gly Met Gln Cys Lys Asp 
    290                 295                 300                 


Cys Lys Phe Asn Cys His Lys Arg Cys Ala Ser Lys Val Pro Arg Asp 
305                 310                 315                 320 


Cys Leu Gly Glu Val Thr Phe Asn Gly Glu Pro Ser Ser Leu Gly Thr 
                325                 330                 335     


Asp Thr Asp Ile Pro Met Asp Ile Asp Asn Asn Asp Ile Asn Ser Asp 
            340                 345                 350         


Ser Ser Arg Gly Leu Asp Asp Thr Glu Glu Pro Ser Pro Pro Glu Asp 
        355                 360                 365             


Lys Met Phe Phe Leu Asp Pro Ser Asp Leu Asp Val Glu Arg Asp Glu 
    370                 375                 380                 


Glu Ala Val Lys Thr Ile Ser Pro Ser Thr Ser Asn Asn Ile Pro Leu 
385                 390                 395                 400 


Met Arg Val Val Gln Ser Ile Lys His Thr Lys Arg Lys Ser Ser Thr 
                405                 410                 415     


Met Val Lys Glu Gly Trp Met Val His Tyr Thr Ser Arg Asp Asn Leu 
            420                 425                 430         


Arg Lys Arg His Tyr Trp Arg Leu Asp Ser Lys Cys Leu Thr Leu Phe 
        435                 440                 445             


Gln Asn Glu Ser Gly Ser Lys Tyr Tyr Lys Glu Ile Pro Leu Ser Glu 
    450                 455                 460                 


Ile Leu Arg Ile Ser Ser Pro Arg Asp Phe Thr Asn Ile Ser Gln Gly 
465                 470                 475                 480 


Ser Asn Pro His Cys Phe Glu Ile Ile Thr Asp Thr Met Val Tyr Phe 
                485                 490                 495     


Val Gly Glu Asn Asn Gly Asp Ser Ser His Asn Pro Val Leu Ala Ala 
            500                 505                 510         


Thr Gly Val Gly Leu Asp Val Ala Gln Ser Trp Glu Lys Ala Ile Arg 
        515                 520                 525             


Gln Ala Leu Met Pro Val Thr Pro Gln Ala Ser Val Cys Thr Ser Pro 
    530                 535                 540                 


Gly Gln Gly Lys Asp His Lys Asp Leu Ser Thr Ser Ile Ser Val Ser 
545                 550                 555                 560 


Asn Cys Gln Ile Gln Glu Asn Val Asp Ile Ser Thr Val Tyr Gln Ile 
                565                 570                 575     


Phe Ala Asp Glu Val Leu Gly Ser Gly Gln Phe Gly Ile Val Tyr Gly 
            580                 585                 590         


Gly Lys His Arg Lys Thr Gly Arg Asp Val Ala Ile Lys Val Ile Asp 
        595                 600                 605             


Lys Met Arg Phe Pro Thr Lys Gln Glu Ser Gln Leu Arg Asn Glu Val 
    610                 615                 620                 


Ala Ile Leu Gln Asn Leu His His Pro Gly Ile Val Asn Leu Glu Cys 
625                 630                 635                 640 


Met Phe Glu Thr Pro Glu Arg Val Phe Val Val Met Glu Lys Leu His 
                645                 650                 655     


Gly Asp Met Leu Glu Met Ile Leu Ser Ser Glu Lys Ser Arg Leu Pro 
            660                 665                 670         


Glu Arg Ile Thr Lys Phe Met Val Thr Gln Ile Leu Val Ala Leu Arg 
        675                 680                 685             


Asn Leu His Phe Lys Asn Ile Val His Cys Asp Leu Lys Pro Glu Asn 
    690                 695                 700                 


Val Leu Leu Ala Ser Ala Glu Pro Phe Pro Gln Val Lys Leu Cys Asp 
705                 710                 715                 720 


Phe Gly Phe Ala Arg Ile Ile Gly Glu Lys Ser Phe Arg Arg Ser Val 
                725                 730                 735     


Val Gly Thr Pro Ala Tyr Leu Ala Pro Glu Val Leu Arg Ser Lys Gly 
            740                 745                 750         


Tyr Asn Arg Ser Leu Asp Met Trp Ser Val Gly Val Ile Ile Tyr Val 
        755                 760                 765             


Ser Leu Ser Gly Thr Phe Pro Phe Asn Glu Asp Glu Asp Ile Asn Asp 
    770                 775                 780                 


Gln Ile Gln Asn Ala Ala Phe Met Tyr Pro Pro Asn Pro Trp Arg Glu 
785                 790                 795                 800 


Ile Ser Gly Glu Ala Ile Asp Leu Ile Asn Asn Leu Leu Gln Val Lys 
                805                 810                 815     


Met Arg Lys Arg Tyr Ser Val Asp Lys Ser Leu Ser His Pro Trp Leu 
            820                 825                 830         


Gln Asp Tyr Gln Thr Trp Leu Asp Leu Arg Glu Phe Glu Thr Arg Ile 
        835                 840                 845             


Gly Glu Arg Tyr Ile Thr His Glu Ser Asp Asp Ala Arg Trp Glu Ile 
    850                 855                 860                 


His Ala Tyr Thr His Asn Leu Val Tyr Pro Lys His Phe Ile Met Ala 
865                 870                 875                 880 


Pro Asn Pro Asp Asp Met Glu Glu Asp Pro 
                885                 890 


<210> 4763
<211> 368
<212> PRT
<213> Homo sapiens

<400> 4763
Met Glu Pro Gly Gln Pro Arg Glu Pro Gln Glu Pro Arg Glu Pro Gly 
1               5                   10                  15      


Pro Gly Ala Glu Thr Ala Ala Ala Pro Val Trp Glu Glu Ala Lys Ile 
            20                  25                  30          


Phe Tyr Asp Asn Leu Ala Pro Lys Lys Lys Pro Lys Ser Pro Lys Pro 
        35                  40                  45              


Gln Asn Ala Val Thr Ile Ala Val Ser Ser Arg Ala Leu Phe Arg Met 
    50                  55                  60                  


Asp Glu Glu Gln Gln Ile Tyr Thr Glu Gln Gly Val Glu Glu Tyr Val 
65                  70                  75                  80  


Arg Tyr Gln Leu Glu His Glu Asn Glu Pro Phe Ser Pro Gly Pro Ala 
                85                  90                  95      


Phe Pro Phe Val Lys Ala Leu Glu Ala Val Asn Arg Arg Leu Arg Glu 
            100                 105                 110         


Leu Tyr Pro Asp Ser Glu Asp Val Phe Asp Ile Val Leu Met Thr Asn 
        115                 120                 125             


Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Ile Asn His Tyr 
    130                 135                 140                 


Asp Leu Phe Ile Glu Arg Phe Cys Met Thr Gly Gly Asn Ser Pro Ile 
145                 150                 155                 160 


Cys Tyr Leu Lys Ala Tyr His Thr Asn Leu Tyr Leu Ser Ala Asp Ala 
                165                 170                 175     


Glu Lys Val Arg Glu Ala Ile Asp Glu Gly Ile Ala Ala Ala Thr Ile 
            180                 185                 190         


Phe Ser Pro Ser Arg Asp Val Val Val Ser Gln Ser Gln Leu Arg Val 
        195                 200                 205             


Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser Glu Arg Ile 
    210                 215                 220                 


Val Lys Ala His Gly Leu Asp Arg Phe Phe Glu His Glu Lys Ala His 
225                 230                 235                 240 


Glu Asn Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe Leu Glu Ala 
                245                 250                 255     


Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ser Lys Gly Leu Arg Leu Glu 
            260                 265                 270         


Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala Ala Ser Ser 
        275                 280                 285             


Gly Ala Arg Ala Leu Lys Thr Leu Arg Ser Trp Gly Leu Glu Thr Asp 
    290                 295                 300                 


Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Gly Pro Leu Leu Glu Lys 
305                 310                 315                 320 


Ile Arg Pro His Ile Phe Phe Asp Asp Gln Met Phe His Val Ala Gly 
                325                 330                 335     


Ala Gln Glu Met Gly Thr Val Ala Ala His Val Pro Tyr Gly Val Ala 
            340                 345                 350         


Gln Thr Pro Arg Arg Thr Ala Pro Ala Lys Gln Ala Pro Ser Ala Gln 
        355                 360                 365             


<210> 4764
<211> 359
<212> PRT
<213> Homo sapiens

<400> 4764
Met Leu Ser Ala Ala Ser Arg Val Val Ser Arg Ala Ala Val His Cys 
1               5                   10                  15      


Ala Leu Arg Ser Pro Pro Pro Glu Ala Arg Ala Leu Ala Met Ser Arg 
            20                  25                  30          


Pro Pro Pro Pro Arg Val Ala Ser Val Leu Gly Thr Met Glu Met Gly 
        35                  40                  45              


Arg Arg Met Asp Ala Pro Ala Ser Ala Ala Ala Val Arg Ala Phe Leu 
    50                  55                  60                  


Glu Arg Gly His Thr Glu Leu Asp Thr Ala Phe Met Tyr Ser Asp Gly 
65                  70                  75                  80  


Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Gly Leu Gly Gly Gly 
                85                  90                  95      


Asp Cys Arg Val Lys Ile Ala Thr Lys Ala Asn Pro Trp Asp Gly Lys 
            100                 105                 110         


Ser Leu Lys Pro Asp Ser Val Arg Ser Gln Leu Glu Thr Ser Leu Lys 
        115                 120                 125             


Arg Leu Gln Cys Pro Gln Val Asp Leu Phe Tyr Leu His Ala Pro Asp 
    130                 135                 140                 


His Gly Thr Pro Val Glu Glu Thr Leu His Ala Cys Gln Arg Leu His 
145                 150                 155                 160 


Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn Tyr Ala Ser Trp 
                165                 170                 175     


Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn Gly Trp Ile Leu 
            180                 185                 190         


Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Thr Thr Arg Gln Val Glu 
        195                 200                 205             


Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu Arg Phe Tyr Ala 
    210                 215                 220                 


Tyr Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Lys Tyr Lys Tyr Glu 
225                 230                 235                 240 


Asp Lys Asp Gly Lys Gln Pro Val Gly Arg Phe Phe Gly Asn Ser Trp 
                245                 250                 255     


Ala Glu Thr Tyr Arg Asn Arg Phe Trp Lys Glu His His Phe Glu Ala 
            260                 265                 270         


Ile Ala Leu Val Glu Lys Ala Leu Gln Ala Ala Tyr Gly Ala Ser Ala 
        275                 280                 285             


Pro Ser Val Thr Ser Ala Ala Leu Arg Trp Met Tyr His His Ser Gln 
    290                 295                 300                 


Leu Gln Gly Ala His Gly Asp Ala Val Ile Leu Gly Met Ser Ser Leu 
305                 310                 315                 320 


Glu Gln Leu Glu Gln Asn Leu Ala Ala Thr Glu Glu Gly Pro Leu Glu 
                325                 330                 335     


Pro Ala Val Val Asp Ala Phe Asn Gln Ala Trp His Leu Val Ala His 
            340                 345                 350         


Glu Cys Pro Asn Tyr Phe Arg 
        355                 


<210> 4765
<211> 186
<212> PRT
<213> Homo sapiens

<400> 4765
Met Asp Ala Asp Ser Asp Val Ala Leu Asp Ile Leu Ile Thr Asn Val 
1               5                   10                  15      


Val Cys Val Phe Arg Thr Arg Cys His Leu Asn Leu Arg Lys Ile Ala 
            20                  25                  30          


Leu Glu Gly Ala Asn Val Ile Tyr Lys Arg Asp Val Gly Lys Val Leu 
        35                  40                  45              


Met Lys Leu Arg Lys Pro Arg Ile Thr Ala Thr Ile Trp Ser Ser Gly 
    50                  55                  60                  


Lys Ile Ile Cys Thr Gly Ala Thr Ser Glu Glu Glu Ala Lys Phe Gly 
65                  70                  75                  80  


Ala Arg Arg Leu Ala Arg Ser Leu Gln Lys Leu Gly Phe Gln Val Ile 
                85                  90                  95      


Phe Thr Asp Phe Lys Val Val Asn Val Leu Ala Val Cys Asn Met Pro 
            100                 105                 110         


Phe Glu Ile Arg Leu Pro Glu Phe Thr Lys Asn Asn Arg Pro His Ala 
        115                 120                 125             


Ser Tyr Glu Pro Glu Leu His Pro Ala Val Cys Tyr Arg Ile Lys Ser 
    130                 135                 140                 


Leu Arg Ala Thr Leu Gln Ile Phe Ser Thr Gly Ser Ile Thr Val Thr 
145                 150                 155                 160 


Gly Pro Asn Val Lys Ala Val Ala Thr Ala Val Glu Gln Ile Tyr Pro 
                165                 170                 175     


Phe Val Phe Glu Ser Arg Lys Glu Ile Leu 
            180                 185     


<210> 4766
<211> 178
<212> PRT
<213> Homo sapiens

<400> 4766
Met Ala Ala Pro Leu Gly Gly Met Phe Ser Gly Gln Pro Pro Gly Pro 
1               5                   10                  15      


Pro Gln Ala Pro Pro Gly Leu Pro Gly Gln Ala Ser Leu Leu Gln Ala 
            20                  25                  30          


Ala Pro Gly Ala Pro Arg Pro Ser Ser Ser Thr Leu Val Asp Glu Leu 
        35                  40                  45              


Glu Ser Ser Phe Glu Ala Cys Phe Ala Ser Leu Val Ser Gln Asp Tyr 
    50                  55                  60                  


Val Asn Gly Thr Asp Gln Glu Glu Ile Arg Thr Gly Val Asp Gln Cys 
65                  70                  75                  80  


Ile Gln Lys Phe Leu Asp Ile Ala Arg Gln Thr Glu Cys Phe Phe Leu 
                85                  90                  95      


Gln Lys Arg Leu Gln Leu Ser Val Gln Lys Pro Glu Gln Val Ile Lys 
            100                 105                 110         


Glu Asp Val Ser Glu Leu Arg Asn Glu Leu Gln Arg Lys Asp Ala Leu 
        115                 120                 125             


Val Gln Lys His Leu Thr Lys Leu Arg His Trp Gln Gln Val Leu Glu 
    130                 135                 140                 


Asp Ile Asn Val Gln His Lys Lys Pro Ala Asp Ile Pro Gln Gly Ser 
145                 150                 155                 160 


Leu Ala Tyr Leu Glu Gln Ala Ser Ala Asn Ile Pro Ala Pro Leu Lys 
                165                 170                 175     


Pro Thr 
        


<210> 4767
<211> 245
<212> PRT
<213> Homo sapiens

<400> 4767
Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
65                  70                  75                  80  


Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                85                  90                  95      


Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Asp Asn 
    130                 135                 140                 


Ser Gln Gly Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu 
        195                 200                 205             


Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala 
225                 230                 235                 240 


Glu Gly Ala Glu Asn 
                245 


<210> 4768
<211> 177
<212> PRT
<213> Homo sapiens

<400> 4768
Met Pro Gly Leu Thr Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val 
1               5                   10                  15      


Lys Gly Gly Glu Thr Val Met Val Asn Ala Ala Ala Gly Ala Val Gly 
            20                  25                  30          


Ser Val Val Gly Gln Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly 
        35                  40                  45              


Ala Val Gly Ser Asp Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe 
    50                  55                  60                  


Asp Val Val Phe Asn Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu 
65                  70                  75                  80  


Lys Lys Ala Ser Pro Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly 
                85                  90                  95      


Gly Glu Phe Ser Asn Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg 
            100                 105                 110         


Ile Ala Ile Cys Gly Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu 
        115                 120                 125             


Pro Pro Gly Pro Pro Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met 
    130                 135                 140                 


Glu Ala Phe Val Val Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala 
145                 150                 155                 160 


Leu Lys Asp Leu Leu Lys Trp Val Leu Glu Leu Pro Tyr Phe Val Ile 
                165                 170                 175     


Asp 
    


<210> 4769
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 4769
Met Phe Gly Ala Gly Asp Glu Asp Asp Thr Asp Phe Leu Ser Pro Ser 
1               5                   10                  15      


Gly Gly Ala Arg Leu Ala Ser Leu Phe Gly Leu Asp Gln Ala Ala Ala 
            20                  25                  30          


Gly His Gly Asn Glu Phe Phe Gln Tyr Thr Ala Pro Lys Gln Pro Lys 
        35                  40                  45              


Lys Gly Gln Gly Thr Ala Ala Thr Gly Asn Gln Ala Thr Pro Lys Thr 
    50                  55                  60                  


Ala Pro Ala Thr Met Ser Thr Pro Thr Ile Leu Val Ala Thr Ala Val 
65                  70                  75                  80  


His Ala Tyr Arg Tyr Thr Asn Gly Gln Tyr Val Lys Gln Gly Lys Phe 
                85                  90                  95      


Gly Ala Ala Val Leu Gly Asn His Thr Ala Arg Glu Tyr Arg Ile Leu 
            100                 105                 110         


Leu Tyr Ile Ser Gln Gln Gln Pro Val Thr Val Ala Arg Ile His Val 
        115                 120                 125             


Asn Phe Glu Leu Met Val Arg Pro Asn Asn Tyr Ser Thr Phe Tyr Asp 
    130                 135                 140                 


Asp Gln Arg Gln Asn Trp Ser Ile Met Phe Glu Ser Glu Lys Ala Ala 
145                 150                 155                 160 


Val Glu Phe Asn Lys Gln Val Cys Ile Ala Lys Cys Asn Ser Thr Ser 
                165                 170                 175     


Ser Leu Asp Ala Val Leu Ser Gln Asp Leu Ile Val Ala Asp Gly Pro 
            180                 185                 190         


Ala Val Glu Val Gly Asp Ser Leu Glu Val Ala Tyr Thr Gly Trp Leu 
        195                 200                 205             


Phe Gln Asn His Val Leu Gly Gln Val Phe Asp Ser Thr Ala Asn Lys 
    210                 215                 220                 


Asp Lys Leu Leu Arg Leu Lys Leu Gly Ser Gly Lys Val Ile Lys Gly 
225                 230                 235                 240 


Trp Glu Asp Gly Met Leu Gly Met Lys Lys Gly Gly Lys Arg Leu Leu 
                245                 250                 255     


Ile Val Pro Pro Ala Cys Ala Val Gly Ser Glu Gly Val Ile Gly Trp 
            260                 265                 270         


Thr Gln Ala Thr Asp Ser Ile Leu Val Phe Glu Val Glu Val Arg Arg 
        275                 280                 285             


Val Lys Phe Ala Arg Asp Ser Gly Ser Asp Gly His Ser Val Ser Ser 
    290                 295                 300                 


Arg Asp Ser Ala Ala Pro Ser Pro Ile Pro Gly Ala Asp Asn Leu Ser 
305                 310                 315                 320 


Ala Asp Pro Val Val Ser Pro Pro Thr Ser Ile Pro Phe Lys Ser Gly 
                325                 330                 335     


Glu Pro Ala Leu Arg Thr Lys Ser Asn Ser Leu Ser Glu Gln Leu Ala 
            340                 345                 350         


Ile Asn Thr Ser Pro Asp Ala Val Lys Ala Lys Leu Ile Ser Arg Met 
        355                 360                 365             


Ala Lys Met Gly Gln Pro Met Leu Pro Ile Leu Pro Pro Gln Leu Asp 
    370                 375                 380                 


Ser Asn Asp Ser Glu Ile Glu Asp Val Asn Thr Leu Gln Gly Gly Gly 
385                 390                 395                 400 


Gln Pro Val Val Thr Pro Ser Val Gln Pro Ser Leu His Pro Ala His 
                405                 410                 415     


Pro Ala Leu Pro Gln Met Thr Ser Gln Ala Pro Gln Pro Ser Val Thr 
            420                 425                 430         


Gly Leu Gln Ala Pro Ser Ala Ala Leu Met Gln Val Ser Ser Leu Asp 
        435                 440                 445             


Ser His Ser Ala Val Ser Gly Asn Ala Gln Ser Phe Gln Pro Tyr Ala 
    450                 455                 460                 


Gly Met Gln Ala Tyr Ala Tyr Pro Gln Ala Ser Ala Val Thr Ser Gln 
465                 470                 475                 480 


Leu Gln Pro Val Arg Pro Leu Tyr Pro Ala Pro Leu Ser Gln Pro Pro 
                485                 490                 495     


His Phe Gln Gly Ser Gly Asp Met Ala Ser Phe Leu Met Thr Glu Ala 
            500                 505                 510         


Arg Gln His Asn Thr Glu Ile Arg Met Ala Val Ser Lys Val Ala Asp 
        515                 520                 525             


Lys Met Asp His Leu Met Thr Lys Val Glu Glu Leu Gln Lys His Ser 
    530                 535                 540                 


Ala Gly Asn Ser Met Leu Ile Pro Ser Met Ser Val Thr Met Glu Thr 
545                 550                 555                 560 


Ser Met Ile Met Ser Asn Ile Gln Arg Ile Ile Gln Glu Asn Glu Arg 
                565                 570                 575     


Leu Lys Gln Glu Ile Leu Glu Lys Ser Asn Arg Ile Glu Glu Gln Asn 
            580                 585                 590         


Asp Lys Ile Ser Glu Leu Ile Glu Arg Asn Gln Arg Tyr Val Glu Gln 
        595                 600                 605             


Ser Asn Leu Met Met Glu Lys Arg Asn Asn Ser Leu Gln Thr Ala Thr 
    610                 615                 620                 


Glu Asn Thr Gln Ala Arg Val Leu His Ala Glu Gln Glu Lys Ala Lys 
625                 630                 635                 640 


Val Thr Glu Glu Leu Ala Ala Ala Thr Ala Gln Val Ser His Leu Gln 
                645                 650                 655     


Leu Lys Met Thr Ala His Gln Lys Lys Glu Thr Glu Leu Gln Met Gln 
            660                 665                 670         


Leu Thr Glu Ser Leu Lys Glu Thr Asp Leu Leu Arg Gly Gln Leu Thr 
        675                 680                 685             


Lys Val Gln Ala Lys Leu Ser Glu Leu Gln Glu Thr Ser Glu Gln Ala 
    690                 695                 700                 


Gln Ser Lys Phe Lys Ser Glu Lys Gln Asn Arg Lys Gln Leu Glu Leu 
705                 710                 715                 720 


Lys Val Thr Ser Leu Glu Glu Glu Leu Thr Asp Leu Arg Val Glu Lys 
                725                 730                 735     


Glu Ser Leu Glu Lys Asn Leu Ser Glu Arg Lys Lys Lys Ser Ala Gln 
            740                 745                 750         


Glu Arg Ser Gln Ala Glu Glu Glu Ile Asp Glu Ile Arg Lys Ser Tyr 
        755                 760                 765             


Gln Glu Glu Leu Asp Lys Leu Arg Gln Leu Leu Lys Lys Thr Arg Val 
    770                 775                 780                 


Ser Thr Asp Gln Ala Ala Ala Glu Gln Leu Ser Leu Val Gln Ala Glu 
785                 790                 795                 800 


Leu Gln Thr Gln Trp Glu Ala Lys Cys Glu His Leu Leu Ala Ser Ala 
                805                 810                 815     


Lys Asp Glu His Leu Gln Gln Tyr Gln Glu Val Cys Ala Gln Arg Asp 
            820                 825                 830         


Ala Tyr Gln Gln Lys Leu Val Gln Leu Gln Glu Lys Cys Leu Ala Leu 
        835                 840                 845             


Gln Ala Gln Ile Thr Ala Leu Thr Lys Gln Asn Glu Gln His Ile Lys 
    850                 855                 860                 


Glu Leu Glu Lys Asn Lys Ser Gln Met Ser Gly Val Glu Ala Ala Ala 
865                 870                 875                 880 


Ser Asp Pro Ser Glu Lys Val Lys Lys Ile Met Asn Gln Val Phe Gln 
                885                 890                 895     


Ser Leu Arg Arg Glu Phe Glu Leu Glu Glu Ser Tyr Asn Gly Arg Thr 
            900                 905                 910         


Ile Leu Gly Thr Ile Met Asn Thr Ile Lys Met Val Thr Leu Gln Leu 
        915                 920                 925             


Leu Asn Gln Gln Glu Gln Glu Lys Glu Glu Ser Ser Ser Glu Glu Glu 
    930                 935                 940                 


Glu Glu Lys Ala Glu Glu Arg Pro Arg Arg Pro Ser Gln Glu Gln Ser 
945                 950                 955                 960 


Ala Ser Ala Ser Ser Gly Gln Pro Gln Ala Pro Leu Asn Arg Glu Arg 
                965                 970                 975     


Pro Glu Ser Pro Met Val Pro Ser Glu Gln Val Val Glu Glu Ala Val 
            980                 985                 990         


Pro Leu Pro Pro Gln Ala Leu Thr  Thr Ser Gln Asp Gly  His Arg Arg 
        995                 1000                 1005             


Lys Gly  Asp Ser Glu Ala Glu  Ala Leu Ser Glu Ile  Lys Asp Gly 
    1010                 1015                 1020             


Ser Leu  Pro Pro Glu Leu Ser  Cys Ile Pro Ser His  Arg Val Leu 
    1025                 1030                 1035             


Gly Pro  Pro Thr Ser Ile Pro  Pro Glu Pro Leu Gly  Pro Val Ser 
    1040                 1045                 1050             


Met Asp  Ser Glu Cys Glu Glu  Ser Leu Ala Ala Ser  Pro Met Ala 
    1055                 1060                 1065             


Ala Lys  Pro Asp Asn Pro Ser  Gly Lys Val Cys Val  Arg Glu Val 
    1070                 1075                 1080             


Ala Pro  Asp Gly Pro Leu Gln  Glu Ser Ser Thr Arg  Leu Ser Leu 
    1085                 1090                 1095             


Thr Ser  Asp Pro Glu Glu Gly  Asp Pro Leu Ala Leu  Gly Pro Glu 
    1100                 1105                 1110             


Ser Pro  Gly Glu Pro Gln Pro  Pro Gln Leu Lys Lys  Asp Asp Val 
    1115                 1120                 1125             


Thr Ser  Ser Thr Gly Pro His  Lys Glu Leu Ser Ser  Thr Glu Ala 
    1130                 1135                 1140             


Gly Ser  Thr Val Ala Gly Ala  Ala Leu Arg Pro Ser  His His Ser 
    1145                 1150                 1155             


Gln Arg  Ser Ser Leu Ser Gly  Asp Glu Glu Asp Glu  Leu Phe Lys 
    1160                 1165                 1170             


Gly Ala  Thr Leu Lys Ala Leu  Arg Pro Lys Ala Gln  Pro Glu Glu 
    1175                 1180                 1185             


Glu Asp  Glu Asp Glu Val Ser  Met Lys Gly Arg Pro  Pro Pro Thr 
    1190                 1195                 1200             


Pro Leu  Phe Gly Asp Asp Asp  Asp Asp Asp Asp Ile  Asp Trp Leu 
    1205                 1210                 1215             


Gly 
    


<210> 4770
<211> 2325
<212> PRT
<213> Homo sapiens

<400> 4770
Met Lys Lys Gly Ser Gln Gln Lys Ile Phe Ser Lys Ala Lys Ile Pro 
1               5                   10                  15      


Ser Ser Ser His Ser Pro Ile Pro Ser Ser Met Ser Asn Met Arg Ser 
            20                  25                  30          


Arg Ser Leu Ser Pro Leu Ile Gly Ser Glu Thr Leu Pro Phe His Ser 
        35                  40                  45              


Gly Gly Gln Trp Cys Glu Gln Val Glu Ile Ala Asp Glu Asn Asn Met 
    50                  55                  60                  


Leu Leu Asp Tyr Gln Asp His Lys Gly Ala Asp Ser His Ala Gly Val 
65                  70                  75                  80  


Arg Tyr Ile Thr Glu Ala Leu Ile Lys Lys Leu Thr Lys Gln Asp Asn 
                85                  90                  95      


Leu Ala Leu Ile Lys Ser Leu Asn Leu Ser Leu Ser Lys Asp Gly Gly 
            100                 105                 110         


Lys Lys Phe Lys Tyr Ile Glu Asn Leu Glu Lys Cys Val Lys Leu Glu 
        115                 120                 125             


Val Leu Asn Leu Ser Tyr Asn Leu Ile Gly Lys Ile Glu Lys Leu Asp 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Leu Asn Leu Ser Tyr Asn Lys Ile Ser 
145                 150                 155                 160 


Lys Ile Glu Gly Ile Glu Asn Met Cys Asn Leu Gln Lys Leu Asn Leu 
                165                 170                 175     


Ala Gly Asn Glu Ile Glu His Ile Pro Val Trp Leu Gly Lys Lys Leu 
            180                 185                 190         


Lys Ser Leu Arg Val Leu Asn Leu Lys Gly Asn Lys Ile Ser Ser Leu 
        195                 200                 205             


Gln Asp Ile Ser Lys Leu Lys Pro Leu Gln Asp Leu Ile Ser Leu Ile 
    210                 215                 220                 


Leu Val Glu Asn Pro Val Val Thr Leu Pro His Tyr Leu Gln Phe Thr 
225                 230                 235                 240 


Ile Phe His Leu Arg Ser Leu Glu Ser Leu Glu Gly Gln Pro Val Thr 
                245                 250                 255     


Thr Gln Asp Arg Gln Glu Ala Phe Glu Arg Phe Ser Leu Glu Glu Val 
            260                 265                 270         


Glu Arg Leu Glu Arg Asp Leu Glu Lys Lys Met Ile Glu Thr Glu Glu 
        275                 280                 285             


Leu Lys Ser Lys Gln Thr Arg Phe Leu Glu Glu Ile Lys Asn Gln Asp 
    290                 295                 300                 


Lys Leu Asn Lys Ser Leu Lys Glu Glu Ala Met Leu Gln Lys Gln Ser 
305                 310                 315                 320 


Cys Glu Glu Leu Lys Ser Asp Leu Asn Thr Lys Asn Glu Leu Leu Lys 
                325                 330                 335     


Gln Lys Thr Ile Glu Leu Thr Arg Ala Cys Gln Lys Gln Tyr Glu Leu 
            340                 345                 350         


Glu Gln Glu Leu Ala Phe Tyr Lys Ile Asp Ala Lys Phe Glu Pro Leu 
        355                 360                 365             


Asn Tyr Tyr Pro Ser Glu Tyr Ala Glu Ile Asp Lys Ala Pro Asp Glu 
    370                 375                 380                 


Ser Pro Tyr Ile Gly Lys Ser Arg Tyr Lys Arg Asn Met Phe Ala Thr 
385                 390                 395                 400 


Glu Ser Tyr Ile Ile Asp Ser Ala Gln Ala Val Gln Ile Lys Lys Met 
                405                 410                 415     


Glu Pro Asp Glu Gln Leu Arg Asn Asp His Met Asn Leu Arg Gly His 
            420                 425                 430         


Thr Pro Leu Asp Thr Gln Leu Glu Asp Lys Glu Lys Lys Ile Ser Ala 
        435                 440                 445             


Ala Gln Thr Arg Leu Ser Glu Leu His Asp Glu Ile Glu Lys Ala Glu 
    450                 455                 460                 


Gln Gln Ile Leu Arg Ala Thr Glu Glu Phe Lys Gln Leu Glu Glu Ala 
465                 470                 475                 480 


Ile Gln Leu Lys Lys Ile Ser Glu Ala Gly Lys Asp Leu Leu Tyr Lys 
                485                 490                 495     


Gln Leu Ser Gly Arg Leu Gln Leu Val Asn Lys Leu Arg Gln Glu Ala 
            500                 505                 510         


Leu Asp Leu Glu Leu Gln Met Glu Lys Gln Lys Gln Glu Ile Ala Gly 
        515                 520                 525             


Lys Gln Lys Glu Ile Lys Asp Leu Gln Ile Ala Ile Asp Ser Leu Asp 
    530                 535                 540                 


Ser Lys Asp Pro Lys His Ser His Met Lys Ala Gln Lys Ser Gly Lys 
545                 550                 555                 560 


Glu Gln Gln Leu Asp Ile Met Asn Lys Gln Tyr Gln Gln Leu Glu Ser 
                565                 570                 575     


Arg Leu Asp Glu Ile Leu Ser Arg Ile Ala Lys Glu Thr Glu Glu Ile 
            580                 585                 590         


Lys Asp Leu Glu Glu Gln Leu Thr Glu Gly Gln Ile Ala Ala Asn Glu 
        595                 600                 605             


Ala Leu Lys Lys Asp Leu Glu Gly Val Ile Ser Gly Leu Gln Glu Tyr 
    610                 615                 620                 


Leu Gly Thr Ile Lys Gly Gln Ala Thr Gln Ala Gln Asn Glu Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Asp Glu Lys Glu Thr Leu Leu Gln Arg Leu Thr Glu Val 
                645                 650                 655     


Glu Gln Glu Arg Asp Gln Leu Glu Ile Val Ala Met Asp Ala Glu Asn 
            660                 665                 670         


Met Arg Lys Glu Leu Ala Glu Leu Glu Ser Ala Leu Gln Glu Gln His 
        675                 680                 685             


Glu Val Asn Ala Ser Leu Gln Gln Thr Gln Gly Asp Leu Ser Ala Tyr 
    690                 695                 700                 


Glu Ala Glu Leu Glu Ala Arg Leu Asn Leu Arg Asp Ala Glu Ala Asn 
705                 710                 715                 720 


Gln Leu Lys Glu Glu Leu Glu Lys Val Thr Arg Leu Thr Gln Leu Glu 
                725                 730                 735     


Gln Ser Ala Leu Gln Ala Glu Leu Glu Lys Glu Arg Gln Ala Leu Lys 
            740                 745                 750         


Asn Ala Leu Gly Lys Ala Gln Phe Ser Glu Glu Lys Glu Gln Glu Asn 
        755                 760                 765             


Ser Glu Leu His Ala Lys Leu Lys His Leu Gln Asp Asp Asn Asn Leu 
    770                 775                 780                 


Leu Lys Gln Gln Leu Lys Asp Phe Gln Asn His Leu Asn His Val Val 
785                 790                 795                 800 


Asp Gly Leu Val Arg Pro Glu Glu Val Ala Ala Arg Val Asp Glu Leu 
                805                 810                 815     


Arg Arg Lys Leu Lys Leu Gly Thr Gly Glu Met Asn Ile His Ser Pro 
            820                 825                 830         


Ser Asp Val Leu Gly Lys Ser Leu Ala Asp Leu Gln Lys Gln Phe Ser 
        835                 840                 845             


Glu Ile Leu Ala Arg Ser Lys Trp Glu Arg Asp Glu Ala Gln Val Arg 
    850                 855                 860                 


Glu Arg Lys Leu Gln Glu Glu Met Ala Leu Gln Gln Glu Lys Leu Ala 
865                 870                 875                 880 


Thr Gly Gln Glu Glu Phe Arg Gln Ala Cys Glu Arg Ala Leu Glu Ala 
                885                 890                 895     


Arg Met Asn Phe Asp Lys Arg Gln His Glu Ala Arg Ile Gln Gln Met 
            900                 905                 910         


Glu Asn Glu Ile His Tyr Leu Gln Glu Asn Leu Lys Ser Met Glu Glu 
        915                 920                 925             


Ile Gln Gly Leu Thr Asp Leu Gln Leu Gln Glu Ala Asp Glu Glu Lys 
    930                 935                 940                 


Glu Arg Ile Leu Ala Gln Leu Arg Glu Leu Glu Lys Lys Lys Lys Leu 
945                 950                 955                 960 


Glu Asp Ala Lys Ser Gln Glu Gln Val Phe Gly Leu Asp Lys Glu Leu 
                965                 970                 975     


Lys Lys Leu Lys Lys Ala Val Ala Thr Ser Asp Lys Leu Ala Thr Ala 
            980                 985                 990         


Glu Leu Thr Ile Ala Lys Asp Gln  Leu Lys Ser Leu His  Gly Thr Val 
        995                 1000                 1005             


Met Lys  Ile Asn Gln Glu Arg  Ala Glu Glu Leu Gln  Glu Ala Glu 
    1010                 1015                 1020             


Arg Phe  Ser Arg Lys Ala Ala  Gln Ala Ala Arg Asp  Leu Thr Arg 
    1025                 1030                 1035             


Ala Glu  Ala Glu Ile Glu Leu  Leu Gln Asn Leu Leu  Arg Gln Lys 
    1040                 1045                 1050             


Gly Glu  Gln Phe Arg Leu Glu  Met Glu Lys Thr Gly  Val Gly Thr 
    1055                 1060                 1065             


Gly Ala  Asn Ser Gln Val Leu  Glu Ile Glu Lys Leu  Asn Glu Thr 
    1070                 1075                 1080             


Met Glu  Arg Gln Arg Thr Glu  Ile Ala Arg Leu Gln  Asn Val Leu 
    1085                 1090                 1095             


Asp Leu  Thr Gly Ser Asp Asn  Lys Gly Gly Phe Glu  Asn Val Leu 
    1100                 1105                 1110             


Glu Glu  Ile Ala Glu Leu Arg  Arg Glu Val Ser Tyr  Gln Asn Asp 
    1115                 1120                 1125             


Tyr Ile  Ser Ser Met Ala Asp  Pro Phe Lys Arg Arg  Gly Tyr Trp 
    1130                 1135                 1140             


Tyr Phe  Met Pro Pro Pro Pro  Ser Ser Lys Val Ser  Ser His Ser 
    1145                 1150                 1155             


Ser Gln  Ala Thr Lys Asp Ser  Gly Val Gly Leu Lys  Tyr Ser Ala 
    1160                 1165                 1170             


Ser Thr  Pro Val Arg Lys Pro  Arg Pro Gly Gln Gln  Asp Gly Lys 
    1175                 1180                 1185             


Glu Gly  Ser Gln Pro Pro Pro  Ala Ser Gly Tyr Trp  Val Tyr Ser 
    1190                 1195                 1200             


Pro Ile  Arg Ser Gly Leu His  Lys Leu Phe Pro Ser  Arg Asp Ala 
    1205                 1210                 1215             


Asp Ser  Gly Gly Asp Ser Gln  Glu Glu Ser Glu Leu  Asp Asp Gln 
    1220                 1225                 1230             


Glu Glu  Pro Pro Phe Val Pro  Pro Pro Gly Tyr Met  Met Tyr Thr 
    1235                 1240                 1245             


Val Leu  Pro Asp Gly Ser Pro  Val Pro Gln Gly Met  Ala Leu Tyr 
    1250                 1255                 1260             


Ala Pro  Pro Pro Pro Leu Pro  Asn Asn Ser Arg Pro  Leu Thr Pro 
    1265                 1270                 1275             


Gly Thr  Val Val Tyr Gly Pro  Pro Pro Ala Gly Ala  Pro Met Val 
    1280                 1285                 1290             


Tyr Gly  Pro Pro Pro Pro Asn  Phe Ser Ile Pro Phe  Ile Pro Met 
    1295                 1300                 1305             


Gly Val  Leu His Cys Asn Val  Pro Glu His His Asn  Leu Glu Asn 
    1310                 1315                 1320             


Glu Val  Ser Arg Leu Glu Asp  Ile Met Gln His Leu  Lys Ser Lys 
    1325                 1330                 1335             


Lys Arg  Glu Glu Arg Trp Met  Arg Ala Ser Lys Arg  Gln Ser Glu 
    1340                 1345                 1350             


Lys Glu  Met Glu Glu Leu His  His Asn Ile Asp Asp  Leu Leu Gln 
    1355                 1360                 1365             


Glu Lys  Lys Ser Leu Glu Cys  Glu Val Glu Glu Leu  His Arg Thr 
    1370                 1375                 1380             


Val Gln  Lys Arg Gln Gln Gln  Lys Asp Phe Ile Asp  Gly Asn Val 
    1385                 1390                 1395             


Glu Ser  Leu Met Thr Glu Leu  Glu Ile Glu Lys Ser  Leu Lys His 
    1400                 1405                 1410             


His Glu  Asp Ile Val Asp Glu  Ile Glu Cys Ile Glu  Lys Thr Leu 
    1415                 1420                 1425             


Leu Lys  Arg Arg Ser Glu Leu  Arg Glu Ala Asp Arg  Leu Leu Ala 
    1430                 1435                 1440             


Glu Ala  Glu Ser Glu Leu Ser  Cys Thr Lys Glu Lys  Thr Lys Asn 
    1445                 1450                 1455             


Ala Val  Glu Lys Phe Thr Asp  Ala Lys Arg Ser Leu  Leu Gln Thr 
    1460                 1465                 1470             


Glu Ser  Asp Ala Glu Glu Leu  Glu Arg Arg Ala Gln  Glu Thr Ala 
    1475                 1480                 1485             


Val Asn  Leu Val Lys Ala Asp  Gln Gln Leu Arg Ser  Leu Gln Ala 
    1490                 1495                 1500             


Asp Ala  Lys Asp Leu Glu Gln  His Lys Ile Lys Gln  Glu Glu Ile 
    1505                 1510                 1515             


Leu Lys  Glu Ile Asn Lys Ile  Val Ala Ala Lys Asp  Ser Asp Phe 
    1520                 1525                 1530             


Gln Cys  Leu Ser Lys Lys Lys  Glu Lys Leu Thr Glu  Glu Leu Gln 
    1535                 1540                 1545             


Lys Leu  Gln Lys Asp Ile Glu  Met Ala Glu Arg Asn  Glu Asp His 
    1550                 1555                 1560             


His Leu  Gln Val Leu Lys Glu  Ser Glu Val Leu Leu  Gln Ala Lys 
    1565                 1570                 1575             


Arg Ala  Glu Leu Glu Lys Leu  Lys Ser Gln Val Thr  Ser Gln Gln 
    1580                 1585                 1590             


Gln Glu  Met Ala Val Leu Asp  Arg Gln Leu Gly His  Lys Lys Glu 
    1595                 1600                 1605             


Glu Leu  His Leu Leu Gln Gly  Ser Met Val Gln Ala  Lys Ala Asp 
    1610                 1615                 1620             


Leu Gln  Glu Ala Leu Arg Leu  Gly Glu Thr Glu Val  Thr Glu Lys 
    1625                 1630                 1635             


Cys Asn  His Ile Arg Glu Val  Lys Ser Leu Leu Glu  Glu Leu Ser 
    1640                 1645                 1650             


Phe Gln  Lys Gly Glu Leu Asn  Val Gln Ile Ser Glu  Arg Lys Thr 
    1655                 1660                 1665             


Gln Leu  Thr Leu Ile Lys Gln  Glu Ile Glu Lys Glu  Glu Glu Asn 
    1670                 1675                 1680             


Leu Gln  Val Val Leu Arg Gln  Met Ser Lys His Lys  Thr Glu Leu 
    1685                 1690                 1695             


Lys Asn  Ile Leu Asp Met Leu  Gln Leu Glu Asn His  Glu Leu Gln 
    1700                 1705                 1710             


Gly Leu  Lys Leu Gln His Asp  Gln Arg Val Ser Glu  Leu Glu Lys 
    1715                 1720                 1725             


Thr Gln  Val Ala Val Leu Glu  Glu Lys Leu Glu Leu  Glu Asn Leu 
    1730                 1735                 1740             


Gln Gln  Ile Ser Gln Gln Gln  Lys Gly Glu Ile Glu  Trp Gln Lys 
    1745                 1750                 1755             


Gln Leu  Leu Glu Arg Asp Lys  Arg Glu Ile Glu Arg  Met Thr Ala 
    1760                 1765                 1770             


Glu Ser  Arg Ala Leu Gln Ser  Cys Val Glu Cys Leu  Ser Lys Glu 
    1775                 1780                 1785             


Lys Glu  Asp Leu Gln Glu Lys  Cys Asp Ile Trp Glu  Lys Lys Leu 
    1790                 1795                 1800             


Ala Gln  Thr Lys Arg Val Leu  Ala Ala Ala Glu Glu  Asn Ser Lys 
    1805                 1810                 1815             


Met Glu  Gln Ser Asn Leu Glu  Lys Leu Glu Leu Asn  Val Arg Lys 
    1820                 1825                 1830             


Leu Gln  Gln Glu Leu Asp Gln  Leu Asn Arg Asp Lys  Leu Ser Leu 
    1835                 1840                 1845             


His Asn  Asp Ile Ser Ala Met  Gln Gln Gln Leu Gln  Glu Lys Arg 
    1850                 1855                 1860             


Glu Ala  Val Asn Ser Leu Gln  Glu Glu Leu Ala Asn  Val Gln Asp 
    1865                 1870                 1875             


His Leu  Asn Leu Ala Lys Gln  Asp Leu Leu His Thr  Thr Lys His 
    1880                 1885                 1890             


Gln Asp  Val Leu Leu Ser Glu  Gln Thr Arg Leu Gln  Lys Asp Ile 
    1895                 1900                 1905             


Ser Glu  Trp Ala Asn Arg Phe  Glu Asp Cys Gln Lys  Glu Glu Glu 
    1910                 1915                 1920             


Thr Lys  Gln Gln Gln Leu Gln  Val Leu Gln Asn Glu  Ile Glu Glu 
    1925                 1930                 1935             


Asn Lys  Leu Lys Leu Val Gln  Gln Glu Met Met Phe  Gln Arg Leu 
    1940                 1945                 1950             


Gln Lys  Glu Arg Glu Ser Glu  Glu Ser Lys Leu Glu  Thr Ser Lys 
    1955                 1960                 1965             


Val Thr  Leu Lys Glu Gln Gln  His Gln Leu Glu Lys  Glu Leu Thr 
    1970                 1975                 1980             


Asp Gln  Lys Ser Lys Leu Asp  Gln Val Leu Ser Lys  Val Leu Ala 
    1985                 1990                 1995             


Ala Glu  Glu Arg Val Arg Thr  Leu Gln Glu Glu Glu  Arg Trp Cys 
    2000                 2005                 2010             


Glu Ser  Leu Glu Lys Thr Leu  Ser Gln Thr Lys Arg  Gln Leu Ser 
    2015                 2020                 2025             


Glu Arg  Glu Gln Gln Leu Val  Glu Lys Ser Gly Glu  Leu Leu Ala 
    2030                 2035                 2040             


Leu Gln  Lys Glu Ala Asp Ser  Met Arg Ala Asp Phe  Ser Leu Leu 
    2045                 2050                 2055             


Arg Asn  Gln Phe Leu Thr Glu  Arg Lys Lys Ala Glu  Lys Gln Val 
    2060                 2065                 2070             


Ala Ser  Leu Lys Glu Ala Leu  Lys Ile Gln Arg Ser  Gln Leu Glu 
    2075                 2080                 2085             


Lys Asn  Leu Leu Glu Gln Lys  Gln Glu Asn Ser Cys  Ile Gln Lys 
    2090                 2095                 2100             


Glu Met  Ala Thr Ile Glu Leu  Val Ala Gln Asp Asn  His Glu Arg 
    2105                 2110                 2115             


Ala Arg  Arg Leu Met Lys Glu  Leu Asn Gln Met Gln  Tyr Glu Tyr 
    2120                 2125                 2130             


Thr Glu  Leu Lys Lys Gln Met  Ala Asn Gln Lys Asp  Leu Glu Arg 
    2135                 2140                 2145             


Arg Gln  Met Glu Ile Ser Asp  Ala Met Arg Thr Leu  Lys Ser Glu 
    2150                 2155                 2160             


Val Lys  Asp Glu Ile Arg Thr  Ser Leu Lys Asn Leu  Asn Gln Phe 
    2165                 2170                 2175             


Leu Pro  Glu Leu Pro Ala Asp  Leu Glu Ala Ile Leu  Glu Arg Asn 
    2180                 2185                 2190             


Glu Asn  Leu Glu Gly Glu Leu  Glu Ser Leu Lys Glu  Asn Leu Pro 
    2195                 2200                 2205             


Phe Thr  Met Asn Glu Gly Pro  Phe Glu Glu Lys Leu  Asn Phe Ser 
    2210                 2215                 2220             


Gln Val  His Ile Met Asp Glu  His Trp Arg Gly Glu  Ala Leu Arg 
    2225                 2230                 2235             


Glu Lys  Leu Arg His Arg Glu  Asp Arg Leu Lys Ala  Gln Leu Arg 
    2240                 2245                 2250             


His Cys  Met Ser Lys Gln Ala  Glu Val Leu Ile Lys  Gly Lys Arg 
    2255                 2260                 2265             


Gln Thr  Glu Gly Thr Leu His  Ser Leu Arg Arg Gln  Val Asp Ala 
    2270                 2275                 2280             


Leu Gly  Glu Leu Val Thr Ser  Thr Ser Ala Asp Ser  Ala Ser Ser 
    2285                 2290                 2295             


Pro Ser  Leu Ser Gln Leu Glu  Ser Ser Leu Thr Glu  Asp Ser Gln 
    2300                 2305                 2310             


Leu Gly  Gln Asn Gln Glu Lys  Asn Ala Ser Ala Arg  
    2315                 2320                 2325 


<210> 4771
<211> 936
<212> PRT
<213> Homo sapiens

<400> 4771
Met Glu Pro Asp Ile Ile Arg Met Tyr Ser Ser Ser Pro Pro Pro Leu 
1               5                   10                  15      


Asp Asn Gly Ala Glu Asp Asp Asp Asp Asp Glu Phe Gly Glu Phe Gly 
            20                  25                  30          


Gly Phe Ser Glu Val Ser Pro Ser Gly Val Gly Phe Val Asp Phe Asp 
        35                  40                  45              


Thr Pro Asp Tyr Thr Arg Pro Lys Glu Glu Phe Val Pro Ser Asn His 
    50                  55                  60                  


Phe Met Pro Ile His Glu Phe Ser Glu Asn Val Asp Ser Leu Thr Ser 
65                  70                  75                  80  


Phe Lys Ser Ile Lys Asn Gly Asn Asp Lys Asp Ile Thr Ala Glu Leu 
                85                  90                  95      


Ser Ala Pro Val Lys Gly Gln Ser Asp Val Leu Leu Ser Thr Thr Ser 
            100                 105                 110         


Lys Glu Ile Ile Ser Ser Glu Met Leu Ala Thr Ser Ile Asp Gly Met 
        115                 120                 125             


Glu Arg Pro Gly Asn Leu Asn Lys Val Val Glu Gln Arg Gln Asn Val 
    130                 135                 140                 


Gly Thr Leu Glu Ser Phe Ser Pro Gly Asp Phe Arg Thr Asn Met Asn 
145                 150                 155                 160 


Val Val His Gln Asn Lys Gln Leu Glu Ser Cys Asn Gly Glu Lys Pro 
                165                 170                 175     


Pro Cys Leu Glu Ile Leu Thr Asn Gly Phe Ala Val Leu Glu Thr Val 
            180                 185                 190         


Asn Pro Gln Gly Thr Asp Asp Leu Asp Asn Val Ala Asp Ser Lys Gly 
        195                 200                 205             


Arg Lys Pro Leu Ser Thr His Ser Thr Glu Tyr Asn Leu Asp Ser Val 
    210                 215                 220                 


Pro Ser Pro Ala Glu Glu Phe Ala Asp Phe Ala Thr Phe Ser Lys Lys 
225                 230                 235                 240 


Glu Arg Ile Gln Leu Glu Glu Ile Glu Cys Ala Val Leu Asn Asp Arg 
                245                 250                 255     


Glu Ala Leu Thr Ile Arg Glu Asn Asn Lys Ile Asn Arg Val Asn Glu 
            260                 265                 270         


Leu Asn Ser Val Lys Glu Val Ala Leu Gly Arg Ser Leu Asp Asn Lys 
        275                 280                 285             


Gly Asp Thr Asp Gly Glu Asp Gln Val Cys Val Ser Glu Ile Ser Ile 
    290                 295                 300                 


Val Thr Asn Arg Gly Phe Ser Val Glu Lys Gln Gly Leu Pro Thr Leu 
305                 310                 315                 320 


Gln Gln Asp Glu Phe Leu Gln Ser Gly Val Gln Ser Lys Ala Trp Ser 
                325                 330                 335     


Leu Val Asp Ser Ala Asp Asn Ser Glu Ala Ile Arg Arg Glu Gln Cys 
            340                 345                 350         


Lys Thr Glu Glu Lys Leu Asp Leu Leu Thr Ser Lys Cys Ala His Leu 
        355                 360                 365             


Cys Met Asp Ser Val Lys Thr Ser Asp Asp Glu Val Gly Ser Pro Lys 
    370                 375                 380                 


Glu Glu Ser Arg Lys Phe Thr Asn Phe Gln Ser Pro Asn Ile Asp Pro 
385                 390                 395                 400 


Thr Glu Glu Asn Asp Leu Asp Asp Ser Leu Ser Val Lys Asn Gly Asp 
                405                 410                 415     


Ser Ser Asn Asp Phe Val Thr Cys Asn Asp Ile Asn Glu Asp Asp Phe 
            420                 425                 430         


Gly Asp Phe Gly Asp Phe Gly Ser Ala Ser Gly Ser Thr Pro Pro Phe 
        435                 440                 445             


Val Thr Gly Thr Gln Asp Ser Met Ser Asp Ala Thr Phe Glu Glu Ser 
    450                 455                 460                 


Ser Glu His Phe Pro His Phe Ser Glu Pro Gly Asp Asp Phe Gly Glu 
465                 470                 475                 480 


Phe Gly Asp Ile Asn Ala Val Ser Cys Gln Glu Glu Thr Ile Leu Thr 
                485                 490                 495     


Lys Ser Asp Leu Lys Gln Thr Ser Asp Asn Leu Ser Glu Glu Cys Gln 
            500                 505                 510         


Leu Ala Arg Lys Ser Ser Gly Thr Gly Thr Glu Pro Val Ala Lys Leu 
        515                 520                 525             


Lys Asn Gly Gln Glu Gly Glu Ile Gly His Phe Asp Ser Val Pro Asn 
    530                 535                 540                 


Ile Gln Asp Asp Cys Asn Gly Phe Gln Asp Ser Asp Asp Phe Ala Asp 
545                 550                 555                 560 


Phe Ser Ser Ala Gly Pro Ser Gln Val Val Asp Trp Asn Ala Phe Glu 
                565                 570                 575     


Asp Glu Gln Lys Asp Ser Cys Ser Trp Ala Ala Phe Gly Asp Gln Gln 
            580                 585                 590         


Ala Thr Glu Ser His His Arg Lys Glu Ala Trp Gln Ser His Arg Thr 
        595                 600                 605             


Asp Glu Asn Ile Asp Thr Pro Gly Thr Pro Lys Thr His Ser Val Pro 
    610                 615                 620                 


Ser Ala Thr Ser Lys Gly Ala Val Ala Ser Gly His Leu Gln Glu Ser 
625                 630                 635                 640 


Ala Thr Ser Val Gln Thr Ala Leu Leu Asn Arg Leu Glu Arg Ile Phe 
                645                 650                 655     


Glu Ala Cys Phe Pro Ser Ile Leu Val Pro Asp Ala Glu Glu Glu Val 
            660                 665                 670         


Thr Ser Leu Lys His Leu Leu Glu Thr Ser Thr Leu Pro Ile Lys Thr 
        675                 680                 685             


Arg Glu Ala Leu Pro Glu Ser Gly Glu Leu Leu Asp Val Trp Thr Glu 
    690                 695                 700                 


Leu Gln Asp Ile His Asp Ala His Gly Leu Arg Tyr Gln Trp Gly Gly 
705                 710                 715                 720 


Ser His Ser Asn Lys Lys Leu Leu Ser Ser Leu Gly Ile Asp Thr Arg 
                725                 730                 735     


Asn Ile Leu Phe Thr Gly Asn Lys Lys Gln Pro Val Ile Val Pro Met 
            740                 745                 750         


Tyr Ala Ala Gly Leu Gly Met Leu Glu Pro Thr Lys Glu Pro Leu Lys 
        755                 760                 765             


Pro Leu Ser Ala Ala Glu Lys Ile Ala Ser Ile Gly Gln Thr Ala Thr 
    770                 775                 780                 


Met Ser Pro Asp Met Asn Thr Cys Thr Ser Asp Gln Phe Gln Glu Ser 
785                 790                 795                 800 


Leu Pro Pro Val Gln Phe Asp Trp Ser Ser Ser Gly Leu Thr Asn Pro 
                805                 810                 815     


Leu Asp Ala Ser Gly Gly Ser Thr Leu Leu Asn Leu Asp Phe Phe Gly 
            820                 825                 830         


Pro Val Asp Asp Ser Ser Ser Ser Ser Ser Thr Thr Ile Pro Gly Val 
        835                 840                 845             


Asp Pro Glu Leu Tyr Glu Leu Thr Thr Ser Lys Leu Glu Ile Ser Thr 
    850                 855                 860                 


Ser Ser Leu Lys Val Thr Asp Ala Phe Ala Arg Leu Met Ser Thr Val 
865                 870                 875                 880 


Glu Lys Thr Ser Thr Ser Thr Arg Lys Pro Lys Arg Glu Glu His Leu 
                885                 890                 895     


Ser Glu Glu Ala Ile Lys Val Ile Ala Gly Leu Pro Asp Leu Thr Phe 
            900                 905                 910         


Met His Ala Lys Val Leu Met Phe Pro Ala Thr Leu Thr Pro Ser Thr 
        915                 920                 925             


Ser Ser Gln Glu Lys Ala Asp Gly 
    930                 935     


<210> 4772
<211> 909
<212> PRT
<213> Homo sapiens

<400> 4772
Met Glu Pro Asp Ile Ile Arg Met Tyr Ser Ser Ser Pro Pro Pro Leu 
1               5                   10                  15      


Asp Asn Gly Ala Glu Asp Asp Asp Asp Asp Glu Phe Gly Glu Phe Gly 
            20                  25                  30          


Gly Phe Ser Glu Val Ser Pro Ser Gly Val Gly Phe Val Asp Phe Asp 
        35                  40                  45              


Thr Pro Asp Tyr Thr Arg Pro Lys Glu Glu Phe Val Pro Ser Asn His 
    50                  55                  60                  


Phe Met Pro Ile His Glu Phe Ser Glu Asn Val Asp Ser Leu Thr Ser 
65                  70                  75                  80  


Phe Lys Ser Ile Lys Asn Gly Asn Asp Lys Asp Ile Thr Ala Glu Leu 
                85                  90                  95      


Ser Ala Pro Val Lys Gly Gln Ser Asp Val Leu Leu Ser Thr Thr Ser 
            100                 105                 110         


Lys Glu Ile Ile Ser Ser Glu Met Leu Ala Thr Ser Ile Asp Gly Met 
        115                 120                 125             


Glu Arg Pro Gly Asn Leu Asn Lys Val Val Glu Gln Arg Gln Asn Val 
    130                 135                 140                 


Gly Thr Leu Glu Ser Phe Ser Pro Gly Asp Phe Arg Thr Asn Met Asn 
145                 150                 155                 160 


Val Val His Gln Asn Lys Gln Leu Glu Ser Cys Asn Gly Glu Lys Pro 
                165                 170                 175     


Pro Cys Leu Glu Ile Leu Thr Asn Gly Phe Ala Val Leu Glu Thr Val 
            180                 185                 190         


Asn Pro Gln Gly Thr Asp Asp Leu Asp Asn Val Ala Asp Ser Lys Gly 
        195                 200                 205             


Arg Lys Pro Leu Ser Thr His Ser Thr Glu Tyr Asn Leu Asp Ser Val 
    210                 215                 220                 


Pro Ser Pro Ala Glu Glu Phe Ala Asp Phe Ala Thr Phe Ser Lys Lys 
225                 230                 235                 240 


Glu Arg Ile Gln Leu Glu Glu Ile Glu Cys Ala Val Leu Asn Asp Arg 
                245                 250                 255     


Glu Ala Leu Thr Ile Arg Glu Asn Asn Lys Ile Asn Arg Val Asn Glu 
            260                 265                 270         


Leu Asn Ser Val Lys Glu Val Ala Leu Gly Arg Ser Leu Asp Asn Lys 
        275                 280                 285             


Gly Asp Thr Asp Gly Glu Asp Gln Val Cys Val Ser Glu Ile Ser Ile 
    290                 295                 300                 


Val Thr Asn Arg Gly Phe Ser Val Glu Lys Gln Gly Leu Pro Thr Leu 
305                 310                 315                 320 


Gln Gln Asp Glu Phe Leu Gln Ser Gly Val Gln Ser Lys Ala Trp Ser 
                325                 330                 335     


Leu Val Asp Ser Ala Asp Asn Ser Glu Ala Ile Arg Arg Glu Gln Cys 
            340                 345                 350         


Lys Thr Glu Glu Lys Leu Asp Leu Leu Thr Ser Lys Cys Ala His Leu 
        355                 360                 365             


Cys Met Asp Ser Val Lys Thr Ser Asp Asp Glu Val Gly Ser Pro Lys 
    370                 375                 380                 


Glu Glu Ser Arg Lys Phe Thr Asn Phe Gln Ser Pro Asn Ile Asp Pro 
385                 390                 395                 400 


Thr Glu Glu Asn Asp Leu Asp Asp Ser Leu Ser Val Lys Asn Gly Asp 
                405                 410                 415     


Ser Ser Asn Asp Phe Val Thr Cys Asn Asp Ile Asn Glu Asp Asp Phe 
            420                 425                 430         


Gly Asp Phe Gly Asp Phe Gly Ser Ala Ser Gly Ser Thr Pro Pro Phe 
        435                 440                 445             


Val Thr Gly Thr Gln Asp Ser Met Ser Asp Ala Thr Phe Glu Glu Ser 
    450                 455                 460                 


Ser Glu His Phe Pro His Phe Ser Glu Pro Gly Asp Asp Phe Gly Glu 
465                 470                 475                 480 


Phe Gly Asp Ile Asn Ala Val Ser Cys Gln Glu Glu Thr Ile Leu Thr 
                485                 490                 495     


Lys Ser Asp Leu Lys Gln Thr Ser Asp Asn Leu Ser Glu Glu Cys Gln 
            500                 505                 510         


Leu Ala Arg Lys Ser Ser Gly Thr Gly Thr Glu Pro Val Ala Lys Leu 
        515                 520                 525             


Lys Asn Gly Gln Glu Gly Glu Ile Gly His Phe Asp Ser Val Pro Asn 
    530                 535                 540                 


Ile Gln Asp Asp Cys Asn Gly Phe Gln Asp Ser Asp Asp Phe Ala Asp 
545                 550                 555                 560 


Phe Ser Ser Ala Gly Pro Ser Gln Val Val Asp Trp Asn Ala Phe Glu 
                565                 570                 575     


Asp Glu Gln Lys Asp Ser Cys Ser Trp Ala Ala Phe Gly Asp Gln Gln 
            580                 585                 590         


Ala Thr Glu Ser His His Arg Lys Glu Ala Trp Gln Ser His Arg Thr 
        595                 600                 605             


Asp Glu Asn Ile Asp Thr Pro Gly Thr Pro Lys Thr His Ser Val Pro 
    610                 615                 620                 


Ser Ala Thr Ser Lys Gly Ala Val Ala Ser Gly His Leu Gln Glu Ser 
625                 630                 635                 640 


Ala Thr Ser Val Gln Thr Ala Leu Leu Asn Arg Leu Glu Arg Ile Phe 
                645                 650                 655     


Glu Ala Cys Phe Pro Ser Ile Leu Val Pro Asp Ala Glu Glu Glu Val 
            660                 665                 670         


Thr Ser Leu Lys His Leu Leu Glu Thr Ser Thr Leu Pro Ile Lys Thr 
        675                 680                 685             


Arg Glu Ala Leu Pro Glu Ser Gly Glu Leu Leu Asp Val Trp Thr Glu 
    690                 695                 700                 


Leu Gln Asp Ile His Asp Ala His Gly Leu Arg Tyr Gln Trp Gly Gly 
705                 710                 715                 720 


Ser His Ser Asn Lys Lys Leu Leu Ser Ser Leu Gly Ile Asp Thr Arg 
                725                 730                 735     


Asn Ile Leu Phe Thr Gly Asn Lys Lys Gln Pro Val Ile Val Pro Met 
            740                 745                 750         


Tyr Ala Ala Gly Leu Gly Met Leu Glu Pro Thr Lys Glu Pro Leu Lys 
        755                 760                 765             


Pro Leu Ser Ala Ala Glu Lys Ile Ala Ser Ile Gly Gln Thr Ala Thr 
    770                 775                 780                 


Met Ser Pro Asp Met Asn Thr Cys Thr Ser Asp Gln Phe Gln Glu Ser 
785                 790                 795                 800 


Leu Pro Pro Val Gln Phe Asp Trp Ser Ser Ser Gly Leu Thr Asn Pro 
                805                 810                 815     


Leu Asp Gly Val Asp Pro Glu Leu Tyr Glu Leu Thr Thr Ser Lys Leu 
            820                 825                 830         


Glu Ile Ser Thr Ser Ser Leu Lys Val Thr Asp Ala Phe Ala Arg Leu 
        835                 840                 845             


Met Ser Thr Val Glu Lys Thr Ser Thr Ser Thr Ser Arg Lys Pro Lys 
    850                 855                 860                 


Arg Glu Glu His Leu Ser Glu Glu Ala Ile Lys Val Ile Ala Gly Leu 
865                 870                 875                 880 


Pro Asp Leu Thr Phe Met His Ala Lys Val Leu Met Phe Pro Ala Thr 
                885                 890                 895     


Leu Thr Pro Ser Thr Ser Ser Gln Glu Lys Ala Asp Gly 
            900                 905                 


<210> 4773
<211> 101
<212> PRT
<213> Homo sapiens

<400> 4773
Met Val Cys Glu Lys Cys Glu Lys Lys Leu Gly Thr Val Ile Thr Pro 
1               5                   10                  15      


Asp Thr Trp Lys Asp Gly Ala Arg Asn Thr Thr Glu Ser Gly Gly Arg 
            20                  25                  30          


Lys Leu Asn Glu Asn Lys Ala Leu Thr Ser Lys Lys Ala Arg Phe Asp 
        35                  40                  45              


Pro Tyr Gly Lys Asn Lys Phe Ser Thr Cys Arg Ile Cys Lys Ser Ser 
    50                  55                  60                  


Val His Gln Pro Gly Ser His Tyr Cys Gln Gly Cys Ala Tyr Lys Lys 
65                  70                  75                  80  


Gly Ile Cys Ala Met Cys Gly Lys Lys Val Leu Asp Thr Lys Asn Tyr 
                85                  90                  95      


Lys Gln Thr Ser Val 
            100     


<210> 4774
<211> 488
<212> PRT
<213> Homo sapiens

<400> 4774
Met Asn Phe Thr Pro Thr His Thr Pro Val Cys Arg Lys Arg Thr Val 
1               5                   10                  15      


Val Ser Lys Arg Gly Val Ala Val Ser Gly Pro Thr Lys Arg Arg Gly 
            20                  25                  30          


Met Ala Asp Ser Leu Glu Ser Thr Pro Leu Pro Ser Pro Glu Asp Arg 
        35                  40                  45              


Leu Ala Lys Leu His Pro Ser Lys Glu Leu Leu Glu Tyr Tyr Gln Lys 
    50                  55                  60                  


Lys Met Ala Glu Cys Glu Ala Glu Asn Glu Asp Leu Leu Lys Lys Leu 
65                  70                  75                  80  


Glu Leu Tyr Lys Glu Ala Cys Glu Gly Gln His Lys Leu Glu Cys Asp 
                85                  90                  95      


Leu Gln Gln Arg Glu Glu Glu Ile Ala Glu Leu Gln Lys Ala Leu Ser 
            100                 105                 110         


Asp Met Gln Val Cys Leu Phe Gln Glu Arg Glu His Val Leu Arg Leu 
        115                 120                 125             


Tyr Ser Glu Asn Asp Arg Leu Arg Ile Arg Glu Leu Glu Asp Lys Lys 
    130                 135                 140                 


Lys Ile Gln Asn Leu Leu Ala Leu Val Gly Thr Asp Ala Gly Glu Val 
145                 150                 155                 160 


Thr Tyr Phe Cys Lys Glu Pro Pro His Lys Val Thr Ile Leu Gln Lys 
                165                 170                 175     


Thr Ile Gln Ala Val Gly Glu Cys Glu Gln Ser Glu Ser Ser Ala Phe 
            180                 185                 190         


Lys Ala Asp Pro Lys Ile Ser Lys Arg Arg Pro Ser Arg Glu Arg Lys 
        195                 200                 205             


Glu Ser Ser Glu His Tyr Gln Arg Asp Ile Gln Thr Leu Ile Leu Gln 
    210                 215                 220                 


Val Glu Ala Leu Gln Ala Gln Leu Gly Glu Gln Thr Lys Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Ile Glu Gly Leu Ile Glu Asp Arg Arg Ile His Leu Glu Glu 
                245                 250                 255     


Ile Gln Val Gln His Gln Arg Asn Gln Asn Lys Ile Lys Glu Leu Thr 
            260                 265                 270         


Lys Asn Leu His His Thr Gln Glu Leu Leu Tyr Glu Ser Thr Lys Asp 
        275                 280                 285             


Phe Leu Gln Leu Arg Ser Glu Asn Gln Asn Lys Glu Lys Ser Trp Met 
    290                 295                 300                 


Leu Glu Lys Asp Asn Leu Met Ser Lys Ile Lys Gln Tyr Arg Val Gln 
305                 310                 315                 320 


Cys Lys Lys Lys Glu Asp Lys Ile Gly Lys Val Leu Pro Val Met His 
                325                 330                 335     


Glu Ser His His Ala Gln Ser Glu Tyr Ile Lys Ser Leu Lys Asp Lys 
            340                 345                 350         


Leu Val Gln Glu Lys Lys Leu Ser Asn Met Tyr Gln Glu Gln Cys Ile 
        355                 360                 365             


Ser Leu Glu Glu Glu Leu Ala Arg Ile Arg Glu Glu Glu Gly Met Arg 
    370                 375                 380                 


Arg Glu Ile Phe Lys Asp Arg Thr Asn Lys Met Gly Lys Arg Leu Gln 
385                 390                 395                 400 


Ile Met Thr Lys Arg Tyr Glu Ala Leu Glu Arg Arg Arg Ile Leu Glu 
                405                 410                 415     


Val Glu Gly Phe Lys Thr Asp Ile Lys Val Leu Arg Gln Lys Leu Lys 
            420                 425                 430         


Asp Leu Glu Gln Met Leu Tyr Lys Ala Thr Val Asn Ala Arg Ala Asn 
        435                 440                 445             


Gln Asp Leu Ala Leu Leu Cys Glu Val Arg Asp Ser Asn Arg Arg Ala 
    450                 455                 460                 


His Lys Ile Gln Gly Glu Leu Lys Asn Leu Lys Ser Lys Val Phe Gly 
465                 470                 475                 480 


Leu Glu Asn Glu Leu Arg Leu Cys 
                485             


<210> 4775
<211> 85
<212> PRT
<213> Homo sapiens

<400> 4775
Met Ser Lys Val Ser Phe Lys Ile Thr Leu Thr Ser Asp Pro Arg Leu 
1               5                   10                  15      


Pro Tyr Lys Val Leu Ser Val Pro Glu Ser Thr Pro Phe Thr Ala Val 
            20                  25                  30          


Leu Lys Phe Ala Ala Glu Glu Phe Lys Val Pro Ala Ala Thr Ser Ala 
        35                  40                  45              


Ile Ile Thr Asn Asp Gly Ile Gly Ile Asn Pro Ala Gln Thr Ala Gly 
    50                  55                  60                  


Asn Val Phe Leu Lys His Gly Ser Glu Leu Arg Ile Ile Pro Arg Asp 
65                  70                  75                  80  


Arg Val Gly Ser Cys 
                85  


<210> 4776
<211> 194
<212> PRT
<213> Homo sapiens

<400> 4776
Met Asp Glu Asp Gly Leu Pro Leu Met Gly Ser Gly Ile Asp Leu Thr 
1               5                   10                  15      


Lys Val Pro Ala Ile Gln Gln Lys Arg Thr Val Ala Phe Leu Asn Gln 
            20                  25                  30          


Phe Val Val His Thr Val Gln Phe Leu Asn Arg Phe Ser Thr Val Cys 
        35                  40                  45              


Glu Glu Lys Leu Ala Asp Leu Ser Leu Arg Ile Gln Gln Ile Glu Thr 
    50                  55                  60                  


Thr Leu Asn Ile Leu Asp Ala Lys Leu Ser Ser Ile Pro Gly Leu Asp 
65                  70                  75                  80  


Asp Val Thr Val Glu Val Ser Pro Leu Asn Val Thr Ser Val Thr Asn 
                85                  90                  95      


Gly Ala His Pro Glu Ala Thr Ser Glu Gln Pro Gln Gln Asn Ser Thr 
            100                 105                 110         


Gln Asp Ser Gly Leu Gln Glu Ser Glu Val Ser Ala Glu Asn Ile Leu 
        115                 120                 125             


Thr Val Ala Lys Asp Pro Arg Tyr Ala Arg Tyr Leu Lys Met Val Gln 
    130                 135                 140                 


Val Gly Val Pro Val Met Ala Ile Arg Asn Lys Met Ile Ser Glu Gly 
145                 150                 155                 160 


Leu Asp Pro Asp Leu Leu Glu Arg Pro Asp Ala Pro Val Pro Asp Gly 
                165                 170                 175     


Glu Ser Glu Lys Thr Val Glu Glu Ser Ser Asp Ser Glu Ser Ser Phe 
            180                 185                 190         


Ser Asp 
        


<210> 4777
<211> 741
<212> PRT
<213> Homo sapiens

<400> 4777
Met Gly Pro Pro Gly Pro Ala Leu Pro Ala Thr Met Asn Asn Ser Ser 
1               5                   10                  15      


Ser Glu Thr Arg Gly His Pro His Ser Ala Ser Ser Pro Ser Glu Arg 
            20                  25                  30          


Val Phe Pro Met Pro Leu Pro Arg Lys Ala Pro Leu Asn Ile Pro Gly 
        35                  40                  45              


Thr Pro Val Leu Glu Asp Phe Pro Gln Asn Asp Asp Glu Lys Glu Arg 
    50                  55                  60                  


Leu Gln Arg Arg Arg Ser Arg Val Phe Asp Leu Gln Phe Ser Thr Asp 
65                  70                  75                  80  


Ser Pro Arg Leu Leu Ala Ser Pro Ser Ser Arg Ser Ile Asp Ile Ser 
                85                  90                  95      


Ala Thr Ile Pro Lys Phe Thr Asn Thr Gln Ile Thr Glu His Tyr Ser 
            100                 105                 110         


Thr Cys Ile Lys Leu Ser Thr Glu Asn Lys Ile Thr Thr Lys Asn Ala 
        115                 120                 125             


Phe Gly Leu His Leu Ile Asp Phe Met Ser Glu Ile Leu Lys Gln Lys 
    130                 135                 140                 


Asp Thr Glu Pro Thr Asn Phe Lys Val Ala Ala Gly Thr Leu Asp Ala 
145                 150                 155                 160 


Ser Thr Lys Ile Tyr Ala Val Arg Val Asp Ala Val His Ala Asp Val 
                165                 170                 175     


Tyr Arg Val Leu Gly Gly Leu Gly Lys Asp Ala Pro Ser Leu Glu Glu 
            180                 185                 190         


Val Glu Gly His Val Ala Asp Gly Ser Ala Thr Glu Met Gly Thr Thr 
        195                 200                 205             


Lys Lys Ala Val Lys Pro Lys Lys Lys His Leu His Arg Thr Ile Glu 
    210                 215                 220                 


Gln Asn Ile Asn Asn Leu Asn Val Ser Glu Ala Asp Arg Lys Cys Glu 
225                 230                 235                 240 


Ile Asp Pro Met Phe Gln Lys Thr Ala Ala Ser Phe Asp Glu Cys Ser 
                245                 250                 255     


Thr Ala Gly Val Phe Leu Ser Thr Leu His Cys Gln Asp Tyr Arg Ser 
            260                 265                 270         


Glu Leu Leu Phe Pro Ser Asp Val Gln Thr Leu Ser Thr Gly Glu Pro 
        275                 280                 285             


Leu Glu Leu Pro Glu Leu Gly Cys Val Glu Met Thr Asp Leu Lys Ala 
    290                 295                 300                 


Pro Leu Gln Gln Cys Ala Glu Asp Arg Gln Ile Cys Pro Ser Leu Ala 
305                 310                 315                 320 


Gly Phe Gln Phe Thr Gln Trp Asp Ser Glu Thr His Asn Glu Ser Val 
                325                 330                 335     


Ser Ala Leu Val Asp Lys Phe Lys Lys Asn Asp Gln Val Phe Asp Ile 
            340                 345                 350         


Asn Ala Glu Val Asp Glu Ser Asp Cys Gly Asp Phe Pro Asp Gly Ser 
        355                 360                 365             


Leu Gly Asp Asp Phe Asp Ala Asn Asp Glu Pro Asp His Thr Ala Val 
    370                 375                 380                 


Gly Asp His Glu Glu Phe Arg Ser Trp Lys Glu Pro Cys Gln Val Gln 
385                 390                 395                 400 


Ser Cys Gln Glu Glu Met Ile Ser Leu Gly Asp Gly Asp Ile Arg Thr 
                405                 410                 415     


Met Cys Pro Leu Leu Ser Met Lys Pro Gly Glu Tyr Ser Tyr Phe Ser 
            420                 425                 430         


Pro Arg Thr Met Ser Met Trp Ala Gly Pro Asp His Trp Arg Phe Arg 
        435                 440                 445             


Pro Arg Arg Lys Gln Asp Ala Pro Ser Gln Ser Glu Asn Lys Lys Lys 
    450                 455                 460                 


Ser Thr Lys Lys Asp Phe Glu Ile Asp Phe Glu Asp Asp Ile Asp Phe 
465                 470                 475                 480 


Asp Val Tyr Phe Arg Lys Thr Lys Ala Ala Thr Ile Leu Thr Lys Ser 
                485                 490                 495     


Thr Leu Glu Asn Gln Asn Trp Arg Ala Thr Thr Leu Pro Thr Asp Phe 
            500                 505                 510         


Asn Tyr Asn Val Asp Thr Leu Val Gln Leu His Leu Lys Pro Gly Thr 
        515                 520                 525             


Arg Leu Leu Lys Met Ala Gln Gly His Arg Val Glu Thr Glu His Tyr 
    530                 535                 540                 


Glu Glu Ile Glu Asp Tyr Asp Tyr Asn Asn Pro Asn Asp Thr Ser Asn 
545                 550                 555                 560 


Phe Cys Pro Gly Leu Gln Ala Ala Asp Ser Asp Asp Glu Asp Leu Asp 
                565                 570                 575     


Asp Leu Phe Val Gly Pro Val Gly Asn Ser Asp Leu Ser Pro Tyr Pro 
            580                 585                 590         


Cys His Pro Pro Lys Thr Ala Gln Gln Asn Gly Asp Thr Pro Glu Ala 
        595                 600                 605             


Gln Gly Leu Asp Ile Thr Thr Tyr Gly Glu Ser Asn Leu Val Ala Glu 
    610                 615                 620                 


Pro Gln Lys Val Asn Lys Ile Glu Ile His Tyr Ala Lys Thr Ala Lys 
625                 630                 635                 640 


Lys Met Asp Met Lys Lys Leu Lys Gln Ser Met Trp Ser Leu Leu Thr 
                645                 650                 655     


Ala Leu Ser Gly Lys Glu Ala Asp Ala Glu Ala Asn His Arg Glu Ala 
            660                 665                 670         


Gly Lys Glu Ala Ala Leu Ala Glu Val Ala Asp Glu Lys Met Leu Ser 
        675                 680                 685             


Gly Leu Thr Lys Asp Leu Gln Arg Ser Leu Pro Pro Val Met Ala Gln 
    690                 695                 700                 


Asn Leu Ser Ile Pro Leu Ala Phe Ala Cys Leu Leu His Leu Ala Asn 
705                 710                 715                 720 


Glu Lys Asn Leu Lys Leu Glu Gly Thr Glu Asp Leu Ser Asp Val Leu 
                725                 730                 735     


Val Arg Gln Gly Asp 
            740     


<210> 4778
<211> 169
<212> PRT
<213> Homo sapiens

<400> 4778
Met Lys Gly Ser Arg Ile Glu Leu Gly Asp Val Thr Pro His Asn Ile 
1               5                   10                  15      


Lys Gln Leu Lys Arg Leu Asn Gln Val Ile Phe Pro Val Ser Tyr Asn 
            20                  25                  30          


Asp Lys Phe Tyr Lys Asp Val Leu Glu Val Gly Glu Leu Ala Lys Leu 
        35                  40                  45              


Ala Tyr Phe Asn Asp Ile Ala Val Gly Ala Val Cys Cys Arg Val Asp 
    50                  55                  60                  


His Ser Gln Asn Gln Lys Arg Leu Tyr Ile Met Thr Leu Gly Cys Leu 
65                  70                  75                  80  


Ala Pro Tyr Arg Arg Leu Gly Ile Gly Thr Lys Met Leu Asn His Val 
                85                  90                  95      


Leu Asn Ile Cys Glu Lys Asp Gly Thr Phe Asp Asn Ile Tyr Leu His 
            100                 105                 110         


Val Gln Ile Ser Asn Glu Ser Ala Ile Asp Phe Tyr Arg Lys Phe Gly 
        115                 120                 125             


Phe Glu Ile Ile Glu Thr Lys Lys Asn Tyr Tyr Lys Arg Ile Glu Pro 
    130                 135                 140                 


Ala Asp Ala His Val Leu Gln Lys Asn Leu Lys Val Pro Ser Gly Gln 
145                 150                 155                 160 


Asn Ala Asp Val Gln Lys Thr Asp Asn 
                165                 


<210> 4779
<211> 414
<212> PRT
<213> Homo sapiens

<400> 4779
Met Ala Ala Ala Pro Pro Ser Tyr Cys Phe Val Ala Phe Pro Pro Arg 
1               5                   10                  15      


Ala Lys Asp Gly Leu Val Val Phe Gly Lys Asn Ser Ala Arg Pro Arg 
            20                  25                  30          


Asp Glu Val Gln Glu Val Val Tyr Phe Ser Ala Ala Asp His Glu Pro 
        35                  40                  45              


Glu Ser Lys Val Glu Cys Thr Tyr Ile Ser Ile Asp Gln Val Pro Arg 
    50                  55                  60                  


Thr Tyr Ala Ile Met Ile Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Ala Asn Glu Ala Ile Asn 
                85                  90                  95      


Thr Arg Glu Pro Ala Ala Glu Ile Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Gly Glu Thr Ala Lys Glu Ala Leu Asp 
        115                 120                 125             


Val Ile Val Ser Leu Leu Glu Glu His Gly Gln Gly Gly Asn Tyr Phe 
    130                 135                 140                 


Glu Asp Ala Asn Ser Cys His Ser Phe Gln Ser Ala Tyr Leu Ile Val 
145                 150                 155                 160 


Asp Arg Asp Glu Ala Trp Val Leu Glu Thr Ile Gly Lys Tyr Trp Ala 
                165                 170                 175     


Ala Glu Lys Val Thr Glu Gly Val Arg Cys Ile Cys Ser Gln Leu Ser 
            180                 185                 190         


Leu Thr Thr Lys Met Asp Ala Glu His Pro Glu Leu Arg Ser Tyr Ala 
        195                 200                 205             


Gln Ser Gln Gly Trp Trp Thr Gly Glu Gly Glu Phe Asn Phe Ser Glu 
    210                 215                 220                 


Val Phe Ser Pro Val Glu Asp His Leu Asp Cys Gly Ala Gly Lys Asp 
225                 230                 235                 240 


Ser Leu Glu Lys Gln Glu Glu Ser Ile Thr Val Gln Thr Met Met Asn 
                245                 250                 255     


Thr Leu Arg Asp Lys Ala Ser Gly Val Cys Ile Asp Ser Glu Phe Phe 
            260                 265                 270         


Leu Thr Thr Ala Ser Gly Val Ser Val Leu Pro Gln Asn Arg Ser Ser 
        275                 280                 285             


Pro Cys Ile His Tyr Phe Thr Gly Thr Pro Asp Pro Ser Arg Ser Ile 
    290                 295                 300                 


Phe Lys Pro Phe Ile Phe Val Asp Asp Val Lys Leu Val Pro Lys Thr 
305                 310                 315                 320 


Gln Ser Pro Cys Phe Gly Asp Asp Asp Pro Ala Lys Lys Glu Pro Arg 
                325                 330                 335     


Phe Gln Glu Lys Pro Asp Arg Arg His Glu Leu Tyr Lys Ala His Glu 
            340                 345                 350         


Trp Ala Arg Ala Ile Ile Glu Ser Asp Gln Glu Gln Gly Arg Lys Leu 
        355                 360                 365             


Arg Ser Thr Met Leu Glu Leu Glu Lys Gln Gly Leu Glu Ala Met Glu 
    370                 375                 380                 


Glu Ile Leu Thr Ser Ser Glu Pro Leu Asp Pro Ala Glu Val Gly Asp 
385                 390                 395                 400 


Leu Phe Tyr Asp Cys Val Asp Thr Glu Ile Lys Phe Phe Lys 
                405                 410                 


<210> 4780
<211> 676
<212> PRT
<213> Homo sapiens

<400> 4780
Met Ser Asp Gln Ile Lys Phe Ile Met Asp Ser Leu Asn Lys Glu Pro 
1               5                   10                  15      


Phe Arg Lys Asn Tyr Asn Leu Ile Thr Phe Asp Ser Leu Glu Pro Met 
            20                  25                  30          


Gln Leu Leu Gln Val Leu Ser Asp Val Leu Ala Glu Ile Asp Pro Lys 
        35                  40                  45              


Gln Leu Val Asp Ile Arg Glu Glu Met Pro Glu Gln Thr Ala Lys Arg 
    50                  55                  60                  


Met Leu Ser Leu Leu Gly Ile Leu Lys Tyr Lys Pro Ser Gly Asn Ala 
65                  70                  75                  80  


Thr Asp Met Ser Thr Phe Arg Gln Gly Leu Val Ile Gly Ser Lys Pro 
                85                  90                  95      


Val Ile Tyr Pro Val Leu His Trp Leu Leu Gln Arg Thr Asn Glu Leu 
            100                 105                 110         


Lys Lys Arg Ala Tyr Leu Ala Arg Phe Leu Ile Lys Leu Glu Val Pro 
        115                 120                 125             


Ser Glu Phe Leu Gln Asp Glu Thr Val Ala Asp Thr Asn Lys Gln Tyr 
    130                 135                 140                 


Glu Glu Leu Met Glu Ala Phe Lys Thr Leu His Lys Glu Tyr Glu Gln 
145                 150                 155                 160 


Leu Lys Ile Ser Gly Phe Ser Thr Ala Glu Ile Arg Lys Asp Ile Ser 
                165                 170                 175     


Ala Met Glu Glu Glu Lys Asp Gln Leu Ile Lys Arg Val Glu His Leu 
            180                 185                 190         


Lys Lys Arg Val Glu Thr Ala Gln Asn His Gln Trp Met Leu Lys Ile 
        195                 200                 205             


Ala Arg Gln Leu Arg Val Glu Lys Glu Arg Glu Glu Tyr Leu Ala Gln 
    210                 215                 220                 


Gln Lys Gln Glu Gln Lys Asn Gln Leu Phe His Ala Val Gln Arg Leu 
225                 230                 235                 240 


Gln Arg Val Gln Asn Gln Leu Lys Ser Met Arg Gln Ala Ala Ala Asp 
                245                 250                 255     


Ala Lys Pro Glu Ser Leu Met Lys Arg Leu Glu Glu Glu Ile Lys Phe 
            260                 265                 270         


Asn Leu Tyr Met Val Thr Glu Lys Phe Pro Lys Glu Leu Glu Asn Lys 
        275                 280                 285             


Lys Lys Glu Leu His Phe Leu Gln Lys Val Val Ser Glu Pro Ala Met 
    290                 295                 300                 


Gly His Ser Asp Leu Leu Glu Leu Glu Ser Lys Ile Asn Glu Ile Asn 
305                 310                 315                 320 


Thr Glu Ile Asn Gln Leu Ile Glu Lys Lys Met Met Arg Asn Glu Pro 
                325                 330                 335     


Ile Glu Gly Lys Leu Ser Leu Tyr Arg Gln Gln Ala Ser Ile Ile Ser 
            340                 345                 350         


Arg Lys Lys Glu Ala Lys Ala Glu Glu Leu Gln Glu Ala Lys Glu Lys 
        355                 360                 365             


Leu Ala Ser Leu Glu Arg Glu Ala Ser Val Lys Arg Asn Gln Thr Arg 
    370                 375                 380                 


Glu Phe Asp Gly Thr Glu Val Leu Lys Gly Asp Glu Phe Lys Arg Tyr 
385                 390                 395                 400 


Val Asn Lys Leu Arg Ser Lys Ser Thr Val Phe Lys Lys Lys His Gln 
                405                 410                 415     


Ile Ile Ala Glu Leu Lys Ala Glu Phe Gly Leu Leu Gln Arg Thr Glu 
            420                 425                 430         


Glu Leu Leu Lys Gln Arg His Glu Asn Ile Gln Gln Gln Leu Gln Thr 
        435                 440                 445             


Met Glu Glu Lys Lys Gly Ile Ser Gly Tyr Ser Tyr Thr Gln Glu Glu 
    450                 455                 460                 


Leu Glu Arg Val Ser Ala Leu Lys Ser Glu Val Asp Glu Met Lys Gly 
465                 470                 475                 480 


Arg Thr Leu Asp Asp Met Ser Glu Met Val Lys Lys Leu Tyr Ser Leu 
                485                 490                 495     


Val Ser Glu Lys Lys Ser Ala Leu Ala Ser Val Ile Lys Glu Leu Arg 
            500                 505                 510         


Gln Leu Arg Gln Lys Tyr Gln Glu Leu Thr Gln Glu Cys Asp Glu Lys 
        515                 520                 525             


Lys Ser Gln Tyr Asp Ser Cys Ala Ala Gly Leu Glu Ser Asn Arg Ser 
    530                 535                 540                 


Lys Leu Glu Gln Glu Val Arg Arg Leu Arg Glu Glu Cys Leu Gln Glu 
545                 550                 555                 560 


Glu Ser Arg Tyr His Tyr Thr Asn Cys Met Ile Lys Asn Leu Glu Val 
                565                 570                 575     


Gln Leu Arg Arg Ala Thr Asp Glu Met Lys Ala Tyr Ile Ser Ser Asp 
            580                 585                 590         


Gln Gln Glu Lys Arg Lys Ala Ile Arg Glu Gln Tyr Thr Lys Asn Thr 
        595                 600                 605             


Ala Glu Gln Glu Asn Leu Gly Lys Lys Leu Arg Glu Lys Gln Lys Val 
    610                 615                 620                 


Ile Arg Glu Ser His Gly Pro Asn Met Lys Gln Ala Lys Met Trp Arg 
625                 630                 635                 640 


Asp Leu Glu Gln Leu Met Glu Cys Lys Lys Gln Cys Phe Leu Lys Gln 
                645                 650                 655     


Gln Ser Gln Thr Ser Ile Gly Gln Val Ile Gln Glu Gly Gly Glu Asp 
            660                 665                 670         


Arg Leu Ile Leu 
        675     


<210> 4781
<211> 315
<212> PRT
<213> Homo sapiens

<400> 4781
Met Ala Phe Pro Glu Pro Lys Pro Arg Pro Pro Glu Leu Pro Gln Lys 
1               5                   10                  15      


Arg Leu Lys Thr Leu Asp Cys Gly Gln Gly Ala Val Arg Ala Val Arg 
            20                  25                  30          


Phe Asn Val Asp Gly Asn Tyr Cys Leu Thr Cys Gly Ser Asp Lys Thr 
        35                  40                  45              


Leu Lys Leu Trp Asn Pro Leu Arg Gly Thr Leu Leu Arg Thr Tyr Ser 
    50                  55                  60                  


Gly His Gly Tyr Glu Val Leu Asp Ala Ala Gly Ser Phe Asp Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Ser Gly Gly Gly Asp Lys Ala Val Val Leu Trp Asp Val 
                85                  90                  95      


Ala Ser Gly Gln Val Val Arg Lys Phe Arg Gly His Ala Gly Lys Val 
            100                 105                 110         


Asn Thr Val Gln Phe Asn Glu Glu Ala Thr Val Ile Leu Ser Gly Ser 
        115                 120                 125             


Ile Asp Ser Ser Ile Arg Cys Trp Asp Cys Arg Ser Arg Arg Pro Glu 
    130                 135                 140                 


Pro Val Gln Thr Leu Asp Glu Ala Arg Asp Gly Val Ser Ser Val Lys 
145                 150                 155                 160 


Val Ser Asp His Glu Ile Leu Ala Gly Ser Val Asp Gly Arg Val Arg 
                165                 170                 175     


Arg Tyr Asp Leu Arg Met Gly Gln Leu Phe Ser Asp Tyr Val Gly Ser 
            180                 185                 190         


Pro Ile Thr Cys Thr Cys Phe Ser Arg Asp Gly Gln Cys Thr Leu Val 
        195                 200                 205             


Ser Ser Leu Asp Ser Thr Leu Arg Leu Leu Asp Lys Asp Thr Gly Glu 
    210                 215                 220                 


Leu Leu Gly Glu Tyr Lys Gly His Lys Asn Gln Glu Tyr Lys Leu Asp 
225                 230                 235                 240 


Cys Cys Leu Ser Glu Arg Asp Thr His Val Val Ser Cys Ser Glu Asp 
                245                 250                 255     


Gly Lys Val Phe Phe Trp Asp Leu Val Glu Gly Ala Leu Ala Leu Ala 
            260                 265                 270         


Leu Pro Val Gly Ser Gly Val Val Gln Ser Leu Ala Tyr His Pro Thr 
        275                 280                 285             


Glu Pro Cys Leu Leu Thr Ala Met Gly Gly Ser Val Gln Cys Trp Arg 
    290                 295                 300                 


Glu Glu Ala Tyr Glu Ala Glu Asp Gly Ala Gly 
305                 310                 315 


<210> 4782
<211> 600
<212> PRT
<213> Homo sapiens

<400> 4782
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met Glu Cys Phe Leu Gln Tyr Val Tyr Thr Gly Lys 
        115                 120                 125             


Val Lys Ile Thr Thr Glu Asn Val Gln Tyr Leu Phe Glu Thr Ser Ser 
    130                 135                 140                 


Leu Phe Gln Ile Ser Val Leu Arg Asp Ala Cys Ala Lys Phe Leu Glu 
145                 150                 155                 160 


Glu Gln Leu Asp Pro Cys Asn Cys Leu Gly Ile Gln Arg Phe Ala Asp 
                165                 170                 175     


Thr His Ser Leu Lys Thr Leu Phe Thr Lys Cys Lys Asn Phe Ala Leu 
            180                 185                 190         


Gln Thr Phe Glu Asp Val Ser Gln His Glu Glu Phe Leu Glu Leu Asp 
        195                 200                 205             


Lys Asp Glu Leu Ile Asp Tyr Ile Cys Ser Asp Glu Leu Val Ile Gly 
    210                 215                 220                 


Lys Glu Glu Met Val Phe Glu Ala Val Met Arg Trp Val Tyr Arg Ala 
225                 230                 235                 240 


Val Asp Leu Arg Arg Pro Leu Leu His Glu Leu Leu Thr His Val Arg 
                245                 250                 255     


Leu Pro Leu Leu His Pro Asn Tyr Phe Val Gln Thr Val Glu Val Asp 
            260                 265                 270         


Gln Leu Ile Gln Asn Ser Pro Glu Cys Tyr Gln Leu Leu His Glu Ala 
        275                 280                 285             


Arg Arg Tyr His Ile Leu Gly Asn Glu Met Met Ser Pro Arg Thr Arg 
    290                 295                 300                 


Pro Arg Arg Ser Thr Gly Tyr Ser Glu Val Ile Val Val Val Gly Gly 
305                 310                 315                 320 


Cys Glu Arg Val Gly Gly Phe Asn Leu Pro Tyr Thr Glu Cys Tyr Asp 
                325                 330                 335     


Pro Val Thr Gly Glu Trp Lys Ser Leu Ala Lys Leu Pro Glu Phe Thr 
            340                 345                 350         


Lys Ser Glu Tyr Ala Val Cys Ala Leu Arg Asn Asp Ile Leu Val Ser 
        355                 360                 365             


Gly Gly Arg Ile Asn Ser Arg Asp Val Trp Ile Tyr Asn Ser Gln Leu 
    370                 375                 380                 


Asn Ile Trp Ile Arg Val Ala Ser Leu Asn Lys Gly Arg Trp Arg His 
385                 390                 395                 400 


Lys Met Ala Val Leu Leu Gly Lys Val Tyr Val Val Gly Gly Tyr Asp 
                405                 410                 415     


Gly Gln Asn Arg Leu Ser Ser Val Glu Cys Tyr Asp Ser Phe Ser Asn 
            420                 425                 430         


Arg Trp Thr Glu Val Ala Pro Leu Lys Glu Ala Val Ser Ser Pro Ala 
        435                 440                 445             


Val Thr Ser Cys Val Gly Lys Leu Phe Val Ile Gly Gly Gly Pro Asp 
    450                 455                 460                 


Asp Asn Thr Cys Ser Asp Lys Val Gln Ser Tyr Asp Pro Glu Thr Asn 
465                 470                 475                 480 


Ser Trp Leu Leu Arg Ala Ala Ile Pro Ile Ala Lys Arg Cys Ile Thr 
                485                 490                 495     


Ala Val Ser Leu Asn Asn Leu Ile Tyr Val Ala Gly Gly Leu Thr Lys 
            500                 505                 510         


Ala Ile Tyr Cys Tyr Asp Pro Val Glu Asp Tyr Trp Met His Val Gln 
        515                 520                 525             


Asn Thr Phe Ser Arg Gln Glu Asn Cys Gly Met Ser Val Cys Asn Gly 
    530                 535                 540                 


Lys Ile Tyr Ile Leu Gly Gly Arg Arg Glu Asn Gly Glu Ala Thr Asp 
545                 550                 555                 560 


Thr Ile Leu Cys Tyr Asp Pro Ala Thr Ser Ile Ile Thr Gly Val Ala 
                565                 570                 575     


Ala Met Pro Arg Pro Val Ser Tyr His Gly Cys Val Thr Ile His Arg 
            580                 585                 590         


Tyr Asn Glu Lys Cys Phe Lys Leu 
        595                 600 


<210> 4783
<211> 269
<212> PRT
<213> Homo sapiens

<400> 4783
Met Asn Gln Glu Asp Leu Asp Pro Asp Ser Thr Thr Asp Val Gly Asp 
1               5                   10                  15      


Val Thr Asn Thr Glu Glu Glu Leu Ile Arg Glu Cys Glu Glu Met Trp 
            20                  25                  30          


Lys Asp Met Glu Glu Cys Gln Asn Lys Leu Ser Leu Ile Gly Thr Glu 
        35                  40                  45              


Thr Leu Thr Asp Ser Asn Ala Gln Leu Ser Leu Leu Ile Met Gln Val 
    50                  55                  60                  


Lys Cys Leu Thr Ala Glu Leu Ser Gln Trp Gln Lys Lys Thr Pro Glu 
65                  70                  75                  80  


Thr Ile Pro Leu Thr Glu Asp Val Leu Ile Thr Leu Gly Lys Glu Glu 
                85                  90                  95      


Phe Gln Lys Leu Arg Gln Asp Leu Glu Met Val Leu Ser Thr Lys Glu 
            100                 105                 110         


Ser Lys Asn Glu Lys Leu Lys Glu Asp Leu Glu Arg Glu Gln Arg Trp 
        115                 120                 125             


Leu Asp Glu Gln Gln Gln Ile Met Glu Ser Leu Asn Val Leu His Ser 
    130                 135                 140                 


Glu Leu Lys Asn Lys Val Glu Thr Phe Ser Glu Ser Arg Ile Phe Asn 
145                 150                 155                 160 


Glu Leu Lys Thr Lys Met Leu Asn Ile Lys Glu Tyr Lys Glu Lys Leu 
                165                 170                 175     


Leu Ser Thr Leu Gly Glu Phe Leu Glu Asp His Phe Pro Leu Pro Asp 
            180                 185                 190         


Arg Ser Val Lys Lys Lys Lys Lys Asn Ile Gln Glu Ser Ser Val Asn 
        195                 200                 205             


Leu Ile Thr Leu His Glu Met Leu Glu Ile Leu Ile Asn Arg Leu Phe 
    210                 215                 220                 


Asp Val Pro His Asp Pro Tyr Val Lys Ile Ser Asp Ser Phe Trp Pro 
225                 230                 235                 240 


Pro Tyr Val Glu Leu Leu Leu Arg Asn Gly Ile Ala Leu Arg His Pro 
                245                 250                 255     


Glu Asp Pro Thr Arg Ile Arg Leu Glu Ala Phe His Gln 
            260                 265                 


<210> 4784
<211> 346
<212> PRT
<213> Homo sapiens

<400> 4784
Met Cys Glu Gly Pro Ser Arg Ile Ser Gly Pro Ile Pro Pro Asp Pro 
1               5                   10                  15      


Thr Leu Cys Pro Asp Asn Tyr Arg Arg Pro Thr Ser Ala Gln Gly Arg 
            20                  25                  30          


Leu Glu Gly Asn Ala Leu Lys Leu Asp Leu Leu Thr Ser Asp Arg Ala 
        35                  40                  45              


Leu Asp Thr Thr Ala Pro Arg Gly Pro Cys Ile Gly Pro Gly Ala Gly 
    50                  55                  60                  


Glu Ile Leu Glu Arg Gly Gln Arg Gly Val Gly Asp Val Leu Leu Gln 
65                  70                  75                  80  


Leu Glu Gly Ile Ser Leu Gly Pro Gly Ala Ser Leu Lys Arg Lys Asp 
                85                  90                  95      


Pro Lys Asp His Glu Lys Glu Asn Leu Arg Arg Ile Arg Glu Ile Gln 
            100                 105                 110         


Lys Arg Phe Arg Glu Gln Glu Arg Ser Arg Glu Gln Gly Gln Pro Arg 
        115                 120                 125             


Pro Leu Lys Ala Leu Trp Arg Ser Pro Lys Tyr Asp Lys Val Glu Ser 
    130                 135                 140                 


Arg Val Lys Ala Gln Leu Gln Glu Pro Gly Pro Ala Ser Gly Thr Glu 
145                 150                 155                 160 


Ser Ala His Phe Leu Arg Ala His Ser Arg Cys Gly Pro Gly Leu Pro 
                165                 170                 175     


Pro Pro His Val Ser Ser Pro Gln Pro Thr Pro Pro Gly Pro Glu Ala 
            180                 185                 190         


Lys Glu Pro Gly Leu Gly Val Asp Phe Ile Arg His Asn Ala Arg Ala 
        195                 200                 205             


Ala Lys Arg Ala Pro Arg Arg His Ser Cys Ser Leu Gln Val Leu Ala 
    210                 215                 220                 


Gln Val Leu Glu Gln Gln Arg Gln Ala Gln Glu His Tyr Asn Ala Thr 
225                 230                 235                 240 


Gln Lys Gly His Val Pro His Tyr Leu Leu Glu Arg Arg Asp Leu Trp 
                245                 250                 255     


Arg Arg Glu Ala Glu Ala Arg Lys Gln Ser Gln Pro Asp Pro Ala Met 
            260                 265                 270         


Pro Pro Gly His Thr Arg Met Pro Glu Asn Gln Arg Leu Glu Thr Leu 
        275                 280                 285             


Thr Lys Leu Leu Gln Ser Gln Ser Gln Leu Leu Arg Glu Leu Val Leu 
    290                 295                 300                 


Leu Pro Ala Gly Ala Asp Ser Leu Arg Ala Gln Ser His Arg Ala Glu 
305                 310                 315                 320 


Leu Asp Arg Lys Leu Val Gln Val Glu Glu Ala Ile Lys Ile Phe Ser 
                325                 330                 335     


Arg Pro Lys Val Phe Val Lys Met Asp Asp 
            340                 345     


<210> 4785
<211> 607
<212> PRT
<213> Homo sapiens

<400> 4785
Met Ala Ala Asn Val Phe Pro Phe Arg Asp Ala Arg Ala Ala Pro Asp 
1               5                   10                  15      


Pro Val Leu Glu Ala Gly Pro Val Ala His Gly Pro Leu Pro Val Pro 
            20                  25                  30          


Leu Val Leu Asp Asn Gly Ser Phe Gln Val Arg Ala Gly Trp Ala Cys 
        35                  40                  45              


Pro Gly Gln Asp Pro Gly Pro Glu Pro Arg Leu Gln Phe Arg Ala Val 
    50                  55                  60                  


Cys Ala Arg Gly Arg Gly Gly Ala Arg Gly Ala Ser Gly Pro Gln Val 
65                  70                  75                  80  


Gly Asn Ala Leu Gly Ser Leu Glu Pro Leu Arg Trp Met Leu Arg Ser 
                85                  90                  95      


Pro Phe Asp Arg Asn Val Pro Val Asn Leu Glu Leu Gln Glu Leu Leu 
            100                 105                 110         


Leu Asp Tyr Ser Phe Gln His Leu Gly Val Ser Ser Gln Gly Cys Val 
        115                 120                 125             


Asp His Pro Ile Val Leu Thr Glu Ala Val Cys Asn Pro Leu Tyr Ser 
    130                 135                 140                 


Arg Gln Met Met Ser Glu Leu Leu Phe Glu Cys Tyr Gly Ile Pro Lys 
145                 150                 155                 160 


Val Ala Tyr Gly Ile Asp Ser Leu Phe Ser Phe Tyr His Asn Lys Pro 
                165                 170                 175     


Lys Asn Ser Met Cys Ser Gly Leu Ile Ile Ser Ser Gly Tyr Gln Cys 
            180                 185                 190         


Thr His Val Leu Pro Ile Leu Glu Gly Arg Leu Asp Ala Lys Asn Cys 
        195                 200                 205             


Lys Arg Ile Asn Leu Gly Gly Ser Gln Ala Ala Gly Tyr Leu Gln Arg 
    210                 215                 220                 


Leu Leu Gln Leu Lys Tyr Pro Gly His Leu Ala Ala Ile Thr Leu Ser 
225                 230                 235                 240 


Arg Met Glu Glu Ile Leu His Glu His Ser Tyr Ile Ala Glu Asp Tyr 
                245                 250                 255     


Val Glu Glu Leu His Lys Trp Arg Cys Pro Asp Tyr Tyr Glu Asn Asn 
            260                 265                 270         


Val His Lys Met Gln Leu Pro Phe Ser Ser Lys Leu Leu Gly Ser Thr 
        275                 280                 285             


Leu Thr Ser Glu Glu Lys Gln Glu Arg Arg Gln Gln Gln Leu Arg Arg 
    290                 295                 300                 


Leu Gln Glu Leu Asn Ala Arg Arg Arg Glu Glu Lys Leu Gln Leu Asp 
305                 310                 315                 320 


Gln Glu Arg Leu Asp Arg Leu Leu Tyr Val Gln Glu Leu Leu Glu Asp 
                325                 330                 335     


Gly Gln Met Asp Gln Phe His Lys Ala Leu Ile Glu Leu Asn Met Asp 
            340                 345                 350         


Ser Pro Glu Glu Leu Gln Ser Tyr Ile Gln Lys Leu Ser Ile Ala Val 
        355                 360                 365             


Glu Gln Ala Lys Gln Lys Ile Leu Gln Ala Glu Val Asn Leu Glu Val 
    370                 375                 380                 


Asp Val Val Asp Ser Lys Pro Glu Thr Pro Asp Leu Glu Gln Leu Glu 
385                 390                 395                 400 


Pro Ser Leu Glu Asp Val Glu Ser Met Asn Asp Phe Asp Pro Leu Phe 
                405                 410                 415     


Ser Glu Glu Thr Pro Gly Val Glu Lys Pro Val Thr Thr Val Gln Pro 
            420                 425                 430         


Val Phe Asn Leu Ala Ala Tyr His Gln Leu Phe Val Gly Thr Glu Arg 
        435                 440                 445             


Ile Arg Ala Pro Glu Ile Ile Phe Gln Pro Ser Leu Ile Gly Glu Glu 
    450                 455                 460                 


Gln Ala Gly Ile Ala Glu Thr Leu Gln Tyr Ile Leu Asp Arg Tyr Pro 
465                 470                 475                 480 


Lys Asp Ile Gln Glu Met Leu Val Gln Asn Val Phe Leu Thr Gly Gly 
                485                 490                 495     


Asn Thr Met Tyr Pro Gly Met Lys Ala Arg Met Glu Lys Glu Leu Leu 
            500                 505                 510         


Glu Met Arg Pro Phe Arg Ser Ser Phe Gln Val Gln Leu Ala Ser Asn 
        515                 520                 525             


Pro Val Leu Asp Ala Trp Tyr Gly Ala Arg Asp Trp Ala Leu Asn His 
    530                 535                 540                 


Leu Asp Asp Asn Glu Val Trp Ile Thr Arg Lys Glu Tyr Glu Glu Lys 
545                 550                 555                 560 


Gly Gly Glu Tyr Leu Lys Glu His Cys Ala Ser Asn Ile Tyr Val Pro 
                565                 570                 575     


Ile Arg Leu Pro Lys Gln Ala Ser Arg Ser Ser Asp Ala Gln Ala Ser 
            580                 585                 590         


Ser Lys Gly Ser Ala Ala Gly Gly Gly Gly Ala Gly Glu Gln Ala 
        595                 600                 605         


<210> 4786
<211> 460
<212> PRT
<213> Homo sapiens

<400> 4786
Met Ala Ser Arg Glu Glu Val Leu Ala Leu Gln Ala Glu Val Ala Gln 
1               5                   10                  15      


Arg Glu Glu Glu Leu Asn Ser Leu Lys Gln Lys Leu Ala Ser Ala Leu 
            20                  25                  30          


Leu Ala Glu Gln Glu Pro Gln Pro Glu Arg Leu Val Pro Val Ser Pro 
        35                  40                  45              


Leu Pro Pro Lys Ala Ala Leu Ser Arg Asp Glu Ile Leu Arg Tyr Ser 
    50                  55                  60                  


Arg Gln Leu Val Leu Pro Glu Leu Gly Val His Gly Gln Leu Arg Leu 
65                  70                  75                  80  


Gly Thr Ala Cys Val Leu Ile Val Gly Cys Gly Gly Leu Gly Cys Pro 
                85                  90                  95      


Leu Ala Gln Tyr Leu Ala Ala Ala Gly Val Gly Arg Leu Gly Leu Val 
            100                 105                 110         


Asp Tyr Asp Val Val Glu Met Ser Asn Leu Ala Arg Gln Val Leu His 
        115                 120                 125             


Gly Glu Ala Leu Ala Gly Gln Ala Lys Ala Phe Ser Ala Ala Ala Ser 
    130                 135                 140                 


Leu Arg Arg Leu Asn Ser Ala Val Glu Cys Val Pro Tyr Thr Gln Ala 
145                 150                 155                 160 


Leu Thr Pro Ala Thr Ala Leu Asp Leu Val Arg Arg Tyr Asp Val Val 
                165                 170                 175     


Ala Asp Cys Ser Asp Asn Val Pro Thr Arg Tyr Leu Val Asn Asp Ala 
            180                 185                 190         


Cys Val Leu Ala Gly Arg Pro Leu Val Ser Ala Ser Ala Leu Arg Phe 
        195                 200                 205             


Glu Gly Gln Ile Thr Val Tyr His Tyr Asp Gly Gly Pro Cys Tyr Arg 
    210                 215                 220                 


Cys Ile Phe Pro Gln Pro Pro Pro Ala Glu Thr Val Thr Asn Cys Ala 
225                 230                 235                 240 


Asp Gly Gly Val Leu Gly Val Val Thr Gly Val Leu Gly Cys Leu Gln 
                245                 250                 255     


Ala Leu Glu Val Leu Lys Ile Ala Ala Gly Leu Gly Pro Ser Tyr Ser 
            260                 265                 270         


Gly Ser Leu Leu Leu Phe Asp Ala Leu Arg Gly His Phe Arg Ser Ile 
        275                 280                 285             


Arg Leu Arg Ser Arg Arg Leu Asp Cys Ala Ala Cys Gly Glu Arg Pro 
    290                 295                 300                 


Thr Val Thr Asp Leu Leu Asp Tyr Glu Ala Phe Cys Gly Ser Ser Ala 
305                 310                 315                 320 


Thr Asp Lys Cys Arg Ser Leu Gln Leu Leu Ser Pro Glu Glu Arg Val 
                325                 330                 335     


Ser Val Thr Asp Tyr Lys Arg Leu Leu Asp Ser Gly Ala Phe His Leu 
            340                 345                 350         


Leu Leu Asp Val Arg Pro Gln Val Glu Val Asp Ile Cys Arg Leu Pro 
        355                 360                 365             


His Ala Leu His Ile Pro Leu Lys His Leu Glu Arg Arg Asp Ala Glu 
    370                 375                 380                 


Ser Leu Lys Leu Leu Lys Glu Ala Ile Trp Glu Glu Lys Gln Gly Thr 
385                 390                 395                 400 


Gln Glu Gly Ala Ala Val Pro Ile Tyr Val Ile Cys Lys Leu Gly Asn 
                405                 410                 415     


Asp Ser Gln Lys Ala Val Lys Ile Leu Gln Ser Leu Ser Ala Ala Gln 
            420                 425                 430         


Glu Leu Asp Pro Leu Thr Val Arg Asp Val Val Gly Gly Leu Met Ala 
        435                 440                 445             


Trp Ala Ala Lys Ile Asp Gly Thr Phe Pro Gln Tyr 
    450                 455                 460 


<210> 4787
<211> 346
<212> PRT
<213> Homo sapiens

<400> 4787
Met Glu Ser Val Ser Cys Ser Ala Ala Ala Val Arg Thr Gly Asp Met 
1               5                   10                  15      


Glu Ser Gln Arg Asp Leu Ser Leu Val Pro Glu Arg Leu Gln Arg Arg 
            20                  25                  30          


Glu Gln Glu Arg Gln Leu Glu Val Glu Arg Arg Lys Gln Lys Arg Gln 
        35                  40                  45              


Asn Gln Glu Val Glu Lys Glu Asn Ser His Phe Phe Val Ala Thr Phe 
    50                  55                  60                  


Val Arg Glu Arg Ala Ala Val Glu Glu Leu Leu Glu Arg Ala Glu Ser 
65                  70                  75                  80  


Val Glu Arg Leu Glu Glu Ala Ala Ser Arg Leu Gln Gly Leu Gln Lys 
                85                  90                  95      


Leu Ile Asn Asp Ser Val Phe Phe Leu Ala Ala Tyr Asp Leu Arg Gln 
            100                 105                 110         


Gly Gln Glu Ala Leu Ala Arg Leu Gln Ala Ala Leu Ala Glu Arg Arg 
        115                 120                 125             


Arg Gly Leu Gln Pro Lys Lys Arg Phe Ala Phe Lys Thr Arg Gly Lys 
    130                 135                 140                 


Asp Ala Ala Ser Ser Thr Lys Val Asp Ala Ala Pro Gly Ile Pro Pro 
145                 150                 155                 160 


Ala Val Glu Ser Ile Gln Asp Ser Pro Leu Pro Lys Lys Ala Glu Gly 
                165                 170                 175     


Asp Leu Gly Pro Ser Trp Val Cys Gly Phe Ser Asn Leu Glu Ser Gln 
            180                 185                 190         


Val Leu Glu Lys Arg Ala Ser Glu Leu His Gln Arg Asp Val Leu Leu 
        195                 200                 205             


Thr Glu Leu Ser Asn Cys Thr Val Arg Leu Tyr Gly Asn Pro Asn Thr 
    210                 215                 220                 


Leu Arg Leu Thr Lys Ala His Ser Cys Lys Leu Leu Cys Gly Pro Val 
225                 230                 235                 240 


Ser Thr Ser Val Phe Leu Glu Asp Cys Ser Asp Cys Val Leu Ala Val 
                245                 250                 255     


Ala Cys Gln Gln Leu Arg Ile His Ser Thr Lys Asp Thr Arg Ile Phe 
            260                 265                 270         


Leu Gln Val Thr Ser Arg Ala Ile Val Glu Asp Cys Ser Gly Ile Gln 
        275                 280                 285             


Phe Ala Pro Tyr Thr Trp Ser Tyr Pro Glu Ile Asp Lys Asp Phe Glu 
    290                 295                 300                 


Ser Ser Gly Leu Asp Arg Ser Lys Asn Asn Trp Asn Asp Val Asp Asp 
305                 310                 315                 320 


Phe Asn Trp Leu Ala Arg Asp Met Ala Ser Pro Asn Trp Ser Ile Leu 
                325                 330                 335     


Pro Glu Glu Glu Arg Asn Ile Gln Trp Asp 
            340                 345     


<210> 4788
<211> 248
<212> PRT
<213> Homo sapiens

<400> 4788
Met Thr Pro Lys Gly Pro Ala Met Cys Ser Met Pro Leu Thr Ser Ala 
1               5                   10                  15      


Asp Cys Phe Ser Asn Asp Ile His Lys Leu Asp Thr Ser Thr Met Thr 
            20                  25                  30          


Trp Thr Leu Ile Cys Thr Lys Gly Ser Pro Ala Arg Trp Arg Asp Phe 
        35                  40                  45              


His Ser Ala Thr Met Leu Gly Ser His Met Tyr Val Phe Gly Gly Arg 
    50                  55                  60                  


Ala Asp Arg Phe Gly Pro Phe His Ser Asn Asn Glu Ile Tyr Cys Asn 
65                  70                  75                  80  


Arg Ile Arg Val Phe Asp Thr Arg Thr Glu Ala Trp Leu Asp Cys Pro 
                85                  90                  95      


Pro Thr Pro Val Leu Pro Glu Gly Arg Arg Ser His Ser Ala Phe Gly 
            100                 105                 110         


Tyr Asn Gly Glu Leu Tyr Ile Phe Gly Gly Tyr Asn Ala Arg Leu Asn 
        115                 120                 125             


Arg His Phe His Asp Leu Trp Lys Phe Asn Pro Val Ser Phe Thr Trp 
    130                 135                 140                 


Lys Lys Ile Glu Pro Lys Gly Lys Gly Pro Cys Pro Arg Arg Arg Gln 
145                 150                 155                 160 


Cys Cys Cys Ile Val Gly Asp Lys Ile Val Leu Phe Gly Gly Thr Ser 
                165                 170                 175     


Pro Ser Pro Glu Glu Gly Leu Gly Asp Glu Phe Asp Leu Ile Asp His 
            180                 185                 190         


Ser Asp Leu His Ile Leu Asp Phe Ser Pro Ser Leu Lys Thr Leu Cys 
        195                 200                 205             


Lys Leu Ala Val Ile Gln Tyr Asn Leu Asp Gln Ser Cys Leu Pro His 
    210                 215                 220                 


Asp Ile Arg Trp Glu Leu Asn Ala Met Thr Thr Asn Ser Asn Ile Ser 
225                 230                 235                 240 


Arg Pro Ile Val Ser Ser His Gly 
                245             


<210> 4789
<211> 466
<212> PRT
<213> Homo sapiens

<400> 4789
Met Glu Tyr Glu Ser Tyr Tyr Phe Val Lys Phe Gln Lys Tyr Pro Lys 
1               5                   10                  15      


Ile Val Lys Lys Ser Ser Asp Thr Ala Glu Asn Asn Leu Pro Gln Arg 
            20                  25                  30          


Ser Arg Gly Lys Thr Arg Arg Met Met Asn Asp Ser Cys Gln Asn Leu 
        35                  40                  45              


Pro Lys Ile Asn Gln Gln Arg Pro Arg Ser Lys Thr Thr Ala Gly Lys 
    50                  55                  60                  


Thr Gly Asp Thr Lys Ser Leu Asn Lys Glu His Pro Asn Gln Glu Val 
65                  70                  75                  80  


Val Asp Asn Thr Arg Leu Glu Ser Ala Asn Phe Gly Leu His Ile Ser 
                85                  90                  95      


Arg Ile Arg Lys Asp Ser Gly Glu Glu Asn Ala His Pro Arg Arg Gly 
            100                 105                 110         


Gln Ile Ile Asp Phe Gln Gly Leu Leu Thr Asp Ala Ile Lys Gly Ala 
        115                 120                 125             


Thr Ser Glu Leu Ala Leu Asn Thr Phe Asp His Asn Pro Asp Pro Ser 
    130                 135                 140                 


Glu Arg Leu Leu Lys Pro Leu Ser Ala Phe Ile Gly Met Asn Ser Glu 
145                 150                 155                 160 


Met Arg Glu Leu Ala Ala Val Val Ser Arg Asp Ile Tyr Leu His Asn 
                165                 170                 175     


Pro Asn Ile Lys Trp Asn Asp Ile Ile Gly Leu Asp Ala Ala Lys Gln 
            180                 185                 190         


Leu Val Lys Glu Ala Val Val Tyr Pro Ile Arg Tyr Pro Gln Leu Phe 
        195                 200                 205             


Thr Gly Ile Leu Ser Pro Trp Lys Gly Leu Leu Leu Tyr Gly Pro Pro 
    210                 215                 220                 


Gly Thr Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Thr Glu Cys Lys 
225                 230                 235                 240 


Thr Thr Phe Phe Asn Ile Ser Ala Ser Thr Ile Val Ser Lys Trp Arg 
                245                 250                 255     


Gly Asp Ser Glu Lys Leu Val Arg Val Leu Phe Glu Leu Ala Arg Tyr 
            260                 265                 270         


His Ala Pro Ser Thr Ile Phe Leu Asp Glu Leu Glu Ser Val Met Ser 
        275                 280                 285             


Gln Arg Gly Thr Ala Ser Gly Gly Glu His Glu Gly Ser Leu Arg Met 
    290                 295                 300                 


Lys Thr Glu Leu Leu Val Gln Met Asp Gly Leu Ala Arg Ser Glu Asp 
305                 310                 315                 320 


Leu Val Phe Val Leu Ala Ala Ser Asn Leu Pro Trp Glu Leu Asp Cys 
                325                 330                 335     


Ala Met Leu Arg Arg Leu Glu Lys Arg Ile Leu Val Asp Leu Pro Ser 
            340                 345                 350         


Arg Glu Ala Arg Gln Ala Met Ile Tyr His Trp Leu Pro Pro Val Ser 
        355                 360                 365             


Lys Ser Arg Ala Leu Glu Leu His Thr Glu Leu Glu Tyr Ser Val Leu 
    370                 375                 380                 


Ser Gln Glu Thr Glu Gly Tyr Ser Gly Ser Asp Ile Lys Leu Val Cys 
385                 390                 395                 400 


Arg Glu Ala Ala Met Arg Pro Val Arg Lys Ile Phe Asp Ala Leu Glu 
                405                 410                 415     


Asn His Gln Ser Glu Ser Ser Asp Leu Pro Arg Ile Gln Leu Asp Ile 
            420                 425                 430         


Val Thr Thr Ala Asp Phe Leu Asp Val Leu Thr His Thr Lys Pro Ser 
        435                 440                 445             


Ala Lys Asn Leu Ala Gln Arg Tyr Ser Asp Trp Gln Arg Glu Phe Glu 
    450                 455                 460                 


Ser Val 
465     


<210> 4790
<211> 2133
<212> PRT
<213> Homo sapiens

<400> 4790
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu 
            100                 105                 110         


Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser 
    130                 135                 140                 


Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln 
145                 150                 155                 160 


Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser 
                165                 170                 175     


Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu 
            180                 185                 190         


Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val 
        195                 200                 205             


Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu 
    210                 215                 220                 


Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu 
225                 230                 235                 240 


Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser 
                245                 250                 255     


Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser 
            260                 265                 270         


Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser 
        275                 280                 285             


Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His 
    290                 295                 300                 


Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu 
305                 310                 315                 320 


Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn 
                325                 330                 335     


Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val 
            340                 345                 350         


Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu 
        355                 360                 365             


Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu 
    370                 375                 380                 


Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met 
385                 390                 395                 400 


Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu 
                405                 410                 415     


Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala 
            420                 425                 430         


Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala 
        435                 440                 445             


Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr 
    450                 455                 460                 


Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn 
465                 470                 475                 480 


Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Lys Leu Ala Glu 
                485                 490                 495     


Tyr Glu Asn Leu Thr Asn Lys Leu Gln Arg Asn Leu Glu Asn Val Leu 
            500                 505                 510         


Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu 
        515                 520                 525             


Gln Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys 
    530                 535                 540                 


Arg Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu 
545                 550                 555                 560 


Tyr Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro 
                565                 570                 575     


Ser Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly 
            580                 585                 590         


Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu 
        595                 600                 605             


Leu Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys 
    610                 615                 620                 


Leu Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu 
625                 630                 635                 640 


Asp Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln 
                645                 650                 655     


Arg His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu 
            660                 665                 670         


Lys Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu 
        675                 680                 685             


Ala His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu 
    690                 695                 700                 


Gln Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg 
705                 710                 715                 720 


Leu Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala 
                725                 730                 735     


Ser Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu 
            740                 745                 750         


Glu Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu 
        755                 760                 765             


Gln Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu 
    770                 775                 780                 


Arg Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg 
785                 790                 795                 800 


Glu Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala 
                805                 810                 815     


Gln Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala 
            820                 825                 830         


Leu Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln 
        835                 840                 845             


Glu Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu 
    850                 855                 860                 


Leu Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu 
865                 870                 875                 880 


Lys Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met 
                885                 890                 895     


Leu Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg 
            900                 905                 910         


Gln Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr 
        915                 920                 925             


Gln Gln Ser Leu Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His 
    930                 935                 940                 


Lys Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala 
945                 950                 955                 960 


Ser Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His 
                965                 970                 975     


Asp Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn 
            980                 985                 990         


Ile His Lys Ala Thr Cys Glu Thr  Ala Asp Arg Glu Arg  Ala Glu Met 
        995                 1000                 1005             


Ser Thr  Glu Ile Ser Arg Leu  Gln Ser Lys Ile Lys  Glu Met Gln 
    1010                 1015                 1020             


Gln Ala  Thr Ser Pro Leu Ser  Met Leu Gln Ser Gly  Cys Gln Val 
    1025                 1030                 1035             


Ile Gly  Glu Glu Glu Val Glu  Gly Asp Gly Ala Leu  Ser Leu Leu 
    1040                 1045                 1050             


Gln Gln  Gly Glu Gln Leu Leu  Glu Glu Asn Gly Asp  Val Leu Leu 
    1055                 1060                 1065             


Ser Leu  Gln Arg Ala His Glu  Gln Ala Val Lys Glu  Asn Val Lys 
    1070                 1075                 1080             


Met Ala  Thr Glu Ile Ser Arg  Leu Gln Gln Arg Leu  Gln Lys Leu 
    1085                 1090                 1095             


Glu Pro  Gly Leu Val Met Ser  Ser Cys Leu Asp Glu  Pro Ala Thr 
    1100                 1105                 1110             


Glu Phe  Phe Gly Asn Thr Ala  Glu Gln Thr Glu Gln  Phe Leu Gln 
    1115                 1120                 1125             


Gln Asn  Arg Thr Lys Gln Val  Glu Gly Val Thr Arg  Arg His Val 
    1130                 1135                 1140             


Leu Ser  Asp Leu Glu Asp Asp  Glu Val Arg Asp Leu  Gly Ser Thr 
    1145                 1150                 1155             


Gly Thr  Ser Ser Val Gln Arg  Gln Glu Val Lys Ile  Glu Glu Ser 
    1160                 1165                 1170             


Glu Ala  Ser Val Glu Gly Phe  Ser Glu Leu Glu Asn  Ser Glu Glu 
    1175                 1180                 1185             


Thr Arg  Thr Glu Ser Trp Glu  Leu Lys Asn Gln Ile  Ser Gln Leu 
    1190                 1195                 1200             


Gln Glu  Gln Leu Met Met Leu  Cys Ala Asp Cys Asp  Arg Ala Ser 
    1205                 1210                 1215             


Glu Lys  Lys Gln Asp Leu Leu  Phe Asp Val Ser Val  Leu Lys Lys 
    1220                 1225                 1230             


Lys Leu  Lys Met Leu Glu Arg  Ile Pro Glu Ala Ser  Pro Lys Tyr 
    1235                 1240                 1245             


Lys Leu  Leu Tyr Glu Asp Val  Ser Arg Glu Asn Asp  Cys Leu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Arg Met Met Glu  Thr Arg Tyr Asp Glu  Ala Leu Glu 
    1265                 1270                 1275             


Asn Asn  Lys Glu Leu Thr Ala  Glu Val Phe Arg Leu  Gln Asp Glu 
    1280                 1285                 1290             


Leu Lys  Lys Met Glu Glu Val  Thr Glu Thr Phe Leu  Ser Leu Glu 
    1295                 1300                 1305             


Lys Ser  Tyr Asp Glu Val Lys  Ile Glu Asn Glu Gly  Leu Asn Val 
    1310                 1315                 1320             


Leu Val  Leu Arg Leu Gln Gly  Lys Ile Glu Lys Leu  Gln Glu Ser 
    1325                 1330                 1335             


Val Val  Gln Arg Cys Asp Cys  Cys Leu Trp Glu Ala  Ser Leu Glu 
    1340                 1345                 1350             


Asn Leu  Glu Ile Glu Pro Asp  Gly Asn Ile Leu Gln  Leu Asn Gln 
    1355                 1360                 1365             


Thr Leu  Glu Glu Cys Val Pro  Arg Val Arg Ser Val  His His Val 
    1370                 1375                 1380             


Ile Glu  Glu Cys Lys Gln Glu  Asn Gln Tyr Leu Glu  Gly Asn Thr 
    1385                 1390                 1395             


Gln Leu  Leu Glu Lys Val Lys  Ala His Glu Ile Ala  Trp Leu His 
    1400                 1405                 1410             


Gly Thr  Ile Gln Thr His Gln  Glu Arg Pro Arg Val  Gln Asn Gln 
    1415                 1420                 1425             


Val Ile  Leu Glu Glu Asn Thr  Thr Leu Leu Gly Phe  Gln Asp Lys 
    1430                 1435                 1440             


His Phe  Gln His Gln Ala Thr  Ile Ala Glu Leu Glu  Leu Glu Lys 
    1445                 1450                 1455             


Thr Lys  Leu Gln Glu Leu Thr  Arg Lys Leu Lys Glu  Arg Val Thr 
    1460                 1465                 1470             


Ile Leu  Val Lys Gln Lys Asp  Val Leu Ser His Gly  Glu Lys Glu 
    1475                 1480                 1485             


Glu Glu  Leu Lys Ala Met Met  His Asp Leu Gln Ile  Thr Cys Ser 
    1490                 1495                 1500             


Glu Met  Gln Gln Lys Val Glu  Leu Leu Arg Tyr Glu  Ser Glu Lys 
    1505                 1510                 1515             


Leu Gln  Gln Glu Asn Ser Ile  Leu Arg Asn Glu Ile  Thr Thr Leu 
    1520                 1525                 1530             


Asn Glu  Glu Asp Ser Ile Ser  Asn Leu Lys Leu Gly  Thr Leu Asn 
    1535                 1540                 1545             


Gly Ser  Gln Glu Glu Met Trp  Gln Lys Thr Glu Thr  Val Lys Gln 
    1550                 1555                 1560             


Glu Asn  Ala Ala Val Gln Lys  Met Val Glu Asn Leu  Lys Lys Gln 
    1565                 1570                 1575             


Ile Ser  Glu Leu Lys Ile Lys  Asn Gln Gln Leu Asp  Leu Glu Asn 
    1580                 1585                 1590             


Thr Glu  Leu Ser Gln Lys Asn  Ser Gln Asn Gln Glu  Lys Leu Gln 
    1595                 1600                 1605             


Glu Leu  Asn Gln Arg Leu Thr  Glu Met Leu Cys Gln  Lys Glu Lys 
    1610                 1615                 1620             


Glu Pro  Gly Asn Ser Ala Leu  Glu Glu Arg Glu Gln  Glu Lys Phe 
    1625                 1630                 1635             


Asn Leu  Lys Glu Glu Leu Glu  Arg Cys Lys Val Gln  Ser Ser Thr 
    1640                 1645                 1650             


Leu Val  Ser Ser Leu Glu Ala  Glu Leu Ser Glu Val  Lys Ile Gln 
    1655                 1660                 1665             


Thr His  Ile Val Gln Gln Glu  Asn His Leu Leu Lys  Asp Glu Leu 
    1670                 1675                 1680             


Glu Lys  Met Lys Gln Leu His  Arg Cys Pro Asp Leu  Ser Asp Phe 
    1685                 1690                 1695             


Gln Gln  Lys Ile Ser Ser Val  Leu Ser Tyr Asn Glu  Lys Leu Leu 
    1700                 1705                 1710             


Lys Glu  Lys Glu Ala Leu Ser  Glu Glu Leu Asn Ser  Cys Val Asp 
    1715                 1720                 1725             


Lys Leu  Ala Lys Ser Ser Leu  Leu Glu His Arg Ile  Ala Thr Met 
    1730                 1735                 1740             


Lys Gln  Glu Gln Lys Ser Trp  Glu His Gln Ser Ala  Ser Leu Lys 
    1745                 1750                 1755             


Ser Gln  Leu Val Ala Ser Gln  Glu Lys Val Gln Asn  Leu Glu Asp 
    1760                 1765                 1770             


Thr Val  Gln Asn Val Asn Leu  Gln Met Ser Arg Met  Lys Ser Asp 
    1775                 1780                 1785             


Leu Arg  Val Thr Gln Gln Glu  Lys Glu Ala Leu Lys  Gln Glu Val 
    1790                 1795                 1800             


Met Ser  Leu His Lys Gln Leu  Gln Asn Ala Gly Gly  Lys Ser Trp 
    1805                 1810                 1815             


Ala Pro  Glu Ile Ala Thr His  Pro Ser Gly Leu His  Asn Gln Gln 
    1820                 1825                 1830             


Lys Arg  Leu Ser Trp Asp Lys  Leu Asp His Leu Met  Asn Glu Glu 
    1835                 1840                 1845             


Gln Gln  Leu Leu Trp Gln Glu  Asn Glu Arg Leu Gln  Thr Met Val 
    1850                 1855                 1860             


Gln Asn  Thr Lys Ala Glu Leu  Thr His Ser Arg Glu  Lys Val Arg 
    1865                 1870                 1875             


Gln Leu  Glu Ser Asn Leu Leu  Pro Lys His Gln Lys  His Leu Asn 
    1880                 1885                 1890             


Pro Ser  Gly Thr Met Asn Pro  Thr Glu Gln Glu Lys  Leu Ser Leu 
    1895                 1900                 1905             


Lys Arg  Glu Cys Asp Gln Phe  Gln Lys Glu Gln Ser  Pro Ala Asn 
    1910                 1915                 1920             


Arg Lys  Val Ser Gln Met Asn  Ser Leu Glu Gln Glu  Leu Glu Thr 
    1925                 1930                 1935             


Ile His  Leu Glu Asn Glu Gly  Leu Lys Lys Lys Gln  Val Lys Leu 
    1940                 1945                 1950             


Asp Glu  Gln Leu Met Glu Met  Gln His Leu Arg Ser  Thr Ala Thr 
    1955                 1960                 1965             


Pro Ser  Pro Ser Pro His Ala  Trp Asp Leu Gln Leu  Leu Gln Gln 
    1970                 1975                 1980             


Gln Ala  Cys Pro Met Val Pro  Arg Glu Gln Phe Leu  Gln Leu Gln 
    1985                 1990                 1995             


Arg Gln  Leu Leu Gln Ala Glu  Arg Ile Asn Gln His  Leu Gln Glu 
    2000                 2005                 2010             


Glu Leu  Glu Asn Arg Thr Ser  Glu Thr Asn Thr Pro  Gln Gly Asn 
    2015                 2020                 2025             


Gln Glu  Gln Leu Val Thr Val  Met Glu Glu Arg Met  Ile Glu Val 
    2030                 2035                 2040             


Glu Gln  Lys Leu Lys Leu Val  Lys Arg Leu Leu Gln  Glu Lys Val 
    2045                 2050                 2055             


Asn Gln  Leu Lys Glu Gln Leu  Cys Lys Asn Thr Lys  Ala Asp Ala 
    2060                 2065                 2070             


Met Val  Lys Asp Leu Tyr Val  Glu Asn Ala Gln Leu  Leu Lys Ala 
    2075                 2080                 2085             


Leu Glu  Val Thr Glu Gln Arg  Gln Lys Thr Ala Glu  Lys Lys Asn 
    2090                 2095                 2100             


Tyr Leu  Leu Glu Glu Lys Ile  Ala Ser Leu Ser Asn  Ile Val Arg 
    2105                 2110                 2115             


Asn Leu  Thr Pro Ala Pro Leu  Thr Ser Thr Pro Pro  Leu Arg Ser 
    2120                 2125                 2130             


<210> 4791
<211> 570
<212> PRT
<213> Homo sapiens

<400> 4791
Met Ala Gly Gly Ala Arg Glu Val Leu Thr Leu Gln Leu Gly His Phe 
1               5                   10                  15      


Ala Gly Phe Val Gly Ala His Trp Trp Asn Gln Gln Asp Ala Ala Leu 
            20                  25                  30          


Gly Arg Ala Thr Asp Ser Lys Glu Pro Pro Gly Glu Leu Cys Pro Asp 
        35                  40                  45              


Val Leu Tyr Arg Thr Gly Arg Thr Leu His Gly Gln Glu Thr Tyr Thr 
    50                  55                  60                  


Pro Arg Leu Ile Leu Met Asp Leu Lys Gly Ser Leu Ser Ser Leu Lys 
65                  70                  75                  80  


Glu Glu Gly Gly Leu Tyr Arg Asp Lys Gln Leu Asp Ala Ala Ile Ala 
                85                  90                  95      


Trp Gln Gly Lys Leu Thr Thr His Lys Glu Glu Leu Tyr Pro Lys Asn 
            100                 105                 110         


Pro Tyr Leu Gln Asp Phe Leu Ser Ala Glu Gly Val Leu Ser Ser Asp 
        115                 120                 125             


Gly Val Trp Arg Val Lys Ser Ile Pro Asn Gly Lys Gly Ser Ser Pro 
    130                 135                 140                 


Leu Pro Thr Ala Thr Thr Pro Lys Pro Leu Ile Pro Thr Glu Ala Ser 
145                 150                 155                 160 


Ile Arg Val Trp Ser Asp Phe Leu Arg Val His Leu His Pro Arg Ser 
                165                 170                 175     


Ile Cys Met Ile Gln Lys Tyr Asn His Asp Gly Glu Ala Gly Arg Leu 
            180                 185                 190         


Glu Ala Phe Gly Gln Gly Glu Ser Val Leu Lys Glu Pro Lys Tyr Gln 
        195                 200                 205             


Glu Glu Leu Glu Asp Arg Leu His Phe Tyr Val Glu Glu Cys Asp Tyr 
    210                 215                 220                 


Leu Gln Gly Phe Gln Ile Leu Cys Asp Leu His Asp Gly Phe Ser Gly 
225                 230                 235                 240 


Val Gly Ala Lys Ala Ala Glu Leu Leu Gln Asp Glu Tyr Ser Gly Arg 
                245                 250                 255     


Gly Ile Ile Thr Trp Gly Leu Leu Pro Gly Pro Tyr His Arg Gly Glu 
            260                 265                 270         


Ala Gln Arg Asn Ile Tyr Arg Leu Leu Asn Thr Ala Phe Gly Leu Val 
        275                 280                 285             


His Leu Thr Ala His Ser Ser Leu Val Cys Pro Leu Ser Leu Gly Gly 
    290                 295                 300                 


Ser Leu Gly Leu Arg Pro Glu Pro Pro Val Ser Phe Pro Tyr Leu His 
305                 310                 315                 320 


Tyr Asp Ala Thr Leu Pro Phe His Cys Ser Ala Ile Leu Ala Thr Ala 
                325                 330                 335     


Leu Asp Thr Val Thr Val Pro Tyr Arg Leu Cys Ser Ser Pro Val Ser 
            340                 345                 350         


Met Val His Leu Ala Asp Met Leu Ser Phe Cys Gly Lys Lys Val Val 
        355                 360                 365             


Thr Ala Gly Ala Ile Ile Pro Phe Pro Leu Ala Pro Gly Gln Ser Leu 
    370                 375                 380                 


Pro Asp Ser Leu Met Gln Phe Gly Gly Ala Thr Pro Trp Thr Pro Leu 
385                 390                 395                 400 


Ser Ala Cys Gly Glu Pro Ser Gly Thr Arg Cys Phe Ala Gln Ser Val 
                405                 410                 415     


Val Leu Arg Gly Ile Asp Arg Ala Cys His Thr Ser Gln Leu Thr Pro 
            420                 425                 430         


Gly Thr Pro Pro Pro Ser Ala Leu His Ala Cys Thr Thr Gly Glu Glu 
        435                 440                 445             


Ile Leu Ala Gln Tyr Leu Gln Gln Gln Gln Pro Gly Val Met Ser Ser 
    450                 455                 460                 


Ser His Leu Leu Leu Thr Pro Cys Arg Val Ala Pro Pro Tyr Pro His 
465                 470                 475                 480 


Leu Phe Ser Ser Cys Ser Pro Pro Gly Met Val Leu Asp Gly Ser Pro 
                485                 490                 495     


Lys Gly Ala Ala Val Glu Ser Ile Pro Val Phe Gly Ala Leu Cys Ser 
            500                 505                 510         


Ser Ser Ser Leu His Gln Thr Leu Glu Ala Leu Ala Arg Asp Leu Thr 
        515                 520                 525             


Lys Leu Asp Leu Arg Arg Trp Ala Ser Phe Met Asp Ala Gly Val Glu 
    530                 535                 540                 


His Asp Asp Val Ala Glu Leu Leu Gln Glu Leu Gln Ser Leu Ala Gln 
545                 550                 555                 560 


Cys Tyr Gln Gly Gly Asp Ser Leu Val Asp 
                565                 570 


<210> 4792
<211> 596
<212> PRT
<213> Homo sapiens

<400> 4792
Met Asn Arg Thr Trp Pro Arg Arg Ile Trp Gly Ser Ser Gln Asp Glu 
1               5                   10                  15      


Ala Glu Leu Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg 
            20                  25                  30          


Ser Gly Arg Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu 
        35                  40                  45              


Glu Leu Gln Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln 
    50                  55                  60                  


Arg Arg Pro Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala 
65                  70                  75                  80  


Gly Arg Gly Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala 
                85                  90                  95      


Gln Arg Pro Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser 
            100                 105                 110         


Pro Asp Leu Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu 
        115                 120                 125             


Arg Glu Val Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe 
    130                 135                 140                 


Val Ser Arg Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His 
145                 150                 155                 160 


Arg Glu Arg Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu 
                165                 170                 175     


Leu Thr Leu Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val 
            180                 185                 190         


Leu Gln Lys Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly 
        195                 200                 205             


Asn Ile Ala Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly 
    210                 215                 220                 


Pro Leu Gln Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser 
225                 230                 235                 240 


Ser Val Arg Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg 
                245                 250                 255     


Asp Asn Val Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp 
            260                 265                 270         


Ser Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro 
        275                 280                 285             


Tyr Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro 
    290                 295                 300                 


Gln Ser Arg Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu 
305                 310                 315                 320 


Arg Arg Arg Arg Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His 
                325                 330                 335     


Arg Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala 
            340                 345                 350         


Gly Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser 
        355                 360                 365             


Glu Leu Ser Val Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser 
    370                 375                 380                 


Arg Lys Trp Trp Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val 
385                 390                 395                 400 


Pro Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser 
                405                 410                 415     


Gln Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala 
            420                 425                 430         


Pro Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg 
        435                 440                 445             


Pro Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly Leu Asp Pro Ser Glu 
    450                 455                 460                 


Lys Glu Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala 
465                 470                 475                 480 


Arg Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro 
                485                 490                 495     


Arg Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val 
            500                 505                 510         


Arg Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala 
        515                 520                 525             


Leu Gly Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Lys Glu Glu 
    530                 535                 540                 


Leu Arg Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val 
545                 550                 555                 560 


Thr Val Gln Arg Ser Leu Leu Glu Asp Lys Glu Lys Val Ser Glu Leu 
                565                 570                 575     


Glu Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly Glu Val Glu 
            580                 585                 590         


Met Glu Val Ile 
        595     


<210> 4793
<211> 649
<212> PRT
<213> Homo sapiens

<400> 4793
Met Ser Ser Phe Gly Ala Gly Lys Thr Lys Glu Val Ile Phe Ser Val 
1               5                   10                  15      


Glu Asp Gly Ser Val Lys Met Phe Leu Arg Gly Arg Pro Val Pro Met 
            20                  25                  30          


Met Ile Pro Asp Glu Leu Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser 
        35                  40                  45              


Glu Leu Pro Ser Cys Arg Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg 
    50                  55                  60                  


Gly Arg Asp Cys Arg Ala Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile 
65                  70                  75                  80  


Val Tyr Phe Val Ala Ser Val Ala Val Leu Tyr Ser Val Glu Glu Gln 
                85                  90                  95      


Arg Gln Arg His Tyr Leu Gly His Asn Asp Asp Ile Lys Cys Leu Ala 
            100                 105                 110         


Ile His Pro Asp Met Val Thr Ile Ala Thr Gly Gln Val Ala Gly Thr 
        115                 120                 125             


Thr Lys Glu Gly Lys Pro Leu Pro Pro His Val Arg Ile Trp Asp Ser 
    130                 135                 140                 


Val Ser Leu Ser Thr Leu His Val Leu Gly Leu Gly Val Phe Asp Arg 
145                 150                 155                 160 


Ala Val Cys Cys Val Gly Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu 
                165                 170                 175     


Cys Ala Val Asp Glu Ser Asn Asp His Met Leu Ser Val Trp Asp Trp 
            180                 185                 190         


Ala Lys Glu Thr Lys Val Val Asp Val Lys Cys Ser Asn Glu Ala Val 
        195                 200                 205             


Leu Val Ala Thr Phe His Pro Thr Asp Pro Thr Val Leu Ile Thr Cys 
    210                 215                 220                 


Gly Lys Ser His Ile Tyr Phe Trp Thr Leu Glu Gly Gly Ser Leu Ser 
225                 230                 235                 240 


Lys Arg Gln Gly Leu Phe Glu Lys His Glu Lys Pro Lys Tyr Val Leu 
                245                 250                 255     


Cys Val Thr Phe Leu Glu Gly Gly Asp Val Val Thr Gly Asp Ser Gly 
            260                 265                 270         


Gly Asn Leu Tyr Val Trp Gly Lys Gly Gly Asn Arg Ile Thr Gln Ala 
        275                 280                 285             


Val Leu Gly Ala His Asp Gly Gly Val Phe Gly Leu Cys Ala Leu Arg 
    290                 295                 300                 


Asp Gly Thr Leu Val Ser Gly Gly Gly Arg Asp Arg Arg Val Val Leu 
305                 310                 315                 320 


Trp Gly Ser Asp Tyr Ser Lys Leu Gln Glu Val Glu Val Pro Glu Asp 
                325                 330                 335     


Phe Gly Pro Val Arg Thr Val Ala Glu Gly His Gly Asp Thr Leu Tyr 
            340                 345                 350         


Val Gly Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly 
        355                 360                 365             


Phe Ser Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala 
    370                 375                 380                 


Thr His Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu 
385                 390                 395                 400 


Val His Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile 
                405                 410                 415     


Ile Glu Asp Pro Ala Arg Ser Ala Gly Phe His Pro Ser Gly Ser Val 
            420                 425                 430         


Leu Ala Val Gly Thr Val Thr Gly Arg Trp Leu Leu Leu Asp Thr Glu 
        435                 440                 445             


Thr His Asp Leu Val Ala Ile His Thr Asp Gly Asn Glu Gln Ile Ser 
    450                 455                 460                 


Val Val Ser Phe Ser Pro Asp Gly Ala Tyr Leu Ala Val Gly Ser His 
465                 470                 475                 480 


Asp Asn Leu Val Tyr Val Tyr Thr Val Asp Gln Gly Gly Arg Lys Val 
                485                 490                 495     


Ser Arg Leu Gly Lys Cys Ser Gly His Ser Ser Phe Ile Thr His Leu 
            500                 505                 510         


Asp Trp Ala Gln Asp Ser Ser Cys Phe Val Thr Asn Ser Gly Asp Tyr 
        515                 520                 525             


Glu Ile Leu Tyr Trp Asp Pro Ala Thr Cys Lys Gln Ile Thr Ser Ala 
    530                 535                 540                 


Asp Ala Val Arg Asn Met Glu Trp Ala Thr Ala Thr Cys Val Leu Gly 
545                 550                 555                 560 


Phe Gly Val Phe Gly Ile Trp Ser Glu Gly Ala Asp Gly Thr Asp Ile 
                565                 570                 575     


Asn Ala Val Ala Arg Ser His Asp Gly Lys Leu Leu Ala Ser Ala Asp 
            580                 585                 590         


Asp Phe Gly Lys Val His Leu Phe Ser Tyr Pro Cys Cys Gln Pro Arg 
        595                 600                 605             


Ala Leu Ser His Lys Tyr Gly Gly His Ser Ser His Val Thr Asn Val 
    610                 615                 620                 


Ala Phe Leu Trp Asp Asp Ser Met Ala Leu Thr Thr Gly Gly Lys Asp 
625                 630                 635                 640 


Thr Ser Val Leu Gln Trp Arg Val Val 
                645                 


<210> 4794
<211> 263
<212> PRT
<213> Homo sapiens

<400> 4794
Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Phe Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Glu Tyr 
                85                  90                  95      


Gly Ser Gln Gln Val Ala Asp Leu Thr Leu Asn Leu Asp Asp Tyr Ile 
            100                 105                 110         


Asp Ala Glu His Leu Gly Asp Phe His Arg Thr Tyr Lys Asn Ser Glu 
        115                 120                 125             


Glu Leu Arg Ser Arg Ile Val Ser Gly Ile Ile Thr Pro Ile His Glu 
    130                 135                 140                 


Gln Trp Glu Lys Ala Asn Val Ser Ser Pro His Arg Glu Phe Pro Pro 
145                 150                 155                 160 


Ala Thr Ala Arg Glu Val Asp Pro Leu Arg Ile Pro Pro His His Pro 
                165                 170                 175     


His Thr Ser Arg Gln Pro Pro Trp Cys Asp Pro Leu Gly Pro Phe Val 
            180                 185                 190         


Val Gly Gly Glu Asp Leu Asp Pro Phe Gly Pro Arg Arg Gly Gly Met 
        195                 200                 205             


Ile Val Asp Pro Leu Arg Ser Gly Phe Pro Arg Ala Leu Ile Asp Pro 
    210                 215                 220                 


Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro Gly Ala Val Pro Pro Gly 
225                 230                 235                 240 


Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly Thr Ser Pro Pro Gly Pro 
                245                 250                 255     


Arg Pro Asp Arg Arg Gly Gln 
            260             


<210> 4795
<211> 90
<212> PRT
<213> Homo sapiens

<400> 4795
Met Asp Asn Met Ser Pro Arg Leu Arg Ala Phe Leu Ser Glu Pro Ile 
1               5                   10                  15      


Gly Glu Lys Asp Val Cys Trp Val Asp Gly Ile Ser His Glu Leu Ala 
            20                  25                  30          


Ile Asn Leu Val Thr Lys Gly Ile Asn Lys Ala Tyr Ile Leu Leu Gly 
        35                  40                  45              


Gln Phe Leu Leu Met His Lys Asn Glu Ala Glu Phe Gln Arg Trp Leu 
    50                  55                  60                  


Ile Cys Cys Phe Gly Ala Thr Glu Cys Glu Ala Gln Gln Thr Ser His 
65                  70                  75                  80  


Cys Leu Lys Glu Trp Cys Ala Cys Phe Leu 
                85                  90  


<210> 4796
<211> 295
<212> PRT
<213> Homo sapiens

<400> 4796
Met Pro Val His Thr Leu Ser Pro Gly Ala Pro Ser Ala Pro Ala Leu 
1               5                   10                  15      


Pro Cys Arg Leu Arg Thr Arg Val Pro Gly Tyr Leu Leu Arg Gly Pro 
            20                  25                  30          


Ala Asp Gly Gly Ala Arg Lys Pro Ser Ala Val Glu Arg Leu Glu Ala 
        35                  40                  45              


Asp Lys Ala Lys Tyr Val Lys Ser Leu His Val Ala Asn Thr Arg Gln 
    50                  55                  60                  


Glu Pro Val Gln Pro Leu Leu Ser Lys Gln Pro Leu Phe Ser Pro Glu 
65                  70                  75                  80  


Thr Arg Arg Thr Val Leu Thr Pro Ser Arg Arg Ala Leu Pro Gly Pro 
                85                  90                  95      


Cys Arg Arg Pro Gln Leu Asp Leu Asp Ile Leu Ser Ser Leu Ile Asp 
            100                 105                 110         


Leu Cys Asp Ser Pro Val Ser Pro Ala Glu Ala Ser Arg Thr Pro Gly 
        115                 120                 125             


Arg Ala Glu Gly Ala Gly Arg Pro Pro Pro Ala Thr Pro Pro Arg Pro 
    130                 135                 140                 


Pro Pro Ser Thr Ser Ala Val Arg Arg Val Asp Val Arg Pro Leu Pro 
145                 150                 155                 160 


Ala Ser Pro Ala Arg Pro Cys Pro Ser Pro Gly Pro Ala Ala Ala Ser 
                165                 170                 175     


Ser Pro Ala Arg Pro Pro Gly Leu Gln Arg Ser Lys Ser Asp Leu Ser 
            180                 185                 190         


Glu Arg Phe Ser Arg Ala Ala Ala Asp Leu Glu Arg Phe Phe Asn Phe 
        195                 200                 205             


Cys Gly Leu Asp Pro Glu Glu Ala Arg Gly Leu Gly Val Ala His Leu 
    210                 215                 220                 


Ala Arg Ala Ser Ser Asp Ile Val Ser Leu Ala Gly Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Gly Ser Ser Glu Gly Gly Cys Ser Arg Arg Ser Ser Val Thr Val 
                245                 250                 255     


Glu Glu Arg Ala Arg Glu Arg Val Pro Tyr Gly Val Ser Val Val Glu 
            260                 265                 270         


Arg Asn Ala Arg Val Ile Lys Trp Leu Tyr Gly Leu Arg Gln Ala Arg 
        275                 280                 285             


Glu Ser Pro Ala Ala Glu Gly 
    290                 295 


<210> 4797
<211> 193
<212> PRT
<213> Homo sapiens

<400> 4797
Met Pro Thr Thr Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Thr Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser 
    50                  55                  60                  


Ser Gly Ser Pro Ile Gly Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro 
65                  70                  75                  80  


Pro Ser Phe Asn Leu His Pro Ala Pro His Leu Leu Ala Ser Met His 
                85                  90                  95      


Leu Gln Lys Leu Asn Ser Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro 
            100                 105                 110         


Gly Gln Pro Gly Glu Ala Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala 
        115                 120                 125             


Gln Ala Gly Gly Ala Glu Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser 
    130                 135                 140                 


Pro Ala Ile Ile Asp Ser Asp Pro Val Asp Glu Glu Val Leu Met Ser 
145                 150                 155                 160 


Leu Val Val Glu Leu Gly Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu 
                165                 170                 175     


Trp Leu Gly Gln Asn Glu Phe Asp Phe Thr Ala Asp Phe Pro Ser Ser 
            180                 185                 190         


Cys 
    


<210> 4798
<211> 358
<212> PRT
<213> Homo sapiens

<400> 4798
Met Ala Ala Val Leu Lys Pro Val Leu Leu Gly Leu Arg Asp Ala Pro 
1               5                   10                  15      


Val His Gly Ser Pro Thr Gly Pro Gly Ala Trp Thr Ala Ser Lys Leu 
            20                  25                  30          


Gly Gly Ile Pro Asp Ala Leu Pro Thr Val Ala Ala Pro Arg Pro Val 
        35                  40                  45              


Cys Gln Arg Cys Gly Gln Pro Leu Ala Leu Val Val Gln Val Tyr Cys 
    50                  55                  60                  


Pro Leu Glu Gly Ser Pro Phe His Arg Leu Leu His Val Phe Ala Cys 
65                  70                  75                  80  


Ala Cys Pro Gly Cys Ser Thr Gly Gly Ala Arg Ser Trp Lys Val Phe 
                85                  90                  95      


Arg Ser Gln Cys Leu Gln Val Pro Glu Arg Glu Ala Gln Asp Ala Gln 
            100                 105                 110         


Lys Gln Gly Asn Ser Leu Ala Ala Glu Asp Trp Cys Glu Gly Ala Asp 
        115                 120                 125             


Asp Trp Gly Ser Asp Thr Glu Glu Gly Pro Ser Pro Gln Phe Thr Leu 
    130                 135                 140                 


Asp Phe Gly Asn Asp Ala Ser Ser Ala Lys Asp Val Asp Trp Thr Ala 
145                 150                 155                 160 


Arg Leu Gln Asp Leu Arg Leu Gln Asp Ala Val Leu Gly Ala Ala His 
                165                 170                 175     


Pro Val Pro Pro Gly Leu Pro Leu Phe Leu Pro Tyr Tyr Ile Cys Val 
            180                 185                 190         


Ala Asp Glu Asp Asp Tyr Arg Asp Phe Val Asn Leu Asp His Ala His 
        195                 200                 205             


Ser Leu Leu Arg Asp Tyr Gln Gln Arg Glu Gly Ile Ala Met Asp Gln 
    210                 215                 220                 


Leu Leu Ser Gln Ser Leu Pro Asn Asp Gly Asp Glu Lys Tyr Glu Lys 
225                 230                 235                 240 


Thr Ile Ile Lys Ser Gly Asp Gln Thr Phe Tyr Lys Phe Met Lys Arg 
                245                 250                 255     


Ile Ala Ala Cys Gln Glu Gln Ile Leu Arg Tyr Ser Trp Ser Gly Glu 
            260                 265                 270         


Pro Leu Phe Leu Thr Cys Pro Thr Ser Glu Val Thr Glu Leu Pro Ala 
        275                 280                 285             


Cys Ser Gln Cys Gly Gly Gln Arg Ile Phe Glu Phe Gln Leu Met Pro 
    290                 295                 300                 


Ala Leu Val Ser Met Leu Lys Ser Ala Asn Leu Gly Leu Ser Val Glu 
305                 310                 315                 320 


Phe Gly Thr Ile Leu Val Tyr Thr Cys Glu Lys Ser Cys Trp Pro Pro 
                325                 330                 335     


Asn His Gln Thr Pro Met Glu Glu Phe Cys Ile Ile Gln Glu Asp Pro 
            340                 345                 350         


Asp Glu Leu Leu Phe Lys 
        355             


<210> 4799
<211> 592
<212> PRT
<213> Homo sapiens

<400> 4799
Met Ala Ser Val Val Val Lys Thr Ile Trp Gln Ser Lys Glu Ile His 
1               5                   10                  15      


Glu Ala Gly Asp Thr Pro Thr Gly Val Glu Ser Cys Ser Gln Leu Val 
            20                  25                  30          


Pro Glu Ala Pro Arg Arg Val Thr Ser Arg Ala Lys Gly Ile Pro Lys 
        35                  40                  45              


Lys Lys Lys Ala Val Ser Phe His Gly Val Glu Pro Gln Met Ser His 
    50                  55                  60                  


Gln Pro Met His Trp Cys Leu Asn Leu Lys Arg Ser Ser Ala Cys Thr 
65                  70                  75                  80  


Asn Val Ser Leu Leu Asn Leu Ala Ala Met Glu Pro Thr Asp Ser Thr 
                85                  90                  95      


Gly Thr Asp Ser Thr Val Glu Asp Leu Ser Gly Gln Leu Thr Leu Ala 
            100                 105                 110         


Gly Pro Pro Ala Ser Pro Thr Leu Pro Trp Asp Pro Asp Asp Ala Asp 
        115                 120                 125             


Ile Thr Glu Ile Leu Ser Gly Val Asn Ser Gly Leu Val Arg Ala Lys 
    130                 135                 140                 


Asp Ser Ile Thr Ser Leu Lys Glu Lys Thr Asn Arg Val Asn Gln His 
145                 150                 155                 160 


Val Gln Ser Leu Gln Ser Glu Cys Ser Val Leu Ser Glu Asn Leu Glu 
                165                 170                 175     


Arg Arg Arg Gln Glu Ala Glu Glu Leu Glu Gly Tyr Cys Ile Gln Leu 
            180                 185                 190         


Lys Glu Asn Cys Trp Lys Val Thr Arg Ser Val Glu Asp Ala Glu Ile 
        195                 200                 205             


Lys Thr Asn Val Leu Lys Gln Asn Ser Ala Leu Leu Glu Glu Lys Leu 
    210                 215                 220                 


Arg Tyr Leu Gln Gln Gln Leu Gln Asp Glu Thr Pro Arg Arg Gln Glu 
225                 230                 235                 240 


Ala Glu Leu Gln Glu Pro Glu Glu Lys Gln Glu Pro Glu Glu Lys Gln 
                245                 250                 255     


Glu Pro Glu Glu Lys Gln Lys Pro Glu Ala Gly Leu Ser Trp Asn Ser 
            260                 265                 270         


Leu Gly Pro Ala Ala Thr Ser Gln Gly Cys Pro Gly Pro Pro Gly Ser 
        275                 280                 285             


Pro Asp Lys Pro Ser Arg Pro His Gly Leu Val Pro Ala Gly Trp Gly 
    290                 295                 300                 


Met Gly Pro Arg Ala Gly Glu Gly Pro Tyr Val Ser Glu Gln Glu Leu 
305                 310                 315                 320 


Gln Lys Leu Phe Thr Gly Ile Glu Glu Leu Arg Arg Glu Val Ser Ser 
                325                 330                 335     


Leu Thr Ala Arg Trp His Gln Glu Glu Gly Ala Val Gln Glu Ala Leu 
            340                 345                 350         


Arg Leu Leu Gly Gly Leu Gly Gly Arg Val Asp Gly Phe Leu Gly Gln 
        355                 360                 365             


Trp Glu Arg Ala Gln Arg Glu Gln Ala Gln Thr Ala Arg Asp Leu Gln 
    370                 375                 380                 


Glu Leu Arg Gly Arg Ala Asp Glu Leu Cys Thr Met Val Glu Arg Ser 
385                 390                 395                 400 


Ala Val Ser Val Ala Ser Leu Arg Ser Glu Leu Glu Gly Leu Gly Pro 
                405                 410                 415     


Leu Lys Pro Ile Leu Glu Glu Phe Gly Arg Gln Phe Gln Asn Ser Arg 
            420                 425                 430         


Arg Gly Pro Asp Leu Ser Met Asn Leu Asp Arg Ser His Gln Gly Asn 
        435                 440                 445             


Cys Ala Arg Cys Ala Ser Gln Gly Ser Gln Leu Ser Thr Glu Ser Leu 
    450                 455                 460                 


Gln Gln Leu Leu Asp Arg Ala Leu Thr Ser Leu Val Asp Glu Val Lys 
465                 470                 475                 480 


Gln Arg Gly Leu Thr Pro Ala Cys Pro Ser Cys Gln Arg Leu His Lys 
                485                 490                 495     


Lys Ile Leu Glu Leu Glu Arg Gln Ala Leu Ala Lys His Val Arg Ala 
            500                 505                 510         


Glu Ala Leu Ser Ser Thr Leu Arg Leu Ala Gln Asp Glu Ala Leu Arg 
        515                 520                 525             


Ala Lys Asn Leu Leu Leu Thr Asp Lys Met Lys Pro Glu Glu Lys Met 
    530                 535                 540                 


Ala Thr Leu Asp His Leu His Leu Lys Met Cys Ser Leu His Asp His 
545                 550                 555                 560 


Leu Ser Asn Leu Pro Leu Glu Gly Ser Thr Gly Thr Met Gly Gly Gly 
                565                 570                 575     


Ser Ser Ala Gly Thr Pro Pro Lys Gln Gly Gly Ser Ala Pro Glu Gln 
            580                 585                 590         


<210> 4800
<211> 846
<212> PRT
<213> Homo sapiens

<400> 4800
Met Ser Ser Ser His Phe Ala Ser Arg His Arg Lys Asp Ile Ser Thr 
1               5                   10                  15      


Glu Met Ile Arg Thr Lys Ile Ala His Arg Lys Ser Leu Ser Gln Lys 
            20                  25                  30          


Glu Asn Arg His Lys Glu Tyr Glu Arg Asn Arg His Phe Gly Leu Lys 
        35                  40                  45              


Asp Val Asn Ile Pro Thr Leu Glu Gly Arg Ile Leu Val Glu Leu Asp 
    50                  55                  60                  


Glu Thr Ser Gln Gly Leu Val Pro Glu Lys Thr Asn Val Lys Pro Arg 
65                  70                  75                  80  


Ala Met Lys Thr Ile Leu Gly Asp Gln Arg Lys Gln Met Leu Gln Lys 
                85                  90                  95      


Tyr Lys Glu Glu Lys Gln Leu Gln Lys Leu Lys Glu Gln Arg Glu Lys 
            100                 105                 110         


Ala Lys Arg Gly Ile Phe Lys Val Gly Arg Tyr Arg Pro Asp Met Pro 
        115                 120                 125             


Cys Phe Leu Leu Ser Asn Gln Asn Ala Val Lys Ala Glu Pro Lys Lys 
    130                 135                 140                 


Ala Ile Pro Ser Ser Val Arg Ile Thr Arg Ser Lys Ala Lys Asp Gln 
145                 150                 155                 160 


Met Glu Gln Thr Lys Ile Asp Asn Glu Ser Asp Val Arg Ala Ile Arg 
                165                 170                 175     


Pro Gly Pro Arg Gln Thr Ser Glu Lys Lys Val Ser Asp Lys Glu Lys 
            180                 185                 190         


Lys Val Val Gln Pro Val Met Pro Thr Ser Leu Arg Met Thr Arg Ser 
        195                 200                 205             


Ala Thr Gln Ala Ala Lys Gln Val Pro Arg Thr Val Ser Ser Thr Thr 
    210                 215                 220                 


Ala Arg Lys Pro Val Thr Arg Ala Ala Asn Glu Asn Glu Pro Glu Gly 
225                 230                 235                 240 


Lys Val Pro Ser Lys Gly Arg Pro Ala Lys Asn Val Glu Thr Lys Pro 
                245                 250                 255     


Asp Lys Gly Ile Ser Cys Lys Val Asp Ser Glu Glu Asn Thr Leu Asn 
            260                 265                 270         


Ser Gln Thr Asn Ala Thr Ser Gly Met Asn Pro Asp Gly Val Leu Ser 
        275                 280                 285             


Lys Met Glu Asn Leu Pro Glu Ile Asn Thr Ala Lys Ile Lys Gly Lys 
    290                 295                 300                 


Asn Ser Phe Ala Pro Lys Asp Phe Met Phe Gln Pro Leu Asp Gly Leu 
305                 310                 315                 320 


Lys Thr Tyr Gln Val Thr Pro Met Thr Pro Arg Ser Ala Asn Ala Phe 
                325                 330                 335     


Leu Thr Pro Ser Tyr Thr Trp Thr Pro Leu Lys Thr Glu Val Asp Glu 
            340                 345                 350         


Ser Gln Ala Thr Lys Glu Ile Leu Ala Gln Lys Cys Lys Thr Tyr Ser 
        355                 360                 365             


Thr Lys Thr Ile Gln Gln Asp Ser Asn Lys Leu Pro Cys Pro Leu Gly 
    370                 375                 380                 


Pro Leu Thr Val Trp His Glu Glu His Val Leu Asn Lys Asn Glu Ala 
385                 390                 395                 400 


Thr Thr Lys Asn Leu Asn Gly Leu Pro Ile Lys Glu Val Pro Ser Leu 
                405                 410                 415     


Glu Arg Asn Glu Gly Arg Ile Ala Gln Pro His His Gly Val Pro Tyr 
            420                 425                 430         


Phe Arg Asn Ile Leu Gln Ser Glu Thr Glu Lys Leu Thr Ser His Cys 
        435                 440                 445             


Phe Glu Trp Asp Arg Lys Leu Glu Leu Asp Ile Pro Asp Asp Ala Lys 
    450                 455                 460                 


Asp Leu Ile Arg Thr Ala Val Gly Gln Thr Arg Leu Leu Met Lys Glu 
465                 470                 475                 480 


Arg Phe Lys Gln Phe Glu Gly Leu Val Asp Asp Cys Glu Tyr Lys Arg 
                485                 490                 495     


Gly Ile Lys Glu Thr Thr Cys Thr Asp Leu Asp Gly Phe Trp Asp Met 
            500                 505                 510         


Val Ser Phe Gln Ile Glu Asp Val Ile His Lys Phe Asn Asn Leu Ile 
        515                 520                 525             


Lys Leu Glu Glu Ser Gly Trp Gln Val Asn Asn Asn Met Asn His Asn 
    530                 535                 540                 


Met Asn Lys Asn Val Phe Arg Lys Lys Val Val Ser Gly Ile Ala Ser 
545                 550                 555                 560 


Lys Pro Lys Gln Asp Asp Ala Gly Arg Ile Ala Ala Arg Asn Arg Leu 
                565                 570                 575     


Ala Ala Ile Lys Asn Ala Met Arg Glu Arg Ile Arg Gln Glu Glu Cys 
            580                 585                 590         


Ala Glu Thr Ala Val Ser Val Ile Pro Lys Glu Val Asp Lys Ile Val 
        595                 600                 605             


Phe Asp Ala Gly Phe Phe Arg Val Glu Ser Pro Val Lys Leu Phe Ser 
    610                 615                 620                 


Gly Leu Ser Val Ser Ser Glu Gly Pro Ser Gln Arg Leu Gly Thr Pro 
625                 630                 635                 640 


Lys Ser Val Asn Lys Ala Val Ser Gln Ser Arg Asn Glu Met Gly Ile 
                645                 650                 655     


Pro Gln Gln Thr Thr Ser Pro Glu Asn Ala Gly Pro Gln Asn Thr Lys 
            660                 665                 670         


Ser Glu His Val Lys Lys Thr Leu Phe Leu Ser Ile Pro Glu Ser Arg 
        675                 680                 685             


Ser Ser Ile Glu Asp Ala Gln Cys Pro Gly Leu Pro Asp Leu Ile Glu 
    690                 695                 700                 


Glu Asn His Val Val Asn Lys Thr Asp Leu Lys Val Asp Cys Leu Ser 
705                 710                 715                 720 


Ser Glu Arg Met Ser Leu Pro Leu Leu Ala Gly Gly Val Ala Asp Asp 
                725                 730                 735     


Ile Asn Thr Asn Lys Lys Glu Gly Ile Ser Asp Val Val Glu Gly Met 
            740                 745                 750         


Glu Leu Asn Ser Ser Ile Thr Ser Gln Asp Val Leu Met Ser Ser Pro 
        755                 760                 765             


Glu Lys Asn Thr Ala Ser Gln Asn Ser Ile Leu Glu Glu Gly Glu Thr 
    770                 775                 780                 


Lys Ile Ser Gln Ser Glu Leu Phe Asp Asn Lys Ser Leu Thr Thr Glu 
785                 790                 795                 800 


Cys His Leu Leu Asp Ser Pro Gly Leu Asn Cys Ser Asn Pro Phe Thr 
                805                 810                 815     


Gln Leu Glu Arg Arg His Gln Glu His Ala Arg His Ile Ser Phe Gly 
            820                 825                 830         


Gly Asn Leu Ile Thr Phe Ser Pro Leu Gln Pro Gly Glu Phe 
        835                 840                 845     


<210> 4801
<211> 375
<212> PRT
<213> Homo sapiens

<400> 4801
Met Ala Ser Ala Pro Trp Pro Glu Arg Val Pro Arg Leu Leu Ala Pro 
1               5                   10                  15      


Arg Leu Pro Ser Tyr Pro Pro Pro Pro Pro Thr Val Gly Leu Arg Ser 
            20                  25                  30          


Met Glu Gln Glu Glu Thr Tyr Leu Glu Leu Tyr Leu Asp Gln Cys Ala 
        35                  40                  45              


Ala Gln Asp Gly Leu Ala Pro Pro Arg Ser Pro Leu Phe Ser Pro Val 
    50                  55                  60                  


Val Pro Tyr Asp Met Tyr Ile Leu Asn Ala Ser Asn Pro Asp Thr Ala 
65                  70                  75                  80  


Phe Asn Ser Asn Pro Glu Val Lys Glu Thr Ser Gly Asp Phe Ser Ser 
                85                  90                  95      


Val Asp Leu Ser Phe Leu Pro Asp Glu Val Thr Gln Glu Asn Lys Asp 
            100                 105                 110         


Gln Pro Val Ile Ser Lys His Glu Thr Glu Glu Asn Ser Glu Ser Gln 
        115                 120                 125             


Ser Pro Gln Ser Arg Leu Pro Ser Pro Ser Glu Gln Asp Val Gly Leu 
    130                 135                 140                 


Gly Leu Asn Ser Ser Ser Leu Ser Asn Ser His Ser Gln Leu His Pro 
145                 150                 155                 160 


Gly Asp Thr Asp Ser Val Gln Pro Ser Pro Glu Lys Pro Asn Ser Asp 
                165                 170                 175     


Ser Leu Ser Leu Ala Ser Ile Thr Pro Met Thr Pro Met Thr Pro Ile 
            180                 185                 190         


Ser Glu Cys Cys Gly Ile Val Pro Gln Leu Gln Asn Ile Val Ser Thr 
        195                 200                 205             


Val Asn Leu Ala Cys Lys Leu Asp Leu Lys Lys Ile Ala Leu His Ala 
    210                 215                 220                 


Lys Asn Ala Glu Tyr Asn Pro Lys Arg Phe Ala Ala Val Ile Met Arg 
225                 230                 235                 240 


Ile Arg Glu Pro Arg Thr Thr Ala Leu Ile Phe Ser Ser Gly Lys Met 
                245                 250                 255     


Val Cys Thr Gly Ala Lys Ser Glu Glu Gln Ser Arg Leu Ala Ala Arg 
            260                 265                 270         


Lys Tyr Ala Arg Val Val Gln Lys Leu Gly Phe Pro Ala Arg Phe Leu 
        275                 280                 285             


Asp Phe Lys Ile Gln Asn Met Val Gly Ser Cys Asp Val Arg Phe Pro 
    290                 295                 300                 


Ile Arg Leu Glu Gly Leu Val Leu Thr His Gln Gln Phe Ser Ser Tyr 
305                 310                 315                 320 


Glu Pro Glu Leu Phe Pro Gly Leu Ile Tyr Arg Met Val Lys Pro Arg 
                325                 330                 335     


Ile Val Leu Leu Ile Phe Val Ser Gly Lys Val Val Leu Thr Gly Ala 
            340                 345                 350         


Lys Glu Arg Ser Glu Ile Tyr Glu Ala Phe Glu Asn Ile Tyr Pro Ile 
        355                 360                 365             


Leu Lys Gly Phe Lys Lys Ala 
    370                 375 


<210> 4802
<211> 210
<212> PRT
<213> Homo sapiens

<400> 4802
Met Gln Ala Glu Gly Gln Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Gln Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Met Ser Val Arg Asp Gln Asp Arg Glu Gly 
    130                 135                 140                 


Ala Gly Arg Met Arg Val Val Gly Trp Gly Leu Gly Ser Ala Ser Pro 
145                 150                 155                 160 


Glu Gly Gln Lys Ala Arg Asp Leu Arg Thr Pro Lys His Lys Val Ser 
                165                 170                 175     


Glu Gln Arg Pro Gly Thr Pro Gly Pro Pro Pro Pro Glu Gly Ala Gln 
            180                 185                 190         


Gly Asp Gly Cys Arg Gly Val Ala Phe Asn Val Met Phe Ser Ala Pro 
        195                 200                 205             


His Ile 
    210 


<210> 4803
<211> 193
<212> PRT
<213> Homo sapiens

<400> 4803
Met Val Val Leu Arg Ala Gly Lys Lys Thr Phe Leu Pro Pro Leu Cys 
1               5                   10                  15      


Arg Ala Phe Ala Cys Arg Gly Cys Gln Leu Ala Pro Glu Arg Gly Ala 
            20                  25                  30          


Glu Arg Arg Asp Thr Ala Pro Ser Gly Val Ser Arg Phe Cys Pro Pro 
        35                  40                  45              


Arg Lys Ser Cys His Asp Trp Ile Gly Pro Pro Asp Lys Tyr Ser Asn 
    50                  55                  60                  


Leu Arg Pro Val His Phe Tyr Ile Pro Glu Asn Glu Ser Pro Leu Glu 
65                  70                  75                  80  


Gln Lys Leu Arg Lys Leu Arg Gln Glu Thr Gln Glu Trp Asn Gln Gln 
                85                  90                  95      


Phe Trp Ala Asn Gln Asn Leu Thr Phe Ser Lys Glu Lys Glu Glu Phe 
            100                 105                 110         


Ile His Ser Arg Leu Lys Thr Lys Gly Leu Gly Leu Arg Thr Glu Ser 
        115                 120                 125             


Gly Gln Lys Ala Thr Leu Asn Ala Glu Glu Met Ala Asp Phe Tyr Lys 
    130                 135                 140                 


Glu Phe Leu Ser Lys Asn Phe Gln Lys His Met Tyr Tyr Asn Arg Asp 
145                 150                 155                 160 


Trp Tyr Lys Arg Asn Phe Ala Ile Thr Phe Phe Met Gly Lys Val Ala 
                165                 170                 175     


Leu Glu Arg Ile Trp Asn Lys Leu Lys Gln Lys Gln Lys Lys Arg Ser 
            180                 185                 190         


Asn 
    


<210> 4804
<211> 460
<212> PRT
<213> Homo sapiens

<400> 4804
Met Ala Asn Asp Pro Leu Glu Gly Phe His Glu Val Asn Leu Ala Ser 
1               5                   10                  15      


Pro Thr Ser Pro Asp Leu Leu Gly Val Tyr Glu Ser Gly Thr Gln Glu 
            20                  25                  30          


Gln Thr Thr Ser Pro Ser Val Ile Tyr Arg Pro His Pro Ser Ala Leu 
        35                  40                  45              


Ser Ser Val Pro Ile Gln Ala Asn Ala Leu Asp Val Ser Glu Leu Pro 
    50                  55                  60                  


Thr Gln Pro Val Tyr Ser Ser Pro Arg Arg Leu Asn Cys Ala Glu Ile 
65                  70                  75                  80  


Ser Ser Ile Ser Phe His Val Thr Asp Pro Ala Pro Cys Ser Thr Ser 
                85                  90                  95      


Gly Val Thr Ala Gly Leu Thr Lys Leu Thr Thr Arg Lys Asp Asn Tyr 
            100                 105                 110         


Asn Ala Glu Arg Glu Phe Leu Gln Gly Ala Thr Ile Thr Glu Ala Cys 
        115                 120                 125             


Asp Gly Ser Asp Asp Ile Phe Gly Leu Ser Thr Asp Ser Leu Ser Arg 
    130                 135                 140                 


Leu Arg Ser Pro Ser Val Leu Glu Val Arg Glu Lys Gly Tyr Glu Arg 
145                 150                 155                 160 


Leu Lys Glu Glu Leu Ala Lys Ala Gln Arg Glu Leu Lys Leu Lys Asp 
                165                 170                 175     


Glu Glu Cys Glu Arg Leu Ser Lys Val Arg Asp Gln Leu Gly Gln Glu 
            180                 185                 190         


Leu Glu Glu Leu Thr Ala Ser Leu Phe Glu Glu Ala His Lys Met Val 
        195                 200                 205             


Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu Lys Glu 
    210                 215                 220                 


Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala Leu Lys 
225                 230                 235                 240 


Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu Pro Leu 
                245                 250                 255     


Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn Lys Ser 
            260                 265                 270         


Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val Ile Gln 
        275                 280                 285             


Pro Ile Val Lys Asp Cys Lys Glu Ala Asp Leu Ser Leu Tyr Asn Glu 
    290                 295                 300                 


Phe Arg Leu Trp Lys Asp Glu Pro Thr Met Asp Arg Thr Cys Pro Phe 
305                 310                 315                 320 


Leu Asp Lys Ile Tyr Gln Glu Asp Ile Phe Pro Cys Leu Thr Phe Ser 
                325                 330                 335     


Lys Ser Glu Leu Ala Ser Ala Val Leu Glu Ala Val Glu Asn Asn Thr 
            340                 345                 350         


Leu Ser Ile Glu Pro Val Gly Leu Gln Pro Ile Arg Phe Val Lys Ala 
        355                 360                 365             


Ser Ala Val Glu Cys Gly Gly Pro Lys Lys Cys Ala Leu Thr Gly Gln 
    370                 375                 380                 


Ser Lys Ser Cys Lys His Arg Ile Lys Leu Gly Asp Ser Ser Asn Tyr 
385                 390                 395                 400 


Tyr Tyr Ile Ser Pro Phe Cys Arg Tyr Arg Ile Thr Ser Val Cys Asn 
                405                 410                 415     


Phe Phe Thr Tyr Ile Arg Tyr Ile Gln Gln Gly Leu Val Lys Gln Gln 
            420                 425                 430         


Asp Val Asp Gln Met Phe Trp Glu Val Met Gln Leu Arg Lys Glu Met 
        435                 440                 445             


Ser Leu Ala Lys Leu Gly Tyr Phe Lys Glu Glu Leu 
    450                 455                 460 


<210> 4805
<211> 326
<212> PRT
<213> Homo sapiens

<400> 4805
Met Ala Thr Leu Val Glu Leu Pro Asp Ser Val Leu Leu Glu Ile Phe 
1               5                   10                  15      


Ser Tyr Leu Pro Val Arg Asp Arg Ile Arg Ile Ser Arg Val Cys His 
            20                  25                  30          


Arg Trp Lys Arg Leu Val Asp Asp Arg Trp Leu Trp Arg His Val Asp 
        35                  40                  45              


Leu Thr Leu Tyr Thr Met Arg Pro Lys Val Met Trp His Leu Leu Arg 
    50                  55                  60                  


Arg Tyr Met Ala Ser Arg Leu His Ser Leu Arg Met Gly Gly Tyr Leu 
65                  70                  75                  80  


Phe Ser Gly Ser Gln Ala Pro Gln Leu Ser Pro Ala Leu Leu Arg Ala 
                85                  90                  95      


Leu Gly Gln Lys Cys Pro Asn Leu Lys Arg Leu Cys Leu His Val Ala 
            100                 105                 110         


Asp Leu Ser Met Val Pro Ile Thr Ser Leu Pro Ser Thr Leu Arg Thr 
        115                 120                 125             


Leu Glu Leu His Ser Cys Glu Ile Ser Met Ala Trp Leu His Lys Gln 
    130                 135                 140                 


Gln Asp Pro Thr Val Leu Pro Leu Leu Glu Cys Ile Val Leu Asp Arg 
145                 150                 155                 160 


Val Pro Ala Phe Arg Asp Glu His Leu Gln Gly Leu Thr Arg Phe Arg 
                165                 170                 175     


Ala Leu Arg Ser Leu Val Leu Gly Gly Thr Tyr Arg Val Thr Glu Thr 
            180                 185                 190         


Gly Leu Asp Ala Gly Leu Gln Glu Leu Ser Tyr Leu Gln Arg Leu Glu 
        195                 200                 205             


Val Leu Gly Cys Thr Leu Ser Ala Asp Ser Thr Leu Leu Ala Ile Ser 
    210                 215                 220                 


Arg His Leu Arg Asp Val Arg Lys Ile Arg Leu Thr Val Arg Gly Leu 
225                 230                 235                 240 


Ser Ala Pro Gly Leu Ala Val Leu Glu Gly Met Pro Ala Leu Glu Ser 
                245                 250                 255     


Leu Cys Leu Gln Gly Pro Leu Val Thr Pro Glu Met Pro Ser Pro Thr 
            260                 265                 270         


Glu Ile Leu Ser Ser Cys Leu Thr Met Pro Lys Leu Arg Val Leu Glu 
        275                 280                 285             


Leu Gln Gly Leu Gly Trp Glu Gly Gln Glu Ala Glu Lys Ile Leu Cys 
    290                 295                 300                 


Lys Gly Leu Pro His Cys Met Val Ile Val Arg Ala Cys Pro Lys Glu 
305                 310                 315                 320 


Ser Met Asp Trp Trp Met 
                325     


<210> 4806
<211> 1029
<212> PRT
<213> Homo sapiens

<400> 4806
Met Ala Ser Glu Ala Val Lys Val Val Val Arg Cys Arg Pro Met Asn 
1               5                   10                  15      


Gln Arg Glu Arg Glu Leu Arg Cys Gln Pro Val Val Thr Val Asp Cys 
            20                  25                  30          


Ala Arg Ala Gln Cys Cys Ile Gln Asn Pro Gly Ala Ala Asp Glu Pro 
        35                  40                  45              


Pro Lys Gln Phe Thr Phe Asp Gly Ala Tyr His Val Asp His Val Thr 
    50                  55                  60                  


Glu Gln Ile Tyr Asn Glu Ile Ala Tyr Pro Leu Val Glu Gly Val Thr 
65                  70                  75                  80  


Glu Gly Tyr Asn Gly Thr Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly 
                85                  90                  95      


Lys Ser Phe Thr Met Gln Gly Leu Pro Asp Pro Pro Ser Gln Arg Gly 
            100                 105                 110         


Ile Ile Pro Arg Ala Phe Glu His Val Phe Glu Ser Val Gln Cys Ala 
        115                 120                 125             


Glu Asn Thr Lys Phe Leu Val Arg Ala Ser Tyr Leu Glu Ile Tyr Asn 
    130                 135                 140                 


Glu Asp Val Arg Asp Leu Leu Gly Ala Asp Thr Lys Gln Lys Leu Glu 
145                 150                 155                 160 


Leu Lys Glu His Pro Glu Lys Gly Val Tyr Val Lys Gly Leu Ser Met 
                165                 170                 175     


His Thr Val His Ser Val Ala Gln Cys Glu His Ile Met Glu Thr Gly 
            180                 185                 190         


Trp Lys Asn Arg Ser Val Gly Tyr Thr Leu Met Asn Lys Asp Ser Ser 
        195                 200                 205             


Arg Ser His Ser Ile Phe Thr Ile Ser Ile Glu Met Ser Ala Val Asp 
    210                 215                 220                 


Glu Arg Gly Lys Asp His Leu Arg Ala Gly Lys Leu Asn Leu Val Asp 
225                 230                 235                 240 


Leu Ala Gly Ser Glu Arg Gln Ser Lys Thr Gly Ala Thr Gly Glu Arg 
                245                 250                 255     


Leu Lys Glu Ala Thr Lys Ile Asn Leu Ser Leu Ser Ala Leu Gly Asn 
            260                 265                 270         


Val Ile Ser Ala Leu Val Asp Gly Arg Cys Lys His Val Pro Tyr Arg 
        275                 280                 285             


Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Thr 
    290                 295                 300                 


Lys Thr Leu Met Val Ala Cys Leu Ser Pro Ala Asp Asn Asn Tyr Asp 
305                 310                 315                 320 


Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asn Arg Ala Lys Asn Ile Arg 
                325                 330                 335     


Asn Lys Pro Arg Ile Asn Glu Asp Pro Lys Asp Ala Leu Leu Arg Glu 
            340                 345                 350         


Tyr Gln Glu Glu Ile Lys Lys Leu Lys Ala Ile Leu Thr Gln Gln Met 
        355                 360                 365             


Ser Pro Ser Ser Leu Ser Ala Leu Leu Ser Arg Gln Val Pro Pro Asp 
    370                 375                 380                 


Pro Val Gln Val Glu Glu Lys Leu Leu Pro Gln Pro Val Ile Gln His 
385                 390                 395                 400 


Asp Val Glu Ala Glu Lys Gln Leu Ile Arg Glu Glu Tyr Glu Glu Arg 
                405                 410                 415     


Leu Ala Arg Leu Lys Ala Asp Tyr Lys Ala Glu Gln Glu Ser Arg Ala 
            420                 425                 430         


Arg Leu Glu Glu Asp Ile Thr Ala Met Arg Asn Ser Tyr Asp Val Arg 
        435                 440                 445             


Leu Ser Thr Leu Glu Glu Asn Leu Arg Lys Glu Thr Glu Ala Val Leu 
    450                 455                 460                 


Gln Val Gly Val Leu Tyr Lys Ala Glu Val Met Ser Arg Ala Glu Phe 
465                 470                 475                 480 


Ala Ser Ser Ala Glu Tyr Pro Pro Ala Phe Gln Tyr Glu Thr Val Val 
                485                 490                 495     


Lys Pro Lys Val Phe Ser Thr Thr Asp Thr Leu Pro Ser Asp Asp Val 
            500                 505                 510         


Ser Lys Thr Gln Val Ser Ser Arg Phe Ala Glu Leu Pro Lys Val Glu 
        515                 520                 525             


Pro Ser Lys Ser Glu Ile Ser Leu Gly Ser Ser Glu Ser Ser Ser Leu 
    530                 535                 540                 


Glu Glu Thr Ser Val Ser Glu Ala Phe Pro Gly Pro Glu Glu Pro Ser 
545                 550                 555                 560 


Asn Val Glu Val Ser Met Pro Thr Glu Glu Ser Arg Ser Arg Tyr Phe 
                565                 570                 575     


Leu Asp Glu Cys Leu Gly Gln Glu Ala Ala Gly His Leu Leu Gly Glu 
            580                 585                 590         


Gln Asn Tyr Leu Pro Gln Glu Glu Pro Gln Glu Val Pro Leu Gln Gly 
        595                 600                 605             


Leu Leu Gly Leu Gln Asp Pro Phe Ala Glu Val Glu Ala Lys Leu Ala 
    610                 615                 620                 


Arg Leu Ser Ser Thr Val Ala Arg Thr Asp Ala Pro Gln Ala Asp Val 
625                 630                 635                 640 


Pro Lys Val Pro Val Gln Val Pro Ala Pro Thr Asp Leu Leu Glu Pro 
                645                 650                 655     


Ser Asp Ala Arg Pro Glu Ala Glu Ala Ala Asp Asp Phe Pro Pro Arg 
            660                 665                 670         


Pro Glu Val Asp Leu Ala Ser Glu Val Ala Leu Glu Val Val Arg Thr 
        675                 680                 685             


Ala Glu Pro Gly Val Trp Leu Glu Ala Gln Ala Pro Val Ala Leu Val 
    690                 695                 700                 


Ala Gln Pro Glu Pro Leu Pro Ala Thr Ala Gly Val Lys Arg Glu Ser 
705                 710                 715                 720 


Val Gly Met Glu Val Ala Val Leu Thr Asp Asp Pro Leu Pro Val Val 
                725                 730                 735     


Asp Gln Gln Gln Val Leu Ala Arg Leu Gln Leu Leu Glu Gln Gln Val 
            740                 745                 750         


Val Gly Gly Glu Gln Ala Lys Asn Lys Asp Leu Lys Glu Lys His Lys 
        755                 760                 765             


Arg Arg Lys Arg Tyr Ala Asp Glu Arg Arg Lys Gln Leu Val Ala Ala 
    770                 775                 780                 


Leu Gln Asn Ser Asp Glu Asp Ser Gly Asp Trp Val Leu Leu Asn Val 
785                 790                 795                 800 


Tyr Asp Ser Ile Gln Glu Glu Val Arg Ala Lys Ser Lys Leu Leu Glu 
                805                 810                 815     


Lys Met Gln Arg Lys Leu Arg Ala Ala Glu Val Glu Ile Lys Asp Leu 
            820                 825                 830         


Gln Ser Glu Phe Gln Leu Glu Lys Ile Asp Tyr Leu Ala Thr Ile Arg 
        835                 840                 845             


Arg Gln Glu Arg Asp Ser Met Leu Leu Gln Gln Leu Leu Glu Gln Val 
    850                 855                 860                 


Gln Pro Leu Ile Arg Arg Asp Cys Asn Tyr Ser Asn Leu Glu Lys Ile 
865                 870                 875                 880 


Leu Arg Glu Ser Cys Trp Asp Glu Asp Asn Gly Phe Trp Lys Ile Pro 
                885                 890                 895     


His Pro Val Ile Thr Lys Thr Ser Leu Pro Val Ala Val Ser Thr Gly 
            900                 905                 910         


Pro Gln Asn Lys Pro Ala Arg Lys Thr Ser Ala Ala Asp Asn Gly Glu 
        915                 920                 925             


Pro Asn Met Glu Asp Asp Arg Tyr Arg Leu Met Leu Ser Arg Ser Asn 
    930                 935                 940                 


Ser Glu Asn Ile Ala Ser Asn Tyr Phe Arg Ser Lys Arg Ala Ser Gln 
945                 950                 955                 960 


Ile Leu Ser Thr Asp Ala Arg Lys Ser Leu Thr His His Asn Ser Pro 
                965                 970                 975     


Pro Gly Leu Ser Cys Pro Leu Ser Asn Asn Ser Ala Ile Pro Pro Thr 
            980                 985                 990         


Gln Ala Pro Glu Met Pro Gln Pro  Arg Pro Phe Arg Leu  Glu Ser Leu 
        995                 1000                 1005             


Asp Ile  Pro Phe Thr Lys Ala  Lys Arg Lys Lys Ser  Lys Ser Asn 
    1010                 1015                 1020             


Phe Gly  Ser Glu Pro Leu 
    1025                 


<210> 4807
<211> 138
<212> PRT
<213> Homo sapiens

<400> 4807
Met Ile Leu Gln Gln Pro Leu Gln Arg Gly Pro Gln Gly Gly Ala Gln 
1               5                   10                  15      


Arg Leu Pro Arg Ala Ala Leu Gly Val Thr Trp Gly Leu Asp Ala Ser 
            20                  25                  30          


Ser Pro Leu Arg Gly Ala Val Pro Met Ser Thr Lys Arg Arg Leu Glu 
        35                  40                  45              


Glu Glu Gln Glu Pro Leu Arg Lys Gln Phe Leu Ser Glu Glu Asn Met 
    50                  55                  60                  


Ala Thr His Phe Ser Gln Leu Ser Leu His Asn Asp His Pro Tyr Cys 
65                  70                  75                  80  


Ser Pro Pro Met Thr Phe Ser Pro Ala Leu Pro Pro Leu Arg Ser Pro 
                85                  90                  95      


Cys Ser Glu Leu Leu Leu Trp Arg Tyr Pro Gly Ser Leu Ile Pro Glu 
            100                 105                 110         


Ala Leu Arg Leu Leu Arg Leu Gly Asp Thr Pro Ser Pro Pro Tyr Pro 
        115                 120                 125             


Ala Thr Pro Ala Gly Asp Ile Met Glu Leu 
    130                 135             


<210> 4808
<211> 190
<212> PRT
<213> Homo sapiens

<400> 4808
Met Phe Gln Val Pro Asp Ser Glu Gly Gly Arg Ala Gly Ser Arg Ala 
1               5                   10                  15      


Met Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe Gly Ser Pro Glu 
            20                  25                  30          


Glu Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ala Ser Asn Ile Phe 
        35                  40                  45              


Gly Pro Thr Glu Glu Pro Gln Asn Ile Pro Lys Arg Thr Asn Pro Pro 
    50                  55                  60                  


Gly Gly Lys Gly Ser Gly Ile Phe Asp Glu Ser Thr Pro Val Gln Thr 
65                  70                  75                  80  


Arg Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser Asp Ile Phe Gly 
                85                  90                  95      


Ser Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro Asn Lys Pro Lys 
            100                 105                 110         


Asp His Val Phe Leu Cys Glu Gly Glu Glu Pro Lys Ser Asp Leu Lys 
        115                 120                 125             


Ala Ala Arg Ser Ile Pro Ala Gly Ala Glu Pro Gly Glu Lys Gly Ser 
    130                 135                 140                 


Ala Arg Lys Ala Gly Pro Ala Lys Glu Gln Glu Pro Met Pro Thr Val 
145                 150                 155                 160 


Asp Ser His Glu Pro Arg Leu Gly Pro Arg Pro Arg Ser His Asn Lys 
                165                 170                 175     


Val Leu Asn Pro Pro Gly Gly Lys Ser Ser Ile Ser Phe Tyr 
            180                 185                 190 


<210> 4809
<211> 229
<212> PRT
<213> Homo sapiens

<400> 4809
Met Thr Cys Cys Ser Gln Val Pro Pro Arg Arg Arg Pro Ser Leu Ala 
1               5                   10                  15      


Leu Ser Pro Arg Leu Asp Cys Asn Gly Leu Asn Gly Val Pro Gly Ser 
            20                  25                  30          


Ile Trp Asp Phe Val Ser Gly Ser Phe Ser Pro Ser Pro Ser Pro Ile 
        35                  40                  45              


Leu Ser Ala Gly Pro Pro Ser Ser Ser Ser Ala Ser Pro Asn Gly Ala 
    50                  55                  60                  


Glu Leu Ala Arg Val Arg Arg Gln Leu Asp Glu Ala Lys Arg Lys Ile 
65                  70                  75                  80  


Arg Gln Trp Glu Glu Ser Trp Gln Gln Val Lys Gln Val Cys Asp Ala 
                85                  90                  95      


Trp Gln Arg Glu Ala Gln Glu Ala Lys Glu Arg Ala Arg Val Ala Asp 
            100                 105                 110         


Ser Asp Arg Gln Leu Ala Leu Gln Lys Lys Glu Glu Val Glu Ala Gln 
        115                 120                 125             


Val Lys Gln Leu Gln Glu Glu Leu Glu Gly Leu Gly Val Ala Ser Thr 
    130                 135                 140                 


Leu Pro Gly Leu Arg Gly Cys Gly Asp Ile Gly Thr Ile Pro Leu Pro 
145                 150                 155                 160 


Lys Leu His Ser Leu Gln Ser Gln Leu Arg Leu Asp Leu Glu Ala Val 
                165                 170                 175     


Asp Gly Val Ile Phe Gln Leu Arg Ala Lys Gln Cys Val Ala Cys Arg 
            180                 185                 190         


Glu Arg Ala His Gly Ala Val Leu Arg Pro Cys Gln His His Ile Leu 
        195                 200                 205             


Cys Glu Pro Cys Ala Ala Thr Ala Pro Glu Cys Pro Tyr Cys Lys Gly 
    210                 215                 220                 


Gln Pro Leu Gln Trp 
225                 


<210> 4810
<211> 1819
<212> PRT
<213> Homo sapiens

<400> 4810
Met Ala Ser Ile Thr Gln Leu Phe Asp Asp Leu Cys Glu Ala Leu Leu 
1               5                   10                  15      


Pro Ala Ala Lys Thr His Leu Gly Gln Arg Ser Val Asn Arg Lys Arg 
            20                  25                  30          


Ala Lys Arg Ser Leu Lys Lys Val Ala Tyr Asn Ala Leu Phe Thr Asn 
        35                  40                  45              


Leu Phe Gln Asp Glu Thr Gln Gln Leu Gln Pro Asp Met Ser Lys Leu 
    50                  55                  60                  


Pro Ala Arg Asn Lys Ile Leu Met Leu Ser Phe Asp Leu Arg Val Gly 
65                  70                  75                  80  


Gly Leu Gly Pro Lys Ala Asp Arg Leu Glu Glu Leu Val Glu Glu Leu 
                85                  90                  95      


Glu Ala Ala Pro Cys Cys Pro Leu Leu Glu Val Gly Ser Val Leu Asp 
            100                 105                 110         


Leu Leu Val Gln Leu Ala Gly Ser Gly Pro Pro Gln Val Leu Pro Arg 
        115                 120                 125             


Lys Arg Asp Tyr Phe Leu Asn Asn Lys His Val Gly Arg Asn Val Pro 
    130                 135                 140                 


Tyr Ser Gly Tyr Asp Cys Asp Asp Leu Ser Val Phe Glu Met Asp Val 
145                 150                 155                 160 


Gln Ser Leu Ile Ser Arg Glu Glu Cys Leu Cys His Ser Met Ile Gln 
                165                 170                 175     


Glu Thr Leu Gln Val Met Glu Ala Ala Pro Gly Thr Gly Leu Pro Thr 
            180                 185                 190         


Val Gly Leu Phe Ser Phe Gly Asp Pro Cys Gly Asp Arg Phe Glu Arg 
        195                 200                 205             


Asp Thr Arg Val Ser Leu Phe Gly Ala Leu Val His Ser Arg Thr Tyr 
    210                 215                 220                 


Asp Met Asp Val Arg Leu Gly Leu Pro Pro Val Pro Asp Asn Ala Asp 
225                 230                 235                 240 


Leu Ser Gly Leu Ala Ile Lys Val Pro Pro Ser Val Asp Gln Trp Glu 
                245                 250                 255     


Asp Glu Gly Phe Gln Ser Ala Ser Asn Leu Thr Pro Asp Ser Gln Ser 
            260                 265                 270         


Glu Pro Ser Val Thr Pro Asp Val Asp Leu Trp Glu Ala Ala Leu Thr 
        275                 280                 285             


Tyr Glu Ala Ser Lys Arg Arg Cys Trp Glu Arg Val Gly Cys Pro Pro 
    290                 295                 300                 


Gly His Arg Glu Glu Pro Tyr Leu Thr Glu Ala Gly Arg Asp Ala Phe 
305                 310                 315                 320 


Asp Lys Phe Cys Arg Leu His Gln Gly Glu Leu Gln Leu Leu Ala Gly 
                325                 330                 335     


Gly Val Leu Gln Ala Pro Gln Pro Val Leu Val Lys Glu Cys Glu Leu 
            340                 345                 350         


Val Lys Asp Val Leu Asn Val Leu Ile Gly Val Val Ser Ala Thr Phe 
        355                 360                 365             


Ser Leu Cys Gln Pro Ala Gln Ala Phe Val Val Lys Arg Gly Val His 
    370                 375                 380                 


Val Ser Gly Ala Ser Pro Glu Ser Ile Ser Ser Leu Leu Ser Glu Val 
385                 390                 395                 400 


Ala Glu Tyr Gly Thr Cys Tyr Thr Arg Leu Ser His Phe Ser Leu Gln 
                405                 410                 415     


Pro Val Leu Asp Ser Leu Tyr Ser Lys Gly Leu Val Phe Gln Ala Phe 
            420                 425                 430         


Thr Ser Gly Leu Arg Arg Tyr Leu Gln Tyr Tyr Arg Ala Cys Val Leu 
        435                 440                 445             


Ser Thr Pro Pro Thr Leu Ser Leu Leu Thr Ile Gly Phe Leu Phe Lys 
    450                 455                 460                 


Lys Leu Gly Arg Gln Leu Arg Tyr Leu Ala Glu Leu Cys Gly Val Gly 
465                 470                 475                 480 


Ala Val Leu Pro Gly Thr Cys Gly Gly Gly Pro Arg Ala Ala Phe Pro 
                485                 490                 495     


Thr Gly Val Lys Leu Leu Ser Tyr Leu Tyr Gln Glu Ala Leu His Asn 
            500                 505                 510         


Cys Ser Asn Glu His Tyr Pro Val Leu Leu Ser Leu Leu Lys Thr Ser 
        515                 520                 525             


Cys Glu Pro Tyr Thr Arg Phe Ile His Asp Trp Val Tyr Ser Gly Val 
    530                 535                 540                 


Phe Arg Asp Ala Tyr Gly Glu Phe Met Ile Gln Val Asn His Glu Tyr 
545                 550                 555                 560 


Leu Ser Phe Arg Asp Lys Leu Tyr Trp Thr His Gly Tyr Val Leu Ile 
                565                 570                 575     


Ser Lys Glu Val Glu Asp Cys Val Pro Val Phe Leu Lys His Ile Ala 
            580                 585                 590         


His Asp Ile Tyr Val Cys Gly Lys Thr Ile Asn Leu Leu Lys Leu Cys 
        595                 600                 605             


Cys Pro Arg His Tyr Leu Cys Trp Ser Asp Val Pro Val Pro Arg Ile 
    610                 615                 620                 


Ser Val Ile Phe Ser Leu Glu Glu Leu Lys Glu Ile Glu Lys Asp Cys 
625                 630                 635                 640 


Ala Val Tyr Val Gly Arg Met Glu Arg Val Ala Arg His Ser Ser Val 
                645                 650                 655     


Ser Lys Glu Glu Lys Glu Leu Arg Met Glu Ile Ala Lys Gln Glu Leu 
            660                 665                 670         


Ile Ala His Ala Arg Glu Ala Ala Ser Arg Val Leu Ser Ala Leu Ser 
        675                 680                 685             


Asp Arg Gln Met Ser Glu Arg Met Ala Leu Asp Ala Arg Lys Arg Glu 
    690                 695                 700                 


Gln Phe Gln Arg Leu Lys Glu Gln Phe Val Lys Asp Gln Glu Arg Arg 
705                 710                 715                 720 


Gln Ala Ala Arg Gln Glu Glu Leu Asp Asp Asp Phe Ser Tyr Ala Arg 
                725                 730                 735     


Glu Leu Arg Asp Arg Glu Arg Arg Leu Lys Ser Leu Glu Glu Glu Leu 
            740                 745                 750         


Glu Arg Lys Ala Arg Gln Ala Leu Val Asp His Tyr Ser Lys Leu Ser 
        755                 760                 765             


Ala Glu Ala Ala Arg Arg Glu Gln Lys Ala Leu Trp Arg Ile Gln Arg 
    770                 775                 780                 


His Arg Leu Glu Ser Ala Arg Leu Arg Phe Leu Leu Glu Asp Glu Lys 
785                 790                 795                 800 


His Ile Gln Glu Met Leu Lys Ala Val Ser Glu Ala His Gln Pro Gln 
                805                 810                 815     


Glu Pro Pro Asp Val Leu Leu Ser Val His Pro Gln Val Thr Ser Pro 
            820                 825                 830         


Gly Pro Glu His Pro Glu Gly Gly Gln Gly Cys Asp Ser Gly Ser Ala 
        835                 840                 845             


Glu Gln His Ser Pro Ala Trp Asp Gly Trp Asn Arg Pro Gly Leu Leu 
    850                 855                 860                 


Thr Pro Gln Pro Leu Lys Pro Leu Ala Val Gly Ala Gly Gly Arg Gly 
865                 870                 875                 880 


Leu Gln Gln Ala Glu Gly Ala Arg Pro Phe Ser Asp Ser Leu Ser Ile 
                885                 890                 895     


Gly Asp Phe Leu Pro Val Gly Pro Gly Ala Glu Pro Ser Val Gln Thr 
            900                 905                 910         


Gly Met Val Pro Leu Leu Glu Val Ala Leu Gln Thr Ile Asn Leu Asp 
        915                 920                 925             


Leu Pro Pro Ser Ala Pro Gly Glu Ala Pro Ala Ala Ala Ser Thr Gln 
    930                 935                 940                 


Pro Ser Arg Pro Gln Glu Tyr Asp Phe Ser Thr Val Leu Arg Pro Ala 
945                 950                 955                 960 


Val Ala Thr Ser Pro Ala Pro Gly Pro Leu Gln Ala Ala Glu Cys Ser 
                965                 970                 975     


Leu Gly Ser Ser Gly Leu Gln Leu Trp Glu Asp Ser Cys Gly Lys Met 
            980                 985                 990         


Asp Ala Cys Gly Ser Ala Ser Arg  Glu Thr Leu Leu Pro  Ser His Pro 
        995                 1000                 1005             


Pro Arg  Arg Ala Ala Leu Glu  Glu Gly Ser Ser Gln  Pro Thr Glu 
    1010                 1015                 1020             


Arg Leu  Phe Gly Gln Val Ser  Gly Gly Gly Leu Pro  Thr Gly Asp 
    1025                 1030                 1035             


Tyr Ala  Ser Glu Ile Ala Pro  Thr Arg Pro Arg Trp  Asn Thr His 
    1040                 1045                 1050             


Gly His  Val Ser Asp Ala Ser  Ile Arg Val Gly Glu  Asn Val Ser 
    1055                 1060                 1065             


Asp Val  Ala Pro Thr Gln Pro  Arg Trp Asn Thr His  Gly His Val 
    1070                 1075                 1080             


Ser Asn  Ala Ser Ile Ser Leu  Gly Glu Ser Val Ser  Asp Val Ala 
    1085                 1090                 1095             


Pro Thr  Arg Pro Arg Trp Asn  Ile His Gly His Val  Ser Asn Ala 
    1100                 1105                 1110             


Ser Ile  Arg Val Gly Glu Asn  Val Ser Asp Val Ala  Pro Thr Arg 
    1115                 1120                 1125             


Pro Arg  Trp Asn Thr His Gly  His Val Ser Asn Ala  Ser Ile Arg 
    1130                 1135                 1140             


Val Gly  Glu Asn Val Ser Asp  Val Ala Pro Thr Arg  Pro Arg Trp 
    1145                 1150                 1155             


Asn Thr  His Gly His Val Ser  Asp Ala Ser Ile Ser  Leu Gly Glu 
    1160                 1165                 1170             


Ser Val  Ser Asp Met Ala Pro  Ala Arg Pro Arg Trp  Asn Thr His 
    1175                 1180                 1185             


Gly His  Val Ser Asp Ala Ser  Ile Ser Leu Gly Glu  Ser Val Ser 
    1190                 1195                 1200             


Asp Met  Ala Pro Thr Arg Pro  Arg Trp Asn Thr His  Gly His Val 
    1205                 1210                 1215             


Ser Asp  Thr Ser Ile Arg Val  Gly Glu Asn Val Ser  Asp Val Ala 
    1220                 1225                 1230             


Pro Ile  Arg Ser Arg Cys Asn  Thr His Gly His Val  Ser Asp Ala 
    1235                 1240                 1245             


Ser Ile  Ser Leu Gly Glu Pro  Val Ser Asp Val Val  Ser Thr Arg 
    1250                 1255                 1260             


Pro Arg  Trp Asn Thr His Val  Pro Ile Pro Pro Pro  His Met Val 
    1265                 1270                 1275             


Leu Gly  Ala Leu Ser Pro Glu  Ala Glu Pro Asn Thr  Pro Arg Pro 
    1280                 1285                 1290             


Gln Gln  Ser Pro Pro Gly His  Thr Ser Gln Ser Ala  Leu Ser Leu 
    1295                 1300                 1305             


Gly Ala  Gln Ser Thr Val Leu  Asp Cys Gly Pro Arg  Leu Pro Val 
    1310                 1315                 1320             


Glu Val  Gly Pro Ser Leu Ser  Ser Pro Ser Ser Gly  Cys Gly Glu 
    1325                 1330                 1335             


Gly Ser  Ile Ser Val Gly Glu  Asn Val Ser Asp Val  Ala Pro Thr 
    1340                 1345                 1350             


Gln Pro  Trp Trp Pro Asn Thr  Pro Gly Asp Ser Val  Ser Glu Glu 
    1355                 1360                 1365             


Leu Gly  Pro Gly Arg Ser Gly  Asp Thr Glu Asp Leu  Ser Pro Asn 
    1370                 1375                 1380             


Trp Pro  Leu Asn Ser Gln Glu  Asp Thr Ala Ala Gln  Ser Ser Pro 
    1385                 1390                 1395             


Gly Arg  Gly Glu Glu Ala Glu  Ala Ser Ala Ala Glu  Ala Gln Gly 
    1400                 1405                 1410             


Gly Glu  Gln Ala Tyr Leu Ala  Gly Leu Ala Gly Gln  Tyr His Leu 
    1415                 1420                 1425             


Glu Arg  Tyr Pro Asp Ser Tyr  Glu Ser Met Ser Glu  Pro Pro Ile 
    1430                 1435                 1440             


Ala His  Leu Leu Arg Pro Val  Leu Pro Arg Ala Phe  Ala Phe Pro 
    1445                 1450                 1455             


Val Asp  Pro Gln Val Gln Ser  Ala Ala Asp Glu Thr  Ala Val Gln 
    1460                 1465                 1470             


Leu Ser  Glu Leu Leu Thr Leu  Pro Val Leu Met Lys  Arg Ser Ile 
    1475                 1480                 1485             


Thr Ala  Pro Leu Ala Ala His  Ile Ser Leu Val Asn  Lys Ala Ala 
    1490                 1495                 1500             


Val Asp  Tyr Phe Phe Val Glu  Leu His Leu Glu Ala  His Tyr Glu 
    1505                 1510                 1515             


Ala Leu  Arg His Phe Leu Leu  Met Glu Asp Gly Glu  Phe Ala Gln 
    1520                 1525                 1530             


Ser Leu  Ser Asp Leu Leu Phe  Glu Lys Leu Gly Ala  Gly Gln Thr 
    1535                 1540                 1545             


Pro Gly  Glu Leu Leu Asn Pro  Leu Val Leu Asn Ser  Val Leu Ser 
    1550                 1555                 1560             


Lys Ala  Leu Gln Cys Ser Leu  His Gly Asp Thr Pro  His Ala Ser 
    1565                 1570                 1575             


Asn Leu  Ser Leu Ala Leu Lys  Tyr Leu Pro Glu Val  Phe Ala Pro 
    1580                 1585                 1590             


Asn Ala  Pro Asp Val Leu Ser  Cys Leu Glu Leu Arg  Tyr Lys Val 
    1595                 1600                 1605             


Asp Trp  Pro Leu Asn Ile Val  Ile Thr Glu Gly Cys  Val Ser Lys 
    1610                 1615                 1620             


Tyr Ser  Gly Val Phe Ser Phe  Leu Leu Gln Leu Lys  Leu Met Met 
    1625                 1630                 1635             


Trp Ala  Leu Lys Asp Val Cys  Phe His Leu Lys Arg  Thr Ala Leu 
    1640                 1645                 1650             


Leu Ser  His Met Ala Gly Ser  Val Gln Phe Arg Gln  Leu Gln Leu 
    1655                 1660                 1665             


Phe Lys  His Glu Met Gln His  Phe Val Lys Val Ile  Gln Gly Tyr 
    1670                 1675                 1680             


Ile Ala  Asn Gln Ile Leu His  Val Thr Trp Cys Glu  Phe Arg Ala 
    1685                 1690                 1695             


Arg Leu  Ala Thr Val Gly Asp  Leu Glu Glu Ile Gln  Arg Ala His 
    1700                 1705                 1710             


Ala Glu  Tyr Leu His Lys Ala  Val Phe Arg Gly Leu  Leu Thr Glu 
    1715                 1720                 1725             


Lys Ala  Ala Pro Val Met Asn  Val Ile His Ser Ile  Phe Ser Leu 
    1730                 1735                 1740             


Val Leu  Lys Phe Arg Ser Gln  Leu Ile Ser Gln Ala  Trp Gly Pro 
    1745                 1750                 1755             


Pro Gly  Gly Pro Arg Gly Ala  Glu His Pro Asn Phe  Ala Leu Met 
    1760                 1765                 1770             


Gln Gln  Ser Tyr Asn Thr Phe  Lys Tyr Tyr Ser His  Phe Leu Phe 
    1775                 1780                 1785             


Lys Val  Val Thr Lys Leu Val  Asn Arg Gly Tyr Gln  Pro His Leu 
    1790                 1795                 1800             


Glu Asp  Phe Leu Leu Arg Ile  Asn Phe Asn Asn Tyr  Tyr Gln Asp 
    1805                 1810                 1815             


Ala 
    


<210> 4811
<211> 749
<212> PRT
<213> Homo sapiens

<400> 4811
Met Ser Gly Ser His Thr Pro Ala Cys Gly Pro Phe Ser Ala Leu Thr 
1               5                   10                  15      


Pro Ser Ile Trp Pro Gln Glu Ile Leu Ala Lys Tyr Thr Gln Lys Glu 
            20                  25                  30          


Glu Ser Ala Glu Gln Pro Glu Phe Tyr Tyr Asp Glu Phe Gly Phe Arg 
        35                  40                  45              


Val Tyr Lys Glu Glu Gly Asp Glu Pro Gly Ser Ser Leu Leu Ala Asn 
    50                  55                  60                  


Ser Pro Leu Met Glu Asp Ala Pro Gln Arg Leu Arg Trp Gln Ala His 
65                  70                  75                  80  


Leu Glu Phe Thr His Asn His Asp Val Gly Asp Leu Thr Trp Asp Lys 
                85                  90                  95      


Ile Ala Val Ser Leu Pro Arg Ser Glu Lys Leu Arg Ser Leu Val Leu 
            100                 105                 110         


Ala Gly Ile Pro His Gly Met Arg Pro Gln Leu Trp Met Arg Leu Ser 
        115                 120                 125             


Gly Ala Leu Gln Lys Lys Arg Asn Ser Glu Leu Ser Tyr Arg Glu Ile 
    130                 135                 140                 


Val Lys Asn Ser Ser Asn Asp Glu Thr Ile Ala Ala Lys Gln Ile Glu 
145                 150                 155                 160 


Lys Asp Leu Leu Arg Thr Met Pro Ser Asn Ala Cys Phe Ala Ser Met 
                165                 170                 175     


Gly Ser Ile Gly Val Pro Arg Leu Arg Arg Val Leu Arg Ala Leu Ala 
            180                 185                 190         


Trp Leu Tyr Pro Glu Ile Gly Tyr Cys Gln Gly Thr Gly Met Val Ala 
        195                 200                 205             


Ala Cys Leu Leu Leu Phe Leu Glu Glu Glu Asp Ala Phe Trp Met Met 
    210                 215                 220                 


Ser Ala Ile Ile Glu Asp Leu Leu Pro Ala Ser Tyr Phe Ser Thr Thr 
225                 230                 235                 240 


Leu Leu Gly Val Gln Thr Asp Gln Arg Val Leu Arg His Leu Ile Val 
                245                 250                 255     


Gln Tyr Leu Pro Arg Leu Asp Lys Leu Leu Gln Glu His Asp Ile Glu 
            260                 265                 270         


Leu Ser Leu Ile Thr Leu His Trp Phe Leu Thr Ala Phe Ala Ser Val 
        275                 280                 285             


Val Asp Ile Lys Leu Leu Leu Arg Ile Trp Asp Leu Phe Phe Tyr Glu 
    290                 295                 300                 


Gly Ser Arg Val Leu Phe Gln Leu Thr Leu Gly Met Leu His Leu Lys 
305                 310                 315                 320 


Glu Glu Glu Leu Ile Gln Ser Glu Asn Ser Ala Ser Ile Phe Asn Thr 
                325                 330                 335     


Leu Ser Asp Ile Pro Ser Gln Met Glu Asp Ala Glu Leu Leu Leu Gly 
            340                 345                 350         


Val Ala Met Arg Leu Ala Gly Ser Leu Thr Asp Val Ala Val Glu Thr 
        355                 360                 365             


Gln Arg Arg Lys His Leu Ala Tyr Leu Ile Ala Asp Gln Gly Gln Leu 
    370                 375                 380                 


Leu Gly Ala Gly Thr Leu Thr Asn Leu Ser Gln Val Val Arg Arg Arg 
385                 390                 395                 400 


Thr Gln Arg Arg Lys Ser Thr Ile Thr Ala Leu Leu Phe Gly Glu Asp 
                405                 410                 415     


Asp Leu Glu Ala Leu Lys Ala Lys Asn Ile Lys Gln Thr Glu Leu Val 
            420                 425                 430         


Ala Asp Leu Arg Glu Ala Ile Leu Arg Val Ala Arg His Phe Gln Cys 
        435                 440                 445             


Thr Asp Pro Lys Asn Cys Ser Val Glu Leu Thr Pro Asp Tyr Ser Met 
    450                 455                 460                 


Glu Ser His Gln Arg Asp His Glu Asn Tyr Val Ala Cys Ser Arg Ser 
465                 470                 475                 480 


His Arg Arg Arg Ala Lys Ala Leu Leu Asp Phe Glu Arg His Asp Asp 
                485                 490                 495     


Asp Glu Leu Gly Phe Arg Lys Asn Asp Ile Ile Thr Ile Val Ser Gln 
            500                 505                 510         


Lys Asp Glu His Cys Trp Val Gly Glu Leu Asn Gly Leu Arg Gly Trp 
        515                 520                 525             


Phe Pro Ala Lys Phe Val Glu Val Leu Asp Glu Arg Ser Lys Glu Tyr 
    530                 535                 540                 


Ser Ile Ala Gly Asp Asp Ser Val Thr Glu Gly Val Thr Asp Leu Val 
545                 550                 555                 560 


Arg Gly Thr Leu Cys Pro Ala Leu Lys Ala Leu Phe Glu His Gly Leu 
                565                 570                 575     


Lys Lys Pro Ser Leu Leu Gly Gly Ala Cys His Pro Trp Leu Phe Ile 
            580                 585                 590         


Glu Glu Ala Ala Gly Arg Glu Val Glu Arg Asp Phe Ala Ser Val Tyr 
        595                 600                 605             


Ser Arg Leu Val Leu Cys Lys Thr Phe Arg Leu Asp Glu Asp Gly Lys 
    610                 615                 620                 


Val Leu Thr Pro Glu Glu Leu Leu Tyr Arg Ala Val Gln Ser Val Asn 
625                 630                 635                 640 


Val Thr His Asp Ala Val His Ala Gln Met Asp Val Lys Leu Arg Ser 
                645                 650                 655     


Leu Ile Cys Val Gly Leu Asn Glu Gln Val Leu His Leu Trp Leu Glu 
            660                 665                 670         


Val Leu Cys Ser Ser Leu Pro Thr Val Glu Lys Trp Tyr Gln Pro Trp 
        675                 680                 685             


Ser Phe Leu Arg Ser Pro Gly Trp Val Gln Ile Lys Cys Glu Leu Arg 
    690                 695                 700                 


Val Leu Cys Cys Phe Ala Phe Ser Leu Ser Gln Asp Trp Glu Leu Pro 
705                 710                 715                 720 


Ala Lys Arg Glu Ala Gln Gln Pro Leu Lys Glu Gly Val Arg Asp Met 
                725                 730                 735     


Leu Val Lys His His Leu Phe Ser Trp Asp Val Asp Gly 
            740                 745                 


<210> 4812
<211> 698
<212> PRT
<213> Homo sapiens

<400> 4812
Met Leu Ser Pro Lys Ile Arg Gln Ala Arg Arg Ala Arg Ser Lys Ser 
1               5                   10                  15      


Leu Val Met Gly Glu Gln Ser Arg Ser Pro Gly Arg Met Pro Cys Pro 
            20                  25                  30          


His Arg Leu Gly Pro Val Leu Lys Ala Gly Trp Leu Lys Lys Gln Arg 
        35                  40                  45              


Ser Ile Met Lys Asn Trp Gln Gln Arg Trp Phe Val Leu Arg Gly Asp 
    50                  55                  60                  


Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu Ile Lys Pro Gln Gly Phe 
65                  70                  75                  80  


Ile Ser Leu Gln Gly Thr Gln Val Thr Glu Leu Pro Pro Gly Pro Glu 
                85                  90                  95      


Asp Pro Gly Lys His Leu Phe Glu Ile Ser Pro Gly Gly Ala Gly Glu 
            100                 105                 110         


Arg Glu Lys Val Pro Ala Asn Pro Glu Ala Leu Leu Leu Met Ala Ser 
        115                 120                 125             


Ser Gln Arg Asp Met Glu Asp Trp Val Gln Ala Ile Arg Arg Val Ile 
    130                 135                 140                 


Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly Gln Arg Leu Glu Glu Thr 
145                 150                 155                 160 


Val His His Glu Arg Lys Tyr Gly Pro Arg Leu Ala Pro Leu Leu Val 
                165                 170                 175     


Glu Gln Cys Val Asp Phe Ile Arg Glu Arg Gly Leu Thr Glu Glu Gly 
            180                 185                 190         


Leu Phe Arg Met Pro Gly Gln Ala Asn Leu Val Arg Asp Leu Gln Asp 
        195                 200                 205             


Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe Asp Ser Thr Thr Asp Val 
    210                 215                 220                 


His Thr Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu 
225                 230                 235                 240 


Pro Val Val Pro Phe Ala Arg Tyr Glu Asp Phe Leu Ser Cys Ala Gln 
                245                 250                 255     


Leu Leu Thr Lys Asp Glu Gly Glu Gly Thr Leu Glu Leu Ala Lys Gln 
            260                 265                 270         


Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn Leu Leu Arg Tyr Ile Cys 
        275                 280                 285             


Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn Lys Met Ser 
    290                 295                 300                 


Val Gln Asn Leu Ala Thr Val Phe Gly Pro Asn Ile Leu Arg Pro Gln 
305                 310                 315                 320 


Val Glu Asp Pro Val Thr Ile Met Glu Gly Thr Ser Leu Val Gln His 
                325                 330                 335     


Leu Met Thr Val Leu Ile Arg Lys His Ser Gln Leu Phe Thr Ala Pro 
            340                 345                 350         


Val Pro Glu Gly Pro Thr Ser Pro Arg Gly Gly Leu Gln Cys Ala Val 
        355                 360                 365             


Gly Trp Gly Ser Glu Glu Val Thr Arg Asp Ser Gln Gly Glu Pro Gly 
    370                 375                 380                 


Gly Pro Gly Leu Pro Ala His Arg Thr Ser Ser Leu Asp Gly Ala Ala 
385                 390                 395                 400 


Val Ala Val Leu Ser Arg Thr Ala Pro Thr Gly Pro Gly Ser Arg Cys 
                405                 410                 415     


Ser Pro Gly Lys Lys Val Gln Thr Leu Pro Ser Trp Lys Ser Ser Phe 
            420                 425                 430         


Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly Gly Ser Ser 
        435                 440                 445             


Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu Met Asn Gly 
    450                 455                 460                 


Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly Asp Arg Leu 
465                 470                 475                 480 


Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Thr Tyr Asp Asn Val Pro 
                485                 490                 495     


Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser Met Ala Trp 
            500                 505                 510         


Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser Leu Ser Ser 
        515                 520                 525             


Cys Thr Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser Ser Leu His 
    530                 535                 540                 


Thr Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser Ser Glu Asp 
545                 550                 555                 560 


Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala Gly Ala Gly 
                565                 570                 575     


Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Thr Arg Glu His 
            580                 585                 590         


Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Thr Glu Leu Arg Ala 
        595                 600                 605             


Glu Leu Cys Arg Gln Arg Thr Glu Tyr Glu Arg Ser Val Lys Arg Ile 
    610                 615                 620                 


Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg Leu Glu Glu 
625                 630                 635                 640 


Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu Ile Lys Leu 
                645                 650                 655     


Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg Asn Gln Leu 
            660                 665                 670         


Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Thr Leu Gly Ser Leu Thr 
        675                 680                 685             


Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
    690                 695             


<210> 4813
<211> 59
<212> PRT
<213> Homo sapiens

<400> 4813
Met Thr Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Gln Ser Asp Ser Val Lys Gly Lys Arg Arg Asp Asp Gly Leu Ser 
            20                  25                  30          


Ala Ala Ala Arg Lys Gln Arg Asp Ser Glu Ile Met Gln Gln Lys Gln 
        35                  40                  45              


Lys Lys Ala Asn Glu Lys Lys Glu Glu Pro Lys 
    50                  55                  


<210> 4814
<211> 123
<212> PRT
<213> Homo sapiens

<400> 4814
Met Ala Arg Tyr Glu Glu Val Ser Val Ser Gly Phe Glu Glu Phe His 
1               5                   10                  15      


Arg Ala Val Glu Gln His Asn Gly Lys Thr Ile Phe Ala Tyr Phe Thr 
            20                  25                  30          


Gly Ser Lys Asp Ala Gly Gly Lys Ser Trp Cys Pro Asp Cys Val Gln 
        35                  40                  45              


Ala Glu Pro Val Val Arg Glu Gly Leu Lys His Ile Ser Glu Gly Cys 
    50                  55                  60                  


Val Phe Ile Tyr Cys Gln Val Gly Glu Lys Pro Tyr Trp Lys Asp Pro 
65                  70                  75                  80  


Asn Asn Asp Phe Arg Lys Asn Leu Lys Val Thr Ala Val Pro Thr Leu 
                85                  90                  95      


Leu Lys Tyr Gly Thr Pro Gln Lys Leu Val Glu Ser Glu Cys Leu Gln 
            100                 105                 110         


Ala Asn Leu Val Glu Met Leu Phe Ser Glu Asp 
        115                 120             


<210> 4815
<211> 466
<212> PRT
<213> Homo sapiens

<400> 4815
Met Gly Trp Ile Thr Glu Asp Leu Ile Arg Arg Asn Ala Glu His Asn 
1               5                   10                  15      


Asp Cys Val Ile Phe Ser Leu Glu Glu Leu Ser Leu His Gln Gln Glu 
            20                  25                  30          


Ile Glu Arg Leu Glu His Ile Asp Lys Trp Cys Arg Asp Leu Lys Ile 
        35                  40                  45              


Leu Tyr Leu Gln Asn Asn Leu Ile Gly Lys Ile Glu Asn Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Leu Glu Tyr Leu Asn Leu Ala Leu Asn Asn Ile Glu Lys 
65                  70                  75                  80  


Ile Glu Asn Leu Glu Gly Cys Glu Glu Leu Ala Lys Leu Asp Leu Thr 
                85                  90                  95      


Val Asn Phe Ile Gly Glu Leu Ser Ser Ile Lys Asn Leu Gln His Asn 
            100                 105                 110         


Ile His Leu Lys Glu Leu Phe Leu Met Gly Asn Pro Cys Ala Ser Phe 
        115                 120                 125             


Asp His Tyr Arg Glu Phe Val Val Ala Thr Leu Pro Gln Leu Lys Trp 
    130                 135                 140                 


Leu Asp Gly Lys Glu Ile Glu Pro Ser Glu Arg Ile Lys Ala Leu Gln 
145                 150                 155                 160 


Asp Tyr Ser Val Ile Glu Pro Gln Ile Arg Glu Gln Glu Lys Asp His 
                165                 170                 175     


Cys Leu Lys Arg Ala Lys Leu Lys Glu Glu Ala Gln Arg Lys His Gln 
            180                 185                 190         


Glu Glu Asp Lys Asn Glu Asp Lys Arg Ser Asn Ala Gly Phe Asp Gly 
        195                 200                 205             


Arg Trp Tyr Thr Asp Ile Asn Ala Thr Leu Ser Ser Leu Glu Ser Lys 
    210                 215                 220                 


Asp His Leu Gln Ala Pro Asp Thr Glu Glu His Asn Thr Lys Lys Leu 
225                 230                 235                 240 


Asp Asn Ser Glu Asp Asp Leu Glu Phe Trp Asn Lys Pro Cys Leu Phe 
                245                 250                 255     


Thr Pro Glu Ser Arg Leu Glu Thr Leu Arg His Met Glu Lys Gln Arg 
            260                 265                 270         


Lys Lys Gln Glu Lys Leu Ser Glu Lys Lys Lys Lys Val Lys Pro Pro 
        275                 280                 285             


Arg Thr Leu Ile Thr Glu Asp Gly Lys Ala Leu Asn Val Asn Glu Pro 
    290                 295                 300                 


Lys Ile Asp Phe Ser Leu Lys Asp Asn Glu Lys Gln Ile Ile Leu Asp 
305                 310                 315                 320 


Leu Ala Val Tyr Arg Tyr Met Asp Thr Ser Leu Ile Asp Val Asp Val 
                325                 330                 335     


Gln Pro Thr Tyr Val Arg Val Met Ile Lys Gly Lys Pro Phe Gln Leu 
            340                 345                 350         


Val Leu Pro Ala Glu Val Lys Pro Asp Ser Ser Ser Ala Lys Arg Ser 
        355                 360                 365             


Gln Thr Thr Gly His Leu Val Ile Cys Met Pro Lys Val Gly Glu Val 
    370                 375                 380                 


Ile Thr Gly Gly Gln Arg Ala Phe Lys Ser Met Lys Thr Thr Ser Asp 
385                 390                 395                 400 


Arg Ser Arg Glu Gln Thr Asn Thr Arg Ser Lys His Met Glu Lys Leu 
                405                 410                 415     


Glu Val Asp Pro Ser Lys His Ser Phe Pro Asp Val Thr Asn Ile Val 
            420                 425                 430         


Gln Glu Lys Lys His Thr Pro Arg Arg Arg Pro Glu Pro Lys Ile Ile 
        435                 440                 445             


Pro Ser Glu Glu Asp Pro Thr Phe Glu Asp Asn Pro Glu Val Pro Pro 
    450                 455                 460                 


Leu Ile 
465     


<210> 4816
<211> 349
<212> PRT
<213> Homo sapiens

<400> 4816
Met Glu Asp Pro Gln Ser Lys Glu Pro Ala Gly Glu Ala Val Ala Leu 
1               5                   10                  15      


Ala Leu Leu Glu Ser Pro Arg Pro Glu Gly Gly Glu Glu Pro Pro Arg 
            20                  25                  30          


Pro Ser Pro Glu Glu Thr Gln Gln Cys Lys Phe Asp Gly Gln Glu Thr 
        35                  40                  45              


Lys Gly Ser Lys Phe Ile Thr Ser Ser Ala Ser Asp Phe Ser Asp Pro 
    50                  55                  60                  


Val Tyr Lys Glu Ile Ala Ile Thr Asn Gly Cys Ile Asn Arg Met Ser 
65                  70                  75                  80  


Lys Glu Glu Leu Arg Ala Lys Leu Ser Glu Phe Lys Leu Glu Thr Arg 
                85                  90                  95      


Gly Val Lys Asp Val Leu Lys Lys Arg Leu Lys Asn Tyr Tyr Lys Lys 
            100                 105                 110         


Gln Lys Leu Met Leu Lys Glu Ser Asn Phe Ala Asp Ser Tyr Tyr Asp 
        115                 120                 125             


Tyr Ile Cys Ile Ile Asp Phe Glu Ala Thr Cys Glu Glu Gly Asn Pro 
    130                 135                 140                 


Pro Glu Phe Val His Glu Ile Ile Glu Phe Pro Val Val Leu Leu Asn 
145                 150                 155                 160 


Thr His Thr Leu Glu Ile Glu Asp Thr Phe Gln Gln Tyr Val Arg Pro 
                165                 170                 175     


Glu Ile Asn Thr Gln Leu Ser Asp Phe Cys Ile Ser Leu Thr Gly Ile 
            180                 185                 190         


Thr Gln Asp Gln Val Asp Arg Ala Asp Thr Phe Pro Gln Val Leu Lys 
        195                 200                 205             


Lys Val Ile Asp Trp Met Lys Leu Lys Glu Leu Gly Thr Lys Tyr Lys 
    210                 215                 220                 


Tyr Ser Leu Leu Thr Asp Gly Ser Trp Asp Met Ser Lys Phe Leu Asn 
225                 230                 235                 240 


Ile Gln Cys Gln Leu Ser Arg Leu Lys Tyr Pro Pro Phe Ala Lys Lys 
                245                 250                 255     


Trp Ile Asn Ile Arg Lys Ser Tyr Gly Asn Phe Tyr Lys Val Pro Arg 
            260                 265                 270         


Ser Gln Thr Lys Leu Thr Ile Met Leu Glu Lys Leu Gly Met Asp Tyr 
        275                 280                 285             


Asp Gly Arg Pro His Cys Gly Leu Asp Asp Ser Lys Asn Ile Ala Arg 
    290                 295                 300                 


Ile Ala Val Arg Met Leu Gln Asp Gly Cys Glu Leu Arg Ile Asn Glu 
305                 310                 315                 320 


Lys Met His Ala Gly Gln Leu Met Ser Val Ser Ser Ser Leu Pro Ile 
                325                 330                 335     


Glu Gly Thr Pro Pro Pro Gln Met Pro His Phe Arg Lys 
            340                 345                 


<210> 4817
<211> 280
<212> PRT
<213> Homo sapiens

<400> 4817
Met Leu Ser Ala Val Ala Arg Gly Tyr Gln Gly Trp Phe His Pro Cys 
1               5                   10                  15      


Ala Arg Leu Ser Val Arg Met Ser Ser Thr Gly Ile Asp Arg Lys Gly 
            20                  25                  30          


Val Leu Ala Asn Arg Val Ala Val Val Thr Gly Ser Thr Ser Gly Ile 
        35                  40                  45              


Gly Phe Ala Ile Ala Arg Arg Leu Ala Arg Asp Gly Ala His Val Val 
    50                  55                  60                  


Ile Ser Ser Arg Lys Gln Gln Asn Val Asp Arg Ala Met Ala Lys Leu 
65                  70                  75                  80  


Gln Gly Glu Gly Leu Ser Val Ala Gly Ile Val Cys His Val Gly Lys 
                85                  90                  95      


Ala Glu Asp Arg Glu Gln Leu Val Ala Lys Ala Leu Glu His Cys Gly 
            100                 105                 110         


Gly Val Asp Phe Leu Val Cys Ser Ala Gly Val Asn Pro Leu Val Gly 
        115                 120                 125             


Ser Thr Leu Gly Thr Ser Glu Gln Ile Trp Asp Lys Ile Leu Ser Val 
    130                 135                 140                 


Asn Val Lys Ser Pro Ala Leu Leu Leu Ser Gln Leu Leu Pro Tyr Met 
145                 150                 155                 160 


Glu Asn Arg Arg Gly Ala Val Ile Leu Val Ser Ser Ile Ala Ala Tyr 
                165                 170                 175     


Asn Pro Val Val Ala Leu Gly Val Tyr Asn Val Ser Lys Thr Ala Leu 
            180                 185                 190         


Leu Gly Leu Thr Arg Thr Leu Ala Leu Glu Leu Ala Pro Lys Asp Ile 
        195                 200                 205             


Arg Val Asn Cys Val Val Pro Gly Ile Ile Lys Thr Asp Phe Ser Lys 
    210                 215                 220                 


Val Phe His Gly Asn Glu Ser Leu Trp Lys Asn Phe Lys Glu His His 
225                 230                 235                 240 


Gln Leu Gln Arg Ile Gly Glu Ser Glu Asp Cys Ala Gly Ile Val Ser 
                245                 250                 255     


Phe Leu Cys Ser Pro Asp Ala Ser Tyr Val Asn Gly Glu Asn Ile Ala 
            260                 265                 270         


Val Ala Gly Tyr Ser Thr Arg Leu 
        275                 280 


<210> 4818
<211> 302
<212> PRT
<213> Homo sapiens

<400> 4818
Met Val Thr Glu Gln Glu Val Asp Ala Ile Gly Gln Thr Leu Val Asp 
1               5                   10                  15      


Pro Lys Gln Pro Leu Gln Ala Arg Phe Arg Ala Leu Phe Thr Leu Arg 
            20                  25                  30          


Gly Leu Gly Gly Pro Gly Ala Ile Ala Trp Ile Ser Gln Ala Phe Asp 
        35                  40                  45              


Asp Asp Ser Ala Leu Leu Lys His Glu Leu Ala Tyr Cys Leu Gly Gln 
    50                  55                  60                  


Met Gln Asp Ala Arg Ala Ile Pro Met Leu Val Asp Val Leu Gln Asp 
65                  70                  75                  80  


Thr Arg Gln Glu Pro Met Val Arg His Glu Ala Gly Glu Ala Leu Gly 
                85                  90                  95      


Ala Ile Gly Asp Pro Glu Val Leu Glu Ile Leu Lys Gln Tyr Ser Ser 
            100                 105                 110         


Asp Pro Val Ile Glu Val Ala Glu Thr Cys Gln Leu Ala Val Arg Arg 
        115                 120                 125             


Leu Glu Trp Leu Gln Gln His Gly Gly Glu Pro Ala Ala Gly Pro Tyr 
    130                 135                 140                 


Leu Ser Val Asp Pro Ala Pro Pro Ala Glu Glu Arg Asp Val Gly Arg 
145                 150                 155                 160 


Leu Arg Glu Ala Leu Leu Asp Glu Ser Arg Pro Leu Phe Glu Arg Tyr 
                165                 170                 175     


Arg Ala Met Phe Ala Leu Arg Asn Ala Gly Gly Glu Glu Ala Ala Leu 
            180                 185                 190         


Ala Leu Ala Glu Gly Leu His Cys Gly Ser Ala Leu Phe Arg His Glu 
        195                 200                 205             


Val Gly Tyr Val Leu Gly Gln Leu Gln His Glu Ala Ala Val Pro Gln 
    210                 215                 220                 


Leu Ala Ala Ala Leu Ala Arg Cys Thr Glu Asn Pro Met Val Arg His 
225                 230                 235                 240 


Glu Cys Ala Glu Ala Leu Gly Ala Ile Ala Arg Pro Ala Cys Leu Ala 
                245                 250                 255     


Ala Leu Gln Ala His Ala Asp Asp Pro Glu Arg Val Val Arg Glu Ser 
            260                 265                 270         


Cys Glu Val Ala Leu Asp Met Tyr Glu His Glu Thr Gly Arg Ala Phe 
        275                 280                 285             


Gln Tyr Ala Asp Gly Leu Glu Gln Leu Arg Gly Ala Pro Ser 
    290                 295                 300         


<210> 4819
<211> 1127
<212> PRT
<213> Homo sapiens

<400> 4819
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Thr Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Thr Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Thr Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Thr Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Thr Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Thr Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Thr Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Thr Thr Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys 
        435                 440                 445             


Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro 
            500                 505                 510         


Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser 
        515                 520                 525             


Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Thr 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Thr Ser Ser Pro Val Thr 
        675                 680                 685             


Cys Ser Ser Asn Ala Cys Leu Val Thr Thr Asp Gln Ala Ser Ser Gly 
    690                 695                 700                 


Ser Glu Thr Glu Phe Met Thr Ser Glu Thr Pro Glu Ala Ala Ile Pro 
705                 710                 715                 720 


Pro Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala 
                725                 730                 735     


Lys Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser 
            740                 745                 750         


Val Thr Ile Asn Thr Ala Pro Phe Gln Ala Met Gln Thr Val Phe Asn 
        755                 760                 765             


Val Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser 
    770                 775                 780                 


Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln 
785                 790                 795                 800 


Thr Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Thr Val 
                805                 810                 815     


His Ser Gln Glu Thr Ala Ala Asn Tyr His Pro Asp Gly Thr Ile Gln 
            820                 825                 830         


Val Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Thr Asn Val Phe 
        835                 840                 845             


Pro Arg Pro Thr Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg Gly 
    850                 855                 860                 


Cys Thr Arg Gly Gly Arg Leu Ile Thr Asn Ser Tyr Arg Ser Pro Gly 
865                 870                 875                 880 


Gly Tyr Lys Gly Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile Ser Asn 
                885                 890                 895     


Gly Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala 
            900                 905                 910         


Pro Tyr Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg Gly Gly 
        915                 920                 925             


Thr Ser Gly Gly Pro Arg Ala Asn Ser Arg Ala Gly Trp Ser Asp Ser 
    930                 935                 940                 


Ser Gln Val Ser Ser Pro Glu Arg Asp Asn Glu Thr Phe Asn Ser Gly 
945                 950                 955                 960 


Asp Ser Gly Gln Gly Asp Ser Arg Ser Met Thr Pro Val Asp Val Pro 
                965                 970                 975     


Val Thr Asn Pro Ala Ala Thr Ile Leu Pro Val His Val Tyr Pro Leu 
            980                 985                 990         


Pro Gln Gln Met Arg Val Ala Phe  Ser Ala Ala Arg Thr  Ser Asn Leu 
        995                 1000                 1005             


Ala Pro  Gly Thr Leu Asp Gln  Pro Ile Val Phe Asp  Leu Leu Leu 
    1010                 1015                 1020             


Asn Asn  Leu Gly Glu Thr Phe  Asp Leu Gln Leu Gly  Arg Phe Asn 
    1025                 1030                 1035             


Cys Pro  Val Asn Gly Thr Tyr  Val Phe Ile Phe His  Met Leu Lys 
    1040                 1045                 1050             


Leu Ala  Val Asn Val Pro Leu  Tyr Val Asn Leu Met  Lys Asn Glu 
    1055                 1060                 1065             


Glu Val  Leu Val Ser Ala Tyr  Ala Asn Asp Gly Ala  Pro Asp His 
    1070                 1075                 1080             


Glu Thr  Ala Ser Asn His Ala  Ile Leu Gln Leu Phe  Gln Gly Asp 
    1085                 1090                 1095             


Gln Ile  Trp Leu Arg Leu His  Arg Gly Ala Ile Tyr  Gly Ser Ser 
    1100                 1105                 1110             


Trp Lys  Tyr Ser Thr Phe Ser  Gly Tyr Leu Leu Tyr  Gln Asp 
    1115                 1120                 1125         


<210> 4820
<211> 815
<212> PRT
<213> Homo sapiens

<400> 4820
Met Glu Val Arg Ala Ser Leu Gln Lys Val Ser Gly Ser Ser Asp Ser 
1               5                   10                  15      


Val Ala Thr Met Asn Ser Glu Glu Phe Val Leu Val Pro Gln Tyr Ala 
            20                  25                  30          


Asp Asp Asn Ser Thr Lys His Glu Glu Lys Pro Gln Leu Lys Ile Val 
        35                  40                  45              


Ser Asn Gly Asp Glu Gln Leu Glu Lys Ala Met Glu Glu Ile Leu Arg 
    50                  55                  60                  


Asp Ser Glu Lys Arg Pro Ser Ser Leu Leu Val Asp Cys Gln Ser Ser 
65                  70                  75                  80  


Ser Glu Ile Ser Asp His Ser Phe Gly Asp Ile Pro Ala Ser Gln Thr 
                85                  90                  95      


Asn Lys Pro Ser Leu Gln Leu Ile Leu Asp Pro Ser Asn Thr Glu Ile 
            100                 105                 110         


Ser Thr Pro Arg Pro Ser Ser Pro Gly Gly Leu Pro Glu Glu Asp Ser 
        115                 120                 125             


Val Leu Phe Asn Lys Leu Thr Tyr Leu Gly Cys Met Lys Val Ser Ser 
    130                 135                 140                 


Pro Arg Asn Glu Val Glu Ala Leu Arg Ala Met Ala Thr Met Lys Ser 
145                 150                 155                 160 


Ser Ser Gln Tyr Pro Phe Pro Val Thr Leu Tyr Val Pro Asn Val Pro 
                165                 170                 175     


Glu Gly Ser Val Arg Ile Ile Asp Gln Ser Ser Asn Val Glu Ile Ala 
            180                 185                 190         


Ser Phe Pro Ile Tyr Lys Val Leu Phe Cys Ala Arg Gly His Asp Gly 
        195                 200                 205             


Thr Thr Glu Ser Asn Cys Phe Ala Phe Thr Glu Ser Ser His Gly Ser 
    210                 215                 220                 


Glu Glu Phe Gln Ile His Val Phe Ser Cys Glu Ile Lys Glu Ala Val 
225                 230                 235                 240 


Ser Arg Ile Leu Tyr Ser Phe Cys Thr Ala Phe Lys Arg Ser Ser Arg 
                245                 250                 255     


Gln Val Ser Asp Val Lys Asp Ser Val Ile Pro Thr Pro Asp Ser Asp 
            260                 265                 270         


Val Phe Thr Phe Ser Val Ser Leu Glu Val Lys Glu Asp Asp Gly Lys 
        275                 280                 285             


Gly Asn Phe Ser Pro Val Pro Lys Asp Arg Asp Lys Phe Tyr Phe Lys 
    290                 295                 300                 


Leu Lys Gln Gly Ile Glu Lys Lys Val Val Ile Thr Val Gln Gln Leu 
305                 310                 315                 320 


Ser Asn Lys Glu Leu Ala Ile Glu Arg Cys Phe Gly Met Leu Leu Ser 
                325                 330                 335     


Pro Gly Arg Asn Val Lys Asn Ser Asp Met His Leu Leu Asp Met Glu 
            340                 345                 350         


Ser Met Gly Lys Ser Tyr Asp Gly Arg Ala Tyr Val Ile Thr Gly Met 
        355                 360                 365             


Trp Asn Pro Asn Ala Pro Val Phe Leu Ala Leu Asn Glu Glu Thr Pro 
    370                 375                 380                 


Lys Asp Lys Gln Val Tyr Met Thr Val Ala Val Asp Met Val Val Thr 
385                 390                 395                 400 


Glu Val Val Glu Pro Val Arg Phe Leu Leu Glu Thr Val Val Arg Val 
                405                 410                 415     


Tyr Pro Ala Asn Glu Arg Phe Trp Tyr Phe Ser Arg Lys Thr Phe Thr 
            420                 425                 430         


Glu Thr Phe Phe Met Arg Leu Lys Gln Ser Glu Gly Lys Gly His Thr 
        435                 440                 445             


Asn Ala Gly Asp Ala Ile Tyr Glu Val Val Ser Leu Gln Arg Glu Ser 
    450                 455                 460                 


Asp Lys Glu Glu Pro Val Thr Pro Thr Ser Gly Gly Gly Pro Met Ser 
465                 470                 475                 480 


Pro Gln Asp Asp Glu Ala Glu Glu Glu Ser Asp Asn Glu Leu Ser Ser 
                485                 490                 495     


Gly Thr Gly Asp Val Ser Lys Asp Cys Pro Glu Lys Ile Leu Tyr Ser 
            500                 505                 510         


Trp Gly Glu Leu Leu Gly Lys Trp His Ser Asn Leu Gly Ala Arg Pro 
        515                 520                 525             


Lys Gly Leu Ser Thr Leu Val Lys Ser Gly Val Pro Glu Ala Leu Arg 
    530                 535                 540                 


Ala Glu Val Trp Gln Leu Leu Ala Gly Cys His Asp Asn Gln Ala Met 
545                 550                 555                 560 


Leu Asp Arg Tyr Arg Ile Leu Ile Thr Lys Asp Ser Ala Gln Glu Ser 
                565                 570                 575     


Val Ile Thr Arg Asp Ile His Arg Thr Phe Pro Ala His Asp Tyr Phe 
            580                 585                 590         


Lys Asp Thr Gly Gly Asp Gly Gln Glu Ser Leu Tyr Lys Ile Cys Lys 
        595                 600                 605             


Ala Tyr Ser Val Tyr Asp Glu Asp Ile Gly Tyr Cys Gln Gly Gln Ser 
    610                 615                 620                 


Phe Leu Ala Ala Val Leu Leu Leu His Met Pro Glu Glu Gln Ala Phe 
625                 630                 635                 640 


Cys Val Leu Val Lys Ile Met Tyr Asp Tyr Gly Leu Arg Asp Leu Tyr 
                645                 650                 655     


Arg Asn Asn Phe Glu Asp Leu His Cys Lys Phe Tyr Gln Leu Glu Arg 
            660                 665                 670         


Leu Met Gln Glu Gln Leu Pro Asp Leu His Ser His Phe Ser Asp Leu 
        675                 680                 685             


Asn Leu Glu Ala His Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe 
    690                 695                 700                 


Thr Ala Lys Phe Pro Leu Cys Met Val Phe His Ile Ile Asp Leu Leu 
705                 710                 715                 720 


Leu Cys Glu Gly Leu Asn Ile Ile Phe His Val Ala Leu Ala Leu Leu 
                725                 730                 735     


Lys Thr Ser Lys Glu Asp Leu Leu Gln Ala Asp Phe Glu Gly Ala Leu 
            740                 745                 750         


Lys Phe Phe Arg Val Gln Leu Pro Lys Arg Tyr Arg Ala Glu Glu Asn 
        755                 760                 765             


Ala Arg Arg Leu Met Glu Gln Ala Cys Asn Ile Lys Val Pro Thr Lys 
    770                 775                 780                 


Lys Leu Lys Lys Tyr Glu Lys Glu Tyr Gln Thr Met Arg Glu Ser Gln 
785                 790                 795                 800 


Leu Gln Gln Glu Asp Pro Met Asp Arg Tyr Lys Phe Val Tyr Leu 
                805                 810                 815 


<210> 4821
<211> 212
<212> PRT
<213> Homo sapiens

<400> 4821
Met Ala Gln Thr Asp Lys Pro Thr Cys Ile Pro Pro Glu Leu Pro Lys 
1               5                   10                  15      


Met Leu Lys Glu Phe Ala Lys Ala Ala Ile Arg Ala Gln Pro Gln Asp 
            20                  25                  30          


Leu Ile Gln Trp Gly Ala Asp Tyr Phe Glu Ala Leu Ser Arg Gly Glu 
        35                  40                  45              


Thr Pro Pro Val Arg Glu Arg Ser Glu Arg Val Ala Leu Cys Asn Trp 
    50                  55                  60                  


Ala Glu Leu Thr Pro Glu Leu Leu Lys Ile Leu His Ser Gln Val Ala 
65                  70                  75                  80  


Gly Arg Leu Ile Ile Arg Ala Glu Glu Leu Ala Gln Met Trp Lys Val 
                85                  90                  95      


Val Asn Leu Pro Thr Asp Leu Phe Asn Ser Val Met Asn Val Gly Arg 
            100                 105                 110         


Phe Thr Glu Glu Ile Glu Trp Leu Lys Phe Leu Ala Leu Ala Cys Ser 
        115                 120                 125             


Ala Leu Gly Val Thr Ile Thr Lys Thr Leu Lys Ile Val Cys Glu Val 
    130                 135                 140                 


Leu Ser Cys Asp His Asn Gly Gly Leu Pro Arg Ile Pro Phe Ser Thr 
145                 150                 155                 160 


Phe Gln Phe Leu Tyr Thr Tyr Ile Ala Glu Val Asp Gly Glu Ile Cys 
                165                 170                 175     


Ala Ser His Val Ser Arg Met Leu Asn Tyr Ile Glu Gln Glu Val Ile 
            180                 185                 190         


Gly Pro Asp Gly Leu Ile Thr Val Asn Asp Phe Thr Gln Asn Pro Arg 
        195                 200                 205             


Val Trp Leu Glu 
    210         


<210> 4822
<211> 645
<212> PRT
<213> Homo sapiens

<400> 4822
Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr Asp Gln Asp Leu Leu 
1               5                   10                  15      


Leu Met Gln Glu Gly Met Pro Met Arg Lys Val Arg Ser Lys Ser Trp 
            20                  25                  30          


Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp Gly Met Thr Val Trp 
        35                  40                  45              


His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro Ser Phe Ser Ile Ser 
    50                  55                  60                  


Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser Glu Leu Leu Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe Thr Ile Val Phe His 
                85                  90                  95      


Gly Arg Arg Ser Asn Leu Asp Leu Met Ala Asn Ser Val Glu Glu Ala 
            100                 105                 110         


Gln Ile Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser 
        115                 120                 125             


Met Asp His Gln Glu Arg Leu Asp Gln Trp Leu Ser Asp Trp Phe Gln 
    130                 135                 140                 


Arg Gly Asp Lys Asn Gln Asp Gly Lys Met Ser Phe Gln Glu Val Gln 
145                 150                 155                 160 


Arg Leu Leu His Leu Met Asn Val Glu Met Asp Gln Glu Tyr Ala Phe 
                165                 170                 175     


Ser Leu Phe Gln Ala Ala Asp Thr Ser Gln Ser Gly Thr Leu Glu Gly 
            180                 185                 190         


Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Ala Glu Val 
        195                 200                 205             


Gln Glu Leu Phe Glu Ser Phe Ser Ala Asp Gly Gln Lys Leu Thr Leu 
    210                 215                 220                 


Leu Glu Phe Leu Asp Phe Leu Gln Glu Glu Gln Lys Glu Arg Asp Cys 
225                 230                 235                 240 


Thr Ser Glu Leu Ala Leu Glu Leu Ile Asp Arg Tyr Glu Pro Ser Asp 
                245                 250                 255     


Ser Gly Lys Leu Arg His Val Leu Ser Met Asp Gly Phe Leu Ser Tyr 
            260                 265                 270         


Leu Cys Ser Lys Asp Gly Asp Ile Phe Asn Pro Ala Cys Leu Pro Ile 
        275                 280                 285             


Tyr Gln Asp Met Thr Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser 
    290                 295                 300                 


His Asn Thr Tyr Leu Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val 
305                 310                 315                 320 


Glu Gly Tyr Ile Arg Ala Leu Lys Arg Gly Cys Arg Cys Val Glu Val 
                325                 330                 335     


Asp Val Trp Asp Gly Pro Ser Gly Glu Pro Val Val Tyr His Gly His 
            340                 345                 350         


Thr Leu Thr Ser Arg Ile Leu Phe Lys Asp Val Val Ala Thr Val Ala 
        355                 360                 365             


Gln Tyr Ala Phe Gln Thr Ser Asp Tyr Pro Val Ile Leu Ser Leu Glu 
    370                 375                 380                 


Thr His Cys Ser Trp Glu Gln Gln Gln Thr Met Ala Arg His Leu Thr 
385                 390                 395                 400 


Glu Ile Leu Gly Glu Gln Leu Leu Ser Thr Thr Leu Asp Gly Val Leu 
                405                 410                 415     


Pro Thr Gln Leu Pro Ser Pro Glu Glu Leu Arg Arg Lys Ile Leu Val 
            420                 425                 430         


Lys Gly Lys Lys Leu Thr Leu Glu Glu Asp Leu Glu Tyr Glu Glu Glu 
        435                 440                 445             


Glu Ala Glu Pro Glu Leu Glu Glu Ser Glu Leu Ala Leu Glu Ser Gln 
    450                 455                 460                 


Phe Glu Thr Glu Pro Glu Pro Gln Glu Gln Asn Leu Gln Asn Lys Asp 
465                 470                 475                 480 


Lys Lys Lys Lys Ser Lys Pro Ile Leu Cys Pro Ala Leu Ser Ser Leu 
                485                 490                 495     


Val Ile Tyr Leu Lys Ser Val Ser Phe Arg Ser Phe Thr His Ser Lys 
            500                 505                 510         


Glu His Tyr His Phe Tyr Glu Ile Ser Ser Phe Ser Glu Thr Lys Ala 
        515                 520                 525             


Lys Arg Leu Ile Lys Glu Ala Gly Asn Glu Phe Val Gln His Asn Thr 
    530                 535                 540                 


Trp Gln Leu Ser Arg Val Tyr Pro Ser Gly Leu Arg Thr Asp Ser Ser 
545                 550                 555                 560 


Asn Tyr Asn Pro Gln Glu Leu Trp Asn Ala Gly Cys Gln Met Val Ala 
                565                 570                 575     


Met Asn Met Gln Thr Ala Gly Leu Glu Met Asp Ile Cys Asp Gly His 
            580                 585                 590         


Phe Arg Gln Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro Asp Phe Leu 
        595                 600                 605             


Arg Asp Ile Gln Ser Ser Phe His Pro Glu Lys Pro Ile Ser Pro Phe 
    610                 615                 620                 


Lys Ala Gln Thr Leu Ser Ile Pro Tyr Arg His Leu Gln Leu Ile Phe 
625                 630                 635                 640 


Pro Ile Asn Ser Val 
                645 


<210> 4823
<211> 2517
<212> PRT
<213> Homo sapiens

<400> 4823
Met Val Gly Glu Arg His Ala Gly Asp Leu Met Val Pro Leu Gly Pro 
1               5                   10                  15      


Arg Leu Gln Ala Tyr Pro Glu Glu Leu Ile Arg Gln Arg Pro Gly His 
            20                  25                  30          


Asp Gly His Pro Glu Tyr Leu Ile Arg Trp Ser Val Leu Lys Cys Gly 
        35                  40                  45              


Glu Val Gly Lys Val Gly Val Glu Glu Gly Lys Ala Glu His Ile Leu 
    50                  55                  60                  


Met Trp Leu Ser Ala Pro Glu Val Tyr Ala Asn Cys Pro Gly Leu Leu 
65                  70                  75                  80  


Gly Glu Arg Ala Leu Ser Lys Gly Leu Gln His Glu Pro Ala Gly Val 
                85                  90                  95      


Ser Gly Ser Phe Pro Arg Asp Pro Gly Gly Leu Asp Glu Val Ala Met 
            100                 105                 110         


Gly Glu Met Glu Ala Asp Val Gln Ala Leu Val Arg Arg Ala Ala Arg 
        115                 120                 125             


Gln Leu Ala Glu Ser Gly Thr Pro Ser Leu Thr Ala Ala Val Leu His 
    130                 135                 140                 


Thr Ile His Val Leu Ser Ala Tyr Ala Ser Ile Gly Pro Leu Thr Gly 
145                 150                 155                 160 


Val Phe Arg Glu Thr Gly Ala Leu Asp Leu Leu Met His Met Leu Cys 
                165                 170                 175     


Asn Pro Glu Pro Gln Ile Arg Arg Ser Ala Gly Lys Met Leu Gln Ala 
            180                 185                 190         


Leu Ala Ala His Asp Ala Gly Ser Arg Ala His Val Leu Leu Ser Leu 
        195                 200                 205             


Ser Gln Gln Asp Gly Ile Glu Gln His Met Asp Phe Asp Ser Arg Tyr 
    210                 215                 220                 


Thr Leu Leu Glu Leu Phe Ala Glu Thr Thr Ser Ser Glu Glu His Cys 
225                 230                 235                 240 


Met Ala Phe Glu Gly Ile His Leu Pro Gln Ile Pro Gly Lys Leu Leu 
                245                 250                 255     


Phe Ser Leu Val Lys Arg Tyr Leu Cys Val Thr Ser Leu Leu Asp Gln 
            260                 265                 270         


Leu Asn Ser Ser Pro Glu Leu Gly Ala Gly Asp Gln Ser Ser Pro Cys 
        275                 280                 285             


Ala Thr Arg Glu Lys Ser Arg Gly Gln Arg Glu Leu Glu Phe Ser Met 
    290                 295                 300                 


Ala Val Gly Asn Leu Ile Ser Glu Leu Val Arg Ser Met Gly Trp Ala 
305                 310                 315                 320 


Arg Asn Leu Ser Glu Gln Gly Met Ser Pro Pro Arg Pro Thr Arg Ser 
                325                 330                 335     


Ile Phe Gln Pro Tyr Ile Ser Gly Pro Ser Leu Leu Leu Pro Thr Ile 
            340                 345                 350         


Val Thr Thr Pro Arg Arg Gln Gly Trp Val Phe Arg Gln Arg Ser Glu 
        355                 360                 365             


Phe Ser Ser Arg Ser Gly Tyr Gly Glu Tyr Val Gln Gln Thr Leu Gln 
    370                 375                 380                 


Pro Gly Met Arg Val Arg Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala 
385                 390                 395                 400 


Gly Asp Glu Gly Glu Phe Arg Gln Ser Asn Asn Gly Ile Pro Pro Val 
                405                 410                 415     


Gln Val Phe Trp Gln Ser Thr Gly Arg Thr Tyr Trp Val His Trp His 
            420                 425                 430         


Met Leu Glu Ile Leu Gly Pro Glu Glu Ala Thr Glu Asp Lys Ala Ser 
        435                 440                 445             


Ala Ala Val Glu Lys Gly Ala Gly Ala Thr Val Leu Gly Thr Ala Phe 
    450                 455                 460                 


Pro Ser Trp Asp Trp Asn Pro Met Asp Gly Leu Tyr Pro Leu Pro Tyr 
465                 470                 475                 480 


Leu Gln Pro Glu Pro Gln Lys Asn Glu Arg Val Gly Tyr Leu Thr Gln 
                485                 490                 495     


Ala Glu Trp Trp Glu Leu Leu Phe Phe Ile Lys Lys Leu Asp Leu Cys 
            500                 505                 510         


Glu Gln Gln Pro Ile Phe Gln Asn Leu Trp Lys Asn Leu Asp Glu Thr 
        515                 520                 525             


Leu Gly Glu Lys Ala Leu Gly Glu Ile Ser Val Ser Val Glu Met Ala 
    530                 535                 540                 


Glu Ser Leu Leu Gln Val Leu Ser Ser Arg Phe Glu Gly Ser Thr Leu 
545                 550                 555                 560 


Asn Asp Leu Leu Asn Ser Gln Ile Tyr Thr Lys Tyr Gly Leu Leu Ser 
                565                 570                 575     


Asn Glu Pro Ser Ser Ser Ser Thr Ser Arg Asn His Ser Cys Thr Pro 
            580                 585                 590         


Asp Pro Glu Glu Glu Ser Lys Ser Glu Ala Ser Phe Ser Glu Glu Glu 
        595                 600                 605             


Thr Glu Ser Leu Lys Ala Lys Ala Glu Ala Pro Lys Thr Glu Ala Glu 
    610                 615                 620                 


Pro Thr Lys Thr Arg Thr Glu Thr Pro Met Ala Gln Ser Asp Ser Gln 
625                 630                 635                 640 


Leu Phe Asn Gln Leu Leu Val Thr Glu Gly Met Thr Leu Pro Thr Glu 
                645                 650                 655     


Met Lys Glu Ala Ala Ser Glu Met Ala Arg Ala Leu Arg Gly Pro Gly 
            660                 665                 670         


Pro Arg Ser Ser Leu Asp Gln His Val Ala Ala Val Val Ala Thr Val 
        675                 680                 685             


Gln Ile Ser Ser Leu Asp Thr Asn Leu Gln Leu Ser Gly Leu Ser Ala 
    690                 695                 700                 


Leu Ser Gln Ala Val Glu Glu Val Thr Glu Arg Asp His Pro Leu Val 
705                 710                 715                 720 


Arg Pro Asp Arg Ser Leu Arg Glu Lys Leu Val Lys Met Leu Val Glu 
                725                 730                 735     


Leu Leu Thr Asn Gln Val Gly Glu Lys Met Val Val Val Gln Ala Leu 
            740                 745                 750         


Arg Leu Leu Tyr Leu Leu Met Thr Lys His Glu Trp Arg Pro Leu Phe 
        755                 760                 765             


Ala Arg Glu Gly Gly Ile Tyr Ala Val Leu Val Cys Met Gln Glu Tyr 
    770                 775                 780                 


Lys Thr Ser Val Leu Val Gln Gln Ala Gly Leu Ala Ala Leu Lys Met 
785                 790                 795                 800 


Leu Ala Val Ala Ser Ser Ser Glu Ile Pro Thr Phe Val Thr Gly Arg 
                805                 810                 815     


Asp Ser Ile His Ser Leu Phe Asp Ala Gln Met Thr Arg Glu Ile Phe 
            820                 825                 830         


Ala Ser Ile Asp Ser Ala Thr Arg Pro Gly Ser Glu Ser Leu Leu Leu 
        835                 840                 845             


Thr Val Pro Ala Ala Val Ile Leu Met Leu Asn Thr Glu Gly Cys Ser 
    850                 855                 860                 


Ser Ala Ala Arg Asn Gly Leu Leu Leu Leu Asn Leu Leu Leu Cys Asn 
865                 870                 875                 880 


His His Thr Leu Gly Asp Gln Ile Ile Thr Gln Glu Leu Arg Asp Thr 
                885                 890                 895     


Leu Phe Arg His Ser Gly Ile Ala Pro Arg Thr Glu Pro Met Pro Thr 
            900                 905                 910         


Thr Arg Thr Ile Leu Met Met Leu Leu Asn Arg Tyr Ser Glu Pro Pro 
        915                 920                 925             


Gly Ser Pro Glu Arg Ala Ala Leu Glu Thr Pro Ile Ile Gln Gly Gln 
    930                 935                 940                 


Asp Gly Ser Pro Glu Leu Leu Ile Arg Ser Leu Val Gly Gly Pro Ser 
945                 950                 955                 960 


Ala Glu Leu Leu Leu Asp Leu Glu Arg Val Leu Cys Arg Glu Gly Ser 
                965                 970                 975     


Pro Gly Gly Ala Val Arg Pro Leu Leu Lys Arg Leu Gln Gln Glu Thr 
            980                 985                 990         


Gln Pro Phe Leu Leu Leu Leu Arg  Thr Leu Asp Ala Pro  Gly Pro Asn 
        995                 1000                 1005             


Lys Thr  Leu Leu Leu Ser Val  Leu Arg Val Ile Thr  Arg Leu Leu 
    1010                 1015                 1020             


Asp Phe  Pro Glu Ala Met Val  Leu Pro Trp His Glu  Val Leu Glu 
    1025                 1030                 1035             


Pro Cys  Leu Asn Cys Leu Ser  Gly Pro Ser Ser Asp  Ser Glu Ile 
    1040                 1045                 1050             


Val Gln  Glu Leu Thr Cys Phe  Leu His Arg Leu Ala  Ser Met His 
    1055                 1060                 1065             


Lys Asp  Tyr Ala Val Val Leu  Cys Cys Leu Gly Ala  Lys Glu Ile 
    1070                 1075                 1080             


Leu Ser  Lys Val Leu Asp Lys  His Ser Ala Gln Leu  Leu Leu Gly 
    1085                 1090                 1095             


Cys Glu  Leu Arg Asp Leu Val  Thr Glu Cys Glu Lys  Tyr Ala Gln 
    1100                 1105                 1110             


Leu Tyr  Ser Asn Leu Thr Ser  Ser Ile Leu Ala Gly  Cys Ile Gln 
    1115                 1120                 1125             


Met Val  Leu Gly Gln Ile Glu  Asp His Arg Arg Thr  His Gln Pro 
    1130                 1135                 1140             


Ile Asn  Ile Pro Phe Phe Asp  Val Phe Leu Arg His  Leu Cys Gln 
    1145                 1150                 1155             


Gly Ser  Ser Val Glu Val Lys  Glu Asp Lys Cys Trp  Glu Lys Val 
    1160                 1165                 1170             


Glu Val  Ser Ser Asn Pro His  Arg Ala Ser Lys Leu  Thr Asp His 
    1175                 1180                 1185             


Asn Pro  Lys Thr Tyr Trp Glu  Ser Asn Gly Ser Thr  Gly Ser His 
    1190                 1195                 1200             


Tyr Ile  Thr Leu His Met His  Arg Gly Val Leu Val  Arg Gln Leu 
    1205                 1210                 1215             


Thr Leu  Leu Val Ala Ser Glu  Asp Ser Ser Tyr Met  Pro Ala Arg 
    1220                 1225                 1230             


Val Val  Val Phe Gly Gly Asp  Ser Thr Ser Cys Ile  Gly Thr Glu 
    1235                 1240                 1245             


Leu Asn  Thr Val Asn Val Met  Pro Ser Ala Ser Arg  Val Ile Leu 
    1250                 1255                 1260             


Leu Glu  Asn Leu Asn Arg Phe  Trp Pro Ile Ile Gln  Ile Arg Ile 
    1265                 1270                 1275             


Lys Arg  Cys Gln Gln Gly Gly  Ile Asp Thr Arg Val  Arg Gly Val 
    1280                 1285                 1290             


Glu Val  Leu Gly Pro Lys Pro  Thr Phe Trp Pro Leu  Phe Arg Glu 
    1295                 1300                 1305             


Gln Leu  Cys Arg Arg Thr Cys  Leu Phe Tyr Thr Ile  Arg Ala Gln 
    1310                 1315                 1320             


Ala Trp  Ser Arg Asp Ile Ala  Glu Asp His Arg Arg  Leu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Pro Arg Leu Asn Arg  Val Leu Arg His Glu  Gln Asn Phe 
    1340                 1345                 1350             


Ala Asp  Arg Phe Leu Pro Asp  Asp Glu Ala Ala Gln  Ala Leu Gly 
    1355                 1360                 1365             


Lys Thr  Cys Trp Glu Ala Leu  Val Ser Pro Leu Val  Gln Asn Ile 
    1370                 1375                 1380             


Thr Ser  Pro Asp Ala Glu Gly  Val Ser Ala Leu Gly  Trp Leu Leu 
    1385                 1390                 1395             


Asp Gln  Tyr Leu Glu Gln Arg  Glu Thr Ser Arg Asn  Pro Leu Ser 
    1400                 1405                 1410             


Arg Ala  Ala Ser Phe Ala Ser  Arg Val Arg Arg Leu  Cys His Leu 
    1415                 1420                 1425             


Leu Val  His Val Glu Pro Pro  Pro Gly Pro Ser Pro  Glu Pro Ser 
    1430                 1435                 1440             


Thr Arg  Pro Phe Ser Lys Asn  Ser Lys Gly Arg Asp  Arg Ser Pro 
    1445                 1450                 1455             


Ala Pro  Ser Pro Val Leu Pro  Ser Ser Ser Leu Arg  Asn Ile Thr 
    1460                 1465                 1470             


Gln Cys  Trp Leu Ser Val Val  Gln Glu Gln Val Ser  Arg Phe Leu 
    1475                 1480                 1485             


Ala Ala  Ala Trp Arg Ala Pro  Asp Phe Val Pro Arg  Tyr Cys Lys 
    1490                 1495                 1500             


Leu Tyr  Glu His Leu Gln Arg  Ala Gly Ser Glu Leu  Phe Gly Pro 
    1505                 1510                 1515             


Arg Ala  Ala Phe Met Leu Ala  Leu Arg Ser Gly Phe  Ser Gly Ala 
    1520                 1525                 1530             


Leu Leu  Gln Gln Ser Phe Leu  Thr Ala Ala His Met  Ser Glu Gln 
    1535                 1540                 1545             


Phe Ala  Arg Tyr Ile Asp Gln  Gln Ile Gln Gly Gly  Leu Ile Gly 
    1550                 1555                 1560             


Gly Ala  Pro Gly Val Glu Met  Leu Gly Gln Leu Gln  Arg His Leu 
    1565                 1570                 1575             


Glu Pro  Ile Met Val Leu Ser  Gly Leu Glu Leu Ala  Thr Thr Phe 
    1580                 1585                 1590             


Glu His  Phe Tyr Gln His Tyr  Met Ala Asp Arg Leu  Leu Ser Phe 
    1595                 1600                 1605             


Gly Ser  Ser Trp Leu Glu Gly  Ala Val Leu Glu Gln  Ile Gly Leu 
    1610                 1615                 1620             


Cys Phe  Pro Asn Arg Leu Pro  Gln Leu Met Leu Gln  Ser Leu Ser 
    1625                 1630                 1635             


Thr Ser  Glu Glu Leu Gln Arg  Gln Phe His Leu Phe  Gln Leu Gln 
    1640                 1645                 1650             


Arg Leu  Asp Lys Leu Phe Leu  Glu Gln Glu Asp Glu  Glu Glu Lys 
    1655                 1660                 1665             


Arg Leu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Glu  Glu Ala Glu 
    1670                 1675                 1680             


Lys Glu  Leu Phe Ile Glu Asp  Pro Ser Pro Ala Ile  Ser Ile Leu 
    1685                 1690                 1695             


Val Leu  Ser Pro Arg Cys Trp  Pro Val Ser Pro Leu  Cys Tyr Leu 
    1700                 1705                 1710             


Tyr His  Pro Arg Lys Cys Leu  Pro Thr Glu Phe Cys  Asp Ala Leu 
    1715                 1720                 1725             


Asp Arg  Phe Ser Ser Phe Tyr  Ser Gln Ser Gln Asn  His Pro Val 
    1730                 1735                 1740             


Leu Asp  Met Gly Pro His Arg  Arg Leu Gln Trp Thr  Trp Leu Gly 
    1745                 1750                 1755             


Arg Ala  Glu Leu Gln Phe Gly  Lys Gln Ile Leu His  Val Ser Thr 
    1760                 1765                 1770             


Val Gln  Met Trp Leu Leu Leu  Lys Phe Asn Gln Thr  Glu Glu Val 
    1775                 1780                 1785             


Ser Val  Glu Thr Leu Leu Lys  Asp Ser Asp Leu Ser  Pro Glu Leu 
    1790                 1795                 1800             


Leu Leu  Gln Ala Leu Val Pro  Leu Thr Ser Gly Asn  Gly Pro Leu 
    1805                 1810                 1815             


Thr Leu  His Glu Gly Gln Asp  Phe Pro His Gly Gly  Val Leu Arg 
    1820                 1825                 1830             


Leu His  Glu Pro Gly Pro Gln  Arg Ser Gly Glu Ala  Leu Trp Leu 
    1835                 1840                 1845             


Ile Pro  Pro Gln Ala Tyr Leu  Asn Val Glu Lys Asp  Glu Gly Arg 
    1850                 1855                 1860             


Thr Leu  Glu Gln Lys Arg Asn  Leu Leu Ser Cys Leu  Leu Val Arg 
    1865                 1870                 1875             


Ile Leu  Lys Ala His Gly Glu  Lys Gly Leu His Ile  Asp Gln Leu 
    1880                 1885                 1890             


Val Cys  Leu Val Leu Glu Ala  Trp Gln Lys Gly Pro  Asn Pro Pro 
    1895                 1900                 1905             


Gly Thr  Leu Gly His Thr Val  Ala Gly Gly Val Ala  Cys Thr Ser 
    1910                 1915                 1920             


Thr Asp  Val Leu Ser Cys Ile  Leu His Leu Leu Gly  Gln Gly Tyr 
    1925                 1930                 1935             


Val Lys  Arg Arg Asp Asp Arg  Pro Gln Ile Leu Met  Tyr Ala Ala 
    1940                 1945                 1950             


Pro Glu  Pro Met Gly Pro Cys  Arg Gly Gln Ala Asp  Val Pro Phe 
    1955                 1960                 1965             


Cys Gly  Ser Gln Ser Glu Thr  Ser Lys Pro Ser Pro  Glu Ala Val 
    1970                 1975                 1980             


Ala Thr  Leu Ala Ser Leu Gln  Leu Pro Ala Gly Arg  Thr Met Ser 
    1985                 1990                 1995             


Pro Gln  Glu Val Glu Gly Leu  Met Lys Gln Thr Val  Arg Gln Val 
    2000                 2005                 2010             


Gln Glu  Thr Leu Asn Leu Glu  Pro Asp Val Ala Gln  His Leu Leu 
    2015                 2020                 2025             


Ala His  Ser His Trp Gly Ala  Glu Gln Leu Leu Gln  Ser Tyr Ser 
    2030                 2035                 2040             


Glu Asp  Pro Glu Pro Leu Leu  Leu Ala Ala Gly Leu  Cys Val His 
    2045                 2050                 2055             


Gln Ala  Gln Ala Val Pro Val  Arg Pro Asp His Cys  Pro Val Cys 
    2060                 2065                 2070             


Val Ser  Pro Leu Gly Cys Asp  Asp Asp Leu Pro Ser  Leu Cys Cys 
    2075                 2080                 2085             


Met His  Tyr Cys Cys Lys Ser  Cys Trp Asn Glu Tyr  Leu Thr Thr 
    2090                 2095                 2100             


Arg Ile  Glu Gln Asn Leu Val  Leu Asn Cys Thr Cys  Pro Ile Ala 
    2105                 2110                 2115             


Asp Cys  Pro Ala Gln Pro Thr  Gly Ala Phe Ile Arg  Ala Ile Val 
    2120                 2125                 2130             


Ser Ser  Pro Glu Val Ile Ser  Lys Tyr Glu Lys Ala  Leu Leu Arg 
    2135                 2140                 2145             


Gly Tyr  Val Glu Ser Cys Ser  Asn Leu Thr Trp Cys  Thr Asn Pro 
    2150                 2155                 2160             


Gln Gly  Cys Asp Arg Ile Leu  Cys Arg Gln Gly Leu  Gly Cys Gly 
    2165                 2170                 2175             


Thr Thr  Cys Ser Lys Cys Gly  Trp Ala Ser Cys Phe  Asn Cys Ser 
    2180                 2185                 2190             


Phe Pro  Glu Ala His Tyr Pro  Ala Ser Cys Gly His  Met Ser Gln 
    2195                 2200                 2205             


Trp Val  Asp Asp Gly Gly Tyr  Tyr Asp Gly Met Ser  Val Glu Ala 
    2210                 2215                 2220             


Gln Ser  Lys His Leu Ala Lys  Leu Ile Ser Lys Arg  Cys Pro Ser 
    2225                 2230                 2235             


Cys Gln  Ala Pro Ile Glu Lys  Asn Glu Gly Cys Leu  His Met Thr 
    2240                 2245                 2250             


Cys Ala  Lys Cys Asn His Gly  Phe Cys Trp Arg Cys  Leu Lys Ser 
    2255                 2260                 2265             


Trp Lys  Pro Asn His Lys Asp  Tyr Tyr Asn Cys Ser  Ala Met Val 
    2270                 2275                 2280             


Ser Lys  Ala Ala Arg Gln Glu  Lys Arg Phe Gln Asp  Tyr Asn Glu 
    2285                 2290                 2295             


Arg Cys  Thr Phe His His Gln  Ala Arg Glu Phe Ala  Val Asn Leu 
    2300                 2305                 2310             


Arg Asn  Arg Val Ser Ala Ile  His Glu Val Pro Pro  Pro Arg Ser 
    2315                 2320                 2325             


Phe Thr  Phe Leu Asn Asp Ala  Cys Gln Gly Leu Glu  Gln Ala Arg 
    2330                 2335                 2340             


Lys Val  Leu Ala Tyr Ala Cys  Val Tyr Ser Phe Tyr  Ser Gln Asp 
    2345                 2350                 2355             


Ala Glu  Tyr Met Asp Val Val  Glu Gln Gln Thr Glu  Asn Leu Glu 
    2360                 2365                 2370             


Leu His  Thr Asn Ala Leu Gln  Ile Leu Leu Glu Glu  Thr Leu Leu 
    2375                 2380                 2385             


Arg Cys  Arg Asp Leu Ala Ser  Ser Leu Arg Leu Leu  Arg Ala Asp 
    2390                 2395                 2400             


Cys Leu  Ser Thr Gly Met Glu  Leu Leu Arg Arg Ile  Gln Glu Arg 
    2405                 2410                 2415             


Leu Leu  Ala Ile Leu Gln His  Ser Ala Gln Asp Phe  Arg Val Gly 
    2420                 2425                 2430             


Leu Gln  Ser Pro Ser Val Glu  Ala Trp Glu Ala Lys  Gly Pro Asn 
    2435                 2440                 2445             


Met Pro  Gly Ser Gln Pro Gln  Ala Ser Ser Gly Pro  Glu Ala Glu 
    2450                 2455                 2460             


Glu Glu  Glu Glu Asp Asp Glu  Asp Asp Val Pro Glu  Trp Gln Gln 
    2465                 2470                 2475             


Asp Glu  Phe Asp Glu Glu Leu  Asp Asn Asp Ser Phe  Ser Tyr Asp 
    2480                 2485                 2490             


Glu Ser  Glu Asn Leu Asp Gln  Glu Thr Phe Phe Phe  Gly Asp Glu 
    2495                 2500                 2505             


Glu Glu  Asp Glu Asp Glu Ala  Tyr Asp 
    2510                 2515         


<210> 4824
<211> 491
<212> PRT
<213> Homo sapiens

<400> 4824
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Asp Gly Glu 
        35                  40                  45              


Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys Ile Ser Glu 
    50                  55                  60                  


Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys His Asp Ile 
65                  70                  75                  80  


Thr Gln Val Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu Asp Arg Leu 
                85                  90                  95      


Glu Arg Leu Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu Glu Arg Glu 
            100                 105                 110         


Phe Arg Gln Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser Glu Lys Asn 
        115                 120                 125             


Asn Glu Cys His Glu Pro Glu Lys Ser Phe Ser Leu Asp Ser Thr Ile 
    130                 135                 140                 


Asp Ala Asp Gln Arg Val Leu Arg Ile Gln Asn Thr Asp Asp Asn Asp 
145                 150                 155                 160 


Lys Tyr Asp Met Ser Phe Asn Gln Asn Ser Ala Ser Gly Lys His Glu 
                165                 170                 175     


His Leu Asn Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys Lys Glu Ser 
            180                 185                 190         


Leu Met Asp Leu Ser His Leu Asn Lys Trp Glu Ser Ile Pro Asn Thr 
        195                 200                 205             


Glu Lys Ser Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe His Gln Ser 
    210                 215                 220                 


Ser Ala Leu Thr Arg His Gln Arg Ile His Thr Arg Glu Lys Pro Tyr 
225                 230                 235                 240 


Lys Cys Lys Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser Ser Leu Ser 
                245                 250                 255     


Arg His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Ala 
            260                 265                 270         


Ser Asp Lys Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser Pro Ser Ser 
        275                 280                 285             


Gly Ile Ile Gln His Lys Lys Ile His Thr Arg Ala Lys Ser Tyr Lys 
    290                 295                 300                 


Cys Ser Ser Cys Glu Arg Val Phe Ser Arg Ser Val His Leu Thr Gln 
305                 310                 315                 320 


His Gln Lys Ile His Lys Glu Met Pro Cys Lys Cys Thr Val Cys Gly 
                325                 330                 335     


Ser Asp Phe Cys His Thr Ser Tyr Leu Leu Glu His Gln Arg Val His 
            340                 345                 350         


His Glu Glu Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu Ala Tyr Ile 
        355                 360                 365             


Lys Gln Gln Gly Ile His Phe Arg Glu Lys Pro Tyr Thr Cys Ser Glu 
    370                 375                 380                 


Cys Gly Lys Asp Phe Arg Leu Asn Ser His Leu Ile Gln His Gln Arg 
385                 390                 395                 400 


Ile His Thr Gly Glu Lys Ala His Glu Cys Asn Glu Cys Gly Lys Ala 
                405                 410                 415     


Phe Ser Gln Thr Ser Cys Leu Ile Gln His His Lys Met His Arg Lys 
            420                 425                 430         


Glu Lys Ser Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe Ser His Ser 
        435                 440                 445             


Ser Asp Leu Ile Leu Gln Gln Glu Val Leu Thr Arg Gln Lys Ala Phe 
    450                 455                 460                 


Asp Cys Asp Val Trp Glu Lys Asn Ser Ser Gln Arg Ala His Leu Val 
465                 470                 475                 480 


Gln His Gln Ser Ile His Thr Lys Glu Asn Ser 
                485                 490     


<210> 4825
<211> 902
<212> PRT
<213> Homo sapiens

<400> 4825
Met Ser Glu Phe Arg Ile His His Asp Val Asn Glu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Arg Val His Gly Gly Asp Gly Ala Glu Val Tyr Ile Asp Leu Leu 
            20                  25                  30          


Gln Lys Asn Arg Thr Pro Tyr Val Thr Thr Thr Val Ser Ala His Ser 
        35                  40                  45              


Ala Lys Val Lys Ile Ala Glu Phe Ser Arg Thr Pro Glu Asp Phe Leu 
    50                  55                  60                  


Lys Lys Tyr Asp Glu Leu Lys Ser Lys Asn Thr Arg Asn Leu Asp Pro 
65                  70                  75                  80  


Leu Val Tyr Leu Leu Ser Lys Leu Thr Glu Asp Lys Glu Thr Leu Gln 
                85                  90                  95      


Tyr Leu Gln Gln Asn Ala Lys Glu Arg Ala Glu Leu Ala Ala Ala Ala 
            100                 105                 110         


Val Gly Ser Ser Thr Thr Ser Ile Asn Val Pro Ala Ala Ala Ser Lys 
        115                 120                 125             


Ile Ser Met Gln Glu Leu Glu Glu Leu Arg Lys Gln Leu Gly Ser Val 
    130                 135                 140                 


Ala Thr Gly Ser Thr Leu Gln Gln Ser Leu Glu Leu Lys Arg Lys Met 
145                 150                 155                 160 


Leu Arg Asp Lys Gln Asn Lys Lys Asn Ser Gly Gln His Leu Pro Ile 
                165                 170                 175     


Phe Pro Ala Trp Val Tyr Glu Arg Pro Ala Leu Ile Gly Asp Phe Leu 
            180                 185                 190         


Ile Gly Ala Gly Ile Ser Thr Asp Thr Ala Leu Pro Ile Gly Thr Leu 
        195                 200                 205             


Pro Leu Ala Ser Gln Glu Ser Ala Val Val Glu Asp Leu Leu Tyr Val 
    210                 215                 220                 


Leu Val Gly Val Asp Gly Arg Tyr Val Ser Ala Gln Pro Leu Ala Gly 
225                 230                 235                 240 


Arg Gln Ser Arg Thr Phe Leu Val Asp Pro Asn Leu Asp Leu Ser Ile 
                245                 250                 255     


Arg Glu Leu Val His Arg Ile Leu Pro Val Ala Ala Ser Tyr Ser Ala 
            260                 265                 270         


Val Thr Arg Phe Ile Glu Glu Lys Ser Ser Phe Glu Tyr Gly Gln Val 
        275                 280                 285             


Asn His Ala Leu Ala Ala Ala Met Arg Thr Leu Val Lys Glu His Leu 
    290                 295                 300                 


Ile Leu Val Ser Gln Leu Glu Gln Leu His Arg Gln Gly Leu Leu Ser 
305                 310                 315                 320 


Leu Gln Lys Leu Trp Phe Tyr Ile Gln Pro Ala Met Arg Thr Met Asp 
                325                 330                 335     


Ile Leu Ala Ser Leu Ala Thr Ser Val Asp Lys Gly Glu Cys Leu Gly 
            340                 345                 350         


Gly Ser Thr Leu Ser Leu Leu His Asp Arg Ser Phe Ser Tyr Thr Gly 
        355                 360                 365             


Asp Ser Gln Ala Gln Glu Leu Cys Leu Tyr Leu Thr Lys Ala Ala Ser 
    370                 375                 380                 


Ala Pro Tyr Phe Glu Val Leu Glu Lys Trp Ile Tyr Arg Gly Ile Ile 
385                 390                 395                 400 


His Asp Pro Tyr Ser Glu Phe Met Val Glu Glu His Glu Leu Arg Lys 
                405                 410                 415     


Glu Arg Ile Gln Glu Asp Tyr Asn Asp Lys Tyr Trp Asp Gln Arg Tyr 
            420                 425                 430         


Thr Ile Val Gln Gln Gln Ile Pro Ser Phe Leu Gln Lys Met Ala Asp 
        435                 440                 445             


Lys Ile Leu Ser Thr Gly Lys Tyr Leu Asn Val Val Arg Glu Cys Gly 
    450                 455                 460                 


His Asp Val Thr Cys Pro Val Ala Lys Glu Ile Ile Tyr Thr Leu Lys 
465                 470                 475                 480 


Glu Arg Ala Tyr Val Glu Gln Ile Glu Lys Ala Phe Asn Tyr Ala Ser 
                485                 490                 495     


Lys Val Leu Leu Asp Phe Leu Met Glu Glu Lys Glu Leu Val Ala His 
            500                 505                 510         


Leu Arg Ser Ile Lys Arg Tyr Phe Leu Met Asp Gln Gly Asp Phe Phe 
        515                 520                 525             


Val His Phe Met Asp Leu Ala Glu Glu Glu Leu Arg Lys Pro Val Glu 
    530                 535                 540                 


Asp Ile Thr Pro Pro Arg Leu Glu Ala Leu Leu Glu Leu Ala Leu Arg 
545                 550                 555                 560 


Met Ser Thr Ala Asn Thr Asp Pro Phe Lys Asp Asp Leu Lys Ile Asp 
                565                 570                 575     


Leu Met Pro His Asp Leu Ile Thr Gln Leu Leu Arg Val Leu Ala Ile 
            580                 585                 590         


Glu Thr Lys Gln Glu Lys Ala Met Ala His Ala Asp Pro Thr Glu Leu 
        595                 600                 605             


Ala Leu Ser Gly Leu Glu Ala Phe Ser Phe Asp Tyr Ile Val Lys Trp 
    610                 615                 620                 


Pro Leu Ser Leu Ile Ile Asn Arg Lys Ala Leu Thr Arg Tyr Gln Met 
625                 630                 635                 640 


Leu Phe Arg His Met Phe Tyr Cys Lys His Val Glu Arg Gln Leu Cys 
                645                 650                 655     


Ser Val Trp Ile Ser Asn Lys Thr Ala Lys Gln His Ser Leu His Ser 
            660                 665                 670         


Ala Gln Trp Phe Ala Gly Ala Phe Thr Leu Arg Gln Arg Met Leu Asn 
        675                 680                 685             


Phe Val Gln Asn Ile Gln Tyr Tyr Met Met Phe Glu Val Met Glu Pro 
    690                 695                 700                 


Thr Trp His Ile Leu Glu Lys Asn Leu Lys Ser Ala Ser Asn Ile Asp 
705                 710                 715                 720 


Asp Val Leu Gly His His Thr Gly Phe Leu Asp Thr Cys Leu Lys Asp 
                725                 730                 735     


Cys Met Leu Thr Asn Pro Glu Leu Leu Lys Val Phe Ser Lys Leu Met 
            740                 745                 750         


Ser Val Cys Val Met Phe Thr Asn Cys Met Gln Lys Phe Thr Gln Ser 
        755                 760                 765             


Met Lys Leu Asp Gly Glu Leu Gly Gly Gln Thr Leu Glu His Ser Thr 
    770                 775                 780                 


Val Leu Gly Leu Pro Ala Gly Ala Glu Glu Arg Ala Arg Lys Glu Leu 
785                 790                 795                 800 


Ala Arg Lys His Leu Ala Glu His Ala Asp Thr Val Gln Leu Val Ser 
                805                 810                 815     


Gly Phe Glu Ala Thr Ile Asn Lys Phe Asp Lys Asn Phe Ser Ala His 
            820                 825                 830         


Leu Leu Asp Leu Leu Ala Arg Leu Ser Ile Tyr Ser Thr Ser Asp Cys 
        835                 840                 845             


Glu His Gly Met Ala Ser Val Ile Ser Arg Leu Asp Phe Asn Gly Phe 
    850                 855                 860                 


Tyr Thr Glu Arg Leu Glu Arg Leu Ser Ala Glu Arg Ser Gln Lys Ala 
865                 870                 875                 880 


Thr Pro Gln Val Pro Val Leu Arg Gly Pro Pro Ala Pro Ala Pro Arg 
                885                 890                 895     


Val Ala Val Thr Ala Gln 
            900         


<210> 4826
<211> 762
<212> PRT
<213> Homo sapiens

<400> 4826
Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile Ser His Val Thr 
1               5                   10                  15      


Ser Pro Ser Ser Asp Val Ile Gln Lys Gly Ser Ser Leu Gly Thr Glu 
            20                  25                  30          


Trp Gln Thr Pro Val Ile Ser Glu Pro Phe Arg Ser Arg Phe Ser Arg 
        35                  40                  45              


Cys Ser Ser Val Ala Asp Ser Gly Asp Thr Ala Ile Gly Thr Ser Cys 
    50                  55                  60                  


Ser Asp Ile Ala Glu Asp Phe Cys Ser Ser Ser Gly Ser Pro Pro Phe 
65                  70                  75                  80  


Gln Pro Ile Lys Ser His Val Thr Ile Pro Thr Ala His Val Met Pro 
                85                  90                  95      


Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro Val Gly 
            100                 105                 110         


Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser Val Gly 
        115                 120                 125             


Met Thr Arg Asn Gly Asp Leu Gly Ala Met Lys His Ser Pro Gly Leu 
    130                 135                 140                 


Ser Arg Asp Leu Met Tyr Phe Ser Gly Ala Thr Gly Glu Asn Gly Ile 
145                 150                 155                 160 


Glu Gln Ser Trp Phe Pro Ala Val Gly His Glu Arg Gln Glu Glu Ala 
                165                 170                 175     


Arg Lys Phe Asp Ile Pro Ser Met Glu Ser Thr Leu Asn Gln Ser Ala 
            180                 185                 190         


Met Met Glu Thr Leu Tyr Ser Asp Pro His His Arg Val Arg Phe His 
        195                 200                 205             


Asn Pro Arg Thr Ser Thr Ser Lys Glu Leu Tyr Arg Val Leu Pro Glu 
    210                 215                 220                 


Ala Lys Lys Ala Pro Gly Ser Gly Ala Val Phe Glu Arg Asn Gly Pro 
225                 230                 235                 240 


His Ser Asn Ser Ser Gly Val Leu Pro Leu Gly Leu Gln Pro Ala Pro 
                245                 250                 255     


Gly Leu Ser Lys Pro Leu Pro Ser Gln Val Trp Gln Pro Ser Pro Asp 
            260                 265                 270         


Thr Trp His Pro Arg Glu Gln Ser Cys Glu Leu Ser Thr Cys Arg Gln 
        275                 280                 285             


Gln Leu Glu Leu Ile Arg Leu Gln Met Glu Gln Met Gln Leu Gln Asn 
    290                 295                 300                 


Gly Ala Ile Cys His His Pro Ala Ala Phe Gly Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Leu Glu Pro Ala Gln Trp Ile Ser Ile Leu Asn Ser Asn Glu His Leu 
                325                 330                 335     


Leu Lys Glu Lys Glu Leu Leu Ile Asp Lys Gln Arg Lys His Ile Ser 
            340                 345                 350         


Gln Leu Glu Gln Lys Val Arg Glu Ser Glu Leu Gln Val His Ser Ala 
        355                 360                 365             


Leu Leu Gly Arg Pro Ala Pro Phe Gly Asp Val Cys Leu Leu Arg Leu 
    370                 375                 380                 


Gln Glu Leu Gln Arg Glu Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln 
385                 390                 395                 400 


Lys Thr Glu Ala Leu Ser Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu 
                405                 410                 415     


Ser Ala Ser Glu Val Glu Val Gln Leu Ile Arg Glu Ser Leu Lys Val 
            420                 425                 430         


Ala Leu Gln Lys His Ser Glu Glu Val Lys Lys Gln Glu Glu Arg Val 
        435                 440                 445             


Lys Gly Arg Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys 
    450                 455                 460                 


Glu Ser Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu 
465                 470                 475                 480 


Arg Tyr Leu Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser 
                485                 490                 495     


Gln Gln Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys 
            500                 505                 510         


Val Thr Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg 
        515                 520                 525             


Glu Lys Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe 
    530                 535                 540                 


Ser Ser Ala Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr 
545                 550                 555                 560 


Ser Gly Glu Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr 
                565                 570                 575     


Asp Ser Leu Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln 
            580                 585                 590         


Leu Arg Ser Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu 
        595                 600                 605             


Gly Thr Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala 
    610                 615                 620                 


Leu Gln Gln Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln 
625                 630                 635                 640 


Asp Leu Ile Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala 
                645                 650                 655     


Gln Pro Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu 
            660                 665                 670         


Leu His Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys 
        675                 680                 685             


Ser Ile Val Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu 
    690                 695                 700                 


Leu Leu Gly Ile His Ser Ala Gln His Pro Glu Thr Gln Leu Asp Leu 
705                 710                 715                 720 


Gln Lys Pro Asp Val Ile Lys Arg Lys Leu Glu Glu Val Gln Gln Leu 
                725                 730                 735     


Arg Arg Asp Ile Glu Asp Leu Arg Thr Thr Met Ser Asp Arg Tyr Ala 
            740                 745                 750         


Gln Asp Met Gly Glu Asn Cys Val Thr Gln 
        755                 760         


<210> 4827
<211> 480
<212> PRT
<213> Homo sapiens

<400> 4827
Met Ile Val Ala Asp Ser Glu Cys Arg Ala Glu Leu Lys Asp Tyr Leu 
1               5                   10                  15      


Arg Phe Ala Pro Gly Gly Val Gly Asp Ser Gly Pro Gly Glu Glu Gln 
            20                  25                  30          


Arg Glu Ser Arg Ala Arg Arg Gly Pro Arg Gly Pro Ser Ala Phe Ile 
        35                  40                  45              


Pro Val Glu Glu Val Leu Arg Glu Gly Ala Glu Ser Leu Glu Gln His 
    50                  55                  60                  


Leu Gly Leu Glu Ala Leu Met Ser Ser Gly Arg Val Asp Asn Leu Ala 
65                  70                  75                  80  


Val Val Met Gly Leu His Pro Asp Tyr Phe Thr Ser Phe Trp Arg Leu 
                85                  90                  95      


His Tyr Leu Leu Leu His Thr Asp Gly Pro Leu Ala Ser Ser Trp Arg 
            100                 105                 110         


His Tyr Ile Ala Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu 
        115                 120                 125             


Val Gly Ser His Met Ala Glu Phe Leu Gln Thr Gly Gly Asp Pro Glu 
    130                 135                 140                 


Trp Leu Leu Gly Leu His Arg Ala Pro Glu Lys Leu Arg Lys Leu Ser 
145                 150                 155                 160 


Glu Ile Asn Lys Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu 
                165                 170                 175     


His Ile Gln Ala Leu Leu Lys Thr Gly Glu His Thr Trp Ser Leu Ala 
            180                 185                 190         


Glu Leu Ile Gln Ala Leu Val Leu Leu Thr His Cys His Ser Leu Ser 
        195                 200                 205             


Ser Phe Val Phe Gly Cys Gly Ile Leu Pro Glu Gly Asp Ala Asp Gly 
    210                 215                 220                 


Ser Pro Ala Pro Gln Ala Pro Thr Pro Pro Ser Glu Gln Ser Ser Pro 
225                 230                 235                 240 


Pro Ser Arg Asp Pro Leu Asn Asn Ser Gly Gly Phe Glu Ser Ala Arg 
                245                 250                 255     


Asp Val Glu Ala Leu Met Glu Arg Met Gln Gln Leu Gln Glu Ser Leu 
            260                 265                 270         


Leu Arg Asp Glu Gly Thr Ser Gln Glu Glu Met Glu Ser Arg Phe Glu 
        275                 280                 285             


Leu Glu Lys Ser Glu Ser Leu Leu Val Thr Pro Ser Ala Asp Ile Leu 
    290                 295                 300                 


Glu Pro Ser Pro His Pro Asp Met Leu Cys Phe Val Glu Asp Pro Thr 
305                 310                 315                 320 


Phe Gly Tyr Glu Asp Phe Thr Arg Arg Gly Ala Gln Ala Pro Pro Thr 
                325                 330                 335     


Phe Arg Ala Gln Asp Tyr Thr Trp Glu Asp His Gly Tyr Ser Leu Ile 
            340                 345                 350         


Gln Arg Leu Tyr Pro Glu Gly Gly Gln Leu Leu Asp Glu Lys Phe Gln 
        355                 360                 365             


Ala Ala Tyr Ser Leu Thr Tyr Asn Thr Ile Ala Met His Ser Gly Val 
    370                 375                 380                 


Asp Thr Ser Val Leu Arg Arg Ala Ile Trp Asn Tyr Ile His Cys Val 
385                 390                 395                 400 


Phe Gly Ile Arg Tyr Asp Asp Tyr Asp Tyr Gly Glu Val Asn Gln Leu 
                405                 410                 415     


Leu Glu Arg Asn Leu Lys Val Tyr Ile Lys Thr Val Ala Cys Tyr Pro 
            420                 425                 430         


Glu Lys Thr Thr Arg Arg Met Tyr Asn Leu Phe Trp Arg His Phe Arg 
        435                 440                 445             


His Ser Glu Lys Val His Val Asn Leu Leu Leu Leu Glu Ala Arg Met 
    450                 455                 460                 


Gln Ala Ala Leu Leu Tyr Ala Leu Arg Ala Ile Thr Arg Tyr Met Thr 
465                 470                 475                 480 


<210> 4828
<211> 210
<212> PRT
<213> Homo sapiens

<400> 4828
Met Pro Gly Val Lys Leu Thr Thr Gln Ala Tyr Cys Lys Met Val Leu 
1               5                   10                  15      


His Gly Ala Lys Tyr Pro His Cys Ala Val Asn Gly Leu Leu Val Ala 
            20                  25                  30          


Glu Lys Gln Lys Pro Arg Lys Glu His Leu Pro Leu Gly Gly Pro Gly 
        35                  40                  45              


Ala His His Thr Leu Phe Val Asp Cys Ile Pro Leu Phe His Gly Thr 
    50                  55                  60                  


Leu Ala Leu Ala Pro Met Leu Glu Val Ala Leu Thr Leu Ile Asp Ser 
65                  70                  75                  80  


Trp Cys Lys Asp His Ser Tyr Val Ile Ala Gly Tyr Tyr Gln Ala Asn 
                85                  90                  95      


Glu Arg Val Lys Asp Ala Ser Pro Asn Gln Val Ala Glu Lys Val Ala 
            100                 105                 110         


Ser Arg Ile Ala Glu Gly Phe Ser Asp Thr Ala Leu Ile Met Val Asp 
        115                 120                 125             


Asn Thr Lys Phe Thr Met Asp Cys Val Ala Pro Thr Ile His Val Tyr 
    130                 135                 140                 


Glu His His Glu Asn Arg Trp Arg Cys Arg Asp Pro His His Asp Tyr 
145                 150                 155                 160 


Cys Glu Asp Trp Pro Glu Ala Gln Arg Ile Ser Ala Ser Leu Leu Asp 
                165                 170                 175     


Ser Arg Ser Tyr Glu Thr Leu Val Asp Phe Asp Asn His Leu Asp Asp 
            180                 185                 190         


Ile Arg Asn Asp Trp Thr Asn Pro Glu Ile Asn Lys Ala Val Leu His 
        195                 200                 205             


Leu Cys 
    210 


<210> 4829
<211> 352
<212> PRT
<213> Homo sapiens

<400> 4829
Met Thr Glu Ala Gly Lys Leu Pro Leu Pro Leu Pro Pro Arg Leu Asp 
1               5                   10                  15      


Trp Phe Val His Thr Gln Met Gly Gln Leu Ala Gln Asp Gly Val Pro 
            20                  25                  30          


Glu Trp Phe His Gly Ala Ile Ser Arg Glu Asp Ala Glu Asn Leu Leu 
        35                  40                  45              


Glu Ser Gln Pro Leu Gly Ser Phe Leu Ile Arg Val Ser His Ser His 
    50                  55                  60                  


Val Gly Tyr Thr Leu Ser Tyr Lys Ala Gln Ser Ser Cys Cys His Phe 
65                  70                  75                  80  


Met Val Lys Leu Leu Asp Asp Gly Thr Phe Met Ile Pro Gly Glu Lys 
                85                  90                  95      


Val Ala His Thr Ser Leu Asp Ala Leu Val Thr Phe His Gln Gln Lys 
            100                 105                 110         


Pro Ile Glu Pro Arg Arg Glu Leu Leu Thr Gln Pro Cys Arg Gln Lys 
        115                 120                 125             


Asp Pro Ala Asn Val Asp Tyr Glu Asp Leu Phe Leu Tyr Ser Asn Ala 
    130                 135                 140                 


Val Ala Glu Glu Ala Ala Cys Pro Val Ser Ala Pro Glu Glu Ala Ser 
145                 150                 155                 160 


Pro Lys Pro Val Leu Cys His Gln Ser Lys Glu Arg Lys Pro Ser Ala 
                165                 170                 175     


Glu Met Asn Arg Ile Thr Thr Lys Glu Ala Thr Ser Ser Cys Pro Pro 
            180                 185                 190         


Lys Ser Pro Leu Gly Glu Thr Arg Gln Lys Leu Trp Arg Ser Leu Lys 
        195                 200                 205             


Met Leu Pro Glu Arg Gly Gln Arg Val Arg Gln Gln Leu Lys Ser His 
    210                 215                 220                 


Leu Ala Thr Val Asn Leu Ser Ser Leu Leu Asp Val Arg Arg Ser Thr 
225                 230                 235                 240 


Val Ile Ser Gly Pro Gly Thr Gly Lys Gly Ser Gln Asp His Ser Gly 
                245                 250                 255     


Asp Pro Thr Ser Gly Asp Arg Gly Tyr Thr Asp Pro Cys Val Ala Thr 
            260                 265                 270         


Ser Leu Lys Ser Pro Ser Gln Pro Gln Ala Pro Lys Asp Arg Lys Val 
        275                 280                 285             


Pro Thr Arg Lys Ala Glu Arg Ser Val Ser Cys Ile Glu Val Thr Pro 
    290                 295                 300                 


Gly Asp Arg Ser Trp His Gln Met Val Val Arg Ala Leu Ser Ser Gln 
305                 310                 315                 320 


Glu Ser Lys Pro Glu His Gln Gly Leu Ala Glu Pro Glu Asn Asp Gln 
                325                 330                 335     


Leu Pro Glu Glu Tyr Gln Gln Pro Pro Pro Phe Ala Pro Gly Tyr Cys 
            340                 345                 350         


<210> 4830
<211> 159
<212> PRT
<213> Homo sapiens

<400> 4830
Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys Arg Thr 
1               5                   10                  15      


Thr Cys Trp Lys Pro Thr Thr Val Thr Thr Cys Ser Ser Thr Pro Cys 
            20                  25                  30          


Cys Gln Pro Ser Cys Cys Val Ser Ser Cys Cys Gln Pro Cys Cys Arg 
        35                  40                  45              


Pro Thr Cys Cys Gln Asn Thr Cys Cys Gln Pro Ile Cys Val Thr Ser 
    50                  55                  60                  


Cys Cys Gln Pro Ser Cys Cys Ser Thr Pro Cys Cys Gln Pro Thr Cys 
65                  70                  75                  80  


Cys Gly Gln Thr Ser Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser Cys 
                85                  90                  95      


Ala Pro Val Tyr Cys Arg Arg Thr Cys Tyr His Pro Thr Thr Val Cys 
            100                 105                 110         


Leu Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Asn Cys Cys Gln Pro 
        115                 120                 125             


Cys Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr Cys 
    130                 135                 140                 


Phe Gln Pro Thr Cys Val Ser Ser Cys Cys Gln Pro Ser Cys Cys 
145                 150                 155                 


<210> 4831
<211> 204
<212> PRT
<213> Homo sapiens

<400> 4831
Met Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro 
1               5                   10                  15      


Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu 
        35                  40                  45              


Glu Glu Ala Ser Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu 
    50                  55                  60                  


Lys Ser Lys Arg Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys 
65                  70                  75                  80  


Ala Val Gln Arg Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu 
                85                  90                  95      


Asn Glu Asn Gln Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg 
            100                 105                 110         


Glu Leu Gly Tyr Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val 
    130                 135                 140                 


Ile Arg Gln Ser Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Trp Glu Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly 
                165                 170                 175     


Gly Ser Glu Asp Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu 
            180                 185                 190         


Glu Pro Gln Arg Pro Ser Pro Ser Glu Pro Gly Thr 
        195                 200                 


<210> 4832
<211> 686
<212> PRT
<213> Homo sapiens

<400> 4832
Met Thr Asp Ala Leu Leu Pro Ala Ala Pro Gln Pro Leu Glu Lys Glu 
1               5                   10                  15      


Asn Asp Gly Tyr Phe Arg Lys Gly Cys Asn Pro Leu Ala Gln Thr Gly 
            20                  25                  30          


Arg Ser Lys Leu Gln Asn Gln Arg Ala Ala Leu Asn Gln Gln Ile Leu 
        35                  40                  45              


Lys Ala Val Arg Met Arg Thr Gly Ala Glu Asn Leu Leu Lys Val Ala 
    50                  55                  60                  


Thr Asn Ser Lys Val Arg Glu Gln Val Arg Leu Glu Leu Ser Phe Val 
65                  70                  75                  80  


Asn Ser Asp Leu Gln Met Leu Lys Glu Glu Leu Glu Gly Leu Asn Ile 
                85                  90                  95      


Ser Val Gly Val Tyr Gln Asn Thr Glu Glu Ala Phe Thr Ile Pro Leu 
            100                 105                 110         


Ile Pro Leu Gly Leu Lys Glu Thr Lys Asp Val Asp Phe Ala Val Val 
        115                 120                 125             


Leu Lys Asp Phe Ile Leu Glu His Tyr Ser Glu Asp Gly Tyr Leu Tyr 
    130                 135                 140                 


Glu Asp Glu Ile Ala Asp Leu Met Asp Leu Arg Gln Ala Cys Arg Thr 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Ala Gly Val Glu Leu Leu Met Thr Tyr Phe Ile 
                165                 170                 175     


Gln Leu Gly Phe Val Glu Ser Arg Phe Phe Pro Pro Thr Arg Gln Met 
            180                 185                 190         


Gly Leu Leu Phe Thr Trp Tyr Asp Ser Leu Thr Gly Val Pro Val Ser 
        195                 200                 205             


Gln Gln Asn Leu Leu Leu Glu Lys Ala Ser Val Leu Phe Asn Thr Gly 
    210                 215                 220                 


Ala Leu Tyr Thr Gln Ile Gly Thr Arg Cys Asp Arg Gln Thr Gln Ala 
225                 230                 235                 240 


Gly Leu Glu Ser Ala Ile Asp Ala Phe Gln Arg Ala Ala Gly Val Leu 
                245                 250                 255     


Asn Tyr Leu Lys Asp Thr Phe Thr His Thr Pro Ser Tyr Asp Met Ser 
            260                 265                 270         


Pro Ala Met Leu Ser Val Leu Val Lys Met Met Leu Ala Gln Ala Gln 
        275                 280                 285             


Glu Ser Val Phe Glu Lys Ile Ser Leu Pro Gly Ile Arg Asn Glu Phe 
    290                 295                 300                 


Phe Met Leu Val Lys Val Ala Gln Glu Ala Ala Lys Val Gly Glu Val 
305                 310                 315                 320 


Tyr Gln Gln Leu His Ala Ala Met Ser Gln Ala Pro Val Lys Glu Asn 
                325                 330                 335     


Ile Pro Tyr Ser Trp Ala Ser Leu Ala Cys Val Lys Ala His His Tyr 
            340                 345                 350         


Ala Ala Leu Ala His Tyr Phe Thr Ala Ile Leu Leu Ile Asp His Gln 
        355                 360                 365             


Val Lys Pro Gly Thr Asp Leu Asp His Gln Glu Lys Cys Leu Ser Gln 
    370                 375                 380                 


Leu Tyr Asp His Met Pro Glu Gly Leu Thr Pro Leu Ala Thr Leu Lys 
385                 390                 395                 400 


Asn Asp Gln Gln Arg Arg Gln Leu Gly Lys Ser His Leu Arg Arg Ala 
                405                 410                 415     


Met Ala His His Glu Glu Ser Val Arg Glu Ala Ser Leu Cys Lys Lys 
            420                 425                 430         


Leu Arg Ser Ile Glu Val Leu Gln Lys Val Leu Cys Ala Ala Gln Glu 
        435                 440                 445             


Arg Ser Arg Leu Thr Tyr Ala Gln His Gln Glu Glu Asp Asp Leu Leu 
    450                 455                 460                 


Asn Leu Ile Asp Ala Pro Ser Val Val Ala Lys Thr Glu Gln Glu Val 
465                 470                 475                 480 


Asp Ile Ile Leu Pro Gln Phe Ser Lys Leu Thr Val Thr Asp Phe Phe 
                485                 490                 495     


Gln Lys Leu Gly Pro Leu Ser Val Phe Ser Ala Asn Lys Arg Trp Thr 
            500                 505                 510         


Pro Pro Arg Ser Ile Arg Phe Thr Ala Glu Glu Gly Asp Leu Gly Phe 
        515                 520                 525             


Thr Leu Arg Gly Asn Ala Pro Val Gln Val His Phe Leu Asp Pro Tyr 
    530                 535                 540                 


Cys Ser Ala Ser Val Ala Gly Ala Arg Glu Gly Asp Tyr Ile Val Ser 
545                 550                 555                 560 


Ile Gln Leu Val Asp Cys Lys Trp Leu Thr Leu Ser Glu Val Met Lys 
                565                 570                 575     


Leu Leu Lys Ser Phe Gly Glu Asp Glu Ile Glu Met Lys Val Val Ser 
            580                 585                 590         


Leu Leu Asp Ser Thr Ser Ser Met His Asn Lys Ser Ala Thr Tyr Ser 
        595                 600                 605             


Val Gly Met Gln Lys Thr Tyr Ser Met Ile Cys Leu Ala Ile Asp Asp 
    610                 615                 620                 


Asp Asp Lys Thr Asp Lys Thr Lys Lys Ile Ser Lys Lys Leu Ser Phe 
625                 630                 635                 640 


Leu Ser Trp Gly Thr Asn Lys Asn Arg Gln Lys Ser Ala Ser Thr Leu 
                645                 650                 655     


Cys Leu Pro Ser Val Gly Ala Ala Arg Pro Gln Val Lys Lys Lys Leu 
            660                 665                 670         


Pro Ser Pro Phe Ser Leu Leu Asn Ser Asp Ser Ser Trp Tyr 
        675                 680                 685     


<210> 4833
<211> 417
<212> PRT
<213> Homo sapiens

<400> 4833
Met Pro Leu Tyr Glu Gly Leu Gly Ser Gly Gly Glu Lys Thr Ala Val 
1               5                   10                  15      


Val Ile Asp Leu Gly Glu Ala Phe Thr Lys Cys Gly Phe Ala Gly Glu 
            20                  25                  30          


Thr Gly Pro Arg Cys Ile Ile Pro Ser Val Ile Lys Arg Ala Gly Met 
        35                  40                  45              


Pro Lys Pro Val Arg Val Val Gln Tyr Asn Ile Asn Thr Glu Glu Leu 
    50                  55                  60                  


Tyr Ser Tyr Leu Lys Glu Phe Ile His Ile Leu Tyr Phe Arg His Leu 
65                  70                  75                  80  


Leu Val Asn Pro Arg Asp Arg Arg Val Val Ile Ile Glu Ser Val Leu 
                85                  90                  95      


Cys Pro Ser His Phe Arg Glu Thr Leu Thr Arg Val Leu Phe Lys Tyr 
            100                 105                 110         


Phe Glu Val Pro Ser Val Leu Leu Ala Pro Ser His Leu Met Ala Leu 
        115                 120                 125             


Leu Thr Leu Gly Ile Asn Ser Ala Met Val Leu Asp Cys Gly Tyr Arg 
    130                 135                 140                 


Glu Ser Leu Val Leu Pro Ile Tyr Glu Gly Ile Pro Val Leu Asn Cys 
145                 150                 155                 160 


Trp Gly Ala Leu Pro Leu Gly Gly Lys Ala Leu His Lys Glu Leu Glu 
                165                 170                 175     


Thr Gln Leu Leu Glu Gln Cys Thr Val Asp Thr Ser Val Ala Lys Glu 
            180                 185                 190         


Gln Ser Leu Pro Ser Val Met Gly Ser Val Pro Glu Gly Val Leu Glu 
        195                 200                 205             


Asp Ile Lys Ala Arg Thr Cys Phe Val Ser Asp Leu Lys Arg Gly Leu 
    210                 215                 220                 


Lys Ile Gln Ala Ala Lys Phe Asn Ile Asp Gly Asn Asn Glu Arg Pro 
225                 230                 235                 240 


Ser Pro Pro Pro Asn Val Asp Tyr Pro Leu Asp Gly Glu Lys Ile Leu 
                245                 250                 255     


His Ile Leu Gly Ser Ile Arg Asp Ser Val Val Glu Ile Leu Phe Glu 
            260                 265                 270         


Gln Asp Asn Glu Glu Gln Ser Val Ala Thr Leu Ile Leu Asp Ser Leu 
        275                 280                 285             


Ile Gln Cys Pro Ile Asp Thr Arg Lys Gln Leu Ala Glu Asn Leu Val 
    290                 295                 300                 


Val Ile Gly Gly Thr Ser Met Leu Pro Gly Phe Leu His Arg Leu Leu 
305                 310                 315                 320 


Ala Glu Ile Arg Tyr Leu Val Glu Lys Pro Lys Tyr Lys Lys Ala Leu 
                325                 330                 335     


Gly Thr Lys Thr Phe Arg Ile His Thr Pro Pro Ala Lys Ala Asn Cys 
            340                 345                 350         


Val Ala Trp Leu Gly Gly Ala Ile Phe Gly Ala Leu Gln Asp Ile Leu 
        355                 360                 365             


Gly Ser Arg Ser Val Ser Lys Glu Tyr Tyr Asn Gln Thr Gly Arg Ile 
    370                 375                 380                 


Pro Asp Trp Cys Ser Leu Asn Asn Pro Pro Leu Glu Met Met Phe Asp 
385                 390                 395                 400 


Val Gly Lys Thr Gln Pro Pro Leu Met Lys Arg Ala Phe Ser Thr Glu 
                405                 410                 415     


Lys 
    


<210> 4834
<211> 880
<212> PRT
<213> Homo sapiens

<400> 4834
Met Ser Gln Pro Ala Gly Gly Arg Arg Lys Pro Arg Thr Leu Gly Pro 
1               5                   10                  15      


Pro Val Cys Ser Ile Arg Pro Phe Lys Ser Ser Glu Gln Tyr Leu Glu 
            20                  25                  30          


Ala Met Lys Glu Asp Leu Ala Glu Trp Leu Arg Asp Leu Tyr Gly Leu 
        35                  40                  45              


Asp Ile Asp Ala Ala Asn Phe Leu Gln Val Leu Glu Thr Gly Leu Val 
    50                  55                  60                  


Leu Cys Gln His Ala Asn Val Val Thr Asp Ala Ala Leu Ala Phe Leu 
65                  70                  75                  80  


Ala Glu Ala Pro Ala Gln Ala Gln Lys Ile Pro Met Pro Arg Val Gly 
                85                  90                  95      


Val Ser Cys Asn Gly Ala Ala Gln Pro Gly Thr Phe Gln Ala Arg Asp 
            100                 105                 110         


Asn Val Ser Asn Phe Ile Gln Trp Cys Arg Lys Glu Met Gly Ile Gln 
        115                 120                 125             


Glu Val Leu Met Phe Glu Thr Glu Asp Leu Val Leu Arg Lys Asn Val 
    130                 135                 140                 


Lys Asn Val Val Leu Cys Leu Leu Glu Leu Gly Arg Arg Ala Trp Arg 
145                 150                 155                 160 


Phe Gly Val Ala Ala Pro Thr Leu Val Gln Leu Glu Glu Glu Ile Glu 
                165                 170                 175     


Glu Glu Val Arg Arg Glu Leu Ala Leu Pro Pro Pro Asp Pro Ser Pro 
            180                 185                 190         


Pro Ala Pro Pro Arg Arg Gln Pro Cys His Phe Arg Asn Leu Asp Gln 
        195                 200                 205             


Met Val Gln Ser Leu Val Ser His Cys Thr Cys Pro Val Gln Phe Ser 
    210                 215                 220                 


Met Val Lys Val Ser Glu Gly Lys Tyr Arg Val Gly Asp Ser Asn Thr 
225                 230                 235                 240 


Leu Ile Phe Ile Arg Ile Leu Arg Asn His Val Met Val Arg Val Gly 
                245                 250                 255     


Gly Gly Trp Asp Thr Leu Gly His Tyr Leu Asp Lys His Asp Pro Cys 
            260                 265                 270         


Arg Cys Thr Ser Leu Ser His Lys Pro Gly Ser Phe Leu Lys Pro Pro 
        275                 280                 285             


Ala Pro Pro Val Gln His Glu Val Arg Val Gln Asp Gly Pro Ser Gln 
    290                 295                 300                 


Thr Gln Pro Thr Met Thr Ile Ser Arg Ser Gln Ser Pro Pro Pro Pro 
305                 310                 315                 320 


Val Asp Trp Lys Thr Tyr Thr Ser Ser Asp Arg Arg Leu Arg Pro Pro 
                325                 330                 335     


Thr Pro Ser Ser Pro Arg Pro Arg Arg Glu Arg Gly Ala Gly Thr Gly 
            340                 345                 350         


Ala Ser Arg Glu Met Ala Pro Phe Leu Arg Cys Gln Glu Arg Ser Leu 
        355                 360                 365             


Ile Pro Ser Trp Arg Gln Pro Thr Ala Gly Asp Ser Pro Pro Ser Pro 
    370                 375                 380                 


Gln Ser Ser Ser Thr Gln Lys Gly Arg Asp Pro Gln Cys Thr Ser Ser 
385                 390                 395                 400 


Gly Lys Arg Glu Glu Arg Tyr Pro Pro Glu Leu Pro Arg Gly Arg Ile 
                405                 410                 415     


Pro Thr Ser Trp Val His Glu Glu Thr Asp Ser Trp Gly Thr Asp Ala 
            420                 425                 430         


Gly Asn Pro Thr Pro Gln Arg Leu Arg Ala Ile Glu Ala Thr Thr Lys 
        435                 440                 445             


Gly Ile Ser Ala Arg Gly Pro Ser Pro Leu Pro Arg Ser Phe Gly Pro 
    450                 455                 460                 


Ala Glu Cys Leu Gly Leu Arg Leu Pro Leu Arg Asp Glu Ala Lys Gly 
465                 470                 475                 480 


Ala Phe Phe Gln Phe Arg Glu Pro Glu Ser Val Arg Ser Pro Thr Pro 
                485                 490                 495     


Val Gln Gly Leu Thr Lys Ile Pro Ile Arg Leu Pro Pro Ala Arg Pro 
            500                 505                 510         


Pro Thr Pro Gly Arg Ser Phe Pro Gly Ala Thr Ser Gly Ser Pro Arg 
        515                 520                 525             


Thr Glu Leu Gly Arg Asp Pro Ile Pro Leu Arg Ala Val Thr Val Asp 
    530                 535                 540                 


Leu Ala Gly Ser Thr His Gly Asp Cys Ser Val Glu Val Arg Gln Glu 
545                 550                 555                 560 


Asp Gln Gln Leu Asp Ile Gln Val Met Ala Glu Ala Arg Glu Ser Trp 
                565                 570                 575     


Asp Leu Gly Leu Gln Glu Gln Glu Gly Arg Tyr Thr Pro Leu Pro Leu 
            580                 585                 590         


Gly Gly Asn Lys Glu Gln Ala Ile Tyr Cys Ser Leu Glu Glu Glu Ile 
        595                 600                 605             


Leu Gly Asn Met Lys Leu Leu Glu Val Arg Ser Ala Cys Pro Gln Gly 
    610                 615                 620                 


Thr Arg Ser Gly Val Ile Pro Arg Ser Gly Val Tyr Ile Pro Arg Leu 
625                 630                 635                 640 


Ala Gly Gln Trp Pro Glu Pro Gly Gly Pro Tyr Asp Lys Ala Ile Gln 
                645                 650                 655     


Glu Leu Ala Gln Gly Ser Pro Ser Leu Leu Lys Val Asp Leu Glu Ala 
            660                 665                 670         


Trp Lys Ala Ala Pro Thr Gly Ser Pro Lys Pro Ala Val Thr Pro Gly 
        675                 680                 685             


Pro Gly Ser Leu Lys Gly Lys Leu Gly Ala Arg Gln Ser Gly Pro Arg 
    690                 695                 700                 


Thr Lys Ala Ser Leu Ser Ala Lys Gly Thr His Met Arg Lys Val Pro 
705                 710                 715                 720 


Pro Gln Gly Gly Gln Asp Cys Ser Ala Ser Thr Val Ser Ala Ser Pro 
                725                 730                 735     


Glu Ala Pro Thr Pro Ser Pro Leu Asp Pro Asn Ser Asp Lys Ala Lys 
            740                 745                 750         


Ala Cys Leu Ser Lys Gly Arg Arg Thr Leu Arg Lys Pro Lys Arg Val 
        755                 760                 765             


Pro Ser Ile Tyr Lys Leu Lys Leu Arg Pro Arg Ile Arg Pro Arg Arg 
    770                 775                 780                 


Asp His Arg Pro Glu Lys Gln Pro Ser Arg Ile Pro Arg Pro Leu Ala 
785                 790                 795                 800 


Tyr Val Phe Leu Gly Pro Ala Arg Gln Pro Pro Lys Asp Arg Leu Leu 
                805                 810                 815     


Arg Ala Val Leu Gly Ser Lys Gly Gly Glu Ala Ser Arg Val Asp Gly 
            820                 825                 830         


Ala Ser Val Gly Glu Glu Glu Glu Glu Gly Lys Glu Glu Lys Glu Pro 
        835                 840                 845             


Ala Ala Pro Leu Glu Ser Ser Pro Gln Pro Pro Glu Gly Leu Gln Pro 
    850                 855                 860                 


His Trp Leu Asn Gln Ala Pro Leu Pro Pro Glu Glu Glu Ser Trp Val 
865                 870                 875                 880 


<210> 4835
<211> 4753
<212> PRT
<213> Homo sapiens

<400> 4835
Met Val Pro Glu Glu Arg Arg Val Gly Leu Ser Ser Asp Glu Thr Ser 
1               5                   10                  15      


Ser Asp Ser Leu Lys Ser Trp His Ser Ile Cys Val Leu Asp Ser Lys 
            20                  25                  30          


Glu Gln Pro Leu Ala Cys Gln Gln Lys Gln Arg Gln Phe Val Lys Pro 
        35                  40                  45              


Val Thr Glu Ser Glu Gln Pro Thr Val Leu Glu Leu Leu Leu Ala Glu 
    50                  55                  60                  


Leu Arg Thr Leu Phe Ser Ala Val Leu Gln Asp Ser Ser Pro Ala Ala 
65                  70                  75                  80  


Trp Arg Tyr Leu His Ala Val Leu Gly Leu Leu Pro Pro Tyr Arg Glu 
                85                  90                  95      


Leu Leu Val Gly His Leu Asp Leu Leu Pro Phe Leu Glu Gln Leu Tyr 
            100                 105                 110         


Cys Trp Ala Pro Trp Val Gln Thr His Leu His Leu Asp Leu Leu Gly 
        115                 120                 125             


Ala Ile Val Gln Ala Phe Pro Pro Asp Ser Ser Leu Leu Asp Ser Ala 
    130                 135                 140                 


Ser His Ala Asp Cys Cys Pro Gln Lys Arg Arg Leu His His Arg Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Cys Pro Phe Val Gln Ala Gln Trp Ser Arg Gln Gln 
                165                 170                 175     


Val Lys Glu Glu Leu Ala Thr Trp Leu Arg Pro Leu Thr Leu Pro Glu 
            180                 185                 190         


Leu Gln Arg Cys Leu Gly Ile Val Gly Ala Gln Val Ala Leu Glu Glu 
        195                 200                 205             


Ala Val Trp Leu Asp Gly Leu Ser Leu Leu Pro Leu Ala Leu Ala Ala 
    210                 215                 220                 


Asp Ile Pro Val Arg Tyr Glu Ser Ser Asp Thr Asp Asn Ala Glu Val 
225                 230                 235                 240 


Glu Pro Val Gly Arg Lys Glu Thr Arg Ser Gln Leu Asp Tyr Glu Val 
                245                 250                 255     


Pro Arg Glu Lys Ala Phe Gln Lys Ser Ser Thr Gly Phe Ser Pro Glu 
            260                 265                 270         


Thr Ser Phe Leu Asp Ser Gln Val Met Thr Ala Leu Lys Met Glu Arg 
        275                 280                 285             


Tyr Leu Lys Lys Ile His Phe Leu Tyr Leu Asn Val Ala Pro Ser Arg 
    290                 295                 300                 


Tyr Phe Arg Pro Tyr Ser Leu Met Val Val Pro Pro Asp Lys Val Asn 
305                 310                 315                 320 


Pro Glu His Tyr Ile Phe Ser Pro Phe Gly Ile Leu His Val His Pro 
                325                 330                 335     


Val Glu Gly Ser Glu Thr Met Thr Leu Gly Thr Trp His His His Cys 
            340                 345                 350         


Val Leu Trp Gln Gln Leu Gln Phe Ile Pro Phe Phe Lys Tyr Cys Leu 
        355                 360                 365             


Leu Arg Lys Ser Phe Thr Cys Trp Lys Lys Asn Val Arg Leu Gln Gly 
    370                 375                 380                 


Leu His Arg Leu Gln Lys Phe Leu Glu Asn His Leu Leu Leu Ala Val 
385                 390                 395                 400 


Pro His Phe Gly Ala Gly Leu Leu His Ile Ser Arg Leu Leu Gln Glu 
                405                 410                 415     


Leu His Ser Val Ser Trp Leu Pro Gln Glu Leu Asp Arg Cys Tyr Glu 
            420                 425                 430         


Leu Leu Asp Leu Gln Thr Ala Leu Ala Glu Glu Lys His Lys Ala Leu 
        435                 440                 445             


Arg Leu Leu His Arg Cys Leu Asn Leu Cys Thr Ser Ile Leu Arg Leu 
    450                 455                 460                 


Val His Glu Asp Thr Tyr His Met Gln Gln Cys Leu Gln Glu Arg Val 
465                 470                 475                 480 


Gln Asn Cys Asp Arg Ile Arg Thr Gly Gln Gly Ser Ile Tyr Leu Gln 
                485                 490                 495     


Arg Val Gln His Lys Gln Leu Glu Gln Lys Leu Lys Gln Ala Glu Ala 
            500                 505                 510         


Trp Trp Leu Gln Leu Gly Lys Phe Ala Arg Leu Val Asp Tyr Met Ile 
        515                 520                 525             


Cys Gln Ser Leu Ile Ser Val Leu Glu Glu Gln Ile Thr Ser Phe Val 
    530                 535                 540                 


Ala Asn Ile Leu Gln Ala Pro Arg Gln Lys Pro Phe Leu Ser Ser Gln 
545                 550                 555                 560 


Leu Val Phe Asp Asp His Gly Gln Leu Ser His Val Pro Cys Val Glu 
                565                 570                 575     


Asn Met Ile Gln Thr Leu Thr Gly Gly Leu Gln Ser Val Lys Thr Ser 
            580                 585                 590         


Ala Leu Gln Val Val Gln Ser Ala Asp Leu Lys Thr Ser Ser Asp Ser 
        595                 600                 605             


Leu Tyr Ser Glu Glu Glu Asp Glu Glu Glu Asp Ser Lys Asp Glu Phe 
    610                 615                 620                 


Leu Met Pro Lys Phe Gln Gly Gln Pro Ser Asp Ala Val Ser Ile Phe 
625                 630                 635                 640 


Cys Gly Pro Asn Val Gly Leu Val Trp Pro Trp Lys Ser His Pro Ile 
                645                 650                 655     


Ala Gly Ile Leu Glu Val Arg Gly Cys Arg Leu Arg Gly Gln Tyr Phe 
            660                 665                 670         


Pro His Asn Tyr Lys Gln Leu Glu Glu Asp Leu Asp Asn Asn Pro Lys 
        675                 680                 685             


Ile Gln Gln Ala Leu Asn Ile Gln Gln Val Leu Leu Glu Gly Val Leu 
    690                 695                 700                 


Cys Lys Val Gln Glu Phe Cys Arg Glu His His Trp Ile Thr Gly Ile 
705                 710                 715                 720 


Tyr Glu Phe Leu Gln Ser Trp Gly Pro Gln Lys Leu Glu Asp Met Arg 
                725                 730                 735     


Gly Gly Pro Ile Lys Asn Tyr Val Thr Leu Val Ser Arg Leu Asn Val 
            740                 745                 750         


Trp Gln Ala Arg Val Ser Ser Met Pro Ile Glu Leu Leu Thr Lys Gly 
        755                 760                 765             


Gly Leu Leu Leu Leu Ser Cys His Asp Val Gln Ala Glu Met Glu Ser 
    770                 775                 780                 


Lys Leu Asn Ser Ile Arg Lys Asp Ile Leu Ala His Val Gln Asn Glu 
785                 790                 795                 800 


Cys Trp Asn Leu Ser Gln Gln Leu Met Thr Glu Leu Thr Asp Phe Met 
                805                 810                 815     


His Ile Phe Arg Thr Ile Asn Ser Asp Ile His Ala Ile Ala Gln Cys 
            820                 825                 830         


Thr Gln Lys Leu Asn Glu Ala Asn Glu Gln Tyr Val Glu Leu Glu Glu 
        835                 840                 845             


Arg Met Glu Tyr Val Arg Ala Leu His Glu Leu Ile Arg Asn His Phe 
    850                 855                 860                 


Ser Leu Phe Ser Ala Glu Asn Glu Ala Leu Asp Ile Ser Val Arg Arg 
865                 870                 875                 880 


Gln Phe Gly Glu Ser Pro Ile Pro Pro Cys Pro Pro Pro Pro Gln Pro 
                885                 890                 895     


His Leu Leu His Cys Pro Leu Leu Ala Pro Gln Leu Leu Asp Met Trp 
            900                 905                 910         


Glu Ala Phe Gln Phe Glu Lys Ser Gln Ala Ser Glu Phe Leu Leu Ser 
        915                 920                 925             


Lys Arg His Ala Ile Met Pro Lys Leu Gln Gln Leu Met Ala Ala Ala 
    930                 935                 940                 


Leu Ala Glu Leu Glu Gly Leu Leu Ala Lys Ala Leu Ser Gly Pro Phe 
945                 950                 955                 960 


Met Asp Pro Thr Gln Asp Gln Arg Ser Thr Glu His Gln Leu Val Ser 
                965                 970                 975     


Leu Glu Arg Gln Phe Gln Asn Thr Val Ser Asp Leu Ser Glu Leu His 
            980                 985                 990         


His Ala Tyr Ala Ile Phe Thr Glu  Asp Glu Thr Pro Val  Pro Leu Pro 
        995                 1000                 1005             


Ile Cys  Gly Thr Arg Pro Ile  Val Gln Gln Gln Arg  Ile Trp His 
    1010                 1015                 1020             


Leu Tyr  Arg Val Ile Ser Glu  Asn Ile Ser Glu Trp  Lys Cys Met 
    1025                 1030                 1035             


Ala Phe  Ala Lys Phe Ser Pro  Ala Met Ala Gln Glu  Lys Thr Glu 
    1040                 1045                 1050             


Gly Trp  Leu Thr Glu Ala Ala  Arg Met Ser Thr Thr  Leu Glu Leu 
    1055                 1060                 1065             


His Ser  Pro Val Leu Gln His  Cys Met Arg Ile Leu  Gly Glu Phe 
    1070                 1075                 1080             


Arg Ser  Tyr Leu Pro Leu Leu  Thr Lys Leu Gly Ser  Leu His Pro 
    1085                 1090                 1095             


Gln Ser  Leu Asn Cys Gln Cys  Leu Leu Arg Ala Leu  Gly Leu Gly 
    1100                 1105                 1110             


Ser Leu  Gln Thr Ile Glu Leu  Leu Thr Leu Gly Gln  Leu Leu Thr 
    1115                 1120                 1125             


Tyr Pro  Leu Leu Glu Phe Ala  Asp Arg Ile Asn Gln  Val Trp Gln 
    1130                 1135                 1140             


Asn Glu  Asn Glu Arg Ile His  Ala Gln Glu Thr Ile  Arg Arg Leu 
    1145                 1150                 1155             


Gln Arg  Tyr Trp Glu Ala Arg  Gln Leu Arg Leu Leu  Asn Phe Ile 
    1160                 1165                 1170             


Leu His  Val Pro Tyr Glu Pro  Pro Ala Ser Glu Arg  Ser Lys Arg 
    1175                 1180                 1185             


Gln Val  Leu Arg Ser Pro Gln  Trp Glu Val Val Asp  Lys Asp Ser 
    1190                 1195                 1200             


Gly Thr  Phe Ile Leu Ser Asp  Tyr Ser Asn Leu Gln  Asp Ser Ile 
    1205                 1210                 1215             


Gln Glu  Ser Leu Gln Val Leu  Ser Lys Ile Leu Ala  Ile Glu Lys 
    1220                 1225                 1230             


Ser Gly  Asp Leu Asn Lys Ile  Ala Leu Glu Trp Val  Ala Ile Met 
    1235                 1240                 1245             


His Gly  Leu Gly Ala Leu Leu  Glu Val Trp Leu Thr  Phe Gln Gln 
    1250                 1255                 1260             


Lys Trp  Ile Phe Leu Asn Lys  Val Leu His Glu Met  Lys Ile Gln 
    1265                 1270                 1275             


Phe Pro  Asn Ala Asp Leu Asn  Ser Arg Phe Lys Val  Met Asp Asp 
    1280                 1285                 1290             


Gln Tyr  Arg Thr Leu Met Arg  Ile Ser Val Ala Asp  Pro Met Val 
    1295                 1300                 1305             


Leu Ser  Leu Val Val Pro Ser  Ala Glu Arg Ser Pro  Tyr Phe Gln 
    1310                 1315                 1320             


Gly Gln  Gln Leu Gln Gln Leu  Leu Gln Ala Gly Ser  Val Glu Leu 
    1325                 1330                 1335             


Glu Gly  Ile Ile Met Ser Leu  Glu Ser Val Leu Tyr  Gly Val Cys 
    1340                 1345                 1350             


Ala His  Phe Pro Arg Leu Phe  Phe Leu Ser Asp Ser  Glu Leu Val 
    1355                 1360                 1365             


Ala Leu  Leu Ala Ala Arg Leu  Glu Ser Cys Glu Ala  Gln Leu Trp 
    1370                 1375                 1380             


Val Arg  Arg Cys Phe Pro His  Val His Ala Val Ser  Phe Arg Ser 
    1385                 1390                 1395             


Cys Pro  Thr Gly Glu Lys Asn  Thr Asp Asp Trp Glu  Ser Ser Pro 
    1400                 1405                 1410             


Asn Thr  Gln Thr Gln Val Glu  Ala Leu Ala Val Leu  Gly Ala Gly 
    1415                 1420                 1425             


Gly Glu  Glu Val Lys Leu Gln  Gly Pro Leu Pro Leu  His Pro Asp 
    1430                 1435                 1440             


Leu Pro  Lys Trp Leu Ala Ser  Leu Glu Lys Cys Leu  Arg Leu Ala 
    1445                 1450                 1455             


Leu Val  His Met Leu Gln Gly  Cys Val Ala Ala Arg  Leu Ala Arg 
    1460                 1465                 1470             


Gly Pro  Ser Leu Gly Glu Ala  Leu Lys Gln Leu Pro  Lys Gln Asn 
    1475                 1480                 1485             


Lys Leu  Tyr Leu Gln Leu Tyr  Val Gln His Trp Ile  Asp Leu Val 
    1490                 1495                 1500             


Gln Ala  Phe Pro Trp Gln Cys  Val Leu Val Ala Glu  Glu Val Val 
    1505                 1510                 1515             


Trp Arg  Ala Glu Met Glu Glu  Ala Leu Leu Glu Trp  Gly Thr Leu 
    1520                 1525                 1530             


Ala Met  Val Ser Met His Met  Arg Lys Leu Glu Val  Leu Val Asn 
    1535                 1540                 1545             


Phe Met  Arg Ala Gln Arg Ala  Ser Gln Gly Gly Gln  Ser Leu Pro 
    1550                 1555                 1560             


Ser Val  Arg Gln Thr Ser Leu  Leu Ser Ala Leu Leu  Val Met Ala 
    1565                 1570                 1575             


Val Thr  His Arg Asp Ile Ala  Gln Leu Leu Glu Gln  His Gln Val 
    1580                 1585                 1590             


Ser Asp  Leu Thr Asp Phe His  Trp Val Arg Gln Leu  Lys Tyr His 
    1595                 1600                 1605             


Leu Gly  Ser Pro His Ile Ile  Pro Lys Ser Pro Leu  Gln Ser Leu 
    1610                 1615                 1620             


Lys Thr  Ile Ala Ser Ser Glu  Pro Ser Leu Ser Pro  Ala Ala Cys 
    1625                 1630                 1635             


Trp Ile  Asp Val Leu Gly Arg  Ser Phe Leu Tyr Asn  Tyr Glu Tyr 
    1640                 1645                 1650             


Leu Gly  Pro Arg Leu Gly Pro  Leu Pro Ser Leu Leu  Pro Glu Arg 
    1655                 1660                 1665             


Pro Ala  Leu Val Leu Leu Leu  Ala Leu Glu Glu Val  Ala Cys Gly 
    1670                 1675                 1680             


Thr Val  Leu Gly Pro Asn Gly  Val Gly Lys Arg Ala  Ile Val Asn 
    1685                 1690                 1695             


Ser Leu  Ala Gln Ala Leu Gly  Arg Gln Leu Val Met  Leu Pro Cys 
    1700                 1705                 1710             


Ser Pro  Gln Ile Glu Ala Gln  Cys Leu Ser Asn Tyr  Leu Asn Gly 
    1715                 1720                 1725             


Ala Leu  Gln Gly Gly Ala Trp  Leu Leu Leu Glu Lys  Val His Gln 
    1730                 1735                 1740             


Leu Pro  Pro Gly Leu Leu Ser  Ala Leu Gly Gln Arg  Leu Gly Glu 
    1745                 1750                 1755             


Leu His  His Leu Tyr Ala Pro  Leu Tyr Gln Glu Ala  Ser Arg Asn 
    1760                 1765                 1770             


Thr Ser  Thr Ile Asp Pro Thr  Gln Pro Gln Leu Leu  Gly Ser Ser 
    1775                 1780                 1785             


Phe Phe  Glu Lys His His Val  Ser Val Arg Leu Gly  Tyr Gly Cys 
    1790                 1795                 1800             


Leu Leu  Val Leu Arg Ala Leu  Ser Ser Ala Val Pro  Ala Asn Leu 
    1805                 1810                 1815             


His Leu  Leu Leu Arg Pro Val  Ala Leu Ala Leu Pro  Asp Leu Arg 
    1820                 1825                 1830             


Gln Val  Ala Glu Leu Thr Leu  Leu Gly Ala Gly Met  Arg Asp Ala 
    1835                 1840                 1845             


Phe Gln  Met Ala Thr Arg Leu  Ser Lys Phe Phe Ser  Leu Glu Arg 
    1850                 1855                 1860             


Glu Leu  Val Ser Gly Pro Leu  Pro Cys Arg Leu Pro  Leu Leu Lys 
    1865                 1870                 1875             


Gln Ile  Leu Glu Asp Thr Ile  Arg Thr Leu Asn Val  Thr Lys Glu 
    1880                 1885                 1890             


Glu Pro  Lys Cys Gln Lys Pro  Arg Ser Leu Ala Ala  Ile Glu Glu 
    1895                 1900                 1905             


Ala Ala  Leu Leu Arg Ser Pro  Leu Phe Ser Ile Leu  Asn Gly Leu 
    1910                 1915                 1920             


His Leu  His Asn Leu Arg Gly  Leu Leu Cys Ala Leu  Phe Pro Ser 
    1925                 1930                 1935             


Ala Ser  Gln Val Leu Ala Glu  Pro Met Thr Tyr Lys  Leu Met Lys 
    1940                 1945                 1950             


Pro Leu  Val Val Glu Glu Leu  Gln Gln Val Gly Leu  Asp Pro Ser 
    1955                 1960                 1965             


Pro Asp  Ile Leu Gly Ser Leu  Glu Gln Leu Ser Gln  Ala Leu Ser 
    1970                 1975                 1980             


Arg Ala  Ser Gly Ile Leu Leu  Leu Gly Pro Ala Gly  Ser Gly Lys 
    1985                 1990                 1995             


Thr Thr  Cys Trp His Ser Leu  Phe Lys Ile Gln Asn  Arg Leu Ala 
    2000                 2005                 2010             


Ala Met  Glu Asp Thr Ser Thr  Gln Gly Cys Gln Pro  Val Glu Ile 
    2015                 2020                 2025             


Thr His  Leu Tyr Pro Ser Gly  Leu Ser Pro Gln Glu  Phe Leu Gly 
    2030                 2035                 2040             


Trp Leu  Glu Gly Ser Cys Trp  His His Gly Ile Phe  Pro Lys Val 
    2045                 2050                 2055             


Leu Arg  Ala Ala Gly Gln Cys  Asn Asn Met Gly Gln  Lys Arg Gln 
    2060                 2065                 2070             


Thr Glu  Glu Ser Ile Gly Ile  Gln His Trp Ile Ile  Cys Asp Gly 
    2075                 2080                 2085             


Ala Ser  Asn Gly Ala Trp Leu  Asp Ser Ile Thr Cys  Leu Leu Ser 
    2090                 2095                 2100             


Glu Leu  Pro Gln Leu Ser Leu  Pro Ser Gly Gln Gln  Ile Ala Arg 
    2105                 2110                 2115             


Pro Pro  Gly Thr Phe Leu Leu  Met Glu Val Ala Asp  Thr Thr Gly 
    2120                 2125                 2130             


Ile Ser  Pro Thr Val Val Gly  Cys Cys Ala Leu Val  Trp Cys Gly 
    2135                 2140                 2145             


Gly Glu  Gln Thr Trp Gln Cys  Ile Leu Ser Ala Leu  Met Ala Ser 
    2150                 2155                 2160             


Leu Pro  Tyr Glu Tyr Arg Leu  Gln His Arg Thr Val  Ala Glu Leu 
    2165                 2170                 2175             


Asn His  Met Ala Glu Val Leu  Val Pro Ala Thr Leu  Arg Phe Leu 
    2180                 2185                 2190             


Thr Cys  Gln Gly Val Ser Ser  Leu Leu Gln Val His  Gly Gln Gln 
    2195                 2200                 2205             


Ala Val  Cys Ala Gly Val Ala  Glu Val Thr Ser Met  Ala Arg Ile 
    2210                 2215                 2220             


Leu His  Ser Leu Leu Asp Leu  His Leu Arg Leu Lys  Glu Glu Lys 
    2225                 2230                 2235             


Ala Pro  Gly Pro Glu Asp Leu  Ser Tyr Ser Asp Pro  Val Ala Gln 
    2240                 2245                 2250             


Ser Phe  Arg Ser Ser Lys Ser  Ser Phe Leu Asn Arg  Ser Gln Val 
    2255                 2260                 2265             


Asp Ser  Asp Asp Val Pro Asp  Lys Cys Arg Glu His  Leu Leu Ala 
    2270                 2275                 2280             


Val Ser  Ser Phe Leu Phe Ala  Leu Ile Trp Gly Phe  Gly Ala His 
    2285                 2290                 2295             


Leu Pro  Ser Arg Phe Trp Pro  Ile Phe Asp Thr Phe  Ile Arg Asp 
    2300                 2305                 2310             


Ser Ile  Ser Arg Leu Ser Asn  Tyr Pro Glu Pro Pro  Pro Ser Ala 
    2315                 2320                 2325             


Leu Val  Phe Asp Leu His Val  Ser Pro Glu Asp Gly  Thr Leu Val 
    2330                 2335                 2340             


Pro Phe  Thr Gly Gln Tyr Leu  Ser Ser His Ile Lys  Gly Thr Leu 
    2345                 2350                 2355             


Gly Thr  Phe His Pro Ser Ile  Gln Thr Glu Arg Leu  Leu Tyr Val 
    2360                 2365                 2370             


Val Asp  Leu Leu Leu Ser Gly  Gly Gln Pro Val Leu  Leu Ala Gly 
    2375                 2380                 2385             


Glu Ala  Ala Thr Gly Lys Ser  Ala Phe Val Glu Val  Leu Val Glu 
    2390                 2395                 2400             


Pro His  His Pro Tyr Ile Tyr  Ser Pro Ile His Pro  Ala Phe Ser 
    2405                 2410                 2415             


Ser Ser  His Leu Arg Leu Leu  Leu Ser Arg Gly Ile  Gln Gly Gln 
    2420                 2425                 2430             


Thr Gln  Ala Ser Pro Gln Pro  Gly His His Gln Asp  Ser Lys Pro 
    2435                 2440                 2445             


Ser Leu  Leu Phe Leu Leu Glu  Asp Leu His Leu Ala  Thr Ser Asp 
    2450                 2455                 2460             


Pro Glu  Lys Ser Cys Gln Pro  Val Leu Glu Thr Leu  Arg Gln Ala 
    2465                 2470                 2475             


Met Asp  Gly Thr Val Tyr Ala  His Ser Thr Leu Glu  Leu Gln Thr 
    2480                 2485                 2490             


Leu Gln  Pro Thr Val Asn Phe  Leu Ala Thr Val Thr  Val Pro Gly 
    2495                 2500                 2505             


Tyr Cys  Glu Arg Pro Leu Cys  Pro Arg Leu Phe Arg  Leu Phe Thr 
    2510                 2515                 2520             


Val Leu  Ala Leu Glu Ser Met  Thr Gln Ala Thr Leu  Leu Glu Arg 
    2525                 2530                 2535             


His Val  Pro Ile Ile Gln Ala  Trp Leu Glu Arg Phe  Pro Ser Val 
    2540                 2545                 2550             


Glu Arg  Glu Arg Ala Leu Ala  Arg Gly Leu Val Arg  Ala Ser Val 
    2555                 2560                 2565             


Glu Ala  Trp Glu Ala Val Cys  Asn Cys Phe Met Pro  Ser Pro Leu 
    2570                 2575                 2580             


His Pro  His Tyr His Phe Ser  Leu His Ser Val Ser  His Leu Leu 
    2585                 2590                 2595             


Ser Ser  Leu Gln Leu Leu Pro  Asn Arg Thr Gly Ser  Arg Gly Phe 
    2600                 2605                 2610             


Val Asp  Tyr Pro Asn His Gln  Glu His Leu Arg Arg  Val Ser Gly 
    2615                 2620                 2625             


Leu Arg  Gly Thr Cys Leu Thr  Val Met Met Ala Thr  Arg Asn Val 
    2630                 2635                 2640             


Val Arg  Leu Trp Leu His Glu  Ala Gln Arg Thr Phe  Cys Asp Arg 
    2645                 2650                 2655             


Leu Asp  Ser Pro Arg Glu Arg  Ser Tyr Cys Ala Lys  Leu Leu Leu 
    2660                 2665                 2670             


Val Val  Ala Gln Ser Val Phe  Cys Cys Gly Pro Gly  Pro Gln His 
    2675                 2680                 2685             


Leu Gly  Lys Asp His Gln Glu  Ser Glu Glu Glu Glu  Glu Glu Glu 
    2690                 2695                 2700             


Arg Val  Pro Glu Val Glu Ser  Glu Gly Glu Leu Ala  Gln Trp Glu 
    2705                 2710                 2715             


Asp Phe  Ser Asn Ser Asn Ser  Glu Thr Glu Glu Glu  Glu Glu Pro 
    2720                 2725                 2730             


Tyr Gly  Leu Gln Val Ala Arg  Val Ser Asn Ser Arg  Asp Pro Ser 
    2735                 2740                 2745             


Leu Thr  Pro Ser Ile Gly Pro  Val Ser Arg Gly Met  Lys Glu Ser 
    2750                 2755                 2760             


Ile Ser  His Lys Ile Arg Gln  Glu Lys Gly Thr Arg  Ala Ser Asn 
    2765                 2770                 2775             


Tyr Arg  Leu Gln Val Arg Arg  Ser Phe Lys Thr Trp  Trp Gln Lys 
    2780                 2785                 2790             


Lys Pro  Gln Met Asp Leu Ile  Ser Pro Leu Leu Leu  Pro Val Leu 
    2795                 2800                 2805             


Leu Leu  His Pro Gln Glu Lys  Pro Ser Asp Leu Val  Phe Ser Gln 
    2810                 2815                 2820             


Glu Leu  Ile Leu Gly Pro Asn  Ser Glu Thr Pro Asn  Leu Tyr Leu 
    2825                 2830                 2835             


Glu Arg  Gln Trp Glu Lys Leu  Glu Glu Gln Leu Ala  Thr Ser Ala 
    2840                 2845                 2850             


Ala Gln  Leu Lys Leu Ser Pro  His Leu Ala Arg Cys  His Ser Met 
    2855                 2860                 2865             


Ala Gln  His Val Ala Arg Leu  Val Arg Val Leu Ala  Arg Pro Arg 
    2870                 2875                 2880             


Gln His  Gly Leu Leu Leu Ser  Gly Ala Leu Gly Thr  Gly Arg His 
    2885                 2890                 2895             


Thr Ala  Ile Thr Leu Ala Ser  Ser Ile Cys Gln Ala  His Phe Phe 
    2900                 2905                 2910             


His Leu  Pro Ser Gly Ser Glu  Glu Ala Ile Leu Gln  Cys Leu Arg 
    2915                 2920                 2925             


Asp Ala  Ser Trp His Ala Gly  Met Leu Ser Gln Pro  Val Ala Leu 
    2930                 2935                 2940             


Leu Val  Pro Ser Gly Val Asp  Leu Thr Thr Leu His  Arg Leu Leu 
    2945                 2950                 2955             


Ala Leu  Ala Thr Ser Gly Ser  Phe Pro Gly Gln Tyr  Thr Glu Ala 
    2960                 2965                 2970             


Asp Leu  Asp Arg Ile Gly Glu  His Leu Pro Arg Glu  Asn Leu Gly 
    2975                 2980                 2985             


Val Lys  Gln Asn Ile Lys Lys  Glu Met Val Leu Gln  Arg Phe His 
    2990                 2995                 3000             


Gln Gln  Val Cys Ser His Leu  His Leu Phe Phe Leu  Ile Gly Asp 
    3005                 3010                 3015             


Lys Gln  Ala His Lys Gln Leu  Pro Ser Thr Leu Phe  Leu Arg Leu 
    3020                 3025                 3030             


Leu Gln  Leu Ala Thr Ala Ser  Ile Asp Arg Tyr Glu  Pro Trp Asp 
    3035                 3040                 3045             


Gln Ala  Ala Leu Ala Lys Val  Ala Gln His His Leu  Glu Gly Ala 
    3050                 3055                 3060             


Gln Ser  Val Pro Leu Asp Asp  Gly Ser Trp Lys Tyr  Pro Asp Leu 
    3065                 3070                 3075             


Gln Ala  Ser Ile Pro Ser Val  Ala Lys Ala Met Ala  Leu Ile His 
    3080                 3085                 3090             


Leu Ser  Ala Thr His Tyr His  Glu His Leu Cys Pro  Ala Leu Pro 
    3095                 3100                 3105             


Leu Val  Thr Pro Lys Thr Phe  Leu Asp Phe Leu Asp  Thr Phe Leu 
    3110                 3115                 3120             


Met Leu  Gln Gln Gln Thr Ile  Leu Lys Ile Lys Asn  Lys Ala Gln 
    3125                 3130                 3135             


Arg Val  Gln Asn Ala Leu Glu  Asn Leu Arg Met Leu  Ile Lys Glu 
    3140                 3145                 3150             


His Gly  Thr His Ala Asn Leu  Ile Phe Asp Leu Glu  Gln Gln Leu 
    3155                 3160                 3165             


Lys Asp  Ser Gly Lys Ser Leu  Ser Met Phe Gln Gln  Gln Leu Glu 
    3170                 3175                 3180             


Gln Ser  Lys Leu Leu Tyr Lys  Gln Gln Leu Glu Glu  Cys Arg His 
    3185                 3190                 3195             


Gln Glu  Asn Leu Ile Glu Asn  Leu Ala Arg Gln Arg  Asp Ala Leu 
    3200                 3205                 3210             


Gln Ala  Gln Arg Glu Ala Phe  Leu Glu Gln Met Ser  Lys Ala Phe 
    3215                 3220                 3225             


Leu Glu  Pro Leu Ser Gln Leu  Gln Val Ala Asp Phe  Glu Glu Ile 
    3230                 3235                 3240             


Arg Ser  Tyr Arg Ala Pro Pro  Glu Ser Val Val Arg  Val Thr Asp 
    3245                 3250                 3255             


Ala Met  Cys Asp Leu Phe His  His Glu Thr Gly Trp  Ala Ser Ala 
    3260                 3265                 3270             


Lys Gln  Leu Leu Cys Thr Glu  Asp Phe Tyr Gln Glu  Leu Val Phe 
    3275                 3280                 3285             


Phe Pro  Lys Glu Lys Ile Thr  Asp Ser Glu Leu Ile  Lys Leu His 
    3290                 3295                 3300             


Leu Ile  Leu Lys Ala Pro Gly  Met Asp Asp Ala Ala  Leu Arg Ala 
    3305                 3310                 3315             


Val Ser  Arg Pro Ala Ala Ser  Leu Ala Ala Trp Leu  Trp Ala Val 
    3320                 3325                 3330             


Leu His  Tyr Gly Leu Ala His  Cys Arg Gly Leu Pro  Thr Asp Leu 
    3335                 3340                 3345             


Leu Leu  Gln Gln Val Glu Ala  Thr Leu Thr Arg Glu  Gln Ala Arg 
    3350                 3355                 3360             


Leu Gly  Tyr Tyr Gln Phe Gln  Ala Gln Glu Thr Leu  Glu His Asn 
    3365                 3370                 3375             


Leu Ala  Leu Ala Lys Met Val  Glu Asp Ala Gln Ala  Ser His Asn 
    3380                 3385                 3390             


Cys Val  Ala Lys Thr Leu Ser  Gln Ala Gln Cys Gly  Gln Tyr His 
    3395                 3400                 3405             


Lys Trp  Pro Met Lys Ala Ala  Leu Leu Thr Pro Met  Arg Ala Trp 
    3410                 3415                 3420             


Thr Thr  Gln Leu Gln Lys Leu  Lys Gly Arg Cys Met  Thr Val Phe 
    3425                 3430                 3435             


Gly Asp  Thr Leu Leu Cys Ser  Ala Ala Ile Ile Tyr  Leu Gly Pro 
    3440                 3445                 3450             


Phe Pro  Pro Leu Arg Arg Gln  Glu Leu Leu Asp Glu  Trp Leu Ala 
    3455                 3460                 3465             


Leu Cys  Arg Gly Phe Gln Glu  Ala Leu Gly Pro Asp  Asp Val Ala 
    3470                 3475                 3480             


Gln Ala  Leu Lys Arg Lys Gln  Lys Ser Val Ser Ile  Pro Pro Lys 
    3485                 3490                 3495             


Asn Pro  Leu Leu Ala Thr His  Ser Pro Phe Ser Ile  Leu Ser Leu 
    3500                 3505                 3510             


Leu Ser  Ser Glu Ser Glu Gln  Tyr Gln Trp Asp Gly  Asn Leu Lys 
    3515                 3520                 3525             


Pro Gln  Ala Lys Ser Ala His  Leu Ala Gly Leu Leu  Leu Arg Ser 
    3530                 3535                 3540             


Pro Thr  His Tyr Ser Ser Cys  Arg Trp Pro Leu Leu  Leu Asp Pro 
    3545                 3550                 3555             


Ser Asn  Glu Ala Leu Ile Trp  Leu Asp Pro Leu Pro  Leu Glu Glu 
    3560                 3565                 3570             


Asn Arg  Ser Phe Ala Pro Ala  Leu Thr Glu Gly Arg  Gly Lys Gly 
    3575                 3580                 3585             


Leu Met  Arg Asn Gln Lys Arg  Glu Ser Lys Thr Asp  Met Lys Glu 
    3590                 3595                 3600             


Glu Asp  Asp Glu Ser Glu Glu  Ser Asn Glu Ala Glu  Asp Gln Thr 
    3605                 3610                 3615             


Lys Glu  Gln Lys Ala Glu Glu  Arg Lys Asn Glu Gln  Glu Lys Glu 
    3620                 3625                 3630             


Gln Glu  Glu Asn Glu Glu Lys  Glu Glu Glu Lys Thr  Glu Ser Gln 
    3635                 3640                 3645             


Gly Ser  Lys Pro Ala Tyr Glu  Thr Gln Leu Pro Ser  Leu Pro Tyr 
    3650                 3655                 3660             


Leu Ser  Val Leu Ser Gly Ala  Asp Pro Glu Leu Gly  Ser Gln Leu 
    3665                 3670                 3675             


Gln Glu  Ala Ala Ala Cys Gly  Leu Pro Val Leu Leu  Thr Asn Val 
    3680                 3685                 3690             


Glu Leu  Gly Leu Gly Cys Glu  Glu Leu Gln Trp Leu  Leu Gln Arg 
    3695                 3700                 3705             


Glu Gln  Leu Ser Pro Pro Gln  Val Gln Pro Gly Phe  Cys Leu Tyr 
    3710                 3715                 3720             


Leu Ser  Thr Thr Leu Ser Leu  Cys Ala Met Glu Lys  Val Leu Gly 
    3725                 3730                 3735             


Cys Glu  Leu Leu Lys Gly Leu  Asn Val Leu Asp Leu  Gly Leu Asn 
    3740                 3745                 3750             


Met Glu  Ile Leu Glu Glu Gln  Met Leu His Glu Ile  Leu Cys Arg 
    3755                 3760                 3765             


Glu Tyr  Pro Glu Leu Glu Thr  Arg Trp Gln Asp Leu  Lys Ile Arg 
    3770                 3775                 3780             


Ala Leu  Asp Thr Cys Lys Ala  Val Glu Ala Ala Glu  Glu Arg Leu 
    3785                 3790                 3795             


Leu Thr  Met Leu Leu Phe Gln  Asn Pro Lys Arg Gln  Lys Pro Ala 
    3800                 3805                 3810             


Lys Phe  Leu Arg Asn Ile Val  Arg Ala Gln Gly Lys  Leu Cys Gln 
    3815                 3820                 3825             


Leu Arg  Ala His Cys Glu Glu  Leu Glu Gly Gln Lys  Leu Gln Glu 
    3830                 3835                 3840             


Met Val  Leu Trp Ala Pro Tyr  Arg Pro Val Val Trp  His Gly Met 
    3845                 3850                 3855             


Ala Met  Val Lys Ala Leu Ser  Gln Leu Gln Asn Leu  Leu Pro Leu 
    3860                 3865                 3870             


Phe Cys  Met Ser Pro Glu Asn  Trp Leu Ala Val Thr  Lys Gln Ala 
    3875                 3880                 3885             


Leu Asp  Ser Met Lys Pro Arg  Glu Ile Asn His Gly  Glu Asp Leu 
    3890                 3895                 3900             


Ala Ser  His Leu Leu Gln Leu  Arg Ala His Leu Thr  Arg Gln Leu 
    3905                 3910                 3915             


Leu Gly  Ser Thr Val Thr Ala  Leu Gly Leu Thr Gln  Val Pro Leu 
    3920                 3925                 3930             


Val Gly  Ala Leu Gly Ala Leu  Ala Leu Leu Gln Ala  Thr Gly Lys 
    3935                 3940                 3945             


Ala Ser  Glu Leu Glu Arg Leu  Ala Leu Trp Pro Gly  Leu Ala Ala 
    3950                 3955                 3960             


Ser Pro  Ser Thr Val His Ser  Lys Pro Val Ser Asp  Val Ala Arg 
    3965                 3970                 3975             


Pro Ala  Trp Leu Gly Pro Lys  Ala Trp His Glu Cys  Glu Met Leu 
    3980                 3985                 3990             


Glu Leu  Leu Pro Pro Phe Val  Gly Leu Cys Ala Ser  Leu Ala Gly 
    3995                 4000                 4005             


His Ser  Ser Ala Trp Gln Ala  Tyr Leu Ser Leu Ser  Ser Thr Val 
    4010                 4015                 4020             


Leu Gly  Pro Ala Pro Gly Pro  Gly Pro Glu Pro Leu  Ser Leu Leu 
    4025                 4030                 4035             


Gln Lys  Leu Ile Leu Trp Arg  Val Leu Arg Pro Glu  Cys Leu Ala 
    4040                 4045                 4050             


Gly Ala  Leu Ala Asp Phe Thr  Thr Ser Leu Leu Gly  Arg Pro Leu 
    4055                 4060                 4065             


Asp Glu  Asn Thr Tyr Ala Pro  Thr Met Pro Phe Lys  His Ser Gln 
    4070                 4075                 4080             


Ala Thr  Gln Pro Met Leu Ile  Leu Leu Pro Pro Pro  Gly His Pro 
    4085                 4090                 4095             


Ser Ala  Thr Leu His Pro Leu  Thr Val Ile Gln Lys  Leu Ala Ala 
    4100                 4105                 4110             


Lys Tyr  Gln Gln Gly Gln Lys  Gln Leu Gln Val Ile  Ala Leu Gly 
    4115                 4120                 4125             


Ser Glu  Ala Trp Asp Pro Val  Ser Val Val Val Ser  Thr Leu Ser 
    4130                 4135                 4140             


Gln Ala  Met Tyr Glu Gly His  Trp Leu Val Leu Asp  Asn Cys His 
    4145                 4150                 4155             


Leu Met  Pro His Trp Pro Lys  Glu Leu Leu Gln Leu  Leu Leu Glu 
    4160                 4165                 4170             


Leu Leu  Gly Arg Ala Lys Val  Val Ala Asp Leu Glu  Ser Glu Gln 
    4175                 4180                 4185             


Leu Leu  Asp Gln Pro Glu Ser  Arg Asn Val Ser Thr  Val His Arg 
    4190                 4195                 4200             


Asp Phe  Arg Leu Trp Leu Ile  Val Pro Ala Glu Ser  Ser Ala Ser 
    4205                 4210                 4215             


Leu Pro  Ala Val Leu Thr Gln  His Ser Met Pro Val  Phe Trp Asn 
    4220                 4225                 4230             


Gln Ser  Leu Glu Leu Gly His  Val Leu Ile Asp Ser  Val Glu Leu 
    4235                 4240                 4245             


Ala Gln  Gln Val Leu Tyr Met  Gln Pro Pro Thr Gln  Ala Leu Pro 
    4250                 4255                 4260             


Leu Leu  Leu Leu His Gly Leu  Leu Leu His Arg Gln  Leu Tyr Gly 
    4265                 4270                 4275             


Thr Arg  Leu Gln Ala His Arg  Gly Arg Trp Ser Gln  Val Thr Leu 
    4280                 4285                 4290             


Thr Gln  Val Leu Gln Thr Gln  Asp Gln Leu Trp Ala  Ser Leu Ser 
    4295                 4300                 4305             


Asn Pro  Arg Ala Ala Met Gln  Glu Leu Ala Ala Ser  Val Phe Tyr 
    4310                 4315                 4320             


Gly Gly  Pro Leu Gly Asp Thr  Glu Asp Arg Glu Ala  Leu Ile Ser 
    4325                 4330                 4335             


Leu Thr  Gln Ala Cys Leu Ser  Pro Ser Ser Gly Ser  Trp Val Gln 
    4340                 4345                 4350             


Pro His  Thr Pro Gln Ser Leu  Leu Ala Thr Leu Met  Pro Leu Pro 
    4355                 4360                 4365             


Glu Leu  Arg Glu Leu Asp Ala  Met Ala Glu Cys Lys  Ala Gln Met 
    4370                 4375                 4380             


His Leu  Leu Pro Ser Pro Pro  Glu Pro Arg Leu Cys  Gly Leu Ser 
    4385                 4390                 4395             


Glu Gly  Pro Gln Ala Trp Leu  Leu Arg Arg Gln Ser  Arg Ala Leu 
    4400                 4405                 4410             


Leu Ser  Ala Leu Gln Arg Ser  Ser Pro Val Trp Val  Pro Glu Ser 
    4415                 4420                 4425             


Arg Arg  Gly Ala Gln Leu Ala  Glu Arg Arg Leu Arg  Gln Arg Leu 
    4430                 4435                 4440             


Val Gln  Val Asn Arg Arg Leu  Glu Ser Leu Gln Asp  Leu Leu Thr 
    4445                 4450                 4455             


His Val  Ile Arg Gln Asp Glu  Ser Asp Ala Pro Trp  Ser Val Leu 
    4460                 4465                 4470             


Gly Pro  Asn Ala Arg Arg Pro  Leu Glu Gly Val Leu  Glu Thr Glu 
    4475                 4480                 4485             


Ala Leu  Glu Leu Ser Gln Leu  Val Gly Thr Leu Gln  Arg Asp Leu 
    4490                 4495                 4500             


Asp Cys  Leu Leu Gln Gln Leu  Lys Gly Ala Pro Pro  Cys Pro Ser 
    4505                 4510                 4515             


Arg Arg  Cys Ala Ala Val Ala  His Ala Leu Trp Thr  Gly Arg Leu 
    4520                 4525                 4530             


Pro Leu  Pro Trp Arg Pro His  Ala Pro Ala Gly Pro  Gln Pro Pro 
    4535                 4540                 4545             


Trp His  Trp Leu Arg Gln Leu  Ser Arg Arg Gly Gln  Leu Leu Val 
    4550                 4555                 4560             


Arg Tyr  Leu Gly Val Gly Ala  Asp Ala Ser Ser Asp  Val Pro Glu 
    4565                 4570                 4575             


Arg Val  Phe His Leu Ser Ala  Phe Arg His Pro Arg  Arg Leu Leu 
    4580                 4585                 4590             


Leu Ala  Leu Arg Gly Glu Ala  Ala Leu Asp Gln Asn  Val Pro Ser 
    4595                 4600                 4605             


Ser Asn  Phe Pro Gly Ser Arg  Gly Ser Val Ser Ser  Gln Leu Gln 
    4610                 4615                 4620             


Tyr Lys  Arg Leu Glu Met Asn  Ser Asn Pro Leu His  Phe Arg Val 
    4625                 4630                 4635             


Glu Asn  Gly Pro Asn Pro Thr  Val Pro Glu Arg Gly  Leu Leu Leu 
    4640                 4645                 4650             


Ile Gly  Leu Gln Val Leu His  Ala Glu Trp Asp Pro  Ile Ala Gly 
    4655                 4660                 4665             


Ala Leu  Gln Asp Ser Pro Ser  Ser Gln Pro Ser Pro  Leu Pro Pro 
    4670                 4675                 4680             


Val Ser  Ile Ser Thr Gln Ala  Pro Gly Thr Ser Asp  Leu Pro Ala 
    4685                 4690                 4695             


Pro Ala  Asp Leu Thr Val Tyr  Ser Cys Pro Val Tyr  Met Gly Gly 
    4700                 4705                 4710             


Pro Leu  Gly Thr Ala Lys Leu  Gln Ser Arg Asn Ile  Val Met His 
    4715                 4720                 4725             


Leu Pro  Leu Pro Thr Lys Leu  Thr Pro Asn Thr Cys  Val Gln Arg 
    4730                 4735                 4740             


Arg Val  His Val Cys Ser Pro  Pro Leu Ser 
    4745                 4750             


<210> 4836
<211> 392
<212> PRT
<213> Homo sapiens

<400> 4836
Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro 
1               5                   10                  15      


Ala Ala Gly Lys Glu Ala Gln Lys Gly Pro Leu Leu Phe Asp Asp Leu 
            20                  25                  30          


Pro Pro Ala Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
        35                  40                  45              


Asp Asp Leu Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr 
    50                  55                  60                  


Ser Ile Ser Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Ser Glu Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys 
                85                  90                  95      


Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
            100                 105                 110         


Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
        115                 120                 125             


Asn Asp Ile Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg 
    130                 135                 140                 


Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
145                 150                 155                 160 


Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                165                 170                 175     


Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
            180                 185                 190         


Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
        195                 200                 205             


Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
    210                 215                 220                 


Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
225                 230                 235                 240 


Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                245                 250                 255     


Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
            260                 265                 270         


Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
        275                 280                 285             


Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
    290                 295                 300                 


Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
305                 310                 315                 320 


Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                325                 330                 335     


Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
            340                 345                 350         


Arg Glu Gly Lys Ser Ala Ala Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
        355                 360                 365             


Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
    370                 375                 380                 


Val Met Val Val Arg Ile Gly His 
385                 390         


<210> 4837
<211> 730
<212> PRT
<213> Homo sapiens

<400> 4837
Met Phe Gly Arg Lys Arg Ser Val Ser Phe Gly Gly Phe Gly Trp Ile 
1               5                   10                  15      


Asp Lys Thr Met Leu Ala Ser Leu Lys Val Lys Lys Gln Glu Leu Ala 
            20                  25                  30          


Asn Ser Ser Asp Ala Thr Leu Pro Asp Arg Pro Leu Ser Pro Pro Leu 
        35                  40                  45              


Thr Ala Pro Pro Thr Met Lys Ser Ser Glu Phe Phe Glu Met Leu Glu 
    50                  55                  60                  


Lys Met Gln Gly Ile Lys Leu Glu Glu Gln Lys Pro Gly Pro Gln Lys 
65                  70                  75                  80  


Asn Lys Asp Asp Tyr Ile Pro Tyr Pro Ser Ile Asp Glu Val Val Glu 
                85                  90                  95      


Lys Gly Gly Pro Tyr Pro Gln Val Ile Leu Pro Gln Phe Gly Gly Tyr 
            100                 105                 110         


Trp Ile Glu Asp Pro Glu Asn Val Gly Thr Pro Thr Ser Leu Gly Ser 
        115                 120                 125             


Ser Ile Cys Glu Glu Glu Glu Glu Asp Asn Leu Ser Pro Asn Thr Phe 
    130                 135                 140                 


Gly Tyr Lys Leu Glu Cys Lys Gly Glu Ala Arg Ala Tyr Arg Arg His 
145                 150                 155                 160 


Phe Leu Gly Lys Asp His Leu Asn Phe Tyr Cys Thr Gly Ser Ser Leu 
                165                 170                 175     


Gly Asn Leu Ile Leu Ser Val Lys Cys Glu Glu Ala Glu Gly Ile Glu 
            180                 185                 190         


Tyr Leu Arg Val Ile Leu Arg Ser Lys Leu Lys Thr Val His Glu Arg 
        195                 200                 205             


Ile Pro Leu Ala Gly Leu Ser Lys Leu Pro Ser Val Pro Gln Ile Ala 
    210                 215                 220                 


Lys Ala Phe Cys Asp Asp Ala Val Gly Leu Arg Phe Asn Pro Val Leu 
225                 230                 235                 240 


Tyr Pro Lys Ala Ser Gln Met Ile Val Ser Tyr Asp Glu His Glu Val 
                245                 250                 255     


Asn Asn Thr Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala Arg Gln Thr 
            260                 265                 270         


Leu Glu Glu Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro Ala Phe Lys 
        275                 280                 285             


Glu Phe Leu Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln Asp Phe Lys 
    290                 295                 300                 


Gly Phe Arg Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Val Glu 
305                 310                 315                 320 


Ser Val Tyr Thr Thr Phe Arg Asp Arg Glu Ile Met Phe His Val Ser 
                325                 330                 335     


Thr Lys Leu Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu Gln Arg Lys 
            340                 345                 350         


Arg His Ile Gly Asn Asp Ile Val Ala Ile Ile Phe Gln Glu Glu Asn 
        355                 360                 365             


Thr Pro Phe Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr 
    370                 375                 380                 


Ile Val Val Gln Val Glu Thr Pro Gly Thr Glu Thr Pro Ser Tyr Lys 
385                 390                 395                 400 


Val Ser Val Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro Pro Leu 
                405                 410                 415     


Pro Ser Pro Pro Val Phe Gln Lys Gly Pro Glu Phe Arg Glu Phe Leu 
            420                 425                 430         


Leu Thr Lys Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser Asp Lys 
        435                 440                 445             


Phe Ala Lys Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp Asn Leu 
    450                 455                 460                 


His Asp Glu Leu His Ala His Thr Gln Ala Met Leu Gly Leu Gly Pro 
465                 470                 475                 480 


Glu Glu Asp Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu Glu Ser 
                485                 490                 495     


Phe Lys Arg Ala Ile Arg Val Arg Ser His Ser Met Glu Thr Met Val 
            500                 505                 510         


Gly Gly Gln Lys Lys Ser His Ser Gly Gly Ile Pro Gly Ser Leu Ser 
        515                 520                 525             


Gly Gly Ile Ser His Asn Ser Met Glu Val Thr Lys Thr Thr Phe Ser 
    530                 535                 540                 


Pro Pro Val Val Ala Ala Thr Val Lys Asn Gln Ser Arg Ser Pro Ile 
545                 550                 555                 560 


Lys Arg Arg Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser Glu Gly 
                565                 570                 575     


Gln Gly Asp Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr Pro Lys 
            580                 585                 590         


Thr Pro Asp Gly Gly His Ser Ser Gln Glu Ile Lys Ser Glu Thr Ser 
        595                 600                 605             


Ser Asn Pro Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu Lys Pro Phe 
    610                 615                 620                 


Met Lys Leu Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser Ser Ser Ser 
625                 630                 635                 640 


Thr Ser Ser Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met Glu Glu 
                645                 650                 655     


Gly Asp Ser Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro Phe Lys Gln 
            660                 665                 670         


Glu Val Phe Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro Ser Leu 
        675                 680                 685             


Gly Ala Ala Ala Thr Pro Ile Ile Met Ser Arg Ser Pro Thr Asp Ala 
    690                 695                 700                 


Lys Ser Arg Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe Asp Lys 
705                 710                 715                 720 


Leu Ser His Ala Ser Ser Gly Ala Gly His 
                725                 730 


<210> 4838
<211> 369
<212> PRT
<213> Homo sapiens

<400> 4838
Met Trp Ser Gly Arg Lys Leu Gly Ser Ser Gly Gly Trp Phe Leu Arg 
1               5                   10                  15      


Val Leu Gly Pro Gly Gly Cys Asn Thr Lys Ala Ala Arg Pro Leu Ile 
            20                  25                  30          


Ser Ser Ala Val Tyr Val Lys Asn Gln Leu Ser Gly Thr Leu Gln Ile 
        35                  40                  45              


Lys Pro Gly Val Phe Asn Glu Tyr Arg Thr Ile Trp Phe Lys Ser Tyr 
    50                  55                  60                  


Arg Thr Ile Phe Ser Cys Leu Asn Arg Ile Lys Ser Phe Arg Tyr Pro 
65                  70                  75                  80  


Trp Ala Arg Leu Tyr Ser Thr Ser Gln Thr Thr Val Asp Ser Gly Glu 
                85                  90                  95      


Val Lys Thr Phe Leu Ala Leu Ala His Lys Trp Trp Asp Glu Gln Gly 
            100                 105                 110         


Val Tyr Ala Pro Leu His Ser Met Asn Asp Leu Arg Val Pro Phe Ile 
        115                 120                 125             


Arg Asp Asn Leu Leu Lys Thr Ile Pro Asn His Gln Pro Gly Lys Pro 
    130                 135                 140                 


Leu Leu Gly Met Lys Ile Leu Asp Val Gly Cys Gly Gly Gly Leu Leu 
145                 150                 155                 160 


Thr Glu Pro Leu Gly Arg Leu Gly Ala Ser Val Ile Gly Ile Asp Pro 
                165                 170                 175     


Val Asp Glu Asn Ile Lys Thr Ala Gln Cys His Lys Ser Phe Asp Pro 
            180                 185                 190         


Val Leu Asp Lys Arg Ile Glu Tyr Arg Val Cys Ser Leu Glu Glu Ile 
        195                 200                 205             


Val Glu Glu Thr Ala Glu Thr Phe Asp Ala Val Val Ala Ser Glu Val 
    210                 215                 220                 


Val Glu His Val Ile Asp Leu Glu Thr Phe Leu Gln Cys Cys Cys Gln 
225                 230                 235                 240 


Val Leu Lys Pro Gly Gly Ser Leu Phe Ile Thr Thr Ile Asn Lys Thr 
                245                 250                 255     


Gln Leu Ser Tyr Ala Leu Gly Ile Val Phe Ser Glu Gln Ile Ala Ser 
            260                 265                 270         


Ile Val Pro Lys Gly Thr His Thr Trp Glu Lys Phe Val Ser Pro Glu 
        275                 280                 285             


Thr Leu Glu Ser Ile Leu Glu Ser Asn Gly Leu Ser Val Gln Thr Val 
    290                 295                 300                 


Val Gly Met Leu Tyr Asn Pro Phe Ser Gly Tyr Trp His Trp Ser Glu 
305                 310                 315                 320 


Asn Thr Ser Leu Asn Tyr Ala Ala Tyr Ala Val Lys Ser Arg Val Gln 
                325                 330                 335     


Glu His Pro Ala Ser Ala Glu Phe Val Leu Lys Gly Glu Thr Glu Glu 
            340                 345                 350         


Leu Gln Ala Asn Ala Cys Thr Asn Pro Ala Val His Glu Lys Leu Lys 
        355                 360                 365             


Lys 
    


<210> 4839
<211> 593
<212> PRT
<213> Homo sapiens

<400> 4839
Met Glu Gly Cys Met Gly Glu Glu Ser Phe Gln Met Trp Glu Leu Asn 
1               5                   10                  15      


Arg Arg Leu Glu Ala Tyr Leu Ala Arg Val Lys Ala Leu Glu Glu Gln 
            20                  25                  30          


Asn Glu Leu Leu Ser Ala Glu Leu Gly Gly Leu Arg Ala Gln Ser Ala 
        35                  40                  45              


Asp Thr Ser Trp Arg Ala His Ala Asp Asp Glu Leu Ala Ala Leu Arg 
    50                  55                  60                  


Ala Leu Val Asp Gln Arg Trp Arg Glu Lys His Ala Ala Glu Val Ala 
65                  70                  75                  80  


Arg Asp Asn Leu Ala Glu Glu Leu Glu Gly Val Ala Gly Arg Cys Gln 
                85                  90                  95      


Gln Leu Arg Leu Ala Arg Glu Arg Thr Thr Glu Glu Val Ala Arg Asn 
            100                 105                 110         


Arg Arg Ala Val Glu Ala Glu Lys Cys Ala Arg Ala Trp Leu Ser Ser 
        115                 120                 125             


Gln Val Ala Glu Leu Glu Arg Glu Leu Glu Ala Leu Arg Val Ala His 
    130                 135                 140                 


Glu Glu Glu Arg Val Gly Leu Asn Ala Gln Ala Ala Cys Ala Pro Arg 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Arg Gly Pro Pro Ala Pro Ala Pro Glu Val Glu 
                165                 170                 175     


Glu Leu Ala Arg Arg Leu Gly Glu Ala Trp Arg Gly Ala Val Arg Gly 
            180                 185                 190         


Tyr Gln Glu Arg Val Ala His Met Glu Thr Ser Leu Gly Gln Ala Arg 
        195                 200                 205             


Glu Arg Leu Gly Arg Ala Val Gln Gly Ala Arg Glu Gly Arg Leu Glu 
    210                 215                 220                 


Leu Gln Gln Leu Gln Ala Glu Arg Gly Gly Leu Leu Glu Arg Arg Ala 
225                 230                 235                 240 


Ala Leu Glu Gln Arg Leu Glu Gly Arg Trp Gln Glu Arg Leu Arg Ala 
                245                 250                 255     


Thr Glu Lys Phe Gln Leu Ala Val Glu Ala Leu Glu Gln Glu Lys Gln 
            260                 265                 270         


Gly Leu Gln Ser Gln Ile Ala Gln Val Leu Glu Gly Arg Gln Gln Leu 
        275                 280                 285             


Ala His Leu Lys Met Ser Leu Ser Leu Glu Val Ala Thr Tyr Arg Thr 
    290                 295                 300                 


Leu Leu Glu Ala Glu Asn Ser Arg Leu Gln Thr Pro Gly Gly Gly Ser 
305                 310                 315                 320 


Lys Thr Ser Leu Ser Phe Gln Asp Pro Lys Leu Glu Leu Gln Phe Pro 
                325                 330                 335     


Arg Thr Pro Glu Gly Arg Arg Leu Gly Ser Leu Leu Pro Val Leu Ser 
            340                 345                 350         


Pro Thr Ser Leu Pro Ser Pro Leu Pro Ala Thr Leu Glu Thr Pro Val 
        355                 360                 365             


Pro Ala Phe Leu Lys Asn Gln Glu Phe Leu Gln Ala Arg Thr Pro Thr 
    370                 375                 380                 


Leu Ala Ser Thr Pro Ile Pro Pro Thr Pro Gln Ala Pro Ser Pro Ala 
385                 390                 395                 400 


Val Asp Ala Glu Ile Arg Ala Gln Asp Ala Pro Leu Ser Leu Leu Gln 
                405                 410                 415     


Thr Gln Gly Gly Arg Lys Gln Ala Pro Glu Pro Leu Arg Ala Glu Ala 
            420                 425                 430         


Arg Val Ala Ile Pro Ala Ser Val Leu Pro Gly Pro Glu Glu Pro Gly 
        435                 440                 445             


Gly Gln Arg Gln Glu Ala Ser Thr Gly Gln Ser Pro Glu Asp His Ala 
    450                 455                 460                 


Ser Leu Ala Pro Pro Leu Ser Pro Asp His Ser Ser Leu Glu Ala Lys 
465                 470                 475                 480 


Asp Gly Glu Ser Gly Gly Ser Arg Val Phe Ser Ile Cys Arg Gly Glu 
                485                 490                 495     


Gly Glu Gly Gln Ile Trp Gly Leu Val Glu Lys Glu Thr Ala Ile Glu 
            500                 505                 510         


Gly Lys Val Val Ser Ser Leu Gln Gln Glu Ile Trp Glu Glu Glu Asp 
        515                 520                 525             


Leu Asn Arg Lys Glu Ile Gln Asp Ser Gln Val Pro Leu Glu Lys Glu 
    530                 535                 540                 


Thr Leu Lys Ser Leu Gly Glu Glu Ile Gln Glu Ser Leu Lys Thr Leu 
545                 550                 555                 560 


Glu Asn Gln Ser His Glu Thr Leu Glu Arg Glu Asn Gln Glu Cys Pro 
                565                 570                 575     


Arg Ser Leu Glu Glu Asp Leu Glu Thr Leu Lys Ser Leu Glu Lys Lys 
            580                 585                 590         


Lys 
    


<210> 4840
<211> 1151
<212> PRT
<213> Homo sapiens

<400> 4840
Met Met Ala Ala Ala Leu Gly Pro Pro Glu Val Ile Ala Gln Leu Glu 
1               5                   10                  15      


Asn Ala Ala Lys Val Leu Met Ala Pro Pro Ser Met Val Asn Asn Glu 
            20                  25                  30          


Gln Arg Gln His Ala Glu His Ile Phe Leu Ser Phe Arg Lys Ser Lys 
        35                  40                  45              


Ser Pro Phe Ala Val Cys Lys His Ile Leu Glu Thr Ser Lys Val Asp 
    50                  55                  60                  


Tyr Val Leu Phe Gln Ala Ala Thr Ala Ile Met Glu Ala Val Val Arg 
65                  70                  75                  80  


Glu Trp Ile Leu Leu Glu Lys Gly Ser Ile Glu Ser Leu Arg Thr Phe 
                85                  90                  95      


Leu Leu Thr Tyr Val Leu Gln Arg Pro Asn Leu Gln Lys Tyr Val Arg 
            100                 105                 110         


Glu Gln Ile Leu Leu Ala Val Ala Val Ile Val Lys Arg Gly Ser Leu 
        115                 120                 125             


Asp Lys Ser Ile Asp Cys Lys Ser Ile Phe His Glu Val Ser Gln Leu 
    130                 135                 140                 


Ile Ser Ser Gly Asn Pro Thr Val Gln Thr Leu Ala Cys Ser Ile Leu 
145                 150                 155                 160 


Thr Ala Leu Leu Ser Glu Phe Ser Ser Ser Ser Lys Thr Ser Asn Ile 
                165                 170                 175     


Gly Leu Ser Met Glu Phe His Gly Asn Cys Lys Arg Val Phe Gln Glu 
            180                 185                 190         


Glu Asp Leu Arg Gln Ile Phe Met Leu Thr Val Glu Val Leu Gln Glu 
        195                 200                 205             


Phe Ser Arg Arg Glu Asn Leu Asn Ala Gln Met Ser Ser Val Phe Gln 
    210                 215                 220                 


Arg Tyr Leu Ala Leu Ala Asn Gln Val Leu Ser Trp Asn Phe Leu Pro 
225                 230                 235                 240 


Pro Asn Leu Gly Arg His Tyr Ile Ala Met Phe Glu Ser Ser Gln Asn 
                245                 250                 255     


Val Leu Leu Lys Pro Thr Glu Ser Trp Arg Glu Thr Leu Leu Asp Ser 
            260                 265                 270         


Arg Val Met Glu Leu Phe Phe Thr Val His Arg Lys Ile Arg Glu Asp 
        275                 280                 285             


Ser Asp Met Ala Gln Asp Ser Leu Gln Cys Leu Ala Gln Leu Ala Ser 
    290                 295                 300                 


Leu His Gly Pro Ile Phe Pro Asp Glu Gly Ser Gln Val Asp Tyr Leu 
305                 310                 315                 320 


Ala His Phe Ile Glu Gly Leu Leu Asn Thr Ile Asn Gly Ile Glu Ile 
                325                 330                 335     


Glu Asp Ser Glu Ala Val Gly Ile Ser Ser Ile Ile Ser Asn Leu Ile 
            340                 345                 350         


Thr Val Phe Pro Arg Asn Val Leu Thr Ala Ile Pro Ser Glu Leu Phe 
        355                 360                 365             


Ser Ser Phe Val Asn Cys Leu Thr His Leu Thr Cys Ser Phe Gly Arg 
    370                 375                 380                 


Ser Ala Ala Leu Glu Glu Val Leu Asp Lys Asp Asp Met Val Tyr Met 
385                 390                 395                 400 


Glu Ala Tyr Asp Lys Leu Leu Glu Ser Trp Leu Thr Leu Val Gln Asp 
                405                 410                 415     


Asp Lys His Phe His Lys Gly Phe Phe Thr Gln His Ala Val Gln Val 
            420                 425                 430         


Phe Asn Ser Tyr Ile Gln Cys His Leu Ala Ala Pro Asp Gly Thr Arg 
        435                 440                 445             


Asn Leu Thr Ala Asn Gly Val Ala Ser Arg Glu Glu Glu Glu Ile Ser 
    450                 455                 460                 


Glu Leu Gln Glu Asp Asp Arg Asp Gln Phe Ser Asp Gln Leu Ala Ser 
465                 470                 475                 480 


Val Gly Met Leu Gly Arg Ile Ala Ala Glu His Cys Ile Pro Leu Leu 
                485                 490                 495     


Thr Ser Leu Leu Glu Glu Arg Val Thr Arg Leu His Gly Gln Leu Gln 
            500                 505                 510         


Arg His Gln Gln Gln Leu Leu Ala Ser Pro Gly Ser Ser Thr Val Asp 
        515                 520                 525             


Asn Lys Met Leu Asp Asp Leu Tyr Glu Asp Ile His Trp Leu Ile Leu 
    530                 535                 540                 


Val Thr Gly Tyr Leu Leu Ala Asp Asp Thr Gln Gly Glu Thr Pro Leu 
545                 550                 555                 560 


Ile Pro Pro Glu Ile Met Glu Tyr Ser Ile Lys His Ser Ser Glu Val 
                565                 570                 575     


Asp Ile Asn Thr Thr Leu Gln Ile Leu Gly Ser Pro Gly Glu Lys Ala 
            580                 585                 590         


Ser Ser Ile Pro Gly Tyr Asn Arg Thr Asp Ser Val Ile Arg Leu Leu 
        595                 600                 605             


Ser Ala Ile Leu Arg Val Ser Glu Val Glu Ser Arg Ala Ile Arg Ala 
    610                 615                 620                 


Asp Leu Thr His Leu Leu Ser Pro Gln Met Gly Lys Asp Ile Val Trp 
625                 630                 635                 640 


Phe Leu Lys Arg Trp Ala Lys Thr Tyr Leu Leu Val Asp Glu Lys Leu 
                645                 650                 655     


Tyr Asp Gln Ile Ser Leu Pro Phe Ser Thr Ala Phe Gly Ala Asp Thr 
            660                 665                 670         


Glu Gly Ser Gln Trp Ile Ile Gly Tyr Leu Leu Gln Lys Val Ile Ser 
        675                 680                 685             


Asn Leu Ser Val Trp Ser Ser Glu Gln Asp Leu Ala Asn Asp Thr Val 
    690                 695                 700                 


Gln Leu Leu Val Thr Leu Val Glu Arg Arg Glu Arg Ala Asn Leu Val 
705                 710                 715                 720 


Ile Gln Cys Glu Asn Trp Trp Asn Leu Ala Lys Gln Phe Ala Ser Arg 
                725                 730                 735     


Ser Pro Pro Leu Asn Phe Leu Ser Ser Pro Val Gln Arg Thr Leu Met 
            740                 745                 750         


Lys Ala Leu Val Leu Gly Gly Phe Ala His Met Asp Thr Glu Thr Lys 
        755                 760                 765             


Gln Gln Tyr Trp Thr Glu Val Leu Gln Pro Leu Gln Gln Arg Phe Leu 
    770                 775                 780                 


Arg Val Ile Asn Gln Glu Asn Phe Gln Gln Met Cys Gln Gln Glu Glu 
785                 790                 795                 800 


Val Lys Gln Glu Ile Thr Ala Thr Leu Glu Ala Leu Cys Gly Ile Ala 
                805                 810                 815     


Glu Ala Thr Gln Ile Asp Asn Val Ala Ile Leu Phe Asn Phe Leu Met 
            820                 825                 830         


Asp Phe Leu Thr Asn Cys Ile Gly Leu Met Glu Val Tyr Lys Asn Thr 
        835                 840                 845             


Pro Glu Thr Val Asn Leu Ile Ile Glu Val Phe Val Glu Val Ala His 
    850                 855                 860                 


Lys Gln Ile Cys Tyr Leu Gly Glu Ser Lys Ala Met Asn Leu Tyr Glu 
865                 870                 875                 880 


Ala Cys Leu Thr Leu Leu Gln Val Tyr Ser Lys Asn Asn Leu Gly Arg 
                885                 890                 895     


Gln Arg Ile Asp Val Thr Ala Glu Glu Glu Gln Tyr Gln Asp Leu Leu 
            900                 905                 910         


Leu Ile Met Glu Leu Leu Thr Asn Leu Leu Ser Lys Glu Phe Ile Asp 
        915                 920                 925             


Phe Ser Asp Thr Asp Glu Val Phe Arg Gly His Glu Pro Gly Gln Ala 
    930                 935                 940                 


Ala Asn Arg Ser Val Ser Ala Ala Asp Val Val Leu Tyr Gly Val Asn 
945                 950                 955                 960 


Leu Ile Leu Pro Leu Met Ser Gln Asp Leu Leu Lys Phe Pro Thr Leu 
                965                 970                 975     


Cys Asn Gln Tyr Tyr Lys Leu Ile Thr Phe Ile Cys Glu Ile Phe Pro 
            980                 985                 990         


Glu Lys Ile Pro Gln Leu Pro Glu  Asp Leu Phe Lys Ser  Leu Met Tyr 
        995                 1000                 1005             


Ser Leu  Glu Leu Gly Met Thr  Ser Met Ser Ser Glu  Val Cys Gln 
    1010                 1015                 1020             


Leu Cys  Leu Glu Ala Leu Thr  Pro Leu Ala Glu Gln  Cys Ala Lys 
    1025                 1030                 1035             


Ala Gln  Glu Thr Asp Ser Pro  Leu Phe Leu Ala Thr  Arg His Phe 
    1040                 1045                 1050             


Leu Lys  Leu Val Phe Asp Met  Leu Val Leu Gln Lys  His Asn Thr 
    1055                 1060                 1065             


Glu Met  Thr Thr Ala Ala Gly  Glu Ala Phe Tyr Thr  Leu Val Cys 
    1070                 1075                 1080             


Leu His  Gln Ala Glu Tyr Ser  Glu Leu Val Glu Thr  Leu Leu Ser 
    1085                 1090                 1095             


Ser Gln  Gln Asp Pro Val Ile  Tyr Gln Arg Leu Ala  Asp Ala Phe 
    1100                 1105                 1110             


Asn Lys  Leu Thr Ala Ser Ser  Thr Pro Pro Thr Leu  Asp Arg Lys 
    1115                 1120                 1125             


Gln Lys  Met Ala Phe Leu Lys  Ser Leu Glu Glu Phe  Met Ala Asn 
    1130                 1135                 1140             


Val Gly  Gly Leu Leu Cys Val  Lys 
    1145                 1150     


<210> 4841
<211> 525
<212> PRT
<213> Homo sapiens

<400> 4841
Met Ala Ala Gly Gly Ser Gly Gly Arg Ala Ser Cys Pro Pro Gly Val 
1               5                   10                  15      


Gly Val Gly Pro Gly Thr Gly Gly Ser Pro Gly Pro Ser Ala Asn Ala 
            20                  25                  30          


Ala Ala Thr Pro Ala Pro Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Ala Pro Gly Pro Thr Pro Pro Ala Pro Pro Gly 
    50                  55                  60                  


Pro Gly Thr Asp Ala Gln Ala Ala Gly Ala Glu Arg Ala Glu Glu Ala 
65                  70                  75                  80  


Ala Gly Pro Gly Ala Ala Ala Leu Gln Arg Glu Ala Ala Tyr Asn Trp 
                85                  90                  95      


Gln Ala Ser Lys Pro Thr Val Gln Glu Arg Phe Ala Phe Leu Phe Asn 
            100                 105                 110         


Asn Glu Val Leu Cys Asp Val His Phe Leu Val Gly Lys Gly Leu Ser 
        115                 120                 125             


Ser Gln Arg Ile Pro Ala His Arg Phe Val Leu Ala Val Gly Ser Ala 
    130                 135                 140                 


Val Phe Asp Ala Met Phe Asn Gly Gly Met Ala Thr Thr Ser Thr Glu 
145                 150                 155                 160 


Ile Glu Leu Pro Asp Val Glu Pro Ala Ala Phe Leu Ala Leu Leu Lys 
                165                 170                 175     


Phe Leu Tyr Ser Asp Glu Val Gln Ile Gly Pro Glu Thr Val Met Thr 
            180                 185                 190         


Thr Leu Tyr Thr Ala Lys Lys Tyr Ala Val Pro Ala Leu Glu Ala His 
        195                 200                 205             


Cys Val Glu Phe Leu Lys Lys Asn Leu Arg Ala Asp Asn Ala Phe Met 
    210                 215                 220                 


Leu Leu Thr Gln Ala Arg Leu Phe Asp Glu Pro Gln Leu Ala Ser Leu 
225                 230                 235                 240 


Cys Leu Glu Asn Ile Asp Lys Asn Thr Ala Asp Ala Ile Thr Ala Glu 
                245                 250                 255     


Gly Phe Thr Asp Ile Asp Leu Asp Thr Leu Val Ala Val Leu Glu Arg 
            260                 265                 270         


Asp Thr Leu Gly Ile Arg Glu Val Arg Leu Phe Asn Ala Val Val Arg 
        275                 280                 285             


Trp Ser Glu Ala Glu Cys Gln Arg Gln Gln Leu Gln Val Thr Pro Glu 
    290                 295                 300                 


Asn Arg Arg Lys Val Leu Gly Lys Ala Leu Gly Leu Ile Arg Phe Pro 
305                 310                 315                 320 


Leu Met Thr Ile Glu Glu Phe Ala Ala Gly Pro Ala Gln Ser Gly Ile 
                325                 330                 335     


Leu Val Asp Arg Glu Val Val Ser Leu Phe Leu His Phe Thr Val Asn 
            340                 345                 350         


Pro Lys Pro Arg Val Glu Phe Ile Asp Arg Pro Arg Cys Cys Leu Arg 
        355                 360                 365             


Gly Lys Glu Cys Ser Ile Asn Arg Phe Gln Gln Val Glu Ser Arg Trp 
    370                 375                 380                 


Gly Tyr Ser Gly Thr Ser Asp Arg Ile Arg Phe Ser Val Asn Lys Arg 
385                 390                 395                 400 


Ile Phe Val Val Gly Phe Gly Leu Tyr Gly Ser Ile His Gly Pro Thr 
                405                 410                 415     


Asp Tyr Gln Val Asn Ile Gln Ile Ile His Thr Asp Ser Asn Thr Val 
            420                 425                 430         


Leu Gly Gln Asn Asp Thr Gly Phe Ser Cys Asp Gly Ser Ala Ser Thr 
        435                 440                 445             


Phe Arg Val Met Phe Lys Glu Pro Val Glu Val Leu Pro Asn Val Asn 
    450                 455                 460                 


Tyr Thr Ala Cys Ala Thr Leu Lys Gly Pro Asp Ser His Tyr Gly Thr 
465                 470                 475                 480 


Lys Gly Leu Arg Lys Val Thr His Glu Ser Pro Thr Thr Gly Ala Lys 
                485                 490                 495     


Thr Cys Phe Thr Phe Cys Tyr Ala Ala Gly Asn Asn Asn Gly Thr Ser 
            500                 505                 510         


Val Glu Asp Gly Gln Ile Pro Glu Val Ile Phe Tyr Thr 
        515                 520                 525 


<210> 4842
<211> 174
<212> PRT
<213> Homo sapiens

<400> 4842
Met Ala Thr Val Ala Glu Leu Lys Ala Val Leu Lys Asp Thr Leu Glu 
1               5                   10                  15      


Lys Lys Gly Val Leu Gly His Leu Lys Ala Arg Ile Arg Ala Glu Val 
            20                  25                  30          


Phe Asn Ala Leu Asp Asp Asp Arg Glu Pro Arg Pro Ser Leu Ser His 
        35                  40                  45              


Glu Asn Leu Leu Ile Asn Glu Leu Ile Arg Glu Tyr Leu Glu Phe Asn 
    50                  55                  60                  


Lys Tyr Lys Tyr Thr Ala Ser Val Leu Ile Ala Glu Ser Gly Gln Pro 
65                  70                  75                  80  


Val Val Pro Leu Asp Arg Gln Phe Leu Ile His Glu Leu Asn Ala Phe 
                85                  90                  95      


Glu Glu Ser Lys Asp Asn Thr Ile Pro Leu Leu Tyr Gly Ile Leu Ala 
            100                 105                 110         


His Phe Leu Arg Gly Thr Lys Asp Gly Ile Gln Asn Ala Phe Leu Lys 
        115                 120                 125             


Gly Pro Ser Leu Gln Pro Ser Asp Pro Ser Leu Gly Arg Gln Pro Ser 
    130                 135                 140                 


Arg Arg Lys Pro Met Asp Asp His Leu Arg Lys Glu Glu Gln Lys Ser 
145                 150                 155                 160 


Thr Asn Ile Glu Asp Leu His Val Ser Gln Ala Val Asn Arg 
                165                 170                 


<210> 4843
<211> 418
<212> PRT
<213> Homo sapiens

<400> 4843
Met Ala Gly Ser Leu Pro Pro Cys Val Val Asp Cys Gly Thr Gly Tyr 
1               5                   10                  15      


Thr Lys Leu Gly Tyr Ala Gly Asn Thr Glu Pro Gln Phe Ile Ile Pro 
            20                  25                  30          


Ser Cys Ile Ala Ile Arg Glu Ser Ala Lys Val Val Asp Gln Ala Gln 
        35                  40                  45              


Arg Arg Val Leu Arg Gly Val Asp Asp Leu Asp Phe Phe Ile Gly Asp 
    50                  55                  60                  


Glu Ala Ile Asp Lys Pro Thr Tyr Ala Thr Lys Trp Pro Ile Arg His 
65                  70                  75                  80  


Gly Ile Ile Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gln Val 
                85                  90                  95      


Val Phe Lys Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Met 
            100                 105                 110         


Thr Glu Pro Pro Leu Asn Thr Pro Glu Asn Arg Glu Tyr Leu Ala Glu 
        115                 120                 125             


Ile Met Phe Glu Ser Phe Asn Val Pro Gly Leu Tyr Ile Ala Val Gln 
    130                 135                 140                 


Ala Val Leu Ala Leu Ala Ala Ser Trp Thr Ser Arg Gln Val Gly Glu 
145                 150                 155                 160 


Arg Thr Leu Thr Gly Ile Val Ile Asp Ser Gly Asp Gly Val Thr His 
                165                 170                 175     


Val Ile Pro Val Ala Glu Gly Tyr Val Ile Gly Ser Cys Ile Lys His 
            180                 185                 190         


Ile Pro Ile Ala Gly Arg Asp Ile Thr Tyr Phe Ile Gln Gln Leu Leu 
        195                 200                 205             


Arg Glu Arg Glu Val Gly Ile Pro Pro Glu Gln Ser Leu Glu Thr Ala 
    210                 215                 220                 


Lys Ala Ile Lys Glu Lys Tyr Cys Tyr Ile Cys Pro Asp Ile Val Lys 
225                 230                 235                 240 


Glu Phe Ala Lys Tyr Asp Val Asp Pro Arg Lys Trp Ile Lys Gln Tyr 
                245                 250                 255     


Thr Gly Ile Asn Ala Ile Asn Gln Lys Lys Phe Val Ile Asp Val Gly 
            260                 265                 270         


Tyr Glu Arg Phe Leu Gly Pro Glu Ile Phe Phe His Pro Glu Phe Ala 
        275                 280                 285             


Asn Pro Asp Phe Met Glu Ser Ile Ser Asp Val Val Asp Glu Val Ile 
    290                 295                 300                 


Gln Asn Cys Pro Ile Asp Val Arg Arg Pro Leu Tyr Lys Asn Val Val 
305                 310                 315                 320 


Leu Ser Gly Gly Ser Thr Met Phe Arg Asp Phe Gly Arg Arg Leu Gln 
                325                 330                 335     


Arg Asp Leu Lys Arg Val Val Asp Ala Arg Leu Arg Leu Ser Glu Glu 
            340                 345                 350         


Leu Ser Gly Gly Arg Ile Lys Pro Lys Pro Val Glu Val Gln Val Val 
        355                 360                 365             


Thr His His Met Gln Arg Tyr Ala Val Trp Phe Gly Gly Ser Met Leu 
    370                 375                 380                 


Ala Ser Thr Pro Glu Phe Phe Gln Val Cys His Thr Lys Lys Asp Tyr 
385                 390                 395                 400 


Glu Glu Tyr Gly Pro Ser Ile Cys Arg His Asn Pro Val Phe Gly Val 
                405                 410                 415     


Met Ser 
        


<210> 4844
<211> 347
<212> PRT
<213> Homo sapiens

<400> 4844
Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Thr Phe Ser Tyr Val Thr His 
                165                 170                 175     


Glu Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln 
            180                 185                 190         


Ala Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln 
        195                 200                 205             


Asn Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro 
    210                 215                 220                 


Ile His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val 
225                 230                 235                 240 


Val Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln 
                245                 250                 255     


Ser Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn 
            260                 265                 270         


Leu Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr 
        275                 280                 285             


Ser Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile 
    290                 295                 300                 


Asp Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro 
305                 310                 315                 320 


Thr Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val 
                325                 330                 335     


Cys Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345         


<210> 4845
<211> 211
<212> PRT
<213> Homo sapiens

<400> 4845
Met Cys Pro Gly Asn Trp Leu Trp Ala Ser Met Thr Phe Met Ala Arg 
1               5                   10                  15      


Phe Ser Arg Ser Ser Ser Arg Ser Pro Val Arg Thr Arg Gly Thr Leu 
            20                  25                  30          


Glu Glu Met Pro Thr Val Gln His Pro Phe Leu Asn Val Phe Glu Leu 
        35                  40                  45              


Glu Arg Leu Leu Tyr Thr Gly Lys Thr Ala Cys Asn His Ala Asp Glu 
    50                  55                  60                  


Val Trp Pro Gly Leu Tyr Leu Gly Asp Gln Asp Met Ala Asn Asn Arg 
65                  70                  75                  80  


Arg Glu Leu Arg Arg Leu Gly Ile Thr His Val Leu Asn Ala Ser His 
                85                  90                  95      


Ser Arg Trp Arg Gly Thr Pro Glu Ala Tyr Glu Gly Leu Gly Ile Arg 
            100                 105                 110         


Tyr Leu Gly Val Glu Ala His Asp Ser Pro Ala Phe Asp Met Ser Ile 
        115                 120                 125             


His Phe Gln Thr Ala Ala Asp Phe Ile His Arg Ala Leu Ser Gln Pro 
    130                 135                 140                 


Gly Gly Lys Ile Leu Val His Cys Ala Val Gly Val Ser Arg Ser Ala 
145                 150                 155                 160 


Thr Leu Val Leu Ala Tyr Leu Met Leu Tyr His His Leu Thr Leu Val 
                165                 170                 175     


Glu Ala Ile Lys Lys Val Lys Asp His Arg Gly Ile Ile Pro Asn Arg 
            180                 185                 190         


Gly Phe Leu Arg Gln Leu Leu Ala Leu Asp Arg Arg Leu Arg Gln Gly 
        195                 200                 205             


Leu Glu Ala 
    210     


<210> 4846
<211> 315
<212> PRT
<213> Homo sapiens

<400> 4846
Met Pro Gly Leu Ser Cys Arg Phe Tyr Gln His Lys Phe Pro Glu Val 
1               5                   10                  15      


Glu Asp Val Val Met Val Asn Val Arg Ser Ile Ala Glu Met Gly Ala 
            20                  25                  30          


Tyr Val Ser Leu Leu Glu Tyr Asn Asn Ile Glu Gly Met Ile Leu Leu 
        35                  40                  45              


Ser Glu Leu Ser Arg Arg Arg Ile Arg Ser Ile Asn Lys Leu Ile Arg 
    50                  55                  60                  


Ile Gly Arg Asn Glu Cys Val Val Val Ile Arg Val Asp Lys Glu Lys 
65                  70                  75                  80  


Gly Tyr Ile Asp Leu Ser Lys Arg Arg Val Ser Pro Glu Glu Ala Ile 
                85                  90                  95      


Lys Cys Glu Asp Lys Phe Thr Lys Ser Lys Thr Val Tyr Ser Ile Leu 
            100                 105                 110         


Arg His Val Ala Glu Val Leu Glu Tyr Thr Lys Asp Glu Gln Leu Glu 
        115                 120                 125             


Ser Leu Phe Gln Arg Thr Ala Trp Val Phe Asp Asp Lys Tyr Lys Arg 
    130                 135                 140                 


Pro Gly Tyr Gly Ala Tyr Asp Ala Phe Lys His Ala Val Ser Asp Pro 
145                 150                 155                 160 


Ser Ile Leu Asp Ser Leu Asp Leu Asn Glu Asp Glu Arg Glu Val Leu 
                165                 170                 175     


Ile Asn Asn Ile Asn Arg Arg Leu Thr Pro Gln Ala Val Lys Ile Arg 
            180                 185                 190         


Ala Asp Ile Glu Val Ala Cys Tyr Gly Tyr Glu Gly Ile Asp Ala Val 
        195                 200                 205             


Lys Glu Ala Leu Arg Ala Gly Leu Asn Cys Ser Thr Glu Asn Met Pro 
    210                 215                 220                 


Ile Lys Ile Asn Leu Ile Ala Pro Pro Arg Tyr Val Met Thr Thr Thr 
225                 230                 235                 240 


Thr Leu Glu Arg Thr Glu Gly Leu Ser Val Leu Ser Gln Ala Met Ala 
                245                 250                 255     


Val Ile Lys Glu Lys Ile Glu Glu Lys Arg Gly Val Phe Asn Val Gln 
            260                 265                 270         


Met Glu Pro Lys Val Val Thr Asp Thr Asp Glu Thr Glu Leu Ala Arg 
        275                 280                 285             


Gln Met Glu Arg Leu Glu Arg Glu Asn Ala Glu Val Asp Gly Asp Asp 
    290                 295                 300                 


Asp Ala Glu Glu Met Glu Ala Lys Ala Glu Asp 
305                 310                 315 


<210> 4847
<211> 105
<212> PRT
<213> Homo sapiens

<400> 4847
Met Ala Gly Gln Glu Asp Pro Val Gln Arg Glu Ile His Gln Asp Trp 
1               5                   10                  15      


Ala Asn Arg Glu Tyr Ile Glu Ile Ile Thr Ser Ser Ile Lys Lys Ile 
            20                  25                  30          


Ala Asp Phe Leu Asn Ser Phe Asp Met Ser Cys Arg Ser Arg Leu Ala 
        35                  40                  45              


Thr Leu Asn Glu Lys Leu Thr Ala Leu Glu Arg Arg Ile Glu Tyr Ile 
    50                  55                  60                  


Glu Ala Arg Val Thr Lys Gly Glu Thr Leu Arg Thr Val Pro Cys Cys 
65                  70                  75                  80  


Cys Trp Glu Val Ala Leu His Asn Thr Gly His Met Gly Lys Ala Pro 
                85                  90                  95      


Ala Ala Phe Ser Ser Phe Leu Ser Pro 
            100                 105 


<210> 4848
<211> 633
<212> PRT
<213> Homo sapiens

<400> 4848
Met Ala Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Cys Ser Ser Gly 
1               5                   10                  15      


Ser Ala Gly Thr Asp Ala Ala Gly Ala Ser Gly Leu Gln Gln Pro Pro 
            20                  25                  30          


Pro Gln Pro Gln Pro Gln Pro Ala Ala Ala Ala Pro Ala Gln Pro Pro 
        35                  40                  45              


Pro Glu Pro Pro Arg Lys Pro Arg Met Asp Pro Arg Arg Arg Gln Ala 
    50                  55                  60                  


Ala Leu Ser Phe Leu Thr Asn Ile Ser Leu Asp Gly Arg Leu Pro Pro 
65                  70                  75                  80  


Gln Asp Ala Glu Trp Gly Gly Gly Glu Glu Gly Gly Ala Ala Lys Pro 
                85                  90                  95      


Gly Ala Gly Gly Ala Cys Gly Ala Arg Thr Arg Phe Ser Leu Leu Ala 
            100                 105                 110         


Ala Ala Glu Arg Gly Gly Cys Ile Ala Leu Ala Ala Pro Gly Thr Pro 
        115                 120                 125             


Ala Ala Gly Leu Ala Ala Gly Ser Gly Pro Cys Leu Pro Gln Pro Ser 
    130                 135                 140                 


Ser Leu Pro Pro Leu Ile Pro Gly Gly His Ala Thr Val Ser Gly Pro 
145                 150                 155                 160 


Gly Val Ala Arg Gly Phe Ala Ser Pro Leu Gly Ala Gly Arg Ala Ser 
                165                 170                 175     


Gly Glu Gln Trp Gln Pro Pro Arg Pro Ala Pro Leu Ala Ala Cys Ala 
            180                 185                 190         


Gln Leu Gln Leu Leu Asp Gly Ser Gly Ala Ala Gly Gln Glu Glu Leu 
        195                 200                 205             


Glu Glu Asp Asp Ala Phe Ile Ser Val Gln Val Pro Ala Ala Ala Phe 
    210                 215                 220                 


Leu Gly Ser Gly Thr Pro Gly Ser Gly Ser Gly Ser Arg Gly Arg Leu 
225                 230                 235                 240 


Asn Ser Phe Thr Gln Gly Ile Leu Pro Ile Ala Phe Ser Arg Pro Thr 
                245                 250                 255     


Ser Gln Asn Tyr Cys Ser Leu Glu Gln Pro Gly Gln Gly Gly Ser Thr 
            260                 265                 270         


Ser Ala Phe Glu Gln Leu Gln Arg Ser Arg Arg Arg Leu Ile Ser Gln 
        275                 280                 285             


Arg Ser Ser Leu Glu Thr Leu Glu Asp Ile Glu Glu Asn Ala Pro Leu 
    290                 295                 300                 


Arg Arg Cys Arg Thr Leu Ser Gly Ser Pro Arg Pro Lys Asn Phe Lys 
305                 310                 315                 320 


Lys Ile His Phe Ile Lys Asn Met Arg Gln His Asp Thr Arg Asn Gly 
                325                 330                 335     


Arg Ile Val Leu Ile Ser Gly Arg Arg Ser Phe Cys Ser Ile Phe Ser 
            340                 345                 350         


Val Leu Pro Tyr Arg Asp Ser Thr Gln Val Gly Asp Leu Lys Leu Asp 
        355                 360                 365             


Gly Gly Arg Gln Ser Thr Gly Ala Val Ser Leu Lys Glu Ile Ile Gly 
    370                 375                 380                 


Leu Glu Gly Val Glu Leu Gly Ala Asp Gly Lys Thr Val Ser Tyr Thr 
385                 390                 395                 400 


Gln Phe Leu Leu Pro Thr Asn Ala Phe Gly Ala Arg Arg Asn Thr Ile 
                405                 410                 415     


Asp Ser Thr Ser Ser Phe Ser Gln Phe Arg Asn Leu Ser His Arg Ser 
            420                 425                 430         


Leu Ser Ile Gly Arg Ala Ser Gly Thr Gln Gly Ser Leu Asp Thr Gly 
        435                 440                 445             


Ser Asp Leu Gly Asp Phe Met Asp Tyr Asp Pro Asn Leu Leu Asp Asp 
    450                 455                 460                 


Pro Gln Trp Pro Cys Gly Lys His Lys Arg Val Leu Ile Phe Pro Ser 
465                 470                 475                 480 


Tyr Met Thr Thr Val Ile Asp Tyr Val Lys Pro Ser Asp Leu Lys Lys 
                485                 490                 495     


Asp Met Asn Glu Thr Phe Lys Glu Lys Phe Pro His Ile Lys Leu Thr 
            500                 505                 510         


Leu Ser Lys Ile Arg Ser Leu Lys Arg Glu Met Arg Lys Leu Ala Gln 
        515                 520                 525             


Glu Asp Cys Gly Leu Glu Glu Pro Thr Val Ala Met Ala Phe Val Tyr 
    530                 535                 540                 


Phe Glu Lys Leu Ala Leu Lys Gly Lys Leu Asn Lys Gln Asn Arg Lys 
545                 550                 555                 560 


Leu Cys Ala Gly Ala Cys Val Leu Leu Ala Ala Lys Ile Gly Ser Asp 
                565                 570                 575     


Leu Lys Lys His Glu Val Lys His Leu Ile Asp Lys Leu Glu Glu Lys 
            580                 585                 590         


Phe Arg Leu Asn Arg Arg Glu Leu Ile Ala Phe Glu Phe Pro Val Leu 
        595                 600                 605             


Val Ala Leu Glu Phe Ala Leu His Leu Pro Glu His Glu Val Met Pro 
    610                 615                 620                 


His Tyr Arg Arg Leu Val Gln Ser Ser 
625                 630             


<210> 4849
<211> 1140
<212> PRT
<213> Homo sapiens

<400> 4849
Met Thr Thr Ala Val Glu Arg Lys Tyr Ile Asn Ile Arg Lys Arg Leu 
1               5                   10                  15      


Asp Gln Leu Gly Tyr Arg Gln Thr Leu Thr Val Glu Cys Leu Pro Leu 
            20                  25                  30          


Val Glu Lys Leu Phe Ser Asp Leu Val His Thr Thr Glu Ser Leu Arg 
        35                  40                  45              


Gln Ser Lys Leu Ser Ala Val Lys Ala Glu Lys Glu Ser Ala Asn Phe 
    50                  55                  60                  


Asp Phe Val Leu Glu Pro Tyr Lys Leu Glu Asn Ala Arg Leu Ser Arg 
65                  70                  75                  80  


Glu Asn Asn Glu Leu Tyr Leu Glu Leu Met Lys Leu Arg Glu His Ser 
                85                  90                  95      


Asp Gln His Val Lys Glu Leu Lys Thr Ser Leu Lys Lys Cys Ala Arg 
            100                 105                 110         


Glu Thr Ala Asp Leu Lys Phe Leu Asn Asn Gln Tyr Ala His Lys Leu 
        115                 120                 125             


Lys Leu Leu Glu Lys Glu Ser Lys Ala Lys Asn Glu Arg Ile Gln Gln 
    130                 135                 140                 


Leu Gln Glu Lys Asn Leu His Ala Val Val Gln Thr Pro Gly Gly Lys 
145                 150                 155                 160 


Lys Arg Ser Ile Ala Phe Arg Arg Gln Arg Met Gln Ile Asp Glu Pro 
                165                 170                 175     


Val Pro Pro Ser Glu Val Ser Ser Tyr Pro Val Pro Gln Pro Asp Asp 
            180                 185                 190         


Pro Tyr Ile Ala Asp Leu Leu Gln Val Ala Asp Asn Arg Ile Gln Glu 
        195                 200                 205             


Leu Gln Gln Glu Val His Gln Leu Gln Glu Lys Leu Ala Met Met Glu 
    210                 215                 220                 


Ser Gly Val Arg Asp Tyr Ser Lys Gln Ile Glu Leu Arg Glu Arg Glu 
225                 230                 235                 240 


Ile Glu Arg Leu Ser Val Ala Leu Asp Gly Gly Arg Ser Pro Asp Val 
                245                 250                 255     


Leu Ser Leu Glu Ser Arg Asn Lys Thr Asn Glu Lys Leu Ile Ala His 
            260                 265                 270         


Leu Asn Ile Gln Val Asp Phe Leu Gln Gln Ala Asn Lys Asp Leu Glu 
        275                 280                 285             


Lys Arg Ile Arg Glu Leu Met Glu Thr Lys Glu Thr Val Thr Ser Glu 
    290                 295                 300                 


Val Val Asn Leu Ser Asn Lys Asn Glu Lys Leu Cys Gln Glu Leu Thr 
305                 310                 315                 320 


Glu Ile Asp Gln Leu Ala Gln Gln Leu Glu Arg His Lys Glu Glu Val 
                325                 330                 335     


Leu Glu Thr Ala Asp Lys Glu Leu Gly Glu Ala Lys Lys Glu Ile Lys 
            340                 345                 350         


Arg Lys Leu Ser Glu Met Gln Asp Leu Glu Glu Thr Met Ala Lys Leu 
        355                 360                 365             


Gln Leu Glu Leu Asn Leu Cys Gln Lys Glu Lys Glu Arg Leu Ser Asp 
    370                 375                 380                 


Glu Leu Leu Val Lys Ser Asp Leu Glu Thr Val Val His Gln Leu Glu 
385                 390                 395                 400 


Gln Glu Lys Gln Arg Leu Ser Lys Lys Val Glu Ser Phe Ala Val Thr 
                405                 410                 415     


Glu Arg Gln Leu Thr Leu Glu Val Glu Arg Met Arg Leu Glu His Gly 
            420                 425                 430         


Ile Lys Arg Arg Asp Arg Ser Pro Ser Arg Leu Asp Thr Phe Leu Lys 
        435                 440                 445             


Gly Ile Glu Glu Glu Arg Asp Tyr Tyr Lys Lys Glu Leu Glu Arg Leu 
    450                 455                 460                 


Gln His Ile Ile Gln Arg Arg Ser Cys Ser Thr Ser Tyr Ser Ala Arg 
465                 470                 475                 480 


Glu Lys Ser Ser Ile Phe Arg Thr Pro Glu Lys Gly Asp Tyr Asn Ser 
                485                 490                 495     


Glu Ile His Gln Ile Thr Arg Glu Arg Asp Glu Leu Gln Arg Met Leu 
            500                 505                 510         


Glu Arg Phe Glu Lys Tyr Met Glu Asp Ile Gln Ser Asn Val Lys Leu 
        515                 520                 525             


Leu Thr Ala Glu Arg Asp Lys Leu Ser Val Leu Tyr Asn Glu Ala Gln 
    530                 535                 540                 


Glu Glu Leu Ser Ala Leu Arg Lys Glu Ser Thr Gln Thr Thr Ala Pro 
545                 550                 555                 560 


His Asn Ile Val Ser Leu Met Glu Lys Glu Lys Glu Leu Ala Leu Ser 
                565                 570                 575     


Asp Leu Arg Arg Ile Met Ala Glu Lys Glu Ala Leu Arg Glu Lys Leu 
            580                 585                 590         


Glu His Ile Glu Glu Val Ser Leu Phe Gly Lys Ser Glu Leu Glu Lys 
        595                 600                 605             


Thr Ile Glu His Leu Thr Cys Val Asn His Gln Leu Glu Ser Glu Lys 
    610                 615                 620                 


Tyr Glu Leu Lys Ser Lys Val Leu Ile Met Lys Glu Thr Ile Glu Ser 
625                 630                 635                 640 


Leu Glu Asn Lys Leu Lys Val Gln Ala Gln Lys Phe Ser His Val Ala 
                645                 650                 655     


Gly Asp Ser Ser His Gln Lys Thr Glu Val Asn Ser Leu Arg Ile Val 
            660                 665                 670         


Asn Glu Gln Leu Gln Arg Ser Val Asp Asp Tyr Gln His Arg Leu Ser 
        675                 680                 685             


Ile Lys Arg Gly Glu Leu Glu Ser Ala Gln Ala Gln Ile Lys Ile Leu 
    690                 695                 700                 


Glu Glu Lys Ile Asp Glu Leu Asn Leu Lys Met Thr Ser Gln Asp Glu 
705                 710                 715                 720 


Glu Ala His Val Met Lys Lys Thr Ile Gly Val Ile Asp Lys Glu Lys 
                725                 730                 735     


Asp Phe Leu Gln Glu Thr Val Asp Glu Lys Thr Glu Lys Ile Ala Asn 
            740                 745                 750         


Leu Gln Glu Asn Leu Ala Asn Lys Glu Lys Ala Val Ala Gln Met Lys 
        755                 760                 765             


Ile Met Ile Ser Glu Cys Glu Ser Ser Val Asn Gln Leu Lys Glu Thr 
    770                 775                 780                 


Leu Val Asn Arg Asp Arg Glu Ile Asn Ser Leu Arg Arg Gln Leu Asp 
785                 790                 795                 800 


Ala Ala His Lys Glu Leu Asp Glu Val Gly Arg Ser Arg Glu Ile Ala 
                805                 810                 815     


Phe Lys Glu Asn Arg Arg Leu Gln Asp Asp Leu Ala Thr Met Ala Arg 
            820                 825                 830         


Glu Asn Gln Glu Ile Ser Leu Glu Leu Glu Ala Ala Val Gln Glu Lys 
        835                 840                 845             


Glu Glu Met Lys Ser Arg Val His Lys Tyr Ile Thr Glu Val Ser Arg 
    850                 855                 860                 


Trp Glu Ser Leu Met Ala Ala Lys Glu Lys Glu Asn Gln Asp Leu Leu 
865                 870                 875                 880 


Asp Arg Phe Gln Met Leu His Asn Arg Ala Glu Asp Trp Glu Val Lys 
                885                 890                 895     


Ala His Gln Ala Glu Gly Glu Ser Ser Ser Val Arg Leu Glu Leu Leu 
            900                 905                 910         


Ser Ile Asp Thr Glu Arg Arg His Leu Arg Glu Arg Val Glu Leu Leu 
        915                 920                 925             


Glu Lys Glu Ile Gln Glu His Ile Asn Ala His His Ala Tyr Glu Ser 
    930                 935                 940                 


Gln Ile Ser Ser Met Ala Lys Ala Met Ser Arg Leu Glu Glu Glu Leu 
945                 950                 955                 960 


Arg His Gln Glu Asp Glu Lys Ala Thr Val Leu Asn Asp Leu Ser Ser 
                965                 970                 975     


Leu Arg Glu Leu Cys Ile Lys Leu Asp Ser Gly Lys Asp Ile Met Thr 
            980                 985                 990         


Gln Gln Leu Asn Ser Lys Asn Leu  Glu Phe Glu Arg Val  Val Val Glu 
        995                 1000                 1005             


Leu Glu  Asn Val Lys Ser Glu  Ser Asp Leu Leu Lys  Lys Gln Leu 
    1010                 1015                 1020             


Ser Asn  Glu Arg His Thr Val  Lys Asn Leu Glu Ser  Leu Leu Ala 
    1025                 1030                 1035             


Thr Asn  Arg Asp Lys Glu Phe  His Ser His Leu Thr  Ser His Glu 
    1040                 1045                 1050             


Lys Asp  Thr Glu Ile Gln Leu  Leu Lys Glu Lys Leu  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Lys Leu Thr Ser Gln  Ser Arg Glu Asn Thr  Met Leu Arg 
    1070                 1075                 1080             


Ala Lys  Val Ala Gln Leu Gln  Thr Asp Tyr Asp Ala  Leu Lys Arg 
    1085                 1090                 1095             


Gln Ile  Ser Thr Glu Arg Tyr  Glu Arg Glu Arg Ala  Ile Gln Glu 
    1100                 1105                 1110             


Met Arg  Arg His Gly Leu Ala  Thr Pro Pro Leu Ser  Ser Thr Leu 
    1115                 1120                 1125             


Arg Ser  Pro Ser His Ser Pro  Glu His Arg Asn Val  
    1130                 1135                 1140 


<210> 4850
<211> 503
<212> PRT
<213> Homo sapiens

<400> 4850
Met Pro Asn Val Ala Glu Thr Glu Arg Ser Asn Asp Ser Gly Asn Gly 
1               5                   10                  15      


Glu His Lys Ser Glu Arg Lys Ser Pro Glu Glu Asn Leu Gln Gly Ala 
            20                  25                  30          


Val Lys Ser Phe Cys Thr Ser Ala Ser Gly Ala Pro Leu Gly Pro Lys 
        35                  40                  45              


Gly Asp Gly His Tyr Pro Trp Ser Cys Pro Val Thr His Thr Arg Glu 
    50                  55                  60                  


Lys Ile Tyr Ala Ile Cys Ser Asp Tyr Ala Phe Leu Asn Gln Ala Thr 
65                  70                  75                  80  


Ser Ile Tyr Lys Thr Pro Asn Pro Ser Arg Ser Pro Cys Leu Pro Asp 
                85                  90                  95      


Ser Thr Ser Leu Ser Ala Gly Asn Asn Ser Ser Arg Tyr Ile Gly Ile 
            100                 105                 110         


Pro Thr Ser Thr Ser Glu Ile Ile Tyr Asn Glu Glu Asn Ser Leu Glu 
        115                 120                 125             


Asn Leu Ser Asn Ser Leu Gly Lys Leu Pro Leu Ala Trp Glu Ile Asp 
    130                 135                 140                 


Lys Ser Glu Phe Asp Gly Val Thr Thr Asn Ser Lys His Lys Ser Gly 
145                 150                 155                 160 


Asn Ala Lys Lys Gln Val Ser Lys Arg Lys Thr Ser Asp Lys Lys Gly 
                165                 170                 175     


Arg Tyr Gln Lys Glu Cys Pro Gln His Ser Pro Leu Glu Asp Ile Lys 
            180                 185                 190         


Gln Arg Lys Val Leu Asp Leu Arg Arg Trp Tyr Cys Ile Ser Arg Pro 
        195                 200                 205             


Gln Tyr Lys Thr Ser Cys Gly Ile Ser Ser Leu Ile Ser Cys Trp Asn 
    210                 215                 220                 


Phe Leu Tyr Ser Thr Met Gly Ala Gly Asn Leu Pro Pro Ile Thr Gln 
225                 230                 235                 240 


Glu Glu Ala Leu His Ile Leu Gly Phe Gln Pro Pro Phe Glu Asp Ile 
                245                 250                 255     


Arg Phe Gly Pro Phe Thr Gly Asn Thr Thr Leu Met Arg Trp Phe Arg 
            260                 265                 270         


Gln Ile Asn Asp His Phe His Val Lys Gly Cys Ser Tyr Val Leu Tyr 
        275                 280                 285             


Lys Pro His Gly Lys Asn Lys Thr Ala Gly Glu Thr Ala Ser Gly Ala 
    290                 295                 300                 


Leu Ser Lys Leu Thr Arg Gly Leu Lys Asp Glu Ser Leu Ala Tyr Ile 
305                 310                 315                 320 


Tyr His Cys Gln Asn His Tyr Phe Cys Pro Ile Gly Phe Glu Ala Thr 
                325                 330                 335     


Pro Val Lys Ala Asn Lys Ala Phe Ser Arg Gly Pro Leu Ser Pro Gln 
            340                 345                 350         


Glu Val Glu Tyr Trp Ile Leu Ile Gly Glu Ser Ser Arg Lys His Pro 
        355                 360                 365             


Ala Ile His Cys Lys Lys Trp Ala Asp Ile Val Thr Asp Leu Asn Thr 
    370                 375                 380                 


Gln Asn Pro Glu Tyr Leu Asp Ile Arg His Leu Glu Arg Gly Leu Gln 
385                 390                 395                 400 


Tyr Arg Lys Thr Lys Lys Val Gly Gly Asn Leu His Cys Ile Ile Ala 
                405                 410                 415     


Phe Gln Arg Leu Asn Trp Gln Arg Phe Gly Leu Trp Asn Phe Pro Phe 
            420                 425                 430         


Gly Thr Ile Arg Gln Glu Ser Gln Pro Pro Thr His Ala Gln Gly Ile 
        435                 440                 445             


Ala Lys Ser Glu Ser Glu Asp Asn Ile Ser Lys Lys Gln His Gly Arg 
    450                 455                 460                 


Leu Gly Arg Ser Phe Ser Ala Ser Phe His Gln Asp Ser Ala Trp Lys 
465                 470                 475                 480 


Lys Met Ser Ser Ile His Glu Arg Arg Asn Ser Gly Tyr Gln Gly Tyr 
                485                 490                 495     


Ser Asp Tyr Asp Gly Asn Asp 
            500             


<210> 4851
<211> 270
<212> PRT
<213> Homo sapiens

<400> 4851
Met Glu Ala Glu Glu Leu Glu Gln Glu Arg Glu Gln Leu Arg Leu Gln 
1               5                   10                  15      


Leu Trp Glu Ala Tyr Cys Gln Val Arg Tyr Leu Cys Ser His Leu Arg 
            20                  25                  30          


Gly Asn Asp Ser Ala Asp Ser Ala Val Ser Thr Asp Ser Ser Met Asp 
        35                  40                  45              


Glu Ser Ser Glu Thr Ser Ser Ala Lys Asp Val Pro Ala Gly Ser Leu 
    50                  55                  60                  


Arg Thr Ala Leu Asn Glu Leu Lys Arg Leu Ile Gln Ser Ile Val Asp 
65                  70                  75                  80  


Gly Met Glu Pro Thr Gly Ser Arg Arg Leu Asp Asp Asp Ser Leu Glu 
                85                  90                  95      


Glu Gln Ile Arg Gln Thr Ser Glu Asp Ser Arg Ala Leu Arg Glu Leu 
            100                 105                 110         


Met Glu Gly Glu Arg Gly Lys Leu Arg Gln Ser Leu Glu Glu Leu Gln 
        115                 120                 125             


Arg Leu His Ser Gln Val Thr Leu Leu Ser Val Glu Met Thr Ala Leu 
    130                 135                 140                 


Lys Glu Glu Arg Asp Arg Leu Arg Val Thr Ser Glu Asp Lys Glu Pro 
145                 150                 155                 160 


Lys Glu Gln Leu Gln Lys Ala Ile Arg Asp Arg Asp Glu Ala Ile Ala 
                165                 170                 175     


Lys Lys Asn Ala Val Glu Leu Glu Leu Ala Lys Cys Arg Met Asp Met 
            180                 185                 190         


Met Ser Leu Asn Ser Gln Leu Leu Asp Ala Ile Gln Gln Lys Leu Asn 
        195                 200                 205             


Leu Ser Gln Gln Leu Glu Ala Trp Gln Asp Asp Met His Arg Val Ile 
    210                 215                 220                 


Asp Arg Gln Leu Met Asp Thr His Leu Lys Glu Arg Ser Gln Pro Ala 
225                 230                 235                 240 


Ala Ala Leu Cys Arg Gly His Ser Ala Gly Arg Gly Asp Glu Pro Ser 
                245                 250                 255     


Ile Ala Glu Gly Lys Arg Leu Phe Ser Phe Phe Arg Lys Ile 
            260                 265                 270 


<210> 4852
<211> 792
<212> PRT
<213> Homo sapiens

<400> 4852
Met Leu Pro Ala Gly Glu Ile Gly Ala Ser Pro Ala Ala Pro Cys Cys 
1               5                   10                  15      


Ser Glu Ser Gly Asp Glu Arg Lys Asn Leu Glu Glu Lys Ser Asp Ile 
            20                  25                  30          


Asn Val Thr Val Leu Ile Gly Ser Lys Gln Val Ser Glu Gly Thr Asp 
        35                  40                  45              


Asn Gly Asp Leu Pro Ser Tyr Val Ser Ala Phe Ile Glu Lys Glu Val 
    50                  55                  60                  


Gly Asn Asp Leu Lys Ser Leu Lys Lys Leu Asp Lys Leu Ile Glu Gln 
65                  70                  75                  80  


Arg Thr Val Ser Lys Met Gln Leu Glu Glu Gln Val Leu Thr Ile Ser 
                85                  90                  95      


Ser Glu Ile Pro Lys Arg Ile Arg Ser Ala Leu Lys Asn Ala Glu Glu 
            100                 105                 110         


Ser Lys Gln Phe Leu Asn Gln Phe Leu Glu Gln Glu Thr His Leu Phe 
        115                 120                 125             


Ser Ala Ile Asn Ser His Leu Leu Thr Ala Gln Pro Trp Met Asp Asp 
    130                 135                 140                 


Leu Gly Thr Met Ile Ser Gln Ile Glu Glu Ile Glu Arg His Leu Ala 
145                 150                 155                 160 


Tyr Leu Lys Trp Ile Ser Gln Ile Glu Glu Leu Ser Asp Asn Ile Gln 
                165                 170                 175     


Gln Tyr Leu Met Thr Asn Asn Val Pro Glu Ala Ala Ser Thr Leu Val 
            180                 185                 190         


Ser Met Ala Glu Leu Asp Ile Lys Leu Gln Glu Ser Ser Cys Thr His 
        195                 200                 205             


Leu Leu Gly Phe Met Arg Ala Thr Val Lys Phe Trp His Lys Ile Leu 
    210                 215                 220                 


Lys Asp Lys Leu Thr Ser Asp Phe Glu Glu Ile Leu Ala Gln Leu His 
225                 230                 235                 240 


Trp Pro Phe Ile Ala Pro Pro Gln Ser Gln Thr Val Gly Leu Ser Arg 
                245                 250                 255     


Pro Ala Ser Ala Pro Glu Ile Tyr Ser Tyr Leu Glu Thr Leu Phe Cys 
            260                 265                 270         


Gln Leu Leu Lys Leu Gln Thr Ser Asp Glu Leu Leu Thr Glu Pro Lys 
        275                 280                 285             


Gln Leu Pro Glu Lys Tyr Ser Leu Pro Ala Ser Pro Ser Val Ile Leu 
    290                 295                 300                 


Pro Ile Gln Val Met Leu Thr Pro Leu Gln Lys Arg Phe Arg Tyr His 
305                 310                 315                 320 


Phe Arg Gly Asn Arg Gln Thr Asn Val Leu Ser Lys Pro Glu Trp Tyr 
                325                 330                 335     


Leu Ala Gln Val Leu Met Trp Ile Gly Asn His Thr Glu Phe Leu Asp 
            340                 345                 350         


Glu Lys Ile Gln Pro Ile Leu Asp Lys Val Gly Ser Leu Val Asn Ala 
        355                 360                 365             


Arg Leu Glu Phe Ser Arg Gly Leu Met Met Leu Val Leu Glu Lys Leu 
    370                 375                 380                 


Ala Thr Asp Ile Pro Cys Leu Leu Tyr Asp Asp Asn Leu Phe Cys His 
385                 390                 395                 400 


Leu Val Asp Glu Val Leu Leu Phe Glu Arg Glu Leu His Ser Val His 
                405                 410                 415     


Gly Tyr Pro Gly Thr Phe Ala Ser Cys Met His Ile Leu Ser Glu Glu 
            420                 425                 430         


Thr Cys Phe Gln Arg Trp Leu Thr Val Glu Arg Lys Phe Ala Leu Gln 
        435                 440                 445             


Lys Met Asp Ser Met Leu Ser Ser Glu Ala Ala Trp Val Ser Gln Tyr 
    450                 455                 460                 


Lys Asp Ile Thr Asp Val Asp Glu Met Lys Val Pro Asp Cys Ala Glu 
465                 470                 475                 480 


Thr Phe Met Thr Leu Leu Leu Val Ile Thr Asp Arg Tyr Lys Asn Leu 
                485                 490                 495     


Pro Thr Ala Ser Arg Lys Leu Gln Phe Leu Glu Leu Gln Lys Asp Leu 
            500                 505                 510         


Val Asp Asp Phe Arg Ile Arg Leu Thr Gln Val Met Lys Glu Glu Thr 
        515                 520                 525             


Arg Ala Ser Leu Gly Phe Arg Tyr Cys Ala Ile Leu Asn Ala Val Asn 
    530                 535                 540                 


Tyr Ile Ser Thr Val Leu Ala Asp Trp Ala Asp Asn Val Phe Phe Leu 
545                 550                 555                 560 


Gln Leu Gln Gln Ala Ala Leu Glu Val Phe Ala Glu Asn Asn Thr Leu 
                565                 570                 575     


Ser Lys Leu Gln Leu Gly Gln Leu Ala Ser Met Glu Ser Ser Val Phe 
            580                 585                 590         


Asp Asp Met Ile Asn Leu Leu Glu Arg Leu Lys His Asp Met Leu Thr 
        595                 600                 605             


Arg Gln Val Asp His Val Phe Arg Glu Val Lys Asp Ala Ala Lys Leu 
    610                 615                 620                 


Tyr Lys Lys Glu Arg Trp Leu Ser Leu Pro Ser Gln Ser Glu Gln Ala 
625                 630                 635                 640 


Val Met Ser Leu Ser Ser Ser Ala Cys Pro Leu Leu Leu Thr Leu Arg 
                645                 650                 655     


Asp His Leu Leu Gln Leu Glu Gln Gln Leu Cys Phe Ser Leu Phe Lys 
            660                 665                 670         


Ile Phe Trp Gln Met Leu Val Glu Lys Leu Asp Val Tyr Ile Tyr Gln 
        675                 680                 685             


Glu Ile Ile Leu Ala Asn His Phe Asn Glu Gly Gly Ala Ala Gln Leu 
    690                 695                 700                 


Gln Phe Asp Met Thr Arg Asn Leu Phe Pro Leu Phe Ser His Tyr Cys 
705                 710                 715                 720 


Lys Arg Pro Glu Asn Tyr Phe Lys His Ile Lys Glu Ala Cys Ile Val 
                725                 730                 735     


Leu Asn Leu Asn Val Gly Ser Ala Leu Leu Leu Lys Asp Val Leu Gln 
            740                 745                 750         


Ser Ala Ser Gly Gln Leu Pro Ala Thr Ala Ala Leu Asn Glu Val Gly 
        755                 760                 765             


Ile Tyr Lys Leu Ala Gln Gln Asp Val Glu Ile Leu Leu Asn Leu Arg 
    770                 775                 780                 


Thr Asn Trp Pro Asn Thr Gly Lys 
785                 790         


<210> 4853
<211> 355
<212> PRT
<213> Homo sapiens

<400> 4853
Val Arg Gly Val Arg Ala Ala Thr Ala Ala Ala Val Ala Ala Thr Ala 
1               5                   10                  15      


Ala Ser Gly Leu Ser Arg Arg Glu Ala Gly Gly Arg Ala Gly Ala Ala 
            20                  25                  30          


Ala Ala Val Val Arg Pro Pro Gly Arg Lys Cys Gly Arg Cys Arg Arg 
        35                  40                  45              


Leu Ala Asn Phe Pro Gly Arg Lys Arg Arg Arg Arg Arg Arg Lys Gly 
    50                  55                  60                  


Leu Gly Ala Thr Thr Gly Gly Cys Gly Glu Ala Val Ser Ser Leu His 
65                  70                  75                  80  


Pro Ala Pro His Ser Pro Ser Ser Val Arg Pro Ala Gly Arg Arg Ala 
                85                  90                  95      


Arg Arg Gln Arg Arg Gly Ala Gly Ser Ala Glu Arg Pro Met Ser Gly 
            100                 105                 110         


Ala Gly Glu Ala Leu Ala Pro Gly Pro Val Gly Pro Gln Arg Val Ala 
        115                 120                 125             


Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala Gln Gly Lys Cys Asp 
    130                 135                 140                 


Lys Asp Asn Thr Glu Lys Asp Ile Thr Gln Ala Thr Asn Ser His Phe 
145                 150                 155                 160 


Thr His Gly Glu Met Gln Asp Gln Ser Ile Trp Gly Asn Pro Ser Asp 
                165                 170                 175     


Gly Glu Leu Ile Arg Thr Gln Pro Gln Arg Leu Pro Gln Leu Gln Thr 
            180                 185                 190         


Ser Ala Gln Val Pro Ser Gly Glu Glu Ile Gly Lys Ile Lys Asn Gly 
        195                 200                 205             


His Thr Gly Leu Ser Asn Gly Asn Gly Ile His His Gly Ala Lys His 
    210                 215                 220                 


Gly Ser Ala Asp Asn Arg Lys Leu Ser Ala Pro Val Ser Gln Lys Met 
225                 230                 235                 240 


His Arg Lys Ile Gln Ser Ser Leu Ser Val Asn Ser Asp Ile Ser Lys 
                245                 250                 255     


Lys Ser Lys Val Asn Ala Val Phe Ser Gln Lys Thr Gly Ser Ser Pro 
            260                 265                 270         


Glu Asp Cys Cys Val His Cys Ile Leu Ala Cys Leu Phe Cys Glu Phe 
        275                 280                 285             


Leu Thr Leu Cys Asn Ile Val Leu Gly Gln Ala Ser Cys Gly Ile Cys 
    290                 295                 300                 


Thr Ser Glu Ala Cys Cys Cys Cys Cys Gly Asp Glu Met Gly Asp Asp 
305                 310                 315                 320 


Cys Asn Cys Pro Cys Asp Met Asp Cys Gly Ile Met Asp Ala Cys Cys 
                325                 330                 335     


Glu Ser Ser Asp Cys Leu Glu Ile Cys Met Glu Cys Cys Gly Ile Cys 
            340                 345                 350         


Phe Pro Ser 
        355 


<210> 4854
<211> 125
<212> PRT
<213> Homo sapiens

<400> 4854
Met Leu Ser Arg Leu Leu Lys Glu His Gln Ala Lys Gln Asn Glu Arg 
1               5                   10                  15      


Lys Glu Leu Gln Glu Lys Arg Arg Arg Glu Ala Ile Thr Ala Ala Thr 
            20                  25                  30          


Cys Leu Thr Glu Ala Leu Val Asp His Leu Asn Val Gly Val Ala Gln 
        35                  40                  45              


Ala Tyr Met Asn Gln Arg Lys Leu Asp His Glu Val Lys Thr Leu Gln 
    50                  55                  60                  


Val Gln Ala Ala Gln Phe Ala Lys Gln Thr Gly Gln Trp Ile Gly Met 
65                  70                  75                  80  


Val Glu Asn Phe Asn Gln Ala Leu Lys Glu Ile Gly Asp Val Glu Asn 
                85                  90                  95      


Trp Ala Arg Ser Ile Glu Leu Asp Met Arg Thr Ile Ala Thr Ala Leu 
            100                 105                 110         


Glu Tyr Val Tyr Lys Gly Gln Leu Gln Ser Ala Pro Ser 
        115                 120                 125 


<210> 4855
<211> 778
<212> PRT
<213> Homo sapiens

<400> 4855
Met Thr Thr Arg Gln Ala Thr Lys Asp Pro Leu Leu Arg Gly Val Ser 
1               5                   10                  15      


Pro Thr Pro Ser Lys Ile Pro Val Arg Ser Gln Lys Arg Thr Pro Phe 
            20                  25                  30          


Pro Thr Val Thr Ser Cys Ala Val Asp Gln Glu Asn Gln Asp Pro Arg 
        35                  40                  45              


Arg Trp Val Gln Lys Pro Pro Leu Asn Ile Gln Arg Pro Leu Val Asp 
    50                  55                  60                  


Ser Ala Gly Pro Arg Pro Lys Ala Arg His Gln Ala Glu Thr Ser Gln 
65                  70                  75                  80  


Arg Leu Val Gly Ile Ser Gln Pro Arg Asn Pro Leu Glu Glu Leu Arg 
                85                  90                  95      


Pro Ser Pro Arg Gly Gln Asn Val Gly Pro Gly Pro Pro Ala Gln Thr 
            100                 105                 110         


Glu Ala Pro Gly Thr Ile Glu Phe Val Ala Asp Pro Ala Ala Leu Ala 
        115                 120                 125             


Thr Ile Leu Ser Gly Glu Gly Val Lys Ser Cys His Leu Gly Arg Gln 
    130                 135                 140                 


Pro Ser Leu Ala Lys Arg Val Leu Val Arg Gly Ser Gln Gly Gly Thr 
145                 150                 155                 160 


Thr Gln Arg Val Gln Gly Val Arg Ala Ser Ala Tyr Leu Ala Pro Arg 
                165                 170                 175     


Thr Pro Thr His Arg Leu Asp Pro Ala Arg Ala Ser Cys Phe Ser Arg 
            180                 185                 190         


Leu Glu Gly Pro Gly Pro Arg Gly Arg Thr Leu Cys Pro Gln Arg Leu 
        195                 200                 205             


Gln Ala Leu Ile Ser Pro Ser Gly Pro Ser Phe His Pro Ser Thr Arg 
    210                 215                 220                 


Pro Ser Phe Gln Glu Leu Arg Arg Glu Thr Ala Gly Ser Ser Arg Thr 
225                 230                 235                 240 


Ser Val Ser Gln Ala Ser Gly Leu Leu Leu Glu Thr Pro Val Gln Pro 
                245                 250                 255     


Ala Phe Ser Leu Pro Lys Gly Glu Arg Glu Val Val Thr His Ser Asp 
            260                 265                 270         


Glu Gly Gly Val Ala Ser Leu Gly Leu Ala Gln Arg Val Pro Leu Arg 
        275                 280                 285             


Glu Asn Arg Glu Met Ser His Thr Arg Asp Ser His Asp Ser His Leu 
    290                 295                 300                 


Met Pro Ser Pro Ala Pro Val Ala Gln Pro Leu Pro Gly His Val Val 
305                 310                 315                 320 


Pro Cys Pro Ser Pro Phe Gly Arg Ala Gln Arg Val Pro Ser Pro Gly 
                325                 330                 335     


Pro Pro Thr Leu Thr Ser Tyr Ser Val Leu Arg Arg Leu Thr Val Gln 
            340                 345                 350         


Pro Lys Thr Arg Phe Thr Pro Met Pro Ser Thr Pro Arg Val Gln Gln 
        355                 360                 365             


Ala Gln Trp Leu Arg Gly Val Ser Pro Gln Ser Cys Ser Glu Asp Pro 
    370                 375                 380                 


Ala Leu Pro Trp Glu Gln Val Ala Val Arg Leu Phe Asp Gln Glu Ser 
385                 390                 395                 400 


Cys Ile Arg Ser Leu Glu Gly Ser Gly Lys Pro Pro Val Ala Thr Pro 
                405                 410                 415     


Ser Gly Pro His Ser Asn Arg Thr Pro Ser Leu Gln Glu Val Lys Ile 
            420                 425                 430         


Gln Arg Ile Gly Ile Leu Gln Gln Leu Leu Arg Gln Glu Val Glu Gly 
        435                 440                 445             


Leu Val Gly Gly Gln Cys Val Pro Leu Asn Gly Gly Ser Ser Leu Asp 
    450                 455                 460                 


Met Val Glu Leu Gln Pro Leu Leu Thr Glu Ile Ser Arg Thr Leu Asn 
465                 470                 475                 480 


Ala Thr Glu His Asn Ser Gly Thr Ser His Leu Pro Gly Leu Leu Lys 
                485                 490                 495     


His Ser Gly Leu Pro Lys Pro Cys Leu Pro Glu Glu Cys Gly Glu Pro 
            500                 505                 510         


Gln Pro Cys Pro Pro Ala Glu Pro Gly Pro Pro Glu Ala Phe Cys Arg 
        515                 520                 525             


Ser Glu Pro Glu Ile Pro Glu Pro Ser Leu Gln Glu Gln Leu Glu Val 
    530                 535                 540                 


Pro Glu Pro Tyr Pro Pro Ala Glu Pro Arg Pro Leu Glu Ser Cys Cys 
545                 550                 555                 560 


Arg Ser Glu Pro Glu Ile Pro Glu Ser Ser Arg Gln Glu Gln Leu Glu 
                565                 570                 575     


Val Pro Glu Pro Cys Pro Pro Ala Glu Pro Arg Pro Leu Glu Ser Tyr 
            580                 585                 590         


Cys Arg Ile Glu Pro Glu Ile Pro Glu Ser Ser Arg Gln Glu Gln Leu 
        595                 600                 605             


Glu Val Pro Glu Pro Cys Pro Pro Ala Glu Pro Gly Pro Leu Gln Pro 
    610                 615                 620                 


Ser Thr Gln Gly Gln Ser Gly Pro Pro Gly Pro Cys Pro Arg Val Glu 
625                 630                 635                 640 


Leu Gly Ala Ser Glu Pro Cys Thr Leu Glu His Arg Ser Leu Glu Ser 
                645                 650                 655     


Ser Leu Pro Pro Cys Cys Ser Gln Trp Ala Pro Ala Thr Thr Ser Leu 
            660                 665                 670         


Ile Phe Ser Ser Gln His Pro Leu Cys Ala Ser Pro Pro Ile Cys Ser 
        675                 680                 685             


Leu Gln Ser Leu Arg Pro Pro Ala Gly Gln Ala Gly Leu Ser Asn Leu 
    690                 695                 700                 


Ala Pro Arg Thr Leu Ala Leu Arg Glu Arg Leu Lys Ser Cys Leu Thr 
705                 710                 715                 720 


Ala Ile His Cys Phe His Glu Ala Arg Leu Asp Asp Glu Cys Ala Phe 
                725                 730                 735     


Tyr Thr Ser Arg Ala Pro Pro Ser Gly Pro Thr Arg Val Cys Thr Asn 
            740                 745                 750         


Pro Val Ala Thr Leu Leu Glu Trp Gln Asp Ala Leu Cys Phe Ile Pro 
        755                 760                 765             


Val Gly Ser Ala Ala Pro Gln Gly Ser Pro 
    770                 775             


<210> 4856
<211> 600
<212> PRT
<213> Homo sapiens

<400> 4856
Met Ser Cys Arg Ser Tyr Arg Val Ser Ser Gly His Arg Val Gly Asn 
1               5                   10                  15      


Phe Ser Ser Cys Ser Ala Met Thr Pro Gln Asn Leu Asn Arg Phe Arg 
            20                  25                  30          


Ala Asn Ser Val Ser Cys Trp Ser Gly Pro Gly Phe Arg Gly Leu Gly 
        35                  40                  45              


Ser Phe Gly Ser Arg Ser Val Ile Thr Phe Gly Ser Tyr Ser Pro Arg 
    50                  55                  60                  


Ile Ala Ala Val Gly Ser Arg Pro Ile His Cys Gly Val Arg Phe Gly 
65                  70                  75                  80  


Ala Gly Cys Gly Met Gly Phe Gly Asp Gly Arg Gly Val Gly Leu Gly 
                85                  90                  95      


Pro Arg Ala Asp Ser Cys Val Gly Leu Gly Phe Gly Ala Gly Ser Gly 
            100                 105                 110         


Ile Gly Tyr Gly Phe Gly Gly Pro Gly Phe Gly Tyr Arg Val Gly Gly 
        115                 120                 125             


Val Gly Val Pro Ala Ala Pro Ser Ile Thr Ala Val Thr Val Asn Lys 
    130                 135                 140                 


Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp Pro Asn Ala Gln Arg 
145                 150                 155                 160 


Val Lys Lys Asp Glu Lys Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe 
                165                 170                 175     


Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Leu 
            180                 185                 190         


Leu Glu Thr Lys Trp Ser Phe Leu Gln Glu Gln Lys Cys Ile Arg Ser 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Ser Tyr Ile Thr Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Glu Val Leu Val Ser Asp Gln Ala Arg Leu Gln Ala Glu Arg Asn 
225                 230                 235                 240 


His Leu Gln Asp Val Leu Glu Gly Phe Lys Lys Lys Tyr Glu Glu Glu 
                245                 250                 255     


Val Val Cys Arg Ala Asn Ala Glu Asn Glu Phe Val Ala Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Phe Met Asn Lys Ser Asp Leu Glu Ala Asn Val 
        275                 280                 285             


Asp Thr Leu Thr Gln Glu Ile Asp Phe Leu Lys Thr Leu Tyr Met Glu 
    290                 295                 300                 


Glu Ile Gln Leu Leu Gln Ser His Ile Ser Glu Thr Ser Val Ile Val 
305                 310                 315                 320 


Lys Met Asp Asn Ser Arg Asp Leu Asn Leu Asp Gly Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Val Ala Arg Arg Ser Arg Ala Asp Ala 
            340                 345                 350         


Glu Ala Trp Tyr Gln Thr Lys Tyr Glu Glu Met Gln Val Thr Ala Gly 
        355                 360                 365             


Gln His Cys Asp Asn Leu Arg Asn Ile Arg Asn Glu Ile Asn Glu Leu 
    370                 375                 380                 


Thr Arg Leu Ile Gln Arg Leu Lys Ala Glu Ile Glu His Ala Lys Ala 
385                 390                 395                 400 


Gln Arg Ala Lys Leu Glu Ala Ala Val Ala Glu Ala Glu Gln Gln Gly 
                405                 410                 415     


Glu Ala Thr Leu Ser Asp Ala Lys Cys Lys Leu Ala Asp Leu Glu Cys 
            420                 425                 430         


Ala Leu Gln Gln Ala Lys Gln Asp Met Ala Arg Gln Leu Cys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Ala Lys Leu Gly Leu Asp Ile Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Arg Leu Leu Glu Gly Glu Glu Ser Arg Leu Cys Glu Gly Val 
465                 470                 475                 480 


Gly Pro Val Asn Ile Ser Val Ser Ser Ser Arg Gly Gly Leu Val Cys 
                485                 490                 495     


Gly Pro Glu Pro Leu Val Ala Gly Ser Thr Leu Ser Arg Gly Gly Val 
            500                 505                 510         


Thr Phe Ser Gly Ser Ser Ser Val Cys Ala Thr Ser Gly Val Leu Ala 
        515                 520                 525             


Ser Cys Gly Pro Ser Leu Gly Gly Ala Arg Val Ala Pro Ala Thr Gly 
    530                 535                 540                 


Asp Leu Leu Ser Thr Gly Thr Arg Ser Gly Ser Met Leu Ile Ser Glu 
545                 550                 555                 560 


Ala Cys Val Pro Ser Val Pro Cys Pro Leu Pro Thr Gln Gly Gly Phe 
                565                 570                 575     


Ser Ser Cys Ser Gly Gly Arg Ser Ser Ser Val Arg Phe Val Ser Thr 
            580                 585                 590         


Thr Thr Ser Cys Arg Thr Lys Tyr 
        595                 600 


<210> 4857
<211> 513
<212> PRT
<213> Homo sapiens

<400> 4857
Met Ser Tyr His Ser Phe Gln Pro Gly Ser Arg Cys Gly Ser Gln Ser 
1               5                   10                  15      


Phe Ser Ser Tyr Ser Ala Val Met Pro Arg Met Val Thr His Tyr Ala 
            20                  25                  30          


Val Ser Lys Gly Pro Cys Arg Pro Gly Gly Gly Arg Gly Leu Arg Ala 
        35                  40                  45              


Leu Gly Cys Leu Gly Ser Arg Ser Leu Cys Asn Val Gly Phe Gly Arg 
    50                  55                  60                  


Pro Arg Val Ala Ser Arg Cys Gly Gly Thr Leu Pro Gly Phe Gly Tyr 
65                  70                  75                  80  


Arg Leu Gly Ala Thr Cys Gly Pro Ser Ala Cys Ile Thr Pro Val Thr 
                85                  90                  95      


Ile Asn Glu Ser Leu Leu Val Pro Leu Ala Leu Glu Ile Asp Pro Thr 
            100                 105                 110         


Val Gln Arg Val Lys Arg Asp Glu Lys Glu Gln Ile Lys Cys Leu Asn 
        115                 120                 125             


Asn Arg Phe Ala Ser Phe Ile Asn Lys Val Arg Phe Leu Glu Gln Lys 
    130                 135                 140                 


Asn Lys Leu Leu Glu Thr Lys Trp Asn Phe Met Gln Gln Gln Arg Cys 
145                 150                 155                 160 


Cys Gln Thr Asn Ile Glu Pro Ile Phe Glu Gly Tyr Ile Ser Ala Leu 
                165                 170                 175     


Arg Arg Gln Leu Asp Cys Val Ser Gly Asp Arg Val Arg Leu Glu Ser 
            180                 185                 190         


Glu Leu Cys Ser Leu Gln Ala Ala Leu Glu Gly Tyr Lys Lys Lys Tyr 
        195                 200                 205             


Glu Glu Glu Leu Ser Leu Arg Pro Cys Val Glu Asn Glu Phe Val Ala 
    210                 215                 220                 


Leu Lys Lys Asp Val Asp Thr Ala Phe Leu Met Lys Ala Asp Leu Glu 
225                 230                 235                 240 


Thr Asn Ala Glu Ala Leu Val Gln Glu Ile Asp Phe Leu Lys Ser Leu 
                245                 250                 255     


Tyr Glu Glu Glu Ile Cys Leu Leu Gln Ser Gln Ile Ser Glu Thr Ser 
            260                 265                 270         


Val Ile Val Lys Met Asp Asn Ser Arg Glu Leu Asp Val Asp Gly Ile 
        275                 280                 285             


Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Ala Ser Arg Ser Lys 
    290                 295                 300                 


Ala Glu Ala Glu Ala Trp Tyr Gln Cys Arg Tyr Glu Glu Leu Arg Val 
305                 310                 315                 320 


Thr Ala Gly Asn His Cys Asp Asn Leu Arg Asn Arg Lys Asn Glu Ile 
                325                 330                 335     


Leu Glu Met Asn Lys Leu Ile Gln Arg Leu Gln Gln Glu Thr Glu Asn 
            340                 345                 350         


Val Lys Ala Gln Arg Cys Lys Leu Glu Gly Ala Ile Ala Glu Ala Glu 
        355                 360                 365             


Gln Gln Gly Glu Ala Ala Leu Asn Asp Ala Lys Cys Lys Leu Ala Gly 
    370                 375                 380                 


Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys Leu Leu 
385                 390                 395                 400 


Lys Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp Ile Glu 
                405                 410                 415     


Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu His Arg Leu Cys 
            420                 425                 430         


Glu Gly Ile Gly Pro Val Asn Ile Ser Val Ser Ser Ser Lys Gly Ala 
        435                 440                 445             


Phe Leu Tyr Glu Pro Cys Gly Val Ser Thr Pro Val Leu Ser Thr Gly 
    450                 455                 460                 


Val Leu Arg Ser Asn Gly Gly Cys Ser Ile Val Gly Thr Gly Glu Leu 
465                 470                 475                 480 


Tyr Val Pro Cys Glu Pro Gln Gly Leu Leu Ser Cys Gly Ser Gly Arg 
                485                 490                 495     


Lys Ser Ser Met Thr Leu Gly Ala Gly Gly Ser Ser Pro Ser His Lys 
            500                 505                 510         


His 
    


<210> 4858
<211> 543
<212> PRT
<213> Homo sapiens

<400> 4858
Met Met Pro Thr Pro Val Ile Leu Leu Lys Glu Gly Thr Asp Ser Ser 
1               5                   10                  15      


Gln Gly Ile Pro Gln Leu Val Ser Asn Ile Ser Ala Cys Gln Val Ile 
            20                  25                  30          


Ala Glu Ala Val Arg Thr Thr Leu Gly Pro Arg Gly Met Asp Lys Leu 
        35                  40                  45              


Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn Asp Gly Ala Thr 
    50                  55                  60                  


Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala Lys Thr Leu Val 
65                  70                  75                  80  


Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp Gly Thr Thr Ser 
                85                  90                  95      


Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val 
            100                 105                 110         


Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala 
        115                 120                 125             


Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys 
    130                 135                 140                 


Lys Ala Asp Lys Val Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met 
145                 150                 155                 160 


Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala 
                165                 170                 175     


Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu 
            180                 185                 190         


Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Asp Ser 
        195                 200                 205             


Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly 
    210                 215                 220                 


Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys Ile Ala Leu Leu 
225                 230                 235                 240 


Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg 
                245                 250                 255     


Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn 
            260                 265                 270         


Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser Gly Ala Lys Val 
        275                 280                 285             


Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala 
    290                 295                 300                 


Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys 
305                 310                 315                 320 


Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala 
                325                 330                 335     


Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln 
            340                 345                 350         


Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys 
        355                 360                 365             


Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu 
    370                 375                 380                 


Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile 
385                 390                 395                 400 


Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu 
                405                 410                 415     


Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln 
            420                 425                 430         


Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln 
        435                 440                 445             


Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu 
    450                 455                 460                 


Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly Val Asp Ile Asn 
465                 470                 475                 480 


Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala 
                485                 490                 495     


Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu 
            500                 505                 510         


Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp 
        515                 520                 525             


Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His 
    530                 535                 540             


<210> 4859
<211> 492
<212> PRT
<213> Homo sapiens

<400> 4859
Met Ala Pro Val Gly Val Glu Lys Lys Leu Leu Leu Gly Pro Asn Gly 
1               5                   10                  15      


Pro Ala Val Ala Ala Ala Gly Asp Leu Thr Ser Glu Glu Glu Glu Gly 
            20                  25                  30          


Gln Ser Leu Trp Ser Ser Ile Leu Ser Glu Val Ser Thr Arg Ala Arg 
        35                  40                  45              


Ser Lys Leu Pro Ser Gly Lys Asn Ile Leu Val Phe Gly Glu Asp Gly 
    50                  55                  60                  


Ser Gly Lys Thr Thr Leu Met Thr Lys Leu Gln Gly Ala Glu His Gly 
65                  70                  75                  80  


Lys Lys Gly Arg Gly Leu Glu Tyr Leu Tyr Leu Ser Val His Asp Glu 
                85                  90                  95      


Asp Arg Asp Asp His Thr Arg Cys Asn Val Trp Ile Leu Asp Gly Asp 
            100                 105                 110         


Leu Tyr His Lys Gly Leu Leu Lys Phe Ala Val Ser Ala Glu Ser Leu 
        115                 120                 125             


Pro Glu Thr Leu Val Ile Phe Val Ala Asp Met Ser Arg Pro Trp Thr 
    130                 135                 140                 


Val Met Glu Ser Leu Gln Lys Trp Ala Ser Val Leu Arg Glu His Ile 
145                 150                 155                 160 


Asp Lys Met Lys Ile Pro Pro Glu Lys Met Arg Glu Leu Glu Arg Lys 
                165                 170                 175     


Phe Val Lys Asp Phe Gln Asp Tyr Met Glu Pro Glu Glu Gly Cys Gln 
            180                 185                 190         


Gly Ser Pro Gln Arg Arg Gly Pro Leu Thr Ser Gly Ser Asp Glu Glu 
        195                 200                 205             


Asn Val Ala Leu Pro Leu Gly Asp Asn Val Leu Thr His Asn Leu Gly 
    210                 215                 220                 


Ile Pro Val Leu Val Val Cys Thr Lys Cys Asp Ala Val Ser Val Leu 
225                 230                 235                 240 


Glu Lys Glu His Asp Tyr Arg Asp Glu His Leu Asp Phe Ile Gln Ser 
                245                 250                 255     


His Leu Arg Arg Phe Cys Leu Gln Tyr Gly Ala Ala Leu Ile Tyr Thr 
            260                 265                 270         


Ser Val Lys Glu Glu Lys Asn Leu Asp Leu Leu Tyr Lys Tyr Ile Val 
        275                 280                 285             


His Lys Thr Tyr Gly Phe His Phe Thr Thr Pro Ala Leu Val Val Glu 
    290                 295                 300                 


Lys Asp Ala Val Phe Ile Pro Ala Gly Trp Asp Asn Glu Lys Lys Ile 
305                 310                 315                 320 


Ala Ile Leu His Glu Asn Phe Thr Thr Val Lys Pro Glu Asp Ala Tyr 
                325                 330                 335     


Glu Asp Phe Ile Val Lys Pro Pro Val Arg Lys Leu Val His Asp Lys 
            340                 345                 350         


Glu Leu Ala Ala Glu Asp Glu Gln Val Phe Leu Met Lys Gln Gln Ser 
        355                 360                 365             


Leu Leu Ala Lys Gln Pro Ala Thr Pro Thr Arg Ala Ser Glu Ser Pro 
    370                 375                 380                 


Ala Arg Gly Pro Ser Gly Ser Pro Arg Thr Gln Gly Arg Gly Gly Pro 
385                 390                 395                 400 


Ala Ser Val Pro Ser Ser Ser Pro Gly Thr Ser Val Lys Lys Pro Asp 
                405                 410                 415     


Pro Asn Ile Lys Asn Asn Ala Ala Ser Glu Gly Val Leu Ala Ser Phe 
            420                 425                 430         


Phe Asn Ser Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly Ser Pro Gly 
        435                 440                 445             


Ala Gly Gly Val Gln Ser Thr Ala Lys Lys Ser Gly Gln Lys Thr Val 
    450                 455                 460                 


Leu Ser Asn Val Gln Glu Glu Leu Asp Arg Met Thr Arg Lys Pro Asp 
465                 470                 475                 480 


Ser Met Val Thr Asn Ser Ser Thr Glu Asn Glu Ala 
                485                 490         


<210> 4860
<211> 179
<212> PRT
<213> Homo sapiens

<400> 4860
Met Asp Lys Asp Phe Asp Lys Leu His Glu Phe Val Glu Ile Met Lys 
1               5                   10                  15      


Glu Met Gln Lys Asp Met Asp Glu Lys Met Asp Ile Leu Ile Asn Thr 
            20                  25                  30          


Gln Lys Asn Tyr Lys Leu Pro Leu Arg Arg Ala Pro Lys Glu Gln Gln 
        35                  40                  45              


Glu Leu Arg Leu Met Gly Lys Thr His Arg Glu Pro Gln Leu Arg Pro 
    50                  55                  60                  


Lys Lys Met Asp Gly Ala Ser Gly Val Asn Gly Ala Pro Cys Ala Leu 
65                  70                  75                  80  


His Lys Lys Thr Met Ala Pro Gln Lys Thr Lys Gln Gly Ser Leu Asp 
                85                  90                  95      


Pro Leu His His Cys Gly Thr Cys Cys Glu Lys Cys Leu Leu Cys Ala 
            100                 105                 110         


Leu Lys Asn Asn Tyr Asn Arg Ala Ala Pro Leu Lys Glu Ala Arg His 
        115                 120                 125             


Leu Leu Thr Ala Asn Ser Ile Asp Pro Ser Ala Ala Leu Val Leu Leu 
    130                 135                 140                 


Ile Glu Phe Leu Leu Leu Thr Leu Val Thr Gly Ala Ala Ala Pro Gly 
145                 150                 155                 160 


Leu Asp Ala Cys Gly His Gln Arg Asn Met Arg Asp Glu Ile Asn Ser 
                165                 170                 175     


Glu Arg Arg 
            


<210> 4861
<211> 1199
<212> PRT
<213> Homo sapiens

<400> 4861
Met Ala Ser Ala Gly Thr Gln His Tyr Ser Ile Gly Leu Arg Gln Lys 
1               5                   10                  15      


Asn Ser Phe Lys Gln Ser Gly Pro Ser Gly Thr Val Pro Ala Thr Pro 
            20                  25                  30          


Pro Glu Lys Pro Ser Glu Gly Arg Val Trp Pro Gln Ala His Gln Gln 
        35                  40                  45              


Val Lys Pro Ile Trp Lys Leu Glu Lys Lys Gln Val Glu Thr Leu Ser 
    50                  55                  60                  


Ala Gly Leu Gly Pro Gly Leu Leu Gly Val Pro Pro Gln Pro Ala Tyr 
65                  70                  75                  80  


Phe Phe Cys Pro Ser Thr Leu Cys Ser Ser Gly Thr Thr Ala Val Ile 
                85                  90                  95      


Ala Gly His Ser Ser Ser Cys Tyr Leu His Ser Leu Pro Asp Leu Phe 
            100                 105                 110         


Asn Ser Thr Leu Leu Tyr Arg Arg Ser Ser Tyr Arg Gln Lys Pro Tyr 
        115                 120                 125             


Gln Gln Leu Glu Ser Phe Cys Leu Arg Ser Ser Pro Ser Glu Lys Ser 
    130                 135                 140                 


Pro Phe Ser Leu Pro Gln Lys Ser Leu Pro Val Ser Leu Thr Ala Asn 
145                 150                 155                 160 


Lys Ala Thr Ser Ser Met Val Phe Ser Met Ala Gln Pro Met Ala Ser 
                165                 170                 175     


Ser Ser Thr Glu Pro Tyr Leu Cys Leu Ala Ala Ala Gly Glu Asn Pro 
            180                 185                 190         


Ser Gly Lys Ser Leu Ala Ser Ala Ile Ser Gly Lys Ile Pro Ser Pro 
        195                 200                 205             


Leu Ser Ser Ser Tyr Lys Pro Met Leu Asn Asn Asn Ser Phe Met Trp 
    210                 215                 220                 


Pro Asn Ser Thr Pro Val Pro Leu Leu Gln Thr Thr Gln Gly Leu Lys 
225                 230                 235                 240 


Pro Val Ser Pro Pro Lys Ile Gln Pro Val Ser Trp His His Ser Gly 
                245                 250                 255     


Gly Thr Gly Asp Cys Ala Pro Gln Pro Val Asp His Lys Val Pro Lys 
            260                 265                 270         


Ser Ile Gly Thr Val Pro Ala Asp Ala Ser Ala His Ile Ala Leu Ser 
        275                 280                 285             


Thr Ala Ser Ser His Asp Thr Ser Thr Thr Ser Val Ala Ser Ser Trp 
    290                 295                 300                 


Tyr Asn Arg Asn Asn Leu Ala Met Arg Ala Glu Pro Leu Ser Cys Ala 
305                 310                 315                 320 


Leu Asp Asp Ser Ser Asp Ser Gln Asp Pro Thr Lys Glu Ile Arg Phe 
                325                 330                 335     


Thr Glu Ala Val Arg Lys Leu Thr Ala Arg Gly Phe Glu Lys Met Pro 
            340                 345                 350         


Arg Gln Gly Cys Gln Leu Glu Gln Ser Ser Phe Leu Asn Pro Ser Phe 
        355                 360                 365             


Gln Trp Asn Val Leu Asn Arg Ser Arg Arg Trp Lys Pro Pro Ala Val 
    370                 375                 380                 


Asn Gln Gln Phe Pro Gln Glu Asp Ala Gly Ser Val Arg Arg Val Leu 
385                 390                 395                 400 


Pro Gly Ala Ser Asp Thr Leu Gly Leu Asp Asn Thr Val Phe Cys Thr 
                405                 410                 415     


Lys Arg Ile Ser Ile His Leu Leu Ala Ser His Ala Ser Gly Leu Asn 
            420                 425                 430         


His Asn Pro Ala Cys Glu Ser Val Ile Asp Ser Ser Ala Phe Gly Glu 
        435                 440                 445             


Gly Lys Ala Pro Gly Pro Pro Phe Pro Gln Thr Leu Gly Ile Ala Asn 
    450                 455                 460                 


Val Ala Thr Arg Leu Ser Ser Ile Gln Leu Gly Gln Ser Glu Lys Glu 
465                 470                 475                 480 


Arg Pro Glu Glu Ala Arg Glu Leu Asp Ser Ser Asp Arg Asp Ile Ser 
                485                 490                 495     


Ser Ala Thr Asp Leu Gln Pro Asp Gln Ala Glu Thr Glu Asp Thr Glu 
            500                 505                 510         


Glu Glu Leu Val Asp Gly Leu Glu Asp Cys Cys Ser Arg Asp Glu Asn 
        515                 520                 525             


Glu Glu Glu Glu Gly Asp Ser Glu Cys Ser Ser Leu Ser Ala Val Ser 
    530                 535                 540                 


Pro Ser Glu Ser Val Ala Met Ile Ser Arg Ser Cys Met Glu Ile Leu 
545                 550                 555                 560 


Thr Lys Pro Leu Ser Asn His Glu Lys Val Val Arg Pro Ala Leu Ile 
                565                 570                 575     


Tyr Ser Leu Phe Pro Asn Val Pro Pro Thr Ile Tyr Phe Gly Thr Arg 
            580                 585                 590         


Asp Glu Arg Val Glu Lys Leu Pro Trp Glu Gln Arg Lys Leu Leu Arg 
        595                 600                 605             


Trp Lys Met Ser Thr Val Thr Pro Asn Ile Val Lys Gln Thr Ile Gly 
    610                 615                 620                 


Arg Ser His Phe Lys Ile Ser Lys Arg Asn Asp Asp Trp Leu Gly Cys 
625                 630                 635                 640 


Trp Gly His His Met Lys Ser Pro Ser Phe Arg Ser Ile Arg Glu His 
                645                 650                 655     


Gln Lys Leu Asn His Phe Pro Gly Ser Phe Gln Ile Gly Arg Lys Asp 
            660                 665                 670         


Arg Leu Trp Arg Asn Leu Ser Arg Met Gln Ser Arg Phe Gly Lys Lys 
        675                 680                 685             


Glu Phe Ser Phe Phe Pro Gln Ser Phe Ile Leu Pro Gln Asp Ala Lys 
    690                 695                 700                 


Leu Leu Arg Lys Ala Trp Glu Ser Ser Ser Arg Gln Lys Trp Ile Val 
705                 710                 715                 720 


Lys Pro Pro Ala Ser Ala Arg Gly Ile Gly Ile Gln Val Ile His Lys 
                725                 730                 735     


Trp Ser Gln Leu Pro Lys Arg Arg Pro Leu Leu Val Gln Arg Tyr Leu 
            740                 745                 750         


His Lys Pro Tyr Leu Ile Ser Gly Ser Lys Phe Asp Leu Arg Ile Tyr 
        755                 760                 765             


Val Tyr Val Thr Ser Tyr Asp Pro Leu Arg Ile Tyr Leu Phe Ser Asp 
    770                 775                 780                 


Gly Leu Val Arg Phe Ala Ser Cys Lys Tyr Ser Pro Ser Met Lys Ser 
785                 790                 795                 800 


Leu Gly Asn Lys Phe Met His Leu Thr Asn Tyr Ser Val Asn Lys Lys 
                805                 810                 815     


Asn Ala Glu Tyr Gln Ala Asn Ala Asp Glu Met Ala Cys Gln Gly His 
            820                 825                 830         


Lys Trp Ala Leu Lys Ala Leu Trp Asn Tyr Leu Ser Gln Lys Gly Val 
        835                 840                 845             


Asn Ser Asp Ala Ile Trp Glu Lys Ile Lys Asp Val Val Val Lys Thr 
    850                 855                 860                 


Ile Ile Ser Ser Glu Pro Tyr Val Thr Ser Leu Leu Lys Met Tyr Val 
865                 870                 875                 880 


Arg Arg Pro Tyr Ser Cys His Glu Leu Phe Gly Phe Asp Ile Met Leu 
                885                 890                 895     


Asp Glu Asn Leu Lys Pro Trp Val Leu Glu Val Asn Ile Ser Pro Ser 
            900                 905                 910         


Leu His Ser Ser Ser Pro Leu Asp Ile Ser Ile Lys Gly Gln Met Ile 
        915                 920                 925             


Arg Asp Leu Leu Asn Leu Ala Gly Phe Val Leu Pro Asn Ala Glu Asp 
    930                 935                 940                 


Ile Ile Ser Ser Pro Ser Ser Cys Ser Ser Ser Thr Thr Ser Leu Pro 
945                 950                 955                 960 


Thr Ser Pro Gly Asp Lys Cys Arg Met Ala Pro Glu His Val Thr Ala 
                965                 970                 975     


Gln Lys Met Lys Lys Ala Tyr Tyr Leu Thr Gln Lys Ile Pro Asp Gln 
            980                 985                 990         


Asp Phe Tyr Ala Ser Val Leu Asp  Val Leu Thr Pro Asp  Asp Val Arg 
        995                 1000                 1005             


Ile Leu  Val Glu Met Glu Asp  Glu Phe Ser Arg Arg  Gly Gln Phe 
    1010                 1015                 1020             


Glu Arg  Ile Phe Pro Ser His  Ile Ser Ser Arg Tyr  Leu Arg Phe 
    1025                 1030                 1035             


Phe Glu  Gln Pro Arg Tyr Phe  Asn Ile Leu Thr Thr  Gln Trp Glu 
    1040                 1045                 1050             


Gln Lys  Tyr His Gly Asn Lys  Leu Lys Gly Val Asp  Leu Leu Arg 
    1055                 1060                 1065             


Ser Trp  Cys Tyr Lys Gly Phe  His Met Gly Val Val  Ser Asp Ser 
    1070                 1075                 1080             


Ala Pro  Val Trp Ser Leu Pro  Thr Ser Leu Leu Thr  Ile Ser Lys 
    1085                 1090                 1095             


Asp Asp  Val Ile Leu Asn Ala  Phe Ser Lys Ser Glu  Thr Ser Lys 
    1100                 1105                 1110             


Leu Gly  Lys Gln Ser Ser Cys  Glu Val Ser Leu Leu  Leu Ser Glu 
    1115                 1120                 1125             


Asp Gly  Thr Thr Pro Lys Ser  Lys Lys Thr Gln Ala  Gly Leu Ser 
    1130                 1135                 1140             


Pro Tyr  Pro Gln Lys Pro Ser  Ser Ser Lys Asp Ser  Glu Asp Thr 
    1145                 1150                 1155             


Ser Lys  Glu Pro Ser Leu Ser  Thr Gln Thr Leu Pro  Val Ile Lys 
    1160                 1165                 1170             


Cys Ser  Gly Gln Thr Ser Arg  Leu Ser Ala Ser Ser  Thr Phe Gln 
    1175                 1180                 1185             


Ser Ile  Ser Asp Ser Leu Leu  Ala Val Ser Pro 
    1190                 1195                 


<210> 4862
<211> 923
<212> PRT
<213> Homo sapiens

<400> 4862
Met Leu Arg Arg Gly Ser Gln Ala Leu Arg Arg Phe Ser Thr Gly Arg 
1               5                   10                  15      


Val Tyr Phe Lys Asn Lys Leu Lys Leu Ala Leu Ile Gly Gln Ser Leu 
            20                  25                  30          


Phe Gly Gln Glu Val Tyr Ser His Leu Arg Lys Glu Gly His Arg Val 
        35                  40                  45              


Val Gly Val Phe Thr Val Pro Asp Lys Asp Gly Lys Ala Asp Pro Leu 
    50                  55                  60                  


Ala Leu Ala Ala Glu Lys Asp Gly Thr Pro Val Phe Lys Leu Pro Lys 
65                  70                  75                  80  


Trp Arg Val Lys Gly Lys Thr Ile Lys Glu Val Ala Glu Ala Tyr Arg 
                85                  90                  95      


Ser Val Gly Ala Glu Leu Asn Val Leu Pro Phe Cys Thr Gln Phe Ile 
            100                 105                 110         


Pro Met Asp Ile Ile Asp Ser Pro Lys His Gly Ser Ile Ile Tyr His 
        115                 120                 125             


Pro Ser Ile Leu Pro Arg His Arg Gly Ala Ser Ala Ile Asn Trp Thr 
    130                 135                 140                 


Leu Ile Met Gly Asp Lys Lys Ala Gly Phe Ser Val Phe Trp Ala Asp 
145                 150                 155                 160 


Asp Gly Leu Asp Thr Gly Pro Ile Leu Leu Gln Arg Ser Cys Asp Val 
                165                 170                 175     


Glu Pro Asn Asp Thr Val Asp Ala Leu Tyr Asn Arg Phe Leu Phe Pro 
            180                 185                 190         


Glu Gly Ile Lys Ala Met Val Glu Ala Val Gln Leu Ile Ala Asp Gly 
        195                 200                 205             


Lys Ala Pro Arg Ile Pro Gln Pro Glu Glu Gly Ala Thr Tyr Glu Gly 
    210                 215                 220                 


Ile Gln Lys Lys Glu Asn Ala Glu Ile Ser Trp Asp Gln Ser Ala Glu 
225                 230                 235                 240 


Val Leu His Asn Trp Ile Arg Gly His Asp Lys Val Pro Gly Ala Trp 
                245                 250                 255     


Thr Glu Ile Asn Gly Gln Met Val Thr Phe Tyr Gly Ser Thr Leu Leu 
            260                 265                 270         


Asn Ser Ser Val Pro Pro Gly Glu Pro Leu Glu Ile Lys Gly Ala Lys 
        275                 280                 285             


Lys Pro Gly Leu Val Thr Lys Asn Gly Leu Val Leu Phe Gly Asn Asp 
    290                 295                 300                 


Gly Lys Ala Leu Thr Val Arg Asn Leu Gln Phe Glu Asp Gly Lys Met 
305                 310                 315                 320 


Ile Pro Ala Ser Gln Tyr Phe Ser Thr Gly Glu Thr Ser Val Val Glu 
                325                 330                 335     


Leu Thr Ala Glu Glu Val Lys Val Ala Glu Thr Ile Lys Val Ile Trp 
            340                 345                 350         


Ala Gly Ile Leu Ser Asn Val Pro Ile Ile Glu Asp Ser Thr Asp Phe 
        355                 360                 365             


Phe Lys Ser Gly Ala Ser Ser Met Asp Val Ala Arg Leu Val Glu Glu 
    370                 375                 380                 


Ile Arg Gln Lys Cys Gly Gly Leu Gln Leu Gln Asn Glu Asp Val Tyr 
385                 390                 395                 400 


Met Ala Thr Lys Phe Glu Gly Phe Ile Gln Lys Val Val Arg Lys Leu 
                405                 410                 415     


Arg Gly Glu Asp Gln Glu Val Glu Leu Val Val Asp Tyr Ile Ser Lys 
            420                 425                 430         


Glu Val Asn Glu Ile Met Val Lys Met Pro Tyr Gln Cys Phe Ile Asn 
        435                 440                 445             


Gly Gln Phe Thr Asp Ala Asp Asp Gly Lys Thr Tyr Asp Thr Ile Asn 
    450                 455                 460                 


Pro Thr Asp Gly Ser Thr Ile Cys Lys Val Ser Tyr Ala Ser Leu Ala 
465                 470                 475                 480 


Asp Val Asp Lys Ala Val Ala Ala Ala Lys Asp Ala Phe Glu Asn Gly 
                485                 490                 495     


Glu Trp Gly Arg Met Asn Ala Arg Glu Arg Gly Arg Leu Met Tyr Arg 
            500                 505                 510         


Leu Ala Asp Leu Leu Glu Glu Asn Gln Glu Glu Leu Ala Thr Ile Glu 
        515                 520                 525             


Ala Leu Asp Ser Gly Ala Val Tyr Thr Leu Ala Leu Lys Thr His Ile 
    530                 535                 540                 


Gly Met Ser Val Gln Thr Phe Arg Tyr Phe Ala Gly Trp Cys Asp Lys 
545                 550                 555                 560 


Ile Gln Gly Ser Thr Ile Pro Ile Asn Gln Ala Arg Pro Asn Arg Asn 
                565                 570                 575     


Leu Thr Phe Thr Lys Lys Glu Pro Leu Gly Val Cys Ala Ile Ile Ile 
            580                 585                 590         


Pro Trp Asn Tyr Pro Leu Met Met Leu Ala Trp Lys Ser Ala Ala Cys 
        595                 600                 605             


Leu Ala Ala Gly Asn Thr Leu Val Leu Lys Pro Ala Gln Val Thr Pro 
    610                 615                 620                 


Leu Thr Ala Leu Lys Phe Ala Glu Leu Ser Val Lys Ala Gly Phe Pro 
625                 630                 635                 640 


Lys Gly Val Ile Asn Ile Ile Pro Gly Ser Gly Gly Ile Ala Gly Gln 
                645                 650                 655     


Arg Leu Ser Glu His Pro Asp Ile Arg Lys Leu Gly Phe Thr Gly Ser 
            660                 665                 670         


Thr Pro Ile Gly Lys Gln Ile Met Lys Ser Cys Ala Val Ser Asn Leu 
        675                 680                 685             


Lys Lys Val Ser Leu Glu Leu Gly Gly Lys Ser Pro Leu Ile Ile Phe 
    690                 695                 700                 


Asn Asp Cys Glu Leu Asp Lys Ala Val Arg Met Gly Met Gly Ala Val 
705                 710                 715                 720 


Phe Phe Asn Lys Gly Glu Asn Cys Ile Ala Ala Gly Arg Leu Phe Val 
                725                 730                 735     


Glu Glu Ser Ile His Asp Glu Phe Val Thr Arg Val Val Glu Glu Ile 
            740                 745                 750         


Lys Lys Met Lys Ile Gly Asp Pro Leu Asp Arg Ser Thr Asp His Gly 
        755                 760                 765             


Pro Gln Asn His Lys Ala His Leu Glu Lys Leu Leu Gln Tyr Cys Glu 
    770                 775                 780                 


Thr Gly Val Lys Glu Gly Ala Thr Leu Val Tyr Gly Gly Arg Gln Val 
785                 790                 795                 800 


Gln Arg Pro Gly Phe Phe Met Glu Pro Thr Val Phe Thr Asp Val Glu 
                805                 810                 815     


Asp Tyr Met Tyr Leu Ala Lys Glu Glu Ser Phe Gly Pro Ile Met Val 
            820                 825                 830         


Ile Ser Lys Phe Gln Asn Gly Asp Ile Asp Gly Val Leu Gln Arg Ala 
        835                 840                 845             


Asn Ser Thr Glu Tyr Gly Leu Ala Ser Gly Val Phe Thr Arg Asp Ile 
    850                 855                 860                 


Asn Lys Ala Met Tyr Val Ser Glu Lys Leu Glu Ala Gly Thr Val Phe 
865                 870                 875                 880 


Ile Asn Thr Tyr Asn Lys Thr Asp Val Ala Ala Pro Phe Gly Gly Val 
                885                 890                 895     


Lys Gln Ser Gly Phe Gly Lys Asp Leu Gly Glu Glu Ala Leu Asn Glu 
            900                 905                 910         


Tyr Leu Lys Thr Lys Thr Val Thr Leu Glu Tyr 
        915                 920             


<210> 4863
<211> 440
<212> PRT
<213> Homo sapiens

<400> 4863
Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln 
1               5                   10                  15      


Pro Arg Trp Phe Leu Leu Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser 
            20                  25                  30          


Pro Glu Asp Ala Trp Lys Gly Cys Lys Gly Ser Ile Gln Met Ala Val 
        35                  40                  45              


Cys Glu Ile Gln Val His Ser Val Asp Asn Thr Arg Met Asp Leu Ile 
    50                  55                  60                  


Ile Pro Gly Glu Gln Tyr Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu 
65                  70                  75                  80  


Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr 
                85                  90                  95      


Asp Ser Arg Thr Gln Lys Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn 
            100                 105                 110         


Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val 
        115                 120                 125             


Gln Gln Val Asp Lys Thr Lys Glu Val Thr Thr Thr Gly Val Ser Asn 
    130                 135                 140                 


Ser Glu Glu Gly Ile Asp Val Gly Thr Leu Leu Lys Ser Thr Cys Asn 
145                 150                 155                 160 


Thr Phe Leu Lys Thr Leu Glu Glu Cys Met Gln Ile Ala Asn Ala Ala 
                165                 170                 175     


Phe Thr Ser Glu Leu Leu Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu 
            180                 185                 190         


Ala Met Leu Lys Ser Ser Lys Met Lys His Pro Ile Ile Pro Ile His 
        195                 200                 205             


Asn Ser Leu Glu Arg Gln Met Glu Leu Ser Thr Cys Glu Asn Gly Ser 
    210                 215                 220                 


Leu Asn Met Glu Ile Asn Gly Glu Glu Glu Ile Leu Met Lys Asn Lys 
225                 230                 235                 240 


Asn Ser Leu Tyr Leu Lys Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser 
                245                 250                 255     


Glu Glu Asn Thr Asp Asp Asn Ile Thr Val Gln Gly Glu Ile Arg Lys 
            260                 265                 270         


Glu Asp Gly Met Glu Asn Leu Lys Asn His Asp Asn Asn Leu Thr Gln 
        275                 280                 285             


Ser Gly Ser Asp Ser Ser Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly 
    290                 295                 300                 


Lys Glu Val Ile Pro Thr Phe Phe Ser Thr Met Asn Thr Ser Phe Ser 
305                 310                 315                 320 


Asp Ile Glu Leu Leu Glu Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu 
                325                 330                 335     


Ala Ser Cys Tyr Ala Val Val Pro Val Leu Asp Lys Leu Gly Pro Thr 
            340                 345                 350         


Val Phe Ala Pro Val Lys Met Asp Leu Val Gly Asn Ile Lys Lys Val 
        355                 360                 365             


Asn Gln Lys Tyr Ile Thr Asn Lys Glu Glu Phe Thr Thr Leu Gln Lys 
    370                 375                 380                 


Ile Val Leu His Glu Val Glu Ala Asp Val Ala Gln Val Arg Asn Ser 
385                 390                 395                 400 


Ala Thr Glu Ala Leu Leu Trp Leu Lys Arg Gly Leu Lys Phe Leu Lys 
                405                 410                 415     


Gly Phe Leu Thr Glu Val Lys Asn Gly Glu Lys Asp Ile Gln Thr Ala 
            420                 425                 430         


Leu Arg Asn Pro Thr Glu Asn Thr 
        435                 440 


<210> 4864
<211> 423
<212> PRT
<213> Homo sapiens

<400> 4864
Met Ala Ile Cys Gln Phe Phe Leu Gln Gly Arg Cys Arg Phe Gly Asp 
1               5                   10                  15      


Arg Cys Trp Asn Glu His Pro Gly Ala Arg Gly Ala Gly Gly Gly Arg 
            20                  25                  30          


Gln Gln Pro Gln Gln Gln Pro Ser Gly Asn Asn Arg Arg Gly Trp Asn 
        35                  40                  45              


Thr Thr Ser Gln Arg Tyr Ser Asn Val Ile Gln Pro Ser Ser Phe Ser 
    50                  55                  60                  


Lys Ser Thr Pro Trp Gly Gly Ser Arg Asp Gln Glu Lys Pro Tyr Phe 
65                  70                  75                  80  


Ser Ser Phe Asp Ser Gly Ala Ser Thr Asn Arg Lys Glu Gly Phe Gly 
                85                  90                  95      


Leu Ser Glu Asn Pro Phe Ala Ser Leu Ser Pro Asp Glu Gln Lys Asp 
            100                 105                 110         


Glu Lys Lys Leu Leu Glu Gly Ile Val Lys Asp Met Glu Val Trp Glu 
        115                 120                 125             


Ser Ser Gly Gln Trp Met Phe Ser Val Tyr Ser Pro Val Lys Lys Lys 
    130                 135                 140                 


Pro Asn Ile Ser Gly Phe Thr Asp Ile Ser Pro Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Glu Tyr His Asn Phe Leu Thr Ser Asn Asn Leu Gln Ser Tyr Leu Asn 
                165                 170                 175     


Ser Val Gln Arg Leu Ile Asn Gln Trp Arg Asn Arg Val Asn Glu Leu 
            180                 185                 190         


Lys Ser Leu Asn Ile Ser Thr Lys Val Ala Leu Leu Ser Asp Val Lys 
        195                 200                 205             


Asp Gly Val Asn Gln Ala Ala Pro Ala Phe Gly Phe Gly Ser Ser Gln 
    210                 215                 220                 


Ala Ala Thr Phe Met Ser Pro Gly Phe Pro Val Asn Asn Ser Ser Ser 
225                 230                 235                 240 


Asp Asn Ala Gln Asn Phe Ser Phe Lys Thr Asn Ser Gly Phe Ala Ala 
                245                 250                 255     


Ala Ser Ser Gly Ser Pro Ala Gly Phe Gly Ser Ser Pro Ala Phe Gly 
            260                 265                 270         


Ala Ala Ala Ser Thr Ser Ser Gly Ile Ser Thr Ser Ala Pro Ala Phe 
        275                 280                 285             


Gly Phe Gly Lys Pro Glu Val Thr Ser Ala Ala Ser Phe Ser Phe Lys 
    290                 295                 300                 


Ser Pro Ala Ala Ser Ser Phe Gly Ser Pro Gly Phe Ser Gly Leu Pro 
305                 310                 315                 320 


Ala Ser Leu Ala Thr Gly Pro Val Arg Ala Pro Val Ala Pro Ala Phe 
                325                 330                 335     


Gly Gly Gly Ser Ser Val Ala Gly Phe Gly Ser Pro Gly Ser His Ser 
            340                 345                 350         


His Thr Ala Phe Ser Lys Pro Ser Ser Asp Thr Phe Gly Asn Ser Ser 
        355                 360                 365             


Ile Ser Thr Ser Leu Ser Ala Ser Ser Ser Ile Ile Ala Thr Asp Asn 
    370                 375                 380                 


Val Leu Phe Thr Pro Arg Asp Lys Leu Thr Val Glu Glu Leu Glu Gln 
385                 390                 395                 400 


Phe Gln Ser Lys Lys Phe Thr Leu Gly Lys Ile Pro Leu Lys Pro Pro 
                405                 410                 415     


Pro Leu Glu Leu Leu Asn Val 
            420             


<210> 4865
<211> 440
<212> PRT
<213> Homo sapiens

<400> 4865
Met Met Ala Asp Glu Glu Glu Glu Val Lys Pro Ile Leu Gln Lys Leu 
1               5                   10                  15      


Gln Glu Leu Val Asp Gln Leu Tyr Ser Phe Arg Asp Cys Tyr Phe Glu 
            20                  25                  30          


Thr His Ser Val Glu Asp Ala Gly Arg Lys Gln Gln Asp Val Gln Lys 
        35                  40                  45              


Glu Met Glu Lys Thr Leu Gln Gln Met Glu Glu Val Val Gly Ser Val 
    50                  55                  60                  


Gln Gly Lys Ala Gln Val Leu Met Leu Thr Gly Lys Ala Leu Asn Val 
65                  70                  75                  80  


Thr Pro Asp Tyr Ser Pro Lys Ala Glu Glu Leu Leu Ser Lys Ala Val 
                85                  90                  95      


Lys Leu Glu Pro Glu Leu Val Glu Ala Trp Asn Gln Leu Gly Glu Val 
            100                 105                 110         


Tyr Trp Lys Lys Gly Asp Val Ala Ala Ala His Thr Cys Phe Ser Gly 
        115                 120                 125             


Ala Leu Thr His Cys Arg Asn Lys Val Ser Leu Gln Asn Leu Ser Met 
    130                 135                 140                 


Val Leu Arg Gln Leu Arg Thr Asp Thr Glu Asp Glu His Ser His His 
145                 150                 155                 160 


Val Met Asp Ser Val Arg Gln Ala Lys Leu Ala Val Gln Met Asp Val 
                165                 170                 175     


His Asp Gly Arg Ser Trp Tyr Ile Leu Gly Asn Ser Tyr Leu Ser Leu 
            180                 185                 190         


Tyr Phe Ser Thr Gly Gln Asn Pro Lys Ile Ser Gln Gln Ala Leu Ser 
        195                 200                 205             


Ala Tyr Ala Gln Ala Glu Lys Val Asp Arg Lys Ala Ser Ser Asn Pro 
    210                 215                 220                 


Asp Leu His Leu Asn Arg Ala Thr Leu His Lys Tyr Glu Glu Ser Tyr 
225                 230                 235                 240 


Gly Glu Ala Leu Glu Gly Phe Ser Arg Ala Ala Ala Leu Asp Pro Ala 
                245                 250                 255     


Trp Pro Glu Pro Arg Gln Arg Glu Gln Gln Leu Leu Glu Phe Leu Asp 
            260                 265                 270         


Arg Leu Thr Ser Leu Leu Glu Ser Lys Gly Lys Val Lys Thr Lys Lys 
        275                 280                 285             


Leu Gln Ser Met Leu Gly Ser Leu Arg Pro Ala His Leu Gly Pro Cys 
    290                 295                 300                 


Ser Asp Gly His Tyr Gln Ser Ala Ser Gly Gln Lys Val Thr Leu Glu 
305                 310                 315                 320 


Leu Lys Pro Leu Ser Thr Leu Gln Pro Gly Val Asn Ser Gly Ala Val 
                325                 330                 335     


Ile Leu Gly Lys Val Val Phe Ser Leu Thr Thr Glu Glu Lys Val Pro 
            340                 345                 350         


Phe Thr Phe Gly Leu Val Asp Ser Asp Gly Pro Cys Tyr Ala Val Met 
        355                 360                 365             


Val Tyr Asn Ile Val Gln Ser Trp Gly Val Leu Ile Gly Asp Ser Val 
    370                 375                 380                 


Ala Ile Pro Glu Pro Asn Leu Arg Leu His Arg Ile Gln His Lys Gly 
385                 390                 395                 400 


Lys Asp Tyr Ser Phe Ser Ser Val Arg Val Glu Thr Pro Leu Leu Leu 
                405                 410                 415     


Val Val Asn Gly Lys Pro Gln Gly Ser Ser Ser Gln Ala Val Ala Thr 
            420                 425                 430         


Val Ala Ser Arg Pro Gln Cys Glu 
        435                 440 


<210> 4866
<211> 446
<212> PRT
<213> Homo sapiens

<400> 4866
Met Glu Glu Thr Ile Lys Asp Pro Pro Thr Ser Ala Val Leu Leu Asp 
1               5                   10                  15      


His Cys His Phe Ser Gln Val Ile Phe Asn Ser Val Glu Lys Phe Tyr 
            20                  25                  30          


Ile Pro Gly Gly Asp Val Thr Cys His Tyr Thr Phe Thr Gln His Phe 
        35                  40                  45              


Ile Pro Arg Arg Lys Asp Trp Ile Gly Ile Phe Arg Val Gly Trp Lys 
    50                  55                  60                  


Thr Thr Arg Glu Tyr Tyr Thr Phe Met Trp Val Thr Leu Pro Ile Asp 
65                  70                  75                  80  


Leu Asn Asn Lys Ser Ala Lys Gln Gln Glu Val Gln Phe Lys Ala Tyr 
                85                  90                  95      


Tyr Leu Pro Lys Asp Asp Glu Tyr Tyr Gln Phe Cys Tyr Val Asp Glu 
            100                 105                 110         


Asp Gly Val Val Arg Gly Ala Ser Ile Pro Phe Gln Phe Arg Pro Glu 
        115                 120                 125             


Asn Glu Glu Asp Ile Leu Val Val Thr Thr Gln Gly Glu Val Glu Glu 
    130                 135                 140                 


Ile Glu Gln His Asn Lys Glu Leu Cys Lys Glu Asn Gln Glu Leu Lys 
145                 150                 155                 160 


Asp Ser Cys Ile Ser Leu Gln Lys Gln Asn Ser Asp Met Gln Ala Glu 
                165                 170                 175     


Leu Gln Lys Lys Gln Glu Glu Leu Glu Thr Leu Gln Ser Ile Asn Lys 
            180                 185                 190         


Lys Leu Glu Leu Lys Val Lys Glu Gln Lys Asp Tyr Trp Glu Thr Glu 
        195                 200                 205             


Leu Leu Gln Leu Lys Glu Gln Asn Gln Lys Met Ser Ser Glu Asn Glu 
    210                 215                 220                 


Lys Met Gly Ile Arg Val Asp Gln Leu Gln Ala Gln Leu Ser Thr Gln 
225                 230                 235                 240 


Glu Lys Glu Met Glu Lys Leu Val Gln Gly Asp Gln Asp Lys Thr Glu 
                245                 250                 255     


Gln Leu Glu Gln Leu Lys Lys Glu Asn Asp His Leu Phe Leu Ser Leu 
            260                 265                 270         


Thr Glu Gln Arg Lys Asp Gln Lys Lys Leu Glu Gln Thr Val Glu Gln 
        275                 280                 285             


Met Lys Gln Asn Glu Thr Thr Ala Met Lys Lys Gln Gln Glu Leu Met 
    290                 295                 300                 


Asp Glu Asn Phe Asp Leu Ser Lys Arg Leu Ser Glu Asn Glu Ile Ile 
305                 310                 315                 320 


Cys Asn Ala Leu Gln Arg Gln Lys Glu Arg Leu Glu Gly Glu Asn Asp 
                325                 330                 335     


Leu Leu Lys Arg Glu Asn Ser Arg Leu Leu Ser Tyr Met Gly Leu Asp 
            340                 345                 350         


Phe Asn Ser Leu Pro Tyr Gln Val Pro Thr Ser Asp Glu Gly Gly Ala 
        355                 360                 365             


Arg Gln Asn Pro Gly Leu Ala Tyr Gly Asn Pro Tyr Ser Gly Ile Gln 
    370                 375                 380                 


Glu Ser Ser Ser Pro Ser Pro Leu Ser Ile Lys Lys Cys Pro Ile Cys 
385                 390                 395                 400 


Lys Ala Asp Asp Ile Cys Asp His Thr Leu Glu Gln Gln Gln Met Gln 
                405                 410                 415     


Pro Leu Cys Phe Asn Cys Pro Ile Cys Asp Lys Ile Phe Pro Ala Thr 
            420                 425                 430         


Glu Lys Gln Ile Phe Glu Asp His Val Phe Cys His Ser Leu 
        435                 440                 445     


<210> 4867
<211> 442
<212> PRT
<213> Homo sapiens

<400> 4867
Met Ala Leu Pro Gly Ala Arg Ala Arg Gly Trp Ala Ala Ala Ala Arg 
1               5                   10                  15      


Ala Ala Gln Arg Arg Arg Arg Val Glu Asn Ala Gly Gly Ser Pro Ser 
            20                  25                  30          


Pro Glu Pro Ala Gly Arg Arg Ala Ala Leu Tyr Val His Trp Pro Tyr 
        35                  40                  45              


Cys Glu Lys Arg Cys Ser Tyr Cys Asn Phe Asn Lys Tyr Ile Pro Arg 
    50                  55                  60                  


Arg Leu Glu Glu Ala Ala Met Gln Lys Cys Leu Val Thr Glu Ala Gln 
65                  70                  75                  80  


Thr Leu Leu Arg Leu Ser Gly Val Gln Arg Val Glu Ser Val Phe Phe 
                85                  90                  95      


Gly Gly Gly Thr Pro Ser Leu Ala Ser Pro His Thr Val Ala Ala Val 
            100                 105                 110         


Leu Glu Ala Val Ala Gln Ala Ala His Leu Pro Ala Asp Leu Glu Val 
        115                 120                 125             


Thr Leu Glu Ala Asn Pro Thr Ser Ala Pro Gly Ser Arg Leu Ala Glu 
    130                 135                 140                 


Phe Gly Ala Ala Gly Val Asn Arg Leu Ser Ile Gly Leu Gln Ser Leu 
145                 150                 155                 160 


Asp Asp Thr Glu Leu Arg Leu Leu Gly Arg Thr His Ser Ala Cys Asp 
                165                 170                 175     


Ala Leu Arg Thr Leu Ala Glu Ala Arg Arg Leu Phe Pro Gly Arg Val 
            180                 185                 190         


Ser Val Asp Leu Met Leu Gly Leu Pro Ala Gln Gln Val Gly Pro Trp 
        195                 200                 205             


Leu Gly Gln Leu Gln Glu Leu Leu His His Cys Asp Asp His Leu Ser 
    210                 215                 220                 


Leu Tyr Gln Leu Ser Leu Glu Arg Gly Thr Ala Leu Phe Ala Gln Val 
225                 230                 235                 240 


Gln Arg Gly Ala Leu Pro Ala Pro Asp Pro Glu Leu Ala Ala Glu Met 
                245                 250                 255     


Tyr Gln Arg Gly Arg Ala Val Leu Arg Glu Ala Gly Phe His Gln Tyr 
            260                 265                 270         


Glu Val Ser Asn Phe Ala Arg Asn Gly Ala Leu Ser Thr His Asn Trp 
        275                 280                 285             


Thr Tyr Trp Gln Cys Gly Gln Tyr Leu Gly Val Gly Pro Gly Ala His 
    290                 295                 300                 


Gly Arg Phe Met Pro Gln Gly Ala Gly Gly His Thr Arg Glu Ala Arg 
305                 310                 315                 320 


Ile Gln Thr Leu Glu Pro Asp Asn Trp Met Lys Glu Val Met Leu Phe 
                325                 330                 335     


Gly His Gly Thr Arg Lys Arg Val Pro Leu Gly Arg Leu Glu Leu Leu 
            340                 345                 350         


Glu Glu Val Leu Ala Leu Gly Leu Arg Thr Asp Val Gly Ile Thr His 
        355                 360                 365             


Gln His Trp Gln Gln Phe Glu Pro Gln Leu Thr Leu Trp Asp Val Phe 
    370                 375                 380                 


Gly Ala Asn Lys Glu Val Gln Glu Leu Leu Glu Arg Gly Leu Leu Gln 
385                 390                 395                 400 


Leu Asp His Arg Gly Leu Arg Cys Ser Trp Glu Gly Leu Ala Val Leu 
                405                 410                 415     


Asp Ser Leu Leu Leu Thr Leu Leu Pro Gln Leu Gln Glu Ala Trp Gln 
            420                 425                 430         


Gln Arg Thr Pro Ser Pro Val Pro Gly Gly 
        435                 440         


<210> 4868
<211> 425
<212> PRT
<213> Homo sapiens

<400> 4868
Met Asp Lys Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe 
1               5                   10                  15      


Arg Gln Ala Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln 
            20                  25                  30          


Lys Thr Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu 
        35                  40                  45              


Ser Leu Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu 
    50                  55                  60                  


Val Asn Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu 
65                  70                  75                  80  


Asp Ser Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp 
                85                  90                  95      


Lys Val Ile Ser Gly Ile Ala Arg Glu Lys Leu Pro Lys Val Arg Arg 
            100                 105                 110         


Gln Glu Val Ser Ser Pro Arg Lys Glu Thr Ser Ala Arg Ser Leu Gly 
        115                 120                 125             


Ser Pro Leu Leu His Glu Arg Gly Asn Ile Glu Lys Thr Phe Trp Asp 
    130                 135                 140                 


Leu Lys Glu Glu Phe His Lys Ile Cys Met Leu Ala Lys Ala Gln Lys 
145                 150                 155                 160 


Asp His Leu Ser Lys Leu Asn Ile Pro Asp Thr Ala Thr Glu Thr Gln 
                165                 170                 175     


Cys Ser Val Pro Ile Gln Cys Thr Asp Lys Thr Asp Lys Gln Glu Ala 
            180                 185                 190         


Leu Phe Lys Pro Gln Ala Lys Asp Asp Ile Asn Arg Gly Ala Pro Ser 
        195                 200                 205             


Ile Thr Ser Val Thr Pro Arg Gly Leu Cys Arg Asp Glu Glu Asp Thr 
    210                 215                 220                 


Ser Phe Glu Ser Leu Ser Lys Phe Asn Val Lys Phe Pro Pro Met Asp 
225                 230                 235                 240 


Asn Asp Ser Thr Phe Leu His Ser Thr Pro Glu Arg Pro Gly Ile Leu 
                245                 250                 255     


Ser Pro Ala Thr Ser Glu Ala Val Cys Gln Glu Lys Phe Asn Met Glu 
            260                 265                 270         


Phe Arg Asp Asn Pro Gly Asn Phe Val Lys Thr Glu Glu Thr Leu Phe 
        275                 280                 285             


Glu Ile Gln Gly Ile Asp Pro Ile Ala Ser Ala Ile Gln Asn Leu Lys 
    290                 295                 300                 


Thr Thr Asp Lys Thr Lys Pro Ser Asn Leu Val Asn Thr Cys Ile Arg 
305                 310                 315                 320 


Thr Thr Leu Asp Arg Ala Ala Cys Leu Pro Pro Gly Asp His Asn Ala 
                325                 330                 335     


Leu Tyr Val Asn Ser Phe Pro Leu Leu Asp Pro Ser Asp Ala Pro Phe 
            340                 345                 350         


Pro Ser Leu Asp Ser Pro Gly Lys Ala Ile Arg Gly Pro Gln Gln Pro 
        355                 360                 365             


Ile Trp Lys Pro Phe Pro Asn Gln Asp Ser Asp Ser Val Val Leu Ser 
    370                 375                 380                 


Gly Thr Asp Ser Glu Leu His Ile Pro Arg Val Cys Glu Phe Cys Gln 
385                 390                 395                 400 


Ala Val Phe Pro Pro Ser Ile Thr Ser Arg Gly Asp Phe Leu Arg His 
                405                 410                 415     


Leu Asn Ser His Phe Asn Gly Glu Thr 
            420                 425 


<210> 4869
<211> 684
<212> PRT
<213> Homo sapiens

<400> 4869
Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys 
1               5                   10                  15      


Lys Leu Asn Gly Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met 
            20                  25                  30          


Ile Thr Asp Ile His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr 
        35                  40                  45              


Val Lys Lys Glu His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr 
    50                  55                  60                  


Asp Gly Glu His Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu 
65                  70                  75                  80  


His Leu Asn Pro Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser 
                85                  90                  95      


Ser Gln Ser Ser Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser 
            100                 105                 110         


Gln Glu Ser Met Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln 
        115                 120                 125             


Val Leu Pro Gly Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu 
    130                 135                 140                 


Thr Gln Thr Val Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly 
145                 150                 155                 160 


Gly Glu Lys Arg Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg 
                165                 170                 175     


Glu Phe Thr Leu Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile 
            180                 185                 190         


Tyr Cys Ser Arg Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu 
        195                 200                 205             


Gly Ile Leu Pro Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr 
    210                 215                 220                 


Asp Ala Gln Arg Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro 
225                 230                 235                 240 


Gln Asn Gly Ser Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys 
                245                 250                 255     


Glu Thr Gly Ser Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys 
            260                 265                 270         


Gln Gly Leu Phe Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys 
        275                 280                 285             


Ile Gln Cys Leu Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val 
    290                 295                 300                 


Met His Ser His Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe 
305                 310                 315                 320 


Glu Ser Ala Lys Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu 
                325                 330                 335     


Gly Thr Pro Glu Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys 
            340                 345                 350         


Glu Lys Phe Ser Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp 
        355                 360                 365             


Ala Pro Ser Gly Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln 
    370                 375                 380                 


Glu Gly Asp His Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr 
385                 390                 395                 400 


Tyr Leu Tyr Met Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr 
                405                 410                 415     


Ser Ala Val Ser Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Ser Lys 
            420                 425                 430         


Ser Ile Ser Arg Gln Ser Glu Lys Ala His Ser Ser Gly Lys Leu Gln 
        435                 440                 445             


Lys Thr Val Ser Tyr Pro Asp Val Ser Leu Glu Glu Gln Glu Lys Met 
    450                 455                 460                 


Asp Leu Lys Thr Ser Arg Glu Leu Cys Ser Arg Leu Asp Ala Ser Ile 
465                 470                 475                 480 


Ser Asn Asn Ser Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr Cys Asn 
                485                 490                 495     


Leu Val Arg Asp Ile Asn Lys Val Gly Ile Gly Leu Val Ala Ala Ala 
            500                 505                 510         


Ser Ser Pro Leu Leu Val Lys Asp Val Ile Cys Glu Asp Asp Lys Gly 
        515                 520                 525             


Lys Ile Met Glu Glu Val Met Arg Thr Tyr Leu Lys Gln Gln Glu Lys 
    530                 535                 540                 


Leu Asn Leu Ile Leu Gln Lys Lys Gln Gln Leu Gln Met Glu Val Lys 
545                 550                 555                 560 


Met Leu Ser Ser Ser Lys Ser Met Lys Glu Leu Thr Glu Glu Gln Gln 
                565                 570                 575     


Asn Leu Gln Lys Glu Leu Glu Ser Leu Gln Asn Glu His Ala Gln Arg 
            580                 585                 590         


Met Glu Glu Phe Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys Leu Glu 
        595                 600                 605             


Gln Ile Met Lys Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu Lys Asp 
    610                 615                 620                 


Lys Glu Ala Glu Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln Arg Leu 
625                 630                 635                 640 


Asp His Ala Glu Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu Arg Gln 
                645                 650                 655     


Glu Arg Glu Ala Arg Gln Lys Leu Glu Met Met Ile Lys Glu Leu Lys 
            660                 665                 670         


Leu Gln Ile Leu Lys Ser Ser Lys Thr Ala Lys Glu 
        675                 680                 


<210> 4870
<211> 359
<212> PRT
<213> Homo sapiens

<400> 4870
Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
1               5                   10                  15      


Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
            20                  25                  30          


Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
        35                  40                  45              


Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
    50                  55                  60                  


Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
65                  70                  75                  80  


Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Val Trp 
                85                  90                  95      


Val Pro Lys Gln Lys Pro Leu Asp Pro Val Leu Glu Ser Val Thr Leu 
            100                 105                 110         


Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
        115                 120                 125             


Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
    130                 135                 140                 


Gln Tyr Tyr Gln Ala Leu Ser Ser Ser Ser Ile Met Asn Lys Glu Gly 
145                 150                 155                 160 


Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                165                 170                 175     


Glu Pro Asn Ser Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
            180                 185                 190         


Asn Asp Pro Lys Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
        195                 200                 205             


Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ala Leu Lys Glu Asn Ser 
    210                 215                 220                 


Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
225                 230                 235                 240 


Ala Tyr Ala Leu Ala Glu Met Leu Lys Glu Asn Lys Val Leu Lys Thr 
                245                 250                 255     


Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Arg Leu 
            260                 265                 270         


Val Glu Ala Leu Pro Tyr Asn Thr Ser Leu Val Glu Met Lys Ile Asp 
        275                 280                 285             


Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Ser 
    290                 295                 300                 


Met Leu Glu Lys Asn Ala Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
305                 310                 315                 320 


Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                325                 330                 335     


Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
            340                 345                 350         


Pro Lys Cys Arg Ser Gly Val 
        355                 


<210> 4871
<211> 646
<212> PRT
<213> Homo sapiens

<400> 4871
Met Glu Glu Arg Gly Ser Pro Asp Gly Asp Leu Ala Arg Ser Leu Glu 
1               5                   10                  15      


Gln Gly Pro Glu Gly Pro Glu Thr Pro Ile Gln Val Val Leu Arg Val 
            20                  25                  30          


Arg Pro Met Ser Ala Ala Glu Leu Arg Arg Gly Gln Gln Ser Val Leu 
        35                  40                  45              


His Cys Ser Gly Thr Arg Thr Leu Gln Gly Gly Pro Glu Val Ala Phe 
    50                  55                  60                  


Arg Phe Gly Ala Val Leu Asp Ala Ala Arg Thr Gln Glu Asp Val Phe 
65                  70                  75                  80  


Arg Ala Cys Gly Val Arg Arg Leu Gly Glu Leu Ala Leu Arg Gly Phe 
                85                  90                  95      


Ser Cys Thr Val Phe Thr Phe Gly Gln Thr Gly Ser Gly Lys Thr Tyr 
            100                 105                 110         


Thr Leu Thr Gly Pro Pro Pro Gln Gly Glu Gly Val Pro Val Pro Pro 
        115                 120                 125             


Ser Leu Ala Gly Ile Met Gln Arg Thr Phe Ala Trp Leu Leu Asp Arg 
    130                 135                 140                 


Val Gln His Leu Gly Ala Pro Val Thr Leu Arg Ala Ser Tyr Leu Glu 
145                 150                 155                 160 


Ile Tyr Asn Glu Gln Val Arg Asp Leu Leu Ser Leu Gly Ser Pro Arg 
                165                 170                 175     


Pro Leu Pro Val Arg Trp Asn Lys Thr Arg Gly Phe Tyr Val Glu Gln 
            180                 185                 190         


Leu Arg Val Val Glu Phe Gly Ser Leu Glu Ala Leu Met Glu Leu Leu 
        195                 200                 205             


Gln Thr Gly Leu Ser Arg Arg Arg Asn Ser Ala His Thr Leu Asn Gln 
    210                 215                 220                 


Ala Ser Ser Arg Ser His Ala Leu Leu Thr Leu Tyr Ile Ser Arg Gln 
225                 230                 235                 240 


Thr Ala Gln Gln Met Pro Ser Val Asp Pro Gly Glu Pro Pro Val Gly 
                245                 250                 255     


Gly Lys Leu Cys Phe Val Asp Leu Ala Gly Ser Glu Lys Val Ala Ala 
            260                 265                 270         


Thr Gly Ser Arg Gly Glu Leu Met Leu Glu Ala Asn Ser Ile Asn Arg 
        275                 280                 285             


Ser Leu Leu Ala Leu Gly His Cys Ile Ser Leu Leu Leu Asp Pro Gln 
    290                 295                 300                 


Arg Lys Gln Ser His Ile Pro Phe Arg Asp Ser Lys Leu Thr Lys Leu 
305                 310                 315                 320 


Leu Ala Asp Ser Leu Gly Gly Arg Gly Val Thr Leu Met Val Ala Cys 
                325                 330                 335     


Val Ser Pro Ser Ala Gln Cys Leu Pro Glu Thr Leu Ser Thr Leu Arg 
            340                 345                 350         


Tyr Ala Ser Arg Ala Gln Arg Val Thr Thr Arg Pro Gln Ala Pro Lys 
        355                 360                 365             


Ser Pro Val Ala Lys Gln Pro Gln Arg Leu Glu Thr Glu Met Leu Gln 
    370                 375                 380                 


Leu Gln Glu Glu Asn Arg Arg Leu Gln Phe Gln Leu Asp Gln Met Asp 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Leu Ser Gly Ala Arg Val Ala Trp Ala Gln Arg 
                405                 410                 415     


Asn Leu Tyr Gly Met Leu Gln Glu Phe Met Leu Glu Asn Glu Arg Leu 
            420                 425                 430         


Arg Lys Glu Lys Ser Gln Leu Gln Asn Ser Arg Asp Leu Ala Gln Asn 
        435                 440                 445             


Glu Gln Arg Ile Leu Ala Gln Gln Val His Ala Leu Glu Arg Arg Leu 
    450                 455                 460                 


Leu Ser Ala Cys Tyr His His Gln Gln Gly Pro Gly Leu Thr Pro Pro 
465                 470                 475                 480 


Cys Pro Cys Leu Met Ala Pro Ala Pro Pro Cys His Ala Leu Pro Pro 
                485                 490                 495     


Leu Tyr Ser Cys Pro Cys Cys His Ile Cys Pro Leu Cys Arg Val Pro 
            500                 505                 510         


Leu Ala His Trp Ala Cys Leu Pro Gly Glu His His Leu Pro Gln Val 
        515                 520                 525             


Leu Asp Pro Glu Ala Ser Gly Gly Arg Pro Pro Ser Ala Arg Pro Pro 
    530                 535                 540                 


Pro Trp Ala Pro Pro Cys Ser Pro Gly Ser Ala Lys Cys Pro Arg Glu 
545                 550                 555                 560 


Arg Ser His Ser Asp Trp Thr Gln Thr Arg Val Leu Ala Glu Met Leu 
                565                 570                 575     


Thr Glu Glu Glu Val Val Pro Ser Ala Pro Pro Leu Pro Val Arg Pro 
            580                 585                 590         


Pro Lys Thr Ser Pro Gly Leu Arg Gly Gly Ala Gly Val Pro Asn Leu 
        595                 600                 605             


Ala Gln Arg Leu Glu Ala Leu Arg Asp Gln Ile Gly Ser Ser Leu Arg 
    610                 615                 620                 


Arg Gly Arg Ser Gln Pro Pro Cys Ser Glu Gly Ala Arg Ser Pro Gly 
625                 630                 635                 640 


Gln Val Leu Pro Pro His 
                645     


<210> 4872
<211> 153
<212> PRT
<213> Homo sapiens

<400> 4872
Met Ala Arg Asn Thr Leu Ser Ser Arg Phe Arg Arg Val Asp Ile Asp 
1               5                   10                  15      


Glu Phe Asp Glu Asn Lys Phe Val Asp Glu Gln Glu Glu Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Glu Pro Gly Pro Asp Pro Ser Glu Val Asp Gly Leu Leu 
        35                  40                  45              


Arg Gln Gly Asp Met Leu Arg Ala Phe His Ala Ala Leu Arg Asn Ser 
    50                  55                  60                  


Pro Val Asn Thr Lys Asn Gln Ala Val Lys Glu Arg Ala Gln Gly Val 
65                  70                  75                  80  


Val Leu Lys Val Leu Thr Asn Phe Lys Ser Ser Glu Ile Glu Gln Ala 
                85                  90                  95      


Val Gln Ser Leu Asp Arg Asn Gly Val Asp Leu Leu Met Lys Tyr Ile 
            100                 105                 110         


Tyr Lys Gly Phe Glu Lys Pro Thr Glu Asn Ser Ser Ala Val Leu Leu 
        115                 120                 125             


Gln Trp His Glu Lys Ala Leu Ala Val Gly Gly Leu Gly Ser Ile Ile 
    130                 135                 140                 


Arg Val Leu Thr Ala Arg Lys Thr Val 
145                 150             


<210> 4873
<211> 1105
<212> PRT
<213> Homo sapiens

<400> 4873
Met Ala Ala Thr Ala Ser Ala Gly Val Pro Ala Thr Val Ser Glu Lys 
1               5                   10                  15      


Gln Glu Phe Tyr Gln Leu Leu Lys Asn Leu Ile Asn Pro Ser Cys Met 
            20                  25                  30          


Val Arg Arg Gln Ala Glu Glu Ile Tyr Glu Asn Ile Pro Gly Leu Cys 
        35                  40                  45              


Lys Thr Thr Phe Leu Leu Asp Ala Val Arg Asn Arg Arg Ala Gly Tyr 
    50                  55                  60                  


Glu Val Arg Gln Met Ala Ala Ala Leu Leu Arg Arg Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Phe Glu Glu Val Tyr Pro Asn Leu Pro Ala Asp Val Gln Arg Asp 
                85                  90                  95      


Val Lys Ile Glu Leu Ile Leu Ala Val Lys Leu Glu Thr His Ala Ser 
            100                 105                 110         


Met Arg Lys Lys Leu Cys Asp Ile Phe Ala Val Leu Ala Arg Asn Leu 
        115                 120                 125             


Ile Asp Glu Asp Gly Thr Asn His Trp Pro Glu Gly Leu Lys Phe Leu 
    130                 135                 140                 


Ile Asp Ser Ile Tyr Ser Lys Asn Val Val Leu Trp Glu Val Ala Leu 
145                 150                 155                 160 


His Val Phe Trp His Phe Pro Gly Ile Phe Gly Thr Gln Glu Arg His 
                165                 170                 175     


Asp Leu Asp Ile Ile Lys Arg Leu Leu Asp Gln Cys Ile Gln Asp Gln 
            180                 185                 190         


Glu His Pro Ala Ile Arg Thr Leu Ser Ala Arg Ala Ala Ala Ala Phe 
        195                 200                 205             


Val Leu Ala Asn Glu Asn Asn Ile Ala Leu Phe Lys Asp Phe Ala Asp 
    210                 215                 220                 


Leu Leu Pro Gly Ile Leu Gln Ala Val Asn Asp Ser Cys Tyr Gln Asp 
225                 230                 235                 240 


Asp Asp Ser Val Leu Glu Ser Leu Val Glu Ile Ala Asp Thr Val Pro 
                245                 250                 255     


Lys Tyr Leu Gly Pro Tyr Leu Glu Asp Thr Leu Gln Leu Ser Leu Lys 
            260                 265                 270         


Leu Cys Gly Asp Ser Arg Leu Ser Asn Leu Gln Arg Gln Leu Ala Leu 
        275                 280                 285             


Glu Val Ile Val Thr Leu Ser Glu Thr Ala Thr Pro Met Leu Lys Lys 
    290                 295                 300                 


His Thr Asn Ile Ile Ala Gln Ala Val Pro His Ile Leu Ala Met Met 
305                 310                 315                 320 


Val Asp Leu Gln Asp Asp Glu Asp Trp Val Asn Ala Asp Glu Met Glu 
                325                 330                 335     


Glu Asp Asp Phe Asp Ser Asn Ala Val Ala Ala Glu Ser Ala Leu Asp 
            340                 345                 350         


Arg Leu Ala Cys Gly Leu Gly Gly Lys Val Val Leu Pro Met Thr Lys 
        355                 360                 365             


Glu His Ile Met Gln Met Leu Gln Ser Pro Asp Trp Lys Tyr Arg His 
    370                 375                 380                 


Ala Gly Leu Met Ala Leu Ser Ala Ile Gly Glu Gly Cys His Gln Gln 
385                 390                 395                 400 


Met Glu Ser Ile Leu Asp Glu Thr Val Asn Ser Val Leu Leu Phe Leu 
                405                 410                 415     


Gln Asp Pro His Pro Arg Val Arg Ala Ala Ala Cys Thr Thr Leu Gly 
            420                 425                 430         


Gln Met Ala Thr Asp Phe Ala Pro Asn Phe Gln Lys Lys Phe His Glu 
        435                 440                 445             


Thr Val Ile Ala Ala Leu Leu Arg Thr Met Glu Asn Gln Gly Asn Gln 
    450                 455                 460                 


Arg Val Gln Ser His Ala Ala Ser Ala Leu Ile Ile Phe Ile Glu Asp 
465                 470                 475                 480 


Cys Pro Lys Ser Leu Leu Val Leu Tyr Val Asp Ser Met Val Lys Asn 
                485                 490                 495     


Leu His Ser Val Leu Val Ile Lys Leu Gln Glu Leu Ile Arg Asn Gly 
            500                 505                 510         


Thr Lys Leu Ala Leu Glu Gln Leu Val Thr Thr Ile Ala Ser Val Ala 
        515                 520                 525             


Asp Thr Ile Glu Glu Lys Phe Val Pro Tyr Tyr Asp Ile Phe Met Pro 
    530                 535                 540                 


Ser Leu Lys His Ile Val Glu Leu Ala Val Gln Lys Glu Leu Lys Leu 
545                 550                 555                 560 


Leu Arg Gly Lys Thr Ile Glu Cys Ile Ser His Ile Gly Leu Ala Val 
                565                 570                 575     


Gly Lys Glu Lys Phe Met Gln Asp Ala Ser Asn Val Met Gln Leu Leu 
            580                 585                 590         


Leu Lys Thr Gln Ser Asp Leu Asn Asn Met Glu Asp Asp Asp Pro Gln 
        595                 600                 605             


Thr Ser Tyr Met Val Ser Ala Trp Ala Arg Met Cys Lys Ile Leu Gly 
    610                 615                 620                 


Lys Asp Phe Gln Gln Tyr Leu Pro Leu Val Ile Glu Pro Leu Ile Lys 
625                 630                 635                 640 


Thr Ala Ser Ala Lys Pro Asp Val Ala Leu Leu Asp Thr Gln Asp Val 
                645                 650                 655     


Glu Asn Met Ser Asp Asp Asp Gly Trp Gln Phe Val Asn Leu Gly Asp 
            660                 665                 670         


Gln Gln Ser Phe Gly Ile Lys Thr Ser Gly Leu Glu Ala Lys Ala Thr 
        675                 680                 685             


Ala Cys Gln Met Leu Val Tyr Tyr Ala Lys Glu Leu Arg Glu Gly Phe 
    690                 695                 700                 


Val Glu Tyr Thr Glu Gln Val Val Lys Leu Met Val Pro Leu Leu Lys 
705                 710                 715                 720 


Phe Tyr Phe His Asp Asn Val Arg Val Ala Ala Ala Glu Ser Met Pro 
                725                 730                 735     


Phe Leu Leu Glu Cys Ala Arg Ile Arg Gly Pro Glu Tyr Leu Ala Gln 
            740                 745                 750         


Met Trp Gln Phe Ile Cys Asp Pro Leu Ile Lys Ala Ile Gly Thr Glu 
        755                 760                 765             


Pro Asp Thr Asp Val Leu Ser Glu Ile Met Asn Ser Phe Ala Lys Ser 
    770                 775                 780                 


Ile Glu Val Met Gly Asp Gly Cys Leu Asn Asp Glu His Leu Glu Glu 
785                 790                 795                 800 


Leu Gly Gly Ile Leu Lys Ala Lys Leu Glu Gly His Phe Lys Asn Gln 
                805                 810                 815     


Glu Leu Arg Gln Val Lys Arg Gln Glu Glu Asn Tyr Asp Gln Gln Val 
            820                 825                 830         


Glu Met Ser Leu Gln Asp Glu Asp Glu Cys Asp Val Tyr Ile Leu Thr 
        835                 840                 845             


Lys Val Ser Asp Ile Leu His Ser Leu Phe Ser Thr Tyr Lys Glu Lys 
    850                 855                 860                 


Ile Leu Pro Trp Phe Glu Gln Leu Leu Pro Leu Ile Val Asn Leu Ile 
865                 870                 875                 880 


Cys Ser Ser Arg Pro Trp Pro Asp Arg Gln Trp Gly Leu Cys Ile Phe 
                885                 890                 895     


Asp Asp Ile Ile Glu His Cys Ser Pro Thr Ser Phe Lys Tyr Val Glu 
            900                 905                 910         


Tyr Phe Arg Trp Pro Met Leu Leu Asn Met Arg Asp Asn Asn Pro Glu 
        915                 920                 925             


Val Arg Gln Ala Ala Ala Tyr Gly Leu Gly Val Met Ala Gln Phe Gly 
    930                 935                 940                 


Gly Asp Asp Tyr Arg Ser Leu Cys Ser Glu Ala Val Pro Leu Leu Val 
945                 950                 955                 960 


Lys Val Ile Lys Cys Ala Asn Ser Lys Thr Lys Lys Asn Val Ile Ala 
                965                 970                 975     


Thr Glu Asn Cys Ile Ser Ala Ile Gly Lys Ile Leu Lys Phe Lys Pro 
            980                 985                 990         


Asn Cys Val Asn Val Asp Glu Val  Leu Pro His Trp Leu  Ser Trp Leu 
        995                 1000                 1005             


Pro Leu  His Glu Asp Lys Glu  Glu Ala Ile Gln Thr  Leu Ser Phe 
    1010                 1015                 1020             


Leu Cys  Asp Leu Ile Glu Ser  Asn His Pro Val Val  Ile Gly Pro 
    1025                 1030                 1035             


Asn Asn  Ser Asn Leu Pro Lys  Ile Ile Ser Ile Ile  Ala Glu Gly 
    1040                 1045                 1050             


Lys Ile  Asn Glu Thr Ile Asn  Tyr Glu Asp Pro Cys  Ala Lys Arg 
    1055                 1060                 1065             


Leu Ala  Asn Val Val Arg Gln  Val Gln Thr Ser Glu  Asp Leu Trp 
    1070                 1075                 1080             


Leu Glu  Cys Val Ser Gln Leu  Asp Asp Glu Gln Gln  Glu Ala Leu 
    1085                 1090                 1095             


Gln Glu  Leu Leu Asn Phe Ala  
    1100                 1105 


<210> 4874
<211> 637
<212> PRT
<213> Homo sapiens

<400> 4874
Met Glu Val Thr Gly Phe Gly Val Thr Arg Pro Gly Lys Val Pro Gln 
1               5                   10                  15      


Ala Arg Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly 
            20                  25                  30          


His Arg Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser 
        35                  40                  45              


Gln Gly Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser 
    50                  55                  60                  


Leu Ser Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly 
65                  70                  75                  80  


Leu Val His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile 
                85                  90                  95      


Glu Leu Gly Leu Ser Glu Ala Gln Val Met Leu Ala Leu Ala Ser His 
            100                 105                 110         


Leu Ser Thr Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg 
        115                 120                 125             


Arg Leu Cys Gln Glu Asn Gln Trp Leu Arg Asp Glu Leu Ala Gly Thr 
    130                 135                 140                 


Gln Gln Arg Leu Gln Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu 
145                 150                 155                 160 


Glu Lys Lys His Leu Glu Phe Leu Gly Gln Leu Arg Gln Tyr Asp Glu 
                165                 170                 175     


Asp Gly His Thr Ser Glu Glu Lys Glu Gly Asp Ala Thr Lys Asp Ser 
            180                 185                 190         


Leu Asp Asp Leu Phe Pro Asn Glu Glu Glu Glu Asp Pro Ser Asn Gly 
        195                 200                 205             


Leu Ser Arg Gly Gln Gly Ala Thr Ala Ala Gln Gln Gly Gly Tyr Glu 
    210                 215                 220                 


Ile Pro Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala 
225                 230                 235                 240 


Ala Gln Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu 
                245                 250                 255     


Glu Asp Leu Glu Arg Thr Ser Gly Arg Gly His Pro Asp Val Ala Thr 
            260                 265                 270         


Met Leu Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys 
        275                 280                 285             


Glu Ala Ala His Leu Leu Asn Asp Ala Leu Ser Ile Arg Glu Ser Thr 
    290                 295                 300                 


Leu Gly Pro Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu Ala 
305                 310                 315                 320 


Val Leu Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu Cys 
                325                 330                 335     


Gln Arg Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Thr Asn His Pro 
            340                 345                 350         


Asp Val Ala Lys Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn Gln 
        355                 360                 365             


Gly Lys Tyr Glu Ala Val Glu Arg Tyr Tyr Gln Arg Ala Leu Ala Ile 
    370                 375                 380                 


Tyr Glu Gly Gln Leu Gly Pro Asp Asn Pro Asn Val Ala Arg Thr Lys 
385                 390                 395                 400 


Asn Asn Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Tyr Ala Glu Ala 
                405                 410                 415     


Glu Thr Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Val Gln Glu Phe 
            420                 425                 430         


Gly Ser Val Asp Asp Asp His Lys Pro Ile Trp Met His Ala Glu Glu 
        435                 440                 445             


Arg Glu Glu Met Ser Lys Ser Arg His His Glu Gly Gly Thr Pro Tyr 
    450                 455                 460                 


Ala Glu Tyr Gly Gly Trp Tyr Lys Ala Cys Lys Val Ser Ser Pro Thr 
465                 470                 475                 480 


Val Asn Thr Thr Leu Arg Asn Leu Gly Ala Leu Tyr Arg Arg Gln Gly 
                485                 490                 495     


Lys Leu Glu Ala Ala Glu Thr Leu Glu Glu Cys Ala Leu Arg Ser Arg 
            500                 505                 510         


Arg Gln Gly Thr Asp Pro Ile Ser Gln Thr Lys Val Ala Glu Leu Leu 
        515                 520                 525             


Gly Glu Ser Asp Gly Arg Arg Thr Ser Gln Glu Gly Pro Gly Asp Ser 
    530                 535                 540                 


Val Lys Phe Glu Gly Gly Glu Asp Ala Ser Val Ala Val Glu Trp Ser 
545                 550                 555                 560 


Gly Asp Gly Ser Gly Thr Leu Gln Arg Ser Gly Ser Leu Gly Lys Ile 
                565                 570                 575     


Arg Asp Val Leu Arg Arg Ser Ser Glu Leu Leu Val Arg Lys Leu Gln 
            580                 585                 590         


Gly Thr Glu Pro Arg Pro Ser Ser Ser Asn Met Lys Arg Ala Ala Ser 
        595                 600                 605             


Leu Asn Tyr Leu Asn Gln Pro Ser Ala Ala Pro Leu Gln Val Ser Arg 
    610                 615                 620                 


Gly Leu Ser Ala Ser Thr Met Asp Leu Ser Ser Ser Ser 
625                 630                 635         


<210> 4875
<211> 1321
<212> PRT
<213> Homo sapiens

<400> 4875
Met Gln Cys Leu Ala Ala Ala Leu Lys Asp Glu Thr Asn Met Ser Gly 
1               5                   10                  15      


Gly Gly Glu Gln Ala Asp Ile Leu Pro Ala Asn Tyr Val Val Lys Asp 
            20                  25                  30          


Arg Trp Lys Val Leu Lys Lys Ile Gly Gly Gly Gly Phe Gly Glu Ile 
        35                  40                  45              


Tyr Glu Ala Met Asp Leu Leu Thr Arg Glu Asn Val Ala Leu Lys Val 
    50                  55                  60                  


Glu Ser Ala Gln Gln Pro Lys Gln Val Leu Lys Met Glu Val Ala Val 
65                  70                  75                  80  


Leu Lys Lys Leu Gln Gly Lys Asp His Val Cys Arg Phe Ile Gly Cys 
                85                  90                  95      


Gly Arg Asn Glu Lys Phe Asn Tyr Val Val Met Gln Leu Gln Gly Arg 
            100                 105                 110         


Asn Leu Ala Asp Leu Arg Arg Ser Gln Pro Arg Gly Thr Phe Thr Leu 
        115                 120                 125             


Ser Thr Thr Leu Arg Leu Gly Lys Gln Ile Leu Glu Ser Ile Glu Ala 
    130                 135                 140                 


Ile His Ser Val Gly Phe Leu His Arg Asp Ile Lys Pro Ser Asn Phe 
145                 150                 155                 160 


Ala Met Gly Arg Leu Pro Ser Thr Tyr Arg Lys Cys Tyr Met Leu Asp 
                165                 170                 175     


Phe Gly Leu Ala Arg Gln Tyr Thr Asn Thr Thr Gly Asp Val Arg Pro 
            180                 185                 190         


Pro Arg Asn Val Ala Gly Phe Arg Gly Thr Val Arg Tyr Ala Ser Val 
        195                 200                 205             


Asn Ala His Lys Asn Arg Glu Met Gly Arg His Asp Asp Leu Trp Ser 
    210                 215                 220                 


Leu Phe Tyr Met Leu Val Glu Phe Ala Val Gly Gln Leu Pro Trp Arg 
225                 230                 235                 240 


Lys Ile Lys Asp Lys Glu Gln Val Gly Met Ile Lys Glu Lys Tyr Glu 
                245                 250                 255     


His Arg Met Leu Leu Lys His Met Pro Ser Glu Phe His Leu Phe Leu 
            260                 265                 270         


Asp His Ile Ala Ser Leu Asp Tyr Phe Thr Lys Pro Asp Tyr Gln Leu 
        275                 280                 285             


Ile Met Ser Val Phe Glu Asn Ser Met Lys Glu Arg Gly Ile Ala Glu 
    290                 295                 300                 


Asn Glu Ala Phe Asp Trp Glu Lys Ala Gly Thr Asp Ala Leu Leu Ser 
305                 310                 315                 320 


Thr Ser Thr Ser Thr Pro Pro Gln Gln Asn Thr Arg Gln Thr Ala Ala 
                325                 330                 335     


Met Phe Gly Val Val Asn Val Thr Pro Val Pro Gly Asp Leu Leu Arg 
            340                 345                 350         


Glu Asn Thr Glu Asp Val Leu Gln Gly Glu His Leu Ser Asp Gln Glu 
        355                 360                 365             


Asn Ala Pro Pro Ile Leu Pro Gly Arg Pro Ser Glu Gly Leu Gly Pro 
    370                 375                 380                 


Ser Pro His Leu Val Pro His Pro Gly Gly Pro Glu Ala Glu Val Trp 
385                 390                 395                 400 


Glu Glu Thr Asp Val Asn Arg Asn Lys Leu Arg Ile Asn Ile Gly Lys 
                405                 410                 415     


Ser Pro Cys Val Glu Glu Glu Gln Ser Arg Gly Met Gly Val Pro Ser 
            420                 425                 430         


Ser Pro Val Arg Ala Pro Pro Asp Ser Pro Thr Thr Pro Val Arg Ser 
        435                 440                 445             


Leu Arg Tyr Arg Arg Val Asn Ser Pro Glu Ser Glu Arg Leu Ser Thr 
    450                 455                 460                 


Ala Asp Gly Arg Val Glu Leu Pro Glu Arg Arg Ser Arg Met Asp Leu 
465                 470                 475                 480 


Pro Gly Ser Pro Ser Arg Gln Ala Cys Ser Ser Gln Pro Ala Gln Met 
                485                 490                 495     


Leu Ser Val Asp Thr Gly His Ala Asp Arg Gln Ala Ser Gly Arg Met 
            500                 505                 510         


Asp Val Ser Ala Ser Val Glu Gln Glu Ala Leu Ser Asn Ala Phe Arg 
        515                 520                 525             


Ser Val Pro Leu Ala Glu Glu Glu Asp Phe Asp Ser Lys Glu Trp Val 
    530                 535                 540                 


Ile Ile Asp Lys Glu Thr Glu Leu Lys Asp Phe Pro Pro Gly Ala Glu 
545                 550                 555                 560 


Pro Ser Thr Ser Gly Thr Thr Asp Glu Glu Pro Glu Glu Leu Arg Pro 
                565                 570                 575     


Leu Pro Glu Glu Gly Glu Glu Arg Arg Arg Leu Gly Ala Glu Pro Thr 
            580                 585                 590         


Val Arg Pro Arg Gly Arg Ser Met Gln Ala Leu Ala Glu Glu Asp Leu 
        595                 600                 605             


Gln His Leu Pro Pro Gln Pro Leu Pro Pro Gln Leu Ser Gln Gly Asp 
    610                 615                 620                 


Gly Arg Ser Glu Thr Ser Gln Pro Pro Thr Pro Gly Ser Pro Ser His 
625                 630                 635                 640 


Ser Pro Leu His Ser Gly Pro Arg Pro Arg Arg Arg Glu Ser Asp Pro 
                645                 650                 655     


Thr Gly Pro Gln Arg Gln Val Phe Ser Val Ala Pro Pro Phe Glu Val 
            660                 665                 670         


Asn Gly Leu Pro Arg Ala Val Pro Leu Ser Leu Pro Tyr Gln Asp Phe 
        675                 680                 685             


Lys Arg Asp Leu Ser Asp Tyr Arg Glu Arg Ala Arg Leu Leu Asn Arg 
    690                 695                 700                 


Val Arg Arg Val Gly Phe Ser His Met Leu Leu Thr Thr Pro Gln Val 
705                 710                 715                 720 


Pro Leu Ala Pro Val Gln Pro Gln Ala Asn Gly Lys Glu Glu Glu Glu 
                725                 730                 735     


Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
            740                 745                 750         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        755                 760                 765             


Glu Glu Glu Ala Ala Ala Ala Val Ala Leu Gly Glu Val Leu Gly Pro 
    770                 775                 780                 


Arg Ser Gly Ser Ser Ser Glu Gly Ser Glu Arg Ser Thr Asp Arg Ser 
785                 790                 795                 800 


Gln Glu Gly Ala Pro Ser Thr Leu Leu Ala Asp Asp Gln Lys Glu Ser 
                805                 810                 815     


Arg Gly Arg Ala Ser Met Ala Asp Gly Asp Leu Glu Pro Glu Glu Gly 
            820                 825                 830         


Ser Lys Thr Leu Val Leu Val Ser Pro Gly Asp Met Lys Lys Ser Pro 
        835                 840                 845             


Val Thr Ala Glu Leu Ala Pro Asp Pro Asp Leu Gly Thr Leu Ala Ala 
    850                 855                 860                 


Leu Thr Pro Gln His Glu Arg Pro Gln Pro Thr Gly Ser Gln Leu Asp 
865                 870                 875                 880 


Val Ser Glu Pro Gly Thr Leu Ser Ser Val Leu Lys Ser Glu Pro Lys 
                885                 890                 895     


Pro Pro Gly Pro Gly Ala Gly Leu Gly Ala Gly Thr Val Thr Thr Gly 
            900                 905                 910         


Val Gly Gly Val Ala Val Thr Ser Ser Pro Phe Thr Lys Val Glu Arg 
        915                 920                 925             


Thr Phe Val His Ile Ala Glu Lys Thr His Leu Asn Val Met Ser Ser 
    930                 935                 940                 


Gly Gly Gln Ala Leu Arg Ser Glu Glu Phe Ser Ala Gly Gly Glu Leu 
945                 950                 955                 960 


Gly Leu Glu Leu Ala Ser Asp Gly Gly Ala Val Glu Glu Gly Ala Arg 
                965                 970                 975     


Ala Pro Leu Glu Asn Gly Leu Ala Leu Ser Gly Leu Asn Gly Ala Glu 
            980                 985                 990         


Ile Glu Gly Ser Ala Leu Ser Gly  Ala Pro Arg Glu Thr  Pro Ser Glu 
        995                 1000                 1005             


Met Ala  Thr Asn Ser Leu Pro  Asn Gly Pro Ala Leu  Ala Asp Gly 
    1010                 1015                 1020             


Pro Ala  Pro Val Ser Pro Leu  Glu Pro Ser Pro Glu  Lys Val Ala 
    1025                 1030                 1035             


Thr Ile  Ser Pro Arg Arg His  Ala Met Pro Gly Ser  Arg Pro Arg 
    1040                 1045                 1050             


Ser Arg  Ile Pro Val Leu Leu  Ser Glu Glu Asp Thr  Gly Ser Glu 
    1055                 1060                 1065             


Pro Ser  Gly Ser Leu Ser Ala  Lys Glu Arg Trp Ser  Lys Arg Ala 
    1070                 1075                 1080             


Arg Pro  Gln Gln Asp Leu Ala  Arg Leu Val Met Glu  Lys Arg Gln 
    1085                 1090                 1095             


Gly Arg  Leu Leu Leu Arg Leu  Ala Ser Gly Ala Ser  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Glu Gln Arg Arg Ala  Ser Glu Thr Leu Ser  Gly Thr Gly 
    1115                 1120                 1125             


Ser Glu  Glu Asp Thr Pro Ala  Ser Glu Pro Ala Ala  Ala Leu Pro 
    1130                 1135                 1140             


Arg Lys  Ser Gly Arg Ala Ala  Ala Thr Arg Ser Arg  Ile Pro Arg 
    1145                 1150                 1155             


Pro Ile  Gly Leu Arg Met Pro  Met Pro Val Ala Ala  Gln Gln Pro 
    1160                 1165                 1170             


Ala Ser  Arg Ser His Gly Ala  Ala Pro Ala Leu Asp  Thr Ala Ile 
    1175                 1180                 1185             


Thr Ser  Arg Leu Gln Leu Gln  Thr Pro Pro Gly Ser  Ala Thr Ala 
    1190                 1195                 1200             


Ala Asp  Leu Arg Pro Lys Gln  Pro Pro Gly Arg Gly  Leu Gly Pro 
    1205                 1210                 1215             


Gly Arg  Ala Gln Ala Gly Ala  Arg Pro Pro Ala Pro  Arg Ser Pro 
    1220                 1225                 1230             


Arg Leu  Pro Ala Ser Thr Ser  Ala Ala Arg Asn Ala  Ser Ala Ser 
    1235                 1240                 1245             


Pro Arg  Ser Gln Ser Leu Ser  Arg Arg Glu Ser Pro  Ser Pro Ser 
    1250                 1255                 1260             


His Gln  Ala Arg Pro Gly Val  Pro Pro Pro Arg Gly  Val Pro Pro 
    1265                 1270                 1275             


Ala Arg  Ala Gln Pro Asp Gly  Thr Pro Ser Pro Gly  Gly Ser Lys 
    1280                 1285                 1290             


Lys Gly  Pro Arg Gly Lys Leu  Gln Ala Gln Arg Ala  Thr Thr Lys 
    1295                 1300                 1305             


Gly Arg  Ala Gly Gly Ala Glu  Gly Arg Ala Gly Ala  Arg 
    1310                 1315                 1320     


<210> 4876
<211> 605
<212> PRT
<213> Homo sapiens

<400> 4876
Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ala Arg 
1               5                   10                  15      


Tyr Thr Asp Ala His Tyr Ala Lys Ser Gly Tyr Gly Ala Tyr Thr Pro 
            20                  25                  30          


Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Leu Leu Glu Lys Glu Lys 
        35                  40                  45              


Leu Gly Phe Lys Pro Val Pro Thr Ser Ser Phe Leu Thr Arg Pro Arg 
    50                  55                  60                  


Thr Tyr Gly Pro Ser Ser Leu Leu Asp Tyr Asp Arg Gly Arg Pro Leu 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Thr Gly Gly Gly Lys Arg Ala Glu Ser Gln Thr 
                85                  90                  95      


Arg Gly Thr Glu Arg Pro Leu Gly Ser Gly Leu Ser Gly Gly Ser Gly 
            100                 105                 110         


Phe Pro Tyr Gly Val Thr Asn Asn Cys Leu Ser Tyr Leu Pro Ile Asn 
        115                 120                 125             


Ala Tyr Asp Gln Gly Val Thr Leu Thr Gln Lys Leu Asp Ser Gln Ser 
    130                 135                 140                 


Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr Arg 
145                 150                 155                 160 


Ile Asp Pro Arg Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg 
                165                 170                 175     


Lys Glu Leu Cys Thr Leu Gln Gly Leu Tyr Gln Thr Ala Ser Cys Pro 
            180                 185                 190         


Glu Tyr Leu Val Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala 
        195                 200                 205             


Ser Gln Val Pro Ser Gln Ala Pro Pro Ser Arg Val Pro Glu Ile Ile 
    210                 215                 220                 


Ser Pro Thr Tyr Arg Pro Ile Gly Arg Tyr Thr Leu Trp Glu Thr Gly 
225                 230                 235                 240 


Lys Gly Gln Ala Pro Gly Pro Ser Arg Ser Ser Ser Pro Gly Arg Asp 
                245                 250                 255     


Gly Met Asn Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu 
            260                 265                 270         


Gly Asn Thr Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr 
        275                 280                 285             


Arg Glu Leu Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu 
    290                 295                 300                 


His His Gly Ser Asn Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys 
305                 310                 315                 320 


Leu Ile Gln Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro 
                325                 330                 335     


Ser Glu Phe Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly 
            340                 345                 350         


Tyr Asn Gln Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly 
        355                 360                 365             


Leu His Asn Glu Val Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro 
    370                 375                 380                 


Glu Asn Leu Asp His Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp 
385                 390                 395                 400 


Arg Lys Tyr Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val 
                405                 410                 415     


Gly Gln Leu Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser 
            420                 425                 430         


Thr Val Phe Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg 
        435                 440                 445             


Gly Tyr Pro Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys 
    450                 455                 460                 


Glu Asp Val Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg 
465                 470                 475                 480 


Gly Arg Lys Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys 
                485                 490                 495     


Ile Leu Val Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr 
            500                 505                 510         


Ser Lys Leu Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu 
        515                 520                 525             


Arg Glu Phe Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr 
    530                 535                 540                 


Ala Val Ser Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala 
545                 550                 555                 560 


Tyr Cys Arg Ser Pro Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser 
                565                 570                 575     


Ser Val Thr Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr 
            580                 585                 590         


Leu Leu Phe Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
        595                 600                 605 


<210> 4877
<211> 450
<212> PRT
<213> Homo sapiens

<400> 4877
Met Val Pro Leu Val Ala Val Val Ser Gly Pro Arg Ala Gln Leu Phe 
1               5                   10                  15      


Ala Cys Leu Leu Arg Leu Gly Thr Gln Gln Val Gly Pro Leu Gln Leu 
            20                  25                  30          


His Thr Gly Ala Ser His Ala Ala Arg Asn His Tyr Glu Val Leu Val 
        35                  40                  45              


Leu Gly Gly Gly Ser Gly Gly Ile Thr Met Ala Ala Arg Met Lys Arg 
    50                  55                  60                  


Lys Val Gly Ala Glu Asn Val Ala Ile Val Glu Pro Ser Glu Arg His 
65                  70                  75                  80  


Phe Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala Gly Ala Lys Gln Leu 
                85                  90                  95      


Ser Ser Ser Gly Arg Pro Thr Ala Ser Val Ile Pro Ser Gly Val Glu 
            100                 105                 110         


Trp Ile Lys Ala Arg Val Thr Glu Leu Asn Pro Asp Lys Asn Cys Ile 
        115                 120                 125             


His Thr Asp Asp Asp Glu Lys Ile Ser Tyr Arg Tyr Leu Ile Ile Ala 
    130                 135                 140                 


Leu Gly Ile Gln Leu Asp Tyr Glu Lys Ile Lys Gly Leu Pro Glu Gly 
145                 150                 155                 160 


Phe Ala His Pro Lys Ile Gly Ser Asn Tyr Ser Val Lys Thr Val Glu 
                165                 170                 175     


Lys Thr Trp Lys Ala Leu Gln Asp Phe Lys Glu Gly Asn Ala Ile Phe 
            180                 185                 190         


Thr Phe Pro Asn Thr Pro Val Lys Cys Ala Gly Ala Pro Gln Lys Ile 
        195                 200                 205             


Met Tyr Leu Ser Glu Ala Tyr Phe Arg Lys Thr Gly Lys Arg Ser Lys 
    210                 215                 220                 


Ala Asn Ile Ile Phe Asn Thr Ser Leu Gly Ala Ile Phe Gly Val Lys 
225                 230                 235                 240 


Lys Tyr Ala Asp Ala Leu Gln Glu Ile Ile Gln Glu Arg Asn Leu Thr 
                245                 250                 255     


Val Asn Tyr Lys Lys Asn Leu Ile Glu Val Arg Ala Asp Lys Gln Glu 
            260                 265                 270         


Ala Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr Gln Val Ile Ser 
        275                 280                 285             


Tyr Glu Met Leu His Val Thr Pro Pro Met Ser Pro Pro Asp Val Leu 
    290                 295                 300                 


Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val Asp Val Asp Lys 
305                 310                 315                 320 


Glu Thr Leu Gln His Arg Arg Tyr Pro Asn Val Phe Gly Ile Gly Asp 
                325                 330                 335     


Cys Thr Asn Leu Pro Thr Ser Lys Thr Ala Ala Ala Val Ala Ala Gln 
            340                 345                 350         


Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met Lys Asn Gln Thr 
        355                 360                 365             


Pro Thr Lys Lys Tyr Asp Gly Tyr Thr Ser Cys Pro Leu Val Thr Gly 
    370                 375                 380                 


Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys Ala Glu Pro Leu 
385                 390                 395                 400 


Glu Thr Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu Ser Met Tyr Leu 
                405                 410                 415     


Met Lys Ala Asp Leu Met Pro Phe Leu Tyr Trp Asn Met Met Leu Arg 
            420                 425                 430         


Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu Phe His Leu Gly 
        435                 440                 445             


Met Ser 
    450 


<210> 4878
<211> 1747
<212> PRT
<213> Homo sapiens

<400> 4878
Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu 
1               5                   10                  15      


Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser 
            20                  25                  30          


Pro Leu Gln Asp Leu Arg Gly Gly Asn Glu Arg Val Gln Glu Ser Asn 
        35                  40                  45              


Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr 
    50                  55                  60                  


Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser 
65                  70                  75                  80  


Glu Met Glu Glu Thr Glu Thr Gly Glu Asn Leu Leu Leu Ile Gln Asn 
                85                  90                  95      


Lys Lys Leu Glu Asp Asn Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu 
            100                 105                 110         


Leu Ser Ala Pro Ile His Thr Gln Met Gln Gln Lys Glu Phe Ser Ile 
        115                 120                 125             


Ile Glu His Thr Arg Glu Arg Lys His Ala Asn Asp Gln Thr Val Ile 
    130                 135                 140                 


Phe Ser Asp Glu Asn Gln Met Asp Leu Thr Ser Ser His Thr Val Met 
145                 150                 155                 160 


Ile Thr Lys Gly Leu Leu Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys 
                165                 170                 175     


Ile Asp Thr Thr Ser Phe Leu Ala Asn Leu Lys Leu His Thr Glu Asp 
            180                 185                 190         


Ser Arg Met Lys Lys Glu Val Asn Phe Ser Val Asp Gln Asn Thr Ser 
        195                 200                 205             


Ser Glu Asn Lys Ile Asp Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr 
    210                 215                 220                 


Gly Lys Cys Ser Ala Phe Pro Asp Val Pro Asp Lys Glu Asn Phe Glu 
225                 230                 235                 240 


Ile Pro Ile Tyr Ser Lys Glu Pro Asn Ser Ala Ser Ser Thr His Gln 
                245                 250                 255     


Met His Val Ser Leu Lys Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg 
            260                 265                 270         


Leu Phe Arg Glu Lys Asp Asp Gly Met Asn Phe Thr Gln Cys His Thr 
        275                 280                 285             


Ala Asn Ile Gln Thr Leu Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg 
    290                 295                 300                 


Glu Ser Lys Gly Asn Asp Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp 
305                 310                 315                 320 


Leu Thr Phe Asn His Thr Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe 
                325                 330                 335     


Ser Glu Ile Glu Asn Gln Thr Gln Asn Ala Met Asp Val Thr Thr Gly 
            340                 345                 350         


Tyr Gly Thr Lys Ala Ser Gly Asn Lys Thr Val Phe Lys Ser Lys Gln 
        355                 360                 365             


Asn Thr Ala Phe Gln Asp Leu Ser Ile Asn Ser Ala Asp Lys Ile His 
    370                 375                 380                 


Ile Thr Arg Ser His Ile Met Gly Ala Glu Thr His Ile Val Ser Gln 
385                 390                 395                 400 


Thr Cys Asn Gln Asp Ala Arg Ile Leu Ala Met Thr Pro Glu Ser Ile 
                405                 410                 415     


Tyr Ser Asn Pro Ser Ile Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser 
            420                 425                 430         


Cys Asn Asp Ala Met Glu Met Thr Lys Cys Leu Ser Asn Met Arg Glu 
        435                 440                 445             


Glu Lys Asn Leu Leu Lys His Asp Ser Asn Tyr Ala Lys Met Tyr Cys 
    450                 455                 460                 


Asn Pro Asp Ala Met Ser Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly 
465                 470                 475                 480 


Glu Glu Asn Met Asp Ile Thr Lys Ser His Thr Val Ala Ile Asp Asn 
                485                 490                 495     


Gln Ile Phe Lys Gln Asp Gln Ser Asn Val Gln Ile Ala Ala Ala Pro 
            500                 505                 510         


Thr Pro Glu Lys Glu Met Met Leu Gln Asn Leu Met Thr Thr Ser Glu 
        515                 520                 525             


Asp Gly Lys Met Asn Val Asn Cys Asn Ser Val Pro His Val Ser Lys 
    530                 535                 540                 


Glu Arg Ile Gln Gln Ser Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr 
545                 550                 555                 560 


Asp Arg Lys Thr Glu Leu Leu Ser Gly Glu Asn Met Asp Leu Thr Glu 
                565                 570                 575     


Ser His Thr Ser Asn Leu Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn 
            580                 585                 590         


Leu Ala Pro Glu Ser Thr Ser Glu Ser His Ser Gln Ser Lys Ser Ser 
        595                 600                 605             


Ser Asp Glu Cys Glu Glu Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln 
    610                 615                 620                 


Arg Ser Asp Ile Ile Ala Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys 
625                 630                 635                 640 


Asp Lys Asp Trp Val Leu Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser 
                645                 650                 655     


Pro Gln Ser Ala Asp Cys Asn Gln Glu Ile Ala Thr Ser His Asn Ile 
            660                 665                 670         


Val Tyr Cys Gly Gly Val Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr 
        675                 680                 685             


Val Ser Trp Glu Gln Ser Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser 
    690                 695                 700                 


Ser Gly Gln Phe Ser Met Lys Asn His Asp Thr Ala Ile Ser Ser His 
705                 710                 715                 720 


Thr Val Lys Ser Val Leu Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu 
                725                 730                 735     


Arg Lys Ser Leu Ser Asn Pro Thr Pro Asp Tyr Cys His Asp Lys Met 
            740                 745                 750         


Ile Ile Cys Ser Glu Glu Glu Gln Asn Met Asp Leu Thr Lys Ser His 
        755                 760                 765             


Thr Val Val Ile Gly Phe Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys 
    770                 775                 780                 


Thr Asn Leu Glu His Thr Thr Gly Gln Leu Thr Thr Met Asn Arg Gln 
785                 790                 795                 800 


Ile Ala Val Lys Val Glu Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser 
                805                 810                 815     


Gly Val Leu Lys Ser Asn Cys Ile Met Asp Val Leu Glu Asp Glu Ser 
            820                 825                 830         


Val Gln Lys Pro Lys Phe Pro Lys Glu Lys Gln Asn Val Lys Ile Trp 
        835                 840                 845             


Gly Arg Lys Ser Val Gly Gly Pro Lys Ile Asp Lys Thr Ile Val Phe 
    850                 855                 860                 


Ser Glu Asp Asp Lys Asn Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile 
865                 870                 875                 880 


Glu Ile Asn His Arg Pro Leu Leu Glu Lys Arg Asp Cys His Leu Val 
                885                 890                 895     


Pro Leu Ala Gly Thr Ser Glu Thr Ile Leu Tyr Thr Cys Arg Gln Asp 
            900                 905                 910         


Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu Glu Cys Lys Thr 
        915                 920                 925             


Val Ser Pro Asp Glu Ile Thr Thr Arg Pro Met Asp Lys Thr Val Val 
    930                 935                 940                 


Phe Val Asp Asn His Val Glu Leu Glu Met Thr Glu Ser His Thr Val 
945                 950                 955                 960 


Phe Ile Asp Tyr Gln Glu Lys Glu Arg Thr Asp Arg Pro Asn Phe Glu 
                965                 970                 975     


Leu Ser Gln Arg Lys Ser Leu Gly Thr Pro Thr Val Ile Cys Thr Pro 
            980                 985                 990         


Thr Glu Glu Ser Val Phe Phe Pro  Gly Asn Gly Glu Ser  Asp Arg Leu 
        995                 1000                 1005             


Val Ala  Asn Asp Ser Gln Leu  Thr Pro Leu Glu Glu  Trp Ser Asn 
    1010                 1015                 1020             


Asn Arg  Gly Pro Val Glu Val  Ala Asp Asn Met Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ser Ala  Thr Cys Lys Asn Ile  Lys Asp Val Gln Ser  Pro Gly Phe 
    1040                 1045                 1050             


Leu Asn  Glu Pro Leu Ser Ser  Lys Ser Gln Arg Arg  Lys Ser Leu 
    1055                 1060                 1065             


Lys Leu  Lys Asn Asp Lys Thr  Ile Val Phe Ser Glu  Asn His Lys 
    1070                 1075                 1080             


Asn Asp  Met Asp Ile Thr Gln  Ser Cys Met Val Glu  Ile Asp Asn 
    1085                 1090                 1095             


Glu Ser  Ala Leu Glu Asp Lys  Glu Asp Phe His Leu  Ala Gly Ala 
    1100                 1105                 1110             


Ser Lys  Thr Ile Leu Tyr Ser  Cys Gly Gln Asp Asp  Met Glu Ile 
    1115                 1120                 1125             


Thr Arg  Ser His Thr Thr Ala  Leu Glu Cys Lys Thr  Leu Leu Pro 
    1130                 1135                 1140             


Asn Glu  Ile Ala Ile Arg Pro  Met Asp Lys Thr Val  Leu Phe Thr 
    1145                 1150                 1155             


Asp Asn  Tyr Ser Asp Leu Glu  Val Thr Asp Ser His  Thr Val Phe 
    1160                 1165                 1170             


Ile Asp  Cys Gln Ala Thr Glu  Lys Ile Leu Glu Glu  Asn Pro Lys 
    1175                 1180                 1185             


Phe Gly  Ile Gly Lys Gly Lys  Asn Leu Gly Val Ser  Phe Pro Lys 
    1190                 1195                 1200             


Asp Asn  Ser Cys Val Gln Glu  Ile Ala Glu Lys Gln  Ala Leu Ala 
    1205                 1210                 1215             


Val Gly  Asn Lys Ile Val Leu  His Thr Glu Gln Lys  Gln Gln Leu 
    1220                 1225                 1230             


Phe Ala  Ala Thr Asn Arg Thr  Thr Asn Glu Ile Ile  Lys Phe His 
    1235                 1240                 1245             


Ser Ala  Ala Met Asp Glu Lys  Val Ile Gly Lys Val  Val Asp Gln 
    1250                 1255                 1260             


Ala Cys  Thr Leu Glu Lys Ala  Gln Val Glu Ser Cys  Gln Leu Asn 
    1265                 1270                 1275             


Asn Arg  Asp Arg Arg Asn Val  Asp Phe Thr Ser Ser  His Ala Thr 
    1280                 1285                 1290             


Ala Val  Cys Gly Ser Ser Asp  Asn Tyr Ser Cys Leu  Pro Asn Val 
    1295                 1300                 1305             


Ile Ser  Cys Thr Asp Asn Leu  Glu Gly Ser Ala Met  Leu Leu Cys 
    1310                 1315                 1320             


Asp Lys  Asp Glu Glu Lys Ala  Asn Tyr Cys Pro Val  Gln Asn Asp 
    1325                 1330                 1335             


Leu Ala  Tyr Ala Asn Asp Phe  Ala Ser Glu Tyr Tyr  Leu Glu Ser 
    1340                 1345                 1350             


Glu Gly  Gln Pro Leu Ser Ala  Pro Cys Pro Leu Leu  Glu Lys Glu 
    1355                 1360                 1365             


Glu Val  Ile Gln Thr Ser Thr  Lys Gly Gln Leu Asp  Cys Val Ile 
    1370                 1375                 1380             


Thr Leu  His Lys Asp Gln Asp  Leu Ile Lys Asp Pro  Arg Asn Leu 
    1385                 1390                 1395             


Leu Ala  Asn Gln Thr Leu Val  Tyr Ser Gln Asp Leu  Gly Glu Met 
    1400                 1405                 1410             


Thr Lys  Leu Asn Ser Lys Arg  Val Ser Phe Lys Leu  Pro Lys Asp 
    1415                 1420                 1425             


Gln Met  Lys Val Tyr Val Asp  Asp Ile Tyr Val Ile  Pro Gln Pro 
    1430                 1435                 1440             


His Phe  Ser Thr Asp Gln Pro  Pro Leu Pro Lys Lys  Gly Gln Ser 
    1445                 1450                 1455             


Ser Ile  Asn Lys Glu Glu Val  Ile Leu Ser Lys Ala  Gly Asn Lys 
    1460                 1465                 1470             


Ser Leu  Asn Ile Ile Glu Asn  Ser Ser Ala Pro Ile  Cys Glu Asn 
    1475                 1480                 1485             


Lys Pro  Lys Ile Leu Asn Ser  Glu Glu Trp Phe Ala  Ala Ala Cys 
    1490                 1495                 1500             


Lys Lys  Glu Leu Lys Glu Asn  Ile Gln Thr Thr Asn  Tyr Asn Thr 
    1505                 1510                 1515             


Ala Leu  Asp Phe His Ser Asn  Ser Asp Val Thr Lys  Gln Val Ile 
    1520                 1525                 1530             


Gln Thr  His Val Asn Ala Gly  Glu Ala Pro Asp Pro  Val Ile Thr 
    1535                 1540                 1545             


Ser Asn  Val Pro Cys Phe His  Ser Ile Lys Pro Asn  Leu Asn Asn 
    1550                 1555                 1560             


Leu Asn  Gly Lys Thr Gly Glu  Phe Leu Ala Phe Gln  Thr Val His 
    1565                 1570                 1575             


Leu Pro  Pro Leu Pro Glu Gln  Leu Leu Glu Leu Gly  Asn Lys Ala 
    1580                 1585                 1590             


His Asn  Asp Met His Ile Val  Gln Ala Thr Glu Ile  His Asn Ile 
    1595                 1600                 1605             


Asn Ile  Ile Ser Ser Asn Ala  Lys Asp Ser Arg Asp  Glu Glu Asn 
    1610                 1615                 1620             


Lys Lys  Ser His Asn Gly Ala  Glu Thr Thr Ser Leu  Pro Pro Lys 
    1625                 1630                 1635             


Thr Val  Phe Lys Asp Lys Val  Arg Arg Cys Ser Leu  Gly Ile Phe 
    1640                 1645                 1650             


Leu Pro  Arg Leu Pro Asn Lys  Arg Asn Cys Ser Val  Thr Gly Ile 
    1655                 1660                 1665             


Asp Asp  Leu Glu Gln Ile Pro  Ala Asp Thr Thr Asp  Ile Asn His 
    1670                 1675                 1680             


Leu Glu  Thr Gln Pro Val Ser  Ser Lys Asp Ser Gly  Ile Gly Ser 
    1685                 1690                 1695             


Val Ala  Gly Lys Leu Asn Leu  Ser Pro Ser Gln Tyr  Ile Asn Glu 
    1700                 1705                 1710             


Glu Asn  Leu Pro Val Tyr Pro  Asp Glu Ile Asn Ser  Ser Asp Ser 
    1715                 1720                 1725             


Ile Asn  Ile Glu Thr Glu Pro  Lys Lys Asn Val Gly  Thr Arg Arg 
    1730                 1735                 1740             


Arg Arg  Tyr Ser 
    1745         


<210> 4879
<211> 686
<212> PRT
<213> Homo sapiens

<400> 4879
Met Ile Pro Gly Lys Tyr Arg Ser Val Ser Gly Arg Ala Ala Asn Asn 
1               5                   10                  15      


Val Asn Cys Gly Leu His Leu Val Ile Gln Thr Ser Ser Leu Pro Glu 
            20                  25                  30          


Lys Asn Lys Val Glu Phe Lys Leu Asn Lys Asp Thr Ser Ser Phe Pro 
        35                  40                  45              


Gly Arg Leu Leu Gln His Asp Leu Glu Arg Asn Tyr Ser Ser Arg Gln 
    50                  55                  60                  


Gly Asp His Ile Asn Leu Val Ser Ser Ser Leu Ser Ser Phe Pro Ile 
65                  70                  75                  80  


Leu Gln Arg Ser Ser Glu Glu Lys Ile Leu Tyr Ser Asp Arg Leu Ser 
                85                  90                  95      


Leu Glu Arg Gln Lys Leu Thr Val Cys Pro Ile Ile Asn Gly Glu Asp 
            100                 105                 110         


His Leu Arg Leu Leu Asn Phe Gln His Asn Phe Ile Thr Arg Ile Gln 
        115                 120                 125             


Asn Ile Ser Asn Leu Gln Lys Leu Ile Ser Leu Asp Leu Tyr Asp Asn 
    130                 135                 140                 


Gln Ile Glu Glu Ile Ser Gly Leu Ser Thr Leu Arg Cys Leu Arg Val 
145                 150                 155                 160 


Leu Leu Leu Gly Lys Asn Arg Ile Lys Lys Ile Ser Asn Leu Glu Asn 
                165                 170                 175     


Leu Lys Ser Leu Asp Val Leu Asp Leu His Gly Asn Gln Ile Thr Lys 
            180                 185                 190         


Ile Glu Asn Ile Asn His Leu Cys Glu Leu Arg Val Leu Asn Leu Ala 
        195                 200                 205             


Arg Asn Phe Leu Ser His Val Asp Asn Leu Asn Gly Leu Asp Ser Leu 
    210                 215                 220                 


Thr Glu Leu Asn Leu Arg His Asn Gln Ile Thr Phe Val Arg Asp Val 
225                 230                 235                 240 


Asp Asn Leu Pro Cys Leu Gln His Leu Phe Leu Ser Phe Asn Asn Ile 
                245                 250                 255     


Ser Ser Phe Asp Ser Val Ser Cys Leu Ala Asp Ser Ser Ser Leu Ser 
            260                 265                 270         


Asp Ile Thr Phe Asp Gly Asn Pro Ile Ala Gln Glu Ser Trp Tyr Lys 
        275                 280                 285             


His Thr Val Leu Gln Asn Met Met Gln Leu Arg Gln Leu Asp Met Lys 
    290                 295                 300                 


Arg Ile Thr Glu Glu Glu Arg Arg Met Ala Ser Val Leu Ala Lys Lys 
305                 310                 315                 320 


Glu Glu Glu Lys Lys Arg Glu Ser His Lys Gln Ser Leu Leu Lys Glu 
                325                 330                 335     


Lys Lys Arg Leu Thr Ile Asn Asn Val Ala Arg Gln Trp Asp Leu Gln 
            340                 345                 350         


Gln Gln Arg Val Ala Asn Ile Ala Thr Asn Glu Asp Arg Lys Asp Ser 
        355                 360                 365             


Asp Ser Pro Gln Asp Pro Cys Gln Ile Asp Gly Ser Thr Leu Ser Ala 
    370                 375                 380                 


Phe Pro Glu Glu Thr Gly Pro Leu Asp Ser Gly Leu Asn Asn Ala Leu 
385                 390                 395                 400 


Gln Gly Leu Ser Val Ile Asp Thr Tyr Leu Val Glu Val Asp Gly Asp 
                405                 410                 415     


Thr Leu Ser Leu Tyr Gly Ser Gly Ala Leu Glu Ser Leu Asp Arg Asn 
            420                 425                 430         


Trp Ser Val Gln Thr Ala Gly Met Ile Thr Thr Val Ser Phe Thr Phe 
        435                 440                 445             


Ile Glu Phe Asp Glu Ile Val Gln Val Leu Pro Lys Leu Lys Ile Lys 
    450                 455                 460                 


Phe Pro Asn Ser Leu His Leu Lys Phe Lys Glu Thr Asn Leu Val Met 
465                 470                 475                 480 


Leu Gln Gln Phe Asn Ala Leu Ala Gln Leu Arg Arg Ile Asp Gln Leu 
                485                 490                 495     


Thr Ile Asp Pro Gln Gly Asn Pro Val Val Asn Phe Thr Leu Trp Lys 
            500                 505                 510         


Tyr Tyr Val Leu Phe Arg Leu Ser His Phe Ser Met Gln Lys Ile Asn 
        515                 520                 525             


Gly Thr Glu Val Thr Gln Asn Asp Met Ile Met Ala Glu Arg Leu Phe 
    530                 535                 540                 


Gly Ile Leu Ala His Val Ala Ser Ser Glu Leu Pro Gln Tyr Arg Leu 
545                 550                 555                 560 


Ile Ser Ile Leu Gly Asp Ala Arg Lys Lys Gln Phe Arg Tyr Leu Leu 
                565                 570                 575     


Glu Ser Lys Gly Lys Lys Pro Gly Ile Ile Asn Glu Glu Asn Asn Asp 
            580                 585                 590         


Ser Lys Arg Leu Val Gly Glu Asn Thr Asn Arg Ala Thr Leu Asn Tyr 
        595                 600                 605             


Thr Thr Arg Asp Phe Tyr Asn Glu Lys Leu Glu Glu Ile Lys Glu Lys 
    610                 615                 620                 


Lys Lys Phe Cys Lys Thr Tyr Ile Glu Asp Leu Val Lys Glu Ala Thr 
625                 630                 635                 640 


Glu Ile Asn Met Lys Asn Glu Ala Leu Gln Lys Leu Trp Pro Gln Met 
                645                 650                 655     


Phe Ile Glu Leu Val Arg Asp Ala Val Ile Glu Ile Arg Asn Lys Asn 
            660                 665                 670         


Ser Tyr Met Lys Leu Cys Leu Gln Gln Ile Thr Asp Gln Lys 
        675                 680                 685     


<210> 4880
<211> 84
<212> PRT
<213> Homo sapiens

<400> 4880
Met Pro Tyr Leu Leu Ile Ser Thr Gln Ile Arg Met Glu Val Gly Pro 
1               5                   10                  15      


Thr Met Val Gly Asp Glu Gln Ser Asp Pro Glu Leu Met Gln His Leu 
            20                  25                  30          


Gly Ala Ser Lys Arg Arg Ala Leu Gly Asn Asn Phe Tyr Glu Tyr Tyr 
        35                  40                  45              


Val Asp Asp Pro Pro Arg Ile Val Leu Asp Lys Leu Glu Arg Arg Gly 
    50                  55                  60                  


Phe Arg Val Leu Ser Met Thr Gly Val Gly Gln Thr Leu Val Trp Cys 
65                  70                  75                  80  


Leu His Lys Glu 
                


<210> 4881
<211> 887
<212> PRT
<213> Homo sapiens

<400> 4881
Met Pro Ser Leu Pro Gln Glu Gly Val Ile Gln Gly Pro Ser Pro Leu 
1               5                   10                  15      


Asp Leu Asn Thr Glu Leu Pro Tyr Gln Ser Thr Met Lys Arg Lys Val 
            20                  25                  30          


Arg Lys Lys Lys Lys Lys Gly Thr Ile Thr Ala Asn Val Ala Gly Thr 
        35                  40                  45              


Lys Phe Glu Ile Val Arg Leu Val Ile Asp Glu Met Gly Phe Met Lys 
    50                  55                  60                  


Thr Pro Asp Glu Asp Glu Thr Ser Asn Leu Ile Trp Cys Asp Ser Ala 
65                  70                  75                  80  


Val Gln Gln Glu Lys Ile Ser Glu Leu Gln Asn Tyr Gln Arg Ile Asn 
                85                  90                  95      


His Phe Pro Gly Met Gly Glu Ile Cys Arg Lys Asp Phe Leu Ala Arg 
            100                 105                 110         


Asn Met Thr Lys Met Ile Lys Ser Arg Pro Leu Asp Tyr Thr Phe Val 
        115                 120                 125             


Pro Arg Thr Trp Ile Phe Pro Ala Glu Tyr Thr Gln Phe Gln Asn Tyr 
    130                 135                 140                 


Val Lys Glu Leu Lys Lys Lys Arg Lys Gln Lys Thr Phe Ile Val Lys 
145                 150                 155                 160 


Pro Ala Asn Gly Ala Met Gly His Gly Ile Ser Leu Ile Arg Asn Gly 
                165                 170                 175     


Asp Lys Leu Pro Ser Gln Asp His Leu Ile Val Gln Glu Tyr Ile Glu 
            180                 185                 190         


Lys Pro Phe Leu Met Glu Gly Tyr Lys Phe Asp Leu Arg Ile Tyr Ile 
        195                 200                 205             


Leu Val Thr Ser Cys Asp Pro Leu Lys Ile Phe Leu Tyr His Asp Gly 
    210                 215                 220                 


Leu Val Arg Met Gly Thr Glu Lys Tyr Ile Pro Pro Asn Glu Ser Asn 
225                 230                 235                 240 


Leu Thr Gln Leu Tyr Met His Leu Thr Asn Tyr Ser Val Asn Lys His 
                245                 250                 255     


Asn Glu His Phe Glu Arg Asp Glu Thr Glu Asn Lys Gly Ser Lys Arg 
            260                 265                 270         


Ser Ile Lys Trp Phe Thr Glu Phe Leu Gln Ala Asn Gln His Asp Val 
        275                 280                 285             


Ala Lys Phe Trp Ser Asp Ile Ser Glu Leu Val Val Lys Thr Leu Ile 
    290                 295                 300                 


Val Ala Glu Pro His Val Leu His Ala Tyr Arg Met Cys Arg Pro Gly 
305                 310                 315                 320 


Gln Pro Pro Gly Ser Glu Ser Val Cys Phe Glu Val Leu Gly Phe Asp 
                325                 330                 335     


Ile Leu Leu Asp Arg Lys Leu Lys Pro Trp Leu Leu Glu Ile Asn Arg 
            340                 345                 350         


Ala Pro Ser Phe Gly Thr Asp Gln Lys Ile Asp Tyr Asp Val Lys Arg 
        355                 360                 365             


Gly Val Leu Leu Asn Ala Leu Lys Leu Leu Asn Ile Arg Thr Ser Asp 
    370                 375                 380                 


Lys Arg Arg Asn Leu Ala Lys Gln Lys Ala Glu Ala Gln Arg Arg Leu 
385                 390                 395                 400 


Tyr Gly Gln Asn Ser Ile Lys Arg Leu Leu Pro Gly Ser Ser Asp Trp 
                405                 410                 415     


Glu Gln Gln Arg His Gln Leu Glu Arg Arg Lys Glu Glu Leu Lys Glu 
            420                 425                 430         


Arg Leu Ala Gln Val Arg Lys Gln Ile Ser Arg Glu Glu His Glu Asn 
        435                 440                 445             


Arg His Met Gly Asn Tyr Arg Arg Ile Tyr Pro Pro Glu Asp Lys Ala 
    450                 455                 460                 


Leu Leu Glu Lys Tyr Glu Asn Leu Leu Ala Val Ala Phe Gln Thr Phe 
465                 470                 475                 480 


Leu Ser Gly Arg Ala Ala Ser Phe Gln Arg Glu Leu Asn Asn Pro Leu 
                485                 490                 495     


Lys Arg Met Lys Glu Glu Asp Ile Leu Asp Leu Leu Glu Gln Cys Glu 
            500                 505                 510         


Ile Asp Asp Glu Lys Leu Met Gly Lys Thr Thr Lys Thr Arg Gly Pro 
        515                 520                 525             


Lys Pro Leu Cys Ser Met Pro Glu Ser Thr Glu Ile Met Lys Arg Pro 
    530                 535                 540                 


Lys Tyr Cys Ser Ser Asp Ser Ser Tyr Asp Ser Ser Ser Ser Ser Ser 
545                 550                 555                 560 


Glu Ser Asp Glu Asn Glu Lys Glu Glu Tyr Gln Asn Lys Lys Arg Glu 
                565                 570                 575     


Lys Gln Val Thr Tyr Asn Leu Lys Pro Ser Asn His Tyr Lys Leu Ile 
            580                 585                 590         


Gln Gln Pro Ser Ser Ile Arg Arg Ser Val Ser Cys Pro Arg Ser Ile 
        595                 600                 605             


Ser Ala Gln Ser Pro Ser Ser Gly Asp Thr Arg Pro Phe Ser Ala Gln 
    610                 615                 620                 


Gln Met Ile Ser Val Ser Arg Pro Thr Ser Ala Ser Arg Ser His Ser 
625                 630                 635                 640 


Leu Asn Arg Ala Ser Ser Tyr Met Arg His Leu Pro His Ser Asn Asp 
                645                 650                 655     


Ala Cys Ser Thr Asn Ser Gln Val Ser Glu Ser Leu Arg Gln Leu Lys 
            660                 665                 670         


Thr Lys Glu Gln Glu Asp Asp Leu Thr Ser Gln Thr Leu Phe Val Leu 
        675                 680                 685             


Lys Asp Met Lys Ile Arg Phe Pro Gly Lys Ser Asp Ala Glu Ser Glu 
    690                 695                 700                 


Leu Leu Ile Glu Asp Ile Ile Asp Asn Trp Lys Tyr His Lys Thr Lys 
705                 710                 715                 720 


Val Ala Ser Tyr Trp Leu Ile Lys Leu Asp Ser Val Lys Gln Arg Lys 
                725                 730                 735     


Val Leu Asp Ile Val Lys Thr Ser Ile Arg Thr Val Leu Pro Arg Ile 
            740                 745                 750         


Trp Lys Val Pro Asp Val Glu Glu Val Asn Leu Tyr Arg Ile Phe Asn 
        755                 760                 765             


Arg Val Phe Asn Arg Leu Leu Trp Ser Arg Gly Gln Gly Leu Trp Asn 
    770                 775                 780                 


Cys Phe Cys Asp Ser Gly Ser Ser Trp Glu Ser Ile Phe Asn Lys Ser 
785                 790                 795                 800 


Pro Glu Val Val Thr Pro Leu Gln Leu Gln Cys Cys Gln Arg Leu Val 
                805                 810                 815     


Glu Leu Cys Lys Gln Cys Leu Leu Val Val Tyr Lys Tyr Ala Thr Asp 
            820                 825                 830         


Lys Arg Gly Ser Leu Ser Gly Ile Gly Pro Asp Trp Gly Asn Ser Arg 
        835                 840                 845             


Tyr Leu Leu Pro Gly Ser Thr Gln Phe Phe Leu Arg Thr Pro Thr Tyr 
    850                 855                 860                 


Asn Leu Lys Tyr Asn Ser Pro Gly Met Thr Arg Ser Asn Val Leu Phe 
865                 870                 875                 880 


Thr Ser Arg Tyr Gly His Leu 
                885         


<210> 4882
<211> 379
<212> PRT
<213> Homo sapiens

<400> 4882
Met Ala Gly Pro Arg Val Glu Val Asp Gly Ser Ile Met Glu Gly Gly 
1               5                   10                  15      


Gly Gln Ile Leu Arg Val Ser Thr Ala Leu Ser Cys Leu Leu Gly Leu 
            20                  25                  30          


Pro Leu Arg Val Gln Lys Ile Arg Ala Gly Arg Ser Thr Pro Gly Leu 
        35                  40                  45              


Ser Ser Gly Gly Trp Lys Ser Lys Ile Lys Val Leu Thr Arg Pro Gln 
    50                  55                  60                  


His Leu Ser Gly Leu Glu Met Ile Arg Asp Leu Cys Asp Gly Gln Leu 
65                  70                  75                  80  


Glu Gly Ala Glu Ile Gly Ser Thr Glu Ile Thr Phe Thr Pro Glu Lys 
                85                  90                  95      


Ile Lys Gly Gly Ile His Thr Ala Asp Thr Lys Thr Ala Gly Ser Val 
            100                 105                 110         


Cys Leu Leu Met Gln Val Ser Met Pro Cys Val Leu Phe Ala Ala Ser 
        115                 120                 125             


Pro Ser Glu Leu His Leu Lys Gly Gly Thr Asn Ala Glu Met Ala Pro 
    130                 135                 140                 


Gln Ile Asp Tyr Thr Val Met Val Phe Lys Pro Ile Val Glu Lys Phe 
145                 150                 155                 160 


Gly Phe Ile Phe Asn Cys Asp Ile Lys Thr Arg Gly Tyr Tyr Pro Lys 
                165                 170                 175     


Gly Gly Gly Glu Val Ile Val Arg Met Ser Pro Val Lys Gln Leu Asn 
            180                 185                 190         


Pro Ile Asn Leu Thr Glu Arg Gly Cys Val Thr Lys Ile Tyr Gly Arg 
        195                 200                 205             


Ala Phe Val Ala Gly Val Leu Pro Phe Lys Val Ala Lys Asp Met Ala 
    210                 215                 220                 


Ala Ala Ala Val Arg Cys Ile Arg Lys Glu Ile Arg Asp Leu Tyr Val 
225                 230                 235                 240 


Asn Ile Gln Pro Val Gln Glu Pro Lys Asp Gln Ala Phe Gly Asn Gly 
                245                 250                 255     


Asn Gly Ile Ile Ile Ile Ala Glu Thr Ser Thr Gly Cys Leu Phe Ala 
            260                 265                 270         


Gly Ser Ser Leu Gly Lys Arg Gly Val Asn Ala Asp Lys Val Gly Ile 
        275                 280                 285             


Glu Ala Ala Glu Met Leu Leu Ala Asn Leu Arg His Gly Gly Thr Val 
    290                 295                 300                 


Asp Glu Tyr Leu Gln Asp Gln Leu Ile Val Phe Met Ala Leu Ala Asn 
305                 310                 315                 320 


Gly Val Ser Arg Ile Lys Thr Gly Pro Val Thr Leu His Thr Gln Thr 
                325                 330                 335     


Ala Ile His Phe Ala Glu Gln Ile Ala Lys Ala Lys Phe Ile Val Lys 
            340                 345                 350         


Lys Ser Glu Asp Glu Glu Asp Ala Ala Lys Asp Thr Tyr Ile Ile Glu 
        355                 360                 365             


Cys Gln Gly Ile Gly Met Thr Asn Pro Asn Leu 
    370                 375                 


<210> 4883
<211> 351
<212> PRT
<213> Homo sapiens

<400> 4883
Met Pro Ser Glu Thr Leu Trp Glu Ile Ala Lys Ala Glu Val Glu Lys 
1               5                   10                  15      


Arg Gly Ile Asn Gly Ser Glu Gly Asp Gly Ala Glu Ile Ala Glu Lys 
            20                  25                  30          


Phe Val Phe Phe Ile Gly Ser Lys Asn Gly Gly Lys Thr Thr Ile Ile 
        35                  40                  45              


Leu Arg Cys Leu Asp Arg Asp Glu Pro Pro Lys Pro Thr Leu Ala Leu 
    50                  55                  60                  


Glu Tyr Thr Tyr Gly Arg Arg Ala Lys Gly His Asn Thr Pro Lys Asp 
65                  70                  75                  80  


Ile Ala His Phe Trp Glu Leu Gly Gly Gly Thr Ser Leu Leu Asp Leu 
                85                  90                  95      


Ile Ser Ile Pro Ile Thr Gly Asp Thr Leu Arg Thr Phe Ser Leu Val 
            100                 105                 110         


Leu Val Leu Asp Leu Ser Lys Pro Asn Asp Leu Trp Pro Thr Met Glu 
        115                 120                 125             


Asn Leu Leu Gln Ala Thr Lys Ser His Val Asp Lys Val Ile Met Lys 
    130                 135                 140                 


Leu Gly Lys Thr Asn Ala Lys Ala Val Ser Glu Met Arg Gln Lys Ile 
145                 150                 155                 160 


Trp Asn Asn Met Pro Lys Asp His Pro Asp His Glu Leu Ile Asp Pro 
                165                 170                 175     


Phe Pro Val Pro Leu Val Ile Ile Gly Ser Lys Tyr Asp Val Phe Gln 
            180                 185                 190         


Asp Phe Glu Ser Glu Lys Arg Lys Val Ile Cys Lys Thr Leu Arg Phe 
        195                 200                 205             


Val Ala His Tyr Tyr Gly Ala Ser Leu Met Phe Thr Ser Lys Ser Glu 
    210                 215                 220                 


Ala Leu Leu Leu Lys Ile Arg Gly Val Ile Asn Gln Leu Ala Phe Gly 
225                 230                 235                 240 


Ile Asp Lys Ser Lys Ser Ile Cys Val Asp Gln Asn Lys Pro Leu Phe 
                245                 250                 255     


Ile Thr Ala Gly Leu Asp Ser Phe Gly Gln Ile Gly Ser Pro Pro Val 
            260                 265                 270         


Pro Glu Asn Asp Ile Gly Lys Leu His Ala His Ser Pro Met Glu Leu 
        275                 280                 285             


Trp Lys Lys Val Tyr Glu Lys Leu Phe Pro Pro Lys Ser Ile Asn Thr 
    290                 295                 300                 


Leu Lys Asp Ile Lys Asp Pro Ala Arg Asp Pro Gln Tyr Ala Glu Asn 
305                 310                 315                 320 


Glu Val Asp Glu Met Arg Ile Gln Lys Asp Leu Glu Leu Glu Gln Tyr 
                325                 330                 335     


Lys Arg Ser Ser Ser Lys Ser Trp Lys Gln Ile Glu Leu Asp Ser 
            340                 345                 350     


<210> 4884
<211> 265
<212> PRT
<213> Homo sapiens

<400> 4884
Met Cys Thr Ser Glu Thr Phe Gln Ala Leu Asp Thr Phe Glu Ala Arg 
1               5                   10                  15      


His Asp Asp Ile Val Leu Ala Ser Tyr Pro Lys Cys Gly Ser Asn Trp 
            20                  25                  30          


Ile Leu His Ile Val Ser Glu Leu Ile Tyr Ala Val Ser Lys Lys Lys 
        35                  40                  45              


Tyr Lys Tyr Pro Glu Phe Pro Val Leu Glu Cys Gly Asp Ser Glu Lys 
    50                  55                  60                  


Tyr Gln Arg Met Lys Gly Phe Pro Ser Pro Arg Ile Leu Ala Thr His 
65                  70                  75                  80  


Leu His Tyr Asp Lys Leu Pro Gly Ser Ile Phe Glu Asn Lys Ala Lys 
                85                  90                  95      


Ile Leu Val Ile Phe Arg Asn Pro Lys Asp Thr Ala Val Ser Phe Leu 
            100                 105                 110         


His Phe His Asn Asp Val Pro Asp Ile Pro Ser Tyr Gly Ser Trp Asp 
        115                 120                 125             


Glu Phe Phe Arg Gln Phe Met Lys Gly Gln Val Ser Trp Gly Arg Tyr 
    130                 135                 140                 


Phe Asp Phe Ala Ile Asn Trp Asn Lys His Leu Asp Gly Asp Asn Val 
145                 150                 155                 160 


Lys Phe Ile Leu Tyr Glu Asp Leu Lys Glu Asn Leu Ala Ala Gly Ile 
                165                 170                 175     


Lys Gln Ile Ala Glu Phe Leu Gly Phe Phe Leu Thr Gly Glu Gln Ile 
            180                 185                 190         


Gln Thr Ile Ser Val Gln Ser Thr Phe Gln Ala Met Arg Ala Lys Ser 
        195                 200                 205             


Gln Asp Thr His Gly Ala Val Gly Pro Phe Leu Phe Arg Lys Gly Glu 
    210                 215                 220                 


Val Gly Asp Trp Lys Asn Leu Phe Ser Glu Ile Gln Asn Gln Glu Met 
225                 230                 235                 240 


Asp Glu Lys Phe Lys Glu Cys Leu Ala Gly Thr Ser Leu Gly Ala Lys 
                245                 250                 255     


Leu Lys Tyr Glu Ser Tyr Cys Gln Gly 
            260                 265 


<210> 4885
<211> 1780
<212> PRT
<213> Homo sapiens

<400> 4885
Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      


Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          


Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              


Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  


Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  


Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      


Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         


Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             


Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 


Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 


Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     


Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         


Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        195                 200                 205             


Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    210                 215                 220                 


Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                245                 250                 255     


Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            260                 265                 270         


Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        275                 280                 285             


Pro Val Ser Ser Lys Phe Gln Lys Arg Lys Met Leu Arg Leu Ser Gln 
    290                 295                 300                 


Asp Val Lys Gly Tyr Ser Phe Ile Lys Asp Leu Gln Trp Ile Gln Val 
305                 310                 315                 320 


Ser Asp Ser Lys Glu Ala Tyr Arg Leu Leu Lys Leu Gly Ile Lys His 
                325                 330                 335     


Gln Ser Val Ala Phe Thr Lys Leu Asn Asn Ala Ser Ser Arg Ser His 
            340                 345                 350         


Ser Ile Phe Thr Val Lys Ile Leu Gln Ile Glu Asp Ser Glu Met Ser 
        355                 360                 365             


Arg Val Ile Arg Val Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser 
    370                 375                 380                 


Glu Arg Thr Met Lys Thr Gln Asn Glu Gly Glu Arg Leu Arg Glu Thr 
385                 390                 395                 400 


Gly Asn Ile Asn Thr Ser Leu Leu Thr Leu Gly Lys Cys Ile Asn Val 
                405                 410                 415     


Leu Lys Asn Ser Glu Lys Ser Lys Phe Gln Gln His Val Pro Phe Arg 
            420                 425                 430         


Glu Ser Lys Leu Thr His Tyr Phe Gln Ser Phe Phe Asn Gly Lys Gly 
        435                 440                 445             


Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala Tyr Asp 
    450                 455                 460                 


Glu Thr Leu Asn Val Leu Lys Phe Ser Ala Ile Ala Gln Lys Val Cys 
465                 470                 475                 480 


Val Pro Asp Thr Leu Asn Ser Ser Gln Glu Lys Leu Phe Gly Pro Val 
                485                 490                 495     


Lys Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys Ile 
            500                 505                 510         


Leu Asn Val Lys Arg Ala Thr Ile Ser Trp Glu Asn Ser Leu Glu Asp 
        515                 520                 525             


Leu Met Glu Asp Glu Asp Leu Val Glu Glu Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


Thr Gln Asn Val Glu Thr Lys Leu Leu Asp Glu Asp Leu Asp Lys Thr 
545                 550                 555                 560 


Leu Glu Glu Asn Lys Ala Phe Ile Ser His Glu Glu Lys Arg Lys Leu 
                565                 570                 575     


Leu Asp Leu Ile Glu Asp Leu Lys Lys Lys Leu Ile Asn Glu Lys Lys 
            580                 585                 590         


Glu Lys Leu Thr Leu Glu Phe Lys Ile Arg Glu Glu Val Thr Gln Glu 
        595                 600                 605             


Phe Thr Gln Tyr Trp Ala Gln Arg Glu Ala Asp Phe Lys Glu Thr Leu 
    610                 615                 620                 


Leu Gln Glu Arg Glu Ile Leu Glu Glu Asn Ala Glu Arg Arg Leu Ala 
625                 630                 635                 640 


Ile Phe Lys Asp Leu Val Gly Lys Cys Asp Thr Arg Glu Glu Ala Ala 
                645                 650                 655     


Lys Asp Ile Cys Ala Thr Lys Val Glu Thr Glu Glu Ala Thr Ala Cys 
            660                 665                 670         


Leu Glu Leu Lys Phe Asn Gln Ile Lys Ala Glu Leu Ala Lys Thr Lys 
        675                 680                 685             


Gly Glu Leu Ile Lys Thr Lys Glu Glu Leu Lys Lys Arg Glu Asn Glu 
    690                 695                 700                 


Ser Asp Ser Leu Ile Gln Glu Leu Glu Thr Ser Asn Lys Lys Ile Ile 
705                 710                 715                 720 


Thr Gln Asn Gln Arg Ile Lys Glu Leu Ile Asn Ile Ile Asp Gln Lys 
                725                 730                 735     


Glu Asp Thr Ile Asn Glu Phe Gln Asn Leu Lys Ser His Met Glu Asn 
            740                 745                 750         


Thr Phe Lys Cys Asn Asp Lys Ala Asp Thr Ser Ser Leu Ile Ile Asn 
        755                 760                 765             


Asn Lys Leu Ile Cys Asn Glu Thr Val Glu Val Pro Lys Asp Ser Lys 
    770                 775                 780                 


Ser Lys Ile Cys Ser Glu Arg Lys Arg Val Asn Glu Asn Glu Leu Gln 
785                 790                 795                 800 


Gln Asp Glu Pro Pro Ala Lys Lys Gly Ser Ile His Val Ser Ser Ala 
                805                 810                 815     


Ile Thr Glu Asp Gln Lys Lys Ser Glu Glu Val Arg Pro Asn Ile Ala 
            820                 825                 830         


Glu Ile Glu Asp Ile Arg Val Leu Gln Glu Asn Asn Glu Gly Leu Arg 
        835                 840                 845             


Ala Phe Leu Leu Thr Ile Glu Asn Glu Leu Lys Asn Glu Lys Glu Glu 
    850                 855                 860                 


Lys Ala Glu Leu Asn Lys Gln Ile Val His Phe Gln Gln Glu Leu Ser 
865                 870                 875                 880 


Leu Ser Glu Lys Lys Asn Leu Thr Leu Ser Lys Glu Val Gln Gln Ile 
                885                 890                 895     


Gln Ser Asn Tyr Asp Ile Ala Ile Ala Glu Leu His Val Gln Lys Ser 
            900                 905                 910         


Lys Asn Gln Glu Gln Glu Glu Lys Ile Met Lys Leu Ser Asn Glu Ile 
        915                 920                 925             


Glu Thr Ala Thr Arg Ser Ile Thr Asn Asn Val Ser Gln Ile Lys Leu 
    930                 935                 940                 


Met His Thr Lys Ile Asp Glu Leu Arg Thr Leu Asp Ser Val Ser Gln 
945                 950                 955                 960 


Ile Ser Asn Ile Asp Leu Leu Asn Leu Arg Asp Leu Ser Asn Gly Ser 
                965                 970                 975     


Glu Glu Asp Asn Leu Pro Asn Thr Gln Leu Asp Leu Leu Gly Asn Asp 
            980                 985                 990         


Tyr Leu Val Ser Lys Gln Val Lys  Glu Tyr Arg Ile Gln  Glu Pro Asn 
        995                 1000                 1005             


Arg Glu  Asn Ser Phe His Ser  Ser Ile Glu Ala Ile  Trp Glu Glu 
    1010                 1015                 1020             


Cys Lys  Glu Ile Val Lys Ala  Ser Ser Lys Lys Ser  His Gln Ile 
    1025                 1030                 1035             


Glu Glu  Leu Glu Gln Gln Ile  Glu Lys Leu Gln Ala  Glu Val Lys 
    1040                 1045                 1050             


Gly Tyr  Lys Asp Glu Asn Asn  Arg Leu Lys Glu Lys  Glu His Lys 
    1055                 1060                 1065             


Asn Gln  Asp Asp Leu Leu Lys  Glu Lys Glu Thr Leu  Ile Gln Gln 
    1070                 1075                 1080             


Leu Lys  Glu Glu Leu Gln Glu  Lys Asn Val Thr Leu  Asp Val Gln 
    1085                 1090                 1095             


Ile Gln  His Val Val Glu Gly  Lys Arg Ala Leu Ser  Glu Leu Thr 
    1100                 1105                 1110             


Gln Gly  Val Thr Cys Tyr Lys  Ala Lys Ile Lys Glu  Leu Glu Thr 
    1115                 1120                 1125             


Ile Leu  Glu Thr Gln Lys Val  Glu Cys Ser His Ser  Ala Lys Leu 
    1130                 1135                 1140             


Glu Gln  Asp Ile Leu Glu Lys  Glu Ser Ile Ile Leu  Lys Leu Glu 
    1145                 1150                 1155             


Arg Asn  Leu Lys Glu Phe Gln  Glu His Leu Gln Asp  Ser Val Lys 
    1160                 1165                 1170             


Asn Thr  Lys Asp Leu Asn Val  Lys Glu Leu Lys Leu  Lys Glu Glu 
    1175                 1180                 1185             


Ile Thr  Gln Leu Thr Asn Asn  Leu Gln Asp Met Lys  His Leu Leu 
    1190                 1195                 1200             


Gln Leu  Lys Glu Glu Glu Glu  Glu Thr Asn Arg Gln  Glu Thr Glu 
    1205                 1210                 1215             


Lys Leu  Lys Glu Glu Leu Ser  Ala Ser Ser Ala Arg  Thr Gln Asn 
    1220                 1225                 1230             


Leu Lys  Ala Asp Leu Gln Arg  Lys Glu Glu Asp Tyr  Ala Asp Leu 
    1235                 1240                 1245             


Lys Glu  Lys Leu Thr Asp Ala  Lys Lys Gln Ile Lys  Gln Val Gln 
    1250                 1255                 1260             


Lys Glu  Val Ser Val Met Arg  Asp Glu Asp Lys Leu  Leu Arg Ile 
    1265                 1270                 1275             


Lys Ile  Asn Glu Leu Glu Lys  Lys Lys Asn Gln Cys  Ser Gln Glu 
    1280                 1285                 1290             


Leu Asp  Met Lys Gln Arg Thr  Ile Gln Gln Leu Lys  Glu Gln Leu 
    1295                 1300                 1305             


Asn Asn  Gln Lys Val Glu Glu  Ala Ile Gln Gln Tyr  Glu Arg Ala 
    1310                 1315                 1320             


Cys Lys  Asp Leu Asn Val Lys  Glu Lys Ile Ile Glu  Asp Met Arg 
    1325                 1330                 1335             


Met Thr  Leu Glu Glu Gln Glu  Gln Thr Gln Val Glu  Gln Asp Gln 
    1340                 1345                 1350             


Val Leu  Glu Ala Lys Leu Glu  Glu Val Glu Arg Leu  Ala Thr Glu 
    1355                 1360                 1365             


Leu Glu  Lys Trp Lys Glu Lys  Cys Asn Asp Leu Glu  Thr Lys Asn 
    1370                 1375                 1380             


Asn Gln  Arg Ser Asn Lys Glu  His Glu Asn Asn Thr  Asp Val Leu 
    1385                 1390                 1395             


Gly Lys  Leu Thr Asn Leu Gln  Asp Glu Leu Gln Glu  Ser Glu Gln 
    1400                 1405                 1410             


Lys Tyr  Asn Ala Asp Arg Lys  Lys Trp Leu Glu Glu  Lys Met Met 
    1415                 1420                 1425             


Leu Ile  Thr Gln Ala Lys Glu  Ala Glu Asn Ile Arg  Asn Lys Glu 
    1430                 1435                 1440             


Met Lys  Lys Tyr Ala Glu Asp  Arg Glu Arg Phe Phe  Lys Gln Gln 
    1445                 1450                 1455             


Asn Glu  Met Glu Ile Leu Thr  Ala Gln Leu Thr Glu  Lys Asp Ser 
    1460                 1465                 1470             


Asp Leu  Gln Lys Trp Arg Glu  Glu Arg Asp Gln Leu  Val Ala Ala 
    1475                 1480                 1485             


Leu Glu  Ile Gln Leu Lys Ala  Leu Ile Ser Ser Asn  Val Gln Lys 
    1490                 1495                 1500             


Asp Asn  Glu Ile Glu Gln Leu  Lys Arg Ile Ile Ser  Glu Thr Ser 
    1505                 1510                 1515             


Lys Ile  Glu Thr Gln Ile Met  Asp Ile Lys Pro Lys  Arg Ile Ser 
    1520                 1525                 1530             


Ser Ala  Asp Pro Asp Lys Leu  Gln Thr Glu Pro Leu  Ser Thr Ser 
    1535                 1540                 1545             


Phe Glu  Ile Ser Arg Asn Lys  Ile Glu Asp Gly Ser  Val Val Leu 
    1550                 1555                 1560             


Asp Ser  Cys Glu Val Ser Thr  Glu Asn Asp Gln Ser  Thr Arg Phe 
    1565                 1570                 1575             


Pro Lys  Pro Glu Leu Glu Ile  Gln Phe Thr Pro Leu  Gln Pro Asn 
    1580                 1585                 1590             


Lys Met  Ala Val Lys His Pro  Gly Cys Thr Thr Pro  Val Thr Val 
    1595                 1600                 1605             


Lys Ile  Pro Lys Ala Arg Lys  Arg Lys Ser Asn Glu  Met Glu Glu 
    1610                 1615                 1620             


Asp Leu  Val Lys Cys Glu Asn  Lys Lys Asn Ala Thr  Pro Arg Thr 
    1625                 1630                 1635             


Asn Leu  Lys Phe Pro Ile Ser  Asp Asp Arg Asn Ser  Ser Val Lys 
    1640                 1645                 1650             


Lys Glu  Gln Lys Val Ala Ile  Arg Pro Ser Ser Lys  Lys Thr Tyr 
    1655                 1660                 1665             


Ser Leu  Arg Ser Gln Ala Ser  Ile Ile Gly Val Asn  Leu Ala Thr 
    1670                 1675                 1680             


Lys Lys  Lys Glu Gly Thr Leu  Gln Lys Phe Gly Asp  Phe Leu Gln 
    1685                 1690                 1695             


His Ser  Pro Ser Ile Leu Gln  Ser Lys Ala Lys Lys  Ile Ile Glu 
    1700                 1705                 1710             


Thr Met  Ser Ser Ser Lys Leu  Ser Asn Val Glu Ala  Ser Lys Glu 
    1715                 1720                 1725             


Asn Val  Ser Gln Pro Lys Arg  Ala Lys Arg Lys Leu  Tyr Thr Ser 
    1730                 1735                 1740             


Glu Ile  Ser Ser Pro Ile Asp  Ile Ser Gly Gln Val  Ile Leu Met 
    1745                 1750                 1755             


Asp Gln  Lys Met Lys Glu Ser  Asp His Gln Ile Ile  Lys Arg Arg 
    1760                 1765                 1770             


Leu Arg  Thr Lys Thr Ala Lys  
    1775                 1780 


<210> 4886
<211> 456
<212> PRT
<213> Homo sapiens

<400> 4886
Met Asn Ser Ser Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu 
1               5                   10                  15      


Lys Glu Gln Ala Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln 
            20                  25                  30          


Lys Thr Lys Glu Lys Cys Asp Lys Ile Arg Gln Glu Arg Asp Glu Ala 
        35                  40                  45              


Val Lys Lys Leu Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu 
    50                  55                  60                  


Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg 
65                  70                  75                  80  


Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr 
                85                  90                  95      


Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val 
            100                 105                 110         


Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr 
        115                 120                 125             


Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile 
    130                 135                 140                 


Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Lys Leu Val Glu Val Ile 
                165                 170                 175     


Glu Glu Val Asn Lys Val Lys Gln Glu Lys Thr Val Leu Asn Ser Glu 
            180                 185                 190         


Val Leu Glu Gln Arg Lys Val Leu Glu Lys Cys Asn Arg Val Ser Met 
        195                 200                 205             


Leu Ala Val Glu Glu Tyr Glu Glu Met Gln Val Asn Leu Glu Leu Glu 
    210                 215                 220                 


Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala Gln Glu Met Phe Ile 
225                 230                 235                 240 


Glu Gln Asn Lys Leu Lys Arg Gln Ser His Leu Leu Leu Gln Ser Ser 
                245                 250                 255     


Ile Pro Asp Gln Gln Leu Leu Lys Ala Leu Asp Glu Asn Ala Lys Leu 
            260                 265                 270         


Thr Gln Gln Leu Glu Glu Glu Arg Ile Gln His Gln Gln Lys Val Lys 
        275                 280                 285             


Glu Leu Glu Glu Gln Leu Glu Asn Glu Thr Leu His Lys Glu Ile His 
    290                 295                 300                 


Asn Leu Lys Gln Gln Leu Glu Leu Leu Glu Glu Asp Lys Lys Glu Leu 
305                 310                 315                 320 


Glu Leu Lys Tyr Gln Asn Ser Glu Glu Lys Ala Arg Asn Leu Lys His 
                325                 330                 335     


Ser Val Asp Glu Leu Gln Lys Arg Val Asn Gln Ser Glu Asn Ser Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Asn 
        355                 360                 365             


Pro Ile Arg Ser Leu Met Ser Met Ile Arg Lys Arg Ser His Pro Ser 
    370                 375                 380                 


Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gln Pro Glu Thr Thr Glu 
385                 390                 395                 400 


Glu Val Thr Asp Leu Lys Arg Gln Ala Val Glu Glu Met Met Asp Arg 
                405                 410                 415     


Ile Lys Lys Gly Val His Leu Arg Pro Val Asn Gln Thr Ala Arg Pro 
            420                 425                 430         


Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser Ala Val Asp Glu 
        435                 440                 445             


Leu Lys Gly Ile Leu Ala Ser Gln 
    450                 455     


<210> 4887
<211> 209
<212> PRT
<213> Homo sapiens

<400> 4887
Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val 
1               5                   10                  15      


Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg 
            20                  25                  30          


Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp 
        35                  40                  45              


Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val 
    50                  55                  60                  


Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe 
65                  70                  75                  80  


Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu 
                85                  90                  95      


Phe Glu Leu Thr Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu 
            100                 105                 110         


Ser Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro 
        115                 120                 125             


Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr 
    130                 135                 140                 


Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser 
145                 150                 155                 160 


Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile 
                165                 170                 175     


Asp Ile Ile Ala Glu Leu Arg Tyr Asp Leu Pro Ala Ser Tyr Lys Phe 
            180                 185                 190         


His Lys Lys Lys Ser Val Asp Ile Glu Val Asp Leu Ile Arg Phe Ser 
        195                 200                 205             


Phe 
    


<210> 4888
<211> 1572
<212> PRT
<213> Homo sapiens

<400> 4888
Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met Glu Pro Glu Ile Lys Ile Cys Phe Lys Tyr Tyr His 
    130                 135                 140                 


Gly Ile Ser Gly Ala Leu Arg Ala Thr Thr Pro Cys Ile Thr Val Lys 
145                 150                 155                 160 


Asn Pro Ala Val Met Met Gly Ala Glu Gly Met Glu Gly Gly Ala Ser 
                165                 170                 175     


Gly Asn Leu His Ser Arg Lys Leu Val Ser Phe Thr Leu Ser Asp Leu 
            180                 185                 190         


Arg Ala Val Gly Leu Lys Lys Gly Met Phe Phe Asn Pro Asp Pro Tyr 
        195                 200                 205             


Leu Lys Met Ser Ile Gln Pro Gly Lys Lys Ser Ser Phe Pro Thr Cys 
    210                 215                 220                 


Ala His His Gly Gln Glu Arg Arg Ser Thr Ile Ile Ser Asn Thr Thr 
225                 230                 235                 240 


Asn Pro Ile Trp His Arg Glu Lys Tyr Ser Phe Phe Ala Leu Leu Thr 
                245                 250                 255     


Asp Val Leu Glu Ile Glu Ile Lys Asp Lys Phe Ala Lys Ser Arg Pro 
            260                 265                 270         


Ile Ile Lys Arg Phe Leu Gly Lys Leu Thr Ile Pro Val Gln Arg Leu 
        275                 280                 285             


Leu Glu Arg Gln Ala Ile Gly Asp Gln Met Leu Ser Tyr Asn Leu Gly 
    290                 295                 300                 


Arg Arg Leu Pro Ala Asp His Val Ser Gly Tyr Leu Gln Phe Lys Val 
305                 310                 315                 320 


Glu Val Thr Ser Ser Val His Glu Asp Ala Ser Pro Glu Ala Val Gly 
                325                 330                 335     


Thr Ile Leu Gly Val Asn Ser Val Asn Gly Asp Leu Gly Ser Pro Ser 
            340                 345                 350         


Asp Asp Glu Asp Met Pro Gly Ser His His Asp Ser Gln Val Cys Ser 
        355                 360                 365             


Asn Gly Pro Val Ser Glu Asp Ser Ala Ala Asp Gly Thr Pro Lys His 
    370                 375                 380                 


Ser Phe Arg Thr Ser Ser Thr Leu Glu Ile Asp Thr Glu Glu Leu Thr 
385                 390                 395                 400 


Ser Thr Ser Ser Arg Thr Ser Pro Pro Arg Gly Arg Gln Asp Ser Leu 
                405                 410                 415     


Asn Asp Tyr Leu Asp Ala Ile Glu His Asn Gly His Ser Arg Pro Gly 
            420                 425                 430         


Thr Ala Thr Cys Ser Glu Arg Ser Met Gly Ala Ser Pro Lys Leu Arg 
        435                 440                 445             


Ser Ser Phe Pro Thr Asp Thr Arg Leu Asn Ala Met Leu His Ile Asp 
    450                 455                 460                 


Ser Asp Glu Glu Asp His Glu Phe Gln Gln Asp Leu Gly Tyr Pro Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Glu Gly Gly Leu Ile Met Phe Ser Arg Ala Ser Arg 
                485                 490                 495     


Ala Asp Asp Gly Ser Leu Thr Ser Gln Thr Lys Leu Glu Asp Asn Pro 
            500                 505                 510         


Val Glu Asn Glu Glu Ala Ser Thr His Glu Ala Ala Ser Phe Glu Asp 
        515                 520                 525             


Lys Pro Glu Asn Leu Pro Glu Leu Ala Glu Ser Ser Leu Pro Ala Gly 
    530                 535                 540                 


Pro Ala Pro Glu Glu Gly Glu Gly Gly Pro Glu Pro Gln Pro Ser Ala 
545                 550                 555                 560 


Asp Gln Gly Ser Ala Glu Leu Cys Gly Ser Gln Glu Val Asp Gln Pro 
                565                 570                 575     


Thr Ser Gly Ala Asp Thr Gly Thr Ser Asp Ala Ser Gly Gly Ser Arg 
            580                 585                 590         


Arg Ala Val Ser Glu Thr Glu Ser Leu Asp Gln Gly Ser Glu Pro Ser 
        595                 600                 605             


Gln Val Ser Ser Glu Thr Glu Pro Ser Asp Pro Ala Arg Thr Glu Ser 
    610                 615                 620                 


Val Ser Glu Ala Ser Thr Arg Pro Glu Gly Glu Ser Asp Leu Glu Cys 
625                 630                 635                 640 


Ala Asp Ser Ser Cys Asn Glu Ser Val Thr Thr Gln Leu Ser Ser Val 
                645                 650                 655     


Asp Thr Arg Cys Ser Ser Leu Glu Ser Ala Arg Phe Pro Glu Thr Pro 
            660                 665                 670         


Ala Phe Ser Ser Gln Glu Glu Glu Asp Gly Ala Cys Ala Ala Glu Pro 
        675                 680                 685             


Thr Ser Ser Gly Pro Ala Glu Gly Ser Gln Glu Ser Val Cys Thr Ala 
    690                 695                 700                 


Gly Ser Leu Pro Val Val Gln Val Pro Ser Gly Glu Asp Glu Gly Pro 
705                 710                 715                 720 


Gly Ala Glu Ser Ala Thr Val Pro Asp Gln Glu Glu Leu Gly Glu Val 
                725                 730                 735     


Trp Gln Arg Arg Gly Ser Leu Glu Gly Ala Ala Ala Ala Ala Glu Ser 
            740                 745                 750         


Pro Pro Gln Glu Glu Gly Ser Ala Gly Glu Ala Gln Gly Thr Cys Glu 
        755                 760                 765             


Gly Ala Thr Ala Gln Glu Glu Gly Ala Thr Gly Gly Ser Gln Ala Asn 
    770                 775                 780                 


Gly His Gln Pro Leu Arg Ser Leu Pro Ser Val Arg Gln Asp Val Ser 
785                 790                 795                 800 


Arg Tyr Gln Arg Val Asp Glu Ala Leu Pro Pro Asn Trp Glu Ala Arg 
                805                 810                 815     


Ile Asp Ser His Gly Arg Ile Phe Tyr Val Asp His Val Asn Arg Thr 
            820                 825                 830         


Thr Thr Trp Gln Arg Pro Thr Ala Pro Pro Ala Pro Gln Val Leu Gln 
        835                 840                 845             


Arg Ser Asn Ser Ile Gln Gln Met Glu Gln Leu Asn Arg Arg Tyr Gln 
    850                 855                 860                 


Ser Ile Arg Arg Thr Met Thr Asn Glu Arg Pro Glu Glu Asn Thr Asn 
865                 870                 875                 880 


Ala Ile Asp Gly Ala Gly Glu Glu Ala Asp Phe His Gln Ala Ser Ala 
                885                 890                 895     


Asp Phe Arg Arg Glu Asn Ile Leu Pro His Ser Thr Ser Arg Ser Arg 
            900                 905                 910         


Ile Thr Leu Leu Leu Gln Ser Pro Pro Val Lys Phe Leu Ile Ser Pro 
        915                 920                 925             


Glu Phe Phe Thr Val Leu His Ser Asn Pro Ser Ala Tyr Arg Met Phe 
    930                 935                 940                 


Thr Asn Asn Thr Cys Leu Lys His Met Ile Thr Lys Val Arg Arg Asp 
945                 950                 955                 960 


Thr His His Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Gly Phe 
                965                 970                 975     


Leu Asn Met Phe Ala Asn Lys Gln Leu Glu Leu Pro Arg Gly Trp Glu 
            980                 985                 990         


Met Lys His Asp His Gln Gly Lys  Ala Phe Phe Val Asp  His Asn Ser 
        995                 1000                 1005             


Arg Thr  Thr Thr Phe Ile Asp  Pro Arg Leu Pro Leu  Gln Ser Ser 
    1010                 1015                 1020             


Arg Pro  Thr Ser Ala Leu Val  His Arg Gln His Leu  Thr Arg Gln 
    1025                 1030                 1035             


Arg Ser  His Ser Ala Gly Glu  Val Gly Glu Asp Ser  Arg His Ala 
    1040                 1045                 1050             


Gly Pro  Pro Val Leu Pro Arg  Pro Ser Ser Thr Phe  Asn Thr Val 
    1055                 1060                 1065             


Ser Arg  Pro Gln Tyr Gln Asp  Met Val Pro Val Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Ile Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Asp Leu  Thr Arg Asn His Ser  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Gln Phe Ile Arg Thr  Glu Gly Thr Pro Gly  Leu Val Arg 
    1115                 1120                 1125             


Leu Ser  Ser Asp Ala Asp Leu  Val Met Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Pro His Ala Leu  Leu His Pro 
    1145                 1150                 1155             


Ser Tyr  Cys Gln Ser Pro Arg  Gly Ser Pro Val Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Thr Gln Arg  Ala Asn Ala Arg Ala  Pro Ala Pro 
    1175                 1180                 1185             


Tyr Lys  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Thr Lys Gly Tyr Gly  Gln Gly Pro Gly Lys  Leu Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Asp Ala Phe  Asn Gln Ile 
    1220                 1225                 1230             


Met Gly  Tyr Ser Arg Lys Asp  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Val Ser  Arg Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Asp Asn His His Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Ile Leu  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asp Ile  His Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Ile 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Pro  Gly Gly Ala Asn Ile  Pro Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Val Val Gln  Gln Thr Glu Ser Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ala  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Ser Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Asn His  Ile Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Ile Pro Tyr Glu Gly  Phe Ala Ser Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Pro  Arg Arg Phe Cys Val  Glu Lys Trp Gly Lys  Ile Thr Ala 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Phe Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         


<210> 4889
<211> 401
<212> PRT
<213> Homo sapiens

<400> 4889
Met Ser Cys Arg Cys Trp Ile Ser Arg His Pro Ser Tyr Glu Gly Trp 
1               5                   10                  15      


Asn Leu Gln Ser Ile Ile Phe His Lys Gln Ile Arg Gly Val Asp Leu 
            20                  25                  30          


Glu Ser Thr Phe Val Thr Lys Phe Gly Asn Asn Cys Ser Leu Arg Leu 
        35                  40                  45              


Asn Glu Thr Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile 
    50                  55                  60                  


Gly Ile Leu Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile 
65                  70                  75                  80  


Ala Pro Ala Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile 
                85                  90                  95      


Asp Tyr Thr Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Thr 
            100                 105                 110         


Gln Asn Met Lys Met Gly Gly Leu Pro Arg Thr Thr Pro Pro Thr Gln 
        115                 120                 125             


Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Thr Leu Gly Arg His 
    130                 135                 140                 


Ser Pro Tyr Arg Thr Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn 
145                 150                 155                 160 


Asp Tyr Val Pro Ser Pro Thr Arg Asn Met Ala Pro Ser Gln Gln Ser 
                165                 170                 175     


Pro Val Arg Thr Ala Ser Val Asn Gln Arg Asn Arg Thr Tyr Ser Ser 
            180                 185                 190         


Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg 
        195                 200                 205             


Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Thr 
    210                 215                 220                 


Pro Ser Pro Pro Ser Val Phe Pro Gly His Pro Val Gln Phe Tyr Ser 
225                 230                 235                 240 


Met Asn Arg Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser 
                245                 250                 255     


Leu Pro Tyr Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln 
            260                 265                 270         


Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp 
        275                 280                 285             


Thr Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala 
305                 310                 315                 320 


Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala 
                325                 330                 335     


Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys 
            340                 345                 350         


Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val 
        355                 360                 365             


Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Met Asn Gly Val 
    370                 375                 380                 


Thr Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Ser 
385                 390                 395                 400 


Glu 
    


<210> 4890
<211> 475
<212> PRT
<213> Homo sapiens

<400> 4890
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Thr Gln Asn Met 
145                 150                 155                 160 


Lys Met Gly Gly Leu Pro Arg Thr Thr Pro Pro Thr Gln Lys Pro Pro 
                165                 170                 175     


Ser Pro Pro Met Ser Gly Lys Gly Thr Leu Gly Arg His Ser Pro Tyr 
            180                 185                 190         


Arg Thr Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn Asp Tyr Val 
        195                 200                 205             


Pro Ser Pro Thr Arg Asn Met Ala Pro Ser Gln Gln Ser Pro Val Arg 
    210                 215                 220                 


Thr Ala Ser Val Asn Gln Arg Asn Arg Thr Tyr Ser Ser Ser Gly Ser 
225                 230                 235                 240 


Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Thr Pro Ser Pro 
            260                 265                 270         


Pro Ser Val Phe Pro Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg 
        275                 280                 285             


Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser Leu Pro Tyr 
    290                 295                 300                 


Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln Asn Gln Met 
305                 310                 315                 320 


Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Leu Ala Pro Pro 
                325                 330                 335     


Pro Pro Ser Ile Leu Gln Val Thr Pro Gln Leu Pro Leu Met Gly Phe 
            340                 345                 350         


Val Ala Arg Val Gln Glu Asn Ile Ser Asp Thr Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp 
385                 390                 395                 400 


Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu 
                405                 410                 415     


Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp Lys Glu Asp Glu Leu 
            420                 425                 430         


Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
        435                 440                 445             


Gly Trp Tyr Glu Gly Val Met Asn Gly Val Thr Gly Leu Phe Pro Gly 
    450                 455                 460                 


Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
465                 470                 475 


<210> 4891
<211> 299
<212> PRT
<213> Homo sapiens

<400> 4891
Met Lys Met Gly Gly Leu Pro Arg Thr Thr Pro Pro Thr Gln Lys Pro 
1               5                   10                  15      


Pro Ser Pro Pro Met Ser Gly Lys Gly Thr Leu Gly Ser Ser Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser 
        35                  40                  45              


Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Thr Pro Ser Pro 
    50                  55                  60                  


Pro Ser Val Phe Pro Ala Pro Ala Gly Ser Ala Gly Thr Pro Pro Leu 
65                  70                  75                  80  


Pro Ala Thr Ser Ala Ser Ala Pro Ala Pro Leu Val Pro Ala Thr Val 
                85                  90                  95      


Pro Ser Ser Thr Ala Pro Asp Ala Ala Ala Gly Gly Ala Gln Thr Leu 
            100                 105                 110         


Ala Asp Gly Phe Thr Ser Pro Thr Pro Pro Val Val Ser Ser Thr Pro 
        115                 120                 125             


Pro Thr Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser 
    130                 135                 140                 


Arg His Thr Pro Pro Thr Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro 
145                 150                 155                 160 


Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln Asn Gln Met Asn Gly Gly 
                165                 170                 175     


Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp Thr Pro Pro Pro Pro Pro 
            180                 185                 190         


Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro 
        195                 200                 205             


Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp 
    210                 215                 220                 


Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu 
225                 230                 235                 240 


Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp Lys Glu Asp Glu Leu 
                245                 250                 255     


Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
            260                 265                 270         


Gly Trp Tyr Glu Gly Val Met Asn Gly Val Thr Gly Leu Phe Pro Gly 
        275                 280                 285             


Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
    290                 295                 


<210> 4892
<211> 641
<212> PRT
<213> Homo sapiens

<400> 4892
Met Gly Arg Arg Ser Thr Ser Ser Thr Lys Ser Gly Lys Phe Met Asn 
1               5                   10                  15      


Pro Thr Asp Gln Ala Arg Lys Glu Ala Arg Lys Arg Glu Leu Lys Lys 
            20                  25                  30          


Asn Lys Lys Gln Arg Met Met Val Arg Ala Ala Val Leu Lys Met Lys 
        35                  40                  45              


Asp Pro Lys Gln Ile Ile Arg Asp Met Glu Lys Leu Asp Glu Met Glu 
    50                  55                  60                  


Phe Asn Pro Val Gln Gln Pro Gln Leu Asn Glu Lys Val Leu Lys Asp 
65                  70                  75                  80  


Lys Arg Lys Lys Leu Arg Glu Thr Phe Glu Arg Ile Leu Arg Leu Tyr 
                85                  90                  95      


Glu Lys Glu Asn Pro Asp Ile Tyr Lys Glu Leu Arg Lys Leu Glu Val 
            100                 105                 110         


Glu Tyr Glu Gln Lys Arg Ala Gln Leu Ser Gln Tyr Phe Asp Ala Val 
        115                 120                 125             


Lys Asn Ala Gln His Val Glu Val Glu Ser Ile Pro Leu Pro Asp Met 
    130                 135                 140                 


Pro His Ala Pro Ser Asn Ile Leu Ile Gln Asp Ile Pro Leu Pro Gly 
145                 150                 155                 160 


Ala Gln Pro Pro Ser Ile Leu Lys Lys Thr Ser Ala Tyr Gly Pro Pro 
                165                 170                 175     


Thr Arg Ala Val Ser Ile Leu Pro Leu Leu Gly His Gly Val Pro Arg 
            180                 185                 190         


Leu Pro Pro Gly Arg Lys Pro Pro Gly Pro Pro Pro Gly Pro Pro Pro 
        195                 200                 205             


Pro Gln Val Val Gln Met Tyr Gly Arg Lys Val Gly Phe Ala Leu Asp 
    210                 215                 220                 


Leu Pro Pro Arg Arg Arg Asp Glu Asp Met Leu Tyr Ser Pro Glu Leu 
225                 230                 235                 240 


Ala Gln Arg Gly His Asp Asp Asp Val Ser Ser Thr Ser Glu Asp Asp 
                245                 250                 255     


Gly Tyr Pro Glu Asp Met Asp Gln Asp Lys His Asp Asp Ser Thr Asp 
            260                 265                 270         


Asp Ser Asp Thr Asp Lys Ser Asp Gly Glu Ser Asp Gly Asp Glu Phe 
        275                 280                 285             


Val His Arg Asp Asn Gly Glu Arg Asp Asn Asn Glu Glu Lys Lys Ser 
    290                 295                 300                 


Gly Leu Ser Val Arg Phe Ala Asp Met Pro Gly Lys Ser Arg Lys Lys 
305                 310                 315                 320 


Lys Lys Asn Met Lys Glu Leu Thr Pro Leu Gln Ala Met Met Leu Arg 
                325                 330                 335     


Met Ala Gly Gln Glu Ile Pro Glu Glu Gly Arg Glu Val Glu Glu Phe 
            340                 345                 350         


Ser Glu Asp Asp Asp Glu Asp Asp Ser Asp Asp Ser Glu Ala Glu Lys 
        355                 360                 365             


Gln Ser Gln Lys Gln His Lys Glu Glu Ser His Ser Asp Gly Thr Ser 
    370                 375                 380                 


Thr Ala Ser Ser Gln Gln Gln Ala Pro Pro Gln Ser Val Pro Pro Ser 
385                 390                 395                 400 


Gln Ile Gln Ala Pro Pro Met Pro Gly Pro Pro Pro Leu Gly Pro Pro 
                405                 410                 415     


Pro Ala Pro Pro Leu Arg Pro Pro Gly Pro Pro Thr Gly Leu Pro Pro 
            420                 425                 430         


Gly Pro Pro Pro Gly Ala Pro Pro Phe Leu Arg Pro Pro Gly Met Pro 
        435                 440                 445             


Gly Leu Arg Gly Pro Leu Pro Arg Leu Leu Pro Pro Gly Pro Pro Pro 
    450                 455                 460                 


Gly Arg Pro Pro Gly Pro Pro Pro Gly Pro Pro Pro Gly Leu Pro Pro 
465                 470                 475                 480 


Gly Pro Pro Pro Arg Gly Pro Pro Pro Arg Leu Pro Pro Pro Ala Pro 
                485                 490                 495     


Pro Gly Ile Pro Pro Pro Arg Pro Gly Met Met Arg Pro Pro Leu Val 
            500                 505                 510         


Pro Pro Leu Gly Pro Ala Pro Pro Gly Leu Phe Pro Pro Ala Pro Leu 
        515                 520                 525             


Pro Asn Pro Gly Val Leu Ser Ala Pro Pro Asn Leu Ile Gln Arg Pro 
    530                 535                 540                 


Lys Ala Asp Asp Thr Ser Ala Ala Thr Ile Glu Lys Lys Ala Thr Ala 
545                 550                 555                 560 


Thr Ile Ser Ala Lys Pro Gln Ile Thr Asn Pro Lys Ala Glu Ile Thr 
                565                 570                 575     


Arg Phe Val Pro Thr Ala Leu Arg Val Arg Arg Glu Asn Lys Gly Ala 
            580                 585                 590         


Thr Ala Ala Pro Gln Arg Lys Ser Glu Asp Asp Ser Ala Val Pro Leu 
        595                 600                 605             


Ala Lys Ala Ala Pro Lys Ser Gly Pro Ser Val Pro Val Ser Val Gln 
    610                 615                 620                 


Thr Lys Asp Asp Val Tyr Glu Ala Phe Met Lys Glu Met Glu Gly Leu 
625                 630                 635                 640 


Leu 
    


<210> 4893
<211> 1472
<212> PRT
<213> Homo sapiens

<400> 4893
Met Lys Gly Ser Glu Val Ser Leu Glu Lys Lys Lys Lys Ile Lys Met 
1               5                   10                  15      


Pro Val Lys Arg Leu Arg Glu Val Val Ser Gln Asn His Gly Asp His 
            20                  25                  30          


Leu Val Leu Leu Lys Asp Glu Leu Pro Cys Val Pro Pro Ala Leu Ser 
        35                  40                  45              


Ala Asn Lys Arg Leu Pro Val Gly Thr Gly Thr Ser Leu Asn Gly Thr 
    50                  55                  60                  


Ser Arg Gly Ser Ser Asp Leu Thr Ser Ala Arg Asn Cys Tyr Gln Pro 
65                  70                  75                  80  


Leu Leu Glu Asn Pro Met Val Ser Glu Ser Asp Phe Ser Lys Asp Val 
                85                  90                  95      


Ala Val Gln Val Leu Pro Leu Asp Lys Ile Glu Glu Asn Asn Lys Gln 
            100                 105                 110         


Lys Ala Asn Asp Ile Phe Ile Ser Gln Tyr Thr Met Gly Gln Lys Asp 
        115                 120                 125             


Ala Leu Arg Thr Val Leu Lys Gln Lys Ala Gln Ser Met Pro Val Phe 
    130                 135                 140                 


Lys Glu Val Lys Val His Leu Leu Glu Asp Ala Gly Ile Glu Lys Asp 
145                 150                 155                 160 


Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser Gly Ile Asp Ser Ala 
                165                 170                 175     


Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile Ala Thr Ala Ala Pro 
            180                 185                 190         


Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys Val Asn Ser Val Thr 
        195                 200                 205             


Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys His Leu Gln Arg Val 
    210                 215                 220                 


Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln Glu Lys Leu His Cys 
225                 230                 235                 240 


His Asp His Glu Lys Gln Met Asn Val Phe Met Glu Gln His Ile Arg 
                245                 250                 255     


His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp Ile Gln Thr His Phe 
            260                 265                 270         


Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln Pro Val Ser Met Pro 
        275                 280                 285             


Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys Pro Glu His Pro Asn 
    290                 295                 300                 


Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr Phe Ala Ser Lys Gln 
305                 310                 315                 320 


Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe Asp Lys Gln Lys Ser 
                325                 330                 335     


Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala Pro Val Pro Val Ser 
            340                 345                 350         


Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu Leu Glu Glu Lys Glu 
        355                 360                 365             


Asn Met Glu Val Ser Cys His Arg Gly Asn Val Arg Leu Leu Glu Gln 
    370                 375                 380                 


Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys Ser Glu Ser Ser Asn 
385                 390                 395                 400 


Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp Thr Pro Glu Lys Thr 
                405                 410                 415     


Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr Thr Lys Val Thr Met 
            420                 425                 430         


Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly Gln Lys Glu Lys Glu 
        435                 440                 445             


Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu Ser Met Leu Lys Leu 
    450                 455                 460                 


Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln Thr Thr Asn Thr Thr 
465                 470                 475                 480 


Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu Arg Gly Val Gln Asn 
                485                 490                 495     


Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala Ile Ile Arg Ala Lys 
            500                 505                 510         


Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala Leu Ser Thr Asn Arg 
        515                 520                 525             


Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr Val Asp Glu Trp Ile 
    530                 535                 540                 


Lys Thr Ile Ser Ala Glu Ile Gln Gly Leu Leu Lys Ala Thr Thr Val 
545                 550                 555                 560 


Ile Gln Asp Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val Tyr 
                565                 570                 575     


Gln Gly His Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe Asn 
            580                 585                 590         


Ser Pro Ser Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu Arg 
        595                 600                 605             


Val Lys Gly Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe Tyr 
    610                 615                 620                 


Ala Thr Lys Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val Pro 
625                 630                 635                 640 


Val Leu Pro His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg Glu 
                645                 650                 655     


Met Pro Thr Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met Ala 
            660                 665                 670         


Ile Leu Leu Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro Ala 
        675                 680                 685             


Gly Val Ile Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser Ile 
    690                 695                 700                 


Pro Pro Ser Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn Ile 
705                 710                 715                 720 


Ala Ile Val Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu Thr 
                725                 730                 735     


Val Gln Val Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser Ser 
            740                 745                 750         


Ala Asp Val Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Leu Pro 
        755                 760                 765             


Pro Val Gln Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp Glu 
    770                 775                 780                 


Glu Glu Val Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp Val 
785                 790                 795                 800 


Ile Gln Glu Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro Ile 
                805                 810                 815     


Leu Glu Phe Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn Gly 
            820                 825                 830         


Pro Pro Phe Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp Ile 
        835                 840                 845             


Leu Asp Lys Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu Ile 
    850                 855                 860                 


Gln Trp Val Glu Gln Glu Ile Met Ser Arg Ile Ile Ser Gly Leu Phe 
865                 870                 875                 880 


Pro Val Gln Gln Gln Ile Ala Pro Ser Ile Ser Val Ser Val Ser Glu 
                885                 890                 895     


Thr Ser Glu Pro Leu Thr Ser Asp Ile Val Glu Gly Thr Ser Ser Gly 
            900                 905                 910         


Ala Leu Gln Leu Phe Val Asp Ala Gly Val Pro Val Asn Ser Asn Val 
        915                 920                 925             


Ile Lys His Phe Val Asn Glu Ala Leu Ala Glu Thr Ile Ala Val Met 
    930                 935                 940                 


Leu Gly Asp Arg Glu Ala Lys Lys Gln Gly Pro Val Ala Thr Gly Val 
945                 950                 955                 960 


Ser Gly Asp Ala Ser Thr Asn Glu Thr Tyr Leu Pro Ala Arg Val Cys 
                965                 970                 975     


Thr Pro Leu Pro Thr Pro Gln Pro Thr Pro Pro Cys Ser Pro Ser Ser 
            980                 985                 990         


Pro Ala Lys Glu Cys Val Leu Val  Lys Thr Pro Asp Ser  Ser Pro Cys 
        995                 1000                 1005             


Asp Ser  Asp His Asp Met Ala  Phe Pro Val Lys Glu  Ile Cys Ala 
    1010                 1015                 1020             


Glu Lys  Gly Asp Asp Met Pro  Ala Ile Met Leu Val  Asn Thr Pro 
    1025                 1030                 1035             


Thr Val  Thr Pro Thr Thr Thr  Pro Pro Pro Ala Ala  Ala Val Phe 
    1040                 1045                 1050             


Thr Pro  Thr Leu Ser Asp Ile  Ser Ile Asp Lys Leu  Lys Val Ser 
    1055                 1060                 1065             


Ser Pro  Glu Leu Pro Lys Pro  Trp Gly Asp Gly Asp  Leu Pro Leu 
    1070                 1075                 1080             


Glu Glu  Glu Asn Pro Asn Ser  Pro Gln Glu Glu Leu  His Pro Arg 
    1085                 1090                 1095             


Ala Ile  Val Met Ser Val Ala  Lys Asp Glu Glu Pro  Glu Ser Met 
    1100                 1105                 1110             


Asp Phe  Pro Ala Gln Pro Pro  Pro Pro Glu Pro Val  Pro Phe Met 
    1115                 1120                 1125             


Pro Phe  Pro Ala Gly Thr Lys  Ala Pro Ser Pro Ser  Gln Met Pro 
    1130                 1135                 1140             


Gly Ser  Asp Ser Ser Thr Leu  Glu Ser Thr Leu Ser  Val Thr Val 
    1145                 1150                 1155             


Thr Glu  Thr Glu Thr Leu Asp  Lys Pro Ile Ser Glu  Gly Glu Ile 
    1160                 1165                 1170             


Leu Phe  Ser Cys Gly Gln Lys  Leu Ala Pro Lys Ile  Leu Glu Asp 
    1175                 1180                 1185             


Ile Gly  Leu Tyr Leu Thr Asn  Leu Asn Asp Ser Leu  Ser Ser Thr 
    1190                 1195                 1200             


Leu His  Asp Ala Val Glu Met  Glu Asp Asp Pro Pro  Ser Glu Gly 
    1205                 1210                 1215             


Gln Val  Ile Arg Met Ser His  Lys Lys Phe His Ala  Asp Ala Ile 
    1220                 1225                 1230             


Leu Ser  Phe Ala Lys Gln Asn  Gln Glu Ser Ala Val  Ser Gln Gln 
    1235                 1240                 1245             


Ala Val  Tyr His Ser Glu Asp  Leu Glu Asn Ser Val  Gly Glu Leu 
    1250                 1255                 1260             


Ser Glu  Gly Gln Arg Pro Gln  Leu Thr Ala Ala Ala  Glu Asn Ile 
    1265                 1270                 1275             


Leu Met  Gly His Ser Leu Tyr  Met Gln Pro Pro Val  Thr Asn Thr 
    1280                 1285                 1290             


Gln Ser  Leu Asp Gln Gln Cys  Asp Pro Lys Pro Leu  Ser Arg Gln 
    1295                 1300                 1305             


Phe Asp  Thr Val Ser Gly Ser  Ile Tyr Glu Asp Ser  Cys Ala Ser 
    1310                 1315                 1320             


His Gly  Pro Met Ser Leu Gly  Glu Leu Glu Leu Glu  Pro Asn Ser 
    1325                 1330                 1335             


Lys Leu  Val Leu Pro Thr Thr  Leu Leu Thr Ala Gln  Glu Asn Asp 
    1340                 1345                 1350             


Val Asn  Leu Pro Val Ala Ala  Glu Asp Phe Ser Gln  Tyr Gln Leu 
    1355                 1360                 1365             


Lys Gln  Asn Gln Asp Val Lys  Gln Val Glu His Lys  Pro Ser Gln 
    1370                 1375                 1380             


Ser Tyr  Leu Arg Val Arg Asn  Lys Ser Asp Ile Ala  Pro Ser Gln 
    1385                 1390                 1395             


Gln Gln  Val Ser Pro Gly Asp  Met Asp Arg Thr Gln  Ile Glu Leu 
    1400                 1405                 1410             


Asn Pro  Tyr Leu Thr Cys Val  Phe Ser Gly Gly Lys  Ala Val Pro 
    1415                 1420                 1425             


Leu Ser  Ala Ser Gln Met Pro  Pro Ala Lys Met Ser  Val Met Leu 
    1430                 1435                 1440             


Pro Ser  Val Asn Leu Glu Asp  Cys Ser Gln Ser Leu  Ser Leu Ser 
    1445                 1450                 1455             


Thr Met  Gln Glu Asp Met Glu  Ser Ser Gly Ala Asp  Thr Phe 
    1460                 1465                 1470         


<210> 4894
<211> 661
<212> PRT
<213> Homo sapiens

<400> 4894
Met Glu Gly Ala Ala Ala Pro Val Ala Gly Asp Arg Pro Asp Leu Gly 
1               5                   10                  15      


Leu Gly Ala Pro Gly Ser Pro Arg Glu Ala Val Ala Gly Ala Thr Ala 
            20                  25                  30          


Ala Leu Glu Pro Arg Lys Pro His Gly Val Lys Arg His His His Lys 
        35                  40                  45              


His Asn Leu Lys His Arg Tyr Glu Leu Gln Glu Thr Leu Gly Lys Gly 
    50                  55                  60                  


Thr Tyr Gly Lys Val Lys Arg Ala Thr Glu Arg Phe Ser Gly Arg Val 
65                  70                  75                  80  


Val Ala Ile Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu Gln Asp 
                85                  90                  95      


Met Val His Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu Asn His 
            100                 105                 110         


Pro His Ile Ile Ser Ile Tyr Glu Val Phe Glu Asn Lys Asp Lys Ile 
        115                 120                 125             


Val Ile Ile Met Glu Tyr Ala Ser Lys Gly Glu Leu Tyr Asp Tyr Ile 
    130                 135                 140                 


Ser Glu Arg Arg Arg Leu Ser Glu Arg Glu Thr Arg His Phe Phe Arg 
145                 150                 155                 160 


Gln Ile Val Ser Ala Val His Tyr Cys His Lys Asn Gly Val Val His 
                165                 170                 175     


Arg Asp Leu Lys Leu Glu Asn Ile Leu Leu Asp Asp Asn Cys Asn Ile 
            180                 185                 190         


Lys Ile Ala Asp Phe Gly Leu Ser Asn Leu Tyr Gln Lys Asp Lys Phe 
        195                 200                 205             


Leu Gln Thr Phe Cys Gly Ser Pro Leu Tyr Ala Ser Pro Glu Ile Val 
    210                 215                 220                 


Asn Gly Arg Pro Tyr Arg Gly Pro Glu Val Asp Ser Trp Ala Leu Gly 
225                 230                 235                 240 


Val Leu Leu Tyr Thr Leu Val Tyr Gly Thr Met Pro Phe Asp Gly Phe 
                245                 250                 255     


Asp His Lys Asn Leu Ile Arg Gln Ile Ser Ser Gly Glu Tyr Arg Glu 
            260                 265                 270         


Pro Thr Gln Pro Ser Asp Ala Arg Gly Leu Ile Arg Trp Met Leu Met 
        275                 280                 285             


Val Asn Pro Asp Arg Arg Ala Thr Ile Glu Asp Ile Ala Asn His Trp 
    290                 295                 300                 


Trp Val Asn Trp Gly Tyr Lys Ser Ser Val Cys Asp Cys Asp Ala Leu 
305                 310                 315                 320 


His Asp Ser Glu Ser Pro Leu Leu Ala Arg Ile Ile Asp Trp His His 
                325                 330                 335     


Arg Ser Thr Gly Leu Gln Ala Asp Thr Glu Ala Lys Met Lys Gly Leu 
            340                 345                 350         


Ala Lys Pro Thr Thr Ser Glu Val Met Leu Glu Arg Gln Arg Ser Leu 
        355                 360                 365             


Lys Lys Ser Lys Lys Glu Asn Asp Phe Ala Gln Ser Gly Gln Asp Ala 
    370                 375                 380                 


Val Pro Glu Ser Pro Ser Lys Leu Ser Ser Lys Arg Pro Lys Gly Ile 
385                 390                 395                 400 


Leu Lys Lys Arg Ser Asn Ser Glu His Arg Ser His Ser Thr Gly Phe 
                405                 410                 415     


Ile Glu Gly Val Val Gly Pro Ala Leu Pro Ser Thr Phe Lys Met Glu 
            420                 425                 430         


Gln Asp Leu Cys Arg Thr Gly Val Leu Leu Pro Ser Ser Pro Glu Ala 
        435                 440                 445             


Glu Val Pro Gly Lys Leu Ser Pro Lys Gln Ser Ala Thr Met Pro Lys 
    450                 455                 460                 


Lys Gly Ile Leu Lys Lys Thr Gln Gln Arg Glu Ser Gly Tyr Tyr Ser 
465                 470                 475                 480 


Ser Pro Glu Arg Ser Glu Ser Ser Glu Leu Leu Asp Ser Asn Asp Val 
                485                 490                 495     


Met Gly Ser Ser Ile Pro Ser Pro Ser Pro Pro Asp Pro Ala Arg Val 
            500                 505                 510         


Thr Ser His Ser Leu Ser Cys Arg Arg Lys Gly Ile Leu Lys His Ser 
        515                 520                 525             


Ser Lys Tyr Ser Ala Gly Thr Met Asp Pro Ala Leu Val Ser Pro Glu 
    530                 535                 540                 


Met Pro Thr Leu Glu Ser Leu Ser Glu Pro Gly Val Pro Ala Glu Gly 
545                 550                 555                 560 


Leu Ser Arg Ser Tyr Ser Arg Pro Ser Ser Val Ile Ser Asp Asp Ser 
                565                 570                 575     


Val Leu Ser Ser Asp Ser Phe Asp Leu Leu Asp Leu Gln Glu Asn Arg 
            580                 585                 590         


Pro Ala Arg Gln Arg Ile Arg Ser Cys Val Ser Ala Glu Asn Phe Leu 
        595                 600                 605             


Gln Ile Gln Asp Phe Glu Gly Leu Gln Asn Arg Pro Arg Pro Gln Tyr 
    610                 615                 620                 


Leu Lys Arg Tyr Arg Asn Arg Leu Ala Asp Ser Ser Phe Ser Leu Leu 
625                 630                 635                 640 


Thr Asp Met Asp Asp Val Thr Gln Val Tyr Lys Gln Ala Leu Glu Ile 
                645                 650                 655     


Cys Ser Lys Leu Asn 
            660     


<210> 4895
<211> 200
<212> PRT
<213> Homo sapiens

<400> 4895
Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      


Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val 
            20                  25                  30          


Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp 
        35                  40                  45              


Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu 
    50                  55                  60                  


Thr Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp 
65                  70                  75                  80  


His Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu 
                85                  90                  95      


Lys Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser 
            100                 105                 110         


Leu Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala 
        115                 120                 125             


Val Val Ala Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr 
    130                 135                 140                 


Ala Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro 
145                 150                 155                 160 


Glu Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg 
                165                 170                 175     


Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr 
            180                 185                 190         


Ala Thr Glu Leu Leu Leu Ser Asn 
        195                 200 


<210> 4896
<211> 1770
<212> PRT
<213> Homo sapiens

<400> 4896
Met Pro Arg Arg Arg Lys Asn Leu Gly Gly Asn Pro Phe Arg Lys Thr 
1               5                   10                  15      


Ala Asn Pro Lys Glu Val Val Val Ser Ser Val Ala Ser Arg Glu Glu 
            20                  25                  30          


Pro Thr Thr Thr Leu Pro Ser Met Gly Glu Thr Lys Val Asp Gln Glu 
        35                  40                  45              


Glu Leu Phe Thr Ser Ile Ser Glu Ile Phe Ser Asp Leu Asp Pro Asp 
    50                  55                  60                  


Val Val Tyr Leu Met Leu Ser Glu Cys Asp Phe Lys Val Glu Asn Ala 
65                  70                  75                  80  


Met Asp Cys Leu Leu Glu Leu Ser Ala Thr Asp Thr Lys Ile Glu Glu 
                85                  90                  95      


Ser Ser Ser Gln Ser Phe Val Ala Ser Glu Asn Gln Val Gly Ala Ala 
            100                 105                 110         


Glu Ser Lys Ile Met Glu Lys Arg Pro Glu Glu Glu Ser Glu Asp Ser 
        115                 120                 125             


Lys Met Asp Ser Phe Leu Asp Met Gln Leu Thr Glu Asp Leu Asp Ser 
    130                 135                 140                 


Leu Ile Gln Asn Ala Phe Glu Lys Leu Asn Ser Ser Pro Asp Asp Gln 
145                 150                 155                 160 


Val Tyr Ser Phe Leu Pro Ser Gln Asp Val Asn Ser Phe Asn Asp Ser 
                165                 170                 175     


Ser Glu Phe Ile Asn Pro Asp Ser Ser Asn Met Thr Pro Ile Phe Ser 
            180                 185                 190         


Thr Gln Asn Met Asn Leu Asn Gly Glu Asn Leu Glu Asn Ser Gly Ser 
        195                 200                 205             


Thr Leu Ser Leu Asn Pro Leu Pro Ser His Ser Val Leu Asn Glu Ser 
    210                 215                 220                 


Lys Cys Phe Ile Lys Asp Asn Thr Leu Ala Leu Glu Ser Asn Tyr Pro 
225                 230                 235                 240 


Glu Asp Ser Leu Leu Ser Ser Ser Leu Asn Val Ala Ser Asp Ser Ile 
                245                 250                 255     


Ala Gly Cys Ser Ser Leu Asn Gln Lys Gln Lys Glu Leu Leu Glu Ser 
            260                 265                 270         


Glu Cys Val Glu Ala Gln Phe Ser Glu Ala Pro Val Asp Leu Asp Ala 
        275                 280                 285             


Ser Glu Pro Gln Ala Cys Leu Asn Leu Pro Gly Leu Asp Leu Pro Gly 
    290                 295                 300                 


Thr Gly Gly Asp Gln Lys Ser Thr Arg Val Ser Asp Val Phe Leu Pro 
305                 310                 315                 320 


Ser Glu Gly Phe Asn Phe Lys Pro His Lys His Pro Glu Leu Pro Thr 
                325                 330                 335     


Lys Gly Lys Asp Val Ser Tyr Cys Pro Val Leu Ala Pro Leu Pro Leu 
            340                 345                 350         


Leu Leu Pro Pro Pro Pro Pro Pro Pro Met Trp Asn Pro Met Ile Pro 
        355                 360                 365             


Ala Phe Asp Leu Phe Gln Gly Asn His Gly Phe Val Ala Pro Val Val 
    370                 375                 380                 


Thr Thr Ala Ala His Trp Arg Ser Val Asn Tyr Thr Phe Pro Pro Ser 
385                 390                 395                 400 


Val Ile Ser His Thr Ser Pro Thr Lys Val Trp Arg Asn Lys Asp Gly 
                405                 410                 415     


Thr Ser Ala Tyr Gln Val Gln Glu Thr Pro Val Ser Gln Val Val Arg 
            420                 425                 430         


Lys Lys Thr Ser Tyr Val Gly Leu Val Leu Val Leu Leu Arg Gly Leu 
        435                 440                 445             


Pro Gly Ser Gly Lys Ser Phe Leu Ala Arg Thr Leu Gln Glu Asp Asn 
    450                 455                 460                 


Pro Ser Gly Val Ile Leu Ser Thr Asp Asp Tyr Phe Tyr Ile Asn Gly 
465                 470                 475                 480 


Gln Tyr Gln Phe Asp Val Lys Tyr Leu Gly Glu Ala His Glu Trp Asn 
                485                 490                 495     


Gln Asn Arg Ala Lys Glu Ala Phe Glu Lys Lys Ile Ser Pro Ile Ile 
            500                 505                 510         


Ile Asp Asn Thr Asn Leu Gln Ala Trp Glu Met Lys Pro Tyr Val Ala 
        515                 520                 525             


Leu Ser Gln Lys His Lys Tyr Lys Val Leu Phe Arg Glu Pro Asp Thr 
    530                 535                 540                 


Trp Trp Lys Phe Lys Pro Lys Glu Leu Ala Arg Arg Asn Ile His Gly 
545                 550                 555                 560 


Val Ser Lys Glu Lys Ile Thr Arg Met Leu Glu His Tyr Gln Arg Phe 
                565                 570                 575     


Val Ser Val Pro Ile Ile Met Ser Ser Ser Val Pro Glu Lys Ile Glu 
            580                 585                 590         


Arg Ile Glu Leu Cys Ala Tyr Ser Cys Glu Asp Arg Ser Thr Ser Pro 
        595                 600                 605             


Arg Asp Asp Glu Asp Ile Ile Ser Glu Lys Glu Glu Asn Ile Leu Ser 
    610                 615                 620                 


Leu Ser Leu Lys His Leu Glu Phe Thr Glu Glu Lys Asn Leu Asp Val 
625                 630                 635                 640 


Thr Lys Glu Thr Met Leu Pro Glu Asn Val Ala Tyr Leu Ser Asn Ala 
                645                 650                 655     


Asp Leu Asn Lys Arg Arg Lys Glu Ile Ser Asp Met Asn Pro Ser Ile 
            660                 665                 670         


Gln Ser Ala Leu Ile Leu Glu Thr Pro His Met Tyr Phe Ser Asp Ser 
        675                 680                 685             


Glu Ser Lys Leu Gln Ala Thr Asp Lys Ser Glu Asn Glu Gln Ile Glu 
    690                 695                 700                 


Met Val Ala Val Lys Gly Tyr Ser Lys Thr Asp Thr Asp Ser Ser Met 
705                 710                 715                 720 


Glu Arg Val Ser Pro Ser Thr Cys Cys Ser Glu Asn Asn Gln Glu Asp 
                725                 730                 735     


Cys Asp Leu Ala Asn Ser Gly Pro Leu Gln Asn Glu Lys Ser Ser Pro 
            740                 745                 750         


Gly Glu Ile Val Glu Glu Arg Ala Thr Val Thr Lys Lys Ala Phe Gly 
        755                 760                 765             


Lys Gln Lys Ser Lys Ser Thr Leu Glu Lys Phe Pro Arg His Glu Leu 
    770                 775                 780                 


Ser Asn Phe Val Gly Asp Trp Pro Val Asp Lys Thr Ile Gly Gln Arg 
785                 790                 795                 800 


Thr Lys Arg Asn Arg Lys Thr Glu Lys Thr Ser Ser Val Gln Ser Asp 
                805                 810                 815     


Lys Lys Tyr Asn Tyr Pro Gln Ser His Lys Leu Val Asn Ser Val Ser 
            820                 825                 830         


Val Asn Thr Asp Cys Val Gln Gln Arg Gly Ser Pro His Glu Ser Val 
        835                 840                 845             


Glu Asp Gly Arg Lys Ser Gln Cys Asp Asp Ala Ser Glu Pro Leu Asn 
    850                 855                 860                 


Ser Tyr Lys Tyr Asp Ala Tyr Lys Asn Ile Asp Lys Asn Ser Phe Asn 
865                 870                 875                 880 


Ile Met Gly Asp Trp Pro Ser Ser Asp Ser Leu Ala Gln Arg Glu His 
                885                 890                 895     


Arg Ser Arg Met Pro Lys Thr Gly Leu Ser Glu Pro Asn Leu Glu Ile 
            900                 905                 910         


Gly Thr Asn Asp Lys Met Asn Glu Ile Ser Leu Ser Thr Ala His Glu 
        915                 920                 925             


Ala Cys Trp Gly Thr Ser Ser Gln Lys Leu Lys Thr Leu Gly Ser Ser 
    930                 935                 940                 


Asn Leu Gly Ser Ser Glu Met Leu Leu Ser Glu Met Thr Cys Glu Ser 
945                 950                 955                 960 


Gln Thr Cys Leu Ser Lys Lys Ser His Gly Gln His Thr Ser Leu Pro 
                965                 970                 975     


Leu Thr Phe Thr Asn Ser Ala Pro Thr Val Ser Gly Val Val Glu Pro 
            980                 985                 990         


Gln Thr Leu Ala Glu Cys Gln Glu  Gln Met Pro Lys Arg  Asp Pro Gly 
        995                 1000                 1005             


Lys Glu  Val Gly Met Cys Thr  Gln Thr Glu Pro Gln  Asp Phe Ala 
    1010                 1015                 1020             


Leu Leu  Trp Lys Ile Glu Lys  Asn Lys Ile Ser Ile  Ser Asp Ser 
    1025                 1030                 1035             


Ile Lys  Val Leu Thr Gly Arg  Leu Asp Gly Phe Lys  Pro Lys Val 
    1040                 1045                 1050             


Phe Asn  Ile Asn Thr Lys Ser  Asp Val Gln Glu Ala  Ile Pro Tyr 
    1055                 1060                 1065             


Arg Val  Met Tyr Asp Lys Ser  Thr Phe Val Glu Glu  Ser Glu Leu 
    1070                 1075                 1080             


Thr Ser  Ala Asp Glu Ser Glu  Asn Leu Asn Ile Leu  Cys Lys Leu 
    1085                 1090                 1095             


Phe Gly  Ser Phe Ser Leu Glu  Ala Leu Lys Asp Leu  Tyr Glu Arg 
    1100                 1105                 1110             


Cys Asn  Lys Asp Ile Ile Trp  Ala Thr Ser Leu Leu  Leu Asp Ser 
    1115                 1120                 1125             


Glu Thr  Lys Leu Cys Glu Asp  Thr Glu Phe Glu Asn  Phe Gln Lys 
    1130                 1135                 1140             


Ser Cys  Asp Gly Ser Gln Ile  Gly Pro Phe Ser Leu  Gly Leu Asn 
    1145                 1150                 1155             


Leu Lys  Glu Ile Ile Ser Gln  Arg Gly Thr Leu Glu  Asn Ser Asn 
    1160                 1165                 1170             


Ser Pro  Val Pro Glu Phe Ser  His Gly Ile Gly Ile  Ser Asn Ala 
    1175                 1180                 1185             


Asp Ser  Gln Ser Thr Cys Asp  Ala Glu Arg Gly Asn  Ser Glu Gln 
    1190                 1195                 1200             


Ala Glu  Met Arg Ala Val Thr  Pro Glu Asn His Glu  Ser Met Thr 
    1205                 1210                 1215             


Ser Ile  Phe Pro Ser Ala Ala  Val Gly Leu Lys Asn  Asn Asn Asp 
    1220                 1225                 1230             


Ile Leu  Pro Asn Ser Gln Glu  Glu Leu Leu Tyr Ser  Ser Lys Gln 
    1235                 1240                 1245             


Ser Phe  Pro Gly Ile Leu Lys  Ala Thr Thr Pro Lys  Asp Met Ser 
    1250                 1255                 1260             


Glu Thr  Glu Lys Asn Leu Val  Val Thr Glu Thr Gly  Asp Asn Ile 
    1265                 1270                 1275             


His Ser  Pro Ser His Phe Ser  Asp Ile Phe Asn Phe  Val Ser Ser 
    1280                 1285                 1290             


Thr Ser  Asn Leu Glu Leu Asn  Glu Glu Ile Tyr Phe  Thr Asp Ser 
    1295                 1300                 1305             


Leu Glu  Ile Lys Arg Asn Glu  Asn Phe Pro Lys Asp  Tyr Val Lys 
    1310                 1315                 1320             


Phe Ser  Asp Glu Glu Glu Phe  Met Asn Glu Asp Glu  Lys Glu Met 
    1325                 1330                 1335             


Lys Glu  Ile Leu Met Ala Gly  Ser Ser Leu Ser Ala  Gly Val Ser 
    1340                 1345                 1350             


Gly Glu  Asp Lys Thr Glu Ile  Leu Asn Pro Thr Pro  Ala Met Ala 
    1355                 1360                 1365             


Lys Ser  Leu Thr Ile Asp Cys  Leu Glu Leu Ala Leu  Pro Pro Glu 
    1370                 1375                 1380             


Leu Ala  Phe Gln Leu Asn Glu  Leu Phe Gly Pro Val  Gly Ile Asp 
    1385                 1390                 1395             


Ser Gly  Ser Leu Thr Val Glu  Asp Cys Val Val His  Ile Asp Leu 
    1400                 1405                 1410             


Asn Leu  Ala Lys Val Ile His  Glu Lys Trp Lys Glu  Ser Val Met 
    1415                 1420                 1425             


Glu Arg  Gln Arg Gln Glu Glu  Val Ser Cys Gly Lys  Phe Met Gln 
    1430                 1435                 1440             


Asp Pro  Ser Leu Val Gly His  Thr Gly Leu Asp Asn  Pro Glu Gln 
    1445                 1450                 1455             


Lys Ser  Ser Gln Arg Thr Gly  Lys Lys Leu Leu Lys  Thr Leu Thr 
    1460                 1465                 1470             


Ala Ser  Glu Met Leu Pro Leu  Leu Asp His Trp Asn  Thr Gln Thr 
    1475                 1480                 1485             


Lys Lys  Val Ser Leu Arg Glu  Ile Met Ser Glu Glu  Ile Ala Leu 
    1490                 1495                 1500             


Gln Glu  Lys His Asn Leu Lys  Arg Glu Thr Leu Met  Phe Glu Lys 
    1505                 1510                 1515             


Asp Cys  Ala Thr Lys Leu Lys  Glu Lys Gln Leu Phe  Lys Ile Phe 
    1520                 1525                 1530             


Pro Ala  Ile Asn Gln Asn Phe  Leu Val Asp Ile Phe  Lys Asp His 
    1535                 1540                 1545             


Asn Tyr  Ser Leu Glu His Thr  Val Gln Phe Leu Asn  Cys Val Leu 
    1550                 1555                 1560             


Glu Gly  Asp Pro Val Lys Thr  Val Val Ala Gln Glu  Phe Val His 
    1565                 1570                 1575             


Gln Asn  Glu Asn Val Thr Ser  His Thr Gly Gln Lys  Ser Lys Glu 
    1580                 1585                 1590             


Lys Lys  Pro Lys Lys Leu Lys  Glu Thr Glu Glu Thr  Pro Ser Glu 
    1595                 1600                 1605             


Leu Ser  Phe Gln Asp Phe Glu  Tyr Pro Asp Tyr Asp  Asp Tyr Arg 
    1610                 1615                 1620             


Ala Glu  Ala Phe Leu His Gln  Gln Lys Arg Met Glu  Cys Tyr Ser 
    1625                 1630                 1635             


Lys Ala  Lys Glu Ala Tyr Arg  Ile Gly Lys Lys Asn  Val Ala Thr 
    1640                 1645                 1650             


Phe Tyr  Ala Gln Gln Gly Thr  Leu His Glu Gln Lys  Met Lys Glu 
    1655                 1660                 1665             


Ala Asn  His Leu Ala Ala Ile  Glu Ile Phe Glu Lys  Val Asn Ala 
    1670                 1675                 1680             


Ser Leu  Leu Pro Gln Asn Val  Leu Asp Leu His Gly  Leu His Val 
    1685                 1690                 1695             


Asp Glu  Ala Leu Glu His Leu  Met Arg Val Leu Glu  Lys Lys Thr 
    1700                 1705                 1710             


Glu Glu  Phe Lys Gln Asn Gly  Gly Lys Pro Tyr Leu  Ser Val Ile 
    1715                 1720                 1725             


Thr Gly  Arg Gly Asn His Ser  Gln Gly Gly Val Ala  Arg Ile Lys 
    1730                 1735                 1740             


Pro Ala  Val Ile Lys Tyr Leu  Ile Ser His Ser Phe  Arg Phe Ser 
    1745                 1750                 1755             


Glu Ile  Lys Pro Gly Cys Leu  Lys Val Met Leu Lys  
    1760                 1765                 1770 


<210> 4897
<211> 453
<212> PRT
<213> Homo sapiens

<400> 4897
Met Asp Trp Lys Glu Val Leu Arg Arg Arg Leu Ala Thr Pro Asn Thr 
1               5                   10                  15      


Cys Pro Asn Lys Lys Lys Ser Glu Gln Glu Leu Lys Asp Glu Glu Met 
            20                  25                  30          


Asp Leu Phe Thr Lys Tyr Tyr Ser Glu Trp Lys Gly Gly Arg Lys Asn 
        35                  40                  45              


Thr Asn Glu Phe Tyr Lys Thr Ile Pro Arg Phe Tyr Tyr Arg Leu Pro 
    50                  55                  60                  


Ala Glu Asp Glu Val Leu Leu Gln Lys Leu Arg Glu Glu Ser Arg Ala 
65                  70                  75                  80  


Val Phe Leu Gln Arg Lys Ser Arg Glu Leu Leu Asp Asn Glu Glu Leu 
                85                  90                  95      


Gln Asn Leu Trp Phe Leu Leu Asp Lys His Gln Thr Pro Pro Met Ile 
            100                 105                 110         


Gly Glu Glu Ala Met Ile Asn Tyr Glu Asn Phe Leu Lys Val Gly Glu 
        115                 120                 125             


Lys Ala Gly Ala Lys Cys Lys Gln Phe Phe Thr Ala Lys Val Phe Ala 
    130                 135                 140                 


Lys Leu Leu His Thr Asp Ser Tyr Gly Arg Ile Ser Ile Met Gln Phe 
145                 150                 155                 160 


Phe Asn Tyr Val Met Arg Lys Val Trp Leu His Gln Thr Arg Ile Gly 
                165                 170                 175     


Leu Ser Leu Tyr Asp Val Ala Gly Gln Gly Tyr Leu Arg Glu Ser Asp 
            180                 185                 190         


Leu Glu Asn Tyr Ile Leu Glu Leu Ile Pro Thr Leu Pro Gln Leu Asp 
        195                 200                 205             


Gly Leu Glu Lys Ser Phe Tyr Ser Phe Tyr Val Cys Thr Ala Val Arg 
    210                 215                 220                 


Lys Phe Phe Phe Phe Leu Asp Pro Leu Arg Thr Gly Lys Ile Lys Ile 
225                 230                 235                 240 


Gln Asp Ile Leu Ala Cys Ser Phe Leu Asp Asp Leu Leu Glu Leu Arg 
                245                 250                 255     


Asp Glu Glu Leu Ser Lys Glu Ser Gln Glu Thr Asn Trp Phe Ser Ala 
            260                 265                 270         


Pro Ser Ala Leu Arg Val Tyr Gly Gln Tyr Leu Asn Leu Asp Lys Asp 
        275                 280                 285             


His Asn Gly Met Leu Ser Lys Glu Glu Leu Ser Arg Tyr Gly Thr Ala 
    290                 295                 300                 


Thr Met Thr Asn Val Phe Leu Asp Arg Val Phe Gln Glu Cys Leu Thr 
305                 310                 315                 320 


Tyr Asp Gly Glu Met Asp Tyr Lys Thr Tyr Leu Asp Phe Val Leu Ala 
                325                 330                 335     


Leu Glu Asn Arg Lys Glu Pro Ala Ala Leu Gln Tyr Ile Phe Lys Leu 
            340                 345                 350         


Leu Asp Ile Glu Asn Lys Gly Tyr Leu Asn Val Phe Ser Leu Asn Tyr 
        355                 360                 365             


Phe Phe Arg Ala Ile Gln Glu Leu Met Lys Ile His Gly Gln Asp Pro 
    370                 375                 380                 


Val Ser Phe Gln Asp Val Lys Asp Glu Ile Phe Asp Met Val Lys Pro 
385                 390                 395                 400 


Lys Asp Pro Leu Lys Ile Ser Leu Gln Asp Leu Ile Asn Ser Asn Gln 
                405                 410                 415     


Gly Asp Thr Val Thr Thr Ile Leu Ile Asp Leu Asn Gly Phe Trp Thr 
            420                 425                 430         


Tyr Glu Asn Arg Glu Ala Leu Val Ala Asn Asp Ser Glu Asn Ser Ala 
        435                 440                 445             


Asp Leu Asp Asp Thr 
    450             


<210> 4898
<211> 1115
<212> PRT
<213> Homo sapiens

<400> 4898
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser Glu Leu Leu 
            100                 105                 110         


Met Ile Ile Gln Met Glu Thr Gln Ser Ser Met Arg Lys Lys Val Cys 
        115                 120                 125             


Asp Ile Ala Ala Glu Leu Ala Arg Asn Leu Ile Asp Glu Asp Gly Asn 
    130                 135                 140                 


Asn Gln Trp Pro Glu Gly Leu Lys Phe Leu Phe Asp Ser Val Ser Ser 
145                 150                 155                 160 


Gln Asn Val Gly Leu Arg Glu Ala Ala Leu His Ile Phe Trp Asn Phe 
                165                 170                 175     


Pro Gly Ile Phe Gly Asn Gln Gln Gln His Tyr Leu Asp Val Ile Lys 
            180                 185                 190         


Arg Met Leu Val Gln Cys Met Gln Asp Gln Glu His Pro Ser Ile Arg 
        195                 200                 205             


Thr Leu Ser Ala Arg Ala Thr Ala Ala Phe Ile Leu Ala Asn Glu His 
    210                 215                 220                 


Asn Val Ala Leu Phe Lys His Phe Ala Asp Leu Leu Pro Gly Phe Leu 
225                 230                 235                 240 


Gln Ala Val Asn Asp Ser Cys Tyr Gln Asn Asp Asp Ser Val Leu Lys 
                245                 250                 255     


Ser Leu Val Glu Ile Ala Asp Thr Val Pro Lys Tyr Leu Arg Pro His 
            260                 265                 270         


Leu Glu Ala Thr Leu Gln Leu Ser Leu Lys Leu Cys Gly Asp Thr Ser 
        275                 280                 285             


Leu Asn Asn Met Gln Arg Gln Leu Ala Leu Glu Val Ile Val Thr Leu 
    290                 295                 300                 


Ser Glu Thr Ala Ala Ala Met Leu Arg Lys His Thr Asn Ile Val Ala 
305                 310                 315                 320 


Gln Thr Ile Pro Gln Met Leu Ala Met Met Val Asp Leu Glu Glu Asp 
                325                 330                 335     


Glu Asp Trp Ala Asn Ala Asp Glu Leu Glu Asp Asp Asp Phe Asp Ser 
            340                 345                 350         


Asn Ala Val Ala Gly Glu Ser Ala Leu Asp Arg Met Ala Cys Gly Leu 
        355                 360                 365             


Gly Gly Lys Leu Val Leu Pro Met Ile Lys Glu His Ile Met Gln Met 
    370                 375                 380                 


Leu Gln Asn Pro Asp Trp Lys Tyr Arg His Ala Gly Leu Met Ala Leu 
385                 390                 395                 400 


Ser Ala Ile Gly Glu Gly Cys His Gln Gln Met Glu Gly Ile Leu Asn 
                405                 410                 415     


Glu Ile Val Asn Phe Val Leu Leu Phe Leu Gln Asp Pro His Pro Arg 
            420                 425                 430         


Val Arg Tyr Ala Ala Cys Asn Ala Val Gly Gln Met Ala Thr Asp Phe 
        435                 440                 445             


Ala Pro Gly Phe Gln Lys Lys Phe His Glu Lys Val Ile Ala Ala Leu 
    450                 455                 460                 


Leu Gln Thr Met Glu Asp Gln Gly Asn Gln Arg Val Gln Ala His Ala 
465                 470                 475                 480 


Ala Ala Ala Leu Ile Asn Phe Thr Glu Asp Cys Pro Lys Ser Leu Leu 
                485                 490                 495     


Ile Pro Tyr Leu Asp Asn Leu Val Lys His Leu His Ser Ile Met Val 
            500                 505                 510         


Leu Lys Leu Gln Glu Leu Ile Gln Lys Gly Thr Lys Leu Val Leu Glu 
        515                 520                 525             


Gln Val Val Thr Ser Ile Ala Ser Val Ala Asp Thr Ala Glu Glu Lys 
    530                 535                 540                 


Phe Val Pro Tyr Tyr Asp Leu Phe Met Pro Ser Leu Lys His Ile Val 
545                 550                 555                 560 


Glu Asn Ala Val Gln Lys Glu Leu Arg Leu Leu Arg Gly Lys Thr Ile 
                565                 570                 575     


Glu Cys Ile Ser Leu Ile Gly Leu Ala Val Gly Lys Glu Lys Phe Met 
            580                 585                 590         


Gln Asp Ala Ser Asp Val Met Gln Leu Leu Leu Lys Thr Gln Thr Asp 
        595                 600                 605             


Phe Asn Asp Met Glu Asp Asp Asp Pro Gln Ile Ser Tyr Met Ile Ser 
    610                 615                 620                 


Ala Trp Ala Arg Met Cys Lys Ile Leu Gly Lys Glu Phe Gln Gln Tyr 
625                 630                 635                 640 


Leu Pro Val Val Met Gly Pro Leu Met Lys Thr Ala Ser Ile Lys Pro 
                645                 650                 655     


Glu Val Ala Leu Leu Asp Thr Gln Asp Met Glu Asn Met Ser Asp Asp 
            660                 665                 670         


Asp Gly Trp Glu Phe Val Asn Leu Gly Asp Gln Gln Ser Phe Gly Ile 
        675                 680                 685             


Lys Thr Ala Gly Leu Glu Glu Lys Ser Thr Ala Cys Gln Met Leu Val 
    690                 695                 700                 


Cys Tyr Ala Lys Glu Leu Lys Glu Gly Phe Val Glu Tyr Thr Glu Gln 
705                 710                 715                 720 


Val Val Lys Leu Met Val Pro Leu Leu Lys Phe Tyr Phe His Asp Gly 
                725                 730                 735     


Val Arg Val Ala Ala Ala Glu Ser Met Pro Leu Leu Leu Glu Cys Ala 
            740                 745                 750         


Arg Val Arg Gly Pro Glu Tyr Leu Thr Gln Met Trp His Phe Met Cys 
        755                 760                 765             


Asp Ala Leu Ile Lys Ala Ile Gly Thr Glu Pro Asp Ser Asp Val Leu 
    770                 775                 780                 


Ser Glu Ile Met His Ser Phe Ala Lys Cys Ile Glu Val Met Gly Asp 
785                 790                 795                 800 


Gly Cys Leu Asn Asn Glu His Phe Glu Glu Leu Gly Gly Ile Leu Lys 
                805                 810                 815     


Ala Lys Leu Glu Glu His Phe Lys Asn Gln Glu Leu Arg Gln Val Lys 
            820                 825                 830         


Arg Gln Asp Glu Asp Tyr Asp Glu Gln Val Glu Glu Ser Leu Gln Asp 
        835                 840                 845             


Glu Asp Asp Asn Asp Val Tyr Ile Leu Thr Lys Val Ser Asp Ile Leu 
    850                 855                 860                 


His Ser Ile Phe Ser Ser Tyr Lys Glu Lys Val Leu Pro Trp Phe Glu 
865                 870                 875                 880 


Gln Leu Leu Pro Leu Ile Val Asn Leu Ile Cys Pro His Arg Pro Trp 
                885                 890                 895     


Pro Asp Arg Gln Trp Gly Leu Cys Ile Phe Asp Asp Val Ile Glu His 
            900                 905                 910         


Cys Ser Pro Ala Ser Phe Lys Tyr Ala Glu Tyr Phe Leu Arg Pro Met 
        915                 920                 925             


Leu Gln Tyr Val Cys Asp Asn Ser Pro Glu Val Arg Gln Ala Ala Ala 
    930                 935                 940                 


Tyr Gly Leu Gly Val Met Ala Gln Tyr Gly Gly Asp Asn Tyr Arg Pro 
945                 950                 955                 960 


Phe Cys Thr Glu Ala Leu Pro Leu Leu Val Arg Val Ile Gln Ser Ala 
                965                 970                 975     


Asp Ser Lys Thr Lys Glu Asn Val Asn Ala Thr Glu Asn Cys Ile Ser 
            980                 985                 990         


Ala Val Gly Lys Ile Met Lys Phe  Lys Pro Asp Cys Val  Asn Val Glu 
        995                 1000                 1005             


Glu Val  Leu Pro His Trp Leu  Ser Trp Leu Pro Leu  His Glu Asp 
    1010                 1015                 1020             


Lys Glu  Glu Ala Val Gln Thr  Phe Asn Tyr Leu Cys  Asp Leu Ile 
    1025                 1030                 1035             


Glu Ser  Asn His Pro Ile Val  Leu Gly Pro Asn Asn  Thr Asn Leu 
    1040                 1045                 1050             


Pro Lys  Ile Phe Ser Ile Ile  Ala Glu Gly Glu Met  His Glu Ala 
    1055                 1060                 1065             


Ile Lys  His Glu Asp Pro Cys  Ala Lys Arg Leu Ala  Asn Val Val 
    1070                 1075                 1080             


Arg Gln  Val Gln Thr Ser Gly  Gly Leu Trp Thr Glu  Cys Ile Ala 
    1085                 1090                 1095             


Gln Leu  Ser Pro Glu Gln Gln  Ala Ala Ile Gln Glu  Leu Leu Asn 
    1100                 1105                 1110             


Ser Ala  
    1115 


<210> 4899
<211> 642
<212> PRT
<213> Homo sapiens

<400> 4899
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met 
1               5                   10                  15      


Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro 
            20                  25                  30          


Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro 
        35                  40                  45              


Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His 
    50                  55                  60                  


Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile 
65                  70                  75                  80  


Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile 
                85                  90                  95      


Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val 
            100                 105                 110         


Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile 
        115                 120                 125             


Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp 
    130                 135                 140                 


Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr 
145                 150                 155                 160 


Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His 
                165                 170                 175     


Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile 
            180                 185                 190         


Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly 
        195                 200                 205             


Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu 
    210                 215                 220                 


Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala 
225                 230                 235                 240 


Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp 
                245                 250                 255     


Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn 
            260                 265                 270         


Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys 
        275                 280                 285             


Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln 
    290                 295                 300                 


Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His 
305                 310                 315                 320 


Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala 
                325                 330                 335     


Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu 
            340                 345                 350         


Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg 
        355                 360                 365             


Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr 
    370                 375                 380                 


Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys 
385                 390                 395                 400 


Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His 
                405                 410                 415     


Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser 
            420                 425                 430         


Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn 
        435                 440                 445             


Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu 
    450                 455                 460                 


Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met 
465                 470                 475                 480 


Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser 
                485                 490                 495     


Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp 
            500                 505                 510         


Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys 
        515                 520                 525             


Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser 
    530                 535                 540                 


Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val 
545                 550                 555                 560 


Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg 
                565                 570                 575     


Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His 
            580                 585                 590         


Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp 
        595                 600                 605             


Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys 
    610                 615                 620                 


Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser 
625                 630                 635                 640 


Glu Glu 
        


<210> 4900
<211> 1589
<212> PRT
<213> Homo sapiens

<400> 4900
Met Ser Leu Pro Phe Tyr Gln Arg Cys His Gln His Tyr Asp Leu Ser 
1               5                   10                  15      


Tyr Arg Asn Lys Asp Val Arg Ser Thr Val Ser His Tyr Gln Arg Glu 
            20                  25                  30          


Lys Lys Arg Ser Ala Val Tyr Thr Gln Gly Ser Thr Ala Tyr Ser Ser 
        35                  40                  45              


Arg Ser Ser Ala Ala His Arg Arg Glu Ser Glu Ala Phe Arg Arg Ala 
    50                  55                  60                  


Ser Ala Ser Ser Ser Gln Gln Gln Ala Ser Gln His Ala Leu Ser Ser 
65                  70                  75                  80  


Glu Val Ser Arg Lys Ala Ala Ser Ala Tyr Asp Tyr Gly Ser Ser His 
                85                  90                  95      


Gly Leu Thr Asp Ser Ser Leu Leu Leu Asp Asp Tyr Ser Ser Lys Leu 
            100                 105                 110         


Ser Pro Lys Pro Lys Arg Ala Lys His Ser Leu Leu Ser Gly Glu Glu 
        115                 120                 125             


Lys Glu Asn Leu Pro Ser Asp Tyr Met Val Pro Ile Phe Ser Gly Arg 
    130                 135                 140                 


Gln Lys His Val Ser Gly Ile Thr Asp Thr Glu Glu Glu Arg Ile Lys 
145                 150                 155                 160 


Glu Ala Ala Ala Tyr Ile Ala Gln Arg Asn Leu Leu Ala Ser Glu Glu 
                165                 170                 175     


Gly Ile Thr Thr Ser Lys Gln Ser Thr Ala Ser Lys Gln Thr Thr Ala 
            180                 185                 190         


Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser 
        195                 200                 205             


Thr Ala Ser Arg Gln Ser Thr Ala Ser Arg Gln Ser Val Val Ser Lys 
    210                 215                 220                 


Gln Ala Thr Ser Ala Leu Gln Gln Glu Glu Thr Ser Glu Lys Lys Ser 
225                 230                 235                 240 


Arg Lys Val Val Ile Arg Glu Lys Ala Glu Arg Leu Ser Leu Arg Lys 
                245                 250                 255     


Thr Leu Glu Glu Thr Glu Thr Tyr His Ala Lys Leu Asn Glu Asp His 
            260                 265                 270         


Leu Leu His Ala Pro Glu Phe Ile Ile Lys Pro Arg Ser His Thr Val 
        275                 280                 285             


Trp Glu Lys Glu Asn Val Lys Leu His Cys Ser Ile Ala Gly Trp Pro 
    290                 295                 300                 


Glu Pro Arg Val Thr Trp Tyr Lys Asn Gln Val Pro Ile Asn Val His 
305                 310                 315                 320 


Ala Asn Pro Gly Lys Tyr Ile Ile Glu Ser Arg Tyr Gly Met His Thr 
                325                 330                 335     


Leu Glu Ile Asn Gly Cys Asp Phe Glu Asp Thr Ala Gln Tyr Arg Ala 
            340                 345                 350         


Ser Ala Met Asn Val Lys Gly Glu Leu Ser Ala Tyr Ala Ser Val Val 
        355                 360                 365             


Val Lys Arg Tyr Lys Gly Glu Phe Asp Glu Thr Arg Phe His Ala Gly 
    370                 375                 380                 


Ala Ser Thr Met Pro Leu Ser Phe Gly Val Thr Pro Tyr Gly Tyr Ala 
385                 390                 395                 400 


Ser Arg Phe Glu Ile His Phe Asp Asp Lys Phe Asp Val Ser Phe Gly 
                405                 410                 415     


Arg Glu Gly Glu Thr Met Ser Leu Gly Cys Arg Val Val Ile Thr Pro 
            420                 425                 430         


Glu Ile Lys His Phe Gln Pro Glu Ile Gln Trp Tyr Arg Asn Gly Val 
        435                 440                 445             


Pro Leu Ser Pro Ser Lys Trp Val Gln Thr Leu Trp Ser Gly Glu Arg 
    450                 455                 460                 


Ala Thr Leu Thr Phe Ser His Leu Asn Lys Glu Asp Glu Gly Leu Tyr 
465                 470                 475                 480 


Thr Ile Arg Val Arg Met Gly Glu Tyr Tyr Glu Gln Tyr Ser Ala Tyr 
                485                 490                 495     


Val Phe Val Arg Asp Ala Asp Ala Glu Ile Glu Gly Ala Pro Ala Ala 
            500                 505                 510         


Pro Leu Asp Val Lys Cys Leu Glu Ala Asn Lys Asp Tyr Ile Ile Ile 
        515                 520                 525             


Ser Trp Lys Gln Pro Ala Val Asp Gly Gly Ser Pro Ile Leu Gly Tyr 
    530                 535                 540                 


Phe Ile Asp Lys Cys Glu Val Gly Thr Asp Ser Trp Ser Gln Cys Asn 
545                 550                 555                 560 


Asp Thr Pro Val Lys Phe Ala Arg Phe Pro Val Thr Gly Leu Ile Glu 
                565                 570                 575     


Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Lys Met Gly Ile 
            580                 585                 590         


Gly Phe Pro Ser Arg Val Ser Glu Pro Val Ala Ala Leu Asp Pro Ala 
        595                 600                 605             


Glu Lys Ala Arg Leu Lys Ser Arg Pro Ser Ala Pro Trp Thr Gly Gln 
    610                 615                 620                 


Ile Ile Val Thr Glu Glu Glu Pro Ser Glu Gly Ile Val Pro Gly Pro 
625                 630                 635                 640 


Pro Thr Asp Leu Ser Val Thr Glu Ala Thr Arg Ser Tyr Val Val Leu 
                645                 650                 655     


Ser Trp Lys Pro Pro Gly Gln Arg Gly His Glu Gly Ile Met Tyr Phe 
            660                 665                 670         


Val Glu Lys Cys Glu Ala Gly Thr Glu Asn Trp Gln Arg Val Asn Thr 
        675                 680                 685             


Glu Leu Pro Val Lys Ser Pro Arg Phe Ala Leu Phe Asp Leu Ala Glu 
    690                 695                 700                 


Gly Lys Ser Tyr Cys Phe Arg Val Arg Cys Ser Asn Ser Ala Gly Val 
705                 710                 715                 720 


Gly Glu Pro Ser Glu Ala Thr Glu Val Thr Val Val Gly Asp Lys Leu 
                725                 730                 735     


Asp Ile Pro Lys Ala Pro Gly Lys Ile Ile Pro Ser Arg Asn Thr Asp 
            740                 745                 750         


Thr Ser Val Val Val Ser Trp Glu Glu Ser Lys Asp Ala Lys Glu Leu 
        755                 760                 765             


Val Gly Tyr Tyr Ile Glu Ala Ser Val Ala Gly Ser Gly Lys Trp Glu 
    770                 775                 780                 


Pro Cys Asn Asn Asn Pro Val Lys Gly Ser Arg Phe Thr Cys His Gly 
785                 790                 795                 800 


Leu Val Thr Gly Gln Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ala 
                805                 810                 815     


Ala Gly Leu Ser Glu Tyr Ser Gln Asp Ser Glu Ala Ile Glu Val Lys 
            820                 825                 830         


Ala Ala Ile Ala Pro Pro Ser Pro Pro Cys Asp Ile Thr Cys Leu Glu 
        835                 840                 845             


Ser Phe Arg Asp Ser Met Val Leu Gly Trp Lys Gln Pro Asp Lys Ile 
    850                 855                 860                 


Gly Gly Ala Glu Ile Thr Gly Tyr Tyr Val Asn Tyr Arg Glu Val Ile 
865                 870                 875                 880 


Asp Gly Val Pro Gly Lys Trp Arg Glu Ala Asn Val Lys Ala Val Ser 
                885                 890                 895     


Glu Glu Ala Tyr Lys Ile Ser Asn Leu Lys Glu Asn Met Val Tyr Gln 
            900                 905                 910         


Phe Gln Val Ala Ala Met Asn Met Ala Gly Leu Gly Ala Pro Ser Ala 
        915                 920                 925             


Val Ser Glu Cys Phe Lys Cys Glu Glu Trp Thr Ile Ala Val Pro Gly 
    930                 935                 940                 


Pro Pro His Ser Leu Lys Cys Ser Glu Val Arg Lys Asp Ser Leu Val 
945                 950                 955                 960 


Leu Gln Trp Lys Pro Pro Val His Ser Gly Arg Thr Pro Val Thr Gly 
                965                 970                 975     


Tyr Phe Val Asp Leu Lys Glu Ala Lys Ala Lys Glu Asp Gln Trp Arg 
            980                 985                 990         


Gly Leu Asn Glu Ala Ala Ile Lys  Asn Val Tyr Leu Lys  Val Arg Gly 
        995                 1000                 1005             


Leu Lys  Glu Gly Val Ser Tyr  Val Phe Arg Val Arg  Ala Ile Asn 
    1010                 1015                 1020             


Gln Ala  Gly Val Gly Lys Pro  Ser Asp Leu Ala Gly  Pro Val Val 
    1025                 1030                 1035             


Ala Glu  Thr Arg Pro Gly Thr  Lys Glu Val Val Val  Asn Val Asp 
    1040                 1045                 1050             


Asp Asp  Gly Val Ile Ser Leu  Asn Phe Glu Cys Asp  Lys Met Thr 
    1055                 1060                 1065             


Pro Lys  Ser Glu Phe Ser Trp  Ser Lys Asp Tyr Val  Ser Thr Glu 
    1070                 1075                 1080             


Asp Ser  Pro Arg Leu Glu Val  Glu Ser Lys Gly Asn  Lys Thr Lys 
    1085                 1090                 1095             


Met Thr  Phe Lys Asp Leu Gly  Met Asp Asp Leu Gly  Ile Tyr Ser 
    1100                 1105                 1110             


Cys Asp  Val Thr Asp Thr Asp  Gly Ile Ala Ser Ser  Tyr Leu Ile 
    1115                 1120                 1125             


Asp Glu  Glu Glu Leu Lys Arg  Leu Leu Ala Leu Ser  His Glu His 
    1130                 1135                 1140             


Lys Phe  Pro Thr Val Pro Val  Lys Ser Glu Leu Ala  Val Glu Ile 
    1145                 1150                 1155             


Leu Glu  Lys Gly Gln Val Arg  Phe Trp Met Gln Ala  Glu Lys Leu 
    1160                 1165                 1170             


Ser Gly  Asn Ala Lys Val Asn  Tyr Ile Phe Asn Glu  Lys Glu Ile 
    1175                 1180                 1185             


Phe Glu  Gly Pro Lys Tyr Lys  Met His Ile Asp Arg  Asn Thr Gly 
    1190                 1195                 1200             


Ile Ile  Glu Met Phe Met Glu  Lys Leu Gln Asp Glu  Asp Glu Gly 
    1205                 1210                 1215             


Thr Tyr  Thr Phe Gln Leu Gln  Asp Gly Lys Ala Thr  Asn His Ser 
    1220                 1225                 1230             


Thr Val  Val Leu Val Gly Asp  Val Phe Lys Lys Leu  Gln Lys Glu 
    1235                 1240                 1245             


Ala Glu  Phe Gln Arg Gln Glu  Trp Ile Arg Lys Gln  Gly Pro His 
    1250                 1255                 1260             


Phe Val  Glu Tyr Leu Ser Trp  Glu Val Thr Gly Glu  Cys Asn Val 
    1265                 1270                 1275             


Leu Leu  Lys Cys Lys Val Ala  Asn Ile Lys Lys Glu  Thr His Ile 
    1280                 1285                 1290             


Val Trp  Tyr Lys Asp Glu Arg  Glu Ile Ser Val Asp  Glu Lys His 
    1295                 1300                 1305             


Asp Phe  Lys Asp Gly Ile Cys  Thr Leu Leu Ile Thr  Glu Phe Ser 
    1310                 1315                 1320             


Lys Lys  Asp Ala Gly Ile Tyr  Glu Val Ile Leu Lys  Asp Asp Arg 
    1325                 1330                 1335             


Gly Lys  Asp Lys Ser Arg Leu  Lys Leu Val Asp Glu  Ala Phe Lys 
    1340                 1345                 1350             


Glu Leu  Met Met Glu Val Cys  Lys Lys Ile Ala Leu  Ser Ala Thr 
    1355                 1360                 1365             


Asp Leu  Lys Ile Gln Ser Thr  Ala Glu Gly Ile Gln  Leu Tyr Ser 
    1370                 1375                 1380             


Phe Val  Thr Tyr Tyr Val Glu  Asp Leu Lys Val Asn  Trp Ser His 
    1385                 1390                 1395             


Asn Gly  Ser Ala Ile Arg Tyr  Ser Asp Arg Val Lys  Thr Gly Val 
    1400                 1405                 1410             


Thr Gly  Glu Gln Ile Trp Leu  Gln Ile Asn Glu Pro  Thr Pro Asn 
    1415                 1420                 1425             


Asp Lys  Gly Lys Tyr Val Met  Glu Leu Phe Asp Gly  Lys Thr Gly 
    1430                 1435                 1440             


His Gln  Lys Thr Val Asp Leu  Ser Gly Gln Ala Tyr  Asp Glu Ala 
    1445                 1450                 1455             


Tyr Ala  Glu Phe Gln Arg Leu  Lys Gln Ala Ala Ile  Ala Glu Lys 
    1460                 1465                 1470             


Asn Arg  Ala Arg Val Leu Gly  Gly Leu Pro Asp Val  Val Thr Ile 
    1475                 1480                 1485             


Gln Glu  Gly Lys Ala Leu Asn  Leu Thr Cys Asn Val  Trp Gly Asp 
    1490                 1495                 1500             


Pro Pro  Pro Glu Val Ser Trp  Leu Lys Asn Glu Lys  Ala Leu Ala 
    1505                 1510                 1515             


Ser Asp  Asp His Cys Asn Leu  Lys Phe Glu Ala Gly  Arg Thr Ala 
    1520                 1525                 1530             


Tyr Phe  Thr Ile Asn Gly Val  Ser Thr Ala Asp Ser  Gly Lys Tyr 
    1535                 1540                 1545             


Gly Leu  Val Val Lys Asn Lys  Tyr Gly Ser Glu Thr  Ser Asp Phe 
    1550                 1555                 1560             


Thr Val  Ser Val Phe Ile Pro  Glu Glu Glu Ala Arg  Met Ala Ala 
    1565                 1570                 1575             


Leu Glu  Ser Leu Lys Gly Gly  Lys Lys Ala Lys 
    1580                 1585                 


<210> 4901
<211> 181
<212> PRT
<213> Homo sapiens

<400> 4901
Met Gly Gly Phe Phe Ser Ser Ile Phe Ser Ser Leu Phe Gly Thr Arg 
1               5                   10                  15      


Glu Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Arg Leu Gln Val Gly Glu Val Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Thr Tyr Lys Asn Leu Lys Phe Gln 
    50                  55                  60                  


Val Trp Asp Leu Gly Gly Gln Thr Ser Ile Arg Pro Tyr Trp Arg Cys 
65                  70                  75                  80  


Tyr Tyr Ser Asn Thr Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp 
                85                  90                  95      


Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu 
            100                 105                 110         


Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Met Glu Gln Ala Met Thr Ser Ser Glu Met Ala Asn Ser Leu Gly 
    130                 135                 140                 


Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Thr Ser Ala 
145                 150                 155                 160 


Thr Lys Gly Thr Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Thr 
                165                 170                 175     


Leu Lys Ser Arg Gln 
            180     


<210> 4902
<211> 422
<212> PRT
<213> Homo sapiens

<400> 4902
Met Ala Ala Ala Ala Val Val Glu Phe Gln Arg Ala Gln Ser Leu Leu 
1               5                   10                  15      


Ser Thr Asp Arg Glu Ala Ser Ile Asp Ile Leu His Ser Ile Val Lys 
            20                  25                  30          


Arg Asp Ile Gln Glu Asn Asp Glu Glu Ala Val Gln Val Lys Glu Gln 
        35                  40                  45              


Ser Ile Leu Glu Leu Gly Ser Leu Leu Ala Lys Thr Gly Gln Ala Ala 
    50                  55                  60                  


Glu Leu Gly Gly Leu Leu Lys Tyr Val Arg Pro Phe Leu Asn Ser Ile 
65                  70                  75                  80  


Ser Lys Ala Lys Ala Ala Arg Leu Val Arg Ser Leu Leu Asp Leu Phe 
                85                  90                  95      


Leu Asp Met Glu Ala Ala Thr Gly Gln Glu Val Glu Leu Cys Leu Glu 
            100                 105                 110         


Cys Ile Glu Trp Ala Lys Ser Glu Lys Arg Thr Phe Leu Arg Gln Ala 
        115                 120                 125             


Leu Glu Ala Arg Leu Val Ser Leu Tyr Phe Asp Thr Lys Arg Tyr Gln 
    130                 135                 140                 


Glu Ala Leu His Leu Gly Ser Gln Leu Leu Arg Glu Leu Lys Lys Met 
145                 150                 155                 160 


Asp Asp Lys Ala Leu Leu Val Glu Val Gln Leu Leu Glu Ser Lys Thr 
                165                 170                 175     


Tyr His Ala Leu Ser Asn Leu Pro Lys Ala Arg Ala Ala Leu Thr Ser 
            180                 185                 190         


Ala Arg Thr Thr Ala Asn Ala Ile Tyr Cys Pro Pro Lys Leu Gln Ala 
        195                 200                 205             


Thr Leu Asp Met Gln Ser Gly Ile Ile His Ala Ala Glu Glu Lys Asp 
    210                 215                 220                 


Trp Lys Thr Ala Tyr Ser Tyr Phe Tyr Glu Ala Phe Glu Gly Tyr Asp 
225                 230                 235                 240 


Ser Ile Asp Ser Pro Lys Ala Ile Thr Ser Leu Lys Tyr Met Leu Leu 
                245                 250                 255     


Cys Lys Ile Met Leu Asn Thr Pro Glu Asp Val Gln Ala Leu Val Ser 
            260                 265                 270         


Gly Lys Leu Ala Leu Arg Tyr Ala Gly Arg Gln Thr Glu Ala Leu Lys 
        275                 280                 285             


Cys Val Ala Gln Ala Ser Lys Asn Arg Ser Leu Ala Asp Phe Glu Lys 
    290                 295                 300                 


Ala Leu Thr Asp Tyr Arg Ala Glu Leu Arg Asp Asp Pro Ile Ile Ser 
305                 310                 315                 320 


Thr His Leu Ala Lys Leu Tyr Asp Asn Leu Leu Glu Gln Asn Leu Ile 
                325                 330                 335     


Arg Val Ile Glu Pro Phe Ser Arg Val Gln Ile Glu His Ile Ser Ser 
            340                 345                 350         


Leu Ile Lys Leu Ser Lys Ala Asp Val Glu Arg Lys Leu Ser Gln Met 
        355                 360                 365             


Ile Leu Asp Lys Lys Phe His Gly Ile Leu Asp Gln Gly Glu Gly Val 
    370                 375                 380                 


Leu Ile Ile Phe Asp Glu Pro Pro Val Asp Lys Thr Tyr Glu Ala Ala 
385                 390                 395                 400 


Leu Glu Thr Ile Gln Asn Met Ser Lys Val Val Asp Ser Leu Tyr Asn 
                405                 410                 415     


Lys Ala Lys Lys Leu Thr 
            420         


<210> 4903
<211> 482
<212> PRT
<213> Homo sapiens

<400> 4903
Met Ala Ser Leu Gly Pro Ala Ala Ala Gly Glu Gln Ala Ser Gly Ala 
1               5                   10                  15      


Glu Ala Glu Pro Gly Pro Ala Gly Pro Pro Pro Pro Pro Ser Pro Ser 
            20                  25                  30          


Ser Leu Gly Pro Leu Leu Pro Leu Gln Arg Glu Pro Leu Tyr Asn Trp 
        35                  40                  45              


Gln Ala Thr Lys Ala Ser Leu Lys Glu Arg Phe Ala Phe Leu Phe Asn 
    50                  55                  60                  


Ser Glu Leu Leu Ser Asp Val Arg Phe Val Leu Gly Lys Gly Arg Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Gly Pro Gln Arg Ile Pro Ala His Arg Phe Val 
                85                  90                  95      


Leu Ala Ala Gly Ser Ala Val Phe Asp Ala Met Phe Asn Gly Gly Met 
            100                 105                 110         


Ala Thr Thr Ser Ala Glu Ile Glu Leu Pro Asp Val Glu Pro Ala Ala 
        115                 120                 125             


Phe Leu Ala Leu Leu Arg Phe Leu Tyr Ser Asp Glu Val Gln Ile Gly 
    130                 135                 140                 


Pro Glu Thr Val Met Thr Thr Leu Tyr Thr Ala Lys Lys Tyr Ala Val 
145                 150                 155                 160 


Pro Ala Leu Glu Ala His Cys Val Glu Phe Leu Thr Lys His Leu Arg 
                165                 170                 175     


Ala Asp Asn Ala Phe Met Leu Leu Thr Gln Ala Arg Leu Phe Asp Glu 
            180                 185                 190         


Pro Gln Leu Ala Ser Leu Cys Leu Asp Thr Ile Asp Lys Ser Thr Met 
        195                 200                 205             


Asp Ala Ile Ser Ala Glu Gly Phe Thr Asp Ile Asp Ile Asp Thr Leu 
    210                 215                 220                 


Cys Ala Val Leu Glu Arg Asp Thr Leu Ser Ile Arg Glu Ser Arg Leu 
225                 230                 235                 240 


Phe Gly Ala Val Val Arg Trp Ala Glu Ala Glu Cys Gln Arg Gln Gln 
                245                 250                 255     


Leu Pro Val Thr Phe Gly Asn Lys Gln Lys Val Leu Gly Lys Ala Leu 
            260                 265                 270         


Ser Leu Ile Arg Phe Pro Leu Met Thr Ile Glu Glu Phe Ala Ala Gly 
        275                 280                 285             


Pro Ala Gln Ser Gly Ile Leu Ser Asp Arg Glu Val Val Asn Leu Phe 
    290                 295                 300                 


Leu His Phe Thr Val Asn Pro Lys Pro Arg Val Glu Tyr Ile Asp Arg 
305                 310                 315                 320 


Pro Arg Cys Cys Leu Arg Gly Lys Glu Cys Cys Ile Asn Arg Phe Gln 
                325                 330                 335     


Gln Val Glu Ser Arg Trp Gly Tyr Ser Gly Thr Ser Asp Arg Ile Arg 
            340                 345                 350         


Phe Thr Val Asn Arg Arg Ile Ser Ile Val Gly Phe Gly Leu Tyr Gly 
        355                 360                 365             


Ser Ile His Gly Pro Thr Asp Tyr Gln Val Asn Ile Gln Ile Ile Glu 
    370                 375                 380                 


Tyr Glu Lys Lys Gln Thr Leu Gly Gln Asn Asp Thr Gly Phe Ser Cys 
385                 390                 395                 400 


Asp Gly Thr Ala Asn Thr Phe Arg Val Met Phe Lys Glu Pro Ile Glu 
                405                 410                 415     


Ile Leu Pro Asn Val Cys Tyr Thr Ala Cys Ala Thr Leu Lys Gly Pro 
            420                 425                 430         


Asp Ser His Tyr Gly Thr Lys Gly Leu Lys Lys Val Val His Glu Thr 
        435                 440                 445             


Pro Ala Ala Ser Lys Thr Val Phe Phe Phe Phe Ser Ser Pro Gly Asn 
    450                 455                 460                 


Asn Asn Gly Thr Ser Ile Glu Asp Gly Gln Ile Pro Glu Ile Ile Phe 
465                 470                 475                 480 


Tyr Thr 
        


<210> 4904
<211> 960
<212> PRT
<213> Homo sapiens

<400> 4904
Met Ser Arg Leu Ile Val Lys Asn Leu Pro Asn Gly Met Lys Glu Glu 
1               5                   10                  15      


Arg Phe Arg Gln Leu Phe Ala Ala Phe Gly Thr Leu Thr Asp Cys Ser 
            20                  25                  30          


Leu Lys Phe Thr Lys Asp Gly Lys Phe Arg Lys Phe Gly Phe Ile Gly 
        35                  40                  45              


Phe Lys Ser Glu Glu Glu Ala Gln Lys Ala Gln Lys His Phe Asn Lys 
    50                  55                  60                  


Ser Phe Ile Asp Thr Ser Arg Ile Thr Val Glu Phe Cys Lys Ser Phe 
65                  70                  75                  80  


Gly Asp Pro Ala Lys Pro Arg Ala Trp Ser Lys His Ala Gln Lys Pro 
                85                  90                  95      


Ser Gln Pro Lys Gln Pro Pro Lys Asp Ser Thr Thr Pro Glu Ile Lys 
            100                 105                 110         


Lys Asp Glu Lys Lys Lys Lys Val Ala Gly Gln Leu Glu Lys Leu Lys 
        115                 120                 125             


Glu Asp Thr Glu Phe Gln Glu Phe Leu Ser Val His Gln Arg Arg Ala 
    130                 135                 140                 


Gln Ala Ala Thr Trp Ala Asn Asp Gly Leu Asp Ala Glu Pro Ser Lys 
145                 150                 155                 160 


Gly Lys Ser Lys Pro Ala Ser Asp Tyr Leu Asn Phe Asp Ser Asp Ser 
                165                 170                 175     


Gly Gln Glu Ser Glu Glu Glu Gly Ala Gly Glu Asp Leu Glu Glu Glu 
            180                 185                 190         


Ala Ser Leu Glu Pro Lys Ala Ala Val Gln Lys Glu Leu Ser Asp Met 
        195                 200                 205             


Asp Tyr Leu Lys Ser Lys Met Val Lys Ala Gly Ser Ser Ser Ser Ser 
    210                 215                 220                 


Glu Glu Glu Glu Ser Glu Asp Glu Ala Val His Cys Asp Glu Gly Ser 
225                 230                 235                 240 


Glu Ala Glu Glu Glu Asp Ser Ser Ala Thr Pro Val Leu Gln Glu Arg 
                245                 250                 255     


Asp Ser Lys Gly Ala Gly Gln Glu Gln Gly Met Pro Ala Gly Lys Lys 
            260                 265                 270         


Arg Pro Pro Glu Ala Arg Ala Glu Thr Glu Lys Pro Ala Asn Gln Lys 
        275                 280                 285             


Glu Pro Thr Thr Cys His Thr Val Lys Leu Arg Gly Ala Pro Phe Asn 
    290                 295                 300                 


Val Thr Glu Lys Asn Val Met Glu Phe Leu Ala Pro Leu Lys Pro Val 
305                 310                 315                 320 


Ala Ile Arg Ile Val Arg Asn Ala His Gly Asn Lys Thr Gly Tyr Ile 
                325                 330                 335     


Phe Val Asp Phe Ser Asn Glu Glu Glu Val Lys Gln Ala Leu Lys Cys 
            340                 345                 350         


Asn Arg Glu Tyr Met Gly Gly Arg Tyr Ile Glu Val Phe Arg Glu Lys 
        355                 360                 365             


Asn Val Pro Thr Thr Lys Gly Ala Pro Lys Asn Thr Thr Lys Ser Trp 
    370                 375                 380                 


Gln Gly Arg Ile Leu Gly Glu Asn Glu Glu Glu Glu Asp Leu Ala Glu 
385                 390                 395                 400 


Ser Gly Arg Leu Phe Val Arg Asn Leu Pro Tyr Thr Ser Thr Glu Glu 
                405                 410                 415     


Asp Leu Glu Lys Leu Phe Ser Lys Tyr Gly Pro Leu Ser Glu Leu His 
            420                 425                 430         


Tyr Pro Ile Asp Ser Leu Thr Lys Lys Pro Lys Gly Phe Ala Phe Ile 
        435                 440                 445             


Thr Phe Met Phe Pro Glu His Ala Val Lys Ala Tyr Ser Glu Val Asp 
    450                 455                 460                 


Gly Gln Val Phe Gln Gly Arg Met Leu His Val Leu Pro Ser Thr Ile 
465                 470                 475                 480 


Lys Lys Glu Ala Ser Glu Asp Ala Ser Ala Leu Gly Ser Ser Ser Tyr 
                485                 490                 495     


Lys Lys Lys Lys Glu Ala Gln Asp Lys Ala Asn Ser Ala Ser Ser His 
            500                 505                 510         


Asn Trp Asn Thr Leu Phe Met Gly Pro Asn Ala Val Ala Asp Ala Ile 
        515                 520                 525             


Ala Gln Lys Tyr Asn Ala Thr Lys Ser Gln Val Phe Asp His Glu Thr 
    530                 535                 540                 


Lys Gly Ser Val Ala Val Arg Val Ala Leu Gly Glu Thr Gln Leu Val 
545                 550                 555                 560 


Gln Glu Val Arg Arg Phe Leu Ile Asp Asn Gly Val Ser Leu Asp Ser 
                565                 570                 575     


Phe Ser Gln Ala Ala Ala Glu Arg Ser Lys Thr Val Ile Leu Val Lys 
            580                 585                 590         


Asn Leu Pro Ala Gly Thr Leu Ala Ala Gln Leu Gln Glu Thr Phe Gly 
        595                 600                 605             


His Phe Gly Ser Leu Gly Arg Val Leu Leu Pro Glu Gly Gly Ile Thr 
    610                 615                 620                 


Ala Ile Val Glu Phe Leu Glu Pro Leu Glu Ala Arg Lys Ala Phe Arg 
625                 630                 635                 640 


His Leu Ala Tyr Ser Lys Phe His His Val Pro Leu Tyr Leu Glu Trp 
                645                 650                 655     


Ala Pro Val Gly Val Phe Ser Ser Thr Ala Pro Gln Lys Lys Lys Leu 
            660                 665                 670         


Gln Asp Thr Pro Ser Glu Pro Met Glu Lys Asp Pro Ala Glu Pro Glu 
        675                 680                 685             


Thr Val Pro Asp Gly Glu Thr Pro Glu Asp Glu Asn Pro Thr Glu Glu 
    690                 695                 700                 


Gly Ala Asp Asn Ser Ser Ala Lys Met Glu Glu Glu Glu Glu Glu Glu 
705                 710                 715                 720 


Glu Glu Glu Glu Glu Ser Leu Pro Gly Cys Thr Leu Phe Ile Lys Asn 
                725                 730                 735     


Leu Asn Phe Asp Thr Thr Glu Glu Lys Leu Lys Glu Val Phe Ser Lys 
            740                 745                 750         


Val Gly Thr Val Lys Ser Cys Ser Ile Ser Lys Lys Lys Asn Lys Ala 
        755                 760                 765             


Gly Val Leu Leu Ser Met Gly Phe Gly Phe Val Glu Tyr Arg Lys Pro 
    770                 775                 780                 


Glu Gln Ala Gln Lys Ala Leu Lys Gln Leu Gln Gly His Val Val Asp 
785                 790                 795                 800 


Gly His Lys Leu Glu Val Arg Ile Ser Glu Arg Ala Thr Lys Pro Ala 
                805                 810                 815     


Val Thr Leu Ala Arg Lys Lys Gln Val Pro Arg Lys Gln Thr Thr Ser 
            820                 825                 830         


Lys Ile Leu Val Arg Asn Ile Pro Phe Gln Ala His Ser Arg Glu Ile 
        835                 840                 845             


Arg Glu Leu Phe Ser Thr Phe Gly Glu Leu Lys Thr Val Arg Leu Pro 
    850                 855                 860                 


Lys Lys Met Thr Gly Thr Gly Thr His Arg Gly Phe Gly Phe Val Asp 
865                 870                 875                 880 


Phe Leu Thr Lys Gln Asp Ala Lys Arg Ala Phe Asn Ala Leu Cys His 
                885                 890                 895     


Ser Thr His Leu Tyr Gly Arg Arg Leu Val Leu Glu Trp Ala Asp Ser 
            900                 905                 910         


Glu Val Thr Leu Gln Ala Leu Arg Arg Lys Thr Ala Ala His Phe His 
        915                 920                 925             


Glu Pro Pro Lys Lys Lys Arg Ser Val Val Leu Asp Glu Ile Leu Glu 
    930                 935                 940                 


Gln Leu Glu Gly Ser Asp Ser Asp Ser Glu Glu Gln Thr Leu Gln Leu 
945                 950                 955                 960 


<210> 4905
<211> 972
<212> PRT
<213> Homo sapiens

<400> 4905
Met Ala Thr Arg Gly His Val Gln Asp Pro Asn Asp Arg Arg Leu Arg 
1               5                   10                  15      


Pro Ile Tyr Asp Tyr Leu Asp Asn Gly Asn Asn Lys Met Ala Ile Gln 
            20                  25                  30          


Gln Ala Asp Lys Leu Leu Lys Lys His Lys Asp Leu His Cys Ala Lys 
        35                  40                  45              


Val Leu Lys Ala Ile Gly Leu Gln Arg Thr Gly Lys Gln Glu Glu Ala 
    50                  55                  60                  


Phe Thr Leu Ala Gln Glu Val Ala Ala Leu Glu Pro Thr Asp Asp Asn 
65                  70                  75                  80  


Ser Leu Gln Ala Leu Thr Ile Leu Tyr Arg Glu Met His Arg Pro Glu 
                85                  90                  95      


Leu Val Thr Lys Leu Tyr Glu Ala Ala Val Lys Lys Val Pro Asn Ser 
            100                 105                 110         


Glu Glu Tyr His Ser His Leu Phe Met Ala Tyr Ala Arg Val Gly Glu 
        115                 120                 125             


Tyr Lys Lys Met Gln Gln Ala Gly Met Ala Leu Tyr Lys Ile Val Pro 
    130                 135                 140                 


Lys Asn Pro Tyr Tyr Phe Trp Ser Val Met Ser Leu Ile Met Gln Ser 
145                 150                 155                 160 


Ile Ser Ala Gln Asp Glu Asn Leu Ser Lys Thr Met Phe Leu Pro Leu 
                165                 170                 175     


Ala Glu Arg Met Val Glu Lys Met Val Lys Glu Asp Lys Ile Glu Ala 
            180                 185                 190         


Glu Ala Glu Val Glu Leu Tyr Tyr Met Ile Leu Glu Arg Leu Gly Lys 
        195                 200                 205             


Tyr Gln Glu Ala Leu Asp Val Ile Arg Gly Lys Leu Gly Glu Lys Leu 
    210                 215                 220                 


Thr Ser Glu Ile Gln Ser Arg Glu Asn Lys Cys Met Ala Met Tyr Lys 
225                 230                 235                 240 


Lys Leu Ser Arg Trp Pro Glu Cys Asn Ala Leu Ser Arg Arg Leu Leu 
                245                 250                 255     


Leu Lys Asn Ser Asp Asp Trp Gln Phe Tyr Leu Thr Tyr Phe Asp Ser 
            260                 265                 270         


Val Phe Arg Leu Ile Glu Glu Ala Trp Ser Pro Pro Ala Glu Gly Glu 
        275                 280                 285             


His Ser Leu Glu Gly Glu Val His Tyr Ser Ala Glu Lys Ala Val Lys 
    290                 295                 300                 


Phe Ile Glu Asp Arg Ile Thr Glu Glu Ser Lys Ser Ser Arg His Leu 
305                 310                 315                 320 


Arg Gly Pro His Leu Ala Lys Leu Glu Leu Ile Arg Arg Leu Arg Ser 
                325                 330                 335     


Gln Gly Cys Asn Asp Glu Tyr Lys Leu Gly Asp Pro Glu Glu Leu Met 
            340                 345                 350         


Phe Gln Tyr Phe Lys Lys Phe Gly Asp Lys Pro Cys Cys Phe Thr Asp 
        355                 360                 365             


Leu Lys Val Phe Val Asp Leu Leu Pro Ala Thr Gln Cys Thr Lys Phe 
    370                 375                 380                 


Ile Asn Gln Leu Leu Gly Val Val Pro Leu Ser Thr Pro Thr Glu Asp 
385                 390                 395                 400 


Lys Leu Ala Leu Pro Ala Asp Ile Arg Ala Leu Gln Gln His Leu Cys 
                405                 410                 415     


Val Val Gln Leu Thr Arg Leu Leu Gly Leu Tyr His Thr Met Asp Lys 
            420                 425                 430         


Asn Gln Lys Leu Ser Val Val Arg Glu Leu Met Leu Arg Tyr Gln His 
        435                 440                 445             


Gly Leu Glu Phe Gly Lys Thr Cys Leu Lys Thr Glu Leu Gln Phe Ser 
    450                 455                 460                 


Asp Tyr Tyr Cys Leu Leu Ala Val His Ala Leu Ile Asp Val Trp Arg 
465                 470                 475                 480 


Glu Thr Gly Asp Glu Thr Thr Val Trp Gln Ala Leu Thr Leu Leu Glu 
                485                 490                 495     


Glu Gly Leu Thr His Ser Pro Ser Asn Ala Gln Phe Lys Leu Leu Leu 
            500                 505                 510         


Val Arg Ile Tyr Cys Met Leu Gly Ala Phe Glu Pro Val Val Asp Leu 
        515                 520                 525             


Tyr Ser Ser Leu Asp Ala Lys His Ile Gln His Asp Thr Ile Gly Tyr 
    530                 535                 540                 


Leu Leu Thr Arg Tyr Ala Glu Ser Leu Gly Gln Tyr Ala Ala Ala Ser 
545                 550                 555                 560 


Gln Ser Cys Asn Phe Ala Leu Arg Phe Phe His Ser Asn Gln Lys Asp 
                565                 570                 575     


Thr Ser Glu Tyr Ile Ile Gln Ala Tyr Lys Tyr Gly Ala Phe Glu Lys 
            580                 585                 590         


Ile Pro Glu Phe Ile Ala Phe Arg Asn Arg Leu Asn Asn Ser Leu His 
        595                 600                 605             


Phe Ala Gln Val Arg Thr Glu Arg Met Leu Leu Asp Leu Leu Leu Glu 
    610                 615                 620                 


Ala Asn Ile Ser Thr Ser Leu Ala Glu Ser Ile Lys Ser Met Asn Leu 
625                 630                 635                 640 


Arg Pro Glu Glu Asp Asp Ile Pro Trp Glu Asp Leu Arg Asp Asn Arg 
                645                 650                 655     


Asp Leu Asn Val Phe Phe Ser Trp Asp Pro Lys Asp Arg Asp Val Ser 
            660                 665                 670         


Glu Glu His Lys Lys Leu Ser Leu Glu Glu Glu Thr Leu Trp Leu Arg 
        675                 680                 685             


Ile Arg Ser Leu Thr Leu Arg Leu Ile Ser Gly Leu Pro Ser Leu Asn 
    690                 695                 700                 


His Pro Val Glu Pro Lys Asn Ser Glu Lys Thr Ala Glu Asn Gly Val 
705                 710                 715                 720 


Ser Ser Arg Ile Asp Ile Leu Arg Leu Leu Leu Gln Gln Leu Glu Ala 
                725                 730                 735     


Thr Leu Glu Thr Gly Lys Arg Phe Ile Glu Lys Asp Ile Gln Tyr Pro 
            740                 745                 750         


Phe Leu Gly Pro Val Pro Thr Arg Met Gly Gly Phe Phe Asn Ser Gly 
        755                 760                 765             


Cys Ser Gln Cys Gln Ile Ser Ser Phe Tyr Leu Val Asn Asp Ile Tyr 
    770                 775                 780                 


Glu Leu Asp Thr Ser Gly Leu Glu Asp Thr Met Glu Ile Gln Glu Arg 
785                 790                 795                 800 


Ile Glu Asn Ser Phe Lys Ser Leu Leu Asp Gln Leu Lys Asp Val Phe 
                805                 810                 815     


Ser Lys Cys Lys Gly Asp Leu Leu Glu Val Lys Asp Gly Asn Leu Lys 
            820                 825                 830         


Thr His Pro Thr Leu Leu Glu Asn Leu Val Phe Phe Val Glu Thr Ile 
        835                 840                 845             


Ser Val Ile Leu Trp Val Ser Ser Tyr Cys Glu Ser Val Leu Arg Pro 
    850                 855                 860                 


Tyr Lys Leu Asn Leu Gln Lys Lys Lys Lys Lys Lys Lys Glu Thr Ser 
865                 870                 875                 880 


Ile Ile Met Pro Pro Val Phe Thr Ser Phe Gln Asp Tyr Val Thr Gly 
                885                 890                 895     


Leu Gln Thr Leu Ile Ser Asn Val Val Asp His Ile Lys Gly Leu Glu 
            900                 905                 910         


Thr His Leu Ile Ala Leu Lys Leu Glu Glu Leu Ile Leu Glu Asp Thr 
        915                 920                 925             


Ser Leu Ser Pro Glu Glu Arg Lys Phe Ser Lys Thr Val Gln Gly Lys 
    930                 935                 940                 


Val Gln Ser Ser Tyr Leu His Ser Leu Leu Glu Met Gly Glu Leu Leu 
945                 950                 955                 960 


Lys Lys Arg Leu Glu Thr Thr Lys Lys Leu Lys Ile 
                965                 970         


<210> 4906
<211> 721
<212> PRT
<213> Homo sapiens

<400> 4906
Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu 
1               5                   10                  15      


Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly 
            20                  25                  30          


Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile 
        35                  40                  45              


Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg 
    50                  55                  60                  


Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val 
65                  70                  75                  80  


Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly 
                85                  90                  95      


Ser Leu Thr Glu Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu 
            100                 105                 110         


Thr Asp Leu Ala Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His 
        115                 120                 125             


Ala Arg Leu Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His 
    130                 135                 140                 


Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile 
145                 150                 155                 160 


Asn Thr Glu Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Ile Met Asp Pro His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu 
            180                 185                 190         


Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn 
        195                 200                 205             


Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu 
    210                 215                 220                 


Met Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln 
225                 230                 235                 240 


Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg 
                245                 250                 255     


Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr 
            260                 265                 270         


Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu 
        275                 280                 285             


Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg 
    290                 295                 300                 


Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser 
305                 310                 315                 320 


Phe Pro Met Asp Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp 
                325                 330                 335     


Glu Val Asp Asp Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr 
            340                 345                 350         


Asn Trp Glu Arg Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro 
        355                 360                 365             


Val His Asn Asn Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala 
    370                 375                 380                 


Leu Ser Asp Val Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys 
385                 390                 395                 400 


Tyr Leu Asp Gly Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp 
                405                 410                 415     


Thr Asn Tyr Ser Thr Glu Pro Cys Trp Gln Tyr Ser Asp His His Glu 
            420                 425                 430         


Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr 
        435                 440                 445             


Arg Ser Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val 
    450                 455                 460                 


Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys 
465                 470                 475                 480 


Glu Gln Ser Lys Glu Lys Ser Asp Lys Lys Gly Lys Ser Lys Cys Glu 
                485                 490                 495     


Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln 
            500                 505                 510         


Gln Leu Ala Gly Lys Glu Arg Glu Lys Asn Gln Gly Phe Asp Phe Asp 
        515                 520                 525             


Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln His Glu Pro Thr 
    530                 535                 540                 


Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu 
545                 550                 555                 560 


Glu Leu Lys Ser Leu Ile Ser Lys Ser Val Ser Gln Glu Lys Gln Glu 
                565                 570                 575     


Lys Gly Met Ala Asn Leu Ala Gln Leu Glu Ala Leu Tyr Gln Ser Ser 
            580                 585                 590         


Trp Asp Ser Gln Phe Val Ser Gly Gly Glu Asp Cys Phe Phe Ile Asn 
        595                 600                 605             


Gln Phe Cys Glu Val Arg Lys Asp Glu Gln Val Glu Lys Glu Asn Thr 
    610                 615                 620                 


Tyr Thr Ser Tyr Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Thr Glu 
625                 630                 635                 640 


Met Leu Glu Thr Glu Pro Val Glu Asp Gly Lys Leu Gly Glu Arg Gly 
                645                 650                 655     


His Glu Glu Gly Phe Leu Asn Asn Ser Gly Glu Phe Leu Phe Asn Lys 
            660                 665                 670         


Gln Leu Glu Ser Ile Gly Ile Pro Gln Phe His Ser Pro Val Gly Ser 
        675                 680                 685             


Pro Leu Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser 
    690                 695                 700                 


Ser Pro Gln Ile Pro His Gln Thr Tyr Ser Ser Ile Leu Lys His Leu 
705                 710                 715                 720 


Asn 
    


<210> 4907
<211> 315
<212> PRT
<213> Homo sapiens

<400> 4907
Met Ala Ala Gly Val Pro Cys Ala Leu Val Thr Ser Cys Ser Ser Val 
1               5                   10                  15      


Phe Ser Gly Asp Gln Leu Val Gln His Ile Leu Gly Thr Glu Asp Leu 
            20                  25                  30          


Ile Val Glu Val Thr Ser Asn Asp Ala Val Arg Phe Tyr Pro Trp Thr 
        35                  40                  45              


Ile Asp Asn Lys Tyr Tyr Ser Ala Asp Ile Asn Leu Cys Val Val Pro 
    50                  55                  60                  


Asn Lys Phe Leu Val Thr Ala Glu Ile Ala Glu Ser Val Gln Ala Phe 
65                  70                  75                  80  


Val Val Tyr Phe Asp Ser Thr Gln Lys Ser Gly Leu Asp Ser Val Ser 
                85                  90                  95      


Ser Trp Leu Pro Leu Ala Lys Ala Trp Leu Pro Glu Val Met Ile Leu 
            100                 105                 110         


Val Cys Asp Arg Val Ser Glu Asp Gly Ile Asn Arg Gln Lys Ala Gln 
        115                 120                 125             


Glu Trp Cys Ile Lys His Gly Phe Glu Leu Val Glu Leu Ser Pro Glu 
    130                 135                 140                 


Glu Leu Pro Glu Glu Asp Asp Asp Phe Pro Glu Ser Thr Gly Val Lys 
145                 150                 155                 160 


Arg Ile Val Gln Ala Leu Asn Ala Asn Val Trp Ser Asn Val Val Met 
                165                 170                 175     


Lys Asn Asp Arg Asn Gln Gly Phe Ser Leu Leu Asn Ser Leu Thr Gly 
            180                 185                 190         


Thr Asn His Ser Ile Gly Ser Ala Asp Pro Cys His Pro Glu Gln Pro 
        195                 200                 205             


His Leu Pro Ala Ala Asp Ser Thr Glu Ser Leu Ser Asp His Arg Gly 
    210                 215                 220                 


Gly Ala Ser Asn Thr Thr Asp Ala Gln Val Asp Ser Ile Val Asp Pro 
225                 230                 235                 240 


Met Leu Asp Leu Asp Ile Gln Glu Leu Ala Ser Leu Thr Thr Gly Gly 
                245                 250                 255     


Gly Asp Val Glu Asn Phe Glu Arg Leu Phe Ser Lys Leu Lys Glu Met 
            260                 265                 270         


Lys Asp Lys Ala Ala Thr Leu Pro His Glu Gln Arg Lys Val His Ala 
        275                 280                 285             


Glu Lys Val Ala Lys Ala Phe Trp Met Ala Ile Gly Gly Asp Arg Asp 
    290                 295                 300                 


Glu Ile Glu Gly Leu Ser Ser Asp Glu Glu His 
305                 310                 315 


<210> 4908
<211> 445
<212> PRT
<213> Homo sapiens

<400> 4908
Met Ala Ala Pro Glu Glu Arg Asp Leu Thr Gln Glu Gln Thr Glu Lys 
1               5                   10                  15      


Leu Leu Gln Phe Gln Asp Leu Thr Gly Ile Glu Ser Met Asp Gln Cys 
            20                  25                  30          


Arg His Thr Leu Glu Gln His Asn Trp Asn Ile Glu Ala Ala Val Gln 
        35                  40                  45              


Asp Arg Leu Asn Glu Gln Glu Gly Val Pro Ser Val Phe Asn Pro Pro 
    50                  55                  60                  


Pro Ser Arg Pro Leu Gln Val Asn Thr Ala Asp His Arg Ile Tyr Ser 
65                  70                  75                  80  


Tyr Val Val Ser Arg Pro Gln Pro Arg Gly Leu Leu Gly Trp Gly Tyr 
                85                  90                  95      


Tyr Leu Ile Met Leu Pro Phe Arg Phe Thr Tyr Tyr Thr Ile Leu Asp 
            100                 105                 110         


Ile Phe Arg Phe Ala Leu Arg Phe Ile Arg Pro Asp Pro Arg Ser Arg 
        115                 120                 125             


Val Thr Asp Pro Val Gly Asp Ile Val Ser Phe Met His Ser Phe Glu 
    130                 135                 140                 


Glu Lys Tyr Gly Arg Ala His Pro Val Phe Tyr Gln Gly Thr Tyr Ser 
145                 150                 155                 160 


Gln Ala Leu Asn Asp Ala Lys Arg Glu Leu Arg Phe Leu Leu Val Tyr 
                165                 170                 175     


Leu His Gly Asp Asp His Gln Asp Ser Asp Glu Phe Cys Arg Asn Thr 
            180                 185                 190         


Leu Cys Ala Pro Glu Val Ile Ser Leu Ile Asn Thr Arg Met Leu Phe 
        195                 200                 205             


Trp Ala Cys Ser Thr Asn Lys Pro Glu Gly Tyr Arg Val Ser Gln Ala 
    210                 215                 220                 


Leu Arg Glu Asn Thr Tyr Pro Phe Leu Ala Met Ile Met Leu Lys Asp 
225                 230                 235                 240 


Arg Arg Met Thr Val Val Gly Arg Leu Glu Gly Leu Ile Gln Pro Asp 
                245                 250                 255     


Asp Leu Ile Asn Gln Leu Thr Phe Ile Met Asp Ala Asn Gln Thr Tyr 
            260                 265                 270         


Leu Val Ser Glu Arg Leu Glu Arg Glu Glu Arg Asn Gln Thr Gln Val 
        275                 280                 285             


Leu Arg Gln Gln Gln Asp Glu Ala Tyr Leu Ala Ser Leu Arg Ala Asp 
    290                 295                 300                 


Gln Glu Lys Glu Arg Lys Lys Arg Glu Glu Arg Glu Arg Lys Arg Arg 
305                 310                 315                 320 


Lys Glu Glu Glu Val Gln Gln Gln Lys Leu Ala Glu Glu Arg Arg Arg 
                325                 330                 335     


Gln Asn Leu Gln Glu Glu Lys Glu Arg Lys Leu Glu Cys Leu Pro Pro 
            340                 345                 350         


Glu Pro Ser Pro Asp Asp Pro Glu Ser Val Lys Ile Ile Phe Lys Leu 
        355                 360                 365             


Pro Asn Asp Ser Arg Val Glu Arg Arg Phe His Phe Ser Gln Ser Leu 
    370                 375                 380                 


Thr Val Ile His Asp Phe Leu Phe Ser Leu Lys Glu Ser Pro Glu Lys 
385                 390                 395                 400 


Phe Gln Ile Glu Ala Asn Phe Pro Arg Arg Val Leu Pro Cys Ile Pro 
                405                 410                 415     


Ser Glu Glu Trp Pro Asn Pro Pro Thr Leu Gln Glu Ala Gly Leu Ser 
            420                 425                 430         


His Thr Glu Val Leu Phe Val Gln Asp Leu Thr Asp Glu 
        435                 440                 445 


<210> 4909
<211> 907
<212> PRT
<213> Homo sapiens

<400> 4909
Met Ala Thr Pro Asp Gln Lys Ser Pro Asn Val Leu Leu Gln Asn Leu 
1               5                   10                  15      


Cys Cys Arg Ile Leu Gly Arg Ser Glu Ala Asp Val Ala Gln Gln Phe 
            20                  25                  30          


Gln Tyr Ala Val Arg Val Ile Gly Ser Asn Phe Ala Pro Thr Val Glu 
        35                  40                  45              


Arg Asp Glu Phe Leu Val Ala Glu Lys Ile Lys Lys Glu Leu Ile Arg 
    50                  55                  60                  


Gln Arg Arg Glu Ala Asp Ala Ala Leu Phe Ser Glu Leu His Arg Lys 
65                  70                  75                  80  


Leu His Ser Gln Gly Val Leu Lys Asn Lys Trp Ser Ile Leu Tyr Leu 
                85                  90                  95      


Leu Leu Ser Leu Ser Glu Asp Pro Arg Arg Gln Pro Ser Lys Val Ser 
            100                 105                 110         


Ser Tyr Ala Thr Leu Phe Ala Gln Ala Leu Pro Arg Asp Ala His Ser 
        115                 120                 125             


Thr Pro Tyr Tyr Tyr Ala Arg Pro Gln Thr Leu Pro Leu Ser Tyr Gln 
    130                 135                 140                 


Asp Arg Ser Ala Gln Ser Ala Gln Ser Ser Gly Ser Val Gly Ser Ser 
145                 150                 155                 160 


Gly Ile Ser Ser Ile Gly Leu Cys Ala Leu Ser Gly Pro Ala Pro Ala 
                165                 170                 175     


Pro Gln Ser Leu Leu Pro Gly Gln Ser Asn Gln Ala Pro Gly Val Gly 
            180                 185                 190         


Asp Cys Leu Arg Gln Gln Leu Gly Ser Arg Leu Ala Trp Thr Leu Thr 
        195                 200                 205             


Ala Asn Gln Pro Ser Ser Gln Ala Thr Thr Ser Lys Gly Val Pro Ser 
    210                 215                 220                 


Ala Val Ser Arg Asn Met Thr Arg Ser Arg Arg Glu Gly Asp Thr Gly 
225                 230                 235                 240 


Gly Thr Met Glu Ile Thr Glu Ala Ala Leu Val Arg Asp Ile Leu Tyr 
                245                 250                 255     


Val Phe Gln Gly Ile Asp Gly Lys Asn Ile Lys Met Asn Asn Thr Glu 
            260                 265                 270         


Asn Cys Tyr Lys Val Glu Gly Lys Ala Asn Leu Ser Arg Ser Leu Arg 
        275                 280                 285             


Asp Thr Ala Val Arg Leu Ser Glu Leu Gly Trp Leu His Asn Lys Ile 
    290                 295                 300                 


Arg Arg Tyr Thr Asp Gln Arg Ser Leu Asp Arg Ser Phe Gly Leu Val 
305                 310                 315                 320 


Gly Gln Ser Phe Cys Ala Ala Leu His Gln Glu Leu Arg Glu Tyr Tyr 
                325                 330                 335     


Arg Leu Leu Ser Val Leu His Ser Gln Leu Gln Leu Glu Asp Asp Gln 
            340                 345                 350         


Gly Val Asn Leu Gly Leu Glu Ser Ser Leu Thr Leu Arg Arg Leu Leu 
        355                 360                 365             


Val Trp Thr Tyr Asp Pro Lys Ile Arg Leu Lys Thr Leu Ala Ala Leu 
    370                 375                 380                 


Val Asp His Cys Gln Gly Arg Lys Gly Gly Glu Leu Ala Ser Ala Val 
385                 390                 395                 400 


His Ala Tyr Thr Lys Thr Gly Asp Pro Tyr Met Arg Ser Leu Val Gln 
                405                 410                 415     


His Ile Leu Ser Leu Val Ser His Pro Val Leu Ser Phe Leu Tyr Arg 
            420                 425                 430         


Trp Ile Tyr Asp Gly Glu Leu Glu Asp Thr Tyr His Glu Phe Phe Val 
        435                 440                 445             


Ala Ser Asp Pro Thr Val Lys Thr Asp Arg Leu Trp His Asp Lys Tyr 
    450                 455                 460                 


Thr Leu Arg Lys Ser Met Ile Pro Ser Phe Met Thr Met Asp Gln Ser 
465                 470                 475                 480 


Arg Lys Val Leu Leu Ile Gly Lys Ser Ile Asn Phe Leu His Gln Val 
                485                 490                 495     


Cys His Asp Gln Thr Pro Thr Thr Lys Met Ile Ala Val Thr Lys Ser 
            500                 505                 510         


Ala Glu Ser Pro Gln Asp Ala Ala Asp Leu Phe Thr Asp Leu Glu Asn 
        515                 520                 525             


Ala Phe Gln Gly Lys Ile Asp Ala Ala Tyr Phe Glu Thr Ser Lys Tyr 
    530                 535                 540                 


Leu Leu Asp Val Leu Asn Lys Lys Tyr Ser Leu Leu Asp His Met Gln 
545                 550                 555                 560 


Ala Met Arg Arg Tyr Leu Leu Leu Gly Gln Gly Asp Phe Ile Arg His 
                565                 570                 575     


Leu Met Asp Leu Leu Lys Pro Glu Leu Val Arg Pro Ala Thr Thr Leu 
            580                 585                 590         


Tyr Gln His Asn Leu Thr Gly Ile Leu Glu Thr Ala Val Arg Ala Thr 
        595                 600                 605             


Asn Ala Gln Phe Asp Ser Pro Glu Ile Leu Arg Arg Leu Asp Val Arg 
    610                 615                 620                 


Leu Leu Glu Val Ser Pro Gly Asp Thr Gly Trp Asp Val Phe Ser Leu 
625                 630                 635                 640 


Asp Tyr His Val Asp Gly Pro Ile Ala Thr Val Phe Thr Arg Glu Cys 
                645                 650                 655     


Met Ser His Tyr Leu Arg Val Phe Asn Phe Leu Trp Arg Ala Lys Arg 
            660                 665                 670         


Met Glu Tyr Ile Leu Thr Asp Ile Arg Lys Gly His Met Cys Asn Ala 
        675                 680                 685             


Lys Leu Leu Arg Asn Met Pro Glu Phe Ser Gly Val Leu His Gln Cys 
    690                 695                 700                 


His Ile Leu Ala Ser Glu Met Val His Phe Ile His Gln Met Gln Tyr 
705                 710                 715                 720 


Tyr Ile Thr Phe Glu Val Leu Glu Cys Ser Trp Asp Glu Leu Trp Asn 
                725                 730                 735     


Lys Val Gln Gln Ala Gln Asp Leu Asp His Ile Ile Ala Ala His Glu 
            740                 745                 750         


Val Phe Leu Asp Thr Ile Ile Ser Arg Cys Leu Leu Asp Ser Asp Ser 
        755                 760                 765             


Arg Ala Leu Leu Asn Gln Leu Arg Ala Val Phe Asp Gln Ile Ile Glu 
    770                 775                 780                 


Leu Gln Asn Ala Gln Asp Ala Ile Tyr Arg Ala Ala Leu Glu Glu Leu 
785                 790                 795                 800 


Gln Arg Arg Leu Gln Phe Glu Glu Lys Lys Lys Gln Arg Glu Ile Glu 
                805                 810                 815     


Gly Gln Trp Gly Val Thr Ala Ala Glu Glu Glu Glu Glu Asn Lys Arg 
            820                 825                 830         


Ile Gly Glu Phe Lys Glu Ser Ile Pro Lys Met Cys Ser Gln Leu Arg 
        835                 840                 845             


Ile Leu Thr His Phe Tyr Gln Gly Ile Val Gln Gln Phe Leu Val Leu 
    850                 855                 860                 


Leu Thr Thr Ser Ser Asp Glu Ser Leu Arg Phe Leu Ser Phe Arg Leu 
865                 870                 875                 880 


Asp Phe Asn Glu His Tyr Lys Ala Arg Glu Pro Arg Leu Arg Val Ser 
                885                 890                 895     


Leu Gly Thr Arg Gly Arg Arg Ser Ser His Thr 
            900                 905         


<210> 4910
<211> 361
<212> PRT
<213> Homo sapiens

<400> 4910
Met Thr Gly Lys Ala Gly Glu Ala Leu Ser Lys Pro Lys Ser Glu Thr 
1               5                   10                  15      


Val Ala Lys Ser Thr Ser Gly Gly Ala Pro Ala Arg Cys Thr Gly Phe 
            20                  25                  30          


Gly Ile Gln Glu Ile Leu Gly Leu Asn Lys Glu Pro Pro Ser Ser His 
        35                  40                  45              


Pro Arg Ala Ala Leu Asp Gly Leu Ala Pro Gly His Leu Leu Ala Ala 
    50                  55                  60                  


Arg Ser Val Leu Ser Pro Ala Gly Val Gly Gly Met Gly Leu Leu Gly 
65                  70                  75                  80  


Pro Gly Gly Leu Pro Gly Phe Tyr Thr Gln Pro Thr Phe Leu Glu Val 
                85                  90                  95      


Leu Ser Asp Pro Gln Ser Val His Leu Gln Pro Leu Gly Arg Ala Ser 
            100                 105                 110         


Gly Pro Leu Asp Thr Ser Gln Thr Ala Ser Ser Asp Ser Glu Asp Val 
        115                 120                 125             


Ser Ser Ser Asp Arg Lys Met Ser Lys Ser Ala Leu Asn Gln Thr Lys 
    130                 135                 140                 


Lys Arg Lys Lys Arg Arg His Arg Thr Ile Phe Thr Ser Tyr Gln Leu 
145                 150                 155                 160 


Glu Glu Leu Glu Lys Ala Phe Asn Glu Ala His Tyr Pro Asp Val Tyr 
                165                 170                 175     


Ala Arg Glu Met Leu Ala Met Lys Thr Glu Leu Pro Glu Asp Arg Ile 
            180                 185                 190         


Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg Glu Lys 
        195                 200                 205             


Cys Trp Gly Arg Ser Ser Val Met Ala Glu Tyr Gly Leu Tyr Gly Ala 
    210                 215                 220                 


Met Val Arg His Ser Ile Pro Leu Pro Glu Ser Ile Leu Lys Ser Ala 
225                 230                 235                 240 


Lys Asp Gly Ile Met Asp Ser Cys Ala Pro Trp Leu Leu Gly Met His 
                245                 250                 255     


Lys Lys Ser Leu Glu Ala Ala Ala Glu Ser Gly Arg Lys Pro Glu Gly 
            260                 265                 270         


Glu Arg Gln Ala Leu Pro Lys Leu Asp Lys Met Glu Gln Asp Glu Arg 
        275                 280                 285             


Gly Pro Asp Ala Gln Ala Ala Ile Ser Gln Glu Glu Leu Arg Glu Asn 
    290                 295                 300                 


Ser Ile Ala Val Leu Arg Ala Lys Ala Gln Glu His Ser Thr Lys Val 
305                 310                 315                 320 


Leu Gly Thr Val Ser Gly Pro Asp Ser Leu Ala Arg Ser Thr Glu Lys 
                325                 330                 335     


Pro Glu Glu Glu Glu Ala Met Asp Glu Asp Arg Pro Ala Glu Arg Leu 
            340                 345                 350         


Ser Pro Pro Gln Leu Glu Asp Met Ala 
        355                 360     


<210> 4911
<211> 690
<212> PRT
<213> Homo sapiens

<400> 4911
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Thr Tyr Ile Pro Asn Thr Lys Val Glu Cys 
            20                  25                  30          


His Tyr Thr Leu Pro Pro Gly Thr Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Thr Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Thr Thr Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Thr Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Thr Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Thr Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Thr Glu 
                165                 170                 175     


Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Thr Ala Arg 
            180                 185                 190         


Gln Glu His Thr Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser 
        195                 200                 205             


His Gly Glu Ile Thr Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly 
    210                 215                 220                 


Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Thr Ile 
225                 230                 235                 240 


Ser Glu Lys Val Leu Thr Lys Glu Val Glu Leu Asp Arg Leu Arg Asp 
                245                 250                 255     


Thr Val Lys Ala Leu Thr Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu 
            260                 265                 270         


Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Gln Val 
        275                 280                 285             


Ala Gln Gln Glu Asn His His Leu Asn Leu Asp Leu Lys Glu Ala Lys 
    290                 295                 300                 


Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln Arg Leu Lys Asp Lys 
305                 310                 315                 320 


Val Ala Gln Met Lys Asp Thr Leu Gly Gln Ala Gln Gln Arg Val Ala 
                325                 330                 335     


Glu Leu Glu Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala 
            340                 345                 350         


Ala Ser Ser Gln Gln Lys Ala Thr Leu Leu Gly Glu Glu Leu Ala Ser 
        355                 360                 365             


Ala Ala Ala Ala Arg Asp Arg Thr Ile Ala Glu Leu His Arg Ser Arg 
    370                 375                 380                 


Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His 
385                 390                 395                 400 


Leu Lys Glu Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu 
                405                 410                 415     


Gln Ser Val Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu 
            420                 425                 430         


Ile Leu Arg Leu Glu Lys Ala Val Gln Glu Glu Arg Thr Gln Asn Gln 
        435                 440                 445             


Val Phe Lys Thr Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln 
    450                 455                 460                 


Leu Ser Glu Ser Lys Arg Glu Leu Thr Glu Leu Arg Ser Ala Leu Arg 
465                 470                 475                 480 


Val Leu Gln Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu 
                485                 490                 495     


Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp 
            500                 505                 510         


Glu Lys Trp Asn Glu Asp Ala Thr Thr Glu Asp Glu Glu Ala Ala Val 
        515                 520                 525             


Gly Leu Ser Cys Pro Ala Ala Leu Thr Asp Ser Glu Asp Glu Ser Pro 
    530                 535                 540                 


Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro 
545                 550                 555                 560 


Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile 
                565                 570                 575     


Ser Gln Pro Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp 
            580                 585                 590         


Ser Ser Ser Asp Ser Ala Glu Asp Glu Lys Ser Val Leu Met Ala Ala 
        595                 600                 605             


Val Gln Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu Gly 
    610                 615                 620                 


Ser Ala Phe Tyr Asp Met Ala Ser Gly Phe Thr Val Gly Thr Leu Ser 
625                 630                 635                 640 


Glu Thr Ser Thr Gly Gly Pro Ala Thr Pro Thr Trp Lys Glu Cys Pro 
                645                 650                 655     


Ile Cys Lys Glu Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala Leu Glu 
            660                 665                 670         


Asp His Met Asp Gly His Phe Phe Phe Ser Thr Gln Asp Pro Phe Thr 
        675                 680                 685             


Phe Glu 
    690 


<210> 4912
<211> 659
<212> PRT
<213> Homo sapiens

<400> 4912
Met Ser Leu Pro Pro Glu Lys Ala Ser Glu Leu Lys Gln Leu Ile His 
1               5                   10                  15      


Gln Gln Leu Ser Lys Met Asp Val His Gly Arg Ile Arg Glu Ile Leu 
            20                  25                  30          


Ala Glu Thr Ile Arg Glu Glu Leu Ala Pro Asp Gln Gln His Leu Ser 
        35                  40                  45              


Thr Glu Asp Leu Ile Lys Ala Leu Arg Arg Arg Gly Ile Ile Asp Asp 
    50                  55                  60                  


Val Met Lys Glu Leu Asn Phe Val Thr Asp Ser Val Glu Gln Glu Leu 
65                  70                  75                  80  


Pro Ser Ser Pro Lys Gln Pro Ile Cys Phe Asp Arg Gln Ser Thr Leu 
                85                  90                  95      


Lys Lys Thr Asn Ile Asp Pro Thr Arg Arg Tyr Leu Tyr Leu Gln Val 
            100                 105                 110         


Leu Gly Gly Lys Ala Phe Leu Glu His Leu Gln Glu Pro Glu Pro Leu 
        115                 120                 125             


Pro Gly Gln Val Cys Ser Thr Phe Thr Leu Cys Leu His Tyr Arg Asn 
    130                 135                 140                 


Gln Arg Phe Arg Ser Lys Pro Val Pro Cys Ala Cys Glu Pro Asp Phe 
145                 150                 155                 160 


His Asp Gly Phe Leu Leu Glu Val His Arg Glu Ser Leu Gly Asp Gly 
                165                 170                 175     


Thr Arg Met Ala Asp Ser Thr Thr Met Leu Ser Ile Ser Asp Pro Ile 
            180                 185                 190         


His Met Val Leu Ile Lys Thr Asp Ile Phe Gly Glu Thr Thr Leu Val 
        195                 200                 205             


Ala Ser Tyr Phe Leu Glu Trp Arg Ser Val Leu Gly Ser Glu Asn Gly 
    210                 215                 220                 


Val Thr Ser Leu Thr Val Glu Leu Met Gly Val Gly Thr Glu Ser Lys 
225                 230                 235                 240 


Val Ser Val Gly Ile Leu Asn Ile Lys Leu Glu Met Tyr Pro Pro Leu 
                245                 250                 255     


Asn Gln Thr Leu Ser Gln Glu Val Val Asn Thr Gln Leu Ala Leu Glu 
            260                 265                 270         


Arg Gln Lys Thr Ala Glu Lys Glu Arg Leu Phe Leu Val Tyr Ala Lys 
        275                 280                 285             


Gln Trp Trp Arg Glu Tyr Leu Gln Ile Arg Pro Ser His Asn Ser Arg 
    290                 295                 300                 


Leu Val Lys Ile Phe Ala Gln Asp Glu Asn Gly Ile Asn Arg Pro Val 
305                 310                 315                 320 


Cys Ser Tyr Val Lys Pro Leu Arg Ala Gly Arg Leu Leu Asp Thr Pro 
                325                 330                 335     


Arg Gln Ala Ala Arg Phe Val Asn Val Leu Gly Tyr Glu Arg Ala Pro 
            340                 345                 350         


Val Ile Gly Gly Gly Gly Lys Gln Glu Gln Trp Cys Thr Leu Leu Ala 
        355                 360                 365             


Phe Leu Cys Arg Asn Lys Gly Asp Cys Glu Asp His Ala Asn Leu Leu 
    370                 375                 380                 


Cys Ser Leu Leu Leu Gly Tyr Gly Leu Glu Ala Phe Val Cys Val Gly 
385                 390                 395                 400 


Thr Lys Ala Lys Gly Val Pro His Ala Trp Val Met Thr Cys Gly Thr 
                405                 410                 415     


Asp Gly Ala Ile Thr Phe Trp Glu Ser Leu Thr Gly His Arg Tyr Ile 
            420                 425                 430         


His Lys Pro Thr Asn Pro Asp Glu Pro Pro Val Ala Glu Gln Pro Lys 
        435                 440                 445             


Pro Leu Tyr Pro Tyr Arg Thr Ile Gly Cys Val Phe Asn His Gln Met 
    450                 455                 460                 


Phe Leu Gly Asn Cys Gln Pro Ser Asp Ala Val Glu Thr Cys Val Phe 
465                 470                 475                 480 


Asp Leu Asn Asp Glu Ser Lys Trp Lys Pro Met Ser Glu Glu Ala Ile 
                485                 490                 495     


Lys Ser Val Cys Ala Pro Gly Ala Thr Thr Ser Leu Pro Pro Phe Pro 
            500                 505                 510         


Pro Leu Cys Ala Ser Thr Ile Asp Ala Ser Val Thr Ser Asn Glu Ile 
        515                 520                 525             


Glu Met Gln Leu Arg Leu Leu Val Ser Glu His Arg Lys Asp Leu Gly 
    530                 535                 540                 


Leu Thr Thr Val Trp Glu Asp Gln Leu Ser Tyr Leu Leu Ser Pro Ala 
545                 550                 555                 560 


Leu Ala Ser Tyr Glu Phe Glu Arg Thr Thr Ser Ile Ser Ala Gly Asn 
                565                 570                 575     


Glu Glu Phe Gln Asp Ala Ile Arg Arg Ala Val Pro Asp Gly His Thr 
            580                 585                 590         


Phe Lys Gly Phe Pro Ile His Phe Val Tyr Arg Asn Ala Arg Arg Ala 
        595                 600                 605             


Phe Ala Thr Cys Leu Arg Ser Pro Phe Cys Glu Glu Ile Ile Cys Cys 
    610                 615                 620                 


Arg Gly Asp Gln Val Arg Leu Ala Val Arg Val Arg Val Phe Thr Tyr 
625                 630                 635                 640 


Pro Glu Ser Ala Cys Ala Val Trp Ile Met Phe Ala Cys Lys Tyr Arg 
                645                 650                 655     


Ser Val Leu 
            


<210> 4913
<211> 499
<212> PRT
<213> Homo sapiens

<400> 4913
Met Leu Glu Arg Pro Pro Ala Leu Ala Met Pro Met Pro Thr Glu Gly 
1               5                   10                  15      


Thr Pro Pro Pro Leu Ser Gly Thr Pro Ile Pro Val Pro Ala Tyr Phe 
            20                  25                  30          


Arg His Ala Glu Pro Gly Phe Ser Leu Lys Arg Pro Arg Gly Leu Ser 
        35                  40                  45              


Arg Ser Leu Pro Pro Pro Pro Pro Ala Lys Gly Ser Ile Pro Ile Ser 
    50                  55                  60                  


Arg Leu Phe Pro Pro Arg Thr Pro Gly Trp His Gln Leu Gln Pro Arg 
65                  70                  75                  80  


Arg Val Ser Phe Arg Gly Glu Ala Ser Glu Thr Leu Gln Ser Pro Gly 
                85                  90                  95      


Tyr Asp Pro Ser Arg Pro Glu Ser Phe Phe Gln Gln Ser Phe Gln Arg 
            100                 105                 110         


Leu Ser Arg Leu Gly His Gly Ser Tyr Gly Glu Val Phe Lys Val Arg 
        115                 120                 125             


Ser Lys Glu Asp Gly Arg Leu Tyr Ala Val Lys Arg Ser Met Ser Pro 
    130                 135                 140                 


Phe Arg Gly Pro Lys Asp Arg Ala Arg Lys Leu Ala Glu Val Gly Ser 
145                 150                 155                 160 


His Glu Lys Val Gly Gln His Pro Cys Cys Val Arg Leu Glu Gln Ala 
                165                 170                 175     


Trp Glu Glu Gly Gly Ile Leu Tyr Leu Gln Thr Glu Leu Cys Gly Pro 
            180                 185                 190         


Ser Leu Gln Gln His Cys Glu Ala Trp Gly Ala Ser Leu Pro Glu Ala 
        195                 200                 205             


Gln Val Trp Gly Tyr Leu Arg Asp Thr Leu Leu Ala Leu Ala His Leu 
    210                 215                 220                 


His Ser Gln Gly Leu Val His Leu Asp Val Lys Pro Ala Asn Ile Phe 
225                 230                 235                 240 


Leu Gly Pro Arg Gly Arg Cys Lys Leu Gly Asp Phe Gly Leu Leu Val 
                245                 250                 255     


Glu Leu Gly Thr Ala Gly Ala Gly Glu Val Gln Glu Gly Asp Pro Arg 
            260                 265                 270         


Tyr Met Ala Pro Glu Leu Leu Gln Gly Ser Tyr Gly Thr Ala Ala Asp 
        275                 280                 285             


Val Phe Ser Leu Gly Leu Thr Ile Leu Glu Val Ala Cys Asn Met Glu 
    290                 295                 300                 


Leu Pro His Gly Gly Glu Gly Trp Gln Gln Leu Arg Gln Gly Tyr Leu 
305                 310                 315                 320 


Pro Pro Glu Phe Thr Ala Gly Leu Ser Ser Glu Leu Arg Ser Val Leu 
                325                 330                 335     


Val Met Met Leu Glu Pro Asp Pro Lys Leu Arg Ala Thr Ala Glu Ala 
            340                 345                 350         


Leu Leu Ala Leu Pro Val Leu Arg Gln Pro Arg Ala Trp Gly Val Leu 
        355                 360                 365             


Trp Cys Met Ala Ala Glu Ala Leu Ser Arg Gly Trp Ala Leu Trp Gln 
    370                 375                 380                 


Ala Leu Leu Ala Leu Leu Cys Trp Leu Trp His Gly Leu Ala His Pro 
385                 390                 395                 400 


Ala Ser Trp Leu Gln Pro Leu Gly Pro Pro Ala Thr Pro Pro Gly Ser 
                405                 410                 415     


Pro Pro Cys Ser Leu Leu Leu Asp Ser Ser Leu Ser Ser Asn Trp Asp 
            420                 425                 430         


Asp Asp Ser Leu Gly Pro Ser Leu Ser Pro Glu Ala Val Leu Ala Arg 
        435                 440                 445             


Thr Val Gly Ser Thr Ser Thr Pro Arg Ser Arg Cys Thr Pro Arg Asp 
    450                 455                 460                 


Ala Leu Asp Leu Ser Asp Ile Asn Ser Glu Pro Pro Arg Gly Ser Phe 
465                 470                 475                 480 


Pro Ser Phe Glu Pro Arg Asn Leu Leu Ser Leu Phe Glu Asp Thr Leu 
                485                 490                 495     


Asp Pro Thr 
            


<210> 4914
<211> 161
<212> PRT
<213> Homo sapiens

<400> 4914
Met Asp Val Phe Leu Met Ile Arg Arg His Lys Thr Thr Ile Phe Thr 
1               5                   10                  15      


Asp Ala Lys Glu Ser Ser Thr Val Phe Glu Leu Lys Arg Ile Val Glu 
            20                  25                  30          


Gly Ile Leu Lys Arg Pro Pro Asp Glu Gln Arg Leu Tyr Lys Asp Asp 
        35                  40                  45              


Gln Leu Leu Asp Asp Gly Lys Thr Leu Gly Glu Cys Gly Phe Thr Ser 
    50                  55                  60                  


Gln Thr Ala Arg Pro Gln Ala Pro Ala Thr Val Gly Leu Ala Phe Arg 
65                  70                  75                  80  


Ala Asp Asp Thr Phe Glu Ala Leu Cys Ile Glu Pro Phe Ser Ser Pro 
                85                  90                  95      


Pro Glu Leu Pro Asp Val Met Lys Pro Gln Asp Ser Gly Ser Ser Ala 
            100                 105                 110         


Asn Glu Gln Ala Val His Leu His Val His Ser Gln Thr Met Ala Lys 
        115                 120                 125             


Ser Arg Asn Thr Ser Trp Ser Gln Cys Pro Gly Leu Thr Ala Cys Ser 
    130                 135                 140                 


Thr Arg Glu Pro Gln Asp Gly Pro Thr Gln Val His Pro Arg Trp Gly 
145                 150                 155                 160 


Leu 
    


<210> 4915
<211> 506
<212> PRT
<213> Homo sapiens

<400> 4915
Met Thr Gly Glu Lys Ile Arg Ser Leu Arg Arg Asp His Lys Pro Ser 
1               5                   10                  15      


Lys Glu Glu Gly Asp Leu Leu Glu Pro Gly Asp Glu Glu Ala Ala Ala 
            20                  25                  30          


Ala Leu Gly Gly Thr Phe Thr Arg Ser Arg Ile Gly Lys Gly Gly Lys 
        35                  40                  45              


Ala Cys His Lys Ile Phe Ser Asn His His His Arg Leu Gln Leu Lys 
    50                  55                  60                  


Ala Ala Pro Ala Ser Ser Asn Pro Pro Gly Ala Pro Ala Leu Pro Leu 
65                  70                  75                  80  


His Asn Ser Ser Val Thr Ala Asn Ser Gln Ser Pro Ala Leu Leu Ala 
                85                  90                  95      


Gly Thr Asn Pro Val Ala Val Val Ala Asp Gly Gly Ser Cys Pro Ala 
            100                 105                 110         


His Tyr Pro Val His Glu Cys Val Phe Lys Gly Asp Val Arg Arg Leu 
        115                 120                 125             


Ser Ser Leu Ile Arg Thr His Asn Ile Gly Gln Lys Asp Asn His Gly 
    130                 135                 140                 


Asn Thr Pro Leu His Leu Ala Val Met Leu Gly Asn Lys Val Thr Ala 
145                 150                 155                 160 


Leu Leu Arg Lys Leu Lys Gln Gln Ser Arg Glu Ser Val Glu Glu Lys 
                165                 170                 175     


Arg Pro Arg Leu Leu Lys Ala Leu Lys Glu Leu Gly Asp Phe Tyr Leu 
            180                 185                 190         


Glu Leu His Trp Asp Phe Gln Ser Trp Val Pro Leu Leu Ser Arg Ile 
        195                 200                 205             


Leu Pro Ser Asp Ala Cys Lys Ile Tyr Lys Gln Gly Ile Asn Ile Arg 
    210                 215                 220                 


Leu Asp Thr Thr Leu Ile Asp Phe Thr Asp Met Lys Cys Gln Arg Gly 
225                 230                 235                 240 


Asp Leu Ser Phe Ile Phe Asn Gly Asp Ala Ala Pro Ser Glu Ser Phe 
                245                 250                 255     


Val Val Leu Asp Asn Glu Gln Lys Val Tyr Gln Arg Ile His His Glu 
            260                 265                 270         


Glu Ser Glu Met Glu Thr Glu Glu Glu Val Asp Ile Leu Met Ser Ser 
        275                 280                 285             


Asp Ile Tyr Ser Ala Thr Leu Ser Thr Lys Ser Ile Ser Phe Thr Arg 
    290                 295                 300                 


Ala Gln Thr Gly Trp Leu Phe Arg Glu Asp Lys Thr Glu Arg Val Gly 
305                 310                 315                 320 


Asn Phe Leu Ala Asp Phe Tyr Leu Val Asn Gly Leu Val Leu Glu Ser 
                325                 330                 335     


Arg Lys Arg Arg Glu His Leu Ser Glu Glu Asp Ile Leu Arg Asn Lys 
            340                 345                 350         


Ala Ile Met Glu Ser Leu Ser Lys Gly Gly Asn Ile Met Glu Gln Asn 
        355                 360                 365             


Phe Glu Pro Ile Arg Arg Gln Ser Leu Thr Pro Pro Pro Gln Asn Thr 
    370                 375                 380                 


Ile Thr Trp Glu Glu Tyr Ile Ser Ala Glu Asn Gly Lys Ala Pro His 
385                 390                 395                 400 


Leu Gly Arg Glu Leu Val Cys Lys Glu Ser Lys Lys Thr Phe Lys Ala 
                405                 410                 415     


Thr Ile Ala Met Ser Gln Glu Phe Pro Leu Gly Ile Glu Leu Leu Leu 
            420                 425                 430         


Asn Val Leu Glu Val Val Ala Pro Phe Lys His Phe Asn Lys Leu Arg 
        435                 440                 445             


Glu Phe Val Gln Met Lys Leu Pro Pro Gly Phe Pro Val Lys Leu Asp 
    450                 455                 460                 


Ile Pro Val Phe Pro Thr Ile Thr Ala Thr Val Thr Phe Gln Glu Phe 
465                 470                 475                 480 


Arg Tyr Asp Glu Phe Asp Gly Ser Ile Phe Thr Ile Pro Asp Asp Tyr 
                485                 490                 495     


Lys Glu Asp Pro Ser Arg Phe Pro Asp Leu 
            500                 505     


<210> 4916
<211> 232
<212> PRT
<213> Homo sapiens

<400> 4916
Met Gln Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser 
1               5                   10                  15      


Pro Leu Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser 
            20                  25                  30          


Pro Ser Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Thr Ser Thr Thr 
        35                  40                  45              


Lys Ser Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly 
    50                  55                  60                  


Ser Ser Gln Gly Thr Ala Cys Ala Gly Thr Gln Pro Gly Ala Gln Pro 
65                  70                  75                  80  


Gly Ala Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp 
                85                  90                  95      


Gln Ser Pro His Thr Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile 
            100                 105                 110         


Pro Pro Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser 
        115                 120                 125             


Ala Gly Gln Pro Ser Pro Val Ser Leu Ser Pro Thr Pro Pro Ser Thr 
    130                 135                 140                 


Pro Ser Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser 
145                 150                 155                 160 


Gly Gln Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val 
                165                 170                 175     


Phe Thr Ser Thr Leu Ser Lys Ser Arg Pro Thr Pro Lys Pro Arg Gln 
            180                 185                 190         


Arg Pro Thr Leu Pro Pro Pro Gln Pro Pro Thr Val Asn Leu Ser Ala 
        195                 200                 205             


Ser Ser Pro Gln Ser Thr Glu Ala Pro Met Leu Asp Gly Met Ser Pro 
    210                 215                 220                 


Gly Glu Ser Met Ser Thr Ala Val 
225                 230         


<210> 4917
<211> 406
<212> PRT
<213> Homo sapiens

<400> 4917
Met His Pro Ala Val Phe Leu Ser Leu Pro Asp Leu Arg Cys Ser Leu 
1               5                   10                  15      


Leu Leu Leu Val Thr Trp Val Phe Thr Pro Val Thr Thr Glu Ile Thr 
            20                  25                  30          


Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile Leu Asn Asn Ala Asp Val 
        35                  40                  45              


Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser Gln Met Leu 
    50                  55                  60                  


His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu Glu Phe Pro 
65                  70                  75                  80  


Asn Glu Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp Gln His Ser 
                85                  90                  95      


Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr Leu Lys Leu 
            100                 105                 110         


Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly Gln Arg Ser 
        115                 120                 125             


Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser Asp Pro Ile 
    130                 135                 140                 


Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr Thr Leu Asp Arg Ser Lys 
145                 150                 155                 160 


Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Asp Asn Tyr Arg 
                165                 170                 175     


Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp Cys Ala Phe Leu 
            180                 185                 190         


Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr Ser Gly Asp Asn 
        195                 200                 205             


Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp Met Val Tyr Leu 
    210                 215                 220                 


Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp Lys 
225                 230                 235                 240 


Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu Leu 
                245                 250                 255     


Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Glu Asp 
            260                 265                 270         


Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu Ile 
        275                 280                 285             


Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys Phe 
    290                 295                 300                 


Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro Val 
305                 310                 315                 320 


Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe Lys 
                325                 330                 335     


Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu His 
            340                 345                 350         


Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr Asp 
        355                 360                 365             


Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser Pro Pro Glu 
    370                 375                 380                 


Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu Leu 
385                 390                 395                 400 


Arg Asp Arg Asp Glu Leu 
                405     


<210> 4918
<211> 1866
<212> PRT
<213> Homo sapiens

<400> 4918
Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu 
65                  70                  75                  80  


Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr 
                85                  90                  95      


Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro 
            100                 105                 110         


Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg 
145                 150                 155                 160 


Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu 
            180                 185                 190         


Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser 
        195                 200                 205             


Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr 
    210                 215                 220                 


Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg 
225                 230                 235                 240 


Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu 
                245                 250                 255     


Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr 
            260                 265                 270         


Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
        275                 280                 285             


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
    290                 295                 300                 


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
                325                 330                 335     


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
            340                 345                 350         


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
        355                 360                 365             


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
    370                 375                 380                 


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
385                 390                 395                 400 


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
                405                 410                 415     


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
            420                 425                 430         


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
        435                 440                 445             


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
    450                 455                 460                 


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
465                 470                 475                 480 


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
                485                 490                 495     


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
            500                 505                 510         


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
        515                 520                 525             


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
    530                 535                 540                 


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
545                 550                 555                 560 


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
                565                 570                 575     


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
            580                 585                 590         


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
        595                 600                 605             


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
    610                 615                 620                 


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
625                 630                 635                 640 


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
                645                 650                 655     


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
            660                 665                 670         


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
        675                 680                 685             


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
    690                 695                 700                 


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
705                 710                 715                 720 


Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys 
                725                 730                 735     


Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn 
            740                 745                 750         


Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His 
        755                 760                 765             


Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val 
    770                 775                 780                 


Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val 
785                 790                 795                 800 


Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro 
                805                 810                 815     


Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu 
            820                 825                 830         


Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg 
        835                 840                 845             


Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala 
    850                 855                 860                 


Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn 
865                 870                 875                 880 


Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln 
                885                 890                 895     


Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val 
            900                 905                 910         


Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu 
        915                 920                 925             


Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe 
    930                 935                 940                 


Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe 
945                 950                 955                 960 


Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser 
                965                 970                 975     


Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu 
            980                 985                 990         


Gln Leu Cys Lys Ala Leu Gly Gly  Ser Cys His Leu Gly  His Leu His 
        995                 1000                 1005             


Leu Asp  Phe Ser Gly Asn Ala  Leu Gly Asp Glu Gly  Ala Ala Arg 
    1010                 1015                 1020             


Leu Ala  Gln Leu Leu Pro Gly  Leu Gly Ala Leu Gln  Ser Leu Asn 
    1025                 1030                 1035             


Leu Ser  Glu Asn Gly Leu Ser  Leu Asp Ala Val Leu  Gly Leu Val 
    1040                 1045                 1050             


Arg Cys  Phe Ser Thr Leu Gln  Trp Leu Phe Arg Leu  Asp Ile Ser 
    1055                 1060                 1065             


Phe Glu  Ser Gln His Ile Leu  Leu Arg Gly Asp Lys  Thr Ser Arg 
    1070                 1075                 1080             


Asp Met  Trp Ala Thr Gly Ser  Leu Pro Asp Phe Pro  Ala Ala Ala 
    1085                 1090                 1095             


Lys Phe  Leu Gly Phe Arg Gln  Arg Cys Ile Pro Arg  Ser Leu Cys 
    1100                 1105                 1110             


Leu Ser  Glu Cys Pro Leu Glu  Pro Pro Ser Leu Thr  Arg Leu Cys 
    1115                 1120                 1125             


Ala Thr  Leu Lys Asp Cys Pro  Gly Pro Leu Glu Leu  Gln Leu Ser 
    1130                 1135                 1140             


Cys Glu  Phe Leu Ser Asp Gln  Ser Leu Glu Thr Leu  Leu Asp Cys 
    1145                 1150                 1155             


Leu Pro  Gln Leu Pro Gln Leu  Ser Leu Leu Gln Leu  Ser Gln Thr 
    1160                 1165                 1170             


Gly Leu  Ser Pro Lys Ser Pro  Phe Leu Leu Ala Asn  Thr Leu Ser 
    1175                 1180                 1185             


Leu Cys  Pro Arg Val Lys Lys  Val Asp Leu Arg Ser  Leu His His 
    1190                 1195                 1200             


Ala Thr  Leu His Phe Arg Ser  Asn Glu Glu Glu Glu  Gly Val Cys 
    1205                 1210                 1215             


Cys Gly  Arg Phe Thr Gly Cys  Ser Leu Ser Gln Glu  His Val Glu 
    1220                 1225                 1230             


Ser Leu  Cys Trp Leu Leu Ser  Lys Cys Lys Asp Leu  Ser Gln Val 
    1235                 1240                 1245             


Asp Leu  Ser Ala Asn Leu Leu  Gly Asp Ser Gly Leu  Arg Cys Leu 
    1250                 1255                 1260             


Leu Glu  Cys Leu Pro Gln Val  Pro Ile Ser Gly Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ser His  Asn Ser Ile Ser Gln  Glu Ser Ala Leu Tyr  Leu Leu Glu 
    1280                 1285                 1290             


Thr Leu  Pro Ser Cys Pro Arg  Val Arg Glu Ala Ser  Val Asn Leu 
    1295                 1300                 1305             


Gly Ser  Glu Gln Ser Phe Arg  Ile His Phe Ser Arg  Glu Asp Gln 
    1310                 1315                 1320             


Ala Gly  Lys Thr Leu Arg Leu  Ser Glu Cys Ser Phe  Arg Pro Glu 
    1325                 1330                 1335             


His Val  Ser Arg Leu Ala Thr  Gly Leu Ser Lys Ser  Leu Gln Leu 
    1340                 1345                 1350             


Thr Glu  Leu Thr Leu Thr Gln  Cys Cys Leu Gly Gln  Lys Gln Leu 
    1355                 1360                 1365             


Ala Ile  Leu Leu Ser Leu Val  Gly Arg Pro Ala Gly  Leu Phe Ser 
    1370                 1375                 1380             


Leu Arg  Val Gln Glu Pro Trp  Ala Asp Arg Ala Arg  Val Leu Ser 
    1385                 1390                 1395             


Leu Leu  Glu Val Cys Ala Gln  Ala Ser Gly Ser Val  Thr Glu Ile 
    1400                 1405                 1410             


Ser Ile  Ser Glu Thr Gln Gln  Gln Leu Cys Val Gln  Leu Glu Phe 
    1415                 1420                 1425             


Pro Arg  Gln Glu Glu Asn Pro  Glu Ala Val Ala Leu  Arg Leu Ala 
    1430                 1435                 1440             


His Cys  Asp Leu Gly Ala His  His Ser Leu Leu Val  Gly Gln Leu 
    1445                 1450                 1455             


Met Glu  Thr Cys Ala Arg Leu  Gln Gln Leu Ser Leu  Ser Gln Val 
    1460                 1465                 1470             


Asn Leu  Cys Glu Asp Asp Asp  Ala Ser Ser Leu Leu  Leu Gln Ser 
    1475                 1480                 1485             


Leu Leu  Leu Ser Leu Ser Glu  Leu Lys Thr Phe Arg  Leu Thr Ser 
    1490                 1495                 1500             


Ser Cys  Val Ser Thr Glu Gly  Leu Ala His Leu Ala  Ser Gly Leu 
    1505                 1510                 1515             


Gly His  Cys His His Leu Glu  Glu Leu Asp Leu Ser  Asn Asn Gln 
    1520                 1525                 1530             


Phe Asp  Glu Glu Gly Thr Lys  Ala Leu Met Arg Ala  Leu Glu Gly 
    1535                 1540                 1545             


Lys Trp  Met Leu Lys Arg Leu  Asp Leu Ser His Leu  Leu Leu Asn 
    1550                 1555                 1560             


Ser Ser  Thr Leu Ala Leu Leu  Thr His Arg Leu Ser  Gln Met Thr 
    1565                 1570                 1575             


Cys Leu  Gln Ser Leu Arg Leu  Asn Arg Asn Ser Ile  Gly Asp Val 
    1580                 1585                 1590             


Gly Cys  Cys His Leu Ser Glu  Ala Leu Arg Ala Ala  Thr Ser Leu 
    1595                 1600                 1605             


Glu Glu  Leu Asp Leu Ser His  Asn Gln Ile Gly Asp  Ala Gly Val 
    1610                 1615                 1620             


Gln His  Leu Ala Thr Ile Leu  Pro Gly Leu Pro Glu  Leu Arg Lys 
    1625                 1630                 1635             


Ile Asp  Leu Ser Gly Asn Ser  Ile Ser Ser Ala Gly  Gly Val Gln 
    1640                 1645                 1650             


Leu Ala  Glu Ser Leu Val Leu  Cys Arg Arg Leu Glu  Glu Leu Met 
    1655                 1660                 1665             


Leu Gly  Cys Asn Ala Leu Gly  Asp Pro Thr Ala Leu  Gly Leu Ala 
    1670                 1675                 1680             


Gln Glu  Leu Pro Gln His Leu  Arg Val Leu His Leu  Pro Phe Ser 
    1685                 1690                 1695             


His Leu  Gly Pro Gly Gly Ala  Leu Ser Leu Ala Gln  Ala Leu Asp 
    1700                 1705                 1710             


Gly Ser  Pro His Leu Glu Glu  Ile Ser Leu Ala Glu  Asn Asn Leu 
    1715                 1720                 1725             


Ala Gly  Gly Val Leu Arg Phe  Cys Met Glu Leu Pro  Leu Leu Arg 
    1730                 1735                 1740             


Gln Ile  Asp Leu Val Ser Cys  Lys Ile Asp Asn Gln  Thr Ala Lys 
    1745                 1750                 1755             


Leu Leu  Thr Ser Ser Phe Thr  Ser Cys Pro Ala Leu  Glu Val Ile 
    1760                 1765                 1770             


Leu Leu  Ser Trp Asn Leu Leu  Gly Asp Glu Ala Ala  Ala Glu Leu 
    1775                 1780                 1785             


Ala Gln  Val Leu Pro Gln Met  Gly Arg Leu Lys Arg  Val Asp Leu 
    1790                 1795                 1800             


Glu Lys  Asn Gln Ile Thr Ala  Leu Gly Ala Trp Leu  Leu Ala Glu 
    1805                 1810                 1815             


Gly Leu  Ala Gln Gly Ser Ser  Ile Gln Val Ile Arg  Leu Trp Asn 
    1820                 1825                 1830             


Asn Pro  Ile Pro Cys Asp Met  Ala Gln His Leu Lys  Ser Gln Glu 
    1835                 1840                 1845             


Pro Arg  Leu Asp Phe Ala Phe  Phe Asp Asn Gln Pro  Gln Ala Pro 
    1850                 1855                 1860             


Trp Gly  Thr 
    1865     


<210> 4919
<211> 298
<212> PRT
<213> Homo sapiens

<400> 4919
Met Met Asn Val Asn Thr Arg Gly Thr Tyr Leu Ala Ser Lys Ala Cys 
1               5                   10                  15      


Ile Pro Tyr Leu Lys Lys Ser Lys Val Ala His Ile Leu Asn Ile Ser 
            20                  25                  30          


Pro Pro Leu Asn Leu Asn Pro Val Trp Phe Lys Gln His Cys Ala Tyr 
        35                  40                  45              


Thr Ile Ala Lys Tyr Gly Met Ser Met Tyr Val Leu Gly Met Ala Glu 
    50                  55                  60                  


Glu Phe Lys Gly Glu Ile Ala Val Asn Ala Leu Trp Pro Lys Thr Ala 
65                  70                  75                  80  


Ile His Thr Ala Ala Met Asp Met Leu Gly Gly Pro Gly Ile Glu Ser 
                85                  90                  95      


Gln Cys Arg Lys Val Asp Ile Ile Ala Asp Ala Ala Tyr Ser Ile Phe 
            100                 105                 110         


Gln Lys Pro Lys Ser Phe Thr Gly Asn Phe Val Ile Asp Glu Asn Ile 
        115                 120                 125             


Leu Lys Glu Glu Gly Ile Glu Asn Phe Asp Val Tyr Ala Ile Lys Pro 
    130                 135                 140                 


Gly His Pro Leu Gln Pro Asp Phe Phe Leu Asp Glu Tyr Pro Glu Ala 
145                 150                 155                 160 


Val Ser Lys Lys Val Glu Ser Thr Gly Ala Val Pro Glu Phe Lys Glu 
                165                 170                 175     


Glu Lys Leu Gln Leu Gln Pro Lys Pro Arg Ser Gly Ala Val Glu Glu 
            180                 185                 190         


Thr Phe Arg Ile Val Lys Asp Ser Leu Ser Asp Asp Val Val Lys Ala 
        195                 200                 205             


Thr Gln Ala Ile Tyr Leu Phe Glu Leu Ser Gly Glu Asp Gly Gly Thr 
    210                 215                 220                 


Trp Phe Leu Asp Leu Lys Ser Lys Gly Gly Asn Val Gly Tyr Gly Glu 
225                 230                 235                 240 


Pro Ser Asp Gln Ala Asp Val Val Met Ser Met Thr Thr Asp Asp Phe 
                245                 250                 255     


Val Lys Met Phe Ser Gly Lys Leu Lys Pro Thr Met Ala Phe Met Ser 
            260                 265                 270         


Gly Lys Leu Lys Ile Lys Gly Asn Met Ala Leu Ala Ile Lys Leu Glu 
        275                 280                 285             


Lys Leu Met Asn Gln Met Asn Ala Arg Leu 
    290                 295             


<210> 4920
<211> 1341
<212> PRT
<213> Homo sapiens

<400> 4920
Met Trp Arg Arg Lys His Pro Arg Thr Ser Gly Gly Thr Arg Gly Val 
1               5                   10                  15      


Leu Ser Gly Asn Arg Gly Val Glu Tyr Gly Ser Gly Arg Gly His Leu 
            20                  25                  30          


Gly Thr Phe Glu Gly Arg Trp Arg Lys Leu Pro Lys Met Pro Glu Ala 
        35                  40                  45              


Val Gly Thr Asp Pro Ser Thr Ser Arg Lys Met Ala Glu Leu Glu Glu 
    50                  55                  60                  


Val Thr Leu Asp Gly Lys Pro Leu Gln Ala Leu Arg Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Ala Leu Glu Gln Arg Gly Leu Ala Lys Ser Gly Gln Lys Ser 
                85                  90                  95      


Ala Leu Val Lys Arg Leu Lys Gly Ala Leu Met Leu Glu Asn Leu Gln 
            100                 105                 110         


Lys His Ser Thr Pro His Ala Ala Phe Gln Pro Asn Ser Gln Ile Gly 
        115                 120                 125             


Glu Glu Met Ser Gln Asn Ser Phe Ile Lys Gln Tyr Leu Glu Lys Gln 
    130                 135                 140                 


Gln Glu Leu Leu Arg Gln Arg Leu Glu Arg Glu Ala Arg Glu Ala Ala 
145                 150                 155                 160 


Glu Leu Glu Glu Ala Ser Ala Glu Ser Glu Asp Glu Met Ile His Pro 
                165                 170                 175     


Glu Gly Val Ala Ser Leu Leu Pro Pro Asp Phe Gln Ser Ser Leu Glu 
            180                 185                 190         


Arg Pro Glu Leu Glu Leu Ser Arg His Ser Pro Arg Lys Ser Ser Ser 
        195                 200                 205             


Ile Ser Glu Glu Lys Gly Asp Ser Asp Asp Glu Lys Pro Arg Lys Gly 
    210                 215                 220                 


Glu Arg Arg Ser Ser Arg Val Arg Gln Ala Arg Ala Ala Lys Leu Ser 
225                 230                 235                 240 


Glu Gly Ser Gln Pro Ala Glu Glu Glu Glu Asp Gln Glu Thr Pro Ser 
                245                 250                 255     


Arg Asn Leu Arg Val Arg Ala Asp Arg Asn Leu Lys Thr Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Gly 
        275                 280                 285             


Asp Asp Glu Gly Gln Lys Ser Arg Glu Ala Pro Ile Leu Lys Glu Phe 
    290                 295                 300                 


Lys Glu Glu Gly Glu Glu Ile Pro Arg Val Lys Pro Glu Glu Met Met 
305                 310                 315                 320 


Asp Glu Arg Pro Lys Thr Arg Ser Gln Glu Gln Glu Val Leu Glu Arg 
                325                 330                 335     


Gly Gly Arg Phe Thr Arg Ser Gln Glu Glu Ala Arg Lys Ser His Leu 
            340                 345                 350         


Ala Arg Gln Gln Gln Glu Lys Glu Met Lys Thr Thr Ser Pro Leu Glu 
        355                 360                 365             


Glu Glu Glu Arg Glu Ile Lys Ser Ser Gln Gly Leu Lys Glu Lys Ser 
    370                 375                 380                 


Lys Ser Pro Ser Pro Pro Arg Leu Thr Glu Asp Arg Lys Lys Ala Ser 
385                 390                 395                 400 


Leu Val Ala Leu Pro Glu Gln Thr Ala Ser Glu Glu Glu Thr Pro Pro 
                405                 410                 415     


Pro Leu Leu Thr Lys Glu Ala Ser Ser Pro Pro Pro His Pro Gln Leu 
            420                 425                 430         


His Ser Glu Glu Glu Ile Glu Pro Met Glu Gly Pro Ala Pro Ala Val 
        435                 440                 445             


Leu Ile Gln Leu Ser Pro Pro Asn Thr Asp Ala Asp Thr Arg Glu Leu 
    450                 455                 460                 


Leu Val Ser Gln His Thr Val Gln Leu Val Gly Gly Leu Ser Pro Leu 
465                 470                 475                 480 


Ser Ser Pro Ser Asp Thr Lys Ala Glu Ser Pro Ala Glu Lys Val Pro 
                485                 490                 495     


Glu Glu Ser Val Leu Pro Leu Val Gln Lys Ser Thr Leu Ala Asp Tyr 
            500                 505                 510         


Ser Ala Gln Lys Asp Leu Glu Pro Glu Ser Asp Arg Ser Ala Gln Pro 
        515                 520                 525             


Leu Pro Leu Lys Ile Glu Glu Leu Ala Leu Ala Lys Gly Ile Thr Glu 
    530                 535                 540                 


Glu Cys Leu Lys Gln Pro Ser Leu Glu Gln Lys Glu Gly Arg Arg Ala 
545                 550                 555                 560 


Ser His Thr Leu Leu Pro Ser His Arg Leu Lys Gln Ser Ala Asp Ser 
                565                 570                 575     


Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Asp Ser Ser Gly Ser Arg Ser His Ser Pro Leu Arg 
        595                 600                 605             


Ser Lys Gln Arg Asp Val Ala Gln Ala Arg Thr His Ala Asn Pro Arg 
    610                 615                 620                 


Gly Arg Pro Lys Met Gly Ser Arg Ser Thr Ser Glu Ser Arg Ser Arg 
625                 630                 635                 640 


Ser Arg Ser Arg Ser Arg Ser Ala Ser Ser Asn Ser Arg Lys Ser Leu 
                645                 650                 655     


Ser Pro Gly Val Ser Arg Asp Ser Ser Thr Ser Tyr Thr Glu Thr Lys 
            660                 665                 670         


Asp Pro Ser Ser Gly Gln Glu Val Ala Thr Pro Pro Val Pro Gln Leu 
        675                 680                 685             


Gln Val Cys Glu Pro Lys Glu Arg Thr Ser Thr Ser Ser Ser Ser Val 
    690                 695                 700                 


Gln Ala Arg Arg Leu Ser Gln Pro Glu Ser Ala Glu Lys His Val Thr 
705                 710                 715                 720 


Gln Arg Leu Gln Pro Glu Arg Gly Ser Pro Lys Lys Cys Glu Ala Glu 
                725                 730                 735     


Glu Ala Glu Pro Pro Ala Ala Thr Gln Pro Gln Thr Ser Glu Thr Gln 
            740                 745                 750         


Thr Ser His Leu Pro Glu Ser Glu Arg Ile His His Thr Val Glu Glu 
        755                 760                 765             


Lys Glu Glu Val Thr Met Asp Thr Ser Glu Asn Arg Pro Glu Asn Asp 
    770                 775                 780                 


Val Pro Glu Pro Pro Met Pro Ile Ala Asp Gln Val Ser Asn Asp Asp 
785                 790                 795                 800 


Arg Pro Glu Gly Ser Val Glu Asp Glu Glu Lys Lys Glu Ser Ser Leu 
                805                 810                 815     


Pro Lys Ser Phe Lys Arg Lys Ile Ser Val Val Ser Ala Thr Lys Gly 
            820                 825                 830         


Val Pro Ala Gly Asn Ser Asp Thr Glu Gly Gly Gln Pro Gly Arg Lys 
        835                 840                 845             


Arg Arg Trp Gly Ala Ser Thr Ala Thr Thr Gln Lys Lys Pro Ser Ile 
    850                 855                 860                 


Ser Ile Thr Thr Glu Ser Leu Lys Ser Leu Ile Pro Asp Ile Lys Pro 
865                 870                 875                 880 


Leu Ala Gly Gln Glu Ala Val Val Asp Leu His Ala Asp Asp Ser Arg 
                885                 890                 895     


Ile Ser Glu Asp Glu Thr Glu Arg Asn Gly Asp Asp Gly Thr His Asp 
            900                 905                 910         


Lys Gly Leu Lys Ile Cys Arg Thr Val Thr Gln Val Val Pro Ala Glu 
        915                 920                 925             


Gly Gln Glu Asn Gly Gln Arg Glu Glu Glu Glu Glu Glu Lys Glu Pro 
    930                 935                 940                 


Glu Ala Glu Pro Pro Val Pro Pro Gln Val Ser Val Glu Val Ala Leu 
945                 950                 955                 960 


Pro Pro Pro Ala Glu His Glu Val Lys Lys Val Thr Leu Gly Asp Thr 
                965                 970                 975     


Leu Thr Arg Arg Ser Ile Ser Gln Gln Lys Ser Gly Val Ser Ile Thr 
            980                 985                 990         


Ile Asp Asp Pro Val Arg Thr Ala  Gln Val Pro Ser Pro  Pro Arg Gly 
        995                 1000                 1005             


Lys Ile  Ser Asn Ile Val His  Ile Ser Asn Leu Val  Arg Pro Phe 
    1010                 1015                 1020             


Thr Leu  Gly Gln Leu Lys Glu  Leu Leu Gly Arg Thr  Gly Thr Leu 
    1025                 1030                 1035             


Val Glu  Glu Ala Phe Trp Ile  Asp Lys Ile Lys Ser  His Cys Phe 
    1040                 1045                 1050             


Val Thr  Tyr Ser Thr Val Glu  Glu Ala Val Ala Thr  Arg Thr Ala 
    1055                 1060                 1065             


Leu His  Gly Val Lys Trp Pro  Gln Ser Asn Pro Lys  Phe Leu Cys 
    1070                 1075                 1080             


Ala Asp  Tyr Ala Glu Gln Asp  Glu Leu Asp Tyr His  Arg Gly Leu 
    1085                 1090                 1095             


Leu Val  Asp Arg Pro Ser Glu  Thr Lys Thr Glu Glu  Gln Gly Ile 
    1100                 1105                 1110             


Pro Arg  Pro Leu His Pro Pro  Pro Pro Pro Pro Val  Gln Pro Pro 
    1115                 1120                 1125             


Gln His  Pro Arg Ala Glu Gln  Arg Glu Gln Glu Arg  Ala Val Arg 
    1130                 1135                 1140             


Glu Gln  Trp Ala Glu Arg Glu  Arg Glu Met Glu Arg  Arg Glu Arg 
    1145                 1150                 1155             


Thr Arg  Ser Glu Arg Glu Trp  Asp Arg Asp Lys Val  Arg Glu Gly 
    1160                 1165                 1170             


Pro Arg  Ser Arg Ser Arg Ser  Arg Asp Arg Arg Arg  Lys Glu Arg 
    1175                 1180                 1185             


Ala Lys  Ser Lys Glu Lys Lys  Ser Glu Lys Lys Glu  Lys Ala Gln 
    1190                 1195                 1200             


Glu Glu  Pro Pro Ala Lys Leu  Leu Asp Asp Leu Phe  Arg Lys Thr 
    1205                 1210                 1215             


Lys Ala  Ala Pro Cys Ile Tyr  Trp Leu Pro Leu Thr  Asp Ser Gln 
    1220                 1225                 1230             


Ile Val  Gln Lys Glu Ala Glu  Arg Ala Glu Arg Ala  Lys Glu Arg 
    1235                 1240                 1245             


Glu Lys  Arg Arg Lys Glu Gln  Glu Glu Glu Glu Gln  Lys Glu Arg 
    1250                 1255                 1260             


Glu Lys  Glu Ala Glu Arg Glu  Arg Asn Arg Gln Leu  Glu Arg Glu 
    1265                 1270                 1275             


Lys Arg  Arg Glu His Ser Arg  Glu Arg Asp Arg Glu  Arg Glu Arg 
    1280                 1285                 1290             


Glu Arg  Glu Arg Asp Arg Gly  Asp Arg Asp Arg Asp  Arg Glu Arg 
    1295                 1300                 1305             


Asp Arg  Glu Arg Gly Arg Glu  Arg Asp Arg Arg Asp  Thr Lys Arg 
    1310                 1315                 1320             


His Ser  Arg Ser Arg Ser Arg  Ser Thr Pro Val Arg  Asp Arg Gly 
    1325                 1330                 1335             


Gly Arg  Arg 
    1340     


<210> 4921
<211> 199
<212> PRT
<213> Homo sapiens

<400> 4921
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210> 4922
<211> 358
<212> PRT
<213> Homo sapiens

<400> 4922
Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
1               5                   10                  15      


Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
            20                  25                  30          


Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
        35                  40                  45              


Asp Tyr Ala Gly Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser 
    50                  55                  60                  


Thr Gln Ala His Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn 
65                  70                  75                  80  


Gly Ser Leu Thr Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser 
                85                  90                  95      


Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg 
            100                 105                 110         


Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg 
        115                 120                 125             


Gln Met Phe Gly Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp 
    130                 135                 140                 


Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg 
145                 150                 155                 160 


Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys 
                165                 170                 175     


Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro Val Val Gly 
            180                 185                 190         


Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe Gln Ala Asp 
        195                 200                 205             


Val Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly Arg Gly Gly 
    210                 215                 220                 


Ile Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro Tyr Pro Thr 
225                 230                 235                 240 


Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu Arg Gly Arg 
                245                 250                 255     


Gly Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro Thr Ala Ile 
            260                 265                 270         


Pro Ala Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr Gly Ala Asp 
        275                 280                 285             


Leu Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln Pro Ala Thr Ala 
    290                 295                 300                 


Thr Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Tyr Ser Asp Gly 
305                 310                 315                 320 


Tyr Gly Arg Val Tyr Thr Ala Asp Pro Tyr His Ala Leu Ala Pro Ala 
                325                 330                 335     


Ala Ser Tyr Gly Val Gly Ala Val Ala Ser Leu Tyr Arg Gly Gly Tyr 
            340                 345                 350         


Ser Arg Phe Ala Pro Tyr 
        355             


<210> 4923
<211> 531
<212> PRT
<213> Homo sapiens

<400> 4923
Met Ser Tyr Pro Ala Asp Asp Tyr Glu Ser Glu Ala Ala Tyr Asp Pro 
1               5                   10                  15      


Tyr Ala Tyr Pro Ser Asp Tyr Asp Met His Thr Gly Asp Pro Lys Gln 
            20                  25                  30          


Asp Leu Ala Tyr Glu Arg Gln Tyr Glu Gln Gln Thr Tyr Gln Val Ile 
        35                  40                  45              


Pro Glu Val Ile Lys Asn Phe Ile Gln Tyr Phe His Lys Thr Val Ser 
    50                  55                  60                  


Asp Leu Ile Asp Gln Lys Val Tyr Glu Leu Gln Ala Ser Arg Val Ser 
65                  70                  75                  80  


Ser Asp Val Ile Asp Gln Lys Val Tyr Glu Ile Gln Asp Ile Tyr Glu 
                85                  90                  95      


Asn Ser Trp Thr Lys Leu Thr Glu Arg Phe Phe Lys Asn Thr Pro Trp 
            100                 105                 110         


Pro Glu Ala Glu Ala Ile Ala Pro Gln Val Gly Asn Asp Ala Val Phe 
        115                 120                 125             


Leu Ile Leu Tyr Lys Ile Leu Gln Ala His Gly Pro Ala Pro Leu Glu 
    130                 135                 140                 


Leu Pro Asn Gln Trp Leu Trp Asp Ile Ile Asp Glu Phe Ile Tyr Gln 
145                 150                 155                 160 


Phe Gln Ser Phe Ser Gln Tyr Arg Cys Lys Thr Ala Lys Lys Ser Glu 
                165                 170                 175     


Glu Glu Ile Asp Phe Leu Arg Ser Asn Pro Lys Ile Trp Asn Val His 
            180                 185                 190         


Ser Val Leu Asn Val Leu His Ser Leu Val Asp Lys Ser Asn Ile Asn 
        195                 200                 205             


Arg Gln Leu Glu Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val Ala 
    210                 215                 220                 


Gly Glu Tyr Gly Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe Ser 
225                 230                 235                 240 


Leu Val Gly Leu Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr Gln 
                245                 250                 255     


Ala Ile Lys Val Leu Glu Asn Ile Glu Leu Asn Lys Lys Ser Met Tyr 
            260                 265                 270         


Ser Arg Val Pro Glu Cys Gln Val Thr Thr Tyr Tyr Tyr Val Gly Phe 
        275                 280                 285             


Ala Tyr Leu Met Met Arg Arg Tyr Gln Asp Ala Ile Arg Val Phe Ala 
    290                 295                 300                 


Asn Ile Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln Arg Thr 
305                 310                 315                 320 


Thr Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met His Ala 
                325                 330                 335     


Leu Leu Ala Ile Ala Leu Thr Met Tyr Pro Met Arg Ile Asp Glu Ser 
            340                 345                 350         


Ile His Leu Gln Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg Met 
        355                 360                 365             


Gln Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr Ser Cys 
    370                 375                 380                 


Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val His Pro 
385                 390                 395                 400 


Asn Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe Ser Asp 
                405                 410                 415     


Glu Val Gln Gln Gln Ala Gln Leu Ser Thr Ile Arg Ser Phe Leu Lys 
            420                 425                 430         


Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp Leu 
        435                 440                 445             


Thr Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His Lys Met 
    450                 455                 460                 


Lys Asn Leu Val Trp Thr Ser Gly Ile Ser Ala Leu Asp Gly Glu Phe 
465                 470                 475                 480 


Gln Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met Ile His 
                485                 490                 495     


Ile Ala Asp Thr Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe Ile Arg 
            500                 505                 510         


Gln Ile His Lys Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met Gly 
        515                 520                 525             


Gln Arg Pro 
    530     


<210> 4924
<211> 1983
<212> PRT
<213> Homo sapiens

<400> 4924
Met Ser Gly Asn Lys Arg Gly Ser Arg Ala Ser Cys Pro His Arg Gly 
1               5                   10                  15      


Ala Glu Cys Leu Leu Pro Trp Ala Ala Leu Asn Leu Gln Gly Phe Gln 
            20                  25                  30          


Leu Leu Leu Leu His Pro Ser Ala Thr Ala Met Met Asp Val Ser Glu 
        35                  40                  45              


Leu Gly Glu Ser Ala Arg Tyr Leu Arg Gln Gly Tyr Gln Glu Met Thr 
    50                  55                  60                  


Lys Val His Thr Ile Pro Trp Asp Gly Lys Lys Arg Val Trp Val Pro 
65                  70                  75                  80  


Asp Glu Gln Asp Ala Tyr Val Glu Ala Glu Val Lys Ser Glu Ala Thr 
                85                  90                  95      


Gly Gly Arg Val Thr Val Glu Thr Lys Asp Gln Lys Val Leu Met Val 
            100                 105                 110         


Arg Glu Ala Glu Leu Gln Pro Met Asn Pro Pro Arg Phe Asp Leu Leu 
        115                 120                 125             


Glu Asp Met Ala Met Met Thr His Leu Asn Glu Ala Ser Val Leu His 
    130                 135                 140                 


Asn Leu Arg Gln Arg Tyr Ala Arg Trp Met Ile Tyr Thr Tyr Ser Gly 
145                 150                 155                 160 


Leu Phe Cys Val Thr Ile Asn Pro Tyr Lys Trp Leu Pro Val Tyr Thr 
                165                 170                 175     


Ala Ser Val Val Ala Ala Tyr Lys Gly Lys Arg Arg Ser Asp Ser Pro 
            180                 185                 190         


Pro His Ile Tyr Ala Val Ala Asp Asn Ala Tyr Asn Asp Met Leu Arg 
        195                 200                 205             


Asn Arg Asp Asn Gln Ser Met Leu Ile Thr Gly Glu Ser Gly Ala Gly 
    210                 215                 220                 


Lys Thr Val Asn Thr Lys Arg Val Ile Gln Tyr Phe Ala Ile Val Ala 
225                 230                 235                 240 


Ala Leu Gly Asp Gly Pro Gly Lys Lys Ala Gln Phe Leu Ala Thr Lys 
                245                 250                 255     


Thr Gly Gly Thr Leu Glu Asp Gln Ile Ile Glu Ala Asn Pro Ala Met 
            260                 265                 270         


Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser Ser Arg 
        275                 280                 285             


Phe Gly Lys Phe Ile Arg Ile His Phe Gly Pro Ser Gly Lys Leu Ala 
    290                 295                 300                 


Ser Ala Asp Ile Asp Ser Tyr Leu Leu Glu Lys Ser Arg Val Ile Phe 
305                 310                 315                 320 


Gln Leu Pro Gly Glu Arg Ser Tyr His Val Tyr Tyr Gln Ile Leu Ser 
                325                 330                 335     


Gly Arg Lys Pro Glu Leu Gln Asp Met Leu Leu Leu Ser Met Asn Pro 
            340                 345                 350         


Tyr Asp Tyr His Phe Cys Ser Gln Gly Val Ile Thr Val Asp Asn Met 
        355                 360                 365             


Asn Asp Gly Glu Glu Leu Ile Ala Thr Asp His Ala Met Asp Ile Leu 
    370                 375                 380                 


Gly Phe Ser Val Asp Glu Lys Cys Ala Cys Tyr Lys Ile Val Gly Ala 
385                 390                 395                 400 


Leu Leu His Phe Gly Asn Met Lys Phe Lys Gln Lys Gln Arg Glu Glu 
                405                 410                 415     


Gln Ala Glu Ala Asp Gly Thr Glu Ser Ala Asp Lys Ala Ala Tyr Leu 
            420                 425                 430         


Met Gly Val Ser Ser Gly Asp Leu Leu Lys Gly Leu Leu His Pro Arg 
        435                 440                 445             


Val Arg Val Gly Asn Glu Tyr Val Thr Lys Gly Gln Ser Val Glu Gln 
    450                 455                 460                 


Val Val Phe Ala Val Gly Ala Leu Ala Lys Ala Thr Tyr Asp Arg Leu 
465                 470                 475                 480 


Phe Arg Trp Leu Val Ser Arg Ile Asn Gln Thr Leu Asp Thr Lys Leu 
                485                 490                 495     


Pro Arg Gln Phe Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Ile 
            500                 505                 510         


Phe Glu Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe Thr Asn Glu 
        515                 520                 525             


Lys Leu Gln Gln Phe Phe Asn Gln His Met Phe Val Leu Glu Gln Glu 
    530                 535                 540                 


Glu Tyr Lys Arg Glu Gly Ile Asp Trp Val Phe Ile Asp Phe Gly Leu 
545                 550                 555                 560 


Asp Leu Gln Pro Cys Ile Asp Leu Ile Glu Lys Pro Leu Gly Ile Leu 
                565                 570                 575     


Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Ser Asp Ala Ser 
            580                 585                 590         


Phe Arg Ala Lys Leu Tyr Asp Asn His Ala Gly Lys Ser Pro Asn Phe 
        595                 600                 605             


Gln Gln Pro Arg Pro Asp Lys Lys Arg Lys Tyr Gln Ala His Phe Glu 
    610                 615                 620                 


Val Val His Tyr Ala Gly Val Val Pro Tyr Ser Ile Val Gly Trp Leu 
625                 630                 635                 640 


Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Pro Ile Phe Gln 
                645                 650                 655     


Lys Ser Gln Asn Arg Leu Leu Ala Thr Leu Tyr Glu Asn Tyr Ala Gly 
            660                 665                 670         


Ser Cys Ser Thr Glu Pro Pro Lys Ser Gly Val Lys Glu Lys Arg Lys 
        675                 680                 685             


Lys Ala Ala Ser Phe Gln Thr Val Ser Gln Leu His Lys Glu Asn Leu 
    690                 695                 700                 


Asn Lys Leu Met Thr Asn Leu Arg Ala Thr Gln Pro His Phe Val Arg 
705                 710                 715                 720 


Cys Ile Val Pro Asn Glu Asn Lys Thr Pro Gly Val Met Asp Ala Phe 
                725                 730                 735     


Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg 
            740                 745                 750         


Ile Cys Arg Gln Gly Phe Pro Asn Arg Leu Leu Tyr Thr Asp Phe Arg 
        755                 760                 765             


Gln Arg Tyr Arg Ile Leu Asn Pro Ser Ala Ile Pro Asp Asp Thr Phe 
    770                 775                 780                 


Met Asp Ser Arg Lys Ala Thr Glu Lys Leu Leu Gly Ser Leu Asp Leu 
785                 790                 795                 800 


Asp His Thr Gln Tyr Gln Phe Gly His Thr Lys Val Phe Phe Lys Ala 
                805                 810                 815     


Gly Leu Leu Gly Val Leu Glu Glu Leu Arg Asp Gln Arg Leu Ala Lys 
            820                 825                 830         


Val Leu Thr Leu Leu Gln Ala Arg Ser Arg Gly Arg Leu Met Arg Leu 
        835                 840                 845             


Glu Tyr Gln Arg Leu Leu Gly Gly Arg Asp Ala Leu Phe Thr Ile Gln 
    850                 855                 860                 


Trp Asn Ile Arg Ala Phe Asn Ala Val Lys Asn Trp Ser Trp Met Lys 
865                 870                 875                 880 


Leu Phe Phe Lys Met Lys Pro Leu Leu Arg Ser Ala Gln Ala Glu Glu 
                885                 890                 895     


Glu Leu Ala Ala Leu Arg Ala Glu Leu Arg Gly Leu Arg Gly Ala Leu 
            900                 905                 910         


Ala Ala Ala Glu Ala Lys Arg Gln Glu Leu Glu Glu Thr His Val Ser 
        915                 920                 925             


Ile Thr Gln Glu Lys Asn Asp Leu Ala Leu Gln Leu Gln Ala Glu Gln 
    930                 935                 940                 


Asp Asn Leu Ala Asp Ala Glu Glu Arg Cys His Leu Leu Ile Lys Ser 
945                 950                 955                 960 


Lys Val Gln Leu Glu Gly Lys Val Lys Glu Leu Ser Glu Arg Leu Glu 
                965                 970                 975     


Asp Glu Glu Glu Val Asn Ala Asp Leu Ala Ala Arg Arg Arg Lys Leu 
            980                 985                 990         


Glu Asp Glu Cys Thr Glu Leu Lys  Lys Asp Ile Asp Asp  Leu Lys Leu 
        995                 1000                 1005             


Thr Leu  Ala Lys Ala Glu Lys  Glu Lys Gln Ala Thr  Glu Asn Lys 
    1010                 1015                 1020             


Val Lys  Asn Leu Thr Glu Glu  Met Ala Ala Leu Asp  Glu Ser Val 
    1025                 1030                 1035             


Ala Arg  Leu Thr Lys Glu Lys  Lys Ala Leu Gln Glu  Ala His Gln 
    1040                 1045                 1050             


Gln Ala  Leu Gly Asp Leu Gln  Ala Glu Glu Asp Arg  Val Ser Ala 
    1055                 1060                 1065             


Leu Thr  Lys Ala Lys Leu Arg  Leu Glu Gln Gln Val  Glu Asp Leu 
    1070                 1075                 1080             


Glu Cys  Ser Leu Glu Gln Glu  Lys Lys Leu Arg Met  Asp Thr Glu 
    1085                 1090                 1095             


Arg Ala  Lys Arg Lys Leu Glu  Gly Asp Leu Lys Leu  Thr Gln Glu 
    1100                 1105                 1110             


Ser Val  Ala Asp Ala Ala Gln  Asp Lys Gln Gln Leu  Glu Glu Lys 
    1115                 1120                 1125             


Leu Lys  Lys Lys Asp Ser Glu  Leu Ser Gln Leu Ser  Leu Arg Val 
    1130                 1135                 1140             


Glu Asp  Glu Gln Leu Leu Gly  Ala Gln Met Gln Lys  Lys Ile Lys 
    1145                 1150                 1155             


Glu Leu  Gln Ala Arg Ala Glu  Glu Leu Glu Glu Glu  Leu Glu Ala 
    1160                 1165                 1170             


Glu Arg  Ala Ala Arg Ala Arg  Val Glu Lys Gln Arg  Ala Glu Ala 
    1175                 1180                 1185             


Ala Arg  Glu Leu Glu Glu Leu  Ser Glu Arg Leu Glu  Glu Ala Gly 
    1190                 1195                 1200             


Gly Ala  Ser Ala Gly Gln Arg  Glu Gly Cys Arg Lys  Arg Glu Ala 
    1205                 1210                 1215             


Glu Leu  Gly Arg Leu Arg Arg  Glu Leu Glu Glu Ala  Ala Leu Arg 
    1220                 1225                 1230             


His Glu  Ala Thr Val Ala Ala  Leu Arg Arg Lys Gln  Ala Glu Gly 
    1235                 1240                 1245             


Ala Ala  Glu Leu Gly Glu Gln  Val Asp Ser Leu Gln  Arg Val Arg 
    1250                 1255                 1260             


Gln Lys  Leu Glu Lys Glu Lys  Ser Glu Leu Arg Met  Glu Val Asp 
    1265                 1270                 1275             


Asp Leu  Ala Ala Asn Val Glu  Thr Leu Thr Arg Ala  Lys Ala Ser 
    1280                 1285                 1290             


Ala Glu  Lys Leu Cys Arg Thr  Tyr Glu Asp Gln Leu  Ser Glu Ala 
    1295                 1300                 1305             


Lys Ile  Lys Val Glu Glu Leu  Gln Arg Gln Leu Ala  Asp Ala Ser 
    1310                 1315                 1320             


Thr Gln  Arg Gly Arg Leu Gln  Thr Glu Ser Gly Glu  Leu Ser Arg 
    1325                 1330                 1335             


Leu Leu  Glu Glu Lys Glu Cys  Leu Ile Ser Gln Leu  Ser Arg Gly 
    1340                 1345                 1350             


Lys Ala  Leu Ala Ala Gln Ser  Leu Glu Glu Leu Arg  Arg Gln Leu 
    1355                 1360                 1365             


Glu Glu  Glu Ser Lys Ala Lys  Ser Ala Leu Ala His  Ala Val Gln 
    1370                 1375                 1380             


Ala Leu  Arg His Asp Cys Asp  Leu Leu Arg Glu Gln  His Glu Glu 
    1385                 1390                 1395             


Glu Ala  Glu Ala Gln Ala Glu  Leu Gln Arg Leu Leu  Ser Lys Ala 
    1400                 1405                 1410             


Asn Ala  Glu Val Ala Gln Trp  Arg Ser Lys Tyr Glu  Ala Asp Ala 
    1415                 1420                 1425             


Ile Gln  Arg Thr Glu Glu Leu  Glu Glu Ala Lys Lys  Lys Leu Ala 
    1430                 1435                 1440             


Leu Arg  Leu Gln Glu Ala Glu  Glu Gly Val Glu Ala  Ala Asn Ala 
    1445                 1450                 1455             


Lys Cys  Ser Ser Leu Glu Lys  Ala Lys Leu Arg Leu  Gln Thr Glu 
    1460                 1465                 1470             


Ser Glu  Asp Val Thr Leu Glu  Leu Glu Arg Ala Thr  Ser Ala Ala 
    1475                 1480                 1485             


Ala Ala  Leu Asp Lys Lys Gln  Arg His Leu Glu Arg  Ala Leu Glu 
    1490                 1495                 1500             


Glu Arg  Arg Arg Gln Glu Glu  Glu Met Gln Arg Glu  Leu Glu Ala 
    1505                 1510                 1515             


Ala Gln  Arg Glu Ser Arg Gly  Leu Gly Thr Glu Leu  Phe Arg Leu 
    1520                 1525                 1530             


Arg His  Gly His Glu Glu Ala  Leu Glu Ala Leu Glu  Thr Leu Lys 
    1535                 1540                 1545             


Arg Glu  Asn Lys Asn Leu Gln  Glu Glu Ile Ser Asp  Leu Thr Asp 
    1550                 1555                 1560             


Gln Val  Ser Leu Ser Gly Lys  Ser Ile Gln Glu Leu  Glu Lys Thr 
    1565                 1570                 1575             


Lys Lys  Ala Leu Glu Gly Glu  Lys Ser Glu Ile Gln  Ala Ala Leu 
    1580                 1585                 1590             


Glu Glu  Ala Glu Gly Ala Leu  Glu Leu Glu Glu Thr  Lys Thr Leu 
    1595                 1600                 1605             


Arg Ile  Gln Leu Glu Leu Ser  Gln Val Lys Ala Glu  Val Asp Arg 
    1610                 1615                 1620             


Lys Leu  Ala Glu Lys Asp Glu  Glu Cys Ala Asn Leu  Arg Arg Asn 
    1625                 1630                 1635             


His Gln  Arg Ala Val Glu Ser  Leu Gln Ala Ser Leu  Asp Ala Glu 
    1640                 1645                 1650             


Thr Arg  Ala Arg Asn Glu Ala  Leu Arg Leu Lys Lys  Lys Met Glu 
    1655                 1660                 1665             


Gly Asp  Leu Asn Asp Leu Glu  Leu Gln Leu Gly His  Ala Thr Arg 
    1670                 1675                 1680             


Gln Ala  Thr Glu Ala Gln Ala  Ala Thr Arg Leu Met  Gln Ala Gln 
    1685                 1690                 1695             


Leu Lys  Glu Glu Gln Ala Gly  Arg Asp Glu Glu Gln  Arg Leu Ala 
    1700                 1705                 1710             


Ala Glu  Leu His Glu Gln Ala  Gln Ala Leu Glu Arg  Arg Ala Ser 
    1715                 1720                 1725             


Leu Leu  Ala Ala Glu Leu Glu  Glu Leu Arg Ala Ala  Leu Glu Gln 
    1730                 1735                 1740             


Gly Glu  Arg Ser Arg Arg Leu  Ala Glu Gln Glu Leu  Leu Glu Ala 
    1745                 1750                 1755             


Thr Glu  Arg Leu Asn Leu Leu  His Ser Gln Asn Thr  Gly Leu Leu 
    1760                 1765                 1770             


Asn Gln  Lys Lys Lys Leu Glu  Ala Asp Leu Ala Gln  Leu Ser Gly 
    1775                 1780                 1785             


Glu Val  Glu Glu Ala Ala Gln  Glu Arg Arg Glu Ala  Glu Glu Lys 
    1790                 1795                 1800             


Ala Lys  Lys Ala Ile Thr Asp  Ala Ala Met Met Ala  Glu Glu Leu 
    1805                 1810                 1815             


Lys Lys  Glu Gln Asp Thr Ser  Ala His Leu Glu Arg  Met Lys Lys 
    1820                 1825                 1830             


Thr Leu  Glu Gln Thr Val Arg  Glu Leu Gln Ala Arg  Leu Glu Glu 
    1835                 1840                 1845             


Ala Glu  Gln Ala Ala Leu Arg  Gly Gly Lys Lys Gln  Val Gln Lys 
    1850                 1855                 1860             


Leu Glu  Ala Lys Val Arg Glu  Leu Glu Ala Glu Leu  Asp Ala Glu 
    1865                 1870                 1875             


Gln Lys  Lys His Ala Glu Ala  Leu Lys Gly Val Arg  Lys His Glu 
    1880                 1885                 1890             


Arg Arg  Val Lys Glu Leu Ala  Tyr Gln Ala Glu Glu  Asp Arg Lys 
    1895                 1900                 1905             


Asn Leu  Ala Arg Met Gln Asp  Leu Val Asp Lys Leu  Gln Ser Lys 
    1910                 1915                 1920             


Val Lys  Ser Tyr Lys Arg Gln  Phe Glu Glu Ala Glu  Gln Gln Ala 
    1925                 1930                 1935             


Asn Thr  Asn Leu Ala Lys Tyr  Arg Lys Ala Gln His  Glu Leu Asp 
    1940                 1945                 1950             


Asp Ala  Glu Glu Arg Ala Asp  Met Ala Glu Thr Gln  Ala Asn Lys 
    1955                 1960                 1965             


Leu Arg  Ala Arg Thr Arg Asp  Ala Leu Gly Pro Lys  His Lys Glu 
    1970                 1975                 1980             


<210> 4925
<211> 909
<212> PRT
<213> Homo sapiens

<400> 4925
Met Glu Arg Ala Met Glu Gln Leu Asn Arg Leu Thr Arg Ser Leu Arg 
1               5                   10                  15      


Arg Ala Arg Thr Val Glu Leu Pro Glu Asp Asn Glu Thr Ala Val Tyr 
            20                  25                  30          


Thr Leu Met Pro Met Val Met Ala Asp Gln His Arg Ser Val Ser Glu 
        35                  40                  45              


Leu Leu Ser Asn Ser Lys Phe Asp Val Asn Tyr Ala Phe Gly Arg Val 
    50                  55                  60                  


Lys Arg Ser Leu Leu His Ile Ala Ala Asn Cys Gly Ser Val Glu Cys 
65                  70                  75                  80  


Leu Val Leu Leu Leu Lys Lys Gly Ala Asn Pro Asn Tyr Gln Asp Ile 
                85                  90                  95      


Ser Gly Cys Thr Pro Leu His Leu Ala Ala Arg Asn Gly Gln Lys Lys 
            100                 105                 110         


Cys Met Ser Lys Leu Leu Glu Tyr Ser Ala Asp Val Asn Ile Cys Asn 
        115                 120                 125             


Asn Glu Gly Leu Thr Ala Ile His Trp Leu Ala Val Asn Gly Arg Thr 
    130                 135                 140                 


Glu Leu Leu His Asp Leu Val Gln His Val Ser Asp Val Asp Val Glu 
145                 150                 155                 160 


Asp Ala Met Gly Gln Thr Ala Leu His Val Ala Cys Gln Asn Gly His 
                165                 170                 175     


Lys Thr Thr Val Gln Cys Leu Leu Asp Ser Gly Ala Asp Ile Asn Arg 
            180                 185                 190         


Pro Asn Val Ser Gly Ala Thr Pro Leu Tyr Phe Ala Cys Ser His Gly 
        195                 200                 205             


Gln Arg Asp Thr Ala Gln Ile Leu Leu Leu Arg Gly Ala Lys Tyr Leu 
    210                 215                 220                 


Pro Asp Lys Asn Gly Val Thr Pro Leu Asp Leu Cys Val Gln Gly Gly 
225                 230                 235                 240 


Tyr Gly Glu Thr Cys Glu Val Leu Ile Gln Tyr His Pro Arg Leu Phe 
                245                 250                 255     


Gln Thr Ile Ile Gln Met Thr Gln Asn Glu Asp Leu Arg Glu Asn Met 
            260                 265                 270         


Leu Arg Gln Val Leu Glu His Leu Ser Gln Gln Ser Glu Ser Gln Tyr 
        275                 280                 285             


Leu Lys Ile Leu Thr Ser Leu Ala Glu Val Ala Thr Thr Asn Gly His 
    290                 295                 300                 


Lys Leu Leu Ser Leu Ser Ser Asn Tyr Asp Ala Gln Met Lys Ser Leu 
305                 310                 315                 320 


Leu Arg Ile Val Arg Met Phe Cys His Val Phe Arg Ile Gly Pro Ser 
                325                 330                 335     


Ser Pro Ser Asn Gly Ile Asp Met Gly Tyr Asn Gly Asn Lys Thr Pro 
            340                 345                 350         


Arg Ser Gln Val Phe Lys Pro Leu Glu Leu Leu Trp His Ser Leu Asp 
        355                 360                 365             


Glu Trp Leu Val Leu Ile Ala Thr Glu Leu Met Lys Asn Lys Arg Asp 
    370                 375                 380                 


Ser Thr Glu Ile Thr Ser Ile Leu Leu Lys Gln Lys Gly Gln Asp Gln 
385                 390                 395                 400 


Asp Ala Ala Ser Ile Pro Pro Phe Glu Pro Pro Gly Pro Gly Ser Tyr 
                405                 410                 415     


Glu Asn Leu Ser Thr Gly Thr Arg Glu Ser Lys Pro Asp Ala Leu Ala 
            420                 425                 430         


Gly Arg Gln Glu Ala Ser Ala Asp Cys Gln Asp Val Ile Ser Met Thr 
        435                 440                 445             


Ala Asn Arg Leu Ser Ala Val Ile Gln Ala Phe Tyr Met Cys Cys Ser 
    450                 455                 460                 


Cys Gln Met Pro Pro Gly Met Thr Ser Pro Arg Phe Ile Glu Phe Val 
465                 470                 475                 480 


Cys Lys His Asp Glu Val Leu Lys Cys Phe Val Asn Arg Asn Pro Lys 
                485                 490                 495     


Ile Ile Phe Asp His Phe His Phe Leu Leu Glu Cys Pro Glu Leu Met 
            500                 505                 510         


Ser Arg Phe Met His Ile Ile Lys Ala Gln Pro Phe Lys Asp Arg Cys 
        515                 520                 525             


Glu Trp Phe Tyr Glu His Leu His Ser Gly Gln Pro Asp Ser Asp Met 
    530                 535                 540                 


Val His Arg Pro Val Asn Glu Asn Asp Ile Leu Leu Val His Arg Asp 
545                 550                 555                 560 


Ser Ile Phe Arg Ser Ser Cys Glu Val Val Ser Lys Ala Asn Cys Ala 
                565                 570                 575     


Lys Leu Lys Gln Gly Ile Ala Val Arg Phe His Gly Glu Glu Gly Met 
            580                 585                 590         


Gly Gln Gly Val Val Arg Glu Trp Phe Asp Ile Leu Ser Asn Glu Ile 
        595                 600                 605             


Val Asn Pro Asp Tyr Ala Leu Phe Thr Gln Ser Ala Asp Gly Thr Thr 
    610                 615                 620                 


Phe Gln Pro Asn Ser Asn Ser Tyr Val Asn Pro Asp His Leu Asn Tyr 
625                 630                 635                 640 


Phe Arg Phe Ala Gly Gln Ile Leu Gly Leu Ala Leu Asn His Arg Gln 
                645                 650                 655     


Leu Val Asn Ile Tyr Phe Thr Arg Ser Phe Tyr Lys His Ile Leu Gly 
            660                 665                 670         


Ile Pro Val Asn Tyr Gln Asp Val Ala Ser Ile Asp Pro Glu Tyr Ala 
        675                 680                 685             


Lys Asn Leu Gln Trp Ile Leu Asp Asn Asp Ile Ser Asp Leu Gly Leu 
    690                 695                 700                 


Glu Leu Thr Phe Ser Val Glu Thr Asp Val Phe Gly Ala Met Glu Glu 
705                 710                 715                 720 


Val Pro Leu Lys Pro Gly Gly Gly Ser Ile Leu Val Thr Gln Asn Asn 
                725                 730                 735     


Lys Ala Glu Tyr Val Gln Leu Val Thr Glu Leu Arg Met Thr Arg Ala 
            740                 745                 750         


Ile Gln Pro Gln Ile Asn Ala Phe Leu Gln Gly Phe His Met Phe Ile 
        755                 760                 765             


Pro Pro Ser Leu Ile Gln Leu Phe Asp Glu Tyr Glu Leu Glu Leu Leu 
    770                 775                 780                 


Leu Ser Gly Met Pro Glu Ile Asp Val Ser Asp Trp Ile Lys Asn Thr 
785                 790                 795                 800 


Glu Tyr Thr Ser Gly Tyr Glu Arg Glu Asp Pro Val Ile Gln Trp Phe 
                805                 810                 815     


Trp Glu Val Val Glu Asp Ile Thr Gln Glu Glu Arg Val Leu Leu Leu 
            820                 825                 830         


Gln Phe Val Thr Gly Ser Ser Arg Val Pro His Gly Gly Phe Ala Asn 
        835                 840                 845             


Ile Met Gly Gly Ser Gly Leu Gln Asn Phe Thr Ile Ala Ala Val Pro 
    850                 855                 860                 


Tyr Thr Pro Asn Leu Leu Pro Thr Ser Ser Thr Cys Ile Asn Met Leu 
865                 870                 875                 880 


Lys Leu Pro Glu Tyr Pro Ser Lys Glu Ile Leu Lys Asp Arg Leu Leu 
                885                 890                 895     


Val Ala Leu His Cys Gly Ser Tyr Gly Tyr Thr Met Ala 
            900                 905                 


<210> 4926
<211> 892
<212> PRT
<213> Homo sapiens

<400> 4926
Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser 
1               5                   10                  15      


Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr 
            20                  25                  30          


Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp 
        35                  40                  45              


Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg 
    50                  55                  60                  


Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys 
65                  70                  75                  80  


Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro 
                85                  90                  95      


His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu 
            100                 105                 110         


Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala 
        115                 120                 125             


Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr 
    130                 135                 140                 


Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg 
145                 150                 155                 160 


Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu 
                165                 170                 175     


Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg 
            180                 185                 190         


Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu 
        195                 200                 205             


Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro 
    210                 215                 220                 


Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val 
225                 230                 235                 240 


Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln 
                245                 250                 255     


Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr 
            260                 265                 270         


Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys 
        275                 280                 285             


Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile 
    290                 295                 300                 


Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro 
305                 310                 315                 320 


Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg 
                325                 330                 335     


Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln 
            340                 345                 350         


Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val 
        355                 360                 365             


Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala 
    370                 375                 380                 


Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg 
385                 390                 395                 400 


Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile 
                405                 410                 415     


Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val 
            420                 425                 430         


Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val 
        435                 440                 445             


Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly 
    450                 455                 460                 


Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe 
465                 470                 475                 480 


Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp 
                485                 490                 495     


Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile 
            500                 505                 510         


Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg 
        515                 520                 525             


His Gly Ser Lys Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe 
    530                 535                 540                 


Gln Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser 
545                 550                 555                 560 


Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser 
                565                 570                 575     


His Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr 
            580                 585                 590         


Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly 
        595                 600                 605             


Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met 
    610                 615                 620                 


Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe 
625                 630                 635                 640 


His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys 
                645                 650                 655     


Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val 
            660                 665                 670         


Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile 
        675                 680                 685             


Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val 
    690                 695                 700                 


Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly 
705                 710                 715                 720 


Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu 
                725                 730                 735     


Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg 
            740                 745                 750         


Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly 
        755                 760                 765             


Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro 
    770                 775                 780                 


Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met 
785                 790                 795                 800 


Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala 
                805                 810                 815     


Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu 
            820                 825                 830         


His Gly Phe Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu 
        835                 840                 845             


Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr 
    850                 855                 860                 


Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr 
865                 870                 875                 880 


Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr Leu 
                885                 890         


<210> 4927
<211> 510
<212> PRT
<213> Homo sapiens

<400> 4927
Met Ala Ala Glu Leu Val Glu Ala Lys Asn Met Val Met Ser Phe Arg 
1               5                   10                  15      


Val Ser Asp Leu Gln Met Leu Leu Gly Phe Val Gly Arg Ser Lys Ser 
            20                  25                  30          


Gly Leu Lys His Glu Leu Val Thr Arg Ala Leu Gln Leu Val Gln Phe 
        35                  40                  45              


Asp Cys Ser Pro Glu Leu Phe Lys Lys Ile Lys Glu Leu Tyr Glu Thr 
    50                  55                  60                  


Arg Tyr Ala Lys Lys Asn Ser Glu Pro Ala Pro Gln Pro His Arg Pro 
65                  70                  75                  80  


Leu Asp Pro Leu Thr Met His Ser Thr Tyr Asp Arg Ala Gly Ala Val 
                85                  90                  95      


Pro Arg Thr Pro Leu Ala Gly Pro Asn Ile Asp Tyr Pro Val Leu Tyr 
            100                 105                 110         


Gly Lys Tyr Leu Asn Gly Leu Gly Arg Leu Pro Ala Lys Thr Leu Lys 
        115                 120                 125             


Pro Glu Val Arg Leu Val Lys Leu Pro Phe Phe Asn Met Leu Asp Glu 
    130                 135                 140                 


Leu Leu Lys Pro Thr Glu Leu Val Pro Gln Asn Asn Glu Lys Leu Gln 
145                 150                 155                 160 


Glu Ser Pro Cys Ile Phe Ala Leu Thr Pro Arg Gln Val Glu Leu Ile 
                165                 170                 175     


Arg Asn Ser Arg Glu Leu Gln Pro Gly Val Lys Ala Val Gln Val Val 
            180                 185                 190         


Leu Arg Ile Cys Tyr Ser Asp Thr Ser Cys Pro Gln Glu Asp Gln Tyr 
        195                 200                 205             


Pro Pro Asn Ile Ala Val Lys Val Asn His Ser Tyr Cys Ser Val Pro 
    210                 215                 220                 


Gly Tyr Tyr Pro Ser Asn Lys Pro Gly Val Glu Pro Lys Arg Pro Cys 
225                 230                 235                 240 


Arg Pro Ile Asn Leu Thr His Leu Met Tyr Leu Ser Ser Ala Thr Asn 
                245                 250                 255     


Arg Ile Thr Val Thr Trp Gly Asn Tyr Gly Lys Ser Tyr Ser Val Ala 
            260                 265                 270         


Leu Tyr Leu Val Arg Gln Leu Thr Ser Ser Glu Leu Leu Gln Arg Leu 
        275                 280                 285             


Lys Thr Ile Gly Val Lys His Pro Glu Leu Cys Lys Ala Leu Val Lys 
    290                 295                 300                 


Glu Lys Leu Arg Leu Asp Pro Asp Ser Glu Ile Ala Thr Thr Gly Val 
305                 310                 315                 320 


Arg Val Ser Leu Ile Cys Pro Leu Val Lys Met Arg Leu Ser Val Pro 
                325                 330                 335     


Cys Arg Ala Glu Thr Cys Ala His Leu Gln Cys Phe Asp Ala Val Phe 
            340                 345                 350         


Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Met Cys Pro Val Cys 
        355                 360                 365             


Asp Lys Pro Ala Pro Tyr Asp Gln Leu Ile Ile Asp Gly Leu Leu Ser 
    370                 375                 380                 


Lys Ile Leu Ser Glu Cys Glu Asp Ala Asp Glu Ile Glu Tyr Leu Val 
385                 390                 395                 400 


Asp Gly Ser Trp Cys Pro Ile Arg Ala Glu Lys Glu Arg Ser Cys Ser 
                405                 410                 415     


Pro Gln Gly Ala Ile Leu Val Leu Gly Pro Ser Asp Ala Asn Gly Leu 
            420                 425                 430         


Leu Pro Ala Pro Ser Val Asn Gly Ser Gly Ala Leu Gly Ser Thr Gly 
        435                 440                 445             


Gly Gly Gly Pro Val Gly Ser Met Glu Asn Gly Lys Pro Gly Ala Asp 
    450                 455                 460                 


Val Val Asp Leu Thr Leu Asp Ser Ser Ser Ser Ser Glu Asp Glu Glu 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Gly Pro Arg Pro 
                485                 490                 495     


Lys Arg Arg Cys Pro Phe Gln Lys Gly Leu Val Pro Ala Cys 
            500                 505                 510 


<210> 4928
<211> 227
<212> PRT
<213> Homo sapiens

<400> 4928
Met Ala Ala Gln Arg Pro Leu Arg Val Leu Cys Leu Ala Gly Phe Arg 
1               5                   10                  15      


Gln Ser Glu Arg Gly Phe Arg Glu Lys Thr Gly Ala Leu Arg Lys Ala 
            20                  25                  30          


Leu Arg Gly Arg Ala Glu Leu Val Cys Leu Ser Gly Pro His Pro Val 
        35                  40                  45              


Pro Asp Pro Pro Gly Pro Glu Gly Ala Arg Ser Asp Phe Gly Ser Cys 
    50                  55                  60                  


Pro Pro Glu Glu Gln Pro Arg Gly Trp Trp Phe Ser Glu Gln Glu Ala 
65                  70                  75                  80  


Asp Val Phe Ser Ala Leu Glu Glu Pro Ala Val Cys Arg Gly Leu Glu 
                85                  90                  95      


Glu Ser Leu Gly Met Val Ala Gln Ala Leu Asn Arg Leu Gly Pro Phe 
            100                 105                 110         


Asp Gly Leu Leu Gly Phe Ser Gln Gly Ala Ala Leu Ala Ala Leu Val 
        115                 120                 125             


Cys Ala Leu Gly Gln Ala Gly Asp Pro Arg Phe Pro Leu Pro Arg Phe 
    130                 135                 140                 


Ile Leu Leu Val Ser Gly Phe Cys Pro Arg Gly Ile Gly Phe Lys Glu 
145                 150                 155                 160 


Ser Ile Leu Gln Arg Pro Leu Ser Leu Pro Ser Leu His Val Phe Gly 
                165                 170                 175     


Asp Thr Asp Lys Val Ile Pro Ser Gln Glu Ser Val Gln Leu Ala Ser 
            180                 185                 190         


Gln Phe Pro Gly Ala Ile Thr Leu Thr His Ser Gly Gly His Phe Ile 
        195                 200                 205             


Pro Ala Ala Ala Pro Gln Arg Gln Ala Tyr Leu Lys Phe Leu Asp Gln 
    210                 215                 220                 


Phe Ala Glu 
225         


<210> 4929
<211> 551
<212> PRT
<213> Homo sapiens

<400> 4929
Met Glu Glu Ala Glu Leu Val Lys Gly Arg Leu Gln Ala Ile Thr Asp 
1               5                   10                  15      


Lys Arg Lys Ile Gln Glu Glu Ile Ser Gln Lys Arg Leu Lys Ile Glu 
            20                  25                  30          


Glu Asp Lys Leu Lys His Gln His Leu Lys Lys Lys Ala Leu Arg Glu 
        35                  40                  45              


Lys Trp Leu Leu Asp Gly Ile Ser Ser Gly Lys Glu Gln Glu Glu Met 
    50                  55                  60                  


Lys Lys Gln Asn Gln Gln Asp Gln His Gln Ile Gln Val Leu Glu Gln 
65                  70                  75                  80  


Ser Ile Leu Arg Leu Glu Lys Glu Ile Gln Asp Leu Glu Lys Ala Glu 
                85                  90                  95      


Leu Gln Ile Ser Thr Lys Glu Glu Ala Ile Leu Lys Lys Leu Lys Ser 
            100                 105                 110         


Ile Glu Arg Thr Thr Glu Asp Ile Ile Arg Ser Val Lys Val Glu Arg 
        115                 120                 125             


Glu Glu Arg Ala Glu Glu Ser Ile Glu Asp Ile Tyr Ala Asn Ile Pro 
    130                 135                 140                 


Asp Leu Pro Lys Ser Tyr Ile Pro Ser Arg Leu Arg Lys Glu Ile Asn 
145                 150                 155                 160 


Glu Glu Lys Glu Asp Asp Glu Gln Asn Arg Lys Ala Leu Tyr Ala Met 
                165                 170                 175     


Glu Ile Lys Val Glu Lys Asp Leu Lys Thr Gly Glu Ser Thr Val Leu 
            180                 185                 190         


Ser Ser Ile Pro Leu Pro Ser Asp Asp Phe Lys Gly Thr Gly Ile Lys 
        195                 200                 205             


Val Tyr Asp Asp Gly Gln Lys Ser Val Tyr Ala Val Ser Ser Asn His 
    210                 215                 220                 


Ser Ala Ala Tyr Asn Gly Thr Asp Gly Leu Ala Pro Val Glu Val Glu 
225                 230                 235                 240 


Glu Leu Leu Arg Gln Ala Ser Glu Arg Asn Ser Lys Ser Pro Thr Glu 
                245                 250                 255     


Tyr His Glu Pro Val Tyr Ala Asn Pro Phe Tyr Arg Pro Thr Thr Pro 
            260                 265                 270         


Gln Arg Glu Thr Val Thr Pro Gly Pro Asn Phe Gln Glu Arg Ile Lys 
        275                 280                 285             


Ile Lys Thr Asn Gly Leu Gly Ile Gly Val Asn Glu Ser Ile His Asn 
    290                 295                 300                 


Met Gly Asn Gly Leu Ser Glu Glu Arg Gly Asn Asn Phe Asn His Ile 
305                 310                 315                 320 


Ser Pro Ile Pro Pro Val Pro His Pro Arg Ser Val Ile Gln Gln Ala 
                325                 330                 335     


Glu Glu Lys Leu His Thr Pro Gln Lys Arg Leu Met Thr Pro Trp Glu 
            340                 345                 350         


Glu Ser Asn Val Met Gln Asp Lys Asp Ala Pro Ser Pro Lys Pro Arg 
        355                 360                 365             


Leu Ser Pro Arg Glu Thr Ile Phe Gly Lys Ser Glu His Gln Asn Ser 
    370                 375                 380                 


Ser Pro Thr Cys Gln Glu Asp Glu Glu Asp Val Arg Tyr Asn Ile Val 
385                 390                 395                 400 


His Ser Leu Pro Pro Asp Ile Asn Asp Thr Glu Pro Val Thr Met Ile 
                405                 410                 415     


Phe Met Gly Tyr Gln Gln Ala Glu Asp Ser Glu Glu Asp Lys Lys Phe 
            420                 425                 430         


Leu Thr Gly Tyr Asp Gly Ile Ile His Ala Glu Leu Val Val Ile Asp 
        435                 440                 445             


Asp Glu Glu Glu Glu Asp Glu Gly Glu Ala Glu Lys Pro Ser Tyr His 
    450                 455                 460                 


Pro Ile Ala Pro His Ser Gln Val Tyr Gln Pro Ala Lys Pro Thr Pro 
465                 470                 475                 480 


Leu Pro Arg Lys Arg Ser Glu Ala Ser Pro His Glu Asn Thr Asn His 
                485                 490                 495     


Lys Ser Pro His Lys Asn Ser Ile Ser Leu Lys Glu Gln Glu Glu Ser 
            500                 505                 510         


Leu Gly Ser Pro Val His His Ser Pro Phe Asp Ala Gln Thr Thr Gly 
        515                 520                 525             


Asp Gly Thr Glu Asp Pro Ser Leu Thr Ala Leu Arg Met Arg Met Ala 
    530                 535                 540                 


Lys Leu Gly Lys Lys Val Ile 
545                 550     


<210> 4930
<211> 566
<212> PRT
<213> Homo sapiens

<400> 4930
Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
            180                 185                 190         


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
        195                 200                 205             


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
    210                 215                 220                 


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
225                 230                 235                 240 


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
                245                 250                 255     


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
            260                 265                 270         


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
        275                 280                 285             


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
    290                 295                 300                 


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
305                 310                 315                 320 


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
                325                 330                 335     


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
            340                 345                 350         


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
        355                 360                 365             


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
    370                 375                 380                 


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
385                 390                 395                 400 


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
                405                 410                 415     


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
            420                 425                 430         


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
        435                 440                 445             


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
    450                 455                 460                 


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
465                 470                 475                 480 


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
                485                 490                 495     


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
            500                 505                 510         


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
        515                 520                 525             


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
    530                 535                 540                 


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
545                 550                 555                 560 


Leu Ile Ser Leu Leu Ser 
                565     


<210> 4931
<211> 486
<212> PRT
<213> Homo sapiens

<400> 4931
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 
145                 150                 155                 160 


Ala Ala Cys Lys Glu Glu Lys Leu Ala Ile Ser Arg Glu Ala Asn Ser 
                165                 170                 175     


Lys Ala Asp Pro Ser Leu Asn Pro Glu Gln Leu Lys Lys Leu Gln Asp 
            180                 185                 190         


Lys Ile Glu Lys Cys Lys Gln Asp Val Leu Lys Thr Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ser Leu Lys Glu Leu Asp Gln Gly Thr Pro Gln Tyr Met Glu 
    210                 215                 220                 


Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys Arg 
225                 230                 235                 240 


Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gln Lys His Leu Asp 
                245                 250                 255     


Leu Ser Asn Val Ala Gly Tyr Lys Ala Ile Tyr His Asp Leu Glu Gln 
            260                 265                 270         


Ser Ile Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala 
        275                 280                 285             


Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp 
    290                 295                 300                 


Ser Ala Asp Leu Asn Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 
305                 310                 315                 320 


Thr Asp Gly Val Thr Leu Thr Gly Ile Asn Gln Thr Gly Asp Gln Ser 
                325                 330                 335     


Leu Pro Ser Lys Pro Ser Ser Thr Leu Asn Val Pro Ser Asn Pro Ala 
            340                 345                 350         


Gln Ser Ala Gln Ser Gln Ser Ser Tyr Asn Pro Phe Glu Asp Glu Asp 
        355                 360                 365             


Asp Thr Gly Ser Thr Val Ser Glu Lys Asp Asp Thr Lys Ala Lys Asn 
    370                 375                 380                 


Val Ser Ser Tyr Glu Lys Thr Gln Ser Tyr Pro Thr Asp Trp Ser Asp 
385                 390                 395                 400 


Asp Glu Ser Asn Asn Pro Phe Ser Ser Thr Asp Ala Asn Gly Asp Ser 
                405                 410                 415     


Asn Pro Phe Asp Asp Asp Ala Thr Ser Gly Thr Glu Val Arg Val Arg 
            420                 425                 430         


Ala Leu Tyr Asp Tyr Glu Gly Gln Glu His Asp Glu Leu Ser Phe Lys 
        435                 440                 445             


Ala Gly Asp Glu Leu Thr Lys Met Glu Asp Glu Asp Glu Gln Gly Trp 
    450                 455                 460                 


Cys Lys Gly Arg Leu Asp Asn Gly Gln Val Gly Leu Tyr Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Glu Ala Ile Gln 
                485     


<210> 4932
<211> 753
<212> PRT
<213> Homo sapiens

<400> 4932
Met Met Glu Glu Arg Ala Ala Ala Ala Val Ala Ala Ala Ala Ser Ser 
1               5                   10                  15      


Cys Arg Pro Leu Gly Ser Gly Ala Gly Pro Gly Pro Thr Gly Ala Ala 
            20                  25                  30          


Pro Val Ser Ala Pro Ala Pro Gly Pro Gly Pro Ala Gly Lys Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Ser Pro Gly Pro Thr Ala Gly Pro Glu Pro Leu Ser 
    50                  55                  60                  


Leu Pro Gly Ile Leu His Phe Ile Gln His Glu Trp Ala Arg Phe Glu 
65                  70                  75                  80  


Ala Glu Lys Ala Arg Trp Glu Ala Glu Arg Ala Glu Leu Gln Ala Gln 
                85                  90                  95      


Val Ala Phe Leu Gln Gly Glu Arg Lys Gly Gln Glu Asn Leu Lys Thr 
            100                 105                 110         


Asp Leu Val Arg Arg Ile Lys Met Leu Glu Tyr Ala Leu Lys Gln Glu 
        115                 120                 125             


Arg Ala Lys Tyr His Lys Leu Lys Phe Gly Thr Asp Leu Asn Gln Gly 
    130                 135                 140                 


Glu Lys Lys Ala Asp Val Ser Glu Gln Val Ser Asn Gly Pro Val Glu 
145                 150                 155                 160 


Ser Val Thr Leu Glu Asn Ser Pro Leu Val Trp Lys Glu Gly Arg Gln 
                165                 170                 175     


Leu Leu Arg Gln Tyr Leu Glu Glu Val Gly Tyr Thr Asp Thr Ile Leu 
            180                 185                 190         


Asp Met Arg Ser Lys Arg Val Arg Ser Leu Leu Gly Arg Ser Leu Glu 
        195                 200                 205             


Leu Asn Gly Ala Val Glu Pro Ser Glu Gly Ala Pro Arg Ala Pro Pro 
    210                 215                 220                 


Gly Pro Ala Gly Leu Ser Gly Gly Glu Ser Leu Leu Val Lys Gln Ile 
225                 230                 235                 240 


Glu Glu Gln Ile Lys Arg Asn Ala Ala Gly Lys Asp Gly Lys Glu Arg 
                245                 250                 255     


Leu Gly Gly Ser Val Leu Gly Gln Ile Pro Phe Leu Gln Asn Cys Glu 
            260                 265                 270         


Asp Glu Asp Ser Asp Glu Asp Asp Glu Leu Asp Ser Val Gln His Lys 
        275                 280                 285             


Lys Gln Arg Val Lys Leu Pro Ser Lys Ala Leu Val Pro Glu Met Glu 
    290                 295                 300                 


Asp Glu Asp Glu Glu Asp Asp Ser Glu Asp Ala Ile Asn Glu Phe Asp 
305                 310                 315                 320 


Phe Leu Gly Ser Gly Glu Asp Gly Glu Gly Ala Pro Asp Pro Arg Arg 
                325                 330                 335     


Cys Thr Val Asp Gly Ser Pro His Glu Leu Glu Ser Arg Arg Val Lys 
            340                 345                 350         


Leu Gln Gly Ile Leu Ala Asp Leu Arg Asp Val Asp Gly Leu Pro Pro 
        355                 360                 365             


Lys Val Thr Gly Pro Pro Pro Gly Thr Pro Gln Pro Arg Pro His Glu 
    370                 375                 380                 


Asp Val Phe Ile Met Asp Thr Ile Gly Gly Gly Glu Val Ser Leu Gly 
385                 390                 395                 400 


Asp Leu Ala Asp Leu Thr Val Thr Asn Asp Asn Asp Leu Ser Cys Asp 
                405                 410                 415     


Leu Ser Asp Ser Lys Asp Ala Phe Lys Lys Thr Trp Asn Pro Lys Phe 
            420                 425                 430         


Thr Leu Arg Ser His Tyr Asp Gly Ile Arg Ser Leu Ala Phe His His 
        435                 440                 445             


Ser Gln Ser Ala Leu Leu Thr Ala Ser Glu Asp Gly Thr Leu Lys Leu 
    450                 455                 460                 


Trp Asn Leu Gln Lys Ala Val Thr Ala Lys Lys Asn Ala Ala Leu Asp 
465                 470                 475                 480 


Val Glu Pro Ile His Ala Phe Arg Ala His Arg Gly Pro Val Leu Ala 
                485                 490                 495     


Val Ala Met Gly Ser Asn Ser Glu Tyr Cys Tyr Ser Gly Gly Ala Asp 
            500                 505                 510         


Ala Cys Ile His Ser Trp Lys Ile Pro Asp Leu Ser Met Asp Pro Tyr 
        515                 520                 525             


Asp Gly Tyr Asp Pro Ser Val Leu Ser His Val Leu Glu Gly His Gly 
    530                 535                 540                 


Asp Ala Val Trp Gly Leu Ala Phe Ser Pro Thr Ser Gln Arg Leu Ala 
545                 550                 555                 560 


Ser Cys Ser Ala Asp Gly Thr Val Arg Ile Trp Asp Pro Ser Ser Ser 
                565                 570                 575     


Ser Pro Ala Cys Leu Cys Thr Phe Pro Thr Ala Ser Glu His Gly Val 
            580                 585                 590         


Pro Thr Ser Val Ala Phe Thr Ser Thr Glu Pro Ala His Ile Val Ala 
        595                 600                 605             


Ser Phe Arg Ser Gly Asp Thr Val Leu Tyr Asp Met Glu Val Gly Ser 
    610                 615                 620                 


Ala Leu Leu Thr Leu Glu Ser Arg Gly Ser Ser Gly Pro Thr Gln Ile 
625                 630                 635                 640 


Asn Gln Val Val Ser His Pro Asn Gln Pro Leu Thr Ile Thr Ala His 
                645                 650                 655     


Asp Asp Arg Gly Ile Arg Phe Leu Asp Asn Arg Thr Gly Lys Pro Val 
            660                 665                 670         


His Ser Met Val Ala His Leu Asp Ala Val Thr Cys Leu Ala Val Asp 
        675                 680                 685             


Pro Asn Gly Ala Phe Leu Met Ser Gly Ser His Asp Cys Ser Leu Arg 
    690                 695                 700                 


Leu Trp Ser Leu Asp Asn Lys Thr Cys Val Gln Glu Ile Thr Ala His 
705                 710                 715                 720 


Arg Lys Lys His Glu Glu Ala Ile His Ala Val Ala Cys His Pro Ser 
                725                 730                 735     


Lys Ala Leu Ile Ala Ser Ala Gly Ala Asp Ala Leu Ala Lys Val Phe 
            740                 745                 750         


Val 
    


<210> 4933
<211> 531
<212> PRT
<213> Homo sapiens

<400> 4933
Met Arg Met His Thr Arg Leu Ser Leu Pro Gly Pro Pro His His Val 
1               5                   10                  15      


Gly Ala Ala Tyr Pro Pro Ala Gly Gly Asn Arg Ser Glu Asn Ala Gly 
            20                  25                  30          


Ser Trp Gly Gly Ala Gly Ala Ser Ser Val Glu Pro Leu Ala Arg Arg 
        35                  40                  45              


Val Ala Ser Gly Glu Ala Thr Leu Ala Met Asp Gln Pro Ala Gly Leu 
    50                  55                  60                  


Gln Val Asp Tyr Val Phe Arg Gly Val Glu His Ala Val Arg Val Met 
65                  70                  75                  80  


Val Ser Gly Gln Val Leu Glu Leu Glu Val Glu Asp Arg Met Thr Ala 
                85                  90                  95      


Asp Gln Trp Arg Gly Glu Phe Asp Ala Gly Phe Ile Glu Asp Leu Thr 
            100                 105                 110         


His Lys Thr Gly Asn Phe Lys Gln Phe Asn Ile Phe Cys His Met Leu 
        115                 120                 125             


Glu Ser Ala Leu Thr Gln Ser Ser Glu Ser Val Thr Leu Asp Leu Leu 
    130                 135                 140                 


Thr Tyr Thr Asp Leu Glu Ser Leu Arg Asn Arg Lys Met Gly Gly Arg 
145                 150                 155                 160 


Pro Gly Ser Leu Ala Pro Arg Ser Ala Gln Leu Asn Ser Lys Arg Tyr 
                165                 170                 175     


Leu Ile Leu Ile Tyr Ser Val Glu Phe Asp Arg Ile His Tyr Pro Leu 
            180                 185                 190         


Pro Leu Pro Tyr Gln Gly Lys Pro Asp Pro Val Val Leu Gln Gly Ile 
        195                 200                 205             


Ile Arg Ser Leu Lys Glu Glu Leu Gly Arg Leu Gln Gly Leu Asp Gly 
    210                 215                 220                 


Gln Asn Thr Arg Asp Thr Arg Glu Asn Glu Ile Trp His Leu Arg Glu 
225                 230                 235                 240 


Gln Val Ser Arg Leu Ala Ser Glu Lys Arg Glu Leu Glu Ala Gln Leu 
                245                 250                 255     


Gly Arg Ser Arg Glu Glu Ala Leu Ala Gly Arg Ala Ala Arg Gln Glu 
            260                 265                 270         


Ala Glu Ala Leu Arg Gly Leu Val Arg Gly Leu Glu Leu Glu Leu Arg 
        275                 280                 285             


Gln Glu Arg Gly Leu Gly His Arg Val Ala Gly Arg Arg Gly Gln Asp 
    290                 295                 300                 


Cys Arg Arg Leu Ala Lys Glu Leu Glu Glu Ala Lys Ala Ser Glu Arg 
305                 310                 315                 320 


Ser Leu Arg Ala Arg Leu Lys Thr Leu Thr Ser Glu Leu Ala Leu Tyr 
                325                 330                 335     


Lys Arg Gly Gly Arg Gly Ser Arg Gly Arg Gly Arg Pro Ala Arg Pro 
            340                 345                 350         


Ser Pro Ser Pro Thr Gly Gly Arg Ala Leu Arg Phe Asp Pro Thr Ala 
        355                 360                 365             


Phe Val Lys Ala Lys Glu Arg Lys Gln Arg Glu Ile Gln Met Lys Gln 
    370                 375                 380                 


Gln Gln Arg Asn Arg Leu Gly Ser Gly Gly Ser Gly Asp Gly Pro Ser 
385                 390                 395                 400 


Val Ser Trp Ser Arg Gln Thr Gln Pro Pro Ala Ala Leu Thr Gly Arg 
                405                 410                 415     


Gly Asp Ala Pro Asn Arg Ser Arg Asn Arg Ser Ser Ser Val Asp Ser 
            420                 425                 430         


Phe Arg Ser Arg Cys Ser Ser Ala Ser Ser Cys Ser Asp Leu Glu Asp 
        435                 440                 445             


Phe Ser Glu Ser Leu Ser Arg Gly Gly His Arg Arg Arg Gly Lys Pro 
    450                 455                 460                 


Pro Ser Pro Thr Pro Trp Ser Gly Ser Asn Met Lys Ser Pro Pro Val 
465                 470                 475                 480 


Glu Arg Ser His His Gln Lys Ser Leu Ala Asn Ser Gly Gly Trp Val 
                485                 490                 495     


Pro Ile Lys Glu Tyr Ser Ser Glu His Gln Ala Ala Asp Met Ala Glu 
            500                 505                 510         


Ile Asp Ala Arg Leu Lys Ala Leu Gln Glu Tyr Met Asn Arg Leu Asp 
        515                 520                 525             


Met Arg Ser 
    530     


<210> 4934
<211> 483
<212> PRT
<213> Homo sapiens

<400> 4934
Met Ala Ser Leu Leu Trp Gly Gly Asp Ala Gly Ala Ala Glu Ser Glu 
1               5                   10                  15      


Arg Leu Asn Ser His Phe Ser Asn Leu Ser Gln Pro Arg Lys Asn Leu 
            20                  25                  30          


Trp Gly Ile Lys Ser Thr Ala Val Arg Asn Ile Asp Gly Ser Ile Asn 
        35                  40                  45              


Asn Ile Asn Glu Asp Asp Glu Glu Asp Val Val Asp Leu Ala Ala Asn 
    50                  55                  60                  


Ser Leu Leu Asn Lys Leu Ile His Gln Ser Leu Val Glu Ser Ser His 
65                  70                  75                  80  


Arg Val Glu Val Leu Gln Lys Asp Pro Ser Ser Pro Leu Tyr Ser Val 
                85                  90                  95      


Lys Thr Phe Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile 
            100                 105                 110         


Tyr Ala Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu 
        115                 120                 125             


Pro Met Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln 
    130                 135                 140                 


Ser Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg 
145                 150                 155                 160 


Val Asn Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr 
                165                 170                 175     


Tyr Glu Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys 
            180                 185                 190         


Phe Cys Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile 
        195                 200                 205             


Pro Arg Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly 
    210                 215                 220                 


Thr Val Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys 
225                 230                 235                 240 


Ile Arg Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln 
                245                 250                 255     


Gly Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu 
            260                 265                 270         


Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His 
        275                 280                 285             


Phe Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys 
    290                 295                 300                 


Glu Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu 
305                 310                 315                 320 


His Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile 
                325                 330                 335     


Thr Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys 
            340                 345                 350         


Trp Leu Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu 
        355                 360                 365             


Ser Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe 
    370                 375                 380                 


Arg Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg 
385                 390                 395                 400 


Gly Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro 
                405                 410                 415     


Val Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile 
            420                 425                 430         


Gly Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile 
        435                 440                 445             


Glu Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn 
    450                 455                 460                 


Ser Ser Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys 
465                 470                 475                 480 


Ile Asp Tyr 
            


<210> 4935
<211> 337
<212> PRT
<213> Homo sapiens

<400> 4935
Met Ala Asp Ala Ala Pro Gln Leu Gly Lys Arg Lys Arg Glu Leu Asp 
1               5                   10                  15      


Val Glu Glu Ala His Ala Ala Ser Thr Glu Glu Lys Glu Ala Gly Val 
            20                  25                  30          


Gly Asn Gly Thr Cys Ala Pro Val Arg Leu Pro Phe Ser Gly Phe Arg 
        35                  40                  45              


Leu Gln Lys Val Leu Arg Glu Ser Ala Arg Asp Lys Ile Ile Phe Leu 
    50                  55                  60                  


His Gly Lys Val Asn Glu Ala Ser Gly Asp Gly Asp Gly Glu Asp Ala 
65                  70                  75                  80  


Val Val Ile Leu Glu Lys Thr Pro Phe Gln Val Glu Gln Val Ala Gln 
                85                  90                  95      


Leu Leu Thr Gly Ser Pro Glu Leu Gln Leu Gln Phe Ser Asn Asp Ile 
            100                 105                 110         


Tyr Ser Thr Tyr His Leu Phe Pro Pro Arg Gln Leu Asn Asp Val Lys 
        115                 120                 125             


Thr Thr Val Val Tyr Pro Ala Thr Glu Lys His Leu Gln Lys Tyr Leu 
    130                 135                 140                 


Arg Gln Asp Leu Arg Leu Ile Arg Glu Thr Gly Asp Asp Tyr Arg Asn 
145                 150                 155                 160 


Ile Thr Leu Pro His Leu Glu Ser Gln Ser Leu Ser Ile Gln Trp Val 
                165                 170                 175     


Tyr Asn Ile Leu Asp Lys Lys Ala Glu Ala Asp Arg Ile Val Phe Glu 
            180                 185                 190         


Asn Pro Asp Pro Ser Asp Gly Phe Val Leu Ile Pro Asp Leu Lys Trp 
        195                 200                 205             


Asn Gln Gln Gln Leu Asp Asp Leu Tyr Leu Ile Ala Ile Cys His Arg 
    210                 215                 220                 


Arg Gly Ile Arg Ser Leu Arg Asp Leu Thr Pro Glu His Leu Pro Leu 
225                 230                 235                 240 


Leu Arg Asn Ile Leu His Gln Gly Gln Glu Ala Ile Leu Gln Arg Tyr 
                245                 250                 255     


Arg Met Lys Gly Asp His Leu Arg Val Tyr Leu His Tyr Leu Pro Ser 
            260                 265                 270         


Tyr Tyr His Leu His Val His Phe Thr Ala Leu Gly Phe Glu Ala Pro 
        275                 280                 285             


Gly Ser Gly Val Glu Arg Ala His Leu Leu Ala Glu Val Ile Glu Asn 
    290                 295                 300                 


Leu Glu Cys Asp Pro Arg His Tyr Gln Gln Arg Thr Leu Thr Phe Ala 
305                 310                 315                 320 


Leu Arg Ala Asp Asp Pro Leu Leu Lys Leu Leu Gln Glu Ala Gln Gln 
                325                 330                 335     


Ser 
    


<210> 4936
<211> 593
<212> PRT
<213> Homo sapiens

<400> 4936
Met Lys Leu Gln Ala Val Met Glu Thr Leu Leu Gln Arg Gln Gln Arg 
1               5                   10                  15      


Ala Arg Gln Glu Leu Glu Ala Arg Gln Gln Leu Pro Pro Asp Pro Pro 
            20                  25                  30          


Ala Ala Pro Pro Gly Arg Ala Arg Ala Ala Pro Asp Glu Asp Arg Glu 
        35                  40                  45              


Pro Glu Ser Ala Arg Met Gln Arg Ala Gln Met Ala Ala Leu Ala Ala 
    50                  55                  60                  


Met Arg Ala Ala Ala Ala Gly Leu Gly His Pro Ala Ser Pro Gly Gly 
65                  70                  75                  80  


Ser Glu Asp Gly Pro Pro Gly Ser Glu Glu Glu Asp Ala Ala Arg Glu 
                85                  90                  95      


Gly Thr Pro Gly Ser Pro Gly Arg Gly Arg Glu Gly Pro Gly Glu Glu 
            100                 105                 110         


His Phe Glu Asp Met Ala Ser Asp Glu Asp Met Lys Pro Lys Trp Glu 
        115                 120                 125             


Glu Glu Glu Met Glu Glu Asp Leu Gly Glu Asp Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Asp Tyr Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Gly Leu Gly 
145                 150                 155                 160 


Pro Pro Gly Pro Ala Ser Leu Gly Thr Thr Ala Leu Phe Pro Arg Lys 
                165                 170                 175     


Ala Gln Pro Pro Gln Ala Phe Arg Gly Asp Gly Val Pro Arg Val Leu 
            180                 185                 190         


Gly Gly Gln Glu Arg Pro Gly Pro Gly Pro Ala His Pro Gly Gly Ala 
        195                 200                 205             


Ala His Val Ala Pro Gln Leu Gln Pro Pro Asp His Gly Asp Trp Thr 
    210                 215                 220                 


Tyr Glu Glu Gln Phe Lys Gln Leu Tyr Glu Leu Asp Gly Asp Pro Lys 
225                 230                 235                 240 


Arg Lys Glu Phe Leu Asp Asp Leu Phe Ser Phe Met Gln Lys Arg Gly 
                245                 250                 255     


Thr Pro Val Asn Arg Ile Pro Ile Met Ala Lys Gln Val Leu Asp Leu 
            260                 265                 270         


Phe Met Leu Tyr Val Leu Val Thr Glu Lys Gly Gly Leu Val Glu Val 
        275                 280                 285             


Ile Asn Lys Lys Leu Trp Arg Glu Ile Thr Lys Gly Leu Asn Leu Pro 
    290                 295                 300                 


Thr Ser Ile Thr Ser Ala Ala Phe Thr Leu Arg Thr Gln Tyr Met Lys 
305                 310                 315                 320 


Tyr Leu Tyr Pro Tyr Glu Cys Glu Lys Arg Gly Leu Ser Asn Pro Asn 
                325                 330                 335     


Glu Leu Gln Ala Ala Ile Asp Ser Asn Arg Arg Glu Gly Arg Arg Gln 
            340                 345                 350         


Ser Phe Gly Gly Ser Leu Phe Ala Tyr Ser Pro Gly Gly Ala His Gly 
        355                 360                 365             


Met Leu Ser Ser Pro Lys Leu Pro Val Ser Ser Leu Gly Leu Ala Ala 
    370                 375                 380                 


Ser Thr Asn Gly Ser Ser Ile Thr Pro Ala Pro Lys Ile Lys Lys Glu 
385                 390                 395                 400 


Glu Asp Ser Ala Ile Pro Ile Thr Val Pro Gly Arg Leu Pro Val Ser 
                405                 410                 415     


Leu Ala Gly His Pro Val Val Ala Ala Gln Ala Ala Ala Val Gln Ala 
            420                 425                 430         


Ala Ala Ala Gln Ala Ala Val Ala Ala Gln Ala Ala Ala Leu Glu Gln 
        435                 440                 445             


Leu Arg Glu Lys Leu Glu Ser Ala Glu Pro Pro Glu Lys Lys Met Ala 
    450                 455                 460                 


Leu Val Ala Asp Glu Gln Gln Arg Leu Met Gln Arg Ala Leu Gln Gln 
465                 470                 475                 480 


Asn Phe Leu Ala Met Ala Ala Gln Leu Pro Met Ser Ile Arg Ile Asn 
                485                 490                 495     


Ser Gln Ala Ser Glu Ser Arg Gln Asp Ser Ala Val Asn Leu Thr Gly 
            500                 505                 510         


Thr Asn Gly Ser Asn Ser Ile Ser Met Ser Val Glu Ile Asn Gly Ile 
        515                 520                 525             


Met Tyr Thr Gly Val Leu Phe Ala Gln Pro Pro Ala Pro Thr Pro Thr 
    530                 535                 540                 


Ser Ala Pro Asn Lys Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Asn 
545                 550                 555                 560 


Ala Gly Gly Arg Gly Gly Asn Thr Gly Thr Ser Gly Gly Gln Ala Gly 
                565                 570                 575     


Pro Ala Gly Leu Ser Thr Pro Ser Thr Ser Thr Ser Asn Asn Ser Leu 
            580                 585                 590         


Pro 
    


<210> 4937
<211> 2063
<212> PRT
<213> Homo sapiens

<400> 4937
Met Ala Asp Gly Ala Pro Arg Pro Gln Leu Tyr Arg Ser Val Ser Phe 
1               5                   10                  15      


Lys Leu Leu Glu Arg Trp Ser Gly Gly Pro Gly Leu Arg Glu Glu Asp 
            20                  25                  30          


Thr Asp Thr Pro Gly Leu Arg Arg Arg Ala Ser Cys Arg Pro Thr Thr 
        35                  40                  45              


Ala Ala Arg Gly Gln Pro Ser Arg Arg Val Ser Lys Leu Ala Ser Gly 
    50                  55                  60                  


Pro Leu Ala Ala Pro Ala Gln Pro Arg Pro Leu Arg Ser Leu Ser Pro 
65                  70                  75                  80  


Ser Val Arg Gln Leu Ser Arg Arg Phe Asp Ala Pro Arg Leu Asp Asp 
                85                  90                  95      


Gly Ser Ala Gly Thr Arg Asp Gly Gly Val Leu Pro Ala Ala Ala Glu 
            100                 105                 110         


Glu Ala Ala Glu Gly Pro Ala Arg Gly Ala Trp Pro Ser Val Thr Glu 
        115                 120                 125             


Met Arg Lys Leu Phe Gly Gly Pro Gly Ser Arg Arg Pro Ser Ala Asp 
    130                 135                 140                 


Ser Glu Ser Pro Gly Thr Pro Ser Pro Asp Gly Ala Ala Trp Glu Pro 
145                 150                 155                 160 


Pro Ala Arg Glu Ser Arg Gln Pro Pro Thr Pro Pro Pro Arg Thr Cys 
                165                 170                 175     


Phe Pro Leu Ala Gly Leu Arg Ser Ala Arg Pro Leu Thr Gly Pro Glu 
            180                 185                 190         


Thr Glu Gly Arg Leu Arg Arg Pro Gln Gln Gln Gln Glu Arg Ala Gln 
        195                 200                 205             


Arg Pro Ala Asp Gly Leu His Ser Trp His Ile Phe Ser Gln Pro Gln 
    210                 215                 220                 


Ala Gly Ala Arg Ala Ser Cys Ser Ser Ser Ser Ile Ala Ala Ser Tyr 
225                 230                 235                 240 


Pro Val Ser Arg Ser Arg Ala Ala Ser Ser Ser Glu Glu Glu Glu Glu 
                245                 250                 255     


Gly Pro Pro Gln Leu Pro Gly Ala Gln Ser Pro Ala Tyr His Gly Gly 
            260                 265                 270         


His Ser Ser Gly Ser Asp Asp Asp Arg Asp Gly Glu Gly Gly His Arg 
        275                 280                 285             


Trp Gly Gly Arg Pro Gly Leu Arg Pro Gly Ser Ser Leu Leu Asp Gln 
    290                 295                 300                 


Asp Cys Arg Pro Asp Ser Asp Gly Leu Asn Leu Ser Ser Met Asn Ser 
305                 310                 315                 320 


Ala Gly Val Ser Gly Ser Pro Glu Pro Pro Thr Ser Pro Arg Ala Pro 
                325                 330                 335     


Arg Glu Glu Gly Leu Arg Glu Trp Gly Ser Gly Ser Pro Pro Cys Val 
            340                 345                 350         


Pro Gly Pro Gln Glu Gly Leu Arg Pro Met Ser Asp Ser Val Gly Gly 
        355                 360                 365             


Ala Phe Arg Val Ala Lys Val Ser Phe Pro Ser Tyr Leu Ala Ser Pro 
    370                 375                 380                 


Ala Gly Ser Arg Gly Ser Ser Arg Tyr Ser Ser Thr Glu Thr Leu Lys 
385                 390                 395                 400 


Asp Asp Asp Leu Trp Ser Ser Arg Gly Ser Gly Gly Trp Gly Val Tyr 
                405                 410                 415     


Arg Ser Pro Ser Phe Gly Ala Gly Glu Gly Leu Leu Arg Ser Gln Ala 
            420                 425                 430         


Arg Thr Arg Ala Lys Gly Pro Gly Gly Thr Ser Arg Ala Leu Arg Asp 
        435                 440                 445             


Gly Gly Phe Glu Pro Glu Lys Ser Arg Gln Arg Lys Ser Leu Ser Asn 
    450                 455                 460                 


Pro Asp Ile Ala Ser Glu Thr Leu Thr Leu Leu Ser Phe Leu Arg Ser 
465                 470                 475                 480 


Asp Leu Ser Glu Leu Arg Val Arg Lys Pro Gly Gly Ser Ser Gly Asp 
                485                 490                 495     


Arg Gly Ser Asn Pro Leu Asp Gly Arg Asp Ser Pro Ser Ala Gly Gly 
            500                 505                 510         


Pro Val Gly Gln Leu Glu Pro Ile Pro Ile Pro Ala Pro Ala Ser Pro 
        515                 520                 525             


Gly Thr Arg Pro Thr Leu Lys Asp Leu Thr Ala Thr Leu Arg Arg Ala 
    530                 535                 540                 


Lys Ser Phe Thr Cys Ser Glu Lys Pro Met Ala Arg Arg Leu Pro Arg 
545                 550                 555                 560 


Thr Ser Ala Leu Lys Ser Ser Ser Ser Glu Leu Leu Leu Thr Gly Pro 
                565                 570                 575     


Gly Ala Glu Glu Asp Pro Leu Pro Leu Ile Val Gln Asp Gln Tyr Val 
            580                 585                 590         


Gln Glu Ala Arg Gln Val Phe Glu Lys Ile Gln Arg Met Gly Ala Gln 
        595                 600                 605             


Gln Asp Asp Gly Ser Asp Ala Pro Pro Gly Ser Pro Asp Trp Ala Gly 
    610                 615                 620                 


Asp Val Thr Arg Gly Gln Arg Ser Gln Glu Glu Leu Ser Gly Pro Glu 
625                 630                 635                 640 


Ser Ser Leu Thr Asp Glu Gly Ile Gly Ala Asp Pro Glu Pro Pro Val 
                645                 650                 655     


Ala Ala Phe Cys Gly Leu Gly Thr Thr Gly Met Trp Arg Pro Leu Ser 
            660                 665                 670         


Ser Ser Ser Ala Gln Thr Asn His His Gly Pro Gly Thr Glu Asp Ser 
        675                 680                 685             


Leu Gly Gly Trp Ala Leu Val Ser Pro Glu Thr Pro Pro Thr Pro Gly 
    690                 695                 700                 


Ala Leu Arg Arg Arg Arg Lys Val Pro Pro Ser Gly Ser Gly Gly Ser 
705                 710                 715                 720 


Glu Leu Ser Asn Gly Glu Ala Gly Glu Ala Tyr Arg Ser Leu Ser Asp 
                725                 730                 735     


Pro Ile Pro Gln Arg His Arg Ala Ala Thr Ser Glu Glu Pro Thr Gly 
            740                 745                 750         


Phe Ser Val Asp Ser Asn Leu Leu Gly Ser Leu Ser Pro Lys Thr Gly 
        755                 760                 765             


Leu Pro Ala Thr Ser Ala Met Asp Glu Gly Leu Thr Ser Gly His Ser 
    770                 775                 780                 


Asp Trp Ser Val Gly Ser Glu Glu Ser Lys Gly Tyr Gln Glu Val Ile 
785                 790                 795                 800 


Gln Ser Ile Val Gln Gly Pro Gly Thr Leu Gly Arg Val Val Asp Asp 
                805                 810                 815     


Arg Ile Ala Gly Lys Ala Pro Lys Lys Lys Ser Leu Ser Asp Pro Ser 
            820                 825                 830         


Arg Arg Gly Glu Leu Ala Gly Pro Gly Phe Glu Gly Pro Gly Gly Glu 
        835                 840                 845             


Pro Ile Arg Glu Val Glu Pro Met Leu Pro Pro Ser Ser Ser Glu Pro 
    850                 855                 860                 


Ile Leu Val Glu Gln Arg Ala Glu Pro Glu Glu Pro Gly Ala Thr Arg 
865                 870                 875                 880 


Ser Arg Ala Gln Ser Glu Arg Ala Leu Pro Glu Ala Leu Pro Pro Pro 
                885                 890                 895     


Ala Thr Ala His Arg Asn Phe His Leu Asp Pro Lys Leu Ala Asp Ile 
            900                 905                 910         


Leu Ser Pro Arg Leu Ile Arg Arg Gly Ser Lys Lys Arg Pro Ala Arg 
        915                 920                 925             


Ser Ser His Gln Glu Leu Arg Arg Asp Glu Gly Ser Gln Asp Gln Thr 
    930                 935                 940                 


Gly Ser Leu Ser Arg Ala Arg Pro Ser Ser Arg His Val Arg His Ala 
945                 950                 955                 960 


Ser Val Pro Ala Thr Phe Met Pro Ile Val Val Pro Glu Pro Pro Thr 
                965                 970                 975     


Ser Val Gly Pro Pro Val Ala Val Pro Glu Pro Ile Gly Phe Pro Thr 
            980                 985                 990         


Arg Ala His Pro Thr Leu Gln Ala  Pro Ser Leu Glu Asp  Val Thr Lys 
        995                 1000                 1005             


Gln Tyr  Met Leu Asn Leu His  Ser Gly Glu Val Pro  Ala Pro Val 
    1010                 1015                 1020             


Pro Val  Asp Met Pro Cys Leu  Pro Leu Ala Ala Pro  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ala  Lys Pro Pro Glu Ala  Ala Arg Pro Ala Asp  Glu Pro Thr 
    1040                 1045                 1050             


Pro Ala  Ser Lys Cys Cys Ser  Lys Pro Gln Val Asp  Met Arg Lys 
    1055                 1060                 1065             


His Val  Ala Met Thr Leu Leu  Asp Thr Glu Gln Ser  Tyr Val Glu 
    1070                 1075                 1080             


Ser Leu  Arg Thr Leu Met Gln  Gly Tyr Met Gln Pro  Leu Lys Gln 
    1085                 1090                 1095             


Pro Glu  Asn Ser Val Leu Cys  Asp Pro Ser Leu Val  Asp Glu Ile 
    1100                 1105                 1110             


Phe Asp  Gln Ile Pro Glu Leu  Leu Glu His His Glu  Gln Phe Leu 
    1115                 1120                 1125             


Glu Gln  Val Arg His Cys Met  Gln Thr Trp His Ala  Gln Gln Lys 
    1130                 1135                 1140             


Val Gly  Ala Leu Leu Val Gln  Ser Phe Ser Lys Asp  Val Leu Val 
    1145                 1150                 1155             


Asn Ile  Tyr Ser Ala Tyr Ile  Asp Asn Phe Leu Asn  Ala Lys Asp 
    1160                 1165                 1170             


Ala Val  Arg Val Ala Lys Glu  Ala Arg Pro Ala Phe  Leu Lys Phe 
    1175                 1180                 1185             


Leu Glu  Gln Ser Met Arg Glu  Asn Lys Glu Lys Gln  Ala Leu Ser 
    1190                 1195                 1200             


Asp Leu  Met Ile Lys Pro Val  Gln Arg Ile Pro Arg  Tyr Glu Leu 
    1205                 1210                 1215             


Leu Val  Lys Asp Leu Leu Lys  His Thr Pro Glu Asp  His Pro Asp 
    1220                 1225                 1230             


His Pro  Leu Leu Leu Glu Ala  Gln Arg Asn Ile Lys  Gln Val Ala 
    1235                 1240                 1245             


Glu Arg  Ile Asn Lys Gly Val  Arg Ser Ala Glu Glu  Ala Glu Arg 
    1250                 1255                 1260             


His Ala  Arg Val Leu Gln Glu  Ile Glu Ala His Ile  Glu Gly Met 
    1265                 1270                 1275             


Glu Asp  Leu Gln Ala Pro Leu  Arg Arg Phe Leu Arg  Gln Glu Met 
    1280                 1285                 1290             


Val Ile  Glu Val Lys Ala Ile  Gly Gly Lys Lys Asp  Arg Ser Leu 
    1295                 1300                 1305             


Phe Leu  Phe Thr Asp Leu Ile  Val Cys Thr Thr Leu  Lys Arg Lys 
    1310                 1315                 1320             


Ser Gly  Ser Leu Arg Arg Ser  Ser Met Ser Leu Tyr  Thr Ala Ala 
    1325                 1330                 1335             


Ser Val  Ile Asp Thr Ala Ser  Lys Tyr Lys Met Leu  Trp Lys Leu 
    1340                 1345                 1350             


Pro Leu  Glu Asp Ala Asp Ile  Ile Lys Gly Ala Ser  Gln Ala Thr 
    1355                 1360                 1365             


Asn Arg  Glu Asn Ile Gln Lys  Ala Ile Ser Arg Leu  Asp Glu Asp 
    1370                 1375                 1380             


Leu Thr  Thr Leu Gly Gln Met  Ser Lys Leu Ser Glu  Ser Leu Gly 
    1385                 1390                 1395             


Phe Pro  His Gln Ser Leu Asp  Asp Ala Leu Arg Asp  Leu Ser Ala 
    1400                 1405                 1410             


Ala Met  His Arg Asp Leu Ser  Glu Lys Gln Ala Leu  Cys Tyr Ala 
    1415                 1420                 1425             


Leu Ser  Phe Pro Pro Thr Lys  Leu Glu Leu Cys Ala  Thr Arg Pro 
    1430                 1435                 1440             


Glu Gly  Thr Asp Ser Tyr Ile  Phe Glu Phe Pro His  Pro Asp Ala 
    1445                 1450                 1455             


Arg Leu  Gly Phe Glu Gln Ala  Phe Asp Glu Ala Lys  Arg Lys Leu 
    1460                 1465                 1470             


Ala Ser  Ser Lys Ser Cys Leu  Asp Pro Glu Phe Leu  Lys Ala Ile 
    1475                 1480                 1485             


Pro Ile  Met Lys Thr Arg Ser  Gly Met Gln Phe Ser  Cys Ala Ala 
    1490                 1495                 1500             


Pro Thr  Leu Asn Ser Cys Pro  Glu Pro Ser Pro Glu  Val Trp Val 
    1505                 1510                 1515             


Cys Asn  Ser Asp Gly Tyr Val  Gly Gln Val Cys Leu  Leu Ser Leu 
    1520                 1525                 1530             


Arg Ala  Glu Pro Asp Val Glu  Ala Cys Ile Ala Val  Cys Ser Ala 
    1535                 1540                 1545             


Arg Ile  Leu Cys Ile Gly Ala  Val Pro Gly Leu Gln  Pro Arg Cys 
    1550                 1555                 1560             


His Arg  Glu Pro Pro Pro Ser  Leu Arg Ser Pro Pro  Glu Thr Ala 
    1565                 1570                 1575             


Pro Glu  Pro Ala Gly Pro Glu  Leu Asp Val Glu Ala  Ala Ala Asp 
    1580                 1585                 1590             


Glu Glu  Ala Ala Thr Leu Ala  Glu Pro Gly Pro Gln  Pro Cys Leu 
    1595                 1600                 1605             


His Ile  Ser Ile Ala Gly Ser  Gly Leu Glu Met Thr  Pro Gly Leu 
    1610                 1615                 1620             


Gly Glu  Gly Asp Pro Arg Pro  Glu Leu Val Pro Phe  Asp Ser Asp 
    1625                 1630                 1635             


Ser Asp  Asp Glu Ser Ser Pro  Ser Pro Ser Gly Thr  Leu Gln Ser 
    1640                 1645                 1650             


Gln Ala  Ser Arg Ser Thr Ile  Ser Ser Ser Phe Gly  Asn Glu Glu 
    1655                 1660                 1665             


Thr Pro  Ser Ser Lys Glu Ala  Thr Ala Glu Thr Thr  Ser Ser Glu 
    1670                 1675                 1680             


Glu Glu  Gln Glu Pro Gly Phe  Leu Pro Leu Ser Gly  Ser Phe Gly 
    1685                 1690                 1695             


Pro Gly  Gly Pro Cys Gly Thr  Ser Pro Met Asp Gly  Arg Ala Leu 
    1700                 1705                 1710             


Arg Arg  Ser Ser His Gly Ser  Phe Thr Arg Gly Ser  Leu Glu Asp 
    1715                 1720                 1725             


Leu Leu  Ser Val Asp Pro Glu  Ala Tyr Gln Ser Ser  Val Trp Leu 
    1730                 1735                 1740             


Gly Thr  Glu Asp Gly Cys Val  His Val Tyr Gln Ser  Ser Asp Ser 
    1745                 1750                 1755             


Ile Arg  Asp Arg Arg Asn Ser  Met Lys Leu Gln His  Ala Ala Ser 
    1760                 1765                 1770             


Val Thr  Cys Ile Leu Tyr Leu  Asn Asn Gln Val Phe  Val Ser Leu 
    1775                 1780                 1785             


Ala Asn  Gly Glu Leu Val Val  Tyr Gln Arg Glu Ala  Gly His Phe 
    1790                 1795                 1800             


Trp Asp  Pro Gln Asn Phe Lys  Ser Val Thr Leu Gly  Thr Gln Gly 
    1805                 1810                 1815             


Ser Pro  Ile Thr Lys Met Val  Ser Val Gly Gly Arg  Leu Trp Cys 
    1820                 1825                 1830             


Gly Cys  Gln Asn Arg Val Leu  Val Leu Ser Pro Asp  Thr Leu Gln 
    1835                 1840                 1845             


Leu Glu  His Met Phe Tyr Val  Gly Gln Asp Ser Ser  Arg Cys Val 
    1850                 1855                 1860             


Ala Cys  Met Val Asp Ser Ser  Leu Gly Val Trp Val  Thr Leu Lys 
    1865                 1870                 1875             


Gly Ser  Ala His Val Cys Leu  Tyr His Pro Asp Thr  Phe Glu Gln 
    1880                 1885                 1890             


Leu Ala  Glu Val Asp Val Thr  Pro Pro Val His Arg  Met Leu Ala 
    1895                 1900                 1905             


Gly Ser  Asp Ala Ile Ile Arg  Gln His Lys Ala Ala  Cys Leu Arg 
    1910                 1915                 1920             


Ile Thr  Ala Leu Leu Val Cys  Glu Glu Leu Leu Trp  Val Gly Thr 
    1925                 1930                 1935             


Ser Ala  Gly Val Val Leu Thr  Met Pro Thr Ser Pro  Gly Thr Val 
    1940                 1945                 1950             


Ser Cys  Pro Arg Ala Pro Leu  Ser Pro Thr Gly Leu  Gly Gln Gly 
    1955                 1960                 1965             


His Thr  Gly His Val Arg Phe  Leu Ala Ala Val Gln  Leu Pro Asp 
    1970                 1975                 1980             


Gly Phe  Asn Leu Leu Cys Pro  Thr Pro Pro Pro Pro  Pro Asp Thr 
    1985                 1990                 1995             


Gly Pro  Glu Lys Leu Pro Ser  Leu Glu His Arg Asp  Ser Pro Trp 
    2000                 2005                 2010             


His Arg  Gly Pro Ala Pro Ala  Arg Pro Lys Met Leu  Val Ile Ser 
    2015                 2020                 2025             


Gly Gly  Asp Gly Tyr Glu Asp  Phe Arg Leu Ser Ser  Gly Gly Gly 
    2030                 2035                 2040             


Ser Ser  Ser Glu Thr Val Gly  Arg Asp Asp Ser Thr  Asn His Leu 
    2045                 2050                 2055             


Leu Leu  Trp Arg Val 
    2060             


<210> 4938
<211> 832
<212> PRT
<213> Homo sapiens

<400> 4938
Met Ser Glu Ala Gly Gly Ala Gly Pro Gly Gly Cys Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Pro Gly Ala Leu Pro Pro Gln Pro Ala Ala Leu 
            20                  25                  30          


Pro Pro Ala Pro Pro Gln Gly Ser Pro Cys Ala Ala Ala Ala Gly Gly 
        35                  40                  45              


Ser Gly Ala Cys Gly Pro Ala Thr Ala Val Ala Ala Ala Gly Thr Ala 
    50                  55                  60                  


Glu Gly Pro Gly Gly Gly Gly Ser Ala Arg Ile Ala Val Lys Lys Ala 
65                  70                  75                  80  


Gln Leu Arg Ser Ala Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val 
                85                  90                  95      


Tyr Ser Ala Cys Lys Ala Glu Glu Ser Cys Lys Cys Asn Gly Trp Lys 
            100                 105                 110         


Asn Pro Asn Pro Ser Pro Thr Pro Pro Arg Ala Asp Leu Gln Gln Ile 
        115                 120                 125             


Ile Val Ser Leu Thr Glu Ser Cys Arg Ser Cys Ser His Ala Leu Ala 
    130                 135                 140                 


Ala His Val Ser His Leu Glu Asn Val Ser Glu Glu Glu Met Asn Arg 
145                 150                 155                 160 


Leu Leu Gly Ile Val Leu Asp Val Glu Tyr Leu Phe Thr Cys Val His 
                165                 170                 175     


Lys Glu Glu Asp Ala Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys 
            180                 185                 190         


Leu Leu Arg Lys Ser Ile Leu Gln Arg Gly Lys Pro Val Val Glu Gly 
        195                 200                 205             


Ser Leu Glu Lys Lys Pro Pro Phe Glu Lys Pro Ser Ile Glu Gln Gly 
    210                 215                 220                 


Val Asn Asn Phe Val Gln Tyr Lys Phe Ser His Leu Pro Ala Lys Glu 
225                 230                 235                 240 


Arg Gln Thr Ile Val Glu Leu Ala Lys Met Phe Leu Asn Arg Ile Asn 
                245                 250                 255     


Tyr Trp His Leu Glu Ala Pro Ser Gln Arg Arg Leu Arg Ser Pro Asn 
            260                 265                 270         


Asp Asp Ile Ser Gly Tyr Lys Glu Asn Tyr Thr Arg Trp Leu Cys Tyr 
        275                 280                 285             


Cys Asn Val Pro Gln Phe Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr 
    290                 295                 300                 


Gln Val Phe Gly Arg Thr Leu Leu Arg Ser Val Phe Thr Val Met Arg 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Gln Ala Arg Gln Glu Lys Asp Lys Leu Pro Leu 
                325                 330                 335     


Glu Lys Arg Thr Leu Ile Leu Thr His Phe Pro Lys Phe Leu Ser Met 
            340                 345                 350         


Leu Glu Glu Glu Val Tyr Ser Gln Asn Ser Pro Ile Trp Asp Gln Asp 
        355                 360                 365             


Phe Leu Ser Ala Ser Ser Arg Thr Ser Gln Leu Gly Ile Gln Thr Val 
    370                 375                 380                 


Ile Asn Pro Pro Pro Val Ala Gly Thr Ile Ser Tyr Asn Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Leu Glu Gln Pro Asn Ala Gly Ser Ser Ser Pro Ala Cys Lys 
                405                 410                 415     


Ala Ser Ser Gly Leu Glu Ala Asn Pro Gly Glu Lys Arg Lys Met Thr 
            420                 425                 430         


Asp Ser His Val Leu Glu Glu Ala Lys Lys Pro Arg Val Met Gly Asp 
        435                 440                 445             


Ile Pro Met Glu Leu Ile Asn Glu Val Met Ser Thr Ile Thr Asp Pro 
    450                 455                 460                 


Ala Ala Met Leu Gly Pro Glu Thr Asn Phe Leu Ser Ala His Ser Ala 
465                 470                 475                 480 


Arg Asp Glu Ala Ala Arg Leu Glu Glu Arg Arg Gly Val Ile Glu Phe 
                485                 490                 495     


His Val Val Gly Asn Ser Leu Asn Gln Lys Pro Asn Lys Lys Ile Leu 
            500                 505                 510         


Met Trp Leu Val Gly Leu Gln Asn Val Phe Ser His Gln Leu Pro Arg 
        515                 520                 525             


Met Pro Lys Glu Tyr Ile Thr Arg Leu Val Phe Asp Pro Lys His Lys 
    530                 535                 540                 


Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile Gly Gly Ile Cys Phe 
545                 550                 555                 560 


Arg Met Phe Pro Ser Gln Gly Phe Thr Glu Ile Val Phe Cys Ala Val 
                565                 570                 575     


Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr His Leu Met Asn His 
            580                 585                 590         


Leu Lys Glu Tyr His Ile Lys His Asp Ile Leu Asn Phe Leu Thr Tyr 
        595                 600                 605             


Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys Gln Gly Phe Ser Lys 
    610                 615                 620                 


Glu Ile Lys Ile Pro Lys Thr Lys Tyr Val Gly Tyr Ile Lys Asp Tyr 
625                 630                 635                 640 


Glu Gly Ala Thr Leu Met Gly Cys Glu Leu Asn Pro Arg Ile Pro Tyr 
                645                 650                 655     


Thr Glu Phe Ser Val Ile Ile Lys Lys Gln Lys Glu Ile Ile Lys Lys 
            660                 665                 670         


Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys Val Tyr Pro Gly Leu 
        675                 680                 685             


Ser Cys Phe Lys Asp Gly Val Arg Gln Ile Pro Ile Glu Ser Ile Pro 
    690                 695                 700                 


Gly Ile Arg Glu Thr Gly Trp Lys Pro Ser Gly Lys Glu Lys Ser Lys 
705                 710                 715                 720 


Glu Pro Arg Asp Pro Asp Gln Leu Tyr Ser Thr Leu Lys Ser Ile Leu 
                725                 730                 735     


Gln Gln Val Lys Ser His Gln Ser Ala Trp Pro Phe Met Glu Pro Val 
            740                 745                 750         


Lys Arg Thr Glu Ala Pro Gly Tyr Tyr Glu Val Ile Arg Phe Pro Met 
        755                 760                 765             


Asp Leu Lys Thr Met Ser Glu Arg Leu Lys Asn Arg Tyr Tyr Val Ser 
    770                 775                 780                 


Lys Lys Leu Phe Met Ala Asp Leu Gln Arg Val Phe Thr Asn Cys Lys 
785                 790                 795                 800 


Glu Tyr Asn Pro Pro Glu Ser Glu Tyr Tyr Lys Cys Ala Asn Ile Leu 
                805                 810                 815     


Glu Lys Phe Phe Phe Ser Lys Ile Lys Glu Ala Gly Leu Ile Asp Lys 
            820                 825                 830         


<210> 4939
<211> 1649
<212> PRT
<213> Homo sapiens

<400> 4939
Met Ala Gly Gly Arg Gly Ala Pro Gly Arg Gly Arg Asp Glu Pro Pro 
1               5                   10                  15      


Glu Ser Tyr Pro Gln Arg Gln Asp His Glu Leu Gln Ala Leu Glu Ala 
            20                  25                  30          


Ile Tyr Gly Ala Asp Phe Gln Asp Leu Arg Pro Asp Ala Cys Gly Pro 
        35                  40                  45              


Val Lys Glu Pro Pro Glu Ile Asn Leu Val Leu Tyr Pro Gln Gly Leu 
    50                  55                  60                  


Thr Gly Glu Glu Val Tyr Val Lys Val Asp Leu Arg Val Lys Cys Pro 
65                  70                  75                  80  


Pro Thr Tyr Pro Asp Val Val Pro Glu Ile Glu Leu Lys Asn Ala Lys 
                85                  90                  95      


Gly Leu Ser Asn Glu Ser Val Asn Leu Leu Lys Ser Arg Leu Glu Glu 
            100                 105                 110         


Leu Ala Lys Lys His Cys Gly Glu Val Met Ile Phe Glu Leu Ala Tyr 
        115                 120                 125             


His Val Gln Ser Phe Leu Ser Glu His Asn Lys Pro Pro Pro Lys Ser 
    130                 135                 140                 


Phe His Glu Glu Met Leu Glu Arg Arg Ala Gln Glu Glu Gln Gln Arg 
145                 150                 155                 160 


Leu Leu Glu Ala Lys Arg Lys Glu Glu Gln Glu Gln Arg Glu Ile Leu 
                165                 170                 175     


His Glu Ile Gln Arg Arg Lys Glu Glu Ile Lys Glu Glu Lys Lys Arg 
            180                 185                 190         


Lys Glu Met Ala Lys Gln Glu Arg Leu Glu Ile Ala Ser Leu Ser Asn 
        195                 200                 205             


Gln Asp His Thr Ser Lys Lys Asp Pro Gly Gly His Arg Thr Ala Ala 
    210                 215                 220                 


Ile Leu His Gly Gly Ser Pro Asp Phe Val Gly Asn Gly Lys His Arg 
225                 230                 235                 240 


Ala Asn Ser Ser Gly Arg Ser Arg Arg Glu Arg Gln Tyr Ser Val Cys 
                245                 250                 255     


Asn Ser Glu Asp Ser Pro Gly Ser Cys Glu Ile Leu Tyr Phe Asn Met 
            260                 265                 270         


Gly Ser Pro Asp Gln Leu Met Val His Lys Gly Lys Cys Ile Gly Ser 
        275                 280                 285             


Asp Glu Gln Leu Gly Lys Leu Val Tyr Asn Ala Leu Glu Thr Ala Thr 
    290                 295                 300                 


Gly Gly Phe Val Leu Leu Tyr Glu Trp Val Leu Gln Trp Gln Lys Lys 
305                 310                 315                 320 


Met Gly Pro Phe Leu Thr Ser Gln Glu Lys Glu Lys Ile Asp Lys Cys 
                325                 330                 335     


Lys Lys Gln Ile Gln Gly Thr Glu Thr Glu Phe Asn Ser Leu Val Lys 
            340                 345                 350         


Leu Ser His Pro Asn Val Val Arg Tyr Leu Ala Met Asn Leu Lys Glu 
        355                 360                 365             


Gln Asp Asp Ser Ile Val Val Asp Ile Leu Val Glu His Ile Ser Gly 
    370                 375                 380                 


Val Ser Leu Ala Ala His Leu Ser His Ser Gly Pro Ile Pro Val His 
385                 390                 395                 400 


Gln Leu Arg Arg Tyr Thr Ala Gln Leu Leu Ser Gly Leu Asp Tyr Leu 
                405                 410                 415     


His Ser Asn Ser Val Val His Lys Val Leu Ser Ala Ser Asn Val Leu 
            420                 425                 430         


Val Asp Ala Glu Gly Thr Val Lys Ile Thr Asp Tyr Ser Ile Ser Lys 
        435                 440                 445             


Arg Leu Ala Asp Ile Cys Lys Glu Asp Val Phe Glu Gln Thr Arg Val 
    450                 455                 460                 


Arg Phe Ser Asp Asn Ala Leu Pro Tyr Lys Thr Gly Lys Lys Gly Asp 
465                 470                 475                 480 


Val Trp Arg Leu Gly Leu Leu Leu Leu Ser Leu Ser Gln Gly Gln Glu 
                485                 490                 495     


Cys Gly Glu Tyr Pro Val Thr Ile Pro Ser Asp Leu Pro Ala Asp Phe 
            500                 505                 510         


Gln Asp Phe Leu Lys Lys Cys Val Cys Leu Asp Asp Lys Glu Arg Trp 
        515                 520                 525             


Ser Pro Gln Gln Leu Leu Lys His Ser Phe Ile Asn Pro Gln Pro Lys 
    530                 535                 540                 


Met Pro Leu Val Glu Gln Ser Pro Glu Asp Ser Glu Gly Gln Asp Tyr 
545                 550                 555                 560 


Val Glu Thr Val Ile Pro Ser Asn Arg Leu Pro Ser Ala Ala Phe Phe 
                565                 570                 575     


Ser Glu Thr Gln Arg Gln Phe Ser Arg Tyr Phe Ile Glu Phe Glu Glu 
            580                 585                 590         


Leu Gln Leu Leu Gly Lys Gly Ala Phe Gly Ala Val Ile Lys Val Gln 
        595                 600                 605             


Asn Lys Leu Asp Gly Cys Cys Tyr Ala Val Lys Arg Ile Pro Ile Asn 
    610                 615                 620                 


Pro Ala Ser Arg Gln Phe Arg Arg Ile Lys Gly Glu Val Thr Leu Leu 
625                 630                 635                 640 


Ser Arg Leu His His Glu Asn Ile Val Arg Tyr Tyr Asn Ala Trp Ile 
                645                 650                 655     


Glu Arg His Glu Arg Pro Ala Gly Pro Gly Thr Pro Pro Pro Asp Ser 
            660                 665                 670         


Gly Pro Leu Ala Lys Asp Asp Arg Ala Ala Arg Gly Gln Pro Ala Ser 
        675                 680                 685             


Asp Thr Asp Gly Leu Asp Ser Val Glu Ala Ala Ala Pro Pro Pro Ile 
    690                 695                 700                 


Leu Ser Ser Ser Val Glu Trp Ser Thr Ser Gly Glu Arg Ser Ala Ser 
705                 710                 715                 720 


Ala Arg Phe Pro Ala Thr Gly Pro Gly Ser Ser Asp Asp Glu Asp Asp 
                725                 730                 735     


Asp Glu Asp Glu His Gly Gly Val Phe Ser Gln Ser Phe Leu Pro Ala 
            740                 745                 750         


Ser Asp Ser Glu Ser Asp Ile Ile Phe Asp Asn Glu Asp Glu Asn Ser 
        755                 760                 765             


Lys Ser Gln Asn Gln Asp Glu Asp Cys Asn Glu Lys Asn Gly Cys His 
    770                 775                 780                 


Glu Ser Glu Pro Ser Val Thr Thr Glu Ala Val His Tyr Leu Tyr Ile 
785                 790                 795                 800 


Gln Met Glu Tyr Cys Glu Lys Ser Thr Leu Arg Asp Thr Ile Asp Gln 
                805                 810                 815     


Gly Leu Tyr Arg Asp Thr Val Arg Leu Trp Arg Leu Phe Arg Glu Ile 
            820                 825                 830         


Leu Asp Gly Leu Ala Tyr Ile His Glu Lys Gly Met Ile His Arg Asp 
        835                 840                 845             


Leu Lys Pro Val Asn Ile Phe Leu Asp Ser Asp Asp His Val Lys Ile 
    850                 855                 860                 


Gly Asp Phe Gly Leu Ala Thr Asp His Leu Ala Phe Ser Ala Asp Ser 
865                 870                 875                 880 


Lys Gln Asp Asp Gln Thr Gly Asp Leu Ile Lys Ser Asp Pro Ser Gly 
                885                 890                 895     


His Leu Thr Gly Met Val Gly Thr Ala Leu Tyr Val Ser Pro Glu Val 
            900                 905                 910         


Gln Gly Ser Thr Lys Ser Ala Tyr Asn Gln Lys Val Asp Leu Phe Ser 
        915                 920                 925             


Leu Gly Ile Ile Phe Phe Glu Met Ser Tyr His Pro Met Val Thr Ala 
    930                 935                 940                 


Ser Glu Arg Ile Phe Val Leu Asn Gln Leu Arg Asp Pro Thr Ser Pro 
945                 950                 955                 960 


Lys Phe Pro Glu Asp Phe Asp Asp Gly Glu His Ala Lys Gln Lys Ser 
                965                 970                 975     


Val Ile Ser Trp Leu Leu Asn His Asp Pro Ala Lys Arg Pro Thr Ala 
            980                 985                 990         


Thr Glu Leu Leu Lys Ser Glu Leu  Leu Pro Pro Pro Gln  Met Glu Glu 
        995                 1000                 1005             


Ser Glu  Leu His Glu Val Leu  His His Thr Leu Thr  Asn Val Asp 
    1010                 1015                 1020             


Gly Lys  Ala Tyr Arg Thr Met  Met Ala Gln Ile Phe  Ser Gln Arg 
    1025                 1030                 1035             


Ile Ser  Pro Ala Ile Asp Tyr  Thr Tyr Asp Ser Asp  Ile Leu Lys 
    1040                 1045                 1050             


Gly Asn  Phe Ser Ile Arg Thr  Ala Lys Met Gln Gln  His Val Cys 
    1055                 1060                 1065             


Glu Thr  Ile Ile Arg Ile Phe  Lys Arg His Gly Ala  Val Gln Leu 
    1070                 1075                 1080             


Cys Thr  Pro Leu Leu Leu Pro  Arg Asn Arg Gln Ile  Tyr Glu His 
    1085                 1090                 1095             


Asn Glu  Ala Ala Leu Phe Met  Asp His Ser Gly Met  Leu Val Met 
    1100                 1105                 1110             


Leu Pro  Phe Asp Leu Arg Ile  Pro Phe Ala Arg Tyr  Val Ala Arg 
    1115                 1120                 1125             


Asn Asn  Ile Leu Asn Leu Lys  Arg Tyr Cys Ile Glu  Arg Val Phe 
    1130                 1135                 1140             


Arg Pro  Arg Lys Leu Asp Arg  Phe His Pro Lys Glu  Leu Leu Glu 
    1145                 1150                 1155             


Cys Ala  Phe Asp Ile Val Thr  Ser Thr Thr Asn Ser  Phe Leu Pro 
    1160                 1165                 1170             


Thr Ala  Glu Ile Ile Tyr Thr  Ile Tyr Glu Ile Ile  Gln Glu Phe 
    1175                 1180                 1185             


Pro Ala  Leu Gln Glu Arg Asn  Tyr Ser Ile Tyr Leu  Asn His Thr 
    1190                 1195                 1200             


Met Leu  Leu Lys Ala Ile Leu  Leu His Cys Gly Ile  Pro Glu Asp 
    1205                 1210                 1215             


Lys Leu  Ser Gln Val Tyr Ile  Ile Leu Tyr Asp Ala  Val Thr Glu 
    1220                 1225                 1230             


Lys Leu  Thr Arg Arg Glu Val  Glu Ala Lys Phe Cys  Asn Leu Ser 
    1235                 1240                 1245             


Leu Ser  Ser Asn Ser Leu Cys  Arg Leu Tyr Lys Phe  Ile Glu Gln 
    1250                 1255                 1260             


Lys Gly  Asp Leu Gln Asp Leu  Met Pro Thr Ile Asn  Ser Leu Ile 
    1265                 1270                 1275             


Lys Gln  Lys Thr Gly Ile Ala  Gln Leu Val Lys Tyr  Gly Leu Lys 
    1280                 1285                 1290             


Asp Leu  Glu Glu Val Val Gly  Leu Leu Lys Lys Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Gln  Val Leu Ile Asn Leu  Gly Leu Val Tyr Lys  Val Gln Gln 
    1310                 1315                 1320             


His Asn  Gly Ile Ile Phe Gln  Phe Val Ala Phe Ile  Lys Arg Arg 
    1325                 1330                 1335             


Gln Arg  Ala Val Pro Glu Ile  Leu Ala Ala Gly Gly  Arg Tyr Asp 
    1340                 1345                 1350             


Leu Leu  Ile Pro Gln Phe Arg  Gly Pro Gln Ala Leu  Gly Pro Val 
    1355                 1360                 1365             


Pro Thr  Ala Ile Gly Val Ser  Ile Ala Ile Asp Lys  Ile Ser Ala 
    1370                 1375                 1380             


Ala Val  Leu Asn Met Glu Glu  Ser Val Thr Ile Ser  Ser Cys Asp 
    1385                 1390                 1395             


Leu Leu  Val Val Ser Val Gly  Gln Met Ser Met Ser  Arg Ala Ile 
    1400                 1405                 1410             


Asn Leu  Thr Gln Lys Leu Trp  Thr Ala Gly Ile Thr  Ala Glu Ile 
    1415                 1420                 1425             


Met Tyr  Asp Trp Ser Gln Ser  Gln Glu Glu Leu Gln  Glu Tyr Cys 
    1430                 1435                 1440             


Arg His  His Glu Ile Thr Tyr  Val Ala Leu Val Ser  Asp Lys Glu 
    1445                 1450                 1455             


Gly Ser  His Val Lys Val Lys  Ser Phe Glu Lys Glu  Arg Gln Thr 
    1460                 1465                 1470             


Glu Lys  Arg Val Leu Glu Thr  Glu Leu Val Asp His  Val Leu Gln 
    1475                 1480                 1485             


Lys Leu  Arg Thr Lys Val Thr  Asp Glu Arg Asn Gly  Arg Glu Ala 
    1490                 1495                 1500             


Ser Asp  Asn Leu Ala Val Gln  Asn Leu Lys Gly Ser  Phe Ser Asn 
    1505                 1510                 1515             


Ala Ser  Gly Leu Phe Glu Ile  His Gly Ala Thr Val  Val Pro Ile 
    1520                 1525                 1530             


Val Ser  Val Leu Ala Pro Glu  Lys Leu Ser Ala Ser  Thr Arg Arg 
    1535                 1540                 1545             


Arg Tyr  Glu Thr Gln Val Gln  Thr Arg Leu Gln Thr  Ser Leu Ala 
    1550                 1555                 1560             


Asn Leu  His Gln Lys Ser Ser  Glu Ile Glu Ile Leu  Ala Val Asp 
    1565                 1570                 1575             


Leu Pro  Lys Glu Thr Ile Leu  Gln Phe Leu Ser Leu  Glu Trp Asp 
    1580                 1585                 1590             


Ala Asp  Glu Gln Ala Phe Asn  Thr Thr Val Lys Gln  Leu Leu Ser 
    1595                 1600                 1605             


Arg Leu  Pro Lys Gln Arg Tyr  Leu Lys Leu Val Cys  Asp Glu Ile 
    1610                 1615                 1620             


Tyr Asn  Ile Lys Val Glu Lys  Lys Val Ser Val Leu  Phe Leu Tyr 
    1625                 1630                 1635             


Ser Tyr  Arg Asp Asp Tyr Tyr  Arg Ile Leu Phe 
    1640                 1645                 


<210> 4940
<211> 1883
<212> PRT
<213> Homo sapiens

<400> 4940
Met Pro Val Gly Arg Ile Glu Cys Pro Ser Ser Pro Ser Phe Pro Arg 
1               5                   10                  15      


Asp Ile Ser His Glu Cys Arg Val Cys Gly Val Thr Glu Val Gly Leu 
            20                  25                  30          


Ser Ala Tyr Ala Lys His Ile Ser Gly Gln Leu His Lys Asp Asn Val 
        35                  40                  45              


Asp Ala Gln Glu Arg Glu Asp Asp Gly Lys Gly Glu Glu Glu Glu Glu 
    50                  55                  60                  


Asp Tyr Phe Asp Lys Glu Leu Ile Gln Leu Ile Lys Gln Arg Lys Glu 
65                  70                  75                  80  


Gln Ser Arg Gln Asp Glu Pro Ser Asn Ser Asn Gln Glu Ile Asn Ser 
                85                  90                  95      


Asp Asp Arg Arg Pro Gln Trp Arg Arg Glu Asp Arg Ile Pro Tyr Gln 
            100                 105                 110         


Asp Arg Glu Ser Tyr Ser Gln Pro Ala Trp His His Arg Gly Pro Pro 
        115                 120                 125             


Gln Arg Asp Trp Lys Trp Glu Lys Asp Gly Phe Asn Asn Thr Arg Lys 
    130                 135                 140                 


Asn Ser Phe Pro His Ser Leu Arg Asn Gly Gly Gly Pro Arg Gly Arg 
145                 150                 155                 160 


Ser Gly Trp His Lys Gly Val Ala Gly Gly Ser Ser Thr Trp Phe His 
                165                 170                 175     


Asn His Ser Asn Ser Gly Gly Gly Trp Leu Ser Asn Ser Gly Ala Val 
            180                 185                 190         


Asp Trp Asn His Asn Gly Thr Gly Arg Asn Ser Ser Trp Leu Ser Glu 
        195                 200                 205             


Gly Thr Gly Gly Phe Ser Ser Trp His Met Asn Asn Ser Asn Gly Asn 
    210                 215                 220                 


Trp Lys Ser Ser Val Arg Ser Thr Asn Asn Trp Asn Tyr Ser Gly Pro 
225                 230                 235                 240 


Gly Asp Lys Phe Gln Pro Gly Arg Asn Arg Asn Ser Asn Cys Gln Met 
                245                 250                 255     


Glu Asp Met Thr Met Leu Trp Asn Lys Lys Ser Asn Lys Ser Asn Lys 
            260                 265                 270         


Tyr Ser His Asp Arg Tyr Asn Trp Gln Arg Gln Glu Asn Asp Lys Leu 
        275                 280                 285             


Gly Thr Val Ala Thr Tyr Arg Gly Pro Ser Glu Gly Phe Thr Ser Asp 
    290                 295                 300                 


Lys Phe Pro Ser Glu Gly Leu Leu Asp Phe Asn Phe Glu Gln Leu Glu 
305                 310                 315                 320 


Ser Gln Thr Thr Lys Gln Ala Asp Thr Ala Thr Ser Lys Val Ser Gly 
                325                 330                 335     


Lys Asn Gly Ser Ala Ala Arg Glu Lys Pro Arg Arg Trp Thr Pro Tyr 
            340                 345                 350         


Pro Ser Gln Lys Thr Leu Asp Leu Gln Ser Gly Leu Lys Asp Ile Thr 
        355                 360                 365             


Gly Asn Lys Ser Glu Met Ile Glu Lys Pro Leu Phe Asp Phe Ser Leu 
    370                 375                 380                 


Ile Thr Thr Gly Ile Gln Glu Pro Gln Thr Asp Glu Thr Arg Asn Ser 
385                 390                 395                 400 


Pro Thr Gln Lys Thr Gln Lys Glu Ile His Thr Gly Ser Leu Asn His 
                405                 410                 415     


Lys Ala Ser Ser Asp Ser Ala Ala Ser Phe Glu Val Val Arg Gln Cys 
            420                 425                 430         


Pro Thr Ala Glu Lys Pro Glu Gln Glu His Thr Pro Asn Lys Met Pro 
        435                 440                 445             


Ser Leu Lys Ser Pro Leu Leu Pro Cys Pro Ala Thr Lys Ser Leu Ser 
    450                 455                 460                 


Gln Lys Gln Asp Pro Lys Asn Ile Ser Lys Asn Thr Lys Thr Asn Phe 
465                 470                 475                 480 


Phe Ser Pro Gly Glu His Ser Asn Pro Ser Asn Lys Pro Thr Val Glu 
                485                 490                 495     


Asp Asn His Gly Pro Tyr Ile Ser Lys Leu Arg Ser Ser Cys Pro His 
            500                 505                 510         


Val Leu Lys Gly Asn Lys Ser Thr Phe Gly Ser Gln Lys Gln Ser Gly 
        515                 520                 525             


Asp Asn Leu Asn Asp Thr Leu Arg Lys Ala Lys Glu Val Leu Gln Cys 
    530                 535                 540                 


His Glu Ser Leu Gln Asn Pro Leu Leu Ser Thr Ser Lys Ser Thr Arg 
545                 550                 555                 560 


Asn Tyr Ala Lys Ala Ser Arg Asn Val Glu Glu Ser Glu Lys Gly Ser 
                565                 570                 575     


Leu Lys Ile Glu Phe Gln Val His Ala Leu Glu Asp Glu Ser Asp Gly 
            580                 585                 590         


Glu Thr Ser Asp Thr Glu Lys His Gly Thr Lys Ile Gly Thr Leu Gly 
        595                 600                 605             


Ser Ala Thr Thr Glu Leu Leu Ser Gly Ser Thr Arg Thr Ala Asp Glu 
    610                 615                 620                 


Lys Glu Glu Asp Asp Arg Ile Leu Lys Thr Ser Arg Glu Leu Ser Thr 
625                 630                 635                 640 


Ser Pro Cys Asn Pro Ile Val Arg Gln Lys Glu Ser Glu Leu Gln Met 
                645                 650                 655     


Thr Ser Ala Ala Ser Pro His Pro Gly Leu Leu Leu Asp Leu Lys Thr 
            660                 665                 670         


Ser Leu Glu Asp Ala Gln Val Asp Asp Ser Ile Lys Ser His Val Ser 
        675                 680                 685             


Tyr Glu Thr Glu Gly Phe Glu Ser Ala Ser Leu Asp Ala Glu Leu Gln 
    690                 695                 700                 


Lys Ser Asp Ile Ser Gln Pro Ser Gly Pro Leu Leu Pro Glu Leu Ser 
705                 710                 715                 720 


Lys Leu Gly Phe Pro Ala Ser Leu Gln Arg Asp Leu Thr Arg His Ile 
                725                 730                 735     


Ser Leu Lys Ser Lys Thr Gly Val His Leu Pro Glu Pro Asn Leu Asn 
            740                 745                 750         


Ser Ala Arg Arg Ile Arg Asn Ile Ser Gly His Arg Lys Ser Glu Thr 
        755                 760                 765             


Glu Lys Glu Ser Gly Leu Lys Pro Thr Leu Arg Gln Ile Leu Asn Ala 
    770                 775                 780                 


Ser Arg Arg Asn Val Asn Trp Glu Gln Val Ile Gln Gln Val Thr Lys 
785                 790                 795                 800 


Lys Lys Gln Glu Leu Gly Lys Gly Leu Pro Arg Phe Gly Ile Glu Met 
                805                 810                 815     


Val Pro Leu Val Gln Asn Glu Gln Glu Ala Leu Asp Leu Asp Gly Glu 
            820                 825                 830         


Pro Asp Leu Ser Ser Leu Glu Gly Phe Gln Trp Glu Gly Val Ser Ile 
        835                 840                 845             


Ser Ser Ser Pro Gly Leu Ala Arg Lys Arg Ser Leu Ser Glu Ser Ser 
    850                 855                 860                 


Val Ile Met Asp Arg Ala Pro Ser Val Tyr Ser Phe Phe Ser Glu Glu 
865                 870                 875                 880 


Gly Thr Gly Lys Glu Asn Glu Pro Gln Gln Met Val Ser Pro Ser Asn 
                885                 890                 895     


Ser Leu Arg Ala Gly Gln Ser Gln Lys Ala Thr Met His Leu Lys Gln 
            900                 905                 910         


Glu Val Thr Pro Arg Ala Ala Ser Leu Arg Thr Gly Glu Arg Ala Glu 
        915                 920                 925             


Asn Val Ala Thr Gln Arg Arg His Ser Ala Gln Leu Ser Ser Asp His 
    930                 935                 940                 


Ile Ile Pro Leu Met His Leu Ala Lys Asp Leu Asn Ser Gln Glu Arg 
945                 950                 955                 960 


Ser Ile Pro Pro Ser Glu Asn Gln Asn Ser Gln Glu Ser Asn Gly Glu 
                965                 970                 975     


Gly Asn Cys Leu Ser Ser Ser Ala Ser Ser Ala Leu Ala Ile Ser Ser 
            980                 985                 990         


Leu Ala Asp Ala Ala Thr Asp Ser  Ser Cys Thr Ser Gly  Ala Glu Gln 
        995                 1000                 1005             


Asn Asp  Gly Gln Ser Ile Arg  Lys Lys Arg Arg Ala  Thr Gly Asp 
    1010                 1015                 1020             


Gly Ser  Ser Pro Glu Leu Pro  Ser Leu Glu Arg Lys  Asn Lys Arg 
    1025                 1030                 1035             


Arg Lys  Ile Lys Gly Lys Lys  Glu Arg Ser Gln Val  Asp Gln Leu 
    1040                 1045                 1050             


Leu Asn  Ile Ser Leu Arg Glu  Glu Glu Leu Ser Lys  Ser Leu Gln 
    1055                 1060                 1065             


Cys Met  Asp Asn Asn Leu Leu  Gln Ala Arg Ala Ala  Leu Gln Thr 
    1070                 1075                 1080             


Ala Tyr  Val Glu Val Gln Arg  Leu Leu Met Leu Lys  Gln Gln Ile 
    1085                 1090                 1095             


Thr Met  Glu Met Ser Ala Leu  Arg Thr His Arg Ile  Gln Ile Leu 
    1100                 1105                 1110             


Gln Gly  Leu Gln Glu Thr Tyr  Glu Pro Ser Glu His  Pro Asp Gln 
    1115                 1120                 1125             


Val Pro  Cys Ser Leu Thr Arg  Glu Arg Arg Asn Ser  Arg Ser Gln 
    1130                 1135                 1140             


Thr Ser  Ile Asp Ala Ala Leu  Leu Pro Thr Pro Phe  Phe Pro Leu 
    1145                 1150                 1155             


Phe Leu  Glu Pro Pro Ser Ser  His Val Ser Pro Ser  Pro Thr Gly 
    1160                 1165                 1170             


Ala Ser  Leu Gln Ile Thr Thr  Ser Pro Thr Phe Gln  Thr His Gly 
    1175                 1180                 1185             


Ser Val  Pro Ala Pro Asp Ser  Ser Val Gln Ile Lys  Gln Glu Pro 
    1190                 1195                 1200             


Met Ser  Pro Glu Gln Asp Glu  Asn Val Asn Ala Val  Pro Pro Ser 
    1205                 1210                 1215             


Ser Ala  Cys Asn Val Ser Lys  Glu Leu Leu Glu Ala  Asn Arg Glu 
    1220                 1225                 1230             


Ile Ser  Asp Ser Cys Pro Val  Tyr Pro Val Ile Thr  Ala Arg Leu 
    1235                 1240                 1245             


Ser Leu  Pro Glu Ser Thr Glu  Ser Phe His Glu Pro  Ser Gln Glu 
    1250                 1255                 1260             


Leu Lys  Phe Ser Val Glu Gln  Arg Asn Thr Arg Asn  Arg Glu Asn 
    1265                 1270                 1275             


Ser Pro  Ser Ser Gln Ser Ala  Gly Leu Ser Ser Ile  Asn Lys Glu 
    1280                 1285                 1290             


Gly Glu  Glu Pro Thr Lys Gly  Asn Ser Gly Ser Glu  Ala Cys Thr 
    1295                 1300                 1305             


Ser Ser  Phe Leu Arg Leu Ser  Phe Ala Ser Glu Thr  Pro Leu Glu 
    1310                 1315                 1320             


Lys Glu  Pro His Ser Pro Ala  Asp Gln Pro Glu Gln  Gln Ala Glu 
    1325                 1330                 1335             


Ser Thr  Leu Thr Ser Ala Glu  Thr Arg Gly Ser Lys  Lys Lys Lys 
    1340                 1345                 1350             


Lys Leu  Arg Lys Lys Lys Ser  Leu Arg Ala Ala His  Val Pro Glu 
    1355                 1360                 1365             


Asn Ser  Asp Thr Glu Gln Asp  Val Leu Thr Val Lys  Pro Val Arg 
    1370                 1375                 1380             


Lys Val  Lys Ala Gly Lys Leu  Ile Lys Gly Gly Lys  Val Thr Thr 
    1385                 1390                 1395             


Ser Thr  Trp Glu Asp Ser Arg  Thr Gly Arg Glu Gln  Glu Ser Val 
    1400                 1405                 1410             


Arg Asp  Glu Pro Asp Ser Asp  Ser Ser Leu Glu Val  Leu Glu Ile 
    1415                 1420                 1425             


Pro Asn  Pro Gln Leu Glu Val  Val Ala Ile Asp Ser  Ser Glu Ser 
    1430                 1435                 1440             


Gly Glu  Glu Lys Pro Asp Ser  Pro Ser Lys Lys Asp  Ile Trp Asn 
    1445                 1450                 1455             


Ser Thr  Glu Gln Asn Pro Leu  Glu Thr Ser Arg Ser  Gly Cys Asp 
    1460                 1465                 1470             


Glu Val  Ser Ser Thr Ser Glu  Ile Gly Thr Arg Tyr  Lys Asp Gly 
    1475                 1480                 1485             


Ile Pro  Val Ser Val Ala Glu  Thr Gln Thr Val Ile  Ser Ser Ile 
    1490                 1495                 1500             


Lys Gly  Ser Lys Asn Ser Ser  Glu Ile Ser Ser Glu  Pro Gly Asp 
    1505                 1510                 1515             


Asp Asp  Glu Pro Thr Glu Gly  Ser Phe Glu Gly His  Gln Ala Ala 
    1520                 1525                 1530             


Val Asn  Ala Ile Gln Ile Phe  Gly Asn Leu Leu Tyr  Thr Cys Ser 
    1535                 1540                 1545             


Ala Asp  Lys Thr Val Arg Val  Tyr Asn Leu Val Ser  Arg Lys Cys 
    1550                 1555                 1560             


Ile Gly  Val Phe Glu Gly His  Thr Ser Lys Val Asn  Cys Leu Leu 
    1565                 1570                 1575             


Val Thr  Gln Thr Ser Gly Lys  Asn Ala Ala Leu Tyr  Thr Gly Ser 
    1580                 1585                 1590             


Ser Asp  His Thr Ile Arg Cys  Tyr Asn Val Lys Ser  Arg Glu Cys 
    1595                 1600                 1605             


Val Glu  Gln Leu Gln Leu Glu  Asp Arg Val Leu Cys  Leu His Ser 
    1610                 1615                 1620             


Arg Trp  Arg Ile Leu Tyr Ala  Gly Leu Ala Asn Gly  Thr Val Val 
    1625                 1630                 1635             


Thr Phe  Asn Ile Lys Asn Asn  Lys Arg Leu Glu Ile  Phe Glu Cys 
    1640                 1645                 1650             


His Gly  Pro Arg Ala Val Ser  Cys Leu Ala Thr Ala  Gln Glu Gly 
    1655                 1660                 1665             


Ala Arg  Lys Leu Leu Val Val  Gly Ser Tyr Asp Cys  Thr Ile Ser 
    1670                 1675                 1680             


Val Arg  Asp Ala Arg Asn Gly  Leu Leu Leu Arg Thr  Leu Glu Gly 
    1685                 1690                 1695             


His Ser  Lys Thr Ile Leu Cys  Met Lys Val Val Asn  Asp Leu Val 
    1700                 1705                 1710             


Phe Ser  Gly Ser Ser Asp Gln  Ser Val His Ala His  Asn Ile His 
    1715                 1720                 1725             


Thr Gly  Glu Leu Val Arg Ile  Tyr Lys Gly His Asn  His Ala Val 
    1730                 1735                 1740             


Thr Val  Val Asn Ile Leu Gly  Lys Val Met Val Thr  Ala Cys Leu 
    1745                 1750                 1755             


Asp Lys  Phe Val Arg Val Tyr  Glu Leu Gln Ser His  Asp Arg Leu 
    1760                 1765                 1770             


Gln Val  Tyr Gly Gly His Lys  Asp Met Ile Met Cys  Met Thr Ile 
    1775                 1780                 1785             


His Lys  Ser Met Ile Tyr Thr  Gly Cys Tyr Asp Gly  Ser Ile Gln 
    1790                 1795                 1800             


Ala Val  Arg Leu Asn Leu Met  Gln Asn Tyr Arg Cys  Trp Trp His 
    1805                 1810                 1815             


Gly Cys  Ser Leu Ile Phe Gly  Val Val Asp His Leu  Lys Gln His 
    1820                 1825                 1830             


Leu Leu  Thr Asp His Thr Asn  Pro Asn Phe Gln Thr  Leu Lys Cys 
    1835                 1840                 1845             


Arg Trp  Lys Asn Cys Asp Ala  Phe Phe Thr Ala Arg  Lys Gly Ser 
    1850                 1855                 1860             


Lys Gln  Asp Ala Ala Gly His  Ile Glu Arg His Ala  Glu Asp Asp 
    1865                 1870                 1875             


Ser Lys  Ile Asp Ser 
    1880             


<210> 4941
<211> 195
<212> PRT
<213> Homo sapiens

<400> 4941
Met Ala Glu Pro Val Gln Glu Glu Leu Ser Val Leu Ala Ala Ile Phe 
1               5                   10                  15      


Cys Arg Pro His Glu Trp Glu Val Leu Ser Arg Ser Glu Thr Asp Gly 
            20                  25                  30          


Thr Val Phe Arg Ile His Thr Lys Ala Glu Gly Phe Met Asp Val Asp 
        35                  40                  45              


Ile Pro Leu Glu Leu Val Phe His Leu Pro Val Asn Tyr Pro Ser Cys 
    50                  55                  60                  


Leu Pro Gly Ile Ser Ile Asn Ser Glu Gln Leu Thr Arg Ala Gln Cys 
65                  70                  75                  80  


Val Thr Val Lys Glu Asn Leu Leu Glu Gln Ala Glu Ser Leu Leu Ser 
                85                  90                  95      


Glu Pro Met Val His Glu Leu Val Leu Trp Ile Gln Gln Asn Leu Arg 
            100                 105                 110         


His Ile Leu Ser Gln Pro Glu Thr Gly Ser Gly Ser Glu Lys Cys Thr 
        115                 120                 125             


Phe Ser Thr Ser Thr Thr Met Asp Asp Gly Leu Trp Ile Thr Leu Leu 
    130                 135                 140                 


His Leu Asp His Met Arg Ala Lys Thr Lys Tyr Val Lys Ile Val Glu 
145                 150                 155                 160 


Lys Trp Ala Ser Asp Leu Arg Leu Thr Gly Arg Leu Met Phe Met Gly 
                165                 170                 175     


Lys Ile Ile Leu Ile Leu Leu Gln Gly Asp Arg Asn Asn Leu Lys Val 
            180                 185                 190         


Pro Lys Ser 
        195 


<210> 4942
<211> 372
<212> PRT
<213> Homo sapiens

<400> 4942
Met Ser Arg Arg Arg Phe Asp Cys Arg Ser Ile Ser Gly Leu Leu Thr 
1               5                   10                  15      


Thr Thr Pro Gln Ile Pro Ile Lys Met Glu Asn Phe Asn Asn Phe Tyr 
            20                  25                  30          


Ile Leu Thr Ser Lys Glu Leu Gly Arg Gly Lys Phe Ala Val Val Arg 
        35                  40                  45              


Gln Cys Ile Ser Lys Ser Thr Gly Gln Glu Tyr Ala Ala Lys Phe Leu 
    50                  55                  60                  


Lys Lys Arg Arg Arg Gly Gln Asp Cys Arg Ala Glu Ile Leu His Glu 
65                  70                  75                  80  


Ile Ala Val Leu Glu Leu Ala Lys Ser Cys Pro Arg Val Ile Asn Leu 
                85                  90                  95      


His Glu Val Tyr Glu Asn Thr Ser Glu Ile Ile Leu Ile Leu Glu Tyr 
            100                 105                 110         


Ala Ala Gly Gly Glu Ile Phe Ser Leu Cys Leu Pro Glu Leu Ala Glu 
        115                 120                 125             


Met Val Ser Glu Asn Asp Val Ile Arg Leu Ile Lys Gln Ile Leu Glu 
    130                 135                 140                 


Gly Val Tyr Tyr Leu His Gln Asn Asn Ile Val His Leu Asp Leu Lys 
145                 150                 155                 160 


Pro Gln Asn Ile Leu Leu Ser Ser Ile Tyr Pro Leu Gly Asp Ile Lys 
                165                 170                 175     


Ile Val Asp Phe Gly Met Ser Arg Lys Ile Gly His Ala Cys Glu Leu 
            180                 185                 190         


Arg Glu Ile Met Gly Thr Pro Glu Tyr Leu Ala Pro Glu Ile Leu Asn 
        195                 200                 205             


Tyr Asp Pro Ile Thr Thr Ala Thr Asp Met Trp Asn Ile Gly Ile Ile 
    210                 215                 220                 


Ala Tyr Met Leu Leu Thr His Thr Ser Pro Phe Val Gly Glu Asp Asn 
225                 230                 235                 240 


Gln Glu Thr Tyr Leu Asn Ile Ser Gln Val Asn Val Asp Tyr Ser Glu 
                245                 250                 255     


Glu Thr Phe Ser Ser Val Ser Gln Leu Ala Thr Asp Phe Ile Gln Ser 
            260                 265                 270         


Leu Leu Val Lys Asn Pro Glu Lys Arg Pro Thr Ala Glu Ile Cys Leu 
        275                 280                 285             


Ser His Ser Trp Leu Gln Gln Trp Asp Phe Glu Asn Leu Phe His Pro 
    290                 295                 300                 


Glu Glu Thr Ser Ser Ser Ser Gln Thr Gln Asp His Ser Val Arg Ser 
305                 310                 315                 320 


Ser Glu Asp Lys Thr Ser Lys Ser Ser Cys Asn Gly Thr Cys Gly Asp 
                325                 330                 335     


Arg Glu Asp Lys Glu Asn Ile Pro Glu Asp Ser Ser Met Val Ser Lys 
            340                 345                 350         


Arg Phe Arg Phe Asp Asp Ser Leu Pro Asn Pro His Glu Leu Val Ser 
        355                 360                 365             


Asp Leu Leu Cys 
    370         


<210> 4943
<211> 309
<212> PRT
<213> Homo sapiens

<400> 4943
Met Glu Ala Ala Arg Thr Ala Val Leu Arg Val Lys Arg Lys Arg Ser 
1               5                   10                  15      


Ala Glu Pro Ala Glu Ala Leu Val Leu Ala Cys Lys Arg Leu Arg Ser 
            20                  25                  30          


Asp Ala Val Glu Ser Ala Ala Gln Lys Thr Ser Glu Gly Leu Glu Arg 
        35                  40                  45              


Ala Ala Glu Asn Asn Val Phe His Leu Val Ala Thr Val Cys Ser Gln 
    50                  55                  60                  


Glu Glu Pro Val Gln Pro Leu Leu Arg Glu Val Leu Arg Pro Ser Arg 
65                  70                  75                  80  


Asp Ser Gln Gln Arg Val Arg Arg Asn Leu Arg Ala Ser Ala Arg Glu 
                85                  90                  95      


Val Arg Gln Glu Gly Arg Tyr Arg Val Leu Ser Ser Arg Arg Ser Leu 
            100                 105                 110         


Gly Thr Thr Ser Ser Gly Gln Glu Ser Glu Tyr Thr Pro Gly Asn Pro 
        115                 120                 125             


Glu Ala Ala Gly Asn Ser Gly Phe Gln Leu Leu Asp Leu Val His Glu 
    130                 135                 140                 


Glu Gly Glu Pro Glu Ala Ala Ser Ala Gly Ser Cys Lys Thr Ser Asp 
145                 150                 155                 160 


Pro Asp Val Ile Leu Cys Asn Ser Val Glu Leu Ile Arg Glu Arg Leu 
                165                 170                 175     


Thr Val Ser Glu Asp Gly Pro Gly Val Arg Arg Gln Glu Glu Gln Lys 
            180                 185                 190         


His Asp Asp Tyr Val Tyr Asp Ile Tyr Tyr Leu Glu Thr Ala Thr Pro 
        195                 200                 205             


Gly Trp Ile Glu Asn Ile Leu Ser Val Gln Pro Tyr Ser Gln Glu Trp 
    210                 215                 220                 


Glu Leu Val Asn Asp Asp Gln Glu Pro Glu Asp Ile Tyr Asp Asp Glu 
225                 230                 235                 240 


Asp Asp Glu Asn Ser Glu Asn Asn Trp Arg Asn Glu Tyr Pro Glu Glu 
                245                 250                 255     


Glu Ser Ser Asp Gly Asp Glu Asp Ser Arg Gly Ser Ala Asp Tyr Asn 
            260                 265                 270         


Ser Leu Ser Glu Glu Glu Arg Gly Ser Ser Arg Gln Arg Met Trp Ser 
        275                 280                 285             


Lys Tyr Pro Leu Asp Val Gln Lys Glu Phe Gly Tyr Asp Ser Pro His 
    290                 295                 300                 


Asp Leu Asp Ser Asp 
305                 


<210> 4944
<211> 355
<212> PRT
<213> Homo sapiens

<400> 4944
Met Ala Asp Asn Ser Ser Asp Glu Cys Glu Glu Glu Asn Asn Lys Val 
1               5                   10                  15      


Leu Arg Glu Gly Met Pro Gln Ala Pro Gly His Arg Gly Lys Asp Met 
            20                  25                  30          


Asp Pro Val Pro Pro Ala Pro Ala Ser Leu Lys Cys His Gln Thr Pro 
        35                  40                  45              


Ser His Val Leu Glu Arg Val Gly Trp Tyr Arg Glu Ser Gln Lys His 
    50                  55                  60                  


Arg Lys Glu Lys Lys Lys Thr Ser Gln Leu Thr Pro Gln Arg Gly Phe 
65                  70                  75                  80  


Ser Glu Asn Glu Asp Asp Asp Asp Asp Asp Asp Asp Ser Ser Glu Thr 
                85                  90                  95      


Asp Ser Asp Ser Asp Asp Asp Asp Glu Glu His Gly Ala Pro Leu Glu 
            100                 105                 110         


Gly Ala Tyr Asp Pro Ala Asp Tyr Glu His Leu Pro Val Ser Ala Glu 
        115                 120                 125             


Ile Lys Glu Leu Phe Gln Tyr Ile Ser Arg Tyr Thr Pro Gln Leu Ile 
    130                 135                 140                 


Asp Leu Asp His Lys Leu Lys Pro Phe Ile Pro Asp Phe Ile Pro Ala 
145                 150                 155                 160 


Val Gly Asp Ile Asp Ala Phe Leu Lys Val Pro Arg Pro Asp Gly Lys 
                165                 170                 175     


Pro Asp Asn Leu Gly Leu Leu Val Leu Asp Glu Pro Ser Thr Lys Gln 
            180                 185                 190         


Ser Asp Pro Thr Val Leu Ser Leu Trp Leu Thr Glu Asn Ser Lys Gln 
        195                 200                 205             


His Asn Ile Thr Gln His Met Lys Val Lys Ser Leu Glu Asp Ala Glu 
    210                 215                 220                 


Lys Asn Pro Lys Ala Ile Asp Thr Trp Ile Glu Ser Ile Ser Glu Leu 
225                 230                 235                 240 


His Arg Ser Lys Pro Pro Ala Thr Val His Tyr Thr Arg Pro Met Pro 
                245                 250                 255     


Asp Ile Asp Thr Leu Met Gln Glu Trp Ser Pro Glu Phe Glu Glu Leu 
            260                 265                 270         


Leu Gly Lys Val Ser Leu Pro Thr Ala Glu Ile Asp Cys Ser Leu Ala 
        275                 280                 285             


Glu Tyr Ile Asp Met Ile Cys Ala Ile Leu Asp Ile Pro Val Tyr Lys 
    290                 295                 300                 


Ser Arg Ile Gln Ser Leu His Leu Leu Phe Ser Leu Tyr Ser Glu Phe 
305                 310                 315                 320 


Lys Asn Ser Gln His Phe Lys Ala Leu Ala Glu Gly Lys Lys Ala Phe 
                325                 330                 335     


Thr Pro Ser Ser Asn Ser Thr Ser Gln Ala Gly Asp Met Glu Thr Leu 
            340                 345                 350         


Thr Phe Ser 
        355 


<210> 4945
<211> 304
<212> PRT
<213> Homo sapiens

<400> 4945
Met Ala Asp Asn Ser Ser Asp Glu Cys Glu Glu Glu Asn Asn Lys Glu 
1               5                   10                  15      


Lys Lys Lys Thr Ser Gln Leu Thr Pro Gln Arg Gly Phe Ser Glu Asn 
            20                  25                  30          


Glu Asp Asp Asp Asp Asp Asp Asp Asp Ser Ser Glu Thr Asp Ser Asp 
        35                  40                  45              


Ser Asp Asp Asp Asp Glu Glu His Gly Ala Pro Leu Glu Gly Ala Tyr 
    50                  55                  60                  


Asp Pro Ala Asp Tyr Glu His Leu Pro Val Ser Ala Glu Ile Lys Glu 
65                  70                  75                  80  


Leu Phe Gln Tyr Ile Ser Arg Tyr Thr Pro Gln Leu Ile Asp Leu Asp 
                85                  90                  95      


His Lys Leu Lys Pro Phe Ile Pro Asp Phe Ile Pro Ala Val Gly Asp 
            100                 105                 110         


Ile Asp Ala Phe Leu Lys Val Pro Arg Pro Asp Gly Lys Pro Asp Asn 
        115                 120                 125             


Leu Gly Leu Leu Val Leu Asp Glu Pro Ser Thr Lys Gln Ser Asp Pro 
    130                 135                 140                 


Thr Val Leu Ser Leu Trp Leu Thr Glu Asn Ser Lys Gln His Asn Ile 
145                 150                 155                 160 


Thr Gln His Met Lys Val Lys Ser Leu Glu Asp Ala Glu Lys Asn Pro 
                165                 170                 175     


Lys Ala Ile Asp Thr Trp Ile Glu Ser Ile Ser Glu Leu His Arg Ser 
            180                 185                 190         


Lys Pro Pro Ala Thr Val His Tyr Thr Arg Pro Met Pro Asp Ile Asp 
        195                 200                 205             


Thr Leu Met Gln Glu Trp Ser Pro Glu Phe Glu Glu Leu Leu Gly Lys 
    210                 215                 220                 


Val Ser Leu Pro Thr Ala Glu Ile Asp Cys Ser Leu Ala Glu Tyr Ile 
225                 230                 235                 240 


Asp Met Ile Cys Ala Ile Leu Asp Ile Pro Val Tyr Lys Ser Arg Ile 
                245                 250                 255     


Gln Ser Leu His Leu Leu Phe Ser Leu Tyr Ser Glu Phe Lys Asn Ser 
            260                 265                 270         


Gln His Phe Lys Ala Leu Ala Glu Gly Lys Lys Ala Phe Thr Pro Ser 
        275                 280                 285             


Ser Asn Ser Thr Ser Gln Ala Gly Asp Met Glu Thr Leu Thr Phe Ser 
    290                 295                 300                 


<210> 4946
<211> 444
<212> PRT
<213> Homo sapiens

<400> 4946
Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Asn Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Phe Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ser Val Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 


<210> 4947
<211> 465
<212> PRT
<213> Homo sapiens

<400> 4947
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly 
    290                 295                 300                 


Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu 
305                 310                 315                 320 


Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile 
                325                 330                 335     


Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Ala 
            340                 345                 350         


Thr Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu 
        355                 360                 365             


Glu Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys 
    370                 375                 380                 


Lys Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly 
385                 390                 395                 400 


Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln 
                405                 410                 415     


Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly 
            420                 425                 430         


Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr 
        435                 440                 445             


Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys 
    450                 455                 460                 


Asn 
465 


<210> 4948
<211> 1585
<212> PRT
<213> Homo sapiens

<400> 4948
Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Phe Gln Arg Pro Gln 
1               5                   10                  15      


Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg 
            20                  25                  30          


Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile 
        35                  40                  45              


Met Met Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro 
    50                  55                  60                  


Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly 
65                  70                  75                  80  


Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr 
                85                  90                  95      


Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe 
            100                 105                 110         


Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr 
        115                 120                 125             


Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile 
    130                 135                 140                 


Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser 
                165                 170                 175     


Thr Pro Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser 
            180                 185                 190         


Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr 
        195                 200                 205             


Pro Val Thr Ala Ala Ser Asp Gln Lys Gln Glu Glu Lys Pro Lys Pro 
    210                 215                 220                 


Asp Pro Val Leu Lys Ser Pro Ser Pro Val Leu Arg Leu Val Leu Ser 
225                 230                 235                 240 


Gly Glu Lys Lys Glu Gln Glu Gly Gln Thr Ser Glu Thr Thr Ala Ile 
                245                 250                 255     


Val Ser Ile Ala Glu Leu Pro Leu Pro Pro Ser Pro Thr Thr Val Ser 
            260                 265                 270         


Ser Val Ala Arg Ser Thr Ile Ala Ala Pro Thr Ser Ser Ala Leu Ser 
        275                 280                 285             


Ser Gln Pro Ile Phe Thr Thr Ala Ile Asp Asp Arg Cys Glu Leu Ser 
    290                 295                 300                 


Ser Pro Arg Glu Asp Thr Ile Pro Ile Pro Ser Leu Thr Ser Cys Thr 
305                 310                 315                 320 


Glu Thr Ser Asp Pro Leu Pro Thr Asn Glu Asn Asp Asp Asp Ile Cys 
                325                 330                 335     


Lys Lys Pro Cys Ser Val Ala Pro Asn Asp Ile Pro Leu Val Ser Ser 
            340                 345                 350         


Thr Asn Leu Ile Asn Glu Ile Asn Gly Val Ser Glu Lys Leu Ser Ala 
        355                 360                 365             


Thr Glu Ser Ile Val Glu Ile Val Lys Gln Glu Val Leu Pro Leu Thr 
    370                 375                 380                 


Leu Glu Leu Glu Ile Leu Glu Asn Pro Pro Glu Glu Met Lys Leu Glu 
385                 390                 395                 400 


Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr Val Pro Ser Phe Pro Pro 
                405                 410                 415     


Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro His Thr Pro Val Ile Val 
            420                 425                 430         


Pro Ala Ala Ala Thr Thr Val Ser Ser Pro Ser Ala Ala Ile Thr Val 
        435                 440                 445             


Gln Arg Val Leu Glu Glu Asp Glu Ser Ile Arg Thr Cys Leu Ser Glu 
    450                 455                 460                 


Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu Val Glu Ala Asp Gly Gln 
465                 470                 475                 480 


Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser Arg Arg Ser Pro 
                485                 490                 495     


Val Pro Ala Gln Ile Ala Ile Thr Val Pro Lys Thr Trp Lys Lys Pro 
            500                 505                 510         


Lys Asp Arg Thr Arg Thr Thr Glu Glu Met Leu Glu Ala Glu Leu Glu 
        515                 520                 525             


Leu Lys Ala Glu Glu Glu Leu Ser Ile Asp Lys Val Leu Glu Ser Glu 
    530                 535                 540                 


Gln Asp Lys Met Ser Gln Gly Phe His Pro Glu Arg Asp Pro Ser Asp 
545                 550                 555                 560 


Leu Lys Lys Val Lys Ala Val Glu Glu Asn Gly Glu Glu Ala Glu Pro 
                565                 570                 575     


Val Arg Asn Gly Ala Glu Ser Val Ser Glu Gly Glu Gly Ile Asp Ala 
            580                 585                 590         


Asn Ser Gly Ser Thr Asp Ser Ser Gly Asp Gly Val Thr Phe Pro Phe 
        595                 600                 605             


Lys Pro Glu Ser Trp Lys Pro Thr Asp Thr Glu Gly Lys Lys Gln Tyr 
    610                 615                 620                 


Asp Arg Glu Phe Leu Leu Asp Phe Gln Phe Met Pro Ala Cys Ile Gln 
625                 630                 635                 640 


Lys Pro Glu Gly Leu Pro Pro Ile Ser Asp Val Val Leu Asp Lys Ile 
                645                 650                 655     


Asn Gln Pro Lys Leu Pro Met Arg Thr Leu Asp Pro Arg Ile Leu Pro 
            660                 665                 670         


Arg Gly Pro Asp Phe Thr Pro Ala Phe Ala Asp Phe Gly Arg Gln Thr 
        675                 680                 685             


Pro Gly Gly Arg Gly Val Pro Leu Leu Asn Val Gly Ser Arg Arg Ser 
    690                 695                 700                 


Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys Ile Ile Thr Val Ser Val 
705                 710                 715                 720 


Lys Glu Asp Val His Leu Lys Lys Ala Glu Asn Ala Trp Lys Pro Ser 
                725                 730                 735     


Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro Glu Asn Ile Lys Thr Gln 
            740                 745                 750         


Glu Leu Phe Arg Lys Val Arg Ser Ile Leu Asn Lys Leu Thr Pro Gln 
        755                 760                 765             


Met Phe Asn Gln Leu Met Lys Gln Val Ser Gly Leu Thr Val Asp Thr 
    770                 775                 780                 


Glu Glu Arg Leu Lys Gly Val Ile Asp Leu Val Phe Glu Lys Ala Ile 
785                 790                 795                 800 


Asp Glu Pro Ser Phe Ser Val Ala Tyr Ala Asn Met Cys Arg Cys Leu 
                805                 810                 815     


Val Thr Leu Lys Val Pro Met Ala Asp Lys Pro Gly Asn Thr Val Asn 
            820                 825                 830         


Phe Arg Lys Leu Leu Leu Asn Arg Cys Gln Lys Glu Phe Glu Lys Asp 
        835                 840                 845             


Lys Ala Asp Asp Asp Val Phe Glu Lys Lys Gln Lys Glu Leu Glu Ala 
    850                 855                 860                 


Ala Ser Ala Pro Glu Glu Arg Thr Arg Leu His Asp Glu Leu Glu Glu 
865                 870                 875                 880 


Ala Lys Asp Lys Ala Arg Arg Arg Ser Ile Gly Asn Ile Lys Phe Ile 
                885                 890                 895     


Gly Glu Leu Phe Lys Leu Lys Met Leu Thr Glu Ala Ile Met His Asp 
            900                 905                 910         


Cys Val Val Lys Leu Leu Lys Asn His Asp Glu Glu Ser Leu Glu Cys 
        915                 920                 925             


Leu Cys Arg Leu Leu Thr Thr Ile Gly Lys Asp Leu Asp Phe Glu Lys 
    930                 935                 940                 


Ala Lys Pro Arg Met Asp Gln Tyr Phe Asn Gln Met Glu Lys Ile Val 
945                 950                 955                 960 


Lys Glu Arg Lys Thr Ser Ser Arg Ile Arg Phe Met Leu Gln Asp Val 
                965                 970                 975     


Ile Asp Leu Arg Leu Cys Asn Trp Val Ser Arg Arg Ala Asp Gln Gly 
            980                 985                 990         


Pro Lys Thr Ile Glu Gln Ile His  Lys Glu Ala Lys Ile  Glu Glu Gln 
        995                 1000                 1005             


Glu Glu  Gln Arg Lys Val Gln  Gln Leu Met Thr Lys  Glu Lys Arg 
    1010                 1015                 1020             


Arg Pro  Gly Val Gln Arg Val  Asp Glu Gly Gly Trp  Asn Thr Val 
    1025                 1030                 1035             


Gln Gly  Ala Lys Asn Ser Arg  Val Leu Asp Pro Ser  Lys Phe Leu 
    1040                 1045                 1050             


Lys Ile  Thr Lys Pro Thr Ile  Asp Glu Lys Ile Gln  Leu Val Pro 
    1055                 1060                 1065             


Lys Ala  Gln Leu Gly Ser Trp  Gly Lys Gly Ser Ser  Gly Gly Ala 
    1070                 1075                 1080             


Lys Ala  Ser Glu Thr Asp Ala  Leu Arg Ser Ser Ala  Ser Ser Leu 
    1085                 1090                 1095             


Asn Arg  Phe Ser Ala Leu Gln  Pro Pro Ala Pro Ser  Gly Ser Thr 
    1100                 1105                 1110             


Pro Ser  Thr Pro Val Glu Phe  Asp Ser Arg Arg Thr  Leu Thr Ser 
    1115                 1120                 1125             


Arg Gly  Ser Met Gly Arg Glu  Lys Asn Asp Lys Pro  Leu Pro Ser 
    1130                 1135                 1140             


Ala Thr  Ala Arg Pro Asn Thr  Phe Met Arg Gly Gly  Ser Ser Lys 
    1145                 1150                 1155             


Asp Leu  Leu Asp Asn Gln Ser  Gln Glu Glu Gln Arg  Arg Glu Met 
    1160                 1165                 1170             


Leu Glu  Thr Val Lys Gln Leu  Thr Gly Gly Val Asp  Val Glu Arg 
    1175                 1180                 1185             


Asn Ser  Thr Glu Ala Glu Arg  Asn Lys Thr Arg Glu  Ser Ala Lys 
    1190                 1195                 1200             


Pro Glu  Ile Ser Ala Met Ser  Ala His Asp Lys Ala  Ala Leu Ser 
    1205                 1210                 1215             


Glu Glu  Glu Leu Glu Arg Lys  Ser Lys Ser Ile Ile  Asp Glu Phe 
    1220                 1225                 1230             


Leu His  Ile Asn Asp Phe Lys  Glu Ala Met Gln Cys  Val Glu Glu 
    1235                 1240                 1245             


Leu Asn  Ala Gln Gly Leu Leu  His Val Phe Val Arg  Val Gly Val 
    1250                 1255                 1260             


Glu Ser  Thr Leu Glu Arg Ser  Gln Ile Thr Arg Asp  His Met Gly 
    1265                 1270                 1275             


Gln Leu  Leu Tyr Gln Leu Val  Gln Ser Glu Lys Leu  Ser Lys Gln 
    1280                 1285                 1290             


Asp Phe  Phe Lys Gly Phe Ser  Glu Thr Leu Glu Leu  Ala Asp Asp 
    1295                 1300                 1305             


Met Ala  Ile Asp Ile Pro His  Ile Trp Leu Tyr Leu  Ala Glu Leu 
    1310                 1315                 1320             


Val Thr  Pro Met Leu Lys Glu  Gly Gly Ile Ser Met  Arg Glu Leu 
    1325                 1330                 1335             


Thr Ile  Glu Phe Ser Lys Pro  Leu Leu Pro Val Gly  Arg Ala Gly 
    1340                 1345                 1350             


Val Leu  Leu Ser Glu Ile Leu  His Leu Leu Cys Lys  Gln Met Ser 
    1355                 1360                 1365             


His Lys  Lys Val Gly Ala Leu  Trp Arg Glu Ala Asp  Leu Ser Trp 
    1370                 1375                 1380             


Lys Asp  Phe Leu Pro Glu Gly  Glu Asp Val His Asn  Phe Leu Leu 
    1385                 1390                 1395             


Glu Gln  Lys Leu Asp Phe Ile  Glu Ser Asp Ser Pro  Cys Ser Ser 
    1400                 1405                 1410             


Glu Ala  Leu Ser Lys Lys Glu  Leu Ser Ala Glu Glu  Leu Tyr Lys 
    1415                 1420                 1425             


Arg Leu  Glu Lys Leu Ile Ile  Glu Asp Lys Ala Asn  Asp Glu Gln 
    1430                 1435                 1440             


Ile Phe  Asp Trp Val Glu Ala  Asn Leu Asp Glu Ile  Gln Met Ser 
    1445                 1450                 1455             


Ser Pro  Thr Phe Leu Arg Ala  Leu Met Thr Ala Val  Cys Lys Ala 
    1460                 1465                 1470             


Ala Ile  Ile Ala Asp Ser Ser  Thr Phe Arg Val Asp  Thr Ala Val 
    1475                 1480                 1485             


Ile Lys  Gln Arg Val Pro Ile  Leu Leu Lys Tyr Leu  Asp Ser Asp 
    1490                 1495                 1500             


Thr Glu  Lys Glu Leu Gln Ala  Leu Tyr Ala Leu Gln  Ala Ser Ile 
    1505                 1510                 1515             


Val Lys  Leu Asp Gln Pro Ala  Asn Leu Leu Arg Met  Phe Phe Asp 
    1520                 1525                 1530             


Cys Leu  Tyr Asp Glu Glu Val  Ile Ser Glu Asp Ala  Phe Tyr Lys 
    1535                 1540                 1545             


Trp Glu  Ser Ser Lys Asp Pro  Ala Glu Gln Asn Gly  Lys Gly Val 
    1550                 1555                 1560             


Ala Leu  Lys Ser Val Thr Ala  Phe Phe Thr Trp Leu  Arg Glu Ala 
    1565                 1570                 1575             


Glu Glu  Glu Ser Glu Asp Asn  
    1580                 1585 


<210> 4949
<211> 125
<212> PRT
<213> Homo sapiens

<400> 4949
Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn 
        115                 120                 125 


<210> 4950
<211> 529
<212> PRT
<213> Homo sapiens

<400> 4950
Met Leu Val Leu Phe Glu Thr Ser Val Gly Tyr Ala Ile Phe Lys Val 
1               5                   10                  15      


Leu Asn Glu Lys Lys Leu Gln Glu Val Asp Ser Leu Trp Lys Glu Phe 
            20                  25                  30          


Glu Thr Pro Glu Lys Ala Asn Lys Ile Val Lys Leu Lys His Phe Glu 
        35                  40                  45              


Lys Phe Gln Asp Thr Ala Glu Ala Leu Ala Ala Phe Thr Ala Leu Met 
    50                  55                  60                  


Glu Gly Lys Ile Asn Lys Gln Leu Lys Lys Val Leu Lys Lys Ile Val 
65                  70                  75                  80  


Lys Glu Ala His Glu Pro Leu Ala Val Ala Asp Ala Lys Leu Gly Gly 
                85                  90                  95      


Val Ile Lys Glu Lys Leu Asn Leu Ser Cys Ile His Ser Pro Val Val 
            100                 105                 110         


Asn Glu Leu Met Arg Gly Ile Arg Ser Gln Met Asp Gly Leu Ile Pro 
        115                 120                 125             


Gly Val Glu Pro Arg Glu Met Ala Ala Met Cys Leu Gly Leu Ala His 
    130                 135                 140                 


Ser Leu Ser Arg Tyr Arg Leu Lys Phe Ser Ala Asp Lys Val Asp Thr 
145                 150                 155                 160 


Met Ile Val Gln Ala Ile Ser Leu Leu Asp Asp Leu Asp Lys Glu Leu 
                165                 170                 175     


Asn Asn Tyr Ile Met Arg Cys Arg Glu Trp Tyr Gly Trp His Phe Pro 
            180                 185                 190         


Glu Leu Gly Lys Ile Ile Ser Asp Asn Leu Thr Tyr Cys Lys Cys Leu 
        195                 200                 205             


Gln Lys Val Gly Asp Arg Lys Asn Tyr Ala Ser Ala Lys Leu Ser Glu 
    210                 215                 220                 


Leu Leu Pro Glu Glu Val Glu Ala Glu Val Lys Ala Ala Ala Glu Ile 
225                 230                 235                 240 


Ser Met Gly Thr Glu Val Ser Glu Glu Asp Ile Cys Asn Ile Leu His 
                245                 250                 255     


Leu Cys Thr Gln Val Ile Glu Ile Ser Glu Tyr Arg Thr Gln Leu Tyr 
            260                 265                 270         


Glu Tyr Leu Gln Asn Arg Met Met Ala Ile Ala Pro Asn Val Thr Val 
        275                 280                 285             


Met Val Gly Glu Leu Val Gly Ala Arg Leu Ile Ala His Ala Gly Ser 
    290                 295                 300                 


Leu Leu Asn Leu Ala Lys His Ala Ala Ser Thr Val Gln Ile Leu Gly 
305                 310                 315                 320 


Ala Glu Lys Ala Leu Phe Arg Ala Leu Lys Ser Arg Arg Asp Thr Pro 
                325                 330                 335     


Lys Tyr Gly Leu Ile Tyr His Ala Ser Leu Val Gly Gln Thr Ser Pro 
            340                 345                 350         


Lys His Lys Gly Lys Ile Ser Arg Met Leu Ala Ala Lys Thr Val Leu 
        355                 360                 365             


Ala Ile Arg Tyr Asp Ala Phe Gly Glu Asp Ser Ser Ser Ala Met Gly 
    370                 375                 380                 


Val Glu Asn Arg Ala Lys Leu Glu Ala Arg Leu Arg Thr Leu Glu Asp 
385                 390                 395                 400 


Arg Gly Ile Arg Lys Ile Ser Gly Thr Gly Lys Ala Leu Ala Lys Thr 
                405                 410                 415     


Glu Lys Tyr Glu His Lys Ser Glu Val Lys Thr Tyr Asp Pro Ser Gly 
            420                 425                 430         


Asp Ser Thr Leu Pro Thr Cys Ser Lys Lys Arg Lys Ile Glu Gln Val 
        435                 440                 445             


Asp Lys Glu Asp Glu Ile Thr Glu Lys Lys Ala Lys Lys Ala Lys Ile 
    450                 455                 460                 


Lys Val Lys Val Glu Glu Glu Glu Glu Glu Lys Val Ala Glu Glu Glu 
465                 470                 475                 480 


Glu Thr Ser Val Lys Lys Lys Lys Lys Arg Gly Lys Lys Lys His Ile 
                485                 490                 495     


Lys Glu Glu Pro Leu Ser Glu Glu Glu Pro Cys Thr Ser Thr Ala Ile 
            500                 505                 510         


Ala Ser Pro Glu Lys Lys Lys Lys Lys Lys Lys Lys Arg Glu Asn Glu 
        515                 520                 525             


Asp 
    


<210> 4951
<211> 245
<212> PRT
<213> Homo sapiens

<400> 4951
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 
            180                 185                 190         


Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 
        195                 200                 205             


Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 
    210                 215                 220                 


Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 
225                 230                 235                 240 


Asp Thr Trp Asp Glu 
                245 


<210> 4952
<211> 581
<212> PRT
<213> Homo sapiens

<400> 4952
Met Glu Asp Val Asn Ser Asn Val Asn Ala Asp Gln Glu Val Arg Lys 
1               5                   10                  15      


Leu Gln Glu Leu Val Lys Lys Leu Glu Lys Gln Asn Glu Gln Leu Arg 
            20                  25                  30          


Ser Arg Ser Gly Ala Val Gln Gly Ala Gly Ser Leu Gly Pro Gly Ser 
        35                  40                  45              


Pro Val Arg Ala Gly Ala Ser Ile Pro Ser Ser Gly Ala Ala Ser Pro 
    50                  55                  60                  


Arg Gly Phe Pro Leu Gly Leu Ser Ala Lys Ser Gly Gly Gly Pro Gly 
65                  70                  75                  80  


Ser Gly Pro Arg Arg Thr Ser Ser Glu Glu Leu Arg Asp Ala Thr Ser 
                85                  90                  95      


Leu Leu Ala Ala Gly Glu Gly Gly Leu Leu Asp Glu Val Glu Pro Leu 
            100                 105                 110         


Arg Pro Asp Glu Leu Glu Arg Leu Ser Gly Trp Glu Glu Glu Glu Glu 
        115                 120                 125             


Ser Trp Leu Tyr Ser Ser Pro Lys Lys Lys Leu Thr Pro Met Gln Lys 
    130                 135                 140                 


Ser Val Ser Pro Leu Val Trp Cys Arg Gln Val Leu Asp Tyr Pro Ser 
145                 150                 155                 160 


Pro Asp Val Glu Cys Ala Lys Lys Ser Leu Ile His Lys Leu Asp Gln 
                165                 170                 175     


Thr Met Ser Ala Leu Lys Arg Gln Asn Leu Tyr Asn Asn Pro Phe Asn 
            180                 185                 190         


Ser Met Ser Tyr Thr Ser Pro Tyr Ser Pro Asn Ala Ser Ser Pro Tyr 
        195                 200                 205             


Ser Ser Gly Phe Asn Ser Pro Ser Ser Thr Pro Val Arg Pro Pro Ile 
    210                 215                 220                 


Val Lys Gln Leu Ile Leu Pro Gly Asn Ser Gly Asn Leu Lys Ser Ser 
225                 230                 235                 240 


Asp Arg Asn Pro Pro Leu Ser Pro Gln Ser Ser Ile Asp Ser Glu Leu 
                245                 250                 255     


Ser Ala Ser Glu Leu Asp Glu Asp Ser Ile Gly Ser Asn Tyr Lys Leu 
            260                 265                 270         


Asn Asp Val Thr Asp Val Gln Ile Leu Ala Arg Met Gln Glu Glu Ser 
        275                 280                 285             


Leu Arg Gln Glu Tyr Ala Ala Thr Thr Ser Arg Arg Ser Ser Gly Ser 
    290                 295                 300                 


Ser Cys Asn Ser Thr Arg Arg Gly Thr Phe Ser Asp Gln Glu Leu Asp 
305                 310                 315                 320 


Ala Gln Ser Leu Asp Asp Glu Asp Asp Asn Met His His Ala Val Tyr 
                325                 330                 335     


Pro Ala Val Asn Arg Phe Ser Pro Ser Pro Arg Asn Ser Pro Arg Pro 
            340                 345                 350         


Ser Pro Lys Gln Ser Pro Arg Asn Ser Pro Arg Ser Arg Ser Pro Ala 
        355                 360                 365             


Arg Gly Ile Glu Tyr Ser Arg Val Ser Pro Gln Pro Met Ile Ser Arg 
    370                 375                 380                 


Leu Gln Gln Pro Arg Leu Ser Leu Gln Gly His Pro Thr Asp Leu Gln 
385                 390                 395                 400 


Thr Ser Asn Val Lys Asn Glu Glu Lys Leu Arg Arg Ser Leu Pro Asn 
                405                 410                 415     


Leu Ser Arg Thr Ser Asn Thr Gln Val Asp Ser Val Lys Ser Ser Arg 
            420                 425                 430         


Ser Asp Ser Asn Phe Gln Val Pro Asn Gly Gly Ile Pro Arg Met Gln 
        435                 440                 445             


Pro Gln Ala Ser Ala Ile Pro Ser Pro Gly Lys Phe Arg Ser Pro Ala 
    450                 455                 460                 


Ala Pro Ser Pro Leu Ala Leu Arg Gln Pro Val Lys Ala Phe Ser Asn 
465                 470                 475                 480 


His Gly Ser Gly Ser Pro Gly Ser Gln Glu Ile Thr Gln Leu Thr Gln 
                485                 490                 495     


Thr Thr Ser Ser Pro Gly Pro Pro Met Val Gln Ser Thr Val Ser Ala 
            500                 505                 510         


Asn Pro Pro Ser Asn Ile Asn Ser Ala Thr Leu Thr Arg Pro Ala Gly 
        515                 520                 525             


Thr Thr Ala Met Arg Ser Gly Leu Pro Arg Pro Ser Ala Pro Ser Ala 
    530                 535                 540                 


Gly Gly Ile Pro Val Pro Arg Ser Lys Leu Ala Gln Pro Val Arg Arg 
545                 550                 555                 560 


Ser Leu Pro Ala Pro Lys Thr Tyr Gly Ser Met Lys Asp Asp Ser Trp 
                565                 570                 575     


Lys Asp Gly Cys Tyr 
            580     


<210> 4953
<211> 1050
<212> PRT
<213> Homo sapiens

<400> 4953
Met Leu Cys Trp Gly Tyr Trp Ser Leu Gly Gln Pro Gly Ile Ser Thr 
1               5                   10                  15      


Asn Leu Gln Gly Ile Val Ala Glu Pro Gln Val Cys Gly Phe Ile Ser 
            20                  25                  30          


Asp Arg Ser Val Lys Glu Val Ala Cys Gly Gly Asn His Ser Val Phe 
        35                  40                  45              


Leu Leu Glu Asp Gly Glu Val Tyr Thr Cys Gly Leu Asn Thr Lys Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Arg Glu Gly Asn Lys Pro Glu Gln Ile Gly Ala 
65                  70                  75                  80  


Leu Ala Asp Gln His Ile Ile His Val Ala Cys Gly Glu Ser His Ser 
                85                  90                  95      


Leu Ala Leu Ser Asp Arg Gly Gln Leu Phe Ser Trp Gly Ala Gly Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Met Thr Thr Glu Asp Ser Val Ala Val Pro 
        115                 120                 125             


Arg Leu Ile Gln Lys Leu Asn Gln Gln Thr Ile Leu Gln Val Ser Cys 
    130                 135                 140                 


Gly Asn Trp His Cys Leu Ala Leu Ala Ala Asp Gly Gln Phe Phe Thr 
145                 150                 155                 160 


Trp Gly Lys Asn Ser His Gly Gln Leu Gly Leu Gly Lys Glu Phe Pro 
                165                 170                 175     


Ser Gln Ala Ser Pro Gln Arg Val Arg Ser Leu Glu Gly Ile Pro Leu 
            180                 185                 190         


Ala Gln Val Ala Ala Gly Gly Ala His Ser Phe Ala Leu Ser Leu Ser 
        195                 200                 205             


Gly Ala Val Phe Gly Trp Gly Met Asn Asn Ala Gly Gln Leu Gly Leu 
    210                 215                 220                 


Ser Asp Glu Lys Asp Arg Glu Ser Pro Cys His Val Lys Leu Leu Arg 
225                 230                 235                 240 


Thr Gln Lys Val Val Tyr Ile Ser Cys Gly Glu Glu His Thr Ala Val 
                245                 250                 255     


Leu Thr Lys Ser Gly Gly Val Phe Thr Phe Gly Ala Gly Ser Cys Gly 
            260                 265                 270         


Gln Leu Gly His Asp Ser Met Asn Asp Glu Val Asn Pro Arg Arg Val 
        275                 280                 285             


Leu Glu Leu Met Gly Ser Glu Val Thr Gln Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Leu Ala Phe Val Pro Ser Ser Gly Leu Ile Tyr Ala Phe Gly 
305                 310                 315                 320 


Cys Gly Ala Arg Gly Gln Leu Gly Thr Gly His Thr Cys Asn Val Lys 
                325                 330                 335     


Cys Pro Ser Pro Val Lys Gly Tyr Trp Ala Ala His Ser Gly Gln Leu 
            340                 345                 350         


Ser Ala Arg Ala Asp Arg Phe Lys Tyr His Ile Val Lys Gln Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Thr Phe Val Leu Cys Ser Lys Tyr Glu Asn Tyr 
    370                 375                 380                 


Ser Pro Ala Val Asp Phe Arg Thr Met Asn Gln Ala His Tyr Thr Ser 
385                 390                 395                 400 


Leu Ile Asn Asp Glu Thr Ile Ala Val Trp Arg Gln Lys Leu Ser Glu 
                405                 410                 415     


His Asn Asn Ala Asn Thr Ile Asn Gly Val Val Gln Ile Leu Ser Ser 
            420                 425                 430         


Ala Ala Cys Trp Asn Gly Ser Phe Leu Glu Lys Lys Ile Asp Glu His 
        435                 440                 445             


Phe Lys Thr Ser Pro Lys Ile Pro Gly Ile Asp Leu Asn Ser Thr Arg 
    450                 455                 460                 


Val Leu Phe Glu Lys Leu Met Asn Ser Gln His Ser Met Ile Leu Glu 
465                 470                 475                 480 


Gln Ile Leu Asn Ser Phe Glu Ser Cys Leu Ile Pro Gln Leu Ser Ser 
                485                 490                 495     


Ser Pro Pro Asp Val Glu Ala Met Arg Ile Tyr Leu Ile Leu Pro Glu 
            500                 505                 510         


Phe Pro Leu Leu Gln Asp Ser Lys Tyr Tyr Ile Thr Leu Thr Ile Pro 
        515                 520                 525             


Leu Ala Met Ala Ile Leu Arg Leu Asp Thr Asn Pro Ser Lys Val Leu 
    530                 535                 540                 


Asp Asn Trp Trp Ser Gln Val Cys Pro Lys Tyr Phe Met Lys Leu Val 
545                 550                 555                 560 


Asn Leu Tyr Lys Gly Ala Val Leu Tyr Leu Leu Arg Gly Arg Lys Thr 
                565                 570                 575     


Phe Leu Ile Pro Val Leu Phe Asn Asn Tyr Ile Thr Ala Ala Leu Lys 
            580                 585                 590         


Leu Leu Glu Lys Leu Tyr Lys Val Asn Leu Lys Val Lys His Val Glu 
        595                 600                 605             


Tyr Asp Thr Phe Tyr Ile Pro Glu Ile Ser Asn Leu Val Asp Ile Gln 
    610                 615                 620                 


Glu Asp Tyr Leu Met Trp Phe Leu His Gln Ala Gly Met Lys Ala Arg 
625                 630                 635                 640 


Pro Ser Ile Ile Gln Asp Thr Val Thr Leu Cys Ser Tyr Pro Phe Ile 
                645                 650                 655     


Phe Asp Ala Gln Ala Lys Thr Lys Met Leu Gln Thr Asp Ala Glu Leu 
            660                 665                 670         


Gln Met Gln Val Ala Val Asn Gly Ala Asn Leu Gln Asn Val Phe Met 
        675                 680                 685             


Leu Leu Thr Leu Glu Pro Leu Leu Ala Arg Ser Pro Phe Leu Val Leu 
    690                 695                 700                 


His Val Arg Arg Asn Asn Leu Val Gly Asp Ala Leu Arg Glu Leu Ser 
705                 710                 715                 720 


Ile His Ser Asp Ile Asp Leu Lys Lys Pro Leu Lys Val Ile Phe Asp 
                725                 730                 735     


Gly Glu Glu Ala Val Asp Ala Gly Gly Val Thr Lys Glu Phe Phe Leu 
            740                 745                 750         


Leu Leu Leu Lys Glu Leu Leu Asn Pro Ile Tyr Gly Met Phe Thr Tyr 
        755                 760                 765             


Tyr Gln Asp Ser Asn Leu Leu Trp Phe Ser Asp Thr Cys Phe Val Glu 
    770                 775                 780                 


His Asn Trp Phe His Leu Ile Gly Ile Thr Cys Gly Leu Ala Ile Tyr 
785                 790                 795                 800 


Asn Ser Thr Val Val Asp Leu His Phe Pro Leu Ala Leu Tyr Lys Lys 
                805                 810                 815     


Leu Leu Asn Val Lys Pro Gly Leu Glu Asp Leu Lys Glu Leu Ser Pro 
            820                 825                 830         


Thr Glu Gly Arg Ser Leu Gln Glu Leu Leu Asp Tyr Pro Gly Glu Asp 
        835                 840                 845             


Val Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Cys Arg Glu Ser Tyr 
    850                 855                 860                 


Gly Val Ile Glu Gln Lys Lys Leu Ile Pro Gly Gly Asp Asn Val Thr 
865                 870                 875                 880 


Val Cys Lys Asp Asn Arg Gln Glu Phe Val Asp Ala Tyr Val Asn Tyr 
                885                 890                 895     


Val Phe Gln Ile Ser Val His Glu Trp Tyr Thr Ala Phe Ser Ser Gly 
            900                 905                 910         


Phe Leu Lys Val Cys Gly Gly Lys Val Leu Glu Leu Phe Gln Pro Ser 
        915                 920                 925             


Glu Leu Arg Ala Met Met Val Gly Asn Ser Asn Tyr Asn Trp Glu Glu 
    930                 935                 940                 


Leu Glu Glu Thr Ala Ile Tyr Lys Gly Asp Tyr Ser Ala Thr His Pro 
945                 950                 955                 960 


Thr Val Lys Leu Phe Trp Glu Thr Phe His Glu Phe Pro Leu Glu Lys 
                965                 970                 975     


Lys Lys Lys Phe Leu Leu Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile 
            980                 985                 990         


Tyr Gly Met Ala Ser Leu Gln Ile  Val Ile Gln Ser Thr  Ala Ser Gly 
        995                 1000                 1005             


Glu Glu  Tyr Leu Pro Val Ala  His Thr Cys Tyr Asn  Leu Leu Asp 
    1010                 1015                 1020             


Leu Pro  Lys Tyr Ser Ser Lys  Glu Ile Leu Ser Ala  Arg Leu Thr 
    1025                 1030                 1035             


Gln Ala  Leu Asp Asn Tyr Glu  Gly Phe Ser Leu Ala  
    1040                 1045                 1050 


<210> 4954
<211> 1022
<212> PRT
<213> Homo sapiens

<400> 4954
Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Ser Tyr His Thr Leu Ala Tyr Val His 
    290                 295                 300                 


Thr Thr Gly Gln Val Val Ser Phe Gly His Gly Pro Ser Asp Thr Ser 
305                 310                 315                 320 


Lys Pro Thr His Pro Glu Ala Leu Thr Glu Asn Phe Asp Ile Ser Cys 
                325                 330                 335     


Leu Ile Ser Ala Glu Asp Phe Val Asp Val Gln Val Lys His Ile Phe 
            340                 345                 350         


Ala Gly Thr Tyr Ala Asn Phe Val Thr Thr His Gln Asp Thr Ser Ser 
        355                 360                 365             


Thr Arg Ala Pro Gly Lys Thr Leu Pro Glu Ile Ser Arg Ile Ser Gln 
    370                 375                 380                 


Ser Met Ala Glu Lys Trp Ile Ala Val Lys Arg Arg Ser Thr Glu His 
385                 390                 395                 400 


Glu Met Ala Lys Ser Glu Ile Arg Met Ile Phe Ser Ser Pro Ala Cys 
                405                 410                 415     


Leu Thr Ala Ser Phe Leu Lys Lys Arg Gly Thr Gly Glu Thr Thr Ser 
            420                 425                 430         


Ile Asp Val Asp Leu Glu Met Ala Arg Asp Thr Phe Lys Lys Leu Thr 
        435                 440                 445             


Lys Lys Glu Trp Ile Ser Ser Met Ile Thr Thr Cys Leu Glu Asp Asp 
    450                 455                 460                 


Leu Leu Arg Ala Leu Pro Cys His Ser Pro His Gln Glu Ala Leu Ser 
465                 470                 475                 480 


Val Phe Leu Leu Leu Pro Glu Cys Pro Val Met His Asp Ser Lys Asn 
                485                 490                 495     


Trp Lys Asn Leu Val Val Pro Phe Ala Lys Ala Val Cys Glu Met Ser 
            500                 505                 510         


Lys Gln Ser Leu Gln Val Leu Lys Lys Cys Trp Ala Phe Leu Gln Glu 
        515                 520                 525             


Ser Ser Leu Asn Pro Leu Ile Gln Met Leu Lys Ala Ala Ile Ile Ser 
    530                 535                 540                 


Gln Leu Leu His Gln Thr Lys Thr Glu Gln Asp His Cys Asn Val Lys 
545                 550                 555                 560 


Ala Leu Leu Gly Met Met Lys Glu Leu His Lys Val Asn Lys Ala Asn 
                565                 570                 575     


Cys Arg Leu Pro Glu Asn Thr Phe Asn Ile Asn Glu Leu Ser Asn Leu 
            580                 585                 590         


Leu Asn Phe Tyr Ile Asp Arg Gly Arg Gln Leu Phe Arg Asp Asn His 
        595                 600                 605             


Leu Ile Pro Ala Glu Thr Pro Ser Pro Val Ile Phe Ser Asp Phe Pro 
    610                 615                 620                 


Phe Ile Phe Asn Ser Leu Ser Lys Ile Lys Leu Leu Gln Ala Asp Ser 
625                 630                 635                 640 


His Ile Lys Met Gln Met Ser Glu Lys Lys Ala Tyr Met Leu Met His 
                645                 650                 655     


Glu Thr Ile Leu Gln Lys Lys Asp Glu Phe Pro Pro Ser Pro Arg Phe 
            660                 665                 670         


Ile Leu Arg Val Arg Arg Ser Arg Leu Val Lys Asp Ala Leu Arg Gln 
        675                 680                 685             


Leu Ser Gln Ala Glu Ala Thr Asp Phe Cys Lys Val Leu Val Val Glu 
    690                 695                 700                 


Phe Ile Asn Glu Ile Cys Pro Glu Ser Gly Gly Val Ser Ser Glu Phe 
705                 710                 715                 720 


Phe His Cys Met Phe Glu Glu Met Thr Lys Pro Glu Tyr Gly Met Phe 
                725                 730                 735     


Met Tyr Pro Glu Met Gly Ser Cys Met Trp Phe Pro Ala Lys Pro Lys 
            740                 745                 750         


Pro Glu Lys Lys Arg Tyr Phe Leu Phe Gly Met Leu Cys Gly Leu Ser 
        755                 760                 765             


Leu Phe Asn Leu Asn Val Ala Asn Leu Pro Phe Pro Leu Ala Leu Tyr 
    770                 775                 780                 


Lys Lys Leu Leu Asp Gln Lys Pro Ser Leu Glu Asp Leu Lys Glu Leu 
785                 790                 795                 800 


Ser Pro Arg Leu Gly Lys Ser Leu Gln Glu Val Leu Asp Asp Ala Ala 
                805                 810                 815     


Asp Asp Ile Gly Asp Ala Leu Cys Ile Arg Phe Ser Ile His Trp Asp 
            820                 825                 830         


Gln Asn Asp Val Asp Leu Ile Pro Asn Gly Ile Ser Ile Pro Val Asp 
        835                 840                 845             


Gln Thr Asn Lys Arg Asp Tyr Val Ser Lys Tyr Ile Asp Tyr Ile Phe 
    850                 855                 860                 


Asn Val Ser Val Lys Ala Val Tyr Glu Glu Phe Gln Arg Gly Phe Tyr 
865                 870                 875                 880 


Arg Val Cys Glu Lys Glu Ile Leu Arg His Phe Tyr Pro Glu Glu Leu 
                885                 890                 895     


Met Thr Ala Ile Ile Gly Asn Thr Asp Tyr Asp Trp Lys Gln Phe Glu 
            900                 905                 910         


Gln Asn Ser Lys Tyr Glu Gln Gly Tyr Gln Lys Ser His Pro Thr Ile 
        915                 920                 925             


Gln Leu Phe Trp Lys Ala Phe His Lys Leu Thr Leu Asp Glu Lys Lys 
    930                 935                 940                 


Lys Phe Leu Phe Phe Leu Thr Gly Arg Asp Arg Leu His Ala Arg Gly 
945                 950                 955                 960 


Ile Gln Lys Met Glu Ile Val Phe Arg Cys Pro Glu Thr Phe Ser Glu 
                965                 970                 975     


Arg Asp His Pro Thr Ser Ile Thr Cys His Asn Ile Leu Ser Leu Pro 
            980                 985                 990         


Lys Tyr Ser Thr Met Glu Arg Met  Glu Glu Ala Leu Gln  Val Ala Ile 
        995                 1000                 1005             


Asn Asn  Asn Arg Gly Phe Val  Ser Pro Met Leu Thr  Gln Ser 
    1010                 1015                 1020         


<210> 4955
<211> 406
<212> PRT
<213> Homo sapiens

<400> 4955
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gln Ile Leu Glu Lys 
            20                  25                  30          


Ala Ile Gln Leu Ser Gly Ala Glu Gln Leu Glu Ala Leu Lys Ala Phe 
        35                  40                  45              


Val Glu Ala Met Val Asn Glu Asn Val Ser Leu Val Ile Ser Arg Gln 
    50                  55                  60                  


Leu Leu Thr Asp Phe Cys Thr His Leu Pro Asn Leu Pro Asp Ser Thr 
65                  70                  75                  80  


Ala Lys Glu Ile Tyr His Phe Thr Leu Glu Lys Ile Gln Pro Arg Val 
                85                  90                  95      


Ile Ser Phe Glu Glu Gln Val Ala Ser Ile Arg Gln His Leu Ala Ser 
            100                 105                 110         


Ile Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gln Val Leu Val 
        115                 120                 125             


Gly Ile Pro Leu Glu Thr Gly Gln Lys Gln Tyr Asn Val Asp Tyr Lys 
    130                 135                 140                 


Leu Glu Thr Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
145                 150                 155                 160 


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
                165                 170                 175     


Glu Ser Thr Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
            180                 185                 190         


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
        195                 200                 205             


Asn Glu Leu Ser Tyr Lys Thr Ile Val His Glu Ser Glu Arg Leu Glu 
    210                 215                 220                 


Ala Leu Lys His Ala Leu His Cys Thr Ile Leu Ala Ser Ala Gly Gln 
225                 230                 235                 240 


Gln Arg Ser Arg Met Leu Ala Thr Leu Phe Lys Asp Glu Arg Cys Gln 
                245                 250                 255     


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
            260                 265                 270         


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
        275                 280                 285             


Gln Lys Ala Thr Thr Ala Asp Gly Ser Ser Ile Leu Asp Arg Ala Val 
    290                 295                 300                 


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Thr 
305                 310                 315                 320 


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys Ala Glu 
                325                 330                 335     


Lys Ile Ala Ser Gln Met Ile Thr Glu Gly Arg Met Asn Gly Phe Ile 
            340                 345                 350         


Asp Gln Ile Asp Gly Ile Val His Phe Glu Thr Arg Glu Ala Leu Pro 
        355                 360                 365             


Thr Trp Asp Lys Gln Ile Gln Ser Leu Cys Phe Gln Val Asn Asn Leu 
    370                 375                 380                 


Leu Glu Lys Ile Ser Gln Thr Ala Pro Glu Trp Thr Ala Gln Ala Met 
385                 390                 395                 400 


Glu Ala Gln Met Ala Gln 
                405     


<210> 4956
<211> 525
<212> PRT
<213> Homo sapiens

<400> 4956
Met Ala Ala Gly Leu Leu Gly Ser Glu Asp Pro Pro Trp Ser Trp Asn 
1               5                   10                  15      


Leu Thr Cys Arg Ala Leu Arg Thr Cys Gln Val Arg Asn Ile Arg Val 
            20                  25                  30          


Leu Gln Leu Leu Leu Lys Pro Trp Cys Ile Ser Arg Ala Val Tyr Gln 
        35                  40                  45              


Met Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys 
    50                  55                  60                  


Leu Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp 
65                  70                  75                  80  


Leu Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile 
                85                  90                  95      


Ala Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg 
            100                 105                 110         


Arg Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu 
        115                 120                 125             


Tyr Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp 
    130                 135                 140                 


Asn Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr 
145                 150                 155                 160 


Lys Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser 
                165                 170                 175     


Tyr Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val 
            180                 185                 190         


Arg Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys 
        195                 200                 205             


Glu His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr 
    210                 215                 220                 


Lys Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met 
225                 230                 235                 240 


Ser Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val 
                245                 250                 255     


Lys Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly 
            260                 265                 270         


Ile Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe 
        275                 280                 285             


Gln Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser 
    290                 295                 300                 


Val Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe 
305                 310                 315                 320 


Gly His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu 
                325                 330                 335     


Ile Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu 
            340                 345                 350         


Asp Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser 
        355                 360                 365             


Glu Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys 
    370                 375                 380                 


Leu Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly 
385                 390                 395                 400 


Ser Leu Leu Ser Ser Gly Ser Gln Glu Ser Asp Ser Ser Gln Ser Ala 
                405                 410                 415     


Lys Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gln Glu Ala Leu Glu 
            420                 425                 430         


Glu Thr Leu Arg Gln Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu Arg 
        435                 440                 445             


Glu Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro Leu Asp Pro 
    450                 455                 460                 


Gly Glu Glu Pro Pro Ile Val Arg Arg Arg Ile Gly Thr Ala Phe Lys 
465                 470                 475                 480 


Leu Asp Glu Gln Lys Ile Leu Pro Lys Gly Glu Glu Ala Glu Leu Glu 
                485                 490                 495     


Arg Leu Glu Arg Glu Phe Ala Ile Gln Ser Gln Ile Thr Glu Ala Ala 
            500                 505                 510         


Arg Arg Leu Ala Ser Asp Pro Asn Val Ser Lys Lys Leu 
        515                 520                 525 


<210> 4957
<211> 534
<212> PRT
<213> Homo sapiens

<400> 4957
Met Lys Gln Glu Gly Ser Ala Arg Arg Arg Gly Ala Asp Lys Ala Lys 
1               5                   10                  15      


Pro Pro Pro Gly Gly Gly Glu Gln Glu Pro Pro Pro Pro Pro Ala Pro 
            20                  25                  30          


Gln Asp Val Glu Met Lys Glu Glu Ala Ala Thr Gly Gly Gly Ser Thr 
        35                  40                  45              


Gly Glu Ala Asp Gly Lys Thr Ala Ala Ala Ala Ala Glu His Ser Gln 
    50                  55                  60                  


Arg Glu Leu Asp Thr Val Thr Leu Glu Asp Ile Lys Glu His Val Lys 
65                  70                  75                  80  


Gln Leu Glu Lys Ala Val Ser Gly Lys Glu Pro Arg Phe Val Leu Arg 
                85                  90                  95      


Ala Leu Arg Met Leu Pro Ser Thr Ser Arg Arg Leu Asn His Tyr Val 
            100                 105                 110         


Leu Tyr Lys Ala Val Gln Gly Phe Phe Thr Ser Asn Asn Ala Thr Arg 
        115                 120                 125             


Asp Phe Leu Leu Pro Phe Leu Glu Glu Pro Met Asp Thr Glu Ala Asp 
    130                 135                 140                 


Leu Gln Phe Arg Pro Arg Thr Gly Lys Ala Ala Ser Thr Pro Leu Leu 
145                 150                 155                 160 


Pro Glu Val Glu Ala Tyr Leu Gln Leu Leu Val Val Ile Phe Met Met 
                165                 170                 175     


Asn Ser Lys Arg Tyr Lys Glu Ala Gln Lys Ile Ser Asp Asp Leu Met 
            180                 185                 190         


Gln Lys Ile Ser Thr Gln Asn Arg Arg Ala Leu Asp Leu Val Ala Ala 
        195                 200                 205             


Lys Cys Tyr Tyr Tyr His Ala Arg Val Tyr Glu Phe Leu Asp Lys Leu 
    210                 215                 220                 


Asp Val Val Arg Ser Phe Leu His Ala Arg Leu Arg Thr Ala Thr Leu 
225                 230                 235                 240 


Arg His Asp Ala Asp Gly Gln Ala Thr Leu Leu Asn Leu Leu Leu Arg 
                245                 250                 255     


Asn Tyr Leu His Tyr Ser Leu Tyr Asp Gln Ala Glu Lys Leu Val Ser 
            260                 265                 270         


Lys Ser Val Phe Pro Glu Gln Ala Asn Asn Asn Glu Trp Ala Arg Tyr 
        275                 280                 285             


Leu Tyr Tyr Thr Gly Arg Ile Lys Ala Ile Gln Leu Glu Tyr Ser Glu 
    290                 295                 300                 


Ala Arg Arg Thr Met Thr Asn Ala Leu Arg Lys Ala Pro Gln His Thr 
305                 310                 315                 320 


Ala Val Gly Phe Lys Gln Thr Val His Lys Leu Leu Ile Val Val Glu 
                325                 330                 335     


Leu Leu Leu Gly Glu Ile Pro Asp Arg Leu Gln Phe Arg Gln Pro Ser 
            340                 345                 350         


Leu Lys Arg Ser Leu Met Pro Tyr Phe Leu Leu Thr Gln Ala Val Arg 
        355                 360                 365             


Thr Gly Asn Leu Ala Lys Phe Asn Gln Val Leu Asp Gln Phe Gly Glu 
    370                 375                 380                 


Lys Phe Gln Ala Asp Gly Thr Tyr Thr Leu Ile Ile Arg Leu Arg His 
385                 390                 395                 400 


Asn Val Ile Lys Thr Gly Val Arg Met Ile Ser Leu Ser Tyr Ser Arg 
                405                 410                 415     


Ile Ser Leu Ala Asp Ile Ala Gln Lys Leu Gln Leu Asp Ser Pro Glu 
            420                 425                 430         


Asp Ala Glu Phe Ile Val Ala Lys Ala Ile Arg Asp Gly Val Ile Glu 
        435                 440                 445             


Ala Ser Ile Asn His Glu Lys Gly Tyr Val Gln Ser Lys Glu Met Ile 
    450                 455                 460                 


Asp Ile Tyr Ser Thr Arg Glu Pro Gln Leu Ala Phe His Gln Arg Ile 
465                 470                 475                 480 


Ser Phe Cys Leu Asp Ile His Asn Met Ser Val Lys Ala Met Arg Phe 
                485                 490                 495     


Pro Pro Lys Ser Tyr Asn Lys Asp Leu Glu Ser Ala Glu Glu Arg Arg 
            500                 505                 510         


Glu Arg Glu Gln Gln Asp Leu Glu Phe Ala Lys Glu Met Ala Glu Asp 
        515                 520                 525             


Asp Asp Asp Ser Phe Pro 
    530                 


<210> 4958
<211> 436
<212> PRT
<213> Homo sapiens

<400> 4958
Met Arg Arg Asp Val Asn Gly Val Thr Lys Ser Arg Phe Glu Met Phe 
1               5                   10                  15      


Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro Lys Glu Leu 
            20                  25                  30          


Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu Cys Arg Cys 
        35                  40                  45              


Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile Glu Gly Arg 
65                  70                  75                  80  


Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu Arg Lys Leu 
                85                  90                  95      


Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu Arg Thr Phe 
            100                 105                 110         


Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn Gly Cys Thr 
        115                 120                 125             


Lys Thr Thr Asp Ala Thr Cys Thr Ser Leu Ser Lys Phe Cys Ser Lys 
    130                 135                 140                 


Leu Arg His Leu Asp Leu Ala Ser Cys Thr Ser Ile Thr Asn Met Ser 
145                 150                 155                 160 


Leu Lys Ala Leu Ser Glu Gly Cys Pro Leu Leu Glu Gln Leu Asn Ile 
                165                 170                 175     


Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala Leu Val Arg 
            180                 185                 190         


Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys Thr Gln Leu 
        195                 200                 205             


Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro Glu Leu Val 
    210                 215                 220                 


Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu Gly Leu Ile 
225                 230                 235                 240 


Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys Ala Ser Gly 
                245                 250                 255     


Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly Gln Asn Cys 
            260                 265                 270         


Pro Arg Leu Arg Ile Leu Glu Val Ala Arg Cys Ser Gln Leu Thr Asp 
        275                 280                 285             


Val Gly Phe Thr Thr Leu Ala Arg Asn Cys His Glu Leu Glu Lys Met 
    290                 295                 300                 


Asp Leu Glu Glu Cys Val Gln Ile Thr Asp Ser Thr Leu Ile Gln Leu 
305                 310                 315                 320 


Ser Ile His Cys Pro Arg Leu Gln Val Leu Ser Leu Ser His Cys Glu 
                325                 330                 335     


Leu Ile Thr Asp Asp Gly Ile Arg His Leu Gly Asn Gly Ala Cys Ala 
            340                 345                 350         


His Asp Gln Leu Glu Val Ile Glu Leu Asp Asn Cys Pro Leu Ile Thr 
        355                 360                 365             


Asp Ala Ser Leu Glu His Leu Lys Ser Cys His Ser Leu Glu Arg Ile 
    370                 375                 380                 


Glu Leu Tyr Asp Cys Gln Gln Ile Thr Arg Ala Gly Ile Lys Arg Leu 
385                 390                 395                 400 


Arg Thr His Leu Pro Asn Ile Lys Val His Ala Tyr Phe Ala Pro Val 
                405                 410                 415     


Thr Pro Pro Pro Ser Val Gly Gly Ser Arg Gln Arg Phe Cys Arg Cys 
            420                 425                 430         


Cys Ile Ile Leu 
        435     


<210> 4959
<211> 388
<212> PRT
<213> Homo sapiens

<400> 4959
Met Arg Cys Leu Tyr Gly Arg Val Gly Gly Ala Arg Arg Lys Met Ala 
1               5                   10                  15      


Ala Ser Ala Ala Ala Ala Glu Leu Gln Ala Ser Gly Gly Pro Arg His 
            20                  25                  30          


Pro Val Cys Leu Leu Val Leu Gly Met Ala Gly Ser Gly Lys Thr Thr 
        35                  40                  45              


Phe Val Gln Arg Leu Thr Gly His Leu His Ala Gln Gly Thr Pro Pro 
    50                  55                  60                  


Tyr Val Ile Asn Leu Asp Pro Ala Val His Glu Val Pro Phe Pro Ala 
65                  70                  75                  80  


Asn Ile Asp Ile Arg Asp Thr Val Lys Tyr Lys Glu Val Met Lys Gln 
                85                  90                  95      


Tyr Gly Leu Gly Pro Asn Gly Gly Ile Val Thr Ser Leu Asn Leu Phe 
            100                 105                 110         


Ala Thr Arg Phe Asp Gln Val Met Lys Phe Ile Glu Lys Ala Gln Asn 
        115                 120                 125             


Met Ser Lys Tyr Val Leu Ile Asp Thr Pro Gly Gln Ile Glu Val Phe 
    130                 135                 140                 


Thr Trp Ser Ala Ser Gly Thr Ile Ile Thr Glu Ala Leu Ala Ser Ser 
145                 150                 155                 160 


Phe Pro Thr Val Val Ile Tyr Val Met Asp Thr Ser Arg Ser Thr Asn 
                165                 170                 175     


Pro Val Thr Phe Met Ser Asn Met Leu Tyr Ala Cys Ser Ile Leu Tyr 
            180                 185                 190         


Lys Thr Lys Leu Pro Phe Ile Val Val Met Asn Lys Thr Asp Ile Ile 
        195                 200                 205             


Asp His Ser Phe Ala Val Glu Trp Met Gln Asp Phe Glu Ala Phe Gln 
    210                 215                 220                 


Asp Ala Leu Asn Gln Glu Thr Thr Tyr Val Ser Asn Leu Thr Arg Ser 
225                 230                 235                 240 


Met Ser Leu Val Leu Asp Glu Phe Tyr Ser Ser Leu Arg Val Val Gly 
                245                 250                 255     


Val Ser Ala Val Leu Gly Thr Gly Leu Asp Glu Leu Phe Val Gln Val 
            260                 265                 270         


Thr Ser Ala Ala Glu Glu Tyr Glu Arg Glu Tyr Arg Pro Glu Tyr Glu 
        275                 280                 285             


Arg Leu Lys Lys Ser Leu Ala Asn Ala Glu Ser Gln Gln Gln Arg Glu 
    290                 295                 300                 


Gln Leu Glu Arg Leu Arg Lys Asp Met Gly Ser Val Ala Leu Asp Ala 
305                 310                 315                 320 


Gly Thr Ala Lys Asp Ser Leu Ser Pro Val Leu His Pro Ser Asp Leu 
                325                 330                 335     


Ile Leu Thr Arg Gly Thr Leu Asp Glu Glu Asp Glu Glu Ala Asp Ser 
            340                 345                 350         


Asp Thr Asp Asp Ile Asp His Arg Val Thr Glu Glu Ser His Glu Glu 
        355                 360                 365             


Pro Ala Phe Gln Asn Phe Met Gln Glu Ser Met Ala Gln Tyr Trp Lys 
    370                 375                 380                 


Arg Asn Asn Lys 
385             


<210> 4960
<211> 555
<212> PRT
<213> Homo sapiens

<400> 4960
Met Arg Leu Ile Gly Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro 
1               5                   10                  15      


Arg Arg Ile Tyr Thr Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys 
            20                  25                  30          


Lys Ser His Trp Ala Glu Leu Glu Ile Ser Gly Arg Val Arg Ser Leu 
        35                  40                  45              


Ser Thr Ser Leu Trp Ser Leu Thr His Leu Thr Ala Leu His Leu Asn 
    50                  55                  60                  


Asp Asn Tyr Leu Ser Arg Ile Pro Pro Asp Ile Ala Lys Leu His Asn 
65                  70                  75                  80  


Leu Val Tyr Leu Asp Leu Ser Ser Asn Lys Leu Arg Ser Leu Pro Ala 
                85                  90                  95      


Glu Leu Gly Asn Met Val Ser Leu Arg Glu Leu Leu Leu Asn Asn Asn 
            100                 105                 110         


Leu Leu Arg Val Leu Pro Tyr Glu Leu Gly Arg Leu Phe Gln Leu Gln 
        115                 120                 125             


Thr Leu Gly Leu Lys Gly Asn Pro Leu Ser Gln Asp Ile Leu Asn Leu 
    130                 135                 140                 


Tyr Gln Asp Pro Asp Gly Thr Arg Lys Leu Leu Asn Phe Met Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Val His Pro Glu Gln Leu Pro Pro Arg Pro Trp Ile Thr 
                165                 170                 175     


Leu Lys Glu Arg Asp Gln Ile Leu Pro Ser Ala Ser Phe Thr Val Met 
            180                 185                 190         


Cys Tyr Asn Val Leu Cys Asp Lys Tyr Ala Thr Arg Gln Leu Tyr Gly 
        195                 200                 205             


Tyr Cys Pro Ser Trp Ala Leu Asn Trp Glu Tyr Arg Lys Lys Gly Ile 
    210                 215                 220                 


Met Glu Glu Ile Val Asn Cys Asp Ala Asp Ile Ile Ser Leu Gln Glu 
225                 230                 235                 240 


Val Glu Thr Glu Gln Tyr Phe Thr Leu Phe Leu Pro Ala Leu Lys Glu 
                245                 250                 255     


Arg Gly Tyr Asp Gly Phe Phe Ser Pro Lys Ser Arg Ala Lys Ile Met 
            260                 265                 270         


Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys 
        275                 280                 285             


Thr Glu Lys Phe Thr Leu Val Gln Lys His Thr Val Glu Phe Asn Gln 
    290                 295                 300                 


Val Ala Met Ala Asn Ser Asp Gly Ser Glu Ala Met Leu Asn Arg Val 
305                 310                 315                 320 


Met Thr Lys Asp Asn Ile Gly Val Ala Val Val Leu Glu Val His Lys 
                325                 330                 335     


Glu Leu Phe Gly Ala Gly Met Lys Pro Ile His Ala Ala Asp Lys Gln 
            340                 345                 350         


Leu Leu Ile Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr Ser 
        355                 360                 365             


Asp Val Lys Leu Ile Gln Thr Met Met Phe Val Ser Glu Val Lys Asn 
    370                 375                 380                 


Ile Leu Glu Lys Ala Ser Ser Arg Pro Gly Ser Pro Thr Ala Asp Pro 
385                 390                 395                 400 


Asn Ser Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu Pro Asp 
                405                 410                 415     


Ser Gly Val Val Glu Tyr Leu Ser Asn Gly Gly Val Ala Asp Asn His 
            420                 425                 430         


Lys Asp Phe Lys Glu Leu Arg Tyr Asn Glu Cys Leu Met Asn Phe Ser 
        435                 440                 445             


Cys Asn Gly Lys Asn Gly Ser Ser Glu Gly Arg Ile Thr His Gly Phe 
    450                 455                 460                 


Gln Leu Lys Ser Ala Tyr Glu Asn Asn Leu Met Pro Tyr Thr Asn Tyr 
465                 470                 475                 480 


Thr Phe Asp Phe Lys Gly Val Ile Asp Tyr Ile Phe Tyr Ser Lys Thr 
                485                 490                 495     


His Met Asn Val Leu Gly Val Leu Gly Pro Leu Asp Pro Gln Trp Leu 
            500                 505                 510         


Val Glu Asn Asn Ile Thr Gly Cys Pro His Pro His Ile Pro Ser Asp 
        515                 520                 525             


His Phe Ser Leu Leu Thr Gln Leu Glu Leu His Pro Pro Leu Leu Pro 
    530                 535                 540                 


Leu Val Asn Gly Val His Leu Pro Asn Arg Arg 
545                 550                 555 


<210> 4961
<211> 890
<212> PRT
<213> Homo sapiens

<400> 4961
Ser Ser Asp Ser Glu Ile Ile Gly Tyr Ala Leu Asp Thr Leu Tyr Asn 
1               5                   10                  15      


Ile Ile Ser Asn Glu Glu Glu Glu Glu Val Glu Glu Asn Ser Thr Arg 
            20                  25                  30          


Gln Ser Glu Asp Leu Gly Ser Gln Phe Thr Glu Ile Phe Ile Lys Gln 
        35                  40                  45              


Gln Glu Asn Val Thr Leu Leu Leu Ser Leu Leu Glu Glu Phe Asp Phe 
    50                  55                  60                  


His Val Arg Trp Pro Gly Val Lys Leu Leu Thr Ser Leu Leu Lys Gln 
65                  70                  75                  80  


Leu Gly Pro Gln Val Gln Gln Ile Ile Leu Val Ser Pro Met Gly Val 
                85                  90                  95      


Ser Arg Leu Met Asp Leu Leu Ala Asp Ser Arg Glu Val Ile Arg Asn 
            100                 105                 110         


Asp Gly Val Leu Leu Leu Gln Ala Leu Thr Arg Ser Asn Gly Ala Ile 
        115                 120                 125             


Gln Lys Ile Val Ala Phe Glu Asn Ala Phe Glu Arg Leu Leu Asp Ile 
    130                 135                 140                 


Ile Ser Glu Glu Gly Asn Ser Asp Gly Gly Ile Val Val Glu Asp Cys 
145                 150                 155                 160 


Leu Ile Leu Leu Gln Asn Leu Leu Lys Asn Asn Asn Ser Asn Gln Asn 
                165                 170                 175     


Phe Phe Lys Glu Gly Ser Tyr Ile Gln Arg Met Lys Pro Trp Phe Glu 
            180                 185                 190         


Val Gly Asp Glu Asn Ser Gly Trp Ser Ala Gln Lys Val Thr Asn Leu 
        195                 200                 205             


His Leu Met Leu Gln Leu Val Arg Val Leu Val Ser Pro Thr Asn Pro 
    210                 215                 220                 


Pro Gly Ala Thr Ser Ser Cys Gln Lys Ala Met Phe Gln Cys Gly Leu 
225                 230                 235                 240 


Leu Gln Gln Leu Cys Thr Ile Leu Met Ala Thr Gly Val Pro Ala Asp 
                245                 250                 255     


Ile Leu Thr Glu Thr Ile Asn Thr Val Ser Glu Val Ile Arg Gly Cys 
            260                 265                 270         


Gln Val Asn Gln Asp Tyr Phe Ala Ser Val Asn Ala Pro Ser Asn Pro 
        275                 280                 285             


Pro Arg Pro Ala Ile Val Val Leu Leu Met Ser Met Val Asn Glu Arg 
    290                 295                 300                 


Gln Pro Phe Val Leu Arg Cys Ala Val Leu Tyr Cys Phe Gln Cys Phe 
305                 310                 315                 320 


Leu Tyr Lys Asn Gln Lys Gly Gln Gly Glu Ile Val Ser Thr Leu Leu 
                325                 330                 335     


Pro Ser Thr Ile Asp Ala Thr Gly Asn Ser Val Ser Ala Gly Gln Leu 
            340                 345                 350         


Leu Cys Gly Gly Leu Phe Ser Thr Asp Ser Leu Ser Asn Trp Cys Ala 
        355                 360                 365             


Ala Val Ala Leu Ala His Ala Leu Gln Glu Asn Ala Thr Gln Lys Glu 
    370                 375                 380                 


Gln Leu Leu Arg Val Gln Leu Ala Thr Ser Ile Gly Asn Pro Pro Val 
385                 390                 395                 400 


Ser Leu Leu Gln Gln Cys Thr Asn Ile Leu Ser Gln Gly Ser Lys Ile 
                405                 410                 415     


Gln Thr Arg Val Gly Leu Leu Met Leu Leu Cys Thr Trp Leu Ser Asn 
            420                 425                 430         


Cys Pro Ile Ala Val Thr His Phe Leu His Asn Ser Ala Asn Val Pro 
        435                 440                 445             


Phe Leu Thr Gly Gln Ile Ala Glu Asn Leu Gly Glu Glu Glu Gln Leu 
    450                 455                 460                 


Val Gln Gly Leu Cys Ala Leu Leu Leu Gly Ile Ser Ile Tyr Phe Asn 
465                 470                 475                 480 


Asp Asn Ser Leu Glu Ser Tyr Met Lys Glu Lys Leu Lys Gln Leu Ile 
                485                 490                 495     


Glu Lys Arg Ile Gly Lys Glu Asn Phe Ile Glu Lys Leu Gly Phe Ile 
            500                 505                 510         


Ser Lys His Glu Leu Tyr Ser Arg Ala Ser Gln Lys Pro Gln Pro Asn 
        515                 520                 525             


Phe Pro Ser Pro Glu Tyr Met Ile Phe Asp His Glu Phe Thr Lys Leu 
    530                 535                 540                 


Val Lys Glu Leu Glu Gly Val Ile Thr Lys Ala Ile Tyr Lys Ser Ser 
545                 550                 555                 560 


Glu Glu Asp Lys Lys Glu Glu Glu Val Lys Lys Thr Leu Glu Gln His 
                565                 570                 575     


Asp Asn Ile Val Thr His Tyr Lys Asn Met Ile Arg Glu Gln Asp Leu 
            580                 585                 590         


Gln Leu Glu Glu Leu Arg Gln Gln Val Ser Thr Leu Lys Cys Gln Asn 
        595                 600                 605             


Glu Gln Leu Gln Thr Ala Val Thr Gln Gln Val Ser Gln Ile Gln Gln 
    610                 615                 620                 


His Lys Asp Gln Tyr Asn Leu Leu Lys Ile Gln Leu Gly Lys Asp Asn 
625                 630                 635                 640 


Gln His Gln Gly Ser Tyr Ser Glu Gly Ala Gln Met Asn Gly Ile Gln 
                645                 650                 655     


Pro Glu Glu Ile Gly Arg Leu Arg Glu Glu Ile Glu Glu Leu Lys Arg 
            660                 665                 670         


Asn Gln Glu Leu Leu Gln Ser Gln Leu Thr Glu Lys Asp Ser Met Ile 
        675                 680                 685             


Glu Asn Met Lys Ser Ser Gln Thr Ser Gly Thr Asn Glu Gln Ser Ser 
    690                 695                 700                 


Ala Ile Val Ser Ala Arg Asp Ser Glu Gln Val Ala Glu Leu Lys Gln 
705                 710                 715                 720 


Glu Leu Ala Thr Leu Lys Ser Gln Leu Asn Ser Gln Ser Val Glu Ile 
                725                 730                 735     


Thr Lys Leu Gln Thr Glu Lys Gln Glu Leu Leu Gln Lys Thr Glu Ala 
            740                 745                 750         


Phe Ala Lys Ser Val Glu Val Gln Gly Glu Thr Glu Thr Ile Ile Ala 
        755                 760                 765             


Thr Lys Thr Thr Asp Val Glu Gly Arg Leu Ser Ala Leu Leu Gln Glu 
    770                 775                 780                 


Thr Lys Glu Leu Lys Asn Glu Ile Lys Ala Leu Ser Glu Glu Arg Thr 
785                 790                 795                 800 


Ala Ile Lys Glu Gln Leu Asp Ser Ser Asn Ser Thr Ile Ala Ile Leu 
                805                 810                 815     


Gln Thr Glu Lys Asp Lys Leu Glu Leu Glu Ile Thr Asp Ser Lys Lys 
            820                 825                 830         


Glu Gln Asp Asp Leu Leu Val Leu Leu Ala Asp Gln Asp Gln Lys Ile 
        835                 840                 845             


Leu Ser Leu Lys Asn Lys Leu Lys Asp Leu Gly His Pro Val Glu Glu 
    850                 855                 860                 


Glu Asp Glu Leu Glu Ser Gly Asp Gln Glu Asp Glu Asp Asp Glu Ser 
865                 870                 875                 880 


Glu Asp Pro Gly Lys Asp Leu Asp His Ile 
                885                 890 


<210> 4962
<211> 647
<212> PRT
<213> Homo sapiens

<400> 4962
Met Ala Arg Ala Gly Pro Arg Leu Val Leu Ser Glu Glu Ala Val Arg 
1               5                   10                  15      


Ala Lys Ser Gly Leu Gly Pro His Arg Asp Leu Ala Glu Leu Gln Ser 
            20                  25                  30          


Leu Ser Ile Pro Gly Thr Tyr Gln Glu Lys Ile Thr His Leu Gly His 
        35                  40                  45              


Ser Leu Met Ser Leu Thr Gly Leu Lys Ser Leu Asp Leu Ser Arg Asn 
    50                  55                  60                  


Ser Leu Val Ser Leu Glu Gly Ile Gln Tyr Leu Thr Ala Leu Glu Ser 
65                  70                  75                  80  


Leu Asn Leu Tyr Tyr Asn Cys Ile Ser Ser Leu Ala Glu Val Phe Arg 
                85                  90                  95      


Leu His Ala Leu Thr Glu Leu Val Asp Val Asp Phe Arg Leu Asn Pro 
            100                 105                 110         


Val Val Lys Val Glu Pro Asp Tyr Arg Leu Phe Val Val His Leu Leu 
        115                 120                 125             


Pro Lys Leu Gln Gln Leu Asp Asp Arg Pro Val Arg Ala Ser Glu Arg 
    130                 135                 140                 


Lys Ala Ser Arg Leu His Phe Ala Ser Glu Asp Ser Leu Asp Ser Lys 
145                 150                 155                 160 


Glu Ser Val Pro Ala Ser Leu Lys Glu Gly Arg Pro His His Pro Arg 
                165                 170                 175     


Ala Lys Cys Thr Glu Ala Leu Ala Lys Gln Ser Leu Val Met Asp Ala 
            180                 185                 190         


Asp Asp Glu Ala Val Leu Asn Leu Ile Ala Glu Cys Glu Trp Asp Leu 
        195                 200                 205             


Gly Arg Pro Pro Gly Ser Thr Ser Phe Ser Gln Lys Gly Arg Glu Ala 
    210                 215                 220                 


Asp Ser Arg Gly Ser Gln Glu Ser Arg His Leu Leu Ser Pro Gln Leu 
225                 230                 235                 240 


Val Gln Tyr Gln Cys Gly Asp Ser Gly Lys Gln Gly Arg Glu Thr Arg 
                245                 250                 255     


Arg Ser Ser Cys Arg Gly Cys Cys Leu Glu Lys Met Pro Trp Ser Gln 
            260                 265                 270         


Leu Cys Gly Glu Leu Pro Pro Leu Tyr Gly Ala Glu Pro Glu Ala Ser 
        275                 280                 285             


Arg Ala Pro Arg Pro His Thr Tyr Phe Thr Pro His Pro Asp Ser Met 
    290                 295                 300                 


Asp Thr Glu Asp Ser Ala Ser Ser Gln Lys Leu Asp Leu Ser Gly Glu 
305                 310                 315                 320 


Met Val Pro Gly Pro Leu Pro Ala Pro Gly Lys Cys Arg Lys Arg Arg 
                325                 330                 335     


Met Pro Val Gly Arg Phe Gln Thr Phe Ser Asp Gln Glu Gly Leu Gly 
            340                 345                 350         


Cys Pro Glu Arg Thr His Gly Ser Ser Val Pro Lys Glu Ser Leu Ser 
        355                 360                 365             


Arg Gln Asp Ser Ser Glu Ser Arg Asn Gly Arg Thr Leu Ser Gln Pro 
    370                 375                 380                 


Glu Ala Ser Glu Thr Glu Glu Gln Arg Ser Arg Gly Val Thr Asp Thr 
385                 390                 395                 400 


Arg Glu Pro Ser Pro Gly Ser His Ser Ala Leu Pro Gly Lys Lys Thr 
                405                 410                 415     


Ala Leu Gln Ala Ala Leu Leu Glu Thr Leu Leu Asp Leu Val Asp Arg 
            420                 425                 430         


Ser Trp Gly Gly Cys Arg Ser Leu His Ser Asn Glu Ala Phe Leu Ala 
        435                 440                 445             


Gln Ala Arg His Ile Leu Ser Ser Val Glu Glu Phe Thr Ala Ala Gln 
    450                 455                 460                 


Asp Ser Ser Ala Met Val Gly Glu Asp Val Gly Ser Leu Ala Leu Glu 
465                 470                 475                 480 


Ser Lys Ser Leu Gln Ser Arg Leu Ala Glu Gln Gln Gln Gln His Ala 
                485                 490                 495     


Arg Glu Met Ser Glu Val Thr Ala Glu Leu His His Thr His Lys Glu 
            500                 505                 510         


Leu Asp Asp Leu Arg Gln His Leu Asp Lys Ser Leu Glu Glu Asn Ser 
        515                 520                 525             


Arg Leu Lys Ser Leu Leu Leu Ser Met Lys Lys Glu Val Lys Ser Ala 
    530                 535                 540                 


Asp Thr Ala Ala Thr Leu Asn Leu Gln Ile Ala Gly Leu Gln Thr Ser 
545                 550                 555                 560 


Val Lys Arg Leu Cys Gly Glu Ile Val Glu Leu Lys Gln His Leu Glu 
                565                 570                 575     


His Tyr Asp Lys Ile Gln Glu Leu Thr Gln Met Leu Gln Glu Ser His 
            580                 585                 590         


Ser Ser Leu Val Ser Thr Asn Glu His Leu Leu Gln Glu Leu Ser Gln 
        595                 600                 605             


Val Arg Ala Gln His Arg Ala Glu Val Glu Gln Met His Trp Ser Tyr 
    610                 615                 620                 


Gln Glu Leu Lys Lys Thr Met Ala Leu Phe Pro His Ser Ser Ala Ser 
625                 630                 635                 640 


His Gly Gly Cys Gln Ala Cys 
                645         


<210> 4963
<211> 258
<212> PRT
<213> Homo sapiens

<400> 4963
Met Ala Glu Thr Glu Glu Arg Ser Leu Asp Asn Phe Phe Ala Lys Arg 
1               5                   10                  15      


Asp Lys Lys Lys Lys Lys Glu Arg Ser Asn Arg Ala Ala Ser Ala Ala 
            20                  25                  30          


Gly Ala Ala Gly Ser Ala Gly Gly Ser Ser Gly Ala Ala Gly Ala Ala 
        35                  40                  45              


Gly Gly Gly Ala Gly Ala Gly Thr Arg Pro Gly Asp Gly Gly Thr Ala 
    50                  55                  60                  


Ser Ala Gly Ala Ala Gly Pro Gly Ala Ala Thr Lys Ala Val Thr Lys 
65                  70                  75                  80  


Asp Glu Asp Glu Trp Lys Glu Leu Glu Gln Lys Glu Val Asp Tyr Ser 
                85                  90                  95      


Gly Leu Arg Val Gln Ala Met Gln Ile Ser Ser Glu Lys Glu Glu Asp 
            100                 105                 110         


Asp Asn Glu Lys Arg Gln Asp Pro Gly Asp Asn Trp Glu Glu Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Met Glu Lys Ser Ser Gly Pro Trp Asn Lys Thr 
    130                 135                 140                 


Ala Pro Val Gln Ala Pro Pro Ala Pro Val Ile Val Thr Glu Thr Pro 
145                 150                 155                 160 


Glu Pro Ala Met Thr Ser Gly Val Tyr Arg Pro Pro Gly Ala Arg Leu 
                165                 170                 175     


Thr Thr Thr Arg Lys Thr Pro Gln Gly Pro Pro Glu Ile Tyr Ser Asp 
            180                 185                 190         


Thr Gln Phe Pro Ser Leu Gln Ser Thr Ala Lys His Val Glu Ser Arg 
        195                 200                 205             


Lys Asp Lys Glu Met Glu Lys Ser Phe Glu Val Val Arg His Lys Asn 
    210                 215                 220                 


Arg Gly Arg Asp Glu Val Ser Lys Asn Gln Ala Leu Lys Leu Gln Leu 
225                 230                 235                 240 


Asp Asn Gln Tyr Ala Val Leu Glu Asn Gln Lys Ser Ser His Ser Gln 
                245                 250                 255     


Tyr Asn 
        


<210> 4964
<211> 358
<212> PRT
<213> Homo sapiens

<400> 4964
Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 
            20                  25                  30          


Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 
        35                  40                  45              


Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 
    50                  55                  60                  


Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 
65                  70                  75                  80  


Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 
                85                  90                  95      


Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 
            100                 105                 110         


Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 
        115                 120                 125             


Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 
    130                 135                 140                 


Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 
                165                 170                 175     


Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 
            180                 185                 190         


Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 
        195                 200                 205             


Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 
    210                 215                 220                 


Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 
225                 230                 235                 240 


Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 
                245                 250                 255     


Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 
            260                 265                 270         


Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 
        275                 280                 285             


Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 
    290                 295                 300                 


Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 
305                 310                 315                 320 


Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 
                325                 330                 335     


Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 
            340                 345                 350         


Asn Gly Leu Gln Gly Tyr 
        355             


<210> 4965
<211> 207
<212> PRT
<213> Homo sapiens

<400> 4965
Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys 
            20                  25                  30          


Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys 
        35                  40                  45              


Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly 
65                  70                  75                  80  


Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe 
                85                  90                  95      


Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro 
            100                 105                 110         


Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp 
        115                 120                 125             


Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr 
    130                 135                 140                 


Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile 
145                 150                 155                 160 


Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln 
                165                 170                 175     


Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu 
            180                 185                 190         


Asp Lys Asn Asp Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys 
        195                 200                 205         


<210> 4966
<211> 1074
<212> PRT
<213> Homo sapiens

<400> 4966
Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg 
1               5                   10                  15      


Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr 
            20                  25                  30          


His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln 
        35                  40                  45              


Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr 
    50                  55                  60                  


Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr 
65                  70                  75                  80  


Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala 
                85                  90                  95      


Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala 
            100                 105                 110         


His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser 
    130                 135                 140                 


Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr 
145                 150                 155                 160 


Tyr Gln Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln 
                165                 170                 175     


Pro Gln Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala 
            180                 185                 190         


Gly Tyr Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg 
        195                 200                 205             


Gln Val Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr 
    210                 215                 220                 


Phe Ser Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala 
225                 230                 235                 240 


Ala Thr Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr 
                245                 250                 255     


Ala Val Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val 
            260                 265                 270         


Tyr Ser Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys 
        275                 280                 285             


Gln Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr 
    290                 295                 300                 


Gly Thr Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys 
305                 310                 315                 320 


Pro Lys Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys 
                325                 330                 335     


Lys Ile Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly 
            340                 345                 350         


Gln Lys His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr 
        355                 360                 365             


Ser Ser Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys 
    370                 375                 380                 


Glu Leu Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His 
385                 390                 395                 400 


Ile Arg Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu 
                405                 410                 415     


Gly Lys Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr 
            420                 425                 430         


Ser Ser Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser 
        435                 440                 445             


Ile Ala Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser 
    450                 455                 460                 


Ser Met Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr 
465                 470                 475                 480 


Ser Asn Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys 
                485                 490                 495     


Thr Ser Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser 
            500                 505                 510         


Thr Gly Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser 
        515                 520                 525             


Thr Pro Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr 
    530                 535                 540                 


Val Ser Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp 
545                 550                 555                 560 


Val Gln Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu 
                565                 570                 575     


Gly Lys Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn 
            580                 585                 590         


Asp Pro Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu 
        595                 600                 605             


Gln Tyr Lys Lys Lys Val Asn Pro Asp Leu Gln Val Glu Val Lys Pro 
    610                 615                 620                 


Ser Ile Arg Ala Arg Lys Ile Gln Glu Glu Lys Met Arg Lys Gln Met 
625                 630                 635                 640 


Gln Lys Glu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg 
                645                 650                 655     


Met Glu Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu 
            660                 665                 670         


Glu Glu Gln His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly 
        675                 680                 685             


Tyr Pro His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro 
    690                 695                 700                 


Gly Met Pro Pro Gln Pro Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp 
705                 710                 715                 720 


Ser Ser Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro 
                725                 730                 735     


Thr Glu Glu Glu Leu Gln Ala Val Gln Lys Ile Val Ser Ile Thr Glu 
            740                 745                 750         


Arg Ala Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn 
        755                 760                 765             


Lys Asn Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala 
    770                 775                 780                 


Leu Lys Gly Val Leu Arg Val Gly Val Leu Ala Lys Gly Leu Leu Leu 
785                 790                 795                 800 


Arg Gly Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro 
                805                 810                 815     


Ser Lys Thr Leu Leu Ser Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu 
            820                 825                 830         


Ala Val Ile Ser Pro Glu Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu 
        835                 840                 845             


Ala Ala Ile Ile Leu Asn Ser Cys Val Glu Pro Lys Met Gln Val Thr 
    850                 855                 860                 


Ile Thr Leu Thr Ser Pro Ile Ile Arg Glu Glu Asn Met Arg Glu Gly 
865                 870                 875                 880 


Asp Val Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg 
                885                 890                 895     


Gln Lys Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe 
            900                 905                 910         


Gln Ala Arg Ala Asn Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile 
        915                 920                 925             


Leu Arg Asp Leu Cys Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser 
    930                 935                 940                 


Trp Ala Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser 
945                 950                 955                 960 


Pro Gln Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser 
                965                 970                 975     


Ser Gly Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu 
            980                 985                 990         


Lys Asp Pro Phe Asp Thr Leu Ala  Thr Met Thr Asp Gln  Gln Arg Glu 
        995                 1000                 1005             


Asp Ile  Thr Ser Ser Ala Gln  Phe Ala Leu Arg Leu  Leu Ala Phe 
    1010                 1015                 1020             


Arg Gln  Ile His Lys Val Leu  Gly Met Asp Pro Leu  Pro Gln Met 
    1025                 1030                 1035             


Ser Gln  Arg Phe Asn Ile His  Asn Asn Arg Lys Arg  Arg Arg Asp 
    1040                 1045                 1050             


Ser Asp  Gly Val Asp Gly Phe  Glu Ala Glu Gly Lys  Lys Asp Lys 
    1055                 1060                 1065             


Lys Asp  Tyr Asp Asn Phe 
    1070                 


<210> 4967
<211> 145
<212> PRT
<213> Homo sapiens

<400> 4967
Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
1               5                   10                  15      


Arg His Phe Asn Ala Pro Ser His Val Arg Arg Lys Ile Met Ser Ser 
            20                  25                  30          


Pro Leu Ser Lys Glu Leu Arg Gln Lys Tyr Asn Val Arg Ser Met Pro 
        35                  40                  45              


Ile Arg Lys Asp Asp Glu Val Gln Val Val Arg Gly His Tyr Lys Gly 
    50                  55                  60                  


Gln Gln Ile Gly Lys Val Val Gln Val Tyr Arg Lys Lys Tyr Val Ile 
65                  70                  75                  80  


Tyr Ile Glu Arg Val Gln Arg Glu Lys Ala Asn Gly Thr Thr Val His 
                85                  90                  95      


Val Gly Ile His Pro Ser Lys Val Val Ile Thr Arg Leu Lys Leu Asp 
            100                 105                 110         


Lys Asp Arg Lys Lys Ile Leu Glu Arg Lys Ala Lys Ser Arg Gln Val 
        115                 120                 125             


Gly Lys Glu Lys Gly Lys Tyr Lys Glu Glu Leu Ile Glu Lys Met Gln 
    130                 135                 140                 


Glu 
145 


<210> 4968
<211> 1058
<212> PRT
<213> Homo sapiens

<400> 4968
Met Glu Asp Gly Thr Pro Lys His Ile Ile Gln Met Thr Gly Phe Lys 
1               5                   10                  15      


Met Glu Glu Lys Glu Ala Leu Val Lys Leu Leu Leu Lys Leu Asp Cys 
            20                  25                  30          


Thr Phe Ile Lys Ser Glu Lys Tyr Lys Asn Cys Thr His Leu Ile Ala 
        35                  40                  45              


Glu Arg Leu Cys Lys Ser Glu Lys Phe Leu Ala Ala Cys Ala Ala Gly 
    50                  55                  60                  


Lys Trp Ile Leu Thr Lys Asp Tyr Ile Ile His Ser Ala Lys Ser Gly 
65                  70                  75                  80  


Arg Trp Leu Asp Glu Thr Thr Tyr Glu Trp Gly Tyr Lys Ile Glu Lys 
                85                  90                  95      


Asp Ser Arg Tyr Ser Pro Gln Met Gln Ser Ala Pro Lys Arg Trp Arg 
            100                 105                 110         


Glu Glu Leu Lys Arg Thr Gly Ala Pro Gly Ala Phe His Arg Trp Lys 
        115                 120                 125             


Val Val Leu Leu Val Arg Thr Asp Lys Arg Ser Asp Ser Leu Ile Arg 
    130                 135                 140                 


Val Leu Glu Ala Gly Lys Ala Asn Val Ile Leu Pro Lys Ser Ser Pro 
145                 150                 155                 160 


Ser Gly Ile Thr His Val Ile Ala Ser Asn Ala Arg Ile Lys Ala Glu 
                165                 170                 175     


Lys Glu Lys Asp Asn Phe Lys Ala Pro Phe Tyr Pro Ile Gln Tyr Leu 
            180                 185                 190         


Gly Asp Phe Leu Leu Glu Lys Glu Ile Gln Asn Asp Glu Asp Ser Gln 
        195                 200                 205             


Thr Asn Ser Val Trp Thr Glu His Ser Asn Glu Glu Thr Asn Lys Asp 
    210                 215                 220                 


Phe Arg Lys Asp Ala Gly Phe Leu Glu Met Lys Gly Ala Leu Arg Glu 
225                 230                 235                 240 


Thr Met Tyr Arg Thr Gln Lys Glu Met Gln Asn His Glu Asp Val Asn 
                245                 250                 255     


Val Gly Ser Ile Leu Ile Gln His His Lys Lys Glu Lys Phe Ser Gly 
            260                 265                 270         


Ser Ser Lys Asp Leu Lys Phe Val Lys Met Arg Asn Thr Phe Gly Ser 
        275                 280                 285             


His Thr Tyr Glu Asn Gln Lys Glu Ile Lys Lys Lys Asp Glu Asp Ile 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Leu Arg Arg Lys Arg Lys Lys Gly Lys Glu Ser 
305                 310                 315                 320 


Asn Cys Lys Lys Gly Val Glu His Glu Lys Ile Lys Ser Thr Leu Arg 
                325                 330                 335     


Arg His Ile Tyr Asn Arg Asp Gln Lys Glu Met Lys Asn Ser Ile Phe 
            340                 345                 350         


Ala Glu Tyr Ala Lys Glu Ser Lys Ala Met Ala Ile Lys Thr Asp Val 
        355                 360                 365             


Asp Val Val Glu Ile Lys Asn Thr Leu Arg Lys His Ile Tyr Arg Ala 
    370                 375                 380                 


Gln Ala Val Arg Tyr Asn Cys Ile Arg Ile Asp Lys Gln Pro Val Tyr 
385                 390                 395                 400 


Asn Val Glu Val Lys Asn Ala Glu Phe Pro Arg Gly Val Leu Asn Leu 
                405                 410                 415     


Ile Glu Ser Leu Ile Glu Gly His Phe Phe Lys Glu Ala Ile Glu Glu 
            420                 425                 430         


Leu Ser Thr Leu Gln Ala His Tyr Ile Pro Pro Val Cys Val Leu His 
        435                 440                 445             


Ala Leu Leu Glu Asn Val Leu Gln Asp Asn Ile Asp Thr Phe Ser Gly 
    450                 455                 460                 


Arg Tyr Phe His Ile Leu Ser Ala Leu Leu His Leu His Pro Pro Trp 
465                 470                 475                 480 


Lys Ser Pro Ala Met Ser Arg Tyr Tyr Leu Glu Leu Phe Gln Cys Pro 
                485                 490                 495     


Thr Cys Met Lys Gly Ala Trp Ser Leu Val Glu Val Leu Ile Arg Ser 
            500                 505                 510         


Cys Leu Phe Asn Glu Ser Phe Cys His Gln Ile Ser Glu Asn Ile Gly 
        515                 520                 525             


Ser Lys Val Leu His Leu Thr Leu Leu Lys Phe Phe Phe Asn Leu Ile 
    530                 535                 540                 


Glu Ser Glu Val Gln His Leu Ser Gln Lys Leu Tyr Asp Trp Ser Asp 
545                 550                 555                 560 


Ser Gln Asn Leu Lys Ile Thr Gly Lys Ala Met Leu Leu Glu Ile Phe 
                565                 570                 575     


Trp Ser Gly Ser Glu Thr Ser Gly Leu Leu Thr Lys Pro Val Asn Met 
            580                 585                 590         


Leu Leu Glu Trp Thr Ile Tyr Ser His Lys Glu Lys Phe Lys Ser Asn 
        595                 600                 605             


Asp Val Phe Lys His Glu Leu Ala Tyr Leu Leu Ala Gly Ile Leu Gly 
    610                 615                 620                 


Ala Ala Ile Asp Tyr Trp Ile Phe Leu Gly Leu Lys Met Gly Arg Asn 
625                 630                 635                 640 


Val Met Arg His Met Ser Asp Asp Leu Gly Ser Tyr Val Ser Leu Ser 
                645                 650                 655     


Cys Asp Asp Phe Ser Ser Gln Glu Leu Glu Ile Phe Ile Cys Ser Phe 
            660                 665                 670         


Ser Ser Ser Trp Leu Gln Met Phe Val Ala Glu Ala Val Phe Lys Lys 
        675                 680                 685             


Leu Cys Leu Gln Ser Ser Gly Ser Val Ser Ser Glu Pro Leu Ser Leu 
    690                 695                 700                 


Gln Lys Met Val Tyr Ser Tyr Leu Pro Ala Leu Gly Lys Thr Gly Val 
705                 710                 715                 720 


Leu Gly Ser Gly Lys Ile Gln Val Ser Lys Lys Ile Gly Gln Arg Pro 
                725                 730                 735     


Cys Phe Asp Ser Gln Arg Thr Leu Leu Met Leu Asn Gly Thr Lys Gln 
            740                 745                 750         


Lys Gln Val Glu Gly Leu Pro Glu Leu Leu Asp Leu Asn Leu Ala Lys 
        755                 760                 765             


Cys Ser Ser Ser Leu Lys Lys Leu Lys Lys Lys Ser Glu Gly Glu Leu 
    770                 775                 780                 


Ser Cys Ser Lys Glu Asn Cys Pro Ser Val Val Lys Lys Met Asn Phe 
785                 790                 795                 800 


His Lys Thr Asn Leu Lys Gly Glu Thr Ala Leu His Arg Ala Cys Ile 
                805                 810                 815     


Asn Asn Gln Val Glu Lys Leu Ile Leu Leu Leu Ser Leu Pro Gly Ile 
            820                 825                 830         


Asp Ile Asn Val Lys Asp Asn Ala Gly Trp Thr Pro Leu His Glu Ala 
        835                 840                 845             


Cys Asn Tyr Gly Asn Thr Val Cys Val Gln Glu Ile Leu Gln Arg Cys 
    850                 855                 860                 


Pro Glu Val Asp Leu Leu Thr Gln Val Asp Gly Val Thr Pro Leu His 
865                 870                 875                 880 


Asp Ala Leu Ser Asn Gly His Val Glu Ile Gly Lys Leu Leu Leu Gln 
                885                 890                 895     


His Gly Gly Pro Val Leu Leu Gln Gln Arg Asn Ala Lys Gly Glu Leu 
            900                 905                 910         


Pro Leu Asp Tyr Val Val Ser Pro Gln Ile Lys Glu Glu Leu Phe Ala 
        915                 920                 925             


Ile Thr Lys Ile Glu Asp Thr Val Glu Asn Phe His Ala Gln Ala Glu 
    930                 935                 940                 


Lys His Phe His Tyr Gln Gln Leu Glu Phe Gly Ser Phe Leu Leu Ser 
945                 950                 955                 960 


Arg Met Leu Leu Asn Phe Cys Ser Ile Phe Asp Leu Ser Ser Glu Phe 
                965                 970                 975     


Ile Leu Ala Ser Lys Gly Leu Thr His Leu Asn Glu Leu Leu Met Ala 
            980                 985                 990         


Cys Lys Ser His Lys Glu Thr Thr  Ser Val His Thr Asp  Trp Leu Leu 
        995                 1000                 1005             


Asp Leu  Tyr Ala Gly Asn Ile  Lys Thr Leu Gln Lys  Leu Pro His 
    1010                 1015                 1020             


Ile Leu  Lys Glu Leu Pro Glu  Asn Leu Lys Val Cys  Pro Gly Val 
    1025                 1030                 1035             


His Thr  Glu Ala Leu Met Ile  Thr Leu Glu Met Met  Cys Arg Ser 
    1040                 1045                 1050             


Val Met  Glu Phe Ser 
    1055             


<210> 4969
<211> 219
<212> PRT
<213> Homo sapiens

<400> 4969
Met Glu Pro Lys Glu Ala Thr Gly Lys Glu Asn Met Val Thr Lys Lys 
1               5                   10                  15      


Lys Asn Leu Ala Phe Leu Arg Ser Arg Leu Tyr Met Leu Glu Arg Arg 
            20                  25                  30          


Lys Thr Asp Thr Val Val Glu Ser Ser Val Ser Gly Asp His Ser Gly 
        35                  40                  45              


Thr Leu Arg Arg Ser Gln Ser Asp Arg Thr Glu Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Gln Glu Lys Met Thr Pro Gln Gly Glu Cys Ser Val Ala Glu Thr Leu 
65                  70                  75                  80  


Thr Pro Glu Glu Glu His His Met Lys Arg Met Met Ala Lys Arg Glu 
                85                  90                  95      


Lys Ile Ile Lys Glu Leu Ile Gln Thr Glu Lys Asp Tyr Leu Asn Asp 
            100                 105                 110         


Leu Glu Leu Cys Val Arg Glu Val Val Gln Pro Leu Arg Asn Lys Lys 
        115                 120                 125             


Thr Asp Arg Leu Asp Val Asp Ser Leu Phe Ser Asn Ile Glu Ser Val 
    130                 135                 140                 


His Gln Ile Ser Ala Lys Leu Leu Ser Leu Leu Glu Glu Ala Thr Thr 
145                 150                 155                 160 


Asp Val Glu Pro Ala Met Gln Val Ile Gly Glu Val Phe Leu Gln Ile 
                165                 170                 175     


Lys Gly Pro Leu Glu Asp Ile Tyr Lys Ile Tyr Cys Tyr His His Asp 
            180                 185                 190         


Glu Ala His Ser Ile Leu Glu Ser Tyr Glu Lys Glu Glu Glu Leu Lys 
        195                 200                 205             


Glu His Leu Ser His Cys Ile Gln Ser Leu Lys 
    210                 215                 


<210> 4970
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 4970
Met Leu Ile Glu Asp Val Asp Ala Leu Lys Ser Trp Leu Ala Lys Leu 
1               5                   10                  15      


Leu Glu Pro Ile Cys Asp Ala Asp Pro Ser Ala Leu Ala Asn Tyr Val 
            20                  25                  30          


Val Ala Leu Val Lys Lys Asp Lys Pro Glu Lys Glu Leu Lys Ala Phe 
        35                  40                  45              


Cys Ala Asp Gln Leu Asp Val Phe Leu Gln Lys Glu Thr Ser Gly Phe 
    50                  55                  60                  


Val Asp Lys Leu Phe Glu Ser Leu Tyr Thr Lys Asn Tyr Leu Pro Leu 
65                  70                  75                  80  


Leu Glu Pro Val Lys Pro Glu Pro Lys Pro Leu Val Gln Glu Lys Glu 
                85                  90                  95      


Glu Ile Lys Glu Glu Val Phe Gln Glu Pro Ala Glu Glu Glu Arg Asp 
            100                 105                 110         


Gly Arg Lys Lys Lys Tyr Pro Ser Pro Gln Lys Thr Arg Ser Glu Ser 
        115                 120                 125             


Ser Glu Arg Arg Thr Arg Glu Lys Lys Arg Glu Asp Gly Lys Trp Arg 
    130                 135                 140                 


Asp Tyr Asp Arg Tyr Tyr Glu Arg Asn Glu Leu Tyr Arg Glu Lys Tyr 
145                 150                 155                 160 


Asp Trp Arg Arg Gly Arg Ser Lys Ser Arg Ser Lys Ser Arg Gly Leu 
                165                 170                 175     


Ser Arg Ser Arg Ser Arg Ser Arg Gly Arg Ser Lys Asp Arg Asp Pro 
            180                 185                 190         


Asn Arg Asn Val Glu His Arg Glu Arg Ser Lys Phe Lys Ser Glu Arg 
        195                 200                 205             


Asn Asp Leu Glu Ser Ser Tyr Val Pro Val Ser Ala Pro Pro Pro Asn 
    210                 215                 220                 


Ser Ser Glu Gln Tyr Ser Ser Gly Ala Gln Ser Ile Pro Ser Thr Val 
225                 230                 235                 240 


Thr Val Ile Ala Pro Ala His His Ser Glu Asn Thr Thr Glu Ser Trp 
                245                 250                 255     


Ser Asn Tyr Tyr Asn Asn His Ser Ser Ser Asn Ser Phe Gly Arg Asn 
            260                 265                 270         


Leu Pro Pro Lys Arg Arg Cys Arg Asp Tyr Asp Glu Arg Gly Phe Cys 
        275                 280                 285             


Val Leu Gly Asp Leu Cys Gln Phe Asp His Gly Asn Asp Pro Leu Val 
    290                 295                 300                 


Val Asp Glu Val Ala Leu Pro Ser Met Ile Pro Phe Pro Pro Pro Pro 
305                 310                 315                 320 


Pro Gly Leu Pro Pro Pro Pro Pro Pro Gly Met Leu Met Pro Pro Met 
                325                 330                 335     


Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly 
            340                 345                 350         


Pro Gly Pro Gly Pro Gly His Ser Met Arg Leu Pro Val Pro Gln Gly 
        355                 360                 365             


His Gly Gln Pro Pro Pro Ser Val Val Leu Pro Ile Pro Arg Pro Pro 
    370                 375                 380                 


Ile Thr Gln Ser Ser Leu Ile Asn Ser Arg Asp Gln Pro Gly Thr Ser 
385                 390                 395                 400 


Ala Val Pro Asn Leu Ala Ser Val Gly Thr Arg Leu Pro Pro Pro Leu 
                405                 410                 415     


Pro Gln Asn Leu Leu Tyr Thr Val Ser Glu Arg Gln Pro Met Tyr Ser 
            420                 425                 430         


Arg Glu His Gly Ala Ala Ala Ser Glu Arg Leu Gln Leu Gly Thr Pro 
        435                 440                 445             


Pro Pro Leu Leu Ala Ala Arg Leu Val Pro Pro Arg Asn Leu Met Gly 
    450                 455                 460                 


Ser Ser Ile Gly Tyr His Thr Ser Val Ser Ser Pro Thr Pro Leu Val 
465                 470                 475                 480 


Pro Asp Thr Tyr Glu Pro Asp Gly Tyr Asn Pro Glu Ala Pro Ser Ile 
                485                 490                 495     


Thr Ser Ser Gly Arg Ser Gln Tyr Arg Gln Phe Phe Ser Arg Thr Gln 
            500                 505                 510         


Thr Gln Arg Pro Asn Leu Ile Gly Leu Thr Ser Gly Asp Met Asp Val 
        515                 520                 525             


Asn Pro Arg Ala Ala Asn Ile Val Ile Gln Thr Glu Pro Pro Val Pro 
    530                 535                 540                 


Val Ser Ile Asn Ser Asn Ile Thr Arg Val Val Leu Glu Pro Asp Ser 
545                 550                 555                 560 


Arg Lys Arg Ala Met Ser Gly Leu Glu Gly Pro Leu Thr Lys Lys Pro 
                565                 570                 575     


Trp Leu Gly Lys Gln Gly Asn Asn Asn Gln Asn Lys Pro Gly Phe Leu 
            580                 585                 590         


Arg Lys Asn Gln Tyr Thr Asn Thr Lys Leu Glu Val Lys Lys Ile Pro 
        595                 600                 605             


Gln Glu Leu Asn Asn Ile Thr Lys Leu Asn Glu His Phe Ser Lys Phe 
    610                 615                 620                 


Gly Thr Ile Val Asn Ile Gln Val Ala Phe Lys Gly Asp Pro Glu Ala 
625                 630                 635                 640 


Ala Leu Ile Gln Tyr Leu Thr Asn Glu Glu Ala Arg Lys Ala Ile Ser 
                645                 650                 655     


Ser Thr Glu Ala Val Leu Asn Asn Arg Phe Ile Arg Val Leu Trp His 
            660                 665                 670         


Arg Glu Asn Asn Glu Gln Pro Thr Leu Gln Ser Ser Ala Gln Leu Leu 
        675                 680                 685             


Leu Gln Gln Gln Gln Thr Leu Ser His Leu Ser Gln Gln His His His 
    690                 695                 700                 


Leu Pro Gln His Leu His Gln Gln Gln Val Leu Val Ala Gln Ser Ala 
705                 710                 715                 720 


Pro Ser Thr Val His Gly Gly Ile Gln Lys Met Met Ser Lys Pro Gln 
                725                 730                 735     


Thr Ser Gly Ala Tyr Val Leu Asn Lys Val Pro Val Lys His Arg Leu 
            740                 745                 750         


Gly His Ala Gly Gly Asn Gln Ser Asp Ala Ser His Leu Leu Asn Gln 
        755                 760                 765             


Ser Gly Gly Ala Gly Glu Asp Cys Gln Ile Phe Ser Thr Pro Gly His 
    770                 775                 780                 


Pro Lys Met Ile Tyr Ser Ser Ser Asn Leu Lys Thr Pro Ser Lys Leu 
785                 790                 795                 800 


Cys Ser Gly Ser Lys Ser His Asp Val Gln Glu Val Leu Lys Lys Lys 
                805                 810                 815     


Gln Glu Ala Met Lys Leu Gln Gln Asp Met Arg Lys Lys Arg Gln Glu 
            820                 825                 830         


Val Leu Glu Lys Gln Ile Glu Cys Gln Lys Met Leu Ile Ser Lys Leu 
        835                 840                 845             


Glu Lys Asn Lys Asn Met Lys Pro Glu Glu Arg Ala Asn Ile Met Lys 
    850                 855                 860                 


Thr Leu Lys Glu Leu Gly Glu Lys Ile Ser Gln Leu Lys Asp Glu Leu 
865                 870                 875                 880 


Lys Thr Ser Ser Ala Val Ser Thr Pro Ser Lys Val Lys Thr Lys Thr 
                885                 890                 895     


Glu Ala Gln Lys Glu Leu Leu Asp Thr Glu Leu Asp Leu His Lys Arg 
            900                 905                 910         


Leu Ser Ser Gly Glu Asp Thr Thr Glu Leu Arg Lys Lys Leu Ser Gln 
        915                 920                 925             


Leu Gln Val Glu Ala Ala Arg Leu Gly Ile Leu Pro Val Gly Arg Gly 
    930                 935                 940                 


Lys Thr Met Ser Ser Gln Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly 
945                 950                 955                 960 


Arg Gly Arg Gly Ser Leu Asn His Met Val Val Asp His Arg Pro Lys 
                965                 970                 975     


Ala Leu Thr Val Gly Gly Phe Ile Glu Glu Glu Lys Glu Asp Leu Leu 
            980                 985                 990         


Gln His Phe Ser Thr Ala Asn Gln  Gly Pro Lys Phe Lys  Asp Arg Arg 
        995                 1000                 1005             


Leu Gln  Ile Ser Trp His Lys  Pro Lys Val Pro Ser  Ile Ser Thr 
    1010                 1015                 1020             


Glu Thr  Glu Glu Glu Glu Val  Lys Glu Glu Glu Thr  Glu Thr Ser 
    1025                 1030                 1035             


Asp Leu  Phe Leu Pro Asp Asp  Asp Asp Glu Asp Glu  Asp Glu Tyr 
    1040                 1045                 1050             


Glu Ser  Arg Ser Trp Arg Arg  
    1055                 1060 


<210> 4971
<211> 605
<212> PRT
<213> Homo sapiens

<400> 4971
Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys Met His Leu Glu Lys Leu Glu Glu 
                85                  90                  95      


Gln Leu Ser Arg Ser His Gly Gln Glu Val Asn Glu Leu Lys Thr Lys 
            100                 105                 110         


Ile Glu Lys Leu Lys Val Glu Leu Asp Glu Ala Arg Leu Ser Glu Lys 
        115                 120                 125             


Gln Leu Lys His Gln Val Asp His Gln Lys Glu Leu Leu Ser Cys Lys 
    130                 135                 140                 


Ser Glu Glu Leu Arg Val Met Ser Glu Arg Val Gln Glu Ser Met Ser 
145                 150                 155                 160 


Ser Glu Met Leu Ala Leu Gln Ile Glu Leu Thr Glu Met Glu Ser Met 
                165                 170                 175     


Lys Thr Thr Leu Lys Glu Glu Val Asn Glu Leu Gln Tyr Arg Gln Glu 
            180                 185                 190         


Gln Leu Glu Leu Leu Ile Thr Asn Leu Met Arg Gln Val Asp Arg Leu 
        195                 200                 205             


Lys Glu Glu Lys Glu Glu Arg Glu Lys Glu Ala Val Ser Tyr Tyr Asn 
    210                 215                 220                 


Ala Leu Glu Lys Ala Arg Val Ala Asn Gln Asp Leu Gln Val Gln Leu 
225                 230                 235                 240 


Asp Gln Ala Leu Gln Gln Ala Leu Asp Pro Asn Ser Lys Gly Asn Ser 
                245                 250                 255     


Leu Phe Ala Glu Val Glu Asp Arg Arg Ala Ala Met Glu Arg Gln Leu 
            260                 265                 270         


Ile Ser Met Lys Val Lys Tyr Gln Ser Leu Lys Lys Gln Asn Val Phe 
        275                 280                 285             


Asn Arg Glu Gln Met Gln Arg Met Lys Leu Gln Ile Ala Thr Leu Leu 
    290                 295                 300                 


Gln Met Lys Gly Ser Gln Thr Glu Phe Glu Gln Gln Glu Arg Leu Leu 
305                 310                 315                 320 


Ala Met Leu Glu Gln Lys Asn Gly Glu Ile Lys His Leu Leu Gly Glu 
                325                 330                 335     


Ile Arg Asn Leu Glu Lys Phe Lys Asn Leu Tyr Asp Ser Met Glu Ser 
            340                 345                 350         


Lys Pro Ser Val Asp Ser Gly Thr Leu Glu Asp Asn Thr Tyr Tyr Thr 
        355                 360                 365             


Asp Leu Leu Gln Met Lys Leu Asp Asn Leu Asn Lys Glu Ile Glu Ser 
    370                 375                 380                 


Thr Lys Gly Glu Leu Ser Ile Gln Arg Met Lys Ala Leu Phe Glu Ser 
385                 390                 395                 400 


Gln Arg Ala Leu Asp Ile Glu Arg Lys Leu Phe Ala Asn Glu Arg Cys 
                405                 410                 415     


Leu Gln Leu Ser Glu Ser Glu Asn Met Lys Leu Arg Ala Lys Leu Asp 
            420                 425                 430         


Glu Leu Lys Leu Lys Tyr Glu Pro Glu Glu Thr Val Glu Val Pro Val 
        435                 440                 445             


Leu Lys Lys Arg Arg Glu Val Leu Pro Val Asp Ile Thr Thr Ala Lys 
    450                 455                 460                 


Asp Ala Cys Val Asn Asn Ser Ala Leu Gly Gly Glu Val Tyr Arg Leu 
465                 470                 475                 480 


Pro Pro Gln Lys Glu Glu Thr Gln Ser Cys Pro Asn Ser Leu Glu Asp 
                485                 490                 495     


Asn Asn Leu Gln Leu Glu Lys Ser Val Ser Ile Tyr Thr Pro Val Val 
            500                 505                 510         


Ser Leu Ser Pro His Lys Asn Leu Pro Val Asp Met Gln Leu Lys Lys 
        515                 520                 525             


Glu Lys Lys Cys Val Lys Leu Ile Gly Val Pro Ala Asp Ala Glu Ala 
    530                 535                 540                 


Leu Ser Glu Arg Ser Gly Asn Thr Pro Asn Ser Pro Arg Leu Ala Ala 
545                 550                 555                 560 


Glu Ser Lys Leu Gln Thr Glu Val Lys Glu Gly Lys Glu Thr Ser Ser 
                565                 570                 575     


Lys Leu Glu Lys Glu Thr Cys Lys Lys Leu His Pro Ile Leu Tyr Val 
            580                 585                 590         


Ser Ser Lys Ser Thr Pro Glu Thr Gln Cys Pro Gln Gln 
        595                 600                 605 


<210> 4972
<211> 295
<212> PRT
<213> Homo sapiens

<400> 4972
Met Met Ala Lys Lys Pro Pro Lys Pro Ala Pro Arg Arg Ile Phe Gln 
1               5                   10                  15      


Glu Arg Leu Lys Ile Thr Ala Leu Pro Leu Tyr Phe Glu Gly Phe Leu 
            20                  25                  30          


Leu Ile Lys Arg Ser Gly Tyr Arg Glu Tyr Glu His Tyr Trp Thr Glu 
        35                  40                  45              


Leu Arg Gly Thr Thr Leu Phe Phe Tyr Thr Asp Lys Lys Ser Ile Ile 
    50                  55                  60                  


Tyr Val Asp Lys Leu Asp Ile Val Asp Leu Thr Cys Leu Thr Glu Gln 
65                  70                  75                  80  


Asn Ser Thr Glu Lys Asn Cys Ala Lys Phe Thr Leu Val Leu Pro Lys 
                85                  90                  95      


Glu Glu Val Gln Leu Lys Thr Glu Asn Thr Glu Ser Gly Glu Glu Trp 
            100                 105                 110         


Arg Gly Phe Ile Leu Thr Val Thr Glu Leu Ser Val Pro Gln Asn Val 
        115                 120                 125             


Ser Leu Leu Pro Gly Gln Val Ile Lys Leu His Glu Val Leu Glu Arg 
    130                 135                 140                 


Glu Lys Lys Arg Arg Ile Glu Thr Glu Gln Ser Thr Ser Val Glu Lys 
145                 150                 155                 160 


Glu Lys Glu Pro Thr Glu Asp Tyr Val Asp Val Leu Asn Pro Met Pro 
                165                 170                 175     


Ala Cys Phe Tyr Thr Val Ser Arg Lys Glu Ala Thr Glu Met Leu Gln 
            180                 185                 190         


Lys Asn Pro Ser Leu Gly Asn Met Ile Leu Arg Pro Gly Ser Asp Ser 
        195                 200                 205             


Arg Asn Tyr Ser Ile Thr Ile Arg Gln Glu Ile Asp Ile Pro Arg Ile 
    210                 215                 220                 


Lys His Tyr Lys Val Met Ser Val Gly Gln Asn Tyr Thr Ile Glu Leu 
225                 230                 235                 240 


Glu Lys Pro Val Thr Leu Pro Asn Leu Phe Ser Val Ile Asp Tyr Phe 
                245                 250                 255     


Val Lys Glu Thr Arg Gly Asn Leu Arg Pro Phe Ile Cys Ser Thr Asp 
            260                 265                 270         


Glu Asn Thr Gly Gln Glu Pro Ser Met Glu Gly Arg Ser Glu Lys Leu 
        275                 280                 285             


Lys Lys Asn Pro His Ile Ala 
    290                 295 


<210> 4973
<211> 1606
<212> PRT
<213> Homo sapiens

<400> 4973
Met Phe His Ile Cys Pro Ala Glu Asn Leu Tyr Gln Asn Arg Phe Leu 
1               5                   10                  15      


Gly Leu Ala Ala Met Ala Ser Pro Ser Arg Asn Ser Gln Ser Arg Arg 
            20                  25                  30          


Arg Cys Lys Glu Pro Leu Arg Tyr Ser Tyr Asn Pro Asp Gln Phe His 
        35                  40                  45              


Asn Met Asp Leu Arg Gly Gly Pro His Asp Gly Val Thr Ile Pro Arg 
    50                  55                  60                  


Ser Thr Ser Asp Thr Asp Leu Val Thr Ser Asp Ser Arg Ser Thr Leu 
65                  70                  75                  80  


Met Val Ser Ser Ser Tyr Tyr Ser Ile Gly His Ser Gln Asp Leu Val 
                85                  90                  95      


Ile His Trp Asp Ile Lys Glu Glu Val Asp Ala Gly Asp Trp Ile Gly 
            100                 105                 110         


Met Tyr Leu Ile Asp Glu Val Leu Ser Glu Asn Phe Leu Asp Tyr Lys 
        115                 120                 125             


Asn Arg Gly Val Asn Gly Ser His Arg Gly Gln Ile Ile Trp Lys Ile 
    130                 135                 140                 


Asp Ala Ser Ser Tyr Phe Val Glu Pro Glu Thr Lys Ile Cys Phe Lys 
145                 150                 155                 160 


Tyr Tyr His Gly Val Ser Gly Ala Leu Arg Ala Thr Thr Pro Ser Val 
                165                 170                 175     


Thr Val Lys Asn Ser Ala Ala Pro Ile Phe Lys Ser Ile Gly Ala Asp 
            180                 185                 190         


Glu Thr Val Gln Gly Gln Gly Ser Arg Arg Leu Ile Ser Phe Ser Leu 
        195                 200                 205             


Ser Asp Phe Gln Ala Met Gly Leu Lys Lys Gly Met Phe Phe Asn Pro 
    210                 215                 220                 


Asp Pro Tyr Leu Lys Ile Ser Ile Gln Pro Gly Lys His Ser Ile Phe 
225                 230                 235                 240 


Pro Ala Leu Pro His His Gly Gln Glu Arg Arg Ser Lys Ile Ile Gly 
                245                 250                 255     


Asn Thr Val Asn Pro Ile Trp Gln Ala Glu Gln Phe Ser Phe Val Ser 
            260                 265                 270         


Leu Pro Thr Asp Val Leu Glu Ile Glu Val Lys Asp Lys Phe Ala Lys 
        275                 280                 285             


Ser Arg Pro Ile Ile Lys Arg Phe Leu Gly Lys Leu Ser Met Pro Val 
    290                 295                 300                 


Gln Arg Leu Leu Glu Arg His Ala Ile Gly Asp Arg Val Val Ser Tyr 
305                 310                 315                 320 


Thr Leu Gly Arg Arg Leu Pro Thr Asp His Val Ser Gly Gln Leu Gln 
                325                 330                 335     


Phe Arg Phe Glu Ile Thr Ser Ser Ile His Pro Ala Asp Asp Glu Glu 
            340                 345                 350         


Ile Ser Leu Ser Thr Glu Pro Glu Ser Ala Gln Ile Gln Asp Ser Pro 
        355                 360                 365             


Met Asn Asn Leu Met Glu Ser Gly Ser Gly Glu Pro Arg Ser Glu Ala 
    370                 375                 380                 


Pro Glu Ser Ser Glu Ser Trp Lys Pro Glu Gln Leu Gly Glu Gly Ser 
385                 390                 395                 400 


Val Pro Asp Gly Pro Gly Asn Gln Ser Ile Glu Leu Ser Arg Pro Ala 
                405                 410                 415     


Glu Glu Ala Ala Val Ile Thr Glu Ala Gly Asp Gln Gly Met Val Ser 
            420                 425                 430         


Val Gly Pro Glu Gly Ala Gly Glu Leu Leu Ala Gln Val Gln Lys Asp 
        435                 440                 445             


Ile Gln Pro Ala Pro Ser Ala Glu Glu Leu Ala Glu Gln Leu Asp Leu 
    450                 455                 460                 


Gly Glu Glu Ala Ser Ala Leu Leu Leu Glu Asp Gly Glu Ala Pro Ala 
465                 470                 475                 480 


Ser Thr Lys Glu Glu Pro Leu Glu Glu Glu Ala Thr Thr Gln Ser Arg 
                485                 490                 495     


Ala Gly Arg Glu Glu Glu Glu Lys Glu Gln Glu Glu Glu Gly Asp Val 
            500                 505                 510         


Ser Thr Leu Glu Gln Gly Glu Gly Arg Leu Gln Leu Arg Ala Ser Val 
        515                 520                 525             


Lys Arg Lys Ser Arg Pro Cys Ser Leu Pro Val Ser Glu Leu Glu Thr 
    530                 535                 540                 


Val Ile Ala Ser Ala Cys Gly Asp Pro Glu Thr Pro Arg Thr His Tyr 
545                 550                 555                 560 


Ile Arg Ile His Thr Leu Leu His Ser Met Pro Ser Ala Gln Gly Gly 
                565                 570                 575     


Ser Ala Ala Glu Glu Glu Asp Gly Ala Glu Glu Glu Ser Thr Leu Lys 
            580                 585                 590         


Asp Ser Ser Glu Lys Asp Gly Leu Ser Glu Val Asp Thr Val Ala Ala 
        595                 600                 605             


Asp Pro Ser Ala Leu Glu Glu Asp Arg Glu Glu Pro Glu Gly Ala Thr 
    610                 615                 620                 


Pro Gly Thr Ala His Pro Gly His Ser Gly Gly His Phe Pro Ser Leu 
625                 630                 635                 640 


Ala Asn Gly Ala Ala Gln Asp Gly Asp Thr His Pro Ser Thr Gly Ser 
                645                 650                 655     


Glu Ser Asp Ser Ser Pro Arg Gln Gly Gly Asp His Ser Cys Glu Gly 
            660                 665                 670         


Cys Asp Ala Ser Cys Cys Ser Pro Ser Cys Tyr Ser Ser Ser Cys Tyr 
        675                 680                 685             


Ser Thr Ser Cys Tyr Ser Ser Ser Cys Tyr Ser Ala Ser Cys Tyr Ser 
    690                 695                 700                 


Pro Ser Cys Tyr Asn Gly Asn Arg Phe Ala Ser His Thr Arg Phe Ser 
705                 710                 715                 720 


Ser Val Asp Ser Ala Lys Ile Ser Glu Ser Thr Val Phe Ser Ser Gln 
                725                 730                 735     


Asp Asp Glu Glu Glu Glu Asn Ser Ala Phe Glu Ser Val Pro Asp Ser 
            740                 745                 750         


Met Gln Ser Pro Glu Leu Asp Pro Glu Ser Thr Asn Gly Ala Gly Pro 
        755                 760                 765             


Trp Gln Asp Glu Leu Ala Ala Pro Ser Gly His Val Glu Arg Ser Pro 
    770                 775                 780                 


Glu Gly Leu Glu Ser Pro Val Ala Gly Pro Ser Asn Arg Arg Glu Gly 
785                 790                 795                 800 


Glu Cys Pro Ile Leu His Asn Ser Gln Pro Val Ser Gln Leu Pro Ser 
                805                 810                 815     


Leu Arg Pro Glu His His His Tyr Pro Thr Ile Asp Glu Pro Leu Pro 
            820                 825                 830         


Pro Asn Trp Glu Ala Arg Ile Asp Ser His Gly Arg Val Phe Tyr Val 
        835                 840                 845             


Asp His Val Asn Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Ala Ala 
    850                 855                 860                 


Thr Pro Asp Gly Met Arg Arg Ser Gly Ser Ile Gln Gln Met Glu Gln 
865                 870                 875                 880 


Leu Asn Arg Arg Tyr Gln Asn Ile Gln Arg Thr Ile Ala Thr Glu Arg 
                885                 890                 895     


Ser Glu Glu Asp Ser Gly Ser Gln Ser Cys Glu Gln Ala Pro Ala Gly 
            900                 905                 910         


Gly Gly Gly Gly Gly Gly Ser Asp Ser Glu Ala Glu Ser Ser Gln Ser 
        915                 920                 925             


Ser Leu Asp Leu Arg Arg Glu Gly Ser Leu Ser Pro Val Asn Ser Gln 
    930                 935                 940                 


Lys Ile Thr Leu Leu Leu Gln Ser Pro Ala Val Lys Phe Ile Thr Asn 
945                 950                 955                 960 


Pro Glu Phe Phe Thr Val Leu His Ala Asn Tyr Ser Ala Tyr Arg Val 
                965                 970                 975     


Phe Thr Ser Ser Thr Cys Leu Lys His Met Ile Leu Lys Val Arg Arg 
            980                 985                 990         


Asp Ala Arg Asn Phe Glu Arg Tyr  Gln His Asn Arg Asp  Leu Val Asn 
        995                 1000                 1005             


Phe Ile  Asn Met Phe Ala Asp  Thr Arg Leu Glu Leu  Pro Arg Gly 
    1010                 1015                 1020             


Trp Glu  Ile Lys Thr Asp Gln  Gln Gly Lys Ser Phe  Phe Val Asp 
    1025                 1030                 1035             


His Asn  Ser Arg Ala Thr Thr  Phe Ile Asp Pro Arg  Ile Pro Leu 
    1040                 1045                 1050             


Gln Asn  Gly Arg Leu Pro Asn  His Leu Thr His Arg  Gln His Leu 
    1055                 1060                 1065             


Gln Arg  Leu Arg Ser Tyr Ser  Ala Gly Glu Ala Ser  Glu Val Ser 
    1070                 1075                 1080             


Arg Asn  Arg Gly Ala Ser Leu  Leu Ala Arg Pro Gly  His Ser Leu 
    1085                 1090                 1095             


Val Ala  Ala Ile Arg Ser Gln  His Gln His Glu Ser  Leu Pro Leu 
    1100                 1105                 1110             


Ala Tyr  Asn Asp Lys Ile Val  Ala Phe Leu Arg Gln  Pro Asn Ile 
    1115                 1120                 1125             


Phe Glu  Met Leu Gln Glu Arg  Gln Pro Ser Leu Ala  Arg Asn His 
    1130                 1135                 1140             


Thr Leu  Arg Glu Lys Ile His  Tyr Ile Arg Thr Glu  Gly Asn His 
    1145                 1150                 1155             


Gly Leu  Glu Lys Leu Ser Cys  Asp Ala Asp Leu Val  Ile Leu Leu 
    1160                 1165                 1170             


Ser Leu  Phe Glu Glu Glu Ile  Met Ser Tyr Val Pro  Leu Gln Ala 
    1175                 1180                 1185             


Ala Phe  His Pro Gly Tyr Ser  Phe Ser Pro Arg Cys  Ser Pro Cys 
    1190                 1195                 1200             


Ser Ser  Pro Gln Asn Ser Pro  Gly Leu Gln Arg Ala  Ser Ala Arg 
    1205                 1210                 1215             


Ala Pro  Ser Pro Tyr Arg Arg  Asp Phe Glu Ala Lys  Leu Arg Asn 
    1220                 1225                 1230             


Phe Tyr  Arg Lys Leu Glu Ala  Lys Gly Phe Gly Gln  Gly Pro Gly 
    1235                 1240                 1245             


Lys Ile  Lys Leu Ile Ile Arg  Arg Asp His Leu Leu  Glu Gly Thr 
    1250                 1255                 1260             


Phe Asn  Gln Val Met Ala Tyr  Ser Arg Lys Glu Leu  Gln Arg Asn 
    1265                 1270                 1275             


Lys Leu  Tyr Val Thr Phe Val  Gly Glu Glu Gly Leu  Asp Tyr Ser 
    1280                 1285                 1290             


Gly Pro  Ser Arg Glu Phe Phe  Phe Leu Leu Ser Gln  Glu Leu Phe 
    1295                 1300                 1305             


Asn Pro  Tyr Tyr Gly Leu Phe  Glu Tyr Ser Ala Asn  Asp Thr Tyr 
    1310                 1315                 1320             


Thr Val  Gln Ile Ser Pro Met  Ser Ala Phe Val Glu  Asn His Leu 
    1325                 1330                 1335             


Glu Trp  Phe Arg Phe Ser Gly  Arg Ile Leu Gly Leu  Ala Leu Ile 
    1340                 1345                 1350             


His Gln  Tyr Leu Leu Asp Ala  Phe Phe Thr Arg Pro  Phe Tyr Lys 
    1355                 1360                 1365             


Ala Leu  Leu Arg Leu Pro Cys  Asp Leu Ser Asp Leu  Glu Tyr Leu 
    1370                 1375                 1380             


Asp Glu  Glu Phe His Gln Ser  Leu Gln Trp Met Lys  Asp Asn Asn 
    1385                 1390                 1395             


Ile Thr  Asp Ile Leu Asp Leu  Thr Phe Thr Val Asn  Glu Glu Val 
    1400                 1405                 1410             


Phe Gly  Gln Val Thr Glu Arg  Glu Leu Lys Ser Gly  Gly Ala Asn 
    1415                 1420                 1425             


Thr Gln  Val Thr Glu Lys Asn  Lys Lys Glu Tyr Ile  Glu Arg Met 
    1430                 1435                 1440             


Val Lys  Trp Arg Val Glu Arg  Gly Val Val Gln Gln  Thr Glu Ala 
    1445                 1450                 1455             


Leu Val  Arg Gly Phe Tyr Glu  Val Val Asp Ser Arg  Leu Val Ser 
    1460                 1465                 1470             


Val Phe  Asp Ala Arg Glu Leu  Glu Leu Val Ile Ala  Gly Thr Ala 
    1475                 1480                 1485             


Glu Ile  Asp Leu Asn Asp Trp  Arg Asn Asn Thr Glu  Tyr Arg Gly 
    1490                 1495                 1500             


Gly Tyr  His Asp Gly His Leu  Val Ile Arg Trp Phe  Trp Ala Ala 
    1505                 1510                 1515             


Val Glu  Arg Phe Asn Asn Glu  Gln Arg Leu Arg Leu  Leu Gln Phe 
    1520                 1525                 1530             


Val Thr  Gly Thr Ser Ser Val  Pro Tyr Glu Gly Phe  Ala Ala Leu 
    1535                 1540                 1545             


Arg Gly  Ser Asn Gly Leu Arg  Arg Phe Cys Ile Glu  Lys Trp Gly 
    1550                 1555                 1560             


Lys Ile  Thr Ser Leu Pro Arg  Ala His Thr Cys Phe  Asn Arg Leu 
    1565                 1570                 1575             


Asp Leu  Pro Pro Tyr Pro Ser  Tyr Ser Met Leu Tyr  Glu Lys Leu 
    1580                 1585                 1590             


Leu Thr  Ala Val Glu Glu Thr  Ser Thr Phe Gly Leu  Glu 
    1595                 1600                 1605     


<210> 4974
<211> 790
<212> PRT
<213> Homo sapiens

<400> 4974
Met Gly Thr Arg Lys Lys Val His Ala Phe Val Arg Val Lys Pro Thr 
1               5                   10                  15      


Asp Asp Phe Ala His Glu Met Ile Arg Tyr Gly Asp Asp Lys Arg Ser 
            20                  25                  30          


Ile Asp Ile His Leu Lys Lys Asp Ile Arg Arg Gly Val Val Asn Asn 
        35                  40                  45              


Gln Gln Thr Asp Trp Ser Phe Lys Leu Asp Gly Val Leu His Asp Ala 
    50                  55                  60                  


Ser Gln Asp Leu Val Tyr Glu Thr Val Ala Lys Asp Val Val Ser Gln 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Gly Thr Ile Met Cys Tyr Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Lys Thr Tyr Thr Met Met Gly Ala Thr Glu Asn Tyr Lys His 
            100                 105                 110         


Arg Gly Ile Leu Pro Arg Ala Leu Gln Gln Val Phe Arg Met Ile Glu 
        115                 120                 125             


Glu Arg Pro Thr His Ala Ile Thr Val Arg Val Ser Tyr Leu Glu Ile 
    130                 135                 140                 


Tyr Asn Glu Ser Leu Phe Asp Leu Leu Ser Thr Leu Pro Tyr Val Gly 
145                 150                 155                 160 


Pro Ser Val Thr Pro Met Thr Ile Val Glu Asn Pro Gln Gly Val Phe 
                165                 170                 175     


Ile Lys Gly Leu Ser Val His Leu Thr Ser Gln Glu Glu Asp Ala Phe 
            180                 185                 190         


Ser Leu Leu Phe Glu Gly Glu Thr Asn Arg Ile Ile Ala Ser His Thr 
        195                 200                 205             


Met Asn Lys Asn Ser Ser Arg Ser His Cys Ile Phe Thr Ile Tyr Leu 
    210                 215                 220                 


Glu Ala His Ser Arg Thr Leu Ser Glu Glu Lys Tyr Ile Thr Ser Lys 
225                 230                 235                 240 


Ile Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Gly Lys Ser Gly 
                245                 250                 255     


Ser Glu Gly Gln Val Leu Lys Glu Ala Thr Tyr Ile Asn Lys Ser Leu 
            260                 265                 270         


Ser Phe Leu Glu Gln Ala Ile Ile Ala Leu Gly Asp Gln Lys Arg Asp 
        275                 280                 285             


His Ile Pro Phe Arg Gln Cys Lys Leu Thr His Ala Leu Lys Asp Ser 
    290                 295                 300                 


Leu Gly Gly Asn Cys Asn Met Val Leu Val Thr Asn Ile Tyr Gly Glu 
305                 310                 315                 320 


Ala Ala Gln Leu Glu Glu Thr Leu Ser Ser Leu Arg Phe Ala Ser Arg 
                325                 330                 335     


Met Lys Leu Val Thr Thr Glu Pro Ala Ile Asn Glu Lys Tyr Asp Ala 
            340                 345                 350         


Glu Arg Met Val Lys Asn Leu Glu Lys Glu Leu Ala Leu Leu Lys Gln 
        355                 360                 365             


Glu Leu Ala Ile His Asp Ser Leu Thr Asn Arg Thr Phe Val Thr Tyr 
    370                 375                 380                 


Asp Pro Met Asp Glu Ile Gln Ile Ala Glu Ile Asn Ser Gln Val Arg 
385                 390                 395                 400 


Arg Tyr Leu Glu Gly Thr Leu Asp Glu Ile Asp Ile Ile Ser Leu Arg 
                405                 410                 415     


Gln Ile Lys Glu Val Phe Asn Gln Phe Arg Val Val Leu Ser Gln Gln 
            420                 425                 430         


Glu Gln Glu Val Glu Ser Thr Leu Arg Arg Lys Tyr Thr Leu Ile Asp 
        435                 440                 445             


Arg Asn Asp Phe Ala Ala Ile Ser Ala Ile Gln Lys Ala Gly Leu Val 
    450                 455                 460                 


Asp Val Asp Gly His Leu Val Gly Glu Pro Glu Gly Gln Asn Phe Gly 
465                 470                 475                 480 


Leu Gly Val Ala Pro Phe Ser Thr Lys Pro Gly Lys Lys Ala Lys Ser 
                485                 490                 495     


Lys Lys Thr Phe Lys Glu Pro Leu Ser Ser Leu Ala Arg Lys Glu Gly 
            500                 505                 510         


Ala Ser Ser Pro Val Asn Gly Lys Asp Leu Asp Tyr Val Ser Thr Ser 
        515                 520                 525             


Lys Thr Gln Leu Val Pro Ser Ser Lys Asp Gly Asp Val Lys Asp Met 
    530                 535                 540                 


Leu Ser Arg Asp Arg Glu Thr Ser Ser Ile Glu Pro Leu Pro Ser Asp 
545                 550                 555                 560 


Ser Pro Lys Glu Glu Leu Arg Pro Ile Arg Pro Asp Thr Pro Pro Ser 
                565                 570                 575     


Lys Pro Val Ala Phe Glu Glu Phe Lys Asn Glu Gln Gly Ser Glu Ile 
            580                 585                 590         


Asn Arg Ile Phe Lys Glu Asn Lys Ser Ile Leu Asn Glu Arg Arg Lys 
        595                 600                 605             


Arg Ala Ser Glu Thr Thr Gln His Ile Asn Ala Ile Lys Arg Glu Ile 
    610                 615                 620                 


Asp Val Thr Lys Glu Ala Leu Asn Phe Gln Lys Ser Leu Arg Glu Lys 
625                 630                 635                 640 


Gln Gly Lys Tyr Glu Asn Lys Gly Leu Met Ile Ile Asp Glu Glu Glu 
                645                 650                 655     


Phe Leu Leu Ile Leu Lys Leu Lys Asp Leu Lys Lys Gln Tyr Arg Ser 
            660                 665                 670         


Glu Tyr Gln Asp Leu Arg Asp Leu Arg Ala Glu Ile Gln Tyr Cys Gln 
        675                 680                 685             


His Leu Val Asp Gln Cys Arg His Arg Leu Leu Met Glu Phe Asp Ile 
    690                 695                 700                 


Trp Tyr Asn Glu Ser Phe Val Ile Pro Glu Asp Met Gln Met Ala Leu 
705                 710                 715                 720 


Lys Pro Gly Gly Ser Ile Arg Pro Gly Met Val Pro Val Asn Arg Ile 
                725                 730                 735     


Val Ser Leu Gly Glu Asp Asp Gln Asp Lys Phe Ser Gln Leu Gln Gln 
            740                 745                 750         


Arg Val Leu Pro Glu Gly Pro Asp Ser Ile Ser Phe Tyr Asn Ala Lys 
        755                 760                 765             


Val Lys Ile Glu Gln Lys His Asn Tyr Leu Lys Thr Met Met Gly Leu 
    770                 775                 780                 


Gln Gln Ala His Arg Lys 
785                 790 


<210> 4975
<211> 291
<212> PRT
<213> Homo sapiens

<400> 4975
Met Ala Ser Val Thr Leu Ser Glu Ala Glu Lys Val Tyr Ile Val His 
1               5                   10                  15      


Gly Val Gln Glu Asp Leu Arg Val Asp Gly Arg Gly Cys Glu Asp Tyr 
            20                  25                  30          


Arg Cys Val Glu Val Glu Thr Asp Val Val Ser Asn Thr Ser Gly Ser 
        35                  40                  45              


Ala Arg Val Lys Leu Gly His Thr Asp Ile Leu Val Gly Val Lys Ala 
    50                  55                  60                  


Glu Met Gly Thr Pro Lys Leu Glu Lys Pro Asn Glu Gly Tyr Leu Glu 
65                  70                  75                  80  


Phe Phe Val Asp Cys Ser Ala Ser Ala Thr Pro Glu Phe Glu Gly Arg 
                85                  90                  95      


Gly Gly Asp Asp Leu Gly Thr Glu Ile Ala Asn Thr Leu Tyr Arg Ile 
            100                 105                 110         


Phe Asn Asn Lys Ser Ser Val Asp Leu Lys Thr Leu Cys Ile Ser Pro 
        115                 120                 125             


Arg Glu His Cys Trp Val Leu Tyr Val Asp Val Leu Leu Leu Glu Cys 
    130                 135                 140                 


Gly Gly Asn Leu Phe Asp Ala Ile Ser Ile Ala Val Lys Ala Ala Leu 
145                 150                 155                 160 


Phe Asn Thr Arg Ile Pro Arg Val Arg Val Leu Glu Asp Glu Glu Gly 
                165                 170                 175     


Ser Lys Asp Ile Glu Leu Ser Asp Asp Pro Tyr Asp Cys Ile Arg Leu 
            180                 185                 190         


Ser Val Glu Asn Val Pro Cys Ile Val Thr Leu Cys Lys Ile Gly Tyr 
        195                 200                 205             


Arg His Val Val Asp Ala Thr Leu Gln Glu Glu Ala Cys Ser Leu Ala 
    210                 215                 220                 


Ser Leu Leu Val Ser Val Thr Ser Lys Gly Val Val Thr Cys Met Arg 
225                 230                 235                 240 


Lys Val Gly Lys Gly Ser Leu Asp Pro Glu Ser Ile Phe Glu Met Met 
                245                 250                 255     


Glu Thr Gly Lys Arg Val Gly Lys Val Leu His Ala Ser Leu Gln Ser 
            260                 265                 270         


Val Val His Lys Glu Glu Ser Leu Gly Pro Lys Arg Gln Lys Val Gly 
        275                 280                 285             


Phe Leu Gly 
    290     


<210> 4976
<211> 793
<212> PRT
<213> Homo sapiens

<400> 4976
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn Glu Glu Lys Ile Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Ile Val His Pro Ser Gln Glu Glu Asp Arg His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val Arg Leu Ser Arg Asp 
    210                 215                 220                 


Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro Asp Pro Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Ile Ile Glu Gln Leu Leu Ser Asn Ile Phe 
                245                 250                 255     


His Lys Glu Lys Asn Glu Ser Ala Ile Val Ser Ala Ile Gln Ile Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His Ile Glu 
        275                 280                 285             


Ile Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn Lys Ser 
    290                 295                 300                 


Val Leu Glu Ala Ile Arg Gly Arg Leu Gly Ser Phe His Glu Leu Leu 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Asn Met Phe Phe Lys Tyr Thr Trp Asn Asn Phe 
                325                 330                 335     


Leu His Thr Gln Val Glu Ile Cys Ile Ala Leu Ile Leu Ala Ser Pro 
            340                 345                 350         


Phe Glu Asn Thr Glu Asn Ala Thr Ile Thr Asp Gln Asp Ser Thr Gly 
        355                 360                 365             


Asp Asn Leu Leu Leu Lys His Leu Phe Gln Lys Cys Gln Leu Ile Glu 
    370                 375                 380                 


Arg Ile Leu Glu Ala Trp Glu Met Asn Glu Lys Lys Gln Ala Glu Gly 
385                 390                 395                 400 


Gly Arg Arg His Gly Tyr Met Gly His Leu Thr Arg Ile Ala Asn Cys 
                405                 410                 415     


Ile Val His Ser Thr Asp Lys Gly Pro Asn Ser Ala Leu Val Gln Gln 
            420                 425                 430         


Leu Ile Lys Asp Leu Pro Asp Glu Val Arg Glu Arg Trp Glu Thr Phe 
        435                 440                 445             


Cys Thr Ser Ser Leu Gly Glu Thr Asn Lys Arg Asn Thr Val Asp Leu 
    450                 455                 460                 


Ala Phe Ser Asp Tyr Gln Met Gln Gln Met Thr Ser Asn Phe Ile Asp 
465                 470                 475                 480 


Gln Phe Gly Phe Asn Asp Glu Lys Phe Ala Asp Gln Asp Asp Ile Gly 
                485                 490                 495     


Asn Val Ser Phe Asp Arg Val Ser Asp Ile Asn Phe Thr Leu Asn Thr 
            500                 505                 510         


Asn Glu Ser Gly Asn Ile Ala Leu Phe Glu Ala Cys Cys Lys Glu Arg 
        515                 520                 525             


Ile Gln Gln Phe Asp Asp Gly Gly Ser Asp Glu Glu Asp Ile Trp Glu 
    530                 535                 540                 


Glu Lys His Ile Ala Phe Thr Pro Glu Ser Gln Arg Arg Ser Ser Ser 
545                 550                 555                 560 


Gly Ser Thr Asp Ser Glu Glu Ser Thr Asp Ser Glu Glu Glu Asp Gly 
                565                 570                 575     


Ala Lys Gln Asp Leu Phe Glu Pro Ser Ser Ala Asn Thr Glu Asp Lys 
            580                 585                 590         


Met Glu Val Asp Leu Ser Glu Pro Pro Asn Trp Ser Ala Asn Phe Asp 
        595                 600                 605             


Val Pro Met Glu Thr Thr His Gly Ala Pro Leu Asp Ser Val Gly Ser 
    610                 615                 620                 


Asp Val Trp Ser Thr Glu Glu Pro Met Pro Thr Lys Glu Thr Gly Trp 
625                 630                 635                 640 


Ala Ser Phe Ser Glu Phe Thr Ser Ser Leu Ser Thr Lys Asp Ser Leu 
                645                 650                 655     


Arg Ser Asn Ser Pro Val Glu Met Glu Thr Ser Thr Glu Pro Met Asp 
            660                 665                 670         


Pro Leu Thr Pro Ser Ala Ala Ala Leu Ala Val Gln Pro Glu Ala Ala 
        675                 680                 685             


Gly Ser Val Ala Met Glu Ala Ser Ser Asp Gly Glu Glu Asp Ala Glu 
    690                 695                 700                 


Ser Thr Asp Lys Val Thr Glu Thr Val Met Asn Gly Gly Met Lys Glu 
705                 710                 715                 720 


Thr Leu Ser Leu Thr Val Asp Ala Lys Thr Glu Thr Ala Val Phe Lys 
                725                 730                 735     


Ser Glu Glu Gly Lys Leu Ser Thr Ser Gln Asp Ala Ala Cys Lys Asp 
            740                 745                 750         


Ala Glu Glu Cys Pro Glu Thr Ala Glu Ala Lys Cys Ala Ala Pro Arg 
        755                 760                 765             


Pro Pro Ser Ser Ser Pro Glu Gln Arg Thr Gly Gln Pro Ser Ala Pro 
    770                 775                 780                 


Gly Asp Thr Ser Val Asn Gly Pro Val 
785                 790             


<210> 4977
<211> 1124
<212> PRT
<213> Homo sapiens

<400> 4977
Met Asp Pro Phe Thr Glu Lys Leu Leu Glu Arg Thr Arg Ala Arg Arg 
1               5                   10                  15      


Glu Asn Leu Gln Arg Lys Met Ala Glu Arg Pro Thr Ala Ala Pro Arg 
            20                  25                  30          


Ser Met Thr His Ala Lys Arg Ala Arg Gln Pro Leu Ser Glu Ala Ser 
        35                  40                  45              


Asn Gln Gln Pro Leu Ser Gly Gly Glu Glu Lys Ser Cys Thr Lys Pro 
    50                  55                  60                  


Ser Pro Ser Lys Lys Arg Cys Ser Asp Asn Thr Glu Val Glu Val Ser 
65                  70                  75                  80  


Asn Leu Glu Asn Lys Gln Pro Val Glu Ser Thr Ser Ala Lys Ser Cys 
                85                  90                  95      


Ser Pro Ser Pro Val Ser Pro Gln Val Gln Pro Gln Ala Ala Asp Thr 
            100                 105                 110         


Ile Ser Asp Ser Val Ala Val Pro Ala Ser Leu Leu Gly Met Arg Arg 
        115                 120                 125             


Gly Leu Asn Ser Arg Leu Glu Ala Thr Ala Ala Ser Ser Val Lys Thr 
    130                 135                 140                 


Arg Met Gln Lys Leu Ala Glu Gln Arg Arg Arg Trp Asp Asn Asp Asp 
145                 150                 155                 160 


Met Thr Asp Asp Ile Pro Glu Ser Ser Leu Phe Ser Pro Met Pro Ser 
                165                 170                 175     


Glu Glu Lys Ala Ala Ser Pro Pro Arg Pro Leu Leu Ser Asn Ala Ser 
            180                 185                 190         


Ala Thr Pro Val Gly Arg Arg Gly Arg Leu Ala Asn Leu Ala Ala Thr 
        195                 200                 205             


Ile Cys Ser Trp Glu Asp Asp Val Asn His Ser Phe Ala Lys Gln Asn 
    210                 215                 220                 


Ser Val Gln Glu Gln Pro Gly Thr Ala Cys Leu Ser Lys Phe Ser Ser 
225                 230                 235                 240 


Ala Ser Gly Ala Ser Ala Arg Ile Asn Ser Ser Ser Val Lys Gln Glu 
                245                 250                 255     


Ala Thr Phe Cys Ser Gln Arg Asp Gly Asp Ala Ser Leu Asn Lys Ala 
            260                 265                 270         


Leu Ser Ser Ser Ala Asp Asp Ala Ser Leu Val Asn Ala Ser Ile Ser 
        275                 280                 285             


Ser Ser Val Lys Ala Thr Ser Pro Val Lys Ser Thr Thr Ser Ile Thr 
    290                 295                 300                 


Asp Ala Lys Ser Cys Glu Gly Gln Asn Pro Glu Leu Leu Pro Lys Thr 
305                 310                 315                 320 


Pro Ile Ser Pro Leu Lys Thr Gly Val Ser Lys Pro Ile Val Lys Ser 
                325                 330                 335     


Thr Leu Ser Gln Thr Val Pro Ser Lys Gly Glu Leu Ser Arg Glu Ile 
            340                 345                 350         


Cys Leu Gln Ser Gln Ser Lys Asp Lys Ser Thr Thr Pro Gly Gly Thr 
        355                 360                 365             


Gly Ile Lys Pro Phe Leu Glu Arg Phe Gly Glu Arg Cys Gln Glu His 
    370                 375                 380                 


Ser Lys Glu Ser Pro Ala Arg Ser Thr Pro His Arg Thr Pro Ile Ile 
385                 390                 395                 400 


Thr Pro Asn Thr Lys Ala Ile Gln Glu Arg Leu Phe Lys Gln Asp Thr 
                405                 410                 415     


Ser Ser Ser Thr Thr His Leu Ala Gln Gln Leu Lys Gln Glu Arg Gln 
            420                 425                 430         


Lys Glu Leu Ala Cys Leu Arg Gly Arg Phe Asp Lys Gly Asn Ile Trp 
        435                 440                 445             


Ser Ala Glu Lys Gly Gly Asn Ser Lys Ser Lys Gln Leu Glu Thr Lys 
    450                 455                 460                 


Gln Glu Thr His Cys Gln Ser Thr Pro Leu Lys Lys His Gln Gly Val 
465                 470                 475                 480 


Ser Lys Thr Gln Ser Leu Pro Val Thr Glu Lys Val Thr Glu Asn Gln 
                485                 490                 495     


Ile Pro Ala Lys Asn Ser Ser Thr Glu Pro Lys Gly Phe Thr Glu Cys 
            500                 505                 510         


Glu Met Thr Lys Ser Ser Pro Leu Lys Ile Thr Leu Phe Leu Glu Glu 
        515                 520                 525             


Asp Lys Ser Leu Lys Val Thr Ser Asp Pro Lys Val Glu Gln Lys Ile 
    530                 535                 540                 


Glu Val Ile Arg Glu Ile Glu Met Ser Val Asp Asp Asp Asp Ile Asn 
545                 550                 555                 560 


Ser Ser Lys Val Ile Asn Asp Leu Phe Ser Asp Val Leu Glu Glu Gly 
                565                 570                 575     


Glu Leu Asp Met Glu Lys Ser Gln Glu Glu Met Asp Gln Ala Leu Ala 
            580                 585                 590         


Glu Ser Ser Glu Glu Gln Glu Asp Ala Leu Asn Ile Ser Ser Met Ser 
        595                 600                 605             


Leu Leu Ala Pro Leu Ala Gln Thr Val Gly Val Val Ser Pro Glu Ser 
    610                 615                 620                 


Leu Val Ser Thr Pro Arg Leu Glu Leu Lys Asp Thr Ser Arg Ser Asp 
625                 630                 635                 640 


Glu Ser Pro Lys Pro Gly Lys Phe Gln Arg Thr Arg Val Pro Arg Ala 
                645                 650                 655     


Glu Ser Gly Asp Ser Leu Gly Ser Glu Asp Arg Asp Leu Leu Tyr Ser 
            660                 665                 670         


Ile Asp Ala Tyr Arg Ser Gln Arg Phe Lys Glu Thr Glu Arg Pro Ser 
        675                 680                 685             


Ile Lys Gln Val Ile Val Arg Lys Glu Asp Val Thr Ser Lys Leu Asp 
    690                 695                 700                 


Glu Lys Asn Asn Ala Phe Pro Cys Gln Val Asn Ile Lys Gln Lys Met 
705                 710                 715                 720 


Gln Glu Leu Asn Asn Glu Ile Asn Met Gln Gln Thr Val Ile Tyr Gln 
                725                 730                 735     


Ala Ser Gln Ala Leu Asn Cys Cys Val Asp Glu Glu His Gly Lys Gly 
            740                 745                 750         


Ser Leu Glu Glu Ala Glu Ala Glu Arg Leu Leu Leu Ile Ala Thr Gly 
        755                 760                 765             


Lys Arg Thr Leu Leu Ile Asp Glu Leu Asn Lys Leu Lys Asn Glu Gly 
    770                 775                 780                 


Pro Gln Arg Lys Asn Lys Ala Ser Pro Gln Ser Glu Phe Met Pro Ser 
785                 790                 795                 800 


Lys Gly Ser Val Thr Leu Ser Glu Ile Arg Leu Pro Leu Lys Ala Asp 
                805                 810                 815     


Phe Val Cys Ser Thr Val Gln Lys Pro Asp Ala Ala Asn Tyr Tyr Tyr 
            820                 825                 830         


Leu Ile Ile Leu Lys Ala Gly Ala Glu Asn Met Val Ala Thr Pro Leu 
        835                 840                 845             


Ala Ser Thr Ser Asn Ser Leu Asn Gly Asp Ala Leu Thr Phe Thr Thr 
    850                 855                 860                 


Thr Phe Thr Leu Gln Asp Val Ser Asn Asp Phe Glu Ile Asn Ile Glu 
865                 870                 875                 880 


Val Tyr Ser Leu Val Gln Lys Lys Asp Pro Ser Gly Leu Asp Lys Lys 
                885                 890                 895     


Lys Lys Thr Ser Lys Ser Lys Ala Ile Thr Pro Lys Arg Leu Leu Thr 
            900                 905                 910         


Ser Ile Thr Thr Lys Ser Asn Ile His Ser Ser Val Met Ala Ser Pro 
        915                 920                 925             


Gly Gly Leu Ser Ala Val Arg Thr Ser Asn Phe Ala Leu Val Gly Ser 
    930                 935                 940                 


Tyr Thr Leu Ser Leu Ser Ser Val Gly Asn Thr Lys Phe Val Leu Asp 
945                 950                 955                 960 


Lys Val Pro Phe Leu Ser Ser Leu Glu Gly His Ile Tyr Leu Lys Ile 
                965                 970                 975     


Lys Cys Gln Val Asn Ser Ser Val Glu Glu Arg Gly Phe Leu Thr Ile 
            980                 985                 990         


Phe Glu Asp Val Ser Gly Phe Gly  Ala Trp His Arg Arg  Trp Cys Val 
        995                 1000                 1005             


Leu Ser  Gly Asn Cys Ile Ser  Tyr Trp Thr Tyr Pro  Asp Asp Glu 
    1010                 1015                 1020             


Lys Arg  Lys Asn Pro Ile Gly  Arg Ile Asn Leu Ala  Asn Cys Thr 
    1025                 1030                 1035             


Ser Arg  Gln Ile Glu Pro Ala  Asn Arg Glu Phe Cys  Ala Arg Arg 
    1040                 1045                 1050             


Asn Thr  Phe Glu Leu Ile Thr  Val Arg Pro Gln Arg  Glu Asp Asp 
    1055                 1060                 1065             


Arg Glu  Thr Leu Val Ser Gln  Cys Arg Asp Thr Leu  Cys Val Thr 
    1070                 1075                 1080             


Lys Asn  Trp Leu Ser Ala Asp  Thr Lys Glu Glu Arg  Asp Leu Trp 
    1085                 1090                 1095             


Met Gln  Lys Leu Asn Gln Val  Leu Val Asp Ile Arg  Leu Trp Gln 
    1100                 1105                 1110             


Pro Asp  Ala Cys Tyr Lys Pro  Ile Gly Lys Pro 
    1115                 1120                 


<210> 4978
<211> 454
<212> PRT
<213> Homo sapiens

<400> 4978
Met Leu Lys Gln Ile Leu Ser Glu Met Tyr Ile Asp Pro Asp Leu Leu 
1               5                   10                  15      


Ala Glu Leu Ser Glu Glu Gln Lys Gln Ile Leu Phe Phe Lys Met Arg 
            20                  25                  30          


Glu Glu Gln Ile Arg Arg Trp Lys Glu Arg Glu Ala Ala Met Glu Arg 
        35                  40                  45              


Lys Glu Ser Leu Pro Val Lys Pro Arg Pro Lys Lys Glu Asn Gly Lys 
    50                  55                  60                  


Ser Val His Trp Lys Leu Gly Ala Asp Lys Glu Val Trp Val Trp Val 
65                  70                  75                  80  


Met Gly Glu His His Leu Asp Lys Pro Tyr Asp Val Leu Cys Asn Glu 
                85                  90                  95      


Ile Ile Ala Glu Arg Ala Arg Leu Lys Ala Glu Gln Glu Ala Glu Glu 
            100                 105                 110         


Pro Arg Lys Thr His Ser Glu Glu Phe Thr Asn Ser Leu Lys Thr Lys 
        115                 120                 125             


Ser Gln Tyr His Asp Leu Gln Ala Pro Asp Asn Gln Gln Thr Lys Asp 
    130                 135                 140                 


Ile Trp Lys Lys Val Ala Glu Lys Glu Glu Leu Glu Gln Gly Ser Arg 
145                 150                 155                 160 


Pro Ala Pro Thr Leu Glu Glu Glu Lys Ile Arg Ser Leu Ser Ser Ser 
                165                 170                 175     


Ser Arg Asn Ile Gln Gln Met Leu Ala Asp Ser Ile Asn Arg Met Lys 
            180                 185                 190         


Ala Tyr Ala Phe His Gln Lys Lys Glu Ser Met Lys Lys Lys Gln Asp 
        195                 200                 205             


Glu Glu Ile Asn Gln Ile Glu Glu Glu Arg Thr Lys Gln Ile Cys Lys 
    210                 215                 220                 


Ser Trp Lys Glu Asp Ser Glu Trp Gln Ala Ser Leu Arg Lys Ser Lys 
225                 230                 235                 240 


Ala Ala Asp Glu Lys Arg Arg Ser Leu Ala Lys Gln Ala Arg Glu Asp 
                245                 250                 255     


Tyr Lys Arg Leu Ser Leu Gly Ala Gln Lys Gly Arg Gly Gly Glu Arg 
            260                 265                 270         


Leu Gln Ser Pro Leu Arg Val Pro Gln Lys Pro Glu Arg Pro Pro Leu 
        275                 280                 285             


Pro Pro Lys Pro Gln Phe Leu Asn Ser Gly Ala Tyr Pro Gln Lys Pro 
    290                 295                 300                 


Leu Arg Asn Gln Gly Val Val Arg Thr Leu Ser Ser Ser Ala Gln Glu 
305                 310                 315                 320 


Asp Ile Ile Arg Trp Phe Lys Glu Glu Gln Leu Pro Leu Arg Ala Gly 
                325                 330                 335     


Tyr Gln Lys Thr Ser Asp Thr Ile Ala Pro Trp Phe His Gly Ile Leu 
            340                 345                 350         


Thr Leu Lys Lys Ala Asn Glu Leu Leu Leu Ser Thr Gly Met Pro Gly 
        355                 360                 365             


Ser Phe Leu Ile Arg Val Ser Glu Arg Ile Lys Gly Tyr Ala Leu Ser 
    370                 375                 380                 


Tyr Leu Ser Glu Asp Gly Cys Lys His Phe Leu Ile Asp Ala Ser Ala 
385                 390                 395                 400 


Asp Ala Tyr Ser Phe Leu Gly Val Asp Gln Leu Gln His Ala Thr Leu 
                405                 410                 415     


Ala Asp Leu Val Glu Tyr His Lys Glu Glu Pro Ile Thr Ser Leu Gly 
            420                 425                 430         


Lys Glu Leu Leu Leu Tyr Pro Cys Gly Gln Gln Asp Gln Leu Pro Asp 
        435                 440                 445             


Tyr Leu Glu Leu Phe Glu 
    450                 


<210> 4979
<211> 498
<212> PRT
<213> Homo sapiens

<400> 4979
Met Asp Glu Thr Glu Trp Ile His Arg His Pro Lys Ala Glu Asp Leu 
1               5                   10                  15      


Arg Val Gly Leu Ile Ser Trp Ala Gly Thr Tyr Leu Thr Phe Glu Ala 
            20                  25                  30          


Cys Lys Asn Thr Val Thr Ala Thr Ala Lys Ser Leu Gly Arg Arg Gln 
        35                  40                  45              


Thr Trp Glu Ile Leu Val Ser Asn Glu His Glu Thr Gln Ala Val Val 
    50                  55                  60                  


Arg Leu Lys Ser Val Gln Gly Leu Tyr Leu Leu Cys Glu Cys Asp Gly 
65                  70                  75                  80  


Thr Val Cys Tyr Gly Arg Pro Arg Thr Ser His His Gly Cys Phe Leu 
                85                  90                  95      


Leu Arg Phe His Arg Asn Ser Lys Trp Thr Leu Gln Cys Leu Ile Ser 
            100                 105                 110         


Gly Arg Tyr Leu Glu Ser Asn Gly Lys Asp Val Phe Cys Thr Ser His 
        115                 120                 125             


Val Leu Ser Ala Tyr His Met Trp Thr Pro Arg Pro Ala Leu His Val 
    130                 135                 140                 


His Val Ile Leu Tyr Ser Pro Ile His Arg Cys Tyr Ala Arg Ala Asp 
145                 150                 155                 160 


Pro Thr Met Gly Arg Ile Trp Val Asp Ala Ala Val Pro Cys Leu Glu 
                165                 170                 175     


Glu Cys Gly Phe Leu Leu His Phe Arg Asp Gly Cys Tyr His Leu Glu 
            180                 185                 190         


Thr Ser Thr His His Phe Leu Ser His Val Asp Arg Leu Phe Ser Gln 
        195                 200                 205             


Pro Ser Ser Gln Thr Ala Phe His Met Gln Val Arg Pro Gly Gly Leu 
    210                 215                 220                 


Val Ala Leu Cys Asp Gly Glu Gly Gly Met Leu Tyr Pro Gln Gly Thr 
225                 230                 235                 240 


His Leu Leu Leu Gly Met Gly Cys Asn Pro Met Arg Gly Glu Glu Trp 
                245                 250                 255     


Phe Ile Leu Gln His Cys Pro Thr Trp Val Ser Leu Arg Ser Lys Thr 
            260                 265                 270         


Gly Arg Phe Ile Ser Val Ile Tyr Asp Gly Glu Val Arg Ala Ala Ser 
        275                 280                 285             


Glu Arg Leu Asn Arg Met Ser Leu Phe Gln Phe Glu Cys Asp Ser Glu 
    290                 295                 300                 


Ser Pro Thr Val Gln Leu Arg Ser Ala Asn Gly Tyr Tyr Leu Ser Gln 
305                 310                 315                 320 


Arg Arg His Arg Ala Val Met Ala Asp Gly His Pro Leu Glu Ser Asp 
                325                 330                 335     


Thr Phe Phe Arg Met His Trp Asn Cys Gly Arg Ile Ile Leu Gln Ser 
            340                 345                 350         


Cys Arg Gly Arg Phe Leu Gly Ile Ala Pro Asn Ser Leu Leu Met Ala 
        355                 360                 365             


Asn Val Ile Leu Pro Gly Pro Asn Glu Glu Phe Gly Ile Leu Phe Ala 
    370                 375                 380                 


Asn Arg Ser Phe Leu Val Leu Arg Gly Arg Tyr Gly Tyr Val Gly Ser 
385                 390                 395                 400 


Ser Ser Gly His Asp Leu Ile Gln Cys Asn Gln Asp Gln Pro Asp Arg 
                405                 410                 415     


Ile His Leu Leu Pro Cys Arg Pro Gly Ile Tyr His Phe Gln Ala Gln 
            420                 425                 430         


Gly Gly Ser Phe Trp Ser Ile Thr Ser Phe Gly Thr Phe Arg Pro Trp 
        435                 440                 445             


Gly Lys Phe Ala Leu Asn Phe Cys Ile Glu Leu Gln Gly Ser Asn Leu 
    450                 455                 460                 


Leu Thr Val Leu Ala Pro Asn Gly Phe Tyr Met Arg Ala Asp Gln Ser 
465                 470                 475                 480 


Gly Thr Leu Leu Ala Asp Ser Glu Asp Ile Thr Arg Glu Cys Ile Trp 
                485                 490                 495     


Glu Phe 
        


<210> 4980
<211> 458
<212> PRT
<213> Homo sapiens

<400> 4980
Met Glu Arg Glu Pro Ser Ala Ser Glu Ala Ala Pro Ala Ala Ala Ala 
1               5                   10                  15      


Leu Phe Ala Trp Gly Ala Asn Ser Tyr Gly Gln Leu Gly Leu Gly His 
            20                  25                  30          


Lys Glu Asp Val Leu Leu Pro Gln Gln Leu Asn Asp Phe Cys Lys Pro 
        35                  40                  45              


Arg Ser Val Arg Arg Ile Thr Gly Gly Gly Gly His Ser Ala Val Val 
    50                  55                  60                  


Thr Asp Gly Gly Asp Leu Phe Val Cys Gly Leu Asn Lys Asp Gly Gln 
65                  70                  75                  80  


Leu Gly Leu Gly His Thr Glu Asp Ile Pro Tyr Phe Thr Pro Cys Lys 
                85                  90                  95      


Ser Leu Phe Gly Cys Pro Ile Gln Gln Val Ala Cys Gly Trp Asp Phe 
            100                 105                 110         


Thr Ile Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys Gly Ser Asn 
        115                 120                 125             


Ser Phe Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg Cys Val Val 
    130                 135                 140                 


Pro Gln Ala Ile Glu Leu His Lys Glu Lys Val Val Cys Ile Ala Ala 
145                 150                 155                 160 


Gly Leu Arg His Ala Val Ala Ala Thr Ala Ser Gly Ile Val Phe Gln 
                165                 170                 175     


Trp Gly Thr Gly Leu Ala Ser Cys Gly Arg Arg Leu Cys Pro Gly Gln 
            180                 185                 190         


Thr Leu Pro Leu Phe Phe Thr Ala Lys Glu Pro Ser Arg Val Thr Gly 
        195                 200                 205             


Leu Glu Asn Ser Lys Ala Met Cys Val Leu Ala Gly Ser Asp His Ser 
    210                 215                 220                 


Ala Ser Leu Thr Asp Ala Gly Glu Val Tyr Val Trp Gly Ser Asn Lys 
225                 230                 235                 240 


His Gly Gln Leu Ala Asn Glu Ala Ala Phe Leu Pro Val Pro Gln Lys 
                245                 250                 255     


Ile Glu Ala His Cys Phe Gln Asn Glu Lys Val Thr Ala Ile Trp Ser 
            260                 265                 270         


Gly Trp Thr His Leu Val Ala Gln Thr Glu Thr Gly Lys Met Phe Thr 
        275                 280                 285             


Trp Gly Arg Ala Asp Tyr Gly Gln Leu Gly Arg Lys Leu Glu Thr Tyr 
    290                 295                 300                 


Glu Gly Trp Lys Leu Glu Lys Gln Asp Ser Phe Leu Pro Cys Ser Arg 
305                 310                 315                 320 


Pro Pro Asn Ser Met Pro Ser Ser Pro His Cys Leu Thr Gly Ala Thr 
                325                 330                 335     


Glu Val Ser Cys Gly Ser Glu His Asn Leu Ala Ile Ile Gly Gly Val 
            340                 345                 350         


Cys Tyr Ser Trp Gly Trp Asn Glu His Gly Met Cys Gly Asp Gly Thr 
        355                 360                 365             


Glu Ala Asn Val Trp Ala Pro Lys Pro Val Gln Ala Leu Leu Ser Ser 
    370                 375                 380                 


Ser Gly Leu Leu Val Gly Cys Gly Ala Gly His Ser Leu Ala Leu Cys 
385                 390                 395                 400 


Gln Leu Pro Ala His Pro Ala Leu Val Gln Asp Pro Lys Val Thr Tyr 
                405                 410                 415     


Leu Ser Pro Asp Ala Ile Glu Asp Thr Glu Ser Gln Lys Ala Met Asp 
            420                 425                 430         


Lys Glu Arg Asn Trp Lys Glu Arg Gln Ser Glu Thr Ser Thr Gln Ser 
        435                 440                 445             


Gln Ser Asp Trp Ser Arg Asn Gly Gly Leu 
    450                 455             


<210> 4981
<211> 986
<212> PRT
<213> Homo sapiens

<400> 4981
Met Glu Arg Met Asn Trp Leu Ser Arg Leu Ala Ser Arg Gly Pro Gly 
1               5                   10                  15      


His Arg Ile Pro Gln Gly Ala Asn Leu Gln Thr Pro Val Met Ala Asp 
            20                  25                  30          


Pro Glu Thr Cys Leu Met Val Phe Lys Asn His Trp Ser Gln Val Val 
        35                  40                  45              


Arg Ile Leu Glu Arg Gln Gly Pro Arg Ala Ala Pro Gly Gly Ala Asp 
    50                  55                  60                  


Asp Leu Ser Ala Val Arg Asn His Thr Tyr Gln Met Leu Thr Leu Leu 
65                  70                  75                  80  


Ala Glu Asp Arg Ala Val Pro Ser Ala Pro Thr Gly Pro Gly Pro Leu 
                85                  90                  95      


Leu Glu Phe Ala Leu His Glu Asp Leu Leu Thr Arg Val Leu Thr Trp 
            100                 105                 110         


Gln Leu Gln Trp Asp Glu Leu Gly Asp Gly Val Glu Glu Arg Arg Ala 
        115                 120                 125             


Glu Gln Leu Lys Leu Phe Glu Met Leu Val Ser Glu Ala Arg Gln Pro 
    130                 135                 140                 


Leu Leu Arg His Gly Pro Val Arg Glu Ala Leu Leu Thr Leu Leu Asp 
145                 150                 155                 160 


Ala Cys Gly Arg Pro Val Pro Ser Ser Pro Ala Leu Asp Glu Gly Leu 
                165                 170                 175     


Val Leu Leu Leu Ser Gln Leu Cys Val Cys Val Ala Gln Glu Pro Ser 
            180                 185                 190         


Leu Leu Glu Phe Phe Leu Gln Pro Pro Pro Glu Pro Gly Ala Ala Pro 
        195                 200                 205             


Arg Leu Leu Leu Phe Ser Arg Leu Val Pro Phe Val His Arg Glu Gly 
    210                 215                 220                 


Thr Leu Gly Gln Gln Ala Arg Asp Ala Leu Leu Leu Leu Met Ala Leu 
225                 230                 235                 240 


Ser Ala Gly Ser Pro Thr Val Gly Arg Tyr Ile Ala Asp His Ser Tyr 
                245                 250                 255     


Phe Cys Pro Val Leu Ala Thr Gly Leu Ser Ala Leu Tyr Ser Ser Leu 
            260                 265                 270         


Pro Arg Lys Ile Glu Val Pro Gly Asp Asp Trp His Cys Leu Arg Arg 
        275                 280                 285             


Glu Asp Trp Leu Gly Val Pro Ala Leu Ala Leu Phe Met Ser Ser Leu 
    290                 295                 300                 


Glu Phe Cys Asn Ala Val Ile Gln Val Ala His Pro Leu Val Gln Lys 
305                 310                 315                 320 


Gln Leu Val Asp Tyr Ile His Asn Gly Phe Leu Val Pro Val Met Gly 
                325                 330                 335     


Pro Ala Leu His Lys Thr Ser Val Glu Glu Met Ile Ala Ser Thr Ala 
            340                 345                 350         


Tyr Leu Glu Leu Phe Leu Arg Ser Ile Ser Glu Pro Ala Leu Leu Arg 
        355                 360                 365             


Thr Phe Leu Arg Phe Leu Leu Leu His Arg His Asp Thr His Thr Ile 
    370                 375                 380                 


Leu Asp Thr Leu Val Ala Arg Ile Gly Ser Asn Ser Arg Leu Cys Met 
385                 390                 395                 400 


Val Ser Leu Ser Leu Phe Arg Thr Leu Leu Asn Leu Ser Cys Glu Asp 
                405                 410                 415     


Val Leu Leu Gln Leu Val Leu Arg Tyr Leu Val Pro Cys Asn His Val 
            420                 425                 430         


Met Leu Ser Gln Lys Pro Ala Val Arg Asp Val Asp Leu Tyr Gly Arg 
        435                 440                 445             


Ala Ala Asp Lys Phe Leu Ser Leu Ile Pro Arg Cys Cys Arg His His 
    450                 455                 460                 


Ala Pro Ser Pro Pro Arg Pro Glu His Ala Ser Trp Ala Arg Gly Gly 
465                 470                 475                 480 


Pro Ser Arg Glu Thr Gly Arg Arg Glu Asp Ile Thr Gly Pro Gly Ser 
                485                 490                 495     


Pro Ser Val Asp Ser Ser Ser Val Thr Thr Val Pro Arg Pro Ser Thr 
            500                 505                 510         


Pro Ser Arg Leu Ala Leu Phe Leu Arg Gln Gln Ser Leu Gly Gly Ser 
        515                 520                 525             


Glu Ser Pro Gly Pro Ala Pro Cys Ser Pro Gly Leu Ser Ala Ser Pro 
    530                 535                 540                 


Ala Ser Ser Pro Gly Arg Arg Pro Thr Pro Ala Glu Glu Pro Gly Glu 
545                 550                 555                 560 


Leu Glu Asp Asn Tyr Leu Glu Tyr Leu Arg Glu Ala Arg Arg Gly Val 
                565                 570                 575     


Asp Arg Cys Val Arg Ala Cys Arg Thr Trp Ser Ala Pro Tyr Asp Gly 
            580                 585                 590         


Glu Arg Pro Ser Pro Glu Pro Ser Pro Phe Gly Ser Arg Thr Lys Lys 
        595                 600                 605             


Arg Ser Leu Leu Pro Glu Glu Asp Arg Asn Asn Val Gly Glu Gly Glu 
    610                 615                 620                 


Glu Glu Glu Leu Gly Arg Arg Gly Arg Ala Gly Gly Ala Gly Glu Gly 
625                 630                 635                 640 


Pro Gly His Leu Pro Pro Pro Gln Leu Asn Gly Val Pro Gly Ser Trp 
                645                 650                 655     


Pro Glu Gly Ala Lys Lys Val Arg Leu Val Pro Lys Glu Gly Ala Gly 
            660                 665                 670         


Glu Leu Leu Glu Gly Ile Ser Glu Gly Met Ala Gly Leu Glu Gly Phe 
        675                 680                 685             


Gly Gln Glu Leu Arg Glu Leu Glu Val Ala Leu Ser Asn Gly Gly Thr 
    690                 695                 700                 


Gly Ser Glu Ser Pro Leu Glu Pro Pro Leu Pro Leu Glu Glu Glu Glu 
705                 710                 715                 720 


Ala Tyr Glu Ser Phe Thr Cys Pro Pro Glu Pro Pro Gly Pro Phe Leu 
                725                 730                 735     


Ser Ser Pro Leu Arg Thr Leu Asn Gln Leu Pro Ser Gln Pro Phe Thr 
            740                 745                 750         


Gly Pro Phe Met Ala Val Leu Phe Ala Lys Leu Glu Asn Met Leu Gln 
        755                 760                 765             


Asn Ser Val Tyr Val Asn Phe Leu Leu Thr Gly Leu Val Ala Gln Leu 
    770                 775                 780                 


Ala Cys His Pro Gln Pro Leu Leu Arg Ser Phe Leu Leu Asn Thr Asn 
785                 790                 795                 800 


Met Val Phe Gln Pro Ser Val Lys Ser Leu Leu Gln Val Leu Gly Ser 
                805                 810                 815     


Val Lys Asn Lys Ile Glu Asn Phe Ala Ala Ser Gln Glu Asp Phe Pro 
            820                 825                 830         


Ala Leu Leu Ser Lys Ala Lys Lys Tyr Leu Ile Ala Arg Gly Lys Leu 
        835                 840                 845             


Asp Trp Ala Glu Gly Pro Ala Ala Gly Pro Ala Pro Arg Arg Ser Asp 
    850                 855                 860                 


Pro Leu Val Lys Ser Arg Arg Pro Ser Leu Gly Glu Leu Leu Leu Arg 
865                 870                 875                 880 


His Ala His Ser Pro Thr Arg Ala Arg Gln Ala Ala Gln Leu Val Leu 
                885                 890                 895     


Gln Pro Gly Arg Asp Gly Ala Gly Leu Gly Leu Ser Gly Gly Ser Pro 
            900                 905                 910         


Gly Ala Ser Thr Pro Val Leu Leu Thr Arg Gly Gly Ala Pro Glu Arg 
        915                 920                 925             


Gln Gly Glu Ala Leu Arg Val Lys Asn Ala Val Tyr Cys Ala Val Ile 
    930                 935                 940                 


Phe Pro Glu Phe Leu Lys Glu Leu Ala Ala Ile Ser Gln Ala His Ala 
945                 950                 955                 960 


Val Thr Ser Pro Phe Leu Leu Glu Thr Ser Glu Glu Gly Ser Gly Pro 
                965                 970                 975     


Leu Ile Ser Gly Cys Gly Pro Leu Asn Pro 
            980                 985     


<210> 4982
<211> 2240
<212> PRT
<213> Homo sapiens

<400> 4982
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Ser Thr Lys Glu Asp Arg Arg Ser Glu Glu Lys Ala Ala Ala Met 
    530                 535                 540                 


Ala Ala Ser Lys Lys Thr Ala Pro Pro Gly Ser Ala Val Gly Lys Gln 
545                 550                 555                 560 


Pro Ala Pro Arg Asn Leu Val Pro Lys Lys Ser Ser Phe Ala Asn Val 
                565                 570                 575     


Ala Ala Ala Thr Pro Ala Ile Lys Lys Pro Pro Ser Gly Phe Lys Gly 
            580                 585                 590         


Thr Ile Pro Lys Arg Pro Trp Leu Ser Ala Thr Pro Ser Ser Gly Ala 
        595                 600                 605             


Ser Ala Ala Arg Gln Ala Gly Pro Ala Pro Ala Ala Ala Thr Ala Ala 
    610                 615                 620                 


Ser Lys Lys Phe Pro Gly Ser Ala Ala Leu Val Gly Ala Val Arg Lys 
625                 630                 635                 640 


Pro Val Val Pro Ser Val Pro Met Ala Ser Pro Ala Pro Gly Arg Leu 
                645                 650                 655     


Gly Ala Met Ser Ala Ala Pro Ser Gln Pro Asn Ser Gln Ile Arg Gln 
            660                 665                 670         


Asn Ile Arg Arg Ser Leu Lys Glu Ile Leu Trp Lys Arg Val Asn Asp 
        675                 680                 685             


Ser Asp Asp Leu Ile Met Thr Glu Asn Glu Val Gly Lys Ile Ala Leu 
    690                 695                 700                 


His Ile Glu Lys Glu Met Phe Asn Leu Phe Gln Val Thr Asp Asn Arg 
705                 710                 715                 720 


Tyr Lys Ser Lys Tyr Arg Ser Ile Met Phe Asn Leu Lys Asp Pro Lys 
                725                 730                 735     


Asn Gln Gly Leu Phe His Arg Val Leu Arg Glu Glu Ile Ser Leu Ala 
            740                 745                 750         


Lys Leu Val Arg Leu Lys Pro Glu Glu Leu Val Ser Lys Glu Leu Ser 
        755                 760                 765             


Thr Trp Lys Glu Arg Pro Ala Arg Ser Val Met Glu Ser Arg Thr Lys 
    770                 775                 780                 


Leu His Asn Glu Ser Lys Lys Thr Ala Pro Arg Gln Glu Ala Ile Pro 
785                 790                 795                 800 


Asp Leu Glu Asp Ser Pro Pro Val Ser Asp Ser Glu Glu Gln Gln Glu 
                805                 810                 815     


Ser Ala Arg Ala Val Pro Glu Lys Ser Thr Ala Pro Leu Leu Asp Val 
            820                 825                 830         


Phe Ser Ser Met Leu Lys Asp Thr Thr Ser Gln His Arg Ala His Leu 
        835                 840                 845             


Phe Asp Leu Asn Cys Lys Ile Cys Thr Gly Gln Val Pro Ser Ala Glu 
    850                 855                 860                 


Asp Glu Pro Ala Pro Lys Lys Gln Lys Leu Ser Ala Ser Val Lys Lys 
865                 870                 875                 880 


Glu Asp Leu Lys Ser Lys His Asp Ser Ser Ala Pro Asp Pro Ala Pro 
                885                 890                 895     


Asp Ser Ala Asp Glu Val Met Pro Glu Ala Val Pro Glu Val Ala Ser 
            900                 905                 910         


Glu Pro Gly Leu Glu Ser Ala Ser His Pro Asn Val Asp Arg Thr Tyr 
        915                 920                 925             


Phe Pro Gly Pro Pro Gly Asp Gly His Pro Glu Pro Ser Pro Leu Glu 
    930                 935                 940                 


Asp Leu Ser Pro Cys Pro Ala Ser Cys Gly Ser Gly Val Val Thr Thr 
945                 950                 955                 960 


Val Thr Val Ser Gly Arg Asp Pro Arg Thr Ala Pro Ser Ser Ser Cys 
                965                 970                 975     


Thr Ala Val Ala Ser Ala Ala Ser Arg Pro Asp Ser Thr His Met Val 
            980                 985                 990         


Glu Ala Arg Gln Asp Val Pro Lys  Pro Val Leu Thr Ser  Val Met Val 
        995                 1000                 1005             


Pro Lys  Ser Ile Leu Ala Lys  Pro Ser Ser Ser Pro  Asp Pro Arg 
    1010                 1015                 1020             


Tyr Leu  Ser Val Pro Pro Ser  Pro Asn Ile Ser Thr  Ser Glu Ser 
    1025                 1030                 1035             


Arg Ser  Pro Pro Glu Gly Asp  Thr Thr Leu Phe Leu  Ser Arg Leu 
    1040                 1045                 1050             


Ser Thr  Ile Trp Lys Gly Phe  Ile Asn Met Gln Ser  Val Ala Lys 
    1055                 1060                 1065             


Phe Val  Thr Lys Ala Tyr Pro  Val Ser Gly Cys Phe  Asp Tyr Leu 
    1070                 1075                 1080             


Ser Glu  Asp Leu Pro Asp Thr  Ile His Ile Gly Gly  Arg Ile Ala 
    1085                 1090                 1095             


Pro Lys  Thr Val Trp Asp Tyr  Val Gly Lys Leu Lys  Ser Ser Val 
    1100                 1105                 1110             


Ser Lys  Glu Leu Cys Leu Ile  Arg Phe His Pro Ala  Thr Glu Glu 
    1115                 1120                 1125             


Glu Glu  Val Ala Tyr Ile Ser  Leu Tyr Ser Tyr Phe  Ser Ser Arg 
    1130                 1135                 1140             


Gly Arg  Phe Gly Val Val Ala  Asn Asn Asn Arg His  Val Lys Asp 
    1145                 1150                 1155             


Leu Tyr  Leu Ile Pro Leu Ser  Ala Gln Asp Pro Val  Pro Ser Lys 
    1160                 1165                 1170             


Leu Leu  Pro Phe Glu Gly Pro  Gly Leu Glu Ser Pro  Arg Pro Asn 
    1175                 1180                 1185             


Ile Ile  Leu Gly Leu Val Ile  Cys Gln Lys Ile Lys  Arg Pro Ala 
    1190                 1195                 1200             


Asn Ser  Gly Glu Leu Asp Lys  Met Asp Glu Lys Arg  Thr Arg Leu 
    1205                 1210                 1215             


Gln Pro  Glu Glu Ala Asp Val  Pro Ala Tyr Pro Lys  Val Ala Thr 
    1220                 1225                 1230             


Val Pro  Gln Ser Glu Lys Lys  Pro Ser Lys Tyr Pro  Leu Cys Ser 
    1235                 1240                 1245             


Ala Asp  Ala Ala Val Ser Thr  Thr Pro Pro Gly Ser  Pro Pro Pro 
    1250                 1255                 1260             


Pro Pro  Pro Leu Pro Glu Pro  Pro Val Leu Lys Val  Leu Ser Ser 
    1265                 1270                 1275             


Leu Lys  Pro Ala Ala Pro Ser  Pro Ala Thr Ala Ala  Thr Thr Ala 
    1280                 1285                 1290             


Ala Ala  Ala Ser Thr Ala Ala  Ser Ser Thr Ala Ser  Ser Ala Ser 
    1295                 1300                 1305             


Lys Thr  Ala Ser Pro Leu Glu  His Ile Leu Gln Thr  Leu Phe Gly 
    1310                 1315                 1320             


Lys Lys  Lys Ser Phe Asp Pro  Ser Ala Arg Glu Pro  Pro Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gly Leu Pro Gln Glu  Pro Lys Thr Thr Ala  Glu Asp Gly 
    1340                 1345                 1350             


Val Pro  Ala Pro Pro Leu Leu  Asp Pro Ile Val Gln  Gln Phe Gly 
    1355                 1360                 1365             


Gln Phe  Ser Lys Asp Lys Ala  Leu Glu Glu Glu Glu  Asp Asp Arg 
    1370                 1375                 1380             


Pro Tyr  Asp Pro Glu Glu Glu  Tyr Asp Pro Glu Arg  Ala Phe Asp 
    1385                 1390                 1395             


Thr Gln  Leu Val Glu Arg Gly  Arg Arg His Glu Val  Glu Arg Ala 
    1400                 1405                 1410             


Pro Glu  Ala Ala Ala Ala Glu  Arg Glu Glu Val Ala  Tyr Asp Pro 
    1415                 1420                 1425             


Glu Asp  Glu Thr Ile Leu Glu  Glu Ala Lys Val Thr  Val Asp Asp 
    1430                 1435                 1440             


Leu Pro  Asn Arg Met Cys Ala  Asp Val Arg Arg Asn  Ser Val Glu 
    1445                 1450                 1455             


Arg Pro  Ala Glu Pro Val Ala  Gly Ala Ala Thr Pro  Ser Leu Val 
    1460                 1465                 1470             


Glu Gln  Gln Lys Met Leu Glu  Glu Leu Asn Lys Gln  Ile Glu Glu 
    1475                 1480                 1485             


Gln Lys  Arg Gln Leu Glu Glu  Gln Glu Glu Ala Leu  Arg Gln Gln 
    1490                 1495                 1500             


Arg Ala  Ala Val Gly Val Ser  Met Ala His Phe Ser  Val Ser Asp 
    1505                 1510                 1515             


Ala Leu  Met Ser Pro Pro Pro  Lys Ser Ser Leu Pro  Lys Ala Glu 
    1520                 1525                 1530             


Leu Phe  Gln Gln Glu Gln Gln  Ser Ala Asp Lys Pro  Ala Ser Leu 
    1535                 1540                 1545             


Pro Pro  Ala Ser Gln Ala Ser  Asn His Arg Asp Pro  Arg Gln Ala 
    1550                 1555                 1560             


Arg Arg  Leu Ala Thr Glu Thr  Gly Glu Gly Glu Gly  Glu Pro Leu 
    1565                 1570                 1575             


Ser Arg  Leu Ser Ala Arg Gly  Ala Gln Gly Ala Leu  Pro Glu Arg 
    1580                 1585                 1590             


Asp Ala  Ser Arg Gly Gly Leu  Val Gly Gln Ala Pro  Met Pro Val 
    1595                 1600                 1605             


Pro Glu  Glu Lys Glu Pro Ala  Ser Ser Pro Trp Ala  Ser Gly Glu 
    1610                 1615                 1620             


Lys Pro  Pro Ala Gly Ser Glu  Gln Asp Gly Trp Lys  Ala Glu Pro 
    1625                 1630                 1635             


Gly Glu  Gly Thr Arg Pro Ala  Thr Val Gly Asp Ser  Ser Ala Arg 
    1640                 1645                 1650             


Pro Ala  Arg Arg Val Leu Leu  Pro Thr Pro Pro Cys  Gly Ala Leu 
    1655                 1660                 1665             


Gln Pro  Gly Phe Pro Leu Gln  His Asp Gly Glu Arg  Asp Pro Phe 
    1670                 1675                 1680             


Thr Cys  Pro Gly Phe Ala Ser  Gln Asp Lys Ala Leu  Gly Ser Ala 
    1685                 1690                 1695             


Gln Tyr  Glu Asp Pro Arg Asn  Leu His Ser Ala Gly  Arg Ser Ser 
    1700                 1705                 1710             


Ser Pro  Ala Gly Glu Thr Glu  Gly Asp Arg Glu Pro  Gln Ala Arg 
    1715                 1720                 1725             


Pro Gly  Glu Gly Thr Ala Pro  Leu Pro Pro Pro Gly  Gln Lys Val 
    1730                 1735                 1740             


Gly Gly  Ser Gln Pro Pro Phe  Gln Gly Gln Arg Glu  Pro Gly Pro 
    1745                 1750                 1755             


His Ala  Leu Gly Met Ser Gly  Leu His Gly Pro Asn  Phe Pro Gly 
    1760                 1765                 1770             


Pro Arg  Gly Pro Ala Pro Pro  Phe Pro Glu Glu Asn  Ile Ala Ser 
    1775                 1780                 1785             


Asn Asp  Gly Pro Arg Gly Pro  Pro Pro Ala Arg Phe  Gly Ala Gln 
    1790                 1795                 1800             


Lys Gly  Pro Ile Pro Ser Leu  Phe Ser Gly Gln His  Gly Pro Pro 
    1805                 1810                 1815             


Pro Tyr  Gly Asp Ser Arg Gly  Pro Ser Pro Ser Tyr  Leu Gly Gly 
    1820                 1825                 1830             


Pro Arg  Gly Val Ala Pro Ser  Gln Phe Glu Glu Arg  Lys Asp Pro 
    1835                 1840                 1845             


His Gly  Glu Lys Arg Glu Phe  Gln Asp Ala Pro Tyr  Asn Glu Val 
    1850                 1855                 1860             


Thr Gly  Ala Pro Ala Gln Phe  Glu Gly Thr Glu Gln  Ala Pro Phe 
    1865                 1870                 1875             


Leu Gly  Ser Arg Gly Gly Ala  Pro Phe Gln Phe Gly  Gly Gln Arg 
    1880                 1885                 1890             


Arg Pro  Leu Leu Ser Gln Leu  Lys Gly Pro Arg Gly  Gly Pro Pro 
    1895                 1900                 1905             


Pro Ser  Gln Phe Gly Gly Gln  Arg Gly Pro Pro Pro  Gly His Phe 
    1910                 1915                 1920             


Val Gly  Pro Arg Gly Pro His  Pro Ser Gln Phe Glu  Thr Ala Arg 
    1925                 1930                 1935             


Gly Pro  His Pro Asn Gln Phe  Glu Gly Pro Arg Gly  Gln Ala Pro 
    1940                 1945                 1950             


Asn Phe  Met Pro Gly Pro Arg  Gly Ile Gln Pro Gln  Gln Phe Glu 
    1955                 1960                 1965             


Asp Gln  Arg Val His Ser Pro  Pro Arg Phe Thr Asn  Gln Arg Ala 
    1970                 1975                 1980             


Pro Ala  Pro Leu Gln Phe Gly  Gly Leu Arg Gly Ser  Ala Pro Phe 
    1985                 1990                 1995             


Ser Glu  Lys Asn Glu Gln Thr  Pro Ser Arg Phe His  Phe Gln Gly 
    2000                 2005                 2010             


Gln Ala  Pro Gln Val Met Lys  Pro Gly Pro Arg Pro  Leu Leu Glu 
    2015                 2020                 2025             


Leu Pro  Ser His Pro Pro Gln  His Arg Lys Asp Arg  Trp Glu Glu 
    2030                 2035                 2040             


Ala Gly  Pro Pro Ser Ala Leu  Ser Ser Ser Ala Pro  Gly Gln Gly 
    2045                 2050                 2055             


Pro Glu  Ala Asp Gly Gln Trp  Ala Ser Ala Asp Phe  Arg Glu Gly 
    2060                 2065                 2070             


Lys Gly  His Glu Tyr Arg Asn  Gln Thr Phe Glu Gly  Arg Gln Arg 
    2075                 2080                 2085             


Glu Arg  Phe Asp Val Gly Pro  Lys Glu Lys Pro Leu  Glu Glu Pro 
    2090                 2095                 2100             


Asp Ala  Gln Gly Arg Ala Ser  Glu Asp Arg Arg Arg  Glu Arg Glu 
    2105                 2110                 2115             


Arg Gly  Arg Asn Trp Ser Arg  Glu Arg Asp Trp Asp  Arg Pro Arg 
    2120                 2125                 2130             


Glu Trp  Asp Arg His Arg Asp  Lys Asp Ser Ser Arg  Asp Trp Asp 
    2135                 2140                 2145             


Arg Asn  Arg Glu Arg Ser Ala  Asn Arg Asp Arg Glu  Arg Glu Ala 
    2150                 2155                 2160             


Asp Arg  Gly Lys Glu Trp Asp  Arg Ser Arg Glu Arg  Ser Arg Asn 
    2165                 2170                 2175             


Arg Glu  Arg Glu Arg Asp Arg  Arg Arg Asp Arg Asp  Arg Ser Arg 
    2180                 2185                 2190             


Ser Arg  Glu Arg Asp Arg Asp  Lys Ala Arg Asp Arg  Glu Arg Gly 
    2195                 2200                 2205             


Arg Asp  Arg Lys Asp Arg Ser  Lys Ser Lys Glu Ser  Ala Arg Asp 
    2210                 2215                 2220             


Pro Lys  Pro Glu Ala Ser Arg  Ala Ser Asp Ala Gly  Thr Ala Ser 
    2225                 2230                 2235             


Gln Ala  
    2240 


<210> 4983
<211> 544
<212> PRT
<213> Homo sapiens

<400> 4983
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Cys Ser Gly Lys Tyr Ser Tyr Ser Leu His Pro Ser Leu Ile Ala 
    530                 535                 540                 


<210> 4984
<211> 387
<212> PRT
<213> Homo sapiens

<400> 4984
Met Glu Arg Pro Pro Pro Arg Ala Ala Gly Arg Asp Pro Ser Ala Leu 
1               5                   10                  15      


Arg Ala Glu Ala Pro Trp Leu Arg Ala Glu Gly Pro Gly Pro Arg Ala 
            20                  25                  30          


Ala Pro Val Thr Val Pro Thr Pro Pro Gln Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Phe Ala Gly Leu Glu Phe Ala Arg Pro Gln Glu Ser Glu Pro Arg 
    50                  55                  60                  


Ala Ser Asp Leu Gly Ala Pro Arg Thr Trp Thr Gly Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Arg Thr Pro Ser Ala His Ile Pro Val Pro Ala Gln Arg Ala Thr 
                85                  90                  95      


Pro Gly Lys Ala Arg Leu Asp Glu Val Met Ala Ala Ala Ala Leu Thr 
            100                 105                 110         


Ser Leu Ser Thr Ser Pro Leu Leu Leu Gly Ala Pro Val Ala Ala Phe 
        115                 120                 125             


Ser Pro Glu Pro Gly Leu Glu Pro Trp Lys Glu Ala Leu Val Arg Pro 
    130                 135                 140                 


Pro Gly Ser Tyr Ser Ser Ser Ser Asn Ser Gly Asp Trp Gly Trp Asp 
145                 150                 155                 160 


Leu Ala Ser Asp Gln Ser Ser Pro Ser Thr Pro Ser Pro Pro Leu Pro 
                165                 170                 175     


Pro Glu Ala Ala His Phe Leu Phe Gly Glu Pro Thr Leu Arg Lys Arg 
            180                 185                 190         


Lys Ser Pro Ala Gln Val Met Phe Gln Cys Leu Trp Lys Ser Cys Gly 
        195                 200                 205             


Lys Val Leu Ser Thr Ala Ser Ala Met Gln Arg His Ile Arg Leu Val 
    210                 215                 220                 


His Leu Gly Arg Gln Ala Glu Pro Glu Gln Ser Asp Gly Glu Glu Asp 
225                 230                 235                 240 


Phe Tyr Tyr Thr Glu Leu Asp Val Gly Val Asp Thr Leu Thr Asp Gly 
                245                 250                 255     


Leu Ser Ser Leu Thr Pro Val Ser Pro Thr Ala Ser Met Pro Pro Ala 
            260                 265                 270         


Phe Pro Arg Leu Glu Leu Pro Glu Leu Leu Glu Pro Pro Ala Leu Pro 
        275                 280                 285             


Ser Pro Leu Arg Pro Pro Ala Pro Pro Leu Pro Pro Pro Pro Val Leu 
    290                 295                 300                 


Ser Thr Val Ala Asn Pro Gln Ser Cys His Ser Asp Arg Val Tyr Gln 
305                 310                 315                 320 


Gly Cys Leu Thr Pro Ala Arg Leu Glu Pro Gln Pro Thr Glu Val Gly 
                325                 330                 335     


Ala Cys Pro Pro Ala Leu Ser Ser Arg Ile Gly Val Thr Leu Arg Lys 
            340                 345                 350         


Pro Arg Gly Asp Ala Lys Lys Cys Arg Lys Val Tyr Gly Met Glu Arg 
        355                 360                 365             


Arg Asp Leu Trp Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg 
    370                 375                 380                 


Phe Leu Asp 
385         


<210> 4985
<211> 137
<212> PRT
<213> Homo sapiens

<400> 4985
Met Leu Arg Phe Cys Ala Gly Leu Ser Asp Phe Ala Pro Val Ala Val 
1               5                   10                  15      


Arg Ser Leu Gln Asp Leu Ala Arg Ile Ala Ile Arg Gly Thr Ile Lys 
            20                  25                  30          


Lys Ile Ile His Gln Glu Thr Val Ser Lys Asn Gly Asn Gly Leu Lys 
        35                  40                  45              


Asn Thr Pro Arg Phe Lys Arg Arg Arg Val Arg Arg Arg Arg Met Glu 
    50                  55                  60                  


Thr Ile Val Phe Leu Asp Lys Glu Val Phe Ala Ser Arg Ile Ser Asn 
65                  70                  75                  80  


Pro Ser Asp Asp Asn Ser Cys Glu Asp Leu Glu Glu Glu Arg Arg Glu 
                85                  90                  95      


Glu Glu Glu Lys Thr Pro Pro Glu Thr Lys Pro Asp Pro Pro Val Asn 
            100                 105                 110         


Phe Leu Arg Gln Lys Val Leu Ser Leu Pro Leu Pro Asp Pro Leu Lys 
        115                 120                 125             


Tyr Tyr Leu Leu Tyr Tyr Arg Glu Lys 
    130                 135         


<210> 4986
<211> 834
<212> PRT
<213> Homo sapiens

<400> 4986
Met Arg Leu Leu Asp Gly Lys Gln Thr Ser Arg Tyr Ser Glu Asn Ala 
1               5                   10                  15      


Cys Glu Lys Lys Ile Phe Ser Ile Tyr Gly His Tyr Pro Val Val Arg 
            20                  25                  30          


Ala Ala Leu Arg Arg Lys Gly Trp Val Glu Lys Lys Phe His Phe Leu 
        35                  40                  45              


Pro Lys Val Ile Pro Asp Val Glu Asp Glu Gly Ala Arg Val Asn Asp 
    50                  55                  60                  


Asp Thr Cys Ala Lys Val Lys Glu Asn Gln Glu Met Ala Leu Glu Lys 
65                  70                  75                  80  


Thr Asp Asn Ile His Asp Val Met Ser Arg Leu Val Lys Asn Glu Met 
                85                  90                  95      


Pro Tyr Leu Leu Trp Thr Ile Lys Arg Asp Ile Ile Asp Tyr His Ser 
            100                 105                 110         


Leu Thr Tyr Asp Gln Met Leu Asn His Tyr Ala Lys Thr Ala Ser Phe 
        115                 120                 125             


Thr Thr Lys Ile Gly Leu Cys Val Asn Met Arg Ser Leu Pro Trp Tyr 
    130                 135                 140                 


Val Pro Ala Asn Pro Asp Ser Phe Phe Pro Arg Cys Tyr Ser Leu Cys 
145                 150                 155                 160 


Thr Glu Ser Glu Gln Gln Glu Phe Leu Glu Asp Phe Arg Arg Thr Met 
                165                 170                 175     


Ala Ser Ser Ile Leu Lys Trp Val Val Ser His Gln Ser Cys Ser Arg 
            180                 185                 190         


Ser Ser Arg Ser Lys Pro Arg Asp Gln Arg Glu Glu Ala Gly Ser Ser 
        195                 200                 205             


Asp Leu Ser Ser Arg Gln Asp Ala Glu Asn Ala Glu Ala Lys Leu Arg 
    210                 215                 220                 


Gly Leu Pro Gly Gln Leu Val Asp Ile Ala Cys Lys Val Cys Gln Ala 
225                 230                 235                 240 


Tyr Leu Gly Gln Leu Glu His Glu Asp Ile Asp Thr Ser Ala Asp Ala 
                245                 250                 255     


Val Glu Asp Leu Thr Glu Ala Glu Trp Glu Asp Leu Thr Gln Gln Tyr 
            260                 265                 270         


Tyr Ser Leu Val Gln Val Pro Leu Gly Ser Ser Ile Val Leu Cys Ile 
        275                 280                 285             


Phe Lys Ile Gln Lys Val Met Met Ser Phe Glu Pro Pro Thr Ala Arg 
    290                 295                 300                 


Asp Arg Gln Cys Gln Ala Leu Leu Asn Arg Ile Thr Ser Val Asn Pro 
305                 310                 315                 320 


Gln Thr Asp Ile Asp Gly Leu Arg Asn Ile Trp Ile Ile Lys Pro Ala 
                325                 330                 335     


Ala Lys Ser Arg Gly Arg Gly Glu Ser Pro Asp Ile Val Cys Met Asp 
            340                 345                 350         


Arg Val Glu Glu Ile Leu Glu Leu Ala Ala Ala Asp His Pro Leu Ser 
        355                 360                 365             


Arg Asp Asn Lys Trp Val Val Gln Lys Tyr Ile Glu Thr Pro Leu Leu 
    370                 375                 380                 


Ile Cys Asp Thr Lys Phe Asp Ile Arg Gln Trp Phe Leu Val Thr Asp 
385                 390                 395                 400 


Trp Asn Pro Leu Thr Ile Trp Phe Tyr Lys Glu Ser Tyr Leu Arg Phe 
                405                 410                 415     


Ser Thr Gln Arg Phe Ser Leu Asp Lys Leu Asp Ser Ala Ile His Leu 
            420                 425                 430         


Cys Asn Asn Ala Val Gln Lys Tyr Leu Lys Asn Asp Val Gly Arg Ser 
        435                 440                 445             


Pro Leu Leu Pro Ala His Asn Met Trp Thr Ser Thr Arg Phe Gln Glu 
    450                 455                 460                 


Tyr Leu Gln Arg Gln Gly Arg Gly Ala Val Trp Gly Ser Val Ile Tyr 
465                 470                 475                 480 


Pro Ser Met Lys Lys Ala Ile Ala His Ala Met Lys Val Ala Gln Asp 
                485                 490                 495     


His Val Glu Pro Arg Lys Asn Ser Phe Glu Leu Tyr Gly Ala Asp Phe 
            500                 505                 510         


Val Leu Gly Arg Asp Phe Arg Pro Trp Leu Ile Glu Ile Asn Ser Ser 
        515                 520                 525             


Pro Thr Met His Pro Ser Thr Pro Val Thr Ala Gln Leu Cys Ala Gln 
    530                 535                 540                 


Val Gln Glu Asp Thr Ile Lys Val Ala Val Asp Arg Ser Cys Asp Ile 
545                 550                 555                 560 


Gly Asn Phe Glu Leu Leu Trp Arg Gln Pro Val Val Glu Pro Pro Pro 
                565                 570                 575     


Phe Ser Gly Ser Asp Leu Cys Val Ala Gly Val Ser Val Arg Arg Ala 
            580                 585                 590         


Arg Arg Gln Val Leu Pro Val Cys Asn Leu Lys Ala Ser Ala Ser Leu 
        595                 600                 605             


Leu Asp Ala Gln Pro Leu Lys Ala Arg Gly Pro Ser Ala Met Pro Asp 
    610                 615                 620                 


Pro Ala Gln Gly Pro Pro Ser Pro Ala Leu Gln Arg Asp Leu Gly Leu 
625                 630                 635                 640 


Lys Glu Glu Lys Gly Leu Pro Leu Ala Leu Leu Ala Pro Leu Arg Gly 
                645                 650                 655     


Ala Ala Glu Ser Gly Gly Ala Ala Gln Pro Thr Arg Thr Lys Ala Ala 
            660                 665                 670         


Gly Lys Val Glu Leu Pro Ala Cys Pro Cys Arg His Val Asp Ser Gln 
        675                 680                 685             


Ala Pro Asn Thr Gly Val Pro Val Ala Gln Pro Ala Lys Ser Trp Asp 
    690                 695                 700                 


Pro Asn Gln Leu Asn Ala His Pro Leu Glu Pro Val Leu Arg Gly Leu 
705                 710                 715                 720 


Lys Thr Ala Glu Gly Ala Leu Arg Pro Pro Pro Gly Gly Lys Gly Glu 
                725                 730                 735     


Gly Thr Val Cys Ser Arg Leu Pro His His Gly His His Val Ala Ala 
            740                 745                 750         


Cys Gln Thr Thr Gly Thr Thr Trp Asp Gly Gly Pro Gly Val Cys Phe 
        755                 760                 765             


Leu Arg Gln Leu Leu Ala Ser Glu Leu Pro Met Gly Pro Gly Leu Pro 
    770                 775                 780                 


Arg Asp Pro Arg Ala Pro Pro Cys Leu Val Cys Arg Gly Leu Leu Pro 
785                 790                 795                 800 


Pro Ala Gly Pro Cys Lys Arg Cys Arg Ser Phe Cys Ala Ala Val Leu 
                805                 810                 815     


Gln Gly Ala Ser Phe Val Arg Leu Gly Gly Arg Ser Cys Ser Pro Arg 
            820                 825                 830         


Thr Pro 
        


<210> 4987
<211> 252
<212> PRT
<213> Homo sapiens

<400> 4987
Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp Asp 
1               5                   10                  15      


Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala Tyr Tyr Thr Arg 
            20                  25                  30          


His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Arg Thr Arg Ser Leu Ser Gln Arg Gly Leu Gly Asn Cys Ser Ala Asn 
    50                  55                  60                  


Glu Ser Trp Thr Glu Val Ser Trp Pro Cys Arg Asn Ser Gln Ser Ser 
65                  70                  75                  80  


Glu Lys Ala Ile Asn Leu Gly Lys Lys Lys Ser Ser Trp Lys Ala Phe 
                85                  90                  95      


Phe Gly Val Val Glu Lys Glu Asp Ser Gln Ser Thr Pro Ala Lys Val 
            100                 105                 110         


Ser Ala Gln Gly Gln Arg Thr Leu Glu Tyr Gln Asp Ser His Ser Gln 
        115                 120                 125             


Gln Trp Ser Arg Cys Leu Ser Asn Val Glu Gln Cys Leu Glu His Glu 
    130                 135                 140                 


Ala Val Asp Pro Lys Val Ile Ser Ile Ala Asn Arg Val Ala Glu Ile 
145                 150                 155                 160 


Val Tyr Ser Trp Pro Pro Pro Gln Ala Thr Gln Ala Gly Gly Phe Lys 
                165                 170                 175     


Ser Lys Glu Ile Phe Val Thr Glu Gly Leu Ser Phe Gln Leu Gln Gly 
            180                 185                 190         


His Val Pro Val Ala Ser Ser Ser Lys Lys Asp Glu Glu Glu Gln Ile 
        195                 200                 205             


Leu Ala Lys Ile Val Glu Leu Leu Lys Tyr Ser Gly Asp Gln Leu Glu 
    210                 215                 220                 


Arg Lys Asp Thr Ala Phe Ile Pro Ile Pro Leu Val Asp Thr Ser Ile 
225                 230                 235                 240 


Gln Gly Phe Pro Gln Asp Gly Leu Met Ala Cys Ile 
                245                 250         


<210> 4988
<211> 86
<212> PRT
<213> Homo sapiens

<400> 4988
Met Ser Leu Pro Leu Asn Pro Lys Pro Phe Leu Asn Gly Leu Thr Gly 
1               5                   10                  15      


Lys Pro Val Met Val Lys Leu Lys Trp Gly Met Glu Tyr Lys Gly Tyr 
            20                  25                  30          


Leu Val Ser Val Asp Gly Tyr Met Asn Met Gln Leu Ala Asn Thr Glu 
        35                  40                  45              


Glu Tyr Ile Asp Gly Ala Leu Ser Gly His Leu Gly Glu Val Leu Ile 
    50                  55                  60                  


Arg Cys Asn Asn Val Leu Tyr Ile Arg Gly Val Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Gly Glu Met Arg Glu 
                85      


<210> 4989
<211> 426
<212> PRT
<213> Homo sapiens

<400> 4989
Met Ala Ser Gly His Ser Leu Leu Leu Glu Asn Ala Gln Gln Val Val 
1               5                   10                  15      


Leu Val Cys Ala Arg Gly Glu Arg Phe Leu Ala Arg Asp Ala Leu Arg 
            20                  25                  30          


Ser Leu Ala Val Leu Glu Gly Ala Ser Leu Val Val Gly Lys Asp Gly 
        35                  40                  45              


Phe Ile Lys Ala Ile Gly Pro Ala Asp Val Ile Gln Arg Gln Phe Ser 
    50                  55                  60                  


Gly Glu Thr Phe Glu Glu Ile Ile Asp Cys Ser Gly Lys Cys Ile Leu 
65                  70                  75                  80  


Pro Gly Leu Val Asp Ala His Thr His Pro Val Trp Ala Gly Glu Arg 
                85                  90                  95      


Val His Glu Phe Ala Met Lys Leu Ala Gly Ala Thr Tyr Met Glu Ile 
            100                 105                 110         


His Gln Ala Gly Gly Gly Ile His Phe Thr Val Glu Arg Thr Arg Gln 
        115                 120                 125             


Ala Thr Glu Glu Glu Leu Phe Arg Ser Leu Gln Gln Arg Leu Gln Cys 
    130                 135                 140                 


Met Met Arg Ala Gly Thr Thr Leu Val Glu Cys Lys Ser Gly Tyr Gly 
145                 150                 155                 160 


Leu Asp Leu Glu Thr Glu Leu Lys Met Leu Arg Val Ile Glu Arg Ala 
                165                 170                 175     


Arg Arg Glu Leu Asp Ile Gly Ile Ser Ala Thr Tyr Cys Gly Ala His 
            180                 185                 190         


Ser Val Pro Lys Gly Lys Thr Ala Thr Glu Ala Ala Asp Asp Ile Ile 
        195                 200                 205             


Asn Asn His Leu Pro Lys Leu Lys Glu Leu Gly Arg Asn Gly Glu Ile 
    210                 215                 220                 


His Val Asp Asn Ile Asp Val Phe Cys Glu Lys Gly Val Phe Asp Leu 
225                 230                 235                 240 


Asp Ser Thr Arg Arg Ile Leu Gln Arg Gly Lys Asp Ile Gly Leu Gln 
                245                 250                 255     


Ile Asn Phe His Gly Asp Glu Leu His Pro Met Lys Ala Ala Glu Leu 
            260                 265                 270         


Gly Ala Glu Leu Gly Ala Gln Ala Ile Ser His Leu Glu Glu Val Ser 
        275                 280                 285             


Asp Glu Gly Ile Val Ala Met Ala Thr Ala Arg Cys Ser Ala Ile Leu 
    290                 295                 300                 


Leu Pro Thr Thr Ala Tyr Met Leu Arg Leu Lys Gln Pro Arg Ala Arg 
305                 310                 315                 320 


Lys Met Leu Asp Glu Gly Val Ile Val Ala Leu Gly Ser Asp Phe Asn 
                325                 330                 335     


Pro Asn Ala Tyr Cys Phe Ser Met Pro Met Val Met His Leu Ala Cys 
            340                 345                 350         


Val Asn Met Arg Met Ser Met Pro Glu Ala Leu Ala Ala Ala Thr Ile 
        355                 360                 365             


Asn Ala Ala Tyr Ala Leu Gly Lys Ser His Thr His Gly Ser Leu Glu 
    370                 375                 380                 


Val Gly Lys Gln Gly Asp Leu Ile Ile Ile Asn Ser Ser Arg Trp Glu 
385                 390                 395                 400 


His Leu Ile Tyr Gln Phe Gly Gly His His Glu Leu Ile Glu Tyr Val 
                405                 410                 415     


Ile Ala Lys Gly Lys Leu Ile Tyr Lys Thr 
            420                 425     


<210> 4990
<211> 420
<212> PRT
<213> Homo sapiens

<400> 4990
Met Phe Ser Pro Gly Gln Glu Glu His Cys Ala Pro Asn Lys Glu Pro 
1               5                   10                  15      


Val Lys Tyr Gly Glu Leu Val Val Leu Gly Tyr Asn Gly Ala Leu Pro 
            20                  25                  30          


Asn Gly Asp Arg Gly Arg Arg Lys Ser Arg Phe Ala Leu Tyr Lys Arg 
        35                  40                  45              


Pro Lys Ala Asn Gly Val Lys Pro Ser Thr Val His Val Ile Ser Thr 
    50                  55                  60                  


Pro Gln Ala Ser Lys Ala Ile Ser Cys Lys Gly Gln His Ser Ile Ser 
65                  70                  75                  80  


Tyr Thr Leu Ser Arg Asn Gln Thr Val Val Val Glu Tyr Thr His Asp 
                85                  90                  95      


Lys Asp Thr Asp Met Phe Gln Val Gly Arg Ser Thr Glu Ser Pro Ile 
            100                 105                 110         


Asp Phe Val Val Thr Asp Thr Ile Ser Gly Ser Gln Asn Thr Asp Glu 
        115                 120                 125             


Ala Gln Ile Thr Gln Ser Thr Ile Ser Arg Phe Ala Cys Arg Ile Val 
    130                 135                 140                 


Cys Asp Arg Asn Glu Pro Tyr Thr Ala Arg Ile Phe Ala Ala Gly Phe 
145                 150                 155                 160 


Asp Ser Ser Lys Asn Ile Phe Leu Gly Glu Lys Ala Ala Lys Trp Lys 
                165                 170                 175     


Asn Pro Asp Gly His Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val 
            180                 185                 190         


Met His Pro Arg Gly Gly Phe Thr Glu Glu Ser Gln Pro Gly Val Trp 
        195                 200                 205             


Arg Glu Ile Ser Val Cys Gly Asp Val Tyr Thr Leu Arg Glu Thr Arg 
    210                 215                 220                 


Ser Ala Gln Gln Arg Gly Lys Leu Val Glu Ser Glu Thr Asn Val Leu 
225                 230                 235                 240 


Gln Asp Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg 
                245                 250                 255     


Thr Ala Asp Gly Leu Phe His Thr Pro Thr Gln Lys His Ile Glu Ala 
            260                 265                 270         


Leu Arg Gln Glu Ile Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Leu 
        275                 280                 285             


Asn Thr Leu Ala Phe Pro Ser Ile Asn Arg Lys Glu Val Val Glu Glu 
    290                 295                 300                 


Lys Gln Pro Trp Ala Tyr Leu Ser Cys Gly His Val His Gly Tyr His 
305                 310                 315                 320 


Asn Trp Gly His Arg Ser Asp Thr Glu Ala Asn Glu Arg Glu Cys Pro 
                325                 330                 335     


Met Cys Arg Thr Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Cys Glu 
            340                 345                 350         


Ala Gly Phe Tyr Val Asp Ala Gly Pro Pro Thr His Ala Phe Thr Pro 
        355                 360                 365             


Cys Gly His Val Cys Ser Glu Lys Ser Ala Lys Tyr Trp Ser Gln Ile 
    370                 375                 380                 


Pro Leu Pro His Gly Thr His Ala Phe His Ala Ala Cys Pro Phe Cys 
385                 390                 395                 400 


Ala Thr Gln Leu Val Gly Glu Gln Asn Cys Ile Lys Leu Ile Phe Gln 
                405                 410                 415     


Gly Pro Ile Asp 
            420 


<210> 4991
<211> 351
<212> PRT
<213> Homo sapiens

<400> 4991
Met Ile Val Gln Arg Val Val Leu Asn Ser Arg Pro Gly Lys Asn Gly 
1               5                   10                  15      


Asn Pro Val Ala Glu Asn Phe Arg Met Glu Glu Val Tyr Leu Pro Asp 
            20                  25                  30          


Asn Ile Asn Glu Gly Gln Val Gln Val Arg Thr Leu Tyr Leu Ser Val 
        35                  40                  45              


Asp Pro Tyr Met Arg Cys Arg Met Asn Glu Asp Thr Gly Thr Asp Tyr 
    50                  55                  60                  


Ile Thr Pro Trp Gln Leu Ser Gln Val Val Asp Gly Gly Gly Ile Gly 
65                  70                  75                  80  


Ile Ile Glu Glu Ser Lys His Thr Asn Leu Thr Lys Gly Asp Phe Val 
                85                  90                  95      


Thr Ser Phe Tyr Trp Pro Trp Gln Thr Lys Val Ile Leu Asp Gly Asn 
            100                 105                 110         


Ser Leu Glu Lys Val Asp Pro Gln Leu Val Asp Gly His Leu Ser Tyr 
        115                 120                 125             


Phe Leu Gly Ala Ile Gly Met Pro Gly Leu Thr Ser Leu Ile Gly Ile 
    130                 135                 140                 


Gln Glu Lys Gly His Ile Thr Ala Gly Ser Asn Lys Thr Met Val Val 
145                 150                 155                 160 


Ser Gly Ala Ala Gly Ala Cys Gly Ser Val Ala Gly Gln Ile Gly His 
                165                 170                 175     


Phe Leu Gly Cys Ser Arg Val Val Gly Ile Cys Gly Thr His Glu Lys 
            180                 185                 190         


Cys Ile Leu Leu Thr Ser Glu Leu Gly Phe Asp Ala Ala Ile Asn Tyr 
        195                 200                 205             


Lys Lys Asp Asn Val Ala Glu Gln Leu Arg Glu Ser Cys Pro Ala Gly 
    210                 215                 220                 


Val Asp Val Tyr Phe Asp Asn Val Gly Gly Asn Ile Ser Asp Thr Val 
225                 230                 235                 240 


Ile Ser Gln Met Asn Glu Asn Ser His Ile Ile Leu Cys Gly Gln Ile 
                245                 250                 255     


Ser Gln Tyr Asn Lys Asp Val Pro Tyr Pro Pro Pro Leu Ser Pro Ala 
            260                 265                 270         


Ile Glu Ala Ile Gln Lys Glu Arg Asn Ile Thr Arg Glu Arg Phe Leu 
        275                 280                 285             


Val Leu Asn Tyr Lys Asp Lys Phe Glu Pro Gly Ile Leu Gln Leu Ser 
    290                 295                 300                 


Gln Trp Phe Lys Glu Gly Lys Leu Lys Ile Lys Glu Thr Val Ile Asn 
305                 310                 315                 320 


Gly Leu Glu Asn Met Gly Ala Ala Phe Gln Ser Met Met Thr Gly Gly 
                325                 330                 335     


Asn Ile Gly Lys Gln Ile Val Cys Ile Ser Glu Glu Ile Ser Leu 
            340                 345                 350     


<210> 4992
<211> 723
<212> PRT
<213> Homo sapiens

<400> 4992
Met Ala Glu Glu Glu Glu Thr Ala Ala Leu Thr Glu Lys Val Ile Arg 
1               5                   10                  15      


Thr Gln Arg Val Phe Ile Asn Leu Leu Asp Ser Tyr Ser Ser Gly Asn 
            20                  25                  30          


Ile Gly Lys Phe Leu Ser Asn Cys Val Val Gly Ala Ser Leu Glu Glu 
        35                  40                  45              


Ile Thr Glu Glu Glu Glu Glu Glu Asp Glu Asn Lys Ser Ala Met Leu 
    50                  55                  60                  


Glu Ala Ser Ser Thr Lys Val Lys Glu Gly Thr Phe Gln Ile Val Gly 
65                  70                  75                  80  


Thr Leu Ser Lys Pro Asp Ser Pro Arg Pro Asp Phe Ala Val Glu Thr 
                85                  90                  95      


Tyr Ser Ala Ile Ser Arg Glu Asp Leu Leu Met Arg Leu Leu Glu Cys 
            100                 105                 110         


Asp Val Ile Ile Tyr Asn Ile Thr Glu Ser Ser Gln Gln Met Glu Glu 
        115                 120                 125             


Ala Ile Trp Ala Val Ser Ala Leu Ser Glu Glu Val Ser His Phe Glu 
    130                 135                 140                 


Lys Arg Lys Leu Phe Ile Leu Leu Ser Thr Val Met Thr Trp Ala Arg 
145                 150                 155                 160 


Ser Lys Ala Leu Asp Pro Glu Asp Ser Glu Val Pro Phe Thr Glu Glu 
                165                 170                 175     


Asp Tyr Arg Arg Arg Lys Ser His Pro Asn Phe Leu Asp His Ile Asn 
            180                 185                 190         


Ala Glu Lys Met Val Leu Lys Phe Gly Lys Lys Ala Arg Lys Phe Ala 
        195                 200                 205             


Ala Tyr Val Val Ala Ala Gly Leu Gln Tyr Gly Ala Glu Gly Gly Met 
    210                 215                 220                 


Leu His Thr Phe Phe Lys Met Ala Trp Leu Gly Glu Ile Pro Ala Leu 
225                 230                 235                 240 


Pro Val Phe Gly Asp Gly Thr Asn Val Ile Pro Thr Ile His Val Leu 
                245                 250                 255     


Asp Leu Ala Gly Val Ile Gln Asn Val Ile Asp His Val Pro Lys Pro 
            260                 265                 270         


His Tyr Leu Val Ala Val Asp Glu Ser Val His Thr Leu Glu Asp Ile 
        275                 280                 285             


Val Lys Cys Ile Ser Lys Asn Thr Gly Pro Gly Lys Ile Gln Lys Ile 
    290                 295                 300                 


Pro Arg Glu Asn Ala Tyr Leu Thr Lys Asp Leu Thr Gln Asp Cys Leu 
305                 310                 315                 320 


Asp His Leu Leu Val Asn Leu Arg Met Glu Ala Leu Phe Val Lys Glu 
                325                 330                 335     


Asn Phe Asn Ile Arg Trp Ala Ala Gln Thr Gly Phe Val Glu Asn Ile 
            340                 345                 350         


Asn Thr Ile Leu Lys Glu Tyr Lys Gln Ser Arg Gly Leu Met Pro Ile 
        355                 360                 365             


Lys Ile Cys Ile Leu Gly Pro Pro Ala Val Gly Lys Ser Ser Ile Ala 
    370                 375                 380                 


Lys Glu Leu Ala Asn Tyr Tyr Lys Leu His His Ile Gln Leu Lys Asp 
385                 390                 395                 400 


Val Ile Ser Glu Ala Ile Ala Lys Leu Glu Ala Ile Val Ala Pro Asn 
                405                 410                 415     


Asp Val Gly Glu Gly Glu Glu Glu Val Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Asn Val Glu Asp Ala Gln Glu Leu Leu Asp Gly Ile Lys Glu Ser Met 
        435                 440                 445             


Glu Gln Asn Ala Gly Gln Leu Asp Asp Gln Tyr Ile Ile Arg Phe Met 
    450                 455                 460                 


Lys Glu Lys Leu Lys Ser Met Pro Cys Arg Asn Gln Gly Tyr Ile Leu 
465                 470                 475                 480 


Asp Gly Phe Pro Lys Thr Tyr Asp Gln Ala Lys Asp Leu Phe Asn Gln 
                485                 490                 495     


Glu Asp Glu Glu Glu Glu Asp Asp Val Arg Gly Arg Met Phe Pro Phe 
            500                 505                 510         


Asp Lys Leu Ile Ile Pro Glu Phe Val Cys Ala Leu Asp Ala Ser Asp 
        515                 520                 525             


Glu Phe Leu Lys Glu Arg Val Ile Asn Leu Pro Glu Ser Ile Val Ala 
    530                 535                 540                 


Gly Thr His Tyr Ser Gln Asp Arg Phe Leu Arg Ala Leu Ser Asn Tyr 
545                 550                 555                 560 


Arg Asp Ile Asn Ile Asp Asp Glu Thr Val Phe Asn Tyr Phe Asp Glu 
                565                 570                 575     


Leu Glu Ile His Pro Ile His Ile Asp Val Gly Lys Leu Glu Asp Ala 
            580                 585                 590         


Gln Asn Arg Leu Ala Ile Lys Gln Leu Ile Lys Glu Ile Gly Glu Pro 
        595                 600                 605             


Arg Asn Tyr Gly Leu Thr Asp Glu Glu Lys Ala Glu Glu Glu Arg Lys 
    610                 615                 620                 


Ala Ala Glu Glu Arg Leu Ala Arg Glu Ala Ala Glu Glu Ala Glu Arg 
625                 630                 635                 640 


Glu His Gln Glu Ala Val Glu Met Ala Glu Lys Ile Ala Arg Trp Glu 
                645                 650                 655     


Glu Trp Asn Lys Arg Leu Glu Glu Val Lys Arg Glu Glu Arg Glu Leu 
            660                 665                 670         


Leu Glu Ala Gln Ser Ile Pro Leu Arg Asn Tyr Leu Met Thr Tyr Val 
        675                 680                 685             


Met Pro Thr Leu Ile Gln Gly Leu Asn Glu Cys Cys Asn Val Arg Pro 
    690                 695                 700                 


Glu Asp Pro Val Asp Phe Leu Ala Glu Tyr Leu Phe Lys Asn Asn Pro 
705                 710                 715                 720 


Glu Ala Gln 
            


<210> 4993
<211> 414
<212> PRT
<213> Homo sapiens

<400> 4993
Met Gln Thr Phe Leu Lys Gly Lys Arg Val Gly Tyr Trp Leu Ser Glu 
1               5                   10                  15      


Lys Lys Ile Lys Lys Leu Asn Phe Gln Ala Phe Ala Glu Leu Cys Arg 
            20                  25                  30          


Lys Arg Gly Met Glu Val Val Gln Leu Asn Leu Ser Arg Pro Ile Glu 
        35                  40                  45              


Glu Gln Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile 
    50                  55                  60                  


Leu Glu Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg 
65                  70                  75                  80  


Phe Gln Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro 
                85                  90                  95      


Leu Pro Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu 
            100                 105                 110         


Ile Arg Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro 
        115                 120                 125             


Pro Phe Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu 
    130                 135                 140                 


Leu Glu Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val 
145                 150                 155                 160 


Ala His Gly Thr Asn Ser His Glu Met Ala Ile Val Phe Asn Gln Glu 
                165                 170                 175     


Gly Leu Asn Ala Ile Gln Pro Pro Cys Val Val Gln Asn Phe Ile Asn 
            180                 185                 190         


His Asn Ala Val Leu Tyr Lys Val Phe Val Val Gly Glu Ser Tyr Thr 
        195                 200                 205             


Val Val Gln Arg Pro Ser Leu Lys Asn Phe Ser Ala Gly Thr Ser Asp 
    210                 215                 220                 


Arg Glu Ser Ile Phe Phe Asn Ser His Asn Val Ser Lys Pro Glu Ser 
225                 230                 235                 240 


Ser Ser Val Leu Thr Glu Leu Asp Lys Ile Glu Gly Val Phe Glu Arg 
                245                 250                 255     


Pro Ser Asp Glu Val Ile Arg Glu Leu Ser Arg Ala Leu Arg Gln Ala 
            260                 265                 270         


Leu Gly Val Ser Leu Phe Gly Ile Asp Ile Ile Ile Asn Asn Gln Thr 
        275                 280                 285             


Gly Gln His Ala Val Ile Asp Ile Asn Ala Phe Pro Gly Tyr Glu Gly 
    290                 295                 300                 


Val Ser Glu Phe Phe Thr Asp Leu Leu Asn His Ile Ala Thr Val Leu 
305                 310                 315                 320 


Gln Gly Gln Ser Thr Ala Met Ala Ala Thr Gly Asp Val Ala Leu Leu 
                325                 330                 335     


Arg His Ser Lys Leu Leu Ala Glu Pro Ala Gly Gly Leu Val Gly Glu 
            340                 345                 350         


Arg Thr Cys Ser Ala Ser Pro Gly Cys Cys Gly Ser Met Met Gly Gln 
        355                 360                 365             


Asp Ala Pro Trp Lys Ala Glu Ala Asp Ala Gly Gly Thr Ala Lys Leu 
    370                 375                 380                 


Pro His Gln Arg Leu Gly Cys Asn Ala Gly Val Ser Pro Ser Phe Gln 
385                 390                 395                 400 


Gln His Cys Val Ala Ser Leu Ala Thr Lys Ala Ser Ser Gln 
                405                 410                 


<210> 4994
<211> 199
<212> PRT
<213> Homo sapiens

<400> 4994
Met Arg Phe Arg Phe Cys Gly Asp Leu Asp Cys Pro Asp Trp Val Leu 
1               5                   10                  15      


Ala Glu Ile Ser Thr Leu Ala Lys Met Ser Ser Val Lys Leu Arg Leu 
            20                  25                  30          


Leu Cys Ser Gln Val Leu Lys Glu Leu Leu Gly Gln Gly Ile Asp Tyr 
        35                  40                  45              


Glu Lys Ile Leu Lys Leu Thr Ala Asp Ala Lys Phe Glu Ser Gly Asp 
    50                  55                  60                  


Val Lys Ala Thr Val Ala Val Leu Ser Phe Ile Leu Ser Ser Ala Ala 
65                  70                  75                  80  


Lys His Ser Val Asp Gly Glu Ser Leu Ser Ser Glu Leu Gln Gln Leu 
                85                  90                  95      


Gly Leu Pro Lys Glu His Ala Ala Ser Leu Cys Arg Cys Tyr Glu Glu 
            100                 105                 110         


Lys Gln Ser Pro Leu Gln Lys His Leu Arg Val Cys Ser Leu Arg Met 
        115                 120                 125             


Asn Arg Leu Ala Gly Val Gly Trp Arg Val Asp Tyr Thr Leu Ser Ser 
    130                 135                 140                 


Ser Leu Leu Gln Ser Val Glu Glu Pro Met Val His Leu Arg Leu Glu 
145                 150                 155                 160 


Val Ala Ala Ala Pro Gly Thr Pro Ala Gln Pro Val Ala Met Ser Leu 
                165                 170                 175     


Ser Ala Asp Lys Phe Gln Val Leu Leu Ala Glu Leu Lys Gln Ala Gln 
            180                 185                 190         


Thr Leu Met Ser Ser Leu Gly 
        195                 


<210> 4995
<211> 407
<212> PRT
<213> Homo sapiens

<400> 4995
Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly His Leu Gly Phe 
1               5                   10                  15      


Leu Pro His Lys Arg Ser His Arg His Arg Gly Lys Val Lys Thr Trp 
            20                  25                  30          


Pro Arg Asp Asp Pro Ser Gln Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45              


Tyr Lys Ala Gly Met Thr His Thr Leu Arg Glu Val His Arg Pro Gly 
    50                  55                  60                  


Leu Lys Ile Ser Lys Arg Glu Glu Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80  


Thr Pro Pro Leu Val Val Val Gly Val Val Gly Tyr Val Ala Thr Pro 
                85                  90                  95      


Arg Gly Leu Arg Ser Phe Lys Thr Ile Phe Ala Glu His Leu Ser Asp 
            100                 105                 110         


Glu Cys Arg Arg Arg Phe Tyr Lys Asp Trp His Lys Ser Lys Lys Lys 
        115                 120                 125             


Ala Phe Thr Lys Ala Cys Lys Arg Trp Arg Asp Thr Asp Gly Lys Lys 
    130                 135                 140                 


Gln Leu Gln Lys Asp Phe Ala Ala Met Lys Lys Tyr Cys Lys Val Ile 
145                 150                 155                 160 


Arg Val Ile Val His Thr Gln Met Lys Leu Leu Pro Phe Arg Gln Lys 
                165                 170                 175     


Lys Ala His Ile Met Glu Ile Gln Leu Asn Gly Gly Thr Val Ala Glu 
            180                 185                 190         


Lys Val Ala Trp Ala Gln Ala Arg Leu Glu Lys Gln Val Pro Val His 
        195                 200                 205             


Ser Val Phe Ser Gln Ser Glu Val Ile Asp Val Ile Ala Val Thr Lys 
    210                 215                 220                 


Gly Arg Gly Val Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu 
225                 230                 235                 240 


Pro Arg Lys Thr His Lys Gly Leu Arg Lys Val Ala Cys Ile Gly Ala 
                245                 250                 255     


Trp His Pro Ala Arg Val Gly Cys Ser Ile Ala Arg Ala Gly Gln Lys 
            260                 265                 270         


Gly Tyr His His Arg Thr Glu Leu Asn Lys Lys Ile Phe Arg Ile Gly 
        275                 280                 285             


Arg Gly Pro His Met Glu Asp Gly Lys Leu Val Lys Asn Asn Ala Ser 
    290                 295                 300                 


Thr Ser Tyr Asp Val Thr Ala Lys Ser Ile Thr Pro Leu Gly Gly Phe 
305                 310                 315                 320 


Pro His Tyr Gly Glu Val Asn Asn Asp Phe Val Met Leu Lys Gly Cys 
                325                 330                 335     


Ile Ala Gly Thr Lys Lys Arg Val Ile Thr Leu Arg Lys Ser Leu Leu 
            340                 345                 350         


Val His His Ser Arg Gln Ala Val Glu Asn Ile Glu Leu Lys Phe Ile 
        355                 360                 365             


Asp Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Ala Gln Glu 
    370                 375                 380                 


Lys Arg Ala Phe Met Gly Pro Gln Lys Lys His Leu Glu Lys Glu Thr 
385                 390                 395                 400 


Pro Glu Thr Ser Gly Asp Leu 
                405         


<210> 4996
<211> 2440
<212> PRT
<213> Homo sapiens

<400> 4996
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 
        35                  40                  45              


Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 
65                  70                  75                  80  


Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 
                85                  90                  95      


Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 
            100                 105                 110         


Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro 
        115                 120                 125             


Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys 
    130                 135                 140                 


Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile 
145                 150                 155                 160 


Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu 
                165                 170                 175     


Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile 
            180                 185                 190         


Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln 
        195                 200                 205             


Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser 
    210                 215                 220                 


Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr 
225                 230                 235                 240 


Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly 
                245                 250                 255     


Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr 
            260                 265                 270         


Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met Arg Lys Lys 
        275                 280                 285             


Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys Gln Arg Glu 
    290                 295                 300                 


Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala Trp Glu Lys 
305                 310                 315                 320 


Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala Lys Glu Ser 
                325                 330                 335     


Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile Arg Lys Gln 
            340                 345                 350         


Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg Gly Ala Gly 
        355                 360                 365             


Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser Glu Ile Ile 
    370                 375                 380                 


Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met Arg Gln Leu 
385                 390                 395                 400 


Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg Arg Val Lys 
                405                 410                 415     


Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys Val Tyr Lys 
            420                 425                 430         


Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys Glu Ile Phe 
        435                 440                 445             


Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu Ile Ala Ser 
    450                 455                 460                 


Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr Tyr Tyr Leu 
465                 470                 475                 480 


Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg Asn Tyr Gly 
                485                 490                 495     


Lys Arg Arg Gly Arg Asn Gln Gln Ile Ala Arg Pro Ser Gln Glu Glu 
            500                 505                 510         


Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr Glu Lys Lys 
        515                 520                 525             


Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys Glu Asp Ser 
    530                 535                 540                 


Lys Glu Asn Thr Lys Glu Lys Asp Lys Ile Asp Gly Thr Ala Glu Glu 
545                 550                 555                 560 


Thr Glu Glu Arg Glu Gln Ala Thr Pro Arg Gly Arg Lys Thr Ala Asn 
                565                 570                 575     


Ser Gln Gly Arg Arg Lys Gly Arg Ile Thr Arg Ser Met Thr Asn Glu 
            580                 585                 590         


Ala Ala Ala Ala Ser Ala Ala Ala Ala Ala Ala Thr Glu Glu Pro Pro 
        595                 600                 605             


Pro Pro Leu Pro Pro Pro Pro Glu Pro Ile Ser Thr Glu Pro Val Glu 
    610                 615                 620                 


Thr Ser Arg Trp Thr Glu Glu Glu Met Glu Val Ala Lys Lys Gly Leu 
625                 630                 635                 640 


Val Glu His Gly Arg Asn Trp Ala Ala Ile Ala Lys Met Val Gly Thr 
                645                 650                 655     


Lys Ser Glu Ala Gln Cys Lys Asn Phe Tyr Phe Asn Tyr Lys Arg Arg 
            660                 665                 670         


His Asn Leu Asp Asn Leu Leu Gln Gln His Lys Gln Lys Thr Ser Arg 
        675                 680                 685             


Lys Pro Arg Glu Glu Arg Asp Val Ser Gln Cys Glu Ser Val Ala Ser 
    690                 695                 700                 


Thr Val Ser Ala Gln Glu Asp Glu Asp Ile Glu Ala Ser Asn Glu Glu 
705                 710                 715                 720 


Glu Asn Pro Glu Asp Ser Glu Val Glu Ala Val Lys Pro Ser Glu Asp 
                725                 730                 735     


Ser Pro Glu Asn Ala Thr Ser Arg Gly Asn Thr Glu Pro Ala Val Glu 
            740                 745                 750         


Leu Glu Pro Thr Thr Glu Thr Ala Pro Ser Thr Ser Pro Ser Leu Ala 
        755                 760                 765             


Val Pro Ser Thr Lys Pro Ala Glu Asp Glu Ser Val Glu Thr Gln Val 
    770                 775                 780                 


Asn Asp Ser Ile Ser Ala Glu Thr Ala Glu Gln Met Asp Val Asp Gln 
785                 790                 795                 800 


Gln Glu His Ser Ala Glu Glu Gly Ser Val Cys Asp Pro Pro Pro Ala 
                805                 810                 815     


Thr Lys Ala Asp Ser Val Asp Val Glu Val Arg Val Pro Glu Asn His 
            820                 825                 830         


Ala Ser Lys Val Glu Gly Asp Asn Thr Lys Glu Arg Asp Leu Asp Arg 
        835                 840                 845             


Ala Ser Glu Lys Val Glu Pro Arg Asp Glu Asp Leu Val Val Ala Gln 
    850                 855                 860                 


Gln Ile Asn Ala Gln Arg Pro Glu Pro Gln Ser Asp Asn Asp Ser Ser 
865                 870                 875                 880 


Ala Thr Cys Ser Ala Asp Glu Asp Val Asp Gly Glu Pro Glu Arg Gln 
                885                 890                 895     


Arg Met Phe Pro Met Asp Ser Lys Pro Ser Leu Leu Asn Pro Thr Gly 
            900                 905                 910         


Ser Ile Leu Val Ser Ser Pro Leu Lys Pro Asn Pro Leu Asp Leu Pro 
        915                 920                 925             


Gln Leu Gln His Arg Ala Ala Val Ile Pro Pro Met Val Ser Cys Thr 
    930                 935                 940                 


Pro Cys Asn Ile Pro Ile Gly Thr Pro Val Ser Gly Tyr Ala Leu Tyr 
945                 950                 955                 960 


Gln Arg His Ile Lys Ala Met His Glu Ser Ala Leu Leu Glu Glu Gln 
                965                 970                 975     


Arg Gln Arg Gln Glu Gln Ile Asp Leu Glu Cys Arg Ser Ser Thr Ser 
            980                 985                 990         


Pro Cys Gly Thr Ser Lys Ser Pro  Asn Arg Glu Trp Glu  Val Leu Gln 
        995                 1000                 1005             


Pro Ala  Pro His Gln Val Ile  Thr Asn Leu Pro Glu  Gly Val Arg 
    1010                 1015                 1020             


Leu Pro  Thr Thr Arg Pro Thr  Arg Pro Pro Pro Pro  Leu Ile Pro 
    1025                 1030                 1035             


Ser Ser  Lys Thr Thr Val Ala  Ser Glu Lys Pro Ser  Phe Ile Met 
    1040                 1045                 1050             


Gly Gly  Ser Ile Ser Gln Gly  Thr Pro Gly Thr Tyr  Leu Thr Ser 
    1055                 1060                 1065             


His Asn  Gln Ala Ser Tyr Thr  Gln Glu Thr Pro Lys  Pro Ser Val 
    1070                 1075                 1080             


Gly Ser  Ile Ser Leu Gly Leu  Pro Arg Gln Gln Glu  Ser Ala Lys 
    1085                 1090                 1095             


Ser Ala  Thr Leu Pro Tyr Ile  Lys Gln Glu Glu Phe  Ser Pro Arg 
    1100                 1105                 1110             


Ser Gln  Asn Ser Gln Pro Glu  Gly Leu Leu Val Arg  Ala Gln His 
    1115                 1120                 1125             


Glu Gly  Val Val Arg Gly Thr  Ala Gly Ala Ile Gln  Glu Gly Ser 
    1130                 1135                 1140             


Ile Thr  Arg Gly Thr Pro Thr  Ser Lys Ile Ser Val  Glu Ser Ile 
    1145                 1150                 1155             


Pro Ser  Leu Arg Gly Ser Ile  Thr Gln Gly Thr Pro  Ala Leu Pro 
    1160                 1165                 1170             


Gln Thr  Gly Ile Pro Thr Glu  Ala Leu Val Lys Gly  Ser Ile Ser 
    1175                 1180                 1185             


Arg Met  Pro Ile Glu Asp Ser  Ser Pro Glu Lys Gly  Arg Glu Glu 
    1190                 1195                 1200             


Ala Ala  Ser Lys Gly His Val  Ile Tyr Glu Gly Lys  Ser Gly His 
    1205                 1210                 1215             


Ile Leu  Ser Tyr Asp Asn Ile  Lys Asn Ala Arg Glu  Gly Thr Arg 
    1220                 1225                 1230             


Ser Pro  Arg Thr Ala His Glu  Ile Ser Leu Lys Arg  Ser Tyr Glu 
    1235                 1240                 1245             


Ser Val  Glu Gly Asn Ile Lys  Gln Gly Met Ser Met  Arg Glu Ser 
    1250                 1255                 1260             


Pro Val  Ser Ala Pro Leu Glu  Gly Leu Ile Cys Arg  Ala Leu Pro 
    1265                 1270                 1275             


Arg Gly  Ser Pro His Ser Asp  Leu Lys Glu Arg Thr  Val Leu Ser 
    1280                 1285                 1290             


Gly Ser  Ile Met Gln Gly Thr  Pro Arg Ala Thr Thr  Glu Ser Phe 
    1295                 1300                 1305             


Glu Asp  Gly Leu Lys Tyr Pro  Lys Gln Ile Lys Arg  Glu Ser Pro 
    1310                 1315                 1320             


Pro Ile  Arg Ala Phe Glu Gly  Ala Ile Thr Lys Gly  Lys Pro Tyr 
    1325                 1330                 1335             


Asp Gly  Ile Thr Thr Ile Lys  Glu Met Gly Arg Ser  Ile His Glu 
    1340                 1345                 1350             


Ile Pro  Arg Gln Asp Ile Leu  Thr Gln Glu Ser Arg  Lys Thr Pro 
    1355                 1360                 1365             


Glu Val  Val Gln Ser Thr Arg  Pro Ile Ile Glu Gly  Ser Ile Ser 
    1370                 1375                 1380             


Gln Gly  Thr Pro Ile Lys Phe  Asp Asn Asn Ser Gly  Gln Ser Ala 
    1385                 1390                 1395             


Ile Lys  His Asn Val Lys Ser  Leu Ile Thr Gly Pro  Ser Lys Leu 
    1400                 1405                 1410             


Ser Arg  Gly Met Pro Pro Leu  Glu Ile Val Pro Glu  Asn Ile Lys 
    1415                 1420                 1425             


Val Val  Glu Arg Gly Lys Tyr  Glu Asp Val Lys Ala  Gly Glu Thr 
    1430                 1435                 1440             


Val Arg  Ser Arg His Thr Ser  Val Val Ser Ser Gly  Pro Ser Val 
    1445                 1450                 1455             


Leu Arg  Ser Thr Leu His Glu  Ala Pro Lys Ala Gln  Leu Ser Pro 
    1460                 1465                 1470             


Gly Ile  Tyr Asp Asp Thr Ser  Ala Arg Arg Thr Pro  Val Ser Tyr 
    1475                 1480                 1485             


Gln Asn  Thr Met Ser Arg Gly  Ser Pro Met Met Asn  Arg Thr Ser 
    1490                 1495                 1500             


Asp Val  Thr Ile Ser Ser Asn  Lys Ser Thr Asn His  Glu Arg Lys 
    1505                 1510                 1515             


Ser Thr  Leu Thr Pro Thr Gln  Arg Glu Ser Ile Pro  Ala Lys Ser 
    1520                 1525                 1530             


Pro Val  Pro Gly Val Asp Pro  Val Val Ser His Ser  Pro Phe Asp 
    1535                 1540                 1545             


Pro His  His Arg Gly Ser Thr  Ala Gly Glu Val Tyr  Arg Ser His 
    1550                 1555                 1560             


Leu Pro  Thr His Leu Asp Pro  Ala Met Pro Phe His  Arg Ala Leu 
    1565                 1570                 1575             


Asp Pro  Ala Ala Ala Ala Tyr  Leu Phe Gln Arg Gln  Leu Ser Pro 
    1580                 1585                 1590             


Thr Pro  Gly Tyr Pro Ser Gln  Tyr Gln Leu Tyr Ala  Met Glu Asn 
    1595                 1600                 1605             


Thr Arg  Gln Thr Ile Leu Asn  Asp Tyr Ile Thr Ser  Gln Gln Met 
    1610                 1615                 1620             


Gln Val  Asn Leu Arg Pro Asp  Val Ala Arg Gly Leu  Ser Pro Arg 
    1625                 1630                 1635             


Glu Gln  Pro Leu Gly Leu Pro  Tyr Pro Ala Thr Arg  Gly Ile Ile 
    1640                 1645                 1650             


Asp Leu  Thr Asn Met Pro Pro  Thr Ile Leu Val Pro  His Pro Gly 
    1655                 1660                 1665             


Gly Thr  Ser Thr Pro Pro Met  Asp Arg Ile Thr Tyr  Ile Pro Gly 
    1670                 1675                 1680             


Thr Gln  Ile Thr Phe Pro Pro  Arg Pro Tyr Asn Ser  Ala Ser Met 
    1685                 1690                 1695             


Ser Pro  Gly His Pro Thr His  Leu Ala Ala Ala Ala  Ser Ala Glu 
    1700                 1705                 1710             


Arg Glu  Arg Glu Arg Glu Arg  Glu Lys Glu Arg Glu  Arg Glu Arg 
    1715                 1720                 1725             


Ile Ala  Ala Ala Ser Ser Asp  Leu Tyr Leu Arg Pro  Gly Ser Glu 
    1730                 1735                 1740             


Gln Pro  Gly Arg Pro Gly Ser  His Gly Tyr Val Arg  Ser Pro Ser 
    1745                 1750                 1755             


Pro Ser  Val Arg Thr Gln Glu  Thr Met Leu Gln Gln  Arg Pro Ser 
    1760                 1765                 1770             


Val Phe  Gln Gly Thr Asn Gly  Thr Ser Val Ile Thr  Pro Leu Asp 
    1775                 1780                 1785             


Pro Thr  Ala Gln Leu Arg Ile  Met Pro Leu Pro Ala  Gly Gly Pro 
    1790                 1795                 1800             


Ser Ile  Ser Gln Gly Leu Pro  Ala Ser Arg Tyr Asn  Thr Ala Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ala Ala Leu Val  Asp Ala Ala Ala Ser  Ala Pro Gln 
    1820                 1825                 1830             


Met Asp  Val Ser Lys Thr Lys  Glu Ser Lys His Glu  Ala Ala Arg 
    1835                 1840                 1845             


Leu Glu  Glu Asn Leu Arg Ser  Arg Ser Ala Ala Val  Ser Glu Gln 
    1850                 1855                 1860             


Gln Gln  Leu Glu Gln Lys Thr  Leu Glu Val Glu Lys  Arg Ser Val 
    1865                 1870                 1875             


Gln Cys  Leu Tyr Thr Ser Ser  Ala Phe Pro Ser Gly  Lys Pro Gln 
    1880                 1885                 1890             


Pro His  Ser Ser Val Val Tyr  Ser Glu Ala Gly Lys  Asp Lys Gly 
    1895                 1900                 1905             


Pro Pro  Pro Lys Ser Arg Tyr  Glu Glu Glu Leu Arg  Thr Arg Gly 
    1910                 1915                 1920             


Lys Thr  Thr Ile Thr Ala Ala  Asn Phe Ile Asp Val  Ile Ile Thr 
    1925                 1930                 1935             


Arg Gln  Ile Ala Ser Asp Lys  Asp Ala Arg Glu Arg  Gly Ser Gln 
    1940                 1945                 1950             


Ser Ser  Asp Ser Ser Ser Ser  Leu Ser Ser His Arg  Tyr Glu Thr 
    1955                 1960                 1965             


Pro Ser  Asp Ala Ile Glu Val  Ile Ser Pro Ala Ser  Ser Pro Ala 
    1970                 1975                 1980             


Pro Pro  Gln Glu Lys Leu Gln  Thr Tyr Gln Pro Glu  Val Val Lys 
    1985                 1990                 1995             


Ala Asn  Gln Ala Glu Asn Asp  Pro Thr Arg Gln Tyr  Glu Gly Pro 
    2000                 2005                 2010             


Leu His  His Tyr Arg Pro Gln  Gln Glu Ser Pro Ser  Pro Gln Gln 
    2015                 2020                 2025             


Gln Leu  Pro Pro Ser Ser Gln  Ala Glu Gly Met Gly  Gln Val Pro 
    2030                 2035                 2040             


Arg Thr  His Arg Leu Ile Thr  Leu Ala Asp His Ile  Cys Gln Ile 
    2045                 2050                 2055             


Ile Thr  Gln Asp Phe Ala Arg  Asn Gln Val Ser Ser  Gln Thr Pro 
    2060                 2065                 2070             


Gln Gln  Pro Pro Thr Ser Thr  Phe Gln Asn Ser Pro  Ser Ala Leu 
    2075                 2080                 2085             


Val Ser  Thr Pro Val Arg Thr  Lys Thr Ser Asn Arg  Tyr Ser Pro 
    2090                 2095                 2100             


Glu Ser  Gln Ala Gln Ser Val  His His Gln Arg Pro  Gly Ser Arg 
    2105                 2110                 2115             


Val Ser  Pro Glu Asn Leu Val  Asp Lys Ser Arg Gly  Ser Arg Pro 
    2120                 2125                 2130             


Gly Lys  Ser Pro Glu Arg Ser  His Val Ser Ser Glu  Pro Tyr Glu 
    2135                 2140                 2145             


Pro Ile  Ser Pro Pro Gln Val  Pro Val Val His Glu  Lys Gln Asp 
    2150                 2155                 2160             


Ser Leu  Leu Leu Leu Ser Gln  Arg Gly Ala Glu Pro  Ala Glu Gln 
    2165                 2170                 2175             


Arg Asn  Asp Ala Arg Ser Pro  Gly Ser Ile Ser Tyr  Leu Pro Ser 
    2180                 2185                 2190             


Phe Phe  Thr Lys Leu Glu Asn  Thr Ser Pro Met Val  Lys Ser Lys 
    2195                 2200                 2205             


Lys Gln  Glu Ile Phe Arg Lys  Leu Asn Ser Ser Gly  Gly Gly Asp 
    2210                 2215                 2220             


Ser Asp  Met Ala Ala Ala Gln  Pro Gly Thr Glu Ile  Phe Asn Leu 
    2225                 2230                 2235             


Pro Ala  Val Thr Thr Ser Gly  Ser Val Ser Ser Arg  Gly His Ser 
    2240                 2245                 2250             


Phe Ala  Asp Pro Ala Ser Asn  Leu Gly Leu Glu Asp  Ile Ile Arg 
    2255                 2260                 2265             


Lys Ala  Leu Met Gly Ser Phe  Asp Asp Lys Val Glu  Asp His Gly 
    2270                 2275                 2280             


Val Val  Met Ser Gln Pro Met  Gly Val Val Pro Gly  Thr Ala Asn 
    2285                 2290                 2295             


Thr Ser  Val Val Thr Ser Gly  Glu Thr Arg Arg Glu  Glu Gly Asp 
    2300                 2305                 2310             


Pro Ser  Pro His Ser Gly Gly  Val Cys Lys Pro Lys  Leu Ile Ser 
    2315                 2320                 2325             


Lys Ser  Asn Ser Arg Lys Ser  Lys Ser Pro Ile Pro  Gly Gln Gly 
    2330                 2335                 2340             


Tyr Leu  Gly Thr Glu Arg Pro  Ser Ser Val Ser Ser  Val His Ser 
    2345                 2350                 2355             


Glu Gly  Asp Tyr His Arg Gln  Thr Pro Gly Trp Ala  Trp Glu Asp 
    2360                 2365                 2370             


Arg Pro  Ser Ser Thr Gly Ser  Thr Gln Phe Pro Tyr  Asn Pro Leu 
    2375                 2380                 2385             


Thr Met  Arg Met Leu Ser Ser  Thr Pro Pro Thr Pro  Ile Ala Cys 
    2390                 2395                 2400             


Ala Pro  Ser Ala Val Asn Gln  Ala Ala Pro His Gln  Gln Asn Arg 
    2405                 2410                 2415             


Ile Trp  Glu Arg Glu Pro Ala  Pro Leu Leu Ser Ala  Gln Tyr Glu 
    2420                 2425                 2430             


Thr Leu  Ser Asp Ser Asp Asp  
    2435                 2440 


<210> 4997
<211> 770
<212> PRT
<213> Homo sapiens

<400> 4997
Met Leu Gln Gln Val Asn Gly His Asn Pro Gly Ser Asp Gly Gln Ala 
1               5                   10                  15      


Arg Glu Tyr Leu Arg Glu Asp Leu Gln Glu Phe Leu Gly Gly Glu Val 
            20                  25                  30          


Leu Leu Tyr Lys Leu Asp Asp Leu Thr Arg Val Asn Pro Val Thr Leu 
        35                  40                  45              


Glu Thr Val Leu Arg Cys Leu Gln Ala Arg Tyr Met Ala Asp Thr Phe 
    50                  55                  60                  


Tyr Thr Asn Ala Gly Cys Thr Leu Val Ala Leu Asn Pro Phe Lys Pro 
65                  70                  75                  80  


Val Pro Gln Leu Tyr Ser Pro Glu Leu Met Arg Glu Tyr His Ala Ala 
                85                  90                  95      


Pro Gln Pro Gln Lys Leu Lys Pro His Val Phe Thr Val Gly Glu Gln 
            100                 105                 110         


Thr Tyr Arg Asn Val Lys Ser Leu Ile Glu Pro Val Asn Gln Ser Ile 
        115                 120                 125             


Val Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Trp Thr Ser Arg Cys 
    130                 135                 140                 


Leu Met Lys Phe Tyr Ala Val Val Ala Thr Ser Pro Ala Ser Trp Glu 
145                 150                 155                 160 


Ser His Lys Ile Ala Glu Arg Ile Glu Gln Arg Ile Leu Asn Ser Asn 
                165                 170                 175     


Pro Val Met Glu Ala Phe Gly Asn Ala Cys Thr Leu Arg Asn Asn Asn 
            180                 185                 190         


Ser Ser Arg Phe Gly Lys Phe Ile Gln Leu Gln Leu Asn Arg Ala Gln 
        195                 200                 205             


Gln Met Thr Gly Ala Ala Val Gln Thr Tyr Leu Leu Glu Lys Thr Arg 
    210                 215                 220                 


Val Ala Cys Gln Ala Ser Ser Glu Arg Asn Phe His Ile Phe Tyr Gln 
225                 230                 235                 240 


Ile Cys Lys Gly Ala Ser Glu Asp Glu Arg Leu Gln Trp His Leu Pro 
                245                 250                 255     


Glu Gly Ala Ala Phe Ser Trp Leu Pro Asn Pro Glu Arg Ser Leu Glu 
            260                 265                 270         


Glu Asp Cys Phe Glu Val Thr Arg Glu Ala Met Leu His Leu Gly Ile 
        275                 280                 285             


Asp Thr Pro Thr Gln Asn Asn Ile Phe Lys Val Leu Ala Gly Leu Leu 
    290                 295                 300                 


His Leu Gly Asn Ile Gln Phe Ala Ala Ser Glu Asp Glu Ala Gln Pro 
305                 310                 315                 320 


Cys Gln Pro Met Asp Asp Ala Lys Tyr Ser Val Arg Thr Ala Ala Ser 
                325                 330                 335     


Leu Leu Gly Leu Pro Glu Asp Val Leu Leu Glu Met Val Gln Ile Arg 
            340                 345                 350         


Thr Ile Arg Ala Gly Arg Gln Gln Gln Val Phe Arg Lys Pro Cys Ala 
        355                 360                 365             


Arg Ala Glu Cys Asp Thr Arg Arg Asp Cys Leu Ala Lys Leu Ile Tyr 
    370                 375                 380                 


Ala Arg Leu Phe Asp Trp Leu Val Ser Val Ile Asn Ser Ser Ile Cys 
385                 390                 395                 400 


Ala Asp Thr Asp Ser Trp Thr Thr Phe Ile Gly Leu Leu Asp Val Tyr 
                405                 410                 415     


Gly Phe Glu Ser Phe Pro Asp Asn Ser Leu Glu Gln Leu Cys Ile Asn 
            420                 425                 430         


Tyr Ala Asn Glu Lys Leu Gln Leu Glu Ala Cys Gly Leu Val Glu Thr 
        435                 440                 445             


Ile His Ile Ser Ala Ala Gly Phe Pro Ile Arg Val Ser His Arg Asn 
    450                 455                 460                 


Phe Val Glu Arg Tyr Lys Leu Leu Arg Arg Leu His Pro Cys Thr Ser 
465                 470                 475                 480 


Ser Gly Pro Asp Ser Pro Tyr Pro Ala Lys Gly Leu Pro Glu Trp Cys 
                485                 490                 495     


Pro His Ser Glu Glu Ala Thr Leu Glu Pro Leu Ile Gln Asp Ile Leu 
            500                 505                 510         


His Thr Leu Pro Val Leu Thr Gln Ala Ala Ala Ile Thr Gly Asp Ser 
        515                 520                 525             


Ala Glu Ala Met Pro Ala Pro Met His Cys Gly Arg Thr Lys Val Phe 
    530                 535                 540                 


Met Thr Asp Ser Met Leu Glu Leu Leu Glu Cys Gly Arg Ala Arg Val 
545                 550                 555                 560 


Leu Glu Gln Cys Ala Arg Cys Ile Gln Gly Gly Trp Arg Arg His Arg 
                565                 570                 575     


His Arg Glu Gln Glu Arg Gln Trp Arg Ala Val Met Leu Ile Gln Ala 
            580                 585                 590         


Ala Ile Arg Ser Trp Leu Thr Arg Lys His Ile Gln Arg Leu His Ala 
        595                 600                 605             


Ala Ala Thr Val Ile Lys Arg Ala Trp Gln Lys Trp Arg Ile Arg Met 
    610                 615                 620                 


Ala Cys Leu Ala Ala Lys Glu Leu Asp Gly Val Glu Glu Lys His Phe 
625                 630                 635                 640 


Ser Gln Ala Pro Cys Ser Leu Ser Thr Ser Pro Leu Gln Thr Arg Leu 
                645                 650                 655     


Leu Glu Ala Ile Ile Arg Leu Trp Pro Leu Gly Leu Val Leu Ala Asn 
            660                 665                 670         


Thr Ala Met Gly Val Gly Ser Phe Gln Arg Lys Leu Val Val Trp Ala 
        675                 680                 685             


Cys Leu Gln Leu Pro Arg Gly Ser Pro Ser Ser Tyr Thr Val Gln Thr 
    690                 695                 700                 


Ala Gln Asp Gln Ala Gly Val Thr Ser Ile Arg Ala Leu Pro Gln Gly 
705                 710                 715                 720 


Ser Ile Lys Phe His Cys Arg Lys Ser Pro Leu Arg Tyr Ala Asp Ile 
                725                 730                 735     


Cys Pro Glu Pro Ser Pro Tyr Ser Ile Thr Gly Phe Asn Gln Ile Leu 
            740                 745                 750         


Leu Glu Arg His Arg Leu Ile His Val Thr Ser Ser Ala Phe Thr Gly 
        755                 760                 765             


Leu Gly 
    770 


<210> 4998
<211> 931
<212> PRT
<213> Homo sapiens

<400> 4998
Met Ala Glu Val Glu Ala Val Gln Leu Lys Glu Glu Gly Asn Arg His 
1               5                   10                  15      


Phe Gln Leu Gln Asp Tyr Lys Ala Ala Thr Asn Ser Tyr Ser Gln Ala 
            20                  25                  30          


Leu Lys Leu Thr Lys Asp Lys Ala Leu Leu Ala Thr Leu Tyr Arg Asn 
        35                  40                  45              


Arg Ala Ala Cys Gly Leu Lys Thr Glu Ser Tyr Val Gln Ala Ala Ser 
    50                  55                  60                  


Asp Ala Ser Arg Ala Ile Asp Ile Asn Ser Ser Asp Ile Lys Ala Leu 
65                  70                  75                  80  


Tyr Arg Arg Cys Gln Ala Leu Glu His Leu Gly Lys Leu Asp Gln Ala 
                85                  90                  95      


Phe Lys Asp Val Gln Arg Cys Ala Thr Leu Glu Pro Arg Asn Gln Asn 
            100                 105                 110         


Phe Gln Glu Met Leu Arg Arg Leu Asn Thr Ser Ile Gln Glu Lys Leu 
        115                 120                 125             


Arg Val Gln Phe Ser Thr Asp Ser Arg Val Gln Lys Met Phe Glu Ile 
    130                 135                 140                 


Leu Leu Asp Glu Asn Ser Glu Ala Asp Lys Arg Glu Lys Ala Ala Asn 
145                 150                 155                 160 


Asn Leu Ile Val Leu Gly Arg Glu Glu Ala Gly Ala Glu Lys Ile Phe 
                165                 170                 175     


Gln Asn Asn Gly Val Ala Leu Leu Leu Gln Leu Leu Asp Thr Lys Lys 
            180                 185                 190         


Pro Glu Leu Val Leu Ala Ala Val Arg Thr Leu Ser Gly Met Cys Ser 
        195                 200                 205             


Gly His Gln Ala Arg Ala Thr Val Ile Leu His Ala Val Arg Ile Asp 
    210                 215                 220                 


Arg Ile Cys Ser Leu Met Ala Val Glu Asn Glu Glu Met Ser Leu Ala 
225                 230                 235                 240 


Val Cys Asn Leu Leu Gln Ala Ile Ile Asp Ser Leu Ser Gly Glu Asp 
                245                 250                 255     


Lys Arg Glu His Arg Gly Lys Glu Glu Ala Leu Val Leu Asp Thr Lys 
            260                 265                 270         


Lys Asp Leu Lys Gln Ile Thr Ser His Leu Leu Asp Met Leu Val Ser 
        275                 280                 285             


Lys Lys Val Ser Gly Gln Gly Arg Asp Gln Ala Leu Asn Leu Leu Asn 
    290                 295                 300                 


Lys Asn Val Pro Arg Lys Asp Leu Ala Ile His Asp Asn Ser Arg Thr 
305                 310                 315                 320 


Ile Tyr Val Val Asp Asn Gly Leu Arg Lys Ile Leu Lys Val Val Gly 
                325                 330                 335     


Gln Val Pro Asp Leu Pro Ser Cys Leu Pro Leu Thr Asp Asn Thr Arg 
            340                 345                 350         


Met Leu Ala Ser Ile Leu Ile Asn Lys Leu Tyr Asp Asp Leu Arg Cys 
        355                 360                 365             


Asp Pro Glu Arg Asp His Phe Arg Lys Ile Cys Glu Glu Tyr Ile Thr 
    370                 375                 380                 


Gly Lys Phe Asp Pro Gln Asp Met Asp Lys Asn Leu Asn Ala Ile Gln 
385                 390                 395                 400 


Thr Val Ser Gly Ile Leu Gln Gly Pro Phe Asp Leu Gly Asn Gln Leu 
                405                 410                 415     


Leu Gly Leu Lys Gly Val Met Glu Met Met Val Ala Leu Cys Gly Ser 
            420                 425                 430         


Glu Arg Glu Thr Asp Gln Leu Val Ala Val Glu Ala Leu Ile His Ala 
        435                 440                 445             


Ser Thr Lys Leu Ser Arg Ala Thr Phe Ile Ile Thr Asn Gly Val Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ile Tyr Lys Thr Thr Lys Asn Glu Lys Ile Lys Ile 
465                 470                 475                 480 


Arg Thr Leu Val Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr Asp 
                485                 490                 495     


Tyr Gly Leu Arg Gln Phe Ala Glu Gly Ser Thr Glu Lys Leu Ala Lys 
            500                 505                 510         


Gln Cys Arg Lys Trp Leu Cys Asn Met Ser Ile Asp Thr Arg Thr Arg 
        515                 520                 525             


Arg Trp Ala Val Glu Gly Leu Ala Tyr Leu Thr Leu Asp Ala Asp Val 
    530                 535                 540                 


Lys Asp Asp Phe Val Gln Asp Val Pro Ala Leu Gln Ala Met Phe Glu 
545                 550                 555                 560 


Leu Ala Lys Ala Gly Thr Ser Asp Lys Thr Ile Leu Tyr Ser Val Ala 
                565                 570                 575     


Thr Thr Leu Val Asn Cys Thr Asn Ser Tyr Asp Val Lys Glu Val Ile 
            580                 585                 590         


Pro Glu Leu Val Gln Leu Ala Lys Phe Ser Lys Gln His Val Pro Glu 
        595                 600                 605             


Glu His Pro Lys Asp Lys Lys Asp Phe Ile Asp Met Arg Val Lys Arg 
    610                 615                 620                 


Leu Leu Lys Ala Gly Val Ile Ser Ala Leu Ala Cys Met Val Lys Ala 
625                 630                 635                 640 


Asp Ser Ala Ile Leu Thr Asp Gln Thr Lys Glu Leu Leu Ala Arg Val 
                645                 650                 655     


Phe Leu Ala Leu Cys Asp Asn Pro Lys Asp Arg Gly Thr Ile Val Ala 
            660                 665                 670         


Gln Gly Gly Gly Lys Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp 
        675                 680                 685             


Val Gly Lys Val Lys Ala Ala His Ala Leu Ala Lys Ile Ala Ala Val 
    690                 695                 700                 


Ser Asn Pro Asp Ile Ala Phe Pro Gly Glu Arg Val Tyr Glu Val Val 
705                 710                 715                 720 


Arg Pro Leu Val Arg Leu Leu Asp Thr Gln Arg Asp Gly Leu Gln Asn 
                725                 730                 735     


Tyr Glu Ala Leu Leu Gly Leu Thr Asn Leu Ser Gly Arg Ser Asp Lys 
            740                 745                 750         


Leu Arg Gln Lys Ile Phe Lys Glu Arg Ala Leu Pro Asp Ile Glu Asn 
        755                 760                 765             


Tyr Met Phe Glu Asn His Asp Gln Leu Arg Gln Ala Ala Thr Glu Cys 
    770                 775                 780                 


Met Cys Asn Met Val Leu His Lys Glu Val Gln Glu Arg Phe Leu Ala 
785                 790                 795                 800 


Asp Gly Asn Asp Arg Leu Lys Leu Val Val Leu Leu Cys Gly Glu Asp 
                805                 810                 815     


Asp Asp Lys Val Gln Asn Ala Ala Ala Gly Ala Leu Ala Met Leu Thr 
            820                 825                 830         


Ala Ala His Lys Lys Leu Cys Leu Lys Met Thr Gln Val Thr Thr Gln 
        835                 840                 845             


Trp Leu Glu Ile Leu Gln Arg Leu Cys Leu His Asp Gln Leu Ser Val 
    850                 855                 860                 


Gln His Arg Gly Leu Val Ile Ala Tyr Asn Leu Leu Ala Ala Asp Ala 
865                 870                 875                 880 


Glu Leu Ala Lys Lys Leu Val Glu Ser Glu Leu Leu Glu Ile Leu Thr 
                885                 890                 895     


Val Val Gly Lys Gln Glu Pro Asp Glu Lys Lys Ala Glu Val Val Gln 
            900                 905                 910         


Thr Ala Arg Glu Cys Leu Ile Lys Cys Met Asp Tyr Gly Phe Ile Lys 
        915                 920                 925             


Pro Val Ser 
    930     


<210> 4999
<211> 673
<212> PRT
<213> Homo sapiens

<400> 4999
Met Ala Ser Gln Phe Cys Leu Pro Glu Ser Pro Cys Leu Ser Pro Leu 
1               5                   10                  15      


Lys Pro Leu Lys Pro His Phe Gly Asp Ile Gln Glu Gly Ile Tyr Val 
            20                  25                  30          


Ala Ile Gln Arg Ser Asp Lys Arg Ile His Leu Ala Val Val Thr Glu 
        35                  40                  45              


Ile Asn Arg Glu Asn Tyr Trp Val Thr Val Glu Trp Val Glu Lys Ala 
    50                  55                  60                  


Val Lys Lys Gly Lys Lys Ile Asp Leu Glu Thr Ile Leu Leu Leu Asn 
65                  70                  75                  80  


Pro Ala Leu Asp Ser Ala Glu His Pro Met Pro Pro Pro Pro Leu Ser 
                85                  90                  95      


Pro Leu Ala Leu Ala Pro Ser Ser Ala Ile Arg Asp Gln Arg Thr Ala 
            100                 105                 110         


Thr Lys Trp Val Ala Met Ile Pro Gln Lys Asn Gln Thr Ala Ser Gly 
        115                 120                 125             


Asp Ser Leu Asp Val Arg Val Pro Ser Lys Pro Cys Leu Met Lys Gln 
    130                 135                 140                 


Lys Lys Ser Pro Cys Leu Trp Glu Ile Gln Lys Leu Gln Glu Gln Arg 
145                 150                 155                 160 


Glu Lys Arg Arg Arg Leu Gln Gln Glu Ile Arg Ala Arg Arg Ala Leu 
                165                 170                 175     


Asp Val Asn Thr Arg Asn Pro Asn Tyr Glu Ile Met His Met Ile Glu 
            180                 185                 190         


Glu Tyr Arg Arg His Leu Asp Ser Ser Lys Ile Ser Val Leu Glu Pro 
        195                 200                 205             


Pro Gln Glu His Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn 
    210                 215                 220                 


Gln Arg Glu Thr Thr Leu Lys Asp Leu Asp Ile Ile Thr Val Pro Ser 
225                 230                 235                 240 


Asp Asn Val Val Met Val His Glu Ser Lys Gln Lys Val Asp Leu Thr 
                245                 250                 255     


Arg Tyr Leu Gln Asn Gln Thr Phe Cys Phe Asp His Ala Phe Asp Asp 
            260                 265                 270         


Lys Ala Ser Asn Glu Leu Val Tyr Gln Phe Thr Ala Gln Pro Leu Val 
        275                 280                 285             


Glu Ser Ile Phe Arg Lys Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln 
    290                 295                 300                 


Thr Gly Ser Gly Lys Thr Tyr Thr Met Gly Gly Asp Phe Ser Gly Thr 
305                 310                 315                 320 


Ala Gln Asp Cys Ser Lys Gly Ile Tyr Ala Leu Val Ala Gln Asp Val 
                325                 330                 335     


Phe Leu Leu Leu Arg Asn Ser Thr Tyr Glu Lys Leu Asp Leu Lys Val 
            340                 345                 350         


Tyr Gly Thr Phe Phe Glu Ile Tyr Gly Gly Lys Val Tyr Asp Leu Leu 
        355                 360                 365             


Asn Trp Lys Lys Lys Leu Gln Val Leu Glu Asp Gly Asn Gln Gln Ile 
    370                 375                 380                 


Gln Val Val Gly Leu Gln Glu Lys Glu Val Cys Cys Val Glu Glu Val 
385                 390                 395                 400 


Leu Asn Leu Val Glu Ile Gly Asn Ser Cys Arg Thr Ser Arg Gln Thr 
                405                 410                 415     


Pro Val Asn Ala His Ser Ser Arg Ser His Ala Val Phe Gln Ile Ile 
            420                 425                 430         


Leu Lys Ser Gly Arg Ile Met His Gly Lys Phe Ser Leu Val Asp Leu 
        435                 440                 445             


Ala Gly Asn Glu Arg Gly Ala Asp Thr Thr Lys Ala Ser Arg Lys Arg 
    450                 455                 460                 


Gln Leu Glu Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu 
465                 470                 475                 480 


Cys Ile Leu Ala Leu Gly Gln Asn Lys Pro His Thr Pro Phe Arg Ala 
                485                 490                 495     


Ser Lys Leu Thr Leu Val Leu Arg Asp Ser Phe Ile Gly Gln Asn Ser 
            500                 505                 510         


Ser Thr Cys Met Ile Ala Thr Ile Ser Pro Gly Met Thr Ser Cys Glu 
        515                 520                 525             


Asn Thr Leu Asn Thr Leu Arg Tyr Ala Asn Arg Val Lys Lys Leu Asn 
    530                 535                 540                 


Val Asp Val Arg Pro Tyr His Arg Gly His Tyr Pro Ile Gly His Glu 
545                 550                 555                 560 


Ala Pro Arg Met Leu Lys Ser His Ile Gly Asn Ser Glu Met Ser Leu 
                565                 570                 575     


Gln Arg Asp Glu Phe Ile Lys Ile Pro Tyr Val Gln Ser Glu Glu Gln 
            580                 585                 590         


Lys Glu Ile Glu Glu Val Glu Thr Leu Pro Thr Leu Leu Gly Lys Asp 
        595                 600                 605             


Thr Thr Ile Ser Gly Lys Gly Ser Ser Gln Trp Leu Glu Asn Ile Gln 
    610                 615                 620                 


Glu Arg Ala Gly Gly Val His His Asp Ile Asp Phe Cys Ile Ala Arg 
625                 630                 635                 640 


Ser Leu Ser Ile Leu Glu Gln Lys Ile Asp Ala Leu Thr Glu Ile Gln 
                645                 650                 655     


Lys Lys Leu Lys Leu Leu Leu Ala Asp Leu His Val Lys Ser Lys Val 
            660                 665                 670         


Glu 
    


<210> 5000
<211> 411
<212> PRT
<213> Homo sapiens

<400> 5000
Met Ala Thr Thr Ala Thr Met Ala Thr Ser Gly Ser Ala Arg Lys Arg 
1               5                   10                  15      


Leu Leu Lys Glu Glu Asp Met Thr Lys Val Glu Phe Glu Thr Ser Glu 
            20                  25                  30          


Glu Val Asp Val Thr Pro Thr Phe Asp Thr Met Gly Leu Arg Glu Asp 
        35                  40                  45              


Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile 
    50                  55                  60                  


Gln Gln Arg Ala Ile Lys Gln Ile Ile Lys Gly Arg Asp Val Ile Ala 
65                  70                  75                  80  


Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Thr Phe Ser Ile Ser Val 
                85                  90                  95      


Leu Gln Cys Leu Asp Ile Gln Val Arg Glu Thr Gln Ala Leu Ile Leu 
            100                 105                 110         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Gln Lys Gly Leu Leu Ala 
        115                 120                 125             


Leu Gly Asp Tyr Met Asn Val Gln Cys His Ala Cys Ile Gly Gly Thr 
    130                 135                 140                 


Asn Val Gly Glu Asp Ile Arg Lys Leu Asp Tyr Gly Gln His Val Val 
145                 150                 155                 160 


Ala Gly Thr Pro Gly Arg Val Phe Asp Met Ile Arg Arg Arg Ser Leu 
                165                 170                 175     


Arg Thr Arg Ala Ile Lys Met Leu Val Leu Asp Glu Ala Asp Glu Met 
            180                 185                 190         


Leu Asn Lys Gly Phe Lys Glu Gln Ile Tyr Asp Val Tyr Arg Tyr Leu 
        195                 200                 205             


Pro Pro Ala Thr Gln Val Val Leu Ile Ser Ala Thr Leu Pro His Glu 
    210                 215                 220                 


Ile Leu Glu Met Thr Asn Lys Phe Met Thr Asp Pro Ile Arg Ile Leu 
225                 230                 235                 240 


Val Lys Arg Asp Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Phe Val 
                245                 250                 255     


Ala Val Glu Arg Glu Glu Trp Lys Phe Asp Thr Leu Cys Asp Leu Tyr 
            260                 265                 270         


Asp Thr Leu Thr Ile Thr Gln Ala Val Ile Phe Cys Asn Thr Lys Arg 
        275                 280                 285             


Lys Val Asp Trp Leu Thr Glu Lys Met Arg Glu Ala Asn Phe Thr Val 
    290                 295                 300                 


Ser Ser Met His Gly Asp Met Pro Gln Lys Glu Arg Glu Ser Ile Met 
305                 310                 315                 320 


Lys Glu Phe Arg Ser Gly Ala Ser Arg Val Leu Ile Ser Thr Asp Val 
                325                 330                 335     


Trp Ala Arg Gly Leu Asp Val Pro Gln Val Ser Leu Ile Ile Asn Tyr 
            340                 345                 350         


Asp Leu Pro Asn Asn Arg Glu Leu Tyr Ile His Arg Ile Gly Arg Ser 
        355                 360                 365             


Gly Arg Tyr Gly Arg Lys Gly Val Ala Ile Asn Phe Val Lys Asn Asp 
    370                 375                 380                 


Asp Ile Arg Ile Leu Arg Asp Ile Glu Gln Tyr Tyr Ser Thr Gln Ile 
385                 390                 395                 400 


Asp Glu Met Pro Met Asn Val Ala Asp Leu Ile 
                405                 410     


<210> 5001
<211> 560
<212> PRT
<213> Homo sapiens

<400> 5001
Met Glu Leu Pro Ala Val Gly Glu His Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Glu Lys Lys Arg Ile Arg Lys Gly Arg Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Arg Gly Trp Ser Pro Lys Tyr Asn Thr Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Arg Glu Arg Gln Glu 
    50                  55                  60                  


Gln Leu Met Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Pro Leu Val 
65                  70                  75                  80  


Val Gln Val Pro Thr Phe Ala Arg Arg Ser Asn Val Leu Thr Gly Leu 
                85                  90                  95      


Gln Asp Ser Ser Thr Asp Asn Arg Ala Lys Leu Asp Leu Gly Ala Gln 
            100                 105                 110         


Gly Lys Gly Gln Gly His Gln Tyr Glu Leu Asn Ser Lys Lys His His 
        115                 120                 125             


Gln Tyr Gln Pro His Ser Lys Glu Arg Ala Gly Lys Pro Pro Pro Pro 
    130                 135                 140                 


Gly Lys Ser Gly Lys Tyr Tyr Tyr Gln Leu Asn Ser Lys Lys His His 
145                 150                 155                 160 


Pro Tyr Gln Pro Asp Pro Lys Met Tyr Asp Leu Gln Tyr Gln Gly Gly 
                165                 170                 175     


His Lys Glu Ala Pro Ser Pro Thr Cys Pro Asp Leu Gly Ala Lys Ser 
            180                 185                 190         


His Pro Pro Asp Lys Trp Ala Gln Gly Ala Gly Ala Lys Gly Tyr Leu 
        195                 200                 205             


Gly Ala Val Lys Pro Leu Ala Gly Ala Ala Gly Ala Pro Gly Lys Gly 
    210                 215                 220                 


Ser Glu Lys Gly Pro Pro Asn Gly Met Met Pro Ala Pro Lys Glu Ala 
225                 230                 235                 240 


Val Thr Gly Asn Gly Ile Gly Gly Lys Met Lys Ile Val Lys Asn Lys 
                245                 250                 255     


Asn Lys Asn Gly Arg Ile Val Ile Val Met Ser Lys Tyr Met Glu Asn 
            260                 265                 270         


Gly Met Gln Ala Val Lys Ile Lys Ser Gly Glu Val Ala Glu Gly Glu 
        275                 280                 285             


Ala Arg Ser Pro Ser His Lys Lys Arg Ala Ala Asp Glu Arg His Pro 
    290                 295                 300                 


Pro Ala Asp Arg Thr Phe Lys Lys Ala Ala Gly Ala Glu Glu Lys Lys 
305                 310                 315                 320 


Val Glu Ala Pro Pro Lys Arg Arg Glu Glu Glu Val Ser Gly Val Ser 
                325                 330                 335     


Asp Pro Gln Pro Gln Asp Ala Gly Ser Arg Lys Leu Ser Pro Thr Lys 
            340                 345                 350         


Glu Ala Phe Gly Glu Gln Pro Leu Gln Leu Thr Thr Lys Pro Asp Leu 
        355                 360                 365             


Leu Ala Trp Asp Pro Ala Arg Asn Thr His Pro Pro Ser His His Pro 
    370                 375                 380                 


His Pro His Pro His His His His His His His His His His His His 
385                 390                 395                 400 


Ala Val Gly Leu Asn Leu Ser His Val Arg Lys Arg Cys Leu Ser Glu 
                405                 410                 415     


Thr His Gly Glu Arg Glu Pro Cys Lys Lys Arg Leu Thr Ala Arg Ser 
            420                 425                 430         


Ile Ser Thr Pro Thr Cys Leu Gly Gly Ser Pro Ala Ala Glu Arg Pro 
        435                 440                 445             


Ala Asp Leu Pro Pro Ala Ala Ala Leu Pro Gln Pro Glu Val Ile Leu 
    450                 455                 460                 


Leu Asp Ser Asp Leu Asp Glu Pro Ile Asp Leu Arg Cys Val Lys Thr 
465                 470                 475                 480 


Arg Ser Glu Ala Gly Glu Pro Pro Ser Ser Leu Gln Val Lys Pro Glu 
                485                 490                 495     


Thr Pro Ala Ser Ala Ala Val Ala Val Ala Ala Ala Ala Ala Pro Thr 
            500                 505                 510         


Thr Thr Ala Glu Lys Pro Pro Ala Glu Ala Gln Asp Glu Pro Ala Glu 
        515                 520                 525             


Ser Leu Ser Glu Phe Lys Pro Phe Phe Gly Asn Ile Ile Ile Thr Asp 
    530                 535                 540                 


Val Thr Ala Asn Cys Leu Thr Val Thr Phe Lys Glu Tyr Val Thr Val 
545                 550                 555                 560 


<210> 5002
<211> 405
<212> PRT
<213> Homo sapiens

<400> 5002
Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe 
1               5                   10                  15      


Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro 
            20                  25                  30          


Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser 
        35                  40                  45              


Asp Ser Ala His Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser 
    50                  55                  60                  


Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln 
65                  70                  75                  80  


Lys Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val Ser Cys Tyr Phe 
                85                  90                  95      


Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr Asp Tyr Thr Leu 
            100                 105                 110         


Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe Pro Ile Cys Gln 
        115                 120                 125             


Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr Thr Ile Glu Ser 
    130                 135                 140                 


Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln Glu Ile Asn Phe 
145                 150                 155                 160 


Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu Leu Phe Ser Lys 
                165                 170                 175     


Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val Asn Ala Val Tyr 
            180                 185                 190         


Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu Asn Thr Val Asp 
        195                 200                 205             


Ala Pro Phe Cys Leu Asn Ala Asn Glu Asn Lys Ser Val Lys Met Met 
    210                 215                 220                 


Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu Glu Val Lys Ala 
225                 230                 235                 240 


Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu Ser Met Phe Val 
                245                 250                 255     


Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly Leu Glu Glu Leu 
            260                 265                 270         


Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp Ser Ser Ser Glu 
        275                 280                 285             


Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro Arg Phe Thr Leu 
    290                 295                 300                 


Glu Asp Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp Met Gly Ile Thr 
305                 310                 315                 320 


Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly Ile Ser Pro Ser 
                325                 330                 335     


Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr Phe Val Glu Val 
            340                 345                 350         


Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly Ala Val Val Ser 
        355                 360                 365             


Glu Arg Ser Leu Arg Ser Trp Val Glu Phe Asn Ala Asn His Pro Phe 
    370                 375                 380                 


Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile Leu Phe Tyr Gly 
385                 390                 395                 400 


Arg Val Cys Ser Pro 
                405 


<210> 5003
<211> 1178
<212> PRT
<213> Homo sapiens

<400> 5003
Met Leu Arg Met Lys Leu Pro Leu Lys Pro Thr His Pro Ala Glu Pro 
1               5                   10                  15      


Pro Pro Glu Ala Glu Glu Pro Glu Ala Asp Ala Arg Pro Gly Ala Lys 
            20                  25                  30          


Ala Pro Ser Arg Arg Arg Arg Asp Cys Arg Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Gly Pro Ser Arg Gly Pro Leu Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Arg Gly Leu Gly Pro Pro Val Ala Gly Gly Ala Ala Ala Gly Ala Gly 
65                  70                  75                  80  


Met Pro Gly Gly Gly Gly Gly Pro Ser Ala Ala Leu Arg Glu Gln Glu 
                85                  90                  95      


Arg Val Tyr Glu Trp Phe Gly Leu Val Leu Gly Ser Ala Gln Arg Leu 
            100                 105                 110         


Glu Phe Met Cys Gly Leu Leu Asp Leu Cys Asn Pro Leu Glu Leu Arg 
        115                 120                 125             


Phe Leu Gly Ser Cys Leu Glu Asp Leu Ala Arg Lys Asp Tyr His Tyr 
    130                 135                 140                 


Leu Arg Asp Ser Glu Ala Lys Ala Asn Gly Leu Ser Asp Pro Gly Pro 
145                 150                 155                 160 


Leu Ala Asp Phe Arg Glu Pro Ala Val Arg Ser Arg Leu Ile Val Tyr 
                165                 170                 175     


Leu Ala Leu Leu Gly Ser Glu Asn Arg Glu Ala Ala Gly Arg Leu His 
            180                 185                 190         


Arg Leu Leu Pro Gln Val Asp Ser Val Leu Lys Ser Leu Arg Ala Ala 
        195                 200                 205             


Arg Gly Glu Gly Ser Arg Gly Gly Ala Glu Asp Glu Arg Gly Glu Asp 
    210                 215                 220                 


Gly Asp Gly Glu Gln Asp Ala Glu Lys Asp Gly Ser Gly Pro Glu Gly 
225                 230                 235                 240 


Gly Ile Val Glu Pro Arg Val Gly Gly Gly Leu Gly Ser Arg Ala Gln 
                245                 250                 255     


Glu Glu Leu Leu Leu Leu Phe Thr Met Ala Ser Leu His Pro Ala Phe 
            260                 265                 270         


Ser Phe His Gln Arg Val Thr Leu Arg Glu His Leu Glu Arg Leu Arg 
        275                 280                 285             


Ala Ala Leu Arg Gly Gly Pro Glu Asp Ala Glu Val Glu Val Glu Pro 
    290                 295                 300                 


Cys Lys Phe Ala Gly Pro Arg Ala Gln Asn Asn Ser Ala His Gly Asp 
305                 310                 315                 320 


Tyr Met Gln Asn Asn Glu Ser Ser Leu Ile Glu Gln Ala Pro Ile Pro 
                325                 330                 335     


Gln Asp Gly Leu Thr Val Ala Pro His Arg Ala Gln Arg Glu Ala Val 
            340                 345                 350         


His Ile Glu Lys Ile Met Leu Lys Gly Val Gln Arg Lys Arg Ala Asp 
        355                 360                 365             


Lys Tyr Trp Glu Tyr Thr Phe Lys Val Asn Trp Ser Asp Leu Ser Val 
    370                 375                 380                 


Thr Thr Val Thr Lys Thr His Gln Glu Leu Gln Glu Phe Leu Leu Lys 
385                 390                 395                 400 


Leu Pro Lys Glu Leu Ser Ser Glu Thr Phe Asp Lys Thr Ile Leu Arg 
                405                 410                 415     


Ala Leu Asn Gln Gly Ser Leu Lys Arg Glu Glu Arg Arg His Pro Asp 
            420                 425                 430         


Leu Glu Pro Ile Leu Arg Gln Leu Phe Ser Ser Ser Ser Gln Ala Phe 
        435                 440                 445             


Leu Gln Ser Gln Lys Val His Ser Phe Phe Gln Ser Ile Ser Ser Asp 
    450                 455                 460                 


Ser Leu His Ser Ile Asn Asn Leu Gln Ser Ser Leu Lys Thr Ser Lys 
465                 470                 475                 480 


Ile Leu Glu His Leu Lys Glu Asp Ser Ser Glu Ala Ser Ser Gln Glu 
                485                 490                 495     


Glu Asp Val Leu Gln His Ala Ile Ile His Lys Lys His Thr Gly Lys 
            500                 505                 510         


Ser Pro Ile Val Asn Asn Ile Gly Thr Ser Cys Ser Pro Leu Asp Gly 
        515                 520                 525             


Leu Thr Met Gln Tyr Ser Glu Gln Asn Gly Ile Val Asp Trp Arg Lys 
    530                 535                 540                 


Gln Ser Cys Thr Thr Ile Gln His Pro Glu His Cys Val Thr Ser Ala 
545                 550                 555                 560 


Asp Gln His Ser Ala Glu Lys Arg Ser Leu Ser Ser Ile Asn Lys Lys 
                565                 570                 575     


Lys Gly Lys Pro Gln Thr Glu Lys Glu Lys Ile Lys Lys Thr Asp Asn 
            580                 585                 590         


Arg Leu Asn Ser Arg Ile Asn Gly Ile Arg Leu Ser Thr Pro Gln His 
        595                 600                 605             


Ala His Gly Gly Thr Val Lys Asp Val Asn Leu Asp Ile Gly Ser Gly 
    610                 615                 620                 


His Asp Thr Cys Gly Glu Thr Ser Ser Glu Ser Tyr Ser Ser Pro Ser 
625                 630                 635                 640 


Ser Pro Arg His Asp Gly Arg Glu Ser Phe Glu Ser Glu Glu Glu Lys 
                645                 650                 655     


Asp Arg Asp Thr Asp Ser Asn Ser Glu Asp Ser Gly Asn Pro Ser Thr 
            660                 665                 670         


Thr Arg Phe Thr Gly Tyr Gly Ser Val Asn Gln Thr Val Thr Val Lys 
        675                 680                 685             


Pro Pro Val Gln Ile Ala Ser Leu Gly Asn Glu Asn Gly Asn Leu Leu 
    690                 695                 700                 


Glu Asp Pro Leu Asn Ser Pro Lys Tyr Gln His Ile Ser Phe Met Pro 
705                 710                 715                 720 


Thr Leu His Cys Val Met His Asn Gly Ala Gln Lys Ser Glu Val Val 
                725                 730                 735     


Val Pro Ala Pro Lys Pro Ala Asp Gly Lys Thr Ile Gly Met Leu Val 
            740                 745                 750         


Pro Ser Pro Val Ala Ile Ser Ala Ile Arg Glu Ser Ala Asn Ser Thr 
        755                 760                 765             


Pro Val Gly Ile Leu Gly Pro Thr Ala Cys Thr Gly Glu Ser Glu Lys 
    770                 775                 780                 


His Leu Glu Leu Leu Ala Ser Pro Leu Pro Ile Pro Ser Thr Phe Leu 
785                 790                 795                 800 


Pro His Ser Ser Thr Pro Ala Leu His Leu Thr Val Gln Arg Leu Lys 
                805                 810                 815     


Leu Pro Pro Pro Gln Gly Ser Ser Glu Ser Cys Thr Val Asn Ile Pro 
            820                 825                 830         


Gln Gln Pro Pro Gly Ser Leu Ser Ile Ala Ser Pro Asn Thr Ala Phe 
        835                 840                 845             


Ile Pro Ile His Asn Pro Gly Ser Phe Pro Gly Ser Pro Val Ala Thr 
    850                 855                 860                 


Thr Asp Pro Ile Thr Lys Ser Ala Ser Gln Val Val Gly Leu Asn Gln 
865                 870                 875                 880 


Met Val Pro Gln Ile Glu Gly Asn Thr Gly Thr Val Pro Gln Pro Thr 
                885                 890                 895     


Asn Val Lys Val Val Leu Pro Ala Ala Gly Leu Ser Ala Ala Gln Pro 
            900                 905                 910         


Pro Ala Ser Tyr Pro Leu Pro Gly Ser Pro Leu Ala Ala Gly Val Leu 
        915                 920                 925             


Pro Ser Gln Asn Ser Ser Val Leu Ser Thr Ala Ala Thr Ser Pro Gln 
    930                 935                 940                 


Pro Ala Ser Ala Gly Ile Ser Gln Ala Gln Ala Thr Val Pro Pro Ala 
945                 950                 955                 960 


Val Pro Thr His Thr Pro Gly Pro Ala Pro Ser Pro Ser Pro Ala Leu 
                965                 970                 975     


Thr His Ser Thr Ala Gln Ser Asp Ser Thr Ser Tyr Ile Ser Ala Val 
            980                 985                 990         


Gly Asn Thr Asn Ala Asn Gly Thr  Val Val Pro Pro Gln  Gln Met Gly 
        995                 1000                 1005             


Ser Gly  Pro Cys Gly Ser Cys  Gly Arg Arg Cys Ser  Cys Gly Thr 
    1010                 1015                 1020             


Asn Gly  Asn Leu Gln Leu Asn  Ser Tyr Tyr Tyr Pro  Asn Pro Met 
    1025                 1030                 1035             


Pro Gly  Pro Met Tyr Arg Val  Pro Ser Phe Phe Thr  Leu Pro Ser 
    1040                 1045                 1050             


Ile Cys  Asn Gly Ser Tyr Leu  Asn Gln Ala His Gln  Ser Asn Gly 
    1055                 1060                 1065             


Asn Gln  Leu Pro Phe Phe Leu  Pro Gln Thr Pro Tyr  Ala Asn Gly 
    1070                 1075                 1080             


Leu Val  His Asp Pro Val Met  Gly Ser Gln Ala Asn  Tyr Gly Met 
    1085                 1090                 1095             


Gln Gln  Met Ala Gly Phe Gly  Arg Phe Tyr Pro Val  Tyr Pro Ala 
    1100                 1105                 1110             


Pro Asn  Val Val Ala Asn Thr  Ser Gly Ser Gly Pro  Lys Lys Asn 
    1115                 1120                 1125             


Gly Asn  Val Ser Cys Tyr Asn  Cys Gly Val Ser Gly  His Tyr Ala 
    1130                 1135                 1140             


Gln Asp  Cys Lys Gln Ser Ser  Met Glu Ala Asn Gln  Gln Gly Thr 
    1145                 1150                 1155             


Tyr Arg  Leu Arg Tyr Ala Pro  Pro Leu Pro Pro Ser  Asn Asp Thr 
    1160                 1165                 1170             


Leu Asp  Ser Ala Asp 
    1175             


<210> 5004
<211> 136
<212> PRT
<213> Homo sapiens

<400> 5004
Met Pro Gly Lys Lys Ala Arg Lys Asn Ala Gln Pro Ser Pro Ala Arg 
1               5                   10                  15      


Ala Pro Ala Gly Pro Ala Gly Thr Ala Gly Thr Ala Arg Asp Gln Ala 
            20                  25                  30          


Gly Phe Ala Ile Gly Met Gln Leu Arg Phe Thr Arg Gly Lys Lys Leu 
        35                  40                  45              


Leu Ser Ser Ser Leu Ser Ser Ser Pro Leu Ala Leu Pro Arg Gly His 
    50                  55                  60                  


Glu Glu Gln Val Gln Val Ala Gly Ser Arg Val Cys Tyr Ser Thr Gln 
65                  70                  75                  80  


Glu Ile Trp Arg Gln Thr Glu Leu Pro Ala Glu Thr Ser Glu Ser Asp 
                85                  90                  95      


Ile Gln Thr Leu Leu Leu Arg Asn Leu Thr Ala Ser Lys Thr Cys Met 
            100                 105                 110         


Arg Gly Leu Leu Gln Lys Ser Phe Leu Arg Arg Cys Thr Phe His Gln 
        115                 120                 125             


Phe Glu Glu Arg Leu His Cys Asn 
    130                 135     


<210> 5005
<211> 292
<212> PRT
<213> Homo sapiens

<400> 5005
Met Lys Ala Thr Val Leu Met Arg Gln Pro Gly Arg Val Gln Glu Ile 
1               5                   10                  15      


Val Gly Ala Leu Arg Lys Gly Gly Gly Asp Arg Leu Gln Val Ile Ser 
            20                  25                  30          


Asp Phe Asp Met Thr Leu Ser Arg Phe Ala Tyr Asn Gly Lys Arg Cys 
        35                  40                  45              


Pro Ser Ser Tyr Asn Ile Leu Asp Asn Ser Lys Ile Ile Ser Glu Glu 
    50                  55                  60                  


Cys Arg Lys Glu Leu Thr Ala Leu Leu His His Tyr Tyr Pro Ile Glu 
65                  70                  75                  80  


Ile Asp Pro His Arg Thr Val Lys Glu Lys Leu Pro His Met Val Glu 
                85                  90                  95      


Trp Trp Thr Lys Ala His Asn Leu Leu Cys Gln Gln Lys Ile Gln Lys 
            100                 105                 110         


Phe Gln Ile Ala Gln Val Val Arg Glu Ser Asn Ala Met Leu Arg Glu 
        115                 120                 125             


Gly Tyr Lys Thr Phe Phe Asn Thr Leu Tyr His Asn Asn Ile Pro Leu 
    130                 135                 140                 


Phe Ile Phe Ser Ala Gly Ile Gly Asp Ile Leu Glu Glu Ile Ile Arg 
145                 150                 155                 160 


Gln Met Lys Val Phe His Pro Asn Ile His Ile Val Ser Asn Tyr Met 
                165                 170                 175     


Asp Phe Asn Glu Asp Gly Phe Leu Gln Gly Phe Lys Gly Gln Leu Ile 
            180                 185                 190         


His Thr Tyr Asn Lys Asn Ser Ser Ala Cys Glu Asn Ser Gly Tyr Phe 
        195                 200                 205             


Gln Gln Leu Glu Gly Lys Thr Asn Val Ile Leu Leu Gly Asp Ser Ile 
    210                 215                 220                 


Gly Asp Leu Thr Met Ala Asp Gly Val Pro Gly Val Gln Asn Ile Leu 
225                 230                 235                 240 


Lys Ile Gly Phe Leu Asn Asp Lys Val Glu Glu Arg Arg Glu Arg Tyr 
                245                 250                 255     


Met Asp Ser Tyr Asp Ile Val Leu Glu Lys Asp Glu Thr Leu Asp Val 
            260                 265                 270         


Val Asn Gly Leu Leu Gln His Ile Leu Cys Gln Gly Val Gln Leu Glu 
        275                 280                 285             


Met Gln Gly Pro 
    290         


<210> 5006
<211> 669
<212> PRT
<213> Homo sapiens

<400> 5006
Met Asp Leu Arg Thr Ala Val Tyr Asn Ala Ala Arg Asp Gly Lys Leu 
1               5                   10                  15      


Gln Leu Leu Gln Lys Leu Leu Ser Gly Arg Ser Arg Glu Glu Leu Asp 
            20                  25                  30          


Glu Leu Thr Gly Glu Val Ala Gly Gly Gly Thr Pro Leu Leu Ile Ala 
        35                  40                  45              


Ala Arg Tyr Gly His Leu Asp Val Val Glu Tyr Leu Val Asp Arg Cys 
    50                  55                  60                  


Gly Ala Ser Val Glu Ala Gly Gly Ser Val His Phe Asp Gly Glu Thr 
65                  70                  75                  80  


Ile Glu Gly Ala Pro Pro Leu Trp Ala Ala Ser Ala Ala Gly His Leu 
                85                  90                  95      


Asp Val Val Arg Ser Leu Leu Arg Arg Gly Ala Ser Val Asn Arg Thr 
            100                 105                 110         


Thr Arg Thr Asn Ser Thr Pro Leu Arg Ala Ala Cys Phe Asp Gly His 
        115                 120                 125             


Leu Glu Val Val Arg Tyr Leu Val Gly Glu His Gln Ala Asp Leu Glu 
    130                 135                 140                 


Val Ala Asn Arg His Gly His Thr Cys Leu Met Ile Ser Cys Tyr Lys 
145                 150                 155                 160 


Gly His Arg Glu Ile Ala Arg Tyr Leu Leu Glu Gln Gly Ala Gln Val 
                165                 170                 175     


Asn Arg Arg Ser Ala Lys Gly Asn Thr Ala Leu His Asp Cys Ala Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Ile Leu Gln Leu Leu Leu Gly Cys Lys Ala Arg 
        195                 200                 205             


Met Glu Arg Asp Gly Tyr Gly Met Thr Pro Leu Leu Ala Ala Ser Val 
    210                 215                 220                 


Thr Gly His Thr Asn Ile Val Glu Tyr Leu Ile Gln Glu Gln Pro Gly 
225                 230                 235                 240 


Gln Glu Gln Val Ala Gly Gly Glu Ala Gln Pro Gly Leu Pro Gln Glu 
                245                 250                 255     


Asp Pro Ser Thr Ser Gln Gly Cys Ala Gln Pro Gln Gly Ala Pro Cys 
            260                 265                 270         


Cys Ser Ser Ser Pro Glu Glu Pro Leu Asn Gly Glu Ser Tyr Glu Ser 
        275                 280                 285             


Cys Cys Pro Thr Ser Arg Glu Ala Ala Val Glu Ala Leu Glu Leu Leu 
    290                 295                 300                 


Gly Ala Thr Tyr Val Asp Lys Lys Arg Asp Leu Leu Gly Ala Leu Lys 
305                 310                 315                 320 


His Trp Arg Arg Ala Met Glu Leu Arg His Gln Gly Gly Glu Tyr Leu 
                325                 330                 335     


Pro Lys Pro Glu Pro Pro Gln Leu Val Leu Ala Tyr Asp Tyr Ser Arg 
            340                 345                 350         


Glu Val Asn Thr Thr Glu Glu Leu Glu Ala Leu Ile Thr Asp Pro Asp 
        355                 360                 365             


Glu Met Arg Met Gln Ala Leu Leu Ile Arg Glu Arg Ile Leu Gly Pro 
    370                 375                 380                 


Ser His Pro Asp Thr Ser Tyr Tyr Ile Arg Tyr Arg Gly Ala Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Gly Asn Phe Glu Arg Cys Ile Arg Leu Trp Lys Tyr Ala 
                405                 410                 415     


Leu Asp Met Gln Gln Ser Asn Leu Glu Pro Leu Ser Pro Met Thr Ala 
            420                 425                 430         


Ser Ser Phe Leu Ser Phe Ala Glu Leu Phe Ser Tyr Val Leu Gln Asp 
        435                 440                 445             


Arg Ala Ala Lys Gly Ser Leu Gly Thr Gln Ile Gly Phe Ala Asp Leu 
    450                 455                 460                 


Met Gly Val Leu Thr Lys Gly Val Arg Glu Val Glu Arg Ala Leu Gln 
465                 470                 475                 480 


Leu Pro Arg Glu Pro Gly Asp Ser Ala Gln Phe Thr Lys Ala Leu Ala 
                485                 490                 495     


Ile Ile Leu His Leu Leu Tyr Leu Leu Glu Lys Val Glu Cys Thr Pro 
            500                 505                 510         


Ser Gln Glu His Leu Lys His Gln Thr Val Tyr Arg Leu Leu Lys Cys 
        515                 520                 525             


Ala Pro Arg Gly Lys Asn Gly Phe Thr Pro Leu His Met Ala Val Asp 
    530                 535                 540                 


Lys Asp Thr Thr Asn Val Gly Arg Tyr Pro Val Gly Arg Phe Pro Ser 
545                 550                 555                 560 


Leu His Val Val Lys Val Leu Leu Asp Cys Gly Ala Asp Pro Asp Ser 
                565                 570                 575     


Arg Asp Phe Asp Asn Asn Thr Pro Leu His Ile Ala Ala Gln Asn Asn 
            580                 585                 590         


Cys Pro Ala Ile Met Asn Ala Leu Ile Glu Ala Gly Ala His Met Asp 
        595                 600                 605             


Ala Thr Asn Ala Phe Lys Lys Thr Ala Tyr Glu Leu Leu Asp Glu Lys 
    610                 615                 620                 


Leu Leu Ala Arg Gly Thr Met Gln Pro Phe Asn Tyr Val Thr Leu Gln 
625                 630                 635                 640 


Cys Leu Ala Ala Arg Ala Leu Asp Lys Asn Lys Ile Pro Tyr Lys Gly 
                645                 650                 655     


Phe Ile Pro Glu Asp Leu Glu Ala Phe Ile Glu Leu His 
            660                 665                 


<210> 5007
<211> 239
<212> PRT
<213> Homo sapiens

<400> 5007
Met Ala Ala Thr Leu Leu Ala Ala Arg Gly Ala Gly Pro Ala Pro Ala 
1               5                   10                  15      


Trp Gly Pro Glu Ala Phe Thr Pro Asp Trp Glu Ser Arg Glu Val Ser 
            20                  25                  30          


Thr Gly Thr Thr Ile Met Ala Val Gln Phe Asp Gly Gly Val Val Leu 
        35                  40                  45              


Gly Ala Asp Ser Arg Thr Thr Thr Gly Ser Tyr Ile Ala Asn Arg Val 
    50                  55                  60                  


Thr Asp Lys Leu Thr Pro Ile His Asp Arg Ile Phe Cys Cys Arg Ser 
65                  70                  75                  80  


Gly Ser Ala Ala Asp Thr Gln Ala Val Ala Asp Ala Val Thr Tyr Gln 
                85                  90                  95      


Leu Gly Phe His Ser Ile Glu Leu Asn Glu Pro Pro Leu Val His Thr 
            100                 105                 110         


Ala Ala Ser Leu Phe Lys Glu Met Cys Tyr Arg Tyr Arg Glu Asp Leu 
        115                 120                 125             


Met Ala Gly Ile Ile Ile Ala Gly Trp Asp Pro Gln Glu Gly Gly Gln 
    130                 135                 140                 


Val Tyr Ser Val Pro Met Gly Gly Met Met Val Arg Gln Ser Phe Ala 
145                 150                 155                 160 


Ile Gly Gly Ser Gly Ser Ser Tyr Ile Tyr Gly Tyr Val Asp Ala Thr 
                165                 170                 175     


Tyr Arg Glu Gly Met Thr Lys Glu Glu Cys Leu Gln Phe Thr Ala Asn 
            180                 185                 190         


Ala Leu Ala Leu Ala Met Glu Arg Asp Gly Ser Ser Gly Gly Val Ile 
        195                 200                 205             


Arg Leu Ala Ala Ile Ala Glu Ser Gly Val Glu Arg Gln Val Leu Leu 
    210                 215                 220                 


Gly Asp Gln Ile Pro Lys Phe Ala Val Ala Thr Leu Pro Pro Ala 
225                 230                 235                 


<210> 5008
<211> 460
<212> PRT
<213> Homo sapiens

<400> 5008
Met Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe 
1               5                   10                  15      


Ser Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val 
            20                  25                  30          


Val Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu 
        35                  40                  45              


Asp Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu 
    50                  55                  60                  


Cys Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln 
65                  70                  75                  80  


Pro Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala 
                85                  90                  95      


Ser Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe 
            100                 105                 110         


His Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr 
        115                 120                 125             


Ile Lys Tyr Pro Lys Ala Cys Leu Gln Gly Ile Thr Phe Thr Arg Asp 
    130                 135                 140                 


Gly Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val 
145                 150                 155                 160 


Ser Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg His Phe Asp Thr 
                165                 170                 175     


Asp Thr Gln Asp Leu Thr Gly Ile Glu Trp Ala Pro Asn Gly Cys Val 
            180                 185                 190         


Leu Ala Val Trp Asp Thr Cys Leu Glu Tyr Lys Ile Leu Leu Tyr Ser 
        195                 200                 205             


Leu Asp Gly Arg Leu Leu Ser Thr Tyr Ser Ala Tyr Glu Trp Ser Leu 
    210                 215                 220                 


Gly Ile Lys Ser Val Ala Trp Ser Pro Ser Ser Gln Phe Leu Ala Val 
225                 230                 235                 240 


Gly Ser Tyr Asp Gly Lys Val Arg Ile Leu Asn His Val Thr Trp Lys 
                245                 250                 255     


Met Ile Thr Glu Phe Gly His Pro Ala Ala Ile Asn Asp Pro Lys Ile 
            260                 265                 270         


Val Val Tyr Lys Glu Ala Glu Lys Ser Pro Gln Leu Gly Leu Gly Cys 
        275                 280                 285             


Leu Ser Phe Pro Pro Pro Arg Ala Gly Ala Gly Pro Leu Pro Ser Ser 
    290                 295                 300                 


Glu Ser Lys Tyr Glu Ile Ala Ser Val Pro Val Ser Leu Gln Thr Leu 
305                 310                 315                 320 


Lys Pro Val Thr Asp Arg Ala Asn Pro Lys Ile Gly Ile Gly Met Leu 
                325                 330                 335     


Ala Phe Ser Pro Asp Ser Tyr Phe Leu Ala Thr Arg Asn Asp Asn Ile 
            340                 345                 350         


Pro Asn Ala Val Trp Val Trp Asp Ile Gln Lys Leu Arg Leu Phe Ala 
        355                 360                 365             


Val Leu Glu Gln Leu Ser Pro Val Arg Ala Phe Gln Trp Asp Pro Gln 
    370                 375                 380                 


Gln Pro Arg Leu Ala Ile Cys Thr Gly Gly Ser Arg Leu Tyr Leu Trp 
385                 390                 395                 400 


Ser Pro Ala Gly Cys Met Ser Val Gln Val Pro Gly Glu Gly Asp Phe 
                405                 410                 415     


Ala Val Leu Ser Leu Cys Trp His Leu Ser Gly Asp Ser Met Ala Leu 
            420                 425                 430         


Leu Ser Lys Asp His Phe Cys Leu Cys Phe Leu Glu Thr Glu Ala Val 
        435                 440                 445             


Val Gly Thr Ala Cys Arg Gln Leu Gly Gly His Thr 
    450                 455                 460 


<210> 5009
<211> 93
<212> PRT
<213> Homo sapiens

<400> 5009
Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala 
65                  70                  75                  80  


Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys Leu Ala 
                85                  90              


<210> 5010
<211> 639
<212> PRT
<213> Homo sapiens

<400> 5010
Met Asn Leu Glu Lys Leu Ser Lys Pro Glu Leu Leu Thr Leu Phe Ser 
1               5                   10                  15      


Ile Leu Glu Gly Glu Leu Glu Ala Arg Asp Leu Val Ile Glu Ala Leu 
            20                  25                  30          


Lys Ala Gln His Arg Asp Thr Phe Ile Glu Glu Arg Tyr Gly Lys Tyr 
        35                  40                  45              


Asn Ile Ser Asp Pro Leu Met Ala Leu Gln Arg Asp Phe Glu Thr Leu 
    50                  55                  60                  


Lys Glu Lys Asn Asp Gly Glu Lys Gln Pro Val Cys Thr Asn Pro Leu 
65                  70                  75                  80  


Ser Ile Leu Lys Val Val Met Lys Gln Cys Lys Asn Met Gln Glu Arg 
                85                  90                  95      


Met Leu Ser Gln Leu Ala Ala Ala Glu Ser Arg His Arg Lys Val Ile 
            100                 105                 110         


Leu Asp Leu Glu Glu Glu Arg Gln Arg His Ala Gln Asp Thr Ala Glu 
        115                 120                 125             


Gly Asp Asp Val Thr Tyr Met Leu Glu Lys Glu Arg Glu Arg Leu Thr 
    130                 135                 140                 


Gln Gln Leu Glu Phe Glu Lys Ser Gln Val Lys Lys Phe Glu Lys Glu 
145                 150                 155                 160 


Gln Lys Lys Leu Ser Ser Gln Leu Glu Glu Glu Arg Ser Arg His Lys 
                165                 170                 175     


Gln Leu Ser Ser Met Leu Val Leu Glu Cys Lys Lys Ala Thr Asn Lys 
            180                 185                 190         


Ala Ala Glu Glu Gly Gln Lys Ala Gly Glu Leu Ser Leu Lys Leu Glu 
        195                 200                 205             


Lys Glu Lys Ser Arg Val Ser Lys Leu Glu Glu Glu Leu Ala Ala Glu 
    210                 215                 220                 


Arg Lys Arg Gly Leu Gln Thr Glu Ala Gln Val Glu Lys Gln Leu Ser 
225                 230                 235                 240 


Glu Phe Asp Ile Glu Arg Glu Gln Leu Arg Ala Lys Leu Asn Arg Glu 
                245                 250                 255     


Glu Asn Arg Thr Lys Thr Leu Lys Glu Glu Met Glu Ser Leu Lys Lys 
            260                 265                 270         


Ile Val Lys Asp Leu Glu Ala Ser His Gln His Ser Ser Pro Asn Glu 
        275                 280                 285             


Gln Leu Lys Lys Pro Val Thr Val Ser Lys Gly Thr Ala Thr Glu Pro 
    290                 295                 300                 


Leu Met Leu Met Ser Val Phe Cys Gln Thr Glu Ser Phe Pro Ala Glu 
305                 310                 315                 320 


Arg Thr His Gly Ser Asn Ile Ala Lys Met Thr Asn Thr Gly Leu Pro 
                325                 330                 335     


Gly Pro Ala Thr Pro Ala Tyr Ser Tyr Ala Lys Thr Asn Gly His Cys 
            340                 345                 350         


Asp Pro Glu Ile Gln Thr Thr Arg Glu Leu Thr Ala Gly Asn Asn Val 
        355                 360                 365             


Glu Asn Gln Val Pro Pro Arg Glu Lys Ser Val Ala Leu Ala Gln Glu 
    370                 375                 380                 


Lys Pro Val Glu Asn Gly Gly Cys Pro Val Gly Ile Glu Thr Pro Val 
385                 390                 395                 400 


Pro Met Pro Ser Pro Leu Ser Ser Ser Gly Ser Ser Leu Ser Pro Ser 
                405                 410                 415     


Ser Thr Ala Ser Ser Ser Leu Thr Ser Ser Pro Cys Ser Ser Pro Val 
            420                 425                 430         


Leu Thr Lys Arg Leu Leu Gly Ser Ser Ala Ser Ser Pro Gly Tyr Gln 
        435                 440                 445             


Ser Ser Tyr Gln Val Gly Ile Asn Gln Arg Phe His Ala Ala Arg His 
    450                 455                 460                 


Lys Phe Gln Ser Gln Ala Asp Gln Asp Gln Gln Ala Ser Gly Leu Gln 
465                 470                 475                 480 


Ser Pro Pro Ser Arg Asp Leu Ser Pro Thr Leu Ile Asp Asn Ser Ala 
                485                 490                 495     


Ala Lys Gln Leu Ala Arg Asn Thr Val Thr Gln Val Leu Ser Arg Phe 
            500                 505                 510         


Thr Ser Gln Gln Gly Pro Ile Lys Pro Val Ser Pro Asn Ser Ser Pro 
        515                 520                 525             


Phe Gly Thr Asp Tyr Arg Asn Leu Ala Asn Thr Ala Asn Pro Arg Gly 
    530                 535                 540                 


Asp Thr Ser His Ser Pro Thr Pro Gly Lys Val Ser Ser Pro Leu Ser 
545                 550                 555                 560 


Pro Leu Ser Pro Gly Ile Lys Ser Pro Thr Ile Pro Arg Ala Glu Arg 
                565                 570                 575     


Gly Asn Pro Pro Pro Ile Pro Pro Lys Lys Pro Gly Leu Thr Pro Ser 
            580                 585                 590         


Pro Ser Ala Thr Thr Pro Leu Thr Lys Thr His Ser Gln Ala Ala Ser 
        595                 600                 605             


Leu Thr Thr Ala Glu Asp Leu Ala Ser Ser Cys Ser Ser Asn Thr Val 
    610                 615                 620                 


Val Ala Asn Gly Lys Asp Val Glu Leu Leu Leu Pro Thr Ser Ser 
625                 630                 635                 


<210> 5011
<211> 828
<212> PRT
<213> Homo sapiens

<400> 5011
Met Arg Phe Leu Glu Ala Arg Ser Leu Ala Val Ala Met Gly Asp Thr 
1               5                   10                  15      


Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu Pro Thr Ser Gly 
            20                  25                  30          


Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val Ile Thr Glu Gly 
        35                  40                  45              


Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala Gln Lys Ala Cys 
    50                  55                  60                  


Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly Gly Val Ala Val 
65                  70                  75                  80  


Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly Asp Gly Val Asp 
                85                  90                  95      


Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln Ile Arg Glu Glu 
            100                 105                 110         


Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr Ala Lys Gly Ala 
        115                 120                 125             


Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser Trp Leu Leu Arg 
    130                 135                 140                 


Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala Ile Ser Tyr Leu 
145                 150                 155                 160 


Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile Gly Asn Arg Leu 
                165                 170                 175     


Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu Pro Gln Leu Leu 
            180                 185                 190         


Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp Ala Ile Lys Pro 
        195                 200                 205             


Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe Ser Leu Gln Cys 
    210                 215                 220                 


Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His Ile Ser Thr Gln 
225                 230                 235                 240 


Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile Leu Ser Asp Glu 
                245                 250                 255     


Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser Leu Ser Pro Ala 
            260                 265                 270         


Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His Gln Arg Ser Lys 
        275                 280                 285             


Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn Leu Lys Arg Thr 
    290                 295                 300                 


Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu Leu Ser Ser Ser 
305                 310                 315                 320 


Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val Arg Leu Ala Pro 
                325                 330                 335     


Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly Lys Arg Leu Ala 
            340                 345                 350         


Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu Ile Ser Glu Leu 
        355                 360                 365             


Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp Leu Pro Thr Ala 
    370                 375                 380                 


Gly Phe Asp His His Val Val Arg Val Pro His Thr Gln Ala Val Val 
385                 390                 395                 400 


Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr Val Glu Val Leu 
                405                 410                 415     


Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro Ala Arg Ile Pro Glu 
            420                 425                 430         


Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu Pro Glu Cys Gly 
        435                 440                 445             


Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr Val Pro Asn Tyr 
    450                 455                 460                 


Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile Gly Glu Leu Gln 
465                 470                 475                 480 


Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp Asn Ile Ser Gln 
                485                 490                 495     


Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys Glu Pro Val Phe 
            500                 505                 510         


Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu Gln Leu Ala His 
        515                 520                 525             


Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro Ser Ala Val Ala 
    530                 535                 540                 


Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile Arg Glu Gly Ser 
545                 550                 555                 560 


Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser Val Ile Val Lys 
                565                 570                 575     


Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe Gln Val Leu Lys 
            580                 585                 590         


Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro Leu Trp Ile Lys 
        595                 600                 605             


Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly Met Ile Glu Pro 
    610                 615                 620                 


Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys Gln Ser Gln Leu 
625                 630                 635                 640 


Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser Tyr Thr Thr Glu 
                645                 650                 655     


Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser Cys Ala Gly Tyr 
            660                 665                 670         


Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg His Asn Gly Asn 
        675                 680                 685             


Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile Asp Phe Gly Phe 
    690                 695                 700                 


Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu Thr Ser Ala Phe 
705                 710                 715                 720 


Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly Leu Asp Gly Asp 
                725                 730                 735     


Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly Leu Ile Ala Ala 
            740                 745                 750         


Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu Ile Met Gln Gln 
        755                 760                 765             


Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr Ile Arg Asn Leu 
    770                 775                 780                 


Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln Leu Gln Leu Leu 
785                 790                 795                 800 


Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile Thr Thr Lys Leu 
                805                 810                 815     


Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
            820                 825             


<210> 5012
<211> 1410
<212> PRT
<213> Homo sapiens

<400> 5012
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr Ser Ser Pro Val Ala 
    130                 135                 140                 


Ser Gln Pro Ile Phe Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val 
145                 150                 155                 160 


Arg Pro Val Gln Asn Ala Met Asn Gln Val Gly Ile Val Leu Asn Val 
                165                 170                 175     


Gln Gln Gly Gln Thr Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly 
            180                 185                 190         


Thr Gln Phe Val Lys Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln 
        195                 200                 205             


Met Thr Pro Val Arg Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr 
    210                 215                 220                 


Asn Thr Phe Thr Thr Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr 
225                 230                 235                 240 


Val Pro Gln Ser Gln Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser 
                245                 250                 255     


Thr Thr Pro Thr Ala Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val 
            260                 265                 270         


Gln Ser Pro Gly Gln Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro 
        275                 280                 285             


Ser Phe Pro Ser Pro Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val 
    290                 295                 300                 


Lys Arg Pro Gly Val Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu 
305                 310                 315                 320 


Val Asn Thr Leu Asn Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro 
                325                 330                 335     


Val Val Val Ser Asn Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser 
            340                 345                 350         


Gly Pro Glu Ser Ser Met Lys Val Thr Ser Ser Ile Pro Val Phe Asp 
        355                 360                 365             


Leu Gln Asp Gly Gly Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln Phe 
    370                 375                 380                 


Arg Val Thr Glu Ala Leu Arg Gly His Met Cys Tyr Cys Cys Pro Glu 
385                 390                 395                 400 


Met Val Glu Tyr Gln Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro Ser 
                405                 410                 415     


Val Pro Ser Ala Ala Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro Val 
            420                 425                 430         


Ala Ser Thr Pro Ser Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro Thr 
        435                 440                 445             


Lys Val Pro Glu Pro Asn Glu Asn Val Gly Asp Ala Val Gln Thr Lys 
    450                 455                 460                 


Leu Ile Met Leu Val Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly Lys 
465                 470                 475                 480 


Val Ala Gln Leu Thr Asn Phe Pro Lys Val Ala Thr Ser Phe Arg Cys 
                485                 490                 495     


Pro His Cys Thr Lys Arg Leu Lys Asn Asn Ile Arg Phe Met Asn His 
            500                 505                 510         


Met Lys His His Val Glu Leu Asp Gln Gln Asn Gly Glu Val Asp Gly 
        515                 520                 525             


His Thr Ile Cys Gln His Cys Tyr Arg Gln Phe Ser Thr Pro Phe Gln 
    530                 535                 540                 


Leu Gln Cys His Leu Glu Asn Val His Ser Pro Tyr Glu Ser Thr Thr 
545                 550                 555                 560 


Lys Cys Lys Ile Cys Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe Leu 
                565                 570                 575     


Gln His Met Lys Asp Thr His Lys Pro Gly Glu Met Pro Tyr Val Cys 
            580                 585                 590         


Gln Val Cys Gln Tyr Arg Ser Ser Leu Tyr Ser Glu Val Asp Val His 
        595                 600                 605             


Phe Arg Met Ile His Glu Asp Thr Arg His Leu Leu Cys Pro Tyr Cys 
    610                 615                 620                 


Leu Lys Val Phe Lys Asn Gly Asn Ala Phe Gln Gln His Tyr Met Arg 
625                 630                 635                 640 


His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys Arg Leu Gln Phe 
                645                 650                 655     


Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln His His Lys Thr 
            660                 665                 670         


Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro Gly Thr Lys Val 
        675                 680                 685             


Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val Pro Val Ser Ser 
    690                 695                 700                 


Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala Pro Leu Thr Ser 
705                 710                 715                 720 


Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro Val Gln Arg Ser 
                725                 730                 735     


Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met Gly Arg Gln Thr 
            740                 745                 750         


Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro Asn His Phe Pro 
        755                 760                 765             


Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr Cys Cys Ser Arg 
    770                 775                 780                 


Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro Arg Lys Ser Pro 
785                 790                 795                 800 


Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly Ile Lys Leu Ala 
                805                 810                 815     


Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp Ala Met Ala Lys 
            820                 825                 830         


His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser Ile Leu Pro Arg 
        835                 840                 845             


Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln Thr Arg Asp Arg 
    850                 855                 860                 


Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro Pro Ser Phe Pro 
865                 870                 875                 880 


Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala Thr Pro Ala Glu 
                885                 890                 895     


Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu Pro Ser Pro Ala 
            900                 905                 910         


Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro Gln Ala Leu Ala 
        915                 920                 925             


Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu Asn Val Asp Asp 
    930                 935                 940                 


Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu Leu Ala Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln Leu Ser Val Lys 
                965                 970                 975     


Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn Thr Glu Gln Ala 
            980                 985                 990         


Ala Glu His Phe Arg Asn Pro Gln  Arg Arg Ile Arg Arg  Trp Leu Arg 
        995                 1000                 1005             


Arg Phe  Gln Ala Ser Gln Gly  Glu Asn Leu Glu Gly  Lys Tyr Leu 
    1010                 1015                 1020             


Ser Phe  Glu Ala Glu Glu Lys  Leu Ala Glu Trp Val  Leu Thr Gln 
    1025                 1030                 1035             


Arg Glu  Gln Gln Leu Pro Val  Asn Glu Glu Thr Leu  Phe Gln Lys 
    1040                 1045                 1050             


Ala Thr  Lys Ile Gly Arg Ser  Leu Glu Gly Gly Phe  Lys Ile Ser 
    1055                 1060                 1065             


Tyr Glu  Trp Ala Val Arg Phe  Met Leu Arg His His  Leu Thr Pro 
    1070                 1075                 1080             


His Ala  Arg Arg Ala Val Ala  His Thr Leu Pro Lys  Asp Val Ala 
    1085                 1090                 1095             


Glu Asn  Ala Gly Leu Phe Ile  Asp Phe Val Gln Arg  Gln Ile His 
    1100                 1105                 1110             


Asn Gln  Asp Leu Pro Leu Ser  Met Ile Val Ala Ile  Asp Glu Ile 
    1115                 1120                 1125             


Ser Leu  Phe Leu Asp Thr Glu  Val Leu Ser Ser Asp  Asp Arg Lys 
    1130                 1135                 1140             


Glu Asn  Ala Leu Gln Thr Val  Gly Thr Gly Glu Pro  Trp Cys Asp 
    1145                 1150                 1155             


Val Val  Leu Ala Ile Leu Ala  Asp Gly Thr Val Leu  Pro Thr Leu 
    1160                 1165                 1170             


Val Phe  Tyr Arg Gly Gln Met  Asp Gln Pro Ala Asn  Met Pro Asp 
    1175                 1180                 1185             


Ser Ile  Leu Leu Glu Ala Lys  Glu Ser Gly Tyr Ser  Asp Asp Glu 
    1190                 1195                 1200             


Ile Met  Glu Leu Trp Ser Thr  Arg Val Trp Gln Lys  His Thr Ala 
    1205                 1210                 1215             


Cys Gln  Arg Ser Lys Gly Met  Leu Val Met Asp Cys  His Arg Thr 
    1220                 1225                 1230             


His Leu  Ser Glu Glu Val Leu  Ala Met Leu Ser Ala  Ser Ser Thr 
    1235                 1240                 1245             


Leu Pro  Ala Val Val Pro Ala  Gly Cys Ser Ser Lys  Ile Gln Pro 
    1250                 1255                 1260             


Leu Asp  Val Cys Ile Lys Arg  Thr Val Lys Asn Phe  Leu His Lys 
    1265                 1270                 1275             


Lys Trp  Lys Glu Gln Ala Arg  Glu Met Ala Asp Thr  Ala Cys Asp 
    1280                 1285                 1290             


Ser Asp  Val Leu Leu Gln Leu  Val Leu Val Trp Leu  Gly Glu Val 
    1295                 1300                 1305             


Leu Gly  Val Ile Gly Asp Cys  Pro Glu Leu Val Gln  Arg Ser Phe 
    1310                 1315                 1320             


Leu Val  Ala Ser Val Leu Pro  Gly Pro Asp Gly Asn  Ile Asn Ser 
    1325                 1330                 1335             


Pro Thr  Arg Asn Ala Asp Met  Gln Glu Glu Leu Ile  Ala Ser Leu 
    1340                 1345                 1350             


Glu Glu  Gln Leu Lys Leu Ser  Gly Glu His Ser Glu  Ser Ser Thr 
    1355                 1360                 1365             


Pro Arg  Pro Arg Ser Ser Pro  Glu Glu Thr Ile Glu  Pro Glu Ser 
    1370                 1375                 1380             


Leu His  Gln Leu Phe Glu Gly  Glu Ser Glu Thr Glu  Ser Phe Tyr 
    1385                 1390                 1395             


Gly Phe  Glu Glu Ala Asp Leu  Asp Leu Met Glu Ile  
    1400                 1405                 1410 


<210> 5013
<211> 495
<212> PRT
<213> Homo sapiens

<400> 5013
Met Pro Gln Leu Leu Gln Asn Ile Asn Gly Ile Ile Glu Ala Phe Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Thr Glu Gly Asn Cys Thr Ala Leu Thr Arg Gly Glu 
            20                  25                  30          


Leu Lys Arg Leu Leu Glu Gln Glu Phe Ala Asp Val Ile Val Lys Pro 
        35                  40                  45              


His Asp Pro Ala Thr Val Asp Glu Val Leu Arg Leu Leu Asp Glu Asp 
    50                  55                  60                  


His Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
65                  70                  75                  80  


Val Ala Gln Ala Cys Phe Lys Thr Leu Ser Glu Ser Ala Glu Gly Ala 
                85                  90                  95      


Cys Gly Ser Gln Glu Ser Gly Ser Leu His Ser Gly Ala Ser Gln Glu 
            100                 105                 110         


Leu Gly Glu Gly Gln Arg Ser Gly Thr Glu Val Gly Arg Ala Gly Lys 
        115                 120                 125             


Gly Gln His Tyr Glu Gly Ser Ser His Arg Gln Ser Gln Gln Gly Ser 
    130                 135                 140                 


Arg Gly Gln Asn Arg Pro Gly Val Gln Thr Gln Gly Gln Ala Thr Gly 
145                 150                 155                 160 


Ser Ala Trp Val Ser Ser Tyr Asp Arg Gln Ala Glu Ser Gln Ser Gln 
                165                 170                 175     


Glu Arg Ile Ser Pro Gln Ile Gln Leu Ser Gly Gln Thr Glu Gln Thr 
            180                 185                 190         


Gln Lys Ala Gly Glu Gly Lys Arg Asn Gln Thr Thr Glu Met Arg Pro 
        195                 200                 205             


Glu Arg Gln Pro Gln Thr Arg Glu Gln Asp Arg Ala His Gln Thr Gly 
    210                 215                 220                 


Glu Thr Val Thr Gly Ser Gly Thr Gln Thr Gln Ala Gly Ala Thr Gln 
225                 230                 235                 240 


Thr Val Glu Gln Asp Ser Ser His Gln Thr Gly Arg Thr Ser Lys Gln 
                245                 250                 255     


Thr Gln Glu Ala Thr Asn Asp Gln Asn Arg Gly Thr Glu Thr His Gly 
            260                 265                 270         


Gln Gly Arg Ser Gln Thr Ser Gln Ala Val Thr Gly Gly His Ala Gln 
        275                 280                 285             


Ile Gln Ala Gly Thr His Thr Gln Thr Pro Thr Gln Thr Val Glu Gln 
    290                 295                 300                 


Asp Ser Ser His Gln Thr Gly Ser Thr Ser Thr Gln Thr Gln Glu Ser 
305                 310                 315                 320 


Thr Asn Gly Gln Asn Arg Gly Thr Glu Ile His Gly Gln Gly Arg Ser 
                325                 330                 335     


Gln Thr Ser Gln Ala Val Thr Gly Gly His Thr Gln Ile Gln Ala Gly 
            340                 345                 350         


Ser His Thr Glu Thr Val Glu Gln Asp Arg Ser Gln Thr Val Ser His 
        355                 360                 365             


Gly Gly Ala Arg Glu Gln Gly Gln Thr Gln Thr Gln Pro Gly Ser Gly 
    370                 375                 380                 


Gln Arg Trp Met Gln Val Ser Asn Pro Glu Ala Gly Glu Thr Val Pro 
385                 390                 395                 400 


Gly Gly Gln Ala Gln Thr Gly Ala Ser Thr Glu Ser Gly Arg Gln Glu 
                405                 410                 415     


Trp Ser Ser Thr His Pro Arg Arg Cys Val Thr Glu Gly Gln Gly Asp 
            420                 425                 430         


Arg Gln Pro Thr Val Val Gly Glu Glu Trp Val Asp Asp His Ser Arg 
        435                 440                 445             


Glu Thr Val Ile Leu Arg Leu Asp Gln Gly Asn Leu His Thr Ser Val 
    450                 455                 460                 


Ser Ser Ala Gln Gly Gln Asp Ala Ala Gln Ser Glu Glu Lys Arg Gly 
465                 470                 475                 480 


Ile Thr Ala Arg Glu Leu Tyr Ser Tyr Leu Arg Ser Thr Lys Pro 
                485                 490                 495 


<210> 5014
<211> 410
<212> PRT
<213> Homo sapiens

<400> 5014
Met Asn Met Pro Ser Thr Pro Leu Ala Pro Thr Thr Gly Thr Ala Thr 
1               5                   10                  15      


Cys Ser Trp Ser Ala Ser Thr Cys Thr Thr Thr Arg Pro Ala Val Arg 
            20                  25                  30          


Pro Pro Ser Phe Pro His Arg Pro Pro Gly Asn Ala Ala Leu Pro Ser 
        35                  40                  45              


Leu Met Pro Ser Arg Pro Thr Gln Val Ala Gly Gln Cys Gly Ala Gly 
    50                  55                  60                  


Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu Met Glu 
65                  70                  75                  80  


Ser Val Met Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp Cys Leu 
                85                  90                  95      


Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly Ser Gly 
            100                 105                 110         


Met Gly Thr Leu Leu Leu Ser Lys Ile Arg Glu Glu Tyr Pro Asp Arg 
        115                 120                 125             


Ile Ile Asn Thr Phe Ser Ile Leu Pro Ser Pro Lys Val Ser Asp Thr 
    130                 135                 140                 


Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu Ile Glu 
145                 150                 155                 160 


Asn Ala Asp Glu Thr Phe Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile 
                165                 170                 175     


Cys Ser Lys Thr Leu Lys Leu Pro Thr Pro Thr Tyr Gly Asp Leu Asn 
            180                 185                 190         


His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu Arg Phe 
        195                 200                 205             


Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn Met Val 
    210                 215                 220                 


Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro Leu Thr 
225                 230                 235                 240 


Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Ala Glu Leu Thr 
                245                 250                 255     


Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp Pro Arg 
            260                 265                 270         


His Gly Arg Tyr Leu Thr Ala Ala Ala Ile Phe Arg Gly Arg Met Pro 
        275                 280                 285             


Met Arg Glu Val Asp Glu Gln Met Phe Asn Ile Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Tyr Phe Ala Asp Trp Leu Pro Asn Asn Val Lys Thr Ala Val Cys 
305                 310                 315                 320 


Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile Gly Asn 
                325                 330                 335     


Asn Thr Ala Ile Gln Glu Leu Phe Lys Arg Val Ser Glu Gln Phe Thr 
            340                 345                 350         


Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Gly 
        355                 360                 365             


Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn Asp Leu 
    370                 375                 380                 


Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu Glu Glu 
385                 390                 395                 400 


Asp Glu Glu Tyr Ala Glu Glu Glu Val Ala 
                405                 410 


<210> 5015
<211> 701
<212> PRT
<213> Homo sapiens

<400> 5015
Met Gly Ser Ala Ala Asp Val Arg Phe Ser Leu Gly Thr Thr Thr His 
1               5                   10                  15      


Ala Pro Pro Gly Val His Arg Arg Tyr Ser Ala Leu Arg Glu Glu Ser 
            20                  25                  30          


Ala Lys Asp Trp Glu Thr Ser Pro Leu Pro Gly Met Leu Ala Pro Ala 
        35                  40                  45              


Ala Gly Pro Ala Phe Asp Ser Asp Pro Glu Ile Ser Asp Val Asp Glu 
    50                  55                  60                  


Asp Glu Pro Gly Gly Leu Val Gly Ser Ala Asp Val Val Ser Pro Ser 
65                  70                  75                  80  


Gly His Ser Asp Ala Gln Thr Leu Ala Met Met Leu Gln Glu Gln Leu 
                85                  90                  95      


Asp Ala Ile Asn Glu Glu Ile Arg Met Ile Gln Glu Glu Lys Glu Ser 
            100                 105                 110         


Thr Glu Leu Arg Ala Glu Glu Ile Glu Thr Arg Val Thr Ser Gly Ser 
        115                 120                 125             


Met Glu Ala Leu Asn Leu Lys Gln Leu Arg Lys Arg Gly Ser Ile Pro 
    130                 135                 140                 


Thr Ser Leu Thr Ala Leu Ser Leu Ala Ser Ala Ser Pro Pro Leu Ser 
145                 150                 155                 160 


Gly Arg Ser Thr Pro Lys Leu Thr Ser Arg Ser Ala Ala Gln Asp Leu 
                165                 170                 175     


Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp Leu Arg Lys His Arg 
            180                 185                 190         


Arg Lys Leu Leu Ser Pro Val Ser Arg Glu Glu Asn Arg Glu Asp Lys 
        195                 200                 205             


Ala Thr Ile Lys Cys Glu Thr Ser Pro Pro Ser Ser Pro Arg Thr Leu 
    210                 215                 220                 


Arg Leu Glu Lys Leu Gly His Pro Ala Leu Ser Gln Glu Glu Gly Lys 
225                 230                 235                 240 


Ser Ala Leu Glu Asp Gln Gly Ser Asn Pro Ser Ser Ser Asn Ser Ser 
                245                 250                 255     


Gln Asp Ser Leu His Lys Gly Ala Lys Arg Lys Gly Ile Lys Ser Ser 
            260                 265                 270         


Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Gly Arg Leu Ile Gln Leu 
        275                 280                 285             


Ser Arg Asp Gly Ala Thr Gly His Val Leu Leu Thr Asp Ser Glu Phe 
    290                 295                 300                 


Ser Met Gln Glu Pro Met Val Pro Ala Lys Leu Gly Thr Gln Ala Glu 
305                 310                 315                 320 


Lys Asp Arg Arg Leu Lys Lys Lys His Gln Leu Leu Glu Asp Ala Arg 
                325                 330                 335     


Arg Lys Gly Met Pro Phe Ala Gln Trp Asp Gly Pro Thr Val Val Ser 
            340                 345                 350         


Trp Leu Glu Leu Trp Val Gly Met Pro Ala Trp Tyr Val Ala Ala Cys 
        355                 360                 365             


Arg Ala Asn Val Lys Ser Gly Ala Ile Met Ser Ala Leu Ser Asp Thr 
    370                 375                 380                 


Glu Ile Gln Arg Glu Ile Gly Ile Ser Asn Ala Leu His Arg Leu Lys 
385                 390                 395                 400 


Leu Arg Leu Ala Ile Gln Glu Met Val Ser Leu Thr Ser Pro Ser Ala 
                405                 410                 415     


Pro Pro Thr Ser Arg Thr Ser Ser Gly Asn Val Trp Val Thr His Glu 
            420                 425                 430         


Glu Met Glu Thr Leu Glu Thr Ser Thr Lys Thr Asp Ser Glu Glu Gly 
        435                 440                 445             


Ser Trp Ala Gln Thr Leu Ala Tyr Gly Asp Met Asn His Glu Trp Ile 
    450                 455                 460                 


Gly Asn Glu Trp Leu Pro Ser Leu Gly Leu Pro Gln Tyr Arg Ser Tyr 
465                 470                 475                 480 


Phe Met Glu Cys Leu Val Asp Ala Arg Met Leu Asp His Leu Thr Lys 
                485                 490                 495     


Lys Asp Leu Arg Val His Leu Lys Met Val Asp Ser Phe His Arg Thr 
            500                 505                 510         


Ser Leu Gln Tyr Gly Ile Met Cys Leu Lys Arg Leu Asn Tyr Asp Arg 
        515                 520                 525             


Lys Glu Leu Glu Lys Arg Arg Glu Glu Ser Gln His Glu Ile Lys Asp 
    530                 535                 540                 


Val Leu Val Trp Thr Asn Asp Gln Val Val His Trp Val Gln Ser Ile 
545                 550                 555                 560 


Gly Leu Arg Asp Tyr Ala Gly Asn Leu His Glu Ser Gly Val His Gly 
                565                 570                 575     


Ala Leu Leu Ala Leu Asp Glu Asn Phe Asp His Asn Thr Leu Ala Leu 
            580                 585                 590         


Ile Leu Gln Ile Pro Thr Gln Asn Thr Gln Ala Arg Gln Val Met Glu 
        595                 600                 605             


Arg Glu Phe Asn Asn Leu Leu Ala Leu Gly Thr Asp Arg Lys Leu Asp 
    610                 615                 620                 


Asp Gly Asp Asp Lys Val Phe Arg Arg Ala Pro Ser Trp Arg Lys Arg 
625                 630                 635                 640 


Phe Arg Pro Arg Glu His His Gly Arg Gly Gly Met Leu Ser Ala Ser 
                645                 650                 655     


Ala Glu Thr Leu Pro Ala Gly Phe Arg Val Ser Thr Leu Gly Thr Leu 
            660                 665                 670         


Gln Pro Pro Pro Ala Pro Pro Lys Lys Ile Met Pro Glu Ala His Ser 
        675                 680                 685             


His Tyr Leu Tyr Gly His Met Leu Ser Ala Phe Arg Asp 
    690                 695                 700     


<210> 5016
<211> 342
<212> PRT
<213> Homo sapiens

<400> 5016
Met Ala Ser Val Thr Arg Ala Val Phe Gly Glu Leu Pro Ser Gly Gly 
1               5                   10                  15      


Gly Thr Val Glu Lys Phe Gln Leu Gln Ser Asp Leu Leu Arg Val Asp 
            20                  25                  30          


Ile Ile Ser Trp Gly Cys Thr Ile Thr Ala Leu Glu Val Lys Asp Arg 
        35                  40                  45              


Gln Gly Arg Ala Ser Asp Val Val Leu Gly Phe Ala Glu Leu Glu Gly 
    50                  55                  60                  


Tyr Leu Gln Lys Gln Pro Tyr Phe Gly Ala Val Ile Gly Arg Val Ala 
65                  70                  75                  80  


Asn Arg Ile Ala Lys Gly Thr Phe Lys Val Asp Gly Lys Glu Tyr His 
                85                  90                  95      


Leu Ala Ile Asn Lys Glu Pro Asn Ser Leu His Gly Gly Val Arg Gly 
            100                 105                 110         


Phe Asp Lys Val Leu Trp Thr Pro Arg Val Leu Ser Asn Gly Val Gln 
        115                 120                 125             


Phe Ser Arg Ile Ser Pro Asp Gly Glu Glu Gly Tyr Pro Gly Glu Leu 
    130                 135                 140                 


Lys Val Trp Val Thr Tyr Thr Leu Asp Gly Gly Glu Leu Ile Val Asn 
145                 150                 155                 160 


Tyr Arg Ala Gln Ala Ser Gln Ala Thr Pro Val Asn Leu Thr Asn His 
                165                 170                 175     


Ser Tyr Phe Asn Leu Ala Gly Gln Ala Ser Pro Asn Ile Asn Asp His 
            180                 185                 190         


Glu Val Thr Ile Glu Ala Asp Thr Tyr Leu Pro Val Asp Glu Thr Leu 
        195                 200                 205             


Ile Pro Thr Gly Glu Val Ala Pro Val Gln Gly Thr Ala Phe Asp Leu 
    210                 215                 220                 


Arg Lys Pro Val Glu Leu Gly Lys His Leu Gln Asp Phe His Leu Asn 
225                 230                 235                 240 


Gly Phe Asp His Asn Phe Cys Leu Lys Gly Ser Lys Glu Lys His Phe 
                245                 250                 255     


Cys Ala Arg Val His His Ala Ala Ser Gly Arg Val Leu Glu Val Tyr 
            260                 265                 270         


Thr Thr Gln Pro Gly Val Gln Phe Tyr Thr Gly Asn Phe Leu Asp Gly 
        275                 280                 285             


Thr Leu Lys Gly Lys Asn Gly Ala Val Tyr Pro Lys His Ser Gly Phe 
    290                 295                 300                 


Cys Leu Glu Thr Gln Asn Trp Pro Asp Ala Val Asn Gln Pro Arg Phe 
305                 310                 315                 320 


Pro Pro Val Leu Leu Arg Pro Gly Glu Glu Tyr Asp His Thr Thr Trp 
                325                 330                 335     


Phe Lys Phe Ser Val Ala 
            340         


<210> 5017
<211> 764
<212> PRT
<213> Homo sapiens

<400> 5017
Met Ser Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Thr Tyr Val 
            20                  25                  30          


Glu Glu Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys 
                85                  90                  95      


Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Glu Val Thr Gln Asp 
            100                 105                 110         


Leu Ile Asp Glu Ser Glu Glu Glu Arg Phe Glu Glu Met Pro Glu Thr 
        115                 120                 125             


Ser His Leu Ile Asp Leu Pro Thr Cys Glu Leu Asn Lys Leu Glu Glu 
    130                 135                 140                 


Ile Ala Asp Leu Val Thr Ser Val Leu Ser Ser Pro Ile Arg Arg Glu 
145                 150                 155                 160 


Lys Leu Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu 
                165                 170                 175     


Gln Leu Phe Gln Ala Cys Glu Asn Leu Glu Asn Thr Glu Gly Leu His 
            180                 185                 190         


His Leu Tyr Glu Ile Ile Arg Gly Ile Leu Phe Leu Asn Lys Ala Thr 
        195                 200                 205             


Leu Phe Glu Val Met Phe Ser Asp Glu Cys Ile Met Asp Val Val Gly 
    210                 215                 220                 


Cys Leu Glu Tyr Asp Pro Ala Leu Ala Gln Pro Lys Arg His Arg Glu 
225                 230                 235                 240 


Phe Leu Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Thr Asp 
                245                 250                 255     


Ser Glu Leu Arg Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile 
            260                 265                 270         


Gln Asp Ile Ile Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Phe Leu 
        275                 280                 285             


Ser Thr Leu Thr Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Ser 
    290                 295                 300                 


Met Leu Gln Glu Asp Glu Lys Phe Leu Ser Glu Val Phe Ala Gln Leu 
305                 310                 315                 320 


Thr Asp Glu Ala Thr Asp Asp Asp Lys Arg Arg Glu Leu Val Asn Phe 
                325                 330                 335     


Phe Lys Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg 
            340                 345                 350         


Asp Ala Phe Phe Lys Thr Leu Ala Lys Leu Gly Ile Leu Pro Ala Leu 
        355                 360                 365             


Glu Ile Val Met Gly Met Asp Asp Leu Gln Val Arg Ser Ala Ala Thr 
    370                 375                 380                 


Asp Ile Phe Ser Tyr Leu Val Glu Phe Ser Pro Ser Met Val Arg Glu 
385                 390                 395                 400 


Phe Val Met Gln Glu Ala Gln Gln Ser Asp Asp Asp Ile Leu Leu Ile 
                405                 410                 415     


Asn Val Val Ile Glu Gln Met Ile Cys Asp Thr Asp Pro Glu Leu Gly 
            420                 425                 430         


Gly Ala Val Gln Leu Met Gly Leu Leu Arg Thr Leu Ile Asp Pro Glu 
        435                 440                 445             


Asn Met Leu Ala Thr Thr Asn Lys Thr Glu Lys Ser Glu Phe Leu Asn 
    450                 455                 460                 


Phe Phe Tyr Asn His Cys Met His Val Leu Thr Ala Pro Leu Leu Thr 
465                 470                 475                 480 


Asn Thr Ser Glu Asp Lys Cys Glu Lys Asp Asn Ile Val Gly Ser Asn 
                485                 490                 495     


Lys Asn Asn Thr Ile Cys Pro Gly Ala Leu Arg Phe Met Arg Arg Ile 
            500                 505                 510         


Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr Ile Thr Lys Gly Asn 
        515                 520                 525             


Leu Phe Glu Pro Val Ile Asn Ala Leu Leu Asp Asn Gly Thr Arg Tyr 
    530                 535                 540                 


Asn Leu Leu Asn Ser Ala Val Ile Glu Leu Phe Glu Phe Ile Arg Val 
545                 550                 555                 560 


Glu Asp Ile Lys Ser Leu Thr Ala His Ile Val Glu Asn Phe Tyr Lys 
                565                 570                 575     


Ala Leu Glu Ser Ile Glu Tyr Val Gln Thr Phe Lys Gly Leu Lys Thr 
            580                 585                 590         


Lys Tyr Glu Gln Glu Lys Asp Arg Gln Asn Gln Lys Leu Asn Ser Val 
        595                 600                 605             


Pro Ser Ile Leu Arg Ser Asn Arg Phe Arg Arg Asp Ala Lys Ala Leu 
    610                 615                 620                 


Glu Glu Asp Glu Glu Met Trp Phe Asn Glu Asp Glu Glu Glu Glu Gly 
625                 630                 635                 640 


Lys Ala Val Val Ala Pro Val Glu Lys Pro Lys Pro Glu Asp Asp Phe 
                645                 650                 655     


Pro Asp Asn Tyr Glu Lys Phe Met Glu Thr Lys Lys Ala Lys Glu Ser 
            660                 665                 670         


Glu Asp Lys Glu Asn Leu Pro Lys Arg Thr Ser Pro Gly Gly Phe Lys 
        675                 680                 685             


Phe Thr Phe Ser His Ser Ala Ser Ala Ala Asn Gly Thr Asn Ser Lys 
    690                 695                 700                 


Ser Val Val Ala Gln Ile Pro Pro Ala Thr Ser Asn Gly Ser Ser Ser 
705                 710                 715                 720 


Lys Thr Thr Asn Leu Pro Thr Ser Val Thr Ala Thr Lys Gly Ser Leu 
                725                 730                 735     


Val Gly Leu Val Asp Tyr Pro Asp Asp Glu Glu Glu Asp Glu Glu Glu 
            740                 745                 750         


Glu Ser Ser Pro Arg Lys Arg Pro Arg Leu Gly Ser 
        755                 760                 


<210> 5018
<211> 76
<212> PRT
<213> Homo sapiens

<400> 5018
Met Ser Lys Ala His Pro Pro Glu Leu Lys Lys Phe Met Asp Lys Lys 
1               5                   10                  15      


Leu Ser Leu Lys Leu Asn Gly Gly Arg His Val Gln Gly Ile Leu Arg 
            20                  25                  30          


Gly Phe Asp Pro Phe Met Asn Leu Val Ile Asp Glu Cys Val Glu Met 
        35                  40                  45              


Ala Thr Ser Gly Gln Gln Asn Asn Ile Gly Met Val Val Ile Arg Gly 
    50                  55                  60                  


Asn Ser Ile Ile Met Leu Glu Ala Leu Glu Arg Val 
65                  70                  75      


<210> 5019
<211> 175
<212> PRT
<213> Homo sapiens

<400> 5019
Met Gln Leu Thr His Gln Leu Asp Leu Phe Pro Glu Cys Arg Val Thr 
1               5                   10                  15      


Leu Leu Leu Phe Lys Asp Val Lys Asn Ala Gly Asp Leu Arg Arg Lys 
            20                  25                  30          


Ala Met Glu Gly Thr Ile Asp Gly Ser Leu Ile Asn Pro Thr Val Ile 
        35                  40                  45              


Val Asp Pro Phe Gln Ile Leu Val Ala Ala Asn Lys Ala Val His Leu 
    50                  55                  60                  


Tyr Lys Leu Gly Lys Met Lys Thr Arg Thr Leu Ser Thr Glu Ile Ile 
65                  70                  75                  80  


Phe Asn Leu Ser Pro Asn Asn Asn Ile Ser Glu Ala Leu Lys Lys Phe 
                85                  90                  95      


Gly Ile Ser Ala Asn Asp Thr Ser Ile Leu Ile Val Tyr Ile Glu Glu 
            100                 105                 110         


Gly Glu Lys Gln Ile Asn Gln Glu Tyr Leu Ile Ser Gln Val Glu Gly 
        115                 120                 125             


His Gln Val Ser Leu Lys Asn Leu Pro Glu Ile Met Asn Ile Thr Glu 
    130                 135                 140                 


Val Lys Lys Ile Tyr Lys Leu Ser Ser Gln Glu Glu Ser Ile Gly Thr 
145                 150                 155                 160 


Leu Leu Asp Ala Ile Ile Cys Arg Met Ser Thr Lys Asp Val Leu 
                165                 170                 175 


<210> 5020
<211> 302
<212> PRT
<213> Homo sapiens

<400> 5020
Met Ala Leu His Asp Met Glu Asp Phe Thr Phe Asp Gly Thr Lys Arg 
1               5                   10                  15      


Leu Ser Val Asn Tyr Val Lys Gly Ile Leu Gln Pro Thr Asp Thr Cys 
            20                  25                  30          


Asp Ile Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu 
        35                  40                  45              


Leu Ile Ser Thr Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln Glu Ile 
    50                  55                  60                  


Val Glu Leu Ile Gln Asn Glu Gly Asp Val Glu Lys Ser Lys Arg Ala 
65                  70                  75                  80  


Pro Thr His Gln Arg Phe Pro Phe Leu Glu Met Lys Ile Pro Ser Leu 
                85                  90                  95      


Gly Ser Gly Leu Glu Gln Ala His Ala Met Pro Ser Pro Arg Ile Leu 
            100                 105                 110         


Lys Thr His Leu Pro Phe His Leu Leu Pro Pro Ser Leu Leu Glu Lys 
        115                 120                 125             


Asn Cys Lys Ile Ile Tyr Val Ala Arg Asn Pro Lys Asp Asn Met Val 
    130                 135                 140                 


Ser Tyr Tyr His Phe Gln Arg Met Asn Lys Ala Leu Pro Ala Pro Gly 
145                 150                 155                 160 


Thr Trp Glu Glu Tyr Phe Glu Thr Phe Leu Ala Gly Lys Val Cys Trp 
                165                 170                 175     


Gly Ser Trp His Glu His Val Lys Gly Trp Trp Glu Ala Lys Asp Lys 
            180                 185                 190         


His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Met Lys Lys Asn Pro Lys 
        195                 200                 205             


His Glu Ile Gln Lys Leu Ala Glu Phe Ile Gly Lys Lys Leu Asp Asp 
    210                 215                 220                 


Lys Val Leu Asp Lys Ile Val His Tyr Thr Ser Phe Asp Val Met Lys 
225                 230                 235                 240 


Gln Asn Pro Met Ala Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met Asp 
                245                 250                 255     


His Ser Ile Ser Pro Phe Met Arg Lys Gly Ala Val Gly Asp Trp Lys 
            260                 265                 270         


Lys His Phe Thr Val Ala Gln Asn Glu Arg Phe Asp Glu Asp Tyr Lys 
        275                 280                 285             


Lys Lys Met Thr Asp Thr Arg Leu Thr Phe His Phe Gln Phe 
    290                 295                 300         


<210> 5021
<211> 963
<212> PRT
<213> Homo sapiens

<400> 5021
Met Trp Cys Leu His Cys Asn Ser Glu Arg Thr Gln Ser Leu Leu Glu 
1               5                   10                  15      


Leu Glu Leu Asp Ser Gly Val Glu Gly Glu Ala Pro Ser Ser Glu Thr 
            20                  25                  30          


Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro Leu Val 
        35                  40                  45              


Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser Val Gly 
    50                  55                  60                  


Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg Thr Arg 
65                  70                  75                  80  


Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln Ala Glu 
                85                  90                  95      


Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr Glu Leu 
            100                 105                 110         


Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg Lys Tyr 
        115                 120                 125             


Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln Thr Ala 
    130                 135                 140                 


Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg Ser Ser 
145                 150                 155                 160 


Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn Met Arg 
                165                 170                 175     


Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser Tyr Phe 
            180                 185                 190         


Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu Gly Ala 
        195                 200                 205             


Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr Leu Lys 
    210                 215                 220                 


Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile Asp Asp 
                245                 250                 255     


Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala Leu Asp 
            260                 265                 270         


Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His Gly Met 
        275                 280                 285             


Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp Val Thr 
    290                 295                 300                 


Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu Ser Gln 
305                 310                 315                 320 


Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu Arg Ala 
                325                 330                 335     


Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu Asp Lys 
            340                 345                 350         


Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu Arg Gln 
        355                 360                 365             


Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile Glu Pro 
    370                 375                 380                 


Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg Gly Ser 
385                 390                 395                 400 


Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln Gln Gly 
                405                 410                 415     


Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu Pro Arg 
            420                 425                 430         


Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp Ser His 
        435                 440                 445             


Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu Ser Asp 
    450                 455                 460                 


Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn Ser Asn 
465                 470                 475                 480 


Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser Leu Arg 
                485                 490                 495     


Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg Asn Ser 
            500                 505                 510         


Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg His Tyr 
        515                 520                 525             


Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly Val Gln 
    530                 535                 540                 


Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly Val Ala 
545                 550                 555                 560 


His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile Gly Glu 
                565                 570                 575     


Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu Asp Cys 
            580                 585                 590         


Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu Ala Leu 
        595                 600                 605             


Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln Lys Val 
    610                 615                 620                 


Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys Asn Pro 
625                 630                 635                 640 


Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile Leu Ala 
                645                 650                 655     


Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn Val Lys 
            660                 665                 670         


Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu Arg Gly 
        675                 680                 685             


Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly Ile Tyr 
    690                 695                 700                 


Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His Val Ser 
705                 710                 715                 720 


Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro Ile Gly 
                725                 730                 735     


Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His Arg Arg 
            740                 745                 750         


Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn Lys Pro 
        755                 760                 765             


Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn Asp Leu 
    770                 775                 780                 


Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val Thr Tyr 
785                 790                 795                 800 


Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu Leu Phe 
                805                 810                 815     


Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser Val Pro 
            820                 825                 830         


Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn Pro Gln 
        835                 840                 845             


Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala Glu Val 
    850                 855                 860                 


Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys Gln Lys 
865                 870                 875                 880 


Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys Lys Glu 
                885                 890                 895     


Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser Tyr Ala 
            900                 905                 910         


Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu Arg Asp 
        915                 920                 925             


Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg Ser Ser Ala Gly Ser Leu 
    930                 935                 940                 


Glu Ser Asn Val Glu Phe Gln Pro Phe Glu Pro Leu Gln Pro Ser Val 
945                 950                 955                 960 


Leu Cys Ser 
            


<210> 5022
<211> 236
<212> PRT
<213> Homo sapiens

<400> 5022
Met Ala Ser Leu Asp Arg Val Lys Val Leu Val Leu Gly Asp Ser Gly 
1               5                   10                  15      


Val Gly Lys Ser Ser Leu Val His Leu Leu Cys Gln Asn Gln Val Leu 
            20                  25                  30          


Gly Asn Pro Ser Trp Thr Val Gly Cys Ser Val Asp Val Arg Val His 
        35                  40                  45              


Asp Tyr Lys Glu Gly Thr Pro Glu Glu Lys Thr Tyr Tyr Ile Glu Leu 
    50                  55                  60                  


Trp Asp Val Gly Gly Ser Val Gly Ser Ala Ser Ser Val Lys Ser Thr 
65                  70                  75                  80  


Arg Ala Val Phe Tyr Asn Ser Val Asn Gly Ile Ile Phe Val His Asp 
                85                  90                  95      


Leu Thr Asn Lys Lys Ser Ser Gln Asn Leu Arg Arg Trp Ser Leu Glu 
            100                 105                 110         


Ala Leu Asn Arg Asp Leu Val Pro Thr Gly Val Leu Val Thr Asn Gly 
        115                 120                 125             


Asp Tyr Asp Gln Glu Gln Phe Ala Asp Asn Gln Ile Pro Leu Leu Val 
    130                 135                 140                 


Ile Gly Thr Lys Leu Asp Gln Ile His Glu Thr Lys Arg His Glu Val 
145                 150                 155                 160 


Leu Thr Arg Thr Ala Phe Leu Ala Glu Asp Phe Asn Pro Glu Glu Ile 
                165                 170                 175     


Asn Leu Asp Cys Thr Asn Pro Arg Tyr Leu Ala Ala Gly Ser Ser Asn 
            180                 185                 190         


Ala Val Lys Leu Ser Arg Phe Phe Asp Lys Val Ile Glu Lys Arg Tyr 
        195                 200                 205             


Phe Leu Arg Glu Gly Asn Gln Ile Pro Gly Phe Pro Asp Arg Lys Arg 
    210                 215                 220                 


Phe Gly Ala Gly Thr Leu Lys Ser Leu His Tyr Asp 
225                 230                 235     


<210> 5023
<211> 927
<212> PRT
<213> Homo sapiens

<400> 5023
Met Gln Ser Ile Leu Tyr His Gly Leu Ile Arg Asp Gln Ala Cys Arg 
1               5                   10                  15      


Arg Gln Thr Asp Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser 
            20                  25                  30          


Pro His Ser Ala Leu His Val Glu Lys Phe Ile Ser Val His Glu Asn 
        35                  40                  45              


Asp Gln Ser Ser Ala Asp Gly Ala Ser Glu Arg Ala Val Ala Glu Leu 
    50                  55                  60                  


Trp Leu Gln His Ser Leu Gln Tyr His Cys Leu Ser Ala Gln Leu Arg 
65                  70                  75                  80  


Pro Leu Leu Gly Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Asp Ala 
                85                  90                  95      


Ala Phe Leu Leu Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu 
            100                 105                 110         


Glu Ala Val Glu Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala 
        115                 120                 125             


Ser Met Phe Ala Arg Lys His Glu Ser Pro Leu Leu Val Thr Lys Ser 
    130                 135                 140                 


Gln Ser Leu Thr Ala Leu Pro Ser Ser Thr Tyr Thr Pro Pro Asn Ser 
145                 150                 155                 160 


Tyr Ala Gln His Ser Tyr Phe Gly Ser Phe Ser Ser Leu His Gln Ser 
                165                 170                 175     


Val Pro Asn Asn Gly Ser Glu Arg Arg Ser Thr Ser Phe Pro Leu Ser 
            180                 185                 190         


Gly Pro Pro Arg Lys Pro Gln Glu Ser Arg Gly His Val Ser Pro Ala 
        195                 200                 205             


Glu Asp Gln Thr Ile Gln Ala Pro Pro Val Ser Val Ser Ala Leu Ala 
    210                 215                 220                 


Arg Asp Ser Pro Leu Thr Pro Asn Glu Met Ser Ser Ser Thr Leu Thr 
225                 230                 235                 240 


Ser Pro Ile Glu Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Gly 
                245                 250                 255     


Asp Ala Ser Glu Gly Pro Glu Tyr Leu Ala Ile Gly Asn Leu Asp Pro 
            260                 265                 270         


Arg Gly Arg Thr Ala Ser Cys Gln Ser His Ser Ser Asn Ala Glu Ser 
        275                 280                 285             


Ser Ser Ser Asn Leu Phe Ser Ser Ser Ser Ser Gln Lys Pro Asp Ser 
    290                 295                 300                 


Ala Ala Ser Ser Leu Gly Asp Gln Glu Gly Gly Gly Glu Ser Gln Leu 
305                 310                 315                 320 


Ser Ser Val Leu Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Leu Thr 
                325                 330                 335     


Val Thr Ser Gly Ala Lys Lys Ser His Ile Arg Ser His Ser Asp Thr 
            340                 345                 350         


Ser Ile Ala Ser Arg Gly Ala Pro Gly Gly Pro Arg Asn Ile Thr Ile 
        355                 360                 365             


Ile Val Glu Asp Pro Ile Ala Glu Ser Cys Asn Asp Lys Ala Lys Leu 
    370                 375                 380                 


Arg Gly Pro Leu Pro Tyr Ser Gly Gln Ser Ser Glu Val Ser Thr Pro 
385                 390                 395                 400 


Ser Ser Leu Tyr Met Glu Tyr Glu Gly Gly Arg Tyr Leu Cys Ser Gly 
                405                 410                 415     


Glu Gly Met Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr 
            420                 425                 430         


Leu Ser Glu Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn 
        435                 440                 445             


Ala His Phe Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met 
    450                 455                 460                 


Lys Cys Asn Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu 
465                 470                 475                 480 


Glu Asp Ser Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu 
                485                 490                 495     


Arg Arg Gln Gln Ile Arg Thr Lys Asn Leu Leu Pro Met Tyr Gln Glu 
            500                 505                 510         


Ala Glu His Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser 
        515                 520                 525             


Ser Arg Asp Ser Ala Gln Leu Ser Asp Ser Gly Ser Ala Asp Glu Val 
    530                 535                 540                 


Asp Glu Phe Glu Ile Gln Asp Ala Asp Ile Arg Arg Asn Thr Ala Ser 
545                 550                 555                 560 


Ser Ser Lys Ser Phe Val Ser Ser Gln Ser Phe Ser His Cys Phe Leu 
                565                 570                 575     


His Ser Thr Ser Ala Glu Ala Val Ala Met Gly Leu Leu Lys Gln Phe 
            580                 585                 590         


Glu Gly Met Gln Leu Pro Ala Ala Ser Glu Leu Glu Trp Leu Val Pro 
        595                 600                 605             


Glu His Asp Ala Pro Gln Lys Leu Leu Pro Ile Pro Asp Ser Leu Pro 
    610                 615                 620                 


Ile Ser Pro Asp Asp Gly Gln His Ala Asp Ile Tyr Lys Leu Arg Ile 
625                 630                 635                 640 


Arg Val Arg Gly Asn Leu Glu Trp Ala Pro Pro Arg Pro Gln Ile Ile 
                645                 650                 655     


Phe Asn Val His Pro Ala Pro Thr Arg Lys Ile Ala Val Ala Lys Gln 
            660                 665                 670         


Asn Tyr Arg Cys Ala Gly Cys Gly Ile Arg Thr Asp Pro Asp Tyr Ile 
        675                 680                 685             


Lys Arg Leu Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Gln Cys 
    690                 695                 700                 


Cys His Glu Asn Ala Gln Met Ala Ile Pro Ser Arg Val Leu Arg Lys 
705                 710                 715                 720 


Trp Asp Phe Ser Lys Tyr Tyr Val Ser Asn Phe Ser Lys Asp Leu Leu 
                725                 730                 735     


Ile Lys Ile Trp Asn Asp Pro Leu Phe Asn Val Gln Asp Ile Asn Ser 
            740                 745                 750         


Ala Leu Tyr Arg Lys Val Lys Leu Leu Asn Gln Val Arg Leu Leu Arg 
        755                 760                 765             


Val Gln Leu Cys His Met Lys Asn Met Phe Lys Thr Cys Arg Leu Ala 
    770                 775                 780                 


Lys Glu Leu Leu Asp Ser Phe Asp Thr Val Pro Gly His Leu Thr Glu 
785                 790                 795                 800 


Asp Leu His Leu Tyr Ser Leu Asn Asp Leu Thr Ala Thr Arg Lys Gly 
                805                 810                 815     


Glu Leu Gly Pro Arg Leu Ala Glu Leu Thr Arg Ala Gly Ala Thr His 
            820                 825                 830         


Val Glu Arg Cys Met Leu Cys Gln Ala Lys Gly Phe Ile Cys Glu Phe 
        835                 840                 845             


Cys Gln Asn Glu Asp Asp Ile Ile Phe Pro Phe Glu Leu His Lys Cys 
    850                 855                 860                 


Arg Thr Cys Glu Glu Cys Lys Ala Cys Tyr His Lys Ala Cys Phe Lys 
865                 870                 875                 880 


Ser Gly Ser Cys Pro Arg Cys Glu Arg Leu Gln Ala Arg Arg Glu Ala 
                885                 890                 895     


Leu Ala Arg Gln Ser Leu Glu Ser Tyr Leu Ser Asp Tyr Glu Glu Glu 
            900                 905                 910         


Pro Ala Glu Ala Leu Ala Leu Glu Ala Ala Val Leu Glu Ala Thr 
        915                 920                 925         


<210> 5024
<211> 99
<212> PRT
<213> Homo sapiens

<400> 5024
Met Ala Ser Ala Ser Ala Arg Gly Asn Gln Asp Lys Asp Ala His Phe 
1               5                   10                  15      


Pro Pro Pro Ser Lys Gln Ser Leu Leu Phe Cys Pro Lys Ser Lys Leu 
            20                  25                  30          


His Ile His Arg Ala Glu Ile Ser Lys Ile Met Arg Glu Cys Gln Glu 
        35                  40                  45              


Glu Ser Phe Trp Lys Arg Ala Leu Pro Phe Ser Leu Val Ser Met Leu 
    50                  55                  60                  


Val Thr Gln Gly Leu Val Tyr Gln Gly Tyr Leu Ala Ala Asn Ser Arg 
65                  70                  75                  80  


Phe Gly Ser Leu Pro Lys Val Ala Arg Thr Ala Ser Leu Pro Val Arg 
                85                  90                  95      


Asn Ala Lys 
            


<210> 5025
<211> 261
<212> PRT
<213> Homo sapiens

<400> 5025
Met Val Val Leu Ser Val Pro Ala Glu Val Thr Val Ile Leu Leu Asp 
1               5                   10                  15      


Ile Glu Gly Thr Thr Thr Pro Ile Ala Phe Val Lys Asp Ile Leu Phe 
            20                  25                  30          


Pro Tyr Ile Glu Glu Asn Val Lys Glu Tyr Leu Gln Thr His Trp Glu 
        35                  40                  45              


Glu Glu Glu Cys Gln Gln Asp Val Ser Leu Leu Arg Lys Gln Ala Glu 
    50                  55                  60                  


Glu Asp Ala His Leu Asp Gly Ala Val Pro Ile Pro Ala Ala Ser Gly 
65                  70                  75                  80  


Asn Gly Val Asp Asp Leu Gln Gln Met Ile Gln Ala Val Val Asp Asn 
                85                  90                  95      


Val Cys Trp Gln Met Ser Leu Asp Arg Lys Thr Thr Ala Leu Lys Gln 
            100                 105                 110         


Leu Gln Gly His Met Trp Arg Ala Ala Phe Thr Ala Gly Arg Met Lys 
        115                 120                 125             


Ala Glu Phe Phe Ala Asp Val Val Pro Ala Val Arg Lys Trp Arg Glu 
    130                 135                 140                 


Ala Gly Met Lys Val Tyr Ile Tyr Ser Ser Gly Ser Val Glu Ala Gln 
145                 150                 155                 160 


Lys Leu Leu Phe Gly His Ser Thr Glu Gly Asp Ile Leu Glu Leu Val 
                165                 170                 175     


Asp Gly His Phe Asp Thr Lys Ile Gly His Lys Val Glu Ser Glu Ser 
            180                 185                 190         


Tyr Arg Lys Ile Ala Asp Ser Ile Gly Cys Ser Thr Asn Asn Ile Leu 
        195                 200                 205             


Phe Leu Thr Asp Val Thr Arg Glu Ala Ser Ala Ala Glu Glu Ala Asp 
    210                 215                 220                 


Val His Val Ala Val Val Val Arg Pro Gly Asn Ala Gly Leu Thr Asp 
225                 230                 235                 240 


Asp Glu Lys Thr Tyr Tyr Ser Leu Ile Thr Ser Phe Ser Glu Leu Tyr 
                245                 250                 255     


Leu Pro Ser Ser Thr 
            260     


<210> 5026
<211> 395
<212> PRT
<213> Homo sapiens

<400> 5026
Met Ala Glu Asp Gly Leu Pro Lys Ile Tyr Ser His Pro Pro Thr Glu 
1               5                   10                  15      


Ser Ser Lys Thr Pro Thr Ala Ala Thr Ile Phe Phe Gly Ala Asp Asn 
            20                  25                  30          


Ala Ile Pro Lys Ser Glu Thr Thr Ile Thr Ser Glu Gly Asp His Val 
        35                  40                  45              


Thr Ser Val Asn Glu Tyr Met Leu Glu Ser Asp Phe Ser Thr Thr Thr 
    50                  55                  60                  


Asp Asn Lys Leu Thr Ala Lys Lys Glu Lys Leu Lys Ser Glu Asp Asp 
65                  70                  75                  80  


Met Gly Thr Asp Phe Ile Lys Ser Thr Thr His Leu Gln Lys Glu Ile 
                85                  90                  95      


Thr Ser Leu Thr Gly Thr Thr Asn Ser Ile Thr Arg Asp Ser Ile Thr 
            100                 105                 110         


Glu His Phe Met Pro Val Lys Ile Gly Asn Ile Ser Ser Pro Val Thr 
        115                 120                 125             


Thr Val Ser Leu Ile Asp Phe Ser Thr Asp Ile Ala Lys Glu Asp Ile 
    130                 135                 140                 


Leu Leu Ala Thr Ile Asp Thr Gly Asp Ala Glu Ile Ser Ile Thr Ser 
145                 150                 155                 160 


Glu Val Ser Gly Thr Leu Lys Asp Ser Ser Ala Gly Val Ala Asp Ala 
                165                 170                 175     


Pro Ala Phe Pro Arg Lys Lys Asp Glu Ala Asp Met Ser Asn Tyr Asn 
            180                 185                 190         


Ser Ser Ile Lys Ser Asn Val Pro Ala Asp Glu Ala Val Gln Val Thr 
        195                 200                 205             


Asp Ser Thr Ile Pro Glu Ala Glu Ile Pro Pro Ala Pro Glu Glu Ser 
    210                 215                 220                 


Phe Thr Thr Ile Pro Asp Ile Thr Ala Leu Glu Glu Glu Lys Ile Thr 
225                 230                 235                 240 


Glu Ile Asp Leu Ser Val Leu Glu Asp Asp Thr Ser Ala Val Ala Thr 
                245                 250                 255     


Leu Thr Asp Ser Asp Glu Lys Phe Ile Thr Val Phe Glu Leu Thr Thr 
            260                 265                 270         


Ser Ala Glu Lys Asp Lys Asp Lys Arg Glu Asp Thr Leu Leu Thr Asp 
        275                 280                 285             


Glu Glu Thr Thr Glu Gly Ala Ser Ile Trp Met Glu Arg Asp Thr Ala 
    290                 295                 300                 


Asn Glu Ala Glu Thr His Ser Val Leu Leu Thr Ala Val Glu Ser Arg 
305                 310                 315                 320 


Tyr Asp Phe Val Val Pro Ala Ser Ile Ala Thr Asn Leu Val Glu Glu 
                325                 330                 335     


Ser Ser Thr Glu Glu Asp Leu Ser Glu Thr Asp Asn Thr Glu Thr Val 
            340                 345                 350         


Pro Lys Ile Thr Glu Pro Phe Ser Gly Thr Thr Ser Val Leu Asp Thr 
        355                 360                 365             


Pro Asp Tyr Lys Glu Asp Thr Ser Thr Thr Glu Thr Asp Ile Phe Glu 
    370                 375                 380                 


Leu Leu Lys Glu Glu Pro Asp Glu Phe Met Ile 
385                 390                 395 


<210> 5027
<211> 306
<212> PRT
<213> Homo sapiens

<400> 5027
Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Arg Asn Ser Lys His Gly Phe Met Thr 
    290                 295                 300                 


Phe Phe 
305     


<210> 5028
<211> 302
<212> PRT
<213> Homo sapiens

<400> 5028
Met Gly Asn Cys Cys Trp Thr Gln Cys Phe Gly Leu Leu Arg Lys Glu 
1               5                   10                  15      


Ala Gly Arg Leu Gln Arg Val Gly Gly Gly Gly Gly Ser Lys Tyr Phe 
            20                  25                  30          


Arg Thr Cys Ser Arg Gly Glu His Leu Thr Ile Glu Phe Glu Asn Leu 
        35                  40                  45              


Val Glu Ser Asp Glu Gly Glu Ser Pro Gly Ser Ser His Arg Pro Leu 
    50                  55                  60                  


Thr Glu Glu Glu Ile Val Asp Leu Arg Glu Arg His Tyr Asp Ser Ile 
65                  70                  75                  80  


Ala Glu Lys Gln Lys Asp Leu Asp Lys Lys Ile Gln Lys Glu Leu Ala 
                85                  90                  95      


Leu Gln Glu Glu Lys Leu Arg Leu Glu Glu Glu Ala Leu Tyr Ala Ala 
            100                 105                 110         


Gln Arg Glu Ala Ala Arg Ala Ala Lys Gln Arg Lys Leu Leu Glu Gln 
        115                 120                 125             


Glu Arg Gln Arg Ile Val Gln Gln Tyr His Pro Ser Asn Asn Gly Glu 
    130                 135                 140                 


Tyr Gln Ser Ser Gly Pro Glu Asp Asp Phe Glu Ser Cys Leu Arg Asn 
145                 150                 155                 160 


Met Lys Ser Gln Tyr Glu Val Phe Arg Ser Ser Arg Leu Ser Ser Asp 
                165                 170                 175     


Ala Thr Val Leu Thr Pro Asn Thr Glu Ser Ser Cys Asp Leu Met Thr 
            180                 185                 190         


Lys Thr Lys Ser Thr Ser Gly Asn Asp Asp Ser Thr Ser Leu Asp Leu 
        195                 200                 205             


Glu Trp Glu Asp Glu Glu Gly Met Asn Arg Met Leu Pro Met Arg Glu 
    210                 215                 220                 


Arg Ser Lys Thr Glu Glu Asp Ile Leu Arg Ala Ala Leu Lys Tyr Ser 
225                 230                 235                 240 


Asn Lys Lys Thr Gly Ser Asn Pro Thr Ser Ala Ser Asp Asp Ser Asn 
                245                 250                 255     


Gly Leu Glu Trp Glu Asn Asp Phe Val Ser Ala Glu Met Asp Asp Asn 
            260                 265                 270         


Gly Asn Ser Glu Tyr Ser Gly Phe Val Asn Pro Val Leu Glu Leu Ser 
        275                 280                 285             


Asp Ser Gly Ile Arg His Ser Asp Thr Asp Gln Gln Thr Arg 
    290                 295                 300         


<210> 5029
<211> 546
<212> PRT
<213> Homo sapiens

<400> 5029
Met Ala Thr Leu Val Val Asn Lys Leu Gly Ala Gly Val Asp Ser Gly 
1               5                   10                  15      


Arg Gln Gly Ser Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly 
            20                  25                  30          


Val Cys Glu Asp Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu 
        35                  40                  45              


Leu Leu Cys Gly His Thr Val Cys His Asp Cys Leu Thr Arg Leu Pro 
    50                  55                  60                  


Leu His Gly Arg Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp 
65                  70                  75                  80  


Leu Gly Asp Ser Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu 
                85                  90                  95      


Glu Leu Leu Glu Arg Leu Gln Asn Gly Pro Ile Gly Gln Tyr Gly Ala 
            100                 105                 110         


Ala Glu Glu Ser Ile Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp 
        115                 120                 125             


Glu Asp Glu Ala His Leu Ala Ser Val Tyr Cys Thr Val Cys Ala Thr 
    130                 135                 140                 


His Leu Cys Ser Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu 
145                 150                 155                 160 


Ala Lys His Arg Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr 
                165                 170                 175     


Met Cys Ser Gln His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu 
            180                 185                 190         


Glu Gly Cys Gln Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr 
        195                 200                 205             


Gly Lys His Gln Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn 
    210                 215                 220                 


Gln Ile Arg Ala Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe 
225                 230                 235                 240 


Thr Glu Glu Ile Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln 
                245                 250                 255     


His Ile Glu Gly Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala 
            260                 265                 270         


His Thr Glu His Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Ile 
        275                 280                 285             


Arg Ala Tyr Phe Tyr Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu 
    290                 295                 300                 


Met Ala Leu Ser Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp 
305                 310                 315                 320 


Leu Arg Gln Gln Gln Glu Asp Met Thr Ile Leu Leu Ser Glu Val Ser 
                325                 330                 335     


Ala Ala Cys Leu His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg 
            340                 345                 350         


Val Val Leu Ala Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln 
        355                 360                 365             


Lys Gln Gln Gln Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp 
    370                 375                 380                 


Ala Ser Ile Pro Val Thr Phe Thr Lys Asp Asn Arg Val His Ile Gly 
385                 390                 395                 400 


Pro Lys Met Glu Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly 
                405                 410                 415     


Lys Thr Thr Ile Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro 
            420                 425                 430         


Ile Pro Thr Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu 
        435                 440                 445             


Lys Phe Thr Ile Trp Asp Val Gly Gly Lys His Lys Leu Arg Pro Leu 
    450                 455                 460                 


Trp Lys His Tyr Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp 
465                 470                 475                 480 


Ser Ser His Arg Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys 
                485                 490                 495     


Leu Leu Thr Glu Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala 
            500                 505                 510         


Asn Lys Gln Asp Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu 
        515                 520                 525             


Leu Leu Ser Leu His Lys Leu Cys Cys Gly Arg Ser Cys Phe Ser Asp 
    530                 535                 540                 


Asn Met 
545     


<210> 5030
<211> 202
<212> PRT
<213> Homo sapiens

<400> 5030
Met Ala Val Pro Ala Ala Leu Ile Leu Arg Glu Ser Pro Ser Met Lys 
1               5                   10                  15      


Lys Ala Val Ser Leu Ile Asn Ala Ile Asp Thr Gly Arg Phe Pro Arg 
            20                  25                  30          


Leu Leu Thr Arg Ile Leu Gln Lys Leu His Leu Lys Ala Glu Ser Ser 
        35                  40                  45              


Phe Ser Glu Glu Glu Glu Glu Lys Leu Gln Ala Ala Phe Ser Leu Glu 
    50                  55                  60                  


Lys Gln Asp Leu His Leu Val Leu Glu Thr Ile Ser Phe Ile Leu Glu 
65                  70                  75                  80  


Gln Ala Val Tyr His Asn Val Lys Pro Ala Ala Leu Gln Gln Gln Leu 
                85                  90                  95      


Glu Asn Ile His Leu Arg Gln Asp Lys Ala Glu Ala Phe Val Asn Thr 
            100                 105                 110         


Trp Ser Ser Met Gly Gln Glu Thr Val Glu Lys Phe Arg Gln Arg Ile 
        115                 120                 125             


Leu Ala Pro Cys Lys Leu Glu Thr Val Gly Trp Gln Leu Asn Leu Gln 
    130                 135                 140                 


Met Ala His Ser Ala Gln Ala Lys Leu Lys Ser Pro Gln Ala Val Leu 
145                 150                 155                 160 


Gln Leu Gly Val Asn Asn Glu Asp Ser Lys Ser Leu Glu Lys Val Leu 
                165                 170                 175     


Val Glu Phe Ser His Lys Glu Leu Phe Asp Phe Tyr Asn Lys Leu Glu 
            180                 185                 190         


Thr Ile Gln Ala Gln Leu Asp Ser Leu Thr 
        195                 200         


<210> 5031
<211> 506
<212> PRT
<213> Homo sapiens

<400> 5031
Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys Met His Leu Glu Lys Leu Glu Glu 
                85                  90                  95      


Gln Leu Ser Arg Ser His Gly Gln Glu Val Asn Glu Leu Lys Thr Lys 
            100                 105                 110         


Ile Glu Lys Leu Lys Val Glu Leu Asp Glu Ala Arg Leu Ser Glu Lys 
        115                 120                 125             


Gln Leu Lys His Gln Val Asp His Gln Lys Glu Leu Leu Ser Cys Lys 
    130                 135                 140                 


Ser Glu Glu Leu Arg Val Met Ser Glu Arg Val Gln Glu Ser Met Ser 
145                 150                 155                 160 


Ser Glu Met Leu Ala Leu Gln Ile Glu Leu Thr Glu Met Glu Ser Met 
                165                 170                 175     


Lys Val Lys Tyr Gln Ser Leu Lys Lys Gln Asn Val Phe Asn Arg Glu 
            180                 185                 190         


Gln Met Gln Arg Met Lys Leu Gln Ile Ala Thr Leu Leu Gln Met Lys 
        195                 200                 205             


Gly Ser Gln Thr Glu Phe Glu Gln Gln Glu Arg Leu Leu Ala Met Leu 
    210                 215                 220                 


Glu Gln Lys Asn Gly Glu Ile Lys His Leu Leu Gly Glu Ile Arg Asn 
225                 230                 235                 240 


Leu Glu Lys Phe Lys Asn Leu Tyr Asp Ser Met Glu Ser Lys Pro Ser 
                245                 250                 255     


Val Asp Ser Gly Thr Leu Glu Asp Asn Thr Tyr Tyr Thr Asp Leu Leu 
            260                 265                 270         


Gln Met Lys Leu Asp Asn Leu Asn Lys Glu Ile Glu Ser Thr Lys Gly 
        275                 280                 285             


Glu Leu Ser Ile Gln Arg Met Lys Ala Leu Phe Glu Ser Gln Arg Ala 
    290                 295                 300                 


Leu Asp Ile Glu Arg Lys Leu Phe Ala Asn Glu Arg Cys Leu Gln Leu 
305                 310                 315                 320 


Ser Glu Ser Glu Asn Met Lys Leu Arg Ala Lys Leu Asp Glu Leu Lys 
                325                 330                 335     


Leu Lys Tyr Glu Pro Glu Glu Thr Val Glu Val Pro Val Leu Lys Lys 
            340                 345                 350         


Arg Arg Glu Val Leu Pro Val Asp Ile Thr Thr Ala Lys Asp Ala Cys 
        355                 360                 365             


Val Asn Asn Ser Ala Leu Gly Gly Glu Val Tyr Arg Leu Pro Pro Gln 
    370                 375                 380                 


Lys Glu Glu Thr Gln Ser Cys Pro Asn Ser Leu Glu Asp Asn Asn Leu 
385                 390                 395                 400 


Gln Leu Glu Lys Ser Val Ser Ile Tyr Thr Pro Val Val Ser Leu Ser 
                405                 410                 415     


Pro His Lys Asn Leu Pro Val Asp Met Gln Leu Lys Lys Glu Lys Lys 
            420                 425                 430         


Cys Val Lys Leu Ile Gly Val Pro Ala Asp Ala Glu Ala Leu Ser Glu 
        435                 440                 445             


Arg Ser Gly Asn Thr Pro Asn Ser Pro Arg Leu Ala Ala Glu Ser Lys 
    450                 455                 460                 


Leu Gln Thr Glu Val Lys Glu Gly Lys Glu Thr Ser Ser Lys Leu Glu 
465                 470                 475                 480 


Lys Glu Thr Cys Lys Lys Leu His Pro Ile Leu Tyr Val Ser Ser Lys 
                485                 490                 495     


Ser Thr Pro Glu Thr Gln Cys Pro Gln Gln 
            500                 505     


<210> 5032
<211> 613
<212> PRT
<213> Homo sapiens

<400> 5032
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 5033
<211> 217
<212> PRT
<213> Homo sapiens

<400> 5033
Met Ser Trp Thr Cys Pro Arg Cys Gln Gln Pro Val Phe Phe Ala Glu 
1               5                   10                  15      


Lys Val Ser Ser Leu Gly Lys Asn Trp His Arg Phe Cys Leu Lys Cys 
            20                  25                  30          


Glu Arg Cys His Ser Ile Leu Ser Pro Gly Gly His Ala Glu His Asn 
        35                  40                  45              


Gly Arg Pro Tyr Cys His Lys Pro Cys Tyr Gly Ala Leu Phe Gly Pro 
    50                  55                  60                  


Arg Gly Val Asn Ile Gly Gly Val Gly Ser Tyr Leu Tyr Asn Pro Pro 
65                  70                  75                  80  


Thr Pro Ser Pro Gly Cys Thr Thr Pro Leu Ser Pro Ser Ser Phe Ser 
                85                  90                  95      


Pro Pro Arg Pro Arg Thr Gly Leu Pro Gln Gly Lys Lys Ser Pro Pro 
            100                 105                 110         


His Met Lys Thr Phe Thr Gly Glu Thr Ser Leu Cys Pro Gly Cys Gly 
        115                 120                 125             


Glu Pro Val Tyr Phe Ala Glu Lys Val Met Ser Leu Gly Arg Asn Trp 
    130                 135                 140                 


His Arg Pro Cys Leu Arg Cys Gln Arg Cys His Lys Thr Leu Thr Ala 
145                 150                 155                 160 


Gly Ser His Ala Glu His Asp Gly Val Pro Tyr Cys His Val Pro Cys 
                165                 170                 175     


Tyr Gly Tyr Leu Phe Gly Pro Lys Gly Gly Gln Pro His Pro Arg His 
            180                 185                 190         


Trp Asp Gly Met Tyr Met Pro Glu Val Trp His Val His Gly Leu Trp 
        195                 200                 205             


Val Cys Val Asp Asn Phe Pro Cys Gly 
    210                 215         


<210> 5034
<211> 500
<212> PRT
<213> Homo sapiens

<400> 5034
Met Asn Gln Arg Arg Ser Glu Ser Arg Pro Gly Asn His Arg Leu Gln 
1               5                   10                  15      


Ala Tyr Ala Glu Pro Gly Lys Gly Asp Ser Gly Gly Ala Gly Pro Leu 
            20                  25                  30          


Ser Gly Ser Ala Arg Arg Gly Arg Gly Gly Gly Gly Ala Ile Arg Val 
        35                  40                  45              


Arg Arg Pro Cys Trp Ser Gly Gly Ala Gly Arg Gly Gly Gly Pro Ala 
    50                  55                  60                  


Trp Ala Val Arg Leu Pro Thr Val Thr Ala Gly Trp Thr Trp Pro Ala 
65                  70                  75                  80  


Leu Arg Thr Leu Ser Ser Leu Arg Ala Gly Pro Ser Glu Pro His Ser 
                85                  90                  95      


Pro Gly Arg Arg Pro Pro Arg Ala Gly Arg Pro Leu Cys Gln Ala Asp 
            100                 105                 110         


Pro Gln Pro Gly Lys Ala Ala Arg Arg Ser Leu Glu Pro Asp Pro Ala 
        115                 120                 125             


Gln Thr Gly Pro Arg Pro Ala Arg Ala Ala Gly Met Ser Glu Ala Arg 
    130                 135                 140                 


Lys Gly Pro Asp Glu Ala Glu Glu Ser Gln Tyr Asp Ser Gly Ile Glu 
145                 150                 155                 160 


Ser Leu Arg Ser Leu Arg Ser Leu Pro Glu Ser Thr Ser Ala Pro Ala 
                165                 170                 175     


Ser Gly Pro Ser Asp Gly Ser Pro Gln Pro Cys Thr His Pro Pro Gly 
            180                 185                 190         


Pro Val Lys Glu Pro Gln Glu Lys Glu Asp Ala Asp Gly Glu Arg Ala 
        195                 200                 205             


Asp Ser Thr Tyr Gly Ser Ser Ser Leu Thr Tyr Thr Leu Ser Leu Leu 
    210                 215                 220                 


Gly Gly Pro Glu Ala Glu Asp Pro Ala Pro Arg Leu Pro Leu Pro His 
225                 230                 235                 240 


Val Gly Ala Leu Ser Pro Gln Gln Leu Glu Ala Leu Thr Tyr Ile Ser 
                245                 250                 255     


Glu Asp Gly Asp Thr Leu Val His Leu Ala Val Ile His Glu Ala Pro 
            260                 265                 270         


Ala Val Leu Leu Cys Cys Leu Ala Leu Leu Pro Gln Glu Val Leu Asp 
        275                 280                 285             


Ile Gln Asn Asn Leu Tyr Gln Thr Ala Leu His Leu Ala Val His Leu 
    290                 295                 300                 


Asp Gln Pro Gly Ala Val Arg Ala Leu Val Leu Lys Gly Ala Ser Arg 
305                 310                 315                 320 


Ala Leu Gln Asp Arg His Gly Asp Thr Ala Leu His Val Ala Cys Gln 
                325                 330                 335     


Arg Gln His Leu Ala Cys Ala Arg Cys Leu Leu Glu Gly Arg Pro Glu 
            340                 345                 350         


Pro Gly Arg Gly Thr Ser His Ser Leu Asp Leu Gln Leu Gln Asn Trp 
        355                 360                 365             


Gln Gly Leu Ala Cys Leu His Ile Ala Thr Leu Gln Lys Asn Gln Pro 
    370                 375                 380                 


Leu Met Glu Leu Leu Leu Arg Asn Gly Ala Asp Ile Asp Val Gln Glu 
385                 390                 395                 400 


Gly Thr Ser Gly Lys Thr Ala Leu His Leu Ala Val Glu Thr Gln Glu 
                405                 410                 415     


Arg Gly Leu Val Gln Phe Leu Leu Gln Ala Gly Ala Gln Val Asp Ala 
            420                 425                 430         


Arg Met Leu Asn Gly Cys Thr Pro Leu His Leu Ala Ala Gly Arg Gly 
        435                 440                 445             


Leu Met Gly Ile Ser Ser Thr Leu Cys Lys Ala Gly Ala Asp Ser Leu 
    450                 455                 460                 


Leu Arg Asn Val Glu Asp Glu Thr Pro Gln Asp Leu Thr Glu Glu Ser 
465                 470                 475                 480 


Leu Val Leu Leu Pro Phe Asp Asp Leu Lys Ile Ser Gly Lys Leu Leu 
                485                 490                 495     


Leu Cys Thr Asp 
            500 


<210> 5035
<211> 626
<212> PRT
<213> Homo sapiens

<400> 5035
Met Glu Gly Pro Arg Glu Asn Gln Asp Pro Pro Pro Arg Ser Leu Ala 
1               5                   10                  15      


Arg His Leu Ser Asp Ala Asp Arg Leu Arg Lys Val Ile Gln Glu Leu 
            20                  25                  30          


Val Asp Thr Glu Lys Ser Tyr Val Lys Asp Leu Ser Cys Leu Phe Glu 
        35                  40                  45              


Leu Tyr Leu Glu Pro Leu Gln Asn Glu Thr Phe Leu Thr Gln Asp Glu 
    50                  55                  60                  


Met Glu Ser Leu Phe Gly Ser Leu Pro Glu Met Leu Glu Phe Gln Lys 
65                  70                  75                  80  


Val Phe Leu Glu Thr Leu Glu Asp Gly Ile Ser Ala Ser Ser Asp Phe 
                85                  90                  95      


Asn Thr Leu Glu Thr Pro Ser Gln Phe Arg Lys Leu Leu Phe Ser Leu 
            100                 105                 110         


Gly Gly Ser Phe Leu Tyr Tyr Ala Asp His Phe Lys Leu Tyr Ser Gly 
        115                 120                 125             


Phe Cys Ala Asn His Ile Lys Val Gln Lys Val Leu Glu Arg Ala Lys 
    130                 135                 140                 


Thr Asp Lys Ala Phe Lys Ala Phe Leu Asp Ala Arg Asn Pro Thr Lys 
145                 150                 155                 160 


Gln His Ser Ser Thr Leu Glu Ser Tyr Leu Ile Lys Pro Val Gln Arg 
                165                 170                 175     


Val Leu Lys Tyr Pro Leu Leu Leu Lys Glu Leu Val Ser Leu Thr Asp 
            180                 185                 190         


Gln Glu Ser Glu Glu His Tyr His Leu Thr Glu Ala Leu Lys Ala Met 
        195                 200                 205             


Glu Lys Val Ala Ser His Ile Asn Glu Met Gln Lys Ile Tyr Glu Asp 
    210                 215                 220                 


Tyr Gly Thr Val Phe Asp Gln Leu Val Ala Glu Gln Ser Gly Thr Glu 
225                 230                 235                 240 


Lys Glu Val Thr Glu Leu Ser Met Gly Glu Leu Leu Met His Ser Thr 
                245                 250                 255     


Val Ser Trp Leu Asn Pro Phe Leu Ser Leu Gly Lys Ala Arg Lys Asp 
            260                 265                 270         


Leu Glu Leu Thr Val Phe Val Phe Lys Arg Ala Val Ile Leu Val Tyr 
        275                 280                 285             


Lys Glu Asn Cys Lys Leu Lys Lys Lys Leu Pro Ser Asn Ser Arg Pro 
    290                 295                 300                 


Ala His Asn Ser Thr Asp Leu Asp Pro Phe Lys Phe Arg Trp Leu Ile 
305                 310                 315                 320 


Pro Ile Ser Ala Leu Gln Val Arg Leu Gly Asn Pro Ala Gly Thr Glu 
                325                 330                 335     


Asn Asn Ser Ile Trp Glu Leu Ile His Thr Lys Ser Glu Ile Glu Gly 
            340                 345                 350         


Arg Pro Glu Thr Ile Phe Gln Leu Cys Cys Ser Asp Ser Glu Ser Lys 
        355                 360                 365             


Thr Asn Ile Val Lys Val Ile Arg Ser Ile Leu Arg Glu Asn Phe Arg 
    370                 375                 380                 


Arg His Ile Lys Cys Glu Leu Pro Leu Glu Lys Thr Cys Lys Asp Arg 
385                 390                 395                 400 


Leu Val Pro Leu Lys Asn Arg Val Pro Val Ser Ala Lys Leu Ala Ser 
                405                 410                 415     


Ser Arg Ser Leu Lys Val Leu Lys Asn Ser Ser Ser Asn Glu Trp Thr 
            420                 425                 430         


Gly Glu Thr Gly Lys Gly Thr Leu Leu Asp Ser Asp Glu Gly Ser Leu 
        435                 440                 445             


Ser Ser Gly Thr Gln Ser Ser Gly Cys Pro Thr Ala Glu Gly Arg Gln 
    450                 455                 460                 


Asp Ser Lys Ser Thr Ser Pro Gly Lys Tyr Pro His Pro Gly Leu Ala 
465                 470                 475                 480 


Asp Phe Ala Asp Asn Leu Ile Lys Glu Ser Asp Ile Leu Ser Asp Glu 
                485                 490                 495     


Asp Asp Asp His Arg Gln Thr Val Lys Gln Gly Ser Pro Thr Lys Asp 
            500                 505                 510         


Ile Glu Ile Gln Phe Gln Arg Leu Arg Ile Ser Glu Asp Pro Asp Val 
        515                 520                 525             


His Pro Glu Ala Glu Gln Gln Pro Gly Pro Glu Ser Gly Glu Gly Gln 
    530                 535                 540                 


Lys Gly Gly Glu Gln Pro Lys Leu Val Arg Gly His Phe Cys Pro Ile 
545                 550                 555                 560 


Lys Arg Lys Ala Asn Ser Thr Lys Arg Asp Arg Gly Thr Leu Leu Lys 
                565                 570                 575     


Ala Gln Ile Arg His Gln Ser Leu Asp Ser Gln Ser Glu Asn Ala Thr 
            580                 585                 590         


Ile Asp Leu Asn Ser Val Leu Glu Arg Glu Phe Ser Val Gln Ser Leu 
        595                 600                 605             


Thr Ser Val Val Ser Glu Glu Cys Phe Tyr Glu Thr Glu Ser His Gly 
    610                 615                 620                 


Lys Ser 
625     


<210> 5036
<211> 531
<212> PRT
<213> Homo sapiens

<400> 5036
Met Ala Ala Val Lys Thr Leu Asn Pro Lys Ala Glu Val Ala Arg Ala 
1               5                   10                  15      


Gln Ala Ala Leu Ala Val Asn Ile Ser Ala Ala Arg Gly Leu Gln Asp 
            20                  25                  30          


Val Leu Arg Thr Asn Leu Gly Pro Lys Gly Thr Met Lys Met Leu Val 
        35                  40                  45              


Ser Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu Leu 
    50                  55                  60                  


His Glu Met Gln Ile Gln His Pro Thr Ala Ser Leu Ile Ala Lys Val 
65                  70                  75                  80  


Ala Thr Ala Gln Asp Asp Ile Thr Gly Asp Gly Thr Thr Ser Asn Val 
                85                  90                  95      


Leu Ile Ile Gly Glu Leu Leu Lys Gln Ala Asp Leu Tyr Ile Ser Glu 
            100                 105                 110         


Gly Leu His Pro Arg Ile Ile Thr Glu Gly Phe Glu Ala Ala Lys Glu 
        115                 120                 125             


Lys Ala Leu Gln Phe Leu Glu Glu Val Lys Val Ser Arg Glu Met Asp 
    130                 135                 140                 


Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg Thr Lys Val 
145                 150                 155                 160 


His Ala Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val Asp Ser Ile 
                165                 170                 175     


Leu Ala Ile Lys Lys Gln Asp Glu Pro Ile Asp Leu Phe Met Ile Glu 
            180                 185                 190         


Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser Leu Ile Arg 
        195                 200                 205             


Gly Leu Val Leu Asp His Gly Ala Arg His Pro Asp Met Lys Lys Arg 
    210                 215                 220                 


Val Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu Glu Tyr Glu 
225                 230                 235                 240 


Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala Glu Glu Arg 
                245                 250                 255     


Glu Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp Arg Val Lys 
            260                 265                 270         


Lys Ile Ile Glu Leu Lys Arg Lys Val Cys Gly Asp Ser Asp Lys Gly 
        275                 280                 285             


Phe Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser Leu Asp Ala 
    290                 295                 300                 


Leu Ser Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys Arg Arg Asn 
305                 310                 315                 320 


Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Val Ala Leu Asn Ser Phe 
                325                 330                 335     


Asp Asp Leu Ser Pro Asp Cys Leu Gly His Ala Gly Leu Val Tyr Glu 
            340                 345                 350         


Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys Cys Asn Asn 
        355                 360                 365             


Pro Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn Lys His Thr Leu 
    370                 375                 380                 


Thr Gln Ile Lys Asp Ala Val Arg Asp Gly Leu Arg Ala Val Lys Asn 
385                 390                 395                 400 


Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala Val Glu Val 
                405                 410                 415     


Ala Met Ala Glu Ala Leu Ile Lys His Lys Pro Ser Val Lys Gly Arg 
            420                 425                 430         


Ala Gln Leu Gly Val Gln Ala Phe Ala Asp Ala Leu Leu Ile Ile Pro 
        435                 440                 445             


Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu Thr Leu Val 
    450                 455                 460                 


Lys Ile Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val Gly Val Asp 
465                 470                 475                 480 


Leu Asn Thr Gly Glu Pro Met Val Ala Ala Glu Val Gly Val Trp Asp 
                485                 490                 495     


Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr Val Ile Ala 
            500                 505                 510         


Thr Asn Ile Leu Leu Val Asp Glu Ile Met Arg Ala Gly Met Ser Ser 
        515                 520                 525             


Leu Lys Gly 
    530     


<210> 5037
<211> 221
<212> PRT
<213> Homo sapiens

<400> 5037
Met Ser Ala Phe Gly His Asp Glu Ala Trp Met Glu Ala Gly Gly Phe 
1               5                   10                  15      


Gly Leu Glu Ala Ala Glu Arg Thr Glu Tyr Gln Ser Leu Cys Lys Ser 
            20                  25                  30          


Lys Leu Leu Phe Leu Gly Glu Gln Ser Gly Lys Thr Ser Ile Ile Ser 
        35                  40                  45              


Arg Phe Met Tyr Asn Ser Phe Gly Cys Ala Cys Gln Ala Thr Val Gly 
    50                  55                  60                  


Ile Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Gln Ile Val Gln 
65                  70                  75                  80  


Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe His Ser Leu Ile 
                85                  90                  95      


Pro Ser Tyr Ile Arg Asp Ser Thr Ile Ala Val Val Val Tyr Asp Ile 
            100                 105                 110         


Thr Asn Ile Asn Ser Phe Lys Glu Thr Asp Lys Trp Val Glu His Val 
        115                 120                 125             


Arg Ala Glu Arg Gly Asp Asp Val Val Ile Met Leu Leu Gly Asn Lys 
    130                 135                 140                 


Ile Asp Leu Asp Asn Lys Arg Gln Val Thr Ala Glu Gln Gly Glu Glu 
145                 150                 155                 160 


Lys Ser Arg Asn Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys Thr 
                165                 170                 175     


Gly Tyr Asn Val Lys Lys Leu Phe Arg Arg Val Ala Ser Ala Leu Leu 
            180                 185                 190         


Ser Thr Arg Thr Ser Pro Pro Pro Lys Glu Gly Thr Val Glu Ile Glu 
        195                 200                 205             


Leu Glu Ser Phe Glu Glu Ser Gly Asn Arg Ser Tyr Cys 
    210                 215                 220     


<210> 5038
<211> 2073
<212> PRT
<213> Homo sapiens

<400> 5038
Met Ala Glu Val Arg Lys Phe Thr Lys Arg Leu Ser Lys Pro Gly Thr 
1               5                   10                  15      


Ala Ala Glu Leu Arg Gln Ser Val Ser Glu Ala Val Arg Gly Ser Val 
            20                  25                  30          


Val Leu Glu Lys Ala Lys Val Val Glu Pro Leu Asp Tyr Glu Asn Val 
        35                  40                  45              


Ile Ala Gln Arg Lys Thr Gln Ile Tyr Ser Asp Pro Leu Arg Asp Leu 
    50                  55                  60                  


Leu Met Phe Pro Met Glu Asp Ile Ser Ile Ser Val Ile Gly Arg Gln 
65                  70                  75                  80  


Arg Arg Thr Val Gln Ser Thr Val Pro Glu Asp Ala Glu Lys Arg Ala 
                85                  90                  95      


Gln Ser Leu Phe Val Lys Glu Cys Ile Lys Thr Tyr Ser Thr Asp Trp 
            100                 105                 110         


His Val Val Asn Tyr Lys Tyr Glu Asp Phe Ser Gly Asp Phe Arg Met 
        115                 120                 125             


Leu Pro Cys Lys Ser Leu Arg Pro Glu Lys Ile Pro Asn His Val Phe 
    130                 135                 140                 


Glu Ile Asp Glu Asp Cys Glu Lys Asp Glu Asp Ser Ser Ser Leu Cys 
145                 150                 155                 160 


Ser Gln Lys Gly Gly Val Ile Lys Gln Gly Trp Leu His Lys Ala Asn 
                165                 170                 175     


Val Asn Ser Thr Ile Thr Val Thr Met Lys Val Phe Lys Arg Arg Tyr 
            180                 185                 190         


Phe Tyr Leu Thr Gln Leu Pro Asp Gly Ser Tyr Ile Leu Asn Ser Tyr 
        195                 200                 205             


Lys Asp Glu Lys Asn Ser Lys Glu Ser Lys Gly Cys Ile Tyr Leu Asp 
    210                 215                 220                 


Ala Cys Ile Asp Val Val Gln Cys Pro Lys Met Arg Arg His Ala Phe 
225                 230                 235                 240 


Glu Leu Lys Met Leu Asp Lys Tyr Ser His Tyr Leu Ala Ala Glu Thr 
                245                 250                 255     


Glu Gln Glu Met Glu Glu Trp Leu Ile Thr Leu Lys Lys Ile Ile Gln 
            260                 265                 270         


Ile Asn Thr Asp Ser Leu Val Gln Glu Lys Lys Glu Thr Val Glu Thr 
        275                 280                 285             


Ala Gln Asp Asp Glu Thr Ser Ser Gln Gly Lys Ala Glu Asn Ile Met 
    290                 295                 300                 


Ala Ser Leu Glu Arg Ser Met His Pro Glu Leu Met Lys Tyr Gly Arg 
305                 310                 315                 320 


Glu Thr Glu Gln Leu Asn Lys Leu Ser Arg Gly Asp Gly Arg Gln Asn 
                325                 330                 335     


Leu Phe Ser Phe Asp Ser Glu Val Gln Arg Leu Asp Phe Ser Gly Ile 
            340                 345                 350         


Glu Pro Asp Ile Lys Pro Phe Glu Glu Lys Cys Asn Lys Arg Phe Leu 
        355                 360                 365             


Val Asn Cys His Asp Leu Thr Phe Asn Ile Leu Gly Gln Ile Gly Asp 
    370                 375                 380                 


Asn Ala Lys Gly Pro Pro Thr Asn Val Glu Pro Phe Phe Ile Asn Leu 
385                 390                 395                 400 


Ala Leu Phe Asp Val Lys Asn Asn Cys Lys Ile Ser Ala Asp Phe His 
                405                 410                 415     


Val Asp Leu Asn Pro Pro Ser Val Arg Glu Met Leu Trp Gly Ser Ser 
            420                 425                 430         


Thr Gln Leu Ala Ser Asp Gly Ser Pro Lys Gly Ser Ser Pro Glu Ser 
        435                 440                 445             


Tyr Ile His Gly Ile Ala Glu Ser Gln Leu Arg Tyr Ile Gln Gln Gly 
    450                 455                 460                 


Ile Phe Ser Val Thr Asn Pro His Pro Glu Ile Phe Leu Val Ala Arg 
465                 470                 475                 480 


Ile Glu Lys Val Leu Gln Gly Asn Ile Thr His Cys Ala Glu Pro Tyr 
                485                 490                 495     


Ile Lys Asn Ser Asp Pro Val Lys Thr Ala Gln Lys Val His Arg Thr 
            500                 505                 510         


Ala Lys Gln Val Cys Ser Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala 
        515                 520                 525             


Trp Ala Ala Arg Pro Ile Phe Lys Asp Thr Gln Gly Ser Leu Asp Leu 
    530                 535                 540                 


Asp Gly Arg Phe Ser Pro Leu Tyr Lys Gln Asp Ser Ser Lys Leu Ser 
545                 550                 555                 560 


Ser Glu Asp Ile Leu Lys Leu Leu Ser Glu Tyr Lys Lys Pro Glu Lys 
                565                 570                 575     


Thr Lys Leu Gln Ile Ile Pro Gly Gln Leu Asn Ile Thr Val Glu Cys 
            580                 585                 590         


Val Pro Val Asp Leu Ser Asn Cys Ile Thr Ser Ser Tyr Val Pro Leu 
        595                 600                 605             


Lys Pro Phe Glu Lys Asn Cys Gln Asn Ile Thr Val Glu Val Glu Glu 
    610                 615                 620                 


Phe Val Pro Glu Met Thr Lys Tyr Cys Tyr Pro Phe Thr Ile Tyr Lys 
625                 630                 635                 640 


Asn His Leu Tyr Val Tyr Pro Leu Gln Leu Lys Tyr Asp Ser Gln Lys 
                645                 650                 655     


Thr Phe Ala Lys Ala Arg Asn Ile Ala Val Cys Val Glu Phe Arg Asp 
            660                 665                 670         


Ser Asp Glu Ser Asp Ala Ser Ala Leu Lys Cys Ile Tyr Gly Lys Pro 
        675                 680                 685             


Ala Gly Ser Val Phe Thr Thr Asn Ala Tyr Ala Val Val Ser His His 
    690                 695                 700                 


Asn Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Ile 
705                 710                 715                 720 


His Leu His Gln Lys His His Leu Leu Phe Thr Phe Tyr His Val Ser 
                725                 730                 735     


Cys Glu Ile Asn Thr Lys Gly Thr Thr Lys Lys Gln Asp Thr Val Glu 
            740                 745                 750         


Thr Pro Val Gly Phe Ala Trp Val Pro Leu Leu Lys Asp Gly Arg Ile 
        755                 760                 765             


Ile Thr Phe Glu Gln Gln Leu Pro Val Ser Ala Asn Leu Pro Pro Gly 
    770                 775                 780                 


Tyr Leu Asn Leu Asn Asp Ala Glu Ser Arg Arg Gln Cys Asn Val Asp 
785                 790                 795                 800 


Ile Lys Trp Val Asp Gly Ala Lys Pro Leu Leu Lys Ile Lys Ser His 
                805                 810                 815     


Leu Glu Ser Thr Ile Tyr Thr Gln Asp Leu His Val His Lys Phe Phe 
            820                 825                 830         


His His Cys Gln Leu Ile Gln Ser Gly Ser Lys Glu Val Pro Gly Glu 
        835                 840                 845             


Leu Ile Lys Tyr Leu Lys Cys Leu His Ala Met Glu Ile Gln Val Met 
    850                 855                 860                 


Ile Gln Phe Leu Pro Val Ile Leu Met Gln Leu Phe Arg Val Leu Thr 
865                 870                 875                 880 


Asn Met Thr His Glu Asp Asp Val Pro Ile Asn Cys Thr Met Val Leu 
                885                 890                 895     


Leu His Ile Val Ser Lys Cys His Glu Glu Gly Leu Asp Ser Tyr Leu 
            900                 905                 910         


Arg Ser Phe Ile Lys Tyr Ser Phe Arg Pro Glu Lys Pro Ser Ala Pro 
        915                 920                 925             


Gln Ala Gln Leu Ile His Glu Thr Leu Ala Thr Thr Met Ile Ala Ile 
    930                 935                 940                 


Leu Lys Gln Ser Ala Asp Phe Leu Ser Ile Asn Lys Leu Leu Lys Tyr 
945                 950                 955                 960 


Ser Trp Phe Phe Phe Glu Ile Ile Ala Lys Ser Met Ala Thr Tyr Leu 
                965                 970                 975     


Leu Glu Glu Asn Lys Ile Lys Leu Pro Arg Gly Gln Arg Phe Pro Glu 
            980                 985                 990         


Thr Tyr His His Val Leu His Ser  Leu Leu Leu Ala Ile  Ile Pro His 
        995                 1000                 1005             


Val Thr  Ile Arg Tyr Ala Glu  Ile Pro Asp Glu Ser  Arg Asn Val 
    1010                 1015                 1020             


Asn Tyr  Ser Leu Ala Ser Phe  Leu Lys Arg Cys Leu  Thr Leu Met 
    1025                 1030                 1035             


Asp Arg  Gly Phe Ile Phe Asn  Leu Ile Asn Asp Tyr  Ile Ser Gly 
    1040                 1045                 1050             


Phe Ser  Pro Lys Asp Pro Lys  Val Leu Ala Glu Tyr  Lys Phe Glu 
    1055                 1060                 1065             


Phe Leu  Gln Thr Ile Cys Asn  His Glu His Tyr Ile  Pro Leu Asn 
    1070                 1075                 1080             


Leu Pro  Met Ala Phe Ala Lys  Pro Lys Leu Gln Arg  Val Gln Asp 
    1085                 1090                 1095             


Ser Asn  Leu Glu Tyr Ser Leu  Ser Asp Glu Tyr Cys  Lys His His 
    1100                 1105                 1110             


Phe Leu  Val Gly Leu Leu Leu  Arg Glu Thr Ser Ile  Ala Leu Gln 
    1115                 1120                 1125             


Asp Asn  Tyr Glu Ile Arg Tyr  Thr Ala Ile Ser Val  Ile Lys Asn 
    1130                 1135                 1140             


Leu Leu  Ile Lys His Ala Phe  Asp Thr Arg Tyr Gln  His Lys Asn 
    1145                 1150                 1155             


Gln Gln  Ala Lys Ile Ala Gln  Leu Tyr Leu Pro Phe  Val Gly Leu 
    1160                 1165                 1170             


Leu Leu  Glu Asn Ile Gln Arg  Leu Ala Gly Arg Asp  Thr Leu Tyr 
    1175                 1180                 1185             


Ser Cys  Ala Ala Met Pro Asn  Ser Ala Ser Arg Asp  Glu Phe Pro 
    1190                 1195                 1200             


Cys Gly  Phe Thr Ser Pro Ala  Asn Arg Gly Ser Leu  Ser Thr Asp 
    1205                 1210                 1215             


Lys Asp  Thr Ala Tyr Gly Ser  Phe Gln Asn Gly His  Gly Ile Lys 
    1220                 1225                 1230             


Arg Glu  Asp Ser Arg Gly Ser  Leu Ile Pro Glu Gly  Ala Thr Gly 
    1235                 1240                 1245             


Phe Pro  Asp Gln Gly Asn Thr  Gly Glu Asn Thr Arg  Gln Ser Ser 
    1250                 1255                 1260             


Thr Arg  Ser Ser Val Ser Gln  Tyr Asn Arg Leu Asp  Gln Tyr Glu 
    1265                 1270                 1275             


Ile Arg  Ser Leu Leu Met Cys  Tyr Leu Tyr Ile Val  Lys Met Ile 
    1280                 1285                 1290             


Ser Glu  Asp Thr Leu Leu Thr  Tyr Trp Asn Lys Val  Ser Pro Gln 
    1295                 1300                 1305             


Glu Leu  Ile Asn Ile Leu Ile  Leu Leu Glu Val Cys  Leu Phe His 
    1310                 1315                 1320             


Phe Arg  Tyr Met Gly Lys Arg  Asn Ile Ala Arg Val  His Asp Ala 
    1325                 1330                 1335             


Trp Leu  Ser Lys His Phe Gly  Ile Asp Arg Lys Ser  Gln Thr Met 
    1340                 1345                 1350             


Pro Ala  Leu Arg Asn Arg Ser  Gly Val Met Gln Ala  Arg Leu Gln 
    1355                 1360                 1365             


His Leu  Ser Ser Leu Glu Ser  Ser Phe Thr Leu Asn  His Ser Ser 
    1370                 1375                 1380             


Thr Thr  Thr Glu Ala Asp Ile  Phe His Gln Ala Leu  Leu Glu Gly 
    1385                 1390                 1395             


Asn Thr  Ala Thr Glu Val Ser  Leu Thr Val Leu Asp  Thr Ile Ser 
    1400                 1405                 1410             


Phe Phe  Thr Gln Cys Phe Lys  Thr Gln Leu Leu Asn  Asn Asp Gly 
    1415                 1420                 1425             


His Asn  Pro Leu Met Lys Lys  Val Phe Asp Ile His  Leu Ala Phe 
    1430                 1435                 1440             


Leu Lys  Asn Gly Gln Ser Glu  Val Ser Leu Lys His  Val Phe Ala 
    1445                 1450                 1455             


Ser Leu  Arg Ala Phe Ile Ser  Lys Phe Pro Ser Ala  Phe Phe Lys 
    1460                 1465                 1470             


Gly Arg  Val Asn Met Cys Ala  Ala Phe Cys Tyr Glu  Val Leu Lys 
    1475                 1480                 1485             


Cys Cys  Thr Ser Lys Ile Ser  Ser Thr Arg Asn Glu  Ala Ser Ala 
    1490                 1495                 1500             


Leu Leu  Tyr Leu Leu Met Arg  Asn Asn Phe Glu Tyr  Thr Lys Arg 
    1505                 1510                 1515             


Lys Thr  Phe Leu Arg Thr His  Leu Gln Ile Ile Ile  Ala Val Ser 
    1520                 1525                 1530             


Gln Leu  Ile Ala Asp Val Ala  Leu Ser Gly Gly Ser  Arg Phe Gln 
    1535                 1540                 1545             


Glu Ser  Leu Phe Ile Ile Asn  Asn Phe Ala Asn Ser  Asp Arg Pro 
    1550                 1555                 1560             


Met Lys  Ala Thr Ala Phe Pro  Ala Glu Val Lys Asp  Leu Thr Lys 
    1565                 1570                 1575             


Arg Ile  Arg Thr Val Leu Met  Ala Thr Ala Gln Met  Lys Glu His 
    1580                 1585                 1590             


Glu Lys  Asp Pro Glu Met Leu  Ile Asp Leu Gln Tyr  Ser Leu Ala 
    1595                 1600                 1605             


Lys Ser  Tyr Ala Ser Thr Pro  Glu Leu Arg Lys Thr  Trp Leu Asp 
    1610                 1615                 1620             


Ser Met  Ala Lys Ile His Val  Lys Asn Gly Asp Phe  Ser Glu Ala 
    1625                 1630                 1635             


Ala Met  Cys Tyr Val His Val  Ala Ala Leu Val Ala  Glu Phe Leu 
    1640                 1645                 1650             


His Arg  Lys Lys Leu Phe Pro  Asn Gly Cys Ser Ala  Phe Lys Lys 
    1655                 1660                 1665             


Ile Thr  Pro Asn Ile Asp Glu  Glu Gly Ala Met Lys  Glu Asp Ala 
    1670                 1675                 1680             


Gly Met  Met Asp Val His Tyr  Ser Glu Glu Val Leu  Leu Glu Leu 
    1685                 1690                 1695             


Leu Glu  Gln Cys Val Asp Gly  Leu Trp Lys Ala Glu  Arg Tyr Glu 
    1700                 1705                 1710             


Ile Ile  Ser Glu Ile Ser Lys  Leu Ile Val Pro Ile  Tyr Glu Lys 
    1715                 1720                 1725             


Arg Arg  Glu Phe Glu Lys Leu  Thr Gln Val Tyr Arg  Thr Leu His 
    1730                 1735                 1740             


Gly Ala  Tyr Thr Lys Ile Leu  Glu Val Met His Thr  Lys Lys Arg 
    1745                 1750                 1755             


Leu Leu  Gly Thr Phe Phe Arg  Val Ala Phe Tyr Gly  Gln Ser Phe 
    1760                 1765                 1770             


Phe Glu  Glu Glu Asp Gly Lys  Glu Tyr Ile Tyr Lys  Glu Pro Lys 
    1775                 1780                 1785             


Leu Thr  Gly Leu Ser Glu Ile  Ser Leu Arg Leu Val  Lys Leu Tyr 
    1790                 1795                 1800             


Gly Glu  Lys Phe Gly Thr Glu  Asn Val Lys Ile Ile  Gln Asp Ser 
    1805                 1810                 1815             


Asp Lys  Val Asn Ala Lys Glu  Leu Asp Pro Lys Tyr  Ala His Ile 
    1820                 1825                 1830             


Gln Val  Thr Tyr Val Lys Pro  Tyr Phe Asp Asp Lys  Glu Leu Thr 
    1835                 1840                 1845             


Glu Arg  Lys Thr Glu Phe Glu  Arg Asn His Asn Ile  Ser Arg Phe 
    1850                 1855                 1860             


Val Phe  Glu Ala Pro Tyr Thr  Leu Ser Gly Lys Lys  Gln Gly Cys 
    1865                 1870                 1875             


Ile Glu  Glu Gln Cys Lys Arg  Arg Thr Ile Leu Thr  Thr Ser Asn 
    1880                 1885                 1890             


Ser Phe  Pro Tyr Val Lys Lys  Arg Ile Pro Ile Asn  Cys Glu Gln 
    1895                 1900                 1905             


Gln Ile  Asn Leu Lys Pro Ile  Asp Val Ala Thr Asp  Glu Ile Lys 
    1910                 1915                 1920             


Asp Lys  Thr Ala Glu Leu Gln  Lys Leu Cys Ser Ser  Thr Asp Val 
    1925                 1930                 1935             


Asp Met  Ile Gln Leu Gln Leu  Lys Leu Gln Gly Cys  Val Ser Val 
    1940                 1945                 1950             


Gln Val  Asn Ala Gly Pro Leu  Ala Tyr Ala Arg Ala  Phe Leu Asn 
    1955                 1960                 1965             


Asp Ser  Gln Ala Ser Lys Tyr  Pro Pro Lys Lys Val  Ser Glu Leu 
    1970                 1975                 1980             


Lys Asp  Met Phe Arg Lys Phe  Ile Gln Ala Cys Ser  Ile Ala Leu 
    1985                 1990                 1995             


Glu Leu  Asn Glu Arg Leu Ile  Lys Glu Asp Gln Val  Glu Tyr His 
    2000                 2005                 2010             


Glu Gly  Leu Lys Ser Asn Phe  Arg Asp Met Val Lys  Glu Leu Ser 
    2015                 2020                 2025             


Asp Ile  Ile His Glu Gln Ile  Leu Gln Glu Asp Thr  Met His Ser 
    2030                 2035                 2040             


Pro Trp  Met Ser Asn Thr Leu  His Val Phe Cys Ala  Ile Ser Gly 
    2045                 2050                 2055             


Thr Ser  Ser Asp Arg Gly Tyr  Gly Ser Pro Arg Tyr  Ala Glu Val 
    2060                 2065                 2070             


<210> 5039
<211> 547
<212> PRT
<213> Homo sapiens

<400> 5039
Met Gly Gly Cys Ile Pro Phe Leu Lys Ala Ala Arg Ala Leu Cys Pro 
1               5                   10                  15      


Arg Ile Met Pro Pro Leu Leu Leu Leu Ser Ala Phe Ile Phe Leu Val 
            20                  25                  30          


Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp Arg Arg Thr Lys 
        35                  40                  45              


Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu Gln 
    50                  55                  60                  


Glu Thr Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu Phe 
65                  70                  75                  80  


Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Thr Leu Asp Lys 
                85                  90                  95      


Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys Thr 
            100                 105                 110         


Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Thr Arg Arg 
        115                 120                 125             


Lys His Leu Glu Leu Thr Ala Thr Met Gln Val Glu Glu Ala Thr Gly 
    130                 135                 140                 


Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe Gly 
145                 150                 155                 160 


Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Thr Leu Pro 
                165                 170                 175     


Arg Glu Phe Thr Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp Ser 
            180                 185                 190         


Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Thr Leu Gln Leu 
        195                 200                 205             


Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys Arg 
    210                 215                 220                 


Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val Glu 
225                 230                 235                 240 


Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly Ile 
                245                 250                 255     


Phe Thr Leu Glu Tyr Ser Val Gln Arg Val Arg Gln Leu Arg Glu Glu 
            260                 265                 270         


Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn Gln Asn Val His 
        275                 280                 285             


Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp Met Lys Asp Ser 
    290                 295                 300                 


Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu Thr Ala Thr Leu 
305                 310                 315                 320 


Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu Val Tyr Leu Met 
                325                 330                 335     


Pro Pro Cys His Ser Asp Thr Leu Glu Arg Leu Leu Lys Ala Leu His 
            340                 345                 350         


Lys Ile Thr Glu Asn Cys Glu Asp Ser Ile Gly Ile Asp Gly Gln Leu 
        355                 360                 365             


Val Pro Gly Asn Arg Met Thr Ser Thr Asn Leu Ala Leu Val Phe Gly 
    370                 375                 380                 


Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg Glu Ser Arg Lys 
385                 390                 395                 400 


Thr Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val Asn Val Val Arg 
                405                 410                 415     


Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val Pro Pro His Ile 
            420                 425                 430         


Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser Pro Glu Ala Leu 
        435                 440                 445             


Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln Ser Ala Arg Ile 
    450                 455                 460                 


Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val Glu Thr Ser Ala 
465                 470                 475                 480 


Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro Ser Asp Glu Gly 
                485                 490                 495     


Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Thr Ala Arg Ser His Asp 
            500                 505                 510         


Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu Gln Asp Arg Pro 
        515                 520                 525             


Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Thr Gly Val Ser Tyr 
    530                 535                 540                 


Phe Phe Pro 
545         


<210> 5040
<211> 1870
<212> PRT
<213> Homo sapiens

<400> 5040
Met Ala Arg Trp Ile Pro Thr Lys Arg Gln Lys Tyr Gly Val Ala Ile 
1               5                   10                  15      


Tyr Asn Tyr Asn Ala Ser Gln Asp Val Glu Leu Ser Leu Gln Ile Gly 
            20                  25                  30          


Asp Thr Val His Ile Leu Glu Met Tyr Glu Gly Trp Tyr Arg Gly Tyr 
        35                  40                  45              


Thr Leu Gln Asn Lys Ser Lys Lys Gly Ile Phe Pro Glu Thr Tyr Ile 
    50                  55                  60                  


His Leu Lys Glu Ala Thr Val Glu Asp Leu Gly Gln His Glu Thr Val 
65                  70                  75                  80  


Ile Pro Gly Glu Leu Pro Leu Val Gln Glu Leu Thr Ser Thr Leu Arg 
                85                  90                  95      


Glu Trp Ala Val Ile Trp Arg Lys Leu Tyr Val Asn Asn Lys Leu Thr 
            100                 105                 110         


Leu Phe Arg Gln Leu Gln Gln Met Thr Tyr Ser Leu Ile Glu Trp Arg 
        115                 120                 125             


Ser Gln Ile Leu Ser Gly Thr Leu Pro Lys Asp Glu Leu Ala Glu Leu 
    130                 135                 140                 


Lys Lys Lys Val Thr Ala Lys Ile Asp His Gly Asn Arg Met Leu Gly 
145                 150                 155                 160 


Leu Asp Leu Val Val Arg Asp Asp Asn Gly Asn Ile Leu Asp Pro Asp 
                165                 170                 175     


Glu Thr Ser Thr Ile Ala Leu Phe Lys Ala His Glu Val Ala Ser Lys 
            180                 185                 190         


Arg Ile Glu Glu Lys Ile Gln Glu Glu Lys Ser Ile Leu Gln Asn Leu 
        195                 200                 205             


Asp Leu Arg Gly Gln Ser Ile Phe Ser Thr Ile His Thr Tyr Gly Leu 
    210                 215                 220                 


Tyr Val Asn Phe Lys Asn Phe Val Cys Asn Ile Gly Glu Asp Ala Glu 
225                 230                 235                 240 


Leu Phe Met Ala Leu Tyr Asp Pro Asp Gln Ser Thr Phe Ile Ser Glu 
                245                 250                 255     


Asn Tyr Leu Ile Arg Trp Gly Ser Asn Gly Met Pro Lys Glu Ile Glu 
            260                 265                 270         


Lys Leu Asn Asn Leu Gln Ala Val Phe Thr Asp Leu Ser Ser Met Asp 
        275                 280                 285             


Leu Ile Arg Pro Arg Val Ser Leu Val Cys Gln Ile Val Arg Val Gly 
    290                 295                 300                 


His Met Glu Leu Lys Glu Gly Lys Lys His Thr Cys Gly Leu Arg Arg 
305                 310                 315                 320 


Pro Phe Gly Val Ala Val Met Asp Ile Thr Asp Ile Ile His Gly Lys 
                325                 330                 335     


Val Asp Asp Glu Glu Lys Gln His Phe Ile Pro Phe Gln Gln Ile Ala 
            340                 345                 350         


Met Glu Thr Tyr Ile Arg Gln Arg Gln Leu Ile Met Ser Pro Leu Ile 
        355                 360                 365             


Thr Ser His Val Ile Gly Glu Asn Glu Pro Leu Thr Ser Val Leu Asn 
    370                 375                 380                 


Lys Val Ile Ala Ala Lys Glu Val Asn His Lys Gly Gln Gly Leu Trp 
385                 390                 395                 400 


Val Ser Leu Lys Leu Leu Pro Gly Asp Leu Thr Gln Val Gln Lys Asn 
                405                 410                 415     


Phe Ser His Leu Val Asp Arg Ser Thr Ala Ile Ala Arg Lys Met Gly 
            420                 425                 430         


Phe Pro Glu Ile Ile Leu Pro Gly Asp Val Arg Asn Asp Ile Tyr Val 
        435                 440                 445             


Thr Leu Ile His Gly Glu Phe Asp Lys Gly Lys Lys Lys Thr Pro Lys 
    450                 455                 460                 


Asn Val Glu Val Thr Met Ser Val His Asp Glu Glu Gly Lys Leu Leu 
465                 470                 475                 480 


Glu Lys Ala Ile His Pro Gly Ala Gly Tyr Glu Gly Ile Ser Glu Tyr 
                485                 490                 495     


Lys Ser Val Val Tyr Tyr Gln Val Lys Gln Pro Cys Trp Tyr Glu Thr 
            500                 505                 510         


Val Lys Val Ser Ile Ala Ile Glu Glu Val Thr Arg Cys His Ile Arg 
        515                 520                 525             


Phe Thr Phe Arg His Arg Ser Ser Gln Glu Thr Arg Asp Lys Ser Glu 
    530                 535                 540                 


Arg Ala Phe Gly Val Ala Phe Val Lys Leu Met Asn Pro Asp Gly Thr 
545                 550                 555                 560 


Thr Leu Gln Asp Gly Arg His Asp Leu Val Val Tyr Lys Gly Asp Asn 
                565                 570                 575     


Lys Lys Met Glu Asp Ala Lys Phe Tyr Leu Thr Leu Pro Gly Thr Lys 
            580                 585                 590         


Met Glu Met Glu Glu Lys Glu Leu Gln Ala Ser Lys Asn Leu Val Thr 
        595                 600                 605             


Phe Thr Pro Ser Lys Asp Ser Thr Lys Asp Ser Phe Gln Ile Ala Thr 
    610                 615                 620                 


Leu Ile Cys Ser Thr Lys Leu Thr Gln Asn Val Asp Leu Leu Gly Leu 
625                 630                 635                 640 


Leu Asn Trp Arg Ser Asn Ser Gln Asn Ile Lys His Asn Leu Lys Lys 
                645                 650                 655     


Leu Met Glu Val Asp Gly Gly Glu Ile Val Lys Phe Leu Gln Asp Thr 
            660                 665                 670         


Leu Asp Ala Leu Phe Asn Ile Met Met Glu Met Ser Asp Ser Glu Thr 
        675                 680                 685             


Tyr Asp Phe Leu Val Phe Asp Ala Leu Val Phe Ile Ile Ser Leu Ile 
    690                 695                 700                 


Gly Asp Ile Lys Phe Gln His Phe Asn Pro Val Leu Glu Thr Tyr Ile 
705                 710                 715                 720 


Tyr Lys His Phe Ser Ala Thr Leu Ala Tyr Val Lys Leu Ser Lys Val 
                725                 730                 735     


Leu Asn Phe Tyr Val Ala Asn Ala Asp Asp Ser Ser Lys Thr Glu Leu 
            740                 745                 750         


Leu Phe Ala Ala Leu Lys Ala Leu Lys Tyr Leu Phe Arg Phe Ile Ile 
        755                 760                 765             


Gln Ser Arg Val Leu Tyr Leu Arg Phe Tyr Gly Gln Ser Lys Asp Gly 
    770                 775                 780                 


Asp Glu Phe Asn Asn Ser Ile Arg Gln Leu Phe Leu Ala Phe Asn Met 
785                 790                 795                 800 


Leu Met Asp Arg Pro Leu Glu Glu Ala Val Lys Ile Lys Gly Ala Ala 
                805                 810                 815     


Leu Lys Tyr Leu Pro Ser Ile Ile Asn Asp Val Lys Leu Val Phe Asp 
            820                 825                 830         


Pro Val Glu Leu Ser Val Leu Phe Cys Lys Phe Ile Gln Ser Ile Pro 
        835                 840                 845             


Asp Asn Gln Leu Val Arg Gln Lys Leu Asn Cys Met Thr Lys Ile Val 
    850                 855                 860                 


Glu Ser Thr Leu Phe Arg Gln Ser Glu Cys Arg Glu Val Leu Leu Pro 
865                 870                 875                 880 


Leu Leu Thr Asp Gln Leu Ser Gly Gln Leu Asp Asp Asn Ser Asn Lys 
                885                 890                 895     


Pro Asp His Glu Ala Ser Ser Gln Leu Leu Ser Asn Ile Leu Glu Val 
            900                 905                 910         


Leu Asp Arg Lys Asp Val Gly Ala Thr Ala Val His Ile Gln Leu Ile 
        915                 920                 925             


Met Glu Arg Leu Leu Arg Arg Ile Asn Arg Thr Val Ile Gly Met Asn 
    930                 935                 940                 


Arg Gln Ser Pro His Ile Gly Ser Phe Val Ala Cys Met Ile Ala Leu 
945                 950                 955                 960 


Leu Gln Gln Met Asp Asp Ser His Tyr Ser His Tyr Ile Ser Thr Phe 
                965                 970                 975     


Lys Thr Arg Gln Asp Ile Ile Asp Phe Leu Met Glu Thr Phe Ile Met 
            980                 985                 990         


Phe Lys Asp Leu Ile Gly Lys Asn  Val Tyr Ala Lys Asp  Trp Met Val 
        995                 1000                 1005             


Met Asn  Met Thr Gln Asn Arg  Val Phe Leu Arg Ala  Ile Asn Gln 
    1010                 1015                 1020             


Phe Ala  Glu Val Leu Thr Arg  Phe Phe Met Asp Gln  Ala Ser Phe 
    1025                 1030                 1035             


Glu Leu  Gln Leu Trp Asn Asn  Tyr Phe His Leu Ala  Val Ala Phe 
    1040                 1045                 1050             


Leu Thr  His Glu Ser Leu Gln  Leu Glu Thr Phe Ser  Gln Ala Lys 
    1055                 1060                 1065             


Arg Asn  Lys Ile Val Lys Lys  Tyr Gly Asp Met Arg  Lys Glu Ile 
    1070                 1075                 1080             


Gly Phe  Arg Ile Arg Asp Met  Trp Tyr Asn Leu Gly  Pro His Lys 
    1085                 1090                 1095             


Ile Lys  Phe Ile Pro Ser Met  Val Gly Pro Ile Leu  Glu Val Thr 
    1100                 1105                 1110             


Leu Thr  Pro Glu Val Glu Leu  Arg Lys Ala Thr Ile  Pro Ile Phe 
    1115                 1120                 1125             


Phe Asp  Met Met Gln Cys Glu  Phe Asn Phe Ser Gly  Asn Gly Asn 
    1130                 1135                 1140             


Phe His  Met Phe Glu Asn Glu  Leu Ile Thr Lys Leu  Asp Gln Glu 
    1145                 1150                 1155             


Val Glu  Gly Gly Arg Gly Asp  Glu Gln Tyr Lys Val  Leu Leu Glu 
    1160                 1165                 1170             


Lys Leu  Leu Leu Glu His Cys  Arg Lys His Lys Tyr  Leu Ser Ser 
    1175                 1180                 1185             


Ser Gly  Glu Val Phe Ala Leu  Leu Val Ser Ser Leu  Leu Glu Asn 
    1190                 1195                 1200             


Leu Leu  Asp Tyr Arg Thr Ile  Ile Met Gln Asp Glu  Ser Lys Glu 
    1205                 1210                 1215             


Asn Arg  Met Ser Cys Thr Val  Asn Val Leu Asn Phe  Tyr Lys Glu 
    1220                 1225                 1230             


Lys Lys  Arg Glu Asp Ile Tyr  Ile Arg Tyr Leu Tyr  Lys Leu Arg 
    1235                 1240                 1245             


Asp Leu  His Arg Asp Cys Glu  Asn Tyr Thr Glu Ala  Ala Tyr Thr 
    1250                 1255                 1260             


Leu Leu  Leu His Ala Glu Leu  Leu Gln Trp Ser Asp  Lys Pro Cys 
    1265                 1270                 1275             


Val Pro  His Leu Leu Gln Lys  Asp Ser Tyr Tyr Val  Tyr Thr Gln 
    1280                 1285                 1290             


Gln Glu  Leu Lys Glu Lys Leu  Tyr Gln Glu Ile Ile  Ser Tyr Phe 
    1295                 1300                 1305             


Asp Lys  Gly Lys Met Trp Glu  Lys Ala Ile Lys Leu  Ser Lys Glu 
    1310                 1315                 1320             


Leu Ala  Glu Thr Tyr Glu Ser  Lys Val Phe Asp Tyr  Glu Gly Leu 
    1325                 1330                 1335             


Gly Asn  Leu Leu Lys Lys Arg  Ala Ser Phe Tyr Glu  Asn Ile Ile 
    1340                 1345                 1350             


Lys Ala  Met Arg Pro Gln Pro  Glu Tyr Phe Ala Val  Gly Tyr Tyr 
    1355                 1360                 1365             


Gly Gln  Gly Phe Pro Ser Phe  Leu Arg Asn Lys Ile  Phe Ile Tyr 
    1370                 1375                 1380             


Arg Gly  Lys Glu Tyr Glu Arg  Arg Glu Asp Phe Ser  Leu Arg Leu 
    1385                 1390                 1395             


Leu Thr  Gln Phe Pro Asn Ala  Glu Lys Met Thr Ser  Thr Thr Pro 
    1400                 1405                 1410             


Pro Gly  Glu Asp Ile Lys Ser  Ser Pro Lys Gln Tyr  Met Gln Cys 
    1415                 1420                 1425             


Phe Thr  Val Lys Pro Val Met  Ser Leu Pro Pro Ser  Tyr Lys Asp 
    1430                 1435                 1440             


Lys Pro  Val Pro Glu Gln Ile  Leu Asn Tyr Tyr Arg  Ala Asn Glu 
    1445                 1450                 1455             


Val Gln  Gln Phe Arg Tyr Ser  Arg Pro Phe Arg Lys  Gly Glu Lys 
    1460                 1465                 1470             


Asp Pro  Asp Asn Glu Phe Ala  Thr Met Trp Ile Glu  Arg Thr Thr 
    1475                 1480                 1485             


Tyr Thr  Thr Ala Tyr Thr Phe  Pro Gly Ile Leu Lys  Trp Phe Glu 
    1490                 1495                 1500             


Val Lys  Gln Ile Ser Thr Glu  Glu Ile Ser Pro Leu  Glu Asn Ala 
    1505                 1510                 1515             


Ile Glu  Thr Met Glu Leu Thr  Asn Glu Arg Ile Ser  Asn Cys Val 
    1520                 1525                 1530             


Gln Gln  His Ala Trp Asp Arg  Ser Leu Ser Val His  Pro Leu Ser 
    1535                 1540                 1545             


Met Leu  Leu Ser Gly Ile Val  Asp Pro Ala Val Met  Gly Gly Phe 
    1550                 1555                 1560             


Ser Asn  Tyr Glu Lys Ala Phe  Phe Thr Glu Lys Tyr  Leu Gln Glu 
    1565                 1570                 1575             


His Pro  Glu Asp Gln Glu Lys  Val Glu Leu Leu Lys  Arg Leu Ile 
    1580                 1585                 1590             


Ala Leu  Gln Met Pro Leu Leu  Thr Glu Gly Ile Arg  Ile His Gly 
    1595                 1600                 1605             


Glu Lys  Leu Thr Glu Gln Leu  Lys Pro Leu His Glu  Arg Leu Ser 
    1610                 1615                 1620             


Ser Cys  Phe Arg Glu Leu Lys  Glu Lys Val Glu Lys  His Tyr Gly 
    1625                 1630                 1635             


Val Ile  Thr Leu Pro Pro Asn  Leu Thr Glu Arg Lys  Gln Ser Arg 
    1640                 1645                 1650             


Thr Gly  Ser Ile Val Leu Pro  Tyr Ile Met Ser Ser  Thr Leu Arg 
    1655                 1660                 1665             


Arg Leu  Ser Ile Thr Ser Val  Thr Ser Ser Val Val  Ser Thr Ser 
    1670                 1675                 1680             


Ser Asn  Ser Ser Asp Asn Ala  Pro Ser Arg Pro Gly  Ser Asp Gly 
    1685                 1690                 1695             


Ser Ile  Leu Glu Pro Leu Leu  Glu Arg Arg Ala Ser  Ser Gly Ala 
    1700                 1705                 1710             


Arg Val  Glu Asp Leu Ser Leu  Arg Glu Glu Asn Ser  Glu Asn Arg 
    1715                 1720                 1725             


Ile Ser  Lys Phe Lys Arg Lys  Asp Trp Ser Leu Ser  Lys Ser Gln 
    1730                 1735                 1740             


Val Ile  Ala Glu Lys Ala Pro  Glu Pro Asp Leu Met  Ser Pro Thr 
    1745                 1750                 1755             


Arg Lys  Ala Gln Arg Pro Lys  Ser Leu Gln Leu Met  Asp Asn Arg 
    1760                 1765                 1770             


Leu Ser  Pro Phe His Gly Ser  Ser Pro Pro Gln Ser  Thr Pro Leu 
    1775                 1780                 1785             


Ser Pro  Pro Pro Leu Thr Pro  Lys Ala Thr Arg Thr  Leu Ser Ser 
    1790                 1795                 1800             


Pro Ser  Leu Gln Thr Asp Gly  Ile Ala Ala Thr Pro  Val Pro Pro 
    1805                 1810                 1815             


Pro Pro  Pro Pro Lys Ser Lys  Pro Tyr Glu Gly Ser  Gln Arg Asn 
    1820                 1825                 1830             


Ser Thr  Glu Leu Ala Pro Pro  Leu Pro Val Arg Arg  Glu Ala Lys 
    1835                 1840                 1845             


Ala Pro  Pro Pro Pro Pro Pro  Lys Ala Arg Lys Ser  Gly Ile Pro 
    1850                 1855                 1860             


Thr Ser  Glu Pro Gly Ser Gln  
    1865                 1870 


<210> 5041
<211> 540
<212> PRT
<213> Homo sapiens

<400> 5041
Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 
1               5                   10                  15      


Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
            20                  25                  30          


Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
        35                  40                  45              


Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 
    50                  55                  60                  


Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 
65                  70                  75                  80  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
                85                  90                  95      


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
            100                 105                 110         


Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 
        115                 120                 125             


Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 
    130                 135                 140                 


Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 
145                 150                 155                 160 


Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 
                165                 170                 175     


Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 
            180                 185                 190         


Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 
        195                 200                 205             


Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 
    210                 215                 220                 


Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 
225                 230                 235                 240 


Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 
                245                 250                 255     


Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 
            260                 265                 270         


Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 
        275                 280                 285             


Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 
    290                 295                 300                 


Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 
305                 310                 315                 320 


Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 
                325                 330                 335     


Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 
            340                 345                 350         


Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 
        355                 360                 365             


Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 
    370                 375                 380                 


Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 
385                 390                 395                 400 


Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Gly Glu Val Val 
                405                 410                 415     


Pro Thr Gly Ser Glu Gln Thr Thr Glu Ser Glu Thr Pro Val Pro Ala 
            420                 425                 430         


Ala Ala Glu Thr Ala Asp Pro Leu Phe Tyr Pro Ser Trp Tyr Lys Gly 
        435                 440                 445             


Gln Thr Arg Lys Ala Thr Thr Asn Pro Pro Cys Thr Pro Gly Ser Glu 
    450                 455                 460                 


Gly Leu Gly Gln Ile Gly Pro Pro Gly Ser Glu Asp Ser Asn Val Arg 
465                 470                 475                 480 


Lys Ala Glu Val Ala Ala Ala Ala Ala Ser Glu Arg Ala Ala Val Ser 
                485                 490                 495     


Gly Lys Glu Thr Ser Ala Pro Ala Ala Thr Ser Gln Glu Leu Val Ile 
            500                 505                 510         


Cys Leu Ala Leu Leu Ala Phe Leu Ile Leu His Tyr Ile Trp Ser Gln 
        515                 520                 525             


Ile Gln Cys Leu Ile Phe Thr Leu Met Asp Trp Ile 
    530                 535                 540 


<210> 5042
<211> 1083
<212> PRT
<213> Homo sapiens

<400> 5042
Met Ser Gln Thr Gln Asp Tyr Glu Cys Arg Ser His Asn Val Asp Leu 
1               5                   10                  15      


Pro Glu Ser Arg Ile Pro Gly Ser Asn Thr Arg Leu Glu Trp Val Glu 
            20                  25                  30          


Ile Ile Glu Pro Arg Thr Arg Glu Arg Met Tyr Ala Asn Leu Val Thr 
        35                  40                  45              


Gly Glu Cys Val Trp Asp Pro Pro Ala Gly Val Arg Ile Lys Arg Thr 
    50                  55                  60                  


Ser Glu Asn Gln Trp Trp Glu Leu Phe Asp Pro Asn Thr Ser Arg Phe 
65                  70                  75                  80  


Tyr Tyr Tyr Asn Ala Ser Thr Gln Arg Thr Val Trp His Arg Pro Gln 
                85                  90                  95      


Gly Cys Asp Ile Ile Pro Leu Ala Lys Leu Gln Thr Leu Lys Gln Asn 
            100                 105                 110         


Thr Glu Ser Pro Arg Ala Ser Ala Glu Ser Ser Pro Gly Arg Gly Ser 
        115                 120                 125             


Ser Val Ser Arg Glu Gly Ser Thr Ser Ser Ser Leu Glu Pro Glu Pro 
    130                 135                 140                 


Asp Thr Glu Lys Ala Gln Glu Leu Pro Ala Arg Ala Gly Arg Pro Ala 
145                 150                 155                 160 


Ala Phe Gly Thr Val Lys Glu Asp Ser Gly Ser Ser Ser Pro Pro Gly 
                165                 170                 175     


Val Phe Leu Glu Lys Asp Tyr Glu Ile Tyr Arg Asp Tyr Ser Ala Asp 
            180                 185                 190         


Gly Gln Leu Leu His Tyr Arg Thr Ser Ser Leu Arg Trp Asn Ser Gly 
        195                 200                 205             


Ala Lys Glu Arg Met Leu Ile Lys Val Ala Asp Arg Glu Pro Ser Phe 
    210                 215                 220                 


Leu Ala Ala Gln Gly Asn Gly Tyr Ala Pro Asp Gly Pro Pro Gly Val 
225                 230                 235                 240 


Arg Ser Arg Arg Pro Ser Gly Ser Gln His Ser Pro Ser Leu Gln Thr 
                245                 250                 255     


Phe Ala Pro Glu Ala Asp Gly Thr Ile Phe Phe Pro Glu Arg Arg Pro 
            260                 265                 270         


Ser Pro Phe Leu Lys Arg Ala Glu Leu Pro Gly Ser Ser Ser Pro Leu 
        275                 280                 285             


Leu Ala Gln Pro Arg Lys Pro Ser Gly Asp Ser Gln Pro Ser Ser Pro 
    290                 295                 300                 


Arg Tyr Gly Tyr Glu Pro Pro Leu Tyr Glu Glu Pro Pro Val Glu Tyr 
305                 310                 315                 320 


Gln Ala Pro Ile Tyr Asp Glu Pro Pro Met Asp Val Gln Phe Glu Ala 
                325                 330                 335     


Gly Gly Gly Tyr Gln Ala Gly Ser Pro Gln Arg Ser Pro Gly Arg Lys 
            340                 345                 350         


Pro Arg Pro Phe Leu Gln Pro Asn Lys Gln Gly Pro Pro Ser Pro Cys 
        355                 360                 365             


Gln Gln Leu Val Leu Thr Lys Gln Lys Cys Pro Glu Arg Phe Leu Ser 
    370                 375                 380                 


Leu Glu Tyr Ser Pro Ala Gly Lys Glu Tyr Val Arg Gln Leu Val Tyr 
385                 390                 395                 400 


Val Glu Gln Ala Gly Ser Ser Pro Lys Leu Arg Ala Gly Pro Arg His 
                405                 410                 415     


Lys Tyr Ala Pro Asn Pro Gly Gly Gly Ser Tyr Ser Leu Gln Pro Ser 
            420                 425                 430         


Pro Cys Leu Leu Arg Asp Gln Arg Leu Gly Val Lys Ser Gly Asp Tyr 
        435                 440                 445             


Ser Thr Met Glu Gly Pro Glu Leu Arg His Ser Gln Pro Pro Thr Pro 
    450                 455                 460                 


Leu Pro Gln Ala Gln Glu Asp Ala Met Ser Trp Ser Ser Gln Gln Asp 
465                 470                 475                 480 


Thr Leu Ser Ser Thr Gly Tyr Ser Pro Gly Thr Arg Lys Arg Lys Ser 
                485                 490                 495     


Arg Lys Pro Ser Leu Cys Gln Ala Thr Ser Ala Thr Pro Thr Glu Gly 
            500                 505                 510         


Pro Gly Asp Leu Leu Val Glu Gln Pro Leu Ala Glu Glu Gln Pro Pro 
        515                 520                 525             


Cys Gly Thr Ser Leu Ala Pro Val Lys Arg Ala Glu Gly Glu Ala Glu 
    530                 535                 540                 


Gly Ala Arg Gly Ala Ala Glu Pro Phe Leu Ala Gln Ala Arg Leu Ala 
545                 550                 555                 560 


Trp Glu Ala Gln Gln Ala His Phe His Met Lys Gln Arg Ser Ser Trp 
                565                 570                 575     


Asp Ser Gln Gln Asp Gly Ser Gly Tyr Glu Ser Asp Gly Ala Leu Pro 
            580                 585                 590         


Leu Pro Met Pro Gly Pro Val Val Arg Ala Phe Ser Glu Asp Glu Ala 
        595                 600                 605             


Leu Ala Gln Gln Glu Asn Arg His Trp Arg Arg Gly Thr Phe Glu Lys 
    610                 615                 620                 


Leu Gly Phe Pro Gln Ile Leu Leu Glu Lys Ser Val Ser Val Gln Thr 
625                 630                 635                 640 


Asn Leu Ala Ser Pro Glu Pro Tyr Leu His Pro Ser Gln Ser Glu Asp 
                645                 650                 655     


Leu Ala Ala Cys Ala Gln Phe Glu Ser Ser Arg Gln Ser Arg Ser Gly 
            660                 665                 670         


Val Pro Ser Ser Ser Cys Val Phe Pro Thr Phe Thr Leu Arg Lys Pro 
        675                 680                 685             


Ser Ser Glu Thr Asp Ile Glu Asn Trp Ala Ser Lys His Phe Asn Lys 
    690                 695                 700                 


His Thr Gln Gly Leu Phe Arg Arg Lys Val Ser Ile Ala Asn Met Leu 
705                 710                 715                 720 


Ala Trp Ser Ser Glu Ser Ile Lys Lys Pro Met Ile Val Thr Ser Asp 
                725                 730                 735     


Arg His Val Lys Lys Glu Ala Cys Glu Leu Phe Lys Leu Ile Gln Met 
            740                 745                 750         


Tyr Met Gly Asp Arg Arg Ala Lys Ala Asp Pro Leu His Val Ala Leu 
        755                 760                 765             


Glu Val Ala Thr Lys Gly Trp Ser Val Gln Gly Leu Arg Asp Glu Leu 
    770                 775                 780                 


Tyr Ile Gln Leu Cys Arg Gln Thr Thr Glu Asn Phe Arg Leu Glu Ser 
785                 790                 795                 800 


Leu Ala Arg Gly Trp Glu Leu Met Ala Ile Cys Leu Ala Phe Phe Pro 
                805                 810                 815     


Pro Thr Pro Lys Phe His Ser Tyr Leu Glu Gly Tyr Ile Tyr Arg His 
            820                 825                 830         


Met Asp Pro Val Asn Asp Thr Lys Gly Val Ala Ile Ser Thr Tyr Ala 
        835                 840                 845             


Lys Tyr Cys Tyr His Lys Leu Gln Lys Ala Ala Leu Thr Gly Ala Lys 
    850                 855                 860                 


Lys Gly Leu Lys Lys Pro Asn Val Glu Glu Ile Arg His Ala Lys Asn 
865                 870                 875                 880 


Ala Val Phe Ser Pro Ser Met Phe Gly Ser Ala Leu Gln Glu Val Met 
                885                 890                 895     


Gly Met Gln Arg Glu Arg Tyr Pro Glu Arg Gln Leu Pro Trp Val Gln 
            900                 905                 910         


Thr Arg Leu Ser Glu Glu Val Leu Ala Leu Asn Gly Asp Gln Thr Glu 
        915                 920                 925             


Gly Ile Phe Arg Val Pro Gly Asp Ile Asp Glu Val Asn Ala Leu Lys 
    930                 935                 940                 


Leu Gln Val Asp Gln Trp Lys Val Pro Thr Gly Leu Glu Asp Pro His 
945                 950                 955                 960 


Val Pro Ala Ser Leu Leu Lys Leu Trp Tyr Arg Glu Leu Glu Glu Pro 
                965                 970                 975     


Leu Ile Pro His Glu Phe Tyr Glu Gln Cys Ile Ala His Tyr Asp Ser 
            980                 985                 990         


Pro Glu Ala Ala Val Ala Val Val  His Ala Leu Pro Arg  Ile Asn Arg 
        995                 1000                 1005             


Met Val  Leu Cys Tyr Leu Ile  Arg Phe Leu Gln Val  Phe Val Gln 
    1010                 1015                 1020             


Pro Ala  Asn Val Ala Val Thr  Lys Met Asp Val Ser  Asn Leu Ala 
    1025                 1030                 1035             


Met Val  Met Ala Pro Asn Cys  Leu Arg Cys Gln Ser  Asp Asp Pro 
    1040                 1045                 1050             


Arg Val  Ile Phe Glu Asn Thr  Arg Lys Glu Met Ser  Phe Leu Arg 
    1055                 1060                 1065             


Val Leu  Ile Gln His Leu Asp  Thr Ser Phe Met Glu  Gly Val Leu 
    1070                 1075                 1080             


<210> 5043
<211> 141
<212> PRT
<213> Homo sapiens

<400> 5043
Met Gly Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu 
1               5                   10                  15      


Cys Asn Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg 
            20                  25                  30          


Val Val Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu 
        35                  40                  45              


Thr Gln Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys 
    50                  55                  60                  


Glu Ala Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly 
65                  70                  75                  80  


Ser Phe Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe 
                85                  90                  95      


Met Pro Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro 
            100                 105                 110         


Ala Ala Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser 
        115                 120                 125             


Glu Ile Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys 
    130                 135                 140     


<210> 5044
<211> 566
<212> PRT
<213> Homo sapiens

<400> 5044
Met Asp Ile Gln Leu Asp Pro Ala Arg Asp Asp Leu Pro Leu Met Ala 
1               5                   10                  15      


Asn Thr Ser His Ile Leu Val Lys His Tyr Val Leu Asp Leu Asp Val 
            20                  25                  30          


Asp Phe Glu Ser Gln Val Ile Glu Gly Thr Ile Val Leu Phe Leu Glu 
        35                  40                  45              


Asp Gly Asn Arg Phe Lys Lys Gln Asn Ser Ser Ile Glu Glu Ala Cys 
    50                  55                  60                  


Gln Ser Glu Ser Asn Lys Ala Cys Lys Phe Gly Met Pro Glu Pro Cys 
65                  70                  75                  80  


His Ile Pro Val Thr Asn Ala Arg Thr Phe Ser Ser Glu Met Glu Tyr 
                85                  90                  95      


Asn Asp Phe Ala Ile Cys Ser Lys Gly Glu Lys Asp Thr Ser Asp Lys 
            100                 105                 110         


Asp Gly Asn His Asp Asn Gln Glu His Ala Ser Gly Ile Ser Ser Ser 
        115                 120                 125             


Lys Tyr Cys Cys Asp Thr Gly Asn His Gly Ser Glu Asp Phe Leu Leu 
    130                 135                 140                 


Val Leu Asp Cys Cys Asp Leu Ser Val Leu Lys Val Glu Glu Val Asp 
145                 150                 155                 160 


Val Ala Ala Val Pro Gly Leu Glu Lys Phe Thr Arg Ser Pro Glu Leu 
                165                 170                 175     


Thr Val Val Ser Glu Glu Phe Arg Asn Gln Ile Val Arg Glu Leu Val 
            180                 185                 190         


Thr Leu Pro Ala Asn Arg Trp Arg Glu Gln Leu Asp Tyr Tyr Ala Arg 
        195                 200                 205             


Cys Ser Gln Ala Pro Gly Cys Gly Glu Leu Leu Phe Asp Thr Asp Thr 
    210                 215                 220                 


Trp Ser Leu Gln Ile Arg Lys Thr Gly Ala Gln Thr Ala Thr Asp Phe 
225                 230                 235                 240 


Pro His Ala Ile Arg Ile Trp Tyr Lys Thr Lys Pro Glu Gly Arg Ser 
                245                 250                 255     


Val Thr Trp Thr Ser Asp Gln Ser Gly Arg Pro Cys Val Tyr Thr Val 
            260                 265                 270         


Gly Ser Pro Ile Asn Asn Arg Ala Leu Phe Pro Cys Gln Glu Pro Pro 
        275                 280                 285             


Val Ala Met Ser Thr Trp Gln Ala Thr Val Arg Ala Ala Ala Ser Phe 
    290                 295                 300                 


Val Val Leu Met Ser Gly Glu Asn Ser Ala Lys Pro Thr Gln Leu Trp 
305                 310                 315                 320 


Glu Glu Cys Ser Ser Trp Tyr Tyr Tyr Val Thr Met Pro Met Pro Ala 
                325                 330                 335     


Ser Thr Phe Thr Ile Ala Val Gly Cys Trp Thr Glu Met Lys Met Glu 
            340                 345                 350         


Thr Trp Ser Ser Asn Asp Leu Ala Thr Glu Arg Pro Phe Ser Pro Ser 
        355                 360                 365             


Glu Ala Asn Phe Arg His Val Gly Val Cys Ser His Met Glu Tyr Pro 
    370                 375                 380                 


Cys Arg Phe Gln Asn Ala Ser Ala Thr Thr Gln Glu Ile Ile Pro His 
385                 390                 395                 400 


Arg Val Phe Ala Pro Val Cys Leu Thr Gly Ala Cys Gln Glu Thr Leu 
                405                 410                 415     


Leu Arg Leu Ile Pro Pro Cys Leu Ser Ala Ala His Ser Val Leu Gly 
            420                 425                 430         


Ala His Pro Phe Ser Arg Leu Asp Val Leu Ile Val Pro Ala Asn Phe 
        435                 440                 445             


Pro Ser Leu Gly Met Ala Ser Pro His Ile Met Phe Leu Ser Gln Ser 
    450                 455                 460                 


Ile Leu Thr Gly Gly Asn His Leu Cys Gly Thr Arg Leu Cys His Glu 
465                 470                 475                 480 


Ile Ala His Ala Trp Phe Gly Leu Ala Ile Gly Ala Arg Asp Trp Thr 
                485                 490                 495     


Glu Glu Trp Leu Ser Glu Gly Phe Ala Thr His Leu Glu Asp Val Phe 
            500                 505                 510         


Trp Ala Thr Ala Gln Gln Leu Ala Pro Tyr Glu Ala Arg Glu Gln Gln 
        515                 520                 525             


Glu Leu Arg Ala Cys Leu Arg Trp Arg Arg Leu Gln Asp Glu Met Gln 
    530                 535                 540                 


Cys Ser Pro Glu Glu Met Gln Val Leu Arg Phe Pro His Val Gly Gly 
545                 550                 555                 560 


Cys Ser Gly Ser Phe Ser 
                565     


<210> 5045
<211> 421
<212> PRT
<213> Homo sapiens

<400> 5045
Met Pro Phe Leu His Gly Phe Arg Arg Ile Ile Phe Glu Tyr Gln Pro 
1               5                   10                  15      


Leu Val Asp Ala Ile Leu Gly Ser Leu Gly Ile Gln Asp Pro Glu Arg 
            20                  25                  30          


Gln Glu Ser Leu Asp Arg Pro Ser Tyr Val Ala Ser Glu Glu Ser Arg 
        35                  40                  45              


Ile Leu Val Leu Thr Glu Leu Leu Glu Arg Lys Ala His Ser Pro Phe 
    50                  55                  60                  


Tyr Gln Glu Gly Val Ser Asn Ala Leu Leu Lys Met Ala Glu Leu Gly 
65                  70                  75                  80  


Leu Thr Arg Ala Ala Asp Val Leu Leu Arg His Gly Ala Asn Leu Asn 
                85                  90                  95      


Phe Glu Asp Pro Val Thr Tyr Tyr Thr Ala Leu His Ile Ala Val Leu 
            100                 105                 110         


Arg Asn Gln Pro Asp Met Val Glu Leu Leu Val His His Gly Ala Asp 
        115                 120                 125             


Val Asn Arg Arg Asp Arg Ile His Glu Ser Ser Pro Leu Asp Leu Ala 
    130                 135                 140                 


Ser Glu Glu Pro Glu Arg Leu Pro Cys Leu Gln Arg Leu Leu Asp Leu 
145                 150                 155                 160 


Gly Ala Asp Val Asn Ala Ala Asp Lys His Gly Lys Thr Ala Leu Leu 
                165                 170                 175     


His Ala Leu Ala Ser Ser Asp Gly Val Gln Ile His Asn Thr Glu Asn 
            180                 185                 190         


Ile Arg Leu Leu Leu Glu Gly Gly Ala Asp Val Lys Ala Thr Thr Lys 
        195                 200                 205             


Asp Gly Asp Thr Val Phe Thr Cys Ile Ile Phe Leu Leu Gly Glu Thr 
    210                 215                 220                 


Val Gly Gly Asp Lys Glu Glu Ala Gln Met Ile Asn Arg Phe Cys Phe 
225                 230                 235                 240 


Gln Val Thr Arg Leu Leu Leu Ala His Gly Ala Asp Pro Ser Glu Cys 
                245                 250                 255     


Pro Ala His Glu Ser Leu Thr His Ile Cys Leu Lys Ser Phe Lys Leu 
            260                 265                 270         


His Phe Pro Leu Leu Arg Phe Leu Leu Glu Ser Gly Ala Ala Tyr Asn 
        275                 280                 285             


Cys Ser Leu His Gly Ala Ser Cys Trp Ser Gly Phe His Ile Ile Phe 
    290                 295                 300                 


Glu Arg Leu Cys Ser His Pro Gly Cys Thr Glu Asp Glu Ser His Ala 
305                 310                 315                 320 


Asp Leu Leu Arg Lys Ala Glu Thr Val Leu Asp Leu Met Val Thr Asn 
                325                 330                 335     


Ser Gln Lys Leu Gln Leu Pro Glu Asn Phe Asp Ile His Pro Val Gly 
            340                 345                 350         


Ser Leu Ala Glu Lys Ile Gln Ala Leu His Phe Ser Leu Arg Gln Leu 
        355                 360                 365             


Glu Ser Tyr Pro Pro Pro Leu Lys His Leu Cys Arg Val Ala Ile Arg 
    370                 375                 380                 


Leu Tyr Leu Gln Pro Trp Pro Val Asp Val Lys Val Lys Ala Leu Pro 
385                 390                 395                 400 


Leu Pro Asp Arg Leu Lys Trp Tyr Leu Leu Ser Glu His Ser Gly Ser 
                405                 410                 415     


Val Glu Asp Asp Ile 
            420     


<210> 5046
<211> 197
<212> PRT
<213> Homo sapiens

<400> 5046
Met Pro Phe Leu His Gly Phe Arg Arg Ile Ile Phe Glu Tyr Gln Pro 
1               5                   10                  15      


Leu Val Asp Ala Ile Leu Gly Ser Leu Gly Ile Gln Asp Pro Glu Arg 
            20                  25                  30          


Gln Glu Ser Leu Asp Arg Pro Ser Tyr Val Ala Ser Glu Glu Ser Arg 
        35                  40                  45              


Ile Leu Val Leu Thr Glu Leu Leu Glu Arg Lys Ala His Ser Pro Phe 
    50                  55                  60                  


Tyr Gln Glu Gly Val Ser Asn Ala Leu Leu Lys Met Ala Glu Leu Gly 
65                  70                  75                  80  


Leu Thr Arg Ala Ala Asp Val Leu Leu Arg His Gly Ala Asn Leu Asn 
                85                  90                  95      


Phe Glu Asp Pro Val Thr Tyr Tyr Thr Ala Leu His Ile Ala Val Leu 
            100                 105                 110         


Arg Asn Gln Pro Asp Met Val Glu Leu Leu Val His His Gly Ala Asp 
        115                 120                 125             


Val Asn Arg Arg Asp Arg Glu Lys Leu Leu Cys Ser Met Leu Trp Pro 
    130                 135                 140                 


Ala Ala Thr Gly Cys Arg Ser Thr Ile Leu Arg Thr Phe Val Ser Tyr 
145                 150                 155                 160 


Trp Lys Glu Gly Gln Thr Ser Arg Pro Pro Pro Lys Met Gly Thr Gln 
                165                 170                 175     


Cys Ser Pro Ala Ser Ser Ser Cys Leu Val Arg Pro Trp Glu Gly Thr 
            180                 185                 190         


Lys Arg Arg Pro Arg 
        195         


<210> 5047
<211> 227
<212> PRT
<213> Homo sapiens

<400> 5047
Met Ser Asp Ile Asn Leu Asp Trp Val Asp Arg Arg Gln Leu Gln Arg 
1               5                   10                  15      


Leu Glu Glu Met Leu Ile Val Val Asp Glu Asn Asp Lys Val Ile Gly 
            20                  25                  30          


Ala Asp Thr Lys Arg Asn Cys His Leu Asn Glu Asn Ile Glu Lys Gly 
        35                  40                  45              


Leu Leu His Arg Ala Phe Ser Val Val Leu Phe Asn Thr Lys Asn Arg 
    50                  55                  60                  


Ile Leu Ile Gln Gln Arg Ser Asp Thr Lys Val Thr Phe Pro Gly Tyr 
65                  70                  75                  80  


Phe Thr Asp Ser Cys Ser Ser His Pro Leu Tyr Asn Pro Ala Glu Leu 
                85                  90                  95      


Glu Glu Lys Asp Ala Ile Gly Val Arg Arg Ala Ala Gln Arg Arg Leu 
            100                 105                 110         


Gln Ala Glu Leu Gly Ile Pro Gly Glu Gln Ile Ser Pro Glu Asp Ile 
        115                 120                 125             


Val Phe Met Thr Ile Tyr His His Lys Ala Lys Ser Asp Arg Ile Trp 
    130                 135                 140                 


Gly Glu His Glu Ile Cys Tyr Leu Leu Leu Val Arg Lys Asn Val Thr 
145                 150                 155                 160 


Leu Asn Pro Asp Pro Ser Glu Thr Lys Ser Ile Leu Tyr Leu Ser Gln 
                165                 170                 175     


Glu Glu Leu Trp Glu Leu Leu Glu Arg Glu Ala Arg Gly Glu Val Lys 
            180                 185                 190         


Val Thr Pro Trp Leu Arg Thr Ile Ala Glu Arg Phe Leu Tyr Arg Trp 
        195                 200                 205             


Trp Pro His Leu Asp Asp Val Thr Pro Phe Val Glu Leu His Lys Ile 
    210                 215                 220                 


His Arg Val 
225         


<210> 5048
<211> 287
<212> PRT
<213> Homo sapiens

<400> 5048
Met Glu Val Met Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg 
1               5                   10                  15      


Arg Ala Asp Arg Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser 
            20                  25                  30          


Cys His Lys Lys Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr 
        35                  40                  45              


Gln Ser Glu Gln Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His 
    50                  55                  60                  


Met Lys Gln Leu Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg 
65                  70                  75                  80  


Glu Glu Arg Leu Lys Ala Gln Gln Asn Thr Asp Lys Asp Ala Ala Ala 
                85                  90                  95      


His Leu Gln Thr Ser His Lys Pro Ser Ala Glu Asp Ala Glu Gly Gln 
            100                 105                 110         


Ser Pro Leu Ser Gln Lys Tyr Ser Pro Ser Thr Glu Lys Cys Leu Pro 
        115                 120                 125             


Glu Ile Gln Gly Ile Phe Asp Arg Asp Pro Asp Thr Leu Leu Tyr Leu 
    130                 135                 140                 


Leu Gln Gln Lys Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala 
145                 150                 155                 160 


Pro Lys Asp Asp Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala 
                165                 170                 175     


Asp Leu Lys Arg His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu 
            180                 185                 190         


Arg Lys Glu Asn Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys 
        195                 200                 205             


Gly Pro Ile Glu Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr 
    210                 215                 220                 


Ser Glu Leu Trp Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser 
225                 230                 235                 240 


Ser Thr Trp Gln Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile 
                245                 250                 255     


Pro Ile Pro Asn Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro 
            260                 265                 270         


Leu Met Glu Leu Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn 
        275                 280                 285         


<210> 5049
<211> 947
<212> PRT
<213> Homo sapiens

<400> 5049
Met Cys Val Asp Ser Leu Val Arg Ile Cys Ser Gly Leu Ser Tyr Gly 
1               5                   10                  15      


Arg Ile Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val 
            20                  25                  30          


Ala Cys Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val 
        35                  40                  45              


Phe Cys Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp 
    50                  55                  60                  


Cys Lys Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile 
65                  70                  75                  80  


Pro Phe Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr 
                85                  90                  95      


Leu Ser Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu 
            100                 105                 110         


Gly Leu Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser 
        115                 120                 125             


Leu Arg Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr 
    130                 135                 140                 


Ala Ala Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly 
145                 150                 155                 160 


Tyr Gly Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg 
                165                 170                 175     


Lys Val Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly 
            180                 185                 190         


Arg Gln His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser 
        195                 200                 205             


Phe Gly Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn 
    210                 215                 220                 


Arg Lys Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly 
225                 230                 235                 240 


Gln Cys Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg 
                245                 250                 255     


Ile Phe Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln 
            260                 265                 270         


Asn Cys Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln 
        275                 280                 285             


Ile Trp Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro 
    290                 295                 300                 


Ser Gly Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe 
305                 310                 315                 320 


Ser Ser Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp 
                325                 330                 335     


Asp His Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala 
            340                 345                 350         


Ala Arg Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile 
        355                 360                 365             


Ser Gln Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu 
    370                 375                 380                 


Thr Ser Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu 
385                 390                 395                 400 


Pro Glu Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala 
                405                 410                 415     


Ile Pro Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys 
            420                 425                 430         


Val Leu Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys 
        435                 440                 445             


Ile Val Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr 
    450                 455                 460                 


Lys Ile Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu 
465                 470                 475                 480 


His Thr Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys 
                485                 490                 495     


Met Gly Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln 
            500                 505                 510         


Glu Leu Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln 
        515                 520                 525             


Ala Tyr Gly Met Asp Val Asn His Gly Leu Thr Glu Leu Ala Asp Ile 
    530                 535                 540                 


Pro Val Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys 
545                 550                 555                 560 


Thr Thr Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile 
                565                 570                 575     


Asp Gln Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile 
            580                 585                 590         


Glu Ser Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile 
        595                 600                 605             


Val Gly Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr 
    610                 615                 620                 


Lys Lys Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala 
625                 630                 635                 640 


Gly Gly Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu 
                645                 650                 655     


Asp Pro Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile 
            660                 665                 670         


Trp Phe Ser Asp Lys Thr Phe Glu Asp Ser Asp Leu Phe His Leu Ile 
        675                 680                 685             


Gly Val Ile Cys Gly Leu Ala Ile Tyr Asn Cys Thr Ile Val Asp Leu 
    690                 695                 700                 


His Phe Pro Leu Ala Leu Tyr Lys Lys Leu Leu Lys Lys Lys Pro Ser 
705                 710                 715                 720 


Leu Asp Asp Leu Lys Glu Leu Met Pro Asp Val Gly Arg Ser Met Gln 
                725                 730                 735     


Gln Leu Leu Asp Tyr Pro Glu Asp Asp Ile Glu Glu Thr Phe Cys Leu 
            740                 745                 750         


Asn Phe Thr Ile Thr Val Glu Asn Phe Gly Ala Thr Glu Val Lys Glu 
        755                 760                 765             


Leu Val Leu Asn Gly Ala Asp Thr Ala Val Asn Lys Gln Asn Arg Gln 
    770                 775                 780                 


Glu Phe Val Asp Ala Tyr Val Asp Tyr Ile Phe Asn Lys Ser Val Ala 
785                 790                 795                 800 


Ser Leu Phe Asp Ala Phe His Ala Gly Phe His Lys Val Cys Gly Gly 
                805                 810                 815     


Lys Val Leu Leu Leu Phe Gln Pro Asn Glu Leu Gln Ala Met Val Ile 
            820                 825                 830         


Gly Asn Thr Asn Tyr Asp Trp Lys Glu Leu Glu Lys Asn Thr Glu Tyr 
        835                 840                 845             


Lys Gly Glu Tyr Trp Ala Glu His Pro Thr Ile Lys Ile Phe Trp Glu 
    850                 855                 860                 


Val Phe His Glu Leu Pro Leu Glu Lys Lys Lys Gln Phe Leu Leu Phe 
865                 870                 875                 880 


Leu Thr Gly Ser Asp Arg Ile Pro Ile Leu Gly Met Lys Ser Leu Lys 
                885                 890                 895     


Leu Val Ile Gln Ser Thr Gly Gly Gly Glu Glu Tyr Leu Pro Val Ser 
            900                 905                 910         


His Thr Cys Phe Asn Leu Leu Asp Leu Pro Lys Tyr Thr Glu Lys Glu 
        915                 920                 925             


Thr Leu Arg Ser Lys Leu Ile Gln Ala Ile Asp His Asn Glu Gly Phe 
    930                 935                 940                 


Ser Leu Ile 
945         


<210> 5050
<211> 846
<212> PRT
<213> Homo sapiens

<400> 5050
Met Pro Ala Phe Leu Gly Leu Lys Cys Leu Gly Lys Leu Cys Ser Ser 
1               5                   10                  15      


Glu Lys Ser Lys Val Thr Ser Ser Glu Arg Thr Ser Ala Arg Gly Ser 
            20                  25                  30          


Asn Arg Lys Arg Leu Ile Val Glu Asp Arg Arg Val Ser Gly Thr Ser 
        35                  40                  45              


Phe Thr Ala His Arg Arg Ala Thr Ile Thr His Leu Leu Tyr Leu Cys 
    50                  55                  60                  


Pro Lys Asp Tyr Cys Pro Arg Gly Arg Val Cys Asn Ser Val Asp Pro 
65                  70                  75                  80  


Phe Val Ala His Pro Gln Asp Pro His His Pro Ser Glu Lys Pro Val 
                85                  90                  95      


Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly Glu Val Leu Arg 
            100                 105                 110         


Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr Cys Lys Val Cys 
        115                 120                 125             


Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys Asn Gly Glu Tyr 
    130                 135                 140                 


Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr Arg Cys His Gly 
145                 150                 155                 160 


Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala Leu Gly Lys Thr 
                165                 170                 175     


Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys Arg Pro Phe Pro 
            180                 185                 190         


Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys Leu Cys Gln Leu 
        195                 200                 205             


Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr Thr Phe Ser Ser 
    210                 215                 220                 


Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly Gln Ala Leu Leu 
225                 230                 235                 240 


Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys Cys Lys Ser Cys 
                245                 250                 255     


Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp Gly Ala Pro Tyr 
            260                 265                 270         


Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys Cys Glu Ala Cys 
        275                 280                 285             


His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly Asp Lys His Tyr 
    290                 295                 300                 


His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln Met Phe Thr Glu 
305                 310                 315                 320 


Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp His Pro Asp Cys 
                325                 330                 335     


Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu Pro Asn Ile Arg 
            340                 345                 350         


Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu Ile Arg Arg Thr 
        355                 360                 365             


Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser Ser Glu Ser Ile 
    370                 375                 380                 


Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro Gly His Thr Ile 
385                 390                 395                 400 


Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys Asp Leu Ala Ala 
                405                 410                 415     


Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg Pro Asp Leu Ile 
            420                 425                 430         


Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp Lys Gln Glu Arg 
        435                 440                 445             


Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro Thr Pro Ser Ala 
    450                 455                 460                 


Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His Arg Ser Thr Ser 
465                 470                 475                 480 


Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His Ser Tyr Thr Pro 
                485                 490                 495     


Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro Glu Leu Leu Ser 
            500                 505                 510         


Pro Gly Val Gln Arg Leu Ser Tyr Leu Arg Thr Ser Ser Leu Ser Pro 
        515                 520                 525             


Thr His Ser Asp Ser Arg Pro Asn Pro Pro Phe Arg His His Phe Ile 
    530                 535                 540                 


Pro His Ile Lys Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
545                 550                 555                 560 


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
                565                 570                 575     


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
            580                 585                 590         


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
        595                 600                 605             


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
    610                 615                 620                 


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
625                 630                 635                 640 


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
                645                 650                 655     


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
            660                 665                 670         


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
        675                 680                 685             


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
    690                 695                 700                 


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
705                 710                 715                 720 


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
                725                 730                 735     


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
            740                 745                 750         


Val Arg Asp Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
        755                 760                 765             


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
    770                 775                 780                 


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
785                 790                 795                 800 


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
                805                 810                 815     


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
            820                 825                 830         


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
        835                 840                 845     


<210> 5051
<211> 197
<212> PRT
<213> Homo sapiens

<400> 5051
Met Phe Gly Cys Leu Val Ala Gly Arg Leu Val Gln Thr Ala Ala Gln 
1               5                   10                  15      


Gln Val Ala Glu Asp Lys Phe Val Phe Asp Leu Pro Asp Tyr Glu Ser 
            20                  25                  30          


Ile Asn His Val Val Val Phe Met Leu Gly Thr Ile Pro Phe Pro Glu 
        35                  40                  45              


Gly Met Gly Gly Ser Val Tyr Phe Ser Tyr Pro Asp Ser Asn Gly Met 
    50                  55                  60                  


Pro Val Trp Gln Leu Leu Gly Phe Val Thr Asn Gly Lys Pro Ser Ala 
65                  70                  75                  80  


Ile Phe Lys Ile Ser Gly Leu Lys Ser Gly Glu Gly Ser Gln His Pro 
                85                  90                  95      


Phe Gly Ala Met Asn Ile Val Arg Thr Pro Ser Val Ala Gln Ile Gly 
            100                 105                 110         


Ile Ser Val Glu Leu Leu Asp Ser Met Ala Gln Gln Thr Pro Val Gly 
        115                 120                 125             


Asn Ala Ala Val Ser Ser Val Asp Ser Phe Thr Gln Phe Thr Gln Lys 
    130                 135                 140                 


Met Leu Asp Asn Phe Tyr Asn Phe Ala Ser Ser Phe Ala Val Ser Gln 
145                 150                 155                 160 


Ala Gln Met Thr Pro Ser Pro Ser Glu Met Phe Ile Pro Ala Asn Val 
                165                 170                 175     


Val Leu Lys Trp Tyr Glu Asn Phe Gln Arg Arg Leu Ala Gln Asn Pro 
            180                 185                 190         


Leu Phe Trp Lys Thr 
        195         


<210> 5052
<211> 309
<212> PRT
<213> Homo sapiens

<400> 5052
Met Val Phe Pro Ala Lys Arg Phe Cys Leu Val Pro Ser Met Glu Gly 
1               5                   10                  15      


Val Arg Trp Ala Phe Ser Cys Gly Thr Trp Leu Pro Ser Arg Ala Glu 
            20                  25                  30          


Trp Leu Leu Ala Val Arg Ser Ile Gln Pro Glu Glu Lys Glu Arg Ile 
        35                  40                  45              


Gly Gln Phe Val Phe Ala Arg Asp Ala Lys Ala Ala Met Ala Gly Arg 
    50                  55                  60                  


Leu Met Ile Arg Lys Leu Val Ala Glu Lys Leu Asn Ile Pro Trp Asn 
65                  70                  75                  80  


His Ile Arg Leu Gln Arg Thr Ala Lys Gly Lys Pro Val Leu Ala Lys 
                85                  90                  95      


Asp Ser Ser Asn Pro Tyr Pro Asn Phe Asn Phe Asn Ile Ser His Gln 
            100                 105                 110         


Gly Asp Tyr Ala Val Leu Ala Ala Glu Pro Glu Leu Gln Val Gly Ile 
        115                 120                 125             


Asp Ile Met Lys Thr Ser Phe Pro Gly Arg Gly Ser Ile Pro Glu Phe 
    130                 135                 140                 


Phe His Ile Met Lys Arg Lys Phe Thr Asn Lys Glu Trp Glu Thr Ile 
145                 150                 155                 160 


Arg Ser Phe Lys Asp Glu Trp Thr Gln Leu Asp Met Phe Tyr Arg Asn 
                165                 170                 175     


Trp Ala Leu Lys Glu Ser Phe Ile Lys Ala Ile Gly Val Gly Leu Gly 
            180                 185                 190         


Phe Glu Leu Gln Arg Leu Glu Phe Asp Leu Ser Pro Leu Asn Leu Asp 
        195                 200                 205             


Ile Gly Gln Val Tyr Lys Glu Thr Arg Leu Phe Leu Asp Gly Glu Glu 
    210                 215                 220                 


Glu Lys Glu Trp Ala Phe Glu Glu Ser Lys Ile Asp Glu His His Phe 
225                 230                 235                 240 


Val Ala Val Ala Leu Arg Lys Pro Asp Gly Ser Arg His Gln Asp Val 
                245                 250                 255     


Pro Ser Gln Asp Asp Ser Lys Pro Thr Gln Arg Gln Phe Thr Ile Leu 
            260                 265                 270         


Asn Phe Asn Asp Leu Met Ser Ser Ala Val Pro Met Thr Pro Glu Asp 
        275                 280                 285             


Pro Ser Phe Trp Asp Cys Phe Cys Phe Thr Glu Glu Ile Pro Ile Arg 
    290                 295                 300                 


Asn Gly Thr Lys Ser 
305                 


<210> 5053
<211> 532
<212> PRT
<213> Homo sapiens

<400> 5053
Met Gln Ser Cys Glu Ser Ser Gly Asp Ser Ala Asp Asp Pro Leu Ser 
1               5                   10                  15      


Arg Gly Leu Arg Arg Arg Gly Gln Pro Arg Val Val Val Ile Gly Ala 
            20                  25                  30          


Gly Leu Ala Gly Leu Ala Ala Ala Lys Ala Leu Leu Glu Gln Gly Phe 
        35                  40                  45              


Thr Asp Val Thr Val Leu Glu Ala Ser Ser His Ile Gly Gly Arg Val 
    50                  55                  60                  


Gln Ser Val Lys Leu Gly His Ala Thr Phe Glu Leu Gly Ala Thr Trp 
65                  70                  75                  80  


Ile His Gly Ser His Gly Asn Pro Ile Tyr His Leu Ala Glu Ala Asn 
                85                  90                  95      


Gly Leu Leu Glu Glu Thr Thr Asp Gly Glu Arg Ser Val Gly Arg Ile 
            100                 105                 110         


Ser Leu Tyr Ser Lys Asn Gly Val Ala Cys Tyr Leu Thr Asn His Gly 
        115                 120                 125             


Arg Arg Ile Pro Lys Asp Val Val Glu Glu Phe Ser Asp Leu Tyr Asn 
    130                 135                 140                 


Glu Val Tyr Asn Leu Thr Gln Glu Phe Phe Arg His Asp Lys Pro Val 
145                 150                 155                 160 


Asn Ala Glu Ser Gln Asn Ser Val Gly Val Phe Thr Arg Glu Glu Val 
                165                 170                 175     


Arg Asn Arg Ile Arg Asn Asp Pro Asp Asp Pro Glu Ala Thr Lys Arg 
            180                 185                 190         


Leu Lys Leu Ala Met Ile Gln Gln Tyr Leu Lys Val Glu Ser Cys Glu 
        195                 200                 205             


Ser Ser Ser His Ser Met Asp Glu Val Ser Leu Ser Ala Phe Gly Glu 
    210                 215                 220                 


Trp Thr Glu Ile Pro Gly Ala His His Ile Ile Pro Ser Gly Phe Met 
225                 230                 235                 240 


Arg Val Val Glu Leu Leu Ala Glu Gly Ile Pro Ala His Val Ile Gln 
                245                 250                 255     


Leu Gly Lys Pro Val Arg Cys Ile His Trp Asp Gln Ala Ser Ala Arg 
            260                 265                 270         


Pro Arg Gly Pro Glu Ile Glu Pro Arg Gly Val Leu Lys Arg Gln Tyr 
        275                 280                 285             


Thr Ser Phe Phe Arg Pro Gly Leu Pro Thr Glu Lys Val Ala Ala Ile 
    290                 295                 300                 


His Arg Leu Gly Ile Gly Thr Thr Asp Lys Ile Phe Leu Glu Phe Glu 
305                 310                 315                 320 


Glu Pro Phe Trp Gly Pro Glu Cys Asn Ser Leu Gln Phe Val Trp Glu 
                325                 330                 335     


Asp Glu Ala Glu Ser His Thr Leu Thr Tyr Pro Pro Glu Leu Trp Tyr 
            340                 345                 350         


Arg Lys Ile Cys Gly Phe Asp Val Leu Tyr Pro Pro Glu Arg Tyr Gly 
        355                 360                 365             


His Val Leu Ser Gly Trp Ile Cys Gly Glu Glu Ala Leu Val Met Glu 
    370                 375                 380                 


Lys Cys Asp Asp Glu Ala Val Ala Glu Ile Cys Thr Glu Met Leu Arg 
385                 390                 395                 400 


Gln Phe Thr Gly Asn Pro Asn Ile Pro Lys Pro Arg Arg Ile Leu Arg 
                405                 410                 415     


Ser Ala Trp Gly Ser Asn Pro Tyr Phe Arg Gly Ser Tyr Ser Tyr Thr 
            420                 425                 430         


Gln Val Gly Ser Ser Gly Ala Asp Val Glu Lys Leu Ala Lys Pro Leu 
        435                 440                 445             


Pro Tyr Thr Glu Ser Ser Lys Thr Ala His Gly Ser Ser Thr Lys Gln 
    450                 455                 460                 


Gln Pro Gly His Leu Phe Ser Ser Lys Cys Pro Glu Gln Pro Leu Asp 
465                 470                 475                 480 


Ala Asn Arg Gly Ala Val Lys Pro Met Gln Val Leu Phe Ser Gly Glu 
                485                 490                 495     


Ala Thr His Arg Lys Tyr Tyr Ser Thr Thr His Gly Ala Leu Leu Ser 
            500                 505                 510         


Gly Gln Arg Glu Ala Ala Arg Leu Ile Glu Met Tyr Arg Asp Leu Phe 
        515                 520                 525             


Gln Gln Gly Thr 
    530         


<210> 5054
<211> 782
<212> PRT
<213> Homo sapiens

<400> 5054
Met Asp Ser Ser Ile His Leu Ser Ser Leu Ile Ser Arg His Asp Asp 
1               5                   10                  15      


Glu Ala Thr Arg Thr Ser Thr Ser Glu Gly Leu Glu Glu Gly Glu Val 
            20                  25                  30          


Glu Gly Glu Thr Leu Leu Ile Val Glu Ser Glu Asp Gln Ala Ser Val 
        35                  40                  45              


Asp Leu Ser His Asp Gln Ser Gly Asp Ser Leu Asn Ser Asp Glu Gly 
    50                  55                  60                  


Asp Val Ser Trp Met Glu Glu Gln Leu Ser Tyr Phe Cys Asp Lys Cys 
65                  70                  75                  80  


Gln Lys Trp Ile Pro Ala Ser Gln Leu Arg Glu Gln Leu Ser Tyr Leu 
                85                  90                  95      


Lys Gly Asp Asn Phe Phe Arg Phe Thr Cys Ser Asp Cys Ser Ala Asp 
            100                 105                 110         


Gly Lys Glu Gln Tyr Glu Arg Leu Lys Leu Thr Trp Gln Gln Val Val 
        115                 120                 125             


Met Leu Ala Met Tyr Asn Leu Ser Leu Glu Gly Ser Gly Arg Gln Gly 
    130                 135                 140                 


Tyr Phe Arg Trp Lys Glu Asp Ile Cys Ala Phe Ile Glu Lys His Trp 
145                 150                 155                 160 


Thr Phe Leu Leu Gly Asn Arg Lys Lys Thr Ser Thr Trp Trp Ser Thr 
                165                 170                 175     


Val Ala Gly Cys Leu Ser Val Gly Ser Pro Met Tyr Phe Arg Ser Gly 
            180                 185                 190         


Ala Gln Glu Phe Gly Glu Pro Gly Trp Trp Lys Leu Val His Asn Lys 
        195                 200                 205             


Pro Pro Thr Met Lys Pro Glu Gly Glu Lys Leu Ser Ala Ser Thr Leu 
    210                 215                 220                 


Lys Ile Lys Ala Ala Ser Lys Pro Thr Leu Asp Pro Ile Ile Thr Val 
225                 230                 235                 240 


Glu Gly Leu Arg Lys Arg Ala Ser Arg Asn Pro Val Glu Ser Ala Met 
                245                 250                 255     


Glu Leu Lys Glu Lys Arg Ser Arg Thr Gln Glu Ala Lys Asp Ile Arg 
            260                 265                 270         


Arg Ala Gln Lys Glu Ala Ala Gly Phe Leu Asp Arg Ser Thr Ser Ser 
        275                 280                 285             


Thr Pro Val Lys Phe Ile Ser Arg Gly Arg Arg Pro Asp Val Ile Leu 
    290                 295                 300                 


Glu Lys Gly Glu Val Ile Asp Phe Ser Ser Leu Ser Ser Ser Asp Arg 
305                 310                 315                 320 


Thr Pro Leu Thr Ser Pro Ser Pro Ser Pro Ser Leu Asp Phe Ser Ala 
                325                 330                 335     


Pro Gly Thr Pro Ala Ser His Ser Ala Thr Pro Ser Leu Leu Ser Glu 
            340                 345                 350         


Ala Asp Leu Ile Pro Asp Val Met Pro Pro Gln Ala Leu Phe His Asp 
        355                 360                 365             


Asp Asp Glu Met Glu Gly Asp Gly Val Ile Asp Pro Gly Met Glu Tyr 
    370                 375                 380                 


Val Pro Pro Pro Ala Gly Ser Val Ala Ser Gly Pro Val Val Gly Val 
385                 390                 395                 400 


Arg Lys Lys Val Arg Gly Pro Glu Gln Ile Lys Gln Glu Val Glu Ser 
                405                 410                 415     


Glu Glu Glu Lys Pro Asp Arg Met Asp Ile Asp Ser Glu Asp Thr Asp 
            420                 425                 430         


Ser Asn Thr Ser Leu Gln Thr Arg Ala Arg Glu Lys Arg Lys Pro Gln 
        435                 440                 445             


Leu Glu Lys Asp Thr Lys Pro Lys Glu Pro Arg Tyr Thr Pro Val Ser 
    450                 455                 460                 


Ile Tyr Glu Glu Lys Leu Leu Leu Lys Arg Leu Glu Ala Cys Pro Gly 
465                 470                 475                 480 


Ala Val Ala Met Thr Pro Glu Ala Arg Arg Leu Lys Arg Lys Leu Ile 
                485                 490                 495     


Val Arg Gln Ala Lys Arg Asp Arg Gly Leu Pro Leu Phe Asp Leu Asp 
            500                 505                 510         


Gln Val Val Asn Ala Ala Leu Leu Leu Val Asp Gly Ile Tyr Gly Ala 
        515                 520                 525             


Lys Glu Gly Gly Ile Ser Arg Leu Pro Ala Gly Gln Ala Thr Tyr Arg 
    530                 535                 540                 


Thr Thr Cys Gln Asp Phe Arg Ile Leu Asp Arg Tyr Gln Thr Ser Leu 
545                 550                 555                 560 


Pro Ser Arg Lys Gly Phe Arg His Gln Thr Thr Lys Phe Leu Tyr Arg 
                565                 570                 575     


Leu Val Gly Ser Glu Asp Met Ala Val Asp Gln Ser Ile Val Ser Pro 
            580                 585                 590         


Tyr Thr Ser Arg Ile Leu Lys Pro Tyr Ile Arg Arg Asp Tyr Glu Thr 
        595                 600                 605             


Lys Pro Pro Lys Leu Gln Leu Leu Ser Gln Ile Arg Ser His Leu His 
    610                 615                 620                 


Arg Ser Asp Pro His Trp Thr Pro Glu Pro Asp Ala Pro Leu Asp Tyr 
625                 630                 635                 640 


Cys Tyr Val Arg Pro Asn His Ile Pro Thr Ile Asn Ser Met Cys Gln 
                645                 650                 655     


Glu Phe Phe Trp Pro Gly Ile Asp Leu Ser Glu Cys Leu Gln Tyr Pro 
            660                 665                 670         


Asp Phe Ser Val Val Val Leu Tyr Lys Lys Val Ile Ile Ala Phe Gly 
        675                 680                 685             


Phe Met Val Pro Asp Val Lys Tyr Asn Glu Ala Tyr Ile Ser Phe Leu 
    690                 695                 700                 


Phe Val His Pro Glu Trp Arg Arg Ala Gly Ile Ala Thr Phe Met Ile 
705                 710                 715                 720 


Tyr His Leu Ile Gln Thr Cys Met Gly Lys Asp Val Thr Leu His Val 
                725                 730                 735     


Ser Ala Ser Asn Pro Ala Met Leu Leu Tyr Gln Lys Phe Gly Phe Lys 
            740                 745                 750         


Thr Glu Glu Tyr Val Leu Asp Phe Tyr Asp Lys Tyr Tyr Pro Leu Glu 
        755                 760                 765             


Ser Thr Glu Cys Lys His Ala Phe Phe Leu Arg Leu Arg Arg 
    770                 775                 780         


<210> 5055
<211> 914
<212> PRT
<213> Homo sapiens

<400> 5055
Met Gly Thr Thr Ala Pro Gly Pro Ile His Leu Leu Glu Leu Cys Asp 
1               5                   10                  15      


Gln Lys Leu Met Glu Phe Leu Cys Asn Met Asp Asn Lys Asp Leu Val 
            20                  25                  30          


Trp Leu Glu Glu Ile Gln Glu Glu Ala Glu Arg Met Phe Thr Arg Glu 
        35                  40                  45              


Phe Ser Lys Glu Pro Glu Leu Met Pro Lys Thr Pro Ser Gln Lys Asn 
    50                  55                  60                  


Arg Arg Lys Lys Arg Arg Ile Ser Tyr Val Gln Asp Glu Asn Arg Asp 
65                  70                  75                  80  


Pro Ile Arg Arg Arg Leu Ser Arg Arg Lys Ser Arg Ser Ser Gln Leu 
                85                  90                  95      


Ser Ser Arg Arg Leu Arg Ser Lys Asp Ser Val Glu Lys Leu Ala Thr 
            100                 105                 110         


Val Val Gly Glu Asn Gly Ser Val Leu Arg Arg Val Thr Arg Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Thr Met Ala Leu Ala Ala Pro Ser Ser Pro 
    130                 135                 140                 


Thr Pro Glu Ser Pro Thr Met Leu Thr Lys Lys Pro Glu Asp Asn His 
145                 150                 155                 160 


Thr Gln Cys Gln Leu Val Pro Val Val Glu Ile Gly Ile Ser Glu Arg 
                165                 170                 175     


Gln Asn Ala Glu Gln His Val Thr Gln Leu Met Ser Thr Glu Pro Leu 
            180                 185                 190         


Pro Arg Thr Leu Ser Pro Thr Pro Ala Ser Ala Thr Ala Pro Thr Ser 
        195                 200                 205             


Gln Gly Ile Pro Thr Ser Asp Glu Glu Ser Thr Pro Lys Lys Ser Lys 
    210                 215                 220                 


Ala Arg Ile Leu Glu Ser Ile Thr Val Ser Ser Leu Met Ala Thr Pro 
225                 230                 235                 240 


Gln Asp Pro Lys Gly Gln Gly Val Gly Thr Gly Arg Ser Ala Ser Lys 
                245                 250                 255     


Leu Arg Ile Ala Gln Val Ser Pro Gly Pro Arg Asp Ser Pro Ala Phe 
            260                 265                 270         


Pro Asp Ser Pro Trp Arg Glu Arg Val Leu Ala Pro Ile Leu Pro Asp 
        275                 280                 285             


Asn Phe Ser Thr Pro Thr Gly Ser Arg Thr Asp Ser Gln Ser Val Arg 
    290                 295                 300                 


His Ser Pro Ile Ala Pro Ser Ser Pro Ser Pro Gln Val Leu Ala Gln 
305                 310                 315                 320 


Lys Tyr Ser Leu Val Ala Lys Gln Glu Ser Val Val Arg Arg Ala Ser 
                325                 330                 335     


Arg Arg Leu Ala Lys Lys Thr Ala Glu Glu Pro Ala Ala Ser Gly Arg 
            340                 345                 350         


Ile Ile Cys His Ser Tyr Leu Glu Arg Leu Leu Asn Val Glu Val Pro 
        355                 360                 365             


Gln Lys Val Gly Ser Glu Gln Lys Glu Pro Pro Glu Glu Ala Glu Pro 
    370                 375                 380                 


Val Ala Ala Ala Glu Pro Glu Val Pro Glu Asn Asn Gly Asn Asn Ser 
385                 390                 395                 400 


Trp Pro His Asn Asp Thr Glu Ile Ala Asn Ser Thr Pro Asn Pro Lys 
                405                 410                 415     


Pro Ala Ala Ser Ser Pro Glu Thr Pro Ser Ala Gly Gln Gln Glu Ala 
            420                 425                 430         


Lys Thr Asp Gln Ala Asp Gly Pro Arg Glu Pro Pro Gln Ser Ala Arg 
        435                 440                 445             


Arg Lys Arg Ser Tyr Lys Gln Ala Val Ser Glu Leu Asp Glu Glu Gln 
    450                 455                 460                 


His Leu Glu Asp Glu Glu Leu Gln Pro Pro Arg Ser Lys Thr Pro Ser 
465                 470                 475                 480 


Ser Pro Cys Pro Ala Ser Lys Val Val Arg Pro Leu Arg Thr Phe Leu 
                485                 490                 495     


His Thr Val Gln Arg Asn Gln Met Leu Met Thr Pro Thr Ser Ala Pro 
            500                 505                 510         


Arg Ser Val Met Lys Ser Phe Ile Lys Arg Asn Thr Pro Leu Arg Met 
        515                 520                 525             


Asp Pro Lys Glu Lys Glu Arg Gln Arg Leu Glu Asn Leu Arg Arg Lys 
    530                 535                 540                 


Glu Glu Ala Glu Gln Leu Arg Arg Gln Lys Val Glu Glu Asp Lys Arg 
545                 550                 555                 560 


Arg Arg Leu Glu Glu Val Lys Leu Lys Arg Glu Glu Arg Leu Arg Lys 
                565                 570                 575     


Val Leu Gln Ala Arg Glu Arg Val Glu Gln Met Lys Glu Glu Lys Lys 
            580                 585                 590         


Lys Gln Ile Glu Gln Lys Phe Ala Gln Ile Asp Glu Lys Thr Glu Lys 
        595                 600                 605             


Ala Lys Glu Glu Arg Leu Ala Glu Glu Lys Ala Lys Lys Lys Ala Ala 
    610                 615                 620                 


Ala Lys Lys Met Glu Glu Val Glu Ala Arg Arg Lys Gln Glu Glu Glu 
625                 630                 635                 640 


Ala Arg Arg Leu Arg Trp Leu Gln Gln Glu Glu Glu Glu Arg Arg His 
                645                 650                 655     


Gln Glu Leu Leu Gln Lys Lys Lys Glu Glu Glu Gln Glu Arg Leu Arg 
            660                 665                 670         


Lys Ala Ala Glu Ala Lys Arg Leu Ala Glu Gln Arg Glu Gln Glu Arg 
        675                 680                 685             


Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg 
    690                 695                 700                 


Glu Gln Glu Arg Arg Glu Gln Glu Arg Gln Leu Ala Glu Gln Glu Arg 
705                 710                 715                 720 


Arg Arg Glu Gln Glu Arg Leu Gln Ala Glu Arg Glu Leu Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Leu Arg Leu Gln Lys Glu Gln Leu Gln Arg Glu Leu Glu 
            740                 745                 750         


Glu Lys Lys Lys Lys Glu Glu Gln Gln Arg Leu Ala Glu Arg Gln Leu 
        755                 760                 765             


Gln Glu Glu Gln Glu Lys Lys Ala Lys Glu Ala Ala Gly Ala Ser Lys 
    770                 775                 780                 


Ala Leu Asn Val Thr Val Asp Val Gln Ser Pro Ala Cys Thr Ser Tyr 
785                 790                 795                 800 


Gln Met Thr Pro Gln Gly His Arg Ala Pro Pro Lys Ile Asn Pro Asp 
                805                 810                 815     


Asn Tyr Gly Met Asp Leu Asn Ser Asp Asp Ser Thr Asp Asp Glu Ala 
            820                 825                 830         


His Pro Arg Lys Pro Ile Pro Thr Trp Ala Arg Gly Thr Pro Leu Ser 
        835                 840                 845             


Gln Ala Ile Ile His Gln Tyr Tyr His Pro Pro Asn Leu Leu Glu Leu 
    850                 855                 860                 


Phe Gly Thr Ile Leu Pro Leu Asp Leu Glu Asp Ile Phe Lys Lys Ser 
865                 870                 875                 880 


Lys Pro Arg Tyr His Lys Arg Thr Ser Ser Ala Val Trp Asn Ser Pro 
                885                 890                 895     


Pro Leu Gln Gly Ala Arg Val Pro Ser Ser Leu Ala Tyr Ser Leu Lys 
            900                 905                 910         


Lys His 
        


<210> 5056
<211> 1382
<212> PRT
<213> Homo sapiens

<400> 5056
Met Asp Glu Glu Glu Asn His Tyr Val Ser Gln Leu Arg Glu Val Tyr 
1               5                   10                  15      


Ser Ser Cys Asp Thr Thr Gly Thr Gly Phe Leu Asp Arg Gln Glu Leu 
            20                  25                  30          


Thr Gln Leu Cys Leu Lys Leu His Leu Glu Gln Gln Leu Pro Val Leu 
        35                  40                  45              


Leu Gln Thr Leu Leu Gly Asn Asp His Phe Ala Arg Val Asn Phe Glu 
    50                  55                  60                  


Glu Phe Lys Glu Gly Phe Val Ala Val Leu Ser Ser Asn Ala Gly Val 
65                  70                  75                  80  


Arg Pro Ser Asp Glu Asp Ser Ser Ser Leu Glu Ser Ala Ala Ser Ser 
                85                  90                  95      


Ala Ile Pro Pro Lys Tyr Val Asn Gly Ser Lys Trp Tyr Gly Arg Arg 
            100                 105                 110         


Ser Arg Pro Glu Leu Cys Asp Ala Ala Thr Glu Ala Arg Arg Val Pro 
        115                 120                 125             


Glu Gln Gln Thr Gln Ala Ser Leu Lys Ser His Leu Trp Arg Ser Ala 
    130                 135                 140                 


Ser Leu Glu Ser Val Glu Ser Pro Lys Ser Asp Glu Glu Ala Glu Ser 
145                 150                 155                 160 


Thr Lys Glu Ala Gln Asn Glu Leu Phe Glu Ala Gln Gly Gln Leu Gln 
                165                 170                 175     


Thr Trp Asp Ser Glu Asp Phe Gly Ser Pro Gln Lys Ser Cys Ser Pro 
            180                 185                 190         


Ser Phe Asp Thr Pro Glu Ser Gln Ile Arg Gly Val Trp Glu Glu Leu 
        195                 200                 205             


Gly Val Gly Ser Ser Gly His Leu Ser Glu Gln Glu Leu Ala Val Val 
    210                 215                 220                 


Cys Gln Ser Val Gly Leu Gln Gly Leu Glu Lys Glu Glu Leu Glu Asp 
225                 230                 235                 240 


Leu Phe Asn Lys Leu Asp Gln Asp Gly Asp Gly Lys Val Ser Leu Glu 
                245                 250                 255     


Glu Phe Gln Leu Gly Leu Phe Ser His Glu Pro Ala Leu Leu Leu Glu 
            260                 265                 270         


Ser Ser Thr Arg Val Lys Pro Ser Lys Ala Trp Ser His Tyr Gln Val 
        275                 280                 285             


Pro Glu Glu Ser Gly Cys His Thr Thr Thr Thr Ser Ser Leu Val Ser 
    290                 295                 300                 


Leu Cys Ser Ser Leu Arg Leu Phe Ser Ser Ile Asp Asp Gly Ser Gly 
305                 310                 315                 320 


Phe Ala Phe Pro Asp Gln Val Leu Ala Met Trp Thr Gln Glu Gly Ile 
                325                 330                 335     


Gln Asn Gly Arg Glu Ile Leu Gln Ser Leu Asp Phe Ser Val Asp Glu 
            340                 345                 350         


Lys Val Asn Leu Leu Glu Leu Thr Trp Ala Leu Asp Asn Glu Leu Met 
        355                 360                 365             


Thr Val Asp Ser Ala Val Gln Gln Ala Ala Leu Ala Cys Tyr His Gln 
    370                 375                 380                 


Glu Leu Ser Tyr Gln Gln Gly Gln Val Glu Gln Leu Ala Arg Glu Arg 
385                 390                 395                 400 


Asp Lys Ala Arg Gln Asp Leu Glu Arg Ala Glu Lys Arg Asn Leu Glu 
                405                 410                 415     


Phe Val Lys Glu Met Asp Asp Cys His Ser Thr Leu Glu Gln Leu Thr 
            420                 425                 430         


Glu Lys Lys Ile Lys His Leu Glu Gln Gly Tyr Arg Glu Arg Leu Ser 
        435                 440                 445             


Leu Leu Arg Ser Glu Val Glu Ala Glu Arg Glu Leu Phe Trp Glu Gln 
    450                 455                 460                 


Ala His Arg Gln Arg Ala Ala Leu Glu Trp Asp Val Gly Arg Leu Gln 
465                 470                 475                 480 


Ala Glu Glu Ala Gly Leu Arg Glu Lys Leu Thr Leu Ala Leu Lys Glu 
                485                 490                 495     


Asn Ser Arg Leu Gln Lys Glu Ile Val Glu Val Val Glu Lys Leu Ser 
            500                 505                 510         


Asp Ser Glu Arg Leu Ala Leu Lys Leu Gln Lys Asp Leu Glu Phe Val 
        515                 520                 525             


Leu Lys Asp Lys Leu Glu Pro Gln Ser Ala Glu Leu Leu Ala Gln Glu 
    530                 535                 540                 


Glu Arg Phe Ala Ala Val Leu Lys Glu Tyr Glu Leu Lys Cys Arg Asp 
545                 550                 555                 560 


Leu Gln Asp Arg Asn Asp Glu Leu Gln Ala Glu Leu Glu Gly Leu Trp 
                565                 570                 575     


Ala Arg Leu Pro Lys Asn Arg His Ser Pro Ser Trp Ser Pro Asp Gly 
            580                 585                 590         


Arg Arg Arg Gln Leu Pro Gly Leu Gly Pro Ala Gly Ile Ser Phe Leu 
        595                 600                 605             


Gly Asn Ser Ala Pro Val Ser Ile Glu Thr Glu Leu Met Met Glu Gln 
    610                 615                 620                 


Val Lys Glu His Tyr Gln Asp Leu Arg Thr Gln Leu Glu Thr Lys Val 
625                 630                 635                 640 


Asn Tyr Tyr Glu Arg Glu Ile Ala Ala Leu Lys Arg Asn Phe Glu Lys 
                645                 650                 655     


Glu Arg Lys Asp Met Glu Gln Ala Arg Arg Arg Glu Val Ser Val Leu 
            660                 665                 670         


Glu Gly Gln Lys Ala Asp Leu Glu Glu Leu His Glu Lys Ser Gln Glu 
        675                 680                 685             


Val Ile Trp Gly Leu Gln Glu Gln Leu Gln Asp Thr Ala Arg Gly Pro 
    690                 695                 700                 


Glu Pro Glu Gln Met Gly Leu Ala Pro Cys Cys Thr Gln Ala Leu Cys 
705                 710                 715                 720 


Gly Leu Ala Leu Arg His His Ser His Leu Gln Gln Ile Arg Arg Glu 
                725                 730                 735     


Ala Glu Ala Glu Leu Ser Gly Glu Leu Ser Gly Leu Gly Ala Leu Pro 
            740                 745                 750         


Ala Arg Arg Asp Leu Thr Leu Glu Leu Glu Glu Pro Pro Gln Gly Pro 
        755                 760                 765             


Leu Pro Arg Gly Ser Gln Arg Ser Glu Gln Leu Glu Leu Glu Arg Ala 
    770                 775                 780                 


Leu Lys Leu Gln Pro Cys Ala Ser Glu Lys Arg Ala Gln Met Cys Val 
785                 790                 795                 800 


Ser Leu Ala Leu Glu Glu Glu Glu Leu Glu Leu Ala Arg Gly Lys Arg 
                805                 810                 815     


Val Asp Gly Pro Ser Leu Glu Ala Glu Met Gln Ala Leu Pro Lys Asp 
            820                 825                 830         


Gly Leu Val Ala Gly Ser Gly Gln Glu Gly Thr Arg Gly Leu Leu Pro 
        835                 840                 845             


Leu Arg Pro Gly Cys Gly Glu Arg Pro Leu Ala Trp Leu Ala Pro Gly 
    850                 855                 860                 


Asp Gly Arg Glu Ser Glu Glu Ala Ala Gly Ala Gly Pro Arg Arg Arg 
865                 870                 875                 880 


Gln Ala Gln Asp Thr Glu Ala Thr Gln Ser Pro Ala Pro Ala Pro Ala 
                885                 890                 895     


Pro Ala Ser His Gly Pro Ser Glu Arg Trp Ser Arg Met Gln Pro Cys 
            900                 905                 910         


Gly Val Asp Gly Asp Ile Val Pro Lys Glu Pro Glu Pro Phe Gly Ala 
        915                 920                 925             


Ser Ala Ala Gly Leu Glu Gln Pro Gly Ala Arg Glu Leu Pro Leu Leu 
    930                 935                 940                 


Gly Thr Glu Arg Asp Ala Ser Gln Thr Gln Pro Arg Met Trp Glu Pro 
945                 950                 955                 960 


Pro Leu Arg Pro Ala Ala Ser Cys Arg Gly Gln Ala Glu Arg Leu Gln 
                965                 970                 975     


Ala Ile Gln Glu Glu Arg Ala Arg Ser Trp Ser Arg Gly Thr Gln Glu 
            980                 985                 990         


Gln Ala Ser Glu Gln Gln Ala Arg  Ala Glu Gly Ala Leu  Glu Pro Gly 
        995                 1000                 1005             


Cys His  Lys His Ser Val Glu  Val Ala Arg Arg Gly  Ser Leu Pro 
    1010                 1015                 1020             


Ser His  Leu Gln Leu Ala Asp  Pro Gln Gly Ser Trp  Gln Glu Gln 
    1025                 1030                 1035             


Leu Ala  Ala Pro Glu Glu Gly  Glu Thr Lys Ile Ala  Leu Glu Arg 
    1040                 1045                 1050             


Glu Lys  Asp Asp Met Glu Thr  Lys Leu Leu His Leu  Glu Asp Val 
    1055                 1060                 1065             


Val Arg  Ala Leu Glu Lys His  Val Asp Leu Arg Glu  Asn Asp Arg 
    1070                 1075                 1080             


Leu Glu  Phe His Arg Leu Ser  Glu Glu Asn Thr Leu  Leu Lys Asn 
    1085                 1090                 1095             


Asp Leu  Gly Arg Val Arg Gln  Glu Leu Glu Ala Ala  Glu Ser Thr 
    1100                 1105                 1110             


His Asp  Ala Gln Arg Lys Glu  Ile Glu Val Leu Lys  Lys Asp Lys 
    1115                 1120                 1125             


Glu Lys  Ala Cys Ser Glu Met  Glu Val Leu Asn Arg  Gln Asn Gln 
    1130                 1135                 1140             


Asn Tyr  Lys Asp Gln Leu Ser  Gln Leu Asn Val Arg  Val Leu Gln 
    1145                 1150                 1155             


Leu Gly  Gln Glu Ala Ser Thr  His Gln Ala Gln Asn  Glu Glu His 
    1160                 1165                 1170             


Arg Val  Thr Ile Gln Met Leu  Thr Gln Ser Leu Glu  Glu Val Val 
    1175                 1180                 1185             


Arg Ser  Gly Gln Gln Gln Ser  Asp Gln Ile Gln Lys  Leu Arg Val 
    1190                 1195                 1200             


Glu Leu  Glu Cys Leu Asn Gln  Glu His Gln Ser Leu  Gln Leu Pro 
    1205                 1210                 1215             


Trp Ser  Glu Leu Thr Gln Thr  Leu Glu Glu Ser Gln  Asp Gln Val 
    1220                 1225                 1230             


Gln Gly  Ala His Leu Arg Leu  Arg Gln Ala Gln Ala  Gln His Leu 
    1235                 1240                 1245             


Gln Glu  Val Arg Leu Val Pro  Gln Asp Arg Val Ala  Glu Leu His 
    1250                 1255                 1260             


Arg Leu  Leu Ser Leu Gln Gly  Glu Gln Ala Arg Arg  Arg Leu Asp 
    1265                 1270                 1275             


Ala Gln  Arg Glu Glu His Glu  Lys Gln Leu Lys Ala  Thr Glu Glu 
    1280                 1285                 1290             


Arg Val  Glu Glu Ala Glu Met  Ile Leu Lys Asn Met  Glu Met Leu 
    1295                 1300                 1305             


Leu Gln  Glu Lys Val Asp Lys  Leu Lys Glu Gln Phe  Glu Lys Asn 
    1310                 1315                 1320             


Thr Lys  Ser Asp Leu Leu Leu  Lys Glu Leu Tyr Val  Glu Asn Ala 
    1325                 1330                 1335             


His Leu  Val Arg Ala Leu Gln  Ala Thr Glu Glu Lys  Gln Arg Gly 
    1340                 1345                 1350             


Ala Glu  Lys Gln Ser Arg Leu  Leu Glu Glu Lys Val  Arg Ala Leu 
    1355                 1360                 1365             


Asn Lys  Leu Val Ser Arg Ile  Ala Pro Ala Ala Leu  Ser Val 
    1370                 1375                 1380         


<210> 5057
<211> 1460
<212> PRT
<213> Homo sapiens

<400> 5057
Met Ala Gly Arg Pro Leu Arg Ile Gly Asp Gln Leu Val Leu Glu Glu 
1               5                   10                  15      


Asp Tyr Asp Glu Thr Tyr Ile Pro Ser Glu Gln Glu Ile Leu Glu Phe 
            20                  25                  30          


Ala Arg Glu Ile Gly Ile Asp Pro Ile Lys Glu Pro Glu Leu Met Trp 
        35                  40                  45              


Leu Ala Arg Glu Gly Ile Val Ala Pro Leu Pro Gly Glu Trp Lys Pro 
    50                  55                  60                  


Cys Gln Asp Ile Thr Gly Asp Ile Tyr Tyr Phe Asn Phe Ala Asn Gly 
65                  70                  75                  80  


Gln Ser Met Trp Asp His Pro Cys Asp Glu His Tyr Arg Ser Leu Val 
                85                  90                  95      


Ile Gln Glu Arg Ala Lys Leu Ser Thr Ser Gly Ala Ile Lys Lys Lys 
            100                 105                 110         


Lys Lys Lys Lys Glu Lys Lys Asp Lys Lys Asp Arg Asp Pro Pro Lys 
        115                 120                 125             


Ser Ser Leu Ala Leu Gly Ser Ser Leu Ala Pro Val His Val Pro Leu 
    130                 135                 140                 


Gly Gly Leu Ala Pro Leu Arg Gly Leu Val Asp Thr Pro Pro Ser Ala 
145                 150                 155                 160 


Leu Arg Gly Ser Gln Ser Val Ser Leu Gly Ser Ser Val Glu Ser Gly 
                165                 170                 175     


Arg Gln Leu Gly Glu Leu Met Leu Pro Ser Gln Gly Leu Lys Thr Ser 
            180                 185                 190         


Ala Tyr Thr Lys Gly Leu Leu Gly Ser Ile Tyr Glu Asp Lys Thr Ala 
        195                 200                 205             


Leu Ser Leu Leu Gly Leu Gly Glu Glu Thr Asn Glu Glu Asp Glu Glu 
    210                 215                 220                 


Glu Ser Asp Asn Gln Ser Val His Ser Ser Ser Glu Pro Leu Arg Asn 
225                 230                 235                 240 


Leu His Leu Asp Ile Gly Ala Leu Gly Gly Asp Phe Glu Tyr Glu Glu 
                245                 250                 255     


Ser Leu Arg Thr Ser Gln Pro Glu Glu Lys Lys Asp Val Ser Leu Asp 
            260                 265                 270         


Ser Asp Ala Ala Gly Pro Pro Thr Pro Cys Lys Pro Ser Ser Pro Gly 
        275                 280                 285             


Ala Asp Ser Ser Leu Ser Ser Ala Val Gly Lys Gly Arg Gln Gly Ser 
    290                 295                 300                 


Gly Ala Arg Pro Gly Leu Pro Glu Lys Glu Glu Asn Glu Lys Ser Glu 
305                 310                 315                 320 


Pro Lys Ile Cys Arg Asn Leu Val Thr Pro Lys Ala Asp Pro Thr Gly 
                325                 330                 335     


Ser Glu Pro Ala Lys Ala Ser Glu Lys Glu Ala Pro Glu Asp Thr Val 
            340                 345                 350         


Asp Ala Gly Glu Glu Gly Ser Arg Arg Glu Glu Ala Ala Lys Glu Pro 
        355                 360                 365             


Lys Lys Lys Ala Ser Ala Leu Glu Glu Gly Ser Ser Asp Ala Ser Gln 
    370                 375                 380                 


Glu Leu Glu Ile Ser Glu His Met Lys Glu Pro Gln Leu Ser Asp Ser 
385                 390                 395                 400 


Ile Ala Ser Asp Pro Lys Ser Phe His Gly Leu Asp Phe Gly Phe Arg 
                405                 410                 415     


Ser Arg Ile Ser Glu His Leu Leu Asp Val Asp Val Leu Ser Pro Val 
            420                 425                 430         


Leu Gly Gly Ala Cys Arg Gln Ala Gln Gln Pro Leu Gly Ile Glu Asp 
        435                 440                 445             


Lys Asp Asp Ser Gln Ser Ser Gln Asp Glu Leu Gln Ser Lys Gln Ser 
    450                 455                 460                 


Lys Gly Leu Glu Glu Arg Leu Ser Pro Pro Leu Pro His Glu Glu Arg 
465                 470                 475                 480 


Ala Gln Ser Pro Pro Arg Ser Leu Ala Thr Glu Glu Glu Pro Pro Gln 
                485                 490                 495     


Gly Pro Glu Gly Gln Pro Glu Trp Lys Glu Ala Glu Glu Leu Gly Glu 
            500                 505                 510         


Asp Ser Ala Ala Ser Leu Ser Leu Gln Leu Ser Leu Gln Arg Glu Gln 
        515                 520                 525             


Ala Pro Ser Pro Pro Ala Ala Cys Glu Lys Gly Lys Glu Gln His Ser 
    530                 535                 540                 


Gln Ala Glu Glu Leu Gly Pro Gly Gln Glu Glu Ala Glu Asp Pro Glu 
545                 550                 555                 560 


Glu Lys Val Ala Val Ser Pro Thr Pro Pro Val Ser Pro Glu Val Arg 
                565                 570                 575     


Ser Thr Glu Pro Val Ala Pro Pro Glu Gln Leu Ser Glu Ala Ala Leu 
            580                 585                 590         


Lys Ala Met Glu Glu Ala Val Ala Gln Val Leu Glu Gln Asp Gln Arg 
        595                 600                 605             


His Leu Leu Glu Ser Lys Gln Glu Lys Met Gln Gln Leu Arg Glu Lys 
    610                 615                 620                 


Leu Cys Gln Glu Glu Glu Glu Glu Ile Leu Arg Leu His Gln Gln Lys 
625                 630                 635                 640 


Glu Gln Ser Leu Ser Ser Leu Arg Glu Arg Leu Gln Lys Ala Ile Glu 
                645                 650                 655     


Glu Glu Glu Ala Arg Met Arg Glu Glu Glu Ser Gln Arg Leu Ser Trp 
            660                 665                 670         


Leu Arg Ala Gln Val Gln Ser Ser Thr Gln Ala Asp Glu Asp Gln Ile 
        675                 680                 685             


Arg Ala Glu Gln Glu Ala Ser Leu Gln Lys Leu Arg Glu Glu Leu Glu 
    690                 695                 700                 


Ser Gln Gln Lys Ala Glu Arg Ala Ser Leu Glu Gln Lys Asn Arg Gln 
705                 710                 715                 720 


Met Leu Glu Gln Leu Lys Glu Glu Ile Glu Ala Ser Glu Lys Ser Glu 
                725                 730                 735     


Gln Ala Ala Leu Asn Ala Ala Lys Glu Lys Ala Leu Gln Gln Leu Arg 
            740                 745                 750         


Glu Gln Leu Glu Gly Glu Arg Lys Glu Ala Val Ala Thr Leu Glu Lys 
        755                 760                 765             


Glu His Ser Ala Glu Leu Glu Arg Leu Cys Ser Ser Leu Glu Ala Lys 
    770                 775                 780                 


His Arg Glu Val Val Ser Ser Leu Gln Lys Lys Ile Gln Glu Ala Gln 
785                 790                 795                 800 


Gln Lys Glu Glu Ala Gln Leu Gln Lys Cys Leu Gly Gln Val Glu His 
                805                 810                 815     


Arg Val His Gln Lys Ser Tyr His Val Ala Gly Tyr Glu His Glu Leu 
            820                 825                 830         


Ser Ser Leu Leu Arg Glu Lys Arg Gln Glu Val Glu Gly Glu His Glu 
        835                 840                 845             


Arg Arg Leu Asp Lys Met Lys Glu Glu His Gln Gln Val Met Ala Lys 
    850                 855                 860                 


Ala Arg Glu Gln Tyr Glu Ala Glu Glu Arg Lys Gln Arg Ala Glu Leu 
865                 870                 875                 880 


Leu Gly His Leu Thr Gly Glu Leu Glu Arg Leu Gln Arg Ala His Glu 
                885                 890                 895     


Arg Glu Leu Glu Thr Val Arg Gln Glu Gln His Lys Arg Leu Glu Asp 
            900                 905                 910         


Leu Arg Arg Arg His Arg Glu Gln Glu Arg Lys Leu Gln Asp Leu Glu 
        915                 920                 925             


Leu Asp Leu Glu Thr Arg Ala Lys Asp Val Lys Ala Arg Leu Ala Leu 
    930                 935                 940                 


Leu Glu Val Gln Glu Glu Thr Ala Arg Arg Glu Lys Gln Gln Leu Leu 
945                 950                 955                 960 


Asp Val Gln Arg Gln Val Ala Leu Lys Ser Glu Glu Ala Thr Ala Thr 
                965                 970                 975     


His Gln Gln Leu Glu Glu Ala Gln Lys Glu His Thr His Leu Leu Gln 
            980                 985                 990         


Ser Asn Gln Gln Leu Arg Glu Ile  Leu Asp Glu Leu Gln  Ala Arg Lys 
        995                 1000                 1005             


Leu Lys  Leu Glu Ser Gln Val  Asp Leu Leu Gln Ala  Gln Ser Gln 
    1010                 1015                 1020             


Gln Leu  Gln Lys His Phe Ser  Ser Leu Glu Ala Glu  Ala Gln Lys 
    1025                 1030                 1035             


Lys Gln  His Leu Leu Arg Glu  Val Thr Val Glu Glu  Asn Asn Ala 
    1040                 1045                 1050             


Ser Pro  His Phe Glu Pro Asp  Leu His Ile Glu Asp  Leu Arg Lys 
    1055                 1060                 1065             


Ser Leu  Gly Thr Asn Gln Thr  Lys Glu Val Ser Ser  Ser Leu Ser 
    1070                 1075                 1080             


Gln Ser  Lys Glu Asp Leu Tyr  Leu Asp Ser Leu Ser  Ser His Asn 
    1085                 1090                 1095             


Val Trp  His Leu Leu Ser Ala  Glu Gly Val Ala Leu  Arg Ser Ala 
    1100                 1105                 1110             


Lys Glu  Phe Leu Val Gln Gln  Thr Arg Ser Met Arg  Arg Arg Gln 
    1115                 1120                 1125             


Thr Ala  Leu Lys Ala Ala Gln  Gln His Trp Arg His  Glu Leu Ala 
    1130                 1135                 1140             


Ser Ala  Gln Glu Val Ala Lys  Asp Pro Pro Gly Ile  Lys Ala Leu 
    1145                 1150                 1155             


Glu Asp  Met Arg Lys Asn Leu  Glu Lys Glu Thr Arg  His Leu Asp 
    1160                 1165                 1170             


Glu Met  Lys Ser Ala Met Arg  Lys Gly His Asn Leu  Leu Lys Lys 
    1175                 1180                 1185             


Lys Glu  Glu Lys Leu Asn Gln  Leu Glu Ser Ser Leu  Trp Glu Glu 
    1190                 1195                 1200             


Ala Ser  Asp Glu Gly Thr Leu  Gly Gly Ser Pro Thr  Lys Lys Ala 
    1205                 1210                 1215             


Val Thr  Phe Asp Leu Ser Asp  Met Asp Ser Leu Ser  Ser Glu Ser 
    1220                 1225                 1230             


Ser Glu  Ser Phe Ser Pro Pro  His Arg Glu Trp Trp  Arg Gln Gln 
    1235                 1240                 1245             


Arg Ile  Asp Ser Thr Pro Ser  Leu Thr Ser Arg Lys  Ile His Gly 
    1250                 1255                 1260             


Leu Ser  His Ser Leu Arg Gln  Ile Ser Ser Gln Leu  Ser Ser Val 
    1265                 1270                 1275             


Leu Ser  Ile Leu Asp Ser Leu  Asn Pro Gln Ser Pro  Pro Pro Leu 
    1280                 1285                 1290             


Leu Ala  Ser Met Pro Ala Gln  Leu Pro Pro Arg Asp  Pro Lys Ser 
    1295                 1300                 1305             


Thr Pro  Thr Pro Thr Tyr Tyr  Gly Ser Leu Ala Arg  Phe Ser Ala 
    1310                 1315                 1320             


Leu Ser  Ser Ala Thr Pro Thr  Ser Thr Gln Trp Ala  Trp Asp Ser 
    1325                 1330                 1335             


Gly Gln  Gly Pro Arg Leu Pro  Ser Ser Val Ala Gln  Thr Val Asp 
    1340                 1345                 1350             


Asp Phe  Leu Leu Glu Lys Trp  Arg Lys Tyr Phe Pro  Ser Gly Ile 
    1355                 1360                 1365             


Pro Leu  Leu Ser Asn Ser Pro  Thr Pro Leu Glu Ser  Arg Leu Gly 
    1370                 1375                 1380             


Tyr Met  Ser Ala Ser Glu Gln  Leu Arg Leu Leu Gln  His Ser His 
    1385                 1390                 1395             


Ser Gln  Val Pro Glu Ala Gly  Ser Thr Thr Phe Gln  Gly Ile Ile 
    1400                 1405                 1410             


Glu Ala  Asn Arg Arg Trp Leu  Glu Arg Val Lys Asn  Asp Pro Arg 
    1415                 1420                 1425             


Leu Pro  Leu Phe Ser Ser Thr  Pro Lys Pro Lys Ala  Thr Leu Ser 
    1430                 1435                 1440             


Leu Leu  Gln Leu Gly Leu Asp  Glu His Asn Arg Val  Lys Val Tyr 
    1445                 1450                 1455             


Arg Phe  
    1460 


<210> 5058
<211> 626
<212> PRT
<213> Homo sapiens

<400> 5058
Met Met Ala Asn Asp Ala Lys Pro Asp Val Lys Thr Val Gln Val Leu 
1               5                   10                  15      


Arg Asp Thr Ala Asn Arg Leu Arg Ile His Ser Ile Arg Ala Thr Cys 
            20                  25                  30          


Ala Ser Gly Ser Gly Gln Leu Thr Ser Cys Cys Ser Ala Ala Glu Val 
        35                  40                  45              


Val Ser Val Leu Phe Phe His Thr Met Lys Tyr Lys Gln Thr Asp Pro 
    50                  55                  60                  


Glu His Pro Asp Asn Asp Arg Phe Ile Leu Ser Arg Gly His Ala Ala 
65                  70                  75                  80  


Pro Ile Leu Tyr Ala Ala Trp Val Glu Val Gly Asp Ile Ser Glu Ser 
                85                  90                  95      


Asp Leu Leu Asn Leu Arg Lys Leu His Ser Asp Leu Glu Arg His Pro 
            100                 105                 110         


Thr Pro Arg Leu Pro Phe Val Asp Val Ala Thr Gly Ser Leu Gly Gln 
        115                 120                 125             


Gly Leu Gly Thr Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Leu Asp 
    130                 135                 140                 


Lys Ala Ser Tyr Arg Val Phe Cys Leu Met Gly Asp Gly Glu Ser Ser 
145                 150                 155                 160 


Glu Gly Ser Val Trp Glu Ala Phe Ala Phe Ala Ser His Tyr Asn Leu 
                165                 170                 175     


Asp Asn Leu Val Ala Val Phe Asp Val Asn Arg Leu Gly Gln Ser Gly 
            180                 185                 190         


Pro Ala Pro Leu Glu His Gly Ala Asp Ile Tyr Gln Asn Cys Cys Glu 
        195                 200                 205             


Ala Phe Gly Trp Asn Thr Tyr Leu Val Asp Gly His Asp Val Glu Ala 
    210                 215                 220                 


Leu Cys Gln Ala Phe Trp Gln Ala Ser Gln Val Lys Asn Lys Pro Thr 
225                 230                 235                 240 


Ala Ile Val Ala Lys Thr Phe Lys Gly Arg Gly Ile Pro Asn Ile Glu 
                245                 250                 255     


Asp Ala Glu Asn Trp His Gly Lys Pro Val Pro Lys Glu Arg Ala Asp 
            260                 265                 270         


Ala Ile Val Lys Leu Ile Glu Ser Gln Ile Gln Thr Asn Glu Asn Leu 
        275                 280                 285             


Ile Pro Lys Ser Pro Val Glu Asp Ser Pro Gln Ile Ser Ile Thr Asp 
    290                 295                 300                 


Ile Lys Met Thr Ser Pro Pro Ala Tyr Lys Val Gly Asp Lys Ile Ala 
305                 310                 315                 320 


Thr Gln Lys Thr Tyr Gly Leu Ala Leu Ala Lys Leu Gly Arg Ala Asn 
                325                 330                 335     


Glu Arg Val Ile Val Leu Ser Gly Asp Thr Met Asn Ser Thr Phe Ser 
            340                 345                 350         


Glu Ile Phe Arg Lys Glu His Pro Glu Arg Phe Ile Glu Cys Ile Ile 
        355                 360                 365             


Ala Glu Gln Asn Met Val Ser Val Ala Leu Gly Cys Ala Thr Arg Gly 
    370                 375                 380                 


Arg Thr Ile Ala Phe Ala Gly Ala Phe Ala Ala Phe Phe Thr Arg Ala 
385                 390                 395                 400 


Phe Asp Gln Leu Arg Met Gly Ala Ile Ser Gln Ala Asn Ile Asn Leu 
                405                 410                 415     


Ile Gly Ser His Cys Gly Val Ser Thr Gly Glu Asp Gly Val Ser Gln 
            420                 425                 430         


Met Ala Leu Glu Asp Leu Ala Met Phe Arg Ser Ile Pro Asn Cys Thr 
        435                 440                 445             


Val Phe Tyr Pro Ser Asp Ala Ile Ser Thr Glu His Ala Ile Tyr Leu 
    450                 455                 460                 


Ala Ala Asn Thr Lys Gly Met Cys Phe Ile Arg Thr Ser Gln Pro Glu 
465                 470                 475                 480 


Thr Ala Val Ile Tyr Thr Pro Gln Glu Asn Phe Glu Ile Gly Gln Ala 
                485                 490                 495     


Lys Val Val Arg His Gly Val Asn Asp Lys Val Thr Val Ile Gly Ala 
            500                 505                 510         


Gly Val Thr Leu His Glu Ala Leu Glu Ala Ala Asp His Leu Ser Gln 
        515                 520                 525             


Gln Gly Ile Ser Val Arg Val Ile Asp Pro Phe Thr Ile Lys Pro Leu 
    530                 535                 540                 


Asp Ala Ala Thr Ile Ile Ser Ser Ala Lys Ala Thr Gly Gly Arg Val 
545                 550                 555                 560 


Ile Thr Val Glu Asp His Tyr Arg Glu Gly Gly Ile Gly Glu Ala Val 
                565                 570                 575     


Cys Ala Ala Val Ser Arg Glu Pro Asp Ile Leu Val His Gln Leu Ala 
            580                 585                 590         


Val Ser Gly Val Pro Gln Arg Gly Lys Thr Ser Glu Leu Leu Asp Met 
        595                 600                 605             


Phe Gly Ile Ser Thr Arg His Ile Ile Ala Ala Val Thr Leu Thr Leu 
    610                 615                 620                 


Met Lys 
625     


<210> 5059
<211> 332
<212> PRT
<213> Homo sapiens

<400> 5059
Met Ala Thr Ile Lys Ser Glu Leu Ile Lys Asn Phe Ala Glu Glu Glu 
1               5                   10                  15      


Ala Ile His His Asn Lys Ile Ser Ile Val Gly Thr Gly Ser Val Gly 
            20                  25                  30          


Val Ala Cys Ala Ile Ser Ile Leu Leu Lys Gly Leu Ser Asp Glu Leu 
        35                  40                  45              


Val Leu Val Asp Val Asp Glu Gly Lys Leu Lys Gly Glu Thr Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Pro Phe Met Lys Met Pro Asn Ile Val Ser Ser 
65                  70                  75                  80  


Lys Asp Tyr Leu Val Thr Ala Asn Ser Asn Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Lys Lys Gly Glu Thr Arg Leu Asp Leu Val Gln Arg 
            100                 105                 110         


Asn Val Ser Ile Phe Lys Leu Met Ile Pro Asn Ile Thr Gln Tyr Ser 
        115                 120                 125             


Pro His Cys Lys Leu Leu Ile Val Thr Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Leu Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Phe Ile Gly Gln 
                165                 170                 175     


Arg Leu Gly Ile His Ser Glu Ser Cys His Gly Leu Ile Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Val Asn Ile Ala Gly 
        195                 200                 205             


Val Pro Leu Lys Asp Leu Asn Pro Asp Ile Gly Thr Asp Lys Asp Pro 
    210                 215                 220                 


Glu Gln Trp Glu Asn Val His Lys Lys Val Ile Ser Ser Gly Tyr Glu 
225                 230                 235                 240 


Met Val Lys Met Lys Gly Tyr Thr Ser Trp Gly Ile Ser Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Thr Glu Ser Ile Leu Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Leu Ser Lys Gly Leu Tyr Gly Ile Asn Glu Asp Ile Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Glu Asn Gly Ile Thr Asp Leu Ile 
    290                 295                 300                 


Lys Val Lys Leu Thr Leu Glu Glu Glu Ala Cys Leu Gln Lys Ser Ala 
305                 310                 315                 320 


Glu Thr Leu Trp Glu Ile Gln Lys Glu Leu Lys Leu 
                325                 330         


<210> 5060
<211> 323
<212> PRT
<213> Homo sapiens

<400> 5060
Met Pro Glu Met Pro Glu Asp Met Glu Gln Glu Glu Val Asn Ile Pro 
1               5                   10                  15      


Asn Arg Arg Val Leu Val Thr Gly Ala Thr Gly Leu Leu Gly Arg Ala 
            20                  25                  30          


Val His Lys Glu Phe Gln Gln Asn Asn Trp His Ala Val Gly Cys Gly 
        35                  40                  45              


Phe Arg Arg Ala Arg Pro Lys Phe Glu Gln Val Asn Leu Leu Asp Ser 
    50                  55                  60                  


Asn Ala Val His His Ile Ile His Asp Phe Gln Pro His Val Ile Val 
65                  70                  75                  80  


His Cys Ala Ala Glu Arg Arg Pro Asp Val Val Glu Asn Gln Pro Asp 
                85                  90                  95      


Ala Ala Ser Gln Leu Asn Val Asp Ala Ser Gly Asn Leu Ala Lys Glu 
            100                 105                 110         


Ala Ala Ala Val Gly Ala Phe Leu Ile Tyr Ile Ser Ser Asp Tyr Val 
        115                 120                 125             


Phe Asp Gly Thr Asn Pro Pro Tyr Arg Glu Glu Asp Ile Pro Ala Pro 
    130                 135                 140                 


Leu Asn Leu Tyr Gly Lys Thr Lys Leu Asp Gly Glu Lys Ala Val Leu 
145                 150                 155                 160 


Glu Asn Asn Leu Gly Ala Ala Val Leu Arg Ile Pro Ile Leu Tyr Gly 
                165                 170                 175     


Glu Val Glu Lys Leu Glu Glu Ser Ala Val Thr Val Met Phe Asp Lys 
            180                 185                 190         


Val Gln Phe Ser Asn Lys Ser Ala Asn Met Asp His Trp Gln Gln Arg 
        195                 200                 205             


Phe Pro Thr His Val Lys Asp Val Ala Thr Val Cys Arg Gln Leu Ala 
    210                 215                 220                 


Glu Lys Arg Met Leu Asp Pro Ser Ile Lys Gly Thr Phe His Trp Ser 
225                 230                 235                 240 


Gly Asn Glu Gln Met Thr Lys Tyr Glu Met Ala Cys Ala Ile Ala Asp 
                245                 250                 255     


Ala Phe Asn Leu Pro Ser Ser His Leu Arg Pro Ile Thr Asp Ser Pro 
            260                 265                 270         


Val Leu Gly Ala Gln Arg Pro Arg Asn Ala Gln Leu Asp Cys Ser Lys 
        275                 280                 285             


Leu Glu Thr Leu Gly Ile Gly Gln Arg Thr Pro Phe Arg Ile Gly Ile 
    290                 295                 300                 


Lys Glu Ser Leu Trp Pro Phe Leu Ile Asp Lys Arg Trp Arg Gln Thr 
305                 310                 315                 320 


Val Phe His 
            


<210> 5061
<211> 1094
<212> PRT
<213> Homo sapiens

<400> 5061
Met Ala Glu Ser Ser Ser Glu Ser Asp His Phe Arg Cys Arg Asp Arg 
1               5                   10                  15      


Leu Ser Pro Trp Ala Ala Arg Ser Thr His Arg Gly Thr Arg Ser Leu 
            20                  25                  30          


Pro Thr Val Glu Val Thr Glu Lys Val Asn Thr Ile Thr Ser Thr Leu 
        35                  40                  45              


Gln Asp Thr Ser Arg Asn Leu Arg Gln Val Asp Gln Met Leu Gly Arg 
    50                  55                  60                  


Tyr Arg Glu Tyr Ser Asn Gly Gln Ala Gly Ala Ile Glu His Leu Lys 
65                  70                  75                  80  


Glu Ser Leu Glu Gln Ser Ile Asp Gln Leu Arg Ser Gln Arg Leu Leu 
                85                  90                  95      


Arg Asn Ser Gly Gly Arg Ser Ile Ser Val Thr Ser Leu Ser Ala Ser 
            100                 105                 110         


Asp Leu Asp Gly Gly Thr Gly Ser Glu Leu His His Phe Pro Pro Thr 
        115                 120                 125             


Ser Pro Leu Lys Asp Tyr Gly Asp Pro Gln Gly Ile Lys Arg Met Arg 
    130                 135                 140                 


Ser Arg Thr Gly Val Arg Phe Val Gln Glu Thr Asp Asp Met Thr Gln 
145                 150                 155                 160 


Leu His Gly Phe His Gln Ser Leu Arg Asp Leu Ser Ser Glu Gln Ile 
                165                 170                 175     


Arg Leu Gly Asp Asp Phe Asn Arg Glu Leu Ser Arg Arg Ser Arg Ser 
            180                 185                 190         


Asp Ala Glu Thr Lys Arg Ala Leu Glu Glu Leu Thr Glu Lys Leu Asn 
        195                 200                 205             


Glu Ala Gln Lys Gln Glu Val Val Ser Asp Arg Val Glu Arg Arg Leu 
    210                 215                 220                 


Gln Glu Leu Glu Arg Glu Met Arg Thr Glu Arg Glu Leu Val Glu Arg 
225                 230                 235                 240 


Arg Gln Asp Gln Leu Gly Leu Met Ser Leu Gln Leu Gln Glu Ala Leu 
                245                 250                 255     


Lys Lys Gln Glu Ala Lys Ala Asp Glu His Glu Gly Ala Ile Lys Asn 
            260                 265                 270         


Lys Leu Arg Gln Thr Glu Thr Glu Lys Asn Gln Leu Glu Gln Glu Leu 
        275                 280                 285             


Glu Leu Ser Arg Arg Leu Leu Asn Gln Ser Glu Gly Ser Arg Glu Thr 
    290                 295                 300                 


Leu Leu His Gln Val Glu Glu Leu Arg Thr Gln Leu Thr Lys Ala Glu 
305                 310                 315                 320 


Gly Asp Arg Lys Gly Leu Gln His Gln Val Ser Gln Ile Ser Lys Gln 
                325                 330                 335     


Gln Ser Asn Tyr Gln Asp Glu Gln Gly Glu Asp Trp Arg Phe Arg Arg 
            340                 345                 350         


Gly Val Glu Arg Glu Lys Gln Asp Leu Glu Lys Gln Met Ser Asp Leu 
        355                 360                 365             


Arg Val Gln Leu Asn Phe Ser Ala Met Ala Ser Glu Leu Glu Glu Val 
    370                 375                 380                 


Lys Arg Cys Met Glu Arg Lys Asp Lys Glu Lys Ala His Leu Ala Ser 
385                 390                 395                 400 


Gln Val Glu Asn Leu Thr Arg Glu Leu Glu Asn Gly Glu Lys Gln Gln 
                405                 410                 415     


Leu Gln Met Leu Asp Arg Leu Lys Glu Ile Gln Asn His Phe Asp Thr 
            420                 425                 430         


Cys Glu Ala Glu Arg Lys His Ala Asp Leu Gln Ile Ser Glu Leu Thr 
        435                 440                 445             


Arg His Ala Glu Asp Ala Thr Lys Gln Ala Glu Arg Tyr Leu Ser Glu 
    450                 455                 460                 


Leu Gln Gln Ser Glu Ala Leu Lys Glu Glu Ala Glu Lys Arg Arg Glu 
465                 470                 475                 480 


Asp Leu Lys Leu Lys Ala Gln Glu Ser Ile Arg Gln Trp Lys Leu Lys 
                485                 490                 495     


His Lys Lys Leu Glu Arg Ala Leu Glu Lys Gln Ser Glu Thr Val Asp 
            500                 505                 510         


Glu Leu Thr Gly Lys Asn Asn Gln Ile Leu Lys Glu Lys Asp Glu Leu 
        515                 520                 525             


Lys Thr Gln Leu Tyr Ala Ala Leu Gln Gln Ile Glu Asn Leu Arg Lys 
    530                 535                 540                 


Glu Leu Asn Asp Val Leu Thr Lys Arg Ala Leu Gln Glu Glu Glu Leu 
545                 550                 555                 560 


His Ser Lys Glu Glu Lys Leu Arg Asp Ile Lys Ser His Gln Ala Asp 
                565                 570                 575     


Leu Glu Leu Glu Val Lys Asn Ser Leu Asp Thr Ile His Arg Leu Glu 
            580                 585                 590         


Ser Glu Leu Lys Lys Gln Ser Lys Ile Gln Ser Gln Met Lys Val Glu 
        595                 600                 605             


Lys Ala His Leu Glu Glu Glu Ile Ala Glu Leu Lys Lys Ser Gln Ala 
    610                 615                 620                 


Gln Asp Lys Ala Lys Leu Leu Glu Met Gln Glu Ser Ile Lys Asp Leu 
625                 630                 635                 640 


Ser Ala Ile Arg Ala Asp Leu Ala Asn Lys Leu Ala Glu Glu Glu Arg 
                645                 650                 655     


Ala Lys Lys Ala Val Leu Lys Asp Leu Ser Asp Leu Thr Ala Gln Ala 
            660                 665                 670         


Lys Ser Arg Asp Glu Glu Thr Ala Thr Ile Ile Thr Gln Leu Lys Leu 
        675                 680                 685             


Glu Arg Asp Val His Gln Arg Glu Leu Lys Asp Leu Thr Ser Ser Leu 
    690                 695                 700                 


Gln Ser Val Lys Thr Lys His Glu Gln Asn Ile Gln Glu Leu Met Lys 
705                 710                 715                 720 


His Phe Lys Lys Glu Lys Ser Glu Ala Glu Asn His Ile Arg Thr Leu 
                725                 730                 735     


Lys Ala Glu Ser Leu Glu Glu Lys Asn Met Ala Lys Ile His Arg Gly 
            740                 745                 750         


Gln Leu Glu Lys Leu Lys Ser Gln Cys Asp Arg Leu Thr Glu Glu Leu 
        755                 760                 765             


Thr Gln Asn Glu Asn Glu Asn Lys Lys Leu Lys Leu Lys Tyr Gln Cys 
    770                 775                 780                 


Leu Lys Asp Gln Leu Glu Glu Arg Glu Lys His Ile Ser Ile Glu Glu 
785                 790                 795                 800 


Glu His Leu Arg Arg Met Glu Glu Ala Arg Leu Gln Leu Lys Asp Gln 
                805                 810                 815     


Leu Leu Cys Leu Glu Thr Glu Gln Glu Ser Ile Leu Gly Val Ile Gly 
            820                 825                 830         


Lys Glu Ile Asp Ala Ala Cys Lys Thr Phe Ser Lys Asp Ser Val Glu 
        835                 840                 845             


Lys Leu Lys Val Phe Ser Ser Gly Pro Asp Ile His Tyr Asp Pro His 
    850                 855                 860                 


Arg Trp Leu Ala Glu Ser Lys Thr Lys Leu Gln Trp Leu Cys Glu Glu 
865                 870                 875                 880 


Leu Lys Glu Arg Glu Asn Arg Glu Lys Asn Leu Arg His Gln Leu Met 
                885                 890                 895     


Leu Cys Arg Gln Gln Leu Arg Asn Leu Thr Glu Asn Lys Glu Ser Glu 
            900                 905                 910         


Leu Gln Cys Leu Phe Gln Gln Ile Glu Arg Gln Glu Gln Leu Leu Asp 
        915                 920                 925             


Glu Ile His Arg Glu Lys Arg Asp Leu Leu Glu Glu Thr Gln Arg Lys 
    930                 935                 940                 


Asp Glu Glu Met Gly Ser Leu Gln Asp Arg Val Ile Ala Leu Glu Thr 
945                 950                 955                 960 


Ser Thr Gln Val Ala Leu Asp His Leu Glu Ser Val Pro Glu Lys Leu 
                965                 970                 975     


Ser Leu Leu Glu Asp Phe Lys Asp Phe Arg Asp Ser Cys Ser Ser Ser 
            980                 985                 990         


Glu Arg Thr Asp Gly Arg Tyr Ser  Lys Tyr Arg Val Arg  Arg Asn Ser 
        995                 1000                 1005             


Leu Gln  His His Gln Asp Asp  Thr Lys Tyr Arg Thr  Lys Ser Phe 
    1010                 1015                 1020             


Lys Gly  Asp Arg Thr Phe Leu  Glu Gly Ser His Thr  Arg Gly Leu 
    1025                 1030                 1035             


Asp His  Ser Ser Ser Trp Gln  Asp His Ser Arg Phe  Leu Ser Ser 
    1040                 1045                 1050             


Pro Arg  Phe Ser Tyr Val Asn  Ser Phe Thr Lys Arg  Thr Val Ala 
    1055                 1060                 1065             


Pro Asp  Ser Ala Ser Asn Lys  Glu Asp Ala Thr Met  Asn Gly Thr 
    1070                 1075                 1080             


Ser Ser  Gln Pro Lys Lys Glu  Glu Tyr Gly Ser 
    1085                 1090                 


<210> 5062
<211> 336
<212> PRT
<213> Homo sapiens

<400> 5062
Met Lys Lys Glu His Val Leu His Cys Gln Phe Ser Ala Trp Tyr Pro 
1               5                   10                  15      


Phe Phe Arg Gly Val Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
            20                  25                  30          


Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
        35                  40                  45              


Arg Asp Asp Pro Pro Thr His Ser Gln Pro Asp Ser Asp Asp Glu Ala 
    50                  55                  60                  


Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn Thr Ala Thr Leu Thr Ala 
65                  70                  75                  80  


Pro Glu Phe Pro Glu Phe Ala Thr Lys Val Gln Glu Ala Ile Asn Ser 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Pro Lys Leu Asn Trp Ser Ala Pro Arg Asp 
            100                 105                 110         


Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Thr Leu Ser 
        115                 120                 125             


Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr Arg Asp Phe 
    130                 135                 140                 


Thr Gln Pro Phe Ile His Cys Thr Asp Asp Ser Pro Asp Pro Cys Ile 
145                 150                 155                 160 


Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
                165                 170                 175     


Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln 
            180                 185                 190         


Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu 
        195                 200                 205             


Ile Arg Arg Cys Ile Gln Asp Phe Phe Lys Lys His Ile Gln Tyr Lys 
    210                 215                 220                 


Phe Leu Asp Glu Asp Phe Val Phe Asp Ile Tyr Arg Asp Ser Arg Gly 
225                 230                 235                 240 


Lys Val Trp Leu Ile Asp Phe Asn Pro Phe Gly Glu Val Thr Asp Ser 
                245                 250                 255     


Leu Leu Phe Thr Trp Glu Glu Leu Ile Ser Glu Asn Asn Leu Asn Gly 
            260                 265                 270         


Asp Phe Ser Glu Val Asp Ala Gln Glu Gln Asp Ser Pro Ala Phe Arg 
        275                 280                 285             


Cys Thr Asn Ser Glu Val Thr Val Gln Pro Ser Pro Tyr Leu Ser Tyr 
    290                 295                 300                 


Arg Leu Pro Lys Asp Phe Val Asp Leu Ser Thr Gly Glu Asp Ala His 
305                 310                 315                 320 


Lys Leu Ile Asp Phe Leu Lys Leu Lys Arg Asn Gln Gln Glu Asp Asp 
                325                 330                 335     


<210> 5063
<211> 415
<212> PRT
<213> Homo sapiens

<400> 5063
Met Lys Leu Ser Leu Thr Lys Val Val Asn Gly Cys Arg Leu Gly Lys 
1               5                   10                  15      


Ile Lys Asn Leu Gly Lys Thr Gly Asp His Thr Met Asp Ile Pro Gly 
            20                  25                  30          


Cys Leu Leu Tyr Thr Lys Thr Gly Ser Ala Pro His Leu Thr His His 
        35                  40                  45              


Thr Leu His Asn Ile His Gly Val Pro Ala Met Ala Gln Leu Thr Leu 
    50                  55                  60                  


Ser Ser Leu Ala Glu His His Glu Val Leu Thr Glu Tyr Lys Glu Gly 
65                  70                  75                  80  


Val Gly Lys Phe Ile Gly Met Pro Glu Ser Leu Leu Tyr Cys Ser Leu 
                85                  90                  95      


His Asp Pro Val Ser Pro Cys Pro Ala Gly Tyr Val Thr Asn Lys Ser 
            100                 105                 110         


Val Ser Val Trp Ser Val Ala Gly Arg Val Glu Met Thr Val Ser Lys 
        115                 120                 125             


Phe Met Ala Ile Gln Lys Ala Leu Gln Pro Asp Trp Phe Gln Cys Leu 
    130                 135                 140                 


Ser Asp Gly Glu Val Ser Cys Lys Glu Ala Thr Ser Ile Lys Arg Val 
145                 150                 155                 160 


Arg Lys Ser Val Asp Arg Ser Leu Leu Phe Leu Asp Asn Cys Leu Arg 
                165                 170                 175     


Leu Gln Glu Glu Ser Glu Val Leu Gln Lys Ser Val Ile Ile Gly Val 
            180                 185                 190         


Ile Glu Gly Gly Asp Val Met Glu Glu Arg Leu Arg Ser Ala Arg Glu 
        195                 200                 205             


Thr Ala Lys Arg Pro Val Gly Gly Phe Leu Leu Asp Gly Phe Gln Gly 
    210                 215                 220                 


Asn Pro Thr Thr Leu Glu Ala Arg Leu Arg Leu Leu Ser Ser Val Thr 
225                 230                 235                 240 


Ala Glu Leu Pro Glu Asp Lys Pro Arg Leu Ile Ser Gly Val Ser Arg 
                245                 250                 255     


Pro Asp Glu Val Leu Glu Cys Ile Glu Arg Gly Val Asp Leu Phe Glu 
            260                 265                 270         


Ser Phe Phe Pro Tyr Gln Val Thr Glu Arg Gly Cys Ala Leu Thr Phe 
        275                 280                 285             


Ser Phe Asp Tyr Gln Pro Asn Pro Glu Glu Thr Leu Leu Gln Gln Asn 
    290                 295                 300                 


Gly Thr Gln Glu Glu Ile Lys Cys Met Asp Gln Ile Lys Lys Ile Glu 
305                 310                 315                 320 


Thr Thr Gly Cys Asn Gln Glu Ile Thr Ser Phe Glu Ile Asn Leu Lys 
                325                 330                 335     


Glu Lys Lys Tyr Gln Glu Asp Phe Asn Pro Leu Val Arg Gly Cys Ser 
            340                 345                 350         


Cys Tyr Cys Cys Lys Asn His Thr Arg Ala Tyr Ile His His Leu Leu 
        355                 360                 365             


Val Thr Asn Glu Leu Leu Ala Gly Val Leu Leu Met Met His Asn Phe 
    370                 375                 380                 


Glu His Tyr Phe Gly Phe Phe His Tyr Ile Arg Glu Ala Leu Lys Ser 
385                 390                 395                 400 


Asp Lys Leu Ala Gln Leu Lys Glu Leu Ile His Arg Gln Ala Ser 
                405                 410                 415 


<210> 5064
<211> 589
<212> PRT
<213> Homo sapiens

<400> 5064
Met Pro Thr Val Ser Val Lys Arg Asp Leu Leu Phe Gln Ala Leu Gly 
1               5                   10                  15      


Arg Thr Tyr Thr Asp Glu Glu Phe Asp Glu Leu Cys Phe Glu Phe Gly 
            20                  25                  30          


Leu Glu Leu Asp Glu Ile Thr Ser Glu Lys Glu Ile Ile Ser Lys Glu 
        35                  40                  45              


Gln Gly Asn Val Lys Ala Ala Gly Ala Ser Asp Val Val Leu Tyr Lys 
    50                  55                  60                  


Ile Asp Val Pro Ala Asn Arg Tyr Asp Leu Leu Cys Leu Glu Gly Leu 
65                  70                  75                  80  


Val Arg Gly Leu Gln Val Phe Lys Glu Arg Ile Lys Ala Pro Val Tyr 
                85                  90                  95      


Lys Arg Val Met Pro Asp Gly Lys Ile Gln Lys Leu Ile Ile Thr Glu 
            100                 105                 110         


Glu Thr Ala Lys Ile Arg Pro Phe Ala Val Ala Ala Val Leu Arg Asn 
        115                 120                 125             


Ile Lys Phe Thr Lys Asp Arg Tyr Asp Ser Phe Ile Glu Leu Gln Glu 
    130                 135                 140                 


Lys Leu His Gln Asn Ile Cys Arg Lys Arg Ala Leu Val Ala Ile Gly 
145                 150                 155                 160 


Thr His Asp Leu Asp Thr Leu Ser Gly Pro Phe Thr Tyr Thr Ala Lys 
                165                 170                 175     


Arg Pro Ser Asp Ile Lys Phe Lys Pro Leu Asn Lys Thr Lys Glu Tyr 
            180                 185                 190         


Thr Ala Cys Glu Leu Met Asn Ile Tyr Lys Thr Asp Asn His Leu Lys 
        195                 200                 205             


His Tyr Leu His Ile Ile Glu Asn Lys Pro Leu Tyr Pro Val Ile Tyr 
    210                 215                 220                 


Asp Ser Asn Gly Val Val Leu Ser Met Pro Pro Ile Ile Asn Gly Asp 
225                 230                 235                 240 


His Ser Arg Ile Thr Val Asn Thr Arg Asn Ile Phe Ile Glu Cys Thr 
                245                 250                 255     


Gly Thr Asp Phe Thr Lys Ala Lys Ile Val Leu Asp Ile Ile Val Thr 
            260                 265                 270         


Met Phe Ser Glu Tyr Cys Glu Asn Gln Phe Thr Val Glu Ala Ala Glu 
        275                 280                 285             


Val Val Phe Pro Asn Gly Lys Ser His Thr Phe Pro Glu Leu Ala Tyr 
    290                 295                 300                 


Arg Lys Glu Met Val Arg Ala Asp Leu Ile Asn Lys Lys Val Gly Ile 
305                 310                 315                 320 


Arg Glu Thr Pro Glu Asn Leu Ala Lys Leu Leu Thr Arg Met Tyr Leu 
                325                 330                 335     


Lys Ser Glu Val Ile Gly Asp Gly Asn Gln Ile Glu Ile Glu Ile Pro 
            340                 345                 350         


Pro Thr Arg Ala Asp Ile Ile His Ala Cys Asp Ile Val Glu Asp Ala 
        355                 360                 365             


Ala Ile Ala Tyr Gly Tyr Asn Asn Ile Gln Met Thr Leu Pro Lys Thr 
    370                 375                 380                 


Tyr Thr Ile Ala Asn Gln Phe Pro Leu Asn Lys Leu Thr Glu Leu Leu 
385                 390                 395                 400 


Arg His Asp Met Ala Ala Ala Gly Phe Thr Glu Ala Leu Thr Phe Ala 
                405                 410                 415     


Leu Cys Ser Gln Glu Asp Ile Ala Asp Lys Leu Gly Val Asp Ile Ser 
            420                 425                 430         


Ala Thr Lys Ala Val His Ile Ser Asn Pro Lys Thr Ala Glu Phe Gln 
        435                 440                 445             


Val Ala Arg Thr Thr Leu Leu Pro Gly Leu Leu Lys Thr Ile Ala Ala 
    450                 455                 460                 


Asn Arg Lys Met Pro Leu Pro Leu Lys Leu Phe Glu Ile Ser Asp Ile 
465                 470                 475                 480 


Val Ile Lys Asp Ser Asn Thr Asp Val Gly Ala Lys Asn Tyr Arg His 
                485                 490                 495     


Leu Cys Ala Val Tyr Tyr Asn Lys Asn Pro Gly Phe Glu Ile Ile His 
            500                 505                 510         


Gly Leu Leu Asp Arg Ile Met Gln Leu Leu Asp Val Pro Pro Gly Glu 
        515                 520                 525             


Asp Lys Gly Gly Tyr Val Ile Lys Ala Ser Glu Gly Pro Ala Phe Phe 
    530                 535                 540                 


Pro Gly Arg Cys Ala Glu Ile Phe Ala Arg Gly Gln Ser Val Gly Lys 
545                 550                 555                 560 


Leu Gly Val Leu His Pro Asp Val Ile Thr Lys Phe Glu Leu Thr Met 
                565                 570                 575     


Pro Cys Ser Ser Leu Glu Ile Asn Val Gly Pro Phe Leu 
            580                 585                 


<210> 5065
<211> 158
<212> PRT
<213> Homo sapiens

<400> 5065
Met Ala Ala Gln Gly Val Gly Pro Gly Pro Gly Ser Ala Ala Pro Pro 
1               5                   10                  15      


Gly Leu Glu Ala Ala Arg Gln Lys Leu Ala Leu Arg Arg Lys Lys Val 
            20                  25                  30          


Leu Ser Thr Glu Glu Met Glu Leu Tyr Glu Leu Ala Gln Ala Ala Gly 
        35                  40                  45              


Gly Ala Ile Asp Pro Asp Val Phe Lys Ile Leu Val Asp Leu Leu Lys 
    50                  55                  60                  


Leu Asn Val Ala Pro Leu Ala Val Phe Gln Met Leu Lys Ser Met Cys 
65                  70                  75                  80  


Ala Gly Gln Arg Leu Ala Ser Glu Pro Gln Asp Pro Ala Ala Val Ser 
                85                  90                  95      


Leu Pro Thr Ser Ser Val Pro Glu Thr Arg Gly Arg Asn Lys Gly Ser 
            100                 105                 110         


Ala Ala Leu Gly Gly Ala Leu Ala Leu Ala Glu Arg Ser Ser Arg Glu 
        115                 120                 125             


Gly Ser Ser Gln Arg Met Pro Arg Gln Pro Ser Ala Thr Arg Leu Pro 
    130                 135                 140                 


Lys Gly Gly Gly Pro Gly Lys Ser Pro Thr Arg Gly Ser Thr 
145                 150                 155             


<210> 5066
<211> 224
<212> PRT
<213> Homo sapiens

<400> 5066
Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu 
        115                 120                 125             


Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu 
    130                 135                 140                 


Glu Ile Arg Lys Ile Tyr Gly Glu Lys Leu Gln Phe Ile Phe Thr Asn 
145                 150                 155                 160 


Ile Asp Pro Lys Asn Pro Glu Ser Pro Phe Met Phe Ser Leu His Leu 
                165                 170                 175     


Asn Glu Ala Arg Asp Tyr Glu Val Ser Asp Ser Ala Pro His Leu Glu 
            180                 185                 190         


Gly Leu Ala Glu Phe Gln Glu Asn Val Arg Lys Thr Asn Asn Phe Ser 
        195                 200                 205             


Ala Phe Leu Ala Asn Val Arg Lys Ala Phe Thr Ala Thr Val Tyr Asn 
    210                 215                 220                 


<210> 5067
<211> 575
<212> PRT
<213> Homo sapiens

<400> 5067
Met Lys Leu Thr Asp Ser Thr Lys Gly Trp Ile Val Trp Ala Ala Leu 
1               5                   10                  15      


Asp Ser Ser Met Arg Gly Met Ser Leu Ser Ala Gly Ser Ser Pro Leu 
            20                  25                  30          


His Ser Pro Lys Ile Thr Pro His Thr Ser Pro Ala Pro Arg Arg Arg 
        35                  40                  45              


Ser His Thr Pro Asn Pro Ala Ser Tyr Met Val Pro Ser Ser Ala Ser 
    50                  55                  60                  


Thr Ser Val Asn Asn Pro Val Ser Gln Thr Pro Ser Ser Gly Gln Val 
65                  70                  75                  80  


Ile Gln Lys Glu Thr Val Gly Gly Thr Thr Tyr Phe Tyr Thr Asp Thr 
                85                  90                  95      


Thr Pro Ala Pro Leu Thr Gly Met Val Phe Pro Asn Tyr His Ile Tyr 
            100                 105                 110         


Pro Pro Thr Ala Pro His Val Ala Tyr Met Gln Pro Lys Ala Asn Ala 
        115                 120                 125             


Pro Ser Phe Phe Met Ala Asp Glu Leu Arg Gln Glu Leu Ile Asn Arg 
    130                 135                 140                 


His Leu Ile Thr Met Ala Gln Ile Asp Gln Ala Asp Met Pro Ala Val 
145                 150                 155                 160 


Pro Thr Glu Val Asp Ser Tyr His Ser Leu Phe Pro Leu Glu Pro Leu 
                165                 170                 175     


Pro Pro Pro Asn Arg Ile Gln Lys Ser Ser Asn Phe Gly Tyr Ile Thr 
            180                 185                 190         


Ser Cys Tyr Lys Ala Val Asn Ser Lys Asp Asp Leu Pro Tyr Cys Leu 
        195                 200                 205             


Arg Arg Ile His Gly Phe Arg Leu Val Asn Thr Lys Cys Met Val Leu 
    210                 215                 220                 


Val Asp Met Trp Lys Lys Ile Gln His Ser Asn Ile Val Thr Leu Arg 
225                 230                 235                 240 


Glu Val Phe Thr Thr Lys Ala Phe Ala Glu Pro Ser Leu Val Phe Ala 
                245                 250                 255     


Tyr Asp Phe His Ala Gly Gly Glu Thr Met Met Ser Arg His Phe Asn 
            260                 265                 270         


Asp Pro Asn Ala Asp Ala Tyr Phe Thr Lys Arg Lys Trp Gly Gln His 
        275                 280                 285             


Glu Gly Pro Leu Pro Arg Gln His Ala Gly Leu Leu Pro Glu Ser Leu 
    290                 295                 300                 


Ile Trp Ala Tyr Ile Val Gln Leu Ser Ser Ala Leu Arg Thr Ile His 
305                 310                 315                 320 


Thr Ala Gly Leu Ala Cys Arg Val Met Asp Pro Thr Lys Ile Leu Ile 
                325                 330                 335     


Thr Gly Lys Thr Arg Leu Arg Val Asn Cys Val Gly Val Phe Asp Val 
            340                 345                 350         


Leu Thr Phe Asp Asn Ser Gln Asn Asn Asn Pro Leu Ala Leu Met Ala 
        355                 360                 365             


Gln Tyr Gln Gln Ala Asp Leu Ile Ser Leu Gly Lys Val Val Leu Ala 
    370                 375                 380                 


Leu Ala Cys Asn Ser Leu Ala Gly Ile Gln Arg Glu Asn Leu Gln Lys 
385                 390                 395                 400 


Ala Met Glu Leu Val Thr Ile Asn Tyr Ser Ser Asp Leu Lys Asn Leu 
                405                 410                 415     


Ile Leu Tyr Leu Leu Thr Asp Gln Asn Arg Met Arg Ser Val Asn Asp 
            420                 425                 430         


Ile Met Pro Met Ile Gly Ala Arg Phe Tyr Thr Gln Leu Asp Ala Ala 
        435                 440                 445             


Gln Met Arg Asn Asp Val Ile Glu Glu Asp Leu Ala Lys Glu Val Gln 
    450                 455                 460                 


Asn Gly Arg Leu Phe Arg Leu Leu Ala Lys Leu Gly Thr Ile Asn Glu 
465                 470                 475                 480 


Arg Pro Glu Phe Gln Lys Asp Pro Thr Trp Ser Glu Thr Gly Asp Arg 
                485                 490                 495     


Tyr Leu Leu Lys Leu Phe Arg Asp His Leu Phe His Gln Val Thr Glu 
            500                 505                 510         


Ala Gly Ala Pro Trp Ile Asp Leu Ser His Ile Ile Ser Cys Leu Asn 
        515                 520                 525             


Lys Leu Asp Ala Gly Val Pro Glu Lys Ile Ser Leu Ile Ser Arg Asp 
    530                 535                 540                 


Glu Lys Ser Val Leu Val Val Thr Tyr Ser Asp Leu Lys Arg Cys Phe 
545                 550                 555                 560 


Glu Asn Thr Phe Gln Glu Leu Ile Ala Ala Ala Asn Gly Gln Leu 
                565                 570                 575 


<210> 5068
<211> 594
<212> PRT
<213> Homo sapiens

<400> 5068
Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys 
1               5                   10                  15      


Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val 
            20                  25                  30          


Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp 
        35                  40                  45              


Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro 
    50                  55                  60                  


Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly 
65                  70                  75                  80  


Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg 
                85                  90                  95      


Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala 
            100                 105                 110         


Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly 
        115                 120                 125             


Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro 
    130                 135                 140                 


Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr 
145                 150                 155                 160 


Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr 
                165                 170                 175     


Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Arg Arg Lys Leu Leu Pro Gly Arg Ile Gln Leu Trp Gly 
        195                 200                 205             


His Gly Ile Ala Val Asp Trp Ala Glu Pro Glu Val Glu Val Asp Glu 
    210                 215                 220                 


Asp Thr Met Ser Ser Val Lys Ile Leu Tyr Val Arg Asn Leu Met Leu 
225                 230                 235                 240 


Ser Thr Ser Glu Glu Met Ile Glu Lys Glu Phe Asn Asn Ile Lys Pro 
                245                 250                 255     


Gly Ala Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His 
            260                 265                 270         


Phe Ser Asn Arg Glu Asp Ala Val Glu Ala Met Lys Ala Leu Asn Gly 
        275                 280                 285             


Lys Val Leu Asp Gly Ser Pro Ile Glu Val Thr Leu Ala Lys Pro Val 
    290                 295                 300                 


Asp Lys Asp Ser Tyr Val Arg Tyr Thr Arg Gly Thr Gly Gly Arg Gly 
305                 310                 315                 320 


Thr Met Leu Gln Gly Glu Tyr Thr Tyr Ser Leu Gly Gln Val Tyr Asp 
                325                 330                 335     


Pro Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe Tyr Ala Pro Gln Thr 
            340                 345                 350         


Tyr Ala Ala Ile Pro Ser Leu His Phe Pro Ala Thr Lys Gly His Leu 
        355                 360                 365             


Ser Asn Arg Ala Ile Ile Arg Ala Pro Ser Val Arg Glu Ile Tyr Met 
    370                 375                 380                 


Asn Val Pro Val Gly Ala Ala Gly Val Arg Gly Leu Gly Gly Arg Gly 
385                 390                 395                 400 


Tyr Leu Ala Tyr Thr Gly Leu Gly Arg Gly Tyr Gln Val Lys Gly Asp 
                405                 410                 415     


Lys Arg Glu Asp Lys Leu Tyr Asp Ile Leu Pro Gly Met Glu Leu Thr 
            420                 425                 430         


Pro Met Asn Pro Val Thr Leu Lys Pro Gln Gly Ile Lys Leu Ala Pro 
        435                 440                 445             


Gln Ile Leu Glu Glu Ile Cys Gln Lys Asn Asn Trp Gly Gln Pro Val 
    450                 455                 460                 


Tyr Gln Leu His Ser Ala Ile Gly Gln Asp Gln Arg Gln Leu Phe Leu 
465                 470                 475                 480 


Tyr Lys Ile Thr Ile Pro Ala Leu Ala Ser Gln Asn Pro Ala Ile His 
                485                 490                 495     


Pro Phe Thr Pro Pro Lys Leu Ser Ala Phe Val Asp Glu Ala Lys Thr 
            500                 505                 510         


Tyr Ala Ala Glu Tyr Thr Leu Gln Thr Leu Gly Ile Pro Thr Asp Gly 
        515                 520                 525             


Gly Asp Gly Thr Met Ala Thr Ala Ala Ala Ala Ala Thr Ala Phe Pro 
    530                 535                 540                 


Gly Tyr Ala Val Pro Asn Ala Thr Ala Pro Val Ser Ala Ala Gln Leu 
545                 550                 555                 560 


Lys Gln Ala Val Thr Leu Gly Gln Asp Leu Ala Ala Tyr Thr Thr Tyr 
                565                 570                 575     


Glu Val Tyr Pro Thr Phe Ala Val Thr Ala Arg Gly Asp Gly Tyr Gly 
            580                 585                 590         


Thr Phe 
        


<210> 5069
<211> 388
<212> PRT
<213> Homo sapiens

<400> 5069
Met Leu Glu Gly Ser Trp Ile Asn Arg Arg Glu Asp Lys Leu Gly Val 
1               5                   10                  15      


Tyr Ser Leu Val His Phe Ser Pro Lys Met Leu Gly Ser Val Ala Thr 
            20                  25                  30          


Thr Leu Pro Leu Ser Ser Ser Asn Ser Ser Gly Met Pro Leu Gly Tyr 
        35                  40                  45              


Tyr Leu Ser Ser Pro Gln Ile Ser Arg Val Thr Ile Ser Thr Thr Gly 
    50                  55                  60                  


Gln Leu Thr Ser Lys Ala Thr Val Gly Ser Cys Ser Arg Val Glu Asn 
65                  70                  75                  80  


Ser Leu Asp Ala Ser Pro Phe Ser Val Pro Lys Lys Gln Asp Glu Ser 
                85                  90                  95      


Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu Ser Leu Phe Gly Asp 
            100                 105                 110         


Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr Gln Lys Thr Leu Lys 
        115                 120                 125             


Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln Phe Thr Ser Ser Ser 
    130                 135                 140                 


Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val Lys Gly Leu Phe Val 
145                 150                 155                 160 


Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met Ala Ile Gly Asp His 
                165                 170                 175     


Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile Ser Leu Tyr Arg Phe 
            180                 185                 190         


Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr Val Thr Val Trp Ala 
        195                 200                 205             


Ala Ala Ser Glu Ala Lys His Gln Pro Pro Ser Asp Phe Leu Trp Lys 
    210                 215                 220                 


Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu Cys 
225                 230                 235                 240 


Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys 
                245                 250                 255     


Gln Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser 
            260                 265                 270         


Val Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser 
        275                 280                 285             


Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile 
    290                 295                 300                 


Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys 
305                 310                 315                 320 


Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn 
                325                 330                 335     


Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn 
            340                 345                 350         


Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser 
        355                 360                 365             


Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu 
    370                 375                 380                 


Ser Gln Lys Gln 
385             


<210> 5070
<211> 247
<212> PRT
<213> Homo sapiens

<400> 5070
Met Glu Glu Gln Pro Gln Met Gln Asp Ala Asp Glu Pro Ala Asp Ser 
1               5                   10                  15      


Gly Gly Glu Gly Arg Ala Gly Gly Pro Pro Gln Val Ala Gly Ala Gln 
            20                  25                  30          


Ala Ala Cys Ser Glu Asp Arg Met Thr Leu Leu Leu Arg Leu Arg Ala 
        35                  40                  45              


Gln Thr Lys Gln Gln Leu Leu Glu Tyr Lys Ser Met Val Asp Ala Ser 
    50                  55                  60                  


Glu Glu Lys Thr Pro Glu Gln Ile Met Gln Glu Lys Gln Ile Glu Ala 
65                  70                  75                  80  


Lys Ile Glu Asp Leu Glu Asn Glu Ile Glu Glu Val Lys Val Ala Phe 
                85                  90                  95      


Glu Ile Lys Lys Leu Ala Leu Asp Arg Met Arg Leu Ser Thr Ala Leu 
            100                 105                 110         


Lys Lys Asn Leu Glu Lys Ile Ser Arg Gln Ser Ser Val Leu Met Asp 
        115                 120                 125             


Asn Met Lys His Leu Leu Glu Leu Asn Lys Leu Ile Met Lys Ser Gln 
    130                 135                 140                 


Gln Glu Ser Trp Asp Leu Glu Glu Lys Leu Leu Asp Ile Arg Lys Lys 
145                 150                 155                 160 


Arg Leu Gln Leu Lys Gln Ala Ser Glu Ser Lys Leu Leu Glu Ile Gln 
                165                 170                 175     


Thr Glu Lys Asn Lys Gln Lys Ile Asp Leu Asp Ser Met Glu Asn Ser 
            180                 185                 190         


Glu Arg Ile Lys Ile Ile Arg Gln Asn Leu Gln Met Glu Ile Lys Ile 
        195                 200                 205             


Thr Thr Val Ile Gln His Val Phe Gln Asn Leu Ile Leu Gly Ser Lys 
    210                 215                 220                 


Val Asn Trp Ala Glu Asp Pro Ala Leu Lys Glu Ile Val Leu Gln Leu 
225                 230                 235                 240 


Glu Lys Asn Val Asp Met Met 
                245         


<210> 5071
<211> 485
<212> PRT
<213> Homo sapiens

<400> 5071
Met Glu Phe Leu Gly Thr Thr Gln Thr Ala Ser Tyr Cys Gly Pro Lys 
1               5                   10                  15      


Lys Cys Cys Gly Leu Thr Ser Leu Pro Ala Val Gln Ala Pro Val Ile 
            20                  25                  30          


Gln Glu Cys Tyr Gln Pro Tyr Tyr Leu Pro Gly Tyr Arg Tyr Leu Asn 
        35                  40                  45              


Ser Trp Arg Pro Ser Leu Phe Tyr Lys Ile Ala Asn Val Gln Thr Cys 
    50                  55                  60                  


Pro Asp Glu Ser Thr Ser Thr Leu Arg Pro Pro Thr Ile Leu Pro Thr 
65                  70                  75                  80  


Leu Arg Ser Ala Leu Phe Ser Arg Tyr Ser Pro His Asp Trp Asp Gln 
                85                  90                  95      


Ser Asn Gln Leu Gln Val Arg Gly Ala Glu Ala Ser Arg Leu Trp Ala 
            100                 105                 110         


Ser Arg Leu Thr Asp Asp Ser Met Arg Leu Leu Gln Asp Lys Asp Gln 
        115                 120                 125             


Leu Thr His Gln Met Gln Glu Gly Thr Cys Arg Asn Leu Gly Gln Arg 
    130                 135                 140                 


Leu Ser Asp Ile Gly Phe Trp Lys Ser Glu Leu Ser Tyr Glu Leu Asp 
145                 150                 155                 160 


Arg Leu Leu Thr Glu Asn Gln Asn Leu Glu Thr Val Lys Arg Arg Leu 
                165                 170                 175     


Glu Cys Ala Ala Asn Glu Val Asn Cys Pro Leu Gln Val Ala Leu Glu 
            180                 185                 190         


Cys Leu Tyr His Arg Glu Lys Arg Ile Gly Ile Asp Leu Val His Asp 
        195                 200                 205             


Asn Val Glu Lys Asn Leu Ile Arg Glu Val Asp Leu Leu Lys Cys Cys 
    210                 215                 220                 


Gln Glu Gln Met Arg Lys Leu Ala Gln Arg Ile Asp Ile Gln Met Arg 
225                 230                 235                 240 


Asp Asn Arg Asp Ala Gln His Val Leu Glu Arg Asp Leu Glu Asp Lys 
                245                 250                 255     


Ser Ser Ala Gln Cys Ile Asp Glu Lys Cys Phe Asn Leu Arg Asn Thr 
            260                 265                 270         


Ser Asp Cys Ile Ser Phe Phe His Gly Met Glu Lys Ile Asp Gly Thr 
        275                 280                 285             


Ile Ser Val Pro Glu Thr Trp Ala Lys Phe Ser Asn Asp Asn Ile Lys 
    290                 295                 300                 


His Ser Gln Asn Met Arg Ala Asn Ser Ile Gln Leu Arg Glu Glu Ala 
305                 310                 315                 320 


Glu His Leu Phe Glu Thr Leu Ser Asp Gln Met Trp Arg Gln Phe Thr 
                325                 330                 335     


Asp Thr Asn Leu Ala Phe Asn Ala Arg Ile Ser Glu Val Thr Asp Val 
            340                 345                 350         


Lys Asn Lys Leu Gln Thr Gln Leu Ala Lys Thr Leu Gln Glu Ile Phe 
        355                 360                 365             


Gln Ala Glu Asn Thr Ile Met Leu Leu Glu Arg Ser Ile Met Ala Lys 
    370                 375                 380                 


Glu Gly Pro Leu Lys Val Ala Gln Thr Arg Leu Glu Cys Arg Thr Arg 
385                 390                 395                 400 


Arg Pro Asn Met Glu Leu Cys Arg Asp Ile Pro Gln Leu Lys Leu Val 
                405                 410                 415     


Asn Glu Val Phe Thr Ile Asp Asp Thr Leu Gln Thr Leu Lys Leu Arg 
            420                 425                 430         


Leu Arg Glu Thr Gln Asp Thr Leu Gln Leu Leu Val Met Thr Lys Cys 
        435                 440                 445             


Arg Leu Glu His Glu Leu Ala Ile Lys Ala Asn Thr Leu Cys Ile Asp 
    450                 455                 460                 


Lys Glu Lys Cys Met Gly Met Arg Lys Thr Phe Pro Cys Thr Pro Arg 
465                 470                 475                 480 


Leu Val Gly His Thr 
                485 


<210> 5072
<211> 278
<212> PRT
<213> Homo sapiens

<400> 5072
Met Gly Lys Ser Ser Glu Trp Cys Glu Arg Ile Ala Gly Ile Gln Lys 
1               5                   10                  15      


Phe Val Leu Glu Lys Trp Thr Lys Lys Ala Lys Pro Glu Asp Thr Leu 
            20                  25                  30          


Asn Leu Cys Gln Leu Leu Asn Asn Asp Leu Ala Ser Thr Val Val Ser 
        35                  40                  45              


Tyr Pro Arg Arg Phe Val Gly Leu Gly Thr Leu Pro Met Gln Ala Pro 
    50                  55                  60                  


Glu Leu Ala Val Lys Glu Met Glu Arg Cys Val Lys Glu Leu Gly Phe 
65                  70                  75                  80  


Pro Gly Val Gln Ile Gly Thr His Val Asn Glu Trp Asp Leu Asn Ala 
                85                  90                  95      


Gln Glu Leu Phe Pro Val Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser 
            100                 105                 110         


Leu Phe Val His Pro Trp Asp Met Gln Met Asp Gly Arg Met Ala Lys 
        115                 120                 125             


Tyr Trp Leu Pro Trp Leu Val Gly Met Pro Ala Glu Thr Thr Ile Ala 
    130                 135                 140                 


Ile Cys Ser Met Ile Met Gly Gly Val Phe Glu Lys Phe Pro Lys Leu 
145                 150                 155                 160 


Lys Val Cys Phe Ala His Gly Gly Gly Ala Phe Pro Phe Thr Val Gly 
                165                 170                 175     


Arg Ile Ser His Gly Phe Ser Met Arg Pro Asp Leu Cys Ala Gln Asp 
            180                 185                 190         


Asn Pro Met Asn Pro Lys Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala 
        195                 200                 205             


Leu Val His Asp Pro Leu Ser Leu Lys Leu Leu Thr Asp Val Ile Gly 
    210                 215                 220                 


Lys Asp Lys Val Ile Leu Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu 
225                 230                 235                 240 


Leu Glu Pro Gly Lys Leu Ile Glu Ser Met Glu Glu Phe Asp Glu Glu 
                245                 250                 255     


Thr Lys Asn Lys Leu Lys Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu 
            260                 265                 270         


Glu Arg Lys Gln Phe Glu 
        275             


<210> 5073
<211> 825
<212> PRT
<213> Homo sapiens

<400> 5073
Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15      


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30          


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45              


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60                  


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80  


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95      


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110         


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125             


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140                 


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160 


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175     


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190         


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205             


Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg 
    210                 215                 220                 


Pro Gly Ala Pro Ala Ala Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly 
225                 230                 235                 240 


Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly 
                245                 250                 255     


Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro 
            260                 265                 270         


Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val 
        275                 280                 285             


Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp 
    290                 295                 300                 


Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp 
305                 310                 315                 320 


Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe 
                325                 330                 335     


Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys 
            340                 345                 350         


Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser 
        355                 360                 365             


Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys 
    370                 375                 380                 


Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe 
385                 390                 395                 400 


Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu 
                405                 410                 415     


Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe 
            420                 425                 430         


Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val 
        435                 440                 445             


Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys 
    450                 455                 460                 


Pro Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro 
465                 470                 475                 480 


Leu Glu Asp Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp 
                485                 490                 495     


Cys Glu Val Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr 
            500                 505                 510         


Trp Val Thr Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu 
        515                 520                 525             


Gly Thr Asn Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys 
    530                 535                 540                 


Gln Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro 
545                 550                 555                 560 


Gln Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn 
                565                 570                 575     


Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys 
            580                 585                 590         


Met Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro 
        595                 600                 605             


Lys Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu 
    610                 615                 620                 


Gly Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe 
625                 630                 635                 640 


Thr Leu Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu 
                645                 650                 655     


Leu Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu 
            660                 665                 670         


Ser Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys 
        675                 680                 685             


Lys Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly 
    690                 695                 700                 


Gly His Arg Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met 
                725                 730                 735     


Pro Gln Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro 
            740                 745                 750         


Tyr Pro Arg Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg 
        755                 760                 765             


Gly Asn Tyr Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln 
    770                 775                 780                 


Asn Phe Arg Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln 
785                 790                 795                 800 


Gly Tyr Asn Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp 
                805                 810                 815     


Ser Gln His Tyr His Gln Gly Tyr Tyr 
            820                 825 


<210> 5074
<211> 314
<212> PRT
<213> Homo sapiens

<400> 5074
Met Gln Asn Val Ile Asn Thr Val Lys Gly Lys Ala Leu Glu Val Ala 
1               5                   10                  15      


Glu Tyr Leu Thr Pro Val Leu Lys Glu Ser Lys Phe Lys Glu Thr Gly 
            20                  25                  30          


Val Ile Thr Pro Glu Glu Phe Val Ala Ala Gly Asp His Leu Val His 
        35                  40                  45              


His Cys Pro Thr Trp Gln Trp Ala Thr Gly Glu Glu Leu Lys Val Lys 
    50                  55                  60                  


Ala Tyr Leu Pro Thr Gly Lys Gln Phe Leu Val Thr Lys Asn Val Pro 
65                  70                  75                  80  


Cys Tyr Lys Arg Cys Lys Gln Met Glu Tyr Ser Asp Glu Leu Glu Ala 
                85                  90                  95      


Ile Ile Glu Glu Asp Asp Gly Asp Gly Gly Trp Val Asp Thr Tyr His 
            100                 105                 110         


Asn Thr Gly Ile Thr Gly Ile Thr Glu Ala Val Lys Glu Ile Thr Leu 
        115                 120                 125             


Glu Asn Lys Asp Asn Ile Arg Leu Gln Asp Cys Ser Ala Leu Cys Glu 
    130                 135                 140                 


Glu Glu Glu Asp Glu Asp Glu Gly Glu Ala Ala Asp Met Glu Glu Tyr 
145                 150                 155                 160 


Glu Glu Ser Gly Leu Leu Glu Thr Asp Glu Ala Thr Leu Asp Thr Arg 
                165                 170                 175     


Lys Ile Val Glu Ala Cys Lys Ala Lys Thr Asp Ala Gly Gly Glu Asp 
            180                 185                 190         


Ala Ile Leu Gln Thr Arg Thr Tyr Asp Leu Tyr Ile Thr Tyr Asp Lys 
        195                 200                 205             


Tyr Tyr Gln Thr Pro Arg Leu Trp Leu Phe Gly Tyr Asp Glu Gln Arg 
    210                 215                 220                 


Gln Pro Leu Thr Val Glu His Met Tyr Glu Asp Ile Ser Gln Asp His 
225                 230                 235                 240 


Val Lys Lys Thr Val Thr Ile Glu Asn His Pro His Leu Pro Pro Pro 
                245                 250                 255     


Pro Met Cys Ser Val His Pro Cys Arg His Ala Glu Val Met Lys Lys 
            260                 265                 270         


Ile Ile Glu Thr Val Ala Glu Gly Gly Gly Glu Leu Gly Val His Met 
        275                 280                 285             


Tyr Leu Leu Ile Phe Leu Lys Phe Val Gln Ala Val Ile Pro Thr Ile 
    290                 295                 300                 


Glu Tyr Asp Tyr Thr Arg His Phe Thr Met 
305                 310                 


<210> 5075
<211> 299
<212> PRT
<213> Homo sapiens

<400> 5075
Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly Thr Gly Ala Gln 
1               5                   10                  15      


Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly Thr Phe Lys Val 
            20                  25                  30          


Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala Lys Glu Leu Arg 
        35                  40                  45              


Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp Asp Gln Val Ile 
    50                  55                  60                  


Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe Ile Val Thr Asn 
65                  70                  75                  80  


Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys Gln Gly Lys Leu 
                85                  90                  95      


Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr Val Val Tyr Ser 
            100                 105                 110         


Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg Leu Ala Ala Ala 
        115                 120                 125             


His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe Arg Asp Ile Gly 
    130                 135                 140                 


Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe Glu Asn Leu Leu 
145                 150                 155                 160 


Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys Ser Tyr Leu Leu 
                165                 170                 175     


Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met Ser Val Ser Asp 
            180                 185                 190         


Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro Glu Lys Tyr Val 
        195                 200                 205             


Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr Ala Glu Glu Tyr 
    210                 215                 220                 


Ala Ala Leu Leu Thr Lys His Thr Arg Lys Val Val His Asp Ala Lys 
225                 230                 235                 240 


Met Thr Pro Glu Asp Tyr Glu Lys Leu Gly Phe Pro Gly Ala Arg Asp 
                245                 250                 255     


Leu Ala Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro Asp Arg Asp Ile 
            260                 265                 270         


Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr Leu Asp Gln Trp 
        275                 280                 285             


Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu 
    290                 295                 


<210> 5076
<211> 856
<212> PRT
<213> Homo sapiens

<400> 5076
Met Asp Ile Ser Lys Gly Leu Pro Gly Met Gln Gly Gly Leu His Ile 
1               5                   10                  15      


Trp Ile Ser Glu Asn Arg Lys Met Val Pro Val Pro Glu Gly Ala Tyr 
            20                  25                  30          


Gly Asn Phe Phe Glu Glu His Cys Tyr Val Ile Leu His Val Pro Gln 
        35                  40                  45              


Ser Pro Lys Ala Thr Gln Gly Ala Ser Ser Asp Leu His Tyr Trp Val 
    50                  55                  60                  


Gly Lys Gln Ala Gly Ala Glu Ala Gln Gly Ala Ala Glu Ala Phe Gln 
65                  70                  75                  80  


Gln Arg Leu Gln Asp Glu Leu Gly Gly Gln Thr Val Leu His Arg Glu 
                85                  90                  95      


Ala Gln Gly His Glu Ser Asp Cys Phe Cys Ser Tyr Phe Arg Pro Gly 
            100                 105                 110         


Ile Ile Tyr Arg Lys Gly Gly Leu Ala Ser Asp Leu Lys His Val Glu 
        115                 120                 125             


Thr Asn Leu Phe Asn Ile Gln Arg Leu Leu His Ile Lys Gly Arg Lys 
    130                 135                 140                 


His Val Ser Ala Thr Glu Val Glu Leu Ser Trp Asn Ser Phe Asn Lys 
145                 150                 155                 160 


Gly Asp Ile Phe Leu Leu Asp Leu Gly Lys Met Met Ile Gln Trp Asn 
                165                 170                 175     


Gly Pro Lys Thr Ser Ile Ser Glu Lys Ala Arg Gly Leu Ala Leu Thr 
            180                 185                 190         


Tyr Ser Leu Arg Asp Arg Glu Arg Gly Gly Gly Arg Ala Gln Ile Gly 
        195                 200                 205             


Val Val Asp Asp Glu Ala Lys Ala Pro Asp Leu Met Gln Ile Met Glu 
    210                 215                 220                 


Ala Val Leu Gly Arg Arg Val Gly Ser Leu Arg Ala Ala Thr Pro Ser 
225                 230                 235                 240 


Lys Asp Ile Asn Gln Leu Gln Lys Ala Asn Val Arg Leu Tyr His Val 
                245                 250                 255     


Tyr Glu Lys Gly Lys Asp Leu Val Val Leu Glu Leu Ala Thr Pro Pro 
            260                 265                 270         


Leu Thr Gln Asp Leu Leu Gln Glu Glu Asp Phe Tyr Ile Leu Asp Gln 
        275                 280                 285             


Gly Gly Phe Lys Ile Tyr Val Trp Gln Gly Arg Met Ser Ser Leu Gln 
    290                 295                 300                 


Glu Arg Lys Ala Ala Phe Ser Arg Ala Val Gly Phe Ile Gln Ala Lys 
305                 310                 315                 320 


Gly Tyr Pro Thr Tyr Thr Asn Val Glu Val Val Asn Asp Gly Ala Glu 
                325                 330                 335     


Ser Ala Ala Phe Lys Gln Leu Phe Arg Thr Trp Ser Glu Lys Arg Arg 
            340                 345                 350         


Arg Asn Gln Lys Leu Gly Gly Arg Asp Lys Ser Ile His Val Lys Leu 
        355                 360                 365             


Asp Val Gly Lys Leu His Thr Gln Pro Lys Leu Ala Ala Gln Leu Arg 
    370                 375                 380                 


Met Val Asp Asp Gly Ser Gly Lys Val Glu Val Trp Cys Ile Gln Asp 
385                 390                 395                 400 


Leu His Arg Gln Pro Val Asp Pro Lys Arg His Gly Gln Leu Cys Ala 
                405                 410                 415     


Gly Asn Cys Tyr Leu Val Leu Tyr Thr Tyr Gln Arg Leu Gly Arg Val 
            420                 425                 430         


Gln Tyr Ile Leu Tyr Leu Trp Gln Gly His Gln Ala Thr Ala Asp Glu 
        435                 440                 445             


Ile Glu Ala Leu Asn Ser Asn Ala Glu Glu Leu Asp Val Met Tyr Gly 
    450                 455                 460                 


Gly Val Leu Val Gln Glu His Val Thr Met Gly Ser Glu Pro Pro His 
465                 470                 475                 480 


Phe Leu Ala Ile Phe Gln Gly Gln Leu Val Ile Phe Gln Glu Arg Ala 
                485                 490                 495     


Gly His His Gly Lys Gly Gln Ser Ala Ser Thr Thr Arg Leu Phe Gln 
            500                 505                 510         


Val Gln Gly Thr Asp Ser His Asn Thr Arg Thr Met Glu Val Pro Ala 
        515                 520                 525             


Arg Ala Ser Ser Leu Asn Ser Ser Asp Ile Phe Leu Leu Val Thr Ala 
    530                 535                 540                 


Ser Val Cys Tyr Leu Trp Phe Gly Lys Gly Cys Asn Gly Asp Gln Arg 
545                 550                 555                 560 


Glu Met Ala Arg Val Val Val Thr Val Ile Ser Arg Lys Asn Glu Glu 
                565                 570                 575     


Thr Val Leu Glu Gly Gln Glu Pro Pro His Phe Trp Glu Ala Leu Gly 
            580                 585                 590         


Gly Arg Ala Pro Tyr Pro Ser Asn Lys Arg Leu Pro Glu Glu Val Pro 
        595                 600                 605             


Ser Phe Gln Pro Arg Leu Phe Glu Cys Ser Ser His Met Gly Cys Leu 
    610                 615                 620                 


Val Leu Ala Glu Val Gly Phe Phe Ser Gln Glu Asp Leu Asp Lys Tyr 
625                 630                 635                 640 


Asp Ile Met Leu Leu Asp Thr Trp Gln Glu Ile Phe Leu Trp Leu Gly 
                645                 650                 655     


Glu Ala Ala Ser Glu Trp Lys Glu Ala Val Ala Trp Gly Gln Glu Tyr 
            660                 665                 670         


Leu Lys Thr His Pro Ala Gly Arg Ser Pro Ala Thr Pro Ile Val Leu 
        675                 680                 685             


Val Lys Gln Gly His Glu Pro Pro Thr Phe Ile Gly Trp Phe Phe Thr 
    690                 695                 700                 


Trp Asp Pro Tyr Lys Trp Thr Ser His Pro Ser His Lys Glu Val Val 
705                 710                 715                 720 


Asp Gly Ser Pro Ala Ala Ala Ser Thr Ile Ser Glu Ile Thr Ala Glu 
                725                 730                 735     


Val Asn Asn Leu Arg Leu Ser Arg Trp Pro Gly Asn Gly Arg Ala Gly 
            740                 745                 750         


Ala Val Ala Leu Gln Ala Leu Lys Gly Ser Gln Asp Ser Ser Glu Asn 
        755                 760                 765             


Asp Leu Val Arg Ser Pro Lys Ser Ala Gly Ser Arg Thr Ser Ser Ser 
    770                 775                 780                 


Val Ser Ser Thr Ser Ala Thr Ile Asn Gly Gly Leu Arg Arg Glu Gln 
785                 790                 795                 800 


Leu Met His Gln Ala Val Glu Asp Leu Pro Glu Gly Val Asp Pro Ala 
                805                 810                 815     


Arg Arg Glu Phe Tyr Leu Ser Asp Ser Asp Phe Gln Asp Ile Phe Gly 
            820                 825                 830         


Lys Ser Lys Glu Glu Phe Tyr Ser Met Ala Thr Trp Arg Gln Arg Gln 
        835                 840                 845             


Glu Lys Lys Gln Leu Gly Phe Phe 
    850                 855     


<210> 5077
<211> 328
<212> PRT
<213> Homo sapiens

<400> 5077
Met Glu Ala Asn Gly Ser Gln Gly Thr Ser Gly Ser Ala Asn Asp Ser 
1               5                   10                  15      


Gln His Asp Pro Gly Lys Met Phe Ile Gly Gly Leu Ser Trp Gln Thr 
            20                  25                  30          


Ser Pro Asp Ser Leu Arg Asp Tyr Phe Ser Lys Phe Gly Glu Ile Arg 
        35                  40                  45              


Glu Cys Met Val Met Arg Asp Pro Thr Thr Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ala Asp Pro Ala Ser Val Asp Lys Val Leu Gly 
65                  70                  75                  80  


Gln Pro His His Glu Leu Asp Ser Lys Thr Ile Asp Pro Lys Val Ala 
                85                  90                  95      


Phe Pro Arg Arg Ala Gln Pro Lys Met Val Thr Arg Thr Lys Lys Ile 
            100                 105                 110         


Phe Val Gly Gly Leu Ser Ala Asn Thr Val Val Glu Asp Val Lys Gln 
        115                 120                 125             


Tyr Phe Glu Gln Phe Gly Lys Val Glu Asp Ala Met Leu Met Phe Asp 
    130                 135                 140                 


Lys Thr Thr Asn Arg His Arg Gly Phe Gly Phe Val Thr Phe Glu Asn 
145                 150                 155                 160 


Glu Asp Val Val Glu Lys Val Cys Glu Ile His Phe His Glu Ile Asn 
                165                 170                 175     


Asn Lys Met Val Glu Cys Lys Lys Ala Gln Pro Lys Glu Val Met Phe 
            180                 185                 190         


Pro Pro Gly Thr Arg Gly Arg Ala Arg Gly Leu Pro Tyr Thr Met Asp 
        195                 200                 205             


Ala Phe Met Leu Gly Met Gly Met Leu Gly Tyr Pro Asn Phe Val Ala 
    210                 215                 220                 


Thr Tyr Gly Arg Gly Tyr Pro Gly Phe Ala Pro Ser Tyr Gly Tyr Gln 
225                 230                 235                 240 


Phe Pro Gly Phe Pro Ala Ala Ala Tyr Gly Pro Val Ala Ala Ala Ala 
                245                 250                 255     


Val Ala Ala Ala Arg Gly Ser Gly Ser Asn Pro Ala Arg Pro Gly Gly 
            260                 265                 270         


Phe Pro Gly Ala Asn Ser Pro Gly Pro Val Ala Asp Leu Tyr Gly Pro 
        275                 280                 285             


Ala Ser Gln Asp Ser Gly Val Gly Asn Tyr Ile Ser Ala Ala Ser Pro 
    290                 295                 300                 


Gln Pro Gly Ser Gly Phe Gly His Gly Ile Ala Gly Pro Leu Ile Ala 
305                 310                 315                 320 


Thr Ala Phe Thr Asn Gly Tyr His 
                325             


<210> 5078
<211> 217
<212> PRT
<213> Homo sapiens

<400> 5078
Met Glu Ser Val Ala Leu Tyr Ser Phe Gln Ala Thr Glu Ser Asp Glu 
1               5                   10                  15      


Leu Ala Phe Asn Lys Gly Asp Thr Leu Lys Ile Leu Asn Met Glu Asp 
            20                  25                  30          


Asp Gln Asn Trp Tyr Lys Ala Glu Leu Arg Gly Val Glu Gly Phe Ile 
        35                  40                  45              


Pro Lys Asn Tyr Ile Arg Val Lys Pro His Pro Trp Tyr Ser Gly Arg 
    50                  55                  60                  


Ile Ser Arg Gln Leu Ala Glu Glu Ile Leu Met Lys Arg Asn His Leu 
65                  70                  75                  80  


Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ser Pro Gly Glu Phe Ser 
                85                  90                  95      


Val Ser Val Asn Tyr Gly Asp Gln Val Gln His Phe Lys Val Leu Arg 
            100                 105                 110         


Glu Ala Ser Gly Lys Tyr Phe Leu Trp Glu Glu Lys Phe Asn Ser Leu 
        115                 120                 125             


Asn Glu Leu Val Asp Phe Tyr Arg Thr Thr Thr Ile Ala Lys Lys Arg 
    130                 135                 140                 


Gln Ile Phe Leu Arg Asp Glu Glu Pro Leu Leu Lys Ser Pro Gly Ala 
145                 150                 155                 160 


Cys Phe Ala Gln Ala Gln Phe Asp Phe Ser Ala Gln Asp Pro Ser Gln 
                165                 170                 175     


Leu Ser Phe Arg Arg Gly Asp Ile Ile Glu Val Leu Glu Arg Pro Asp 
            180                 185                 190         


Pro His Trp Trp Arg Gly Arg Ser Cys Gly Arg Val Gly Phe Phe Pro 
        195                 200                 205             


Arg Ser Tyr Val Gln Pro Val His Leu 
    210                 215         


<210> 5079
<211> 76
<212> PRT
<213> Homo sapiens

<400> 5079
Met Gly Leu Lys Met Ser Cys Leu Lys Gly Phe Gln Met Cys Val Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser His Asp Glu Ala Pro Val Leu Asn Asp Lys His 
            20                  25                  30          


Leu Asp Val Pro Asp Ile Ile Ile Thr Pro Pro Thr Pro Thr Gly Met 
        35                  40                  45              


Met Leu Pro Arg Asp Leu Gly Ser Thr Val Trp Leu Asp Glu Thr Gly 
    50                  55                  60                  


Ser Cys Pro Asp Asp Gly Glu Ile Asp Pro Glu Ala 
65                  70                  75      


<210> 5080
<211> 6620
<212> PRT
<213> Homo sapiens

<400> 5080
Met Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro 
1               5                   10                  15      


Lys Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Cys Gln 
            20                  25                  30          


Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln 
        35                  40                  45              


Pro Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu 
    50                  55                  60                  


Tyr Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr 
65                  70                  75                  80  


Val Cys Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Ala Val Gly 
                85                  90                  95      


Leu Gln Val Asp Ala Glu Ala Ala Cys Ala Glu Gln Ala Pro His Phe 
            100                 105                 110         


Leu Leu Arg Pro Thr Ser Ile Arg Val Arg Glu Gly Ser Glu Ala Thr 
        115                 120                 125             


Phe Arg Cys Arg Val Gly Gly Ser Pro Arg Pro Ala Val Ser Trp Ser 
    130                 135                 140                 


Lys Asp Gly Arg Arg Leu Gly Glu Pro Asp Gly Pro Arg Val Arg Val 
145                 150                 155                 160 


Glu Glu Leu Gly Glu Ala Ser Ala Leu Arg Ile Arg Ala Ala Arg Pro 
                165                 170                 175     


Arg Asp Gly Gly Thr Tyr Glu Val Arg Ala Glu Asn Pro Leu Gly Ala 
            180                 185                 190         


Ala Ser Ala Ala Ala Ala Leu Val Val Asp Ser Asp Ala Ala Asp Thr 
        195                 200                 205             


Ala Ser Arg Pro Gly Thr Ser Thr Ala Ala Leu Leu Ala His Leu Gln 
    210                 215                 220                 


Arg Arg Arg Glu Ala Met Arg Ala Glu Gly Ala Pro Ala Ser Pro Pro 
225                 230                 235                 240 


Ser Thr Gly Thr Arg Thr Cys Thr Val Thr Glu Gly Lys His Ala Arg 
                245                 250                 255     


Leu Ser Cys Tyr Val Thr Gly Glu Pro Lys Pro Glu Thr Val Trp Lys 
            260                 265                 270         


Lys Asp Gly Gln Leu Val Thr Glu Gly Arg Arg His Val Val Tyr Glu 
        275                 280                 285             


Asp Ala Gln Glu Asn Phe Val Leu Lys Ile Leu Phe Cys Lys Gln Ser 
    290                 295                 300                 


Asp Arg Gly Leu Tyr Thr Cys Thr Ala Ser Asn Leu Val Gly Gln Thr 
305                 310                 315                 320 


Tyr Ser Ser Val Leu Val Val Val Arg Glu Pro Ala Val Pro Phe Lys 
                325                 330                 335     


Lys Arg Leu Gln Asp Leu Glu Val Arg Glu Lys Glu Ser Ala Thr Phe 
            340                 345                 350         


Leu Cys Glu Val Pro Gln Pro Ser Thr Glu Ala Ala Trp Phe Lys Glu 
        355                 360                 365             


Glu Thr Arg Leu Trp Ala Ser Ala Lys Tyr Gly Ile Glu Glu Glu Gly 
    370                 375                 380                 


Thr Glu Arg Arg Leu Thr Val Arg Asn Val Ser Ala Asp Asp Asp Ala 
385                 390                 395                 400 


Val Tyr Ile Cys Glu Thr Pro Glu Gly Ser Arg Thr Val Ala Glu Leu 
                405                 410                 415     


Ala Val Gln Gly Asn Leu Leu Arg Lys Leu Pro Arg Lys Thr Ala Val 
            420                 425                 430         


Arg Val Gly Asp Thr Ala Met Phe Cys Val Glu Leu Ala Val Pro Val 
        435                 440                 445             


Gly Pro Val His Trp Leu Arg Asn Gln Glu Glu Val Val Ala Gly Gly 
    450                 455                 460                 


Arg Val Ala Ile Ser Ala Glu Gly Thr Arg His Thr Leu Thr Ile Ser 
465                 470                 475                 480 


Gln Cys Cys Leu Glu Asp Val Gly Gln Val Ala Phe Met Ala Gly Asp 
                485                 490                 495     


Cys Gln Thr Ser Thr Gln Phe Cys Val Ser Ala Pro Arg Lys Pro Pro 
            500                 505                 510         


Leu Gln Pro Pro Val Asp Pro Val Val Lys Ala Arg Met Glu Ser Ser 
        515                 520                 525             


Val Ile Leu Ser Trp Ser Pro Pro Pro His Gly Glu Arg Pro Val Thr 
    530                 535                 540                 


Ile Asp Gly Tyr Leu Val Glu Lys Lys Lys Leu Gly Thr Tyr Thr Trp 
545                 550                 555                 560 


Ile Arg Cys His Glu Ala Glu Trp Val Ala Thr Pro Glu Leu Thr Val 
                565                 570                 575     


Ala Asp Val Ala Glu Glu Gly Asn Phe Gln Phe Arg Val Ser Ala Leu 
            580                 585                 590         


Asn Ser Phe Gly Gln Ser Pro Tyr Leu Glu Phe Pro Gly Thr Val His 
        595                 600                 605             


Leu Ala Pro Lys Leu Ala Val Arg Thr Pro Leu Lys Ala Val Gln Ala 
    610                 615                 620                 


Val Glu Gly Gly Glu Val Thr Phe Ser Val Asp Leu Thr Val Ala Ser 
625                 630                 635                 640 


Ala Gly Glu Trp Phe Leu Asp Gly Gln Ala Leu Lys Ala Ser Ser Val 
                645                 650                 655     


Tyr Glu Ile His Cys Asp Arg Thr Arg His Thr Leu Thr Ile Arg Glu 
            660                 665                 670         


Val Pro Ala Ser Leu His Gly Ala Gln Leu Lys Phe Val Ala Asn Gly 
        675                 680                 685             


Ile Glu Ser Ser Ile Arg Met Glu Val Arg Ala Ala Pro Gly Leu Thr 
    690                 695                 700                 


Ala Asn Lys Pro Pro Ala Ala Ala Ala Arg Glu Val Leu Ala Arg Leu 
705                 710                 715                 720 


His Glu Glu Ala Gln Leu Leu Ala Glu Leu Ser Asp Gln Ala Ala Ala 
                725                 730                 735     


Val Thr Trp Leu Lys Asp Gly Arg Thr Leu Ser Pro Gly Pro Lys Tyr 
            740                 745                 750         


Glu Val Gln Ala Ser Ala Gly Arg Arg Val Leu Leu Val Arg Asp Val 
        755                 760                 765             


Ala Arg Asp Asp Ala Gly Leu Tyr Glu Cys Val Ser Arg Gly Gly Arg 
    770                 775                 780                 


Ile Ala Tyr Gln Leu Ser Val Gln Gly Leu Ala Arg Phe Leu His Lys 
785                 790                 795                 800 


Asp Met Ala Gly Ser Cys Val Asp Ala Val Ala Gly Gly Pro Ala Gln 
                805                 810                 815     


Phe Glu Cys Glu Thr Ser Glu Ala His Val His Val His Trp Tyr Lys 
            820                 825                 830         


Asp Gly Met Glu Leu Gly His Ser Gly Glu Arg Phe Leu Gln Glu Asp 
        835                 840                 845             


Val Gly Thr Arg His Arg Leu Val Ala Ala Thr Val Thr Arg Gln Asp 
    850                 855                 860                 


Glu Gly Thr Tyr Ser Cys Arg Val Gly Glu Asp Ser Val Asp Phe Arg 
865                 870                 875                 880 


Leu Arg Val Ser Glu Pro Lys Val Val Phe Ala Lys Glu Gln Leu Ala 
                885                 890                 895     


Arg Arg Lys Leu Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys 
            900                 905                 910         


Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys 
        915                 920                 925             


Lys Leu Ser Ser Ser Ser Lys Val Cys Met Glu Ala Thr Gly Cys Thr 
    930                 935                 940                 


Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr 
945                 950                 955                 960 


Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu Asp Val Lys 
                965                 970                 975     


Glu Pro Lys Val Val Phe Ala Lys Asp Gln Val Ala His Ser Glu Val 
            980                 985                 990         


Gln Ala Glu Ala Gly Ala Ser Ala  Thr Leu Ser Cys Glu  Val Ala Gln 
        995                 1000                 1005             


Ala Gln  Thr Glu Val Met Trp  Tyr Lys Asp Gly Lys  Lys Leu Ser 
    1010                 1015                 1020             


Ser Ser  Leu Lys Val His Val  Glu Ala Lys Gly Cys  Arg Arg Arg 
    1025                 1030                 1035             


Leu Val  Val Gln Gln Ala Gly  Lys Thr Asp Ala Gly  Asp Tyr Ser 
    1040                 1045                 1050             


Cys Glu  Ala Arg Gly Gln Arg  Val Ser Phe Arg Leu  His Ile Thr 
    1055                 1060                 1065             


Glu Pro  Lys Met Met Phe Ala  Lys Glu Gln Ser Val  His Asn Glu 
    1070                 1075                 1080             


Val Gln  Ala Glu Ala Gly Ala  Ser Ala Met Leu Ser  Cys Glu Val 
    1085                 1090                 1095             


Ala Gln  Ala Gln Thr Glu Val  Thr Trp Tyr Lys Asp  Gly Lys Lys 
    1100                 1105                 1110             


Leu Ser  Ser Ser Ser Lys Val  Gly Met Glu Val Lys  Gly Cys Thr 
    1115                 1120                 1125             


Arg Arg  Leu Val Leu Pro Gln  Ala Gly Lys Ala Asp  Ala Gly Glu 
    1130                 1135                 1140             


Tyr Ser  Cys Glu Ala Gly Gly  Gln Arg Val Ser Phe  His Leu His 
    1145                 1150                 1155             


Ile Thr  Glu Pro Lys Gly Val  Phe Ala Lys Glu Gln  Ser Val His 
    1160                 1165                 1170             


Asn Glu  Val Gln Ala Glu Ala  Gly Thr Thr Ala Met  Leu Ser Cys 
    1175                 1180                 1185             


Glu Val  Ala Gln Pro Gln Thr  Glu Val Thr Trp Tyr  Lys Asp Gly 
    1190                 1195                 1200             


Lys Lys  Leu Ser Ser Ser Ser  Lys Val Arg Met Glu  Val Lys Gly 
    1205                 1210                 1215             


Cys Thr  Arg Arg Leu Val Val  Gln Gln Val Gly Lys  Ala Asp Ala 
    1220                 1225                 1230             


Gly Glu  Tyr Ser Cys Glu Ala  Gly Gly Gln Arg Val  Ser Phe Gln 
    1235                 1240                 1245             


Leu His  Ile Thr Glu Pro Lys  Ala Val Phe Ala Lys  Glu Gln Leu 
    1250                 1255                 1260             


Val His  Asn Glu Val Arg Thr  Glu Ala Gly Ala Ser  Ala Thr Leu 
    1265                 1270                 1275             


Ser Cys  Glu Val Ala Gln Ala  Gln Thr Glu Val Thr  Trp Tyr Lys 
    1280                 1285                 1290             


Asp Gly  Lys Lys Leu Ser Ser  Ser Ser Lys Val Arg  Ile Glu Ala 
    1295                 1300                 1305             


Ala Gly  Cys Met Arg Gln Leu  Val Val Gln Gln Ala  Gly Gln Ala 
    1310                 1315                 1320             


Asp Ala  Gly Glu Tyr Thr Cys  Glu Ala Gly Gly Gln  Arg Leu Ser 
    1325                 1330                 1335             


Phe His  Leu Asp Val Ser Glu  Pro Lys Ala Val Phe  Ala Lys Glu 
    1340                 1345                 1350             


Gln Leu  Ala His Arg Lys Val  Gln Ala Glu Ala Gly  Ala Ile Ala 
    1355                 1360                 1365             


Thr Leu  Ser Cys Glu Val Ala  Gln Ala Gln Thr Glu  Val Thr Trp 
    1370                 1375                 1380             


Tyr Lys  Asp Gly Lys Lys Leu  Ser Ser Ser Ser Lys  Val Arg Met 
    1385                 1390                 1395             


Glu Ala  Val Gly Cys Thr Arg  Arg Leu Val Val Gln  Gln Ala Cys 
    1400                 1405                 1410             


Gln Ala  Asp Thr Gly Glu Tyr  Ser Cys Glu Ala Gly  Gly Gln Arg 
    1415                 1420                 1425             


Leu Ser  Phe Ser Leu Asp Val  Ala Glu Pro Lys Val  Val Phe Ala 
    1430                 1435                 1440             


Lys Glu  Gln Pro Val His Arg  Glu Val Gln Ala Gln  Ala Gly Ala 
    1445                 1450                 1455             


Ser Thr  Thr Leu Ser Cys Glu  Val Ala Gln Ala Gln  Thr Glu Val 
    1460                 1465                 1470             


Met Trp  Tyr Lys Asp Gly Lys  Lys Leu Ser Phe Ser  Ser Lys Val 
    1475                 1480                 1485             


Arg Met  Glu Ala Val Gly Cys  Thr Arg Arg Leu Val  Val Gln Gln 
    1490                 1495                 1500             


Ala Gly  Gln Ala Val Ala Gly  Glu Tyr Ser Cys Glu  Ala Gly Ser 
    1505                 1510                 1515             


Gln Arg  Leu Ser Phe His Leu  His Val Ala Glu Pro  Lys Ala Val 
    1520                 1525                 1530             


Phe Ala  Lys Glu Gln Pro Ala  Ser Arg Glu Val Gln  Ala Glu Ala 
    1535                 1540                 1545             


Gly Thr  Ser Ala Thr Leu Ser  Cys Glu Val Ala Gln  Ala Gln Thr 
    1550                 1555                 1560             


Glu Val  Thr Trp Tyr Lys Asp  Gly Lys Lys Leu Ser  Ser Ser Ser 
    1565                 1570                 1575             


Lys Val  Arg Met Glu Ala Val  Gly Cys Thr Arg Arg  Leu Val Val 
    1580                 1585                 1590             


Gln Glu  Ala Gly Gln Ala Asp  Ala Gly Glu Tyr Ser  Cys Lys Ala 
    1595                 1600                 1605             


Gly Asp  Gln Arg Leu Ser Phe  His Leu His Val Ala  Glu Pro Lys 
    1610                 1615                 1620             


Val Val  Phe Ala Lys Glu Gln  Pro Ala His Arg Glu  Val Gln Ala 
    1625                 1630                 1635             


Glu Ala  Gly Ala Ser Ala Thr  Leu Ser Cys Glu Val  Ala Gln Ala 
    1640                 1645                 1650             


Gln Thr  Glu Val Thr Trp Tyr  Lys Asp Gly Lys Lys  Leu Ser Ser 
    1655                 1660                 1665             


Ser Ser  Lys Val Arg Val Glu  Ala Val Gly Cys Thr  Arg Arg Leu 
    1670                 1675                 1680             


Val Val  Gln Gln Ala Gly Gln  Ala Glu Ala Gly Glu  Tyr Ser Cys 
    1685                 1690                 1695             


Glu Ala  Gly Gly Gln Gln Leu  Ser Phe Arg Leu Gln  Val Ala Glu 
    1700                 1705                 1710             


Leu Glu  Pro Gln Ile Ser Glu  Arg Pro Cys Arg Arg  Glu Pro Leu 
    1715                 1720                 1725             


Val Val  Lys Glu His Glu Asp  Ile Ile Leu Thr Ala  Thr Leu Ala 
    1730                 1735                 1740             


Thr Pro  Ser Ala Ala Thr Val  Thr Trp Leu Lys Asp  Gly Val Glu 
    1745                 1750                 1755             


Ile Arg  Arg Ser Lys Arg His  Glu Thr Ala Ser Gln  Gly Asp Thr 
    1760                 1765                 1770             


His Thr  Leu Thr Val His Gly  Ala Gln Val Leu Asp  Ser Ala Ile 
    1775                 1780                 1785             


Tyr Ser  Cys Arg Val Gly Ala  Glu Gly Gln Asp Phe  Pro Val Gln 
    1790                 1795                 1800             


Val Glu  Glu Val Ala Ala Lys  Phe Cys Arg Leu Leu  Glu Pro Val 
    1805                 1810                 1815             


Cys Gly  Glu Leu Gly Gly Thr  Val Thr Leu Ala Cys  Glu Leu Ser 
    1820                 1825                 1830             


Pro Ala  Cys Ala Glu Val Val  Trp Arg Cys Gly Asn  Thr Gln Leu 
    1835                 1840                 1845             


Arg Val  Gly Lys Arg Phe Gln  Met Val Ala Glu Gly  Pro Val Arg 
    1850                 1855                 1860             


Ser Leu  Thr Val Leu Gly Leu  Arg Ala Glu Asp Ala  Gly Glu Tyr 
    1865                 1870                 1875             


Val Cys  Glu Ser Arg Asp Asp  His Thr Ser Ala Gln  Leu Thr Val 
    1880                 1885                 1890             


Ser Val  Pro Arg Val Val Lys  Phe Met Ser Gly Leu  Ser Thr Val 
    1895                 1900                 1905             


Val Ala  Glu Glu Gly Gly Glu  Ala Thr Phe Gln Cys  Val Val Ser 
    1910                 1915                 1920             


Pro Ser  Asp Val Ala Val Val  Trp Phe Arg Asp Gly  Ala Leu Leu 
    1925                 1930                 1935             


Gln Pro  Ser Glu Lys Phe Ala  Ile Ser Gln Ser Gly  Ala Ser His 
    1940                 1945                 1950             


Ser Leu  Thr Ile Ser Asp Leu  Val Leu Glu Asp Ala  Gly Gln Ile 
    1955                 1960                 1965             


Thr Val  Glu Ala Glu Gly Ala  Ser Ser Ser Ala Ala  Leu Arg Val 
    1970                 1975                 1980             


Arg Glu  Ala Pro Val Leu Phe  Lys Lys Lys Leu Glu  Pro Gln Thr 
    1985                 1990                 1995             


Val Glu  Glu Arg Ser Ser Val  Thr Leu Glu Val Glu  Leu Thr Arg 
    2000                 2005                 2010             


Pro Trp  Pro Glu Leu Arg Trp  Thr Arg Asn Ala Thr  Ala Leu Ala 
    2015                 2020                 2025             


Pro Gly  Lys Asn Val Glu Ile  His Ala Glu Gly Ala  Arg His Arg 
    2030                 2035                 2040             


Leu Val  Leu His Asn Val Gly  Phe Ala Asp Arg Gly  Phe Phe Gly 
    2045                 2050                 2055             


Cys Glu  Thr Pro Asp Asp Lys  Thr Gln Ala Lys Leu  Thr Val Glu 
    2060                 2065                 2070             


Met Arg  Gln Val Arg Leu Val  Arg Gly Leu Gln Ala  Val Glu Ala 
    2075                 2080                 2085             


Arg Glu  Gln Gly Thr Ala Thr  Met Glu Val Gln Leu  Ser His Ala 
    2090                 2095                 2100             


Asp Val  Asp Gly Ser Trp Thr  Arg Asp Gly Leu Arg  Phe Gln Gln 
    2105                 2110                 2115             


Gly Pro  Thr Cys His Leu Ala  Val Arg Gly Pro Met  His Thr Leu 
    2120                 2125                 2130             


Thr Leu  Ser Gly Leu Arg Pro  Glu Asp Ser Gly Leu  Met Val Phe 
    2135                 2140                 2145             


Lys Ala  Glu Gly Val His Thr  Ser Ala Arg Leu Val  Val Thr Glu 
    2150                 2155                 2160             


Leu Pro  Val Ser Phe Ser Arg  Pro Leu Gln Asp Val  Val Thr Thr 
    2165                 2170                 2175             


Glu Lys  Glu Lys Val Thr Leu  Glu Cys Glu Leu Ser  Arg Pro Asn 
    2180                 2185                 2190             


Val Asp  Val Arg Trp Leu Lys  Asp Gly Val Glu Leu  Arg Ala Gly 
    2195                 2200                 2205             


Lys Thr  Met Ala Ile Ala Ala  Gln Gly Ala Cys Arg  Ser Leu Thr 
    2210                 2215                 2220             


Ile Tyr  Arg Cys Glu Phe Ala  Asp Gln Gly Val Tyr  Val Cys Asp 
    2225                 2230                 2235             


Ala His  Asp Ala Gln Ser Ser  Ala Ser Val Lys Val  Gln Gly Arg 
    2240                 2245                 2250             


Thr Tyr  Thr Leu Ile Tyr Arg  Arg Val Leu Ala Glu  Asp Ala Gly 
    2255                 2260                 2265             


Glu Ile  Gln Phe Val Ala Glu  Asn Ala Glu Ser Arg  Ala Gln Leu 
    2270                 2275                 2280             


Arg Val  Lys Glu Leu Pro Val  Thr Leu Val Arg Pro  Leu Arg Asp 
    2285                 2290                 2295             


Lys Ile  Ala Met Glu Lys His  Arg Gly Val Leu Glu  Cys Gln Val 
    2300                 2305                 2310             


Ser Arg  Ala Ser Ala Gln Val  Arg Trp Phe Lys Gly  Ser Gln Glu 
    2315                 2320                 2325             


Leu Gln  Pro Gly Pro Lys Tyr  Glu Leu Val Ser Asp  Gly Leu Tyr 
    2330                 2335                 2340             


Arg Lys  Leu Ile Ile Ser Asp  Val His Ala Glu Asp  Glu Asp Thr 
    2345                 2350                 2355             


Tyr Thr  Cys Asp Ala Gly Asp  Val Lys Thr Ser Ala  Gln Phe Phe 
    2360                 2365                 2370             


Val Glu  Glu Gln Ser Ile Thr  Ile Val Arg Gly Leu  Gln Asp Val 
    2375                 2380                 2385             


Thr Val  Met Glu Pro Ala Pro  Ala Trp Phe Glu Cys  Glu Thr Ser 
    2390                 2395                 2400             


Ile Pro  Ser Val Arg Pro Pro  Lys Trp Leu Leu Gly  Lys Thr Val 
    2405                 2410                 2415             


Leu Gln  Ala Gly Gly Asn Val  Gly Leu Glu Gln Glu  Gly Thr Val 
    2420                 2425                 2430             


His Arg  Leu Met Leu Arg Arg  Thr Cys Ser Thr Met  Thr Gly Pro 
    2435                 2440                 2445             


Val His  Phe Thr Val Gly Lys  Ser Arg Ser Ser Ala  Arg Leu Val 
    2450                 2455                 2460             


Val Ser  Asp Ile Pro Val Val  Leu Thr Arg Pro Leu  Glu Pro Lys 
    2465                 2470                 2475             


Thr Gly  Arg Glu Leu Gln Ser  Val Val Leu Ser Cys  Asp Phe Arg 
    2480                 2485                 2490             


Pro Ala  Pro Lys Ala Val Gln  Trp Tyr Lys Asp Asp  Thr Pro Leu 
    2495                 2500                 2505             


Ser Pro  Ser Glu Lys Phe Lys  Met Ser Leu Glu Gly  Gln Met Ala 
    2510                 2515                 2520             


Glu Leu  Arg Ile Leu Arg Leu  Met Pro Ala Asp Ala  Gly Val Tyr 
    2525                 2530                 2535             


Arg Cys  Gln Ala Gly Ser Ala  His Ser Ser Thr Glu  Val Thr Val 
    2540                 2545                 2550             


Glu Ala  Arg Glu Val Thr Val  Thr Gly Pro Leu Gln  Asp Ala Glu 
    2555                 2560                 2565             


Ala Thr  Glu Glu Gly Trp Ala  Ser Phe Ser Cys Glu  Leu Ser His 
    2570                 2575                 2580             


Glu Asp  Glu Glu Val Glu Trp  Ser Leu Asn Gly Met  Pro Leu Tyr 
    2585                 2590                 2595             


Asn Asp  Ser Phe His Glu Ile  Ser His Lys Gly Arg  Arg His Thr 
    2600                 2605                 2610             


Leu Val  Leu Lys Ser Ile Gln  Arg Ala Asp Ala Gly  Ile Val Arg 
    2615                 2620                 2625             


Ala Ser  Ser Leu Lys Val Ser  Thr Ser Ala Arg Leu  Glu Val Arg 
    2630                 2635                 2640             


Val Lys  Pro Val Val Phe Leu  Lys Ala Leu Asp Asp  Leu Ser Ala 
    2645                 2650                 2655             


Glu Glu  Arg Gly Thr Leu Ala  Leu Gln Cys Glu Val  Ser Asp Pro 
    2660                 2665                 2670             


Glu Ala  His Val Val Trp Arg  Lys Asp Gly Val Gln  Leu Gly Pro 
    2675                 2680                 2685             


Ser Asp  Lys Tyr Asp Phe Leu  His Thr Ala Gly Thr  Arg Gly Leu 
    2690                 2695                 2700             


Val Val  His Asp Val Ser Pro  Glu Asp Ala Gly Leu  Tyr Thr Cys 
    2705                 2710                 2715             


His Val  Gly Ser Glu Glu Thr  Arg Ala Arg Val Arg  Val His Asp 
    2720                 2725                 2730             


Leu His  Val Gly Ile Thr Lys  Arg Leu Lys Thr Met  Glu Val Leu 
    2735                 2740                 2745             


Glu Gly  Glu Ser Cys Ser Phe  Glu Cys Val Leu Ser  His Glu Ser 
    2750                 2755                 2760             


Ala Ser  Asp Pro Ala Met Trp  Thr Val Gly Gly Lys  Thr Val Gly 
    2765                 2770                 2775             


Ser Ser  Ser Arg Phe Gln Ala  Thr Arg Gln Gly Arg  Lys Tyr Ile 
    2780                 2785                 2790             


Leu Val  Val Arg Glu Ala Ala  Pro Ser Asp Ala Gly  Glu Val Val 
    2795                 2800                 2805             


Phe Ser  Val Arg Gly Leu Thr  Ser Lys Ala Ser Leu  Ile Val Arg 
    2810                 2815                 2820             


Glu Arg  Pro Ala Ala Ile Ile  Lys Pro Leu Glu Asp  Gln Trp Val 
    2825                 2830                 2835             


Ala Pro  Gly Glu Asp Val Glu  Leu Arg Cys Glu Leu  Ser Arg Ala 
    2840                 2845                 2850             


Gly Thr  Pro Val His Trp Leu  Lys Asp Arg Lys Ala  Ile Arg Lys 
    2855                 2860                 2865             


Ser Gln  Lys Tyr Asp Val Val  Cys Glu Gly Thr Met  Ala Met Leu 
    2870                 2875                 2880             


Val Ile  Arg Gly Ala Ser Leu  Lys Asp Ala Gly Glu  Tyr Thr Cys 
    2885                 2890                 2895             


Glu Val  Glu Ala Ser Lys Ser  Thr Ala Ser Leu His  Val Glu Glu 
    2900                 2905                 2910             


Lys Ala  Asn Cys Phe Thr Glu  Glu Leu Thr Asn Leu  Gln Val Glu 
    2915                 2920                 2925             


Glu Lys  Gly Thr Ala Val Phe  Thr Cys Lys Thr Glu  His Pro Ala 
    2930                 2935                 2940             


Ala Thr  Val Thr Trp Arg Lys  Gly Leu Leu Glu Leu  Arg Ala Ser 
    2945                 2950                 2955             


Gly Lys  His Gln Pro Ser Gln  Glu Gly Leu Thr Leu  Arg Leu Thr 
    2960                 2965                 2970             


Ile Ser  Ala Leu Glu Lys Ala  Asp Ser Asp Thr Tyr  Thr Cys Asp 
    2975                 2980                 2985             


Ile Gly  Gln Ala Gln Ser Arg  Ala Gln Leu Leu Val  Gln Gly Arg 
    2990                 2995                 3000             


Arg Val  His Ile Ile Glu Asp  Leu Glu Asp Val Asp  Val Gln Glu 
    3005                 3010                 3015             


Gly Ser  Ser Ala Thr Phe Arg  Cys Arg Ile Ser Pro  Ala Asn Tyr 
    3020                 3025                 3030             


Glu Pro  Val His Trp Phe Leu  Asp Lys Thr Pro Leu  His Ala Asn 
    3035                 3040                 3045             


Glu Leu  Asn Glu Ile Asp Ala  Gln Pro Gly Gly Tyr  His Val Leu 
    3050                 3055                 3060             


Thr Leu  Arg Gln Leu Ala Leu  Lys Asp Ser Gly Thr  Ile Tyr Phe 
    3065                 3070                 3075             


Glu Ala  Gly Asp Gln Arg Ala  Ser Ala Ala Leu Arg  Val Thr Glu 
    3080                 3085                 3090             


Lys Pro  Ser Val Phe Ser Arg  Glu Leu Thr Asp Ala  Thr Ile Thr 
    3095                 3100                 3105             


Glu Gly  Glu Asp Leu Thr Leu  Val Cys Glu Thr Ser  Thr Cys Asp 
    3110                 3115                 3120             


Ile Pro  Val Cys Trp Thr Lys  Asp Gly Lys Thr Leu  Arg Gly Ser 
    3125                 3130                 3135             


Ala Arg  Cys Gln Leu Ser His  Glu Gly His Arg Ala  Gln Leu Leu 
    3140                 3145                 3150             


Ile Thr  Gly Ala Thr Leu Gln  Asp Ser Gly Arg Tyr  Lys Cys Glu 
    3155                 3160                 3165             


Ala Gly  Gly Ala Cys Ser Ser  Ser Ile Val Arg Val  His Ala Arg 
    3170                 3175                 3180             


Pro Val  Arg Phe Gln Glu Ala  Leu Lys Asp Leu Glu  Val Leu Glu 
    3185                 3190                 3195             


Gly Gly  Ala Ala Thr Leu Arg  Cys Val Leu Ser Ser  Val Ala Ala 
    3200                 3205                 3210             


Pro Val  Lys Trp Cys Tyr Gly  Asn Asn Val Leu Arg  Pro Gly Asp 
    3215                 3220                 3225             


Lys Tyr  Ser Leu Arg Gln Glu  Gly Ala Met Leu Glu  Leu Val Val 
    3230                 3235                 3240             


Arg Asn  Leu Arg Pro Gln Asp  Ser Gly Arg Tyr Ser  Cys Ser Phe 
    3245                 3250                 3255             


Gly Asp  Gln Thr Thr Ser Ala  Thr Leu Thr Val Thr  Ala Leu Pro 
    3260                 3265                 3270             


Ala Gln  Phe Ile Gly Lys Leu  Arg Asn Lys Glu Ala  Thr Glu Gly 
    3275                 3280                 3285             


Ala Thr  Ala Thr Leu Arg Cys  Glu Leu Ser Lys Ala  Ala Pro Val 
    3290                 3295                 3300             


Glu Trp  Arg Lys Gly Ser Glu  Thr Leu Arg Asp Gly  Asp Arg Tyr 
    3305                 3310                 3315             


Cys Leu  Arg Gln Asp Gly Ala  Met Cys Glu Leu Gln  Ile Arg Gly 
    3320                 3325                 3330             


Leu Ala  Met Val Asp Ala Ala  Glu Tyr Ser Cys Val  Cys Gly Glu 
    3335                 3340                 3345             


Glu Arg  Thr Ser Ala Ser Leu  Thr Ile Arg Pro Met  Pro Ala His 
    3350                 3355                 3360             


Phe Ile  Gly Arg Leu Arg His  Gln Glu Ser Ile Glu  Gly Ala Thr 
    3365                 3370                 3375             


Ala Thr  Leu Arg Cys Glu Leu  Ser Lys Ala Ala Pro  Val Glu Trp 
    3380                 3385                 3390             


Arg Lys  Gly Arg Glu Ser Leu  Arg Asp Gly Asp Arg  His Ser Leu 
    3395                 3400                 3405             


Arg Gln  Asp Gly Ala Val Cys  Glu Leu Gln Ile Cys  Gly Leu Ala 
    3410                 3415                 3420             


Val Ala  Asp Ala Gly Glu Tyr  Ser Cys Val Cys Gly  Glu Glu Arg 
    3425                 3430                 3435             


Thr Ser  Ala Thr Leu Thr Val  Lys Ala Leu Pro Ala  Lys Phe Thr 
    3440                 3445                 3450             


Glu Gly  Leu Arg Asn Glu Glu  Ala Val Glu Gly Ala  Thr Ala Met 
    3455                 3460                 3465             


Leu Trp  Cys Glu Leu Ser Lys  Val Ala Pro Val Glu  Trp Arg Lys 
    3470                 3475                 3480             


Gly Pro  Glu Asn Leu Arg Asp  Gly Asp Arg Tyr Ile  Leu Arg Gln 
    3485                 3490                 3495             


Glu Gly  Thr Arg Cys Glu Leu  Gln Ile Cys Gly Leu  Ala Met Ala 
    3500                 3505                 3510             


Asp Ala  Gly Glu Tyr Leu Cys  Val Cys Gly Gln Glu  Arg Thr Ser 
    3515                 3520                 3525             


Ala Thr  Leu Thr Ile Arg Ala  Leu Pro Ala Arg Phe  Ile Glu Asp 
    3530                 3535                 3540             


Val Lys  Asn Gln Glu Ala Arg  Glu Gly Ala Thr Ala  Val Leu Gln 
    3545                 3550                 3555             


Cys Glu  Leu Asn Ser Ala Ala  Pro Val Glu Trp Arg  Lys Gly Ser 
    3560                 3565                 3570             


Glu Thr  Leu Arg Asp Gly Asp  Arg Tyr Ser Leu Arg  Gln Asp Gly 
    3575                 3580                 3585             


Thr Lys  Cys Glu Leu Gln Ile  Arg Gly Leu Ala Met  Ala Asp Thr 
    3590                 3595                 3600             


Gly Glu  Tyr Ser Cys Val Cys  Gly Gln Glu Arg Thr  Ser Ala Met 
    3605                 3610                 3615             


Leu Thr  Val Arg Ala Leu Pro  Ile Lys Phe Thr Glu  Gly Leu Arg 
    3620                 3625                 3630             


Asn Glu  Glu Ala Thr Glu Gly  Ala Thr Ala Val Leu  Arg Cys Glu 
    3635                 3640                 3645             


Leu Ser  Lys Met Ala Pro Val  Glu Trp Trp Lys Gly  His Glu Thr 
    3650                 3655                 3660             


Leu Arg  Asp Gly Asp Arg His  Ser Leu Arg Gln Asp  Gly Ala Arg 
    3665                 3670                 3675             


Cys Glu  Leu Gln Ile Arg Gly  Leu Val Ala Glu Asp  Ala Gly Glu 
    3680                 3685                 3690             


Tyr Leu  Cys Met Cys Gly Lys  Glu Arg Thr Ser Ala  Met Leu Thr 
    3695                 3700                 3705             


Val Arg  Ala Met Pro Ser Lys  Phe Ile Glu Gly Leu  Arg Asn Glu 
    3710                 3715                 3720             


Glu Ala  Thr Glu Gly Asp Thr  Ala Thr Leu Trp Cys  Glu Leu Ser 
    3725                 3730                 3735             


Lys Ala  Ala Pro Val Glu Trp  Arg Lys Gly His Glu  Thr Leu Arg 
    3740                 3745                 3750             


Asp Gly  Asp Arg His Ser Leu  Arg Gln Asp Gly Ser  Arg Cys Glu 
    3755                 3760                 3765             


Leu Gln  Ile Arg Gly Leu Ala  Val Val Asp Ala Gly  Glu Tyr Ser 
    3770                 3775                 3780             


Cys Val  Cys Gly Gln Glu Arg  Thr Ser Ala Thr Leu  Thr Val Arg 
    3785                 3790                 3795             


Ala Leu  Pro Ala Arg Phe Ile  Glu Asp Val Lys Asn  Gln Glu Ala 
    3800                 3805                 3810             


Arg Glu  Gly Ala Thr Ala Val  Leu Gln Cys Glu Leu  Ser Lys Ala 
    3815                 3820                 3825             


Ala Pro  Val Glu Trp Arg Lys  Gly Ser Glu Thr Leu  Arg Gly Gly 
    3830                 3835                 3840             


Asp Arg  Tyr Ser Leu Arg Gln  Asp Gly Thr Arg Cys  Glu Leu Gln 
    3845                 3850                 3855             


Ile His  Gly Leu Ser Val Ala  Asp Thr Gly Glu Tyr  Ser Cys Val 
    3860                 3865                 3870             


Cys Gly  Gln Glu Arg Thr Ser  Ala Thr Leu Thr Val  Arg Ala Pro 
    3875                 3880                 3885             


Gln Pro  Val Phe Arg Glu Pro  Leu Gln Ser Leu Gln  Ala Glu Glu 
    3890                 3895                 3900             


Gly Ser  Thr Ala Thr Leu Gln  Cys Glu Leu Ser Glu  Pro Thr Ala 
    3905                 3910                 3915             


Thr Val  Val Trp Ser Lys Gly  Gly Leu Gln Leu Gln  Ala Asn Gly 
    3920                 3925                 3930             


Arg Arg  Glu Pro Arg Leu Gln  Gly Cys Thr Ala Glu  Leu Val Leu 
    3935                 3940                 3945             


Gln Asp  Leu Gln Arg Glu Asp  Thr Gly Glu Tyr Thr  Cys Thr Cys 
    3950                 3955                 3960             


Gly Ser  Gln Ala Thr Ser Ala  Thr Leu Thr Val Thr  Ala Ala Pro 
    3965                 3970                 3975             


Val Arg  Phe Leu Arg Glu Leu  Gln His Gln Glu Val  Asp Glu Gly 
    3980                 3985                 3990             


Gly Thr  Ala His Leu Cys Cys  Glu Leu Ser Arg Ala  Gly Ala Ser 
    3995                 4000                 4005             


Val Glu  Trp Arg Lys Gly Ser  Leu Gln Leu Phe Pro  Cys Ala Lys 
    4010                 4015                 4020             


Tyr Gln  Met Val Gln Asp Gly  Ala Ala Ala Glu Leu  Leu Val Arg 
    4025                 4030                 4035             


Gly Val  Glu Gln Glu Asp Ala  Gly Asp Tyr Thr Cys  Asp Thr Gly 
    4040                 4045                 4050             


His Thr  Gln Ser Met Ala Ser  Leu Ser Val Arg Val  Pro Arg Pro 
    4055                 4060                 4065             


Lys Phe  Lys Thr Arg Leu Gln  Ser Leu Glu Gln Glu  Thr Gly Asp 
    4070                 4075                 4080             


Ile Ala  Arg Leu Cys Cys Gln  Leu Ser Asp Ala Glu  Ser Gly Ala 
    4085                 4090                 4095             


Val Val  Gln Trp Leu Lys Glu  Gly Val Glu Leu His  Ala Gly Pro 
    4100                 4105                 4110             


Lys Tyr  Glu Met Arg Ser Gln  Gly Ala Thr Arg Glu  Leu Leu Ile 
    4115                 4120                 4125             


His Gln  Leu Glu Ala Lys Asp  Thr Gly Glu Tyr Ala  Cys Val Thr 
    4130                 4135                 4140             


Gly Gly  Gln Lys Thr Ala Ala  Ser Leu Arg Val Thr  Glu Pro Glu 
    4145                 4150                 4155             


Val Thr  Ile Val Arg Gly Leu  Val Asp Ala Glu Val  Thr Ala Asp 
    4160                 4165                 4170             


Glu Asp  Val Glu Phe Ser Cys  Glu Val Ser Arg Ala  Gly Ala Thr 
    4175                 4180                 4185             


Gly Val  Gln Trp Cys Leu Gln  Gly Leu Pro Leu Gln  Ser Asn Glu 
    4190                 4195                 4200             


Val Thr  Glu Val Ala Val Arg  Asp Gly Arg Ile His  Thr Leu Arg 
    4205                 4210                 4215             


Leu Lys  Gly Val Thr Pro Glu  Asp Ala Gly Thr Val  Ser Phe His 
    4220                 4225                 4230             


Leu Gly  Asn His Ala Ser Ser  Ala Gln Leu Thr Val  Arg Ala Pro 
    4235                 4240                 4245             


Glu Val  Thr Ile Leu Glu Pro  Leu Gln Asp Val Gln  Leu Ser Glu 
    4250                 4255                 4260             


Gly Gln  Asp Ala Ser Phe Gln  Cys Arg Leu Ser Arg  Ala Ser Gly 
    4265                 4270                 4275             


Gln Glu  Ala Arg Trp Ala Leu  Gly Gly Val Pro Leu  Gln Ala Asn 
    4280                 4285                 4290             


Glu Met  Asn Asp Ile Thr Val  Glu Gln Gly Thr Leu  His Leu Leu 
    4295                 4300                 4305             


Thr Leu  His Lys Val Thr Leu  Glu Asp Ala Gly Thr  Val Ser Phe 
    4310                 4315                 4320             


His Val  Gly Thr Cys Ser Ser  Glu Ala Gln Leu Lys  Val Thr Ala 
    4325                 4330                 4335             


Lys Asn  Thr Val Val Arg Gly  Leu Glu Asn Val Glu  Ala Leu Glu 
    4340                 4345                 4350             


Gly Gly  Glu Ala Leu Phe Glu  Cys Gln Leu Ser Gln  Pro Glu Val 
    4355                 4360                 4365             


Ala Ala  His Thr Trp Leu Leu  Asp Asp Glu Pro Val  His Thr Ser 
    4370                 4375                 4380             


Glu Asn  Ala Glu Val Val Phe  Phe Glu Asn Gly Leu  Arg His Leu 
    4385                 4390                 4395             


Leu Leu  Leu Lys Asn Leu Arg  Pro Gln Asp Ser Cys  Arg Val Thr 
    4400                 4405                 4410             


Phe Leu  Ala Gly Asp Met Val  Thr Ser Ala Phe Leu  Thr Val Arg 
    4415                 4420                 4425             


Gly Trp  Arg Leu Glu Ile Leu  Glu Pro Leu Lys Asn  Ala Ala Val 
    4430                 4435                 4440             


Arg Ala  Gly Ala Gln Ala Cys  Phe Thr Cys Thr Leu  Ser Glu Ala 
    4445                 4450                 4455             


Val Pro  Val Gly Glu Ala Ser  Trp Tyr Ile Asn Gly  Ala Ala Val 
    4460                 4465                 4470             


Gln Pro  Asp Asp Ser Asp Trp  Thr Val Thr Ala Asp  Gly Ser His 
    4475                 4480                 4485             


His Ala  Leu Leu Leu Arg Ser  Ala Gln Pro His His  Ala Gly Glu 
    4490                 4495                 4500             


Val Thr  Phe Ala Cys Arg Asp  Ala Val Ala Ser Ala  Arg Leu Thr 
    4505                 4510                 4515             


Val Leu  Gly Leu Pro Asp Pro  Pro Glu Asp Ala Glu  Val Val Ala 
    4520                 4525                 4530             


Arg Ser  Ser His Thr Val Thr  Leu Ser Trp Ala Ala  Pro Met Ser 
    4535                 4540                 4545             


Asp Gly  Gly Gly Gly Leu Cys  Gly Tyr Arg Val Glu  Val Lys Glu 
    4550                 4555                 4560             


Gly Ala  Thr Gly Gln Trp Arg  Leu Cys His Glu Leu  Val Pro Gly 
    4565                 4570                 4575             


Pro Glu  Cys Val Val Asp Gly  Leu Ala Pro Gly Glu  Thr Tyr Arg 
    4580                 4585                 4590             


Phe Arg  Val Ala Ala Val Gly  Pro Val Gly Ala Gly  Glu Pro Val 
    4595                 4600                 4605             


His Leu  Pro Gln Thr Val Arg  Leu Ala Glu Pro Pro  Lys Pro Val 
    4610                 4615                 4620             


Pro Pro  Gln Pro Ser Ala Pro  Glu Ser Arg Gln Val  Ala Ala Gly 
    4625                 4630                 4635             


Glu Asp  Val Ser Leu Glu Leu  Glu Val Val Ala Glu  Ala Gly Glu 
    4640                 4645                 4650             


Val Ile  Trp His Lys Gly Met  Glu Arg Ile Gln Pro  Gly Gly Arg 
    4655                 4660                 4665             


Phe Glu  Val Val Ser Gln Gly  Arg Gln Gln Met Leu  Val Ile Lys 
    4670                 4675                 4680             


Gly Phe  Thr Ala Glu Asp Gln  Gly Glu Tyr His Cys  Gly Leu Ala 
    4685                 4690                 4695             


Gln Gly  Ser Ile Cys Pro Ala  Ala Ala Thr Phe Gln  Val Ala Leu 
    4700                 4705                 4710             


Ser Pro  Ala Ser Val Asp Glu  Ala Pro Gln Pro Ser  Leu Pro Pro 
    4715                 4720                 4725             


Glu Ala  Ala Gln Glu Gly Asp  Leu His Leu Leu Trp  Glu Ala Leu 
    4730                 4735                 4740             


Ala Arg  Lys Arg Arg Met Ser  Arg Glu Pro Thr Leu  Asp Ser Ile 
    4745                 4750                 4755             


Ser Glu  Leu Pro Glu Glu Asp  Gly Arg Ser Gln Arg  Leu Pro Gln 
    4760                 4765                 4770             


Glu Ala  Glu Glu Val Ala Pro  Asp Leu Ser Glu Gly  Tyr Ser Thr 
    4775                 4780                 4785             


Ala Asp  Glu Leu Ala Arg Thr  Gly Asp Ala Asp Leu  Ser His Thr 
    4790                 4795                 4800             


Ser Ser  Asp Asp Glu Ser Arg  Ala Gly Thr Pro Ser  Leu Val Thr 
    4805                 4810                 4815             


Tyr Leu  Lys Lys Ala Gly Arg  Pro Gly Thr Ser Pro  Leu Ala Ser 
    4820                 4825                 4830             


Lys Val  Gly Ala Pro Ala Ala  Pro Ser Val Lys Pro  Gln Gln Gln 
    4835                 4840                 4845             


Gln Glu  Pro Leu Ala Ala Val  Arg Pro Pro Leu Gly  Asp Leu Ser 
    4850                 4855                 4860             


Thr Lys  Asp Leu Gly Asp Pro  Ser Met Asp Lys Ala  Ala Val Lys 
    4865                 4870                 4875             


Ile Gln  Ala Ala Phe Lys Gly  Tyr Lys Val Arg Lys  Glu Met Lys 
    4880                 4885                 4890             


Gln Gln  Glu Gly Pro Met Phe  Ser His Thr Phe Gly  Asp Thr Glu 
    4895                 4900                 4905             


Ala Gln  Val Gly Asp Ala Leu  Arg Leu Glu Cys Val  Val Ala Ser 
    4910                 4915                 4920             


Lys Ala  Asp Val Arg Ala Arg  Trp Leu Lys Asp Gly  Val Glu Leu 
    4925                 4930                 4935             


Thr Asp  Gly Arg His His His  Ile Asp Gln Leu Gly  Asp Gly Thr 
    4940                 4945                 4950             


Cys Ser  Leu Leu Ile Thr Gly  Leu Asp Arg Ala Asp  Ala Gly Cys 
    4955                 4960                 4965             


Tyr Thr  Cys Gln Val Ser Asn  Lys Phe Gly Gln Val  Thr His Ser 
    4970                 4975                 4980             


Ala Cys  Val Val Val Ser Gly  Ser Glu Ser Glu Ala  Glu Ser Ser 
    4985                 4990                 4995             


Ser Gly  Gly Glu Leu Asp Asp  Ala Phe Arg Arg Ala  Ala Arg Arg 
    5000                 5005                 5010             


Leu His  Arg Leu Phe Arg Thr  Lys Ser Pro Ala Glu  Val Ser Asp 
    5015                 5020                 5025             


Glu Glu  Leu Phe Leu Ser Ala  Asp Glu Gly Pro Ala  Glu Pro Glu 
    5030                 5035                 5040             


Glu Pro  Ala Asp Trp Gln Thr  Tyr Arg Glu Asp Glu  His Phe Ile 
    5045                 5050                 5055             


Cys Ile  Arg Phe Glu Ala Leu  Thr Glu Ala Arg Gln  Ala Val Thr 
    5060                 5065                 5070             


Arg Phe  Gln Glu Met Phe Ala  Thr Leu Gly Ile Gly  Val Glu Ile 
    5075                 5080                 5085             


Lys Leu  Val Glu Gln Gly Pro  Arg Arg Val Glu Met  Cys Ile Ser 
    5090                 5095                 5100             


Lys Glu  Thr Pro Ala Pro Val  Val Pro Pro Glu Pro  Leu Pro Ser 
    5105                 5110                 5115             


Leu Leu  Thr Ser Asp Ala Ala  Pro Val Phe Leu Thr  Glu Leu Gln 
    5120                 5125                 5130             


Asn Gln  Glu Val Gln Asp Gly  Tyr Pro Val Ser Phe  Asp Cys Val 
    5135                 5140                 5145             


Val Thr  Gly Gln Pro Met Pro  Ser Val Arg Trp Phe  Lys Asp Gly 
    5150                 5155                 5160             


Lys Leu  Leu Glu Glu Asp Asp  His Tyr Met Ile Asn  Glu Asp Gln 
    5165                 5170                 5175             


Gln Gly  Gly His Gln Leu Ile  Ile Thr Ala Val Val  Pro Ala Asp 
    5180                 5185                 5190             


Met Gly  Val Tyr Arg Cys Leu  Ala Glu Asn Ser Met  Gly Val Ser 
    5195                 5200                 5205             


Ser Thr  Lys Ala Glu Leu Arg  Val Asp Leu Thr Ser  Thr Asp Tyr 
    5210                 5215                 5220             


Asp Thr  Ala Ala Asp Ala Thr  Glu Ser Ser Ser Tyr  Phe Ser Ala 
    5225                 5230                 5235             


Gln Gly  Tyr Leu Ser Ser Arg  Glu Gln Glu Gly Thr  Glu Ser Thr 
    5240                 5245                 5250             


Thr Asp  Glu Gly Gln Leu Pro  Gln Val Val Glu Glu  Leu Arg Asp 
    5255                 5260                 5265             


Leu Gln  Val Ala Pro Gly Thr  Arg Leu Ala Lys Phe  Gln Leu Lys 
    5270                 5275                 5280             


Val Lys  Gly Tyr Pro Ala Pro  Arg Leu Tyr Trp Phe  Lys Asp Gly 
    5285                 5290                 5295             


Gln Pro  Leu Thr Ala Ser Ala  His Ile Arg Met Thr  Asp Lys Lys 
    5300                 5305                 5310             


Ile Leu  His Thr Leu Glu Ile  Ile Ser Val Thr Arg  Glu Asp Ser 
    5315                 5320                 5325             


Gly Gln  Tyr Ala Ala Tyr Ile  Ser Asn Ala Met Gly  Ala Ala Tyr 
    5330                 5335                 5340             


Ser Ser  Ala Arg Leu Leu Val  Arg Gly Pro Asp Glu  Pro Glu Glu 
    5345                 5350                 5355             


Lys Pro  Ala Ser Asp Val His  Glu Gln Leu Val Pro  Pro Arg Met 
    5360                 5365                 5370             


Leu Glu  Arg Phe Thr Pro Lys  Lys Val Lys Lys Gly  Ser Ser Ile 
    5375                 5380                 5385             


Thr Phe  Ser Val Lys Val Glu  Gly Arg Pro Val Pro  Thr Val His 
    5390                 5395                 5400             


Trp Leu  Arg Glu Glu Ala Glu  Arg Gly Val Leu Trp  Ile Gly Pro 
    5405                 5410                 5415             


Asp Thr  Pro Gly Tyr Thr Val  Ala Ser Ser Ala Gln  Gln His Ser 
    5420                 5425                 5430             


Leu Val  Leu Leu Asp Val Gly  Arg Gln His Gln Gly  Thr Tyr Thr 
    5435                 5440                 5445             


Cys Ile  Ala Ser Asn Ala Ala  Gly Gln Ala Leu Cys  Ser Ala Ser 
    5450                 5455                 5460             


Leu His  Val Ser Gly Leu Pro  Lys Val Glu Glu Gln  Glu Lys Val 
    5465                 5470                 5475             


Lys Glu  Ala Leu Ile Ser Thr  Phe Leu Gln Gly Thr  Thr Gln Ala 
    5480                 5485                 5490             


Ile Ser  Ala Gln Gly Leu Glu  Thr Ala Ser Phe Ala  Asp Leu Gly 
    5495                 5500                 5505             


Gly Gln  Arg Lys Glu Glu Pro  Leu Ala Ala Lys Glu  Ala Leu Gly 
    5510                 5515                 5520             


His Leu  Ser Leu Ala Glu Val  Gly Thr Glu Glu Phe  Leu Gln Lys 
    5525                 5530                 5535             


Leu Thr  Ser Gln Ile Thr Glu  Met Val Ser Ala Lys  Ile Thr Gln 
    5540                 5545                 5550             


Ala Lys  Leu Gln Val Pro Gly  Gly Asp Ser Asp Glu  Asp Ser Lys 
    5555                 5560                 5565             


Thr Pro  Ser Ala Ser Pro Arg  His Gly Arg Ser Arg  Pro Ser Ser 
    5570                 5575                 5580             


Ser Ile  Gln Glu Ser Ser Ser  Glu Ser Glu Asp Gly  Asp Ala Arg 
    5585                 5590                 5595             


Gly Glu  Ile Phe Asp Ile Tyr  Val Val Thr Ala Asp  Tyr Leu Pro 
    5600                 5605                 5610             


Leu Gly  Ala Glu Gln Asp Ala  Ile Thr Leu Arg Glu  Gly Gln Tyr 
    5615                 5620                 5625             


Val Glu  Val Leu Asp Ala Ala  His Pro Leu Arg Trp  Leu Val Arg 
    5630                 5635                 5640             


Thr Lys  Pro Thr Lys Ser Ser  Pro Ser Arg Gln Gly  Trp Val Ser 
    5645                 5650                 5655             


Pro Ala  Tyr Leu Asp Arg Arg  Leu Lys Leu Ser Pro  Glu Trp Gly 
    5660                 5665                 5670             


Ala Ala  Glu Ala Pro Glu Phe  Pro Gly Glu Ala Val  Ser Glu Asp 
    5675                 5680                 5685             


Glu Tyr  Lys Ala Arg Leu Ser  Ser Val Ile Gln Glu  Leu Leu Ser 
    5690                 5695                 5700             


Ser Glu  Gln Ala Phe Val Glu  Glu Leu Gln Phe Leu  Gln Ser His 
    5705                 5710                 5715             


His Leu  Gln His Leu Glu Arg  Cys Pro His Val Pro  Ile Ala Val 
    5720                 5725                 5730             


Ala Gly  Gln Lys Ala Val Ile  Phe Arg Asn Val Arg  Asp Ile Gly 
    5735                 5740                 5745             


Arg Phe  His Ser Ser Phe Leu  Gln Glu Leu Gln Gln  Cys Asp Thr 
    5750                 5755                 5760             


Asp Asp  Asp Val Ala Met Cys  Phe Ile Lys Asn Gln  Ala Ala Phe 
    5765                 5770                 5775             


Glu Gln  Tyr Leu Glu Phe Leu  Val Gly Arg Val Gln  Ala Glu Ser 
    5780                 5785                 5790             


Val Val  Val Ser Thr Ala Ile  Gln Glu Phe Tyr Lys  Lys Tyr Ala 
    5795                 5800                 5805             


Glu Glu  Ala Leu Leu Ala Gly  Asp Pro Ser Gln Pro  Pro Pro Pro 
    5810                 5815                 5820             


Pro Leu  Gln His Tyr Leu Glu  Gln Pro Val Glu Arg  Val Gln Arg 
    5825                 5830                 5835             


Tyr Gln  Ala Leu Leu Lys Glu  Leu Ile Arg Asn Lys  Ala Arg Asn 
    5840                 5845                 5850             


Arg Gln  Asn Cys Ala Leu Leu  Glu Gln Ala Tyr Ala  Val Val Ser 
    5855                 5860                 5865             


Ala Leu  Pro Gln Arg Ala Glu  Asn Lys Leu His Val  Ser Leu Met 
    5870                 5875                 5880             


Glu Asn  Tyr Pro Gly Thr Leu  Gln Ala Leu Gly Glu  Pro Ile Arg 
    5885                 5890                 5895             


Gln Gly  His Phe Ile Val Trp  Glu Gly Ala Pro Gly  Ala Arg Met 
    5900                 5905                 5910             


Pro Trp  Lys Gly His Asn Arg  His Val Phe Leu Phe  Arg Asn His 
    5915                 5920                 5925             


Leu Val  Ile Cys Lys Pro Arg  Arg Asp Ser Arg Thr  Asp Thr Val 
    5930                 5935                 5940             


Ser Tyr  Val Phe Arg Asn Met  Met Lys Leu Ser Ser  Ile Asp Leu 
    5945                 5950                 5955             


Asn Asp  Gln Val Glu Gly Asp  Asp Arg Ala Phe Glu  Val Trp Gln 
    5960                 5965                 5970             


Glu Arg  Glu Asp Ser Val Arg  Lys Tyr Leu Leu Gln  Ala Arg Thr 
    5975                 5980                 5985             


Ala Ile  Ile Lys Ser Ser Trp  Val Lys Glu Ile Cys  Gly Ile Gln 
    5990                 5995                 6000             


Gln Arg  Leu Ala Leu Pro Val  Trp Arg Pro Pro Asp  Phe Glu Glu 
    6005                 6010                 6015             


Glu Leu  Ala Asp Cys Thr Ala  Glu Leu Gly Glu Thr  Val Lys Leu 
    6020                 6025                 6030             


Ala Cys  Arg Val Thr Gly Thr  Pro Lys Pro Val Ile  Ser Trp Tyr 
    6035                 6040                 6045             


Lys Asp  Gly Lys Ala Val Gln  Val Asp Pro His His  Ile Leu Ile 
    6050                 6055                 6060             


Glu Asp  Pro Asp Gly Ser Cys  Ala Leu Ile Leu Asp  Ser Leu Thr 
    6065                 6070                 6075             


Gly Val  Asp Ser Gly Gln Tyr  Met Cys Phe Ala Ala  Ser Ala Ala 
    6080                 6085                 6090             


Gly Asn  Cys Ser Thr Leu Gly  Lys Ile Leu Val Gln  Val Pro Pro 
    6095                 6100                 6105             


Arg Phe  Val Asn Lys Val Arg  Ala Ser Pro Phe Val  Glu Gly Glu 
    6110                 6115                 6120             


Asp Ala  Gln Phe Thr Cys Thr  Ile Glu Gly Ala Pro  Tyr Pro Gln 
    6125                 6130                 6135             


Ile Arg  Trp Tyr Lys Asp Gly  Ala Leu Leu Thr Thr  Gly Asn Lys 
    6140                 6145                 6150             


Phe Gln  Thr Leu Ser Glu Pro  Arg Ser Gly Leu Leu  Val Leu Val 
    6155                 6160                 6165             


Ile Arg  Ala Ala Ser Lys Glu  Asp Leu Gly Leu Tyr  Glu Cys Glu 
    6170                 6175                 6180             


Leu Val  Asn Arg Leu Gly Ser  Ala Arg Ala Ser Ala  Glu Leu Arg 
    6185                 6190                 6195             


Ile Gln  Ser Pro Met Leu Gln  Ala Gln Glu Gln Cys  His Arg Glu 
    6200                 6205                 6210             


Gln Leu  Val Ala Ala Val Glu  Val Thr Glu Gln Glu  Thr Lys Val 
    6215                 6220                 6225             


Pro Lys  Lys Thr Val Ile Ile  Glu Glu Thr Ile Thr  Thr Val Val 
    6230                 6235                 6240             


Lys Ser  Pro Arg Gly Gln Arg  Arg Ser Pro Ser Lys  Ser Pro Ser 
    6245                 6250                 6255             


Arg Ser  Pro Ser Arg Cys Ser  Ala Ser Pro Leu Arg  Pro Gly Leu 
    6260                 6265                 6270             


Leu Ala  Pro Asp Leu Leu Tyr  Leu Pro Gly Ala Gly  Gln Pro Arg 
    6275                 6280                 6285             


Arg Pro  Glu Ala Glu Pro Gly  Gln Lys Pro Val Val  Pro Thr Leu 
    6290                 6295                 6300             


Tyr Val  Thr Glu Ala Glu Ala  His Ser Pro Ala Leu  Pro Gly Leu 
    6305                 6310                 6315             


Ser Gly  Pro Gln Pro Lys Trp  Val Glu Val Glu Glu  Thr Ile Glu 
    6320                 6325                 6330             


Val Arg  Val Lys Lys Met Gly  Pro Gln Gly Val Ser  Pro Thr Thr 
    6335                 6340                 6345             


Glu Val  Pro Arg Ser Ser Ser  Gly His Leu Phe Thr  Leu Pro Gly 
    6350                 6355                 6360             


Ala Thr  Pro Gly Gly Asp Pro  Asn Ser Asn Asn Ser  Asn Asn Lys 
    6365                 6370                 6375             


Leu Leu  Ala Gln Glu Ala Trp  Ala Gln Gly Thr Ala  Met Val Gly 
    6380                 6385                 6390             


Val Arg  Glu Pro Leu Val Phe  Arg Val Asp Ala Arg  Gly Ser Val 
    6395                 6400                 6405             


Asp Trp  Ala Ala Ser Gly Met  Gly Ser Leu Glu Glu  Glu Gly Thr 
    6410                 6415                 6420             


Met Glu  Glu Ala Gly Glu Glu  Glu Gly Glu Asp Gly  Asp Ala Phe 
    6425                 6430                 6435             


Val Thr  Glu Glu Ser Gln Asp  Thr His Ser Leu Gly  Asp Arg Asp 
    6440                 6445                 6450             


Pro Lys  Ile Leu Thr His Asn  Gly Arg Met Leu Thr  Leu Ala Asp 
    6455                 6460                 6465             


Leu Glu  Asp Tyr Val Pro Gly  Glu Gly Glu Thr Phe  His Cys Gly 
    6470                 6475                 6480             


Gly Pro  Gly Pro Gly Ala Pro  Asp Asp Pro Pro Cys  Glu Val Ser 
    6485                 6490                 6495             


Val Ile  Gln Arg Glu Ile Gly  Glu Pro Thr Val Gly  Gln Pro Val 
    6500                 6505                 6510             


Leu Leu  Ser Val Gly His Ala  Leu Gly Pro Arg Gly  Pro Leu Gly 
    6515                 6520                 6525             


Leu Phe  Arg Pro Glu Pro Arg  Gly Ala Ser Pro Pro  Gly Pro Gln 
    6530                 6535                 6540             


Val Arg  Ser Leu Glu Gly Thr  Ser Phe Leu Leu Arg  Glu Ala Pro 
    6545                 6550                 6555             


Ala Arg  Pro Val Gly Ser Ala  Pro Trp Thr Gln Ser  Phe Cys Thr 
    6560                 6565                 6570             


Arg Ile  Arg Arg Ser Ala Asp  Ser Gly Gln Ser Ser  Phe Thr Thr 
    6575                 6580                 6585             


Glu Leu  Ser Thr Gln Thr Val  Asn Phe Gly Thr Val  Gly Glu Thr 
    6590                 6595                 6600             


Val Thr  Leu His Ile Cys Pro  Asp Arg Asp Gly Asp  Glu Ala Ala 
    6605                 6610                 6615             


Gln Pro  
    6620 


<210> 5081
<211> 468
<212> PRT
<213> Homo sapiens

<400> 5081
Met Ala Ala Pro Asp Leu Ser Thr Asn Leu Gln Glu Glu Ala Thr Cys 
1               5                   10                  15      


Ala Ile Cys Leu Asp Tyr Phe Thr Asp Pro Val Met Thr Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Glu Cys Ile Arg Arg Cys Trp Gly Gln Pro Glu 
        35                  40                  45              


Gly Pro Tyr Ala Cys Pro Glu Cys Arg Glu Leu Ser Pro Gln Arg Asn 
    50                  55                  60                  


Leu Arg Pro Asn Arg Pro Leu Ala Lys Met Ala Glu Met Ala Arg Arg 
65                  70                  75                  80  


Leu His Pro Pro Ser Pro Val Pro Gln Gly Val Cys Pro Ala His Arg 
                85                  90                  95      


Glu Pro Leu Ala Ala Phe Cys Gly Asp Glu Leu Arg Leu Leu Cys Ala 
            100                 105                 110         


Ala Cys Glu Arg Ser Gly Glu His Trp Ala His Arg Val Arg Pro Leu 
        115                 120                 125             


Gln Asp Ala Ala Glu Asp Leu Lys Ala Lys Leu Glu Lys Ser Leu Glu 
    130                 135                 140                 


His Leu Arg Lys Gln Met Gln Asp Ala Leu Leu Phe Gln Ala Gln Ala 
145                 150                 155                 160 


Asp Glu Thr Cys Val Leu Trp Gln Lys Met Val Glu Ser Gln Arg Gln 
                165                 170                 175     


Asn Val Leu Gly Glu Phe Glu Arg Leu Arg Arg Leu Leu Ala Glu Glu 
            180                 185                 190         


Glu Gln Gln Leu Leu Gln Arg Leu Glu Glu Glu Glu Leu Glu Val Leu 
        195                 200                 205             


Pro Arg Leu Arg Glu Gly Ala Ala His Leu Gly Gln Gln Ser Ala His 
    210                 215                 220                 


Leu Ala Glu Leu Ile Ala Glu Leu Glu Gly Arg Cys Gln Leu Pro Ala 
225                 230                 235                 240 


Leu Gly Leu Leu Gln Asp Ile Lys Asp Ala Leu Arg Arg Val Gln Asp 
                245                 250                 255     


Val Lys Leu Gln Pro Pro Glu Val Val Pro Met Glu Leu Arg Thr Val 
            260                 265                 270         


Cys Arg Val Pro Gly Leu Val Glu Thr Leu Arg Arg Phe Arg Gly Asp 
        275                 280                 285             


Val Thr Leu Asp Pro Asp Thr Ala Asn Pro Glu Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asp Arg Arg Ser Val Gln Arg Gly Asp Leu Arg Gln Ala Leu Pro Asp 
305                 310                 315                 320 


Ser Pro Glu Arg Phe Asp Pro Gly Pro Cys Val Leu Gly Gln Glu Arg 
                325                 330                 335     


Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg Thr 
            340                 345                 350         


Ser Trp Ala Leu Gly Val Cys Arg Glu Asn Val Asn Arg Lys Glu Lys 
        355                 360                 365             


Gly Glu Leu Ser Ala Gly Asn Gly Phe Trp Ile Leu Val Phe Leu Gly 
    370                 375                 380                 


Ser Tyr Tyr Asn Ser Ser Glu Arg Ala Leu Ala Pro Leu Arg Asp Pro 
385                 390                 395                 400 


Pro Arg Arg Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly His Leu Ser 
                405                 410                 415     


Phe Tyr Ser Ala Thr Asp Gly Ser Leu Leu Phe Ile Phe Pro Glu Ile 
            420                 425                 430         


Pro Phe Ser Gly Thr Leu Arg Pro Leu Phe Ser Pro Leu Ser Ser Ser 
        435                 440                 445             


Pro Thr Pro Met Thr Ile Cys Arg Pro Lys Gly Gly Ser Gly Asp Thr 
    450                 455                 460                 


Leu Ala Pro Gln 
465             


<210> 5082
<211> 270
<212> PRT
<213> Homo sapiens

<400> 5082
Met Ser Pro Gly Ser Gly Val Lys Ser Glu Tyr Met Lys Arg Tyr Gln 
1               5                   10                  15      


Glu Pro Arg Trp Glu Glu Tyr Gly Pro Cys Tyr Arg Glu Leu Leu His 
            20                  25                  30          


Tyr Arg Leu Gly Arg Arg Leu Leu Glu Gln Ala His Ala Pro Trp Leu 
        35                  40                  45              


Trp Asp Asp Trp Gly Pro Ala Gly Ser Ser Glu Asp Ser Ala Ser Ser 
    50                  55                  60                  


Glu Ser Ser Gly Ala Gly Gly Pro Ala Pro Arg Cys Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Pro Pro Pro Val Glu Pro Ala Thr Gln Glu Glu Ala Glu Arg Arg 
                85                  90                  95      


Ala Arg Gly Ala Pro Glu Glu Gln Asp Ala Glu Ala Gly Asp Ala Glu 
            100                 105                 110         


Ala Glu Asp Ala Glu Asp Ala Ala Leu Pro Ala Leu Pro Val Lys Asp 
        115                 120                 125             


Val Glu Asp Lys Pro Glu Gln Gln Thr Arg Thr Arg Glu Thr Asp Lys 
    130                 135                 140                 


Ser Pro Thr Ser Thr Glu Pro Arg Gln Gln Pro Ser Ala Leu Phe Ala 
145                 150                 155                 160 


Arg Gly Asn Arg Lys Ala Val Lys Ser Pro Gln Arg Ser Ser Ser Lys 
                165                 170                 175     


Ile Lys Glu Asn Lys His Pro Phe Ala Leu Tyr Gly Trp Gly Glu Lys 
            180                 185                 190         


Gln Thr Asp Thr Gly Ser Gln Lys Thr His Asn Val Cys Ala Ser Ala 
        195                 200                 205             


Pro Val His Glu Ile His Glu Ser Ala Leu Arg Ala Lys Asn Arg Arg 
    210                 215                 220                 


Gln Val Glu Lys Arg Lys Leu Val Ala Gln Arg Gln Arg Ala His Ser 
225                 230                 235                 240 


Val Asp Val Glu Lys Asn Arg Lys Met Lys Ala Ser Ser Ser Glu Asn 
                245                 250                 255     


Pro Trp Met Thr Glu Tyr Met Arg Cys Tyr Ser Ala Arg Ala 
            260                 265                 270 


<210> 5083
<211> 888
<212> PRT
<213> Homo sapiens

<400> 5083
Met Asp Glu Ser Ala Leu Leu Asp Leu Leu Glu Cys Pro Val Cys Leu 
1               5                   10                  15      


Glu Arg Leu Asp Ala Ser Ala Lys Val Leu Pro Cys Gln His Thr Phe 
            20                  25                  30          


Cys Lys Arg Cys Leu Leu Gly Ile Val Gly Ser Arg Asn Glu Leu Arg 
        35                  40                  45              


Cys Pro Glu Cys Arg Thr Leu Val Gly Ser Gly Val Glu Glu Leu Pro 
    50                  55                  60                  


Ser Asn Ile Leu Leu Val Arg Leu Leu Asp Gly Ile Lys Gln Arg Pro 
65                  70                  75                  80  


Trp Lys Pro Gly Pro Gly Gly Gly Ser Gly Thr Asn Cys Thr Asn Ala 
                85                  90                  95      


Leu Arg Ser Gln Ser Ser Thr Val Ala Asn Cys Ser Ser Lys Asp Leu 
            100                 105                 110         


Gln Ser Ser Gln Gly Gly Gln Gln Pro Arg Val Gln Ser Trp Ser Pro 
        115                 120                 125             


Pro Val Arg Gly Ile Pro Gln Leu Pro Cys Ala Lys Ala Leu Tyr Asn 
    130                 135                 140                 


Tyr Glu Gly Lys Glu Pro Gly Asp Leu Lys Phe Ser Lys Gly Asp Ile 
145                 150                 155                 160 


Ile Ile Leu Arg Arg Gln Val Asp Glu Asn Trp Tyr His Gly Glu Val 
                165                 170                 175     


Asn Gly Ile His Gly Phe Phe Pro Thr Asn Phe Val Gln Ile Ile Lys 
            180                 185                 190         


Pro Leu Pro Gln Pro Pro Pro Gln Cys Lys Ala Leu Tyr Asp Phe Glu 
        195                 200                 205             


Val Lys Asp Lys Glu Ala Asp Lys Asp Cys Leu Pro Phe Ala Lys Asp 
    210                 215                 220                 


Asp Val Leu Thr Val Ile Arg Arg Val Asp Glu Asn Trp Ala Glu Gly 
225                 230                 235                 240 


Met Leu Ala Asp Lys Ile Gly Ile Phe Pro Ile Ser Tyr Val Glu Phe 
                245                 250                 255     


Asn Ser Ala Ala Lys Gln Leu Ile Glu Trp Asp Lys Pro Pro Val Pro 
            260                 265                 270         


Gly Val Asp Ala Gly Glu Cys Ser Ser Ala Ala Ala Gln Ser Ser Thr 
        275                 280                 285             


Ala Pro Lys His Ser Asp Thr Lys Lys Asn Thr Lys Lys Arg His Ser 
    290                 295                 300                 


Phe Thr Ser Leu Thr Met Ala Asn Lys Ser Ser Gln Ala Ser Gln Asn 
305                 310                 315                 320 


Arg His Ser Met Glu Ile Ser Pro Pro Val Leu Ile Ser Ser Ser Asn 
                325                 330                 335     


Pro Thr Ala Ala Ala Arg Ile Ser Glu Leu Ser Gly Leu Ser Cys Ser 
            340                 345                 350         


Ala Pro Ser Gln Val His Ile Ser Thr Thr Gly Leu Ile Val Thr Pro 
        355                 360                 365             


Pro Pro Ser Ser Pro Val Thr Thr Gly Pro Ser Phe Thr Phe Pro Ser 
    370                 375                 380                 


Asp Val Pro Tyr Gln Ala Ala Leu Gly Thr Leu Asn Pro Pro Leu Pro 
385                 390                 395                 400 


Pro Pro Pro Leu Leu Ala Ala Thr Val Leu Ala Ser Thr Pro Pro Gly 
                405                 410                 415     


Ala Thr Ala Ala Ala Ala Ala Ala Gly Met Gly Pro Arg Pro Met Ala 
            420                 425                 430         


Gly Ser Thr Asp Gln Ile Ala His Leu Arg Pro Gln Thr Arg Pro Ser 
        435                 440                 445             


Val Tyr Val Ala Ile Tyr Pro Tyr Thr Pro Arg Lys Glu Asp Glu Leu 
    450                 455                 460                 


Glu Leu Arg Lys Gly Glu Met Phe Leu Val Phe Glu Arg Cys Gln Asp 
465                 470                 475                 480 


Gly Trp Phe Lys Gly Thr Ser Met His Thr Ser Lys Ile Gly Val Phe 
                485                 490                 495     


Pro Gly Asn Tyr Val Ala Pro Val Thr Arg Ala Val Thr Asn Ala Ser 
            500                 505                 510         


Gln Ala Lys Val Pro Met Ser Thr Ala Gly Gln Thr Ser Arg Gly Val 
        515                 520                 525             


Thr Met Val Ser Pro Ser Thr Ala Gly Gly Pro Ala Gln Lys Leu Gln 
    530                 535                 540                 


Gly Asn Gly Val Ala Gly Ser Pro Ser Val Val Pro Ala Ala Val Val 
545                 550                 555                 560 


Ser Ala Ala His Ile Gln Thr Ser Pro Gln Ala Lys Val Leu Leu His 
                565                 570                 575     


Met Thr Gly Gln Met Thr Val Asn Gln Ala Arg Asn Ala Val Arg Thr 
            580                 585                 590         


Val Ala Ala His Asn Gln Glu Arg Pro Thr Ala Ala Val Thr Pro Ile 
        595                 600                 605             


Gln Val Gln Asn Ala Ala Gly Leu Ser Pro Ala Ser Val Gly Leu Ser 
    610                 615                 620                 


His His Ser Leu Ala Ser Pro Gln Pro Ala Pro Leu Met Pro Gly Ser 
625                 630                 635                 640 


Ala Thr His Thr Ala Ala Ile Ser Ile Ser Arg Ala Ser Ala Pro Leu 
                645                 650                 655     


Ala Cys Ala Ala Ala Ala Pro Leu Thr Ser Pro Ser Ile Thr Ser Ala 
            660                 665                 670         


Ser Leu Glu Ala Glu Pro Ser Gly Arg Ile Val Thr Val Leu Pro Gly 
        675                 680                 685             


Leu Pro Thr Ser Pro Asp Ser Ala Ser Ser Ala Cys Gly Asn Ser Ser 
    690                 695                 700                 


Ala Thr Lys Pro Asp Lys Asp Ser Lys Lys Glu Lys Lys Gly Leu Leu 
705                 710                 715                 720 


Lys Leu Leu Ser Gly Ala Ser Thr Lys Arg Lys Pro Arg Val Ser Pro 
                725                 730                 735     


Pro Ala Ser Pro Thr Leu Glu Val Glu Leu Gly Ser Ala Glu Leu Pro 
            740                 745                 750         


Leu Gln Gly Ala Val Gly Pro Glu Leu Pro Pro Gly Gly Gly His Gly 
        755                 760                 765             


Arg Ala Gly Ser Cys Pro Val Asp Gly Asp Gly Pro Val Thr Thr Ala 
    770                 775                 780                 


Val Ala Gly Ala Ala Leu Ala Gln Asp Ala Phe His Arg Lys Ala Ser 
785                 790                 795                 800 


Ser Leu Asp Ser Ala Val Pro Ile Ala Pro Pro Pro Arg Gln Ala Cys 
                805                 810                 815     


Ser Ser Leu Gly Pro Val Leu Asn Glu Ser Arg Pro Val Val Cys Glu 
            820                 825                 830         


Arg His Arg Val Val Val Ser Tyr Pro Pro Gln Ser Glu Ala Glu Leu 
        835                 840                 845             


Glu Leu Lys Glu Gly Asp Ile Val Phe Val His Lys Lys Arg Glu Asp 
    850                 855                 860                 


Gly Trp Phe Lys Gly Thr Leu Gln Arg Asn Gly Lys Thr Gly Leu Phe 
865                 870                 875                 880 


Pro Gly Ser Phe Val Glu Asn Ile 
                885             


<210> 5084
<211> 189
<212> PRT
<213> Homo sapiens

<400> 5084
Met Pro Gln Thr Val Ile Leu Pro Gly Pro Ala Pro Trp Gly Phe Arg 
1               5                   10                  15      


Leu Ser Gly Gly Ile Asp Phe Asn Gln Pro Leu Val Ile Thr Arg Ile 
            20                  25                  30          


Thr Pro Gly Ser Lys Ala Ala Ala Ala Asn Leu Cys Pro Gly Asp Val 
        35                  40                  45              


Ile Leu Ala Ile Asp Gly Phe Gly Thr Glu Ser Met Thr His Ala Asp 
    50                  55                  60                  


Ala Gln Asp Arg Ile Lys Ala Ala Ala His Gln Leu Cys Leu Lys Ile 
65                  70                  75                  80  


Asp Arg Gly Glu Thr His Leu Trp Ser Pro Gln Val Ser Glu Asp Gly 
                85                  90                  95      


Lys Ala His Pro Phe Lys Ile Asn Leu Glu Ser Glu Pro Gln Glu Phe 
            100                 105                 110         


Lys Pro Ile Gly Thr Ala His Asn Arg Arg Ala Gln Pro Phe Val Ala 
        115                 120                 125             


Ala Ala Asn Ile Asp Asp Lys Arg Gln Val Val Ser Ala Ser Tyr Asn 
    130                 135                 140                 


Ser Pro Ile Gly Leu Tyr Ser Thr Ser Asn Ile Gln Asp Ala Leu His 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Leu Ile Pro Ser Ser Pro Gln Lys Thr Gly Thr 
                165                 170                 175     


Thr Leu Asn Thr Ser Ile Ile Phe Gly Pro Asn Leu Ser 
            180                 185                 


<210> 5085
<211> 364
<212> PRT
<213> Homo sapiens

<400> 5085
Met Pro Gln Thr Val Ile Leu Pro Gly Pro Ala Pro Trp Gly Phe Arg 
1               5                   10                  15      


Leu Ser Gly Gly Ile Asp Phe Asn Gln Pro Leu Val Ile Thr Arg Ile 
            20                  25                  30          


Thr Pro Gly Ser Lys Ala Ala Ala Ala Asn Leu Cys Pro Gly Asp Val 
        35                  40                  45              


Ile Leu Ala Ile Asp Gly Phe Gly Thr Glu Ser Met Thr His Ala Asp 
    50                  55                  60                  


Ala Gln Asp Arg Ile Lys Ala Ala Ala His Gln Leu Cys Leu Lys Ile 
65                  70                  75                  80  


Asp Arg Gly Glu Thr His Leu Trp Ser Pro Gln Val Ser Glu Asp Gly 
                85                  90                  95      


Lys Ala His Pro Phe Lys Ile Asn Leu Glu Ser Glu Pro Gln Asp Gly 
            100                 105                 110         


Asn Tyr Phe Glu His Lys His Asn Ile Arg Pro Lys Pro Phe Val Ile 
        115                 120                 125             


Pro Gly Arg Ser Ser Gly Cys Ser Thr Pro Ser Gly Ile Asp Cys Gly 
    130                 135                 140                 


Ser Gly Arg Ser Thr Pro Ser Ser Val Ser Thr Val Ser Thr Ile Cys 
145                 150                 155                 160 


Pro Gly Asp Leu Lys Val Ala Ala Lys Leu Ala Pro Asn Ile Pro Leu 
                165                 170                 175     


Glu Met Glu Leu Pro Gly Val Lys Ile Val His Ala Gln Phe Asn Thr 
            180                 185                 190         


Pro Met Gln Leu Tyr Ser Asp Asp Asn Ile Met Glu Thr Leu Gln Gly 
        195                 200                 205             


Gln Val Ser Thr Ala Leu Gly Glu Thr Pro Leu Met Ser Glu Pro Thr 
    210                 215                 220                 


Ala Ser Val Pro Pro Glu Ser Asp Val Tyr Arg Met Leu His Asp Asn 
225                 230                 235                 240 


Arg Asn Glu Pro Thr Gln Pro Arg Gln Ser Gly Ser Phe Arg Val Leu 
                245                 250                 255     


Gln Gly Met Val Asp Asp Gly Ser Asp Asp Arg Pro Ala Gly Thr Arg 
            260                 265                 270         


Ser Val Arg Ala Pro Val Thr Lys Val His Gly Gly Ser Gly Gly Ala 
        275                 280                 285             


Gln Arg Met Pro Leu Cys Asp Lys Cys Gly Ser Gly Ile Val Gly Ala 
    290                 295                 300                 


Val Val Lys Ala Arg Asp Lys Tyr Arg His Pro Glu Cys Phe Val Cys 
305                 310                 315                 320 


Ala Asp Cys Asn Leu Asn Leu Lys Gln Lys Gly Tyr Phe Phe Ile Glu 
                325                 330                 335     


Gly Glu Leu Tyr Cys Glu Thr His Ala Arg Ala Arg Thr Lys Pro Pro 
            340                 345                 350         


Glu Gly Tyr Asp Thr Val Thr Leu Tyr Pro Lys Ala 
        355                 360                 


<210> 5086
<211> 316
<212> PRT
<213> Homo sapiens

<400> 5086
Met Pro Gln Thr Val Ile Leu Pro Gly Pro Ala Pro Trp Gly Phe Arg 
1               5                   10                  15      


Leu Ser Gly Gly Ile Asp Phe Asn Gln Pro Leu Val Ile Thr Arg Ile 
            20                  25                  30          


Thr Pro Gly Ser Lys Ala Ala Ala Ala Asn Leu Cys Pro Gly Asp Val 
        35                  40                  45              


Ile Leu Ala Ile Asp Gly Phe Gly Thr Glu Ser Met Thr His Ala Asp 
    50                  55                  60                  


Ala Gln Asp Arg Ile Lys Ala Ala Ala His Gln Leu Cys Leu Lys Ile 
65                  70                  75                  80  


Asp Arg Gly Glu Thr His Leu Trp Ser Pro Gln Val Ser Glu Asp Gly 
                85                  90                  95      


Lys Ala His Pro Phe Lys Ile Asn Leu Glu Ser Glu Pro Gln Glu Phe 
            100                 105                 110         


Lys Pro Ile Gly Thr Ala His Asn Arg Arg Ala Gln Pro Phe Val Ala 
        115                 120                 125             


Ala Ala Asn Ile Asp Asp Lys Arg Gln Val Val Ser Ala Ser Tyr Asn 
    130                 135                 140                 


Ser Pro Ile Gly Leu Tyr Ser Thr Ser Asn Ile Gln Asp Ala Leu His 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Leu Ile Pro Ser Ser Pro Gln Asn Glu Pro Thr 
                165                 170                 175     


Ala Ser Val Pro Pro Glu Ser Asp Val Tyr Arg Met Leu His Asp Asn 
            180                 185                 190         


Arg Asn Glu Pro Thr Gln Pro Arg Gln Ser Gly Ser Phe Arg Val Leu 
        195                 200                 205             


Gln Gly Met Val Asp Asp Gly Ser Asp Asp Arg Pro Ala Gly Thr Arg 
    210                 215                 220                 


Ser Val Arg Ala Pro Val Thr Lys Val His Gly Gly Ser Gly Gly Ala 
225                 230                 235                 240 


Gln Arg Met Pro Leu Cys Asp Lys Cys Gly Ser Gly Ile Val Gly Ala 
                245                 250                 255     


Val Val Lys Ala Arg Asp Lys Tyr Arg His Pro Glu Cys Phe Val Cys 
            260                 265                 270         


Ala Asp Cys Asn Leu Asn Leu Lys Gln Lys Gly Tyr Phe Phe Ile Glu 
        275                 280                 285             


Gly Glu Leu Tyr Cys Glu Thr His Ala Arg Ala Arg Thr Lys Pro Pro 
    290                 295                 300                 


Glu Gly Tyr Asp Thr Val Thr Leu Tyr Pro Lys Ala 
305                 310                 315     


<210> 5087
<211> 1100
<212> PRT
<213> Homo sapiens

<400> 5087
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp 
                85                  90                  95      


Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Asp 
            100                 105                 110         


Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn Ala Gly Leu 
        115                 120                 125             


Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln 
    130                 135                 140                 


Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala 
145                 150                 155                 160 


Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro 
                165                 170                 175     


Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp 
            180                 185                 190         


Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu 
        195                 200                 205             


Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln 
    210                 215                 220                 


His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu 
225                 230                 235                 240 


Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg 
                245                 250                 255     


Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln 
            260                 265                 270         


Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser 
        275                 280                 285             


Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser 
    290                 295                 300                 


Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro Ser Leu Cys Ser 
305                 310                 315                 320 


Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu Asp Tyr Cys Ser 
                325                 330                 335     


Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser Pro Arg Ala Ile 
            340                 345                 350         


Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp 
        355                 360                 365             


Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys Ser Arg Ser Cys 
    370                 375                 380                 


Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro Asp Pro Lys Val 
385                 390                 395                 400 


Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu Asp Ser Lys Glu 
                405                 410                 415     


Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro Glu Val Arg Ser 
            420                 425                 430         


Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg Asn Ala Pro Gly 
        435                 440                 445             


Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu 
    450                 455                 460                 


Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr 
465                 470                 475                 480 


Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala Trp Ser Gln Cys 
                485                 490                 495     


Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr Arg Ile Ser Glu 
            500                 505                 510         


Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp 
        515                 520                 525             


Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys 
    530                 535                 540                 


Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu Glu Glu Asn Gln 
545                 550                 555                 560 


Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln Ser Asn Ala Leu 
                565                 570                 575     


Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Ala His 
            580                 585                 590         


Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser 
        595                 600                 605             


Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser Glu Ser Asp Phe 
    610                 615                 620                 


Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His 
625                 630                 635                 640 


His His His His His His His His His His Arg His Leu Ile Ser Ser 
                645                 650                 655     


Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu 
            660                 665                 670         


Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu Pro Arg Arg Gln 
        675                 680                 685             


Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val 
    690                 695                 700                 


Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys Gln Thr Glu Lys 
705                 710                 715                 720 


Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp Ser Ala Leu Lys 
                725                 730                 735     


Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg Gly Ser Leu Pro 
            740                 745                 750         


Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Asp Val 
        755                 760                 765             


Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg Ser Pro Leu His 
    770                 775                 780                 


Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile His Cys Pro Pro 
785                 790                 795                 800 


Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala Ser Phe Gln Asp 
                805                 810                 815     


Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp Arg Gly Gly Ala 
            820                 825                 830         


Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp 
        835                 840                 845             


Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu 
    850                 855                 860                 


Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
865                 870                 875                 880 


Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
                885                 890                 895     


Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
            900                 905                 910         


Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
        915                 920                 925             


Ala Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile 
    930                 935                 940                 


Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
945                 950                 955                 960 


Lys Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
                965                 970                 975     


Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
            980                 985                 990         


Tyr Val Glu Val Val Lys Lys Asn  Thr Lys Gly Ala Glu  Asp Tyr Pro 
        995                 1000                 1005             


Asp Pro  Pro Ile Pro His Ser  Tyr Ser Ser Asp Arg  Ile His Ser 
    1010                 1015                 1020             


Leu Ser  Ser Asn Lys Pro Gln  Arg Pro Val Phe Thr  His Glu Asn 
    1025                 1030                 1035             


Ile Gln  Gly Gly Gly Glu Pro  Phe Gln Ala Leu Tyr  Asn Tyr Thr 
    1040                 1045                 1050             


Pro Arg  Asn Glu Asp Glu Leu  Glu Leu Arg Glu Ser  Asp Val Ile 
    1055                 1060                 1065             


Asp Val  Met Glu Lys Cys Asp  Asp Gly Trp Phe Val  Gly Thr Ser 
    1070                 1075                 1080             


Arg Arg  Thr Lys Phe Phe Gly  Thr Phe Pro Gly Asn  Tyr Val Lys 
    1085                 1090                 1095             


Arg Leu  
    1100 


<210> 5088
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 5088
Met Phe Arg Gly Pro Lys Pro Pro Ile Ala Pro Lys Pro Arg Leu Thr 
1               5                   10                  15      


Ala Pro Asn Glu Trp Arg Ala Ser Val Tyr Leu Asn Asp Ser Leu Asn 
            20                  25                  30          


Lys Cys Ser Asn Gly Arg Leu Pro Cys Val Asp Arg Gly Leu Asp Glu 
        35                  40                  45              


Gly Pro Arg Ser Ile Pro Lys Cys Ser Glu Ser Glu Thr Asp Glu Asp 
    50                  55                  60                  


Tyr Ile Val Val Pro Arg Val Pro Leu Arg Glu Asp Glu Pro Lys Asp 
65                  70                  75                  80  


Glu Gly Ser Val Gly Asn Lys Ala Leu Val Ser Pro Glu Ser Ser Ala 
                85                  90                  95      


Glu Glu Glu Glu Glu Arg Glu Glu Gly Gly Glu Ala Cys Gly Leu Glu 
            100                 105                 110         


Gly Thr Gly Ala Gly Glu Asp Ser Val Ala Pro Ala Ala Pro Gly Ala 
        115                 120                 125             


Gly Ala Leu Ser Arg Glu Gly Glu Glu Gly Thr Asp Leu Ala Leu Glu 
    130                 135                 140                 


Asp Glu Gly Glu Gly Cys Ala Asp Glu Pro Gly Thr Leu Glu Gln Val 
145                 150                 155                 160 


Ser Arg Ser Glu Glu Glu Glu Lys Leu Val Gln Pro His Arg Glu Cys 
                165                 170                 175     


Ser Leu Glu Asp Ser Gly Pro Trp Ala Gly Glu Gly Val Phe Gln Ser 
            180                 185                 190         


Asp Leu Leu Leu Pro His Ile His Gly Glu Asp Gln Glu Pro Pro Asp 
        195                 200                 205             


Thr Pro Gly Glu Ala Glu Glu Asp Asp Glu Glu Gly Cys Ala Ser Thr 
    210                 215                 220                 


Asp Pro Ala Gly Ala Asp Glu Gly Ser Gly Pro Asp Arg Pro Thr Glu 
225                 230                 235                 240 


Asp Met Gly Gln Asp Ala Glu Asp Thr Ser Glu Glu Pro Pro Glu Lys 
                245                 250                 255     


Glu Glu Leu Ala Gly Val Gln Glu Ala Glu Thr Ala Thr Asp Cys Pro 
            260                 265                 270         


Glu Val Leu Glu Glu Gly Cys Glu Glu Ala Thr Gly Val Thr Gly Gly 
        275                 280                 285             


Glu Gln Val Asp Leu Ser Glu Pro Pro Asp His Glu Lys Lys Thr Asn 
    290                 295                 300                 


Gln Glu Val Ala Ala Ala Thr Leu Glu Asp His Ala Gln Asp Glu Ser 
305                 310                 315                 320 


Ala Glu Glu Ser Cys Gln Ile Val Pro Phe Glu Asn Asp Cys Met Glu 
                325                 330                 335     


Asp Phe Val Thr Ser Leu Thr Gly Ser Pro Tyr Glu Phe Phe Pro Thr 
            340                 345                 350         


Glu Ser Thr Ser Phe Cys Ser Glu Ser Cys Ser Pro Leu Ser Glu Ser 
        355                 360                 365             


Ala Lys Gly Leu Glu Ser Glu Gln Ala Pro Lys Leu Gly Leu Arg Ala 
    370                 375                 380                 


Glu Glu Asn Pro Met Val Gly Ala Leu Cys Gly Gln Cys Gly Ser Leu 
385                 390                 395                 400 


Gln Gly Gly Ala Ala Glu Gly Pro Ala Ala Pro Asp Val Val Val Val 
                405                 410                 415     


Leu Glu Glu Glu Ala Leu Asp Asp Ala Leu Ala Asn Pro Tyr Val Met 
            420                 425                 430         


Gly Val Gly Leu Pro Gly Gln Ala Ala Pro Gly Glu Gly Gly Gln Ala 
        435                 440                 445             


Ala Ser Asp Ala Leu Gly Gly Tyr Gly Ser Lys Glu Glu Leu Asn Cys 
    450                 455                 460                 


Glu Ala Glu Gly Gly Leu Val Pro Ala Asp Arg Lys Asn Thr Ser Thr 
465                 470                 475                 480 


Arg Val Arg Pro His Ser Gly Lys Val Ala Gly Tyr Val Pro Glu Thr 
                485                 490                 495     


Val Pro Glu Glu Thr Gly Pro Glu Ala Gly Ser Ser Ala Pro Gly Ile 
            500                 505                 510         


Gly Gly Ala Ala Glu Glu Val Gly Lys Thr Leu Leu Ser Leu Glu Gly 
        515                 520                 525             


Lys Pro Leu Glu Ala Ser Arg Ala Leu Pro Ala Lys Pro Arg Ala Phe 
    530                 535                 540                 


Thr Leu Tyr Pro Arg Ser Phe Ser Val Glu Gly Arg Glu Ile Pro Val 
545                 550                 555                 560 


Ser Val Tyr Gln Glu Pro Glu Gly Ser Gly Leu Asp Asp His Arg Ile 
                565                 570                 575     


Lys Arg Lys Glu Asp Asn Leu Ser Leu Ser Cys Val Ile Gly Ser Ser 
            580                 585                 590         


Gly Ser Phe Ser Gln Arg Asn His Leu Pro Ser Ser Gly Thr Ser Thr 
        595                 600                 605             


Pro Ser Ser Met Val Asp Ile Pro Pro Pro Phe Asp Leu Ala Cys Ile 
    610                 615                 620                 


Thr Lys Lys Pro Ile Thr Lys Ser Ser Pro Ser Leu Leu Ile Glu Ser 
625                 630                 635                 640 


Asp Ser Pro Asp Lys Tyr Lys Lys Lys Lys Ser Ser Phe Lys Arg Phe 
                645                 650                 655     


Leu Ala Leu Thr Phe Lys Lys Lys Thr Glu Asn Lys Leu His Val Asp 
            660                 665                 670         


Val Asn Val Ser Ser Ser Arg Ser Ser Ser Glu Ser Ser Tyr His Gly 
        675                 680                 685             


Pro Ser Arg Ile Leu Glu Val Asp Arg Arg Ser Leu Ser Asn Ser Pro 
    690                 695                 700                 


Gln Leu Lys Ser Arg Thr Gly Lys Leu Arg Ala Ser Glu Ser Pro Ser 
705                 710                 715                 720 


Ser Leu Ile Phe Tyr Arg Asp Gly Lys Arg Lys Gly Val Pro Phe Ser 
                725                 730                 735     


Arg Thr Val Ser Arg Val Glu Ser Phe Glu Asp Arg Ser Arg Pro Pro 
            740                 745                 750         


Phe Leu Pro Leu Pro Leu Thr Lys Pro Arg Ser Ile Ser Phe Pro Ser 
        755                 760                 765             


Ala Asp Thr Ser Asp Tyr Glu Asn Ile Pro Ala Met Asn Ser Asp Tyr 
    770                 775                 780                 


Glu Asn Ile Gln Ile Pro Pro Arg Arg Pro Ala Arg Ala Gly Ala Phe 
785                 790                 795                 800 


Thr Lys Leu Phe Glu Asp Gln Ser Arg Ala Leu Ser Thr Ala Asn Glu 
                805                 810                 815     


Asn Asp Gly Tyr Val Asp Met Ser Ser Phe Asn Ala Phe Glu Ser Lys 
            820                 825                 830         


Gln Gln Ser Ala Asp Gln Asp Ala Glu Ser Ala Tyr Thr Glu Pro Tyr 
        835                 840                 845             


Lys Val Cys Pro Ile Ser Ser Ala Ala Pro Lys Glu Asp Leu Thr Ser 
    850                 855                 860                 


Asp Glu Glu Gln Arg Ser Ser Glu Glu Glu Asp Ser Ala Ser Arg Asp 
865                 870                 875                 880 


Pro Ser Val Thr His Lys Val Glu Gly Gln Ser Arg Ala Leu Val Ile 
                885                 890                 895     


Ala Gln Glu Leu Leu Ser Ser Glu Lys Ala Tyr Val Glu Met Leu Gln 
            900                 905                 910         


His Leu Asn Leu Asp Phe His Gly Ala Val Met Arg Ala Leu Asp Asp 
        915                 920                 925             


Met Asp His Glu Gly Arg Asp Thr Leu Ala Arg Glu Glu Leu Arg Gln 
    930                 935                 940                 


Gly Leu Ser Glu Leu Pro Ala Ile His Asp Leu His Gln Gly Ile Leu 
945                 950                 955                 960 


Glu Glu Leu Glu Glu Arg Leu Ser Asn Trp Glu Ser Gln Gln Lys Val 
                965                 970                 975     


Ala Asp Val Phe Leu Ala Arg Glu Gln Gly Phe Asp His His Ala Thr 
            980                 985                 990         


His Ile Leu Gln Phe Asp Arg Tyr  Leu Gly Leu Leu Ser  Glu Asn Cys 
        995                 1000                 1005             


Leu His  Ser Pro Arg Leu Ala  Ala Ala Val Arg Glu  Phe Glu Gln 
    1010                 1015                 1020             


Ser Val  Gln Gly Gly Ser Gln  Thr Ala Lys His Arg  Leu Leu Arg 
    1025                 1030                 1035             


Val Val  Gln Arg Leu Phe Gln  Tyr Gln Val Leu Leu  Thr Asp Tyr 
    1040                 1045                 1050             


Leu Asn  Asn Leu Cys Pro Asp  Ser Ala Glu Tyr Asp  Asn Thr Gln 
    1055                 1060                 1065             


Gly Ala  Leu Ser Leu Ile Ser  Lys Val Thr Asp Arg  Ala Asn Asp 
    1070                 1075                 1080             


Ser Met  Glu Gln Gly Glu Asn  Leu Gln Lys Leu Val  His Ile Glu 
    1085                 1090                 1095             


His Ser  Val Arg Gly Gln Gly  Asp Leu Leu Gln Pro  Gly Arg Glu 
    1100                 1105                 1110             


Phe Leu  Lys Glu Gly Thr Leu  Met Lys Val Thr Gly  Lys Asn Arg 
    1115                 1120                 1125             


Arg Pro  Arg His Leu Phe Leu  Met Asn Asp Val Leu  Leu Tyr Thr 
    1130                 1135                 1140             


Tyr Pro  Gln Lys Asp Gly Lys  Tyr Arg Leu Lys Asn  Thr Leu Ala 
    1145                 1150                 1155             


Val Ala  Asn Met Lys Val Ser  Arg Pro Val Met Glu  Lys Val Pro 
    1160                 1165                 1170             


Tyr Ala  Leu Lys Ile Glu Thr  Ser Glu Ser Cys Leu  Met Leu Ser 
    1175                 1180                 1185             


Ala Ser  Ser Cys Ala Glu Arg  Asp Glu Trp Tyr Gly  Cys Leu Ser 
    1190                 1195                 1200             


Arg Ala  Leu Pro Glu Asp Tyr  Lys Ala Gln Ala Leu  Ala Ala Phe 
    1205                 1210                 1215             


His His  Ser Val Glu Ile Arg  Glu Arg Leu Gly Val  Ser Leu Gly 
    1220                 1225                 1230             


Glu Arg  Pro Pro Thr Leu Val  Pro Val Thr His Val  Met Met Cys 
    1235                 1240                 1245             


Met Asn  Cys Gly Cys Asp Phe  Ser Leu Thr Leu Arg  Arg His His 
    1250                 1255                 1260             


Cys His  Ala Cys Gly Lys Ile  Val Cys Arg Asn Cys  Ser Arg Asn 
    1265                 1270                 1275             


Lys Tyr  Pro Leu Lys Tyr Leu  Lys Asp Arg Met Ala  Lys Val Cys 
    1280                 1285                 1290             


Asp Gly  Cys Phe Gly Glu Leu  Lys Lys Arg Gly Arg  Ala Val Pro 
    1295                 1300                 1305             


Gly Leu  Met Arg Glu Arg Pro  Val Ser Met Ser Phe  Pro Leu Ser 
    1310                 1315                 1320             


Ser Pro  Arg Phe Ser Gly Ser  Ala Phe Ser Ser Val  Phe Gln Ser 
    1325                 1330                 1335             


Ile Asn  Pro Ser Thr Phe Lys  Lys Gln Lys Lys Val  Pro Ser Ala 
    1340                 1345                 1350             


Leu Thr  Glu Val Ala Ala Ser  Gly Glu Gly Ser Ala  Ile Ser Gly 
    1355                 1360                 1365             


Tyr Leu  Ser Arg Cys Lys Arg  Gly Lys Arg His Trp  Lys Lys Leu 
    1370                 1375                 1380             


Trp Phe  Val Ile Lys Gly Lys  Val Leu Tyr Thr Tyr  Met Ala Ser 
    1385                 1390                 1395             


Glu Asp  Lys Val Ala Leu Glu  Ser Met Pro Leu Leu  Gly Phe Thr 
    1400                 1405                 1410             


Ile Ala  Pro Glu Lys Glu Glu  Gly Ser Ser Glu Val  Gly Pro Ile 
    1415                 1420                 1425             


Phe His  Leu Tyr His Lys Lys  Thr Leu Phe Tyr Ser  Phe Lys Ala 
    1430                 1435                 1440             


Glu Asp  Thr Asn Ser Ala Gln  Arg Trp Ile Glu Ala  Met Glu Asp 
    1445                 1450                 1455             


Ala Ser  Val Leu 
    1460         


<210> 5089
<211> 255
<212> PRT
<213> Homo sapiens

<400> 5089
Met Ala Ser Ser Asp Leu Glu Gln Leu Cys Ser His Val Asn Glu Lys 
1               5                   10                  15      


Ile Gly Asn Ile Lys Lys Thr Leu Ser Leu Arg Asn Cys Gly Gln Glu 
            20                  25                  30          


Pro Thr Leu Lys Thr Val Leu Asn Lys Ile Gly Asp Glu Ile Ile Val 
        35                  40                  45              


Ile Asn Glu Leu Leu Asn Lys Leu Glu Leu Glu Ile Gln Tyr Gln Glu 
    50                  55                  60                  


Gln Thr Asn Asn Ser Leu Lys Glu Leu Cys Glu Ser Leu Glu Glu Asp 
65                  70                  75                  80  


Tyr Lys Asp Ile Glu His Leu Lys Glu Asn Val Pro Ser His Leu Pro 
                85                  90                  95      


Gln Val Thr Val Thr Gln Ser Cys Val Lys Gly Ser Asp Leu Asp Pro 
            100                 105                 110         


Glu Glu Pro Ile Lys Val Glu Glu Pro Glu Pro Val Lys Lys Pro Pro 
        115                 120                 125             


Lys Glu Gln Arg Ser Ile Lys Glu Met Pro Phe Ile Thr Cys Asp Glu 
    130                 135                 140                 


Phe Asn Gly Val Pro Ser Tyr Met Lys Ser Arg Leu Thr Tyr Asn Gln 
145                 150                 155                 160 


Ile Asn Asp Val Ile Lys Glu Ile Asn Lys Ala Val Ile Ser Lys Tyr 
                165                 170                 175     


Lys Ile Leu His Gln Pro Lys Lys Ser Met Asn Ser Val Thr Arg Asn 
            180                 185                 190         


Leu Tyr His Arg Phe Ile Asp Glu Glu Thr Lys Asp Thr Lys Gly Arg 
        195                 200                 205             


Tyr Phe Ile Val Glu Ala Asp Ile Lys Glu Phe Thr Thr Leu Lys Ala 
    210                 215                 220                 


Asp Lys Lys Phe His Val Leu Leu Asn Ile Leu Arg His Cys Arg Arg 
225                 230                 235                 240 


Leu Ser Glu Val Arg Gly Gly Gly Leu Thr Arg Tyr Val Ile Thr 
                245                 250                 255 


<210> 5090
<211> 208
<212> PRT
<213> Homo sapiens

<400> 5090
Met Ser Ala Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
1               5                   10                  15      


Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
            20                  25                  30          


Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
        35                  40                  45              


Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Val Arg Leu 
    50                  55                  60                  


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
65                  70                  75                  80  


Ser Tyr Ile Arg Asp Ser Thr Val Ala Val Val Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Leu Asn Ser Phe Gln Gln Thr Ser Lys Trp Ile Asp Asp Val Arg 
            100                 105                 110         


Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
        115                 120                 125             


Asp Leu Ala Asp Lys Arg Gln Ile Thr Ile Glu Glu Gly Glu Gln Arg 
    130                 135                 140                 


Ala Lys Glu Leu Ser Val Met Phe Ile Glu Thr Ser Ala Lys Thr Gly 
145                 150                 155                 160 


Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ser Ala Leu Pro Gly 
                165                 170                 175     


Met Glu Asn Val Gln Glu Lys Ser Lys Glu Gly Met Ile Asp Ile Lys 
            180                 185                 190         


Leu Asp Lys Pro Gln Glu Pro Pro Ala Ser Glu Gly Gly Cys Ser Cys 
        195                 200                 205             


<210> 5091
<211> 1055
<212> PRT
<213> Homo sapiens

<400> 5091
Met Thr Val Glu Gln Asn Val Leu Gln Gln Ser Ala Ala Gln Lys His 
1               5                   10                  15      


Gln Gln Thr Phe Leu Asn Gln Leu Arg Glu Ile Thr Gly Ile Asn Asp 
            20                  25                  30          


Thr Gln Ile Leu Gln Gln Ala Leu Lys Asp Ser Asn Gly Asn Leu Glu 
        35                  40                  45              


Leu Ala Val Ala Phe Leu Thr Ala Lys Asn Ala Lys Thr Pro Gln Gln 
    50                  55                  60                  


Glu Glu Thr Thr Tyr Tyr Gln Thr Ala Leu Pro Gly Asn Asp Arg Tyr 
65                  70                  75                  80  


Ile Ser Val Gly Ser Gln Ala Asp Thr Asn Val Ile Asp Leu Thr Gly 
                85                  90                  95      


Asp Asp Lys Asp Asp Leu Gln Arg Ala Ile Ala Leu Ser Leu Ala Glu 
            100                 105                 110         


Ser Asn Arg Ala Phe Arg Glu Thr Gly Ile Thr Asp Glu Glu Gln Ala 
        115                 120                 125             


Ile Ser Arg Val Leu Glu Ala Ser Ile Ala Glu Asn Lys Ala Cys Leu 
    130                 135                 140                 


Lys Arg Thr Pro Thr Glu Val Trp Arg Asp Ser Arg Asn Pro Tyr Asp 
145                 150                 155                 160 


Arg Lys Arg Gln Asp Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn 
                165                 170                 175     


Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu 
            180                 185                 190         


Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp 
        195                 200                 205             


Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu 
    210                 215                 220                 


Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val 
225                 230                 235                 240 


Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn 
                245                 250                 255     


Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp 
            260                 265                 270         


Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu 
        275                 280                 285             


Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu 
    290                 295                 300                 


Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe 
305                 310                 315                 320 


Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys 
                325                 330                 335     


Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu 
            340                 345                 350         


Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro 
        355                 360                 365             


Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly 
    370                 375                 380                 


Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr 
385                 390                 395                 400 


Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg 
                405                 410                 415     


Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg 
            420                 425                 430         


Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu 
        435                 440                 445             


Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val 
    450                 455                 460                 


Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly 
465                 470                 475                 480 


Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala 
                485                 490                 495     


Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile 
            500                 505                 510         


Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro 
        515                 520                 525             


Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile Thr Glu Glu Glu 
    530                 535                 540                 


Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu 
545                 550                 555                 560 


Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr 
                565                 570                 575     


Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg 
            580                 585                 590         


Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn Ala Gly His Tyr 
        595                 600                 605             


Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn 
    610                 615                 620                 


Asp Ile Ala Val Thr Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser 
625                 630                 635                 640 


Phe Gly Gly Tyr Arg Asn Ala Ser Ala Tyr Cys Leu Met Tyr Ile Asn 
                645                 650                 655     


Asp Lys Ala Gln Phe Leu Ile Gln Glu Glu Phe Asn Lys Glu Thr Gly 
            660                 665                 670         


Gln Pro Leu Val Gly Ile Glu Thr Leu Pro Pro Asp Leu Arg Asp Phe 
        675                 680                 685             


Val Glu Glu Asp Asn Gln Arg Phe Glu Lys Glu Leu Glu Glu Trp Asp 
    690                 695                 700                 


Ala Gln Leu Ala Gln Lys Ala Leu Gln Glu Lys Leu Leu Ala Ser Gln 
705                 710                 715                 720 


Lys Leu Arg Glu Ser Glu Thr Ser Val Thr Thr Ala Gln Ala Ala Gly 
                725                 730                 735     


Asp Pro Glu Tyr Leu Glu Gln Pro Ser Arg Ser Asp Phe Ser Lys His 
            740                 745                 750         


Leu Lys Glu Glu Thr Ile Gln Ile Ile Thr Lys Ala Ser His Glu His 
        755                 760                 765             


Glu Asp Lys Ser Pro Glu Thr Val Leu Gln Ser Ala Ile Lys Leu Glu 
    770                 775                 780                 


Tyr Ala Arg Leu Val Lys Leu Ala Gln Glu Asp Thr Pro Pro Glu Thr 
785                 790                 795                 800 


Asp Tyr Arg Leu His His Val Val Val Tyr Phe Ile Gln Asn Gln Ala 
                805                 810                 815     


Pro Lys Lys Ile Ile Glu Lys Thr Leu Leu Glu Gln Phe Gly Asp Arg 
            820                 825                 830         


Asn Leu Ser Phe Asp Glu Arg Cys His Asn Ile Met Lys Val Ala Gln 
        835                 840                 845             


Ala Lys Leu Glu Met Ile Lys Pro Glu Glu Val Asn Leu Glu Glu Tyr 
    850                 855                 860                 


Glu Glu Trp His Gln Asp Tyr Arg Lys Phe Arg Glu Thr Thr Met Tyr 
865                 870                 875                 880 


Leu Ile Ile Gly Leu Glu Asn Phe Gln Arg Glu Ser Tyr Ile Asp Ser 
                885                 890                 895     


Leu Leu Phe Leu Ile Cys Ala Tyr Gln Asn Asn Lys Glu Leu Leu Ser 
            900                 905                 910         


Lys Gly Leu Tyr Arg Gly His Asp Glu Glu Leu Ile Ser His Tyr Arg 
        915                 920                 925             


Arg Glu Cys Leu Leu Lys Leu Asn Glu Gln Ala Ala Glu Leu Phe Glu 
    930                 935                 940                 


Ser Gly Glu Asp Arg Glu Val Asn Asn Gly Leu Ile Ile Met Asn Glu 
945                 950                 955                 960 


Phe Ile Val Pro Phe Leu Pro Leu Leu Leu Val Asp Glu Met Glu Glu 
                965                 970                 975     


Lys Asp Ile Leu Ala Val Glu Asp Met Arg Asn Arg Trp Cys Ser Tyr 
            980                 985                 990         


Leu Gly Gln Glu Met Glu Pro His  Leu Gln Glu Lys Leu  Thr Asp Phe 
        995                 1000                 1005             


Leu Pro  Lys Leu Leu Asp Cys  Ser Met Glu Ile Lys  Ser Phe His 
    1010                 1015                 1020             


Glu Pro  Pro Lys Leu Pro Ser  Tyr Ser Thr His Glu  Leu Cys Glu 
    1025                 1030                 1035             


Arg Phe  Ala Arg Ile Met Leu  Ser Leu Ser Arg Thr  Pro Ala Asp 
    1040                 1045                 1050             


Gly Arg  
    1055 


<210> 5092
<211> 1087
<212> PRT
<213> Homo sapiens

<400> 5092
Met Thr Val Glu Gln Asn Val Leu Gln Gln Ser Ala Ala Gln Lys His 
1               5                   10                  15      


Gln Gln Thr Phe Leu Asn Gln Leu Arg Glu Ile Thr Gly Ile Asn Asp 
            20                  25                  30          


Thr Gln Ile Leu Gln Gln Ala Leu Lys Asp Ser Asn Gly Asn Leu Glu 
        35                  40                  45              


Leu Ala Val Ala Phe Leu Thr Ala Lys Asn Ala Lys Thr Pro Gln Gln 
    50                  55                  60                  


Glu Glu Thr Thr Tyr Tyr Gln Thr Ala Leu Pro Gly Asn Asp Arg Tyr 
65                  70                  75                  80  


Ile Ser Val Gly Ser Gln Ala Asp Thr Asn Val Ile Asp Leu Thr Gly 
                85                  90                  95      


Asp Asp Lys Asp Asp Leu Gln Arg Ala Ile Ala Leu Ser Leu Ala Glu 
            100                 105                 110         


Ser Asn Arg Ala Phe Arg Glu Thr Gly Ile Thr Asp Glu Glu Gln Ala 
        115                 120                 125             


Ile Ser Arg Val Leu Glu Ala Ser Ile Ala Glu Asn Lys Ala Cys Leu 
    130                 135                 140                 


Lys Arg Thr Pro Thr Glu Val Trp Arg Asp Ser Arg Asn Pro Tyr Asp 
145                 150                 155                 160 


Arg Lys Arg Gln Asp Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn 
                165                 170                 175     


Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu 
            180                 185                 190         


Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp 
        195                 200                 205             


Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu 
    210                 215                 220                 


Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val 
225                 230                 235                 240 


Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn 
                245                 250                 255     


Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp 
            260                 265                 270         


Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu 
        275                 280                 285             


Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu 
    290                 295                 300                 


Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe 
305                 310                 315                 320 


Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys 
                325                 330                 335     


Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu 
            340                 345                 350         


Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro 
        355                 360                 365             


Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly 
    370                 375                 380                 


Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr 
385                 390                 395                 400 


Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg 
                405                 410                 415     


Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg 
            420                 425                 430         


Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu 
        435                 440                 445             


Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val 
    450                 455                 460                 


Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly 
465                 470                 475                 480 


Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala 
                485                 490                 495     


Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile 
            500                 505                 510         


Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro 
        515                 520                 525             


Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile Thr Glu Glu Glu 
    530                 535                 540                 


Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu 
545                 550                 555                 560 


Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr 
                565                 570                 575     


Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg 
            580                 585                 590         


Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn Ala Gly His Tyr 
        595                 600                 605             


Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn 
    610                 615                 620                 


Asp Ile Ala Val Thr Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser 
625                 630                 635                 640 


Phe Gly Gly Tyr Arg Asn Ala Ser Ala Tyr Cys Leu Met Tyr Ile Asn 
                645                 650                 655     


Asp Lys Ala Gln Phe Leu Ile Gln Glu Glu Phe Asn Lys Glu Thr Gly 
            660                 665                 670         


Gln Pro Leu Val Gly Ile Glu Thr Leu Pro Pro Asp Leu Arg Asp Phe 
        675                 680                 685             


Val Glu Glu Asp Asn Gln Arg Phe Glu Lys Glu Leu Glu Glu Trp Asp 
    690                 695                 700                 


Ala Gln Leu Ala Gln Lys Ala Leu Gln Glu Lys Leu Leu Ala Ser Gln 
705                 710                 715                 720 


Lys Leu Arg Glu Ser Glu Thr Ser Val Thr Thr Ala Gln Ala Ala Gly 
                725                 730                 735     


Asp Pro Glu Tyr Leu Glu Gln Pro Ser Arg Ser Asp Phe Ser Lys His 
            740                 745                 750         


Leu Lys Glu Glu Thr Ile Gln Ile Ile Thr Lys Ala Ser His Glu His 
        755                 760                 765             


Glu Asp Lys Ser Pro Glu Thr Val Leu Gln Ser Ile Met Met Thr Pro 
    770                 775                 780                 


Asn Met Gln Gly Ile Ile Met Ala Ile Gly Lys Ser Arg Ser Val Tyr 
785                 790                 795                 800 


Asp Arg Cys Gly Pro Glu Ala Gly Phe Phe Lys Ala Ile Lys Leu Glu 
                805                 810                 815     


Tyr Ala Arg Leu Val Lys Leu Ala Gln Glu Asp Thr Pro Pro Glu Thr 
            820                 825                 830         


Asp Tyr Arg Leu His His Val Val Val Tyr Phe Ile Gln Asn Gln Ala 
        835                 840                 845             


Pro Lys Lys Ile Ile Glu Lys Thr Leu Leu Glu Gln Phe Gly Asp Arg 
    850                 855                 860                 


Asn Leu Ser Phe Asp Glu Arg Cys His Asn Ile Met Lys Val Ala Gln 
865                 870                 875                 880 


Ala Lys Leu Glu Met Ile Lys Pro Glu Glu Val Asn Leu Glu Glu Tyr 
                885                 890                 895     


Glu Glu Trp His Gln Asp Tyr Arg Lys Phe Arg Glu Thr Thr Met Tyr 
            900                 905                 910         


Leu Ile Ile Gly Leu Glu Asn Phe Gln Arg Glu Ser Tyr Ile Asp Ser 
        915                 920                 925             


Leu Leu Phe Leu Ile Cys Ala Tyr Gln Asn Asn Lys Glu Leu Leu Ser 
    930                 935                 940                 


Lys Gly Leu Tyr Arg Gly His Asp Glu Glu Leu Ile Ser His Tyr Arg 
945                 950                 955                 960 


Arg Glu Cys Leu Leu Lys Leu Asn Glu Gln Ala Ala Glu Leu Phe Glu 
                965                 970                 975     


Ser Gly Glu Asp Arg Glu Val Asn Asn Gly Leu Ile Ile Met Asn Glu 
            980                 985                 990         


Phe Ile Val Pro Phe Leu Pro Leu  Leu Leu Val Asp Glu  Met Glu Glu 
        995                 1000                 1005             


Lys Asp  Ile Leu Ala Val Glu  Asp Met Arg Asn Arg  Trp Cys Ser 
    1010                 1015                 1020             


Tyr Leu  Gly Gln Glu Met Glu  Pro His Leu Gln Glu  Lys Leu Thr 
    1025                 1030                 1035             


Asp Phe  Leu Pro Lys Leu Leu  Asp Cys Ser Met Glu  Ile Lys Ser 
    1040                 1045                 1050             


Phe His  Glu Pro Pro Lys Leu  Pro Ser Tyr Ser Thr  His Glu Leu 
    1055                 1060                 1065             


Cys Glu  Arg Phe Ala Arg Ile  Met Leu Ser Leu Ser  Arg Thr Pro 
    1070                 1075                 1080             


Ala Asp  Gly Arg 
    1085         


<210> 5093
<211> 852
<212> PRT
<213> Homo sapiens

<400> 5093
Met Ser Ser Val Ser Pro Ile Gln Ile Pro Ser Arg Leu Pro Leu Leu 
1               5                   10                  15      


Leu Thr His Glu Gly Val Leu Leu Pro Gly Ser Thr Met Arg Thr Ser 
            20                  25                  30          


Val Asp Ser Ala Arg Asn Leu Gln Leu Val Arg Ser Arg Leu Leu Lys 
        35                  40                  45              


Gly Thr Ser Leu Gln Ser Thr Ile Leu Gly Val Ile Pro Asn Thr Pro 
    50                  55                  60                  


Asp Pro Ala Ser Asp Ala Gln Asp Leu Pro Pro Leu His Arg Ile Gly 
65                  70                  75                  80  


Thr Ala Ala Leu Ala Val Gln Val Val Gly Ser Asn Trp Pro Lys Pro 
                85                  90                  95      


His Tyr Thr Leu Leu Ile Thr Gly Leu Cys Arg Phe Gln Ile Val Gln 
            100                 105                 110         


Val Leu Lys Glu Lys Pro Tyr Pro Ile Ala Glu Val Glu Gln Leu Asp 
        115                 120                 125             


Arg Leu Glu Glu Phe Pro Asn Thr Cys Lys Met Arg Glu Glu Leu Gly 
    130                 135                 140                 


Glu Leu Ser Glu Gln Phe Tyr Lys Tyr Ala Val Gln Leu Val Glu Met 
145                 150                 155                 160 


Leu Asp Met Ser Val Pro Ala Val Ala Lys Leu Arg Arg Leu Leu Asp 
                165                 170                 175     


Ser Leu Pro Arg Glu Ala Leu Pro Asp Ile Leu Thr Ser Ile Ile Arg 
            180                 185                 190         


Thr Ser Asn Lys Glu Lys Leu Gln Ile Leu Asp Ala Val Ser Leu Glu 
        195                 200                 205             


Glu Arg Phe Lys Met Thr Ile Pro Leu Leu Val Arg Gln Ile Glu Gly 
    210                 215                 220                 


Leu Lys Leu Leu Gln Lys Thr Arg Lys Pro Lys Gln Asp Asp Asp Lys 
225                 230                 235                 240 


Arg Val Ile Ala Ile Arg Pro Ile Arg Arg Ile Thr His Ile Ser Gly 
                245                 250                 255     


Thr Leu Glu Asp Glu Asp Glu Asp Glu Asp Asn Asp Asp Ile Val Met 
            260                 265                 270         


Leu Glu Lys Lys Ile Arg Thr Ser Ser Met Pro Glu Gln Ala His Lys 
        275                 280                 285             


Val Cys Val Lys Glu Ile Lys Arg Leu Lys Lys Met Pro Gln Ser Met 
    290                 295                 300                 


Pro Glu Tyr Ala Leu Thr Arg Asn Tyr Leu Glu Leu Met Val Glu Leu 
305                 310                 315                 320 


Pro Trp Asn Lys Ser Thr Thr Asp Arg Leu Asp Ile Arg Ala Ala Arg 
                325                 330                 335     


Ile Leu Leu Asp Asn Asp His Tyr Ala Met Glu Lys Leu Lys Lys Arg 
            340                 345                 350         


Val Leu Glu Tyr Leu Ala Val Arg Gln Leu Lys Asn Asn Leu Lys Gly 
        355                 360                 365             


Pro Ile Leu Cys Phe Val Gly Pro Pro Gly Val Gly Lys Thr Ser Val 
    370                 375                 380                 


Gly Arg Ser Val Ala Lys Thr Leu Gly Arg Glu Phe His Arg Ile Ala 
385                 390                 395                 400 


Leu Gly Gly Val Cys Asp Gln Ser Asp Ile Arg Gly His Arg Arg Thr 
                405                 410                 415     


Tyr Val Gly Ser Met Pro Gly Arg Ile Ile Asn Gly Leu Lys Thr Val 
            420                 425                 430         


Gly Val Asn Asn Pro Val Phe Leu Leu Asp Glu Val Asp Lys Leu Gly 
        435                 440                 445             


Lys Ser Leu Gln Gly Asp Pro Ala Ala Ala Leu Leu Glu Val Leu Asp 
    450                 455                 460                 


Pro Glu Gln Asn His Asn Phe Thr Asp His Tyr Leu Asn Val Ala Phe 
465                 470                 475                 480 


Asp Leu Ser Gln Val Leu Phe Ile Ala Thr Ala Asn Thr Thr Ala Thr 
                485                 490                 495     


Ile Pro Ala Ala Leu Leu Asp Arg Met Glu Ile Ile Gln Val Pro Gly 
            500                 505                 510         


Tyr Thr Gln Glu Glu Lys Ile Glu Ile Ala His Arg His Leu Ile Pro 
        515                 520                 525             


Lys Gln Leu Glu Gln His Gly Leu Thr Pro Gln Gln Ile Gln Ile Pro 
    530                 535                 540                 


Gln Val Thr Thr Leu Asp Ile Ile Thr Arg Tyr Thr Arg Glu Ala Gly 
545                 550                 555                 560 


Val Arg Ser Leu Asp Arg Lys Leu Gly Ala Ile Cys Arg Ala Val Ala 
                565                 570                 575     


Val Lys Val Ala Glu Gly Gln His Lys Glu Ala Lys Leu Asp Arg Ser 
            580                 585                 590         


Asp Val Thr Glu Arg Glu Gly Cys Arg Glu His Ile Leu Glu Asp Glu 
        595                 600                 605             


Lys Pro Glu Ser Ile Ser Asp Thr Thr Asp Leu Ala Leu Pro Pro Glu 
    610                 615                 620                 


Met Pro Ile Leu Ile Asp Phe His Ala Leu Lys Asp Ile Leu Gly Pro 
625                 630                 635                 640 


Pro Met Tyr Glu Met Glu Val Ser Gln Arg Leu Ser Gln Pro Gly Val 
                645                 650                 655     


Ala Ile Gly Leu Ala Trp Thr Pro Leu Gly Gly Glu Ile Met Phe Val 
            660                 665                 670         


Glu Ala Ser Arg Met Asp Gly Glu Gly Gln Leu Thr Leu Thr Gly Gln 
        675                 680                 685             


Leu Gly Asp Val Met Lys Glu Ser Ala His Leu Ala Ile Ser Trp Leu 
    690                 695                 700                 


Arg Ser Asn Ala Lys Lys Tyr Gln Leu Thr Asn Ala Phe Gly Ser Phe 
705                 710                 715                 720 


Asp Leu Leu Asp Asn Thr Asp Ile His Leu His Phe Pro Ala Gly Ala 
                725                 730                 735     


Val Thr Lys Asp Gly Pro Ser Ala Gly Val Thr Ile Val Thr Cys Leu 
            740                 745                 750         


Ala Ser Leu Phe Ser Gly Arg Leu Val Arg Ser Asp Val Ala Met Thr 
        755                 760                 765             


Gly Glu Ile Thr Leu Arg Gly Leu Val Leu Pro Val Gly Gly Ile Lys 
    770                 775                 780                 


Asp Lys Val Leu Ala Ala His Arg Ala Gly Leu Lys Gln Val Ile Ile 
785                 790                 795                 800 


Pro Arg Arg Asn Glu Lys Asp Leu Glu Gly Ile Pro Gly Asn Val Arg 
                805                 810                 815     


Gln Asp Leu Ser Phe Val Thr Ala Ser Cys Leu Asp Glu Val Leu Asn 
            820                 825                 830         


Ala Ala Phe Asp Gly Gly Phe Thr Val Lys Thr Arg Pro Gly Leu Leu 
        835                 840                 845             


Asn Ser Lys Leu 
    850         


<210> 5094
<211> 129
<212> PRT
<213> Homo sapiens

<400> 5094
Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 
        35                  40                  45              


Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 
    50                  55                  60                  


Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro 
65                  70                  75                  80  


Ala Tyr Gln Asn Leu Arg Gln Lys Val Asp Asn Phe Val Ser Thr His 
                85                  90                  95      


Leu Asp Lys Gln Glu Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg 
            100                 105                 110         


Asn Gly Leu Arg Gln Ser Val Val Gln Ile Arg Gln Thr Pro Phe Glu 
        115                 120                 125             


Ser 
    


<210> 5095
<211> 474
<212> PRT
<213> Homo sapiens

<400> 5095
Met Asp Glu Ala Gly Ser Ser Ala Ser Gly Gly Gly Phe Arg Pro Gly 
1               5                   10                  15      


Val Asp Ser Leu Asp Glu Pro Pro Asn Ser Arg Ile Phe Leu Val Ile 
            20                  25                  30          


Ser Lys Tyr Thr Pro Glu Ser Val Leu Arg Glu Arg Phe Ser Pro Phe 
        35                  40                  45              


Gly Asp Ile Gln Asp Ile Trp Val Val Arg Asp Lys His Thr Lys Glu 
    50                  55                  60                  


Ser Lys Gly Ile Ala Phe Val Lys Phe Ala Arg Ser Ser Gln Ala Cys 
65                  70                  75                  80  


Arg Ala Met Glu Glu Met His Gly Gln Cys Leu Gly Pro Asn Asp Thr 
                85                  90                  95      


Lys Pro Ile Lys Val Phe Ile Ala Gln Ser Arg Ser Ser Gly Ser His 
            100                 105                 110         


Arg Asp Val Glu Asp Glu Glu Leu Thr Arg Ile Phe Val Met Ile Pro 
        115                 120                 125             


Lys Ser Tyr Thr Glu Glu Asp Leu Arg Glu Lys Phe Lys Val Tyr Gly 
    130                 135                 140                 


Asp Ile Glu Tyr Cys Ser Ile Ile Lys Asn Lys Val Thr Gly Glu Ser 
145                 150                 155                 160 


Lys Gly Leu Gly Tyr Val Arg Tyr Leu Lys Pro Ser Gln Ala Ala Gln 
                165                 170                 175     


Ala Ile Glu Asn Cys Asp Arg Ser Phe Arg Ala Ile Leu Ala Glu Pro 
            180                 185                 190         


Lys Asn Lys Ala Ser Glu Ser Ser Glu Gln Asp Tyr Tyr Ser Asn Met 
        195                 200                 205             


Arg Gln Glu Ala Leu Gly His Glu Pro Arg Val Asn Met Phe Pro Phe 
    210                 215                 220                 


Glu Gln Gln Ser Glu Phe Ser Ser Phe Asp Lys Asn Asp Ser Arg Gly 
225                 230                 235                 240 


Gln Glu Ala Ile Ser Lys Arg Leu Ser Val Val Ser Arg Val Pro Phe 
                245                 250                 255     


Thr Glu Glu Gln Leu Phe Ser Ile Phe Asp Ile Val Pro Gly Leu Glu 
            260                 265                 270         


Tyr Cys Glu Val Gln Arg Asp Pro Tyr Ser Asn Tyr Gly His Gly Val 
        275                 280                 285             


Val Gln Tyr Phe Asn Val Ala Ser Ala Ile Tyr Ala Lys Tyr Lys Leu 
    290                 295                 300                 


His Gly Phe Gln Tyr Pro Pro Gly Asn Arg Ile Gly Val Ser Phe Ile 
305                 310                 315                 320 


Asp Asp Gly Ser Asn Ala Thr Asp Leu Leu Arg Lys Met Ala Thr Gln 
                325                 330                 335     


Met Val Ala Ala Gln Leu Ala Ser Met Val Trp Asn Asn Pro Ser Gln 
            340                 345                 350         


Gln Gln Phe Met Gln Phe Gly Gly Ser Ser Gly Ser Gln Leu Pro Gln 
        355                 360                 365             


Ile Gln Thr Asp Val Val Leu Pro Ser Cys Lys Lys Lys Ala Pro Ala 
    370                 375                 380                 


Glu Thr Pro Val Lys Glu Arg Leu Phe Ile Val Phe Asn Pro His Pro 
385                 390                 395                 400 


Leu Pro Leu Asp Val Leu Glu Asp Ile Phe Cys Arg Phe Gly Asn Leu 
                405                 410                 415     


Ile Glu Val Tyr Leu Val Ser Gly Lys Asn Val Gly Tyr Ala Lys Tyr 
            420                 425                 430         


Ala Asp Arg Ile Ser Ala Asn Asp Ala Ile Ala Thr Leu His Gly Lys 
        435                 440                 445             


Ile Leu Asn Gly Val Arg Leu Lys Val Met Leu Ala Asp Ser Pro Arg 
    450                 455                 460                 


Glu Glu Ser Asn Lys Arg Gln Arg Thr Tyr 
465                 470                 


<210> 5096
<211> 645
<212> PRT
<213> Homo sapiens

<400> 5096
Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 
            20                  25                  30          


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
    50                  55                  60                  


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
65                  70                  75                  80  


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
                85                  90                  95      


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
            100                 105                 110         


Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 
        115                 120                 125             


Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 
    130                 135                 140                 


Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 
145                 150                 155                 160 


Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 
                165                 170                 175     


Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 
            180                 185                 190         


Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
        195                 200                 205             


Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 
    210                 215                 220                 


Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 
225                 230                 235                 240 


Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 
                245                 250                 255     


Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 
            260                 265                 270         


Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 
        275                 280                 285             


Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 
    290                 295                 300                 


Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 
                325                 330                 335     


His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 
            340                 345                 350         


Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 
        355                 360                 365             


Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 
    370                 375                 380                 


Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 
385                 390                 395                 400 


Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 
                405                 410                 415     


Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 
            420                 425                 430         


Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 
        435                 440                 445             


Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 
    450                 455                 460                 


Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 
465                 470                 475                 480 


Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 
                485                 490                 495     


Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 
            500                 505                 510         


Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 
        515                 520                 525             


Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 
    530                 535                 540                 


Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
545                 550                 555                 560 


Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys 
                565                 570                 575     


Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 
            580                 585                 590         


Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 
        595                 600                 605             


Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 
    610                 615                 620                 


Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 
625                 630                 635                 640 


Thr Lys Glu Glu Leu 
                645 


<210> 5097
<211> 445
<212> PRT
<213> Homo sapiens

<400> 5097
Met Tyr Pro Asn Pro Leu Ile Tyr Cys Thr Cys Trp Asp Pro Trp Asn 
1               5                   10                  15      


Leu Gly Pro Arg Lys Leu Ile Lys Thr Pro Gln Leu Pro Arg Lys Asn 
            20                  25                  30          


Ser Thr Gly Ser Ser Lys Leu Thr Pro Leu Val Pro Ala Pro Lys Asn 
        35                  40                  45              


His Asn Tyr Leu Gln Pro Thr Lys Pro Val Val Ser Pro Lys Met Lys 
    50                  55                  60                  


Ile His Ser Ala Arg Gln Glu Glu Thr Asn Lys Ser Phe Tyr Glu Val 
65                  70                  75                  80  


Ile Asn Val Ser Pro Gly Tyr Gln Leu Val Arg Asn Arg Glu Gln Ile 
                85                  90                  95      


Ser Val Thr Leu Gly Asp Glu Met Phe Asp Arg Lys Lys Arg Trp Glu 
            100                 105                 110         


Ser Glu Ile Pro Asp Lys Gly Arg Phe Ser Arg Thr Asn Ile Ile Ser 
        115                 120                 125             


Asp Leu Glu Glu Gln Ile Ser Glu Leu Thr Ala Ile Ile Glu Gln Met 
    130                 135                 140                 


Asn Arg Asp His Gln Ser Ala Gln Lys Leu Leu Ser Ser Glu Met Asp 
145                 150                 155                 160 


Leu Arg Cys Ala Glu Met Lys Gln Asn Phe Glu Asn Lys Asn Arg Glu 
                165                 170                 175     


Leu Lys Glu Ala His Glu Ala Glu Leu Ser Glu Leu Glu Asn Asn Tyr 
            180                 185                 190         


Lys Ala Ala Leu Lys Ala Glu Lys Leu Ala Ala Gln Glu Lys Leu Glu 
        195                 200                 205             


Glu Met Gly Lys Glu Tyr Lys Tyr Leu Lys Asn Met Phe Arg Thr Tyr 
    210                 215                 220                 


Gln Asp Ser Ile Tyr Asp Glu Met Glu Glu Lys Trp Ser Lys Gln Lys 
225                 230                 235                 240 


Ala Lys Trp Lys Lys Asp Glu Lys Phe Glu Arg Glu Asn Ile Leu Leu 
                245                 250                 255     


Gln Gln Lys Lys Lys Met Thr Lys Lys Phe Glu Met Glu Ser Gly Glu 
            260                 265                 270         


Glu Asp Lys Lys Ile Asn Glu Ser Cys Ser Ala Val Phe Glu Asn Phe 
        275                 280                 285             


Ile Gln Glu Lys Glu Glu Leu Leu Lys Gln His Gln Ser Asp Thr Leu 
    290                 295                 300                 


Gln Leu Glu Glu Leu Arg Lys Thr Lys Glu Val Pro Trp Arg Arg Asp 
305                 310                 315                 320 


Gln Ile Asn Arg His Trp His Asp Val Leu Gln Gln Leu Leu Leu Met 
                325                 330                 335     


Gln Val Met Gln Glu Glu Leu His Ala Gln Ala Leu Ile Leu Glu Ser 
            340                 345                 350         


Leu Asn Thr Asn Leu Tyr Tyr Thr Gln Leu Glu Leu Gln Lys Glu Lys 
        355                 360                 365             


Ala Ile Val Gly Asn Leu Glu Lys Met Leu Gln Thr Lys Phe Ala Glu 
    370                 375                 380                 


Thr Glu Glu Lys Tyr Lys His Thr Ile Gln Ile Leu Thr Glu Glu Asn 
385                 390                 395                 400 


Ile His Leu Lys Gln Lys Ile Ile Ser Lys Asn Glu Glu Ile Cys Glu 
                405                 410                 415     


Gly Cys Ser Gly Arg Leu Ala Ser Ile Thr Val Ser Lys Asp Asp Ser 
            420                 425                 430         


Asp Thr Val Gln Asp Gly Ser Lys Lys Gly Gln Glu Ser 
        435                 440                 445 


<210> 5098
<211> 623
<212> PRT
<213> Homo sapiens

<400> 5098
Met Glu Pro Pro Gln Glu Thr Asn Arg Pro Phe Ser Thr Leu Asp Asn 
1               5                   10                  15      


Arg Ser Gly Gln Val Gln Val Leu Ser Ala Thr Pro Leu Leu Gln Arg 
            20                  25                  30          


Asn Pro Tyr Ser Ser Pro Asp Ile Met His Ile Lys Gly Ser Glu Ala 
        35                  40                  45              


Ser Ser Val Pro Tyr Ala Leu Asn Gln Gly Thr Thr Ala Leu Pro Lys 
    50                  55                  60                  


Asn Lys Asn Gln Glu Gly Thr Gly His Arg Leu Leu Asn Met Leu Arg 
65                  70                  75                  80  


Lys Thr Leu Lys Glu Ser Asp Ser Glu Glu Leu Glu Ile Thr Gln Glu 
                85                  90                  95      


Thr Pro Asn Leu Val Pro Phe Gly Asp Val Val Gly Cys Leu Gly Ile 
            100                 105                 110         


His Ile Lys Asn Cys Arg His Phe Met Pro Lys Ile Ser Leu Gln His 
        115                 120                 125             


Tyr Ala Asn Leu Phe Ile Arg Ile Ser Ile Asn Lys Ala Val Lys Cys 
    130                 135                 140                 


Thr Lys Met Cys Ser Leu Leu Ser Lys Asn Asp Glu Lys Asn Thr Val 
145                 150                 155                 160 


Ile Lys Phe Asp Glu Val Lys Tyr Phe Ser Val Gln Val Pro Arg Arg 
                165                 170                 175     


Tyr Asp Asp Lys Arg Asn Asn Ile Leu Leu Glu Leu Ile Gln Tyr Asp 
            180                 185                 190         


Asn Arg Glu Lys Arg Ala Phe Leu Leu Gly Ser Val Gln Ile His Leu 
        195                 200                 205             


Tyr Glu Val Ile Gln Lys Gly Cys Phe Ile Glu Glu Val Gln Val Leu 
    210                 215                 220                 


His Gly Asn Ile Phe Val Cys Arg Leu Glu Val Glu Phe Met Phe Ser 
225                 230                 235                 240 


Tyr Gly Asn Phe Gly Tyr Gly Phe Ser His Gln Leu Lys Pro Leu Gln 
                245                 250                 255     


Lys Ile Thr Glu Pro Ser Met Phe Met Asn Leu Ala Pro Pro Pro Glu 
            260                 265                 270         


Arg Thr Asp Pro Val Thr Lys Val Ile Thr Pro Gln Thr Val Glu Tyr 
        275                 280                 285             


Pro Ala Phe Leu Ser Pro Asp Leu Asn Val Thr Val Gly Thr Pro Ala 
    290                 295                 300                 


Val Gln Ser Ser Asn Gln Pro Ser Val Val Arg Leu Glu Lys Leu Gln 
305                 310                 315                 320 


Gln Gln Pro Arg Glu Arg Leu Glu Lys Met Lys Lys Glu Tyr Arg Asn 
                325                 330                 335     


Leu Asn Thr Trp Ile Asp Lys Ala Asn Tyr Leu Glu Ser Ile Leu Met 
            340                 345                 350         


Pro Lys Leu Glu His Lys Asp Ser Glu Glu Thr Asn Ile Asp Glu Ala 
        355                 360                 365             


Ser Glu Asn Thr Lys Ser Asn His Pro Glu Glu Glu Leu Glu Asn Ile 
    370                 375                 380                 


Val Gly Val Asp Ile Pro Leu Val Asn Glu Glu Ala Glu Thr Thr Ala 
385                 390                 395                 400 


Asn Glu Leu Leu Asp Asn Asp Ser Glu Lys Gly Leu Thr Ile Pro Thr 
                405                 410                 415     


Leu Asn Gln Ser Asp Gln Asp Asn Ser Thr Ala Asp Ala Ser Lys Asn 
            420                 425                 430         


Asp Glu Ser Thr Pro Ser Pro Thr Glu Val His Ser Leu Cys Thr Ile 
        435                 440                 445             


Ser Asn Gln Glu Thr Ile Lys Ala Gly Arg Ile Pro Pro Leu Gly Glu 
    450                 455                 460                 


Arg Gln Ser Glu Ser Met Pro Asp Arg Lys Met Lys Asn Val Phe Phe 
465                 470                 475                 480 


Pro Leu Glu Val Lys Leu Lys Asp Asn Tyr Pro Ser Ile Leu Lys Ala 
                485                 490                 495     


Asp Ser Ser Leu Ser Glu Val Ala Phe Ser Pro Lys Glu Tyr Asn Ser 
            500                 505                 510         


Pro Ser Phe Arg Pro Glu Tyr Ile Glu Phe Lys Pro Lys Phe Gln Asp 
        515                 520                 525             


Cys Ser Asp Lys Phe Glu Asp Leu His Asp Met Thr Ser Phe Thr His 
    530                 535                 540                 


Leu Lys Lys Val Lys Ser Arg Ser Arg Leu Leu Gly Lys Ser Ser Asp 
545                 550                 555                 560 


Asp Ile His Asn His Ala Arg His Ser Ala Arg Pro Tyr Thr Ala Pro 
                565                 570                 575     


Glu Val Asn Lys Gln Arg Glu Ser Tyr Ser Gly Lys Phe Thr Ser Arg 
            580                 585                 590         


Arg Met Val Ser Ser Gly Leu Val His Ile Asn Asp Lys Thr Ser Asp 
        595                 600                 605             


Tyr Glu Met His Lys Met Arg Pro Lys Lys Ile Lys Arg Gly Tyr 
    610                 615                 620             


<210> 5099
<211> 1197
<212> PRT
<213> Homo sapiens

<400> 5099
Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln 
1               5                   10                  15      


Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly 
            20                  25                  30          


Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu 
        35                  40                  45              


Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser 
65                  70                  75                  80  


Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu 
                85                  90                  95      


Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg 
            100                 105                 110         


Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln 
        115                 120                 125             


Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu 
    130                 135                 140                 


Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu 
145                 150                 155                 160 


Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr 
                165                 170                 175     


Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu 
            180                 185                 190         


Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln 
        195                 200                 205             


Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met 
    210                 215                 220                 


Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met 
                245                 250                 255     


Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys 
            260                 265                 270         


Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys 
        275                 280                 285             


Asp Lys Glu Thr Gly Gly Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala 
    290                 295                 300                 


Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys 
                325                 330                 335     


Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Val 
            340                 345                 350         


Lys Lys Ile Thr Asp Gly Leu His Ala Leu Gln Glu Ala Ser Asn Lys 
        355                 360                 365             


Asp Ala Glu Ala Leu Ala Ala Ala Gln Gln His Phe Asn Ala Val Ser 
    370                 375                 380                 


Ala Gly Leu Ser Ser Asn Glu Asp Gly Ala Glu Ala Thr Leu Ala Gly 
385                 390                 395                 400 


Gln Met Met Ala Cys Lys Asn Asp Ile Ser Lys Ala Gln Thr Glu Ala 
                405                 410                 415     


Lys Gln Ala Gln Met Lys Leu Lys His Ala Gln Gln Glu Leu Lys Asn 
            420                 425                 430         


Lys Gln Ala Glu Val Lys Lys Met Asp Ser Gly Tyr Arg Lys Asp Gln 
        435                 440                 445             


Glu Ala Leu Glu Ala Val Lys Arg Leu Lys Glu Lys Leu Glu Ala Glu 
    450                 455                 460                 


Met Lys Lys Leu Asn Tyr Glu Glu Asn Lys Glu Glu Ser Leu Leu Glu 
465                 470                 475                 480 


Lys Arg Arg Gln Leu Ser Arg Asp Ile Gly Arg Leu Lys Glu Thr Tyr 
                485                 490                 495     


Glu Ala Leu Leu Ala Arg Phe Pro Asn Leu Arg Phe Ala Tyr Lys Asp 
            500                 505                 510         


Pro Glu Lys Asn Trp Asn Arg Asn Cys Val Lys Gly Leu Val Ala Ser 
        515                 520                 525             


Leu Ile Ser Val Lys Asp Thr Ser Ala Thr Thr Ala Leu Glu Leu Val 
    530                 535                 540                 


Ala Gly Glu Arg Leu Tyr Asn Val Val Val Asp Thr Glu Val Thr Gly 
545                 550                 555                 560 


Lys Lys Leu Leu Glu Arg Gly Glu Leu Lys Arg Arg Tyr Thr Ile Ile 
                565                 570                 575     


Pro Leu Asn Lys Ile Ser Ala Arg Cys Ile Ala Pro Glu Thr Leu Arg 
            580                 585                 590         


Val Ala Gln Asn Leu Val Gly Pro Asp Asn Val His Val Ala Leu Ser 
        595                 600                 605             


Leu Val Glu Tyr Lys Pro Glu Leu Gln Lys Ala Met Glu Phe Val Phe 
    610                 615                 620                 


Gly Thr Thr Phe Val Cys Asp Asn Met Asp Asn Ala Lys Lys Val Ala 
625                 630                 635                 640 


Phe Asp Lys Arg Ile Met Thr Arg Thr Val Thr Leu Gly Gly Asp Val 
                645                 650                 655     


Phe Asp Pro His Gly Thr Leu Ser Gly Gly Ala Arg Ser Gln Ala Ala 
            660                 665                 670         


Ser Ile Leu Thr Lys Phe Gln Glu Leu Lys Asp Val Gln Asp Glu Leu 
        675                 680                 685             


Arg Ile Lys Glu Asn Glu Leu Arg Ala Leu Glu Glu Glu Leu Ala Gly 
    690                 695                 700                 


Leu Lys Asn Thr Ala Glu Lys Tyr Arg Gln Leu Lys Gln Gln Trp Glu 
705                 710                 715                 720 


Met Lys Thr Glu Glu Ala Asp Leu Leu Gln Thr Lys Leu Gln Gln Ser 
                725                 730                 735     


Ser Tyr His Lys Gln Gln Glu Glu Leu Asp Ala Leu Lys Lys Thr Ile 
            740                 745                 750         


Glu Glu Ser Glu Glu Thr Leu Lys Asn Thr Lys Glu Ile Gln Arg Lys 
        755                 760                 765             


Ala Glu Glu Lys Tyr Glu Val Leu Glu Asn Lys Met Lys Asn Ala Glu 
    770                 775                 780                 


Ala Glu Arg Glu Arg Glu Leu Lys Asp Ala Gln Lys Lys Leu Asp Cys 
785                 790                 795                 800 


Ala Lys Thr Lys Ala Asp Ala Ser Ser Lys Lys Met Lys Glu Lys Gln 
                805                 810                 815     


Gln Glu Val Glu Ala Ile Thr Leu Glu Leu Glu Glu Leu Lys Arg Glu 
            820                 825                 830         


His Thr Ser Tyr Lys Gln Gln Leu Glu Ala Val Asn Glu Ala Ile Lys 
        835                 840                 845             


Ser Tyr Glu Ser Gln Ile Glu Val Met Ala Ala Glu Val Ala Lys Asn 
    850                 855                 860                 


Lys Glu Ser Val Asn Lys Ala Gln Glu Glu Val Thr Lys Gln Lys Glu 
865                 870                 875                 880 


Val Ile Thr Ala Gln Asp Thr Val Ile Lys Ala Lys Tyr Ala Glu Val 
                885                 890                 895     


Ala Lys His Lys Glu Gln Asn Asn Asp Ser Gln Leu Lys Ile Lys Glu 
            900                 905                 910         


Leu Asp His Asn Ile Ser Lys His Lys Arg Glu Ala Glu Asp Gly Ala 
        915                 920                 925             


Ala Lys Val Ser Lys Met Leu Lys Asp Tyr Asp Trp Ile Asn Ala Glu 
    930                 935                 940                 


Arg His Leu Phe Gly Gln Pro Asn Ser Ala Tyr Asp Phe Lys Thr Asn 
945                 950                 955                 960 


Asn Pro Lys Glu Ala Gly Gln Arg Leu Gln Lys Leu Gln Glu Met Lys 
                965                 970                 975     


Glu Lys Leu Gly Arg Asn Val Asn Met Arg Ala Met Asn Val Leu Thr 
            980                 985                 990         


Glu Ala Glu Glu Arg Tyr Asn Asp  Leu Met Lys Lys Lys  Arg Ile Val 
        995                 1000                 1005             


Glu Asn  Asp Lys Ser Lys Ile  Leu Thr Thr Ile Glu  Asp Leu Asp 
    1010                 1015                 1020             


Gln Lys  Lys Asn Gln Ala Leu  Asn Ile Ala Trp Gln  Lys Val Asn 
    1025                 1030                 1035             


Lys Asp  Phe Gly Ser Ile Phe  Ser Thr Leu Leu Pro  Gly Ala Asn 
    1040                 1045                 1050             


Ala Met  Leu Ala Pro Pro Glu  Gly Gln Thr Val Leu  Asp Gly Leu 
    1055                 1060                 1065             


Glu Phe  Lys Val Ala Leu Gly  Asn Thr Trp Lys Glu  Asn Leu Thr 
    1070                 1075                 1080             


Glu Leu  Ser Gly Gly Gln Arg  Ser Leu Val Ala Leu  Ser Leu Ile 
    1085                 1090                 1095             


Leu Ser  Met Leu Leu Phe Lys  Pro Ala Pro Ile Tyr  Ile Leu Asp 
    1100                 1105                 1110             


Glu Val  Asp Ala Ala Leu Asp  Leu Ser His Thr Gln  Asn Ile Gly 
    1115                 1120                 1125             


Gln Met  Leu Arg Thr His Phe  Thr His Ser Gln Phe  Ile Val Val 
    1130                 1135                 1140             


Ser Leu  Lys Glu Gly Met Phe  Asn Asn Ala Asn Val  Leu Phe Lys 
    1145                 1150                 1155             


Thr Lys  Phe Val Asp Gly Val  Ser Thr Val Ala Arg  Phe Thr Gln 
    1160                 1165                 1170             


Cys Gln  Asn Gly Lys Ile Ser  Lys Glu Ala Lys Ser  Lys Ala Lys 
    1175                 1180                 1185             


Pro Pro  Lys Gly Ala His Val  Glu Val 
    1190                 1195         


<210> 5100
<211> 359
<212> PRT
<213> Homo sapiens

<400> 5100
Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala 
        195                 200                 205             


Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu 
    210                 215                 220                 


Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr 
225                 230                 235                 240 


Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg 
                245                 250                 255     


Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp 
            260                 265                 270         


Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr 
        275                 280                 285             


Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala 
    290                 295                 300                 


Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Gln Ile Leu Ser Val Val Pro Val Tyr Asn Asn Phe Thr Ile 
                325                 330                 335     


Tyr Thr Thr Val Met Ser Ala Gly Ser Pro Asp Lys Tyr Met Thr Arg 
            340                 345                 350         


Ile Arg Asn Pro Ser Arg Lys 
        355                 


<210> 5101
<211> 548
<212> PRT
<213> Homo sapiens

<400> 5101
Met Ala Leu His Val Pro Lys Ala Pro Gly Phe Ala Gln Met Leu Lys 
1               5                   10                  15      


Glu Gly Ala Lys His Phe Ser Gly Leu Glu Glu Ala Val Tyr Arg Asn 
            20                  25                  30          


Ile Gln Ala Cys Lys Glu Leu Ala Gln Thr Thr Arg Thr Ala Tyr Gly 
        35                  40                  45              


Pro Asn Gly Met Asn Lys Met Val Ile Asn His Leu Glu Lys Leu Phe 
    50                  55                  60                  


Val Thr Asn Asp Ala Ala Thr Ile Leu Arg Glu Leu Glu Val Gln His 
65                  70                  75                  80  


Pro Ala Ala Lys Met Ile Val Met Ala Ser His Met Gln Glu Gln Glu 
                85                  90                  95      


Val Gly Asp Gly Thr Asn Phe Val Leu Val Phe Ala Gly Ala Leu Leu 
            100                 105                 110         


Glu Leu Ala Glu Glu Leu Leu Arg Ile Gly Leu Ser Val Ser Glu Val 
        115                 120                 125             


Ile Glu Gly Tyr Glu Ile Ala Cys Arg Lys Ala His Glu Ile Leu Pro 
    130                 135                 140                 


Asn Leu Val Cys Cys Ser Ala Lys Asn Leu Arg Asp Ile Asp Glu Val 
145                 150                 155                 160 


Ser Ser Leu Leu Arg Thr Ser Ile Met Ser Lys Gln Tyr Gly Asn Glu 
                165                 170                 175     


Val Phe Leu Ala Lys Leu Ile Ala Gln Ala Cys Val Ser Ile Phe Pro 
            180                 185                 190         


Asp Ser Gly His Phe Asn Val Asp Asn Ile Arg Val Cys Lys Ile Leu 
        195                 200                 205             


Gly Ser Gly Ile Ser Ser Ser Ser Val Leu His Gly Met Val Phe Lys 
    210                 215                 220                 


Lys Glu Thr Glu Gly Asp Val Thr Ser Val Lys Asp Ala Lys Ile Ala 
225                 230                 235                 240 


Val Tyr Ser Cys Pro Phe Asp Gly Met Ile Thr Glu Thr Lys Gly Thr 
                245                 250                 255     


Val Leu Ile Lys Thr Ala Glu Glu Leu Met Asn Phe Ser Lys Gly Glu 
            260                 265                 270         


Glu Asn Leu Met Asp Ala Gln Val Lys Ala Ile Ala Asp Thr Gly Ala 
        275                 280                 285             


Asn Val Val Val Thr Gly Gly Lys Val Ala Asp Met Ala Leu His Tyr 
    290                 295                 300                 


Ala Asn Lys Tyr Asn Ile Met Leu Val Arg Leu Asn Ser Lys Trp Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Cys Lys Thr Val Gly Ala Thr Ala Leu Pro Arg Leu 
                325                 330                 335     


Thr Pro Pro Val Leu Glu Glu Met Gly His Cys Asp Ser Val Tyr Leu 
            340                 345                 350         


Ser Glu Val Gly Asp Thr Gln Val Val Val Phe Lys His Glu Lys Glu 
        355                 360                 365             


Asp Gly Ala Ile Ser Thr Ile Val Leu Arg Gly Ser Thr Asp Asn Leu 
    370                 375                 380                 


Met Asp Asp Ile Glu Arg Ala Val Asp Asp Gly Val Asn Thr Phe Lys 
385                 390                 395                 400 


Val Leu Thr Arg Asp Lys Arg Leu Val Pro Gly Gly Gly Ala Thr Glu 
                405                 410                 415     


Ile Glu Leu Ala Lys Gln Ile Thr Ser Tyr Gly Glu Thr Cys Pro Gly 
            420                 425                 430         


Leu Glu Gln Tyr Ala Ile Lys Lys Phe Ala Glu Ala Phe Glu Ala Ile 
        435                 440                 445             


Pro Arg Ala Leu Ala Glu Asn Ser Gly Val Lys Ala Asn Glu Val Ile 
    450                 455                 460                 


Ser Lys Leu Tyr Ala Val His Gln Glu Gly Asn Lys Asn Val Gly Leu 
465                 470                 475                 480 


Asp Ile Glu Ala Glu Val Pro Ala Val Lys Asp Met Leu Glu Ala Gly 
                485                 490                 495     


Ile Leu Asp Thr Tyr Leu Gly Lys Tyr Trp Ala Ile Lys Leu Ala Thr 
            500                 505                 510         


Asn Ala Ala Val Thr Val Leu Arg Val Asp Gln Ile Ile Met Ala Lys 
        515                 520                 525             


Pro Ala Gly Gly Pro Lys Pro Pro Ser Gly Lys Lys Asp Trp Asp Asp 
    530                 535                 540                 


Asp Gln Asn Asp 
545             


<210> 5102
<211> 229
<212> PRT
<213> Homo sapiens

<400> 5102
Met Asn Ile Arg Asn Ala Gln Pro Asp Asp Leu Met Asn Met Gln His 
1               5                   10                  15      


Cys Asn Leu Leu Cys Leu Pro Glu Asn Tyr Gln Met Lys Tyr Tyr Leu 
            20                  25                  30          


Tyr His Gly Leu Ser Trp Pro Gln Leu Ser Tyr Ile Ala Glu Asp Glu 
        35                  40                  45              


Asp Gly Lys Ile Val Gly Tyr Val Leu Ala Lys Met Glu Glu Glu Pro 
    50                  55                  60                  


Asp Asp Val Pro His Gly His Ile Thr Ser Leu Ala Val Lys Arg Ser 
65                  70                  75                  80  


His Arg Arg Leu Gly Leu Ala Gln Lys Leu Met Asp Gln Ala Ser Arg 
                85                  90                  95      


Ala Met Ile Glu Asn Phe Asn Ala Lys Tyr Val Ser Leu His Val Arg 
            100                 105                 110         


Lys Ser Asn Arg Pro Ala Leu His Leu Tyr Ser Asn Thr Leu Asn Phe 
        115                 120                 125             


Gln Ile Ser Glu Val Glu Pro Lys Tyr Tyr Ala Asp Gly Glu Asp Ala 
    130                 135                 140                 


Tyr Ala Met Lys Arg Asp Leu Ser Gln Met Ala Asp Glu Leu Arg Arg 
145                 150                 155                 160 


Gln Met Asp Leu Lys Lys Gly Gly Tyr Val Val Leu Gly Ser Arg Glu 
                165                 170                 175     


Asn Gln Glu Thr Gln Gly Ser Thr Leu Ser Asp Ser Glu Glu Ala Cys 
            180                 185                 190         


Gln Gln Lys Asn Pro Ala Thr Glu Glu Ser Gly Ser Asp Ser Lys Glu 
        195                 200                 205             


Pro Lys Glu Ser Val Glu Ser Thr Asn Val Gln Asp Ser Ser Glu Ser 
    210                 215                 220                 


Ser Asp Ser Thr Ser 
225                 


<210> 5103
<211> 457
<212> PRT
<213> Homo sapiens

<400> 5103
Met Ser Ala Leu Arg Arg Ser Gly Tyr Gly Pro Ser Asp Gly Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Tyr Tyr Gly Pro Gly Gly Gly Asp Val Pro Val His Pro 
            20                  25                  30          


Pro Pro Pro Leu Tyr Pro Leu Arg Pro Glu Pro Pro Gln Pro Pro Ile 
        35                  40                  45              


Ser Trp Arg Val Arg Gly Gly Gly Pro Ala Glu Thr Thr Trp Leu Gly 
    50                  55                  60                  


Glu Gly Gly Gly Gly Asp Gly Tyr Tyr Pro Ser Gly Gly Ala Trp Pro 
65                  70                  75                  80  


Glu Pro Gly Arg Ala Gly Gly Ser His Gln Glu Gln Pro Pro Tyr Pro 
                85                  90                  95      


Ser Tyr Asn Ser Asn Tyr Trp Asn Ser Thr Ala Arg Ser Arg Ala Pro 
            100                 105                 110         


Tyr Pro Ser Thr Tyr Pro Val Arg Pro Glu Leu Gln Gly Gln Ser Leu 
        115                 120                 125             


Asn Ser Tyr Thr Asn Gly Ala Tyr Gly Pro Thr Tyr Pro Pro Gly Pro 
    130                 135                 140                 


Gly Ala Asn Thr Ala Ser Tyr Ser Gly Ala Tyr Tyr Ala Pro Gly Tyr 
145                 150                 155                 160 


Thr Gln Thr Ser Tyr Ser Thr Glu Val Pro Ser Thr Tyr Arg Ser Ser 
                165                 170                 175     


Gly Asn Ser Pro Thr Pro Val Ser Arg Trp Ile Tyr Pro Gln Gln Asp 
            180                 185                 190         


Cys Gln Thr Glu Ala Pro Pro Leu Arg Gly Gln Val Pro Gly Tyr Pro 
        195                 200                 205             


Pro Ser Gln Asn Pro Gly Met Thr Leu Pro His Tyr Pro Tyr Gly Asp 
    210                 215                 220                 


Gly Asn Arg Ser Val Pro Gln Ser Gly Pro Thr Val Arg Pro Gln Glu 
225                 230                 235                 240 


Asp Ala Trp Ala Ser Pro Gly Ala Tyr Gly Met Gly Gly Arg Tyr Pro 
                245                 250                 255     


Trp Pro Ser Ser Ala Pro Ser Ala Pro Pro Gly Asn Leu Tyr Met Thr 
            260                 265                 270         


Glu Ser Thr Ser Pro Trp Pro Ser Ser Gly Ser Pro Gln Ser Pro Pro 
        275                 280                 285             


Ser Pro Pro Val Gln Gln Pro Lys Asp Ser Ser Tyr Pro Tyr Ser Gln 
    290                 295                 300                 


Ser Asp Gln Ser Met Asn Arg His Asn Phe Pro Cys Ser Val His Gln 
305                 310                 315                 320 


Tyr Glu Ser Ser Gly Thr Val Asn Asn Asp Asp Ser Asp Leu Leu Asp 
                325                 330                 335     


Ser Gln Val Gln Tyr Ser Ala Glu Pro Gln Leu Tyr Gly Asn Ala Thr 
            340                 345                 350         


Ser Asp His Pro Asn Asn Gln Asp Gln Ser Ser Ser Leu Pro Glu Glu 
        355                 360                 365             


Cys Val Pro Ser Asp Glu Ser Thr Pro Pro Ser Ile Lys Lys Ile Ile 
    370                 375                 380                 


His Val Leu Glu Lys Val Gln Tyr Leu Glu Gln Glu Val Glu Glu Phe 
385                 390                 395                 400 


Val Gly Lys Lys Thr Asp Lys Ala Tyr Trp Leu Leu Glu Glu Met Leu 
                405                 410                 415     


Thr Lys Glu Leu Leu Glu Leu Asp Ser Val Glu Thr Gly Gly Gln Asp 
            420                 425                 430         


Ser Val Arg Gln Ala Arg Lys Glu Ala Val Cys Lys Ile Gln Ala Ile 
        435                 440                 445             


Leu Glu Lys Leu Glu Lys Lys Gly Leu 
    450                 455         


<210> 5104
<211> 1066
<212> PRT
<213> Homo sapiens

<400> 5104
Met Gln Ser Thr Asp Leu Gly Asn Lys Glu Ser Gly Lys Ile Trp His 
1               5                   10                  15      


Arg Lys Pro Ser Pro Ala Thr Arg Asp Gly Ile Ile Val Asn Ile Ile 
            20                  25                  30          


His Asn Thr Ser Asp Tyr His Pro Lys Val Leu Arg Phe Leu Asn Val 
        35                  40                  45              


Ala Phe Asp Gly Thr Gly Asp Cys Leu Ile Ala Gly Asp His Gln Gly 
    50                  55                  60                  


Asn Ile Tyr Val Phe Asp Leu His Gly Asn Arg Phe Asn Leu Val Gln 
65                  70                  75                  80  


Arg Thr Ala Gln Ala Cys Thr Ala Leu Ala Phe Asn Leu Arg Arg Lys 
                85                  90                  95      


Ser Glu Phe Leu Val Ala Leu Ala Asp Tyr Ser Ile Lys Cys Phe Asp 
            100                 105                 110         


Thr Val Thr Lys Glu Leu Val Ser Trp Met Arg Gly His Glu Ser Ser 
        115                 120                 125             


Val Phe Ser Ile Ser Val His Ala Ser Gly Lys Tyr Ala Ile Thr Thr 
    130                 135                 140                 


Ser Ser Asp Thr Ala Gln Leu Trp Asp Leu Asp Thr Phe Gln Arg Lys 
145                 150                 155                 160 


Arg Lys Leu Asn Ile Arg Gln Ser Val Gly Ile Gln Lys Val Phe Phe 
                165                 170                 175     


Leu Pro Leu Ser Asn Thr Ile Leu Ser Cys Phe Lys Asp Asn Ser Ile 
            180                 185                 190         


Phe Ala Trp Glu Cys Asp Thr Leu Phe Cys Lys Tyr Gln Leu Pro Ala 
        195                 200                 205             


Pro Pro Glu Ser Ser Ser Ile Leu Tyr Lys Val Phe Ala Val Thr Arg 
    210                 215                 220                 


Asp Gly Arg Ile Leu Ala Ala Gly Gly Lys Ser Asn His Leu His Leu 
225                 230                 235                 240 


Trp Cys Leu Glu Ala Arg Gln Leu Phe Arg Ile Ile Gln Met Pro Thr 
                245                 250                 255     


Lys Val Arg Ala Ile Arg His Leu Glu Phe Leu Pro Asp Ser Phe Asp 
            260                 265                 270         


Ala Gly Ser Asn Gln Val Leu Gly Val Leu Ser Gln Asp Gly Ile Met 
        275                 280                 285             


Arg Phe Ile Asn Met Gln Thr Cys Lys Leu Leu Phe Glu Ile Gly Ser 
    290                 295                 300                 


Leu Asp Glu Gly Ile Ser Ser Ser Ala Ile Ser Pro His Gly Arg Tyr 
305                 310                 315                 320 


Ile Ala Ser Ile Met Glu Asn Gly Ser Leu Asn Ile Tyr Ser Val Gln 
                325                 330                 335     


Ala Leu Thr Gln Glu Ile Asn Lys Pro Pro Pro Pro Leu Val Lys Val 
            340                 345                 350         


Ile Glu Asp Leu Pro Lys Asn Lys Leu Ser Ser Ser Asp Leu Lys Met 
        355                 360                 365             


Lys Val Thr Ser Gly Arg Val Gln Gln Pro Ala Lys Ser Arg Glu Ser 
    370                 375                 380                 


Lys Met Gln Thr Arg Ile Leu Lys Gln Asp Leu Thr Gly Asp Phe Glu 
385                 390                 395                 400 


Ser Lys Lys Asn Glu Leu Pro Asp Gly Leu Asn Lys Lys Arg Leu Gln 
                405                 410                 415     


Ile Leu Leu Lys Gly Tyr Gly Glu Tyr Pro Thr Lys Tyr Arg Met Phe 
            420                 425                 430         


Ile Trp Arg Ser Leu Leu Gln Leu Pro Glu Asn His Thr Ala Phe Ser 
        435                 440                 445             


Thr Leu Ile Asp Lys Gly Thr His Val Ala Phe Leu Asn Leu Gln Lys 
    450                 455                 460                 


Lys Tyr Pro Ile Lys Ser Arg Lys Leu Leu Arg Val Leu Gln Arg Thr 
465                 470                 475                 480 


Leu Ser Ala Leu Ala His Trp Ser Val Ile Phe Ser Asp Thr Pro Tyr 
                485                 490                 495     


Leu Pro Leu Leu Ala Phe Pro Phe Val Lys Leu Phe Gln Asn Asn Gln 
            500                 505                 510         


Leu Ile Cys Phe Glu Val Ile Ala Thr Leu Ile Ile Asn Trp Cys Gln 
        515                 520                 525             


His Trp Phe Glu Tyr Phe Pro Asn Pro Pro Ile Asn Ile Leu Ser Met 
    530                 535                 540                 


Ile Glu Asn Val Leu Ala Phe His Asp Lys Glu Leu Leu Gln His Phe 
545                 550                 555                 560 


Ile Asp His Asp Ile Thr Ser Gln Leu Tyr Ala Trp Pro Leu Leu Glu 
                565                 570                 575     


Thr Val Phe Ser Glu Val Leu Thr Arg Glu Glu Trp Leu Lys Leu Phe 
            580                 585                 590         


Asp Asn Ile Phe Ser Asn His Pro Ser Phe Leu Leu Met Thr Val Val 
        595                 600                 605             


Ala Tyr Asn Ile Cys Ser Arg Thr Pro Leu Leu Ser Cys Asn Leu Lys 
    610                 615                 620                 


Asp Asp Phe Glu Phe Phe Phe His His Arg Asn Asn Leu Asp Ile Asn 
625                 630                 635                 640 


Val Val Ile Arg Gln Val Tyr His Leu Met Glu Thr Thr Pro Thr Asp 
                645                 650                 655     


Ile His Pro Asp Ser Met Leu Asn Val Phe Val Ala Leu Thr Lys Gly 
            660                 665                 670         


Gln Tyr Pro Val Phe Asn Gln Tyr Pro Lys Phe Ile Val Asp Tyr Gln 
        675                 680                 685             


Thr Gln Glu Arg Glu Arg Ile Arg Asn Asp Glu Leu Asp Tyr Leu Arg 
    690                 695                 700                 


Glu Arg Gln Thr Val Glu Asp Met Gln Ala Lys Val Asp Gln Gln Arg 
705                 710                 715                 720 


Val Glu Asp Glu Ala Trp Tyr Gln Lys Gln Glu Leu Leu Arg Lys Ala 
                725                 730                 735     


Glu Glu Thr Arg Arg Glu Met Leu Leu Gln Glu Glu Glu Lys Met Ile 
            740                 745                 750         


Gln Gln Arg Gln Arg Leu Ala Ala Val Lys Arg Glu Leu Lys Val Lys 
        755                 760                 765             


Glu Met His Leu Gln Asp Ala Ala Arg Arg Arg Phe Leu Lys Leu Gln 
    770                 775                 780                 


Gln Asp Gln Gln Glu Met Glu Leu Arg Arg Leu Asp Asp Glu Ile Gly 
785                 790                 795                 800 


Arg Lys Val Tyr Met Arg Asp Arg Glu Ile Ala Ala Thr Ala Arg Asp 
                805                 810                 815     


Leu Glu Met Arg Gln Leu Glu Leu Glu Ser Gln Lys Arg Leu Tyr Glu 
            820                 825                 830         


Lys Asn Leu Thr Glu Asn Gln Glu Ala Leu Ala Lys Glu Met Arg Ala 
        835                 840                 845             


Asp Ala Asp Ala Tyr Arg Arg Lys Val Asp Leu Glu Glu His Met Phe 
    850                 855                 860                 


His Lys Leu Ile Glu Ala Gly Glu Thr Gln Ser Gln Lys Thr Gln Lys 
865                 870                 875                 880 


Val Ile Lys Glu Asn Leu Ala Lys Ala Glu Gln Ala Cys Leu Asn Thr 
                885                 890                 895     


Asp Trp Gln Ile Gln Ser Leu His Lys Gln Lys Cys Asp Asp Leu Gln 
            900                 905                 910         


Arg Asn Lys Cys Tyr Gln Glu Val Ala Lys Leu Leu Arg Glu Asn Arg 
        915                 920                 925             


Arg Lys Glu Ile Glu Ile Ile Asn Ala Met Val Glu Glu Glu Ala Lys 
    930                 935                 940                 


Lys Trp Lys Glu Ala Glu Gly Lys Glu Phe Arg Leu Arg Ser Ala Lys 
945                 950                 955                 960 


Lys Ala Ser Ala Leu Ser Asp Ala Ser Arg Lys Trp Phe Leu Lys Gln 
                965                 970                 975     


Glu Ile Asn Ala Ala Val Glu His Ala Glu Asn Pro Cys His Lys Glu 
            980                 985                 990         


Glu Pro Arg Phe Gln Asn Glu Gln  Asp Ser Ser Cys Leu  Pro Arg Thr 
        995                 1000                 1005             


Ser Gln  Leu Asn Asp Ser Ser  Glu Met Asp Pro Ser  Thr Gln Ile 
    1010                 1015                 1020             


Ser Leu  Asn Arg Arg Ala Val  Glu Trp Asp Thr Thr  Gly Gln Asn 
    1025                 1030                 1035             


Leu Ile  Lys Lys Val Arg Asn  Leu Arg Gln Arg Leu  Thr Ala Arg 
    1040                 1045                 1050             


Ala Arg  His Arg Cys Gln Thr  Pro His Leu Leu Ala  Ala 
    1055                 1060                 1065     


<210> 5105
<211> 205
<212> PRT
<213> Homo sapiens

<400> 5105
Met Glu Gly Asn Gly Pro Ala Ala Val His Tyr Gln Pro Ala Ser Pro 
1               5                   10                  15      


Pro Arg Asp Ala Cys Val Tyr Ser Ser Cys Tyr Cys Glu Glu Asn Ile 
            20                  25                  30          


Trp Lys Leu Cys Glu Tyr Ile Lys Asn His Asp Gln Tyr Pro Leu Glu 
        35                  40                  45              


Glu Cys Tyr Ala Val Phe Ile Ser Asn Glu Arg Lys Met Ile Pro Ile 
    50                  55                  60                  


Trp Lys Gln Gln Ala Arg Pro Gly Asp Gly Pro Val Ile Trp Asp Tyr 
65                  70                  75                  80  


His Val Val Leu Leu His Val Ser Ser Gly Gly Gln Asn Phe Ile Tyr 
                85                  90                  95      


Asp Leu Asp Thr Val Leu Pro Phe Pro Cys Leu Phe Asp Thr Tyr Val 
            100                 105                 110         


Glu Asp Ala Phe Lys Ser Asp Asp Asp Ile His Pro Gln Phe Arg Arg 
        115                 120                 125             


Lys Phe Arg Val Ile Arg Ala Asp Ser Tyr Leu Lys Asn Phe Ala Ser 
    130                 135                 140                 


Asp Arg Ser His Met Lys Asp Ser Ser Gly Asn Trp Arg Glu Pro Pro 
145                 150                 155                 160 


Pro Pro Tyr Pro Cys Ile Glu Thr Gly Asp Ser Lys Met Asn Leu Asn 
                165                 170                 175     


Asp Phe Ile Ser Met Asp Pro Lys Val Gly Trp Gly Ala Val Tyr Thr 
            180                 185                 190         


Leu Ser Glu Phe Thr His Arg Phe Gly Ser Lys Asn Cys 
        195                 200                 205 


<210> 5106
<211> 657
<212> PRT
<213> Homo sapiens

<400> 5106
Met Ser Gln Val Leu Phe His Gln Leu Val Pro Leu Gln Val Lys Cys 
1               5                   10                  15      


Lys Asp Cys Glu Glu Arg Arg Val Ser Ile Arg Met Ser Ile Glu Leu 
            20                  25                  30          


Gln Ser Val Ser Asn Pro Val His Arg Lys Asp Leu Val Ile Arg Leu 
        35                  40                  45              


Thr Asp Asp Thr Asp Pro Phe Phe Leu Tyr Asn Leu Val Ile Ser Glu 
    50                  55                  60                  


Glu Asp Phe Gln Ser Leu Lys Phe Gln Gln Gly Leu Leu Val Asp Phe 
65                  70                  75                  80  


Leu Ala Phe Pro Gln Lys Phe Ile Asp Leu Leu Gln Gln Cys Thr Gln 
                85                  90                  95      


Glu His Ala Lys Glu Ile Pro Arg Phe Leu Leu Gln Leu Val Ser Pro 
            100                 105                 110         


Ala Ala Ile Leu Asp Asn Ser Pro Ala Phe Leu Asn Val Val Glu Thr 
        115                 120                 125             


Asn Pro Phe Lys His Leu Thr His Leu Ser Leu Lys Leu Leu Pro Gly 
    130                 135                 140                 


Asn Asp Val Glu Ile Lys Lys Phe Leu Ala Gly Cys Leu Lys Cys Ser 
145                 150                 155                 160 


Lys Glu Glu Lys Leu Ser Leu Met Gln Ser Leu Asp Asp Ala Thr Lys 
                165                 170                 175     


Gln Leu Asp Phe Thr Arg Lys Thr Leu Ala Glu Lys Lys Gln Glu Leu 
            180                 185                 190         


Asp Lys Leu Arg Asn Glu Trp Ala Ser His Thr Ala Ala Leu Thr Asn 
        195                 200                 205             


Lys His Ser Gln Glu Leu Thr Asn Glu Lys Glu Lys Ala Leu Gln Ala 
    210                 215                 220                 


Gln Val Gln Tyr Gln Gln Gln His Glu Gln Gln Lys Lys Asp Leu Glu 
225                 230                 235                 240 


Ile Leu His Gln Gln Asn Ile His Gln Leu Gln Asn Arg Leu Ser Glu 
                245                 250                 255     


Leu Glu Ala Ala Asn Lys Asp Leu Thr Glu Arg Lys Tyr Lys Gly Asp 
            260                 265                 270         


Ser Thr Ile Arg Glu Leu Lys Ala Lys Leu Ser Gly Val Glu Glu Glu 
        275                 280                 285             


Leu Gln Arg Thr Lys Gln Glu Val Leu Ser Leu Arg Arg Glu Asn Ser 
    290                 295                 300                 


Thr Leu Asp Val Glu Cys His Glu Lys Glu Lys His Val Asn Gln Leu 
305                 310                 315                 320 


Gln Thr Lys Val Ala Val Leu Glu Gln Glu Ile Lys Asp Lys Asp Gln 
                325                 330                 335     


Leu Val Leu Arg Thr Lys Glu Ala Phe Asp Thr Ile Gln Glu Gln Lys 
            340                 345                 350         


Val Val Leu Glu Glu Asn Gly Glu Lys Asn Gln Val Gln Leu Gly Lys 
        355                 360                 365             


Leu Glu Ala Thr Ile Lys Ser Leu Ser Ala Glu Leu Leu Lys Ala Asn 
    370                 375                 380                 


Glu Ile Ile Lys Lys Leu Gln Gly Asp Leu Lys Thr Leu Met Gly Lys 
385                 390                 395                 400 


Leu Lys Leu Lys Asn Thr Val Thr Ile Gln Gln Glu Lys Leu Leu Ala 
                405                 410                 415     


Glu Lys Glu Glu Lys Leu Gln Lys Glu Gln Lys Glu Leu Gln Asp Val 
            420                 425                 430         


Gly Gln Ser Leu Arg Ile Lys Glu Gln Glu Val Cys Lys Leu Gln Glu 
        435                 440                 445             


Gln Leu Glu Ala Thr Val Lys Lys Leu Glu Glu Ser Lys Gln Leu Leu 
    450                 455                 460                 


Lys Asn Asn Glu Lys Leu Ile Thr Trp Leu Asn Lys Glu Leu Asn Glu 
465                 470                 475                 480 


Asn Gln Leu Val Arg Lys Gln Asp Val Leu Gly Pro Ser Thr Thr Pro 
                485                 490                 495     


Pro Ala His Ser Ser Ser Asn Thr Ile Arg Ser Gly Ile Ser Pro Asn 
            500                 505                 510         


Leu Asn Val Val Asp Gly Arg Leu Thr Tyr Pro Thr Cys Gly Ile Gly 
        515                 520                 525             


Tyr Pro Val Ser Ser Ala Phe Ala Phe Gln Asn Thr Phe Pro His Ser 
    530                 535                 540                 


Ile Ser Ala Lys Asn Thr Ser His Pro Gly Ser Gly Thr Lys Val Gln 
545                 550                 555                 560 


Phe Asn Leu Gln Phe Thr Lys Pro Asn Ala Ser Leu Gly Asp Val Gln 
                565                 570                 575     


Ser Gly Ala Thr Ile Ser Met Pro Cys Ser Thr Asp Lys Glu Asn Gly 
            580                 585                 590         


Glu Asn Val Gly Leu Glu Ser Lys Tyr Leu Lys Lys Arg Glu Asp Ser 
        595                 600                 605             


Ile Pro Leu Arg Gly Leu Ser Gln Asn Leu Phe Ser Asn Ser Asp His 
    610                 615                 620                 


Gln Arg Asp Gly Thr Leu Gly Ala Leu His Thr Ser Ser Lys Pro Thr 
625                 630                 635                 640 


Ala Leu Pro Ser Ala Ser Ser Ala Tyr Phe Pro Gly Gln Leu Pro Asn 
                645                 650                 655     


Ser 
    


<210> 5107
<211> 78
<212> PRT
<213> Homo sapiens

<400> 5107
Met Arg Phe Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg 
1               5                   10                  15      


Lys Pro Val Glu Gly Tyr Asp Ile Ser Phe Leu Ile Thr Asn Phe His 
            20                  25                  30          


Thr Glu Gln Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe 
        35                  40                  45              


Met Glu Glu Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn 
    50                  55                  60                  


Ala Arg Ala Arg Ile Val Ala Glu Glu Phe Leu Lys Asn Phe 
65                  70                  75              


<210> 5108
<211> 310
<212> PRT
<213> Homo sapiens

<400> 5108
Met Pro Leu Leu Val Glu Gly Arg Arg Val Arg Leu Pro Gln Ser Ala 
1               5                   10                  15      


Gly Asp Leu Val Arg Ala His Pro Pro Leu Glu Glu Arg Ala Arg Leu 
            20                  25                  30          


Leu Arg Gly Gln Ser Val Gln Gln Val Gly Pro Gln Gly Leu Leu Tyr 
        35                  40                  45              


Val Gln Gln Arg Glu Leu Ala Val Thr Ser Pro Lys Asp Gly Ser Ile 
    50                  55                  60                  


Ser Ile Leu Gly Ser Asp Asp Ala Thr Thr Cys His Ile Val Val Leu 
65                  70                  75                  80  


Arg His Thr Gly Asn Gly Ala Thr Cys Leu Thr His Cys Asp Gly Thr 
                85                  90                  95      


Asp Thr Lys Ala Glu Val Pro Leu Ile Met Asn Ser Ile Lys Ser Phe 
            100                 105                 110         


Ser Asp His Ala Gln Cys Gly Arg Leu Glu Val His Leu Val Gly Gly 
        115                 120                 125             


Phe Ser Asp Asp Arg Gln Leu Ser Gln Lys Leu Thr His Gln Leu Leu 
    130                 135                 140                 


Ser Glu Phe Asp Arg Gln Glu Asp Asp Ile His Leu Val Thr Leu Cys 
145                 150                 155                 160 


Val Thr Glu Leu Asn Asp Arg Glu Glu Asn Glu Asn His Phe Pro Val 
                165                 170                 175     


Ile Tyr Gly Ile Ala Val Asn Ile Lys Thr Ala Glu Ile Tyr Arg Ala 
            180                 185                 190         


Ser Phe Gln Asp Arg Gly Pro Glu Glu Gln Leu Arg Ala Ala Arg Thr 
        195                 200                 205             


Leu Ala Gly Gly Pro Met Ile Ser Ile Tyr Asp Ala Glu Thr Glu Gln 
    210                 215                 220                 


Leu Arg Ile Gly Pro Tyr Ser Trp Thr Pro Phe Pro His Val Asp Phe 
225                 230                 235                 240 


Trp Leu His Gln Asp Asp Lys Gln Ile Leu Glu Asn Leu Ser Thr Ser 
                245                 250                 255     


Pro Leu Ala Glu Pro Pro His Phe Val Glu His Ile Arg Ser Thr Leu 
            260                 265                 270         


Met Phe Leu Lys Lys His Pro Ser Pro Ala His Thr Leu Phe Ser Gly 
        275                 280                 285             


Asn Lys Ala Leu Leu Tyr Lys Lys Asn Glu Asp Gly Leu Trp Glu Lys 
    290                 295                 300                 


Ile Ser Ser Pro Gly Ser 
305                 310 


<210> 5109
<211> 307
<212> PRT
<213> Homo sapiens

<400> 5109
Met Thr Glu Thr Thr Lys Thr His Val Ile Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Lys Gly His Ile Gln Met Phe Glu Arg Ala Arg 
            20                  25                  30          


Asp Tyr Leu His Lys Thr Gly Arg Phe Ile Val Ile Gly Gly Ile Val 
        35                  40                  45              


Ser Pro Val His Asp Ser Tyr Gly Lys Gln Gly Leu Val Ser Ser Arg 
    50                  55                  60                  


His Arg Leu Ile Met Cys Gln Leu Ala Val Gln Asn Ser Asp Trp Ile 
65                  70                  75                  80  


Arg Val Asp Pro Trp Glu Cys Tyr Gln Asp Thr Trp Gln Thr Thr Cys 
                85                  90                  95      


Ser Val Leu Glu His His Arg Asp Leu Met Lys Arg Val Thr Gly Cys 
            100                 105                 110         


Ile Leu Ser Asn Val Asn Thr Pro Ser Met Thr Pro Val Ile Gly Gln 
        115                 120                 125             


Pro Gln Asn Glu Thr Pro Gln Pro Ile Tyr Gln Asn Ser Asn Val Ala 
    130                 135                 140                 


Thr Lys Pro Thr Ala Ala Lys Ile Leu Gly Lys Val Gly Glu Ser Leu 
145                 150                 155                 160 


Ser Arg Ile Cys Cys Val Arg Pro Pro Val Glu Arg Phe Thr Phe Val 
                165                 170                 175     


Asp Glu Asn Ala Asn Leu Gly Thr Val Met Arg Tyr Glu Glu Ile Glu 
            180                 185                 190         


Leu Arg Ile Leu Leu Leu Cys Gly Ser Asp Leu Leu Glu Ser Phe Cys 
        195                 200                 205             


Ile Pro Gly Leu Trp Asn Glu Ala Asp Met Glu Val Ile Val Gly Asp 
    210                 215                 220                 


Phe Gly Ile Val Val Val Pro Arg Asp Ala Ala Asp Thr Asp Arg Ile 
225                 230                 235                 240 


Met Asn His Ser Ser Ile Leu Arg Lys Tyr Lys Asn Asn Ile Met Val 
                245                 250                 255     


Val Lys Asp Asp Ile Asn His Pro Met Ser Val Val Ser Ser Thr Lys 
            260                 265                 270         


Ser Arg Leu Ala Leu Gln His Gly Asp Gly His Val Val Asp Tyr Leu 
        275                 280                 285             


Ser Gln Pro Val Ile Asp Tyr Ile Leu Lys Ser Gln Leu Tyr Ile Asn 
    290                 295                 300                 


Ala Ser Gly 
305         


<210> 5110
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5110
Met Glu Glu Gly Lys Met Asp Glu Asn Glu Trp Gly Tyr His Gly Glu 
1               5                   10                  15      


Gly Asn Lys Ser Leu Val Val Ala His Ala Gln Arg Cys Val Val Leu 
            20                  25                  30          


Arg Phe Leu Lys Phe Pro Pro Asn Arg Lys Lys Thr Ser Glu Glu Ile 
        35                  40                  45              


Phe Gln His Leu Gln Asn Ile Val Asp Phe Gly Lys Asn Val Met Lys 
    50                  55                  60                  


Glu Phe Leu Gly Glu Asn Tyr Val His Tyr Gly Glu Val Val Gln Leu 
65                  70                  75                  80  


Pro Leu Glu Phe Val Lys Gln Leu Cys Leu Lys Ile Gln Ser Glu Arg 
                85                  90                  95      


Pro Glu Ser Arg Cys Asp Lys Asp Leu Asp Thr Leu Ser Gly Tyr Ala 
            100                 105                 110         


Met Cys Leu Pro Asn Leu Thr Arg Leu Gln Thr Tyr Arg Phe Ala Glu 
        115                 120                 125             


His Arg Pro Ile Leu Cys Val Glu Ile Lys Pro Lys Cys Gly Phe Ile 
    130                 135                 140                 


Pro Phe Ser Ser Asp Val Thr His Glu Met Lys His Lys Val Cys Arg 
145                 150                 155                 160 


Tyr Cys Met His Gln His Leu Lys Val Ala Thr Gly Lys Trp Lys Gln 
                165                 170                 175     


Ile Ser Lys Tyr Cys Pro Leu Asp Leu Tyr Ser Gly Asn Lys Gln Arg 
            180                 185                 190         


Met His Phe Ala Leu Lys Ser Leu Leu Gln Glu Ala Gln Asn Asn Leu 
        195                 200                 205             


Lys Ile Phe Lys Asn Gly Glu Leu Ile Tyr Gly Cys Lys Asp Ala Arg 
    210                 215                 220                 


Ser Pro Val Ala Asp Trp Ser Glu Leu Ala His His Leu Lys Pro Phe 
225                 230                 235                 240 


Phe Phe Pro Ser Asn Gly Leu Ala Ser Gly Pro His Cys Thr Arg Ala 
                245                 250                 255     


Val Ile Arg Glu Leu Val His Val Ile Thr Arg Val Leu Leu Ser Gly 
            260                 265                 270         


Ser Asp Lys Gly Arg Ala Gly Thr Leu Ser Pro Gly Leu Gly Pro Gln 
        275                 280                 285             


Gly Pro Arg Val Cys Glu Ala Ser Pro Phe Ser Arg Ser Leu Arg Cys 
    290                 295                 300                 


Gln Gly Lys Asn Thr Pro Glu Arg Ser Gly Leu Pro Lys Gly Cys Leu 
305                 310                 315                 320 


Leu Tyr Lys Thr Leu Gln Val Gln Met Leu Asp Leu Leu Asp Ile Glu 
                325                 330                 335     


Gly Leu Tyr Pro Leu Tyr Asn Arg Val Glu Arg Tyr Leu Glu Glu Phe 
            340                 345                 350         


Pro Glu Glu Arg Lys Thr Leu Gln Ile Asp Gly Pro Tyr Asp Glu Ala 
        355                 360                 365             


Phe Tyr Gln Lys Leu Leu Asp Leu Ser Thr Glu Asp Asp Gly Thr Val 
    370                 375                 380                 


Ala Phe Ala Leu Thr Lys Val Gln Gln Tyr Arg Val Ala Met Thr Ala 
385                 390                 395                 400 


Lys Asp Cys Ser Ile Met Ile Ala Leu Ser Pro Cys Leu Gln Asp Ala 
                405                 410                 415     


Ser Ser Asp Gln Arg Pro Val Val Pro Ser Ser Arg Ser Arg Phe Ala 
            420                 425                 430         


Phe Ser Val Ser Val Leu Asp Leu Asp Leu Lys Pro Tyr Glu Ser Ile 
        435                 440                 445             


Pro His Gln Tyr Lys Leu Asp Gly Lys Ile Val Asn Tyr Tyr Ser Lys 
    450                 455                 460                 


Thr Val Arg Ala Lys Asp Asn Ala Val Met Ser Thr Arg Phe Lys Glu 
465                 470                 475                 480 


Ser Glu Asp Cys Thr Leu Val Leu His Lys Val 
                485                 490     


<210> 5111
<211> 879
<212> PRT
<213> Homo sapiens

<400> 5111
Met Met Phe Tyr Arg Leu Leu Ser Ile Val Gly Arg Gln Arg Ala Ser 
1               5                   10                  15      


Pro Gly Trp Gln Asn Trp Ser Ser Ala Arg Asn Ser Thr Ser Ala Ala 
            20                  25                  30          


Glu Ala Arg Ser Met Ala Leu Pro Thr Gln Ala Gln Val Val Ile Cys 
        35                  40                  45              


Gly Gly Gly Ile Thr Gly Thr Ser Val Ala Tyr His Leu Ser Lys Met 
    50                  55                  60                  


Gly Trp Lys Asp Ile Val Leu Leu Glu Gln Gly Arg Leu Ala Ala Gly 
65                  70                  75                  80  


Ser Thr Arg Phe Cys Ala Gly Ile Leu Ser Thr Ala Arg His Leu Thr 
                85                  90                  95      


Ile Glu Gln Lys Met Ala Asp Tyr Ser Asn Lys Leu Tyr Tyr Gln Leu 
            100                 105                 110         


Glu Gln Glu Thr Gly Ile Gln Thr Gly Tyr Thr Arg Thr Gly Ser Ile 
        115                 120                 125             


Phe Leu Ala Gln Thr Gln Asp Arg Leu Ile Ser Leu Lys Arg Ile Asn 
    130                 135                 140                 


Ala Gly Leu Asn Val Ile Gly Ile Pro Ser Glu Ile Ile Ser Pro Lys 
145                 150                 155                 160 


Lys Val Ala Glu Leu His His Leu Leu Asn Val His Asp Leu Val Gly 
                165                 170                 175     


Ala Met His Val Pro Glu Asp Ala Val Val Ser Ser Ala Asp Val Ala 
            180                 185                 190         


Leu Ala Leu Ala Ser Ala Ala Ser Gln Asn Gly Val Gln Ile Tyr Asp 
        195                 200                 205             


Arg Thr Ser Val Leu His Val Met Val Lys Lys Gly Gln Val Thr Gly 
    210                 215                 220                 


Val Glu Thr Asp Lys Gly Gln Ile Glu Cys Gln Tyr Phe Val Asn Cys 
225                 230                 235                 240 


Ala Gly Gln Trp Ala Tyr Glu Leu Gly Leu Ser Asn Glu Glu Pro Val 
                245                 250                 255     


Ser Ile Pro Leu His Ala Cys Glu His Phe Tyr Leu Leu Thr Arg Pro 
            260                 265                 270         


Leu Glu Thr Pro Leu Gln Ser Ser Thr Pro Thr Ile Val Asp Ala Asp 
        275                 280                 285             


Gly Arg Ile Tyr Ile Arg Asn Trp Gln Gly Gly Ile Leu Ser Gly Gly 
    290                 295                 300                 


Phe Glu Lys Asn Pro Lys Pro Ile Phe Thr Glu Gly Lys Asn Gln Leu 
305                 310                 315                 320 


Glu Ile Gln Asn Leu Gln Glu Asp Trp Asp His Phe Glu Pro Leu Leu 
                325                 330                 335     


Ser Ser Leu Leu Arg Arg Met Pro Glu Leu Glu Thr Leu Glu Ile Met 
            340                 345                 350         


Lys Leu Val Asn Cys Pro Glu Thr Phe Thr Pro Asp Met Arg Cys Ile 
        355                 360                 365             


Met Gly Glu Ser Pro Ala Val Gln Gly Tyr Phe Val Leu Ala Gly Met 
    370                 375                 380                 


Asn Ser Ala Gly Leu Ser Phe Gly Gly Gly Ala Gly Lys Tyr Leu Ala 
385                 390                 395                 400 


Glu Trp Met Val His Gly Tyr Pro Ser Glu Asn Val Trp Glu Leu Asp 
                405                 410                 415     


Leu Lys Arg Phe Gly Ala Leu Gln Ser Ser Arg Thr Phe Leu Arg His 
            420                 425                 430         


Arg Val Met Glu Val Met Pro Leu Met Tyr Asp Leu Lys Val Pro Arg 
        435                 440                 445             


Trp Asp Phe Gln Thr Gly Arg Gln Leu Arg Thr Ser Pro Leu Tyr Asp 
    450                 455                 460                 


Arg Leu Asp Ala Gln Gly Ala Arg Trp Met Glu Lys His Gly Phe Glu 
465                 470                 475                 480 


Arg Pro Lys Tyr Phe Val Pro Pro Asp Lys Asp Leu Leu Ala Leu Glu 
                485                 490                 495     


Gln Ser Lys Thr Phe Tyr Lys Pro Asp Trp Phe Asp Ile Val Glu Ser 
            500                 505                 510         


Glu Val Lys Cys Cys Lys Glu Ala Val Cys Val Ile Asp Met Ser Ser 
        515                 520                 525             


Phe Thr Lys Phe Glu Ile Thr Ser Thr Gly Asp Gln Ala Leu Glu Val 
    530                 535                 540                 


Leu Gln Tyr Leu Phe Ser Asn Asp Leu Asp Val Pro Val Gly His Ile 
545                 550                 555                 560 


Val His Thr Gly Met Leu Asn Glu Gly Gly Gly Tyr Glu Asn Asp Cys 
                565                 570                 575     


Ser Ile Ala Arg Leu Asn Lys Arg Ser Phe Phe Met Ile Ser Pro Thr 
            580                 585                 590         


Asp Gln Gln Val His Cys Trp Ala Trp Leu Lys Lys His Met Pro Lys 
        595                 600                 605             


Asp Ser Asn Leu Leu Leu Glu Asp Val Thr Trp Lys Tyr Thr Ala Leu 
    610                 615                 620                 


Asn Leu Ile Gly Pro Arg Ala Val Asp Val Leu Ser Glu Leu Ser Tyr 
625                 630                 635                 640 


Ala Pro Met Thr Pro Asp His Phe Pro Ser Leu Phe Cys Lys Glu Met 
                645                 650                 655     


Ser Val Gly Tyr Ala Asn Gly Ile Arg Val Met Ser Met Thr His Thr 
            660                 665                 670         


Gly Glu Pro Gly Phe Met Leu Tyr Ile Pro Ile Glu Tyr Ala Leu His 
        675                 680                 685             


Val Tyr Asn Glu Val Met Ser Val Gly Gln Lys Tyr Gly Ile Arg Asn 
    690                 695                 700                 


Ala Gly Tyr Tyr Ala Leu Arg Ser Leu Arg Ile Glu Lys Phe Phe Ala 
705                 710                 715                 720 


Phe Trp Gly Gln Asp Ile Asn Asn Leu Thr Thr Pro Leu Glu Cys Gly 
                725                 730                 735     


Arg Glu Ser Arg Val Lys Leu Glu Lys Gly Met Asp Phe Ile Gly Arg 
            740                 745                 750         


Asp Ala Leu Leu Gln Gln Lys Gln Asn Gly Val Tyr Lys Arg Leu Thr 
        755                 760                 765             


Met Phe Ile Leu Asp Asp His Asp Ser Asp Leu Asp Leu Trp Pro Trp 
    770                 775                 780                 


Trp Gly Glu Pro Ile Tyr Arg Asn Gly Gln Tyr Val Gly Lys Thr Thr 
785                 790                 795                 800 


Ser Ser Ala Tyr Ser Tyr Ser Leu Glu Arg His Val Cys Leu Gly Phe 
                805                 810                 815     


Val His Asn Phe Ser Glu Asp Thr Gly Glu Glu Gln Val Val Thr Ala 
            820                 825                 830         


Asp Phe Ile Asn Arg Gly Glu Tyr Glu Ile Asp Ile Ala Gly Tyr Arg 
        835                 840                 845             


Phe Gln Ala Lys Ala Lys Leu Tyr Pro Val Ala Ser Leu Phe Thr Gln 
    850                 855                 860                 


Lys Arg Arg Lys Asp Asp Met Glu Leu Ser Asp Leu His Gly Lys 
865                 870                 875                 


<210> 5112
<211> 479
<212> PRT
<213> Homo sapiens

<400> 5112
Met Ala Thr Asp Ser Trp Ala Leu Ala Val Asp Glu Gln Glu Ala Ala 
1               5                   10                  15      


Ala Glu Ser Leu Ser Asn Leu His Leu Lys Glu Glu Lys Ile Lys Pro 
            20                  25                  30          


Asp Thr Asn Gly Ala Val Val Lys Thr Asn Ala Asn Ala Glu Lys Thr 
        35                  40                  45              


Asp Glu Glu Glu Lys Glu Asp Arg Ala Ala Gln Ser Leu Leu Asn Lys 
    50                  55                  60                  


Leu Ile Arg Ser Asn Leu Val Asp Asn Thr Asn Gln Val Glu Val Leu 
65                  70                  75                  80  


Gln Arg Asp Pro Asn Ser Pro Leu Tyr Ser Val Lys Ser Phe Glu Glu 
                85                  90                  95      


Leu Arg Leu Lys Pro Gln Leu Leu Gln Gly Val Tyr Ala Met Gly Phe 
            100                 105                 110         


Asn Arg Pro Ser Lys Ile Gln Glu Asn Ala Leu Pro Leu Met Leu Ala 
        115                 120                 125             


Glu Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly Thr Gly Lys 
    130                 135                 140                 


Thr Ala Ala Phe Val Leu Ala Met Leu Ser Gln Val Glu Pro Ala Asn 
145                 150                 155                 160 


Lys Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr Tyr Glu Leu Ala Leu 
                165                 170                 175     


Gln Thr Gly Lys Val Ile Glu Gln Met Gly Lys Phe Tyr Pro Glu Leu 
            180                 185                 190         


Lys Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu Glu Arg Gly Gln Lys 
        195                 200                 205             


Ile Ser Glu Gln Ile Val Ile Gly Thr Pro Gly Thr Val Leu Asp Trp 
    210                 215                 220                 


Cys Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys Ile Lys Val Phe Val 
225                 230                 235                 240 


Leu Asp Glu Ala Asp Val Met Ile Ala Thr Gln Gly His Gln Asp Gln 
                245                 250                 255     


Ser Ile Arg Ile Gln Arg Met Leu Pro Arg Asn Cys Gln Met Leu Leu 
            260                 265                 270         


Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Lys Phe Ala Gln Lys Val 
        275                 280                 285             


Val Pro Asp Pro Asn Val Ile Lys Leu Lys Arg Glu Glu Glu Thr Leu 
    290                 295                 300                 


Asp Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser Ser Arg Asp Glu Lys 
305                 310                 315                 320 


Phe Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile Thr Ile Ala Gln Ala 
                325                 330                 335     


Met Ile Phe Cys His Thr Arg Lys Thr Ala Ser Trp Leu Ala Ala Glu 
            340                 345                 350         


Leu Ser Lys Glu Gly His Gln Val Ala Leu Leu Ser Gly Glu Met Met 
        355                 360                 365             


Val Glu Gln Arg Ala Ala Val Ile Glu Arg Phe Arg Glu Gly Lys Glu 
    370                 375                 380                 


Lys Val Leu Val Thr Thr Asn Val Cys Ala Arg Gly Ile Asp Val Glu 
385                 390                 395                 400 


Gln Val Ser Val Val Ile Asn Phe Asp Leu Pro Val Asp Lys Asp Gly 
                405                 410                 415     


Asn Pro Asp Asn Glu Thr Tyr Leu His Arg Ile Gly Arg Thr Gly Arg 
            420                 425                 430         


Phe Gly Lys Arg Gly Leu Ala Val Asn Met Val Asp Ser Lys His Ser 
        435                 440                 445             


Met Asn Ile Leu Asn Arg Ile Gln Glu His Phe Asn Lys Lys Ile Glu 
    450                 455                 460                 


Arg Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu Lys Ile Ala Asn 
465                 470                 475                 


<210> 5113
<211> 1084
<212> PRT
<213> Homo sapiens

<400> 5113
Met Glu Gln Pro Lys Gly Val Asp Trp Thr Val Ile Ile Leu Thr Cys 
1               5                   10                  15      


Gln Tyr Lys Asp Ser Val Gln Val Phe Gln Arg Glu Leu Glu Val Arg 
            20                  25                  30          


Gln Lys Arg Glu Gln Ile Pro Ala Gly Thr Leu Leu Leu Ala Val Glu 
        35                  40                  45              


Asp Pro Glu Lys Arg Val Gly Ser Gly Gly Ala Thr Leu Asn Ala Leu 
    50                  55                  60                  


Leu Val Ala Ala Glu His Leu Ser Ala Arg Ala Gly Phe Thr Val Val 
65                  70                  75                  80  


Thr Ser Asp Val Leu His Ser Ala Trp Ile Leu Ile Leu His Met Gly 
                85                  90                  95      


Arg Asp Phe Pro Phe Asp Asp Cys Gly Arg Ala Phe Thr Cys Leu Pro 
            100                 105                 110         


Val Glu Asn Pro Glu Ala Pro Val Glu Ala Leu Val Cys Asn Leu Asp 
        115                 120                 125             


Cys Leu Leu Asp Ile Met Thr Tyr Arg Leu Gly Pro Gly Ser Pro Pro 
    130                 135                 140                 


Gly Val Trp Val Cys Ser Thr Asp Met Leu Leu Ser Val Pro Ala Asn 
145                 150                 155                 160 


Pro Gly Ile Ser Trp Asp Ser Phe Arg Gly Ala Arg Val Ile Ala Leu 
                165                 170                 175     


Pro Gly Ser Pro Ala Tyr Ala Gln Asn His Gly Val Tyr Leu Thr Asp 
            180                 185                 190         


Pro Gln Gly Leu Val Leu Asp Ile Tyr Tyr Gln Gly Thr Glu Ala Glu 
        195                 200                 205             


Ile Gln Arg Cys Val Arg Pro Asp Gly Arg Val Pro Leu Val Ser Gly 
    210                 215                 220                 


Val Val Phe Phe Ser Val Glu Thr Ala Glu Arg Leu Leu Ala Thr His 
225                 230                 235                 240 


Val Ser Pro Pro Leu Asp Ala Cys Thr Tyr Leu Gly Leu Asp Ser Gly 
                245                 250                 255     


Ala Arg Pro Val Gln Leu Ser Leu Phe Phe Asp Ile Leu His Cys Met 
            260                 265                 270         


Ala Glu Asn Val Thr Arg Glu Asp Phe Leu Val Gly Arg Pro Pro Glu 
        275                 280                 285             


Leu Gly Gln Gly Asp Ala Asp Val Ala Gly Tyr Leu Gln Ser Ala Arg 
    290                 295                 300                 


Ala Gln Leu Trp Arg Glu Leu Arg Asp Gln Pro Leu Thr Met Ala Tyr 
305                 310                 315                 320 


Val Ser Ser Gly Ser Tyr Ser Tyr Met Thr Ser Ser Ala Ser Glu Phe 
                325                 330                 335     


Leu Leu Ser Leu Thr Leu Pro Gly Ala Pro Gly Ala Gln Ile Val His 
            340                 345                 350         


Ser Gln Val Glu Glu Gln Gln Leu Leu Ala Ala Gly Ser Ser Val Val 
        355                 360                 365             


Ser Cys Leu Leu Glu Gly Pro Val Gln Leu Gly Pro Gly Ser Val Leu 
    370                 375                 380                 


Gln His Cys His Leu Gln Gly Pro Ile His Ile Gly Ala Gly Cys Leu 
385                 390                 395                 400 


Val Thr Gly Leu Asp Thr Ala His Ser Lys Ala Leu His Gly Arg Glu 
                405                 410                 415     


Leu Arg Asp Leu Val Leu Gln Gly His His Thr Arg Leu His Gly Ser 
            420                 425                 430         


Pro Gly His Ala Phe Thr Leu Val Gly Arg Leu Asp Ser Trp Glu Arg 
        435                 440                 445             


Gln Gly Ala Gly Thr Tyr Leu Asn Val Pro Trp Ser Glu Phe Phe Lys 
    450                 455                 460                 


Arg Thr Gly Val Arg Ala Trp Asp Leu Trp Asp Pro Glu Thr Leu Pro 
465                 470                 475                 480 


Ala Glu Tyr Cys Leu Pro Ser Ala Arg Leu Phe Pro Val Leu His Pro 
                485                 490                 495     


Ser Arg Glu Leu Gly Pro Gln Asp Leu Leu Trp Met Leu Asp His Gln 
            500                 505                 510         


Glu Asp Gly Gly Glu Ala Leu Arg Ala Trp Arg Ala Ser Trp Arg Leu 
        515                 520                 525             


Ser Trp Glu Gln Leu Gln Pro Cys Leu Asp Arg Ala Ala Thr Leu Ala 
    530                 535                 540                 


Ser Arg Arg Asp Leu Phe Phe Arg Gln Ala Leu His Lys Ala Arg His 
545                 550                 555                 560 


Val Leu Glu Ala Arg Gln Asp Leu Ser Leu Arg Pro Leu Ile Trp Ala 
                565                 570                 575     


Ala Val Arg Glu Gly Cys Pro Gly Pro Leu Leu Ala Thr Leu Asp Gln 
            580                 585                 590         


Val Ala Ala Gly Ala Gly Asp Pro Gly Val Ala Ala Arg Ala Leu Ala 
        595                 600                 605             


Cys Val Ala Asp Val Leu Gly Cys Met Ala Glu Gly Arg Gly Gly Leu 
    610                 615                 620                 


Arg Ser Gly Pro Ala Ala Asn Pro Glu Trp Met Arg Pro Phe Ser Tyr 
625                 630                 635                 640 


Leu Glu Cys Gly Asp Leu Ala Ala Gly Val Glu Ala Leu Ala Gln Glu 
                645                 650                 655     


Arg Asp Lys Trp Leu Ser Arg Pro Ala Leu Leu Val Arg Ala Ala Arg 
            660                 665                 670         


His Tyr Glu Gly Ala Gly Gln Ile Leu Ile Arg Gln Ala Val Met Ser 
        675                 680                 685             


Ala Gln His Phe Val Ser Thr Glu Gln Val Glu Leu Pro Gly Pro Gly 
    690                 695                 700                 


Gln Trp Val Val Ala Glu Cys Pro Ala Arg Val Asp Phe Ser Gly Gly 
705                 710                 715                 720 


Trp Ser Asp Thr Pro Pro Leu Ala Tyr Glu Leu Gly Gly Ala Val Leu 
                725                 730                 735     


Gly Leu Ala Val Arg Val Asp Gly Arg Arg Pro Ile Gly Ala Arg Ala 
            740                 745                 750         


Arg Arg Ile Pro Glu Pro Glu Leu Trp Leu Ala Val Gly Pro Arg Gln 
        755                 760                 765             


Asp Glu Met Thr Val Lys Ile Val Cys Arg Cys Leu Ala Asp Leu Arg 
    770                 775                 780                 


Asp Tyr Cys Gln Pro His Ala Pro Gly Ala Leu Leu Lys Ala Ala Phe 
785                 790                 795                 800 


Ile Cys Ala Gly Ile Val His Val His Ser Glu Leu Gln Leu Ser Glu 
                805                 810                 815     


Gln Leu Leu Arg Thr Phe Gly Gly Gly Phe Glu Leu His Thr Trp Ser 
            820                 825                 830         


Glu Leu Pro His Gly Ser Gly Leu Gly Thr Ser Ser Ile Leu Ala Gly 
        835                 840                 845             


Thr Ala Leu Ala Ala Leu Gln Arg Ala Ala Gly Arg Val Val Gly Thr 
    850                 855                 860                 


Glu Ala Leu Ile His Ala Val Leu His Leu Glu Gln Val Leu Thr Thr 
865                 870                 875                 880 


Gly Gly Gly Trp Gln Asp Gln Val Gly Gly Leu Met Pro Gly Ile Lys 
                885                 890                 895     


Val Gly Arg Ser Arg Ala Gln Leu Pro Leu Lys Val Glu Val Glu Glu 
            900                 905                 910         


Val Thr Val Pro Glu Gly Phe Val Gln Lys Leu Asn Asp His Leu Leu 
        915                 920                 925             


Leu Val Tyr Thr Gly Lys Thr Arg Leu Ala Arg Asn Leu Leu Gln Asp 
    930                 935                 940                 


Val Leu Arg Ser Trp Tyr Ala Arg Leu Pro Ala Val Val Gln Asn Ala 
945                 950                 955                 960 


His Ser Leu Val Arg Gln Thr Glu Glu Cys Ala Glu Gly Phe Arg Gln 
                965                 970                 975     


Gly Ser Leu Pro Leu Leu Gly Gln Cys Leu Thr Ser Tyr Trp Glu Gln 
            980                 985                 990         


Lys Lys Leu Met Ala Pro Gly Cys  Glu Pro Leu Thr Val  Arg Arg Met 
        995                 1000                 1005             


Met Asp  Val Leu Ala Pro His  Val His Gly Gln Ser  Leu Ala Gly 
    1010                 1015                 1020             


Ala Gly  Gly Gly Gly Phe Leu  Tyr Leu Leu Thr Lys  Glu Pro Gln 
    1025                 1030                 1035             


Gln Lys  Glu Ala Leu Glu Ala  Val Leu Ala Lys Thr  Glu Gly Leu 
    1040                 1045                 1050             


Gly Asn  Tyr Ser Ile His Leu  Val Glu Val Asp Thr  Gln Gly Leu 
    1055                 1060                 1065             


Ser Leu  Lys Leu Leu Gly Thr  Glu Ala Ser Thr Cys  Cys Pro Phe 
    1070                 1075                 1080             


Pro 
    


<210> 5114
<211> 712
<212> PRT
<213> Homo sapiens

<400> 5114
Met Gln Pro Gly Ser Ala Pro Pro Pro Gly Arg Met Asp Pro Ser Ala 
1               5                   10                  15      


Pro Gln Pro Arg Ala Glu Thr Ser Gly Lys Asp Ile Trp His Pro Gly 
            20                  25                  30          


Glu Arg Cys Leu Ala Pro Ser Pro Asp Asn Gly Lys Leu Cys Glu Ala 
        35                  40                  45              


Ser Ile Lys Ser Ile Thr Val Asp Glu Asn Gly Lys Ser Phe Ala Val 
    50                  55                  60                  


Val Leu Tyr Ala Asp Phe Gln Glu Arg Lys Ile Pro Leu Lys Gln Leu 
65                  70                  75                  80  


Gln Glu Val Lys Phe Val Lys Asp Cys Pro Arg Asn Leu Ile Phe Asp 
                85                  90                  95      


Asp Glu Asp Leu Glu Lys Pro Tyr Phe Pro Asn Arg Lys Phe Pro Ser 
            100                 105                 110         


Ser Ser Val Ala Phe Lys Leu Ser Asp Asn Gly Asp Ser Ile Pro Tyr 
        115                 120                 125             


Thr Ile Asn Arg Tyr Leu Arg Asp Tyr Gln Arg Glu Gly Thr Arg Phe 
    130                 135                 140                 


Leu Tyr Gly His Tyr Ile His Gly Gly Gly Cys Ile Leu Gly Asp Asp 
145                 150                 155                 160 


Met Gly Leu Gly Lys Thr Val Gln Val Ile Ser Phe Leu Ala Ala Val 
                165                 170                 175     


Leu His Lys Lys Gly Thr Arg Glu Asp Ile Glu Asn Asn Met Pro Glu 
            180                 185                 190         


Phe Leu Leu Arg Ser Met Lys Lys Glu Pro Leu Ser Ser Thr Ala Lys 
        195                 200                 205             


Lys Met Phe Leu Ile Val Ala Pro Leu Ser Val Leu Tyr Asn Trp Lys 
    210                 215                 220                 


Asp Glu Leu Asp Thr Trp Gly Tyr Phe Arg Val Thr Val Leu His Gly 
225                 230                 235                 240 


Asn Arg Lys Asp Asn Glu Leu Ile Arg Val Lys Gln Arg Lys Cys Glu 
                245                 250                 255     


Ile Ala Leu Thr Thr Tyr Glu Thr Leu Arg Leu Cys Leu Asp Glu Leu 
            260                 265                 270         


Asn Ser Leu Glu Trp Ser Ala Val Ile Val Asp Glu Ala His Arg Ile 
        275                 280                 285             


Lys Asn Pro Lys Ala Arg Val Thr Glu Val Met Lys Ala Leu Lys Cys 
    290                 295                 300                 


Asn Val Arg Ile Gly Leu Thr Gly Thr Ile Leu Gln Asn Asn Met Lys 
305                 310                 315                 320 


Glu Leu Trp Cys Val Met Asp Trp Ala Val Pro Gly Leu Leu Gly Ser 
                325                 330                 335     


Gly Thr Tyr Phe Lys Lys Gln Phe Ser Asp Pro Val Glu His Gly Gln 
            340                 345                 350         


Arg His Thr Ala Thr Lys Arg Glu Leu Ala Thr Gly Arg Lys Ala Met 
        355                 360                 365             


Gln Arg Leu Ala Lys Lys Met Ser Gly Trp Phe Leu Arg Arg Thr Lys 
    370                 375                 380                 


Thr Leu Ile Lys Asp Gln Leu Pro Lys Lys Glu Asp Arg Met Val Tyr 
385                 390                 395                 400 


Cys Ser Leu Thr Asp Phe Gln Lys Ala Val Tyr Gln Thr Val Leu Glu 
                405                 410                 415     


Thr Glu Asp Val Thr Leu Ile Leu Gln Ser Ser Glu Pro Cys Thr Cys 
            420                 425                 430         


Arg Ser Gly Gln Lys Arg Arg Asn Cys Cys Tyr Lys Thr Asn Ser His 
        435                 440                 445             


Gly Glu Thr Val Lys Thr Leu Tyr Leu Ser Tyr Leu Thr Val Leu Gln 
    450                 455                 460                 


Lys Val Ala Asn His Val Ala Leu Leu Gln Ala Ala Ser Thr Ser Lys 
465                 470                 475                 480 


Gln Gln Glu Thr Leu Ile Lys Arg Ile Cys Asp Gln Val Phe Ser Arg 
                485                 490                 495     


Phe Pro Asp Phe Val Gln Lys Ser Lys Asp Ala Ala Phe Glu Thr Leu 
            500                 505                 510         


Ser Asp Pro Lys Tyr Ser Gly Lys Met Lys Val Leu Gln Gln Leu Leu 
        515                 520                 525             


Asn His Cys Arg Lys Asn Arg Asp Lys Val Leu Leu Phe Ser Phe Ser 
    530                 535                 540                 


Thr Lys Leu Leu Asp Val Leu Gln Gln Tyr Cys Met Ala Ser Gly Leu 
545                 550                 555                 560 


Asp Tyr Arg Arg Leu Asp Gly Ser Thr Lys Ser Glu Glu Arg Leu Lys 
                565                 570                 575     


Ile Val Lys Glu Phe Asn Ser Thr Gln Asp Val Asn Ile Cys Leu Val 
            580                 585                 590         


Ser Thr Met Ala Gly Gly Leu Gly Leu Asn Phe Val Gly Ala Asn Val 
        595                 600                 605             


Val Val Leu Phe Asp Pro Thr Trp Asn Pro Ala Asn Asp Leu Gln Ala 
    610                 615                 620                 


Ile Asp Arg Ala Tyr Arg Ile Gly Gln Cys Arg Asp Val Lys Val Leu 
625                 630                 635                 640 


Arg Leu Ile Ser Leu Gly Thr Val Glu Glu Ile Met Tyr Leu Arg Gln 
                645                 650                 655     


Ile Tyr Lys Gln Gln Leu His Cys Val Val Val Gly Ser Glu Asn Ala 
            660                 665                 670         


Lys Arg Tyr Phe Glu Ala Val Gln Gly Ser Lys Glu His Gln Gly Glu 
        675                 680                 685             


Leu Phe Gly Ile His Asn Leu Phe Lys Phe Arg Ser Gln Gly Ser Cys 
    690                 695                 700                 


Leu Thr Lys Asp Ile Leu Glu Val 
705                 710         


<210> 5115
<211> 403
<212> PRT
<213> Homo sapiens

<400> 5115
Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Thr Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Thr Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Thr Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Thr Ser Asp Gly Thr Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Thr Glu Pro Lys Ala Val Arg Thr Thr Thr Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Thr Ser Tyr Leu Thr Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Thr Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Thr His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Thr Ile Val Ser Ser Thr Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Thr Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Thr Thr Asp Met Thr Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Thr Glu Pro Ser Ser Thr Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Thr Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Thr Thr Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Thr Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Thr Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Thr Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Thr Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Thr Ser Met Leu Leu Asp Gln Val His Pro Leu 
            340                 345                 350         


Leu Met Lys Ile Leu Leu Glu His Gln His Arg Ser Glu Pro Phe Leu 
        355                 360                 365             


Gly Ile Gly Leu Lys Thr Thr Leu Lys Ile Thr Ser Ser Leu Gln Leu 
    370                 375                 380                 


Arg Ile His Phe Gly Asp Met Thr Gln Lys Leu Ile Pro Glu Leu Tyr 
385                 390                 395                 400 


Ser Cys Tyr 
            


<210> 5116
<211> 1220
<212> PRT
<213> Homo sapiens

<400> 5116
Met Gly Lys Lys Gln Lys Asn Lys Ser Glu Asp Ser Thr Lys Asp Asp 
1               5                   10                  15      


Ile Asp Leu Asp Ala Leu Ala Ala Glu Ile Glu Gly Ala Gly Ala Ala 
            20                  25                  30          


Lys Glu Gln Glu Pro Gln Lys Ser Lys Gly Lys Lys Lys Lys Glu Lys 
        35                  40                  45              


Lys Lys Gln Asp Phe Asp Glu Asp Asp Ile Leu Lys Glu Leu Glu Glu 
    50                  55                  60                  


Leu Ser Leu Glu Ala Gln Gly Ile Lys Ala Asp Arg Glu Thr Val Ala 
65                  70                  75                  80  


Val Lys Pro Thr Glu Asn Asn Glu Glu Glu Phe Thr Ser Lys Asp Lys 
                85                  90                  95      


Lys Lys Lys Gly Gln Lys Gly Lys Lys Gln Ser Phe Asp Asp Asn Asp 
            100                 105                 110         


Ser Glu Glu Leu Glu Asp Lys Asp Ser Lys Ser Lys Lys Thr Ala Lys 
        115                 120                 125             


Pro Lys Val Glu Met Tyr Ser Gly Ser Asp Asp Asp Asp Asp Phe Asn 
    130                 135                 140                 


Lys Leu Pro Lys Lys Ala Lys Gly Lys Ala Gln Lys Ser Asn Lys Lys 
145                 150                 155                 160 


Trp Asp Gly Ser Glu Glu Asp Glu Asp Asn Ser Lys Lys Ile Lys Glu 
                165                 170                 175     


Arg Ser Arg Ile Asn Ser Ser Gly Glu Ser Gly Asp Glu Ser Asp Glu 
            180                 185                 190         


Phe Leu Gln Ser Arg Lys Gly Gln Lys Lys Asn Gln Lys Asn Lys Pro 
        195                 200                 205             


Gly Pro Asn Ile Glu Ser Gly Asn Glu Asp Asp Asp Ala Ser Phe Lys 
    210                 215                 220                 


Ile Lys Thr Val Ala Gln Lys Lys Ala Glu Lys Lys Glu Arg Glu Arg 
225                 230                 235                 240 


Lys Lys Arg Asp Glu Glu Lys Ala Lys Leu Arg Lys Leu Lys Glu Lys 
                245                 250                 255     


Glu Glu Leu Glu Thr Gly Lys Lys Asp Gln Ser Lys Gln Lys Glu Ser 
            260                 265                 270         


Gln Arg Lys Phe Glu Glu Glu Thr Val Lys Ser Lys Val Thr Val Asp 
        275                 280                 285             


Thr Gly Val Ile Pro Ala Ser Glu Glu Lys Ala Glu Thr Pro Thr Ala 
    290                 295                 300                 


Ala Glu Asp Asp Asn Glu Gly Asp Lys Lys Lys Lys Asp Lys Lys Lys 
305                 310                 315                 320 


Lys Lys Gly Glu Lys Glu Glu Lys Glu Lys Glu Lys Lys Lys Gly Pro 
                325                 330                 335     


Ser Lys Ala Thr Val Lys Ala Met Gln Glu Ala Leu Ala Lys Leu Lys 
            340                 345                 350         


Glu Glu Glu Glu Arg Gln Lys Arg Glu Glu Glu Glu Arg Ile Lys Arg 
        355                 360                 365             


Leu Glu Glu Leu Glu Ala Lys Arg Lys Glu Glu Glu Arg Leu Glu Gln 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Lys Gln Lys Glu Lys Glu Arg Lys Glu Arg 
385                 390                 395                 400 


Leu Lys Lys Glu Gly Lys Leu Leu Thr Lys Ser Gln Arg Glu Ala Arg 
                405                 410                 415     


Ala Arg Ala Glu Ala Thr Leu Lys Leu Leu Gln Ala Gln Gly Val Glu 
            420                 425                 430         


Val Pro Ser Lys Asp Ser Leu Pro Lys Lys Arg Pro Ile Tyr Glu Asp 
        435                 440                 445             


Lys Lys Arg Lys Lys Ile Pro Gln Gln Leu Glu Ser Lys Glu Val Ser 
    450                 455                 460                 


Glu Ser Met Glu Leu Cys Ala Ala Val Glu Val Met Glu Gln Gly Val 
465                 470                 475                 480 


Pro Glu Lys Glu Glu Thr Pro Pro Pro Val Glu Pro Glu Glu Glu Glu 
                485                 490                 495     


Asp Thr Glu Asp Ala Gly Leu Asp Asp Trp Glu Ala Met Ala Ser Asp 
            500                 505                 510         


Glu Glu Thr Glu Lys Val Glu Gly Asn Lys Val His Ile Glu Val Lys 
        515                 520                 525             


Glu Asn Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    530                 535                 540                 


Glu Glu Ser Glu Glu Glu Glu Glu Glu Glu Gly Glu Ser Glu Gly Ser 
545                 550                 555                 560 


Glu Gly Asp Glu Glu Asp Glu Lys Val Ser Asp Glu Lys Asp Ser Gly 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Pro Ser Lys Glu Met Ser Ser Asp Ser Glu 
            580                 585                 590         


Tyr Asp Ser Asp Asp Asp Arg Thr Lys Glu Glu Arg Ala Tyr Asp Lys 
        595                 600                 605             


Ala Lys Arg Arg Ile Glu Lys Arg Arg Leu Glu His Ser Lys Asn Val 
    610                 615                 620                 


Asn Thr Glu Lys Leu Arg Ala Pro Ile Ile Cys Val Leu Gly His Val 
625                 630                 635                 640 


Asp Thr Gly Lys Thr Lys Ile Leu Asp Lys Leu Arg His Thr His Val 
                645                 650                 655     


Gln Asp Gly Glu Ala Gly Gly Ile Thr Gln Gln Ile Gly Ala Thr Asn 
            660                 665                 670         


Val Pro Leu Glu Ala Ile Asn Glu Gln Thr Lys Met Ile Lys Asn Phe 
        675                 680                 685             


Asp Arg Glu Asn Val Arg Ile Pro Gly Met Leu Ile Ile Asp Thr Pro 
    690                 695                 700                 


Gly His Glu Ser Phe Ser Asn Leu Arg Asn Arg Gly Ser Ser Leu Cys 
705                 710                 715                 720 


Asp Ile Ala Ile Leu Val Val Asp Ile Met His Gly Leu Glu Pro Gln 
                725                 730                 735     


Thr Ile Glu Ser Ile Asn Leu Leu Lys Ser Lys Lys Cys Pro Phe Ile 
            740                 745                 750         


Val Ala Leu Asn Lys Ile Asp Arg Leu Tyr Asp Trp Lys Lys Ser Pro 
        755                 760                 765             


Asp Ser Asp Val Ala Ala Thr Leu Lys Lys Gln Lys Lys Asn Thr Lys 
    770                 775                 780                 


Asp Glu Phe Glu Glu Arg Ala Lys Ala Ile Ile Val Glu Phe Ala Gln 
785                 790                 795                 800 


Gln Gly Leu Asn Ala Ala Leu Phe Tyr Glu Asn Lys Asp Pro Arg Thr 
                805                 810                 815     


Phe Val Ser Leu Val Pro Thr Ser Ala His Thr Gly Asp Gly Met Gly 
            820                 825                 830         


Ser Leu Ile Tyr Leu Leu Val Glu Leu Thr Gln Thr Met Leu Ser Lys 
        835                 840                 845             


Arg Leu Ala His Cys Glu Glu Leu Arg Ala Gln Val Met Glu Val Lys 
    850                 855                 860                 


Ala Leu Pro Gly Met Gly Thr Thr Ile Asp Val Ile Leu Ile Asn Gly 
865                 870                 875                 880 


Arg Leu Lys Glu Gly Asp Thr Ile Ile Val Pro Gly Val Glu Gly Pro 
                885                 890                 895     


Ile Val Thr Gln Ile Arg Gly Leu Leu Leu Pro Pro Pro Met Lys Glu 
            900                 905                 910         


Leu Arg Val Lys Asn Gln Tyr Glu Lys His Lys Glu Val Glu Ala Ala 
        915                 920                 925             


Gln Gly Val Lys Ile Leu Gly Lys Asp Leu Glu Lys Thr Leu Ala Gly 
    930                 935                 940                 


Leu Pro Leu Leu Val Ala Tyr Lys Glu Asp Glu Ile Pro Val Leu Lys 
945                 950                 955                 960 


Asp Glu Leu Ile His Glu Leu Lys Gln Thr Leu Asn Ala Ile Lys Leu 
                965                 970                 975     


Glu Glu Lys Gly Val Tyr Val Gln Ala Ser Thr Leu Gly Ser Leu Glu 
            980                 985                 990         


Ala Leu Leu Glu Phe Leu Lys Thr  Ser Glu Val Pro Tyr  Ala Gly Ile 
        995                 1000                 1005             


Asn Ile  Gly Pro Val His Lys  Lys Asp Val Met Lys  Ala Ser Val 
    1010                 1015                 1020             


Met Leu  Glu His Asp Pro Gln  Tyr Ala Val Ile Leu  Ala Phe Asp 
    1025                 1030                 1035             


Val Arg  Ile Glu Arg Asp Ala  Gln Glu Met Ala Asp  Ser Leu Gly 
    1040                 1045                 1050             


Val Arg  Ile Phe Ser Ala Glu  Ile Ile Tyr His Leu  Phe Asp Ala 
    1055                 1060                 1065             


Phe Thr  Lys Tyr Arg Gln Asp  Tyr Lys Lys Gln Lys  Gln Glu Glu 
    1070                 1075                 1080             


Phe Lys  His Ile Ala Val Phe  Pro Cys Lys Ile Lys  Ile Leu Pro 
    1085                 1090                 1095             


Gln Tyr  Ile Phe Asn Ser Arg  Asp Pro Ile Val Met  Gly Val Thr 
    1100                 1105                 1110             


Val Glu  Ala Gly Gln Val Lys  Gln Gly Thr Pro Met  Cys Val Pro 
    1115                 1120                 1125             


Ser Lys  Asn Phe Val Asp Ile  Gly Ile Val Thr Ser  Ile Glu Ile 
    1130                 1135                 1140             


Asn His  Lys Gln Val Asp Val  Ala Lys Lys Gly Gln  Glu Val Cys 
    1145                 1150                 1155             


Val Lys  Ile Glu Pro Ile Pro  Gly Glu Ser Pro Lys  Met Phe Gly 
    1160                 1165                 1170             


Arg His  Phe Glu Ala Thr Asp  Ile Leu Val Ser Lys  Ile Ser Arg 
    1175                 1180                 1185             


Gln Ser  Ile Asp Ala Leu Lys  Asp Trp Phe Arg Asp  Glu Met Gln 
    1190                 1195                 1200             


Lys Ser  Asp Trp Gln Leu Ile  Val Glu Leu Lys Lys  Val Phe Glu 
    1205                 1210                 1215             


Ile Ile  
    1220 


<210> 5117
<211> 45
<212> PRT
<213> Homo sapiens

<400> 5117
Met Ser Asp Lys Pro Asp Leu Ser Glu Val Glu Lys Phe Asp Arg Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Asn Thr Glu Glu Lys Asn Thr Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Gln Gln Glu Lys Glu Cys Val Gln Thr Ser 
        35                  40                  45  


<210> 5118
<211> 510
<212> PRT
<213> Homo sapiens

<400> 5118
Met Pro Gly Gly Gly Ala Ser Ala Ala Ser Gly Arg Leu Leu Thr Ala 
1               5                   10                  15      


Ala Glu Gln Arg Gly Ser Arg Glu Ala Ala Gly Ser Ala Ser Arg Ser 
            20                  25                  30          


Gly Phe Gly Gly Ser Gly Gly Gly Arg Gly Gly Ala Ser Gly Pro Gly 
        35                  40                  45              


Ser Gly Ser Gly Gly Pro Gly Gly Pro Ala Gly Arg Met Ser Leu Thr 
    50                  55                  60                  


Pro Lys Glu Leu Ser Ser Leu Leu Ser Ile Ile Ser Glu Glu Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Thr Phe Glu Gly Leu Ser Thr Ala Phe His His Tyr Phe 
                85                  90                  95      


Ser Lys Ala Asp His Phe Arg Leu Gly Ser Val Leu Val Met Leu Leu 
            100                 105                 110         


Gln Gln Pro Asp Leu Leu Pro Ser Ala Ala Gln Arg Leu Thr Ala Leu 
        115                 120                 125             


Tyr Leu Leu Trp Glu Met Tyr Arg Thr Glu Pro Leu Ala Ala Asn Pro 
    130                 135                 140                 


Phe Ala Ala Ser Phe Ala His Leu Leu Asn Pro Ala Pro Pro Ala Arg 
145                 150                 155                 160 


Gly Gly Gln Glu Pro Asp Arg Pro Pro Leu Ser Gly Phe Leu Pro Pro 
                165                 170                 175     


Ile Thr Pro Pro Glu Lys Phe Phe Leu Ser Gln Leu Met Leu Ala Pro 
            180                 185                 190         


Pro Arg Glu Leu Phe Lys Lys Thr Pro Arg Gln Ile Ala Leu Met Asp 
        195                 200                 205             


Val Gly Asn Met Gly Gln Ser Val Asp Ile Ser Gly Leu Gln Leu Ala 
    210                 215                 220                 


Leu Ala Glu Arg Gln Ser Glu Leu Pro Thr Gln Ser Lys Ala Ser Phe 
225                 230                 235                 240 


Pro Ser Ile Leu Ser Asp Pro Asp Pro Asp Ser Ser Asn Ser Gly Phe 
                245                 250                 255     


Asp Ser Ser Val Ala Ser Gln Ile Thr Glu Ala Leu Val Ser Gly Pro 
            260                 265                 270         


Lys Pro Pro Ile Glu Ser His Phe Arg Pro Glu Phe Ile Arg Pro Pro 
        275                 280                 285             


Pro Pro Leu His Ile Cys Glu Asp Glu Leu Ala Trp Leu Asn Pro Thr 
    290                 295                 300                 


Glu Pro Asp His Ala Ile Gln Trp Asp Lys Ser Met Cys Val Lys Asn 
305                 310                 315                 320 


Ser Thr Gly Val Glu Ile Lys Arg Ile Met Ala Lys Ala Phe Lys Ser 
                325                 330                 335     


Pro Leu Ser Ser Pro Gln Gln Thr Gln Leu Leu Gly Glu Leu Glu Lys 
            340                 345                 350         


Asp Pro Lys Leu Val Tyr His Ile Gly Leu Thr Pro Ala Lys Leu Pro 
        355                 360                 365             


Asp Leu Val Glu Asn Asn Pro Leu Val Ala Ile Glu Met Leu Leu Lys 
    370                 375                 380                 


Leu Met Gln Ser Ser Gln Ile Thr Glu Tyr Phe Ser Val Leu Val Asn 
385                 390                 395                 400 


Met Asp Met Ser Leu His Ser Met Glu Val Val Asn Arg Leu Thr Thr 
                405                 410                 415     


Ala Val Asp Leu Pro Pro Glu Phe Ile His Leu Tyr Ile Ser Asn Cys 
            420                 425                 430         


Ile Ser Thr Cys Glu Gln Ile Lys Asp Lys Tyr Met Gln Asn Arg Leu 
        435                 440                 445             


Val Arg Leu Val Cys Val Phe Leu Gln Ser Leu Ile Arg Asn Lys Ile 
    450                 455                 460                 


Ile Asn Val Gln Asp Leu Phe Ile Glu Val Gln Ala Phe Cys Ile Glu 
465                 470                 475                 480 


Phe Ser Arg Ile Arg Glu Ala Ala Gly Leu Phe Arg Leu Leu Lys Thr 
                485                 490                 495     


Leu Asp Thr Gly Glu Thr Pro Ser Glu Thr Lys Met Ser Lys 
            500                 505                 510 


<210> 5119
<211> 727
<212> PRT
<213> Homo sapiens

<400> 5119
Met Ser Gly Arg Lys Arg Ser Phe Thr Phe Gly Ala Tyr Gly Gly Val 
1               5                   10                  15      


Asp Lys Ser Phe Thr Ser Arg Arg Ser Val Trp Arg Ser Asp Gly Gln 
            20                  25                  30          


Asn Gln His Phe Pro Gln Ala Leu Asp Leu Ser Arg Val Asn Leu Val 
        35                  40                  45              


Pro Ser Tyr Thr Pro Ser Leu Tyr Pro Lys Asn Thr Asp Leu Phe Glu 
    50                  55                  60                  


Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
65                  70                  75                  80  


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
                85                  90                  95      


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
            100                 105                 110         


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
        115                 120                 125             


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
    130                 135                 140                 


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
145                 150                 155                 160 


Lys Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu 
                165                 170                 175     


Val Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg 
            180                 185                 190         


Leu Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile 
        195                 200                 205             


Ser Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val 
    210                 215                 220                 


Cys Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys 
225                 230                 235                 240 


Ala Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn 
                245                 250                 255     


Phe Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu 
            260                 265                 270         


Glu Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu 
        275                 280                 285             


Glu Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg 
    290                 295                 300                 


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr 
305                 310                 315                 320 


Cys Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu 
                325                 330                 335     


Pro Tyr Thr Glu Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
            340                 345                 350         


Gly Asn Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe 
        355                 360                 365             


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val 
    370                 375                 380                 


Gln Ala Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val 
385                 390                 395                 400 


Thr Ala Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro 
                405                 410                 415     


Ala Val Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys 
            420                 425                 430         


Leu Ile Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys 
        435                 440                 445             


Leu Glu Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu 
    450                 455                 460                 


Leu His Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp 
465                 470                 475                 480 


Lys Met Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys 
                485                 490                 495     


Arg Val Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser 
            500                 505                 510         


Asn Lys Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala 
        515                 520                 525             


Pro Asn Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Ile Val 
    530                 535                 540                 


Pro Gly Lys Ser Pro Thr Arg Lys Lys Ser Gly Pro Phe Gly Ser Arg 
545                 550                 555                 560 


Arg Ser Ser Ala Ile Gly Ile Glu Asn Ile Gln Glu Val Gln Glu Lys 
                565                 570                 575     


Arg Glu Ser Pro Pro Ala Gly Gln Lys Thr Pro Asp Ser Gly His Val 
            580                 585                 590         


Ser Gln Glu Pro Lys Ser Glu Asn Ser Ser Thr Gln Ser Ser Pro Glu 
        595                 600                 605             


Met Pro Thr Thr Lys Asn Arg Ala Glu Thr Ala Ala Gln Arg Ala Glu 
    610                 615                 620                 


Ala Leu Lys Asp Phe Ser Arg Ser Ser Ser Ser Ala Ser Ser Phe Ala 
625                 630                 635                 640 


Ser Val Val Glu Glu Thr Glu Gly Val Asp Gly Glu Asp Thr Gly Leu 
                645                 650                 655     


Glu Ser Val Ser Ser Ser Gly Thr Pro His Lys Arg Asp Ser Phe Ile 
            660                 665                 670         


Tyr Ser Thr Trp Leu Glu Asp Ser Val Ser Thr Thr Ser Gly Gly Ser 
        675                 680                 685             


Ser Pro Gly Pro Ser Arg Ser Pro His Pro Asp Ala Gly Lys Leu Gly 
    690                 695                 700                 


Asp Pro Ala Cys Pro Glu Ile Lys Ile Gln Leu Glu Ala Ser Glu Gln 
705                 710                 715                 720 


His Met Pro Gln Leu Gly Cys 
                725         


<210> 5120
<211> 290
<212> PRT
<213> Homo sapiens

<400> 5120
Met Val Leu Leu His Val Lys Arg Gly Asp Glu Ser Gln Phe Leu Leu 
1               5                   10                  15      


Gln Ala Pro Gly Ser Thr Glu Leu Glu Glu Leu Thr Val Gln Val Ala 
            20                  25                  30          


Arg Val Tyr Asn Gly Arg Leu Lys Val Gln Arg Leu Cys Ser Glu Met 
        35                  40                  45              


Glu Glu Leu Ala Glu His Gly Ile Phe Leu Pro Pro Asn Met Gln Gly 
    50                  55                  60                  


Leu Thr Asp Asp Gln Ile Glu Glu Leu Lys Leu Lys Asp Glu Trp Gly 
65                  70                  75                  80  


Glu Lys Cys Val Pro Ser Gly Gly Ala Val Phe Lys Lys Asp Asp Ile 
                85                  90                  95      


Gly Arg Arg Asn Gly Gln Ala Pro Asn Glu Lys Met Lys Gln Val Leu 
            100                 105                 110         


Lys Lys Thr Ile Glu Glu Ala Lys Ala Ile Ile Ser Lys Lys Gln Val 
        115                 120                 125             


Glu Ala Gly Val Cys Val Thr Met Glu Met Val Lys Asp Ala Leu Asp 
    130                 135                 140                 


Gln Leu Arg Gly Ala Val Met Ile Val Tyr Pro Met Gly Leu Pro Pro 
145                 150                 155                 160 


Tyr Asp Pro Ile Arg Met Glu Phe Glu Asn Lys Glu Asp Leu Ser Gly 
                165                 170                 175     


Thr Gln Ala Gly Leu Asn Val Ile Lys Glu Ala Glu Ala Gln Leu Trp 
            180                 185                 190         


Trp Ala Ala Lys Glu Leu Arg Arg Thr Lys Lys Leu Ser Asp Tyr Val 
        195                 200                 205             


Gly Lys Asn Glu Lys Thr Lys Ile Ile Ala Lys Ile Gln Gln Arg Gly 
    210                 215                 220                 


Gln Gly Ala Pro Ala Arg Glu Pro Ile Ile Ser Ser Glu Glu Gln Lys 
225                 230                 235                 240 


Gln Leu Met Leu Tyr Tyr His Arg Arg Gln Glu Glu Leu Lys Arg Leu 
                245                 250                 255     


Glu Glu Asn Asp Asp Asp Ala Tyr Leu Asn Ser Pro Trp Ala Asp Asn 
            260                 265                 270         


Thr Ala Leu Lys Arg His Phe His Gly Val Lys Asp Ile Lys Trp Arg 
        275                 280                 285             


Pro Arg 
    290 


<210> 5121
<211> 188
<212> PRT
<213> Homo sapiens

<400> 5121
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
            20                  25                  30          


Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
    130                 135                 140                 


Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Cys Arg 
            180                 185             


<210> 5122
<211> 677
<212> PRT
<213> Homo sapiens

<400> 5122
Met Asp Asp Pro Asp Cys Asp Ser Thr Trp Glu Glu Asp Glu Glu Asp 
1               5                   10                  15      


Ala Glu Asp Ala Glu Asp Glu Asp Cys Glu Asp Gly Glu Ala Ala Gly 
            20                  25                  30          


Ala Arg Asp Ala Asp Ala Gly Asp Glu Asp Glu Glu Ser Glu Glu Pro 
        35                  40                  45              


Arg Ala Ala Arg Pro Ser Ser Phe Gln Ser Arg Met Thr Gly Ser Arg 
    50                  55                  60                  


Asn Trp Arg Ala Thr Arg Asp Met Cys Arg Tyr Arg His Asn Tyr Pro 
65                  70                  75                  80  


Asp Leu Val Glu Arg Asp Cys Asn Gly Asp Thr Pro Asn Leu Ser Phe 
                85                  90                  95      


Tyr Arg Asn Glu Ile Arg Phe Leu Pro Asn Gly Cys Phe Ile Glu Asp 
            100                 105                 110         


Ile Leu Gln Asn Trp Thr Asp Asn Tyr Asp Leu Leu Glu Asp Asn His 
        115                 120                 125             


Ser Tyr Ile Gln Trp Leu Phe Pro Leu Arg Glu Pro Gly Val Asn Trp 
    130                 135                 140                 


His Ala Lys Pro Leu Thr Leu Arg Glu Val Glu Val Phe Lys Ser Ser 
145                 150                 155                 160 


Gln Glu Ile Gln Glu Arg Leu Val Arg Ala Tyr Glu Leu Met Leu Gly 
                165                 170                 175     


Phe Tyr Gly Ile Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg 
            180                 185                 190         


Ala Gln Asn Tyr Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His 
        195                 200                 205             


Asn Asn Leu Arg Ile Thr Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly 
    210                 215                 220                 


Leu Glu His Phe Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr 
225                 230                 235                 240 


Leu Val Arg Arg Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr 
                245                 250                 255     


Phe Met Phe Ala Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His 
            260                 265                 270         


Phe Ala Trp Glu His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro 
        275                 280                 285             


Gln Asp Lys Leu Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu 
    290                 295                 300                 


Glu Gly Ser Arg Lys Val Glu Glu Glu Gly Ser Pro Gly Asp Pro Asp 
305                 310                 315                 320 


His Glu Ala Ser Thr Gln Gly Arg Thr Cys Gly Pro Glu His Ser Lys 
                325                 330                 335     


Gly Gly Gly Arg Val Asp Glu Gly Pro Gln Pro Arg Ser Val Glu Pro 
            340                 345                 350         


Gln Asp Ala Gly Pro Leu Glu Arg Ser Gln Gly Asp Glu Ala Gly Gly 
        355                 360                 365             


His Gly Glu Asp Arg Pro Glu Pro Leu Ser Pro Lys Glu Ser Lys Lys 
    370                 375                 380                 


Arg Lys Leu Glu Leu Ser Arg Arg Glu Gln Pro Pro Thr Glu Pro Gly 
385                 390                 395                 400 


Pro Gln Ser Ala Ser Glu Val Glu Lys Ile Ala Leu Asn Leu Glu Gly 
                405                 410                 415     


Cys Ala Leu Ser Gln Gly Ser Leu Arg Thr Gly Thr Gln Glu Val Gly 
            420                 425                 430         


Gly Gln Asp Pro Gly Glu Ala Val Gln Pro Cys Arg Gln Pro Leu Gly 
        435                 440                 445             


Ala Arg Val Ala Asp Lys Val Arg Lys Arg Arg Lys Val Asp Glu Gly 
    450                 455                 460                 


Ala Gly Asp Ser Ala Ala Val Ala Ser Gly Gly Ala Gln Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Gly Ser Pro Ala Pro Ser Gly His Pro Lys Ala Gly His Ser 
                485                 490                 495     


Glu Asn Gly Val Glu Glu Asp Thr Glu Gly Arg Thr Gly Pro Lys Glu 
            500                 505                 510         


Gly Thr Pro Gly Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly 
        515                 520                 525             


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
    530                 535                 540                 


Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu 
545                 550                 555                 560 


Thr Pro Gly Pro Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu 
                565                 570                 575     


Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp 
            580                 585                 590         


Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly 
        595                 600                 605             


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
    610                 615                 620                 


Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu 
625                 630                 635                 640 


Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Lys 
                645                 650                 655     


Ala Gly Glu Ala Ala Glu Leu Gln Asp Ala Glu Val Glu Ser Ser Ala 
            660                 665                 670         


Lys Ser Gly Lys Pro 
        675         


<210> 5123
<211> 244
<212> PRT
<213> Homo sapiens

<400> 5123
Met Gly Leu Glu Leu Phe Leu Asp Leu Val Ser Gln Pro Ser Arg Ala 
1               5                   10                  15      


Val Tyr Ile Phe Ala Lys Lys Asn Gly Ile Pro Leu Glu Leu Arg Thr 
            20                  25                  30          


Val Asp Leu Val Lys Gly Gln His Lys Ser Lys Glu Phe Leu Gln Ile 
        35                  40                  45              


Asn Ser Leu Gly Lys Leu Pro Thr Leu Lys Asp Gly Asp Phe Ile Leu 
    50                  55                  60                  


Thr Glu Ser Ser Ala Ile Leu Ile Tyr Leu Ser Cys Lys Tyr Gln Thr 
65                  70                  75                  80  


Pro Asp His Trp Tyr Pro Ser Asp Leu Gln Ala Arg Ala Arg Val His 
                85                  90                  95      


Glu Tyr Leu Gly Trp His Ala Asp Cys Ile Arg Gly Thr Phe Gly Ile 
            100                 105                 110         


Pro Leu Trp Val Gln Val Leu Gly Pro Leu Ile Gly Val Gln Val Pro 
        115                 120                 125             


Glu Glu Lys Val Glu Arg Asn Arg Thr Ala Met Asp Gln Ala Leu Gln 
    130                 135                 140                 


Trp Leu Glu Asp Lys Phe Leu Gly Asp Arg Pro Phe Leu Ala Gly Gln 
145                 150                 155                 160 


Gln Val Thr Leu Ala Asp Leu Met Ala Leu Glu Glu Leu Met Gln Pro 
                165                 170                 175     


Val Ala Leu Gly Tyr Glu Leu Phe Glu Gly Arg Pro Arg Leu Ala Ala 
            180                 185                 190         


Trp Arg Gly Arg Val Glu Ala Phe Leu Gly Ala Glu Leu Cys Gln Glu 
        195                 200                 205             


Ala His Ser Ile Ile Leu Ser Ile Leu Glu Gln Ala Ala Lys Lys Thr 
    210                 215                 220                 


Leu Pro Thr Pro Ser Pro Glu Ala Tyr Gln Ala Met Leu Leu Arg Ile 
225                 230                 235                 240 


Ala Arg Ile Pro 
                


<210> 5124
<211> 176
<212> PRT
<213> Homo sapiens

<400> 5124
Met Ala Ala Ser Thr Asp Met Ala Gly Leu Glu Glu Ser Phe Arg Lys 
1               5                   10                  15      


Phe Ala Ile His Gly Asp Pro Lys Ala Ser Gly Gln Glu Met Asn Gly 
            20                  25                  30          


Lys Asn Trp Ala Lys Leu Cys Lys Asp Cys Lys Val Ala Asp Gly Lys 
        35                  40                  45              


Ser Val Thr Gly Thr Asp Val Asp Ile Val Phe Ser Lys Val Lys Gly 
    50                  55                  60                  


Lys Ser Ala Arg Val Ile Asn Tyr Glu Glu Phe Lys Lys Ala Leu Glu 
65                  70                  75                  80  


Glu Leu Ala Thr Lys Arg Phe Lys Gly Lys Ser Lys Glu Glu Ala Phe 
                85                  90                  95      


Asp Ala Ile Cys Gln Leu Val Ala Gly Lys Glu Pro Ala Asn Val Gly 
            100                 105                 110         


Val Thr Lys Ala Lys Thr Gly Gly Ala Val Asp Arg Leu Thr Asp Thr 
        115                 120                 125             


Ser Arg Tyr Thr Gly Ser His Lys Glu Arg Phe Asp Glu Ser Gly Lys 
    130                 135                 140                 


Gly Lys Gly Ile Ala Gly Arg Gln Asp Ile Leu Asp Asp Ser Gly Tyr 
145                 150                 155                 160 


Val Ser Ala Tyr Lys Asn Ala Gly Thr Tyr Asp Ala Lys Val Lys Lys 
                165                 170                 175     


<210> 5125
<211> 309
<212> PRT
<213> Homo sapiens

<400> 5125
Met Ser Asp Leu Gly Ser Glu Glu Leu Glu Glu Glu Gly Glu Asn Asp 
1               5                   10                  15      


Ile Gly Glu Tyr Glu Gly Gly Arg Asn Glu Ala Gly Glu Arg His Gly 
            20                  25                  30          


Arg Gly Arg Ala Arg Leu Pro Asn Gly Asp Thr Tyr Glu Gly Ser Tyr 
        35                  40                  45              


Glu Phe Gly Lys Arg His Gly Gln Gly Ile Tyr Lys Phe Lys Asn Gly 
    50                  55                  60                  


Ala Arg Tyr Ile Gly Glu Tyr Val Arg Asn Lys Lys His Gly Gln Gly 
65                  70                  75                  80  


Thr Phe Ile Tyr Pro Asp Gly Ser Arg Tyr Glu Gly Glu Trp Ala Asn 
                85                  90                  95      


Asp Leu Arg His Gly His Gly Val Tyr Tyr Tyr Ile Asn Asn Asp Thr 
            100                 105                 110         


Tyr Thr Gly Glu Trp Phe Ala His Gln Arg His Gly Gln Gly Thr Tyr 
        115                 120                 125             


Leu Tyr Ala Glu Thr Gly Ser Lys Tyr Val Gly Thr Trp Val Asn Gly 
    130                 135                 140                 


Gln Gln Glu Gly Thr Ala Glu Leu Ile His Leu Asn His Arg Tyr Gln 
145                 150                 155                 160 


Gly Lys Phe Leu Asn Lys Asn Pro Val Gly Pro Gly Lys Tyr Val Phe 
                165                 170                 175     


Asp Val Gly Cys Glu Gln His Gly Glu Tyr Arg Leu Thr Asp Met Glu 
            180                 185                 190         


Arg Gly Glu Glu Glu Glu Glu Glu Glu Leu Val Thr Val Val Pro Lys 
        195                 200                 205             


Trp Lys Ala Thr Gln Ile Thr Glu Leu Ala Leu Trp Thr Pro Thr Leu 
    210                 215                 220                 


Pro Lys Lys Pro Thr Ser Thr Asp Gly Pro Gly Gln Asp Ala Pro Gly 
225                 230                 235                 240 


Ala Glu Ser Ala Gly Glu Pro Gly Glu Glu Ala Gln Ala Leu Leu Glu 
                245                 250                 255     


Gly Phe Glu Gly Glu Met Asp Met Arg Pro Gly Asp Glu Asp Ala Asp 
            260                 265                 270         


Val Leu Arg Glu Glu Ser Arg Glu Tyr Asp Gln Glu Glu Phe Arg Tyr 
        275                 280                 285             


Asp Met Asp Glu Gly Asn Ile Asn Ser Glu Glu Glu Glu Thr Arg Gln 
    290                 295                 300                 


Ser Asp Leu Gln Asp 
305                 


<210> 5126
<211> 1980
<212> PRT
<213> Homo sapiens

<400> 5126
Met Asn Pro Thr Asn Pro Phe Ser Gly Gln Gln Pro Ser Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ser Ser Asn Val Gly Thr Leu Pro Ser Lys Pro Pro Phe Arg 
            20                  25                  30          


Phe Gly Gln Pro Ser Leu Phe Gly Gln Asn Ser Thr Leu Ser Gly Lys 
        35                  40                  45              


Ser Ser Gly Phe Ser Gln Val Ser Ser Phe Pro Ala Ser Ser Gly Val 
    50                  55                  60                  


Ser His Ser Ser Ser Val Gln Thr Leu Gly Phe Thr Gln Thr Ser Ser 
65                  70                  75                  80  


Val Gly Pro Phe Ser Gly Leu Glu His Thr Ser Thr Phe Val Ala Thr 
                85                  90                  95      


Ser Gly Pro Ser Ser Ser Ser Val Leu Gly Asn Thr Gly Phe Ser Phe 
            100                 105                 110         


Lys Ser Pro Thr Ser Val Gly Ala Phe Pro Ser Thr Ser Ala Phe Gly 
        115                 120                 125             


Gln Glu Ala Gly Glu Ile Val Asn Ser Gly Phe Gly Lys Thr Glu Phe 
    130                 135                 140                 


Ser Phe Lys Pro Leu Glu Asn Ala Val Phe Lys Pro Ile Leu Gly Ala 
145                 150                 155                 160 


Glu Ser Glu Pro Glu Lys Thr Gln Ser Gln Ile Ala Ser Gly Phe Phe 
                165                 170                 175     


Thr Phe Ser His Pro Ile Ser Ser Ala Pro Gly Gly Leu Ala Pro Phe 
            180                 185                 190         


Ser Phe Pro Gln Val Thr Ser Ser Ser Ala Thr Thr Ser Asn Phe Thr 
        195                 200                 205             


Phe Ser Lys Pro Val Ser Ser Asn Asn Ser Leu Ser Ala Phe Thr Pro 
    210                 215                 220                 


Ala Leu Ser Asn Gln Asn Val Glu Glu Glu Lys Arg Gly Pro Lys Ser 
225                 230                 235                 240 


Ile Phe Gly Ser Ser Asn Asn Ser Phe Ser Ser Phe Pro Val Ser Ser 
                245                 250                 255     


Ala Val Leu Gly Glu Pro Phe Gln Ala Ser Lys Ala Gly Val Arg Gln 
            260                 265                 270         


Gly Cys Glu Glu Ala Val Ser Gln Val Glu Pro Leu Pro Ser Leu Met 
        275                 280                 285             


Lys Gly Leu Lys Arg Lys Glu Asp Gln Asp Arg Ser Pro Arg Arg His 
    290                 295                 300                 


Gly His Glu Pro Ala Glu Asp Ser Asp Pro Leu Ser Arg Gly Asp His 
305                 310                 315                 320 


Pro Pro Asp Lys Arg Pro Val Arg Leu Asn Arg Pro Arg Gly Gly Thr 
                325                 330                 335     


Leu Phe Gly Arg Thr Ile Gln Asp Val Phe Lys Ser Asn Lys Glu Val 
            340                 345                 350         


Gly Arg Leu Gly Asn Lys Glu Ala Lys Lys Glu Thr Gly Phe Val Glu 
        355                 360                 365             


Ser Ala Glu Ser Asp His Met Ala Ile Pro Gly Gly Asn Gln Ser Val 
    370                 375                 380                 


Leu Ala Pro Ser Arg Ile Pro Gly Val Asn Lys Glu Glu Glu Thr Glu 
385                 390                 395                 400 


Ser Arg Glu Lys Lys Glu Asp Ser Leu Arg Gly Thr Pro Ala Arg Gln 
                405                 410                 415     


Ser Asn Arg Ser Glu Ser Thr Asp Ser Leu Gly Gly Leu Ser Pro Ser 
            420                 425                 430         


Glu Val Thr Ala Ile Gln Cys Lys Asn Ile Pro Asp Tyr Leu Asn Asp 
        435                 440                 445             


Arg Thr Ile Leu Glu Asn His Phe Gly Lys Ile Ala Lys Val Gln Arg 
    450                 455                 460                 


Ile Phe Thr Arg Arg Ser Lys Lys Leu Ala Val Val His Phe Phe Asp 
465                 470                 475                 480 


His Ala Ser Ala Ala Leu Ala Arg Lys Lys Gly Lys Ser Leu His Lys 
                485                 490                 495     


Asp Met Ala Ile Phe Trp His Arg Lys Lys Ile Ser Pro Asn Lys Lys 
            500                 505                 510         


Pro Phe Ser Leu Lys Glu Lys Lys Pro Gly Asp Gly Glu Val Ser Pro 
        515                 520                 525             


Ser Thr Glu Asp Ala Pro Phe Gln His Ser Pro Leu Gly Lys Ala Ala 
    530                 535                 540                 


Gly Arg Thr Gly Ala Ser Ser Leu Leu Asn Lys Ser Ser Pro Val Lys 
545                 550                 555                 560 


Lys Pro Ser Leu Leu Lys Ala His Gln Phe Glu Gly Asp Ser Phe Asp 
                565                 570                 575     


Ser Ala Ser Glu Gly Ser Glu Gly Leu Gly Pro Cys Val Leu Ser Leu 
            580                 585                 590         


Ser Thr Leu Ile Gly Thr Val Ala Glu Thr Ser Lys Glu Lys Tyr Arg 
        595                 600                 605             


Leu Leu Asp Gln Arg Asp Arg Ile Met Arg Gln Ala Arg Val Lys Arg 
    610                 615                 620                 


Thr Asp Leu Asp Lys Ala Arg Thr Phe Val Gly Thr Cys Leu Asp Met 
625                 630                 635                 640 


Cys Pro Glu Lys Glu Arg Tyr Met Arg Glu Thr Arg Ser Gln Leu Ser 
                645                 650                 655     


Val Phe Glu Val Val Pro Gly Thr Asp Gln Val Asp His Ala Ala Ala 
            660                 665                 670         


Val Lys Glu Tyr Ser Arg Ser Ser Ala Asp Gln Glu Glu Pro Leu Pro 
        675                 680                 685             


His Glu Leu Arg Pro Leu Pro Val Leu Ser Arg Thr Met Asp Tyr Leu 
    690                 695                 700                 


Val Thr Gln Ile Met Asp Gln Lys Glu Gly Ser Leu Arg Asp Trp Tyr 
705                 710                 715                 720 


Asp Phe Val Trp Asn Arg Thr Arg Gly Ile Arg Lys Asp Ile Thr Gln 
                725                 730                 735     


Gln His Leu Cys Asp Pro Leu Thr Val Ser Leu Ile Glu Lys Cys Thr 
            740                 745                 750         


Arg Phe His Ile His Cys Ala His Phe Met Cys Glu Glu Pro Met Ser 
        755                 760                 765             


Ser Phe Asp Ala Lys Ile Asn Asn Glu Asn Met Thr Lys Cys Leu Gln 
    770                 775                 780                 


Ser Leu Lys Glu Met Tyr Gln Asp Leu Arg Asn Lys Gly Val Phe Cys 
785                 790                 795                 800 


Ala Ser Glu Ala Glu Phe Gln Gly Tyr Asn Val Leu Leu Ser Leu Asn 
                805                 810                 815     


Lys Gly Asp Ile Leu Arg Glu Val Gln Gln Phe His Pro Ala Val Arg 
            820                 825                 830         


Asn Ser Ser Glu Val Lys Phe Ala Val Gln Ala Phe Ala Ala Leu Asn 
        835                 840                 845             


Ser Asn Asn Phe Val Arg Phe Phe Lys Leu Val Gln Ser Ala Ser Tyr 
    850                 855                 860                 


Leu Asn Ala Cys Leu Leu His Cys Tyr Phe Ser Gln Ile Arg Lys Asp 
865                 870                 875                 880 


Ala Leu Arg Ala Leu Asn Phe Ala Tyr Thr Val Ser Thr Gln Arg Ser 
                885                 890                 895     


Thr Ile Phe Pro Leu Asp Gly Val Val Arg Met Leu Leu Phe Arg Asp 
            900                 905                 910         


Cys Glu Glu Ala Thr Asp Phe Leu Thr Cys His Gly Leu Thr Val Ser 
        915                 920                 925             


Asp Gly Cys Val Glu Leu Asn Arg Ser Ala Phe Leu Glu Pro Glu Gly 
    930                 935                 940                 


Leu Ser Lys Thr Arg Lys Ser Val Phe Ile Thr Arg Lys Leu Thr Val 
945                 950                 955                 960 


Ser Val Gly Glu Ile Val Asn Gly Gly Pro Leu Pro Pro Val Pro Arg 
                965                 970                 975     


His Thr Pro Val Cys Ser Phe Asn Ser Gln Asn Lys Tyr Ile Gly Glu 
            980                 985                 990         


Ser Leu Ala Ala Glu Leu Pro Val  Ser Thr Gln Arg Pro  Gly Ser Asp 
        995                 1000                 1005             


Thr Val  Gly Gly Gly Arg Gly  Glu Glu Cys Gly Val  Glu Pro Asp 
    1010                 1015                 1020             


Ala Pro  Leu Ser Ser Leu Pro  Gln Ser Leu Pro Ala  Pro Ala Pro 
    1025                 1030                 1035             


Ser Pro  Val Pro Leu Pro Pro  Val Leu Ala Leu Thr  Pro Ser Val 
    1040                 1045                 1050             


Ala Pro  Ser Leu Phe Gln Leu  Ser Val Gln Pro Glu  Pro Pro Pro 
    1055                 1060                 1065             


Pro Glu  Pro Val Pro Met Tyr  Ser Asp Glu Asp Leu  Ala Gln Val 
    1070                 1075                 1080             


Val Asp  Glu Leu Ile Gln Glu  Ala Leu Gln Arg Asp  Cys Glu Glu 
    1085                 1090                 1095             


Val Gly  Ser Ala Gly Ala Ala  Tyr Ala Ala Ala Ala  Leu Gly Val 
    1100                 1105                 1110             


Ser Asn  Ala Ala Met Glu Asp  Leu Leu Thr Ala Ala  Thr Thr Gly 
    1115                 1120                 1125             


Ile Leu  Arg His Ile Ala Ala  Glu Glu Val Ser Lys  Glu Arg Glu 
    1130                 1135                 1140             


Arg Arg  Glu Gln Glu Arg Gln  Arg Ala Glu Glu Glu  Arg Leu Lys 
    1145                 1150                 1155             


Gln Glu  Arg Glu Leu Val Leu  Ser Glu Leu Ser Gln  Gly Leu Ala 
    1160                 1165                 1170             


Val Glu  Leu Met Glu Arg Val  Met Met Glu Phe Val  Arg Glu Thr 
    1175                 1180                 1185             


Cys Ser  Gln Glu Leu Lys Asn  Ala Val Glu Thr Asp  Gln Arg Val 
    1190                 1195                 1200             


Arg Val  Ala Arg Cys Cys Glu  Asp Val Cys Ala His  Leu Val Asp 
    1205                 1210                 1215             


Leu Phe  Leu Val Glu Glu Ile  Phe Gln Thr Ala Lys  Glu Thr Leu 
    1220                 1225                 1230             


Gln Glu  Leu Gln Cys Phe Cys  Lys Tyr Leu Gln Arg  Trp Arg Glu 
    1235                 1240                 1245             


Ala Val  Thr Ala Arg Lys Lys  Leu Arg Arg Gln Met  Arg Ala Phe 
    1250                 1255                 1260             


Pro Ala  Ala Pro Cys Cys Val  Asp Val Ser Asp Arg  Leu Arg Ala 
    1265                 1270                 1275             


Leu Ala  Pro Ser Ala Glu Cys  Pro Ile Ala Glu Glu  Asn Leu Ala 
    1280                 1285                 1290             


Arg Gly  Leu Leu Asp Leu Gly  His Ala Gly Arg Leu  Gly Ile Ser 
    1295                 1300                 1305             


Cys Thr  Arg Leu Arg Arg Leu  Arg Asn Lys Thr Ala  His Gln Met 
    1310                 1315                 1320             


Lys Val  Gln His Phe Tyr Gln  Gln Leu Leu Ser Asp  Val Ala Trp 
    1325                 1330                 1335             


Ala Ser  Leu Asp Leu Pro Ser  Leu Val Ala Glu His  Leu Pro Gly 
    1340                 1345                 1350             


Arg Gln  Glu His Val Phe Trp  Lys Leu Val Leu Val  Leu Pro Asp 
    1355                 1360                 1365             


Val Glu  Glu Gln Ser Pro Glu  Ser Cys Gly Arg Ile  Leu Ala Asn 
    1370                 1375                 1380             


Trp Leu  Lys Val Lys Phe Met  Gly Asp Glu Gly Ser  Val Asp Asp 
    1385                 1390                 1395             


Thr Ser  Ser Asp Ala Gly Gly  Ile Gln Thr Leu Ser  Leu Phe Asn 
    1400                 1405                 1410             


Ser Leu  Ser Ser Lys Gly Asp  Gln Met Ile Ser Val  Asn Val Cys 
    1415                 1420                 1425             


Ile Lys  Val Ala His Gly Ala  Leu Ser Asp Gly Ala  Ile Asp Ala 
    1430                 1435                 1440             


Val Glu  Thr Gln Lys Asp Leu  Leu Gly Ala Ser Gly  Leu Met Leu 
    1445                 1450                 1455             


Leu Leu  Pro Pro Lys Met Lys  Ser Glu Asp Met Ala  Glu Glu Asp 
    1460                 1465                 1470             


Val Tyr  Trp Leu Ser Ala Leu  Leu Gln Leu Lys Gln  Leu Leu Gln 
    1475                 1480                 1485             


Ala Lys  Pro Phe Gln Pro Ala  Leu Pro Leu Val Val  Leu Val Pro 
    1490                 1495                 1500             


Ser Pro  Gly Gly Asp Ala Val  Glu Lys Glu Val Glu  Asp Gly Leu 
    1505                 1510                 1515             


Met Leu  Gln Asp Leu Val Ser  Ala Lys Leu Ile Ser  Asp Tyr Thr 
    1520                 1525                 1530             


Val Thr  Glu Ile Pro Asp Thr  Ile Asn Asp Leu Gln  Gly Ser Thr 
    1535                 1540                 1545             


Lys Val  Leu Gln Ala Val Gln  Trp Leu Val Ser His  Cys Pro His 
    1550                 1555                 1560             


Ser Leu  Asp Leu Cys Cys Gln  Thr Leu Ile Gln Tyr  Val Glu Asp 
    1565                 1570                 1575             


Gly Ile  Gly His Glu Phe Ser  Gly Arg Phe Phe His  Asp Arg Arg 
    1580                 1585                 1590             


Glu Arg  Arg Leu Gly Gly Leu  Ala Ser Gln Glu Pro  Gly Ala Ile 
    1595                 1600                 1605             


Ile Glu  Leu Phe Asn Ser Val  Leu Gln Phe Leu Ala  Ser Val Val 
    1610                 1615                 1620             


Ser Ser  Glu Gln Leu Cys Asp  Leu Ser Trp Pro Val  Thr Glu Phe 
    1625                 1630                 1635             


Ala Glu  Ala Gly Gly Ser Arg  Leu Leu Pro His Leu  His Trp Asn 
    1640                 1645                 1650             


Ala Pro  Glu His Leu Ala Trp  Leu Lys Gln Ala Val  Leu Gly Phe 
    1655                 1660                 1665             


Gln Leu  Pro Gln Met Asp Leu  Pro Pro Leu Gly Ala  Pro Trp Leu 
    1670                 1675                 1680             


Pro Val  Cys Ser Met Val Val  Gln Tyr Ala Ser Gln  Ile Pro Ser 
    1685                 1690                 1695             


Ser Arg  Gln Thr Gln Pro Val  Leu Gln Ser Gln Val  Glu Asn Leu 
    1700                 1705                 1710             


Leu His  Arg Thr Tyr Cys Arg  Trp Lys Ser Lys Ser  Pro Ser Pro 
    1715                 1720                 1725             


Val His  Gly Ala Gly Pro Ser  Val Met Glu Ile Pro  Trp Asp Asp 
    1730                 1735                 1740             


Leu Ile  Ala Leu Cys Ile Asn  His Lys Leu Arg Asp  Trp Thr Pro 
    1745                 1750                 1755             


Pro Arg  Leu Pro Val Thr Ser  Glu Ala Leu Ser Glu  Asp Gly Gln 
    1760                 1765                 1770             


Ile Cys  Val Tyr Phe Phe Lys  Asn Asp Leu Lys Lys  Tyr Asp Val 
    1775                 1780                 1785             


Pro Leu  Ser Trp Glu Gln Ala  Arg Leu Gln Thr Gln  Lys Glu Leu 
    1790                 1795                 1800             


Gln Leu  Arg Glu Gly Arg Leu  Ala Ile Lys Pro Phe  His Pro Ser 
    1805                 1810                 1815             


Ala Asn  Asn Phe Pro Ile Pro  Leu Leu His Met His  Arg Asn Trp 
    1820                 1825                 1830             


Lys Arg  Ser Thr Glu Cys Ala  Gln Glu Gly Arg Ile  Pro Ser Thr 
    1835                 1840                 1845             


Glu Asp  Leu Met Arg Gly Ala  Ser Ala Glu Glu Leu  Leu Ala Gln 
    1850                 1855                 1860             


Cys Leu  Ser Ser Ser Leu Leu  Leu Glu Lys Glu Glu  Asn Lys Arg 
    1865                 1870                 1875             


Phe Glu  Asp Gln Leu Gln Gln  Trp Leu Ser Glu Asp  Ser Gly Ala 
    1880                 1885                 1890             


Phe Thr  Asp Leu Thr Ser Leu  Pro Leu Tyr Leu Pro  Gln Thr Leu 
    1895                 1900                 1905             


Val Ser  Leu Ser His Thr Ile  Glu Pro Val Met Lys  Thr Ser Val 
    1910                 1915                 1920             


Thr Thr  Ser Pro Gln Ser Asp  Met Met Arg Glu Gln  Leu Gln Leu 
    1925                 1930                 1935             


Ser Glu  Ala Thr Gly Thr Cys  Leu Gly Glu Arg Leu  Lys His Leu 
    1940                 1945                 1950             


Glu Arg  Leu Ile Arg Ser Ser  Arg Glu Glu Glu Val  Ala Ser Glu 
    1955                 1960                 1965             


Leu His  Leu Ser Ala Leu Leu  Asp Met Val Asp Ile  
    1970                 1975                 1980 


<210> 5127
<211> 1048
<212> PRT
<213> Homo sapiens

<400> 5127
Met Ser Asp Val Asn Pro Pro Ser Asp Thr Pro Ile Pro Phe Ser Ser 
1               5                   10                  15      


Ser Ser Thr His Ser Ser His Ile Pro Pro Trp Thr Phe Ser Cys Tyr 
            20                  25                  30          


Pro Gly Ser Pro Cys Glu Asn Gly Val Met Leu Tyr Met Arg Asn Val 
        35                  40                  45              


Ser His Glu Glu Leu Gln Arg Phe Lys Gln Leu Leu Leu Thr Glu Leu 
    50                  55                  60                  


Ser Thr Gly Thr Met Pro Ile Thr Trp Asp Gln Val Glu Thr Ala Ser 
65                  70                  75                  80  


Trp Ala Glu Val Val His Leu Leu Ile Glu Arg Phe Pro Gly Arg Arg 
                85                  90                  95      


Ala Trp Asp Val Thr Ser Asn Ile Phe Ala Ile Met Asn Cys Asp Lys 
            100                 105                 110         


Met Cys Val Val Val Arg Arg Glu Ile Asn Ala Ile Leu Pro Thr Leu 
        115                 120                 125             


Glu Pro Glu Asp Leu Asn Val Gly Glu Thr Gln Val Asn Leu Glu Glu 
    130                 135                 140                 


Gly Glu Ser Gly Lys Ile Arg Arg Tyr Lys Ser Asn Val Met Glu Lys 
145                 150                 155                 160 


Phe Phe Pro Ile Trp Asp Ile Thr Thr Trp Pro Gly Asn Gln Arg Asp 
                165                 170                 175     


Phe Phe Tyr Gln Gly Val His Arg His Glu Glu Tyr Leu Pro Cys Leu 
            180                 185                 190         


Leu Leu Pro Lys Arg Pro Gln Gly Arg Gln Pro Lys Thr Val Ala Ile 
        195                 200                 205             


Gln Gly Ala Pro Gly Ile Gly Lys Thr Ile Leu Ala Lys Lys Val Met 
    210                 215                 220                 


Phe Glu Trp Ala Arg Asn Lys Phe Tyr Ala His Lys Arg Trp Cys Ala 
225                 230                 235                 240 


Phe Tyr Phe His Cys Gln Glu Val Asn Gln Thr Thr Asp Gln Ser Phe 
                245                 250                 255     


Ser Glu Leu Ile Glu Gln Lys Trp Pro Gly Ser Gln Asp Leu Val Ser 
            260                 265                 270         


Lys Ile Met Ser Lys Pro Asp Gln Leu Leu Leu Leu Leu Asp Gly Phe 
        275                 280                 285             


Glu Glu Leu Thr Ser Thr Leu Ile Asp Arg Leu Glu Asp Leu Ser Glu 
    290                 295                 300                 


Asp Trp Arg Gln Lys Leu Pro Gly Ser Val Leu Leu Ser Ser Leu Leu 
305                 310                 315                 320 


Ser Lys Thr Met Leu Pro Glu Ala Thr Leu Leu Ile Met Ile Arg Phe 
                325                 330                 335     


Thr Ser Trp Gln Thr Cys Lys Pro Leu Leu Lys Cys Pro Ser Leu Val 
            340                 345                 350         


Thr Leu Pro Gly Phe Asn Thr Met Glu Lys Ile Lys Tyr Phe Gln Met 
        355                 360                 365             


Tyr Phe Gly His Thr Glu Glu Gly Asp Gln Val Leu Ser Phe Ala Met 
    370                 375                 380                 


Glu Asn Thr Ile Leu Phe Ser Met Cys Arg Val Pro Val Val Cys Trp 
385                 390                 395                 400 


Met Val Cys Ser Gly Leu Lys Gln Gln Met Glu Arg Gly Asn Asn Leu 
                405                 410                 415     


Thr Gln Ser Cys Pro Asn Ala Thr Ser Val Phe Val Arg Tyr Ile Ser 
            420                 425                 430         


Ser Leu Phe Pro Thr Arg Ala Glu Asn Phe Ser Arg Lys Ile His Gln 
        435                 440                 445             


Ala Gln Leu Glu Gly Leu Cys His Leu Ala Ala Asp Ser Met Trp His 
    450                 455                 460                 


Arg Lys Trp Val Leu Gly Lys Glu Asp Leu Glu Glu Ala Lys Leu Asp 
465                 470                 475                 480 


Gln Thr Gly Val Thr Ala Phe Leu Gly Met Ser Ile Leu Arg Arg Ile 
                485                 490                 495     


Ala Gly Glu Glu Asp His Tyr Val Phe Thr Leu Val Thr Phe Gln Glu 
            500                 505                 510         


Phe Phe Ala Ala Leu Phe Tyr Val Leu Cys Phe Pro Gln Arg Leu Lys 
        515                 520                 525             


Asn Phe His Val Leu Ser His Val Asn Ile Gln Arg Leu Ile Ala Ser 
    530                 535                 540                 


Pro Arg Gly Ser Lys Ser Tyr Leu Ser His Met Gly Leu Phe Leu Phe 
545                 550                 555                 560 


Gly Phe Leu Asn Glu Ala Cys Ala Ser Ala Val Glu Gln Ser Phe Gln 
                565                 570                 575     


Cys Lys Val Ser Phe Gly Asn Lys Arg Lys Leu Leu Lys Val Ile Pro 
            580                 585                 590         


Leu Leu His Lys Cys Asp Pro Pro Ser Pro Gly Ser Gly Val Pro Gln 
        595                 600                 605             


Leu Phe Tyr Cys Leu His Glu Ile Arg Glu Glu Ala Phe Val Ser Gln 
    610                 615                 620                 


Ala Leu Asn Asp Tyr His Lys Val Val Leu Arg Ile Gly Asn Asn Lys 
625                 630                 635                 640 


Glu Val Gln Val Ser Ala Phe Cys Leu Lys Arg Cys Gln Tyr Leu His 
                645                 650                 655     


Glu Val Glu Leu Thr Val Thr Leu Asn Phe Met Asn Val Trp Lys Leu 
            660                 665                 670         


Ser Ser Ser Ser His Pro Gly Ser Glu Ala Pro Glu Ser Asn Gly Leu 
        675                 680                 685             


His Arg Trp Trp Gln Asp Leu Cys Ser Val Phe Ala Thr Asn Asp Lys 
    690                 695                 700                 


Leu Glu Val Leu Thr Met Thr Asn Ser Val Leu Gly Pro Pro Phe Leu 
705                 710                 715                 720 


Lys Ala Leu Ala Ala Ala Leu Arg His Pro Gln Cys Lys Leu Gln Lys 
                725                 730                 735     


Leu Leu Leu Arg Arg Val Asn Ser Thr Met Leu Asn Gln Asp Leu Ile 
            740                 745                 750         


Gly Val Leu Thr Gly Asn Gln His Leu Arg Tyr Leu Glu Ile Gln His 
        755                 760                 765             


Val Glu Val Glu Ser Lys Ala Val Lys Leu Leu Cys Arg Val Leu Arg 
    770                 775                 780                 


Ser Pro Arg Cys Arg Leu Gln Cys Leu Arg Leu Glu Asp Cys Leu Ala 
785                 790                 795                 800 


Thr Pro Arg Ile Trp Thr Asp Leu Gly Asn Asn Leu Gln Gly Asn Gly 
                805                 810                 815     


His Leu Lys Thr Leu Ile Leu Arg Lys Asn Ser Leu Glu Asn Cys Gly 
            820                 825                 830         


Ala Tyr Tyr Leu Ser Val Ala Gln Leu Glu Arg Leu Ser Ile Glu Asn 
        835                 840                 845             


Cys Asn Leu Thr Gln Leu Thr Cys Glu Ser Leu Ala Ser Cys Leu Arg 
    850                 855                 860                 


Gln Ser Lys Met Leu Thr His Leu Ser Leu Ala Glu Asn Ala Leu Lys 
865                 870                 875                 880 


Asp Glu Gly Ala Lys His Ile Trp Asn Ala Leu Pro His Leu Arg Cys 
                885                 890                 895     


Pro Leu Gln Arg Leu Val Leu Arg Lys Cys Asp Leu Thr Phe Asn Cys 
            900                 905                 910         


Cys Gln Asp Met Ile Ser Ala Leu Cys Lys Asn Lys Thr Leu Lys Ser 
        915                 920                 925             


Leu Asp Leu Ser Phe Asn Ser Leu Lys Asp Asp Gly Val Ile Leu Leu 
    930                 935                 940                 


Cys Glu Ala Leu Lys Asn Pro Asp Cys Thr Leu Gln Ile Leu Glu Leu 
945                 950                 955                 960 


Glu Asn Cys Leu Phe Thr Ser Ile Cys Cys Gln Ala Met Ala Ser Met 
                965                 970                 975     


Leu Arg Lys Asn Gln His Leu Arg His Leu Asp Leu Ser Lys Asn Ala 
            980                 985                 990         


Ile Gly Val Tyr Gly Ile Leu Thr  Leu Cys Glu Ala Phe  Ser Ser Gln 
        995                 1000                 1005             


Lys Lys  Arg Glu Glu Val Ile  Phe Cys Ile Pro Ala  Trp Thr Arg 
    1010                 1015                 1020             


Ile Thr  Ser Phe Ser Pro Thr  Pro His Pro Pro Asp  Phe Thr Gly 
    1025                 1030                 1035             


Lys Ser  Asp Cys Leu Ser Gln  Ile Asn Pro 
    1040                 1045             


<210> 5128
<211> 1263
<212> PRT
<213> Homo sapiens

<400> 5128
Met Pro Ala Arg Ile Gly Tyr Tyr Glu Ile Asp Arg Thr Ile Gly Lys 
1               5                   10                  15      


Gly Asn Phe Ala Val Val Lys Arg Ala Thr His Leu Val Thr Lys Ala 
            20                  25                  30          


Lys Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asp Glu Glu Asn 
        35                  40                  45              


Leu Lys Lys Ile Phe Arg Glu Val Gln Ile Met Lys Met Leu Cys His 
    50                  55                  60                  


Pro His Ile Ile Arg Leu Tyr Gln Val Met Glu Thr Glu Arg Met Ile 
65                  70                  75                  80  


Tyr Leu Val Thr Glu Tyr Ala Ser Gly Gly Glu Ile Phe Asp His Leu 
                85                  90                  95      


Val Ala His Gly Arg Met Ala Glu Lys Glu Ala Arg Arg Lys Phe Lys 
            100                 105                 110         


Gln Ile Val Thr Ala Val Tyr Phe Cys His Cys Arg Asn Ile Val His 
        115                 120                 125             


Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Asn Leu Asn Ile 
    130                 135                 140                 


Lys Ile Ala Asp Phe Gly Phe Ser Asn Leu Phe Thr Pro Gly Gln Leu 
145                 150                 155                 160 


Leu Lys Thr Trp Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe 
                165                 170                 175     


Glu Gly Lys Glu Tyr Asp Gly Pro Lys Val Asp Ile Trp Ser Leu Gly 
            180                 185                 190         


Val Val Leu Tyr Val Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Ser 
        195                 200                 205             


Thr Leu Gln Asn Leu Arg Ala Arg Val Leu Ser Gly Lys Phe Arg Ile 
    210                 215                 220                 


Pro Phe Phe Met Ser Thr Glu Cys Glu His Leu Ile Arg His Met Leu 
225                 230                 235                 240 


Val Leu Asp Pro Asn Lys Arg Leu Ser Met Glu Gln Ile Cys Lys His 
                245                 250                 255     


Lys Trp Met Lys Leu Gly Asp Ala Asp Pro Asn Phe Asp Arg Leu Ile 
            260                 265                 270         


Ala Glu Cys Gln Gln Leu Lys Glu Glu Arg Gln Val Asp Pro Leu Asn 
        275                 280                 285             


Glu Asp Val Leu Leu Ala Met Glu Asp Met Gly Leu Asp Lys Glu Gln 
    290                 295                 300                 


Thr Leu Gln Ser Leu Arg Ser Asp Ala Tyr Asp His Tyr Ser Ala Ile 
305                 310                 315                 320 


Tyr Ser Leu Leu Cys Asp Arg His Lys Arg His Lys Thr Leu Arg Leu 
                325                 330                 335     


Gly Ala Leu Pro Ser Met Pro Arg Ala Leu Ala Phe Gln Ala Pro Val 
            340                 345                 350         


Asn Ile Gln Ala Glu Gln Ala Gly Thr Ala Met Asn Ile Ser Val Pro 
        355                 360                 365             


Gln Val Gln Leu Ile Asn Pro Glu Asn Gln Ile Val Glu Pro Asp Gly 
    370                 375                 380                 


Thr Leu Asn Leu Asp Ser Asp Glu Gly Glu Glu Pro Ser Pro Glu Ala 
385                 390                 395                 400 


Leu Val Arg Tyr Leu Ser Met Arg Arg His Thr Val Gly Val Ala Asp 
                405                 410                 415     


Pro Arg Thr Glu Val Met Glu Asp Leu Gln Lys Leu Leu Pro Gly Phe 
            420                 425                 430         


Pro Gly Val Asn Pro Gln Ala Pro Phe Leu Gln Val Ala Pro Asn Val 
        435                 440                 445             


Asn Phe Met His Asn Leu Leu Pro Met Gln Asn Leu Gln Pro Thr Gly 
    450                 455                 460                 


Gln Leu Glu Tyr Lys Glu Gln Ser Leu Leu Gln Pro Pro Thr Leu Gln 
465                 470                 475                 480 


Leu Leu Asn Gly Met Gly Pro Leu Gly Arg Arg Ala Ser Asp Gly Gly 
                485                 490                 495     


Ala Asn Ile Gln Leu His Ala Gln Gln Leu Leu Lys Arg Pro Arg Gly 
            500                 505                 510         


Pro Ser Pro Leu Val Thr Met Thr Pro Ala Val Pro Ala Val Thr Pro 
        515                 520                 525             


Val Asp Glu Glu Ser Ser Asp Gly Glu Pro Asp Gln Glu Ala Val Gln 
    530                 535                 540                 


Ser Ser Thr Tyr Lys Asp Ser Asn Thr Leu His Leu Pro Thr Glu Arg 
545                 550                 555                 560 


Phe Ser Pro Val Arg Arg Phe Ser Asp Gly Ala Ala Ser Ile Gln Ala 
                565                 570                 575     


Phe Lys Ala His Leu Glu Lys Met Gly Asn Asn Ser Ser Ile Lys Gln 
            580                 585                 590         


Leu Gln Gln Glu Cys Glu Gln Leu Gln Lys Met Tyr Gly Gly Gln Ile 
        595                 600                 605             


Asp Glu Arg Thr Leu Glu Lys Thr Gln Gln Gln His Met Leu Tyr Gln 
    610                 615                 620                 


Gln Glu Gln His His Gln Ile Leu Gln Gln Gln Ile Gln Asp Ser Ile 
625                 630                 635                 640 


Cys Pro Pro Gln Pro Ser Pro Pro Leu Gln Ala Ala Cys Glu Asn Gln 
                645                 650                 655     


Pro Ala Leu Leu Thr His Gln Leu Gln Arg Leu Arg Ile Gln Pro Ser 
            660                 665                 670         


Ser Pro Pro Pro Asn His Pro Asn Asn His Leu Phe Arg Gln Pro Ser 
        675                 680                 685             


Asn Ser Pro Pro Pro Met Ser Ser Ala Met Ile Gln Pro His Gly Ala 
    690                 695                 700                 


Ala Ser Ser Ser Gln Phe Gln Gly Leu Pro Ser Arg Ser Ala Ile Phe 
705                 710                 715                 720 


Gln Gln Gln Pro Glu Asn Cys Ser Ser Pro Pro Asn Val Ala Leu Thr 
                725                 730                 735     


Cys Leu Gly Met Gln Gln Pro Ala Gln Ser Gln Gln Val Thr Ile Gln 
            740                 745                 750         


Val Gln Glu Pro Val Asp Met Leu Ser Asn Met Pro Gly Thr Ala Ala 
        755                 760                 765             


Gly Ser Ser Gly Arg Gly Ile Ser Ile Ser Pro Ser Ala Gly Gln Met 
    770                 775                 780                 


Gln Met Gln His Arg Thr Asn Leu Met Ala Thr Leu Ser Tyr Gly His 
785                 790                 795                 800 


Arg Pro Leu Ser Lys Gln Leu Ser Ala Asp Ser Ala Glu Ala His Ser 
                805                 810                 815     


Leu Asn Val Asn Arg Phe Ser Pro Ala Asn Tyr Asp Gln Ala His Leu 
            820                 825                 830         


His Pro His Leu Phe Ser Asp Gln Ser Arg Gly Ser Pro Ser Ser Tyr 
        835                 840                 845             


Ser Pro Ser Thr Gly Val Gly Phe Ser Pro Thr Gln Ala Leu Lys Val 
    850                 855                 860                 


Pro Pro Leu Asp Gln Phe Pro Thr Phe Pro Pro Ser Ala His Gln Gln 
865                 870                 875                 880 


Pro Pro His Tyr Thr Thr Ser Ala Leu Gln Gln Ala Leu Leu Ser Pro 
                885                 890                 895     


Thr Pro Pro Asp Tyr Thr Arg His Gln Gln Val Pro His Ile Leu Gln 
            900                 905                 910         


Gly Leu Leu Ser Pro Arg His Ser Leu Thr Gly His Ser Asp Ile Arg 
        915                 920                 925             


Leu Pro Pro Thr Glu Phe Ala Gln Leu Ile Lys Arg Gln Gln Gln Gln 
    930                 935                 940                 


Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Tyr Gln Glu Leu 
945                 950                 955                 960 


Phe Arg His Met Asn Gln Gly Asp Ala Gly Ser Leu Ala Pro Ser Leu 
                965                 970                 975     


Gly Gly Gln Ser Met Thr Glu Arg Gln Ala Leu Ser Tyr Gln Asn Ala 
            980                 985                 990         


Asp Ser Tyr His His His Thr Ser  Pro Gln His Leu Leu  Gln Ile Arg 
        995                 1000                 1005             


Ala Gln  Glu Cys Val Ser Gln  Ala Ser Ser Pro Thr  Pro Pro His 
    1010                 1015                 1020             


Gly Tyr  Ala His Gln Pro Ala  Leu Met His Ser Glu  Ser Met Glu 
    1025                 1030                 1035             


Glu Asp  Cys Ser Cys Glu Gly  Ala Lys Asp Gly Phe  Gln Asp Ser 
    1040                 1045                 1050             


Lys Ser  Ser Ser Thr Leu Thr  Lys Gly Cys His Asp  Ser Pro Leu 
    1055                 1060                 1065             


Leu Leu  Ser Thr Gly Gly Pro  Gly Asp Pro Glu Ser  Leu Leu Gly 
    1070                 1075                 1080             


Thr Val  Ser His Ala Gln Glu  Leu Gly Ile His Pro  Tyr Gly His 
    1085                 1090                 1095             


Gln Pro  Thr Ala Ala Phe Ser  Lys Asn Lys Val Pro  Ser Arg Glu 
    1100                 1105                 1110             


Pro Val  Ile Gly Asn Cys Met  Asp Arg Ser Ser Pro  Gly Gln Ala 
    1115                 1120                 1125             


Val Glu  Leu Pro Asp His Asn  Gly Leu Gly Tyr Pro  Ala Arg Pro 
    1130                 1135                 1140             


Ser Val  His Glu His His Arg  Pro Arg Ala Leu Gln  Arg His His 
    1145                 1150                 1155             


Thr Ile  Gln Asn Ser Asp Asp  Ala Tyr Val Gln Leu  Asp Asn Leu 
    1160                 1165                 1170             


Pro Gly  Met Ser Leu Val Ala  Gly Lys Ala Leu Ser  Ser Ala Arg 
    1175                 1180                 1185             


Met Ser  Asp Ala Val Leu Ser  Gln Ser Ser Leu Met  Gly Ser Gln 
    1190                 1195                 1200             


Gln Phe  Gln Asp Gly Glu Asn  Glu Glu Cys Gly Ala  Ser Leu Gly 
    1205                 1210                 1215             


Gly His  Glu His Pro Asp Leu  Ser Asp Gly Ser Gln  His Leu Asn 
    1220                 1225                 1230             


Ser Ser  Cys Tyr Pro Ser Thr  Cys Ile Thr Asp Ile  Leu Leu Ser 
    1235                 1240                 1245             


Tyr Lys  His Pro Glu Val Ser  Phe Ser Met Glu Gln  Ala Gly Val 
    1250                 1255                 1260             


<210> 5129
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 5129
Met Tyr Gln Pro Glu Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp 
1               5                   10                  15      


Asp Met Thr Arg Asn Arg Arg Glu Ser Ser Pro Pro His Ser Val His 
            20                  25                  30          


Ser Phe Ser Gly Asp Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp 
        35                  40                  45              


Met Glu Pro Arg Asp Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg 
    50                  55                  60                  


Met Pro Pro Arg Asp Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe 
65                  70                  75                  80  


Glu Met Asp Arg Glu Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg 
                85                  90                  95      


Ser Gln Asp Ala Glu Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp 
            100                 105                 110         


Arg Lys Pro His Asn Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys 
        115                 120                 125             


Leu Leu Ser Leu Gly Val Gln Leu Ala Glu Asp Asp Gly His Ser His 
    130                 135                 140                 


Met Thr Gln Gly His Ser Ser Arg Ser Lys Arg Ser Ala Tyr Pro Ser 
145                 150                 155                 160 


Thr Ser Arg Gly Leu Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His 
                165                 170                 175     


Arg Arg Gly Ile Cys Glu Asp Glu Ser Ser His Gly Val Ile Met Glu 
            180                 185                 190         


Lys Phe Ile Lys Asp Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg 
        195                 200                 205             


Glu Ser Ser Asp Arg Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn 
    210                 215                 220                 


Trp Lys Asp Ile Ser Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg 
225                 230                 235                 240 


Val Tyr Glu Gly Asn Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr 
                245                 250                 255     


Leu Val Ser Arg Lys Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe 
            260                 265                 270         


Asp Thr Asp Gly Lys Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg 
        275                 280                 285             


Lys Lys Pro Phe Glu Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val 
    290                 295                 300                 


Ser Ser Leu Ser Ser Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro 
305                 310                 315                 320 


Ile Asp Phe Gly Ala Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser 
                325                 330                 335     


Phe Ser Val Ile Ser Glu Phe Val Glu His Gln Ile Met His Thr Arg 
            340                 345                 350         


Glu Asn Leu Tyr Glu Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val 
        355                 360                 365             


Ser Glu Val Gln Lys Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys 
    370                 375                 380                 


Asp Cys Gly Glu Thr Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg 
385                 390                 395                 400 


Lys Ile His Ala Arg Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys 
                405                 410                 415     


Glu Glu Ala Phe Met Pro Ser Pro Thr Phe Ser Glu Leu Gln Lys Ile 
            420                 425                 430         


Tyr Gly Lys Asp Lys Phe Tyr Glu Cys Arg Val Cys Lys Glu Thr Phe 
        435                 440                 445             


Leu His Ser Ser Ala Leu Ile Glu His Gln Lys Ile His Phe Gly Asp 
    450                 455                 460                 


Asp Lys Asp Asn Glu Arg Glu His Glu Arg Glu Arg Glu Arg Glu Arg 
465                 470                 475                 480 


Gly Glu Thr Phe Arg Pro Ser Pro Ala Leu Asn Glu Phe Gln Lys Met 
                485                 490                 495     


Tyr Gly Lys Glu Lys Met Tyr Glu Cys Lys Val Cys Gly Glu Thr Phe 
            500                 505                 510         


Leu His Ser Ser Ser Leu Lys Glu His Gln Lys Ile His Thr Arg Gly 
        515                 520                 525             


Asn Pro Phe Glu Asn Lys Gly Lys Val Cys Glu Glu Thr Phe Ile Pro 
    530                 535                 540                 


Gly Gln Ser Leu Lys Arg Arg Gln Lys Thr Tyr Asn Lys Glu Lys Leu 
545                 550                 555                 560 


Cys Asp Phe Thr Asp Gly Arg Asp Ala Phe Met Gln Ser Ser Glu Leu 
                565                 570                 575     


Ser Glu His Gln Lys Ile His Ser Arg Lys Asn Leu Phe Glu Gly Arg 
            580                 585                 590         


Gly Tyr Glu Lys Ser Val Ile His Ser Gly Pro Phe Thr Glu Ser Gln 
        595                 600                 605             


Lys Ser His Thr Ile Thr Arg Pro Leu Glu Ser Asp Glu Asp Glu Lys 
    610                 615                 620                 


Ala Phe Thr Ile Ser Ser Asn Pro Tyr Glu Asn Gln Lys Ile Pro Thr 
625                 630                 635                 640 


Lys Glu Asn Val Tyr Glu Ala Lys Ser Tyr Glu Arg Ser Val Ile His 
                645                 650                 655     


Ser Leu Ala Ser Val Glu Ala Gln Lys Ser His Ser Val Ala Gly Pro 
            660                 665                 670         


Ser Lys Pro Lys Val Met Ala Glu Ser Thr Ile Gln Ser Phe Asp Ala 
        675                 680                 685             


Ile Asn His Gln Arg Val Arg Ala Gly Gly Asn Thr Ser Glu Gly Arg 
    690                 695                 700                 


Glu Tyr Ser Arg Ser Val Ile His Ser Leu Val Ala Ser Lys Pro Pro 
705                 710                 715                 720 


Arg Ser His Asn Gly Asn Glu Leu Val Glu Ser Asn Glu Lys Gly Glu 
                725                 730                 735     


Ser Ser Ile Tyr Ile Ser Asp Leu Asn Asp Lys Arg Gln Lys Ile Pro 
            740                 745                 750         


Ala Arg Glu Asn Pro Cys Glu Gly Gly Ser Lys Asn Arg Asn Tyr Glu 
        755                 760                 765             


Asp Ser Val Ile Gln Ser Val Phe Arg Ala Lys Pro Gln Lys Ser Val 
    770                 775                 780                 


Pro Gly Glu Gly Ser Gly Glu Phe Lys Lys Asp Gly Glu Phe Ser Val 
785                 790                 795                 800 


Pro Ser Ser Asn Val Arg Glu Tyr Gln Lys Ala Arg Ala Lys Lys Lys 
                805                 810                 815     


Tyr Ile Glu His Arg Ser Asn Glu Thr Ser Val Ile His Ser Leu Pro 
            820                 825                 830         


Phe Gly Glu Gln Thr Phe Arg Pro Arg Gly Met Leu Tyr Glu Cys Gln 
        835                 840                 845             


Glu Cys Gly Glu Cys Phe Ala His Ser Ser Asp Leu Thr Glu His Gln 
    850                 855                 860                 


Lys Ile His Asp Arg Glu Lys Pro Ser Gly Ser Arg Asn Tyr Glu Trp 
865                 870                 875                 880 


Ser Val Ile Arg Ser Leu Ala Pro Thr Asp Pro Gln Thr Ser Tyr Ala 
                885                 890                 895     


Gln Glu Gln Tyr Ala Lys Glu Gln Ala Arg Asn Lys Cys Lys Asp Phe 
            900                 905                 910         


Arg Gln Phe Phe Ala Thr Ser Glu Asp Leu Asn Thr Asn Gln Lys Ile 
        915                 920                 925             


Tyr Asp Gln Glu Lys Ser His Gly Glu Glu Ser Gln Gly Glu Asn Thr 
    930                 935                 940                 


Asp Gly Glu Glu Thr His Ser Glu Glu Thr His Gly Gln Glu Thr Ile 
945                 950                 955                 960 


Glu Asp Pro Val Ile Gln Gly Ser Asp Met Glu Asp Pro Gln Lys Asp 
                965                 970                 975     


Asp Pro Asp Asp Lys Ile Tyr Glu Cys Glu Asp Cys Gly Leu Gly Phe 
            980                 985                 990         


Val Asp Leu Thr Asp Leu Thr Asp  His Gln Lys Val His  Ser Arg Lys 
        995                 1000                 1005             


Cys Leu  Val Asp Ser Arg Glu  Tyr Thr His Ser Val  Ile His Thr 
    1010                 1015                 1020             


His Ser  Ile Ser Glu Tyr Gln  Arg Asp Tyr Thr Gly  Glu Gln Leu 
    1025                 1030                 1035             


Tyr Glu  Cys Pro Lys Cys Gly  Glu Ser Phe Ile His  Ser Ser Phe 
    1040                 1045                 1050             


Leu Phe  Glu His Gln Arg Ile  His Glu Gln Asp Gln  Leu Tyr Ser 
    1055                 1060                 1065             


Met Lys  Gly Cys Asp Asp Gly  Phe Ile Ala Leu Leu  Pro Met Lys 
    1070                 1075                 1080             


Pro Arg  Arg Asn Arg Ala Ala  Glu Arg Asn Pro Ala  Leu Ala Gly 
    1085                 1090                 1095             


Ser Ala  Ile Arg Cys Leu Leu  Cys Gly Gln Gly Phe  Ile His Ser 
    1100                 1105                 1110             


Ser Ala  Leu Asn Glu His Met  Arg Leu His Arg Glu  Asp Asp Leu 
    1115                 1120                 1125             


Leu Glu  Gln Ser Gln Met Ala  Glu Glu Ala Ile Ile  Pro Gly Leu 
    1130                 1135                 1140             


Ala Leu  Thr Glu Phe Gln Arg  Ser Gln Thr Glu Glu  Arg Leu Phe 
    1145                 1150                 1155             


Glu Cys  Ala Val Cys Gly Glu  Ser Phe Val Asn Pro  Ala Glu Leu 
    1160                 1165                 1170             


Ala Asp  His Val Thr Val His  Lys Asn Glu Pro Tyr  Glu Tyr Gly 
    1175                 1180                 1185             


Ser Ser  Tyr Thr His Thr Ser  Phe Leu Thr Glu Pro  Leu Lys Gly 
    1190                 1195                 1200             


Ala Ile  Pro Phe Tyr Glu Cys  Lys Asp Cys Gly Lys  Ser Phe Ile 
    1205                 1210                 1215             


His Ser  Thr Val Leu Thr Lys  His Lys Glu Leu His  Leu Glu Glu 
    1220                 1225                 1230             


Glu Glu  Glu Asp Glu Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Gln 
    1235                 1240                 1245             


Glu Val  Glu Ala Asn Val His  Val Pro Gln Val Val  Leu Arg Ile 
    1250                 1255                 1260             


Gln Gly  Leu Asn Val Glu Ala  Ala Glu Pro Glu Val  Glu Ala Ala 
    1265                 1270                 1275             


Glu Pro  Glu Val Glu Ala Ala  Glu Pro Glu Val Glu  Ala Ala Glu 
    1280                 1285                 1290             


Pro Asn  Gly Glu Ala Glu Gly  Pro Asp Gly Glu Ala  Ala Glu Pro 
    1295                 1300                 1305             


Ile Gly  Glu Ala Gly Gln Pro  Asn Gly Glu Ala Glu  Gln Pro Asn 
    1310                 1315                 1320             


Gly Asp  Ala Asp Glu Pro Asp  Gly Ala Gly Ile Glu  Asp Pro Glu 
    1325                 1330                 1335             


Glu Arg  Ala Glu Glu Pro Glu  Gly Lys Ala Glu Glu  Pro Glu Gly 
    1340                 1345                 1350             


Asp Ala  Asp Glu Pro Asp Gly  Val Gly Ile Glu Asp  Pro Glu Glu 
    1355                 1360                 1365             


Gly Glu  Asp Gln Glu Ile Gln  Val Glu Glu Pro Tyr  Tyr Asp Cys 
    1370                 1375                 1380             


His Glu  Cys Thr Glu Thr Phe  Thr Ser Ser Thr Ala  Phe Ser Glu 
    1385                 1390                 1395             


His Leu  Lys Thr His Ala Ser  Met Ile Ile Phe Glu  Pro Ala Asn 
    1400                 1405                 1410             


Ala Phe  Gly Glu Cys Ser Gly  Tyr Ile Glu Arg Ala  Ser Thr Ser 
    1415                 1420                 1425             


Thr Gly  Gly Ala Asn Gln Ala  Asp Glu Lys Tyr Phe  Lys Cys Asp 
    1430                 1435                 1440             


Val Cys  Gly Gln Leu Phe Asn  Asp Arg Leu Ser Leu  Ala Arg His 
    1445                 1450                 1455             


Gln Asn  Thr His Thr Gly 
    1460                 


<210> 5130
<211> 433
<212> PRT
<213> Homo sapiens

<400> 5130
Met Ala Glu Ala Gln Ser Gly Thr Gly Gln Leu Gln Glu Gln Lys Lys 
1               5                   10                  15      


Gly Leu Leu Ile Ala Val Ser Val Ser Val Asp Lys Ile Ile Ser His 
            20                  25                  30          


Phe Gly Ala Ala Arg Asn Leu Val Gln Lys Ala Gln Leu Gly Asp Ser 
        35                  40                  45              


Arg Leu Ser Pro Asp Val Gly His Leu Val Leu Thr Thr Leu Cys Pro 
    50                  55                  60                  


Ala Leu His Ala Leu Val Ala Asp Gly Leu Lys Pro Phe Arg Lys Asp 
65                  70                  75                  80  


Leu Ile Thr Gly Gln Arg Arg Ser Ser Pro Trp Ser Val Val Glu Ala 
                85                  90                  95      


Ser Val Lys Pro Gly Ser Ser Thr Arg Ser Leu Gly Thr Leu Tyr Ser 
            100                 105                 110         


Gln Val Ser Arg Leu Ala Pro Leu Ser Ser Ser Arg Ser Arg Phe His 
        115                 120                 125             


Ala Phe Ile Leu Gly Leu Leu Asn Thr Lys Gln Leu Glu Leu Trp Phe 
    130                 135                 140                 


Ser Ser Leu Gln Glu Asp Ala Gly Leu Leu Ser Leu Leu Tyr Leu Pro 
145                 150                 155                 160 


Thr Gly Phe Phe Ser Leu Ala Arg Gly Gly Cys Pro Ser Leu Ser Thr 
                165                 170                 175     


Glu Leu Leu Leu Leu Leu Gln Pro Leu Ser Val Leu Thr Phe His Leu 
            180                 185                 190         


Asp Leu Leu Phe Glu His His His His Leu Pro Leu Gly Pro Pro Gln 
        195                 200                 205             


Ala Pro Ala Pro Pro Gly Pro Pro Pro Ala Leu Gln Gln Thr Met Gln 
    210                 215                 220                 


Ala Met Leu His Phe Gly Gly Arg Leu Ala Gln Ser Leu Arg Gly Thr 
225                 230                 235                 240 


Ser Lys Glu Ala Ala Ser Asp Pro Ser Asp Ser Pro Asn Leu Pro Thr 
                245                 250                 255     


Pro Gly Ser Trp Trp Glu Gln Leu Thr Gln Ala Ser Arg Val Tyr Ala 
            260                 265                 270         


Ser Gly Gly Thr Glu Gly Phe Pro Leu Ser Arg Trp Ala Pro Gly Arg 
        275                 280                 285             


His Gly Thr Ala Ala Glu Glu Gly Ala Gln Glu Arg Pro Leu Pro Thr 
    290                 295                 300                 


Asp Glu Met Ala Pro Gly Arg Gly Leu Trp Leu Gly Arg Leu Phe Gly 
305                 310                 315                 320 


Val Pro Gly Gly Pro Ala Glu Asn Glu Asn Gly Ala Leu Lys Ser Arg 
                325                 330                 335     


Arg Pro Ser Ser Trp Leu Pro Pro Thr Val Ser Val Leu Ala Leu Val 
            340                 345                 350         


Lys Arg Gly Ala Pro Pro Glu Met Pro Ser Pro Gln Glu Leu Glu Ala 
        355                 360                 365             


Ser Ala Pro Arg Met Val Gln Thr His Arg Ala Val Arg Ala Leu Cys 
    370                 375                 380                 


Asp His Thr Ala Ala Arg Pro Asp Gln Leu Ser Phe Arg Arg Gly Glu 
385                 390                 395                 400 


Val Leu Arg Val Ile Thr Thr Val Asp Glu Asp Trp Leu Arg Cys Gly 
                405                 410                 415     


Arg Asp Gly Met Glu Gly Leu Val Pro Val Gly Tyr Thr Ser Leu Val 
            420                 425                 430         


Leu 
    


<210> 5131
<211> 527
<212> PRT
<213> Homo sapiens

<400> 5131
Met Ala Gln Thr Leu Gln Met Glu Ile Pro Asn Phe Gly Asn Ser Ile 
1               5                   10                  15      


Leu Glu Cys Leu Asn Glu Gln Arg Leu Gln Gly Leu Tyr Cys Asp Val 
            20                  25                  30          


Ser Val Val Val Lys Gly His Ala Phe Lys Ala His Arg Ala Val Leu 
        35                  40                  45              


Ala Ala Ser Ser Ser Tyr Phe Arg Asp Leu Phe Asn Asn Ser Arg Ser 
    50                  55                  60                  


Ala Val Val Glu Leu Pro Ala Ala Val Gln Pro Gln Ser Phe Gln Gln 
65                  70                  75                  80  


Ile Leu Ser Phe Cys Tyr Thr Gly Arg Leu Ser Met Asn Val Gly Asp 
                85                  90                  95      


Gln Phe Leu Leu Met Tyr Thr Ala Gly Phe Leu Gln Ile Gln Glu Ile 
            100                 105                 110         


Met Glu Lys Gly Thr Glu Phe Phe Leu Lys Val Ser Ser Pro Ser Cys 
        115                 120                 125             


Asp Ser Gln Gly Leu His Ala Glu Glu Ala Pro Ser Ser Glu Pro Gln 
    130                 135                 140                 


Ser Pro Val Ala Gln Thr Ser Gly Trp Pro Ala Cys Ser Thr Pro Leu 
145                 150                 155                 160 


Pro Leu Val Ser Arg Val Lys Thr Glu Gln Gln Glu Ser Asp Ser Val 
                165                 170                 175     


Gln Cys Met Pro Val Ala Lys Arg Leu Trp Asp Ser Gly Gln Lys Glu 
            180                 185                 190         


Ala Gly Gly Gly Gly Asn Gly Ser Arg Lys Met Ala Lys Phe Ser Thr 
        195                 200                 205             


Pro Asp Leu Ala Ala Asn Arg Pro His Gln Pro Pro Pro Pro Gln Gln 
    210                 215                 220                 


Ala Pro Val Val Ala Ala Ala Gln Pro Ala Val Ala Ala Gly Ala Gly 
225                 230                 235                 240 


Gln Pro Ala Gly Gly Val Ala Ala Ala Gly Gly Val Val Ser Gly Pro 
                245                 250                 255     


Ser Thr Ser Glu Arg Thr Ser Pro Gly Thr Ser Ser Ala Tyr Thr Ser 
            260                 265                 270         


Asp Ser Pro Gly Ser Tyr His Asn Glu Glu Asp Glu Glu Glu Asp Gly 
        275                 280                 285             


Gly Glu Glu Gly Met Asp Glu Gln Tyr Arg Gln Ile Cys Asn Met Tyr 
    290                 295                 300                 


Thr Met Tyr Ser Met Met Asn Val Gly Gln Thr Ala Glu Lys Val Glu 
305                 310                 315                 320 


Ala Leu Pro Glu Gln Val Ala Pro Glu Ser Arg Asn Arg Ile Arg Val 
                325                 330                 335     


Arg Gln Asp Leu Ala Ser Leu Pro Ala Glu Leu Ile Asn Gln Ile Gly 
            340                 345                 350         


Asn Arg Cys His Pro Lys Leu Tyr Asp Glu Gly Asp Pro Ser Glu Lys 
        355                 360                 365             


Leu Glu Leu Val Thr Gly Thr Asn Val Tyr Ile Thr Arg Ala Gln Leu 
    370                 375                 380                 


Met Asn Cys His Val Ser Ala Gly Thr Arg His Lys Val Leu Leu Arg 
385                 390                 395                 400 


Arg Leu Leu Ala Ser Phe Phe Asp Arg Asn Thr Leu Ala Asn Ser Cys 
                405                 410                 415     


Gly Thr Gly Ile Arg Ser Ser Thr Asn Asp Pro Arg Arg Lys Pro Leu 
            420                 425                 430         


Asp Ser Arg Val Leu His Ala Val Lys Tyr Tyr Cys Gln Asn Phe Ala 
        435                 440                 445             


Pro Asn Phe Lys Glu Ser Glu Met Asn Ala Ile Ala Ala Asp Met Cys 
    450                 455                 460                 


Thr Asn Ala Arg Arg Val Val Arg Lys Ser Trp Met Pro Lys Val Lys 
465                 470                 475                 480 


Val Leu Lys Ala Glu Asp Asp Ala Tyr Thr Thr Phe Ile Ser Glu Thr 
                485                 490                 495     


Gly Lys Ile Glu Pro Asp Met Met Gly Val Glu His Gly Phe Glu Thr 
            500                 505                 510         


Ala Ser His Glu Gly Glu Ala Gly Pro Ser Ala Glu Ala Leu Gln 
        515                 520                 525         


<210> 5132
<211> 223
<212> PRT
<213> Homo sapiens

<400> 5132
Met Glu Val Gln Lys Glu Ala Gln Arg Ile Met Thr Leu Ser Val Trp 
1               5                   10                  15      


Lys Met Tyr His Ser Arg Met Gln Arg Gly Gly Leu Arg Leu His Arg 
            20                  25                  30          


Ser Leu Gln Leu Ser Leu Val Met Arg Ser Ala Arg Glu Leu Tyr Leu 
        35                  40                  45              


Ser Ala Lys Val Glu Ala Leu Glu Pro Glu Val Ser Leu Pro Ala Ala 
    50                  55                  60                  


Leu Pro Ser Asp Pro Arg Leu His Pro Pro Arg Glu Ala Glu Ser Thr 
65                  70                  75                  80  


Ala Glu Thr Ala Thr Pro Asp Gly Glu His Pro Phe Pro Glu Pro Met 
                85                  90                  95      


Asp Thr Gln Glu Ala Pro Thr Ala Glu Glu Thr Ser Ala Cys Cys Ala 
            100                 105                 110         


Pro Arg Pro Ala Lys Val Ser Arg Lys Arg Arg Ser Ser Ser Leu Ser 
        115                 120                 125             


Asp Gly Gly Asp Ala Gly Leu Val Pro Ser Lys Lys Ala Arg Leu Glu 
    130                 135                 140                 


Glu Lys Glu Glu Glu Glu Gly Ala Ser Ser Glu Val Ala Asp Arg Leu 
145                 150                 155                 160 


Gln Pro Pro Pro Ala Gln Ala Glu Gly Ala Phe Pro Asn Leu Ala Arg 
                165                 170                 175     


Val Leu Gln Arg Arg Phe Ser Gly Leu Leu Asn Cys Ser Pro Ala Ala 
            180                 185                 190         


Pro Pro Thr Ala Pro Pro Ala Cys Glu Ala Lys Pro Ala Cys Arg Pro 
        195                 200                 205             


Ala Asp Ser Met Leu Asn Val Leu Val Arg Ala Val Val Ala Phe 
    210                 215                 220             


<210> 5133
<211> 499
<212> PRT
<213> Homo sapiens

<400> 5133
Met Arg Val Leu Val Pro Pro Ala Glu Arg Ser Gln Asp Thr Arg Val 
1               5                   10                  15      


Gly Ala Pro Ala Trp Arg Glu Ala Ala Gln Ala Met Ala Arg Thr Ala 
            20                  25                  30          


His Ile Leu Thr Asp Arg Cys Gly Gln Glu Ala Val Thr Met Trp Gln 
        35                  40                  45              


Pro Lys Asp Ser Val Leu Asp Pro Asn Val Ala His His Leu Gly Arg 
    50                  55                  60                  


Ala Ala Tyr Ile Gln Pro Trp Arg Phe Arg Val Glu Met Ile Lys Gly 
65                  70                  75                  80  


Gly Gly Thr Leu Glu Lys Pro Pro Pro Gly Glu Gly Val Thr Leu Trp 
                85                  90                  95      


Lys Gly Lys Met Lys Pro Pro Ala Trp Tyr Ala Arg Leu Pro Leu Pro 
            100                 105                 110         


Leu His Arg Lys Ala Arg Ala Leu Gln Thr Thr Glu Val Val His Ala 
        115                 120                 125             


His Ala Arg Gly Ala Arg Leu Thr Ala Ala Arg Leu Gly Arg Ala Gln 
    130                 135                 140                 


His Gln Ile Asn Gly Arg Val Arg Gln Leu Leu Arg Gln Arg Glu Val 
145                 150                 155                 160 


Thr Asp His Arg Leu Ser Glu Val Arg Lys Gly Leu Leu Ile Asn Gln 
                165                 170                 175     


Gln Ser Val Lys Leu Arg Gly Tyr Arg Pro Lys Ser Glu Lys Val Pro 
            180                 185                 190         


Asp Lys Ala Asp Ser Met Leu Thr Trp Glu Lys Glu Glu Leu Lys Ser 
        195                 200                 205             


Met Lys Arg Lys Met Glu Arg Asp Met Glu Lys Ser Glu Val Leu Leu 
    210                 215                 220                 


Lys Thr Leu Ala Ser Cys Arg Asp Thr Leu Asn Phe Cys Phe Lys Glu 
225                 230                 235                 240 


Arg Leu Gln Ala Val Asp Leu Met Asn Gln Pro Leu Asp Lys Val Leu 
                245                 250                 255     


Glu Gln Ala Arg Arg His Ser Trp Val Asn Leu Ser Arg Ala Pro Thr 
            260                 265                 270         


Pro Arg Thr Gln Gly Gln Lys Thr Pro Pro Pro Asp Pro Val Gly Thr 
        275                 280                 285             


Tyr Asn Pro Ala Cys Ala Leu Ala Leu Asn Glu Ala Lys Arg Leu Leu 
    290                 295                 300                 


Val Glu Ser Lys Asp Thr Leu Val Glu Met Ala Lys Asn Glu Val Asp 
305                 310                 315                 320 


Val Arg Glu Gln Gln Leu Gln Ile Ser Asp Arg Val Cys Ala Ser Leu 
                325                 330                 335     


Ala Gln Lys Ala Ser Glu Thr Leu Glu Leu Lys Glu Arg Leu Asn Met 
            340                 345                 350         


Thr Leu Gly Leu Met Arg Gly Thr Ile Leu Arg Cys Thr Lys Tyr Asn 
        355                 360                 365             


Gln Glu Leu Tyr Thr Thr His Gly Leu Ile Lys Gly Pro Leu Ser Lys 
    370                 375                 380                 


Val His Leu Glu Thr Ala Glu Lys Leu Asp Arg Pro Leu Val Arg Met 
385                 390                 395                 400 


Tyr Gln Arg His Val Gly Thr Gln Leu Pro Glu Ala Ala Arg Leu Ala 
                405                 410                 415     


Gln Gly Thr Asp Lys Leu Gln Cys His Ile Thr Tyr Leu Glu Lys Asn 
            420                 425                 430         


Leu Asp Glu Leu Leu Ala Thr His Lys Asn Leu Ser Trp Gly Leu Asn 
        435                 440                 445             


Cys Lys Asn Ile Gly His Glu Val Asp Gly Asn Val Val Arg Leu Arg 
    450                 455                 460                 


Leu Arg Gln Arg Gln Pro His Val Cys Tyr Glu Gln Ala Gln Arg Leu 
465                 470                 475                 480 


Val Lys Asp Trp Asp Pro Arg Thr Pro Pro Pro Arg Ser Lys Ser Ser 
                485                 490                 495     


Ala Asp Pro 
            


<210> 5134
<211> 608
<212> PRT
<213> Homo sapiens

<400> 5134
Met Glu Met Glu Ser Ala Ala Ala Ser Thr Arg Phe His Gln Pro His 
1               5                   10                  15      


Met Glu Arg Lys Met Ser Ala Met Ala Cys Glu Ile Phe Asn Glu Leu 
            20                  25                  30          


Arg Leu Glu Gly Lys Leu Cys Asp Val Val Ile Lys Val Asn Gly Phe 
        35                  40                  45              


Glu Phe Ser Ala His Lys Asn Ile Leu Cys Ser Cys Ser Ser Tyr Phe 
    50                  55                  60                  


Arg Ala Leu Phe Thr Ser Gly Trp Asn Asn Thr Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Asn Ile Pro Gly Ile Ser Pro Asp Met Met Lys Leu Ile Ile Glu Tyr 
                85                  90                  95      


Ala Tyr Thr Arg Thr Val Pro Ile Thr Pro Asp Asn Val Glu Lys Leu 
            100                 105                 110         


Leu Ala Ala Ala Asp Gln Phe Asn Ile Met Gly Ile Val Arg Gly Cys 
        115                 120                 125             


Cys Glu Phe Leu Lys Ser Glu Leu Cys Leu Asp Asn Cys Ile Gly Ile 
    130                 135                 140                 


Cys Lys Phe Thr Asp Tyr Tyr Tyr Cys Pro Glu Leu Arg Gln Lys Ala 
145                 150                 155                 160 


Tyr Met Phe Ile Leu His Asn Phe Glu Glu Met Val Lys Val Ser Ala 
                165                 170                 175     


Glu Phe Leu Glu Leu Ser Val Thr Glu Leu Lys Asp Ile Ile Glu Lys 
            180                 185                 190         


Asp Glu Leu Asn Val Lys Gln Glu Asp Ala Val Phe Glu Ala Ile Leu 
        195                 200                 205             


Lys Trp Ile Ser His Asp Pro Gln Asn Arg Lys Gln His Ile Ser Ile 
    210                 215                 220                 


Leu Leu Pro Lys Val Arg Leu Ala Leu Met His Ala Glu Tyr Phe Met 
225                 230                 235                 240 


Asn Asn Val Lys Met Asn Asp Tyr Val Lys Asp Ser Glu Glu Cys Lys 
                245                 250                 255     


Pro Val Ile Ile Asn Ala Leu Lys Ala Met Tyr Asp Leu Asn Met Asn 
            260                 265                 270         


Gly Pro Ser Asn Ser Asp Phe Thr Asn Pro Leu Thr Arg Pro Arg Leu 
        275                 280                 285             


Pro Tyr Ala Ile Leu Phe Ala Ile Gly Gly Trp Ser Gly Gly Ser Pro 
    290                 295                 300                 


Thr Asn Ala Ile Glu Ala Tyr Asp Ala Arg Ala Asp Arg Trp Val Asn 
305                 310                 315                 320 


Val Thr Cys Glu Glu Glu Ser Pro Arg Ala Tyr His Gly Ala Ala Tyr 
                325                 330                 335     


Leu Lys Gly Tyr Val Tyr Ile Ile Gly Gly Phe Asp Ser Val Asp Tyr 
            340                 345                 350         


Phe Asn Ser Val Lys Arg Phe Asp Pro Val Lys Lys Thr Trp His Gln 
        355                 360                 365             


Val Ala Pro Met His Ser Arg Arg Cys Tyr Val Ser Val Thr Val Leu 
    370                 375                 380                 


Gly Asn Phe Ile Tyr Ala Met Gly Gly Phe Asp Gly Tyr Val Arg Leu 
385                 390                 395                 400 


Asn Thr Ala Glu Arg Tyr Glu Pro Glu Thr Asn Gln Trp Thr Leu Ile 
                405                 410                 415     


Ala Pro Met His Glu Gln Arg Ser Asp Ala Ser Ala Thr Thr Leu Tyr 
            420                 425                 430         


Gly Lys Val Tyr Ile Cys Gly Gly Phe Asn Gly Asn Glu Cys Leu Phe 
        435                 440                 445             


Thr Ala Glu Val Tyr Asn Thr Glu Ser Asn Gln Trp Thr Val Ile Ala 
    450                 455                 460                 


Pro Met Arg Ser Arg Arg Ser Gly Ile Gly Val Ile Ala Tyr Gly Glu 
465                 470                 475                 480 


His Val Tyr Ala Val Gly Gly Phe Asp Gly Ala Asn Arg Leu Arg Ser 
                485                 490                 495     


Ala Glu Ala Tyr Ser Pro Val Ala Asn Thr Trp Arg Thr Ile Pro Thr 
            500                 505                 510         


Met Phe Asn Pro Arg Ser Asn Phe Gly Ile Glu Val Val Asp Asp Leu 
        515                 520                 525             


Leu Phe Val Val Gly Gly Phe Asn Gly Phe Thr Thr Thr Phe Asn Val 
    530                 535                 540                 


Glu Cys Tyr Asp Glu Lys Thr Asp Glu Trp Tyr Asp Ala His Asp Met 
545                 550                 555                 560 


Ser Ile Tyr Arg Ser Ala Leu Ser Cys Cys Val Val Pro Gly Leu Ala 
                565                 570                 575     


Asn Val Glu Glu Tyr Ala Ala Arg Arg Asp Asn Phe Pro Gly Leu Ala 
            580                 585                 590         


Leu Arg Asp Glu Val Lys Tyr Ser Ala Ser Thr Ser Thr Leu Pro Val 
        595                 600                 605             


<210> 5135
<211> 313
<212> PRT
<213> Homo sapiens

<400> 5135
Met Ala Ala Leu Thr Asp Leu Ser Phe Met Tyr Arg Trp Phe Lys Asn 
1               5                   10                  15      


Cys Asn Leu Val Gly Asn Leu Ser Glu Lys Tyr Val Phe Ile Thr Gly 
            20                  25                  30          


Cys Asp Ser Gly Phe Gly Asn Leu Leu Ala Lys Gln Leu Val Asp Arg 
        35                  40                  45              


Gly Met Gln Val Leu Ala Ala Cys Phe Thr Glu Glu Gly Ser Gln Lys 
    50                  55                  60                  


Leu Gln Arg Asp Thr Ser Tyr Arg Leu Gln Thr Thr Leu Leu Asp Val 
65                  70                  75                  80  


Thr Lys Ser Glu Ser Ile Lys Ala Ala Ala Gln Trp Val Arg Asp Lys 
                85                  90                  95      


Val Gly Glu Gln Gly Leu Trp Ala Leu Val Asn Asn Ala Gly Val Gly 
            100                 105                 110         


Leu Pro Ser Gly Pro Asn Glu Trp Leu Thr Lys Asp Asp Phe Val Lys 
        115                 120                 125             


Val Ile Asn Val Asn Leu Val Gly Leu Ile Glu Val Thr Leu His Met 
    130                 135                 140                 


Leu Pro Met Val Lys Arg Ala Arg Gly Arg Val Val Asn Met Ser Ser 
145                 150                 155                 160 


Ser Gly Gly Arg Val Ala Val Ile Gly Gly Gly Tyr Cys Val Ser Lys 
                165                 170                 175     


Phe Gly Val Glu Ala Phe Ser Asp Ser Ile Arg Arg Glu Leu Tyr Tyr 
            180                 185                 190         


Phe Gly Val Lys Val Cys Ile Ile Glu Pro Gly Asn Tyr Arg Thr Ala 
        195                 200                 205             


Ile Leu Gly Lys Glu Asn Leu Glu Ser Arg Met Arg Lys Leu Trp Glu 
    210                 215                 220                 


Arg Leu Pro Gln Glu Thr Arg Asp Ser Tyr Gly Glu Asp Tyr Phe Arg 
225                 230                 235                 240 


Ile Tyr Thr Asp Lys Leu Lys Asn Ile Met Gln Val Ala Glu Pro Arg 
                245                 250                 255     


Val Arg Asp Val Ile Asn Ser Met Glu His Ala Ile Val Ser Arg Ser 
            260                 265                 270         


Pro Arg Ile Arg Tyr Asn Pro Gly Leu Asp Ala Lys Leu Leu Tyr Ile 
        275                 280                 285             


Pro Leu Ala Lys Leu Pro Thr Pro Val Thr Asp Phe Ile Leu Ser Arg 
    290                 295                 300                 


Tyr Leu Pro Arg Pro Ala Asp Ser Val 
305                 310             


<210> 5136
<211> 486
<212> PRT
<213> Homo sapiens

<400> 5136
Met Thr Cys Gly Ser Tyr Cys Gly Gly Arg Ala Phe Ser Cys Ile Ser 
1               5                   10                  15      


Ala Cys Gly Pro Arg Pro Gly Arg Cys Cys Ile Thr Ala Ala Pro Tyr 
            20                  25                  30          


Arg Gly Ile Ser Cys Tyr Arg Gly Leu Thr Gly Gly Phe Gly Ser His 
        35                  40                  45              


Ser Val Cys Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe Gly 
    50                  55                  60                  


Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr Thr 
65                  70                  75                  80  


Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp 
                85                  90                  95      


Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys Ser 
            100                 105                 110         


Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu Glu 
        115                 120                 125             


Gln Gln Asn Lys Leu Leu Glu Thr Lys Leu Gln Phe Tyr Gln Asn Arg 
    130                 135                 140                 


Glu Cys Cys Gln Ser Asn Leu Glu Pro Leu Phe Glu Gly Tyr Ile Glu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg Leu 
                165                 170                 175     


Ala Ser Glu Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys Lys 
            180                 185                 190         


Lys Tyr Glu Glu Glu Val Ser Leu Arg Ala Thr Ala Glu Asn Glu Phe 
        195                 200                 205             


Val Ala Leu Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp 
    210                 215                 220                 


Leu Glu Ala Asn Val Glu Ala Leu Ile Gln Glu Ile Asp Phe Leu Arg 
225                 230                 235                 240 


Arg Leu Tyr Glu Glu Glu Ile Arg Val Leu Gln Ser His Ile Ser Asp 
                245                 250                 255     


Thr Ser Val Val Val Lys Leu Asp Asn Ser Arg Asp Leu Asn Met Asp 
            260                 265                 270         


Cys Ile Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Val Thr Arg 
        275                 280                 285             


Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met 
    290                 295                 300                 


Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu 
305                 310                 315                 320 


Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Val 
                325                 330                 335     


Glu Asn Ala Lys Cys Gln Asn Ser Lys Leu Glu Ala Ala Val Ala Gln 
            340                 345                 350         


Ser Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu 
        355                 360                 365             


Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys 
    370                 375                 380                 


Leu Ile Arg Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp 
385                 390                 395                 400 


Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu Gln Arg 
                405                 410                 415     


Leu Cys Glu Gly Val Gly Ser Val Asn Val Cys Val Ser Ser Ser Arg 
            420                 425                 430         


Gly Gly Val Val Cys Gly Asp Leu Cys Ala Ser Thr Thr Ala Pro Val 
        435                 440                 445             


Val Ser Thr Arg Val Ser Ser Val Pro Ser Asn Ser Asn Val Val Val 
    450                 455                 460                 


Gly Thr Thr Asn Ala Cys Ala Pro Ser Ala Arg Val Gly Val Cys Gly 
465                 470                 475                 480 


Gly Ser Cys Lys Arg Cys 
                485     


<210> 5137
<211> 312
<212> PRT
<213> Homo sapiens

<400> 5137
Met Ala Glu Leu Thr Ala Leu Glu Ser Leu Ile Glu Met Gly Phe Pro 
1               5                   10                  15      


Arg Gly Arg Ala Glu Lys Ala Leu Ala Leu Thr Gly Asn Gln Gly Ile 
            20                  25                  30          


Glu Ala Ala Met Asp Trp Leu Met Glu His Glu Asp Asp Pro Asp Val 
        35                  40                  45              


Asp Glu Pro Leu Glu Thr Pro Leu Gly His Ile Leu Gly Arg Glu Pro 
    50                  55                  60                  


Thr Ser Ser Glu Gln Gly Gly Leu Glu Gly Ser Gly Ser Ala Ala Gly 
65                  70                  75                  80  


Glu Gly Lys Pro Ala Leu Ser Glu Glu Glu Arg Gln Glu Gln Thr Lys 
                85                  90                  95      


Arg Met Leu Glu Leu Val Ala Gln Lys Gln Arg Glu Arg Glu Glu Arg 
            100                 105                 110         


Glu Glu Arg Glu Ala Leu Glu Arg Glu Arg Gln Arg Arg Arg Gln Gly 
        115                 120                 125             


Gln Glu Leu Ser Ala Ala Arg Gln Arg Leu Gln Glu Asp Glu Met Arg 
    130                 135                 140                 


Arg Ala Ala Glu Glu Arg Arg Arg Glu Lys Ala Glu Glu Leu Ala Ala 
145                 150                 155                 160 


Arg Gln Arg Val Arg Glu Lys Ile Glu Arg Asp Lys Ala Glu Arg Ala 
                165                 170                 175     


Lys Lys Tyr Gly Gly Ser Val Gly Ser Gln Pro Pro Pro Val Ala Pro 
            180                 185                 190         


Glu Pro Gly Pro Val Pro Ser Ser Pro Ser Gln Glu Pro Pro Thr Lys 
        195                 200                 205             


Arg Glu Tyr Asp Gln Cys Arg Ile Gln Val Arg Leu Pro Asp Gly Thr 
    210                 215                 220                 


Ser Leu Thr Gln Thr Phe Arg Ala Arg Glu Gln Leu Ala Ala Val Arg 
225                 230                 235                 240 


Leu Tyr Val Glu Leu His Arg Gly Glu Glu Leu Gly Gly Gly Gln Asp 
                245                 250                 255     


Pro Val Gln Leu Leu Ser Gly Phe Pro Arg Arg Ala Phe Ser Glu Ala 
            260                 265                 270         


Asp Met Glu Arg Pro Leu Gln Glu Leu Gly Met Ala Ala Arg Leu Glu 
        275                 280                 285             


Thr Arg Thr Arg Asn Trp Gly Ser Arg Glu Ala Cys Leu Gly Lys Gly 
    290                 295                 300                 


Gly Met Gln Arg Glu Gly Ala Leu 
305                 310         


<210> 5138
<211> 134
<212> PRT
<213> Homo sapiens

<400> 5138
Met Pro Ala Asp Leu Ser Gly Thr Trp Thr Leu Leu Ser Ser Asp Asn 
1               5                   10                  15      


Phe Glu Gly Tyr Met Leu Ala Leu Gly Ile Asp Phe Ala Thr Arg Lys 
            20                  25                  30          


Ile Ala Lys Leu Leu Lys Pro Gln Lys Val Ile Glu Gln Asn Gly Asp 
        35                  40                  45              


Ser Phe Thr Ile His Thr Asn Ser Ser Leu Arg Asn Tyr Phe Val Lys 
    50                  55                  60                  


Phe Lys Val Gly Glu Glu Phe Asp Glu Asp Asn Arg Gly Leu Asp Asn 
65                  70                  75                  80  


Arg Lys Cys Lys Ser Leu Val Ile Trp Asp Asn Asp Arg Leu Thr Cys 
                85                  90                  95      


Ile Gln Lys Gly Glu Lys Lys Asn Arg Gly Trp Thr His Trp Ile Glu 
            100                 105                 110         


Gly Asp Lys Leu His Leu Glu Met Phe Cys Glu Gly Gln Val Cys Lys 
        115                 120                 125             


Gln Thr Phe Gln Arg Ala 
    130                 


<210> 5139
<211> 460
<212> PRT
<213> Homo sapiens

<400> 5139
Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ala Glu Met 
                85                  90                  95      


Glu Leu Val Gln His Ile Gly Ile Pro Ala Ser Lys Ile Ile Cys Ala 
            100                 105                 110         


Asn Pro Cys Lys Gln Ile Ala Gln Ile Lys Tyr Ala Ala Lys His Gly 
        115                 120                 125             


Ile Gln Leu Leu Ser Phe Asp Asn Glu Met Glu Leu Ala Lys Val Val 
    130                 135                 140                 


Lys Ser His Pro Ser Ala Lys Met Val Leu Cys Ile Ala Thr Asp Asp 
145                 150                 155                 160 


Ser His Ser Leu Ser Cys Leu Ser Leu Lys Phe Gly Val Ser Leu Lys 
                165                 170                 175     


Ser Cys Arg His Leu Leu Glu Asn Ala Lys Lys His His Val Glu Val 
            180                 185                 190         


Val Gly Val Ser Phe His Ile Gly Ser Gly Cys Pro Asp Pro Gln Ala 
        195                 200                 205             


Tyr Ala Gln Ser Ile Ala Asp Ala Arg Leu Val Phe Glu Met Gly Thr 
    210                 215                 220                 


Glu Leu Gly His Lys Met His Val Leu Asp Leu Gly Gly Gly Phe Pro 
225                 230                 235                 240 


Gly Thr Glu Gly Ala Lys Val Arg Phe Glu Glu Ile Ala Ser Val Ile 
                245                 250                 255     


Asn Ser Ala Leu Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val Asp Ile 
            260                 265                 270         


Phe Ala Glu Leu Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr Val Ala 
        275                 280                 285             


Val Ser Ile Ile Ala Lys Lys Glu Val Leu Leu Asp Gln Pro Gly Arg 
    290                 295                 300                 


Glu Glu Glu Asn Gly Ser Thr Ser Lys Thr Ile Val Tyr His Leu Asp 
305                 310                 315                 320 


Glu Gly Val Tyr Gly Ile Phe Asn Ser Val Leu Phe Asp Asn Ile Cys 
                325                 330                 335     


Pro Thr Pro Ile Leu Gln Lys Lys Pro Ser Thr Glu Gln Pro Leu Tyr 
            340                 345                 350         


Ser Ser Ser Leu Trp Gly Pro Ala Val Asp Gly Cys Asp Cys Val Ala 
        355                 360                 365             


Glu Gly Leu Trp Leu Pro Gln Leu His Val Gly Asp Trp Leu Val Phe 
    370                 375                 380                 


Asp Asn Met Gly Ala Tyr Thr Val Gly Met Gly Ser Pro Phe Trp Gly 
385                 390                 395                 400 


Thr Gln Ala Cys His Ile Thr Tyr Ala Met Ser Arg Val Ala Trp Glu 
                405                 410                 415     


Ala Leu Arg Arg Gln Leu Met Ala Ala Glu Gln Glu Asp Asp Val Glu 
            420                 425                 430         


Gly Val Cys Lys Pro Leu Ser Cys Gly Trp Glu Ile Thr Asp Thr Leu 
        435                 440                 445             


Cys Val Gly Pro Val Phe Thr Pro Ala Ser Ile Met 
    450                 455                 460 


<210> 5140
<211> 402
<212> PRT
<213> Homo sapiens

<400> 5140
Gly Gly Pro Arg Gly Ser Gly Ser Ala Ala Glu Thr Met Pro Glu Ile 
1               5                   10                  15      


Arg Val Thr Pro Leu Gly Ala Gly Gln Asp Val Gly Arg Ser Cys Ile 
            20                  25                  30          


Leu Val Ser Ile Ala Gly Lys Asn Val Met Leu Asp Cys Gly Met His 
        35                  40                  45              


Met Gly Phe Asn Asp Asp Arg Arg Phe Pro Asp Phe Ser Tyr Ile Thr 
    50                  55                  60                  


Gln Asn Gly Arg Leu Thr Asp Phe Leu Asp Cys Val Ile Ile Ser His 
65                  70                  75                  80  


Phe His Leu Asp His Cys Gly Ala Leu Pro Tyr Phe Ser Glu Met Val 
                85                  90                  95      


Gly Tyr Asp Gly Pro Ile Tyr Met Thr His Pro Thr Gln Ala Ile Cys 
            100                 105                 110         


Pro Ile Leu Leu Glu Asp Tyr Arg Lys Ile Ala Val Asp Lys Lys Gly 
        115                 120                 125             


Glu Ala Asn Phe Phe Thr Ser Gln Met Ile Lys Asp Cys Met Asn Leu 
    130                 135                 140                 


Leu Glu Thr Phe Trp Glu Arg Met Asn Leu Lys Val Pro Ile Tyr Phe 
145                 150                 155                 160 


Ser Thr Gly Leu Thr Glu Lys Ala Asn His Tyr Tyr Lys Leu Phe Ile 
                165                 170                 175     


Pro Trp Thr Asn Gln Lys Ile Arg Lys Thr Phe Val Gln Arg Asn Met 
            180                 185                 190         


Phe Glu Phe Lys His Ile Lys Ala Phe Asp Arg Ala Phe Ala Asp Asn 
        195                 200                 205             


Pro Gly Pro Met Val Val Phe Ala Thr Pro Gly Met Leu His Ala Gly 
    210                 215                 220                 


Gln Ser Leu Gln Ile Phe Arg Lys Trp Ala Gly Asn Glu Lys Asn Met 
225                 230                 235                 240 


Val Ile Met Pro Gly Tyr Cys Val Gln Gly Thr Val Gly His Lys Ile 
                245                 250                 255     


Leu Ser Gly Gln Arg Lys Leu Glu Met Glu Gly Arg Gln Val Leu Glu 
            260                 265                 270         


Val Lys Met Gln Val Glu Tyr Met Ser Phe Ser Ala His Ala Asp Ala 
        275                 280                 285             


Lys Gly Ile Met Gln Leu Val Ser Ser Glu Gln Ala Leu Lys Glu Leu 
    290                 295                 300                 


Gly Leu Ala Glu His Gln Leu Arg Phe Thr Cys Arg Val His Leu His 
305                 310                 315                 320 


Asp Thr Arg Lys Glu Gln Glu Thr Ala Leu Arg Val Tyr Ser His Leu 
                325                 330                 335     


Lys Ser Val Leu Lys Asp His Cys Val Gln His Leu Pro Asp Gly Ser 
            340                 345                 350         


Val Thr Val Glu Ser Val Leu Leu Gln Ala Ala Ala Pro Ser Glu Asp 
        355                 360                 365             


Pro Gly Thr Lys Val Leu Leu Val Ser Trp Thr Tyr Gln Asp Glu Glu 
    370                 375                 380                 


Leu Gly Ser Phe Leu Thr Ser Leu Leu Lys Lys Gly Leu Pro Gln Ala 
385                 390                 395                 400 


Pro Ser 
        


<210> 5141
<211> 620
<212> PRT
<213> Homo sapiens

<400> 5141
Met Glu Lys Ala Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys 
1               5                   10                  15      


His Leu Lys Thr Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser 
            20                  25                  30          


Glu Ser His Leu Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr 
        35                  40                  45              


Glu Leu Glu Ala Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val 
    50                  55                  60                  


Glu Leu Leu Leu Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe 
65                  70                  75                  80  


Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ile Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Glu His Leu Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn 
        115                 120                 125             


Leu Ser Ser Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn 
    130                 135                 140                 


Thr Asn Leu Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn 
                165                 170                 175     


Arg Phe Ser Gln Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln 
            180                 185                 190         


Ile His Lys Arg Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys 
        195                 200                 205             


Ser Leu Glu Thr Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn 
    210                 215                 220                 


Lys Asn Glu Ala Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val 
225                 230                 235                 240 


Ala Leu Lys Lys Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe 
                245                 250                 255     


Thr Gly Ala Ile Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala 
            260                 265                 270         


Lys Leu Ser Glu Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr 
        275                 280                 285             


Glu Lys Ile Val Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr 
    290                 295                 300                 


Met Lys Lys Gln Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu 
305                 310                 315                 320 


Asp His Gly Lys Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser 
                325                 330                 335     


Ile Glu Tyr Glu Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys 
            340                 345                 350         


Thr Thr Leu Ala Ala Leu Lys Asp Glu Val Val Ser Val Glu Asn Glu 
        355                 360                 365             


Leu Ser Glu Leu Gln Glu Val Glu Lys Lys Gln Lys Thr Leu Ile Glu 
    370                 375                 380                 


Met Tyr Lys Thr Gln Val Gln Lys Leu Gln Glu Ala Ala Glu Ile Val 
385                 390                 395                 400 


Lys Ser Arg Cys Glu Asn Leu Leu His Lys Asn Asn Gln Ile Thr Lys 
                405                 410                 415     


Thr Lys Asn Lys Asn Val Glu Lys Met Arg Gly Gln Met Glu Ser His 
            420                 425                 430         


Leu Lys Glu Leu Glu Arg Val Cys Asp Ser Leu Thr Ala Ala Glu Arg 
        435                 440                 445             


Arg Leu His Glu Cys Gln Glu Ser Leu Gln Cys Cys Lys Gly Lys Cys 
    450                 455                 460                 


Ala Asp Gln Glu His Thr Ile Arg Glu Leu Gln Gly Gln Ile Leu Lys 
465                 470                 475                 480 


Gln Trp Glu Glu Tyr Ser Val Leu Ala Trp Val Asp Gly Asn His Asn 
                485                 490                 495     


Leu Leu Thr Lys Leu Ser Leu Glu Glu Glu Asn Cys Leu Ile Gln Leu 
            500                 505                 510         


Lys Cys Glu Asn Leu Gln Gln Lys Leu Glu Gln Met Asp Ala Glu Asn 
        515                 520                 525             


Lys Glu Leu Glu Lys Lys Leu Ala Asn Gln Glu Glu Cys Leu Lys His 
    530                 535                 540                 


Ser Asn Leu Lys Phe Lys Glu Lys Ser Ala Glu Tyr Thr Ala Leu Ala 
545                 550                 555                 560 


Arg Gln Leu Glu Ala Ala Leu Glu Glu Gly Arg Gln Lys Val Ala Glu 
                565                 570                 575     


Glu Ile Glu Lys Met Ser Ser Arg Glu Ser Ala Leu Gln Ile Lys Ile 
            580                 585                 590         


Leu Asp Leu Glu Thr Glu Leu Arg Lys Lys Asn Glu Glu Gln Asn Gln 
        595                 600                 605             


Leu Val Cys Lys Met Asn Ser Asp Pro Glu Thr Pro 
    610                 615                 620 


<210> 5142
<211> 154
<212> PRT
<213> Homo sapiens

<400> 5142
Met Ser Lys Asn Thr Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg His 
        35                  40                  45              


Ser Ile Thr Gly Asn Met Thr Ala Ala Leu Gln Ala Ala Leu Lys Asn 
    50                  55                  60                  


Pro Pro Ile Asn Thr Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser 
65                  70                  75                  80  


Ile Val Leu Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys 
                85                  90                  95      


Ala Val Gln Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr 
            100                 105                 110         


Ile Tyr Lys Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu 
        115                 120                 125             


Leu Gln Trp His Glu Lys Ala Leu Ala Ala Gly Gly Val Gly Ser Ile 
    130                 135                 140                 


Val Arg Val Leu Thr Ala Arg Lys Thr Val 
145                 150                 


<210> 5143
<211> 981
<212> PRT
<213> Homo sapiens

<400> 5143
Met Ser Glu Gln Glu Arg Ile Gln Glu Cys Leu Arg Lys Glu Ile Arg 
1               5                   10                  15      


Ser Leu Leu Ile Ser Thr Lys Asp Gly Leu Ser Pro Gln Glu Leu Glu 
            20                  25                  30          


Lys Glu Tyr Leu Leu Met Val Gly Asn His Leu Pro Leu Arg Ile Leu 
        35                  40                  45              


Gly Tyr Arg Ser Thr Met Glu Leu Val Leu Asp Met Pro Asp Val Val 
    50                  55                  60                  


Arg Val Cys Pro Gly Ala Gly Gly Thr Val Ile Leu Lys Ala Ile Pro 
65                  70                  75                  80  


Asp Glu Ser Thr Lys Gly Ile Ala Ser Leu Val Ala Lys Gln Arg Ser 
                85                  90                  95      


Ser His Lys Leu Arg Asn Ser Met His Lys Gly Arg Pro Ser Ile Tyr 
            100                 105                 110         


Ser Gly Pro Arg Ser His Arg Arg Val Pro Tyr Arg Gly Arg Val Ala 
        115                 120                 125             


Pro Ile Leu Pro Ala Val Val Lys Ser Glu Leu Lys Asp Leu Leu Ala 
    130                 135                 140                 


Leu Ser Pro Val Leu Leu Ser Asp Phe Glu Lys Ala Phe Ala Lys Arg 
145                 150                 155                 160 


Phe Gly Arg Ser Phe Gln Tyr Met Gln Tyr Gly Phe Leu Ser Met Phe 
                165                 170                 175     


Glu Val Leu Asn Ala Ala Ser Asp Val Ile Ser Val Glu Gln Thr Arg 
            180                 185                 190         


Ala Gly Ser Leu Leu Met Leu Lys Lys Ser Val Thr Glu Glu Lys Pro 
        195                 200                 205             


Arg Gly Cys Pro Ala Gly Lys Ile Phe Thr Gln Pro Phe Arg Met Lys 
    210                 215                 220                 


Gln Gly Ser Tyr Ser Thr Gly Phe Pro Val Ala Lys Pro Cys Phe Ser 
225                 230                 235                 240 


Gln Pro Thr Ser Asn Met Glu Pro Pro Lys Gln Ile Met Ser Met Glu 
                245                 250                 255     


Lys Thr Ser Lys Leu Asn Val Val Glu Thr Ser Arg Leu Asn His Thr 
            260                 265                 270         


Glu Lys Leu Asn Gln Leu Glu Asn Thr Phe Lys Ser Val Ile Ala Gln 
        275                 280                 285             


Ile Gly Pro Gly Gly Thr Ile Ser Ser Glu Leu Lys His Lys Ile Lys 
    290                 295                 300                 


Phe Val Val Ser Lys Phe Pro Glu Gly Leu Phe Ile Ser Lys Leu Leu 
305                 310                 315                 320 


Gly Glu Tyr Glu Val Ile Phe Lys Glu Gln Leu Ser Pro Lys Lys Leu 
                325                 330                 335     


Gly Phe Leu Asn Val Thr Glu Leu Val Gly Ala Leu Ser Asp Ile Leu 
            340                 345                 350         


His Val Glu Phe Arg Lys Gly His Gln Asp Leu Leu Val Phe Asp Ala 
        355                 360                 365             


Asp Lys Lys Pro Leu Pro Pro Val Gln Ser Asp Lys Lys Ile Glu Ala 
    370                 375                 380                 


Lys Ala Cys Val Ser Ser Pro Pro Arg Asn Ser Leu Ser Thr Ala Ala 
385                 390                 395                 400 


Val Lys Glu Thr Val Trp Asn Cys Pro Ser Lys Lys Gln Lys Glu Pro 
                405                 410                 415     


Gln Gln Lys Ile Cys Lys Lys Pro Asn Leu Val Val Lys Pro Leu Gln 
            420                 425                 430         


Leu Gln Val Glu Thr Asn Lys Ser Glu Leu Asn Leu Ala Met Ala Asn 
        435                 440                 445             


His Asp Ile Pro Pro Asp Ala Val Pro Asn Lys Lys Leu Cys Arg Leu 
    450                 455                 460                 


Pro Pro Leu Asp Thr Ser Ser Leu Ile Gly Val Phe Val Glu Tyr Ile 
465                 470                 475                 480 


Ile Ser Pro Ser Gln Phe Tyr Ile Arg Ile Tyr Ser Arg Asp Ser Ser 
                485                 490                 495     


Glu Leu Leu Glu Asp Met Met Ile Glu Met Arg Arg Cys Tyr Ser Asn 
            500                 505                 510         


Gln Leu Val Ser Asp Arg Tyr Val Met Pro Glu Cys Phe Ile Gln Pro 
        515                 520                 525             


Gly His Leu Cys Cys Val Arg Ile Ser Glu Asp Lys Trp Trp Tyr Arg 
    530                 535                 540                 


Val Ile Ile His Arg Val Leu Glu Lys Gln Glu Val Glu Val Phe Tyr 
545                 550                 555                 560 


Pro Asp Phe Gly Asn Ile Gly Ile Val Gln Lys Ser Ser Leu Arg Phe 
                565                 570                 575     


Leu Lys Cys Cys Tyr Thr Lys Leu Pro Ala Gln Ala Ile Pro Cys Ser 
            580                 585                 590         


Leu Ala Trp Val Arg Pro Val Glu Glu His Trp Thr Ser Lys Ala Ile 
        595                 600                 605             


Leu Gln Phe Gln Lys Leu Cys Gly Leu Lys Pro Leu Val Gly Val Val 
    610                 615                 620                 


Asp Glu Tyr Val Asp Gly Ile Leu Asn Ile Phe Leu Cys Asp Thr Ser 
625                 630                 635                 640 


Ser Asn Glu Asp Val Tyr Phe His His Val Leu Arg Thr Glu Gly His 
                645                 650                 655     


Ala Ile Val Cys Arg Glu Asn Ile Ser Ser Lys Gly Phe Ser Glu Leu 
            660                 665                 670         


Asn Pro Leu Ala Leu Tyr Thr Thr Ser Ser Gly Gly Pro Glu Asp Ile 
        675                 680                 685             


Val Leu Thr Glu Leu Gly Tyr Pro Ser Gln Gln His Tyr Phe Asn Glu 
    690                 695                 700                 


Asp Arg Lys Ile Ser Pro Gln Ser Lys Glu Ser Glu Leu Arg Ile Leu 
705                 710                 715                 720 


Asp Glu Ile Pro Thr Gly Met Pro Cys Leu Glu Ser Val Thr Ile Gly 
                725                 730                 735     


Asp Asp Ile Trp Asp Glu Asn Trp Leu Pro Leu Gln Ala Lys Met Gly 
            740                 745                 750         


Lys Gly Gly Asp Ala Ala Ser His Leu Phe Thr Ala Ser Leu Gly Gly 
        755                 760                 765             


Lys Asn Gln Tyr Ser Ser Cys Lys Glu Met Pro Gln Lys Asp Trp Cys 
    770                 775                 780                 


Phe Ser Thr Pro Lys Asp Thr Trp Asp Asp Ser Trp Gln Pro Ser Gly 
785                 790                 795                 800 


Leu Val Asn Gly Thr Lys Val Glu Val His Lys Pro Glu Val Leu Gly 
                805                 810                 815     


Ala Gln Glu Lys Asn Thr Gly Thr Asn Arg Thr Gln Lys Gln Leu Asp 
            820                 825                 830         


Ile Asn Gly Ser Ser Asp Ser Ser Thr Leu Pro Lys Leu Glu Glu Phe 
        835                 840                 845             


Cys Thr Ser Leu Thr Gln Ser Glu Gln Ser Ala Asp Gly Ser Gln Ser 
    850                 855                 860                 


Glu Pro Asn Asn Ser Gln Thr Gln Pro Lys Gln Ile Gln Leu Ser Thr 
865                 870                 875                 880 


Ala Ala Pro Cys Ser Thr Thr Ala Val Asp Asp Ser Ala Glu Lys Pro 
                885                 890                 895     


Ser Gly Ser Val Glu Ser Ser Pro Glu Ile Leu Lys Asn Glu Asp Phe 
            900                 905                 910         


Ser Ser Ser Arg Ala Ile Thr Leu Tyr Lys Asp Lys Arg Gln Glu Ser 
        915                 920                 925             


Val Asp Gln Leu Ser Leu Ile Leu Ser Tyr Glu Cys Gln Ile Ser Gln 
    930                 935                 940                 


Lys Leu Tyr Ile Pro Arg Ser Thr Ala Thr Ala Ala Leu Gly Ala Ala 
945                 950                 955                 960 


Ala Arg Leu Ala Thr Ser Arg Ser Leu Leu His Trp Tyr Pro Ser Val 
                965                 970                 975     


Lys Arg Met Glu Ala 
            980     


<210> 5144
<211> 302
<212> PRT
<213> Homo sapiens

<400> 5144
Met Glu Ile Gln Glu Leu Glu Glu Ile Gln Ala Cys Gln Gly Leu Trp 
1               5                   10                  15      


Glu Val Phe Val Thr Leu Ser Glu Arg Ala Arg Asp Tyr Leu His Lys 
            20                  25                  30          


Thr Gly Arg Phe Ile Val Ile Gly Gly Ile Val Ser Pro Val His Asp 
        35                  40                  45              


Ser Tyr Gly Lys Gln Gly Leu Val Ser Ser Arg His Arg Leu Ile Met 
    50                  55                  60                  


Cys Gln Leu Ala Val Gln Asn Ser Asp Trp Ile Arg Val Asp Pro Trp 
65                  70                  75                  80  


Glu Cys Tyr Gln Asp Thr Trp Gln Thr Thr Cys Ser Val Leu Glu His 
                85                  90                  95      


His Arg Asp Leu Met Lys Arg Val Thr Gly Cys Ile Leu Ser Asn Val 
            100                 105                 110         


Asn Thr Pro Ser Met Thr Pro Val Ile Gly Gln Pro Gln Asn Glu Thr 
        115                 120                 125             


Pro Gln Pro Ile Tyr Gln Asn Ser Asn Val Ala Thr Lys Pro Thr Ala 
    130                 135                 140                 


Ala Lys Ile Leu Gly Lys Val Gly Glu Ser Leu Ser Arg Ile Cys Cys 
145                 150                 155                 160 


Val Arg Pro Pro Val Glu Arg Phe Thr Phe Val Asp Glu Asn Ala Asn 
                165                 170                 175     


Leu Gly Thr Val Met Arg Tyr Glu Glu Ile Glu Leu Arg Ile Leu Leu 
            180                 185                 190         


Leu Cys Gly Ser Asp Leu Leu Glu Ser Phe Cys Ile Pro Gly Leu Trp 
        195                 200                 205             


Asn Glu Ala Asp Met Glu Val Ile Val Gly Asp Phe Gly Ile Val Val 
    210                 215                 220                 


Val Pro Arg Asp Ala Ala Asp Thr Asp Arg Ile Met Asn His Ser Ser 
225                 230                 235                 240 


Ile Leu Arg Lys Tyr Lys Asn Asn Ile Met Val Val Lys Asp Asp Ile 
                245                 250                 255     


Asn His Pro Met Ser Val Val Ser Ser Thr Lys Ser Arg Leu Ala Leu 
            260                 265                 270         


Gln His Gly Asp Gly His Val Val Asp Tyr Leu Ser Gln Pro Val Ile 
        275                 280                 285             


Asp Tyr Ile Leu Lys Ser Gln Leu Tyr Ile Asn Ala Ser Gly 
    290                 295                 300         


<210> 5145
<211> 286
<212> PRT
<213> Homo sapiens

<400> 5145
Met Glu Arg Arg Leu Gly Val Arg Ala Trp Val Lys Glu Asn Arg Gly 
1               5                   10                  15      


Ser Phe Gln Pro Pro Val Cys Asn Lys Leu Met His Gln Glu Gln Leu 
            20                  25                  30          


Lys Val Met Phe Ile Gly Gly Pro Asn Thr Arg Lys Asp Tyr His Ile 
        35                  40                  45              


Glu Glu Gly Glu Glu Val Phe Tyr Gln Leu Glu Gly Asp Met Val Leu 
    50                  55                  60                  


Arg Val Leu Glu Gln Gly Lys His Arg Asp Val Val Ile Arg Gln Gly 
65                  70                  75                  80  


Glu Ile Phe Leu Leu Pro Ala Arg Val Pro His Ser Pro Gln Arg Phe 
                85                  90                  95      


Ala Asn Thr Val Gly Leu Val Val Glu Arg Arg Arg Leu Glu Thr Glu 
            100                 105                 110         


Leu Asp Gly Leu Arg Tyr Tyr Val Gly Asp Thr Met Asp Val Leu Phe 
        115                 120                 125             


Glu Lys Trp Phe Tyr Cys Lys Asp Leu Gly Thr Gln Leu Ala Pro Ile 
    130                 135                 140                 


Ile Gln Glu Phe Phe Ser Ser Glu Gln Tyr Arg Thr Gly Lys Pro Ile 
145                 150                 155                 160 


Pro Asp Gln Leu Leu Lys Glu Pro Pro Phe Pro Leu Ser Thr Arg Ser 
                165                 170                 175     


Ile Met Glu Pro Met Ser Leu Asp Ala Trp Leu Asp Ser His His Arg 
            180                 185                 190         


Glu Leu Gln Ala Gly Thr Pro Leu Ser Leu Phe Gly Asp Thr Tyr Glu 
        195                 200                 205             


Thr Gln Val Ile Ala Tyr Gly Gln Gly Ser Ser Glu Gly Leu Arg Gln 
    210                 215                 220                 


Asn Val Asp Val Trp Leu Trp Gln Leu Glu Gly Ser Ser Val Val Thr 
225                 230                 235                 240 


Met Gly Gly Arg Arg Leu Ser Leu Ala Pro Asp Asp Ser Leu Leu Val 
                245                 250                 255     


Leu Ala Gly Thr Ser Tyr Ala Trp Glu Arg Thr Gln Gly Ser Val Ala 
            260                 265                 270         


Leu Ser Val Thr Gln Asp Pro Ala Cys Lys Lys Pro Leu Gly 
        275                 280                 285     


<210> 5146
<211> 514
<212> PRT
<213> Homo sapiens

<400> 5146
Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala Thr Lys Phe 
1               5                   10                  15      


Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu Asn Asp Leu 
            20                  25                  30          


Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile Val Val Arg 
        35                  40                  45              


Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile Val Arg Met 
    50                  55                  60                  


Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu Glu Asp Gly 
65                  70                  75                  80  


Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu Thr Pro Leu 
                85                  90                  95      


Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr Leu Met Cys 
            100                 105                 110         


Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu Gly Lys Gly 
        115                 120                 125             


Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr Tyr Leu Pro 
    130                 135                 140                 


Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu Leu Arg Gln 
145                 150                 155                 160 


Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn Thr Lys Leu 
                165                 170                 175     


Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His Val Cys Ser 
            180                 185                 190         


Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr Glu His Cys 
        195                 200                 205             


Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr Lys Leu Ala 
    210                 215                 220                 


Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val Asp Pro Asp 
225                 230                 235                 240 


Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His Ala Tyr Gly 
                245                 250                 255     


Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu Val Ala Cys 
            260                 265                 270         


Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val Gln Thr Gly 
        275                 280                 285             


Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser Leu Thr Ser 
    290                 295                 300                 


Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly Gly Gln Arg 
305                 310                 315                 320 


Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu Asp Ser Trp 
                325                 330                 335     


Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp Gly Lys Thr 
            340                 345                 350         


Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr Asn Phe Glu 
        355                 360                 365             


Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro Ile Met Ser 
    370                 375                 380                 


Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn Val Ala Thr 
385                 390                 395                 400 


Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu Val Arg Lys 
                405                 410                 415     


Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser Cys Phe Gly 
            420                 425                 430         


Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp His Lys Val 
        435                 440                 445             


Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu Leu Thr Gly 
    450                 455                 460                 


His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln Ile Pro Ser 
465                 470                 475                 480 


Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile Trp Gly Pro 
                485                 490                 495     


Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys Ser Ser Met 
            500                 505                 510         


Asp Ser 
        


<210> 5147
<211> 179
<212> PRT
<213> Homo sapiens

<400> 5147
Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                85                  90                  95      


Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
    130                 135                 140                 


Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
145                 150                 155                 160 


Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                165                 170                 175     


Lys Ile Arg 
            


<210> 5148
<211> 475
<212> PRT
<213> Homo sapiens

<400> 5148
Met Gln Lys Ser Thr Asn Ser Asp Thr Ser Val Glu Thr Leu Asn Ser 
1               5                   10                  15      


Thr Arg Gln Gly Thr Gly Ala Val Gln Met Arg Ile Lys Asn Ala Asn 
            20                  25                  30          


Ser His His Asp Arg Leu Ser Gln Ser Lys Ser Met Ile Leu Thr Asp 
        35                  40                  45              


Val Gly Lys Val Thr Glu Pro Ile Ser Arg His Arg Arg Asn His Ser 
    50                  55                  60                  


Gln His Ile Leu Lys Asp Val Ile Pro Pro Leu Glu Gln Leu Met Val 
65                  70                  75                  80  


Glu Lys Glu Gly Tyr Leu Gln Lys Ala Lys Ile Ala Asp Gly Gly Lys 
                85                  90                  95      


Lys Leu Arg Lys Asn Trp Ser Thr Ser Trp Ile Val Leu Ser Ser Arg 
            100                 105                 110         


Arg Ile Glu Phe Tyr Lys Glu Ser Lys Gln Gln Ala Leu Ser Asn Met 
        115                 120                 125             


Lys Thr Gly His Lys Pro Glu Ser Val Asp Leu Cys Gly Ala His Ile 
    130                 135                 140                 


Glu Trp Ala Lys Glu Lys Ser Ser Arg Lys Asn Val Phe Gln Ile Thr 
145                 150                 155                 160 


Thr Val Ser Gly Asn Glu Phe Leu Leu Gln Ser Asp Ile Asp Phe Ile 
                165                 170                 175     


Ile Leu Asp Trp Phe His Ala Ile Lys Asn Ala Ile Asp Arg Leu Pro 
            180                 185                 190         


Lys Asp Ser Ser Cys Pro Ser Arg Asn Leu Glu Leu Phe Lys Ile Gln 
        195                 200                 205             


Arg Ser Ser Ser Thr Glu Leu Leu Ser His Tyr Asp Ser Asp Ile Lys 
    210                 215                 220                 


Glu Gln Lys Pro Glu His Arg Lys Ser Leu Met Phe Arg Leu His His 
225                 230                 235                 240 


Ser Ala Ser Asp Thr Ser Asp Lys Asn Arg Val Lys Ser Arg Leu Lys 
                245                 250                 255     


Lys Phe Ile Thr Arg Arg Pro Ser Leu Lys Thr Leu Gln Glu Lys Gly 
            260                 265                 270         


Leu Ile Lys Asp Gln Ile Phe Gly Ser His Leu His Lys Val Cys Glu 
        275                 280                 285             


Arg Glu Asn Ser Thr Val Pro Trp Phe Val Lys Gln Cys Ile Glu Ala 
    290                 295                 300                 


Val Glu Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val Ser Gly 
305                 310                 315                 320 


Asn Leu Ala Thr Ile Gln Lys Leu Arg Phe Ile Val Asn Gln Glu Glu 
                325                 330                 335     


Lys Leu Asn Leu Asp Asp Ser Gln Trp Glu Asp Ile His Val Val Thr 
            340                 345                 350         


Gly Ala Leu Lys Met Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro 
        355                 360                 365             


Tyr Ser Phe Phe Glu Gln Phe Val Glu Ala Ile Lys Lys Gln Asp Asn 
    370                 375                 380                 


Asn Thr Arg Ile Glu Ala Val Lys Ser Leu Val Gln Lys Leu Pro Pro 
385                 390                 395                 400 


Pro Asn Arg Asp Thr Met Lys Val Leu Phe Gly His Leu Thr Lys Ile 
                405                 410                 415     


Val Ala Lys Ala Ser Lys Asn Leu Met Ser Thr Gln Ser Leu Gly Ile 
            420                 425                 430         


Val Phe Gly Pro Thr Leu Leu Arg Ala Glu Asn Glu Thr Gly Asn Met 
        435                 440                 445             


Ala Ile His Met Val Tyr Gln Asn Gln Ile Ala Glu Leu Met Leu Ser 
    450                 455                 460                 


Glu Tyr Ser Lys Ile Phe Gly Ser Glu Glu Asp 
465                 470                 475 


<210> 5149
<211> 435
<212> PRT
<213> Homo sapiens

<400> 5149
Met Ala Gln Thr Val Pro Pro Cys Glu Leu Pro Cys Lys Glu Tyr Asp 
1               5                   10                  15      


Val Ala Arg Asn Thr Gly Ala Tyr Thr Ser Ser Gly Leu Ala Thr Ala 
            20                  25                  30          


Ser Phe Arg Thr Ser Lys Tyr Leu Leu Glu Glu Trp Phe Gln Asn Cys 
        35                  40                  45              


Tyr Ala Arg Tyr His Gln Ala Phe Ala Asp Arg Asp Gln Ser Glu Arg 
    50                  55                  60                  


Gln Arg His Glu Ser Gln Gln Leu Ala Thr Glu Thr Gln Ala Leu Ala 
65                  70                  75                  80  


Gln Arg Thr Gln Gln Asp Ser Thr Arg Thr Val Gly Glu Arg Leu Gln 
                85                  90                  95      


Asp Thr His Ser Trp Lys Ser Glu Leu Gln Arg Glu Met Glu Ala Leu 
            100                 105                 110         


Ala Ala Glu Thr Asn Leu Leu Leu Ala Gln Lys Gln Arg Leu Glu Arg 
        115                 120                 125             


Ala Leu Asp Ala Thr Glu Val Pro Phe Ser Ile Thr Thr Asp Asn Leu 
    130                 135                 140                 


Gln Cys Arg Glu Arg Arg Glu His Pro Asn Leu Val Arg Asp His Val 
145                 150                 155                 160 


Glu Thr Glu Leu Leu Lys Glu Ala Glu Leu Ile Arg Asn Ile Gln Glu 
                165                 170                 175     


Leu Leu Lys Arg Thr Ile Met Gln Ala Val Ser Gln Ile Arg Leu Asn 
            180                 185                 190         


Arg Glu His Lys Glu Thr Cys Glu Met Asp Trp Ser Asp Lys Met Glu 
        195                 200                 205             


Ala Tyr Asn Ile Asp Glu Thr Cys Gly Arg His His Ser Gln Ser Thr 
    210                 215                 220                 


Glu Val Gln Ala His Pro Tyr Ser Thr Thr Phe Gln Glu Ser Ala Ser 
225                 230                 235                 240 


Thr Pro Glu Thr Arg Ala Lys Phe Thr Gln Asp Asn Leu Cys Arg Ala 
                245                 250                 255     


Gln Arg Glu Arg Leu Ala Ser Ala Asn Leu Arg Val Leu Val Asp Cys 
            260                 265                 270         


Ile Leu Arg Asp Thr Ser Glu Asp Leu Arg Leu Gln Cys Asp Ala Val 
        275                 280                 285             


Asn Leu Ala Phe Gly Arg Arg Cys Glu Glu Leu Glu Asp Ala Arg Tyr 
    290                 295                 300                 


Lys Leu His His His Leu His Lys Thr Leu Arg Glu Ile Thr Asp Gln 
305                 310                 315                 320 


Glu His Asn Val Ala Ala Leu Lys Gln Ala Ile Lys Asp Lys Glu Ala 
                325                 330                 335     


Pro Leu His Val Ala Gln Thr Arg Leu Tyr Leu Arg Ser His Arg Pro 
            340                 345                 350         


Asn Met Glu Leu Cys Arg Asp Ala Ala Gln Phe Arg Leu Leu Ser Glu 
        355                 360                 365             


Val Glu Glu Leu Asn Met Ser Leu Thr Ala Leu Arg Glu Lys Leu Leu 
    370                 375                 380                 


Glu Ala Glu Gln Ser Leu Arg Asn Leu Glu Asp Ile His Met Ser Leu 
385                 390                 395                 400 


Glu Lys Asp Ile Ala Ala Met Thr Asn Ser Leu Phe Ile Asp Arg Gln 
                405                 410                 415     


Lys Cys Met Ala His Arg Thr Arg Tyr Pro Thr Ile Leu Gln Leu Ala 
            420                 425                 430         


Gly Tyr Gln 
        435 


<210> 5150
<211> 275
<212> PRT
<213> Homo sapiens

<400> 5150
Met Arg Lys Arg Leu Ser Ala Pro Glu Leu Arg Leu Ser Leu Thr Lys 
1               5                   10                  15      


Gly Pro Gly Asn Asp Gly Ala Ser Pro Thr Gln Ser Ala Pro Ser Ser 
            20                  25                  30          


Pro Asp Gly Ser Ser Asp Leu Glu Ile Asp Glu Leu Glu Thr Pro Ser 
        35                  40                  45              


Asp Ser Glu Gln Leu Asp Ser Gly His Glu Phe Glu Trp Glu Asp Glu 
    50                  55                  60                  


Leu Pro Arg Ala Glu Gly Leu Gly Thr Ser Glu Thr Ala Glu Arg Leu 
65                  70                  75                  80  


Gly Arg Gly Cys Met Trp Asp Val Thr Gly Glu Asp Gly His His Trp 
                85                  90                  95      


Arg Val Phe Arg Met Gly Pro Arg Glu Gln Arg Val Asp Met Thr Val 
            100                 105                 110         


Ile Glu Pro Tyr Lys Lys Val Leu Ser His Gly Gly Tyr His Gly Asp 
        115                 120                 125             


Gly Leu Asn Ala Val Ile Leu Phe Ala Ser Cys Tyr Leu Pro Arg Ser 
    130                 135                 140                 


Ser Ile Pro Asn Tyr Thr Tyr Val Met Glu His Leu Phe Arg Tyr Met 
145                 150                 155                 160 


Val Gly Thr Leu Glu Leu Leu Val Ala Glu Asn Tyr Leu Leu Val His 
                165                 170                 175     


Leu Ser Gly Gly Thr Ser Arg Ala Gln Val Pro Pro Leu Ser Trp Ile 
            180                 185                 190         


Arg Gln Cys Tyr Arg Thr Leu Asp Arg Arg Leu Arg Lys Asn Leu Arg 
        195                 200                 205             


Ala Leu Val Val Val His Ala Thr Trp Tyr Val Lys Ala Phe Leu Ala 
    210                 215                 220                 


Leu Leu Arg Pro Phe Ile Ser Ser Lys Phe Thr Arg Lys Ile Arg Phe 
225                 230                 235                 240 


Leu Asp Ser Leu Gly Glu Leu Ala Gln Leu Ile Ser Leu Asp Gln Val 
                245                 250                 255     


His Ile Pro Glu Ala Val Arg Gln Leu Asp Arg Asp Leu His Gly Ser 
            260                 265                 270         


Gly Gly Thr 
        275 


<210> 5151
<211> 796
<212> PRT
<213> Homo sapiens

<400> 5151
Met Glu Glu Glu Ala Ser Arg Ser Ala Ala Ala Thr Asn Pro Gly Ser 
1               5                   10                  15      


Arg Leu Thr Arg Trp Pro Pro Pro Asp Lys Arg Glu Gly Ser Ala Val 
            20                  25                  30          


Asp Pro Gly Lys Arg Arg Ser Leu Ala Ala Thr Pro Ser Ser Ser Leu 
        35                  40                  45              


Pro Cys Thr Leu Ile Ala Leu Gly Leu Arg His Glu Lys Glu Ala Asn 
    50                  55                  60                  


Glu Leu Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe 
65                  70                  75                  80  


Ser Asn Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu 
                85                  90                  95      


Pro Gln Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu 
            100                 105                 110         


Leu Ala Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe 
        115                 120                 125             


Glu Gln Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val 
    130                 135                 140                 


Glu Lys Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu 
145                 150                 155                 160 


Asp Pro Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val 
                165                 170                 175     


Gln Leu Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu 
            180                 185                 190         


Asn Pro Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr 
        195                 200                 205             


Phe Ala Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe 
    210                 215                 220                 


Gln Thr Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile 
225                 230                 235                 240 


Glu Asp Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr 
                245                 250                 255     


Val Lys Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys Gln Val Ala 
            260                 265                 270         


Trp Ile Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu Leu Leu Pro 
        275                 280                 285             


Val Cys Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile Leu Phe Thr 
    290                 295                 300                 


Lys Ala Glu Asp Asn Lys Tyr Leu Leu Thr Cys Lys Thr Ala Arg Gln 
305                 310                 315                 320 


Leu Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala Pro Asp Asn 
                325                 330                 335     


Ile Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu Gly Lys 
            340                 345                 350         


Cys Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro Ile Glu Arg 
        355                 360                 365             


Glu Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro Ser Ile 
    370                 375                 380                 


Gln Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu Val Gly Asn 
385                 390                 395                 400 


Met Thr Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu Glu Lys Asp 
                405                 410                 415     


Asn Ser Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu Leu Pro Lys 
            420                 425                 430         


Gly Val Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe Pro Lys Lys 
        435                 440                 445             


Ala Trp Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu Leu Ile Gln 
    450                 455                 460                 


Pro Ser Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys Thr Pro Ala 
465                 470                 475                 480 


Gln Ser Thr His Ser Glu Ala Pro Pro Ser Lys Met Val Leu Arg Ile 
                485                 490                 495     


Pro His Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val Pro Gly Val 
            500                 505                 510         


Pro Pro Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser Pro Ala Ala 
        515                 520                 525             


Leu Pro Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro Leu Ser Glu 
    530                 535                 540                 


Ser Gln Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val Met Met Pro 
545                 550                 555                 560 


Ser Pro Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg Arg Arg Pro 
                565                 570                 575     


Ser Lys Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys Pro Ala Pro 
            580                 585                 590         


Val Ile His Pro Ala Ser Val Ile Phe Thr Val Pro Ala Thr Thr Val 
        595                 600                 605             


Lys Ile Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln Pro Val Asn 
    610                 615                 620                 


Ala Ala Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala Thr Leu Leu 
625                 630                 635                 640 


Val Asn Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro Leu Val Ala 
                645                 650                 655     


Ser Ser Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val Asn Leu Pro 
            660                 665                 670         


Ile Pro Ser Thr Pro Glu Asp Lys Ala His Met Asn Val Asp Ile Ala 
        675                 680                 685             


Cys Ala Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu Glu Pro Lys 
    690                 695                 700                 


Leu Glu Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val Phe Pro Lys 
705                 710                 715                 720 


Val Glu His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln Cys Gln Glu 
                725                 730                 735     


Gly Leu Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val Lys Thr Glu 
            740                 745                 750         


Glu Gly Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile Gln Glu Ser 
        755                 760                 765             


Leu Asn Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val Lys Met Glu 
    770                 775                 780                 


Pro Glu Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
785                 790                 795     


<210> 5152
<211> 459
<212> PRT
<213> Homo sapiens

<400> 5152
Met Ala Ala Ser Ala Ser Ala Ala Ala Gly Glu Glu Asp Trp Val Leu 
1               5                   10                  15      


Pro Ser Glu Val Glu Val Leu Glu Ser Ile Tyr Leu Asp Glu Leu Gln 
            20                  25                  30          


Val Ile Lys Gly Asn Gly Arg Thr Ser Pro Trp Glu Ile Tyr Ile Thr 
        35                  40                  45              


Leu His Pro Ala Thr Ala Glu Asp Gln Asp Ser Gln Tyr Val Cys Phe 
    50                  55                  60                  


Thr Leu Val Leu Gln Val Pro Ala Glu Tyr Pro His Glu Val Pro Gln 
65                  70                  75                  80  


Ile Ser Ile Arg Asn Pro Arg Gly Leu Ser Asp Glu Gln Ile His Thr 
                85                  90                  95      


Ile Leu Gln Val Leu Gly His Val Ala Lys Ala Gly Leu Gly Thr Ala 
            100                 105                 110         


Met Leu Tyr Glu Leu Ile Glu Lys Gly Lys Glu Ile Leu Thr Asp Asn 
        115                 120                 125             


Asn Ile Pro His Gly Gln Cys Val Ile Cys Leu Tyr Gly Phe Gln Glu 
    130                 135                 140                 


Lys Glu Ala Phe Thr Lys Thr Pro Cys Tyr His Tyr Phe His Cys His 
145                 150                 155                 160 


Cys Leu Ala Arg Tyr Ile Gln His Met Glu Gln Glu Leu Lys Ala Gln 
                165                 170                 175     


Gly Gln Glu Gln Glu Gln Glu Arg Gln His Ala Thr Thr Lys Gln Lys 
            180                 185                 190         


Ala Val Gly Val Gln Cys Pro Val Cys Arg Glu Pro Leu Val Tyr Asp 
        195                 200                 205             


Leu Ala Ser Leu Lys Ala Ala Pro Glu Pro Gln Gln Pro Met Glu Leu 
    210                 215                 220                 


Tyr Gln Pro Ser Ala Glu Ser Leu Arg Gln Gln Glu Glu Arg Lys Arg 
225                 230                 235                 240 


Leu Tyr Gln Arg Gln Gln Glu Arg Gly Gly Ile Ile Asp Leu Glu Ala 
                245                 250                 255     


Glu Arg Asn Arg Tyr Phe Ile Ser Leu Gln Gln Pro Pro Ala Pro Ala 
            260                 265                 270         


Glu Pro Glu Ser Ala Val Asp Val Ser Lys Gly Ser Gln Pro Pro Ser 
        275                 280                 285             


Thr Leu Ala Ala Glu Leu Ser Thr Ser Pro Ala Val Gln Ser Thr Leu 
    290                 295                 300                 


Pro Pro Pro Leu Pro Val Ala Thr Gln His Ile Cys Glu Lys Ile Pro 
305                 310                 315                 320 


Gly Thr Arg Ser Asn Gln Gln Arg Leu Gly Glu Thr Gln Lys Ala Met 
                325                 330                 335     


Leu Asp Pro Pro Lys Pro Ser Arg Gly Pro Trp Arg Gln Pro Glu Arg 
            340                 345                 350         


Arg His Pro Lys Gly Gly Glu Cys His Ala Pro Lys Gly Thr Arg Asp 
        355                 360                 365             


Thr Gln Glu Leu Pro Pro Pro Glu Gly Pro Leu Lys Glu Pro Met Asp 
    370                 375                 380                 


Leu Lys Pro Glu Pro His Ser Gln Gly Val Glu Gly Pro Pro Gln Glu 
385                 390                 395                 400 


Lys Gly Pro Gly Ser Trp Gln Gly Pro Pro Pro Arg Arg Thr Arg Asp 
                405                 410                 415     


Cys Val Arg Trp Glu Arg Ser Lys Gly Arg Thr Pro Gly Ser Ser Tyr 
            420                 425                 430         


Pro Arg Leu Pro Arg Gly Gln Gly Ala Tyr Arg Pro Gly Thr Arg Arg 
        435                 440                 445             


Glu Ser Leu Gly Leu Glu Ser Lys Asp Gly Ser 
    450                 455                 


<210> 5153
<211> 692
<212> PRT
<213> Homo sapiens

<400> 5153
Met Gly Ser Ala Ala Asp Val Arg Phe Ser Leu Gly Thr Thr Thr His 
1               5                   10                  15      


Ala Pro Pro Gly Val His Arg Arg Tyr Ser Ala Leu Arg Glu Glu Ser 
            20                  25                  30          


Ala Lys Asp Trp Glu Thr Ser Pro Leu Pro Gly Met Leu Ala Pro Ala 
        35                  40                  45              


Ala Gly Pro Ala Phe Asp Ser Asp Pro Glu Ile Ser Asp Val Asp Glu 
    50                  55                  60                  


Asp Glu Pro Gly Gly Leu Val Gly Ser Ala Asp Val Val Ser Pro Ser 
65                  70                  75                  80  


Gly His Ser Asp Ala Gln Thr Leu Ala Met Met Leu Gln Glu Gln Leu 
                85                  90                  95      


Asp Ala Ile Asn Glu Glu Ile Arg Met Ile Gln Glu Glu Lys Glu Ser 
            100                 105                 110         


Thr Glu Leu Arg Ala Glu Glu Ile Glu Thr Arg Val Thr Ser Gly Ser 
        115                 120                 125             


Met Glu Ala Leu Asn Leu Lys Gln Leu Arg Lys Arg Gly Ser Ile Pro 
    130                 135                 140                 


Thr Ser Leu Thr Ala Leu Ser Leu Ala Ser Ala Ser Pro Pro Leu Ser 
145                 150                 155                 160 


Gly Arg Ser Thr Pro Lys Leu Thr Ser Arg Ser Ala Ala Gln Asp Leu 
                165                 170                 175     


Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp Leu Arg Lys His Arg 
            180                 185                 190         


Arg Lys Leu Leu Ser Pro Val Ser Arg Glu Glu Asn Arg Glu Asp Lys 
        195                 200                 205             


Ala Thr Ile Lys Cys Glu Thr Ser Pro Pro Ser Ser Pro Arg Thr Leu 
    210                 215                 220                 


Arg Leu Glu Lys Leu Gly His Pro Ala Leu Ser Gln Glu Glu Gly Lys 
225                 230                 235                 240 


Ser Ala Leu Glu Asp Gln Gly Ser Asn Pro Ser Ser Ser Asn Ser Ser 
                245                 250                 255     


Gln Asp Ser Leu His Lys Gly Ala Lys Arg Lys Gly Ile Lys Ser Ser 
            260                 265                 270         


Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Gly Arg Leu Ile Gln Leu 
        275                 280                 285             


Ser Arg Asp Gly Ala Thr Gly His Val Leu Leu Thr Asp Ser Glu Phe 
    290                 295                 300                 


Ser Met Gln Glu Pro Met Val Pro Ala Lys Leu Gly Thr Gln Ala Glu 
305                 310                 315                 320 


Lys Asp Arg Arg Leu Lys Lys Lys His Gln Leu Leu Glu Asp Ala Arg 
                325                 330                 335     


Arg Lys Gly Met Pro Phe Ala Gln Trp Asp Gly Pro Thr Val Val Ser 
            340                 345                 350         


Trp Leu Glu Leu Trp Val Gly Met Pro Ala Trp Tyr Val Ala Ala Cys 
        355                 360                 365             


Arg Ala Asn Val Lys Ser Gly Ala Ile Met Ser Ala Leu Ser Asp Thr 
    370                 375                 380                 


Glu Ile Gln Arg Glu Ile Gly Ile Ser Asn Ala Leu His Arg Leu Lys 
385                 390                 395                 400 


Leu Arg Leu Ala Ile Gln Glu Met Val Ser Leu Thr Ser Pro Ser Ala 
                405                 410                 415     


Pro Pro Thr Ser Arg Thr Ser Ser Gly Asn Val Trp Val Thr His Glu 
            420                 425                 430         


Glu Met Glu Thr Leu Glu Thr Ser Thr Lys Thr Thr Leu Ala Tyr Gly 
        435                 440                 445             


Asp Met Asn His Glu Trp Ile Gly Asn Glu Trp Leu Pro Ser Leu Gly 
    450                 455                 460                 


Leu Pro Gln Tyr Arg Ser Tyr Phe Met Glu Cys Leu Val Asp Ala Arg 
465                 470                 475                 480 


Met Leu Asp His Leu Thr Lys Lys Asp Leu Arg Val His Leu Lys Met 
                485                 490                 495     


Val Asp Ser Phe His Arg Thr Ser Leu Gln Tyr Gly Ile Met Cys Leu 
            500                 505                 510         


Lys Arg Leu Asn Tyr Asp Arg Lys Glu Leu Glu Lys Arg Arg Glu Glu 
        515                 520                 525             


Ser Gln His Glu Ile Lys Asp Val Leu Val Trp Thr Asn Asp Gln Val 
    530                 535                 540                 


Val His Trp Val Gln Ser Ile Gly Leu Arg Asp Tyr Ala Gly Asn Leu 
545                 550                 555                 560 


His Glu Ser Gly Val His Gly Ala Leu Leu Ala Leu Asp Glu Asn Phe 
                565                 570                 575     


Asp His Asn Thr Leu Ala Leu Ile Leu Gln Ile Pro Thr Gln Asn Thr 
            580                 585                 590         


Gln Ala Arg Gln Val Met Glu Arg Glu Phe Asn Asn Leu Leu Ala Leu 
        595                 600                 605             


Gly Thr Asp Arg Lys Leu Asp Asp Gly Asp Asp Lys Val Phe Arg Arg 
    610                 615                 620                 


Ala Pro Ser Trp Arg Lys Arg Phe Arg Pro Arg Glu His His Gly Arg 
625                 630                 635                 640 


Gly Gly Met Leu Ser Ala Ser Ala Glu Thr Leu Pro Ala Gly Phe Arg 
                645                 650                 655     


Val Ser Thr Leu Gly Thr Leu Gln Pro Pro Pro Ala Pro Pro Lys Lys 
            660                 665                 670         


Ile Met Pro Glu Ala His Ser His Tyr Leu Tyr Gly His Met Leu Ser 
        675                 680                 685             


Ala Phe Arg Asp 
    690         


<210> 5154
<211> 122
<212> PRT
<213> Homo sapiens

<400> 5154
Met Ala Pro Gln Lys Asp Arg Lys Pro Lys Arg Ser Thr Trp Arg Phe 
1               5                   10                  15      


Asn Leu Asp Leu Thr His Pro Val Glu Asp Gly Ile Phe Asp Ser Gly 
            20                  25                  30          


Asn Phe Glu Gln Phe Leu Arg Glu Lys Val Lys Val Asn Gly Lys Thr 
        35                  40                  45              


Gly Asn Leu Gly Asn Val Val His Ile Glu Arg Phe Lys Asn Lys Ile 
    50                  55                  60                  


Thr Val Val Ser Glu Lys Gln Phe Ser Lys Arg Tyr Leu Lys Tyr Leu 
65                  70                  75                  80  


Thr Lys Lys Tyr Leu Lys Lys Asn Asn Leu Arg Asp Trp Leu Arg Val 
                85                  90                  95      


Val Ala Ser Asp Lys Glu Thr Tyr Glu Leu Arg Tyr Phe Gln Ile Ser 
            100                 105                 110         


Gln Asp Glu Asp Glu Ser Glu Ser Glu Asp 
        115                 120         


<210> 5155
<211> 311
<212> PRT
<213> Homo sapiens

<400> 5155
Met Gln Tyr Ile Ser His Ile Phe Gly Val Ile Asn Cys Asn Gly Phe 
1               5                   10                  15      


Thr Leu Ser Asp Gln Arg Gly Leu Gln Ala Val Gly Val Gly Ile Phe 
            20                  25                  30          


Pro Asn Leu Gly Leu Val Asn His Asp Cys Trp Pro Asn Cys Thr Val 
        35                  40                  45              


Ile Phe Asn Asn Gly Lys Ile Glu Leu Arg Ala Leu Gly Lys Ile Ser 
    50                  55                  60                  


Glu Gly Glu Glu Leu Thr Val Ser Tyr Ile Asp Phe Leu Asn Val Ser 
65                  70                  75                  80  


Glu Glu Arg Lys Arg Gln Leu Lys Lys Gln Tyr Tyr Phe Asp Cys Thr 
                85                  90                  95      


Cys Glu His Cys Gln Lys Lys Leu Lys Asp Asp Leu Phe Leu Gly Val 
            100                 105                 110         


Lys Asp Asn Pro Lys Pro Ser Gln Glu Val Val Lys Glu Met Ile Gln 
        115                 120                 125             


Phe Ser Lys Asp Thr Leu Glu Lys Ile Asp Lys Ala Arg Ser Glu Gly 
    130                 135                 140                 


Leu Tyr His Glu Val Val Lys Leu Cys Arg Glu Cys Leu Glu Lys Gln 
145                 150                 155                 160 


Glu Pro Val Phe Ala Asp Thr Asn Ile Tyr Met Leu Arg Met Leu Ser 
                165                 170                 175     


Ile Val Ser Glu Val Leu Ser Tyr Leu Gln Ala Phe Glu Glu Ala Ser 
            180                 185                 190         


Phe Tyr Ala Arg Arg Met Val Asp Gly Tyr Met Lys Leu Tyr His Pro 
        195                 200                 205             


Asn Asn Ala Gln Leu Gly Met Ala Val Met Arg Ala Gly Leu Thr Asn 
    210                 215                 220                 


Trp His Ala Gly Asn Ile Glu Val Gly His Gly Met Ile Cys Lys Ala 
225                 230                 235                 240 


Tyr Ala Ile Leu Leu Val Thr His Gly Pro Ser His Pro Ile Thr Lys 
                245                 250                 255     


Asp Leu Glu Ala Met Arg Val Gln Thr Glu Met Glu Leu Arg Met Phe 
            260                 265                 270         


Arg Gln Asn Glu Phe Met Tyr Tyr Lys Met Arg Glu Ala Ala Leu Asn 
        275                 280                 285             


Asn Gln Pro Met Gln Val Met Ala Glu Pro Ser Asn Glu Pro Ser Pro 
    290                 295                 300                 


Ala Leu Phe His Lys Lys Gln 
305                 310     


<210> 5156
<211> 513
<212> PRT
<213> Homo sapiens

<400> 5156
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Trp Leu Leu Arg Phe Lys 
145                 150                 155                 160 


Val Ser Thr Gln Asn Met Lys Met Gly Gly Leu Pro Arg Thr Thr Pro 
                165                 170                 175     


Pro Thr Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Thr Leu 
            180                 185                 190         


Gly Arg His Ser Pro Tyr Arg Thr Leu Glu Pro Val Arg Pro Pro Val 
        195                 200                 205             


Val Pro Asn Asp Tyr Val Pro Ser Pro Thr Arg Asn Met Ala Pro Ser 
    210                 215                 220                 


Gln Gln Ser Pro Val Arg Thr Ala Ser Val Asn Gln Arg Asn Arg Thr 
225                 230                 235                 240 


Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser 
                245                 250                 255     


Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala 
            260                 265                 270         


Val Pro Thr Pro Ser Pro Pro Ser Val Phe Pro Ala Pro Ala Gly Ser 
        275                 280                 285             


Ala Gly Thr Pro Pro Leu Pro Ala Thr Ser Ala Ser Ala Pro Ala Pro 
    290                 295                 300                 


Leu Val Pro Ala Thr Val Pro Ser Ser Thr Ala Pro Asp Ala Ala Ala 
305                 310                 315                 320 


Gly Gly Ala Gln Thr Leu Ala Asp Gly Phe Thr Ser Pro Thr Pro Pro 
                325                 330                 335     


Val Val Ser Ser Thr Pro Pro Thr Gly His Pro Val Gln Phe Tyr Ser 
            340                 345                 350         


Met Asn Arg Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser 
        355                 360                 365             


Leu Pro Tyr Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln 
    370                 375                 380                 


Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp 
385                 390                 395                 400 


Thr Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser 
                405                 410                 415     


Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala 
            420                 425                 430         


Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala 
        435                 440                 445             


Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys 
    450                 455                 460                 


Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val 
465                 470                 475                 480 


Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Met Asn Gly Val 
                485                 490                 495     


Thr Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Ser 
            500                 505                 510         


Glu 
    


<210> 5157
<211> 389
<212> PRT
<213> Homo sapiens

<400> 5157
Met Pro Leu Glu Asn Leu Glu Glu Glu Gly Leu Pro Lys Asn Pro Asp 
1               5                   10                  15      


Leu Arg Ile Ala Gln Leu Arg Phe Leu Leu Ser Leu Pro Glu His Arg 
            20                  25                  30          


Gly Asp Ala Ala Val Arg Asp Glu Leu Met Ala Ala Val Arg Asp Asn 
        35                  40                  45              


Asn Met Ala Pro Tyr Tyr Glu Ala Leu Cys Lys Ser Leu Asp Trp Gln 
    50                  55                  60                  


Ile Asp Val Asp Leu Leu Asn Lys Met Lys Lys Ala Asn Glu Asp Glu 
65                  70                  75                  80  


Leu Lys Arg Leu Asp Glu Glu Leu Glu Asp Ala Glu Lys Asn Leu Gly 
                85                  90                  95      


Glu Ser Glu Ile Arg Asp Ala Met Met Ala Lys Ala Glu Tyr Leu Cys 
            100                 105                 110         


Arg Ile Gly Asp Lys Glu Gly Ala Leu Thr Ala Phe Arg Lys Thr Tyr 
        115                 120                 125             


Asp Lys Thr Val Ala Leu Gly His Arg Leu Asp Ile Val Phe Tyr Leu 
    130                 135                 140                 


Leu Arg Ile Gly Leu Phe Tyr Met Asp Asn Asp Leu Ile Thr Arg Asn 
145                 150                 155                 160 


Thr Glu Lys Ala Lys Ser Leu Ile Glu Glu Gly Gly Asp Trp Asp Arg 
                165                 170                 175     


Arg Asn Arg Leu Lys Val Tyr Gln Gly Leu Tyr Cys Val Ala Ile Arg 
            180                 185                 190         


Asp Phe Lys Gln Ala Ala Glu Leu Phe Leu Asp Thr Val Ser Thr Phe 
        195                 200                 205             


Thr Ser Tyr Glu Leu Met Asp Tyr Lys Thr Phe Val Thr Tyr Thr Val 
    210                 215                 220                 


Tyr Val Ser Met Ile Ala Leu Glu Arg Pro Asp Leu Arg Glu Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ala Glu Ile Leu Glu Val Leu His Ser Leu Pro Ala Val 
                245                 250                 255     


Arg Gln Tyr Leu Phe Ser Leu Tyr Glu Cys Arg Tyr Ser Val Phe Phe 
            260                 265                 270         


Gln Ser Leu Ala Val Val Glu Gln Glu Met Lys Lys Asp Trp Leu Phe 
        275                 280                 285             


Ala Pro His Tyr Arg Tyr Tyr Val Arg Glu Met Arg Ile His Ala Tyr 
    290                 295                 300                 


Ser Gln Leu Leu Glu Ser Tyr Arg Ser Leu Thr Leu Gly Tyr Met Ala 
305                 310                 315                 320 


Glu Ala Phe Gly Val Gly Val Glu Phe Ile Asp Gln Glu Leu Ser Arg 
                325                 330                 335     


Phe Ile Ala Ala Gly Arg Leu His Cys Lys Ile Asp Lys Val Asn Glu 
            340                 345                 350         


Ile Val Glu Thr Asn Arg Pro Asp Ser Lys Asn Trp Gln Tyr Gln Glu 
        355                 360                 365             


Thr Ile Lys Lys Gly Asp Leu Leu Leu Asn Arg Val Gln Lys Leu Ser 
    370                 375                 380                 


Arg Val Ile Asn Met 
385                 


<210> 5158
<211> 139
<212> PRT
<213> Homo sapiens

<400> 5158
Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      


Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val 
            20                  25                  30          


Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp 
        35                  40                  45              


Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu 
    50                  55                  60                  


Thr Tyr Pro Phe Asn Pro Pro Lys Tyr Lys Gln Asn Pro Glu Met Phe 
65                  70                  75                  80  


Lys Gln Thr Ala Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val 
                85                  90                  95      


Ser Ser Pro Glu Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly 
            100                 105                 110         


Phe Asp Arg Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp 
        115                 120                 125             


Val Glu Thr Ala Thr Glu Leu Leu Leu Ser Asn 
    130                 135                 


<210> 5159
<211> 400
<212> PRT
<213> Homo sapiens

<400> 5159
Met Asn Phe Thr Val Gly Phe Lys Pro Leu Leu Gly Asp Ala His Ser 
1               5                   10                  15      


Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
            20                  25                  30          


Phe Ser Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
        35                  40                  45              


Lys Cys Ala Asn Asp Val Phe Gln Ala Ser Asn Pro Leu Trp Gln Ser 
    50                  55                  60                  


Arg Gly Ser Thr Thr Val Ser Ser Gly Gly Arg Phe Arg Cys Pro Ser 
65                  70                  75                  80  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
                85                  90                  95      


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
            100                 105                 110         


Ser Arg Pro Leu His Ser Lys Ala Glu Gln His Leu Met Cys Glu Glu 
        115                 120                 125             


His Glu Glu Glu Lys Ile Asn Ile Tyr Cys Leu Ser Cys Glu Val Pro 
    130                 135                 140                 


Thr Cys Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Glu Val 
145                 150                 155                 160 


Ala Pro Leu Pro Thr Ile Tyr Lys Arg Gln Lys Lys Gln Asp Leu Thr 
                165                 170                 175     


Leu Leu Pro Arg Leu Glu Cys Ser Gly Thr Asn Thr Thr Tyr Cys Ser 
            180                 185                 190         


Leu Asp Leu Pro Ser Ser Ser Asp Pro Pro Ile Leu Ala Ser Gln Asn 
        195                 200                 205             


Thr Lys Ile Ile Asp Ser Glu Leu Ser Asp Gly Ile Ala Met Leu Val 
    210                 215                 220                 


Ala Gly Asn Asp Arg Val Gln Ala Val Ile Thr Gln Met Glu Glu Val 
225                 230                 235                 240 


Cys Gln Thr Ile Glu Asp Asn Ser Arg Arg Gln Lys Gln Leu Leu Asn 
                245                 250                 255     


Gln Arg Phe Glu Ser Leu Cys Ala Val Leu Glu Glu Arg Lys Gly Glu 
            260                 265                 270         


Leu Leu Gln Ala Leu Ala Arg Glu Gln Glu Glu Lys Leu Gln Arg Val 
        275                 280                 285             


Arg Gly Leu Ile Arg Gln Tyr Gly Asp His Leu Glu Ala Ser Ser Lys 
    290                 295                 300                 


Leu Val Glu Ser Ala Ile Gln Ser Met Glu Glu Pro Gln Met Ala Leu 
305                 310                 315                 320 


Tyr Leu Gln Gln Ala Lys Glu Leu Ile Asn Lys Val Gly Ala Met Ser 
                325                 330                 335     


Lys Val Glu Leu Ala Gly Arg Pro Glu Pro Gly Tyr Glu Ser Met Glu 
            340                 345                 350         


Gln Phe Thr Val Arg Val Glu His Val Ala Glu Met Leu Arg Thr Ile 
        355                 360                 365             


Asp Phe Gln Pro Gly Ala Ser Gly Glu Glu Glu Glu Val Ala Pro Asp 
    370                 375                 380                 


Gly Glu Glu Gly Ser Ala Gly Pro Glu Glu Glu Arg Pro Asp Gly Pro 
385                 390                 395                 400 


<210> 5160
<211> 65
<212> PRT
<213> Homo sapiens

<400> 5160
Met Phe Leu Ser Ala Val Phe Phe Ala Lys Ser Lys Ser Lys Asn Ile 
1               5                   10                  15      


Leu Val Arg Met Val Ser Glu Ala Gly Thr Gly Phe Cys Phe Asn Thr 
            20                  25                  30          


Lys Arg Asn Arg Leu Arg Glu Lys Leu Thr Leu Leu His Tyr Asp Pro 
        35                  40                  45              


Val Val Lys Gln Arg Val Leu Phe Val Glu Lys Lys Lys Ile Arg Ser 
    50                  55                  60                  


Leu 
65  


<210> 5161
<211> 972
<212> PRT
<213> Homo sapiens

<400> 5161
Met Arg Pro Glu Gly Ala Gly Met Glu Leu Gly Gly Gly Glu Glu Arg 
1               5                   10                  15      


Leu Pro Glu Glu Ser Arg Arg Glu His Trp Gln Leu Leu Gly Asn Leu 
            20                  25                  30          


Lys Thr Thr Val Glu Gly Leu Val Ser Thr Asn Ser Pro Asn Val Trp 
        35                  40                  45              


Ser Lys Tyr Gly Gly Leu Glu Arg Leu Cys Arg Asp Met Gln Ser Ile 
    50                  55                  60                  


Leu Tyr His Gly Leu Ile Arg Asp Gln Ala Cys Arg Arg Gln Thr Asp 
65                  70                  75                  80  


Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser Pro His Ser Ala 
                85                  90                  95      


Leu His Val Glu Lys Phe Ile Ser Val His Glu Asn Asp Gln Ser Ser 
            100                 105                 110         


Ala Asp Gly Ala Ser Glu Arg Ala Val Ala Glu Leu Trp Leu Gln His 
        115                 120                 125             


Ser Leu Gln Tyr His Cys Leu Ser Ala Gln Leu Arg Pro Leu Leu Gly 
    130                 135                 140                 


Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Asp Ala Ala Phe Leu Leu 
145                 150                 155                 160 


Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu Glu Ala Val Glu 
                165                 170                 175     


Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala Ser Met Phe Ala 
            180                 185                 190         


Arg Lys His Glu Ser Pro Leu Leu Val Thr Lys Ser Gln Ser Leu Thr 
        195                 200                 205             


Ala Leu Pro Ser Ser Thr Tyr Thr Pro Pro Asn Ser Tyr Ala Gln His 
    210                 215                 220                 


Ser Tyr Phe Gly Ser Phe Ser Ser Leu His Gln Ser Val Pro Asn Asn 
225                 230                 235                 240 


Gly Ser Glu Arg Arg Ser Thr Ser Phe Pro Leu Ser Gly Pro Pro Arg 
                245                 250                 255     


Lys Pro Gln Glu Ser Arg Gly His Val Ser Pro Ala Glu Asp Gln Thr 
            260                 265                 270         


Ile Gln Ala Pro Pro Val Ser Val Ser Ala Leu Ala Arg Asp Ser Pro 
        275                 280                 285             


Leu Thr Pro Asn Glu Met Ser Ser Ser Thr Leu Thr Ser Pro Ile Glu 
    290                 295                 300                 


Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Gly Asp Ala Ser Glu 
305                 310                 315                 320 


Gly Pro Glu Tyr Leu Ala Ile Gly Asn Leu Asp Pro Arg Gly Arg Thr 
                325                 330                 335     


Ala Ser Cys Gln Ser His Ser Ser Asn Ala Glu Ser Ser Ser Ser Asn 
            340                 345                 350         


Leu Phe Ser Ser Ser Ser Ser Gln Lys Pro Asp Ser Ala Ala Ser Ser 
        355                 360                 365             


Leu Gly Asp Gln Glu Gly Gly Gly Glu Ser Gln Leu Ser Ser Val Leu 
    370                 375                 380                 


Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Leu Thr Val Thr Ser Gly 
385                 390                 395                 400 


Ala Lys Lys Ser His Ile Arg Ser His Ser Asp Thr Ser Ile Ala Ser 
                405                 410                 415     


Arg Gly Ala Pro Glu Ser Cys Asn Asp Lys Ala Lys Leu Arg Gly Pro 
            420                 425                 430         


Leu Pro Tyr Ser Gly Gln Ser Ser Glu Val Ser Thr Pro Ser Ser Leu 
        435                 440                 445             


Tyr Met Glu Tyr Glu Gly Gly Arg Tyr Leu Cys Ser Gly Glu Gly Met 
    450                 455                 460                 


Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr Leu Ser Glu 
465                 470                 475                 480 


Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn Ala His Phe 
                485                 490                 495     


Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met Lys Cys Asn 
            500                 505                 510         


Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu Glu Asp Ser 
        515                 520                 525             


Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu Arg Arg Gln 
    530                 535                 540                 


Gln Ile Arg Thr Lys Asn Leu Leu Pro Met Tyr Gln Glu Ala Glu His 
545                 550                 555                 560 


Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser Ser Arg Asp 
                565                 570                 575     


Ser Ala Gln Leu Ser Asp Ser Gly Ser Ala Asp Glu Val Asp Glu Phe 
            580                 585                 590         


Glu Ile Gln Asp Ala Asp Ile Arg Arg Asn Thr Ala Ser Ser Ser Lys 
        595                 600                 605             


Ser Phe Val Ser Ser Gln Ser Phe Ser His Cys Phe Leu His Ser Thr 
    610                 615                 620                 


Ser Ala Glu Ala Val Ala Met Gly Leu Leu Lys Gln Phe Glu Gly Met 
625                 630                 635                 640 


Gln Leu Pro Ala Ala Ser Glu Leu Glu Trp Leu Val Pro Glu His Asp 
                645                 650                 655     


Ala Pro Gln Lys Leu Leu Pro Ile Pro Asp Ser Leu Pro Ile Ser Pro 
            660                 665                 670         


Asp Asp Gly Gln His Ala Asp Ile Tyr Lys Leu Arg Ile Arg Val Arg 
        675                 680                 685             


Gly Asn Leu Glu Trp Ala Pro Pro Arg Pro Gln Ile Ile Phe Asn Val 
    690                 695                 700                 


His Pro Ala Pro Thr Arg Lys Ile Ala Val Ala Lys Gln Asn Tyr Arg 
705                 710                 715                 720 


Cys Ala Gly Cys Gly Ile Arg Thr Asp Pro Asp Tyr Ile Lys Arg Leu 
                725                 730                 735     


Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Gln Cys Cys His Glu 
            740                 745                 750         


Asn Ala Gln Met Ala Ile Pro Ser Arg Val Leu Arg Lys Trp Asp Phe 
        755                 760                 765             


Ser Lys Tyr Tyr Val Ser Asn Phe Ser Lys Asp Leu Leu Ile Lys Ile 
    770                 775                 780                 


Trp Asn Asp Pro Leu Phe Asn Val Gln Asp Ile Asn Ser Ala Leu Tyr 
785                 790                 795                 800 


Arg Lys Val Lys Leu Leu Asn Gln Val Arg Leu Leu Arg Val Gln Leu 
                805                 810                 815     


Cys His Met Lys Asn Met Phe Lys Thr Cys Arg Leu Ala Lys Glu Leu 
            820                 825                 830         


Leu Asp Ser Phe Asp Thr Val Pro Gly His Leu Thr Glu Asp Leu His 
        835                 840                 845             


Leu Tyr Ser Leu Asn Asp Leu Thr Ala Thr Arg Lys Gly Glu Leu Gly 
    850                 855                 860                 


Pro Arg Leu Ala Glu Leu Thr Arg Ala Gly Ala Thr His Val Glu Arg 
865                 870                 875                 880 


Cys Met Leu Cys Gln Ala Lys Gly Phe Ile Cys Glu Phe Cys Gln Asn 
                885                 890                 895     


Glu Asp Asp Ile Ile Phe Pro Phe Glu Leu His Lys Cys Arg Thr Cys 
            900                 905                 910         


Glu Glu Cys Lys Ala Cys Tyr His Lys Ala Cys Phe Lys Ser Gly Ser 
        915                 920                 925             


Cys Pro Arg Cys Glu Arg Leu Gln Ala Arg Arg Glu Ala Leu Ala Arg 
    930                 935                 940                 


Gln Ser Leu Glu Ser Tyr Leu Ser Asp Tyr Glu Glu Glu Pro Ala Glu 
945                 950                 955                 960 


Ala Leu Ala Leu Glu Ala Ala Val Leu Glu Ala Thr 
                965                 970         


<210> 5162
<211> 386
<212> PRT
<213> Homo sapiens

<400> 5162
Met Ala Ala Val Glu Thr Arg Val Cys Glu Thr Asp Gly Cys Ser Ser 
1               5                   10                  15      


Glu Ala Lys Leu Gln Cys Pro Thr Cys Ile Lys Leu Gly Ile Gln Gly 
            20                  25                  30          


Ser Tyr Phe Cys Ser Gln Glu Cys Phe Lys Gly Ser Trp Ala Thr His 
        35                  40                  45              


Lys Leu Leu His Lys Lys Ala Lys Asp Glu Lys Ala Lys Arg Glu Val 
    50                  55                  60                  


Ser Ser Trp Thr Val Glu Gly Asp Ile Asn Thr Asp Pro Trp Ala Gly 
65                  70                  75                  80  


Tyr Arg Tyr Thr Gly Lys Leu Arg Pro His Tyr Pro Leu Met Pro Thr 
                85                  90                  95      


Arg Pro Val Pro Ser Tyr Ile Gln Arg Pro Asp Tyr Ala Asp His Pro 
            100                 105                 110         


Leu Gly Met Ser Glu Ser Glu Gln Ala Leu Lys Gly Thr Ser Gln Ile 
        115                 120                 125             


Lys Leu Leu Ser Ser Glu Asp Ile Glu Gly Met Arg Leu Val Cys Arg 
    130                 135                 140                 


Leu Ala Arg Glu Val Leu Asp Val Ala Ala Gly Met Ile Lys Pro Gly 
145                 150                 155                 160 


Val Thr Thr Glu Glu Ile Asp His Ala Val His Leu Ala Cys Ile Ala 
                165                 170                 175     


Arg Asn Cys Tyr Pro Ser Pro Leu Asn Tyr Tyr Asn Phe Pro Lys Ser 
            180                 185                 190         


Cys Cys Thr Ser Val Asn Glu Val Ile Cys His Gly Ile Pro Asp Arg 
        195                 200                 205             


Arg Pro Leu Gln Glu Gly Asp Ile Val Asn Val Asp Ile Thr Leu Tyr 
    210                 215                 220                 


Arg Asn Gly Tyr His Gly Asp Leu Asn Glu Thr Phe Phe Val Gly Glu 
225                 230                 235                 240 


Val Asp Asp Gly Ala Arg Lys Leu Val Gln Thr Thr Tyr Glu Cys Leu 
                245                 250                 255     


Met Gln Ala Ile Asp Ala Val Lys Pro Gly Val Arg Tyr Arg Glu Leu 
            260                 265                 270         


Gly Asn Ile Ile Gln Lys His Ala Gln Ala Asn Gly Phe Ser Val Val 
        275                 280                 285             


Arg Ser Tyr Cys Gly His Gly Ile His Lys Leu Phe His Thr Ala Pro 
    290                 295                 300                 


Asn Val Pro His Tyr Ala Lys Asn Lys Ala Val Gly Val Met Lys Ser 
305                 310                 315                 320 


Gly His Val Phe Thr Ile Glu Pro Met Ile Cys Glu Gly Gly Trp Gln 
                325                 330                 335     


Asp Glu Thr Trp Pro Asp Gly Trp Thr Ala Val Thr Arg Asp Gly Lys 
            340                 345                 350         


Arg Ser Ala Gln Phe Glu His Thr Leu Leu Val Thr Asp Thr Gly Cys 
        355                 360                 365             


Glu Ile Leu Thr Arg Arg Leu Asp Ser Ala Arg Pro His Phe Met Ser 
    370                 375                 380                 


Gln Phe 
385     


<210> 5163
<211> 245
<212> PRT
<213> Homo sapiens

<400> 5163
Met Gly Arg Leu Asp Gly Lys Val Ile Ile Leu Thr Ala Ala Ala Gln 
1               5                   10                  15      


Gly Ile Gly Gln Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Ala Thr Asp Ile Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys 
        35                  40                  45              


Tyr Pro Gly Ile Gln Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gln 
    50                  55                  60                  


Ile Asp Gln Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn 
65                  70                  75                  80  


Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys 
                85                  90                  95      


Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met 
            100                 105                 110         


Ile Lys Ala Phe Leu Pro Lys Met Leu Ala Gln Lys Ser Gly Asn Ile 
        115                 120                 125             


Ile Asn Met Ser Ser Val Ala Ser Ser Val Lys Gly Val Val Asn Arg 
    130                 135                 140                 


Cys Val Tyr Ser Thr Thr Lys Ala Ala Val Ile Gly Leu Thr Lys Ser 
145                 150                 155                 160 


Val Ala Ala Asp Phe Ile Gln Gln Gly Ile Arg Cys Asn Cys Val Cys 
                165                 170                 175     


Pro Gly Thr Val Asp Thr Pro Ser Leu Gln Glu Arg Ile Gln Ala Arg 
            180                 185                 190         


Gly Asn Pro Glu Glu Ala Arg Asn Asp Phe Leu Lys Arg Gln Lys Thr 
        195                 200                 205             


Gly Arg Phe Ala Thr Ala Glu Glu Ile Ala Met Leu Cys Val Tyr Leu 
    210                 215                 220                 


Ala Ser Asp Glu Ser Ala Tyr Val Thr Gly Asn Pro Val Ile Ile Asp 
225                 230                 235                 240 


Gly Gly Trp Ser Leu 
                245 


<210> 5164
<211> 839
<212> PRT
<213> Homo sapiens

<400> 5164
Met Ser Val Val Gly Ile Asp Leu Gly Phe Leu Asn Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ser Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ala Cys Ile Ser Leu Gly Ser Arg Thr Arg Ala Ile 
        35                  40                  45              


Gly Asn Ala Ala Lys Ser Gln Ile Val Thr Asn Val Arg Asn Thr Ile 
    50                  55                  60                  


His Gly Phe Lys Lys Leu His Gly Arg Ser Phe Asp Asp Pro Ile Val 
65                  70                  75                  80  


Gln Thr Glu Arg Ile Arg Leu Pro Tyr Glu Leu Gln Lys Met Pro Asn 
                85                  90                  95      


Gly Ser Ala Gly Val Lys Val Arg Tyr Leu Glu Glu Glu Arg Pro Phe 
            100                 105                 110         


Ala Ile Glu Gln Val Thr Gly Met Leu Leu Ala Lys Leu Lys Glu Thr 
        115                 120                 125             


Ser Glu Asn Ala Leu Lys Lys Pro Val Ala Asp Cys Val Ile Ser Ile 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Met Ala Ala Ala 
145                 150                 155                 160 


Gln Val Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                165                 170                 175     


Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Pro Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Asn Val Val Phe Ile Asp Met Gly His Ser Ala Tyr 
        195                 200                 205             


Gln Val Leu Val Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Ala 
    210                 215                 220                 


Thr Thr Phe Asp Pro Tyr Leu Gly Gly Arg Asn Phe Asp Glu Ala Leu 
225                 230                 235                 240 


Val Asp Tyr Phe Cys Asp Glu Phe Lys Thr Lys Tyr Lys Ile Asn Val 
                245                 250                 255     


Lys Glu Asn Ser Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Leu Asp Val Ser Ser Lys Met Asn Arg Ala 
    290                 295                 300                 


Gln Phe Glu Gln Leu Cys Ala Ser Leu Leu Ala Arg Val Glu Pro Pro 
305                 310                 315                 320 


Leu Lys Ala Val Met Glu Gln Ala Asn Leu Gln Arg Glu Asp Ile Ser 
                325                 330                 335     


Ser Ile Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Gln Ile Thr Lys Phe Phe Leu Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Leu Val Pro Tyr 
385                 390                 395                 400 


Ser Ile Thr Leu Arg Trp Lys Thr Ser Phe Glu Asp Gly Ser Gly Glu 
                405                 410                 415     


Cys Glu Val Phe Cys Lys Asn His Pro Ala Pro Phe Ser Lys Val Ile 
            420                 425                 430         


Thr Phe His Lys Lys Glu Pro Phe Glu Leu Glu Ala Phe Tyr Thr Asn 
        435                 440                 445             


Leu His Glu Val Pro Tyr Pro Asp Ala Arg Ile Gly Ser Phe Thr Ile 
    450                 455                 460                 


Gln Asn Val Phe Pro Gln Ser Asp Gly Asp Ser Ser Lys Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Ile His Gly Ile Phe Ser Val Ala Ser Ala Ser 
                485                 490                 495     


Val Ile Glu Lys Gln Asn Leu Glu Gly Asp His Ser Asp Ala Pro Met 
            500                 505                 510         


Glu Thr Glu Thr Ser Phe Lys Asn Glu Asn Lys Asp Asn Met Asp Lys 
        515                 520                 525             


Met Gln Val Asp Gln Glu Glu Gly His Gln Lys Cys His Ala Glu His 
    530                 535                 540                 


Thr Pro Glu Glu Glu Ile Asp His Thr Gly Ala Lys Thr Lys Ser Ala 
545                 550                 555                 560 


Val Ser Asp Lys Gln Asp Arg Leu Asn Gln Thr Leu Lys Lys Gly Lys 
                565                 570                 575     


Val Lys Ser Ile Asp Leu Pro Ile Gln Ser Ser Leu Cys Arg Gln Leu 
            580                 585                 590         


Gly Gln Asp Leu Leu Asn Ser Tyr Ile Glu Asn Glu Gly Lys Met Ile 
        595                 600                 605             


Met Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val 
    610                 615                 620                 


Glu Glu Tyr Val Tyr Asp Phe Arg Asp Arg Leu Gly Thr Val Tyr Glu 
625                 630                 635                 640 


Lys Phe Ile Thr Pro Glu Asp Leu Ser Lys Leu Ser Ala Val Leu Glu 
                645                 650                 655     


Asp Thr Glu Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln 
            660                 665                 670         


Val Tyr Val Asp Lys Leu Gln Glu Leu Lys Lys Tyr Gly Gln Pro Ile 
        675                 680                 685             


Gln Met Lys Tyr Met Glu His Glu Glu Arg Pro Lys Ala Leu Asn Asp 
    690                 695                 700                 


Leu Gly Lys Lys Ile Gln Leu Val Met Lys Val Ile Glu Ala Tyr Arg 
705                 710                 715                 720 


Asn Lys Asp Glu Arg Tyr Asp His Leu Asp Pro Thr Glu Met Glu Lys 
                725                 730                 735     


Val Glu Lys Cys Ile Ser Asp Ala Met Ser Trp Leu Asn Ser Lys Met 
            740                 745                 750         


Asn Ala Gln Asn Lys Leu Ser Leu Thr Gln Asp Pro Val Val Lys Val 
        755                 760                 765             


Ser Glu Ile Val Ala Lys Ser Lys Glu Leu Asp Asn Phe Cys Asn Pro 
    770                 775                 780                 


Ile Ile Tyr Lys Pro Lys Pro Lys Ala Glu Val Pro Glu Asp Lys Pro 
785                 790                 795                 800 


Lys Ala Asn Ser Glu His Asn Gly Pro Met Asp Gly Gln Ser Gly Thr 
                805                 810                 815     


Glu Thr Lys Ser Asp Ser Thr Lys Asp Ser Ser Gln His Thr Lys Ser 
            820                 825                 830         


Ser Gly Glu Met Glu Val Asp 
        835                 


<210> 5165
<211> 407
<212> PRT
<213> Homo sapiens

<400> 5165
Met Ala Ala Pro Cys Ala Glu Asp Pro Ser Leu Glu Arg His Phe Lys 
1               5                   10                  15      


Gly His Arg Asp Ala Val Thr Cys Val Asp Phe Ser Ile Asn Thr Lys 
            20                  25                  30          


Gln Leu Ala Ser Gly Ser Met Asp Ser Cys Leu Met Val Trp His Met 
        35                  40                  45              


Lys Pro Gln Ser Arg Ala Tyr Arg Phe Thr Gly His Lys Asp Ala Val 
    50                  55                  60                  


Thr Cys Val Asn Phe Ser Pro Ser Gly His Leu Leu Ala Ser Gly Ser 
65                  70                  75                  80  


Arg Asp Lys Thr Val Arg Ile Trp Val Pro Asn Val Lys Gly Glu Ser 
                85                  90                  95      


Thr Val Phe Arg Ala His Thr Ala Thr Val Arg Ser Val His Phe Cys 
            100                 105                 110         


Ser Asp Gly Gln Ser Phe Val Thr Ala Ser Asp Asp Lys Thr Val Lys 
        115                 120                 125             


Val Trp Ala Thr His Arg Gln Lys Phe Leu Phe Ser Leu Ser Gln His 
    130                 135                 140                 


Ile Asn Trp Val Arg Cys Ala Lys Phe Ser Pro Asp Gly Arg Leu Ile 
145                 150                 155                 160 


Val Ser Ala Ser Asp Asp Lys Thr Val Lys Leu Trp Asp Lys Ser Ser 
                165                 170                 175     


Arg Glu Cys Val His Ser Tyr Cys Glu His Gly Gly Phe Val Thr Tyr 
            180                 185                 190         


Val Asp Phe His Pro Ser Gly Thr Cys Ile Ala Ala Ala Gly Met Asp 
        195                 200                 205             


Asn Thr Val Lys Val Trp Asp Val Arg Thr His Arg Leu Leu Gln His 
    210                 215                 220                 


Tyr Gln Leu His Ser Ala Ala Val Asn Gly Leu Ser Phe His Pro Ser 
225                 230                 235                 240 


Gly Asn Tyr Leu Ile Thr Ala Ser Ser Asp Ser Thr Leu Lys Ile Leu 
                245                 250                 255     


Asp Leu Met Glu Gly Arg Leu Leu Tyr Thr Leu His Gly His Gln Gly 
            260                 265                 270         


Pro Ala Thr Thr Val Ala Phe Ser Arg Thr Gly Glu Tyr Phe Ala Ser 
        275                 280                 285             


Gly Gly Ser Asp Glu Gln Val Met Val Trp Lys Ser Asn Phe Asp Ile 
    290                 295                 300                 


Val Asp His Gly Glu Val Thr Lys Val Pro Arg Pro Pro Ala Thr Leu 
305                 310                 315                 320 


Ala Ser Ser Met Gly Asn Leu Pro Glu Val Asp Phe Pro Val Pro Pro 
                325                 330                 335     


Gly Arg Gly Arg Ser Val Glu Ser Val Gln Ser Gln Pro Gln Glu Pro 
            340                 345                 350         


Val Ser Val Pro Gln Thr Leu Thr Ser Thr Leu Glu His Ile Val Gly 
        355                 360                 365             


Gln Leu Asp Val Leu Thr Gln Thr Val Ser Ile Leu Glu Gln Arg Leu 
    370                 375                 380                 


Thr Leu Thr Glu Asp Lys Leu Lys Gln Cys Leu Glu Asn Gln Gln Leu 
385                 390                 395                 400 


Ile Met Gln Arg Ala Thr Pro 
                405         


<210> 5166
<211> 390
<212> PRT
<213> Homo sapiens

<400> 5166
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


Leu Asn Cys Val Met Lys Lys His Lys Glu Leu Ser Ser Leu Gln Lys 
        115                 120                 125             


Ile Pro Ser Gln Gln Arg Lys Lys Ile Ser Ser Gly Lys Ser Glu Pro 
    130                 135                 140                 


Pro Leu Gly Asn Glu Lys Ile Ser Ala Glu Ala Val Gly Val Asp Ile 
145                 150                 155                 160 


Ser Gly Arg Phe Met Thr Ser Gly Lys Lys Lys Ala Val Val Ile Arg 
                165                 170                 175     


His Leu Tyr Asn Glu Asp Asn Val Asp Ile Ser Glu Asp Thr Leu Ser 
            180                 185                 190         


Pro Ile Thr Asp Val Asn Glu Ala Val Asp Val Ser Asp Leu Asn Ala 
        195                 200                 205             


Thr Glu Ile Lys Met Pro Glu Val Lys Val Pro Glu Ile Lys Ala Glu 
    210                 215                 220                 


Gln Gln Asp Val Asn Val Asn Pro Glu Ile Thr Ala Leu Gln Thr Met 
225                 230                 235                 240 


Leu Ala Glu Cys Gln Glu Asn Leu Lys Lys Leu Thr Ser Ile Glu Lys 
                245                 250                 255     


Arg Leu Asp Cys Leu Glu Gln Lys Met Lys Gly Lys Val Met Val Asp 
            260                 265                 270         


Glu Asn Thr Trp Thr Asn Leu Leu Ser Arg Val Thr Leu Leu Glu Thr 
        275                 280                 285             


Glu Met Leu Leu Ser Lys Lys Asn Asp Glu Phe Ile Glu Phe Asn Glu 
    290                 295                 300                 


Val Ser Glu Asp Tyr Ala Ser Cys Ser Asp Met Asp Leu Leu Asn Pro 
305                 310                 315                 320 


His Arg Lys Ser Glu Val Glu Arg Pro Ala Ser Ile Pro Leu Ser Ser 
                325                 330                 335     


Gly Tyr Ser Thr Ala Ser Ser Asp Ser Thr Pro Arg Ala Ser Thr Val 
            340                 345                 350         


Asn Tyr Cys Gly Leu Asn Glu Ile Ser Glu Glu Thr Thr Ile Gln Lys 
        355                 360                 365             


Met Glu Arg Met Lys Lys Met Phe Glu Glu Thr Ala Glu Leu Leu Lys 
    370                 375                 380                 


Cys Pro Asn His Tyr Leu 
385                 390 


<210> 5167
<211> 866
<212> PRT
<213> Homo sapiens

<400> 5167
Met Pro Ala Val Ser Leu Pro Pro Lys Glu Asn Ala Leu Phe Lys Arg 
1               5                   10                  15      


Ile Leu Arg Cys Tyr Glu His Lys Gln Tyr Arg Asn Gly Leu Lys Phe 
            20                  25                  30          


Cys Lys Gln Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr 
        35                  40                  45              


Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu 
    50                  55                  60                  


Ala Tyr Glu Leu Val Arg Arg Gly Leu Arg Asn Asp Leu Lys Ser His 
65                  70                  75                  80  


Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr 
                85                  90                  95      


Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Trp Asp Lys Asp 
            100                 105                 110         


Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg 
        115                 120                 125             


Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg 
    130                 135                 140                 


Pro Ala Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu 
145                 150                 155                 160 


Leu Glu Asp Tyr Glu Met Ala Ala Lys Ile Leu Glu Glu Phe Arg Lys 
                165                 170                 175     


Thr Gln Gln Thr Ser Pro Asp Lys Val Asp Tyr Glu Tyr Ser Glu Leu 
            180                 185                 190         


Leu Leu Tyr Gln Asn Gln Val Leu Arg Glu Ala Gly Leu Tyr Arg Glu 
        195                 200                 205             


Ala Leu Glu His Leu Cys Thr Tyr Glu Lys Gln Ile Cys Asp Lys Leu 
    210                 215                 220                 


Ala Val Glu Glu Thr Lys Gly Glu Leu Leu Leu Gln Leu Cys Arg Leu 
225                 230                 235                 240 


Glu Asp Ala Ala Asp Val Tyr Arg Gly Leu Gln Glu Arg Asn Pro Glu 
                245                 250                 255     


Asn Trp Ala Tyr Tyr Lys Gly Leu Glu Lys Ala Leu Lys Pro Ala Asn 
            260                 265                 270         


Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys Tyr Pro 
        275                 280                 285             


Arg Gly Leu Val Pro Arg Arg Leu Pro Leu Asn Phe Leu Ser Gly Glu 
    290                 295                 300                 


Lys Phe Lys Glu Cys Leu Asp Lys Phe Leu Arg Met Asn Phe Ser Lys 
305                 310                 315                 320 


Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Lys Asp Lys 
                325                 330                 335     


Glu Lys Val Ala Ile Ile Glu Glu Leu Val Val Gly Tyr Glu Thr Ser 
            340                 345                 350         


Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys Glu Glu 
        355                 360                 365             


Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln His Tyr 
    370                 375                 380                 


Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn Thr Ala 
385                 390                 395                 400 


Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys Ala Lys 
                405                 410                 415     


Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp Met Asp 
            420                 425                 430         


Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
        435                 440                 445             


Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu Glu Met 
    450                 455                 460                 


Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn Leu Asn 
465                 470                 475                 480 


Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala Tyr Lys 
                485                 490                 495     


Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu Ile Glu 
            500                 505                 510         


Arg His Phe Ile Glu Ile Thr Asp Asp Gln Phe Asp Phe His Thr Tyr 
        515                 520                 525             


Cys Met Arg Lys Ile Thr Leu Arg Ser Tyr Val Asp Leu Leu Lys Leu 
    530                 535                 540                 


Glu Asp Val Leu Arg Gln His Pro Phe Tyr Phe Lys Ala Ala Arg Ile 
545                 550                 555                 560 


Ala Ile Glu Ile Tyr Leu Lys Leu His Asp Asn Pro Leu Thr Asp Glu 
                565                 570                 575     


Asn Lys Glu His Glu Ala Asp Thr Ala Asn Met Ser Asp Lys Glu Leu 
            580                 585                 590         


Lys Lys Leu Arg Asn Lys Gln Arg Arg Ala Gln Lys Lys Ala Gln Ile 
        595                 600                 605             


Glu Glu Glu Lys Lys Asn Ala Glu Lys Glu Lys Gln Gln Arg Asn Gln 
    610                 615                 620                 


Lys Lys Lys Lys Asp Asp Asp Asp Glu Glu Ile Gly Gly Pro Lys Glu 
625                 630                 635                 640 


Glu Leu Ile Pro Glu Lys Leu Ala Lys Val Glu Thr Pro Leu Glu Glu 
                645                 650                 655     


Ala Ile Lys Phe Leu Thr Pro Leu Lys Asn Leu Val Lys Asn Lys Ile 
            660                 665                 670         


Glu Thr His Leu Phe Ala Phe Glu Ile Tyr Phe Arg Lys Glu Lys Phe 
        675                 680                 685             


Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asp Ser Ser 
    690                 695                 700                 


His Pro Trp Leu His Glu Cys Met Ile Arg Leu Phe Asn Thr Ala Val 
705                 710                 715                 720 


Cys Glu Ser Lys Asp Leu Ser Asp Thr Val Arg Thr Val Leu Lys Gln 
                725                 730                 735     


Glu Met Asn Arg Leu Phe Gly Ala Thr Asn Pro Lys Asn Phe Asn Glu 
            740                 745                 750         


Thr Phe Leu Lys Arg Asn Ser Asp Ser Leu Pro His Arg Leu Ser Ala 
        755                 760                 765             


Ala Lys Met Val Tyr Tyr Leu Asp Pro Ser Ser Gln Lys Arg Ala Ile 
    770                 775                 780                 


Glu Leu Ala Thr Thr Leu Asp Glu Ser Leu Thr Asn Arg Asn Leu Gln 
785                 790                 795                 800 


Thr Cys Met Glu Val Leu Glu Ala Leu Tyr Asp Gly Ser Leu Gly Asp 
                805                 810                 815     


Cys Lys Glu Ala Ala Glu Ile Tyr Arg Ala Asn Cys His Lys Leu Phe 
            820                 825                 830         


Pro Tyr Ala Leu Ala Phe Met Pro Pro Gly Tyr Glu Glu Asp Met Lys 
        835                 840                 845             


Ile Thr Val Asn Gly Asp Ser Ser Ala Glu Ala Glu Glu Leu Ala Asn 
    850                 855                 860                 


Glu Ile 
865     


<210> 5168
<211> 430
<212> PRT
<213> Homo sapiens

<400> 5168
Met Ala Ser Ser Ala Lys Ser Ala Glu Met Pro Thr Ile Ser Lys Thr 
1               5                   10                  15      


Val Asn Pro Thr Pro Asp Pro His Gln Glu Tyr Leu Asp Pro Arg Ile 
            20                  25                  30          


Thr Ile Ala Leu Phe Glu Ile Gly Ser His Ser Pro Ser Ser Trp Gly 
        35                  40                  45              


Ser Leu Pro Phe Leu Lys Asn Ser Ser His Gln Val Thr Glu Gln Gln 
    50                  55                  60                  


Thr Ala Gln Lys Phe Asn Asn Leu Leu Lys Glu Ile Lys Asp Ile Leu 
65                  70                  75                  80  


Lys Asn Met Ala Gly Phe Glu Glu Lys Ile Thr Glu Ala Lys Glu Leu 
                85                  90                  95      


Phe Glu Glu Thr Asn Ile Thr Glu Asp Val Ser Ala His Lys Glu Asn 
            100                 105                 110         


Ile Arg Gly Leu Asp Lys Ile Asn Glu Met Leu Ser Thr Asn Leu Pro 
        115                 120                 125             


Val Ser Leu Ala Pro Glu Lys Glu Asp Asn Glu Lys Lys Gln Glu Met 
    130                 135                 140                 


Ile Leu Glu Thr Asn Ile Thr Glu Asp Val Ser Ala His Lys Glu Asn 
145                 150                 155                 160 


Ile Arg Gly Leu Asp Lys Ile Asn Glu Met Leu Ser Thr Asn Leu Pro 
                165                 170                 175     


Val Ser Leu Ala Pro Glu Lys Glu Asp Asn Glu Lys Lys Gln Gln Met 
            180                 185                 190         


Ile Met Glu Asn Gln Asn Ser Glu Asn Thr Ala Gln Val Phe Ala Arg 
        195                 200                 205             


Asp Leu Val Asn Arg Leu Glu Glu Lys Lys Val Leu Asn Glu Thr Gln 
    210                 215                 220                 


Gln Ser Gln Glu Lys Ala Lys Asn Arg Leu Asn Val Gln Glu Glu Thr 
225                 230                 235                 240 


Met Lys Ile Arg Asn Asn Met Glu Gln Leu Leu Gln Glu Ala Glu His 
                245                 250                 255     


Trp Ser Lys Gln His Thr Glu Leu Ser Lys Leu Ile Lys Ser Tyr Gln 
            260                 265                 270         


Lys Ser Gln Lys Asp Ile Ser Glu Thr Leu Gly Asn Asn Gly Val Gly 
        275                 280                 285             


Phe Gln Thr Gln Pro Asn Asn Glu Val Ser Ala Lys His Glu Leu Glu 
    290                 295                 300                 


Glu Gln Val Lys Lys Leu Ser His Asp Thr Tyr Ser Leu Gln Leu Met 
305                 310                 315                 320 


Ala Ala Leu Leu Glu Asn Glu Cys Gln Ile Leu Gln Gln Arg Val Glu 
                325                 330                 335     


Ile Leu Lys Glu Leu His His Gln Lys Gln Gly Thr Leu Gln Glu Lys 
            340                 345                 350         


Pro Ile Gln Ile Asn Tyr Lys Gln Asp Lys Lys Asn Gln Lys Pro Ser 
        355                 360                 365             


Glu Ala Lys Lys Val Glu Met Tyr Lys Gln Asn Lys Gln Ala Met Lys 
    370                 375                 380                 


Gly Thr Phe Trp Lys Lys Asp Arg Ser Cys Arg Ser Leu Asp Val Cys 
385                 390                 395                 400 


Leu Asn Lys Lys Ala Cys Asn Thr Gln Phe Asn Ile His Val Ala Arg 
                405                 410                 415     


Lys Ala Leu Arg Gly Lys Met Arg Ser Ala Ser Ser Leu Arg 
            420                 425                 430 


<210> 5169
<211> 1732
<212> PRT
<213> Homo sapiens

<400> 5169
Met Ala Ala Ile Gly Arg Gly Arg Ser Leu Lys Asn Leu Arg Val Arg 
1               5                   10                  15      


Gly Arg Asn Asp Ser Gly Glu Glu Asn Val Pro Leu Asp Leu Thr Arg 
            20                  25                  30          


Glu Pro Ser Asp Asn Leu Arg Glu Ile Leu Gln Asn Val Ala Arg Leu 
        35                  40                  45              


Gln Gly Val Ser Asn Met Arg Lys Leu Gly His Leu Asn Asn Phe Thr 
    50                  55                  60                  


Lys Leu Leu Cys Asp Ile Gly His Ser Glu Glu Lys Leu Gly Phe His 
65                  70                  75                  80  


Tyr Glu Asp Ile Ile Ile Cys Leu Arg Leu Ala Leu Leu Asn Glu Ala 
                85                  90                  95      


Lys Glu Val Arg Ala Ala Gly Leu Arg Ala Leu Arg Tyr Leu Ile Gln 
            100                 105                 110         


Asp Ser Ser Ile Leu Gln Lys Val Leu Lys Leu Lys Val Asp Tyr Leu 
        115                 120                 125             


Ile Ala Arg Cys Ile Asp Ile Gln Gln Ser Asn Glu Val Glu Arg Thr 
    130                 135                 140                 


Gln Ala Leu Arg Leu Val Arg Lys Met Ile Thr Val Asn Ala Ser Leu 
145                 150                 155                 160 


Phe Pro Ser Ser Val Thr Asn Ser Leu Ile Ala Val Gly Asn Asp Gly 
                165                 170                 175     


Leu Gln Glu Arg Asp Arg Met Val Arg Ala Cys Ile Ala Ile Ile Cys 
            180                 185                 190         


Glu Leu Ala Leu Gln Asn Pro Glu Val Val Ala Leu Arg Gly Gly Leu 
        195                 200                 205             


Asn Thr Ile Leu Lys Asn Val Ile Asp Cys Gln Leu Ser Arg Ile Asn 
    210                 215                 220                 


Glu Ala Leu Ile Thr Thr Ile Leu His Leu Leu Asn His Pro Lys Thr 
225                 230                 235                 240 


Arg Gln Tyr Val Arg Ala Asp Val Glu Leu Glu Arg Ile Leu Ala Pro 
                245                 250                 255     


Tyr Thr Asp Phe His Tyr Arg His Ser Pro Asp Thr Ala Glu Gly Gln 
            260                 265                 270         


Leu Lys Glu Asp Arg Glu Ala Arg Phe Leu Ala Ser Lys Met Gly Ile 
        275                 280                 285             


Ile Ala Thr Phe Arg Ser Trp Ala Gly Ile Ile Asn Leu Cys Lys Pro 
    290                 295                 300                 


Gly Asn Ser Gly Ile Gln Ser Leu Ile Gly Val Leu Cys Ile Pro Asn 
305                 310                 315                 320 


Met Glu Ile Arg Arg Gly Leu Leu Glu Val Leu Tyr Asp Ile Phe Arg 
                325                 330                 335     


Leu Pro Leu Pro Val Val Thr Glu Glu Phe Ile Glu Ala Leu Leu Ser 
            340                 345                 350         


Val Asp Pro Gly Arg Phe Gln Asp Ser Trp Arg Leu Ser Asp Gly Phe 
        355                 360                 365             


Val Ala Ala Glu Ala Lys Thr Ile Leu Pro His Arg Ala Arg Ser Arg 
    370                 375                 380                 


Pro Asp Leu Met Asp Asn Tyr Leu Ala Leu Ile Leu Ser Ala Phe Ile 
385                 390                 395                 400 


Arg Asn Gly Leu Leu Glu Gly Leu Val Glu Val Ile Thr Asn Ser Asp 
                405                 410                 415     


Asp His Ile Ser Val Arg Ala Thr Ile Leu Leu Gly Glu Leu Leu His 
            420                 425                 430         


Met Ala Asn Thr Ile Leu Pro His Ser His Ser His His Leu His Cys 
        435                 440                 445             


Leu Pro Thr Leu Met Asn Met Ala Ala Ser Phe Asp Ile Pro Lys Glu 
    450                 455                 460                 


Lys Arg Leu Arg Ala Ser Ala Ala Leu Asn Cys Leu Lys Arg Phe His 
465                 470                 475                 480 


Glu Met Lys Lys Arg Gly Pro Lys Pro Tyr Ser Leu His Leu Asp His 
                485                 490                 495     


Ile Ile Gln Lys Ala Ile Ala Thr His Gln Lys Arg Asp Gln Tyr Leu 
            500                 505                 510         


Arg Val Gln Lys Asp Ile Phe Ile Leu Lys Asp Thr Glu Glu Ala Leu 
        515                 520                 525             


Leu Ile Asn Leu Arg Asp Ser Gln Val Leu Gln His Lys Glu Asn Leu 
    530                 535                 540                 


Glu Trp Asn Trp Asn Leu Ile Gly Thr Ile Leu Lys Trp Pro Asn Val 
545                 550                 555                 560 


Asn Leu Arg Asn Tyr Lys Asp Glu Gln Leu His Arg Phe Val Arg Arg 
                565                 570                 575     


Leu Leu Tyr Phe Tyr Lys Pro Ser Ser Lys Leu Tyr Ala Asn Leu Asp 
            580                 585                 590         


Leu Asp Phe Ala Lys Ala Lys Gln Leu Thr Val Val Gly Cys Gln Phe 
        595                 600                 605             


Thr Glu Phe Leu Leu Glu Ser Glu Glu Asp Gly Gln Gly Tyr Leu Glu 
    610                 615                 620                 


Asp Leu Val Lys Asp Ile Val Gln Trp Leu Asn Ala Ser Ser Gly Met 
625                 630                 635                 640 


Lys Pro Glu Arg Ser Leu Gln Asn Asn Gly Leu Leu Thr Thr Leu Ser 
                645                 650                 655     


Gln His Tyr Phe Leu Phe Ile Gly Thr Leu Ser Cys His Pro His Gly 
            660                 665                 670         


Val Lys Met Leu Glu Lys Cys Ser Val Phe Gln Cys Leu Leu Asn Leu 
        675                 680                 685             


Cys Ser Leu Lys Asn Gln Asp His Leu Leu Lys Leu Thr Val Ser Ser 
    690                 695                 700                 


Leu Asp Tyr Ser Arg Asp Gly Leu Ala Arg Val Ile Leu Ser Lys Ile 
705                 710                 715                 720 


Leu Thr Ala Ala Thr Asp Ala Cys Arg Leu Tyr Ala Thr Lys His Leu 
                725                 730                 735     


Arg Val Leu Leu Arg Ala Asn Val Glu Phe Phe Asn Asn Trp Gly Ile 
            740                 745                 750         


Glu Leu Leu Val Thr Gln Leu His Asp Lys Asn Lys Thr Ile Ser Ser 
        755                 760                 765             


Glu Ala Leu Asp Ile Leu Asp Glu Ala Cys Glu Asp Lys Ala Asn Leu 
    770                 775                 780                 


His Ala Leu Ile Gln Met Lys Pro Ala Leu Ser His Leu Gly Asp Lys 
785                 790                 795                 800 


Gly Leu Leu Leu Leu Leu Arg Phe Leu Ser Ile Pro Lys Gly Phe Ser 
                805                 810                 815     


Tyr Leu Asn Glu Arg Gly Tyr Val Ala Lys Gln Leu Glu Lys Trp His 
            820                 825                 830         


Arg Glu Tyr Asn Ser Lys Tyr Val Asp Leu Ile Glu Glu Gln Leu Asn 
        835                 840                 845             


Glu Ala Leu Thr Thr Tyr Arg Lys Pro Val Asp Gly Asp Asn Tyr Val 
    850                 855                 860                 


Arg Arg Ser Asn Gln Arg Leu Gln Arg Pro His Val Tyr Leu Pro Ile 
865                 870                 875                 880 


His Leu Tyr Gly Gln Leu Val His His Lys Thr Gly Cys His Leu Leu 
                885                 890                 895     


Glu Val Gln Asn Ile Ile Thr Glu Leu Cys Arg Asn Val Arg Thr Pro 
            900                 905                 910         


Asp Leu Asp Lys Trp Glu Glu Ile Lys Lys Leu Lys Ala Ser Leu Trp 
        915                 920                 925             


Ala Leu Gly Asn Ile Gly Ser Ser Asn Trp Gly Leu Asn Leu Leu Gln 
    930                 935                 940                 


Glu Glu Asn Val Ile Pro Asp Ile Leu Lys Leu Ala Lys Gln Cys Glu 
945                 950                 955                 960 


Val Leu Ser Ile Arg Gly Thr Cys Val Tyr Val Leu Gly Leu Ile Ala 
                965                 970                 975     


Lys Thr Lys Gln Gly Cys Asp Ile Leu Lys Cys His Asn Trp Asp Ala 
            980                 985                 990         


Val Arg His Ser Arg Lys His Leu  Trp Pro Val Val Pro  Asp Asp Val 
        995                 1000                 1005             


Glu Gln  Leu Cys Asn Glu Leu  Ser Ser Ile Pro Ser  Thr Leu Ser 
    1010                 1015                 1020             


Leu Asn  Ser Glu Ser Thr Ser  Ser Arg His Asn Ser  Glu Ser Glu 
    1025                 1030                 1035             


Ser Val  Pro Ser Ser Met Phe  Ile Leu Glu Asp Asp  Arg Phe Gly 
    1040                 1045                 1050             


Ser Ser  Ser Thr Ser Thr Phe  Phe Leu Asp Ile Asn  Glu Asp Thr 
    1055                 1060                 1065             


Glu Pro  Thr Phe Tyr Asp Arg  Ser Gly Pro Ile Lys  Asp Lys Asn 
    1070                 1075                 1080             


Ser Phe  Pro Phe Phe Ala Ser  Ser Lys Leu Val Lys  Asn Arg Ile 
    1085                 1090                 1095             


Leu Asn  Ser Leu Thr Leu Pro  Asn Lys Lys His Arg  Ser Ser Ser 
    1100                 1105                 1110             


Asp Pro  Lys Gly Gly Lys Leu  Ser Ser Glu Ser Lys  Thr Ser Asn 
    1115                 1120                 1125             


Arg Arg  Ile Arg Thr Leu Thr  Glu Pro Ser Val Asp  Phe Asn His 
    1130                 1135                 1140             


Ser Asp  Asp Phe Thr Pro Ile  Ser Thr Val Gln Lys  Thr Leu Gln 
    1145                 1150                 1155             


Leu Glu  Thr Ser Phe Met Gly  Asn Lys His Ile Glu  Asp Thr Gly 
    1160                 1165                 1170             


Ser Thr  Pro Ser Ile Gly Glu  Asn Asp Leu Lys Phe  Thr Lys Asn 
    1175                 1180                 1185             


Phe Gly  Thr Glu Asn His Arg  Glu Asn Thr Ser Arg  Glu Arg Leu 
    1190                 1195                 1200             


Val Val  Glu Ser Ser Thr Ser  Ser His Met Lys Ile  Arg Ser Gln 
    1205                 1210                 1215             


Ser Phe  Asn Thr Asp Thr Thr  Thr Ser Gly Ile Ser  Ser Met Ser 
    1220                 1225                 1230             


Ser Ser  Pro Ser Arg Glu Thr  Val Gly Val Asp Ala  Thr Thr Met 
    1235                 1240                 1245             


Asp Thr  Asp Cys Gly Ser Met  Ser Thr Val Val Ser  Thr Lys Thr 
    1250                 1255                 1260             


Ile Lys  Thr Ser His Tyr Leu  Thr Pro Gln Ser Asn  His Leu Ser 
    1265                 1270                 1275             


Leu Ser  Lys Ser Asn Ser Val  Ser Leu Val Pro Pro  Gly Ser Ser 
    1280                 1285                 1290             


His Thr  Leu Pro Arg Arg Ala  Gln Ser Leu Lys Ala  Pro Ser Ile 
    1295                 1300                 1305             


Ala Thr  Ile Lys Ser Leu Ala  Asp Cys Asn Phe Ser  Tyr Thr Ser 
    1310                 1315                 1320             


Ser Arg  Asp Ala Phe Gly Tyr  Ala Thr Leu Lys Arg  Leu Gln Gln 
    1325                 1330                 1335             


Gln Arg  Met His Pro Ser Leu  Ser His Ser Glu Ala  Leu Ala Ser 
    1340                 1345                 1350             


Pro Ala  Lys Asp Val Leu Phe  Thr Asp Thr Ile Thr  Met Lys Ala 
    1355                 1360                 1365             


Asn Ser  Phe Glu Ser Arg Leu  Thr Pro Ser Arg Ile  Asp Phe Lys 
    1370                 1375                 1380             


Lys Lys  His Val Gly Gly Ile  Arg Ser Leu Arg Pro  Thr Ile Thr 
    1385                 1390                 1395             


Asn Asn  Leu Phe Arg Phe Met  Lys Ala Leu Ser Tyr  Ala Ser Leu 
    1400                 1405                 1410             


Asp Lys  Glu Asp Leu Leu Ser  Pro Ile Asn Gln Asn  Thr Leu Gln 
    1415                 1420                 1425             


Arg Ser  Ser Ser Val Arg Ser  Met Val Ser Ser Ala  Thr Tyr Gly 
    1430                 1435                 1440             


Gly Ser  Asp Asp Tyr Ile Gly  Leu Ala Leu Pro Val  Asp Ile Asn 
    1445                 1450                 1455             


Asp Ile  Phe Gln Val Lys Asp  Ile Pro Tyr Phe Gln  Thr Lys Asn 
    1460                 1465                 1470             


Ile Pro  Pro His Asp Asp Arg  Gly Ala Arg Ala Phe  Ala His Asp 
    1475                 1480                 1485             


Ala Gly  Gly Leu Pro Ser Gly  Thr Gly Gly Leu Val  Lys Asn Ser 
    1490                 1495                 1500             


Phe His  Leu Leu Arg Gln Gln  Met Ser Leu Thr Glu  Ile Met Asn 
    1505                 1510                 1515             


Ser Ile  His Ser Asp Ala Ser  Leu Phe Leu Glu Ser  Thr Glu Asp 
    1520                 1525                 1530             


Thr Gly  Leu Gln Glu His Thr  Asp Asp Asn Cys Leu  Tyr Cys Val 
    1535                 1540                 1545             


Cys Ile  Glu Ile Leu Gly Phe  Gln Pro Ser Asn Gln  Leu Ser Ala 
    1550                 1555                 1560             


Ile Cys  Ser His Ser Asp Phe  Gln Asp Ile Pro Tyr  Ser Asp Trp 
    1565                 1570                 1575             


Cys Glu  Gln Thr Ile His Asn  Pro Leu Glu Val Val  Pro Ser Lys 
    1580                 1585                 1590             


Phe Ser  Gly Ile Ser Gly Cys  Ser Asp Gly Val Ser  Gln Glu Gly 
    1595                 1600                 1605             


Ser Ala  Ser Ser Thr Lys Ser  Thr Glu Leu Leu Leu  Gly Val Lys 
    1610                 1615                 1620             


Thr Ile  Pro Asp Asp Thr Pro  Met Cys Arg Ile Leu  Leu Arg Lys 
    1625                 1630                 1635             


Glu Val  Leu Arg Leu Val Ile  Asn Leu Ser Ser Ser  Val Ser Thr 
    1640                 1645                 1650             


Lys Cys  His Glu Thr Gly Leu  Leu Thr Ile Lys Glu  Lys Tyr Pro 
    1655                 1660                 1665             


Gln Thr  Phe Asp Asp Ile Cys  Leu Tyr Ser Glu Val  Ser His Leu 
    1670                 1675                 1680             


Leu Ser  His Cys Thr Phe Arg  Leu Pro Cys Arg Arg  Phe Ile Gln 
    1685                 1690                 1695             


Glu Leu  Phe Gln Asp Val Gln  Phe Leu Gln Met His  Glu Glu Ala 
    1700                 1705                 1710             


Glu Ala  Val Leu Ala Thr Pro  Pro Lys Gln Pro Ile  Val Asp Thr 
    1715                 1720                 1725             


Ser Ala  Glu Ser 
    1730         


<210> 5170
<211> 586
<212> PRT
<213> Homo sapiens

<400> 5170
Met Ser Ala Thr Val Val Asp Ala Val Asn Ala Ala Pro Leu Ser Gly 
1               5                   10                  15      


Ser Lys Glu Met Ser Leu Glu Glu Pro Lys Lys Met Thr Arg Glu Asp 
            20                  25                  30          


Trp Arg Lys Lys Lys Glu Leu Glu Glu Gln Arg Lys Leu Gly Asn Ala 
        35                  40                  45              


Pro Ala Glu Val Asp Glu Glu Gly Lys Asp Ile Asn Pro His Ile Pro 
    50                  55                  60                  


Gln Tyr Ile Ser Ser Val Pro Trp Tyr Ile Asp Pro Ser Lys Arg Pro 
65                  70                  75                  80  


Thr Leu Lys His Gln Arg Pro Gln Pro Glu Lys Gln Lys Gln Phe Ser 
                85                  90                  95      


Ser Ser Gly Glu Trp Tyr Lys Arg Gly Val Lys Glu Asn Ser Ile Ile 
            100                 105                 110         


Thr Lys Tyr Arg Lys Gly Ala Cys Glu Asn Cys Gly Ala Met Thr His 
        115                 120                 125             


Lys Lys Lys Asp Cys Phe Glu Arg Pro Arg Arg Val Gly Ala Lys Phe 
    130                 135                 140                 


Thr Gly Thr Asn Ile Ala Pro Asp Glu His Val Gln Pro Gln Leu Met 
145                 150                 155                 160 


Phe Asp Tyr Asp Gly Lys Arg Asp Arg Trp Asn Gly Tyr Asn Pro Glu 
                165                 170                 175     


Glu His Met Lys Ile Val Glu Glu Tyr Ala Lys Val Asp Leu Ala Lys 
            180                 185                 190         


Arg Thr Leu Lys Ala Gln Lys Leu Gln Glu Glu Leu Ala Ser Gly Lys 
        195                 200                 205             


Leu Val Glu Gln Ala Asn Ser Pro Lys His Gln Trp Gly Glu Glu Glu 
    210                 215                 220                 


Pro Asn Ser Gln Met Glu Lys Asp His Asn Ser Glu Asp Glu Asp Glu 
225                 230                 235                 240 


Asp Lys Tyr Ala Asp Asp Ile Asp Met Pro Gly Gln Asn Phe Asp Ser 
                245                 250                 255     


Lys Arg Arg Ile Thr Val Arg Asn Leu Arg Ile Arg Glu Asp Ile Ala 
            260                 265                 270         


Lys Tyr Leu Arg Asn Leu Asp Pro Asn Ser Ala Tyr Tyr Asp Pro Lys 
        275                 280                 285             


Thr Arg Ala Met Arg Glu Asn Pro Tyr Ala Asn Ala Gly Lys Asn Pro 
    290                 295                 300                 


Asp Glu Val Ser Tyr Ala Gly Asp Asn Phe Val Arg Tyr Thr Gly Asp 
305                 310                 315                 320 


Thr Ile Ser Met Ala Gln Thr Gln Leu Phe Ala Trp Glu Ala Tyr Asp 
                325                 330                 335     


Lys Gly Ser Glu Val His Leu Gln Ala Asp Pro Thr Lys Leu Glu Leu 
            340                 345                 350         


Leu Tyr Lys Ser Phe Lys Val Lys Lys Glu Asp Phe Lys Glu Gln Gln 
        355                 360                 365             


Lys Glu Ser Ile Leu Glu Lys Tyr Gly Gly Gln Glu His Leu Asp Ala 
    370                 375                 380                 


Pro Pro Ala Glu Leu Leu Leu Ala Gln Thr Glu Asp Tyr Val Glu Tyr 
385                 390                 395                 400 


Ser Arg His Gly Thr Val Ile Lys Gly Gln Glu Arg Ala Val Ala Cys 
                405                 410                 415     


Ser Lys Tyr Glu Glu Asp Val Lys Ile His Asn His Thr His Ile Trp 
            420                 425                 430         


Gly Ser Tyr Trp Lys Glu Gly Arg Trp Gly Tyr Lys Cys Cys His Ser 
        435                 440                 445             


Phe Phe Lys Tyr Ser Tyr Cys Thr Gly Glu Ala Gly Lys Glu Ile Val 
    450                 455                 460                 


Asn Ser Glu Glu Cys Ile Ile Asn Glu Ile Thr Gly Glu Glu Ser Val 
465                 470                 475                 480 


Lys Lys Pro Gln Thr Leu Met Glu Leu His Gln Glu Lys Leu Lys Glu 
                485                 490                 495     


Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys His Arg Lys Ser Ser 
            500                 505                 510         


Ser Asp Ser Asp Asp Glu Glu Lys Lys His Glu Lys Leu Lys Lys Ala 
        515                 520                 525             


Leu Asn Ala Glu Glu Ala Arg Leu Leu His Val Lys Glu Thr Met Gln 
    530                 535                 540                 


Ile Asp Glu Arg Lys Arg Pro Tyr Asn Ser Met Tyr Glu Thr Arg Glu 
545                 550                 555                 560 


Pro Thr Glu Glu Glu Met Glu Ala Tyr Arg Met Lys Arg Gln Arg Pro 
                565                 570                 575     


Asp Asp Pro Met Ala Ser Phe Leu Gly Gln 
            580                 585     


<210> 5171
<211> 394
<212> PRT
<213> Homo sapiens

<400> 5171
Met Ala Leu Glu Val Gly Asp Met Glu Asp Gly Gln Leu Ser Asp Ser 
1               5                   10                  15      


Asp Ser Asp Met Thr Val Ala Pro Ser Asp Arg Pro Leu Gln Leu Pro 
            20                  25                  30          


Lys Val Leu Gly Gly Asp Ser Ala Met Arg Ala Phe Gln Asn Thr Ala 
        35                  40                  45              


Thr Ala Cys Ala Pro Val Ser His Tyr Arg Ala Val Glu Ser Val Asp 
    50                  55                  60                  


Ser Ser Glu Glu Ser Phe Ser Asp Ser Asp Asp Asp Ser Cys Leu Trp 
65                  70                  75                  80  


Lys Arg Lys Arg Gln Lys Cys Phe Asn Pro Pro Pro Lys Pro Glu Pro 
                85                  90                  95      


Phe Gln Phe Gly Gln Ser Ser Gln Lys Pro Pro Val Ala Gly Gly Lys 
            100                 105                 110         


Lys Ile Asn Asn Ile Trp Gly Ala Val Leu Gln Glu Gln Asn Gln Asp 
        115                 120                 125             


Ala Val Ala Thr Glu Leu Gly Ile Leu Gly Met Glu Gly Thr Ile Asp 
    130                 135                 140                 


Arg Ser Arg Gln Ser Glu Thr Tyr Asn Tyr Leu Leu Ala Lys Lys Leu 
145                 150                 155                 160 


Arg Lys Glu Ser Gln Glu His Thr Lys Asp Leu Asp Lys Glu Leu Asp 
                165                 170                 175     


Glu Tyr Met His Gly Gly Lys Lys Met Gly Ser Lys Glu Glu Glu Asn 
            180                 185                 190         


Gly Gln Gly His Leu Lys Arg Lys Arg Pro Val Lys Asp Arg Leu Gly 
        195                 200                 205             


Asn Arg Pro Glu Met Asn Tyr Lys Gly Arg Tyr Glu Ile Thr Ala Glu 
    210                 215                 220                 


Asp Ser Gln Glu Lys Val Ala Asp Glu Ile Ser Phe Arg Leu Gln Glu 
225                 230                 235                 240 


Pro Lys Lys Asp Leu Ile Ala Arg Val Val Arg Ile Ile Gly Asn Lys 
                245                 250                 255     


Lys Ala Ile Glu Leu Leu Met Glu Thr Ala Glu Val Glu Gln Asn Gly 
            260                 265                 270         


Gly Leu Phe Ile Met Asn Gly Ser Arg Arg Arg Thr Pro Gly Gly Val 
        275                 280                 285             


Phe Leu Asn Leu Leu Lys Asn Thr Pro Ser Ile Ser Glu Glu Gln Ile 
    290                 295                 300                 


Lys Asp Ile Phe Tyr Ile Glu Asn Gln Lys Glu Tyr Glu Asn Lys Lys 
305                 310                 315                 320 


Ala Ala Arg Lys Arg Arg Thr Gln Val Leu Gly Lys Lys Met Lys Gln 
                325                 330                 335     


Ala Ile Lys Ser Leu Asn Phe Gln Glu Asp Asp Asp Thr Ser Arg Glu 
            340                 345                 350         


Thr Phe Ala Ser Asp Thr Asn Glu Ala Leu Ala Ser Leu Asp Glu Ser 
        355                 360                 365             


Gln Glu Gly His Ala Glu Ala Lys Leu Glu Ala Glu Glu Ala Ile Glu 
    370                 375                 380                 


Val Asp His Ser His Asp Leu Asp Ile Phe 
385                 390                 


<210> 5172
<211> 262
<212> PRT
<213> Homo sapiens

<400> 5172
Met Phe Leu Phe Ser Arg Lys Thr Arg Thr Pro Ile Ser Thr Tyr Ser 
1               5                   10                  15      


Asp Ser Tyr Arg Ala Pro Thr Ser Ile Lys Glu Val Tyr Lys Asp Pro 
            20                  25                  30          


Pro Leu Cys Ala Trp Glu Ala Asn Lys Phe Leu Thr Pro Gly Leu Thr 
        35                  40                  45              


His Thr Met Glu Arg His Val Asp Pro Glu Ala Leu Gln Lys Met Ala 
    50                  55                  60                  


Lys Cys Ala Val Gln Asp Tyr Thr Tyr Arg Gly Ser Ile Ser Gly His 
65                  70                  75                  80  


Pro Tyr Leu Pro Glu Lys Tyr Trp Leu Ser Gln Glu Glu Ala Asp Lys 
                85                  90                  95      


Cys Ser Pro Asn Tyr Leu Gly Ser Asp Trp Tyr Asn Thr Trp Arg Met 
            100                 105                 110         


Glu Pro Tyr Asn Ser Ser Cys Cys Asn Lys Tyr Thr Thr Tyr Leu Pro 
        115                 120                 125             


Arg Leu Pro Lys Glu Ala Arg Met Glu Thr Ala Val Arg Gly Met Pro 
    130                 135                 140                 


Leu Glu Cys Pro Pro Arg Pro Glu Arg Leu Asn Ala Tyr Glu Arg Glu 
145                 150                 155                 160 


Val Met Val Asn Met Leu Asn Ser Leu Ser Arg Asn Gln Gln Leu Pro 
                165                 170                 175     


Arg Ile Thr Pro Arg Cys Gly Cys Val Asp Pro Leu Pro Gly Arg Leu 
            180                 185                 190         


Pro Phe His Gly Tyr Glu Ser Ala Cys Ser Gly Arg His Tyr Cys Leu 
        195                 200                 205             


Arg Gly Met Asp Tyr Tyr Ala Ser Gly Ala Pro Cys Thr Asp Arg Arg 
    210                 215                 220                 


Leu Arg Pro Trp Cys Arg Glu Gln Pro Thr Met Cys Thr Ser Leu Arg 
225                 230                 235                 240 


Ala Pro Ala Arg Asn Ala Val Cys Cys Tyr Asn Ser Pro Ala Val Ile 
                245                 250                 255     


Leu Pro Ile Ser Glu Pro 
            260         


<210> 5173
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 5173
Met Glu Glu Ile Pro Val Lys Val Ala Val Arg Ile Arg Pro Leu Leu 
1               5                   10                  15      


Cys Lys Glu Ala Leu His Asn His Gln Val Cys Val Arg Val Ile Pro 
            20                  25                  30          


Asn Ser Gln Gln Val Ile Ile Gly Arg Asp Arg Val Phe Thr Phe Asp 
        35                  40                  45              


Phe Val Phe Gly Lys Asn Ser Thr Gln Asp Glu Val Tyr Asn Thr Cys 
    50                  55                  60                  


Ile Lys Pro Leu Val Leu Ser Leu Ile Glu Gly Tyr Asn Ala Thr Val 
65                  70                  75                  80  


Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr Tyr Thr Ile Gly Gly 
                85                  90                  95      


Gly His Ile Ala Ser Val Val Glu Gly Gln Lys Gly Ile Ile Pro Arg 
            100                 105                 110         


Ala Ile Gln Glu Ile Phe Gln Ser Ile Ser Glu His Pro Ser Ile Asp 
        115                 120                 125             


Phe Asn Val Lys Val Ser Tyr Ile Glu Val Tyr Lys Glu Asp Leu Arg 
    130                 135                 140                 


Asp Leu Leu Glu Leu Glu Thr Ser Met Lys Asp Leu His Ile Arg Glu 
145                 150                 155                 160 


Asp Glu Lys Gly Asn Thr Val Ile Val Gly Ala Lys Glu Cys His Val 
                165                 170                 175     


Glu Ser Ala Gly Glu Val Met Ser Leu Leu Glu Met Gly Asn Ala Ala 
            180                 185                 190         


Arg His Thr Gly Thr Thr Gln Met Asn Glu His Ser Ser Arg Ser His 
        195                 200                 205             


Ala Ile Phe Thr Ile Ser Ile Cys Gln Val His Lys Asn Met Glu Ala 
    210                 215                 220                 


Ala Glu Asp Gly Ser Trp Tyr Ser Pro Arg His Ile Val Ser Lys Phe 
225                 230                 235                 240 


His Phe Val Asp Leu Ala Gly Ser Glu Arg Val Thr Lys Thr Gly Asn 
                245                 250                 255     


Thr Gly Glu Arg Phe Lys Glu Ser Ile Gln Ile Asn Ser Gly Leu Leu 
            260                 265                 270         


Ala Leu Gly Asn Val Ile Ser Ala Leu Gly Asp Pro Arg Arg Lys Ser 
        275                 280                 285             


Ser His Ile Pro Tyr Arg Asp Ala Lys Ile Thr Arg Leu Leu Lys Asp 
    290                 295                 300                 


Ser Leu Gly Gly Ser Ala Lys Thr Val Met Ile Thr Cys Val Ser Pro 
305                 310                 315                 320 


Ser Ser Ser Asn Phe Asp Glu Ser Leu Asn Ser Leu Lys Tyr Ala Asn 
                325                 330                 335     


Arg Ala Arg Asn Ile Arg Asn Lys Pro Thr Val Asn Phe Ser Pro Glu 
            340                 345                 350         


Ser Asp Arg Ile Asp Glu Met Glu Phe Glu Ile Lys Leu Leu Arg Glu 
        355                 360                 365             


Ala Leu Gln Ser Gln Gln Ala Gly Val Ser Gln Thr Thr Gln Ile Asn 
    370                 375                 380                 


Arg Glu Gly Ser Pro Asp Thr Asn Arg Ile His Ser Leu Glu Glu Gln 
385                 390                 395                 400 


Val Ala Gln Leu Gln Gly Glu Cys Leu Gly Tyr Gln Cys Cys Val Glu 
                405                 410                 415     


Glu Ala Phe Thr Phe Leu Val Asp Leu Lys Asp Thr Val Arg Leu Asn 
            420                 425                 430         


Glu Lys Gln Gln His Lys Leu Gln Glu Trp Phe Asn Met Ile Gln Glu 
        435                 440                 445             


Val Arg Lys Ala Val Leu Thr Ser Phe Arg Gly Ile Gly Gly Thr Ala 
    450                 455                 460                 


Ser Leu Glu Glu Gly Pro Gln His Val Thr Val Leu Gln Leu Lys Arg 
465                 470                 475                 480 


Glu Leu Lys Lys Cys Gln Cys Val Leu Ala Ala Asp Glu Val Val Phe 
                485                 490                 495     


Asn Gln Lys Glu Leu Glu Val Lys Glu Leu Lys Asn Gln Val Gln Met 
            500                 505                 510         


Met Val Gln Glu Asn Lys Gly His Ala Val Ser Leu Lys Glu Ala Gln 
        515                 520                 525             


Lys Val Asn Arg Leu Gln Asn Glu Lys Ile Ile Glu Gln Gln Leu Leu 
    530                 535                 540                 


Val Asp Gln Leu Ser Glu Glu Leu Thr Lys Leu Asn Leu Ser Val Thr 
545                 550                 555                 560 


Ser Ser Ala Lys Glu Asn Cys Gly Asp Gly Pro Asp Ala Arg Ile Pro 
                565                 570                 575     


Glu Arg Arg Pro Tyr Thr Val Pro Phe Asp Thr His Leu Gly His Tyr 
            580                 585                 590         


Ile Tyr Ile Pro Ser Arg Gln Asp Ser Arg Lys Val His Thr Ser Pro 
        595                 600                 605             


Pro Met Tyr Ser Leu Asp Arg Ile Phe Ala Gly Phe Arg Thr Arg Ser 
    610                 615                 620                 


Gln Met Leu Leu Gly His Ile Glu Glu Gln Asp Lys Val Leu His Cys 
625                 630                 635                 640 


Gln Phe Ser Asp Asn Ser Asp Asp Glu Glu Ser Glu Gly Gln Glu Lys 
                645                 650                 655     


Ser Gly Thr Arg Cys Arg Ser Arg Ser Trp Ile Gln Lys Pro Asp Ser 
            660                 665                 670         


Val Cys Ser Leu Val Glu Leu Ser Asp Thr Gln Asp Glu Thr Gln Lys 
        675                 680                 685             


Ser Asp Leu Glu Asn Glu Asp Leu Lys Ile Asp Cys Leu Gln Glu Ser 
    690                 695                 700                 


Gln Glu Leu Asn Leu Gln Lys Leu Lys Asn Ser Glu Arg Ile Leu Thr 
705                 710                 715                 720 


Glu Ala Lys Gln Lys Met Arg Glu Leu Thr Ile Asn Ile Lys Met Lys 
                725                 730                 735     


Glu Asp Leu Ile Lys Glu Leu Ile Lys Thr Gly Asn Asp Ala Lys Ser 
            740                 745                 750         


Val Ser Lys Gln Tyr Ser Leu Lys Val Thr Lys Leu Glu His Asp Ala 
        755                 760                 765             


Glu Gln Ala Lys Val Glu Leu Ile Glu Thr Gln Lys Gln Leu Gln Glu 
    770                 775                 780                 


Leu Glu Asn Lys Asp Leu Ser Asp Val Ala Met Lys Val Lys Leu Gln 
785                 790                 795                 800 


Lys Glu Phe Arg Lys Lys Met Asp Ala Ala Lys Leu Arg Val Gln Val 
                805                 810                 815     


Leu Gln Lys Lys Gln Gln Asp Ser Lys Lys Leu Ala Ser Leu Ser Ile 
            820                 825                 830         


Gln Asn Glu Lys Arg Ala Asn Glu Leu Glu Gln Ser Val Asp His Met 
        835                 840                 845             


Lys Tyr Gln Lys Ile Gln Leu Gln Arg Lys Leu Arg Glu Glu Asn Glu 
    850                 855                 860                 


Lys Arg Lys Gln Leu Asp Ala Val Ile Lys Arg Asp Gln Gln Lys Ile 
865                 870                 875                 880 


Lys Glu Ile Gln Leu Lys Thr Gly Gln Glu Glu Gly Leu Lys Pro Lys 
                885                 890                 895     


Ala Glu Asp Leu Asp Ala Cys Asn Leu Lys Arg Arg Lys Gly Ser Phe 
            900                 905                 910         


Gly Ser Ile Asp His Leu Gln Lys Leu Asp Glu Gln Lys Lys Trp Leu 
        915                 920                 925             


Asp Glu Glu Val Glu Lys Val Leu Asn Gln Arg Gln Glu Leu Glu Glu 
    930                 935                 940                 


Leu Glu Ala Asp Leu Lys Lys Arg Glu Ala Ile Val Ser Lys Lys Glu 
945                 950                 955                 960 


Ala Leu Leu Gln Glu Lys Ser His Leu Glu Asn Lys Lys Leu Arg Ser 
                965                 970                 975     


Ser Gln Ala Leu Asn Thr Asp Ser Leu Lys Ile Ser Thr Arg Leu Asn 
            980                 985                 990         


Leu Leu Glu Gln Glu Leu Ser Glu  Lys Asn Val Gln Leu  Gln Thr Ser 
        995                 1000                 1005             


Thr Ala  Glu Glu Lys Thr Lys  Ile Ser Glu Gln Val  Glu Val Leu 
    1010                 1015                 1020             


Gln Lys  Glu Lys Asp Gln Leu  Gln Lys Arg Arg His  Asn Val Asp 
    1025                 1030                 1035             


Glu Lys  Leu Lys Asn Gly Arg  Val Leu Ser Pro Glu  Glu Glu His 
    1040                 1045                 1050             


Val Leu  Phe Gln Leu Glu Glu  Gly Ile Glu Ala Leu  Glu Ala Ala 
    1055                 1060                 1065             


Ile Glu  Tyr Arg Asn Glu Ser  Ile Gln Asn Arg Gln  Lys Ser Leu 
    1070                 1075                 1080             


Arg Ala  Ser Phe His Asn Leu  Ser Arg Gly Glu Ala  Asn Val Leu 
    1085                 1090                 1095             


Glu Lys  Leu Ala Cys Leu Ser  Pro Val Glu Ile Arg  Thr Ile Leu 
    1100                 1105                 1110             


Phe Arg  Tyr Phe Asn Lys Val  Val Asn Leu Arg Glu  Ala Glu Arg 
    1115                 1120                 1125             


Lys Gln  Gln Leu Tyr Asn Glu  Glu Met Lys Met Lys  Val Leu Glu 
    1130                 1135                 1140             


Arg Asp  Asn Met Val Arg Glu  Leu Glu Ser Ala Leu  Asp His Leu 
    1145                 1150                 1155             


Lys Leu  Gln Cys Asp Arg Arg  Leu Thr Leu Gln Gln  Lys Glu His 
    1160                 1165                 1170             


Glu Gln  Lys Met Gln Leu Leu  Leu His His Phe Lys  Glu Gln Asp 
    1175                 1180                 1185             


Gly Glu  Gly Ile Met Glu Thr  Phe Lys Thr Tyr Glu  Asp Lys Ile 
    1190                 1195                 1200             


Gln Gln  Leu Glu Lys Asp Leu  Tyr Phe Tyr Lys Lys  Thr Ser Arg 
    1205                 1210                 1215             


Asp His  Lys Lys Lys Leu Lys  Glu Leu Val Gly Glu  Ala Ile Arg 
    1220                 1225                 1230             


Arg Gln  Leu Ala Pro Ser Glu  Tyr Gln Glu Ala Gly  Asp Gly Val 
    1235                 1240                 1245             


Leu Lys  Pro Glu Gly Gly Gly  Met Leu Ser Glu Glu  Leu Lys Trp 
    1250                 1255                 1260             


Ala Ser  Arg Pro Glu Ser Met  Lys Leu Ser Gly Arg  Glu Arg Glu 
    1265                 1270                 1275             


Met Asp  Ser Ser Ala Ser Ser  Leu Arg Thr Gln Pro  Asn Pro Gln 
    1280                 1285                 1290             


Lys Leu  Trp Glu Asp Ile Pro  Glu Leu Pro Pro Ile  His Ser Ser 
    1295                 1300                 1305             


Leu Ala  Pro Pro Ser Gly His  Met Leu Gly Asn Glu  Asn Lys Thr 
    1310                 1315                 1320             


Glu Thr  Asp Asp Asn Gln Phe  Thr Lys Ser His Ser  Arg Leu Ser 
    1325                 1330                 1335             


Ser Gln  Ile Gln Val Val Gly  Asn Val Gly Arg Leu  His Gly Val 
    1340                 1345                 1350             


Thr Pro  Val Lys Leu Cys Arg  Lys Glu Leu Arg Gln  Ile Ser Ala 
    1355                 1360                 1365             


Leu Glu  Leu Ser Leu Arg Arg  Ser Ser Leu Gly Val  Gly Ile Gly 
    1370                 1375                 1380             


Ser Met  Ala Ala Asp Ser Ile  Glu Val Ser Arg Lys  Pro Arg Asp 
    1385                 1390                 1395             


Leu Lys  Thr 
    1400     


<210> 5174
<211> 255
<212> PRT
<213> Homo sapiens

<400> 5174
Met Val Lys Gly Glu Lys Gly Pro Lys Gly Lys Lys Ile Thr Leu Lys 
1               5                   10                  15      


Val Ala Arg Asn Cys Ile Lys Ile Thr Phe Asp Gly Lys Lys Arg Leu 
            20                  25                  30          


Asp Leu Ser Lys Met Gly Ile Thr Thr Phe Pro Lys Cys Ile Leu Arg 
        35                  40                  45              


Leu Ser Asp Met Asp Glu Leu Asp Leu Ser Arg Asn Leu Ile Arg Lys 
    50                  55                  60                  


Ile Pro Asp Ser Ile Ser Lys Phe Gln Asn Leu Arg Trp Leu Asp Leu 
65                  70                  75                  80  


His Ser Asn Tyr Ile Asp Lys Leu Pro Glu Ser Ile Gly Gln Met Thr 
                85                  90                  95      


Ser Leu Leu Tyr Leu Asn Val Ser Asn Asn Arg Leu Thr Ser Asn Gly 
            100                 105                 110         


Leu Pro Val Glu Leu Lys Gln Leu Lys Asn Ile Arg Ala Val Asn Leu 
        115                 120                 125             


Gly Leu Asn His Leu Asp Ser Val Pro Thr Thr Leu Gly Ala Leu Lys 
    130                 135                 140                 


Glu Leu His Glu Val Gly Leu His Asp Asn Leu Leu Asn Asn Ile Pro 
145                 150                 155                 160 


Val Ser Ile Ser Lys Leu Pro Lys Leu Lys Lys Leu Asn Ile Lys Arg 
                165                 170                 175     


Asn Pro Phe Pro Lys Pro Gly Glu Ser Glu Ile Phe Ile Asp Ser Ile 
            180                 185                 190         


Arg Arg Leu Glu Asn Leu Tyr Val Val Glu Glu Lys Asp Leu Cys Ala 
        195                 200                 205             


Ala Cys Leu Arg Lys Cys Gln Asn Ala Arg Asp Asn Leu Asn Arg Ile 
    210                 215                 220                 


Lys Asn Met Ala Thr Thr Thr Pro Arg Lys Thr Ile Phe Pro Asn Leu 
225                 230                 235                 240 


Ile Ser Pro Asn Ser Met Ala Lys Asp Ser Trp Glu Asp Trp Arg 
                245                 250                 255 


<210> 5175
<211> 214
<212> PRT
<213> Homo sapiens

<400> 5175
Met Gly Arg Arg Pro Ala Arg Cys Tyr Arg Tyr Cys Lys Asn Lys Pro 
1               5                   10                  15      


Tyr Pro Lys Ser Arg Phe Cys Arg Gly Val Pro Asp Ala Lys Ile Arg 
            20                  25                  30          


Ile Phe Asp Leu Gly Arg Lys Lys Ala Lys Val Asp Glu Phe Pro Leu 
        35                  40                  45              


Gly Gly His Met Val Ser Asp Glu Tyr Glu Gln Leu Ser Ser Glu Ala 
    50                  55                  60                  


Leu Glu Ala Ala Arg Ile Cys Ala Asn Lys Tyr Met Val Lys Ser Cys 
65                  70                  75                  80  


Gly Arg Asp Gly Phe His Met Arg Val Arg Leu His Pro Phe His Val 
                85                  90                  95      


Ile Arg Ile Asn Lys Met Leu Ser Cys Ala Gly Ala Asp Arg Leu Gln 
            100                 105                 110         


Thr Gly Met Arg Gly Ala Phe Gly Lys Pro Gln Gly Thr Val Ala Arg 
        115                 120                 125             


Val His Ile Gly Gln Val Ile Met Ser Ile Arg Thr Lys Leu Gln Asn 
    130                 135                 140                 


Glu Glu His Val Ile Glu Ala Leu Arg Arg Ala Lys Phe Lys Phe Pro 
145                 150                 155                 160 


Gly Arg Gln Lys Ile His Ile Ser Lys Lys Trp Gly Phe Thr Lys Phe 
                165                 170                 175     


Asn Ala Asp Glu Phe Glu Asp Met Val Ala Lys Lys Cys Leu Ile Pro 
            180                 185                 190         


Asp Gly Cys Gly Val Lys Tyr Val Pro Ser His Gly Pro Leu Asp Lys 
        195                 200                 205             


Trp Arg Val Leu His Ser 
    210                 


<210> 5176
<211> 1076
<212> PRT
<213> Homo sapiens

<400> 5176
Met Lys Ser Arg Phe Ser Thr Ile Asp Leu Arg Ala Val Leu Ala Glu 
1               5                   10                  15      


Leu Asn Ala Ser Leu Leu Gly Met Arg Val Asn Asn Val Tyr Asp Val 
            20                  25                  30          


Asp Asn Lys Thr Tyr Leu Ile Arg Leu Gln Lys Pro Asp Phe Lys Ala 
        35                  40                  45              


Thr Leu Leu Leu Glu Ser Gly Ile Arg Ile His Thr Thr Glu Phe Glu 
    50                  55                  60                  


Trp Pro Lys Asn Met Met Pro Ser Ser Phe Ala Met Lys Cys Arg Lys 
65                  70                  75                  80  


His Leu Lys Ser Arg Arg Leu Val Ser Ala Lys Gln Leu Gly Val Asp 
                85                  90                  95      


Arg Ile Val Asp Phe Gln Phe Gly Ser Asp Glu Ala Ala Tyr His Leu 
            100                 105                 110         


Ile Ile Glu Leu Tyr Asp Arg Gly Asn Ile Val Leu Thr Asp Tyr Glu 
        115                 120                 125             


Tyr Val Ile Leu Asn Ile Leu Arg Phe Arg Thr Asp Glu Ala Asp Asp 
    130                 135                 140                 


Val Lys Phe Ala Val Arg Glu Arg Tyr Pro Leu Asp His Ala Arg Ala 
145                 150                 155                 160 


Ala Glu Pro Leu Leu Thr Leu Glu Arg Leu Thr Glu Ile Val Ala Ser 
                165                 170                 175     


Ala Pro Lys Gly Glu Leu Leu Lys Arg Val Leu Asn Pro Leu Leu Pro 
            180                 185                 190         


Tyr Gly Pro Ala Leu Ile Glu His Cys Leu Leu Glu Asn Gly Phe Ser 
        195                 200                 205             


Gly Asn Val Lys Val Asp Glu Lys Leu Glu Thr Lys Asp Ile Glu Lys 
    210                 215                 220                 


Val Leu Val Ser Leu Gln Lys Ala Glu Asp Tyr Met Lys Thr Thr Ser 
225                 230                 235                 240 


Asn Phe Ser Gly Lys Gly Tyr Ile Ile Gln Lys Arg Glu Ile Lys Pro 
                245                 250                 255     


Ser Leu Glu Ala Asp Lys Pro Val Glu Asp Ile Leu Thr Tyr Glu Glu 
            260                 265                 270         


Phe His Pro Phe Leu Phe Ser Gln His Ser Gln Cys Pro Tyr Ile Glu 
        275                 280                 285             


Phe Glu Ser Phe Asp Lys Ala Val Asp Glu Phe Tyr Ser Lys Ile Glu 
    290                 295                 300                 


Gly Gln Lys Ile Asp Leu Lys Ala Leu Gln Gln Glu Lys Gln Ala Leu 
305                 310                 315                 320 


Lys Lys Leu Asp Asn Val Arg Lys Asp His Glu Asn Arg Leu Glu Ala 
                325                 330                 335     


Leu Gln Gln Ala Gln Glu Ile Asp Lys Leu Lys Gly Glu Leu Ile Glu 
            340                 345                 350         


Met Asn Leu Gln Ile Val Asp Arg Ala Ile Gln Val Val Arg Ser Ala 
        355                 360                 365             


Leu Ala Asn Gln Ile Asp Trp Thr Glu Ile Gly Leu Ile Val Lys Glu 
    370                 375                 380                 


Ala Gln Ala Gln Gly Asp Pro Val Ala Ser Ala Ile Lys Glu Leu Lys 
385                 390                 395                 400 


Leu Gln Thr Asn His Val Thr Met Leu Leu Arg Asn Pro Tyr Leu Leu 
                405                 410                 415     


Ser Glu Glu Glu Asp Asp Asp Val Asp Gly Asp Val Asn Val Glu Lys 
            420                 425                 430         


Asn Glu Thr Glu Pro Pro Lys Gly Lys Lys Lys Lys Gln Lys Asn Lys 
        435                 440                 445             


Gln Leu Gln Lys Pro Gln Lys Asn Lys Pro Leu Leu Val Asp Val Asp 
    450                 455                 460                 


Leu Ser Leu Ser Ala Tyr Ala Asn Ala Lys Lys Tyr Tyr Asp His Lys 
465                 470                 475                 480 


Arg Tyr Ala Ala Lys Lys Thr Gln Lys Thr Val Glu Ala Ala Glu Lys 
                485                 490                 495     


Ala Phe Lys Ser Ala Glu Lys Lys Thr Lys Gln Thr Leu Lys Glu Val 
            500                 505                 510         


Gln Thr Val Thr Ser Ile Gln Lys Ala Arg Lys Val Tyr Trp Phe Glu 
        515                 520                 525             


Lys Phe Leu Trp Phe Ile Ser Ser Glu Asn Tyr Leu Ile Ile Gly Gly 
    530                 535                 540                 


Arg Asp Gln Gln Gln Asn Glu Ile Ile Val Lys Arg Tyr Leu Thr Pro 
545                 550                 555                 560 


Gly Asp Ile Tyr Val His Ala Asp Leu His Gly Ala Thr Ser Cys Val 
                565                 570                 575     


Ile Lys Asn Pro Thr Gly Glu Pro Ile Pro Pro Arg Thr Leu Thr Glu 
            580                 585                 590         


Ala Gly Thr Met Ala Leu Cys Tyr Ser Ala Ala Trp Asp Ala Arg Val 
        595                 600                 605             


Ile Thr Ser Ala Trp Trp Val Tyr His His Gln Val Ser Lys Thr Ala 
    610                 615                 620                 


Pro Thr Gly Glu Tyr Leu Thr Thr Gly Ser Phe Met Ile Arg Gly Lys 
625                 630                 635                 640 


Lys Asn Phe Leu Pro Pro Ser Tyr Leu Met Met Gly Phe Ser Phe Leu 
                645                 650                 655     


Phe Lys Val Asp Glu Ser Cys Val Trp Arg His Gln Gly Glu Arg Lys 
            660                 665                 670         


Val Arg Val Gln Asp Glu Asp Met Glu Thr Leu Ala Ser Cys Thr Ser 
        675                 680                 685             


Glu Leu Ile Ser Glu Glu Met Glu Gln Leu Asp Gly Gly Asp Thr Ser 
    690                 695                 700                 


Ser Asp Glu Asp Lys Glu Glu His Glu Thr Pro Val Glu Val Glu Leu 
705                 710                 715                 720 


Met Thr Gln Val Asp Gln Glu Asp Ile Thr Leu Gln Ser Gly Arg Asp 
                725                 730                 735     


Glu Leu Asn Glu Glu Leu Ile Gln Glu Glu Ser Ser Glu Asp Glu Gly 
            740                 745                 750         


Glu Tyr Glu Glu Val Arg Lys Asp Gln Asp Ser Val Gly Glu Met Lys 
        755                 760                 765             


Asp Glu Gly Glu Glu Thr Leu Asn Tyr Pro Asp Thr Thr Ile Asp Leu 
    770                 775                 780                 


Ser His Leu Gln Pro Gln Arg Ser Ile Gln Lys Leu Ala Ser Lys Glu 
785                 790                 795                 800 


Glu Ser Ser Asn Ser Ser Asp Ser Lys Ser Gln Ser Arg Arg His Leu 
                805                 810                 815     


Ser Ala Lys Glu Arg Arg Glu Met Lys Lys Lys Lys Leu Pro Ser Asp 
            820                 825                 830         


Ser Gly Asp Leu Glu Ala Leu Glu Gly Lys Asp Lys Glu Lys Glu Ser 
        835                 840                 845             


Thr Val His Ile Glu Thr His Gln Asn Thr Ser Lys Asn Val Ala Ala 
    850                 855                 860                 


Val Gln Pro Met Lys Arg Gly Gln Lys Ser Lys Met Lys Lys Met Lys 
865                 870                 875                 880 


Glu Lys Tyr Lys Asp Gln Asp Glu Glu Asp Arg Glu Leu Ile Met Lys 
                885                 890                 895     


Leu Leu Gly Ser Ala Gly Ser Asn Lys Glu Glu Lys Gly Lys Lys Gly 
            900                 905                 910         


Lys Lys Gly Lys Thr Lys Asp Glu Pro Val Lys Lys Gln Pro Gln Lys 
        915                 920                 925             


Pro Arg Gly Gly Gln Arg Val Ser Asp Asn Ile Lys Lys Glu Thr Pro 
    930                 935                 940                 


Phe Leu Glu Val Ile Thr His Glu Leu Gln Asp Phe Ala Val Asp Asp 
945                 950                 955                 960 


Pro His Asp Asp Lys Glu Glu Gln Asp Leu Asp Gln Gln Gly Asn Glu 
                965                 970                 975     


Glu Asn Leu Phe Asp Ser Leu Thr Gly Gln Pro His Pro Glu Asp Val 
            980                 985                 990         


Leu Leu Phe Ala Ile Pro Ile Cys  Ala Pro Tyr Thr Thr  Met Thr Asn 
        995                 1000                 1005             


Tyr Lys  Tyr Lys Val Lys Leu  Thr Pro Gly Val Gln  Lys Lys Gly 
    1010                 1015                 1020             


Lys Ala  Ala Lys Thr Ala Leu  Asn Ser Phe Met His  Ser Lys Glu 
    1025                 1030                 1035             


Ala Thr  Ala Arg Glu Lys Asp  Leu Phe Arg Ser Val  Lys Asp Thr 
    1040                 1045                 1050             


Asp Leu  Ser Arg Asn Ile Pro  Gly Lys Val Lys Val  Ser Ala Pro 
    1055                 1060                 1065             


Asn Leu  Leu Asn Val Lys Arg  Lys 
    1070                 1075     


<210> 5177
<211> 320
<212> PRT
<213> Homo sapiens

<400> 5177
Met Gly Asp Ile Pro Ala Val Gly Leu Ser Ser Trp Lys Ala Ser Pro 
1               5                   10                  15      


Gly Lys Val Thr Glu Ala Val Lys Glu Ala Ile Asp Ala Gly Tyr Arg 
            20                  25                  30          


His Phe Asp Cys Ala Tyr Phe Tyr His Asn Glu Arg Glu Val Gly Ala 
        35                  40                  45              


Gly Ile Arg Cys Lys Ile Lys Glu Gly Ala Val Arg Arg Glu Asp Leu 
    50                  55                  60                  


Phe Ile Ala Thr Lys Leu Trp Cys Thr Cys His Lys Lys Ser Leu Val 
65                  70                  75                  80  


Glu Thr Ala Cys Arg Lys Ser Leu Lys Ala Leu Lys Leu Asn Tyr Leu 
                85                  90                  95      


Asp Leu Tyr Leu Ile His Trp Pro Met Gly Phe Lys Pro Pro His Pro 
            100                 105                 110         


Glu Trp Ile Met Ser Cys Ser Glu Leu Ser Phe Cys Leu Ser His Pro 
        115                 120                 125             


Arg Val Gln Asp Leu Pro Leu Asp Glu Ser Asn Met Val Ile Pro Ser 
    130                 135                 140                 


Asp Thr Asp Phe Leu Asp Thr Trp Glu Ala Met Glu Asp Leu Val Ile 
145                 150                 155                 160 


Thr Gly Leu Val Lys Asn Ile Gly Val Ser Asn Phe Asn His Glu Gln 
                165                 170                 175     


Leu Glu Arg Leu Leu Asn Lys Pro Gly Leu Arg Phe Lys Pro Leu Thr 
            180                 185                 190         


Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln Lys Asn Leu Ile Ser 
        195                 200                 205             


Phe Cys Gln Ser Arg Asp Val Ser Val Thr Ala Tyr Arg Pro Leu Gly 
    210                 215                 220                 


Gly Ser Cys Glu Gly Val Asp Leu Ile Asp Asn Pro Val Ile Lys Arg 
225                 230                 235                 240 


Ile Ala Lys Glu His Gly Lys Ser Pro Ala Gln Ile Leu Ile Arg Phe 
                245                 250                 255     


Gln Ile Gln Arg Asn Val Ile Val Ile Pro Gly Ser Ile Thr Pro Ser 
            260                 265                 270         


His Ile Lys Glu Asn Ile Gln Val Phe Asp Phe Glu Leu Thr Gln His 
        275                 280                 285             


Asp Met Asp Asn Ile Leu Ser Leu Asn Arg Asn Leu Arg Leu Ala Met 
    290                 295                 300                 


Phe Pro Ile Thr Lys Asn His Lys Asp Tyr Pro Phe His Ile Glu Tyr 
305                 310                 315                 320 


<210> 5178
<211> 412
<212> PRT
<213> Homo sapiens

<400> 5178
Met Ser Gly Tyr Gln Arg Arg Pro Gly Ala Thr Pro Leu Ser Arg Ala 
1               5                   10                  15      


Arg Ser Leu Ala Ile Pro Asp Ala Pro Ala Phe Tyr Glu Arg Arg Ser 
            20                  25                  30          


Cys Leu Pro Gln Leu Asn Cys Glu Arg Pro His Gly Arg Asp Leu Asp 
        35                  40                  45              


Ser Pro Phe Phe Gly Ile Arg Pro Ala Phe Met Cys Tyr Val Pro Ser 
    50                  55                  60                  


Pro Val Leu Ala Ser Val Gly Asp Thr Asp Asp Arg Phe Glu Asp Leu 
65                  70                  75                  80  


Glu Glu Ala Asn Pro Phe Ser Phe Arg Glu Phe Leu Lys Thr Lys Asn 
                85                  90                  95      


Leu Gly Leu Ser Lys Glu Asp Pro Ala Ser Arg Ile Tyr Ala Lys Glu 
            100                 105                 110         


Ala Ser Arg His Ser Leu Gly Leu Asp His Asn Ser Pro Pro Ser Gln 
        115                 120                 125             


Thr Gly Gly Tyr Gly Leu Glu Tyr Gln Gln Pro Phe Phe Glu Asp Pro 
    130                 135                 140                 


Thr Gly Ala Gly Asp Leu Leu Asp Glu Glu Glu Asp Glu Asp Thr Gly 
145                 150                 155                 160 


Trp Ser Gly Ala Tyr Leu Pro Ser Ala Ile Glu Gln Thr His Pro Glu 
                165                 170                 175     


Arg Val Pro Ala Gly Thr Ser Pro Cys Ser Thr Tyr Leu Ser Phe Phe 
            180                 185                 190         


Ser Thr Pro Ser Glu Leu Ala Gly Pro Glu Ser Leu Pro Ser Trp Ala 
        195                 200                 205             


Leu Ser Asp Thr Asp Ser Arg Val Ser Pro Ala Ser Pro Ala Gly Ser 
    210                 215                 220                 


Pro Ser Ala Asp Phe Ala Val His Gly Glu Ser Leu Gly Asp Arg His 
225                 230                 235                 240 


Leu Arg Thr Leu Gln Ile Ser Tyr Asp Ala Leu Lys Asp Glu Asn Ser 
                245                 250                 255     


Lys Leu Arg Arg Lys Leu Asn Glu Val Gln Ser Phe Ser Glu Ala Gln 
            260                 265                 270         


Thr Glu Met Val Arg Thr Leu Glu Arg Lys Leu Glu Ala Lys Met Ile 
        275                 280                 285             


Lys Glu Glu Ser Asp Tyr His Asp Leu Glu Ser Val Val Gln Gln Val 
    290                 295                 300                 


Glu Gln Asn Leu Glu Leu Met Thr Lys Arg Ala Val Lys Ala Glu Asn 
305                 310                 315                 320 


His Val Val Lys Leu Lys Gln Glu Ile Ser Leu Leu Gln Ala Gln Val 
                325                 330                 335     


Ser Asn Phe Gln Arg Glu Asn Glu Ala Leu Arg Cys Gly Gln Gly Ala 
            340                 345                 350         


Ser Leu Thr Val Val Lys Gln Asn Ala Asp Val Ala Leu Gln Asn Leu 
        355                 360                 365             


Arg Val Val Met Asn Ser Ala Gln Ala Ser Ile Lys Gln Leu Val Ser 
    370                 375                 380                 


Gly Ala Glu Thr Leu Asn Leu Val Ala Glu Ile Leu Lys Ser Ile Asp 
385                 390                 395                 400 


Arg Ile Ser Glu Val Lys Asp Glu Glu Glu Asp Ser 
                405                 410         


<210> 5179
<211> 479
<212> PRT
<213> Homo sapiens

<400> 5179
Met Asp Ala Thr Ile Ala Pro His Arg Ile Pro Pro Glu Met Pro Gln 
1               5                   10                  15      


Tyr Gly Glu Glu Asn His Ile Phe Glu Leu Met Gln Asn Met Leu Glu 
            20                  25                  30          


Gln Leu Leu Ile His Gln Pro Glu Asp Pro Ile Pro Phe Met Ile Gln 
        35                  40                  45              


His Leu His Arg Asp Asn Asp Asn Val Pro Arg Ile Val Ile Leu Gly 
    50                  55                  60                  


Pro Pro Ala Ser Gly Lys Thr Thr Ile Ala Met Trp Leu Cys Lys His 
65                  70                  75                  80  


Leu Asn Ser Ser Leu Leu Thr Leu Glu Asn Leu Ile Leu Asn Glu Phe 
                85                  90                  95      


Ser Tyr Thr Ala Thr Glu Ala Arg Arg Leu Tyr Leu Gln Arg Lys Thr 
            100                 105                 110         


Val Pro Ser Ala Leu Leu Val Gln Leu Ile Gln Glu Arg Leu Ala Glu 
        115                 120                 125             


Glu Asp Cys Ile Lys Gln Gly Trp Ile Leu Asp Gly Ile Pro Glu Thr 
    130                 135                 140                 


Arg Glu Gln Ala Leu Arg Ile Gln Thr Leu Gly Ile Thr Pro Arg His 
145                 150                 155                 160 


Val Ile Val Leu Ser Ala Pro Asp Thr Val Leu Ile Glu Arg Asn Leu 
                165                 170                 175     


Gly Lys Arg Ile Asp Pro Gln Thr Gly Glu Ile Tyr His Thr Thr Phe 
            180                 185                 190         


Asp Trp Pro Pro Glu Ser Glu Ile Gln Asn Arg Leu Met Val Pro Glu 
        195                 200                 205             


Asp Ile Ser Glu Leu Glu Thr Ala Gln Lys Leu Leu Glu Tyr His Arg 
    210                 215                 220                 


Asn Ile Val Arg Val Ile Pro Ser Tyr Pro Lys Ile Leu Lys Val Ile 
225                 230                 235                 240 


Ser Ala Asp Gln Pro Cys Val Asp Val Phe Tyr Gln Ala Leu Thr Tyr 
                245                 250                 255     


Val Gln Ser Asn His Arg Thr Asn Ala Pro Phe Thr Pro Arg Val Leu 
            260                 265                 270         


Leu Leu Gly Pro Val Gly Ser Gly Lys Ser Leu Gln Ala Ala Leu Leu 
        275                 280                 285             


Ala Gln Lys Tyr Arg Leu Val Asn Val Cys Cys Gly Gln Leu Leu Lys 
    290                 295                 300                 


Glu Ala Val Ala Asp Arg Thr Thr Phe Gly Glu Leu Ile Gln Pro Phe 
305                 310                 315                 320 


Phe Glu Lys Glu Met Ala Val Pro Asp Ser Leu Leu Met Lys Val Leu 
                325                 330                 335     


Ser Gln Arg Leu Asp Gln Gln Asp Cys Ile Gln Lys Gly Trp Val Leu 
            340                 345                 350         


His Gly Val Pro Arg Asp Leu Asp Gln Ala His Leu Leu Asn Arg Leu 
        355                 360                 365             


Gly Tyr Asn Pro Asn Arg Val Phe Phe Leu Asn Val Pro Phe Asp Ser 
    370                 375                 380                 


Ile Met Glu Arg Leu Thr Leu Arg Arg Ile Asp Pro Val Thr Gly Glu 
385                 390                 395                 400 


Arg Tyr His Leu Met Tyr Lys Pro Pro Pro Thr Met Glu Ile Gln Ala 
                405                 410                 415     


Arg Leu Leu Gln Asn Pro Lys Asp Ala Glu Glu Gln Val Lys Leu Lys 
            420                 425                 430         


Met Asp Leu Phe Tyr Arg Asn Ser Ala Asp Leu Glu Gln Leu Tyr Gly 
        435                 440                 445             


Ser Ala Ile Thr Leu Asn Gly Asp Gln Asp Pro Tyr Thr Val Phe Glu 
    450                 455                 460                 


Tyr Ile Glu Ser Gly Ile Ile Asn Pro Leu Pro Lys Lys Ile Pro 
465                 470                 475                 


<210> 5180
<211> 143
<212> PRT
<213> Homo sapiens

<400> 5180
Met Ala His Glu Met Ile Gly Thr Gln Ile Val Thr Glu Arg Leu Val 
1               5                   10                  15      


Ala Leu Leu Glu Ser Gly Thr Glu Lys Val Leu Leu Ile Asp Ser Arg 
            20                  25                  30          


Pro Phe Val Glu Tyr Asn Thr Ser His Ile Leu Glu Ala Ile Asn Ile 
        35                  40                  45              


Asn Cys Ser Lys Leu Met Lys Arg Arg Leu Gln Gln Asp Lys Val Leu 
    50                  55                  60                  


Ile Thr Glu Leu Ile Gln His Ser Ala Lys His Lys Val Asp Ile Asp 
65                  70                  75                  80  


Cys Ser Gln Lys Val Val Val Tyr Asp Gln Ser Ser Gln Asp Val Ala 
                85                  90                  95      


Ser Leu Ser Ser Asp Cys Phe Leu Thr Val Leu Leu Gly Lys Leu Glu 
            100                 105                 110         


Lys Ser Phe Asn Ser Val His Leu Leu Ala Gly Ala Asp Ala Ala Glu 
        115                 120                 125             


Trp Asp Trp Leu Cys Val Lys Cys Gln Gln Tyr Leu Ser Lys Ala 
    130                 135                 140             


<210> 5181
<211> 396
<212> PRT
<213> Homo sapiens

<400> 5181
Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg 
1               5                   10                  15      


Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala 
            20                  25                  30          


Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu 
        35                  40                  45              


Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro 
    50                  55                  60                  


Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln 
65                  70                  75                  80  


Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu 
                85                  90                  95      


Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu 
            100                 105                 110         


Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His 
        115                 120                 125             


Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His 
    130                 135                 140                 


Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly 
                165                 170                 175     


Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro 
            180                 185                 190         


Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp 
        195                 200                 205             


Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala 
    210                 215                 220                 


Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile 
225                 230                 235                 240 


Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu 
                245                 250                 255     


Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly 
            260                 265                 270         


Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu 
        275                 280                 285             


Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile 
    290                 295                 300                 


Gln Ser Phe Thr Leu Leu Pro Thr Leu Glu Tyr Ser Gly Thr Val Ser 
305                 310                 315                 320 


Ala His Cys Asn Leu Arg Leu Pro Gly Ser Ser Asn Ser Arg Ala Ser 
                325                 330                 335     


Ala Ser His Val Ala Gly Ile Lys Cys Ala Arg His His Thr Arg Leu 
            340                 345                 350         


Ile Phe Phe Cys Ile Leu Val Glu Thr Glu Phe His His Val Ala Lys 
        355                 360                 365             


Ala Gly Leu Glu Leu Leu Ser Ser Gly Asn Pro Pro Ile Ser Asp Phe 
    370                 375                 380                 


Gln Ser Ala Arg Ile Thr Gly Val Ser His His Ala 
385                 390                 395     


<210> 5182
<211> 1471
<212> PRT
<213> Homo sapiens

<400> 5182
Met Glu Pro Glu Pro Val Glu Asp Cys Val Gln Ser Thr Leu Ala Ala 
1               5                   10                  15      


Leu Tyr Pro Pro Phe Glu Ala Thr Ala Pro Thr Leu Leu Gly Gln Val 
            20                  25                  30          


Phe Gln Val Val Glu Arg Thr Tyr Arg Glu Asp Ala Leu Arg Tyr Thr 
        35                  40                  45              


Leu Asp Phe Leu Val Pro Ala Lys His Leu Leu Ala Lys Val Gln Gln 
    50                  55                  60                  


Glu Ala Cys Ala Gln Tyr Ser Gly Phe Leu Phe Phe His Glu Gly Trp 
65                  70                  75                  80  


Pro Leu Cys Leu His Glu Gln Val Val Val Gln Leu Ala Ala Leu Pro 
                85                  90                  95      


Trp Gln Leu Leu Arg Pro Gly Asp Phe Tyr Leu Gln Val Val Pro Ser 
            100                 105                 110         


Ala Ala Gln Ala Pro Arg Leu Ala Leu Lys Cys Leu Ala Pro Gly Gly 
        115                 120                 125             


Gly Arg Val Gln Glu Val Pro Val Pro Asn Glu Ala Cys Ala Tyr Leu 
    130                 135                 140                 


Phe Thr Pro Glu Trp Leu Gln Gly Ile Asn Lys Asp Arg Pro Thr Gly 
145                 150                 155                 160 


Arg Leu Ser Thr Cys Leu Leu Ser Ala Pro Ser Gly Ile Gln Arg Leu 
                165                 170                 175     


Pro Trp Ala Glu Leu Ile Cys Pro Arg Phe Val His Lys Glu Gly Leu 
            180                 185                 190         


Met Val Gly His Gln Pro Ser Thr Leu Pro Pro Glu Leu Pro Ser Gly 
        195                 200                 205             


Pro Pro Gly Leu Pro Ser Pro Pro Leu Pro Glu Glu Ala Leu Gly Thr 
    210                 215                 220                 


Arg Ser Pro Gly Asp Gly His Asn Ala Pro Val Glu Gly Pro Glu Gly 
225                 230                 235                 240 


Glu Tyr Val Glu Leu Leu Glu Val Thr Leu Pro Val Arg Gly Ser Pro 
                245                 250                 255     


Thr Asp Ala Glu Gly Ser Pro Gly Leu Ser Arg Val Arg Thr Val Pro 
            260                 265                 270         


Thr Arg Lys Gly Ala Gly Gly Lys Gly Arg His Arg Arg His Arg Ala 
        275                 280                 285             


Trp Met His Gln Lys Gly Leu Gly Pro Arg Gly Gln Asp Gly Ala Arg 
    290                 295                 300                 


Pro Pro Gly Glu Gly Ser Ser Thr Gly Ala Ser Pro Glu Ser Pro Pro 
305                 310                 315                 320 


Gly Ala Glu Ala Val Pro Glu Ala Ala Val Leu Glu Val Ser Glu Pro 
                325                 330                 335     


Pro Ala Glu Ala Val Gly Glu Ala Ser Gly Ser Cys Pro Leu Arg Pro 
            340                 345                 350         


Gly Glu Leu Arg Gly Gly Gly Gly Gly Gly Gln Gly Ala Glu Gly Pro 
        355                 360                 365             


Pro Gly Thr Pro Arg Arg Thr Gly Lys Gly Asn Arg Arg Lys Lys Arg 
    370                 375                 380                 


Ala Ala Gly Arg Gly Ala Leu Ser Arg Gly Gly Asp Ser Ala Pro Leu 
385                 390                 395                 400 


Ser Pro Gly Asp Lys Glu Asp Ala Ser His Gln Glu Ala Leu Gly Asn 
                405                 410                 415     


Leu Pro Ser Pro Ser Glu His Lys Leu Pro Glu Cys His Leu Val Lys 
            420                 425                 430         


Glu Glu Tyr Glu Gly Ser Gly Lys Pro Glu Ser Glu Pro Lys Glu Leu 
        435                 440                 445             


Lys Thr Ala Gly Glu Lys Glu Pro Gln Leu Ser Glu Ala Cys Gly Pro 
    450                 455                 460                 


Thr Glu Glu Gly Ala Gly Glu Arg Glu Leu Glu Gly Pro Gly Leu Leu 
465                 470                 475                 480 


Cys Met Ala Gly His Thr Gly Pro Glu Gly Pro Leu Ser Asp Thr Pro 
                485                 490                 495     


Thr Pro Pro Leu Glu Thr Val Gln Glu Gly Lys Gly Asp Asn Ile Pro 
            500                 505                 510         


Glu Glu Ala Leu Ala Val Ser Val Ser Asp His Pro Asp Val Ala Trp 
        515                 520                 525             


Asp Leu Met Ala Ser Gly Phe Leu Ile Leu Thr Gly Gly Val Asp Gln 
    530                 535                 540                 


Ser Gly Arg Ala Leu Leu Thr Ile Thr Pro Pro Cys Pro Pro Glu Glu 
545                 550                 555                 560 


Pro Pro Pro Ser Arg Asp Thr Leu Asn Thr Thr Leu His Tyr Leu His 
                565                 570                 575     


Ser Leu Leu Arg Pro Asp Leu Gln Thr Leu Gly Leu Ser Val Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Ala Pro Pro Leu Pro Pro Ala Leu Ile Pro Ala Leu 
        595                 600                 605             


Ser Gln Leu Gln Asp Ser Gly Asp Pro Pro Leu Val Gln Arg Leu Leu 
    610                 615                 620                 


Ile Leu Ile His Asp Asp Leu Pro Thr Glu Leu Cys Gly Phe Gln Gly 
625                 630                 635                 640 


Ala Glu Val Leu Ser Glu Asn Asp Leu Lys Arg Val Ala Lys Pro Glu 
                645                 650                 655     


Glu Leu Gln Trp Glu Leu Gly Gly His Arg Asp Pro Ser Pro Ser His 
            660                 665                 670         


Trp Val Glu Ile His Gln Glu Val Val Arg Leu Cys Arg Leu Cys Gln 
        675                 680                 685             


Gly Val Leu Gly Ser Val Arg Gln Ala Ile Glu Glu Leu Glu Gly Ala 
    690                 695                 700                 


Ala Glu Pro Glu Glu Glu Glu Ala Val Gly Met Pro Lys Pro Leu Gln 
705                 710                 715                 720 


Lys Val Leu Ala Asp Pro Arg Leu Thr Ala Leu Gln Arg Asp Gly Gly 
                725                 730                 735     


Ala Ile Leu Met Arg Leu Arg Ser Thr Pro Ser Ser Lys Leu Glu Gly 
            740                 745                 750         


Gln Gly Pro Ala Thr Leu Tyr Gln Glu Val Asp Glu Ala Ile His Gln 
        755                 760                 765             


Leu Val Arg Leu Ser Asn Leu His Val Gln Gln Gln Glu Gln Arg Gln 
    770                 775                 780                 


Cys Leu Arg Arg Leu Gln Gln Val Leu Gln Trp Leu Ser Gly Pro Gly 
785                 790                 795                 800 


Glu Glu Gln Leu Ala Ser Phe Ala Met Pro Gly Asp Thr Leu Ser Ala 
                805                 810                 815     


Leu Gln Glu Thr Glu Leu Arg Phe Arg Ala Phe Ser Ala Glu Val Gln 
            820                 825                 830         


Glu Arg Leu Ala Gln Ala Arg Glu Ala Leu Ala Leu Glu Glu Asn Ala 
        835                 840                 845             


Thr Ser Gln Lys Val Leu Asp Ile Phe Glu Gln Arg Leu Glu Gln Val 
    850                 855                 860                 


Glu Ser Gly Leu His Arg Ala Leu Arg Leu Gln Arg Phe Phe Gln Gln 
865                 870                 875                 880 


Ala His Glu Trp Val Asp Glu Gly Phe Ala Arg Leu Ala Gly Ala Gly 
                885                 890                 895     


Pro Gly Arg Glu Ala Val Leu Ala Ala Leu Ala Leu Arg Arg Ala Pro 
            900                 905                 910         


Glu Pro Ser Ala Gly Thr Phe Gln Glu Met Arg Ala Leu Ala Leu Asp 
        915                 920                 925             


Leu Gly Ser Pro Ala Ala Leu Arg Glu Trp Gly Arg Cys Gln Ala Arg 
    930                 935                 940                 


Cys Gln Glu Leu Glu Arg Arg Ile Gln Gln His Val Gly Glu Glu Ala 
945                 950                 955                 960 


Ser Pro Arg Gly Tyr Arg Arg Arg Arg Ala Asp Gly Ala Ser Ser Gly 
                965                 970                 975     


Gly Ala Gln Trp Gly Pro Arg Ser Pro Ser Pro Ser Leu Ser Ser Leu 
            980                 985                 990         


Leu Leu Pro Ser Ser Pro Gly Pro  Arg Pro Ala Pro Ser  His Cys Ser 
        995                 1000                 1005             


Leu Ala  Pro Cys Gly Glu Asp  Tyr Glu Glu Glu Gly  Pro Glu Leu 
    1010                 1015                 1020             


Ala Pro  Glu Ala Glu Gly Arg  Pro Pro Arg Ala Val  Leu Ile Arg 
    1025                 1030                 1035             


Gly Leu  Glu Val Thr Ser Thr  Glu Val Val Asp Arg  Thr Cys Ser 
    1040                 1045                 1050             


Pro Arg  Glu His Val Leu Leu  Gly Arg Ala Arg Gly  Pro Asp Gly 
    1055                 1060                 1065             


Pro Trp  Gly Val Gly Thr Pro  Arg Met Glu Arg Lys  Arg Ser Ile 
    1070                 1075                 1080             


Ser Ala  Gln Gln Arg Leu Val  Ser Glu Leu Ile Ala  Cys Glu Gln 
    1085                 1090                 1095             


Asp Tyr  Val Ala Thr Leu Ser  Glu Pro Val Pro Pro  Pro Gly Pro 
    1100                 1105                 1110             


Glu Leu  Thr Pro Glu Leu Arg  Gly Thr Trp Ala Ala  Ala Leu Ser 
    1115                 1120                 1125             


Ala Arg  Glu Arg Leu Arg Ser  Phe His Arg Thr His  Phe Leu Arg 
    1130                 1135                 1140             


Glu Leu  Gln Gly Cys Ala Thr  His Pro Leu Arg Ile  Gly Ala Cys 
    1145                 1150                 1155             


Phe Leu  Arg His Gly Asp Gln  Phe Ser Leu Tyr Ala  Gln Tyr Val 
    1160                 1165                 1170             


Lys His  Arg His Lys Leu Glu  Asn Gly Leu Ala Ala  Leu Ser Pro 
    1175                 1180                 1185             


Leu Ser  Lys Gly Ser Met Glu  Ala Gly Pro Tyr Leu  Pro Arg Ala 
    1190                 1195                 1200             


Leu Gln  Gln Pro Leu Glu Gln  Leu Thr Arg Tyr Gly  Arg Leu Leu 
    1205                 1210                 1215             


Glu Glu  Leu Leu Arg Glu Ala  Gly Pro Glu Leu Ser  Ser Glu Cys 
    1220                 1225                 1230             


Arg Ala  Leu Gly Ala Ala Val  Gln Leu Leu Arg Glu  Gln Glu Ala 
    1235                 1240                 1245             


Arg Gly  Arg Asp Leu Leu Ala  Val Glu Ala Val Arg  Gly Cys Glu 
    1250                 1255                 1260             


Ile Asp  Leu Lys Glu Gln Gly  Gln Leu Leu His Arg  Asp Pro Phe 
    1265                 1270                 1275             


Thr Val  Ile Cys Gly Arg Lys  Lys Cys Leu Arg His  Val Phe Leu 
    1280                 1285                 1290             


Phe Glu  His Leu Leu Leu Phe  Ser Lys Leu Lys Gly  Pro Glu Gly 
    1295                 1300                 1305             


Gly Ser  Glu Met Phe Val Tyr  Lys Gln Ala Phe Lys  Thr Ala Asp 
    1310                 1315                 1320             


Met Gly  Leu Thr Glu Asn Ile  Gly Asp Ser Gly Leu  Cys Phe Glu 
    1325                 1330                 1335             


Leu Trp  Phe Arg Arg Arg Arg  Ala Arg Glu Ala Tyr  Thr Leu Gln 
    1340                 1345                 1350             


Ala Thr  Ser Pro Glu Ile Lys  Leu Lys Trp Thr Ser  Ser Ile Ala 
    1355                 1360                 1365             


Gln Leu  Leu Trp Arg Gln Ala  Ala His Asn Lys Glu  Leu Arg Val 
    1370                 1375                 1380             


Gln Gln  Met Val Ser Met Gly  Ile Gly Asn Lys Pro  Phe Leu Asp 
    1385                 1390                 1395             


Ile Lys  Ala Leu Gly Glu Arg  Thr Leu Ser Ala Leu  Leu Thr Gly 
    1400                 1405                 1410             


Arg Ala  Pro Glu Thr Leu Asp  Ser Ser Gly Asp Val  Ser Pro Gly 
    1415                 1420                 1425             


Pro Arg  Asn Ser Pro Ser Leu  Gln Pro Pro His Pro  Gly Ser Ser 
    1430                 1435                 1440             


Thr Pro  Thr Leu Ala Ser Arg  Gly Ile Leu Gly Leu  Ser Arg Gln 
    1445                 1450                 1455             


Ser His  Ala Arg Ala Leu Ser  Asp Pro Thr Thr Pro  Leu 
    1460                 1465                 1470     


<210> 5183
<211> 1519
<212> PRT
<213> Homo sapiens

<400> 5183
Met Glu Pro Glu Pro Val Glu Asp Cys Val Gln Ser Thr Leu Ala Ala 
1               5                   10                  15      


Leu Tyr Pro Pro Phe Glu Ala Thr Ala Pro Thr Leu Leu Gly Gln Val 
            20                  25                  30          


Phe Gln Val Val Glu Arg Thr Tyr Arg Glu Asp Ala Leu Arg Tyr Thr 
        35                  40                  45              


Leu Asp Phe Leu Val Pro Ala Lys His Leu Leu Ala Lys Val Gln Gln 
    50                  55                  60                  


Glu Ala Cys Ala Gln Tyr Ser Gly Phe Leu Phe Phe His Glu Gly Trp 
65                  70                  75                  80  


Pro Leu Cys Leu His Glu Gln Val Val Val Gln Leu Ala Ala Leu Pro 
                85                  90                  95      


Trp Gln Leu Leu Arg Pro Gly Asp Phe Tyr Leu Gln Val Val Pro Ser 
            100                 105                 110         


Ala Ala Gln Ala Pro Arg Leu Ala Leu Lys Cys Leu Ala Pro Gly Gly 
        115                 120                 125             


Gly Arg Val Gln Glu Val Pro Val Pro Asn Glu Ala Cys Ala Tyr Leu 
    130                 135                 140                 


Phe Thr Pro Glu Trp Leu Gln Gly Ile Asn Lys Asp Arg Pro Thr Gly 
145                 150                 155                 160 


Arg Leu Ser Thr Cys Leu Leu Ser Ala Pro Ser Gly Ile Gln Arg Leu 
                165                 170                 175     


Pro Trp Ala Glu Leu Ile Cys Pro Arg Phe Val His Lys Glu Gly Leu 
            180                 185                 190         


Met Val Gly His Gln Pro Ser Thr Leu Pro Pro Glu Leu Pro Ser Gly 
        195                 200                 205             


Pro Pro Gly Leu Pro Ser Pro Pro Leu Pro Glu Glu Ala Leu Gly Thr 
    210                 215                 220                 


Arg Ser Pro Gly Asp Gly His Asn Ala Pro Val Glu Gly Pro Glu Gly 
225                 230                 235                 240 


Glu Tyr Val Glu Leu Leu Glu Val Thr Leu Pro Val Arg Gly Ser Pro 
                245                 250                 255     


Thr Asp Ala Glu Gly Ser Pro Gly Leu Ser Arg Val Arg Thr Val Pro 
            260                 265                 270         


Thr Arg Lys Gly Ala Gly Gly Lys Gly Arg His Arg Arg His Arg Ala 
        275                 280                 285             


Trp Met His Gln Lys Gly Leu Gly Pro Arg Gly Gln Asp Gly Ala Arg 
    290                 295                 300                 


Pro Pro Gly Glu Gly Ser Ser Thr Gly Ala Ser Pro Glu Ser Pro Pro 
305                 310                 315                 320 


Gly Ala Glu Ala Val Pro Glu Ala Ala Val Leu Glu Val Ser Glu Pro 
                325                 330                 335     


Pro Ala Glu Ala Val Gly Glu Ala Ser Gly Ser Cys Pro Leu Arg Pro 
            340                 345                 350         


Gly Glu Leu Arg Gly Gly Gly Gly Gly Gly Gln Gly Ala Glu Gly Pro 
        355                 360                 365             


Pro Gly Thr Pro Arg Arg Thr Gly Lys Gly Asn Arg Arg Lys Lys Arg 
    370                 375                 380                 


Ala Ala Gly Arg Gly Ala Leu Ser Arg Gly Gly Asp Ser Ala Pro Leu 
385                 390                 395                 400 


Ser Pro Gly Asp Lys Glu Asp Ala Ser His Gln Glu Ala Leu Gly Asn 
                405                 410                 415     


Leu Pro Ser Pro Ser Glu His Lys Leu Pro Glu Cys His Leu Val Lys 
            420                 425                 430         


Glu Glu Tyr Glu Gly Ser Gly Lys Pro Glu Ser Glu Pro Lys Glu Leu 
        435                 440                 445             


Lys Thr Ala Gly Glu Lys Glu Pro Gln Leu Ser Glu Ala Cys Gly Pro 
    450                 455                 460                 


Thr Glu Glu Gly Ala Gly Glu Arg Glu Leu Glu Gly Pro Gly Leu Leu 
465                 470                 475                 480 


Cys Met Ala Gly His Thr Gly Pro Glu Gly Pro Leu Ser Asp Thr Pro 
                485                 490                 495     


Thr Pro Pro Leu Glu Thr Val Gln Glu Gly Lys Gly Asp Asn Ile Pro 
            500                 505                 510         


Glu Glu Ala Leu Ala Val Ser Val Ser Asp His Pro Asp Val Ala Trp 
        515                 520                 525             


Asp Leu Met Ala Ser Gly Phe Leu Ile Leu Thr Gly Gly Val Asp Gln 
    530                 535                 540                 


Ser Gly Arg Ala Leu Leu Thr Ile Thr Pro Pro Cys Pro Pro Glu Glu 
545                 550                 555                 560 


Pro Pro Pro Ser Arg Asp Thr Leu Asn Thr Thr Leu His Tyr Leu His 
                565                 570                 575     


Ser Leu Leu Arg Pro Asp Leu Gln Thr Leu Gly Leu Ser Val Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Ala Pro Pro Leu Pro Pro Ala Leu Ile Pro Ala Leu 
        595                 600                 605             


Ser Gln Leu Gln Asp Ser Gly Asp Pro Pro Leu Val Gln Arg Leu Leu 
    610                 615                 620                 


Ile Leu Ile His Asp Asp Leu Pro Thr Glu Leu Cys Gly Phe Gln Gly 
625                 630                 635                 640 


Ala Glu Val Leu Ser Glu Asn Asp Leu Lys Arg Val Ala Lys Pro Glu 
                645                 650                 655     


Glu Leu Gln Trp Glu Leu Gly Gly His Arg Asp Pro Ser Pro Ser His 
            660                 665                 670         


Trp Val Glu Ile His Gln Glu Val Val Arg Leu Cys Arg Leu Cys Gln 
        675                 680                 685             


Gly Val Leu Gly Ser Val Arg Gln Ala Ile Glu Glu Leu Glu Gly Ala 
    690                 695                 700                 


Ala Glu Pro Glu Glu Glu Glu Ala Val Gly Met Pro Lys Pro Leu Gln 
705                 710                 715                 720 


Lys Val Leu Ala Asp Pro Arg Leu Thr Ala Leu Gln Arg Asp Gly Gly 
                725                 730                 735     


Ala Ile Leu Met Arg Leu Arg Ser Thr Pro Ser Ser Lys Leu Glu Gly 
            740                 745                 750         


Gln Gly Pro Ala Thr Leu Tyr Gln Glu Val Asp Glu Ala Ile His Gln 
        755                 760                 765             


Leu Val Arg Leu Ser Asn Leu His Val Gln Gln Gln Glu Gln Arg Gln 
    770                 775                 780                 


Cys Leu Arg Arg Leu Gln Gln Val Leu Gln Trp Leu Ser Gly Pro Gly 
785                 790                 795                 800 


Glu Glu Gln Leu Ala Ser Phe Ala Met Pro Gly Asp Thr Leu Ser Ala 
                805                 810                 815     


Leu Gln Glu Thr Glu Leu Arg Phe Arg Ala Phe Ser Ala Glu Val Gln 
            820                 825                 830         


Glu Arg Leu Ala Gln Ala Arg Glu Ala Leu Ala Leu Glu Glu Asn Ala 
        835                 840                 845             


Thr Ser Gln Lys Val Leu Asp Ile Phe Glu Gln Arg Leu Glu Gln Val 
    850                 855                 860                 


Glu Ser Gly Leu His Arg Ala Leu Arg Leu Gln Arg Phe Phe Gln Gln 
865                 870                 875                 880 


Ala His Glu Trp Val Asp Glu Gly Phe Ala Arg Leu Ala Gly Ala Gly 
                885                 890                 895     


Pro Gly Arg Glu Ala Val Leu Ala Ala Leu Ala Leu Arg Arg Ala Pro 
            900                 905                 910         


Glu Pro Ser Ala Gly Thr Phe Gln Glu Met Arg Ala Leu Ala Leu Asp 
        915                 920                 925             


Leu Gly Ser Pro Ala Ala Leu Arg Glu Trp Gly Arg Cys Gln Ala Arg 
    930                 935                 940                 


Cys Gln Glu Leu Glu Arg Arg Ile Gln Gln His Val Gly Glu Glu Ala 
945                 950                 955                 960 


Ser Pro Arg Gly Tyr Arg Arg Arg Arg Ala Asp Gly Ala Ser Ser Gly 
                965                 970                 975     


Gly Ala Gln Trp Gly Pro Arg Ser Pro Ser Pro Ser Leu Ser Ser Leu 
            980                 985                 990         


Leu Leu Pro Ser Ser Pro Gly Pro  Arg Pro Ala Pro Ser  His Cys Ser 
        995                 1000                 1005             


Leu Ala  Pro Cys Gly Glu Asp  Tyr Glu Glu Glu Gly  Pro Glu Leu 
    1010                 1015                 1020             


Ala Pro  Glu Ala Glu Gly Arg  Pro Pro Arg Ala Val  Leu Ile Arg 
    1025                 1030                 1035             


Gly Leu  Glu Val Thr Ser Thr  Glu Val Val Asp Arg  Thr Cys Ser 
    1040                 1045                 1050             


Pro Arg  Glu His Val Leu Leu  Gly Arg Ala Arg Gly  Pro Asp Gly 
    1055                 1060                 1065             


Pro Trp  Gly Val Gly Thr Pro  Arg Met Glu Arg Lys  Arg Ser Ile 
    1070                 1075                 1080             


Ser Ala  Gln Gln Arg Leu Val  Ser Glu Leu Ile Ala  Cys Glu Gln 
    1085                 1090                 1095             


Asp Tyr  Val Ala Thr Leu Ser  Glu Pro Val Pro Pro  Pro Gly Pro 
    1100                 1105                 1110             


Glu Leu  Thr Pro Glu Leu Arg  Gly Thr Trp Ala Ala  Ala Leu Ser 
    1115                 1120                 1125             


Ala Arg  Glu Arg Leu Arg Ser  Phe His Arg Thr His  Phe Leu Arg 
    1130                 1135                 1140             


Glu Leu  Gln Gly Cys Ala Thr  His Pro Leu Arg Ile  Gly Ala Cys 
    1145                 1150                 1155             


Phe Leu  Arg His Gly Asp Gln  Phe Ser Leu Tyr Ala  Gln Tyr Val 
    1160                 1165                 1170             


Lys His  Arg His Lys Leu Glu  Asn Gly Leu Ala Ala  Leu Ser Pro 
    1175                 1180                 1185             


Leu Ser  Lys Gly Ser Met Glu  Ala Gly Pro Tyr Leu  Pro Arg Ala 
    1190                 1195                 1200             


Leu Gln  Gln Pro Leu Glu Gln  Leu Thr Arg Tyr Gly  Arg Leu Leu 
    1205                 1210                 1215             


Glu Glu  Leu Leu Arg Glu Ala  Gly Pro Glu Leu Ser  Ser Glu Cys 
    1220                 1225                 1230             


Arg Ala  Leu Gly Ala Ala Val  Gln Leu Leu Arg Glu  Gln Glu Ala 
    1235                 1240                 1245             


Arg Gly  Arg Asp Leu Leu Ala  Val Glu Ala Val Arg  Gly Cys Glu 
    1250                 1255                 1260             


Ile Asp  Leu Lys Glu Gln Gly  Gln Leu Leu His Arg  Asp Pro Phe 
    1265                 1270                 1275             


Thr Val  Ile Cys Gly Arg Lys  Lys Cys Leu Arg His  Val Phe Leu 
    1280                 1285                 1290             


Phe Glu  His Leu Leu Leu Phe  Ser Lys Leu Lys Gly  Pro Glu Gly 
    1295                 1300                 1305             


Gly Ser  Glu Met Phe Val Tyr  Lys Gln Ala Phe Lys  Thr Ala Asp 
    1310                 1315                 1320             


Met Gly  Leu Thr Glu Asn Ile  Gly Asp Ser Gly Leu  Cys Phe Glu 
    1325                 1330                 1335             


Leu Trp  Phe Arg Arg Arg Arg  Ala Arg Glu Ala Tyr  Thr Leu Gln 
    1340                 1345                 1350             


Ala Thr  Ser Pro Glu Ile Lys  Leu Lys Trp Thr Ser  Ser Ile Ala 
    1355                 1360                 1365             


Gln Leu  Leu Trp Arg Gln Ala  Ala His Asn Lys Glu  Leu Arg Val 
    1370                 1375                 1380             


Gln Gln  Met Val Ser Met Gly  Ile Gly Asn Lys Pro  Phe Leu Asp 
    1385                 1390                 1395             


Ile Lys  Ala Leu Gly Glu Arg  Thr Leu Ser Ala Leu  Leu Thr Gly 
    1400                 1405                 1410             


Arg Ala  Ala Arg Thr Arg Ala  Ser Val Ala Val Ser  Ser Phe Glu 
    1415                 1420                 1425             


His Ala  Gly Pro Ser Leu Pro  Gly Leu Ser Pro Gly  Ala Cys Ser 
    1430                 1435                 1440             


Leu Pro  Ala Arg Val Glu Glu  Glu Ala Trp Asp Leu  Asp Val Lys 
    1445                 1450                 1455             


Gln Ile  Ser Leu Ala Pro Glu  Thr Leu Asp Ser Ser  Gly Asp Val 
    1460                 1465                 1470             


Ser Pro  Gly Pro Arg Asn Ser  Pro Ser Leu Gln Pro  Pro His Pro 
    1475                 1480                 1485             


Gly Ser  Ser Thr Pro Thr Leu  Ala Ser Arg Gly Ile  Leu Gly Leu 
    1490                 1495                 1500             


Ser Arg  Gln Ser His Ala Arg  Ala Leu Ser Asp Pro  Thr Thr Pro 
    1505                 1510                 1515             


Leu 
    


<210> 5184
<211> 902
<212> PRT
<213> Homo sapiens

<400> 5184
Met Phe Pro Ala Leu Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Glu Asp Phe Met Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys 
            20                  25                  30          


Ala Gln Arg Gly Ser Leu Pro Asn Ser Ala Thr His Gln His Val Arg 
        35                  40                  45              


Lys Asn Asn Pro Gln Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp 
    50                  55                  60                  


Asp Leu Ile Pro Asp Thr Leu Gln Lys Glu Lys Leu Leu Trp Pro Ile 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Val His Arg Gln Ile Glu Ala Ile Asn Arg Asp 
                85                  90                  95      


Phe His Ser Cys Leu Gly Trp Met Gln Trp Arg Gly Leu Ser Ser Leu 
            100                 105                 110         


Gln Pro Pro Pro Pro Arg Phe Lys Asp Ser Pro Ala Ser Ala Phe Arg 
        115                 120                 125             


Val Ala Gly Ile Thr Asp Ser His Met Leu Ser Leu Pro His Leu Arg 
    130                 135                 140                 


Ser Arg Gln Leu Leu Tyr Asp Glu Leu Asp Glu Val Asn Pro Arg Leu 
145                 150                 155                 160 


Arg Glu Pro Gln Glu Leu Phe Ser Ile Leu Ser Thr Lys Arg Pro Leu 
                165                 170                 175     


Gln Ala Pro Arg Trp Pro Ile Glu Cys Glu Val Ile Lys Glu Asn Ile 
            180                 185                 190         


His His Ile Glu Trp Ala Pro Pro Gln Pro Glu Tyr Phe Tyr Gln Pro 
        195                 200                 205             


Lys Gly Asn Glu Lys Val Pro Glu Ile Val Gly Glu Lys Lys Gly Thr 
    210                 215                 220                 


Val Val Tyr Gln Leu Asp Ser Val Pro Ile Glu Gly Ser Tyr Phe Thr 
225                 230                 235                 240 


Ser Ser Arg Val Gly Gly Lys Arg Gly Ile Val Lys Glu Leu Ala Val 
                245                 250                 255     


Thr Leu Gln Gly Pro Glu Asp Asn Thr Leu Leu Phe Glu Ser Arg Phe 
            260                 265                 270         


Glu Ser Gly Asn Leu Gln Lys Ala Val Arg Val Asp Thr Tyr Glu Tyr 
        275                 280                 285             


Glu Leu Thr Leu Arg Thr Asp Leu Tyr Thr Asn Lys His Thr Gln Trp 
    290                 295                 300                 


Phe Tyr Phe Arg Val Gln Asn Thr Arg Lys Asp Ala Thr Tyr Arg Phe 
305                 310                 315                 320 


Thr Ile Val Asn Leu Leu Lys Pro Lys Ser Leu Tyr Thr Val Gly Met 
                325                 330                 335     


Lys Pro Leu Leu Tyr Ser Gln Leu Asp Ala Asn Thr Arg Asn Ile Gly 
            340                 345                 350         


Trp Arg Arg Glu Gly Asn Glu Ile Lys Tyr Tyr Lys Asn Asn Thr Asp 
        355                 360                 365             


Asp Gly Gln Gln Pro Phe Tyr Cys Leu Thr Trp Thr Ile Gln Phe Pro 
    370                 375                 380                 


Tyr Asp Gln Asp Thr Cys Phe Phe Ala His Phe Tyr Pro Tyr Thr Tyr 
385                 390                 395                 400 


Thr Asp Leu Gln Cys Tyr Leu Leu Ser Val Ala Asn Asn Pro Ile Gln 
                405                 410                 415     


Ser Gln Phe Cys Lys Leu Gln Thr Leu Cys Arg Ser Leu Ala Gly Asn 
            420                 425                 430         


Thr Val Tyr Leu Leu Thr Ile Thr Asn Pro Ser Gln Thr Pro Gln Glu 
        435                 440                 445             


Ala Ala Ala Lys Lys Ala Val Val Leu Ser Ala Arg Val His Pro Gly 
    450                 455                 460                 


Glu Ser Asn Gly Ser Trp Val Met Lys Gly Phe Leu Asp Phe Ile Leu 
465                 470                 475                 480 


Ser Asn Ser Pro Asp Ala Gln Leu Leu Arg Asp Ile Phe Val Phe Lys 
                485                 490                 495     


Val Leu Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg 
            500                 505                 510         


Cys Ser Leu Ala Gly Arg Asp Leu Asn Arg His Tyr Lys Thr Ile Leu 
        515                 520                 525             


Lys Glu Ser Phe Pro Cys Ile Trp Tyr Thr Arg Asn Met Ile Lys Arg 
    530                 535                 540                 


Leu Leu Glu Glu Arg Glu Val Leu Leu Tyr Cys Asp Phe His Gly His 
545                 550                 555                 560 


Ser Arg Lys Asn Asn Ile Phe Leu Tyr Gly Cys Asn Asn Asn Asn Arg 
                565                 570                 575     


Lys Tyr Trp Leu His Glu Arg Val Phe Pro Leu Met Leu Cys Lys Asn 
            580                 585                 590         


Ala Pro Asp Lys Phe Ser Phe His Ser Cys Asn Phe Lys Val Gln Lys 
        595                 600                 605             


Cys Lys Glu Gly Thr Gly Arg Val Val Met Trp Arg Met Gly Ile Leu 
    610                 615                 620                 


Asn Ser Tyr Thr Met Glu Ser Thr Phe Gly Gly Ser Thr Leu Gly Asn 
625                 630                 635                 640 


Lys Arg Asp Thr His Phe Thr Ile Glu Asp Leu Lys Ser Leu Gly Tyr 
                645                 650                 655     


His Val Cys Asp Thr Leu Leu Asp Phe Cys Asp Pro Asp Gln Met Lys 
            660                 665                 670         


Phe Thr Gln Cys Leu Ala Glu Leu Lys Glu Leu Leu Arg Gln Glu Ile 
        675                 680                 685             


His Lys Lys Phe His Glu Leu Gly Gln Asp Val Asp Leu Glu Gly Ser 
    690                 695                 700                 


Trp Ser Asp Ile Ser Leu Ser Asp Ile Glu Ser Ser Thr Ser Gly Ser 
705                 710                 715                 720 


Asp Ser Ser Leu Ser Asp Gly Leu Pro Val His Leu Ala Asn Ile Ala 
                725                 730                 735     


Asp Glu Leu Thr Gln Lys Lys Lys Met Phe Lys Lys Lys Lys Lys Lys 
            740                 745                 750         


Ser Leu Gln Thr Arg Lys Gln Arg Asn Glu Gln Tyr Gln Lys Lys Asn 
        755                 760                 765             


Leu Met Gln Lys Leu Lys Leu Thr Glu Asp Thr Ser Glu Lys Ala Gly 
    770                 775                 780                 


Phe Ala Ser Thr Leu Gln Lys Gln Pro Thr Phe Phe Lys Asn Ser Glu 
785                 790                 795                 800 


Asn Ser Ser Phe Leu Pro Met Lys Asn Glu Asn Pro Arg Leu Asn Glu 
                805                 810                 815     


Thr Asn Leu Asn Arg Arg Asp Lys Asp Thr Pro Leu Asp Pro Ser Met 
            820                 825                 830         


Ala Thr Leu Ile Leu Pro Lys Asn Lys Gly Arg Met Gln Asn Lys Lys 
        835                 840                 845             


Pro Gly Phe Thr Val Ser Cys Ser Pro Lys Arg Thr Ile Asn Ser Ser 
    850                 855                 860                 


Gln Glu Pro Ala Pro Gly Met Lys Pro Asn Trp Pro Arg Ser Arg Tyr 
865                 870                 875                 880 


Pro Ala Thr Lys Arg Gly Cys Ala Ala Met Ala Ala Tyr Pro Ser Leu 
                885                 890                 895     


His Ile Tyr Thr Tyr Pro 
            900         


<210> 5185
<211> 1077
<212> PRT
<213> Homo sapiens

<400> 5185
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Thr Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Thr Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Thr Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Thr Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Thr Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Thr Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Thr Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Thr Thr Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys 
        435                 440                 445             


Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro 
            500                 505                 510         


Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser 
        515                 520                 525             


Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Thr 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Thr Ser Ser Pro Val Thr 
        675                 680                 685             


Cys Ser Ser Asn Ala Cys Leu Val Thr Thr Asp Gln Ala Ser Ser Gly 
    690                 695                 700                 


Ser Glu Thr Glu Phe Met Thr Ser Glu Thr Pro Glu Val Phe Asn Val 
705                 710                 715                 720 


Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro 
                725                 730                 735     


Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln Thr 
            740                 745                 750         


Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Thr Val His 
        755                 760                 765             


Ser Gln Glu Thr Ala Asn Tyr His Pro Asp Gly Thr Ile Gln Val Ser 
    770                 775                 780                 


Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Thr Asn Val Phe Pro Arg 
785                 790                 795                 800 


Pro Thr Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg Gly Cys Thr 
                805                 810                 815     


Arg Gly Gly Arg Leu Ile Thr Asn Ser Tyr Arg Ser Pro Gly Gly Tyr 
            820                 825                 830         


Lys Gly Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile Ser Asn Gly Asn 
        835                 840                 845             


Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala Pro Tyr 
    850                 855                 860                 


Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg Gly Gly Thr Ser 
865                 870                 875                 880 


Gly Gly Pro Arg Ala Asn Ser Arg Ala Gly Trp Ser Asp Ser Ser Gln 
                885                 890                 895     


Val Ser Ser Pro Glu Arg Asp Asn Glu Thr Phe Asn Ser Gly Asp Ser 
            900                 905                 910         


Gly Gln Gly Asp Ser Arg Ser Met Thr Pro Val Asp Val Pro Val Thr 
        915                 920                 925             


Asn Pro Ala Ala Thr Ile Leu Pro Val His Val Tyr Pro Leu Pro Gln 
    930                 935                 940                 


Gln Met Arg Val Ala Phe Ser Ala Ala Arg Thr Ser Asn Leu Ala Pro 
945                 950                 955                 960 


Gly Thr Leu Asp Gln Pro Ile Val Phe Asp Leu Leu Leu Asn Asn Leu 
                965                 970                 975     


Gly Glu Thr Phe Asp Leu Gln Leu Gly Arg Phe Asn Cys Pro Val Asn 
            980                 985                 990         


Gly Thr Tyr Val Phe Ile Phe His  Met Leu Lys Leu Ala  Val Asn Val 
        995                 1000                 1005             


Pro Leu  Tyr Val Asn Leu Met  Lys Asn Glu Glu Val  Leu Val Ser 
    1010                 1015                 1020             


Ala Tyr  Ala Asn Asp Gly Ala  Pro Asp His Glu Thr  Ala Ser Asn 
    1025                 1030                 1035             


His Ala  Ile Leu Gln Leu Phe  Gln Gly Asp Gln Ile  Trp Leu Arg 
    1040                 1045                 1050             


Leu His  Arg Gly Ala Ile Tyr  Gly Ser Ser Trp Lys  Tyr Ser Thr 
    1055                 1060                 1065             


Phe Ser  Gly Tyr Leu Leu Tyr  Gln Asp 
    1070                 1075         


<210> 5186
<211> 351
<212> PRT
<213> Homo sapiens

<400> 5186
Met Thr Leu Arg Leu Leu Glu Asp Trp Cys Arg Gly Met Asp Met Asn 
1               5                   10                  15      


Pro Arg Lys Ala Leu Leu Ile Ala Gly Ile Ser Gln Ser Cys Ser Val 
            20                  25                  30          


Ala Glu Ile Glu Glu Ala Leu Gln Ala Gly Leu Ala Pro Leu Gly Glu 
        35                  40                  45              


Tyr Arg Leu Leu Gly Arg Met Phe Arg Arg Asp Glu Asn Arg Lys Val 
    50                  55                  60                  


Ala Leu Val Gly Leu Thr Ala Glu Thr Ser His Ala Leu Val Pro Lys 
65                  70                  75                  80  


Glu Ile Pro Gly Lys Gly Gly Ile Trp Arg Val Ile Phe Lys Pro Pro 
                85                  90                  95      


Asp Pro Asp Asn Thr Phe Leu Ser Arg Leu Asn Glu Phe Leu Ala Gly 
            100                 105                 110         


Glu Gly Met Thr Val Gly Glu Leu Ser Arg Ala Leu Gly His Glu Asn 
        115                 120                 125             


Gly Ser Leu Asp Pro Glu Gln Gly Met Ile Pro Glu Met Trp Ala Pro 
    130                 135                 140                 


Met Leu Ala Gln Ala Leu Glu Ala Leu Gln Pro Ala Leu Gln Cys Leu 
145                 150                 155                 160 


Lys Tyr Lys Lys Leu Arg Val Phe Ser Gly Arg Glu Ser Pro Glu Pro 
                165                 170                 175     


Gly Glu Glu Glu Phe Gly Arg Trp Met Phe His Thr Thr Gln Met Ile 
            180                 185                 190         


Lys Ala Trp Gln Val Pro Asp Val Glu Lys Arg Arg Arg Leu Leu Glu 
        195                 200                 205             


Ser Leu Arg Gly Pro Ala Leu Asp Val Ile Arg Val Leu Lys Ile Asn 
    210                 215                 220                 


Asn Pro Leu Ile Thr Val Asp Glu Cys Leu Gln Ala Leu Glu Glu Val 
225                 230                 235                 240 


Phe Gly Val Thr Asp Asn Pro Arg Glu Leu Gln Val Lys Tyr Leu Thr 
                245                 250                 255     


Thr Tyr Gln Lys Asp Glu Glu Lys Leu Ser Ala Tyr Val Leu Arg Leu 
            260                 265                 270         


Glu Pro Leu Leu Gln Lys Leu Val Gln Arg Gly Ala Ile Glu Arg Asp 
        275                 280                 285             


Ala Val Asn Gln Ala Arg Leu Asp Gln Val Ile Ala Gly Ala Val His 
    290                 295                 300                 


Lys Thr Ile Arg Arg Glu Leu Asn Leu Pro Glu Asp Gly Pro Ala Pro 
305                 310                 315                 320 


Gly Phe Leu Gln Leu Leu Val Leu Ile Lys Asp Tyr Glu Ala Ala Glu 
                325                 330                 335     


Glu Glu Glu Ala Leu Leu Gln Ala Ile Leu Glu Gly Asn Phe Thr 
            340                 345                 350     


<210> 5187
<211> 852
<212> PRT
<213> Homo sapiens

<400> 5187
Met Ser Gly Arg Ala Arg Val Lys Ala Arg Gly Ile Ala Arg Ser Pro 
1               5                   10                  15      


Ser Ala Thr Glu Val Gly Arg Ile Gln Ala Ser Pro Leu Pro Arg Ser 
            20                  25                  30          


Val Asp Leu Ser Asn Asn Glu Ala Ser Ser Ser Asn Gly Phe Leu Gly 
        35                  40                  45              


Thr Ser Arg Ile Ser Thr Asn Asp Lys Tyr Gly Ile Ser Ser Gly Asp 
    50                  55                  60                  


Ala Gly Ser Thr Phe Met Glu Arg Gly Val Lys Asn Lys Gln Asp Phe 
65                  70                  75                  80  


Met Asp Leu Ser Ile Cys Thr Arg Glu Lys Leu Ala His Val Arg Asn 
                85                  90                  95      


Cys Lys Thr Gly Ser Ser Gly Ile Pro Val Lys Leu Val Thr Asn Leu 
            100                 105                 110         


Phe Asn Leu Asp Phe Pro Gln Asp Trp Gln Leu Tyr Gln Tyr His Val 
        115                 120                 125             


Thr Tyr Ile Pro Asp Leu Ala Ser Arg Arg Leu Arg Ile Ala Leu Leu 
    130                 135                 140                 


Tyr Ser His Ser Glu Leu Ser Asn Lys Ala Lys Ala Phe Asp Gly Ala 
145                 150                 155                 160 


Ile Leu Phe Leu Ser Gln Lys Leu Glu Glu Lys Val Thr Glu Leu Ser 
                165                 170                 175     


Ser Glu Thr Gln Arg Gly Glu Thr Ile Lys Met Thr Ile Thr Leu Lys 
            180                 185                 190         


Arg Glu Leu Pro Ser Ser Ser Pro Val Cys Ile Gln Val Phe Asn Ile 
        195                 200                 205             


Ile Phe Arg Lys Ile Leu Lys Lys Leu Ser Met Tyr Gln Ile Gly Arg 
    210                 215                 220                 


Asn Phe Tyr Asn Pro Ser Glu Pro Met Glu Ile Pro Gln His Lys Leu 
225                 230                 235                 240 


Ser Leu Trp Pro Gly Phe Ala Ile Ser Val Ser Tyr Phe Glu Arg Lys 
                245                 250                 255     


Leu Leu Phe Ser Ala Asp Val Ser Tyr Lys Val Leu Arg Asn Glu Thr 
            260                 265                 270         


Val Leu Glu Phe Met Thr Ala Leu Cys Gln Arg Thr Gly Leu Ser Cys 
        275                 280                 285             


Phe Thr Gln Thr Cys Glu Lys Gln Leu Ile Gly Leu Ile Val Leu Thr 
    290                 295                 300                 


Arg Tyr Asn Asn Arg Thr Tyr Ser Ile Asp Asp Ile Asp Trp Ser Val 
305                 310                 315                 320 


Lys Pro Thr His Thr Phe Gln Lys Arg Asp Gly Thr Glu Ile Thr Tyr 
                325                 330                 335     


Val Asp Tyr Tyr Lys Gln Gln Tyr Asp Ile Thr Val Ser Asp Leu Asn 
            340                 345                 350         


Gln Pro Met Leu Val Ser Leu Leu Lys Lys Lys Arg Asn Asp Asn Ser 
        355                 360                 365             


Glu Ala Gln Leu Ala His Leu Ile Pro Glu Leu Cys Phe Leu Thr Gly 
    370                 375                 380                 


Leu Thr Asp Gln Ala Thr Ser Asp Phe Gln Leu Met Lys Ala Val Ala 
385                 390                 395                 400 


Glu Lys Thr Arg Leu Ser Pro Ser Gly Arg Gln Gln Arg Leu Ala Arg 
                405                 410                 415     


Leu Val Asp Asn Ile Gln Arg Asn Thr Asn Ala Arg Phe Glu Leu Glu 
            420                 425                 430         


Thr Trp Gly Leu His Phe Gly Ser Gln Ile Ser Leu Thr Gly Arg Ile 
        435                 440                 445             


Val Pro Ser Glu Lys Ile Leu Met Gln Asp His Ile Cys Gln Pro Val 
    450                 455                 460                 


Ser Ala Ala Asp Trp Ser Lys Asp Ile Arg Thr Cys Lys Ile Leu Asn 
465                 470                 475                 480 


Ala Gln Ser Leu Asn Thr Trp Leu Ile Leu Cys Ser Asp Arg Thr Glu 
                485                 490                 495     


Tyr Val Ala Glu Ser Phe Leu Asn Cys Leu Arg Arg Val Ala Gly Ser 
            500                 505                 510         


Met Gly Phe Asn Val Asp Tyr Pro Lys Ile Ile Lys Val Gln Glu Asn 
        515                 520                 525             


Pro Ala Ala Phe Val Arg Ala Ile Gln Gln Tyr Val Asp Pro Asp Val 
    530                 535                 540                 


Gln Leu Val Met Cys Ile Leu Pro Ser Asn Gln Lys Thr Tyr Tyr Asp 
545                 550                 555                 560 


Ser Ile Lys Lys Tyr Leu Ser Ser Asp Cys Pro Val Pro Ser Gln Cys 
                565                 570                 575     


Val Leu Ala Arg Thr Leu Asn Lys Gln Gly Met Met Met Ser Ile Ala 
            580                 585                 590         


Thr Lys Ile Ala Met Gln Met Thr Cys Lys Leu Gly Gly Glu Leu Trp 
        595                 600                 605             


Ala Val Glu Ile Pro Leu Lys Ser Leu Met Val Val Gly Ile Asp Val 
    610                 615                 620                 


Cys Lys Asp Ala Leu Ser Lys Asp Val Met Val Val Gly Cys Val Ala 
625                 630                 635                 640 


Ser Val Asn Pro Arg Ile Thr Arg Trp Phe Ser Arg Cys Ile Leu Gln 
                645                 650                 655     


Arg Thr Met Thr Asp Val Ala Asp Cys Leu Lys Val Phe Met Thr Gly 
            660                 665                 670         


Ala Leu Asn Lys Trp Tyr Lys Tyr Asn His Asp Leu Pro Ala Arg Ile 
        675                 680                 685             


Ile Val Tyr Arg Ala Gly Val Gly Asp Gly Gln Leu Lys Thr Leu Ile 
    690                 695                 700                 


Glu Tyr Glu Val Pro Gln Leu Leu Ser Ser Val Ala Glu Ser Ser Ser 
705                 710                 715                 720 


Asn Thr Ser Ser Arg Leu Ser Val Ile Val Val Arg Lys Lys Cys Met 
                725                 730                 735     


Pro Arg Phe Phe Thr Glu Met Asn Arg Thr Val Gln Asn Pro Pro Leu 
            740                 745                 750         


Gly Thr Val Val Asp Ser Glu Ala Thr Arg Asn Glu Trp Tyr Asp Phe 
        755                 760                 765             


Tyr Leu Ile Ser Gln Val Ala Cys Arg Gly Thr Val Ser Pro Thr Tyr 
    770                 775                 780                 


Tyr Asn Val Ile Tyr Asp Asp Asn Gly Leu Lys Pro Asp His Met Gln 
785                 790                 795                 800 


Arg Leu Thr Phe Lys Leu Cys His Leu Tyr Tyr Asn Trp Pro Gly Ile 
                805                 810                 815     


Val Ser Val Pro Ala Pro Cys Gln Tyr Ala His Lys Leu Thr Phe Leu 
            820                 825                 830         


Val Ala Gln Ser Ile His Lys Glu Pro Ser Leu Glu Leu Ala Asn His 
        835                 840                 845             


Leu Phe Tyr Leu 
    850         


<210> 5188
<211> 720
<212> PRT
<213> Homo sapiens

<400> 5188
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln Val 
    210                 215                 220                 


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
225                 230                 235                 240 


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
                245                 250                 255     


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
            260                 265                 270         


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
        275                 280                 285             


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
    290                 295                 300                 


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
305                 310                 315                 320 


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
                325                 330                 335     


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
            340                 345                 350         


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
        355                 360                 365             


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
    370                 375                 380                 


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
385                 390                 395                 400 


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
                405                 410                 415     


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
            420                 425                 430         


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
        435                 440                 445             


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
    450                 455                 460                 


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
465                 470                 475                 480 


Glu Leu Glu Ser Leu Phe Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
                485                 490                 495     


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
            500                 505                 510         


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
        515                 520                 525             


Ser Gln Gln Leu Gln Asp Ser Leu Arg Lys Lys Asp Asp Arg Ile Glu 
    530                 535                 540                 


Glu Leu Glu Glu Ala Leu Arg Glu Ser Val Gln Ile Thr Ala Glu Arg 
545                 550                 555                 560 


Glu Met Val Leu Ala Gln Glu Glu Ser Ala Arg Thr Asn Ala Glu Lys 
                565                 570                 575     


Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val Lys Gln Glu Leu 
            580                 585                 590         


Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln Ser Leu Ala Glu 
        595                 600                 605             


Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg Arg Lys His Leu 
    610                 615                 620                 


Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser 
625                 630                 635                 640 


Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser Ser Ser Lys Lys 
                645                 650                 655     


Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu Lys Asp Arg Leu 
            660                 665                 670         


Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala 
        675                 680                 685             


Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His Ser Asn Gln Thr 
    690                 695                 700                 


Asn His Lys Pro Ser Pro Asp Gln Asp Glu Glu Glu Gly Ile Trp Ala 
705                 710                 715                 720 


<210> 5189
<211> 447
<212> PRT
<213> Homo sapiens

<400> 5189
Met Asp Met Gly Asn Gln His Pro Ser Ile Ser Arg Leu Gln Glu Ile 
1               5                   10                  15      


Gln Lys Glu Val Lys Ser Val Glu Gln Gln Val Ile Gly Phe Ser Gly 
            20                  25                  30          


Leu Ser Asp Asp Lys Asn Tyr Lys Lys Leu Glu Arg Ile Leu Thr Lys 
        35                  40                  45              


Gln Leu Phe Glu Ile Asp Ser Val Asp Thr Glu Gly Lys Gly Asp Ile 
    50                  55                  60                  


Gln Gln Ala Arg Lys Arg Ala Ala Gln Glu Thr Glu Arg Leu Leu Lys 
65                  70                  75                  80  


Glu Leu Glu Gln Asn Ala Asn His Pro His Arg Ile Glu Ile Gln Asn 
                85                  90                  95      


Ile Phe Glu Glu Ala Gln Ser Leu Val Arg Glu Lys Ile Val Pro Phe 
            100                 105                 110         


Tyr Asn Gly Gly Asn Cys Val Thr Asp Glu Phe Glu Glu Gly Ile Gln 
        115                 120                 125             


Asp Ile Ile Leu Arg Leu Thr His Val Lys Thr Gly Gly Lys Ile Ser 
    130                 135                 140                 


Leu Arg Lys Ala Arg Tyr His Thr Leu Thr Lys Ile Cys Ala Val Gln 
145                 150                 155                 160 


Glu Ile Ile Glu Asp Cys Met Lys Lys Gln Pro Ser Leu Pro Leu Ser 
                165                 170                 175     


Glu Asp Ala His Pro Ser Val Ala Lys Ile Asn Phe Val Met Cys Glu 
            180                 185                 190         


Val Asn Lys Ala Arg Gly Val Leu Ile Ala Leu Leu Met Gly Val Asn 
        195                 200                 205             


Asn Asn Glu Thr Cys Arg His Leu Ser Cys Val Leu Ser Gly Leu Ile 
    210                 215                 220                 


Ala Asp Leu Asp Ala Leu Asp Val Cys Gly Arg Thr Glu Ile Arg Asn 
225                 230                 235                 240 


Tyr Arg Arg Glu Val Val Glu Asp Ile Asn Lys Leu Leu Lys Tyr Leu 
                245                 250                 255     


Asp Leu Glu Glu Glu Ala Asp Thr Thr Lys Ala Phe Asp Leu Arg Gln 
            260                 265                 270         


Asn His Ser Ile Leu Lys Ile Glu Lys Val Leu Lys Arg Met Arg Glu 
        275                 280                 285             


Ile Lys Asn Glu Leu Leu Gln Ala Gln Asn Pro Ser Glu Leu Tyr Leu 
    290                 295                 300                 


Ser Ser Lys Thr Glu Leu Gln Gly Leu Ile Gly Gln Leu Asp Glu Val 
305                 310                 315                 320 


Ser Leu Glu Lys Asn Pro Cys Ile Arg Glu Ala Arg Arg Arg Ala Val 
                325                 330                 335     


Ile Glu Val Gln Thr Leu Ile Thr Tyr Ile Asp Leu Lys Glu Ala Leu 
            340                 345                 350         


Glu Lys Arg Lys Leu Phe Ala Cys Glu Glu His Pro Ser His Lys Ala 
        355                 360                 365             


Val Trp Asn Val Leu Gly Asn Leu Ser Glu Ile Gln Gly Glu Val Leu 
    370                 375                 380                 


Ser Phe Asp Gly Asn Arg Thr Asp Lys Asn Tyr Ile Arg Leu Glu Glu 
385                 390                 395                 400 


Leu Leu Thr Lys Gln Leu Leu Ala Leu Asp Ala Val Asp Pro Gln Gly 
                405                 410                 415     


Glu Glu Lys Cys Lys Ala Ala Arg Lys Gln Ala Val Arg Leu Ala Gln 
            420                 425                 430         


Asn Ile Leu Ser Tyr Leu Asp Leu Lys Ser Asp Glu Trp Glu Tyr 
        435                 440                 445         


<210> 5190
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5190
Met Ala Gln Ser Gly Gly Glu Ala Arg Pro Gly Pro Lys Thr Ala Val 
1               5                   10                  15      


Gln Ile Arg Val Ala Ile Gln Glu Ala Glu Asp Val Asp Glu Leu Glu 
            20                  25                  30          


Asp Glu Glu Glu Gly Ala Glu Thr Arg Gly Ala Gly Asp Pro Ala Arg 
        35                  40                  45              


Tyr Leu Ser Pro Gly Trp Gly Ser Ala Ser Glu Glu Glu Pro Ser Arg 
    50                  55                  60                  


Gly His Ser Gly Thr Thr Ala Ser Gly Gly Glu Asn Glu Arg Glu Asp 
65                  70                  75                  80  


Leu Glu Gln Glu Trp Lys Pro Pro Asp Glu Glu Leu Ile Lys Lys Leu 
                85                  90                  95      


Val Asp Gln Ile Glu Phe Tyr Phe Ser Asp Glu Asn Leu Glu Lys Asp 
            100                 105                 110         


Ala Phe Leu Leu Lys His Val Arg Arg Asn Lys Leu Gly Tyr Val Ser 
        115                 120                 125             


Val Lys Leu Leu Thr Ser Phe Lys Lys Val Lys His Leu Thr Arg Asp 
    130                 135                 140                 


Trp Arg Thr Thr Ala His Ala Leu Lys Tyr Ser Val Val Leu Glu Leu 
145                 150                 155                 160 


Asn Glu Asp His Arg Lys Val Arg Arg Thr Thr Pro Val Pro Leu Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Pro Ser Lys Met Leu Leu Val Tyr Asp Leu Tyr 
            180                 185                 190         


Leu Ser Pro Lys Leu Trp Ala Leu Ala Thr Pro Gln Lys Asn Gly Arg 
        195                 200                 205             


Val Gln Glu Lys Val Met Glu His Leu Leu Lys Leu Phe Gly Thr Phe 
    210                 215                 220                 


Gly Val Ile Ser Ser Val Arg Ile Leu Lys Pro Gly Arg Glu Leu Pro 
225                 230                 235                 240 


Pro Asp Ile Arg Arg Ile Ser Ser Arg Tyr Ser Gln Val Gly Thr Gln 
                245                 250                 255     


Glu Cys Ala Ile Val Glu Phe Glu Glu Val Glu Ala Ala Ile Lys Ala 
            260                 265                 270         


His Glu Phe Met Ile Thr Glu Ser Gln Gly Lys Glu Asn Met Lys Ala 
        275                 280                 285             


Val Leu Ile Gly Met Lys Pro Pro Lys Lys Lys Pro Ala Lys Asp Lys 
    290                 295                 300                 


Asn His Asp Glu Glu Pro Thr Ala Ser Ile His Leu Asn Lys Ser Leu 
305                 310                 315                 320 


Asn Lys Arg Val Glu Glu Leu Gln Tyr Met Gly Asp Glu Ser Ser Ala 
                325                 330                 335     


Asn Ser Ser Ser Asp Pro Glu Ser Asn Pro Thr Ser Pro Met Ala Gly 
            340                 345                 350         


Arg Arg His Ala Ala Thr Asn Lys Leu Ser Pro Ser Gly His Gln Asn 
        355                 360                 365             


Leu Phe Leu Ser Pro Asn Ala Ser Pro Cys Thr Ser Pro Trp Ser Ser 
    370                 375                 380                 


Pro Leu Ala Gln Arg Lys Gly Val Ser Arg Lys Ser Pro Leu Ala Glu 
385                 390                 395                 400 


Glu Gly Arg Leu Asn Cys Ser Thr Ser Pro Glu Ile Phe Arg Lys Cys 
                405                 410                 415     


Met Asp Tyr Ser Ser Asp Ser Ser Val Thr Pro Ser Gly Ser Pro Trp 
            420                 425                 430         


Val Arg Arg Arg Arg Gln Ala Glu Met Gly Thr Gln Glu Lys Ser Pro 
        435                 440                 445             


Gly Thr Ser Pro Leu Leu Ser Arg Lys Met Gln Thr Ala Asp Gly Leu 
    450                 455                 460                 


Pro Val Gly Val Leu Arg Leu Pro Arg Gly Pro Asp Asn Thr Arg Gly 
465                 470                 475                 480 


Phe His Gly His Glu Arg Ser Arg Ala Cys Val 
                485                 490     


<210> 5191
<211> 104
<212> PRT
<213> Homo sapiens

<400> 5191
Met Ala Gly Lys Ala His Arg Leu Ser Ala Glu Glu Arg Asp Gln Leu 
1               5                   10                  15      


Leu Pro Asn Leu Arg Ala Val Gly Trp Asn Glu Leu Glu Gly Arg Asp 
            20                  25                  30          


Ala Ile Phe Lys Gln Phe His Phe Lys Asp Phe Asn Arg Ala Phe Gly 
        35                  40                  45              


Phe Met Thr Arg Val Ala Leu Gln Ala Glu Lys Leu Asp His His Pro 
    50                  55                  60                  


Glu Trp Phe Asn Val Tyr Asn Lys Val His Ile Thr Leu Ser Thr His 
65                  70                  75                  80  


Glu Cys Ala Gly Leu Ser Glu Arg Asp Ile Asn Leu Ala Ser Phe Ile 
                85                  90                  95      


Glu Gln Val Ala Val Ser Met Thr 
            100                 


<210> 5192
<211> 245
<212> PRT
<213> Homo sapiens

<400> 5192
Met Ile Gly Val Ser Phe Glu Glu Ala Lys Ser Ile Ile Thr Gly Ala 
1               5                   10                  15      


Lys Leu Ser Thr Arg Leu Glu Ser Ala Trp Glu Ile Ala Phe Ile Arg 
            20                  25                  30          


Gln Lys Ser Asp Asn Ile Gln Pro Glu Asn Leu Ser Cys Thr Ser Leu 
        35                  40                  45              


Ile Glu Ala Ser Gly Glu Tyr Gly Pro Gln Ala Ser Thr Leu Ser Leu 
    50                  55                  60                  


Phe Ser Ser Pro Pro Glu Ile Leu Ile Pro Lys Thr Ser Ser Thr Pro 
65                  70                  75                  80  


Lys Thr Asn Asn Asp Ile Leu Ser Ser Cys Glu Ile Lys Thr Gly Tyr 
                85                  90                  95      


Asn Lys Thr Val Gln Ile Pro Ile Thr Ser Glu Asn Ser Thr Val Gly 
            100                 105                 110         


Leu Ser Asn Thr Asp Val Ala Ser Ala Trp Thr Glu Asn Tyr Gly Leu 
        115                 120                 125             


Gln Glu Lys Ile Ser Leu Asn Pro Ser Val Arg Phe Lys Ala Glu Lys 
    130                 135                 140                 


Leu Glu Met Ala Leu Asn Tyr Leu Gly Ile Gln Pro Thr Lys Glu Gln 
145                 150                 155                 160 


His Gln Ala Leu Arg Gln Gln Val Gln Ala Asp Ser Lys Gly Thr Val 
                165                 170                 175     


Ser Phe Gly Asp Phe Val Gln Val Ala Arg Asn Leu Phe Cys Leu Gln 
            180                 185                 190         


Leu Asp Glu Val Asn Val Gly Ala His Glu Ile Ser Asn Ile Leu Asp 
        195                 200                 205             


Ser Gln Leu Leu Pro Cys Asp Ser Ser Glu Ala Asp Glu Met Glu Arg 
    210                 215                 220                 


Leu Lys Cys Glu Arg Asp Asp Ala Leu Lys Glu Val Asn Thr Leu Lys 
225                 230                 235                 240 


Trp Pro Gly Gln Asn 
                245 


<210> 5193
<211> 282
<212> PRT
<213> Homo sapiens

<400> 5193
Met Gly Gly Ala Val Ser Ala Gly Glu Asp Asn Asp Glu Leu Ile Asp 
1               5                   10                  15      


Asn Leu Lys Glu Ala Gln Tyr Ile Arg Thr Glu Leu Val Glu Gln Ala 
            20                  25                  30          


Phe Arg Ala Ile Asp Arg Ala Asp Tyr Tyr Leu Glu Glu Phe Lys Glu 
        35                  40                  45              


Asn Ala Tyr Lys Asp Leu Ala Trp Lys His Gly Asn Ile His Leu Ser 
    50                  55                  60                  


Ala Pro Cys Ile Tyr Ser Glu Val Met Glu Ala Leu Asp Leu Gln Pro 
65                  70                  75                  80  


Gly Leu Ser Phe Leu Asn Leu Gly Ser Gly Thr Gly Tyr Leu Ser Ser 
                85                  90                  95      


Met Val Gly Leu Ile Leu Gly Pro Phe Gly Val Asn His Gly Val Glu 
            100                 105                 110         


Leu His Ser Asp Val Ile Glu Tyr Ala Lys Gln Lys Leu Asp Phe Phe 
        115                 120                 125             


Ile Arg Thr Ser Asp Ser Phe Asp Lys Phe Asp Phe Cys Glu Pro Ser 
    130                 135                 140                 


Phe Val Thr Gly Asn Cys Leu Glu Ile Ser Pro Asp Cys Ser Gln Tyr 
145                 150                 155                 160 


Asp Arg Val Tyr Cys Gly Ala Gly Val Gln Lys Glu His Glu Glu Tyr 
                165                 170                 175     


Met Lys Asn Leu Leu Lys Val Gly Gly Ile Leu Val Met Pro Leu Glu 
            180                 185                 190         


Glu Lys Leu Thr Lys Ile Thr Arg Thr Gly Pro Ser Ala Trp Glu Thr 
        195                 200                 205             


Lys Lys Ile Leu Ala Val Ser Phe Ala Pro Leu Ile Gln Pro Cys His 
    210                 215                 220                 


Ser Glu Ser Gly Lys Ser Arg Leu Val Gln Leu Arg Ser Pro Ser Phe 
225                 230                 235                 240 


Val Gln Gly Trp Ser Val Val Val Leu Ser Gln Leu Thr Ala Ala Ser 
                245                 250                 255     


Thr Phe Gln Ala Glu Ala Ile Leu Pro Ser Gln Ser Pro Thr Trp Leu 
            260                 265                 270         


Thr Leu Gln Val Leu Ala Thr Met Pro Asn 
        275                 280         


<210> 5194
<211> 203
<212> PRT
<213> Homo sapiens

<400> 5194
Met Ala Arg Pro Arg Pro Arg Glu Tyr Lys Ala Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu Leu 
            20                  25                  30          


Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr Pro Ile Phe Phe 
        35                  40                  45              


Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro 
    50                  55                  60                  


Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn Lys Arg Lys Gly 
65                  70                  75                  80  


Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Gly Val Lys Phe 
                85                  90                  95      


Thr Gly Tyr Gln Ala Ile Gln Gln Gln Ser Ser Ser Glu Thr Glu Gly 
            100                 105                 110         


Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu Glu Gly Asp Arg 
        115                 120                 125             


Val Glu Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu Lys Ala Gly Ser 
    130                 135                 140                 


Lys Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser Lys Gln Ser Arg 
145                 150                 155                 160 


Lys Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys Glu Glu Glu Asn 
                165                 170                 175     


Lys Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn Asp Thr Arg Asn Thr 
            180                 185                 190         


Thr Ser Asp Leu Gln Lys Thr Ser Glu Gly Thr 
        195                 200             


<210> 5195
<211> 179
<212> PRT
<213> Homo sapiens

<400> 5195
Met Lys Thr Pro Val Glu Leu Ala Val Ser Gly Met Gln Thr Leu Gly 
1               5                   10                  15      


Leu Gln His Arg Cys Arg Gly Gly Tyr Arg Val Lys Ala Arg Thr Ser 
            20                  25                  30          


Tyr Val Asp Glu Thr Leu Phe Gly Ser Pro Ala Gly Thr Arg Pro Thr 
        35                  40                  45              


Pro Pro Asp Phe Asp Pro Pro Trp Val Glu Lys Ala Asn Arg Thr Arg 
    50                  55                  60                  


Gly Val Gly Lys Glu Ala Ser Lys Ala Leu Gly Ala Lys Gly Ser Cys 
65                  70                  75                  80  


Glu Thr Thr Pro Ser Arg Gly Ser Thr Pro Thr Leu Thr Pro Arg Lys 
                85                  90                  95      


Lys Asn Lys Tyr Arg Pro Ile Ser His Thr Pro Ser Tyr Cys Asp Glu 
            100                 105                 110         


Ser Leu Phe Gly Ser Arg Ser Glu Gly Ala Ser Phe Gly Ala Pro Arg 
        115                 120                 125             


Met Ala Lys Gly Asp Ala Ala Lys Leu Arg Ala Leu Leu Trp Thr Pro 
    130                 135                 140                 


Pro Pro Thr Pro Arg Gly Ser His Ser Pro Arg Pro Arg Glu Ala Pro 
145                 150                 155                 160 


Pro Pro Val Pro Pro Thr Gln Met Gly Leu Arg Ile Ser Gly Leu Pro 
                165                 170                 175     


Arg Gln Gly 
            


<210> 5196
<211> 367
<212> PRT
<213> Homo sapiens

<400> 5196
Met Asp Gly Glu Asp Ile Pro Asp Phe Ser Ser Leu Lys Glu Glu Thr 
1               5                   10                  15      


Ala Tyr Trp Lys Glu Leu Ser Leu Lys Tyr Lys Gln Ser Phe Gln Glu 
            20                  25                  30          


Ala Arg Asp Glu Leu Val Glu Phe Gln Glu Gly Ser Arg Glu Leu Glu 
        35                  40                  45              


Ala Glu Leu Glu Ala Gln Leu Val Gln Ala Glu Gln Arg Asn Arg Asp 
    50                  55                  60                  


Leu Gln Ala Asp Asn Gln Arg Leu Lys Tyr Glu Val Glu Ala Leu Lys 
65                  70                  75                  80  


Glu Lys Leu Glu His Gln Tyr Ala Gln Ser Tyr Lys Gln Val Ser Val 
                85                  90                  95      


Leu Glu Asp Asp Leu Ser Gln Thr Arg Ala Ile Lys Glu Gln Leu His 
            100                 105                 110         


Lys Tyr Val Arg Glu Leu Glu Gln Ala Asn Asp Asp Leu Glu Arg Ala 
        115                 120                 125             


Lys Arg Ala Thr Ile Val Ser Leu Glu Asp Phe Glu Gln Arg Leu Asn 
    130                 135                 140                 


Gln Ala Ile Glu Arg Asn Ala Phe Leu Glu Ser Glu Leu Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Leu Leu Val Ser Val Gln Arg Leu Lys Asp Glu Ala Arg Asp 
                165                 170                 175     


Leu Arg Gln Glu Leu Ala Val Arg Glu Arg Gln Gln Glu Val Thr Arg 
            180                 185                 190         


Lys Ser Ala Pro Ser Ser Pro Thr Leu Asp Cys Glu Lys Met Asp Ser 
        195                 200                 205             


Ala Val Gln Ala Ser Leu Ser Leu Pro Ala Thr Pro Val Gly Lys Gly 
    210                 215                 220                 


Thr Glu Asn Thr Phe Pro Ser Pro Lys Ala Ile Pro Asn Gly Phe Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Thr Pro Ser Ala Arg Ile Ser Ala Leu Asn Ile Val 
                245                 250                 255     


Gly Asp Leu Leu Arg Lys Val Gly Ala Leu Glu Ser Lys Leu Ala Ala 
            260                 265                 270         


Cys Arg Asn Phe Ala Lys Asp Gln Ala Ser Arg Lys Ser Tyr Ile Ser 
        275                 280                 285             


Gly Asn Val Asn Cys Gly Val Leu Asn Gly Asn Gly Thr Lys Phe Ser 
    290                 295                 300                 


Arg Ser Gly His Thr Ser Phe Phe Asp Lys Gly Ser Ser Ser Ser Cys 
305                 310                 315                 320 


Ala Ile Arg Ala Ser Arg Arg Arg Phe Ser Ser Ser Ser Ala Asp Leu 
                325                 330                 335     


Ala Gly Arg Gly Gly Gly Asp Gly Ser Ile Pro Ala Gln His Ser Thr 
            340                 345                 350         


Gly Ala Ser Gly Lys Ala Pro Pro Pro Thr Leu Leu Leu Glu Thr 
        355                 360                 365         


<210> 5197
<211> 196
<212> PRT
<213> Homo sapiens

<400> 5197
Met Gly Ser Arg Ser Ser His Ala Ala Val Ile Pro Asp Gly Asp Ser 
1               5                   10                  15      


Ile Arg Arg Glu Thr Gly Phe Ser Gln Ala Ser Leu Leu Arg Leu His 
            20                  25                  30          


His Arg Phe Arg Ala Leu Asp Arg Asn Lys Lys Gly Tyr Leu Ser Arg 
        35                  40                  45              


Met Asp Leu Gln Gln Ile Gly Ala Leu Ala Val Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Glu Ser Phe Phe Pro Asp Gly Ser Gln Arg Val Asp Phe 
65                  70                  75                  80  


Pro Gly Phe Val Arg Val Leu Ala His Phe Arg Pro Val Glu Asp Glu 
                85                  90                  95      


Asp Thr Glu Thr Gln Asp Pro Lys Lys Pro Glu Pro Leu Asn Ser Arg 
            100                 105                 110         


Arg Asn Lys Leu His Tyr Ala Phe Gln Leu Tyr Asp Leu Asp Arg Asp 
        115                 120                 125             


Gly Lys Ile Ser Arg His Glu Met Leu Gln Val Leu Arg Leu Met Val 
    130                 135                 140                 


Gly Val Gln Val Thr Glu Glu Gln Leu Glu Asn Ile Ala Asp Arg Thr 
145                 150                 155                 160 


Val Gln Glu Ala Asp Glu Asp Gly Asp Gly Ala Val Ser Phe Val Glu 
                165                 170                 175     


Phe Thr Lys Ser Leu Glu Lys Met Asp Val Glu Gln Lys Met Ser Ile 
            180                 185                 190         


Arg Ile Leu Lys 
        195     


<210> 5198
<211> 770
<212> PRT
<213> Homo sapiens

<400> 5198
Met Phe Arg Tyr Glu Ser Leu Glu Asp Cys Pro Leu Asp Glu Asp Glu 
1               5                   10                  15      


Asp Ala Phe Gln Gly Leu Gly Glu Glu Asp Glu Glu Ile Asp Gln Phe 
            20                  25                  30          


Asn Asp Asp Thr Phe Gly Ser Gly Ala Val Asp Asp Asp Trp Gln Glu 
        35                  40                  45              


Ala His Glu Arg Leu Ala Glu Leu Glu Glu Lys Leu Pro Val Ala Val 
    50                  55                  60                  


Asn Glu Gln Thr Gly Asn Gly Glu Arg Asp Glu Met Asp Leu Leu Gly 
65                  70                  75                  80  


Asp His Glu Glu Asn Leu Ala Glu Arg Leu Ser Lys Met Val Ile Glu 
                85                  90                  95      


Asn Glu Leu Glu Asp Pro Ala Ile Met Arg Ala Val Gln Thr Arg Pro 
            100                 105                 110         


Val Leu Gln Pro Gln Pro Gly Ser Leu Asn Ser Ser Ile Trp Asp Gly 
        115                 120                 125             


Ser Glu Val Leu Arg Arg Ile Arg Gly Pro Leu Leu Ala Gln Glu Met 
    130                 135                 140                 


Pro Thr Val Ser Val Leu Glu Tyr Ala Leu Pro Gln Arg Pro Pro Gln 
145                 150                 155                 160 


Gly Pro Glu Asp Asp Arg Asp Leu Ser Glu Arg Ala Leu Pro Arg Arg 
                165                 170                 175     


Ser Thr Ser Pro Ile Ile Gly Ser Pro Pro Val Arg Ala Val Pro Ile 
            180                 185                 190         


Gly Thr Pro Pro Lys Gln Met Ala Val Pro Ser Phe Thr Gln Gln Ile 
        195                 200                 205             


Leu Cys Pro Lys Pro Val His Val Arg Pro Pro Met Pro Pro Arg Tyr 
    210                 215                 220                 


Pro Ala Pro Tyr Gly Glu Arg Met Ser Pro Asn Gln Leu Cys Ser Val 
225                 230                 235                 240 


Pro Asn Ser Ser Leu Leu Gly His Pro Phe Pro Pro Ser Val Pro Pro 
                245                 250                 255     


Val Leu Ser Pro Leu Gln Arg Ala Gln Leu Leu Gly Gly Ala Gln Leu 
            260                 265                 270         


Gln Pro Gly Arg Met Ser Pro Ser Gln Phe Ala Arg Val Pro Gly Phe 
        275                 280                 285             


Val Gly Ser Pro Leu Ala Ala Met Asn Pro Lys Leu Leu Gln Gly Arg 
    290                 295                 300                 


Val Gly Gln Met Leu Pro Pro Ala Pro Gly Phe Arg Ala Phe Phe Ser 
305                 310                 315                 320 


Ala Pro Pro Ser Ala Thr Pro Pro Pro Gln Gln His Pro Pro Gly Pro 
                325                 330                 335     


Gly Pro His Leu Gln Asn Leu Arg Ser Gln Ala Pro Met Phe Arg Pro 
            340                 345                 350         


Asp Thr Thr His Leu His Pro Gln His Arg Arg Leu Leu His Gln Arg 
        355                 360                 365             


Gln Gln Gln Asn Arg Ser Gln His Arg Asn Leu Asn Gly Ala Gly Asp 
    370                 375                 380                 


Arg Gly Ser His Arg Ser Ser His Gln Asp His Leu Arg Lys Asp Pro 
385                 390                 395                 400 


Tyr Ala Asn Leu Met Leu Gln Arg Glu Lys Asp Trp Val Ser Lys Ile 
                405                 410                 415     


Gln Met Met Gln Leu Gln Ser Thr Asp Pro Tyr Leu Asp Asp Phe Tyr 
            420                 425                 430         


Tyr Gln Asn Tyr Phe Glu Lys Leu Glu Lys Leu Ser Ala Ala Glu Glu 
        435                 440                 445             


Ile Gln Gly Asp Gly Pro Lys Lys Glu Arg Thr Lys Leu Ile Thr Pro 
    450                 455                 460                 


Gln Val Ala Lys Leu Glu His Ala Tyr Lys Pro Val Gln Phe Glu Gly 
465                 470                 475                 480 


Ser Leu Gly Lys Leu Thr Val Ser Ser Val Asn Asn Pro Arg Lys Met 
                485                 490                 495     


Ile Asp Ala Val Val Thr Ser Arg Ser Glu Asp Asp Glu Thr Lys Glu 
            500                 505                 510         


Lys Gln Val Arg Asp Lys Arg Arg Lys Thr Leu Val Ile Ile Glu Lys 
        515                 520                 525             


Thr Tyr Ser Leu Leu Leu Asp Val Glu Asp Tyr Glu Arg Arg Tyr Leu 
    530                 535                 540                 


Leu Ser Leu Glu Glu Glu Arg Pro Ala Leu Met Asp Asp Arg Lys His 
545                 550                 555                 560 


Lys Ile Cys Ser Met Tyr Asp Asn Leu Arg Gly Lys Leu Pro Gly Gln 
                565                 570                 575     


Glu Arg Pro Ser Asp Asp His Phe Val Gln Ile Met Cys Ile Arg Lys 
            580                 585                 590         


Gly Lys Arg Met Val Ala Arg Ile Leu Pro Phe Leu Ser Thr Glu Gln 
        595                 600                 605             


Ala Ala Asp Ile Leu Met Thr Thr Ala Arg Asn Leu Pro Phe Leu Ile 
    610                 615                 620                 


Lys Lys Asp Ala Gln Asp Glu Val Leu Pro Cys Leu Leu Ser Pro Phe 
625                 630                 635                 640 


Ser Leu Leu Leu Tyr His Leu Pro Ser Val Ser Ile Thr Ser Leu Leu 
                645                 650                 655     


Arg Gln Leu Met Asn Leu Pro Gln Ser Ala Ala Thr Pro Ala Leu Ser 
            660                 665                 670         


Asn Pro His Leu Thr Ala Val Leu Gln Asn Lys Phe Gly Leu Ser Leu 
        675                 680                 685             


Leu Leu Ile Leu Leu Ser Arg Gly Glu Asp Leu Gln Ser Ser Asp Pro 
    690                 695                 700                 


Ala Thr Glu Ser Thr Gln Asn Asn Gln Trp Thr Glu Val Met Phe Met 
705                 710                 715                 720 


Ala Thr Arg Glu Leu Leu Arg Ile Pro Gln Ala Ala Leu Ala Lys Pro 
                725                 730                 735     


Ile Ser Ile Pro Thr Asn Leu Val Ser Leu Phe Ser Arg Tyr Val Asp 
            740                 745                 750         


Arg Gln Lys Leu Asn Leu Leu Glu Thr Lys Leu Gln Leu Val Gln Gly 
        755                 760                 765             


Ile Arg 
    770 


<210> 5199
<211> 505
<212> PRT
<213> Homo sapiens

<400> 5199
Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210> 5200
<211> 227
<212> PRT
<213> Homo sapiens

<400> 5200
Met Ser Val Val Pro Pro Asn Arg Ser Gln Thr Gly Trp Pro Arg Gly 
1               5                   10                  15      


Val Thr Gln Phe Gly Asn Lys Tyr Ile Gln Gln Thr Lys Pro Leu Thr 
            20                  25                  30          


Leu Glu Arg Thr Ile Asn Leu Tyr Pro Leu Thr Asn Tyr Thr Phe Gly 
        35                  40                  45              


Thr Lys Glu Pro Leu Tyr Glu Lys Asp Ser Ser Val Ala Ala Arg Phe 
    50                  55                  60                  


Gln Arg Met Arg Glu Glu Phe Asp Lys Ile Gly Met Arg Arg Thr Val 
65                  70                  75                  80  


Glu Gly Val Leu Ile Val His Glu His Arg Leu Pro His Val Leu Leu 
                85                  90                  95      


Leu Gln Leu Gly Thr Thr Phe Phe Lys Leu Pro Gly Gly Glu Leu Asn 
            100                 105                 110         


Pro Gly Glu Asp Glu Val Glu Gly Leu Lys Arg Leu Met Thr Glu Ile 
        115                 120                 125             


Leu Gly Arg Gln Asp Gly Val Leu Gln Asp Trp Val Ile Asp Asp Cys 
    130                 135                 140                 


Ile Gly Asn Trp Trp Arg Pro Asn Phe Glu Pro Pro Gln Tyr Pro Tyr 
145                 150                 155                 160 


Ile Pro Ala His Ile Thr Lys Pro Lys Glu His Lys Lys Leu Phe Leu 
                165                 170                 175     


Val Gln Leu Gln Glu Lys Ala Leu Phe Ala Val Pro Lys Asn Tyr Lys 
            180                 185                 190         


Leu Val Ala Ala Pro Leu Phe Glu Leu Tyr Asp Asn Ala Pro Gly Tyr 
        195                 200                 205             


Gly Pro Ile Ile Ser Ser Leu Pro Gln Leu Leu Ser Arg Phe Asn Phe 
    210                 215                 220                 


Ile Tyr Asn 
225         


<210> 5201
<211> 747
<212> PRT
<213> Homo sapiens

<400> 5201
Met Ser Gln Val Lys Ser Ser Tyr Ser Tyr Asp Ala Pro Ser Asp Phe 
1               5                   10                  15      


Ile Asn Phe Ser Ser Leu Asp Asp Glu Gly Asp Thr Gln Asn Ile Asp 
            20                  25                  30          


Ser Trp Phe Glu Glu Lys Ala Asn Leu Glu Asn Lys Leu Leu Gly Lys 
        35                  40                  45              


Asn Gly Thr Gly Gly Leu Phe Gln Gly Lys Thr Pro Leu Arg Lys Ala 
    50                  55                  60                  


Asn Leu Gln Gln Ala Ile Val Thr Pro Leu Lys Pro Val Asp Asn Thr 
65                  70                  75                  80  


Tyr Tyr Lys Glu Ala Glu Lys Glu Asn Leu Val Glu Gln Ser Ile Pro 
                85                  90                  95      


Ser Asn Ala Cys Ser Ser Leu Glu Val Glu Ala Ala Ile Ser Arg Lys 
            100                 105                 110         


Thr Pro Ala Gln Pro Gln Arg Arg Ser Leu Arg Leu Ser Ala Gln Lys 
        115                 120                 125             


Asp Leu Glu Gln Lys Glu Lys His His Val Lys Met Lys Ala Lys Arg 
    130                 135                 140                 


Cys Ala Thr Pro Val Ile Ile Asp Glu Ile Leu Pro Ser Lys Lys Met 
145                 150                 155                 160 


Lys Val Ser Asn Asn Lys Lys Lys Pro Glu Glu Glu Gly Ser Ala His 
                165                 170                 175     


Gln Asp Thr Ala Glu Lys Asn Ala Ser Ser Pro Glu Lys Ala Lys Gly 
            180                 185                 190         


Arg His Thr Val Pro Cys Met Pro Pro Ala Lys Gln Lys Phe Leu Lys 
        195                 200                 205             


Ser Thr Glu Glu Gln Glu Leu Glu Lys Ser Met Lys Met Gln Gln Glu 
    210                 215                 220                 


Val Val Glu Met Arg Lys Lys Asn Glu Glu Phe Lys Lys Leu Ala Leu 
225                 230                 235                 240 


Ala Gly Ile Gly Gln Pro Val Lys Lys Ser Val Ser Gln Val Thr Lys 
                245                 250                 255     


Ser Val Asp Phe His Phe Arg Thr Asp Glu Arg Ile Lys Gln His Pro 
            260                 265                 270         


Lys Asn Gln Glu Glu Tyr Lys Glu Val Asn Phe Thr Ser Glu Leu Arg 
        275                 280                 285             


Lys His Pro Ser Ser Pro Ala Arg Val Thr Lys Gly Cys Thr Ile Val 
    290                 295                 300                 


Lys Pro Phe Asn Leu Ser Gln Gly Lys Lys Arg Thr Phe Asp Glu Thr 
305                 310                 315                 320 


Val Ser Thr Tyr Val Pro Leu Ala Gln Gln Val Glu Asp Phe His Lys 
                325                 330                 335     


Arg Thr Pro Asn Arg Tyr His Leu Arg Ser Lys Lys Asp Asp Ile Asn 
            340                 345                 350         


Leu Leu Pro Ser Lys Ser Ser Val Thr Lys Ile Cys Arg Asp Pro Gln 
        355                 360                 365             


Thr Pro Val Leu Gln Thr Lys His Arg Ala Arg Ala Val Thr Cys Lys 
    370                 375                 380                 


Ser Thr Ala Glu Leu Glu Ala Glu Glu Leu Glu Lys Leu Gln Gln Tyr 
385                 390                 395                 400 


Lys Phe Lys Ala Arg Glu Leu Asp Pro Arg Ile Leu Glu Gly Gly Pro 
                405                 410                 415     


Ile Leu Pro Lys Lys Pro Pro Val Lys Pro Pro Thr Glu Pro Ile Gly 
            420                 425                 430         


Phe Asp Leu Glu Ile Glu Lys Arg Ile Gln Glu Arg Glu Ser Lys Lys 
        435                 440                 445             


Lys Thr Glu Asp Glu His Phe Glu Phe His Ser Arg Pro Cys Pro Thr 
    450                 455                 460                 


Lys Ile Leu Glu Asp Val Val Gly Val Pro Glu Lys Lys Val Leu Pro 
465                 470                 475                 480 


Ile Thr Val Pro Lys Ser Pro Ala Phe Ala Leu Lys Asn Arg Ile Arg 
                485                 490                 495     


Met Pro Thr Lys Glu Asp Glu Glu Glu Asp Glu Pro Val Val Ile Lys 
            500                 505                 510         


Ala Gln Pro Val Pro His Tyr Gly Val Pro Phe Lys Pro Gln Ile Pro 
        515                 520                 525             


Glu Ala Arg Thr Val Glu Ile Cys Pro Phe Ser Phe Asp Ser Arg Asp 
    530                 535                 540                 


Lys Glu Arg Gln Leu Gln Lys Glu Lys Lys Ile Lys Glu Leu Gln Lys 
545                 550                 555                 560 


Gly Glu Val Pro Lys Phe Lys Ala Leu Pro Leu Pro His Phe Asp Thr 
                565                 570                 575     


Ile Asn Leu Pro Glu Lys Lys Val Lys Asn Val Thr Gln Ile Glu Pro 
            580                 585                 590         


Phe Cys Leu Glu Thr Asp Arg Arg Gly Ala Leu Lys Ala Gln Thr Trp 
        595                 600                 605             


Lys His Gln Leu Glu Glu Glu Leu Arg Gln Gln Lys Glu Ala Ala Cys 
    610                 615                 620                 


Phe Lys Ala Arg Pro Asn Thr Val Ile Ser Gln Glu Pro Phe Val Pro 
625                 630                 635                 640 


Lys Lys Glu Lys Lys Ser Val Ala Glu Gly Leu Ser Gly Ser Leu Val 
                645                 650                 655     


Gln Glu Pro Phe Gln Leu Ala Thr Glu Lys Arg Ala Lys Glu Arg Gln 
            660                 665                 670         


Glu Leu Glu Lys Arg Met Ala Glu Val Glu Ala Gln Lys Ala Gln Gln 
        675                 680                 685             


Leu Glu Glu Ala Arg Leu Gln Glu Glu Glu Gln Lys Lys Glu Glu Leu 
    690                 695                 700                 


Ala Arg Leu Arg Arg Glu Leu Val His Lys Ala Asn Pro Ile Arg Lys 
705                 710                 715                 720 


Tyr Gln Gly Leu Glu Ile Lys Ser Ser Asp Gln Pro Leu Thr Val Pro 
                725                 730                 735     


Val Ser Pro Lys Phe Ser Thr Arg Phe His Cys 
            740                 745         


<210> 5202
<211> 119
<212> PRT
<213> Homo sapiens

<400> 5202
Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr 
1               5                   10                  15      


Ile Glu Leu Lys Asn Gly Thr Gln Val His Gly Thr Ile Thr Gly Val 
            20                  25                  30          


Asp Val Ser Met Asn Thr His Leu Lys Ala Val Lys Met Thr Leu Lys 
        35                  40                  45              


Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser Ile Arg Gly Asn Asn 
    50                  55                  60                  


Ile Arg Tyr Phe Ile Leu Pro Asp Ser Leu Pro Leu Asp Thr Leu Leu 
65                  70                  75                  80  


Val Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala 
                85                  90                  95      


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Arg Gly Gly Pro Arg Arg 
        115                 


<210> 5203
<211> 184
<212> PRT
<213> Homo sapiens

<400> 5203
Met Met Gly Ala Ser Thr Leu Gln Glu Pro Ala Leu Ser Pro Gly Arg 
1               5                   10                  15      


Cys Pro Arg Gln Pro Leu Arg Ser Lys Phe Gly His Gln Gly Ser Thr 
            20                  25                  30          


Val Gln Arg Lys Cys Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys 
        35                  40                  45              


Met Ile Glu Met Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His 
    50                  55                  60                  


Glu Phe Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly 
65                  70                  75                  80  


Leu Thr Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu 
                85                  90                  95      


Thr Ala Ser Cys Ser Thr Phe Asn Ile Ser Gly Ala Ser Pro Ala Arg 
            100                 105                 110         


Gln Gln Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro 
        115                 120                 125             


Pro Pro Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys 
    130                 135                 140                 


Gln Pro Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys 
145                 150                 155                 160 


Pro Tyr Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu 
                165                 170                 175     


Lys Glu Glu Glu Met Ser Trp Lys 
            180                 


<210> 5204
<211> 400
<212> PRT
<213> Homo sapiens

<400> 5204
Met Ala Ser Glu Lys Pro Leu Ala Ala Val Thr Cys Thr Ala Pro Val 
1               5                   10                  15      


Asn Ile Ala Val Ile Lys Tyr Trp Gly Lys Arg Asp Glu Glu Leu Val 
            20                  25                  30          


Leu Pro Ile Asn Ser Ser Leu Ser Val Thr Leu His Gln Asp Gln Leu 
        35                  40                  45              


Lys Thr Thr Thr Thr Ala Val Ile Ser Lys Asp Phe Thr Glu Asp Arg 
    50                  55                  60                  


Ile Trp Leu Asn Gly Arg Glu Glu Asp Val Gly Gln Pro Arg Leu Gln 
65                  70                  75                  80  


Ala Cys Leu Arg Glu Ile Arg Cys Leu Ala Arg Lys Arg Arg Asn Ser 
                85                  90                  95      


Arg Asp Gly Asp Pro Leu Pro Ser Ser Leu Ser Cys Lys Val His Val 
            100                 105                 110         


Ala Ser Val Asn Asn Phe Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala 
        115                 120                 125             


Ala Gly Tyr Ala Cys Leu Ala Tyr Thr Leu Ala Arg Val Tyr Gly Val 
    130                 135                 140                 


Glu Ser Asp Leu Ser Glu Val Ala Arg Arg Gly Ser Gly Ser Ala Cys 
145                 150                 155                 160 


Arg Ser Leu Tyr Gly Gly Phe Val Glu Trp Gln Met Gly Glu Gln Ala 
                165                 170                 175     


Asp Gly Lys Asp Ser Ile Ala Arg Gln Val Ala Pro Glu Ser His Trp 
            180                 185                 190         


Pro Glu Leu Arg Val Leu Ile Leu Val Val Ser Ala Glu Lys Lys Leu 
        195                 200                 205             


Thr Gly Ser Thr Val Gly Met Arg Ala Ser Val Glu Thr Ser Pro Leu 
    210                 215                 220                 


Leu Arg Phe Arg Ala Glu Ser Val Val Pro Ala Arg Met Ala Glu Met 
225                 230                 235                 240 


Ala Arg Cys Ile Arg Glu Arg Asp Phe Pro Ser Phe Ala Gln Leu Thr 
                245                 250                 255     


Met Lys Asp Ser Asn Gln Phe His Ala Thr Cys Leu Asp Thr Phe Pro 
            260                 265                 270         


Pro Ile Ser Tyr Leu Asn Ala Ile Ser Trp Arg Ile Ile His Leu Val 
        275                 280                 285             


His Arg Phe Asn Ala His His Gly Asp Thr Lys Val Ala Tyr Thr Phe 
    290                 295                 300                 


Asp Ala Gly Pro Asn Ala Val Ile Phe Thr Leu Asp Asp Thr Val Ala 
305                 310                 315                 320 


Glu Phe Val Ala Ala Val Trp His Gly Phe Pro Pro Gly Ser Asn Gly 
                325                 330                 335     


Asp Thr Phe Leu Lys Gly Leu Gln Val Arg Pro Ala Pro Leu Ser Ala 
            340                 345                 350         


Glu Leu Gln Ala Ala Leu Ala Met Glu Pro Thr Pro Gly Gly Val Lys 
        355                 360                 365             


Tyr Ile Ile Val Thr Gln Val Gly Pro Gly Pro Gln Ile Leu Asp Asp 
    370                 375                 380                 


Pro Cys Ala His Leu Leu Gly Pro Asp Gly Leu Pro Lys Pro Ala Ala 
385                 390                 395                 400 


<210> 5205
<211> 449
<212> PRT
<213> Homo sapiens

<400> 5205
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Val 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Ala Asp Ser Ala Asp Gly Glu Asp Glu Gly Glu Glu 
        435                 440                 445             


Tyr 
    


<210> 5206
<211> 454
<212> PRT
<213> Homo sapiens

<400> 5206
Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
            20                  25                  30          


Lys Gly Thr Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
    50                  55                  60                  


Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
65                  70                  75                  80  


Asp Ile Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         


Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
        115                 120                 125             


Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile 
145                 150                 155                 160 


Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
    210                 215                 220                 


Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
            260                 265                 270         


Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser 
        275                 280                 285             


Gly Arg Lys Pro Glu Arg Arg Arg Leu Lys Thr Thr Arg Leu Lys Glu 
    290                 295                 300                 


Tyr Thr Ile Lys Ser His Ser Ser Leu Pro Pro Asn Asn Ser Tyr Ala 
305                 310                 315                 320 


Asp Phe Glu Arg Phe Ser Lys Val Leu Glu Glu Ala Ala Ala Ala Glu 
                325                 330                 335     


Glu Gly Leu Arg Glu Leu Gln Arg Ser Arg Arg Leu Cys His Glu Asp 
            340                 345                 350         


Val Glu Ala Leu Ala Ala Ile Tyr Glu Glu Lys Glu Ala Trp Tyr Arg 
        355                 360                 365             


Glu Glu Ser Asp Ser Leu Gly Gln Asp Leu Arg Arg Leu Arg Gln Glu 
    370                 375                 380                 


Leu Leu Lys Thr Glu Ala Leu Lys Arg Gln Ala Gln Glu Glu Ala Lys 
385                 390                 395                 400 


Gly Ala Leu Leu Gly Thr Ser Gly Leu Lys Arg Arg Phe Ser Arg Leu 
                405                 410                 415     


Glu Asn Arg Tyr Glu Ala Leu Ala Lys Gln Val Ala Ser Glu Met Arg 
            420                 425                 430         


Phe Val Gln Asp Leu Val Arg Ala Leu Glu Gln Glu Lys Leu Gln Gly 
        435                 440                 445             


Val Glu Cys Gly Leu Arg 
    450                 


<210> 5207
<211> 441
<212> PRT
<213> Homo sapiens

<400> 5207
Met Lys Lys Phe Phe Gln Glu Phe Lys Ala Asp Ile Lys Phe Lys Ser 
1               5                   10                  15      


Ala Gly Pro Gly Gln Lys Leu Lys Glu Ser Val Gly Glu Lys Ala His 
            20                  25                  30          


Lys Glu Lys Pro Asn Gln Pro Ala Pro Arg Pro Pro Arg Gln Gly Pro 
        35                  40                  45              


Thr Asn Glu Ala Gln Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu 
    50                  55                  60                  


Gln Lys Gln Ser Arg Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg 
65                  70                  75                  80  


Asn Gln Val Arg Lys Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser 
                85                  90                  95      


Pro Glu Ala Pro Gly Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly 
            100                 105                 110         


Ser Ala His Leu Ala Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr 
        115                 120                 125             


Gly Ala Thr Leu Arg Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala 
    130                 135                 140                 


Ile Leu Leu His Phe Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys 
145                 150                 155                 160 


Ile Tyr Thr Phe Asn Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp 
                165                 170                 175     


Thr Ile Ala Lys Tyr Leu Asp Asn Ile His Leu His Pro Glu Glu Glu 
            180                 185                 190         


Lys Tyr Arg Lys Ile Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile 
        195                 200                 205             


Asn Cys Leu Glu Gly Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln 
    210                 215                 220                 


Lys Val Leu Leu Pro Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr 
225                 230                 235                 240 


Val Leu Ser Glu Thr Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His 
                245                 250                 255     


Lys Glu Gln Leu Leu Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg 
            260                 265                 270         


Gln Arg Arg Val Phe Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu 
        275                 280                 285             


Pro Gly Asp Phe Phe Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln 
    290                 295                 300                 


Arg Leu Arg Ser Glu Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys 
305                 310                 315                 320 


Ala Met Arg Glu Lys Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr 
                325                 330                 335     


Thr Leu Leu Arg Val Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr 
            340                 345                 350         


Phe Tyr Ala Arg Glu Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu 
        355                 360                 365             


Ala Leu Gln Ser Asp Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly 
    370                 375                 380                 


Gln Lys Leu Ser Glu Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu 
385                 390                 395                 400 


Val Pro Ser Ala Leu Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu 
                405                 410                 415     


Asp Ile Lys Ala Ala Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu 
            420                 425                 430         


Leu Leu Ser Ala Ile Glu Lys Leu Leu 
        435                 440     


<210> 5208
<211> 299
<212> PRT
<213> Homo sapiens

<400> 5208
Met Arg Asp Leu Leu Leu His Trp Gly Pro Gly Pro Pro Ile Arg Ala 
1               5                   10                  15      


Pro Gln Glu Glu Ala Glu Ala Leu Leu Glu Leu Gln Gly Arg Leu Gln 
            20                  25                  30          


Glu Ala Gln Asp Thr Thr Glu Ala Leu Arg Ala Gln Leu Gly Val Gln 
        35                  40                  45              


Glu Val Gln Leu Gln Gly Leu Gln Gly Ala Leu Gln Gln Leu Gln Gln 
    50                  55                  60                  


Glu Thr Glu Gln Asn Cys Arg Arg Glu Leu Gln Gln Met His Gly Gln 
65                  70                  75                  80  


Leu Ala Gly Leu Arg Ala Arg Met Ala Ser Leu Arg Gln Gly Cys Gly 
                85                  90                  95      


Asp Leu Arg Gly Leu Val Ser Thr Phe Thr Gln Ser Cys Gln Gly Ser 
            100                 105                 110         


Leu Ser Glu Ala Arg Gly Gln Val Ser Trp Ala Leu Gly Ala Leu Ser 
        115                 120                 125             


Ser Gly Gly Pro Gly Thr Gln Leu Pro Glu Gly Gln Gln Gly Pro Pro 
    130                 135                 140                 


Ala Gly Cys Pro Gly Arg Leu Pro Glu Leu Lys Gly Asn Ile Arg Val 
145                 150                 155                 160 


Leu Cys Arg Leu Arg Pro Gly Thr Ser Ser Ser Leu Val Ser Val Glu 
                165                 170                 175     


Pro Gly Pro Gly Gly Thr Val Thr Thr Cys Tyr Arg Gly Arg His Arg 
            180                 185                 190         


Arg Phe Arg Leu Asp Trp Val Phe Pro Pro Asp Ala Ser Gln Glu Glu 
        195                 200                 205             


Val Phe Arg Glu Leu Glu Pro Ala Val Leu Ser Cys Leu Arg Gly Tyr 
    210                 215                 220                 


Ser Val Cys Ile Phe Thr Tyr Gly Gln Thr Gly Thr Gly Lys Thr Tyr 
225                 230                 235                 240 


Ser Met Glu Gly Pro Pro Glu Asp Pro Gly Ile Val Pro Arg Ala Leu 
                245                 250                 255     


Gln Ser Leu Phe Arg Glu Met Gly Ala Gly Arg Gln His Arg Arg Tyr 
            260                 265                 270         


His Gly Arg Cys Leu Ser Pro Ala Glu Ser Pro Glu His Pro Arg Pro 
        275                 280                 285             


Gly Leu Pro Pro Cys Arg Ala Arg Ser Pro Leu 
    290                 295                 


<210> 5209
<211> 838
<212> PRT
<213> Homo sapiens

<400> 5209
Met Tyr Ala Phe Tyr Ser Leu Leu Ile Tyr Ile Phe Tyr Ser Leu Phe 
1               5                   10                  15      


Arg Arg Asp Gly Gly Ala Ala Ala Ala Ala Glu Pro Gly Asp Pro Ala 
            20                  25                  30          


Gln Arg Ala Arg Lys Pro Arg Gly Arg Arg Arg Pro Asp Leu Pro Ala 
        35                  40                  45              


Pro Glu Leu Trp Thr Glu Leu Thr Gly Leu Ala Ala Ser Ser Glu Pro 
    50                  55                  60                  


Glu Asp Gly Ser Glu Gly Ala Ala Glu Gly Arg Ala Ala Ala Val Ser 
65                  70                  75                  80  


Leu Glu Glu Ala Leu Leu Arg Leu Ala Glu Phe Leu Ser Val Gln Leu 
                85                  90                  95      


Gly Ala Glu Glu Ser Cys Gly Gly Pro Ala Asp Leu Gly Gln Ser Gly 
            100                 105                 110         


Glu Val Pro Ser Leu Leu Thr Val Thr Ser Gln Leu Leu Ala Leu Leu 
        115                 120                 125             


Ala Trp Leu Arg Ser Pro Arg Gly Arg Gln Ala Leu Leu Gln Gly Thr 
    130                 135                 140                 


Gln Pro Ala Pro Arg Val Arg Pro Pro Ser Pro Asp Gly Ser Thr Ser 
145                 150                 155                 160 


Gln Glu Glu Ser Pro Ser His Phe Thr Ala Val Pro Gly Glu Pro Leu 
                165                 170                 175     


Gly Asp Glu Thr Gln Gly Gln Gln Pro Leu Gln Leu Glu Glu Asp Gln 
            180                 185                 190         


Arg Ala Trp Gln Arg Leu Glu Gln Leu Ile Leu Gly Gln Leu Glu Glu 
        195                 200                 205             


Leu Lys Gln Gln Leu Glu Gln Gln Glu Glu Glu Leu Gly Arg Leu Arg 
    210                 215                 220                 


Leu Gly Val Gly Ala Thr Asp Ser Glu Lys Arg Val Gln His Leu Thr 
225                 230                 235                 240 


Leu Glu Asn Glu Ala Leu Lys Gln Ser Leu Ser Leu Met Arg Asp Leu 
                245                 250                 255     


Leu Leu His Trp Gly Pro Gly Pro Pro Ile Arg Ala Pro Gln Glu Glu 
            260                 265                 270         


Ala Glu Ala Leu Leu Glu Leu Gln Gly Arg Leu Gln Glu Ala Gln Asp 
        275                 280                 285             


Thr Thr Glu Ala Leu Arg Ala Gln Leu Gly Val Gln Glu Val Gln Leu 
    290                 295                 300                 


Gln Gly Leu Gln Gly Ala Leu Gln Gln Leu Gln Gln Glu Thr Glu Gln 
305                 310                 315                 320 


Asn Cys Arg Arg Glu Leu Gln Gln Met His Gly Gln Leu Ala Gly Leu 
                325                 330                 335     


Arg Ala Arg Met Ala Ser Leu Arg Gln Gly Cys Gly Asp Leu Arg Gly 
            340                 345                 350         


Leu Val Ser Thr Phe Thr Gln Ser Cys Gln Gly Ser Leu Ser Glu Ala 
        355                 360                 365             


Arg Gly Gln Val Ser Trp Ala Leu Gly Ala Leu Ser Ser Gly Gly Pro 
    370                 375                 380                 


Gly Thr Gln Leu Pro Glu Gly Gln Gln Gly Pro Pro Ala Gly Cys Pro 
385                 390                 395                 400 


Gly Arg Leu Pro Glu Leu Lys Gly Asn Ile Arg Val Leu Cys Arg Leu 
                405                 410                 415     


Arg Pro Gly Thr Ser Ser Ser Leu Val Ser Val Glu Pro Gly Pro Gly 
            420                 425                 430         


Gly Thr Val Thr Thr Cys Tyr Arg Gly Arg His Arg Arg Phe Arg Leu 
        435                 440                 445             


Asp Trp Val Phe Pro Pro Asp Ala Ser Gln Glu Glu Val Phe Arg Glu 
    450                 455                 460                 


Leu Glu Pro Ala Val Leu Ser Cys Leu Arg Gly Tyr Ser Val Cys Ile 
465                 470                 475                 480 


Phe Thr Tyr Gly Gln Thr Gly Thr Gly Lys Thr Tyr Ser Met Glu Gly 
                485                 490                 495     


Pro Pro Glu Asp Pro Gly Ile Val Pro Arg Ala Leu Gln Ser Leu Phe 
            500                 505                 510         


Arg Glu Met Gly Ala Gly Arg Gln His Arg Val Thr Leu Ser Met Val 
        515                 520                 525             


Glu Ile Tyr Asn Glu Ala Val Arg Asp Leu Leu Ala Pro Gly Pro Pro 
    530                 535                 540                 


Glu Arg Leu Ala Val Arg Gln Gly Pro Glu Gly Gln Gly Gly Ile Gln 
545                 550                 555                 560 


Val Ala Gly Leu Thr His Trp Asp Val Pro Asn Leu Glu Thr Leu His 
                565                 570                 575     


Gln Met Leu Lys Leu Gly Arg Ser Asn Arg Ala Thr Ala Ala Thr Ala 
            580                 585                 590         


Met Asn Gln Arg Ser Ser Arg Ser His Ala Leu Val Thr Leu Thr Leu 
        595                 600                 605             


Arg Ala Ala Ser Pro Pro Arg Ala Pro Gly Thr Ala Gly Thr Leu His 
    610                 615                 620                 


Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Arg Lys Ala Gly Ala Ala 
625                 630                 635                 640 


Gly Pro Pro Arg Gly Asp Pro Asp Gly Ala Arg Arg Leu Arg Glu Ala 
                645                 650                 655     


Gln Thr Ile Asn Arg Ser Leu Leu Ala Leu Gly Gly Val Met Ala Ala 
            660                 665                 670         


Leu Arg Ala His Arg Pro His Val Pro Phe Arg Asp Ser Gln Leu Thr 
        675                 680                 685             


Arg Leu Leu Gln Pro Ala Leu Gly Pro Gly Thr Thr Ala Val Leu Leu 
    690                 695                 700                 


Leu Gln Val Gly Ala Gly Ala Gly Gln Val Cys Ala Cys Arg Ser Pro 
705                 710                 715                 720 


Pro Thr Arg Ala Arg Pro Pro Ala Pro Leu Ala Arg Arg Ser Pro Arg 
                725                 730                 735     


Gly Arg Arg Ile Ser Gly Arg Gln Ser Ala Pro Ser Ser Ser Pro Thr 
            740                 745                 750         


Glu Trp Val Lys Trp Ser Trp Gly Gln Pro Gly Ala Ala Gly Ser Arg 
        755                 760                 765             


Ala Pro Pro Gly Arg Leu Leu Pro Ser Ala Pro Thr Leu Arg Ser Pro 
    770                 775                 780                 


Gly Pro Pro Ala Pro Leu Arg Arg Pro Leu Ala Val Leu His Ala Pro 
785                 790                 795                 800 


Val Pro Thr Thr Ala Arg Ala Arg Leu Ser Arg Pro Gln Arg Ala Cys 
                805                 810                 815     


Pro Ser Ser Pro Gly Ser Arg Pro Cys Pro Trp Gly Leu Arg Pro Gly 
            820                 825                 830         


Leu Cys Trp Gln Arg Arg 
        835             


<210> 5210
<211> 198
<212> PRT
<213> Homo sapiens

<400> 5210
Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          


Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              


Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  


Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  


Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu 
                85                  90                  95      


Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser 
            100                 105                 110         


Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly 
        115                 120                 125             


Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn 
    130                 135                 140                 


Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln 
145                 150                 155                 160 


Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp 
                165                 170                 175     


Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu 
            180                 185                 190         


Tyr Phe Ser Lys His Asn 
        195             


<210> 5211
<211> 459
<212> PRT
<213> Homo sapiens

<400> 5211
Met Ser Val Arg Phe Ser Ser Thr Ser Arg Arg Leu Gly Ser Cys Gly 
1               5                   10                  15      


Gly Thr Gly Ser Val Arg Leu Ser Ser Gly Gly Ala Gly Phe Gly Ala 
            20                  25                  30          


Gly Asn Thr Cys Gly Val Pro Gly Ile Gly Ser Gly Phe Ser Cys Ala 
        35                  40                  45              


Phe Gly Gly Ser Ser Ser Ala Gly Gly Tyr Gly Gly Gly Leu Gly Gly 
    50                  55                  60                  


Gly Ser Ala Ser Cys Ala Ala Phe Thr Gly Asn Glu His Gly Leu Leu 
65                  70                  75                  80  


Ser Gly Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala 
                85                  90                  95      


Ser Tyr Leu Glu Asn Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu 
            100                 105                 110         


Glu Gln Lys Ile Lys Gly Trp Tyr Glu Lys Phe Gly Pro Gly Ser Cys 
        115                 120                 125             


Arg Gly Leu Asp His Asp Tyr Ser Arg Tyr Phe Pro Ile Ile Asp Glu 
    130                 135                 140                 


Leu Lys Asn Gln Ile Ile Ser Ala Thr Thr Ser Asn Ala His Val Val 
145                 150                 155                 160 


Leu Gln Asn Asp Asn Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys 
                165                 170                 175     


Phe Glu Asn Glu Leu Ala Leu His Gln Ser Val Glu Ala Asp Ile Asn 
            180                 185                 190         


Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Cys Arg Thr Asp Leu 
        195                 200                 205             


Glu Ile Gln Leu Glu Thr Leu Ser Glu Glu Leu Ala Tyr Leu Lys Lys 
    210                 215                 220                 


Asn His Glu Glu Glu Met Lys Ala Leu Gln Cys Ala Ala Gly Gly Asn 
225                 230                 235                 240 


Val Asn Val Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Val Leu 
                245                 250                 255     


Leu Asn Asn Met Arg Ala Glu Tyr Glu Ala Leu Ala Glu Gln Asn Arg 
            260                 265                 270         


Arg Asp Ala Glu Ala Trp Phe Asn Glu Lys Ser Ala Ser Leu Gln Gln 
        275                 280                 285             


Gln Ile Ser Asp Asp Ala Gly Ala Thr Thr Ser Ala Arg Asn Glu Leu 
    290                 295                 300                 


Ile Glu Met Lys Arg Thr Leu Gln Thr Leu Glu Ile Glu Leu Gln Ser 
305                 310                 315                 320 


Leu Leu Ala Thr Lys His Ser Leu Glu Cys Ser Leu Thr Glu Thr Glu 
                325                 330                 335     


Ser Asn Tyr Cys Ala Gln Leu Ala Gln Ile Gln Ala Gln Ile Gly Ala 
            340                 345                 350         


Leu Glu Glu Gln Leu His Gln Val Arg Thr Glu Thr Glu Gly Gln Lys 
        355                 360                 365             


Leu Glu Tyr Glu Gln Leu Leu Asp Ile Lys Val His Leu Glu Lys Glu 
    370                 375                 380                 


Ile Glu Thr Tyr Cys Leu Leu Ile Asp Gly Glu Asp Gly Ser Cys Ser 
385                 390                 395                 400 


Lys Ser Lys Gly Tyr Gly Gly Pro Gly Asn Gln Thr Lys Asp Ser Ser 
                405                 410                 415     


Lys Thr Thr Ile Val Lys Thr Val Val Glu Glu Ile Asp Pro Arg Gly 
            420                 425                 430         


Lys Val Leu Ser Ser Arg Val His Thr Val Glu Glu Lys Ser Thr Lys 
        435                 440                 445             


Val Asn Asn Lys Asn Glu Gln Arg Val Ser Ser 
    450                 455                 


<210> 5212
<211> 277
<212> PRT
<213> Homo sapiens

<400> 5212
Met Pro Ser Val Ser Lys Ala Ala Ala Ala Ala Leu Ser Gly Ser Pro 
1               5                   10                  15      


Pro Gln Thr Glu Lys Pro Thr His Tyr Arg Tyr Leu Lys Glu Phe Arg 
            20                  25                  30          


Thr Glu Gln Cys Pro Leu Phe Ser Gln His Lys Cys Ala Gln His Arg 
        35                  40                  45              


Pro Phe Thr Cys Phe His Trp His Phe Leu Asn Gln Arg Arg Arg Arg 
    50                  55                  60                  


Pro Leu Arg Arg Arg Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val Tyr 
65                  70                  75                  80  


Cys Ser Lys Tyr Asn Glu Ala Thr Gly Val Cys Pro Asp Gly Asp Glu 
                85                  90                  95      


Cys Pro Tyr Leu His Arg Thr Thr Gly Asp Thr Glu Arg Lys Tyr His 
            100                 105                 110         


Leu Arg Tyr Tyr Lys Thr Gly Thr Cys Ile His Glu Thr Asp Ala Arg 
        115                 120                 125             


Gly His Cys Val Lys Asn Gly Leu His Cys Ala Phe Ala His Gly Pro 
    130                 135                 140                 


Leu Asp Leu Arg Pro Pro Val Cys Asp Val Arg Glu Leu Gln Ala Gln 
145                 150                 155                 160 


Glu Ala Leu Gln Asn Gly Gln Leu Gly Gly Gly Glu Gly Val Pro Asp 
                165                 170                 175     


Leu Gln Pro Gly Val Leu Ala Ser Gln Ala Met Ile Glu Lys Ile Leu 
            180                 185                 190         


Ser Glu Asp Pro Arg Trp Gln Asp Ala Asn Phe Val Leu Gly Ser Tyr 
        195                 200                 205             


Lys Thr Glu Gln Cys Pro Lys Pro Pro Arg Leu Cys Arg Gln Gly Tyr 
    210                 215                 220                 


Ala Cys Pro His Tyr His Asn Ser Arg Asp Arg Arg Arg Asn Pro Arg 
225                 230                 235                 240 


Arg Phe Gln Tyr Ser Trp Gln Leu Gly Arg Arg Val Leu Arg Leu Ser 
                245                 250                 255     


Pro Arg Ala Asn Asn Pro Arg Val Ala Leu Pro Arg Val His Thr Gly 
            260                 265                 270         


Pro Ser Ser Thr Ala 
        275         


<210> 5213
<211> 305
<212> PRT
<213> Homo sapiens

<400> 5213
Met Asp Leu Ser Gly Val Lys Lys Lys Ser Leu Leu Gly Val Lys Glu 
1               5                   10                  15      


Asn Asn Lys Lys Ser Ser Thr Arg Ala Pro Ser Pro Thr Lys Arg Lys 
            20                  25                  30          


Asp Arg Ser Asp Glu Lys Ser Lys Asp Arg Ser Lys Asp Lys Gly Ala 
        35                  40                  45              


Thr Lys Glu Ser Ser Glu Lys Asp Arg Gly Arg Asp Lys Thr Arg Lys 
    50                  55                  60                  


Arg Arg Ser Ala Ser Ser Gly Ser Ser Ser Thr Arg Ser Arg Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Gly Ser Ser Thr Ser Thr Gly Ser Ser Ser Gly 
                85                  90                  95      


Ser Ser Ser Ser Ser Ala Ser Ser Arg Ser Gly Ser Ser Ser Thr Ser 
            100                 105                 110         


Arg Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Pro Ser Pro Ser Arg 
        115                 120                 125             


Arg Arg His Asp Asn Arg Arg Arg Ser Arg Ser Lys Ser Lys Pro Pro 
    130                 135                 140                 


Lys Arg Asp Glu Lys Glu Arg Lys Arg Arg Ser Pro Ser Pro Lys Pro 
145                 150                 155                 160 


Thr Lys Val His Ile Gly Arg Leu Thr Arg Asn Val Thr Lys Asp His 
                165                 170                 175     


Ile Met Glu Ile Phe Ser Thr Tyr Gly Lys Ile Lys Met Ile Asp Met 
            180                 185                 190         


Pro Val Glu Arg Met His Pro His Leu Ser Lys Gly Tyr Ala Tyr Val 
        195                 200                 205             


Glu Phe Glu Asn Pro Asp Glu Ala Glu Lys Ala Leu Lys His Met Asp 
    210                 215                 220                 


Gly Gly Gln Ile Asp Gly Gln Glu Ile Thr Ala Thr Ala Val Leu Ala 
225                 230                 235                 240 


Pro Trp Pro Arg Pro Pro Pro Arg Arg Phe Ser Pro Pro Arg Arg Met 
                245                 250                 255     


Leu Pro Pro Pro Pro Met Trp Arg Arg Ser Pro Pro Arg Met Arg Arg 
            260                 265                 270         


Arg Ser Arg Ser Pro Arg Arg Arg Ser Pro Val Arg Arg Arg Ser Arg 
        275                 280                 285             


Ser Pro Gly Arg Arg Arg His Arg Ser Arg Ser Ser Ser Asn Ser Ser 
    290                 295                 300                 


Arg 
305 


<210> 5214
<211> 1065
<212> PRT
<213> Homo sapiens

<400> 5214
Met Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His 
1               5                   10                  15      


Gly Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu 
            20                  25                  30          


Ala Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp Arg 
        35                  40                  45              


Thr Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln 
    50                  55                  60                  


Arg His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu 
65                  70                  75                  80  


Gly Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu 
                85                  90                  95      


Thr Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr 
            100                 105                 110         


Arg Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe 
        115                 120                 125             


Leu Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile 
    130                 135                 140                 


Gly Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg 
145                 150                 155                 160 


Leu Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro 
                165                 170                 175     


Leu Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg 
            180                 185                 190         


Leu Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val 
        195                 200                 205             


Ala Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys 
    210                 215                 220                 


Arg Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys 
225                 230                 235                 240 


Lys Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn 
                245                 250                 255     


Leu Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser 
            260                 265                 270         


Gly Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly 
        275                 280                 285             


Phe Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu 
    290                 295                 300                 


Asp Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg 
305                 310                 315                 320 


Ala Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly 
                325                 330                 335     


Met Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala 
            340                 345                 350         


Glu Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe 
        355                 360                 365             


Arg Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro 
    370                 375                 380                 


Arg Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr 
                405                 410                 415     


Glu Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly 
            420                 425                 430         


Ala Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser 
        435                 440                 445             


Val Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala 
    450                 455                 460                 


Ala Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr 
465                 470                 475                 480 


Glu Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg 
                485                 490                 495     


Ser Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val 
            500                 505                 510         


Phe Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu 
        515                 520                 525             


Leu Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr 
    530                 535                 540                 


Gln Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val 
545                 550                 555                 560 


Cys Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His 
                565                 570                 575     


Thr Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu 
            580                 585                 590         


Ala Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu 
        595                 600                 605             


Gln Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu 
    610                 615                 620                 


Ser Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu 
                645                 650                 655     


Leu Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser 
            660                 665                 670         


Leu Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg 
        675                 680                 685             


Ser Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn 
    690                 695                 700                 


Ser Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile 
705                 710                 715                 720 


Asn Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn Thr Val Arg Asp 
                725                 730                 735     


Asp Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser Asn Arg Thr Leu 
            740                 745                 750         


Ser Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro Met Gly Ala Gln 
        755                 760                 765             


Arg Met Ala Asp Ala Leu Lys Gln Asn Arg Ser Leu Lys Glu Leu Met 
    770                 775                 780                 


Phe Ser Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys Ala Leu Ala Glu 
785                 790                 795                 800 


Ala Leu Lys Val Asn Gln Gly Leu Glu Ser Leu Asp Leu Gln Ser Asn 
                805                 810                 815     


Ser Ile Ser Asp Ala Gly Val Ala Ala Leu Met Gly Ala Leu Cys Thr 
            820                 825                 830         


Asn Gln Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn Ser Ile Ser Pro 
        835                 840                 845             


Glu Gly Ala Gln Ala Ile Ala His Ala Leu Cys Ala Asn Ser Thr Leu 
    850                 855                 860                 


Lys Asn Leu Asp Leu Thr Ala Asn Leu Leu His Asp Gln Gly Ala Arg 
865                 870                 875                 880 


Ala Ile Ala Val Ala Val Arg Glu Asn Arg Thr Leu Thr Ser Leu His 
                885                 890                 895     


Leu Gln Trp Asn Phe Ile Gln Ala Gly Ala Ala Gln Ala Leu Gly Gln 
            900                 905                 910         


Ala Leu Gln Leu Asn Arg Ser Leu Thr Ser Leu Asp Leu Gln Glu Asn 
        915                 920                 925             


Ala Ile Gly Asp Asp Gly Ala Cys Ala Val Ala Arg Ala Leu Lys Val 
    930                 935                 940                 


Asn Thr Ala Leu Thr Ala Leu Tyr Leu Gln Val Ala Ser Ile Gly Ala 
945                 950                 955                 960 


Ser Gly Ala Gln Val Leu Gly Glu Ala Leu Ala Val Asn Arg Thr Leu 
                965                 970                 975     


Glu Ile Leu Asp Leu Arg Gly Asn Ala Ile Gly Val Ala Gly Ala Lys 
            980                 985                 990         


Ala Leu Ala Asn Ala Leu Lys Val  Asn Ser Ser Leu Arg  Arg Leu Asn 
        995                 1000                 1005             


Leu Gln  Glu Asn Ser Leu Gly  Met Asp Gly Ala Ile  Cys Ile Ala 
    1010                 1015                 1020             


Thr Ala  Leu Ser Gly Asn His  Arg Leu Gln His Ile  Asn Leu Gln 
    1025                 1030                 1035             


Gly Asn  His Ile Gly Asp Ser  Gly Ala Arg Met Ile  Ser Glu Ala 
    1040                 1045                 1050             


Ile Lys  Thr Asn Ala Pro Thr  Cys Thr Val Glu Met  
    1055                 1060                 1065 


<210> 5215
<211> 308
<212> PRT
<213> Homo sapiens

<400> 5215
Met Asn Pro Ile Val Val Val His Gly Gly Gly Ala Gly Pro Ile Ser 
1               5                   10                  15      


Lys Asp Arg Lys Glu Arg Val His Gln Gly Met Val Arg Ala Ala Thr 
            20                  25                  30          


Val Gly Tyr Gly Ile Leu Arg Glu Gly Gly Ser Ala Val Asp Ala Val 
        35                  40                  45              


Glu Gly Ala Val Val Ala Leu Glu Asp Asp Pro Glu Phe Asn Ala Gly 
    50                  55                  60                  


Cys Gly Ser Val Leu Asn Thr Asn Gly Glu Val Glu Met Asp Ala Ser 
65                  70                  75                  80  


Ile Met Asp Gly Lys Asp Leu Ser Ala Gly Ala Val Ser Ala Val Gln 
                85                  90                  95      


Cys Ile Ala Asn Pro Ile Lys Leu Ala Arg Leu Val Met Glu Lys Thr 
            100                 105                 110         


Pro His Cys Phe Leu Thr Asp Gln Gly Ala Ala Gln Phe Ala Ala Ala 
        115                 120                 125             


Met Gly Val Pro Glu Ile Pro Gly Glu Lys Leu Val Thr Glu Arg Asn 
    130                 135                 140                 


Lys Lys Arg Leu Glu Lys Glu Lys His Glu Lys Gly Ala Gln Lys Thr 
145                 150                 155                 160 


Asp Cys Gln Lys Asn Leu Gly Thr Val Gly Ala Val Ala Leu Asp Cys 
                165                 170                 175     


Lys Gly Asn Val Ala Tyr Ala Thr Ser Thr Gly Gly Ile Val Asn Lys 
            180                 185                 190         


Met Val Gly Arg Val Gly Asp Ser Pro Cys Leu Gly Ala Gly Gly Tyr 
        195                 200                 205             


Ala Asp Asn Asp Ile Gly Ala Val Ser Thr Thr Gly His Gly Glu Ser 
    210                 215                 220                 


Ile Leu Lys Val Asn Leu Ala Arg Leu Thr Leu Phe His Ile Glu Gln 
225                 230                 235                 240 


Gly Lys Thr Val Glu Glu Ala Ala Asp Leu Ser Leu Gly Tyr Met Lys 
                245                 250                 255     


Ser Arg Val Lys Gly Leu Gly Gly Leu Ile Val Val Ser Lys Thr Gly 
            260                 265                 270         


Asp Trp Val Ala Lys Trp Thr Ser Thr Ser Met Pro Trp Ala Ala Ala 
        275                 280                 285             


Lys Asp Gly Lys Leu His Phe Gly Ile Asp Pro Asp Asp Thr Thr Ile 
    290                 295                 300                 


Thr Asp Leu Pro 
305             


<210> 5216
<211> 403
<212> PRT
<213> Homo sapiens

<400> 5216
Met Ala Gly Arg Arg Ala Gln Thr Gly Ser Ala Pro Pro Arg Pro Ala 
1               5                   10                  15      


Ala Pro His Pro Pro Ala Ser Arg Ala Phe Pro Gln His Cys Arg Pro 
            20                  25                  30          


Arg Asp Ala Glu Arg Pro Pro Ser Pro Arg Ser Pro Leu Met Pro Gly 
        35                  40                  45              


Cys Glu Leu Pro Val Gly Thr Cys Pro Asp Met Cys Pro Ala Ala Glu 
    50                  55                  60                  


Arg Ala Gln Arg Glu Arg Glu His Arg Leu His Arg Leu Glu Val Val 
65                  70                  75                  80  


Pro Gly Cys Arg Gln Asp Pro Pro Arg Ala Asp Pro Gln Arg Ala Val 
                85                  90                  95      


Lys Glu Tyr Ser Arg Pro Ala Ala Gly Lys Pro Arg Pro Pro Pro Ser 
            100                 105                 110         


Gln Leu Arg Pro Pro Ser Val Leu Leu Ala Thr Val Arg Tyr Leu Ala 
        115                 120                 125             


Gly Glu Val Ala Glu Ser Ala Asp Ile Ala Arg Ala Glu Val Ala Ser 
    130                 135                 140                 


Phe Val Ala Asp Arg Leu Arg Ala Val Leu Leu Asp Leu Ala Leu Gln 
145                 150                 155                 160 


Gly Ala Gly Asp Ala Glu Ala Ala Val Val Leu Glu Ala Ala Leu Ala 
                165                 170                 175     


Thr Leu Leu Thr Val Val Ala Arg Leu Gly Pro Asp Ala Ala Arg Gly 
            180                 185                 190         


Pro Ala Asp Pro Val Leu Leu Gln Ala Gln Val Gln Glu Gly Phe Gly 
        195                 200                 205             


Ser Leu Arg Arg Cys Tyr Ala Arg Gly Ala Gly Pro His Pro Arg Gln 
    210                 215                 220                 


Pro Ala Phe Gln Gly Leu Phe Leu Leu Tyr Asn Leu Gly Ser Val Glu 
225                 230                 235                 240 


Ala Leu His Glu Val Leu Gln Leu Pro Ala Ala Leu Arg Ala Cys Pro 
                245                 250                 255     


Pro Leu Arg Lys Ala Leu Ala Val Asp Ala Ala Phe Arg Glu Gly Asn 
            260                 265                 270         


Ala Ala Arg Leu Phe Arg Leu Leu Gln Thr Leu Pro Tyr Leu Pro Ser 
        275                 280                 285             


Cys Ala Val Gln Cys His Val Gly His Ala Arg Arg Glu Ala Leu Ala 
    290                 295                 300                 


Arg Phe Ala Arg Ala Phe Ser Thr Pro Lys Gly Gln Thr Leu Pro Leu 
305                 310                 315                 320 


Gly Phe Met Val Asn Leu Leu Ala Leu Asp Gly Leu Arg Glu Ala Arg 
                325                 330                 335     


Asp Leu Cys Gln Ala His Gly Leu Pro Leu Asp Gly Glu Glu Arg Val 
            340                 345                 350         


Val Phe Leu Arg Gly Arg Tyr Val Glu Glu Gly Leu Pro Pro Ala Ser 
        355                 360                 365             


Thr Cys Lys Val Leu Val Glu Ser Lys Leu Arg Gly Arg Thr Leu Glu 
    370                 375                 380                 


Glu Val Val Met Ala Glu Glu Glu Asp Glu Gly Thr Asp Arg Pro Gly 
385                 390                 395                 400 


Ser Pro Ala 
            


<210> 5217
<211> 297
<212> PRT
<213> Homo sapiens

<400> 5217
Met Ala Glu Leu Thr Ala Leu Glu Ser Leu Ile Glu Met Gly Phe Pro 
1               5                   10                  15      


Arg Gly Arg Ala Glu Lys Ala Leu Ala Leu Thr Gly Asn Gln Gly Ile 
            20                  25                  30          


Glu Ala Ala Met Asp Trp Leu Met Glu His Glu Asp Asp Pro Asp Val 
        35                  40                  45              


Asp Glu Pro Leu Glu Thr Pro Leu Gly His Ile Leu Gly Arg Glu Pro 
    50                  55                  60                  


Thr Ser Ser Glu Gln Gly Gly Leu Glu Gly Ser Gly Ser Ala Ala Gly 
65                  70                  75                  80  


Glu Gly Lys Pro Ala Leu Ser Glu Glu Glu Arg Gln Glu Gln Thr Lys 
                85                  90                  95      


Arg Met Leu Glu Leu Val Ala Gln Lys Gln Arg Glu Arg Glu Glu Arg 
            100                 105                 110         


Glu Glu Arg Glu Ala Leu Glu Arg Glu Arg Gln Arg Arg Arg Gln Gly 
        115                 120                 125             


Gln Glu Leu Ser Ala Ala Arg Gln Arg Leu Gln Glu Asp Glu Met Arg 
    130                 135                 140                 


Arg Ala Ala Glu Glu Arg Arg Arg Glu Lys Ala Glu Glu Leu Ala Ala 
145                 150                 155                 160 


Arg Gln Arg Val Arg Glu Lys Ile Glu Arg Asp Lys Ala Glu Arg Ala 
                165                 170                 175     


Lys Lys Tyr Gly Gly Ser Val Gly Ser Gln Pro Pro Pro Val Ala Pro 
            180                 185                 190         


Glu Pro Gly Pro Val Pro Ser Ser Pro Ser Gln Glu Pro Pro Thr Lys 
        195                 200                 205             


Arg Glu Tyr Asp Gln Cys Arg Ile Gln Val Arg Leu Pro Asp Gly Thr 
    210                 215                 220                 


Ser Leu Thr Gln Thr Phe Arg Ala Arg Glu Gln Leu Ala Ala Val Arg 
225                 230                 235                 240 


Leu Tyr Val Glu Leu His Arg Gly Glu Glu Leu Gly Gly Gly Gln Asp 
                245                 250                 255     


Pro Val Gln Leu Leu Ser Gly Phe Pro Arg Arg Ala Phe Ser Glu Ala 
            260                 265                 270         


Asp Met Glu Arg Pro Leu Gln Glu Leu Gly Leu Val Pro Ser Ala Val 
        275                 280                 285             


Leu Ile Val Ala Lys Lys Cys Pro Ser 
    290                 295         


<210> 5218
<211> 189
<212> PRT
<213> Homo sapiens

<400> 5218
Met Arg Leu Ser Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ile Pro Gly Gly Leu Gly Asp Arg Ala Pro Leu Thr Ala Thr Ala Pro 
            20                  25                  30          


Gln Leu Asp Asp Glu Glu Met Tyr Ser Ala His Met Pro Ala His Leu 
        35                  40                  45              


Arg Cys Asp Ala Cys Arg Ala Val Ala Tyr Gln Met Trp Gln Asn Leu 
    50                  55                  60                  


Ala Lys Ala Glu Thr Lys Leu His Thr Ser Asn Ser Gly Gly Arg Arg 
65                  70                  75                  80  


Glu Leu Ser Glu Leu Val Tyr Thr Asp Val Leu Asp Arg Ser Cys Ser 
                85                  90                  95      


Arg Asn Trp Gln Asp Tyr Gly Val Arg Glu Val Asp Gln Val Lys Arg 
            100                 105                 110         


Leu Thr Gly Pro Gly Leu Ser Glu Gly Pro Glu Pro Ser Ile Ser Val 
        115                 120                 125             


Met Val Thr Gly Gly Pro Trp Pro Thr Arg Leu Ser Arg Thr Cys Leu 
    130                 135                 140                 


His Tyr Leu Gly Glu Phe Gly Glu Asp Gln Ile Tyr Glu Ala His Gln 
145                 150                 155                 160 


Gln Gly Arg Gly Ala Leu Glu Ala Leu Leu Cys Gly Gly Pro Gln Gly 
                165                 170                 175     


Ala Cys Ser Glu Lys Val Ser Ala Thr Arg Glu Glu Leu 
            180                 185                 


<210> 5219
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 5219
Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Ile Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp 
        115                 120                 125             


Trp Ile Ala Tyr Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ile His His Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Asp Glu Thr Glu Tyr Glu Tyr 
                165                 170                 175     


Ser Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln Glu Gly Glu 
            180                 185                 190         


Pro Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu Arg Arg Asp 
        195                 200                 205             


Phe Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu Ala Leu Arg 
    210                 215                 220                 


Arg Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln Glu Glu Tyr 
225                 230                 235                 240 


Lys Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Gln Gln Lys 
                245                 250                 255     


Glu Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Arg Glu Ala 
            260                 265                 270         


Arg Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln Glu Glu Lys 
        275                 280                 285             


Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu Glu Glu Arg 
    290                 295                 300                 


Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu Gln Glu Tyr 
305                 310                 315                 320 


Ile Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu Val Leu Gln 
                325                 330                 335     


Gln Gln Leu Leu Gln Glu Gln Ala Met Leu Leu Glu Cys Arg Trp Arg 
            340                 345                 350         


Glu Met Glu Glu His Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu Gln 
        355                 360                 365             


Gln Glu Gln Ala Tyr Leu Leu Ser Leu Gln His Asp His Arg Arg Pro 
    370                 375                 380                 


His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln Gln Glu Arg Ser 
385                 390                 395                 400 


Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr Glu Pro Ala 
                405                 410                 415     


Asp Arg Ala Arg Glu Val Pro Val Arg Thr Thr Ser Arg Ser Pro Val 
            420                 425                 430         


Leu Ser Arg Arg Asp Ser Pro Leu Gln Gly Ser Gly Gln Gln Asn Ser 
        435                 440                 445             


Gln Ala Gly Gln Arg Asn Ser Thr Ser Ser Ile Glu Pro Arg Leu Leu 
    450                 455                 460                 


Trp Glu Arg Val Glu Lys Leu Val Pro Arg Pro Gly Ser Gly Ser Ser 
465                 470                 475                 480 


Ser Gly Ser Ser Asn Ser Gly Ser Gln Pro Gly Ser His Pro Gly Ser 
                485                 490                 495     


Gln Ser Gly Ser Gly Glu Arg Phe Arg Val Arg Ser Ser Ser Lys Ser 
            500                 505                 510         


Glu Gly Ser Pro Ser Gln Arg Leu Glu Asn Ala Val Lys Lys Pro Glu 
        515                 520                 525             


Asp Lys Lys Glu Val Phe Arg Pro Leu Lys Pro Ala Val Arg Ile Asp 
    530                 535                 540                 


Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val Glu Asp Val Arg Pro 
545                 550                 555                 560 


Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser Gly Thr 
                565                 570                 575     


Thr Asp Glu Glu Asp Asp Asp Val Glu Gln Glu Gly Ala Asp Glu Ser 
            580                 585                 590         


Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser Ser Leu Asn Leu Ser 
        595                 600                 605             


Asn Gly Glu Thr Glu Ser Val Lys Thr Met Ile Val His Asp Asp Val 
    610                 615                 620                 


Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu Gly Thr Leu Ile Val 
625                 630                 635                 640 


Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu Gln Lys His Lys Ser Ser 
                645                 650                 655     


Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg Leu Leu Gln Ile Ser Pro 
            660                 665                 670         


Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly Phe Ser Cys Asp Gly 
        675                 680                 685             


Met Arg Pro Glu Ala Ile Arg Gln Asp Pro Thr Arg Lys Gly Ser Val 
    690                 695                 700                 


Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gln Ser Asp Thr Pro Glu 
705                 710                 715                 720 


Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu Ile Leu Cys Ala Ala 
                725                 730                 735     


Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu Ser Gly Leu Met Leu 
            740                 745                 750         


Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Pro Leu Ile Asn Arg Arg 
        755                 760                 765             


Arg Phe Gln Gln Met Asp Val Leu Glu Gly Leu Asn Val Leu Val Thr 
    770                 775                 780                 


Ile Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr Tyr Leu Ser Trp Leu 
785                 790                 795                 800 


Arg Asn Lys Ile Leu His Asn Asp Pro Glu Val Glu Lys Lys Gln Gly 
                805                 810                 815     


Trp Thr Thr Val Gly Asp Leu Glu Gly Cys Val His Tyr Lys Val Val 
            820                 825                 830         


Lys Tyr Glu Arg Ile Lys Phe Leu Val Ile Ala Leu Lys Ser Ser Val 
        835                 840                 845             


Glu Val Tyr Ala Trp Ala Pro Lys Pro Tyr His Lys Phe Met Ala Phe 
    850                 855                 860                 


Lys Ser Phe Gly Glu Leu Val His Lys Pro Leu Leu Val Asp Leu Thr 
865                 870                 875                 880 


Val Glu Glu Gly Gln Arg Leu Lys Val Ile Tyr Gly Ser Cys Ala Gly 
                885                 890                 895     


Phe His Ala Val Asp Val Asp Ser Gly Ser Val Tyr Asp Ile Tyr Leu 
            900                 905                 910         


Pro Thr His Ile Gln Cys Ser Ile Lys Pro His Ala Ile Ile Ile Leu 
        915                 920                 925             


Pro Asn Thr Asp Gly Met Glu Leu Leu Val Cys Tyr Glu Asp Glu Gly 
    930                 935                 940                 


Val Tyr Val Asn Thr Tyr Gly Arg Ile Thr Lys Asp Val Val Leu Gln 
945                 950                 955                 960 


Trp Gly Glu Met Pro Thr Ser Val Ala Tyr Ile Arg Ser Asn Gln Thr 
                965                 970                 975     


Met Gly Trp Gly Glu Lys Ala Ile Glu Ile Arg Ser Val Glu Thr Gly 
            980                 985                 990         


His Leu Asp Gly Val Phe Met His  Lys Arg Ala Gln Arg  Leu Lys Phe 
        995                 1000                 1005             


Leu Cys  Glu Arg Asn Asp Lys  Val Phe Phe Ala Ser  Val Arg Ser 
    1010                 1015                 1020             


Gly Gly  Ser Ser Gln Val Tyr  Phe Met Thr Leu Gly  Arg Thr Ser 
    1025                 1030                 1035             


Leu Leu  Ser Trp 
    1040         


<210> 5220
<211> 370
<212> PRT
<213> Homo sapiens

<400> 5220
Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Asn Ala Leu Pro Met 
1               5                   10                  15      


Met Leu Ala Glu Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly 
            20                  25                  30          


Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Glu 
        35                  40                  45              


Pro Ser Asp Arg Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr Tyr Glu 
    50                  55                  60                  


Leu Ala Leu Gln Thr Gly Lys Val Ile Glu Gln Met Gly Lys Phe Tyr 
65                  70                  75                  80  


Pro Glu Leu Lys Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu Glu Arg 
                85                  90                  95      


Gly Gln Lys Ile Ser Glu Gln Ile Val Ile Gly Thr Pro Gly Thr Val 
            100                 105                 110         


Leu Asp Trp Cys Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys Ile Lys 
        115                 120                 125             


Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Ala Thr Gln Gly His 
    130                 135                 140                 


Gln Asp Gln Ser Ile Arg Ile Gln Arg Met Leu Pro Arg Asn Cys Gln 
145                 150                 155                 160 


Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Lys Phe Ala 
                165                 170                 175     


Gln Lys Val Val Pro Asp Pro Asn Val Ile Lys Leu Lys Arg Glu Glu 
            180                 185                 190         


Glu Thr Leu Asp Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser Ser Arg 
        195                 200                 205             


Asp Glu Lys Phe Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile Thr Ile 
    210                 215                 220                 


Ala Gln Ala Met Ile Phe Cys His Thr Arg Lys Thr Ala Ser Trp Leu 
225                 230                 235                 240 


Ala Ala Glu Leu Ser Lys Glu Gly His Gln Val Ala Leu Leu Ser Gly 
                245                 250                 255     


Glu Met Met Val Glu Gln Arg Ala Ala Val Ile Glu Arg Phe Arg Glu 
            260                 265                 270         


Gly Lys Glu Lys Val Leu Val Thr Thr Asn Val Cys Ala Arg Gly Ile 
        275                 280                 285             


Asp Val Glu Gln Val Ser Val Val Ile Asn Phe Asp Leu Pro Val Asp 
    290                 295                 300                 


Lys Asp Gly Asn Pro Asp Asn Glu Thr Tyr Leu His Arg Ile Gly Arg 
305                 310                 315                 320 


Thr Gly Arg Phe Gly Lys Arg Gly Leu Ala Val Asn Met Val Asp Ser 
                325                 330                 335     


Lys His Ser Met Asn Ile Leu Asn Arg Ile Gln Glu His Phe Asn Lys 
            340                 345                 350         


Lys Ile Glu Arg Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu Lys Ile 
        355                 360                 365             


Ala Asn 
    370 


<210> 5221
<211> 478
<212> PRT
<213> Homo sapiens

<400> 5221
Met Ala Thr Asp Ser Trp Ala Leu Ala Val Asp Glu Gln Glu Ala Ala 
1               5                   10                  15      


Val Lys Ser Met Thr Asn Leu Gln Ile Lys Glu Glu Lys Val Lys Ala 
            20                  25                  30          


Asp Thr Asn Gly Ile Ile Lys Thr Ser Thr Thr Ala Glu Lys Thr Asp 
        35                  40                  45              


Glu Glu Glu Lys Glu Asp Arg Ala Ala Gln Ser Leu Leu Asn Lys Leu 
    50                  55                  60                  


Ile Arg Ser Asn Leu Val Asp Asn Thr Asn Gln Val Glu Val Leu Gln 
65                  70                  75                  80  


Arg Asp Pro Asn Ser Pro Leu Tyr Ser Val Lys Ser Phe Glu Glu Leu 
                85                  90                  95      


Arg Leu Lys Pro Gln Leu Leu Gln Gly Val Tyr Ala Met Gly Phe Asn 
            100                 105                 110         


Arg Pro Ser Lys Ile Gln Glu Asn Ala Leu Pro Met Met Leu Ala Glu 
        115                 120                 125             


Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly Thr Gly Lys Thr 
    130                 135                 140                 


Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Glu Pro Ser Asp Arg 
145                 150                 155                 160 


Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr Tyr Glu Leu Ala Leu Gln 
                165                 170                 175     


Thr Gly Lys Val Ile Glu Gln Met Gly Lys Phe Tyr Pro Glu Leu Lys 
            180                 185                 190         


Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu Glu Arg Gly Gln Lys Ile 
        195                 200                 205             


Ser Glu Gln Ile Val Ile Gly Thr Pro Gly Thr Val Leu Asp Trp Cys 
    210                 215                 220                 


Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys Ile Lys Val Phe Val Leu 
225                 230                 235                 240 


Asp Glu Ala Asp Val Met Ile Ala Thr Gln Gly His Gln Asp Gln Ser 
                245                 250                 255     


Ile Arg Ile Gln Arg Met Leu Pro Arg Asn Cys Gln Met Leu Leu Phe 
            260                 265                 270         


Ser Ala Thr Phe Glu Asp Ser Val Trp Lys Phe Ala Gln Lys Val Val 
        275                 280                 285             


Pro Asp Pro Asn Val Ile Lys Leu Lys Arg Glu Glu Glu Thr Leu Asp 
    290                 295                 300                 


Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser Ser Arg Asp Glu Lys Phe 
305                 310                 315                 320 


Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile Thr Ile Ala Gln Ala Met 
                325                 330                 335     


Ile Phe Cys His Thr Arg Lys Thr Ala Ser Trp Leu Ala Ala Glu Leu 
            340                 345                 350         


Ser Lys Glu Gly His Gln Val Ala Leu Leu Ser Gly Glu Met Met Val 
        355                 360                 365             


Glu Gln Arg Ala Ala Val Ile Glu Arg Phe Arg Glu Gly Lys Glu Lys 
    370                 375                 380                 


Val Leu Val Thr Thr Asn Val Cys Ala Arg Gly Ile Asp Val Glu Gln 
385                 390                 395                 400 


Val Ser Val Val Ile Asn Phe Asp Leu Pro Val Asp Lys Asp Gly Asn 
                405                 410                 415     


Pro Asp Asn Glu Thr Tyr Leu His Arg Ile Gly Arg Thr Gly Arg Phe 
            420                 425                 430         


Gly Lys Arg Gly Leu Ala Val Asn Met Val Asp Ser Lys His Ser Met 
        435                 440                 445             


Asn Ile Leu Asn Arg Ile Gln Glu His Phe Asn Lys Lys Ile Glu Arg 
    450                 455                 460                 


Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu Lys Ile Ala Asn 
465                 470                 475             


<210> 5222
<211> 745
<212> PRT
<213> Homo sapiens

<400> 5222
Met Val Gly Pro Gly Pro Thr Ala Ala Ala Ala Val Glu Glu Arg Gln 
1               5                   10                  15      


Arg Lys Leu Gln Glu Tyr Leu Ala Ala Lys Gly Lys Leu Lys Ser Gln 
            20                  25                  30          


Asn Thr Lys Pro Tyr Leu Lys Ser Lys Asn Asn Cys Gln Asn Gln Pro 
        35                  40                  45              


Pro Ser Lys Ser Thr Ile Arg Pro Lys Asn Asp Val Thr Asn His Val 
    50                  55                  60                  


Val Leu Pro Val Lys Pro Lys Arg Ser Ile Ser Ile Lys Leu Gln Pro 
65                  70                  75                  80  


Arg Pro Pro Asn Thr Ala Gly Ser Gln Lys Pro Lys Leu Glu Pro Pro 
                85                  90                  95      


Lys Leu Leu Gly Lys Arg Leu Thr Ser Glu Cys Val Ser Ser Asn Pro 
            100                 105                 110         


Tyr Ser Lys Pro Ser Ser Lys Ser Phe Gln Gln Cys Glu Ala Gly Ser 
        115                 120                 125             


Ser Thr Thr Gly Glu Leu Ser Arg Lys Pro Val Gly Ser Leu Asn Ile 
    130                 135                 140                 


Glu Gln Leu Lys Thr Thr Lys Gln Gln Leu Thr Asp Gln Gly Asn Gly 
145                 150                 155                 160 


Lys Cys Ile Asp Phe Met Asn Asn Ile His Val Glu Asn Glu Ser Leu 
                165                 170                 175     


Asp Asn Phe Leu Lys Glu Thr Asn Lys Glu Asn Leu Leu Asp Ile Leu 
            180                 185                 190         


Thr Glu Pro Glu Arg Lys Pro Asp Pro Lys Leu Tyr Thr Arg Ser Lys 
        195                 200                 205             


Pro Lys Thr Asp Ser Tyr Asn Gln Thr Lys Asn Ser Leu Val Pro Lys 
    210                 215                 220                 


Gln Ala Leu Gly Lys Ser Ser Val Asn Ser Ala Val Leu Lys Asp Arg 
225                 230                 235                 240 


Val Asn Lys Gln Phe Val Gly Glu Thr Gln Ser Arg Thr Phe Pro Val 
                245                 250                 255     


Lys Ser Gln Gln Leu Ser Arg Gly Ala Asp Leu Ala Arg Pro Gly Val 
            260                 265                 270         


Lys Pro Ser Arg Thr Val Pro Ser His Phe Ile Arg Thr Leu Ser Lys 
        275                 280                 285             


Val Gln Ser Ser Lys Lys Pro Val Val Lys Asn Ile Lys Asp Ile Lys 
    290                 295                 300                 


Val Asn Arg Ser Gln Tyr Glu Arg Pro Asn Glu Thr Lys Ile Arg Ser 
305                 310                 315                 320 


Tyr Pro Val Thr Glu Gln Arg Val Lys His Thr Lys Pro Arg Thr Tyr 
                325                 330                 335     


Pro Ser Leu Leu Gln Gly Glu Tyr Asn Asn Arg His Pro Asn Ile Lys 
            340                 345                 350         


Gln Asp Gln Lys Ser Ser Gln Val Cys Ile Pro Gln Thr Ser Cys Val 
        355                 360                 365             


Leu Gln Lys Ser Lys Ala Ile Ser Gln Arg Pro Asn Leu Thr Val Gly 
    370                 375                 380                 


Arg Phe Asn Ser Ala Ile Pro Ser Thr Pro Ser Ile Arg Pro Asn Gly 
385                 390                 395                 400 


Thr Ser Gly Asn Lys His Asn Asn Asn Gly Phe Gln Gln Lys Ala Gln 
                405                 410                 415     


Thr Leu Asp Ser Lys Leu Lys Lys Ala Val Pro Gln Asn His Phe Leu 
            420                 425                 430         


Asn Lys Thr Ala Pro Lys Thr Gln Ala Asp Val Thr Thr Val Asn Gly 
        435                 440                 445             


Thr Gln Thr Asn Pro Asn Ile Lys Lys Lys Ala Thr Ala Glu Asp Arg 
    450                 455                 460                 


Arg Lys Gln Leu Glu Glu Trp Gln Lys Ser Lys Gly Lys Thr Tyr Lys 
465                 470                 475                 480 


Arg Pro Pro Met Glu Leu Lys Thr Lys Arg Lys Val Ile Lys Glu Met 
                485                 490                 495     


Asn Ile Ser Phe Trp Lys Ser Ile Glu Lys Glu Glu Glu Glu Lys Lys 
            500                 505                 510         


Ala Gln Leu Glu Leu Ser Ser Lys Ile Asn Asn Thr Leu Thr Glu Cys 
        515                 520                 525             


Leu Asn Leu Ile Glu Gly Gly Val Pro Ser Asn Glu Ile Leu Asn Ile 
    530                 535                 540                 


Leu Ser Ser Ile Pro Glu Ala Glu Lys Phe Ala Lys Phe Trp Ile Cys 
545                 550                 555                 560 


Lys Ala Lys Leu Leu Ala Ser Lys Gly Thr Phe Asp Val Ile Gly Leu 
                565                 570                 575     


Tyr Glu Glu Ala Ile Lys Asn Gly Ala Thr Pro Ile Gln Glu Leu Arg 
            580                 585                 590         


Lys Val Val Leu Asn Ile Leu Gln Asp Ser Asn Arg Thr Thr Glu Gly 
        595                 600                 605             


Ile Thr Ser Asp Ser Leu Val Ala Glu Thr Ser Ile Thr Ser Val Glu 
    610                 615                 620                 


Glu Leu Ala Lys Lys Met Glu Ser Val Lys Ser Cys Leu Ser Pro Lys 
625                 630                 635                 640 


Glu Arg Glu Gln Val Thr Ala Thr Pro Arg Ile Ala Lys Ala Glu Gln 
                645                 650                 655     


His Asn Tyr Pro Gly Ile Lys Leu Gln Ile Gly Pro Ile Pro Arg Ile 
            660                 665                 670         


Asn Gly Met Pro Glu Val Gln Asp Met Lys Phe Ile Thr Pro Val Arg 
        675                 680                 685             


Arg Ser Ser Arg Ile Glu Arg Ala Val Ser Arg Tyr Pro Glu Met Leu 
    690                 695                 700                 


Gln Glu His Asp Leu Val Val Ala Ser Leu Asp Glu Leu Leu Glu Val 
705                 710                 715                 720 


Glu Glu Thr Lys Cys Phe Ile Phe Arg Arg Asn Glu Ala Leu Pro Val 
                725                 730                 735     


Thr Leu Gly Phe Gln Thr Pro Glu Ser 
            740                 745 


<210> 5223
<211> 125
<212> PRT
<213> Homo sapiens

<400> 5223
Met Ser Ser Thr Leu Gly Lys Leu Ser Asn Gln Val Glu Glu Thr Leu 
1               5                   10                  15      


Pro Leu Leu Lys Lys Val Pro Ala Asn Tyr Phe His Ile Cys Ser Ala 
            20                  25                  30          


Ile Leu Met Gly Phe Ser Leu Ser Lys Ser Ala Thr Gln Val Ser Ala 
        35                  40                  45              


Ile His Met Asp Ser Lys Val Asp Asp His Leu Ile Arg Gly Thr Glu 
    50                  55                  60                  


Lys Ser Arg Leu Glu Pro Ala Thr Gln Leu Phe Gln Asn Thr Lys Lys 
65                  70                  75                  80  


Ile Arg Leu Glu Asp Thr Asn Gln Glu Asn Phe Thr Arg Ile Glu Gly 
                85                  90                  95      


Thr Gly Thr Gly Ser Leu Ser Gly Lys Ala Leu Gly Ser Val Val Tyr 
            100                 105                 110         


Val Lys Glu Ser Asp Gly Leu Glu Met Thr Asp Val Glu 
        115                 120                 125 


<210> 5224
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 5224
Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95      


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110         


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125             


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140                 


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175     


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190         


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205             


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220                 


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240 


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255     


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270         


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285             


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300                 


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320 


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 
                325                 330                 335     


Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala 
            340                 345                 350         


Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu Leu 
        355                 360                 365             


Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser His 
    370                 375                 380                 


Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala Arg Asp Gly His Asp 
385                 390                 395                 400 


Gln His Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met 
                405                 410                 415     


Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 
            420                 425                 430         


Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 
        435                 440                 445             


Ser Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Lys Leu Glu His Ala 
    450                 455                 460                 


Arg Ile Lys Glu Leu Glu Gln Ser Leu Leu Phe Glu Lys Thr Lys Ala 
465                 470                 475                 480 


Asp Lys Leu Gln Arg Glu Leu Glu Asp Thr Arg Val Ala Thr Val Ser 
                485                 490                 495     


Glu Lys Ser Arg Ile Met Glu Leu Glu Lys Asp Leu Ala Leu Arg Val 
            500                 505                 510         


Gln Glu Val Ala Glu Leu Arg Arg Arg Leu Glu Ser Asn Lys Pro Ala 
        515                 520                 525             


Gly Asp Val Asp Met Ser Leu Ser Leu Leu Gln Glu Ile Ser Ser Leu 
    530                 535                 540                 


Gln Glu Lys Leu Glu Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr 
545                 550                 555                 560 


Ser Leu Lys Glu His Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu 
                565                 570                 575     


Ile Lys Ala Leu Tyr Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu 
            580                 585                 590         


Ser Leu Lys Ser Lys Leu Glu His Ala Asn Lys Glu Asn Ser Asp Val 
        595                 600                 605             


Ile Ala Leu Trp Lys Ser Lys Leu Glu Thr Ala Ile Ala Ser His Gln 
    610                 615                 620                 


Gln Ala Met Glu Glu Leu Lys Val Ser Phe Ser Lys Gly Leu Gly Thr 
625                 630                 635                 640 


Glu Thr Ala Glu Phe Ala Glu Leu Lys Thr Gln Ile Glu Lys Met Arg 
                645                 650                 655     


Leu Asp Tyr Gln His Glu Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser 
            660                 665                 670         


Glu Arg Ala Ala His Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu 
        675                 680                 685             


Met Lys Val Ile Lys Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser 
    690                 695                 700                 


Lys Leu Asp Lys Ala Glu Asp Gln His Leu Val Glu Met Glu Asp Thr 
705                 710                 715                 720 


Leu Asn Lys Leu Gln Glu Ala Glu Ile Lys Val Lys Glu Leu Glu Val 
                725                 730                 735     


Leu Gln Ala Lys Cys Asn Glu Gln Thr Lys Val Ile Asp Asn Phe Thr 
            740                 745                 750         


Ser Gln Leu Lys Ala Thr Glu Glu Lys Leu Leu Asp Leu Asp Ala Leu 
        755                 760                 765             


Arg Lys Ala Ser Ser Glu Gly Lys Ser Glu Met Lys Lys Leu Arg Gln 
    770                 775                 780                 


Gln Leu Glu Ala Ala Glu Lys Gln Ile Lys His Leu Glu Ile Glu Lys 
785                 790                 795                 800 


Asn Ala Glu Ser Ser Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly 
                805                 810                 815     


Arg Glu Leu Lys Leu Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser 
            820                 825                 830         


Gln Val Lys Glu Thr Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys 
        835                 840                 845             


Phe Ala Glu Ala Ser Glu Glu Ala Val Ser Val Gln Arg Ser Met Gln 
    850                 855                 860                 


Glu Thr Val Asn Lys Leu His Gln Lys Glu Glu Gln Phe Asn Met Leu 
865                 870                 875                 880 


Ser Ser Asp Leu Glu Lys Leu Arg Glu Asn Leu Ala Asp Met Glu Ala 
                885                 890                 895     


Lys Phe Arg Glu Lys Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys 
            900                 905                 910         


Glu Lys Leu Glu Asn Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp 
        915                 920                 925             


Asn Ser Ser Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu 
    930                 935                 940                 


Arg Asp Val Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn 
945                 950                 955                 960 


Ala Ser Phe Leu Gln Lys Ser Ile Glu Asp Met Thr Val Lys Ala Glu 
                965                 970                 975     


Gln Ser Gln Gln Glu Ala Ala Lys Lys His Glu Glu Glu Lys Lys Glu 
            980                 985                 990         


Leu Glu Arg Lys Leu Ser Asp Leu  Glu Lys Lys Met Glu  Thr Ser His 
        995                 1000                 1005             


Asn Gln  Cys Gln Glu Leu Lys  Ala Arg Tyr Glu Arg  Ala Thr Ser 
    1010                 1015                 1020             


Glu Thr  Lys Thr Lys His Glu  Glu Ile Leu Gln Asn  Leu Gln Lys 
    1025                 1030                 1035             


Thr Leu  Leu Asp Thr Glu Asp  Lys Leu Lys Gly Ala  Arg Glu Glu 
    1040                 1045                 1050             


Asn Ser  Gly Leu Leu Gln Glu  Leu Glu Glu Leu Arg  Lys Gln Ala 
    1055                 1060                 1065             


Asp Lys  Ala Lys Ala Ala Gln  Thr Ala Glu Asp Ala  Met Gln Ile 
    1070                 1075                 1080             


Met Glu  Gln Met Thr Lys Glu  Lys Thr Glu Thr Leu  Ala Ser Leu 
    1085                 1090                 1095             


Glu Asp  Thr Lys Gln Thr Asn  Ala Lys Leu Gln Asn  Glu Leu Asp 
    1100                 1105                 1110             


Thr Leu  Lys Glu Asn Asn Leu  Lys Asn Val Glu Glu  Leu Asn Lys 
    1115                 1120                 1125             


Ser Lys  Glu Leu Leu Thr Val  Glu Asn Gln Lys Met  Glu Glu Phe 
    1130                 1135                 1140             


Arg Lys  Glu Ile Glu Thr Leu  Lys Gln Ala Ala Ala  Gln Lys Ser 
    1145                 1150                 1155             


Gln Gln  Leu Ser Ala Leu Gln  Glu Glu Asn Val Lys  Leu Ala Glu 
    1160                 1165                 1170             


Glu Leu  Gly Arg Ser Arg Asp  Glu Val Thr Ser His  Gln Lys Leu 
    1175                 1180                 1185             


Glu Glu  Glu Arg Ser Val Leu  Asn Asn Gln Leu Leu  Glu Met Lys 
    1190                 1195                 1200             


Lys Arg  Glu Ser Lys Phe Ile  Lys Asp Ala Asp Glu  Glu Lys Ala 
    1205                 1210                 1215             


Ser Leu  Gln Lys Ser Ile Ser  Ile Thr Ser Ala Leu  Leu Thr Glu 
    1220                 1225                 1230             


Lys Asp  Ala Glu Leu Glu Lys  Leu Arg Asn Glu Val  Thr Val Leu 
    1235                 1240                 1245             


Arg Gly  Glu Asn Ala Ser Ala  Lys Ser Leu His Ser  Val Val Gln 
    1250                 1255                 1260             


Thr Leu  Glu Ser Asp Lys Val  Lys Leu Glu Leu Lys  Val Lys Asn 
    1265                 1270                 1275             


Leu Glu  Leu Gln Leu Lys Glu  Asn Lys Arg Gln Leu  Ser Ser Ser 
    1280                 1285                 1290             


Ser Gly  Asn Thr Asp Thr Gln  Ala Asp Glu Asp Glu  Arg Ala Gln 
    1295                 1300                 1305             


Glu Ser  Gln Ile Asp Phe Leu  Asn Ser Val Ile Val  Asp Leu Gln 
    1310                 1315                 1320             


Arg Lys  Asn Gln Asp Leu Lys  Met Lys Val Glu Met  Met Ser Glu 
    1325                 1330                 1335             


Ala Ala  Leu Asn Gly Asn Gly  Asp Asp Leu Asn Asn  Tyr Asp Ser 
    1340                 1345                 1350             


Asp Asp  Gln Glu Lys Gln Ser  Lys Lys Lys Pro Arg  Leu Phe Cys 
    1355                 1360                 1365             


Asp Ile  Cys Asp Cys Phe Asp  Leu His Asp Thr Glu  Asp Cys Pro 
    1370                 1375                 1380             


Thr Gln  Ala Gln Met Ser Glu  Asp Pro Pro His Ser  Thr His His 
    1385                 1390                 1395             


Gly Ser  Arg Gly Glu Glu Arg  Pro Tyr Cys Glu Ile  Cys Glu Met 
    1400                 1405                 1410             


Phe Gly  His Trp Ala Thr Asn  Cys Asn Asp Asp Glu  Thr Phe 
    1415                 1420                 1425         


<210> 5225
<211> 324
<212> PRT
<213> Homo sapiens

<400> 5225
Met Ala Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr 
1               5                   10                  15      


Ser Ile Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu 
            20                  25                  30          


Gly Asp Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr 
        35                  40                  45              


Lys Ala Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg 
    50                  55                  60                  


Lys Phe Pro Lys Leu Thr Ile Ile Gly Glu Glu Asp Leu Pro Ser Glu 
65                  70                  75                  80  


Glu Val Asp Gln Glu Leu Ile Glu Asp Ser Gln Trp Glu Glu Ile Leu 
                85                  90                  95      


Lys Gln Pro Cys Pro Ser Gln Tyr Ser Ala Ile Lys Glu Glu Asp Leu 
            100                 105                 110         


Val Val Trp Val Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly 
        115                 120                 125             


Leu Leu Asp Asn Val Thr Val Leu Ile Gly Ile Ala Tyr Glu Gly Lys 
    130                 135                 140                 


Ala Ile Ala Gly Val Ile Asn Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly 
145                 150                 155                 160 


Pro Asp Ala Val Leu Gly Arg Thr Ile Trp Gly Val Leu Gly Leu Gly 
                165                 170                 175     


Ala Phe Gly Phe Gln Leu Lys Glu Val Pro Ala Gly Lys His Ile Ile 
            180                 185                 190         


Thr Thr Thr Arg Ser His Ser Asn Lys Leu Val Thr Asp Cys Val Ala 
        195                 200                 205             


Ala Met Asn Pro Asp Ala Val Leu Arg Val Gly Gly Ala Gly Asn Lys 
    210                 215                 220                 


Ile Ile Gln Leu Ile Glu Gly Lys Ala Ser Ala Tyr Val Phe Ala Ser 
225                 230                 235                 240 


Pro Gly Cys Lys Lys Trp Asp Thr Cys Ala Pro Glu Val Ile Leu His 
                245                 250                 255     


Ala Val Gly Gly Lys Leu Thr Asp Ile His Gly Asn Val Leu Gln Tyr 
            260                 265                 270         


His Lys Gly Val Ser His Arg Thr Trp Pro Lys Pro Asp Phe Phe Arg 
        275                 280                 285             


Ala Gln Phe Phe Leu Glu Ser His Ser Cys Phe Ser Asn Phe Lys Asn 
    290                 295                 300                 


Val Ser Thr Pro Ile Lys Asn Ile Tyr Asp Val Ile Ile Tyr Ala Tyr 
305                 310                 315                 320 


Glu Thr Asp Leu 
                


<210> 5226
<211> 89
<212> PRT
<213> Homo sapiens

<400> 5226
Met Gly Thr Lys Arg Glu Ala Ile Leu Lys Val Leu Glu Asn Leu Thr 
1               5                   10                  15      


Pro Glu Glu Leu Lys Lys Phe Lys Met Lys Leu Gly Thr Val Pro Leu 
            20                  25                  30          


Arg Glu Gly Phe Glu Arg Ile Pro Arg Gly Ala Leu Gly Gln Leu Asp 
        35                  40                  45              


Ile Val Asp Leu Thr Asp Lys Leu Val Ala Ser Tyr Tyr Glu Asp Tyr 
    50                  55                  60                  


Ala Ala Glu Leu Val Val Ala Val Leu Arg Asp Met Arg Met Leu Glu 
65                  70                  75                  80  


Glu Ala Ala Arg Leu Gln Arg Ala Ala 
                85                  


<210> 5227
<211> 288
<212> PRT
<213> Homo sapiens

<400> 5227
Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
1               5                   10                  15      


Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
            20                  25                  30          


Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
        35                  40                  45              


Arg Lys Ile Lys Pro Lys Asn Ser Lys Gln Ala Glu Arg Glu Glu Lys 
    50                  55                  60                  


Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
65                  70                  75                  80  


Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                85                  90                  95      


Leu Ala Gly Ala Ala Gly Gly Pro Gly Ile Gly Arg Ala Ala Gly Arg 
            100                 105                 110         


Gly Ile Pro Ala Gly Val Pro Met Pro Gln Ala Pro Ala Gly Leu Ala 
        115                 120                 125             


Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
    130                 135                 140                 


Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser 
145                 150                 155                 160 


Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Gly Pro Pro 
                165                 170                 175     


Pro Pro Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly Pro Pro 
            180                 185                 190         


Pro Gly Met Arg Pro Pro Met Gly Pro Pro Met Gly Ile Pro Pro Gly 
        195                 200                 205             


Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
    210                 215                 220                 


Pro Gly Cys Glu Ala Phe Phe Asp Pro Trp Pro Gln Ser Met Glu Val 
225                 230                 235                 240 


Ala Pro Gln Arg Arg Gly Leu Asp Ser Ser Gly Pro Arg Tyr His Arg 
                245                 250                 255     


Pro Val Cys Phe Leu Cys Cys Cys Ser Trp Ser Leu Met Gly Leu Ser 
            260                 265                 270         


Gly Phe Leu Thr Gly Pro Pro Pro Pro Gly Met Arg Pro Pro Arg Pro 
        275                 280                 285             


<210> 5228
<211> 1099
<212> PRT
<213> Homo sapiens

<400> 5228
Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln 
1               5                   10                  15      


Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly 
            20                  25                  30          


Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu 
        35                  40                  45              


Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser 
65                  70                  75                  80  


Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu 
                85                  90                  95      


Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg 
            100                 105                 110         


Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln 
        115                 120                 125             


Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu 
    130                 135                 140                 


Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu 
145                 150                 155                 160 


Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr 
                165                 170                 175     


Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu 
            180                 185                 190         


Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln 
        195                 200                 205             


Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met 
    210                 215                 220                 


Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met 
                245                 250                 255     


Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys 
            260                 265                 270         


Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys 
        275                 280                 285             


Asp Lys Glu Thr Gly Gly Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala 
    290                 295                 300                 


Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys 
                325                 330                 335     


Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Val 
            340                 345                 350         


Lys Lys Ile Thr Asp Gly Leu His Ala Leu Gln Glu Ala Ser Asn Lys 
        355                 360                 365             


Asp Ala Glu Ala Leu Ala Ala Ala Gln Gln His Phe Asn Ala Val Ser 
    370                 375                 380                 


Ala Gly Leu Ser Ser Asn Glu Asp Gly Ala Glu Ala Thr Leu Ala Gly 
385                 390                 395                 400 


Gln Met Met Ala Cys Lys Asn Asp Ile Ser Lys Ala Gln Thr Glu Ala 
                405                 410                 415     


Lys Gln Ala Gln Met Lys Leu Lys His Ala Gln Gln Glu Leu Lys Asn 
            420                 425                 430         


Lys Gln Ala Glu Val Lys Lys Met Asp Ser Gly Tyr Arg Lys Asp Gln 
        435                 440                 445             


Glu Ala Leu Glu Ala Val Lys Arg Leu Lys Glu Lys Leu Glu Ala Glu 
    450                 455                 460                 


Met Lys Lys Leu Asn Tyr Glu Glu Asn Lys Glu Glu Ser Leu Leu Glu 
465                 470                 475                 480 


Lys Arg Arg Gln Leu Ser Arg Asp Ile Gly Arg Leu Lys Glu Thr Tyr 
                485                 490                 495     


Glu Ala Leu Leu Ala Arg Phe Pro Asn Leu Arg Phe Ala Tyr Lys Asp 
            500                 505                 510         


Pro Glu Lys Asn Trp Asn Arg Asn Cys Val Lys Gly Leu Val Ala Ser 
        515                 520                 525             


Leu Ile Ser Val Lys Asp Thr Ser Ala Thr Thr Ala Leu Glu Leu Val 
    530                 535                 540                 


Ala Gly Glu Arg Leu Tyr Asn Val Val Val Asp Thr Glu Val Thr Gly 
545                 550                 555                 560 


Lys Lys Leu Leu Glu Arg Gly Glu Leu Lys Arg Arg Tyr Thr Ile Ile 
                565                 570                 575     


Pro Leu Asn Lys Ile Ser Ala Arg Cys Ile Ala Pro Glu Thr Leu Arg 
            580                 585                 590         


Val Ala Gln Asn Leu Val Gly Pro Asp Asn Val His Val Ala Leu Ser 
        595                 600                 605             


Leu Val Glu Tyr Lys Pro Glu Leu Gln Lys Ala Met Glu Phe Val Phe 
    610                 615                 620                 


Gly Thr Thr Phe Val Cys Asp Asn Met Asp Asn Ala Lys Lys Val Ala 
625                 630                 635                 640 


Phe Asp Lys Arg Ile Met Thr Arg Thr Val Thr Leu Gly Gly Asp Val 
                645                 650                 655     


Phe Asp Pro His Gly Thr Leu Ser Gly Gly Ala Arg Ser Gln Ala Ala 
            660                 665                 670         


Ser Ile Leu Thr Lys Phe Gln Glu Leu Lys Asp Val Gln Asp Glu Leu 
        675                 680                 685             


Arg Ile Lys Glu Asn Glu Leu Arg Ala Leu Glu Glu Glu Leu Ala Gly 
    690                 695                 700                 


Leu Lys Asn Thr Ala Glu Lys Tyr Arg Gln Leu Lys Gln Gln Trp Glu 
705                 710                 715                 720 


Met Lys Thr Glu Glu Ala Asp Leu Leu Gln Thr Lys Leu Gln Gln Ser 
                725                 730                 735     


Ser Tyr His Lys Gln Gln Glu Glu Leu Asp Ala Leu Lys Lys Thr Ile 
            740                 745                 750         


Glu Glu Ser Glu Glu Thr Leu Lys Asn Thr Lys Glu Ile Gln Arg Lys 
        755                 760                 765             


Ala Glu Glu Lys Tyr Glu Val Leu Glu Asn Lys Met Lys Asn Ala Glu 
    770                 775                 780                 


Ala Glu Arg Glu Arg Glu Leu Lys Asp Ala Gln Lys Lys Leu Asp Cys 
785                 790                 795                 800 


Ala Lys Thr Lys Ala Asp Ala Ser Ser Lys Lys Met Lys Glu Lys Gln 
                805                 810                 815     


Gln Glu Val Glu Ala Ile Thr Leu Glu Leu Glu Glu Leu Lys Arg Glu 
            820                 825                 830         


His Thr Ser Tyr Lys Gln Gln Leu Glu Ala Val Asn Glu Ala Ile Lys 
        835                 840                 845             


Ser Tyr Glu Ser Gln Ile Glu Val Met Ala Ala Glu Val Ala Lys Asn 
    850                 855                 860                 


Lys Glu Ser Val Asn Lys Ala Gln Glu Glu Val Thr Lys Gln Lys Glu 
865                 870                 875                 880 


Val Ile Thr Ala Gln Asp Thr Val Ile Lys Ala Lys Tyr Ala Glu Val 
                885                 890                 895     


Ala Lys His Lys Glu Gln Asn Asn Asp Ser Gln Leu Lys Ile Lys Glu 
            900                 905                 910         


Leu Asp His Asn Ile Ser Lys His Lys Arg Glu Ala Glu Asp Gly Ala 
        915                 920                 925             


Ala Lys Val Ser Lys Met Leu Lys Asp Tyr Asp Trp Ile Asn Ala Glu 
    930                 935                 940                 


Arg His Leu Phe Gly Gln Pro Asn Ser Ala Tyr Asp Phe Lys Thr Asn 
945                 950                 955                 960 


Asn Pro Lys Glu Ala Gly Gln Arg Leu Gln Lys Leu Gln Glu Met Lys 
                965                 970                 975     


Glu Lys Leu Gly Arg Asn Val Asn Met Arg Ala Met Asn Val Leu Thr 
            980                 985                 990         


Glu Ala Glu Glu Arg Tyr Asn Asp  Leu Met Lys Lys Lys  Arg Ile Val 
        995                 1000                 1005             


Glu Asn  Asp Lys Ser Lys Ile  Leu Thr Thr Ile Glu  Asp Leu Asp 
    1010                 1015                 1020             


Gln Lys  Lys Asn Gln Ala Leu  Asn Ile Ala Trp Gln  Lys Val Asn 
    1025                 1030                 1035             


Lys Asp  Phe Gly Ser Ile Phe  Ser Thr Leu Leu Pro  Gly Ala Asn 
    1040                 1045                 1050             


Ala Met  Leu Ala Pro Pro Glu  Gly Gln Thr Val Leu  Asp Gly Leu 
    1055                 1060                 1065             


Glu Phe  Lys Val Ala Leu Gly  Asn Thr Trp Lys Glu  Asn Leu Thr 
    1070                 1075                 1080             


Glu Leu  Ser Gly Gly Gln Arg  Gln Lys Gln Gln Asn  His Thr Thr 
    1085                 1090                 1095             


Gly 
    


<210> 5229
<211> 126
<212> PRT
<213> Homo sapiens

<400> 5229
Met Phe Gln Lys Asp Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn 
1               5                   10                  15      


Ala Gly Lys Thr Thr Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys 
            20                  25                  30          


Asn Tyr Lys Gly Met Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu 
        35                  40                  45              


Asn Ile Gly Thr Val Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp 
    50                  55                  60                  


Leu Gly Gly Gln Glu Glu Leu Gln Ser Leu Trp Asp Lys Asp Lys Thr 
65                  70                  75                  80  


Lys Cys Gly Asp Leu Gly Thr Leu His Ser Ser Lys Val Ser Ala Ser 
                85                  90                  95      


Phe Arg Leu Arg Asp Leu Ala Ala Asp His His Arg Thr Gln Lys Trp 
            100                 105                 110         


Gln Arg Pro Asp Val Gly Thr Ala Gly Trp Leu Pro Leu Pro 
        115                 120                 125     


<210> 5230
<211> 372
<212> PRT
<213> Homo sapiens

<400> 5230
Met Thr Phe Gln Phe Asn Phe Thr Ile Glu Asp His Leu Glu Asn Glu 
1               5                   10                  15      


Leu Thr Pro Ile Arg Asp Gly Ala Leu Thr Leu Asp Ser Ser Lys Glu 
            20                  25                  30          


Leu Ser Val Ser Glu Ser Gln Lys Gly Glu Glu Arg Asp Arg Lys Cys 
        35                  40                  45              


Ser Ala Glu Gln Phe Asp Leu Pro Gln Asp His Leu Trp Glu His Lys 
    50                  55                  60                  


Ser Met Glu Asn Ala Ala Pro Ser Gln Asp Thr Asp Ser Pro Leu Ser 
65                  70                  75                  80  


Ala Ala Ser Ser Ser Arg Asn Leu Glu Pro His Gly Lys Gln Pro Ser 
                85                  90                  95      


Leu Arg Ala Ala Lys Glu His Ala Met Pro Lys Asp Leu Lys Lys Met 
            100                 105                 110         


Leu Glu Asn Lys Val Ile Glu Thr Leu Pro Gly Phe Gln His Val Lys 
        115                 120                 125             


Leu Ser Val Val Lys Thr Ile Leu Leu Lys Glu Asn Phe Pro Gly Glu 
    130                 135                 140                 


Asn Ile Val Ser Lys Ser Phe Ser Ser His Ser Asp Leu Ile Thr Gly 
145                 150                 155                 160 


Val Tyr Glu Gly Gly Leu Lys Ile Trp Glu Cys Thr Phe Asp Leu Leu 
                165                 170                 175     


Ala Tyr Phe Thr Lys Ala Lys Val Lys Phe Ala Gly Lys Lys Val Leu 
            180                 185                 190         


Asp Leu Gly Cys Gly Ser Gly Leu Leu Gly Ile Thr Ala Phe Lys Gly 
        195                 200                 205             


Gly Ser Lys Glu Ile His Phe Gln Asp Tyr Asn Ser Met Val Ile Asp 
    210                 215                 220                 


Glu Val Thr Leu Pro Asn Val Val Ala Asn Ser Thr Leu Glu Asp Glu 
225                 230                 235                 240 


Glu Asn Asp Val Asn Glu Pro Asp Val Lys Arg Cys Arg Lys Pro Lys 
                245                 250                 255     


Val Thr Gln Leu Tyr Lys Cys Arg Phe Phe Ser Gly Glu Trp Ser Glu 
            260                 265                 270         


Phe Cys Lys Leu Val Leu Ser Ser Glu Lys Leu Phe Val Lys Tyr Asp 
        275                 280                 285             


Leu Ile Leu Thr Ser Glu Thr Ile Tyr Asn Pro Asp Tyr Tyr Ser Asn 
    290                 295                 300                 


Leu His Gln Thr Phe Leu Arg Leu Leu Ser Lys Asn Gly Arg Val Leu 
305                 310                 315                 320 


Leu Ala Ser Lys Ala His Tyr Phe Gly Val Gly Gly Gly Val His Leu 
                325                 330                 335     


Phe Gln Lys Phe Val Glu Glu Arg Asp Val Phe Lys Thr Arg Ile Leu 
            340                 345                 350         


Lys Ile Ile Asp Glu Gly Leu Lys Arg Phe Ile Ile Glu Ile Thr Phe 
        355                 360                 365             


Lys Phe Pro Gly 
    370         


<210> 5231
<211> 544
<212> PRT
<213> Homo sapiens

<400> 5231
Met Lys Cys His Tyr Glu Ala Leu Gly Val Arg Arg Asp Ala Ser Glu 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Leu Asp Asn Ala Ala Glu Ala Ala Glu Gln Phe Lys Leu 
        35                  40                  45              


Ile Gln Ala Ala Tyr Asp Val Leu Ser Asp Pro Gln Glu Arg Ala Trp 
    50                  55                  60                  


Tyr Asp Asn His Arg Glu Ala Leu Leu Lys Gly Gly Phe Asp Gly Glu 
65                  70                  75                  80  


Tyr Gln Asp Asp Ser Leu Asp Leu Leu Arg Tyr Phe Thr Val Thr Cys 
                85                  90                  95      


Tyr Ser Gly Tyr Gly Asp Asp Glu Lys Gly Phe Tyr Thr Val Tyr Arg 
            100                 105                 110         


Asn Val Phe Glu Met Ile Ala Lys Glu Glu Leu Glu Ser Val Leu Glu 
        115                 120                 125             


Glu Glu Val Asp Asp Phe Pro Thr Phe Gly Asp Ser Gln Ser Asp Tyr 
    130                 135                 140                 


Asp Thr Val Val His Pro Phe Tyr Ala Tyr Trp Gln Ser Phe Cys Thr 
145                 150                 155                 160 


Gln Lys Asn Phe Ala Trp Lys Glu Glu Tyr Asp Thr Arg Gln Ala Ser 
                165                 170                 175     


Asn Arg Trp Glu Lys Arg Ala Met Glu Lys Glu Asn Lys Lys Ile Arg 
            180                 185                 190         


Asp Lys Ala Arg Lys Glu Lys Asn Glu Leu Val Arg Gln Leu Val Ala 
        195                 200                 205             


Phe Ile Arg Lys Arg Asp Lys Arg Val Gln Ala His Arg Lys Leu Val 
    210                 215                 220                 


Glu Glu Gln Asn Ala Glu Lys Ala Arg Lys Ala Glu Glu Met Arg Arg 
225                 230                 235                 240 


Gln Gln Lys Leu Lys Gln Ala Lys Leu Val Glu Gln Tyr Arg Glu Gln 
                245                 250                 255     


Ser Trp Met Thr Met Ala Asn Leu Glu Lys Glu Leu Gln Glu Met Glu 
            260                 265                 270         


Ala Arg Tyr Glu Lys Glu Phe Gly Asp Gly Ser Asp Glu Asn Glu Met 
        275                 280                 285             


Glu Glu His Glu Leu Lys Asp Glu Glu Asp Gly Lys Asp Ser Asp Glu 
    290                 295                 300                 


Ala Glu Asp Ala Glu Leu Tyr Asp Asp Leu Tyr Cys Pro Ala Cys Asp 
305                 310                 315                 320 


Lys Ser Phe Lys Thr Glu Lys Ala Met Lys Asn His Glu Lys Ser Lys 
                325                 330                 335     


Lys His Arg Glu Met Val Ala Leu Leu Lys Gln Gln Leu Glu Glu Glu 
            340                 345                 350         


Glu Glu Asn Phe Ser Arg Pro Gln Ile Asp Glu Asn Pro Leu Asp Asp 
        355                 360                 365             


Asn Ser Glu Glu Glu Met Glu Asp Ala Pro Lys Gln Lys Val Lys Tyr 
    370                 375                 380                 


Leu Thr Phe Arg Phe Ile Phe Ala Leu Arg Leu Ser Lys Lys Gln Lys 
385                 390                 395                 400 


Lys Lys Lys Gln Lys Pro Ala Gln Asn Tyr Asp Asp Asn Phe Asn Val 
                405                 410                 415     


Asn Gly Pro Gly Glu Gly Val Lys Val Asp Pro Glu Asp Thr Asn Leu 
            420                 425                 430         


Asn Gln Asp Ser Ala Lys Glu Leu Glu Asp Ser Pro Gln Glu Asn Val 
        435                 440                 445             


Ser Val Thr Glu Ile Ile Lys Pro Cys Asp Asp Pro Lys Ser Glu Ala 
    450                 455                 460                 


Lys Ser Val Pro Lys Pro Lys Gly Lys Lys Thr Lys Asp Met Lys Lys 
465                 470                 475                 480 


Pro Val Arg Val Pro Ala Glu Pro Gln Thr Met Ser Val Leu Ile Ser 
                485                 490                 495     


Cys Thr Thr Cys His Ser Glu Phe Pro Ser Arg Asn Lys Leu Phe Asp 
            500                 505                 510         


His Leu Lys Ala Thr Gly His Ala Arg Ala Pro Ser Ser Ser Ser Leu 
        515                 520                 525             


Asn Ser Ala Thr Ser Ser Gln Ser Lys Lys Glu Lys Arg Lys Asn Arg 
    530                 535                 540                 


<210> 5232
<211> 314
<212> PRT
<213> Homo sapiens

<400> 5232
Met Pro Gly Phe Thr Cys Cys Val Pro Gly Cys Tyr Asn Asn Ser His 
1               5                   10                  15      


Arg Asp Lys Ala Leu His Phe Tyr Thr Phe Pro Lys Asp Ala Glu Leu 
            20                  25                  30          


Arg Arg Leu Trp Leu Lys Asn Val Ser Arg Ala Gly Val Ser Gly Cys 
        35                  40                  45              


Phe Ser Thr Phe Gln Pro Thr Thr Gly His Arg Leu Cys Ser Val His 
    50                  55                  60                  


Phe Gln Gly Gly Arg Lys Thr Tyr Thr Val Arg Val Pro Thr Ile Phe 
65                  70                  75                  80  


Pro Leu Arg Gly Val Asn Glu Arg Lys Val Ala Arg Arg Pro Ala Gly 
                85                  90                  95      


Ala Ala Ala Ala Arg Arg Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln Gln Ser Ser Pro Ser Ala Ser Thr Ala Gln Thr Ala Gln 
    130                 135                 140                 


Leu Gln Pro Asn Leu Val Ser Ala Ser Ala Ala Val Leu Leu Thr Leu 
145                 150                 155                 160 


Gln Ala Thr Val Asp Ser Ser Gln Ala Pro Gly Ser Val Gln Pro Ala 
                165                 170                 175     


Pro Ile Thr Pro Thr Gly Glu Asp Val Lys Pro Ile Asp Leu Thr Val 
            180                 185                 190         


Gln Val Glu Phe Ala Ala Ala Glu Gly Ala Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Ser Glu Leu Gln Ala Ala Thr Ala Gly Leu Glu Ala Ala Glu Cys Pro 
    210                 215                 220                 


Met Gly Pro Gln Leu Val Val Val Gly Glu Glu Gly Phe Pro Asp Thr 
225                 230                 235                 240 


Gly Ser Asp His Ser Tyr Ser Leu Ser Ser Gly Thr Thr Glu Glu Glu 
                245                 250                 255     


Leu Leu Arg Lys Leu Asn Glu Gln Arg Asp Ile Leu Ala Leu Met Glu 
            260                 265                 270         


Val Lys Met Lys Glu Met Lys Gly Ser Ile Arg His Leu Arg Leu Thr 
        275                 280                 285             


Glu Ala Lys Leu Arg Glu Glu Leu Arg Glu Lys Asp Arg Leu Leu Ala 
    290                 295                 300                 


Met Ala Val Ile Arg Lys Lys His Gly Met 
305                 310                 


<210> 5233
<211> 214
<212> PRT
<213> Homo sapiens

<400> 5233
Met Ala Gly Glu Asn Phe Ala Thr Pro Phe His Gly His Val Gly Arg 
1               5                   10                  15      


Gly Ala Phe Ser Asp Val Tyr Glu Pro Ala Glu Asp Thr Phe Leu Leu 
            20                  25                  30          


Leu Asn Ala Leu Glu Ala Ala Ala Ala Glu Leu Ala Gly Val Glu Ile 
        35                  40                  45              


Cys Leu Glu Val Gly Ser Gly Ser Gly Val Val Ser Ala Phe Leu Ala 
    50                  55                  60                  


Ser Met Ile Gly Pro Gln Ala Leu Tyr Met Cys Thr Asp Ile Asn Pro 
65                  70                  75                  80  


Glu Ala Ala Ala Cys Thr Leu Glu Thr Ala Arg Cys Asn Lys Val His 
                85                  90                  95      


Ile Gln Pro Val Ile Thr Asp Leu Val Lys Gly Leu Leu Pro Arg Leu 
            100                 105                 110         


Thr Glu Lys Val Asp Leu Leu Val Phe Asn Pro Pro Tyr Val Val Thr 
        115                 120                 125             


Pro Pro Gln Glu Val Gly Ser His Gly Ile Glu Ala Ala Trp Ala Gly 
    130                 135                 140                 


Gly Lys Asn Gly Arg Glu Val Met Asp Arg Phe Phe Pro Leu Val Pro 
145                 150                 155                 160 


Asp Leu Leu Ser Pro Lys Gly Leu Phe Tyr Leu Val Thr Ile Lys Glu 
                165                 170                 175     


Asn Asn Pro Glu Glu Ile Leu Lys Ile Met Lys Thr Lys Gly Leu Gln 
            180                 185                 190         


Gly Thr Thr Ala Leu Ser Arg Gln Ala Gly Gln Glu Thr Leu Ser Val 
        195                 200                 205             


Leu Lys Phe Thr Lys Ser 
    210                 


<210> 5234
<211> 511
<212> PRT
<213> Homo sapiens

<400> 5234
Met Ser Gly Gly Phe Glu Leu Gln Pro Arg Asp Gly Gly Pro Arg Val 
1               5                   10                  15      


Ala Leu Ala Pro Gly Glu Thr Val Ile Gly Arg Gly Pro Leu Leu Gly 
            20                  25                  30          


Ile Thr Asp Lys Arg Val Ser Arg Arg His Ala Ile Leu Glu Val Ala 
        35                  40                  45              


Gly Gly Gln Leu Arg Ile Lys Pro Ile His Thr Asn Pro Cys Phe Tyr 
    50                  55                  60                  


Gln Ser Ser Glu Lys Ser Gln Leu Leu Pro Leu Lys Pro Asn Leu Trp 
65                  70                  75                  80  


Cys Tyr Leu Asn Pro Gly Asp Ser Phe Ser Leu Leu Val Asp Lys Tyr 
                85                  90                  95      


Ile Phe Arg Ile Leu Ser Ile Pro Ser Glu Val Glu Met Gln Cys Thr 
            100                 105                 110         


Leu Arg Asn Ser Gln Val Leu Asp Glu Asp Asn Ile Leu Asn Glu Thr 
        115                 120                 125             


Pro Lys Ser Pro Val Ile Asn Leu Pro His Glu Thr Thr Gly Ala Ser 
    130                 135                 140                 


Gln Leu Glu Gly Ser Thr Glu Ile Ala Lys Thr Gln Met Thr Pro Thr 
145                 150                 155                 160 


Asn Ser Val Ser Phe Leu Gly Glu Asn Arg Asp Cys Asn Lys Gln Gln 
                165                 170                 175     


Pro Ile Leu Ala Glu Arg Lys Arg Ile Leu Pro Thr Trp Met Leu Ala 
            180                 185                 190         


Glu His Leu Ser Asp Gln Asn Leu Ser Val Pro Ala Ile Ser Gly Gly 
        195                 200                 205             


Asn Val Ile Gln Gly Ser Gly Lys Glu Glu Ile Cys Lys Asp Lys Ser 
    210                 215                 220                 


Gln Leu Asn Thr Thr Gln Gln Gly Arg Arg Gln Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Ser Ser Glu Asn Thr Ser Ala Glu Gln Asp Thr Gly Glu Glu Cys Lys 
                245                 250                 255     


Asn Thr Asp Gln Glu Glu Ser Thr Ile Ser Ser Lys Glu Met Pro Gln 
            260                 265                 270         


Ser Phe Ser Ala Ile Thr Leu Ser Asn Thr Glu Met Asn Asn Ile Lys 
        275                 280                 285             


Thr Asn Ala Gln Arg Asn Lys Leu Pro Ile Glu Glu Leu Gly Lys Val 
    290                 295                 300                 


Ser Lys His Lys Ile Ala Thr Lys Arg Thr Pro His Lys Glu Asp Glu 
305                 310                 315                 320 


Ala Met Ser Cys Ser Glu Asn Cys Ser Ser Ala Gln Gly Asp Ser Leu 
                325                 330                 335     


Gln Asp Glu Ser Gln Gly Ser His Ser Glu Ser Ser Ser Asn Pro Ser 
            340                 345                 350         


Asn Pro Glu Thr Leu His Ala Lys Ala Thr Asp Ser Val Leu Gln Gly 
        355                 360                 365             


Ser Glu Gly Asn Lys Val Lys Arg Thr Ser Cys Met Tyr Gly Ala Asn 
    370                 375                 380                 


Cys Tyr Arg Lys Asn Pro Val His Phe Gln His Phe Ser His Pro Gly 
385                 390                 395                 400 


Asp Ser Asp Tyr Gly Gly Val Gln Ile Val Gly Gln Asp Glu Thr Asp 
                405                 410                 415     


Asp Arg Pro Glu Cys Pro Tyr Gly Pro Ser Cys Tyr Arg Lys Asn Pro 
            420                 425                 430         


Gln His Lys Ile Glu Tyr Arg His Asn Thr Leu Pro Val Arg Asn Val 
        435                 440                 445             


Leu Asp Glu Asp Asn Asp Asn Val Gly Gln Pro Asn Glu Tyr Asp Leu 
    450                 455                 460                 


Asn Asp Ser Phe Leu Asp Asp Glu Glu Glu Asp Tyr Glu Pro Thr Asp 
465                 470                 475                 480 


Glu Asp Ser Asp Trp Glu Pro Gly Lys Glu Asp Glu Glu Lys Glu Asp 
                485                 490                 495     


Val Glu Glu Leu Leu Lys Glu Ala Lys Arg Phe Met Lys Arg Lys 
            500                 505                 510     


<210> 5235
<211> 327
<212> PRT
<213> Homo sapiens

<400> 5235
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210> 5236
<211> 857
<212> PRT
<213> Homo sapiens

<400> 5236
Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Gly Asn Val Thr Ser Ala Ser 
        435                 440                 445             


Gly Ser Gln Met Ala Ser Gly Ile Ser Leu Val Ser Phe Asn Ser Arg 
    450                 455                 460                 


Pro Asp Gly Met His Gln Arg Ser Tyr Ser Val Ser Ser Ala Asp Gln 
465                 470                 475                 480 


Trp Ser Glu Ala Thr Val Ile Ala Asn Ser Ala Ile Ser Ser Asp Thr 
                485                 490                 495     


Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr 
            500                 505                 510         


Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys 
        515                 520                 525             


His Arg Arg Lys Lys Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser 
    530                 535                 540                 


Gly Thr Ala Glu Glu Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser 
545                 550                 555                 560 


Leu Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg 
                565                 570                 575     


Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln 
            580                 585                 590         


Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu 
        595                 600                 605             


Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys 
    610                 615                 620                 


Val Asp Cys Glu Thr Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly 
625                 630                 635                 640 


Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr 
                645                 650                 655     


His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu 
            660                 665                 670         


Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val 
        675                 680                 685             


Trp Glu Glu Ser Ser Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr 
    690                 695                 700                 


Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu 
705                 710                 715                 720 


Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu 
                725                 730                 735     


Leu Arg Ala Thr Ala Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu 
            740                 745                 750         


Ala His Gly Ser Arg Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp 
        755                 760                 765             


Gly Arg Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu 
    770                 775                 780                 


Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala 
785                 790                 795                 800 


His Gly Asn Thr Ala Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu 
                805                 810                 815     


Cys Ile Asp Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val 
            820                 825                 830         


Leu Met Ala Thr Pro Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn 
        835                 840                 845             


Ser Ser Gly Arg Val Pro Thr Ile Ile 
    850                 855         


<210> 5237
<211> 550
<212> PRT
<213> Homo sapiens

<400> 5237
Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Gly Ser Gln Glu Ser Ser Leu Arg 
        35                  40                  45              


Lys Thr Asp Ser Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile 
    50                  55                  60                  


Ser Arg Ser Pro Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser 
65                  70                  75                  80  


Arg Asn Thr Ser Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr 
                85                  90                  95      


Pro Ser Thr Ser Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser 
            100                 105                 110         


Gly Gln Pro Ser Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser 
        115                 120                 125             


Leu Asp Ser Arg Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg 
    130                 135                 140                 


Arg Ser Thr Lys Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile 
145                 150                 155                 160 


Val Arg Glu Ile Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser 
                165                 170                 175     


Arg Thr Ser Pro Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile 
            180                 185                 190         


Tyr Pro Ala Ser Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln 
        195                 200                 205             


Gln Gln Gln Arg Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala 
    210                 215                 220                 


Ser Met Arg Ser Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala 
                245                 250                 255     


Leu Phe Asn Met Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu 
            260                 265                 270         


Glu Lys Tyr Met Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr 
        275                 280                 285             


Pro Gly Pro Ala Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala 
    290                 295                 300                 


Arg Leu Arg Asp Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val 
305                 310                 315                 320 


Leu Met Thr Asn Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser 
                325                 330                 335     


Val Asn His Tyr Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly 
            340                 345                 350         


Lys Asp Pro Ile Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile 
        355                 360                 365             


Ala Ala Asp Ser Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala 
    370                 375                 380                 


Ser Ala Thr Met Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr 
385                 390                 395                 400 


Gln Leu Arg Val Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu 
                405                 410                 415     


Ser Glu His Phe Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr 
            420                 425                 430         


Asp Thr Leu Cys Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly 
        435                 440                 445             


Phe Leu Glu Asp Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn 
    450                 455                 460                 


Glu Arg Leu Leu Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser 
465                 470                 475                 480 


Ala Ala Ser Ser Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly 
                485                 490                 495     


Leu Glu Ile Asp Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro 
            500                 505                 510         


Ile Leu Val Lys Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe 
        515                 520                 525             


His Ile Glu Gly Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe 
    530                 535                 540                 


Asn Lys Lys Phe Ser Ser 
545                 550 


<210> 5238
<211> 295
<212> PRT
<213> Homo sapiens

<400> 5238
Met Pro Val His Thr Leu Ser Pro Gly Ala Pro Ser Ala Pro Ala Leu 
1               5                   10                  15      


Pro Cys Arg Leu Arg Thr Arg Val Pro Gly Tyr Leu Leu Arg Gly Pro 
            20                  25                  30          


Ala Asp Gly Gly Ala Arg Lys Pro Ser Ala Val Glu Arg Leu Glu Ala 
        35                  40                  45              


Asp Lys Ala Lys Tyr Val Lys Ser Leu His Val Ala Asn Thr Arg Gln 
    50                  55                  60                  


Glu Pro Val Gln Pro Leu Leu Ser Lys Gln Pro Leu Phe Ser Pro Glu 
65                  70                  75                  80  


Thr Arg Arg Thr Val Leu Thr Pro Ser Arg Arg Ala Leu Pro Gly Pro 
                85                  90                  95      


Cys Arg Arg Pro Gln Leu Asp Leu Asp Ile Leu Ser Ser Leu Ile Asp 
            100                 105                 110         


Leu Cys Asp Ser Pro Val Ser Pro Ala Glu Ala Ser Arg Thr Pro Gly 
        115                 120                 125             


Arg Ala Glu Gly Ala Gly Arg Pro Pro Pro Ala Thr Pro Pro Arg Pro 
    130                 135                 140                 


Pro Pro Ser Thr Ser Ala Val Arg Arg Val Asp Val Arg Pro Leu Pro 
145                 150                 155                 160 


Ala Ser Pro Ala Arg Pro Cys Pro Ser Pro Gly Pro Ala Ala Ala Ser 
                165                 170                 175     


Ser Pro Ala Arg Pro Pro Gly Leu Gln Arg Ser Lys Ser Asp Leu Ser 
            180                 185                 190         


Glu Arg Phe Ser Arg Ala Ala Ala Asp Leu Glu Arg Phe Phe Asn Phe 
        195                 200                 205             


Cys Gly Leu Asp Pro Glu Glu Ala Arg Gly Leu Gly Val Ala His Leu 
    210                 215                 220                 


Ala Arg Ala Ser Ser Asp Ile Val Ser Leu Ala Gly Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Gly Ser Ser Glu Gly Gly Cys Ser Arg Arg Ser Ser Val Thr Val 
                245                 250                 255     


Glu Glu Arg Ala Arg Glu Arg Val Pro Tyr Gly Val Ser Val Val Glu 
            260                 265                 270         


Arg Asn Ala Arg Val Ile Lys Trp Leu Tyr Gly Leu Arg Gln Ala Arg 
        275                 280                 285             


Glu Ser Pro Ala Ala Glu Gly 
    290                 295 


<210> 5239
<211> 182
<212> PRT
<213> Homo sapiens

<400> 5239
Met Ser Gly Arg Ser Val Pro His Ala His Pro Ala Thr Ala Glu Tyr 
1               5                   10                  15      


Glu Phe Ala Asn Pro Ser Arg Leu Gly Glu Gln Arg Phe Gly Glu Gly 
            20                  25                  30          


Leu Leu Pro Glu Glu Ile Leu Thr Pro Thr Leu Tyr His Gly Tyr Tyr 
        35                  40                  45              


Val Arg Pro Arg Ala Ala Pro Ala Gly Glu Gly Ser Arg Ala Gly Ala 
    50                  55                  60                  


Ser Glu Leu Arg Leu Ser Glu Gly Lys Phe Gln Ala Phe Leu Asp Val 
65                  70                  75                  80  


Ser His Phe Thr Pro Asp Glu Val Thr Val Arg Thr Val Asp Asn Leu 
                85                  90                  95      


Leu Glu Val Ser Ala Arg His Pro Gln Arg Leu Asp Arg His Gly Phe 
            100                 105                 110         


Val Ser Arg Glu Phe Cys Arg Thr Tyr Val Leu Pro Ala Asp Val Asp 
        115                 120                 125             


Pro Trp Arg Val Arg Ala Ala Leu Ser His Asp Gly Ile Leu Asn Leu 
    130                 135                 140                 


Glu Ala Pro Arg Gly Gly Arg His Leu Asp Thr Glu Val Asn Glu Val 
145                 150                 155                 160 


Tyr Ile Ser Leu Leu Pro Ala Pro Pro Asp Pro Glu Glu Glu Glu Glu 
                165                 170                 175     


Ala Ala Ile Val Glu Pro 
            180         


<210> 5240
<211> 211
<212> PRT
<213> Homo sapiens

<400> 5240
Met Ser Thr Ala Ala Val Pro Glu Leu Lys Gln Ile Ser Arg Val Glu 
1               5                   10                  15      


Ala Met Arg Leu Gly Pro Gly Trp Ser His Ser Cys His Ala Met Leu 
            20                  25                  30          


Tyr Ala Ala Asn Pro Gly Gln Leu Phe Gly Arg Ile Pro Met Arg Phe 
        35                  40                  45              


Ser Val Leu Met Gln Met Arg Phe Asp Gly Leu Leu Gly Phe Pro Gly 
    50                  55                  60                  


Gly Phe Val Asp Arg Arg Phe Trp Ser Leu Glu Asp Gly Leu Asn Arg 
65                  70                  75                  80  


Val Leu Gly Leu Gly Leu Gly Cys Leu Arg Leu Thr Glu Ala Asp Tyr 
                85                  90                  95      


Leu Ser Ser His Leu Thr Glu Gly Pro His Arg Val Val Ala His Leu 
            100                 105                 110         


Tyr Ala Arg Gln Leu Thr Leu Glu Gln Leu His Ala Val Glu Ile Ser 
        115                 120                 125             


Ala Val His Ser Arg Asp His Gly Leu Glu Val Leu Gly Leu Val Arg 
    130                 135                 140                 


Val Pro Leu Tyr Thr Gln Lys Asp Arg Val Gly Gly Phe Pro Asn Phe 
145                 150                 155                 160 


Leu Ser Asn Ala Phe Val Ser Thr Ala Lys Cys Gln Leu Leu Phe Ala 
                165                 170                 175     


Leu Lys Val Leu Asn Met Met Pro Glu Glu Lys Leu Val Glu Ala Leu 
            180                 185                 190         


Ala Ala Ala Thr Glu Lys Gln Lys Lys Ala Leu Glu Lys Leu Leu Pro 
        195                 200                 205             


Ala Ser Ser 
    210     


<210> 5241
<211> 873
<212> PRT
<213> Homo sapiens

<400> 5241
Met His Pro Pro Pro Pro Ala Ala Ala Met Asp Phe Ser Gln Asn Ser 
1               5                   10                  15      


Leu Phe Gly Tyr Met Glu Asp Leu Gln Glu Leu Thr Ile Ile Glu Arg 
            20                  25                  30          


Pro Val Arg Arg Ser Leu Lys Thr Pro Glu Glu Ile Glu Arg Leu Thr 
        35                  40                  45              


Val Asp Glu Asp Leu Ser Asp Ile Glu Arg Ala Val Tyr Leu Leu Ser 
    50                  55                  60                  


Ala Gly Gln Asp Val Gln Gly Thr Ser Val Ile Ala Asn Leu Pro Phe 
65                  70                  75                  80  


Leu Met Arg Gln Asn Pro Thr Glu Thr Leu Arg Arg Val Leu Pro Lys 
                85                  90                  95      


Val Arg Glu Ala Leu His Val Ala Gly Val Glu Met Gln Leu Thr Ala 
            100                 105                 110         


Ala Met Ser Phe Leu Thr Ile Leu Gln Asp Glu Ser Val Ser Ile His 
        115                 120                 125             


Ala Tyr Thr His Ser Phe Leu Gln Val Ile Leu Leu His Leu Glu His 
    130                 135                 140                 


Arg Asp Thr Gly Val Ser Asn Ala Trp Leu Glu Thr Leu Leu Ser Val 
145                 150                 155                 160 


Ile Glu Val Leu Pro Lys Glu Thr Leu Arg His Glu Ile Leu Asn Pro 
                165                 170                 175     


Leu Val Ser Lys Ala Gln Leu Ser Gln Thr Val Gln Ser Arg Leu Val 
            180                 185                 190         


Ser Cys Lys Ile Leu Gly Lys Leu Thr Asn Lys Phe Asp Ala His Thr 
        195                 200                 205             


Ile Lys Arg Glu Ile Leu Pro Leu Val Lys Ser Leu Cys Gln Asp Val 
    210                 215                 220                 


Glu Tyr Glu Val Arg Ser Cys Met Cys Arg Gln Leu Glu Asn Ile Ala 
225                 230                 235                 240 


Gln Gly Ile Gly Thr Glu Leu Thr Lys Ser Val Val Leu Pro Glu Leu 
                245                 250                 255     


Ile Glu Leu Ser Arg Asp Glu Gly Ser Ser Val Arg Leu Ala Ala Phe 
            260                 265                 270         


Glu Thr Leu Val Asn Leu Leu Asp Ile Phe Asp Thr Asp Asp Arg Ser 
        275                 280                 285             


Gln Thr Ile Leu Pro Leu Val Lys Ser Phe Cys Glu Lys Ser Phe Lys 
    290                 295                 300                 


Ala Asp Glu Ser Ile Leu Ile Ser Leu Ser Phe His Leu Gly Lys Leu 
305                 310                 315                 320 


Cys His Gly Leu Tyr Gly Ile Phe Thr Pro Asp Gln His Leu Arg Phe 
                325                 330                 335     


Leu Glu Phe Tyr Lys Lys Leu Cys Thr Leu Gly Leu Gln Gln Glu Asn 
            340                 345                 350         


Gly His Asn Glu Asn Gln Ile Pro Pro Gln Ile Leu Glu Gln Glu Lys 
        355                 360                 365             


Lys Tyr Ile Ser Val Arg Lys Asn Cys Ala Tyr Asn Phe Pro Ala Met 
    370                 375                 380                 


Ile Val Phe Val Asp Pro Lys Asn Phe His Met Glu Leu Tyr Ser Thr 
385                 390                 395                 400 


Phe Phe Cys Leu Cys His Asp Pro Glu Val Pro Val Arg Tyr Thr Ile 
                405                 410                 415     


Ala Ile Cys Phe Tyr Glu Val Ser Lys Leu Leu Asn Ser Gly Val Tyr 
            420                 425                 430         


Leu Ile His Lys Glu Leu Ile Thr Leu Leu Gln Asp Glu Ser Leu Glu 
        435                 440                 445             


Val Leu Asp Ala Leu Ile Asp His Leu Pro Glu Ile Leu Glu Leu Met 
    450                 455                 460                 


Ser Thr Gly Gly Glu Ser Ser Val Gln Glu Asn Lys Leu Ser Ser Leu 
465                 470                 475                 480 


Pro Asp Leu Ile Pro Ala Leu Thr Ala Ala Glu Gln Arg Ala Ala Ala 
                485                 490                 495     


Ser Leu Lys Trp Arg Thr His Glu Lys Leu Leu Gln Lys Tyr Ala Cys 
            500                 505                 510         


Leu Pro His Val Ile Ser Ser Asp Gln Ile Tyr Tyr Arg Phe Leu Gln 
        515                 520                 525             


Arg Met Phe Thr Ile Met Met Thr Asn Asn Val Leu Pro Val Gln Lys 
    530                 535                 540                 


Ala Ala Ser Arg Thr Leu Cys Ile Phe Leu Arg Tyr Asn Arg Lys Gln 
545                 550                 555                 560 


Glu Gln Arg His Glu Val Ile Gln Lys Leu Ile Glu Gln Leu Gly Gln 
                565                 570                 575     


Gly Lys Ser Tyr Trp Asn Arg Leu Arg Phe Leu Asp Thr Cys Glu Phe 
            580                 585                 590         


Ile Ile Glu Ile Phe Ser Lys Ser Phe Phe Cys Lys Tyr Phe Phe Leu 
        595                 600                 605             


Pro Ala Ile Glu Leu Thr His Asp Pro Val Ala Asn Val Arg Met Lys 
    610                 615                 620                 


Leu Cys Tyr Leu Leu Pro Lys Val Lys Ser Thr Leu Lys Ile Pro Ala 
625                 630                 635                 640 


Asp Lys His Leu Leu Gln Gln Leu Glu Met Cys Val Arg Lys Leu Leu 
                645                 650                 655     


Cys Gln Glu Lys Asp Lys Asp Val Leu Ala Ile Val Lys Arg Thr Val 
            660                 665                 670         


Leu Glu Leu Asp Arg Met Glu Met Ser Met Asp Ala Phe Gln Lys Lys 
        675                 680                 685             


Phe Tyr Glu Lys Asp Leu Leu Asp Gln Glu Lys Glu Arg Glu Glu Leu 
    690                 695                 700                 


Leu Leu Leu Glu Met Glu Gln Leu Glu Lys Glu Lys Gln Gln Asn Asp 
705                 710                 715                 720 


Gly Arg Pro Met Ser Asp Lys Met Phe Glu Lys Lys Arg Arg Asp Thr 
                725                 730                 735     


Lys Thr Pro Thr Gln Ser Leu Pro Lys Asn Ile Pro Ile Ser Val Pro 
            740                 745                 750         


Gly Pro Ser Ser Val Thr Pro Ser Thr Ser Lys Glu Ile Lys Lys Ser 
        755                 760                 765             


Lys Leu Ile Arg Ser Gln Ser Phe Asn Asn Gln Ala Phe His Ala Lys 
    770                 775                 780                 


Tyr Gly Asn Leu Glu Lys Cys Ala Ser Lys Ser Ser Thr Thr Gly Tyr 
785                 790                 795                 800 


Thr Thr Ser Val Ser Gly Leu Gly Lys Thr Ser Val Leu Ser Leu Ala 
                805                 810                 815     


Asp Asp Ser Phe Arg Thr Arg Asn Ala Ser Ser Val Pro Ser Ser Phe 
            820                 825                 830         


Ser Pro Asn Thr Pro Leu Pro Ser Thr Ser Arg Gly Thr Gly Asn Ser 
        835                 840                 845             


Val Asp Pro Lys Ser Ser Gly Ser Lys Asp Thr Gln Pro Arg Lys Ala 
    850                 855                 860                 


Thr Leu Lys Ser Arg Lys Ser Asn Pro 
865                 870             


<210> 5242
<211> 316
<212> PRT
<213> Homo sapiens

<400> 5242
Met Arg Gln Pro Leu Ser Trp Gly Arg Trp Arg Ala Met Leu Ala Arg 
1               5                   10                  15      


Thr Tyr Gly Pro Gly Pro Ser Ala Gly Tyr Arg Trp Ala Ser Gly Ala 
            20                  25                  30          


Gln Gly Tyr Val Arg Asn Pro Pro Val Gly Ala Cys Asp Leu Gln Gly 
        35                  40                  45              


Glu Leu Asp Arg Phe Gly Gly Ile Ser Val Arg Leu Ala Arg Leu Asp 
    50                  55                  60                  


Ala Leu Asp Arg Leu Asp Ala Ala Ala Phe Gln Lys Gly Leu Gln Ala 
65                  70                  75                  80  


Ala Val Gln Gln Trp Arg Ser Glu Gly Arg Thr Ala Val Trp Leu His 
                85                  90                  95      


Ile Pro Ile Leu Gln Ser Arg Phe Ile Ala Pro Ala Ala Ser Leu Gly 
            100                 105                 110         


Phe Cys Phe His His Ala Glu Ser Asp Ser Ser Thr Leu Thr Leu Trp 
        115                 120                 125             


Leu Arg Glu Gly Pro Ser Arg Leu Pro Gly Tyr Ala Ser His Gln Val 
    130                 135                 140                 


Gly Val Ala Gly Ala Val Phe Asp Glu Ser Thr Arg Lys Ile Leu Val 
145                 150                 155                 160 


Val Gln Asp Arg Asn Lys Leu Lys Asn Met Trp Lys Phe Pro Gly Gly 
                165                 170                 175     


Leu Ser Glu Pro Glu Glu Asp Ile Gly Asp Thr Ala Val Arg Glu Val 
            180                 185                 190         


Phe Glu Glu Thr Gly Ile Lys Ser Glu Phe Arg Ser Val Leu Ser Ile 
        195                 200                 205             


Arg Gln Gln His Thr Asn Pro Gly Ala Phe Gly Lys Ser Asp Met Tyr 
    210                 215                 220                 


Ile Ile Cys Arg Leu Lys Pro Tyr Ser Phe Thr Ile Asn Phe Cys Gln 
225                 230                 235                 240 


Glu Glu Cys Leu Arg Cys Glu Trp Met Asp Leu Asn Asp Leu Ala Lys 
                245                 250                 255     


Thr Glu Asn Thr Thr Pro Ile Thr Ser Arg Val Ala Arg Leu Leu Leu 
            260                 265                 270         


Tyr Gly Tyr Arg Glu Gly Phe Asp Lys Ile Asp Leu Thr Val Glu Glu 
        275                 280                 285             


Leu Pro Ala Val Tyr Thr Gly Leu Phe Tyr Lys Leu Tyr His Lys Glu 
    290                 295                 300                 


Leu Pro Glu Asn Tyr Lys Thr Met Lys Gly Ile Asp 
305                 310                 315     


<210> 5243
<211> 178
<212> PRT
<213> Homo sapiens

<400> 5243
Met Gly Glu Thr Trp Lys Asn Ile Cys Ser Thr Val Arg His Gly Trp 
1               5                   10                  15      


Trp Leu Arg Asp His Arg Met Ala Gly Leu Pro Ile Pro Pro Glu Ile 
            20                  25                  30          


Val Lys Glu Ala Glu Val Pro Gln Ala Ala Leu Gly Val Pro Ala Gln 
        35                  40                  45              


Gly Thr Gly Asp Asn Gly His Thr Pro Val Glu Glu Glu Val Gly Gly 
    50                  55                  60                  


Ile Pro Val Pro Ala Pro Gly Leu Leu Gln Val Thr Glu Arg Arg Gln 
65                  70                  75                  80  


Pro Leu Ser Ser Val Ser Ser Leu Glu Val His Phe Asp Leu Leu Asp 
                85                  90                  95      


Leu Thr Glu Leu Thr Asp Met Ser Asp Gln Glu Leu Ala Glu Val Phe 
            100                 105                 110         


Ala Asp Ser Asp Asp Glu Asn Leu Asn Thr Glu Ser Pro Ala Gly Leu 
        115                 120                 125             


His Pro Leu Pro Arg Ala Gly Tyr Leu Arg Ser Pro Ser Trp Thr Arg 
    130                 135                 140                 


Thr Arg Ala Glu Gln Ser His Glu Lys Gln Pro Leu Gly Asp Pro Glu 
145                 150                 155                 160 


Arg Gln Ala Thr Val Leu Asp Thr Phe Leu Thr Val Glu Arg Pro Gln 
                165                 170                 175     


Glu Asp 
        


<210> 5244
<211> 246
<212> PRT
<213> Homo sapiens

<400> 5244
Met Ala Glu Gln Glu Gln Arg Lys Ile Pro Leu Val Pro Glu Asn Leu 
1               5                   10                  15      


Leu Lys Lys Arg Lys Ala Tyr Gln Ala Leu Lys Ala Thr Gln Ala Lys 
            20                  25                  30          


Gln Ala Leu Leu Ala Lys Lys Glu Gln Lys Lys Gly Lys Gly Leu Arg 
        35                  40                  45              


Phe Lys Arg Leu Glu Ser Phe Leu His Asp Ser Trp Arg Gln Lys Arg 
    50                  55                  60                  


Asp Lys Val Arg Leu Arg Arg Leu Glu Val Lys Pro His Ala Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Lys His Ser Leu Ala Phe Val Val Arg Ile Glu Arg Ile 
                85                  90                  95      


Asp Gly Val Ser Leu Leu Val Gln Arg Thr Ile Ala Arg Leu Arg Leu 
            100                 105                 110         


Lys Lys Ile Phe Ser Gly Val Phe Val Lys Val Thr Pro Gln Asn Leu 
        115                 120                 125             


Lys Met Leu Arg Ile Val Glu Pro Tyr Val Thr Trp Gly Phe Pro Asn 
    130                 135                 140                 


Leu Lys Ser Val Arg Glu Leu Ile Leu Lys Arg Gly Gln Ala Lys Val 
145                 150                 155                 160 


Lys Asn Lys Thr Ile Pro Leu Thr Asp Asn Thr Val Ile Glu Glu His 
                165                 170                 175     


Leu Gly Lys Phe Gly Val Ile Cys Leu Glu Asp Leu Ile His Glu Ile 
            180                 185                 190         


Ala Phe Pro Gly Lys His Phe Gln Glu Ile Ser Trp Phe Leu Cys Pro 
        195                 200                 205             


Phe His Leu Ser Val Ala Arg His Ala Thr Lys Asn Arg Val Gly Phe 
    210                 215                 220                 


Leu Lys Glu Met Gly Thr Pro Gly Tyr Arg Gly Glu Arg Ile Asn Gln 
225                 230                 235                 240 


Leu Ile Arg Gln Leu Asn 
                245     


<210> 5245
<211> 813
<212> PRT
<213> Homo sapiens

<400> 5245
Met Ala Trp Pro Cys Ile Thr Arg Ala Cys Cys Ile Ala Arg Phe Trp 
1               5                   10                  15      


Asn Gln Leu Asp Lys Ala Asp Ile Ala Val Pro Leu Val Phe Thr Lys 
            20                  25                  30          


Tyr Ser Glu Ala Thr Glu His Pro Gly Ala Pro Pro Gln Pro Pro Pro 
        35                  40                  45              


Pro Gln Gln Gln Ala Gln Pro Ala Leu Ala Pro Pro Ser Ala Arg Ala 
    50                  55                  60                  


Val Ala Ile Glu Thr Gln Pro Ala Gln Gly Glu Leu Asp Ala Val Ala 
65                  70                  75                  80  


Arg Ala Thr Gly Pro Ala Pro Gly Pro Thr Gly Glu Arg Glu Pro Ala 
                85                  90                  95      


Ala Gly Pro Gly Arg Ser Gly Pro Gly Pro Gly Leu Gly Ser Gly Ser 
            100                 105                 110         


Thr Ser Gly Pro Ala Asp Ser Val Met Arg Gln Asp Tyr Arg Ala Trp 
        115                 120                 125             


Lys Val Gln Arg Pro Glu Pro Ser Cys Arg Pro Arg Ser Glu Tyr Gln 
    130                 135                 140                 


Pro Ser Asp Ala Pro Phe Glu Arg Glu Thr Gln Tyr Gln Lys Asp Phe 
145                 150                 155                 160 


Arg Ala Trp Pro Leu Pro Arg Arg Gly Asp His Pro Trp Ile Pro Lys 
                165                 170                 175     


Pro Val Gln Ile Ser Ala Ala Ser Gln Ala Ser Ala Pro Ile Leu Gly 
            180                 185                 190         


Ala Pro Lys Arg Arg Pro Gln Ser Gln Glu Arg Trp Pro Val Gln Ala 
        195                 200                 205             


Ala Ala Glu Ala Arg Glu Gln Glu Ala Ala Pro Gly Gly Ala Gly Gly 
    210                 215                 220                 


Leu Ala Ala Gly Lys Ala Ser Gly Ala Asp Glu Arg Asp Thr Arg Arg 
225                 230                 235                 240 


Lys Ala Gly Pro Ala Trp Ile Val Arg Arg Ala Glu Gly Leu Gly His 
                245                 250                 255     


Glu Gln Thr Pro Leu Pro Ala Ala Gln Ala Gln Val Gln Ala Thr Gly 
            260                 265                 270         


Pro Glu Ala Gly Arg Gly Arg Ala Ala Ala Asp Ala Leu Asn Arg Gln 
        275                 280                 285             


Ile Arg Glu Glu Val Ala Ser Ala Val Ser Ser Ser Tyr Arg Asn Glu 
    290                 295                 300                 


Phe Arg Ala Trp Thr Asp Ile Lys Pro Val Lys Pro Ile Lys Ala Lys 
305                 310                 315                 320 


Pro Gln Tyr Lys Pro Pro Asp Asp Lys Met Val His Glu Thr Ser Tyr 
                325                 330                 335     


Ser Ala Gln Phe Lys Gly Glu Ala Ser Lys Pro Thr Thr Ala Asp Asn 
            340                 345                 350         


Lys Val Ile Asp Arg Arg Arg Ile Arg Ser Leu Tyr Ser Glu Pro Phe 
        355                 360                 365             


Lys Glu Pro Pro Lys Val Glu Lys Pro Ser Val Gln Ser Ser Lys Pro 
    370                 375                 380                 


Lys Lys Thr Ser Ala Ser His Lys Pro Thr Arg Lys Ala Lys Asp Lys 
385                 390                 395                 400 


Gln Ala Val Ser Gly Gln Ala Ala Lys Lys Lys Ser Ala Glu Gly Pro 
                405                 410                 415     


Ser Thr Thr Lys Pro Asp Asp Lys Glu Gln Ser Lys Glu Met Asn Asn 
            420                 425                 430         


Lys Leu Ala Glu Ala Lys Glu Ser Leu Ala Gln Pro Val Ser Asp Ser 
        435                 440                 445             


Ser Lys Thr Gln Gly Pro Val Ala Thr Glu Pro Asp Lys Asp Gln Gly 
    450                 455                 460                 


Ser Val Val Pro Gly Leu Leu Lys Gly Gln Gly Pro Met Val Gln Glu 
465                 470                 475                 480 


Pro Leu Lys Lys Gln Gly Ser Val Val Pro Gly Pro Pro Lys Asp Leu 
                485                 490                 495     


Gly Pro Met Ile Pro Leu Pro Val Lys Asp Gln Asp His Thr Val Pro 
            500                 505                 510         


Glu Pro Leu Lys Asn Glu Ser Pro Val Ile Ser Ala Pro Val Lys Asp 
        515                 520                 525             


Gln Gly Pro Ser Val Pro Val Pro Pro Lys Asn Gln Ser Pro Met Val 
    530                 535                 540                 


Pro Ala Lys Val Lys Asp Gln Gly Ser Val Val Pro Glu Ser Leu Lys 
545                 550                 555                 560 


Asp Gln Gly Pro Arg Ile Pro Glu Pro Val Lys Asn Gln Ala Pro Met 
                565                 570                 575     


Val Pro Ala Pro Val Lys Asp Glu Gly Pro Met Val Ser Ala Ser Val 
            580                 585                 590         


Lys Asp Gln Gly Pro Met Val Ser Ala Pro Val Lys Asp Gln Gly Pro 
        595                 600                 605             


Ile Val Pro Ala Pro Val Lys Gly Glu Gly Pro Ile Val Pro Ala Pro 
    610                 615                 620                 


Val Lys Asp Glu Gly Pro Met Val Ser Ala Pro Ile Lys Asp Gln Asp 
625                 630                 635                 640 


Pro Met Val Pro Glu His Pro Lys Asp Glu Ser Ala Met Ala Thr Ala 
                645                 650                 655     


Pro Ile Lys Asn Gln Gly Ser Met Val Ser Glu Pro Val Lys Asn Gln 
            660                 665                 670         


Gly Leu Val Val Ser Gly Pro Val Lys Asp Gln Asp Val Val Val Pro 
        675                 680                 685             


Glu His Ala Lys Val His Asp Ser Ala Val Val Ala Pro Val Lys Asn 
    690                 695                 700                 


Gln Gly Pro Val Val Pro Glu Ser Val Lys Asn Gln Asp Pro Ile Leu 
705                 710                 715                 720 


Pro Val Leu Val Lys Asp Gln Gly Pro Thr Val Leu Gln Pro Pro Lys 
                725                 730                 735     


Asn Gln Gly Arg Ile Val Pro Glu Pro Leu Lys Asn Gln Val Pro Ile 
            740                 745                 750         


Val Pro Val Pro Leu Lys Asp Gln Asp Pro Leu Val Pro Val Pro Ala 
        755                 760                 765             


Lys Asp Gln Gly Pro Ala Val Pro Glu Pro Leu Lys Thr Gln Gly Pro 
    770                 775                 780                 


Arg Asp Pro Gln Leu Pro Thr Val Ser Pro Leu Pro Arg Val Met Ile 
785                 790                 795                 800 


Pro Thr Ala Pro His Thr Glu Tyr Ile Glu Ser Ser Pro 
                805                 810             


<210> 5246
<211> 86
<212> PRT
<213> Homo sapiens

<400> 5246
Met Pro Gln Tyr Gln Thr Trp Glu Glu Phe Ser Arg Ala Ala Glu Lys 
1               5                   10                  15      


Leu Tyr Leu Ala Asp Pro Met Lys Ala Arg Val Val Leu Lys Tyr Arg 
            20                  25                  30          


His Ser Asp Gly Asn Leu Cys Val Lys Val Thr Asp Asp Leu Val Cys 
        35                  40                  45              


Leu Val Tyr Lys Thr Asp Gln Ala Gln Asp Val Lys Lys Ile Glu Lys 
    50                  55                  60                  


Phe His Ser Gln Leu Met Arg Leu Met Val Ala Lys Glu Ala Arg Asn 
65                  70                  75                  80  


Val Thr Met Glu Thr Glu 
                85      


<210> 5247
<211> 401
<212> PRT
<213> Homo sapiens

<400> 5247
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu Lys Phe Tyr Tyr 
                165                 170                 175     


Asn Pro Asn Phe Lys Arg Gly Tyr Pro Gln Leu Leu Val Arg Val Lys 
            180                 185                 190         


Arg Arg Ile Gly Val Lys Asn Ala Ser Pro Ile Ser Thr Leu Phe Asn 
        195                 200                 205             


Glu Asp Phe Asn Lys Lys His Phe Arg Ala Gly Ala Asn Met Glu Asn 
    210                 215                 220                 


His Asn Ser Ala Leu Ala Ala Glu Ala Ser Glu Glu Ser Leu Phe Ser 
225                 230                 235                 240 


Ala Ser Lys Asn Leu Asn Met Pro Leu Thr Arg Glu Ser Ser Val Arg 
                245                 250                 255     


Gln Ile Ile Ala Asn Ser Ser Val Pro Ile Arg Ser Gly Phe Pro Pro 
            260                 265                 270         


Pro Ser Pro Ser Thr Ser Val Gly Pro Ser Glu Gln Ile Ala Thr Asp 
        275                 280                 285             


Gln His Ala Ile Leu Asn Gln Leu Thr Thr Ile His Met His Ser His 
    290                 295                 300                 


Ser Thr Tyr Met Gln Ala Arg Gly His Ile Val Asn Phe Ile Thr Thr 
305                 310                 315                 320 


Thr Thr Ser Gln Tyr His Ile Ile Ser Pro Leu Gln Asn Gly Tyr Phe 
                325                 330                 335     


Gly Leu Thr Val Glu Pro Ser Ala Val Pro Thr Arg Tyr Pro Leu Val 
            340                 345                 350         


Ser Val Asn Glu Ala Pro Tyr Arg Asn Met Leu Pro Ala Gly Asn Pro 
        355                 360                 365             


Trp Leu Gln Met Pro Thr Ile Ala Asp Arg Ser Ala Ala Pro His Ser 
    370                 375                 380                 


Arg Leu Ala Leu Gln Pro Ser Pro Leu Asp Lys Tyr His Pro Asn Tyr 
385                 390                 395                 400 


Asn 
    


<210> 5248
<211> 1433
<212> PRT
<213> Homo sapiens

<400> 5248
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Cys Tyr Leu Arg Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His 
            820                 825                 830         


Val Arg Thr Arg Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu 
        835                 840                 845             


Leu Ser Val Phe Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala 
    850                 855                 860                 


Gln Trp Gln Arg Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn 
865                 870                 875                 880 


Tyr Met Thr Gln Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp 
                885                 890                 895     


Pro Leu Ser Glu Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly 
            900                 905                 910         


Val Lys Gly Val Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe 
        915                 920                 925             


Arg Pro Ala Ser Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser 
    930                 935                 940                 


Met Glu Asn Leu Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala 
945                 950                 955                 960 


Leu Gln Thr Ser Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg 
                965                 970                 975     


Ser Pro Leu Ile Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser 
            980                 985                 990         


Glu Thr Ser Ser Ser Arg Pro Gly  Gly Tyr Arg Leu Phe  Ser Ser Ser 
        995                 1000                 1005             


Arg Pro  Pro Thr Glu Met Lys  Gln Ser Gly Leu Gly  Ser Gln Cys 
    1010                 1015                 1020             


Thr Gly  Leu Phe Ser Thr Thr  Val Leu Gly Gly Ser  Ser Ser Ala 
    1025                 1030                 1035             


Pro Asn  Leu Gln Asp Tyr Ala  Arg Ser His Gly Lys  Lys Leu Pro 
    1040                 1045                 1050             


Pro Ala  Ser Leu Lys His Arg  Asp Glu Leu Leu Phe  Val Pro Ala 
    1055                 1060                 1065             


Val Lys  Arg Phe Ser Val Ser  Phe Ala Lys His Pro  Thr Asn Gly 
    1070                 1075                 1080             


Phe Glu  Gly Cys Ser Met Val  Pro Thr Ile Tyr Pro  Leu Glu Thr 
    1085                 1090                 1095             


Leu His  Asn Ala Leu Ser Leu  Arg Gln Val Ser Glu  Phe Leu Ser 
    1100                 1105                 1110             


Arg Val  Cys Gln Arg His Thr  Asp Ala Gln Ala Gln  Ala Ser Ala 
    1115                 1120                 1125             


Ala Leu  Phe Asp Ser Met His  Ser Ser Gln Ala Ser  Asp Asn Pro 
    1130                 1135                 1140             


Phe Ser  Pro Pro Arg Thr Leu  His Ser Pro Pro Leu  Gln Leu Gln 
    1145                 1150                 1155             


Gln Arg  Ser Glu Lys Pro Pro  Trp Tyr Ser Ser Gly  Pro Ser Ser 
    1160                 1165                 1170             


Thr Val  Ser Ser Ala Gly Pro  Ser Ser Pro Thr Thr  Val Asp Gly 
    1175                 1180                 1185             


Asn Ser  Gln Phe Gly Phe Ser  Asp Gln Pro Ser Leu  Asn Ser His 
    1190                 1195                 1200             


Val Ala  Glu Glu His Gln Gly  Leu Gly Leu Leu Gln  Glu Thr Pro 
    1205                 1210                 1215             


Gly Ser  Gly Ala Gln Glu Leu  Ser Ile Glu Gly Glu  Gln Glu Leu 
    1220                 1225                 1230             


Phe Glu  Pro Asn Gln Ser Pro  Gln Val Pro Pro Met  Glu Thr Ser 
    1235                 1240                 1245             


Gln Pro  Tyr Glu Glu Val Ser  Gln Pro Cys Gln Glu  Val Pro Asp 
    1250                 1255                 1260             


Ile Ser  Gln Pro Cys Gln Asp  Ile Ser Glu Ala Leu  Ser Gln Pro 
    1265                 1270                 1275             


Cys Gln  Lys Val Pro Asp Ile  Ser Gln Gln Cys Gln  Glu Asn His 
    1280                 1285                 1290             


Asp Asn  Gly Asn His Thr Cys  Gln Glu Val Pro His  Ile Ser Gln 
    1295                 1300                 1305             


Pro Cys  Gln Lys Ser Ser Gln  Leu Cys Gln Lys Val  Ser Glu Glu 
    1310                 1315                 1320             


Val Cys  Gln Leu Cys Leu Glu  Asn Ser Glu Glu Val  Ser Gln Pro 
    1325                 1330                 1335             


Cys Gln  Gly Val Ser Val Glu  Val Gly Lys Leu Val  His Lys Phe 
    1340                 1345                 1350             


His Val  Gly Val Gly Ser Leu  Val Gln Glu Thr Leu  Val Glu Val 
    1355                 1360                 1365             


Gly Ser  Pro Ala Glu Glu Ile  Pro Glu Glu Val Ile  Gln Pro Tyr 
    1370                 1375                 1380             


Gln Glu  Phe Ser Val Glu Val  Gly Arg Leu Ala Gln  Glu Thr Ser 
    1385                 1390                 1395             


Ala Ile  Asn Leu Leu Ser Gln  Gly Ile Pro Glu Ile  Asp Lys Pro 
    1400                 1405                 1410             


Ser Gln  Glu Phe Pro Glu Glu  Ile Asp Leu Gln Ala  Gln Glu Val 
    1415                 1420                 1425             


Pro Glu  Glu Ile Asn 
    1430             


<210> 5249
<211> 378
<212> PRT
<213> Homo sapiens

<400> 5249
Met Asp Ser Val Arg Ser Gly Ala Phe Gly His Leu Phe Arg Pro Asp 
1               5                   10                  15      


Asn Phe Ile Phe Gly Gln Ser Gly Ala Gly Asn Asn Trp Ala Lys Gly 
            20                  25                  30          


His Tyr Thr Glu Gly Ala Glu Leu Val Asp Ser Val Leu Asp Val Val 
        35                  40                  45              


Arg Lys Glu Cys Glu Asn Cys Asp Cys Leu Gln Gly Phe Gln Leu Thr 
    50                  55                  60                  


His Ser Leu Gly Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Ile 
65                  70                  75                  80  


Ser Lys Val Arg Glu Glu Tyr Pro Asp Arg Ile Met Asn Thr Phe Ser 
                85                  90                  95      


Val Val Pro Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn 
            100                 105                 110         


Ala Thr Leu Ser Ile His Gln Leu Val Glu Asn Thr Asp Glu Thr Tyr 
        115                 120                 125             


Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys 
    130                 135                 140                 


Leu Ala Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr 
145                 150                 155                 160 


Met Ser Gly Val Thr Thr Ser Leu Arg Phe Pro Gly Gln Leu Asn Ala 
                165                 170                 175     


Asp Leu Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His 
            180                 185                 190         


Phe Phe Met Pro Gly Phe Ala Pro Leu Thr Ala Arg Gly Ser Gln Gln 
        195                 200                 205             


Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr Gln Gln Met Phe Asp Ala 
    210                 215                 220                 


Lys Asn Met Met Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr 
225                 230                 235                 240 


Val Ala Thr Val Phe Arg Gly Arg Met Ser Met Lys Glu Val Asp Glu 
                245                 250                 255     


Gln Met Leu Ala Ile Gln Ser Lys Asn Ser Ser Tyr Phe Val Glu Trp 
            260                 265                 270         


Ile Pro Asn Asn Val Lys Val Ala Val Cys Asp Ile Pro Pro Arg Gly 
        275                 280                 285             


Leu Lys Met Ser Ser Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu 
    290                 295                 300                 


Leu Phe Lys Arg Ile Ser Glu Gln Phe Thr Ala Met Phe Arg Arg Lys 
305                 310                 315                 320 


Ala Phe Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met Glu Phe 
                325                 330                 335     


Thr Glu Ala Glu Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln 
            340                 345                 350         


Tyr Gln Asp Ala Thr Ala Glu Glu Glu Gly Glu Met Tyr Glu Asp Asp 
        355                 360                 365             


Glu Glu Glu Ser Glu Ala Gln Gly Pro Lys 
    370                 375             


<210> 5250
<211> 386
<212> PRT
<213> Homo sapiens

<400> 5250
Met Cys Glu Arg Ala Ala Arg Leu Cys Arg Ala Gly Ala His Arg Leu 
1               5                   10                  15      


Leu Arg Glu Pro Pro Gln Gln Gly Arg Ala Leu Gly Gly Leu Leu Arg 
            20                  25                  30          


Trp Val Gly Ala Arg Met Gly Glu Pro Arg Glu Ser Leu Ala Pro Ala 
        35                  40                  45              


Ala Pro Ala Asp Pro Gly Pro Ala Ser Pro Arg Gly Gly Thr Ala Val 
    50                  55                  60                  


Ile Leu Asp Ile Phe Arg Arg Ala Asp Lys Asn Asp Asp Gly Lys Leu 
65                  70                  75                  80  


Ser Leu Glu Glu Phe Gln Leu Phe Phe Ala Asp Gly Val Leu Asn Glu 
                85                  90                  95      


Lys Glu Leu Glu Asp Leu Phe His Thr Ile Asp Ser Asp Asn Thr Asn 
            100                 105                 110         


His Val Asp Thr Lys Glu Leu Cys Asp Tyr Phe Val Asp His Met Gly 
        115                 120                 125             


Asp Tyr Glu Asp Val Leu Ala Ser Leu Glu Thr Leu Asn His Ser Val 
    130                 135                 140                 


Leu Lys Ala Met Gly Tyr Thr Lys Lys Val Tyr Glu Gly Gly Ser Asn 
145                 150                 155                 160 


Val Asp Gln Phe Val Thr Arg Phe Leu Leu Lys Glu Thr Ala Asn Gln 
                165                 170                 175     


Ile Gln Ser Leu Leu Ser Ser Val Glu Ser Ala Val Glu Ala Ile Glu 
            180                 185                 190         


Glu Gln Thr Ser Gln Leu Arg Gln Asn His Ile Lys Pro Ser His Ser 
        195                 200                 205             


Ala Ala Gln Thr Trp Cys Gly Ser Pro Thr Pro Ala Ser Ala Pro Asn 
    210                 215                 220                 


His Lys Leu Met Ala Met Glu Gln Gly Lys Thr Leu Pro Ser Ala Thr 
225                 230                 235                 240 


Glu Asp Ala Lys Glu Glu Gly Leu Glu Ala Gln Ile Ser Arg Leu Ala 
                245                 250                 255     


Glu Leu Ile Gly Arg Leu Glu Ser Lys Ala Leu Trp Phe Asp Leu Gln 
            260                 265                 270         


Gln Arg Leu Ser Asp Glu Asp Gly Thr Asn Met His Leu Gln Leu Val 
        275                 280                 285             


Arg Gln Glu Met Ala Val Cys Pro Glu Gln Leu Ser Glu Phe Leu Asp 
    290                 295                 300                 


Ser Leu Arg Gln Tyr Leu Arg Gly Thr Thr Gly Val Arg Asn Cys Phe 
305                 310                 315                 320 


His Ile Thr Ala Val Arg Leu Ser Asp Gly Phe Thr Phe Val Ile Tyr 
                325                 330                 335     


Glu Phe Trp Glu Thr Glu Glu Ala Trp Lys Arg His Leu Gln Ser Pro 
            340                 345                 350         


Leu Cys Lys Ala Phe Arg His Val Lys Val Asp Thr Leu Ser Gln Pro 
        355                 360                 365             


Glu Ala Leu Ser Arg Ile Leu Val Pro Ala Ala Trp Cys Thr Val Gly 
    370                 375                 380                 


Arg Asp 
385     


<210> 5251
<211> 493
<212> PRT
<213> Homo sapiens

<400> 5251
Met Glu Arg Ser Pro Asp Val Ser Pro Gly Pro Ser Arg Ser Phe Lys 
1               5                   10                  15      


Glu Glu Leu Leu Cys Ala Val Cys Tyr Asp Pro Phe Arg Asp Ala Val 
            20                  25                  30          


Thr Leu Arg Cys Gly His Asn Phe Cys Arg Gly Cys Val Ser Arg Cys 
        35                  40                  45              


Trp Glu Val Gln Val Ser Pro Thr Cys Pro Val Cys Lys Asp Arg Ala 
    50                  55                  60                  


Ser Pro Ala Asp Leu Arg Thr Asn His Thr Leu Asn Asn Leu Val Glu 
65                  70                  75                  80  


Lys Leu Leu Arg Glu Glu Ala Glu Gly Ala Arg Trp Thr Ser Tyr Arg 
                85                  90                  95      


Phe Ser Arg Val Cys Arg Leu His Arg Gly Gln Leu Ser Leu Phe Cys 
            100                 105                 110         


Leu Glu Asp Lys Glu Leu Leu Cys Cys Ser Cys Gln Ala Asp Pro Arg 
        115                 120                 125             


His Gln Gly His Arg Val Gln Pro Val Lys Asp Thr Ala His Asp Phe 
    130                 135                 140                 


Arg Ala Lys Cys Arg Asn Met Glu His Ala Leu Arg Glu Lys Ala Lys 
145                 150                 155                 160 


Ala Phe Trp Ala Met Arg Arg Ser Tyr Glu Ala Ile Ala Lys His Asn 
                165                 170                 175     


Gln Val Glu Ala Ala Trp Leu Glu Gly Arg Ile Arg Gln Glu Phe Asp 
            180                 185                 190         


Lys Leu Arg Glu Phe Leu Arg Val Glu Glu Gln Ala Ile Leu Asp Ala 
        195                 200                 205             


Met Ala Glu Glu Thr Arg Gln Lys Gln Leu Leu Ala Asp Glu Lys Met 
    210                 215                 220                 


Lys Gln Leu Thr Glu Glu Thr Glu Val Leu Ala His Glu Ile Glu Arg 
225                 230                 235                 240 


Leu Gln Met Glu Met Lys Glu Asp Asp Val Ser Phe Leu Met Lys His 
                245                 250                 255     


Lys Ser Arg Lys Arg Arg Leu Phe Cys Thr Met Glu Pro Glu Pro Val 
            260                 265                 270         


Gln Pro Gly Met Leu Ile Asp Val Cys Lys Tyr Leu Gly Ser Leu Gln 
        275                 280                 285             


Tyr Arg Val Trp Lys Lys Met Leu Ala Ser Val Glu Ser Val Pro Phe 
    290                 295                 300                 


Ser Phe Asp Pro Asn Thr Ala Ala Gly Trp Leu Ser Val Ser Asp Asp 
305                 310                 315                 320 


Leu Thr Ser Val Thr Asn His Gly Tyr Arg Val Gln Val Glu Asn Pro 
                325                 330                 335     


Glu Arg Phe Ser Ser Ala Pro Cys Leu Leu Gly Ser Arg Val Phe Ser 
            340                 345                 350         


Gln Gly Ser His Ala Trp Glu Val Ala Leu Gly Gly Leu Gln Ser Trp 
        355                 360                 365             


Arg Val Gly Val Val Arg Val Arg Gln Asp Ser Gly Ala Glu Gly His 
    370                 375                 380                 


Ser His Ser Cys Tyr His Asp Thr Arg Ser Gly Phe Trp Tyr Val Cys 
385                 390                 395                 400 


Arg Thr Gln Gly Val Glu Gly Asp His Cys Val Thr Ser Asp Pro Ala 
                405                 410                 415     


Thr Ser Pro Leu Val Leu Ala Ile Pro Arg Arg Leu Arg Val Glu Leu 
            420                 425                 430         


Glu Cys Glu Glu Gly Glu Leu Ser Phe Tyr Asp Ala Glu Arg His Cys 
        435                 440                 445             


His Leu Tyr Thr Phe His Ala Arg Phe Gly Glu Val Arg Pro Tyr Phe 
    450                 455                 460                 


Tyr Leu Gly Gly Ala Arg Gly Ala Gly Pro Pro Glu Pro Leu Arg Ile 
465                 470                 475                 480 


Cys Pro Leu His Ile Ser Val Lys Glu Glu Leu Asp Gly 
                485                 490             


<210> 5252
<211> 753
<212> PRT
<213> Homo sapiens

<400> 5252
Met Ala Pro Asp Ser Asp Pro Phe Pro Glu Gly Pro Leu Leu Lys Leu 
1               5                   10                  15      


Leu Pro Leu Asp Ala Arg Asp Arg Gly Thr Gln Arg Cys Arg Leu Gly 
            20                  25                  30          


Pro Ala Ala Leu His Ala Leu Gly Ala Arg Leu Gly Ser Ala Val Lys 
        35                  40                  45              


Ile Ser Leu Pro Asp Gly Gly Ser Cys Leu Cys Thr Ala Trp Pro Arg 
    50                  55                  60                  


Arg Asp Gly Ala Asp Gly Phe Val Gln Leu Asp Pro Leu Cys Ala Ser 
65                  70                  75                  80  


Pro Gly Ala Ala Val Gly Ala Ser Arg Ser Arg Arg Ser Leu Ser Leu 
                85                  90                  95      


Asn Arg Leu Leu Leu Val Pro Cys Pro Pro Leu Arg Arg Val Ala Val 
            100                 105                 110         


Trp Pro Val Leu Arg Glu Arg Ala Gly Ala Pro Gly Ala Arg Asn Thr 
        115                 120                 125             


Ala Ala Val Leu Glu Ala Ala Gln Glu Leu Leu Arg Asn Arg Pro Ile 
    130                 135                 140                 


Ser Leu Gly His Val Val Val Ala Pro Pro Gly Ala Pro Gly Leu Val 
145                 150                 155                 160 


Ala Ala Leu His Ile Val Gly Gly Thr Pro Ser Pro Asp Pro Ala Gly 
                165                 170                 175     


Leu Val Thr Pro Arg Thr Arg Val Ser Leu Gly Gly Glu Pro Pro Ser 
            180                 185                 190         


Glu Ala Gln Pro Gln Pro Glu Val Pro Leu Gly Gly Leu Ser Glu Ala 
        195                 200                 205             


Ala Asp Ser Leu Arg Glu Leu Leu Arg Leu Pro Leu Arg Tyr Pro Arg 
    210                 215                 220                 


Ala Leu Thr Ala Leu Gly Leu Ala Val Pro Arg Gly Val Leu Leu Ala 
225                 230                 235                 240 


Gly Pro Pro Gly Val Gly Lys Thr Gln Leu Val Arg Ala Val Ala Arg 
                245                 250                 255     


Glu Ala Gly Ala Glu Leu Leu Ala Val Ser Ala Pro Ala Leu Gln Gly 
            260                 265                 270         


Ser Arg Pro Gly Glu Thr Glu Glu Asn Val Arg Arg Val Phe Gln Arg 
        275                 280                 285             


Ala Arg Glu Leu Ala Ser Arg Gly Pro Ser Leu Leu Phe Leu Asp Glu 
    290                 295                 300                 


Met Asp Ala Leu Cys Pro Gln Arg Gly Ser Arg Ala Pro Glu Ser Arg 
305                 310                 315                 320 


Val Val Ala Gln Val Leu Thr Leu Leu Asp Gly Ala Ser Gly Asp Arg 
                325                 330                 335     


Glu Val Val Val Val Gly Ala Thr Asn Arg Pro Asp Ala Leu Asp Pro 
            340                 345                 350         


Ala Leu Arg Arg Pro Gly Arg Phe Asp Arg Glu Val Val Ile Gly Thr 
        355                 360                 365             


Pro Thr Leu Lys Gln Arg Lys Glu Ile Leu Gln Val Ile Thr Ser Lys 
    370                 375                 380                 


Met Pro Ile Ser Ser His Val Asp Leu Gly Leu Leu Ala Glu Met Thr 
385                 390                 395                 400 


Val Gly Tyr Val Gly Ala Asp Leu Thr Ala Leu Cys Arg Glu Ala Ala 
                405                 410                 415     


Met His Ala Leu Leu His Ser Glu Lys Asn Gln Asp Asn Pro Val Ile 
            420                 425                 430         


Asp Glu Ile Asp Phe Leu Glu Ala Phe Lys Asn Ile Gln Pro Ser Ser 
        435                 440                 445             


Phe Arg Ser Val Ile Gly Leu Met Asp Ile Lys Pro Val Asp Trp Glu 
    450                 455                 460                 


Glu Ile Gly Gly Leu Glu Asp Val Lys Leu Lys Leu Lys Gln Ser Ile 
465                 470                 475                 480 


Glu Trp Pro Leu Lys Phe Pro Trp Glu Phe Val Arg Met Gly Leu Thr 
                485                 490                 495     


Gln Pro Lys Gly Val Leu Leu Tyr Gly Pro Pro Gly Cys Ala Lys Thr 
            500                 505                 510         


Thr Leu Val Arg Ala Leu Ala Thr Ser Cys His Cys Ser Phe Val Ser 
        515                 520                 525             


Val Ser Gly Ala Asp Leu Phe Ser Pro Phe Val Gly Asp Ser Glu Lys 
    530                 535                 540                 


Val Leu Ser Gln Ile Phe Arg Gln Ala Arg Ala Ser Thr Pro Ala Ile 
545                 550                 555                 560 


Leu Phe Leu Asp Glu Ile Asp Ser Ile Leu Gly Ala Arg Ser Ala Ser 
                565                 570                 575     


Lys Thr Gly Cys Asp Val Gln Glu Arg Val Leu Ser Val Leu Leu Asn 
            580                 585                 590         


Glu Leu Asp Gly Val Gly Leu Lys Thr Ile Glu Arg Arg Gly Ser Lys 
        595                 600                 605             


Ser Ser Gln Gln Glu Phe Gln Glu Val Phe Asn Arg Ser Val Met Ile 
    610                 615                 620                 


Ile Ala Ala Thr Asn Arg Pro Asp Val Leu Asp Thr Ala Leu Leu Arg 
625                 630                 635                 640 


Pro Gly Arg Leu Asp Lys Ile Ile Tyr Ile Pro Pro Pro Asp His Lys 
                645                 650                 655     


Gly Arg Leu Ser Ile Leu Lys Val Cys Thr Lys Thr Met Pro Ile Gly 
            660                 665                 670         


Pro Asp Val Ser Leu Glu Asn Leu Ala Ala Glu Thr Cys Phe Phe Ser 
        675                 680                 685             


Gly Ala Asp Leu Arg Asn Leu Cys Thr Glu Ala Ala Leu Leu Ala Leu 
    690                 695                 700                 


Gln Glu Asn Gly Leu Asp Ala Thr Thr Val Lys Gln Glu His Phe Leu 
705                 710                 715                 720 


Lys Ser Leu Lys Thr Val Lys Pro Ser Leu Ser Cys Lys Asp Leu Ala 
                725                 730                 735     


Leu Tyr Glu Asn Leu Phe Lys Lys Glu Gly Phe Ser Asn Val Glu Gly 
            740                 745                 750         


Ile 
    


<210> 5253
<211> 341
<212> PRT
<213> Homo sapiens

<400> 5253
Met Pro Lys Arg Lys Val Thr Phe Gln Gly Val Gly Asp Glu Glu Asp 
1               5                   10                  15      


Glu Asp Glu Ile Ile Val Pro Lys Lys Lys Leu Val Asp Pro Val Ala 
            20                  25                  30          


Gly Ser Gly Gly Pro Gly Ser Arg Phe Lys Gly Lys His Ser Leu Asp 
        35                  40                  45              


Ser Asp Glu Glu Glu Asp Asp Asp Asp Gly Gly Ser Ser Lys Tyr Asp 
    50                  55                  60                  


Ile Leu Ala Ser Glu Asp Val Glu Gly Gln Glu Ala Ala Thr Leu Pro 
65                  70                  75                  80  


Ser Glu Gly Gly Val Arg Ile Thr Pro Phe Asn Leu Gln Glu Glu Met 
                85                  90                  95      


Glu Glu Gly His Phe Asp Ala Asp Gly Asn Tyr Phe Leu Asn Arg Asp 
            100                 105                 110         


Ala Gln Ile Arg Asp Ser Trp Leu Asp Asn Ile Asp Trp Val Lys Ile 
        115                 120                 125             


Arg Glu Arg Pro Pro Gly Gln Arg Gln Ala Ser Asp Ser Glu Glu Glu 
    130                 135                 140                 


Asp Ser Leu Gly Gln Thr Ser Met Ser Ala Gln Ala Leu Leu Glu Gly 
145                 150                 155                 160 


Leu Leu Glu Leu Leu Leu Pro Arg Glu Thr Val Ala Gly Ala Leu Arg 
                165                 170                 175     


Arg Leu Gly Ala Arg Gly Gly Gly Lys Gly Arg Lys Gly Pro Gly Gln 
            180                 185                 190         


Pro Ser Ser Pro Gln Arg Leu Asp Arg Leu Ser Gly Leu Ala Asp Gln 
        195                 200                 205             


Met Val Ala Arg Gly Asn Leu Gly Val Tyr Gln Glu Thr Arg Glu Arg 
    210                 215                 220                 


Leu Ala Met Arg Leu Lys Gly Leu Gly Cys Gln Thr Leu Gly Pro His 
225                 230                 235                 240 


Asn Pro Thr Pro Pro Pro Ser Leu Asp Met Phe Ala Glu Glu Leu Ala 
                245                 250                 255     


Glu Glu Glu Leu Glu Thr Pro Thr Pro Thr Gln Arg Gly Glu Ala Glu 
            260                 265                 270         


Ser Arg Gly Asp Gly Leu Val Asp Val Met Trp Glu Tyr Lys Trp Glu 
        275                 280                 285             


Asn Thr Gly Asp Ala Glu Leu Tyr Gly Pro Phe Thr Ser Ala Gln Met 
    290                 295                 300                 


Gln Thr Trp Val Ser Glu Gly Tyr Phe Pro Asp Gly Val Tyr Cys Arg 
305                 310                 315                 320 


Lys Leu Asp Pro Pro Gly Gly Gln Phe Tyr Asn Ser Lys Arg Ile Asp 
                325                 330                 335     


Phe Asp Leu Tyr Thr 
            340     


<210> 5254
<211> 229
<212> PRT
<213> Homo sapiens

<400> 5254
Met Ala Glu Glu Met Glu Ser Ser Leu Glu Ala Ser Phe Ser Ser Ser 
1               5                   10                  15      


Gly Ala Val Ser Gly Ala Ser Gly Phe Leu Pro Pro Ala Arg Ser Arg 
            20                  25                  30          


Ile Phe Lys Ile Ile Val Ile Gly Asp Ser Asn Val Gly Lys Thr Cys 
        35                  40                  45              


Leu Thr Tyr Arg Phe Cys Ala Gly Arg Phe Pro Asp Arg Thr Glu Ala 
    50                  55                  60                  


Thr Ile Gly Val Asp Phe Arg Glu Arg Ala Val Glu Ile Asp Gly Glu 
65                  70                  75                  80  


Arg Ile Lys Ile Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg 
                85                  90                  95      


Lys Ser Met Val Gln His Tyr Tyr Arg Asn Val His Ala Val Val Phe 
            100                 105                 110         


Val Tyr Asp Met Thr Asn Met Ala Ser Phe His Ser Leu Pro Ser Trp 
        115                 120                 125             


Ile Glu Glu Cys Lys Gln His Leu Leu Ala Asn Asp Ile Pro Arg Ile 
    130                 135                 140                 


Leu Val Gly Asn Lys Cys Asp Leu Arg Ser Ala Ile Gln Val Pro Thr 
145                 150                 155                 160 


Asp Leu Ala Gln Lys Phe Ala Asp Thr His Ser Met Pro Leu Phe Glu 
                165                 170                 175     


Thr Ser Ala Lys Asn Pro Asn Asp Asn Asp His Val Glu Ala Ile Phe 
            180                 185                 190         


Met Thr Leu Ala His Lys Leu Lys Ser His Lys Pro Leu Met Leu Ser 
        195                 200                 205             


Gln Pro Pro Asp Asn Gly Ile Ile Leu Lys Pro Glu Pro Lys Pro Ala 
    210                 215                 220                 


Met Thr Cys Trp Cys 
225                 


<210> 5255
<211> 783
<212> PRT
<213> Homo sapiens

<400> 5255
Met Leu Leu Gly Phe Arg Arg Gly Arg Arg Ser His Phe Lys His Ile 
1               5                   10                  15      


Ile His Gly Leu Leu Pro Ala Ala Ser Val Ala Pro Lys Ala Ala Val 
            20                  25                  30          


Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser Pro Glu Arg Pro 
        35                  40                  45              


Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr Leu Thr Gly Arg 
    50                  55                  60                  


Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg Ser Glu Ser Asp 
65                  70                  75                  80  


Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro Tyr Ala Thr Thr 
                85                  90                  95      


Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu Met Gly Arg Arg 
            100                 105                 110         


Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly Asp Glu Glu Asp 
        115                 120                 125             


Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu Gly Asp Val Ser 
    130                 135                 140                 


Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu Tyr Ala Val Pro 
145                 150                 155                 160 


His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn Ser Glu Asp Asp 
                165                 170                 175     


Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser Pro Pro Ala Pro 
            180                 185                 190         


Gln Arg Thr Gln Gln Lys Asp Gly Lys His Pro Val Leu Asn Leu Lys 
        195                 200                 205             


Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro Ser Pro Asp Ile 
    210                 215                 220                 


Thr Gly Arg Ala Arg Gln Arg Tyr Thr Glu Ile Thr Arg Glu Lys Phe 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Glu Asn Met Asp Leu Asn Asn Met Asn Gln Ser 
                245                 250                 255     


Leu Thr Leu Glu Leu Asn Thr Met Lys Gln Ala Met Lys Glu Leu Gln 
            260                 265                 270         


Leu Lys Leu Lys Gly Met Glu Lys Glu Lys Arg Lys Leu Lys Glu Ala 
        275                 280                 285             


Glu Lys Ala Ser Ser Gln Glu Val Ala Ala Pro Glu Leu Leu Tyr Leu 
    290                 295                 300                 


Arg Lys Gln Ala Gln Glu Leu Val Asp Glu Asn Asp Gly Leu Lys Met 
305                 310                 315                 320 


Thr Val His Arg Leu Asn Val Glu Leu Ser Arg Tyr Gln Thr Lys Phe 
                325                 330                 335     


Arg His Leu Ser Lys Glu Glu Ser Leu Asn Ile Glu Gly Leu Pro Ser 
            340                 345                 350         


Lys Gly Pro Ile Pro Pro Trp Leu Leu Asp Ile Lys Tyr Leu Ser Pro 
        355                 360                 365             


Leu Leu Leu Ala Tyr Glu Asp Met Met Lys Glu Lys Asp Glu Leu Asn 
    370                 375                 380                 


Ala Thr Leu Lys Glu Glu Met Arg Met Phe Arg Met Arg Val Gln Glu 
385                 390                 395                 400 


Val Val Lys Glu Asn Glu Glu Leu His Gln Glu Leu Asn Lys Ser Ser 
                405                 410                 415     


Ala Val Thr Ser Glu Glu Trp Arg Gln Leu Gln Thr Gln Ala Lys Leu 
            420                 425                 430         


Val Leu Glu Glu Asn Lys Leu Leu Leu Glu Gln Leu Glu Ile Gln Gln 
        435                 440                 445             


Arg Lys Ala Lys Asp Ser His Gln Glu Arg Leu Gln Glu Val Ser Lys 
    450                 455                 460                 


Leu Thr Lys Gln Leu Met Leu Leu Glu Ala Lys Thr His Gly Gln Glu 
465                 470                 475                 480 


Lys Glu Leu Ala Glu Asn Arg Glu Gln Leu Glu Ile Leu Arg Ala Lys 
                485                 490                 495     


Cys Gln Glu Leu Lys Thr His Ser Asp Gly Lys Ile Ala Val Glu Val 
            500                 505                 510         


His Lys Ser Ile Val Asn Glu Leu Lys Ser Gln Leu Gln Lys Glu Glu 
        515                 520                 525             


Glu Lys Glu Arg Ala Glu Met Glu Glu Leu Met Glu Lys Leu Thr Val 
    530                 535                 540                 


Leu Gln Ala Gln Lys Lys Ser Leu Leu Leu Glu Lys Asn Ser Leu Thr 
545                 550                 555                 560 


Glu Gln Asn Lys Ala Leu Glu Ala Glu Leu Glu Arg Ala Gln Lys Ile 
                565                 570                 575     


Asn Arg Lys Ser Gln Lys Lys Ile Glu Val Leu Lys Lys Gln Val Glu 
            580                 585                 590         


Lys Ala Met Gly Asn Glu Met Ser Ala His Gln Tyr Leu Ala Asn Leu 
        595                 600                 605             


Val Gly Leu Ala Glu Asn Ile Thr Gln Glu Arg Asp Ser Leu Met Cys 
    610                 615                 620                 


Leu Ala Lys Cys Leu Glu Ser Glu Lys Asp Gly Val Leu Asn Lys Val 
625                 630                 635                 640 


Ile Lys Ser Asn Ile Arg Leu Gly Lys Leu Glu Glu Lys Val Lys Gly 
                645                 650                 655     


Tyr Lys Lys Gln Ala Ala Leu Lys Leu Gly Asp Ile Ser His Arg Leu 
            660                 665                 670         


Leu Glu Gln Gln Glu Asp Phe Ala Gly Lys Thr Ala Gln Tyr Arg Gln 
        675                 680                 685             


Glu Met Arg His Leu His Gln Val Leu Lys Asp Lys Gln Glu Val Leu 
    690                 695                 700                 


Asp Gln Ala Leu Gln Gln Asn Arg Glu Met Glu Gly Glu Leu Glu Val 
705                 710                 715                 720 


Ile Trp Glu Ser Thr Phe Arg Glu Asn Arg Arg Ile Arg Glu Leu Leu 
                725                 730                 735     


Gln Asp Thr Leu Thr Arg Thr Gly Val Gln Asp Asn Pro Arg Ala Leu 
            740                 745                 750         


Val Ala Pro Ser Leu Asn Gly Val Ser Gln Ala Asp Leu Leu Asp Gly 
        755                 760                 765             


Cys Asp Val Cys Ser Tyr Asp Leu Lys Ser His Ala Pro Thr Cys 
    770                 775                 780             


<210> 5256
<211> 212
<212> PRT
<213> Homo sapiens

<400> 5256
Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210> 5257
<211> 167
<212> PRT
<213> Homo sapiens

<400> 5257
Met Glu Glu Thr Tyr Thr Asp Ser Leu Asp Pro Glu Lys Leu Leu Gln 
1               5                   10                  15      


Cys Pro Tyr Asp Lys Asn His Gln Ile Arg Ala Cys Arg Phe Pro Tyr 
            20                  25                  30          


His Leu Ile Lys Cys Arg Lys Asn His Pro Asp Val Ala Ser Lys Leu 
        35                  40                  45              


Ala Thr Cys Pro Phe Asn Ala Arg His Gln Val Pro Arg Ala Glu Ile 
    50                  55                  60                  


Ser His His Ile Ser Ser Cys Asp Asp Arg Ser Cys Ile Glu Gln Asp 
65                  70                  75                  80  


Val Val Asn Gln Thr Arg Ser Leu Arg Gln Glu Thr Leu Ala Glu Ser 
                85                  90                  95      


Thr Trp Gln Cys Pro Pro Cys Asp Glu Asp Trp Asp Lys Asp Leu Trp 
            100                 105                 110         


Glu Gln Thr Ser Thr Pro Phe Val Trp Gly Thr Thr His Tyr Ser Asp 
        115                 120                 125             


Asn Asn Ser Pro Ala Ser Asn Ile Val Thr Glu His Lys Asn Asn Leu 
    130                 135                 140                 


Ala Ser Gly Met Arg Val Pro Lys Ser Leu Pro Tyr Val Leu Pro Trp 
145                 150                 155                 160 


Lys Asn Asn Gly Asn Ala Gln 
                165         


<210> 5258
<211> 126
<212> PRT
<213> Homo sapiens

<400> 5258
Met Ala Ala Gly Pro Glu Pro Pro Glu Trp Glu Pro Arg Trp Arg Lys 
1               5                   10                  15      


Ala Leu Arg Gly Lys Glu Asn Lys Gly Ser Val Glu Ile Met Arg Lys 
            20                  25                  30          


Asp Leu Asn Asp Ala Arg Asp Leu His Gly Gln Ala Glu Ser Ala Ala 
        35                  40                  45              


Ala Val Trp Lys Gly His Val Met Asp Arg Arg Lys Lys Ala Leu Thr 
    50                  55                  60                  


Asp Tyr Lys Lys Leu Arg Ala Phe Phe Val Glu Glu Glu Glu His Phe 
65                  70                  75                  80  


Leu Gln Glu Ala Glu Lys Glu Glu Gly Leu Pro Glu Asp Glu Leu Ala 
                85                  90                  95      


Asp Pro Thr Glu Arg Phe Arg Ser Leu Leu Gln Ala Val Ser Glu Leu 
            100                 105                 110         


Glu Lys Lys His Arg Asn Leu Gly Leu Ser Met Leu Leu Gln 
        115                 120                 125     


<210> 5259
<211> 555
<212> PRT
<213> Homo sapiens

<400> 5259
Met Gln Ser Cys Glu Ser Ser Gly Asp Ser Ala Asp Asp Pro Leu Ser 
1               5                   10                  15      


Arg Gly Leu Arg Arg Arg Gly Gln Pro Arg Val Val Val Ile Gly Ala 
            20                  25                  30          


Gly Leu Ala Gly Leu Ala Ala Ala Lys Ala Leu Leu Glu Gln Gly Phe 
        35                  40                  45              


Thr Asp Val Thr Val Leu Glu Ala Ser Ser His Ile Gly Gly Arg Val 
    50                  55                  60                  


Gln Ser Val Lys Leu Gly His Ala Thr Phe Glu Leu Gly Ala Thr Trp 
65                  70                  75                  80  


Ile His Gly Ser His Gly Asn Pro Ile Tyr His Leu Ala Glu Ala Asn 
                85                  90                  95      


Gly Leu Leu Glu Glu Thr Thr Asp Gly Glu Arg Ser Val Gly Arg Ile 
            100                 105                 110         


Ser Leu Tyr Ser Lys Asn Gly Val Ala Cys Tyr Leu Thr Asn His Gly 
        115                 120                 125             


Arg Arg Ile Pro Lys Asp Val Val Glu Glu Phe Ser Asp Leu Tyr Asn 
    130                 135                 140                 


Glu Val Tyr Asn Leu Thr Gln Glu Phe Phe Arg His Asp Lys Pro Val 
145                 150                 155                 160 


Asn Ala Glu Ser Gln Asn Ser Val Gly Val Phe Thr Arg Glu Glu Val 
                165                 170                 175     


Arg Asn Arg Ile Arg Asn Asp Pro Asp Asp Pro Glu Ala Thr Lys Arg 
            180                 185                 190         


Leu Lys Leu Ala Met Ile Gln Gln Tyr Leu Lys Val Glu Ser Cys Glu 
        195                 200                 205             


Ser Ser Ser His Ser Met Asp Glu Val Ser Leu Ser Ala Phe Gly Glu 
    210                 215                 220                 


Trp Thr Glu Ile Pro Gly Ala His His Ile Ile Pro Ser Gly Phe Met 
225                 230                 235                 240 


Arg Val Val Glu Leu Leu Ala Glu Gly Ile Pro Ala His Val Ile Gln 
                245                 250                 255     


Leu Gly Lys Pro Val Arg Cys Ile His Trp Asp Gln Ala Ser Ala Arg 
            260                 265                 270         


Pro Arg Gly Pro Glu Ile Glu Pro Arg Gly Glu Gly Asp His Asn His 
        275                 280                 285             


Asp Thr Gly Glu Gly Gly Gln Gly Gly Glu Glu Pro Arg Gly Gly Arg 
    290                 295                 300                 


Trp Asp Glu Asp Glu Gln Trp Ser Val Val Val Glu Cys Glu Asp Cys 
305                 310                 315                 320 


Glu Leu Ile Pro Ala Asp His Val Ile Val Thr Val Ser Leu Gly Val 
                325                 330                 335     


Leu Lys Arg Gln Tyr Thr Ser Phe Phe Arg Pro Gly Leu Pro Thr Glu 
            340                 345                 350         


Lys Val Ala Ala Ile His Arg Leu Gly Ile Gly Thr Thr Asp Lys Ile 
        355                 360                 365             


Phe Leu Glu Phe Glu Glu Pro Phe Trp Gly Pro Glu Cys Asn Ser Leu 
    370                 375                 380                 


Gln Phe Val Trp Glu Asp Glu Ala Glu Ser His Thr Leu Thr Tyr Pro 
385                 390                 395                 400 


Pro Glu Leu Trp Tyr Arg Lys Ile Cys Gly Phe Asp Val Leu Tyr Pro 
                405                 410                 415     


Pro Glu Arg Tyr Gly His Val Leu Ser Gly Trp Ile Cys Gly Glu Glu 
            420                 425                 430         


Ala Leu Val Met Glu Lys Cys Asp Asp Glu Ala Val Ala Glu Ile Cys 
        435                 440                 445             


Thr Glu Met Leu Arg Gln Phe Thr Gly Asn Pro Asn Ile Pro Lys Pro 
    450                 455                 460                 


Arg Arg Ile Leu Arg Ser Ala Trp Gly Ser Asn Pro Tyr Phe Arg Gly 
465                 470                 475                 480 


Ser Tyr Ser Tyr Thr Gln Val Gly Ser Ser Gly Ala Asp Val Glu Lys 
                485                 490                 495     


Leu Ala Lys Pro Leu Pro Tyr Thr Glu Ser Ser Lys Thr Ala Pro Met 
            500                 505                 510         


Gln Val Leu Phe Ser Gly Glu Ala Thr His Arg Lys Tyr Tyr Ser Thr 
        515                 520                 525             


Thr His Gly Ala Leu Leu Ser Gly Gln Arg Glu Ala Ala Arg Leu Ile 
    530                 535                 540                 


Glu Met Tyr Arg Asp Leu Phe Gln Gln Gly Thr 
545                 550                 555 


<210> 5260
<211> 1050
<212> PRT
<213> Homo sapiens

<400> 5260
Met Ala Leu Tyr Asp Glu Asp Leu Leu Lys Asn Pro Phe Tyr Leu Ala 
1               5                   10                  15      


Leu Gln Lys Cys Arg Pro Asp Leu Cys Ser Lys Val Ala Gln Ile His 
            20                  25                  30          


Gly Ile Val Leu Val Pro Cys Lys Gly Ser Leu Ser Ser Ser Ile Gln 
        35                  40                  45              


Ser Thr Cys Gln Phe Glu Ser Tyr Ile Leu Ile Pro Val Glu Glu His 
    50                  55                  60                  


Phe Gln Thr Leu Asn Gly Lys Asp Val Phe Ile Gln Gly Asn Arg Ile 
65                  70                  75                  80  


Lys Leu Gly Ala Gly Phe Ala Cys Leu Leu Ser Val Pro Ile Leu Phe 
                85                  90                  95      


Glu Glu Thr Phe Tyr Asn Glu Lys Glu Glu Ser Phe Ser Ile Leu Cys 
            100                 105                 110         


Ile Ala His Pro Leu Glu Lys Arg Glu Ser Ser Glu Glu Pro Leu Ala 
        115                 120                 125             


Pro Ser Asp Pro Phe Ser Leu Lys Thr Ile Glu Asp Val Arg Glu Phe 
    130                 135                 140                 


Leu Gly Arg His Ser Glu Arg Phe Asp Arg Asn Ile Ala Ser Phe His 
145                 150                 155                 160 


Arg Thr Phe Arg Glu Cys Glu Arg Lys Ser Leu Arg His His Ile Asp 
                165                 170                 175     


Ser Ala Asn Ala Leu Tyr Thr Lys Cys Leu Gln Gln Leu Leu Arg Asp 
            180                 185                 190         


Ser His Leu Lys Met Leu Ala Lys Gln Glu Ala Gln Met Asn Leu Met 
        195                 200                 205             


Lys Gln Ala Val Glu Ile Tyr Val His His Glu Ile Tyr Asn Leu Ile 
    210                 215                 220                 


Phe Lys Tyr Val Gly Thr Met Glu Ala Ser Glu Asp Ala Ala Phe Asn 
225                 230                 235                 240 


Lys Ile Thr Arg Ser Leu Gln Asp Leu Gln Gln Lys Asp Ile Gly Val 
                245                 250                 255     


Lys Pro Glu Phe Ser Phe Asn Ile Pro Arg Ala Lys Arg Glu Leu Ala 
            260                 265                 270         


Gln Leu Asn Lys Cys Thr Ser Pro Gln Gln Lys Leu Val Cys Leu Arg 
        275                 280                 285             


Lys Val Val Gln Leu Ile Thr Gln Ser Pro Ser Gln Arg Val Asn Leu 
    290                 295                 300                 


Glu Thr Met Cys Ala Asp Asp Leu Leu Ser Val Leu Leu Tyr Leu Leu 
305                 310                 315                 320 


Val Lys Thr Glu Ile Pro Asn Trp Met Ala Asn Leu Ser Tyr Ile Lys 
                325                 330                 335     


Asn Phe Arg Phe Ser Ser Leu Ala Lys Asp Glu Leu Gly Tyr Cys Leu 
            340                 345                 350         


Thr Ser Phe Glu Ala Ala Ile Glu Tyr Ile Arg Gln Gly Ser Leu Ser 
        355                 360                 365             


Ala Lys Pro Pro Glu Ser Glu Gly Phe Gly Asp Arg Leu Phe Leu Lys 
    370                 375                 380                 


Gln Arg Met Ser Leu Leu Ser Gln Met Thr Ser Ser Pro Thr Asp Cys 
385                 390                 395                 400 


Leu Phe Lys His Ile Ala Ser Gly Asn Gln Lys Glu Val Glu Arg Leu 
                405                 410                 415     


Leu Ser Gln Glu Asp His Asp Lys Asp Thr Val Gln Lys Met Cys His 
            420                 425                 430         


Pro Leu Cys Phe Cys Asp Asp Cys Glu Lys Leu Val Ser Gly Arg Leu 
        435                 440                 445             


Asn Asp Pro Ser Val Val Thr Pro Phe Ser Arg Asp Asp Arg Gly His 
    450                 455                 460                 


Thr Pro Leu His Val Ala Ala Val Cys Gly Gln Ala Ser Leu Ile Asp 
465                 470                 475                 480 


Leu Leu Val Ser Lys Gly Ala Met Val Asn Ala Thr Asp Tyr His Gly 
                485                 490                 495     


Ala Thr Pro Leu His Leu Ala Cys Gln Lys Gly Tyr Gln Ser Val Thr 
            500                 505                 510         


Leu Leu Leu Leu His Tyr Lys Ala Ser Ala Glu Val Gln Asp Asn Asn 
        515                 520                 525             


Gly Asn Thr Pro Leu His Leu Ala Cys Thr Tyr Gly His Glu Asp Cys 
    530                 535                 540                 


Val Lys Ala Leu Val Tyr Tyr Asp Val Glu Ser Cys Arg Leu Asp Ile 
545                 550                 555                 560 


Gly Asn Glu Lys Gly Asp Thr Pro Leu His Ile Ala Ala Arg Trp Gly 
                565                 570                 575     


Tyr Gln Gly Val Ile Glu Thr Leu Leu Gln Asn Gly Ala Ser Thr Glu 
            580                 585                 590         


Ile Gln Asn Arg Leu Lys Glu Thr Pro Leu Lys Cys Ala Leu Asn Ser 
        595                 600                 605             


Lys Ile Leu Ser Val Met Glu Ala Tyr His Leu Ser Phe Glu Arg Arg 
    610                 615                 620                 


Gln Lys Ser Ser Glu Ala Pro Val Gln Ser Pro Gln Arg Ser Val Asp 
625                 630                 635                 640 


Ser Ile Ser Gln Glu Ser Ser Thr Ser Ser Phe Ser Ser Met Ser Ala 
                645                 650                 655     


Ser Ser Arg Gln Glu Glu Thr Lys Lys Asp Tyr Arg Glu Val Glu Lys 
            660                 665                 670         


Leu Leu Arg Ala Val Ala Asp Gly Asp Leu Glu Met Val Arg Tyr Leu 
        675                 680                 685             


Leu Glu Trp Thr Glu Glu Asp Leu Glu Asp Ala Glu Asp Thr Val Ser 
    690                 695                 700                 


Ala Ala Asp Pro Glu Phe Cys His Pro Leu Cys Gln Cys Pro Lys Cys 
705                 710                 715                 720 


Ala Pro Ala Gln Lys Arg Leu Ala Lys Val Pro Ala Ser Gly Leu Gly 
                725                 730                 735     


Val Asn Val Thr Ser Gln Asp Gly Ser Ser Pro Leu His Val Ala Ala 
            740                 745                 750         


Leu His Gly Arg Ala Asp Leu Ile Pro Leu Leu Leu Lys His Gly Ala 
        755                 760                 765             


Asn Ala Gly Ala Arg Asn Ala Asp Gln Ala Val Pro Leu His Leu Ala 
    770                 775                 780                 


Cys Gln Gln Gly His Phe Gln Val Val Lys Cys Leu Leu Asp Ser Asn 
785                 790                 795                 800 


Ala Lys Pro Asn Lys Lys Asp Leu Ser Gly Asn Thr Pro Leu Ile Tyr 
                805                 810                 815     


Ala Cys Ser Gly Gly His His Glu Leu Val Ala Leu Leu Leu Gln His 
            820                 825                 830         


Gly Ala Ser Ile Asn Ala Ser Asn Asn Lys Gly Asn Thr Ala Leu His 
        835                 840                 845             


Glu Ala Val Ile Glu Lys His Val Phe Val Val Glu Leu Leu Leu Leu 
    850                 855                 860                 


His Gly Ala Ser Val Gln Val Leu Asn Lys Arg Gln Arg Thr Ala Val 
865                 870                 875                 880 


Asp Cys Ala Glu Gln Asn Ser Lys Ile Met Glu Leu Leu Gln Val Val 
                885                 890                 895     


Pro Ser Cys Val Ala Ser Leu Asp Asp Val Ala Glu Thr Asp Arg Lys 
            900                 905                 910         


Glu Tyr Val Thr Val Lys Ile Arg Lys Lys Trp Asn Ser Lys Leu Tyr 
        915                 920                 925             


Asp Leu Pro Asp Glu Pro Phe Thr Arg Gln Phe Tyr Phe Val His Ser 
    930                 935                 940                 


Ala Gly Gln Phe Lys Gly Lys Thr Ser Arg Glu Ile Met Ala Arg Asp 
945                 950                 955                 960 


Arg Ser Val Pro Asn Leu Thr Glu Gly Ser Leu His Glu Pro Gly Arg 
                965                 970                 975     


Gln Ser Val Thr Leu Arg Gln Asn Asn Leu Pro Ala Gln Ser Gly Ser 
            980                 985                 990         


His Ala Ala Glu Lys Gly Asn Ser  Asp Trp Pro Glu Arg  Pro Gly Leu 
        995                 1000                 1005             


Thr Gln  Thr Gly Pro Gly His  Arg Arg Met Leu Arg  Arg His Thr 
    1010                 1015                 1020             


Val Glu  Asp Ala Val Val Ser  Gln Gly Pro Glu Ala  Ala Gly Pro 
    1025                 1030                 1035             


Leu Ser  Thr Pro Gln Glu Val  Ser Ala Ser Arg Ser  
    1040                 1045                 1050 


<210> 5261
<211> 553
<212> PRT
<213> Homo sapiens

<400> 5261
Met Asp Val Asp Lys Glu Leu Gly Met Glu Ser Val Lys Ala Gly Ala 
1               5                   10                  15      


Ser Gly Lys Pro Glu Met Arg Leu Gly Thr Gln Glu Glu Thr Ser Glu 
            20                  25                  30          


Gly Asp Ala Asn Glu Ser Ser Leu Leu Val Leu Ser Ser Asn Val Pro 
        35                  40                  45              


Leu Leu Ala Leu Glu Phe Leu Glu Ile Ala Gln Ala Lys Glu Lys Ala 
    50                  55                  60                  


Phe Leu Pro Met Val Ser His Thr Phe His Met Arg Thr Glu Glu Ser 
65                  70                  75                  80  


Asp Ala Ser Gln Glu Gly Asp Asp Leu Pro Lys Ser Ser Ala Asn Thr 
                85                  90                  95      


Ser His Pro Lys Gln Asp Asp Ser Pro Lys Ser Ser Glu Glu Thr Ile 
            100                 105                 110         


Gln Pro Lys Glu Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln 
        115                 120                 125             


Ser Lys Lys Glu Asp Leu Pro Lys Ser Ser Glu Lys Ala Ile Gln Pro 
    130                 135                 140                 


Lys Glu Ser Asn Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys 
145                 150                 155                 160 


Leu Gly Asn Ile Pro Lys Ala Ser Val Lys Pro Ser Gln Pro Lys Glu 
                165                 170                 175     


Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys Glu 
            180                 185                 190         


Asp Leu Pro Lys Ser Ser Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp 
        195                 200                 205             


Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile 
    210                 215                 220                 


Ala Lys Thr Ser Val Lys Pro Ser Gln Pro Lys Glu Ser Asp Ile Pro 
225                 230                 235                 240 


Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys 
                245                 250                 255     


Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Pro Lys Ala 
            260                 265                 270         


Ser Val Lys Pro Ser Gln Pro Lys Glu Gly Asp Ile Ser Lys Ser Pro 
        275                 280                 285             


Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Leu Pro Lys Ser Leu Glu 
    290                 295                 300                 


Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu 
305                 310                 315                 320 


Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala 
                325                 330                 335     


Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile 
            340                 345                 350         


Gln Pro Lys Lys Gly Asp Ile Pro Lys Ser Pro Glu Glu Ala Ile Gln 
        355                 360                 365             


Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Lys Gln Ala Ile Gln Pro 
    370                 375                 380                 


Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala Ile Pro Pro Lys 
385                 390                 395                 400 


Glu Ile Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu 
                405                 410                 415     


Asp Asp Ser Pro Lys Ser Leu Glu Glu Ala Thr Pro Ser Lys Glu Gly 
            420                 425                 430         


Asp Ile Leu Lys Pro Glu Glu Glu Thr Met Glu Phe Pro Glu Gly Asp 
        435                 440                 445             


Lys Val Lys Val Ile Leu Ser Lys Glu Asp Phe Glu Ala Ser Leu Lys 
    450                 455                 460                 


Glu Ala Gly Glu Arg Leu Val Ala Val Asp Phe Ser Ala Thr Trp Cys 
465                 470                 475                 480 


Gly Pro Cys Arg Thr Ile Arg Pro Phe Phe His Ala Leu Ser Val Lys 
                485                 490                 495     


His Glu Asp Val Val Phe Leu Glu Val Asp Ala Asp Asn Cys Glu Glu 
            500                 505                 510         


Val Val Arg Glu Cys Ala Ile Met Cys Val Pro Thr Phe Gln Phe Tyr 
        515                 520                 525             


Lys Lys Glu Glu Lys Val Asp Glu Leu Cys Gly Ala Leu Lys Glu Lys 
    530                 535                 540                 


Leu Glu Ala Val Ile Ala Glu Leu Lys 
545                 550             


<210> 5262
<211> 755
<212> PRT
<213> Homo sapiens

<400> 5262
Met Val Ser His Gly Ser Ser Pro Ser Leu Leu Glu Ala Leu Ser Ser 
1               5                   10                  15      


Asp Phe Leu Ala Cys Lys Ile Cys Leu Glu Gln Leu Arg Ala Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Leu His Thr Tyr Cys Gln Asp Cys Leu Ala Gln Leu 
        35                  40                  45              


Ala Asp Gly Gly Arg Val Arg Cys Pro Glu Cys Arg Glu Thr Val Pro 
    50                  55                  60                  


Val Pro Pro Glu Gly Val Ala Ser Phe Lys Thr Asn Phe Phe Val Asn 
65                  70                  75                  80  


Gly Leu Leu Asp Leu Val Lys Ala Arg Ala Cys Gly Asp Leu Arg Ala 
                85                  90                  95      


Gly Lys Pro Ala Cys Ala Leu Cys Pro Leu Val Gly Gly Thr Ser Thr 
            100                 105                 110         


Gly Gly Pro Ala Thr Ala Arg Cys Leu Asp Cys Ala Asp Asp Leu Cys 
        115                 120                 125             


Gln Ala Cys Ala Asp Gly His Arg Cys Thr Arg Gln Thr His Thr His 
    130                 135                 140                 


Arg Val Val Asp Leu Val Gly Tyr Arg Ala Gly Trp Tyr Asp Glu Glu 
145                 150                 155                 160 


Ala Arg Glu Arg Gln Ala Ala Gln Cys Pro Gln His Pro Gly Glu Ala 
                165                 170                 175     


Leu Arg Phe Leu Cys Gln Pro Cys Ser Gln Leu Leu Cys Arg Glu Cys 
            180                 185                 190         


Arg Leu Asp Pro His Leu Asp His Pro Cys Leu Pro Leu Ala Glu Ala 
        195                 200                 205             


Val Arg Ala Arg Arg Pro Gly Leu Glu Gly Leu Leu Ala Gly Val Asp 
    210                 215                 220                 


Asn Asn Leu Val Glu Leu Glu Ala Ala Arg Arg Val Glu Lys Glu Ala 
225                 230                 235                 240 


Leu Ala Arg Leu Arg Glu Gln Ala Ala Arg Val Gly Thr Gln Val Glu 
                245                 250                 255     


Glu Ala Ala Glu Gly Val Leu Arg Ala Leu Leu Ala Gln Lys Gln Glu 
            260                 265                 270         


Val Leu Gly Gln Leu Arg Ala His Val Glu Ala Ala Glu Glu Ala Ala 
        275                 280                 285             


Arg Glu Arg Leu Ala Glu Leu Glu Gly Arg Glu Gln Val Ala Arg Ala 
    290                 295                 300                 


Ala Ala Ala Phe Ala Arg Arg Val Leu Ser Leu Gly Arg Glu Ala Glu 
305                 310                 315                 320 


Ile Leu Ser Leu Glu Gly Ala Ile Ala Gln Arg Leu Arg Gln Leu Gln 
                325                 330                 335     


Gly Cys Pro Trp Ala Pro Gly Pro Ala Pro Cys Leu Leu Pro Gln Leu 
            340                 345                 350         


Glu Leu His Pro Gly Leu Leu Asp Lys Asn Cys His Leu Leu Arg Leu 
        355                 360                 365             


Ser Phe Glu Glu Gln Gln Pro Gln Lys Asp Gly Gly Lys Asp Gly Ala 
    370                 375                 380                 


Gly Thr Gln Gly Gly Glu Glu Ser Gln Ser Arg Arg Glu Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Arg Gln Gly Gly Val Gln Pro Gln Ala Gly Asp Gly Ala 
                405                 410                 415     


Gln Thr Pro Lys Glu Glu Lys Ala Gln Thr Thr Arg Glu Glu Gly Ala 
            420                 425                 430         


Gln Thr Leu Glu Glu Asp Arg Ala Gln Thr Pro His Glu Asp Gly Gly 
        435                 440                 445             


Pro Gln Pro His Arg Gly Gly Arg Pro Asn Lys Lys Lys Lys Phe Lys 
    450                 455                 460                 


Gly Arg Leu Lys Ser Ile Ser Arg Glu Pro Ser Pro Ala Leu Gly Pro 
465                 470                 475                 480 


Asn Leu Asp Gly Ser Gly Leu Leu Pro Arg Pro Ile Phe Tyr Cys Ser 
                485                 490                 495     


Phe Pro Thr Arg Met Pro Gly Asp Lys Arg Ser Pro Arg Ile Thr Gly 
            500                 505                 510         


Leu Cys Pro Phe Gly Pro Arg Glu Ile Leu Val Ala Asp Glu Gln Asn 
        515                 520                 525             


Arg Ala Leu Lys Arg Phe Ser Leu Asn Gly Asp Tyr Lys Gly Thr Val 
    530                 535                 540                 


Pro Val Pro Glu Gly Cys Ser Pro Cys Ser Val Ala Ala Leu Gln Ser 
545                 550                 555                 560 


Ala Val Ala Phe Ser Ala Ser Ala Arg Leu Tyr Leu Ile Asn Pro Asn 
                565                 570                 575     


Gly Glu Val Gln Trp Arg Arg Ala Leu Ser Leu Ser Gln Ala Ser His 
            580                 585                 590         


Ala Val Ala Ala Leu Pro Ser Gly Asp Arg Val Ala Val Ser Val Ala 
        595                 600                 605             


Gly His Val Glu Val Tyr Asn Met Glu Gly Ser Leu Ala Thr Arg Phe 
    610                 615                 620                 


Ile Pro Gly Gly Lys Ala Ser Arg Gly Leu Arg Ala Leu Val Phe Leu 
625                 630                 635                 640 


Thr Thr Ser Pro Gln Gly His Phe Val Gly Ser Asp Trp Gln Gln Asn 
                645                 650                 655     


Ser Val Val Ile Cys Asp Gly Leu Gly Gln Val Val Gly Glu Tyr Lys 
            660                 665                 670         


Gly Pro Gly Leu His Gly Cys Gln Pro Gly Ser Val Ser Val Asp Lys 
        675                 680                 685             


Lys Gly Tyr Ile Phe Leu Thr Leu Arg Glu Val Asn Lys Val Val Ile 
    690                 695                 700                 


Leu Asp Pro Lys Gly Ser Leu Leu Gly Asp Phe Leu Thr Ala Tyr His 
705                 710                 715                 720 


Gly Leu Glu Lys Pro Arg Val Thr Thr Met Val Asp Gly Arg Tyr Leu 
                725                 730                 735     


Val Val Ser Leu Ser Asn Gly Thr Ile His Ile Phe Arg Val Arg Ser 
            740                 745                 750         


Pro Asp Ser 
        755 


<210> 5263
<211> 488
<212> PRT
<213> Homo sapiens

<400> 5263
Met Ala Ala Gly Ser Glu Ala Thr Thr Pro Val Ile Val Ala Ala Gly 
1               5                   10                  15      


Ala Gly Gly Glu Glu Gly Glu His Val Lys Pro Phe Lys Pro Glu Lys 
            20                  25                  30          


Ala Lys Glu Ile Ile Met Ser Leu Gln Gln Pro Ala Ile Phe Cys Asn 
        35                  40                  45              


Met Val Phe Asp Trp Pro Ala Arg His Trp Asn Ala Lys Tyr Leu Ser 
    50                  55                  60                  


Gln Val Leu His Gly Lys Gln Ile Arg Phe Arg Met Gly Met Lys Ser 
65                  70                  75                  80  


Met Ser Thr Val Pro Gln Phe Glu Thr Thr Cys Asn Tyr Val Glu Ala 
                85                  90                  95      


Thr Leu Glu Glu Phe Leu Thr Trp Asn Cys Asp Gln Ser Ser Ile Ser 
            100                 105                 110         


Gly Pro Phe Arg Asp Tyr Asp His Ser Lys Phe Trp Ala Tyr Ala Asp 
        115                 120                 125             


Tyr Lys Tyr Phe Val Ser Leu Phe Glu Asp Lys Thr Asp Leu Phe Gln 
    130                 135                 140                 


Asp Val Lys Trp Ser Asp Phe Gly Phe Pro Gly Arg Asn Gly Gln Glu 
145                 150                 155                 160 


Ser Thr Leu Trp Ile Gly Ser Leu Gly Ala His Thr Pro Cys His Leu 
                165                 170                 175     


Asp Ser Tyr Gly Cys Asn Leu Val Phe Gln Val Gln Gly Arg Lys Arg 
            180                 185                 190         


Trp His Leu Phe Pro Pro Glu Asp Thr Pro Phe Leu Tyr Pro Thr Arg 
        195                 200                 205             


Ile Pro Tyr Glu Glu Ser Ser Val Phe Ser Lys Ile Asn Val Val Asn 
    210                 215                 220                 


Pro Asp Leu Lys Arg Phe Pro Gln Phe Arg Lys Ala Gln Arg His Ala 
225                 230                 235                 240 


Val Thr Leu Ser Pro Gly Gln Val Leu Phe Val Pro Arg His Trp Trp 
                245                 250                 255     


His Tyr Val Glu Ser Ile Asp Pro Val Thr Val Ser Ile Asn Ser Trp 
            260                 265                 270         


Ile Glu Leu Glu Glu Asp His Leu Ala Arg Val Glu Glu Ala Ile Thr 
        275                 280                 285             


Arg Met Leu Val Cys Ala Leu Lys Thr Ala Glu Asn Pro Gln Asn Thr 
    290                 295                 300                 


Arg Ala Trp Leu Asn Pro Thr Glu Val Glu Glu Thr Ser His Ala Val 
305                 310                 315                 320 


Asn Cys Cys Tyr Leu Asn Ala Ala Val Ser Ala Phe Phe Asp Arg Cys 
                325                 330                 335     


Arg Thr Ser Glu Val Val Glu Ile Gln Ala Leu Arg Thr Asp Gly Glu 
            340                 345                 350         


His Met Lys Lys Glu Glu Leu Asn Val Cys Asn His Met Glu Val Gly 
        355                 360                 365             


Gln Thr Gly Ser Gln Asn Leu Thr Thr Gly Thr Asp Lys Pro Glu Ala 
    370                 375                 380                 


Ala Ser Pro Phe Gly Pro Asp Leu Val Pro Val Ala Gln Arg Ser Glu 
385                 390                 395                 400 


Glu Pro Pro Ser Glu Arg Gly Gly Ile Phe Gly Ser Asp Gly Lys Asp 
                405                 410                 415     


Phe Val Asp Lys Asp Gly Glu His Phe Gly Lys Leu His Cys Ala Lys 
            420                 425                 430         


Arg Gln Gln Ile Met Ser Asn Ser Glu Asn Ala Ile Glu Glu Gln Ile 
        435                 440                 445             


Ala Ser Asn Thr Thr Thr Thr Pro Gln Thr Phe Ile Ser Thr Asp Asp 
    450                 455                 460                 


Leu Leu Asp Cys Leu Val Asn Pro Gln Val Thr Arg Ile Val Ala Gln 
465                 470                 475                 480 


Leu Leu Ile Gln Gly Arg Ser Leu 
                485             


<210> 5264
<211> 192
<212> PRT
<213> Homo sapiens

<400> 5264
Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


<210> 5265
<211> 153
<212> PRT
<213> Homo sapiens

<400> 5265
Met Thr Ser Glu Ser Thr Ser Pro Pro Val Val Pro Pro Leu His Ser 
1               5                   10                  15      


Pro Lys Ser Pro Val Trp Pro Thr Phe Pro Phe His Arg Glu Gly Ser 
            20                  25                  30          


Arg Val Trp Glu Arg Gly Gly Val Pro Pro Arg Asp Leu Pro Ser Pro 
        35                  40                  45              


Leu Pro Thr Lys Arg Thr Arg Thr Tyr Ser Ala Thr Ala Arg Ala Ser 
    50                  55                  60                  


Ala Gly Pro Val Phe Lys Gly Val Cys Lys Gln Phe Ser Arg Ser Gln 
65                  70                  75                  80  


Gly His Gly Phe Ile Thr Pro Glu Asn Gly Ser Glu Asp Ile Phe Val 
                85                  90                  95      


His Val Ser Asp Ile Glu Gly Glu Tyr Val Pro Val Glu Gly Asp Glu 
            100                 105                 110         


Val Thr Tyr Lys Met Cys Pro Ile Pro Pro Lys Asn Gln Lys Phe Gln 
        115                 120                 125             


Ala Val Glu Val Val Leu Thr Gln Leu Ala Pro His Thr Pro His Glu 
    130                 135                 140                 


Thr Trp Ser Gly Gln Val Val Gly Ser 
145                 150             


<210> 5266
<211> 178
<212> PRT
<213> Homo sapiens

<400> 5266
Met Ser Ser Phe Ser Arg Ala Pro Gln Gln Trp Ala Thr Phe Ala Arg 
1               5                   10                  15      


Ile Trp Tyr Leu Leu Asp Gly Lys Met Gln Pro Pro Gly Lys Leu Ala 
            20                  25                  30          


Ala Met Ala Ser Ile Arg Leu Gln Gly Leu His Lys Pro Val Tyr His 
        35                  40                  45              


Ala Leu Ser Asp Cys Gly Asp His Val Val Ile Met Asn Thr Arg His 
    50                  55                  60                  


Ile Ala Phe Ser Gly Asn Lys Trp Glu Gln Lys Val Tyr Ser Ser His 
65                  70                  75                  80  


Thr Gly Tyr Pro Gly Gly Phe Arg Gln Val Thr Ala Ala Gln Leu His 
                85                  90                  95      


Leu Arg Asp Pro Val Ala Ile Val Lys Leu Ala Ile Tyr Gly Met Leu 
            100                 105                 110         


Pro Lys Asn Leu His Arg Arg Thr Met Met Glu Arg Leu His Leu Phe 
        115                 120                 125             


Pro Asp Glu Tyr Ile Pro Glu Asp Ile Leu Lys Asn Leu Val Glu Glu 
    130                 135                 140                 


Leu Pro Gln Pro Arg Lys Ile Pro Lys Arg Leu Asp Glu Tyr Thr Gln 
145                 150                 155                 160 


Glu Glu Ile Asp Ala Phe Pro Arg Leu Trp Thr Pro Pro Glu Asp Tyr 
                165                 170                 175     


Arg Leu 
        


<210> 5267
<211> 2920
<212> PRT
<213> Homo sapiens

<400> 5267
Met Arg Gly Arg Arg Gly Arg Pro Pro Lys Gln Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Arg Cys Ala Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Thr 
            20                  25                  30          


Ser Gly Pro Ile Gly Gly Leu Arg Ser Arg His Arg Gly Ser Ser Arg 
        35                  40                  45              


Gly Arg Trp Ala Ala Ala Gln Ala Glu Val Ala Pro Lys Thr Arg Leu 
    50                  55                  60                  


Ser Ser Pro Arg Gly Gly Ser Ser Ser Arg Arg Lys Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Ser Thr Ser Ala Pro Gly Arg Gly Gly Arg Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Thr Gly Gly Gly Gly Gly Gly Gly His Leu Ala 
            100                 105                 110         


Arg Thr Thr Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp Asp 
        115                 120                 125             


His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Thr Gln Asp Ser Glu Asp 
145                 150                 155                 160 


Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr Pro 
                165                 170                 175     


Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Thr Glu Ser 
            180                 185                 190         


Ser Phe Arg Ser His Ser Thr Tyr Ser Ser Thr Pro Gly Arg Arg Lys 
        195                 200                 205             


Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp Ile 
    210                 215                 220                 


Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro Asn 
225                 230                 235                 240 


Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn Phe 
                245                 250                 255     


Gly Thr Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys Ala 
            260                 265                 270         


Ala Leu Val Ser Gln Glu Gln Cys Thr Leu Met Ala Glu Met His Val 
        275                 280                 285             


Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Thr Ser Asn Thr Thr 
    290                 295                 300                 


Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Thr Leu Tyr Phe 
305                 310                 315                 320 


Ile Asp Gly Met Thr Trp Pro Glu Val Leu Arg Val Tyr Cys Glu Ser 
                325                 330                 335     


Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp Tyr 
            340                 345                 350         


Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu Val 
        355                 360                 365             


Asp Gln Phe Leu Thr Thr Asn Ile Ala Arg Glu Glu Leu Met Ser Glu 
    370                 375                 380                 


Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Cys Cys Glu Thr Cys Ser Ala Val Tyr His Leu Glu Cys 
                405                 410                 415     


Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys Glu 
            420                 425                 430         


Val Cys Val Ala His Lys Val Pro Gly Val Thr Asp Cys Val Ala Glu 
        435                 440                 445             


Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr Asp 
    450                 455                 460                 


Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile Glu 
465                 470                 475                 480 


Glu Asp Thr Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser Thr 
                485                 490                 495     


Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr Trp 
            500                 505                 510         


Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile His 
        515                 520                 525             


Arg His Met Asp Ile Thr Glu Asp Leu Thr Asn Lys Ala Arg Gly Ser 
    530                 535                 540                 


Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu Thr 
                565                 570                 575     


Glu Lys Asp Lys Asn Glu Thr Glu Asn Asp Ser Lys Asp Ala Glu Lys 
            580                 585                 590         


Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp Asp 
        595                 600                 605             


Lys Thr Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Val Gly Asp 
    610                 615                 620                 


Phe Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala 
625                 630                 635                 640 


Gly Lys Gly Ala Ser Gly Ser Thr Arg Ile Ile Thr Arg Leu Arg Asn 
                645                 650                 655     


Pro Asp Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala 
            660                 665                 670         


Ala His Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val 
        675                 680                 685             


Val Asn Ser Gln Gly Glu Ile Ser Arg Leu Ser Thr Lys Lys Glu Val 
    690                 695                 700                 


Ile Met Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly 
705                 710                 715                 720 


Lys Tyr Arg Val Tyr His Asn Gln Tyr Ser Thr Asn Ser Phe Ala Leu 
                725                 730                 735     


Asn Lys His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala 
            740                 745                 750         


His Lys Phe Cys Leu Thr Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser 
        755                 760                 765             


Val His Gly Ser Lys Val Leu Thr Ile Ser Thr Leu Arg Leu Thr Ile 
    770                 775                 780                 


Thr Gln Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His Pro Asn Trp 
785                 790                 795                 800 


Ala Ser His Arg Ala Asn Trp Ile Lys Ala Val Gln Met Cys Ser Lys 
                805                 810                 815     


Pro Arg Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys Ala Val Lys 
            820                 825                 830         


Pro Val Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly His Thr Arg 
        835                 840                 845             


Leu His Arg Met Thr Ser Ile Glu Arg Glu Glu Lys Glu Lys Val Lys 
    850                 855                 860                 


Lys Lys Glu Lys Lys Gln Glu Glu Glu Glu Thr Met Gln Gln Ala Thr 
865                 870                 875                 880 


Trp Val Lys Tyr Thr Phe Pro Val Lys His Gln Val Trp Lys Gln Lys 
                885                 890                 895     


Gly Glu Glu Tyr Arg Val Thr Gly Tyr Gly Gly Trp Ser Trp Ile Ser 
            900                 905                 910         


Lys Thr His Val Tyr Arg Phe Val Pro Lys Leu Pro Gly Asn Thr Asn 
        915                 920                 925             


Val Asn Tyr Arg Lys Ser Leu Glu Gly Thr Lys Asn Asn Met Asp Glu 
    930                 935                 940                 


Asn Met Asp Glu Ser Asp Lys Arg Lys Cys Ser Arg Ser Pro Lys Lys 
945                 950                 955                 960 


Ile Lys Ile Glu Pro Asp Ser Glu Lys Asp Glu Val Lys Gly Ser Asp 
                965                 970                 975     


Ala Ala Lys Gly Ala Asp Gln Asn Glu Met Asp Ile Ser Lys Ile Thr 
            980                 985                 990         


Glu Lys Lys Asp Gln Asp Val Lys  Glu Leu Leu Asp Ser  Asp Ser Asp 
        995                 1000                 1005             


Lys Pro  Cys Lys Glu Glu Pro  Met Glu Val Asp Asp  Asp Met Lys 
    1010                 1015                 1020             


Thr Glu  Ser His Val Asn Cys  Gln Glu Ser Ser Gln  Val Asp Val 
    1025                 1030                 1035             


Val Asn  Val Ser Glu Gly Phe  His Leu Arg Thr Ser  Tyr Lys Lys 
    1040                 1045                 1050             


Lys Thr  Lys Ser Ser Lys Leu  Asp Gly Leu Leu Glu  Arg Arg Ile 
    1055                 1060                 1065             


Lys Gln  Phe Thr Leu Glu Glu  Lys Gln Arg Leu Glu  Lys Ile Lys 
    1070                 1075                 1080             


Leu Glu  Gly Gly Ile Lys Gly  Ile Gly Lys Thr Ser  Thr Asn Ser 
    1085                 1090                 1095             


Ser Lys  Asn Leu Ser Glu Ser  Pro Val Ile Thr Lys  Ala Lys Glu 
    1100                 1105                 1110             


Gly Cys  Gln Ser Asp Ser Met  Arg Gln Glu Gln Ser  Pro Asn Ala 
    1115                 1120                 1125             


Asn Asn  Asp Gln Pro Glu Asp  Leu Ile Gln Gly Cys  Ser Glu Ser 
    1130                 1135                 1140             


Asp Ser  Ser Val Leu Arg Met  Ser Asp Pro Ser His  Thr Thr Asn 
    1145                 1150                 1155             


Lys Leu  Tyr Pro Lys Asp Arg  Val Leu Asp Asp Val  Ser Ile Arg 
    1160                 1165                 1170             


Ser Pro  Glu Thr Lys Cys Pro  Lys Gln Asn Ser Ile  Glu Asn Asp 
    1175                 1180                 1185             


Ile Glu  Glu Lys Val Ser Asp  Leu Ala Ser Arg Gly  Gln Glu Pro 
    1190                 1195                 1200             


Ser Lys  Ser Lys Thr Lys Gly  Asn Asp Phe Phe Ile  Asp Asp Ser 
    1205                 1210                 1215             


Lys Leu  Ala Ser Ala Asp Asp  Ile Gly Thr Leu Ile  Cys Lys Asn 
    1220                 1225                 1230             


Lys Lys  Pro Leu Ile Gln Glu  Glu Ser Asp Thr Ile  Val Ser Ser 
    1235                 1240                 1245             


Ser Lys  Ser Ala Leu His Ser  Ser Val Pro Lys Ser  Thr Asn Asp 
    1250                 1255                 1260             


Arg Asp  Ala Thr Pro Leu Ser  Arg Ala Met Asp Phe  Glu Gly Lys 
    1265                 1270                 1275             


Leu Gly  Cys Asp Ser Glu Ser  Asn Ser Thr Leu Glu  Asn Ser Ser 
    1280                 1285                 1290             


Asp Thr  Val Ser Ile Gln Asp  Ser Ser Glu Glu Asp  Met Ile Val 
    1295                 1300                 1305             


Gln Asn  Ser Asn Glu Ser Ile  Ser Glu Gln Phe Arg  Thr Arg Glu 
    1310                 1315                 1320             


Gln Asp  Val Glu Val Leu Glu  Pro Leu Lys Cys Glu  Leu Val Ser 
    1325                 1330                 1335             


Gly Glu  Ser Thr Gly Asn Cys  Glu Asp Arg Leu Pro  Val Lys Gly 
    1340                 1345                 1350             


Thr Glu  Ala Asn Gly Lys Lys  Pro Ser Gln Gln Lys  Lys Leu Glu 
    1355                 1360                 1365             


Glu Arg  Pro Val Asn Lys Cys  Ser Asp Gln Ile Lys  Leu Lys Asn 
    1370                 1375                 1380             


Thr Thr  Asp Lys Lys Asn Asn  Glu Asn Arg Glu Ser  Glu Lys Lys 
    1385                 1390                 1395             


Gly Gln  Arg Thr Ser Thr Phe  Gln Ile Asn Gly Lys  Asp Asn Lys 
    1400                 1405                 1410             


Pro Lys  Ile Tyr Leu Lys Gly  Glu Cys Leu Lys Glu  Ile Ser Glu 
    1415                 1420                 1425             


Ser Arg  Val Val Ser Gly Asn  Val Glu Pro Lys Val  Asn Asn Ile 
    1430                 1435                 1440             


Asn Lys  Ile Ile Pro Glu Asn  Asp Ile Lys Ser Leu  Thr Val Lys 
    1445                 1450                 1455             


Glu Ser  Ala Ile Arg Pro Phe  Ile Asn Gly Asp Val  Ile Met Glu 
    1460                 1465                 1470             


Asp Phe  Asn Glu Arg Asn Ser  Ser Glu Thr Lys Ser  His Leu Leu 
    1475                 1480                 1485             


Ser Ser  Ser Asp Ala Glu Gly  Asn Tyr Arg Asp Ser  Leu Glu Thr 
    1490                 1495                 1500             


Leu Pro  Ser Thr Lys Glu Ser  Asp Ser Thr Gln Thr  Thr Thr Pro 
    1505                 1510                 1515             


Ser Ala  Ser Cys Pro Glu Ser  Asn Ser Val Asn Gln  Val Glu Asp 
    1520                 1525                 1530             


Met Glu  Ile Glu Thr Ser Glu  Val Lys Lys Val Thr  Ser Ser Pro 
    1535                 1540                 1545             


Ile Thr  Ser Glu Glu Glu Ser  Asn Leu Ser Asn Asp  Phe Ile Asp 
    1550                 1555                 1560             


Glu Asn  Gly Leu Pro Ile Asn  Lys Asn Glu Asn Val  Asn Gly Glu 
    1565                 1570                 1575             


Ser Lys  Arg Lys Thr Val Ile  Thr Glu Val Thr Thr  Met Thr Ser 
    1580                 1585                 1590             


Thr Val  Ala Thr Glu Ser Lys  Thr Val Ile Lys Val  Glu Lys Gly 
    1595                 1600                 1605             


Asp Lys  Gln Thr Val Val Ser  Ser Thr Glu Asn Cys  Ala Lys Ser 
    1610                 1615                 1620             


Thr Val  Thr Thr Thr Thr Thr  Thr Val Thr Lys Leu  Ser Thr Pro 
    1625                 1630                 1635             


Ser Thr  Gly Gly Ser Val Asp  Ile Ile Ser Val Lys  Glu Gln Ser 
    1640                 1645                 1650             


Lys Thr  Val Val Thr Thr Thr  Val Thr Asp Ser Leu  Thr Thr Thr 
    1655                 1660                 1665             


Gly Gly  Thr Leu Val Thr Ser  Met Thr Val Ser Lys  Glu Tyr Ser 
    1670                 1675                 1680             


Thr Arg  Asp Lys Val Lys Leu  Met Lys Phe Ser Arg  Pro Lys Lys 
    1685                 1690                 1695             


Thr Arg  Ser Gly Thr Ala Leu  Pro Ser Tyr Arg Lys  Phe Val Thr 
    1700                 1705                 1710             


Lys Ser  Ser Lys Lys Ser Ile  Phe Val Leu Pro Asn  Asp Asp Leu 
    1715                 1720                 1725             


Lys Lys  Leu Ala Arg Lys Gly  Gly Ile Arg Glu Val  Pro Tyr Phe 
    1730                 1735                 1740             


Asn Tyr  Asn Ala Lys Pro Ala  Leu Asp Ile Trp Pro  Tyr Pro Ser 
    1745                 1750                 1755             


Pro Arg  Pro Thr Phe Gly Ile  Thr Trp Arg Tyr Arg  Leu Gln Thr 
    1760                 1765                 1770             


Val Lys  Ser Leu Ala Gly Val  Ser Leu Met Leu Arg  Leu Leu Trp 
    1775                 1780                 1785             


Ala Ser  Leu Arg Trp Asp Asp  Met Ala Ala Lys Ala  Pro Pro Gly 
    1790                 1795                 1800             


Gly Gly  Thr Thr Arg Thr Glu  Thr Ser Glu Thr Glu  Ile Thr Thr 
    1805                 1810                 1815             


Thr Glu  Ile Ile Lys Arg Arg  Asp Val Gly Pro Tyr  Gly Ile Arg 
    1820                 1825                 1830             


Ser Glu  Tyr Cys Ile Arg Lys  Ile Ile Cys Pro Ile  Gly Val Pro 
    1835                 1840                 1845             


Glu Thr  Pro Lys Glu Thr Pro  Thr Pro Gln Arg Lys  Gly Leu Arg 
    1850                 1855                 1860             


Ser Ser  Ala Leu Arg Pro Lys  Arg Pro Glu Thr Pro  Lys Gln Thr 
    1865                 1870                 1875             


Gly Pro  Val Ile Ile Glu Thr  Trp Val Ala Glu Glu  Glu Leu Glu 
    1880                 1885                 1890             


Leu Trp  Glu Ile Arg Ala Phe  Ala Glu Arg Val Glu  Lys Glu Lys 
    1895                 1900                 1905             


Ala Gln  Ala Val Glu Gln Gln  Ala Lys Lys Arg Leu  Glu Gln Gln 
    1910                 1915                 1920             


Lys Pro  Thr Val Ile Ala Thr  Ser Thr Thr Ser Pro  Thr Ser Ser 
    1925                 1930                 1935             


Thr Thr  Ser Thr Ile Ser Pro  Ala Gln Lys Val Met  Val Ala Pro 
    1940                 1945                 1950             


Ile Ser  Gly Ser Val Thr Thr  Gly Thr Lys Met Val  Leu Thr Thr 
    1955                 1960                 1965             


Lys Val  Gly Ser Pro Ala Thr  Val Thr Phe Gln Gln  Asn Lys Asn 
    1970                 1975                 1980             


Phe His  Gln Thr Phe Ala Thr  Trp Val Lys Gln Gly  Gln Ser Asn 
    1985                 1990                 1995             


Ser Gly  Val Val Gln Val Gln  Gln Lys Val Leu Gly  Ile Ile Pro 
    2000                 2005                 2010             


Ser Ser  Thr Gly Thr Ser Gln  Gln Thr Phe Thr Ser  Phe Gln Pro 
    2015                 2020                 2025             


Arg Thr  Ala Thr Val Thr Ile  Arg Pro Asn Thr Ser  Gly Ser Gly 
    2030                 2035                 2040             


Gly Thr  Thr Ser Asn Ser Gln  Val Ile Thr Gly Pro  Gln Ile Arg 
    2045                 2050                 2055             


Pro Gly  Met Thr Val Ile Arg  Thr Pro Leu Gln Gln  Ser Thr Leu 
    2060                 2065                 2070             


Gly Lys  Ala Ile Ile Arg Thr  Pro Val Met Val Gln  Pro Gly Ala 
    2075                 2080                 2085             


Pro Gln  Gln Val Met Thr Gln  Ile Ile Arg Gly Gln  Pro Val Ser 
    2090                 2095                 2100             


Thr Ala  Val Ser Ala Pro Asn  Thr Val Ser Ser Thr  Pro Gly Gln 
    2105                 2110                 2115             


Lys Ser  Leu Thr Ser Ala Thr  Ser Thr Ser Asn Ile  Gln Ser Ser 
    2120                 2125                 2130             


Ala Ser  Gln Pro Pro Arg Pro  Gln Gln Gly Gln Val  Lys Leu Thr 
    2135                 2140                 2145             


Met Ala  Gln Leu Thr Gln Leu  Thr Gln Gly His Gly  Gly Asn Gln 
    2150                 2155                 2160             


Gly Leu  Thr Val Val Ile Gln  Gly Gln Gly Gln Thr  Thr Gly Gln 
    2165                 2170                 2175             


Leu Gln  Leu Ile Pro Gln Gly  Val Thr Val Leu Pro  Gly Pro Gly 
    2180                 2185                 2190             


Gln Gln  Leu Met Gln Ala Ala  Met Pro Asn Gly Thr  Val Gln Arg 
    2195                 2200                 2205             


Phe Leu  Phe Thr Pro Leu Ala  Thr Thr Ala Thr Thr  Ala Ser Thr 
    2210                 2215                 2220             


Thr Thr  Thr Thr Val Ser Thr  Thr Ala Ala Gly Thr  Gly Glu Gln 
    2225                 2230                 2235             


Arg Gln  Ser Lys Leu Ser Pro  Gln Met Gln Val His  Gln Asp Lys 
    2240                 2245                 2250             


Thr Leu  Pro Pro Ala Gln Ser  Ser Ser Val Gly Pro  Ala Glu Ala 
    2255                 2260                 2265             


Gln Pro  Gln Thr Ala Gln Pro  Ser Ala Gln Pro Gln  Pro Gln Thr 
    2270                 2275                 2280             


Gln Pro  Gln Ser Pro Ala Gln  Pro Glu Val Gln Thr  Gln Pro Glu 
    2285                 2290                 2295             


Val Gln  Thr Gln Thr Thr Val  Ser Ser His Val Pro  Ser Glu Ala 
    2300                 2305                 2310             


Gln Pro  Thr His Ala Gln Ser  Ser Lys Pro Gln Val  Ala Ala Gln 
    2315                 2320                 2325             


Ser Gln  Pro Gln Ser Asn Val  Gln Gly Gln Ser Pro  Val Arg Val 
    2330                 2335                 2340             


Gln Ser  Pro Ser Gln Thr Arg  Ile Arg Pro Ser Thr  Pro Ser Gln 
    2345                 2350                 2355             


Leu Ser  Pro Gly Gln Gln Ser  Gln Val Gln Thr Thr  Thr Ser Gln 
    2360                 2365                 2370             


Pro Ile  Pro Ile Gln Pro His  Thr Ser Leu Gln Ile  Pro Ser Gln 
    2375                 2380                 2385             


Gly Gln  Pro Gln Ser Gln Pro  Gln Val Gln Ser Ser  Thr Gln Thr 
    2390                 2395                 2400             


Leu Ser  Ser Gly Gln Thr Leu  Asn Gln Val Thr Val  Ser Ser Pro 
    2405                 2410                 2415             


Ser Arg  Pro Gln Leu Gln Ile  Gln Gln Pro Gln Pro  Gln Val Ile 
    2420                 2425                 2430             


Ala Val  Pro Gln Leu Gln Gln  Gln Val Gln Val Leu  Ser Gln Ile 
    2435                 2440                 2445             


Gln Ser  Gln Val Val Ala Gln  Ile Gln Ala Gln Gln  Ser Gly Val 
    2450                 2455                 2460             


Pro Gln  Gln Ile Lys Leu Gln  Leu Pro Ile Gln Ile  Gln Gln Ser 
    2465                 2470                 2475             


Ser Ala  Val Gln Thr His Gln  Ile Gln Asn Val Val  Thr Val Gln 
    2480                 2485                 2490             


Ala Ala  Ser Val Gln Glu Gln  Leu Gln Arg Val Gln  Gln Leu Arg 
    2495                 2500                 2505             


Asp Gln  Gln Gln Lys Lys Lys  Gln Gln Gln Ile Glu  Ile Lys Arg 
    2510                 2515                 2520             


Glu His  Thr Leu Gln Ala Ser  Asn Gln Ser Glu Ile  Ile Gln Lys 
    2525                 2530                 2535             


Gln Val  Val Met Lys His Asn  Ala Val Ile Glu His  Leu Lys Gln 
    2540                 2545                 2550             


Lys Lys  Ser Met Thr Pro Ala  Glu Arg Glu Glu Asn  Gln Arg Met 
    2555                 2560                 2565             


Ile Val  Cys Asn Gln Val Met  Lys Tyr Ile Leu Asp  Lys Ile Asp 
    2570                 2575                 2580             


Lys Glu  Glu Lys Gln Ala Ala  Lys Lys Arg Lys Arg  Glu Glu Ser 
    2585                 2590                 2595             


Val Glu  Gln Lys Arg Ser Lys  Gln Asn Ala Thr Lys  Leu Ser Ala 
    2600                 2605                 2610             


Leu Leu  Phe Lys His Lys Glu  Gln Leu Arg Ala Glu  Ile Leu Lys 
    2615                 2620                 2625             


Lys Arg  Ala Leu Leu Asp Lys  Asp Leu Gln Ile Glu  Val Gln Glu 
    2630                 2635                 2640             


Glu Leu  Lys Arg Asp Leu Lys  Ile Lys Lys Glu Lys  Asp Leu Met 
    2645                 2650                 2655             


Gln Leu  Ala Gln Ala Thr Ala  Val Ala Ala Pro Cys  Pro Pro Val 
    2660                 2665                 2670             


Thr Pro  Ala Pro Pro Ala Pro  Pro Ala Pro Pro Pro  Ser Pro Pro 
    2675                 2680                 2685             


Pro Pro  Pro Ala Val Gln His  Thr Gly Leu Leu Ser  Thr Pro Thr 
    2690                 2695                 2700             


Leu Pro  Ala Ala Ser Gln Lys  Arg Lys Arg Glu Glu  Glu Lys Asp 
    2705                 2710                 2715             


Ser Ser  Ser Lys Ser Lys Lys  Lys Lys Met Ile Ser  Thr Thr Ser 
    2720                 2725                 2730             


Lys Glu  Thr Lys Lys Asp Thr  Lys Leu Tyr Cys Ile  Cys Lys Thr 
    2735                 2740                 2745             


Pro Tyr  Asp Glu Ser Lys Phe  Tyr Ile Gly Cys Asp  Arg Cys Gln 
    2750                 2755                 2760             


Asn Trp  Tyr His Gly Arg Cys  Val Gly Ile Leu Gln  Ser Glu Ala 
    2765                 2770                 2775             


Glu Leu  Ile Asp Glu Tyr Val  Cys Pro Gln Cys Gln  Ser Thr Glu 
    2780                 2785                 2790             


Asp Ala  Met Thr Val Leu Thr  Pro Leu Thr Glu Lys  Asp Tyr Glu 
    2795                 2800                 2805             


Gly Leu  Lys Arg Val Leu Arg  Ser Leu Gln Ala His  Lys Met Ala 
    2810                 2815                 2820             


Trp Pro  Phe Leu Glu Pro Val  Asp Pro Asn Asp Ala  Pro Asp Tyr 
    2825                 2830                 2835             


Tyr Gly  Val Ile Lys Glu Pro  Met Asp Leu Ala Thr  Met Glu Glu 
    2840                 2845                 2850             


Arg Val  Gln Arg Arg Tyr Tyr  Glu Lys Leu Thr Glu  Phe Val Ala 
    2855                 2860                 2865             


Asp Met  Thr Lys Ile Phe Asp  Asn Cys Arg Tyr Tyr  Asn Pro Ser 
    2870                 2875                 2880             


Asp Ser  Pro Phe Tyr Gln Cys  Ala Glu Val Leu Glu  Ser Phe Phe 
    2885                 2890                 2895             


Val Gln  Lys Leu Lys Gly Phe  Lys Ala Ser Arg Ser  His Asn Asn 
    2900                 2905                 2910             


Lys Leu  Gln Ser Thr Ala Ser  
    2915                 2920 


<210> 5268
<211> 129
<212> PRT
<213> Homo sapiens

<400> 5268
Met Ala Asp Pro Arg Val Arg Gln Ile Lys Ile Lys Thr Gly Val Val 
1               5                   10                  15      


Lys Arg Leu Val Lys Glu Lys Val Met Tyr Glu Lys Glu Ala Lys Gln 
            20                  25                  30          


Gln Glu Glu Lys Ile Glu Lys Met Arg Ala Glu Asp Gly Glu Asn Tyr 
        35                  40                  45              


Asp Ile Lys Lys Gln Ala Glu Ile Leu Gln Glu Ser Arg Met Met Ile 
    50                  55                  60                  


Pro Asp Cys Gln Arg Arg Leu Glu Ala Ala Tyr Leu Asp Leu Gln Arg 
65                  70                  75                  80  


Ile Leu Val Ser Lys Asp Phe Cys Val Met Phe Lys Phe Phe Phe Ser 
                85                  90                  95      


Ile Gln Tyr Met Glu Ser Gln Lys Phe Lys Tyr Leu Thr Leu Arg Thr 
            100                 105                 110         


Ser Trp Gln Tyr Phe Leu Phe Thr Cys Pro Leu Tyr Arg Tyr Ile Leu 
        115                 120                 125             


Lys 
    


<210> 5269
<211> 193
<212> PRT
<213> Homo sapiens

<400> 5269
Met Ser Asp Asp Asp Ser Arg Ala Ser Thr Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Asn Gln Gln Thr Glu Lys Glu Thr Asn Thr Pro Lys Lys Lys 
            20                  25                  30          


Glu Ser Lys Val Ser Met Ser Lys Asn Ser Lys Leu Leu Ser Thr Ser 
        35                  40                  45              


Ala Lys Arg Ile Gln Lys Glu Leu Ala Asp Ile Thr Leu Asp Pro Pro 
    50                  55                  60                  


Pro Asn Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg 
65                  70                  75                  80  


Ser Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe 
                85                  90                  95      


Phe Leu Asp Ile Thr Phe Thr Pro Glu Tyr Pro Phe Lys Pro Pro Lys 
            100                 105                 110         


Val Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly 
        115                 120                 125             


Val Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr 
    130                 135                 140                 


Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn 
145                 150                 155                 160 


Pro Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn 
                165                 170                 175     


Arg Ala Glu His Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala 
            180                 185                 190         


Thr 
    


<210> 5270
<211> 464
<212> PRT
<213> Homo sapiens

<400> 5270
Met Ser Leu Gln Phe Ser Asn Gly Ser Arg His Val Cys Leu Arg Ser 
1               5                   10                  15      


Gly Ala Gly Ser Val Arg Pro Leu Asn Gly Gly Ala Gly Phe Ala Gly 
            20                  25                  30          


Ser Ser Ala Cys Gly Gly Ser Val Ala Gly Ser Glu Phe Ser Cys Ala 
        35                  40                  45              


Leu Gly Gly Gly Leu Gly Ser Val Pro Gly Gly Ser His Ala Gly Gly 
    50                  55                  60                  


Ala Leu Gly Asn Ala Ala Cys Ile Gly Phe Ala Gly Ser Glu Gly Gly 
65                  70                  75                  80  


Leu Leu Ser Gly Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg 
                85                  90                  95      


Leu Ala Ser Tyr Leu Asp Asn Val Arg Ala Leu Glu Glu Ala Asn Ala 
            100                 105                 110         


Glu Leu Glu Arg Lys Ile Lys Gly Trp Tyr Glu Lys Tyr Gly Pro Gly 
        115                 120                 125             


Ser Cys Arg Gly Leu Asp His Asp Tyr Ser Arg Tyr His Leu Thr Ile 
    130                 135                 140                 


Glu Asp Leu Lys Asn Lys Ile Ile Ser Ser Thr Thr Thr Asn Ala Asn 
145                 150                 155                 160 


Val Ile Leu Gln Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg 
                165                 170                 175     


Leu Lys Tyr Glu Asn Glu Leu Thr Leu His Gln Asn Val Glu Ala Asp 
            180                 185                 190         


Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Cys Arg Thr 
        195                 200                 205             


Asp Gln Glu Leu Gln Tyr Glu Ser Leu Ser Glu Glu Met Thr Tyr Leu 
    210                 215                 220                 


Lys Lys Asn His Glu Glu Glu Met Lys Ala Leu Gln Cys Ala Ala Gly 
225                 230                 235                 240 


Gly Asn Val Asn Val Glu Met Asn Ala Ala Pro Gly Val Asp Leu Ala 
                245                 250                 255     


Val Leu Leu Asn Asn Met Arg Ala Glu Tyr Glu Ala Leu Ala Glu Gln 
            260                 265                 270         


Asn Arg Lys Asp Ala Glu Ala Trp Phe Asn Glu Lys Ser Ala Ser Leu 
        275                 280                 285             


Gln Gln Gln Ile Ser His Asp Ser Gly Ala Ala Thr Phe Ala Arg Ser 
    290                 295                 300                 


Gln Leu Thr Glu Met Arg Arg Thr Leu Gln Thr Leu Glu Ile Gln Leu 
305                 310                 315                 320 


Gln Ser Leu Met Ala Thr Lys His Ser Leu Glu Cys Ser Leu Thr Glu 
                325                 330                 335     


Thr Glu Ser Asn Tyr Cys Thr Gln Leu Ala Gln Ile Gln Ala Gln Ile 
            340                 345                 350         


Gly Ala Leu Glu Glu Gln Leu His Gln Val Arg Thr Glu Thr Glu Gly 
        355                 360                 365             


Gln Lys Leu Glu Tyr Glu His Leu Leu Asp Val Lys Val His Leu Glu 
    370                 375                 380                 


Lys Glu Ile Glu Thr Tyr Cys Arg Leu Ile Asp Gly Asp Gly Asn Ser 
385                 390                 395                 400 


Cys Ser Lys Ser Lys Gly Phe Gly Ser Gly Ser Pro Gly Asn Ser Ser 
                405                 410                 415     


Lys Asp Leu Ser Lys Thr Thr Leu Val Lys Thr Val Val Glu Glu Leu 
            420                 425                 430         


Asp Gln Arg Gly Lys Val Leu Ser Ser Arg Ile His Ser Ile Glu Glu 
        435                 440                 445             


Lys Thr Ser Lys Met Thr Asn Gly Lys Thr Glu Gln Arg Val Pro Phe 
    450                 455                 460                 


<210> 5271
<211> 670
<212> PRT
<213> Homo sapiens

<400> 5271
Met Glu Glu Phe Arg Arg Ser Tyr Ser Arg Leu Cys Arg Glu Ser Gly 
1               5                   10                  15      


Ala Glu Pro Gln Glu Ala Val Leu Gln Gln Leu His Gln Leu Pro Arg 
            20                  25                  30          


Gly Arg Leu Asp Leu Ala Thr Gln Ser Leu Thr Val Glu Thr Cys Arg 
        35                  40                  45              


Ala Leu Gly Lys Leu Leu Pro Arg Glu Thr Leu Cys Thr Glu Leu Val 
    50                  55                  60                  


Leu Ser Asp Cys Met Leu Ser Glu Glu Gly Ala Thr Leu Leu Leu Arg 
65                  70                  75                  80  


Gly Leu Cys Ala Asn Thr Val Leu Arg Phe Leu Asp Leu Lys Gly Asn 
                85                  90                  95      


Asn Leu Arg Ala Ala Gly Ala Glu Ala Leu Gly Lys Leu Leu Gln Gln 
            100                 105                 110         


Asn Lys Ser Ile Gln Ser Leu Thr Leu Glu Trp Asn Ser Leu Gly Thr 
        115                 120                 125             


Trp Asp Asp Ala Phe Ala Thr Phe Cys Gly Gly Leu Ala Ala Asn Gly 
    130                 135                 140                 


Ala Leu Gln Arg Leu Asp Leu Arg Asn Asn Gln Ile Ser His Lys Gly 
145                 150                 155                 160 


Ala Glu Glu Leu Ala Leu Ala Leu Lys Gly Asn Thr Thr Leu Gln Gln 
                165                 170                 175     


Leu Asp Leu Arg Trp Asn Asn Val Gly Leu Leu Gly Gly Arg Ala Leu 
            180                 185                 190         


Met Asn Cys Leu Pro Ser Asn Arg Thr Leu Trp Arg Leu Asp Leu Ala 
        195                 200                 205             


Gly Asn Asn Ile Pro Gly Asp Val Leu Arg Ala Val Glu Gln Ala Met 
    210                 215                 220                 


Gly His Ser Gln Asp Arg Leu Thr Thr Phe Gln Glu Asn Gln Ala Arg 
225                 230                 235                 240 


Thr His Val Leu Ser Lys Glu Val Gln His Leu Arg Glu Glu Lys Ser 
                245                 250                 255     


Lys Gln Phe Leu Asp Leu Met Glu Thr Ile Asp Lys Gln Arg Glu Glu 
            260                 265                 270         


Met Ala Lys Ser Ser Arg Ala Ser Ala Ala Arg Val Gly Gln Leu Gln 
        275                 280                 285             


Glu Ala Leu Asn Glu Arg His Ser Ile Ile Asn Ala Leu Lys Ala Lys 
    290                 295                 300                 


Leu Gln Met Thr Glu Ala Ala Leu Ala Leu Ser Glu Gln Lys Ala Gln 
305                 310                 315                 320 


Asp Leu Gly Glu Leu Leu Ala Thr Ala Glu Gln Glu Gln Leu Ser Leu 
                325                 330                 335     


Ser Gln Arg Gln Ala Lys Glu Leu Lys Leu Glu Gln Gln Glu Ala Ala 
            340                 345                 350         


Glu Arg Glu Ser Lys Leu Leu Arg Asp Leu Ser Ala Ala Asn Glu Lys 
        355                 360                 365             


Asn Leu Leu Leu Gln Asn Gln Val Asp Glu Leu Glu Arg Lys Phe Arg 
    370                 375                 380                 


Cys Gln Gln Glu Gln Leu Phe Gln Thr Arg Gln Glu Met Thr Ser Met 
385                 390                 395                 400 


Ser Ala Glu Leu Lys Met Arg Ala Ile Gln Ala Glu Glu Arg Leu Asp 
                405                 410                 415     


Met Glu Lys Arg Arg Cys Arg Gln Ser Leu Glu Asp Ser Glu Ser Leu 
            420                 425                 430         


Arg Ile Lys Glu Val Glu His Met Thr Arg His Leu Glu Glu Ser Glu 
        435                 440                 445             


Lys Ala Met Gln Glu Arg Val Gln Arg Leu Glu Ala Ala Arg Leu Ser 
    450                 455                 460                 


Leu Glu Glu Glu Leu Ser Arg Val Lys Ala Ala Ala Leu Ser Glu Arg 
465                 470                 475                 480 


Gly Gln Ala Glu Glu Glu Leu Ile Lys Ala Lys Ser Gln Ala Arg Leu 
                485                 490                 495     


Glu Glu Gln Gln Arg Leu Ala His Leu Glu Asp Lys Leu Arg Leu Leu 
            500                 505                 510         


Ala Gln Ala Arg Asp Glu Ala Gln Gly Ala Cys Leu Gln Gln Lys Gln 
        515                 520                 525             


Val Val Ala Glu Ala Gln Thr Arg Val Ser Gln Leu Gly Leu Gln Val 
    530                 535                 540                 


Glu Gly Leu Arg Arg Arg Leu Glu Glu Leu Gln Gln Glu Leu Ser Leu 
545                 550                 555                 560 


Lys Asp Gln Glu Arg Val Ala Glu Val Ser Arg Val Arg Val Glu Leu 
                565                 570                 575     


Gln Glu Gln Asn Gly Arg Leu Gln Ala Glu Leu Ala Ala Gln Glu Ala 
            580                 585                 590         


Leu Arg Glu Lys Ala Ala Ala Leu Glu Arg Gln Leu Lys Val Met Ala 
        595                 600                 605             


Ser Asp His Arg Glu Ala Leu Leu Asp Arg Glu Ser Glu Asn Ala Ser 
    610                 615                 620                 


Leu Arg Glu Lys Leu Arg Leu Arg Glu Ala Glu Ile Ala Arg Ile Arg 
625                 630                 635                 640 


Asp Glu Glu Ala Gln Arg Ala Ser Phe Leu Gln Asn Ala Val Leu Ala 
                645                 650                 655     


Tyr Val Gln Ala Ser Pro Val Arg Thr Leu Ser Pro Pro Lys 
            660                 665                 670 


<210> 5272
<211> 593
<212> PRT
<213> Homo sapiens

<400> 5272
Met Glu Pro Ala Thr Ala Pro Arg Pro Asp Met Ala Pro Glu Leu Thr 
1               5                   10                  15      


Pro Glu Glu Glu Gln Ala Thr Lys Gln Phe Leu Glu Glu Ile Asn Lys 
            20                  25                  30          


Trp Thr Val Gln Tyr Asn Val Ser Pro Leu Ser Trp Asn Val Ala Val 
        35                  40                  45              


Lys Phe Leu Met Ala Arg Lys Phe Asp Val Leu Arg Ala Ile Glu Leu 
    50                  55                  60                  


Phe His Ser Tyr Arg Glu Thr Arg Arg Lys Glu Gly Ile Val Lys Leu 
65                  70                  75                  80  


Lys Pro His Glu Glu Pro Leu Arg Ser Glu Ile Leu Ser Gly Lys Phe 
                85                  90                  95      


Thr Ile Leu Asn Val Arg Asp Pro Thr Gly Ala Ser Ile Ala Leu Phe 
            100                 105                 110         


Thr Ala Arg Leu His His Pro His Lys Ser Val Gln His Val Val Leu 
        115                 120                 125             


Gln Ala Leu Phe Tyr Leu Leu Asp Arg Ala Val Asp Ser Phe Glu Thr 
    130                 135                 140                 


Gln Arg Asn Gly Leu Val Phe Ile Tyr Asp Met Cys Gly Ser Asn Tyr 
145                 150                 155                 160 


Ala Asn Phe Glu Leu Asp Leu Gly Lys Lys Val Leu Asn Leu Leu Lys 
                165                 170                 175     


Gly Ala Phe Pro Ala Arg Leu Lys Lys Val Leu Ile Val Gly Ala Pro 
            180                 185                 190         


Ile Trp Phe Arg Val Pro Tyr Ser Ile Ile Ser Leu Leu Leu Lys Asp 
        195                 200                 205             


Lys Val Arg Glu Arg Ile Gln Ile Leu Lys Thr Ser Glu Val Thr Gln 
    210                 215                 220                 


His Leu Pro Arg Glu Cys Leu Pro Glu Asn Leu Gly Gly Tyr Val Lys 
225                 230                 235                 240 


Ile Asp Leu Ala Thr Trp Asn Phe Gln Phe Leu Pro Gln Val Asn Gly 
                245                 250                 255     


His Pro Asp Pro Phe Asp Glu Ile Ile Leu Phe Ser Leu Pro Pro Ala 
            260                 265                 270         


Leu Asp Trp Asp Ser Val His Val Pro Gly Pro His Ala Met Thr Ile 
        275                 280                 285             


Gln Glu Leu Val Asp Tyr Val Asn Ala Arg Gln Lys Gln Gly Ile Tyr 
    290                 295                 300                 


Glu Glu Tyr Glu Asp Ile Arg Arg Glu Asn Pro Val Gly Thr Phe His 
305                 310                 315                 320 


Cys Ser Met Ser Pro Gly Asn Leu Glu Lys Asn Arg Tyr Gly Asp Val 
                325                 330                 335     


Pro Cys Leu Asp Gln Thr Arg Val Lys Leu Thr Lys Arg Ser Gly His 
            340                 345                 350         


Thr Gln Thr Asp Tyr Ile Asn Ala Ser Phe Met Asp Gly Tyr Lys Gln 
        355                 360                 365             


Lys Asn Ala Tyr Ile Gly Thr Gln Gly Pro Leu Glu Asn Thr Tyr Arg 
    370                 375                 380                 


Asp Phe Trp Leu Met Val Trp Glu Gln Lys Val Leu Val Ile Val Met 
385                 390                 395                 400 


Thr Thr Arg Phe Glu Glu Gly Gly Arg Arg Lys Cys Gly Gln Tyr Trp 
                405                 410                 415     


Pro Leu Glu Lys Asp Ser Arg Ile Arg Phe Gly Phe Leu Thr Val Thr 
            420                 425                 430         


Asn Leu Gly Val Glu Asn Met Asn His Tyr Lys Lys Thr Thr Leu Glu 
        435                 440                 445             


Ile His Asn Thr Glu Glu Arg Gln Lys Arg Gln Val Thr His Phe Gln 
    450                 455                 460                 


Phe Leu Ser Trp Pro Asp Tyr Gly Val Pro Ser Ser Ala Ala Ser Leu 
465                 470                 475                 480 


Ile Asp Phe Leu Arg Val Val Arg Asn Gln Gln Ser Leu Ala Val Ser 
                485                 490                 495     


Asn Met Gly Ala Arg Ser Lys Gly Gln Cys Pro Glu Pro Pro Ile Val 
            500                 505                 510         


Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Phe Cys Ser Leu 
        515                 520                 525             


Asp Ile Cys Leu Ala Gln Leu Glu Glu Leu Gly Thr Leu Asn Val Phe 
    530                 535                 540                 


Gln Thr Val Ser Arg Met Arg Thr Gln Arg Ala Phe Ser Ile Gln Thr 
545                 550                 555                 560 


Pro Glu Gln Tyr Tyr Phe Cys Tyr Lys Ala Ile Leu Glu Phe Ala Glu 
                565                 570                 575     


Lys Glu Gly Met Val Ser Ser Gly Gln Asn Leu Leu Ala Val Glu Ser 
            580                 585                 590         


Gln 
    


<210> 5273
<211> 627
<212> PRT
<213> Homo sapiens

<400> 5273
Met Glu Gly Leu Ala Gly Tyr Val Tyr Lys Ala Ala Ser Glu Gly Lys 
1               5                   10                  15      


Val Leu Thr Leu Ala Ala Leu Leu Leu Asn Arg Ser Glu Ser Asp Ile 
            20                  25                  30          


Arg Tyr Leu Leu Gly Tyr Val Ser Gln Gln Gly Gly Gln Arg Ser Thr 
        35                  40                  45              


Pro Leu Ile Ile Ala Ala Arg Asn Gly His Ala Lys Val Val Arg Leu 
    50                  55                  60                  


Leu Leu Glu His Tyr Arg Val Gln Thr Gln Gln Thr Gly Thr Val Arg 
65                  70                  75                  80  


Phe Asp Gly Tyr Val Ile Asp Gly Ala Thr Ala Leu Trp Cys Ala Ala 
                85                  90                  95      


Gly Ala Gly His Phe Glu Val Val Lys Leu Leu Val Ser His Gly Ala 
            100                 105                 110         


Asn Val Asn His Thr Thr Val Thr Asn Ser Thr Pro Leu Arg Ala Ala 
        115                 120                 125             


Cys Phe Asp Gly Arg Leu Asp Ile Val Lys Tyr Leu Val Glu Asn Asn 
    130                 135                 140                 


Ala Asn Ile Ser Ile Ala Asn Lys Tyr Asp Asn Thr Cys Leu Met Ile 
145                 150                 155                 160 


Ala Ala Tyr Lys Gly His Thr Asp Val Val Arg Tyr Leu Leu Glu Gln 
                165                 170                 175     


Arg Ala Asp Pro Asn Ala Lys Ala His Cys Gly Ala Thr Ala Leu His 
            180                 185                 190         


Phe Ala Ala Glu Ala Gly His Ile Asp Ile Val Lys Glu Leu Ile Lys 
        195                 200                 205             


Trp Arg Ala Ala Ile Val Val Asn Gly His Gly Met Thr Pro Leu Lys 
    210                 215                 220                 


Val Ala Ala Glu Ser Cys Lys Ala Asp Val Val Glu Leu Leu Leu Ser 
225                 230                 235                 240 


His Ala Asp Cys Asp Arg Arg Ser Arg Ile Glu Ala Leu Glu Leu Leu 
                245                 250                 255     


Gly Ala Ser Phe Ala Asn Asp Arg Glu Asn Tyr Asp Ile Ile Lys Thr 
            260                 265                 270         


Tyr His Tyr Leu Tyr Leu Ala Met Leu Glu Arg Phe Gln Asp Gly Asp 
        275                 280                 285             


Asn Ile Leu Glu Lys Glu Val Leu Pro Pro Ile His Ala Tyr Gly Asn 
    290                 295                 300                 


Arg Thr Glu Cys Arg Asn Pro Gln Glu Leu Glu Ser Ile Arg Gln Asp 
305                 310                 315                 320 


Arg Asp Ala Leu His Met Glu Gly Leu Ile Val Arg Glu Arg Ile Leu 
                325                 330                 335     


Gly Ala Asp Asn Ile Asp Val Ser His Pro Ile Ile Tyr Arg Gly Ala 
            340                 345                 350         


Val Tyr Ala Asp Asn Met Glu Phe Glu Gln Cys Ile Lys Leu Trp Leu 
        355                 360                 365             


His Ala Leu His Leu Arg Gln Lys Gly Asn Arg Asn Thr His Lys Asp 
    370                 375                 380                 


Leu Leu Arg Phe Ala Gln Val Phe Ser Gln Met Ile His Leu Asn Glu 
385                 390                 395                 400 


Thr Val Lys Ala Pro Asp Ile Glu Cys Val Leu Arg Cys Ser Val Leu 
                405                 410                 415     


Glu Ile Glu Gln Ser Met Asn Arg Val Lys Asn Ile Ser Asp Ala Asp 
            420                 425                 430         


Val His Asn Ala Met Asp Asn Tyr Glu Cys Asn Leu Tyr Thr Phe Leu 
        435                 440                 445             


Tyr Leu Val Cys Ile Ser Thr Lys Thr Gln Cys Ser Glu Glu Asp Gln 
    450                 455                 460                 


Cys Lys Ile Asn Lys Gln Ile Tyr Asn Leu Ile His Leu Asp Pro Arg 
465                 470                 475                 480 


Thr Arg Glu Gly Phe Thr Leu Leu His Leu Ala Val Asn Ser Asn Thr 
                485                 490                 495     


Pro Val Asp Asp Phe His Thr Asn Asp Val Cys Ser Phe Pro Asn Ala 
            500                 505                 510         


Leu Val Thr Lys Leu Leu Leu Asp Cys Gly Ala Glu Val Asn Ala Val 
        515                 520                 525             


Asp Asn Glu Gly Asn Ser Ala Leu His Ile Ile Val Gln Tyr Asn Arg 
    530                 535                 540                 


Pro Ile Ser Asp Phe Leu Thr Leu His Ser Ile Ile Ile Ser Leu Val 
545                 550                 555                 560 


Glu Ala Gly Ala His Thr Asp Met Thr Asn Lys Gln Asn Lys Thr Pro 
                565                 570                 575     


Leu Asp Lys Ser Thr Thr Gly Val Ser Glu Ile Leu Leu Lys Thr Gln 
            580                 585                 590         


Met Lys Met Ser Leu Lys Cys Leu Ala Ala Arg Ala Val Arg Ala Asn 
        595                 600                 605             


Asp Ile Asn Tyr Gln Asp Gln Ile Pro Arg Thr Leu Glu Glu Phe Val 
    610                 615                 620                 


Gly Phe His 
625         


<210> 5274
<211> 125
<212> PRT
<213> Homo sapiens

<400> 5274
Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 
1               5                   10                  15      


Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                85                  90                  95      


Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Cys Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 
        115                 120                 125 


<210> 5275
<211> 1261
<212> PRT
<213> Homo sapiens

<400> 5275
Met Gly Thr Gly Asp Phe Ile Cys Ile Ser Met Thr Gly Gly Ala Pro 
1               5                   10                  15      


Trp Gly Phe Arg Leu Gln Gly Gly Lys Glu Gln Lys Gln Pro Leu Gln 
            20                  25                  30          


Val Ala Lys Ile Arg Asn Gln Ser Lys Ala Ser Gly Ser Gly Leu Cys 
        35                  40                  45              


Glu Gly Asp Glu Val Val Ser Ile Asn Gly Asn Pro Cys Ala Asp Leu 
    50                  55                  60                  


Thr Tyr Pro Glu Val Ile Lys Leu Met Glu Ser Ile Thr Asp Ser Leu 
65                  70                  75                  80  


Gln Met Leu Ile Lys Arg Pro Ser Ser Gly Ile Ser Glu Ala Leu Ile 
                85                  90                  95      


Ser Glu Asn Glu Asn Lys Asn Leu Glu His Leu Thr His Gly Gly Tyr 
            100                 105                 110         


Val Glu Ser Thr Thr Leu Gln Ile Arg Pro Ala Thr Lys Thr Gln Cys 
        115                 120                 125             


Thr Glu Phe Phe Leu Ala Pro Val Lys Thr Glu Val Pro Leu Ala Glu 
    130                 135                 140                 


Asn Gln Arg Ser Gly Pro Asp Cys Ala Gly Ser Leu Lys Glu Glu Thr 
145                 150                 155                 160 


Gly Pro Ser Tyr Gln Arg Ala Pro Gln Met Pro Asp Ser Gln Arg Gly 
                165                 170                 175     


Arg Val Ala Glu Glu Leu Ile Leu Arg Glu Lys Val Glu Ala Val Gln 
            180                 185                 190         


Pro Gly Pro Val Val Glu Leu Gln Leu Ser Leu Ser Gln Glu Arg His 
        195                 200                 205             


Lys Gly Ala Ser Gly Pro Leu Val Ala Leu Pro Gly Ala Glu Lys Ser 
    210                 215                 220                 


Lys Ser Pro Asp Pro Asp Pro Asn Leu Ser His Asp Arg Ile Val His 
225                 230                 235                 240 


Ile Asn Ser Ile Pro Thr Asn Glu Lys Ala Asp Pro Phe Leu Arg Ser 
                245                 250                 255     


Ser Lys Ile Ile Gln Ile Ser Ser Gly Arg Glu Leu Arg Val Ile Gln 
            260                 265                 270         


Glu Ser Glu Ala Gly Asp Ala Gly Leu Pro Arg Val Glu Val Ile Leu 
        275                 280                 285             


Asp Cys Ser Asp Arg Gln Lys Thr Glu Gly Cys Arg Leu Gln Ala Gly 
    290                 295                 300                 


Lys Glu Cys Val Asp Ser Pro Val Glu Gly Gly Gln Ser Glu Ala Pro 
305                 310                 315                 320 


Pro Ser Leu Val Ser Phe Ala Val Ser Ser Glu Gly Thr Glu Gln Gly 
                325                 330                 335     


Glu Asp Pro Arg Ser Glu Lys Asp His Ser Arg Pro His Lys His Arg 
            340                 345                 350         


Ala Arg His Ala Arg Leu Arg Arg Ser Glu Ser Leu Ser Glu Lys Gln 
        355                 360                 365             


Val Lys Glu Ala Lys Ser Lys Cys Lys Ser Ile Ala Leu Leu Leu Thr 
    370                 375                 380                 


Asp Ala Pro Asn Pro Asn Ser Lys Gly Val Leu Met Phe Lys Lys Arg 
385                 390                 395                 400 


Arg Arg Arg Ala Arg Lys Tyr Thr Leu Val Ser Tyr Gly Thr Gly Glu 
                405                 410                 415     


Leu Glu Arg Glu Ala Asp Glu Glu Glu Glu Gly Asp Lys Glu Asp Thr 
            420                 425                 430         


Cys Glu Val Ala Phe Leu Gly Ala Ser Glu Ser Glu Val Asp Glu Glu 
        435                 440                 445             


Leu Leu Ser Asp Val Asp Asp Asn Thr Gln Val Val Asn Phe Asp Trp 
    450                 455                 460                 


Asp Ser Gly Leu Val Asp Ile Glu Lys Lys Leu Asn Arg Gly Asp Lys 
465                 470                 475                 480 


Met Glu Met Leu Pro Asp Thr Thr Gly Lys Gly Ala Leu Met Phe Ala 
                485                 490                 495     


Lys Arg Arg Glu Arg Met Asp Gln Ile Thr Ala Gln Lys Glu Glu Asp 
            500                 505                 510         


Lys Val Gly Gly Thr Pro Ser Arg Glu Gln Asp Ala Ala Gln Thr Asp 
        515                 520                 525             


Gly Leu Arg Thr Thr Thr Ser Tyr Gln Arg Lys Glu Glu Glu Ser Val 
    530                 535                 540                 


Arg Thr Gln Ser Ser Val Ser Lys Ser Tyr Ile Glu Val Ser His Gly 
545                 550                 555                 560 


Leu Gly His Val Pro Gln Gln Asn Gly Phe Ser Gly Thr Ser Glu Thr 
                565                 570                 575     


Ala Asn Ile Gln Arg Met Val Pro Met Asn Arg Thr Ala Lys Pro Phe 
            580                 585                 590         


Pro Gly Ser Val Asn Gln Pro Ala Thr Pro Phe Ser Pro Thr Arg Asn 
        595                 600                 605             


Met Thr Ser Pro Ile Ala Asp Phe Pro Ala Pro Pro Pro Tyr Ser Ala 
    610                 615                 620                 


Val Thr Pro Pro Pro Asp Ala Phe Ser Arg Gly Val Ser Ser Pro Ile 
625                 630                 635                 640 


Ala Gly Pro Ala Gln Pro Pro Pro Trp Pro Gln Pro Ala Pro Trp Ser 
                645                 650                 655     


Gln Pro Ala Phe Tyr Asp Ser Ser Glu Arg Ile Ala Ser Arg Asp Glu 
            660                 665                 670         


Arg Ile Ser Val Pro Ala Lys Arg Thr Gly Ile Leu Gln Glu Ala Lys 
        675                 680                 685             


Arg Arg Ser Thr Thr Lys Pro Met Phe Thr Phe Lys Glu Pro Lys Val 
    690                 695                 700                 


Ser Pro Asn Pro Glu Leu Leu Ser Leu Leu Gln Asn Ser Glu Gly Lys 
705                 710                 715                 720 


Arg Gly Thr Gly Ala Gly Gly Asp Ser Gly Pro Glu Glu Asp Tyr Leu 
                725                 730                 735     


Ser Leu Gly Ala Glu Ala Cys Asn Phe Met Gln Ser Ser Ser Ala Lys 
            740                 745                 750         


Gln Lys Thr Pro Pro Pro Val Ala Pro Lys Pro Ala Val Lys Ser Ser 
        755                 760                 765             


Ser Ser Gln Pro Val Thr Pro Val Ser Pro Val Trp Ser Pro Gly Val 
    770                 775                 780                 


Ala Pro Thr Gln Pro Pro Ala Phe Pro Thr Ser Asn Pro Ser Lys Gly 
785                 790                 795                 800 


Thr Val Val Ser Ser Ile Lys Ile Ala Gln Pro Ser Tyr Pro Pro Ala 
                805                 810                 815     


Arg Pro Ala Ser Thr Leu Asn Val Ala Gly Pro Phe Lys Gly Pro Gln 
            820                 825                 830         


Ala Ala Val Ala Ser Gln Asn Tyr Thr Pro Lys Pro Thr Val Ser Thr 
        835                 840                 845             


Pro Thr Val Asn Ala Val Gln Pro Gly Ala Val Gly Pro Ser Asn Glu 
    850                 855                 860                 


Leu Pro Gly Met Ser Gly Arg Gly Ala Gln Leu Phe Ala Lys Arg Gln 
865                 870                 875                 880 


Ser Arg Met Glu Lys Tyr Val Val Asp Ser Asp Thr Val Gln Ala His 
                885                 890                 895     


Ala Ala Arg Ala Gln Ser Pro Thr Pro Ser Leu Pro Ala Ser Trp Lys 
            900                 905                 910         


Tyr Ser Ser Asn Val Arg Ala Pro Pro Pro Val Ala Tyr Asn Pro Ile 
        915                 920                 925             


His Ser Pro Ser Tyr Pro Leu Ala Ala Leu Lys Ser Gln Pro Ser Ala 
    930                 935                 940                 


Ala Gln Pro Ser Lys Met Gly Lys Lys Lys Gly Lys Lys Pro Leu Asn 
945                 950                 955                 960 


Ala Leu Asp Val Met Lys His Gln Pro Tyr Gln Leu Asn Ala Ser Leu 
                965                 970                 975     


Phe Thr Phe Gln Pro Pro Asp Ala Lys Asp Gly Leu Pro Gln Lys Ser 
            980                 985                 990         


Ser Val Lys Val Asn Ser Ala Leu  Ala Met Lys Gln Ala  Leu Pro Pro 
        995                 1000                 1005             


Arg Pro  Val Asn Ala Ala Ser  Pro Thr Asn Val Gln  Ala Ser Ser 
    1010                 1015                 1020             


Val Tyr  Ser Val Pro Ala Tyr  Thr Ser Pro Pro Ser  Phe Phe Ala 
    1025                 1030                 1035             


Glu Ala  Ser Ser Pro Val Ser  Ala Ser Pro Val Pro  Val Gly Ile 
    1040                 1045                 1050             


Pro Thr  Ser Pro Lys Gln Glu  Ser Ala Ser Ser Ser  Tyr Phe Val 
    1055                 1060                 1065             


Ala Pro  Arg Pro Lys Phe Ser  Ala Lys Lys Ser Gly  Val Thr Ile 
    1070                 1075                 1080             


Gln Glu  Ser Gly Arg Ser Leu  Ser Leu Pro Gly Arg  Ser Val Pro 
    1085                 1090                 1095             


Pro Pro  Ile Ser Thr Ser Pro  Trp Val Tyr Gln Pro  Thr Tyr Ser 
    1100                 1105                 1110             


Tyr Ser  Ser Lys Pro Thr Asp  Gly Leu Glu Lys Ala  Asn Lys Arg 
    1115                 1120                 1125             


Pro Thr  Pro Trp Glu Ala Ala  Ala Lys Ser Pro Leu  Gly Leu Val 
    1130                 1135                 1140             


Asp Asp  Ala Phe Gln Pro Arg  Asn Ile Gln Glu Ser  Ile Val Ala 
    1145                 1150                 1155             


Asn Val  Val Ser Ala Ala Arg  Arg Lys Val Leu Pro  Gly Pro Pro 
    1160                 1165                 1170             


Glu Asp  Trp Asn Glu Arg Leu  Ser Tyr Ile Pro Gln  Thr Gln Lys 
    1175                 1180                 1185             


Ala Tyr  Met Gly Ser Cys Gly  Arg Gln Glu Tyr Asn  Val Thr Ala 
    1190                 1195                 1200             


Asn Asn  Asn Met Ser Thr Thr  Ser Gln Tyr Gly Ser  Gln Leu Pro 
    1205                 1210                 1215             


Tyr Ala  Tyr Tyr Arg Gln Ala  Ser Arg Asn Asp Ser  Ala Ile Met 
    1220                 1225                 1230             


Ser Met  Glu Thr Arg Ser Asp  Tyr Cys Leu Pro Val  Ala Asp Tyr 
    1235                 1240                 1245             


Asn Tyr  Asn Pro His Pro Arg  Gly Trp Arg Arg Gln  Thr 
    1250                 1255                 1260     


<210> 5276
<211> 381
<212> PRT
<213> Homo sapiens

<400> 5276
Met Ser Trp Thr Val Pro Val Val Arg Ala Ser Gln Arg Val Ser Ser 
1               5                   10                  15      


Val Gly Ala Asn Phe Leu Cys Leu Gly Met Ala Leu Cys Pro Arg Gln 
            20                  25                  30          


Ala Thr Arg Ile Pro Leu Asn Gly Thr Trp Leu Phe Thr Pro Val Ser 
        35                  40                  45              


Lys Met Ala Thr Val Lys Ser Glu Leu Ile Glu Arg Phe Thr Ser Glu 
    50                  55                  60                  


Lys Pro Val His His Ser Lys Val Ser Ile Ile Gly Thr Gly Ser Val 
65                  70                  75                  80  


Gly Met Ala Cys Ala Ile Ser Ile Leu Leu Lys Gly Leu Ser Asp Glu 
                85                  90                  95      


Leu Ala Leu Val Asp Leu Asp Glu Asp Lys Leu Lys Gly Glu Thr Met 
            100                 105                 110         


Asp Leu Gln His Gly Ser Pro Phe Thr Lys Met Pro Asn Ile Val Cys 
        115                 120                 125             


Ser Lys Asp Tyr Phe Val Thr Ala Asn Ser Asn Leu Val Ile Ile Thr 
    130                 135                 140                 


Ala Gly Ala Arg Gln Glu Lys Gly Glu Thr Arg Leu Asn Leu Val Gln 
145                 150                 155                 160 


Arg Asn Val Ala Ile Phe Lys Leu Met Ile Ser Ser Ile Val Gln Tyr 
                165                 170                 175     


Ser Pro His Cys Lys Leu Ile Ile Val Ser Asn Pro Val Asp Ile Leu 
            180                 185                 190         


Thr Tyr Val Ala Trp Lys Leu Ser Ala Phe Pro Lys Asn Arg Ile Ile 
        195                 200                 205             


Gly Ser Gly Cys Asn Leu Asp Thr Ala Arg Phe Arg Phe Leu Ile Gly 
    210                 215                 220                 


Gln Lys Leu Gly Ile His Ser Glu Ser Cys His Gly Trp Ile Leu Gly 
225                 230                 235                 240 


Glu His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Val Asn Ile Ala 
                245                 250                 255     


Gly Val Pro Leu Lys Asp Leu Asn Ser Asp Ile Gly Thr Asp Lys Asp 
            260                 265                 270         


Pro Glu Gln Trp Lys Asn Val His Lys Glu Val Thr Ala Thr Ala Tyr 
        275                 280                 285             


Glu Ile Ile Lys Met Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser 
    290                 295                 300                 


Val Ala Asp Leu Thr Glu Ser Ile Leu Lys Asn Leu Arg Arg Ile His 
305                 310                 315                 320 


Pro Val Ser Thr Ile Ile Lys Gly Leu Tyr Gly Ile Asp Glu Glu Val 
                325                 330                 335     


Phe Leu Ser Ile Pro Cys Ile Leu Gly Glu Asn Gly Ile Thr Asn Leu 
            340                 345                 350         


Ile Lys Ile Lys Leu Thr Pro Glu Glu Glu Ala His Leu Lys Lys Ser 
        355                 360                 365             


Ala Lys Thr Leu Trp Glu Ile Gln Asn Lys Leu Lys Leu 
    370                 375                 380     


<210> 5277
<211> 286
<212> PRT
<213> Homo sapiens

<400> 5277
Met Met Ala Thr Pro Asn Gln Thr Ala Cys Asn Ala Glu Ser Pro Val 
1               5                   10                  15      


Ala Leu Glu Glu Ala Lys Thr Ser Gly Ala Pro Gly Ser Pro Gln Thr 
            20                  25                  30          


Pro Pro Glu Arg His Asp Ser Gly Gly Ser Leu Pro Leu Thr Pro Arg 
        35                  40                  45              


Met Glu Ser His Ser Glu Asp Glu Asp Leu Ala Gly Ala Val Gly Gly 
    50                  55                  60                  


Leu Gly Trp Asn Ser Arg Ser Pro Arg Thr Gln Ser Pro Gly Gly Cys 
65                  70                  75                  80  


Ser Ala Glu Ala Val Leu Ala Arg Lys Lys His Arg Arg Arg Pro Ser 
                85                  90                  95      


Lys Arg Lys Arg His Trp Arg Pro Tyr Leu Glu Leu Ser Trp Ala Glu 
            100                 105                 110         


Lys Gln Gln Arg Asp Glu Arg Gln Ser Gln Arg Ala Ser Arg Val Arg 
        115                 120                 125             


Glu Glu Met Phe Ala Lys Gly Gln Pro Val Ala Pro Tyr Asn Thr Thr 
    130                 135                 140                 


Gln Phe Leu Met Asn Asp Arg Asp Pro Glu Glu Pro Asn Leu Asp Val 
145                 150                 155                 160 


Pro His Gly Ile Ser His Pro Gly Ser Ser Gly Glu Ser Glu Ala Gly 
                165                 170                 175     


Asp Ser Asp Gly Arg Gly Arg Ala His Gly Glu Phe Gln Arg Lys Asp 
            180                 185                 190         


Phe Ser Glu Thr Tyr Glu Arg Phe His Thr Glu Ser Leu Gln Gly Arg 
        195                 200                 205             


Ser Lys Gln Glu Leu Val Arg Asp Tyr Leu Glu Leu Glu Lys Arg Leu 
    210                 215                 220                 


Ser Gln Ala Glu Glu Glu Thr Arg Arg Leu Gln Gln Leu Gln Ala Cys 
225                 230                 235                 240 


Thr Gly Gln Gln Ser Cys Arg Gln Val Glu Glu Leu Ala Ala Glu Val 
                245                 250                 255     


Gln Arg Leu Arg Thr Glu Asn Gln Arg Leu Arg Gln Glu Asn Gln Met 
            260                 265                 270         


Trp Asn Arg Glu Gly Cys Arg Cys Asp Glu Glu Pro Gly Thr 
        275                 280                 285     


<210> 5278
<211> 401
<212> PRT
<213> Homo sapiens

<400> 5278
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu Lys Phe Tyr Tyr 
                165                 170                 175     


Asn Pro Asn Phe Lys Arg Gly Tyr Pro Gln Leu Leu Val Arg Val Lys 
            180                 185                 190         


Arg Arg Ile Gly Val Lys Asn Ala Ser Pro Ile Ser Thr Leu Phe Asn 
        195                 200                 205             


Glu Asp Phe Asn Lys Lys His Phe Arg Ala Gly Ala Asn Met Glu Asn 
    210                 215                 220                 


His Asn Ser Ala Leu Ala Ala Glu Ala Ser Glu Glu Ser Leu Phe Ser 
225                 230                 235                 240 


Ala Ser Lys Asn Leu Asn Met Pro Leu Thr Arg Glu Ser Ser Val Arg 
                245                 250                 255     


Gln Ile Ile Ala Asn Ser Ser Val Pro Ile Arg Ser Gly Phe Pro Pro 
            260                 265                 270         


Pro Ser Pro Ser Thr Ser Val Gly Pro Ser Glu Gln Ile Ala Thr Asp 
        275                 280                 285             


Gln His Ala Ile Leu Asn Gln Leu Thr Thr Ile His Met His Ser His 
    290                 295                 300                 


Ser Thr Tyr Met Gln Ala Arg Gly His Ile Val Asn Phe Ile Thr Thr 
305                 310                 315                 320 


Thr Thr Ser Gln Tyr His Ile Ile Ser Pro Leu Gln Asn Gly Tyr Phe 
                325                 330                 335     


Gly Leu Thr Val Glu Pro Ser Ala Val Pro Thr Arg Tyr Pro Leu Val 
            340                 345                 350         


Ser Val Asn Glu Ala Pro Tyr Arg Asn Met Leu Pro Ala Gly Asn Pro 
        355                 360                 365             


Trp Leu Gln Met Pro Thr Ile Ala Asp Arg Ser Ala Ala Pro His Ser 
    370                 375                 380                 


Arg Leu Ala Leu Gln Pro Ser Pro Leu Asp Lys Tyr His Pro Asn Tyr 
385                 390                 395                 400 


Asn 
    


<210> 5279
<211> 575
<212> PRT
<213> Homo sapiens

<400> 5279
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 
            100                 105                 110         


Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 
        115                 120                 125             


Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 
    130                 135                 140                 


Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 
145                 150                 155                 160 


Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 
                165                 170                 175     


Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 
            180                 185                 190         


Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 
        195                 200                 205             


Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 
    210                 215                 220                 


Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 
225                 230                 235                 240 


His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 
                245                 250                 255     


Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 
            260                 265                 270         


Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 
        275                 280                 285             


Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 
    290                 295                 300                 


Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 
305                 310                 315                 320 


Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 
                325                 330                 335     


Gly Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn 
            340                 345                 350         


Tyr Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys 
        355                 360                 365             


Met Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser 
    370                 375                 380                 


Lys Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His 
385                 390                 395                 400 


Ala Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys 
                405                 410                 415     


Asp Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys 
            420                 425                 430         


Thr Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met 
        435                 440                 445             


Ser Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser 
    450                 455                 460                 


Ile Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro 
465                 470                 475                 480 


Phe Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala 
                485                 490                 495     


Gln Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg 
            500                 505                 510         


Leu Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr 
        515                 520                 525             


Val Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile 
    530                 535                 540                 


Thr Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala 
545                 550                 555                 560 


Glu Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 
                565                 570                 575 


<210> 5280
<211> 364
<212> PRT
<213> Homo sapiens

<400> 5280
Met Glu His Asn Gly Ser Ala Ser Asn Ala Asp Lys Ile His Gln Asn 
1               5                   10                  15      


Arg Leu Ser Ser Val Thr Glu Asp Glu Asp Gln Asp Ala Ala Leu Thr 
            20                  25                  30          


Ile Val Thr Val Leu Asp Lys Val Ala Ser Ile Val Asp Ser Val Gln 
        35                  40                  45              


Ala Ser Gln Lys Arg Ile Glu Glu Arg His Arg Glu Met Glu Asn Ala 
    50                  55                  60                  


Ile Lys Ser Val Gln Ile Asp Leu Leu Lys Leu Ser Gln Ser His Ser 
65                  70                  75                  80  


Asn Thr Gly His Ile Ile Asn Lys Leu Phe Glu Lys Thr Arg Lys Val 
                85                  90                  95      


Ser Ala His Ile Lys Asp Val Lys Ala Arg Val Glu Lys Gln Gln Ile 
            100                 105                 110         


His Val Lys Lys Val Glu Val Lys Gln Glu Glu Ile Met Lys Lys Asn 
        115                 120                 125             


Lys Phe Arg Val Val Ile Phe Gln Glu Lys Phe Arg Cys Pro Thr Ser 
    130                 135                 140                 


Leu Ser Val Val Lys Asp Arg Asn Leu Thr Glu Asn Gln Glu Glu Asp 
145                 150                 155                 160 


Asp Asp Asp Ile Phe Asp Pro Pro Val Asp Leu Ser Ser Asp Glu Glu 
                165                 170                 175     


Tyr Tyr Val Glu Glu Ser Arg Ser Ala Arg Leu Arg Lys Ser Gly Lys 
            180                 185                 190         


Glu His Ile Asp Asn Ile Lys Lys Ala Phe Ser Lys Glu Asn Met Gln 
        195                 200                 205             


Lys Thr Arg Gln Asn Leu Asp Lys Lys Val Asn Arg Ile Arg Thr Arg 
    210                 215                 220                 


Ile Val Thr Pro Glu Arg Arg Glu Arg Leu Arg Gln Ser Gly Glu Arg 
225                 230                 235                 240 


Leu Arg Gln Ser Gly Glu Arg Leu Arg Gln Ser Gly Glu Arg Phe Lys 
                245                 250                 255     


Lys Ser Ile Ser Asn Ala Ala Pro Ser Lys Glu Ala Phe Lys Met Arg 
            260                 265                 270         


Ser Leu Arg Lys Gly Lys Asp Arg Thr Val Ala Glu Gly Glu Glu Cys 
        275                 280                 285             


Ala Arg Glu Met Gly Val Asp Ile Ile Ala Arg Ser Glu Ser Leu Gly 
    290                 295                 300                 


Pro Ile Ser Glu Leu Tyr Ser Asp Glu Leu Ser Glu Pro Glu His Glu 
305                 310                 315                 320 


Ala Ala Arg Pro Val Tyr Pro Pro His Glu Gly Arg Glu Ile Pro Thr 
                325                 330                 335     


Pro Glu Pro Leu Lys Val Thr Phe Lys Ser Gln Val Lys Val Glu Asp 
            340                 345                 350         


Asp Glu Ser Leu Leu Leu Asp Leu Lys His Ser Ser 
        355                 360                 


<210> 5281
<211> 421
<212> PRT
<213> Homo sapiens

<400> 5281
Met Pro Thr Leu Ser Val Phe Met Asp Val Pro Leu Ala His Lys Leu 
1               5                   10                  15      


Glu Gly Ser Leu Leu Lys Thr Tyr Lys Gln Asp Asp Tyr Pro Asn Lys 
            20                  25                  30          


Ile Phe Leu Ala Tyr Arg Val Cys Met Thr Asn Glu Gly His Pro Trp 
        35                  40                  45              


Val Ser Leu Val Val Gln Lys Thr Arg Leu Gln Ile Ser Gln Asp Pro 
    50                  55                  60                  


Ser Leu Asn Tyr Glu Tyr Leu Pro Thr Met Gly Leu Lys Ser Phe Ile 
65                  70                  75                  80  


Gln Ala Ser Leu Ala Leu Leu Phe Gly Lys His Ser Gln Ala Ile Val 
                85                  90                  95      


Glu Asn Arg Val Gly Gly Val His Thr Val Gly Asp Ser Gly Ala Phe 
            100                 105                 110         


Gln Leu Gly Val Gln Phe Leu Arg Ala Trp His Lys Asp Ala Arg Ile 
        115                 120                 125             


Val Tyr Ile Ile Ser Ser Gln Lys Glu Leu His Gly Leu Val Phe Gln 
    130                 135                 140                 


Asp Met Gly Phe Thr Val Tyr Glu Tyr Ser Val Trp Asp Pro Lys Lys 
145                 150                 155                 160 


Leu Cys Met Asp Pro Asp Ile Leu Leu Asn Val Val Glu Gln Ile Pro 
                165                 170                 175     


His Gly Cys Val Leu Val Met Gly Asn Ile Ile Asp Cys Lys Leu Thr 
            180                 185                 190         


Pro Ser Gly Trp Ala Lys Leu Met Ser Met Ile Lys Ser Lys Gln Ile 
        195                 200                 205             


Phe Pro Phe Phe Asp Ile Pro Cys Gln Gly Leu Tyr Thr Ser Asp Leu 
    210                 215                 220                 


Glu Glu Asp Thr Arg Ile Leu Gln Tyr Phe Val Ser Gln Gly Phe Glu 
225                 230                 235                 240 


Phe Phe Cys Ser Gln Ser Leu Ser Lys Asn Phe Gly Ile Tyr Asp Glu 
                245                 250                 255     


Gly Val Gly Met Leu Val Val Val Ala Val Asn Asn Gln Gln Leu Leu 
            260                 265                 270         


Cys Val Leu Ser Gln Leu Glu Gly Leu Ala Gln Ala Leu Trp Leu Asn 
        275                 280                 285             


Pro Pro Asn Thr Gly Ala Arg Val Ile Thr Ser Ile Leu Cys Asn Pro 
    290                 295                 300                 


Ala Leu Leu Gly Glu Trp Lys Gln Ser Leu Lys Glu Val Val Glu Asn 
305                 310                 315                 320 


Ile Met Leu Thr Lys Glu Lys Val Lys Glu Lys Leu Gln Leu Leu Gly 
                325                 330                 335     


Thr Pro Gly Ser Trp Gly His Ile Thr Glu Gln Ser Gly Thr His Gly 
            340                 345                 350         


Tyr Leu Gly Leu Asn Ser Gln Gln Val Glu Tyr Leu Val Arg Lys Lys 
        355                 360                 365             


His Ile Tyr Ile Pro Lys Asn Gly Gln Ile Asn Phe Ser Cys Ile Asn 
    370                 375                 380                 


Ala Asn Asn Ile Asn Tyr Ile Thr Glu Gly Ile Asn Glu Ala Val Leu 
385                 390                 395                 400 


Leu Thr Glu Ser Ser Glu Met Cys Leu Pro Lys Glu Lys Lys Thr Leu 
                405                 410                 415     


Ile Gly Ile Lys Leu 
            420     


<210> 5282
<211> 191
<212> PRT
<213> Homo sapiens

<400> 5282
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
65                  70                  75                  80  


Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Thr Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg 
        115                 120                 125             


Arg Val Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Lys Leu Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro 
145                 150                 155                 160 


Phe Val Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala 
                165                 170                 175     


Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
            180                 185                 190     


<210> 5283
<211> 1068
<212> PRT
<213> Homo sapiens

<400> 5283
Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
                565                 570                 575     


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
            580                 585                 590         


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
        595                 600                 605             


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
    610                 615                 620                 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
625                 630                 635                 640 


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
                645                 650                 655     


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
            660                 665                 670         


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
        675                 680                 685             


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
    690                 695                 700                 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
705                 710                 715                 720 


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
                725                 730                 735     


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
            740                 745                 750         


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
        755                 760                 765             


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
    770                 775                 780                 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
785                 790                 795                 800 


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
                805                 810                 815     


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
            820                 825                 830         


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
        835                 840                 845             


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
    850                 855                 860                 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
865                 870                 875                 880 


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
                885                 890                 895     


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
            900                 905                 910         


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
        915                 920                 925             


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
    930                 935                 940                 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
945                 950                 955                 960 


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
                965                 970                 975     


Leu Leu Asn Ser Gln Gln Leu Thr Pro Glu Gln His Gln Ala Phe Leu 
            980                 985                 990         


Tyr Gln Leu Met Gln His His His  Gln Gln His His Gln  Pro Glu Leu 
        995                 1000                 1005             


Gln Gln  Leu Gln Ile Pro Gly  Pro Thr Gln Ile Pro  Ile Asn Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gly Thr Gln Ala  Pro Pro Leu His Thr  Ala Thr Thr 
    1025                 1030                 1035             


Asn Pro  Phe Leu Thr Ile His  Gly Asp Asn Ala Ser  Gln Lys Val 
    1040                 1045                 1050             


Ala Arg  Leu Ser Asp Lys Thr  Gly Pro Val Ala Gln  Glu Lys Ser 
    1055                 1060                 1065             


<210> 5284
<211> 450
<212> PRT
<213> Homo sapiens

<400> 5284
Met Ser Cys Leu Met Val Glu Arg Cys Gly Glu Ile Leu Phe Glu Asn 
1               5                   10                  15      


Pro Asp Gln Asn Ala Lys Cys Val Cys Met Leu Gly Asp Ile Arg Leu 
            20                  25                  30          


Arg Gly Gln Thr Gly Val Arg Ala Glu Arg Arg Gly Ser Tyr Pro Phe 
        35                  40                  45              


Ile Asp Phe Arg Leu Leu Asn Ser Thr Thr Tyr Ser Gly Glu Ile Gly 
    50                  55                  60                  


Thr Lys Lys Lys Val Lys Arg Leu Leu Ser Phe Gln Arg Tyr Phe His 
65                  70                  75                  80  


Ala Ser Arg Leu Leu Arg Gly Ile Ile Pro Gln Ala Pro Leu His Leu 
                85                  90                  95      


Leu Asp Glu Asp Tyr Leu Gly Gln Ala Arg His Met Leu Ser Lys Val 
            100                 105                 110         


Gly Met Trp Asp Phe Asp Ile Phe Leu Phe Asp Arg Leu Thr Asn Gly 
        115                 120                 125             


Asn Ser Leu Val Thr Leu Leu Cys His Leu Phe Asn Thr His Gly Leu 
    130                 135                 140                 


Ile His His Phe Lys Leu Asp Met Val Thr Leu His Arg Phe Leu Val 
145                 150                 155                 160 


Met Val Gln Glu Asp Tyr His Ser Gln Asn Pro Tyr His Asn Ala Val 
                165                 170                 175     


His Ala Ala Asp Val Thr Gln Ala Met His Cys Tyr Leu Lys Glu Pro 
            180                 185                 190         


Lys Leu Ala Ser Phe Leu Thr Pro Leu Asp Ile Met Leu Gly Leu Leu 
        195                 200                 205             


Ala Ala Ala Ala His Asp Val Asp His Pro Gly Val Asn Gln Pro Phe 
    210                 215                 220                 


Leu Ile Lys Thr Asn His His Leu Ala Asn Leu Tyr Gln Asn Met Ser 
225                 230                 235                 240 


Val Leu Glu Asn His His Trp Arg Ser Thr Ile Gly Met Leu Arg Glu 
                245                 250                 255     


Ser Arg Leu Leu Ala His Leu Pro Lys Glu Met Thr Gln Asp Ile Glu 
            260                 265                 270         


Gln Gln Leu Gly Ser Leu Ile Leu Ala Thr Asp Ile Asn Arg Gln Asn 
        275                 280                 285             


Glu Phe Leu Thr Arg Leu Lys Ala His Leu His Asn Lys Asp Leu Arg 
    290                 295                 300                 


Leu Glu Asp Ala Gln Asp Arg His Phe Met Leu Gln Ile Ala Leu Lys 
305                 310                 315                 320 


Cys Ala Asp Ile Cys Asn Pro Cys Arg Ile Trp Glu Met Ser Lys Gln 
                325                 330                 335     


Trp Ser Glu Arg Val Cys Glu Glu Phe Tyr Arg Gln Gly Glu Leu Glu 
            340                 345                 350         


Gln Lys Phe Glu Leu Glu Ile Ser Pro Leu Cys Asn Gln Gln Lys Asp 
        355                 360                 365             


Ser Ile Pro Ser Ile Gln Ile Gly Phe Met Ser Tyr Ile Val Glu Pro 
    370                 375                 380                 


Leu Phe Arg Glu Trp Ala His Phe Thr Gly Asn Ser Thr Leu Ser Glu 
385                 390                 395                 400 


Asn Met Leu Gly His Leu Ala His Asn Lys Ala Gln Trp Lys Ser Leu 
                405                 410                 415     


Leu Pro Arg Gln His Arg Ser Arg Gly Ser Ser Gly Ser Gly Pro Asp 
            420                 425                 430         


His Asp His Ala Gly Gln Gly Thr Glu Ser Glu Glu Gln Glu Gly Asp 
        435                 440                 445             


Ser Pro 
    450 


<210> 5285
<211> 755
<212> PRT
<213> Homo sapiens

<400> 5285
Met Ala Gly Cys Ile Pro Glu Glu Lys Thr Tyr Arg Arg Phe Leu Glu 
1               5                   10                  15      


Leu Phe Leu Gly Glu Phe Arg Gly Pro Cys Gly Gly Gly Glu Pro Glu 
            20                  25                  30          


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Ser Glu Pro Glu 
        35                  40                  45              


Pro Glu Pro Glu Leu Val Glu Ala Glu Ala Ala Glu Ala Ser Val Glu 
    50                  55                  60                  


Glu Pro Gly Glu Glu Ala Ala Thr Val Ala Ala Thr Glu Glu Gly Asp 
65                  70                  75                  80  


Gln Glu Gln Asp Pro Glu Pro Glu Glu Glu Ala Ala Val Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Gly Ala Ala Thr Ala Ala Ala Ala Pro Gly His Ser 
            100                 105                 110         


Ala Val Pro Pro Pro Pro Pro Gln Leu Pro Pro Leu Pro Pro Leu Pro 
        115                 120                 125             


Arg Pro Leu Ser Glu Arg Ile Thr Arg Glu Glu Val Glu Gly Glu Ser 
    130                 135                 140                 


Leu Asp Leu Cys Leu Gln Gln Leu Tyr Lys Tyr Asn Cys Pro Ser Phe 
145                 150                 155                 160 


Leu Ala Ala Ala Leu Ala Arg Ala Thr Ser Asp Glu Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Ser Ala His Tyr Ile Pro Lys Glu Thr Asp Gly Thr Glu Gly 
            180                 185                 190         


Thr Val Glu Ile Glu Thr Val Lys Leu Ala Arg Ser Val Phe Ser Lys 
        195                 200                 205             


Leu His Glu Ile Cys Cys Ser Trp Val Lys Asp Phe Pro Leu Arg Arg 
    210                 215                 220                 


Arg Pro Gln Leu Tyr Tyr Glu Thr Ser Ile His Ala Ile Lys Asn Met 
225                 230                 235                 240 


Arg Arg Lys Met Glu Asp Lys His Val Cys Ile Pro Asp Phe Asn Met 
                245                 250                 255     


Leu Phe Asn Leu Glu Asp Gln Glu Glu Gln Ala Tyr Phe Ala Val Phe 
            260                 265                 270         


Asp Gly His Gly Gly Val Asp Ala Ala Ile Tyr Ala Ser Ile His Leu 
        275                 280                 285             


His Val Asn Leu Val Arg Gln Glu Met Phe Pro His Asp Pro Ala Glu 
    290                 295                 300                 


Ala Leu Cys Arg Ala Phe Arg Val Thr Asp Glu Arg Phe Val Gln Lys 
305                 310                 315                 320 


Ala Ala Arg Glu Ser Leu Arg Cys Gly Thr Thr Gly Val Val Thr Phe 
                325                 330                 335     


Ile Arg Gly Asn Met Leu His Val Ala Trp Val Gly Asp Ser Gln Val 
            340                 345                 350         


Met Leu Val Arg Lys Gly Gln Ala Val Glu Leu Met Lys Pro His Lys 
        355                 360                 365             


Pro Asp Arg Glu Asp Glu Lys Gln Arg Ile Glu Ala Leu Gly Gly Cys 
    370                 375                 380                 


Val Val Trp Phe Gly Ala Trp Arg Val Asn Gly Ser Leu Ser Val Ser 
385                 390                 395                 400 


Arg Ala Ile Gly Asp Ala Glu His Lys Pro Tyr Ile Cys Gly Asp Ala 
                405                 410                 415     


Asp Ser Ala Ser Thr Val Leu Asp Gly Thr Glu Asp Tyr Leu Ile Leu 
            420                 425                 430         


Ala Cys Asp Gly Phe Tyr Asp Thr Val Asn Pro Asp Glu Ala Val Lys 
        435                 440                 445             


Val Val Ser Asp His Leu Lys Glu Asn Asn Gly Asp Ser Ser Met Val 
    450                 455                 460                 


Ala His Lys Leu Val Ala Ser Ala Arg Asp Ala Gly Ser Ser Asp Asn 
465                 470                 475                 480 


Ile Thr Val Ile Val Val Phe Leu Arg Asp Met Asn Lys Ala Val Asn 
                485                 490                 495     


Val Ser Glu Glu Ser Asp Trp Thr Glu Asn Ser Phe Gln Gly Gly Gln 
            500                 505                 510         


Glu Asp Gly Gly Asp Asp Lys Glu Asn His Gly Glu Cys Lys Arg Pro 
        515                 520                 525             


Trp Pro Gln His Gln Cys Ser Ala Pro Ala Asp Leu Gly Tyr Asp Gly 
    530                 535                 540                 


Arg Val Asp Ser Phe Thr Asp Arg Thr Ser Leu Ser Pro Gly Ser Gln 
545                 550                 555                 560 


Ile Asn Val Leu Glu Asp Pro Gly Tyr Leu Asp Leu Thr Gln Ile Glu 
                565                 570                 575     


Ala Ser Lys Pro His Ser Ala Gln Phe Leu Leu Pro Val Glu Met Phe 
            580                 585                 590         


Gly Pro Gly Ala Pro Lys Lys Ala Asn Leu Ile Asn Glu Leu Met Met 
        595                 600                 605             


Glu Lys Lys Ser Val Gln Ser Ser Leu Pro Glu Trp Ser Gly Ala Gly 
    610                 615                 620                 


Glu Phe Pro Thr Ala Phe Asn Leu Gly Ser Thr Gly Glu Gln Ile Tyr 
625                 630                 635                 640 


Arg Met Gln Ser Leu Ser Pro Val Cys Ser Gly Leu Glu Asn Glu Gln 
                645                 650                 655     


Phe Lys Ser Pro Gly Asn Arg Val Ser Arg Leu Ser His Leu Arg His 
            660                 665                 670         


His Tyr Ser Lys Lys Trp His Arg Phe Arg Phe Asn Pro Lys Phe Tyr 
        675                 680                 685             


Ser Phe Leu Ser Ala Gln Glu Pro Ser His Lys Ile Gly Thr Ser Leu 
    690                 695                 700                 


Ser Ser Leu Thr Gly Ser Gly Lys Arg Asn Arg Ile Arg Ser Ser Leu 
705                 710                 715                 720 


Pro Trp Arg Gln Asn Ser Trp Lys Gly Tyr Ser Glu Asn Met Arg Lys 
                725                 730                 735     


Leu Arg Lys Thr His Asp Ile Pro Cys Pro Asp Leu Pro Trp Ser Tyr 
            740                 745                 750         


Lys Ile Glu 
        755 


<210> 5286
<211> 256
<212> PRT
<213> Homo sapiens

<400> 5286
Met Ala Ser Arg Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly 
1               5                   10                  15      


His Leu Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser 
            20                  25                  30          


Thr Ala Val Gly Ile Arg Gly Thr Asn Ile Val Val Leu Gly Val Glu 
        35                  40                  45              


Lys Lys Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile 
    50                  55                  60                  


Cys Ala Leu Asp Asp His Val Cys Met Ala Phe Ala Val Leu Thr Ile 
65                  70                  75                  80  


Phe Ile Gly Leu Thr Ala Asp Ala Arg Val Val Ile Asn Arg Ala Arg 
                85                  90                  95      


Val Glu Cys Gln Ser His Lys Leu Thr Val Glu Asp Pro Val Thr Val 
            100                 105                 110         


Glu Tyr Ile Thr Arg Phe Ile Ala Thr Leu Lys Gln Lys Tyr Thr Gln 
        115                 120                 125             


Ser Asn Gly Arg Arg Pro Phe Gly Ile Ser Ala Leu Ile Val Gly Phe 
    130                 135                 140                 


Asp Asp Asp Gly Ile Ser Arg Leu Tyr Gln Thr Asp Pro Ser Gly Thr 
145                 150                 155                 160 


Tyr His Ala Trp Lys Ala Asn Ala Ile Gly Arg Ser Ala Lys Thr Val 
                165                 170                 175     


Arg Glu Phe Leu Glu Lys Asn Tyr Thr Glu Asp Ala Ile Ala Ser Asp 
            180                 185                 190         


Ser Glu Ala Ile Lys Leu Ala Ile Lys Ala Leu Leu Glu Val Val Gln 
        195                 200                 205             


Ser Gly Gly Lys Asn Ile Glu Leu Ala Ile Ile Arg Arg Asn Gln Pro 
    210                 215                 220                 


Leu Lys Met Phe Ser Ala Lys Glu Val Glu Leu Tyr Val Thr Glu Ile 
225                 230                 235                 240 


Glu Lys Glu Lys Glu Glu Ala Glu Lys Lys Lys Ser Lys Lys Ser Val 
                245                 250                 255     


<210> 5287
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 5287
Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp Leu Gln Lys 
                485                 490                 495     


Trp Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn His Ala Cys 
            500                 505                 510         


Leu Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser Ile Met Lys 
        515                 520                 525             


Arg Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg Tyr Gly Gly 
    530                 535                 540                 


Gly Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys Val Val Glu 
545                 550                 555                 560 


Arg Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu Asp Tyr Lys 
                565                 570                 575     


Thr Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Ser Asp Gly Phe 
            580                 585                 590         


Trp Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala Leu Glu 
        595                 600                 605             


Gln Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly Lys Met 
    610                 615                 620                 


Asn Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg Lys Glu 
625                 630                 635                 640 


Glu Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His Gly Glu 
                645                 650                 655     


Leu Cys Ile Ser Glu Asn Glu Arg Arg Leu Val Ser Lys Glu Ala Trp 
            660                 665                 670         


Ser Lys Leu Gln Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro Ser Tyr 
        675                 680                 685             


Lys Glu Cys Cys Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly Glu Glu 
    690                 695                 700                 


Asn Glu Ala Leu His Lys Met Ile Ala Asn Glu Gln Lys Thr Ser Leu 
705                 710                 715                 720 


Pro Asn Leu Phe Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn Trp Pro 
                725                 730                 735     


Glu Asp Thr Asp Val Leu Tyr Ile Val Ser Gln Phe Phe Val Glu Glu 
            740                 745                 750         


Trp Arg Lys Phe Val Arg Lys Pro Thr Arg Cys Ser Pro Val Ser Ser 
        755                 760                 765             


Val Gly Asn Ser Ala Leu Leu Cys Pro His Gly Gly Leu Met Phe Thr 
    770                 775                 780                 


Phe Ala Ser Met Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu Ile Trp 
785                 790                 795                 800 


Pro Ser Glu Trp Gln Met Ile Gln Lys Leu Phe Val Val Asp His Val 
                805                 810                 815     


Ile Lys Ile Thr Arg Ile Glu Val Gly Asp Val Asn Pro Ser Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ser Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu Gly Leu 
        835                 840                 845             


Leu Cys Gln Gln Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala Thr Ile 
    850                 855                 860                 


Tyr Val His Lys Val Val Asp Asn Lys Lys Val Met Lys Asp Ser Ala 
865                 870                 875                 880 


Pro Glu Leu Asn Val Ser Ser Ser Glu Thr Glu Glu Asp Lys Glu Glu 
                885                 890                 895     


Ala Lys Pro Asp Gly Glu Lys Asp Pro Asp Phe Asn Gln Ser Asn Gly 
            900                 905                 910         


Gly Thr Lys Arg Gln Lys Ile Ser His Gln Asn Tyr Ile Ala Tyr Gln 
        915                 920                 925             


Lys Gln Val Ile Arg Arg Ser Met Arg His Arg Lys Val Arg Gly Glu 
    930                 935                 940                 


Lys Ala Leu Leu Val Ser Ala Asn Gln Thr Leu Lys Glu Leu Lys Ile 
945                 950                 955                 960 


Gln Ile Met His Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser 
                965                 970                 975     


Ile Asp Gly Lys Ile Leu Ser Asp Asp Cys Ala Thr Leu Gly Thr Leu 
            980                 985                 990         


Gly Val Ile Pro Glu Ser Val Ile  Leu Leu Lys Ala Asp  Glu Pro Ile 
        995                 1000                 1005             


Ala Asp  Tyr Ala Ala Met Asp  Asp Val Met Gln Val  Cys Met Pro 
    1010                 1015                 1020             


Glu Glu  Gly Phe Lys Gly Thr  Gly Leu Leu Gly His  
    1025                 1030                 1035 


<210> 5288
<211> 793
<212> PRT
<213> Homo sapiens

<400> 5288
Met Leu Ile Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser 
1               5                   10                  15      


Val Lys Glu Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln 
            20                  25                  30          


Pro Gln Glu Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser 
        35                  40                  45              


Asn Lys Gln Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys 
    50                  55                  60                  


Pro Asn Leu Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln 
65                  70                  75                  80  


Glu Lys Lys Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His 
                85                  90                  95      


Gln Glu Val Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp 
            100                 105                 110         


Thr Ser Lys Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu 
        115                 120                 125             


Ile Ser Lys Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro 
    130                 135                 140                 


Lys Ser Lys Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr 
145                 150                 155                 160 


Pro Lys Leu Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys 
                165                 170                 175     


Gln Thr Pro Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr 
            180                 185                 190         


Thr Lys Ser Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln 
        195                 200                 205             


Pro Glu Thr Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His 
    210                 215                 220                 


Ser Leu Thr Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala 
225                 230                 235                 240 


Thr Ala Ser Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn 
                245                 250                 255     


Thr Glu Pro Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser 
            260                 265                 270         


Ser Ser Thr Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln 
        275                 280                 285             


Asp Leu Met Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser 
    290                 295                 300                 


Val Leu Asp Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro 
305                 310                 315                 320 


Pro Ser Ala Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu 
                325                 330                 335     


Ser Ser Gln Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Thr Ser Ser 
            340                 345                 350         


Pro Val Thr Cys Ser Ser Asn Ala Cys Leu Val Thr Thr Asp Gln Ala 
        355                 360                 365             


Ser Ser Gly Ser Glu Thr Glu Phe Met Thr Ser Glu Thr Pro Glu Ala 
    370                 375                 380                 


Ala Ile Pro Pro Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro 
385                 390                 395                 400 


Pro Met Ala Lys Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser 
                405                 410                 415     


Ser Ser Ser Val Thr Ile Asn Thr Ala Pro Phe Gln Ala Met Gln Thr 
            420                 425                 430         


Val Phe Asn Val Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile 
        435                 440                 445             


Lys Glu Ser Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala 
    450                 455                 460                 


Ser Thr Gln Thr Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu 
465                 470                 475                 480 


Gln Thr Val His Ser Gln Glu Thr Ala Asn Tyr His Pro Asp Gly Thr 
                485                 490                 495     


Ile Gln Val Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Thr Asn 
            500                 505                 510         


Val Phe Pro Arg Pro Thr Gln Pro Phe Val Asn Ser Arg Gly Ser Val 
        515                 520                 525             


Arg Gly Cys Thr Arg Gly Gly Arg Leu Ile Thr Asn Ser Tyr Arg Ser 
    530                 535                 540                 


Pro Gly Gly Tyr Lys Gly Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile 
545                 550                 555                 560 


Ser Asn Gly Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser 
                565                 570                 575     


Gly Ala Pro Tyr Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg 
            580                 585                 590         


Gly Gly Thr Ser Gly Gly Pro Arg Ala Asn Ser Arg Ala Gly Trp Ser 
        595                 600                 605             


Asp Ser Ser Gln Val Ser Ser Pro Glu Arg Asp Asn Glu Thr Phe Asn 
    610                 615                 620                 


Ser Gly Asp Ser Gly Gln Gly Asp Ser Arg Ser Met Thr Pro Val Asp 
625                 630                 635                 640 


Val Pro Val Thr Asn Pro Ala Ala Thr Ile Leu Pro Val His Val Tyr 
                645                 650                 655     


Pro Leu Pro Gln Gln Met Arg Val Ala Phe Ser Ala Ala Arg Thr Ser 
            660                 665                 670         


Asn Leu Ala Pro Gly Thr Leu Asp Gln Pro Ile Val Phe Asp Leu Leu 
        675                 680                 685             


Leu Asn Asn Leu Gly Glu Thr Phe Asp Leu Gln Leu Gly Arg Phe Asn 
    690                 695                 700                 


Cys Pro Val Asn Gly Thr Tyr Val Phe Ile Phe His Met Leu Lys Leu 
705                 710                 715                 720 


Ala Val Asn Val Pro Leu Tyr Val Asn Leu Met Lys Asn Glu Glu Val 
                725                 730                 735     


Leu Val Ser Ala Tyr Ala Asn Asp Gly Ala Pro Asp His Glu Thr Ala 
            740                 745                 750         


Ser Asn His Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln Ile Trp Leu 
        755                 760                 765             


Arg Leu His Arg Gly Ala Ile Tyr Gly Ser Ser Trp Lys Tyr Ser Thr 
    770                 775                 780                 


Phe Ser Gly Tyr Leu Leu Tyr Gln Asp 
785                 790             


<210> 5289
<211> 360
<212> PRT
<213> Homo sapiens

<400> 5289
Met Glu Glu Leu Ser Gln Ala Leu Ala Ser Ser Phe Ser Val Ser Gln 
1               5                   10                  15      


Asp Leu Asn Ser Thr Ala Ala Pro His Pro Arg Leu Ser Gln Tyr Lys 
            20                  25                  30          


Ser Lys Tyr Ser Ser Leu Glu Gln Ser Glu Arg Arg Arg Arg Leu Leu 
        35                  40                  45              


Glu Leu Gln Lys Ser Lys Arg Leu Asp Tyr Val Asn His Ala Arg Arg 
    50                  55                  60                  


Leu Ala Glu Asp Asp Trp Thr Gly Met Glu Ser Glu Glu Glu Asn Lys 
65                  70                  75                  80  


Lys Asp Asp Glu Glu Met Asp Ile Asp Thr Val Lys Lys Leu Pro Lys 
                85                  90                  95      


His Tyr Ala Asn Gln Leu Met Leu Ser Glu Trp Leu Ile Asp Val Pro 
            100                 105                 110         


Ser Asp Leu Gly Gln Glu Trp Ile Val Val Val Cys Pro Val Gly Lys 
        115                 120                 125             


Arg Ala Leu Ile Val Ala Ser Arg Gly Ser Thr Ser Ala Tyr Thr Lys 
    130                 135                 140                 


Ser Gly Tyr Cys Val Asn Arg Phe Ser Ser Leu Leu Pro Gly Gly Asn 
145                 150                 155                 160 


Arg Arg Asn Ser Thr Ala Lys Asp Tyr Thr Ile Leu Asp Cys Ile Tyr 
                165                 170                 175     


Asn Glu Val Asn Gln Thr Tyr Tyr Val Leu Asp Val Met Cys Trp Arg 
            180                 185                 190         


Gly His Pro Phe Tyr Asp Cys Gln Thr Asp Phe Arg Phe Tyr Trp Met 
        195                 200                 205             


His Ser Lys Leu Pro Glu Glu Glu Gly Leu Gly Glu Lys Thr Lys Leu 
    210                 215                 220                 


Asn Pro Phe Lys Phe Val Gly Leu Lys Asn Phe Pro Cys Thr Pro Glu 
225                 230                 235                 240 


Ser Leu Cys Asp Val Leu Ser Met Asp Phe Pro Phe Glu Val Asp Gly 
                245                 250                 255     


Leu Leu Phe Tyr His Lys Gln Thr His Tyr Ser Pro Gly Ser Thr Pro 
            260                 265                 270         


Leu Val Gly Trp Leu Arg Pro Tyr Met Val Ser Asp Val Leu Gly Val 
        275                 280                 285             


Ala Val Pro Ala Gly Pro Leu Thr Thr Lys Pro Asp Tyr Ala Gly His 
    290                 295                 300                 


Gln Leu Gln Gln Ile Met Glu His Lys Lys Ser Gln Lys Glu Gly Met 
305                 310                 315                 320 


Lys Glu Lys Leu Thr His Lys Ala Ser Glu Asn Gly His Tyr Glu Leu 
                325                 330                 335     


Glu His Leu Ser Thr Pro Lys Leu Lys Gly Ser Ser His Ser Pro Asp 
            340                 345                 350         


His Pro Gly Cys Leu Met Glu Asn 
        355                 360 


<210> 5290
<211> 174
<212> PRT
<213> Homo sapiens

<400> 5290
Leu Ile His Lys Pro Leu Lys Arg Ala Ile Thr Thr Leu Met Ala Gly 
1               5                   10                  15      


Ile Leu Arg Leu Val Val Gln Trp Pro Pro Gly Arg Leu Gln Thr Val 
            20                  25                  30          


Thr Lys Gly Val Glu Ser Leu Ile Cys Thr Asp Trp Ile Arg His Lys 
        35                  40                  45              


Phe Thr Arg Ser Arg Ile Pro Glu Lys Val Phe Gln Ala Ser Pro Glu 
    50                  55                  60                  


Asp His Glu Lys Tyr Gly Gly Asp Pro Gln Asn Pro His Lys Leu His 
65                  70                  75                  80  


Ile Val Thr Arg Ile Lys Ser Thr Arg Arg Arg Pro Tyr Trp Glu Lys 
                85                  90                  95      


Asp Ile Ile Lys Met Leu Gly Leu Glu Lys Ala His Thr Pro Gln Val 
            100                 105                 110         


His Lys Asn Ile Pro Ser Val Asn Ala Lys Leu Lys Val Val Lys His 
        115                 120                 125             


Leu Ile Arg Ile Lys Pro Leu Lys Leu Pro Gln Gly Leu Pro Ala Glu 
    130                 135                 140                 


Glu Asn Met Ser Asn Thr Cys Leu Lys Ser Thr Gly Glu Leu Val Val 
145                 150                 155                 160 


Gln Trp His Leu Lys Pro Val Glu Gln Lys Ala His Glu Ser 
                165                 170                 


<210> 5291
<211> 477
<212> PRT
<213> Homo sapiens

<400> 5291
Met Ala Thr Tyr Thr Cys Ile Thr Cys Arg Val Ala Phe Arg Asp Ala 
1               5                   10                  15      


Asp Met Gln Arg Ala His Tyr Lys Thr Asp Trp His Arg Tyr Asn Leu 
            20                  25                  30          


Arg Arg Lys Val Ala Ser Met Ala Pro Val Thr Ala Glu Gly Phe Gln 
        35                  40                  45              


Glu Arg Val Arg Ala Gln Arg Ala Val Ala Glu Glu Glu Ser Lys Gly 
    50                  55                  60                  


Ser Ala Thr Tyr Cys Thr Val Cys Ser Lys Lys Phe Ala Ser Phe Asn 
65                  70                  75                  80  


Ala Tyr Glu Asn His Leu Lys Ser Arg Arg His Val Glu Leu Glu Lys 
                85                  90                  95      


Lys Ala Val Gln Ala Val Asn Arg Lys Val Glu Met Met Asn Glu Lys 
            100                 105                 110         


Asn Leu Glu Lys Gly Leu Gly Val Asp Ser Val Asp Lys Asp Ala Met 
        115                 120                 125             


Asn Ala Ala Ile Gln Gln Ala Ile Lys Ala Gln Pro Ser Met Ser Pro 
    130                 135                 140                 


Lys Lys Ala Pro Pro Ala Pro Ala Lys Glu Ala Arg Asn Val Val Ala 
145                 150                 155                 160 


Val Gly Thr Gly Gly Arg Gly Thr His Asp Arg Asp Pro Ser Glu Lys 
                165                 170                 175     


Pro Pro Arg Leu Gln Trp Phe Glu Gln Gln Ala Lys Lys Leu Ala Lys 
            180                 185                 190         


Gln Gln Glu Glu Asp Ser Glu Glu Glu Glu Glu Asp Leu Asp Gly Asp 
        195                 200                 205             


Asp Trp Glu Asp Ile Asp Ser Asp Glu Glu Leu Glu Cys Glu Asp Thr 
    210                 215                 220                 


Glu Ala Met Asp Asp Val Val Glu Gln Asp Ala Glu Glu Glu Glu Ala 
225                 230                 235                 240 


Glu Glu Gly Pro Pro Leu Gly Ala Ile Pro Ile Thr Asp Cys Leu Phe 
                245                 250                 255     


Cys Ser His His Ser Ser Ser Leu Met Lys Asn Val Ala His Met Thr 
            260                 265                 270         


Lys Asp His Ser Phe Phe Ile Pro Asp Ile Glu Tyr Leu Ser Asp Ile 
        275                 280                 285             


Lys Gly Leu Ile Lys Tyr Leu Gly Glu Lys Val Gly Val Gly Lys Ile 
    290                 295                 300                 


Cys Leu Trp Cys Asn Glu Lys Gly Lys Ser Phe Tyr Ser Thr Glu Ala 
305                 310                 315                 320 


Val Gln Ala His Met Asn Asp Lys Ser His Cys Lys Leu Phe Thr Asp 
                325                 330                 335     


Gly Asp Ala Ala Leu Glu Phe Ala Asp Phe Tyr Asp Phe Arg Ser Ser 
            340                 345                 350         


Tyr Pro Asp His Lys Glu Gly Glu Asp Pro Asn Lys Ala Glu Glu Leu 
        355                 360                 365             


Pro Ser Glu Lys Asn Leu Glu Tyr Asp Asp Glu Thr Met Glu Leu Ile 
    370                 375                 380                 


Leu Pro Ser Gly Ala Arg Val Gly His Arg Ser Leu Met Arg Tyr Tyr 
385                 390                 395                 400 


Lys Gln Arg Phe Gly Leu Ser Arg Ala Val Ala Val Ala Lys Asn Arg 
                405                 410                 415     


Lys Ala Val Gly Arg Val Leu Gln Gln Tyr Arg Ala Leu Gly Trp Thr 
            420                 425                 430         


Gly Ser Thr Gly Ala Ala Leu Met Arg Glu Arg Asp Met Gln Tyr Val 
        435                 440                 445             


Gln Arg Met Lys Ser Lys Trp Met Leu Lys Thr Gly Met Lys Asn Asn 
    450                 455                 460                 


Ala Thr Lys Gln Met His Phe Arg Val Gln Val Arg Phe 
465                 470                 475         


<210> 5292
<211> 953
<212> PRT
<213> Homo sapiens

<400> 5292
Met Ile Thr Ser Ala Ala Gly Ile Ile Ser Leu Leu Asp Glu Asp Glu 
1               5                   10                  15      


Pro Gln Leu Lys Glu Phe Ala Leu His Lys Leu Asn Ala Val Val Asn 
            20                  25                  30          


Asp Phe Trp Ala Glu Ile Ser Glu Ser Val Asp Lys Ile Glu Val Leu 
        35                  40                  45              


Tyr Glu Asp Glu Gly Phe Arg Ser Arg Gln Phe Ala Ala Leu Val Ala 
    50                  55                  60                  


Ser Lys Val Phe Tyr His Leu Gly Ala Phe Glu Glu Ser Leu Asn Tyr 
65                  70                  75                  80  


Ala Leu Gly Ala Gly Asp Leu Phe Asn Val Asn Asp Asn Ser Glu Tyr 
                85                  90                  95      


Val Glu Thr Ile Ile Ala Lys Cys Ile Asp His Tyr Thr Lys Gln Cys 
            100                 105                 110         


Val Glu Asn Ala Asp Leu Pro Glu Gly Glu Lys Lys Pro Ile Asp Gln 
        115                 120                 125             


Arg Leu Glu Gly Ile Val Asn Lys Met Phe Gln Arg Cys Leu Asp Asp 
    130                 135                 140                 


His Lys Tyr Lys Gln Ala Ile Gly Ile Ala Leu Glu Thr Arg Arg Leu 
145                 150                 155                 160 


Asp Val Phe Glu Lys Thr Ile Leu Glu Ser Asn Asp Val Pro Gly Met 
                165                 170                 175     


Leu Ala Tyr Ser Leu Lys Leu Cys Met Ser Leu Met Gln Asn Lys Gln 
            180                 185                 190         


Phe Arg Asn Lys Val Leu Arg Val Leu Val Lys Ile Tyr Met Asn Leu 
        195                 200                 205             


Glu Lys Pro Asp Phe Ile Asn Val Cys Gln Cys Leu Ile Phe Leu Asp 
    210                 215                 220                 


Asp Pro Gln Ala Val Ser Asp Ile Leu Glu Lys Leu Val Lys Glu Asp 
225                 230                 235                 240 


Asn Leu Leu Met Ala Tyr Gln Ile Cys Phe Asp Leu Tyr Glu Ser Ala 
                245                 250                 255     


Ser Gln Gln Phe Leu Ser Ser Val Ile Gln Asn Leu Arg Thr Val Gly 
            260                 265                 270         


Thr Pro Ile Ala Ser Val Pro Gly Ser Thr Asn Thr Gly Thr Val Pro 
        275                 280                 285             


Gly Ser Glu Lys Asp Ser Asp Ser Met Glu Thr Glu Glu Lys Thr Ser 
    290                 295                 300                 


Ser Ala Phe Val Gly Lys Thr Pro Glu Ala Ser Pro Glu Pro Lys Asp 
305                 310                 315                 320 


Gln Thr Leu Lys Met Ile Lys Ile Leu Ser Gly Glu Met Ala Ile Glu 
                325                 330                 335     


Leu His Leu Gln Phe Leu Ile Arg Asn Asn Asn Thr Asp Leu Met Ile 
            340                 345                 350         


Leu Lys Asn Thr Lys Asp Ala Val Arg Asn Ser Val Cys His Thr Ala 
        355                 360                 365             


Thr Val Ile Ala Asn Ser Phe Met His Cys Gly Thr Thr Ser Asp Gln 
    370                 375                 380                 


Phe Leu Arg Asp Asn Leu Glu Trp Leu Ala Arg Ala Thr Asn Trp Ala 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Ala Ser Leu Gly Val Ile His Lys Gly His Glu 
                405                 410                 415     


Lys Glu Ala Leu Gln Leu Met Ala Thr Tyr Leu Pro Lys Asp Thr Ser 
            420                 425                 430         


Pro Gly Ser Ala Tyr Gln Glu Gly Gly Gly Leu Tyr Ala Leu Gly Leu 
        435                 440                 445             


Ile His Ala Asn His Gly Gly Asp Ile Ile Asp Tyr Leu Leu Asn Gln 
    450                 455                 460                 


Leu Lys Asn Ala Ser Asn Asp Ile Val Arg His Gly Gly Ser Leu Gly 
465                 470                 475                 480 


Leu Gly Leu Ala Ala Met Gly Thr Ala Arg Gln Asp Val Tyr Asp Leu 
                485                 490                 495     


Leu Lys Thr Asn Leu Tyr Gln Asp Asp Ala Val Thr Gly Glu Ala Ala 
            500                 505                 510         


Gly Leu Ala Leu Gly Leu Val Met Leu Gly Ser Lys Asn Ala Gln Ala 
        515                 520                 525             


Ile Glu Asp Met Val Gly Tyr Ala Gln Glu Thr Gln His Glu Lys Ile 
    530                 535                 540                 


Leu Arg Gly Leu Ala Val Gly Ile Ala Leu Val Met Tyr Gly Arg Met 
545                 550                 555                 560 


Glu Glu Ala Asp Ala Leu Ile Glu Ser Leu Cys Arg Asp Lys Asp Pro 
                565                 570                 575     


Ile Leu Arg Arg Ser Gly Met Tyr Thr Val Ala Met Ala Tyr Cys Gly 
            580                 585                 590         


Ser Gly Asn Asn Lys Ala Ile Arg Arg Leu Leu His Val Ala Val Ser 
        595                 600                 605             


Asp Val Asn Asp Asp Val Arg Arg Ala Ala Val Glu Ser Leu Gly Phe 
    610                 615                 620                 


Ile Leu Phe Arg Thr Pro Glu Gln Cys Pro Ser Val Val Ser Leu Leu 
625                 630                 635                 640 


Ser Glu Ser Tyr Asn Pro His Val Arg Tyr Gly Ala Ala Met Ala Leu 
                645                 650                 655     


Gly Ile Cys Cys Ala Gly Thr Gly Asn Lys Glu Ala Ile Asn Leu Leu 
            660                 665                 670         


Glu Pro Met Thr Asn Asp Pro Val Asn Tyr Val Arg Gln Gly Ala Leu 
        675                 680                 685             


Ile Ala Ser Ala Leu Ile Met Ile Gln Gln Thr Glu Ile Thr Cys Pro 
    690                 695                 700                 


Lys Val Asn Gln Phe Arg Gln Leu Tyr Ser Lys Val Ile Asn Asp Lys 
705                 710                 715                 720 


His Asp Asp Val Met Ala Lys Phe Gly Ala Ile Leu Ala Gln Gly Ile 
                725                 730                 735     


Leu Asp Ala Gly Gly His Asn Val Thr Ile Ser Leu Gln Ser Arg Thr 
            740                 745                 750         


Gly His Thr His Met Pro Ser Val Val Gly Val Leu Val Phe Thr Gln 
        755                 760                 765             


Phe Trp Phe Trp Phe Pro Leu Ser His Phe Leu Ser Leu Ala Tyr Thr 
    770                 775                 780                 


Pro Thr Cys Val Ile Gly Leu Asn Lys Asp Leu Lys Met Pro Lys Val 
785                 790                 795                 800 


Gln Tyr Lys Ser Asn Cys Lys Pro Ser Thr Phe Ala Tyr Pro Ala Pro 
                805                 810                 815     


Leu Glu Val Pro Lys Glu Lys Glu Lys Glu Lys Val Ser Thr Ala Val 
            820                 825                 830         


Leu Ser Ile Thr Ala Lys Ala Lys Lys Lys Glu Lys Glu Lys Glu Lys 
        835                 840                 845             


Lys Glu Glu Glu Lys Met Glu Val Asp Glu Ala Glu Lys Lys Glu Glu 
    850                 855                 860                 


Lys Glu Lys Lys Lys Glu Pro Glu Pro Asn Phe Gln Leu Leu Asp Asn 
865                 870                 875                 880 


Pro Ala Arg Val Met Pro Ala Gln Leu Lys Val Leu Thr Met Pro Glu 
                885                 890                 895     


Thr Cys Arg Tyr Gln Pro Phe Lys Pro Leu Ser Ile Gly Gly Ile Ile 
            900                 905                 910         


Ile Leu Lys Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val 
        915                 920                 925             


Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro 
    930                 935                 940                 


Pro Glu Pro Phe Glu Tyr Ile Asp Asp 
945                 950             


<210> 5293
<211> 327
<212> PRT
<213> Homo sapiens

<400> 5293
Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp Asp 
1               5                   10                  15      


Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala Tyr Tyr Thr Arg 
            20                  25                  30          


His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Arg Thr Arg Ser Leu Ser Gln Arg Gly Leu Gly Asn Cys Ser Ala Asn 
    50                  55                  60                  


Glu Ser Trp Thr Glu Val Ser Trp Pro Cys Arg Asn Ser Gln Ser Ser 
65                  70                  75                  80  


Glu Lys Ala Ile Asn Leu Gly Lys Lys Lys Ser Ser Trp Lys Ala Phe 
                85                  90                  95      


Phe Gly Val Val Glu Lys Glu Asp Ser Gln Ser Thr Pro Ala Lys Val 
            100                 105                 110         


Ser Ala Gln Gly Gln Arg Thr Leu Glu Tyr Gln Asp Ser His Ser Gln 
        115                 120                 125             


Gln Trp Ser Arg Cys Leu Ser Asn Val Glu Gln Cys Leu Glu His Glu 
    130                 135                 140                 


Ala Val Asp Pro Lys Val Ile Ser Ile Ala Asn Arg Val Ala Glu Ile 
145                 150                 155                 160 


Val Tyr Ser Trp Pro Pro Pro Gln Ala Thr Gln Ala Gly Gly Phe Lys 
                165                 170                 175     


Ser Lys Glu Ile Phe Val Thr Glu Gly Leu Ser Phe Gln Leu Gln Gly 
            180                 185                 190         


His Val Pro Val Ala Ser Ser Ser Lys Lys Asp Glu Glu Glu Gln Ile 
        195                 200                 205             


Leu Ala Lys Ile Val Glu Leu Leu Lys Tyr Ser Gly Asp Gln Leu Glu 
    210                 215                 220                 


Arg Lys Leu Lys Lys Asp Lys Ala Leu Met Gly His Phe Gln Asp Gly 
225                 230                 235                 240 


Leu Ser Tyr Ser Val Phe Lys Thr Ile Thr Asp Gln Val Leu Met Gly 
                245                 250                 255     


Val Asp Pro Arg Gly Glu Ser Glu Val Lys Ala Gln Gly Phe Lys Ala 
            260                 265                 270         


Ala Leu Val Ile Asp Val Thr Ala Lys Leu Thr Ala Ile Asp Asn His 
        275                 280                 285             


Pro Met Asn Arg Val Leu Gly Phe Gly Thr Lys Tyr Leu Lys Glu Asn 
    290                 295                 300                 


Phe Ser Pro Trp Ile Gln Gln His Gly Gly Trp Glu Lys Ile Leu Gly 
305                 310                 315                 320 


Ile Ser His Glu Glu Val Asp 
                325         


<210> 5294
<211> 361
<212> PRT
<213> Homo sapiens

<400> 5294
Met Gly Gly Ala Val Ser Ala Gly Glu Asp Asn Asp Glu Leu Ile Asp 
1               5                   10                  15      


Asn Leu Lys Glu Ala Gln Tyr Ile Arg Thr Glu Leu Val Glu Gln Ala 
            20                  25                  30          


Phe Arg Ala Ile Asp Arg Ala Asp Tyr Tyr Leu Glu Glu Phe Lys Glu 
        35                  40                  45              


Asn Ala Tyr Lys Asp Leu Ala Trp Lys His Gly Asn Ile His Leu Ser 
    50                  55                  60                  


Ala Pro Cys Ile Tyr Ser Glu Val Met Glu Ala Leu Asp Leu Gln Pro 
65                  70                  75                  80  


Gly Leu Ser Phe Leu Asn Leu Gly Ser Gly Thr Gly Tyr Leu Ser Ser 
                85                  90                  95      


Met Val Gly Leu Ile Leu Gly Pro Phe Gly Val Asn His Gly Val Glu 
            100                 105                 110         


Leu His Ser Asp Val Ile Glu Tyr Ala Lys Gln Lys Leu Asp Phe Phe 
        115                 120                 125             


Ile Arg Thr Ser Asp Ser Phe Asp Lys Phe Asp Phe Cys Glu Pro Ser 
    130                 135                 140                 


Phe Val Thr Gly Asn Cys Leu Glu Ile Ser Pro Asp Cys Ser Gln Tyr 
145                 150                 155                 160 


Asp Arg Val Tyr Cys Gly Ala Gly Val Gln Lys Glu His Glu Glu Tyr 
                165                 170                 175     


Met Lys Asn Leu Leu Lys Val Gly Gly Ile Leu Val Met Pro Leu Glu 
            180                 185                 190         


Glu Lys Leu Thr Lys Ile Thr Arg Thr Gly Pro Ser Ala Trp Glu Thr 
        195                 200                 205             


Lys Lys Ile Leu Ala Val Ser Phe Ala Pro Leu Ile Gln Pro Cys His 
    210                 215                 220                 


Ser Glu Ser Gly Lys Ser Arg Leu Val Gln Leu Pro Pro Val Ala Val 
225                 230                 235                 240 


Arg Ser Leu Gln Asp Leu Ala Arg Ile Ala Ile Arg Gly Thr Ile Lys 
                245                 250                 255     


Lys Ile Ile His Gln Glu Thr Val Ser Lys Asn Gly Asn Gly Leu Lys 
            260                 265                 270         


Asn Thr Pro Arg Phe Lys Arg Arg Arg Val Arg Arg Arg Arg Met Glu 
        275                 280                 285             


Thr Ile Val Phe Leu Asp Lys Glu Val Phe Ala Ser Arg Ile Ser Asn 
    290                 295                 300                 


Pro Ser Asp Asp Asn Ser Cys Glu Asp Leu Glu Glu Glu Arg Arg Glu 
305                 310                 315                 320 


Glu Glu Glu Lys Thr Pro Pro Glu Thr Lys Pro Asp Pro Pro Val Asn 
                325                 330                 335     


Phe Leu Arg Gln Lys Val Leu Ser Leu Pro Leu Pro Asp Pro Leu Lys 
            340                 345                 350         


Tyr Tyr Leu Leu Tyr Tyr Arg Glu Lys 
        355                 360     


<210> 5295
<211> 259
<212> PRT
<213> Homo sapiens

<400> 5295
Met Lys Asp Val Asp Asn Leu Lys Ser Ile Lys Glu Glu Trp Val Cys 
1               5                   10                  15      


Glu Thr Gly Ser Asp Asn Gln Pro Leu Gly Asn Asn Gln Gln Ser Asn 
            20                  25                  30          


Cys Glu Tyr Phe Val Asp Ser Leu Phe Glu Glu Ala Gln Lys Val Ser 
        35                  40                  45              


Ser Lys Cys Val Ser Pro Ala Glu Gln Lys Lys Gln Val Asp Val Asn 
    50                  55                  60                  


Ile Lys Leu Trp Lys Asn Gly Phe Thr Val Asn Asp Asp Phe Arg Ser 
65                  70                  75                  80  


Tyr Ser Asp Gly Ala Ser Gln Gln Phe Leu Asn Ser Ile Lys Lys Gly 
                85                  90                  95      


Glu Leu Pro Ser Glu Leu Gln Gly Ile Phe Asp Lys Glu Glu Val Asp 
            100                 105                 110         


Val Lys Val Glu Asp Lys Lys Asn Glu Ile Cys Leu Ser Thr Lys Pro 
        115                 120                 125             


Val Phe Gln Pro Phe Ser Gly Gln Gly His Arg Leu Gly Ser Ala Thr 
    130                 135                 140                 


Pro Lys Ile Val Ser Lys Ala Lys Asn Ile Glu Val Glu Asn Lys Asn 
145                 150                 155                 160 


Asn Leu Ser Ala Val Pro Leu Asn Asn Leu Glu Pro Ile Thr Asn Ile 
                165                 170                 175     


Gln Ile Trp Leu Ala Asn Gly Lys Arg Ile Val Gln Lys Phe Asn Ile 
            180                 185                 190         


Thr His Arg Val Ser His Ile Lys Asp Phe Ile Glu Lys Tyr Gln Gly 
        195                 200                 205             


Ser Gln Arg Ser Pro Pro Phe Ser Leu Ala Thr Ala Leu Pro Val Leu 
    210                 215                 220                 


Arg Leu Leu Asp Glu Thr Leu Thr Leu Glu Glu Ala Asp Leu Gln Asn 
225                 230                 235                 240 


Ala Val Ile Ile Gln Arg Leu Gln Lys Thr Ala Ser Phe Arg Glu Leu 
                245                 250                 255     


Ser Glu His 
            


<210> 5296
<211> 329
<212> PRT
<213> Homo sapiens

<400> 5296
Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Gly Lys Ile Gln Tyr Lys Glu Tyr Ile Ile Glu 
    290                 295                 300                 


Gly Phe Glu Asn Met Pro Ala Ala Phe Met Gly Met Leu Lys Gly Asp 
305                 310                 315                 320 


Asn Leu Gly Lys Thr Ile Val Lys Ala 
                325                 


<210> 5297
<211> 1001
<212> PRT
<213> Homo sapiens

<400> 5297
Met Gln Ser Thr Asp Leu Gly Asn Lys Glu Ser Gly Lys Ile Trp His 
1               5                   10                  15      


Arg Lys Pro Ser Pro Ala Thr Arg Asp Gly Ile Ile Val Asn Ile Ile 
            20                  25                  30          


His Asn Thr Ser Asp Tyr His Pro Lys Val Leu Arg Phe Leu Asn Val 
        35                  40                  45              


Ala Phe Asp Gly Thr Gly Asp Cys Leu Ile Ala Gly Asp His Gln Gly 
    50                  55                  60                  


Asn Ile Tyr Val Phe Asp Leu His Gly Asn Arg Phe Asn Leu Val Gln 
65                  70                  75                  80  


Arg Thr Ala Gln Ala Cys Thr Ala Leu Ala Phe Asn Leu Arg Arg Lys 
                85                  90                  95      


Ser Glu Phe Leu Val Ala Leu Ala Asp Tyr Ser Ile Lys Cys Phe Asp 
            100                 105                 110         


Thr Val Thr Lys Glu Leu Val Ser Trp Met Arg Gly His Glu Ser Ser 
        115                 120                 125             


Val Phe Ser Ile Ser Val His Ala Ser Gly Lys Tyr Ala Ile Thr Thr 
    130                 135                 140                 


Ser Ser Asp Thr Ala Gln Leu Trp Asp Leu Asp Thr Phe Gln Arg Lys 
145                 150                 155                 160 


Arg Lys Leu Asn Ile Arg Gln Ser Val Gly Ile Gln Lys Val Phe Phe 
                165                 170                 175     


Leu Pro Leu Ser Asn Thr Ile Leu Ser Cys Phe Lys Asp Asn Ser Ile 
            180                 185                 190         


Phe Ala Trp Glu Cys Asp Thr Leu Phe Cys Lys Tyr Gln Leu Pro Ala 
        195                 200                 205             


Pro Pro Glu Ser Ser Ser Ile Leu Tyr Lys Val Phe Ala Val Thr Arg 
    210                 215                 220                 


Asp Gly Arg Ile Leu Ala Ala Gly Gly Lys Ser Asn His Leu His Leu 
225                 230                 235                 240 


Trp Cys Leu Glu Ala Arg Gln Leu Phe Arg Ile Ile Gln Met Pro Thr 
                245                 250                 255     


Lys Val Arg Ala Ile Arg His Leu Glu Phe Leu Pro Asp Ser Phe Asp 
            260                 265                 270         


Ala Gly Ser Asn Gln Val Leu Gly Val Leu Ser Gln Asp Gly Ile Met 
        275                 280                 285             


Arg Phe Ile Asn Met Gln Thr Cys Lys Leu Leu Phe Glu Ile Gly Ser 
    290                 295                 300                 


Leu Asp Glu Gly Ile Ser Ser Ser Ala Ile Ser Pro His Gly Arg Tyr 
305                 310                 315                 320 


Ile Ala Ser Ile Met Glu Asn Gly Ser Leu Asn Ile Tyr Ser Val Gln 
                325                 330                 335     


Ala Leu Thr Gln Glu Ile Asn Lys Pro Pro Pro Pro Leu Val Lys Val 
            340                 345                 350         


Ile Glu Asp Leu Pro Lys Asn Lys Leu Ser Ser Ser Asp Leu Lys Met 
        355                 360                 365             


Lys Val Thr Ser Gly Arg Val Gln Gln Pro Ala Lys Ser Arg Glu Ser 
    370                 375                 380                 


Lys Met Gln Thr Arg Ile Leu Lys Gln Asp Leu Thr Gly Asp Phe Glu 
385                 390                 395                 400 


Ser Lys Lys Asn Glu Leu Pro Asp Gly Leu Asn Lys Lys Arg Leu Gln 
                405                 410                 415     


Ile Leu Leu Lys Gly Tyr Gly Glu Tyr Pro Thr Lys Tyr Arg Met Phe 
            420                 425                 430         


Ile Trp Arg Ser Leu Leu Gln Leu Pro Glu Asn His Thr Ala Phe Ser 
        435                 440                 445             


Thr Leu Ile Asp Lys Gly Thr His Val Ala Phe Leu Asn Leu Gln Lys 
    450                 455                 460                 


Lys Tyr Pro Ile Lys Ser Arg Lys Leu Leu Arg Val Leu Gln Arg Thr 
465                 470                 475                 480 


Leu Ser Ala Leu Ala His Trp Ser Val Ile Phe Ser Asp Thr Pro Tyr 
                485                 490                 495     


Leu Pro Leu Leu Ala Phe Pro Phe Val Lys Leu Phe Gln Asn Asn Gln 
            500                 505                 510         


Leu Ile Cys Phe Glu Val Ile Ala Thr Leu Ile Ile Asn Trp Cys Gln 
        515                 520                 525             


His Trp Phe Glu Tyr Phe Pro Asn Pro Pro Ile Asn Ile Leu Ser Met 
    530                 535                 540                 


Ile Glu Asn Val Leu Ala Phe His Asp Lys Glu Leu Leu Gln His Phe 
545                 550                 555                 560 


Ile Asp His Asp Ile Thr Ser Gln Leu Tyr Ala Trp Pro Leu Leu Glu 
                565                 570                 575     


Thr Val Phe Ser Glu Val Leu Thr Arg Glu Glu Trp Leu Lys Leu Phe 
            580                 585                 590         


Asp Asn Ile Phe Ser Asn His Pro Ser Phe Leu Leu Met Thr Val Val 
        595                 600                 605             


Ala Tyr Asn Ile Cys Ser Arg Thr Pro Leu Leu Ser Cys Asn Leu Lys 
    610                 615                 620                 


Asp Asp Phe Glu Phe Phe Phe His His Arg Asn Asn Leu Asp Ile Asn 
625                 630                 635                 640 


Val Val Ile Arg Gln Val Tyr His Leu Met Glu Thr Thr Pro Thr Asp 
                645                 650                 655     


Ile His Pro Asp Ser Met Leu Asn Val Phe Val Ala Leu Thr Lys Gly 
            660                 665                 670         


Gln Tyr Pro Val Phe Asn Gln Tyr Pro Lys Phe Ile Val Asp Tyr Gln 
        675                 680                 685             


Thr Gln Glu Arg Glu Arg Ile Arg Asn Asp Glu Leu Asp Tyr Leu Arg 
    690                 695                 700                 


Glu Arg Gln Thr Val Glu Asp Met Gln Ala Lys Val Asp Gln Gln Arg 
705                 710                 715                 720 


Val Glu Asp Glu Ala Trp Tyr Gln Lys Gln Glu Leu Leu Arg Lys Ala 
                725                 730                 735     


Glu Glu Thr Arg Arg Glu Met Leu Leu Gln Glu Glu Glu Lys Met Ile 
            740                 745                 750         


Gln Gln Arg Gln Arg Leu Ala Ala Val Lys Arg Glu Leu Lys Val Lys 
        755                 760                 765             


Glu Met His Leu Gln Asp Ala Ala Arg Arg Arg Phe Leu Lys Leu Gln 
    770                 775                 780                 


Gln Asp Gln Gln Glu Met Glu Leu Arg Arg Leu Asp Asp Glu Ile Gly 
785                 790                 795                 800 


Arg Lys Val Tyr Met Arg Asp Arg Glu Ile Ala Ala Thr Ala Arg Asp 
                805                 810                 815     


Leu Glu Met Arg Gln Leu Glu Leu Glu Ser Gln Lys Arg Leu Tyr Glu 
            820                 825                 830         


Lys Asn Leu Thr Glu Asn Gln Glu Ala Leu Ala Lys Glu Met Arg Ala 
        835                 840                 845             


Asp Ala Asp Ala Tyr Arg Arg Lys Val Asp Leu Glu Glu His Met Phe 
    850                 855                 860                 


His Lys Leu Ile Glu Ala Gly Glu Thr Gln Ser Gln Lys Thr Gln Lys 
865                 870                 875                 880 


Trp Lys Glu Ala Glu Gly Lys Glu Phe Arg Leu Arg Ser Ala Lys Lys 
                885                 890                 895     


Ala Ser Ala Leu Ser Asp Ala Ser Arg Lys Trp Phe Leu Lys Gln Glu 
            900                 905                 910         


Ile Asn Ala Ala Val Glu His Ala Glu Asn Pro Cys His Lys Glu Glu 
        915                 920                 925             


Pro Arg Phe Gln Asn Glu Gln Asp Ser Ser Cys Leu Pro Arg Thr Ser 
    930                 935                 940                 


Gln Leu Asn Asp Ser Ser Glu Met Asp Pro Ser Thr Gln Ile Ser Leu 
945                 950                 955                 960 


Asn Arg Arg Ala Val Glu Trp Asp Thr Thr Gly Gln Asn Leu Ile Lys 
                965                 970                 975     


Lys Val Arg Asn Leu Arg Gln Arg Leu Thr Ala Arg Ala Arg His Arg 
            980                 985                 990         


Cys Gln Thr Pro His Leu Leu Ala  Ala 
        995                 1000     


<210> 5298
<211> 216
<212> PRT
<213> Homo sapiens

<400> 5298
Met Ser Phe Leu Phe Gly Ser Arg Ser Ser Lys Thr Phe Lys Pro Lys 
1               5                   10                  15      


Lys Asn Ile Pro Glu Gly Ser His Gln Tyr Glu Leu Leu Lys His Ala 
            20                  25                  30          


Glu Ala Thr Leu Gly Ser Gly Asn Leu Arg Met Ala Val Met Leu Pro 
        35                  40                  45              


Glu Gly Glu Asp Leu Asn Glu Trp Val Ala Val Asn Thr Val Asp Phe 
    50                  55                  60                  


Phe Asn Gln Ile Asn Met Leu Tyr Gly Thr Ile Thr Asp Phe Cys Thr 
65                  70                  75                  80  


Glu Glu Ser Cys Pro Val Met Ser Ala Gly Pro Lys Tyr Glu Tyr His 
                85                  90                  95      


Trp Ala Asp Gly Thr Asn Ile Lys Lys Pro Ile Lys Cys Ser Ala Pro 
            100                 105                 110         


Lys Tyr Ile Asp Tyr Leu Met Thr Trp Val Gln Asp Gln Leu Asp Asp 
        115                 120                 125             


Glu Thr Leu Phe Pro Ser Lys Ile Gly Val Pro Phe Pro Lys Asn Phe 
    130                 135                 140                 


Met Ser Val Ala Lys Thr Ile Leu Lys Arg Leu Phe Arg Val Tyr Ala 
145                 150                 155                 160 


His Ile Tyr His Gln His Phe Asp Pro Val Ile Gln Leu Gln Glu Glu 
                165                 170                 175     


Ala His Leu Asn Thr Ser Phe Lys His Phe Ile Phe Phe Val Gln Glu 
            180                 185                 190         


Phe Asn Leu Ile Asp Arg Arg Glu Leu Ala Pro Leu Gln Glu Leu Ile 
        195                 200                 205             


Glu Lys Leu Thr Ser Lys Asp Arg 
    210                 215     


<210> 5299
<211> 158
<212> PRT
<213> Homo sapiens

<400> 5299
Met Ala Ala Gln Gly Val Gly Pro Gly Pro Gly Ser Ala Ala Pro Pro 
1               5                   10                  15      


Gly Leu Glu Ala Ala Arg Gln Lys Leu Ala Leu Arg Arg Lys Lys Val 
            20                  25                  30          


Leu Ser Thr Glu Glu Met Glu Leu Tyr Glu Leu Ala Gln Ala Ala Gly 
        35                  40                  45              


Gly Gly Ile Asp Pro Asp Val Phe Lys Ile Leu Val Asp Leu Leu Lys 
    50                  55                  60                  


Leu Asn Val Ala Pro Leu Ala Val Phe Gln Met Leu Lys Ser Met Cys 
65                  70                  75                  80  


Ala Gly Gln Arg Leu Ala Ser Glu Pro Gln Asp Pro Ala Ala Val Ser 
                85                  90                  95      


Leu Pro Thr Ser Ser Val Pro Glu Thr Arg Gly Arg Asp Lys Gly Ser 
            100                 105                 110         


Ala Ala Leu Gly Gly Val Leu Ala Leu Ala Glu Arg Ser Asn His Glu 
        115                 120                 125             


Gly Ser Ser Gln Arg Met Pro Arg Gln Pro Ser Ala Thr Arg Leu Pro 
    130                 135                 140                 


Lys Gly Gly Gly Pro Gly Lys Ser Pro Thr Gln Gly Ser Thr 
145                 150                 155             


<210> 5300
<211> 474
<212> PRT
<213> Homo sapiens

<400> 5300
Met Asn Ser Val Ser Pro Ala Ala Ala Gln Tyr Arg Ser Ser Ser Pro 
1               5                   10                  15      


Glu Asp Ala Arg Arg Arg Pro Glu Ala Arg Arg Pro Arg Gly Pro Arg 
            20                  25                  30          


Gly Pro Asp Pro Asn Gly Leu Gly Pro Ser Gly Ala Ser Gly Pro Ala 
        35                  40                  45              


Leu Gly Ser Pro Gly Ala Gly Pro Ser Glu Pro Asp Glu Val Asp Lys 
    50                  55                  60                  


Phe Lys Ala Lys Phe Leu Thr Ala Trp Asn Asn Val Lys Tyr Gly Trp 
65                  70                  75                  80  


Val Val Lys Ser Arg Thr Ser Phe Ser Lys Ile Ser Ser Ile His Leu 
                85                  90                  95      


Cys Gly Arg Arg Tyr Arg Phe Glu Gly Glu Gly Asp Ile Gln Arg Phe 
            100                 105                 110         


Gln Arg Asp Phe Val Ser Arg Leu Trp Leu Thr Tyr Arg Arg Asp Phe 
        115                 120                 125             


Pro Pro Leu Pro Gly Gly Cys Leu Thr Ser Asp Cys Gly Trp Gly Cys 
    130                 135                 140                 


Met Leu Arg Ser Gly Gln Met Met Leu Ala Gln Gly Leu Leu Leu His 
145                 150                 155                 160 


Phe Leu Pro Arg Asp Trp Thr Trp Ala Glu Gly Met Gly Leu Gly Pro 
                165                 170                 175     


Pro Glu Leu Ser Gly Ser Ala Ser Pro Ser Arg Tyr His Gly Pro Ala 
            180                 185                 190         


Arg Trp Met Pro Pro Arg Trp Ala Gln Gly Ala Pro Glu Leu Glu Gln 
        195                 200                 205             


Glu Arg Arg His Arg Gln Ile Val Ser Trp Phe Ala Asp His Pro Arg 
    210                 215                 220                 


Ala Pro Phe Gly Leu His Arg Leu Val Glu Leu Gly Gln Ser Ser Gly 
225                 230                 235                 240 


Lys Lys Ala Gly Asp Trp Tyr Gly Pro Ser Leu Val Ala His Ile Leu 
                245                 250                 255     


Arg Lys Ala Val Glu Ser Cys Ser Asp Val Thr Arg Leu Val Val Tyr 
            260                 265                 270         


Val Ser Gln Asp Cys Thr Val Tyr Lys Ala Asp Val Ala Arg Leu Val 
        275                 280                 285             


Ala Arg Pro Asp Pro Thr Ala Glu Trp Lys Ser Val Val Ile Leu Val 
    290                 295                 300                 


Pro Val Arg Leu Gly Gly Glu Thr Leu Asn Pro Val Tyr Val Pro Cys 
305                 310                 315                 320 


Val Lys Glu Leu Leu Arg Cys Glu Leu Cys Leu Gly Ile Met Gly Gly 
                325                 330                 335     


Lys Pro Arg His Ser Leu Tyr Phe Ile Gly Tyr Gln Asp Asp Phe Leu 
            340                 345                 350         


Leu Tyr Leu Asp Pro His Tyr Cys Gln Pro Thr Val Asp Val Ser Gln 
        355                 360                 365             


Ala Asp Phe Pro Leu Glu Ser Phe His Cys Thr Ser Pro Arg Lys Met 
    370                 375                 380                 


Ala Phe Ala Lys Met Asp Pro Ser Cys Thr Val Gly Phe Tyr Ala Gly 
385                 390                 395                 400 


Asp Arg Lys Glu Phe Glu Thr Leu Cys Ser Glu Leu Thr Arg Val Leu 
                405                 410                 415     


Ser Ser Ser Ser Ala Thr Glu Arg Tyr Pro Met Phe Thr Leu Ala Glu 
            420                 425                 430         


Gly His Ala Gln Asp His Ser Leu Asp Asp Leu Cys Ser Gln Leu Ala 
        435                 440                 445             


Gln Pro Thr Leu Arg Leu Pro Arg Thr Gly Arg Leu Leu Arg Ala Lys 
    450                 455                 460                 


Arg Pro Ser Ser Glu Asp Phe Val Phe Leu 
465                 470                 


<210> 5301
<211> 314
<212> PRT
<213> Homo sapiens

<400> 5301
Met Ala Phe Val Thr Arg Gln Phe Met Arg Ser Val Ser Ser Ser Ser 
1               5                   10                  15      


Thr Ala Ser Ala Ser Ala Lys Lys Ile Ile Val Lys His Val Thr Val 
            20                  25                  30          


Ile Gly Gly Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ala Ala Ala 
        35                  40                  45              


Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu Asp Ile Leu Ala 
    50                  55                  60                  


Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys Val Ala Lys Lys 
65                  70                  75                  80  


Lys Phe Ala Glu Asn Leu Lys Ala Gly Asp Glu Phe Val Glu Lys Thr 
                85                  90                  95      


Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser Val Val His Ser 
            100                 105                 110         


Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu Lys Val Lys Asn 
        115                 120                 125             


Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu His Thr Ile Phe 
    130                 135                 140                 


Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile Ala Asn Ala Thr 
145                 150                 155                 160 


Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe Asn Pro Val Pro 
                165                 170                 175     


Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met Thr Ser Gln Lys 
            180                 185                 190         


Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu Gly Lys His Pro 
        195                 200                 205             


Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn Arg Leu Leu Val 
    210                 215                 220                 


Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg Gly Asp Ala Ser 
225                 230                 235                 240 


Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala Gly Tyr Pro Met 
                245                 250                 255     


Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp Thr Thr Lys Phe 
            260                 265                 270         


Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn Pro Leu His Gln 
        275                 280                 285             


Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn Lys Phe Gly Lys 
    290                 295                 300                 


Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys 
305                 310                 


<210> 5302
<211> 269
<212> PRT
<213> Homo sapiens

<400> 5302
Met Gly Asn Cys Cys Trp Thr Gln Cys Phe Gly Leu Leu Arg Lys Glu 
1               5                   10                  15      


Ala Gly Arg Leu Gln Arg Val Gly Gly Gly Gly Gly Ser Lys Tyr Phe 
            20                  25                  30          


Arg Thr Cys Ser Arg Gly Glu His Leu Thr Ile Glu Phe Glu Asn Leu 
        35                  40                  45              


Val Glu Ser Asp Glu Gly Glu Ser Pro Gly Ser Ser His Arg Pro Leu 
    50                  55                  60                  


Thr Glu Glu Glu Ile Val Asp Leu Arg Glu Arg His Tyr Asp Ser Ile 
65                  70                  75                  80  


Ala Glu Lys Gln Lys Asp Leu Asp Lys Lys Ile Gln Lys Glu Gln Glu 
                85                  90                  95      


Arg Gln Arg Ile Val Gln Gln Tyr His Pro Ser Asn Asn Gly Glu Tyr 
            100                 105                 110         


Gln Ser Ser Gly Pro Glu Asp Asp Phe Glu Ser Cys Leu Arg Asn Met 
        115                 120                 125             


Lys Ser Gln Tyr Glu Val Phe Arg Ser Ser Arg Leu Ser Ser Asp Ala 
    130                 135                 140                 


Thr Val Leu Thr Pro Asn Thr Glu Ser Ser Cys Asp Leu Met Thr Lys 
145                 150                 155                 160 


Thr Lys Ser Thr Ser Gly Asn Asp Asp Ser Thr Ser Leu Asp Leu Glu 
                165                 170                 175     


Trp Glu Asp Glu Glu Gly Met Asn Arg Met Leu Pro Met Arg Glu Arg 
            180                 185                 190         


Ser Lys Thr Glu Glu Asp Ile Leu Arg Ala Ala Leu Lys Tyr Ser Asn 
        195                 200                 205             


Lys Lys Thr Gly Ser Asn Pro Thr Ser Ala Ser Asp Asp Ser Asn Gly 
    210                 215                 220                 


Leu Glu Trp Glu Asn Asp Phe Val Ser Ala Glu Met Asp Asp Asn Gly 
225                 230                 235                 240 


Asn Ser Glu Tyr Ser Gly Phe Val Asn Pro Val Leu Glu Leu Ser Asp 
                245                 250                 255     


Ser Gly Ile Arg His Ser Asp Thr Asp Gln Gln Thr Arg 
            260                 265                 


<210> 5303
<211> 456
<212> PRT
<213> Homo sapiens

<400> 5303
Met Lys Cys Glu His Cys Thr Arg Lys Glu Cys Ser Lys Lys Thr Lys 
1               5                   10                  15      


Thr Asp Asp Gln Glu Asn Val Ser Ala Asp Ala Pro Ser Pro Ala Gln 
            20                  25                  30          


Glu Asn Gly Glu Lys Gly Glu Phe His Lys Leu Ala Asp Ala Lys Ile 
        35                  40                  45              


Phe Leu Ser Asp Cys Leu Ala Cys Asp Ser Cys Met Thr Ala Glu Glu 
    50                  55                  60                  


Gly Val Gln Leu Ser Gln Gln Asn Ala Lys Asp Phe Phe Arg Val Leu 
65                  70                  75                  80  


Asn Leu Asn Lys Lys Cys Asp Thr Ser Lys His Lys Val Leu Val Val 
                85                  90                  95      


Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala Ala Lys Phe Asn Leu 
            100                 105                 110         


Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly Phe Leu Lys Ser Leu 
        115                 120                 125             


Gly Val His Tyr Val Phe Asp Thr Thr Ile Ala Ala Asp Phe Ser Ile 
    130                 135                 140                 


Leu Glu Ser Gln Lys Glu Phe Val Arg Arg Tyr Arg Gln His Ser Glu 
145                 150                 155                 160 


Glu Glu Arg Thr Leu Pro Met Leu Thr Ser Ala Cys Pro Gly Trp Val 
                165                 170                 175     


Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile Thr Ala His Leu Cys 
            180                 185                 190         


Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser Leu Val Lys Asp Tyr 
        195                 200                 205             


Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys Ile Phe His Val Ile 
    210                 215                 220                 


Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala Leu Gln Glu Ser Leu 
225                 230                 235                 240 


Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp Cys Val Leu Thr Ser 
                245                 250                 255     


Gly Glu Ile Ala Gln Ile Met Glu Gln Gly Asp Leu Ser Val Arg Asp 
            260                 265                 270         


Ala Ala Val Asp Thr Leu Phe Gly Asp Leu Lys Glu Asp Lys Val Thr 
        275                 280                 285             


Arg His Asp Gly Ala Ser Ser Asp Gly His Leu Ala His Ile Phe Arg 
    290                 295                 300                 


His Ala Ala Lys Glu Leu Phe Asn Glu Asp Val Glu Glu Val Thr Tyr 
305                 310                 315                 320 


Arg Ala Leu Arg Asn Lys Asp Phe Gln Glu Val Thr Leu Glu Lys Asn 
                325                 330                 335     


Gly Glu Val Val Leu Arg Phe Ala Ala Ala Tyr Gly Phe Arg Asn Ile 
            340                 345                 350         


Gln Asn Met Ile Leu Lys Leu Lys Lys Gly Lys Phe Pro Phe His Phe 
        355                 360                 365             


Val Glu Val Leu Ala Cys Ala Gly Gly Cys Leu Asn Gly Arg Gly Gln 
    370                 375                 380                 


Ala Gln Thr Pro Asp Gly His Ala Asp Lys Ala Leu Leu Arg Gln Met 
385                 390                 395                 400 


Glu Gly Ile Tyr Ala Asp Ile Pro Val Arg Arg Pro Glu Ser Ser Ala 
                405                 410                 415     


His Val Gln Glu Leu Tyr Gln Glu Trp Leu Glu Gly Ile Asn Ser Pro 
            420                 425                 430         


Lys Ala Arg Glu Val Leu His Thr Thr Tyr Gln Ser Gln Glu Arg Gly 
        435                 440                 445             


Thr His Ser Leu Asp Ile Lys Trp 
    450                 455     


<210> 5304
<211> 203
<212> PRT
<213> Homo sapiens

<400> 5304
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Ile Arg Phe Thr Lys 
                165                 170                 175     


Met Lys Leu Ser Arg Ser Ser Thr Tyr Glu Asn Arg Tyr Leu Cys Cys 
            180                 185                 190         


Asn Leu His Leu Lys Asp Glu Ser Asn Tyr Ser 
        195                 200             


<210> 5305
<211> 683
<212> PRT
<213> Homo sapiens

<400> 5305
Met Asn Thr Ser Ile Pro Tyr Gln Gln Asn Pro Tyr Asn Pro Arg Gly 
1               5                   10                  15      


Ser Ser Asn Val Ile Gln Cys Tyr Arg Cys Gly Asp Thr Cys Lys Gly 
            20                  25                  30          


Glu Val Val Arg Val His Asn Asn His Phe His Ile Arg Cys Phe Thr 
        35                  40                  45              


Cys Gln Val Cys Gly Cys Gly Leu Ala Gln Ser Gly Phe Phe Phe Lys 
    50                  55                  60                  


Asn Gln Glu Tyr Ile Cys Thr Gln Asp Tyr Gln Gln Leu Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys Asp Ser Cys Arg Asp Phe Ile Thr Gly Glu Val Ile Ser Ala 
                85                  90                  95      


Leu Gly Arg Thr Tyr His Pro Lys Cys Phe Val Cys Ser Leu Cys Arg 
            100                 105                 110         


Lys Pro Phe Pro Ile Gly Asp Lys Val Thr Phe Ser Gly Lys Glu Cys 
        115                 120                 125             


Val Cys Gln Thr Cys Ser Gln Ser Met Ala Ser Ser Lys Pro Ile Lys 
    130                 135                 140                 


Ile Arg Gly Pro Ser His Cys Ala Gly Cys Lys Glu Glu Ile Lys His 
145                 150                 155                 160 


Gly Gln Ser Leu Leu Ala Leu Asp Lys Gln Trp His Val Ser Cys Phe 
                165                 170                 175     


Lys Cys Gln Thr Cys Ser Val Ile Leu Thr Gly Glu Tyr Ile Ser Lys 
            180                 185                 190         


Asp Gly Val Pro Tyr Cys Glu Ser Asp Tyr His Ala Gln Phe Gly Ile 
        195                 200                 205             


Lys Cys Glu Thr Cys Asp Arg Tyr Ile Ser Gly Arg Val Leu Glu Ala 
    210                 215                 220                 


Gly Gly Lys His Tyr His Pro Thr Cys Ala Arg Cys Val Arg Cys His 
225                 230                 235                 240 


Gln Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Thr Gly Ser Glu Val 
                245                 250                 255     


Trp His Pro Ile Cys Lys Gln Ala Ala Arg Ala Glu Lys Lys Leu Lys 
            260                 265                 270         


His Arg Arg Thr Ser Glu Thr Ser Ile Ser Pro Pro Gly Ser Ser Ile 
        275                 280                 285             


Gly Ser Pro Asn Arg Val Ile Cys Ala Lys Val Asp Asn Glu Ile Leu 
    290                 295                 300                 


Asn Tyr Lys Asp Leu Ala Ala Leu Pro Lys Val Lys Ser Ile Tyr Glu 
305                 310                 315                 320 


Val Gln Arg Pro Asp Leu Ile Ser Tyr Glu Pro His Ser Arg Tyr Met 
                325                 330                 335     


Ser Asp Glu Met Leu Glu Arg Cys Gly Tyr Gly Glu Ser Leu Gly Thr 
            340                 345                 350         


Leu Ser Pro Tyr Ser Gln Asp Ile Tyr Glu Asn Leu Asp Leu Arg Gln 
        355                 360                 365             


Arg Arg Ala Ser Ser Pro Gly Tyr Ile Asp Ser Pro Thr Tyr Ser Arg 
    370                 375                 380                 


Gln Gly Met Ser Pro Thr Phe Ser Arg Ser Pro His His Tyr Tyr Arg 
385                 390                 395                 400 


Ser Gly Pro Glu Ser Gly Arg Ser Ser Pro Tyr His Ser Gln Leu Asp 
                405                 410                 415     


Val Arg Ser Ser Thr Pro Thr Ser Tyr Gln Ala Pro Lys His Phe His 
            420                 425                 430         


Ile Pro Ala Gly Asp Ser Asn Ile Tyr Arg Lys Pro Pro Ile Tyr Lys 
        435                 440                 445             


Arg His Gly Asp Leu Ser Thr Ala Thr Lys Ser Lys Thr Ser Glu Asp 
    450                 455                 460                 


Ile Ser Gln Thr Ser Lys Tyr Ser Pro Ile Tyr Ser Pro Asp Pro Tyr 
465                 470                 475                 480 


Tyr Ala Ser Glu Ser Glu Tyr Trp Thr Tyr His Gly Ser Pro Lys Val 
                485                 490                 495     


Pro Arg Ala Arg Arg Phe Ser Ser Gly Gly Glu Glu Asp Asp Phe Asp 
            500                 505                 510         


Arg Ser Met His Lys Leu Gln Ser Gly Ile Gly Arg Leu Ile Leu Lys 
        515                 520                 525             


Glu Glu Met Lys Ala Arg Ser Ser Ser Tyr Ala Asp Pro Trp Thr Pro 
    530                 535                 540                 


Pro Arg Ser Ser Thr Ser Ser Arg Glu Ala Leu His Thr Ala Gly Tyr 
545                 550                 555                 560 


Glu Met Ser Leu Asn Gly Ser Pro Arg Ser His Tyr Leu Ala Asp Ser 
                565                 570                 575     


Asp Pro Leu Ile Ser Lys Ser Ala Ser Leu Pro Ala Tyr Arg Arg Asn 
            580                 585                 590         


Gly Leu His Arg Thr Pro Ser Ala Asp Leu Phe His Tyr Asp Ser Met 
        595                 600                 605             


Asn Ala Val Asn Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr Glu 
    610                 615                 620                 


Leu Leu Leu Val Thr Thr Arg Gly Arg Asn Arg Leu Pro Lys Asp Val 
625                 630                 635                 640 


Asp Arg Thr Arg Leu Glu Arg His Leu Ser Gln Glu Glu Phe Tyr Gln 
                645                 650                 655     


Val Phe Gly Met Thr Ile Ser Glu Phe Asp Arg Leu Ala Leu Trp Lys 
            660                 665                 670         


Arg Asn Glu Leu Lys Lys Gln Ala Arg Leu Phe 
        675                 680             


<210> 5306
<211> 846
<212> PRT
<213> Homo sapiens

<400> 5306
Met Leu Phe Thr Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Thr Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Thr Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Thr Phe Leu Ser Asn Glu Glu Phe Thr Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Thr Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Thr Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Thr His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Thr Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Thr Ile Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Thr Tyr Glu Tyr Val Lys Phe Ile Gly Asn Phe Lys Ser Leu Asn Ser 
    210                 215                 220                 


Val Ser Ser Ser Ala His Asn Gly Phe Glu Gly Thr Ile Gln Arg Thr 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Thr Val Arg 
                245                 250                 255     


Leu Ala Thr Pro Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Glu Thr Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Thr Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Thr Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Thr Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Thr Pro Thr Lys Ile Pro Thr Asp Thr Ser Thr Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Val Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Ile Asn Ser Gln Ser Val Gly Ser Ser Leu Thr Gln 
                485                 490                 495     


Pro Val Met Ser Gln Ala Thr Asn Leu Pro Ile Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Thr Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Ser Asn Ile Gln Gln Leu 
            580                 585                 590         


Ala Pro Ile Asn Met Gln Gly Gln Val Val Pro Thr Asn Gln Ile Gln 
        595                 600                 605             


Ser Gly Met Asn Thr Gly His Ile Gly Thr Thr Gln His Met Ile Gln 
    610                 615                 620                 


Gln Gln Thr Leu Gln Ser Thr Ser Thr Gln Ser Gln Gln Asn Val Leu 
625                 630                 635                 640 


Ser Gly His Ser Gln Gln Thr Ser Leu Pro Ser Gln Thr Gln Ser Thr 
                645                 650                 655     


Leu Thr Ala Pro Leu Tyr Asn Thr Met Val Ile Ser Gln Pro Ala Ala 
            660                 665                 670         


Gly Ser Met Val Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Thr Gln 
        675                 680                 685             


Ser Ala Ala Val Thr Thr Phe Thr Gln Asp Arg Gln Ile Arg Phe Ser 
    690                 695                 700                 


Gln Gly Gln Gln Leu Val Thr Lys Leu Val Thr Ala Pro Val Ala Cys 
705                 710                 715                 720 


Gly Ala Val Met Val Pro Ser Thr Met Leu Met Gly Gln Val Val Thr 
                725                 730                 735     


Ala Tyr Pro Thr Phe Ala Thr Gln Gln Gln Gln Ser Gln Thr Leu Ser 
            740                 745                 750         


Val Thr Gln Gln Gln Gln Gln Gln Ser Ser Gln Glu Gln Gln Leu Thr 
        755                 760                 765             


Ser Val Gln Gln Pro Ser Gln Ala Gln Leu Thr Gln Pro Pro Gln Gln 
    770                 775                 780                 


Phe Leu Gln Thr Ser Arg Leu Leu His Gly Asn Pro Ser Thr Gln Leu 
785                 790                 795                 800 


Ile Leu Ser Ala Ala Phe Pro Leu Gln Gln Ser Thr Phe Pro Gln Ser 
                805                 810                 815     


His His Gln Gln His Gln Ser Gln Gln Gln Gln Gln Leu Ser Arg His 
            820                 825                 830         


Arg Thr Asp Ser Leu Pro Asp Pro Ser Lys Val Gln Pro Gln 
        835                 840                 845     


<210> 5307
<211> 551
<212> PRT
<213> Homo sapiens

<400> 5307
Met Gly Arg Lys Ala Ile Val Leu Ala Ile Ala Asn Thr Ser Leu Ala 
1               5                   10                  15      


Phe Pro Leu Cys Gln His Leu Val Thr Phe Cys Leu Gly Glu Asp Asp 
            20                  25                  30          


Gly Val His Thr Val Glu Asp Ala Ser Arg Lys Leu Ala Val Met Asp 
        35                  40                  45              


Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val Ser Pro 
    50                  55                  60                  


Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Glu Glu Leu Glu Ser 
65                  70                  75                  80  


Tyr Pro Leu Gly Ala Ile Val Arg Cys Asp Ala Val Met Pro Pro Gly 
                85                  90                  95      


Arg Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu Arg Ala 
            100                 105                 110         


Gln Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala Glu Leu 
        115                 120                 125             


Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser Gly Arg 
    130                 135                 140                 


Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu Leu Gln 
145                 150                 155                 160 


Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg Arg Pro 
                165                 170                 175     


Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly Arg Gly 
            180                 185                 190         


Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln Arg Pro 
        195                 200                 205             


Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro Asp Leu 
    210                 215                 220                 


Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg Glu Val 
225                 230                 235                 240 


Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val Ser Arg 
                245                 250                 255     


Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Arg Glu Arg 
            260                 265                 270         


Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu Thr Leu 
        275                 280                 285             


Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu Gln Lys 
    290                 295                 300                 


Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn Ile Ala 
305                 310                 315                 320 


Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly Pro Leu Gln 
                325                 330                 335     


Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser Val Arg 
            340                 345                 350         


Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp Asn Val 
        355                 360                 365             


Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser Trp Thr 
    370                 375                 380                 


Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr Arg Pro 
385                 390                 395                 400 


Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln Ser Arg 
                405                 410                 415     


Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg Arg Arg 
            420                 425                 430         


Arg Gln Val Thr Gln Ala Thr Gln Gln Gly Arg Gly Trp Glu Val Arg 
        435                 440                 445             


Gly Arg Gly Arg Ser Ala Trp Pro Arg Leu Thr Arg Leu Ser Tyr Phe 
    450                 455                 460                 


Leu Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His Arg Asp Leu 
465                 470                 475                 480 


Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly Lys Trp 
                485                 490                 495     


Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu Leu Ser 
            500                 505                 510         


Val Lys Gln Arg Asp Val Leu Glu Ala Leu Gln Asp Lys Glu Lys Val 
        515                 520                 525             


Ser Glu Leu Glu Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly 
    530                 535                 540                 


Glu Val Glu Met Glu Val Ile 
545                 550     


<210> 5308
<211> 562
<212> PRT
<213> Homo sapiens

<400> 5308
Met Ala Ala Ser Ala Lys Arg Lys Gln Glu Glu Lys His Leu Lys Met 
1               5                   10                  15      


Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp Cys 
            20                  25                  30          


Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe Val 
        35                  40                  45              


Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His Arg 
    50                  55                  60                  


Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu Phe 
65                  70                  75                  80  


Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly Leu 
                85                  90                  95      


Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln Lys 
            100                 105                 110         


Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr Val 
        115                 120                 125             


Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile Ser 
    130                 135                 140                 


Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro Leu 
145                 150                 155                 160 


Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys Gly 
                165                 170                 175     


Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln Gln 
            180                 185                 190         


Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile Phe 
        195                 200                 205             


Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn Phe 
    210                 215                 220                 


Ala His Phe Asn Ser His Ala Ala Gln Asn Ser Ala Asn Ala Asp Phe 
225                 230                 235                 240 


Ala Asn Phe Asp Ala Phe Gly Gln Ser Ser Gly Ser Ser Asn Phe Gly 
                245                 250                 255     


Gly Phe Pro Thr Ala Ser His Ser Pro Phe Gln Pro Gln Thr Thr Gly 
            260                 265                 270         


Gly Ser Ala Ala Ser Val Asn Ala Asn Phe Ala His Phe Asp Asn Phe 
        275                 280                 285             


Pro Lys Ser Ser Ser Ala Asp Phe Gly Thr Phe Asn Thr Ser Gln Ser 
    290                 295                 300                 


His Gln Thr Ala Ser Ala Val Ser Lys Val Ser Thr Asn Lys Ala Gly 
305                 310                 315                 320 


Leu Gln Thr Ala Asp Lys Tyr Ala Ala Leu Ala Asn Leu Asp Asn Ile 
                325                 330                 335     


Phe Ser Ala Gly Gln Gly Gly Asp Gln Gly Ser Gly Phe Gly Thr Thr 
            340                 345                 350         


Gly Lys Ala Pro Val Gly Ser Val Val Ser Val Pro Ser Gln Ser Ser 
        355                 360                 365             


Ala Ser Ser Asp Lys Tyr Ala Ala Leu Ala Glu Leu Asp Ser Val Phe 
    370                 375                 380                 


Ser Ser Ala Ala Thr Ser Ser Asn Ala Tyr Thr Ser Thr Ser Asn Ala 
385                 390                 395                 400 


Ser Ser Asn Val Phe Gly Thr Val Pro Val Val Ala Ser Ala Gln Thr 
                405                 410                 415     


Gln Pro Ala Ser Ser Ser Val Pro Ala Pro Phe Gly Ala Thr Pro Ser 
            420                 425                 430         


Thr Asn Pro Phe Val Ala Ala Ala Gly Pro Ser Val Ala Ser Ser Thr 
        435                 440                 445             


Asn Pro Phe Gln Thr Asn Ala Arg Gly Ala Thr Ala Ala Thr Phe Gly 
    450                 455                 460                 


Thr Ala Ser Met Ser Met Pro Thr Gly Phe Gly Thr Pro Ala Pro Tyr 
465                 470                 475                 480 


Ser Leu Pro Thr Ser Phe Ser Gly Ser Phe Gln Gln Pro Ala Phe Pro 
                485                 490                 495     


Ala Gln Ala Ala Phe Pro Gln Gln Thr Ala Phe Ser Gln Gln Pro Asn 
            500                 505                 510         


Gly Ala Gly Phe Ala Ala Phe Gly Gln Thr Lys Pro Val Val Thr Pro 
        515                 520                 525             


Phe Gly Gln Val Ala Ala Ala Gly Val Ser Ser Asn Pro Phe Met Thr 
    530                 535                 540                 


Gly Ala Pro Thr Gly Gln Phe Pro Thr Gly Ser Ser Ser Thr Asn Pro 
545                 550                 555                 560 


Phe Leu 
        


<210> 5309
<211> 683
<212> PRT
<213> Homo sapiens

<400> 5309
Met Ala Ala Ala Val Ala Ala Pro Leu Ala Ala Gly Gly Glu Glu Ala 
1               5                   10                  15      


Ala Ala Thr Thr Ser Val Pro Gly Ser Pro Gly Leu Pro Gly Arg Arg 
            20                  25                  30          


Ser Ala Glu Arg Ala Leu Glu Glu Ala Val Ala Thr Gly Thr Leu Asn 
        35                  40                  45              


Leu Ser Asn Arg Arg Leu Lys His Phe Pro Arg Gly Ala Ala Arg Ser 
    50                  55                  60                  


Tyr Asp Leu Ser Asp Ile Thr Gln Ala Asp Leu Ser Arg Asn Arg Phe 
65                  70                  75                  80  


Pro Glu Val Pro Glu Ala Ala Cys Gln Leu Val Ser Leu Glu Gly Leu 
                85                  90                  95      


Ser Leu Tyr His Asn Cys Leu Arg Cys Leu Asn Pro Ala Leu Gly Asn 
            100                 105                 110         


Leu Thr Ala Leu Thr Tyr Leu Asn Leu Ser Arg Asn Gln Leu Ser Leu 
        115                 120                 125             


Leu Pro Pro Tyr Ile Cys Gln Leu Pro Leu Arg Val Leu Ile Val Ser 
    130                 135                 140                 


Asn Asn Lys Leu Gly Ala Leu Pro Pro Asp Ile Gly Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Arg Gln Leu Asp Val Ser Ser Asn Glu Leu Gln Ser Leu Pro Ser 
                165                 170                 175     


Glu Leu Cys Gly Leu Ser Ser Leu Arg Asp Leu Asn Val Arg Arg Asn 
            180                 185                 190         


Gln Leu Ser Thr Leu Pro Glu Glu Leu Gly Asp Leu Pro Leu Val Arg 
        195                 200                 205             


Leu Asp Phe Ser Cys Asn Arg Val Ser Arg Ile Pro Val Ser Phe Cys 
    210                 215                 220                 


Arg Leu Arg His Leu Gln Val Ile Leu Leu Asp Ser Asn Pro Leu Gln 
225                 230                 235                 240 


Ser Pro Pro Ala Gln Val Cys Leu Lys Gly Lys Leu His Ile Phe Lys 
                245                 250                 255     


Tyr Leu Ser Thr Glu Ala Gly Gln Arg Gly Ser Ala Leu Gly Asp Leu 
            260                 265                 270         


Ala Pro Ser Arg Pro Pro Ser Phe Ser Pro Cys Pro Ala Glu Asp Leu 
        275                 280                 285             


Phe Pro Gly His Arg Tyr Asp Gly Gly Leu Asp Ser Gly Phe His Ser 
    290                 295                 300                 


Val Asp Ser Gly Ser Lys Arg Trp Ser Gly Asn Glu Ser Thr Asp Glu 
305                 310                 315                 320 


Phe Ser Glu Leu Ser Phe Arg Ile Ser Glu Leu Ala Arg Glu Pro Arg 
                325                 330                 335     


Gly Pro Arg Glu Arg Lys Glu Asp Gly Ser Ala Asp Gly Asp Pro Val 
            340                 345                 350         


Gln Ile Asp Phe Ile Asp Ser His Val Pro Gly Glu Asp Glu Glu Arg 
        355                 360                 365             


Gly Thr Val Glu Glu Gln Arg Pro Pro Glu Leu Ser Pro Gly Ala Gly 
    370                 375                 380                 


Asp Arg Glu Arg Ala Pro Ser Ser Arg Arg Glu Glu Pro Ala Gly Glu 
385                 390                 395                 400 


Glu Arg Arg Arg Pro Asp Thr Leu Gln Leu Trp Gln Glu Arg Glu Arg 
                405                 410                 415     


Arg Gln Gln Gln Gln Ser Gly Ala Trp Gly Ala Pro Arg Lys Asp Ser 
            420                 425                 430         


Leu Leu Lys Pro Gly Leu Arg Ala Val Val Gly Gly Ala Ala Ala Val 
        435                 440                 445             


Ser Thr Gln Ala Met His Asn Gly Ser Pro Lys Ser Ser Ala Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ala Ala Gly Gln Gly Ala Pro Ala Pro Ala Pro Ala Ser 
465                 470                 475                 480 


Gln Glu Pro Leu Pro Ile Ala Gly Pro Ala Thr Ala Pro Ala Pro Arg 
                485                 490                 495     


Pro Leu Gly Ser Ile Gln Arg Pro Asn Ser Phe Leu Phe Arg Ser Ser 
            500                 505                 510         


Ser Gln Ser Gly Ser Gly Pro Ser Ser Pro Asp Ser Val Leu Arg Pro 
        515                 520                 525             


Arg Arg Tyr Pro Gln Val Pro Asp Glu Lys Asp Leu Met Thr Gln Leu 
    530                 535                 540                 


Arg Gln Val Leu Glu Ser Arg Leu Gln Arg Pro Leu Pro Glu Asp Leu 
545                 550                 555                 560 


Ala Glu Ala Leu Ala Ser Gly Val Ile Leu Cys Gln Leu Ala Asn Gln 
                565                 570                 575     


Leu Arg Pro Arg Ser Val Pro Phe Ile His Val Pro Ser Pro Ala Val 
            580                 585                 590         


Pro Lys Leu Ser Ala Leu Lys Ala Arg Lys Asn Val Glu Ser Phe Leu 
        595                 600                 605             


Glu Ala Cys Arg Lys Met Gly Val Pro Glu Ala Asp Leu Cys Ser Pro 
    610                 615                 620                 


Ser Asp Leu Leu Gln Gly Thr Ala Arg Gly Leu Arg Thr Ala Leu Glu 
625                 630                 635                 640 


Ala Val Lys Arg Val Gly Gly Lys Ala Leu Pro Pro Leu Trp Pro Pro 
                645                 650                 655     


Ser Gly Leu Gly Gly Phe Val Val Phe Tyr Val Val Leu Met Leu Leu 
            660                 665                 670         


Leu Tyr Val Thr Tyr Thr Arg Leu Leu Gly Ser 
        675                 680             


<210> 5310
<211> 100
<212> PRT
<213> Homo sapiens

<400> 5310
Met Ser Thr Ser Thr Ser Cys Pro Ile Pro Gly Gly Arg Asp Gln Leu 
1               5                   10                  15      


Pro Asp Cys Tyr Ser Thr Thr Pro Gly Gly Thr Leu Tyr Ala Thr Thr 
            20                  25                  30          


Pro Gly Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Leu Glu Cys 
        35                  40                  45              


Lys Asn Ser Pro Ile Ala Arg Thr Pro Pro Cys Cys Leu Pro Gln Ile 
    50                  55                  60                  


Pro Gly Val Thr Thr Pro Pro Thr Ala Pro Leu Ser Lys Leu Glu Glu 
65                  70                  75                  80  


Leu Lys Glu Gln Glu Thr Glu Glu Glu Ile Pro Asp Asp Ala Gln Phe 
                85                  90                  95      


Glu Met Asp Ile 
            100 


<210> 5311
<211> 793
<212> PRT
<213> Homo sapiens

<400> 5311
Met Pro Met Glu Ser Ala Ser Ser Asp Asn Lys Lys Gln Ile Pro Asn 
1               5                   10                  15      


Glu Ala Ser Ala Arg Ser Glu Arg Asp Thr Ser Asp Leu Glu Gln Asn 
            20                  25                  30          


Trp Ser Leu Gln Asp His Tyr Arg Met Tyr Ser Pro Ile Ile Tyr Gln 
        35                  40                  45              


Ala Leu Cys Glu His Val Gln Thr Gln Met Ser Leu Met Asn Asp Leu 
    50                  55                  60                  


Thr Ser Lys Asn Ile Pro Asn Gly Ile Pro Ala Val Pro Cys His Ala 
65                  70                  75                  80  


Pro Ser His Ser Glu Ser Gln Ala Thr Pro His Ser Ser Tyr Gly Leu 
                85                  90                  95      


Cys Thr Ser Thr Pro Val Trp Ser Leu Gln Arg Pro Pro Cys Pro Pro 
            100                 105                 110         


Lys Val His Ser Glu Val Gln Thr Asp Gly Asn Ser Gln Phe Ala Ser 
        115                 120                 125             


Gln Gly Lys Thr Val Ser Ala Thr Cys Thr Asp Val Leu Arg Asn Ser 
    130                 135                 140                 


Phe Asn Thr Ser Pro Gly Val Pro Cys Ser Leu Pro Lys Thr Asp Ile 
145                 150                 155                 160 


Ser Ala Ile Pro Thr Leu Gln Gln Leu Gly Leu Val Asn Gly Ile Leu 
                165                 170                 175     


Pro Gln Gln Gly Ile His Lys Glu Thr Asp Leu Leu Lys Cys Ile Gln 
            180                 185                 190         


Thr Tyr Leu Ser Leu Phe Arg Ser His Gly Lys Glu Thr His Leu Asp 
        195                 200                 205             


Ser Gln Thr His Arg Ser Pro Thr Gln Ser Gln Pro Ala Phe Leu Ala 
    210                 215                 220                 


Thr Asn Glu Glu Lys Cys Ala Arg Glu Gln Ile Arg Glu Ala Thr Ser 
225                 230                 235                 240 


Glu Arg Lys Asp Leu Asn Ile His Val Arg Asp Thr Lys Thr Val Lys 
                245                 250                 255     


Asp Val Gln Lys Ala Lys Asn Val Asn Lys Thr Ala Glu Lys Val Arg 
            260                 265                 270         


Ile Ile Lys Tyr Leu Leu Gly Glu Leu Lys Ala Leu Val Ala Glu Gln 
        275                 280                 285             


Glu Asp Ser Glu Ile Gln Arg Leu Ile Thr Glu Met Glu Ala Cys Ile 
    290                 295                 300                 


Ser Val Leu Pro Thr Val Ser Gly Asn Thr Asp Ile Gln Val Glu Ile 
305                 310                 315                 320 


Ala Leu Ala Met Gln Pro Leu Arg Ser Glu Asn Ala Gln Leu Arg Arg 
                325                 330                 335     


Gln Leu Arg Ile Leu Asn Gln Gln Leu Arg Glu Gln Gln Lys Thr Gln 
            340                 345                 350         


Lys Pro Ser Gly Ala Val Asp Cys Asn Leu Glu Leu Phe Ser Leu Gln 
        355                 360                 365             


Ser Leu Asn Met Ser Leu Gln Asn Gln Leu Glu Glu Ser Leu Lys Ser 
    370                 375                 380                 


Gln Glu Leu Leu Gln Ser Lys Asn Glu Glu Leu Leu Lys Val Ile Glu 
385                 390                 395                 400 


Asn Gln Lys Asp Glu Asn Lys Lys Phe Ser Ser Ile Phe Lys Asp Lys 
                405                 410                 415     


Asp Gln Thr Ile Leu Glu Asn Lys Gln Gln Tyr Asp Ile Glu Ile Thr 
            420                 425                 430         


Arg Ile Lys Ile Glu Leu Glu Glu Ala Leu Val Asn Val Lys Ser Ser 
        435                 440                 445             


Gln Phe Lys Leu Glu Thr Ala Glu Lys Glu Asn Gln Ile Leu Gly Ile 
    450                 455                 460                 


Thr Leu Arg Gln Arg Asp Ala Glu Val Thr Arg Leu Arg Glu Leu Thr 
465                 470                 475                 480 


Arg Thr Leu Gln Thr Ser Met Ala Lys Leu Leu Ser Asp Leu Ser Val 
                485                 490                 495     


Asp Ser Ala Arg Cys Lys Pro Gly Asn Asn Leu Thr Lys Ser Leu Leu 
            500                 505                 510         


Asn Ile His Asp Lys Gln Leu Gln His Asp Pro Ala Pro Ala His Thr 
        515                 520                 525             


Ser Ile Met Ser Tyr Leu Asn Lys Leu Glu Thr Asn Tyr Ser Phe Thr 
    530                 535                 540                 


His Ser Glu Pro Leu Ser Thr Ile Lys Asn Glu Glu Thr Ile Glu Pro 
545                 550                 555                 560 


Asp Lys Thr Tyr Glu Asn Val Leu Ser Ser Arg Gly Pro Gln Asn Ser 
                565                 570                 575     


Asn Thr Arg Gly Met Glu Glu Ala Ser Ala Pro Gly Ile Ile Ser Ala 
            580                 585                 590         


Leu Ser Lys Gln Asp Ser Asp Glu Gly Ser Glu Thr Met Ala Leu Ile 
        595                 600                 605             


Glu Asp Glu His Asn Leu Asp Asn Thr Ile Tyr Ile Pro Phe Ala Arg 
    610                 615                 620                 


Ser Thr Pro Glu Lys Lys Ser Pro Leu Ser Lys Arg Leu Ser Pro Gln 
625                 630                 635                 640 


Pro Gln Ile Arg Ala Ala Thr Thr Gln Leu Val Ser Asn Ser Gly Leu 
                645                 650                 655     


Ala Val Ser Gly Lys Glu Asn Lys Leu Cys Thr Pro Val Ile Cys Ser 
            660                 665                 670         


Ser Ser Thr Lys Glu Ala Glu Asp Ala Pro Glu Lys Leu Ser Arg Ala 
        675                 680                 685             


Ser Asp Met Lys Asp Thr Gln Leu Leu Lys Lys Ile Lys Glu Ala Ile 
    690                 695                 700                 


Gly Lys Ile Pro Ala Ala Thr Lys Glu Pro Glu Glu Gln Thr Ala Cys 
705                 710                 715                 720 


His Gly Pro Ser Gly Cys Leu Ser Asn Ser Leu Gln Val Lys Gly Asn 
                725                 730                 735     


Thr Val Cys Asp Gly Ser Val Phe Thr Ser Asp Leu Met Ser Asp Trp 
            740                 745                 750         


Ser Ile Ser Ser Phe Ser Thr Phe Thr Ser Arg Asp Glu Gln Asp Phe 
        755                 760                 765             


Arg Asn Gly Leu Ala Ala Leu Asp Ala Asn Ile Ala Arg Leu Gln Lys 
    770                 775                 780                 


Ser Leu Arg Thr Gly Leu Leu Glu Lys 
785                 790             


<210> 5312
<211> 372
<212> PRT
<213> Homo sapiens

<400> 5312
Met Thr Phe Gln Phe Asn Phe Thr Ile Glu Asp His Leu Glu Asn Glu 
1               5                   10                  15      


Leu Thr Pro Ile Arg Asp Gly Ala Leu Thr Leu Asp Ser Ser Lys Glu 
            20                  25                  30          


Leu Ser Val Ser Glu Ser Gln Lys Gly Glu Glu Arg Asp Arg Lys Cys 
        35                  40                  45              


Ser Ala Glu Gln Phe Asp Leu Pro Gln Asp His Leu Trp Glu His Lys 
    50                  55                  60                  


Ser Met Glu Asn Ala Ala Pro Ser Gln Asp Thr Asp Ser Pro Leu Ser 
65                  70                  75                  80  


Ala Ala Ser Ser Ser Arg Asn Leu Glu Pro His Gly Lys Gln Pro Ser 
                85                  90                  95      


Leu Arg Ala Ala Lys Glu His Ala Met Pro Lys Asp Leu Lys Lys Met 
            100                 105                 110         


Leu Glu Asn Lys Val Ile Glu Thr Leu Pro Gly Phe Gln His Val Lys 
        115                 120                 125             


Leu Ser Val Val Lys Thr Ile Leu Leu Lys Glu Asn Phe Pro Gly Glu 
    130                 135                 140                 


Asn Ile Val Ser Lys Ser Phe Ser Ser His Ser Asp Leu Ile Thr Gly 
145                 150                 155                 160 


Val Tyr Glu Gly Gly Leu Lys Ile Trp Glu Cys Thr Phe Asp Leu Leu 
                165                 170                 175     


Ala Tyr Phe Thr Lys Ala Lys Val Lys Phe Ala Gly Lys Lys Val Leu 
            180                 185                 190         


Asp Leu Gly Cys Gly Ser Gly Leu Leu Gly Ile Thr Ala Phe Lys Gly 
        195                 200                 205             


Gly Ser Lys Glu Ile His Phe Gln Asp Tyr Asn Ser Met Val Ile Asp 
    210                 215                 220                 


Glu Val Thr Leu Pro Asn Val Val Ala Asn Ser Thr Leu Glu Asp Glu 
225                 230                 235                 240 


Glu Asn Asp Val Asn Glu Pro Asp Val Lys Arg Cys Arg Lys Pro Lys 
                245                 250                 255     


Val Thr Gln Leu Tyr Lys Cys Arg Phe Phe Ser Gly Glu Trp Ser Glu 
            260                 265                 270         


Phe Cys Lys Leu Val Leu Ser Ser Glu Lys Leu Phe Val Lys Tyr Asp 
        275                 280                 285             


Leu Ile Leu Thr Ser Glu Thr Ile Tyr Asn Pro Asp Tyr Tyr Ser Asn 
    290                 295                 300                 


Leu His Gln Thr Phe Leu Arg Leu Leu Ser Lys Asn Gly Arg Val Leu 
305                 310                 315                 320 


Leu Ala Ser Lys Ala His Tyr Phe Gly Val Gly Gly Gly Val His Leu 
                325                 330                 335     


Phe Gln Lys Phe Val Glu Glu Arg Asp Val Phe Lys Thr Arg Ile Leu 
            340                 345                 350         


Lys Ile Ile Asp Glu Gly Leu Lys Arg Phe Ile Ile Glu Ile Thr Phe 
        355                 360                 365             


Lys Phe Pro Gly 
    370         


<210> 5313
<211> 111
<212> PRT
<213> Homo sapiens

<400> 5313
Met Thr Thr Leu Arg Ala Phe Thr Cys Asp Asp Leu Phe Arg Phe Asn 
1               5                   10                  15      


Asn Ile Asn Leu Asp Pro Leu Thr Glu Thr Tyr Gly Ile Pro Phe Tyr 
            20                  25                  30          


Leu Gln Tyr Leu Ala His Trp Pro Glu Tyr Phe Ile Val Ala Glu Ala 
        35                  40                  45              


Pro Gly Gly Glu Leu Met Gly Tyr Ile Met Gly Lys Ala Glu Gly Ser 
    50                  55                  60                  


Val Ala Arg Glu Glu Trp His Gly His Val Thr Ala Leu Ser Val Ala 
65                  70                  75                  80  


Pro Glu Phe Arg Arg Leu Gly Leu Ala Ala Lys Leu Met Glu Leu Leu 
                85                  90                  95      


Glu Glu Ile Ser Glu Arg Tyr Glu Glu Ser Thr Phe Gln Gly Tyr 
            100                 105                 110     


<210> 5314
<211> 482
<212> PRT
<213> Homo sapiens

<400> 5314
Met Asn Gly Thr Leu Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu 
            20                  25                  30          


Arg Glu Leu Phe Glu Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Met Lys Val Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Asn Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Ile Ser Lys Lys Cys Thr Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Ser Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Thr Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Thr Ala Ile Lys Ala Met His Gln Ala Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Met Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Lys Arg Met Ala Gln Gln Leu Gln Gln Gln Met Gln Gln Ile 
        195                 200                 205             


Ser Ala Ala Ser Val Trp Gly Asn Leu Ala Gly Leu Asn Thr Leu Gly 
    210                 215                 220                 


Pro Gln Tyr Leu Ala Leu Leu Gln Gln Thr Ala Ser Ser Gly Asn Leu 
225                 230                 235                 240 


Asn Thr Leu Ser Ser Leu His Pro Met Gly Gly Leu Asn Ala Met Gln 
                245                 250                 255     


Leu Gln Asn Leu Ala Ala Leu Ala Ala Ala Ala Ser Ala Ala Gln Asn 
            260                 265                 270         


Thr Pro Ser Gly Thr Asn Ala Leu Thr Thr Ser Ser Ser Pro Leu Ser 
        275                 280                 285             


Val Leu Thr Ser Ser Gly Ser Ser Pro Ser Ser Ser Ser Ser Asn Ser 
    290                 295                 300                 


Val Asn Pro Ile Ala Ser Leu Gly Ala Leu Gln Thr Leu Ala Gly Ala 
305                 310                 315                 320 


Thr Ala Gly Leu Asn Val Gly Ser Leu Ala Gly Met Ala Ala Leu Asn 
                325                 330                 335     


Gly Gly Leu Gly Ser Ser Gly Leu Ser Asn Gly Thr Gly Ser Thr Met 
            340                 345                 350         


Glu Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala 
        355                 360                 365             


Ala Leu Pro Thr Leu Tyr Asn Gln Asn Leu Leu Thr Gln Gln Ser Ile 
    370                 375                 380                 


Gly Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe 
385                 390                 395                 400 


Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln Asp Leu Leu Gln Met 
                405                 410                 415     


Phe Met Pro Phe Gly Asn Val Val Ser Ala Lys Val Phe Ile Asp Lys 
            420                 425                 430         


Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro 
        435                 440                 445             


Val Ser Ala Gln Ala Ala Ile Gln Ser Met Asn Gly Phe Gln Ile Gly 
    450                 455                 460                 


Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys 
465                 470                 475                 480 


Pro Tyr 
        


<210> 5315
<211> 448
<212> PRT
<213> Homo sapiens

<400> 5315
Met Ser Pro Leu Glu Cys Ser Glu Cys Phe Gly Asp Gln Leu Leu His 
1               5                   10                  15      


Arg Thr Tyr Thr Trp Gln Leu Thr Leu His Ser Arg Pro Asn Tyr Thr 
            20                  25                  30          


Arg Lys Arg Asp Thr Arg Ser Glu Ser Leu Glu Ile Pro Ile Ser Val 
        35                  40                  45              


Val Leu Pro Gln Arg Gly Thr Ala Glu Pro Phe Pro Arg Leu His Asn 
    50                  55                  60                  


Leu Tyr Ser Thr Pro Arg Cys Ala Gln Gln Ala Ala Leu Pro Arg Leu 
65                  70                  75                  80  


Ser Arg Arg Met Ala Ser Gln His Ser Tyr Pro Leu Asn Arg Phe Ser 
                85                  90                  95      


Ser Val Pro Leu Asp Pro Met Glu Arg Pro Met Ser Gln Ala Asp Leu 
            100                 105                 110         


Glu Leu Asp Tyr Asn Pro Pro Arg Val Gln Leu Ser Asp Glu Met Phe 
        115                 120                 125             


Val Phe Gln Asp Gly Arg Trp Val Asn Glu Asn Cys Arg Leu Gln Ser 
    130                 135                 140                 


Pro Tyr Phe Ser Pro Ser Ala Ser Phe His His Lys Leu His His Lys 
145                 150                 155                 160 


Arg Leu Ala Lys Glu Cys Met Leu Gln Glu Glu Asn Lys Ser Leu Arg 
                165                 170                 175     


Glu Glu Asn Lys Ala Leu Arg Glu Glu Asn Arg Met Leu Ser Lys Glu 
            180                 185                 190         


Asn Lys Ile Leu Gln Val Phe Trp Glu Glu His Lys Ala Ser Leu Gly 
        195                 200                 205             


Arg Glu Glu Ser Arg Ala Pro Ser Pro Leu Leu His Lys Asp Ser Ala 
    210                 215                 220                 


Ser Leu Glu Val Val Lys Lys Asp His Val Ala Leu Gln Val Pro Arg 
225                 230                 235                 240 


Gly Lys Glu Asp Ser Thr Leu Gln Leu Leu Arg Glu Glu Asn Arg Ala 
                245                 250                 255     


Leu Gln Gln Leu Leu Glu Gln Lys Gln Ala Tyr Trp Ala Gln Ala Glu 
            260                 265                 270         


Asp Thr Ala Ala Pro Ala Glu Glu Ser Lys Pro Ala Pro Ser Pro His 
        275                 280                 285             


Glu Glu Pro Cys Ser Pro Gly Leu Leu Gln Asp Gln Gly Ser Gly Leu 
    290                 295                 300                 


Ser Ser Arg Phe Glu Glu Pro Lys Gly Pro Pro Ala Arg Gln Glu Asp 
305                 310                 315                 320 


Ser Lys Glu Leu Arg Ala Leu Arg Lys Met Val Ser Asn Met Ser Gly 
                325                 330                 335     


Pro Ser Gly Glu Glu Glu Ala Lys Val Gly Pro Gly Leu Pro Asp Gly 
            340                 345                 350         


Cys Gln Pro Leu Gln Leu Leu Arg Glu Met Arg Gln Ala Leu Gln Ala 
        355                 360                 365             


Leu Leu Lys Glu Asn Arg Leu Leu Gln Glu Glu Asn Arg Thr Leu Gln 
    370                 375                 380                 


Val Leu Arg Ala Glu His Arg Gly Phe Gln Glu Glu Asn Lys Ala Leu 
385                 390                 395                 400 


Trp Glu Asn Asn Lys Leu Lys Leu Gln Gln Lys Leu Val Ile Asp Thr 
                405                 410                 415     


Val Thr Glu Val Thr Ala Arg Met Glu Met Leu Ile Glu Glu Leu Tyr 
            420                 425                 430         


Ala Phe Met Pro Ala Arg Ser Gln Asp Pro Lys Lys Pro Ser Arg Val 
        435                 440                 445             


<210> 5316
<211> 333
<212> PRT
<213> Homo sapiens

<400> 5316
Met Ala Ala Ala Ala Ala Gly Thr Ala Thr Ser Gln Arg Phe Phe Gln 
1               5                   10                  15      


Ser Phe Ser Asp Ala Leu Ile Asp Glu Asp Pro Gln Ala Ala Leu Glu 
            20                  25                  30          


Glu Leu Thr Lys Ala Leu Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr 
        35                  40                  45              


Cys Gln Arg Ala Tyr Cys His Ile Leu Leu Gly Asn Tyr Cys Val Ala 
    50                  55                  60                  


Val Ala Asp Ala Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr 
65                  70                  75                  80  


Ala Met Leu Arg Lys Gly Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala 
                85                  90                  95      


Ala Ala Leu Glu Thr Phe Thr Glu Gly Gln Lys Leu Asp Ser Ala Asp 
            100                 105                 110         


Ala Asn Phe Ser Val Trp Ile Lys Arg Cys Gln Glu Ala Gln Asn Gly 
        115                 120                 125             


Ser Glu Ser Glu Val Trp Thr His Gln Ser Lys Ile Lys Tyr Asp Trp 
    130                 135                 140                 


Tyr Gln Thr Glu Ser Gln Val Val Ile Thr Leu Met Ile Lys Asn Val 
145                 150                 155                 160 


Gln Lys Asn Asp Val Asn Val Glu Phe Ser Glu Lys Glu Leu Ser Ala 
                165                 170                 175     


Leu Val Lys Leu Pro Ser Gly Glu Asp Tyr Asn Leu Lys Leu Glu Leu 
            180                 185                 190         


Leu His Pro Ile Ile Pro Glu Gln Ser Thr Phe Lys Val Leu Ser Thr 
        195                 200                 205             


Lys Ile Glu Ile Lys Leu Lys Lys Pro Glu Ala Val Arg Trp Glu Lys 
    210                 215                 220                 


Leu Glu Gly Gln Gly Asp Val Pro Thr Pro Lys Gln Phe Val Ala Asp 
225                 230                 235                 240 


Val Lys Asn Leu Tyr Pro Ser Ser Ser Pro Tyr Thr Arg Asn Trp Asp 
                245                 250                 255     


Lys Leu Val Gly Glu Ile Lys Glu Glu Glu Lys Asn Glu Lys Leu Glu 
            260                 265                 270         


Gly Asp Ala Ala Leu Asn Arg Leu Phe Gln Gln Ile Tyr Ser Asp Gly 
        275                 280                 285             


Ser Asp Glu Val Lys Arg Ala Met Asn Lys Ser Phe Met Glu Ser Gly 
    290                 295                 300                 


Gly Thr Val Leu Ser Thr Asn Trp Ser Asp Val Gly Lys Arg Lys Val 
305                 310                 315                 320 


Glu Ile Asn Pro Pro Asp Asp Met Glu Trp Lys Lys Tyr 
                325                 330             


<210> 5317
<211> 342
<212> PRT
<213> Homo sapiens

<400> 5317
Met Ser Leu His Gly Lys Arg Lys Glu Ile Tyr Lys Tyr Glu Ala Pro 
1               5                   10                  15      


Trp Thr Val Tyr Ala Met Asn Trp Ser Val Arg Pro Asp Lys Arg Phe 
            20                  25                  30          


Arg Leu Ala Leu Gly Ser Phe Val Glu Glu Tyr Asn Asn Lys Val Gln 
        35                  40                  45              


Leu Val Gly Leu Asp Glu Glu Ser Ser Glu Phe Ile Cys Arg Asn Thr 
    50                  55                  60                  


Phe Asp His Pro Tyr Pro Thr Thr Lys Leu Met Trp Ile Pro Asp Thr 
65                  70                  75                  80  


Lys Gly Val Tyr Pro Asp Leu Leu Ala Thr Ser Gly Asp Tyr Leu Arg 
                85                  90                  95      


Val Trp Arg Val Gly Glu Thr Glu Thr Arg Leu Glu Cys Leu Leu Asn 
            100                 105                 110         


Asn Asn Lys Asn Ser Asp Phe Cys Ala Pro Leu Thr Ser Phe Asp Trp 
        115                 120                 125             


Asn Glu Val Asp Pro Tyr Leu Leu Gly Thr Ser Ser Ile Asp Thr Thr 
    130                 135                 140                 


Cys Thr Ile Trp Gly Leu Glu Thr Gly Gln Val Leu Gly Arg Val Asn 
145                 150                 155                 160 


Leu Val Ser Gly His Val Lys Thr Gln Leu Ile Ala His Asp Lys Glu 
                165                 170                 175     


Val Tyr Asp Ile Ala Phe Ser Arg Ala Gly Gly Gly Arg Asp Met Phe 
            180                 185                 190         


Ala Ser Val Gly Ala Asp Gly Ser Val Arg Met Phe Asp Leu Arg His 
        195                 200                 205             


Leu Glu His Ser Thr Ile Ile Tyr Glu Asp Pro Gln His His Pro Leu 
    210                 215                 220                 


Leu Arg Leu Cys Trp Asn Lys Gln Asp Pro Asn Tyr Leu Ala Thr Met 
225                 230                 235                 240 


Ala Met Asp Gly Met Glu Val Val Ile Leu Asp Val Arg Val Pro Cys 
                245                 250                 255     


Thr Pro Val Ala Arg Leu Asn Asn His Arg Ala Cys Val Asn Gly Ile 
            260                 265                 270         


Ala Trp Ala Pro His Ser Ser Cys His Ile Cys Thr Ala Ala Asp Asp 
        275                 280                 285             


His Gln Ala Leu Ile Trp Asp Ile Gln Gln Met Pro Arg Ala Ile Glu 
    290                 295                 300                 


Asp Pro Ile Leu Ala Tyr Thr Ala Glu Gly Glu Ile Asn Asn Val Gln 
305                 310                 315                 320 


Trp Ala Ser Thr Gln Pro Asp Trp Ile Ala Ile Cys Tyr Asn Asn Cys 
                325                 330                 335     


Leu Glu Ile Leu Arg Val 
            340         


<210> 5318
<211> 168
<212> PRT
<213> Homo sapiens

<400> 5318
Met Ala Glu Gly Ser Arg Ile Pro Gln Ala Arg Ala Leu Leu Gln Gln 
1               5                   10                  15      


Cys Leu His Ala Arg Leu Gln Ile Arg Pro Ala Asp Gly Asp Val Ala 
            20                  25                  30          


Ala Gln Trp Val Glu Val Gln Arg Gly Leu Val Ile Tyr Val Cys Phe 
        35                  40                  45              


Phe Lys Gly Ala Asp Lys Glu Leu Leu Pro Lys Met Val Asn Thr Leu 
    50                  55                  60                  


Leu Asn Val Lys Leu Ser Glu Thr Glu Asn Gly Lys His Val Ser Ile 
65                  70                  75                  80  


Leu Asp Leu Pro Gly Asn Ile Leu Ile Ile Pro Gln Ala Thr Leu Gly 
                85                  90                  95      


Gly Arg Leu Lys Gly Arg Asn Met Gln Tyr His Ser Asn Ser Gly Lys 
            100                 105                 110         


Glu Glu Gly Phe Glu Leu Tyr Ser Gln Phe Val Thr Leu Cys Glu Lys 
        115                 120                 125             


Glu Val Ala Ala Asn Ser Lys Cys Ala Glu Ala Arg Val Val Val Glu 
    130                 135                 140                 


His Gly Thr Tyr Gly Asn Arg Gln Val Leu Lys Leu Asp Thr Asn Gly 
145                 150                 155                 160 


Pro Phe Thr His Leu Ile Glu Phe 
                165             


<210> 5319
<211> 1022
<212> PRT
<213> Homo sapiens

<400> 5319
Met Glu Gly Ala Leu Thr Ala Arg Asp Lys Val Gly Val Gln Asp Phe 
1               5                   10                  15      


Val Leu Leu Asp Ala Tyr Thr Ser Glu Ser Ala Phe Val Asp Asn Leu 
            20                  25                  30          


Arg Lys Arg Phe Ser Glu Asn Leu Ile Tyr Thr Tyr Ile Gly Thr Leu 
        35                  40                  45              


Leu Val Ser Val Asn Pro Tyr Gln Glu Leu Gly Ile Tyr Thr Val Ser 
    50                  55                  60                  


Gln Met Glu Leu Tyr Gln Gly Val Asn Phe Phe Glu Leu Pro Pro His 
65                  70                  75                  80  


Val Tyr Ala Ile Ala Asp Asn Ala Tyr Arg Met Met Cys Ala Glu Leu 
                85                  90                  95      


Asn Asn His Phe Ile Leu Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr 
            100                 105                 110         


Glu Ala Ser Lys Lys Ile Leu Glu Tyr Phe Ala Val Thr Cys Pro Met 
        115                 120                 125             


Thr Gln Ser Leu Gln Ile Ala Arg Asp Arg Leu Leu Phe Ser Asn Pro 
    130                 135                 140                 


Val Leu Glu Ala Phe Gly Asn Ala Arg Thr Leu Arg Asn Asp Asn Ser 
145                 150                 155                 160 


Ser Arg Phe Gly Lys Tyr Met Asp Ile Gln Phe Asp Phe Gln Gly Ile 
                165                 170                 175     


Pro Val Gly Gly His Ile Ile Ser Tyr Leu Ile Glu Lys Ser Arg Val 
            180                 185                 190         


Val Tyr Gln Asn Glu Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu 
        195                 200                 205             


Leu Ala Gly Gly Glu Glu Glu Arg Leu Ser Tyr Leu Gly Leu Glu Arg 
    210                 215                 220                 


Asp Pro Gln Leu Tyr Lys Tyr Leu Ser Gln Gly His Cys Ala Lys Glu 
225                 230                 235                 240 


Ser Ser Ile Ser Asp Lys Asn Asp Trp Lys Thr Val Ser Asn Ala Phe 
                245                 250                 255     


Ser Val Ile Asp Phe Thr Glu Ala Asp Leu Glu Asn Leu Phe Gly Ile 
            260                 265                 270         


Ile Ala Ser Val Leu His Leu Gly Asn Ile Gly Phe Glu Glu Asp Asp 
        275                 280                 285             


Gln Gly Cys Ala Thr Ile Pro Asp Thr His Glu Ile Lys Trp Ile Ala 
    290                 295                 300                 


Lys Leu Leu Gly Val His Pro Ser Val Leu Leu Glu Ala Leu Thr His 
305                 310                 315                 320 


Arg Lys Ile Glu Ala Lys Thr Glu Glu Val Ile Cys Pro Leu Thr Leu 
                325                 330                 335     


Glu Leu Ser Val Tyr Ala Arg Asp Ala Met Ala Lys Ala Val Tyr Gly 
            340                 345                 350         


Arg Thr Phe Thr Trp Leu Val Asn Lys Ile Asn Ser Ser Leu Val Asn 
        355                 360                 365             


Lys Asp Phe Thr Arg Lys Thr Val Ile Gly Leu Leu Asp Ile Tyr Gly 
    370                 375                 380                 


Phe Glu Val Phe Asp Lys Asn Gly Phe Glu Gln Phe Cys Ile Asn Tyr 
385                 390                 395                 400 


Cys Asn Glu Lys Leu Gln Gln Leu Leu Ile Glu Arg Thr Leu Lys Ala 
                405                 410                 415     


Glu Gln Ala Glu Tyr Glu Met Glu Gly Ile Glu Trp Glu Pro Ile Lys 
            420                 425                 430         


Tyr Phe Asn Asn Lys Ile Ile Cys Asp Leu Val Glu Glu Arg His Lys 
        435                 440                 445             


Gly Ile Ile Ser Ile Leu Asp Glu Glu Cys Ile Arg Pro Gly Pro Ala 
    450                 455                 460                 


Thr Asp Leu Ser Phe Leu Glu Lys Leu Glu Glu Lys Val Gly Lys His 
465                 470                 475                 480 


Ala His Phe Glu Thr Arg Lys Leu Ala Gly Pro Lys Gly Arg Lys Arg 
                485                 490                 495     


Ile Gly Trp Met Glu Phe Arg Leu Leu His Tyr Ala Gly Glu Val Thr 
            500                 505                 510         


Tyr Cys Thr Lys Gly Phe Leu Glu Lys Asn Asn Asp Leu Leu Tyr Arg 
        515                 520                 525             


His Leu Lys Glu Val Leu Cys Lys Ser Lys Asn Ile Ile Leu Arg Glu 
    530                 535                 540                 


Cys Phe Leu Leu Ala Glu Leu Glu Asn Arg Arg Arg Pro Pro Thr Val 
545                 550                 555                 560 


Gly Thr Gln Phe Lys Asn Ser Leu Ser Ser Leu Leu Glu Thr Leu Ile 
                565                 570                 575     


Ser Lys Glu Pro Ser Tyr Ile Arg Cys Ile Lys Pro Asn Asp Arg Lys 
            580                 585                 590         


Glu Pro Ser Lys Phe Asp Asp Phe Leu Ile Arg His Gln Ile Lys Tyr 
        595                 600                 605             


Leu Gly Leu Met Glu His Leu Arg Val Arg Arg Ala Gly Phe Ala Tyr 
    610                 615                 620                 


Arg Arg Lys Tyr Glu His Phe Leu Gln Arg Tyr Lys Ser Leu Cys Pro 
625                 630                 635                 640 


Asp Thr Trp Pro His Trp His Gly Pro Pro Ala Glu Gly Val Glu Arg 
                645                 650                 655     


Leu Ile Lys Tyr Ile Gly Tyr Lys Pro Glu Glu Tyr Lys Leu Gly Lys 
            660                 665                 670         


Thr Lys Ile Phe Ile Arg Phe Pro Arg Thr Leu Phe Ala Thr Glu Asp 
        675                 680                 685             


Ala Phe Glu Phe Ser Lys His Gln Leu Val Ala Arg Ile Gln Ala Thr 
    690                 695                 700                 


Tyr Lys Arg Cys Leu Gly Arg Arg Glu Tyr Val Lys Lys Arg Gln Ala 
705                 710                 715                 720 


Ala Ile Lys Leu Glu Ala His Trp Arg Gly Ala Leu Ala Arg Lys Ala 
                725                 730                 735     


Ile Gln Arg Arg Lys Trp Ala Val Arg Ile Ile Arg Lys Phe Ile Lys 
            740                 745                 750         


Gly Phe Ile Ser Arg Asn Lys Pro Leu Cys Pro Asp Asn Glu Glu Phe 
        755                 760                 765             


Ile Val Phe Val Arg Lys Asn Tyr Ile Leu Asn Leu Arg Tyr His Leu 
    770                 775                 780                 


Pro Lys Thr Val Leu Asp Lys Ser Trp Leu Arg Pro Pro Gly Ile Leu 
785                 790                 795                 800 


Glu Asn Ala Ser Asp Leu Leu Arg Lys Met Cys Val Arg Asn Leu Val 
                805                 810                 815     


Gln Lys Tyr Cys Arg Gly Ile Thr Ala Glu Arg Lys Ala Met Met Gln 
            820                 825                 830         


Gln Lys Val Val Thr Ser Glu Ile Phe Arg Gly Arg Lys Asp Gly Tyr 
        835                 840                 845             


Thr Glu Ser Leu Asn Gln Pro Phe Val Asn Ser Arg Ile Asp Glu Gly 
    850                 855                 860                 


Asp Ile Asn Pro Lys Val Leu Gln Leu Ile Ser His Glu Lys Ile Gln 
865                 870                 875                 880 


Tyr Gly Val Pro Val Ile Lys Tyr Asp Arg Lys Gly Phe Lys Ala Arg 
                885                 890                 895     


Gln Arg Gln Leu Ile Leu Thr Gln Lys Ala Ala Tyr Val Val Glu Leu 
            900                 905                 910         


Ala Lys Ile Lys Gln Lys Ile Glu Tyr Ser Ala Leu Lys Gly Val Ser 
        915                 920                 925             


Thr Ser Asn Leu Ser Asp Gly Ile Leu Val Ile His Val Ser Pro Glu 
    930                 935                 940                 


Asp Ser Lys Gln Lys Gly Asp Ala Val Leu Gln Cys Gly His Val Phe 
945                 950                 955                 960 


Glu Ala Val Thr Lys Leu Val Met Leu Val Lys Lys Glu Asn Ile Val 
                965                 970                 975     


Asn Val Val Gln Gly Ser Leu Gln Phe Phe Ile Ser Pro Gly Lys Glu 
            980                 985                 990         


Gly Thr Ile Val Phe Asp Thr Gly  Leu Glu Glu Gln Val  Tyr Lys Asn 
        995                 1000                 1005             


Lys Asn  Gly Gln Leu Thr Val  Val Ser Val Arg Arg  Lys Ser 
    1010                 1015                 1020         


<210> 5320
<211> 347
<212> PRT
<213> Homo sapiens

<400> 5320
Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp Val Glu 
1               5                   10                  15      


Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Cys Asp Val Ser Trp 
            20                  25                  30          


Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val Arg Ile 
        35                  40                  45              


Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr Met Val 
    50                  55                  60                  


Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala Gly Lys 
65                  70                  75                  80  


Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu Met Pro 
                85                  90                  95      


Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro Gly Ile 
            100                 105                 110         


Thr Trp Ile Met Lys Pro Val Ala Arg Ser Gln Gly Lys Gly Ile Phe 
        115                 120                 125             


Leu Phe Arg Arg Leu Lys Asp Ile Val Asp Trp Arg Lys Asp Thr Arg 
    130                 135                 140                 


Ser Ser Asp Asp Gln Lys Asp Asp Ile Pro Val Glu Asn Tyr Val Ala 
145                 150                 155                 160 


Gln Arg Tyr Ile Glu Asn Pro Tyr Leu Ile Gly Gly Arg Lys Phe Asp 
                165                 170                 175     


Leu Arg Val Tyr Val Leu Val Met Ser Tyr Ile Pro Leu Arg Ala Trp 
            180                 185                 190         


Leu Tyr Arg Asp Gly Phe Ala Arg Phe Ser Asn Thr Arg Phe Thr Leu 
        195                 200                 205             


Asn Ser Ile Asp Asp Gln Tyr Val His Leu Thr Asn Val Ala Val Gln 
    210                 215                 220                 


Lys Thr Ser Pro Asp Tyr His Pro Lys Lys Gly Cys Lys Trp Thr Leu 
225                 230                 235                 240 


Gln Arg Phe Arg Gln Tyr Leu Ala Ser Lys His Gly Pro Glu Ala Val 
                245                 250                 255     


Glu Thr Leu Phe Arg Asp Ile Asp Asn Ile Phe Val Lys Ser Leu Gln 
            260                 265                 270         


Ser Val Gln Lys Val Ile Ile Ser Asp Lys His Cys Phe Glu Leu Tyr 
        275                 280                 285             


Gly Tyr Asp Ile Leu Ile Asp Gln Asp Leu Lys Pro Trp Leu Leu Glu 
    290                 295                 300                 


Val Asn Ala Ser Pro Ser Leu Thr Ala Ser Ser Gln Glu Asp Tyr Glu 
305                 310                 315                 320 


Leu Lys Thr Cys Leu Leu Glu Asp Thr Leu His Val Val Asp Met Glu 
                325                 330                 335     


Ala Arg Ser Leu Arg Ala Asp Ser Pro Cys Trp 
            340                 345         


<210> 5321
<211> 147
<212> PRT
<213> Homo sapiens

<400> 5321
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Thr His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Thr Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Thr Arg Arg Thr 
        35                  40                  45              


Arg Thr Phe Ser Ala Thr Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Thr 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Asp Val Glu 
                85                  90                  95      


Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Thr Tyr Lys Met Cys 
            100                 105                 110         


Ser Ile Pro Pro Lys Asn Glu Lys Leu Gln Ala Val Glu Val Val Ile 
        115                 120                 125             


Thr His Leu Ala Pro Gly Thr Lys His Glu Thr Trp Ser Gly His Val 
    130                 135                 140                 


Ile Ser Ser 
145         


<210> 5322
<211> 185
<212> PRT
<213> Homo sapiens

<400> 5322
Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 
        35                  40                  45              


Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 
    50                  55                  60                  


Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro 
65                  70                  75                  80  


Ala Tyr Gln Asn Leu Arg Gln Lys Val Asp Asn Phe Val Ser Thr His 
                85                  90                  95      


Leu Asp Lys Gln Glu Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg 
            100                 105                 110         


Asn Gly Leu Arg Gln Ser Val Val Gln Ser Gly Met Leu Glu Ala Gly 
        115                 120                 125             


Val Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Leu Asn His Ile 
    130                 135                 140                 


Phe Arg Pro Gln Ile Glu Arg Ala Ile His Glu Phe Leu Ala Ala Gln 
145                 150                 155                 160 


Lys Lys Ala Ala Val Pro Ala Pro Pro Pro Glu Pro Glu Gly Gln Asp 
                165                 170                 175     


Pro Pro Ala Pro Ser Gln Asp Thr Ser 
            180                 185 


<210> 5323
<211> 2116
<212> PRT
<213> Homo sapiens

<400> 5323
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu 
            100                 105                 110         


Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser 
    130                 135                 140                 


Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln 
145                 150                 155                 160 


Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser 
                165                 170                 175     


Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu 
            180                 185                 190         


Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val 
        195                 200                 205             


Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu 
    210                 215                 220                 


Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu 
225                 230                 235                 240 


Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser 
                245                 250                 255     


Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser 
            260                 265                 270         


Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser 
        275                 280                 285             


Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His 
    290                 295                 300                 


Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu 
305                 310                 315                 320 


Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn 
                325                 330                 335     


Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val 
            340                 345                 350         


Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu 
        355                 360                 365             


Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu 
    370                 375                 380                 


Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met 
385                 390                 395                 400 


Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu 
                405                 410                 415     


Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala 
            420                 425                 430         


Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala 
        435                 440                 445             


Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr 
    450                 455                 460                 


Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn 
465                 470                 475                 480 


Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Asn Val Leu Ala 
                485                 490                 495     


Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu Gln 
            500                 505                 510         


Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys Arg 
        515                 520                 525             


Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu Tyr 
    530                 535                 540                 


Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro Ser 
545                 550                 555                 560 


Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly Leu 
                565                 570                 575     


Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu Leu 
            580                 585                 590         


Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys Leu 
        595                 600                 605             


Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu Asp 
    610                 615                 620                 


Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln Arg 
625                 630                 635                 640 


His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu Lys 
                645                 650                 655     


Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu Ala 
            660                 665                 670         


His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu Gln 
        675                 680                 685             


Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg Leu 
    690                 695                 700                 


Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala Ser 
705                 710                 715                 720 


Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu Glu 
                725                 730                 735     


Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu Gln 
            740                 745                 750         


Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu Arg 
        755                 760                 765             


Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg Glu 
    770                 775                 780                 


Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala Gln 
785                 790                 795                 800 


Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala Leu 
                805                 810                 815     


Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln Glu 
            820                 825                 830         


Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu Leu 
        835                 840                 845             


Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu Lys 
    850                 855                 860                 


Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met Leu 
865                 870                 875                 880 


Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg Gln 
                885                 890                 895     


Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr Gln 
            900                 905                 910         


Gln Ser Leu Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His Lys 
        915                 920                 925             


Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala Ser 
    930                 935                 940                 


Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His Asp 
945                 950                 955                 960 


Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn Ile 
                965                 970                 975     


His Lys Ala Thr Cys Glu Thr Ala Asp Arg Glu Arg Ala Glu Met Ser 
            980                 985                 990         


Thr Glu Ile Ser Arg Leu Gln Ser  Lys Ile Lys Glu Met  Gln Gln Ala 
        995                 1000                 1005             


Thr Ser  Pro Leu Ser Met Leu  Gln Ser Gly Cys Gln  Val Ile Gly 
    1010                 1015                 1020             


Glu Glu  Glu Val Glu Gly Asp  Gly Ala Leu Ser Leu  Leu Gln Gln 
    1025                 1030                 1035             


Gly Glu  Gln Leu Leu Glu Glu  Asn Gly Asp Val Leu  Leu Ser Leu 
    1040                 1045                 1050             


Gln Arg  Ala His Glu Gln Ala  Val Lys Glu Asn Val  Lys Met Ala 
    1055                 1060                 1065             


Thr Glu  Ile Ser Arg Leu Gln  Gln Arg Leu Gln Lys  Leu Glu Pro 
    1070                 1075                 1080             


Gly Leu  Val Met Ser Ser Cys  Leu Asp Glu Pro Ala  Thr Glu Phe 
    1085                 1090                 1095             


Phe Gly  Asn Thr Ala Glu Gln  Thr Glu Gln Phe Leu  Gln Gln Asn 
    1100                 1105                 1110             


Arg Thr  Lys Gln Val Glu Gly  Val Thr Arg Arg His  Val Leu Ser 
    1115                 1120                 1125             


Asp Leu  Glu Asp Asp Glu Val  Arg Asp Leu Gly Ser  Thr Gly Thr 
    1130                 1135                 1140             


Ser Ser  Val Gln Arg Gln Glu  Val Lys Ile Glu Glu  Ser Glu Ala 
    1145                 1150                 1155             


Ser Val  Glu Gly Phe Ser Glu  Leu Glu Asn Ser Glu  Glu Thr Arg 
    1160                 1165                 1170             


Thr Glu  Ser Trp Glu Leu Lys  Asn Gln Ile Ser Gln  Leu Gln Glu 
    1175                 1180                 1185             


Gln Leu  Met Met Leu Cys Ala  Asp Cys Asp Arg Ala  Ser Glu Lys 
    1190                 1195                 1200             


Lys Gln  Asp Leu Leu Phe Asp  Val Ser Val Leu Lys  Lys Lys Leu 
    1205                 1210                 1215             


Lys Met  Leu Glu Arg Ile Pro  Glu Ala Ser Pro Lys  Tyr Lys Leu 
    1220                 1225                 1230             


Leu Tyr  Glu Asp Val Ser Arg  Glu Asn Asp Cys Leu  Gln Glu Glu 
    1235                 1240                 1245             


Leu Arg  Met Met Glu Thr Arg  Tyr Asp Glu Ala Leu  Glu Asn Asn 
    1250                 1255                 1260             


Lys Glu  Leu Thr Ala Glu Val  Phe Arg Leu Gln Asp  Glu Leu Lys 
    1265                 1270                 1275             


Lys Met  Glu Glu Val Thr Glu  Thr Phe Leu Ser Leu  Glu Lys Ser 
    1280                 1285                 1290             


Tyr Asp  Glu Val Lys Ile Glu  Asn Glu Gly Leu Asn  Val Leu Val 
    1295                 1300                 1305             


Leu Arg  Leu Gln Gly Lys Ile  Glu Lys Leu Gln Glu  Ser Val Val 
    1310                 1315                 1320             


Gln Arg  Cys Asp Cys Cys Leu  Trp Glu Ala Ser Leu  Glu Asn Leu 
    1325                 1330                 1335             


Glu Ile  Glu Pro Asp Gly Asn  Ile Leu Gln Leu Asn  Gln Thr Leu 
    1340                 1345                 1350             


Glu Glu  Cys Val Pro Arg Val  Arg Ser Val His His  Val Ile Glu 
    1355                 1360                 1365             


Glu Cys  Lys Gln Glu Asn Gln  Tyr Leu Glu Gly Asn  Thr Gln Leu 
    1370                 1375                 1380             


Leu Glu  Lys Val Lys Ala His  Glu Ile Ala Trp Leu  His Gly Thr 
    1385                 1390                 1395             


Ile Gln  Thr His Gln Glu Arg  Pro Arg Val Gln Asn  Gln Val Ile 
    1400                 1405                 1410             


Leu Glu  Glu Asn Thr Thr Leu  Leu Gly Phe Gln Asp  Lys His Phe 
    1415                 1420                 1425             


Gln His  Gln Ala Thr Ile Ala  Glu Leu Glu Leu Glu  Lys Thr Lys 
    1430                 1435                 1440             


Leu Gln  Glu Leu Thr Arg Lys  Leu Lys Glu Arg Val  Thr Ile Leu 
    1445                 1450                 1455             


Val Lys  Gln Lys Asp Val Leu  Ser His Gly Glu Lys  Glu Glu Glu 
    1460                 1465                 1470             


Leu Lys  Ala Met Met His Asp  Leu Gln Ile Thr Cys  Ser Glu Met 
    1475                 1480                 1485             


Gln Gln  Lys Val Glu Leu Leu  Arg Tyr Glu Ser Glu  Lys Leu Gln 
    1490                 1495                 1500             


Gln Glu  Asn Ser Ile Leu Arg  Asn Glu Ile Thr Thr  Leu Asn Glu 
    1505                 1510                 1515             


Glu Asp  Ser Ile Ser Asn Leu  Lys Leu Gly Thr Leu  Asn Gly Ser 
    1520                 1525                 1530             


Gln Glu  Glu Met Trp Gln Lys  Thr Glu Thr Val Lys  Gln Glu Asn 
    1535                 1540                 1545             


Ala Ala  Val Gln Lys Met Val  Glu Asn Leu Lys Lys  Gln Ile Ser 
    1550                 1555                 1560             


Glu Leu  Lys Ile Lys Asn Gln  Gln Leu Asp Leu Glu  Asn Thr Glu 
    1565                 1570                 1575             


Leu Ser  Gln Lys Asn Ser Gln  Asn Gln Glu Lys Leu  Gln Glu Leu 
    1580                 1585                 1590             


Asn Gln  Arg Leu Thr Glu Met  Leu Cys Gln Lys Glu  Lys Glu Pro 
    1595                 1600                 1605             


Gly Asn  Ser Ala Leu Glu Glu  Arg Glu Gln Glu Lys  Phe Asn Leu 
    1610                 1615                 1620             


Lys Glu  Glu Leu Glu Arg Cys  Lys Val Gln Ser Ser  Thr Leu Val 
    1625                 1630                 1635             


Ser Ser  Leu Glu Ala Glu Leu  Ser Glu Val Lys Ile  Gln Thr His 
    1640                 1645                 1650             


Ile Val  Gln Gln Glu Asn His  Leu Leu Lys Asp Glu  Leu Glu Lys 
    1655                 1660                 1665             


Met Lys  Gln Leu His Arg Cys  Pro Asp Leu Ser Asp  Phe Gln Gln 
    1670                 1675                 1680             


Lys Ile  Ser Ser Val Leu Ser  Tyr Asn Glu Lys Leu  Leu Lys Glu 
    1685                 1690                 1695             


Lys Glu  Ala Leu Ser Glu Glu  Leu Asn Ser Cys Val  Asp Lys Leu 
    1700                 1705                 1710             


Ala Lys  Ser Ser Leu Leu Glu  His Arg Ile Ala Thr  Met Lys Gln 
    1715                 1720                 1725             


Glu Gln  Lys Ser Trp Glu His  Gln Ser Ala Ser Leu  Lys Ser Gln 
    1730                 1735                 1740             


Leu Val  Ala Ser Gln Glu Lys  Val Gln Asn Leu Glu  Asp Thr Val 
    1745                 1750                 1755             


Gln Asn  Val Asn Leu Gln Met  Ser Arg Met Lys Ser  Asp Leu Arg 
    1760                 1765                 1770             


Val Thr  Gln Gln Glu Lys Glu  Ala Leu Lys Gln Glu  Val Met Ser 
    1775                 1780                 1785             


Leu His  Lys Gln Leu Gln Asn  Ala Gly Gly Lys Ser  Trp Ala Pro 
    1790                 1795                 1800             


Glu Ile  Ala Thr His Pro Ser  Gly Leu His Asn Gln  Gln Lys Arg 
    1805                 1810                 1815             


Leu Ser  Trp Asp Lys Leu Asp  His Leu Met Asn Glu  Glu Gln Gln 
    1820                 1825                 1830             


Leu Leu  Trp Gln Glu Asn Glu  Arg Leu Gln Thr Met  Val Gln Asn 
    1835                 1840                 1845             


Thr Lys  Ala Glu Leu Thr His  Ser Arg Glu Lys Val  Arg Gln Leu 
    1850                 1855                 1860             


Glu Ser  Asn Leu Leu Pro Lys  His Gln Lys His Leu  Asn Pro Ser 
    1865                 1870                 1875             


Gly Thr  Met Asn Pro Thr Glu  Gln Glu Lys Leu Ser  Leu Lys Arg 
    1880                 1885                 1890             


Glu Cys  Asp Gln Phe Gln Lys  Glu Gln Ser Pro Ala  Asn Arg Lys 
    1895                 1900                 1905             


Val Ser  Gln Met Asn Ser Leu  Glu Gln Glu Leu Glu  Thr Ile His 
    1910                 1915                 1920             


Leu Glu  Asn Glu Gly Leu Lys  Lys Lys Gln Val Lys  Leu Asp Glu 
    1925                 1930                 1935             


Gln Leu  Met Glu Met Gln His  Leu Arg Ser Thr Ala  Thr Pro Ser 
    1940                 1945                 1950             


Pro Ser  Pro His Ala Trp Asp  Leu Gln Leu Leu Gln  Gln Gln Ala 
    1955                 1960                 1965             


Cys Pro  Met Val Pro Arg Glu  Gln Phe Leu Gln Leu  Gln Arg Gln 
    1970                 1975                 1980             


Leu Leu  Gln Ala Glu Arg Ile  Asn Gln His Leu Gln  Glu Glu Leu 
    1985                 1990                 1995             


Glu Asn  Arg Thr Ser Glu Thr  Asn Thr Pro Gln Gly  Asn Gln Glu 
    2000                 2005                 2010             


Gln Leu  Val Thr Val Met Glu  Glu Arg Met Ile Glu  Val Glu Gln 
    2015                 2020                 2025             


Lys Leu  Lys Leu Val Lys Arg  Leu Leu Gln Glu Lys  Val Asn Gln 
    2030                 2035                 2040             


Leu Lys  Glu Gln Leu Cys Lys  Asn Thr Lys Ala Asp  Ala Met Val 
    2045                 2050                 2055             


Lys Asp  Leu Tyr Val Glu Asn  Ala Gln Leu Leu Lys  Ala Leu Glu 
    2060                 2065                 2070             


Val Thr  Glu Gln Arg Gln Lys  Thr Ala Glu Lys Lys  Asn Tyr Leu 
    2075                 2080                 2085             


Leu Glu  Glu Lys Ile Ala Ser  Leu Ser Asn Ile Val  Arg Asn Leu 
    2090                 2095                 2100             


Thr Pro  Ala Pro Leu Thr Ser  Thr Pro Pro Leu Arg  Ser 
    2105                 2110                 2115     


<210> 5324
<211> 887
<212> PRT
<213> Homo sapiens

<400> 5324
Met Pro Ile Leu Leu Phe Leu Ile Asp Thr Ser Ala Ser Met Asn Gln 
1               5                   10                  15      


Arg Ser His Leu Gly Thr Thr Tyr Leu Asp Thr Ala Lys Gly Ala Val 
            20                  25                  30          


Glu Thr Phe Met Lys Leu Arg Ala Arg Asp Pro Ala Ser Arg Gly Asp 
        35                  40                  45              


Arg Tyr Met Leu Val Thr Phe Glu Glu Pro Pro Tyr Ala Ile Lys Ala 
    50                  55                  60                  


Gly Trp Lys Glu Asn His Ala Thr Phe Met Asn Glu Leu Lys Asn Leu 
65                  70                  75                  80  


Gln Ala Glu Gly Leu Thr Thr Leu Gly Gln Ser Leu Arg Thr Ala Phe 
                85                  90                  95      


Asp Leu Leu Asn Leu Asn Arg Leu Val Thr Gly Ile Asp Asn Tyr Gly 
            100                 105                 110         


Gln Gly Arg Asn Pro Phe Phe Leu Glu Pro Ala Ile Ile Ile Thr Ile 
        115                 120                 125             


Thr Asp Gly Ser Lys Leu Thr Thr Thr Ser Gly Val Gln Asp Glu Leu 
    130                 135                 140                 


His Leu Pro Leu Asn Ser Pro Leu Pro Gly Ser Glu Leu Thr Lys Glu 
145                 150                 155                 160 


Pro Phe Arg Trp Asp Gln Arg Leu Phe Ala Leu Val Leu Arg Leu Pro 
                165                 170                 175     


Gly Thr Met Ser Val Glu Ser Glu Gln Leu Thr Gly Val Pro Leu Asp 
            180                 185                 190         


Asp Ser Ala Ile Thr Pro Met Cys Glu Val Thr Gly Gly Arg Ser Tyr 
        195                 200                 205             


Ser Val Cys Ser Pro Arg Met Leu Asn Gln Cys Leu Glu Ser Leu Val 
    210                 215                 220                 


Gln Lys Val Gln Ser Gly Val Val Ile Asn Phe Glu Lys Ala Gly Pro 
225                 230                 235                 240 


Asp Pro Ser Pro Val Glu Asp Gly Gln Pro Asp Ile Ser Arg Pro Phe 
                245                 250                 255     


Gly Ser Gln Pro Trp His Ser Cys His Lys Leu Ile Tyr Val Arg Pro 
            260                 265                 270         


Asn Pro Lys Thr Gly Val Pro Ile Gly His Trp Pro Val Pro Glu Ser 
        275                 280                 285             


Phe Trp Pro Asp Gln Asn Ser Pro Thr Leu Pro Pro Arg Thr Ser His 
    290                 295                 300                 


Pro Val Val Lys Phe Ser Cys Thr Asp Cys Glu Pro Met Val Ile Asp 
305                 310                 315                 320 


Lys Leu Pro Phe Asp Lys Tyr Glu Leu Glu Pro Ser Pro Leu Thr Gln 
                325                 330                 335     


Phe Ile Leu Glu Arg Lys Ser Pro Gln Thr Cys Trp Gln Val Tyr Val 
            340                 345                 350         


Ser Asn Ser Ala Lys Tyr Ser Glu Leu Gly His Pro Phe Gly Tyr Leu 
        355                 360                 365             


Lys Ala Ser Thr Ala Leu Asn Cys Val Asn Leu Phe Val Met Pro Tyr 
    370                 375                 380                 


Asn Tyr Pro Val Leu Leu Pro Leu Leu Asp Asp Leu Phe Lys Val His 
385                 390                 395                 400 


Lys Ala Lys Pro Thr Leu Lys Trp Arg Gln Ser Phe Glu Ser Tyr Leu 
                405                 410                 415     


Lys Thr Met Pro Pro Tyr Tyr Leu Gly Pro Leu Lys Lys Ala Val Arg 
            420                 425                 430         


Met Met Gly Ala Pro Asn Leu Ile Ala Asp Ser Met Glu Tyr Gly Leu 
        435                 440                 445             


Ser Tyr Ser Val Ile Ser Tyr Leu Lys Lys Leu Ser Gln Gln Ala Lys 
    450                 455                 460                 


Ile Glu Ser Asp Arg Val Ile Gly Ser Val Gly Lys Lys Val Val Gln 
465                 470                 475                 480 


Glu Thr Gly Ile Lys Val Arg Ser Arg Ser His Gly Leu Ser Met Ala 
                485                 490                 495     


Tyr Arg Lys Asp Phe Gln Gln Leu Leu Gln Gly Ile Ser Glu Asp Val 
            500                 505                 510         


Pro His Arg Leu Leu Asp Leu Asn Met Lys Glu Tyr Thr Gly Phe Gln 
        515                 520                 525             


Val Ala Leu Leu Asn Lys Asp Leu Lys Pro Gln Thr Phe Arg Asn Ala 
    530                 535                 540                 


Tyr Asp Ile Pro Arg Arg Asn Leu Leu Asp His Leu Thr Arg Met Arg 
545                 550                 555                 560 


Ser Asn Leu Leu Lys Ser Thr Arg Arg Phe Leu Lys Gly Gln Asp Glu 
                565                 570                 575     


Asp Gln Val His Ser Val Pro Ile Ala Gln Met Gly Asn Tyr Gln Glu 
            580                 585                 590         


Tyr Leu Lys Gln Val Pro Ser Pro Leu Arg Glu Leu Asp Pro Asp Gln 
        595                 600                 605             


Pro Arg Arg Leu His Thr Phe Gly Asn Pro Phe Lys Leu Asp Lys Lys 
    610                 615                 620                 


Gly Met Met Ile Asp Glu Ala Asp Glu Phe Val Ala Gly Pro Gln Asn 
625                 630                 635                 640 


Lys His Lys Arg Pro Gly Glu Pro Asn Met Gln Gly Ile Pro Lys Arg 
                645                 650                 655     


Arg Arg Cys Met Ser Pro Leu Leu Arg Gly Arg Gln Gln Asn Pro Val 
            660                 665                 670         


Val Asn Asn His Ile Gly Gly Lys Gly Pro Pro Ala Pro Thr Thr Gln 
        675                 680                 685             


Ala Gln Pro Asp Leu Ile Lys Pro Leu Pro Leu His Lys Ile Ser Glu 
    690                 695                 700                 


Thr Thr Asn Asp Ser Ile Ile His Asp Val Val Glu Asn His Val Ala 
705                 710                 715                 720 


Asp Gln Leu Ser Ser Asp Ile Thr Pro Asn Ala Met Asp Thr Glu Phe 
                725                 730                 735     


Ser Ala Ser Ser Pro Ala Ser Leu Leu Glu Arg Pro Thr Asn His Met 
            740                 745                 750         


Glu Ala Leu Gly His Asp His Leu Gly Thr Asn Asp Leu Thr Val Gly 
        755                 760                 765             


Gly Phe Leu Glu Asn His Glu Glu Pro Arg Asp Lys Glu Gln Cys Ala 
    770                 775                 780                 


Glu Glu Asn Ile Pro Ala Ser Ser Leu Asn Lys Gly Lys Lys Leu Met 
785                 790                 795                 800 


His Cys Arg Ser His Glu Glu Val Asn Thr Glu Leu Lys Ala Gln Ile 
                805                 810                 815     


Met Lys Glu Ile Arg Lys Pro Gly Arg Lys Tyr Glu Arg Ile Phe Thr 
            820                 825                 830         


Leu Leu Lys His Val Gln Gly Ser Leu Gln Thr Arg Leu Ile Phe Leu 
        835                 840                 845             


Gln Asn Val Ile Lys Glu Ala Ser Arg Phe Lys Lys Arg Met Leu Ile 
    850                 855                 860                 


Glu Gln Leu Glu Asn Phe Leu Asp Glu Ile His Arg Arg Ala Asn Gln 
865                 870                 875                 880 


Ile Asn His Ile Asn Ser Asn 
                885         


<210> 5325
<211> 647
<212> PRT
<213> Homo sapiens

<400> 5325
Met Ser Asp Glu Val Phe Ser Thr Thr Leu Ala Tyr Thr Lys Ser Pro 
1               5                   10                  15      


Lys Val Thr Lys Arg Thr Thr Phe Gln Asp Glu Leu Ile Arg Ala Ile 
            20                  25                  30          


Thr Ala Arg Ser Ala Arg Gln Arg Ser Ser Glu Tyr Ser Asp Asp Phe 
        35                  40                  45              


Asp Ser Asp Glu Ile Val Ser Leu Gly Asp Phe Ser Asp Thr Ser Ala 
    50                  55                  60                  


Asp Glu Asn Ser Val Asn Lys Lys Met Asn Asp Phe His Ile Ser Asp 
65                  70                  75                  80  


Asp Glu Glu Lys Asn Pro Ser Lys Leu Leu Phe Leu Lys Thr Asn Lys 
                85                  90                  95      


Ser Asn Gly Asn Ile Thr Lys Asp Glu Pro Val Cys Ala Ile Lys Asn 
            100                 105                 110         


Glu Glu Glu Met Ala Pro Asp Gly Cys Glu Asp Ile Val Val Lys Ser 
        115                 120                 125             


Phe Ser Glu Ser Gln Asn Lys Asp Glu Glu Phe Glu Lys Asp Lys Ile 
    130                 135                 140                 


Lys Met Lys Pro Lys Pro Arg Ile Leu Ser Ile Lys Ser Thr Ser Ser 
145                 150                 155                 160 


Ala Glu Asn Asn Ser Leu Asp Thr Asp Asp His Phe Lys Pro Ser Pro 
                165                 170                 175     


Arg Pro Arg Ser Met Leu Lys Lys Lys Ser His Met Glu Glu Lys Asp 
            180                 185                 190         


Gly Leu Glu Asp Lys Glu Thr Ala Leu Ser Glu Glu Leu Glu Leu His 
        195                 200                 205             


Ser Ala Pro Ser Ser Leu Pro Thr Pro Asn Gly Ile Gln Leu Glu Ala 
    210                 215                 220                 


Glu Lys Lys Ala Phe Ser Glu Asn Leu Asp Pro Glu Asp Ser Cys Leu 
225                 230                 235                 240 


Thr Ser Leu Ala Ser Ser Ser Leu Lys Gln Ile Leu Gly Asp Ser Phe 
                245                 250                 255     


Ser Pro Gly Ser Glu Gly Asn Ala Ser Gly Lys Asp Pro Asn Glu Glu 
            260                 265                 270         


Ile Thr Glu Asn His Asn Ser Leu Lys Ser Asp Glu Asn Lys Glu Asn 
        275                 280                 285             


Ser Phe Ser Ala Asp His Val Thr Thr Ala Val Glu Lys Ser Lys Glu 
    290                 295                 300                 


Ser Gln Val Thr Ala Asp Asp Leu Glu Glu Glu Lys Ala Lys Ala Glu 
305                 310                 315                 320 


Leu Ile Met Asp Asp Asp Arg Thr Val Asp Pro Leu Leu Ser Lys Ser 
                325                 330                 335     


Gln Ser Ile Leu Ile Ser Thr Ser Ala Thr Ala Ser Ser Lys Lys Thr 
            340                 345                 350         


Ile Glu Asp Arg Asn Ile Lys Asn Lys Lys Ser Thr Asn Asn Arg Ala 
        355                 360                 365             


Ser Ser Ala Ser Ala Arg Leu Met Thr Ser Glu Phe Leu Lys Lys Ser 
    370                 375                 380                 


Ser Ser Lys Arg Arg Thr Pro Ser Thr Thr Thr Ser Ser His Tyr Leu 
385                 390                 395                 400 


Gly Thr Leu Lys Val Leu Asp Gln Lys Pro Ser Gln Lys Gln Ser Ile 
                405                 410                 415     


Glu Pro Asp Arg Ala Asp Asn Ile Arg Ala Ala Val Tyr Gln Glu Trp 
            420                 425                 430         


Leu Glu Lys Lys Asn Val Tyr Leu His Glu Met His Arg Ile Lys Arg 
        435                 440                 445             


Ile Glu Ser Glu Asn Leu Arg Ile Gln Asn Glu Gln Lys Lys Ala Ala 
    450                 455                 460                 


Lys Arg Glu Glu Ala Leu Ala Ser Phe Glu Ala Trp Lys Ala Met Lys 
465                 470                 475                 480 


Glu Lys Glu Ala Lys Lys Ile Ala Ala Lys Lys Arg Leu Glu Glu Lys 
                485                 490                 495     


Asn Lys Lys Lys Thr Glu Glu Glu Asn Ala Ala Arg Lys Gly Glu Ala 
            500                 505                 510         


Leu Gln Ala Phe Glu Lys Trp Lys Glu Lys Lys Met Glu Tyr Leu Lys 
        515                 520                 525             


Glu Lys Asn Arg Lys Glu Arg Glu Tyr Glu Arg Ala Lys Lys Gln Lys 
    530                 535                 540                 


Glu Glu Glu Thr Val Ala Glu Lys Lys Lys Asp Asn Leu Thr Ala Val 
545                 550                 555                 560 


Glu Lys Trp Asn Glu Lys Lys Glu Ala Phe Phe Lys Gln Lys Glu Lys 
                565                 570                 575     


Glu Lys Ile Asn Glu Lys Arg Lys Glu Glu Leu Lys Arg Ala Glu Lys 
            580                 585                 590         


Lys Asp Lys Asp Lys Gln Ala Ile Asn Glu Tyr Glu Lys Trp Leu Glu 
        595                 600                 605             


Asn Lys Glu Lys Gln Glu Arg Ile Glu Arg Lys Gln Lys Lys Arg His 
    610                 615                 620                 


Ser Phe Leu Glu Ser Glu Ala Leu Pro Pro Trp Ser Pro Pro Ser Arg 
625                 630                 635                 640 


Thr Val Phe Ala Lys Val Phe 
                645         


<210> 5326
<211> 357
<212> PRT
<213> Homo sapiens

<400> 5326
Met Gln Thr Phe Leu Lys Gly Lys Arg Val Gly Tyr Trp Leu Ser Glu 
1               5                   10                  15      


Lys Lys Ile Lys Lys Leu Asn Phe Gln Ala Phe Ala Glu Leu Cys Arg 
            20                  25                  30          


Lys Arg Gly Met Glu Val Val Gln Leu Asn Leu Ser Arg Pro Ile Glu 
        35                  40                  45              


Glu Gln Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile 
    50                  55                  60                  


Leu Glu Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg 
65                  70                  75                  80  


Phe Gln Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro 
                85                  90                  95      


Leu Pro Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu 
            100                 105                 110         


Ile Arg Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro 
        115                 120                 125             


Pro Phe Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu 
    130                 135                 140                 


Leu Glu Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val 
145                 150                 155                 160 


Ala His Gly Thr Asn Ser His Glu Met Ala Ile Val Phe Asn Gln Glu 
                165                 170                 175     


Gly Leu Asn Ala Ile Gln Pro Pro Cys Val Val Gln Asn Phe Ile Asn 
            180                 185                 190         


His Asn Ala Val Leu Tyr Lys Val Phe Val Val Gly Glu Ser Tyr Thr 
        195                 200                 205             


Val Val Gln Arg Pro Ser Leu Lys Asn Phe Ser Ala Gly Thr Ser Asp 
    210                 215                 220                 


Arg Glu Ser Ile Phe Phe Asn Ser His Asn Val Ser Lys Pro Glu Ser 
225                 230                 235                 240 


Ser Ser Val Leu Thr Glu Leu Asp Lys Ile Glu Gly Val Phe Glu Arg 
                245                 250                 255     


Pro Ser Asp Glu Val Ile Arg Glu Leu Ser Arg Ala Leu Arg Gln Ala 
            260                 265                 270         


Leu Gly Val Ser Leu Phe Gly Ile Asp Ile Ile Ile Asn Asn Gln Thr 
        275                 280                 285             


Gly Gln His Ala Val Ile Asp Ile Asn Ala Phe Pro Gly Tyr Glu Gly 
    290                 295                 300                 


Val Ser Glu Phe Phe Thr Asp Leu Leu Asn His Ile Ala Thr Val Leu 
305                 310                 315                 320 


Gln Gly Gln Ser Thr Ala Met Ala Ala Pro Ser Gly Glu Phe Arg Ala 
                325                 330                 335     


Gly Asp Leu Cys Cys Asp Leu Gly Lys Ser Phe Gln Val Phe Gly Pro 
            340                 345                 350         


Pro Pro Pro Cys Leu 
        355         


<210> 5327
<211> 283
<212> PRT
<213> Homo sapiens

<400> 5327
Met Leu Arg Cys Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg 
1               5                   10                  15      


His Leu Gly Arg Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp 
            20                  25                  30          


Ser Tyr Phe Ser Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr 
        35                  40                  45              


Tyr Ser Ile His Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser 
    50                  55                  60                  


Ile Gly Gln Trp Tyr Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys 
65                  70                  75                  80  


Leu Ala Val Phe Asp Thr Trp Ser Ser Leu Ala Val His Ile Ala Met 
                85                  90                  95      


Asp Asn Thr Val Val Met Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser 
            100                 105                 110         


Val Pro Cys Ala Gly Ala Thr Ala Phe Pro Ala Asp Ser Asp Arg His 
        115                 120                 125             


Cys Asn Gly Phe Pro Ala Gly Ala Glu Val Thr Asn Arg Pro Ser Pro 
    130                 135                 140                 


Trp Arg Pro Leu Val Leu Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp 
145                 150                 155                 160 


Ile Asn Glu Ala Tyr Val Glu Thr Leu Lys His Cys Phe Met Met Pro 
                165                 170                 175     


Gln Ser Leu Gly Val Ile Gly Gly Lys Pro Asn Ser Ala His Tyr Phe 
            180                 185                 190         


Ile Gly Tyr Val Gly Glu Glu Leu Ile Tyr Leu Asp Pro His Thr Thr 
        195                 200                 205             


Gln Pro Ala Val Glu Pro Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser 
    210                 215                 220                 


Phe His Cys Gln His Pro Pro Cys Arg Met Ser Ile Ala Glu Leu Asp 
225                 230                 235                 240 


Pro Ser Ile Ala Val Val Leu Gly Val Gly Lys Gln Gly Arg Leu Val 
                245                 250                 255     


Arg Ser Ile Pro Trp Ala Pro Arg Pro Ser Ser Trp Cys Ala Ala Val 
            260                 265                 270         


Leu Gly Ala Ala Val Val Met Cys Gly Thr Pro 
        275                 280             


<210> 5328
<211> 719
<212> PRT
<213> Homo sapiens

<400> 5328
Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg 
1               5                   10                  15      


Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe 
            20                  25                  30          


Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys 
        35                  40                  45              


Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln 
    50                  55                  60                  


Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys Glu Val His Gln Thr 
65                  70                  75                  80  


Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln 
                85                  90                  95      


Gln His Val Gln Leu Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn 
            100                 105                 110         


Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu 
        115                 120                 125             


Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn 
    130                 135                 140                 


Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met 
145                 150                 155                 160 


Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro 
                165                 170                 175     


His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys 
            180                 185                 190         


Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu 
        195                 200                 205             


Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile 
    210                 215                 220                 


Leu Phe Thr Lys Ala Glu Asp Asn Lys Tyr Leu Leu Thr Cys Lys Thr 
225                 230                 235                 240 


Ala Arg Gln Leu Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala 
                245                 250                 255     


Pro Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val 
            260                 265                 270         


Leu Gly Lys Cys Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro 
        275                 280                 285             


Ile Glu Arg Glu Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu 
    290                 295                 300                 


Pro Ser Ile Gln Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu 
305                 310                 315                 320 


Val Gly Asn Met Thr Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu 
                325                 330                 335     


Glu Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu 
            340                 345                 350         


Leu Pro Lys Gly Val Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe 
        355                 360                 365             


Pro Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu 
    370                 375                 380                 


Leu Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys 
385                 390                 395                 400 


Thr Pro Ala Gln Ser Thr His Ser Glu Ala Pro Pro Ser Lys Met Val 
                405                 410                 415     


Leu Arg Ile Pro His Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val 
            420                 425                 430         


Pro Gly Val Pro Pro Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser 
        435                 440                 445             


Pro Ala Ala Leu Pro Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val 
465                 470                 475                 480 


Met Met Pro Ser Pro Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg 
                485                 490                 495     


Arg Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys 
            500                 505                 510         


Pro Ala Pro Val Ile His Pro Ala Ser Val Ile Phe Thr Val Pro Ala 
        515                 520                 525             


Thr Thr Val Lys Ile Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln 
    530                 535                 540                 


Pro Val Asn Ala Ala Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala 
545                 550                 555                 560 


Thr Leu Leu Val Asn Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro 
                565                 570                 575     


Leu Val Ala Ser Ser Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val 
            580                 585                 590         


Asn Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys Ala His Met Asn Val 
        595                 600                 605             


Asp Ile Ala Cys Ala Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu 
    610                 615                 620                 


Glu Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val 
625                 630                 635                 640 


Phe Pro Lys Val Glu His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln 
                645                 650                 655     


Cys Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val 
            660                 665                 670         


Lys Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile 
        675                 680                 685             


Gln Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val 
    690                 695                 700                 


Lys Met Glu Pro Glu Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
705                 710                 715                 


<210> 5329
<211> 377
<212> PRT
<213> Homo sapiens

<400> 5329
Met Glu Ala Ala Ala Val Thr Val Thr Arg Ser Ala Thr Arg Arg Arg 
1               5                   10                  15      


Arg Arg Gln Leu Gln Gly Leu Ala Ala Pro Glu Ala Gly Thr Gln Glu 
            20                  25                  30          


Glu Gln Glu Asp Gln Glu Pro Arg Pro Arg Arg Arg Arg Pro Gly Arg 
        35                  40                  45              


Ser Ile Lys Asp Glu Glu Glu Glu Thr Val Phe Arg Glu Val Val Ser 
    50                  55                  60                  


Phe Ser Pro Asp Pro Leu Pro Val Arg Tyr Tyr Asp Lys Asp Thr Thr 
65                  70                  75                  80  


Lys Pro Ile Ser Phe Tyr Leu Ser Ser Leu Glu Glu Leu Leu Ala Trp 
                85                  90                  95      


Lys Pro Arg Leu Glu Asp Gly Phe Asn Val Ala Leu Glu Pro Leu Ala 
            100                 105                 110         


Cys Arg Gln Pro Pro Leu Ser Ser Gln Arg Pro Arg Thr Leu Leu Cys 
        115                 120                 125             


His Asp Met Met Gly Gly Tyr Leu Asp Asp Arg Phe Ile Gln Gly Ser 
    130                 135                 140                 


Val Val Gln Thr Pro Tyr Ala Phe Tyr His Trp Gln Cys Ile Asp Val 
145                 150                 155                 160 


Phe Val Tyr Phe Ser His His Thr Val Thr Ile Pro Pro Val Gly Trp 
                165                 170                 175     


Thr Asn Thr Ala His Arg His Gly Val Cys Val Leu Gly Thr Phe Ile 
            180                 185                 190         


Thr Glu Trp Asn Glu Gly Gly Arg Leu Cys Glu Ala Phe Leu Ala Gly 
        195                 200                 205             


Asp Glu Arg Ser Tyr Gln Ala Val Ala Asp Arg Leu Val Gln Ile Thr 
    210                 215                 220                 


Gln Phe Phe Arg Phe Asp Gly Trp Leu Ile Asn Ile Glu Asn Ser Leu 
225                 230                 235                 240 


Ser Leu Ala Ala Val Gly Asn Met Pro Pro Phe Leu Arg Tyr Leu Thr 
                245                 250                 255     


Thr Gln Leu His Arg Gln Val Pro Gly Gly Leu Val Leu Trp Tyr Asp 
            260                 265                 270         


Ser Val Val Gln Ser Gly Gln Leu Lys Trp Gln Asp Glu Leu Asn Gln 
        275                 280                 285             


His Asn Arg Val Phe Phe Asp Ser Cys Asp Gly Phe Phe Thr Asn Tyr 
    290                 295                 300                 


Asn Trp Arg Glu Glu His Leu Glu Arg Met Leu Gly Gln Ala Gly Glu 
305                 310                 315                 320 


Arg Arg Ala Asp Val Tyr Val Gly Val Asp Val Phe Ala Arg Gly Asn 
                325                 330                 335     


Val Val Gly Gly Arg Phe Asp Thr Asp Lys Ser Leu Glu Leu Ile Arg 
            340                 345                 350         


Lys His Gly Phe Ser Val Ala Leu Phe Ala Pro Gly Cys Ser Val Phe 
        355                 360                 365             


Pro Gly Val Gly Asn Leu Leu Cys Cys 
    370                 375         


<210> 5330
<211> 308
<212> PRT
<213> Homo sapiens

<400> 5330
Met Arg Gly Lys Arg Arg Pro Gln Thr Arg Ala Ala Arg Arg Leu Ala 
1               5                   10                  15      


Ala Gln Glu Ser Ser Glu Ala Glu Asp Met Ser Val Pro Arg Gly Pro 
            20                  25                  30          


Ile Ala Gln Trp Ala Asp Gly Ala Ile Ser Pro Asn Gly His Arg Pro 
        35                  40                  45              


Gln Leu Arg Ala Ala Ser Gly Glu Asp Ser Thr Glu Glu Ala Leu Ala 
    50                  55                  60                  


Ala Ala Ala Ala Pro Trp Glu Gly Gly Pro Val Pro Gly Val Asp Thr 
65                  70                  75                  80  


Ser Pro Phe Ala Lys Ser Leu Gly His Ser Arg Gly Glu Ala Asp Leu 
                85                  90                  95      


Phe Asp Ser Gly Asp Ile Phe Ser Thr Gly Thr Gly Ser Gln Ser Val 
            100                 105                 110         


Glu Arg Thr Lys Pro Lys Ala Lys Ile Ala Glu Asn Pro Ala Asn Pro 
        115                 120                 125             


Pro Val Gly Gly Lys Ala Lys Ser Pro Met Phe Pro Ala Leu Gly Glu 
    130                 135                 140                 


Ala Ser Ser Asp Asp Asp Leu Phe Gln Ser Ala Lys Pro Lys Pro Ala 
145                 150                 155                 160 


Lys Lys Thr Asn Pro Phe Pro Leu Leu Glu Asp Glu Asp Asp Leu Phe 
                165                 170                 175     


Thr Asp Gln Lys Val Lys Lys Asn Glu Thr Lys Ser Ser Ser Gln Gln 
            180                 185                 190         


Asp Val Ile Leu Thr Thr Gln Asp Ile Phe Glu Asp Asp Ile Phe Ala 
        195                 200                 205             


Thr Glu Ala Ile Lys Pro Ser Gln Lys Thr Arg Glu Lys Glu Lys Thr 
    210                 215                 220                 


Leu Glu Ser Asn Leu Phe Asp Asp Asn Ile Asp Ile Phe Ala Asp Leu 
225                 230                 235                 240 


Thr Val Lys Pro Lys Glu Lys Ser Lys Lys Lys Val Glu Ala Lys Ser 
                245                 250                 255     


Ile Phe Asp Asp Asp Met Asp Asp Ile Phe Ser Thr Gly Ile Gln Ala 
            260                 265                 270         


Lys Thr Thr Lys Pro Lys Ser Arg Ser Ala Gln Ala Ala Pro Glu Pro 
        275                 280                 285             


Arg Phe Glu His Lys Val Ser Asn Ile Phe Asp Asp Pro Leu Asn Ala 
    290                 295                 300                 


Phe Gly Gly Gln 
305             


<210> 5331
<211> 310
<212> PRT
<213> Homo sapiens

<400> 5331
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Phe Thr Glu Ile Ser His Arg Ile Leu Cys Ser Tyr 
225                 230                 235                 240 


Asn Thr Asn Ile Glu Glu Leu Phe Ala Glu Ile Asp Gln Cys Leu Ala 
                245                 250                 255     


Ile Asn Arg Ser Val Leu Gln Gln Leu Glu Glu Lys Cys Gly His Glu 
            260                 265                 270         


Ile Thr Glu Glu Glu Trp Glu Lys Ile Gln Val Gln Asn Glu Thr Ser 
        275                 280                 285             


Ala Cys Phe Glu Asp Pro Cys Leu Gly Ala His Gly Ser His Phe Ser 
    290                 295                 300                 


Leu Ser Asn Phe Leu Leu 
305                 310 


<210> 5332
<211> 372
<212> PRT
<213> Homo sapiens

<400> 5332
Met Arg Val Gly Pro Val Arg Ser Ala Met Ser Gly Ala Ser Gln Pro 
1               5                   10                  15      


Arg Gly Pro Ala Leu Leu Phe Pro Ala Thr Arg Gly Val Pro Ala Lys 
            20                  25                  30          


Arg Leu Leu Asp Ala Asp Asp Ala Ala Ala Val Ala Ala Lys Cys Pro 
        35                  40                  45              


Arg Leu Ser Glu Cys Ser Ser Pro Pro Asp Tyr Leu Ser Pro Pro Gly 
    50                  55                  60                  


Ser Pro Cys Ser Pro Gln Pro Pro Pro Ala Ala Pro Gly Ala Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Ser Ala Pro Gly Pro Ser Arg Ile Ala Asp Tyr Leu Leu 
                85                  90                  95      


Leu Pro Leu Ala Glu Arg Glu His Val Ser Arg Ala Leu Cys Ile His 
            100                 105                 110         


Thr Gly Arg Glu Leu Arg Cys Lys Val Phe Pro Ile Lys His Tyr Gln 
        115                 120                 125             


Asp Lys Ile Arg Pro Tyr Ile Gln Leu Pro Ser His Ser Asn Ile Thr 
    130                 135                 140                 


Gly Ile Val Glu Val Ile Leu Gly Glu Thr Lys Ala Tyr Val Phe Phe 
145                 150                 155                 160 


Glu Lys Asp Phe Gly Asp Met His Ser Tyr Val Arg Ser Arg Lys Arg 
                165                 170                 175     


Leu Arg Glu Glu Glu Ala Ala Arg Leu Phe Lys Gln Ile Val Ser Ala 
            180                 185                 190         


Val Ala His Cys His Gln Ser Ala Ile Val Leu Gly Asp Leu Lys Leu 
        195                 200                 205             


Arg Lys Phe Val Phe Ser Thr Glu Glu Arg Thr Gln Leu Arg Leu Glu 
    210                 215                 220                 


Ser Leu Glu Asp Thr His Ile Met Lys Gly Glu Asp Asp Ala Leu Ser 
225                 230                 235                 240 


Asp Lys His Gly Cys Pro Ala Tyr Val Ser Pro Glu Ile Leu Asn Thr 
                245                 250                 255     


Thr Gly Thr Tyr Ser Gly Lys Ala Ala Asp Val Trp Ser Leu Gly Val 
            260                 265                 270         


Met Leu Tyr Thr Leu Leu Val Gly Arg Tyr Pro Phe His Asp Ser Asp 
        275                 280                 285             


Pro Ser Ala Leu Phe Ser Lys Ile Arg Arg Gly Gln Phe Cys Ile Pro 
    290                 295                 300                 


Glu His Ile Ser Pro Lys Ala Arg Cys Leu Ile Arg Ser Leu Leu Arg 
305                 310                 315                 320 


Arg Glu Pro Ser Glu Arg Leu Thr Ala Pro Glu Ile Leu Leu His Pro 
                325                 330                 335     


Trp Phe Glu Ser Val Leu Glu Pro Gly Tyr Ile Asp Ser Glu Ile Gly 
            340                 345                 350         


Thr Ser Asp Gln Ile Val Pro Glu Tyr Gln Glu Asp Ser Asp Ile Ser 
        355                 360                 365             


Ser Phe Phe Cys 
    370         


<210> 5333
<211> 517
<212> PRT
<213> Homo sapiens

<400> 5333
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Ser Ser Ser Arg Leu Ser Tyr Gln 
            260                 265                 270         


Pro Ala Ala Leu Gly Val Gly Ser Ala Asp Leu Ala Tyr Pro Val Val 
        275                 280                 285             


Phe Ala Ala Gly Leu Asn Ala Thr His Pro His Gln Leu Met Val Pro 
    290                 295                 300                 


Gly Lys Glu Gly Gly Val Pro Leu Ala Pro Asn Gln Pro Val His Gly 
305                 310                 315                 320 


Thr Gln Ala Asp Gln Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg 
                325                 330                 335     


Thr His Cys Ala Ala Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val 
            340                 345                 350         


Ser Asn Ser Ser Glu Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr 
        355                 360                 365             


Ile Phe Val Arg Lys Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln 
    370                 375                 380                 


Val Thr Leu Thr Ser Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys 
385                 390                 395                 400 


Asn Leu Glu Leu Glu Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser 
                405                 410                 415     


Pro Glu Thr Glu Ser Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser 
            420                 425                 430         


Ser Gly Gly Ser Ser Gly Asn Thr His Asp Asp Phe Val Met Ile Asp 
        435                 440                 445             


Phe Lys Pro Ala Phe Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly 
    450                 455                 460                 


Thr Phe Tyr Arg Glu Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser 
465                 470                 475                 480 


Ile Asp Ile Gly Ala Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro 
                485                 490                 495     


Glu Lys Leu Ala Val His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe 
            500                 505                 510         


Val Glu Thr Leu Gln 
        515         


<210> 5334
<211> 495
<212> PRT
<213> Homo sapiens

<400> 5334
Met Trp Arg Gly Cys Ala Arg Ser Arg Lys Arg Lys Lys Val Asp Asn 
1               5                   10                  15      


Asp Tyr Asn Ala Leu Arg Glu Arg Leu Ser Thr Leu Pro Asp Lys Leu 
            20                  25                  30          


Ser Tyr Asn Ile Met Val Pro Phe Gly Pro Phe Ala Phe Met Pro Gly 
        35                  40                  45              


Lys Leu Val His Thr Asn Glu Val Thr Val Leu Leu Gly Asp Asn Trp 
    50                  55                  60                  


Phe Ala Lys Cys Ser Ala Lys Gln Ala Val Gly Leu Val Glu His Arg 
65                  70                  75                  80  


Lys Glu His Val Arg Lys Thr Ile Asp Asp Leu Lys Lys Val Met Lys 
                85                  90                  95      


Asn Phe Glu Ser Arg Val Glu Phe Thr Glu Asp Leu Gln Lys Met Ser 
            100                 105                 110         


Asp Ala Ala Gly Asp Ile Val Asp Ile Arg Glu Glu Ile Lys Cys Asp 
        115                 120                 125             


Phe Glu Phe Lys Ala Lys His Arg Ile Ala His Lys Pro His Ser Lys 
    130                 135                 140                 


Pro Lys Thr Ser Asp Ile Phe Glu Ala Asp Ile Ala Asn Asp Val Lys 
145                 150                 155                 160 


Ser Lys Asp Leu Leu Ala Asp Lys Glu Leu Trp Ala Arg Leu Glu Glu 
                165                 170                 175     


Leu Glu Arg Gln Glu Glu Leu Leu Gly Glu Leu Asp Ser Lys Pro Asp 
            180                 185                 190         


Thr Val Ile Ala Asn Gly Glu Asp Thr Thr Ser Ser Glu Glu Glu Lys 
        195                 200                 205             


Glu Asp Arg Asn Thr Asn Val Asn Ala Met His Gln Val Thr Asp Ser 
    210                 215                 220                 


His Thr Pro Cys His Lys Asp Val Ala Ser Ser Glu Pro Phe Ser Gly 
225                 230                 235                 240 


Gln Val Asn Ser Gln Leu Asn Cys Ser Val Asn Gly Ser Ser Ser Tyr 
                245                 250                 255     


His Ser Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asn 
            260                 265                 270         


Ile Asp Asp Asp Asp Gly Asp Asn Asp His Glu Ala Leu Gly Val Gly 
        275                 280                 285             


Asp Asn Ser Ile Pro Thr Ile Tyr Phe Ser His Thr Val Glu Pro Lys 
    290                 295                 300                 


Arg Val Arg Ile Asn Thr Gly Lys Asn Thr Thr Leu Lys Phe Ser Glu 
305                 310                 315                 320 


Lys Lys Glu Glu Ala Lys Arg Lys Arg Lys Asn Ser Thr Gly Ser Gly 
                325                 330                 335     


His Ser Ala Gln Glu Leu Pro Thr Ile Arg Thr Pro Ala Asp Ile Tyr 
            340                 345                 350         


Arg Ala Phe Val Asp Val Val Asn Gly Glu Tyr Val Pro Arg Lys Ser 
        355                 360                 365             


Ile Leu Lys Ser Arg Ser Arg Glu Asn Ser Val Cys Ser Asp Thr Ser 
    370                 375                 380                 


Glu Ser Ser Ala Ala Glu Phe Asp Asp Arg Arg Gly Val Leu Arg Ser 
385                 390                 395                 400 


Ile Ser Cys Glu Glu Ala Thr Cys Ser Asp Thr Ser Glu Ser Ile Leu 
                405                 410                 415     


Glu Glu Glu Pro Gln Glu Asn Gln Lys Lys Leu Leu Pro Leu Ser Val 
            420                 425                 430         


Thr Pro Glu Ala Phe Ser Gly Thr Val Ile Glu Lys Glu Phe Val Ser 
        435                 440                 445             


Pro Ser Leu Thr Pro Pro Pro Ala Ile Ala His Pro Ala Leu Pro Thr 
    450                 455                 460                 


Ile Pro Glu Arg Lys Glu Val Leu Leu Glu Ala Ser Glu Glu Thr Gly 
465                 470                 475                 480 


Lys Arg Val Ser Lys Phe Lys Ala Ala Arg Leu Gln Gln Lys Asp 
                485                 490                 495 


<210> 5335
<211> 485
<212> PRT
<213> Homo sapiens

<400> 5335
Met Cys Gln Val Gly Glu Asp Tyr Gly Glu Pro Ala Pro Glu Glu Pro 
1               5                   10                  15      


Pro Pro Ala Pro Arg Pro Ser Arg Glu Gln Lys Cys Val Lys Cys Lys 
            20                  25                  30          


Glu Ala Gln Pro Val Val Val Ile Arg Ala Gly Asp Ala Phe Cys Arg 
        35                  40                  45              


Asp Cys Phe Lys Ala Phe Tyr Val His Lys Phe Arg Ala Met Leu Gly 
    50                  55                  60                  


Lys Asn Arg Leu Ile Phe Pro Gly Glu Lys Val Leu Leu Ala Trp Ser 
65                  70                  75                  80  


Gly Gly Pro Ser Ser Ser Ser Met Val Trp Gln Val Leu Glu Gly Leu 
                85                  90                  95      


Ser Gln Asp Ser Ala Lys Arg Leu Arg Phe Val Ala Gly Val Ile Phe 
            100                 105                 110         


Val Asp Glu Gly Ala Ala Cys Gly Gln Ser Leu Glu Glu Arg Ser Lys 
        115                 120                 125             


Thr Leu Ala Glu Val Lys Pro Ile Leu Gln Ala Thr Gly Phe Pro Trp 
    130                 135                 140                 


His Val Val Ala Leu Glu Glu Val Phe Ser Leu Pro Pro Ser Val Leu 
145                 150                 155                 160 


Trp Cys Ser Ala Gln Glu Leu Val Gly Ser Glu Gly Ala Tyr Lys Ala 
                165                 170                 175     


Ala Val Asp Ser Phe Leu Gln Gln Gln His Val Leu Gly Ala Gly Gly 
            180                 185                 190         


Gly Pro Gly Pro Thr Gln Gly Glu Glu Gln Pro Pro Gln Pro Pro Leu 
        195                 200                 205             


Asp Pro Gln Asn Leu Ala Arg Pro Pro Ala Pro Ala Gln Thr Glu Ala 
    210                 215                 220                 


Leu Ser Gln Leu Phe Cys Ser Val Arg Thr Leu Thr Ala Lys Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Thr Leu Arg Thr His Leu Ile Leu His Met Ala Arg Ala 
                245                 250                 255     


His Gly Tyr Ser Lys Val Met Thr Gly Asp Ser Cys Thr Arg Leu Ala 
            260                 265                 270         


Ile Lys Leu Met Thr Asn Leu Ala Leu Gly Arg Gly Ala Phe Leu Ala 
        275                 280                 285             


Trp Asp Thr Gly Phe Ser Asp Glu Arg His Gly Asp Val Val Val Val 
    290                 295                 300                 


Arg Pro Met Arg Asp His Thr Leu Lys Glu Val Ala Phe Tyr Asn Arg 
305                 310                 315                 320 


Leu Phe Ser Val Pro Ser Val Phe Thr Pro Ala Val Asp Thr Lys Ala 
                325                 330                 335     


Pro Glu Lys Ala Ser Ile His Arg Leu Met Glu Ala Phe Ile Leu Arg 
            340                 345                 350         


Leu Gln Thr Gln Phe Pro Ser Thr Val Ser Thr Val Tyr Arg Thr Ser 
        355                 360                 365             


Glu Lys Leu Val Lys Gly Pro Arg Asp Gly Pro Ala Ala Gly Asp Ser 
    370                 375                 380                 


Gly Pro Arg Cys Leu Leu Cys Met Cys Ala Leu Asp Val Asp Ala Ala 
385                 390                 395                 400 


Asp Ser Ala Thr Ala Phe Gly Ala Gln Thr Ser Ser Arg Leu Ser Gln 
                405                 410                 415     


Met Gln Ser Pro Ile Pro Leu Thr Glu Thr Arg Thr Pro Pro Gly Pro 
            420                 425                 430         


Cys Cys Ser Pro Gly Val Gly Trp Ala Gln Arg Cys Gly Gln Gly Ala 
        435                 440                 445             


Cys Arg Arg Glu Asp Pro Gln Ala Cys Ile Glu Glu Gln Leu Cys Tyr 
    450                 455                 460                 


Ser Cys Arg Val Asn Met Lys Asp Leu Gly Leu Gly Leu Ala Gly Asp 
465                 470                 475                 480 


Pro Gly Leu Ser Asp 
                485 


<210> 5336
<211> 450
<212> PRT
<213> Homo sapiens

<400> 5336
Met Ser Leu Arg Leu Ser Ser Ala Ser Arg Arg Ser Cys Pro Arg Pro 
1               5                   10                  15      


Thr Thr Gly Ser Leu Arg Leu Tyr Gly Gly Gly Thr Ser Phe Gly Thr 
            20                  25                  30          


Gly Asn Ser Cys Gly Ile Ser Gly Ile Gly Ser Gly Phe Ser Ser Ala 
        35                  40                  45              


Phe Gly Gly Ser Ser Ser Gly Gly Asn Thr Gly Gly Gly Asn Pro Cys 
    50                  55                  60                  


Ala Gly Phe Thr Val Asn Glu Arg Gly Leu Leu Ser Gly Asn Glu Lys 
65                  70                  75                  80  


Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Ser 
                85                  90                  95      


Val His Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu Gln Lys Ile Lys 
            100                 105                 110         


Gly Trp Tyr Glu Lys Phe Gly Pro Gly Ser Cys Arg Gly Leu Asp His 
        115                 120                 125             


Asp Tyr Ser Arg Tyr Phe Pro Ile Ile Asp Asp Leu Lys Asn Gln Ile 
    130                 135                 140                 


Ile Ala Ser Thr Thr Ser Asn Ala Asn Ala Val Leu Gln Ile Asp Asn 
145                 150                 155                 160 


Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Leu 
                165                 170                 175     


Ala Leu His Gln Ser Val Glu Ala Asp Val Asn Gly Leu Arg Arg Val 
            180                 185                 190         


Leu Asp Glu Ile Thr Leu Cys Arg Thr Asp Leu Glu Ile Gln Tyr Glu 
        195                 200                 205             


Thr Leu Ser Glu Glu Met Thr Tyr Leu Lys Lys Asn His Lys Glu Glu 
    210                 215                 220                 


Met Gln Val Leu Gln Cys Ala Ala Gly Gly Asn Val Asn Val Glu Met 
225                 230                 235                 240 


Asn Ala Ala Pro Gly Val Asp Leu Thr Val Leu Leu Asn Asn Met Arg 
                245                 250                 255     


Ala Glu Tyr Glu Ala Leu Ala Glu Gln Asn Arg Arg Asp Ala Glu Ala 
            260                 265                 270         


Trp Phe Asn Glu Lys Ser Ala Ser Leu Gln Gln Gln Ile Ser Glu Asp 
        275                 280                 285             


Val Gly Ala Thr Thr Ser Ala Arg Asn Glu Leu Thr Glu Met Lys Arg 
    290                 295                 300                 


Thr Leu Gln Thr Leu Glu Ile Glu Leu Gln Ser Leu Leu Ala Thr Lys 
305                 310                 315                 320 


His Ser Leu Glu Cys Ser Leu Thr Glu Thr Glu Ser Asn Tyr Cys Ala 
                325                 330                 335     


Gln Leu Ala Gln Ile Gln Ala Gln Ile Gly Ala Leu Glu Glu Gln Leu 
            340                 345                 350         


His Gln Val Arg Thr Glu Thr Glu Gly Gln Lys Leu Glu Tyr Glu Gln 
        355                 360                 365             


Leu Leu Asp Ile Lys Leu His Leu Glu Lys Glu Ile Glu Thr Tyr Cys 
    370                 375                 380                 


Leu Leu Ile Gly Gly Asp Asp Gly Ala Cys Lys Ser Gly Gly Tyr Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Gly Ser Gly Asn Val Gly Ser Gln Val Lys Asp Pro 
                405                 410                 415     


Ala Lys Ala Ile Val Val Lys Lys Val Leu Glu Glu Val Asp Gln Arg 
            420                 425                 430         


Ser Lys Ile Leu Thr Thr Arg Leu His Ser Leu Glu Glu Lys Ser Gln 
        435                 440                 445             


Ser Asn 
    450 


<210> 5337
<211> 892
<212> PRT
<213> Homo sapiens

<400> 5337
Met Asp Gln Pro Glu Ala Pro Cys Ser Ser Thr Gly Pro Arg Leu Ala 
1               5                   10                  15      


Val Ala Arg Glu Leu Leu Leu Ala Ala Leu Glu Glu Leu Ser Gln Glu 
            20                  25                  30          


Gln Leu Lys Arg Phe Arg His Lys Leu Arg Asp Val Gly Pro Asp Gly 
        35                  40                  45              


Arg Ser Ile Pro Trp Gly Arg Leu Glu Arg Ala Asp Ala Val Asp Leu 
    50                  55                  60                  


Ala Glu Gln Leu Ala Gln Phe Tyr Gly Pro Glu Pro Ala Leu Glu Val 
65                  70                  75                  80  


Ala Arg Lys Thr Leu Lys Arg Ala Asp Ala Arg Asp Val Ala Ala Gln 
                85                  90                  95      


Leu Gln Glu Arg Arg Leu Gln Arg Leu Gly Leu Gly Ser Gly Thr Leu 
            100                 105                 110         


Leu Ser Val Ser Glu Tyr Lys Lys Lys Tyr Arg Glu His Val Leu Gln 
        115                 120                 125             


Leu His Ala Arg Val Lys Glu Arg Asn Ala Arg Ser Val Lys Ile Thr 
    130                 135                 140                 


Lys Arg Phe Thr Lys Leu Leu Ile Ala Pro Glu Ser Ala Ala Pro Glu 
145                 150                 155                 160 


Glu Ala Met Gly Pro Ala Glu Glu Pro Glu Pro Gly Arg Ala Arg Arg 
                165                 170                 175     


Ser Asp Thr His Thr Phe Asn Arg Leu Phe Arg Arg Asp Glu Glu Gly 
            180                 185                 190         


Arg Arg Pro Leu Thr Val Val Leu Gln Gly Pro Ala Gly Ile Gly Lys 
        195                 200                 205             


Thr Met Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu 
    210                 215                 220                 


Tyr Gln Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu 
225                 230                 235                 240 


Leu Glu Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln 
                245                 250                 255     


Cys Pro Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln 
            260                 265                 270         


Arg Leu Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly 
        275                 280                 285             


Gly Pro Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly 
    290                 295                 300                 


Ala Arg Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala 
305                 310                 315                 320 


Leu Leu Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly 
                325                 330                 335     


Arg Leu Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys 
            340                 345                 350         


Asp Lys Lys Lys Tyr Phe Tyr Lys Tyr Phe Arg Asp Glu Arg Arg Ala 
        355                 360                 365             


Glu Arg Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu 
    370                 375                 380                 


Cys Phe Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln 
385                 390                 395                 400 


Gln Leu Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr 
                405                 410                 415     


Ser Val Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val 
            420                 425                 430         


Ala Asp Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu 
        435                 440                 445             


Ala Arg Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu 
    450                 455                 460                 


Leu Glu Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu 
465                 470                 475                 480 


Ser Lys Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln 
                485                 490                 495     


Phe Ile Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu 
            500                 505                 510         


Leu Glu Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr 
        515                 520                 525             


Leu Leu Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr 
    530                 535                 540                 


Arg Phe Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu 
545                 550                 555                 560 


Arg His Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu 
                565                 570                 575     


Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu 
            580                 585                 590         


Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu 
        595                 600                 605             


Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys 
    610                 615                 620                 


Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg 
625                 630                 635                 640 


Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val 
                645                 650                 655     


Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu 
            660                 665                 670         


Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys 
        675                 680                 685             


Ser Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly Gly Ser Ser Ser 
    690                 695                 700                 


Gln Gly Thr Thr Lys Gln Leu Pro Ala Ser Leu Leu His Pro Leu Phe 
705                 710                 715                 720 


Gln Ala Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu Thr Leu Ser 
                725                 730                 735     


His Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser Glu Ala Leu 
            740                 745                 750         


Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His Asn Arg Leu 
        755                 760                 765             


Ser Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala Trp Pro Gln 
    770                 775                 780                 


Cys Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro Gln Arg Gly 
785                 790                 795                 800 


Leu Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala Leu Thr Thr 
                805                 810                 815     


Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val Thr Tyr Leu 
            820                 825                 830         


Cys Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr Leu Ser Leu 
        835                 840                 845             


Ala Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu Gln Ala Val 
    850                 855                 860                 


Lys Arg Ala Lys Pro Asp Leu Val Ile Thr His Pro Ala Leu Asp Gly 
865                 870                 875                 880 


His Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe 
                885                 890         


<210> 5338
<211> 348
<212> PRT
<213> Homo sapiens

<400> 5338
Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
1               5                   10                  15      


Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly Leu Tyr 
    50                  55                  60                  


Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
            100                 105                 110         


Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
        115                 120                 125             


Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
    130                 135                 140                 


Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu Pro Leu 
145                 150                 155                 160 


Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu Leu Arg 
                165                 170                 175     


Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met Lys Ile 
            180                 185                 190         


Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr Glu Asp 
        195                 200                 205             


Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly Thr Lys 
    210                 215                 220                 


Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile Pro Ala 
225                 230                 235                 240 


Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe Arg Arg 
                245                 250                 255     


Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys Glu Ala 
            260                 265                 270         


Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg Val Ile 
        275                 280                 285             


Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys Arg Leu 
    290                 295                 300                 


Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg Gly Asp 
305                 310                 315                 320 


Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr Pro Gln 
                325                 330                 335     


Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
            340                 345             


<210> 5339
<211> 632
<212> PRT
<213> Homo sapiens

<400> 5339
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                165                 170                 175     


Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
            180                 185                 190         


Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
        195                 200                 205             


Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
    210                 215                 220                 


Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
225                 230                 235                 240 


Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                245                 250                 255     


Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
            260                 265                 270         


Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
        275                 280                 285             


Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys Gly 
    290                 295                 300                 


Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys Arg 
305                 310                 315                 320 


Val Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys Ile 
                325                 330                 335     


Pro Thr Leu Ile Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu Ala 
            340                 345                 350         


Asp Phe Val Ser Gln Thr Ser Pro Met Ile Pro Ser Ile Val Val His 
        355                 360                 365             


Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Thr Gly Leu Tyr 
    370                 375                 380                 


Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys Phe 
385                 390                 395                 400 


Leu Arg Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile His 
                405                 410                 415     


Ala Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu Pro 
            420                 425                 430         


Leu Leu Thr Phe Arg Leu Asn Arg Ala Phe Met Glu Ala Ala Glu Ile 
        435                 440                 445             


Thr Asp Glu Asp Asn Ser Ile Ala Ala Met Tyr Gln Ala Val Gly Glu 
    450                 455                 460                 


Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His Leu 
465                 470                 475                 480 


Gln Arg Val Ala Gln Ser Pro His Thr Lys Met Asp Val Ala Asn Leu 
                485                 490                 495     


Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Ala Val Pro Asn Pro 
            500                 505                 510         


Asp Pro Val Thr Met Leu Gln Asp Ile Lys Arg Gln Pro Lys Val Val 
        515                 520                 525             


Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Ser Gln Phe Met Met 
    530                 535                 540                 


Val Glu Gln Glu Asn Ile Asp Pro Leu His Val Ile Glu Asn Ser Asn 
545                 550                 555                 560 


Ala Phe Ser Thr Pro Gln Thr Pro Asp Ile Lys Val Ser Leu Leu Gly 
                565                 570                 575     


Pro Val Thr Thr Pro Glu His Gln Leu Leu Lys Thr Pro Ser Ser Ser 
            580                 585                 590         


Ser Leu Ser Gln Arg Val Arg Ser Thr Leu Thr Lys Asn Thr Pro Arg 
        595                 600                 605             


Phe Gly Ser Lys Ser Lys Ser Ala Thr Asn Leu Gly Arg Gln Gly Asn 
    610                 615                 620                 


Phe Phe Ala Ser Pro Met Leu Lys 
625                 630         


<210> 5340
<211> 4024
<212> PRT
<213> Homo sapiens

<400> 5340
Met Ser Ser Glu Gln Asp Lys Ser Ala Ser Lys Glu Lys Ser Lys Lys 
1               5                   10                  15      


Pro Val Arg Phe Leu Pro Gln Leu Ser Met Glu Lys Leu Ala Ser Lys 
            20                  25                  30          


Glu Lys Phe Lys Ala Pro Ala Arg Ala Leu Pro Gln Leu Ser Met Val 
        35                  40                  45              


Ser Thr Lys Pro His Trp Gln Gln Ala Ala Pro Ser Phe His Leu Ser 
    50                  55                  60                  


Val Lys Gln Asp Asp Glu Ser Pro Glu Pro Phe Ser Val Lys Asn Glu 
65                  70                  75                  80  


Gln Ser His Ala Glu Tyr Met Glu Arg Phe Gly Lys Lys Gly Lys Leu 
                85                  90                  95      


Pro His Gln Val Asp Asp Ser Tyr Val Gly Pro Ser Thr Ser Lys Ser 
            100                 105                 110         


Lys Gly Lys Ser Pro His Lys Glu Arg Glu Asn Phe Arg Ser Thr Leu 
        115                 120                 125             


Val Asn Val Ile Met Gln Gln Asp Ala Asp Leu Asp Ser Ala Val Pro 
    130                 135                 140                 


Asp Gly Ser Thr Ile Pro Lys Pro Thr Ala Ser Ala Ile Glu Lys Asp 
145                 150                 155                 160 


Ile Leu Arg Tyr Tyr Tyr Tyr Ile His His Gly Ile Asp Thr Asp His 
                165                 170                 175     


Val Ala Pro Met Glu Asp Ser Trp Leu Glu His Val Leu Asp Leu Val 
            180                 185                 190         


Pro Gln His Leu Lys Val Phe Thr Asp Ser Ile Val Thr Leu Ser Asp 
        195                 200                 205             


Glu Met Arg Glu Asp Tyr Leu Leu Ser Val Arg Lys Ser Ile Val Asp 
    210                 215                 220                 


Phe Val Leu Lys Asp Pro Arg Glu Lys Gly Asp Asp Lys Lys Thr Asp 
225                 230                 235                 240 


Glu Leu Pro Ala His Arg Ala Glu Met Glu Ile Leu Pro Lys Pro Trp 
                245                 250                 255     


Arg Lys Ser Phe Leu Ala Ala Ser Ser Tyr Ile Arg Asp His Leu Asn 
            260                 265                 270         


Ala Met Asn Pro Thr Met Leu Ala Val Leu Asp Leu Trp His Thr Asn 
        275                 280                 285             


Phe Lys Lys Leu Arg Leu Val Asp Ile Lys Glu Phe His Asn Cys Gln 
    290                 295                 300                 


Asp Ala Leu Glu Leu Ser Ser Phe Gln Asn Ile Ile Met Arg His Met 
305                 310                 315                 320 


Asp Ser Ala Lys Glu Thr Leu Leu Lys Met Trp Phe Pro Glu Val Gln 
                325                 330                 335     


Asn Ile Tyr Tyr Gln Gly Asn Lys Lys Lys Gln Leu Pro Thr Gly Asp 
            340                 345                 350         


Ser Ser Ala Lys Leu Glu Ser Phe Phe Asn Cys Ala Ala Ala Leu Met 
        355                 360                 365             


Thr Leu Gln Leu Gln Asp Leu Thr Leu Val Ser Met Gln Asp Phe Thr 
    370                 375                 380                 


Asp Leu Ile Ala Gln Pro Pro Asp Ser Val Arg Ala Phe Glu His Pro 
385                 390                 395                 400 


Gly Phe Ile Met Arg Leu Ile Leu Asp Asn Asp Thr Ile Lys Phe Glu 
                405                 410                 415     


Pro Glu Leu Ser Asp Tyr Ile Asp Ile Phe Leu Asn Val Tyr Asp Val 
            420                 425                 430         


Met Ile Lys Ala Val Ser Phe Val Pro Arg Val Glu Thr Lys Leu Tyr 
        435                 440                 445             


Ser Lys Trp Glu Ser Lys Ser Lys Pro Thr Thr Leu Lys Pro Ile Ile 
    450                 455                 460                 


Leu Asn Glu Ile Val Asp Ala His Lys Glu Lys Ile Lys Glu Val Ile 
465                 470                 475                 480 


Met Lys Glu Ser Val Ala Pro Thr Glu His Leu Arg Leu Tyr Asp Lys 
                485                 490                 495     


Tyr Asp Phe Leu Ile Thr Arg Lys Ala Glu Arg Asp Val Asp Asn Phe 
            500                 505                 510         


Leu Ala Glu Asn His Ser Tyr Glu Lys Ile Ile Asp Glu Ile Cys Lys 
        515                 520                 525             


Tyr Gln Lys Leu Ile Glu Glu Ile Gln Tyr Thr Ser Ile Lys Thr Ile 
    530                 535                 540                 


Arg Leu Gly Met Phe Glu Met His Cys Glu Glu Leu Ile Arg Ala Leu 
545                 550                 555                 560 


Val Lys Arg Ala Asp Ile Ile Cys Gly Lys Leu Leu Ala Lys Met Phe 
                565                 570                 575     


Arg Asp His Gln Glu Val Asn Thr Arg Leu Cys Asp Glu Phe Glu Arg 
            580                 585                 590         


Ile Ala Glu Lys Ala Leu Ser Thr Pro Pro Asn Thr Ala Glu Leu Met 
        595                 600                 605             


Glu Met Lys Ala Tyr Ile Gln Lys Val Glu Val Thr Asp Met Ile Glu 
    610                 615                 620                 


Leu Glu Gln Arg Leu Val Asp Ser Lys Asn Cys Leu Ala Phe Leu Ile 
625                 630                 635                 640 


Glu Tyr Val Asn Phe Ser Pro Ala Asp Met Arg Leu Asn Asn Ser Val 
                645                 650                 655     


Phe Gln Trp Tyr Gly Arg Met Gly Glu Ile Phe Glu Glu His Arg Lys 
            660                 665                 670         


Ile Ile Lys Glu Lys Ile Glu Gln Tyr Gln Glu Gly Leu Lys Leu Arg 
        675                 680                 685             


Cys Glu Arg Phe Val Glu Glu Leu Glu Ser Tyr Ala Lys Gln Ser Glu 
    690                 695                 700                 


Glu Phe Tyr Ser Phe Gly Asp Leu Gln Asp Val Gln Arg Tyr Leu Lys 
705                 710                 715                 720 


Lys Ala Gln Ile Leu Asn Gly Lys Leu Asp Leu Ala Ala Asp Lys Ile 
                725                 730                 735     


Glu Gln Phe Asn Ala Glu Glu Glu Ala Phe Gly Trp Leu Pro Ser Val 
            740                 745                 750         


Tyr Pro Gln Arg Lys Lys Ile Gln Asp Gly Leu Asn Pro Tyr Leu Arg 
        755                 760                 765             


Leu Tyr Glu Thr Ala Val Glu Phe Ser Ser Asn Tyr Arg Ala Trp Thr 
    770                 775                 780                 


Glu Gly Pro Tyr His Lys Val Asn Pro Asp Gln Val Glu Ala Asp Ile 
785                 790                 795                 800 


Gly Asn Tyr Trp Arg Gly Leu Tyr Lys Leu Glu Lys Thr Phe His Asp 
                805                 810                 815     


Ser Pro Tyr Ala Leu Ala Met Thr Lys Lys Val Arg Ser Lys Val Glu 
            820                 825                 830         


Asp Phe Lys Gln His Ile Pro Leu Ile Gln Val Ile Cys Asn Pro Gly 
        835                 840                 845             


Leu Arg Pro Arg His Trp Glu Ala Met Ser Ala Ile Val Gly Tyr Pro 
    850                 855                 860                 


Leu Gln Pro Ser Asp Asp Ser Thr Val Ser Ser Phe Leu Asp Met Asn 
865                 870                 875                 880 


Leu Glu Pro Tyr Ile Asp Arg Phe Glu Gly Ile Ser Glu Ala Ala Ser 
                885                 890                 895     


Lys Glu Tyr Ser Leu Glu Lys Ala Met Glu Lys Met Ile Thr Glu Trp 
            900                 905                 910         


Asp Ala Val Glu Phe Val Ile His Ser Tyr Arg Glu Thr Gly Thr Phe 
        915                 920                 925             


Ile Leu Ala Ser Val Asp Glu Ile Gln Met Leu Leu Asp Asp His Ile 
    930                 935                 940                 


Ile Lys Thr Gln Thr Met Arg Gly Ser Pro Phe Ile Lys Pro Tyr Glu 
945                 950                 955                 960 


Lys Gln Met Arg Glu Trp Glu Gly Lys Leu Leu Leu Leu Gln Glu Ile 
                965                 970                 975     


Leu Asp Glu Trp Leu Lys Val Gln Ala Thr Trp Leu Tyr Leu Glu Pro 
            980                 985                 990         


Ile Phe Ser Ser Pro Asp Ile Met  Ser Gln Met Pro Glu  Glu Gly Arg 
        995                 1000                 1005             


Arg Phe  Thr Ala Val Asp Lys  Thr Trp Arg Asp Ile  Met Arg Ser 
    1010                 1015                 1020             


Val Met  Gln Asp Lys His Val  Leu Thr Val Val Thr  Ile Asp Arg 
    1025                 1030                 1035             


Met Leu  Glu Arg Leu Lys Lys  Ser Asn Glu Leu Leu  Glu Leu Ile 
    1040                 1045                 1050             


Leu Lys  Gly Leu Asn Glu Tyr  Leu Glu Lys Lys Arg  Leu Phe Phe 
    1055                 1060                 1065             


Pro Arg  Phe Phe Phe Leu Ser  Asn Asp Glu Leu Leu  Glu Ile Leu 
    1070                 1075                 1080             


Ser Glu  Thr Lys Asp Pro Thr  Arg Val Gln Pro His  Leu Lys Lys 
    1085                 1090                 1095             


Cys Phe  Glu Gly Ile Ala Lys  Val Glu Phe Thr Glu  Thr Leu Asp 
    1100                 1105                 1110             


Ile Thr  His Met Lys Ser Ser  Glu Gly Glu Val Val  Glu Leu Ile 
    1115                 1120                 1125             


Glu Ile  Ile Ser Thr Ala Lys  Ala Arg Gly Gln Val  Glu Lys Trp 
    1130                 1135                 1140             


Leu Val  Glu Leu Glu Arg Val  Met Ile Asn Ser Ile  His Lys Val 
    1145                 1150                 1155             


Thr Gly  Asp Ala Thr Phe Ala  Tyr Thr Lys Tyr Glu  Arg Ile Asn 
    1160                 1165                 1170             


Trp Val  Arg Asp Trp Pro Gly  Gln Thr Val Leu Cys  Val Ser Gln 
    1175                 1180                 1185             


Ile Phe  Trp Thr Lys Glu Val  Gln Thr Ala Ile Pro  Met Gly Ile 
    1190                 1195                 1200             


Lys Ala  Leu Glu Gln Tyr Leu  Lys Thr Cys Asn Arg  Gln Ile Asp 
    1205                 1210                 1215             


Asp Ile  Val Thr Leu Val Arg  Gly Lys Leu Ser Met  Gln Asn Arg 
    1220                 1225                 1230             


Val Thr  Leu Gly Ala Leu Val  Val Leu Asp Val His  Ala Arg Asp 
    1235                 1240                 1245             


Val Leu  Ser Ser Leu Val Lys  Lys Asn Ile Ser Asp  Asp Ser Asp 
    1250                 1255                 1260             


Phe Glu  Trp Leu Ser Gln Leu  Arg Tyr Tyr Trp Gln  Glu Asn His 
    1265                 1270                 1275             


Leu Glu  Thr Lys Met Ile Asn  Ala Gly Leu Arg Tyr  Gly Tyr Glu 
    1280                 1285                 1290             


Tyr Leu  Gly Asn Ser Pro Arg  Leu Val Ile Thr Pro  Leu Thr Asp 
    1295                 1300                 1305             


Arg Cys  Tyr Arg Thr Leu Phe  Gly Ala Leu His Leu  His Leu Gly 
    1310                 1315                 1320             


Gly Ala  Pro Glu Gly Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Thr 
    1325                 1330                 1335             


Lys Asp  Leu Ala Lys Ala Val  Ala Lys Gln Cys Val  Val Phe Asn 
    1340                 1345                 1350             


Cys Ser  Asp Gly Leu Asp Tyr  Leu Ala Leu Gly Lys  Phe Phe Lys 
    1355                 1360                 1365             


Gly Leu  Leu Ser Cys Gly Ala  Trp Ala Cys Phe Asp  Glu Phe Asn 
    1370                 1375                 1380             


Arg Ile  Asp Leu Glu Val Leu  Ser Val Val Ala Gln  Gln Ile Leu 
    1385                 1390                 1395             


Thr Ile  Gln Arg Gly Ile Asn  Ala Gly Ala Asp Ile  Leu Met Phe 
    1400                 1405                 1410             


Glu Gly  Thr Glu Leu Lys Leu  Asp Pro Thr Cys Ala  Val Phe Ile 
    1415                 1420                 1425             


Thr Met  Asn Pro Gly Tyr Ala  Gly Arg Ser Glu Leu  Pro Asp Asn 
    1430                 1435                 1440             


Leu Lys  Ala Leu Phe Arg Thr  Val Ala Met Met Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Met  Ile Ala Glu Ile Val  Leu Tyr Ser Cys Gly  Phe Val Thr 
    1460                 1465                 1470             


Ala Arg  Pro Leu Ser Val Lys  Ile Val Ala Thr Tyr  Arg Leu Cys 
    1475                 1480                 1485             


Ser Glu  Gln Leu Ser Ser Gln  His His Tyr Asp Tyr  Gly Met Arg 
    1490                 1495                 1500             


Ala Val  Lys Ser Val Leu Thr  Ala Ala Gly Asn Leu  Lys Leu Lys 
    1505                 1510                 1515             


Tyr Pro  Asn Glu Asn Glu Glu  Ile Leu Leu Leu Arg  Ser Ile Ile 
    1520                 1525                 1530             


Asp Val  Asn Leu Pro Lys Phe  Leu Ser His Asp Leu  Pro Leu Phe 
    1535                 1540                 1545             


Glu Gly  Ile Thr Ser Asp Leu  Phe Pro Gly Val Lys  Leu Pro Lys 
    1550                 1555                 1560             


Pro Asp  Tyr Asn Asp Leu Leu  Ala Ala Ile Lys Asp  Asn Cys Ala 
    1565                 1570                 1575             


Ser Met  Asn Leu Gln Met Thr  Ala Phe Phe Ser Glu  Lys Ile Leu 
    1580                 1585                 1590             


Gln Val  Tyr Glu Met Met Ile  Val Arg His Gly Phe  Met Ile Val 
    1595                 1600                 1605             


Gly Glu  Pro Phe Gly Gly Lys  Thr Ser Ala Tyr Arg  Val Leu Ala 
    1610                 1615                 1620             


Gly Ala  Leu Asn Asp Ile Cys  Glu Lys Gly Leu Met  Glu Glu Asn 
    1625                 1630                 1635             


Lys Val  Gln Ile Thr Val Leu  Asn Pro Lys Ser Val  Thr Met Gly 
    1640                 1645                 1650             


Gln Leu  Tyr Gly Gln Phe Asp  Ser Val Ser His Glu  Trp Ser Asp 
    1655                 1660                 1665             


Gly Val  Leu Ala Val Ser Phe  Arg Ala Phe Ala Ser  Ser Val Thr 
    1670                 1675                 1680             


Pro Asp  Arg Lys Trp Leu Ile  Phe Asp Gly Pro Val  Asp Ala Val 
    1685                 1690                 1695             


Trp Ile  Glu Asn Met Asn Thr  Val Leu Asp Asp Asn  Lys Lys Leu 
    1700                 1705                 1710             


Cys Leu  Met Ser Gly Glu Ile  Ile Gln Met Ser Pro  Gln Met Asn 
    1715                 1720                 1725             


Leu Ile  Phe Glu Pro Met Asp  Leu Glu Val Ala Ser  Pro Ala Thr 
    1730                 1735                 1740             


Val Ser  Arg Cys Gly Met Ile  Tyr Met Glu Pro His  Met Leu Gly 
    1745                 1750                 1755             


Trp Arg  Pro Leu Met Leu Ser  Trp Val Asn Leu Leu  Pro Ala Ser 
    1760                 1765                 1770             


Val Ser  Val Ile Gln Lys Glu  Phe Ile Met Gly Leu  Phe Asp Arg 
    1775                 1780                 1785             


Met Val  Pro Val Ser Val Glu  Phe Ile Arg Lys His  Thr Lys Glu 
    1790                 1795                 1800             


Leu Ser  Pro Thr Ser Asp Thr  Asn Leu Val Arg Ser  Leu Met Asn 
    1805                 1810                 1815             


Leu Ile  Asp Cys Phe Met Asp  Asp Phe Ala Asp Glu  Val Lys Leu 
    1820                 1825                 1830             


Lys Glu  Arg Asn Asp Arg Glu  Thr Tyr Ser Leu Leu  Glu Gly Ile 
    1835                 1840                 1845             


Phe Leu  Phe Ser Leu Ile Trp  Ser Val Gly Ala Ser  Cys Thr Asp 
    1850                 1855                 1860             


Asp Asp  Arg Leu Lys Phe Asn  Lys Ile Leu Arg Glu  Leu Met Glu 
    1865                 1870                 1875             


Ser Pro  Ile Ser Asp Arg Thr  Arg Asn Thr Phe Lys  Leu Gln Ser 
    1880                 1885                 1890             


Gly Thr  Glu Gln Thr Ser Ser  Lys Ala Leu Thr Val  Pro Phe Pro 
    1895                 1900                 1905             


Glu Lys  Gly Thr Ile Tyr Asp  Tyr Gln Phe Val Thr  Glu Gly Ile 
    1910                 1915                 1920             


Gly Lys  Trp Glu Pro Trp Ile  Lys Lys Leu Lys Glu  Ala Pro Pro 
    1925                 1930                 1935             


Ile Pro  Lys Asp Val Met Phe  Asn Glu Ile Ile Val  Pro Thr Leu 
    1940                 1945                 1950             


Asp Thr  Ile Arg Tyr Ser Ala  Leu Met Glu Leu Leu  Thr Thr His 
    1955                 1960                 1965             


Gln Lys  Pro Ser Ile Phe Val  Gly Pro Thr Gly Thr  Gly Lys Ser 
    1970                 1975                 1980             


Val Tyr  Ile Thr Asn Phe Leu  Leu Asn Gln Leu Asn  Lys Glu Ile 
    1985                 1990                 1995             


Tyr Lys  Pro Leu Leu Ile Asn  Phe Ser Ala Gln Thr  Thr Ala Ala 
    2000                 2005                 2010             


Gln Thr  Gln Asn Ile Val Met  Ser Lys Leu Asp Lys  Arg Arg Lys 
    2015                 2020                 2025             


Gly Val  Phe Gly Pro Pro Leu  Gly Lys Arg Met Val  Val Phe Val 
    2030                 2035                 2040             


Asp Asp  Val Asn Met Pro Ala  Arg Glu Val Tyr Gly  Ala Gln Pro 
    2045                 2050                 2055             


Pro Ile  Glu Leu Leu Arg Gln  Trp Leu Asp His Trp  Asn Trp Tyr 
    2060                 2065                 2070             


Asp Leu  Lys Asp Cys Ser Met  Ile Lys Leu Val Asp  Ile Gln Ile 
    2075                 2080                 2085             


Met Cys  Ala Met Gly Pro Pro  Gly Gly Gly Arg Asn  Pro Val Thr 
    2090                 2095                 2100             


Pro Arg  Tyr Met Arg His Phe  Asn Ile Ile Thr Ile  Asn Glu Phe 
    2105                 2110                 2115             


Ser Asp  Lys Ser Met Tyr Thr  Ile Phe Ser Arg Ile  Leu Thr Trp 
    2120                 2125                 2130             


His Leu  Glu Ile Cys Tyr Lys  Phe Pro Asp Glu Phe  Leu Asp Leu 
    2135                 2140                 2145             


Thr Thr  Gln Ile Val Asn Gly  Thr Met Thr Leu Tyr  Lys Glu Ala 
    2150                 2155                 2160             


Met Lys  Asn Leu Leu Pro Thr  Pro Ala Lys Ser His  Tyr Leu Phe 
    2165                 2170                 2175             


Asn Leu  Arg Asp Phe Ser Arg  Val Ile Gln Gly Val  Cys Leu Ser 
    2180                 2185                 2190             


Arg Pro  Glu Thr Thr Glu Thr  Thr Glu Val Ile Lys  Arg Leu Trp 
    2195                 2200                 2205             


Val His  Glu Val Leu Arg Val  Tyr Tyr Asp Arg Leu  Leu Asp Asn 
    2210                 2215                 2220             


Thr Asp  Arg Ser Trp Leu Ile  Asn Tyr Ile Gln Glu  Ile Leu Arg 
    2225                 2230                 2235             


Asn Tyr  Met Tyr Glu Asp Phe  His Glu Leu Phe Gln  Arg Leu Asp 
    2240                 2245                 2250             


Phe Asp  Asn Asp Gly Met Val  Glu Ala Asp Asp Leu  Arg Ser Leu 
    2255                 2260                 2265             


Met Phe  Cys Asp Phe His Asp  Pro Lys Arg Glu Asp  Thr Asn Tyr 
    2270                 2275                 2280             


Arg Glu  Ile Ala Asp Val Asp  Asn Leu Arg Met Ile  Val Glu Ile 
    2285                 2290                 2295             


His Leu  Glu Glu Tyr Asn Asn  Ile Ser Lys Lys Pro  Met Asn Leu 
    2300                 2305                 2310             


Val Leu  Phe Arg Phe Ala Ile  Glu His Ile Ser Arg  Ile Ser Arg 
    2315                 2320                 2325             


Ile Leu  Lys Gln Pro Arg Ser  His Ala Leu Leu Val  Gly Val Gly 
    2330                 2335                 2340             


Gly Ser  Gly Arg Gln Ser Val  Thr Arg Leu Ala Ala  His Met Ala 
    2345                 2350                 2355             


Asp Tyr  Ser Val Phe Gln Val  Glu Ile Ser Lys Gly  Tyr Asp Thr 
    2360                 2365                 2370             


Thr Glu  Trp His Glu Asp Leu  Lys Val Ile Leu Arg  Lys Cys Ala 
    2375                 2380                 2385             


Glu Gly  Glu Met Gln Gly Val  Phe Leu Phe Thr Asp  Thr Gln Ile 
    2390                 2395                 2400             


Lys Glu  Glu Ser Phe Leu Glu  Asp Val Ser Asn Leu  Leu Asn Ala 
    2405                 2410                 2415             


Gly Glu  Ile Pro Asn Leu Phe  Ala Leu Asp Glu Lys  Gln Glu Ile 
    2420                 2425                 2430             


Cys Asp  Lys Met Arg Gln Leu  Asp Arg Gln Arg Asp  Lys Thr Lys 
    2435                 2440                 2445             


Gln Thr  Asp Gly Ser Pro Ile  Ala Leu Phe Asn Met  Phe Ile Asp 
    2450                 2455                 2460             


His Cys  Arg Ser Gln Leu His  Val Val Leu Ala Met  Ser Pro Ile 
    2465                 2470                 2475             


Gly Asp  Ala Phe Arg Asn Arg  Leu Arg Lys Phe Pro  Ala Leu Val 
    2480                 2485                 2490             


Asn Cys  Cys Thr Ile Asp Trp  Phe Gln Ser Trp Pro  Glu Asp Ala 
    2495                 2500                 2505             


Leu Gln  Ala Val Ala Ser Arg  Phe Leu Glu Glu Ile  Glu Met Ser 
    2510                 2515                 2520             


Glu Glu  Ile Arg Asp Gly Cys  Ile Asp Met Cys Lys  Ser Phe His 
    2525                 2530                 2535             


Thr Ser  Thr Ile Asp Leu Ser  Lys Ser Phe Phe Val  Glu Leu Gln 
    2540                 2545                 2550             


Arg Tyr  Asn Tyr Val Thr Pro  Thr Ser Tyr Leu Glu  Leu Ile Ser 
    2555                 2560                 2565             


Thr Phe  Lys Leu Leu Leu Glu  Lys Lys Arg Ser Glu  Val Met Lys 
    2570                 2575                 2580             


Met Lys  Lys Arg Tyr Glu Val  Gly Leu Glu Lys Leu  Asp Ser Ala 
    2585                 2590                 2595             


Ser Ser  Gln Val Ala Thr Met  Gln Met Glu Leu Glu  Ala Leu His 
    2600                 2605                 2610             


Pro Gln  Leu Lys Val Ala Ser  Lys Glu Val Asp Glu  Met Met Ile 
    2615                 2620                 2625             


Met Ile  Glu Lys Glu Ser Val  Glu Val Ala Lys Thr  Glu Lys Ile 
    2630                 2635                 2640             


Val Lys  Ala Asp Glu Thr Ile  Ala Asn Glu Gln Ala  Met Ala Ser 
    2645                 2650                 2655             


Lys Ala  Ile Lys Asp Glu Cys  Asp Ala Asp Leu Ala  Gly Ala Leu 
    2660                 2665                 2670             


Pro Ile  Leu Glu Ser Ala Leu  Ala Ala Leu Asp Thr  Leu Thr Ala 
    2675                 2680                 2685             


Gln Asp  Ile Thr Val Val Lys  Ser Met Lys Ser Pro  Pro Ala Gly 
    2690                 2695                 2700             


Val Lys  Leu Val Met Glu Ala  Ile Cys Ile Leu Lys  Gly Ile Lys 
    2705                 2710                 2715             


Ala Asp  Lys Ile Pro Asp Pro  Thr Gly Ser Gly Lys  Lys Ile Glu 
    2720                 2725                 2730             


Asp Phe  Trp Gly Pro Ala Lys  Arg Leu Leu Gly Asp  Met Arg Phe 
    2735                 2740                 2745             


Leu Gln  Ser Leu His Glu Tyr  Asp Lys Asp Asn Ile  Pro Pro Ala 
    2750                 2755                 2760             


Tyr Met  Asn Ile Ile Arg Lys  Asn Tyr Ile Pro Asn  Pro Asp Phe 
    2765                 2770                 2775             


Val Pro  Glu Lys Ile Arg Asn  Ala Ser Thr Ala Ala  Glu Gly Leu 
    2780                 2785                 2790             


Cys Lys  Trp Val Ile Ala Met  Asp Ser Tyr Asp Lys  Val Ala Lys 
    2795                 2800                 2805             


Ile Val  Ala Pro Lys Lys Ile  Lys Leu Ala Ala Ala  Glu Gly Glu 
    2810                 2815                 2820             


Leu Lys  Ile Ala Met Asp Gly  Leu Arg Lys Lys Gln  Ala Ala Leu 
    2825                 2830                 2835             


Lys Glu  Val Gln Asp Lys Leu  Ala Arg Leu Gln Asp  Thr Leu Glu 
    2840                 2845                 2850             


Leu Asn  Lys Gln Lys Lys Ala  Asp Leu Glu Asn Gln  Val Asp Leu 
    2855                 2860                 2865             


Cys Ser  Lys Lys Leu Glu Arg  Ala Glu Gln Leu Ile  Gly Gly Leu 
    2870                 2875                 2880             


Gly Gly  Glu Lys Thr Arg Trp  Ser His Thr Ala Leu  Glu Leu Gly 
    2885                 2890                 2895             


Gln Leu  Tyr Ile Asn Leu Thr  Gly Asp Ile Leu Ile  Ser Ser Gly 
    2900                 2905                 2910             


Val Val  Ala Tyr Leu Gly Ala  Phe Thr Ser Thr Tyr  Arg Gln Asn 
    2915                 2920                 2925             


Gln Thr  Lys Glu Trp Thr Thr  Leu Cys Lys Gly Arg  Asp Ile Pro 
    2930                 2935                 2940             


Cys Ser  Asp Asp Cys Ser Leu  Met Gly Thr Leu Gly  Glu Ala Val 
    2945                 2950                 2955             


Thr Ile  Arg Thr Trp Asn Ile  Ala Gly Leu Pro Ser  Asp Ser Phe 
    2960                 2965                 2970             


Ser Ile  Asp Asn Gly Ile Ile  Ile Met Asn Ala Arg  Arg Trp Pro 
    2975                 2980                 2985             


Leu Met  Ile Asp Pro Gln Ser  Gln Ala Asn Lys Trp  Ile Lys Asn 
    2990                 2995                 3000             


Met Glu  Lys Ala Asn Ser Leu  Tyr Val Ile Lys Leu  Ser Glu Pro 
    3005                 3010                 3015             


Asp Tyr  Val Arg Thr Leu Glu  Asn Cys Ile Gln Phe  Gly Thr Pro 
    3020                 3025                 3030             


Val Leu  Leu Glu Asn Val Gly  Glu Glu Leu Asp Pro  Ile Leu Glu 
    3035                 3040                 3045             


Pro Leu  Leu Leu Lys Gln Thr  Phe Lys Gln Gly Gly  Ser Thr Cys 
    3050                 3055                 3060             


Ile Arg  Leu Gly Asp Ser Thr  Ile Glu Tyr Ala Pro  Asp Phe Arg 
    3065                 3070                 3075             


Phe Tyr  Ile Thr Thr Lys Leu  Arg Asn Pro His Tyr  Leu Pro Glu 
    3080                 3085                 3090             


Thr Ser  Val Lys Val Thr Leu  Leu Asn Phe Met Ile  Thr Pro Glu 
    3095                 3100                 3105             


Gly Met  Gln Asp Gln Leu Leu  Gly Ile Val Val Ala  Gln Glu Arg 
    3110                 3115                 3120             


Pro Asp  Leu Glu Glu Glu Lys  Gln Ala Leu Ile Leu  Gln Gly Ala 
    3125                 3130                 3135             


Glu Asn  Lys Arg Gln Leu Lys  Glu Ile Glu Asp Lys  Ile Leu Glu 
    3140                 3145                 3150             


Val Leu  Ser Ser Ser Glu Gly  Asn Ile Leu Glu Asp  Glu Thr Ala 
    3155                 3160                 3165             


Ile Lys  Ile Leu Ser Ser Ser  Lys Ala Leu Ala Asn  Glu Ile Ser 
    3170                 3175                 3180             


Gln Lys  Gln Glu Val Ala Glu  Glu Thr Glu Lys Lys  Ile Asp Thr 
    3185                 3190                 3195             


Thr Arg  Met Gly Tyr Arg Pro  Ile Ala Ile His Ser  Ser Ile Leu 
    3200                 3205                 3210             


Phe Phe  Ser Leu Ala Asp Leu  Ala Asn Ile Glu Pro  Met Tyr Gln 
    3215                 3220                 3225             


Tyr Ser  Leu Thr Trp Phe Ile  Asn Leu Phe Ile Leu  Ser Ile Glu 
    3230                 3235                 3240             


Asn Ser  Glu Lys Ser Glu Ile  Leu Ala Lys Arg Leu  Gln Ile Leu 
    3245                 3250                 3255             


Lys Asp  His Phe Thr Tyr Ser  Leu Tyr Val Asn Val  Cys Arg Ser 
    3260                 3265                 3270             


Leu Phe  Glu Lys Asp Lys Leu  Leu Phe Ser Phe Cys  Leu Thr Ile 
    3275                 3280                 3285             


Asn Leu  Leu Leu His Glu Arg  Ala Ile Asn Lys Ala  Glu Trp Arg 
    3290                 3295                 3300             


Phe Leu  Leu Thr Gly Gly Ile  Gly Leu Asp Asn Pro  Tyr Ala Asn 
    3305                 3310                 3315             


Leu Cys  Thr Trp Leu Pro Gln  Lys Ser Trp Asp Glu  Ile Cys Arg 
    3320                 3325                 3330             


Leu Asp  Asp Leu Pro Ala Phe  Lys Thr Ile Arg Arg  Glu Phe Met 
    3335                 3340                 3345             


Arg Leu  Lys Asp Gly Trp Lys  Lys Val Tyr Asp Ser  Leu Glu Pro 
    3350                 3355                 3360             


His His  Glu Val Phe Pro Glu  Glu Trp Glu Asp Lys  Ala Asn Glu 
    3365                 3370                 3375             


Phe Gln  Arg Met Leu Ile Ile  Arg Cys Leu Arg Pro  Asp Lys Val 
    3380                 3385                 3390             


Ile Pro  Met Leu Gln Glu Phe  Ile Ile Asn Arg Leu  Gly Arg Ala 
    3395                 3400                 3405             


Phe Ile  Glu Pro Pro Pro Phe  Asp Leu Ala Lys Ala  Phe Gly Asp 
    3410                 3415                 3420             


Ser Asn  Cys Cys Ala Pro Leu  Ile Phe Val Leu Ser  Pro Gly Ala 
    3425                 3430                 3435             


Asp Pro  Met Ala Ala Leu Leu  Lys Phe Ala Asp Asp  Gln Gly Tyr 
    3440                 3445                 3450             


Gly Gly  Ser Lys Leu Ser Ser  Leu Ser Leu Gly Gln  Gly Gln Gly 
    3455                 3460                 3465             


Pro Ile  Ala Met Lys Met Leu  Glu Lys Ala Val Lys  Glu Gly Thr 
    3470                 3475                 3480             


Trp Val  Val Leu Gln Asn Cys  His Leu Ala Thr Ser  Trp Met Pro 
    3485                 3490                 3495             


Thr Leu  Glu Lys Val Cys Glu  Glu Leu Ser Pro Glu  Ser Thr His 
    3500                 3505                 3510             


Pro Asp  Phe Arg Met Trp Leu  Thr Ser Tyr Pro Ser  Pro Asn Phe 
    3515                 3520                 3525             


Pro Val  Ser Val Leu Gln Asn  Gly Val Lys Met Thr  Asn Glu Ala 
    3530                 3535                 3540             


Pro Lys  Gly Leu Arg Ala Asn  Ile Ile Arg Ser Tyr  Leu Met Asp 
    3545                 3550                 3555             


Pro Ile  Ser Asp Pro Glu Phe  Phe Gly Ser Cys Lys  Lys Pro Glu 
    3560                 3565                 3570             


Glu Phe  Lys Lys Leu Leu Tyr  Gly Leu Cys Phe Phe  His Ala Leu 
    3575                 3580                 3585             


Val Gln  Glu Arg Arg Lys Phe  Gly Pro Leu Gly Trp  Asn Ile Pro 
    3590                 3595                 3600             


Tyr Glu  Phe Asn Glu Thr Asp  Leu Arg Ile Ser Val  Gln Gln Leu 
    3605                 3610                 3615             


His Met  Phe Leu Asn Gln Tyr  Glu Glu Leu Pro Tyr  Glu Ala Leu 
    3620                 3625                 3630             


Arg Tyr  Met Thr Gly Glu Cys  Asn Tyr Gly Gly Arg  Val Thr Asp 
    3635                 3640                 3645             


Asp Trp  Asp Arg Arg Thr Leu  Arg Ser Ile Leu Asn  Lys Phe Phe 
    3650                 3655                 3660             


Asn Pro  Glu Leu Val Glu Asn  Ser Asp Tyr Lys Phe  Asp Ser Ser 
    3665                 3670                 3675             


Gly Ile  Tyr Phe Val Pro Pro  Ser Gly Asp His Lys  Ser Tyr Ile 
    3680                 3685                 3690             


Glu Tyr  Thr Lys Thr Leu Pro  Leu Thr Pro Ala Pro  Glu Ile Phe 
    3695                 3700                 3705             


Gly Met  Asn Ala Asn Ala Asp  Ile Thr Lys Asp Gln  Ser Glu Thr 
    3710                 3715                 3720             


Gln Leu  Leu Phe Asp Asn Ile  Leu Leu Thr Gln Ser  Arg Ser Ala 
    3725                 3730                 3735             


Gly Ala  Gly Ala Lys Ser Ser  Asp Glu Val Val Asn  Glu Val Ala 
    3740                 3745                 3750             


Ser Asp  Ile Leu Gly Lys Leu  Pro Asn Asn Phe Asp  Ile Glu Ala 
    3755                 3760                 3765             


Ala Met  Arg Arg Tyr Pro Thr  Thr Tyr Thr Gln Ser  Met Asn Thr 
    3770                 3775                 3780             


Val Leu  Val Gln Glu Met Gly  Arg Phe Asn Lys Leu  Leu Lys Thr 
    3785                 3790                 3795             


Ile Arg  Asp Ser Cys Val Asn  Ile Gln Lys Ala Ile  Lys Gly Leu 
    3800                 3805                 3810             


Ala Val  Met Ser Thr Asp Leu  Glu Glu Val Val Ser  Ser Ile Leu 
    3815                 3820                 3825             


Asn Val  Lys Ile Pro Glu Met  Trp Met Gly Lys Ser  Tyr Pro Ser 
    3830                 3835                 3840             


Leu Lys  Pro Leu Gly Ser Tyr  Val Asn Asp Phe Leu  Ala Arg Leu 
    3845                 3850                 3855             


Lys Phe  Leu Gln Gln Trp Tyr  Glu Val Gly Pro Pro  Pro Val Phe 
    3860                 3865                 3870             


Trp Leu  Ser Gly Phe Phe Phe  Thr Gln Ala Phe Leu  Thr Gly Ala 
    3875                 3880                 3885             


Gln Gln  Asn Tyr Ala Arg Lys  Tyr Thr Ile Pro Ile  Asp Leu Leu 
    3890                 3895                 3900             


Gly Phe  Asp Tyr Glu Val Met  Glu Asp Lys Glu Tyr  Lys His Pro 
    3905                 3910                 3915             


Pro Glu  Asp Gly Val Phe Ile  His Gly Leu Phe Leu  Asp Gly Ala 
    3920                 3925                 3930             


Ser Trp  Asn Arg Lys Ile Lys  Lys Leu Ala Glu Ser  His Pro Lys 
    3935                 3940                 3945             


Ile Leu  Tyr Asp Thr Val Pro  Val Met Trp Leu Lys  Pro Cys Lys 
    3950                 3955                 3960             


Arg Ala  Asp Ile Pro Lys Arg  Pro Ser Tyr Val Ala  Pro Leu Tyr 
    3965                 3970                 3975             


Lys Thr  Ser Glu Arg Arg Gly  Val Leu Ser Thr Thr  Gly His Ser 
    3980                 3985                 3990             


Thr Asn  Phe Val Ile Ala Met  Thr Leu Pro Ser Asp  Gln Pro Lys 
    3995                 4000                 4005             


Glu His  Trp Ile Gly Arg Gly  Val Ala Leu Leu Cys  Gln Leu Asn 
    4010                 4015                 4020             


Ser 
    


<210> 5341
<211> 501
<212> PRT
<213> Homo sapiens

<400> 5341
Met Ser Ser Arg Gln Asp Lys Ser Ala Ser Lys Glu Lys Ser Lys Lys 
1               5                   10                  15      


Pro Val Arg Phe Leu Pro Gln Leu Ser Met Glu Lys Leu Ala Ser Lys 
            20                  25                  30          


Glu Lys Phe Lys Ala Pro Ala Arg Ala Leu Pro Gln Leu Ser Met Val 
        35                  40                  45              


Ser Thr Lys Pro His Trp Gln Gln Ala Ala Pro Ser Phe His Leu Ser 
    50                  55                  60                  


Val Lys Gln Asp Asp Glu Ser Pro Glu Pro Phe Ser Val Lys Asn Glu 
65                  70                  75                  80  


Gln Ser His Ala Glu Tyr Met Glu Arg Phe Gly Lys Lys Gly Lys Leu 
                85                  90                  95      


Pro His Gln Val Asp Asp Ser Tyr Val Gly Pro Ser Thr Ser Lys Ser 
            100                 105                 110         


Lys Gly Lys Ser Pro His Lys Glu Arg Glu Asn Phe Arg Ser Thr Leu 
        115                 120                 125             


Val Asn Val Ile Met Gln Gln Asp Ala Asp Leu Asp Ser Ala Val Pro 
    130                 135                 140                 


Asp Gly Ser Thr Ile Pro Lys Pro Thr Ala Ser Ala Ile Glu Lys Asp 
145                 150                 155                 160 


Ile Leu Arg Tyr Tyr Tyr Tyr Ile His His Gly Ile Asp Thr Asp His 
                165                 170                 175     


Val Ala Pro Met Glu Asp Ser Trp Leu Glu His Val Leu Asp Leu Val 
            180                 185                 190         


Pro Gln His Leu Lys Val Phe Thr Asp Ser Ile Val Thr Leu Ser Asp 
        195                 200                 205             


Glu Met Arg Glu Asp Tyr Leu Leu Ser Val Arg Lys Ser Ile Val Asp 
    210                 215                 220                 


Phe Val Leu Lys Asp Pro Arg Glu Lys Gly Asp Asp Lys Lys Thr Asp 
225                 230                 235                 240 


Glu Leu Pro Ala His Arg Ala Glu Met Glu Ile Leu Pro Lys Pro Trp 
                245                 250                 255     


Arg Lys Ser Phe Leu Ala Ala Ser Ser Tyr Ile Arg Asp His Leu Asn 
            260                 265                 270         


Ala Met Asn Pro Thr Met Leu Ala Val Leu Asp Leu Trp His Thr Asn 
        275                 280                 285             


Phe Lys Lys Leu Arg Leu Val Asp Ile Lys Glu Phe His Asn Cys Gln 
    290                 295                 300                 


Asp Ala Leu Glu Leu Ser Ser Phe Gln Asn Ile Ile Met Arg His Met 
305                 310                 315                 320 


Asp Ser Ala Lys Glu Thr Leu Leu Lys Met Trp Phe Pro Glu Val Gln 
                325                 330                 335     


Asn Ile Tyr Tyr Gln Gly Asn Lys Lys Lys Gln Leu Pro Thr Gly Asp 
            340                 345                 350         


Ser Ser Ala Lys Leu Glu Ser Phe Phe Asn Cys Ala Ala Ala Leu Met 
        355                 360                 365             


Thr Leu Gln Leu Gln Asp Leu Thr Leu Val Ser Met Gln Asp Phe Thr 
    370                 375                 380                 


Asp Leu Ile Ala Gln Pro Pro Asp Ser Val Arg Ala Phe Glu His Pro 
385                 390                 395                 400 


Gly Phe Ile Met Arg Leu Ile Leu Asp Asn Asp Thr Ile Lys Phe Glu 
                405                 410                 415     


Pro Glu Leu Ser Asp Tyr Ile Asp Ile Phe Leu Asn Val Tyr Asp Val 
            420                 425                 430         


Met Ile Lys Ala Val Ser Phe Val Pro Arg Val Glu Thr Lys Leu Tyr 
        435                 440                 445             


Ser Lys Trp Arg Asn Lys Ala Lys Pro Gly His Phe Tyr Phe Ser His 
    450                 455                 460                 


Ile Gln Arg Ser Val Thr Phe Gln His Ser Glu Val Ser Ser Pro Gln 
465                 470                 475                 480 


Asn Ser His Phe Lys Ile Val Ser Pro Phe Ser Val Leu Gly Phe Thr 
                485                 490                 495     


Trp Arg Cys Gln Leu 
            500     


<210> 5342
<211> 279
<212> PRT
<213> Homo sapiens

<400> 5342
Met Ala Ala Pro Val Arg Arg Thr Leu Leu Gly Val Ala Gly Gly Trp 
1               5                   10                  15      


Arg Arg Phe Glu Arg Leu Trp Ala Gly Ser Leu Ser Ser Arg Ser Leu 
            20                  25                  30          


Ala Leu Ala Ala Ala Pro Ser Ser Asn Gly Ser Pro Trp Arg Leu Leu 
        35                  40                  45              


Gly Ala Leu Cys Leu Gln Arg Pro Pro Val Val Ser Lys Pro Leu Thr 
    50                  55                  60                  


Pro Leu Gln Glu Glu Met Ala Ser Leu Leu Gln Gln Ile Glu Ile Glu 
65                  70                  75                  80  


Arg Ser Leu Tyr Ser Asp His Glu Leu Arg Ala Leu Asp Glu Asn Gln 
                85                  90                  95      


Arg Leu Ala Lys Lys Lys Ala Asp Leu His Asp Glu Glu Asp Glu Gln 
            100                 105                 110         


Asp Ile Leu Leu Ala Gln Asp Leu Glu Asp Met Trp Glu Gln Lys Phe 
        115                 120                 125             


Leu Gln Phe Lys Leu Gly Ala Arg Ile Thr Glu Ala Asp Glu Lys Asn 
    130                 135                 140                 


Asp Arg Thr Ser Leu Asn Arg Lys Leu Asp Arg Asn Leu Val Leu Leu 
145                 150                 155                 160 


Val Arg Glu Lys Phe Gly Asp Gln Asp Val Trp Ile Leu Pro Gln Ala 
                165                 170                 175     


Glu Trp Gln Pro Gly Glu Thr Leu Arg Gly Thr Ala Glu Arg Thr Leu 
            180                 185                 190         


Ala Thr Leu Ser Glu Asn Asn Met Glu Ala Lys Phe Leu Gly Asn Ala 
        195                 200                 205             


Pro Cys Gly His Tyr Thr Phe Lys Phe Pro Gln Ala Met Arg Thr Glu 
    210                 215                 220                 


Ser Asn Leu Gly Ala Lys Val Phe Phe Phe Lys Ala Leu Leu Leu Thr 
225                 230                 235                 240 


Gly Asp Phe Ser Gln Ala Gly Asn Lys Gly His His Val Trp Val Thr 
                245                 250                 255     


Lys Asp Glu Leu Gly Asp Tyr Leu Lys Pro Lys Tyr Leu Ala Gln Val 
            260                 265                 270         


Arg Arg Phe Val Ser Asp Leu 
        275                 


<210> 5343
<211> 202
<212> PRT
<213> Homo sapiens

<400> 5343
Met Glu Ala Glu Ala Gly Gly Leu Glu Glu Leu Thr Asp Glu Glu Met 
1               5                   10                  15      


Ala Ala Leu Gly Lys Glu Glu Leu Val Arg Arg Leu Arg Arg Glu Glu 
            20                  25                  30          


Ala Ala Arg Leu Ala Ala Leu Val Gln Arg Gly Arg Leu Met Gln Glu 
        35                  40                  45              


Val Asn Arg Gln Leu Gln Gly His Leu Gly Glu Ile Arg Glu Leu Lys 
    50                  55                  60                  


Gln Leu Asn Arg Arg Leu Gln Ala Glu Asn Arg Glu Leu Arg Asp Leu 
65                  70                  75                  80  


Cys Cys Phe Leu Asp Ser Glu Arg Gln Arg Gly Arg Arg Ala Ala Arg 
                85                  90                  95      


Gln Trp Gln Leu Phe Gly Thr Gln Ala Ser Arg Ala Val Arg Glu Asp 
            100                 105                 110         


Leu Gly Gly Cys Trp Gln Lys Leu Ala Glu Leu Glu Gly Arg Gln Glu 
        115                 120                 125             


Glu Leu Leu Arg Glu Asn Leu Ala Leu Lys Glu Leu Cys Leu Ala Leu 
    130                 135                 140                 


Gly Glu Glu Trp Gly Pro Arg Gly Gly Pro Ser Gly Ala Gly Gly Ser 
145                 150                 155                 160 


Gly Ala Gly Pro Ala Pro Glu Leu Ala Leu Pro Pro Cys Gly Pro Arg 
                165                 170                 175     


Asp Leu Gly Asp Gly Ser Ser Ser Thr Gly Ser Val Gly Ser Pro Asp 
            180                 185                 190         


Gln Leu Pro Leu Ala Cys Ser Pro Asp Asp 
        195                 200         


<210> 5344
<211> 450
<212> PRT
<213> Homo sapiens

<400> 5344
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Ser Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Val Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Leu 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Ala Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Ser Lys Lys Ser Lys Leu Glu Phe Ala Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Met Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Val His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Trp Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Lys Asp Cys 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu Gly Glu 
        435                 440                 445             


Ala Tyr 
    450 


<210> 5345
<211> 1025
<212> PRT
<213> Homo sapiens

<400> 5345
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser Glu 
    130                 135                 140                 


Ala Asp Val Arg Val Leu Glu Glu Gln Ala Gln Asn Leu Gly Leu Glu 
145                 150                 155                 160 


Gly Thr Leu Val Ser Leu Ala Arg Val Pro Gln Ala Arg Ala Val Arg 
                165                 170                 175     


Val Val Gly Asp Gly Ala Ser Val Asp Leu Leu Leu Leu Glu Leu Tyr 
            180                 185                 190         


Leu Glu Asn Glu Arg Arg Ser Gly Gly Gly Pro Leu Glu Asp Leu Gln 
        195                 200                 205             


Arg Leu Pro Gly Pro Leu Gly Thr Val Ala Ser Phe Gln Gln Trp Gln 
    210                 215                 220                 


Val Ala Glu Arg Val Leu Gln Gln Glu His Arg Leu Gln Gly Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Val Pro His Tyr Asp Ile Leu Glu Pro Glu Glu Leu Ala 
                245                 250                 255     


Glu Asn Thr Ser Gly Gly Asp His Pro Ser Thr Gln Gly Pro Arg Ala 
            260                 265                 270         


Thr Lys His Ala Leu Leu Arg Thr Gly Gly Leu Val Thr Ala Leu Gln 
        275                 280                 285             


Gly Ala Gly Thr Val Thr Met Gly Ser Gly Glu Glu Pro Gly Gln Ser 
    290                 295                 300                 


Gly Ala Ser Leu Arg Thr Gly Pro Met Val Gln Gly Arg Gly Ile Met 
305                 310                 315                 320 


Thr Thr Gly Ser Gly Gln Glu Pro Gly Gln Ser Gly Thr Ser Leu Arg 
                325                 330                 335     


Thr Gly Pro Met Gly Ser Leu Gly Gln Ala Glu Gln Val Ser Ser Met 
            340                 345                 350         


Pro Met Gly Ser Leu Glu His Glu Gly Leu Val Ser Leu Arg Pro Val 
        355                 360                 365             


Gly Leu Gln Glu Gln Glu Gly Pro Met Ser Leu Gly Pro Val Gly Ser 
    370                 375                 380                 


Ala Gly Pro Val Glu Thr Ser Lys Gly Leu Leu Gly Gln Glu Gly Leu 
385                 390                 395                 400 


Val Glu Ile Ala Met Asp Ser Pro Glu Gln Glu Gly Leu Val Gly Pro 
                405                 410                 415     


Met Glu Ile Thr Met Gly Ser Leu Glu Lys Ala Gly Pro Val Ser Pro 
            420                 425                 430         


Gly Cys Val Lys Leu Ala Gly Gln Glu Gly Leu Val Glu Met Val Leu 
        435                 440                 445             


Leu Met Glu Pro Gly Ala Met Arg Phe Leu Gln Leu Tyr His Glu Asp 
    450                 455                 460                 


Leu Leu Ala Gly Leu Gly Asp Val Ala Leu Leu Pro Leu Glu Gly Pro 
465                 470                 475                 480 


Asp Met Thr Gly Phe Arg Leu Cys Gly Ala Gln Ala Ser Cys Gln Ala 
                485                 490                 495     


Ala Glu Glu Phe Leu Arg Ser Leu Leu Gly Ser Ile Ser Cys His Val 
            500                 505                 510         


Leu Cys Leu Glu His Pro Gly Ser Ala Arg Phe Leu Leu Gly Pro Glu 
        515                 520                 525             


Gly Gln His Leu Leu Gln Gly Leu Glu Ala Gln Phe Gln Cys Val Phe 
    530                 535                 540                 


Gly Thr Glu Arg Leu Ala Thr Ala Thr Leu Asp Thr Gly Leu Glu Glu 
545                 550                 555                 560 


Val Asp Pro Thr Glu Ala Leu Pro Val Leu Pro Gly Asn Ala His Thr 
                565                 570                 575     


Leu Trp Thr Pro Asp Ser Thr Gly Gly Asp Gln Glu Asp Val Ser Leu 
            580                 585                 590         


Glu Glu Val Arg Glu Leu Leu Ala Thr Leu Glu Gly Leu Asp Leu Asp 
        595                 600                 605             


Gly Glu Asp Trp Leu Pro Arg Glu Leu Glu Glu Glu Gly Pro Gln Glu 
    610                 615                 620                 


Gln Pro Glu Glu Glu Val Thr Pro Gly His Glu Glu Glu Glu Pro Val 
625                 630                 635                 640 


Ala Pro Ser Thr Val Ala Pro Arg Trp Leu Glu Glu Glu Ala Ala Leu 
                645                 650                 655     


Gln Leu Ala Leu His Arg Ser Leu Glu Pro Gln Gly Gln Val Ala Glu 
            660                 665                 670         


Gln Glu Glu Ala Ala Ala Leu Arg Gln Ala Leu Thr Leu Ser Leu Leu 
        675                 680                 685             


Glu Gln Pro Pro Leu Glu Ala Glu Glu Pro Pro Asp Gly Gly Thr Asp 
    690                 695                 700                 


Gly Lys Ala Gln Leu Val Val His Ser Ala Phe Glu Gln Asp Val Glu 
705                 710                 715                 720 


Glu Leu Asp Arg Ala Leu Arg Ala Ala Leu Glu Val His Val Gln Glu 
                725                 730                 735     


Glu Thr Val Gly Pro Trp Arg Arg Thr Leu Pro Ala Glu Leu Arg Ala 
            740                 745                 750         


Arg Leu Glu Arg Cys His Gly Val Ser Val Ala Leu Arg Gly Asp Cys 
        755                 760                 765             


Thr Ile Leu Arg Gly Phe Gly Ala His Pro Ala Arg Ala Ala Arg His 
    770                 775                 780                 


Leu Val Ala Leu Leu Ala Gly Pro Trp Asp Gln Ser Leu Ala Phe Pro 
785                 790                 795                 800 


Leu Ala Ala Ser Gly Pro Thr Leu Ala Gly Gln Thr Leu Lys Gly Pro 
                805                 810                 815     


Trp Asn Asn Leu Glu Arg Leu Ala Glu Asn Thr Gly Glu Phe Gln Glu 
            820                 825                 830         


Val Val Arg Ala Phe Tyr Asp Thr Leu Asp Ala Ala Arg Ser Ser Ile 
        835                 840                 845             


Arg Val Val Arg Val Glu Arg Val Ser His Pro Leu Leu Gln Gln Gln 
    850                 855                 860                 


Tyr Glu Leu Tyr Arg Glu Arg Leu Leu Gln Arg Cys Glu Arg Arg Pro 
865                 870                 875                 880 


Val Glu Gln Val Leu Tyr His Gly Thr Thr Ala Pro Ala Val Pro Asp 
                885                 890                 895     


Ile Cys Ala His Gly Phe Asn Arg Ser Phe Cys Gly Arg Asn Ala Thr 
            900                 905                 910         


Val Tyr Gly Lys Gly Val Tyr Phe Ala Arg Arg Ala Ser Leu Ser Val 
        915                 920                 925             


Gln Asp Arg Tyr Ser Pro Pro Asn Ala Asp Gly His Lys Ala Val Phe 
    930                 935                 940                 


Val Ala Arg Val Leu Thr Gly Asp Tyr Gly Gln Gly Arg Arg Gly Leu 
945                 950                 955                 960 


Arg Ala Pro Pro Leu Arg Gly Pro Gly His Val Leu Leu Arg Tyr Asp 
                965                 970                 975     


Ser Ala Val Asp Cys Ile Cys Gln Pro Ser Ile Phe Val Ile Phe His 
            980                 985                 990         


Asp Thr Gln Ala Leu Pro Thr His  Leu Ile Thr Cys Glu  His Val Pro 
        995                 1000                 1005             


Arg Ala  Ser Pro Asp Asp Pro  Ser Gly Leu Pro Gly  Arg Ser Pro 
    1010                 1015                 1020             


Asp Thr  
    1025 


<210> 5346
<211> 129
<212> PRT
<213> Homo sapiens

<400> 5346
Met Ser His Leu Gln Ser Leu Leu Leu Asp Thr Leu Leu Gly Thr Lys 
1               5                   10                  15      


His Val Asp Ser Ala Ala Leu Ile Lys Ile Gln Glu Arg Ser Leu Cys 
            20                  25                  30          


Val Ala Ser Pro Gly Phe Asn Val Thr Pro Ser Asp Val Arg Thr Leu 
        35                  40                  45              


Val Asn Gly Phe Ala Lys Asn Pro Leu Gln Ala Arg Arg Glu Gly Leu 
    50                  55                  60                  


Tyr Phe Lys Gly Lys Asp Tyr Arg Cys Val Arg Ala Asp Glu Tyr Ser 
65                  70                  75                  80  


Leu Tyr Ala Lys Asn Glu Asn Thr Gly Val Val Val Val Lys Thr His 
                85                  90                  95      


Leu Tyr Leu Leu Val Ala Thr Tyr Thr Glu Gly Met Tyr Pro Ser Ile 
            100                 105                 110         


Cys Val Glu Ala Thr Glu Ser Leu Gly Asp Tyr Leu Arg Lys Lys Gly 
        115                 120                 125             


Ser 
    


<210> 5347
<211> 314
<212> PRT
<213> Homo sapiens

<400> 5347
Met Leu Gly Lys Gly Gly Lys Arg Lys Phe Asp Glu His Glu Asp Gly 
1               5                   10                  15      


Leu Glu Gly Lys Ile Val Ser Pro Cys Asp Gly Pro Ser Lys Val Ser 
            20                  25                  30          


Tyr Thr Leu Gln Arg Gln Thr Ile Phe Asn Ile Ser Leu Met Lys Leu 
        35                  40                  45              


Tyr Asn His Arg Pro Leu Thr Glu Pro Ser Leu Gln Lys Thr Val Leu 
    50                  55                  60                  


Ile Asn Asn Met Leu Arg Arg Ile Gln Glu Glu Leu Lys Gln Glu Gly 
65                  70                  75                  80  


Ser Leu Arg Pro Met Phe Thr Pro Ser Ser Gln Pro Thr Thr Glu Pro 
                85                  90                  95      


Ser Asp Ser Tyr Arg Glu Ala Pro Pro Ala Phe Ser His Leu Ala Ser 
            100                 105                 110         


Pro Ser Ser His Pro Cys Asp Leu Gly Ser Thr Thr Pro Leu Glu Ala 
        115                 120                 125             


Cys Leu Thr Pro Ala Ser Leu Leu Glu Asp Asp Asp Asp Thr Phe Cys 
    130                 135                 140                 


Thr Ser Gln Ala Met Gln Pro Thr Ala Pro Thr Lys Leu Ser Pro Pro 
145                 150                 155                 160 


Ala Leu Leu Pro Glu Lys Asp Ser Phe Ser Ser Ala Leu Asp Glu Ile 
                165                 170                 175     


Glu Glu Leu Cys Pro Thr Ser Thr Ser Thr Glu Ala Ala Thr Ala Ala 
            180                 185                 190         


Thr Asp Ser Val Lys Gly Thr Ser Ser Glu Ala Gly Thr Gln Lys Leu 
        195                 200                 205             


Asp Gly Pro Gln Glu Ser Arg Ala Asp Asp Ser Lys Leu Met Asp Ser 
    210                 215                 220                 


Leu Pro Gly Asn Phe Glu Ile Thr Thr Ser Thr Gly Phe Leu Thr Asp 
225                 230                 235                 240 


Leu Thr Leu Asp Asp Ile Leu Phe Ala Asp Ile Asp Thr Ser Met Tyr 
                245                 250                 255     


Asp Phe Asp Pro Cys Thr Ser Ser Ser Gly Thr Ala Ser Lys Met Ala 
            260                 265                 270         


Pro Val Ser Ala Asp Asp Leu Leu Lys Thr Leu Ala Pro Tyr Ser Ser 
        275                 280                 285             


Gln Pro Val Thr Pro Ser Gln Pro Phe Lys Met Asp Leu Thr Glu Leu 
    290                 295                 300                 


Asp His Ile Met Glu Val Leu Val Gly Ser 
305                 310                 


<210> 5348
<211> 81
<212> PRT
<213> Homo sapiens

<400> 5348
Met Lys Gly Ser Arg Ile Glu Leu Gly Asp Val Thr Pro His Asn Ile 
1               5                   10                  15      


Lys Gln Leu Lys Arg Leu Asn Gln Val Ile Phe Pro Val Ser Tyr Asn 
            20                  25                  30          


Asp Lys Phe Tyr Lys Lys Phe Gly Phe Glu Ile Ile Glu Thr Lys Lys 
        35                  40                  45              


Asn Tyr Tyr Lys Arg Ile Glu Pro Ala Asp Ala His Val Leu Gln Lys 
    50                  55                  60                  


Asn Leu Lys Val Pro Ser Gly Gln Asn Ala Asp Val Gln Lys Thr Asp 
65                  70                  75                  80  


Asn 
    


<210> 5349
<211> 478
<212> PRT
<213> Homo sapiens

<400> 5349
Met Ala Ser Ala Thr Glu Asp Pro Val Leu Glu Arg Tyr Phe Lys Gly 
1               5                   10                  15      


His Lys Ala Ala Ile Thr Ser Leu Asp Leu Ser Pro Asn Gly Lys Gln 
            20                  25                  30          


Leu Ala Thr Ala Ser Trp Asp Thr Phe Leu Met Leu Trp Asn Phe Lys 
        35                  40                  45              


Pro His Ala Arg Ala Tyr Arg Tyr Val Gly His Lys Asp Val Val Thr 
    50                  55                  60                  


Ser Val Gln Phe Ser Pro His Gly Asn Leu Leu Ala Ser Ala Ser Arg 
65                  70                  75                  80  


Asp Arg Thr Val Arg Leu Trp Ile Pro Asp Lys Arg Gly Lys Phe Ser 
                85                  90                  95      


Glu Phe Lys Ala His Thr Ala Pro Val Arg Ser Val Asp Phe Ser Ala 
            100                 105                 110         


Asp Gly Gln Phe Leu Ala Thr Ala Ser Glu Asp Lys Ser Ile Lys Val 
        115                 120                 125             


Trp Ser Met Tyr Arg Gln Arg Phe Leu Tyr Ser Leu Tyr Arg His Thr 
    130                 135                 140                 


His Trp Val Arg Cys Ala Lys Phe Ser Pro Asp Gly Arg Leu Ile Val 
145                 150                 155                 160 


Ser Cys Ser Glu Asp Lys Thr Ile Lys Ile Trp Asp Thr Thr Asn Lys 
                165                 170                 175     


Gln Cys Val Asn Asn Phe Ser Asp Ser Val Gly Phe Ala Asn Phe Val 
            180                 185                 190         


Asp Phe Asn Pro Ser Gly Thr Cys Ile Ala Ser Ala Gly Ser Asp Gln 
        195                 200                 205             


Thr Val Lys Val Trp Asp Val Arg Val Asn Lys Leu Leu Gln His Tyr 
    210                 215                 220                 


Gln Val His Ser Gly Gly Val Asn Cys Ile Ser Phe His Pro Ser Gly 
225                 230                 235                 240 


Asn Tyr Leu Ile Thr Ala Ser Ser Asp Gly Thr Leu Lys Ile Leu Asp 
                245                 250                 255     


Leu Leu Glu Gly Arg Leu Ile Tyr Thr Leu Gln Gly His Thr Gly Pro 
            260                 265                 270         


Val Phe Thr Val Ser Phe Ser Lys Gly Gly Glu Leu Phe Ala Ser Gly 
        275                 280                 285             


Gly Ala Asp Thr Gln Val Leu Leu Trp Arg Thr Asn Phe Asp Glu Leu 
    290                 295                 300                 


His Cys Lys Gly Leu Thr Lys Arg Asn Leu Lys Arg Leu His Phe Asp 
305                 310                 315                 320 


Ser Pro Pro His Leu Leu Asp Ile Tyr Pro Arg Thr Pro His Pro His 
                325                 330                 335     


Glu Glu Lys Val Glu Thr Val Glu Ile Asn Pro Lys Leu Glu Val Ile 
            340                 345                 350         


Asp Leu Gln Ile Ser Thr Pro Pro Val Met Asp Ile Leu Ser Phe Asp 
        355                 360                 365             


Ser Thr Thr Thr Thr Glu Thr Ser Gly Arg Thr Leu Pro Asp Lys Gly 
    370                 375                 380                 


Glu Glu Ala Cys Gly Tyr Phe Leu Asn Pro Ser Leu Met Ser Pro Glu 
385                 390                 395                 400 


Cys Leu Pro Thr Thr Thr Lys Lys Lys Thr Glu Asp Met Ser Asp Leu 
                405                 410                 415     


Pro Cys Glu Ser Gln Arg Ser Ile Pro Leu Ala Val Thr Asp Ala Leu 
            420                 425                 430         


Glu His Ile Met Glu Gln Leu Asn Val Leu Thr Gln Thr Val Ser Ile 
        435                 440                 445             


Leu Glu Gln Arg Leu Thr Leu Thr Glu Asp Lys Leu Lys Asp Cys Leu 
    450                 455                 460                 


Glu Asn Gln Gln Lys Leu Phe Ser Ala Val Gln Gln Lys Ser 
465                 470                 475             


<210> 5350
<211> 420
<212> PRT
<213> Homo sapiens

<400> 5350
Met Leu Lys Ala Val Ile Leu Ile Gly Gly Pro Gln Lys Gly Thr Arg 
1               5                   10                  15      


Phe Arg Pro Leu Ser Phe Glu Val Pro Lys Pro Leu Phe Pro Val Ala 
            20                  25                  30          


Gly Val Pro Met Ile Gln His His Ile Glu Ala Cys Ala Gln Val Pro 
        35                  40                  45              


Gly Met Gln Glu Ile Leu Leu Ile Gly Phe Tyr Gln Pro Asp Glu Pro 
    50                  55                  60                  


Leu Thr Gln Phe Leu Glu Ala Ala Gln Gln Glu Phe Asn Leu Pro Val 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Phe Ala Pro Leu Gly Thr Gly Gly Gly Leu Tyr 
                85                  90                  95      


His Phe Arg Asp Gln Ile Leu Ala Gly Ser Pro Glu Ala Phe Phe Val 
            100                 105                 110         


Leu Asn Ala Asp Val Cys Ser Asp Phe Pro Leu Ser Ala Met Leu Glu 
        115                 120                 125             


Ala His Arg Arg Gln Arg His Pro Phe Leu Leu Leu Gly Thr Thr Ala 
    130                 135                 140                 


Asn Arg Thr Gln Ser Leu Asn Tyr Gly Cys Ile Val Glu Asn Pro Gln 
145                 150                 155                 160 


Thr His Glu Val Leu His Tyr Val Glu Lys Pro Ser Thr Phe Ile Ser 
                165                 170                 175     


Asp Ile Ile Asn Cys Gly Ile Tyr Leu Phe Ser Pro Glu Ala Leu Lys 
            180                 185                 190         


Pro Leu Arg Asp Val Phe Gln Arg Asn Gln Gln Asp Gly Gln Leu Glu 
        195                 200                 205             


Asp Ser Pro Gly Leu Trp Pro Gly Ala Gly Thr Ile Arg Leu Glu Gln 
    210                 215                 220                 


Asp Val Phe Ser Ala Leu Ala Gly Gln Gly Gln Ile Tyr Val His Leu 
225                 230                 235                 240 


Thr Asp Gly Ile Trp Ser Gln Ile Lys Ser Ala Gly Ser Ala Leu Tyr 
                245                 250                 255     


Ala Ser Arg Leu Tyr Leu Ser Arg Tyr Gln Asp Thr His Pro Glu Arg 
            260                 265                 270         


Leu Ala Lys His Thr Pro Gly Gly Pro Trp Ile Arg Gly Asn Val Tyr 
        275                 280                 285             


Ile His Pro Thr Ala Lys Val Ala Pro Ser Ala Val Leu Gly Pro Asn 
    290                 295                 300                 


Val Ser Ile Gly Lys Gly Val Thr Val Gly Glu Gly Val Arg Leu Arg 
305                 310                 315                 320 


Glu Ser Ile Val Leu His Gly Ala Thr Leu Gln Glu His Thr Cys Val 
                325                 330                 335     


Leu His Ser Ile Val Gly Trp Gly Ser Thr Val Gly Arg Trp Ala Arg 
            340                 345                 350         


Val Glu Gly Thr Pro Ser Asp Pro Asn Pro Asn Asp Pro Arg Ala Arg 
        355                 360                 365             


Met Asp Ser Glu Ser Leu Phe Lys Asp Gly Lys Leu Leu Pro Ala Ile 
    370                 375                 380                 


Thr Ile Leu Gly Cys Arg Val Arg Ile Pro Ala Glu Val Leu Ile Leu 
385                 390                 395                 400 


Asn Ser Ile Val Leu Pro His Lys Glu Leu Ser Arg Ser Phe Thr Asn 
                405                 410                 415     


Gln Ile Ile Leu 
            420 


<210> 5351
<211> 404
<212> PRT
<213> Homo sapiens

<400> 5351
Met Asp Gln Asp Tyr Glu Arg Arg Leu Leu Arg Gln Ile Val Ile Gln 
1               5                   10                  15      


Asn Glu Asn Thr Met Pro Arg Val Thr Glu Met Arg Arg Thr Leu Thr 
            20                  25                  30          


Pro Ala Ser Ser Pro Val Ser Ser Pro Ser Lys His Gly Asp Arg Phe 
        35                  40                  45              


Ile Pro Ser Arg Ala Gly Ala Asn Trp Ser Val Asn Phe His Arg Ile 
    50                  55                  60                  


Asn Glu Asn Glu Lys Ser Pro Ser Gln Asn Arg Lys Ala Lys Asp Ala 
65                  70                  75                  80  


Thr Ser Asp Asn Gly Lys Asp Gly Leu Ala Tyr Ser Ala Leu Leu Lys 
                85                  90                  95      


Asn Glu Leu Leu Gly Ala Gly Ile Glu Lys Val Gln Asp Pro Gln Thr 
            100                 105                 110         


Glu Asp Arg Arg Leu Gln Pro Ser Thr Pro Glu Lys Lys Gly Leu Phe 
        115                 120                 125             


Thr Val Thr Arg Leu Cys Asp Leu Ser Val Glu Gly Asp Ser Val Thr 
    130                 135                 140                 


Ser Val Gly Trp Ser Glu Arg Gly Asn Leu Val Ala Val Gly Thr His 
145                 150                 155                 160 


Lys Gly Phe Val Gln Ile Trp Asp Ala Ala Ala Gly Lys Lys Leu Ser 
                165                 170                 175     


Met Leu Glu Gly His Thr Ala Arg Val Gly Ala Leu Ala Trp Asn Ala 
            180                 185                 190         


Glu Gln Leu Ser Ser Gly Ser Arg Asp Arg Met Ile Leu Gln Arg Asp 
        195                 200                 205             


Ile Arg Thr Pro Pro Leu Gln Ser Glu Arg Arg Leu Gln Gly His Arg 
    210                 215                 220                 


Gln Glu Val Cys Gly Leu Lys Trp Ser Thr Asp His Gln Leu Leu Ala 
225                 230                 235                 240 


Ser Gly Gly Asn Asp Asn Lys Leu Leu Val Trp Asn His Ser Ser Leu 
                245                 250                 255     


Ser Pro Val Gln Gln Tyr Thr Glu His Leu Ala Ala Val Lys Ala Ile 
            260                 265                 270         


Ala Trp Ser Pro His Gln His Gly Leu Leu Ala Ser Gly Gly Gly Thr 
        275                 280                 285             


Ala Asp Arg Cys Ile Arg Phe Trp Asn Thr Leu Thr Gly Gln Pro Leu 
    290                 295                 300                 


Gln Cys Ile Asp Thr Gly Ser Gln Val Cys Asn Leu Ala Trp Ser Lys 
305                 310                 315                 320 


His Ala Asn Glu Leu Val Ser Thr His Gly Tyr Ser Gln Asn Gln Ile 
                325                 330                 335     


Leu Val Trp Lys Tyr Pro Ser Leu Thr Gln Val Ala Lys Leu Thr Gly 
            340                 345                 350         


His Ser Tyr Arg Val Leu Tyr Leu Ala Met Ser Pro Asp Gly Glu Ala 
        355                 360                 365             


Ile Val Thr Gly Ala Gly Asp Glu Thr Leu Arg Phe Trp Asn Val Phe 
    370                 375                 380                 


Ser Lys Thr Arg Ser Thr Lys Glu Ser Val Ser Val Leu Asn Leu Phe 
385                 390                 395                 400 


Thr Arg Ile Arg 
                


<210> 5352
<211> 1963
<212> PRT
<213> Homo sapiens

<400> 5352
Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Thr Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Thr Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Thr Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Thr Ser Asp Gly Thr Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Thr Glu Pro Lys Ala Val Arg Thr Thr Thr Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Thr Ser Tyr Leu Thr Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Thr Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Thr His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Thr Ile Val Ser Ser Thr Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Thr Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Thr Thr Asp Met Thr Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Thr Glu Pro Ser Ser Thr Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Thr Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Thr Thr Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Thr Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Thr Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Thr Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Thr Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Thr Ser Met Leu Leu Asp Gln Val His Pro Pro 
            340                 345                 350         


Ile Asn Glu Asp Ser Leu Arg Ala Ser Thr Gln Ile Arg Ala Phe Ser 
        355                 360                 365             


Arg Asn Arg Phe Lys Asp His Ile Glu Asp His Leu Leu Pro Ser Thr 
    370                 375                 380                 


Glu Asn Thr Phe Trp Arg His Asp Thr Lys Ala Asp Thr Arg Ala Ile 
385                 390                 395                 400 


Gln Leu Leu Leu Gly Ser Ala Glu Leu Ser Gln Gly Asn Phe Trp Asp 
                405                 410                 415     


Gly Leu Gly Ser Pro Pro Asp Ser Pro Ser Pro Gly Ser Asp Val Tyr 
            420                 425                 430         


Cys Ile Ser Glu Leu Asn Asp Pro Gln Tyr Asp Gln Ser Leu Leu Glu 
        435                 440                 445             


Asn Leu Phe Tyr Thr Ala Pro Lys Ser Asp Thr Ser Ile Ser Asp Phe 
    450                 455                 460                 


Leu Ser Glu Glu Asp Asp Ile Val Pro Ser Lys Lys Ile Ser Gln Ser 
465                 470                 475                 480 


Thr Ala Leu Ala Arg Ser Ser Lys Val Leu Glu Ser Ser Asp His Lys 
                485                 490                 495     


Leu Lys Lys Arg Ser Ala Gly Lys Arg Asn Arg Asn Leu Val Glu Gln 
            500                 505                 510         


Gln Met Leu Ser Glu Thr Pro Glu Asp Ala Gln Thr Met Thr Leu Ser 
        515                 520                 525             


Val Asp Arg Leu Ala Leu Leu Gly Arg Thr His Ser Val Arg Ile Ile 
    530                 535                 540                 


Ile Glu Thr Met Gly Val Pro Pro Asp Ser Pro Gln Met Thr Pro Gly 
545                 550                 555                 560 


Lys Lys Ser Tyr Ala Gly Pro Pro Pro Lys Val Thr Thr Ala Lys Lys 
                565                 570                 575     


Arg Thr Phe Phe Val Glu Tyr His Phe Pro Val Gly Phe Ser Glu Ser 
            580                 585                 590         


Gly Leu Gly Lys Thr Ala Leu Ile Thr Glu Val Val Arg Leu Ala Ser 
        595                 600                 605             


Ser Lys Ile Thr Asp Gly Lys Val Lys Phe Gln Gln Arg Phe Val Phe 
    610                 615                 620                 


Pro Val Gln Phe Gly Gly Pro Met Ile Glu His Trp Trp Asn Ser Asn 
625                 630                 635                 640 


Leu Thr Phe Gln Ile Tyr Val Lys Lys Thr Pro Gln Lys Lys Pro Glu 
                645                 650                 655     


Val Ile Gly Ser Val Ser Leu Ser Leu Arg Ala Val Ile Gln Ser Glu 
            660                 665                 670         


Leu Leu Ser Phe Ser Asp Gln Leu Pro Val Gln Gln Glu Asn Gly Gln 
        675                 680                 685             


Ser Pro Phe Gly Pro Leu Lys Val Thr Met Glu Leu Ile Thr Asp Asn 
    690                 695                 700                 


Lys Asp Phe Thr Gly Ile Asn Thr Lys Leu Ser Gly Asn Thr His Tyr 
705                 710                 715                 720 


Thr Pro Leu Cys Ala Pro Thr Ser Pro Asn Lys Ala Leu Pro Glu Leu 
                725                 730                 735     


Asn Gln Asp Met Thr Cys Thr Lys Asn Pro Gln Asn Leu Asn Gln Ile 
            740                 745                 750         


His Glu Glu Thr Ala Lys Lys Ala Gln Asn Leu Val Leu Pro Asn Arg 
        755                 760                 765             


Lys Ser Pro Ser Pro Val Ala Pro His Pro Ser Thr Phe Val Ala Thr 
    770                 775                 780                 


Pro Ala Ser His Asn Leu Val Asn Gln Thr Asn Gly Thr Thr Lys Glu 
785                 790                 795                 800 


Ser Ala Leu Leu Leu His Val Leu Leu Met Val Pro Asp Gly Lys Asp 
                805                 810                 815     


Phe Ile Ser Gly Glu Ser Glu Lys Gln Ser Pro Cys Asn Val Tyr Leu 
            820                 825                 830         


Asn Cys Lys Leu Phe Ser Thr Glu Glu Val Thr Arg Ser Val Ile Ala 
        835                 840                 845             


Trp Gly Thr Thr Gln Pro Val Phe Asn Phe Ser Gln Val Ile Pro Val 
    850                 855                 860                 


Ser Leu Ser Ser Lys Tyr Leu Glu Arg Leu Lys Asn Asn Val Met Val 
865                 870                 875                 880 


Ile Glu Thr Trp Asn Lys Val Arg Ser Pro Gly Gln Asp Lys Leu Leu 
                885                 890                 895     


Gly Leu Val Lys Leu Pro Leu His Gln Phe Tyr Met Ser Phe Lys Asp 
            900                 905                 910         


Ala Lys Ile Ser Arg Leu Leu Leu Asp Ala Gln Tyr Pro Val Val Ala 
        915                 920                 925             


Val Asp Ser Tyr Met Pro Val Ile Asp Val Phe Ser Gly His Gln Asn 
    930                 935                 940                 


Gly Ser Leu Arg Val Phe Leu Ala Met Gly Ser Ser Asn Gln Ile Met 
945                 950                 955                 960 


Ala Leu Gln Arg Leu Lys Asn Glu Glu Gly Thr Leu Pro Pro Phe Ser 
                965                 970                 975     


Pro Arg Pro Ala His Phe Leu Asp Gln Pro Thr Ala Ala Ser Val Ala 
            980                 985                 990         


Met Ala Glu Asp Arg Gly Asn Gly  Leu Met Glu His Cys  Phe Glu Ile 
        995                 1000                 1005             


His Ile  Glu Met Val Lys Gly  Leu Ala Pro Leu Gln  Ala Thr Val 
    1010                 1015                 1020             


Trp Gly  Glu Ala Asp Cys Tyr  Val Gln Tyr Tyr Phe  Pro Val Gln 
    1025                 1030                 1035             


His Ser  Gln Ser Ser Val Leu  Lys Gly Pro Glu Phe  Leu Glu Asn 
    1040                 1045                 1050             


Gly Ile  Thr Leu Lys Pro Phe  Arg Thr Ala Thr Thr  Leu Cys Val 
    1055                 1060                 1065             


Pro Asp  Pro Ile Phe Asn Ser  Glu His His His Ser  Leu Leu Leu 
    1070                 1075                 1080             


Pro Ala  Glu Val Pro Val Gln  Arg Leu Leu Leu Ser  Ala Phe Ser 
    1085                 1090                 1095             


Ala Gln  Gly Leu Val Pro Gly  Gly Gly Val Gln Phe  Glu Ile Trp 
    1100                 1105                 1110             


Cys Arg  Tyr Tyr Tyr Pro Asn  Val Arg Asp Gln Lys  Val Ala Lys 
    1115                 1120                 1125             


Gly Thr  Leu Pro Leu Ser Arg  Ile Cys Ala Met Val  Thr Thr Gln 
    1130                 1135                 1140             


His Arg  Glu Asp Val Gly Ile  Gln Thr Phe Asn Leu  Pro Leu Thr 
    1145                 1150                 1155             


Pro Arg  Ile Glu Asn Arg Lys  Glu Leu Arg Asn Gln  Ser Ser Gly 
    1160                 1165                 1170             


Leu Leu  Asp Val Gly Leu Arg  Tyr Arg Arg Ser Pro  Arg Thr Ala 
    1175                 1180                 1185             


Glu Gly  Val Leu Ala Ala Arg  Thr Val Ser Ile Ser  Val Gln Ile 
    1190                 1195                 1200             


Ile Arg  Ala Cys Gly Leu Gln  Ala Ala Ala Lys Ala  Leu Ala Glu 
    1205                 1210                 1215             


Arg Glu  Pro Ala Leu Gln Phe  Ser Ala Thr Val Gly  Val Asn Ala 
    1220                 1225                 1230             


Ser Val  Thr Thr His Leu Ser  Phe Leu Pro Gln Gly  Glu Gln Arg 
    1235                 1240                 1245             


Arg Thr  His Pro Val Ala Cys  Ser Phe Cys Pro Glu  Phe Ser His 
    1250                 1255                 1260             


His Val  Glu Phe Thr Cys Asn  Leu Val Thr Gln His  Cys Ser Gly 
    1265                 1270                 1275             


Glu Ala  Cys Phe Leu Ala Glu  Leu Leu Glu Phe Ala  Glu Val Ile 
    1280                 1285                 1290             


Phe Ala  Val Tyr His Glu Asn  Thr Lys Ser Ala Ser  Asp Ile Ile 
    1295                 1300                 1305             


Ser Ile  Glu Ser Cys Lys Glu  Tyr Leu Leu Gly Val  Val Lys Val 
    1310                 1315                 1320             


Pro Thr  Lys Glu Leu Leu Ile  Lys Arg Ser Gly Ile  Thr Gly Trp 
    1325                 1330                 1335             


Tyr Pro  Ile Ile Leu Pro Glu  Asp Gly Gly Leu Pro  His Gly Leu 
    1340                 1345                 1350             


Glu Leu  Met Gln Lys Ile Val  Gly Gly Leu Glu Leu  Ser Ile Ser 
    1355                 1360                 1365             


Phe Thr  His Arg Gly Asp Arg  Glu Arg Val Leu Glu  Ala Ala Glu 
    1370                 1375                 1380             


His Leu  Gly Trp Ser Phe Glu  Asn Ser Leu Lys Asp  Phe Val Arg 
    1385                 1390                 1395             


Met Asp  Glu Gly Glu Pro Ala  Thr Val Thr Ile Ser  Thr Pro Arg 
    1400                 1405                 1410             


Leu Trp  Leu Pro Ile His Cys  Val Leu Leu Ala Gly  His Asn His 
    1415                 1420                 1425             


Ile His  Lys Asn Thr Tyr Cys  Tyr Leu Arg Tyr Lys  Phe Tyr Asp 
    1430                 1435                 1440             


His Glu  Ala Phe Trp Thr Pro  Leu Lys Lys Pro Lys  Glu Ser Val 
    1445                 1450                 1455             


Asn Lys  Lys Gln Ile Met Val  Thr Phe Lys Ala Ser  Lys Arg Ala 
    1460                 1465                 1470             


Glu Val  Thr Arg Gly Pro Ser  Leu Leu Trp Tyr Phe  Arg Glu Glu 
    1475                 1480                 1485             


Arg Leu  Glu Ile Gln Val Trp  Arg Ala Tyr Gly Asn  Asp Ser Val 
    1490                 1495                 1500             


Glu Arg  Pro His Gln Thr Asp  Ser Trp Ile Gly Ser  Ala Tyr Val 
    1505                 1510                 1515             


Asp Leu  Ala Arg Leu Gly Glu  Arg Ser Ala Arg Thr  Leu Thr Val 
    1520                 1525                 1530             


Ser Gly  Val Tyr Pro Leu Phe  Gly Arg Asn Ala Ser  Asn Leu Ser 
    1535                 1540                 1545             


Gly Ala  Ala Leu Arg Val His  Val Val Leu Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


His Leu  Glu Pro Thr His Glu  Leu Asp Ser Met Asp  Cys Ser Ser 
    1565                 1570                 1575             


His Ser  Glu Ser Glu Gln Leu  Pro Arg Arg Asn Asp  Glu Val Gln 
    1580                 1585                 1590             


Leu Ser  Pro Pro Glu Val Ile  Ser Cys His Gln Lys  Ser Pro Ala 
    1595                 1600                 1605             


Ser Thr  Gln Val Pro Cys Ser  Ser Thr Thr Ala Glu  Val Arg Leu 
    1610                 1615                 1620             


Thr Gln  Glu Gly Pro Ala Asp  Leu Asp Gly Thr Phe  Ala Val Ser 
    1625                 1630                 1635             


Ile Leu  Val Glu Arg Ala Met  His Leu Ser Leu Lys  Gly Ser Pro 
    1640                 1645                 1650             


Leu Thr  Glu Arg Lys Val Ser  Ile Pro Ser Cys Cys  Val Ser Phe 
    1655                 1660                 1665             


Ala Thr  Ala Asp Glu Ser Ser  Pro Val Tyr Thr Gln  Val Val Glu 
    1670                 1675                 1680             


Asn Thr  Asp Ser Pro Ile Trp  Asn Phe Gln Gln Gln  Ser Arg Leu 
    1685                 1690                 1695             


Ser Lys  Glu Leu Leu Leu Asp  Pro Gln Gln Thr Leu  Val Phe Lys 
    1700                 1705                 1710             


Val Trp  His Lys Gly Asp Glu  Glu Arg Val Ile Gly  Phe Ala Ser 
    1715                 1720                 1725             


Val Asp  Leu Ser Pro Leu Leu  Ser Gly Phe Gln Phe  Val Cys Gly 
    1730                 1735                 1740             


Trp Tyr  Asn Ile Thr Asp Phe  Ser Gly Glu Cys Gln  Gly Gln Ile 
    1745                 1750                 1755             


Lys Val  Ala Val Ser Pro Leu  Glu Ser Leu Ile His  Phe Lys Glu 
    1760                 1765                 1770             


Glu Arg  Gln Ala Arg Arg Gly  Val Glu Thr Ser Lys  Ser Leu Ile 
    1775                 1780                 1785             


Pro Ile  Tyr Ser Pro Phe Ser  Phe Pro Ala Ser Asp  Thr Tyr Ala 
    1790                 1795                 1800             


Ala Phe  Ser Ser His Met Ala  Arg Gln Thr Leu Asp  Gln Leu Ala 
    1805                 1810                 1815             


His Ala  Ser Ser Lys Glu Leu  Asp Phe Ser Ser Pro  Gly Arg Ser 
    1820                 1825                 1830             


Asp Thr  Thr Arg Ser Gln Ala  Ser Arg His Glu Glu  His Val Gln 
    1835                 1840                 1845             


Asn Ile  Arg Arg Phe His Glu  Ser Leu His Leu Gln  Gly Glu Ala 
    1850                 1855                 1860             


Pro Leu  Pro Cys Asp Asp Lys  Leu Thr Thr Ser Pro  Leu Ser Ser 
    1865                 1870                 1875             


Gln Thr  Ser Ile Leu Thr Ser  Leu Arg Lys Asn Leu  Ser Glu Leu 
    1880                 1885                 1890             


Asp Gln  Ile Gln Arg Tyr Phe  Arg Gln Lys Leu Thr  Lys Pro Phe 
    1895                 1900                 1905             


Leu Pro  Leu Ser Pro Gln Thr  Gln Thr Ala Ile Ser  Gln His Gln 
    1910                 1915                 1920             


Glu Ser  Cys Arg Asp His Leu  Gly Pro Gly Ala Ser  Ser Leu Asp 
    1925                 1930                 1935             


Pro Gly  Ser Gln Cys Ile Leu  Glu Lys Ser Ser Asn  Leu Val Leu 
    1940                 1945                 1950             


Gln Val  Ser Ser Leu Ile Thr  Gly Ser Tyr 
    1955                 1960             


<210> 5353
<211> 1861
<212> PRT
<213> Homo sapiens

<400> 5353
Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Thr Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Thr Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Thr Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Thr Ser Asp Gly Thr Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Thr Glu Pro Lys Ala Val Arg Thr Thr Thr Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Thr Ser Tyr Leu Thr Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Thr Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Thr His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Thr Ile Val Ser Ser Thr Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Thr Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Thr Thr Asp Met Thr Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Thr Glu Pro Ser Ser Thr Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Thr Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Thr Thr Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Thr Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Thr Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Thr Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Thr Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Thr Ser Met Leu Leu Asp Gln Val His Pro Pro 
            340                 345                 350         


Ile Asn Glu Asp Ser Leu Arg Ala Ser Thr Gln Ile Arg Ala Phe Ser 
        355                 360                 365             


Arg Asn Arg Phe Lys Asp His Ile Glu Asp His Leu Leu Pro Ser Thr 
    370                 375                 380                 


Glu Asn Thr Phe Trp Arg His Asp Thr Lys Ala Asp Thr Arg Ala Ile 
385                 390                 395                 400 


Gln Leu Leu Leu Gly Ser Ala Glu Leu Ser Gln Gly Asn Phe Trp Asp 
                405                 410                 415     


Gly Leu Gly Ser Pro Pro Asp Ser Pro Ser Pro Gly Ser Asp Val Tyr 
            420                 425                 430         


Cys Ile Ser Glu Leu Asn Asp Pro Gln Tyr Asp Gln Ser Leu Leu Glu 
        435                 440                 445             


Asn Leu Phe Tyr Thr Ala Pro Lys Ser Asp Thr Ser Ile Ser Asp Phe 
    450                 455                 460                 


Leu Ser Glu Glu Asp Asp Ile Val Pro Ser Lys Lys Ile Ser Gln Ser 
465                 470                 475                 480 


Thr Ala Leu Ala Arg Ser Ser Lys Val Leu Glu Ser Ser Asp His Lys 
                485                 490                 495     


Leu Lys Lys Arg Ser Ala Gly Lys Arg Asn Arg Asn Leu Val Glu Gln 
            500                 505                 510         


Gln Met Leu Ser Glu Thr Pro Glu Asp Ala Gln Thr Met Thr Leu Ser 
        515                 520                 525             


Val Asp Arg Leu Ala Leu Leu Gly Arg Thr His Ser Val Arg Ile Ile 
    530                 535                 540                 


Ile Glu Thr Met Gly Val Pro Pro Asp Ser Pro Gln Met Thr Pro Gly 
545                 550                 555                 560 


Lys Lys Ser Tyr Ala Gly Pro Pro Pro Lys Val Thr Thr Ala Lys Lys 
                565                 570                 575     


Arg Thr Phe Phe Val Glu Tyr His Phe Pro Val Gly Phe Ser Glu Ser 
            580                 585                 590         


Gly Leu Gly Lys Thr Ala Leu Ile Thr Glu Val Val Arg Leu Ala Ser 
        595                 600                 605             


Ser Lys Ile Thr Asp Gly Lys Val Lys Phe Gln Gln Arg Phe Val Phe 
    610                 615                 620                 


Pro Val Gln Phe Gly Gly Pro Met Ile Glu His Trp Trp Asn Ser Asn 
625                 630                 635                 640 


Leu Thr Phe Gln Ile Tyr Val Lys Lys Thr Pro Gln Lys Lys Pro Glu 
                645                 650                 655     


Val Ile Gly Ser Val Ser Leu Ser Leu Arg Ala Val Ile Gln Ser Glu 
            660                 665                 670         


Leu Leu Ser Phe Ser Asp Gln Leu Pro Val Gln Gln Glu Asn Gly Gln 
        675                 680                 685             


Ser Pro Phe Gly Pro Leu Lys Val Thr Met Glu Leu Ile Thr Asp Asn 
    690                 695                 700                 


Lys Asp Phe Thr Gly Ile Asn Thr Lys Leu Ser Gly Asn Thr His Tyr 
705                 710                 715                 720 


Thr Pro Leu Cys Ala Pro Thr Ser Pro Asn Lys Ala Leu Pro Glu Leu 
                725                 730                 735     


Asn Gln Asp Met Thr Cys Thr Lys Asn Pro Gln Asn Leu Asn Gln Ile 
            740                 745                 750         


His Glu Glu Thr Ala Lys Lys Ala Gln Asn Leu Val Leu Pro Asn Arg 
        755                 760                 765             


Lys Ser Pro Ser Pro Val Ala Pro His Pro Ser Thr Phe Val Ala Thr 
    770                 775                 780                 


Pro Ala Ser His Asn Leu Val Asn Gln Thr Asn Gly Thr Thr Lys Glu 
785                 790                 795                 800 


Ser Ala Leu Leu Leu His Val Leu Leu Met Val Pro Asp Gly Lys Asp 
                805                 810                 815     


Phe Ile Ser Gly Glu Ser Glu Lys Gln Ser Pro Cys Asn Val Tyr Leu 
            820                 825                 830         


Asn Cys Lys Leu Phe Ser Thr Glu Glu Val Thr Arg Ser Val Ile Ala 
        835                 840                 845             


Trp Gly Thr Thr Gln Pro Val Phe Asn Phe Ser Gln Val Ile Pro Val 
    850                 855                 860                 


Ser Leu Ser Ser Lys Tyr Leu Glu Arg Leu Lys Asn Asn Val Met Val 
865                 870                 875                 880 


Ile Glu Thr Trp Asn Lys Val Arg Ser Pro Gly Gln Asp Lys Leu Leu 
                885                 890                 895     


Gly Leu Val Lys Leu Pro Leu His Gln Phe Tyr Met Ser Phe Lys Asp 
            900                 905                 910         


Ala Lys Ile Ser Arg Leu Leu Leu Asp Ala Gln Tyr Pro Val Val Ala 
        915                 920                 925             


Val Asp Ser Tyr Met Pro Val Ile Asp Val Phe Ser Gly His Gln Asn 
    930                 935                 940                 


Gly Ser Leu Arg Val Phe Leu Ala Met Gly Ser Ser Asn Gln Ile Met 
945                 950                 955                 960 


Ala Leu Gln Arg Leu Lys Asn Glu Glu Gly Thr Leu Pro Pro Phe Ser 
                965                 970                 975     


Pro Arg Pro Ala His Phe Leu Asp Gln Pro Thr Ala Ala Ser Val Ala 
            980                 985                 990         


Met Ala Glu Asp Arg Gly Asn Gly  Leu Met Glu His Cys  Phe Glu Ile 
        995                 1000                 1005             


His Ile  Glu Met Val Lys Gly  Leu Ala Pro Leu Gln  Ala Thr Val 
    1010                 1015                 1020             


Trp Gly  Glu Ala Asp Cys Tyr  Val Gln Tyr Tyr Phe  Pro Val Gln 
    1025                 1030                 1035             


His Ser  Gln Ser Ser Val Leu  Lys Gly Pro Glu Phe  Leu Glu Asn 
    1040                 1045                 1050             


Gly Ile  Thr Leu Lys Pro Phe  Arg Thr Ala Thr Thr  Leu Cys Val 
    1055                 1060                 1065             


Pro Asp  Pro Ile Phe Asn Ser  Glu His His His Ser  Leu Leu Leu 
    1070                 1075                 1080             


Pro Ala  Glu Val Pro Val Gln  Arg Leu Leu Leu Ser  Ala Phe Ser 
    1085                 1090                 1095             


Ala Gln  Gly Leu Val Pro Gly  Gly Gly Val Gln Phe  Glu Ile Trp 
    1100                 1105                 1110             


Cys Arg  Tyr Tyr Tyr Pro Asn  Val Arg Asp Gln Lys  Val Ala Lys 
    1115                 1120                 1125             


Gly Thr  Leu Pro Leu Ser Arg  Ile Cys Ala Met Val  Thr Thr Gln 
    1130                 1135                 1140             


His Arg  Glu Asp Val Gly Ile  Gln Thr Phe Asn Leu  Pro Leu Thr 
    1145                 1150                 1155             


Pro Arg  Ile Glu Asn Arg Lys  Glu Leu Arg Asn Gln  Ser Ser Gly 
    1160                 1165                 1170             


Leu Leu  Asp Val Gly Leu Arg  Tyr Arg Arg Ser Pro  Arg Thr Ala 
    1175                 1180                 1185             


Glu Gly  Val Leu Ala Ala Arg  Thr Val Ser Ile Ser  Val Gln Ile 
    1190                 1195                 1200             


Ile Arg  Ala Cys Gly Leu Gln  Ala Ala Ala Lys Ala  Leu Ala Glu 
    1205                 1210                 1215             


Arg Glu  Pro Ala Leu Gln Phe  Ser Ala Thr Val Gly  Val Asn Ala 
    1220                 1225                 1230             


Ser Val  Thr Thr His Leu Ser  Phe Leu Pro Gln Gly  Glu Gln Arg 
    1235                 1240                 1245             


Arg Thr  His Pro Val Ala Cys  Ser Phe Cys Pro Glu  Phe Ser His 
    1250                 1255                 1260             


His Val  Glu Phe Thr Cys Asn  Leu Val Thr Gln His  Cys Ser Gly 
    1265                 1270                 1275             


Glu Ala  Cys Phe Leu Ala Glu  Leu Leu Glu Phe Ala  Glu Val Ile 
    1280                 1285                 1290             


Phe Ala  Val Tyr His Glu Asn  Thr Lys Ser Ala Ser  Asp Ile Ile 
    1295                 1300                 1305             


Ser Ile  Glu Ser Cys Lys Glu  Tyr Leu Leu Gly Val  Val Lys Val 
    1310                 1315                 1320             


Pro Thr  Lys Glu Leu Leu Ile  Lys Arg Ser Gly Ile  Thr Gly Trp 
    1325                 1330                 1335             


Tyr Pro  Ile Ile Leu Pro Glu  Asp Gly Gly Leu Pro  His Gly Leu 
    1340                 1345                 1350             


Glu Leu  Met Gln Lys Ile Val  Gly Gly Leu Glu His  Leu Gly Trp 
    1355                 1360                 1365             


Ser Phe  Glu Asn Ser Leu Lys  Asp Phe Val Arg Met  Asp Glu Gly 
    1370                 1375                 1380             


Glu Pro  Ala Thr Val Thr Ile  Ser Thr Pro Arg Leu  Trp Leu Pro 
    1385                 1390                 1395             


Ile His  Cys Val Leu Leu Ala  Gly His Asn His Ile  His Lys Asn 
    1400                 1405                 1410             


Thr Tyr  Cys Tyr Leu Arg Tyr  Lys Phe Tyr Asp His  Glu Ala Phe 
    1415                 1420                 1425             


Trp Thr  Pro Leu Lys Lys Pro  Lys Glu Ser Val Asn  Lys Lys Gln 
    1430                 1435                 1440             


Ile Met  Val Thr Phe Lys Ala  Ser Lys Arg Ala Glu  Val Thr Arg 
    1445                 1450                 1455             


Gly Pro  Ser Leu Leu Trp Tyr  Phe Arg Glu Glu Arg  Leu Glu Ile 
    1460                 1465                 1470             


Gln Val  Trp Arg Ala Tyr Gly  Asn Asp Ser Val Glu  Arg Pro His 
    1475                 1480                 1485             


Gln Thr  Asp Ser Trp Ile Gly  Ser Ala Tyr Val Asp  Leu Ala Arg 
    1490                 1495                 1500             


Leu Gly  Glu Arg Ser Ala Arg  Thr Leu Thr Val Ser  Gly Val Tyr 
    1505                 1510                 1515             


Pro Leu  Phe Gly Arg Asn Ala  Ser Asn Leu Ser Gly  Ala Ala Leu 
    1520                 1525                 1530             


Arg Val  His Val Val Leu Ser  Ser Leu Ser Ser His  Leu Glu Pro 
    1535                 1540                 1545             


Thr His  Glu Leu Asp Ser Met  Asp Cys Ser Ser His  Ser Glu Ser 
    1550                 1555                 1560             


Glu Gln  Leu Pro Arg Arg Asn  Asp Glu Val Gln Leu  Ser Pro Pro 
    1565                 1570                 1575             


Glu Val  Ile Ser Cys His Gln  Lys Ser Pro Ala Ser  Thr Gln Val 
    1580                 1585                 1590             


Pro Cys  Ser Ser Thr Thr Ala  Glu Val Arg Leu Thr  Gln Glu Gly 
    1595                 1600                 1605             


Pro Ala  Asp Leu Asp Gly Thr  Phe Ala Val Ser Ile  Leu Val Glu 
    1610                 1615                 1620             


Arg Ala  Met His Leu Ser Leu  Lys Gly Ser Pro Leu  Thr Glu Arg 
    1625                 1630                 1635             


Lys Val  Ser Ile Pro Ser Cys  Cys Val Ser Phe Ala  Thr Ala Asp 
    1640                 1645                 1650             


Glu Ser  Ser Pro Val Tyr Thr  Gln Val Val Glu Asn  Thr Asp Ser 
    1655                 1660                 1665             


Pro Ile  Trp Asn Phe Gln Gln  Gln Ser Arg Leu Ser  Lys Glu Leu 
    1670                 1675                 1680             


Leu Leu  Asp Pro Gln Gln Thr  Leu Val Phe Lys Val  Trp His Lys 
    1685                 1690                 1695             


Gly Asp  Glu Glu Arg Val Ile  Gly Phe Ala Ser Val  Asp Leu Ser 
    1700                 1705                 1710             


Pro Leu  Leu Ser Gly Phe Gln  Phe Val Cys Gly Trp  Tyr Asn Ile 
    1715                 1720                 1725             


Thr Asp  Phe Ser Gly Glu Cys  Gln Gly Gln Ile Lys  Val Ala Val 
    1730                 1735                 1740             


Ser Pro  Leu Glu Ser Leu Ile  His Phe Lys Glu Glu  Arg Gln Ala 
    1745                 1750                 1755             


Arg Arg  Gly Val Glu Thr Ser  Lys Ser Leu Ile Pro  Ile Tyr Ser 
    1760                 1765                 1770             


Pro Phe  Ser Phe Pro Ala Ser  Asp Thr Tyr Ala Ala  Phe Ser Ser 
    1775                 1780                 1785             


His Met  Ala Arg Gln Thr Leu  Asp Gln Leu Ala His  Ala Ser Ser 
    1790                 1795                 1800             


Lys Glu  Leu Asp Phe Ser Ser  Pro Gly Arg Ser Asp  Thr Thr Arg 
    1805                 1810                 1815             


Ser Gln  Ala Ser Arg His Glu  Glu His Val Gln Asn  Ile Arg Arg 
    1820                 1825                 1830             


Phe His  Glu Ser Leu His Leu  Gln Gly Glu Ala Pro  Leu Pro Cys 
    1835                 1840                 1845             


Asp Asp  Lys Leu Thr Thr Ser  Pro Leu Ser Ser Gln  Thr 
    1850                 1855                 1860     


<210> 5354
<211> 376
<212> PRT
<213> Homo sapiens

<400> 5354
Met Leu Thr Phe Leu Gln Gln Leu Arg Val Asp Trp Pro Ala Ala Ser 
1               5                   10                  15      


Glu Arg Ala Ser Ser His Thr Leu Arg Ser His Ala Leu Glu Glu Leu 
            20                  25                  30          


Thr Ser Ala Asn Asp Gly Arg Thr Leu Ser Pro Gly Ile Leu Gly Arg 
        35                  40                  45              


Leu Cys Leu Lys Glu Leu Val Glu Glu Gln Gly Arg Thr Ala Gly Tyr 
    50                  55                  60                  


Asp Pro Asn Leu Asp Asn Cys Leu Val Thr Glu Asp Leu Leu Ser Val 
65                  70                  75                  80  


Leu Ala Glu Leu Gln Glu Ala Leu Trp His Trp Pro Glu Asp Ser His 
                85                  90                  95      


Pro Gly Leu Ala Gly Ala Ser Asp Thr Gly Thr Gly Gly Cys Leu Val 
            100                 105                 110         


Val His Val Val Ser Cys Glu Glu Glu Phe Gln Gln Gln Lys Leu Asp 
        115                 120                 125             


Leu Leu Trp Gln Lys Leu Val Asp Lys Ala Pro Leu Arg Gln Lys His 
    130                 135                 140                 


Leu Ile Cys Gly Pro Val Lys Val Ala Gly Ala Pro Gly Thr Leu Met 
145                 150                 155                 160 


Thr Ala Pro Glu Tyr Tyr Glu Phe Arg His Thr Gln Val Cys Lys Ala 
                165                 170                 175     


Ser Ala Leu Lys His Gly Gly Asp Leu Ala Gln Asp Pro Ala Trp Thr 
            180                 185                 190         


Glu Ile Phe Gly Val Leu Ser Val Ala Thr Ile Lys Phe Glu Met Leu 
        195                 200                 205             


Ser Thr Ala Pro Gln Ser Gln Leu Phe Leu Ala Leu Ala Asp Ser Ser 
    210                 215                 220                 


Ile Ser Thr Lys Gly Thr Lys Ser Gly Thr Phe Val Met Tyr Asn Cys 
225                 230                 235                 240 


Ala Arg Leu Ala Thr Leu Phe Glu Ser Tyr Lys Cys Ser Met Glu Gln 
                245                 250                 255     


Gly Leu Tyr Pro Thr Phe Pro Pro Val Ser Ser Leu Asp Phe Ser Leu 
            260                 265                 270         


Leu His Asp Glu Gly Glu Trp Leu Leu Leu Phe Asn Ser Ile Leu Pro 
        275                 280                 285             


Phe Pro Asp Leu Leu Ser Arg Thr Ala Val Leu Asp Cys Thr Ala Pro 
    290                 295                 300                 


Gly Leu His Ile Ala Val Arg Thr Glu Met Ile Cys Lys Phe Leu Val 
305                 310                 315                 320 


Gln Leu Ser Met Asp Phe Ser Ser Tyr Tyr Asn Arg Val His Ile Leu 
                325                 330                 335     


Gly Glu Pro Arg Pro His Leu Phe Gly Gln Met Phe Val Arg Leu Gln 
            340                 345                 350         


Leu Leu Arg Ala Val Arg Glu Val Leu His Thr Gly Leu Ala Met Leu 
        355                 360                 365             


Gly Leu Pro Pro Leu Ser His Ile 
    370                 375     


<210> 5355
<211> 523
<212> PRT
<213> Homo sapiens

<400> 5355
Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Leu Phe Val Asp Lys Asp 
        435                 440                 445             


Thr Ile Val Asn Ala Val Gly Ala Ser His Asp Ile His Leu Leu Lys 
    450                 455                 460                 


Ile Asp Asn Arg Glu Asp Glu Leu Val Thr Arg Ile Asn Ser Trp Cys 
465                 470                 475                 480 


Thr Arg Leu Ile Asp Arg Ile His Lys Asp Glu Ile Met Arg Asn Arg 
                485                 490                 495     


Lys Arg Val Lys Glu Ile Asn Gln Tyr Ile Asp His Met Gln Ser Glu 
            500                 505                 510         


Leu Asp Asn Leu Glu Cys Gly Asp Ile Leu Asp 
        515                 520             


<210> 5356
<211> 559
<212> PRT
<213> Homo sapiens

<400> 5356
Met Lys Val Ile Thr Cys Glu Ile Ala Trp His Asn Lys Glu Pro Val 
1               5                   10                  15      


Tyr Ser Leu Asp Phe Gln His Gly Thr Ala Gly Arg Ile His Arg Leu 
            20                  25                  30          


Ala Ser Ala Gly Val Asp Thr Asn Val Arg Ile Trp Lys Val Glu Lys 
        35                  40                  45              


Gly Pro Asp Gly Lys Ala Ile Val Glu Phe Leu Ser Asn Leu Ala Arg 
    50                  55                  60                  


His Thr Lys Ala Val Asn Val Val Arg Phe Ser Pro Thr Gly Glu Ile 
65                  70                  75                  80  


Leu Ala Ser Gly Gly Asp Asp Ala Val Ile Leu Leu Trp Lys Val Asn 
                85                  90                  95      


Asp Asn Lys Glu Pro Glu Gln Ile Ala Phe Gln Asp Glu Asp Glu Ala 
            100                 105                 110         


Gln Leu Asn Lys Glu Asn Trp Thr Val Val Lys Thr Leu Arg Gly His 
        115                 120                 125             


Leu Glu Asp Val Tyr Asp Ile Cys Trp Ala Thr Asp Gly Asn Leu Met 
    130                 135                 140                 


Ala Ser Ala Ser Val Asp Asn Thr Ala Ile Ile Trp Asp Val Ser Lys 
145                 150                 155                 160 


Gly Gln Lys Ile Ser Ile Phe Asn Glu His Lys Ser Tyr Val Gln Gly 
                165                 170                 175     


Val Thr Trp Asp Pro Leu Gly Gln Tyr Val Ala Thr Leu Ser Cys Asp 
            180                 185                 190         


Arg Val Leu Arg Val Tyr Ser Ile Gln Lys Lys Arg Val Ala Phe Asn 
        195                 200                 205             


Val Ser Lys Met Leu Ser Gly Ile Gly Ala Glu Gly Glu Ala Arg Ser 
    210                 215                 220                 


Tyr Arg Met Phe His Asp Asp Ser Met Lys Ser Phe Phe Arg Arg Leu 
225                 230                 235                 240 


Ser Phe Thr Pro Asp Gly Ser Leu Leu Leu Thr Pro Ala Gly Cys Val 
                245                 250                 255     


Glu Ser Gly Glu Asn Val Met Asn Thr Thr Tyr Val Phe Ser Arg Lys 
            260                 265                 270         


Asn Leu Lys Arg Pro Ile Ala His Leu Pro Cys Pro Gly Lys Ala Thr 
        275                 280                 285             


Leu Ala Val Arg Cys Cys Pro Val Tyr Phe Glu Leu Arg Pro Val Val 
    290                 295                 300                 


Glu Thr Gly Val Glu Leu Met Ser Leu Pro Tyr Arg Leu Val Phe Ala 
305                 310                 315                 320 


Val Ala Ser Glu Asp Ser Val Leu Leu Tyr Asp Thr Gln Gln Ser Phe 
                325                 330                 335     


Pro Phe Gly Tyr Val Ser Asn Ile His Tyr His Thr Leu Ser Asp Ile 
            340                 345                 350         


Ser Trp Ser Ser Asp Gly Ala Phe Leu Ala Ile Ser Ser Thr Asp Gly 
        355                 360                 365             


Tyr Cys Ser Phe Val Thr Phe Glu Lys Asp Glu Leu Gly Ile Pro Leu 
    370                 375                 380                 


Lys Glu Lys Pro Val Leu Asn Met Arg Thr Pro Asp Thr Ala Lys Lys 
385                 390                 395                 400 


Thr Lys Ser Gln Thr His Arg Gly Ser Ser Pro Gly Pro Arg Pro Val 
                405                 410                 415     


Glu Gly Thr Pro Ala Ser Arg Thr Gln Asp Pro Ser Ser Pro Gly Thr 
            420                 425                 430         


Thr Pro Pro Gln Ala Arg Gln Ala Pro Ala Pro Thr Val Ile Arg Asp 
        435                 440                 445             


Pro Pro Ser Ile Thr Pro Ala Val Lys Ser Pro Leu Pro Gly Pro Ser 
    450                 455                 460                 


Glu Glu Lys Thr Leu Gln Pro Ser Ser Gln Asn Thr Lys Ala His Pro 
465                 470                 475                 480 


Ser Arg Arg Val Thr Leu Asn Thr Leu Gln Ala Trp Ser Lys Thr Thr 
                485                 490                 495     


Pro Arg Arg Ile Asn Leu Thr Pro Leu Lys Thr Asp Thr Pro Pro Ser 
            500                 505                 510         


Ser Val Pro Thr Ser Val Ile Ser Thr Pro Ser Thr Glu Glu Ile Gln 
        515                 520                 525             


Ser Glu Thr Pro Gly Asp Ala Gln Gly Ser Pro Pro Glu Leu Lys Arg 
    530                 535                 540                 


Pro Arg Leu Asp Glu Asn Lys Gly Gly Thr Glu Ser Leu Asp Pro 
545                 550                 555                 


<210> 5357
<211> 508
<212> PRT
<213> Homo sapiens

<400> 5357
Met Ala Asp Gly Gln Val Ala Glu Leu Leu Leu Arg Arg Leu Glu Ala 
1               5                   10                  15      


Ser Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Ala Glu Leu Gly Met 
            20                  25                  30          


Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly 
        35                  40                  45              


Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys His Trp Glu Leu Thr 
    50                  55                  60                  


Ala Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val 
65                  70                  75                  80  


Phe Arg Ser Ile Pro Pro Glu Gly Leu Ala Gln Ser Glu Leu Met Arg 
                85                  90                  95      


Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp 
            100                 105                 110         


Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val 
        115                 120                 125             


Val Asp Ser Met Glu Asp Glu Val Gln Arg Arg Leu Gln Leu Val Arg 
    130                 135                 140                 


Gly Gly Gln Ala Glu Lys Leu Gly Glu Lys Glu Arg Ser Glu Leu Arg 
145                 150                 155                 160 


Lys Arg Lys Leu Leu Ala Glu Val Thr Leu Lys Thr Tyr Trp Val Ser 
                165                 170                 175     


Lys Gly Ser Ala Phe Ser Thr Ser Ile Ser Lys Gln Glu Thr Glu Leu 
            180                 185                 190         


Ser Pro Glu Met Ile Ser Ser Gly Ser Trp Arg Asp Arg Pro Phe Lys 
        195                 200                 205             


Pro Tyr Asn Phe Leu Ala His Gly Val Leu Pro Asp Ser Gly His Leu 
    210                 215                 220                 


His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu Glu 
225                 230                 235                 240 


Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser Phe 
                245                 250                 255     


Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg Asp 
            260                 265                 270         


Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln Leu 
        275                 280                 285             


Pro Met Asp Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Tyr Lys Tyr Asn Trp Lys Leu Asp Glu Ala Arg 
305                 310                 315                 320 


Lys Asn Leu Leu Arg Thr His Thr Thr Ser Ala Ser Ala Arg Ala Leu 
                325                 330                 335     


Tyr Arg Leu Ala Gln Lys Lys Pro Phe Thr Pro Val Lys Tyr Phe Ser 
            340                 345                 350         


Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu Ala 
        355                 360                 365             


Glu Phe His Gln Ile Glu Gly Val Val Ala Asp His Gly Leu Thr Leu 
    370                 375                 380                 


Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly Ile 
385                 390                 395                 400 


Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Thr Glu Pro Ser 
                405                 410                 415     


Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu Val 
            420                 425                 430         


Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly Leu 
        435                 440                 445             


Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg Pro 
    450                 455                 460                 


Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly His 
465                 470                 475                 480 


Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Leu Cys Arg Leu Asp 
                485                 490                 495     


Ala Glu Pro Arg Pro Pro Pro Thr Gln Glu Ala Ala 
            500                 505             


<210> 5358
<211> 400
<212> PRT
<213> Homo sapiens

<400> 5358
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Gly Asp Ser Leu Ala Pro Pro Glu Val Asp Phe Asp Arg Leu 
65                  70                  75                  80  


Leu Ala Ser Leu Gln Asp Leu Ser Glu Leu Val Val Glu Gly Asp Thr 
                85                  90                  95      


Gln Val Thr Pro Val Pro Gly Gly Ala Arg Leu Arg Thr Leu Glu Pro 
            100                 105                 110         


Ile Pro Leu Lys Leu Tyr Arg Asn Gly Ile Met Met Phe Asp Gly Pro 
        115                 120                 125             


Phe Gln Pro Phe Tyr Asp Pro Ser Thr Gln Arg Cys Leu Arg Asp Ile 
    130                 135                 140                 


Leu Asp Gly Phe Phe Pro Ser Glu Leu Gln Arg Leu Tyr Pro Asn Gly 
145                 150                 155                 160 


Val Pro Phe Lys Val Ser Asp Leu Arg Asn Gln Val Tyr Leu Glu Asp 
                165                 170                 175     


Gly Leu Asp Pro Phe Pro Gly Glu Gly Arg Val Val Gly Arg Gln Leu 
            180                 185                 190         


Met His Lys Ala Leu Asp Arg Val Glu Glu His Pro Gly Ser Arg Met 
        195                 200                 205             


Thr Ala Glu Lys Phe Leu Asn Arg Leu Pro Lys Phe Val Ile Arg Gln 
    210                 215                 220                 


Gly Glu Val Ile Asp Ile Arg Gly Pro Ile Arg Asp Thr Leu Gln Asn 
225                 230                 235                 240 


Cys Cys Pro Leu Pro Ala Arg Ile Gln Glu Ile Val Val Glu Thr Pro 
                245                 250                 255     


Thr Leu Ala Ala Glu Arg Glu Arg Ser Gln Glu Ser Pro Asn Thr Pro 
            260                 265                 270         


Ala Pro Pro Leu Ser Met Leu Arg Ile Lys Ser Glu Asn Gly Glu Gln 
        275                 280                 285             


Ala Phe Leu Leu Met Met Gln Pro Asp Asn Thr Ile Gly Asp Val Arg 
    290                 295                 300                 


Ala Leu Leu Ala Gln Ala Arg Val Met Asp Ala Ser Ala Phe Glu Ile 
305                 310                 315                 320 


Phe Ser Thr Phe Pro Pro Thr Leu Tyr Gln Asp Asp Thr Leu Thr Leu 
                325                 330                 335     


Gln Ala Ala Gly Leu Val Pro Lys Ala Ala Leu Leu Leu Arg Ala Arg 
            340                 345                 350         


Arg Ala Pro Lys Ser Ser Leu Lys Phe Ser Pro Gly Pro Cys Pro Gly 
        355                 360                 365             


Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
    370                 375                 380                 


Pro Gly Pro Gly Pro Ser Pro Cys Pro Gly Pro Ser Pro Ser Pro Gln 
385                 390                 395                 400 


<210> 5359
<211> 449
<212> PRT
<213> Homo sapiens

<400> 5359
Met Ala Ser Ala Leu Arg Pro Pro Arg Val Pro Lys Pro Lys Gly Val 
1               5                   10                  15      


Leu Pro Ser His Tyr Tyr Glu Ser Phe Leu Glu Lys Lys Gly Pro Cys 
            20                  25                  30          


Asp Arg Asp Tyr Lys Lys Phe Trp Ala Gly Leu Gln Gly Leu Thr Ile 
        35                  40                  45              


Tyr Phe Tyr Asn Ser Asn Arg Asp Phe Gln His Val Glu Lys Leu Asn 
    50                  55                  60                  


Leu Gly Ala Phe Glu Lys Leu Thr Asp Glu Ile Pro Trp Gly Ser Ser 
65                  70                  75                  80  


Arg Asp Pro Gly Thr His Phe Ser Leu Ile Leu Arg Asp Gln Glu Ile 
                85                  90                  95      


Lys Phe Lys Val Glu Thr Leu Glu Cys Arg Glu Met Trp Lys Gly Phe 
            100                 105                 110         


Ile Leu Thr Val Val Glu Leu Arg Val Pro Thr Asp Leu Thr Leu Leu 
        115                 120                 125             


Pro Gly His Leu Tyr Met Met Ser Glu Val Leu Ala Lys Glu Glu Ala 
    130                 135                 140                 


Arg Arg Ala Leu Glu Thr Pro Ser Cys Phe Leu Lys Val Ser Arg Leu 
145                 150                 155                 160 


Glu Ala Gln Leu Leu Leu Glu Arg Tyr Pro Glu Cys Gly Asn Leu Leu 
                165                 170                 175     


Leu Arg Pro Ser Gly Asp Gly Ala Asp Gly Val Ser Val Thr Thr Arg 
            180                 185                 190         


Gln Met His Asn Gly Thr His Val Val Arg His Tyr Lys Val Lys Arg 
        195                 200                 205             


Glu Gly Pro Lys Tyr Val Ile Asp Val Glu Gln Pro Phe Ser Cys Thr 
    210                 215                 220                 


Ser Leu Asp Ala Val Val Asn Tyr Phe Val Ser His Thr Lys Lys Ala 
225                 230                 235                 240 


Leu Val Pro Phe Leu Leu Asp Glu Asp Tyr Glu Lys Val Leu Gly Tyr 
                245                 250                 255     


Val Glu Ala Asp Lys Glu Asn Gly Glu Asn Val Trp Val Ala Pro Ser 
            260                 265                 270         


Ala Pro Gly Pro Gly Pro Ala Pro Cys Thr Gly Gly Pro Lys Pro Leu 
        275                 280                 285             


Ser Pro Ala Ser Ser Gln Asp Lys Leu Pro Pro Leu Pro Pro Leu Pro 
    290                 295                 300                 


Asn Gln Glu Glu Asn Tyr Val Thr Pro Ile Gly Asp Gly Pro Ala Val 
305                 310                 315                 320 


Asp Tyr Glu Asn Gln Asp Val Ala Ser Ser Ser Trp Pro Val Ile Leu 
                325                 330                 335     


Lys Pro Lys Lys Leu Pro Lys Pro Pro Ala Lys Leu Pro Lys Pro Pro 
            340                 345                 350         


Val Gly Pro Lys Pro Val Glu Lys Gly Phe His His Val Ala Gln Ala 
        355                 360                 365             


Gly Leu Glu Leu Leu Thr Ser Ser Asp Pro Pro Thr Ser Ala Ser Gln 
    370                 375                 380                 


Ser Ala Gly Ile Thr Gly Val Ser His His Thr Trp Pro His Leu Ser 
385                 390                 395                 400 


Ser Leu Pro Glu Pro Lys Val Phe Asn Gly Gly Leu Gly Arg Lys Leu 
                405                 410                 415     


Pro Val Ser Ser Ala Gln Pro Leu Phe Pro Thr Ala Gly Leu Ala Asp 
            420                 425                 430         


Met Thr Ala Glu Leu Gln Lys Lys Leu Glu Lys Arg Arg Ala Leu Glu 
        435                 440                 445             


His 
    


<210> 5360
<211> 412
<212> PRT
<213> Homo sapiens

<400> 5360
Met Asp Pro Ile Arg Ser Phe Cys Gly Lys Leu Arg Ser Leu Ala Ser 
1               5                   10                  15      


Thr Leu Asp Cys Glu Thr Ala Arg Leu Gln Arg Ala Leu Asp Gly Glu 
            20                  25                  30          


Glu Ser Asp Phe Glu Asp Tyr Pro Met Arg Ile Leu Tyr Asp Leu His 
        35                  40                  45              


Ser Glu Val Gln Thr Leu Lys Asp Asp Val Asn Ile Leu Leu Asp Lys 
    50                  55                  60                  


Ala Arg Leu Glu Asn Gln Glu Gly Ile Asp Phe Ile Lys Ala Thr Lys 
65                  70                  75                  80  


Val Leu Met Glu Lys Asn Ser Met Asp Ile Met Lys Ile Arg Glu Tyr 
                85                  90                  95      


Phe Gln Lys Tyr Gly Tyr Ser Pro Arg Val Lys Lys Asn Ser Val His 
            100                 105                 110         


Glu Gln Glu Ala Ile Asn Ser Asp Pro Glu Leu Ser Asn Cys Glu Asn 
        115                 120                 125             


Phe Gln Lys Thr Asp Val Lys Asp Asp Leu Ser Asp Pro Pro Val Ala 
    130                 135                 140                 


Ser Ser Cys Ile Ser Glu Lys Ser Pro Arg Ser Pro Gln Leu Ser Asp 
145                 150                 155                 160 


Phe Gly Leu Glu Arg Tyr Ile Val Ser Gln Val Leu Pro Asn Pro Pro 
                165                 170                 175     


Gln Ala Val Asn Asn Tyr Lys Glu Glu Pro Val Ile Val Thr Pro Pro 
            180                 185                 190         


Thr Lys Gln Ser Leu Val Lys Val Leu Lys Thr Pro Lys Cys Ala Leu 
        195                 200                 205             


Lys Met Asp Asp Phe Glu Cys Val Thr Pro Lys Leu Glu His Phe Gly 
    210                 215                 220                 


Ile Ser Glu Tyr Thr Met Cys Leu Asn Glu Asp Tyr Thr Met Gly Leu 
225                 230                 235                 240 


Lys Asn Ala Arg Asn Asn Lys Ser Glu Glu Ala Ile Asp Thr Glu Ser 
                245                 250                 255     


Arg Leu Asn Asp Asn Val Phe Ala Thr Pro Ser Pro Ile Ile Gln Gln 
            260                 265                 270         


Leu Glu Lys Ser Asp Ala Glu Tyr Thr Asn Ser Pro Leu Val Pro Thr 
        275                 280                 285             


Phe Cys Thr Pro Gly Leu Lys Ile Pro Ser Thr Lys Asn Ser Ile Ala 
    290                 295                 300                 


Leu Val Ser Thr Asn Tyr Pro Leu Ser Lys Thr Asn Ser Ser Ser Asn 
305                 310                 315                 320 


Asp Leu Glu Val Glu Asp Arg Thr Ser Leu Val Leu Asn Ser Asp Thr 
                325                 330                 335     


Cys Phe Glu Asn Leu Thr Asp Pro Ser Ser Pro Thr Ile Ser Ser Tyr 
            340                 345                 350         


Glu Asn Leu Leu Arg Thr Pro Thr Pro Pro Glu Val Thr Lys Ile Pro 
        355                 360                 365             


Glu Asp Ile Leu Gln Leu Leu Ser Lys Tyr Asn Ser Asn Leu Ala Thr 
    370                 375                 380                 


Pro Ile Ala Ile Lys Ala Val Pro Pro Ser Lys Arg Phe Leu Lys His 
385                 390                 395                 400 


Gly Gln Asn Ile Arg Asp Val Ser Asn Lys Glu Asn 
                405                 410         


<210> 5361
<211> 860
<212> PRT
<213> Homo sapiens

<400> 5361
Met Thr Glu Gly Thr Lys Lys Thr Ser Lys Lys Phe Lys Phe Phe Lys 
1               5                   10                  15      


Phe Lys Gly Phe Gly Ser Leu Ser Asn Leu Pro Arg Ser Phe Thr Leu 
            20                  25                  30          


Arg Arg Ser Ser Ala Ser Ile Ser Arg Gln Ser His Leu Glu Pro Asp 
        35                  40                  45              


Thr Phe Glu Ala Thr Gln Asp Asp Met Val Thr Val Pro Lys Ser Pro 
    50                  55                  60                  


Pro Ala Tyr Ala Arg Ser Ser Asp Met Tyr Ser His Met Gly Thr Met 
65                  70                  75                  80  


Pro Arg Pro Ser Ile Lys Lys Ala Gln Asn Ser Gln Ala Ala Arg Gln 
                85                  90                  95      


Ala Gln Glu Ala Gly Pro Lys Pro Asn Leu Val Pro Gly Gly Val Pro 
            100                 105                 110         


Asp Pro Pro Gly Leu Glu Ala Ala Lys Glu Val Met Val Lys Ala Thr 
        115                 120                 125             


Gly Pro Leu Glu Asp Thr Pro Ala Met Glu Pro Asn Pro Ser Ala Val 
    130                 135                 140                 


Glu Val Asp Pro Ile Arg Lys Pro Glu Val Pro Thr Gly Asp Val Glu 
145                 150                 155                 160 


Glu Glu Arg Pro Pro Arg Asp Val His Ser Glu Arg Ala Ala Gly Glu 
                165                 170                 175     


Pro Glu Ala Gly Ser Asp Tyr Val Lys Phe Ser Lys Glu Lys Tyr Ile 
            180                 185                 190         


Leu Asp Ser Ser Pro Glu Lys Leu His Lys Glu Leu Glu Glu Glu Leu 
        195                 200                 205             


Lys Leu Ser Ser Thr Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg 
    210                 215                 220                 


Ile Pro Arg Glu Val Ser Glu Thr Leu Val Gln Arg Asn Gly Asp Phe 
225                 230                 235                 240 


Leu Ile Arg Asp Ser Leu Thr Ser Leu Gly Asp Tyr Val Leu Thr Cys 
                245                 250                 255     


Arg Trp Arg Asn Gln Ala Leu His Phe Lys Ile Asn Lys Val Val Val 
            260                 265                 270         


Lys Ala Gly Glu Ser Tyr Thr His Ile Gln Tyr Leu Phe Glu Gln Glu 
        275                 280                 285             


Ser Phe Asp His Val Pro Ala Leu Val Arg Tyr His Val Gly Ser Arg 
    290                 295                 300                 


Lys Ala Val Ser Glu Gln Ser Gly Ala Ile Ile Tyr Cys Pro Val Asn 
305                 310                 315                 320 


Arg Thr Phe Pro Leu Arg Tyr Leu Glu Ala Ser Tyr Gly Leu Gly Gln 
                325                 330                 335     


Gly Ser Ser Lys Pro Ala Ser Pro Val Ser Pro Ser Gly Pro Lys Gly 
            340                 345                 350         


Ser His Met Lys Arg Arg Ser Val Thr Met Thr Asp Gly Leu Thr Ala 
        355                 360                 365             


Asp Lys Val Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr Ser Leu Pro 
    370                 375                 380                 


Arg Pro Arg Asp Ser Ile Arg Ser Cys Ala Leu Ser Met Asp Gln Ile 
385                 390                 395                 400 


Pro Asp Leu His Ser Pro Met Ser Pro Ile Ser Glu Ser Pro Ser Ser 
                405                 410                 415     


Pro Ala Tyr Ser Thr Val Thr Arg Val His Ala Ala Pro Ala Ala Pro 
            420                 425                 430         


Ser Ala Thr Ala Leu Pro Ala Ser Pro Val Ala Arg Arg Ser Ser Glu 
        435                 440                 445             


Pro Gln Leu Cys Pro Gly Ser Ala Pro Lys Thr His Gly Glu Ser Asp 
    450                 455                 460                 


Lys Gly Pro His Thr Ser Pro Ser His Thr Leu Gly Lys Ala Ser Pro 
465                 470                 475                 480 


Ser Pro Ser Leu Ser Ser Tyr Ser Asp Pro Asp Ser Gly His Tyr Cys 
                485                 490                 495     


Gln Leu Gln Pro Pro Val Arg Gly Ser Arg Glu Trp Ala Ala Thr Glu 
            500                 505                 510         


Thr Ser Ser Gln Gln Ala Arg Ser Tyr Gly Glu Arg Leu Lys Glu Leu 
        515                 520                 525             


Ser Glu Asn Gly Ala Pro Glu Gly Asp Trp Gly Lys Thr Phe Thr Val 
    530                 535                 540                 


Pro Ile Val Glu Val Thr Ser Ser Phe Asn Pro Ala Thr Phe Gln Ser 
545                 550                 555                 560 


Leu Leu Ile Pro Arg Asp Asn Arg Pro Leu Glu Val Gly Leu Leu Arg 
                565                 570                 575     


Lys Val Lys Glu Leu Leu Ala Glu Val Asp Ala Arg Thr Leu Ala Arg 
            580                 585                 590         


His Val Thr Lys Val Asp Cys Leu Val Ala Arg Ile Leu Gly Val Thr 
        595                 600                 605             


Lys Glu Met Gln Thr Leu Met Gly Val Arg Trp Gly Met Glu Leu Leu 
    610                 615                 620                 


Thr Leu Pro His Gly Arg Gln Leu Arg Leu Asp Leu Leu Glu Arg Phe 
625                 630                 635                 640 


His Thr Met Ser Ile Met Leu Ala Val Asp Ile Leu Gly Cys Thr Gly 
                645                 650                 655     


Ser Ala Glu Glu Arg Ala Ala Leu Leu His Lys Thr Ile Gln Leu Ala 
            660                 665                 670         


Ala Glu Leu Arg Gly Thr Met Gly Asn Met Phe Ser Phe Ala Ala Val 
        675                 680                 685             


Met Gly Ala Leu Asp Met Ala Gln Ile Ser Arg Leu Glu Gln Thr Trp 
    690                 695                 700                 


Val Thr Leu Arg Gln Arg His Thr Glu Gly Ala Ile Leu Tyr Glu Lys 
705                 710                 715                 720 


Lys Leu Lys Pro Phe Leu Lys Ser Leu Asn Glu Gly Lys Glu Gly Pro 
                725                 730                 735     


Pro Leu Ser Asn Thr Thr Phe Pro His Val Leu Pro Leu Ile Thr Leu 
            740                 745                 750         


Leu Glu Cys Asp Ser Ala Pro Pro Glu Gly Pro Glu Pro Trp Gly Ser 
        755                 760                 765             


Thr Glu His Gly Val Glu Val Val Leu Ala His Leu Glu Ala Ala Arg 
    770                 775                 780                 


Thr Val Ala His His Gly Gly Leu Tyr His Thr Asn Ala Glu Val Lys 
785                 790                 795                 800 


Leu Gln Gly Phe Gln Ala Arg Pro Glu Leu Leu Glu Val Phe Ser Thr 
                805                 810                 815     


Glu Phe Gln Met Arg Leu Leu Trp Gly Ser Gln Gly Ala Ser Ser Ser 
            820                 825                 830         


Gln Ala Arg Arg Tyr Glu Lys Phe Asp Lys Val Leu Thr Ala Leu Ser 
        835                 840                 845             


His Lys Leu Glu Pro Ala Val Arg Ser Ser Glu Leu 
    850                 855                 860 


<210> 5362
<211> 190
<212> PRT
<213> Homo sapiens

<400> 5362
Met Thr Val Pro Trp Arg Pro Gly Lys Arg Arg Ile Thr Tyr Lys Glu 
1               5                   10                  15      


Glu Glu Asp Leu Thr Leu Gln Pro Arg Pro Ala Ser Ser Ala Pro Glu 
            20                  25                  30          


Ser Leu Val Gly Leu Gln Glu Gly Lys Ser Thr Glu Gln Gly Asn His 
        35                  40                  45              


Asp Gln Leu Lys Glu Leu Tyr Ser Ala Gly Asn Leu Thr Val Leu Ala 
    50                  55                  60                  


Thr Asp Pro Leu Leu His Gln Asp Pro Val Gln Leu Asp Phe His Phe 
65                  70                  75                  80  


Arg Leu Thr Ser Gln Thr Ser Ala His Trp His Gly Leu Leu Cys Asp 
                85                  90                  95      


Arg Arg Leu Phe Leu Asp Ile Pro Tyr Gln Ala Leu Asp Gln Gly Asn 
            100                 105                 110         


Arg Glu Ser Leu Thr Ala Thr Leu Glu Tyr Val Glu Glu Lys Thr Asn 
        115                 120                 125             


Val Asp Ser Val Phe Val Asn Phe Gln Asn Asp Arg Asn Asp Arg Gly 
    130                 135                 140                 


Ala Leu Leu Arg Ala Phe Ser Tyr Met Gly Phe Glu Val Val Arg Pro 
145                 150                 155                 160 


Asp His Pro Ala Leu Pro Pro Leu Asp Asn Val Ile Phe Met Val Tyr 
                165                 170                 175     


Pro Leu Glu Arg Asp Val Gly His Leu Pro Ser Glu Pro Pro 
            180                 185                 190 


<210> 5363
<211> 508
<212> PRT
<213> Homo sapiens

<400> 5363
Met Ala Thr Asp Trp Leu Gly Ser Ile Val Ser Ile Asn Cys Gly Asp 
1               5                   10                  15      


Ser Leu Gly Val Tyr Gln Gly Arg Val Ser Ala Val Asp Gln Val Ser 
            20                  25                  30          


Gln Thr Ile Ser Leu Thr Arg Pro Phe His Asn Gly Val Lys Cys Leu 
        35                  40                  45              


Val Pro Glu Val Thr Phe Arg Ala Gly Asp Ile Thr Glu Leu Lys Ile 
    50                  55                  60                  


Leu Glu Ile Pro Gly Pro Gly Asp Asn Gln His Phe Gly Asp Leu His 
65                  70                  75                  80  


Gln Thr Glu Leu Gly Pro Ser Gly Ala Gly Cys Gln Val Gly Ile Asn 
                85                  90                  95      


Gln Asn Gly Thr Gly Lys Phe Val Lys Lys Pro Ala Ser Ser Ser Ser 
            100                 105                 110         


Ala Pro Gln Asn Ile Pro Lys Arg Thr Asp Val Lys Ser Gln Asp Val 
        115                 120                 125             


Ala Val Ser Pro Gln Gln Gln Gln Cys Ser Lys Ser Tyr Val Asp Arg 
    130                 135                 140                 


His Met Glu Ser Leu Ser Gln Ser Lys Ser Phe Arg Arg Arg His Asn 
145                 150                 155                 160 


Ser Trp Ser Ser Ser Ser Arg His Pro Asn Gln Ala Thr Pro Lys Lys 
                165                 170                 175     


Ser Gly Leu Lys Asn Gly Gln Met Lys Asn Lys Asp Asp Glu Cys Phe 
            180                 185                 190         


Gly Asp Asp Ile Glu Glu Ile Pro Asp Thr Asp Phe Asp Phe Glu Gly 
        195                 200                 205             


Asn Leu Ala Leu Phe Asp Lys Ala Ala Val Phe Glu Glu Ile Asp Thr 
    210                 215                 220                 


Tyr Glu Arg Arg Ser Gly Thr Arg Ser Arg Gly Ile Pro Asn Glu Arg 
225                 230                 235                 240 


Pro Thr Arg Tyr Arg His Asp Glu Asn Ile Leu Glu Ser Glu Pro Ile 
                245                 250                 255     


Val Tyr Arg Arg Ile Ile Val Pro His Asn Val Ser Lys Glu Phe Cys 
            260                 265                 270         


Thr Asp Ser Gly Leu Val Val Pro Ser Ile Ser Tyr Glu Leu His Lys 
        275                 280                 285             


Lys Leu Leu Ser Val Ala Glu Lys His Gly Leu Thr Leu Glu Arg Arg 
    290                 295                 300                 


Leu Glu Met Thr Gly Val Cys Ala Ser Gln Met Ala Leu Thr Leu Leu 
305                 310                 315                 320 


Gly Gly Pro Asn Arg Leu Asn Pro Lys Asn Val His Gln Arg Pro Thr 
                325                 330                 335     


Val Ala Leu Leu Cys Gly Pro His Val Lys Gly Ala Gln Gly Ile Ser 
            340                 345                 350         


Cys Gly Arg His Leu Ala Asn His Asp Val Gln Val Ile Leu Phe Leu 
        355                 360                 365             


Pro Asn Phe Val Lys Met Leu Glu Ser Ile Thr Asn Glu Leu Ser Leu 
    370                 375                 380                 


Phe Ser Lys Thr Gln Gly Gln Gln Val Ser Ser Leu Lys Asp Leu Pro 
385                 390                 395                 400 


Thr Ser Pro Val Asp Leu Val Ile Asn Cys Leu Asp Cys Pro Glu Asn 
                405                 410                 415     


Val Phe Leu Arg Asp Gln Pro Trp Tyr Lys Ala Ala Val Ala Trp Ala 
            420                 425                 430         


Asn Gln Asn Arg Ala Pro Val Leu Ser Ile Asp Pro Pro Val His Glu 
        435                 440                 445             


Val Glu Gln Gly Ile Asp Ala Lys Trp Ser Leu Ala Leu Gly Leu Pro 
    450                 455                 460                 


Leu Pro Leu Gly Glu His Ala Gly Arg Ile Tyr Leu Cys Asp Ile Gly 
465                 470                 475                 480 


Ile Pro Gln Gln Val Phe Gln Glu Val Gly Ile Asn Tyr His Ser Pro 
                485                 490                 495     


Phe Gly Cys Lys Phe Val Ile Pro Leu His Ser Ala 
            500                 505             


<210> 5364
<211> 385
<212> PRT
<213> Homo sapiens

<400> 5364
Met Gly Arg Trp Cys Gln Thr Val Ala Arg Gly Gln Arg Pro Arg Thr 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ala Gly Ala Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Arg Ser Ala Gly Cys Trp Gly Ala Gly Glu Ala Pro Gly Ala Leu Ser 
        35                  40                  45              


Thr Ala Asp Pro Ala Asp Gln Ser Val Gln Cys Val Pro Lys Ala Thr 
    50                  55                  60                  


Cys Pro Ser Ser Arg Pro Arg Leu Leu Trp Gln Thr Pro Thr Thr Gln 
65                  70                  75                  80  


Thr Leu Pro Ser Thr Thr Met Glu Thr Gln Phe Pro Val Ser Glu Gly 
                85                  90                  95      


Lys Val Asp Pro Tyr Arg Ser Cys Gly Phe Ser Tyr Glu Gln Asp Pro 
            100                 105                 110         


Thr Leu Arg Asp Pro Glu Ala Val Ala Arg Arg Trp Pro Trp Met Val 
        115                 120                 125             


Ser Val Arg Ala Asn Gly Thr His Ile Cys Ala Gly Thr Ile Ile Ala 
    130                 135                 140                 


Ser Gln Trp Val Leu Thr Val Ala His Cys Leu Ile Trp Arg Asp Val 
145                 150                 155                 160 


Ile Tyr Ser Val Arg Val Gly Ser Pro Trp Ile Asp Gln Met Thr Gln 
                165                 170                 175     


Thr Ala Ser Asp Val Pro Val Leu Gln Val Ile Met His Ser Arg Tyr 
            180                 185                 190         


Arg Ala Gln Arg Phe Trp Ser Trp Val Gly Gln Ala Asn Asp Ile Gly 
        195                 200                 205             


Leu Leu Lys Leu Lys Gln Glu Leu Lys Tyr Ser Asn Tyr Val Arg Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Thr Asp Tyr Val Leu Lys Asp His Ser Arg Cys 
225                 230                 235                 240 


Thr Val Thr Gly Trp Gly Leu Ser Lys Ala Asp Gly Met Trp Pro Gln 
                245                 250                 255     


Phe Arg Thr Ile Gln Glu Lys Glu Val Ile Ile Leu Asn Asn Lys Glu 
            260                 265                 270         


Cys Asp Asn Phe Tyr His Asn Phe Thr Lys Ile Pro Thr Leu Val Gln 
        275                 280                 285             


Ile Ile Lys Ser Gln Met Met Cys Ala Glu Asp Thr His Arg Glu Lys 
    290                 295                 300                 


Phe Cys Tyr Glu Leu Thr Gly Glu Pro Leu Val Cys Ser Met Glu Gly 
305                 310                 315                 320 


Thr Trp Tyr Leu Val Gly Leu Val Ser Trp Gly Ala Gly Cys Gln Lys 
                325                 330                 335     


Ser Glu Ala Pro Pro Ile Tyr Leu Gln Val Ser Ser Tyr Gln His Trp 
            340                 345                 350         


Ile Trp Asp Cys Leu Asn Gly Gln Ala Leu Ala Leu Pro Ala Pro Ser 
        355                 360                 365             


Arg Thr Leu Leu Leu Ala Leu Pro Leu Pro Leu Ser Leu Leu Ala Ala 
    370                 375                 380                 


Leu 
385 


<210> 5365
<211> 249
<212> PRT
<213> Homo sapiens

<400> 5365
Met Val Asp Arg Leu Ala Asn Ser Glu Ala Asn Thr Arg Arg Ile Ser 
1               5                   10                  15      


Ile Val Glu Asn Cys Phe Gly Ala Ala Gly Gln Pro Leu Thr Ile Pro 
            20                  25                  30          


Gly Arg Val Leu Ile Gly Glu Gly Val Leu Thr Lys Leu Cys Arg Lys 
        35                  40                  45              


Lys Pro Lys Ala Arg Gln Phe Phe Leu Phe Asn Asp Ile Leu Val Tyr 
    50                  55                  60                  


Gly Asn Ile Val Ile Gln Lys Lys Lys Tyr Asn Lys Gln His Ile Ile 
65                  70                  75                  80  


Pro Leu Glu Asn Val Thr Ile Asp Ser Ile Lys Asp Glu Gly Asp Leu 
                85                  90                  95      


Arg Asn Gly Trp Leu Ile Lys Thr Pro Thr Lys Ser Phe Ala Val Tyr 
            100                 105                 110         


Ala Ala Thr Ala Thr Glu Lys Ser Glu Trp Met Asn His Ile Asn Lys 
        115                 120                 125             


Cys Val Thr Asp Leu Leu Ser Lys Ser Gly Lys Thr Pro Ser Asn Glu 
    130                 135                 140                 


His Ala Ala Val Trp Val Pro Asp Ser Glu Ala Thr Val Cys Met Arg 
145                 150                 155                 160 


Cys Gln Lys Ala Lys Phe Thr Pro Val Asn Arg Arg His His Cys Arg 
                165                 170                 175     


Lys Cys Gly Phe Val Val Cys Gly Pro Cys Ser Glu Lys Arg Phe Leu 
            180                 185                 190         


Leu Pro Ser Gln Ser Ser Lys Pro Val Arg Ile Cys Asp Phe Cys Tyr 
        195                 200                 205             


Asp Leu Leu Ser Ala Gly Asp Met Ala Thr Cys Gln Pro Ala Arg Ser 
    210                 215                 220                 


Asp Ser Tyr Ser Gln Ser Leu Lys Ser Pro Leu Asn Asp Met Ser Asp 
225                 230                 235                 240 


Asp Asp Asp Asp Asp Asp Ser Ser Asp 
                245                 


<210> 5366
<211> 914
<212> PRT
<213> Homo sapiens

<400> 5366
Met Gly Asp Ser Arg Asp Leu Cys Pro His Leu Asp Ser Ile Gly Glu 
1               5                   10                  15      


Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Gly Thr Cys Gln Ser 
            20                  25                  30          


Cys Gly Val Thr Gly Pro Asn Leu Trp Ala Cys Leu Gln Val Ala Cys 
        35                  40                  45              


Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His 
    50                  55                  60                  


Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg 
65                  70                  75                  80  


Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu 
                85                  90                  95      


Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser 
            100                 105                 110         


Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp 
        115                 120                 125             


Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu 
    130                 135                 140                 


Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu 
145                 150                 155                 160 


Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe Phe Leu Glu Cys 
                165                 170                 175     


Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr 
            180                 185                 190         


Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val 
        195                 200                 205             


Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe 
    210                 215                 220                 


Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met 
225                 230                 235                 240 


Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala 
                245                 250                 255     


Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg 
            260                 265                 270         


Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser 
        275                 280                 285             


Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser 
    290                 295                 300                 


Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala 
305                 310                 315                 320 


Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln 
                325                 330                 335     


Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr 
            340                 345                 350         


Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser 
        355                 360                 365             


Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala 
    370                 375                 380                 


His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu 
385                 390                 395                 400 


Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg 
                405                 410                 415     


Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly 
            420                 425                 430         


Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile 
        435                 440                 445             


Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg 
    450                 455                 460                 


Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro 
465                 470                 475                 480 


Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val 
                485                 490                 495     


Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp 
            500                 505                 510         


Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr 
        515                 520                 525             


Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala 
    530                 535                 540                 


Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys 
545                 550                 555                 560 


Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu 
                565                 570                 575     


Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu 
            580                 585                 590         


Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu 
        595                 600                 605             


Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile 
    610                 615                 620                 


Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly 
625                 630                 635                 640 


Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp 
                645                 650                 655     


Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val 
            660                 665                 670         


Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu 
        675                 680                 685             


Ala Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu 
    690                 695                 700                 


Pro Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe 
705                 710                 715                 720 


Asn Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys 
                725                 730                 735     


Ser His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu 
            740                 745                 750         


Val Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe 
        755                 760                 765             


Gly Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln 
    770                 775                 780                 


Val Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr 
785                 790                 795                 800 


Phe Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val 
                805                 810                 815     


Ile Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val 
            820                 825                 830         


Lys Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile 
        835                 840                 845             


Ala Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp 
    850                 855                 860                 


Tyr Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr 
865                 870                 875                 880 


Gly Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu 
                885                 890                 895     


Gly Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg 
            900                 905                 910         


Ala Val 
        


<210> 5367
<211> 446
<212> PRT
<213> Homo sapiens

<400> 5367
Met Arg Ala Ala Arg Arg Gly Leu His Cys Ala Gly Ala Glu Arg Pro 
1               5                   10                  15      


Arg Arg Arg Gly Arg Leu Trp Asp Ser Ser Gly Val Pro Gln Arg Gln 
            20                  25                  30          


Lys Arg Pro Gly Pro Trp Arg Thr Gln Thr Gln Glu Gln Met Ser Arg 
        35                  40                  45              


Asp Val Cys Ile His Thr Trp Pro Cys Thr Tyr Tyr Leu Glu Pro Lys 
    50                  55                  60                  


Arg Arg Trp Val Thr Gly Gln Leu Ser Leu Thr Ser Leu Ser Leu Arg 
65                  70                  75                  80  


Phe Met Thr Asp Ser Thr Gly Glu Ile Leu Val Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Ile Val Glu Ile Lys Lys Glu Ala Ser His Phe Ile Phe Ser Ser 
            100                 105                 110         


Ile Thr Ile Leu Glu Lys Gly His Ala Lys His Trp Phe Ser Ser Leu 
        115                 120                 125             


Arg Pro Ser Arg Asn Val Val Phe Ser Ile Ile Glu His Phe Trp Arg 
    130                 135                 140                 


Glu Leu Leu Leu Ser Gln Pro Gly Ala Val Ala Asp Ala Ser Val Pro 
145                 150                 155                 160 


Arg Thr Arg Gly Glu Glu Leu Thr Gly Leu Met Ala Gly Ser Gln Lys 
                165                 170                 175     


Arg Leu Glu Asp Thr Ala Arg Val Leu His His Gln Gly Gln Gln Leu 
            180                 185                 190         


Asp Ser Val Met Arg Gly Leu Asp Lys Met Glu Ser Asp Leu Glu Val 
        195                 200                 205             


Ala Asp Arg Leu Leu Thr Glu Leu Glu Ser Pro Ala Trp Trp Pro Phe 
    210                 215                 220                 


Ser Ser Lys Leu Trp Lys Thr Pro Pro Glu Thr Lys Pro Arg Glu Asp 
225                 230                 235                 240 


Val Ser Met Thr Ser Cys Glu Pro Phe Gly Lys Glu Gly Ile Leu Ile 
                245                 250                 255     


Lys Ile Pro Ala Val Ile Ser His Arg Thr Glu Ser His Val Lys Pro 
            260                 265                 270         


Gly Arg Leu Thr Val Leu Val Ser Gly Leu Glu Ile His Asp Ser Ser 
        275                 280                 285             


Ser Leu Leu Met His Arg Phe Glu Arg Glu Asp Val Asp Asp Ile Lys 
    290                 295                 300                 


Val His Ser Pro Tyr Glu Ile Ser Ile Arg Gln Arg Phe Ile Gly Lys 
305                 310                 315                 320 


Pro Asp Met Ala Tyr Arg Leu Ile Ser Ala Lys Met Pro Glu Val Ile 
                325                 330                 335     


Pro Ile Leu Glu Val Gln Phe Ser Lys Lys Met Glu Leu Leu Glu Asp 
            340                 345                 350         


Ala Leu Val Leu Arg Ser Ala Arg Thr Ser Ser Pro Ala Glu Lys Ser 
        355                 360                 365             


Cys Ser Val Trp His Ala Ala Ser Gly Leu Met Gly Arg Thr Leu His 
    370                 375                 380                 


Arg Glu Pro Pro Ala Gly Asp Gln Glu Gly Thr Ala Leu His Leu Gln 
385                 390                 395                 400 


Thr Ser Leu Pro Ala Leu Ser Glu Ala Asp Thr Gln Glu Leu Thr Gln 
                405                 410                 415     


Gly Phe Arg Pro Met Ser Leu Ser Thr Gln Thr Val Leu Val Met Leu 
            420                 425                 430         


Cys Ser Glu Ser Ala Gly Ala Leu Trp Arg Gln Arg Leu Ser 
        435                 440                 445     


<210> 5368
<211> 631
<212> PRT
<213> Homo sapiens

<400> 5368
Met Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser Val Ser Ser Leu 
            20                  25                  30          


Ile Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His 
        35                  40                  45              


Gly Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp Gly Leu Leu Arg 
    50                  55                  60                  


Gly Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala Val Pro Pro Arg 
65                  70                  75                  80  


Lys Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn Glu Asp Phe Arg 
                85                  90                  95      


Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu 
            100                 105                 110         


Gln Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu Ile 
        115                 120                 125             


Pro Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys Ile Leu Ile Arg 
    130                 135                 140                 


Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser 
145                 150                 155                 160 


Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gln 
                165                 170                 175     


Gly Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser Ser Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ala Ala Asp Lys Pro Leu Ala Phe Ser Gly Trp 
        195                 200                 205             


Ala Ser Gly Cys Pro Ser Gly Thr Leu Ser Asp Ser Gly Arg Asn Ser 
    210                 215                 220                 


Leu Ser Ser Leu Pro Thr Tyr Ser Thr Gly Gly Ala Glu Pro Thr Thr 
225                 230                 235                 240 


Ser Ser Pro Gly Gly His Leu Pro Ser His Gly Ser Gly Arg Gly Ala 
                245                 250                 255     


Leu Pro Gly Pro Ala Arg Gly Val Pro Thr Gly Pro Ser His Ser Asp 
            260                 265                 270         


Ser Gly Arg Ser Ser Ser Ser Lys Ser Thr Gly Ser Leu Gly Gly Arg 
        275                 280                 285             


Val Ala Gly Gly Leu Leu Gly Ser Gly Thr Arg Ala Ser Pro Asp Ser 
    290                 295                 300                 


Ser Ser Cys Gly Glu Arg Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
305                 310                 315                 320 


Asp Glu Ala Leu Leu His Cys Val Leu Glu Gly Lys Leu Arg Asp Arg 
                325                 330                 335     


Glu Ala Glu Leu Gln Gln Leu Arg Asp Ser Leu Asp Glu Asn Glu Ala 
            340                 345                 350         


Thr Met Cys Gln Ala Tyr Glu Glu Arg Gln Arg His Trp Gln Arg Glu 
        355                 360                 365             


Arg Glu Ala Leu Arg Glu Asp Cys Ala Ala Gln Ala Gln Arg Ala Gln 
    370                 375                 380                 


Arg Ala Gln Gln Leu Leu Gln Leu Gln Val Phe Gln Leu Gln Gln Glu 
385                 390                 395                 400 


Lys Arg Gln Leu Gln Asp Asp Phe Ala Gln Leu Leu Gln Glu Arg Glu 
                405                 410                 415     


Gln Leu Glu Arg Arg Cys Ala Thr Leu Glu Arg Glu Gln Arg Glu Leu 
            420                 425                 430         


Gly Pro Arg Leu Glu Glu Thr Lys Trp Glu Val Cys Gln Lys Ser Gly 
        435                 440                 445             


Glu Ile Ser Leu Leu Lys Gln Gln Leu Lys Glu Ser Gln Ala Glu Leu 
    450                 455                 460                 


Val Gln Lys Gly Ser Glu Leu Val Ala Leu Arg Val Ala Leu Arg Glu 
465                 470                 475                 480 


Ala Arg Ala Thr Leu Arg Val Ser Glu Gly Arg Ala Arg Gly Leu Gln 
                485                 490                 495     


Glu Ala Ala Arg Ala Arg Glu Leu Glu Leu Glu Ala Cys Ser Gln Glu 
            500                 505                 510         


Leu Gln Arg His Arg Gln Glu Ala Glu Gln Leu Arg Glu Lys Ala Gly 
        515                 520                 525             


Gln Leu Asp Ala Glu Ala Ala Gly Leu Arg Glu Pro Pro Val Pro Pro 
    530                 535                 540                 


Ala Thr Ala Asp Pro Phe Leu Leu Ala Glu Ser Asp Glu Ala Ser Ala 
545                 550                 555                 560 


Thr Ala Asn Pro Val His Arg Arg Phe Gln Pro Thr Pro Ala Arg Gly 
                565                 570                 575     


Ala Gly Lys Lys Lys Gly Leu Pro Pro Leu His Ile Pro Pro Asp Pro 
            580                 585                 590         


Lys Ala Arg Glu Ser Gln Met Ala Pro Ala Ala Pro Asp Val Pro Ala 
        595                 600                 605             


His Ile Gly Gly Gln Gly Arg Ala Trp Ala Arg Phe Pro Gly Leu Ser 
    610                 615                 620                 


Ser Ala Ala Ser Leu Leu Glu 
625                 630     


<210> 5369
<211> 490
<212> PRT
<213> Homo sapiens

<400> 5369
Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu 
            20                  25                  30          


Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu 
        195                 200                 205             


Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly 
225                 230                 235                 240 


Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu 
                245                 250                 255     


Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser 
            260                 265                 270         


Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu 
        275                 280                 285             


Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala 
    290                 295                 300                 


Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Val Ala 
                325                 330                 335     


Gln Met Leu Ser Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr 
            340                 345                 350         


Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala 
        355                 360                 365             


Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr 
    370                 375                 380                 


Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu 
385                 390                 395                 400 


Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe 
                405                 410                 415     


Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile 
            420                 425                 430         


Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe 
        435                 440                 445             


Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln 
    450                 455                 460                 


Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu 
465                 470                 475                 480 


Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
                485                 490 


<210> 5370
<211> 208
<212> PRT
<213> Homo sapiens

<400> 5370
Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Lys Gly Glu Pro Pro Ala Gln Glu 
65                  70                  75                  80  


Pro Leu Leu Ser Gln Ser Arg Ala Ser Phe Leu Ala Ala Val Val Asp 
                85                  90                  95      


Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu Ser Gly 
            100                 105                 110         


Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu Pro Gly 
        115                 120                 125             


Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala Ala Asn 
    130                 135                 140                 


Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp Gln Asp 
145                 150                 155                 160 


Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro Asn His 
                165                 170                 175     


Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu Asp Lys 
            180                 185                 190         


Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly Leu Gln 
        195                 200                 205             


<210> 5371
<211> 181
<212> PRT
<213> Homo sapiens

<400> 5371
Met Glu Ser Arg Ser Val Ala Gln Ala Gly Val Gln Trp Cys Asp Leu 
1               5                   10                  15      


Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys Gln Phe Ser Tyr Phe 
            20                  25                  30          


Ser Leu Gln Ser Ser Trp Asp Tyr Arg Tyr Val Pro Pro Cys Pro Ala 
        35                  40                  45              


Asn Phe Val Phe Leu Val Glu Met Gly Phe Leu His Val Asp Gln Ala 
    50                  55                  60                  


Gly Leu Lys Leu Leu Thr Ser Gly Ile Asp Phe Ala Thr Arg Lys Ile 
65                  70                  75                  80  


Ala Lys Leu Leu Lys Pro Gln Lys Val Ile Glu Gln Asn Gly Asp Ser 
                85                  90                  95      


Phe Thr Ile His Thr Asn Ser Ser Leu Arg Asn Tyr Phe Val Lys Phe 
            100                 105                 110         


Lys Val Gly Glu Glu Phe Asp Glu Asp Asn Arg Gly Leu Asp Asn Arg 
        115                 120                 125             


Lys Cys Lys Ser Leu Val Ile Trp Asp Asn Asp Arg Leu Thr Cys Ile 
    130                 135                 140                 


Gln Lys Gly Glu Lys Lys Asn Arg Gly Trp Thr His Trp Ile Glu Gly 
145                 150                 155                 160 


Asp Lys Leu His Leu Glu Met Phe Cys Glu Gly Gln Val Cys Lys Gln 
                165                 170                 175     


Thr Phe Gln Arg Ala 
            180     


<210> 5372
<211> 548
<212> PRT
<213> Homo sapiens

<400> 5372
Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 
1               5                   10                  15      


Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
            20                  25                  30          


Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
        35                  40                  45              


Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 
    50                  55                  60                  


Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 
65                  70                  75                  80  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
                85                  90                  95      


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
            100                 105                 110         


Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 
        115                 120                 125             


Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 
    130                 135                 140                 


Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 
145                 150                 155                 160 


Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 
                165                 170                 175     


Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 
            180                 185                 190         


Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 
        195                 200                 205             


Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 
    210                 215                 220                 


Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 
225                 230                 235                 240 


Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 
                245                 250                 255     


Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 
            260                 265                 270         


Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 
        275                 280                 285             


Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 
    290                 295                 300                 


Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 
305                 310                 315                 320 


Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 
                325                 330                 335     


Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 
            340                 345                 350         


Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 
        355                 360                 365             


Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 
    370                 375                 380                 


Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 
385                 390                 395                 400 


Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Gly Glu Val Val 
                405                 410                 415     


Pro Thr Gly Ser Glu Gln Thr Thr Glu Ser Glu Thr Pro Val Pro Ala 
            420                 425                 430         


Ala Ala Glu Thr Ala Asp Pro Leu Phe Tyr Pro Ser Trp Tyr Lys Gly 
        435                 440                 445             


Gln Thr Arg Lys Ala Thr Thr Asn Pro Pro Cys Thr Pro Gly Ser Glu 
    450                 455                 460                 


Gly Leu Gly Gln Ile Gly Pro Pro Gly Ser Glu Asp Ser Asn Val Arg 
465                 470                 475                 480 


Lys Ala Glu Val Ala Ala Ala Ala Ala Ser Glu Arg Ala Ala Val Ser 
                485                 490                 495     


Gly Lys Glu Thr Ser Ala Pro Ala Ala Thr Ser Gln Ile Gly Phe Glu 
            500                 505                 510         


Ala Pro Pro Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly 
        515                 520                 525             


Ala Asp Ser Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn 
    530                 535                 540                 


Ser Leu Asn Glu 
545             


<210> 5373
<211> 457
<212> PRT
<213> Homo sapiens

<400> 5373
Met Phe Pro Lys Phe Ser Leu Arg Ser Met Phe His Gly Ala Gly Gly 
1               5                   10                  15      


Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln Val Lys Gly Ala Val Asp 
            20                  25                  30          


Asp Asp Val Ala Glu Ala Asp Ile Ile Ser Thr Val Glu Phe Asn His 
        35                  40                  45              


Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys Gly Gly Arg Val Val Ile 
    50                  55                  60                  


Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln Ser His Ser Arg Gly Glu 
65                  70                  75                  80  


Tyr Asn Val Tyr Ser Thr Phe Gln Ser His Glu Pro Glu Phe Asp Tyr 
                85                  90                  95      


Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile Asn Lys Ile Arg Trp Leu 
            100                 105                 110         


Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu Ser Thr Asn Asp Lys Thr 
        115                 120                 125             


Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp Lys Arg Pro Glu Gly Tyr 
    130                 135                 140                 


Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg Asp Pro Thr Thr Val Thr 
145                 150                 155                 160 


Thr Leu Arg Val Pro Val Phe Arg Pro Met Asp Leu Met Val Glu Ala 
                165                 170                 175     


Ser Pro Arg Arg Ile Phe Ala Asn Ala His Thr Tyr His Ile Asn Ser 
            180                 185                 190         


Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr Leu Ser Ala Asp Asp Leu 
        195                 200                 205             


Arg Ile Asn Leu Trp His Leu Glu Ile Thr Asp Arg Ser Phe Asn Ile 
    210                 215                 220                 


Val Asp Ile Lys Pro Ala Asn Met Glu Glu Leu Thr Glu Val Ile Thr 
225                 230                 235                 240 


Ala Ala Glu Phe His Pro Asn Ser Cys Asn Thr Phe Val Tyr Ser Ser 
                245                 250                 255     


Ser Lys Gly Thr Ile Arg Leu Cys Asp Met Arg Ala Ser Ala Leu Cys 
            260                 265                 270         


Asp Arg His Ser Lys Leu Phe Glu Glu Pro Glu Asp Pro Ser Asn Arg 
        275                 280                 285             


Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile Ser Asp Val Lys Phe Ser 
    290                 295                 300                 


His Ser Gly Arg Tyr Met Met Thr Arg Asp Tyr Leu Ser Val Lys Ile 
305                 310                 315                 320 


Trp Asp Leu Asn Met Glu Asn Arg Pro Val Glu Thr Tyr Gln Val His 
                325                 330                 335     


Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu Tyr Glu Asn Asp Cys Ile 
            340                 345                 350         


Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly Ser Asp Ser Val Val Met 
        355                 360                 365             


Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met Phe Asp Arg Asn Thr Lys 
    370                 375                 380                 


Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu Asn Asn Lys Pro Arg Thr 
385                 390                 395                 400 


Val Leu Lys Pro Arg Lys Val Cys Ala Ser Gly Lys Arg Lys Lys Asp 
                405                 410                 415     


Glu Ile Ser Val Asp Ser Leu Asp Phe Asn Lys Lys Ile Leu His Thr 
            420                 425                 430         


Ala Trp His Pro Lys Glu Asn Ile Ile Ala Val Ala Thr Thr Asn Asn 
        435                 440                 445             


Leu Tyr Ile Phe Gln Asp Lys Val Asn 
    450                 455         


<210> 5374
<211> 245
<212> PRT
<213> Homo sapiens

<400> 5374
Met Ala Gly Leu Glu Leu Leu Ser Asp Gln Gly Tyr Arg Val Asp Gly 
1               5                   10                  15      


Arg Arg Ala Gly Glu Leu Arg Lys Ile Gln Ala Arg Met Gly Val Phe 
            20                  25                  30          


Ala Gln Ala Asp Gly Ser Ala Tyr Ile Glu Gln Gly Asn Thr Lys Ala 
        35                  40                  45              


Leu Ala Val Val Tyr Gly Pro His Glu Ile Arg Gly Ser Arg Ala Arg 
    50                  55                  60                  


Ala Leu Pro Asp Arg Ala Leu Val Asn Cys Gln Tyr Ser Ser Ala Thr 
65                  70                  75                  80  


Phe Ser Thr Gly Glu Arg Lys Arg Arg Pro His Gly Asp Arg Lys Ser 
                85                  90                  95      


Cys Glu Met Gly Leu Gln Leu Arg Gln Thr Phe Glu Ala Ala Ile Leu 
            100                 105                 110         


Thr Gln Leu His Pro Arg Ser Gln Ile Asp Ile Tyr Val Gln Val Leu 
        115                 120                 125             


Gln Ala Asp Gly Gly Thr Tyr Ala Ala Cys Val Asn Ala Ala Thr Leu 
    130                 135                 140                 


Ala Val Leu Asp Ala Gly Ile Pro Met Arg Asp Phe Val Cys Ala Cys 
145                 150                 155                 160 


Ser Ala Gly Phe Val Asp Gly Thr Ala Leu Ala Asp Leu Ser His Val 
                165                 170                 175     


Glu Glu Ala Ala Gly Gly Pro Gln Leu Ala Leu Ala Leu Leu Pro Ala 
            180                 185                 190         


Ser Gly Gln Ile Ala Leu Leu Glu Met Asp Ala Arg Leu His Glu Asp 
        195                 200                 205             


His Leu Glu Arg Val Leu Glu Ala Ala Ala Gln Ala Ala Arg Asp Val 
    210                 215                 220                 


His Thr Leu Leu Asp Arg Val Val Arg Gln His Val Arg Glu Ala Ser 
225                 230                 235                 240 


Ile Leu Leu Gly Asp 
                245 


<210> 5375
<211> 876
<212> PRT
<213> Homo sapiens

<400> 5375
Met Met Ala Asp Gly Ala Ala Ala Gly Ala Gly Gly Ser Pro Ser Leu 
1               5                   10                  15      


Arg Glu Leu Arg Ala Arg Met Val Ala Ala Ala Asn Glu Ile Ala Lys 
            20                  25                  30          


Glu Arg Arg Lys Gln Asp Val Val Asn Arg Val Ala Thr His Ser Ser 
        35                  40                  45              


Asn Ile Arg Ser Thr Phe Lys Pro Val Ile Asp Gly Ser Met Leu Lys 
    50                  55                  60                  


Asn Asp Ile Lys Gln Arg Leu Ala Arg Glu Arg Arg Glu Glu Lys Arg 
65                  70                  75                  80  


Arg Gln Gln Asp Ala Asn Lys Glu Thr Gln Leu Leu Glu Lys Glu Arg 
                85                  90                  95      


Lys Thr Lys Leu Gln Tyr Glu Lys Gln Met Glu Glu Arg Gln Arg Lys 
            100                 105                 110         


Leu Lys Glu Arg Lys Glu Lys Glu Glu Gln Arg Arg Ile Ala Ala Glu 
        115                 120                 125             


Glu Lys Arg His Gln Lys Asp Glu Ala Gln Lys Glu Lys Phe Thr Ala 
    130                 135                 140                 


Ile Leu Tyr Arg Thr Leu Glu Arg Arg Arg Leu Ala Asp Asp Tyr Gln 
145                 150                 155                 160 


Gln Lys Arg Trp Ser Trp Gly Gly Ser Ala Met Ala Asn Ser Glu Ser 
                165                 170                 175     


Lys Thr Ala Asn Lys Arg Ser Ala Ser Thr Glu Lys Leu Glu Gln Gly 
            180                 185                 190         


Thr Ser Ala Leu Ile Arg Gln Met Pro Leu Ser Ser Ala Gly Leu Gln 
        195                 200                 205             


Asn Ser Val Ala Lys Arg Lys Thr Asp Lys Glu Arg Ser Ser Ser Leu 
    210                 215                 220                 


Asn Arg Arg Asp Ser Asn Leu His Ser Ser Thr Asp Lys Glu Gln Ala 
225                 230                 235                 240 


Glu Arg Lys Pro Arg Val Thr Gly Val Thr Asn Tyr Val Met Gln Tyr 
                245                 250                 255     


Val Thr Val Pro Leu Arg Lys Cys Thr Ser Asp Glu Leu Arg Ala Val 
            260                 265                 270         


Met Phe Pro Met Ser Thr Met Lys Ile Pro Pro Gln Thr Lys Val Glu 
        275                 280                 285             


Glu Ser Pro Leu Glu Lys Val Glu Thr Pro Pro Lys Ala Ser Val Asp 
    290                 295                 300                 


Ala Pro Pro Gln Val Asn Val Glu Val Phe Cys Asn Thr Ser Met Glu 
305                 310                 315                 320 


Ala Ser Pro Lys Ala Gly Val Gly Met Ala Pro Glu Val Ser Thr Asp 
                325                 330                 335     


Ser Phe Pro Val Val Ser Val Asp Val Ser Pro Val Val Ser Thr Tyr 
            340                 345                 350         


Asp Ser Glu Met Ser Met Asp Ala Ser Pro Glu Leu Ser Ile Glu Ala 
        355                 360                 365             


Leu Pro Lys Val Asp Leu Glu Thr Val Pro Lys Val Ser Ile Val Ala 
    370                 375                 380                 


Ser Pro Glu Ala Ser Leu Glu Ala Pro Pro Glu Val Ser Leu Glu Ala 
385                 390                 395                 400 


Leu Pro Glu Val Ser Val Glu Ala Ala Pro Glu Gly Ser Leu Glu Ala 
                405                 410                 415     


Pro Pro Lys Gly Ser Ala Glu Val Ala Pro Lys Glu Ser Val Lys Gly 
            420                 425                 430         


Ser Pro Lys Glu Ser Met Glu Ala Ser Pro Glu Ala Met Val Lys Ala 
        435                 440                 445             


Ser Pro Lys Thr Ser Leu Glu Ala Ser Met Glu Ala Ser Pro Lys Ala 
    450                 455                 460                 


Lys Ala Arg Asp Ala Pro Lys Lys Ser Glu Met Asp Lys Gln Ala Leu 
465                 470                 475                 480 


Ile Pro Ile Ala Lys Lys Arg Leu Ser Ser Tyr Thr Glu Cys Tyr Lys 
                485                 490                 495     


Trp Ser Ser Ser Pro Glu Asn Ala Cys Gly Leu Pro Ser Pro Ile Ser 
            500                 505                 510         


Thr Asn Arg Gln Ile Gln Lys Asn Cys Pro Pro Ser Pro Leu Pro Leu 
        515                 520                 525             


Ile Ser Lys Gln Ser Pro Gln Thr Ser Phe Pro Tyr Lys Ile Met Pro 
    530                 535                 540                 


Ile Gln His Thr Leu Ser Val Gln Ser Ala Ser Ser Thr Val Lys Lys 
545                 550                 555                 560 


Lys Lys Glu Thr Val Ser Lys Thr Thr Asn Arg Cys Glu Ala Leu Ser 
                565                 570                 575     


Gln Arg His Met Ile Tyr Glu Glu Ser Gly Asn Lys Ser Thr Ala Gly 
            580                 585                 590         


Ile Met Asn Ala Glu Ala Ala Thr Lys Ile Leu Thr Glu Leu Arg Arg 
        595                 600                 605             


Leu Ala Arg Glu Gln Arg Glu Lys Glu Glu Glu Glu Arg Gln Arg Glu 
    610                 615                 620                 


Glu Met Gln Gln Arg Val Ile Lys Lys Ser Lys Asp Met Ala Lys Glu 
625                 630                 635                 640 


Ala Val Gly Gly Gln Ala Glu Asp His Leu Lys Leu Lys Asp Gly Gln 
                645                 650                 655     


Gln Gln Asn Glu Thr Lys Lys Lys Lys Gly Trp Leu Asp Gln Glu Asp 
            660                 665                 670         


Gln Glu Ala Pro Leu Gln Lys Gly Asp Ala Lys Ile Lys Ala Gln Glu 
        675                 680                 685             


Glu Ala Asp Lys Arg Lys Lys Glu His Glu Arg Ile Met Leu Gln Asn 
    690                 695                 700                 


Leu Gln Glu Arg Leu Glu Arg Lys Lys Arg Ile Glu Glu Ile Met Lys 
705                 710                 715                 720 


Arg Thr Arg Lys Thr Asp Val Asn Ala Ser Lys Val Thr Glu Thr Ser 
                725                 730                 735     


Ser His Asp Ile Tyr Glu Glu Ala Glu Ala Asp Asn Glu Glu Ser Asp 
            740                 745                 750         


Lys Asp Ser Leu Asn Glu Met Phe Pro Ser Ala Ile Leu Asn Gly Thr 
        755                 760                 765             


Gly Ser Pro Thr Lys Phe Lys Met Pro Phe Asn Asn Ala Lys Lys Met 
    770                 775                 780                 


Thr His Lys Leu Val Phe Leu Glu Asp Gly Thr Ser Gln Val Arg Lys 
785                 790                 795                 800 


Glu Pro Lys Thr Tyr Phe Asn Gly Asp Leu Lys Asn Phe Arg Gln Lys 
                805                 810                 815     


Ser Met Lys Asp Thr Ser Ile Gln Glu Val Val Ser Arg Pro Ser Ser 
            820                 825                 830         


Lys Arg Met Thr Ser His Thr Thr Lys Thr Arg Lys Ala Asp Glu Thr 
        835                 840                 845             


Asn Thr Thr Ser Arg Ser Ser Ala Gln Thr Lys Ser Glu Gly Phe His 
    850                 855                 860                 


Asp Ile Leu Pro Lys Ser Ser Asp Thr Phe Arg Gln 
865                 870                 875     


<210> 5376
<211> 2096
<212> PRT
<213> Homo sapiens

<400> 5376
Met Cys Ser Thr Pro Gly Met Pro Ala Pro Gly Ala Ser Leu Ala Leu 
1               5                   10                  15      


Arg Val Ser Phe Val Asp Val His Pro Asp Val Ile Pro Val Gln Leu 
            20                  25                  30          


Trp Gly Leu Val Gly Glu Arg Arg Gly Glu Tyr Leu Arg Leu Ser Arg 
        35                  40                  45              


Glu Ile Gln Glu Ala Ala Ala Thr Arg Gly Gln Trp Ala Leu Gly Ser 
    50                  55                  60                  


Ala Ser Ala Ser Pro Gly Glu Leu Cys Leu Val Gln Val Gly Leu Leu 
65                  70                  75                  80  


Trp His Arg Cys Arg Val Val Ser Arg Gln Ala Gln Glu Ser Arg Val 
                85                  90                  95      


Phe Leu Leu Asp Glu Gly Arg Thr Ile Thr Ala Gly Ala Gly Ser Leu 
            100                 105                 110         


Ala Pro Gly Arg Arg Glu Phe Phe Asn Leu Pro Ser Glu Val Leu Gly 
        115                 120                 125             


Cys Val Leu Ala Gly Leu Val Pro Ala Gly Cys Gly Ala Gly Ser Gly 
    130                 135                 140                 


Glu Pro Pro Gln His Trp Pro Ala Asp Ala Val Asp Phe Leu Ser Asn 
145                 150                 155                 160 


Leu Gln Gly Lys Glu Val His Gly Cys Val Leu Asp Val Leu Leu Leu 
                165                 170                 175     


His Arg Leu Val Leu Leu Glu Val Pro Asp Val Phe Gln Gln Met Arg 
            180                 185                 190         


Glu Leu Gly Leu Ala Arg Arg Val Pro Asp Ser Leu Phe Arg Ser Leu 
        195                 200                 205             


Leu Glu Arg Tyr Leu Thr Ala Ala Thr Ala Ser Val Gly Ser Gly Val 
    210                 215                 220                 


Pro Val Leu Ser Arg Val Pro Leu Lys Gln Lys Gln Pro Gly Leu Asp 
225                 230                 235                 240 


Tyr Phe Tyr Pro Gln Leu Gln Leu Gly Val Thr Glu Ala Val Val Ile 
                245                 250                 255     


Thr Gln Val Cys His Pro His Arg Ile His Cys Gln Leu Arg Ser Val 
            260                 265                 270         


Ser Gln Glu Ile His Arg Leu Ser Glu Ser Met Ala Gln Val Tyr Arg 
        275                 280                 285             


Gly Ser Thr Gly Thr Gly Asp Glu Asn Ser Thr Ser Ala Thr Trp Glu 
    290                 295                 300                 


Glu Arg Glu Glu Ser Pro Asp Lys Pro Gly Ser Pro Cys Ala Ser Cys 
305                 310                 315                 320 


Gly Leu Asp Gly His Trp Tyr Arg Ala Leu Leu Leu Glu Thr Phe Arg 
                325                 330                 335     


Pro Gln Arg Cys Ala Gln Val Leu His Val Asp Tyr Gly Arg Lys Glu 
            340                 345                 350         


Leu Val Ser Cys Ser Ser Leu Arg Tyr Leu Leu Pro Glu Tyr Phe Arg 
        355                 360                 365             


Met Pro Val Val Thr Tyr Pro Cys Ala Leu Tyr Gly Leu Trp Asp Gly 
    370                 375                 380                 


Gly Arg Gly Trp Ser Arg Ser Gln Val Gly Asp Leu Lys Thr Leu Ile 
385                 390                 395                 400 


Leu Gly Lys Ala Val Asn Ala Lys Ile Glu Phe Tyr Cys Ser Phe Glu 
                405                 410                 415     


His Val Tyr Tyr Val Ser Leu Tyr Gly Glu Asp Gly Ile Asn Leu Asn 
            420                 425                 430         


Arg Val Phe Gly Val Gln Ser Cys Cys Leu Ala Asp Arg Val Leu Gln 
        435                 440                 445             


Ser Gln Ala Thr Glu Glu Glu Glu Pro Glu Thr Ser Gln Ser Gln Ser 
    450                 455                 460                 


Pro Ala Glu Glu Val Asp Glu Glu Ile Ser Leu Pro Ala Leu Arg Ser 
465                 470                 475                 480 


Ile Arg Leu Lys Met Asn Ala Phe Tyr Asp Ala Gln Val Glu Phe Val 
                485                 490                 495     


Lys Asn Pro Ser Glu Phe Trp Ile Arg Leu Arg Lys His Asn Val Thr 
            500                 505                 510         


Phe Ser Lys Leu Met Arg Arg Met Cys Gly Phe Tyr Ser Ser Ala Ser 
        515                 520                 525             


Lys Leu Asp Gly Val Val Leu Lys Pro Glu Pro Asp Asp Leu Cys Cys 
    530                 535                 540                 


Val Lys Trp Lys Glu Asn Gly Tyr Tyr Arg Ala Ile Val Thr Lys Leu 
545                 550                 555                 560 


Asp Asp Lys Ser Val Asp Val Phe Leu Val Asp Arg Gly Asn Ser Glu 
                565                 570                 575     


Asn Val Asp Trp Tyr Asp Val Arg Met Leu Leu Pro Gln Phe Arg Gln 
            580                 585                 590         


Leu Pro Ile Leu Ala Val Lys Cys Thr Leu Ala Asp Ile Trp Pro Leu 
        595                 600                 605             


Gly Lys Thr Trp Ser Gln Glu Ala Val Ser Phe Phe Lys Lys Thr Val 
    610                 615                 620                 


Leu His Lys Glu Leu Val Ile His Ile Leu Asp Lys Gln Asp His Gln 
625                 630                 635                 640 


Tyr Val Ile Glu Ile Leu Asp Glu Ser Arg Thr Gly Glu Glu Asn Ile 
                645                 650                 655     


Ser Lys Val Ile Ala Gln Ala Gly Tyr Ala Lys Tyr Gln Glu Phe Glu 
            660                 665                 670         


Thr Lys Glu Asn Ile Leu Val Asn Ala His Ser Pro Gly His Val Ser 
        675                 680                 685             


Asn His Phe Thr Thr Glu Ser Asn Lys Ile Pro Phe Ala Lys Thr Gly 
    690                 695                 700                 


Glu Gly Glu Gln Lys Ala Lys Arg Glu Asn Lys Thr Thr Ser Val Ser 
705                 710                 715                 720 


Lys Ala Leu Ser Asp Thr Thr Val Val Thr Asn Gly Ser Thr Glu Leu 
                725                 730                 735     


Val Val Gln Glu Lys Val Lys Arg Ala Ser Val Tyr Phe Pro Leu Met 
            740                 745                 750         


Gln Asn Cys Leu Glu Ile Lys Pro Gly Ser Ser Ser Lys Gly Glu Leu 
        755                 760                 765             


Glu Val Gly Ser Thr Val Glu Val Arg Val Ser Tyr Val Glu Asn Pro 
    770                 775                 780                 


Gly Tyr Phe Trp Cys Gln Leu Thr Arg Asn Ile Gln Gly Leu Lys Thr 
785                 790                 795                 800 


Leu Met Ser Asp Ile Gln Tyr Tyr Cys Lys Asn Thr Ala Ala Pro His 
                805                 810                 815     


Gln Arg Asn Thr Leu Ala Cys Leu Ala Lys Arg Thr Val Asn Arg Gln 
            820                 825                 830         


Trp Ser Arg Ala Leu Ile Ser Gly Ile Gln Ser Val Glu His Val Asn 
        835                 840                 845             


Val Thr Phe Val Asp Tyr Gly Asp Arg Glu Met Val Ser Val Lys Asn 
    850                 855                 860                 


Ile Tyr Ser Ile Ser Glu Glu Phe Leu Lys Val Lys Ala Gln Ala Phe 
865                 870                 875                 880 


Arg Cys Ser Leu Tyr Asn Leu Ile Gln Pro Val Gly Gln Asn Pro Phe 
                885                 890                 895     


Val Trp Asp Val Lys Ala Ile Gln Ala Phe Asn Glu Phe Ile Asp Asn 
            900                 905                 910         


Ala Trp Gln Lys Asn Leu Glu Leu Lys Cys Thr Ile Phe Ala Leu Ala 
        915                 920                 925             


Ser Ile Asn Glu Glu Leu Phe Asn Ile Val Asp Leu Leu Thr Pro Phe 
    930                 935                 940                 


Gln Ser Ala Cys His Phe Leu Val Glu Lys Arg Leu Ala Arg Pro Val 
945                 950                 955                 960 


Lys Leu Gln Lys Pro Leu Glu Ser Ser Val Gln Leu His Ser Tyr Phe 
                965                 970                 975     


Tyr Ser Thr His Asp Met Lys Ile Gly Ser Glu Glu Leu Val Tyr Ile 
            980                 985                 990         


Thr His Ile Asp Asp Pro Trp Thr  Phe Tyr Cys Gln Leu  Ala Arg Asn 
        995                 1000                 1005             


Ala Asn  Ile Leu Glu Gln Leu  Ser Cys Ser Ile Thr  Gln Leu Ser 
    1010                 1015                 1020             


Lys Val  Leu Leu Asn Leu Lys  Thr Ser Pro Leu Asn  Pro Gly Thr 
    1025                 1030                 1035             


Leu Cys  Leu Ala Lys Tyr Thr  Asp Gly Asn Trp Tyr  Arg Gly Ile 
    1040                 1045                 1050             


Val Ile  Glu Lys Glu Pro Lys  Lys Val Phe Phe Val  Asp Phe Gly 
    1055                 1060                 1065             


Asn Ile  Tyr Val Val Thr Ser  Asp Asp Leu Leu Pro  Ile Pro Ser 
    1070                 1075                 1080             


Asp Ala  Tyr Asp Val Leu Leu  Leu Pro Met Gln Ala  Val Arg Cys 
    1085                 1090                 1095             


Ser Leu  Ser Asp Ile Pro Asp  His Ile Pro Glu Glu  Val Val Val 
    1100                 1105                 1110             


Trp Phe  Gln Glu Thr Ile Leu  Asp Lys Ser Leu Lys  Ala Leu Val 
    1115                 1120                 1125             


Val Ala  Lys Asp Pro Asp Gly  Thr Leu Ile Ile Glu  Leu Tyr Gly 
    1130                 1135                 1140             


Asp Asn  Ile Gln Ile Ser Ala  Ser Ile Asn Lys Lys  Leu Gly Leu 
    1145                 1150                 1155             


Leu Ser  Tyr Lys Asp Arg Ile  Arg Lys Lys Glu Ser  Glu Val Leu 
    1160                 1165                 1170             


Cys Ser  Thr Thr Glu Thr Leu  Glu Glu Lys Asn Glu  Asn Met Lys 
    1175                 1180                 1185             


Leu Pro  Cys Thr Glu Tyr Leu  Ser Lys Ser Val Gly  Tyr Lys Leu 
    1190                 1195                 1200             


Pro Asn  Lys Glu Ile Leu Glu  Glu Ser Tyr Lys Pro  Gln Ile Asn 
    1205                 1210                 1215             


Ser Ser  Tyr Lys Glu Leu Lys  Leu Leu Gln Ser Leu  Thr Lys Thr 
    1220                 1225                 1230             


Asn Leu  Val Thr Gln Tyr Gln  Asp Ser Val Gly Asn  Lys Asn Ser 
    1235                 1240                 1245             


Gln Val  Phe Pro Leu Thr Thr  Glu Lys Lys Glu Glu  Ile Ser Ala 
    1250                 1255                 1260             


Glu Thr  Pro Leu Lys Thr Ala  Arg Val Glu Ala Thr  Leu Ser Glu 
    1265                 1270                 1275             


Arg Lys  Ile Gly Asp Ser Cys  Asp Lys Asp Leu Pro  Leu Lys Phe 
    1280                 1285                 1290             


Cys Glu  Phe Pro Gln Lys Thr  Ile Met Pro Gly Phe  Lys Thr Thr 
    1295                 1300                 1305             


Val Tyr  Val Ser His Ile Asn  Asp Leu Ser Asp Phe  Tyr Val Gln 
    1310                 1315                 1320             


Leu Ile  Glu Asp Glu Ala Glu  Ile Ser His Leu Ser  Glu Arg Leu 
    1325                 1330                 1335             


Asn Ser  Val Lys Thr Arg Pro  Glu Tyr Tyr Val Gly  Pro Pro Leu 
    1340                 1345                 1350             


Gln Arg  Gly Asp Met Ile Cys  Ala Val Phe Pro Glu  Asp Asn Leu 
    1355                 1360                 1365             


Trp Tyr  Arg Ala Val Ile Lys  Glu Gln Gln Pro Asn  Asp Leu Leu 
    1370                 1375                 1380             


Ser Val  Gln Phe Ile Asp Tyr  Gly Asn Val Ser Val  Val His Thr 
    1385                 1390                 1395             


Asn Lys  Ile Gly Arg Leu Asp  Leu Val Asn Ala Ile  Leu Pro Gly 
    1400                 1405                 1410             


Leu Cys  Ile His Cys Ser Leu  Gln Gly Phe Glu Val  Pro Asp Asn 
    1415                 1420                 1425             


Lys Asn  Ser Lys Lys Met Met  His Tyr Phe Ser Gln  Arg Thr Ser 
    1430                 1435                 1440             


Glu Ala  Ala Ile Arg Cys Glu  Phe Val Lys Phe Gln  Asp Arg Trp 
    1445                 1450                 1455             


Glu Val  Ile Leu Ala Asp Glu  His Gly Ile Ile Ala  Asp Asp Met 
    1460                 1465                 1470             


Ile Ser  Arg Tyr Ala Leu Ser  Glu Lys Ser Gln Val  Glu Leu Ser 
    1475                 1480                 1485             


Thr Gln  Val Ile Lys Ser Ala  Ser Ser Lys Ser Val  Asn Lys Ser 
    1490                 1495                 1500             


Asp Ile  Asp Thr Ser Val Phe  Leu Asn Trp Tyr Asn  Pro Glu Lys 
    1505                 1510                 1515             


Lys Met  Ile Arg Ala Tyr Ala  Thr Val Ile Asp Gly  Pro Glu Tyr 
    1520                 1525                 1530             


Phe Trp  Cys Gln Phe Ala Asp  Thr Glu Lys Leu Gln  Cys Leu Glu 
    1535                 1540                 1545             


Val Glu  Val Gln Thr Ala Gly  Glu Gln Val Ala Asp  Arg Arg Asn 
    1550                 1555                 1560             


Cys Ile  Pro Cys Pro Tyr Ile  Gly Asp Pro Cys Ile  Val Arg Tyr 
    1565                 1570                 1575             


Arg Glu  Asp Gly His Tyr Tyr  Arg Ala Leu Ile Thr  Asn Ile Cys 
    1580                 1585                 1590             


Glu Asp  Tyr Leu Val Ser Val  Arg Leu Val Asp Phe  Gly Asn Ile 
    1595                 1600                 1605             


Glu Asp  Cys Val Asp Pro Lys  Ala Leu Trp Ala Ile  Pro Ser Glu 
    1610                 1615                 1620             


Leu Leu  Ser Val Pro Met Gln  Ala Phe Pro Cys Cys  Leu Ser Gly 
    1625                 1630                 1635             


Phe Asn  Ile Ser Glu Gly Leu  Cys Ser Gln Glu Gly  Asn Asp Tyr 
    1640                 1645                 1650             


Phe Tyr  Glu Ile Ile Thr Glu  Asp Val Leu Glu Ile  Thr Ile Leu 
    1655                 1660                 1665             


Glu Ile  Arg Arg Asp Val Cys  Asp Ile Pro Leu Ala  Ile Val Asp 
    1670                 1675                 1680             


Leu Lys  Ser Lys Gly Lys Ser  Ile Asn Glu Lys Met  Glu Lys Tyr 
    1685                 1690                 1695             


Ser Lys  Thr Gly Ile Lys Ser  Ala Leu Pro Tyr Glu  Asn Ile Asp 
    1700                 1705                 1710             


Ser Glu  Ile Lys Gln Thr Leu  Gly Ser Tyr Asn Leu  Asp Val Gly 
    1715                 1720                 1725             


Leu Lys  Lys Leu Ser Asn Lys  Ala Val Gln Asn Lys  Ile Tyr Met 
    1730                 1735                 1740             


Glu Gln  Gln Thr Asp Glu Leu  Ala Glu Ile Thr Glu  Lys Asp Val 
    1745                 1750                 1755             


Asn Ile  Ile Gly Thr Lys Pro  Ser Asn Phe Arg Asp  Pro Lys Thr 
    1760                 1765                 1770             


Asp Asn  Ile Cys Glu Gly Phe  Glu Asn Pro Cys Lys  Asp Lys Ile 
    1775                 1780                 1785             


Asp Thr  Glu Glu Leu Glu Gly  Glu Leu Glu Cys His  Leu Val Asp 
    1790                 1795                 1800             


Lys Ala  Glu Phe Asp Asp Lys  Tyr Leu Ile Thr Gly  Phe Asn Thr 
    1805                 1810                 1815             


Leu Leu  Pro His Ala Asn Glu  Thr Lys Glu Ile Leu  Glu Leu Asn 
    1820                 1825                 1830             


Ser Leu  Glu Val Pro Leu Ser  Pro Asp Asp Glu Ser  Lys Glu Phe 
    1835                 1840                 1845             


Leu Glu  Leu Glu Ser Ile Glu  Leu Gln Asn Ser Leu  Val Val Asp 
    1850                 1855                 1860             


Glu Glu  Lys Gly Glu Leu Ser  Pro Val Pro Pro Asn  Val Pro Leu 
    1865                 1870                 1875             


Ser Gln  Glu Cys Val Thr Lys  Gly Ala Met Glu Leu  Phe Thr Leu 
    1880                 1885                 1890             


Gln Leu  Pro Leu Ser Cys Glu  Ala Glu Lys Gln Pro  Glu Leu Glu 
    1895                 1900                 1905             


Leu Pro  Thr Ala Gln Leu Pro  Leu Asp Asp Lys Met  Asp Pro Leu 
    1910                 1915                 1920             


Ser Leu  Gly Val Ser Gln Lys  Ala Gln Glu Ser Met  Cys Thr Glu 
    1925                 1930                 1935             


Asp Met  Arg Lys Ser Ser Cys  Val Glu Ser Phe Asp  Asp Gln Arg 
    1940                 1945                 1950             


Arg Met  Ser Leu His Leu His  Gly Ala Asp Cys Asp  Pro Lys Thr 
    1955                 1960                 1965             


Gln Asn  Glu Met Asn Ile Cys  Glu Glu Glu Phe Val  Glu Tyr Lys 
    1970                 1975                 1980             


Asn Arg  Asp Ala Ile Ser Ala  Leu Met Pro Leu Phe  Ser Glu Glu 
    1985                 1990                 1995             


Glu Ser  Ser Asp Gly Ser Lys  His Asn Asn Gly Leu  Pro Asp His 
    2000                 2005                 2010             


Ile Ser  Ala Gln Leu Gln Asn  Thr Tyr Thr Leu Lys  Ala Phe Thr 
    2015                 2020                 2025             


Val Gly  Ser Lys Cys Val Val  Trp Ser Ser Leu Arg  Asn Thr Trp 
    2030                 2035                 2040             


Ser Lys  Cys Glu Ile Leu Glu  Thr Ala Glu Glu Gly  Thr Arg Val 
    2045                 2050                 2055             


Leu Asn  Leu Ser Asn Gly Met  Glu Glu Ile Val Asn  Pro Glu Asn 
    2060                 2065                 2070             


Val Trp  Asn Gly Ile Pro Lys  Leu Asp Lys Ser Pro  Pro Glu Lys 
    2075                 2080                 2085             


Arg Gly  Leu Glu Val Met Glu  Ile 
    2090                 2095     


<210> 5377
<211> 229
<212> PRT
<213> Homo sapiens

<400> 5377
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
65                  70                  75                  80  


Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
            100                 105                 110         


Gly Leu Thr Leu Pro Pro Arg Leu Glu Cys Ser Gly Met Ile Thr Ala 
        115                 120                 125             


His Cys Ser Leu Asn Leu Pro Arg Leu Arg Trp Ser Ser Cys Leu Ser 
    130                 135                 140                 


Pro Leu Leu Arg Leu Gln Val Thr Ile Val Val Leu Gly Asn Lys Cys 
145                 150                 155                 160 


Asp Leu Gln Glu Gln Arg Arg Val Asp Pro Asp Val Ala Gln His Trp 
                165                 170                 175     


Ala Lys Ser Glu Lys Val Lys Leu Trp Glu Val Ser Val Ala Asp Arg 
            180                 185                 190         


Arg Ser Leu Leu Glu Pro Phe Val Tyr Leu Ala Ser Lys Met Thr Gln 
        195                 200                 205             


Pro Gln Ser Lys Ser Ala Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser 
    210                 215                 220                 


Gly Ser Leu Asp Gly 
225                 


<210> 5378
<211> 803
<212> PRT
<213> Homo sapiens

<400> 5378
Met Glu Ser Gly Pro Arg Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala 
1               5                   10                  15      


Val Val Ala Arg Thr Pro Pro Glu Pro Arg Pro Ser Pro Glu Gly Asp 
            20                  25                  30          


Pro Ser Pro Pro Pro Pro Pro Met Ser Ala Leu Val Pro Asp Thr Pro 
        35                  40                  45              


Pro Asp Thr Pro Pro Ala Met Lys Asn Ala Thr Ser Ser Lys Gln Leu 
    50                  55                  60                  


Pro Leu Glu Pro Glu Ser Pro Ser Gly Gln Val Gly Pro Arg Pro Ala 
65                  70                  75                  80  


Pro Pro Gln Glu Glu Ser Pro Ser Ser Glu Ala Lys Ser Arg Gly Pro 
                85                  90                  95      


Thr Pro Pro Ala Met Gly Pro Arg Asp Ala Arg Pro Pro Arg Arg Ser 
            100                 105                 110         


Ser Gln Pro Ser Pro Thr Ala Val Pro Ala Ser Asp Ser Pro Pro Thr 
        115                 120                 125             


Lys Gln Glu Val Lys Lys Ala Gly Glu Arg His Lys Leu Ala Lys Glu 
    130                 135                 140                 


Arg Arg Glu Glu Arg Ala Lys Tyr Leu Ala Ala Lys Lys Ala Val Trp 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Lys Ala Lys Ala Leu Arg Glu Lys Gln Leu Gln 
                165                 170                 175     


Glu Arg Arg Arg Arg Leu Glu Glu Gln Arg Leu Lys Ala Glu Gln Arg 
            180                 185                 190         


Arg Ala Ala Leu Glu Glu Arg Gln Arg Gln Lys Leu Glu Lys Asn Lys 
        195                 200                 205             


Glu Arg Tyr Glu Ala Ala Ile Gln Arg Ser Val Lys Lys Thr Trp Ala 
    210                 215                 220                 


Glu Ile Arg Gln Gln Arg Trp Ser Trp Ala Gly Ala Leu His His Ser 
225                 230                 235                 240 


Ser Pro Gly His Lys Thr Asn Arg Ser Leu Gln Leu Ser Ala Trp Glu 
                245                 250                 255     


Ser Ser Ile Val Asp Arg Leu Met Thr Pro Thr Leu Ser Phe Leu Ala 
            260                 265                 270         


Arg Ser Arg Ser Ala Val Thr Leu Pro Arg Asn Gly Arg Asp Gln Gly 
        275                 280                 285             


Arg Gly Cys Asp Pro Gly Arg Gly Pro Thr Trp Gly Arg Ala Gly Ala 
    290                 295                 300                 


Ser Leu Ala Arg Gly Pro Gln Pro Asp Arg Thr His Pro Ser Ala Ala 
305                 310                 315                 320 


Val Pro Val Cys Pro Arg Ser Ala Ser Ala Ser Pro Leu Thr Pro Cys 
                325                 330                 335     


Ser Val Thr Arg Ser Val His Arg Cys Ala Pro Ala Gly Glu Arg Gly 
            340                 345                 350         


Glu Arg Arg Lys Pro Asn Ala Gly Gly Ser Pro Ala Pro Val Arg Arg 
        355                 360                 365             


Arg Pro Glu Ala Ser Pro Val Gln Lys Lys Glu Lys Lys Asp Lys Glu 
    370                 375                 380                 


Arg Glu Asn Glu Lys Glu Lys Ser Ala Leu Ala Arg Glu Arg Ser Leu 
385                 390                 395                 400 


Lys Lys Arg Gln Ser Leu Pro Ala Ser Pro Arg Ala Arg Leu Ser Ala 
                405                 410                 415     


Ser Thr Ala Ser Glu Leu Ser Pro Lys Ser Lys Ala Arg Pro Ser Ser 
            420                 425                 430         


Pro Ser Thr Ser Trp His Arg Pro Ala Ser Pro Cys Pro Ser Pro Gly 
        435                 440                 445             


Pro Gly His Thr Leu Pro Pro Lys Pro Pro Ser Pro Arg Gly Thr Thr 
    450                 455                 460                 


Ala Ser Pro Lys Gly Arg Val Arg Arg Lys Glu Glu Ala Lys Glu Ser 
465                 470                 475                 480 


Pro Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln Ser Lys Arg Arg Ala 
                485                 490                 495     


Ser Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser Pro Ala Pro Ser Pro 
            500                 505                 510         


Ala Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys Glu Gln Pro Pro Ala 
        515                 520                 525             


Glu Thr Pro Thr Asp Ala Ala Val Leu Thr Ser Pro Pro Ala Pro Ala 
    530                 535                 540                 


Pro Pro Val Thr Pro Ser Lys Pro Met Ala Gly Thr Thr Asp Arg Glu 
545                 550                 555                 560 


Glu Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg Gln Ala Arg Glu Gln 
                565                 570                 575     


Arg Glu Arg Glu Glu Gln Glu Arg Arg Leu Gln Ala Glu Arg Asp Lys 
            580                 585                 590         


Arg Met Arg Glu Glu Gln Leu Ala Arg Glu Ala Glu Ala Arg Ala Glu 
        595                 600                 605             


Arg Glu Ala Glu Ala Arg Arg Arg Glu Glu Gln Glu Ala Arg Glu Lys 
    610                 615                 620                 


Ala Gln Ala Glu Gln Glu Glu Gln Glu Arg Leu Gln Lys Gln Lys Glu 
625                 630                 635                 640 


Glu Ala Glu Ala Arg Ser Arg Glu Glu Ala Glu Arg Gln Arg Leu Glu 
                645                 650                 655     


Arg Glu Lys His Phe Gln Gln Gln Glu Gln Glu Arg Gln Glu Arg Arg 
            660                 665                 670         


Lys Arg Leu Glu Glu Ile Met Lys Arg Thr Arg Lys Ser Glu Val Ser 
        675                 680                 685             


Glu Thr Lys Lys Gln Asp Ser Lys Glu Ala Asn Ala Asn Gly Ser Ser 
    690                 695                 700                 


Pro Glu Pro Val Lys Ala Val Glu Ala Arg Ser Pro Gly Leu Gln Lys 
705                 710                 715                 720 


Glu Ala Val Gln Lys Glu Glu Pro Ile Pro Gln Glu Pro Gln Trp Ser 
                725                 730                 735     


Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu Val Asn Gly Leu Gln Pro 
            740                 745                 750         


Leu Pro Ala His Gln Glu Asn Gly Phe Ser Thr Asn Gly Pro Ser Gly 
        755                 760                 765             


Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr Leu Leu Pro Phe Ala Glu 
    770                 775                 780                 


Ala Glu Ala Phe Leu Lys Lys Ala Val Val Gln Ser Pro Gln Val Thr 
785                 790                 795                 800 


Glu Val Leu 
            


<210> 5379
<211> 374
<212> PRT
<213> Homo sapiens

<400> 5379
Met Arg Ala Pro Met Leu Gln Lys Gln Gln Ala Pro Arg Met Asp Thr 
1               5                   10                  15      


Pro Pro Pro Glu Glu Arg Leu Glu Lys Gln Asn Glu Lys Leu Asn Asn 
            20                  25                  30          


Gln Glu Glu Glu Thr Glu Phe Lys Glu Leu Asp Gly Leu Arg Glu Ala 
        35                  40                  45              


Leu Ala Asn Leu Arg Gly Leu Ser Glu Glu Glu Arg Ser Glu Lys Ala 
    50                  55                  60                  


Met Leu Arg Ser Arg Ile Glu Glu Gln Ser Gln Leu Ile Cys Ile Leu 
65                  70                  75                  80  


Lys Arg Arg Ser Asp Glu Ala Leu Glu Arg Cys Gln Ile Leu Glu Leu 
                85                  90                  95      


Leu Asn Ala Glu Leu Glu Glu Lys Met Met Gln Glu Ala Glu Lys Leu 
            100                 105                 110         


Lys Ala Gln Gly Glu Tyr Ser Arg Lys Leu Glu Glu Arg Phe Met Thr 
        115                 120                 125             


Leu Ala Ala Asn His Glu Leu Met Leu Arg Phe Lys Asp Glu Tyr Lys 
    130                 135                 140                 


Ser Glu Asn Ile Lys Leu Arg Glu Glu Asn Glu Lys Leu Arg Leu Glu 
145                 150                 155                 160 


Asn Ser Ser Leu Phe Ser Gln Ala Leu Lys Asp Glu Glu Ala Lys Val 
                165                 170                 175     


Leu Gln Leu Thr Val Arg Cys Glu Ala Leu Thr Gly Glu Leu Glu Thr 
            180                 185                 190         


Leu Lys Glu Arg Cys Ala Gln Asp Ala Cys Gln Ala Gln Ala Arg Glu 
        195                 200                 205             


Lys Glu Leu Leu Glu Leu Gln Ser Gln Gln Ala Cys Thr His Thr Lys 
    210                 215                 220                 


Glu Thr Glu Gln Leu Arg Ser Gln Leu Gln Thr Leu Lys Gln Gln His 
225                 230                 235                 240 


Gln Gln Ala Val Glu Gln Ile Ala Lys Ala Glu Glu Thr His Ser Ser 
                245                 250                 255     


Leu Ser Gln Glu Leu Gln Ala Arg Leu Gln Thr Val Thr Arg Glu Lys 
            260                 265                 270         


Glu Glu Leu Leu Gln Leu Ser Ile Glu Arg Gly Lys Val Leu Gln Asn 
        275                 280                 285             


Lys Gln Ala Glu Ile Cys Gln Leu Glu Glu Lys Leu Glu Ile Ala Asn 
    290                 295                 300                 


Glu Asp Arg Lys His Ala Leu Glu Arg Phe Glu Gln Glu Ala Val Ala 
305                 310                 315                 320 


Val Asp Ser Asn Leu Arg Val Arg Glu Leu Gln Arg Lys Val Asp Gly 
                325                 330                 335     


Ile Gln Lys Ala Tyr Asp Glu Leu Arg Leu Gln Ser Glu Ala Phe Lys 
            340                 345                 350         


Lys His Ser Leu Asp Leu Leu Ser Lys Glu Arg Glu Leu Asn Gly Lys 
        355                 360                 365             


Leu Arg His Leu Ser Pro 
    370                 


<210> 5380
<211> 194
<212> PRT
<213> Homo sapiens

<400> 5380
Met Glu Asp Gly Leu Leu Glu Ile Met Thr Lys Asp Gly Gly Asp Met 
1               5                   10                  15      


Pro Ala Pro Leu Glu Val Ser Thr Val Pro Ala Val Gly Asp Val Ile 
            20                  25                  30          


Ser Gly Glu Tyr Asn Gly Gly Met Lys Glu Leu Met Glu His Leu Lys 
        35                  40                  45              


Ala Gln Leu Gln Ala Leu Phe Glu Asp Val Arg Ala Met Arg Gly Ala 
    50                  55                  60                  


Leu Asp Glu Gln Ala Ser His Ile Gln Val Leu Ser Asp Asp Val Cys 
65                  70                  75                  80  


Ala Asn Gln Arg Ala Ile Val Ser Met Cys Gln Ile Met Thr Thr Ala 
                85                  90                  95      


Pro Arg Gln Gly Gly Leu Gly Val Val Gly Gly Lys Gly Ser Phe Gln 
            100                 105                 110         


Ser Asp Pro Gln Glu Pro Glu Thr Pro Ser Pro Gly Ile Gly Asp Ser 
        115                 120                 125             


Gly Leu Leu Gly Arg Asp Pro Glu Asp Glu Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Lys Glu Met Pro Ser Pro Ala Thr Pro Ser Ser His Cys Glu Arg Pro 
145                 150                 155                 160 


Glu Ser Pro Cys Ala Gly Leu Leu Gly Gly Asp Gly Pro Leu Val Glu 
                165                 170                 175     


Pro Leu Asp Met Pro Asp Ile Thr Leu Leu Gln Leu Glu Gly Glu Ala 
            180                 185                 190         


Ser Leu 
        


<210> 5381
<211> 426
<212> PRT
<213> Homo sapiens

<400> 5381
Met Ala His Leu Arg Gly Phe Ala Asn Gln His Ser Arg Val Asp Pro 
1               5                   10                  15      


Glu Glu Leu Phe Thr Lys Leu Asp Arg Ile Gly Lys Gly Ser Phe Gly 
            20                  25                  30          


Glu Val Tyr Lys Gly Ile Asp Asn His Thr Lys Glu Val Val Ala Ile 
        35                  40                  45              


Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln 
    50                  55                  60                  


Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Ile Thr Arg 
65                  70                  75                  80  


Tyr Phe Gly Ser Tyr Leu Lys Ser Thr Lys Leu Trp Ile Ile Met Glu 
                85                  90                  95      


Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly Pro Leu 
            100                 105                 110         


Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu 
        115                 120                 125             


Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys Ala Ala 
    130                 135                 140                 


Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr Phe Val 
                165                 170                 175     


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser Ala Tyr 
            180                 185                 190         


Asp Phe Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
        195                 200                 205             


Ala Lys Gly Glu Pro Pro Asn Ser Asp Leu His Pro Met Arg Val Leu 
    210                 215                 220                 


Phe Leu Ile Pro Lys Asn Ser Pro Pro Thr Leu Glu Gly Gln His Ser 
225                 230                 235                 240 


Lys Pro Phe Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Asp Pro Arg 
                245                 250                 255     


Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile Thr Arg 
            260                 265                 270         


Tyr Thr Lys Lys Thr Ser Phe Leu Thr Glu Leu Ile Asp Arg Tyr Lys 
        275                 280                 285             


Arg Trp Lys Ser Glu Gly His Gly Glu Glu Ser Ser Ser Glu Asp Ser 
    290                 295                 300                 


Asp Ile Asp Gly Glu Ala Glu Asp Gly Glu Gln Gly Pro Ile Trp Thr 
305                 310                 315                 320 


Phe Pro Pro Thr Ile Arg Pro Ser Pro His Ser Lys Leu His Lys Gly 
                325                 330                 335     


Thr Ala Leu His Ser Ser Gln Lys Pro Ala Glu Pro Val Lys Arg Gln 
            340                 345                 350         


Pro Arg Ser Gln Cys Leu Ser Thr Leu Val Arg Pro Val Phe Gly Glu 
        355                 360                 365             


Leu Lys Glu Lys His Lys Gln Ser Gly Gly Ser Val Gly Ala Leu Glu 
    370                 375                 380                 


Glu Leu Glu Asn Ala Phe Ser Leu Ala Glu Glu Ser Cys Pro Gly Ile 
385                 390                 395                 400 


Ser Asp Lys Leu Met Val His Leu Val Glu Arg Val Gln Arg Phe Ser 
                405                 410                 415     


His Asn Arg Asn His Leu Thr Ser Thr Arg 
            420                 425     


<210> 5382
<211> 449
<212> PRT
<213> Homo sapiens

<400> 5382
Met Met Leu Ser Thr Glu Gly Arg Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Met Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Thr Ser Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Glu Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Ser Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Met Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Gly Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Ser Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Met Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ala Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Thr Ser 
        355                 360                 365             


Gly Gly Ala Tyr Asp His Ser Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Tyr Gln Ser Asn Leu 
        435                 440                 445             


Ala 
    


<210> 5383
<211> 438
<212> PRT
<213> Homo sapiens

<400> 5383
Met Cys Pro Lys Asn Ala Ser Tyr Tyr Gly Asn Arg Ala Ala Thr Leu 
1               5                   10                  15      


Met Met Leu Gly Arg Phe Arg Glu Ala Leu Gly Asp Ala Gln Gln Ser 
            20                  25                  30          


Val Arg Leu Asp Asp Ser Phe Val Arg Gly His Leu Arg Glu Gly Lys 
        35                  40                  45              


Cys His Leu Ser Leu Gly Asn Ala Met Ala Ala Cys Arg Ser Phe Gln 
    50                  55                  60                  


Arg Ala Leu Glu Leu Asp His Lys Asn Ala Gln Ala Gln Gln Glu Phe 
65                  70                  75                  80  


Lys Asn Ala Asn Ala Val Met Glu Tyr Glu Lys Ile Ala Glu Thr Asp 
                85                  90                  95      


Phe Glu Lys Arg Asp Phe Arg Lys Val Val Phe Cys Met Asp Arg Ala 
            100                 105                 110         


Leu Glu Phe Ala Pro Ala Cys His Arg Phe Lys Ile Leu Lys Ala Glu 
        115                 120                 125             


Cys Leu Ala Met Leu Gly Arg Tyr Pro Glu Ala Gln Ser Val Ala Ser 
    130                 135                 140                 


Asp Ile Leu Arg Met Asp Ser Thr Asn Ala Asp Ala Leu Tyr Val Arg 
145                 150                 155                 160 


Gly Leu Cys Leu Tyr Tyr Glu Asp Cys Ile Glu Lys Ala Val Gln Phe 
                165                 170                 175     


Phe Val Gln Ala Leu Arg Met Ala Pro Asp His Glu Lys Ala Cys Ile 
            180                 185                 190         


Ala Cys Arg Asn Ala Lys Ala Leu Lys Ala Lys Lys Glu Asp Gly Asn 
        195                 200                 205             


Lys Ala Phe Lys Glu Gly Asn Tyr Lys Leu Ala Tyr Glu Leu Tyr Thr 
    210                 215                 220                 


Glu Ala Leu Gly Ile Asp Pro Asn Asn Ile Lys Thr Asn Ala Lys Leu 
225                 230                 235                 240 


Tyr Cys Asn Arg Gly Thr Val Asn Ser Lys Leu Arg Lys Leu Asp Asp 
                245                 250                 255     


Ala Ile Glu Asp Cys Thr Asn Ala Val Lys Leu Asp Asp Thr Tyr Ile 
            260                 265                 270         


Lys Ala Tyr Leu Arg Arg Ala Gln Cys Tyr Met Asp Thr Glu Gln Tyr 
        275                 280                 285             


Glu Glu Ala Val Arg Asp Tyr Glu Lys Val Tyr Gln Thr Glu Lys Thr 
    290                 295                 300                 


Lys Glu His Lys Gln Leu Leu Lys Asn Ala Gln Leu Glu Leu Lys Lys 
305                 310                 315                 320 


Ser Lys Arg Lys Asp Tyr Tyr Lys Ile Leu Gly Val Asp Lys Asn Ala 
                325                 330                 335     


Ser Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Arg Ala Leu Met His 
            340                 345                 350         


His Pro Asp Arg His Ser Gly Ala Ser Ala Glu Val Gln Lys Glu Glu 
        355                 360                 365             


Glu Lys Lys Phe Lys Glu Val Gly Glu Ala Phe Thr Ile Leu Ser Asp 
    370                 375                 380                 


Pro Lys Lys Lys Thr Arg Tyr Asp Ser Gly Gln Asp Leu Asp Glu Glu 
385                 390                 395                 400 


Gly Met Asn Met Gly Asp Phe Asp Pro Asn Asn Ile Phe Lys Ala Phe 
                405                 410                 415     


Phe Gly Gly Pro Gly Gly Phe Ser Phe Glu Ala Ser Gly Pro Gly Asn 
            420                 425                 430         


Phe Phe Phe Gln Phe Gly 
        435             


<210> 5384
<211> 54
<212> PRT
<213> Homo sapiens

<400> 5384
Met Pro Gly Lys Lys Ala Arg Lys Asn Ala Gln Pro Ser Pro Ala Arg 
1               5                   10                  15      


Ala Pro Ala Glu Leu Glu Val Glu Cys Ala Thr Gln Leu Arg Arg Phe 
            20                  25                  30          


Gly Asp Lys Leu Asn Phe Arg Gln Lys Leu Leu Asn Leu Ile Ser Lys 
        35                  40                  45              


Leu Phe Cys Ser Gly Thr 
    50                  


<210> 5385
<211> 467
<212> PRT
<213> Homo sapiens

<400> 5385
Met Ala Ser Val Ala Ala Ala Arg Ala Val Pro Val Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Arg Thr Leu Pro Leu Val Val Ile Leu Gly Ala Thr 
            20                  25                  30          


Gly Thr Gly Lys Ser Thr Leu Ala Leu Gln Leu Gly Gln Arg Leu Gly 
        35                  40                  45              


Gly Glu Ile Val Ser Ala Asp Ser Met Gln Val Tyr Glu Gly Leu Asp 
    50                  55                  60                  


Ile Ile Thr Asn Lys Val Ser Ala Gln Glu Gln Arg Ile Cys Arg His 
65                  70                  75                  80  


His Met Ile Ser Phe Val Asp Pro Leu Val Thr Asn Tyr Thr Val Val 
                85                  90                  95      


Asp Phe Arg Asn Arg Ala Thr Ala Leu Ile Glu Asp Ile Phe Ala Arg 
            100                 105                 110         


Asp Lys Ile Pro Ile Val Val Gly Gly Thr Asn Tyr Tyr Ile Glu Ser 
        115                 120                 125             


Leu Leu Trp Lys Val Leu Val Asn Thr Lys Pro Gln Glu Met Gly Thr 
    130                 135                 140                 


Glu Lys Val Ile Asp Arg Lys Val Glu Leu Glu Lys Glu Asp Gly Leu 
145                 150                 155                 160 


Val Leu His Lys Arg Leu Ser Gln Val Asp Pro Glu Met Ala Ala Lys 
                165                 170                 175     


Leu His Pro His Asp Lys Arg Lys Val Ala Arg Ser Leu Gln Val Phe 
            180                 185                 190         


Glu Glu Thr Gly Ile Ser His Ser Glu Phe Leu His Arg Gln His Thr 
        195                 200                 205             


Glu Glu Gly Gly Gly Pro Leu Gly Gly Pro Leu Lys Phe Ser Asn Pro 
    210                 215                 220                 


Cys Ile Leu Trp Leu His Ala Asp Gln Ala Val Leu Asp Glu Arg Leu 
225                 230                 235                 240 


Asp Lys Arg Val Asp Asp Met Leu Ala Ala Gly Leu Leu Glu Glu Leu 
                245                 250                 255     


Arg Asp Phe His Arg Arg Tyr Asn Gln Lys Asn Val Ser Glu Asn Ser 
            260                 265                 270         


Gln Asp Tyr Gln His Gly Ile Phe Gln Ser Ile Gly Phe Lys Glu Phe 
        275                 280                 285             


His Glu Tyr Leu Ile Thr Glu Gly Lys Cys Thr Leu Glu Thr Ser Asn 
    290                 295                 300                 


Gln Leu Leu Lys Lys Gly Ile Glu Ala Leu Lys Gln Val Thr Lys Arg 
305                 310                 315                 320 


Tyr Ala Arg Lys Gln Asn Arg Trp Val Lys Asn Arg Phe Leu Ser Arg 
                325                 330                 335     


Pro Gly Pro Ile Val Pro Pro Val Tyr Gly Leu Glu Val Ser Asp Val 
            340                 345                 350         


Ser Lys Trp Glu Glu Ser Val Leu Glu Pro Ala Leu Glu Ile Val Gln 
        355                 360                 365             


Ser Phe Ile Gln Gly His Lys Pro Thr Ala Thr Pro Ile Lys Met Pro 
    370                 375                 380                 


Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr His Leu Cys Asp Leu Cys 
385                 390                 395                 400 


Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp Ala Ala His Ile Lys Ser 
                405                 410                 415     


Lys Ser His Leu Asn Gln Leu Lys Lys Arg Arg Arg Leu Asp Ser Asp 
            420                 425                 430         


Ala Val Asn Thr Ile Glu Ser Gln Ser Val Ser Pro Asp His Asn Lys 
        435                 440                 445             


Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln Asn Asp Gln Glu Leu Lys 
    450                 455                 460                 


Cys Ser Val 
465         


<210> 5386
<211> 185
<212> PRT
<213> Homo sapiens

<400> 5386
Met Gly Val Asn Leu Thr Arg Ser Asn Lys Glu Thr Val Lys His Ser 
1               5                   10                  15      


Asp Val Leu Phe Leu Ala Val Lys Pro His Ile Ile Pro Phe Ile Leu 
            20                  25                  30          


Asp Glu Ile Gly Ala Asp Val Gln Ala Arg His Ile Val Val Ser Cys 
        35                  40                  45              


Ala Ala Gly Val Thr Ile Ser Ser Val Glu Lys Lys Leu Met Ala Phe 
    50                  55                  60                  


Gln Pro Ala Pro Lys Val Ile Arg Cys Met Thr Asn Thr Pro Val Val 
65                  70                  75                  80  


Val Gln Glu Gly Ala Thr Val Tyr Ala Thr Gly Thr His Ala Leu Val 
                85                  90                  95      


Glu Asp Gly Gln Leu Leu Glu Gln Leu Met Ser Ser Val Gly Phe Cys 
            100                 105                 110         


Thr Glu Val Glu Glu Asp Leu Ile Asp Ala Val Thr Gly Leu Ser Gly 
        115                 120                 125             


Ser Gly Pro Ala Tyr Gln Ser Met Ala Asp Gln Glu Lys Ile Ser Pro 
    130                 135                 140                 


Ala Ala Leu Lys Lys Thr Leu Leu Asp Arg Val Lys Leu Glu Ser Pro 
145                 150                 155                 160 


Thr Val Ser Thr Leu Thr Pro Ser Ser Pro Gly Lys Leu Leu Thr Arg 
                165                 170                 175     


Ser Leu Ala Leu Gly Gly Lys Lys Asp 
            180                 185 


<210> 5387
<211> 319
<212> PRT
<213> Homo sapiens

<400> 5387
Met Ser Val Gly Phe Ile Gly Ala Gly Gln Leu Ala Met Leu Trp Arg 
1               5                   10                  15      


Gly Ala Ser Arg Pro Gln His Pro Val Gly Ser Gln Asp Asn Ser Gln 
            20                  25                  30          


Leu Pro Arg Asn Glu Pro Ala His Gly Val Arg Ala Gln Glu Asp Gly 
        35                  40                  45              


Cys Glu Pro Asp Thr Gln Gln Gln Gly Asp Gly Glu Ala Gln Arg Arg 
    50                  55                  60                  


Pro Val Ser Gly Cys Glu Ala His Ile Ile Pro Phe Ile Leu Asp Glu 
65                  70                  75                  80  


Ile Gly Ala Asp Val Gln Ala Arg His Ile Val Val Ser Cys Ala Ala 
                85                  90                  95      


Gly Val Thr Ile Ser Ser Val Glu Lys Lys Leu Met Ala Phe Gln Pro 
            100                 105                 110         


Ala Pro Lys Val Ile Arg Cys Met Thr Asn Thr Pro Val Val Val Gln 
        115                 120                 125             


Glu Gly Ala Thr Val Tyr Ala Thr Gly Thr His Ala Leu Val Glu Asp 
    130                 135                 140                 


Gly Gln Leu Leu Glu Gln Leu Met Ser Ser Val Gly Phe Cys Thr Glu 
145                 150                 155                 160 


Val Glu Glu Asp Leu Ile Asp Ala Val Thr Gly Leu Ser Gly Ser Gly 
                165                 170                 175     


Pro Ala Tyr Ala Phe Met Ala Leu Asp Ala Leu Ala Asp Gly Gly Val 
            180                 185                 190         


Lys Met Gly Leu Pro Arg Arg Leu Ala Ile Gln Leu Gly Ala Gln Ala 
        195                 200                 205             


Leu Leu Gly Ala Ala Lys Met Leu Leu Asp Ser Glu Gln His Pro Cys 
    210                 215                 220                 


Gln Leu Lys Asp Asn Val Cys Ser Pro Gly Gly Ala Thr Ile His Ala 
225                 230                 235                 240 


Leu His Phe Leu Glu Ser Gly Gly Phe Arg Ser Leu Leu Ile Asn Ala 
                245                 250                 255     


Val Glu Ala Ser Cys Ile Arg Thr Arg Glu Leu Gln Ser Met Ala Asp 
            260                 265                 270         


Gln Glu Lys Ile Ser Pro Ala Ala Leu Lys Lys Thr Leu Leu Asp Arg 
        275                 280                 285             


Val Lys Leu Glu Ser Pro Thr Val Ser Thr Leu Thr Pro Ser Ser Pro 
    290                 295                 300                 


Gly Lys Leu Leu Thr Arg Ser Leu Ala Leu Gly Gly Lys Lys Asp 
305                 310                 315                 


<210> 5388
<211> 235
<212> PRT
<213> Homo sapiens

<400> 5388
Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg 
65                  70                  75                  80  


Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala 
                85                  90                  95      


Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys 
            100                 105                 110         


Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met 
        115                 120                 125             


Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr 
    130                 135                 140                 


Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala 
145                 150                 155                 160 


Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys 
                165                 170                 175     


Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr 
            180                 185                 190         


Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His 
        195                 200                 205             


Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly 
    210                 215                 220                 


Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
225                 230                 235 


<210> 5389
<211> 1290
<212> PRT
<213> Homo sapiens

<400> 5389
Met Ser Gly Pro Leu Glu Gly Ala Asp Gly Gly Gly Asp Pro Arg Pro 
1               5                   10                  15      


Gly Glu Ser Phe Cys Pro Gly Gly Val Pro Ser Pro Gly Pro Pro Gln 
            20                  25                  30          


His Arg Pro Cys Pro Gly Pro Ser Leu Ala Asp Asp Thr Asp Ala Asn 
        35                  40                  45              


Ser Asn Gly Ser Ser Gly Asn Glu Ser Asn Gly His Glu Ser Arg Gly 
    50                  55                  60                  


Ala Ser Gln Arg Ser Ser His Ser Ser Ser Ser Gly Asn Gly Lys Asp 
65                  70                  75                  80  


Ser Ala Leu Leu Glu Thr Thr Glu Ser Ser Lys Ser Thr Asn Ser Gln 
                85                  90                  95      


Ser Pro Ser Pro Pro Ser Ser Ser Ile Ala Tyr Ser Leu Leu Ser Ala 
            100                 105                 110         


Ser Ser Glu Gln Asp Asn Pro Ser Thr Ser Gly Cys Ser Ser Glu Gln 
        115                 120                 125             


Ser Ala Arg Ala Arg Thr Gln Lys Glu Leu Met Thr Ala Leu Arg Glu 
    130                 135                 140                 


Leu Lys Leu Arg Leu Pro Pro Glu Arg Arg Gly Lys Gly Arg Ser Gly 
145                 150                 155                 160 


Thr Leu Ala Thr Leu Gln Tyr Ala Leu Ala Cys Val Lys Gln Val Gln 
                165                 170                 175     


Ala Asn Gln Glu Tyr Tyr Gln Gln Trp Ser Leu Glu Glu Gly Glu Pro 
            180                 185                 190         


Cys Ser Met Asp Met Ser Thr Tyr Thr Leu Glu Glu Leu Glu His Ile 
        195                 200                 205             


Thr Ser Glu Tyr Thr Leu Gln Asn Gln Asp Thr Phe Ser Val Ala Val 
    210                 215                 220                 


Ser Phe Leu Thr Gly Arg Ile Val Tyr Ile Ser Glu Gln Ala Ala Val 
225                 230                 235                 240 


Leu Leu Arg Cys Lys Arg Asp Val Phe Arg Gly Thr Arg Phe Ser Glu 
                245                 250                 255     


Leu Leu Ala Pro Gln Asp Val Gly Val Phe Tyr Gly Ser Thr Ala Pro 
            260                 265                 270         


Ser Arg Leu Pro Thr Trp Gly Thr Gly Ala Ser Ala Gly Ser Gly Leu 
        275                 280                 285             


Arg Asp Phe Thr Gln Glu Lys Ser Val Phe Cys Arg Ile Arg Gly Gly 
    290                 295                 300                 


Pro Asp Arg Asp Pro Gly Pro Arg Tyr Gln Pro Phe Arg Leu Thr Pro 
305                 310                 315                 320 


Tyr Val Thr Lys Ile Arg Val Ser Asp Gly Ala Pro Ala Gln Pro Cys 
                325                 330                 335     


Cys Leu Leu Ile Ala Glu Arg Ile His Ser Gly Tyr Glu Ala Pro Arg 
            340                 345                 350         


Ile Pro Pro Asp Lys Arg Ile Phe Thr Thr Arg His Thr Pro Ser Cys 
        355                 360                 365             


Leu Phe Gln Asp Val Asp Glu Arg Ala Ala Pro Leu Leu Gly Tyr Leu 
    370                 375                 380                 


Pro Gln Asp Leu Leu Gly Ala Pro Val Leu Leu Phe Leu His Pro Glu 
385                 390                 395                 400 


Asp Arg Pro Leu Met Leu Ala Ile His Lys Lys Ile Leu Gln Leu Ala 
                405                 410                 415     


Gly Gln Pro Phe Asp His Ser Pro Ile Arg Phe Cys Ala Arg Asn Gly 
            420                 425                 430         


Glu Tyr Val Thr Met Asp Thr Ser Trp Ala Gly Phe Val His Pro Trp 
        435                 440                 445             


Ser Arg Lys Val Ala Phe Val Leu Gly Arg His Lys Val Arg Thr Ala 
    450                 455                 460                 


Pro Leu Asn Glu Asp Val Phe Thr Pro Pro Ala Pro Ser Pro Ala Pro 
465                 470                 475                 480 


Ser Leu Asp Thr Asp Ile Gln Glu Leu Ser Glu Gln Ile His Arg Leu 
                485                 490                 495     


Leu Leu Gln Pro Val His Ser Pro Ser Pro Thr Gly Leu Cys Gly Val 
            500                 505                 510         


Gly Ala Val Thr Ser Pro Gly Pro Leu His Ser Pro Gly Ser Ser Ser 
        515                 520                 525             


Asp Ser Asn Gly Gly Asp Ala Glu Gly Pro Gly Pro Pro Ala Pro Val 
    530                 535                 540                 


Thr Phe Gln Gln Ile Cys Lys Asp Val His Leu Val Lys His Gln Gly 
545                 550                 555                 560 


Gln Gln Leu Phe Ile Glu Ser Arg Ala Arg Pro Gln Ser Arg Pro Arg 
                565                 570                 575     


Leu Pro Ala Thr Gly Thr Phe Lys Ala Lys Ala Leu Pro Cys Gln Ser 
            580                 585                 590         


Pro Asp Pro Glu Leu Glu Ala Gly Ser Ala Pro Val Gln Ala Pro Leu 
        595                 600                 605             


Ala Leu Val Pro Glu Glu Ala Glu Arg Lys Glu Ala Ser Ser Cys Ser 
    610                 615                 620                 


Tyr Gln Gln Ile Asn Cys Leu Asp Ser Ile Leu Arg Tyr Leu Glu Ser 
625                 630                 635                 640 


Cys Asn Leu Pro Ser Thr Thr Lys Arg Lys Cys Ala Ser Ser Ser Ser 
                645                 650                 655     


Tyr Thr Thr Ser Ser Ala Ser Asp Asp Asp Arg Gln Arg Thr Gly Pro 
            660                 665                 670         


Val Ser Val Gly Thr Lys Lys Asp Pro Pro Ser Ala Ala Leu Ser Gly 
        675                 680                 685             


Glu Gly Ala Thr Pro Arg Lys Glu Pro Val Val Gly Gly Thr Leu Ser 
    690                 695                 700                 


Pro Leu Ala Leu Ala Asn Lys Ala Glu Ser Val Val Ser Val Thr Ser 
705                 710                 715                 720 


Gln Cys Ser Phe Ser Ser Thr Ile Val His Val Gly Asp Lys Lys Pro 
                725                 730                 735     


Pro Glu Ser Asp Ile Ile Met Met Glu Asp Leu Pro Gly Leu Ala Pro 
            740                 745                 750         


Gly Pro Ala Pro Ser Pro Ala Pro Ser Pro Thr Val Ala Pro Asp Pro 
        755                 760                 765             


Ala Pro Asp Ala Tyr Arg Pro Val Gly Leu Thr Lys Ala Val Leu Ser 
    770                 775                 780                 


Leu His Thr Gln Lys Glu Glu Gln Ala Phe Leu Ser Arg Phe Arg Asp 
785                 790                 795                 800 


Leu Gly Arg Leu Arg Gly Leu Asp Ser Ser Ser Thr Ala Pro Ser Ala 
                805                 810                 815     


Leu Gly Glu Arg Gly Cys His His Gly Pro Ala Pro Pro Ser Arg Arg 
            820                 825                 830         


His His Cys Arg Ser Lys Ala Lys Arg Ser Arg His His Gln Asn Pro 
        835                 840                 845             


Arg Ala Glu Ala Pro Cys Tyr Val Ser His Pro Ser Pro Val Pro Pro 
    850                 855                 860                 


Ser Thr Pro Trp Pro Thr Pro Pro Ala Thr Thr Pro Phe Pro Ala Val 
865                 870                 875                 880 


Val Gln Pro Tyr Pro Leu Pro Val Phe Ser Pro Arg Gly Gly Pro Gln 
                885                 890                 895     


Pro Leu Pro Pro Ala Pro Thr Ser Val Pro Pro Ala Ala Phe Pro Ala 
            900                 905                 910         


Pro Leu Val Thr Pro Met Val Ala Leu Val Leu Pro Asn Tyr Leu Phe 
        915                 920                 925             


Pro Thr Pro Ser Ser Tyr Pro Tyr Gly Ala Leu Gln Thr Pro Ala Glu 
    930                 935                 940                 


Gly Pro Pro Thr Pro Ala Ser His Ser Pro Ser Pro Ser Leu Pro Ala 
945                 950                 955                 960 


Leu Ala Pro Ser Pro Pro His Arg Pro Asp Ser Pro Leu Phe Asn Ser 
                965                 970                 975     


Arg Cys Ser Ser Pro Leu Gln Leu Asn Leu Leu Gln Leu Glu Glu Leu 
            980                 985                 990         


Pro Arg Ala Glu Gly Ala Ala Val  Ala Gly Gly Pro Gly  Ser Ser Ala 
        995                 1000                 1005             


Gly Pro  Pro Pro Pro Ser Ala  Glu Ala Ala Glu Pro  Glu Ala Arg 
    1010                 1015                 1020             


Leu Ala  Glu Val Thr Glu Ser  Ser Asn Gln Asp Ala  Leu Ser Gly 
    1025                 1030                 1035             


Ser Ser  Asp Leu Leu Glu Leu  Leu Leu Gln Glu Asp  Ser Arg Ser 
    1040                 1045                 1050             


Gly Thr  Gly Ser Ala Ala Ser  Gly Ser Leu Gly Ser  Gly Leu Gly 
    1055                 1060                 1065             


Ser Gly  Ser Gly Ser Gly Ser  His Glu Gly Gly Ser  Thr Ser Ala 
    1070                 1075                 1080             


Ser Ile  Thr Arg Ser Ser Gln  Ser Ser His Thr Ser  Lys Tyr Phe 
    1085                 1090                 1095             


Gly Ser  Ile Asp Ser Ser Glu  Ala Glu Ala Gly Ala  Ala Arg Gly 
    1100                 1105                 1110             


Gly Ala  Glu Pro Gly Asp Gln  Val Ile Lys Tyr Val  Leu Gln Asp 
    1115                 1120                 1125             


Pro Ile  Trp Leu Leu Met Ala  Asn Ala Asp Gln Arg  Val Met Met 
    1130                 1135                 1140             


Thr Tyr  Gln Val Pro Ser Arg  Asp Met Thr Ser Val  Leu Lys Gln 
    1145                 1150                 1155             


Asp Arg  Glu Arg Leu Arg Ala  Met Gln Lys Gln Gln  Pro Arg Phe 
    1160                 1165                 1170             


Ser Glu  Asp Gln Arg Arg Glu  Leu Gly Ala Val His  Ser Trp Val 
    1175                 1180                 1185             


Arg Lys  Gly Gln Leu Pro Arg  Ala Leu Asp Val Met  Ala Cys Val 
    1190                 1195                 1200             


Asp Cys  Gly Ser Ser Thr Gln  Asp Pro Gly His Pro  Asp Asp Pro 
    1205                 1210                 1215             


Leu Phe  Ser Glu Leu Asp Gly  Leu Gly Leu Glu Pro  Met Glu Glu 
    1220                 1225                 1230             


Gly Gly  Gly Glu Gln Gly Ser  Ser Gly Gly Gly Ser  Gly Glu Gly 
    1235                 1240                 1245             


Glu Gly  Cys Glu Glu Ala Gln  Gly Gly Ala Lys Ala  Ser Ser Ser 
    1250                 1255                 1260             


Gln Asp  Leu Ala Met Glu Glu  Glu Glu Glu Gly Arg  Ser Ser Ser 
    1265                 1270                 1275             


Ser Pro  Ala Leu Pro Thr Ala  Gly Asn Cys Thr Ser  
    1280                 1285                 1290 


<210> 5390
<211> 673
<212> PRT
<213> Homo sapiens

<400> 5390
Met Glu Lys Ala Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys 
1               5                   10                  15      


His Leu Lys Thr Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser 
            20                  25                  30          


Glu Ser His Leu Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr 
        35                  40                  45              


Glu Leu Glu Ala Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val 
    50                  55                  60                  


Glu Leu Leu Leu Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe 
65                  70                  75                  80  


Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ile Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Glu His Leu Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn 
        115                 120                 125             


Leu Ser Ser Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn 
    130                 135                 140                 


Thr Asn Leu Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn 
                165                 170                 175     


Arg Phe Ser Gln Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln 
            180                 185                 190         


Ile His Lys Arg Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys 
        195                 200                 205             


Ser Leu Glu Thr Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn 
    210                 215                 220                 


Lys Asn Glu Ala Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val 
225                 230                 235                 240 


Ala Leu Lys Lys Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe 
                245                 250                 255     


Thr Gly Ala Ile Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala 
            260                 265                 270         


Lys Leu Ser Glu Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr 
        275                 280                 285             


Glu Lys Ile Val Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr 
    290                 295                 300                 


Met Lys Lys Gln Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu 
305                 310                 315                 320 


Asp His Gly Lys Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser 
                325                 330                 335     


Ile Glu Tyr Glu Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys 
            340                 345                 350         


Leu Arg Phe Pro Cys Arg Ile Thr Glu Ser Lys Asn Met Asn Ile Leu 
        355                 360                 365             


Ile Val Leu Asp Met Leu Cys Tyr Ile Ser Ser Glu Lys Thr Thr Leu 
    370                 375                 380                 


Ala Ala Leu Lys Asp Glu Val Val Ser Val Glu Asn Glu Leu Ser Glu 
385                 390                 395                 400 


Leu Gln Glu Val Glu Lys Lys Gln Lys Thr Leu Ile Glu Met Tyr Lys 
                405                 410                 415     


Thr Gln Val Gln Lys Leu Gln Glu Ala Ala Glu Ile Val Lys Ser Arg 
            420                 425                 430         


Cys Glu Asn Leu Leu His Lys Asn Asn Gln Ile Thr Lys Thr Lys Asn 
        435                 440                 445             


Lys Asn Val Glu Lys Met Arg Gly Gln Met Glu Ser His Leu Lys Glu 
    450                 455                 460                 


Leu Glu Arg Val Cys Asp Ser Leu Thr Ala Ala Glu Arg Arg Leu His 
465                 470                 475                 480 


Glu Cys Gln Glu Ser Leu Gln Cys Cys Lys Gly Lys Cys Ala Asp Gln 
                485                 490                 495     


Glu His Thr Ile Arg Glu Leu Gln Gly Gln Val Asp Gly Asn His Asn 
            500                 505                 510         


Leu Leu Thr Lys Leu Ser Leu Glu Glu Glu Asn Cys Leu Ile Gln Leu 
        515                 520                 525             


Lys Cys Glu Asn Leu Gln Gln Lys Leu Glu Gln Met Asp Ala Glu Asn 
    530                 535                 540                 


Lys Glu Leu Glu Lys Lys Leu Ala Asn Gln Glu Glu Cys Leu Lys His 
545                 550                 555                 560 


Ser Asn Leu Lys Phe Lys Glu Lys Ser Ala Glu Tyr Thr Ala Leu Ala 
                565                 570                 575     


Arg Gln Leu Glu Ala Ala Leu Glu Glu Gly Arg Gln Lys Val Ala Glu 
            580                 585                 590         


Glu Ile Glu Lys Met Ser Ser Arg Glu Ser Ala Leu Gln Ile Lys Ile 
        595                 600                 605             


Leu Asp Leu Glu Thr Glu Leu Arg Lys Lys Asn Glu Glu Gln Asn Gln 
    610                 615                 620                 


Leu Val Cys Lys Met Asn Ser Lys Ala Gln His Gln Glu Val Cys Leu 
625                 630                 635                 640 


Lys Glu Val Gln Asn Ser Leu Glu Lys Ser Glu Asn Gln Asn Glu Ser 
                645                 650                 655     


Ile Lys Asn Tyr Leu Gln Phe Leu Lys Thr Ser Tyr Val Thr Met Phe 
            660                 665                 670         


Glu 
    


<210> 5391
<211> 265
<212> PRT
<213> Homo sapiens

<400> 5391
Met Asp Asp Lys Ala Ser Val Gly Lys Ile Ser Val Ser Ser Asp Ser 
1               5                   10                  15      


Val Ser Thr Leu Asn Ser Glu Asp Phe Val Leu Val Ser Arg Gln Gly 
            20                  25                  30          


Asp Glu Thr Pro Ser Thr Asn Asn Gly Ser Asp Asp Glu Lys Thr Gly 
        35                  40                  45              


Leu Lys Ile Val Gly Asn Gly Ser Glu Gln Gln Leu Gln Lys Glu Leu 
    50                  55                  60                  


Ala Asp Val Leu Met Asp Pro Pro Met Asp Asp Gln Pro Gly Glu Lys 
65                  70                  75                  80  


Glu Leu Val Lys Arg Ser Gln Leu Asp Gly Glu Gly Asp Gly Pro Leu 
                85                  90                  95      


Ser Asn Gln Leu Ser Ala Ser Ser Thr Ile Asn Pro Val Pro Leu Val 
            100                 105                 110         


Gly Leu Gln Lys Pro Glu Met Ser Leu Pro Val Lys Pro Gly Gln Gly 
        115                 120                 125             


Asp Ser Glu Ala Ser Ser Pro Phe Thr Pro Val Ala Asp Glu Asp Ser 
    130                 135                 140                 


Val Val Phe Ser Lys Leu Thr Tyr Leu Gly Cys Ala Ser Val Asn Ala 
145                 150                 155                 160 


Pro Arg Ser Glu Val Glu Ala Leu Arg Met Met Ser Ile Leu Arg Ser 
                165                 170                 175     


Gln Cys Gln Ile Ser Leu Asp Val Thr Leu Ser Val Pro Asn Val Ser 
            180                 185                 190         


Glu Gly Ile Val Arg Leu Leu Asp Pro Gln Thr Asn Thr Glu Ile Ala 
        195                 200                 205             


Asn Tyr Pro Ile Tyr Lys Ile Leu Phe Cys Val Arg Gly His Asp Gly 
    210                 215                 220                 


Thr Pro Glu Ser Asp Cys Phe Ala Phe Thr Glu Ser His Tyr Asn Ala 
225                 230                 235                 240 


Glu Leu Phe Arg Ile His Val Phe Arg Cys Glu Ile Gln Glu Ala Val 
                245                 250                 255     


Ser Pro Gln Glu Lys Thr Leu Cys Lys 
            260                 265 


<210> 5392
<211> 211
<212> PRT
<213> Homo sapiens

<400> 5392
Met Trp Ala Ser Leu Ser Leu Asp His Pro Ser Ala Lys Glu Asn Gln 
1               5                   10                  15      


Ala Leu Arg Leu Ile Glu Met Arg Glu Glu Asn Gly Asn Val Pro Lys 
            20                  25                  30          


Thr Glu Gln Ala Gly Ser Leu Lys Pro Leu Arg Asp Thr Gly Lys Ser 
        35                  40                  45              


Asn Leu Lys Glu Lys Lys Ala Asn Ser Lys Leu Lys Gln Ile Glu Lys 
    50                  55                  60                  


Glu Tyr Thr Gln Lys Leu Ala Lys Ser Ser Gln Ile Ile Ala Glu Leu 
65                  70                  75                  80  


Gln Thr Thr Ile Ser Ser Leu Lys Glu Glu Asn Ser Gln Gln Gln Leu 
                85                  90                  95      


Ala Ala Glu Arg Arg Leu Gln Asp Val Arg Gln Lys Phe Glu Asp Glu 
            100                 105                 110         


Lys Lys Gln Leu Ile Arg Asp Asn Asp Gln Ala Ile Lys Val Leu Gln 
        115                 120                 125             


Asp Glu Leu Glu Asn Arg Ser Asn Gln Val Arg Cys Ala Glu Lys Lys 
    130                 135                 140                 


Leu Gln His Lys Glu Leu Glu Ser Gln Glu Gln Ile Thr Tyr Ile Arg 
145                 150                 155                 160 


Gln Glu Tyr Glu Thr Lys Leu Lys Gly Leu Met Pro Ala Ser Leu Arg 
                165                 170                 175     


Gln Glu Leu Glu Asp Thr Ile Ser Ser Leu Lys Ser Gln Val Asn Phe 
            180                 185                 190         


Leu Gln Lys Arg Ala Ser Ile Leu Gln Glu Glu Leu Thr Thr Tyr Gln 
        195                 200                 205             


Gly Arg Arg 
    210     


<210> 5393
<211> 288
<212> PRT
<213> Homo sapiens

<400> 5393
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Thr Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Thr His Gly Thr Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Thr Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu Asp Gly Asn Arg Asp Thr Pro Leu His Trp Ala Ala Phe Lys 
        115                 120                 125             


Asn Asn Ala Glu Cys Val Arg Ala Leu Leu Glu Ser Gly Ala Ser Val 
    130                 135                 140                 


Asn Ala Leu Asp Tyr Asn Asn Asp Thr Pro Leu Ser Trp Ala Ala Met 
145                 150                 155                 160 


Lys Gly Asn Leu Glu Ser Val Ser Ile Leu Leu Asp Tyr Gly Ala Glu 
                165                 170                 175     


Val Arg Val Ile Asn Leu Ile Gly Gln Thr Pro Ile Ser Arg Leu Val 
            180                 185                 190         


Ala Leu Leu Val Arg Gly Leu Gly Thr Glu Lys Glu Asp Ser Cys Phe 
        195                 200                 205             


Glu Leu Leu His Arg Ala Val Gly His Phe Glu Leu Arg Lys Asn Gly 
    210                 215                 220                 


Thr Met Pro Arg Glu Val Ala Arg Asp Pro Gln Leu Cys Glu Lys Leu 
225                 230                 235                 240 


Thr Val Leu Cys Ser Ala Pro Gly Thr Leu Lys Thr Leu Ala Arg Tyr 
                245                 250                 255     


Ala Val Arg Arg Ser Leu Gly Leu Gln Tyr Leu Pro Asp Ala Val Lys 
            260                 265                 270         


Gly Leu Pro Leu Pro Ala Ser Leu Lys Glu Tyr Leu Leu Leu Leu Glu 
        275                 280                 285             


<210> 5394
<211> 446
<212> PRT
<213> Homo sapiens

<400> 5394
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Thr Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ala Gly Gly Tyr Val Gly Asp Ser Ala Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ser Ser Ser Gln Lys Tyr Val Pro Arg Ala Ala 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Cys Glu His Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Phe Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Arg Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Pro 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Ser Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Phe Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asn Asp 
            420                 425                 430         


Gly Glu Glu Ala Phe Glu Asp Glu Glu Glu Glu Ile Asp Gly 
        435                 440                 445     


<210> 5395
<211> 263
<212> PRT
<213> Homo sapiens

<400> 5395
Met Leu Ser Ser Lys Gly Leu Thr Val Val Asp Val Tyr Gln Gly Trp 
1               5                   10                  15      


Cys Gly Pro Cys Lys Pro Val Val Ser Leu Phe Gln Lys Met Arg Ile 
            20                  25                  30          


Glu Val Gly Leu Asp Leu Leu His Phe Ala Leu Ala Glu Ala Asp Arg 
        35                  40                  45              


Leu Asp Val Leu Glu Lys Tyr Arg Gly Lys Cys Glu Pro Thr Phe Leu 
    50                  55                  60                  


Phe Tyr Ala Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val 
65                  70                  75                  80  


Ser His Gly Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu 
                85                  90                  95      


Arg Thr Cys Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly 
            100                 105                 110         


Lys Thr Asp Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile 
        115                 120                 125             


Leu Thr Asn Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe 
    130                 135                 140                 


Tyr Gln His Lys Ala Gly Glu Glu Ala Phe Glu Lys Leu Val His His 
145                 150                 155                 160 


Met Cys Ser Gly Pro Ser His Leu Leu Ile Leu Thr Arg Thr Glu Gly 
                165                 170                 175     


Phe Glu Asp Val Val Thr Thr Trp Arg Thr Val Met Gly Pro Arg Asp 
            180                 185                 190         


Pro Asn Val Ala Arg Arg Glu Gln Pro Glu Ser Leu Arg Ala Gln Tyr 
        195                 200                 205             


Gly Thr Glu Met Pro Phe Asn Ala Val His Gly Ser Arg Asp Arg Glu 
    210                 215                 220                 


Asp Ala Asp Arg Glu Leu Ala Leu Leu Phe Pro Ser Leu Lys Phe Ser 
225                 230                 235                 240 


Asp Lys Asp Thr Glu Ala Pro Gln Gly Glu Ser Ser Thr Gln Pro Arg 
                245                 250                 255     


Leu Lys Ile Thr Asp Leu Asp 
            260             


<210> 5396
<211> 362
<212> PRT
<213> Homo sapiens

<400> 5396
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Phe Thr Glu Ile Ser His Arg Ile Leu Cys Ser Tyr 
225                 230                 235                 240 


Asn Thr Asn Ile Glu Glu Leu Phe Ala Glu Ile Asp Gln Cys Leu Ala 
                245                 250                 255     


Ile Asn Arg Ser Val Leu Gln Gln Leu Glu Glu Lys Cys Gly His Glu 
            260                 265                 270         


Ile Thr Glu Glu Glu Trp Glu Lys Ile Gln Val Gln Ala Leu Arg Arg 
        275                 280                 285             


Glu Thr His Glu Cys Ser Ile Cys Leu Ala Pro Leu Ser Ala Ala Gly 
    290                 295                 300                 


Gly Gln Arg Val Gly Ala Gly Arg Arg Ser Arg Glu Met Ala Leu Leu 
305                 310                 315                 320 


Ser Cys Ser His Val Phe His His Ala Cys Leu Leu Ala Leu Glu Glu 
                325                 330                 335     


Phe Ser Val Gly Asp Arg Pro Pro Phe His Ala Cys Pro Leu Cys Arg 
            340                 345                 350         


Ser Cys Tyr Gln Lys Lys Ile Leu Glu Cys 
        355                 360         


<210> 5397
<211> 96
<212> PRT
<213> Homo sapiens

<400> 5397
Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
1               5                   10                  15      


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
            20                  25                  30          


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
        35                  40                  45              


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
    50                  55                  60                  


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
65                  70                  75                  80  


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
                85                  90                  95      


<210> 5398
<211> 152
<212> PRT
<213> Homo sapiens

<400> 5398
Met Ala Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu 
1               5                   10                  15      


Ala Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala 
            20                  25                  30          


Arg Tyr Phe His Val Val Ile Ala Gly Pro Gln Asp Ser Pro Phe Glu 
        35                  40                  45              


Gly Gly Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu Glu Tyr Pro Met 
    50                  55                  60                  


Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn Val 
65                  70                  75                  80  


Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys Trp Ser 
                85                  90                  95      


Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu Leu 
            100                 105                 110         


Ser Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Ala Glu Gln 
        115                 120                 125             


Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp Thr 
    130                 135                 140                 


Arg Leu Tyr Ala Met Asn Asn Ile 
145                 150         


<210> 5399
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 5399
Met Tyr Arg Ser Ser Ala Arg Ser Ser Val Ser Ser His Arg Pro Lys 
1               5                   10                  15      


Asp Asp Gly Gly Gly Gly Pro Arg Ser Gly Arg Ser Ser Gly Ser Ser 
            20                  25                  30          


Ser Gly Pro Ala Arg Arg Ser Ser Pro Pro Pro Pro Pro Ser Gly Ser 
        35                  40                  45              


Ser Ser Arg Thr Pro Ala Arg Arg Pro Arg Ser Pro Ser Gly His Arg 
    50                  55                  60                  


Gly Arg Arg Ala Ser Pro Ser Pro Pro Arg Gly Arg Arg Val Ser Pro 
65                  70                  75                  80  


Ser Pro Pro Arg Ala Arg Arg Gly Ser Pro Ser Pro Pro Arg Gly Arg 
                85                  90                  95      


Arg Leu Phe Pro Pro Gly Pro Ala Gly Phe Arg Gly Ser Ser Arg Gly 
            100                 105                 110         


Glu Ser Arg Ala Asp Tyr Ala Arg Asp Gly Arg Gly Asp His Pro Gly 
        115                 120                 125             


Asp Ser Gly Ser Arg Arg Arg Ser Pro Gly Leu Cys Ser Asp Ser Leu 
    130                 135                 140                 


Glu Lys Ser Leu Arg Ile Thr Val Gly Asn Asp His Phe Cys Val Ser 
145                 150                 155                 160 


Thr Pro Glu Arg Arg Arg Leu Ser Asp Arg Leu Gly Ser Pro Val Asp 
                165                 170                 175     


Asn Leu Glu Asp Met Asp Arg Asp Asp Leu Thr Asp Asp Ser Val Phe 
            180                 185                 190         


Thr Arg Ser Ser Gln Cys Ser Arg Gly Leu Glu Arg Tyr Ile Ser Gln 
        195                 200                 205             


Glu Glu Gly Pro Leu Ser Pro Phe Leu Gly Gln Leu Asp Glu Asp Tyr 
    210                 215                 220                 


Arg Thr Lys Glu Thr Phe Leu His Arg Ser Asp Tyr Ser Pro His Ile 
225                 230                 235                 240 


Ser Cys His Asp Glu Leu Leu Arg Gly Thr Glu Arg Asn Arg Glu Lys 
                245                 250                 255     


Leu Lys Gly Tyr Ser Ile Arg Ser Glu Glu Arg Ser Arg Glu Ala Lys 
            260                 265                 270         


Arg Pro Arg Tyr Asp Asp Thr Val Lys Ile Asn Ser Met Gly Gly Asp 
        275                 280                 285             


His Pro Ser Phe Thr Ser Gly Thr Arg Asn Tyr Arg Gln Arg Arg Arg 
    290                 295                 300                 


Ser Pro Ser Pro Arg Phe Leu Asp Pro Glu Phe Arg Glu Leu Asp Leu 
305                 310                 315                 320 


Ala Arg Arg Lys Arg Glu Glu Glu Glu Glu Arg Ser Arg Ser Leu Ser 
                325                 330                 335     


Gln Glu Leu Val Gly Val Asp Gly Gly Gly Thr Gly Cys Ser Ile Pro 
            340                 345                 350         


Gly Leu Ser Gly Val Leu Thr Ala Ser Glu Pro Gly Tyr Ser Leu His 
        355                 360                 365             


Arg Pro Glu Glu Val Ser Val Met Pro Lys Lys Ser Ile Leu Lys Lys 
    370                 375                 380                 


Arg Ile Glu Val Asp Ile Met Glu Pro Ser Met Gln Leu Glu Ser Phe 
385                 390                 395                 400 


Ser Ser Ser Thr Ser Ser Ser Gln Asp His Pro Leu Tyr Ser Gly His 
                405                 410                 415     


Pro Ser Leu Pro Leu Ser Gly Ala Ile Ala Ala Phe Ala Ser Glu Ile 
            420                 425                 430         


Glu Asn Lys Gly Thr Met Val Glu Thr Ala Leu Lys Glu Pro Gln Gly 
        435                 440                 445             


Asn Leu Tyr Gln Trp Gly Pro Leu Pro Gly Ile Pro Lys Asp Asn Ser 
    450                 455                 460                 


Pro Leu Arg Glu Lys Phe Gly Ser Phe Leu Cys His Lys Asp Asn Leu 
465                 470                 475                 480 


Asp Leu Lys Ala Glu Gly Pro Glu Arg His Thr Asp Phe Leu Leu Pro 
                485                 490                 495     


His Glu Arg Ala Ser Gln Asp Gly Ser Gly Phe Ser Arg Ile Leu Ser 
            500                 505                 510         


Met Leu Ala Asp Ser Thr Ser Thr Gln Glu Lys Arg Arg Arg Ser Phe 
        515                 520                 525             


Pro Asp Ile Glu Asp Glu Glu Lys Phe Leu Tyr Gly Asp Glu Glu Glu 
    530                 535                 540                 


Asp Leu Lys Ala Glu Ser Val Pro Lys Pro Leu Gly Ser Ser Glu Ser 
545                 550                 555                 560 


Glu Val Met Arg Gln Lys Ala Ser Ser Leu Pro Ser Ser Ala Pro Ala 
                565                 570                 575     


Val Lys Leu Glu Ser Leu Glu Glu Thr Asn Pro Glu Tyr Ala Lys Ile 
            580                 585                 590         


His Asp Leu Leu Lys Thr Ile Gly Leu Asp Ile Gly Val Ala Glu Ile 
        595                 600                 605             


Ser Gln Leu Ala Ala Arg Thr Gln Glu Arg Leu His Gly Lys Lys Pro 
    610                 615                 620                 


Ser Leu Arg Ser Ser Ala Asp Arg Arg Ser Ser Val Asp Arg Tyr Phe 
625                 630                 635                 640 


Ser Ala Asp His Cys Ser Ser Val Asp His Arg Phe Ser Ala Asp Arg 
                645                 650                 655     


Cys Ser Ser Val Asp His Cys Phe Ser Ala Asp Arg Arg Ser Ser Asp 
            660                 665                 670         


Pro His Arg Leu Glu Ser Arg Glu Ala His His Ser Asn Thr His Ser 
        675                 680                 685             


Pro Glu Val Ser His Pro His Pro Pro Ser Pro Val Asp Pro Tyr Leu 
    690                 695                 700                 


Leu Thr Lys Asn Ser Pro Pro Phe Leu Lys Ser Asp His Pro Val Gly 
705                 710                 715                 720 


His Ile Ser Gly Pro Glu Val Val Gly Ser Gly Phe Gln Ser Ser Val 
                725                 730                 735     


Ala Val Arg Cys Met Leu Pro Ser Ala Pro Ser Ala Pro Ile Arg Leu 
            740                 745                 750         


Pro His Thr Ala Ala Leu Ser Gln Phe His Met Pro Arg Ala Ser Gln 
        755                 760                 765             


Phe Ala Ala Ala Arg Ile Pro Pro Asn Tyr Gln Gly Pro Ala Ile Pro 
    770                 775                 780                 


Pro Ala Ser Phe Asp Ala Tyr Arg His Tyr Met Ala Tyr Ala Ala Ser 
785                 790                 795                 800 


Arg Trp Pro Met Tyr Pro Thr Ser Gln Pro Ser Asn His Pro Val Pro 
                805                 810                 815     


Glu Pro His Arg Ile Met Pro Ile Thr Lys Gln Ala Thr Arg Ser Arg 
            820                 825                 830         


Pro Asn Leu Arg Val Ile Pro Thr Val Thr Pro Asp Lys Pro Lys Gln 
        835                 840                 845             


Lys Glu Ser Leu Arg Gly Ser Ile Pro Ala Ala Gln Val Pro Val Gln 
    850                 855                 860                 


Val Ser Ile Pro Ser Leu Ile Arg Tyr Asn Pro Glu Lys Ile Ser Asp 
865                 870                 875                 880 


Glu Lys Asn Arg Ala Ser Gln Lys Gln Lys Val Ile Glu Glu Arg Glu 
                885                 890                 895     


Lys Leu Lys Asn Asp Arg Glu Ala Arg Gln Lys Lys Met Tyr Tyr Leu 
            900                 905                 910         


Arg Thr Glu Leu Glu Arg Leu His Lys Gln Gln Gly Glu Met Leu Arg 
        915                 920                 925             


Lys Lys Arg Arg Glu Lys Asp Gly His Lys Asp Pro Leu Leu Val Glu 
    930                 935                 940                 


Val Ser Arg Leu Gln Asp Asn Ile Met Lys Asp Ile Ala Glu Leu Arg 
945                 950                 955                 960 


Gln Glu Ala Glu Glu Ala Glu Lys Lys Gln Ser Glu Leu Asp Lys Val 
                965                 970                 975     


Ala Gln Ile Leu Gly Ile Asn Ile Phe Asp Lys Ser Gln Lys Ser Leu 
            980                 985                 990         


Ser Asp Ser Arg Glu Pro Thr Glu  Lys Pro Gly Lys Ala  Glu Lys Ser 
        995                 1000                 1005             


Lys Ser  Pro Glu Lys Val Ser  Ser Phe Ser Asn Ser  Ser Ser Asn 
    1010                 1015                 1020             


Lys Glu  Ser Lys Val Asn Asn  Glu Lys Phe Arg Thr  Lys Ser Pro 
    1025                 1030                 1035             


Lys Pro  Ala Glu Ser Pro Gln  Ser Ala Thr Lys Gln  Leu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Ala Ala Tyr Glu Tyr  Tyr Asp Ala Gly Asn  His Trp Cys 
    1055                 1060                 1065             


Lys Asp  Cys Asn Thr Ile Cys  Gly Thr Met Phe Asp  Phe Phe Thr 
    1070                 1075                 1080             


His Met  His Asn Lys Lys His  Thr Gln Gly Gln Phe  Gln Lys Ser 
    1085                 1090                 1095             


Ser Asp  Phe Gln Lys Glu Gly  Leu Gln Gln Thr Phe  Leu Pro Pro 
    1100                 1105                 1110             


Glu Arg  Gln Gly 
    1115         


<210> 5400
<211> 191
<212> PRT
<213> Homo sapiens

<400> 5400
Met Tyr Val Cys Leu Cys Val Ser Val Ala Lys Val Thr Met Ala Asp 
1               5                   10                  15      


Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp 
            20                  25                  30          


Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg 
        35                  40                  45              


Ile Met Gln Pro Gly Phe Ala Phe Gly Val Gln Gln Leu His Pro Ala 
    50                  55                  60                  


Leu Ile Gln Arg Pro Phe Gly Ile Pro Ala His Tyr Val Tyr Pro Gln 
65                  70                  75                  80  


Ala Phe Val Gln Pro Gly Val Val Ile Pro His Val Gln Pro Thr Ala 
                85                  90                  95      


Ala Ala Ala Ser Thr Thr Pro Tyr Ile Asp Tyr Thr Gly Ala Ala Tyr 
            100                 105                 110         


Ala Gln Tyr Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr 
        115                 120                 125             


Asp Gln Tyr Pro Tyr Ala Ala Ser Pro Ala Ala Ala Gly Tyr Val Thr 
    130                 135                 140                 


Ala Gly Gly Tyr Gly Tyr Ala Val Gln Gln Pro Ile Thr Ala Ala Ala 
145                 150                 155                 160 


Pro Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                165                 170                 175     


Phe Gly Gln Tyr Gln Pro Gln Gln Leu Gln Thr Asp Arg Met Gln 
            180                 185                 190     


<210> 5401
<211> 109
<212> PRT
<213> Homo sapiens

<400> 5401
Met Ala Gly Ala Pro Thr Val Ser Leu Pro Glu Leu Arg Ser Leu Leu 
1               5                   10                  15      


Ala Ser Gly Arg Ala Arg Leu Phe Asp Val Arg Ser Arg Glu Glu Ala 
            20                  25                  30          


Ala Ala Gly Thr Ile Pro Gly Ala Leu Asn Ile Pro Val Ser Glu Leu 
        35                  40                  45              


Glu Ser Ala Leu Gln Met Glu Pro Ala Ala Phe Gln Ala Leu Tyr Ser 
    50                  55                  60                  


Ala Glu Lys Pro Lys Leu Glu Asp Glu His Leu Val Phe Phe Cys Gln 
65                  70                  75                  80  


Met Gly Lys Arg Gly Leu Gln Ala Thr Gln Leu Ala Arg Ser Leu Gly 
                85                  90                  95      


Tyr Thr Gly Tyr Gly Glu Val Trp Leu Leu Ala Gly Arg 
            100                 105                 


<210> 5402
<211> 209
<212> PRT
<213> Homo sapiens

<400> 5402
Met Ala Leu Leu Ala Glu His Leu Leu Lys Pro Leu Pro Ala Asp Lys 
1               5                   10                  15      


Gln Ile Glu Thr Gly Pro Phe Leu Glu Ala Val Ser His Leu Pro Pro 
            20                  25                  30          


Phe Phe Asp Cys Leu Gly Ser Pro Val Phe Thr Pro Ile Lys Ala Asp 
        35                  40                  45              


Ile Ser Gly Asn Ile Thr Lys Ile Lys Ala Val Tyr Asp Thr Asn Pro 
    50                  55                  60                  


Ala Lys Phe Arg Thr Leu Gln Asn Ile Leu Glu Val Glu Lys Glu Met 
65                  70                  75                  80  


Tyr Gly Ala Glu Trp Pro Lys Val Gly Ala Thr Leu Ala Leu Met Trp 
                85                  90                  95      


Leu Lys Arg Gly Leu Arg Phe Ile Gln Val Phe Leu Gln Ser Ile Cys 
            100                 105                 110         


Asp Gly Glu Arg Asp Glu Asn His Pro Asn Leu Ile Arg Val Asn Ala 
        115                 120                 125             


Thr Lys Ala Tyr Glu Met Ala Leu Lys Lys Tyr His Gly Trp Ile Val 
    130                 135                 140                 


Gln Lys Ile Phe Gln Ala Ala Leu Tyr Ala Ala Pro Tyr Lys Ser Asp 
145                 150                 155                 160 


Phe Leu Lys Ala Leu Ser Lys Gly Gln Asn Val Thr Glu Glu Glu Cys 
                165                 170                 175     


Leu Glu Lys Ile Arg Leu Phe Leu Val Asn Tyr Thr Ala Thr Ile Asp 
            180                 185                 190         


Val Ile Tyr Glu Met Tyr Thr Gln Met Asn Ala Glu Leu Asn Tyr Lys 
        195                 200                 205             


Val 
    


<210> 5403
<211> 157
<212> PRT
<213> Homo sapiens

<400> 5403
Met Glu Glu Ala Gln Arg Lys Arg Thr Gln Leu Arg Glu Ala Phe Glu 
1               5                   10                  15      


Gln Leu Gln Ala Lys Lys Gln Met Ala Met Glu Lys Arg Arg Ala Val 
            20                  25                  30          


Gln Asn Gln Trp Gln Leu Gln Gln Glu Lys His Leu Gln His Leu Ala 
        35                  40                  45              


Glu Val Ser Ala Glu Val Arg Glu Arg Lys Thr Gly Thr Gln Gln Glu 
    50                  55                  60                  


Leu Asp Arg Val Phe Gln Lys Leu Gly Asn Leu Lys Gln Gln Ala Glu 
65                  70                  75                  80  


Gln Glu Arg Asp Lys Leu Gln Arg Tyr Gln Thr Phe Leu Gln Leu Leu 
                85                  90                  95      


Tyr Thr Leu Gln Gly Lys Leu Leu Phe Pro Glu Ala Glu Ala Glu Ala 
            100                 105                 110         


Glu Asn Leu Pro Asp Asp Lys Pro Gln Gln Pro Thr Arg Pro Gln Glu 
        115                 120                 125             


Gln Ser Thr Gly Asp Thr Met Gly Arg Asp Pro Gly Val Ser Phe Lys 
    130                 135                 140                 


Ala Val Gly Leu Gln Pro Ala Gly Asp Val Asn Leu Pro 
145                 150                 155         


<210> 5404
<211> 212
<212> PRT
<213> Homo sapiens

<400> 5404
Met Glu Val Leu Arg Arg Ser Ser Val Phe Ala Ala Glu Ile Met Asp 
1               5                   10                  15      


Ala Phe Asp Arg Ser Pro Thr Asp Lys Glu Leu Val Ala Gln Ala Lys 
            20                  25                  30          


Ala Leu Gly Arg Glu Tyr Val His Ala Arg Leu Leu Arg Ala Gly Leu 
        35                  40                  45              


Ser Trp Ser Ala Pro Glu Arg Ala Ala Pro Val Pro Gly Arg Leu Ala 
    50                  55                  60                  


Glu Val Cys Ala Val Leu Leu Arg Leu Gly Asp Glu Leu Glu Met Ile 
65                  70                  75                  80  


Arg Pro Ser Val Tyr Arg Asn Val Ala Arg Gln Leu His Ile Ser Leu 
                85                  90                  95      


Gln Ser Glu Pro Val Val Thr Asp Ala Phe Leu Ala Val Ala Gly His 
            100                 105                 110         


Ile Phe Ser Ala Gly Ile Thr Trp Gly Lys Val Val Ser Leu Tyr Ala 
        115                 120                 125             


Val Ala Ala Gly Leu Ala Val Asp Cys Val Arg Gln Ala Gln Pro Ala 
    130                 135                 140                 


Met Val His Ala Leu Val Asp Cys Leu Gly Glu Phe Val Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Thr Trp Leu Arg Arg Arg Gly Gly Trp Thr Asp Val Leu Lys 
                165                 170                 175     


Cys Val Val Ser Thr Asp Pro Gly Leu Arg Ser His Trp Leu Val Ala 
            180                 185                 190         


Ala Leu Cys Ser Phe Gly Arg Phe Leu Lys Ala Ala Phe Phe Val Leu 
        195                 200                 205             


Leu Pro Glu Arg 
    210         


<210> 5405
<211> 715
<212> PRT
<213> Homo sapiens

<400> 5405
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val Gln 
65                  70                  75                  80  


Leu Ser Ser Lys Glu Lys Ile Trp Thr Gln Glu Met Leu Leu Gln Val 
                85                  90                  95      


Asn Asp Gln Ser Leu Arg Leu Leu Asp Ile Glu Ser Gln Glu Glu Leu 
            100                 105                 110         


Glu Asp Phe Pro Leu Pro Thr Val Gln Arg Ser Gln Thr Val Leu Asn 
        115                 120                 125             


Gln Leu Arg Tyr Pro Ser Val Leu Leu Leu Val Cys Gln Asp Ser Glu 
    130                 135                 140                 


Gln Ser Lys Pro Asp Val His Phe Phe His Cys Asp Glu Val Glu Ala 
145                 150                 155                 160 


Glu Leu Val His Glu Asp Ile Glu Ser Ala Leu Ala Asp Cys Arg Leu 
                165                 170                 175     


Gly Lys Lys Met Arg Pro Gln Thr Leu Lys Gly His Gln Glu Lys Ile 
            180                 185                 190         


Arg Gln Arg Gln Ser Ile Leu Pro Pro Pro Gln Gly Pro Ala Pro Ile 
        195                 200                 205             


Pro Phe Gln His Arg Gly Gly Asp Ser Pro Glu Ala Lys Asn Arg Val 
    210                 215                 220                 


Gly Pro Gln Val Pro Leu Ser Glu Pro Gly Phe Arg Arg Arg Glu Ser 
225                 230                 235                 240 


Gln Glu Glu Pro Arg Ala Val Leu Ala Gln Lys Ile Glu Lys Glu Thr 
                245                 250                 255     


Gln Ile Leu Asn Cys Ala Leu Asp Asp Ile Glu Trp Phe Val Ala Arg 
            260                 265                 270         


Leu Gln Lys Ala Ala Glu Ala Phe Lys Gln Leu Asn Gln Arg Lys Lys 
        275                 280                 285             


Gly Lys Lys Lys Gly Lys Lys Ala Pro Ala Glu Gly Val Leu Thr Leu 
    290                 295                 300                 


Arg Ala Arg Pro Pro Ser Glu Gly Glu Phe Ile Asp Cys Phe Gln Lys 
305                 310                 315                 320 


Ile Lys Leu Ala Ile Asn Leu Leu Ala Lys Leu Gln Lys His Ile Gln 
                325                 330                 335     


Asn Pro Ser Ala Ala Glu Leu Val His Phe Leu Phe Gly Pro Leu Asp 
            340                 345                 350         


Leu Ile Val Asn Thr Cys Ser Gly Pro Asp Ile Ala Arg Ser Val Ser 
        355                 360                 365             


Cys Pro Leu Leu Ser Arg Asp Ala Val Asp Phe Leu Arg Gly His Leu 
    370                 375                 380                 


Val Pro Lys Glu Met Ser Leu Trp Glu Ser Leu Gly Glu Ser Trp Met 
385                 390                 395                 400 


Arg Pro Arg Ser Glu Trp Pro Arg Glu Pro Gln Val Pro Leu Tyr Val 
                405                 410                 415     


Pro Lys Phe His Ser Gly Trp Glu Pro Pro Val Asp Val Leu Gln Glu 
            420                 425                 430         


Ala Pro Trp Glu Val Glu Gly Leu Ala Ser Ala Pro Ile Glu Glu Val 
        435                 440                 445             


Ser Pro Val Ser Arg Gln Ser Ile Arg Asn Ser Gln Lys His Ser Pro 
    450                 455                 460                 


Thr Ser Glu Pro Thr Pro Pro Gly Asp Ala Leu Pro Pro Val Ser Ser 
465                 470                 475                 480 


Pro His Thr His Arg Gly Tyr Gln Pro Thr Pro Ala Met Ala Lys Tyr 
                485                 490                 495     


Val Lys Ile Leu Tyr Asp Phe Thr Ala Arg Asn Ala Asn Glu Leu Ser 
            500                 505                 510         


Val Leu Lys Asp Glu Val Leu Glu Val Leu Glu Asp Gly Arg Gln Trp 
        515                 520                 525             


Trp Lys Leu Arg Ser Arg Ser Gly Gln Ala Gly Tyr Val Pro Cys Asn 
    530                 535                 540                 


Ile Leu Gly Glu Ala Arg Pro Glu Asp Ala Gly Ala Pro Phe Glu Gln 
545                 550                 555                 560 


Ala Gly Gln Lys Tyr Trp Gly Pro Ala Ser Pro Thr His Lys Leu Pro 
                565                 570                 575     


Pro Ser Phe Pro Gly Asn Lys Asp Glu Leu Met Gln His Met Asp Glu 
            580                 585                 590         


Val Asn Asp Glu Leu Ile Arg Lys Ile Ser Asn Ile Arg Ala Gln Pro 
        595                 600                 605             


Gln Arg His Phe Arg Val Glu Arg Ser Gln Pro Val Ser Gln Pro Leu 
    610                 615                 620                 


Thr Tyr Glu Ser Gly Pro Asp Glu Val Arg Ala Trp Leu Glu Ala Lys 
625                 630                 635                 640 


Ala Phe Ser Pro Arg Ile Val Glu Asn Leu Gly Ile Leu Thr Gly Pro 
                645                 650                 655     


Gln Leu Phe Ser Leu Asn Lys Glu Glu Leu Lys Lys Val Cys Gly Glu 
            660                 665                 670         


Glu Gly Val Arg Val Tyr Ser Gln Leu Thr Met Gln Lys Ala Phe Leu 
        675                 680                 685             


Glu Lys Gln Gln Ser Gly Ser Glu Leu Glu Glu Leu Met Asn Lys Phe 
    690                 695                 700                 


His Ser Met Asn Gln Arg Arg Gly Glu Asp Ser 
705                 710                 715 


<210> 5406
<211> 199
<212> PRT
<213> Homo sapiens

<400> 5406
Met Ala Trp Pro Cys Ile Ser Arg Leu Cys Cys Leu Ala Arg Arg Trp 
1               5                   10                  15      


Asn Gln Leu Asp Arg Ser Asp Val Ala Val Pro Leu Thr Leu His Gly 
            20                  25                  30          


Tyr Ser Asp Leu Asp Ser Glu Glu Pro Gly Thr Gly Gly Ala Ala Ser 
        35                  40                  45              


Arg Arg Gly Gln Pro Pro Ala Gly Ala Arg Asp Ser Gly Arg Asp Val 
    50                  55                  60                  


Pro Leu Thr Gln Tyr Gln Arg Asp Phe Gly Leu Trp Thr Thr Pro Ala 
65                  70                  75                  80  


Gly Pro Lys Asp Pro Pro Pro Gly Arg Gly Pro Gly Ala Gly Gly Arg 
                85                  90                  95      


Arg Gly Lys Ser Ser Ala Gln Ser Ser Ala Pro Pro Ala Pro Gly Ala 
            100                 105                 110         


Arg Gly Val Tyr Val Leu Pro Ile Gly Asp Ala Asp Ala Ala Ala Ala 
        115                 120                 125             


Val Thr Thr Ser Tyr Arg Gln Glu Phe Gln Ala Trp Thr Gly Val Lys 
    130                 135                 140                 


Pro Ser Arg Ser Thr Lys Thr Lys Pro Ala Arg Val Ile Thr Thr His 
145                 150                 155                 160 


Thr Ser Gly Trp Asp Ser Ser Pro Gly Ala Gly Phe Gln Val Pro Glu 
                165                 170                 175     


Val Arg Lys Lys Phe Thr Pro Asn Pro Ser Ala Ile Phe Gln Ala Ser 
            180                 185                 190         


Ala Pro Arg Ile Leu Asn Val 
        195                 


<210> 5407
<211> 1701
<212> PRT
<213> Homo sapiens

<400> 5407
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys 
    50                  55                  60                  


Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Pro Thr Cys Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr 
                85                  90                  95      


Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr 
            100                 105                 110         


Glu Asn Gly Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile 
        115                 120                 125             


Thr Ser Arg Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn 
    130                 135                 140                 


Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg 
145                 150                 155                 160 


Val Leu Ile Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu 
                165                 170                 175     


Phe His Asn Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser 
            180                 185                 190         


Glu Pro Val Gln Leu Leu Arg Tyr Ser Pro Thr Leu Ala Ser Glu Thr 
        195                 200                 205             


Ser Pro Val Pro Glu Ala Arg Arg Gly Ser Ser Ala Asp Ser Leu Pro 
    210                 215                 220                 


Ser His Arg Pro Ser Pro Thr Asp Ser Arg Leu Arg Ser Ser Lys Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Ser Glu Ser Ser Trp Tyr Asp Ser Pro Trp Gly Asn 
                245                 250                 255     


Ala Gly Glu Leu Ser Glu Ala Glu Gly Ser Phe Leu Ala Pro Gly Met 
            260                 265                 270         


Pro Asp Pro Ser Leu His Ala Ser Phe Pro Pro Gly Asp Ala Lys Lys 
        275                 280                 285             


Pro Phe Asn Gln Ser Ser Ser Leu Ser Ser Leu Arg Glu Leu Tyr Lys 
    290                 295                 300                 


Asp Ala Asn Leu Gly Ser Leu Ser Pro Ser Gly Ile Arg Leu Ser Asp 
305                 310                 315                 320 


Glu Tyr Met Gly Thr His Ala Ser Leu Ser Asn Arg Val Ser Phe Ala 
                325                 330                 335     


Ser Asp Ile Asp Val Pro Ser Arg Val Ala His Gly Asp Pro Ile Gln 
            340                 345                 350         


Tyr Ser Ser Phe Thr Leu Pro Cys Arg Lys Pro Lys Ala Phe Val Glu 
        355                 360                 365             


Asp Thr Ala Lys Lys Asp Ser Leu Lys Ala Arg Met Arg Arg Ile Ser 
    370                 375                 380                 


Asp Trp Thr Gly Ser Leu Ser Arg Lys Lys Arg Lys Leu Gln Glu Pro 
385                 390                 395                 400 


Arg Ser Lys Glu Gly Ser Asp Tyr Phe Asp Ser Arg Ser Asp Gly Leu 
                405                 410                 415     


Asn Thr Asp Val Gln Gly Ser Ser Gln Ala Ser Ala Phe Leu Trp Ser 
            420                 425                 430         


Gly Gly Ser Thr Gln Ile Leu Ser Gln Arg Ser Glu Ser Thr His Ala 
        435                 440                 445             


Ile Gly Ser Asp Pro Leu Arg Gln Asn Ile Tyr Glu Asn Phe Met Arg 
    450                 455                 460                 


Glu Leu Glu Met Ser Arg Thr Asn Thr Glu Asn Ile Glu Thr Ser Thr 
465                 470                 475                 480 


Glu Thr Ala Glu Ser Ser Ser Glu Ser Leu Ser Ser Leu Glu Gln Leu 
                485                 490                 495     


Asp Leu Leu Phe Glu Lys Glu Gln Gly Val Val Arg Lys Ala Gly Trp 
            500                 505                 510         


Leu Phe Phe Lys Pro Leu Val Thr Val Gln Lys Glu Arg Lys Leu Glu 
        515                 520                 525             


Leu Val Ala Arg Arg Lys Trp Lys Gln Tyr Trp Val Thr Leu Lys Gly 
    530                 535                 540                 


Cys Thr Leu Leu Phe Tyr Glu Thr Tyr Gly Lys Asn Ser Met Asp Gln 
545                 550                 555                 560 


Ser Ser Ala Pro Arg Cys Ala Leu Phe Ala Glu Asp Ser Ile Val Gln 
                565                 570                 575     


Ser Val Pro Glu His Pro Lys Lys Glu Asn Val Phe Cys Leu Ser Asn 
            580                 585                 590         


Ser Phe Gly Asp Val Tyr Leu Phe Gln Ala Thr Ser Gln Thr Asp Leu 
        595                 600                 605             


Glu Asn Trp Val Thr Ala Val His Ser Ala Cys Ala Ser Leu Phe Ala 
    610                 615                 620                 


Lys Lys His Gly Lys Glu Asp Thr Leu Arg Leu Leu Lys Asn Gln Thr 
625                 630                 635                 640 


Lys Asn Leu Leu Gln Lys Ile Asp Met Asp Ser Lys Met Lys Lys Met 
                645                 650                 655     


Ala Glu Leu Gln Leu Ser Val Val Ser Asp Pro Lys Asn Arg Lys Ala 
            660                 665                 670         


Ile Glu Asn Gln Ile Gln Gln Trp Glu Gln Asn Leu Glu Lys Phe His 
        675                 680                 685             


Met Asp Leu Phe Arg Met Arg Cys Tyr Leu Ala Ser Leu Gln Gly Gly 
    690                 695                 700                 


Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala Ala Ala Ser Arg Pro Ser 
705                 710                 715                 720 


Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu Ser Val Ser Ser Phe His 
                725                 730                 735     


Ala Leu Val Cys Ser Arg Asp Asp Ser Ala Leu Arg Lys Arg Thr Leu 
            740                 745                 750         


Ser Leu Thr Gln Arg Gly Arg Asn Lys Lys Gly Ile Phe Ser Ser Leu 
        755                 760                 765             


Lys Gly Leu Asp Thr Leu Ala Arg Lys Gly Lys Glu Lys Arg Pro Ser 
    770                 775                 780                 


Ile Thr Gln Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp 
785                 790                 795                 800 


Gly Val Pro Arg Asp Asn Ala Trp Glu Ile Gln Thr Tyr Val His Phe 
                805                 810                 815     


Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val 
            820                 825                 830         


Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser 
        835                 840                 845             


His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr 
    850                 855                 860                 


Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu 
865                 870                 875                 880 


Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr 
                885                 890                 895     


Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu 
            900                 905                 910         


Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly 
        915                 920                 925             


Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu 
    930                 935                 940                 


Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu 
945                 950                 955                 960 


Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp 
                965                 970                 975     


Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser 
            980                 985                 990         


Arg Asp Gln Lys Ser Leu Leu Pro  Pro Pro Asn Gln Ser  Gln Leu Leu 
        995                 1000                 1005             


Glu Glu  Phe Leu Asp Asn Phe  Lys Lys Asn Thr Ala  Asn Asp Phe 
    1010                 1015                 1020             


Ser Asn  Val Pro Asp Ile Thr  Thr Gly Leu Lys Arg  Ser Gln Thr 
    1025                 1030                 1035             


Asp Gly  Thr Leu Asp Gln Val  Ser His Arg Glu Lys  Met Glu Gln 
    1040                 1045                 1050             


Thr Phe  Arg Ser Ala Glu Gln  Ile Thr Ala Leu Cys  Arg Ser Phe 
    1055                 1060                 1065             


Asn Asp  Ser Gln Ala Asn Gly  Met Glu Gly Pro Arg  Glu Asn Gln 
    1070                 1075                 1080             


Asp Pro  Pro Pro Arg Ser Leu  Ala Arg His Leu Ser  Asp Ala Asp 
    1085                 1090                 1095             


Arg Leu  Arg Lys Val Ile Gln  Glu Leu Val Asp Thr  Glu Lys Ser 
    1100                 1105                 1110             


Tyr Val  Lys Asp Leu Ser Cys  Leu Phe Glu Leu Tyr  Leu Glu Pro 
    1115                 1120                 1125             


Leu Gln  Asn Glu Thr Phe Leu  Thr Gln Asp Glu Met  Glu Ser Leu 
    1130                 1135                 1140             


Phe Gly  Ser Leu Pro Glu Met  Leu Glu Phe Gln Lys  Val Phe Leu 
    1145                 1150                 1155             


Glu Thr  Leu Glu Asp Gly Ile  Ser Ala Ser Ser Asp  Phe Asn Thr 
    1160                 1165                 1170             


Leu Glu  Thr Pro Ser Gln Phe  Arg Lys Leu Leu Phe  Ser Leu Gly 
    1175                 1180                 1185             


Gly Ser  Phe Leu Tyr Tyr Ala  Asp His Phe Lys Leu  Tyr Ser Gly 
    1190                 1195                 1200             


Phe Cys  Ala Asn His Ile Lys  Val Gln Lys Val Leu  Glu Arg Ala 
    1205                 1210                 1215             


Lys Thr  Asp Lys Ala Phe Lys  Ala Phe Leu Asp Ala  Arg Asn Pro 
    1220                 1225                 1230             


Thr Lys  Gln His Ser Ser Thr  Leu Glu Ser Tyr Leu  Ile Lys Pro 
    1235                 1240                 1245             


Val Gln  Arg Val Leu Lys Tyr  Pro Leu Leu Leu Lys  Glu Leu Val 
    1250                 1255                 1260             


Ser Leu  Thr Asp Gln Glu Ser  Glu Glu His Tyr His  Leu Thr Glu 
    1265                 1270                 1275             


Ala Leu  Lys Ala Met Glu Lys  Val Ala Ser His Ile  Asn Glu Met 
    1280                 1285                 1290             


Gln Lys  Ile Tyr Glu Asp Tyr  Gly Thr Val Phe Asp  Gln Leu Val 
    1295                 1300                 1305             


Ala Glu  Gln Ser Gly Thr Glu  Lys Glu Val Thr Glu  Leu Ser Met 
    1310                 1315                 1320             


Gly Glu  Leu Leu Met His Ser  Thr Val Ser Trp Leu  Asn Pro Phe 
    1325                 1330                 1335             


Leu Ser  Leu Gly Lys Ala Arg  Lys Asp Leu Glu Leu  Thr Val Phe 
    1340                 1345                 1350             


Val Phe  Lys Arg Ala Val Ile  Leu Val Tyr Lys Glu  Asn Cys Lys 
    1355                 1360                 1365             


Leu Lys  Lys Lys Leu Pro Ser  Asn Ser Arg Pro Ala  His Asn Ser 
    1370                 1375                 1380             


Thr Asp  Leu Asp Pro Phe Lys  Phe Arg Trp Leu Ile  Pro Ile Ser 
    1385                 1390                 1395             


Ala Leu  Gln Val Arg Leu Gly  Asn Pro Ala Gly Thr  Glu Asn Asn 
    1400                 1405                 1410             


Ser Ile  Trp Glu Leu Ile His  Thr Lys Ser Glu Ile  Glu Gly Arg 
    1415                 1420                 1425             


Pro Glu  Thr Ile Phe Gln Leu  Cys Cys Ser Asp Ser  Glu Ser Lys 
    1430                 1435                 1440             


Thr Asn  Ile Val Lys Val Ile  Arg Ser Ile Leu Arg  Glu Asn Phe 
    1445                 1450                 1455             


Arg Arg  His Ile Lys Cys Glu  Leu Pro Leu Glu Lys  Thr Cys Lys 
    1460                 1465                 1470             


Asp Arg  Leu Val Pro Leu Lys  Asn Arg Val Pro Val  Ser Ala Lys 
    1475                 1480                 1485             


Leu Ala  Ser Ser Arg Ser Leu  Lys Val Leu Lys Asn  Ser Ser Ser 
    1490                 1495                 1500             


Asn Glu  Trp Thr Gly Glu Thr  Gly Lys Gly Thr Leu  Leu Asp Ser 
    1505                 1510                 1515             


Asp Glu  Gly Ser Leu Ser Ser  Gly Thr Gln Ser Ser  Gly Cys Pro 
    1520                 1525                 1530             


Thr Ala  Glu Gly Arg Gln Asp  Ser Lys Ser Thr Ser  Pro Gly Lys 
    1535                 1540                 1545             


Tyr Pro  His Pro Gly Leu Ala  Asp Phe Ala Asp Asn  Leu Ile Lys 
    1550                 1555                 1560             


Glu Ser  Asp Ile Leu Ser Asp  Glu Asp Asp Asp His  Arg Gln Thr 
    1565                 1570                 1575             


Val Lys  Gln Gly Ser Pro Thr  Lys Asp Ile Glu Ile  Gln Phe Gln 
    1580                 1585                 1590             


Arg Leu  Arg Ile Ser Glu Asp  Pro Asp Val His Pro  Glu Ala Glu 
    1595                 1600                 1605             


Gln Gln  Pro Gly Pro Glu Ser  Gly Glu Gly Gln Lys  Gly Gly Glu 
    1610                 1615                 1620             


Gln Pro  Lys Leu Val Arg Gly  His Phe Cys Pro Ile  Lys Arg Lys 
    1625                 1630                 1635             


Ala Asn  Ser Thr Lys Arg Asp  Arg Gly Thr Leu Leu  Lys Ala Gln 
    1640                 1645                 1650             


Ile Arg  His Gln Ser Leu Asp  Ser Gln Ser Glu Asn  Ala Thr Ile 
    1655                 1660                 1665             


Asp Leu  Asn Ser Val Leu Glu  Arg Glu Phe Ser Val  Gln Ser Leu 
    1670                 1675                 1680             


Thr Ser  Val Val Ser Glu Glu  Cys Phe Tyr Glu Thr  Glu Ser His 
    1685                 1690                 1695             


Gly Lys  Ser 
    1700     


<210> 5408
<211> 1058
<212> PRT
<213> Homo sapiens

<400> 5408
Met Asp Leu Gly Pro Leu Asn Ile Cys Glu Glu Met Thr Ile Leu His 
1               5                   10                  15      


Gly Gly Phe Leu Leu Ala Glu Gln Leu Phe His Pro Lys Ala Leu Ala 
            20                  25                  30          


Glu Leu Thr Lys Ser Asp Trp Glu Arg Val Gly Arg Pro Ile Val Glu 
        35                  40                  45              


Ala Leu Arg Glu Ile Ser Ser Ala Ala Ala His Ser Gln Pro Phe Ala 
    50                  55                  60                  


Trp Lys Lys Lys Ala Leu Ile Ile Ile Trp Ala Lys Val Leu Gln Pro 
65                  70                  75                  80  


His Pro Val Thr Pro Ser Asp Thr Glu Thr Arg Trp Gln Glu Asp Leu 
                85                  90                  95      


Phe Phe Ser Val Gly Asn Met Ile Pro Thr Ile Asn His Thr Ile Leu 
            100                 105                 110         


Phe Glu Leu Leu Lys Ser Leu Glu Ala Ser Gly Leu Phe Ile Gln Leu 
        115                 120                 125             


Leu Met Ala Leu Pro Thr Thr Ile Cys His Ala Glu Leu Glu Arg Phe 
    130                 135                 140                 


Leu Glu His Val Thr Val Asp Thr Ser Ala Glu Asp Val Ala Phe Phe 
145                 150                 155                 160 


Leu Asp Val Trp Trp Glu Val Met Lys His Lys Gly His Pro Gln Asp 
                165                 170                 175     


Pro Leu Leu Ser Gln Phe Ser Ala Met Ala His Lys Tyr Leu Pro Ala 
            180                 185                 190         


Leu Asp Glu Phe Pro His Pro Pro Lys Arg Leu Arg Ser Asp Pro Asp 
        195                 200                 205             


Ala Cys Pro Thr Met Pro Leu Leu Ala Met Leu Leu Arg Gly Leu Thr 
    210                 215                 220                 


Gln Ile Gln Ser Arg Ile Leu Gly Pro Gly Arg Lys Cys Cys Ala Leu 
225                 230                 235                 240 


Ala Asn Leu Ala Asp Met Leu Thr Val Phe Ala Leu Thr Glu Asp Asp 
                245                 250                 255     


Pro Gln Glu Val Ser Ala Thr Val Tyr Leu Asp Lys Leu Ala Thr Val 
            260                 265                 270         


Ile Ser Val Trp Asn Ser Asp Thr Gln Asn Pro Tyr His Gln Gln Ala 
        275                 280                 285             


Leu Ala Glu Lys Val Lys Glu Ala Glu Arg Asp Val Ser Leu Thr Ser 
    290                 295                 300                 


Leu Ala Lys Leu Pro Ser Glu Thr Ile Phe Val Gly Cys Glu Phe Leu 
305                 310                 315                 320 


His His Leu Leu Arg Glu Trp Gly Glu Glu Leu Gln Ala Val Leu Arg 
                325                 330                 335     


Ser Ser Gln Gly Thr Ser Tyr Asp Ser Tyr Arg Leu Cys Asp Ser Leu 
            340                 345                 350         


Thr Ser Phe Ser Gln Asn Ala Thr Leu Tyr Leu Asn Arg Thr Ser Leu 
        355                 360                 365             


Ser Lys Glu Asp Arg Gln Val Val Ser Glu Leu Ala Glu Cys Val Arg 
    370                 375                 380                 


Asp Phe Leu Arg Lys Thr Ser Thr Val Leu Lys Asn Arg Ala Leu Glu 
385                 390                 395                 400 


Asp Ile Thr Ala Ser Ile Ala Met Ala Val Ile Gln Gln Lys Met Asp 
                405                 410                 415     


Arg His Met Glu Val Cys Tyr Ile Phe Ala Ser Glu Lys Lys Trp Ala 
            420                 425                 430         


Phe Ser Asp Glu Trp Val Ala Cys Leu Gly Ser Asn Arg Ala Leu Phe 
        435                 440                 445             


Arg Gln Pro Asp Leu Val Leu Arg Leu Leu Glu Thr Val Ile Asp Val 
    450                 455                 460                 


Ser Thr Ala Asp Arg Ala Ile Pro Glu Ser Gln Ile Arg Gln Val Ile 
465                 470                 475                 480 


His Leu Ile Leu Glu Cys Tyr Ala Asp Leu Ser Leu Pro Gly Lys Asn 
                485                 490                 495     


Lys Val Leu Ala Gly Ile Leu Arg Ser Trp Gly Arg Lys Gly Leu Ser 
            500                 505                 510         


Glu Lys Leu Leu Ala Tyr Val Glu Gly Phe Gln Glu Asp Leu Asn Thr 
        515                 520                 525             


Thr Phe Asn Gln Leu Thr Gln Ser Ala Ser Glu Gln Gly Leu Ala Lys 
    530                 535                 540                 


Ala Val Ala Ser Val Ala Arg Leu Val Ile Val His Pro Glu Val Thr 
545                 550                 555                 560 


Val Lys Lys Met Cys Ser Leu Ala Val Val Asn Leu Gly Thr His Lys 
                565                 570                 575     


Phe Leu Ala Gln Ile Leu Thr Ala Phe Pro Ala Leu Arg Phe Val Glu 
            580                 585                 590         


Glu Gln Gly Pro Asn Ser Ser Ala Thr Phe Met Val Ser Cys Leu Lys 
        595                 600                 605             


Glu Thr Val Trp Met Lys Phe Ser Thr Pro Lys Glu Glu Lys Gln Phe 
    610                 615                 620                 


Leu Glu Leu Leu Asn Cys Leu Met Ser Pro Val Lys Pro Gln Gly Ile 
625                 630                 635                 640 


Pro Val Ala Ala Leu Leu Glu Pro Asp Glu Val Leu Lys Glu Phe Val 
                645                 650                 655     


Leu Pro Phe Leu Arg Leu Asp Val Glu Glu Val Asp Leu Ser Leu Arg 
            660                 665                 670         


Ile Phe Ile Gln Thr Leu Glu Ala Asn Ala Cys Arg Glu Glu Tyr Trp 
        675                 680                 685             


Leu Gln Thr Cys Ser Pro Phe Pro Leu Leu Phe Ser Leu Cys Gln Leu 
    690                 695                 700                 


Leu Asp Arg Phe Ser Lys Tyr Trp Gln Leu Pro Lys Glu Lys Arg Cys 
705                 710                 715                 720 


Leu Ser Leu Asp Arg Lys Asp Leu Ala Ile His Ile Leu Glu Leu Leu 
                725                 730                 735     


Cys Glu Ile Val Ser Ala Asn Ala Glu Thr Phe Ser Pro Asp Val Trp 
            740                 745                 750         


Ile Lys Ser Leu Ser Trp Leu His Arg Lys Leu Glu Gln Leu Asp Trp 
        755                 760                 765             


Thr Val Gly Leu Arg Leu Lys Ser Phe Phe Glu Gly His Phe Lys Cys 
    770                 775                 780                 


Glu Val Pro Ala Thr Leu Phe Glu Ile Cys Lys Leu Ser Glu Asp Glu 
785                 790                 795                 800 


Trp Thr Ser Gln Ala His Pro Gly Tyr Gly Ala Gly Thr Gly Leu Leu 
                805                 810                 815     


Ala Trp Met Glu Cys Cys Cys Val Ser Ser Gly Ile Ser Glu Arg Met 
            820                 825                 830         


Leu Ser Leu Leu Val Val Asp Val Gly Asn Pro Glu Glu Val Arg Leu 
        835                 840                 845             


Phe Ser Lys Gly Phe Leu Val Ala Leu Val Gln Val Met Pro Trp Cys 
    850                 855                 860                 


Ser Pro Gln Glu Trp Gln Arg Leu His Gln Leu Thr Arg Arg Leu Leu 
865                 870                 875                 880 


Glu Lys Gln Leu Leu His Val Pro Tyr Ser Leu Glu Tyr Ile Gln Phe 
                885                 890                 895     


Val Pro Leu Leu Asn Leu Lys Pro Phe Ala Gln Glu Leu Gln Leu Ser 
            900                 905                 910         


Val Leu Phe Leu Arg Thr Phe Gln Phe Leu Cys Ser His Ser Cys Arg 
        915                 920                 925             


Asp Trp Leu Pro Leu Glu Gly Trp Asn His Val Val Lys Leu Leu Cys 
    930                 935                 940                 


Gly Ser Leu Thr Arg Leu Leu Asp Ser Val Arg Ala Ile Gln Ala Ala 
945                 950                 955                 960 


Gly Pro Trp Val Gln Gly Pro Glu Gln Asp Leu Thr Gln Glu Ala Leu 
                965                 970                 975     


Phe Val Tyr Thr Gln Val Phe Cys His Ala Leu His Ile Met Ala Met 
            980                 985                 990         


Leu His Pro Glu Val Cys Glu Pro  Leu Tyr Val Leu Ala  Leu Glu Thr 
        995                 1000                 1005             


Leu Thr  Cys Tyr Glu Thr Leu  Ser Lys Thr Asn Pro  Ser Val Ser 
    1010                 1015                 1020             


Ser Leu  Leu Gln Arg Ala His  Glu Gln Arg Phe Leu  Lys Ser Ile 
    1025                 1030                 1035             


Ala Glu  Gly Ile Gly Pro Glu  Glu Arg Arg Gln Thr  Leu Leu Gln 
    1040                 1045                 1050             


Lys Met  Ser Ser Phe 
    1055             


<210> 5409
<211> 88
<212> PRT
<213> Homo sapiens

<400> 5409
Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Val Trp Ala Gly Gly Arg Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gly Arg Gly Leu 
                85              


<210> 5410
<211> 310
<212> PRT
<213> Homo sapiens

<400> 5410
Met Asp Gly Ser Phe Val Gln His Ser Val Arg Val Leu Gln Glu Leu 
1               5                   10                  15      


Asn Lys Gln Arg Glu Lys Gly Gln Tyr Cys Asp Ala Thr Leu Asp Val 
            20                  25                  30          


Gly Gly Leu Val Phe Lys Ala His Trp Ser Val Leu Ala Cys Cys Ser 
        35                  40                  45              


His Phe Phe Gln Ser Leu Tyr Gly Asp Gly Ser Gly Gly Ser Val Val 
    50                  55                  60                  


Leu Pro Ala Gly Phe Ala Glu Ile Phe Gly Leu Leu Leu Asp Phe Phe 
65                  70                  75                  80  


Tyr Thr Gly His Leu Ala Leu Thr Ser Gly Asn Arg Asp Gln Val Leu 
                85                  90                  95      


Leu Ala Ala Arg Glu Leu Arg Val Pro Glu Ala Val Glu Leu Cys Gln 
            100                 105                 110         


Ser Phe Lys Pro Lys Thr Ser Val Gly Gln Ala Ala Gly Gly Gln Ser 
        115                 120                 125             


Gly Leu Gly Pro Pro Ala Ser Gln Asn Val Asn Ser His Val Lys Glu 
    130                 135                 140                 


Pro Ala Gly Leu Glu Glu Glu Glu Val Ser Arg Thr Leu Gly Leu Val 
145                 150                 155                 160 


Pro Arg Asp Gln Glu Pro Arg Gly Ser His Ser Pro Gln Arg Pro Gln 
                165                 170                 175     


Leu His Ser Pro Ala Gln Ser Glu Gly Pro Ser Ser Leu Cys Gly Lys 
            180                 185                 190         


Leu Lys Gln Ala Leu Lys Pro Cys Pro Leu Glu Asp Lys Lys Pro Glu 
        195                 200                 205             


Asp Cys Lys Val Pro Pro Arg Pro Leu Glu Ala Glu Gly Ala Gln Leu 
    210                 215                 220                 


Gln Gly Gly Ser Asn Glu Trp Glu Val Val Val Gln Val Glu Asp Asp 
225                 230                 235                 240 


Gly Asp Gly Asp Tyr Met Ser Glu Pro Glu Ala Val Leu Thr Arg Arg 
                245                 250                 255     


Lys Ser Asn Val Ile Arg Lys Pro Cys Ala Ala Glu Pro Ala Leu Ser 
            260                 265                 270         


Ala Gly Ser Leu Ala Ala Glu Pro Ala Glu Asn Arg Lys Gly Thr Ala 
        275                 280                 285             


Val Pro Val Glu Cys Pro Thr Cys His Lys Lys Phe Leu Ser Lys Tyr 
    290                 295                 300                 


Tyr Leu Lys Val His Asn 
305                 310 


<210> 5411
<211> 199
<212> PRT
<213> Homo sapiens

<400> 5411
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210> 5412
<211> 170
<212> PRT
<213> Homo sapiens

<400> 5412
Met Ser Val Ala Gly Gly Glu Ile Arg Gly Asp Thr Gly Gly Glu Asp 
1               5                   10                  15      


Thr Ala Ala Pro Gly Arg Phe Ser Phe Ser Pro Glu Pro Thr Leu Glu 
            20                  25                  30          


Asp Ile Arg Arg Leu His Ala Glu Phe Ala Ala Glu Arg Asp Trp Glu 
        35                  40                  45              


Gln Phe His Gln Pro Arg Asn Leu Leu Leu Ala Leu Val Gly Glu Val 
    50                  55                  60                  


Gly Glu Leu Ala Glu Leu Phe Gln Trp Lys Thr Asp Gly Glu Pro Gly 
65                  70                  75                  80  


Pro Gln Gly Trp Ser Pro Arg Glu Arg Ala Ala Leu Gln Glu Glu Leu 
                85                  90                  95      


Ser Asp Val Leu Ile Tyr Leu Val Ala Leu Ala Ala Arg Cys Arg Val 
            100                 105                 110         


Asp Leu Pro Leu Ala Val Leu Ser Lys Met Asp Ile Asn Arg Arg Arg 
        115                 120                 125             


Tyr Pro Ala His Leu Ala Arg Ser Ser Ser Arg Lys Tyr Thr Glu Leu 
    130                 135                 140                 


Pro His Gly Ala Ile Ser Glu Asp Gln Ala Val Gly Pro Ala Asp Ile 
145                 150                 155                 160 


Pro Cys Asp Ser Thr Gly Gln Thr Ser Thr 
                165                 170 


<210> 5413
<211> 233
<212> PRT
<213> Homo sapiens

<400> 5413
Met Ser Ala Lys Arg Ala Glu Leu Lys Lys Thr His Leu Ser Lys Asn 
1               5                   10                  15      


Tyr Lys Ala Val Cys Leu Glu Leu Lys Pro Glu Pro Thr Lys Thr Phe 
            20                  25                  30          


Asp Tyr Lys Ala Val Lys Gln Glu Gly Arg Phe Thr Lys Ala Gly Val 
        35                  40                  45              


Thr Gln Asp Leu Lys Asn Glu Leu Arg Glu Val Arg Glu Glu Leu Lys 
    50                  55                  60                  


Glu Lys Met Glu Glu Ile Lys Gln Ile Lys Asp Leu Met Asp Lys Asp 
65                  70                  75                  80  


Phe Asp Lys Leu His Glu Phe Val Glu Ile Met Lys Glu Met Gln Lys 
                85                  90                  95      


Asp Met Asp Glu Lys Met Asp Ile Leu Ile Asn Thr Gln Lys Asn Tyr 
            100                 105                 110         


Lys Leu Pro Leu Arg Arg Ala Pro Lys Glu Gln Gln Glu Leu Arg Leu 
        115                 120                 125             


Met Gly Lys Thr His Arg Glu Pro Gln Leu Arg Pro Lys Lys Met Asp 
    130                 135                 140                 


Gly Ala Ser Gly Val Asn Gly Ala Pro Cys Ala Leu His Lys Lys Thr 
145                 150                 155                 160 


Met Ala Pro Gln Lys Thr Lys Gln Gly Ser Leu Asp Pro Leu His His 
                165                 170                 175     


Cys Gly Thr Cys Cys Glu Lys Cys Leu Leu Cys Ala Leu Lys Asn Asn 
            180                 185                 190         


Tyr Asn Arg Gly Asn Ile Pro Ser Glu Ala Ser Gly Leu Tyr Lys Gly 
        195                 200                 205             


Gly Glu Glu Pro Val Thr Thr Gln Pro Ser Val Gly His Ala Val Pro 
    210                 215                 220                 


Ala Pro Lys Ser Gln Thr Glu Gly Arg 
225                 230             


<210> 5414
<211> 731
<212> PRT
<213> Homo sapiens

<400> 5414
Met Ser Val Thr Leu Thr Ser Val Lys Arg Val Gln Ser Ser Pro Asn 
1               5                   10                  15      


Leu Leu Ala Ala Gly Arg Asp Ser Gln Ser Pro Asp Ser Ala Trp Arg 
            20                  25                  30          


Ser Tyr Asn Asp Gly Asn Gln Glu Thr Leu Asn Gly Asp Ala Thr Tyr 
        35                  40                  45              


Ser Ser Leu Ala Ala Lys Gly Phe Arg Ser Val Arg Pro Asn Leu Gln 
    50                  55                  60                  


Asp Lys Arg Ser Pro Thr Gln Ser Gln Ile Thr Val Asn Gly Asn Ser 
65                  70                  75                  80  


Gly Gly Ala Val Ser Pro Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro 
                85                  90                  95      


Ser Ala Tyr Ser Leu Pro Ala Ser Leu Asn Ser Ser Ile Val Met Gln 
            100                 105                 110         


His Gly Thr Ser Leu Asp Ser Thr Asp Thr Tyr Pro Gln His Ala Gln 
        115                 120                 125             


Ser Leu Asp Gly Thr Thr Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser 
    130                 135                 140                 


Glu Glu Glu Lys Arg Val Thr Val Ile Lys Ala Pro His Tyr Pro Gly 
145                 150                 155                 160 


Ile Gly Pro Val Asp Glu Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr 
                165                 170                 175     


Val Asp Arg Pro Lys Asp Trp Tyr Lys Thr Met Phe Lys Gln Ile His 
            180                 185                 190         


Met Val His Lys Pro Asp Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr 
        195                 200                 205             


Thr Tyr Asn Ala Gly Leu Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His 
    210                 215                 220                 


Pro Ala Ala Lys Thr Gln Thr Tyr Arg Pro Leu Ser Lys Ser His Ser 
225                 230                 235                 240 


Asp Asn Ser Pro Asn Ala Phe Lys Asp Ala Ser Ser Pro Val Pro Pro 
                245                 250                 255     


Pro His Val Pro Pro Pro Val Pro Pro Leu Arg Pro Arg Asp Arg Ser 
            260                 265                 270         


Ser Thr Glu Lys His Asp Trp Asp Pro Pro Asp Arg Lys Val Asp Thr 
        275                 280                 285             


Arg Lys Phe Arg Ser Glu Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly 
    290                 295                 300                 


Lys Ser Ser Ile Leu Gln His Glu Arg Pro Pro Pro Leu Pro Thr Thr 
305                 310                 315                 320 


Pro Thr Pro Val Pro Arg Glu Pro Gly Arg Lys Pro Leu Ser Ser Ser 
                325                 330                 335     


Arg Leu Gly Glu Val Thr Gly Ser Pro Ser Pro Pro Pro Arg Ser Gly 
            340                 345                 350         


Ala Pro Thr Pro Ser Ser Arg Ala Pro Ala Leu Ser Pro Thr Arg Pro 
        355                 360                 365             


Pro Lys Lys Pro Leu Asp Tyr Val Gln Asp His Ser Ser Gly Val Phe 
    370                 375                 380                 


Asn Glu Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu Glu Arg 
385                 390                 395                 400 


Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg Arg Lys 
                405                 410                 415     


Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln Ser Ala 
            420                 425                 430         


Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser Thr Thr 
        435                 440                 445             


Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser Arg Ala 
    450                 455                 460                 


Lys Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp Met 
465                 470                 475                 480 


Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu Lys 
                485                 490                 495     


Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys Glu 
            500                 505                 510         


Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile Asp 
        515                 520                 525             


Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe Pro 
    530                 535                 540                 


Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro Ala 
545                 550                 555                 560 


Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile Ala 
                565                 570                 575     


Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg Lys 
            580                 585                 590         


Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr Glu 
        595                 600                 605             


Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser Tyr 
    610                 615                 620                 


Val Glu Val Val Lys Lys Asn Thr Lys Gly Ala Glu Asp Tyr Pro Asp 
625                 630                 635                 640 


Pro Pro Ile Pro His Ser Tyr Ser Ser Asp Arg Ile His Ser Leu Ser 
                645                 650                 655     


Ser Asn Lys Pro Gln Arg Pro Val Phe Thr His Glu Asn Ile Gln Gly 
            660                 665                 670         


Gly Gly Glu Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn Glu 
        675                 680                 685             


Asp Glu Leu Glu Leu Arg Glu Ser Asp Val Ile Asp Val Met Glu Lys 
    690                 695                 700                 


Cys Asp Asp Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe Phe 
705                 710                 715                 720 


Gly Thr Phe Pro Gly Asn Tyr Val Lys Arg Leu 
                725                 730     


<210> 5415
<211> 322
<212> PRT
<213> Homo sapiens

<400> 5415
Met Thr Leu Glu Ala Ile Arg Tyr Ser Arg Gly Ser Leu Gln Ile Leu 
1               5                   10                  15      


Asp Gln Leu Leu Leu Pro Lys Gln Ser Arg Tyr Glu Ala Val Gly Ser 
            20                  25                  30          


Val His Gln Ala Trp Glu Ala Ile Arg Ala Met Lys Val Arg Gly Ala 
        35                  40                  45              


Pro Ala Ile Ala Leu Val Gly Cys Leu Ser Leu Ala Val Glu Leu Gln 
    50                  55                  60                  


Ala Gly Ala Gly Gly Pro Gly Leu Ala Ala Leu Val Ala Phe Val Arg 
65                  70                  75                  80  


Asp Lys Leu Ser Phe Leu Val Thr Ala Arg Pro Thr Ala Val Asn Met 
                85                  90                  95      


Ala Arg Ala Ala Arg Asp Leu Ala Asp Val Ala Ala Arg Glu Ala Glu 
            100                 105                 110         


Arg Glu Gly Ala Thr Glu Glu Ala Val Arg Glu Arg Arg Glu Thr Glu 
        115                 120                 125             


Leu Cys Glu His Trp Glu Glu His Thr Arg Gln Arg Glu Leu Pro Leu 
    130                 135                 140                 


Arg Gly Pro Leu Gly Gly Thr Val Leu Glu Thr Arg Pro Tyr Asn Gln 
145                 150                 155                 160 


Gly Ala Arg Leu Thr Ala Phe Glu Leu Val Tyr Glu Gln Ile Pro Ala 
                165                 170                 175     


Thr Leu Ile Thr Asp Ser Met Val Ala Ala Ala Met Ala His Arg Gly 
            180                 185                 190         


Val Ser Ala Val Val Val Gly Ala Asp Arg Val Val Ala Asn Gly Asp 
        195                 200                 205             


Thr Ala Asn Lys Val Gly Thr Tyr Gln Leu Ala Ile Val Ala Lys His 
    210                 215                 220                 


His Gly Ile Pro Phe Tyr Val Ala Ala Pro Ser Ser Ser Cys Asp Leu 
225                 230                 235                 240 


Arg Leu Glu Thr Gly Lys Glu Ile Ile Ile Glu Glu Arg Pro Gly Gln 
                245                 250                 255     


Glu Leu Thr Asp Val Asn Gly Val Arg Ile Ala Ala Pro Gly Ile Gly 
            260                 265                 270         


Val Trp Asn Pro Ala Phe Asp Val Thr Pro His Asp Leu Ile Thr Gly 
        275                 280                 285             


Gly Ile Ile Thr Glu Leu Gly Val Phe Ala Pro Glu Glu Leu Arg Thr 
    290                 295                 300                 


Ala Leu Thr Thr Thr Ile Ser Ser Arg Asp Gly Thr Leu Asp Gly Pro 
305                 310                 315                 320 


Gln Met 
        


<210> 5416
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 5416
Met Gly Asn Gln Asp Gly Lys Leu Lys Arg Ser Ala Gly Asp Ala Leu 
1               5                   10                  15      


His Glu Gly Gly Gly Gly Ala Glu Asp Ala Leu Gly Pro Arg Asp Val 
            20                  25                  30          


Glu Ala Thr Lys Lys Gly Ser Gly Gly Lys Lys Ala Leu Gly Lys His 
        35                  40                  45              


Gly Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ser Gly Lys Lys 
    50                  55                  60                  


Lys Ser Lys Ser Asp Ser Arg Ala Ser Val Phe Ser Asn Leu Arg Ile 
65                  70                  75                  80  


Arg Lys Asn Leu Ser Lys Gly Lys Gly Ala Gly Gly Ser Arg Glu Asp 
                85                  90                  95      


Val Leu Asp Ser Gln Ala Leu Gln Thr Gly Glu Leu Asp Ser Ala His 
            100                 105                 110         


Ser Leu Leu Thr Lys Thr Pro Asp Leu Ser Leu Ser Ala Asp Glu Ala 
        115                 120                 125             


Gly Leu Ser Asp Thr Glu Cys Ala Asp Pro Phe Glu Val Thr Gly Pro 
    130                 135                 140                 


Gly Gly Pro Gly Pro Ala Glu Ala Arg Val Gly Gly Arg Pro Ile Ala 
145                 150                 155                 160 


Glu Asp Val Glu Thr Ala Ala Gly Ala Gln Asp Gly Gln Arg Thr Ser 
                165                 170                 175     


Ser Gly Ser Asp Thr Asp Ile Tyr Ser Phe His Ser Ala Thr Glu Gln 
            180                 185                 190         


Glu Asp Leu Leu Ser Asp Ile Gln Gln Ala Ile Arg Leu Gln Gln Gln 
        195                 200                 205             


Gln Gln Gln Gln Leu Gln Leu Gln Leu Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gly Ala Glu Glu Pro Ala Ala Pro Pro Thr Ala Val Ser 
225                 230                 235                 240 


Pro Gln Pro Gly Ala Phe Leu Gly Leu Asp Arg Phe Leu Leu Gly Pro 
                245                 250                 255     


Ser Gly Gly Ala Gly Glu Ala Pro Gly Ser Pro Asp Thr Glu Gln Ala 
            260                 265                 270         


Leu Ser Ala Leu Ser Asp Leu Pro Glu Ser Leu Ala Ala Glu Pro Arg 
        275                 280                 285             


Glu Pro Gln Gln Pro Pro Ser Pro Gly Gly Leu Pro Val Ser Glu Ala 
    290                 295                 300                 


Pro Ser Leu Pro Ala Ala Gln Pro Ala Ala Lys Asp Ser Pro Ser Ser 
305                 310                 315                 320 


Thr Ala Phe Pro Phe Pro Glu Ala Gly Pro Gly Glu Glu Ala Ala Gly 
                325                 330                 335     


Ala Pro Val Arg Gly Ala Gly Asp Thr Asp Glu Glu Gly Glu Glu Asp 
            340                 345                 350         


Ala Phe Glu Asp Ala Pro Arg Gly Ser Pro Gly Glu Glu Trp Ala Pro 
        355                 360                 365             


Glu Val Gly Glu Asp Ala Pro Gln Arg Leu Gly Glu Glu Pro Glu Glu 
    370                 375                 380                 


Glu Ala Gln Gly Pro Asp Ala Pro Ala Ala Ala Ser Leu Pro Gly Ser 
385                 390                 395                 400 


Pro Ala Pro Ser Gln Arg Cys Phe Lys Pro Tyr Pro Leu Ile Thr Pro 
                405                 410                 415     


Cys Tyr Ile Lys Thr Thr Thr Arg Gln Leu Ser Ser Pro Asn His Ser 
            420                 425                 430         


Pro Ser Gln Ser Pro Asn Gln Ser Pro Arg Ile Lys Arg Arg Pro Glu 
        435                 440                 445             


Pro Ser Leu Ser Arg Gly Ser Arg Thr Ala Leu Ala Ser Val Ala Ala 
    450                 455                 460                 


Pro Ala Lys Lys His Arg Ala Asp Gly Gly Leu Ala Ala Gly Leu Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Trp Thr Glu Glu Leu Gly Ala Arg Thr Pro Arg Val 
                485                 490                 495     


Gly Gly Ser Ala His Leu Leu Glu Arg Gly Val Ala Ser Asp Ser Gly 
            500                 505                 510         


Gly Gly Val Ser Pro Ala Leu Ala Ala Lys Ala Ser Gly Ala Pro Ala 
        515                 520                 525             


Ala Ala Asp Gly Phe Gln Asn Val Phe Thr Gly Arg Thr Leu Leu Glu 
    530                 535                 540                 


Lys Leu Phe Ser Gln Gln Glu Asn Gly Pro Pro Glu Glu Ala Glu Lys 
545                 550                 555                 560 


Phe Cys Ser Arg Ile Ile Ala Met Gly Leu Leu Leu Pro Phe Ser Asp 
                565                 570                 575     


Cys Phe Arg Glu Pro Cys Asn Gln Asn Ala Gln Thr Asn Ala Ala Ser 
            580                 585                 590         


Phe Asp Gln Asp Gln Leu Tyr Thr Trp Ala Ala Val Ser Gln Pro Thr 
        595                 600                 605             


His Ser Leu Asp Tyr Ser Glu Gly Gln Phe Pro Arg Arg Val Pro Ser 
    610                 615                 620                 


Met Gly Pro Pro Ser Lys Pro Pro Asp Glu Glu His Arg Leu Glu Asp 
625                 630                 635                 640 


Ala Glu Thr Glu Ser Gln Ser Ala Val Ser Glu Thr Pro Gln Lys Arg 
                645                 650                 655     


Ser Asp Ala Val Gln Lys Glu Val Val Asp Met Lys Ser Glu Gly Gln 
            660                 665                 670         


Ala Thr Val Ile Gln Gln Leu Glu Gln Thr Ile Glu Asp Leu Arg Thr 
        675                 680                 685             


Lys Ile Ala Glu Leu Glu Arg Gln Tyr Pro Ala Leu Asp Thr Glu Val 
    690                 695                 700                 


Ala Ser Gly His Gln Gly Leu Glu Asn Gly Val Thr Ala Ser Gly Asp 
705                 710                 715                 720 


Val Cys Leu Glu Ala Leu Arg Leu Glu Glu Lys Glu Val Arg His His 
                725                 730                 735     


Arg Ile Leu Glu Ala Lys Ser Ile Gln Thr Ser Pro Thr Glu Glu Gly 
            740                 745                 750         


Gly Val Leu Thr Leu Pro Pro Val Asp Gly Leu Pro Gly Arg Pro Pro 
        755                 760                 765             


Cys Pro Pro Gly Ala Glu Ser Gly Pro Gln Thr Lys Phe Cys Ser Glu 
    770                 775                 780                 


Ile Ser Leu Ile Val Ser Pro Arg Arg Ile Ser Val Gln Leu Asp Ser 
785                 790                 795                 800 


His Gln Pro Thr Gln Ser Ile Ser Gln Pro Pro Pro Pro Pro Ser Leu 
                805                 810                 815     


Leu Trp Ser Ala Gly Gln Gly Gln Pro Gly Ser Gln Pro Pro His Ser 
            820                 825                 830         


Ile Ser Thr Glu Phe Gln Thr Ser His Glu His Ser Val Ser Ser Ala 
        835                 840                 845             


Phe Lys Asn Ser Cys Asn Ile Pro Ser Pro Pro Pro Leu Pro Cys Thr 
    850                 855                 860                 


Glu Ser Ser Ser Ser Met Pro Gly Leu Gly Met Val Pro Pro Pro Pro 
865                 870                 875                 880 


Pro Pro Leu Pro Gly Met Thr Val Pro Thr Leu Pro Ser Thr Ala Ile 
                885                 890                 895     


Pro Gln Pro Pro Pro Leu Gln Gly Thr Glu Met Leu Pro Pro Pro Pro 
            900                 905                 910         


Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly 
        915                 920                 925             


Ala Gly Ile Leu Pro Leu Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro 
    930                 935                 940                 


Pro Pro Pro Leu Pro Gly Ala Ala Ile Pro Pro Pro Pro Pro Leu Pro 
945                 950                 955                 960 


Gly Ala Gly Ile Pro Leu Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro 
                965                 970                 975     


Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu 
            980                 985                 990         


Pro Gly Ala Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile 
        995                 1000                 1005             


Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro 
    1010                 1015                 1020             


Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1025                 1030                 1035             


Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro 
    1040                 1045                 1050             


Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro 
    1055                 1060                 1065             


Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala 
    1070                 1075                 1080             


Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro 
    1085                 1090                 1095             


Pro Pro  Pro Leu Pro Gly Val  Gly Ile Pro Pro Pro  Pro Pro Leu 
    1100                 1105                 1110             


Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly 
    1115                 1120                 1125             


Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro 
    1130                 1135                 1140             


Pro Pro  Leu Pro Arg Val Gly  Ile Pro Pro Pro Pro  Pro Leu Pro 
    1145                 1150                 1155             


Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile 
    1160                 1165                 1170             


Pro Pro  Pro Pro Pro Leu Pro  Gly Val Gly Ile Pro  Pro Pro Pro 
    1175                 1180                 1185             


Pro Leu  Pro Gly Val Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1190                 1195                 1200             


Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro Gly Met  Gly Ile Pro 
    1205                 1210                 1215             


Pro Ala  Pro Ala Pro Pro Leu  Pro Pro Pro Gly Thr  Gly Ile Pro 
    1220                 1225                 1230             


Pro Pro  Pro Leu Leu Pro Val  Ser Gly Pro Pro Leu  Leu Pro Gln 
    1235                 1240                 1245             


Val Gly  Ser Ser Thr Leu Pro  Thr Pro Gln Val Cys  Gly Phe Leu 
    1250                 1255                 1260             


Pro Pro  Pro Leu Pro Ser Gly  Leu Phe Gly Leu Gly  Met Asn Gln 
    1265                 1270                 1275             


Asp Lys  Gly Ser Arg Lys Gln  Pro Ile Glu Pro Cys  Arg Pro Met 
    1280                 1285                 1290             


Lys Pro  Leu Tyr Trp Thr Arg  Ile Gln Leu His Ser  Lys Arg Asp 
    1295                 1300                 1305             


Ser Ser  Thr Ser Leu Ile Trp  Glu Lys Ile Glu Glu  Pro Ser Ile 
    1310                 1315                 1320             


Asp Cys  His Glu Phe Glu Glu  Leu Phe Ser Lys Thr  Ala Val Lys 
    1325                 1330                 1335             


Glu Arg  Lys Lys Pro Ile Ser  Asp Thr Ile Ser Lys  Thr Lys Ala 
    1340                 1345                 1350             


Lys Gln  Val Val Lys Leu Leu  Ser Asn Lys Arg Ser  Gln Ala Val 
    1355                 1360                 1365             


Gly Ile  Leu Met Ser Ser Leu  His Leu Asp Met Lys  Asp Ile Gln 
    1370                 1375                 1380             


His Ala  Val Val Asn Leu Asp  Asn Ser Val Val Asp  Leu Glu Thr 
    1385                 1390                 1395             


Leu Gln  Ala Leu Tyr Glu Asn  Arg Ala Gln Ser Asp  Glu Leu Glu 
    1400                 1405                 1410             


Lys Ile  Glu Lys His Gly Arg  Ser Ser Lys Asp Lys  Glu Asn Ala 
    1415                 1420                 1425             


Lys Ser  Leu Asp Lys Pro Glu  Gln Phe Leu Tyr Glu  Leu Ser Leu 
    1430                 1435                 1440             


Ile Pro  Asn Phe Ser Glu Arg  Val Phe Cys Ile Leu  Phe Gln Ser 
    1445                 1450                 1455             


Thr Phe  Ser Glu Ser Ile Cys  Ser Ile Arg Arg Lys  Leu Glu Leu 
    1460                 1465                 1470             


Leu Gln  Lys Leu Cys Glu Thr  Leu Lys Asn Gly Pro  Gly Val Met 
    1475                 1480                 1485             


Gln Val  Leu Gly Leu Val Leu  Ala Phe Gly Asn Tyr  Met Asn Gly 
    1490                 1495                 1500             


Gly Asn  Lys Thr Arg Gly Gln  Ala Asp Gly Phe Gly  Leu Asp Ile 
    1505                 1510                 1515             


Leu Pro  Lys Leu Lys Asp Val  Lys Ser Ser Asp Asn  Ser Arg Ser 
    1520                 1525                 1530             


Leu Leu  Ser Tyr Ile Val Ser  Tyr Tyr Leu Arg Asn  Phe Asp Glu 
    1535                 1540                 1545             


Asp Ala  Gly Lys Glu Gln Cys  Leu Phe Pro Leu Pro  Glu Pro Gln 
    1550                 1555                 1560             


Asp Leu  Phe Gln Ala Ser Gln  Met Lys Phe Glu Asp  Phe Gln Lys 
    1565                 1570                 1575             


Asp Leu  Arg Lys Leu Lys Lys  Asp Leu Lys Ala Cys  Glu Val Glu 
    1580                 1585                 1590             


Ala Gly  Lys Val Tyr Gln Val  Ser Ser Lys Glu His  Met Gln Pro 
    1595                 1600                 1605             


Phe Lys  Glu Asn Met Glu Gln  Phe Ile Ile Gln Ala  Lys Ile Asp 
    1610                 1615                 1620             


Gln Glu  Ala Glu Glu Asn Ser  Leu Thr Glu Thr His  Lys Cys Phe 
    1625                 1630                 1635             


Leu Glu  Thr Thr Ala Tyr Phe  Phe Met Lys Pro Lys  Leu Gly Glu 
    1640                 1645                 1650             


Lys Glu  Val Ser Pro Asn Ala  Phe Phe Ser Ile Trp  His Glu Phe 
    1655                 1660                 1665             


Ser Ser  Asp Phe Lys Asp Phe  Trp Lys Lys Glu Asn  Lys Leu Leu 
    1670                 1675                 1680             


Leu Gln  Glu Arg Val Lys Glu  Ala Glu Glu Val Cys  Arg Gln Lys 
    1685                 1690                 1695             


Lys Gly  Lys Ser Leu Tyr Lys  Ile Lys Pro Arg His  Asp Ser Gly 
    1700                 1705                 1710             


Ile Lys  Ala Lys Ile Ser Met  Lys Thr 
    1715                 1720         


<210> 5417
<211> 1015
<212> PRT
<213> Homo sapiens

<400> 5417
Met Thr Val Ser Gln Lys Gly Gly Pro Gln Pro Thr Pro Ser Pro Ala 
1               5                   10                  15      


Gly Pro Gly Thr Gln Leu Gly Pro Ile Thr Gly Glu Met Asp Glu Ala 
            20                  25                  30          


Asp Ser Ala Phe Leu Lys Phe Lys Gln Thr Ala Asp Asp Ser Leu Ser 
        35                  40                  45              


Leu Thr Ser Pro Asn Thr Glu Ser Ile Phe Val Glu Asp Pro Tyr Thr 
    50                  55                  60                  


Ala Ser Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala 
65                  70                  75                  80  


Glu Ser Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys 
                85                  90                  95      


Arg Glu Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Thr 
            100                 105                 110         


Glu Val His His Val Arg Thr Leu Lys Ile Met Leu Lys Val Tyr Ser 
        115                 120                 125             


Arg Ala Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg 
    130                 135                 140                 


Leu Phe Pro Cys Ala Asp Asp Leu Leu Glu Thr His Ser His Phe Leu 
145                 150                 155                 160 


Ala Arg Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp 
                165                 170                 175     


Arg Asn Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe 
            180                 185                 190         


Ser Gly Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys 
        195                 200                 205             


Ser Gly His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln 
    210                 215                 220                 


Asn Lys Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile 
225                 230                 235                 240 


Val Arg Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Thr Gln Arg 
                245                 250                 255     


Ile Thr Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Thr Glu 
            260                 265                 270         


Ala Gly Thr Glu Asp Tyr Glu Asp Leu Thr Gln Ala Leu Asn Leu Ile 
        275                 280                 285             


Lys Asp Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys 
    290                 295                 300                 


Gly Gln Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser 
305                 310                 315                 320 


Ser Lys Leu Lys Asn Gly Leu Thr Phe Arg Lys Glu Asp Met Leu Gln 
                325                 330                 335     


Arg Gln Leu His Leu Glu Gly Met Leu Cys Trp Lys Thr Thr Ser Gly 
            340                 345                 350         


Arg Leu Lys Asp Ile Leu Ala Ile Leu Leu Thr Asp Val Leu Leu Leu 
        355                 360                 365             


Leu Gln Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys 
    370                 375                 380                 


Pro Pro Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn 
385                 390                 395                 400 


Glu Glu Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu 
                405                 410                 415     


Met Tyr Glu Ile Tyr Thr Ser Ser Lys Glu Asp Arg Asn Ala Trp Met 
            420                 425                 430         


Ala His Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly 
        435                 440                 445             


Pro Phe Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala 
    450                 455                 460                 


Thr Arg Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu 
465                 470                 475                 480 


Ile Ala Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala 
                485                 490                 495     


Glu Met Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg 
            500                 505                 510         


Gly Gly Asp Pro Ser Glu Thr Leu Gln Gly Glu Leu Ile Leu Lys Ser 
        515                 520                 525             


Ala Met Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu 
    530                 535                 540                 


Gly Ser Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Thr Gly Pro 
545                 550                 555                 560 


Pro Arg Arg Ala Glu Thr Phe Ala Gly Tyr Asp Cys Thr Asn Ser Pro 
                565                 570                 575     


Thr Lys Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Thr Asp Pro Arg 
            580                 585                 590         


Pro Arg Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser 
        595                 600                 605             


Asp Ser Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu 
    610                 615                 620                 


Ala Pro Gly Thr Glu Ser Asp Pro Arg Leu Pro Thr Val Leu Glu Ser 
625                 630                 635                 640 


Glu Leu Val Gln Arg Ile Gln Thr Leu Ser Gln Leu Leu Leu Asn Leu 
                645                 650                 655     


Gln Ala Val Ile Ala His Gln Asp Ser Tyr Val Glu Thr Gln Arg Ala 
            660                 665                 670         


Ala Ile Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Thr Arg Gly 
        675                 680                 685             


Asn Leu Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg 
    690                 695                 700                 


Glu Glu Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu 
705                 710                 715                 720 


Gln Gln Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu 
                725                 730                 735     


Arg Ala Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu 
            740                 745                 750         


Arg Glu Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln 
        755                 760                 765             


Ala Tyr Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val 
    770                 775                 780                 


Glu Arg Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln 
785                 790                 795                 800 


Asn Thr Ala Pro Gly Ala Leu Pro Pro Asp Thr Leu Ala Glu Ala Gln 
                805                 810                 815     


Pro Pro Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro 
            820                 825                 830         


Arg Val Ser Met Leu Pro Ser Gly Val Gly Pro Glu Tyr Ala Glu Arg 
        835                 840                 845             


Pro Glu Val Ala Arg Arg Asp Ser Ala Pro Thr Glu Asn Arg Leu Ala 
    850                 855                 860                 


Lys Ser Asp Val Pro Ile Gln Leu Leu Ser Ala Thr Asn Gln Phe Gln 
865                 870                 875                 880 


Arg Gln Ala Ala Val Gln Gln Gln Ile Pro Thr Lys Leu Ala Ala Ser 
                885                 890                 895     


Thr Lys Gly Gly Lys Asp Lys Gly Gly Lys Ser Arg Gly Ser Gln Arg 
            900                 905                 910         


Trp Glu Ser Ser Ala Ser Phe Asp Leu Lys Gln Gln Leu Leu Leu Asn 
        915                 920                 925             


Lys Leu Met Gly Lys Asp Glu Ser Thr Ser Arg Asn Arg Arg Ser Leu 
    930                 935                 940                 


Ser Pro Ile Leu Pro Gly Arg His Ser Pro Ala Pro Pro Pro Asp Pro 
945                 950                 955                 960 


Gly Phe Pro Ala Pro Ser Pro Pro Pro Ala Asp Ser Pro Ser Glu Gly 
                965                 970                 975     


Phe Ser Leu Lys Ala Gly Gly Thr Ala Leu Leu Pro Gly Pro Pro Ala 
            980                 985                 990         


Pro Ser Pro Leu Pro Ala Thr Pro  Leu Ser Ala Lys Glu  Asp Ala Ser 
        995                 1000                 1005             


Lys Glu  Asp Val Ile Phe Phe  
    1010                 1015 


<210> 5418
<211> 847
<212> PRT
<213> Homo sapiens

<400> 5418
Met Glu Ala Leu Gly Pro Gly Gly Asp Arg Ala Ser Pro Ala Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Asp Leu Trp His Leu Ser Met Arg Ala Asp Ser Ala 
            20                  25                  30          


Tyr Ser Ser Phe Ser Ala Ala Ser Gly Gly Pro Glu Pro Arg Thr Gln 
        35                  40                  45              


Ser Pro Gly Thr Asp Leu Leu Pro Tyr Leu Asp Trp Asp Tyr Val Arg 
    50                  55                  60                  


Val Val Trp Gly Gly Pro Gly Pro Ala Pro Pro Asp Ala Ala Leu Cys 
65                  70                  75                  80  


Thr Ser Pro Arg Pro Arg Pro Ala Val Ala Ala Arg Ser Gly Pro Gln 
                85                  90                  95      


Pro Thr Glu Val Pro Gly Thr Pro Gly Pro Leu Asn Arg Gln Ala Thr 
            100                 105                 110         


Pro Leu Leu Tyr Ala Leu Ala Ala Glu Ala Glu Ala Ala Ala Gln Ala 
        115                 120                 125             


Ala Glu Pro Pro Ser Pro Pro Ala Ser Arg Ala Ala Tyr Arg Gln Arg 
    130                 135                 140                 


Leu Gln Gly Ala Gln Arg Arg Val Leu Arg Glu Thr Ser Phe Gln Arg 
145                 150                 155                 160 


Lys Glu Leu Arg Met Ser Leu Pro Ala Arg Leu Arg Pro Thr Val Pro 
                165                 170                 175     


Ala Arg Pro Pro Ala Thr His Pro Arg Ser Ala Ser Leu Ser His Pro 
            180                 185                 190         


Gly Gly Glu Gly Glu Pro Ala Arg Ser Arg Ala Pro Ala Pro Gly Thr 
        195                 200                 205             


Ala Gly Arg Gly Pro Leu Ala Asn Gln Gln Arg Lys Trp Cys Phe Ser 
    210                 215                 220                 


Glu Pro Gly Lys Leu Asp Arg Val Gly Arg Gly Gly Gly Pro Ala Arg 
225                 230                 235                 240 


Glu Cys Leu Gly Glu Ala Cys Ser Ser Ser Gly Leu Pro Gly Pro Glu 
                245                 250                 255     


Pro Leu Glu Phe Gln His Pro Ala Leu Ala Lys Phe Glu Asp His Glu 
            260                 265                 270         


Val Gly Trp Leu Pro Glu Thr Gln Pro Gln Gly Ser Met Asn Leu Asp 
        275                 280                 285             


Ser Gly Ser Leu Lys Leu Gly Asp Ala Phe Arg Pro Ala Ser Arg Ser 
    290                 295                 300                 


Arg Ser Ala Ser Gly Glu Val Leu Gly Ser Trp Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Thr Ile Pro Ile Val Gln Ala Val Pro Gln Gly Ala Glu Thr Pro Arg 
                325                 330                 335     


Pro Leu Phe Gln Thr Lys Leu Ser Arg Phe Leu Pro Gln Lys Glu Ala 
            340                 345                 350         


Ala Val Met Tyr Pro Ala Glu Leu Pro Gln Ser Ser Pro Ala Asp Ser 
        355                 360                 365             


Glu Gln Arg Val Ser Glu Thr Cys Ile Val Pro Ala Trp Leu Pro Ser 
    370                 375                 380                 


Leu Pro Asp Glu Val Phe Leu Glu Glu Ala Pro Leu Val Arg Met Arg 
385                 390                 395                 400 


Ser Pro Pro Asp Pro His Ala Ser Gln Gly Pro Pro Ala Ser Val His 
                405                 410                 415     


Ala Ser Asp Gln Pro Tyr Gly Thr Gly Leu Gly Gln Arg Thr Gly Gln 
            420                 425                 430         


Val Thr Val Pro Thr Glu Tyr Pro Leu His Glu Cys Pro Gly Thr Ala 
        435                 440                 445             


Gly Ala Asp Asp Cys Trp Gln Gly Val Asn Gly Ser Val Gly Ile Ser 
    450                 455                 460                 


Arg Pro Thr Ser His Thr Pro Thr Gly Thr Ala Asn Asp Asn Ile Pro 
465                 470                 475                 480 


Thr Ile Asp Pro Thr Gly Leu Thr Thr Asn Pro Pro Thr Ala Ala Glu 
                485                 490                 495     


Ser Asp Leu Leu Lys Pro Val Pro Ala Asp Ala Leu Gly Leu Ser Gly 
            500                 505                 510         


Asn Asp Thr Pro Gly Pro Ser His Asn Thr Ala Leu Ala Arg Gly Thr 
        515                 520                 525             


Gly Gln Pro Gly Ser Arg Pro Thr Trp Pro Ser Gln Cys Leu Glu Glu 
    530                 535                 540                 


Leu Val Gln Glu Leu Ala Arg Leu Asp Pro Ser Leu Cys Asp Pro Leu 
545                 550                 555                 560 


Ala Ser Gln Pro Ser Pro Glu Pro Pro Leu Gly Leu Leu Asp Gly Leu 
                565                 570                 575     


Ile Pro Leu Ala Glu Val Arg Ala Ala Met Arg Pro Ala Cys Gly Glu 
            580                 585                 590         


Ala Gly Glu Glu Ala Ala Ser Thr Phe Glu Pro Gly Ser Tyr Gln Phe 
        595                 600                 605             


Ser Phe Thr Gln Leu Leu Pro Ala Pro Arg Glu Glu Thr Arg Leu Glu 
    610                 615                 620                 


Asn Pro Ala Thr His Pro Val Leu Asp Gln Pro Cys Gly Gln Gly Leu 
625                 630                 635                 640 


Pro Ala Pro Asn Asn Ser Ile Gln Gly Lys Lys Val Glu Leu Ala Ala 
                645                 650                 655     


Arg Leu Gln Lys Met Leu Gln Asp Leu His Thr Glu Gln Glu Arg Leu 
            660                 665                 670         


Gln Gly Glu Ala Gln Ala Trp Ala Arg Arg Gln Ala Ala Leu Glu Ala 
        675                 680                 685             


Ala Val Arg Gln Ala Cys Ala Pro Gln Glu Leu Glu Arg Phe Ser Arg 
    690                 695                 700                 


Phe Met Ala Asp Leu Glu Arg Val Leu Gly Leu Leu Leu Leu Leu Gly 
705                 710                 715                 720 


Ser Arg Leu Ala Arg Val Arg Arg Ala Leu Ala Arg Ala Ala Ser Asp 
                725                 730                 735     


Ser Asp Pro Asp Glu Gln Arg Leu Arg Leu Leu Gln Arg Gln Glu Glu 
            740                 745                 750         


Asp Ala Lys Glu Leu Lys Glu His Val Ala Arg Arg Glu Arg Ala Val 
        755                 760                 765             


Arg Glu Val Leu Val Arg Ala Leu Pro Val Glu Glu Leu Arg Val Tyr 
    770                 775                 780                 


Cys Ala Leu Leu Ala Gly Lys Ala Ala Val Leu Ala Gln Gln Arg Asn 
785                 790                 795                 800 


Leu Asp Glu Arg Ile Arg Leu Leu Gln Asp Gln Leu Asp Ala Ile Arg 
                805                 810                 815     


Asp Asp Leu Gly His His Ala Pro Ser Pro Ser Pro Ala Arg Pro Pro 
            820                 825                 830         


Gly Thr Cys Pro Pro Val Gln Pro Pro Phe Pro Leu Leu Leu Thr 
        835                 840                 845         


<210> 5419
<211> 833
<212> PRT
<213> Homo sapiens

<400> 5419
Met Lys Phe Thr Asn Thr Lys Val Gln Met Met Gln Asn Val His Leu 
1               5                   10                  15      


Ala Pro Glu Thr Asp Glu Asp Asp Leu Tyr Ser Gly Tyr Asn Asp Tyr 
            20                  25                  30          


Asn Pro Ile Tyr Asp Ile Glu Glu Leu Glu Asn Asp Ala Ala Phe Gln 
        35                  40                  45              


Gln Ala Val Arg Thr Ser His Gly Arg Arg Pro Pro Ile Thr Ala Lys 
    50                  55                  60                  


Ile Ser Ser Thr Ala Val Thr Arg Pro Ile Ala Thr Gly Tyr Gly Ser 
65                  70                  75                  80  


Lys Thr Ser Leu Ala Ser Ser Ile Gly Arg Pro Met Thr Gly Ala Ile 
                85                  90                  95      


Gln Asp Gly Val Thr Arg Pro Met Thr Ala Val Arg Ala Ala Gly Phe 
            100                 105                 110         


Thr Lys Ala Ala Leu Arg Gly Ser Ala Phe Asp Pro Leu Ser Gln Ser 
        115                 120                 125             


Arg Gly Pro Ala Ser Pro Leu Glu Ala Lys Lys Lys Asp Ser Pro Glu 
    130                 135                 140                 


Glu Lys Ile Lys Gln Leu Glu Lys Glu Val Asn Glu Leu Val Glu Glu 
145                 150                 155                 160 


Ser Cys Ile Ala Asn Ser Cys Gly Asp Leu Lys Leu Ala Leu Glu Lys 
                165                 170                 175     


Ala Lys Asp Ala Gly Arg Lys Glu Arg Val Leu Val Arg Gln Arg Glu 
            180                 185                 190         


Gln Val Thr Thr Pro Glu Asn Ile Asn Leu Asp Leu Thr Tyr Ser Val 
        195                 200                 205             


Leu Phe Asn Leu Ala Ser Gln Tyr Ser Val Asn Glu Met Tyr Ala Glu 
    210                 215                 220                 


Ala Leu Asn Thr Tyr Gln Val Ile Val Lys Asn Lys Met Phe Ser Asn 
225                 230                 235                 240 


Ala Gly Ile Leu Lys Met Asn Met Gly Asn Ile Tyr Leu Lys Gln Arg 
                245                 250                 255     


Asn Tyr Ser Lys Ala Ile Lys Phe Tyr Arg Met Ala Leu Asp Gln Val 
            260                 265                 270         


Pro Ser Val Asn Lys Gln Met Arg Ile Lys Ile Met Gln Asn Ile Gly 
        275                 280                 285             


Val Thr Phe Ile Gln Ala Gly Gln Tyr Ser Asp Ala Ile Asn Ser Tyr 
    290                 295                 300                 


Glu His Ile Met Ser Met Ala Pro Asn Leu Lys Ala Gly Tyr Asn Leu 
305                 310                 315                 320 


Thr Ile Cys Tyr Phe Ala Ile Gly Asp Arg Glu Lys Met Lys Lys Ala 
                325                 330                 335     


Phe Gln Lys Leu Ile Thr Val Pro Leu Glu Ile Asp Glu Asp Lys Tyr 
            340                 345                 350         


Ile Ser Pro Ser Asp Asp Pro His Thr Asn Leu Val Thr Glu Ala Ile 
        355                 360                 365             


Lys Asn Asp His Leu Arg Gln Met Glu Arg Glu Arg Lys Ala Met Ala 
    370                 375                 380                 


Glu Lys Tyr Ile Met Thr Ser Ala Lys Leu Ile Ala Pro Val Ile Glu 
385                 390                 395                 400 


Thr Ser Phe Ala Ala Gly Tyr Asp Trp Cys Val Glu Val Val Lys Ala 
                405                 410                 415     


Ser Gln Tyr Val Glu Leu Ala Asn Asp Leu Glu Ile Asn Lys Ala Val 
            420                 425                 430         


Thr Tyr Leu Arg Gln Lys Asp Tyr Asn Gln Ala Val Glu Ile Leu Lys 
        435                 440                 445             


Val Leu Glu Lys Lys Asp Ser Arg Val Lys Ser Ala Ala Ala Thr Asn 
    450                 455                 460                 


Leu Ser Ala Leu Tyr Tyr Met Gly Lys Asp Phe Ala Gln Ala Ser Ser 
465                 470                 475                 480 


Tyr Ala Asp Ile Ala Val Asn Ser Asp Arg Tyr Asn Pro Ala Ala Leu 
                485                 490                 495     


Thr Asn Lys Gly Asn Thr Val Phe Ala Asn Gly Asp Tyr Glu Lys Ala 
            500                 505                 510         


Ala Glu Phe Tyr Lys Glu Ala Leu Arg Asn Asp Ser Ser Cys Thr Glu 
        515                 520                 525             


Ala Leu Tyr Asn Ile Gly Leu Thr Tyr Glu Lys Leu Asn Arg Leu Asp 
    530                 535                 540                 


Glu Ala Leu Asp Cys Phe Leu Lys Leu His Ala Ile Leu Arg Asn Ser 
545                 550                 555                 560 


Ala Glu Val Leu Tyr Gln Ile Ala Asn Ile Tyr Glu Leu Met Glu Asn 
                565                 570                 575     


Pro Ser Gln Ala Ile Glu Trp Leu Met Gln Val Val Ser Val Ile Pro 
            580                 585                 590         


Thr Asp Pro Gln Val Leu Ser Lys Leu Gly Glu Leu Tyr Asp Arg Glu 
        595                 600                 605             


Gly Asp Lys Ser Gln Ala Phe Gln Tyr Tyr Tyr Glu Ser Tyr Arg Tyr 
    610                 615                 620                 


Phe Pro Cys Asn Ile Glu Val Ile Glu Trp Leu Gly Ala Tyr Tyr Ile 
625                 630                 635                 640 


Asp Thr Gln Phe Trp Glu Lys Ala Ile Gln Tyr Phe Glu Arg Ala Ser 
                645                 650                 655     


Leu Ile Gln Pro Thr Gln Val Lys Trp Gln Leu Met Val Ala Ser Cys 
            660                 665                 670         


Phe Arg Arg Ser Gly Asn Tyr Gln Lys Ala Leu Asp Thr Tyr Lys Asp 
        675                 680                 685             


Thr His Arg Lys Phe Pro Glu Asn Val Glu Cys Leu Arg Phe Leu Val 
    690                 695                 700                 


Arg Leu Cys Thr Asp Leu Gly Leu Lys Asp Ala Gln Glu Tyr Ala Arg 
705                 710                 715                 720 


Lys Leu Lys Arg Leu Glu Lys Met Lys Glu Ile Arg Glu Gln Arg Ile 
                725                 730                 735     


Lys Ser Gly Arg Asp Gly Ser Gly Gly Ser Arg Gly Lys Arg Glu Gly 
            740                 745                 750         


Ser Ala Ser Gly Asp Ser Gly Gln Asn Tyr Ser Ala Ser Ser Lys Gly 
        755                 760                 765             


Glu Arg Leu Ser Ala Arg Leu Arg Ala Leu Pro Gly Thr Asn Glu Pro 
    770                 775                 780                 


Tyr Glu Ser Ser Ser Asn Lys Glu Ile Asp Ala Ser Tyr Val Asp Pro 
785                 790                 795                 800 


Leu Gly Pro Gln Ile Glu Arg Pro Lys Thr Ala Ala Lys Lys Arg Ile 
                805                 810                 815     


Asp Glu Asp Asp Phe Ala Asp Glu Glu Leu Gly Asp Asp Leu Leu Pro 
            820                 825                 830         


Glu 
    


<210> 5420
<211> 305
<212> PRT
<213> Homo sapiens

<400> 5420
Met Asp Leu Ser Gly Val Lys Lys Lys Ser Leu Leu Gly Val Lys Glu 
1               5                   10                  15      


Asn Asn Lys Lys Ser Ser Thr Arg Ala Pro Ser Pro Thr Lys Arg Lys 
            20                  25                  30          


Asp Arg Ser Asp Glu Lys Ser Lys Asp Arg Ser Lys Asp Lys Gly Ala 
        35                  40                  45              


Thr Lys Glu Ser Ser Glu Lys Asp Arg Gly Arg Asp Lys Thr Arg Lys 
    50                  55                  60                  


Arg Arg Ser Ala Ser Ser Gly Ser Ser Ser Thr Arg Ser Arg Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Gly Ser Ser Thr Ser Thr Gly Ser Ser Ser Gly 
                85                  90                  95      


Ser Ser Ser Ser Ser Ala Ser Ser Arg Ser Gly Ser Ser Ser Thr Ser 
            100                 105                 110         


Arg Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Pro Ser Pro Ser Arg 
        115                 120                 125             


Arg Arg His Asp Asn Arg Arg Arg Ser Arg Ser Lys Ser Lys Pro Pro 
    130                 135                 140                 


Lys Arg Asp Glu Lys Glu Arg Lys Arg Arg Ser Pro Ser Pro Lys Pro 
145                 150                 155                 160 


Thr Lys Val His Ile Gly Arg Leu Thr Arg Asn Val Thr Lys Asp His 
                165                 170                 175     


Ile Met Glu Ile Phe Ser Thr Tyr Gly Lys Ile Lys Met Ile Asp Met 
            180                 185                 190         


Pro Val Glu Arg Met His Pro His Leu Ser Lys Gly Tyr Ala Tyr Val 
        195                 200                 205             


Glu Phe Glu Asn Pro Asp Glu Ala Glu Lys Ala Leu Lys His Met Asp 
    210                 215                 220                 


Gly Gly Gln Ile Asp Gly Gln Glu Ile Thr Ala Thr Ala Val Leu Ala 
225                 230                 235                 240 


Pro Trp Pro Arg Pro Pro Pro Arg Arg Phe Ser Pro Pro Arg Arg Met 
                245                 250                 255     


Leu Pro Pro Pro Pro Met Trp Arg Arg Ser Pro Pro Arg Met Arg Arg 
            260                 265                 270         


Arg Ser Arg Ser Pro Arg Arg Arg Ser Pro Val Arg Arg Arg Ser Arg 
        275                 280                 285             


Ser Pro Gly Arg Arg Arg His Arg Ser Arg Ser Ser Ser Asn Ser Ser 
    290                 295                 300                 


Arg 
305 


<210> 5421
<211> 372
<212> PRT
<213> Homo sapiens

<400> 5421
Met Asp Val Leu Ser Pro Leu Ser Phe Ile Lys Val Ser His Val Arg 
1               5                   10                  15      


Met Gln Gly Ile Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro 
            20                  25                  30          


Tyr Ile Gln Ile Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly 
        35                  40                  45              


Tyr Trp Gly Asn Lys Gly Gly Val Asn Ile Cys Leu Lys Leu Tyr Gly 
    50                  55                  60                  


Tyr Tyr Val Ser Ile Ile Asn Cys His Leu Pro Pro His Ile Ser Asn 
65                  70                  75                  80  


Asn Tyr Gln Arg Leu Glu His Phe Asp Arg Ile Leu Glu Met Gln Asn 
                85                  90                  95      


Cys Glu Gly Arg Asp Ile Pro Asn Ile Leu Asp His Asp Leu Ile Ile 
            100                 105                 110         


Trp Phe Gly Asp Met Asn Phe Arg Ile Glu Asp Phe Gly Leu His Phe 
        115                 120                 125             


Val Arg Glu Ser Ile Lys Asn Arg Cys Tyr Gly Gly Leu Trp Glu Lys 
    130                 135                 140                 


Asp Gln Leu Ser Ile Ala Lys Lys His Asp Pro Leu Leu Arg Glu Phe 
145                 150                 155                 160 


Gln Glu Gly Arg Leu Leu Phe Pro Pro Thr Tyr Lys Phe Asp Arg Asn 
                165                 170                 175     


Ser Asn Asp Tyr Asp Thr Ser Glu Lys Lys Arg Lys Pro Ala Trp Thr 
            180                 185                 190         


Asp Arg Ile Leu Trp Arg Leu Lys Arg Gln Pro Cys Ala Gly Pro Asp 
        195                 200                 205             


Thr Pro Ile Pro Pro Ala Ser His Phe Ser Leu Ser Leu Arg Gly Tyr 
    210                 215                 220                 


Ser Ser His Met Thr Tyr Gly Ile Ser Asp His Lys Pro Val Ser Gly 
225                 230                 235                 240 


Thr Phe Asp Leu Glu Leu Lys Pro Leu Val Ser Ala Pro Leu Ile Val 
                245                 250                 255     


Leu Met Pro Glu Asp Leu Trp Thr Val Glu Asn Asp Met Met Val Ser 
            260                 265                 270         


Tyr Ser Ser Thr Ser Asp Phe Pro Ser Ser Pro Trp Asp Trp Ile Gly 
        275                 280                 285             


Leu Tyr Lys Val Gly Leu Arg Asp Val Asn Asp Tyr Val Ser Tyr Ala 
    290                 295                 300                 


Trp Val Gly Asp Ser Lys Val Ser Cys Ser Asp Asn Leu Asn Gln Val 
305                 310                 315                 320 


Tyr Ile Asp Ile Ser Asn Ile Pro Thr Thr Glu Asp Glu Phe Leu Leu 
                325                 330                 335     


Cys Tyr Tyr Ser Asn Ser Leu Arg Ser Val Val Gly Ile Ser Arg Pro 
            340                 345                 350         


Phe Gln Ile Pro Pro Gly Ser Leu Arg Glu Asp Pro Leu Gly Glu Ala 
        355                 360                 365             


Gln Pro Gln Ile 
    370         


<210> 5422
<211> 563
<212> PRT
<213> Homo sapiens

<400> 5422
Met Arg Leu Asp Leu Ala Ser Leu Met Ser Ala Pro Lys Ser Leu Gly 
1               5                   10                  15      


Ser Ala Phe Lys Ser Trp Arg Leu Asp Lys Ala Pro Ser Pro Gln His 
            20                  25                  30          


Thr Phe Pro Ser Thr Ser Ile Pro Gly Met Ala Phe Ala Leu Leu Ala 
        35                  40                  45              


Ser Val Pro Pro Val Phe Gly Leu Tyr Thr Ser Phe Phe Pro Val Leu 
    50                  55                  60                  


Ile Tyr Ser Leu Leu Gly Thr Gly Arg His Leu Ser Thr Gly Thr Phe 
65                  70                  75                  80  


Ala Ile Leu Ser Leu Met Thr Gly Ser Ala Val Glu Arg Leu Val Pro 
                85                  90                  95      


Glu Pro Leu Val Gly Asn Leu Ser Gly Ile Glu Lys Glu Gln Leu Asp 
            100                 105                 110         


Ala Gln Arg Val Gly Val Ala Ala Ala Val Ala Phe Gly Ser Gly Ala 
        115                 120                 125             


Leu Met Leu Gly Met Phe Val Leu Gln Leu Gly Val Leu Ser Thr Phe 
    130                 135                 140                 


Leu Ser Glu Pro Val Val Lys Ala Leu Thr Ser Gly Ala Ala Leu His 
145                 150                 155                 160 


Val Leu Leu Ser Gln Leu Pro Ser Leu Leu Gly Leu Ser Leu Pro Arg 
                165                 170                 175     


Gln Ile Gly Cys Phe Ser Leu Phe Lys Thr Leu Ala Ser Leu Leu Thr 
            180                 185                 190         


Ala Leu Pro Arg Ser Ser Pro Ala Glu Leu Thr Ile Ser Ala Leu Ser 
        195                 200                 205             


Leu Ala Leu Leu Val Pro Val Lys Glu Leu Asn Val Arg Phe Arg Asp 
    210                 215                 220                 


Arg Leu Pro Thr Pro Ile Pro Gly Glu Val Val Leu Val Leu Leu Ala 
225                 230                 235                 240 


Ser Val Leu Cys Phe Thr Ser Ser Val Asp Thr Arg Tyr Gln Val Gln 
                245                 250                 255     


Ile Val Gly Leu Leu Pro Gly Gly Phe Pro Gln Pro Leu Leu Pro Asn 
            260                 265                 270         


Leu Ala Glu Leu Pro Arg Ile Leu Ala Asp Ser Leu Pro Ile Ala Leu 
        275                 280                 285             


Val Ser Phe Ala Val Ser Ala Ser Leu Ala Ser Ile His Ala Asp Lys 
    290                 295                 300                 


Tyr Ser Tyr Thr Ile Asp Ser Asn Gln Glu Phe Leu Ala His Gly Ala 
305                 310                 315                 320 


Ser Asn Leu Ile Ser Ser Leu Phe Ser Cys Phe Pro Asn Ser Ala Thr 
                325                 330                 335     


Leu Ala Thr Thr Asn Leu Leu Val Asp Ala Gly Gly Lys Thr Gln Leu 
            340                 345                 350         


Ala Gly Leu Phe Ser Cys Thr Val Val Leu Ser Val Leu Leu Trp Leu 
        355                 360                 365             


Gly Pro Phe Phe Tyr Tyr Leu Pro Lys Ala Val Leu Ala Cys Ile Asn 
    370                 375                 380                 


Ile Ser Ser Met Arg Gln Val Phe Cys Gln Met Gln Glu Leu Pro Gln 
385                 390                 395                 400 


Leu Trp His Ile Ser Arg Val Asp Phe Leu Leu Gln Val Pro Gly Leu 
                405                 410                 415     


Cys Ile Leu Ser Tyr Pro Thr Pro Leu Tyr Phe Gly Thr Arg Gly Gln 
            420                 425                 430         


Phe Arg Cys Asn Leu Glu Trp His Leu Gly Leu Gly Glu Gly Glu Lys 
        435                 440                 445             


Glu Thr Ser Lys Pro Asp Gly Pro Met Val Ala Val Ala Glu Pro Val 
    450                 455                 460                 


Arg Val Val Val Leu Asp Phe Ser Gly Val Thr Phe Ala Asp Ala Ala 
465                 470                 475                 480 


Gly Ala Arg Glu Val Val Gln Val Arg Glu Arg Leu Ala Ser Arg Cys 
                485                 490                 495     


Arg Asp Ala Arg Ile Arg Leu Leu Leu Ala Gln Cys Asn Ala Leu Val 
            500                 505                 510         


Gln Gly Thr Leu Thr Arg Val Gly Leu Leu Asp Arg Val Thr Pro Asp 
        515                 520                 525             


Gln Leu Phe Val Ser Val Gln Asp Ala Ala Ala Tyr Ala Leu Gly Ser 
    530                 535                 540                 


Leu Leu Arg Gly Ser Ser Thr Arg Ser Gly Ser Gln Glu Ala Leu Gly 
545                 550                 555                 560 


Cys Gly Lys 
            


<210> 5423
<211> 963
<212> PRT
<213> Homo sapiens

<400> 5423
Met Ala Glu Arg Gly Gly Ala Gly Gly Gly Pro Gly Gly Ala Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gln Arg Gly Ser Gly Val Ala Gln Ser Pro Gln Gln Pro 
            20                  25                  30          


Pro Pro Gln Gln Gln Gln Gln Gln Pro Pro Gln Gln Pro Thr Pro Pro 
        35                  40                  45              


Lys Leu Ala Gln Ala Thr Ser Ser Ser Ser Ser Thr Ser Ala Ala Ala 
    50                  55                  60                  


Ala Ser Ser Ser Ser Ser Ser Thr Ser Thr Ser Met Ala Val Ala Val 
65                  70                  75                  80  


Ala Ser Gly Ser Ala Pro Pro Gly Gly Pro Gly Pro Gly Arg Thr Pro 
                85                  90                  95      


Ala Pro Val Gln Met Asn Leu Tyr Ala Thr Trp Glu Val Asp Arg Ser 
            100                 105                 110         


Ser Ser Ser Cys Val Pro Arg Leu Phe Ser Leu Thr Leu Lys Lys Leu 
        115                 120                 125             


Val Met Leu Lys Glu Met Asp Lys Asp Leu Asn Ser Val Val Ile Ala 
    130                 135                 140                 


Val Lys Leu Gln Gly Ser Lys Arg Ile Leu Arg Ser Asn Glu Ile Val 
145                 150                 155                 160 


Leu Pro Ala Ser Gly Leu Val Glu Thr Glu Leu Gln Leu Thr Phe Ser 
                165                 170                 175     


Leu Gln Tyr Pro His Phe Leu Lys Arg Asp Ala Asn Lys Leu Gln Ile 
            180                 185                 190         


Met Leu Gln Arg Arg Lys Arg Tyr Lys Asn Arg Thr Ile Leu Gly Tyr 
        195                 200                 205             


Lys Thr Leu Ala Val Gly Leu Ile Asn Met Ala Glu Val Met Gln His 
    210                 215                 220                 


Pro Asn Glu Gly Ala Leu Val Leu Gly Leu His Ser Asn Val Lys Asp 
225                 230                 235                 240 


Val Ser Val Pro Val Ala Glu Ile Lys Ile Tyr Ser Leu Ser Ser Gln 
                245                 250                 255     


Pro Ile Asp His Glu Gly Ile Lys Ser Lys Leu Ser Asp Arg Ser Pro 
            260                 265                 270         


Asp Ile Asp Asn Tyr Ser Glu Glu Glu Glu Glu Ser Phe Ser Ser Glu 
        275                 280                 285             


Gln Glu Gly Ser Asp Asp Pro Leu His Gly Gln Asp Leu Phe Tyr Glu 
    290                 295                 300                 


Asp Glu Asp Leu Arg Lys Val Lys Lys Thr Arg Arg Lys Leu Thr Ser 
305                 310                 315                 320 


Thr Ser Ala Ile Thr Arg Gln Pro Asn Ile Lys Gln Lys Phe Val Ala 
                325                 330                 335     


Leu Leu Lys Arg Phe Lys Val Ser Asp Glu Val Gly Phe Gly Leu Glu 
            340                 345                 350         


His Val Ser Arg Glu Gln Ile Arg Glu Val Glu Glu Asp Leu Asp Glu 
        355                 360                 365             


Leu Tyr Asp Ser Leu Glu Met Tyr Asn Pro Ser Asp Ser Gly Pro Glu 
    370                 375                 380                 


Met Glu Glu Thr Glu Ser Ile Leu Ser Thr Pro Lys Pro Lys Leu Lys 
385                 390                 395                 400 


Pro Phe Phe Glu Gly Met Ser Gln Ser Ser Ser Gln Thr Glu Ile Gly 
                405                 410                 415     


Ser Leu Asn Ser Lys Gly Ser Leu Gly Lys Asp Thr Thr Ser Pro Met 
            420                 425                 430         


Glu Leu Ala Ala Leu Glu Lys Ile Lys Ser Thr Trp Ile Lys Asn Gln 
        435                 440                 445             


Asp Asp Ser Leu Thr Glu Thr Asp Thr Leu Glu Ile Thr Asp Gln Asp 
    450                 455                 460                 


Met Phe Gly Asp Ala Ser Thr Ser Leu Val Val Pro Glu Lys Val Lys 
465                 470                 475                 480 


Thr Pro Met Lys Ser Ser Lys Thr Asp Leu Gln Gly Ser Ala Ser Pro 
                485                 490                 495     


Ser Lys Val Glu Gly Val His Thr Pro Arg Gln Lys Arg Ser Thr Pro 
            500                 505                 510         


Leu Lys Glu Arg Gln Leu Ser Lys Pro Leu Ser Glu Arg Thr Asn Ser 
        515                 520                 525             


Ser Asp Ser Glu Arg Ser Pro Asp Leu Gly His Ser Thr Gln Ile Pro 
    530                 535                 540                 


Arg Lys Val Val Tyr Asp Gln Leu Asn Gln Ile Leu Val Ser Asp Ala 
545                 550                 555                 560 


Ala Leu Pro Glu Asn Val Ile Leu Val Asn Thr Thr Asp Trp Gln Gly 
                565                 570                 575     


Gln Tyr Val Ala Glu Leu Leu Gln Asp Gln Arg Lys Pro Val Val Cys 
            580                 585                 590         


Thr Cys Ser Thr Val Glu Val Gln Ala Val Leu Ser Ala Leu Leu Thr 
        595                 600                 605             


Arg Ile Gln Arg Tyr Cys Asn Cys Asn Ser Ser Met Pro Arg Pro Val 
    610                 615                 620                 


Lys Val Ala Ala Val Gly Gly Gln Ser Tyr Leu Ser Ser Ile Leu Arg 
625                 630                 635                 640 


Phe Phe Val Lys Ser Leu Ala Asn Lys Thr Ser Asp Trp Leu Gly Tyr 
                645                 650                 655     


Met Arg Phe Leu Ile Ile Pro Leu Gly Ser His Pro Val Ala Lys Tyr 
            660                 665                 670         


Leu Gly Ser Val Asp Ser Lys Tyr Ser Ser Ser Phe Leu Asp Ser Gly 
        675                 680                 685             


Trp Arg Asp Leu Phe Ser Arg Ser Glu Pro Pro Val Ser Glu Gln Leu 
    690                 695                 700                 


Asp Val Ala Gly Arg Val Met Gln Tyr Val Asn Gly Ala Ala Thr Thr 
705                 710                 715                 720 


His Gln Leu Pro Val Ala Glu Ala Met Leu Thr Cys Arg His Lys Phe 
                725                 730                 735     


Pro Asp Glu Asp Ser Tyr Gln Lys Phe Ile Pro Phe Ile Gly Val Val 
            740                 745                 750         


Lys Val Gly Leu Val Glu Asp Ser Pro Ser Thr Ala Gly Asp Gly Asp 
        755                 760                 765             


Asp Ser Pro Val Val Ser Leu Thr Val Pro Ser Thr Ser Pro Pro Ser 
    770                 775                 780                 


Ser Ser Gly Leu Ser Arg Asp Ala Thr Ala Thr Pro Pro Ser Ser Pro 
785                 790                 795                 800 


Ser Met Ser Ser Ala Leu Ala Ile Val Gly Ser Pro Asn Ser Pro Tyr 
                805                 810                 815     


Gly Asp Val Ile Gly Leu Gln Val Asp Tyr Trp Leu Gly His Pro Gly 
            820                 825                 830         


Glu Arg Arg Arg Glu Gly Asp Lys Arg Asp Ala Ser Ser Lys Asn Thr 
        835                 840                 845             


Leu Lys Ser Val Phe Arg Ser Val Gln Val Ser Arg Leu Pro His Ser 
    850                 855                 860                 


Gly Glu Ala Gln Leu Ser Gly Thr Met Ala Met Thr Val Val Thr Lys 
865                 870                 875                 880 


Glu Lys Asn Lys Lys Val Pro Thr Ile Phe Leu Ser Lys Lys Pro Arg 
                885                 890                 895     


Glu Lys Glu Val Asp Ser Lys Ser Gln Val Ile Glu Gly Ile Ser Arg 
            900                 905                 910         


Leu Ile Cys Ser Ala Lys Gln Gln Gln Thr Met Leu Arg Val Ser Ile 
        915                 920                 925             


Asp Gly Val Glu Trp Ser Asp Ile Lys Phe Phe Gln Leu Ala Ala Gln 
    930                 935                 940                 


Trp Pro Thr His Val Lys His Phe Pro Val Gly Leu Phe Ser Gly Ser 
945                 950                 955                 960 


Lys Ala Thr 
            


<210> 5424
<211> 181
<212> PRT
<213> Homo sapiens

<400> 5424
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Ala Pro Pro 
        35                  40                  45              


Val Pro Gln Val Pro Ala Leu Pro Arg Glu Gly Ser Pro Gly Asp Gln 
    50                  55                  60                  


Ala Ala Ala Leu Leu Thr Ala Arg Tyr Gln Glu Phe Val Thr Phe Glu 
65                  70                  75                  80  


Asp Val Ala Val His Leu Thr Arg Glu Glu Trp Gly Tyr Leu Asp Pro 
                85                  90                  95      


Val Gln Arg Asp Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Gly Asn 
            100                 105                 110         


Val Val Ser Leu Gly Ile Leu Leu Arg Leu Pro Thr Thr Arg Ile His 
        115                 120                 125             


Ser Val Asn Ser Cys Pro Ala Leu Ser His Thr Gln Ala Ser Ala Phe 
    130                 135                 140                 


Ser Gly Glu Thr Leu Ala Val Leu Thr Ala Gly Ile Ser Lys Arg Trp 
145                 150                 155                 160 


Pro Lys Tyr Arg Leu Pro Ile Asp Ile Ala Arg Pro Cys Ser Glu Thr 
                165                 170                 175     


Pro Phe Pro Arg Leu 
            180     


<210> 5425
<211> 469
<212> PRT
<213> Homo sapiens

<400> 5425
Met Val Leu Glu Gly Asn Pro Glu Val Gly Ser Pro Arg Thr Ser Asp 
1               5                   10                  15      


Leu Gln His Arg Gly Asn Lys Gly Ser Cys Val Leu Ser Ser Pro Gly 
            20                  25                  30          


Glu Asp Ala Gln Pro Gly Glu Glu Pro Ile Lys Tyr Gly Glu Leu Ile 
        35                  40                  45              


Val Leu Gly Cys Cys Glu Glu Gly Gly Glu Glu Thr Glu Ala Gln Arg 
    50                  55                  60                  


Gly Glu Val Thr Gly Pro Arg Ala His Ser Cys Tyr Asn Gly Cys Leu 
65                  70                  75                  80  


Ala Ser Gly Asp Lys Gly Arg Arg Arg Ser Arg Leu Ala Leu Ser Arg 
                85                  90                  95      


Arg Ser His Ala Asn Gly Val Lys Pro Asp Val Met His His Ile Ser 
            100                 105                 110         


Thr Pro Leu Val Ser Lys Ala Leu Ser Asn Arg Gly Gln His Ser Ile 
        115                 120                 125             


Ser Tyr Thr Leu Ser Arg Ser His Ser Val Ile Val Glu Tyr Thr His 
    130                 135                 140                 


Asp Ser Asp Thr Asp Met Phe Gln Ile Gly Arg Ser Thr Glu Asn Met 
145                 150                 155                 160 


Ile Asp Phe Val Val Thr Asp Thr Ser Pro Gly Gly Gly Ala Ala Glu 
                165                 170                 175     


Gly Pro Ser Ala Gln Ser Thr Ile Ser Arg Tyr Ala Cys Arg Ile Leu 
            180                 185                 190         


Cys Asp Arg Arg Pro Pro Tyr Thr Ala Arg Ile Tyr Ala Ala Gly Phe 
        195                 200                 205             


Asp Ala Ser Ser Asn Ile Phe Leu Gly Glu Arg Ala Ala Lys Trp Arg 
    210                 215                 220                 


Thr Pro Asp Gly Leu Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val 
225                 230                 235                 240 


Met His Pro Ala Gly Gly Phe Ser Glu Asp Ser Ala Pro Gly Val Trp 
                245                 250                 255     


Arg Glu Ile Ser Val Cys Gly Asn Val Tyr Thr Leu Arg Asp Ser Arg 
            260                 265                 270         


Ser Ala Gln Gln Arg Gly Lys Leu Val Glu Asn Glu Ser Asn Val Leu 
        275                 280                 285             


Gln Asp Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg 
    290                 295                 300                 


Thr Pro Ala Gly Leu Leu Arg Ala Pro Thr Leu Lys Gln Leu Glu Ala 
305                 310                 315                 320 


Gln Arg Gln Glu Ala Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Leu 
                325                 330                 335     


Ser Thr Leu Ala Phe Pro Ser Pro Ala Arg Gly Arg Thr Ala Pro Asp 
            340                 345                 350         


Lys Gln Gln Pro Trp Val Tyr Val Arg Cys Gly His Val His Gly Tyr 
        355                 360                 365             


His Gly Trp Gly Cys Arg Arg Glu Arg Gly Pro Gln Glu Arg Glu Cys 
    370                 375                 380                 


Pro Leu Cys Arg Leu Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Gln 
385                 390                 395                 400 


Glu Ala Gly Leu Cys Leu Asp Pro Gly Pro Pro Ser His Ala Phe Ala 
                405                 410                 415     


Pro Cys Gly His Val Cys Ser Glu Lys Thr Ala Arg Tyr Trp Ala Gln 
            420                 425                 430         


Thr Pro Leu Pro His Gly Thr His Ala Phe His Ala Ala Cys Pro Phe 
        435                 440                 445             


Cys Gly Ala Trp Leu Thr Gly Glu His Gly Cys Val Arg Leu Ile Phe 
    450                 455                 460                 


Gln Gly Pro Leu Asp 
465                 


<210> 5426
<211> 1103
<212> PRT
<213> Homo sapiens

<400> 5426
Met Ala Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn 
1               5                   10                  15      


Ala Arg Glu Thr Ser Gln Asp Ala Lys Cys Val Val Ser Met Gln Gly 
            20                  25                  30          


Asn Thr Thr Ser Ile Ile Asn Pro Lys Gln Ser Lys Asp Ala Pro Lys 
        35                  40                  45              


Ser Phe Thr Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Thr Glu Asp 
    50                  55                  60                  


Pro Gln Phe Ala Ser Gln Gln Gln Val Tyr Arg Asp Ile Gly Glu Glu 
65                  70                  75                  80  


Met Leu Leu His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Arg Gln Glu 
            100                 105                 110         


Pro Gly Gln Gln Gly Ile Val Pro Gln Leu Cys Glu Asp Leu Phe Ser 
        115                 120                 125             


Arg Val Ser Glu Asn Gln Ser Ala Gln Leu Ser Tyr Ser Val Glu Val 
    130                 135                 140                 


Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro 
145                 150                 155                 160 


Lys Ser Arg Gly Ser Leu Arg Val Arg Glu His Pro Ile Leu Gly Pro 
                165                 170                 175     


Tyr Val Gln Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Ala Asp Ile 
            180                 185                 190         


Ala Asp Leu Met Asp Cys Gly Asn Lys Ala Arg Thr Val Ala Ala Thr 
        195                 200                 205             


Asn Met Asn Glu Thr Ser Ser Arg Ser His Ala Val Phe Thr Ile Val 
    210                 215                 220                 


Phe Thr Gln Arg Cys His Asp Gln Leu Thr Gly Leu Asp Ser Glu Lys 
225                 230                 235                 240 


Val Ser Lys Ile Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Asp 
                245                 250                 255     


Ser Ser Gly Ala Arg Gly Met Arg Leu Lys Glu Gly Ala Asn Ile Asn 
            260                 265                 270         


Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Asp Met 
        275                 280                 285             


Gln Ser Lys Lys Arg Lys Ser Asp Phe Ile Pro Tyr Arg Asp Ser Val 
    290                 295                 300                 


Leu Thr Trp Leu Leu Lys Glu Asn Leu Gly Gly Asn Ser Arg Thr Ala 
305                 310                 315                 320 


Met Ile Ala Ala Leu Ser Pro Ala Asp Ile Asn Tyr Glu Glu Thr Leu 
                325                 330                 335     


Ser Thr Leu Arg Tyr Ala Asp Arg Thr Lys Gln Ile Arg Cys Asn Ala 
            340                 345                 350         


Ile Ile Asn Glu Asp Pro Asn Ala Arg Leu Ile Arg Glu Leu Gln Glu 
        355                 360                 365             


Glu Val Ala Arg Leu Arg Glu Leu Leu Met Ala Gln Gly Leu Ser Ala 
    370                 375                 380                 


Ser Ala Leu Glu Gly Leu Lys Thr Glu Glu Gly Ser Val Arg Gly Ala 
385                 390                 395                 400 


Leu Pro Ala Val Ser Ser Pro Pro Ala Pro Val Ser Pro Ser Ser Pro 
                405                 410                 415     


Thr Thr His Asn Gly Glu Leu Glu Pro Ser Phe Ser Pro Asn Thr Glu 
            420                 425                 430         


Ser Gln Ile Gly Pro Glu Glu Ala Met Glu Arg Leu Gln Glu Thr Glu 
        435                 440                 445             


Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys Leu Arg Lys 
    450                 455                 460                 


Thr Glu Ala Leu Arg Met Glu Arg Glu Ala Leu Leu Ala Glu Met Gly 
465                 470                 475                 480 


Val Ala Val Arg Glu Asp Gly Gly Thr Val Gly Val Phe Ser Pro Lys 
                485                 490                 495     


Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu Met Ser Glu 
            500                 505                 510         


Cys Leu Leu Tyr His Ile Lys Asp Gly Val Thr Arg Val Gly Gln Val 
        515                 520                 525             


Asp Met Asp Ile Lys Leu Thr Gly Gln Phe Ile Arg Glu Gln His Cys 
    530                 535                 540                 


Leu Phe Arg Ser Ile Pro Gln Pro Asp Gly Glu Val Val Val Thr Leu 
545                 550                 555                 560 


Glu Pro Cys Glu Gly Ala Glu Thr Tyr Val Asn Gly Lys Leu Val Thr 
                565                 570                 575     


Glu Pro Leu Val Leu Lys Ser Gly Asn Arg Ile Val Met Gly Lys Asn 
            580                 585                 590         


His Val Phe Arg Phe Asn His Pro Glu Gln Ala Arg Leu Glu Arg Glu 
        595                 600                 605             


Arg Gly Val Pro Pro Pro Pro Gly Pro Pro Ser Glu Pro Val Asp Trp 
    610                 615                 620                 


Asn Phe Ala Gln Lys Glu Leu Leu Glu Gln Gln Gly Ile Asp Ile Lys 
625                 630                 635                 640 


Leu Glu Met Glu Lys Arg Leu Gln Asp Leu Glu Asn Gln Tyr Arg Lys 
                645                 650                 655     


Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln Gln Arg Leu Tyr Ala 
            660                 665                 670         


Asp Ser Asp Ser Gly Asp Asp Ser Asp Lys Arg Ser Cys Glu Glu Ser 
        675                 680                 685             


Trp Arg Leu Ile Ser Ser Leu Arg Glu Gln Leu Pro Pro Thr Thr Val 
    690                 695                 700                 


Gln Thr Ile Val Lys Arg Cys Gly Leu Pro Ser Ser Gly Lys Arg Arg 
705                 710                 715                 720 


Ala Pro Arg Arg Val Tyr Gln Ile Pro Gln Arg Arg Arg Leu Gln Gly 
                725                 730                 735     


Lys Asp Pro Arg Trp Ala Thr Met Ala Asp Leu Lys Met Gln Ala Val 
            740                 745                 750         


Lys Glu Ile Cys Tyr Glu Val Ala Leu Ala Asp Phe Arg His Gly Arg 
        755                 760                 765             


Ala Glu Ile Glu Ala Leu Ala Ala Leu Lys Met Arg Glu Leu Cys Arg 
    770                 775                 780                 


Thr Tyr Gly Lys Pro Asp Gly Pro Gly Asp Ala Trp Arg Ala Val Ala 
785                 790                 795                 800 


Arg Asp Val Trp Asp Thr Val Gly Glu Glu Glu Gly Gly Gly Ala Gly 
                805                 810                 815     


Ser Gly Gly Gly Ser Glu Glu Gly Ala Arg Gly Ala Glu Val Glu Asp 
            820                 825                 830         


Leu Arg Ala His Ile Asp Lys Leu Thr Gly Ile Leu Gln Glu Val Lys 
        835                 840                 845             


Leu Gln Asn Ser Ser Lys Asp Arg Glu Leu Gln Ala Leu Arg Asp Arg 
    850                 855                 860                 


Met Leu Arg Met Glu Arg Val Ile Pro Leu Ala Gln Asp His Glu Asp 
865                 870                 875                 880 


Glu Asn Glu Glu Gly Gly Glu Val Pro Trp Ala Pro Pro Glu Gly Ser 
                885                 890                 895     


Glu Ala Ala Glu Glu Ala Ala Pro Ser Asp Arg Met Pro Ser Ala Arg 
            900                 905                 910         


Pro Pro Ser Pro Pro Leu Ser Ser Trp Glu Arg Val Ser Arg Leu Met 
        915                 920                 925             


Glu Glu Asp Pro Ala Phe Arg Arg Gly Arg Leu Arg Trp Leu Lys Gln 
    930                 935                 940                 


Glu Gln Leu Arg Leu Gln Gly Leu Gln Gly Ser Gly Gly Arg Gly Gly 
945                 950                 955                 960 


Gly Leu Arg Arg Pro Pro Ala Arg Phe Val Pro Pro His Asp Cys Lys 
                965                 970                 975     


Leu Arg Phe Pro Phe Lys Ser Asn Pro Gln His Arg Glu Ser Trp Pro 
            980                 985                 990         


Gly Met Gly Ser Gly Glu Ala Pro  Thr Pro Leu Gln Pro  Pro Glu Glu 
        995                 1000                 1005             


Val Thr  Pro His Pro Ala Thr  Pro Ala Arg Arg Pro  Pro Ser Pro 
    1010                 1015                 1020             


Arg Arg  Ser His His Pro Arg  Arg Asn Ser Leu Asp  Gly Gly Gly 
    1025                 1030                 1035             


Arg Ser  Arg Gly Ala Gly Ser  Ala Gln Pro Glu Pro  Gln His Phe 
    1040                 1045                 1050             


Gln Pro  Lys Lys His Asn Ser  Tyr Pro Gln Pro Pro  Gln Pro Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Arg Pro Pro Gly  Pro Arg Tyr Pro Pro  Tyr Thr Thr 
    1070                 1075                 1080             


Pro Pro  Arg Met Arg Arg Gln  Arg Ser Ala Pro Asp  Leu Lys Glu 
    1085                 1090                 1095             


Ser Gly  Ala Ala Val 
    1100             


<210> 5427
<211> 419
<212> PRT
<213> Homo sapiens

<400> 5427
Met Ala Glu Pro Val Gly Lys Arg Gly Arg Trp Ser Gly Gly Ser Gly 
1               5                   10                  15      


Ala Gly Arg Gly Gly Arg Gly Gly Trp Gly Gly Arg Gly Arg Arg Pro 
            20                  25                  30          


Arg Ala Gln Arg Ser Pro Ser Arg Gly Thr Leu Asp Val Val Ser Val 
        35                  40                  45              


Asp Leu Val Thr Asp Ser Asp Glu Glu Ile Leu Glu Val Ala Thr Ala 
    50                  55                  60                  


Arg Gly Ala Ala Asp Glu Val Glu Val Glu Pro Pro Glu Pro Pro Gly 
65                  70                  75                  80  


Pro Val Ala Ser Arg Asp Asn Ser Asn Ser Asp Ser Glu Gly Glu Asp 
                85                  90                  95      


Arg Arg Pro Ala Gly Pro Pro Arg Glu Pro Val Arg Arg Arg Arg Arg 
            100                 105                 110         


Leu Val Leu Asp Pro Gly Glu Ala Pro Leu Val Pro Val Tyr Ser Gly 
        115                 120                 125             


Lys Val Lys Ser Ser Leu Arg Leu Ile Pro Asp Asp Leu Ser Leu Leu 
    130                 135                 140                 


Lys Leu Tyr Pro Pro Gly Asp Glu Glu Glu Ala Glu Leu Ala Asp Ser 
145                 150                 155                 160 


Ser Gly Leu Tyr His Glu Gly Ser Pro Ser Pro Gly Ser Pro Trp Lys 
                165                 170                 175     


Thr Lys Leu Arg Thr Lys Asp Lys Glu Glu Lys Lys Lys Thr Glu Phe 
            180                 185                 190         


Leu Asp Leu Asp Asn Ser Pro Leu Ser Pro Pro Ser Pro Arg Thr Lys 
        195                 200                 205             


Ser Arg Thr His Thr Arg Ala Leu Lys Lys Leu Ser Glu Val Asn Lys 
    210                 215                 220                 


Arg Leu Gln Asp Leu Arg Ser Cys Leu Ser Pro Lys Pro Pro Gln Gly 
225                 230                 235                 240 


Gln Glu Gln Gln Gly Gln Glu Asp Glu Val Val Leu Val Glu Gly Pro 
                245                 250                 255     


Thr Leu Pro Glu Thr Pro Arg Leu Phe Pro Leu Lys Ile Arg Cys Arg 
            260                 265                 270         


Ala Asp Leu Val Arg Leu Pro Leu Arg Met Ser Glu Pro Leu Gln Ser 
        275                 280                 285             


Val Val Asp His Met Ala Thr His Leu Gly Val Ser Pro Ser Arg Ile 
    290                 295                 300                 


Leu Leu Leu Phe Gly Glu Thr Glu Leu Ser Pro Thr Ala Thr Pro Arg 
305                 310                 315                 320 


Thr Leu Lys Leu Gly Val Ala Asp Ile Ile Asp Cys Val Val Leu Thr 
                325                 330                 335     


Ser Ser Pro Glu Ala Thr Glu Thr Ser Gln Gln Leu Gln Leu Arg Val 
            340                 345                 350         


Gln Gly Lys Glu Lys His Gln Thr Leu Glu Val Ser Leu Ser Arg Asp 
        355                 360                 365             


Ser Pro Leu Lys Thr Leu Met Ser His Tyr Glu Glu Ala Met Gly Leu 
    370                 375                 380                 


Ser Gly Arg Lys Leu Ser Phe Phe Phe Asp Gly Thr Lys Leu Ser Gly 
385                 390                 395                 400 


Arg Glu Leu Pro Ala Asp Leu Gly Met Glu Ser Gly Asp Leu Ile Glu 
                405                 410                 415     


Val Trp Gly 
            


<210> 5428
<211> 127
<212> PRT
<213> Homo sapiens

<400> 5428
Met Arg Pro Leu Asp Ile Val Glu Leu Ala Glu Pro Glu Glu Val Glu 
1               5                   10                  15      


Val Leu Glu Pro Glu Glu Asp Phe Glu Gln Phe Leu Leu Pro Val Ile 
            20                  25                  30          


Asn Glu Met Arg Glu Asp Ile Ala Ser Leu Thr Arg Glu His Gly Arg 
        35                  40                  45              


Ala Tyr Leu Arg Asn Arg Ser Lys Leu Trp Glu Met Asp Asn Met Leu 
    50                  55                  60                  


Ile Gln Ile Lys Thr Gln Val Glu Ala Ser Glu Glu Ser Ala Leu Asn 
65                  70                  75                  80  


His Leu Gln Asn Pro Gly Asp Ala Ala Glu Gly Arg Ala Ala Lys Arg 
                85                  90                  95      


Cys Glu Lys Ala Glu Glu Lys Ala Lys Glu Ile Ala Lys Met Ala Glu 
            100                 105                 110         


Met Leu Val Glu Leu Val Arg Arg Ile Glu Lys Ser Glu Ser Ser 
        115                 120                 125         


<210> 5429
<211> 420
<212> PRT
<213> Homo sapiens

<400> 5429
Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 
1               5                   10                  15      


Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 
            20                  25                  30          


Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 
        35                  40                  45              


Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 
    50                  55                  60                  


Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 
65                  70                  75                  80  


Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 
                85                  90                  95      


Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 
            100                 105                 110         


Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 
        115                 120                 125             


Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 
    130                 135                 140                 


Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 
145                 150                 155                 160 


Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 
                165                 170                 175     


Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 
            180                 185                 190         


Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 
        195                 200                 205             


Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 
    210                 215                 220                 


Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 
225                 230                 235                 240 


Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 
                245                 250                 255     


Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 
            260                 265                 270         


Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 
        275                 280                 285             


Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 
    290                 295                 300                 


Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 
305                 310                 315                 320 


Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 
                325                 330                 335     


Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 
            340                 345                 350         


Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 
        355                 360                 365             


His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 
    370                 375                 380                 


Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys 
385                 390                 395                 400 


Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 
                405                 410                 415     


Glu Leu Lys Ser 
            420 


<210> 5430
<211> 115
<212> PRT
<213> Homo sapiens

<400> 5430
Met Arg Tyr Val Ala Ser Tyr Leu Leu Ala Ala Leu Gly Gly Asn Ser 
1               5                   10                  15      


Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly Ile 
            20                  25                  30          


Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly 
        35                  40                  45              


Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala Ser 
    50                  55                  60                  


Val Pro Ala Gly Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala 
65                  70                  75                  80  


Ala Pro Ala Ala Gly Ser Ala Pro Ala Ala Ala Glu Glu Lys Lys Asp 
                85                  90                  95      


Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly 
            100                 105                 110         


Leu Phe Asp 
        115 


<210> 5431
<211> 410
<212> PRT
<213> Homo sapiens

<400> 5431
Leu Asn Arg Ala Cys Phe Cys Val Thr Gly Val Pro Glu Leu Glu Val 
1               5                   10                  15      


Ile Cys Gly Leu Gln Gln Ala Glu Trp Pro Arg Leu Gly Leu Ser His 
            20                  25                  30          


Leu Gly Ala Val Gly Gly Gly Trp Gly Gly Leu Pro Thr Ser Thr Trp 
        35                  40                  45              


Val Ser Leu His Thr Gln Glu Val Asp Leu Ala Ser Glu Val Ala Leu 
    50                  55                  60                  


Glu Val Val Arg Thr Ala Glu Pro Gly Val Trp Leu Glu Ala Gln Ala 
65                  70                  75                  80  


Pro Val Ala Leu Val Ala Gln Pro Glu Pro Leu Pro Ala Thr Ala Gly 
                85                  90                  95      


Val Lys Arg Glu Ser Val Gly Met Glu Val Ala Val Leu Thr Asp Asp 
            100                 105                 110         


Pro Leu Pro Val Val Asp Gln Gln Gln Val Leu Ala Arg Leu Gln Leu 
        115                 120                 125             


Leu Glu Gln Gln Val Val Gly Gly Glu Gln Ala Lys Asn Lys Asp Leu 
    130                 135                 140                 


Lys Glu Lys His Lys Arg Arg Lys Arg Tyr Ala Asp Glu Arg Arg Lys 
145                 150                 155                 160 


Gln Leu Val Ala Ala Leu Gln Asn Ser Asp Glu Asp Ser Gly Asp Trp 
                165                 170                 175     


Val Leu Leu Asn Val Tyr Asp Ser Ile Gln Glu Glu Val Arg Ala Lys 
            180                 185                 190         


Ser Lys Leu Leu Glu Lys Met Gln Arg Lys Leu Arg Ala Ala Glu Val 
        195                 200                 205             


Glu Ile Lys Asp Leu Gln Ser Glu Phe Gln Leu Glu Lys Ile Asp Tyr 
    210                 215                 220                 


Leu Ala Thr Ile Arg Arg Gln Glu Arg Asp Ser Met Leu Leu Gln Gln 
225                 230                 235                 240 


Leu Leu Glu Gln Val Gln Pro Leu Ile Arg Arg Asp Cys Asn Tyr Ser 
                245                 250                 255     


Asn Leu Glu Lys Ile Leu Arg Glu Ser Cys Trp Asp Glu Asp Asn Gly 
            260                 265                 270         


Phe Trp Lys Ile Pro His Pro Val Ile Thr Lys Thr Ser Leu Pro Val 
        275                 280                 285             


Ala Val Ser Thr Gly Pro Gln Asn Lys Pro Ala Arg Lys Thr Ser Ala 
    290                 295                 300                 


Ala Asp Asn Gly Glu Pro Asn Met Glu Asp Asp Arg Tyr Arg Leu Met 
305                 310                 315                 320 


Leu Ser Arg Ser Asn Ser Glu Asn Ile Ala Ser Asn Tyr Phe Arg Ser 
                325                 330                 335     


Lys Arg Ala Ser Gln Ile Leu Ser Thr Asp Ala Arg Lys Ser Leu Thr 
            340                 345                 350         


His His Asn Ser Pro Pro Gly Leu Ser Cys Pro Leu Ser Asn Asn Ser 
        355                 360                 365             


Ala Ile Pro Pro Thr Gln Ala Pro Glu Met Pro Gln Pro Arg Pro Phe 
    370                 375                 380                 


Arg Leu Glu Ser Leu Asp Ile Pro Phe Thr Lys Ala Lys Arg Lys Lys 
385                 390                 395                 400 


Ser Lys Ser Asn Phe Gly Ser Glu Pro Leu 
                405                 410 


<210> 5432
<211> 450
<212> PRT
<213> Homo sapiens

<400> 5432
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Val Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Leu 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Ala Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ala Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Met Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu Gly Glu 
        435                 440                 445             


Glu Tyr 
    450 


<210> 5433
<211> 156
<212> PRT
<213> Homo sapiens

<400> 5433
Met Ser Gly Gly Leu Leu Lys Ala Leu Arg Ser Asp Ser Tyr Val Glu 
1               5                   10                  15      


Leu Ser Gln Tyr Arg Asp Gln His Phe Arg Gly Asp Asn Glu Glu Gln 
            20                  25                  30          


Glu Lys Leu Leu Lys Lys Ser Cys Thr Leu Tyr Val Gly Asn Leu Ser 
        35                  40                  45              


Phe Tyr Thr Thr Glu Glu Gln Ile Tyr Glu Leu Phe Ser Lys Ser Gly 
    50                  55                  60                  


Asp Ile Lys Lys Ile Ile Met Gly Leu Asp Lys Met Lys Lys Thr Ala 
65                  70                  75                  80  


Cys Gly Phe Cys Phe Val Glu Tyr Tyr Ser Arg Ala Asp Ala Glu Asn 
                85                  90                  95      


Ala Met Arg Tyr Ile Asn Gly Thr Arg Leu Asp Asp Arg Ile Ile Arg 
            100                 105                 110         


Thr Asp Trp Asp Ala Gly Phe Lys Glu Gly Arg Gln Tyr Gly Arg Gly 
        115                 120                 125             


Arg Ser Gly Gly Gln Val Arg Asp Glu Tyr Arg Gln Asp Tyr Asp Ala 
    130                 135                 140                 


Gly Arg Gly Gly Tyr Gly Lys Leu Ala Gln Asn Gln 
145                 150                 155     


<210> 5434
<211> 331
<212> PRT
<213> Homo sapiens

<400> 5434
Met Gly Gly Glu Gln Glu Glu Glu Arg Phe Asp Gly Met Leu Leu Ala 
1               5                   10                  15      


Met Ala Gln Gln His Glu Gly Gly Val Gln Glu Leu Val Asn Thr Phe 
            20                  25                  30          


Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile Gly Gly Glu Glu 
        35                  40                  45              


Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln 
    50                  55                  60                  


Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu 
65                  70                  75                  80  


Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys 
                85                  90                  95      


Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala 
            100                 105                 110         


Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His 
        115                 120                 125             


Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp 
    130                 135                 140                 


Thr Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys 
145                 150                 155                 160 


Pro Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln 
                165                 170                 175     


Thr Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys Val Asn Phe Arg 
            180                 185                 190         


Leu Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg Arg His Leu Arg 
        195                 200                 205             


Val Gly Leu Lys Gly Gln Pro Ala Ile Ile Asp Gly Glu Leu Tyr Asn 
    210                 215                 220                 


Glu Val Lys Val Glu Glu Ser Ser Trp Leu Ile Glu Asp Gly Lys Val 
225                 230                 235                 240 


Val Thr Val His Leu Glu Lys Ile Asn Lys Met Glu Trp Trp Ser Arg 
                245                 250                 255     


Leu Val Ser Ser Asp Pro Glu Ile Asn Thr Lys Lys Ile Asn Pro Glu 
            260                 265                 270         


Asn Ser Lys Leu Ser Asp Leu Asp Ser Glu Thr Arg Ser Met Val Glu 
        275                 280                 285             


Lys Met Met Tyr Asp Gln Arg Gln Lys Ser Met Gly Leu Pro Thr Ser 
    290                 295                 300                 


Asp Glu Gln Lys Lys Gln Glu Ile Leu Lys Lys Phe Met Asp Gln His 
305                 310                 315                 320 


Pro Glu Met Asp Phe Ser Lys Ala Lys Phe Asn 
                325                 330     


<210> 5435
<211> 619
<212> PRT
<213> Homo sapiens

<400> 5435
Met Ala Gly Pro Gly Val Pro Gly Ala Pro Ala Ala Arg Trp Lys Arg 
1               5                   10                  15      


His Ile Val Arg Gln Leu Arg Leu Arg Asp Arg Thr Gln Lys Ala Leu 
            20                  25                  30          


Phe Leu Glu Leu Val Pro Ala Tyr Asn His Leu Leu Glu Lys Ala Glu 
        35                  40                  45              


Leu Leu Asp Lys Phe Ser Lys Lys Leu Gln Pro Glu Pro Asn Ser Val 
    50                  55                  60                  


Thr Pro Thr Thr His Gln Gly Pro Trp Glu Glu Ser Glu Leu Asp Ser 
65                  70                  75                  80  


Asp Gln Val Pro Ser Leu Val Ala Leu Arg Val Lys Trp Gln Glu Glu 
                85                  90                  95      


Glu Glu Gly Leu Arg Leu Val Cys Gly Glu Met Ala Tyr Gln Val Val 
            100                 105                 110         


Glu Lys Gly Ala Ala Leu Gly Thr Leu Glu Ser Glu Leu Gln Gln Arg 
        115                 120                 125             


Gln Ser Arg Leu Ala Ala Leu Glu Ala Arg Val Ala Gln Leu Arg Glu 
    130                 135                 140                 


Ala Arg Ala Gln Gln Ala Gln Gln Val Glu Glu Trp Arg Ala Gln Asn 
145                 150                 155                 160 


Ala Val Gln Arg Ala Ala Tyr Glu Ala Leu Arg Ala His Val Gly Leu 
                165                 170                 175     


Arg Glu Ala Ala Leu Arg Arg Leu Gln Glu Glu Ala Arg Asp Leu Leu 
            180                 185                 190         


Glu Arg Leu Val Gln Arg Lys Ala Arg Ala Ala Ala Glu Arg Asn Leu 
        195                 200                 205             


Arg Asn Glu Arg Arg Glu Arg Ala Lys Gln Ala Arg Val Ser Gln Glu 
    210                 215                 220                 


Leu Lys Lys Ala Ala Lys Arg Thr Val Ser Ile Ser Glu Gly Pro Asp 
225                 230                 235                 240 


Thr Leu Gly Asp Gly Met Arg Glu Arg Arg Glu Thr Leu Ala Leu Ala 
                245                 250                 255     


Pro Glu Pro Glu Pro Leu Glu Lys Glu Ala Cys Glu Lys Trp Lys Arg 
            260                 265                 270         


Pro Phe Arg Ser Ala Ser Ala Thr Ser Leu Thr Leu Ser His Cys Val 
        275                 280                 285             


Asp Val Val Lys Gly Leu Leu Asp Phe Lys Lys Arg Arg Gly His Ser 
    290                 295                 300                 


Ile Gly Gly Ala Pro Glu Gln Arg Tyr Gln Ile Ile Pro Val Cys Val 
305                 310                 315                 320 


Ala Ala Arg Leu Pro Thr Arg Ala Gln Asp Val Leu Asp Ala His Leu 
                325                 330                 335     


Ser Glu Val Asn Ala Val Arg Phe Gly Pro Asn Ser Ser Leu Leu Ala 
            340                 345                 350         


Thr Gly Gly Ala Asp Arg Leu Ile His Leu Trp Asn Val Val Gly Ser 
        355                 360                 365             


Arg Leu Glu Ala Asn Gln Thr Leu Glu Gly Ala Gly Gly Ser Ile Thr 
    370                 375                 380                 


Ser Val Asp Phe Asp Pro Ser Gly Tyr Gln Val Leu Ala Ala Thr Tyr 
385                 390                 395                 400 


Asn Gln Ala Ala Gln Leu Trp Lys Val Gly Glu Ala Gln Ser Lys Glu 
                405                 410                 415     


Thr Leu Ser Gly His Lys Asp Lys Val Thr Ala Ala Lys Phe Lys Leu 
            420                 425                 430         


Thr Arg His Gln Ala Val Thr Gly Ser Arg Asp Arg Thr Val Lys Glu 
        435                 440                 445             


Trp Asp Leu Gly Arg Ala Tyr Cys Ser Arg Thr Ile Asn Val Leu Ser 
    450                 455                 460                 


Tyr Cys Asn Asp Val Val Cys Gly Asp His Ile Ile Ile Ser Gly His 
465                 470                 475                 480 


Asn Asp Gln Lys Ile Arg Phe Trp Asp Ser Arg Gly Pro His Cys Thr 
                485                 490                 495     


Gln Val Ile Pro Val Gln Gly Arg Val Thr Ser Leu Ser Leu Ser His 
            500                 505                 510         


Asp Gln Leu His Leu Leu Ser Cys Ser Arg Asp Asn Thr Leu Lys Val 
        515                 520                 525             


Ile Asp Leu Arg Val Ser Asn Ile Arg Gln Val Phe Arg Ala Asp Gly 
    530                 535                 540                 


Phe Lys Cys Gly Ser Asp Trp Thr Lys Ala Val Phe Ser Pro Asp Arg 
545                 550                 555                 560 


Ser Tyr Ala Leu Ala Gly Ser Cys Asp Gly Ala Leu Tyr Ile Trp Asp 
                565                 570                 575     


Val Asp Thr Gly Lys Leu Glu Ser Arg Leu Gln Gly Pro His Cys Ala 
            580                 585                 590         


Ala Val Asn Ala Val Ala Trp Cys Tyr Ser Gly Ser His Met Val Ser 
        595                 600                 605             


Val Asp Gln Gly Arg Lys Val Val Leu Trp Gln 
    610                 615                 


<210> 5436
<211> 1682
<212> PRT
<213> Homo sapiens

<400> 5436
Met Glu Gly Asn Gly Thr Glu Asn Ser Cys Ser Arg Thr Arg Gly Trp 
1               5                   10                  15      


Leu Gln Gln Asp Asn Asp Ala Lys Pro Trp Leu Trp Lys Phe Ser Asn 
            20                  25                  30          


Cys Phe Ser Arg Pro Glu Gln Thr Leu Pro His Ser Pro Gln Thr Lys 
        35                  40                  45              


Glu Tyr Met Glu Asn Lys Lys Val Ala Val Glu Leu Lys Asp Val Pro 
    50                  55                  60                  


Ser Pro Leu His Ala Gly Ser Lys Leu Phe Pro Ala Val Pro Leu Pro 
65                  70                  75                  80  


Asp Ile Arg Ser Leu Gln Gln Pro Lys Ile Gln Leu Ser Ser Val Pro 
                85                  90                  95      


Lys Val Ser Cys Cys Ala His Cys Pro Asn Glu Pro Ser Thr Ser Pro 
            100                 105                 110         


Met Arg Phe Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Ser Ser Leu 
        115                 120                 125             


Ile His Pro Gly Ala Leu Leu Asp Ser Gln Ser Thr Arg Thr Ile Thr 
    130                 135                 140                 


Cys Gln Val Gly Ser Gly Phe Ala Phe Gln Ser Ala Ser Ser Leu Gln 
145                 150                 155                 160 


Asn Ala Ser Ala Arg Asn Asn Leu Ala Gly Ile Ala Ser Asp Phe Pro 
                165                 170                 175     


Ser Met Cys Leu Glu Ser Asn Leu Ser Ser Cys Lys His Leu Pro Cys 
            180                 185                 190         


Cys Gly Lys Leu His Phe Gln Ser Cys His Gly Asn Val His Lys Leu 
        195                 200                 205             


His Gln Phe Pro Ser Leu Gln Gly Cys Thr Ser Ala Gly Tyr Phe Pro 
    210                 215                 220                 


Cys Ser Asp Phe Thr Ser Gly Ala Pro Gly His Leu Glu Glu His Ile 
225                 230                 235                 240 


Ser Gln Ser Glu Leu Thr Pro His Leu Cys Thr Asn Ser Leu His Leu 
                245                 250                 255     


Asn Val Val Pro Pro Val Cys Leu Lys Gly Ser Leu Tyr Cys Glu Asp 
            260                 265                 270         


Cys Leu Asn Lys Pro Ala Arg Asn Ser Ile Ile Asp Ala Ala Lys Val 
        275                 280                 285             


Trp Pro Asn Ile Pro Pro Pro Asn Thr Gln Pro Ala Pro Leu Ala Val 
    290                 295                 300                 


Pro Leu Cys Asn Gly Cys Gly Thr Lys Gly Thr Gly Lys Glu Thr Thr 
305                 310                 315                 320 


Leu Leu Leu Ala Thr Ser Leu Gly Lys Ala Ala Ser Lys Phe Gly Ser 
                325                 330                 335     


Pro Glu Val Ala Val Ala Gly Gln Val Leu Glu Asn Leu Pro Pro Ile 
            340                 345                 350         


Gly Val Phe Trp Asp Ile Glu Asn Cys Ser Val Pro Ser Gly Arg Ser 
        355                 360                 365             


Ala Thr Ala Val Val Gln Arg Ile Arg Glu Lys Phe Phe Lys Gly His 
    370                 375                 380                 


Arg Glu Ala Glu Phe Ile Cys Val Cys Asp Ile Ser Lys Glu Asn Lys 
385                 390                 395                 400 


Glu Val Ile Gln Glu Leu Asn Asn Cys Gln Val Thr Val Ala His Ile 
                405                 410                 415     


Asn Ala Thr Ala Lys Asn Ala Ala Asp Asp Lys Leu Arg Gln Ser Leu 
            420                 425                 430         


Arg Arg Phe Ala Asn Thr His Thr Ala Pro Ala Thr Val Val Leu Val 
        435                 440                 445             


Ser Thr Asp Val Asn Phe Ala Leu Glu Leu Ser Asp Leu Arg His Arg 
    450                 455                 460                 


His Gly Phe His Ile Ile Leu Val His Lys Asn Gln Ala Ser Glu Ala 
465                 470                 475                 480 


Leu Leu His His Ala Asn Glu Leu Ile Arg Phe Glu Glu Phe Ile Ser 
                485                 490                 495     


Asp Leu Pro Pro Arg Leu Pro Leu Lys Met Pro Gln Cys His Thr Leu 
            500                 505                 510         


Leu Tyr Val Tyr Asn Leu Pro Ala Asn Lys Asp Gly Lys Ser Val Ser 
        515                 520                 525             


Asn Arg Leu Arg Arg Leu Ser Asp Asn Cys Gly Gly Lys Val Leu Ser 
    530                 535                 540                 


Ile Thr Gly Cys Ser Ala Ile Leu Arg Phe Ile Asn Gln Asp Ser Ala 
545                 550                 555                 560 


Glu Arg Ala Gln Lys Arg Met Glu Asn Glu Asp Val Phe Gly Asn Arg 
                565                 570                 575     


Ile Ile Val Ser Phe Thr Pro Lys Asn Arg Glu Leu Cys Glu Thr Lys 
            580                 585                 590         


Ser Ser Asn Ala Ile Ala Asp Lys Val Lys Ser Pro Lys Lys Leu Lys 
        595                 600                 605             


Asn Pro Lys Leu Cys Leu Ile Lys Asp Ala Ser Glu Gln Ser Ser Ser 
    610                 615                 620                 


Ala Lys Ala Thr Pro Gly Lys Gly Ser Gln Ala Asn Ser Gly Ser Ala 
625                 630                 635                 640 


Thr Lys Asn Thr Asn Val Lys Ser Leu Gln Glu Leu Cys Arg Met Glu 
                645                 650                 655     


Ser Lys Thr Gly His Arg Asn Ser Glu His Gln Gln Gly His Leu Arg 
            660                 665                 670         


Leu Val Val Pro Thr His Gly Asn Ser Ser Ala Ala Val Ser Thr Pro 
        675                 680                 685             


Lys Asn Ser Gly Val Ala Glu Pro Val Tyr Lys Thr Ser Gln Lys Lys 
    690                 695                 700                 


Glu Asn Leu Ser Ala Arg Ser Val Thr Ser Ser Pro Val Glu Lys Lys 
705                 710                 715                 720 


Asp Lys Glu Glu Thr Val Phe Gln Val Ser Tyr Pro Ser Ala Phe Ser 
                725                 730                 735     


Lys Leu Val Ala Ser Arg Gln Val Ser Pro Leu Leu Ala Ser Gln Ser 
            740                 745                 750         


Trp Ser Ser Arg Ser Met Ser Pro Asn Leu Leu Asn Arg Ala Ser Pro 
        755                 760                 765             


Leu Ala Phe Asn Ile Ala Asn Ser Ser Ser Glu Ala Asp Cys Pro Asp 
    770                 775                 780                 


Pro Phe Ala Asn Gly Ala Asp Val Gln Val Ser Asn Ile Asp Tyr Arg 
785                 790                 795                 800 


Leu Ser Arg Lys Glu Leu Gln Gln Leu Leu Gln Glu Ala Phe Ala Arg 
                805                 810                 815     


His Gly Lys Val Lys Ser Val Glu Leu Ser Pro His Thr Asp Tyr Gln 
            820                 825                 830         


Leu Lys Ala Val Val Gln Met Glu Asn Leu Gln Asp Ala Ile Gly Ala 
        835                 840                 845             


Val Asn Ser Leu His Arg Tyr Lys Ile Gly Ser Lys Lys Ile Leu Val 
    850                 855                 860                 


Ser Leu Ala Thr Gly Ala Ala Ser Lys Ser Leu Ser Leu Leu Ser Ala 
865                 870                 875                 880 


Glu Thr Met Ser Val Leu Gln Asp Ala Pro Ala Cys Cys Leu Pro Leu 
                885                 890                 895     


Phe Lys Phe Thr Asp Ile Tyr Glu Lys Lys Phe Gly His Lys Leu Asn 
            900                 905                 910         


Val Ser Asp Leu Tyr Lys Leu Thr Asp Thr Val Ala Ile Arg Glu Gln 
        915                 920                 925             


Gly Asn Gly Arg Leu Val Cys Leu Leu Pro Ser Ser Gln Ala Arg Gln 
    930                 935                 940                 


Ser Pro Leu Gly Ser Ser Gln Ser His Asp Gly Ser Ser Thr Asn Cys 
945                 950                 955                 960 


Ser Pro Ile Ile Phe Glu Glu Leu Glu Tyr His Glu Pro Val Cys Arg 
                965                 970                 975     


Gln His Cys Ser Asn Lys Asp Phe Ser Glu His Glu Phe Asp Pro Asp 
            980                 985                 990         


Ser Tyr Lys Ile Pro Phe Val Ile  Leu Ser Leu Lys Thr  Phe Ala Pro 
        995                 1000                 1005             


Gln Val  His Ser Leu Leu Gln  Thr His Glu Gly Thr  Val Pro Leu 
    1010                 1015                 1020             


Leu Asp  Pro Trp Leu Leu Arg  Ser Lys Ser Pro Val  Gly Asn Pro 
    1025                 1030                 1035             


Gln Leu  Ile Gln Phe Ser Arg  Glu Val Ile Asp Leu  Leu Lys Ser 
    1040                 1045                 1050             


Gln Pro  Ser Cys Val Ile Pro  Ile Ser His Phe Ile  Pro Ser Tyr 
    1055                 1060                 1065             


His His  His Phe Ala Lys Gln  Cys Arg Val Ser Asp  Tyr Gly Tyr 
    1070                 1075                 1080             


Ser Lys  Leu Ile Glu Leu Leu  Glu Ala Val Pro His  Val Leu Gln 
    1085                 1090                 1095             


Ile Leu  Gly Met Gly Ser Lys  Arg Leu Leu Thr Leu  Thr His Arg 
    1100                 1105                 1110             


Ala Gln  Val Lys Arg Phe Thr  Gln Asp Leu Leu Lys  Leu Leu Lys 
    1115                 1120                 1125             


Ser Gln  Ala Ser Lys Gln Val  Ile Val Arg Glu Phe  Ser Gln Ala 
    1130                 1135                 1140             


Tyr His  Trp Cys Phe Ser Lys  Asp Trp Asp Val Thr  Glu Tyr Gly 
    1145                 1150                 1155             


Val Cys  Glu Leu Ile Asp Ile  Val Ser Glu Ile Pro  Asp Thr Thr 
    1160                 1165                 1170             


Ile Cys  Leu Ser Gln Gln Asp  Asn Glu Met Val Ile  Cys Ile Pro 
    1175                 1180                 1185             


Lys Arg  Glu Arg Thr Gln Asp  Glu Ile Glu Arg Thr  Lys Gln Phe 
    1190                 1195                 1200             


Ser Lys  Asp Val Val Asp Leu  Leu Arg His Gln Pro  His Phe Arg 
    1205                 1210                 1215             


Met Pro  Phe Asn Lys Phe Ile  Pro Ser Tyr His His  His Phe Gly 
    1220                 1225                 1230             


Arg Gln  Cys Lys Leu Ala Tyr  Tyr Gly Phe Thr Lys  Leu Leu Glu 
    1235                 1240                 1245             


Leu Phe  Glu Ala Ile Pro Asp  Thr Leu Gln Val Leu  Glu Cys Gly 
    1250                 1255                 1260             


Glu Glu  Lys Ile Leu Thr Leu  Thr Glu Val Glu Arg  Phe Lys Ala 
    1265                 1270                 1275             


Leu Ala  Ala Gln Phe Val Lys  Leu Leu Arg Ser Gln  Lys Asp Asn 
    1280                 1285                 1290             


Cys Leu  Met Met Thr Asp Leu  Leu Thr Glu Tyr Ala  Lys Thr Phe 
    1295                 1300                 1305             


Gly Tyr  Thr Phe Arg Leu Gln  Asp Tyr Asp Val Ser  Ser Ile Ser 
    1310                 1315                 1320             


Ala Leu  Thr Gln Lys Leu Cys  His Val Val Lys Val  Ala Asp Ile 
    1325                 1330                 1335             


Glu Ser  Gly Arg Gln Ile Gln  Leu Ile Asn Arg Lys  Ser Leu Arg 
    1340                 1345                 1350             


Ser Leu  Thr Ala Gln Leu Leu  Val Leu Leu Met Ser  Trp Glu Gly 
    1355                 1360                 1365             


Thr Thr  His Leu Ser Val Glu  Glu Leu Lys Arg His  Tyr Glu Ser 
    1370                 1375                 1380             


Thr His  Asn Thr Pro Leu Asn  Pro Cys Glu Tyr Gly  Phe Met Thr 
    1385                 1390                 1395             


Leu Thr  Glu Leu Leu Lys Ser  Leu Pro Tyr Leu Val  Glu Val Phe 
    1400                 1405                 1410             


Thr Asn  Asp Lys Met Glu Glu  Cys Val Lys Leu Thr  Ser Leu Tyr 
    1415                 1420                 1425             


Leu Phe  Ala Lys Asn Val Arg  Ser Leu Leu His Thr  Tyr His Tyr 
    1430                 1435                 1440             


Gln Gln  Ile Phe Leu His Glu  Phe Ser Met Ala Tyr  Thr Lys Tyr 
    1445                 1450                 1455             


Val Gly  Glu Thr Leu Gln Pro  Lys Thr Tyr Gly His  Ser Ser Val 
    1460                 1465                 1470             


Glu Glu  Leu Leu Gly Ala Ile  Pro Gln Val Val Trp  Ile Lys Gly 
    1475                 1480                 1485             


His Gly  His Lys Arg Ile Val  Val Leu Lys Asn Asp  Met Lys Ser 
    1490                 1495                 1500             


Arg Leu  Ser Ser Leu Ser Leu  Ser Pro Ala Asn His  Glu Asn Gln 
    1505                 1510                 1515             


Pro Ser  Glu Gly Glu Arg Ile  Leu Glu Val Pro Glu  Ser His Thr 
    1520                 1525                 1530             


Ala Ser  Glu Leu Lys Leu Gly  Ala Asp Gly Ser Gly  Pro Ser His 
    1535                 1540                 1545             


Thr Glu  Gln Glu Leu Leu Arg  Leu Thr Asp Asp Ser  Pro Val Asp 
    1550                 1555                 1560             


Leu Leu  Cys Ala Pro Val Pro  Ser Cys Leu Pro Ser  Pro Gln Leu 
    1565                 1570                 1575             


Arg Pro  Asp Pro Val Ile Leu  Gln Ser Ala Asp Leu  Ile Gln Phe 
    1580                 1585                 1590             


Glu Glu  Arg Pro Gln Glu Pro  Ser Glu Ile Met Ile  Leu Asn Gln 
    1595                 1600                 1605             


Glu Glu  Lys Met Glu Ile Pro  Ile Pro Gly Lys Ser  Lys Thr Leu 
    1610                 1615                 1620             


Thr Ser  Asp Ser Ser Ser Ser  Cys Ile Ser Ala Ala  Val Pro Val 
    1625                 1630                 1635             


Pro Pro  Cys Pro Ser Ser Glu  Thr Ser Glu Ser Leu  Leu Ser Lys 
    1640                 1645                 1650             


Asp Pro  Val Glu Ser Pro Ala  Lys Lys Gln Pro Lys  Asn Arg Val 
    1655                 1660                 1665             


Lys Leu  Ala Ala Asn Phe Ser  Leu Ala Pro Ile Thr  Lys Leu 
    1670                 1675                 1680         


<210> 5437
<211> 244
<212> PRT
<213> Homo sapiens

<400> 5437
Gly Gly Gly Tyr Asp Leu Asn Leu Phe Ala Ser Pro Pro Asp Ser Asn 
1               5                   10                  15      


Phe Val Cys Ser Val Cys His Gly Val Leu Lys Arg Pro Ala Arg Leu 
            20                  25                  30          


Pro Cys Ser His Ile Phe Cys Lys Lys Cys Ile Leu Arg Trp Leu Ala 
        35                  40                  45              


Arg Gln Lys Thr Cys Pro Cys Cys Arg Lys Glu Val Lys Arg Lys Lys 
    50                  55                  60                  


Val Val His Met Asn Lys Leu Arg Lys Thr Ile Gly Arg Leu Glu Val 
65                  70                  75                  80  


Lys Cys Lys Asn Ala Asp Ala Gly Cys Ile Val Thr Cys Pro Leu Ala 
                85                  90                  95      


His Arg Lys Gly His Gln Asp Ser Cys Pro Phe Glu Leu Thr Ala Cys 
            100                 105                 110         


Pro Asn Glu Gly Cys Thr Ser Gln Val Pro Arg Gly Thr Leu Ala Glu 
        115                 120                 125             


His Arg Gln His Cys Gln Gln Gly Ser Gln Gln Arg Cys Pro Leu Gly 
    130                 135                 140                 


Cys Gly Ala Thr Leu Asp Pro Ala Glu Arg Ala Arg His Asn Cys Tyr 
145                 150                 155                 160 


Arg Glu Leu His Asn Ala Trp Ser Val Arg Gln Glu Arg Arg Arg Pro 
                165                 170                 175     


Leu Leu Leu Ser Leu Leu Arg Arg Val Arg Trp Leu Asp Gln Ala Thr 
            180                 185                 190         


Ser Val Val Arg Arg Glu Leu Ala Glu Leu Ser Asn Phe Leu Glu Glu 
        195                 200                 205             


Asp Thr Ala Leu Leu Glu Gly Ala Pro Gln Glu Glu Ala Glu Ala Ala 
    210                 215                 220                 


Pro Glu Gly Asn Val Gly Ala Glu Val Val Gly Glu Pro Arg Ala Asn 
225                 230                 235                 240 


Ile Pro Cys Lys 
                


<210> 5438
<211> 234
<212> PRT
<213> Homo sapiens

<400> 5438
Leu Pro Cys Lys Arg Cys Arg Pro Ser Val Tyr Ser Leu Ser Tyr Ile 
1               5                   10                  15      


Lys Arg Gly Lys Thr Arg Asn Tyr Leu Tyr Pro Ile Trp Ser Pro Tyr 
            20                  25                  30          


Ala Tyr Tyr Leu Tyr Cys Tyr Lys Tyr Arg Ile Thr Leu Arg Glu Lys 
        35                  40                  45              


Met Leu Pro Arg Cys Tyr Lys Ser Ile Thr Tyr Lys Glu Glu Glu Asp 
    50                  55                  60                  


Leu Thr Leu Gln Pro Arg Ser Cys Leu Gln Cys Glu Ser Leu Val Gly 
65                  70                  75                  80  


Leu Gln Glu Gly Lys Ser Thr Glu Gln Gly Asn His Asp Gln Leu Lys 
                85                  90                  95      


Glu Leu Tyr Ser Ala Gly Asn Leu Thr Val Leu Ala Thr Asp Pro Leu 
            100                 105                 110         


Leu His Gln Asp Pro Val Gln Leu Asp Phe His Phe Arg Leu Thr Ser 
        115                 120                 125             


Gln Thr Ser Ala His Trp His Gly Leu Leu Cys Asp Arg Arg Leu Phe 
    130                 135                 140                 


Leu Asp Ile Pro Tyr Gln Ala Leu Asp Gln Gly Asn Arg Glu Ser Leu 
145                 150                 155                 160 


Thr Ala Thr Leu Glu Tyr Val Glu Glu Lys Thr Asn Val Asp Ser Val 
                165                 170                 175     


Phe Val Asn Phe Gln Asn Asp Arg Asn Asp Arg Gly Ala Leu Leu Arg 
            180                 185                 190         


Ala Phe Ser Tyr Met Gly Phe Glu Val Val Arg Pro Asp His Pro Ala 
        195                 200                 205             


Leu Pro Pro Leu Asp Asn Val Ile Phe Met Val Tyr Pro Leu Glu Arg 
    210                 215                 220                 


Asp Val Gly His Leu Pro Ser Glu Pro Pro 
225                 230                 


<210> 5439
<211> 800
<212> PRT
<213> Homo sapiens

<400> 5439
Met Ala Ala Ala Ala Ser Val Thr Gly Arg Val Thr Trp Ala Ala Ser 
1               5                   10                  15      


Pro Met Arg Ser Leu Gly Leu Gly Arg Arg Leu Ser Leu Pro Gly Pro 
            20                  25                  30          


Arg Leu Asp Ala Val Thr Ala Ala Val Asn Pro Ser Leu Ser Asp His 
        35                  40                  45              


Gly Asn Gly Leu Gly Arg Gly Thr Arg Gly Ser Gly Cys Ser Gly Gly 
    50                  55                  60                  


Ser Leu Val Ala Asp Trp Gly Gly Gly Ala Ala Ala Ala Ala Ala Val 
65                  70                  75                  80  


Ala Leu Ala Leu Ala Pro Ala Leu Ser Thr Met Arg Arg Gly Ser Ser 
                85                  90                  95      


Glu Ser Glu Leu Ala Ala Arg Trp Glu Ala Glu Ala Val Ala Ala Ala 
            100                 105                 110         


Lys Ala Ala Ala Lys Ala Glu Ala Glu Ala Thr Ala Glu Thr Val Ala 
        115                 120                 125             


Glu Gln Val Arg Val Asp Ala Gly Ala Ala Gly Glu Pro Glu Cys Lys 
    130                 135                 140                 


Ala Gly Glu Glu Gln Pro Lys Val Leu Ala Pro Ala Pro Ala Gln Pro 
145                 150                 155                 160 


Ser Ala Ala Glu Glu Gly Asn Thr Gln Val Leu Gln Arg Pro Pro Pro 
                165                 170                 175     


Thr Leu Pro Pro Ser Lys Pro Lys Pro Val Gln Gly Leu Cys Pro His 
            180                 185                 190         


Gly Lys Pro Arg Asp Lys Gly Arg Ser Cys Lys Arg Ser Ser Gly His 
        195                 200                 205             


Gly Ser Gly Glu Asn Gly Ser Gln Arg Pro Val Thr Val Asp Ser Ser 
    210                 215                 220                 


Lys Ala Arg Thr Ser Leu Asp Ala Leu Lys Ile Ser Ile Arg Gln Leu 
225                 230                 235                 240 


Lys Trp Lys Glu Phe Pro Phe Gly Arg Arg Leu Pro Cys Asp Ile Tyr 
                245                 250                 255     


Trp His Gly Val Ser Phe His Asp Asn Asp Ile Phe Ser Gly Gln Val 
            260                 265                 270         


Asn Lys Phe Pro Gly Met Thr Glu Met Val Arg Lys Ile Thr Leu Ser 
        275                 280                 285             


Arg Ala Val Arg Thr Met Gln Asn Leu Phe Pro Glu Glu Tyr Asn Phe 
    290                 295                 300                 


Tyr Pro Arg Ser Trp Ile Leu Pro Asp Glu Phe Gln Leu Phe Val Ala 
305                 310                 315                 320 


Gln Val Gln Met Val Lys Asp Asp Asp Pro Ser Trp Lys Pro Thr Phe 
                325                 330                 335     


Ile Val Lys Pro Asp Gly Gly Cys Gln Gly Asp Gly Ile Tyr Leu Ile 
            340                 345                 350         


Lys Asp Pro Ser Asp Ile Arg Leu Ala Gly Thr Leu Gln Ser Arg Pro 
        355                 360                 365             


Ala Val Val Gln Glu Tyr Ile Cys Lys Pro Leu Leu Ile Asp Lys Leu 
    370                 375                 380                 


Lys Phe Asp Ile Arg Leu Tyr Val Leu Leu Lys Ser Leu Asp Pro Leu 
385                 390                 395                 400 


Glu Ile Tyr Ile Ala Lys Asp Gly Leu Ser Arg Phe Cys Thr Glu Pro 
                405                 410                 415     


Tyr Gln Glu Pro Thr Pro Lys Asn Leu His Arg Ile Phe Met His Leu 
            420                 425                 430         


Thr Asn Tyr Ser Leu Asn Ile His Ser Gly Asn Phe Ile His Ser Asp 
        435                 440                 445             


Ser Ala Ser Thr Gly Ser Lys Arg Thr Phe Ser Ser Ile Leu Cys Arg 
    450                 455                 460                 


Leu Ser Ser Lys Gly Val Asp Ile Lys Lys Val Trp Ser Asp Ile Ile 
465                 470                 475                 480 


Ser Val Val Ile Lys Thr Val Ile Ala Leu Thr Pro Glu Leu Lys Val 
                485                 490                 495     


Phe Tyr Gln Ser Asp Ile Pro Thr Gly Arg Pro Gly Pro Thr Cys Phe 
            500                 505                 510         


Gln Ile Leu Gly Phe Asp Ile Leu Leu Met Lys Asn Leu Lys Pro Ile 
        515                 520                 525             


Leu Leu Glu Val Asn Ala Asn Pro Ser Met Arg Ile Glu His Glu His 
    530                 535                 540                 


Glu Leu Ser Pro Gly Val Phe Glu Asn Val Pro Ser Leu Val Asp Glu 
545                 550                 555                 560 


Glu Val Lys Val Ala Val Ile Arg Asp Thr Leu Arg Leu Met Asp Pro 
                565                 570                 575     


Leu Lys Lys Lys Arg Glu Asn Gln Ser Gln Gln Leu Glu Lys Pro Phe 
            580                 585                 590         


Ala Gly Lys Glu Asp Ala Leu Asp Gly Glu Leu Thr Ser Ala Pro Asp 
        595                 600                 605             


Cys Asn Ala Asn Pro Glu Ala His Leu Pro Ser Ile Cys Leu Lys Gln 
    610                 615                 620                 


Val Phe Pro Lys Tyr Ala Lys Gln Phe Asn Tyr Leu Arg Leu Val Asp 
625                 630                 635                 640 


Arg Met Ala Asn Leu Phe Ile Arg Phe Leu Gly Ile Lys Gly Thr Met 
                645                 650                 655     


Lys Leu Gly Pro Thr Gly Phe Arg Thr Phe Ile Arg Ser Cys Lys Leu 
            660                 665                 670         


Ser Ser Ser Ser Leu Ser Met Ala Ala Val Asp Ile Leu Tyr Ile Asp 
        675                 680                 685             


Ile Thr Arg Arg Trp Asn Ser Met Thr Leu Asp Gln Arg Asp Ser Gly 
    690                 695                 700                 


Met Cys Leu Gln Ala Phe Val Glu Ala Phe Phe Phe Leu Ala Gln Arg 
705                 710                 715                 720 


Lys Phe Lys Met Leu Pro Leu His Glu Gln Val Ala Ser Leu Ile Asp 
                725                 730                 735     


Leu Cys Glu Tyr His Leu Ser Leu Leu Asp Glu Lys Arg Leu Val Cys 
            740                 745                 750         


Gly Arg Gly Val Pro Ser Gly Gly Arg Pro Pro His Arg Gly Pro Pro 
        755                 760                 765             


Gln Glu Pro Ser Pro Ser Ala Gln Pro Ala Gly Asp Asn Pro Pro Pro 
    770                 775                 780                 


Arg Thr Ser Cys Ala Asn Lys Leu Ser His Pro Arg His Thr Leu Ser 
785                 790                 795                 800 


<210> 5440
<211> 326
<212> PRT
<213> Homo sapiens

<400> 5440
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Lys Ser Phe 
        115                 120                 125             


Phe Ala Thr Lys Pro Arg Ile His Phe Pro Leu Ala Thr Tyr Ala Pro 
    130                 135                 140                 


Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val Ala Glu 
145                 150                 155                 160 


Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys Cys Asp 
                165                 170                 175     


Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg Gly Asp 
            180                 185                 190         


Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys Thr Lys 
        195                 200                 205             


Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys Val Gly 
    210                 215                 220                 


Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu Ala Lys 
225                 230                 235                 240 


Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Val Ala Glu 
                245                 250                 255     


Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Pro Leu Arg Arg 
            260                 265                 270         


Ile Met Arg Arg Leu Glu Gln Ile Val Leu Thr Glu Arg Met Arg Val 
        275                 280                 285             


Lys Ser Ile Asn Leu Cys Ala Val Leu Leu His Ser Phe Val Leu Glu 
    290                 295                 300                 


Leu Ser Tyr Phe Cys Ser Val Asn Val Tyr Cys Arg Lys Leu Leu Ile 
305                 310                 315                 320 


Lys Leu Lys Phe Pro Phe 
                325     


<210> 5441
<211> 334
<212> PRT
<213> Homo sapiens

<400> 5441
Met Val Gly Arg Glu Lys Glu Leu Ser Ile His Phe Val Pro Gly Ser 
1               5                   10                  15      


Cys Arg Leu Val Glu Glu Glu Val Asn Ile Pro Asn Arg Arg Val Leu 
            20                  25                  30          


Val Thr Gly Ala Thr Gly Leu Leu Gly Arg Ala Val His Lys Glu Phe 
        35                  40                  45              


Gln Gln Asn Asn Trp His Ala Val Gly Cys Gly Phe Arg Arg Ala Arg 
    50                  55                  60                  


Pro Lys Phe Glu Gln Val Asn Leu Leu Asp Ser Asn Ala Val His His 
65                  70                  75                  80  


Ile Ile His Asp Phe Gln Pro His Val Ile Val His Cys Ala Ala Glu 
                85                  90                  95      


Arg Arg Pro Asp Val Val Glu Asn Gln Pro Asp Ala Ala Ser Gln Leu 
            100                 105                 110         


Asn Val Asp Ala Ser Gly Asn Leu Ala Lys Glu Ala Ala Ala Val Gly 
        115                 120                 125             


Ala Phe Leu Ile Tyr Ile Ser Ser Asp Tyr Val Phe Asp Gly Thr Asn 
    130                 135                 140                 


Pro Pro Tyr Arg Glu Glu Asp Ile Pro Ala Pro Leu Asn Leu Tyr Gly 
145                 150                 155                 160 


Lys Thr Lys Leu Asp Gly Glu Lys Ala Val Leu Glu Asn Asn Leu Gly 
                165                 170                 175     


Ala Ala Val Leu Arg Ile Pro Ile Leu Tyr Gly Glu Val Glu Lys Leu 
            180                 185                 190         


Glu Glu Ser Ala Val Thr Val Met Phe Asp Lys Val Gln Phe Ser Asn 
        195                 200                 205             


Lys Ser Ala Asn Met Asp His Trp Gln Gln Arg Phe Pro Thr His Val 
    210                 215                 220                 


Lys Asp Val Ala Thr Val Cys Arg Gln Leu Ala Glu Lys Arg Met Leu 
225                 230                 235                 240 


Asp Pro Ser Ile Lys Gly Thr Phe His Trp Ser Gly Asn Glu Gln Met 
                245                 250                 255     


Thr Lys Tyr Glu Met Ala Cys Ala Ile Ala Asp Ala Phe Asn Leu Pro 
            260                 265                 270         


Ser Ser His Leu Arg Pro Ile Thr Asp Ser Pro Val Leu Gly Ala Gln 
        275                 280                 285             


Arg Pro Arg Asn Ala Gln Leu Asp Cys Ser Lys Leu Glu Thr Leu Gly 
    290                 295                 300                 


Ile Gly Gln Arg Thr Pro Phe Arg Ile Gly Ile Lys Glu Ser Leu Trp 
305                 310                 315                 320 


Pro Phe Leu Ile Asp Lys Arg Trp Arg Gln Thr Val Phe His 
                325                 330                 


<210> 5442
<211> 170
<212> PRT
<213> Homo sapiens

<400> 5442
Met Ala Ser Glu Ala Glu Lys Thr Phe His Arg Phe Ala Ala Phe Gly 
1               5                   10                  15      


Glu Ser Ser Ser Ser Gly Thr Glu Met Asn Asn Lys Asn Phe Ser Lys 
            20                  25                  30          


Leu Cys Lys Asp Cys Gly Ile Met Asp Gly Lys Thr Val Thr Ser Thr 
        35                  40                  45              


Asp Val Asp Ile Val Phe Ser Lys Val Lys Ala Lys Asn Ala Arg Thr 
    50                  55                  60                  


Ile Thr Phe Gln Gln Phe Lys Glu Ala Val Lys Glu Leu Gly Gln Lys 
65                  70                  75                  80  


Arg Phe Lys Gly Lys Ser Pro Asp Glu Val Leu Glu Asn Ile Tyr Gly 
                85                  90                  95      


Leu Met Glu Gly Lys Asp Pro Ala Thr Thr Gly Ala Thr Lys Ala Thr 
            100                 105                 110         


Thr Val Gly Ala Val Asp Arg Leu Thr Asp Thr Ser Lys Tyr Thr Gly 
        115                 120                 125             


Thr His Lys Glu Arg Phe Asp Glu Ser Gly Lys Gly Lys Gly Ile Ala 
    130                 135                 140                 


Gly Arg Glu Glu Met Thr Asp Asn Thr Gly Tyr Val Ser Gly Tyr Lys 
145                 150                 155                 160 


Gly Ser Gly Thr Tyr Asp Lys Lys Thr Lys 
                165                 170 


<210> 5443
<211> 1193
<212> PRT
<213> Homo sapiens

<400> 5443
Met Trp Arg Val Lys Lys Leu Ser Leu Ser Leu Ser Pro Ser Pro Gln 
1               5                   10                  15      


Thr Gly Lys Pro Ser Met Arg Thr Pro Leu Arg Glu Leu Thr Leu Gln 
            20                  25                  30          


Pro Gly Ala Leu Thr Asn Ser Gly Lys Arg Ser Pro Ala Cys Ser Ser 
        35                  40                  45              


Leu Thr Pro Ser Leu Cys Lys Leu Gly Leu Gln Glu Gly Ser Asn Asn 
    50                  55                  60                  


Ser Ser Pro Val Asp Phe Val Asn Asn Lys Arg Thr Asp Leu Ser Ser 
65                  70                  75                  80  


Glu His Phe Ser His Ser Ser Lys Trp Leu Glu Thr Cys Gln His Glu 
                85                  90                  95      


Ser Asp Glu Gln Pro Leu Asp Pro Ile Pro Gln Ile Ser Ser Thr Pro 
            100                 105                 110         


Lys Thr Ser Glu Glu Ala Val Asp Pro Leu Gly Asn Tyr Met Val Lys 
        115                 120                 125             


Thr Ile Val Leu Val Pro Ser Pro Leu Gly Gln Gln Gln Asp Met Ile 
    130                 135                 140                 


Phe Glu Ala Arg Leu Asp Thr Met Ala Glu Thr Asn Ser Ile Ser Leu 
145                 150                 155                 160 


Asn Gly Pro Leu Arg Thr Asp Asp Leu Val Arg Glu Glu Val Ala Pro 
                165                 170                 175     


Cys Met Gly Asp Arg Phe Ser Glu Val Ala Ala Val Ser Glu Lys Pro 
            180                 185                 190         


Ile Phe Gln Glu Ser Pro Ser His Leu Leu Glu Glu Ser Pro Pro Asn 
        195                 200                 205             


Pro Cys Ser Glu Gln Leu His Cys Ser Lys Glu Ser Leu Ser Ser Arg 
    210                 215                 220                 


Thr Glu Ala Val Arg Glu Asp Leu Val Pro Ser Glu Ser Asn Ala Phe 
225                 230                 235                 240 


Leu Pro Ser Ser Val Leu Trp Leu Ser Pro Ser Thr Ala Leu Ala Ala 
                245                 250                 255     


Asp Phe Arg Val Asn His Val Asp Pro Glu Glu Glu Ile Val Glu His 
            260                 265                 270         


Gly Ala Met Glu Glu Arg Glu Met Arg Phe Pro Thr His Pro Lys Glu 
        275                 280                 285             


Ser Glu Thr Glu Asp Gln Ala Leu Val Ser Ser Val Glu Asp Ile Leu 
    290                 295                 300                 


Ser Thr Cys Leu Thr Pro Asn Leu Val Glu Met Glu Ser Gln Glu Ala 
305                 310                 315                 320 


Pro Gly Pro Ala Val Glu Asp Val Gly Arg Ile Leu Gly Ser Asp Thr 
                325                 330                 335     


Glu Ser Trp Met Ser Pro Leu Ala Trp Leu Glu Lys Gly Val Asn Thr 
            340                 345                 350         


Ser Val Met Leu Glu Asn Leu Arg Gln Ser Leu Ser Leu Pro Ser Met 
        355                 360                 365             


Leu Arg Asp Ala Ala Ile Gly Thr Thr Pro Phe Ser Thr Cys Ser Val 
    370                 375                 380                 


Gly Thr Trp Phe Thr Pro Ser Ala Pro Gln Glu Lys Ser Thr Asn Thr 
385                 390                 395                 400 


Ser Gln Thr Gly Leu Val Gly Thr Lys His Ser Thr Ser Glu Thr Glu 
                405                 410                 415     


Gln Leu Leu Cys Gly Arg Pro Pro Asp Leu Thr Ala Leu Ser Arg His 
            420                 425                 430         


Asp Leu Glu Asp Asn Leu Leu Ser Ser Leu Val Ile Leu Glu Val Leu 
        435                 440                 445             


Ser Arg Gln Leu Arg Asp Trp Lys Ser Gln Leu Ala Val Pro His Pro 
    450                 455                 460                 


Glu Thr Gln Asp Ser Ser Thr Gln Thr Asp Thr Ser His Ser Gly Ile 
465                 470                 475                 480 


Thr Asn Lys Leu Gln His Leu Lys Glu Ser His Glu Met Gly Gln Ala 
                485                 490                 495     


Leu Gln Gln Ala Arg Asn Val Met Gln Ser Trp Val Leu Ile Ser Lys 
            500                 505                 510         


Glu Leu Ile Ser Leu Leu His Leu Ser Leu Leu His Leu Glu Glu Asp 
        515                 520                 525             


Lys Thr Thr Val Ser Gln Glu Ser Arg Arg Ala Glu Thr Leu Val Cys 
    530                 535                 540                 


Cys Cys Phe Asp Leu Leu Lys Lys Leu Arg Ala Lys Leu Gln Ser Leu 
545                 550                 555                 560 


Lys Ala Glu Arg Glu Glu Ala Arg His Arg Glu Glu Met Ala Leu Arg 
                565                 570                 575     


Gly Lys Asp Ala Ala Glu Ile Val Leu Glu Ala Phe Cys Ala His Ala 
            580                 585                 590         


Ser Gln Arg Ile Ser Gln Leu Glu Gln Asp Leu Ala Ser Met Arg Glu 
        595                 600                 605             


Phe Arg Gly Leu Leu Lys Asp Ala Gln Thr Gln Leu Val Gly Leu His 
    610                 615                 620                 


Ala Lys Gln Glu Glu Leu Val Gln Gln Thr Val Ser Leu Thr Ser Thr 
625                 630                 635                 640 


Leu Gln Gln Asp Trp Arg Ser Met Gln Leu Asp Tyr Thr Thr Trp Thr 
                645                 650                 655     


Ala Leu Leu Ser Arg Ser Arg Gln Leu Thr Glu Lys Leu Thr Val Lys 
            660                 665                 670         


Ser Gln Gln Ala Leu Gln Glu Arg Asp Val Ala Ile Glu Glu Lys Gln 
        675                 680                 685             


Glu Val Ser Arg Val Leu Glu Gln Val Ser Ala Gln Leu Glu Glu Cys 
    690                 695                 700                 


Lys Gly Gln Thr Glu Gln Leu Glu Leu Glu Asn Ser Arg Leu Ala Thr 
705                 710                 715                 720 


Asp Leu Arg Ala Gln Leu Gln Ile Leu Ala Asn Met Asp Ser Gln Leu 
                725                 730                 735     


Lys Glu Leu Gln Ser Gln His Thr His Cys Ala Gln Asp Leu Ala Met 
            740                 745                 750         


Lys Asp Glu Leu Leu Cys Gln Leu Thr Gln Ser Asn Glu Glu Gln Ala 
        755                 760                 765             


Ala Gln Trp Gln Lys Glu Glu Met Ala Leu Lys His Met Gln Ala Glu 
    770                 775                 780                 


Leu Gln Gln Gln Gln Ala Val Leu Ala Lys Glu Val Arg Asp Leu Lys 
785                 790                 795                 800 


Glu Thr Leu Glu Phe Ala Asp Gln Glu Asn Gln Val Ala His Leu Glu 
                805                 810                 815     


Leu Gly Gln Val Glu Cys Gln Leu Lys Thr Thr Leu Glu Val Leu Arg 
            820                 825                 830         


Glu Arg Ser Leu Gln Cys Glu Asn Leu Lys Asp Thr Val Glu Asn Leu 
        835                 840                 845             


Thr Ala Lys Leu Ala Ser Thr Ile Ala Asp Asn Gln Glu Gln Asp Leu 
    850                 855                 860                 


Glu Lys Thr Arg Gln Tyr Ser Gln Lys Leu Gly Leu Leu Thr Glu Gln 
865                 870                 875                 880 


Leu Gln Ser Leu Thr Leu Phe Leu Gln Thr Lys Leu Lys Glu Lys Thr 
                885                 890                 895     


Glu Gln Glu Thr Leu Leu Leu Ser Thr Ala Cys Pro Pro Thr Gln Glu 
            900                 905                 910         


His Pro Leu Pro Asn Asp Arg Thr Phe Leu Gly Ser Ile Leu Thr Ala 
        915                 920                 925             


Val Ala Asp Glu Glu Pro Glu Ser Thr Pro Val Pro Leu Leu Gly Ser 
    930                 935                 940                 


Asp Lys Ser Ala Phe Thr Arg Val Ala Ser Met Val Ser Leu Gln Pro 
945                 950                 955                 960 


Ala Glu Thr Pro Gly Met Glu Glu Ser Leu Ala Glu Met Ser Ile Met 
                965                 970                 975     


Thr Thr Glu Leu Gln Ser Leu Cys Ser Leu Leu Gln Glu Ser Lys Glu 
            980                 985                 990         


Glu Ala Ile Arg Thr Leu Gln Arg  Lys Ile Cys Glu Leu  Gln Ala Arg 
        995                 1000                 1005             


Leu Gln  Ala Gln Glu Glu Gln  His Gln Glu Val Gln  Lys Ala Lys 
    1010                 1015                 1020             


Glu Ala  Asp Ile Glu Lys Leu  Asn Gln Ala Leu Cys  Leu Arg Tyr 
    1025                 1030                 1035             


Lys Asn  Glu Lys Glu Leu Gln  Glu Val Ile Gln Gln  Gln Asn Glu 
    1040                 1045                 1050             


Lys Ile  Leu Glu Gln Ile Asp  Lys Ser Gly Glu Leu  Ile Ser Leu 
    1055                 1060                 1065             


Arg Glu  Glu Val Thr His Leu  Thr Arg Ser Leu Arg  Arg Ala Glu 
    1070                 1075                 1080             


Thr Glu  Thr Lys Val Leu Gln  Glu Ala Leu Ala Gly  Gln Leu Asp 
    1085                 1090                 1095             


Ser Asn  Cys Gln Pro Met Ala  Thr Asn Trp Ile Gln  Glu Lys Val 
    1100                 1105                 1110             


Trp Leu  Ser Gln Glu Val Asp  Lys Leu Arg Val Met  Phe Leu Glu 
    1115                 1120                 1125             


Met Lys  Asn Glu Lys Glu Lys  Leu Met Ile Lys Phe  Gln Ser His 
    1130                 1135                 1140             


Arg Asn  Ile Leu Glu Glu Asn  Leu Arg Arg Ser Asp  Lys Glu Leu 
    1145                 1150                 1155             


Glu Lys  Leu Asp Asp Ile Val  Gln His Ile Tyr Lys  Thr Leu Leu 
    1160                 1165                 1170             


Ser Ile  Pro Glu Val Val Arg  Gly Cys Lys Glu Leu  Gln Gly Leu 
    1175                 1180                 1185             


Leu Glu  Phe Leu Ser 
    1190             


<210> 5444
<211> 3046
<212> PRT
<213> Homo sapiens

<400> 5444
Met Arg Gly Arg Arg Gly Arg Pro Pro Lys Gln Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Arg Cys Ala Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Thr 
            20                  25                  30          


Ser Gly Pro Ile Gly Gly Leu Arg Ser Arg His Arg Gly Ser Ser Arg 
        35                  40                  45              


Gly Arg Trp Ala Ala Ala Gln Ala Glu Val Ala Pro Lys Thr Arg Leu 
    50                  55                  60                  


Ser Ser Pro Arg Gly Gly Ser Ser Ser Arg Arg Lys Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Ser Thr Ser Ala Pro Gly Arg Gly Gly Arg Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Thr Gly Gly Gly Gly Gly Gly Gly His Leu Ala 
            100                 105                 110         


Arg Thr Thr Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp Asp 
        115                 120                 125             


His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Thr Gln Asp Ser Glu Asp 
145                 150                 155                 160 


Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr Pro 
                165                 170                 175     


Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Thr Glu Ser 
            180                 185                 190         


Ser Phe Arg Ser His Ser Thr Tyr Ser Ser Thr Pro Gly Arg Arg Lys 
        195                 200                 205             


Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp Ile 
    210                 215                 220                 


Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro Asn 
225                 230                 235                 240 


Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn Phe 
                245                 250                 255     


Gly Thr Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys Ala 
            260                 265                 270         


Ala Leu Val Ser Gln Glu Gln Cys Thr Leu Met Ala Glu Met His Val 
        275                 280                 285             


Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Thr Ser Asn Thr Thr 
    290                 295                 300                 


Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Thr Leu Tyr Phe 
305                 310                 315                 320 


Ile Asp Gly Met Thr Trp Pro Glu Val Leu Arg Val Tyr Cys Glu Ser 
                325                 330                 335     


Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp Tyr 
            340                 345                 350         


Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu Val 
        355                 360                 365             


Asp Gln Phe Leu Thr Thr Asn Ile Ala Arg Glu Glu Leu Met Ser Glu 
    370                 375                 380                 


Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Cys Cys Glu Thr Cys Ser Ala Val Tyr His Leu Glu Cys 
                405                 410                 415     


Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys Glu 
            420                 425                 430         


Val Cys Val Ala His Lys Val Pro Gly Val Thr Asp Cys Val Ala Glu 
        435                 440                 445             


Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr Asp 
    450                 455                 460                 


Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile Glu 
465                 470                 475                 480 


Glu Asp Thr Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser Thr 
                485                 490                 495     


Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr Trp 
            500                 505                 510         


Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile His 
        515                 520                 525             


Arg His Met Asp Ile Thr Glu Asp Leu Thr Asn Lys Ala Arg Gly Ser 
    530                 535                 540                 


Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu Thr 
                565                 570                 575     


Glu Lys Asp Lys Asn Glu Thr Glu Asn Asp Ser Lys Asp Ala Glu Lys 
            580                 585                 590         


Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp Asp 
        595                 600                 605             


Lys Thr Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Glu Pro Thr 
    610                 615                 620                 


Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala Asn Leu Gly Asp Asn 
625                 630                 635                 640 


Thr Thr Asn Ala Thr Ser Glu Glu Thr Ser Pro Ser Glu Gly Arg Ser 
                645                 650                 655     


Pro Val Gly Cys Leu Ser Glu Thr Pro Asp Ser Ser Asn Met Ala Glu 
            660                 665                 670         


Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val Pro Glu Glu Pro Asn 
        675                 680                 685             


Lys Thr Cys Glu Ser Ser Asn Thr Ser Ala Thr Thr Thr Ser Ile Gln 
    690                 695                 700                 


Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser Glu Leu Asn Ser Ser Gln 
705                 710                 715                 720 


Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro Glu Asn Gly Glu Arg Glu 
                725                 730                 735     


Ser His Thr Pro Val Ser Ile Gln Glu Glu Ile Val Gly Asp Phe Lys 
            740                 745                 750         


Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala Gly Lys 
        755                 760                 765             


Gly Ala Ser Gly Ser Thr Arg Ile Ile Thr Arg Leu Arg Asn Pro Asp 
    770                 775                 780                 


Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala Ala His 
785                 790                 795                 800 


Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val Val Asn 
                805                 810                 815     


Ser Gln Gly Glu Ile Ser Arg Leu Ser Thr Lys Lys Glu Val Ile Met 
            820                 825                 830         


Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly Lys Tyr 
        835                 840                 845             


Arg Val Tyr His Asn Gln Tyr Ser Thr Asn Ser Phe Ala Leu Asn Lys 
    850                 855                 860                 


His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala His Lys 
865                 870                 875                 880 


Phe Cys Leu Thr Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser Val His 
                885                 890                 895     


Gly Ser Lys Val Leu Thr Ile Ser Thr Leu Arg Leu Thr Ile Thr Gln 
            900                 905                 910         


Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His Pro Asn Trp Ala Ser 
        915                 920                 925             


His Arg Ala Asn Trp Ile Lys Ala Val Gln Met Cys Ser Lys Pro Arg 
    930                 935                 940                 


Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys Ala Val Lys Pro Val 
945                 950                 955                 960 


Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly His Thr Arg Leu His 
                965                 970                 975     


Arg Met Thr Ser Ile Glu Arg Glu Glu Lys Glu Lys Val Lys Lys Lys 
            980                 985                 990         


Glu Lys Lys Gln Glu Glu Glu Glu  Thr Met Gln Gln Ala  Thr Trp Val 
        995                 1000                 1005             


Lys Tyr  Thr Phe Pro Val Lys  His Gln Val Trp Lys  Gln Lys Gly 
    1010                 1015                 1020             


Glu Glu  Tyr Arg Val Thr Gly  Tyr Gly Gly Trp Ser  Trp Ile Ser 
    1025                 1030                 1035             


Lys Thr  His Val Tyr Arg Phe  Val Pro Lys Leu Pro  Gly Asn Thr 
    1040                 1045                 1050             


Asn Val  Asn Tyr Arg Lys Ser  Leu Glu Gly Thr Lys  Asn Asn Met 
    1055                 1060                 1065             


Asp Glu  Asn Met Asp Glu Ser  Asp Lys Arg Lys Cys  Ser Arg Ser 
    1070                 1075                 1080             


Pro Lys  Lys Ile Lys Ile Glu  Pro Asp Ser Glu Lys  Asp Glu Val 
    1085                 1090                 1095             


Lys Gly  Ser Asp Ala Ala Lys  Gly Ala Asp Gln Asn  Glu Met Asp 
    1100                 1105                 1110             


Ile Ser  Lys Ile Thr Glu Lys  Lys Asp Gln Asp Val  Lys Glu Leu 
    1115                 1120                 1125             


Leu Asp  Ser Asp Ser Asp Lys  Pro Cys Lys Glu Glu  Pro Met Glu 
    1130                 1135                 1140             


Val Asp  Asp Asp Met Lys Thr  Glu Ser His Val Asn  Cys Gln Glu 
    1145                 1150                 1155             


Ser Ser  Gln Val Asp Val Val  Asn Val Ser Glu Gly  Phe His Leu 
    1160                 1165                 1170             


Arg Thr  Ser Tyr Lys Lys Lys  Thr Lys Ser Ser Lys  Leu Asp Gly 
    1175                 1180                 1185             


Leu Leu  Glu Arg Arg Ile Lys  Gln Phe Thr Leu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Arg Leu  Glu Lys Ile Lys Leu  Glu Gly Gly Ile Lys  Gly Ile Gly 
    1205                 1210                 1215             


Lys Thr  Ser Thr Asn Ser Ser  Lys Asn Leu Ser Glu  Ser Pro Val 
    1220                 1225                 1230             


Ile Thr  Lys Ala Lys Glu Gly  Cys Gln Ser Asp Ser  Met Arg Gln 
    1235                 1240                 1245             


Glu Gln  Ser Pro Asn Ala Asn  Asn Asp Gln Pro Glu  Asp Leu Ile 
    1250                 1255                 1260             


Gln Gly  Cys Ser Glu Ser Asp  Ser Ser Val Leu Arg  Met Ser Asp 
    1265                 1270                 1275             


Pro Ser  His Thr Thr Asn Lys  Leu Tyr Pro Lys Asp  Arg Val Leu 
    1280                 1285                 1290             


Asp Asp  Val Ser Ile Arg Ser  Pro Glu Thr Lys Cys  Pro Lys Gln 
    1295                 1300                 1305             


Asn Ser  Ile Glu Asn Asp Ile  Glu Glu Lys Val Ser  Asp Leu Ala 
    1310                 1315                 1320             


Ser Arg  Gly Gln Glu Pro Ser  Lys Ser Lys Thr Lys  Gly Asn Asp 
    1325                 1330                 1335             


Phe Phe  Ile Asp Asp Ser Lys  Leu Ala Ser Ala Asp  Asp Ile Gly 
    1340                 1345                 1350             


Thr Leu  Ile Cys Lys Asn Lys  Lys Pro Leu Ile Gln  Glu Glu Ser 
    1355                 1360                 1365             


Asp Thr  Ile Val Ser Ser Ser  Lys Ser Ala Leu His  Ser Ser Val 
    1370                 1375                 1380             


Pro Lys  Ser Thr Asn Asp Arg  Asp Ala Thr Pro Leu  Ser Arg Ala 
    1385                 1390                 1395             


Met Asp  Phe Glu Gly Lys Leu  Gly Cys Asp Ser Glu  Ser Asn Ser 
    1400                 1405                 1410             


Thr Leu  Glu Asn Ser Ser Asp  Thr Val Ser Ile Gln  Asp Ser Ser 
    1415                 1420                 1425             


Glu Glu  Asp Met Ile Val Gln  Asn Ser Asn Glu Ser  Ile Ser Glu 
    1430                 1435                 1440             


Gln Phe  Arg Thr Arg Glu Gln  Asp Val Glu Val Leu  Glu Pro Leu 
    1445                 1450                 1455             


Lys Cys  Glu Leu Val Ser Gly  Glu Ser Thr Gly Asn  Cys Glu Asp 
    1460                 1465                 1470             


Arg Leu  Pro Val Lys Gly Thr  Glu Ala Asn Gly Lys  Lys Pro Ser 
    1475                 1480                 1485             


Gln Gln  Lys Lys Leu Glu Glu  Arg Pro Val Asn Lys  Cys Ser Asp 
    1490                 1495                 1500             


Gln Ile  Lys Leu Lys Asn Thr  Thr Asp Lys Lys Asn  Asn Glu Asn 
    1505                 1510                 1515             


Arg Glu  Ser Glu Lys Lys Gly  Gln Arg Thr Ser Thr  Phe Gln Ile 
    1520                 1525                 1530             


Asn Gly  Lys Asp Asn Lys Pro  Lys Ile Tyr Leu Lys  Gly Glu Cys 
    1535                 1540                 1545             


Leu Lys  Glu Ile Ser Glu Ser  Arg Val Val Ser Gly  Asn Val Glu 
    1550                 1555                 1560             


Pro Lys  Val Asn Asn Ile Asn  Lys Ile Ile Pro Glu  Asn Asp Ile 
    1565                 1570                 1575             


Lys Ser  Leu Thr Val Lys Glu  Ser Ala Ile Arg Pro  Phe Ile Asn 
    1580                 1585                 1590             


Gly Asp  Val Ile Met Glu Asp  Phe Asn Glu Arg Asn  Ser Ser Glu 
    1595                 1600                 1605             


Thr Lys  Ser His Leu Leu Ser  Ser Ser Asp Ala Glu  Gly Asn Tyr 
    1610                 1615                 1620             


Arg Asp  Ser Leu Glu Thr Leu  Pro Ser Thr Lys Glu  Ser Asp Ser 
    1625                 1630                 1635             


Thr Gln  Thr Thr Thr Pro Ser  Ala Ser Cys Pro Glu  Ser Asn Ser 
    1640                 1645                 1650             


Val Asn  Gln Val Glu Asp Met  Glu Ile Glu Thr Ser  Glu Val Lys 
    1655                 1660                 1665             


Lys Val  Thr Ser Ser Pro Ile  Thr Ser Glu Glu Glu  Ser Asn Leu 
    1670                 1675                 1680             


Ser Asn  Asp Phe Ile Asp Glu  Asn Gly Leu Pro Ile  Asn Lys Asn 
    1685                 1690                 1695             


Glu Asn  Val Asn Gly Glu Ser  Lys Arg Lys Thr Val  Ile Thr Glu 
    1700                 1705                 1710             


Val Thr  Thr Met Thr Ser Thr  Val Ala Thr Glu Ser  Lys Thr Val 
    1715                 1720                 1725             


Ile Lys  Val Glu Lys Gly Asp  Lys Gln Thr Val Val  Ser Ser Thr 
    1730                 1735                 1740             


Glu Asn  Cys Ala Lys Ser Thr  Val Thr Thr Thr Thr  Thr Thr Val 
    1745                 1750                 1755             


Thr Lys  Leu Ser Thr Pro Ser  Thr Gly Gly Ser Val  Asp Ile Ile 
    1760                 1765                 1770             


Ser Val  Lys Glu Gln Ser Lys  Thr Val Val Thr Thr  Thr Val Thr 
    1775                 1780                 1785             


Asp Ser  Leu Thr Thr Thr Gly  Gly Thr Leu Val Thr  Ser Met Thr 
    1790                 1795                 1800             


Val Ser  Lys Glu Tyr Ser Thr  Arg Asp Lys Val Lys  Leu Met Lys 
    1805                 1810                 1815             


Phe Ser  Arg Pro Lys Lys Thr  Arg Ser Gly Thr Ala  Leu Pro Ser 
    1820                 1825                 1830             


Tyr Arg  Lys Phe Val Thr Lys  Ser Ser Lys Lys Ser  Ile Phe Val 
    1835                 1840                 1845             


Leu Pro  Asn Asp Asp Leu Lys  Lys Leu Ala Arg Lys  Gly Gly Ile 
    1850                 1855                 1860             


Arg Glu  Val Pro Tyr Phe Asn  Tyr Asn Ala Lys Pro  Ala Leu Asp 
    1865                 1870                 1875             


Ile Trp  Pro Tyr Pro Ser Pro  Arg Pro Thr Phe Gly  Ile Thr Trp 
    1880                 1885                 1890             


Arg Tyr  Arg Leu Gln Thr Val  Lys Ser Leu Ala Gly  Val Ser Leu 
    1895                 1900                 1905             


Met Leu  Arg Leu Leu Trp Ala  Ser Leu Arg Trp Asp  Asp Met Ala 
    1910                 1915                 1920             


Ala Lys  Ala Pro Pro Gly Gly  Gly Thr Thr Arg Thr  Glu Thr Ser 
    1925                 1930                 1935             


Glu Thr  Glu Ile Thr Thr Thr  Glu Ile Ile Lys Arg  Arg Asp Val 
    1940                 1945                 1950             


Gly Pro  Tyr Gly Ile Arg Ser  Glu Tyr Cys Ile Arg  Lys Ile Ile 
    1955                 1960                 1965             


Cys Pro  Ile Gly Val Pro Glu  Thr Pro Lys Glu Thr  Pro Thr Pro 
    1970                 1975                 1980             


Gln Arg  Lys Gly Leu Arg Ser  Ser Ala Leu Arg Pro  Lys Arg Pro 
    1985                 1990                 1995             


Glu Thr  Pro Lys Gln Thr Gly  Pro Val Ile Ile Glu  Thr Trp Val 
    2000                 2005                 2010             


Ala Glu  Glu Glu Leu Glu Leu  Trp Glu Ile Arg Ala  Phe Ala Glu 
    2015                 2020                 2025             


Arg Val  Glu Lys Glu Lys Ala  Gln Ala Val Glu Gln  Gln Ala Lys 
    2030                 2035                 2040             


Lys Arg  Leu Glu Gln Gln Lys  Pro Thr Val Ile Ala  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Pro Thr Ser Ser Thr  Thr Ser Thr Ile Ser  Pro Ala Gln 
    2060                 2065                 2070             


Lys Val  Met Val Ala Pro Ile  Ser Gly Ser Val Thr  Thr Gly Thr 
    2075                 2080                 2085             


Lys Met  Val Leu Thr Thr Lys  Val Gly Ser Pro Ala  Thr Val Thr 
    2090                 2095                 2100             


Phe Gln  Gln Asn Lys Asn Phe  His Gln Thr Phe Ala  Thr Trp Val 
    2105                 2110                 2115             


Lys Gln  Gly Gln Ser Asn Ser  Gly Val Val Gln Val  Gln Gln Lys 
    2120                 2125                 2130             


Val Leu  Gly Ile Ile Pro Ser  Ser Thr Gly Thr Ser  Gln Gln Thr 
    2135                 2140                 2145             


Phe Thr  Ser Phe Gln Pro Arg  Thr Ala Thr Val Thr  Ile Arg Pro 
    2150                 2155                 2160             


Asn Thr  Ser Gly Ser Gly Gly  Thr Thr Ser Asn Ser  Gln Val Ile 
    2165                 2170                 2175             


Thr Gly  Pro Gln Ile Arg Pro  Gly Met Thr Val Ile  Arg Thr Pro 
    2180                 2185                 2190             


Leu Gln  Gln Ser Thr Leu Gly  Lys Ala Ile Ile Arg  Thr Pro Val 
    2195                 2200                 2205             


Met Val  Gln Pro Gly Ala Pro  Gln Gln Val Met Thr  Gln Ile Ile 
    2210                 2215                 2220             


Arg Gly  Gln Pro Val Ser Thr  Ala Val Ser Ala Pro  Asn Thr Val 
    2225                 2230                 2235             


Ser Ser  Thr Pro Gly Gln Lys  Ser Leu Thr Ser Ala  Thr Ser Thr 
    2240                 2245                 2250             


Ser Asn  Ile Gln Ser Ser Ala  Ser Gln Pro Pro Arg  Pro Gln Gln 
    2255                 2260                 2265             


Gly Gln  Val Lys Leu Thr Met  Ala Gln Leu Thr Gln  Leu Thr Gln 
    2270                 2275                 2280             


Gly His  Gly Gly Asn Gln Gly  Leu Thr Val Val Ile  Gln Gly Gln 
    2285                 2290                 2295             


Gly Gln  Thr Thr Gly Gln Leu  Gln Leu Ile Pro Gln  Gly Val Thr 
    2300                 2305                 2310             


Val Leu  Pro Gly Pro Gly Gln  Gln Leu Met Gln Ala  Ala Met Pro 
    2315                 2320                 2325             


Asn Gly  Thr Val Gln Arg Phe  Leu Phe Thr Pro Leu  Ala Thr Thr 
    2330                 2335                 2340             


Ala Thr  Thr Ala Ser Thr Thr  Thr Thr Thr Val Ser  Thr Thr Ala 
    2345                 2350                 2355             


Ala Gly  Thr Gly Glu Gln Arg  Gln Ser Lys Leu Ser  Pro Gln Met 
    2360                 2365                 2370             


Gln Val  His Gln Asp Lys Thr  Leu Pro Pro Ala Gln  Ser Ser Ser 
    2375                 2380                 2385             


Val Gly  Pro Ala Glu Ala Gln  Pro Gln Thr Ala Gln  Pro Ser Ala 
    2390                 2395                 2400             


Gln Pro  Gln Pro Gln Thr Gln  Pro Gln Ser Pro Ala  Gln Pro Glu 
    2405                 2410                 2415             


Val Gln  Thr Gln Pro Glu Val  Gln Thr Gln Thr Thr  Val Ser Ser 
    2420                 2425                 2430             


His Val  Pro Ser Glu Ala Gln  Pro Thr His Ala Gln  Ser Ser Lys 
    2435                 2440                 2445             


Pro Gln  Val Ala Ala Gln Ser  Gln Pro Gln Ser Asn  Val Gln Gly 
    2450                 2455                 2460             


Gln Ser  Pro Val Arg Val Gln  Ser Pro Ser Gln Thr  Arg Ile Arg 
    2465                 2470                 2475             


Pro Ser  Thr Pro Ser Gln Leu  Ser Pro Gly Gln Gln  Ser Gln Val 
    2480                 2485                 2490             


Gln Thr  Thr Thr Ser Gln Pro  Ile Pro Ile Gln Pro  His Thr Ser 
    2495                 2500                 2505             


Leu Gln  Ile Pro Ser Gln Gly  Gln Pro Gln Ser Gln  Pro Gln Val 
    2510                 2515                 2520             


Gln Ser  Ser Thr Gln Thr Leu  Ser Ser Gly Gln Thr  Leu Asn Gln 
    2525                 2530                 2535             


Val Thr  Val Ser Ser Pro Ser  Arg Pro Gln Leu Gln  Ile Gln Gln 
    2540                 2545                 2550             


Pro Gln  Pro Gln Val Ile Ala  Val Pro Gln Leu Gln  Gln Gln Val 
    2555                 2560                 2565             


Gln Val  Leu Ser Gln Ile Gln  Ser Gln Val Val Ala  Gln Ile Gln 
    2570                 2575                 2580             


Ala Gln  Gln Ser Gly Val Pro  Gln Gln Ile Lys Leu  Gln Leu Pro 
    2585                 2590                 2595             


Ile Gln  Ile Gln Gln Ser Ser  Ala Val Gln Thr His  Gln Ile Gln 
    2600                 2605                 2610             


Asn Val  Val Thr Val Gln Ala  Ala Ser Val Gln Glu  Gln Leu Gln 
    2615                 2620                 2625             


Arg Val  Gln Gln Leu Arg Asp  Gln Gln Gln Lys Lys  Lys Gln Gln 
    2630                 2635                 2640             


Gln Ile  Glu Ile Lys Arg Glu  His Thr Leu Gln Ala  Ser Asn Gln 
    2645                 2650                 2655             


Ser Glu  Ile Ile Gln Lys Gln  Val Val Met Lys His  Asn Ala Val 
    2660                 2665                 2670             


Ile Glu  His Leu Lys Gln Lys  Lys Ser Met Thr Pro  Ala Glu Arg 
    2675                 2680                 2685             


Glu Glu  Asn Gln Arg Met Ile  Val Cys Asn Gln Val  Met Lys Tyr 
    2690                 2695                 2700             


Ile Leu  Asp Lys Ile Asp Lys  Glu Glu Lys Gln Ala  Ala Lys Lys 
    2705                 2710                 2715             


Arg Lys  Arg Glu Glu Ser Val  Glu Gln Lys Arg Ser  Lys Gln Asn 
    2720                 2725                 2730             


Ala Thr  Lys Leu Ser Ala Leu  Leu Phe Lys His Lys  Glu Gln Leu 
    2735                 2740                 2745             


Arg Ala  Glu Ile Leu Lys Lys  Arg Ala Leu Leu Asp  Lys Asp Leu 
    2750                 2755                 2760             


Gln Ile  Glu Val Gln Glu Glu  Leu Lys Arg Asp Leu  Lys Ile Lys 
    2765                 2770                 2775             


Lys Glu  Lys Asp Leu Met Gln  Leu Ala Gln Ala Thr  Ala Val Ala 
    2780                 2785                 2790             


Ala Pro  Cys Pro Pro Val Thr  Pro Ala Pro Pro Ala  Pro Pro Ala 
    2795                 2800                 2805             


Pro Pro  Pro Ser Pro Pro Pro  Pro Pro Ala Val Gln  His Thr Gly 
    2810                 2815                 2820             


Leu Leu  Ser Thr Pro Thr Leu  Pro Ala Ala Ser Gln  Lys Arg Lys 
    2825                 2830                 2835             


Arg Glu  Glu Glu Lys Asp Ser  Ser Ser Lys Ser Lys  Lys Lys Lys 
    2840                 2845                 2850             


Met Ile  Ser Thr Thr Ser Lys  Glu Thr Lys Lys Asp  Thr Lys Leu 
    2855                 2860                 2865             


Tyr Cys  Ile Cys Lys Thr Pro  Tyr Asp Glu Ser Lys  Phe Tyr Ile 
    2870                 2875                 2880             


Gly Cys  Asp Arg Cys Gln Asn  Trp Tyr His Gly Arg  Cys Val Gly 
    2885                 2890                 2895             


Ile Leu  Gln Ser Glu Ala Glu  Leu Ile Asp Glu Tyr  Val Cys Pro 
    2900                 2905                 2910             


Gln Cys  Gln Ser Thr Glu Asp  Ala Met Thr Val Leu  Thr Pro Leu 
    2915                 2920                 2925             


Thr Glu  Lys Asp Tyr Glu Gly  Leu Lys Arg Val Leu  Arg Ser Leu 
    2930                 2935                 2940             


Gln Ala  His Lys Met Ala Trp  Pro Phe Leu Glu Pro  Val Asp Pro 
    2945                 2950                 2955             


Asn Asp  Ala Pro Asp Tyr Tyr  Gly Val Ile Lys Glu  Pro Met Asp 
    2960                 2965                 2970             


Leu Ala  Thr Met Glu Glu Arg  Val Gln Arg Arg Tyr  Tyr Glu Lys 
    2975                 2980                 2985             


Leu Thr  Glu Phe Val Ala Asp  Met Thr Lys Ile Phe  Asp Asn Cys 
    2990                 2995                 3000             


Arg Tyr  Tyr Asn Pro Ser Asp  Ser Pro Phe Tyr Gln  Cys Ala Glu 
    3005                 3010                 3015             


Val Leu  Glu Ser Phe Phe Val  Gln Lys Leu Lys Gly  Phe Lys Ala 
    3020                 3025                 3030             


Ser Arg  Ser His Asn Asn Lys  Leu Gln Ser Thr Ala  Ser 
    3035                 3040                 3045     


<210> 5445
<211> 308
<212> PRT
<213> Homo sapiens

<400> 5445
Met Ala Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr 
1               5                   10                  15      


Ser Ile Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu 
            20                  25                  30          


Gly Asp Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr 
        35                  40                  45              


Lys Ala Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg 
    50                  55                  60                  


Lys Phe Pro Lys Leu Thr Ile Ile Gly Glu Glu Asp Leu Pro Ser Glu 
65                  70                  75                  80  


Glu Val Asp Gln Glu Leu Ile Glu Asp Ser Gln Trp Glu Glu Ile Leu 
                85                  90                  95      


Lys Gln Pro Cys Pro Ser Gln Tyr Ser Ala Ile Lys Glu Glu Asp Leu 
            100                 105                 110         


Val Val Trp Val Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly 
        115                 120                 125             


Leu Leu Asp Asn Val Thr Val Leu Ile Gly Ile Ala Tyr Glu Gly Lys 
    130                 135                 140                 


Ala Ile Ala Gly Val Ile Asn Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly 
145                 150                 155                 160 


Pro Asp Ala Val Leu Gly Arg Thr Ile Trp Gly Val Leu Gly Leu Gly 
                165                 170                 175     


Ala Phe Gly Phe Gln Leu Lys Glu Val Pro Ala Gly Lys His Ile Ile 
            180                 185                 190         


Thr Thr Thr Arg Ser His Ser Asn Lys Leu Val Thr Asp Cys Val Ala 
        195                 200                 205             


Ala Met Asn Pro Asp Ala Val Leu Arg Val Gly Gly Ala Gly Asn Lys 
    210                 215                 220                 


Ile Ile Gln Leu Ile Glu Gly Lys Ala Ser Ala Tyr Val Phe Ala Ser 
225                 230                 235                 240 


Pro Gly Cys Lys Lys Trp Asp Thr Cys Ala Pro Glu Val Ile Leu His 
                245                 250                 255     


Ala Val Gly Gly Lys Leu Thr Asp Ile His Gly Asn Val Leu Gln Tyr 
            260                 265                 270         


His Lys Asp Val Lys His Met Asn Ser Ala Gly Val Leu Ala Thr Leu 
        275                 280                 285             


Arg Asn Tyr Asp Tyr Tyr Ala Ser Arg Val Pro Glu Ser Ile Lys Asn 
    290                 295                 300                 


Ala Leu Val Pro 
305             


<210> 5446
<211> 403
<212> PRT
<213> Homo sapiens

<400> 5446
Met Ser Gly Ser Asp Gly Gly Leu Glu Glu Glu Pro Glu Leu Ser Ile 
1               5                   10                  15      


Thr Leu Thr Leu Arg Met Leu Met His Gly Lys Glu Val Gly Ser Ile 
            20                  25                  30          


Ile Gly Lys Lys Gly Glu Thr Val Lys Arg Ile Arg Glu Gln Ser Ser 
        35                  40                  45              


Ala Arg Ile Thr Ile Ser Glu Gly Ser Cys Pro Glu Arg Ile Thr Thr 
    50                  55                  60                  


Ile Thr Gly Ser Thr Ala Ala Val Phe His Ala Val Ser Met Ile Ala 
65                  70                  75                  80  


Phe Lys Leu Asp Glu Asp Leu Cys Ala Ala Pro Ala Asn Gly Gly Asn 
                85                  90                  95      


Val Ser Arg Pro Pro Val Thr Leu Arg Leu Val Ile Pro Ala Ser Gln 
            100                 105                 110         


Cys Gly Ser Leu Ile Gly Lys Ala Gly Thr Lys Ile Lys Glu Ile Arg 
        115                 120                 125             


Glu Thr Thr Gly Ala Gln Val Gln Val Ala Gly Asp Leu Leu Pro Asn 
    130                 135                 140                 


Ser Thr Glu Arg Ala Val Thr Val Ser Gly Val Pro Asp Ala Ile Ile 
145                 150                 155                 160 


Leu Cys Val Arg Gln Ile Cys Ala Val Ile Leu Glu Ser Pro Pro Lys 
                165                 170                 175     


Gly Ala Thr Ile Pro Tyr His Pro Ser Leu Ser Leu Gly Thr Val Leu 
            180                 185                 190         


Leu Ser Ala Asn Gln Gly Phe Ser Val Gln Gly Gln Tyr Gly Ala Val 
        195                 200                 205             


Thr Pro Ala Glu Val Thr Lys Leu Gln Gln Leu Ser Ser His Ala Val 
    210                 215                 220                 


Pro Phe Ala Thr Pro Ser Val Val Pro Gly Leu Asp Pro Gly Thr Gln 
225                 230                 235                 240 


Thr Ser Ser Gln Glu Phe Leu Val Pro Asn Asp Leu Ile Gly Cys Val 
                245                 250                 255     


Ile Gly Arg Gln Gly Ser Lys Ile Ser Glu Ile Arg Gln Met Ser Gly 
            260                 265                 270         


Ala His Ile Lys Ile Gly Asn Gln Ala Glu Gly Ala Gly Glu Arg His 
        275                 280                 285             


Val Thr Ile Thr Gly Ser Pro Val Ser Ile Ala Leu Ala Gln Tyr Leu 
    290                 295                 300                 


Ile Thr Ala Cys Leu Glu Thr Ala Lys Ser Thr Ser Gly Gly Thr Pro 
305                 310                 315                 320 


Ser Ser Ala Pro Ala Asp Leu Pro Ala Pro Phe Ser Pro Pro Leu Thr 
                325                 330                 335     


Ala Leu Pro Thr Ala Pro Pro Gly Leu Leu Gly Thr Pro Tyr Ala Ile 
            340                 345                 350         


Ser Leu Ser Asn Phe Ile Gly Leu Lys Pro Met Pro Phe Leu Ala Leu 
        355                 360                 365             


Pro Pro Ala Ser Pro Gly Pro Pro Pro Gly Leu Ala Ala Tyr Thr Ala 
    370                 375                 380                 


Lys Met Ala Ala Ala Asn Gly Ser Lys Lys Ala Glu Arg Gln Lys Phe 
385                 390                 395                 400 


Ser Pro Tyr 
            


<210> 5447
<211> 217
<212> PRT
<213> Homo sapiens

<400> 5447
Met Ser Ser Lys Val Ser Arg Asp Thr Leu Tyr Glu Ala Val Arg Glu 
1               5                   10                  15      


Val Leu His Gly Asn Gln Arg Lys Arg Arg Lys Phe Leu Glu Thr Val 
            20                  25                  30          


Glu Leu Gln Ile Ser Leu Lys Asn Tyr Asp Pro Gln Lys Asp Lys Arg 
        35                  40                  45              


Phe Ser Gly Thr Val Arg Leu Lys Ser Thr Pro Arg Pro Lys Phe Ser 
    50                  55                  60                  


Val Cys Val Leu Gly Asp Gln Gln His Cys Asp Glu Ala Lys Ala Val 
65                  70                  75                  80  


Asp Ile Pro His Met Asp Ile Glu Ala Leu Lys Lys Leu Asn Lys Asn 
                85                  90                  95      


Lys Lys Leu Val Lys Lys Leu Ala Lys Lys Tyr Asp Ala Phe Leu Ala 
            100                 105                 110         


Ser Glu Ser Leu Ile Lys Gln Ile Pro Arg Ile Leu Gly Pro Gly Leu 
        115                 120                 125             


Asn Lys Ala Gly Lys Phe Pro Ser Leu Leu Thr His Asn Glu Asn Met 
    130                 135                 140                 


Val Ala Lys Val Asp Glu Val Lys Ser Thr Ile Lys Phe Gln Met Lys 
145                 150                 155                 160 


Lys Val Leu Cys Leu Ala Val Ala Val Gly His Val Lys Met Thr Asp 
                165                 170                 175     


Asp Glu Leu Val Tyr Asn Ile His Leu Ala Val Asn Phe Leu Val Ser 
            180                 185                 190         


Leu Leu Lys Lys Asn Trp Gln Asn Val Arg Ala Leu Tyr Ile Lys Ser 
        195                 200                 205             


Thr Met Gly Lys Pro Gln Arg Leu Tyr 
    210                 215         


<210> 5448
<211> 1052
<212> PRT
<213> Homo sapiens

<400> 5448
Met Glu Gly Ser Glu Pro Val Ala Ala His Gln Gly Glu Glu Ala Ser 
1               5                   10                  15      


Cys Ser Ser Trp Gly Thr Gly Ser Thr Asn Lys Asn Leu Pro Ile Met 
            20                  25                  30          


Ser Thr Ala Ser Val Glu Ile Asp Asp Ala Leu Tyr Ser Arg Gln Arg 
        35                  40                  45              


Tyr Val Leu Gly Asp Thr Ala Met Gln Lys Met Ala Lys Ser His Val 
    50                  55                  60                  


Phe Leu Ser Gly Met Gly Gly Leu Gly Leu Glu Ile Ala Lys Asn Leu 
65                  70                  75                  80  


Val Leu Ala Gly Ile Lys Ala Val Thr Ile His Asp Thr Glu Lys Cys 
                85                  90                  95      


Gln Ala Trp Asp Leu Gly Thr Asn Phe Phe Leu Ser Glu Asp Asp Val 
            100                 105                 110         


Val Asn Lys Arg Asn Arg Ala Glu Ala Val Leu Lys His Ile Ala Glu 
        115                 120                 125             


Leu Asn Pro Tyr Val His Val Thr Ser Ser Ser Val Pro Phe Asn Glu 
    130                 135                 140                 


Thr Thr Asp Leu Ser Phe Leu Asp Lys Tyr Gln Cys Val Val Leu Thr 
145                 150                 155                 160 


Glu Met Lys Leu Pro Leu Gln Lys Lys Ile Asn Asp Phe Cys Arg Ser 
                165                 170                 175     


Gln Cys Pro Pro Ile Lys Phe Ile Ser Ala Asp Val His Gly Ile Trp 
            180                 185                 190         


Ser Arg Leu Phe Cys Asp Phe Gly Asp Glu Phe Glu Val Leu Asp Thr 
        195                 200                 205             


Thr Gly Glu Glu Pro Lys Glu Ile Phe Ile Ser Asn Ile Thr Gln Ala 
    210                 215                 220                 


Asn Pro Gly Ile Val Thr Cys Leu Glu Asn His Pro His Lys Leu Glu 
225                 230                 235                 240 


Thr Gly Gln Phe Leu Thr Phe Arg Glu Ile Asn Gly Met Thr Gly Leu 
                245                 250                 255     


Asn Gly Ser Ile Gln Gln Ile Thr Val Ile Ser Pro Phe Ser Phe Ser 
            260                 265                 270         


Ile Gly Asp Thr Thr Glu Leu Glu Pro Tyr Leu His Gly Gly Ile Ala 
        275                 280                 285             


Val Gln Val Lys Thr Pro Lys Thr Val Phe Phe Glu Ser Leu Glu Arg 
    290                 295                 300                 


Gln Leu Lys His Pro Lys Cys Leu Ile Val Asp Phe Ser Asn Pro Glu 
305                 310                 315                 320 


Ala Pro Leu Glu Ile His Thr Ala Met Leu Ala Leu Asp Gln Phe Gln 
                325                 330                 335     


Glu Lys Tyr Ser Arg Lys Pro Asn Val Gly Cys Gln Gln Asp Ser Glu 
            340                 345                 350         


Glu Leu Leu Lys Leu Ala Thr Ser Ile Ser Glu Thr Leu Glu Glu Lys 
        355                 360                 365             


Pro Asp Val Asn Ala Asp Ile Val His Trp Leu Ser Trp Thr Ala Gln 
    370                 375                 380                 


Gly Phe Leu Ser Pro Leu Ala Ala Ala Val Gly Gly Val Ala Ser Gln 
385                 390                 395                 400 


Glu Val Leu Lys Ala Val Thr Gly Lys Phe Ser Pro Leu Cys Gln Trp 
                405                 410                 415     


Leu Tyr Leu Glu Ala Ala Asp Ile Val Glu Ser Leu Gly Lys Pro Glu 
            420                 425                 430         


Cys Glu Glu Phe Leu Pro Arg Gly Asp Arg Tyr Asp Ala Leu Arg Ala 
        435                 440                 445             


Cys Ile Gly Asp Thr Leu Cys Gln Lys Leu Gln Asn Leu Asn Ile Phe 
    450                 455                 460                 


Leu Val Gly Cys Gly Ala Ile Gly Cys Glu Met Leu Lys Asn Phe Ala 
465                 470                 475                 480 


Leu Leu Gly Val Gly Thr Ser Lys Glu Lys Gly Met Ile Thr Val Thr 
                485                 490                 495     


Asp Pro Asp Leu Ile Glu Lys Ser Asn Leu Asn Arg Gln Phe Leu Phe 
            500                 505                 510         


Arg Pro His His Ile Gln Lys Pro Lys Ser Tyr Thr Ala Ala Asp Ala 
        515                 520                 525             


Thr Leu Lys Ile Asn Ser Gln Ile Lys Ile Asp Ala His Leu Asn Lys 
    530                 535                 540                 


Val Cys Pro Thr Thr Glu Thr Ile Tyr Asn Asp Glu Phe Tyr Thr Lys 
545                 550                 555                 560 


Gln Asp Val Ile Ile Thr Ala Leu Asp Asn Val Glu Ala Arg Arg Tyr 
                565                 570                 575     


Val Asp Ser Arg Cys Leu Ala Asn Leu Arg Pro Leu Leu Asp Ser Gly 
            580                 585                 590         


Thr Met Gly Thr Lys Gly His Thr Glu Val Ile Val Pro His Leu Thr 
        595                 600                 605             


Glu Ser Tyr Asn Ser His Arg Asp Pro Pro Glu Glu Glu Ile Pro Phe 
    610                 615                 620                 


Cys Thr Leu Lys Ser Phe Pro Ala Ala Ile Glu His Thr Ile Gln Trp 
625                 630                 635                 640 


Ala Arg Asp Lys Phe Glu Ser Ser Phe Ser His Lys Pro Ser Leu Phe 
                645                 650                 655     


Asn Lys Phe Trp Gln Thr Tyr Ser Ser Ala Glu Glu Val Leu Gln Lys 
            660                 665                 670         


Ile Gln Ser Gly His Ser Leu Glu Gly Cys Phe Gln Val Ile Lys Leu 
        675                 680                 685             


Leu Ser Arg Arg Pro Arg Asn Trp Ser Gln Cys Val Glu Leu Ala Arg 
    690                 695                 700                 


Leu Lys Phe Glu Lys Tyr Phe Asn His Lys Ala Leu Gln Leu Leu His 
705                 710                 715                 720 


Cys Phe Pro Leu Asp Ile Arg Leu Lys Asp Gly Ser Leu Phe Trp Gln 
                725                 730                 735     


Ser Pro Lys Arg Pro Pro Ser Pro Ile Lys Phe Asp Leu Asn Glu Pro 
            740                 745                 750         


Leu His Leu Ser Phe Leu Gln Asn Ala Ala Lys Leu Tyr Ala Thr Val 
        755                 760                 765             


Tyr Cys Ile Pro Phe Ala Glu Glu Asp Leu Ser Ala Asp Ala Leu Leu 
    770                 775                 780                 


Asn Ile Leu Ser Glu Val Lys Ile Gln Glu Phe Lys Pro Ser Asn Lys 
785                 790                 795                 800 


Val Val Gln Thr Asp Glu Thr Ala Arg Lys Pro Asp His Val Pro Ile 
                805                 810                 815     


Ser Ser Glu Asp Glu Arg Asn Ala Ile Phe Gln Leu Glu Lys Ala Ile 
            820                 825                 830         


Leu Ser Asn Glu Ala Thr Lys Ser Asp Leu Gln Met Ala Val Leu Ser 
        835                 840                 845             


Phe Glu Lys Asp Asp Asp His Asn Gly His Ile Asp Phe Ile Thr Ala 
    850                 855                 860                 


Ala Ser Asn Leu Arg Ala Lys Met Tyr Ser Ile Glu Pro Ala Asp Arg 
865                 870                 875                 880 


Phe Lys Thr Lys Arg Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr 
                885                 890                 895     


Thr Thr Ala Thr Val Ser Gly Leu Val Ala Leu Glu Met Ile Lys Val 
            900                 905                 910         


Thr Gly Gly Tyr Pro Phe Glu Ala Tyr Lys Asn Cys Phe Leu Asn Leu 
        915                 920                 925             


Ala Ile Pro Ile Val Val Phe Thr Glu Thr Thr Glu Val Arg Lys Thr 
    930                 935                 940                 


Lys Ile Arg Asn Gly Ile Ser Phe Thr Ile Trp Asp Arg Trp Thr Val 
945                 950                 955                 960 


His Gly Lys Glu Asp Phe Thr Leu Leu Asp Phe Ile Asn Ala Val Lys 
                965                 970                 975     


Glu Lys Tyr Gly Ile Glu Pro Thr Met Val Val Gln Gly Val Lys Met 
            980                 985                 990         


Leu Tyr Val Pro Val Met Pro Gly  His Ala Lys Arg Leu  Lys Leu Thr 
        995                 1000                 1005             


Met His  Lys Leu Val Lys Pro  Thr Thr Glu Lys Lys  Tyr Val Asp 
    1010                 1015                 1020             


Leu Thr  Val Ser Phe Ala Pro  Asp Ile Asp Gly Asp  Glu Asp Leu 
    1025                 1030                 1035             


Pro Gly  Pro Pro Val Arg Tyr  Tyr Phe Ser His Asp  Thr Asp 
    1040                 1045                 1050         


<210> 5449
<211> 377
<212> PRT
<213> Homo sapiens

<400> 5449
Met Leu Arg Leu Val Pro Thr Gly Ala Arg Ala Ile Val Asp Met Ser 
1               5                   10                  15      


Tyr Ala Arg His Phe Leu Asp Phe Gln Gly Ser Ala Ile Pro Gln Ala 
            20                  25                  30          


Met Gln Lys Leu Val Val Thr Arg Leu Ser Pro Asn Phe Arg Glu Ala 
        35                  40                  45              


Val Thr Leu Ser Arg Asp Cys Pro Val Pro Leu Pro Gly Asp Gly Asp 
    50                  55                  60                  


Leu Leu Val Arg Asn Arg Phe Val Gly Val Asn Ala Ser Asp Ile Asn 
65                  70                  75                  80  


Tyr Ser Ala Gly Arg Tyr Asp Pro Ser Val Lys Pro Pro Phe Asp Ile 
                85                  90                  95      


Gly Phe Glu Gly Ile Gly Glu Val Val Ala Leu Gly Leu Ser Ala Ser 
            100                 105                 110         


Ala Arg Tyr Thr Val Gly Gln Ala Val Ala Tyr Met Ala Pro Gly Ser 
        115                 120                 125             


Phe Ala Glu Tyr Thr Val Val Pro Ala Ser Ile Ala Thr Pro Val Pro 
    130                 135                 140                 


Ser Val Lys Pro Glu Tyr Leu Thr Leu Leu Val Ser Gly Thr Thr Ala 
145                 150                 155                 160 


Tyr Ile Ser Leu Lys Glu Leu Gly Gly Leu Ser Glu Gly Lys Lys Val 
                165                 170                 175     


Leu Val Thr Ala Ala Ala Gly Gly Thr Gly Gln Phe Ala Met Gln Leu 
            180                 185                 190         


Ser Lys Lys Ala Lys Cys His Val Ile Gly Thr Cys Ser Ser Asp Glu 
        195                 200                 205             


Lys Ser Ala Phe Leu Lys Ser Leu Gly Cys Asp Arg Pro Ile Asn Tyr 
    210                 215                 220                 


Lys Thr Glu Pro Val Gly Thr Val Leu Lys Gln Glu Tyr Pro Glu Gly 
225                 230                 235                 240 


Val Asp Val Val Tyr Glu Ser Val Gly Gly Ala Met Phe Asp Leu Ala 
                245                 250                 255     


Val Asp Ala Leu Ala Thr Lys Gly Arg Leu Ile Val Ile Gly Phe Ile 
            260                 265                 270         


Ser Gly Tyr Gln Thr Pro Thr Gly Leu Ser Pro Val Lys Ala Gly Thr 
        275                 280                 285             


Leu Pro Ala Lys Leu Leu Lys Lys Ser Ala Ser Val Gln Gly Phe Phe 
    290                 295                 300                 


Leu Asn His Tyr Leu Ser Lys Tyr Gln Ala Ala Met Ser His Leu Leu 
305                 310                 315                 320 


Glu Met Cys Val Ser Gly Asp Leu Val Cys Glu Val Asp Leu Gly Asp 
                325                 330                 335     


Leu Ser Pro Glu Gly Arg Phe Thr Gly Leu Glu Ser Ile Phe Arg Ala 
            340                 345                 350         


Val Asn Tyr Met Tyr Met Gly Lys Asn Thr Gly Lys Ile Val Val Glu 
        355                 360                 365             


Leu Pro His Ser Val Asn Ser Lys Leu 
    370                 375         


<210> 5450
<211> 845
<212> PRT
<213> Homo sapiens

<400> 5450
Met Ser Asn Ser Arg Pro Arg Ser Arg Arg Asp Ala Gly Gly Gly Ala 
1               5                   10                  15      


Gly Ala Ala Gly Arg Asp Glu Leu Val Ser Arg Ser Leu Gln Ser Ala 
            20                  25                  30          


Glu His Cys Leu Gly Val Gln Asp Phe Gly Thr Ala Tyr Ala His Tyr 
        35                  40                  45              


Leu Leu Val Leu Ser Leu Ala Pro Glu Leu Lys His Asp Val Lys Glu 
    50                  55                  60                  


Thr Phe Gln Tyr Thr Leu Phe Arg Trp Ala Glu Glu Leu Asp Ala Leu 
65                  70                  75                  80  


Ser Arg Ile Gln Asp Leu Leu Gly Cys Tyr Glu Gln Ala Leu Glu Leu 
                85                  90                  95      


Phe Pro Asp Asp Glu Val Ile Cys Asn Ser Met Gly Glu His Leu Phe 
            100                 105                 110         


Arg Met Gly Phe Arg Asp Glu Ala Ala Gly Tyr Phe His Lys Ala Val 
        115                 120                 125             


Lys Leu Asn Pro Asp Phe Ser Asp Ala Lys Glu Asn Phe Tyr Arg Val 
    130                 135                 140                 


Ala Asn Trp Leu Val Glu Arg Trp His Phe Ile Met Leu Asn Asp Thr 
145                 150                 155                 160 


Lys Arg Asn Thr Ile Tyr Asn Ala Ala Ile Gln Lys Ala Val Cys Leu 
                165                 170                 175     


Gly Ser Lys Ser Val Leu Asp Ile Gly Ala Gly Thr Gly Ile Leu Ser 
            180                 185                 190         


Met Phe Ala Lys Lys Ala Gly Ala His Ser Val Tyr Ala Cys Glu Leu 
        195                 200                 205             


Ser Lys Thr Met Tyr Glu Leu Ala Cys Asp Val Val Ala Ala Asn Lys 
    210                 215                 220                 


Met Glu Ala Gly Ile Lys Leu Leu His Thr Lys Ser Leu Asp Ile Glu 
225                 230                 235                 240 


Ile Pro Lys His Ile Pro Glu Arg Val Ser Leu Val Val Thr Glu Thr 
                245                 250                 255     


Val Asp Ala Gly Leu Phe Gly Glu Gly Ile Val Glu Ser Leu Ile His 
            260                 265                 270         


Ala Trp Glu His Leu Leu Leu Gln Pro Lys Thr Lys Gly Glu Ser Ala 
        275                 280                 285             


Asn Cys Glu Lys Tyr Gly Lys Val Ile Pro Ala Ser Ala Val Ile Phe 
    290                 295                 300                 


Gly Met Ala Val Glu Cys Ala Glu Ile Arg Arg His His Arg Val Gly 
305                 310                 315                 320 


Ile Lys Asp Ile Ala Gly Ile His Leu Pro Thr Asn Val Lys Phe Gln 
                325                 330                 335     


Ser Pro Ala Tyr Ser Ser Val Asp Thr Glu Glu Thr Ile Glu Pro Tyr 
            340                 345                 350         


Thr Thr Glu Lys Met Ser Arg Val Pro Gly Gly Tyr Leu Ala Leu Thr 
        355                 360                 365             


Glu Cys Phe Glu Ile Met Thr Val Asp Phe Asn Asn Leu Gln Glu Leu 
    370                 375                 380                 


Lys Ser Leu Ala Thr Lys Lys Pro Asp Lys Ile Gly Ile Pro Val Ile 
385                 390                 395                 400 


Lys Glu Gly Ile Leu Asp Ala Ile Met Val Trp Phe Val Leu Gln Leu 
                405                 410                 415     


Asp Asp Glu His Ser Leu Ser Thr Ser Pro Ser Glu Glu Thr Cys Trp 
            420                 425                 430         


Glu Gln Ala Val Tyr Pro Val Gln Asp Leu Ala Asp Tyr Trp Ile Lys 
        435                 440                 445             


Pro Gly Asp His Val Met Met Glu Val Ser Cys Gln Asp Cys Tyr Leu 
    450                 455                 460                 


Arg Ile Gln Ser Ile Ser Val Leu Gly Leu Glu Cys Glu Met Asp Val 
465                 470                 475                 480 


Ala Lys Ser Phe Thr Gln Asn Lys Asp Leu Leu Ser Leu Gly Asn Glu 
                485                 490                 495     


Ala Glu Leu Cys Ser Ala Leu Ala Asn Leu Gln Thr Ser Lys Pro Asp 
            500                 505                 510         


Ala Val Glu Gln Thr Cys Ile Leu Glu Ser Thr Glu Ile Ala Leu Leu 
        515                 520                 525             


Asn Asn Ile Pro Tyr His Glu Gly Phe Lys Met Ala Met Ser Lys Val 
    530                 535                 540                 


Leu Ser Ser Leu Thr Pro Glu Lys Leu Tyr Gln Thr Met Asp Thr His 
545                 550                 555                 560 


Cys Gln Asn Glu Met Ser Ser Gly Thr Gly Gln Ser Asn Thr Val Gln 
                565                 570                 575     


Asn Ile Leu Glu Pro Phe Tyr Val Leu Asp Val Ser Glu Gly Phe Ser 
            580                 585                 590         


Val Leu Pro Val Ile Ala Gly Thr Leu Gly Gln Val Lys Pro Tyr Ser 
        595                 600                 605             


Ser Val Glu Lys Asp Gln His Arg Ile Ala Leu Asp Leu Ile Ser Glu 
    610                 615                 620                 


Ala Asn His Phe Pro Lys Glu Thr Leu Glu Phe Trp Leu Arg His Val 
625                 630                 635                 640 


Glu Asp Glu Ser Ala Met Leu Gln Arg Pro Lys Ser Asp Lys Leu Trp 
                645                 650                 655     


Ser Ile Ile Ile Leu Asp Val Ile Glu Pro Ser Gly Leu Ile Gln Gln 
            660                 665                 670         


Glu Ile Met Glu Lys Ala Ala Ile Ser Arg Cys Leu Leu Gln Ser Gly 
        675                 680                 685             


Gly Lys Ile Phe Pro Gln Tyr Val Leu Met Phe Gly Leu Leu Val Glu 
    690                 695                 700                 


Ser Gln Thr Leu Leu Glu Glu Asn Ala Val Gln Gly Thr Glu Arg Thr 
705                 710                 715                 720 


Leu Gly Leu Asn Ile Ala Pro Phe Ile Asn Gln Phe Gln Val Pro Ile 
                725                 730                 735     


Arg Val Phe Leu Asp Leu Ser Ser Leu Pro Cys Ile Pro Leu Ser Lys 
            740                 745                 750         


Pro Val Glu Leu Leu Arg Leu Asp Leu Met Thr Pro Tyr Leu Asn Thr 
        755                 760                 765             


Ser Asn Arg Glu Val Lys Val Tyr Val Cys Lys Ser Gly Arg Leu Thr 
    770                 775                 780                 


Ala Ile Pro Phe Trp Tyr His Met Tyr Leu Asp Glu Glu Ile Arg Leu 
785                 790                 795                 800 


Asp Thr Ser Ser Glu Ala Ser His Trp Lys Gln Ala Ala Val Val Leu 
                805                 810                 815     


Asp Asn Pro Ile Gln Val Glu Met Gly Glu Glu Leu Val Leu Ser Ile 
            820                 825                 830         


Gln His His Lys Ser Asn Val Ser Ile Thr Val Lys Gln 
        835                 840                 845 


<210> 5451
<211> 251
<212> PRT
<213> Homo sapiens

<400> 5451
Met Ala Asp Leu Thr Ser Val Leu Thr Ser Val Met Phe Ser Pro Ser 
1               5                   10                  15      


Ser Lys Met Phe Ile Gly Gly Leu Ser Trp Gln Thr Ser Pro Asp Ser 
            20                  25                  30          


Leu Arg Asp Tyr Phe Ser Lys Phe Gly Glu Ile Arg Glu Cys Met Val 
        35                  40                  45              


Met Arg Asp Pro Thr Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr 
    50                  55                  60                  


Phe Ala Asp Pro Ala Ser Val Asp Lys Val Leu Gly Gln Pro His His 
65                  70                  75                  80  


Glu Leu Asp Ser Lys Thr Ile Asp Pro Lys Val Ala Phe Pro Arg Arg 
                85                  90                  95      


Ala Gln Pro Lys Met Val Thr Arg Thr Lys Lys Ile Phe Val Gly Gly 
            100                 105                 110         


Leu Ser Ala Asn Thr Val Val Glu Asp Val Lys Gln Tyr Phe Glu Gln 
        115                 120                 125             


Phe Gly Lys Val Glu Asp Ala Met Leu Met Phe Asp Lys Thr Thr Asn 
    130                 135                 140                 


Arg His Arg Gly Phe Gly Phe Val Thr Phe Glu Asn Glu Asp Val Val 
145                 150                 155                 160 


Glu Lys Val Cys Glu Ile His Phe His Glu Ile Asn Asn Lys Met Val 
                165                 170                 175     


Glu Cys Lys Lys Ala Gln Pro Lys Glu Val Met Phe Pro Pro Gly Thr 
            180                 185                 190         


Arg Gly Arg Ala Arg Gly Leu Pro Tyr Thr Met Asp Ala Phe Met Leu 
        195                 200                 205             


Gly Met Gly Met Leu Gly Tyr Pro Asn Phe Val Ala Thr Tyr Gly Arg 
    210                 215                 220                 


Gly Tyr Pro Gly Phe Ala Pro Ser Tyr Gly Tyr Gln Phe Pro Asp Tyr 
225                 230                 235                 240 


Leu Pro Val Ser Gln Asp Ile Ile Phe Ile Asn 
                245                 250     


<210> 5452
<211> 169
<212> PRT
<213> Homo sapiens

<400> 5452
Met Ala Pro Lys Arg Ala Lys Arg Arg Thr Val Glu Gly Gly Ser Ser 
1               5                   10                  15      


Ser Val Phe Ser Met Phe Asp Gln Thr Gln Ile Gln Glu Phe Lys Glu 
            20                  25                  30          


Ala Phe Thr Val Ile Asp Gln Asn Arg Asp Gly Ile Ile Asp Lys Glu 
        35                  40                  45              


Asp Leu Arg Asp Thr Phe Ala Ala Met Gly Arg Leu Asn Val Lys Asn 
    50                  55                  60                  


Glu Glu Leu Asp Ala Met Met Lys Glu Ala Ser Gly Pro Ile Asn Phe 
65                  70                  75                  80  


Thr Val Phe Leu Thr Met Phe Gly Glu Lys Leu Lys Gly Ala Asp Pro 
                85                  90                  95      


Glu Asp Val Ile Thr Gly Ala Phe Lys Val Leu Asp Pro Glu Gly Lys 
            100                 105                 110         


Gly Thr Ile Lys Lys Lys Phe Leu Glu Glu Leu Leu Thr Thr Gln Cys 
        115                 120                 125             


Asp Arg Phe Ser Gln Glu Glu Ile Lys Asn Met Trp Ala Ala Phe Pro 
    130                 135                 140                 


Pro Asp Val Gly Gly Asn Val Asp Tyr Lys Asn Ile Cys Tyr Val Ile 
145                 150                 155                 160 


Thr His Gly Asp Ala Lys Asp Gln Glu 
                165                 


<210> 5453
<211> 181
<212> PRT
<213> Homo sapiens

<400> 5453
Met Ala Thr Glu Pro Glu Ala Ala Glu Pro Val Val Pro Ser Leu Val 
1               5                   10                  15      


Asp Arg Tyr Phe Thr Arg Trp Tyr Lys Pro Asp Val Lys Gly Lys Phe 
            20                  25                  30          


Cys Glu Asp His Cys Ile Leu Gln His Ser Asn Arg Ile Cys Val Ile 
        35                  40                  45              


Thr Leu Ala Glu Ser His Pro Val Leu Gln Ser Gly Lys Thr Ile Lys 
    50                  55                  60                  


Ser Ile Ser Tyr Gln Ile Ser Thr Asn Cys Ser Arg Leu Gln Asn Lys 
65                  70                  75                  80  


Val Ser Gly Lys Phe Lys Arg Gly Ala Gln Phe Leu Thr Glu Leu Ala 
                85                  90                  95      


Pro Leu Cys Lys Ile Tyr Cys Ser Asp Gly Glu Glu Tyr Thr Val Ser 
            100                 105                 110         


Ser Cys Val Arg Gly Arg Leu Met Glu Val Asn Glu Asn Ile Leu His 
        115                 120                 125             


Lys Pro Ser Ile Leu Gln Glu Lys Pro Ser Thr Glu Gly Tyr Ile Ala 
    130                 135                 140                 


Val Val Leu Pro Lys Phe Glu Glu Ser Lys Ser Ile Thr Glu Gly Leu 
145                 150                 155                 160 


Leu Thr Gln Lys Gln Tyr Glu Glu Val Met Val Lys Arg Ile Asn Ala 
                165                 170                 175     


Thr Thr Ala Thr Ser 
            180     


<210> 5454
<211> 717
<212> PRT
<213> Homo sapiens

<400> 5454
Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser 
1               5                   10                  15      


Gly Asn Leu Ala His Val Glu Lys Val Glu Ser Leu Ser Ser Asp Gly 
            20                  25                  30          


Glu Gly Val Gly Gly Gly Ala Ser Ala Leu Thr Ser Gly Ile Ala Ser 
        35                  40                  45              


Ser Pro Asp Tyr Glu Phe Asn Val Trp Thr Arg Pro Asp Cys Ala Glu 
    50                  55                  60                  


Thr Glu Phe Glu Asn Gly Asn Arg Ser Trp Phe Tyr Phe Ser Val Arg 
65                  70                  75                  80  


Gly Gly Met Pro Gly Lys Leu Ile Lys Ile Asn Ile Met Asn Met Asn 
                85                  90                  95      


Lys Gln Ser Lys Leu Tyr Ser Gln Gly Met Ala Pro Phe Val Arg Thr 
            100                 105                 110         


Leu Pro Thr Arg Pro Arg Trp Glu Arg Ile Arg Asp Arg Pro Thr Phe 
        115                 120                 125             


Glu Met Thr Glu Thr Gln Phe Val Leu Ser Phe Val His Arg Phe Val 
    130                 135                 140                 


Glu Gly Arg Gly Ala Thr Thr Phe Phe Ala Phe Cys Tyr Pro Phe Ser 
145                 150                 155                 160 


Tyr Ser Asp Cys Gln Glu Leu Leu Asn Gln Leu Asp Gln Arg Phe Pro 
                165                 170                 175     


Glu Asn His Pro Thr His Ser Ser Pro Leu Asp Thr Ile Tyr Tyr His 
            180                 185                 190         


Arg Glu Leu Leu Cys Tyr Ser Leu Asp Gly Leu Arg Val Asp Leu Leu 
        195                 200                 205             


Thr Ile Thr Ser Cys His Gly Leu Arg Glu Asp Arg Glu Pro Arg Leu 
    210                 215                 220                 


Glu Gln Leu Phe Pro Asp Thr Ser Thr Pro Arg Pro Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Lys Arg Ile Phe Phe Leu Ser Ser Arg Val His Pro Gly Glu Thr 
                245                 250                 255     


Pro Ser Ser Phe Val Phe Asn Gly Phe Leu Asp Phe Ile Leu Arg Pro 
            260                 265                 270         


Asp Asp Pro Arg Ala Gln Thr Leu Arg Arg Leu Phe Val Phe Lys Leu 
        275                 280                 285             


Ile Pro Met Leu Asn Pro Asp Gly Val Val Arg Gly His Tyr Arg Thr 
    290                 295                 300                 


Asp Ser Arg Gly Val Asn Leu Asn Arg Gln Tyr Leu Lys Pro Asp Ala 
305                 310                 315                 320 


Val Leu His Pro Ala Ile Tyr Gly Ala Lys Ala Val Leu Leu Tyr His 
                325                 330                 335     


His Val His Ser Arg Leu Asn Ser Gln Ser Ser Ser Glu His Gln Pro 
            340                 345                 350         


Ser Ser Cys Leu Pro Pro Asp Ala Pro Val Ser Asp Leu Glu Lys Ala 
        355                 360                 365             


Asn Asn Leu Gln Asn Glu Ala Gln Cys Gly His Ser Ala Asp Arg His 
    370                 375                 380                 


Asn Ala Glu Ala Trp Lys Gln Thr Glu Pro Ala Glu Gln Lys Leu Asn 
385                 390                 395                 400 


Ser Val Trp Ile Met Pro Gln Gln Ser Ala Gly Leu Glu Glu Ser Ala 
                405                 410                 415     


Pro Asp Thr Ile Pro Pro Lys Glu Ser Gly Val Ala Tyr Tyr Val Asp 
            420                 425                 430         


Leu His Gly His Ala Ser Lys Arg Gly Cys Phe Met Tyr Gly Asn Ser 
        435                 440                 445             


Phe Ser Asp Glu Ser Thr Gln Val Glu Asn Met Leu Tyr Pro Lys Leu 
    450                 455                 460                 


Ile Ser Leu Asn Ser Ala His Phe Asp Phe Gln Gly Cys Asn Phe Ser 
465                 470                 475                 480 


Glu Lys Asn Met Tyr Ala Arg Asp Arg Arg Asp Gly Gln Ser Lys Glu 
                485                 490                 495     


Gly Ser Gly Arg Val Ala Ile Tyr Lys Ala Ser Gly Ile Ile His Ser 
            500                 505                 510         


Tyr Thr Leu Glu Cys Asn Tyr Asn Thr Gly Arg Ser Val Asn Ser Ile 
        515                 520                 525             


Pro Ala Ala Cys His Asp Asn Gly Arg Ala Ser Pro Pro Pro Pro Pro 
    530                 535                 540                 


Ala Phe Pro Ser Arg Tyr Thr Val Glu Leu Phe Glu Gln Val Gly Arg 
545                 550                 555                 560 


Ala Met Ala Ile Ala Ala Leu Asp Met Ala Glu Cys Asn Pro Trp Pro 
                565                 570                 575     


Arg Ile Val Leu Ser Glu His Ser Ser Leu Thr Asn Leu Arg Ala Trp 
            580                 585                 590         


Met Leu Lys His Val Arg Asn Ser Arg Gly Leu Ser Ser Thr Leu Asn 
        595                 600                 605             


Val Gly Val Asn Lys Lys Arg Gly Leu Arg Thr Pro Pro Lys Ser His 
    610                 615                 620                 


Asn Gly Leu Pro Val Ser Cys Ser Glu Asn Thr Leu Ser Arg Ala Arg 
625                 630                 635                 640 


Ser Phe Ser Thr Gly Thr Ser Ala Gly Gly Ser Ser Ser Ser Gln Gln 
                645                 650                 655     


Asn Ser Pro Gln Met Lys Asn Ser Pro Ser Phe Pro Phe His Gly Ser 
            660                 665                 670         


Arg Pro Ala Gly Leu Pro Gly Leu Gly Ser Ser Thr Gln Lys Val Thr 
        675                 680                 685             


His Arg Val Leu Gly Pro Val Arg Gly Lys Pro Val Trp Glu Pro Leu 
    690                 695                 700                 


Gln His Val Phe Gly Cys Leu Gly His Cys Trp Gly Lys 
705                 710                 715         


<210> 5455
<211> 225
<212> PRT
<213> Homo sapiens

<400> 5455
Met Val Met Ala Glu Gly Thr Ala Val Leu Arg Arg Asn Arg Pro Gly 
1               5                   10                  15      


Thr Lys Ala Gln Asp Phe Tyr Asn Trp Pro Asp Glu Ser Phe Asp Glu 
            20                  25                  30          


Met Asp Ser Thr Leu Ala Val Gln Gln Tyr Ile Gln Gln Asn Ile Arg 
        35                  40                  45              


Ala Asp Cys Ser Asn Ile Asp Lys Ile Leu Glu Pro Pro Glu Gly Gln 
    50                  55                  60                  


Asp Glu Gly Val Trp Lys Tyr Glu His Leu Arg Gln Phe Cys Leu Glu 
65                  70                  75                  80  


Leu Asn Gly Leu Ala Val Lys Leu Gln Ser Glu Cys His Pro Asp Thr 
                85                  90                  95      


Cys Thr Gln Met Thr Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala 
            100                 105                 110         


His Lys Thr Pro Lys Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr 
        115                 120                 125             


Leu Asp Gly Ala Ala Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser 
    130                 135                 140                 


Arg Val Ser Ile Lys Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys 
145                 150                 155                 160 


Arg Arg Ile Tyr Arg Ile Phe Ser His Ala Tyr Phe His His Arg Gln 
                165                 170                 175     


Ile Phe Asp Glu Tyr Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr 
            180                 185                 190         


Lys Phe Val Met Lys Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val 
        195                 200                 205             


Pro Ile Leu Glu Glu Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu 
    210                 215                 220                 


Ala 
225 


<210> 5456
<211> 390
<212> PRT
<213> Homo sapiens

<400> 5456
Met Ala Ala Gln Lys Asp Leu Trp Asp Ala Ile Val Ile Gly Ala Gly 
1               5                   10                  15      


Ile Gln Gly Cys Phe Thr Ala Tyr His Leu Ala Lys His Arg Lys Arg 
            20                  25                  30          


Ile Leu Leu Leu Glu Gln Phe Phe Leu Pro His Ser Arg Gly Ser Ser 
        35                  40                  45              


His Gly Gln Ser Arg Ile Ile Arg Lys Ala Tyr Leu Glu Asp Phe Tyr 
    50                  55                  60                  


Thr Arg Met Met His Glu Cys Tyr Gln Ile Trp Ala Gln Leu Glu His 
65                  70                  75                  80  


Glu Ala Gly Thr Gln Leu His Arg Gln Thr Gly Leu Leu Leu Leu Gly 
                85                  90                  95      


Met Lys Glu Asn Gln Glu Leu Lys Thr Ile Gln Ala Asn Leu Ser Arg 
            100                 105                 110         


Gln Arg Val Glu His Gln Cys Leu Ser Ser Glu Glu Leu Lys Gln Arg 
        115                 120                 125             


Phe Pro Asn Ile Arg Leu Pro Arg Gly Glu Val Gly Leu Leu Asp Asn 
    130                 135                 140                 


Ser Gly Gly Val Ile Tyr Ala Tyr Lys Ala Leu Arg Ala Leu Gln Asp 
145                 150                 155                 160 


Ala Ile Arg Gln Leu Gly Gly Ile Val Arg Asp Gly Glu Lys Val Val 
                165                 170                 175     


Glu Ile Asn Pro Gly Leu Leu Val Thr Val Lys Thr Thr Ser Arg Ser 
            180                 185                 190         


Tyr Gln Ala Lys Ser Leu Val Ile Thr Ala Gly Pro Trp Thr Asn Gln 
        195                 200                 205             


Leu Leu Arg Pro Leu Gly Ile Glu Met Pro Leu Gln Thr Leu Arg Ile 
    210                 215                 220                 


Asn Val Cys Tyr Trp Arg Glu Met Val Pro Gly Ser Tyr Gly Val Ser 
225                 230                 235                 240 


Gln Ala Phe Pro Cys Phe Leu Trp Leu Gly Leu Cys Pro His His Ile 
                245                 250                 255     


Tyr Gly Leu Pro Thr Gly Glu Tyr Pro Gly Leu Met Lys Val Ser Tyr 
            260                 265                 270         


His His Gly Asn His Ala Asp Pro Glu Glu Arg Asp Cys Pro Thr Ala 
        275                 280                 285             


Arg Thr Asp Ile Gly Asp Val Gln Ile Leu Ser Ser Phe Val Arg Asp 
    290                 295                 300                 


His Leu Pro Asp Leu Lys Pro Glu Pro Ala Val Ile Glu Ser Cys Met 
305                 310                 315                 320 


Tyr Thr Asn Thr Pro Asp Glu Gln Phe Ile Leu Asp Arg His Pro Lys 
                325                 330                 335     


Tyr Asp Asn Ile Val Ile Gly Ala Gly Phe Ser Gly His Gly Phe Lys 
            340                 345                 350         


Leu Ala Pro Val Val Gly Lys Ile Leu Tyr Glu Leu Ser Met Lys Leu 
        355                 360                 365             


Thr Pro Ser Tyr Asp Leu Ala Pro Phe Arg Ile Ser Arg Phe Pro Ser 
    370                 375                 380                 


Leu Gly Lys Ala His Leu 
385                 390 


<210> 5457
<211> 44
<212> PRT
<213> Homo sapiens

<400> 5457
Met Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Met Gln Glu Lys Asn Pro Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Gln Ala Ser Glu Ser 
        35                  40                  


<210> 5458
<211> 440
<212> PRT
<213> Homo sapiens

<400> 5458
Met Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Thr Phe His Gln Ala Asn Thr Glu Gln Pro Lys Leu Ser Arg Asp 
            20                  25                  30          


Glu Gln Arg Gly Arg Gly Ala Leu Leu Gln Asp Ile Cys Lys Gly Thr 
        35                  40                  45              


Lys Leu Lys Lys Val Thr Asn Ile Asn Asp Arg Ser Ala Pro Ile Leu 
    50                  55                  60                  


Glu Lys Pro Lys Gly Ser Ser Gly Gly Tyr Gly Ser Gly Gly Ala Ala 
65                  70                  75                  80  


Leu Gln Pro Lys Gly Gly Leu Phe Gln Gly Gly Val Leu Lys Leu Arg 
                85                  90                  95      


Pro Val Gly Ala Lys Asp Gly Ser Glu Asn Leu Ala Gly Lys Pro Ala 
            100                 105                 110         


Leu Gln Ile Pro Ser Ser Arg Ala Ala Ala Pro Arg Pro Pro Val Ser 
        115                 120                 125             


Ala Ala Ser Gly Arg Pro Gln Asp Asp Thr Asp Ser Ser Arg Ala Ser 
    130                 135                 140                 


Leu Pro Glu Leu Pro Arg Met Gln Arg Pro Ser Leu Pro Asp Leu Ser 
145                 150                 155                 160 


Arg Pro Asn Thr Thr Ser Ser Thr Gly Met Lys His Ser Ser Ser Ala 
                165                 170                 175     


Pro Pro Pro Pro Pro Pro Gly Arg Arg Ala Asn Ala Pro Pro Thr Pro 
            180                 185                 190         


Leu Pro Met His Ser Ser Lys Ala Pro Ala Tyr Asn Arg Glu Lys Pro 
        195                 200                 205             


Leu Pro Pro Thr Pro Gly Gln Arg Leu His Pro Gly Arg Glu Gly Pro 
    210                 215                 220                 


Pro Ala Pro Pro Pro Val Lys Pro Pro Pro Ser Pro Val Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Pro Ser Gly Gln Ser Leu Ala Pro Pro Pro Pro Pro Tyr Arg 
                245                 250                 255     


Gln Pro Pro Gly Val Pro Asn Gly Pro Ser Ser Pro Thr Asn Glu Ser 
            260                 265                 270         


Ala Pro Glu Leu Pro Gln Arg His Asn Ser Leu His Arg Lys Thr Pro 
        275                 280                 285             


Gly Pro Val Arg Gly Leu Ala Pro Pro Pro Pro Thr Ser Ala Ser Pro 
    290                 295                 300                 


Ser Leu Leu Ser Asn Arg Pro Pro Pro Pro Ala Arg Asp Pro Pro Ser 
305                 310                 315                 320 


Arg Gly Ala Ala Pro Pro Pro Pro Pro Pro Val Ile Arg Asn Gly Ala 
                325                 330                 335     


Arg Asp Ala Pro Pro Pro Pro Pro Pro Tyr Arg Met His Gly Ser Glu 
            340                 345                 350         


Pro Pro Ser Arg Gly Lys Pro Pro Pro Pro Pro Ser Arg Thr Pro Ala 
        355                 360                 365             


Gly Pro Pro Pro Pro Pro Pro Pro Pro Leu Arg Asn Gly His Arg Asp 
    370                 375                 380                 


Ser Ile Thr Thr Val Arg Ser Phe Leu Asp Asp Phe Glu Ser Lys Tyr 
385                 390                 395                 400 


Ser Phe His Pro Val Glu Asp Phe Pro Ala Pro Glu Glu Tyr Lys His 
                405                 410                 415     


Phe Gln Arg Ile Tyr Pro Ser Lys Thr Asn Arg Ala Ala Arg Gly Ala 
            420                 425                 430         


Pro Pro Leu Pro Pro Ile Leu Arg 
        435                 440 


<210> 5459
<211> 900
<212> PRT
<213> Homo sapiens

<400> 5459
Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly 
1               5                   10                  15      


Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro 
            20                  25                  30          


Ala Phe Gly Gly Gly Val Cys Cys Phe Glu His Leu Pro Gly Gly Asp 
        35                  40                  45              


Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly 
    50                  55                  60                  


Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu 
65                  70                  75                  80  


Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser 
                85                  90                  95      


Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val Pro Thr 
        115                 120                 125             


Asn Ser Gly Gly Gly Gly Ala Thr Gly Gly Ser Pro Gly Glu Arg Lys 
    130                 135                 140                 


Arg Thr Arg Leu Gly Gly Pro Ala Ala Arg His Arg Tyr Glu Val Val 
145                 150                 155                 160 


Thr Glu Leu Gly Pro Glu Glu Val Arg Trp Phe Tyr Lys Glu Asp Lys 
                165                 170                 175     


Lys Thr Trp Lys Pro Phe Ile Gly Tyr Asp Ser Leu Arg Ile Glu Leu 
            180                 185                 190         


Ala Phe Arg Thr Leu Leu Gln Thr Thr Gly Ala Arg Pro Gln Gly Gly 
        195                 200                 205             


Asp Arg Asp Gly Asp His Val Cys Ser Pro Thr Gly Pro Ala Ser Ser 
    210                 215                 220                 


Ser Gly Glu Asp Asp Asp Glu Asp Arg Ala Cys Gly Phe Cys Gln Ser 
225                 230                 235                 240 


Thr Thr Gly His Glu Pro Glu Met Val Glu Leu Val Asn Ile Glu Pro 
                245                 250                 255     


Val Cys Val Arg Gly Gly Leu Tyr Glu Val Asp Val Thr Gln Gly Glu 
            260                 265                 270         


Cys Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val Met Arg 
        275                 280                 285             


Gly Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu Glu Glu 
    290                 295                 300                 


Ser Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly Gln Gln 
305                 310                 315                 320 


Met Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp Gly Lys 
                325                 330                 335     


Asp Ala Val His Ser Phe Lys Leu Ser Arg Asn His Val Asp Trp His 
            340                 345                 350         


Ser Val Asp Glu Val Tyr Leu Tyr Ser Asp Ala Thr Thr Ser Lys Ile 
        355                 360                 365             


Ala Arg Thr Val Thr Gln Lys Leu Gly Phe Ser Lys Ala Ser Ser Ser 
    370                 375                 380                 


Gly Thr Arg Leu His Arg Gly Tyr Val Glu Glu Ala Thr Leu Glu Asp 
385                 390                 395                 400 


Lys Pro Ser Gln Thr Thr His Ile Val Phe Val Val His Gly Ile Gly 
                405                 410                 415     


Gln Lys Met Asp Gln Gly Arg Ile Ile Lys Asn Thr Ala Met Met Arg 
            420                 425                 430         


Glu Ala Ala Arg Lys Ile Glu Glu Arg His Phe Ser Asn His Ala Thr 
        435                 440                 445             


His Val Glu Phe Leu Pro Val Glu Trp Arg Ser Lys Leu Thr Leu Asp 
    450                 455                 460                 


Gly Asp Thr Val Asp Ser Ile Thr Pro Asp Lys Val Arg Gly Leu Arg 
465                 470                 475                 480 


Asp Met Leu Asn Ser Ser Ala Met Asp Ile Met Tyr Tyr Thr Ser Pro 
                485                 490                 495     


Leu Tyr Arg Asp Glu Leu Val Lys Gly Leu Gln Gln Glu Leu Asn Arg 
            500                 505                 510         


Leu Tyr Ser Leu Phe Cys Ser Arg Asn Pro Asp Phe Glu Glu Lys Gly 
        515                 520                 525             


Gly Lys Val Ser Ile Val Ser His Ser Leu Gly Cys Val Ile Thr Tyr 
    530                 535                 540                 


Asp Ile Met Thr Gly Trp Asn Pro Val Arg Leu Tyr Glu Gln Leu Leu 
545                 550                 555                 560 


Gln Lys Glu Glu Glu Leu Pro Asp Glu Arg Trp Met Ser Tyr Glu Glu 
                565                 570                 575     


Arg His Leu Leu Asp Glu Leu Tyr Ile Thr Lys Arg Arg Leu Lys Glu 
            580                 585                 590         


Ile Glu Glu Arg Leu His Gly Leu Lys Ala Ser Ser Met Thr Gln Thr 
        595                 600                 605             


Pro Ala Leu Lys Phe Lys Val Glu Asn Phe Phe Cys Met Gly Ser Pro 
    610                 615                 620                 


Leu Ala Val Phe Leu Ala Leu Arg Gly Ile Arg Pro Gly Asn Thr Gly 
625                 630                 635                 640 


Ser Gln Asp His Ile Leu Pro Arg Glu Ile Cys Asn Arg Leu Leu Asn 
                645                 650                 655     


Ile Phe His Pro Thr Asp Pro Val Ala Tyr Arg Leu Glu Pro Leu Ile 
            660                 665                 670         


Leu Lys His Tyr Ser Asn Ile Ser Pro Val Gln Ile His Trp Tyr Asn 
        675                 680                 685             


Thr Ser Asn Pro Leu Pro Tyr Glu His Met Lys Pro Ser Phe Leu Asn 
    690                 695                 700                 


Pro Ala Lys Glu Pro Thr Ser Val Ser Glu Asn Glu Gly Ile Ser Thr 
705                 710                 715                 720 


Ile Pro Ser Pro Val Thr Ser Pro Val Leu Ser Arg Arg His Tyr Gly 
                725                 730                 735     


Glu Ser Ile Thr Asn Ile Gly Lys Ala Ser Ile Leu Gly Ala Ala Ser 
            740                 745                 750         


Ile Gly Lys Gly Leu Gly Gly Met Leu Phe Ser Arg Phe Gly Arg Ser 
        755                 760                 765             


Ser Thr Thr Gln Ser Ser Glu Thr Ser Lys Asp Ser Met Glu Asp Glu 
    770                 775                 780                 


Lys Lys Pro Val Ala Ser Pro Ser Ala Thr Thr Val Gly Thr Gln Thr 
785                 790                 795                 800 


Leu Pro His Ser Ser Ser Gly Phe Leu Asp Ser Ala Tyr Phe Arg Leu 
                805                 810                 815     


Gln Glu Ser Phe Phe Asn Leu Pro Gln Leu Leu Phe Pro Glu Asn Val 
            820                 825                 830         


Met Gln Asn Lys Asp Asn Ala Leu Val Glu Leu Asp His Arg Ile Asp 
        835                 840                 845             


Phe Glu Leu Arg Glu Gly Leu Val Glu Ser Arg Tyr Trp Ser Ala Val 
    850                 855                 860                 


Thr Ser His Thr Ala Tyr Trp Ser Ser Leu Asp Val Ala Leu Phe Leu 
865                 870                 875                 880 


Leu Thr Phe Met Tyr Lys His Glu His Asp Asp Asp Ala Lys Pro Asn 
                885                 890                 895     


Leu Asp Pro Ile 
            900 


<210> 5460
<211> 425
<212> PRT
<213> Homo sapiens

<400> 5460
Met Asn Lys Met Pro Ala Gly Glu Gln Glu Cys Glu Tyr Asn Lys Glu 
1               5                   10                  15      


Gly Lys Tyr Tyr Ser Lys Gly Val Lys Leu Val Arg Lys Lys Lys Lys 
            20                  25                  30          


Ile Pro Gly Tyr Arg Trp Gly Asp Ile Lys Ile Asn Ile Ile Gly Glu 
        35                  40                  45              


Lys Asp Asp Leu Pro Ile His Phe Cys Asp Lys Cys Asp Leu Pro Ile 
    50                  55                  60                  


Lys Ile Tyr Gly Arg Ile Ile Pro Cys Lys His Ala Phe Cys Tyr His 
65                  70                  75                  80  


Cys Ala Asn Leu Tyr Asp Lys Val Gly Tyr Lys Val Cys Pro Arg Cys 
                85                  90                  95      


Arg Tyr Pro Val Leu Arg Ile Glu Ala His Lys Arg Gly Ser Val Phe 
            100                 105                 110         


Met Cys Ser Ile Val Gln Gln Cys Lys Arg Thr Tyr Leu Ser Gln Lys 
        115                 120                 125             


Ser Leu Gln Ala His Ile Lys Arg Arg His Lys Arg Ala Arg Lys Gln 
    130                 135                 140                 


Val Thr Ser Ala Ser Leu Glu Lys Val Arg Pro His Ile Ala Pro Pro 
145                 150                 155                 160 


Gln Thr Glu Ile Ser Asp Ile Pro Lys Arg Leu Gln Asp Arg Asp His 
                165                 170                 175     


Leu Ser Tyr Ile Pro Pro Glu Gln His Thr Met Val Ser Leu Pro Ser 
            180                 185                 190         


Val Gln His Met Leu Gln Glu Gln His Asn Gln Pro His Lys Asp Ile 
        195                 200                 205             


Gln Ala Pro Pro Pro Glu Leu Ser Leu Ser Leu Pro Phe Pro Ile Gln 
    210                 215                 220                 


Trp Glu Thr Val Ser Ile Phe Thr Arg Lys His Gly Asn Leu Thr Val 
225                 230                 235                 240 


Asp His Ile Gln Asn Asn Ser Asp Ser Gly Ala Lys Lys Pro Thr Pro 
                245                 250                 255     


Pro Asp Tyr Tyr Pro Glu Cys Gln Ser Gln Pro Ala Val Ser Ser Pro 
            260                 265                 270         


His His Ile Ile Pro Gln Lys Gln His Tyr Ala Pro Pro Pro Ser Pro 
        275                 280                 285             


Ser Ser Pro Val Asn His Gln Met Pro Tyr Pro Pro Gln Asp Val Val 
    290                 295                 300                 


Thr Pro Asn Ser Val Arg Ser Gln Val Pro Ala Leu Thr Thr Thr Tyr 
305                 310                 315                 320 


Asp Pro Ser Ser Gly Tyr Ile Ile Val Lys Val Pro Pro Asp Met Asn 
                325                 330                 335     


Ser Pro Pro Leu Arg Ala Pro Gln Ser Gln Asn Gly Asn Pro Ser Ala 
            340                 345                 350         


Ser Glu Phe Ala Ser His His Tyr Asn Leu Asn Ile Leu Pro Gln Phe 
        355                 360                 365             


Thr Glu Asn Gln Glu Thr Leu Ser Pro Gln Phe Thr Gln Thr Asp Ala 
    370                 375                 380                 


Met Asp His Arg Arg Trp Pro Ala Trp Lys Arg Leu Ser Pro Cys Pro 
385                 390                 395                 400 


Pro Thr Arg Ser Pro Pro Pro Ser Thr Leu His Gly Arg Ser His His 
                405                 410                 415     


Ser His Gln Arg Arg His Arg Arg Tyr 
            420                 425 


<210> 5461
<211> 641
<212> PRT
<213> Homo sapiens

<400> 5461
Met Gly Pro Pro Leu Lys Leu Phe Lys Asn Gln Lys Tyr Gln Glu Leu 
1               5                   10                  15      


Lys Gln Glu Cys Ile Lys Asp Ser Arg Leu Phe Cys Asp Pro Thr Phe 
            20                  25                  30          


Leu Pro Glu Asn Asp Ser Leu Phe Tyr Asn Arg Leu Leu Pro Gly Lys 
        35                  40                  45              


Val Val Trp Lys Arg Pro Gln Asp Ile Cys Asp Asp Pro His Leu Ile 
    50                  55                  60                  


Val Gly Asn Ile Ser Asn His Gln Leu Thr Gln Gly Arg Leu Gly His 
65                  70                  75                  80  


Lys Pro Met Val Ser Ala Phe Ser Cys Leu Ala Val Gln Glu Ser His 
                85                  90                  95      


Trp Thr Lys Thr Ile Pro Asn His Lys Glu Gln Glu Trp Asp Pro Gln 
            100                 105                 110         


Lys Thr Glu Lys Tyr Ala Gly Ile Phe His Phe Arg Phe Trp His Phe 
        115                 120                 125             


Gly Glu Trp Thr Glu Val Val Ile Asp Asp Leu Leu Pro Thr Ile Asn 
    130                 135                 140                 


Gly Asp Leu Val Phe Ser Phe Ser Thr Ser Met Asn Glu Phe Trp Asn 
145                 150                 155                 160 


Ala Leu Leu Glu Lys Ala Tyr Ala Lys Leu Leu Gly Cys Tyr Glu Ala 
                165                 170                 175     


Leu Asp Gly Leu Thr Ile Thr Asp Ile Ile Val Asp Phe Thr Gly Thr 
            180                 185                 190         


Leu Ala Glu Thr Val Asp Met Gln Lys Gly Arg Tyr Thr Glu Leu Val 
        195                 200                 205             


Glu Glu Lys Tyr Lys Leu Phe Gly Glu Leu Tyr Lys Thr Phe Thr Lys 
    210                 215                 220                 


Gly Gly Leu Ile Cys Cys Ser Ile Glu Ser Pro Asn Gln Glu Glu Gln 
225                 230                 235                 240 


Glu Val Glu Thr Asp Trp Gly Leu Leu Lys Gly His Thr Tyr Thr Met 
                245                 250                 255     


Thr Asp Ile Arg Lys Ile Arg Leu Gly Glu Arg Leu Val Glu Val Phe 
            260                 265                 270         


Ser Ala Glu Lys Val Tyr Met Val Arg Leu Arg Asn Pro Leu Gly Arg 
        275                 280                 285             


Gln Glu Trp Ser Gly Pro Trp Ser Glu Ile Ser Glu Glu Trp Gln Gln 
    290                 295                 300                 


Leu Thr Ala Ser Asp Arg Lys Asn Leu Gly Leu Val Met Ser Asp Asp 
305                 310                 315                 320 


Gly Glu Phe Trp Met Ser Leu Glu Asp Phe Cys Arg Asn Phe His Lys 
                325                 330                 335     


Leu Asn Val Cys Arg Asn Val Asn Asn Pro Ile Phe Gly Arg Lys Glu 
            340                 345                 350         


Leu Glu Ser Val Leu Gly Cys Trp Thr Val Asp Asp Asp Pro Leu Met 
        355                 360                 365             


Asn Arg Ser Gly Gly Cys Tyr Asn Asn Arg Asp Thr Phe Leu Gln Asn 
    370                 375                 380                 


Pro Gln Tyr Ile Phe Thr Val Pro Glu Asp Gly His Lys Val Ile Met 
385                 390                 395                 400 


Ser Leu Gln Gln Lys Asp Leu Arg Thr Tyr Arg Arg Met Gly Arg Pro 
                405                 410                 415     


Asp Asn Tyr Ile Ile Gly Phe Glu Leu Phe Lys Val Glu Met Asn Arg 
            420                 425                 430         


Lys Phe Arg Leu His His Leu Tyr Ile Gln Glu Arg Ala Gly Thr Ser 
        435                 440                 445             


Thr Tyr Ile Asp Thr Arg Thr Val Phe Leu Ser Lys Tyr Leu Lys Lys 
    450                 455                 460                 


Gly Asn Tyr Val Leu Val Pro Thr Met Phe Gln His Gly Arg Thr Ser 
465                 470                 475                 480 


Glu Phe Leu Leu Arg Ile Phe Ser Glu Val Pro Val Gln Leu Arg Glu 
                485                 490                 495     


Leu Thr Leu Asp Met Pro Lys Met Ser Cys Trp Asn Leu Ala Arg Gly 
            500                 505                 510         


Tyr Pro Lys Val Val Thr Gln Ile Thr Val His Ser Ala Glu Asp Leu 
        515                 520                 525             


Glu Lys Lys Tyr Ala Asn Glu Thr Val Asn Pro Tyr Leu Val Ile Lys 
    530                 535                 540                 


Cys Gly Lys Glu Glu Val Arg Ser Pro Val Gln Lys Asn Thr Val His 
545                 550                 555                 560 


Ala Ile Phe Asp Thr Gln Ala Ile Phe Tyr Arg Arg Thr Thr Asp Ile 
                565                 570                 575     


Pro Ile Ile Val Gln Val Trp Asn Ser Arg Lys Phe Cys Asp Gln Phe 
            580                 585                 590         


Leu Gly Gln Val Thr Leu Asp Ala Asp Pro Ser Asp Cys Arg Asp Leu 
        595                 600                 605             


Lys Ser Leu Tyr Leu Arg Lys Lys Gly Gly Pro Thr Ala Lys Val Lys 
    610                 615                 620                 


Gln Gly His Ile Ser Phe Lys Val Ile Ser Ser Asp Asp Leu Thr Glu 
625                 630                 635                 640 


Leu 
    


<210> 5462
<211> 1059
<212> PRT
<213> Homo sapiens

<400> 5462
Met Ala Ala Val Ala Gly Ser Gly Ala Ala Ala Ala Pro Ser Ser Leu 
1               5                   10                  15      


Leu Leu Val Val Gly Ser Glu Phe Gly Ser Pro Gly Leu Leu Thr Tyr 
            20                  25                  30          


Val Leu Glu Glu Leu Glu Arg Gly Ile Arg Ser Trp Asp Val Asp Pro 
        35                  40                  45              


Gly Val Cys Asn Leu Asp Glu Gln Leu Lys Val Phe Val Ser Arg His 
    50                  55                  60                  


Ser Ala Thr Phe Ser Ser Ile Val Lys Gly Gln Arg Ser Leu His His 
65                  70                  75                  80  


Arg Gly Asp Asn Leu Glu Thr Leu Val Leu Leu Asn Pro Ser Asp Lys 
                85                  90                  95      


Ser Leu Tyr Asp Glu Leu Arg Asn Leu Leu Leu Asp Pro Ala Ser His 
            100                 105                 110         


Lys Leu Leu Val Leu Ala Gly Pro Cys Leu Glu Glu Thr Gly Glu Leu 
        115                 120                 125             


Leu Leu Gln Thr Gly Gly Phe Ser Pro His His Phe Leu Gln Val Leu 
    130                 135                 140                 


Lys Asp Arg Glu Ile Arg Asp Ile Leu Ala Thr Thr Pro Pro Pro Val 
145                 150                 155                 160 


Gln Pro Pro Ile Leu Thr Ile Thr Cys Pro Thr Phe Gly Asp Trp Ala 
                165                 170                 175     


Gln Leu Ala Pro Ala Val Pro Gly Leu Gln Gly Ala Leu Arg Leu Gln 
            180                 185                 190         


Leu Arg Leu Asn Pro Pro Ala Gln Leu Pro Asn Ser Glu Gly Leu Cys 
        195                 200                 205             


Glu Phe Leu Glu Tyr Val Ala Glu Ser Leu Glu Pro Pro Ser Pro Phe 
    210                 215                 220                 


Glu Leu Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Arg Leu Gly Arg 
225                 230                 235                 240 


Pro Cys Cys Tyr Ile Phe Pro Gly Gly Leu Gly Asp Ala Ala Phe Phe 
                245                 250                 255     


Ala Val Asn Gly Phe Thr Val Leu Val Asn Gly Gly Ser Asn Pro Lys 
            260                 265                 270         


Ser Ser Phe Trp Lys Leu Val Arg His Leu Asp Arg Val Asp Ala Val 
        275                 280                 285             


Leu Val Thr His Pro Gly Ala Asp Ser Leu Pro Gly Leu Asn Ser Leu 
    290                 295                 300                 


Leu Arg Arg Lys Leu Ala Glu Arg Ser Glu Val Ala Ala Gly Gly Gly 
305                 310                 315                 320 


Ser Trp Asp Asp Arg Leu Arg Arg Leu Ile Ser Pro Asn Leu Gly Val 
                325                 330                 335     


Val Phe Phe Asn Ala Cys Glu Ala Ala Ser Arg Leu Ala Arg Gly Glu 
            340                 345                 350         


Asp Glu Ala Glu Leu Ala Leu Ser Leu Leu Ala Gln Leu Gly Ile Thr 
        355                 360                 365             


Pro Leu Pro Leu Ser Arg Gly Pro Val Pro Ala Lys Pro Thr Val Leu 
    370                 375                 380                 


Phe Glu Lys Met Gly Val Gly Arg Leu Asp Met Tyr Val Leu His Pro 
385                 390                 395                 400 


Pro Ser Ala Gly Ala Glu Arg Thr Leu Ala Ser Val Cys Ala Leu Leu 
                405                 410                 415     


Val Trp His Pro Ala Gly Pro Gly Glu Lys Val Val Arg Val Leu Phe 
            420                 425                 430         


Pro Gly Cys Thr Pro Pro Ala Cys Leu Leu Asp Gly Leu Val Arg Leu 
        435                 440                 445             


Gln His Leu Arg Phe Leu Arg Glu Pro Val Val Thr Pro Gln Asp Leu 
    450                 455                 460                 


Glu Gly Pro Gly Arg Ala Glu Ser Lys Glu Ser Val Gly Ser Arg Asp 
465                 470                 475                 480 


Ser Ser Lys Arg Glu Gly Leu Leu Ala Thr His Pro Arg Pro Gly Gln 
                485                 490                 495     


Glu Arg Pro Gly Val Ala Arg Lys Glu Pro Ala Arg Ala Glu Ala Pro 
            500                 505                 510         


Arg Lys Thr Glu Lys Glu Ala Lys Thr Pro Arg Glu Leu Lys Lys Asp 
        515                 520                 525             


Pro Lys Pro Ser Val Ser Arg Thr Gln Pro Arg Glu Val Arg Arg Ala 
    530                 535                 540                 


Ala Ser Ser Val Pro Asn Leu Lys Lys Thr Asn Ala Gln Ala Ala Pro 
545                 550                 555                 560 


Lys Pro Arg Lys Ala Pro Ser Thr Ser His Ser Gly Phe Pro Pro Val 
                565                 570                 575     


Ala Asn Gly Pro Arg Ser Pro Pro Ser Leu Arg Cys Gly Glu Ala Ser 
            580                 585                 590         


Pro Pro Ser Ala Ala Cys Gly Ser Pro Ala Ser Gln Leu Val Ala Thr 
        595                 600                 605             


Pro Ser Leu Glu Leu Gly Pro Ile Pro Ala Gly Glu Glu Lys Ala Leu 
    610                 615                 620                 


Glu Leu Pro Leu Ala Ala Ser Ser Ile Pro Arg Pro Arg Thr Pro Ser 
625                 630                 635                 640 


Pro Glu Ser His Arg Ser Pro Ala Glu Gly Ser Glu Arg Leu Ser Leu 
                645                 650                 655     


Ser Pro Leu Arg Gly Gly Glu Ala Gly Pro Asp Ala Ser Pro Thr Val 
            660                 665                 670         


Thr Thr Pro Thr Val Thr Thr Pro Ser Leu Pro Ala Glu Val Gly Ser 
        675                 680                 685             


Pro His Ser Thr Glu Val Asp Glu Ser Leu Ser Val Ser Phe Glu Gln 
    690                 695                 700                 


Val Leu Pro Pro Ser Ala Pro Thr Ser Glu Ala Gly Leu Ser Leu Pro 
705                 710                 715                 720 


Leu Arg Gly Pro Arg Ala Arg Arg Ser Ala Ser Pro His Asp Val Asp 
                725                 730                 735     


Leu Cys Leu Val Ser Pro Cys Glu Phe Glu His Arg Lys Ala Val Pro 
            740                 745                 750         


Met Ala Pro Ala Pro Ala Ser Pro Gly Ser Ser Asn Asp Ser Ser Ala 
        755                 760                 765             


Arg Ser Gln Glu Arg Ala Gly Gly Leu Gly Ala Glu Glu Thr Pro Pro 
    770                 775                 780                 


Thr Ser Val Ser Glu Ser Leu Pro Thr Leu Ser Asp Ser Asp Pro Val 
785                 790                 795                 800 


Pro Leu Ala Pro Gly Ala Ala Asp Ser Asp Glu Asp Thr Glu Gly Phe 
                805                 810                 815     


Gly Val Pro Arg His Asp Pro Leu Pro Asp Pro Leu Lys Val Pro Pro 
            820                 825                 830         


Pro Leu Pro Asp Pro Ser Ser Ile Cys Met Val Asp Pro Glu Met Leu 
        835                 840                 845             


Pro Pro Lys Thr Ala Arg Gln Thr Glu Asn Val Ser Arg Thr Arg Lys 
    850                 855                 860                 


Pro Leu Ala Arg Pro Asn Ser Arg Ala Ala Ala Pro Lys Ala Thr Pro 
865                 870                 875                 880 


Val Ala Ala Ala Lys Thr Lys Gly Leu Ala Gly Gly Asp Arg Ala Ser 
                885                 890                 895     


Arg Pro Leu Ser Ala Arg Ser Glu Pro Ser Glu Lys Gly Gly Arg Ala 
            900                 905                 910         


Pro Leu Ser Arg Lys Ser Ser Thr Pro Lys Thr Ala Thr Arg Gly Pro 
        915                 920                 925             


Ser Gly Ser Ala Ser Ser Arg Pro Gly Val Ser Ala Thr Pro Pro Lys 
    930                 935                 940                 


Ser Pro Val Tyr Leu Asp Leu Ala Tyr Leu Pro Ser Gly Ser Ser Ala 
945                 950                 955                 960 


His Leu Val Asp Glu Glu Phe Phe Gln Arg Val Arg Ala Leu Cys Tyr 
                965                 970                 975     


Val Ile Ser Gly Gln Asp Gln Arg Lys Glu Glu Gly Met Arg Ala Val 
            980                 985                 990         


Leu Asp Ala Leu Leu Ala Ser Lys  Gln His Trp Asp Arg  Asp Leu Gln 
        995                 1000                 1005             


Val Thr  Leu Ile Pro Thr Phe  Asp Ser Val Ala Met  His Thr Trp 
    1010                 1015                 1020             


Tyr Ala  Glu Thr His Ala Arg  His Gln Ala Leu Gly  Ile Thr Val 
    1025                 1030                 1035             


Leu Gly  Ser Asn Ser Met Val  Ser Met Gln Asp Asp  Ala Phe Pro 
    1040                 1045                 1050             


Ala Cys  Lys Val Glu Phe 
    1055                 


<210> 5463
<211> 1577
<212> PRT
<213> Homo sapiens

<400> 5463
Met Glu Ala Gly Ser Val Val Arg Ala Ile Phe Asp Phe Cys Pro Ser 
1               5                   10                  15      


Val Ser Glu Glu Leu Pro Leu Phe Val Gly Asp Ile Ile Glu Val Leu 
            20                  25                  30          


Ala Val Val Asp Glu Phe Trp Leu Leu Gly Lys Lys Glu Asp Val Thr 
        35                  40                  45              


Gly Gln Phe Pro Ser Ser Phe Val Glu Ile Val Thr Ile Pro Ser Leu 
    50                  55                  60                  


Lys Glu Gly Glu Arg Leu Phe Val Cys Ile Cys Glu Phe Thr Ser Gln 
65                  70                  75                  80  


Glu Leu Asp Asn Leu Pro Leu His Arg Gly Asp Leu Val Ile Leu Asp 
                85                  90                  95      


Gly Ile Pro Thr Ala Gly Trp Leu Gln Gly Arg Ser Cys Trp Gly Ala 
            100                 105                 110         


Arg Gly Phe Phe Pro Ser Ser Cys Val Arg Glu Leu Cys Leu Ser Ser 
        115                 120                 125             


Gln Ser Arg Gln Trp His Ser Gln Ser Ala Leu Phe Gln Ile Pro Glu 
    130                 135                 140                 


Tyr Ser Met Gly Gln Ala Arg Ala Leu Met Gly Leu Ser Ala Gln Leu 
145                 150                 155                 160 


Asp Glu Glu Leu Asp Phe Arg Glu Gly Asp Val Ile Thr Ile Ile Gly 
                165                 170                 175     


Val Pro Glu Pro Gly Trp Phe Glu Gly Glu Leu Glu Gly Arg Arg Gly 
            180                 185                 190         


Ile Phe Pro Glu Gly Phe Val Glu Leu Leu Gly Pro Leu Arg Thr Val 
        195                 200                 205             


Asp Glu Ser Val Ser Ser Gly Asn Gln Asp Asp Cys Ile Val Asn Gly 
    210                 215                 220                 


Glu Val Asp Thr Pro Val Gly Glu Glu Glu Ile Gly Pro Asp Glu Asp 
225                 230                 235                 240 


Glu Glu Glu Pro Gly Thr Tyr Gly Val Ala Leu Tyr Arg Phe Gln Ala 
                245                 250                 255     


Leu Glu Pro Asn Glu Leu Asp Phe Glu Val Gly Asp Lys Ile Arg Ile 
            260                 265                 270         


Leu Ala Thr Leu Glu Asp Gly Trp Leu Glu Gly Ser Leu Lys Gly Arg 
        275                 280                 285             


Thr Gly Ile Phe Pro Tyr Arg Phe Val Lys Leu Cys Pro Asp Thr Arg 
    290                 295                 300                 


Val Glu Glu Thr Met Ala Leu Pro Gln Glu Gly Ser Leu Ala Arg Ile 
305                 310                 315                 320 


Pro Glu Thr Ser Leu Asp Cys Leu Glu Asn Thr Leu Gly Val Glu Glu 
                325                 330                 335     


Gln Arg His Glu Thr Ser Asp His Glu Ala Glu Glu Pro Asp Cys Ile 
            340                 345                 350         


Ile Ser Glu Ala Pro Thr Ser Pro Leu Gly His Leu Thr Ser Glu Tyr 
        355                 360                 365             


Asp Thr Asp Arg Asn Ser Tyr Gln Asp Glu Asp Thr Ala Gly Gly Pro 
    370                 375                 380                 


Pro Arg Ser Pro Gly Val Glu Trp Glu Met Pro Leu Ala Thr Asp Ser 
385                 390                 395                 400 


Pro Thr Ser Asp Pro Thr Glu Val Val Asn Gly Ile Ser Ser Gln Pro 
                405                 410                 415     


Gln Val Pro Phe His Pro Asn Leu Gln Lys Ser Gln Tyr Tyr Ser Thr 
            420                 425                 430         


Val Gly Gly Ser His Pro His Ser Glu Gln Tyr Pro Asp Leu Leu Pro 
        435                 440                 445             


Leu Glu Ala Arg Thr Arg Asp Tyr Ala Ser Leu Pro Pro Lys Arg Met 
    450                 455                 460                 


Tyr Ser Gln Leu Lys Thr Leu Gln Lys Pro Val Leu Pro Leu Tyr Arg 
465                 470                 475                 480 


Gly Ser Ser Val Ser Ala Ser Arg Val Val Lys Pro Arg Gln Ser Ser 
                485                 490                 495     


Pro Gln Leu His Asn Leu Ala Ser Tyr Thr Lys Lys His His Thr Ser 
            500                 505                 510         


Ser Val Tyr Ser Ile Ser Glu Arg Leu Glu Met Lys Pro Gly Pro Gln 
        515                 520                 525             


Ala Gln Gly Leu Val Met Glu Ala Ala Thr His Ser Gln Gly Asp Gly 
    530                 535                 540                 


Ser Thr Asp Leu Asp Ser Lys Leu Thr Gln Gln Leu Ile Glu Phe Glu 
545                 550                 555                 560 


Lys Ser Leu Ala Gly Pro Gly Thr Glu Pro Asp Lys Ile Leu Arg His 
                565                 570                 575     


Phe Ser Ile Met Asp Phe Asn Ser Glu Lys Asp Ile Val Arg Gly Ser 
            580                 585                 590         


Ser Lys Leu Ile Thr Glu Gln Glu Leu Pro Glu Arg Arg Lys Ala Leu 
        595                 600                 605             


Arg Pro Pro Pro Pro Arg Pro Cys Thr Pro Val Ser Thr Ser Pro His 
    610                 615                 620                 


Leu Leu Val Asp Gln Asn Leu Lys Pro Ala Pro Pro Leu Val Val Arg 
625                 630                 635                 640 


Pro Ser Arg Pro Ala Pro Leu Pro Pro Ser Ala Gln Gln Arg Thr Asn 
                645                 650                 655     


Ala Val Ser Pro Lys Leu Leu Ser Arg His Arg Pro Thr Cys Glu Thr 
            660                 665                 670         


Leu Glu Lys Glu Gly Pro Gly His Met Gly Arg Ser Leu Asp Gln Thr 
        675                 680                 685             


Ser Pro Cys Pro Leu Val Leu Val Arg Ile Glu Glu Met Glu Arg Asp 
    690                 695                 700                 


Leu Asp Met Tyr Ser Arg Ala Gln Glu Glu Leu Asn Leu Met Leu Glu 
705                 710                 715                 720 


Glu Lys Gln Asp Glu Ser Ser Arg Ala Glu Thr Leu Glu Asp Leu Lys 
                725                 730                 735     


Phe Cys Glu Ser Asn Ile Glu Ser Leu Asn Met Glu Leu Gln Gln Leu 
            740                 745                 750         


Arg Glu Met Thr Leu Leu Ser Ser Gln Ser Ser Ser Leu Val Ala Pro 
        755                 760                 765             


Ser Gly Ser Val Ser Ala Glu Asn Pro Glu Gln Arg Met Leu Glu Lys 
    770                 775                 780                 


Arg Ala Lys Val Ile Glu Glu Leu Leu Gln Thr Glu Arg Asp Tyr Ile 
785                 790                 795                 800 


Arg Asp Leu Glu Met Cys Ile Glu Arg Ile Met Val Pro Met Gln Gln 
                805                 810                 815     


Ala Gln Val Pro Asn Ile Asp Phe Glu Gly Leu Phe Gly Asn Met Gln 
            820                 825                 830         


Met Val Ile Lys Val Ser Lys Gln Leu Leu Ala Ala Leu Glu Ile Ser 
        835                 840                 845             


Asp Ala Val Gly Pro Val Phe Leu Gly His Arg Asp Glu Leu Glu Gly 
    850                 855                 860                 


Thr Tyr Lys Ile Tyr Cys Gln Asn His Asp Glu Ala Ile Ala Leu Leu 
865                 870                 875                 880 


Glu Ile Tyr Glu Lys Asp Glu Lys Ile Gln Lys His Leu Gln Asp Ser 
                885                 890                 895     


Leu Ala Asp Leu Lys Ser Leu Tyr Asn Glu Trp Gly Cys Thr Asn Tyr 
            900                 905                 910         


Ile Asn Leu Gly Ser Phe Leu Ile Lys Pro Val Gln Arg Val Met Arg 
        915                 920                 925             


Tyr Pro Leu Leu Leu Met Glu Leu Leu Asn Ser Thr Pro Glu Ser His 
    930                 935                 940                 


Pro Asp Lys Val Pro Leu Thr Asn Ala Val Leu Ala Val Lys Glu Ile 
945                 950                 955                 960 


Asn Val Asn Ile Asn Glu Tyr Lys Arg Arg Lys Asp Leu Val Leu Lys 
                965                 970                 975     


Tyr Arg Lys Gly Asp Glu Asp Ser Leu Met Glu Lys Ile Ser Lys Leu 
            980                 985                 990         


Asn Ile His Ser Ile Ile Lys Lys  Ser Asn Arg Val Ser  Ser His Leu 
        995                 1000                 1005             


Lys His  Leu Thr Gly Phe Ala  Pro Gln Ile Lys Asp  Glu Val Phe 
    1010                 1015                 1020             


Glu Glu  Thr Glu Lys Asn Phe  Arg Met Gln Glu Arg  Leu Ile Lys 
    1025                 1030                 1035             


Ser Phe  Ile Arg Asp Leu Ser  Leu Tyr Leu Gln His  Ile Arg Glu 
    1040                 1045                 1050             


Ser Ala  Cys Val Lys Val Val  Ala Ala Val Ser Met  Trp Asp Val 
    1055                 1060                 1065             


Cys Met  Glu Arg Gly His Arg  Asp Leu Glu Gln Phe  Glu Arg Val 
    1070                 1075                 1080             


His Arg  Tyr Ile Ser Asp Gln  Leu Phe Thr Asn Phe  Lys Glu Arg 
    1085                 1090                 1095             


Thr Glu  Arg Leu Val Ile Ser  Pro Leu Asn Gln Leu  Leu Ser Met 
    1100                 1105                 1110             


Phe Thr  Gly Pro His Lys Leu  Val Gln Lys Arg Phe  Asp Lys Leu 
    1115                 1120                 1125             


Leu Asp  Phe Tyr Asn Cys Thr  Glu Arg Ala Glu Lys  Leu Lys Asp 
    1130                 1135                 1140             


Lys Lys  Thr Leu Glu Glu Leu  Gln Ser Ala Arg Asn  Asn Tyr Glu 
    1145                 1150                 1155             


Ala Leu  Asn Ala Gln Leu Leu  Asp Glu Leu Pro Lys  Phe His Gln 
    1160                 1165                 1170             


Tyr Ala  Gln Gly Leu Phe Thr  Asn Cys Val His Gly  Tyr Ala Glu 
    1175                 1180                 1185             


Ala His  Cys Asp Phe Val His  Gln Ala Leu Glu Gln  Leu Lys Pro 
    1190                 1195                 1200             


Leu Leu  Ser Leu Leu Lys Val  Ala Gly Arg Glu Gly  Asn Leu Ile 
    1205                 1210                 1215             


Ala Ile  Phe His Glu Glu His  Ser Arg Val Leu Gln  Gln Leu Gln 
    1220                 1225                 1230             


Val Phe  Thr Phe Phe Pro Glu  Ser Leu Pro Ala Thr  Lys Lys Pro 
    1235                 1240                 1245             


Phe Glu  Arg Lys Thr Ile Asp  Arg Gln Ser Ala Arg  Lys Pro Leu 
    1250                 1255                 1260             


Leu Gly  Leu Pro Ser Tyr Met  Leu Gln Ser Glu Glu  Leu Arg Ala 
    1265                 1270                 1275             


Ser Leu  Leu Ala Arg Tyr Pro  Pro Glu Lys Leu Phe  Gln Ala Glu 
    1280                 1285                 1290             


Arg Asn  Phe Asn Ala Ala Gln  Asp Leu Asp Val Ser  Leu Leu Glu 
    1295                 1300                 1305             


Gly Asp  Leu Val Gly Val Ile  Lys Lys Lys Asp Pro  Met Gly Ser 
    1310                 1315                 1320             


Gln Asn  Arg Trp Leu Ile Asp  Asn Gly Val Thr Lys  Gly Phe Val 
    1325                 1330                 1335             


Tyr Ser  Ser Phe Leu Lys Pro  Tyr Asn Pro Arg Arg  Ser His Ser 
    1340                 1345                 1350             


Asp Ala  Ser Val Gly Ser His  Ser Ser Thr Glu Ser  Glu His Gly 
    1355                 1360                 1365             


Ser Ser  Ser Pro Arg Phe Pro  Arg Gln Asn Ser Gly  Ser Thr Leu 
    1370                 1375                 1380             


Thr Phe  Asn Pro Ser Ser Met  Ala Val Ser Phe Thr  Ser Gly Ser 
    1385                 1390                 1395             


Cys Gln  Lys Gln Pro Gln Asp  Ala Ser Pro Pro Pro  Lys Glu Cys 
    1400                 1405                 1410             


Asp Gln  Gly Thr Leu Ser Ala  Ser Leu Asn Pro Ser  Asn Ser Glu 
    1415                 1420                 1425             


Ser Ser  Pro Ser Arg Cys Pro  Ser Asp Pro Asp Ser  Thr Ser Gln 
    1430                 1435                 1440             


Pro Arg  Ser Gly Asp Ser Ala  Asp Val Ala Arg Asp  Val Lys Gln 
    1445                 1450                 1455             


Pro Thr  Ala Thr Pro Arg Ser  Tyr Arg Asn Phe Arg  His Pro Glu 
    1460                 1465                 1470             


Ile Val  Gly Tyr Ser Val Pro  Gly Arg Asn Gly Gln  Ser Gln Asp 
    1475                 1480                 1485             


Leu Val  Lys Gly Cys Ala Arg  Thr Ala Gln Ala Pro  Glu Asp Arg 
    1490                 1495                 1500             


Ser Thr  Glu Pro Asp Gly Ser  Glu Ala Glu Gly Asn  Gln Val Tyr 
    1505                 1510                 1515             


Phe Ala  Val Tyr Thr Phe Lys  Ala Arg Asn Pro Asn  Glu Leu Ser 
    1520                 1525                 1530             


Val Ser  Ala Asn Gln Lys Leu  Lys Ile Leu Glu Phe  Lys Asp Val 
    1535                 1540                 1545             


Thr Gly  Asn Thr Glu Trp Trp  Leu Ala Glu Val Asn  Gly Lys Lys 
    1550                 1555                 1560             


Gly Tyr  Val Pro Ser Asn Tyr  Ile Arg Lys Thr Glu  Tyr Thr 
    1565                 1570                 1575         


<210> 5464
<211> 1061
<212> PRT
<213> Homo sapiens

<400> 5464
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Lys 
    850                 855                 860                 


Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr Leu 
865                 870                 875                 880 


Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu Leu 
                885                 890                 895     


Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro Thr 
            900                 905                 910         


Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser Ala 
        915                 920                 925             


Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu Arg 
    930                 935                 940                 


Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp Leu 
945                 950                 955                 960 


Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu Trp 
                965                 970                 975     


Leu Asp Ser Cys Gly Leu Thr Ala Lys Ala Cys Glu Asn Leu Tyr Phe 
            980                 985                 990         


Thr Leu Gly Ile Asn Gln Thr Leu  Thr Asp Leu Tyr Leu  Thr Asn Asn 
        995                 1000                 1005             


Ala Leu  Gly Asp Thr Gly Val  Arg Leu Leu Cys Lys  Arg Leu Ser 
    1010                 1015                 1020             


His Pro  Gly Cys Lys Leu Arg  Val Leu Trp Leu Phe  Gly Met Asp 
    1025                 1030                 1035             


Leu Asn  Lys Met Thr His Ser  Arg Leu Ala Ala Leu  Arg Val Thr 
    1040                 1045                 1050             


Lys Pro  Tyr Leu Asp Ile Gly  Cys 
    1055                 1060     


<210> 5465
<211> 1320
<212> PRT
<213> Homo sapiens

<400> 5465
Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Ile Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp 
        115                 120                 125             


Trp Ile Ala Tyr Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ile His His Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Tyr Arg Ser Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys 
            260                 265                 270         


Asn Tyr Met Gln Arg Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln 
                325                 330                 335     


Glu Gly Glu Pro Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu 
            340                 345                 350         


Arg Arg Asp Phe Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu 
        355                 360                 365             


Ala Leu Arg Arg Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln 
    370                 375                 380                 


Glu Glu Tyr Lys Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu 
385                 390                 395                 400 


Gln Gln Lys Glu Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu 
                405                 410                 415     


Arg Glu Ala Arg Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln 
            420                 425                 430         


Glu Glu Lys Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu 
        435                 440                 445             


Glu Glu Arg Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu 
    450                 455                 460                 


Gln Glu Tyr Ile Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu 
465                 470                 475                 480 


Val Leu Gln Gln Gln Leu Leu Gln Glu Gln Ala Met Leu Leu Glu Cys 
                485                 490                 495     


Arg Trp Arg Glu Met Glu Glu His Arg Gln Ala Glu Arg Leu Gln Arg 
            500                 505                 510         


Gln Leu Gln Gln Glu Gln Ala Tyr Leu Leu Ser Leu Gln His Asp His 
        515                 520                 525             


Arg Arg Pro His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln Gln 
    530                 535                 540                 


Glu Arg Ser Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr 
545                 550                 555                 560 


Glu Pro Ala Asp Arg Ala Arg Glu Val Glu Asp Arg Phe Arg Lys Thr 
                565                 570                 575     


Asn His Ser Ser Pro Glu Ala Gln Ser Lys Gln Thr Gly Arg Val Leu 
            580                 585                 590         


Glu Pro Pro Val Pro Ser Arg Ser Glu Ser Phe Ser Asn Gly Asn Ser 
        595                 600                 605             


Glu Ser Val His Pro Ala Leu Gln Arg Pro Ala Glu Pro Gln Val Gln 
    610                 615                 620                 


Trp Ser His Leu Ala Ser Leu Lys Asn Asn Val Ser Pro Val Ser Arg 
625                 630                 635                 640 


Ser His Ser Phe Ser Asp Pro Ser Pro Lys Phe Ala His His His Leu 
                645                 650                 655     


Arg Ser Gln Asp Pro Cys Pro Pro Ser Arg Ser Glu Val Leu Ser Gln 
            660                 665                 670         


Ser Ser Asp Ser Lys Ser Glu Ala Pro Asp Pro Thr Gln Lys Ala Trp 
        675                 680                 685             


Ser Arg Ser Asp Ser Asp Glu Val Pro Pro Arg Val Pro Val Arg Thr 
    690                 695                 700                 


Thr Ser Arg Ser Pro Val Leu Ser Arg Arg Asp Ser Pro Leu Gln Gly 
705                 710                 715                 720 


Ser Gly Gln Gln Asn Ser Gln Ala Gly Gln Arg Asn Ser Thr Ser Ser 
                725                 730                 735     


Ile Glu Pro Arg Leu Leu Trp Glu Arg Val Glu Lys Leu Val Pro Arg 
            740                 745                 750         


Pro Gly Ser Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly Ser Gln Pro 
        755                 760                 765             


Gly Ser His Pro Gly Ser Gln Ser Gly Ser Gly Glu Arg Phe Arg Val 
    770                 775                 780                 


Arg Ser Ser Ser Lys Ser Glu Gly Ser Pro Ser Gln Arg Leu Glu Asn 
785                 790                 795                 800 


Ala Val Lys Lys Pro Glu Asp Lys Lys Glu Val Phe Arg Pro Leu Lys 
                805                 810                 815     


Pro Ala Val Arg Ile Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala 
            820                 825                 830         


Val Glu Asp Val Arg Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser 
        835                 840                 845             


Ser Glu Glu Ser Gly Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gln 
    850                 855                 860                 


Glu Gly Ala Asp Glu Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala 
865                 870                 875                 880 


Ser Ser Leu Asn Leu Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met 
                885                 890                 895     


Ile Val His Asp Asp Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys 
            900                 905                 910         


Glu Gly Thr Leu Ile Val Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu 
        915                 920                 925             


Gln Lys His Lys Ser Ser Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg 
    930                 935                 940                 


Leu Leu Gln Ile Ser Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val 
945                 950                 955                 960 


Gly Phe Ser Cys Asp Gly Met Arg Pro Glu Ala Ile Arg Gln Asp Pro 
                965                 970                 975     


Thr Arg Lys Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro 
            980                 985                 990         


Gln Ser Asp Thr Pro Glu Ile Arg  Lys Tyr Lys Lys Arg  Phe Asn Ser 
        995                 1000                 1005             


Glu Ile  Leu Cys Ala Ala Leu  Trp Gly Val Asn Leu  Leu Val Gly 
    1010                 1015                 1020             


Thr Glu  Ser Gly Leu Met Leu  Leu Asp Arg Ser Gly  Gln Gly Lys 
    1025                 1030                 1035             


Val Tyr  Pro Leu Ile Asn Arg  Arg Arg Phe Gln Gln  Met Asp Val 
    1040                 1045                 1050             


Leu Glu  Gly Leu Asn Val Leu  Val Thr Ile Ser Gly  Lys Lys Asp 
    1055                 1060                 1065             


Lys Leu  Arg Val Tyr Tyr Leu  Ser Trp Leu Arg Asn  Lys Ile Leu 
    1070                 1075                 1080             


His Asn  Asp Pro Glu Val Glu  Lys Lys Gln Gly Trp  Thr Thr Val 
    1085                 1090                 1095             


Gly Asp  Leu Glu Gly Cys Val  His Tyr Lys Val Val  Lys Tyr Glu 
    1100                 1105                 1110             


Arg Ile  Lys Phe Leu Val Ile  Ala Leu Lys Ser Ser  Val Glu Val 
    1115                 1120                 1125             


Tyr Ala  Trp Ala Pro Lys Pro  Tyr His Lys Phe Met  Ala Phe Lys 
    1130                 1135                 1140             


Ser Phe  Gly Glu Leu Val His  Lys Pro Leu Leu Val  Asp Leu Thr 
    1145                 1150                 1155             


Val Glu  Glu Gly Gln Arg Leu  Lys Val Ile Tyr Gly  Ser Cys Ala 
    1160                 1165                 1170             


Gly Phe  His Ala Val Asp Val  Asp Ser Gly Ser Val  Tyr Asp Ile 
    1175                 1180                 1185             


Tyr Leu  Pro Thr His Ile Gln  Cys Ser Ile Lys Pro  His Ala Ile 
    1190                 1195                 1200             


Ile Ile  Leu Pro Asn Thr Asp  Gly Met Glu Leu Leu  Val Cys Tyr 
    1205                 1210                 1215             


Glu Asp  Glu Gly Val Tyr Val  Asn Thr Tyr Gly Arg  Ile Thr Lys 
    1220                 1225                 1230             


Asp Val  Val Leu Gln Trp Gly  Glu Met Pro Thr Ser  Val Ala Tyr 
    1235                 1240                 1245             


Ile Arg  Ser Asn Gln Thr Met  Gly Trp Gly Glu Lys  Ala Ile Glu 
    1250                 1255                 1260             


Ile Arg  Ser Val Glu Thr Gly  His Leu Asp Gly Val  Phe Met His 
    1265                 1270                 1275             


Lys Arg  Ala Gln Arg Leu Lys  Phe Leu Cys Glu Arg  Asn Asp Lys 
    1280                 1285                 1290             


Val Phe  Phe Ala Ser Val Arg  Ser Gly Gly Ser Ser  Gln Val Tyr 
    1295                 1300                 1305             


Phe Met  Thr Leu Gly Arg Thr  Ser Leu Leu Ser Trp  
    1310                 1315                 1320 


<210> 5466
<211> 201
<212> PRT
<213> Homo sapiens

<400> 5466
Met Tyr Thr Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
1               5                   10                  15      


Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
            20                  25                  30          


Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys Asn Tyr Lys Gly Met 
        35                  40                  45              


Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu Asn Ile Gly Thr Val 
    50                  55                  60                  


Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
65                  70                  75                  80  


Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                85                  90                  95      


Ile Tyr Val Ile Asp Ser Thr Asp Glu Glu Arg Leu Ala Glu Ser Lys 
            100                 105                 110         


Gln Ala Phe Glu Lys Val Val Thr Ser Glu Ala Leu Cys Gly Val Pro 
        115                 120                 125             


Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Thr Cys Leu Ser Ile 
    130                 135                 140                 


Pro Asp Ile Lys Thr Ala Phe Ser Asp Cys Thr Ser Lys Ile Gly Arg 
145                 150                 155                 160 


Arg Asp Cys Leu Thr Gln Ala Cys Ser Ala Leu Thr Gly Lys Gly Val 
                165                 170                 175     


Arg Glu Gly Ile Glu Trp Met Val Lys Cys Val Val Arg Asn Val His 
            180                 185                 190         


Arg Pro Pro Arg Gln Arg Asp Ile Thr 
        195                 200     


<210> 5467
<211> 442
<212> PRT
<213> Homo sapiens

<400> 5467
Met Arg Gly Ala Met Glu Leu Glu Pro Glu Leu Leu Leu Gln Glu Ala 
1               5                   10                  15      


Arg Glu Asn Val Glu Ala Ala Gln Ser Tyr Arg Arg Glu Leu Gly His 
            20                  25                  30          


Arg Leu Glu Gly Leu Arg Glu Ala Arg Arg Gln Ile Lys Glu Ser Ala 
        35                  40                  45              


Ser Gln Thr Arg Asp Val Leu Lys Gln His Phe Asn Asp Leu Lys Gly 
    50                  55                  60                  


Thr Leu Gly Lys Leu Leu Asp Glu Arg Leu Val Thr Leu Leu Gln Glu 
65                  70                  75                  80  


Val Asp Thr Ile Glu Gln Glu Thr Ile Lys Pro Leu Asp Asp Cys Gln 
                85                  90                  95      


Lys Leu Ile Glu His Gly Val Asn Thr Ala Glu Asp Leu Val Arg Glu 
            100                 105                 110         


Gly Glu Ile Ala Met Leu Gly Gly Val Gly Glu Glu Asn Glu Lys Leu 
        115                 120                 125             


Trp Ser Phe Thr Lys Lys Ala Ser His Ile Gln Leu Asp Ser Leu Pro 
    130                 135                 140                 


Glu Val Pro Leu Leu Val Asp Val Pro Cys Leu Ser Ala Gln Leu Asp 
145                 150                 155                 160 


Asp Ser Ile Leu Asn Ile Val Lys Asp His Ile Phe Lys His Gly Thr 
                165                 170                 175     


Val Ala Ser Arg Pro Pro Val Gln Ile Glu Glu Leu Ile Glu Lys Pro 
            180                 185                 190         


Gly Gly Ile Ile Val Arg Trp Cys Lys Val Asp Asp Asp Phe Thr Ala 
        195                 200                 205             


Gln Asp Tyr Arg Leu Gln Phe Arg Lys Cys Thr Ser Asn His Phe Glu 
    210                 215                 220                 


Asp Val Tyr Val Gly Ser Glu Thr Glu Phe Ile Val Leu His Ile Asp 
225                 230                 235                 240 


Pro Asn Val Asp Tyr Gln Phe Arg Val Cys Ala Arg Gly Asp Gly Arg 
                245                 250                 255     


Gln Glu Trp Ser Pro Trp Ser Val Pro Gln Ile Gly His Ser Thr Leu 
            260                 265                 270         


Val Pro His Glu Trp Thr Ala Gly Phe Glu Gly Tyr Ser Leu Ser Ser 
        275                 280                 285             


Arg Arg Asn Ile Ala Leu Arg Asn Asp Ser Glu Ser Ser Gly Val Leu 
    290                 295                 300                 


Tyr Ser Arg Ala Pro Thr Tyr Phe Cys Gly Gln Thr Leu Thr Phe Arg 
305                 310                 315                 320 


Val Glu Thr Val Gly Gln Pro Asp Arg Arg Asp Ser Ile Gly Val Cys 
                325                 330                 335     


Ala Glu Lys Gln Asp Gly Tyr Asp Ser Leu Gln Arg Asp Gln Ala Val 
            340                 345                 350         


Cys Ile Ser Thr Asn Gly Ala Val Phe Val Asn Gly Lys Glu Met Thr 
        355                 360                 365             


Asn Gln Leu Pro Ala Val Thr Ser Gly Ser Thr Val Thr Phe Asp Ile 
    370                 375                 380                 


Glu Ala Val Thr Leu Gly Thr Thr Ser Asn Asn Glu Gly Gly His Phe 
385                 390                 395                 400 


Lys Leu Arg Val Thr Ile Ser Ser Asn Asn Arg Glu Val Val Phe Asp 
                405                 410                 415     


Trp Leu Leu Asp Gln Ser Cys Gly Ser Leu Tyr Phe Gly Cys Ser Phe 
            420                 425                 430         


Phe Tyr Pro Gly Trp Lys Val Leu Val Phe 
        435                 440         


<210> 5468
<211> 475
<212> PRT
<213> Homo sapiens

<400> 5468
Met Ala Ala Leu Thr Thr Leu Phe Lys Tyr Ile Asp Glu Asn Gln Asp 
1               5                   10                  15      


Arg Tyr Ile Lys Lys Leu Ala Lys Trp Val Ala Ile Gln Ser Val Ser 
            20                  25                  30          


Ala Trp Pro Glu Lys Arg Gly Glu Ile Arg Arg Met Met Glu Val Ala 
        35                  40                  45              


Ala Ala Asp Val Lys Gln Leu Gly Gly Ser Val Glu Leu Val Asp Ile 
    50                  55                  60                  


Gly Lys Gln Lys Leu Pro Asp Gly Ser Glu Ile Pro Leu Pro Pro Ile 
65                  70                  75                  80  


Leu Leu Gly Arg Leu Gly Ser Asp Pro Gln Lys Lys Thr Val Cys Ile 
                85                  90                  95      


Tyr Gly His Leu Asp Val Gln Pro Ala Ala Leu Glu Asp Gly Trp Asp 
            100                 105                 110         


Ser Glu Pro Phe Thr Leu Val Glu Arg Asp Gly Lys Leu Tyr Gly Arg 
        115                 120                 125             


Gly Ser Thr Asp Asp Lys Gly Pro Val Ala Gly Trp Ile Asn Ala Leu 
    130                 135                 140                 


Glu Ala Tyr Gln Lys Thr Gly Gln Glu Ile Pro Val Asn Val Arg Phe 
145                 150                 155                 160 


Cys Leu Glu Gly Met Glu Glu Ser Gly Ser Glu Gly Leu Asp Glu Leu 
                165                 170                 175     


Ile Phe Ala Arg Lys Asp Thr Phe Phe Lys Asp Val Asp Tyr Val Cys 
            180                 185                 190         


Ile Ser Asp Asn Tyr Trp Leu Gly Lys Lys Lys Pro Cys Ile Thr Tyr 
        195                 200                 205             


Gly Leu Arg Gly Ile Cys Tyr Phe Phe Ile Glu Val Glu Cys Ser Asn 
    210                 215                 220                 


Lys Asp Leu His Ser Gly Val Tyr Gly Gly Ser Val His Glu Ala Met 
225                 230                 235                 240 


Thr Asp Leu Ile Leu Leu Met Gly Ser Leu Val Asp Lys Arg Gly Asn 
                245                 250                 255     


Ile Leu Ile Pro Gly Ile Asn Glu Ala Val Ala Ala Val Thr Glu Glu 
            260                 265                 270         


Glu His Lys Leu Tyr Asp Asp Ile Asp Phe Asp Ile Glu Glu Phe Ala 
        275                 280                 285             


Lys Asp Val Gly Ala Gln Ile Leu Leu His Ser His Lys Lys Asp Ile 
    290                 295                 300                 


Leu Met His Arg Trp Arg Tyr Pro Ser Leu Ser Leu His Gly Ile Glu 
305                 310                 315                 320 


Gly Ala Phe Ser Gly Ser Gly Ala Lys Thr Val Ile Pro Arg Lys Val 
                325                 330                 335     


Val Gly Lys Phe Ser Ile Arg Leu Val Pro Asn Met Thr Pro Glu Val 
            340                 345                 350         


Val Gly Glu Gln Val Thr Ser Tyr Leu Thr Lys Lys Phe Ala Glu Leu 
        355                 360                 365             


Arg Ser Pro Asn Glu Phe Lys Val Tyr Met Gly His Gly Gly Lys Pro 
    370                 375                 380                 


Trp Val Ser Asp Phe Ser His Pro His Tyr Leu Ala Gly Arg Arg Ala 
385                 390                 395                 400 


Met Lys Thr Val Phe Gly Val Glu Pro Asp Leu Thr Arg Glu Gly Gly 
                405                 410                 415     


Ser Ile Pro Val Thr Leu Thr Phe Gln Glu Ala Thr Gly Lys Asn Val 
            420                 425                 430         


Met Leu Leu Pro Val Gly Ser Ala Asp Asp Gly Ala His Ser Gln Asn 
        435                 440                 445             


Glu Lys Leu Asn Arg Tyr Asn Tyr Ile Glu Gly Thr Lys Met Leu Ala 
    450                 455                 460                 


Ala Tyr Leu Tyr Glu Val Ser Gln Leu Lys Asp 
465                 470                 475 


<210> 5469
<211> 2096
<212> PRT
<213> Homo sapiens

<400> 5469
Met Ala Glu Val Thr Val Pro Arg Val Tyr Val Val Phe Gly Ile His 
1               5                   10                  15      


Cys Ile Met Ala Lys Ala Ser Ser Asp Val Gln Val Ser Gly Phe His 
            20                  25                  30          


Arg Lys Ile Gln His Val Lys Asn Glu Leu Cys His Met Leu Ser Leu 
        35                  40                  45              


Glu Glu Val Ala Pro Val Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu 
    50                  55                  60                  


Leu Gly Arg Val His Phe Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile 
65                  70                  75                  80  


Leu Ser Arg Thr Leu Ser Asn Glu Glu His Phe Gln Glu Pro Asp Cys 
                85                  90                  95      


Ser Leu Glu Ala Gln Pro Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly 
            100                 105                 110         


Arg Arg Ser Leu Pro Glu Phe Gln Glu Ser Val Glu Glu Phe Pro Glu 
        115                 120                 125             


Val Thr Val Ile Glu Pro Leu Asp Glu Glu Ala Arg Pro Ser His Ile 
    130                 135                 140                 


Pro Ala Gly Asp Cys Ser Glu His Trp Lys Thr Gln Arg Ser Glu Glu 
145                 150                 155                 160 


Tyr Glu Ala Glu Gly Gln Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn 
                165                 170                 175     


Ala Ser Gln Ser Gly Ser Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys 
            180                 185                 190         


Leu Gln Glu Val Cys Glu Asp Leu Gly Ile Thr Arg Asp Gly His Leu 
        195                 200                 205             


Asn Arg Lys Lys Leu Val Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn 
    210                 215                 220                 


Val Asp Gly Glu Met Leu Glu Glu Val Phe His Asn Leu Asp Pro Asp 
225                 230                 235                 240 


Gly Thr Met Ser Val Glu Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly 
                245                 250                 255     


Lys Ser Leu Thr Pro Ser Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg 
            260                 265                 270         


His Leu Ser Met Gln Ser Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr 
        275                 280                 285             


Ser Ser Ala Met Thr Ser Thr Ile Gly Phe Arg Val Phe Ser Cys Leu 
    290                 295                 300                 


Asp Asp Gly Met Gly His Ala Ser Val Glu Arg Ile Leu Asp Thr Trp 
305                 310                 315                 320 


Gln Glu Glu Gly Ile Glu Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp 
                325                 330                 335     


Phe Ser Leu Asp Gly Asn Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu 
            340                 345                 350         


Glu Asn Glu Leu Leu Val Thr Lys Asn Ser Ile His Gln Ala Ala Leu 
        355                 360                 365             


Ala Ser Phe Lys Ala Glu Ile Arg His Leu Leu Glu Arg Val Asp Gln 
    370                 375                 380                 


Val Val Arg Glu Lys Glu Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu 
385                 390                 395                 400 


Lys Leu Lys Ser Leu Met Ala Ser Glu Val Asp Asp His His Ala Ala 
                405                 410                 415     


Ile Glu Arg Arg Asn Glu Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr 
            420                 425                 430         


Lys Glu Arg Ile Ala Ala Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu 
        435                 440                 445             


Gln Ile Leu Gln Gln Ala Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu 
    450                 455                 460                 


Ile Glu Lys Ala Lys Thr Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala 
465                 470                 475                 480 


Leu Ser Leu Lys Glu Asn Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn 
                485                 490                 495     


Ala Glu Lys Leu Ala Glu Tyr Glu Asn Leu Thr Asn Lys Leu Gln Arg 
            500                 505                 510         


Asn Leu Glu Asn Val Leu Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser 
        515                 520                 525             


Ser Ala Glu Phe Phe Leu Gln Glu Glu Arg Leu Thr Gln Met Arg Asn 
    530                 535                 540                 


Glu Tyr Glu Arg Gln Cys Arg Val Leu Gln Asp Gln Val Asp Glu Leu 
545                 550                 555                 560 


Gln Ser Glu Leu Glu Glu Tyr Arg Ala Gln Gly Arg Val Leu Arg Leu 
                565                 570                 575     


Pro Leu Lys Asn Ser Pro Ser Glu Glu Val Glu Ala Asn Ser Gly Gly 
            580                 585                 590         


Ile Glu Pro Glu His Gly Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn 
        595                 600                 605             


Met Ser Ile Glu Ala Glu Leu Val Ile Glu Gln Met Lys Glu Gln His 
    610                 615                 620                 


His Arg Asp Ile Cys Cys Leu Arg Leu Glu Leu Glu Asp Lys Val Arg 
625                 630                 635                 640 


His Tyr Glu Lys Gln Leu Asp Glu Thr Val Val Ser Cys Lys Lys Ala 
                645                 650                 655     


Gln Glu Asn Met Lys Gln Arg His Glu Asn Glu Thr His Thr Leu Glu 
            660                 665                 670         


Lys Gln Ile Ser Asp Leu Lys Asn Glu Ile Ala Glu Leu Gln Gly Gln 
        675                 680                 685             


Ala Ala Val Leu Lys Glu Ala His His Glu Ala Thr Cys Arg His Glu 
    690                 695                 700                 


Glu Glu Lys Lys Gln Leu Gln Val Lys Leu Glu Glu Glu Lys Thr His 
705                 710                 715                 720 


Leu Gln Glu Lys Leu Arg Leu Gln His Glu Met Glu Leu Lys Ala Arg 
                725                 730                 735     


Leu Thr Gln Ala Gln Ala Ser Phe Glu Arg Glu Arg Glu Gly Leu Gln 
            740                 745                 750         


Ser Ser Ala Trp Thr Glu Glu Lys Val Arg Gly Leu Thr Gln Glu Leu 
        755                 760                 765             


Glu Gln Phe His Gln Glu Gln Leu Thr Ser Leu Val Glu Lys His Thr 
    770                 775                 780                 


Leu Glu Lys Glu Glu Leu Arg Lys Glu Leu Leu Glu Lys His Gln Arg 
785                 790                 795                 800 


Glu Leu Gln Glu Gly Arg Glu Lys Met Glu Thr Glu Cys Asn Arg Arg 
                805                 810                 815     


Thr Ser Gln Ile Glu Ala Gln Phe Gln Ser Asp Cys Gln Lys Val Thr 
            820                 825                 830         


Glu Arg Cys Glu Ser Ala Leu Gln Ser Leu Glu Gly Arg Tyr Arg Gln 
        835                 840                 845             


Glu Leu Lys Asp Leu Gln Glu Gln Gln Arg Glu Glu Lys Ser Gln Trp 
    850                 855                 860                 


Glu Phe Glu Lys Asp Glu Leu Thr Gln Glu Cys Ala Glu Ala Gln Glu 
865                 870                 875                 880 


Leu Leu Lys Glu Thr Leu Lys Arg Glu Lys Thr Thr Ser Leu Val Leu 
                885                 890                 895     


Thr Gln Glu Arg Glu Met Leu Glu Lys Thr Tyr Lys Glu His Leu Asn 
            900                 905                 910         


Ser Met Val Val Glu Arg Gln Gln Leu Leu Gln Asp Leu Glu Asp Leu 
        915                 920                 925             


Arg Asn Val Ser Glu Thr Gln Gln Ser Leu Leu Ser Asp Gln Ile Leu 
    930                 935                 940                 


Glu Leu Lys Ser Ser His Lys Arg Glu Leu Arg Glu Arg Glu Glu Val 
945                 950                 955                 960 


Leu Cys Gln Ala Gly Ala Ser Glu Gln Leu Ala Ser Gln Arg Leu Glu 
                965                 970                 975     


Arg Leu Glu Met Glu His Asp Gln Glu Arg Gln Glu Met Met Ser Lys 
            980                 985                 990         


Leu Leu Ala Met Glu Asn Ile His  Lys Ala Thr Cys Glu  Thr Ala Asp 
        995                 1000                 1005             


Arg Glu  Arg Ala Glu Met Ser  Thr Glu Ile Ser Arg  Leu Gln Ser 
    1010                 1015                 1020             


Lys Ile  Lys Glu Met Gln Gln  Ala Thr Ser Pro Leu  Ser Met Leu 
    1025                 1030                 1035             


Gln Ser  Gly Cys Gln Val Ile  Gly Glu Glu Glu Val  Glu Gly Asp 
    1040                 1045                 1050             


Gly Ala  Leu Ser Leu Leu Gln  Gln Gly Glu Gln Leu  Leu Glu Glu 
    1055                 1060                 1065             


Asn Gly  Asp Val Leu Leu Ser  Leu Gln Arg Ala His  Glu Gln Ala 
    1070                 1075                 1080             


Val Lys  Glu Asn Val Lys Met  Ala Thr Glu Ile Ser  Arg Leu Gln 
    1085                 1090                 1095             


Gln Arg  Leu Gln Lys Leu Glu  Pro Gly Leu Val Met  Ser Ser Cys 
    1100                 1105                 1110             


Leu Asp  Glu Pro Ala Thr Glu  Phe Phe Gly Asn Thr  Ala Glu Gln 
    1115                 1120                 1125             


Thr Glu  Gln Phe Leu Gln Gln  Asn Arg Thr Lys Gln  Val Glu Gly 
    1130                 1135                 1140             


Val Thr  Arg Arg His Val Leu  Ser Asp Leu Glu Asp  Asp Glu Val 
    1145                 1150                 1155             


Arg Asp  Leu Gly Ser Thr Gly  Thr Ser Ser Val Gln  Arg Gln Glu 
    1160                 1165                 1170             


Val Lys  Ile Glu Glu Ser Glu  Ala Ser Val Glu Gly  Phe Ser Glu 
    1175                 1180                 1185             


Leu Glu  Asn Ser Glu Glu Thr  Arg Thr Glu Ser Trp  Glu Leu Lys 
    1190                 1195                 1200             


Asn Gln  Ile Ser Gln Leu Gln  Glu Gln Leu Met Met  Leu Cys Ala 
    1205                 1210                 1215             


Asp Cys  Asp Arg Ala Ser Glu  Lys Lys Gln Asp Leu  Leu Phe Asp 
    1220                 1225                 1230             


Val Ser  Val Leu Lys Lys Lys  Leu Lys Met Leu Glu  Arg Ile Pro 
    1235                 1240                 1245             


Glu Ala  Ser Pro Lys Tyr Lys  Leu Leu Tyr Glu Asp  Val Ser Arg 
    1250                 1255                 1260             


Glu Asn  Asp Cys Leu Gln Glu  Glu Leu Arg Met Met  Glu Thr Arg 
    1265                 1270                 1275             


Tyr Asp  Glu Ala Leu Glu Asn  Asn Lys Glu Leu Thr  Ala Glu Val 
    1280                 1285                 1290             


Phe Arg  Leu Gln Asp Glu Leu  Lys Lys Met Glu Glu  Val Thr Glu 
    1295                 1300                 1305             


Thr Phe  Leu Ser Leu Glu Lys  Ser Tyr Asp Glu Val  Lys Ile Glu 
    1310                 1315                 1320             


Asn Glu  Gly Leu Asn Val Leu  Val Leu Arg Leu Gln  Gly Lys Ile 
    1325                 1330                 1335             


Glu Lys  Leu Gln Glu Ser Val  Val Gln Arg Cys Asp  Cys Cys Leu 
    1340                 1345                 1350             


Trp Glu  Ala Ser Leu Glu Asn  Leu Glu Ile Glu Pro  Asp Gly Asn 
    1355                 1360                 1365             


Ile Leu  Gln Leu Asn Gln Thr  Leu Glu Glu Cys Val  Pro Arg Val 
    1370                 1375                 1380             


Arg Ser  Val His His Val Ile  Glu Glu Cys Lys Gln  Glu Asn Gln 
    1385                 1390                 1395             


Tyr Leu  Glu Gly Asn Thr Gln  Leu Leu Glu Lys Val  Lys Ala His 
    1400                 1405                 1410             


Glu Ile  Ala Trp Leu His Gly  Thr Ile Gln Thr His  Gln Glu Arg 
    1415                 1420                 1425             


Pro Arg  Val Gln Asn Gln Val  Ile Leu Glu Glu Asn  Thr Thr Leu 
    1430                 1435                 1440             


Leu Gly  Phe Gln Asp Lys His  Phe Gln His Gln Ala  Thr Ile Ala 
    1445                 1450                 1455             


Glu Leu  Glu Leu Glu Lys Thr  Lys Leu Gln Glu Leu  Thr Arg Lys 
    1460                 1465                 1470             


Leu Lys  Glu Arg Val Thr Ile  Leu Val Lys Gln Lys  Asp Val Leu 
    1475                 1480                 1485             


Ser His  Gly Glu Lys Glu Glu  Glu Leu Lys Ala Met  Met His Asp 
    1490                 1495                 1500             


Leu Gln  Ile Thr Cys Ser Glu  Met Gln Gln Lys Val  Glu Leu Leu 
    1505                 1510                 1515             


Arg Tyr  Glu Ser Glu Lys Leu  Gln Gln Glu Asn Ser  Ile Leu Arg 
    1520                 1525                 1530             


Asn Glu  Ile Thr Thr Leu Asn  Glu Glu Asp Ser Ile  Ser Asn Leu 
    1535                 1540                 1545             


Lys Leu  Gly Thr Leu Asn Gly  Ser Gln Glu Glu Met  Trp Gln Lys 
    1550                 1555                 1560             


Thr Glu  Thr Val Lys Gln Glu  Asn Ala Ala Val Gln  Lys Met Val 
    1565                 1570                 1575             


Glu Asn  Leu Lys Lys Gln Ile  Ser Glu Leu Lys Ile  Lys Asn Gln 
    1580                 1585                 1590             


Gln Leu  Asp Leu Glu Asn Thr  Glu Leu Ser Gln Lys  Asn Ser Gln 
    1595                 1600                 1605             


Asn Gln  Glu Lys Leu Gln Glu  Leu Asn Gln Arg Leu  Thr Glu Met 
    1610                 1615                 1620             


Leu Cys  Gln Lys Glu Lys Glu  Pro Gly Asn Ser Ala  Leu Glu Glu 
    1625                 1630                 1635             


Arg Glu  Gln Glu Lys Phe Asn  Leu Lys Glu Glu Leu  Glu Arg Cys 
    1640                 1645                 1650             


Lys Val  Gln Ser Ser Thr Leu  Val Ser Ser Leu Glu  Ala Glu Leu 
    1655                 1660                 1665             


Ser Glu  Val Lys Ile Gln Thr  His Ile Val Gln Gln  Glu Asn His 
    1670                 1675                 1680             


Leu Leu  Lys Asp Glu Leu Glu  Lys Met Lys Gln Leu  His Arg Cys 
    1685                 1690                 1695             


Pro Asp  Leu Ser Asp Phe Gln  Gln Lys Ile Ser Ser  Val Leu Ser 
    1700                 1705                 1710             


Tyr Asn  Glu Lys Leu Leu Lys  Glu Lys Glu Ala Leu  Ser Glu Glu 
    1715                 1720                 1725             


Leu Asn  Ser Cys Val Asp Lys  Leu Ala Lys Ser Ser  Leu Leu Glu 
    1730                 1735                 1740             


His Arg  Ile Ala Thr Met Lys  Gln Glu Gln Lys Ser  Trp Glu His 
    1745                 1750                 1755             


Gln Ser  Ala Ser Leu Lys Ser  Gln Leu Val Ala Ser  Gln Glu Lys 
    1760                 1765                 1770             


Val Gln  Asn Leu Glu Asp Thr  Val Gln Asn Val Asn  Leu Gln Met 
    1775                 1780                 1785             


Ser Arg  Met Lys Ser Asp Leu  Arg Val Thr Gln Gln  Glu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Gln Glu Val Met  Ser Leu His Lys Gln  Leu Gln Asn 
    1805                 1810                 1815             


Ala Gly  Gly Lys Ser Trp Ala  Pro Glu Ile Ala Thr  His Pro Ser 
    1820                 1825                 1830             


Gly Leu  His Asn Gln Gln Lys  Arg Leu Ser Trp Asp  Lys Leu Asp 
    1835                 1840                 1845             


His Leu  Met Asn Glu Glu Gln  Gln Leu Leu Trp Gln  Glu Asn Glu 
    1850                 1855                 1860             


Arg Leu  Gln Thr Met Val Gln  Asn Thr Lys Ala Glu  Leu Thr His 
    1865                 1870                 1875             


Ser Arg  Glu Lys Val Arg Gln  Leu Glu Ser Asn Leu  Leu Pro Lys 
    1880                 1885                 1890             


His Gln  Lys His Leu Asn Pro  Ser Gly Thr Met Asn  Pro Thr Glu 
    1895                 1900                 1905             


Gln Glu  Lys Leu Ser Leu Lys  Arg Glu Cys Asp Gln  Phe Gln Lys 
    1910                 1915                 1920             


Glu Gln  Ser Pro Ala Asn Arg  Lys Val Ser Gln Met  Asn Ser Leu 
    1925                 1930                 1935             


Glu Gln  Glu Leu Glu Thr Ile  His Leu Glu Asn Glu  Gly Leu Lys 
    1940                 1945                 1950             


Lys Lys  Gln Val Lys Leu Asp  Glu Gln Leu Met Glu  Met Gln His 
    1955                 1960                 1965             


Leu Arg  Ser Thr Ala Thr Pro  Ser Pro Ser Pro His  Ala Trp Asp 
    1970                 1975                 1980             


Leu Gln  Leu Leu Gln Gln Gln  Ala Cys Pro Met Val  Pro Arg Glu 
    1985                 1990                 1995             


Gln Phe  Leu Gln Leu Gln Arg  Gln Leu Leu Gln Ala  Glu Arg Ile 
    2000                 2005                 2010             


Asn Gln  His Leu Gln Glu Glu  Leu Glu Asn Arg Thr  Ser Glu Thr 
    2015                 2020                 2025             


Asn Thr  Pro Gln Gly Asn Gln  Glu Gln Leu Val Thr  Val Met Glu 
    2030                 2035                 2040             


Glu Arg  Met Ile Glu Val Glu  Gln Lys Leu Lys Leu  Val Lys Arg 
    2045                 2050                 2055             


Leu Leu  Gln Glu Lys Val Asn  Gln Leu Lys Glu Gln  Val Ser Leu 
    2060                 2065                 2070             


Pro Gly  His Leu Cys Ser Pro  Thr Ser His Ser Ser  Phe Asn Ser 
    2075                 2080                 2085             


Ser Phe  Thr Ser Leu Tyr Cys  His 
    2090                 2095     


<210> 5470
<211> 391
<212> PRT
<213> Homo sapiens

<400> 5470
Met Ala Ala Leu Thr Thr Leu Phe Lys Tyr Ile Asp Glu Asn Gln Asp 
1               5                   10                  15      


Arg Tyr Ile Lys Lys Leu Ala Lys Trp Val Ala Ile Gln Ser Val Ser 
            20                  25                  30          


Ala Trp Pro Glu Lys Arg Gly Glu Ile Arg Arg Met Met Glu Val Ala 
        35                  40                  45              


Ala Ala Asp Val Lys Gln Leu Gly Gly Ser Val Glu Leu Val Asp Ile 
    50                  55                  60                  


Gly Lys Gln Lys Glu Ile Pro Val Asn Val Arg Phe Cys Leu Glu Gly 
65                  70                  75                  80  


Met Glu Glu Ser Gly Ser Glu Gly Leu Asp Glu Leu Ile Phe Ala Arg 
                85                  90                  95      


Lys Asp Thr Phe Phe Lys Asp Val Asp Tyr Val Cys Ile Ser Asp Asn 
            100                 105                 110         


Tyr Trp Leu Gly Lys Lys Lys Pro Cys Ile Thr Tyr Gly Leu Arg Gly 
        115                 120                 125             


Ile Cys Tyr Phe Phe Ile Glu Val Glu Cys Ser Asn Lys Asp Leu His 
    130                 135                 140                 


Ser Gly Val Tyr Gly Gly Ser Val His Glu Ala Met Thr Asp Leu Ile 
145                 150                 155                 160 


Leu Leu Met Gly Ser Leu Val Asp Lys Arg Gly Asn Ile Leu Ile Pro 
                165                 170                 175     


Gly Ile Asn Glu Ala Val Ala Ala Val Thr Glu Glu Glu His Lys Leu 
            180                 185                 190         


Tyr Asp Asp Ile Asp Phe Asp Ile Glu Glu Phe Ala Lys Asp Val Gly 
        195                 200                 205             


Ala Gln Ile Leu Leu His Ser His Lys Lys Asp Ile Leu Met His Arg 
    210                 215                 220                 


Trp Arg Tyr Pro Ser Leu Ser Leu His Gly Ile Glu Gly Ala Phe Ser 
225                 230                 235                 240 


Gly Ser Gly Ala Lys Thr Val Ile Pro Arg Lys Val Val Gly Lys Phe 
                245                 250                 255     


Ser Ile Arg Leu Val Pro Asn Met Thr Pro Glu Val Val Gly Glu Gln 
            260                 265                 270         


Val Thr Ser Tyr Leu Thr Lys Lys Phe Ala Glu Leu Arg Ser Pro Asn 
        275                 280                 285             


Glu Phe Lys Val Tyr Met Gly His Gly Gly Lys Pro Trp Val Ser Asp 
    290                 295                 300                 


Phe Ser His Pro His Tyr Leu Ala Gly Arg Arg Ala Met Lys Thr Val 
305                 310                 315                 320 


Phe Gly Val Glu Pro Asp Leu Thr Arg Glu Gly Gly Ser Ile Pro Val 
                325                 330                 335     


Thr Leu Thr Phe Gln Glu Ala Thr Gly Lys Asn Val Met Leu Leu Pro 
            340                 345                 350         


Val Gly Ser Ala Asp Asp Gly Ala His Ser Gln Asn Glu Lys Leu Asn 
        355                 360                 365             


Arg Tyr Asn Tyr Ile Glu Gly Thr Lys Met Leu Ala Ala Tyr Leu Tyr 
    370                 375                 380                 


Glu Val Ser Gln Leu Lys Asp 
385                 390     


<210> 5471
<211> 1989
<212> PRT
<213> Homo sapiens

<400> 5471
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu 
            100                 105                 110         


Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser 
    130                 135                 140                 


Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln 
145                 150                 155                 160 


Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser 
                165                 170                 175     


Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu 
            180                 185                 190         


Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val 
        195                 200                 205             


Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu 
    210                 215                 220                 


Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu 
225                 230                 235                 240 


Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser 
                245                 250                 255     


Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser 
            260                 265                 270         


Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser 
        275                 280                 285             


Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His 
    290                 295                 300                 


Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu 
305                 310                 315                 320 


Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn 
                325                 330                 335     


Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val 
            340                 345                 350         


Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu 
        355                 360                 365             


Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu 
    370                 375                 380                 


Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met 
385                 390                 395                 400 


Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu 
                405                 410                 415     


Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala 
            420                 425                 430         


Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala 
        435                 440                 445             


Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr 
    450                 455                 460                 


Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn 
465                 470                 475                 480 


Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Lys Leu Ala Glu 
                485                 490                 495     


Tyr Glu Asn Leu Thr Asn Lys Leu Gln Arg Asn Leu Glu Asn Val Leu 
            500                 505                 510         


Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu 
        515                 520                 525             


Gln Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys 
    530                 535                 540                 


Arg Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu 
545                 550                 555                 560 


Tyr Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro 
                565                 570                 575     


Ser Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly 
            580                 585                 590         


Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu 
        595                 600                 605             


Leu Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys 
    610                 615                 620                 


Leu Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu 
625                 630                 635                 640 


Asp Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln 
                645                 650                 655     


Arg His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu 
            660                 665                 670         


Lys Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu 
        675                 680                 685             


Ala His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu 
    690                 695                 700                 


Gln Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg 
705                 710                 715                 720 


Leu Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala 
                725                 730                 735     


Ser Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu 
            740                 745                 750         


Glu Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu 
        755                 760                 765             


Gln Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu 
    770                 775                 780                 


Arg Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg 
785                 790                 795                 800 


Glu Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala 
                805                 810                 815     


Gln Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala 
            820                 825                 830         


Leu Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln 
        835                 840                 845             


Glu Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu 
    850                 855                 860                 


Leu Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu 
865                 870                 875                 880 


Lys Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met 
                885                 890                 895     


Leu Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg 
            900                 905                 910         


Gln Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr 
        915                 920                 925             


Gln Gln Ser Leu Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His 
    930                 935                 940                 


Lys Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala 
945                 950                 955                 960 


Ser Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His 
                965                 970                 975     


Asp Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn 
            980                 985                 990         


Ile His Lys Ala Thr Cys Glu Thr  Ala Asp Arg Glu Arg  Ala Glu Met 
        995                 1000                 1005             


Ser Thr  Glu Ile Ser Arg Leu  Gln Ser Lys Ile Lys  Glu Met Gln 
    1010                 1015                 1020             


Gln Ala  Thr Ser Pro Leu Ser  Met Leu Gln Ser Gly  Cys Gln Val 
    1025                 1030                 1035             


Ile Gly  Glu Glu Glu Val Glu  Gly Asp Gly Ala Leu  Ser Leu Leu 
    1040                 1045                 1050             


Gln Gln  Gly Glu Gln Leu Leu  Glu Glu Asn Gly Asp  Val Leu Leu 
    1055                 1060                 1065             


Ser Leu  Gln Arg Ala His Glu  Gln Ala Val Lys Glu  Asn Val Lys 
    1070                 1075                 1080             


Met Ala  Thr Glu Ile Ser Arg  Leu Gln Gln Arg Leu  Gln Lys Leu 
    1085                 1090                 1095             


Glu Pro  Gly Leu Val Met Ser  Ser Cys Leu Asp Glu  Pro Ala Thr 
    1100                 1105                 1110             


Glu Phe  Phe Gly Asn Thr Ala  Glu Gln Thr Glu Gln  Phe Leu Gln 
    1115                 1120                 1125             


Gln Asn  Arg Thr Lys Gln Val  Glu Gly Val Thr Arg  Arg His Val 
    1130                 1135                 1140             


Leu Ser  Asp Leu Glu Asp Asp  Glu Val Arg Asp Leu  Gly Ser Thr 
    1145                 1150                 1155             


Gly Thr  Ser Ser Val Gln Arg  Gln Glu Val Lys Ile  Glu Glu Ser 
    1160                 1165                 1170             


Glu Ala  Ser Val Glu Gly Phe  Ser Glu Leu Glu Asn  Ser Glu Glu 
    1175                 1180                 1185             


Thr Arg  Thr Glu Ser Trp Glu  Leu Lys Asn Gln Ile  Ser Gln Leu 
    1190                 1195                 1200             


Gln Glu  Gln Leu Met Met Leu  Cys Ala Asp Cys Asp  Arg Ala Ser 
    1205                 1210                 1215             


Glu Lys  Lys Gln Asp Leu Leu  Phe Asp Val Ser Val  Leu Lys Lys 
    1220                 1225                 1230             


Lys Leu  Lys Met Leu Glu Arg  Ile Pro Glu Ala Ser  Pro Lys Tyr 
    1235                 1240                 1245             


Lys Leu  Leu Tyr Glu Asp Val  Ser Arg Glu Asn Asp  Cys Leu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Arg Met Met Glu  Thr Arg Tyr Asp Glu  Ala Leu Glu 
    1265                 1270                 1275             


Asn Asn  Lys Glu Leu Thr Ala  Glu Val Phe Arg Leu  Gln Asp Glu 
    1280                 1285                 1290             


Leu Lys  Lys Met Glu Glu Val  Thr Glu Thr Phe Leu  Ser Leu Glu 
    1295                 1300                 1305             


Lys Ser  Tyr Asp Glu Val Lys  Ile Glu Asn Glu Gly  Leu Asn Val 
    1310                 1315                 1320             


Leu Val  Leu Arg Leu Gln Gly  Lys Ile Glu Lys Leu  Gln Glu Ser 
    1325                 1330                 1335             


Val Val  Gln Arg Cys Asp Cys  Cys Leu Trp Glu Ala  Ser Leu Glu 
    1340                 1345                 1350             


Asn Leu  Glu Ile Glu Pro Asp  Gly Asn Ile Leu Gln  Leu Asn Gln 
    1355                 1360                 1365             


Thr Leu  Glu Glu Cys Val Pro  Arg Val Arg Ser Val  His His Val 
    1370                 1375                 1380             


Ile Glu  Glu Cys Lys Gln Glu  Asn Gln Tyr Leu Glu  Gly Asn Thr 
    1385                 1390                 1395             


Gln Leu  Leu Glu Lys Val Lys  Ala His Glu Ile Ala  Trp Leu His 
    1400                 1405                 1410             


Gly Thr  Ile Gln Thr His Gln  Glu Arg Pro Arg Val  Gln Asn Gln 
    1415                 1420                 1425             


Val Ile  Leu Glu Glu Asn Thr  Thr Leu Leu Gly Phe  Gln Asp Lys 
    1430                 1435                 1440             


His Phe  Gln His Gln Ala Thr  Ile Ala Glu Leu Glu  Leu Glu Lys 
    1445                 1450                 1455             


Thr Lys  Leu Gln Glu Leu Thr  Arg Lys Leu Lys Glu  Arg Val Thr 
    1460                 1465                 1470             


Ile Leu  Val Lys Gln Lys Asp  Val Leu Ser His Gly  Glu Lys Glu 
    1475                 1480                 1485             


Glu Glu  Leu Lys Ala Met Met  His Asp Leu Gln Ile  Thr Cys Ser 
    1490                 1495                 1500             


Glu Met  Gln Gln Lys Val Glu  Leu Leu Arg Tyr Glu  Ser Glu Lys 
    1505                 1510                 1515             


Leu Gln  Gln Glu Asn Ser Ile  Leu Arg Asn Glu Ile  Thr Thr Leu 
    1520                 1525                 1530             


Asn Glu  Glu Asp Ser Ile Ser  Asn Leu Lys Leu Gly  Thr Leu Asn 
    1535                 1540                 1545             


Gly Ser  Gln Glu Glu Met Trp  Gln Lys Thr Glu Thr  Val Lys Gln 
    1550                 1555                 1560             


Glu Asn  Ala Ala Val Gln Lys  Met Val Glu Asn Leu  Lys Lys Gln 
    1565                 1570                 1575             


Ile Ser  Glu Leu Lys Ile Lys  Asn Gln Gln Leu Asp  Leu Glu Asn 
    1580                 1585                 1590             


Thr Glu  Leu Ser Gln Lys Asn  Ser Gln Asn Gln Glu  Lys Leu Gln 
    1595                 1600                 1605             


Glu Leu  Asn Gln Arg Leu Thr  Glu Met Leu Cys Gln  Lys Glu Lys 
    1610                 1615                 1620             


Glu Pro  Gly Asn Ser Ala Leu  Glu Glu Arg Glu Gln  Glu Lys Phe 
    1625                 1630                 1635             


Asn Leu  Lys Glu Glu Leu Glu  Arg Cys Lys Val Gln  Ser Ser Thr 
    1640                 1645                 1650             


Leu Val  Ser Ser Leu Glu Ala  Glu Leu Ser Glu Val  Lys Ile Gln 
    1655                 1660                 1665             


Thr His  Ile Val Gln Gln Glu  Asn His Leu Leu Lys  Asp Glu Leu 
    1670                 1675                 1680             


Glu Lys  Met Lys Gln Leu His  Arg Cys Pro Asp Leu  Ser Asp Phe 
    1685                 1690                 1695             


Gln Gln  Lys Ile Ser Ser Val  Leu Ser Tyr Asn Glu  Lys Leu Leu 
    1700                 1705                 1710             


Lys Glu  Lys Glu Ala Leu Ser  Glu Glu Leu Asn Ser  Cys Val Asp 
    1715                 1720                 1725             


Lys Leu  Ala Lys Ser Ser Leu  Leu Glu His Arg Ile  Ala Thr Met 
    1730                 1735                 1740             


Lys Gln  Glu Gln Lys Ser Trp  Glu His Gln Ser Ala  Ser Leu Lys 
    1745                 1750                 1755             


Ser Gln  Leu Val Ala Ser Gln  Glu Lys Val Gln Asn  Leu Glu Asp 
    1760                 1765                 1770             


Thr Val  Gln Asn Val Asn Leu  Gln Met Ser Arg Met  Lys Ser Asp 
    1775                 1780                 1785             


Leu Arg  Val Thr Gln Gln Glu  Lys Glu Ala Leu Lys  Gln Glu Val 
    1790                 1795                 1800             


Met Ser  Leu His Lys Gln Leu  Gln Asn Ala Gly Gly  Lys Ser Trp 
    1805                 1810                 1815             


Ala Pro  Glu Ile Ala Thr His  Pro Ser Gly Leu His  Asn Gln Gln 
    1820                 1825                 1830             


Lys Arg  Leu Ser Trp Asp Lys  Leu Asp His Leu Met  Asn Glu Glu 
    1835                 1840                 1845             


Gln Gln  Leu Leu Trp Gln Glu  Asn Glu Arg Leu Gln  Thr Met Val 
    1850                 1855                 1860             


Gln Asn  Thr Lys Ala Glu Leu  Thr His Ser Arg Glu  Lys Val Arg 
    1865                 1870                 1875             


Gln Leu  Glu Ser Asn Leu Leu  Pro Lys His Gln Lys  His Leu Asn 
    1880                 1885                 1890             


Pro Ser  Gly Thr Met Asn Pro  Thr Glu Gln Glu Lys  Leu Ser Leu 
    1895                 1900                 1905             


Lys Arg  Glu Cys Asp Gln Phe  Gln Lys Glu Gln Ser  Pro Ala Asn 
    1910                 1915                 1920             


Arg Lys  Val Ser Gln Met Asn  Ser Leu Glu Gln Glu  Leu Glu Thr 
    1925                 1930                 1935             


Ile His  Leu Glu Asn Glu Gly  Leu Lys Lys Lys Gln  Val Lys Leu 
    1940                 1945                 1950             


Asp Glu  Gln Leu Met Glu Asn  Ser Val Val Gly Ser  Ser Arg Glu 
    1955                 1960                 1965             


Gly Cys  Ser Ser Leu Pro Glu  Ile Val Cys Glu Asp  Ala Ala Pro 
    1970                 1975                 1980             


Glu Val  His Cys Asp Ala 
    1985                 


<210> 5472
<211> 304
<212> PRT
<213> Homo sapiens

<400> 5472
Met Gly Gln Cys Val Thr Lys Cys Lys Asn Pro Ser Ser Thr Leu Gly 
1               5                   10                  15      


Ser Lys Asn Gly Asp Arg Glu Pro Ser Asn Lys Ser His Ser Arg Arg 
            20                  25                  30          


Gly Ala Gly His Arg Glu Glu Gln Val Pro Pro Cys Gly Lys Pro Gly 
        35                  40                  45              


Gly Asp Ile Leu Val Asn Gly Thr Lys Lys Ala Glu Ala Ala Thr Glu 
    50                  55                  60                  


Ala Cys Gln Leu Pro Thr Ser Ser Gly Asp Ala Gly Arg Glu Ser Lys 
65                  70                  75                  80  


Ser Asn Ala Glu Glu Ser Ser Leu Gln Arg Leu Glu Glu Leu Phe Arg 
                85                  90                  95      


Arg Tyr Lys Asp Glu Arg Glu Asp Ala Ile Leu Glu Glu Gly Met Glu 
            100                 105                 110         


Arg Phe Cys Asn Asp Leu Cys Val Asp Pro Thr Glu Phe Arg Val Leu 
        115                 120                 125             


Leu Leu Ala Trp Lys Phe Gln Ala Ala Thr Met Cys Lys Phe Thr Arg 
    130                 135                 140                 


Lys Glu Phe Phe Asp Gly Cys Lys Ala Ile Ser Ala Asp Ser Ile Asp 
145                 150                 155                 160 


Gly Ile Cys Ala Arg Phe Pro Ser Leu Leu Thr Glu Ala Lys Gln Glu 
                165                 170                 175     


Asp Lys Phe Lys Asp Leu Tyr Arg Phe Thr Phe Gln Phe Gly Leu Asp 
            180                 185                 190         


Ser Glu Glu Gly Gln Arg Ser Leu His Arg Glu Ile Ala Ile Ala Leu 
        195                 200                 205             


Trp Lys Leu Val Phe Thr Gln Asn Asn Pro Pro Val Leu Asp Gln Trp 
    210                 215                 220                 


Leu Asn Phe Leu Thr Glu Asn Pro Ser Gly Ile Lys Gly Ile Ser Arg 
225                 230                 235                 240 


Asp Thr Trp Asn Met Phe Leu Asn Phe Thr Gln Val Ile Gly Pro Asp 
                245                 250                 255     


Leu Ser Asn Tyr Ser Glu Asp Glu Ala Trp Pro Ser Leu Phe Asp Thr 
            260                 265                 270         


Phe Val Glu Trp Glu Met Glu Arg Arg Lys Arg Glu Gly Glu Gly Arg 
        275                 280                 285             


Gly Ala Leu Ser Ser Gly Pro Glu Gly Leu Cys Pro Glu Glu Gln Thr 
    290                 295                 300                 


<210> 5473
<211> 637
<212> PRT
<213> Homo sapiens

<400> 5473
Met Ala Ala Met Ala Val Gly Gly Ala Gly Gly Ser Arg Val Ser Ser 
1               5                   10                  15      


Gly Arg Asp Leu Asn Cys Val Pro Glu Ile Ala Asp Thr Leu Gly Ala 
            20                  25                  30          


Val Ala Lys Gln Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro 
        35                  40                  45              


Arg Phe Lys Arg Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly 
    50                  55                  60                  


Pro Gln Thr Arg Ser Asp Leu Leu Leu Ser Gly Arg Asp Trp Asn Thr 
65                  70                  75                  80  


Leu Ile Val Gly Lys Leu Ser Pro Trp Ile Arg Pro Asp Ser Lys Val 
                85                  90                  95      


Glu Lys Ile Arg Arg Asn Ser Glu Ala Ala Met Leu Gln Glu Leu Asn 
            100                 105                 110         


Phe Gly Ala Tyr Leu Gly Leu Pro Ala Phe Leu Leu Pro Leu Asn Gln 
        115                 120                 125             


Glu Asp Asn Thr Asn Leu Ala Arg Val Leu Thr Asn His Ile His Thr 
    130                 135                 140                 


Gly His His Ser Ser Met Phe Trp Met Arg Val Pro Leu Val Ala Pro 
145                 150                 155                 160 


Glu Asp Leu Arg Asp Asp Ile Ile Glu Asn Ala Pro Thr Thr His Thr 
                165                 170                 175     


Glu Glu Tyr Ser Gly Glu Glu Lys Thr Trp Met Trp Trp His Asn Phe 
            180                 185                 190         


Arg Thr Leu Cys Asp Tyr Ser Lys Arg Ile Ala Val Ala Leu Glu Ile 
        195                 200                 205             


Gly Ala Asp Leu Pro Ser Asn His Val Ile Asp Arg Trp Leu Gly Glu 
    210                 215                 220                 


Pro Ile Lys Ala Ala Ile Leu Pro Thr Ser Ile Phe Leu Thr Asn Lys 
225                 230                 235                 240 


Lys Gly Phe Pro Val Leu Ser Lys Met His Gln Arg Leu Ile Phe Arg 
                245                 250                 255     


Leu Leu Lys Leu Glu Val Gln Phe Ile Ile Thr Gly Thr Asn His His 
            260                 265                 270         


Ser Glu Lys Glu Phe Cys Ser Tyr Leu Gln Tyr Leu Glu Tyr Leu Ser 
        275                 280                 285             


Gln Asn Arg Pro Pro Pro Asn Ala Tyr Glu Leu Phe Ala Lys Gly Tyr 
    290                 295                 300                 


Glu Asp Tyr Leu Gln Ser Pro Leu Gln Pro Leu Met Asp Asn Leu Glu 
305                 310                 315                 320 


Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro Ile Lys Tyr Ser Gln 
                325                 330                 335     


Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp Arg Val Pro Glu Glu 
            340                 345                 350         


Glu Lys Asp Thr Asn Val Gln Val Leu Met Val Leu Gly Ala Gly Arg 
        355                 360                 365             


Gly Pro Leu Val Asn Ala Ser Leu Arg Ala Ala Lys Gln Ala Asp Arg 
    370                 375                 380                 


Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro Asn Ala Val Val Thr 
385                 390                 395                 400 


Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser Gln Val Thr Val Val 
                405                 410                 415     


Ser Ser Asp Met Arg Glu Trp Val Ala Pro Glu Lys Ala Asp Ile Ile 
            420                 425                 430         


Val Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn Glu Leu Ser Pro Glu 
        435                 440                 445             


Cys Leu Asp Gly Ala Gln His Phe Leu Lys Asp Asp Gly Val Ser Ile 
    450                 455                 460                 


Pro Gly Glu Tyr Thr Ser Phe Leu Ala Pro Ile Ser Ser Ser Lys Leu 
465                 470                 475                 480 


Tyr Asn Glu Val Arg Ala Cys Arg Glu Lys Asp Arg Asp Pro Glu Ala 
                485                 490                 495     


Gln Phe Glu Met Pro Tyr Val Val Arg Leu His Asn Phe His Gln Leu 
            500                 505                 510         


Ser Ala Pro Gln Pro Cys Phe Thr Phe Ser His Pro Asn Arg Asp Pro 
        515                 520                 525             


Met Ile Asp Asn Asn Arg Tyr Cys Thr Leu Glu Phe Pro Val Glu Val 
    530                 535                 540                 


Asn Thr Val Leu His Gly Phe Ala Gly Tyr Phe Glu Thr Val Leu Tyr 
545                 550                 555                 560 


Gln Asp Ile Thr Leu Ser Ile Arg Pro Glu Thr His Ser Pro Gly Met 
                565                 570                 575     


Phe Ser Trp Phe Pro Ile Leu Phe Pro Ile Lys Gln Pro Ile Thr Val 
            580                 585                 590         


Arg Glu Gly Gln Thr Ile Cys Val Arg Phe Trp Arg Cys Ser Asn Ser 
        595                 600                 605             


Lys Lys Val Trp Tyr Glu Trp Ala Val Thr Ala Pro Val Cys Ser Ala 
    610                 615                 620                 


Ile His Asn Pro Thr Gly Arg Ser Tyr Thr Ile Gly Leu 
625                 630                 635         


<210> 5474
<211> 346
<212> PRT
<213> Homo sapiens

<400> 5474
Met Ala Pro Gly Ser Val Thr Ser Asp Ile Ser Pro Ser Ser Thr Ser 
1               5                   10                  15      


Thr Ala Gly Ser Ser Arg Ser Pro Glu Ser Glu Lys Pro Gly Pro Ser 
            20                  25                  30          


His Gly Gly Val Pro Pro Gly Gly Pro Ser His Ser Ser Leu Pro Val 
        35                  40                  45              


Gly Arg Arg His Pro Pro Val Leu Arg Met Val Leu Glu Ala Leu Gln 
    50                  55                  60                  


Ala Gly Glu Gln Arg Arg Gly Thr Ser Val Ala Ala Ile Lys Leu Tyr 
65                  70                  75                  80  


Ile Leu His Lys Tyr Pro Thr Val Asp Val Leu Arg Phe Lys Tyr Leu 
                85                  90                  95      


Leu Lys Gln Ala Leu Ala Thr Gly Met Arg Arg Gly Leu Leu Ala Arg 
            100                 105                 110         


Pro Leu Asn Ser Lys Ala Arg Gly Ala Thr Gly Ser Phe Lys Leu Val 
        115                 120                 125             


Pro Lys His Lys Lys Lys Ile Gln Pro Arg Lys Met Ala Pro Ala Thr 
    130                 135                 140                 


Ala Pro Arg Arg Ala Gly Glu Ala Lys Gly Lys Gly Pro Lys Lys Pro 
145                 150                 155                 160 


Ser Glu Ala Lys Glu Asp Pro Pro Asn Val Gly Lys Val Lys Lys Ala 
                165                 170                 175     


Ala Lys Arg Pro Ala Lys Val Gln Lys Pro Pro Pro Lys Pro Gly Ala 
            180                 185                 190         


Ala Thr Glu Lys Ala Arg Lys Gln Gly Gly Ala Ala Lys Asp Thr Arg 
        195                 200                 205             


Ala Gln Ser Gly Glu Ala Arg Lys Val Pro Pro Lys Pro Asp Lys Ala 
    210                 215                 220                 


Met Arg Ala Pro Ser Ser Ala Gly Gly Leu Ser Arg Lys Ala Lys Ala 
225                 230                 235                 240 


Lys Gly Ser Arg Ser Ser Gln Gly Asp Ala Glu Ala Tyr Arg Lys Thr 
                245                 250                 255     


Lys Ala Glu Ser Lys Ser Ser Lys Pro Thr Ala Ser Lys Val Lys Asn 
            260                 265                 270         


Gly Ala Ala Ser Pro Thr Lys Lys Lys Val Val Ala Lys Ala Lys Ala 
        275                 280                 285             


Pro Lys Ala Gly Gln Gly Pro Asn Thr Lys Ala Ala Ala Pro Ala Lys 
    290                 295                 300                 


Gly Ser Gly Ser Lys Val Val Pro Ala His Leu Ser Arg Lys Thr Glu 
305                 310                 315                 320 


Ala Pro Lys Gly Pro Arg Lys Ala Gly Leu Pro Ile Lys Ala Ser Ser 
                325                 330                 335     


Ser Lys Val Ser Ser Gln Arg Ala Glu Ala 
            340                 345     


<210> 5475
<211> 622
<212> PRT
<213> Homo sapiens

<400> 5475
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 
            100                 105                 110         


Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 
        115                 120                 125             


Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 
    130                 135                 140                 


Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 
145                 150                 155                 160 


Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 
                165                 170                 175     


Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 
            180                 185                 190         


Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 
        195                 200                 205             


Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 
    210                 215                 220                 


Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 
225                 230                 235                 240 


His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 
                245                 250                 255     


Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 
            260                 265                 270         


Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 
        275                 280                 285             


Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 
    290                 295                 300                 


Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 
305                 310                 315                 320 


Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 
                325                 330                 335     


Gly Met Thr Ser Val Leu Met Ser Ala Ile Gly Leu Pro Val Cys Leu 
            340                 345                 350         


Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro Ala Ser Arg Leu Ala Ser 
        355                 360                 365             


Lys Ser His Gly Ser Val Lys Arg Leu Arg Lys Met Ser Val Lys Gly 
    370                 375                 380                 


Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn Tyr 
385                 390                 395                 400 


Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys Met 
                405                 410                 415     


Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser Lys 
            420                 425                 430         


Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His Ala 
        435                 440                 445             


Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys Asp 
    450                 455                 460                 


Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys Thr 
465                 470                 475                 480 


Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met Ser 
                485                 490                 495     


Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser Ile 
            500                 505                 510         


Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro Phe 
        515                 520                 525             


Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala Gln 
    530                 535                 540                 


Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg Leu 
545                 550                 555                 560 


Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr Val 
                565                 570                 575     


Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile Thr 
            580                 585                 590         


Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala Glu 
        595                 600                 605             


Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 
    610                 615                 620         


<210> 5476
<211> 261
<212> PRT
<213> Homo sapiens

<400> 5476
Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp 
            180                 185                 190         


Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro 
        195                 200                 205             


Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp 
    210                 215                 220                 


Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys 
225                 230                 235                 240 


Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile 
                245                 250                 255     


Ser Leu Asp Gln Gln 
            260     


<210> 5477
<211> 660
<212> PRT
<213> Homo sapiens

<400> 5477
Leu Ser Leu Pro Ser Val Thr Tyr Leu Leu Leu Glu Val Ile Pro Asp 
1               5                   10                  15      


Ser Met Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly 
            20                  25                  30          


His Gly Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu 
        35                  40                  45              


Leu Ala Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp 
    50                  55                  60                  


Arg Thr Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile 
65                  70                  75                  80  


Gln Arg His Arg Lys Ala Leu Leu Ser Lys Val Glu Ala Thr Arg Gly 
                85                  90                  95      


Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe Leu Pro 
            100                 105                 110         


Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile Gly Val 
        115                 120                 125             


Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg Leu Trp 
    130                 135                 140                 


Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro Leu Thr 
145                 150                 155                 160 


Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg Leu Ile 
                165                 170                 175     


Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val Ala Val 
            180                 185                 190         


Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys Arg Thr 
        195                 200                 205             


Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys Lys Glu 
    210                 215                 220                 


Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn Leu Phe 
225                 230                 235                 240 


Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser Gly Gln 
                245                 250                 255     


Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly Phe Asn 
            260                 265                 270         


Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu Asp Gln 
        275                 280                 285             


Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg Ala Leu 
    290                 295                 300                 


Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly Met Ala 
305                 310                 315                 320 


Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala Glu Leu 
                325                 330                 335     


Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe Arg Met 
            340                 345                 350         


Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro Arg Ile 
        355                 360                 365             


Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu Gly Arg 
    370                 375                 380                 


Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr Glu Gln 
385                 390                 395                 400 


Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly Ala Pro 
                405                 410                 415     


Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser Val Ala 
            420                 425                 430         


Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala Ala Tyr 
        435                 440                 445             


Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr Glu Ser 
    450                 455                 460                 


Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg Ser Ala 
465                 470                 475                 480 


Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val Phe Leu 
                485                 490                 495     


Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu Leu Ala 
            500                 505                 510         


Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr Gln Val 
        515                 520                 525             


Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val Cys Ala 
    530                 535                 540                 


Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His Thr Glu 
545                 550                 555                 560 


Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu Ala Arg 
                565                 570                 575     


Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu Gln Val 
            580                 585                 590         


Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu Ser Gln 
        595                 600                 605             


Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg Lys Leu 
    610                 615                 620                 


Arg Trp Ile Pro Gly Gln Gly Ala Gly Ala Gly Glu Gly Ala Glu Glu 
625                 630                 635                 640 


Arg Ala Glu Ala Val Pro Ser Pro Pro Pro Ser Phe Ser Val Ser Leu 
                645                 650                 655     


Leu Gly Leu Pro 
            660 


<210> 5478
<211> 383
<212> PRT
<213> Homo sapiens

<400> 5478
Met Leu Ser Arg Lys Lys Thr Lys Asn Glu Val Ser Lys Pro Ala Glu 
1               5                   10                  15      


Val Gln Gly Lys Tyr Val Lys Lys Glu Thr Ser Pro Leu Leu Arg Asn 
            20                  25                  30          


Leu Met Pro Ser Phe Ile Arg His Gly Pro Thr Ile Pro Arg Arg Thr 
        35                  40                  45              


Asp Ile Cys Leu Pro Asp Ser Ser Pro Asn Ala Phe Ser Thr Ser Gly 
    50                  55                  60                  


Asp Val Val Ser Arg Asn Gln Ser Phe Leu Arg Thr Pro Ile Gln Arg 
65                  70                  75                  80  


Thr Pro His Glu Ile Met Arg Arg Glu Ser Asn Arg Leu Ser Ala Pro 
                85                  90                  95      


Ser Tyr Leu Ala Arg Ser Leu Ala Asp Val Pro Arg Glu Tyr Gly Ser 
            100                 105                 110         


Ser Gln Ser Phe Val Thr Glu Val Ser Phe Ala Val Glu Asn Gly Asp 
        115                 120                 125             


Ser Gly Ser Arg Tyr Tyr Tyr Ser Asp Asn Phe Phe Asp Gly Gln Arg 
    130                 135                 140                 


Lys Arg Pro Leu Gly Asp Arg Ala His Glu Asp Tyr Arg Tyr Tyr Glu 
145                 150                 155                 160 


Tyr Asn His Asp Leu Phe Gln Arg Met Pro Gln Asn Gln Gly Arg His 
                165                 170                 175     


Ala Ser Gly Ile Gly Arg Val Ala Ala Thr Ser Leu Gly Asn Leu Thr 
            180                 185                 190         


Asn His Gly Ser Glu Asp Leu Pro Leu Pro Pro Gly Trp Ser Val Asp 
        195                 200                 205             


Trp Thr Met Arg Gly Arg Lys Tyr Tyr Ile Asp His Asn Thr Asn Thr 
    210                 215                 220                 


Thr His Trp Ser His Pro Leu Glu Arg Glu Gly Leu Pro Pro Gly Trp 
225                 230                 235                 240 


Glu Arg Val Glu Ser Ser Glu Phe Gly Thr Tyr Tyr Val Asp His Thr 
                245                 250                 255     


Asn Lys Lys Ala Gln Tyr Arg His Pro Cys Ala Pro Ser Val Pro Arg 
            260                 265                 270         


Tyr Asp Gln Pro Pro Pro Val Thr Tyr Gln Pro Gln Gln Thr Glu Arg 
        275                 280                 285             


Asn Gln Ser Leu Leu Val Pro Ala Asn Pro Tyr His Thr Ala Glu Ile 
    290                 295                 300                 


Pro Asp Trp Leu Gln Val Tyr Ala Arg Ala Pro Val Lys Tyr Asp His 
305                 310                 315                 320 


Ile Leu Lys Trp Glu Leu Phe Gln Leu Ala Asp Leu Asp Thr Tyr Gln 
                325                 330                 335     


Gly Met Leu Lys Leu Leu Phe Met Lys Glu Leu Glu Gln Ile Val Lys 
            340                 345                 350         


Met Tyr Glu Ala Tyr Arg Gln Ala Leu Leu Thr Glu Leu Glu Asn Arg 
        355                 360                 365             


Lys Gln Arg Gln Gln Trp Tyr Ala Gln Gln His Gly Lys Asn Phe 
    370                 375                 380             


<210> 5479
<211> 791
<212> PRT
<213> Homo sapiens

<400> 5479
Met Ser Asn Gln Gln Glu Lys Tyr Glu Ala Gln Asn Ile Val Asn Ser 
1               5                   10                  15      


Thr Glu Glu Ser Asp Asp Ala Phe Asp Thr Val Thr Ile Pro Val Pro 
            20                  25                  30          


Ser Glu Glu Pro Gln Glu Ser Asp Gln Thr Glu Glu His Glu Ser Gly 
        35                  40                  45              


Ile Glu Gln Phe Ser Glu Ser His Ala Ile His Val Glu Glu Gln Ser 
    50                  55                  60                  


Asp Gln Ser Phe Ser Ser Leu Glu Pro Asp Asn Glu Gln Leu Met Glu 
65                  70                  75                  80  


Glu Val Ile Ser Pro Arg Gln Val Ser Tyr Thr Pro Gln His His Glu 
                85                  90                  95      


Lys Gln Tyr Ala Met Gln Arg Pro Asn Asp Asp Ser Leu Ala Phe Leu 
            100                 105                 110         


Asp Lys Ile Lys Ser Val Lys Glu Ser Leu Gln Glu Ser Val Glu Asp 
        115                 120                 125             


Ser Leu Ala Thr Val Lys Val Val Leu Ile Pro Val Gly Gln Glu Ile 
    130                 135                 140                 


Val Ile Pro Phe Lys Val Asp Thr Ile Leu Lys Tyr Leu Lys Asp His 
145                 150                 155                 160 


Phe Ser His Leu Leu Gly Ile Pro His Ser Val Leu Gln Ile Arg Tyr 
                165                 170                 175     


Ser Gly Lys Ile Leu Lys Asn Asn Glu Thr Leu Val Gln His Gly Val 
            180                 185                 190         


Lys Pro Gln Glu Ile Val Gln Val Glu Ile Phe Ser Thr Asn Pro Asp 
        195                 200                 205             


Leu Tyr Pro Val Arg Arg Ile Asp Gly Leu Thr Asp Val Ser Gln Ile 
    210                 215                 220                 


Ile Thr Val Thr Val Gln Thr Gly Leu Asp Gln Tyr Gln Gln Val Pro 
225                 230                 235                 240 


Val Glu Ile Val Lys Ser Asp Phe His Lys Pro Phe Leu Gly Gly Phe 
                245                 250                 255     


Arg His Lys Val Thr Gly Val Glu Tyr His Asn Ala Gly Thr Gln Thr 
            260                 265                 270         


Val Pro Lys Arg Ile Pro Glu Arg Leu Ser Ile Phe Cys Arg Asp Thr 
        275                 280                 285             


Gln Thr Val Phe Gln Lys Lys Asn Leu Gln Gln Thr Thr Asn Thr Thr 
    290                 295                 300                 


Ser Thr Gln Met Thr Asn Ile Gly Val Tyr Val Ser Asn Met Thr Asp 
305                 310                 315                 320 


Lys Leu Val Thr Pro Gly Lys Tyr Phe Ser Ala Ala Glu Tyr His Ala 
                325                 330                 335     


Gln Arg Leu Lys Ala Val Ile Val Ile Gln Thr Tyr Tyr Arg Gln Trp 
            340                 345                 350         


His Ala Lys Ile Phe Val Glu Asn Leu Arg Arg Gln Lys Ser Leu Arg 
        355                 360                 365             


Leu Glu Trp Glu Thr Gln Gln Glu Leu Arg Lys Ile Arg Glu Lys Glu 
    370                 375                 380                 


Glu Trp Ile Lys Leu Asp Tyr His Arg Arg His Asn Pro Lys Thr Asn 
385                 390                 395                 400 


Glu Asp Phe Glu Phe Leu Tyr Asn Ala Leu Glu Phe Trp Arg Gln Glu 
                405                 410                 415     


Glu Leu Thr Arg Ile Asn Gln Ser Phe Thr Gly Ala Glu Arg Lys Ala 
            420                 425                 430         


Ala Leu Cys Glu Leu Leu Glu Lys Glu Thr Gln Ile Ile Ala Ser Ile 
        435                 440                 445             


Gly Arg His Arg Tyr Ile Ala Tyr Met Ala Asn Gln Glu Ala Ala Ile 
    450                 455                 460                 


Gln Ala Phe Leu Asp Lys Cys Ser Ala Pro Lys Ile Trp Arg Thr Pro 
465                 470                 475                 480 


Asn Gly Lys Thr Ile Glu Met Asp Thr Gln Phe Thr Ile Arg Ala Arg 
                485                 490                 495     


Glu Leu Gln Asn Ile Tyr Lys Cys Ile Met Leu Lys Asn Ile Ser Gln 
            500                 505                 510         


Asp Glu Arg Leu Asp Val Leu Leu Thr Leu Lys His Thr Val Lys Glu 
        515                 520                 525             


His Glu Cys Lys Leu Thr Gln Glu Ile Leu Glu Leu Ile Asp Arg Glu 
    530                 535                 540                 


Val Asp Leu Met Met Arg Gly Val Lys His His Asn Leu Glu Gly Leu 
545                 550                 555                 560 


Arg Lys Arg Ile Ala Thr Leu Phe Phe His Tyr Ile Lys Thr Pro Leu 
                565                 570                 575     


Phe Asn Pro Glu Val Ala Lys Tyr Leu Lys Val Pro Gln Asp Pro Leu 
            580                 585                 590         


Lys Phe Tyr Lys Lys Ile Tyr Phe Cys His Ser Cys Gln Leu Tyr Leu 
        595                 600                 605             


Pro Ser Thr Glu Phe Ser Val Ser Ser Thr Ser Arg Arg Ile Tyr Arg 
    610                 615                 620                 


Cys Arg Asn Cys Ile Asn Leu Gln Asn Glu Ala Gln Lys Arg Glu Ser 
625                 630                 635                 640 


Phe Leu Lys Tyr Lys Cys Leu Leu Gln Gln Leu Tyr Tyr Thr Glu Ala 
                645                 650                 655     


Asp Tyr Glu Asp Asp Ser Lys Ile Ala Phe Leu Met Gln Leu Gln Asp 
            660                 665                 670         


Ile Gln Tyr Leu Thr Glu Asn Ile Trp Ala Ser Gln Ser Val Leu Ser 
        675                 680                 685             


Ala Cys Asp Asn Leu Ser Asp Leu Val Met Val Arg Trp Asn Lys Ser 
    690                 695                 700                 


Leu Glu Trp Ser Pro Trp Asn Cys Ile Leu Leu Thr Lys Asp Glu Ala 
705                 710                 715                 720 


Ala Ala His Leu Lys Leu Thr Ser Ile Glu Glu Gly Tyr Glu Arg Ser 
                725                 730                 735     


Phe Ile His Lys Ile Lys His Lys His Ile Leu Ala Lys Asn Tyr Phe 
            740                 745                 750         


Ser Gln Val Pro Val Leu Ala Ser Phe Ile Leu Asp Asp Gly Glu Ile 
        755                 760                 765             


Asp Glu Ile Arg Trp Lys Tyr His Ser Asp Thr Thr Pro Lys Ile Ile 
    770                 775                 780                 


Glu Ser Gln Arg Pro Pro His 
785                 790     


<210> 5480
<211> 588
<212> PRT
<213> Homo sapiens

<400> 5480
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly His Arg 
    530                 535                 540                 


Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu Val Arg Gly Ser Pro 
545                 550                 555                 560 


Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly Ser Pro Ala Arg Met 
                565                 570                 575     


His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585             


<210> 5481
<211> 683
<212> PRT
<213> Homo sapiens

<400> 5481
Met Ala Leu Ser Lys Arg Glu Leu Asp Glu Leu Lys Pro Trp Ile Glu 
1               5                   10                  15      


Lys Thr Val Lys Arg Val Leu Gly Phe Ser Glu Pro Thr Val Val Thr 
            20                  25                  30          


Ala Ala Leu Asn Cys Val Gly Lys Gly Met Asp Lys Lys Lys Ala Ala 
        35                  40                  45              


Asp His Leu Lys Pro Phe Leu Asp Asp Ser Thr Leu Arg Phe Val Asp 
    50                  55                  60                  


Lys Leu Phe Glu Ala Val Glu Glu Gly Arg Ser Ser Arg His Ser Lys 
65                  70                  75                  80  


Ser Ser Ser Asp Arg Ser Arg Lys Arg Glu Leu Lys Glu Val Phe Gly 
                85                  90                  95      


Asp Asp Ser Glu Ile Ser Lys Glu Ser Ser Gly Val Lys Lys Arg Arg 
            100                 105                 110         


Ile Pro Arg Phe Glu Glu Val Glu Glu Glu Pro Glu Val Ile Pro Gly 
        115                 120                 125             


Pro Pro Ser Glu Ser Pro Gly Met Leu Thr Lys Leu Gln Ile Lys Gln 
    130                 135                 140                 


Met Met Glu Ala Ala Thr Arg Gln Ile Glu Glu Arg Lys Lys Gln Leu 
145                 150                 155                 160 


Ser Phe Ile Ser Pro Pro Thr Pro Gln Pro Lys Thr Pro Ser Ser Ser 
                165                 170                 175     


Gln Pro Glu Arg Leu Pro Ile Gly Asn Thr Ile Gln Pro Ser Gln Ala 
            180                 185                 190         


Ala Thr Phe Met Asn Asp Ala Ile Glu Lys Ala Arg Lys Ala Ala Glu 
        195                 200                 205             


Leu Gln Ala Arg Ile Gln Ala Gln Leu Ala Leu Lys Pro Gly Leu Ile 
    210                 215                 220                 


Gly Asn Ala Asn Met Val Gly Leu Ala Asn Leu His Ala Met Gly Ile 
225                 230                 235                 240 


Ala Pro Pro Lys Val Glu Leu Lys Asp Gln Thr Lys Pro Thr Pro Leu 
                245                 250                 255     


Ile Leu Asp Glu Gln Gly Arg Thr Val Asp Ala Thr Gly Lys Glu Ile 
            260                 265                 270         


Glu Leu Thr His Arg Met Pro Thr Leu Lys Ala Asn Ile Arg Ala Val 
        275                 280                 285             


Lys Arg Glu Gln Phe Lys Gln Gln Leu Lys Glu Lys Pro Ser Glu Asp 
    290                 295                 300                 


Met Glu Ser Asn Thr Phe Phe Asp Pro Arg Val Ser Ile Ala Pro Ser 
305                 310                 315                 320 


Gln Arg Gln Arg Arg Thr Phe Lys Phe His Asp Lys Gly Lys Phe Glu 
                325                 330                 335     


Lys Ile Ala Gln Arg Leu Arg Thr Lys Ala Gln Leu Glu Lys Leu Gln 
            340                 345                 350         


Ala Glu Ile Ser Gln Ala Ala Arg Lys Thr Gly Ile His Thr Ser Thr 
        355                 360                 365             


Arg Leu Ala Leu Ile Ala Pro Lys Lys Glu Leu Lys Glu Gly Asp Ile 
    370                 375                 380                 


Pro Glu Ile Glu Trp Trp Asp Ser Tyr Ile Ile Pro Asn Gly Phe Asp 
385                 390                 395                 400 


Leu Thr Glu Glu Asn Pro Lys Arg Glu Asp Tyr Phe Gly Ile Thr Asn 
                405                 410                 415     


Leu Val Glu His Pro Ala Gln Leu Asn Pro Pro Val Asp Asn Asp Thr 
            420                 425                 430         


Pro Val Thr Leu Gly Val Tyr Leu Thr Lys Lys Glu Gln Lys Lys Leu 
        435                 440                 445             


Arg Arg Gln Thr Arg Arg Glu Ala Gln Lys Glu Leu Gln Glu Lys Val 
    450                 455                 460                 


Arg Leu Gly Leu Met Pro Pro Pro Glu Pro Lys Val Arg Ile Ser Asn 
465                 470                 475                 480 


Leu Met Arg Val Leu Gly Thr Glu Ala Val Gln Asp Pro Thr Lys Val 
                485                 490                 495     


Glu Ala His Val Arg Ala Gln Met Ala Lys Arg Gln Lys Ala His Glu 
            500                 505                 510         


Glu Ala Asn Ala Ala Arg Lys Leu Thr Ala Glu Gln Arg Lys Val Lys 
        515                 520                 525             


Lys Ile Lys Lys Leu Lys Glu Asp Ile Ser Gln Gly Val His Ile Ser 
    530                 535                 540                 


Val Tyr Arg Val Arg Asn Leu Ser Asn Pro Ala Lys Lys Phe Lys Ile 
545                 550                 555                 560 


Glu Ala Asn Ala Gly Gln Leu Tyr Leu Thr Gly Val Val Val Leu His 
                565                 570                 575     


Lys Asp Val Asn Val Val Val Val Glu Gly Gly Pro Lys Ala Gln Lys 
            580                 585                 590         


Lys Phe Lys Arg Leu Met Leu His Arg Ile Lys Trp Asp Glu Gln Thr 
        595                 600                 605             


Ser Asn Thr Lys Gly Asp Asp Asp Glu Glu Ser Asp Glu Glu Ala Val 
    610                 615                 620                 


Lys Lys Thr Asn Lys Cys Val Leu Val Trp Glu Gly Thr Ala Lys Asp 
625                 630                 635                 640 


Arg Ser Phe Gly Glu Met Lys Phe Lys Gln Cys Pro Thr Glu Asn Met 
                645                 650                 655     


Ala Arg Glu His Phe Lys Lys His Gly Ala Glu His Tyr Trp Asp Leu 
            660                 665                 670         


Ala Leu Ser Glu Ser Val Leu Glu Ser Thr Asp 
        675                 680             


<210> 5482
<211> 645
<212> PRT
<213> Homo sapiens

<400> 5482
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Gln Pro Leu His Phe 
65                  70                  75                  80  


Leu Thr Trp Asp Thr Cys Tyr Phe His Tyr Leu Val Pro Thr Pro Met 
                85                  90                  95      


Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln 
            100                 105                 110         


Asp Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr 
        115                 120                 125             


Asp Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg 
    130                 135                 140                 


Leu His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro 
145                 150                 155                 160 


Arg Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr 
                165                 170                 175     


His Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys 
            180                 185                 190         


Val Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val 
        195                 200                 205             


Lys Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile 
    210                 215                 220                 


Leu His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val 
225                 230                 235                 240 


Ile Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser 
                245                 250                 255     


Gly Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn 
            260                 265                 270         


Leu Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg 
        275                 280                 285             


Val Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val 
    290                 295                 300                 


Ala Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val 
305                 310                 315                 320 


Ala Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val 
                325                 330                 335     


Phe His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His 
            340                 345                 350         


Pro Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp 
        355                 360                 365             


Asp Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser 
    370                 375                 380                 


Ala Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr 
385                 390                 395                 400 


Gln Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys 
                405                 410                 415     


Ser Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu 
            420                 425                 430         


Val Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro 
        435                 440                 445             


Thr Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val 
    450                 455                 460                 


Tyr Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe 
465                 470                 475                 480 


Glu Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val 
                485                 490                 495     


Gly Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp 
            500                 505                 510         


Thr Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe 
        515                 520                 525             


Glu Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His 
    530                 535                 540                 


Pro Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp 
545                 550                 555                 560 


Asn Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu 
                565                 570                 575     


Gly Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu 
            580                 585                 590         


Val Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly 
        595                 600                 605             


Glu Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr 
    610                 615                 620                 


Leu Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr 
625                 630                 635                 640 


Val Glu Leu Ser Ala 
                645 


<210> 5483
<211> 2601
<212> PRT
<213> Homo sapiens

<400> 5483
Met Lys Arg Lys Val Val Asn Thr His Lys Leu Arg Leu Ser Pro Asn 
1               5                   10                  15      


Glu Glu Ala Phe Ile Leu Lys Glu Asp Tyr Glu Arg Arg Arg Lys Leu 
            20                  25                  30          


Arg Leu Leu Gln Val Arg Glu Gln Glu Arg Asp Ile Ala Leu Gln Ile 
        35                  40                  45              


Arg Glu Asp Ile Lys Gln Arg Arg Asn Gln Gln Phe Thr Arg Leu Ala 
    50                  55                  60                  


Glu Glu Leu Arg Ala Glu Trp Glu Glu Ser Gln Thr Gln Lys Ile Gln 
65                  70                  75                  80  


Asn Leu Glu Lys Leu Tyr Leu Ala Ser Leu Arg Ser Met Gly Glu Gly 
                85                  90                  95      


His Arg Gln Ala Lys Glu Asn Glu Pro Asp Leu Asp Ala Leu Ala Gln 
            100                 105                 110         


Arg Ala Ala Glu Arg Lys Arg Lys Ala Asp Leu Arg His Lys Glu Ala 
        115                 120                 125             


Leu Lys Val Gln Lys Asn Gln Lys Glu Ile Leu Leu Lys Gln Lys Thr 
    130                 135                 140                 


Trp His Ile Lys Ala Arg Lys Glu Ala Leu Leu Val Glu Lys Glu Arg 
145                 150                 155                 160 


Ser Ala Lys Ile Thr Ser Leu Pro Pro Pro Pro Pro Thr Leu Phe Glu 
                165                 170                 175     


Asn Ile Glu Val Lys Arg Ile Ser Ala Val Lys Thr Asn Ser Ser Thr 
            180                 185                 190         


Tyr His His Leu His Thr Phe Val Asn Arg Glu Thr Asp Thr Lys Arg 
        195                 200                 205             


Pro Asp Ala Arg Leu Ala Ala Glu Glu Glu Ala Lys Arg Leu Glu Glu 
    210                 215                 220                 


Leu Gln Lys Gln Ala Ala Gln Glu Arg Met Glu Arg Phe Glu Lys Ala 
225                 230                 235                 240 


His Val Arg Gly Phe Gln Ala Met Lys Lys Ile His Leu Ala Gln Asn 
                245                 250                 255     


Gln Glu Lys Leu Met Lys Glu Leu Lys Gln Leu Gln Gln Glu Asp Leu 
            260                 265                 270         


Ala Arg Arg Arg Gln Thr Val Ala Gln Met Pro Pro Gln Leu Val Glu 
        275                 280                 285             


Leu Pro Tyr Lys Arg Ser Glu Met Lys Glu Asp Trp Gln Arg Glu Leu 
    290                 295                 300                 


Glu Phe Ala Phe Glu Asp Met Tyr Asn Ala Asp Arg Lys Val Lys Gly 
305                 310                 315                 320 


Asn Leu Ile Leu His Leu Glu Pro Glu Pro Leu Pro Thr Val Thr Asn 
                325                 330                 335     


Gln Ile Gln Asp Glu Glu Leu Asp Leu Ser Met Glu Gln Glu Asn Leu 
            340                 345                 350         


Gly Ala Ala Glu Asp Leu Pro Val Thr Glu Ala Glu Ile Cys Ser Ser 
        355                 360                 365             


Glu Thr Asp Val Pro Leu Val Met Lys Thr Gln Gln Ile Pro Ser Lys 
    370                 375                 380                 


Val Leu Phe Lys Lys Leu Leu Asn Lys Ile Arg Ser Gln Lys Ser Leu 
385                 390                 395                 400 


Trp Thr Ile Lys Ser Met Ser Glu Asp Glu Ser Glu Met Ile Thr Thr 
                405                 410                 415     


Val Ser Glu Ile Glu Ser Lys Ala Pro Thr Val Glu Ser Gly Thr Ile 
            420                 425                 430         


Ala Ser Lys Glu Arg Thr Leu Ser Ser Gly Gln Glu Gln Val Val Glu 
        435                 440                 445             


Ser Asp Thr Leu Thr Ile Glu Ser Gly Pro Leu Ala Ser Glu Asp Lys 
    450                 455                 460                 


Pro Leu Ser Cys Gly Thr Asn Ser Gly Lys Glu Gln Glu Ile Asn Glu 
465                 470                 475                 480 


Thr Leu Pro Ile Thr Thr Val Ala Gln Ser Ser Val Leu Leu His Pro 
                485                 490                 495     


Gln Glu Ala Ala Ala Arg Ile Arg Met Ser Ala Arg Gln Lys Gln Ile 
            500                 505                 510         


Met Glu Ile Glu Glu Gln Lys Gln Lys Gln Leu Glu Leu Leu Glu Gln 
        515                 520                 525             


Ile Glu Gln Gln Lys Leu Arg Leu Glu Thr Asp Cys Phe Arg Ala Gln 
    530                 535                 540                 


Leu Glu Glu Glu Lys Arg Lys Lys Thr Gln Pro Thr Gly Val Gly Ile 
545                 550                 555                 560 


Ala Pro Ala Ser Cys Pro Val Ile Ser Asp Glu Asp Ser His Arg Gln 
                565                 570                 575     


Met Ile Arg Asn Tyr Gln His Gln Leu Leu Gln Gln Asn Arg Leu His 
            580                 585                 590         


Arg Gln Ser Val Glu Thr Ala Arg Lys Gln Leu Leu Glu Tyr Gln Thr 
        595                 600                 605             


Met Leu Lys Gly Arg Cys Pro Ser Val Ser Ala Pro Ser Leu Ile Thr 
    610                 615                 620                 


Asp Ser Val Ile Ser Val Pro Ser Trp Lys Ser Glu Arg Pro Thr Ala 
625                 630                 635                 640 


Ile Ser Glu His Trp Asp Gln Gly Gln Arg Leu Lys Leu Ser Pro Asn 
                645                 650                 655     


Lys Tyr Gln Pro Ile Gln Pro Ile Gln Thr Ser Lys Leu Glu Gln Asp 
            660                 665                 670         


His Phe Gln Val Ala Arg Gln Asn His Phe Pro Gln Arg Gln Val Glu 
        675                 680                 685             


Thr Thr Glu Thr Leu Arg Ala Ser Asp Ile Leu Thr Asn Gln Ala Leu 
    690                 695                 700                 


Glu Ser Gln Glu His Leu Arg Gln Phe Ser Gln Thr Glu Thr Gln Gln 
705                 710                 715                 720 


Arg Asp Tyr Lys Leu Val Pro Lys Asp Ser Glu Thr Leu Ser Arg Ala 
                725                 730                 735     


Leu Ser His Asp Arg Gln Leu Ile Ser Gln Asp Ala Arg Lys Ile Ser 
            740                 745                 750         


Glu Thr Phe Gly Ala Thr Thr Phe Gln Ser Leu Glu Ser Gln Gln Leu 
        755                 760                 765             


Phe Ser Glu Asn Ser Glu Asn Ile Ser Tyr His Leu Thr Glu Pro Ser 
    770                 775                 780                 


Ser Phe Val Pro Leu Val Pro Gln His Ser Phe Ser Ser Leu Pro Val 
785                 790                 795                 800 


Lys Val Glu Ser Gly Lys Ile Gln Glu Pro Phe Ser Ala Met Ser Lys 
                805                 810                 815     


Ser Thr Val Ser Thr Ser His Ser Ile Ile Ser Gln Met His Asp Arg 
            820                 825                 830         


Pro Leu Leu Pro Ser Glu Asn Ile Thr Ala Gln Gln Gly Asn Met Lys 
        835                 840                 845             


Ala Leu Gln Glu Gln Leu Asp Leu Gln Lys Lys Val Leu Gln Ala Thr 
    850                 855                 860                 


Gln Glu Ala Gln Glu Gln Leu Leu Leu Cys Lys Gln Lys Glu Val Glu 
865                 870                 875                 880 


Gln Gln Thr Gly Leu Ser Val Phe Leu Pro Leu Val Thr Pro Asp Ser 
                885                 890                 895     


Ser Ala Leu Leu Pro Ser Ala Lys Ala Asp Leu Gly Arg Ile Gln Glu 
            900                 905                 910         


Ser Ser Pro Thr Lys Asn Asn Ile Ala Val Ser Ser Asp His His Val 
        915                 920                 925             


Ile Ser Gln Leu Gln Asp Lys Arg Leu Ser Leu Ser Gln Pro Ile Leu 
    930                 935                 940                 


Ser Gln Gln Asn Asn Phe Lys Phe Leu Gln Glu Gln Leu Asn Ile Gln 
945                 950                 955                 960 


Lys Asp Ser Leu Gln Ala Arg Arg Glu Ala Gln Glu Val Leu Tyr Val 
                965                 970                 975     


His Lys Gln Ser Glu Leu Asp Arg Arg Val Cys Ser Glu Gln Ala Glu 
            980                 985                 990         


Pro Ser Phe Pro Phe Gln Val Ala  Gln His Thr Phe Thr  Ser Leu Pro 
        995                 1000                 1005             


Ser Ala  Asp Thr Lys Ser Gly  Lys Ile Gln Glu Gln  His Ser Ser 
    1010                 1015                 1020             


Lys Ser  Glu Lys Gly Leu Val  Ser Cys Gln Ser Asp  Ile Pro Ile 
    1025                 1030                 1035             


Ser Gln  Asp Gly Ser Leu Ser  Phe Leu Gln Gln Phe  Leu Pro Leu 
    1040                 1045                 1050             


His Asp  Ser Leu Lys Leu Leu  Gln Glu Gln Leu Thr  Lys Gln Arg 
    1055                 1060                 1065             


Asp Thr  Leu Gln Ala Arg His  Glu Ala Gln Val Glu  Leu Leu Leu 
    1070                 1075                 1080             


His Arg  Gln Arg Asp Leu Gly  Asp Ser Lys Ser Gly  Leu Val Ser 
    1085                 1090                 1095             


Ser Ser  Ser Ser Pro Val Val  Val Gln His Ser Val  Ala Ser Gln 
    1100                 1105                 1110             


Ala Ser  Ala Lys Ala Glu Pro  Arg Arg Ile Gln Glu  Leu Tyr Leu 
    1115                 1120                 1125             


Ser Glu  Lys Glu Asn Val Gly  Pro Ser Cys His Leu  Ile Ile Pro 
    1130                 1135                 1140             


Thr Phe  Gln Asp Lys Ser Leu  Ser Phe Pro Gln His  Ser Leu Ala 
    1145                 1150                 1155             


Gln Gln  Glu Asn Leu Thr Ile  Leu Gln Glu Gln Ser  Gln Ile Gln 
    1160                 1165                 1170             


Arg Val  Ile Leu Gly Ala Lys  Glu Gly Thr Gln Glu  Phe Val His 
    1175                 1180                 1185             


Thr Glu  Ser Glu Leu Glu Lys  Arg Ile Ser Ser Glu  Gln Thr Gly 
    1190                 1195                 1200             


Thr Ser  Ser Ser Leu Ser Gln  Val Asp Glu Ser Glu  Arg Phe Gln 
    1205                 1210                 1215             


Glu Cys  Ile Ser Ile Lys Ser  Asp Ser Thr Ile Pro  Leu Ser His 
    1220                 1225                 1230             


Pro Lys  Ile Pro Arg Cys Gln  Glu Arg Leu Leu Arg  Val Ser Gln 
    1235                 1240                 1245             


His Met  Leu Pro Leu Gln Asp  Asn Leu Glu Glu His  Gln Ala Trp 
    1250                 1255                 1260             


Leu Asp  Thr Glu Lys Glu Ala  Phe His Phe Ser Gln  Lys Thr Gln 
    1265                 1270                 1275             


Glu Asn  Thr Ser Ser Glu Gln  Thr Gly Ser Ser Ser  Phe Ile Pro 
    1280                 1285                 1290             


Gln Leu  Val Gln Leu Ser Phe  Thr Ser Leu Ala Ser  Ala Glu Ser 
    1295                 1300                 1305             


Gly Thr  Ile Leu Glu Pro Leu  Phe Thr Glu Ser Glu  Ser Lys Ile 
    1310                 1315                 1320             


Phe Ser  Ser His Leu Gln Ile  Pro Gln Leu Gln Asp  Arg Leu Leu 
    1325                 1330                 1335             


Arg Ile  Ser Gln Leu Ile Gln  Pro Gln Gln Asp Asn  Leu Lys Ala 
    1340                 1345                 1350             


Leu Gln  Glu Gln Leu Ala Thr  Gln Arg Glu Ala Ile  Ile Leu Ala 
    1355                 1360                 1365             


Arg Gln  Glu Ala Arg Glu Glu  Leu Leu Leu His Gln  Ser Glu Trp 
    1370                 1375                 1380             


Glu Gly  Arg Ile Ser Pro Glu  Gln Val Asp Thr Ser  Ser Leu Pro 
    1385                 1390                 1395             


Leu Val  Pro Gln His Ser Phe  Ala Ser Leu Pro Leu  Asn Glu Ser 
    1400                 1405                 1410             


Glu Arg  Asn Gln Glu Pro Cys  Ser Ile Asn Ser Asp  Asn Ile Val 
    1415                 1420                 1425             


Ser Ser  Gly His Ser Glu Ile  Pro Thr Leu Pro Asp  Gly Leu Leu 
    1430                 1435                 1440             


Gly Leu  Ser His Leu Val Leu  Pro Gln Gln Asp Asn  Leu Ile Ala 
    1445                 1450                 1455             


Leu Glu  Glu His Leu His Ala  Gln Thr Asp Phe Leu  Pro Ser Ile 
    1460                 1465                 1470             


Glu Lys  Thr Gln Lys Glu Leu  Val Leu Ser Lys Pro  Cys Lys Phe 
    1475                 1480                 1485             


Glu Glu  Lys Val Ser Ser Glu  His Phe Ile Gln Ser  His His Gly 
    1490                 1495                 1500             


Asp Leu  Gln Ala Leu Gln Gln  Gln Leu Asp Thr Gln  Lys Lys Ala 
    1505                 1510                 1515             


Ile Arg  Ser Ile Gln Glu Val  Gln Glu Glu Leu Leu  Leu Gln Arg 
    1520                 1525                 1530             


Leu Ser  Glu Leu Glu Lys Arg  Val Ser Ser Glu Gln  Val Cys Ser 
    1535                 1540                 1545             


Ser Ser  Phe Val Ser Gln Val  Pro Val Ala Asp Ser  Glu Arg Thr 
    1550                 1555                 1560             


Gln Lys  Ser Phe Pro Thr Lys  Ser Asn Asp Thr Leu  Pro Ser Ser 
    1565                 1570                 1575             


His Arg  Glu Ile Pro Arg Leu  Gln Asp Arg Leu Leu  Ser Leu Ser 
    1580                 1585                 1590             


Lys Pro  Ile Leu Pro Gln Gln  Asp Asn Met Thr Ala  Gln Leu Asp 
    1595                 1600                 1605             


Ala Gln  Arg Glu Val Met Tyr  Ser Tyr Glu Lys Pro  Gln Glu Glu 
    1610                 1615                 1620             


Leu Ser  Leu Asn Lys Gln Arg  Lys Leu Asn Lys Ser  Glu Ser Ala 
    1625                 1630                 1635             


Glu His  Thr Ile Pro Ser Leu  Phe Leu Pro Lys Glu  Thr Glu His 
    1640                 1645                 1650             


Ser Phe  Ile Pro Leu Pro Phe  Ala Glu Ala Lys Pro  Lys Ser Thr 
    1655                 1660                 1665             


Cys Glu  Leu Tyr Ser Ser Gln  Asn Glu His Ala Ala  Pro Pro Ser 
    1670                 1675                 1680             


Asn Pro  Val Ile Pro Gly Phe  Gln Asp Arg Leu Leu  Ser Phe Ser 
    1685                 1690                 1695             


Gln Ser  Val Leu Thr Gln Gln  Asp Asn Leu Gly Leu  Gln Lys Gln 
    1700                 1705                 1710             


Leu Asp  Leu Gln Arg Glu Val  Leu His Tyr Ser Gln  Lys Ala Gln 
    1715                 1720                 1725             


Glu Lys  Leu Leu Val Gln Arg  Gln Thr Ala Leu Gln  Gln Gln Ile 
    1730                 1735                 1740             


Gln Lys  His Glu Glu Thr Leu  Lys Asp Phe Phe Lys  Asp Ser Gln 
    1745                 1750                 1755             


Ile Ser  Lys Pro Thr Val Glu  Asn Asp Leu Lys Thr  Gln Lys Met 
    1760                 1765                 1770             


Gly Gln  Leu Arg Asp Trp Phe  Pro Asn Thr Gln Asp  Leu Ala Gly 
    1775                 1780                 1785             


Asn Asp  Gln Glu Asn Ile Arg  His Ala Asp Arg Asn  Asn Ser Asp 
    1790                 1795                 1800             


Asp Asn  His Leu Ala Ser Glu  Asp Thr Ser Ala Lys  Gln Ser Gly 
    1805                 1810                 1815             


Glu His  Leu Glu Lys Asp Leu  Gly Arg Arg Ser Ser  Lys Pro Pro 
    1820                 1825                 1830             


Val Ala  Lys Val Lys Cys Gly  Leu Asp Leu Asn Gln  His Glu Leu 
    1835                 1840                 1845             


Ser Ala  Ile Gln Glu Val Glu  Ser Pro Ala Ile Gly  Arg Thr Ser 
    1850                 1855                 1860             


Ile Leu  Gly Lys Pro Gly Ile  Tyr Glu Asp Arg Asp  Pro Leu Arg 
    1865                 1870                 1875             


Val Ser  Ile Ser Arg Glu Gln  Ser Phe Phe Gly Ser  Pro Leu Ala 
    1880                 1885                 1890             


His Asp  Pro Phe Ser Cys Leu  Gln Leu Val Gly Gln  Glu Asn Val 
    1895                 1900                 1905             


Cys Gly  Asp Asp Tyr Asp Glu  Ala Val Lys Leu Lys  Glu Ser Val 
    1910                 1915                 1920             


Val Glu  Asn His Ala Val Leu  Ser Tyr Ala Val Glu  Glu Glu His 
    1925                 1930                 1935             


Ala Tyr  Leu Gly Pro Thr Val  Lys Pro Asp Asp Lys  Ala Lys Thr 
    1940                 1945                 1950             


Leu Ser  Tyr Glu Pro Leu Ser  Ser Ala Thr Val Ser  Thr Gly Ser 
    1955                 1960                 1965             


Leu Leu  Ser Tyr Glu Asn Thr  Asp Leu Ser Leu Thr  Asp Pro Glu 
    1970                 1975                 1980             


Ser Phe  Ser Glu His Met Asp  Asp Ser Lys Gln Glu  Ser Thr Thr 
    1985                 1990                 1995             


Ser Lys  Glu Glu Glu Thr Asn  Ile Ile Ser Ser Ile  Val Pro Ser 
    2000                 2005                 2010             


Thr Gln  Asp Ile Tyr Gln Arg  Gln Asn Ser Ser Asp  Val His Lys 
    2015                 2020                 2025             


Ser Leu  Leu Pro Ala Val Asp  Glu Thr Thr Cys Gly  His Thr His 
    2030                 2035                 2040             


Phe Gln  Gln Met Ile Asp Lys  Tyr Ile Asn Glu Ala  Asn Leu Ile 
    2045                 2050                 2055             


Pro Glu  Lys Thr Asp Leu Gln  Glu Leu Glu His Ile  Phe Pro Asn 
    2060                 2065                 2070             


Leu His  His Gln Leu Phe Lys  Pro Leu Glu Pro His  Pro Asp Phe 
    2075                 2080                 2085             


Asp Leu  Ser Ser Ser Ser Ser  Gly Ile Ser Pro Asp  Asn Arg Asp 
    2090                 2095                 2100             


Phe Tyr  Gln Arg Ser Asp Ser  Ser Ser Glu Ser His  Cys Ala Thr 
    2105                 2110                 2115             


Gly Leu  Ser Lys Ser Thr Val  Tyr Phe Thr Ala Leu  Arg Arg Thr 
    2120                 2125                 2130             


Ser Met  His Ser Ser Leu Asn  Thr Ser Pro Asn Gln  Gln Pro Asp 
    2135                 2140                 2145             


Thr Asn  Leu Ala His Val Gly  Ala His Ser Phe Ala  Thr Glu Asn 
    2150                 2155                 2160             


Ile Ile  Gly Gly Ser Glu Gln  Cys Phe Glu Gln Leu  Gln Pro Glu 
    2165                 2170                 2175             


Tyr Ser  Ser Gln Glu Glu Ser  Gln His Ala Asp Leu  Pro Ser Ile 
    2180                 2185                 2190             


Phe Ser  Ile Glu Ala Arg Asp  Ser Ser Gln Gly Met  Lys Asn Gln 
    2195                 2200                 2205             


Asn Tyr  Pro Ser Glu Glu His  Thr Glu Ile Leu Gln  Asn Lys Lys 
    2210                 2215                 2220             


Lys Ile  Val His Phe Gln Leu  Ser Ile Gly Asn Leu  Ser Ser Val 
    2225                 2230                 2235             


Tyr Ser  Ser Ser Asp Glu Ala  Asn Val Phe Asp Gln  Leu Asn Val 
    2240                 2245                 2250             


Gln His  Ser Thr Pro Cys Gly  Ser Asn Ser Ser Glu  Cys Ser Thr 
    2255                 2260                 2265             


Lys His  Gln Leu Glu Ser Arg  Lys Glu Ser Met Gly  Phe Glu Glu 
    2270                 2275                 2280             


Leu Ser  Lys Arg Gly Val Val  Thr Met Leu Gln Ser  Gln Gly Leu 
    2285                 2290                 2295             


Ile Glu  Asp Asn Lys Asn Glu  Thr Cys Arg Val Leu  Asp Ile Asn 
    2300                 2305                 2310             


Pro Gln  Val Glu Glu Thr Asp  Ser Arg Leu Cys Val  Arg Thr Val 
    2315                 2320                 2325             


Glu Met  Gly Thr Ser Ile Gln  Ala Pro Tyr Ser Leu  Thr Thr Gln 
    2330                 2335                 2340             


Asn Glu  Lys Tyr Phe Glu Asn  Ser Ala Glu Thr Asp  Ile Pro Lys 
    2345                 2350                 2355             


Ile Thr  Lys Lys Leu Ser Gln  Leu Gly Glu Ser Glu  Leu Phe Ala 
    2360                 2365                 2370             


Ser Ser  Gly Ser Phe Ser Leu  Gln Ser Ser Ile Pro  Val Trp Glu 
    2375                 2380                 2385             


Thr Glu  Thr Gly His Gly Ile  Met Glu Glu Pro Glu  Leu Thr Leu 
    2390                 2395                 2400             


Ile Ser  Thr Thr Asp Thr Ser  Ile Ala Glu Met Asp  Phe Ala Asn 
    2405                 2410                 2415             


Leu Thr  Leu Glu Glu Lys Ser  Glu Asn Glu Ala Lys  Cys Phe Phe 
    2420                 2425                 2430             


Gln Val  Ser Glu Phe Leu Pro  Leu Val Ser Ala Thr  Glu Ala Ser 
    2435                 2440                 2445             


Asp Tyr  Pro Ala Val Ser Glu  Leu Ser Ile Glu Lys  Pro Arg Thr 
    2450                 2455                 2460             


Ala Ser  Thr Glu Thr Pro Arg  Arg Leu Thr Pro Val  Pro Gly Ser 
    2465                 2470                 2475             


Leu Gln  Glu Ala Phe Ile Lys  Arg Lys Lys Ser Phe  Met Glu Arg 
    2480                 2485                 2490             


Ser His  Gln Arg Gln Lys Glu  Ile Arg Asn Lys Ile  His Val Ser 
    2495                 2500                 2505             


Glu Asn  Ser Gln Ile Lys Thr  Val Lys Glu Lys Pro  Ser Ile Ser 
    2510                 2515                 2520             


Ser Ser  Val Ser Arg Leu Lys  Gly Val Asn Lys Val  Arg Ala Ser 
    2525                 2530                 2535             


Phe Pro  Glu Asp Arg Lys Thr  Thr Gln Ala Leu Arg  His Gln Arg 
    2540                 2545                 2550             


Gly Leu  Arg Leu Tyr Asn Gln  Leu Ala Glu Val Lys  Gln Gln Lys 
    2555                 2560                 2565             


Glu Glu  Lys Thr Lys Gln Glu  Ala Tyr Ala Gln Asn  Arg Ala Arg 
    2570                 2575                 2580             


Ala Lys  Glu Phe His Lys Lys  Thr Leu Glu Lys Leu  Arg Ala Lys 
    2585                 2590                 2595             


Asn Thr  Cys 
    2600     


<210> 5484
<211> 798
<212> PRT
<213> Homo sapiens

<400> 5484
Met Ala Ala Ser Leu Pro Gly Pro Gly Ser Arg Leu Phe Arg Thr Tyr 
1               5                   10                  15      


Gly Ala Ala Asp Gly Arg Arg Gln Arg Arg Pro Gly Arg Glu Ala Ala 
            20                  25                  30          


Gln Trp Phe Pro Pro Gln Asp Arg Arg Arg Phe Phe Asn Ser Ser Gly 
        35                  40                  45              


Ser Ser Asp Ala Ser Ile Gly Asp Pro Ser Gln Ser Asp Asp Pro Asp 
    50                  55                  60                  


Asp Pro Asp Asp Pro Asp Phe Pro Gly Ser Pro Val Arg Arg Arg Arg 
65                  70                  75                  80  


Arg Arg Pro Gly Gly Arg Val Pro Lys Asp Arg Pro Ser Leu Thr Val 
                85                  90                  95      


Thr Pro Lys Arg Trp Lys Leu Arg Ala Arg Pro Ser Leu Thr Val Thr 
            100                 105                 110         


Pro Arg Arg Leu Gly Leu Arg Ala Arg Pro Pro Gln Lys Cys Ser Thr 
        115                 120                 125             


Pro Cys Gly Pro Leu Arg Leu Pro Pro Phe Pro Ser Arg Asp Ser Gly 
    130                 135                 140                 


Arg Leu Ser Pro Asp Leu Ser Val Cys Gly Gln Pro Arg Asp Gly Asp 
145                 150                 155                 160 


Glu Leu Gly Ile Ser Ala Ser Leu Phe Ser Ser Leu Ala Ser Pro Cys 
                165                 170                 175     


Pro Gly Ser Pro Thr Pro Arg Asp Ser Val Ile Ser Ile Gly Thr Ser 
            180                 185                 190         


Ala Cys Leu Val Ala Ala Ser Ala Val Pro Ser Gly Leu His Leu Pro 
        195                 200                 205             


Glu Val Ser Leu Asp Arg Ala Ser Leu Pro Cys Ser Gln Glu Glu Ala 
    210                 215                 220                 


Thr Gly Gly Ala Lys Asp Thr Arg Met Val His Gln Thr Arg Ala Ser 
225                 230                 235                 240 


Leu Arg Ser Val Leu Phe Gly Leu Met Asn Ser Gly Thr Pro Glu Asp 
                245                 250                 255     


Ser Glu Phe Arg Ala Asp Gly Lys Asn Met Arg Glu Ser Cys Cys Lys 
            260                 265                 270         


Arg Lys Leu Val Val Gly Asn Gly Pro Glu Gly Pro Gly Leu Ser Ser 
        275                 280                 285             


Thr Gly Lys Arg Arg Ala Thr Gly Gln Asp Ser Cys Gln Glu Arg Gly 
    290                 295                 300                 


Leu Gln Glu Ala Val Arg Arg Glu His Gln Glu Ala Ser Val Pro Lys 
305                 310                 315                 320 


Gly Arg Ile Val Pro Arg Gly Ile Asp Arg Leu Glu Arg Thr Arg Ser 
                325                 330                 335     


Ser Arg Lys Ser Lys His Gln Glu Ala Thr Glu Thr Ser Leu Leu His 
            340                 345                 350         


Ser His Arg Phe Lys Lys Gly Gln Lys Leu Gly Lys Asp Ser Phe Pro 
        355                 360                 365             


Thr Gln Asp Leu Thr Pro Leu Gln Asn Val Cys Phe Trp Thr Lys Thr 
    370                 375                 380                 


Arg Ala Ser Phe Ser Phe His Lys Lys Lys Ile Val Thr Asp Val Ser 
385                 390                 395                 400 


Glu Val Cys Ser Ile Tyr Thr Thr Ala Thr Ser Leu Ser Gly Ser Leu 
                405                 410                 415     


Leu Ser Glu Cys Ser Asn Arg Pro Val Met Asn Arg Thr Ser Gly Ala 
            420                 425                 430         


Pro Ser Ser Trp His Ser Ser Ser Met Tyr Leu Leu Ser Pro Leu Asn 
        435                 440                 445             


Thr Leu Ser Ile Ser Asn Lys Lys Ala Ser Asp Ala Glu Lys Val Tyr 
    450                 455                 460                 


Gly Glu Cys Ser Gln Lys Gly Pro Val Pro Phe Ser His Cys Leu Pro 
465                 470                 475                 480 


Thr Glu Lys Leu Gln Arg Cys Glu Lys Ile Gly Glu Gly Val Phe Gly 
                485                 490                 495     


Glu Val Phe Gln Thr Ile Ala Asp His Thr Pro Val Ala Ile Lys Ile 
            500                 505                 510         


Ile Ala Ile Glu Gly Pro Asp Leu Val Asn Gly Ser His Gln Lys Thr 
        515                 520                 525             


Phe Glu Glu Ile Leu Pro Glu Ile Ile Ile Ser Lys Glu Leu Ser Leu 
    530                 535                 540                 


Leu Ser Gly Glu Val Cys Asn Arg Thr Glu Gly Phe Ile Gly Leu Asn 
545                 550                 555                 560 


Ser Val His Cys Val Gln Gly Ser Tyr Pro Pro Leu Leu Leu Lys Ala 
                565                 570                 575     


Trp Asp His Tyr Asn Ser Thr Lys Gly Ser Ala Asn Asp Arg Pro Asp 
            580                 585                 590         


Phe Phe Lys Asp Asp Gln Leu Phe Ile Val Leu Glu Phe Glu Phe Gly 
        595                 600                 605             


Gly Ile Asp Leu Glu Gln Met Arg Thr Lys Leu Ser Ser Leu Ala Thr 
    610                 615                 620                 


Ala Lys Ser Ile Leu His Gln Leu Thr Ala Ser Leu Ala Val Ala Glu 
625                 630                 635                 640 


Ala Ser Leu Arg Phe Glu His Arg Asp Leu His Trp Gly Asn Val Leu 
                645                 650                 655     


Leu Lys Lys Thr Ser Leu Lys Lys Leu His Tyr Thr Leu Asn Gly Lys 
            660                 665                 670         


Ser Ser Thr Ile Pro Ser Cys Gly Leu Gln Val Ser Ile Ile Asp Tyr 
        675                 680                 685             


Thr Leu Ser Arg Leu Glu Arg Asp Gly Ile Val Val Phe Cys Asp Val 
    690                 695                 700                 


Ser Met Asp Glu Asp Leu Phe Thr Gly Asp Gly Asp Tyr Gln Phe Asp 
705                 710                 715                 720 


Ile Tyr Arg Leu Met Lys Lys Glu Asn Asn Asn Arg Trp Gly Glu Tyr 
                725                 730                 735     


His Pro Tyr Ser Asn Val Leu Trp Leu His Tyr Leu Thr Asp Lys Met 
            740                 745                 750         


Leu Lys Gln Met Thr Phe Lys Thr Lys Cys Asn Thr Pro Ala Met Lys 
        755                 760                 765             


Gln Ile Lys Arg Lys Ile Gln Glu Phe His Arg Thr Met Leu Asn Phe 
    770                 775                 780                 


Ser Ser Ala Thr Asp Leu Leu Cys Gln His Ser Leu Phe Lys 
785                 790                 795             


<210> 5485
<211> 254
<212> PRT
<213> Homo sapiens

<400> 5485
Met Val Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu 
1               5                   10                  15      


Lys Glu Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala 
            20                  25                  30          


Leu Lys Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu 
        35                  40                  45              


Pro Leu Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn 
    50                  55                  60                  


Lys Ser Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val 
65                  70                  75                  80  


Ile Gln Pro Ile Val Lys Asp Cys Lys Glu Ala Asp Leu Ser Leu Tyr 
                85                  90                  95      


Asn Glu Phe Arg Leu Trp Lys Asp Glu Pro Thr Met Asp Arg Thr Cys 
            100                 105                 110         


Pro Phe Leu Asp Lys Ile Tyr Gln Glu Asp Ile Phe Pro Cys Leu Thr 
        115                 120                 125             


Phe Ser Lys Ser Glu Leu Ala Ser Ala Val Leu Glu Ala Val Glu Asn 
    130                 135                 140                 


Asn Thr Leu Ser Ile Glu Pro Val Gly Leu Gln Pro Ile Arg Phe Val 
145                 150                 155                 160 


Lys Ala Ser Ala Val Glu Cys Gly Gly Pro Lys Lys Cys Ala Leu Thr 
                165                 170                 175     


Gly Gln Ser Lys Ser Cys Lys His Arg Ile Lys Leu Gly Asp Ser Ser 
            180                 185                 190         


Asn Tyr Tyr Tyr Ile Ser Pro Phe Cys Arg Tyr Arg Ile Thr Ser Val 
        195                 200                 205             


Cys Asn Phe Phe Thr Tyr Ile Arg Tyr Ile Gln Gln Gly Leu Val Lys 
    210                 215                 220                 


Gln Gln Asp Val Asp Gln Met Phe Trp Glu Val Met Gln Leu Arg Lys 
225                 230                 235                 240 


Glu Met Ser Leu Ala Lys Leu Gly Tyr Phe Lys Glu Glu Leu 
                245                 250                 


<210> 5486
<211> 358
<212> PRT
<213> Homo sapiens

<400> 5486
Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe Thr Ala Lys Phe Pro 
1               5                   10                  15      


Leu Cys Met Val Phe His Ile Ile Asp Leu Leu Leu Cys Glu Gly Leu 
            20                  25                  30          


Asn Ile Ile Phe His Val Ala Leu Ala Leu Leu Lys Thr Ser Lys Glu 
        35                  40                  45              


Asp Leu Leu Gln Ala Asp Phe Glu Gly Ala Leu Lys Phe Phe Arg Val 
    50                  55                  60                  


Gln Leu Pro Lys Arg Tyr Arg Ala Glu Glu Asn Ala Arg Arg Leu Met 
65                  70                  75                  80  


Glu Gln Ala Cys Asn Ile Lys Val Pro Thr Lys Lys Leu Lys Lys Tyr 
                85                  90                  95      


Glu Lys Glu Tyr Gln Thr Met Arg Glu Ser Gln Leu Gln Gln Glu Asp 
            100                 105                 110         


Pro Met Asp Arg Tyr Lys Arg Glu Asn Arg Arg Leu Gln Glu Ala Ser 
        115                 120                 125             


Met Arg Leu Glu Gln Glu Asn Asp Asp Leu Ala His Glu Leu Val Thr 
    130                 135                 140                 


Ser Lys Ile Ala Leu Arg Asn Asp Leu Asp Gln Ala Glu Asp Lys Ala 
145                 150                 155                 160 


Asp Val Leu Asn Lys Glu Leu Leu Leu Thr Lys Gln Arg Leu Val Glu 
                165                 170                 175     


Thr Glu Glu Glu Lys Arg Lys Gln Glu Glu Glu Thr Ala Gln Leu Lys 
            180                 185                 190         


Glu Val Phe Arg Lys Gln Leu Glu Lys Ala Glu Tyr Glu Ile Lys Lys 
        195                 200                 205             


Thr Thr Ala Ile Ile Ala Glu Tyr Lys Gln Ile Cys Ser Gln Leu Ser 
    210                 215                 220                 


Thr Arg Leu Glu Lys Gln Gln Ala Ala Ser Lys Glu Glu Leu Glu Val 
225                 230                 235                 240 


Val Lys Gly Lys Met Met Ala Cys Lys His Cys Ser Asp Ile Phe Ser 
                245                 250                 255     


Lys Glu Gly Ala Leu Lys Leu Ala Ala Thr Gly Arg Glu Asp Gln Gly 
            260                 265                 270         


Ile Glu Thr Asp Asp Glu Lys Asp Ser Leu Lys Lys Gln Leu Arg Glu 
        275                 280                 285             


Met Glu Leu Glu Leu Ala Gln Thr Lys Leu Gln Leu Val Glu Ala Lys 
    290                 295                 300                 


Cys Lys Ile Gln Glu Leu Glu His Gln Arg Gly Ala Leu Met Asn Glu 
305                 310                 315                 320 


Ile Gln Ala Ala Lys Asn Ser Trp Phe Ser Lys Thr Leu Asn Ser Ile 
                325                 330                 335     


Lys Thr Ala Thr Gly Thr Gln Pro Leu Gln Pro Ala Pro Val Thr Gln 
            340                 345                 350         


Pro Pro Lys Glu Ser Thr 
        355             


<210> 5487
<211> 811
<212> PRT
<213> Homo sapiens

<400> 5487
Met Pro Leu Ser Ser Pro Asn Ala Ala Ala Thr Ala Ser Asp Met Asp 
1               5                   10                  15      


Lys Asn Ser Gly Ser Asn Ser Ser Ser Ala Ser Ser Gly Ser Ser Lys 
            20                  25                  30          


Gly Gln Gln Pro Pro Arg Ser Ala Ser Ala Gly Pro Ala Gly Glu Ser 
        35                  40                  45              


Lys Pro Lys Ser Asp Gly Lys Asn Ser Ser Gly Ser Lys Arg Tyr Asn 
    50                  55                  60                  


Arg Lys Arg Glu Leu Ser Tyr Pro Lys Asn Glu Ser Phe Asn Asn Gln 
65                  70                  75                  80  


Ser Arg Arg Ser Ser Ser Gln Lys Ser Lys Thr Phe Asn Lys Met Pro 
                85                  90                  95      


Pro Gln Arg Gly Gly Gly Ser Ser Lys Leu Phe Ser Ser Ser Phe Asn 
            100                 105                 110         


Gly Gly Arg Arg Asp Glu Val Ala Glu Ala Gln Arg Ala Glu Phe Ser 
        115                 120                 125             


Pro Ala Gln Phe Ser Gly Pro Lys Lys Ile Asn Leu Asn His Leu Leu 
    130                 135                 140                 


Asn Phe Thr Phe Glu Pro Arg Gly Gln Thr Gly His Phe Glu Gly Ser 
145                 150                 155                 160 


Gly His Gly Ser Trp Gly Lys Arg Asn Lys Trp Gly His Lys Pro Phe 
                165                 170                 175     


Asn Lys Glu Leu Phe Leu Gln Ala Asn Cys Gln Phe Val Val Ser Glu 
            180                 185                 190         


Asp Gln Asp Tyr Thr Ala His Phe Ala Asp Pro Asp Thr Leu Val Asn 
        195                 200                 205             


Trp Asp Phe Val Glu Gln Val Arg Ile Cys Ser His Glu Val Pro Ser 
    210                 215                 220                 


Cys Pro Ile Cys Leu Tyr Pro Pro Thr Ala Ala Lys Ile Thr Arg Cys 
225                 230                 235                 240 


Gly His Ile Phe Cys Trp Ala Cys Ile Leu His Tyr Leu Ser Leu Ser 
                245                 250                 255     


Glu Lys Thr Trp Ser Lys Cys Pro Ile Cys Tyr Ser Ser Val His Lys 
            260                 265                 270         


Lys Asp Leu Lys Ser Val Val Ala Thr Glu Ser His Gln Tyr Val Val 
        275                 280                 285             


Gly Asp Thr Ile Thr Met Gln Leu Met Lys Arg Glu Lys Gly Val Leu 
    290                 295                 300                 


Val Ala Leu Pro Lys Ser Lys Trp Met Asn Val Asp His Pro Ile His 
305                 310                 315                 320 


Leu Gly Asp Glu Gln His Ser Gln Tyr Ser Lys Leu Leu Leu Ala Ser 
                325                 330                 335     


Lys Glu Gln Val Leu His Arg Val Val Leu Glu Glu Lys Val Ala Leu 
            340                 345                 350         


Glu Gln Gln Leu Ala Glu Glu Lys His Thr Pro Glu Ser Cys Phe Ile 
        355                 360                 365             


Glu Ala Ala Ile Gln Glu Leu Lys Thr Arg Glu Glu Ala Leu Ser Gly 
    370                 375                 380                 


Leu Ala Gly Ser Arg Arg Glu Val Thr Gly Val Val Ala Ala Leu Glu 
385                 390                 395                 400 


Gln Leu Val Leu Met Ala Pro Leu Ala Lys Glu Ser Val Phe Gln Pro 
                405                 410                 415     


Arg Lys Gly Val Leu Glu Tyr Leu Ser Ala Phe Asp Glu Glu Thr Thr 
            420                 425                 430         


Glu Val Cys Ser Leu Asp Thr Pro Ser Arg Pro Leu Ala Leu Pro Leu 
        435                 440                 445             


Val Glu Glu Glu Glu Ala Val Ser Glu Pro Glu Pro Glu Gly Leu Pro 
    450                 455                 460                 


Glu Ala Cys Asp Asp Leu Glu Leu Ala Asp Asp Asn Leu Lys Glu Gly 
465                 470                 475                 480 


Thr Ile Cys Thr Glu Ser Ser Gln Gln Glu Pro Ile Thr Lys Ser Gly 
                485                 490                 495     


Phe Thr Arg Leu Ser Ser Ser Pro Cys Tyr Tyr Phe Tyr Gln Ala Glu 
            500                 505                 510         


Asp Gly Gln His Met Phe Leu His Pro Val Asn Val Arg Cys Leu Val 
        515                 520                 525             


Arg Glu Tyr Gly Ser Leu Glu Arg Ser Pro Glu Lys Ile Ser Ala Thr 
    530                 535                 540                 


Val Val Glu Ile Ala Gly Tyr Ser Met Ser Glu Asp Val Arg Gln Arg 
545                 550                 555                 560 


His Arg Tyr Leu Ser His Leu Pro Leu Thr Cys Glu Phe Ser Ile Cys 
                565                 570                 575     


Glu Leu Ala Leu Gln Pro Pro Val Val Ser Lys Glu Thr Leu Glu Met 
            580                 585                 590         


Phe Ser Asp Asp Ile Glu Lys Arg Lys Arg Gln Arg Gln Lys Lys Ala 
        595                 600                 605             


Arg Glu Glu Arg Arg Arg Glu Arg Arg Ile Glu Ile Glu Glu Asn Lys 
    610                 615                 620                 


Lys Gln Gly Lys Tyr Pro Glu Val His Ile Pro Leu Glu Asn Leu Gln 
625                 630                 635                 640 


Gln Phe Pro Ala Phe Asn Ser Tyr Thr Cys Ser Ser Asp Ser Ala Leu 
                645                 650                 655     


Gly Pro Thr Ser Thr Glu Gly His Gly Ala Leu Ser Ile Ser Pro Leu 
            660                 665                 670         


Ser Arg Ser Pro Gly Ser His Ala Asp Phe Leu Leu Thr Pro Leu Ser 
        675                 680                 685             


Pro Thr Ala Ser Gln Gly Ser Pro Ser Phe Cys Val Gly Ser Leu Glu 
    690                 695                 700                 


Glu Asp Ser Pro Phe Pro Ser Phe Ala Gln Met Leu Arg Val Gly Lys 
705                 710                 715                 720 


Ala Lys Ala Asp Val Trp Pro Lys Thr Ala Pro Lys Lys Asp Glu Asn 
                725                 730                 735     


Ser Leu Val Pro Pro Ala Pro Val Asp Ser Asp Gly Glu Ser Asp Asn 
            740                 745                 750         


Ser Asp Arg Val Pro Val Pro Ser Phe Gln Asn Ser Phe Ser Gln Ala 
        755                 760                 765             


Ile Glu Ala Ala Phe Met Lys Leu Asp Thr Pro Ala Thr Ser Asp Pro 
    770                 775                 780                 


Leu Ser Glu Glu Lys Gly Gly Lys Lys Arg Lys Lys Gln Lys Gln Lys 
785                 790                 795                 800 


Leu Leu Phe Ser Thr Ser Val Val His Thr Lys 
                805                 810     


<210> 5488
<211> 1941
<212> PRT
<213> Homo sapiens

<400> 5488
Met Lys Thr Ser Asp Leu Val Pro Ser Phe Gly Tyr Phe Ile Arg Ser 
1               5                   10                  15      


Pro Glu Lys Arg Glu Pro Ile Ala Leu Ile Arg Lys Ser Asp Val Ser 
            20                  25                  30          


Arg Gly Asn Leu Glu Lys Glu Met Ala His Leu Asn His Asp Leu Tyr 
        35                  40                  45              


Ser Gly Asp Leu Asn Glu Gln Ser Gln Ala Gln Leu Ser Glu Gly Ser 
    50                  55                  60                  


Ile Thr Leu Gln Val Glu Ala Val Glu Ser Thr Ser Gln Val Asp Glu 
65                  70                  75                  80  


Asn Asp Val Thr Leu Thr Ala Asp Lys Gly Lys Thr Glu Asp Thr Phe 
                85                  90                  95      


Phe Met Ser Asn Lys Pro Gln Arg Tyr Lys Asp Lys Leu Pro Asp Ser 
            100                 105                 110         


Gly Asp Ser Met Leu Arg Ile Ser Thr Ile Ala Ser Ala Ile Ala Glu 
        115                 120                 125             


Ala Ser Val Asn Thr Asp Pro Ser Gln Leu Ala Ala Met Ile Lys Ala 
    130                 135                 140                 


Leu Ser Asn Lys Thr Arg Asp Lys Thr Phe Gln Glu Asp Glu Lys Gln 
145                 150                 155                 160 


Lys Asp Tyr Ser His Val Arg His Phe Leu Pro Asn Asp Leu Glu Lys 
                165                 170                 175     


Ser Asn Gly Ser Asn Ala Leu Asp Met Glu Lys Tyr Leu Lys Lys Thr 
            180                 185                 190         


Glu Val Ser Arg Tyr Glu Ser Ala Leu Glu Asn Phe Ser Arg Ala Ser 
        195                 200                 205             


Met Ser Asp Thr Trp Asp Leu Ser Leu Pro Lys Glu Gln Thr Thr Gln 
    210                 215                 220                 


Asp Ile His Pro Val Asp Leu Ser Ala Thr Ser Val Ser Val Arg Ala 
225                 230                 235                 240 


Pro Glu Glu Asn Thr Ala Ala Ile Val Tyr Val Glu Asn Gly Glu Ser 
                245                 250                 255     


Glu Asn Gln Glu Ser Phe Arg Thr Ile Asn Ser Ser Asn Ser Val Thr 
            260                 265                 270         


Asn Arg Glu Asn Asn Ser Ala Val Val Asp Val Lys Thr Cys Ser Ile 
        275                 280                 285             


Asp Asn Lys Leu Gln Asp Val Gly Asn Asp Glu Lys Ala Thr Ser Ile 
    290                 295                 300                 


Ser Thr Pro Ser Asp Ser Tyr Ser Ser Val Arg Asn Pro Arg Ile Thr 
305                 310                 315                 320 


Ser Leu Cys Leu Leu Lys Asp Cys Glu Glu Ile Arg Asp Asn Arg Glu 
                325                 330                 335     


Asn Gln Arg Gln Asn Glu Cys Val Ser Glu Ile Ser Asn Ser Glu Lys 
            340                 345                 350         


His Val Thr Phe Glu Asn His Arg Ile Val Ser Pro Lys Asn Ser Asp 
        355                 360                 365             


Leu Lys Asn Thr Ser Pro Glu His Gly Gly Arg Gly Ser Glu Asp Glu 
    370                 375                 380                 


Gln Glu Ser Phe Arg Pro Ser Thr Ser Pro Leu Ser His Ser Ser Pro 
385                 390                 395                 400 


Ser Glu Ile Ser Gly Thr Ser Ser Ser Gly Cys Ala Leu Glu Ser Phe 
                405                 410                 415     


Gly Ser Ala Ala Gln Gln Gln Gln Pro Pro Cys Glu Gln Glu Leu Ser 
            420                 425                 430         


Pro Leu Val Cys Ser Pro Ala Gly Val Ser Arg Leu Thr Tyr Val Ser 
        435                 440                 445             


Glu Pro Glu Ser Ser Tyr Pro Thr Thr Ala Thr Asp Asp Ala Leu Glu 
    450                 455                 460                 


Asp Arg Lys Ser Asp Ile Thr Ser Glu Leu Ser Thr Thr Ile Ile Gln 
465                 470                 475                 480 


Gly Ser Pro Ala Ala Leu Glu Glu Arg Ala Met Glu Lys Leu Arg Glu 
                485                 490                 495     


Lys Val Pro Phe Gln Asn Arg Gly Lys Gly Thr Leu Ser Ser Ile Ile 
            500                 505                 510         


Gln Asn Asn Ser Asp Thr Arg Lys Ala Thr Glu Thr Thr Ser Leu Ser 
        515                 520                 525             


Ser Lys Pro Glu Tyr Val Lys Pro Asp Phe Arg Trp Ser Lys Asp Pro 
    530                 535                 540                 


Ser Ser Lys Ser Gly Asn Leu Leu Glu Thr Ser Glu Val Gly Trp Thr 
545                 550                 555                 560 


Ser Asn Pro Glu Glu Leu Asp Pro Ile Arg Leu Ala Leu Leu Gly Lys 
                565                 570                 575     


Ser Gly Leu Ser Cys Gln Val Gly Ser Ala Thr Ser His Pro Val Ser 
            580                 585                 590         


Cys Gln Glu Pro Ile Asp Glu Asp Gln Arg Ile Ser Pro Lys Asp Lys 
        595                 600                 605             


Ser Thr Ala Gly Arg Glu Phe Ser Gly Gln Val Ser His Gln Thr Thr 
    610                 615                 620                 


Ser Glu Asn Gln Cys Thr Pro Ile Pro Ser Ser Thr Val His Ser Ser 
625                 630                 635                 640 


Val Ala Asp Met Gln Asn Met Pro Ala Ala Val His Ala Leu Leu Thr 
                645                 650                 655     


Gln Pro Ser Leu Ser Ala Ala Pro Phe Ala Gln Arg Tyr Leu Gly Thr 
            660                 665                 670         


Leu Pro Ser Thr Gly Ser Thr Thr Leu Pro Gln Cys His Ala Gly Asn 
        675                 680                 685             


Ala Thr Val Cys Gly Phe Ser Gly Gly Leu Pro Tyr Pro Ala Val Ala 
    690                 695                 700                 


Gly Glu Pro Val Gln Asn Ser Val Ala Val Gly Ile Cys Leu Gly Ser 
705                 710                 715                 720 


Asn Ile Gly Ser Gly Trp Met Gly Thr Ser Ser Leu Cys Asn Pro Tyr 
                725                 730                 735     


Ser Asn Thr Leu Asn Gln Asn Leu Leu Ser Thr Thr Lys Pro Phe Pro 
            740                 745                 750         


Val Pro Ser Val Gly Thr Asn Cys Gly Ile Glu Pro Trp Asp Ser Gly 
        755                 760                 765             


Val Thr Ser Gly Leu Gly Ser Val Arg Val Pro Glu Glu Leu Lys Leu 
    770                 775                 780                 


Pro His Ala Cys Cys Val Gly Ile Ala Ser Gln Thr Leu Leu Ser Val 
785                 790                 795                 800 


Leu Asn Pro Thr Asp Arg Trp Leu Gln Val Ser Ile Gly Val Leu Ser 
                805                 810                 815     


Ile Ser Val Asn Gly Glu Lys Val Asp Leu Ser Thr Tyr Arg Cys Leu 
            820                 825                 830         


Val Phe Lys Asn Lys Ala Ile Ile Arg Pro His Ala Thr Glu Glu Ile 
        835                 840                 845             


Lys Val Leu Phe Ile Pro Ser Ser Pro Gly Val Phe Arg Cys Thr Phe 
    850                 855                 860                 


Ser Val Ala Ser Trp Pro Cys Ser Thr Asp Ala Glu Thr Ile Val Gln 
865                 870                 875                 880 


Ala Glu Ala Leu Ala Ser Thr Val Thr Leu Thr Ala Ile Ala Glu Ser 
                885                 890                 895     


Pro Val Ile Glu Val Glu Thr Glu Lys Lys Asp Val Leu Asp Phe Gly 
            900                 905                 910         


Asp Leu Thr Tyr Gly Gly Trp Lys Ala Leu Pro Leu Lys Leu Ile Asn 
        915                 920                 925             


Arg Thr His Ala Thr Val Pro Ile Arg Leu Ile Ile Asn Ala Asn Ala 
    930                 935                 940                 


Val Ala Trp Arg Cys Phe Thr Phe Ser Lys Glu Ser Val Arg Ala Pro 
945                 950                 955                 960 


Val Glu Val Ala Pro Cys Ala Asp Val Val Thr Arg Leu Ala Gly Pro 
                965                 970                 975     


Ser Val Val Asn His Met Met Pro Ala Ser Tyr Asp Gly Gln Asp Pro 
            980                 985                 990         


Glu Phe Leu Met Ile Trp Val Leu  Phe His Ser Pro Lys  Lys Gln Ile 
        995                 1000                 1005             


Ser Ser  Ser Asp Ile Leu Asp  Ser Ala Glu Glu Phe  Ser Ala Lys 
    1010                 1015                 1020             


Val Asp  Ile Glu Val Asp Ser  Pro Asn Pro Thr Pro  Val Leu Arg 
    1025                 1030                 1035             


Ser Val  Ser Leu Arg Ala Arg  Ala Gly Ile Ala Arg  Ile His Ala 
    1040                 1045                 1050             


Pro Arg  Asp Leu Gln Thr Met  His Phe Leu Ala Lys  Val Ala Ser 
    1055                 1060                 1065             


Ser Arg  Lys Gln His Leu Pro  Leu Lys Asn Ala Gly  Asn Ile Glu 
    1070                 1075                 1080             


Val Tyr  Leu Asp Ile Lys Val  Pro Glu Gln Gly Ser  His Phe Ser 
    1085                 1090                 1095             


Val Asp  Pro Lys Asn Leu Leu  Leu Lys Pro Gly Glu  Glu His Glu 
    1100                 1105                 1110             


Val Ile  Val Ser Phe Thr Pro  Lys Asp Pro Glu Ala  Cys Glu Glu 
    1115                 1120                 1125             


Arg Ile  Leu Lys Ile Phe Val  Gln Pro Phe Gly Pro  Gln Tyr Glu 
    1130                 1135                 1140             


Val Val  Leu Lys Gly Glu Val  Ile Ser Ser Gly Ser  Lys Pro Leu 
    1145                 1150                 1155             


Ser Pro  Gly Pro Cys Leu Asp  Ile Pro Ser Ile Leu  Ser Asn Lys 
    1160                 1165                 1170             


Gln Phe  Leu Ala Trp Gly Gly  Val Pro Leu Gly Arg  Thr Gln Leu 
    1175                 1180                 1185             


Gln Lys  Leu Ala Leu Arg Asn  Asn Ser Ala Ser Thr  Thr Gln His 
    1190                 1195                 1200             


Leu Arg  Leu Leu Ile Arg Gly  Gln Asp Gln Asp Cys  Phe Gln Leu 
    1205                 1210                 1215             


Gln Asn  Thr Phe Gly Ser Glu  Gln Arg Leu Thr Ser  Asn Cys Glu 
    1220                 1225                 1230             


Ile Arg  Ile His Pro Lys Glu  Asp Ile Phe Ile Ser  Val Leu Phe 
    1235                 1240                 1245             


Ala Pro  Thr Arg Leu Ser Cys  Met Leu Ala Arg Leu  Glu Ile Lys 
    1250                 1255                 1260             


Gln Leu  Gly Asn Arg Ser Gln  Pro Gly Ile Lys Phe  Thr Ile Pro 
    1265                 1270                 1275             


Leu Ser  Gly Tyr Gly Gly Thr  Ser Asn Leu Ile Leu  Glu Gly Val 
    1280                 1285                 1290             


Lys Lys  Leu Ser Asp Ser Tyr  Met Val Thr Val Asn  Gly Leu Val 
    1295                 1300                 1305             


Pro Gly  Lys Glu Ser Lys Ile  Val Phe Ser Val Arg  Asn Thr Gly 
    1310                 1315                 1320             


Ser Arg  Ala Ala Phe Val Lys  Ala Val Gly Phe Lys  Asp Ser Gln 
    1325                 1330                 1335             


Lys Lys  Val Leu Leu Asp Pro  Lys Val Leu Arg Ile  Phe Pro Asp 
    1340                 1345                 1350             


Lys Phe  Val Leu Lys Glu Arg  Thr Gln Glu Asn Val  Thr Leu Ile 
    1355                 1360                 1365             


Tyr Asn  Pro Ser Asp Arg Gly  Ile Asn Asn Lys Thr  Ala Thr Glu 
    1370                 1375                 1380             


Leu Ser  Thr Val Tyr Leu Phe  Gly Gly Asp Glu Ile  Ser Arg Gln 
    1385                 1390                 1395             


Gln Tyr  Arg Arg Ala Leu Leu  His Lys Pro Glu Met  Ile Lys Gln 
    1400                 1405                 1410             


Ile Leu  Pro Glu His Ser Val  Leu Gln Asn Ile Asn  Phe Val Glu 
    1415                 1420                 1425             


Ala Phe  Gln Asp Glu Leu Leu  Val Thr Glu Val Tyr  Asp Leu Pro 
    1430                 1435                 1440             


Gln Arg  Pro Asn Asp Val Gln  Leu Phe Tyr Gly Ser  Met Cys Lys 
    1445                 1450                 1455             


Ile Ile  Leu Ser Val Ile Gly  Glu Phe Arg Asp Cys  Ile Ser Ser 
    1460                 1465                 1470             


Arg Glu  Phe Leu Gln Pro Ser  Ser Lys Ala Ser Leu  Glu Ser Thr 
    1475                 1480                 1485             


Ser Asp  Leu Gly Ala Ser Gly  Lys His Gly Gly Asn  Val Ser Leu 
    1490                 1495                 1500             


Asp Val  Leu Pro Val Lys Gly  Pro Gln Gly Ser Pro  Leu Leu Ser 
    1505                 1510                 1515             


Arg Ala  Ala Arg Pro Pro Leu  Asp Gln Leu Ala Ser  Glu Glu Pro 
    1520                 1525                 1530             


Trp Thr  Val Leu Pro Glu His  Leu Ile Leu Val Ala  Pro Ser Pro 
    1535                 1540                 1545             


Cys Asp  Met Ala Lys Thr Gly  Arg Phe Gln Ile Val  Asn Asn Ser 
    1550                 1555                 1560             


Val Arg  Leu Leu Arg Phe Glu  Leu Cys Trp Pro Ala  His Cys Leu 
    1565                 1570                 1575             


Thr Val  Thr Pro Gln His Gly  Cys Val Ala Pro Glu  Ser Lys Leu 
    1580                 1585                 1590             


Gln Ile  Leu Val Ser Pro Asn  Ser Ser Leu Ser Thr  Lys Gln Ser 
    1595                 1600                 1605             


Met Phe  Pro Trp Ser Gly Leu  Ile Tyr Ile His Cys  Asp Asp Gly 
    1610                 1615                 1620             


Gln Lys  Lys Ile Val Lys Val  Gln Ile Arg Glu Asp  Leu Thr Gln 
    1625                 1630                 1635             


Val Glu  Leu Leu Thr Arg Leu  Thr Ser Lys Pro Phe  Gly Ile Leu 
    1640                 1645                 1650             


Ser Pro  Val Ser Glu Pro Ser  Val Ser His Leu Val  Lys Pro Met 
    1655                 1660                 1665             


Thr Lys  Pro Pro Ser Thr Lys  Val Glu Ile Arg Asn  Lys Ser Ile 
    1670                 1675                 1680             


Thr Phe  Pro Thr Thr Glu Pro  Gly Glu Thr Ser Glu  Ser Cys Leu 
    1685                 1690                 1695             


Glu Leu  Glu Asn His Gly Thr  Thr Asp Val Lys Trp  His Leu Ser 
    1700                 1705                 1710             


Ser Leu  Ala Pro Pro Tyr Val  Lys Gly Val Asp Glu  Ser Gly Asp 
    1715                 1720                 1725             


Val Phe  Arg Ala Thr Tyr Ala  Ala Phe Arg Cys Ser  Pro Ile Ser 
    1730                 1735                 1740             


Gly Leu  Leu Glu Ser His Gly  Ile Gln Lys Val Ser  Ile Thr Phe 
    1745                 1750                 1755             


Leu Pro  Arg Gly Arg Gly Asp  Tyr Ala Gln Phe Trp  Asp Val Glu 
    1760                 1765                 1770             


Cys His  Pro Leu Lys Glu Pro  His Met Lys His Thr  Leu Arg Phe 
    1775                 1780                 1785             


Gln Leu  Ser Gly Gln Ser Ile  Glu Ala Glu Asn Glu  Pro Glu Asn 
    1790                 1795                 1800             


Ala Cys  Leu Ser Thr Asp Ser  Leu Ile Lys Ile Asp  His Leu Val 
    1805                 1810                 1815             


Lys Pro  Arg Arg Gln Ala Val  Ser Glu Ala Ser Ala  Arg Ile Pro 
    1820                 1825                 1830             


Glu Gln  Leu Asp Val Thr Ala  Arg Gly Val Tyr Ala  Pro Glu Asp 
    1835                 1840                 1845             


Val Tyr  Arg Phe Arg Pro Thr  Ser Val Gly Glu Ser  Arg Thr Leu 
    1850                 1855                 1860             


Lys Val  Asn Leu Arg Asn Asn  Ser Phe Ile Thr His  Ser Leu Lys 
    1865                 1870                 1875             


Phe Leu  Ser Pro Arg Glu Pro  Phe Tyr Val Lys His  Ser Lys Tyr 
    1880                 1885                 1890             


Ser Leu  Arg Ala Gln His Tyr  Ile Asn Met Pro Val  Gln Phe Lys 
    1895                 1900                 1905             


Pro Lys  Ser Ala Gly Lys Phe  Glu Ala Leu Leu Val  Ile Gln Thr 
    1910                 1915                 1920             


Asp Glu  Gly Lys Ser Ile Ala  Ile Arg Leu Ile Gly  Glu Ala Leu 
    1925                 1930                 1935             


Gly Lys  Asn 
    1940     


<210> 5489
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 5489
Met Ala Pro Gly Cys Lys Thr Glu Leu Arg Ser Val Thr Asn Gly Gln 
1               5                   10                  15      


Ser Asn Gln Pro Ser Asn Glu Gly Asp Ala Ile Lys Val Phe Val Arg 
            20                  25                  30          


Ile Arg Pro Pro Ala Glu Arg Ser Gly Ser Ala Asp Gly Glu Gln Asn 
        35                  40                  45              


Leu Cys Leu Ser Val Leu Ser Ser Thr Ser Leu Arg Leu His Ser Asn 
    50                  55                  60                  


Pro Glu Pro Lys Thr Phe Thr Phe Asp His Val Ala Asp Val Asp Thr 
65                  70                  75                  80  


Thr Gln Glu Ser Val Phe Ala Thr Val Ala Lys Ser Ile Val Glu Ser 
                85                  90                  95      


Cys Met Ser Gly Tyr Asn Gly Thr Ile Phe Ala Tyr Gly Gln Thr Gly 
            100                 105                 110         


Ser Gly Lys Thr Phe Thr Met Met Gly Pro Ser Glu Ser Asp Asn Phe 
        115                 120                 125             


Ser His Asn Leu Arg Gly Val Ile Pro Arg Ser Phe Glu Tyr Leu Phe 
    130                 135                 140                 


Ser Leu Ile Asp Arg Glu Lys Glu Lys Ala Gly Ala Gly Lys Ser Phe 
145                 150                 155                 160 


Leu Cys Lys Cys Ser Phe Ile Glu Ile Tyr Asn Glu Gln Ile Tyr Asp 
                165                 170                 175     


Leu Leu Asp Ser Ala Ser Ala Gly Leu Tyr Leu Arg Glu His Ile Lys 
            180                 185                 190         


Lys Gly Val Phe Val Val Gly Ala Val Glu Gln Val Val Thr Ser Ala 
        195                 200                 205             


Ala Glu Ala Tyr Gln Val Leu Ser Gly Gly Trp Arg Asn Arg Arg Val 
    210                 215                 220                 


Ala Ser Thr Ser Met Asn Arg Glu Ser Ser Arg Ser His Ala Val Phe 
225                 230                 235                 240 


Thr Ile Thr Ile Glu Ser Met Glu Lys Ser Asn Glu Ile Val Asn Ile 
                245                 250                 255     


Arg Thr Ser Leu Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln 
            260                 265                 270         


Lys Asp Thr His Ala Glu Gly Met Arg Leu Lys Glu Ala Gly Asn Ile 
        275                 280                 285             


Asn Arg Ser Leu Ser Cys Leu Gly Gln Val Ile Thr Ala Leu Val Asp 
    290                 295                 300                 


Val Gly Asn Gly Lys Gln Arg His Val Cys Tyr Arg Asp Ser Lys Leu 
305                 310                 315                 320 


Thr Phe Leu Leu Arg Asp Ser Leu Gly Gly Asn Ala Lys Thr Ala Ile 
                325                 330                 335     


Ile Ala Asn Val His Pro Gly Ser Arg Cys Phe Gly Glu Thr Leu Ser 
            340                 345                 350         


Thr Leu Asn Phe Ala Gln Arg Ala Lys Leu Ile Lys Asn Lys Ala Val 
        355                 360                 365             


Val Asn Glu Asp Thr Gln Gly Asn Val Ser Gln Leu Gln Ala Glu Val 
    370                 375                 380                 


Lys Arg Leu Lys Glu Gln Leu Ala Glu Leu Ala Ser Gly Gln Thr Pro 
385                 390                 395                 400 


Pro Glu Ser Phe Leu Thr Arg Asp Lys Lys Lys Thr Asn Tyr Met Glu 
                405                 410                 415     


Tyr Phe Gln Glu Ala Met Leu Phe Phe Lys Lys Ser Glu Gln Glu Lys 
            420                 425                 430         


Lys Ser Leu Ile Glu Lys Val Thr Gln Leu Glu Asp Leu Thr Leu Lys 
        435                 440                 445             


Lys Glu Lys Phe Ile Gln Ser Asn Lys Met Ile Val Lys Phe Arg Glu 
    450                 455                 460                 


Asp Gln Ile Ile Arg Leu Glu Lys Leu His Lys Glu Ser Arg Gly Gly 
465                 470                 475                 480 


Phe Leu Pro Glu Glu Gln Asp Arg Leu Leu Ser Glu Leu Arg Asn Glu 
                485                 490                 495     


Ile Gln Thr Leu Arg Glu Gln Ile Glu His His Pro Arg Val Ala Lys 
            500                 505                 510         


Tyr Ala Met Glu Asn His Ser Leu Arg Glu Glu Asn Arg Arg Leu Arg 
        515                 520                 525             


Leu Leu Glu Pro Val Lys Arg Ala Gln Glu Met Asp Ala Gln Thr Ile 
    530                 535                 540                 


Ala Lys Leu Glu Lys Ala Phe Ser Glu Ile Ser Gly Met Glu Lys Ser 
545                 550                 555                 560 


Asp Lys Asn Gln Gln Gly Phe Ser Pro Lys Ala Gln Lys Glu Pro Cys 
                565                 570                 575     


Leu Phe Ala Asn Thr Glu Lys Leu Lys Ala Gln Leu Leu Gln Ile Gln 
            580                 585                 590         


Thr Glu Leu Asn Asn Ser Lys Gln Glu Tyr Glu Glu Phe Lys Glu Leu 
        595                 600                 605             


Thr Arg Lys Arg Gln Leu Glu Leu Glu Ser Glu Leu Gln Ser Leu Gln 
    610                 615                 620                 


Lys Ala Asn Leu Asn Leu Glu Asn Leu Leu Glu Ala Thr Lys Ala Cys 
625                 630                 635                 640 


Lys Arg Gln Glu Val Ser Gln Leu Asn Lys Ile His Ala Glu Thr Leu 
                645                 650                 655     


Lys Ile Ile Thr Thr Pro Thr Lys Ala Tyr Gln Leu His Ser Arg Pro 
            660                 665                 670         


Val Pro Lys Leu Ser Pro Glu Met Gly Ser Phe Gly Ser Leu Tyr Thr 
        675                 680                 685             


Gln Asn Ser Ser Ile Leu Asp Asn Asp Ile Leu Asn Glu Pro Val Pro 
    690                 695                 700                 


Pro Glu Met Asn Glu Gln Ala Phe Glu Ala Ile Ser Glu Glu Leu Arg 
705                 710                 715                 720 


Thr Val Gln Glu Gln Met Ser Ala Leu Gln Ala Lys Leu Asp Glu Glu 
                725                 730                 735     


Glu His Lys Asn Leu Lys Leu Gln Gln His Val Asp Lys Leu Glu His 
            740                 745                 750         


His Ser Thr Gln Met Gln Glu Leu Phe Ser Ser Glu Arg Ile Asp Trp 
        755                 760                 765             


Thr Lys Gln Gln Glu Glu Leu Leu Ser Gln Leu Asn Val Leu Glu Lys 
    770                 775                 780                 


Gln Leu Gln Glu Thr Gln Thr Lys Asn Asp Phe Leu Lys Ser Glu Val 
785                 790                 795                 800 


His Asp Leu Arg Val Val Leu His Ser Ala Asp Lys Glu Leu Ser Ser 
                805                 810                 815     


Val Lys Leu Glu Tyr Ser Ser Phe Lys Thr Asn Gln Glu Lys Glu Phe 
            820                 825                 830         


Asn Lys Leu Ser Glu Arg His Met His Val Gln Leu Gln Leu Asp Asn 
        835                 840                 845             


Leu Arg Leu Glu Asn Glu Lys Leu Leu Glu Ser Lys Ala Cys Leu Gln 
    850                 855                 860                 


Asp Ser Tyr Asp Asn Leu Gln Glu Ile Met Lys Phe Glu Ile Asp Gln 
865                 870                 875                 880 


Leu Ser Arg Asn Leu Gln Asn Phe Lys Lys Glu Asn Glu Thr Leu Lys 
                885                 890                 895     


Ser Asp Leu Asn Asn Leu Met Glu Leu Leu Glu Ala Glu Lys Glu Arg 
            900                 905                 910         


Asn Asn Lys Leu Ser Leu Gln Phe Glu Glu Asp Lys Glu Asn Ser Ser 
        915                 920                 925             


Lys Glu Ile Leu Lys Val Leu Glu Ala Val Arg Gln Glu Lys Gln Lys 
    930                 935                 940                 


Glu Thr Ala Lys Cys Glu Gln Gln Met Ala Lys Val Gln Lys Leu Glu 
945                 950                 955                 960 


Glu Ser Leu Leu Ala Thr Glu Lys Val Ile Ser Ser Leu Glu Lys Ser 
                965                 970                 975     


Arg Asp Ser Asp Lys Lys Val Val Ala Asp Leu Met Asn Gln Ile Gln 
            980                 985                 990         


Glu Leu Arg Thr Ser Val Cys Glu  Lys Thr Glu Thr Ile  Asp Thr Leu 
        995                 1000                 1005             


Lys Gln  Glu Leu Lys Asp Ile  Asn Cys Lys Tyr Asn  Ser Ala Leu 
    1010                 1015                 1020             


Val Asp  Arg Glu Glu Ser Arg  Val Leu Ile Lys Lys  Gln Glu Val 
    1025                 1030                 1035             


Asp Ile  Leu Asp Leu Lys Glu  Thr Leu Arg Leu Arg  Ile Leu Ser 
    1040                 1045                 1050             


Glu Asp  Ile Glu Arg Asp Met  Leu Cys Glu Asp Leu  Ala His Ala 
    1055                 1060                 1065             


Thr Glu  Gln Leu Asn Met Leu  Thr Glu Ala Ser Lys  Lys His Ser 
    1070                 1075                 1080             


Gly Leu  Leu Gln Ser Ala Gln  Glu Glu Leu Thr Lys  Lys Glu Ala 
    1085                 1090                 1095             


Leu Ile  Gln Glu Leu Gln His  Lys Leu Asn Gln Lys  Lys Glu Glu 
    1100                 1105                 1110             


Val Glu  Gln Lys Lys Asn Glu  Tyr Asn Phe Lys Met  Arg Gln Leu 
    1115                 1120                 1125             


Glu His  Val Met Asp Ser Ala  Ala Glu Asp Pro Gln  Ser Pro Lys 
    1130                 1135                 1140             


Thr Pro  Pro His Phe Gln Thr  His Leu Ala Lys Leu  Leu Glu Thr 
    1145                 1150                 1155             


Gln Glu  Gln Glu Ile Glu Asp  Gly Arg Ala Ser Lys  Thr Ser Leu 
    1160                 1165                 1170             


Glu His  Leu Val Thr Lys Leu  Asn Glu Asp Arg Glu  Val Lys Asn 
    1175                 1180                 1185             


Ala Glu  Ile Leu Arg Met Lys  Glu Gln Leu Arg Glu  Met Glu Asn 
    1190                 1195                 1200             


Leu Arg  Leu Glu Ser Gln Gln  Leu Ile Glu Lys Asn  Trp Leu Leu 
    1205                 1210                 1215             


Gln Gly  Gln Leu Asp Asp Ile  Lys Arg Gln Lys Glu  Asn Ser Asp 
    1220                 1225                 1230             


Gln Asn  His Pro Asp Asn Gln  Gln Leu Lys Asn Glu  Gln Glu Glu 
    1235                 1240                 1245             


Ser Ile  Lys Glu Arg Leu Ala  Lys Ser Lys Ile Val  Glu Glu Met 
    1250                 1255                 1260             


Leu Lys  Met Lys Ala Asp Leu  Glu Glu Val Gln Ser  Ala Leu Tyr 
    1265                 1270                 1275             


Asn Lys  Glu Met Glu Cys Leu  Arg Met Thr Asp Glu  Val Glu Arg 
    1280                 1285                 1290             


Thr Gln  Thr Leu Glu Ser Lys  Ala Phe Gln Glu Lys  Glu Gln Leu 
    1295                 1300                 1305             


Arg Ser  Lys Leu Glu Glu Met  Tyr Glu Glu Arg Glu  Arg Thr Ser 
    1310                 1315                 1320             


Gln Glu  Met Glu Met Leu Arg  Lys Gln Val Glu Cys  Leu Ala Glu 
    1325                 1330                 1335             


Glu Asn  Gly Lys Leu Val Gly  His Gln Asn Leu His  Gln Lys Ile 
    1340                 1345                 1350             


Gln Tyr  Val Val Arg Leu Lys  Lys Glu Asn Val Arg  Leu Ala Glu 
    1355                 1360                 1365             


Glu Thr  Glu Lys Leu Arg Ala  Glu Asn Val Phe Leu  Lys Glu Lys 
    1370                 1375                 1380             


Lys Arg  Ser Glu Ser 
    1385             


<210> 5490
<211> 1588
<212> PRT
<213> Homo sapiens

<400> 5490
Met Leu Pro Pro Lys His Leu Ser Ala Thr Lys Pro Lys Lys Ser Trp 
1               5                   10                  15      


Ala Pro Asn Leu Tyr Glu Leu Asp Ser Asp Leu Thr Lys Glu Pro Asp 
            20                  25                  30          


Val Ile Ile Gly Glu Gly Pro Thr Asp Ser Glu Phe Phe His Gln Arg 
        35                  40                  45              


Phe Arg Asn Leu Ile Tyr Val Glu Phe Val Gly Pro Arg Lys Thr Leu 
    50                  55                  60                  


Ile Lys Leu Arg Asn Leu Cys Leu Asp Trp Leu Gln Pro Glu Thr Arg 
65                  70                  75                  80  


Thr Lys Glu Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr 
                85                  90                  95      


Ile Ile Pro Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu 
            100                 105                 110         


Asn Cys Glu Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr 
        115                 120                 125             


Gln Pro Glu Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met 
    130                 135                 140                 


Thr Arg Asn Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe 
145                 150                 155                 160 


Ser Asp Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu Pro 
                165                 170                 175     


Arg Asp Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro Pro 
            180                 185                 190         


Arg Asp Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met Asp 
        195                 200                 205             


Arg Glu Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln Asp 
    210                 215                 220                 


Ala Glu Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys Pro 
225                 230                 235                 240 


His Asn Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu Ser 
                245                 250                 255     


Leu Val Gln Leu Ala Glu Asp Asp Gly His Ser His Met Thr Gln Gly 
            260                 265                 270         


His Ser Ser Arg Ser Lys Arg Ser Ala Tyr Pro Ser Thr Ser Arg Gly 
        275                 280                 285             


Leu Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His Arg Arg Gly Ile 
    290                 295                 300                 


Cys Glu Asp Glu Ser Ser His Gly Val Ile Met Glu Lys Phe Ile Lys 
305                 310                 315                 320 


Asp Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg Glu Ser Ser Asp 
                325                 330                 335     


Arg Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn Trp Lys Asp Ile 
            340                 345                 350         


Ser Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg Val Tyr Glu Gly 
        355                 360                 365             


Asn Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr Leu Val Ser Arg 
    370                 375                 380                 


Lys Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe Asp Thr Asp Gly 
385                 390                 395                 400 


Lys Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg Lys Lys Pro Phe 
                405                 410                 415     


Glu Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val Ser Ser Leu Ser 
            420                 425                 430         


Ser Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro Ile Asp Phe Gly 
        435                 440                 445             


Ala Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser Phe Ser Val Ile 
    450                 455                 460                 


Ser Glu Phe Val Glu His Gln Ile Met His Thr Arg Glu Asn Leu Tyr 
465                 470                 475                 480 


Glu Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val Ser Glu Val Gln 
                485                 490                 495     


Lys Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys Asp Cys Gly Glu 
            500                 505                 510         


Thr Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg Lys Ile His Ala 
        515                 520                 525             


Arg Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys Glu Glu Ala Phe 
    530                 535                 540                 


Met Pro Ser Pro Thr Phe Ser Glu Leu Gln Lys Ile Tyr Gly Lys Asp 
545                 550                 555                 560 


Lys Phe Tyr Glu Cys Arg Val Cys Lys Glu Thr Phe Leu His Ser Ser 
                565                 570                 575     


Ala Leu Ile Glu His Gln Lys Ile His Phe Gly Asp Asp Lys Asp Asn 
            580                 585                 590         


Glu Arg Glu His Glu Arg Glu Arg Glu Arg Glu Arg Gly Glu Thr Phe 
        595                 600                 605             


Arg Pro Ser Pro Ala Leu Asn Glu Phe Gln Lys Met Tyr Gly Lys Glu 
    610                 615                 620                 


Lys Met Tyr Glu Cys Lys Val Cys Gly Glu Thr Phe Leu His Ser Ser 
625                 630                 635                 640 


Ser Leu Lys Glu His Gln Lys Ile His Thr Arg Gly Asn Pro Phe Glu 
                645                 650                 655     


Asn Lys Gly Lys Val Cys Glu Glu Thr Phe Ile Pro Gly Gln Ser Leu 
            660                 665                 670         


Lys Arg Arg Gln Lys Thr Tyr Asn Lys Glu Lys Leu Cys Asp Phe Thr 
        675                 680                 685             


Asp Gly Arg Asp Ala Phe Met Gln Ser Ser Glu Leu Ser Glu His Gln 
    690                 695                 700                 


Lys Ile His Ser Arg Lys Asn Leu Phe Glu Gly Arg Gly Tyr Glu Lys 
705                 710                 715                 720 


Ser Val Ile His Ser Gly Pro Phe Thr Glu Ser Gln Lys Ser His Thr 
                725                 730                 735     


Ile Thr Arg Pro Leu Glu Ser Asp Glu Asp Glu Lys Ala Phe Thr Ile 
            740                 745                 750         


Ser Ser Asn Pro Tyr Glu Asn Gln Lys Ile Pro Thr Lys Glu Asn Val 
        755                 760                 765             


Tyr Glu Ala Lys Ser Tyr Glu Arg Ser Val Ile His Ser Leu Ala Ser 
    770                 775                 780                 


Val Glu Ala Gln Lys Ser His Ser Val Ala Gly Pro Ser Lys Pro Lys 
785                 790                 795                 800 


Val Met Ala Glu Ser Thr Ile Gln Ser Phe Asp Ala Ile Asn His Gln 
                805                 810                 815     


Arg Val Arg Ala Gly Gly Asn Thr Ser Glu Gly Arg Glu Tyr Ser Arg 
            820                 825                 830         


Ser Val Ile His Ser Leu Val Ala Ser Lys Pro Pro Arg Ser His Asn 
        835                 840                 845             


Gly Asn Glu Leu Val Glu Ser Asn Glu Lys Gly Glu Ser Ser Ile Tyr 
    850                 855                 860                 


Ile Ser Asp Leu Asn Asp Lys Arg Gln Lys Ile Pro Ala Arg Glu Asn 
865                 870                 875                 880 


Pro Cys Glu Gly Gly Ser Lys Asn Arg Asn Tyr Glu Asp Ser Val Ile 
                885                 890                 895     


Gln Ser Val Phe Arg Ala Lys Pro Gln Lys Ser Val Pro Gly Glu Gly 
            900                 905                 910         


Ser Gly Glu Phe Lys Lys Asp Gly Glu Phe Ser Val Pro Ser Ser Asn 
        915                 920                 925             


Val Arg Glu Tyr Gln Lys Ala Arg Ala Lys Lys Lys Tyr Ile Glu His 
    930                 935                 940                 


Arg Ser Asn Glu Thr Ser Val Ile His Ser Leu Pro Phe Gly Glu Gln 
945                 950                 955                 960 


Thr Phe Arg Pro Arg Gly Met Leu Tyr Glu Cys Gln Glu Cys Gly Glu 
                965                 970                 975     


Cys Phe Ala His Ser Ser Asp Leu Thr Glu His Gln Lys Ile His Asp 
            980                 985                 990         


Arg Glu Lys Pro Ser Gly Ser Arg  Asn Tyr Glu Trp Ser  Val Ile Arg 
        995                 1000                 1005             


Ser Leu  Ala Pro Thr Asp Pro  Gln Thr Ser Tyr Ala  Gln Glu Gln 
    1010                 1015                 1020             


Tyr Ala  Lys Glu Gln Ala Arg  Asn Lys Cys Lys Asp  Phe Arg Gln 
    1025                 1030                 1035             


Phe Phe  Ala Thr Ser Glu Asp  Leu Asn Thr Asn Gln  Lys Ile Tyr 
    1040                 1045                 1050             


Asp Gln  Glu Lys Ser His Gly  Glu Glu Ser Gln Gly  Glu Asn Thr 
    1055                 1060                 1065             


Asp Gly  Glu Glu Thr His Ser  Glu Glu Thr His Gly  Gln Glu Thr 
    1070                 1075                 1080             


Ile Glu  Asp Pro Val Ile Gln  Gly Ser Asp Met Glu  Asp Pro Gln 
    1085                 1090                 1095             


Lys Asp  Asp Pro Asp Asp Lys  Ile Tyr Glu Cys Glu  Asp Cys Gly 
    1100                 1105                 1110             


Leu Gly  Phe Val Asp Leu Thr  Asp Leu Thr Asp His  Gln Lys Val 
    1115                 1120                 1125             


His Ser  Arg Lys Cys Leu Val  Asp Ser Arg Glu Tyr  Thr His Ser 
    1130                 1135                 1140             


Val Ile  His Thr His Ser Ile  Ser Glu Tyr Gln Arg  Asp Tyr Thr 
    1145                 1150                 1155             


Gly Glu  Gln Leu Tyr Glu Cys  Pro Lys Cys Gly Glu  Ser Phe Ile 
    1160                 1165                 1170             


His Ser  Ser Phe Leu Phe Glu  His Gln Arg Ile His  Glu Gln Asp 
    1175                 1180                 1185             


Gln Leu  Tyr Ser Met Lys Gly  Cys Asp Asp Gly Phe  Ile Ala Leu 
    1190                 1195                 1200             


Leu Pro  Met Lys Pro Arg Arg  Asn Arg Ala Ala Glu  Arg Asn Pro 
    1205                 1210                 1215             


Ala Leu  Ala Gly Ser Ala Ile  Arg Cys Leu Leu Cys  Gly Gln Gly 
    1220                 1225                 1230             


Phe Ile  His Ser Ser Ala Leu  Asn Glu His Met Arg  Leu His Arg 
    1235                 1240                 1245             


Glu Asp  Asp Leu Leu Glu Gln  Ser Gln Met Ala Glu  Glu Ala Ile 
    1250                 1255                 1260             


Ile Pro  Gly Leu Ala Leu Thr  Glu Phe Gln Arg Ser  Gln Thr Glu 
    1265                 1270                 1275             


Glu Arg  Leu Phe Glu Cys Ala  Val Cys Gly Glu Ser  Phe Val Asn 
    1280                 1285                 1290             


Pro Ala  Glu Leu Ala Asp His  Val Thr Val His Lys  Asn Glu Pro 
    1295                 1300                 1305             


Tyr Glu  Tyr Gly Ser Ser Tyr  Thr His Thr Ser Phe  Leu Thr Glu 
    1310                 1315                 1320             


Pro Leu  Lys Gly Ala Ile Pro  Phe Tyr Glu Cys Lys  Asp Cys Gly 
    1325                 1330                 1335             


Lys Ser  Phe Ile His Ser Thr  Val Leu Thr Lys His  Lys Glu Leu 
    1340                 1345                 1350             


His Leu  Glu Glu Glu Glu Glu  Asp Glu Ala Ala Ala  Ala Ala Ala 
    1355                 1360                 1365             


Ala Ala  Ala Gln Glu Val Glu  Ala Asn Val His Val  Pro Gln Val 
    1370                 1375                 1380             


Val Leu  Arg Ile Gln Gly Leu  Asn Val Glu Ala Ala  Glu Pro Glu 
    1385                 1390                 1395             


Val Glu  Ala Ala Glu Pro Glu  Val Glu Ala Ala Glu  Pro Glu Val 
    1400                 1405                 1410             


Glu Ala  Ala Glu Pro Asn Gly  Glu Ala Glu Gly Pro  Asp Gly Glu 
    1415                 1420                 1425             


Ala Ala  Glu Pro Ile Gly Glu  Ala Gly Gln Pro Asn  Gly Glu Ala 
    1430                 1435                 1440             


Glu Gln  Pro Asn Gly Asp Ala  Asp Glu Pro Asp Gly  Ala Gly Ile 
    1445                 1450                 1455             


Glu Asp  Pro Glu Glu Arg Ala  Glu Glu Pro Glu Gly  Lys Ala Glu 
    1460                 1465                 1470             


Glu Pro  Glu Gly Asp Ala Asp  Glu Pro Asp Gly Val  Gly Ile Glu 
    1475                 1480                 1485             


Asp Pro  Glu Glu Gly Glu Asp  Gln Glu Ile Gln Val  Glu Glu Pro 
    1490                 1495                 1500             


Tyr Tyr  Asp Cys His Glu Cys  Thr Glu Thr Phe Thr  Ser Ser Thr 
    1505                 1510                 1515             


Ala Phe  Ser Glu His Leu Lys  Thr His Ala Ser Met  Ile Ile Phe 
    1520                 1525                 1530             


Glu Pro  Ala Asn Ala Phe Gly  Glu Cys Ser Gly Tyr  Ile Glu Arg 
    1535                 1540                 1545             


Ala Ser  Thr Ser Thr Gly Gly  Ala Asn Gln Ala Asp  Glu Lys Tyr 
    1550                 1555                 1560             


Phe Lys  Cys Asp Val Cys Gly  Gln Leu Phe Asn Asp  Arg Leu Ser 
    1565                 1570                 1575             


Leu Ala  Arg His Gln Asn Thr  His Thr Gly 
    1580                 1585             


<210> 5491
<211> 835
<212> PRT
<213> Homo sapiens

<400> 5491
Met Gly Asn Tyr Lys Ser Arg Pro Thr Gln Thr Cys Thr Asp Glu Trp 
1               5                   10                  15      


Lys Lys Lys Val Ser Glu Ser Tyr Val Ile Thr Ile Glu Arg Leu Glu 
            20                  25                  30          


Asp Asp Leu Gln Ile Lys Glu Lys Glu Leu Thr Glu Leu Arg Asn Ile 
        35                  40                  45              


Phe Gly Ser Asp Glu Ala Phe Ser Lys Val Asn Leu Asn Tyr Arg Thr 
    50                  55                  60                  


Glu Asn Gly Leu Ser Leu Leu His Leu Cys Cys Ile Cys Gly Gly Lys 
65                  70                  75                  80  


Lys Ser His Ile Arg Thr Leu Met Leu Lys Gly Leu Arg Pro Ser Arg 
                85                  90                  95      


Leu Thr Arg Asn Gly Phe Thr Ala Leu His Leu Ala Val Tyr Lys Asp 
            100                 105                 110         


Asn Ala Glu Leu Ile Thr Ser Leu Leu His Ser Gly Ala Asp Ile Gln 
        115                 120                 125             


Gln Val Gly Tyr Gly Gly Leu Thr Ala Leu His Ile Ala Thr Ile Ala 
    130                 135                 140                 


Gly His Leu Glu Ala Ala Asp Val Leu Leu Gln His Gly Ala Asn Val 
145                 150                 155                 160 


Asn Ile Gln Asp Ala Val Phe Phe Thr Pro Leu His Ile Ala Ala Tyr 
                165                 170                 175     


Tyr Gly His Glu Gln Val Thr Arg Leu Leu Leu Lys Phe Gly Ala Asp 
            180                 185                 190         


Val Asn Val Ser Gly Glu Val Gly Asp Arg Pro Leu His Leu Ala Ser 
        195                 200                 205             


Ala Lys Gly Phe Leu Asn Ile Ala Lys Leu Leu Met Glu Glu Gly Ser 
    210                 215                 220                 


Lys Ala Asp Val Asn Ala Gln Asp Asn Glu Asp His Val Pro Leu His 
225                 230                 235                 240 


Phe Cys Ser Arg Phe Gly His His Asp Ile Val Lys Tyr Leu Leu Gln 
                245                 250                 255     


Ser Asp Leu Glu Val Gln Pro His Val Val Asn Ile Tyr Gly Asp Thr 
            260                 265                 270         


Pro Leu His Leu Ala Cys Tyr Asn Gly Lys Phe Glu Val Ala Lys Glu 
        275                 280                 285             


Ile Ile Gln Ile Ser Gly Thr Glu Ser Leu Thr Lys Glu Asn Ile Phe 
    290                 295                 300                 


Ser Glu Thr Ala Phe His Ser Ala Cys Thr Tyr Gly Lys Ser Ile Asp 
305                 310                 315                 320 


Leu Val Lys Phe Leu Leu Asp Gln Asn Val Ile Asn Ile Asn His Gln 
                325                 330                 335     


Gly Arg Asp Gly His Thr Gly Leu His Ser Ala Cys Tyr His Gly His 
            340                 345                 350         


Ile Arg Leu Val Gln Phe Leu Leu Asp Asn Gly Ala Asp Met Asn Leu 
        355                 360                 365             


Val Ala Cys Asp Pro Ser Arg Ser Ser Gly Glu Lys Asp Glu Gln Thr 
    370                 375                 380                 


Cys Leu Met Trp Ala Tyr Glu Lys Gly His Asp Ala Ile Val Thr Leu 
385                 390                 395                 400 


Leu Lys His Tyr Lys Arg Pro Gln Asp Glu Leu Pro Cys Asn Glu Tyr 
                405                 410                 415     


Ser Gln Pro Gly Gly Asp Gly Ser Tyr Val Ser Val Pro Ser Pro Leu 
            420                 425                 430         


Gly Lys Ile Lys Ser Met Thr Lys Glu Lys Ala Asp Ile Leu Leu Leu 
        435                 440                 445             


Arg Ala Gly Leu Pro Ser His Phe His Leu Gln Leu Ser Glu Ile Glu 
    450                 455                 460                 


Phe His Glu Ile Ile Gly Ser Gly Ser Phe Gly Lys Val Tyr Lys Gly 
465                 470                 475                 480 


Arg Cys Arg Asn Lys Ile Val Ala Ile Lys Arg Tyr Arg Ala Asn Thr 
                485                 490                 495     


Tyr Cys Ser Lys Ser Asp Val Asp Met Phe Cys Arg Glu Val Ser Ile 
            500                 505                 510         


Leu Cys Gln Leu Asn His Pro Cys Val Ile Gln Phe Val Gly Ala Cys 
        515                 520                 525             


Leu Asn Asp Pro Ser Gln Phe Ala Ile Val Thr Gln Tyr Ile Ser Gly 
    530                 535                 540                 


Gly Ser Leu Phe Ser Leu Leu His Glu Gln Lys Arg Ile Leu Asp Leu 
545                 550                 555                 560 


Gln Ser Lys Leu Ile Ile Ala Val Asp Val Ala Lys Gly Met Glu Tyr 
                565                 570                 575     


Leu His Asn Leu Thr Gln Pro Ile Ile His Arg Asp Leu Asn Ser His 
            580                 585                 590         


Asn Ile Leu Leu Tyr Glu Asp Gly His Ala Val Val Ala Asp Phe Gly 
        595                 600                 605             


Glu Ser Arg Phe Leu Gln Ser Leu Asp Glu Asp Asn Met Thr Lys Gln 
    610                 615                 620                 


Pro Gly Asn Leu Arg Trp Met Ala Pro Glu Val Phe Thr Gln Cys Thr 
625                 630                 635                 640 


Arg Tyr Thr Ile Lys Ala Asp Val Phe Ser Tyr Ala Leu Cys Leu Trp 
                645                 650                 655     


Glu Ile Leu Thr Gly Glu Ile Pro Phe Ala His Leu Lys Pro Ala Ala 
            660                 665                 670         


Ala Ala Ala Asp Met Ala Tyr His His Ile Arg Pro Pro Ile Gly Tyr 
        675                 680                 685             


Ser Ile Pro Lys Pro Ile Ser Ser Leu Leu Ile Arg Gly Trp Asn Ala 
    690                 695                 700                 


Cys Pro Glu Gly Arg Pro Glu Phe Ser Glu Val Val Met Lys Leu Glu 
705                 710                 715                 720 


Glu Cys Leu Cys Asn Ile Glu Leu Met Ser Pro Ala Ser Ser Asn Ser 
                725                 730                 735     


Ser Gly Ser Leu Ser Pro Ser Ser Ser Ser Asp Cys Leu Val Asn Arg 
            740                 745                 750         


Gly Gly Pro Gly Arg Ser His Val Ala Ala Leu Arg Ser Arg Phe Glu 
        755                 760                 765             


Leu Glu Tyr Ala Leu Asn Ala Arg Ser Tyr Ala Ala Leu Ser Gln Ser 
    770                 775                 780                 


Ala Gly Gln Tyr Ser Ser Gln Gly Leu Ser Leu Glu Glu Met Lys Arg 
785                 790                 795                 800 


Ser Leu Gln Tyr Thr Pro Ile Asp Lys Tyr Gly Tyr Val Ser Asp Pro 
                805                 810                 815     


Met Ser Ser Met His Phe His Ser Cys Arg Asn Ser Ser Ser Phe Glu 
            820                 825                 830         


Asp Ser Ser 
        835 


<210> 5492
<211> 588
<212> PRT
<213> Homo sapiens

<400> 5492
Met Asn Thr Ser Ile Pro Tyr Gln Gln Asn Pro Tyr Asn Pro Arg Gly 
1               5                   10                  15      


Ser Ser Asn Val Ile Gln Cys Tyr Arg Cys Gly Asp Thr Cys Lys Gly 
            20                  25                  30          


Glu Val Val Arg Val His Asn Asn His Phe His Ile Arg Cys Phe Thr 
        35                  40                  45              


Cys Gln Val Cys Gly Cys Gly Leu Ala Gln Ser Gly Phe Phe Phe Lys 
    50                  55                  60                  


Asn Gln Glu Tyr Ile Cys Thr Gln Asp Tyr Gln Gln Leu Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys Asp Ser Cys Arg Asp Phe Ile Thr Gly Glu Val Ile Ser Ala 
                85                  90                  95      


Leu Gly Arg Thr Tyr His Pro Lys Cys Phe Val Cys Ser Leu Cys Arg 
            100                 105                 110         


Lys Pro Phe Pro Ile Gly Asp Lys Val Thr Phe Ser Gly Lys Glu Cys 
        115                 120                 125             


Val Cys Gln Thr Cys Ser Gln Ser Met Ala Ser Ser Lys Pro Ile Lys 
    130                 135                 140                 


Ile Arg Gly Pro Ser His Cys Ala Gly Cys Lys Glu Glu Ile Lys His 
145                 150                 155                 160 


Gly Gln Ser Leu Leu Ala Leu Asp Lys Gln Trp His Val Ser Cys Phe 
                165                 170                 175     


Lys Cys Gln Thr Cys Ser Val Ile Leu Thr Gly Glu Tyr Ile Ser Lys 
            180                 185                 190         


Asp Gly Val Pro Tyr Cys Glu Ser Asp Tyr His Ala Gln Phe Gly Ile 
        195                 200                 205             


Lys Cys Glu Thr Cys Asp Arg Tyr Ile Ser Gly Arg Val Leu Glu Ala 
    210                 215                 220                 


Gly Gly Lys His Tyr His Pro Thr Cys Ala Arg Cys Val Arg Cys His 
225                 230                 235                 240 


Gln Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Thr Gly Ser Glu Val 
                245                 250                 255     


Trp His Pro Ile Cys Lys Gln Ala Ala Arg Ala Glu Lys Lys Leu Lys 
            260                 265                 270         


His Arg Arg Thr Ser Glu Thr Ser Ile Ser Pro Pro Gly Ser Ser Ile 
        275                 280                 285             


Gly Ser Pro Asn Arg Val Ile Cys Asp Ile Tyr Glu Asn Leu Asp Leu 
    290                 295                 300                 


Arg Gln Arg Arg Ala Ser Ser Pro Gly Tyr Ile Asp Ser Pro Thr Tyr 
305                 310                 315                 320 


Ser Arg Gln Gly Met Ser Pro Thr Phe Ser Arg Ser Pro His His Tyr 
                325                 330                 335     


Tyr Arg Ser Ala Gly Asp Ser Asn Ile Tyr Arg Lys Pro Pro Ile Tyr 
            340                 345                 350         


Lys Arg His Gly Asp Leu Ser Thr Ala Thr Lys Ser Lys Thr Ser Glu 
        355                 360                 365             


Asp Ile Ser Gln Thr Ser Lys Tyr Ser Pro Ile Tyr Ser Pro Asp Pro 
    370                 375                 380                 


Tyr Tyr Ala Ser Glu Ser Glu Tyr Trp Thr Tyr His Gly Ser Pro Lys 
385                 390                 395                 400 


Val Pro Arg Ala Arg Arg Phe Ser Ser Gly Gly Glu Glu Asp Asp Phe 
                405                 410                 415     


Asp Arg Ser Met His Lys Leu Gln Ser Gly Ile Gly Arg Leu Ile Leu 
            420                 425                 430         


Lys Glu Glu Met Lys Ala Arg Ser Ser Ser Tyr Ala Asp Pro Trp Thr 
        435                 440                 445             


Pro Pro Arg Ser Ser Thr Ser Ser Arg Glu Ala Leu His Thr Ala Gly 
    450                 455                 460                 


Tyr Glu Met Ser Leu Asn Gly Ser Pro Arg Ser His Tyr Leu Ala Asp 
465                 470                 475                 480 


Ser Asp Pro Leu Ile Ser Lys Ser Ala Ser Leu Pro Ala Tyr Arg Arg 
                485                 490                 495     


Asn Gly Leu His Arg Thr Pro Ser Ala Asp Leu Phe His Tyr Asp Ser 
            500                 505                 510         


Met Asn Ala Val Asn Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr 
        515                 520                 525             


Glu Leu Leu Leu Val Thr Thr Arg Gly Arg Asn Arg Leu Pro Lys Asp 
    530                 535                 540                 


Val Asp Arg Thr Arg Leu Glu Arg His Leu Ser Gln Glu Glu Phe Tyr 
545                 550                 555                 560 


Gln Val Phe Gly Met Thr Ile Ser Glu Phe Asp Arg Leu Ala Leu Trp 
                565                 570                 575     


Lys Arg Asn Glu Leu Lys Lys Gln Ala Arg Leu Phe 
            580                 585             


<210> 5493
<211> 349
<212> PRT
<213> Homo sapiens

<400> 5493
Met Ala Ile Pro Ile Thr Val Leu Asp Cys Asp Leu Leu Leu Tyr Gly 
1               5                   10                  15      


Arg Gly His Arg Thr Leu Asp Arg Phe Lys Leu Asp Asp Val Thr Asp 
            20                  25                  30          


Glu Tyr Leu Met Ser Met Tyr Gly Phe Pro Arg Gln Phe Ile Tyr Tyr 
        35                  40                  45              


Leu Val Glu Leu Leu Gly Ala Asn Leu Ser Arg Pro Thr Gln Arg Ser 
    50                  55                  60                  


Arg Ala Ile Ser Pro Glu Thr Gln Val Leu Ala Ala Leu Gly Phe Tyr 
65                  70                  75                  80  


Thr Ser Gly Ser Phe Gln Thr Arg Met Gly Asp Ala Ile Gly Ile Ser 
                85                  90                  95      


Gln Ala Ser Met Ser Arg Cys Val Ala Asn Val Thr Glu Ala Leu Val 
            100                 105                 110         


Glu Arg Ala Ser Gln Phe Ile Arg Phe Pro Ala Asp Glu Ala Ser Ile 
        115                 120                 125             


Gln Ala Leu Lys Asp Glu Phe Tyr Gly Leu Ala Gly Met Pro Gly Val 
    130                 135                 140                 


Met Gly Val Val Asp Cys Ile His Val Ala Ile Lys Ala Pro Asn Ala 
145                 150                 155                 160 


Glu Asp Leu Ser Tyr Val Asn Arg Lys Gly Leu His Ser Leu Asn Cys 
                165                 170                 175     


Leu Met Val Cys Asp Ile Arg Gly Thr Leu Met Thr Val Glu Thr Asn 
            180                 185                 190         


Trp Pro Gly Ser Leu Gln Asp Cys Ala Val Leu Gln Gln Ser Ser Leu 
        195                 200                 205             


Ser Ser Gln Phe Glu Ala Gly Met His Lys Asp Ser Trp Leu Leu Gly 
    210                 215                 220                 


Asp Ser Ser Phe Phe Leu Arg Thr Trp Leu Met Thr Pro Leu His Ile 
225                 230                 235                 240 


Pro Glu Thr Pro Ala Glu Tyr Arg Tyr Asn Met Ala His Ser Ala Thr 
                245                 250                 255     


His Ser Val Ile Glu Lys Thr Phe Arg Thr Leu Cys Ser Arg Phe Arg 
            260                 265                 270         


Cys Leu Asp Gly Ser Lys Gly Ala Leu Gln Tyr Ser Pro Glu Lys Ser 
        275                 280                 285             


Ser His Ile Ile Leu Ala Cys Cys Val Leu His Asn Ile Ser Leu Glu 
    290                 295                 300                 


His Gly Met Asp Val Trp Ser Ser Pro Met Thr Gly Pro Met Glu Gln 
305                 310                 315                 320 


Pro Pro Glu Glu Glu Tyr Glu His Met Glu Ser Leu Asp Leu Glu Ala 
                325                 330                 335     


Asp Arg Ile Arg Gln Glu Leu Met Leu Thr His Phe Ser 
            340                 345                 


<210> 5494
<211> 597
<212> PRT
<213> Homo sapiens

<400> 5494
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Thr Glu Ser 
    50                  55                  60                  


Arg Gly Thr Asp Thr Glu Ser Ser Gly Glu Asp Lys Asp Ser Asp Ser 
65                  70                  75                  80  


Met Glu Asp Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His 
                85                  90                  95      


Asp Arg Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Gln Pro Arg Arg Arg Val Gln Arg Lys Arg Ala Asn Arg Asp Gln Asp 
        115                 120                 125             


Ser Ser Asp Asp Glu Arg Ala Leu Glu Asp Trp Val Ser Ser Glu Thr 
    130                 135                 140                 


Ser Ala Leu Pro Arg Pro Arg Trp Gln Ala Leu Pro Ala Leu Arg Glu 
145                 150                 155                 160 


Arg Glu Leu Gly Ser Ser Ala Arg Phe Val Tyr Glu Ala Cys Gly Ala 
                165                 170                 175     


Arg Val Phe Val Gln Arg Phe Arg Leu Gln His Gly Leu Glu Gly His 
            180                 185                 190         


Thr Gly Cys Val Asn Thr Leu His Phe Asn Gln Arg Gly Thr Trp Leu 
        195                 200                 205             


Ala Ser Gly Ser Asp Asp Leu Lys Val Val Val Trp Asp Trp Val Arg 
    210                 215                 220                 


Arg Gln Pro Val Leu Asp Phe Glu Ser Gly His Lys Ser Asn Val Phe 
225                 230                 235                 240 


Gln Ala Lys Phe Leu Pro Asn Ser Gly Asp Ser Thr Leu Ala Met Cys 
                245                 250                 255     


Ala Arg Asp Gly Gln Val Arg Val Ala Glu Leu Ser Ala Thr Gln Cys 
            260                 265                 270         


Cys Lys Asn Thr Lys Arg Val Ala Gln His Lys Gly Ala Ser His Lys 
        275                 280                 285             


Leu Ala Leu Glu Pro Asp Ser Pro Cys Thr Phe Leu Ser Ala Gly Glu 
    290                 295                 300                 


Asp Ala Val Val Phe Thr Ile Asp Leu Arg Gln Asp Arg Pro Ala Ser 
305                 310                 315                 320 


Lys Leu Val Val Thr Lys Glu Lys Glu Lys Lys Val Gly Leu Tyr Thr 
                325                 330                 335     


Ile Tyr Val Asn Pro Ala Asn Thr His Gln Phe Ala Val Gly Gly Arg 
            340                 345                 350         


Asp Gln Phe Val Arg Ile Tyr Asp Gln Arg Lys Ile Asp Glu Asn Glu 
        355                 360                 365             


Asn Asn Gly Val Leu Lys Lys Phe Cys Pro His His Leu Val Asn Ser 
    370                 375                 380                 


Glu Ser Lys Ala Asn Ile Thr Cys Leu Val Tyr Ser His Asp Gly Thr 
385                 390                 395                 400 


Glu Leu Leu Ala Ser Tyr Asn Asp Glu Asp Ile Tyr Leu Phe Asn Ser 
                405                 410                 415     


Ser His Ser Asp Gly Ala Gln Tyr Val Lys Arg Tyr Lys Gly His Arg 
            420                 425                 430         


Asn Asn Ala Thr Val Lys Gly Val Asn Phe Tyr Gly Pro Lys Ser Glu 
        435                 440                 445             


Phe Val Val Ser Gly Ser Asp Cys Gly His Ile Phe Leu Trp Glu Lys 
    450                 455                 460                 


Ser Ser Cys Gln Ile Ile Gln Phe Met Glu Gly Asp Lys Gly Gly Val 
465                 470                 475                 480 


Val Asn Cys Leu Glu Pro His Pro His Leu Pro Val Leu Ala Thr Ser 
                485                 490                 495     


Gly Leu Asp His Asp Val Lys Ile Trp Ala Pro Thr Ala Glu Ala Ser 
            500                 505                 510         


Thr Glu Leu Thr Gly Leu Lys Asp Val Ile Lys Lys Asn Lys Arg Glu 
        515                 520                 525             


Arg Asp Glu Asp Ser Leu His Gln Thr Asp Leu Phe Asp Ser His Met 
    530                 535                 540                 


Leu Trp Phe Leu Met His His Leu Arg Gln Arg Arg His His Arg Arg 
545                 550                 555                 560 


Trp Arg Glu Pro Gly Val Gly Ala Thr Asp Ala Asp Ser Asp Glu Ser 
                565                 570                 575     


Pro Ser Ser Ser Asp Thr Ser Asp Glu Glu Glu Gly Pro Asp Arg Val 
            580                 585                 590         


Gln Cys Met Pro Ser 
        595         


<210> 5495
<211> 310
<212> PRT
<213> Homo sapiens

<400> 5495
Met Ser Gln Gln Leu Lys Lys Arg Ala Lys Thr Arg His Gln Lys Gly 
1               5                   10                  15      


Leu Gly Gly Arg Ala Pro Ser Gly Ala Lys Pro Arg Gln Gly Lys Ser 
            20                  25                  30          


Ser Gln Asp Leu Gln Ala Glu Ile Glu Pro Val Ser Ala Val Trp Ala 
        35                  40                  45              


Leu Cys Asp Gly Tyr Val Cys Tyr Glu Pro Gly Pro Gln Ala Leu Gly 
    50                  55                  60                  


Gly Asp Asp Phe Ser Asp Cys Tyr Ile Glu Cys Val Ile Arg Gly Glu 
65                  70                  75                  80  


Phe Ser Gln Pro Ile Leu Glu Glu Asp Ser Leu Phe Glu Ser Leu Glu 
                85                  90                  95      


Tyr Leu Lys Lys Gly Ser Glu Gln Gln Leu Ser Gln Lys Val Phe Glu 
            100                 105                 110         


Ala Ser Ser Leu Glu Cys Ser Leu Glu Tyr Met Lys Lys Gly Val Lys 
        115                 120                 125             


Lys Glu Leu Pro Gln Lys Ile Val Gly Glu Asn Ser Leu Glu Tyr Ser 
    130                 135                 140                 


Glu Tyr Met Thr Gly Lys Lys Leu Pro Pro Gly Gly Ile Pro Gly Ile 
145                 150                 155                 160 


Asp Leu Ser Asp Pro Lys Gln Leu Ala Glu Phe Ala Arg Lys Lys Pro 
                165                 170                 175     


Pro Ile Asn Lys Glu Tyr Asp Ser Leu Ser Ala Ile Ala Cys Pro Gln 
            180                 185                 190         


Ser Gly Cys Thr Arg Lys Leu Arg Asn Arg Ala Ala Leu Arg Lys His 
        195                 200                 205             


Leu Leu Ile His Gly Pro Arg Asp His Val Cys Ala Glu Cys Gly Lys 
    210                 215                 220                 


Ala Phe Val Glu Ser Ser Lys Leu Lys Arg His Phe Leu Val His Thr 
225                 230                 235                 240 


Gly Glu Lys Pro Phe Arg Cys Thr Phe Glu Gly Cys Gly Lys Arg Phe 
                245                 250                 255     


Ser Leu Asp Phe Asn Leu Arg Thr His Val Arg Ile His Thr Gly Glu 
            260                 265                 270         


Lys Arg Phe Val Cys Pro Phe Gln Gly Cys Asn Arg Arg Phe Ile Gln 
        275                 280                 285             


Ser Asn Asn Leu Lys Ala His Ile Leu Thr His Ala Asn Thr Asn Lys 
    290                 295                 300                 


Asn Glu Gln Glu Gly Lys 
305                 310 


<210> 5496
<211> 382
<212> PRT
<213> Homo sapiens

<400> 5496
Met Leu Arg Trp Thr Val His Leu Glu Gly Gly Pro Arg Arg Val Asn 
1               5                   10                  15      


His Ala Ala Val Ala Val Gly His Arg Val Tyr Ser Phe Gly Gly Tyr 
            20                  25                  30          


Cys Ser Gly Glu Asp Tyr Glu Thr Leu Arg Gln Ile Asp Val His Ile 
        35                  40                  45              


Phe Asn Ala Val Ser Leu Arg Trp Thr Lys Leu Pro Pro Val Lys Ser 
    50                  55                  60                  


Ala Ile Arg Gly Gln Ala Pro Val Val Pro Tyr Met Arg Tyr Gly His 
65                  70                  75                  80  


Ser Thr Val Leu Ile Asp Asp Thr Val Leu Leu Trp Gly Gly Arg Asn 
                85                  90                  95      


Asp Thr Glu Gly Ala Cys Asn Val Leu Tyr Ala Phe Asp Val Asn Thr 
            100                 105                 110         


His Lys Trp Phe Thr Pro Arg Val Ser Gly Thr Val Pro Gly Ala Arg 
        115                 120                 125             


Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile Met Tyr Ile Phe Gly 
    130                 135                 140                 


Gly Tyr Glu Gln Gln Ala Asp Cys Phe Ser Asn Asp Ile His Lys Leu 
145                 150                 155                 160 


Asp Thr Ser Thr Met Thr Trp Thr Leu Ile Cys Thr Lys Gly Ser Pro 
                165                 170                 175     


Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met Leu Gly Ser His Met 
            180                 185                 190         


Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly Pro Phe His Ser Asn 
        195                 200                 205             


Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe Asp Thr Arg Thr Glu 
    210                 215                 220                 


Ala Trp Leu Asp Cys Pro Pro Thr Pro Val Leu Pro Glu Gly Arg Arg 
225                 230                 235                 240 


Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu Tyr Ile Phe Gly Gly 
                245                 250                 255     


Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp Leu Trp Lys Phe Asn 
            260                 265                 270         


Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro Lys Gly Lys Gly Pro 
        275                 280                 285             


Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val Gly Asp Lys Ile Val 
    290                 295                 300                 


Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu Gly Leu Gly Asp Glu 
305                 310                 315                 320 


Phe Asp Leu Ile Asp His Ser Asp Leu His Ile Leu Asp Phe Ser Pro 
                325                 330                 335     


Ser Leu Lys Thr Leu Cys Lys Leu Ala Val Ile Gln Tyr Asn Leu Asp 
            340                 345                 350         


Gln Ser Cys Leu Pro His Asp Ile Arg Trp Glu Leu Asn Ala Met Thr 
        355                 360                 365             


Thr Asn Ser Asn Ile Ser Arg Pro Ile Val Ser Ser His Gly 
    370                 375                 380         


<210> 5497
<211> 608
<212> PRT
<213> Homo sapiens

<400> 5497
Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Thr Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Thr Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Thr Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Thr Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg 
        115                 120                 125             


Gly His Thr Leu Glu Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln 
145                 150                 155                 160 


Asn Met Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile 
                165                 170                 175     


Leu Gln Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly 
            180                 185                 190         


Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg 
        195                 200                 205             


Lys Ile Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val 
    210                 215                 220                 


Leu Val Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly 
225                 230                 235                 240 


Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser 
                245                 250                 255     


Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr 
            260                 265                 270         


Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr 
        275                 280                 285             


Ile Gly Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met 
    290                 295                 300                 


Glu Gln Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly 
305                 310                 315                 320 


Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg 
                325                 330                 335     


Gln Pro Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser 
            340                 345                 350         


Val Lys Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His 
        355                 360                 365             


Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val 
    370                 375                 380                 


His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met 
385                 390                 395                 400 


Thr Val Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr 
                405                 410                 415     


Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp 
            420                 425                 430         


Thr Leu Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr 
        435                 440                 445             


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser 
    450                 455                 460                 


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr 
465                 470                 475                 480 


Pro Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met 
                485                 490                 495     


Trp Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
            500                 505                 510         


Gly Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
        515                 520                 525             


Ser Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val 
    530                 535                 540                 


Asn His Thr His Ser Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val 
545                 550                 555                 560 


Gln Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala 
                565                 570                 575     


His Tyr Ala Val Asn Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser 
            580                 585                 590         


Met Ala Ser Pro Met Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser 
        595                 600                 605             


<210> 5498
<211> 970
<212> PRT
<213> Homo sapiens

<400> 5498
Met Gln Ser Thr Asp Leu Gly Asn Lys Glu Ser Gly Lys Ile Trp His 
1               5                   10                  15      


Arg Lys Pro Ser Pro Ala Thr Arg Asp Gly Ile Ile Val Asn Ile Ile 
            20                  25                  30          


His Asn Thr Ser Asp Tyr His Pro Lys Val Leu Arg Phe Leu Asn Val 
        35                  40                  45              


Ala Phe Asp Gly Thr Gly Asp Cys Leu Ile Ala Gly Asp His Gln Gly 
    50                  55                  60                  


Asn Ile Tyr Val Phe Asp Leu His Gly Asn Arg Phe Asn Leu Val Gln 
65                  70                  75                  80  


Arg Thr Ala Gln Ala Cys Thr Ala Leu Ala Phe Asn Leu Arg Arg Lys 
                85                  90                  95      


Ser Glu Phe Leu Val Ala Leu Ala Asp Tyr Ser Ile Lys Cys Phe Asp 
            100                 105                 110         


Thr Val Thr Lys Glu Leu Val Ser Trp Met Arg Gly His Glu Ser Ser 
        115                 120                 125             


Val Phe Ser Ile Ser Val His Ala Ser Gly Lys Tyr Ala Ile Thr Thr 
    130                 135                 140                 


Ser Ser Asp Thr Ala Gln Leu Trp Asp Leu Asp Thr Phe Gln Arg Lys 
145                 150                 155                 160 


Arg Lys Leu Asn Ile Arg Gln Ser Val Gly Ile Gln Lys Val Phe Phe 
                165                 170                 175     


Leu Pro Leu Ser Asn Thr Ile Leu Ser Cys Phe Lys Asp Asn Ser Ile 
            180                 185                 190         


Phe Ala Trp Glu Cys Asp Thr Leu Phe Cys Lys Tyr Gln Leu Pro Ala 
        195                 200                 205             


Pro Pro Glu Ser Ser Ser Ile Leu Tyr Lys Val Phe Ala Val Thr Arg 
    210                 215                 220                 


Asp Gly Arg Ile Leu Ala Ala Gly Gly Lys Ser Asn His Leu His Leu 
225                 230                 235                 240 


Trp Cys Leu Glu Ala Arg Gln Leu Phe Arg Ile Ile Gln Met Pro Thr 
                245                 250                 255     


Lys Val Arg Ala Ile Arg His Leu Glu Phe Leu Pro Asp Ser Phe Asp 
            260                 265                 270         


Ala Gly Ser Asn Gln Val Leu Gly Val Leu Ser Gln Asp Gly Ile Met 
        275                 280                 285             


Arg Phe Ile Asn Met Gln Thr Cys Lys Leu Leu Phe Glu Ile Gly Ser 
    290                 295                 300                 


Leu Asp Glu Gly Ile Ser Ser Ser Ala Ile Ser Pro His Gly Arg Tyr 
305                 310                 315                 320 


Ile Ala Ser Ile Met Glu Asn Gly Ser Leu Asn Ile Tyr Ser Val Gln 
                325                 330                 335     


Ala Leu Thr Gln Glu Ile Asn Lys Pro Pro Pro Pro Leu Val Lys Val 
            340                 345                 350         


Ile Glu Asp Leu Pro Lys Asn Lys Leu Ser Ser Ser Asp Leu Lys Met 
        355                 360                 365             


Lys Val Thr Ser Gly Arg Val Gln Gln Pro Ala Lys Ser Arg Glu Ser 
    370                 375                 380                 


Lys Met Gln Thr Arg Ile Leu Lys Gln Asp Leu Thr Gly Asp Phe Glu 
385                 390                 395                 400 


Ser Lys Lys Asn Glu Leu Pro Asp Gly Leu Asn Lys Lys Arg Leu Gln 
                405                 410                 415     


Ile Leu Leu Lys Gly Tyr Gly Glu Tyr Pro Thr Lys Tyr Arg Met Phe 
            420                 425                 430         


Ile Trp Arg Ser Leu Leu Gln Leu Pro Glu Asn His Thr Ala Phe Ser 
        435                 440                 445             


Thr Leu Ile Asp Lys Gly Thr His Val Ala Phe Leu Asn Leu Gln Lys 
    450                 455                 460                 


Lys Tyr Pro Ile Lys Ser Arg Lys Leu Leu Arg Val Leu Gln Arg Thr 
465                 470                 475                 480 


Leu Ser Ala Leu Ala His Trp Ser Val Ile Phe Ser Asp Thr Pro Tyr 
                485                 490                 495     


Leu Pro Leu Leu Ala Phe Pro Phe Val Lys Leu Phe Gln Asn Asn Gln 
            500                 505                 510         


Leu Ile Cys Phe Glu Val Ile Ala Thr Leu Ile Ile Asn Trp Cys Gln 
        515                 520                 525             


His Trp Phe Glu Tyr Phe Pro Asn Pro Pro Ile Asn Ile Leu Ser Met 
    530                 535                 540                 


Ile Glu Asn Val Leu Ala Phe His Asp Lys Glu Leu Leu Gln His Phe 
545                 550                 555                 560 


Ile Asp His Asp Ile Thr Ser Gln Leu Tyr Ala Trp Pro Leu Leu Glu 
                565                 570                 575     


Thr Val Phe Ser Glu Val Leu Thr Arg Glu Glu Trp Leu Lys Leu Phe 
            580                 585                 590         


Asp Asn Ile Phe Ser Asn His Pro Ser Phe Leu Leu Met Thr Val Val 
        595                 600                 605             


Ala Tyr Asn Ile Cys Ser Arg Thr Pro Leu Leu Ser Cys Asn Leu Lys 
    610                 615                 620                 


Asp Asp Phe Glu Phe Phe Phe His His Arg Asn Asn Leu Asp Ile Asn 
625                 630                 635                 640 


Val Val Ile Arg Gln Val Tyr His Leu Met Glu Thr Thr Pro Thr Asp 
                645                 650                 655     


Ile His Pro Asp Ser Met Leu Asn Val Phe Val Ala Leu Thr Lys Gly 
            660                 665                 670         


Gln Tyr Pro Val Phe Asn Gln Tyr Pro Lys Phe Ile Val Asp Tyr Gln 
        675                 680                 685             


Thr Gln Glu Arg Glu Arg Ile Arg Asn Asp Glu Leu Asp Tyr Leu Arg 
    690                 695                 700                 


Glu Arg Gln Thr Val Glu Asp Met Gln Ala Lys Val Asp Gln Gln Arg 
705                 710                 715                 720 


Val Glu Asp Glu Ala Trp Tyr Gln Lys Gln Glu Leu Leu Arg Lys Ala 
                725                 730                 735     


Glu Glu Thr Arg Arg Glu Met Leu Leu Gln Glu Glu Glu Lys Met Ile 
            740                 745                 750         


Gln Gln Arg Gln Arg Leu Ala Ala Val Lys Arg Glu Leu Lys Val Lys 
        755                 760                 765             


Glu Met His Leu Gln Asp Ala Ala Arg Arg Arg Phe Leu Lys Leu Gln 
    770                 775                 780                 


Gln Asp Gln Gln Glu Met Glu Leu Arg Arg Leu Asp Asp Glu Ile Gly 
785                 790                 795                 800 


Arg Lys Asn Leu Thr Glu Asn Gln Glu Ala Leu Ala Lys Glu Met Arg 
                805                 810                 815     


Ala Asp Ala Asp Ala Tyr Arg Arg Lys Val Asp Leu Glu Glu His Met 
            820                 825                 830         


Phe His Lys Leu Ile Glu Ala Gly Glu Thr Gln Ser Gln Lys Thr Gln 
        835                 840                 845             


Lys Trp Lys Glu Ala Glu Gly Lys Glu Phe Arg Leu Arg Ser Ala Lys 
    850                 855                 860                 


Lys Ala Ser Ala Leu Ser Asp Ala Ser Arg Lys Trp Phe Leu Lys Gln 
865                 870                 875                 880 


Glu Ile Asn Ala Ala Val Glu His Ala Glu Asn Pro Cys His Lys Glu 
                885                 890                 895     


Glu Pro Arg Phe Gln Asn Glu Gln Asp Ser Ser Cys Leu Pro Arg Thr 
            900                 905                 910         


Ser Gln Leu Asn Asp Ser Ser Glu Met Asp Pro Ser Thr Gln Ile Ser 
        915                 920                 925             


Leu Asn Arg Arg Ala Val Glu Trp Asp Thr Thr Gly Gln Asn Leu Ile 
    930                 935                 940                 


Lys Lys Val Arg Asn Leu Arg Gln Arg Leu Thr Ala Arg Ala Arg His 
945                 950                 955                 960 


Arg Cys Gln Thr Pro His Leu Leu Ala Ala 
                965                 970 


<210> 5499
<211> 215
<212> PRT
<213> Homo sapiens

<400> 5499
Met Ser Cys Thr Ile Glu Lys Ala Leu Ala Asp Ala Lys Ala Leu Val 
1               5                   10                  15      


Glu Arg Leu Arg Asp His Asp Asp Ala Ala Glu Ser Leu Ile Glu Gln 
            20                  25                  30          


Thr Thr Ala Leu Asn Lys Arg Val Glu Ala Met Lys Gln Tyr Gln Glu 
        35                  40                  45              


Glu Ile Gln Glu Leu Asn Glu Val Ala Arg His Arg Pro Arg Ser Thr 
    50                  55                  60                  


Leu Val Met Gly Ile Gln Gln Glu Asn Arg Gln Ile Arg Glu Leu Gln 
65                  70                  75                  80  


Gln Glu Asn Lys Glu Leu Arg Thr Ser Leu Glu Glu His Gln Ser Ala 
                85                  90                  95      


Leu Glu Leu Ile Met Ser Lys Tyr Arg Glu Gln Met Phe Arg Leu Leu 
            100                 105                 110         


Met Ala Ser Lys Lys Asp Asp Pro Gly Ile Ile Met Lys Leu Lys Glu 
        115                 120                 125             


Gln His Ser Lys Glu Leu Gln Ala His Val Asp Gln Ile Thr Glu Met 
    130                 135                 140                 


Ala Ala Val Met Arg Lys Ala Ile Glu Ile Asp Glu Gln Gln Gly Cys 
145                 150                 155                 160 


Lys Glu Gln Glu Arg Ile Phe Gln Leu Glu Gln Glu Asn Lys Gly Leu 
                165                 170                 175     


Arg Glu Ile Leu Gln Ile Thr Arg Glu Ser Phe Leu Asn Leu Arg Lys 
            180                 185                 190         


Asp Asp Ala Ser Glu Ser Thr Ser Leu Ser Ala Leu Val Thr Asn Ser 
        195                 200                 205             


Asp Leu Ser Leu Arg Lys Ser 
    210                 215 


<210> 5500
<211> 891
<212> PRT
<213> Homo sapiens

<400> 5500
Met Ala Val Ala Arg Val Asp Ala Ala Leu Pro Pro Gly Glu Gly Ser 
1               5                   10                  15      


Val Val Asn Trp Ser Gly Gln Gly Leu Gln Lys Leu Gly Pro Asn Leu 
            20                  25                  30          


Pro Cys Glu Ala Asp Ile His Thr Leu Ile Leu Asp Lys Asn Gln Ile 
        35                  40                  45              


Ile Lys Leu Glu Asn Leu Glu Lys Cys Lys Arg Leu Ile Gln Leu Ser 
    50                  55                  60                  


Val Ala Asn Asn Arg Leu Val Arg Met Met Gly Val Ala Lys Leu Thr 
65                  70                  75                  80  


Leu Leu Arg Val Leu Asn Leu Pro His Asn Ser Ile Gly Cys Val Glu 
                85                  90                  95      


Gly Leu Lys Glu Leu Val His Leu Glu Trp Leu Asn Leu Ala Gly Asn 
            100                 105                 110         


Asn Leu Lys Ala Met Glu Gln Ile Asn Ser Cys Thr Ala Leu Gln His 
        115                 120                 125             


Leu Asp Leu Ser Asp Asn Asn Ile Ser Gln Ile Gly Asp Leu Ser Lys 
    130                 135                 140                 


Leu Val Ser Leu Lys Thr Leu Leu Leu His Gly Asn Ile Ile Thr Ser 
145                 150                 155                 160 


Leu Arg Met Ala Pro Ala Tyr Leu Pro Arg Ser Leu Ala Ile Leu Ser 
                165                 170                 175     


Leu Ala Glu Asn Glu Ile Arg Asp Leu Asn Glu Ile Ser Phe Leu Ala 
            180                 185                 190         


Ser Leu Thr Glu Leu Glu Gln Leu Ser Ile Met Asn Asn Pro Cys Val 
        195                 200                 205             


Met Ala Thr Pro Ser Ile Pro Gly Phe Asp Tyr Arg Pro Tyr Ile Val 
    210                 215                 220                 


Ser Trp Cys Leu Asn Leu Arg Val Leu Asp Gly Tyr Val Ile Ser Gln 
225                 230                 235                 240 


Lys Glu Ser Leu Lys Ala Glu Trp Leu Tyr Ser Gln Gly Lys Gly Arg 
                245                 250                 255     


Ala Tyr Arg Pro Gly Gln His Ile Gln Leu Val Gln Tyr Leu Ala Thr 
            260                 265                 270         


Val Cys Pro Leu Thr Ser Thr Leu Gly Leu Gln Thr Ala Glu Asp Ala 
        275                 280                 285             


Lys Leu Glu Lys Ile Leu Ser Lys Gln Arg Phe His Gln Arg Gln Leu 
    290                 295                 300                 


Met Asn Gln Ser Gln Asn Glu Glu Leu Ser Pro Leu Val Pro Val Glu 
305                 310                 315                 320 


Thr Arg Ala Ser Leu Ile Pro Glu His Ser Ser Pro Val Gln Asp Cys 
                325                 330                 335     


Gln Ile Ser Gln Glu Ser Glu Pro Val Ile Gln Val Asn Ser Trp Val 
            340                 345                 350         


Gly Ile Asn Ser Asn Asp Asp Gln Leu Phe Ala Val Lys Asn Asn Phe 
        355                 360                 365             


Pro Ala Ser Val His Thr Thr Arg Tyr Ser Arg Asn Asp Leu His Leu 
    370                 375                 380                 


Glu Asp Ile Gln Thr Asp Glu Asp Lys Leu Asn Cys Ser Leu Leu Ser 
385                 390                 395                 400 


Ser Glu Ser Thr Phe Met Pro Val Ala Ser Gly Leu Ser Pro Leu Ser 
                405                 410                 415     


Pro Thr Val Glu Leu Arg Leu Gln Gly Ile Asn Leu Gly Leu Glu Asp 
            420                 425                 430         


Asp Gly Val Ala Asp Glu Ser Val Lys Gly Leu Glu Ser Gln Val Leu 
        435                 440                 445             


Asp Lys Glu Glu Glu Gln Pro Leu Trp Ala Ala Asn Glu Asn Ser Val 
    450                 455                 460                 


Gln Met Met Arg Ser Glu Ile Asn Thr Glu Val Asn Glu Lys Ala Gly 
465                 470                 475                 480 


Leu Leu Pro Cys Pro Glu Pro Thr Ile Ile Ser Ala Ile Leu Lys Asp 
                485                 490                 495     


Asp Asn His Ser Leu Thr Phe Phe Pro Glu Ser Thr Glu Gln Lys Gln 
            500                 505                 510         


Ser Asp Ile Lys Lys Pro Glu Asn Thr Gln Pro Glu Asn Lys Glu Thr 
        515                 520                 525             


Ile Ser Gln Ala Thr Ser Glu Lys Leu Pro Met Ile Leu Thr Gln Arg 
    530                 535                 540                 


Ser Val Ala Leu Gly Gln Asp Lys Val Ala Leu Gln Lys Leu Asn Asp 
545                 550                 555                 560 


Ala Ala Thr Lys Leu Gln Ala Cys Trp Arg Gly Phe Tyr Ala Arg Asn 
                565                 570                 575     


Tyr Asn Pro Gln Ala Lys Asp Val Arg Tyr Glu Ile Arg Leu Arg Arg 
            580                 585                 590         


Met Gln Glu His Ile Val Cys Leu Thr Asp Glu Ile Arg Arg Leu Arg 
        595                 600                 605             


Lys Glu Arg Asp Glu Glu Arg Ile Lys Lys Phe Val Gln Glu Glu Ala 
    610                 615                 620                 


Phe Arg Phe Leu Trp Asn Gln Lys Trp Gly Leu Ala Ile Leu Pro Arg 
625                 630                 635                 640 


Pro Val Ser Asn Phe Trp Ala Gln Ala Val Phe Pro Pro Gln Pro Pro 
                645                 650                 655     


Lys Val Arg Ser Leu Gln Val Trp Gln Gln Thr Val Asp Gln Arg Leu 
            660                 665                 670         


Ser Ser Trp His Thr Asp Val Pro Pro Ile Ser Ser Thr Leu Val Pro 
        675                 680                 685             


Ser Lys His Pro Leu Phe Thr Gln Ser Gln Glu Ser Ser Cys Asp Gln 
    690                 695                 700                 


Asn Ala Asp Trp Phe Ile Ala Ser Asp Val Ala Pro Gln Glu Lys Ser 
705                 710                 715                 720 


Leu Pro Glu Phe Pro Asp Ser Gly Phe His Ser Ser Leu Thr Glu Gln 
                725                 730                 735     


Val His Ser Leu Gln His Ser Leu Asp Phe Glu Lys Ser Ser Thr Glu 
            740                 745                 750         


Gly Ser Glu Ser Ser Ile Met Gly Asn Ser Ile Asp Thr Val Arg Tyr 
        755                 760                 765             


Gly Lys Glu Ser Asp Leu Gly Asp Val Ser Glu Glu His Gly Glu Trp 
    770                 775                 780                 


Asn Lys Glu Ser Ser Asn Asn Glu Gln Asp Asn Ser Leu Leu Glu Gln 
785                 790                 795                 800 


Tyr Leu Thr Ser Val Gln Gln Leu Glu Asp Ala Asp Glu Arg Thr Asn 
                805                 810                 815     


Phe Asp Thr Glu Thr Arg Asp Ser Lys Leu His Ile Ala Cys Phe Pro 
            820                 825                 830         


Val Gln Leu Asp Thr Leu Ser Asp Gly Ala Ser Val Asp Glu Ser His 
        835                 840                 845             


Gly Ile Ser Pro Pro Leu Gln Gly Glu Ile Ser Gln Thr Gln Glu Asn 
    850                 855                 860                 


Ser Lys Leu Asn Ala Glu Val Gln Gly Gln Gln Pro Glu Cys Asp Ser 
865                 870                 875                 880 


Thr Phe Gln Leu Leu His Val Gly Val Thr Val 
                885                 890     


<210> 5501
<211> 275
<212> PRT
<213> Homo sapiens

<400> 5501
Met Ala Glu Pro Ala Ser Val Ala Ala Glu Ser Leu Ala Gly Ser Arg 
1               5                   10                  15      


Ala Arg Ala Ala Arg Thr Val Leu Gly Gln Val Val Leu Pro Gly Glu 
            20                  25                  30          


Glu Leu Leu Leu Pro Glu Gln Glu Asp Ala Glu Gly Pro Gly Gly Ala 
        35                  40                  45              


Val Glu Arg Pro Leu Ser Leu Asn Ala Arg Ala Cys Ser Arg Val Arg 
    50                  55                  60                  


Val Val Cys Gly Pro Gly Leu Arg Arg Cys Gly Asp Arg Leu Leu Val 
65                  70                  75                  80  


Thr Lys Cys Gly Arg Leu Arg His Lys Glu Pro Gly Ser Gly Ser Gly 
                85                  90                  95      


Gly Gly Val Tyr Trp Val Asp Ser Gln Gln Lys Arg Tyr Val Pro Val 
            100                 105                 110         


Lys Gly Asp His Val Ile Gly Ile Val Thr Ala Lys Ser Gly Asp Ile 
        115                 120                 125             


Phe Lys Val Asp Val Gly Gly Ser Glu Pro Ala Ser Leu Ser Tyr Leu 
    130                 135                 140                 


Ser Phe Glu Gly Ala Thr Lys Arg Asn Arg Pro Asn Val Gln Val Gly 
145                 150                 155                 160 


Asp Leu Ile Tyr Gly Gln Phe Val Val Ala Asn Lys Asp Met Glu Pro 
                165                 170                 175     


Glu Met Val Cys Ile Asp Ser Cys Gly Arg Ala Asn Gly Met Gly Val 
            180                 185                 190         


Ile Gly Gln Asp Gly Leu Leu Phe Lys Val Thr Leu Gly Leu Ile Arg 
        195                 200                 205             


Lys Leu Leu Ala Pro Asp Cys Glu Ile Ile Gln Glu Val Gly Lys Leu 
    210                 215                 220                 


Tyr Pro Leu Glu Ile Val Phe Gly Met Asn Gly Arg Ile Trp Val Lys 
225                 230                 235                 240 


Ala Lys Thr Ile Gln Gln Thr Leu Ile Leu Ala Asn Ile Leu Glu Ala 
                245                 250                 255     


Cys Glu His Met Thr Ser Asp Gln Arg Lys Gln Ile Phe Ser Arg Leu 
            260                 265                 270         


Ala Glu Ser 
        275 


<210> 5502
<211> 539
<212> PRT
<213> Homo sapiens

<400> 5502
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 5503
<211> 410
<212> PRT
<213> Homo sapiens

<400> 5503
Met Phe Asn Asn Glu Leu Met Ala Asp Val His Phe Val Val Gly Pro 
1               5                   10                  15      


Pro Gly Ala Thr Arg Thr Val Pro Ala His Lys Tyr Val Leu Ala Val 
            20                  25                  30          


Gly Ser Ser Val Phe Tyr Ala Met Phe Tyr Gly Asp Leu Ala Glu Val 
        35                  40                  45              


Lys Ser Glu Ile His Ile Pro Asp Val Glu Pro Ala Ala Phe Leu Ile 
    50                  55                  60                  


Leu Leu Lys Tyr Met Tyr Ser Asp Glu Ile Asp Leu Glu Ala Asp Thr 
65                  70                  75                  80  


Val Leu Ala Thr Leu Tyr Ala Ala Lys Lys Tyr Ile Val Pro Ala Leu 
                85                  90                  95      


Ala Lys Ala Cys Val Asn Phe Leu Glu Thr Ser Leu Glu Ala Lys Asn 
            100                 105                 110         


Ala Cys Val Leu Leu Ser Gln Ser Arg Leu Phe Glu Glu Pro Glu Leu 
        115                 120                 125             


Thr Gln Arg Cys Trp Glu Val Ile Asp Ala Gln Ala Glu Met Ala Leu 
    130                 135                 140                 


Arg Ser Glu Gly Phe Cys Glu Ile Asp Arg Gln Thr Leu Glu Ile Ile 
145                 150                 155                 160 


Val Thr Arg Glu Ala Leu Asn Thr Lys Glu Ala Val Val Phe Glu Ala 
                165                 170                 175     


Val Leu Asn Trp Ala Glu Ala Glu Cys Lys Arg Gln Gly Leu Pro Ile 
            180                 185                 190         


Thr Pro Arg Asn Lys Arg His Val Leu Gly Arg Ala Leu Tyr Leu Val 
        195                 200                 205             


Arg Ile Pro Thr Met Thr Leu Glu Glu Phe Ala Asn Gly Ala Ala Gln 
    210                 215                 220                 


Ser Asp Ile Leu Thr Leu Glu Glu Thr His Ser Ile Phe Leu Trp Tyr 
225                 230                 235                 240 


Thr Ala Thr Asn Lys Pro Arg Leu Asp Phe Pro Leu Thr Lys Arg Lys 
                245                 250                 255     


Gly Leu Ala Pro Gln Arg Cys His Arg Phe Gln Ser Ser Ala Tyr Arg 
            260                 265                 270         


Ser Asn Gln Trp Arg Tyr Arg Gly Arg Cys Asp Ser Ile Gln Phe Ala 
        275                 280                 285             


Val Asp Arg Arg Val Phe Ile Ala Gly Leu Gly Leu Tyr Gly Ser Ser 
    290                 295                 300                 


Ser Gly Lys Ala Glu Tyr Ser Val Lys Ile Glu Leu Lys Arg Leu Gly 
305                 310                 315                 320 


Val Val Leu Ala Gln Asn Leu Thr Lys Phe Met Ser Asp Gly Ser Ser 
                325                 330                 335     


Asn Thr Phe Pro Val Trp Phe Glu His Pro Val Gln Val Glu Gln Asp 
            340                 345                 350         


Thr Phe Tyr Thr Ala Ser Ala Val Leu Asp Gly Ser Glu Leu Ser Tyr 
        355                 360                 365             


Phe Gly Gln Glu Gly Met Thr Glu Val Gln Cys Gly Lys Val Ala Phe 
    370                 375                 380                 


Gln Phe Gln Cys Ser Ser Asp Ser Thr Asn Gly Thr Gly Val Gln Gly 
385                 390                 395                 400 


Gly Gln Ile Pro Glu Leu Ile Phe Tyr Ala 
                405                 410 


<210> 5504
<211> 321
<212> PRT
<213> Homo sapiens

<400> 5504
Met Arg Ala Leu Ala Ala Leu Ser Ala Pro Pro Asn Glu Arg Leu Leu 
1               5                   10                  15      


Pro Arg Asp Pro Ala Ala Thr Arg Asp Pro Asp Ala Ala Arg Pro Ala 
            20                  25                  30          


Arg Arg Ser Ala Val Glu Arg Leu Ala Ala Asp Arg Ala Lys Tyr Val 
        35                  40                  45              


Arg Gly Arg Pro Gly Thr Gly Arg Gly Val Ala Ser Glu Gly Ser Gly 
    50                  55                  60                  


Pro Gly Ala Ile Lys Cys Pro Gly Asn Asp Pro Gly Pro Pro Ala Arg 
65                  70                  75                  80  


Ala Pro Ala Pro Val Ala Arg Arg Ala Ile Ala Arg Lys Pro Leu Arg 
                85                  90                  95      


Pro Asp Ser Leu Ile Ile Tyr Arg Gln Lys Cys Glu Phe Val Arg Gly 
            100                 105                 110         


Ser Gly Ala Asp Gly Pro Arg Ala Ser Leu Val Lys Lys Leu Phe Gln 
        115                 120                 125             


Gly Pro Gly Lys Asp Lys Ala Pro Val Pro Arg Thr Gly Asp Glu Gly 
    130                 135                 140                 


Lys Ala Gly Asn Pro Glu Thr Val Pro Thr Thr Pro Gly Pro Ala Ala 
145                 150                 155                 160 


Asp Pro Ala Ile Pro Glu Thr Pro Ala Pro Ala Ala Arg Ser Ala Ala 
                165                 170                 175     


Pro Ser Ser Val Pro Ala Ala Pro Pro Gly Pro Glu Pro Arg Val Val 
            180                 185                 190         


Arg Arg Arg Gly Leu Gln Arg Ser Gln Ser Asp Leu Ser Ser Arg Tyr 
        195                 200                 205             


Ser Ala Ala Leu Ala Glu Ser Asp Thr Phe Phe Gln Tyr Cys Gly Leu 
    210                 215                 220                 


Asp Pro Glu Val Val Glu Ala Leu Gly Arg Glu Asn Phe Thr Ala Gly 
225                 230                 235                 240 


Ser Asp Cys Val Thr Leu Lys Val Arg Ser Val Ser Val Ala Thr Ser 
                245                 250                 255     


Gly Ser Gly Phe Ser Arg His Ser Gly Gly Asp Asp Glu Gly Leu Gln 
            260                 265                 270         


Glu Glu Glu Leu Ile Glu Gln Val Pro Ser Thr Thr Ser Val Ile Glu 
        275                 280                 285             


Arg Asn Ala Arg Ile Ile Lys Trp Leu Tyr Thr Cys Lys Lys Ala Lys 
    290                 295                 300                 


Glu Thr Pro Ser Gln Glu Gln Ser Arg Thr Arg Gly Ser Lys Pro Ser 
305                 310                 315                 320 


Arg 
    


<210> 5505
<211> 314
<212> PRT
<213> Homo sapiens

<400> 5505
Met Ser Glu Asn Ala Ala Pro Gly Leu Ile Ser Glu Leu Lys Leu Ala 
1               5                   10                  15      


Val Pro Trp Gly His Ile Ala Ala Lys Ala Trp Gly Ser Leu Gln Gly 
            20                  25                  30          


Pro Pro Val Leu Cys Leu His Gly Trp Leu Asp Asn Ala Ser Ser Phe 
        35                  40                  45              


Asp Arg Leu Ile Pro Leu Leu Pro Gln Asp Phe Tyr Tyr Val Ala Met 
    50                  55                  60                  


Asp Phe Gly Gly His Gly Leu Ser Ser His Tyr Ser Pro Gly Val Pro 
65                  70                  75                  80  


Tyr Tyr Leu Gln Thr Phe Val Ser Glu Ile Arg Arg Val Val Ala Ala 
                85                  90                  95      


Leu Lys Trp Asn Arg Phe Ser Ile Leu Gly His Ser Phe Gly Gly Val 
            100                 105                 110         


Val Gly Gly Met Phe Phe Cys Thr Phe Pro Glu Met Val Asp Lys Leu 
        115                 120                 125             


Ile Leu Leu Asp Thr Pro Leu Phe Leu Leu Glu Ser Asp Glu Met Glu 
    130                 135                 140                 


Asn Leu Leu Thr Tyr Lys Arg Arg Ala Ile Glu His Val Leu Gln Val 
145                 150                 155                 160 


Glu Ala Ser Gln Glu Pro Ser His Val Phe Ser Leu Lys Gln Leu Leu 
                165                 170                 175     


Gln Arg Leu Leu Lys Ser Asn Ser His Leu Ser Glu Glu Cys Gly Glu 
            180                 185                 190         


Leu Leu Leu Gln Arg Gly Thr Thr Lys Val Ala Thr Gly Leu Val Leu 
        195                 200                 205             


Asn Arg Asp Gln Arg Leu Ala Trp Ala Glu Asn Ser Ile Asp Phe Ile 
    210                 215                 220                 


Ser Arg Glu Leu Cys Ala His Ser Ile Arg Lys Leu Gln Ala His Val 
225                 230                 235                 240 


Leu Leu Ile Lys Ala Val His Gly Tyr Phe Asp Ser Arg Gln Asn Tyr 
                245                 250                 255     


Ser Glu Lys Glu Ser Leu Ser Phe Met Ile Asp Thr Met Lys Ser Thr 
            260                 265                 270         


Leu Lys Glu Gln Phe Gln Phe Val Glu Val Pro Gly Asn His Cys Val 
        275                 280                 285             


His Met Ser Glu Pro Gln His Val Ala Ser Ile Ile Ser Ser Phe Leu 
    290                 295                 300                 


Gln Cys Thr His Met Leu Pro Ala Gln Leu 
305                 310                 


<210> 5506
<211> 1314
<212> PRT
<213> Homo sapiens

<400> 5506
Met Ala Ser Lys Gly Ala Gly Met Ser Phe Ser Arg Lys Ser Tyr Arg 
1               5                   10                  15      


Leu Thr Ser Asp Ala Glu Lys Ser Arg Val Thr Gly Ile Val Gln Glu 
            20                  25                  30          


Lys Leu Leu Asn Asp Tyr Leu Asn Arg Ile Phe Ser Ser Ser Glu His 
        35                  40                  45              


Ala Pro Pro Ala Ala Thr Ser Arg Lys Pro Leu Asn Phe Gln Asn Leu 
    50                  55                  60                  


Pro Glu His Leu Asp Gln Leu Leu Gln Val Asp Asn Glu Glu Glu Glu 
65                  70                  75                  80  


Ser Gln Gly Gln Val Glu Gly Arg Leu Gly Pro Ser Thr Val Val Leu 
                85                  90                  95      


Asp His Thr Gly Gly Phe Glu Gly Leu Leu Leu Val Asp Asp Asp Leu 
            100                 105                 110         


Leu Gly Val Ile Gly His Ser Asn Phe Gly Thr Ile Arg Ser Thr Thr 
        115                 120                 125             


Cys Val Tyr Lys Gly Lys Trp Leu Tyr Glu Val Leu Ile Ser Ser Gln 
    130                 135                 140                 


Gly Leu Met Gln Ile Gly Trp Cys Thr Ile Ser Cys Arg Phe Asn Gln 
145                 150                 155                 160 


Glu Glu Gly Val Gly Asp Thr His Asn Ser Tyr Ala Tyr Asp Gly Asn 
                165                 170                 175     


Arg Val Arg Lys Trp Asn Val Thr Thr Thr Asn Tyr Gly Lys Ala Trp 
            180                 185                 190         


Ala Ala Gly Asp Ile Val Ser Cys Leu Ile Asp Leu Asp Asp Gly Thr 
        195                 200                 205             


Leu Ser Phe Cys Leu Asn Gly Val Ser Leu Gly Thr Ala Phe Glu Asn 
    210                 215                 220                 


Leu Ser Arg Gly Leu Gly Met Ala Tyr Phe Pro Ala Ile Ser Leu Ser 
225                 230                 235                 240 


Phe Lys Glu Ser Val Ala Phe Asn Phe Gly Ser Arg Pro Leu Arg Tyr 
                245                 250                 255     


Pro Val Ala Gly Tyr Arg Pro Leu Gln Asp Pro Pro Ser Ala Asp Leu 
            260                 265                 270         


Val Arg Ala Gln Arg Leu Leu Gly Cys Phe Arg Ala Val Leu Ser Val 
        275                 280                 285             


Glu Leu Asp Pro Val Glu Gly Arg Leu Leu Asp Lys Glu Ser Ser Lys 
    290                 295                 300                 


Trp Arg Leu Arg Gly Gln Pro Thr Val Leu Leu Thr Leu Ala His Ile 
305                 310                 315                 320 


Phe His His Phe Ala Pro Leu Leu Arg Lys Val Tyr Leu Val Glu Ala 
                325                 330                 335     


Val Leu Met Ser Phe Leu Leu Gly Ile Val Glu Lys Gly Thr Pro Thr 
            340                 345                 350         


Gln Ala Gln Ser Val Val His Gln Val Leu Asp Leu Leu Trp Leu Phe 
        355                 360                 365             


Met Glu Asp Tyr Glu Val Gln Asp Cys Leu Lys Gln Leu Met Met Ser 
    370                 375                 380                 


Leu Leu Arg Leu Tyr Arg Phe Ser Pro Ile Val Pro Asp Leu Gly Leu 
385                 390                 395                 400 


Gln Ile His Tyr Leu Arg Leu Thr Ile Ala Ile Leu Arg His Glu Lys 
                405                 410                 415     


Ser Arg Lys Phe Leu Leu Ser Asn Val Leu Phe Asp Val Leu Arg Ser 
            420                 425                 430         


Val Val Phe Phe Tyr Ile Lys Ser Pro Leu Arg Val Glu Glu Ala Gly 
        435                 440                 445             


Leu Gln Glu Leu Ile Pro Thr Thr Trp Trp Pro His Cys Ser Ser Arg 
    450                 455                 460                 


Glu Gly Lys Glu Ser Thr Glu Met Lys Glu Glu Thr Ala Glu Glu Arg 
465                 470                 475                 480 


Leu Arg Arg Arg Ala Tyr Glu Arg Gly Cys Gln Arg Leu Arg Lys Arg 
                485                 490                 495     


Ile Glu Val Val Glu Glu Leu Gln Val Gln Ile Leu Lys Leu Leu Leu 
            500                 505                 510         


Asp Asn Lys Asp Asp Asn Gly Gly Glu Ala Ser Arg Tyr Ile Phe Leu 
        515                 520                 525             


Thr Lys Phe Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly Asn 
    530                 535                 540                 


Met Pro Met Leu Cys Pro Pro Glu Tyr Met Val Cys Phe Leu His Arg 
545                 550                 555                 560 


Leu Ile Ser Ala Leu Arg Tyr Tyr Trp Asp Glu Tyr Lys Ala Ser Asn 
                565                 570                 575     


Pro His Ala Ser Phe Ser Glu Glu Ala Tyr Ile Pro Pro Gln Val Phe 
            580                 585                 590         


Tyr Asn Gly Lys Val Asp Tyr Phe Asp Leu Gln Arg Leu Gly Gly Leu 
        595                 600                 605             


Leu Ser His Leu Arg Lys Thr Leu Lys Asp Asp Leu Ala Ser Lys Ala 
    610                 615                 620                 


Asn Ile Val Ile Asp Pro Leu Glu Leu Gln Ser Thr Ala Met Asp Asp 
625                 630                 635                 640 


Leu Asp Glu Asp Glu Glu Pro Ala Pro Ala Met Ala Gln Arg Pro Met 
                645                 650                 655     


Gln Ala Leu Ala Val Gly Gly Pro Leu Pro Leu Pro Arg Pro Gly Trp 
            660                 665                 670         


Leu Ser Ser Pro Thr Leu Gly Arg Ala Asn Arg Phe Leu Ser Thr Ala 
        675                 680                 685             


Ala Val Ser Leu Met Thr Pro Arg Arg Pro Leu Ser Thr Ser Glu Lys 
    690                 695                 700                 


Val Lys Val Arg Thr Leu Ser Val Glu Gln Arg Thr Arg Glu Asp Ile 
705                 710                 715                 720 


Glu Gly Ser His Trp Asn Glu Gly Leu Leu Leu Gly Arg Pro Pro Glu 
                725                 730                 735     


Glu Pro Glu Gln Pro Leu Thr Glu Asn Ser Leu Leu Glu Val Leu Asp 
            740                 745                 750         


Gly Ala Val Met Met Tyr Asn Leu Ser Val His Gln Gln Leu Gly Lys 
        755                 760                 765             


Met Val Gly Val Ser Asp Asp Val Asn Glu Tyr Ala Met Ala Leu Arg 
    770                 775                 780                 


Asp Thr Glu Asp Lys Leu Arg Arg Cys Pro Lys Arg Arg Lys Asp Ile 
785                 790                 795                 800 


Leu Ala Glu Leu Thr Lys Ser Gln Lys Val Phe Ser Glu Lys Leu Asp 
                805                 810                 815     


His Leu Ser Arg Arg Leu Ala Trp Val His Ala Thr Val Tyr Ser Gln 
            820                 825                 830         


Glu Lys Met Leu Asp Ile Tyr Trp Leu Leu Arg Val Cys Leu Arg Thr 
        835                 840                 845             


Ile Glu His Gly Asp Arg Thr Gly Ser Leu Phe Ala Phe Met Pro Glu 
    850                 855                 860                 


Phe Tyr Leu Ser Val Ala Ile Asn Ser Tyr Ser Ala Leu Lys Asn Tyr 
865                 870                 875                 880 


Phe Gly Pro Val His Ser Met Glu Glu Leu Pro Gly Tyr Glu Glu Thr 
                885                 890                 895     


Leu Thr Arg Leu Ala Ala Ile Leu Ala Lys His Phe Ala Asp Ala Arg 
            900                 905                 910         


Ile Val Gly Thr Asp Ile Arg Asp Ser Leu Met Gln Ala Leu Ala Ser 
        915                 920                 925             


Tyr Val Cys Tyr Pro His Ser Leu Arg Ala Val Glu Arg Ile Pro Glu 
    930                 935                 940                 


Glu Gln Arg Ile Ala Met Val Arg Asn Leu Leu Ala Pro Tyr Glu Gln 
945                 950                 955                 960 


Arg Pro Trp Ala Gln Thr Asn Trp Ile Leu Val Arg Leu Trp Arg Gly 
                965                 970                 975     


Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu Leu Lys Thr 
            980                 985                 990         


Lys Leu Glu Asp Ala Asn Leu Pro  Ser Leu Gln Lys Pro  Cys Pro Ser 
        995                 1000                 1005             


Thr Leu  Leu Gln Gln His Met  Ala Asp Leu Leu Gln  Gln Gly Pro 
    1010                 1015                 1020             


Asp Val  Ala Pro Ser Phe Leu  Asn Ser Val Leu Asn  Gln Leu Asn 
    1025                 1030                 1035             


Trp Ala  Phe Ser Glu Phe Ile  Gly Met Ile Gln Glu  Ile Gln Gln 
    1040                 1045                 1050             


Ala Ala  Glu Arg Leu Glu Arg  Asn Phe Val Asp Ser  Arg Gln Leu 
    1055                 1060                 1065             


Lys Val  Cys Ala Thr Cys Phe  Asp Leu Ser Val Ser  Leu Leu Arg 
    1070                 1075                 1080             


Val Leu  Glu Met Thr Ile Thr  Leu Val Pro Glu Ile  Phe Leu Asp 
    1085                 1090                 1095             


Trp Thr  Arg Pro Thr Ser Glu  Met Leu Leu Arg Arg  Leu Ala Gln 
    1100                 1105                 1110             


Leu Leu  Asn Gln Val Leu Asn  Arg Val Thr Ala Glu  Arg Asn Leu 
    1115                 1120                 1125             


Phe Asp  Arg Val Val Thr Leu  Arg Leu Pro Gly Leu  Glu Ser Val 
    1130                 1135                 1140             


Asp His  Tyr Pro Ile Leu Val  Ala Val Thr Gly Ile  Leu Val Gln 
    1145                 1150                 1155             


Leu Leu  Val Arg Gly Pro Ala  Ser Glu Arg Glu Gln  Ala Thr Ser 
    1160                 1165                 1170             


Val Leu  Leu Ala Asp Pro Cys  Phe Gln Leu Arg Ser  Ile Cys Tyr 
    1175                 1180                 1185             


Leu Leu  Gly Gln Pro Glu Pro  Pro Ala Pro Gly Thr  Ala Leu Pro 
    1190                 1195                 1200             


Ala Pro  Asp Arg Lys Arg Phe  Ser Leu Gln Ser Tyr  Ala Asp Tyr 
    1205                 1210                 1215             


Ile Ser  Ala Asp Glu Leu Ala  Gln Val Glu Gln Met  Leu Ala His 
    1220                 1225                 1230             


Leu Thr  Ser Ala Ser Ala Gln  Ala Ala Ala Ala Ser  Leu Pro Thr 
    1235                 1240                 1245             


Ser Glu  Glu Asp Leu Cys Pro  Ile Cys Tyr Ala His  Pro Ile Ser 
    1250                 1255                 1260             


Ala Val  Phe Gln Pro Cys Gly  His Lys Ser Cys Lys  Ala Cys Ile 
    1265                 1270                 1275             


Asn Gln  His Leu Met Asn Asn  Lys Asp Cys Phe Phe  Cys Lys Thr 
    1280                 1285                 1290             


Thr Ile  Val Ser Val Glu Asp  Trp Glu Lys Gly Ala  Asn Thr Ser 
    1295                 1300                 1305             


Thr Thr  Ser Ser Ala Ala 
    1310                 


<210> 5507
<211> 881
<212> PRT
<213> Homo sapiens

<400> 5507
Met Ala Gly Ala Ala Pro Arg Val Arg Tyr Leu Ala Gly Phe Cys Cys 
1               5                   10                  15      


Pro Leu Gly Gly Leu Ala Ala Gly Lys Pro Arg Val Leu Cys His Glu 
            20                  25                  30          


Ala Glu Val Phe Leu Ser Thr Gly Ser Glu Leu Val Tyr Val Tyr Asp 
        35                  40                  45              


Gln Glu Gly Gly Leu Leu Thr Ala Ala Phe Arg Phe Pro Asp Gln Val 
    50                  55                  60                  


Trp His Leu Glu Leu Leu Ala Pro Arg Arg Leu Leu Tyr Ala Leu Cys 
65                  70                  75                  80  


Ala Arg Arg Gly Leu Tyr Cys Leu Ser Leu Asp His Pro Gly Arg Ser 
                85                  90                  95      


Arg Ser Thr Ser Gln Asp Asp Arg Asp Ser Glu Asp Gly Asp Gln Pro 
            100                 105                 110         


Ser Pro Val Ile Pro Val Asp Pro Asp Ala Cys Ile Leu Pro Asp Ala 
        115                 120                 125             


Ala Leu Cys Ala Phe Thr Leu Leu Asp Ser Val Leu Val Thr Leu Val 
    130                 135                 140                 


Gln Gly Pro Ala Arg Trp Lys Met Gln Leu Phe Glu Gln Pro Cys Pro 
145                 150                 155                 160 


Gly Glu Asp Pro Arg Pro Gly Gly Gln Ile Gly Glu Val Glu Leu Ser 
                165                 170                 175     


Ser Tyr Thr Pro Pro Ala Gly Val Pro Gly Lys Pro Ala Ala Pro His 
            180                 185                 190         


Phe Leu Pro Val Leu Cys Ser Val Ser Pro Ser Gly Ser Arg Val Pro 
        195                 200                 205             


His Asp Leu Leu Gly Gly Ser Gly Gly Phe Thr Leu Glu Asp Ala Leu 
    210                 215                 220                 


Phe Gly Leu Leu Phe Gly Ala Asp Ala Thr Leu Leu Gln Ser Pro Val 
225                 230                 235                 240 


Val Leu Cys Gly Leu Pro Asp Gly Gln Leu Cys Cys Val Ile Leu Lys 
                245                 250                 255     


Ala Leu Val Thr Ser Arg Ser Ala Pro Gly Asp Pro Asn Ala Leu Val 
            260                 265                 270         


Lys Ile Leu His His Leu Glu Glu Pro Val Ile Phe Ile Gly Ala Leu 
        275                 280                 285             


Lys Thr Glu Pro Gln Ala Ala Glu Ala Ala Glu Asn Phe Leu Pro Asp 
    290                 295                 300                 


Glu Asp Val His Cys Asp Cys Leu Val Ala Phe Gly His His Gly Arg 
305                 310                 315                 320 


Met Leu Ala Ile Lys Ala Ser Trp Asp Glu Ser Gly Lys Leu Val Pro 
                325                 330                 335     


Glu Leu Arg Glu Tyr Cys Leu Pro Gly Pro Val Leu Cys Ala Ala Cys 
            340                 345                 350         


Gly Gly Gly Gly Arg Val Tyr His Ser Thr Pro Ser Asp Leu Cys Val 
        355                 360                 365             


Val Asp Leu Ser Arg Gly Ser Thr Pro Leu Gly Pro Glu Gln Pro Glu 
    370                 375                 380                 


Glu Gly Pro Gly Gly Leu Pro Pro Met Leu Cys Pro Ala Ser Leu Asn 
385                 390                 395                 400 


Ile Cys Ser Val Val Ser Leu Ser Ala Ser Pro Arg Thr His Glu Gly 
                405                 410                 415     


Gly Thr Lys Leu Leu Ala Leu Ser Ala Lys Gly Arg Leu Met Thr Cys 
            420                 425                 430         


Ser Leu Asp Leu Asp Ser Glu Met Pro Gly Pro Ala Arg Met Thr Thr 
        435                 440                 445             


Glu Ser Ala Gly Gln Lys Ile Lys Glu Leu Leu Ser Gly Ile Gly Asn 
    450                 455                 460                 


Ile Ser Glu Arg Val Ser Phe Leu Lys Lys Ala Val Asp Gln Arg Asn 
465                 470                 475                 480 


Lys Ala Leu Thr Ser Leu Asn Glu Ala Met Asn Val Ser Cys Ala Leu 
                485                 490                 495     


Leu Ser Ser Gly Thr Gly Pro Arg Pro Ile Ser Cys Thr Thr Ser Thr 
            500                 505                 510         


Thr Trp Ser Arg Leu Gln Thr Gln Asp Val Leu Met Ala Thr Cys Val 
        515                 520                 525             


Leu Glu Asn Ser Ser Ser Phe Ser Leu Asp Gln Gly Trp Thr Leu Cys 
    530                 535                 540                 


Ile Gln Val Leu Thr Ser Ser Cys Ala Leu Asp Leu Asp Ser Ala Cys 
545                 550                 555                 560 


Ser Ala Ile Thr Tyr Thr Ile Pro Val Asp Gln Leu Gly Pro Gly Ala 
                565                 570                 575     


Arg Arg Glu Val Thr Leu Pro Leu Gly Pro Gly Glu Asn Gly Gly Leu 
            580                 585                 590         


Asp Leu Pro Val Thr Val Ser Cys Thr Leu Phe Tyr Ser Leu Arg Glu 
        595                 600                 605             


Val Val Gly Gly Ala Leu Ala Pro Ser Asp Ser Glu Asp Pro Phe Leu 
    610                 615                 620                 


Asp Glu Cys Pro Ser Asp Val Leu Pro Glu Gln Glu Gly Val Cys Leu 
625                 630                 635                 640 


Pro Leu Ser Arg His Thr Val Asp Met Leu Gln Cys Leu Arg Phe Pro 
                645                 650                 655     


Gly Leu Ala Pro Pro His Thr Arg Ala Pro Ser Pro Leu Gly Pro Thr 
            660                 665                 670         


Arg Asp Pro Val Ala Thr Phe Leu Glu Thr Cys Arg Glu Pro Gly Ser 
        675                 680                 685             


Gln Pro Ala Gly Pro Ala Ser Leu Arg Ala Glu Tyr Leu Pro Pro Ser 
    690                 695                 700                 


Val Ala Ser Ile Lys Val Ser Ala Glu Leu Leu Arg Ala Ala Leu Lys 
705                 710                 715                 720 


Asp Gly His Ser Gly Val Pro Leu Cys Cys Ala Thr Leu Gln Trp Leu 
                725                 730                 735     


Leu Ala Glu Asn Ala Ala Val Asp Val Val Arg Ala Arg Ala Leu Ser 
            740                 745                 750         


Ser Ile Gln Gly Val Ala Pro Asp Gly Ala Asn Val His Leu Ile Val 
        755                 760                 765             


Arg Glu Val Ala Met Thr Asp Leu Cys Pro Ala Gly Pro Ile Gln Ala 
    770                 775                 780                 


Val Glu Ile Gln Val Glu Ser Ser Ser Leu Ala Asp Ile Cys Arg Ala 
785                 790                 795                 800 


His His Ala Val Val Gly Arg Met Gln Thr Met Val Thr Glu Gln Ala 
                805                 810                 815     


Thr Gln Gly Ser Ser Ala Pro Asp Leu Arg Val Gln Tyr Leu Arg Gln 
            820                 825                 830         


Ile His Ala Asn His Glu Thr Leu Leu Arg Glu Val Gln Thr Leu Arg 
        835                 840                 845             


Asp Arg Leu Cys Thr Glu Asp Glu Ala Ser Ser Cys Ala Thr Ala Gln 
    850                 855                 860                 


Arg Leu Leu Gln Val Tyr Arg Gln Leu Arg His Pro Ser Leu Ile Leu 
865                 870                 875                 880 


Leu 
    


<210> 5508
<211> 156
<212> PRT
<213> Homo sapiens

<400> 5508
Met Gly Asp Lys Lys Ser Pro Thr Arg Pro Lys Arg Gln Pro Lys Pro 
1               5                   10                  15      


Ser Ser Asp Glu Gly Tyr Trp Asp Cys Ser Val Cys Thr Phe Arg Asn 
            20                  25                  30          


Ser Ala Glu Ala Phe Lys Cys Met Met Cys Asp Val Arg Lys Gly Thr 
        35                  40                  45              


Ser Thr Arg Lys Glu Lys Lys Asp Lys Val Glu Lys Glu Lys Ser Glu 
    50                  55                  60                  


Lys Glu Thr Thr Ser Lys Lys Asn Ser His Lys Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Leu Lys Asn Val Asp Arg Ser Ser Ala Gln His Leu Glu Val Thr Val 
                85                  90                  95      


Gly Asp Leu Thr Val Ile Ile Thr Asp Phe Lys Glu Lys Thr Lys Ser 
            100                 105                 110         


Pro Pro Ala Ser Ser Ala Ala Ser Ala Asp Gln His Ser Gln Ser Gly 
        115                 120                 125             


Ser Ser Ser Asp Asn Thr Glu Arg Gly Met Ser Arg Ser Ser Ser Pro 
    130                 135                 140                 


Arg Gly Glu Ala Ser Ser Leu Asn Gly Glu Ser His 
145                 150                 155     


<210> 5509
<211> 258
<212> PRT
<213> Homo sapiens

<400> 5509
Met Cys Ala Leu Glu Met Ala Val Leu Glu Ile Gln Thr Asn Gly Asp 
1               5                   10                  15      


Thr Arg Val Thr Glu Glu Ala Ile Ala Arg Ala Arg His Ser Leu Ser 
            20                  25                  30          


Asp Pro Asn Met Arg Glu Phe Ile Leu Cys Cys Leu Ala Arg Asp Pro 
        35                  40                  45              


Ala Arg Arg Pro Ser Ala His Ser Leu Leu Phe His Arg Val Leu Phe 
    50                  55                  60                  


Glu Val His Ser Leu Lys Leu Leu Ala Ala His Cys Phe Ile Gln His 
65                  70                  75                  80  


Gln Tyr Leu Met Pro Glu Asn Val Val Glu Glu Lys Thr Lys Ala Met 
                85                  90                  95      


Asp Leu His Ala Val Leu Ala Glu Leu Pro Arg Pro Arg Arg Pro Pro 
            100                 105                 110         


Leu Gln Trp Arg Tyr Ser Glu Val Ser Phe Met Glu Leu Asp Lys Phe 
        115                 120                 125             


Leu Glu Asp Val Arg Asn Gly Ile Tyr Pro Leu Met Asn Phe Ala Ala 
    130                 135                 140                 


Thr Arg Pro Leu Gly Leu Pro Arg Val Leu Ala Pro Pro Pro Glu Glu 
145                 150                 155                 160 


Val Gln Lys Ala Lys Thr Pro Thr Pro Glu Pro Phe Asp Ser Glu Thr 
                165                 170                 175     


Arg Lys Val Ile Gln Met Gln Cys Asn Leu Glu Arg Ser Glu Asp Lys 
            180                 185                 190         


Ala Arg Trp His Leu Thr Leu Leu Leu Val Leu Glu Asp Arg Leu His 
        195                 200                 205             


Arg Gln Leu Thr Tyr Asp Leu Leu Pro Thr Asp Ser Ala Gln Asp Leu 
    210                 215                 220                 


Ala Ser Glu Leu Val His Tyr Gly Phe Leu His Glu Asp Asp Arg Met 
225                 230                 235                 240 


Lys Leu Ala Ala Phe Leu Glu Ser Thr Phe Leu Lys Tyr Arg Gly Thr 
                245                 250                 255     


Gln Ala 
        


<210> 5510
<211> 187
<212> PRT
<213> Homo sapiens

<400> 5510
Met Leu Gly Arg Tyr Arg Glu Tyr Ser Asn Gly Gln Ala Gly Ala Ile 
1               5                   10                  15      


Glu His Leu Lys Glu Ser Leu Glu Gln Ser Ile Asp Gln Leu Arg Ser 
            20                  25                  30          


Gln Arg Leu Leu Arg Asn Ser Gly Gly Arg Ser Ile Ser Val Thr Ser 
        35                  40                  45              


Leu Ser Ala Ser Asp Leu Asp Gly Gly Thr Gly Ser Glu Leu His His 
    50                  55                  60                  


Phe Pro Pro Thr Ser Pro Leu Lys Asp Tyr Gly Asp Pro Gln Gly Ile 
65                  70                  75                  80  


Lys Arg Met Arg Ser Arg Thr Gly Val Arg Phe Val Gln Glu Thr Asp 
                85                  90                  95      


Asp Met Thr Gln Leu His Gly Phe His Gln Ser Leu Arg Asp Leu Ser 
            100                 105                 110         


Ser Glu Gln Ile Arg Leu Gly Asp Asp Phe Asn Arg Glu Leu Ser Arg 
        115                 120                 125             


Arg Ser Arg Ser Asp Ala Glu Thr Lys Arg Ala Leu Glu Glu Leu Thr 
    130                 135                 140                 


Glu Lys Leu Asn Glu Ala Gln Lys Gln Glu Val Phe Phe Val Lys Ser 
145                 150                 155                 160 


Leu Gly Lys Val Lys Ile Gln Cys Leu Ser Ser Ala Glu Val Asp Asn 
                165                 170                 175     


Val Phe Pro Ile Asn Val Trp Gln Cys Gly Ile 
            180                 185         


<210> 5511
<211> 308
<212> PRT
<213> Homo sapiens

<400> 5511
Met Met Asp Val Ser Gly Val Gly Phe Pro Ser Lys Val Pro Trp Lys 
1               5                   10                  15      


Lys Met Ser Ala Glu Glu Leu Glu Asn Gln Tyr Cys Pro Ser Arg Trp 
            20                  25                  30          


Val Val Arg Leu Gly Ala Glu Glu Ala Leu Arg Thr Tyr Ser Gln Ile 
        35                  40                  45              


Gly Ile Glu Ala Thr Thr Arg Ala Arg Ala Thr Arg Lys Ser Leu Leu 
    50                  55                  60                  


His Val Pro Tyr Gly Asp Gly Glu Gly Glu Lys Val Asp Ile Tyr Phe 
65                  70                  75                  80  


Pro Asp Glu Ser Ser Glu Ala Leu Pro Phe Phe Leu Phe Phe His Gly 
                85                  90                  95      


Gly Tyr Trp Gln Ser Gly Ser Lys Asp Glu Ser Ala Phe Met Val His 
            100                 105                 110         


Pro Leu Thr Ala Gln Gly Val Ala Val Val Ile Val Ala Tyr Gly Ile 
        115                 120                 125             


Ala Pro Lys Gly Thr Leu Asp His Met Val Asp Gln Val Thr Arg Ser 
    130                 135                 140                 


Val Ala Phe Val Gln Lys Arg Tyr Pro Ser Asn Lys Gly Ile Tyr Leu 
145                 150                 155                 160 


Cys Gly His Ser Ala Gly Ala His Leu Ala Ala Met Met Leu Leu Ala 
                165                 170                 175     


Asp Trp Thr Lys His Gly Val Thr Pro Asn Leu Arg Gly Phe Phe Leu 
            180                 185                 190         


Val Ser Gly Val Phe Asp Leu Glu Pro Ile Val Tyr Thr Ser Gln Asn 
        195                 200                 205             


Val Ala Leu Gln Leu Thr Leu Glu Asp Ala Gln Arg Asn Ser Pro Gln 
    210                 215                 220                 


Leu Lys Val Ala Gln Ala Gln Pro Val Asp Pro Thr Cys Arg Val Leu 
225                 230                 235                 240 


Val Val Val Gly Gln Phe Asp Ser Pro Glu Phe His Arg Gln Ser Trp 
                245                 250                 255     


Glu Phe Tyr Gln Val Leu Pro Val Gln Thr Leu Cys Gln Gly Glu Trp 
            260                 265                 270         


Lys Ala Ser Phe Glu Glu Leu His Asp Val Asp His Phe Glu Ile Val 
        275                 280                 285             


Glu Asn Leu Thr Gln Lys Asp Asn Val Leu Thr Gln Ile Ile Leu Lys 
    290                 295                 300                 


Thr Ile Phe Gln 
305             


<210> 5512
<211> 486
<212> PRT
<213> Homo sapiens

<400> 5512
Met Ser Gly Ser Thr Pro Phe Gln Met Arg Leu Val His Leu Asp Leu 
1               5                   10                  15      


Lys Gly Ala Pro Pro Lys Val Ser Tyr Leu Ser Glu Ile Phe Pro Leu 
            20                  25                  30          


Phe Arg Ala Leu Gly Ala Asn Gly Leu Leu Ile Glu Tyr Glu Asp Met 
        35                  40                  45              


Phe Pro Tyr Glu Gly Pro Leu Arg Leu Leu Arg Ala Lys Tyr Ala Tyr 
    50                  55                  60                  


Ser Pro Ser Glu Ile Lys Glu Ile Leu His Leu Ala Gly Leu Asn Glu 
65                  70                  75                  80  


Leu Glu Val Ile Pro Leu Val Gln Thr Phe Gly His Met Glu Phe Val 
                85                  90                  95      


Leu Lys His Thr Ala Phe Ala His Leu Arg Glu Val Gly Ser Phe Pro 
            100                 105                 110         


Cys Thr Leu Asn Pro His Glu Ala Glu Ser Leu Ala Leu Val Gly Ala 
        115                 120                 125             


Met Ile Asp Gln Val Leu Glu Leu His Pro Gly Ala Gln Arg Leu His 
    130                 135                 140                 


Ile Gly Cys Asp Glu Val Tyr Tyr Leu Gly Glu Gly Glu Ala Ser Arg 
145                 150                 155                 160 


Arg Trp Leu Gln Gln Glu Gln Asn Ser Thr Gly Lys Leu Cys Leu Ser 
                165                 170                 175     


His Met Arg Ala Val Ala Ser Gly Val Lys Ala Arg Arg Pro Ser Val 
            180                 185                 190         


Thr Pro Leu Val Trp Asp Asp Met Leu Arg Asp Leu Pro Glu Asp Gln 
        195                 200                 205             


Leu Ala Ala Ser Gly Val Pro Gln Leu Val Glu Pro Val Leu Trp Asp 
    210                 215                 220                 


Tyr Thr Ala Asp Leu Asp Val His Gly Lys Val Leu Leu Met Gln Lys 
225                 230                 235                 240 


Tyr Arg Arg Cys Gly Phe Pro Gln Leu Trp Ala Ala Ser Ala Phe Lys 
                245                 250                 255     


Gly Ala Thr Gly Pro Ser Gln Ala Val Pro Pro Val Glu His His Leu 
            260                 265                 270         


Arg Asn His Val Gln Trp Leu Gln Val Ala Gly Ser Gly Pro Thr Asp 
        275                 280                 285             


Ser Leu Gln Gly Ile Ile Leu Thr Gly Trp Gln Arg Tyr Asp His Tyr 
    290                 295                 300                 


Ser Val Leu Cys Glu Leu Leu Pro Ala Gly Val Pro Ser Leu Ala Ala 
305                 310                 315                 320 


Cys Leu Gln Leu Leu Leu Arg Gly Gly Phe Asp Glu Asp Val Lys Ala 
                325                 330                 335     


Lys Val Glu Asn Leu Leu Gly Ile Ser Ser Leu Glu Lys Thr Asp Pro 
            340                 345                 350         


Val Arg Glu Gly Ala Gly Ser Phe Pro Gly Ser Asn Ile Leu Ala Leu 
        355                 360                 365             


Val Thr Gln Val Ser Leu His Leu Arg Ser Ser Val Asp Ala Leu Leu 
    370                 375                 380                 


Glu Gly Asn Arg Tyr Val Thr Gly Trp Phe Ser Pro Tyr His Arg Gln 
385                 390                 395                 400 


Arg Lys Leu Ile His Pro Val Met Val Gln His Ile Gln Pro Ala Ala 
                405                 410                 415     


Leu Ser Leu Leu Ala Gln Trp Ser Thr Leu Val Gln Glu Leu Glu Ala 
            420                 425                 430         


Ala Leu Gln Leu Ala Phe Tyr Pro Asp Ala Val Glu Glu Trp Leu Glu 
        435                 440                 445             


Glu Asn Val His Pro Ser Leu Gln Arg Leu Gln Ala Leu Leu Gln Asp 
    450                 455                 460                 


Leu Ser Glu Val Ser Ala Pro Pro Leu Pro Pro Thr Ser Pro Gly Arg 
465                 470                 475                 480 


Asp Val Ala Gln Asp Pro 
                485     


<210> 5513
<211> 79
<212> PRT
<213> Homo sapiens

<400> 5513
Met Ser Ser Gln Gln Gln Gln Arg Gln Gln Gln Gln Cys Pro Pro Gln 
1               5                   10                  15      


Arg Ala Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Val 
            20                  25                  30          


Lys Cys Gln Glu Thr Cys Ala Pro Lys Thr Lys Asp Pro Cys Ala Pro 
        35                  40                  45              


Gln Val Lys Lys Gln Cys Pro Pro Lys Gly Thr Ile Ile Pro Ala Gln 
    50                  55                  60                  


Gln Lys Cys Pro Ser Ala Gln Gln Ala Ser Lys Ser Lys Gln Lys 
65                  70                  75                  


<210> 5514
<211> 273
<212> PRT
<213> Homo sapiens

<400> 5514
Met Gly Gln Lys Val Thr Gly Gly Ile Lys Thr Val Asp Met Arg Asp 
1               5                   10                  15      


Pro Thr Tyr Arg Pro Leu Lys Gln Glu Leu Gln Gly Leu Asp Tyr Cys 
            20                  25                  30          


Lys Pro Thr Arg Leu Asp Leu Leu Leu Asp Met Pro Pro Val Ser Tyr 
        35                  40                  45              


Asp Val Gln Leu Leu His Ser Trp Asn Asn Asn Asp Arg Ser Leu Asn 
    50                  55                  60                  


Val Phe Val Lys Glu Asp Asp Lys Leu Ile Phe His Arg His Pro Val 
65                  70                  75                  80  


Ala Gln Ser Thr Asp Ala Ile Arg Gly Lys Val Gly Tyr Thr Arg Gly 
                85                  90                  95      


Leu His Val Trp Gln Ile Thr Trp Ala Met Arg Gln Arg Gly Thr His 
            100                 105                 110         


Ala Val Val Gly Val Ala Thr Ala Asp Ala Pro Leu His Ser Val Gly 
        115                 120                 125             


Tyr Thr Thr Leu Val Gly Asn Asn His Glu Ser Trp Gly Trp Asp Leu 
    130                 135                 140                 


Gly Arg Asn Arg Leu Tyr His Asp Gly Lys Asn Gln Pro Ser Lys Thr 
145                 150                 155                 160 


Tyr Pro Ala Phe Leu Glu Pro Asp Glu Thr Phe Ile Val Pro Asp Ser 
                165                 170                 175     


Phe Leu Val Ala Leu Asp Met Asp Asp Gly Thr Leu Ser Phe Ile Val 
            180                 185                 190         


Asp Gly Gln Tyr Met Gly Val Ala Phe Arg Gly Leu Lys Gly Lys Lys 
        195                 200                 205             


Leu Tyr Pro Val Val Ser Ala Val Trp Gly His Cys Glu Ile Arg Met 
    210                 215                 220                 


Arg Tyr Leu Asn Gly Leu Asp Pro Glu Pro Leu Pro Leu Met Asp Leu 
225                 230                 235                 240 


Cys Arg Arg Ser Val Arg Leu Ala Leu Gly Arg Glu Arg Leu Gly Glu 
                245                 250                 255     


Ile His Thr Leu Pro Leu Pro Ala Ser Leu Lys Ala Tyr Leu Leu Tyr 
            260                 265                 270         


Gln 
    


<210> 5515
<211> 1104
<212> PRT
<213> Homo sapiens

<400> 5515
Met Gly Asn Ala Ala Gly Ser Ala Glu Gln Pro Ala Gly Pro Ala Ala 
1               5                   10                  15      


Pro Pro Pro Lys Gln Pro Ala Pro Pro Lys Gln Pro Met Pro Ala Ala 
            20                  25                  30          


Gly Glu Leu Glu Glu Arg Phe Asn Arg Ala Leu Asn Cys Met Asn Leu 
        35                  40                  45              


Pro Pro Asp Lys Val Gln Leu Leu Ser Gln Tyr Asp Asn Glu Lys Lys 
    50                  55                  60                  


Trp Glu Leu Ile Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro 
65                  70                  75                  80  


Ala Ala Tyr Ile Gln Lys Leu Lys Ser Tyr Val Asp Thr Gly Gly Val 
                85                  90                  95      


Ser Arg Lys Val Ala Ala Asp Trp Met Ser Asn Leu Gly Phe Lys Arg 
            100                 105                 110         


Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Thr Ser Leu 
        115                 120                 125             


Arg Thr Asn His Ile Gly Trp Val Gln Glu Phe Leu Asn Glu Glu Asn 
    130                 135                 140                 


Arg Gly Leu Asp Val Leu Leu Glu Tyr Leu Ala Phe Ala Gln Cys Ser 
145                 150                 155                 160 


Val Thr Tyr Asp Met Glu Ser Thr Asp Asn Gly Ala Ser Asn Ser Glu 
                165                 170                 175     


Lys Asn Lys Pro Leu Glu Gln Ser Val Glu Asp Leu Ser Lys Gly Pro 
            180                 185                 190         


Pro Ser Ser Val Pro Lys Ser Arg His Leu Thr Ile Lys Leu Thr Pro 
        195                 200                 205             


Ala His Ser Arg Lys Ala Leu Arg Asn Ser Arg Ile Val Ser Gln Lys 
    210                 215                 220                 


Asp Asp Val His Val Cys Ile Met Cys Leu Arg Ala Ile Met Asn Tyr 
225                 230                 235                 240 


Gln Ser Gly Phe Ser Leu Val Met Asn His Pro Ala Cys Val Asn Glu 
                245                 250                 255     


Ile Ala Leu Ser Leu Asn Asn Lys Asn Pro Arg Thr Lys Ala Leu Val 
            260                 265                 270         


Leu Glu Leu Leu Ala Ala Val Cys Leu Val Arg Gly Gly His Asp Ile 
        275                 280                 285             


Ile Leu Ala Ala Phe Asp Asn Phe Lys Glu Val Cys Gly Glu Gln His 
    290                 295                 300                 


Arg Phe Glu Lys Leu Met Glu Tyr Phe Arg Asn Glu Asp Ser Asn Ile 
305                 310                 315                 320 


Asp Phe Met Val Ala Cys Met Gln Phe Ile Asn Ile Val Val His Ser 
                325                 330                 335     


Val Glu Asn Met Asn Phe Arg Val Phe Leu Gln Tyr Glu Phe Thr His 
            340                 345                 350         


Leu Gly Leu Asp Leu Tyr Leu Glu Arg Leu Arg Leu Thr Glu Ser Asp 
        355                 360                 365             


Lys Leu Gln Val Gln Ile Gln Ala Tyr Leu Asp Asn Ile Phe Asp Val 
    370                 375                 380                 


Gly Ala Leu Leu Glu Asp Thr Glu Thr Lys Asn Ala Val Leu Glu His 
385                 390                 395                 400 


Met Glu Glu Leu Gln Glu Gln Val Ala Leu Leu Thr Glu Arg Leu Arg 
                405                 410                 415     


Asp Ala Glu Asn Glu Ser Met Ala Lys Ile Ala Glu Leu Glu Lys Gln 
            420                 425                 430         


Leu Ser Gln Ala Arg Lys Glu Leu Glu Thr Leu Arg Glu Arg Phe Ser 
        435                 440                 445             


Glu Ser Thr Ala Met Gly Pro Ser Arg Arg Pro Pro Glu Pro Glu Lys 
    450                 455                 460                 


Ala Pro Pro Ala Ala Pro Thr Arg Pro Ser Ala Leu Glu Leu Lys Val 
465                 470                 475                 480 


Glu Glu Leu Glu Glu Lys Gly Leu Ile Arg Ile Leu Arg Gly Pro Gly 
                485                 490                 495     


Asp Ala Val Ser Ile Glu Ile Leu Pro Val Ala Val Ala Thr Pro Ser 
            500                 505                 510         


Gly Gly Asp Ala Pro Thr Pro Gly Val Pro Thr Gly Ser Pro Ser Pro 
        515                 520                 525             


Asp Leu Ala Pro Ala Ala Glu Pro Ala Pro Gly Ala Ala Pro Pro Pro 
    530                 535                 540                 


Pro Pro Pro Leu Pro Gly Leu Pro Ser Pro Gln Glu Ala Pro Pro Ser 
545                 550                 555                 560 


Ala Pro Pro Gln Ala Pro Pro Leu Pro Gly Ser Pro Glu Pro Pro Pro 
                565                 570                 575     


Ala Pro Pro Leu Pro Gly Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            580                 585                 590         


Pro Pro Pro Gly Thr Asp Gly Pro Val Pro Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Pro Pro Pro Pro Gly Gly Pro Pro Asp Ala Leu Gly Arg Arg Asp Ser 
    610                 615                 620                 


Glu Leu Gly Pro Gly Val Lys Ala Lys Lys Pro Ile Gln Thr Lys Phe 
625                 630                 635                 640 


Arg Met Pro Leu Leu Asn Trp Val Ala Leu Lys Pro Ser Gln Ile Thr 
                645                 650                 655     


Gly Thr Val Phe Thr Glu Leu Asn Asp Glu Lys Val Leu Gln Glu Leu 
            660                 665                 670         


Asp Met Ser Asp Phe Glu Glu Gln Phe Lys Thr Lys Ser Gln Gly Pro 
        675                 680                 685             


Ser Leu Asp Leu Ser Ala Leu Lys Ser Lys Ala Ala Gln Lys Ala Pro 
    690                 695                 700                 


Ser Lys Ala Thr Leu Ile Glu Ala Asn Arg Ala Lys Asn Leu Ala Ile 
705                 710                 715                 720 


Thr Leu Arg Lys Gly Asn Leu Gly Ala Glu Arg Ile Cys Gln Ala Ile 
                725                 730                 735     


Glu Ala Tyr Asp Leu Gln Ala Leu Gly Leu Asp Phe Leu Glu Leu Leu 
            740                 745                 750         


Met Arg Phe Leu Pro Thr Glu Tyr Glu Arg Ser Leu Ile Thr Arg Phe 
        755                 760                 765             


Glu Arg Glu Gln Arg Pro Met Glu Glu Leu Ser Glu Glu Asp Arg Phe 
    770                 775                 780                 


Met Leu Cys Phe Ser Arg Ile Pro Arg Leu Pro Glu Arg Met Thr Thr 
785                 790                 795                 800 


Leu Thr Phe Leu Gly Asn Phe Pro Asp Thr Ala Gln Leu Leu Met Pro 
                805                 810                 815     


Gln Leu Asn Ala Ile Ile Ala Ala Ser Met Ser Ile Lys Ser Ser Asp 
            820                 825                 830         


Lys Leu Arg Gln Ile Leu Glu Ile Val Leu Ala Phe Gly Asn Tyr Met 
        835                 840                 845             


Asn Ser Ser Lys Arg Gly Ala Ala Tyr Gly Phe Arg Leu Gln Ser Leu 
    850                 855                 860                 


Asp Ala Leu Leu Glu Met Lys Ser Thr Asp Arg Lys Gln Thr Leu Leu 
865                 870                 875                 880 


His Tyr Leu Val Lys Val Ile Ala Glu Lys Tyr Pro Gln Leu Thr Gly 
                885                 890                 895     


Phe His Ser Asp Leu His Phe Leu Asp Lys Ala Gly Ser Val Ser Leu 
            900                 905                 910         


Asp Ser Val Leu Ala Asp Val Arg Ser Leu Gln Arg Gly Leu Glu Leu 
        915                 920                 925             


Thr Gln Arg Glu Phe Val Arg Gln Asp Asp Cys Met Val Leu Lys Glu 
    930                 935                 940                 


Phe Leu Arg Ala Asn Ser Pro Thr Met Asp Lys Leu Leu Ala Asp Ser 
945                 950                 955                 960 


Lys Thr Ala Gln Glu Ala Phe Glu Ser Val Val Glu Tyr Phe Gly Glu 
                965                 970                 975     


Asn Pro Lys Thr Thr Ser Pro Gly Leu Phe Phe Ser Leu Phe Ser Arg 
            980                 985                 990         


Phe Ile Lys Ala Tyr Lys Lys Ala  Glu Gln Glu Val Glu  Gln Trp Lys 
        995                 1000                 1005             


Lys Glu  Ala Ala Ala Gln Glu  Ala Gly Ala Asp Thr  Pro Gly Lys 
    1010                 1015                 1020             


Gly Glu  Pro Pro Ala Pro Lys  Ser Pro Pro Lys Ala  Arg Arg Pro 
    1025                 1030                 1035             


Gln Met  Asp Leu Ile Ser Glu  Leu Lys Arg Arg Gln  Gln Lys Glu 
    1040                 1045                 1050             


Pro Leu  Ile Tyr Glu Ser Asp  Arg Asp Gly Ala Ile  Glu Asp Ile 
    1055                 1060                 1065             


Ile Thr  Asp Leu Arg Asn Gln  Pro Tyr Ile Arg Ala  Asp Thr Gly 
    1070                 1075                 1080             


Arg Arg  Ser Ala Arg Arg Arg  Pro Pro Gly Pro Pro  Leu Gln Val 
    1085                 1090                 1095             


Thr Ser  Asp Leu Ser Leu 
    1100                 


<210> 5516
<211> 200
<212> PRT
<213> Homo sapiens

<400> 5516
Met Glu Glu Lys Pro Ser Lys Val Ser Leu Lys Ser Ser Asp Arg Gln 
1               5                   10                  15      


Gly Ser Asp Glu Glu Ser Val His Ser Asp Thr Arg Asp Leu Trp Thr 
            20                  25                  30          


Thr Thr Thr Leu Ser Gln Ala Gln Leu Asn Met Pro Leu Ser Glu Val 
        35                  40                  45              


Cys Glu Gly Phe Asp Glu Glu Gly Arg Asn Ile Ser Lys Thr Arg Gly 
    50                  55                  60                  


Trp His Ser Pro Gly Arg Gly Ser Leu Asp Glu Gly Tyr Lys Ala Ser 
65                  70                  75                  80  


His Lys Pro Glu Glu Leu Asp Glu His Ala Leu Val Glu Leu Glu Leu 
                85                  90                  95      


His Arg Gly Ser Ser Met Glu Ile Asn Leu Gly Glu Lys Asp Thr Ala 
            100                 105                 110         


Ser Gln Ile Glu Ala Glu Lys Ser Ser Ser Met Ser Ser Leu Asn Ile 
        115                 120                 125             


Ala Lys His Met Pro His Arg Ala Tyr Trp Ala Glu Gln Gln Ser Arg 
    130                 135                 140                 


Leu Pro Leu Pro Leu Met Glu Leu Met Glu Asn Glu Ala Leu Glu Ile 
145                 150                 155                 160 


Leu Thr Lys Ala Leu Arg Ser Tyr Gln Leu Gly Ile Gly Arg Asp His 
                165                 170                 175     


Phe Leu Thr Lys Glu Leu Gln Arg Tyr Ile Glu Gly Leu Lys Lys Arg 
            180                 185                 190         


Arg Ser Lys Arg Leu Tyr Val Asn 
        195                 200 


<210> 5517
<211> 347
<212> PRT
<213> Homo sapiens

<400> 5517
Met Lys Leu Thr Ser Glu Lys Leu Pro Lys Asn Pro Phe Tyr Ala Ser 
1               5                   10                  15      


Val Ser Gln Tyr Ala Ala Lys Asn Gln Lys Phe Phe Gln Trp Lys Lys 
            20                  25                  30          


Glu Lys Thr Asp Tyr Thr His Ala Asn Leu Val Asp Lys Ala Leu Gln 
        35                  40                  45              


Leu Leu Lys Glu Arg Ile Leu Lys Gly Asp Thr Leu Ala Tyr Phe Leu 
    50                  55                  60                  


Arg Gly Gln Leu Tyr Phe Glu Glu Gly Trp Tyr Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Gln Phe Glu Glu Ile Lys Glu Lys Asp His Gln Ala Thr Tyr Gln Leu 
                85                  90                  95      


Gly Val Met Tyr Tyr Asp Gly Leu Gly Thr Thr Leu Asp Ala Glu Lys 
            100                 105                 110         


Gly Val Asp Tyr Met Lys Lys Ile Leu Asp Ser Pro Cys Pro Lys Ala 
        115                 120                 125             


Arg His Leu Lys Phe Ala Ala Ala Tyr Asn Leu Gly Arg Ala Tyr Tyr 
    130                 135                 140                 


Glu Gly Lys Gly Val Lys Arg Ser Asn Glu Glu Ala Glu Arg Leu Trp 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Asn Gly Asn Pro Lys Ala Ser Val Lys Ala Gln 
                165                 170                 175     


Ser Met Leu Gly Leu Tyr Tyr Ser Thr Lys Glu Pro Lys Glu Leu Glu 
            180                 185                 190         


Lys Ala Phe Tyr Trp His Ser Glu Ala Cys Gly Asn Gly Asn Leu Glu 
        195                 200                 205             


Ser Gln Gly Ala Leu Gly Leu Met Tyr Leu Tyr Gly Gln Gly Ile Arg 
    210                 215                 220                 


Gln Asp Thr Glu Ala Ala Leu Gln Cys Leu Arg Glu Ala Ala Glu Arg 
225                 230                 235                 240 


Gly Asn Val Tyr Ala Gln Gly Asn Leu Val Glu Tyr Tyr Tyr Lys Met 
                245                 250                 255     


Lys Phe Phe Thr Lys Cys Val Ala Phe Ser Lys Arg Ile Ala Asp Tyr 
            260                 265                 270         


Asp Glu Val His Asp Ile Pro Met Ile Ala Gln Val Thr Asp Cys Leu 
        275                 280                 285             


Pro Glu Phe Ile Gly Arg Gly Met Ala Met Ala Ser Phe Tyr His Ala 
    290                 295                 300                 


Arg Cys Leu Gln Leu Gly Leu Gly Ile Thr Arg Asp Glu Thr Thr Ala 
305                 310                 315                 320 


Lys His Tyr Tyr Ser Lys Ala Cys Arg Leu Asn Pro Ala Leu Ala Asp 
                325                 330                 335     


Glu Leu His Ser Leu Leu Ile Arg Gln Arg Ile 
            340                 345         


<210> 5518
<211> 1174
<212> PRT
<213> Homo sapiens

<400> 5518
Met Pro Leu Pro Phe Gly Leu Lys Leu Lys Arg Thr Arg Arg Tyr Thr 
1               5                   10                  15      


Val Ser Ser Lys Ser Cys Leu Val Ala Arg Ile Gln Leu Leu Asn Asn 
            20                  25                  30          


Glu Phe Val Glu Phe Thr Leu Ser Val Glu Ser Thr Gly Gln Glu Ser 
        35                  40                  45              


Leu Glu Ala Val Ala Gln Arg Leu Glu Leu Arg Glu Val Thr Tyr Phe 
    50                  55                  60                  


Ser Leu Trp Tyr Tyr Asn Lys Gln Asn Gln Arg Arg Trp Val Asp Leu 
65                  70                  75                  80  


Glu Lys Pro Leu Lys Lys Gln Leu Asp Lys Tyr Ala Leu Glu Pro Thr 
                85                  90                  95      


Val Tyr Phe Gly Val Val Phe Tyr Val Pro Ser Val Ser Gln Leu Gln 
            100                 105                 110         


Gln Glu Ile Thr Arg Tyr Gln Tyr Tyr Leu Gln Leu Lys Lys Asp Ile 
        115                 120                 125             


Leu Glu Gly Ser Ile Pro Cys Thr Leu Glu Gln Ala Ile Gln Leu Ala 
    130                 135                 140                 


Gly Leu Ala Val Gln Ala Asp Phe Gly Asp Phe Asp Gln Tyr Glu Ser 
145                 150                 155                 160 


Gln Asp Phe Leu Gln Lys Phe Ala Leu Phe Pro Val Gly Trp Leu Gln 
                165                 170                 175     


Asp Glu Lys Val Leu Glu Glu Ala Thr Gln Lys Val Ala Leu Leu His 
            180                 185                 190         


Gln Lys Tyr Arg Gly Leu Thr Ala Pro Asp Ala Glu Met Leu Tyr Met 
        195                 200                 205             


Gln Glu Val Glu Arg Met Asp Gly Tyr Gly Glu Glu Ser Tyr Pro Ala 
    210                 215                 220                 


Lys Asp Ser Gln Gly Ser Asp Ile Ser Ile Gly Ala Cys Leu Glu Gly 
225                 230                 235                 240 


Ile Phe Val Lys His Lys Asn Gly Arg His Pro Val Val Phe Arg Trp 
                245                 250                 255     


His Asp Ile Ala Asn Met Ser His Asn Lys Ser Phe Phe Ala Leu Glu 
            260                 265                 270         


Leu Ala Asn Lys Glu Glu Thr Ile Gln Phe Gln Thr Glu Asp Met Glu 
        275                 280                 285             


Thr Ala Lys Tyr Ile Trp Arg Leu Cys Val Ala Arg His Lys Phe Tyr 
    290                 295                 300                 


Arg Leu Asn Gln Cys Asn Leu Gln Thr Gln Thr Val Thr Val Asn Pro 
305                 310                 315                 320 


Ile Arg Arg Arg Ser Ser Ser Arg Met Ser Leu Pro Lys Pro Gln Pro 
                325                 330                 335     


Tyr Val Met Pro Pro Pro Pro Gln Leu His Tyr Asn Gly His Tyr Thr 
            340                 345                 350         


Glu Pro Tyr Ala Ser Ser Gln Asp Asn Leu Phe Val Pro Asn Gln Asn 
        355                 360                 365             


Gly Tyr Tyr Cys His Ser Gln Thr Ser Leu Asp Arg Ala Gln Ile Asp 
    370                 375                 380                 


Leu Asn Gly Arg Ile Arg Asn Gly Ser Val Tyr Ser Ala His Ser Thr 
385                 390                 395                 400 


Asn Ser Leu Asn Asn Pro Gln Pro Tyr Leu Gln Pro Ser Pro Met Ser 
                405                 410                 415     


Ser Asn Pro Ser Ile Thr Gly Ser Asp Val Met Arg Pro Asp Tyr Leu 
            420                 425                 430         


Pro Ser His Arg His Ser Ala Val Ile Pro Pro Ser Tyr Arg Pro Thr 
        435                 440                 445             


Pro Asp Tyr Glu Thr Val Met Lys Gln Leu Asn Arg Gly Leu Val His 
    450                 455                 460                 


Ala Glu Arg Gln Ser His Ser Leu Arg Asn Leu Asn Ile Gly Ser Ser 
465                 470                 475                 480 


Tyr Ala Tyr Ser Arg Pro Ala Ala Leu Val Tyr Ser Gln Pro Glu Ile 
                485                 490                 495     


Arg Glu His Ala Gln Leu Pro Ser Pro Ala Ala Ala His Cys Pro Phe 
            500                 505                 510         


Ser Leu Ser Tyr Ser Phe His Ser Pro Ser Pro Tyr Pro Tyr Pro Ala 
        515                 520                 525             


Glu Arg Arg Pro Val Val Gly Ala Val Ser Val Pro Glu Leu Thr Asn 
    530                 535                 540                 


Ala Gln Leu Gln Ala Gln Asp Tyr Pro Ser Pro Asn Ile Met Arg Thr 
545                 550                 555                 560 


Gln Val Tyr Arg Pro Pro Pro Pro Tyr Pro Pro Pro Arg Pro Ala Asn 
                565                 570                 575     


Ser Thr Pro Asp Leu Ser Arg His Leu Tyr Ile Ser Ser Ser Asn Pro 
            580                 585                 590         


Asp Leu Ile Thr Arg Arg Val His His Ser Val Gln Thr Phe Gln Glu 
        595                 600                 605             


Asp Ser Leu Pro Val Ala His Ser Leu Gln Glu Val Ser Glu Pro Leu 
    610                 615                 620                 


Thr Ala Ala Arg His Ala Gln Leu His Lys Arg Asn Ser Ile Glu Val 
625                 630                 635                 640 


Ala Gly Leu Ser His Gly Leu Glu Gly Leu Arg Leu Lys Glu Arg Thr 
                645                 650                 655     


Leu Ser Ala Ser Ala Ala Glu Val Ala Pro Arg Ala Val Ser Val Gly 
            660                 665                 670         


Ser Gln Pro Ser Val Phe Thr Glu Arg Thr Gln Arg Glu Gly Pro Glu 
        675                 680                 685             


Glu Ala Glu Gly Leu Arg Tyr Gly His Lys Lys Ser Leu Ser Asp Ala 
    690                 695                 700                 


Thr Met Leu Ile His Ser Ser Glu Glu Glu Glu Asp Glu Asp Phe Glu 
705                 710                 715                 720 


Glu Glu Ser Gly Ala Arg Ala Pro Pro Ala Arg Ala Arg Glu Pro Arg 
                725                 730                 735     


Pro Gly Leu Ala Gln Asp Pro Pro Gly Cys Pro Arg Val Leu Leu Ala 
            740                 745                 750         


Gly Pro Leu His Ile Leu Glu Pro Lys Ala His Val Pro Asp Ala Glu 
        755                 760                 765             


Lys Arg Met Met Asp Ser Ser Pro Val Arg Thr Thr Ala Glu Ala Gln 
    770                 775                 780                 


Arg Pro Trp Arg Asp Gly Leu Leu Met Pro Ser Met Ser Glu Ser Asp 
785                 790                 795                 800 


Leu Thr Thr Ser Gly Arg Tyr Arg Ala Arg Arg Asp Ser Leu Lys Lys 
                805                 810                 815     


Arg Pro Val Ser Asp Leu Leu Ser Gly Lys Lys Asn Ile Val Glu Gly 
            820                 825                 830         


Leu Pro Pro Leu Gly Gly Met Lys Lys Thr Arg Val Asp Ala Lys Lys 
        835                 840                 845             


Ile Gly Pro Leu Lys Leu Ala Ala Leu Asn Gly Leu Ser Leu Ser Arg 
    850                 855                 860                 


Val Pro Leu Pro Asp Glu Gly Lys Glu Val Ala Thr Arg Ala Thr Asn 
865                 870                 875                 880 


Asp Glu Arg Cys Lys Ile Leu Glu Gln Arg Leu Glu Gln Gly Met Val 
                885                 890                 895     


Phe Thr Glu Tyr Glu Arg Ile Leu Lys Lys Arg Leu Val Asp Gly Glu 
            900                 905                 910         


Cys Ser Thr Ala Arg Leu Pro Glu Asn Ala Glu Arg Asn Arg Phe Gln 
        915                 920                 925             


Asp Val Leu Pro Tyr Asp Asp Val Arg Val Glu Leu Val Pro Thr Lys 
    930                 935                 940                 


Glu Asn Asn Thr Gly Tyr Ile Asn Ala Ser His Ile Lys Val Ser Val 
945                 950                 955                 960 


Ser Gly Ile Glu Trp Asp Tyr Ile Ala Thr Gln Gly Pro Leu Gln Asn 
                965                 970                 975     


Thr Cys Gln Asp Phe Trp Gln Met Val Trp Glu Gln Gly Ile Ala Ile 
            980                 985                 990         


Ile Ala Met Val Thr Ala Glu Glu  Glu Gly Gly Arg Glu  Lys Ser Phe 
        995                 1000                 1005             


Arg Tyr  Trp Pro Arg Leu Gly  Ser Arg His Asn Thr  Val Thr Tyr 
    1010                 1015                 1020             


Gly Arg  Phe Lys Ile Thr Thr  Arg Phe Arg Thr Asp  Ser Gly Cys 
    1025                 1030                 1035             


Tyr Ala  Thr Thr Gly Leu Lys  Met Lys His Leu Leu  Thr Gly Gln 
    1040                 1045                 1050             


Glu Arg  Thr Val Trp His Leu  Gln Tyr Thr Asp Trp  Pro Glu His 
    1055                 1060                 1065             


Gly Cys  Pro Glu Asp Leu Lys  Gly Phe Leu Ser Tyr  Leu Glu Glu 
    1070                 1075                 1080             


Ile Gln  Ser Val Arg Arg His  Thr Asn Ser Thr Ser  Asp Pro Gln 
    1085                 1090                 1095             


Ser Pro  Asn Pro Pro Leu Leu  Val His Cys Ser Ala  Gly Val Gly 
    1100                 1105                 1110             


Arg Thr  Gly Val Val Ile Leu  Ser Glu Ile Met Ile  Ala Cys Leu 
    1115                 1120                 1125             


Glu His  Asn Glu Val Leu Asp  Ile Pro Arg Val Leu  Asp Met Leu 
    1130                 1135                 1140             


Arg Gln  Gln Arg Met Met Leu  Val Gln Thr Leu Cys  Gln Tyr Thr 
    1145                 1150                 1155             


Phe Val  Tyr Arg Val Leu Ile  Gln Phe Leu Lys Ser  Ser Arg Leu 
    1160                 1165                 1170             


Ile 
    


<210> 5519
<211> 744
<212> PRT
<213> Homo sapiens

<400> 5519
Met Ala Ala Asp Lys Pro Ala Asp Gln Gly Ala Glu Lys His Glu Gly 
1               5                   10                  15      


Thr Gly Gln Ser Ser Gly Ile Thr Asp Gln Glu Lys Glu Leu Ser Thr 
            20                  25                  30          


Asn Ala Phe Gln Ala Phe Thr Ser Gly Asn Tyr Asp Ala Cys Leu Gln 
        35                  40                  45              


His Leu Ala Cys Leu Gln Asp Ile Asn Lys Asp Asp Tyr Lys Ile Ile 
    50                  55                  60                  


Leu Asn Thr Ala Val Ala Glu Phe Phe Lys Ser Asn Gln Thr Thr Thr 
65                  70                  75                  80  


Asp Asn Leu Arg Gln Thr Leu Asn Gln Leu Lys Asn Gln Val His Ser 
                85                  90                  95      


Ala Val Glu Glu Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu 
            100                 105                 110         


Tyr Tyr Asn Gln Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Thr Glu 
        115                 120                 125             


Ala Ile Ser Val Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu 
    130                 135                 140                 


Glu Lys Phe Ala Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile 
145                 150                 155                 160 


Leu Thr Tyr Gln Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu 
                165                 170                 175     


Lys Met Ile Ser Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Thr 
            180                 185                 190         


Gly Asn Asn Asn Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly 
        195                 200                 205             


Ala Leu Ile Glu Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg 
    210                 215                 220                 


Ala Tyr Ile Gln Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys 
225                 230                 235                 240 


Ser Val Met Asn Thr Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys 
                245                 250                 255     


Ser Asn Phe Glu Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu 
            260                 265                 270         


Leu Asn Ser Ser Asn Ile Ala Glu His Pro Gly Phe Met Lys Thr Gly 
        275                 280                 285             


Glu Cys Leu Arg Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe 
    290                 295                 300                 


Ala Met Ser Lys His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu 
305                 310                 315                 320 


Gln Glu Asn Asp Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Thr Asp 
                325                 330                 335     


Pro Gly Lys Lys Phe Ser Gly Arg Pro Met Cys Thr Leu Leu Thr Asn 
            340                 345                 350         


Lys Arg Tyr Glu Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile 
        355                 360                 365             


Gly Arg Pro Leu Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val 
    370                 375                 380                 


Tyr His Ala Asn Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile 
385                 390                 395                 400 


Ala Ala Asn Lys Gly Thr Ser Glu Gln Glu Thr Lys Gly Leu Pro Ser 
                405                 410                 415     


Lys Lys Gly Ile Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys 
            420                 425                 430         


Ile Val Leu Ala Ser Gln Ser Ile Gln Asn Thr Val Tyr Asn Asp Gly 
        435                 440                 445             


Gln Ser Ser Ala Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys 
    450                 455                 460                 


Leu Arg Asn Ala Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys 
465                 470                 475                 480 


Gln Glu Asn Gly Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Thr Glu 
                485                 490                 495     


Ser Ser Glu Ser Ser Glu Thr Cys Ser Ser Lys Ser His Asp Gly Asp 
            500                 505                 510         


Lys Phe Ile Pro Ala Pro Pro Ser Ser Pro Leu Arg Lys Gln Glu Leu 
        515                 520                 525             


Glu Asn Leu Lys Cys Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu 
    530                 535                 540                 


Ala Leu Gly Asp Asn Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu 
545                 550                 555                 560 


Gln Gln Pro Lys Leu Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr 
                565                 570                 575     


Ala Ala Glu Ala Leu Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Thr 
            580                 585                 590         


His Leu Asn Pro Glu Asn Val Thr Asp Val Ser Leu Gly Ile Ser Ser 
        595                 600                 605             


Asn Glu Gln Asp Gln Gly Ser Asp Lys Gly Glu Asn Glu Ala Met Glu 
    610                 615                 620                 


Ser Ser Gly Lys Arg Ala Pro Gln Cys Tyr Pro Ser Ser Val Asn Ser 
625                 630                 635                 640 


Ala Arg Thr Val Met Leu Phe Asn Leu Gly Ser Ala Tyr Cys Leu Arg 
                645                 650                 655     


Ser Glu Tyr Asp Lys Ala Arg Lys Cys Leu His Gln Ala Ala Ser Met 
            660                 665                 670         


Ile His Pro Lys Glu Val Pro Pro Glu Ala Ile Leu Leu Ala Val Tyr 
        675                 680                 685             


Leu Glu Leu Gln Asn Gly Asn Thr Gln Leu Ala Leu Gln Ile Ile Lys 
    690                 695                 700                 


Arg Asn Gln Leu Leu Pro Ala Val Lys Thr His Ser Glu Val Arg Lys 
705                 710                 715                 720 


Lys Pro Val Phe Gln Pro Val His Pro Ile Gln Pro Ile Gln Met Pro 
                725                 730                 735     


Ala Phe Thr Thr Val Gln Arg Lys 
            740                 


<210> 5520
<211> 120
<212> PRT
<213> Homo sapiens

<400> 5520
Met His Pro Pro Pro Pro Ala Ala Ala Met Asp Phe Ser Gln Asn Ser 
1               5                   10                  15      


Leu Phe Gly Tyr Met Glu Asp Leu Gln Glu Leu Thr Ile Ile Glu Arg 
            20                  25                  30          


Pro Val Arg Arg Ser Leu Lys Thr Pro Glu Glu Ile Glu Arg Leu Thr 
        35                  40                  45              


Val Asp Glu Asp Leu Ser Asp Ile Glu Arg Ala Val Tyr Leu Leu Ser 
    50                  55                  60                  


Ala Gly Gln Asp Val Gln Gly Thr Ser Val Ile Ala Asn Leu Pro Phe 
65                  70                  75                  80  


Leu Met Arg Gln Asn Pro Thr Glu Thr Leu Arg Arg Val Leu Pro Lys 
                85                  90                  95      


Val Arg Val His Glu Asp Ala His Leu Phe Ile Gln Arg Val Trp Ile 
            100                 105                 110         


Ser His Met Phe Val Gln Arg Val 
        115                 120 


<210> 5521
<211> 444
<212> PRT
<213> Homo sapiens

<400> 5521
Met Arg Glu Ile Val Leu Thr Gln Ile Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Ala Ile Asp Ser 
            20                  25                  30          


Ala Gly Thr Tyr His Gly Asp Ser His Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Gly Gly Arg Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Val Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Cys Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Met Glu Ser Val Met Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Leu Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Ile Asn Thr Phe Ser Ile Leu Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Ile Glu Asn Ala Asp Glu Thr Phe Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Ser Lys Thr Leu Lys Leu Pro Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Ala Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Ala Ala Ala Ile Phe Arg Gly Arg 
305                 310                 315                 320 


Met Pro Met Arg Glu Val Asp Glu Gln Met Phe Asn Ile Gln Asp Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Ala Asp Trp Leu Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Asn Thr Ala Ile Gln Glu Leu Phe Lys Arg Val Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Glu Asp Glu Glu Tyr Ala Glu Glu Glu Val Ala 
        435                 440                 


<210> 5522
<211> 304
<212> PRT
<213> Homo sapiens

<400> 5522
Met Ala Lys Ile Glu Lys Asn Ala Pro Thr Met Glu Lys Lys Pro Glu 
1               5                   10                  15      


Leu Phe Asn Ile Met Glu Val Asp Gly Val Pro Thr Leu Ile Leu Ser 
            20                  25                  30          


Lys Glu Trp Trp Glu Lys Val Cys Asn Phe Gln Ala Lys Pro Asp Asp 
        35                  40                  45              


Leu Ile Leu Ala Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met His Glu 
    50                  55                  60                  


Ile Leu Asp Met Ile Leu Asn Asp Gly Asp Val Glu Lys Cys Lys Arg 
65                  70                  75                  80  


Ala Gln Thr Leu Asp Arg His Ala Phe Leu Glu Leu Lys Phe Pro His 
                85                  90                  95      


Lys Glu Lys Pro Asp Leu Glu Phe Val Leu Glu Met Ser Ser Pro Gln 
            100                 105                 110         


Leu Ile Lys Thr His Leu Pro Ser His Leu Ile Pro Pro Ser Ile Trp 
        115                 120                 125             


Lys Glu Asn Cys Lys Ile Val Tyr Val Ala Arg Asn Pro Lys Asp Cys 
    130                 135                 140                 


Leu Val Ser Tyr Tyr His Phe His Arg Met Ala Ser Phe Met Pro Asp 
145                 150                 155                 160 


Pro Gln Asn Leu Glu Glu Phe Tyr Glu Lys Phe Met Ser Gly Lys Val 
                165                 170                 175     


Val Gly Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp Ala Ala Lys 
            180                 185                 190         


Asp Met His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Ile Lys Lys Asp 
        195                 200                 205             


Pro Lys Arg Glu Ile Glu Lys Ile Leu Lys Phe Leu Glu Lys Asp Ile 
    210                 215                 220                 


Ser Glu Glu Ile Leu Asn Lys Ile Ile Tyr His Thr Ser Phe Asp Val 
225                 230                 235                 240 


Met Lys Gln Asn Pro Met Thr Asn Tyr Thr Thr Leu Pro Thr Ser Ile 
                245                 250                 255     


Met Asp His Ser Ile Ser Pro Phe Met Arg Lys Gly Met Pro Gly Asp 
            260                 265                 270         


Trp Lys Asn Tyr Phe Thr Val Ala Gln Asn Glu Glu Phe Asp Lys Asp 
        275                 280                 285             


Tyr Gln Lys Lys Met Ala Gly Ser Thr Leu Thr Phe Arg Thr Glu Ile 
    290                 295                 300                 


<210> 5523
<211> 71
<212> PRT
<213> Homo sapiens

<400> 5523
Met Cys Gly Ser Tyr Tyr Gly Asn Tyr Tyr Gly Thr Pro Gly Tyr Gly 
1               5                   10                  15      


Phe Cys Gly Tyr Gly Gly Leu Gly Tyr Gly Tyr Gly Gly Leu Gly Cys 
            20                  25                  30          


Gly Tyr Gly Ser Cys Cys Gly Cys Gly Phe Arg Arg Leu Gly Cys Gly 
        35                  40                  45              


Tyr Gly Tyr Gly Ser Arg Ser Leu Cys Gly Tyr Gly Tyr Gly Cys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Tyr Tyr Tyr 
65                  70      


<210> 5524
<211> 697
<212> PRT
<213> Homo sapiens

<400> 5524
Met Asp Lys Lys Ser Thr Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu 
1               5                   10                  15      


Gln Ala Lys Glu Leu Ser Ala Val His Ser Ser His His Glu Ile Gly 
            20                  25                  30          


Val Asn Asp Ser Asn Leu Phe Ser Leu Glu Met Arg Glu Pro Leu Glu 
        35                  40                  45              


Ser Ser Asn Thr Lys Ser Phe His Ser Ala Val Glu Ile Lys Asn Arg 
    50                  55                  60                  


Ser Gln His Glu Leu Pro Cys Phe Gln His His Gly Ile Asp Thr Pro 
65                  70                  75                  80  


Thr Ser Leu Gln Lys Arg Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg 
                85                  90                  95      


Leu Glu Glu Thr Ala Ser Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp 
            100                 105                 110         


Asp Asp Leu Pro Phe Ser Glu Ser Leu Asn Lys Phe Leu Ala Val Leu 
        115                 120                 125             


Glu Ser Glu Ile Ala Val Thr Gln Ala Asp Val Ser Ser Arg Lys His 
    130                 135                 140                 


His Val Asp Asn Asp Ile Asp Lys Phe His Ala Asp His Ser Arg Leu 
145                 150                 155                 160 


Ser Val Thr Pro Gln Arg Thr Thr Gly Ala Leu His Thr Pro Pro Ile 
                165                 170                 175     


Ala Leu Arg Ser Ser Gln Val Ile Val Lys Ala Asn Cys Ser Lys Asp 
            180                 185                 190         


Asp Phe Leu Phe Asn Cys Lys Gly Asn Leu Ser Pro Ser Val Glu Lys 
        195                 200                 205             


Glu Ser Gln Pro Asp Asn Lys Val Glu Ala Val Ser Val Asn His Asn 
    210                 215                 220                 


Gly Arg Asp Met Ser Glu Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala 
225                 230                 235                 240 


Leu Ser Ser Ser Ser Lys Asp Leu Glu Thr Ile Val Thr Leu Lys Lys 
                245                 250                 255     


Thr Ile Arg Ile Ser Pro His Arg Glu Ser Asp His Ser Ser Leu Asn 
            260                 265                 270         


Asn Lys Tyr Leu Asn Gly Cys Gly Glu Ile Ser Val Ser Glu Met Asn 
        275                 280                 285             


Glu Lys Leu Thr Thr Leu Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp 
    290                 295                 300                 


Leu Cys Lys Leu Glu Asn Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln 
305                 310                 315                 320 


Asp Asp Ser Phe Thr Ile Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr 
                325                 330                 335     


Leu Cys Asn Ser Pro Asn Arg Ser Thr Asn Thr Leu Lys Glu Met Pro 
            340                 345                 350         


Trp Gly His Ile Asn Asn Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr 
        355                 360                 365             


Glu Gly Ser Tyr Asp Ala Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys 
    370                 375                 380                 


Glu Met Asp Ile Ala Thr Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu 
385                 390                 395                 400 


Leu Lys Trp Gly Thr Ser Leu Ala Glu Ser His Pro Ser Glu Ser Asp 
                405                 410                 415     


Phe Ser Leu Arg Ser Leu Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys 
            420                 425                 430         


Leu Ser Leu Gln Ser Leu Ser Asp Ser Arg His Ser Arg Thr Cys Ser 
        435                 440                 445             


Pro Thr Pro His Phe Gln Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser 
    450                 455                 460                 


Gln Asp Phe Val Pro Cys Ser Gln Ser Thr Pro Ile Ser Gly Phe His 
465                 470                 475                 480 


Gln Thr Arg Ile His Gly Ile Asn Arg Ala Phe Lys Lys Pro Val Phe 
                485                 490                 495     


Tyr Ser Asp Leu Asp Gly Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu 
            500                 505                 510         


Asn Asp Lys Gln Gln Ala Ser Pro Ser Cys Pro Lys Asn Ile Lys Thr 
        515                 520                 525             


Pro Ser Gln Lys Ile Arg Ser Pro Ile Val Ser Gly Val Ser Gln Pro 
    530                 535                 540                 


Asp Val Phe Asn His Tyr Pro Phe Ala Glu Cys His Glu Thr Asp Ser 
545                 550                 555                 560 


Asp Glu Trp Val Pro Pro Thr Thr Gln Lys Ile Phe Pro Ser Asp Met 
                565                 570                 575     


Leu Gly Phe Gln Gly Ile Gly Leu Gly Lys Cys Leu Ala Ala Tyr His 
            580                 585                 590         


Phe Pro Asp Gln Gln Glu Leu Pro Arg Lys Lys Leu Lys His Ile Arg 
        595                 600                 605             


Gln Gly Thr Asn Lys Gly Leu Ile Lys Lys Lys Leu Lys Asn Met Leu 
    610                 615                 620                 


Ala Ala Val Val Thr Lys Lys Lys Thr His Lys Tyr Asn Cys Lys Ser 
625                 630                 635                 640 


Ser Gly Trp Ile Ser Lys Cys Pro Asp Ile Gln Val Leu Ala Ala Pro 
                645                 650                 655     


Gln Leu His Pro Ile Leu Gly Pro Asp Ser Cys Ser Glu Val Lys Cys 
            660                 665                 670         


Cys Leu Pro Phe Ser Glu Lys Gly Pro Pro Ser Val Cys Glu Thr Arg 
        675                 680                 685             


Ser Ala Trp Ser Pro Glu Leu Phe Ser 
    690                 695         


<210> 5525
<211> 101
<212> PRT
<213> Homo sapiens

<400> 5525
Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Gly Arg Asp Gly Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Ile His Tyr Leu Ala Thr Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Ala Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210> 5526
<211> 225
<212> PRT
<213> Homo sapiens

<400> 5526
Met Ala Val Arg Ser Leu Trp Ala Gly Arg Leu Arg Val Gln Arg Leu 
1               5                   10                  15      


Leu Ala Trp Ser Ala Ala Trp Glu Ser Lys Gly Trp Pro Leu Pro Phe 
            20                  25                  30          


Ser Thr Ala Thr Gln Arg Thr Ala Gly Glu Asp Cys Arg Ser Glu Asp 
        35                  40                  45              


Pro Pro Asp Glu Leu Gly Pro Pro Leu Ala Glu Arg Ala Leu Arg Val 
    50                  55                  60                  


Lys Ala Val Lys Leu Glu Lys Glu Val Gln Asp Leu Thr Val Arg Tyr 
65                  70                  75                  80  


Gln Arg Ala Ile Ala Asp Cys Glu Asn Ile Arg Arg Arg Thr Gln Arg 
                85                  90                  95      


Cys Val Glu Asp Ala Lys Ile Phe Gly Ile Gln Ser Phe Cys Lys Asp 
            100                 105                 110         


Leu Val Glu Val Ala Asp Ile Leu Glu Lys Thr Thr Glu Cys Ile Ser 
        115                 120                 125             


Glu Glu Ser Glu Pro Glu Asp Gln Lys Leu Thr Leu Glu Lys Val Phe 
    130                 135                 140                 


Arg Gly Leu Leu Leu Leu Glu Ala Lys Leu Lys Ser Val Phe Ala Lys 
145                 150                 155                 160 


His Gly Leu Glu Lys Leu Thr Pro Ile Gly Asp Lys Tyr Asp Pro His 
                165                 170                 175     


Glu His Glu Leu Ile Cys His Val Pro Ala Gly Val Gly Val Gln Pro 
            180                 185                 190         


Gly Thr Val Ala Leu Val Arg Gln Asp Gly Tyr Lys Leu His Gly Arg 
        195                 200                 205             


Thr Ile Arg Leu Ala Arg Val Glu Val Ala Val Glu Ser Gln Arg Arg 
    210                 215                 220                 


Leu 
225 


<210> 5527
<211> 400
<212> PRT
<213> Homo sapiens

<400> 5527
Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Thr Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Thr Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu Leu Ser Glu Arg Glu Gln 
                245                 250                 255     


Phe Arg Gln Glu Met Ile Ala Thr Gln Lys Leu Leu Glu Glu Leu Leu 
            260                 265                 270         


Val Ser Leu Gln Trp Gly Arg Glu Gln Thr Tyr Ser Pro Ser Val Gln 
        275                 280                 285             


Pro His Ser Thr Ala Glu Leu Ala Leu Thr Asn His Lys Leu Ala Lys 
    290                 295                 300                 


Ala Val Asn Ser His Leu Leu Gly Asn Val Gly Ile Asn Asn Gln Lys 
305                 310                 315                 320 


Lys Ile Pro Ser Thr Val Glu Phe Cys Ser Thr Pro Ala Glu Lys Met 
                325                 330                 335     


Ala Glu Thr Val Leu Arg Ile Leu Asp Pro Val Thr Cys Lys Glu Ser 
            340                 345                 350         


Ser Pro Asp Asn Pro Phe Phe Glu Ser Ser Pro Thr Thr Leu Leu Ala 
        355                 360                 365             


Thr Lys Lys Asn Ile Gly Arg Phe His Pro Tyr Thr Arg Tyr Glu Asn 
    370                 375                 380                 


Ile Thr Phe Asn Cys Cys Asn His Cys Arg Gly Glu Leu Ile Ala Leu 
385                 390                 395                 400 


<210> 5528
<211> 244
<212> PRT
<213> Homo sapiens

<400> 5528
Met Asp Pro Gly Ala Ala Leu Gln Arg Arg Ala Gly Gly Gly Gly Gly 
1               5                   10                  15      


Leu Gly Ala Gly Ser Pro Ala Leu Ser Gly Gly Gln Gly Arg Arg Arg 
            20                  25                  30          


Lys Gln Pro Pro Arg Pro Ala Asp Phe Lys Leu Gln Val Ile Ile Ile 
        35                  40                  45              


Gly Ser Arg Gly Val Gly Lys Thr Ser Leu Met Glu Arg Phe Thr Asp 
    50                  55                  60                  


Asp Thr Phe Cys Glu Ala Cys Lys Ser Thr Val Gly Val Asp Phe Lys 
65                  70                  75                  80  


Ile Lys Thr Val Glu Leu Arg Gly Lys Lys Ile Arg Leu Gln Ile Trp 
                85                  90                  95      


Asp Thr Ala Gly Gln Glu Arg Phe Asn Ser Ile Thr Ser Ala Tyr Tyr 
            100                 105                 110         


Arg Ser Ala Lys Gly Ile Ile Leu Val Tyr Asp Ile Thr Lys Lys Glu 
        115                 120                 125             


Thr Phe Asp Asp Leu Pro Lys Trp Met Lys Met Ile Asp Lys Tyr Ala 
    130                 135                 140                 


Ser Glu Asp Ala Glu Leu Leu Leu Val Gly Asn Lys Leu Asp Cys Glu 
145                 150                 155                 160 


Thr Asp Arg Glu Ile Thr Arg Gln Gln Gly Glu Lys Phe Ala Gln Gln 
                165                 170                 175     


Ile Thr Gly Met Arg Phe Cys Glu Ala Ser Ala Lys Asp Asn Phe Asn 
            180                 185                 190         


Val Asp Glu Ile Phe Leu Lys Leu Val Asp Asp Ile Leu Lys Lys Met 
        195                 200                 205             


Pro Leu Asp Ile Leu Arg Asn Glu Leu Ser Asn Ser Ile Leu Ser Leu 
    210                 215                 220                 


Gln Pro Glu Pro Glu Ile Pro Pro Glu Leu Pro Pro Pro Arg Pro His 
225                 230                 235                 240 


Val Arg Cys Cys 
                


<210> 5529
<211> 385
<212> PRT
<213> Homo sapiens

<400> 5529
Met Ala Leu Pro His Asp Ser Asn Glu Thr Ser Tyr Leu Leu Pro Pro 
1               5                   10                  15      


Asn Asn Glu Asp Trp Gly Arg Gln Thr Ile Pro Asp Phe Val Tyr Gly 
            20                  25                  30          


Gln Lys Asp Leu Met Ala Glu Gly Ile Gln Trp Pro Arg Asn Ala Pro 
        35                  40                  45              


Gly Ile Pro Asp Ala Leu Pro Gln Ser Pro Phe Asp Ala Ala Leu Cys 
    50                  55                  60                  


Ser Ala Trp Lys Gln Arg Val Glu Leu Gly Leu Phe Arg Tyr Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Gln Thr Gln Ile Leu Pro Gly Ala Val Gly Phe Val Ala 
                85                  90                  95      


Gln Leu Asn Val Glu Arg Gly Val Gln Arg Arg Pro Pro Gln Thr Ile 
            100                 105                 110         


Lys Ser Val Arg Gln Ala Phe Asp Pro Val Gln Phe Asn Phe Asn Lys 
        115                 120                 125             


Ile Arg Pro Gly Glu Val Leu Phe Arg Leu His Arg Glu Pro Asp Leu 
    130                 135                 140                 


Pro Gly Thr Leu Leu Gln Glu Asp Ile Leu Val Val Ile Asn Val Ser 
145                 150                 155                 160 


Pro Leu Glu Trp Gly His Val Leu Leu Val Pro Glu Pro Ala Arg Gln 
                165                 170                 175     


Leu Pro Gln Arg Leu Leu Pro Gly Ala Leu Arg Ala Gly Ile Glu Ala 
            180                 185                 190         


Val Leu Leu Ser Leu His Pro Gly Phe Arg Val Gly Phe Asn Ser Leu 
        195                 200                 205             


Gly Gly Leu Ala Ser Val Asn His Leu His Leu His Gly Tyr Tyr Leu 
    210                 215                 220                 


Ala His Arg Leu Pro Val Glu Gln Ala Pro Ser Glu Pro Leu Asp Pro 
225                 230                 235                 240 


Gly Gly His Leu His Leu Leu Gln Asp Leu Pro Ala Pro Gly Phe Leu 
                245                 250                 255     


Phe Tyr Thr Arg Gly Pro Gly Pro Asp Leu Glu Ser Leu Ile Ser Arg 
            260                 265                 270         


Val Cys Arg Ala Thr Asp Tyr Leu Thr Asp His Glu Ile Ala His Asn 
        275                 280                 285             


Leu Phe Val Thr Arg Gly Ala Pro Pro Gly Lys Thr Ser Pro Ser Ser 
    290                 295                 300                 


Ala Leu Thr Gly Val Arg Val Ile Leu Trp Ala Arg Lys Ser Ser Phe 
305                 310                 315                 320 


Gly Ile Lys Asp Gly Glu Ala Phe Asn Val Ala Leu Cys Glu Leu Ala 
                325                 330                 335     


Gly His Leu Pro Val Lys Thr Ser Gln Asp Phe Ser Ser Leu Thr Glu 
            340                 345                 350         


Ala Ala Ala Val Ala Leu Ile Gln Asp Cys Arg Leu Pro Pro Ser Gln 
        355                 360                 365             


Ala Glu Asp Val Gln Ala Ala Leu Val Ala Leu Met Ser Gln Glu Glu 
    370                 375                 380                 


Gln 
385 


<210> 5530
<211> 63
<212> PRT
<213> Homo sapiens

<400> 5530
Met Leu Cys Asp Asn Phe Pro Gly Ala Val Phe Pro Gly Cys Tyr Trp 
1               5                   10                  15      


Gly Ser Tyr Gly Tyr Pro Leu Gly Tyr Ser Val Gly Cys Gly Tyr Gly 
            20                  25                  30          


Ser Thr Tyr Ser Pro Val Gly Tyr Gly Phe Gly Tyr Gly Tyr Asn Gly 
        35                  40                  45              


Cys Gly Ala Phe Gly Tyr Arg Arg Tyr Ser Pro Phe Ala Leu Tyr 
    50                  55                  60              


<210> 5531
<211> 360
<212> PRT
<213> Homo sapiens

<400> 5531
Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg 
1               5                   10                  15      


Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu 
            20                  25                  30          


Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys 
        35                  40                  45              


Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr 
    50                  55                  60                  


Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu 
65                  70                  75                  80  


Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu 
                85                  90                  95      


Ala Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser 
            100                 105                 110         


Glu Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr 
        115                 120                 125             


Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val 
    130                 135                 140                 


Asn Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile 
145                 150                 155                 160 


Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro 
                165                 170                 175     


Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu 
            180                 185                 190         


Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly 
        195                 200                 205             


Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro 
    210                 215                 220                 


Asp Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser 
225                 230                 235                 240 


Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp Phe 
                245                 250                 255     


Asn Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His Pro 
            260                 265                 270         


Pro Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu Ser Met Thr Leu Met 
        275                 280                 285             


Leu Ile Arg Ile Ser Leu Leu His Arg Leu Leu Val Leu Asp Pro Ser 
    290                 295                 300                 


Gln Lys Pro Leu Gln Ser Phe Leu Pro Asp Leu Gln Ile Thr Met Thr 
305                 310                 315                 320 


Thr Leu Ser Tyr Gln Ser Cys His Leu Cys Gln Thr His Tyr Gln Leu 
                325                 330                 335     


His Leu Leu Val Pro Ala Pro Gln His Leu Lys Thr Leu Thr Leu Met 
            340                 345                 350         


Ile Phe Pro Gly Gly Leu Lys Ser 
        355                 360 


<210> 5532
<211> 175
<212> PRT
<213> Homo sapiens

<400> 5532
Met Pro Lys Arg Ser Cys Pro Phe Ala Asp Val Ala Pro Leu Gln Leu 
1               5                   10                  15      


Lys Val Arg Val Ser Gln Arg Glu Leu Ser Arg Gly Val Cys Ala Glu 
            20                  25                  30          


Arg Tyr Ser Gln Glu Val Phe Glu Lys Thr Lys Arg Leu Leu Phe Leu 
        35                  40                  45              


Gly Ala Gln Ala Tyr Leu Asp His Val Trp Asp Glu Gly Cys Ala Val 
    50                  55                  60                  


Val His Leu Pro Glu Ser Pro Lys Pro Gly Pro Thr Gly Ala Pro Arg 
65                  70                  75                  80  


Ala Ala Arg Gly Gln Met Leu Ile Gly Pro Asp Gly Arg Leu Ile Arg 
                85                  90                  95      


Ser Leu Gly Gln Ala Ser Glu Ala Asp Pro Ser Gly Val Ala Ser Ile 
            100                 105                 110         


Ala Cys Ser Ser Cys Val Arg Ala Val Asp Gly Lys Ala Val Cys Gly 
        115                 120                 125             


Gln Cys Glu Arg Ala Leu Cys Gly Gln Cys Val Arg Thr Cys Trp Gly 
    130                 135                 140                 


Cys Gly Ser Val Ala Cys Thr Leu Cys Gly Leu Val Asp Cys Ser Asp 
145                 150                 155                 160 


Met Tyr Glu Lys Val Leu Cys Thr Ser Cys Ala Met Phe Glu Thr 
                165                 170                 175 


<210> 5533
<211> 121
<212> PRT
<213> Homo sapiens

<400> 5533
Met Glu Ala Glu Val Asp Lys Leu Glu Leu Met Phe Gln Lys Ala Glu 
1               5                   10                  15      


Ser Asp Leu Asp Tyr Ile Gln Tyr Arg Leu Glu Tyr Glu Ile Lys Thr 
            20                  25                  30          


Asn His Pro Asp Ser Ala Ser Glu Lys Asn Pro Val Thr Leu Leu Lys 
        35                  40                  45              


Glu Leu Ser Val Ile Lys Ser Arg Tyr Gln Thr Leu Tyr Ala Arg Phe 
    50                  55                  60                  


Lys Pro Val Ala Val Glu Gln Lys Glu Ser Lys Ser Arg Ile Cys Ala 
65                  70                  75                  80  


Thr Val Lys Lys Thr Met Asn Met Ile Gln Lys Leu Gln Lys Gln Thr 
                85                  90                  95      


Asp Leu Glu Leu Ser Pro Leu Thr Lys Glu Glu Lys Thr Ala Ala Glu 
            100                 105                 110         


Gln Phe Lys Phe His Met Pro Asp Leu 
        115                 120     


<210> 5534
<211> 655
<212> PRT
<213> Homo sapiens

<400> 5534
Met Val Thr Thr Leu Gly Pro Lys Met Ala Ala Glu Trp Gly Gly Gly 
1               5                   10                  15      


Val Gly Tyr Ser Gly Ser Gly Pro Gly Arg Ser Arg Trp Arg Trp Ser 
            20                  25                  30          


Gly Ser Val Trp Val Arg Ser Val Leu Leu Leu Leu Gly Gly Leu Arg 
        35                  40                  45              


Ala Ser Ala Thr Ser Thr Pro Val Ser Leu Gly Ser Ser Pro Pro Cys 
    50                  55                  60                  


Arg His His Val Pro Ser Asp Thr Glu Val Ile Asn Lys Val His Leu 
65                  70                  75                  80  


Lys Ala Asn His Val Val Lys Arg Asp Val Asp Glu His Leu Arg Ile 
                85                  90                  95      


Lys Thr Val Tyr Asp Lys Ser Val Glu Glu Leu Leu Pro Glu Lys Lys 
            100                 105                 110         


Asn Leu Val Lys Asn Lys Leu Phe Pro Gln Ala Ile Ser Tyr Leu Glu 
        115                 120                 125             


Lys Thr Phe Gln Val Arg Arg Pro Ala Gly Thr Ile Leu Leu Ser Arg 
    130                 135                 140                 


Gln Cys Ala Thr Asn Gln Tyr Leu Arg Lys Glu Asn Asp Pro His Arg 
145                 150                 155                 160 


Tyr Cys Thr Gly Glu Cys Ala Ala His Thr Lys Cys Gly Pro Val Ile 
                165                 170                 175     


Val Pro Glu Glu His Leu Gln Gln Cys Arg Val Tyr Arg Gly Gly Lys 
            180                 185                 190         


Trp Pro His Gly Ala Val Gly Val Pro Asp Gln Glu Gly Ile Ser Asp 
        195                 200                 205             


Ala Asp Phe Val Leu Tyr Val Gly Ala Leu Ala Thr Glu Arg Cys Ser 
    210                 215                 220                 


His Glu Asn Ile Ile Ser Tyr Ala Ala Tyr Cys Gln Gln Glu Ala Asn 
225                 230                 235                 240 


Met Asp Arg Pro Ile Ala Gly Tyr Ala Asn Leu Cys Pro Asn Met Ile 
                245                 250                 255     


Ser Thr Gln Pro Gln Glu Phe Val Gly Met Leu Ser Thr Val Lys His 
            260                 265                 270         


Glu Val Ile His Ala Leu Gly Phe Ser Ala Gly Leu Phe Ala Phe Tyr 
        275                 280                 285             


His Asp Lys Asp Gly Asn Pro Leu Thr Ser Arg Phe Ala Asp Gly Leu 
    290                 295                 300                 


Pro Pro Phe Asn Tyr Ser Leu Gly Leu Tyr Gln Trp Ser Asp Lys Val 
305                 310                 315                 320 


Val Arg Lys Val Glu Arg Leu Trp Asp Val Arg Asp Asn Lys Ile Val 
                325                 330                 335     


Arg His Thr Val Tyr Leu Leu Val Thr Pro Arg Val Val Glu Glu Ala 
            340                 345                 350         


Arg Lys His Phe Asp Cys Pro Val Leu Glu Gly Met Glu Leu Glu Asn 
        355                 360                 365             


Gln Gly Gly Val Gly Thr Glu Leu Asn His Trp Glu Lys Arg Leu Leu 
    370                 375                 380                 


Glu Asn Glu Ala Met Thr Gly Ser His Thr Gln Asn Arg Val Leu Ser 
385                 390                 395                 400 


Arg Ile Thr Leu Ala Leu Met Glu Asp Thr Gly Arg Gln Met Leu Ser 
                405                 410                 415     


Pro Tyr Cys Asp Thr Leu Arg Ser Asn Pro Leu Gln Leu Thr Cys Arg 
            420                 425                 430         


Gln Asp Gln Arg Ala Val Ala Val Cys Asn Leu Gln Lys Phe Pro Lys 
        435                 440                 445             


Pro Leu Pro Gln Glu Tyr Gln Tyr Phe Asp Glu Leu Ser Gly Ile Pro 
    450                 455                 460                 


Ala Glu Asp Leu Pro Tyr Tyr Gly Gly Ser Val Glu Ile Ala Asp Tyr 
465                 470                 475                 480 


Cys Pro Phe Ser Gln Glu Phe Ser Trp His Leu Ser Gly Glu Tyr Gln 
                485                 490                 495     


Arg Ser Ser Asp Cys Arg Ile Leu Glu Asn Gln Pro Glu Ile Phe Lys 
            500                 505                 510         


Asn Tyr Gly Ala Glu Lys Tyr Gly Pro His Ser Val Cys Leu Ile Gln 
        515                 520                 525             


Lys Ser Ala Phe Val Met Glu Lys Cys Glu Arg Lys Leu Ser Tyr Pro 
    530                 535                 540                 


Asp Trp Gly Ser Gly Cys Tyr Gln Val Ser Cys Ser Pro Gln Gly Leu 
545                 550                 555                 560 


Lys Val Trp Val Gln Asp Thr Ser Tyr Leu Cys Ser Arg Ala Gly Gln 
                565                 570                 575     


Val Leu Pro Val Ser Ile Gln Met Asn Gly Trp Ile His Asp Gly Asn 
            580                 585                 590         


Leu Leu Cys Pro Ser Cys Trp Asp Phe Cys Glu Leu Cys Pro Pro Glu 
        595                 600                 605             


Thr Asp Pro Pro Ala Thr Asn Leu Thr Arg Ala Leu Pro Leu Asp Leu 
    610                 615                 620                 


Cys Ser Cys Ser Ser Ser Leu Val Val Thr Leu Trp Leu Leu Leu Gly 
625                 630                 635                 640 


Asn Leu Phe Pro Leu Leu Ala Gly Phe Leu Leu Cys Ile Trp His 
                645                 650                 655 


<210> 5535
<211> 135
<212> PRT
<213> Homo sapiens

<400> 5535
Met Gly Arg Val Arg Thr Lys Thr Val Lys Lys Ala Ala Arg Val Ile 
1               5                   10                  15      


Ile Glu Lys Tyr Tyr Thr Arg Leu Gly Asn Asp Phe His Thr Asn Lys 
            20                  25                  30          


Arg Val Cys Glu Glu Ile Ala Ile Ile Pro Ser Lys Lys Leu Arg Asn 
        35                  40                  45              


Lys Ile Ala Gly Tyr Val Thr His Leu Met Lys Arg Ile Gln Arg Gly 
    50                  55                  60                  


Pro Val Arg Gly Ile Ser Ile Lys Leu Gln Glu Glu Glu Arg Glu Arg 
65                  70                  75                  80  


Arg Asp Asn Tyr Val Pro Glu Val Ser Ala Leu Asp Gln Glu Ile Ile 
                85                  90                  95      


Glu Val Asp Pro Asp Thr Lys Glu Met Leu Lys Leu Leu Asp Phe Gly 
            100                 105                 110         


Ser Leu Ser Asn Leu Gln Val Thr Gln Pro Thr Val Gly Met Asn Phe 
        115                 120                 125             


Lys Thr Pro Arg Gly Pro Val 
    130                 135 


<210> 5536
<211> 372
<212> PRT
<213> Homo sapiens

<400> 5536
Met Asn His Cys Gln Leu Pro Val Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Ile Lys Ala Gly Val Ala Gly Cys Arg Glu Pro Gln Phe Ile Tyr Pro 
            20                  25                  30          


Asn Ile Ile Gly Arg Ala Lys Gly Gln Ser Arg Ala Ala Gln Gly Gly 
        35                  40                  45              


Leu Glu Leu Cys Val Gly Asp Gln Ala Gln Asp Trp Arg Ser Ser Leu 
    50                  55                  60                  


Phe Ile Ser Tyr Pro Val Glu Arg Gly Leu Ile Thr Ser Trp Glu Asp 
65                  70                  75                  80  


Met Glu Ile Met Trp Lys His Ile Tyr Asp Tyr Asn Leu Lys Leu Lys 
                85                  90                  95      


Pro Cys Asp Gly Pro Val Leu Ile Thr Glu Pro Ala Leu Asn Pro Leu 
            100                 105                 110         


Ala Asn Arg Gln Gln Ile Thr Glu Met Phe Phe Glu His Leu Gly Val 
        115                 120                 125             


Pro Ala Phe Tyr Met Ser Ile Gln Ala Val Leu Ala Leu Phe Ala Ala 
    130                 135                 140                 


Gly Phe Thr Thr Gly Leu Val Leu Asn Ser Gly Ala Gly Val Thr Gln 
145                 150                 155                 160 


Ser Val Pro Ile Phe Glu Gly Tyr Cys Leu Pro His Gly Val Gln Gln 
                165                 170                 175     


Leu Asp Leu Ala Gly Leu Asp Leu Thr Asn Tyr Leu Met Val Leu Met 
            180                 185                 190         


Lys Asn His Gly Ile Met Leu Leu Ser Ala Ser Asp Arg Lys Ile Val 
        195                 200                 205             


Glu Asp Ile Lys Glu Ser Phe Cys Tyr Val Ala Met Asn Tyr Glu Glu 
    210                 215                 220                 


Glu Met Ala Lys Lys Pro Asp Cys Leu Glu Lys Val Tyr Gln Leu Pro 
225                 230                 235                 240 


Asp Gly Lys Val Ile Gln Leu His Asp Gln Leu Phe Ser Cys Pro Glu 
                245                 250                 255     


Ala Leu Phe Ser Pro Cys His Met Asn Leu Glu Ala Pro Gly Ile Asp 
            260                 265                 270         


Lys Ile Cys Phe Ser Ser Ile Met Lys Cys Asp Thr Gly Leu Arg Asn 
        275                 280                 285             


Ser Phe Phe Ser Asn Ile Ile Leu Ala Gly Gly Ser Thr Ser Phe Pro 
    290                 295                 300                 


Gly Leu Asp Lys Arg Leu Val Lys Asp Ile Ala Lys Val Ala Pro Ala 
305                 310                 315                 320 


Asn Thr Ala Val Gln Val Ile Ala Pro Pro Glu Arg Lys Ile Ser Val 
                325                 330                 335     


Trp Met Gly Gly Ser Ile Leu Ala Ser Leu Ser Ala Phe Gln Asp Met 
            340                 345                 350         


Trp Ile Thr Ala Ala Glu Phe Lys Glu Val Gly Pro Asn Ile Val His 
        355                 360                 365             


Gln Arg Cys Phe 
    370         


<210> 5537
<211> 1023
<212> PRT
<213> Homo sapiens

<400> 5537
Met Asp Ala Asn Ser Lys Asp Lys Pro Pro Glu Thr Lys Glu Ser Ala 
1               5                   10                  15      


Met Asn Asn Ala Gly Asn Ala Ser Phe Ile Leu Gly Thr Gly Lys Ile 
            20                  25                  30          


Val Thr Pro Gln Lys His Ala Glu Leu Pro Pro Asn Pro Cys Thr Pro 
        35                  40                  45              


Asp Thr Phe Lys Ser Pro Leu Asn Phe Ser Thr Val Thr Val Glu Gln 
    50                  55                  60                  


Leu Gly Ile Thr Pro Glu Ser Phe Val Arg Asn Ser Ala Gly Lys Ser 
65                  70                  75                  80  


Ser Ser Tyr Leu Lys Lys Cys Arg Arg Arg Ser Ala Val Gly Ala Arg 
                85                  90                  95      


Gly Ser Pro Glu Thr Asn His Leu Ile Arg Phe Ile Ala Arg Gln Gln 
            100                 105                 110         


Asn Ile Lys Asn Ala Arg Lys Ser Pro Leu Ala Gln Asp Ser Pro Ser 
        115                 120                 125             


Gln Gly Ser Pro Ala Leu Tyr Arg Asn Val Asn Thr Leu Arg Glu Arg 
    130                 135                 140                 


Ile Ser Ala Phe Gln Ser Ala Phe His Ser Ile Lys Glu Asn Glu Lys 
145                 150                 155                 160 


Met Thr Gly Cys Leu Glu Phe Ser Glu Ala Gly Lys Glu Ser Glu Met 
                165                 170                 175     


Thr Asp Leu Thr Arg Lys Glu Gly Leu Ser Ala Cys Gln Gln Ser Gly 
            180                 185                 190         


Phe Pro Ala Val Leu Ser Ser Lys Arg Arg Arg Ile Ser Tyr Gln Arg 
        195                 200                 205             


Asp Ser Asp Glu Asn Leu Thr Asp Ala Glu Gly Lys Val Ile Gly Leu 
    210                 215                 220                 


Gln Ile Phe Asn Ile Asp Thr Asp Arg Ala Cys Ala Val Glu Thr Ser 
225                 230                 235                 240 


Val Asp Leu Ser Glu Ile Ser Ser Lys Leu Gly Ser Thr Gln Ser Gly 
                245                 250                 255     


Phe Leu Val Glu Glu Ser Leu Pro Leu Ser Glu Leu Thr Glu Thr Ser 
            260                 265                 270         


Asn Ala Leu Lys Val Ala Asp Cys Val Val Gly Lys Gly Ser Ser Asp 
        275                 280                 285             


Ala Val Ser Pro Asp Thr Phe Thr Ala Glu Val Ser Ser Asp Ala Val 
    290                 295                 300                 


Pro Asp Val Arg Ser Pro Ala Thr Pro Ala Cys Arg Arg Asp Leu Pro 
305                 310                 315                 320 


Thr Pro Lys Thr Phe Val Leu Arg Ser Val Leu Lys Lys Pro Ser Val 
                325                 330                 335     


Lys Met Cys Leu Glu Ser Leu Gln Glu His Cys Asn Asn Leu Tyr Asp 
            340                 345                 350         


Asp Asp Gly Thr His Pro Ser Leu Ile Ser Asn Leu Pro Asn Cys Cys 
        355                 360                 365             


Lys Glu Lys Glu Ala Glu Asp Glu Glu Asn Phe Glu Ala Pro Ala Phe 
    370                 375                 380                 


Leu Asn Met Arg Lys Arg Lys Arg Val Thr Phe Gly Glu Asp Leu Ser 
385                 390                 395                 400 


Pro Glu Val Phe Asp Glu Ser Leu Pro Ala Asn Thr Pro Leu Arg Lys 
                405                 410                 415     


Gly Gly Thr Pro Val Cys Lys Lys Asp Phe Ser Gly Leu Ser Ser Leu 
            420                 425                 430         


Leu Leu Glu Gln Ser Pro Val Pro Glu Pro Leu Pro Gln Pro Asp Phe 
        435                 440                 445             


Asp Asp Lys Gly Glu Asn Leu Glu Asn Ile Glu Pro Leu Gln Val Ser 
    450                 455                 460                 


Phe Ala Val Leu Ser Ser Pro Asn Lys Ser Ser Ile Ser Glu Thr Leu 
465                 470                 475                 480 


Ser Gly Thr Asp Thr Phe Ser Ser Ser Asn Asn His Glu Lys Ile Ser 
                485                 490                 495     


Ser Pro Lys Val Gly Arg Ile Thr Arg Thr Ser Asn Arg Arg Asn Gln 
            500                 505                 510         


Leu Val Ser Val Val Glu Glu Ser Val Cys Asn Leu Leu Asn Thr Glu 
        515                 520                 525             


Val Gln Pro Cys Lys Glu Lys Lys Ile Asn Arg Arg Lys Ser Gln Glu 
    530                 535                 540                 


Thr Lys Cys Thr Lys Arg Ala Leu Pro Lys Lys Ser Gln Val Leu Lys 
545                 550                 555                 560 


Ser Cys Arg Lys Lys Lys Gly Lys Gly Lys Lys Ser Val Gln Lys Ser 
                565                 570                 575     


Leu Tyr Gly Glu Arg Asp Ile Ala Ser Lys Lys Pro Leu Leu Ser Pro 
            580                 585                 590         


Ile Pro Glu Leu Pro Glu Val Pro Glu Met Thr Pro Ser Ile Pro Ser 
        595                 600                 605             


Ile Arg Arg Leu Gly Ser Gly Tyr Phe Ser Ser Asn Gly Lys Leu Glu 
    610                 615                 620                 


Glu Val Lys Thr Pro Lys Asn Pro Val Lys Arg Lys Asp Leu Leu Arg 
625                 630                 635                 640 


His Asp Pro Asp Leu His Met His Gln Gly Tyr Asp Lys Tyr Asp Val 
                645                 650                 655     


Ser Glu Phe Cys Ser Tyr Ile Lys Ser Ser Ser Ser Leu Gly Asn Ala 
            660                 665                 670         


Thr Ser Asp Glu Asp Pro Asn Thr Asn Ile Met Asn Ile Asn Glu Asn 
        675                 680                 685             


Lys Asn Ile Pro Lys Ala Lys Asn Lys Ser Glu Ser Glu Asn Glu Pro 
    690                 695                 700                 


Lys Ala Gly Thr Asp Ser Pro Val Ser Cys Ala Ser Val Thr Glu Glu 
705                 710                 715                 720 


Arg Val Ala Ser Asp Ser Pro Lys Pro Ala Leu Thr Leu Gln Gln Gly 
                725                 730                 735     


Gln Glu Phe Ser Ala Gly Gly Gln Asn Ala Glu Asn Leu Cys Gln Phe 
            740                 745                 750         


Phe Lys Ile Ser Pro Asp Leu Asn Ile Lys Cys Glu Arg Lys Asp Asp 
        755                 760                 765             


Phe Leu Gly Ala Ala Glu Gly Lys Leu Gln Cys Asn Arg Leu Met Pro 
    770                 775                 780                 


Asn Ser Gln Lys Asp Cys His Cys Leu Gly Asp Val Leu Ile Glu Asn 
785                 790                 795                 800 


Thr Lys Glu Ser Lys Ser Gln Ser Glu Asp Leu Gly Arg Lys Pro Met 
                805                 810                 815     


Glu Ser Ser Ser Val Val Ser Cys Arg Asp Arg Lys Asp Arg Arg Arg 
            820                 825                 830         


Ser Met Cys Tyr Ser Asp Gly Arg Ser Leu His Leu Glu Lys Asn Gly 
        835                 840                 845             


Asn His Thr Pro Ser Ser Ser Val Gly Ser Ser Val Glu Ile Ser Leu 
    850                 855                 860                 


Glu Asn Ser Glu Leu Phe Lys Asp Leu Ser Asp Ala Ile Glu Gln Thr 
865                 870                 875                 880 


Phe Gln Arg Arg Asn Ser Glu Thr Lys Val Arg Arg Ser Thr Arg Leu 
                885                 890                 895     


Gln Lys Asp Leu Glu Asn Glu Gly Leu Val Trp Ile Ser Leu Pro Leu 
            900                 905                 910         


Pro Ser Thr Ser Gln Lys Ala Lys Arg Arg Thr Ile Cys Thr Phe Asp 
        915                 920                 925             


Ser Ser Gly Phe Glu Ser Met Ser Pro Ile Lys Glu Thr Val Ser Ser 
    930                 935                 940                 


Arg Gln Lys Pro Gln Met Ala Pro Pro Val Ser Asp Pro Glu Asn Ser 
945                 950                 955                 960 


Gln Gly Pro Ala Ala Gly Ser Ser Asp Glu Pro Gly Lys Arg Arg Lys 
                965                 970                 975     


Ser Phe Cys Ile Ser Thr Leu Ala Asn Thr Lys Ala Thr Ser Gln Phe 
            980                 985                 990         


Lys Gly Tyr Arg Arg Arg Ser Ser  Leu Asn Gly Lys Gly  Glu Ser Ser 
        995                 1000                 1005             


Leu Thr  Ala Leu Glu Arg Ile  Glu His Asn Gly Glu  Arg Lys Gln 
    1010                 1015                 1020             


<210> 5538
<211> 320
<212> PRT
<213> Homo sapiens

<400> 5538
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Asn Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210> 5539
<211> 46
<212> PRT
<213> Homo sapiens

<400> 5539
Met Cys Ser Leu Ala Ser Gly Ala Thr Gly Tyr Ser His Leu Leu Lys 
1               5                   10                  15      


Lys His Phe His Thr Val Ser Leu Ser Ile Ser Leu Ile Leu Thr Ala 
            20                  25                  30          


Trp Phe Ile Asn Met Asp Leu Asn Phe Met Asp Thr Leu Ser 
        35                  40                  45      


<210> 5540
<211> 65
<212> PRT
<213> Homo sapiens

<400> 5540
Met Cys Tyr Tyr Ser Asn Tyr Tyr Gly Gly Leu Arg Tyr Gly Tyr Gly 
1               5                   10                  15      


Val Leu Gly Gly Gly Tyr Gly Cys Gly Cys Gly Tyr Gly His Gly Tyr 
            20                  25                  30          


Gly Gly Leu Gly Cys Gly Tyr Gly Arg Gly Tyr Gly Gly Tyr Gly Tyr 
        35                  40                  45              


Gly Cys Cys Arg Pro Ser Cys Tyr Gly Arg Tyr Trp Ser Cys Gly Phe 
    50                  55                  60                  


Tyr 
65  


<210> 5541
<211> 2352
<212> PRT
<213> Homo sapiens

<400> 5541
Met Glu Lys Ala Thr Val Pro Val Ala Ala Ala Thr Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Thr Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Thr Ala Ser Lys Leu Leu Leu Ser Gly Thr Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Thr Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr 
                325                 330                 335     


Ala Leu Thr Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Thr Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp 
            420                 425                 430         


Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Thr Thr Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Thr Thr Leu Pro Ile Arg Asn Lys Ala Val Ser Gly Arg Ala Ser 
    770                 775                 780                 


Ala Met Ser Asn Thr Pro Thr His Ser Ile Ala Ala Ser Ile Ser Gln 
785                 790                 795                 800 


Pro Gln Thr Pro Thr Pro Ser Pro Ile Ile Ser Pro Ser Ala Met Leu 
                805                 810                 815     


Pro Ile Tyr Pro Ala Ile Asp Ile Asp Ala Gln Thr Glu Ser Asn His 
            820                 825                 830         


Asp Thr Ala Leu Thr Leu Ala Cys Ala Gly Gly His Glu Glu Leu Val 
        835                 840                 845             


Gln Thr Leu Leu Glu Arg Gly Ala Ser Ile Glu His Arg Asp Lys Lys 
    850                 855                 860                 


Gly Phe Thr Pro Leu Ile Leu Ala Ala Thr Ala Gly His Val Gly Val 
865                 870                 875                 880 


Val Glu Ile Leu Leu Asp Asn Gly Ala Asp Ile Glu Ala Gln Ser Glu 
                885                 890                 895     


Arg Thr Lys Asp Thr Pro Leu Ser Leu Ala Cys Ser Gly Gly Arg Gln 
            900                 905                 910         


Glu Val Val Glu Leu Leu Leu Ala Arg Gly Ala Asn Lys Glu His Arg 
        915                 920                 925             


Asn Val Ser Asp Tyr Thr Pro Leu Ser Leu Ala Ala Ser Gly Gly Tyr 
    930                 935                 940                 


Val Asn Ile Ile Lys Ile Leu Leu Asn Ala Gly Ala Glu Ile Asn Ser 
945                 950                 955                 960 


Arg Thr Gly Ser Lys Leu Gly Ile Ser Pro Leu Met Leu Ala Ala Met 
                965                 970                 975     


Asn Gly His Thr Ala Ala Val Lys Leu Leu Leu Asp Met Gly Ser Asp 
            980                 985                 990         


Ile Asn Ala Gln Ile Glu Thr Asn  Arg Asn Thr Ala Leu  Thr Leu Ala 
        995                 1000                 1005             


Cys Phe  Gln Gly Arg Thr Glu  Val Val Ser Leu Leu  Leu Asp Arg 
    1010                 1015                 1020             


Lys Ala  Asn Val Glu His Arg  Ala Lys Thr Gly Leu  Thr Pro Leu 
    1025                 1030                 1035             


Met Glu  Ala Ala Ser Gly Gly  Tyr Ala Glu Val Gly  Arg Val Leu 
    1040                 1045                 1050             


Leu Asp  Lys Gly Ala Asp Val  Asn Ala Pro Pro Val  Pro Ser Ser 
    1055                 1060                 1065             


Arg Asp  Thr Ala Leu Thr Ile  Ala Ala Asp Lys Gly  His Tyr Lys 
    1070                 1075                 1080             


Phe Cys  Glu Leu Leu Ile Gly  Arg Gly Ala His Ile  Asp Val Arg 
    1085                 1090                 1095             


Asn Lys  Lys Gly Asn Thr Pro  Leu Trp Leu Ala Ala  Asn Gly Gly 
    1100                 1105                 1110             


His Leu  Asp Val Val Gln Leu  Leu Val Gln Ala Gly  Ala Asp Val 
    1115                 1120                 1125             


Asp Ala  Ala Asp Asn Arg Lys  Ile Thr Pro Leu Met  Ala Ala Phe 
    1130                 1135                 1140             


Arg Lys  Gly His Val Lys Val  Val Arg Tyr Leu Val  Lys Glu Val 
    1145                 1150                 1155             


Asn Gln  Phe Pro Ser Asp Ser  Glu Cys Met Arg Tyr  Ile Ala Thr 
    1160                 1165                 1170             


Ile Thr  Asp Lys Glu Met Leu  Lys Lys Cys His Leu  Cys Met Glu 
    1175                 1180                 1185             


Ser Ile  Val Gln Ala Lys Asp  Arg Gln Ala Ala Glu  Ala Asn Lys 
    1190                 1195                 1200             


Asn Ala  Ser Ile Leu Leu Glu  Glu Leu Asp Leu Glu  Lys Leu Arg 
    1205                 1210                 1215             


Glu Glu  Ser Arg Arg Leu Ala  Leu Ala Ala Lys Arg  Glu Lys Arg 
    1220                 1225                 1230             


Lys Glu  Lys Arg Arg Lys Lys  Lys Glu Glu Gln Arg  Arg Lys Leu 
    1235                 1240                 1245             


Glu Glu  Ile Glu Ala Lys Asn  Lys Glu Asn Phe Glu  Leu Gln Ala 
    1250                 1255                 1260             


Ala Gln  Glu Lys Glu Lys Leu  Lys Val Glu Asp Glu  Pro Glu Val 
    1265                 1270                 1275             


Leu Thr  Glu Pro Pro Ser Ala  Thr Thr Thr Thr Thr  Ile Gly Ile 
    1280                 1285                 1290             


Ser Ala  Thr Trp Thr Thr Leu  Ala Gly Ser His Gly  Lys Arg Asn 
    1295                 1300                 1305             


Asn Thr  Ile Thr Thr Thr Ser  Ser Lys Arg Lys Asn  Arg Lys Asn 
    1310                 1315                 1320             


Lys Ile  Thr Pro Glu Asn Val  Gln Ile Ile Phe Asp  Asp Pro Leu 
    1325                 1330                 1335             


Pro Ile  Ser Tyr Ser Gln Pro  Glu Lys Val Asn Gly  Glu Ser Lys 
    1340                 1345                 1350             


Ser Ser  Ser Thr Ser Glu Ser  Gly Asp Ser Asp Asn  Met Arg Ile 
    1355                 1360                 1365             


Ser Ser  Cys Ser Asp Glu Ser  Ser Asn Ser Asn Ser  Ser Arg Lys 
    1370                 1375                 1380             


Ser Asp  Asn His Ser Pro Ala  Val Val Thr Thr Thr  Val Ser Ser 
    1385                 1390                 1395             


Lys Lys  Gln Pro Ser Val Leu  Val Thr Phe Pro Lys  Glu Glu Arg 
    1400                 1405                 1410             


Lys Ser  Val Ser Gly Lys Ala  Ser Ile Lys Leu Ser  Glu Thr Ile 
    1415                 1420                 1425             


Ser Glu  Gly Thr Ser Asn Ser  Leu Ser Thr Cys Thr  Lys Ser Gly 
    1430                 1435                 1440             


Pro Ser  Pro Leu Ser Ser Pro  Asn Gly Lys Leu Thr  Val Ala Ser 
    1445                 1450                 1455             


Pro Lys  Arg Gly Gln Lys Arg  Glu Glu Gly Trp Lys  Glu Val Val 
    1460                 1465                 1470             


Arg Arg  Ser Lys Lys Val Ser  Val Pro Ser Thr Val  Ile Ser Arg 
    1475                 1480                 1485             


Val Ile  Gly Arg Gly Gly Cys  Asn Ile Asn Ala Ile  Arg Glu Phe 
    1490                 1495                 1500             


Thr Gly  Ala His Ile Asp Ile  Asp Lys Gln Lys Asp  Lys Thr Gly 
    1505                 1510                 1515             


Asp Arg  Ile Ile Thr Ile Arg  Gly Gly Thr Glu Ser  Thr Arg Gln 
    1520                 1525                 1530             


Ala Thr  Gln Leu Ile Asn Ala  Leu Ile Lys Asp Pro  Asp Lys Glu 
    1535                 1540                 1545             


Ile Asp  Glu Leu Ile Pro Lys  Asn Arg Leu Lys Ser  Ser Ser Ala 
    1550                 1555                 1560             


Asn Ser  Lys Ile Gly Ser Ser  Ala Pro Thr Thr Thr  Ala Ala Asn 
    1565                 1570                 1575             


Thr Ser  Leu Met Gly Ile Lys  Met Thr Thr Val Ala  Leu Ser Ser 
    1580                 1585                 1590             


Thr Ser  Gln Thr Ala Thr Ala  Leu Thr Val Pro Ala  Ile Ser Ser 
    1595                 1600                 1605             


Ala Ser  Thr His Lys Thr Ile  Lys Asn Pro Val Asn  Asn Val Arg 
    1610                 1615                 1620             


Pro Gly  Phe Pro Val Ser Leu  Pro Leu Ala Tyr Pro  Pro Pro Gln 
    1625                 1630                 1635             


Phe Ala  His Ala Leu Leu Ala  Ala Gln Thr Phe Gln  Gln Ile Arg 
    1640                 1645                 1650             


Pro Pro  Arg Leu Pro Met Thr  His Phe Gly Gly Thr  Phe Pro Pro 
    1655                 1660                 1665             


Ala Gln  Ser Thr Trp Gly Pro  Phe Pro Val Arg Pro  Leu Ser Pro 
    1670                 1675                 1680             


Ala Arg  Ala Thr Asn Ser Pro  Lys Pro His Met Val  Pro Arg His 
    1685                 1690                 1695             


Ser Asn  Gln Asn Ser Ser Gly  Ser Gln Val Asn Ser  Ala Gly Ser 
    1700                 1705                 1710             


Leu Thr  Ser Ser Pro Thr Thr  Thr Thr Ser Ser Ser  Ala Ser Thr 
    1715                 1720                 1725             


Val Pro  Gly Thr Ser Thr Asn  Gly Ser Pro Ser Ser  Pro Ser Val 
    1730                 1735                 1740             


Arg Arg  Gln Leu Phe Val Thr  Val Val Lys Thr Ser  Asn Ala Thr 
    1745                 1750                 1755             


Thr Thr  Thr Val Thr Thr Thr  Ala Ser Asn Asn Asn  Thr Ala Pro 
    1760                 1765                 1770             


Thr Asn  Ala Thr Tyr Pro Met  Pro Thr Ala Lys Glu  His Tyr Pro 
    1775                 1780                 1785             


Val Ser  Ser Pro Ser Ser Pro  Ser Pro Pro Ala Gln  Pro Gly Gly 
    1790                 1795                 1800             


Val Ser  Arg Asn Ser Pro Leu  Asp Cys Gly Ser Ala  Ser Pro Asn 
    1805                 1810                 1815             


Lys Val  Ala Ser Ser Ser Glu  Gln Glu Ala Gly Ser  Pro Pro Val 
    1820                 1825                 1830             


Val Glu  Thr Thr Asn Thr Arg  Pro Pro Asn Ser Ser  Ser Ser Ser 
    1835                 1840                 1845             


Gly Ser  Ser Ser Ala His Ser  Asn Gln Gln Gln Pro  Pro Gly Ser 
    1850                 1855                 1860             


Val Ser  Gln Glu Pro Arg Pro  Pro Leu Gln Gln Ser  Gln Val Pro 
    1865                 1870                 1875             


Pro Pro  Glu Val Arg Met Thr  Val Pro Pro Leu Ala  Thr Ser Ser 
    1880                 1885                 1890             


Ala Pro  Val Ala Val Pro Ser  Thr Ala Pro Val Thr  Tyr Pro Met 
    1895                 1900                 1905             


Pro Gln  Thr Pro Met Gly Cys  Pro Gln Pro Thr Pro  Lys Met Glu 
    1910                 1915                 1920             


Thr Pro  Ala Ile Arg Pro Pro  Pro His Gly Thr Thr  Ala Pro His 
    1925                 1930                 1935             


Lys Asn  Ser Ala Ser Val Gln  Asn Ser Ser Val Ala  Val Leu Ser 
    1940                 1945                 1950             


Val Asn  His Ile Lys Arg Pro  His Ser Val Pro Ser  Ser Val Gln 
    1955                 1960                 1965             


Leu Pro  Ser Thr Leu Ser Thr  Gln Ser Ala Cys Gln  Asn Ser Val 
    1970                 1975                 1980             


His Pro  Ala Asn Lys Pro Ile  Ala Pro Asn Phe Ser  Ala Pro Leu 
    1985                 1990                 1995             


Pro Phe  Gly Pro Phe Ser Thr  Leu Phe Glu Asn Ser  Pro Thr Ser 
    2000                 2005                 2010             


Ala His  Ala Phe Trp Gly Gly  Ser Val Val Ser Ser  Gln Ser Thr 
    2015                 2020                 2025             


Pro Glu  Ser Met Leu Ser Gly  Lys Ser Ser Tyr Leu  Pro Asn Ser 
    2030                 2035                 2040             


Asp Pro  Leu His Gln Ser Asp  Thr Ser Lys Ala Pro  Gly Phe Arg 
    2045                 2050                 2055             


Pro Pro  Leu Gln Arg Pro Ala  Pro Ser Pro Ser Gly  Ile Val Asn 
    2060                 2065                 2070             


Met Asp  Ser Pro Tyr Gly Ser  Val Thr Pro Ser Ser  Thr His Leu 
    2075                 2080                 2085             


Gly Asn  Phe Ala Ser Asn Ile  Ser Gly Gly Gln Met  Tyr Gly Pro 
    2090                 2095                 2100             


Gly Ala  Pro Leu Gly Gly Ala  Pro Ala Ala Ala Asn  Phe Asn Arg 
    2105                 2110                 2115             


Gln His  Phe Ser Pro Leu Ser  Leu Leu Thr Pro Cys  Ser Ser Ala 
    2120                 2125                 2130             


Ser Asn  Asp Ser Ser Ala Gln  Ser Val Ser Ser Gly  Val Arg Ala 
    2135                 2140                 2145             


Pro Ser  Pro Ala Pro Ser Ser  Val Pro Leu Gly Ser  Glu Lys Pro 
    2150                 2155                 2160             


Ser Asn  Val Ser Gln Asp Arg  Lys Val Pro Val Pro  Ile Gly Thr 
    2165                 2170                 2175             


Glu Arg  Ser Ala Arg Ile Arg  Gln Thr Gly Thr Ser  Ala Pro Ser 
    2180                 2185                 2190             


Val Ile  Gly Ser Asn Leu Ser  Thr Ser Val Gly His  Ser Gly Ile 
    2195                 2200                 2205             


Trp Ser  Phe Glu Gly Ile Gly  Gly Asn Gln Asp Lys  Val Asp Trp 
    2210                 2215                 2220             


Cys Asn  Pro Gly Met Gly Asn  Pro Met Ile His Arg  Pro Met Ser 
    2225                 2230                 2235             


Asp Pro  Gly Val Phe Ser Gln  His Gln Ala Met Glu  Arg Asp Ser 
    2240                 2245                 2250             


Thr Gly  Ile Val Thr Pro Ser  Gly Thr Phe His Gln  His Val Pro 
    2255                 2260                 2265             


Ala Gly  Tyr Met Asp Phe Pro  Lys Val Gly Gly Met  Pro Phe Ser 
    2270                 2275                 2280             


Val Tyr  Gly Asn Ala Met Ile  Pro Pro Val Ala Pro  Ile Pro Asp 
    2285                 2290                 2295             


Gly Ala  Gly Gly Pro Ile Phe  Asn Gly Pro His Ala  Ala Asp Pro 
    2300                 2305                 2310             


Ser Trp  Asn Ser Leu Ile Lys  Met Val Ser Ser Ser  Thr Glu Asn 
    2315                 2320                 2325             


Asn Gly  Pro Gln Thr Val Trp  Thr Gly Pro Trp Ala  Pro His Met 
    2330                 2335                 2340             


Asn Ser  Val His Met Asn Gln  Leu Gly 
    2345                 2350         


<210> 5542
<211> 457
<212> PRT
<213> Homo sapiens

<400> 5542
Met Ser Gly Thr Arg Ala Ser Asn Asp Arg Pro Pro Gly Ala Gly Gly 
1               5                   10                  15      


Val Lys Arg Gly Arg Leu Gln Gln Glu Ala Ala Ala Thr Gly Ser Arg 
            20                  25                  30          


Val Thr Val Val Leu Gly Ala Gln Trp Gly Asp Glu Gly Lys Gly Lys 
        35                  40                  45              


Val Val Asp Leu Leu Ala Thr Asp Ala Asp Ile Ile Ser Arg Cys Gln 
    50                  55                  60                  


Gly Gly Asn Asn Ala Gly His Thr Val Val Val Asp Gly Lys Glu Tyr 
65                  70                  75                  80  


Asp Phe His Leu Leu Pro Ser Gly Ile Ile Asn Thr Lys Ala Val Ser 
                85                  90                  95      


Phe Ile Gly Asn Gly Val Val Ile His Leu Pro Gly Leu Phe Glu Glu 
            100                 105                 110         


Ala Glu Lys Asn Glu Lys Lys Gly Leu Lys Asp Trp Glu Lys Arg Leu 
        115                 120                 125             


Ile Ile Ser Asp Arg Ala His Leu Val Phe Asp Phe His Gln Ala Val 
    130                 135                 140                 


Asp Gly Leu Gln Glu Val Gln Arg Gln Ala Gln Glu Gly Lys Asn Ile 
145                 150                 155                 160 


Gly Thr Thr Lys Lys Gly Ile Gly Pro Thr Tyr Ser Ser Lys Ala Ala 
                165                 170                 175     


Arg Thr Gly Leu Arg Ile Cys Asp Leu Leu Ser Asp Phe Asp Glu Phe 
            180                 185                 190         


Ser Ser Arg Phe Lys Asn Leu Ala His Gln His Gln Ser Met Phe Pro 
        195                 200                 205             


Thr Leu Glu Ile Asp Ile Glu Gly Gln Leu Lys Arg Leu Lys Gly Phe 
    210                 215                 220                 


Ala Glu Arg Ile Arg Pro Met Val Arg Asp Gly Val Tyr Phe Met Tyr 
225                 230                 235                 240 


Glu Ala Leu His Gly Pro Pro Lys Lys Ile Leu Val Glu Gly Ala Asn 
                245                 250                 255     


Ala Ala Leu Leu Asp Ile Asp Phe Gly Thr Tyr Pro Phe Val Thr Ser 
            260                 265                 270         


Ser Asn Cys Thr Val Gly Gly Val Cys Thr Gly Leu Gly Ile Pro Pro 
        275                 280                 285             


Gln Asn Ile Gly Asp Val Tyr Gly Val Val Lys Ala Tyr Thr Thr Arg 
    290                 295                 300                 


Val Gly Ile Gly Ala Phe Pro Thr Glu Gln Ile Asn Glu Ile Gly Gly 
305                 310                 315                 320 


Leu Leu Gln Thr Arg Gly His Glu Trp Gly Val Thr Thr Gly Arg Lys 
                325                 330                 335     


Arg Arg Cys Gly Trp Leu Asp Leu Met Ile Leu Arg Tyr Ala His Met 
            340                 345                 350         


Val Asn Gly Phe Thr Ala Leu Ala Leu Thr Lys Leu Asp Ile Leu Asp 
        355                 360                 365             


Val Leu Gly Glu Val Lys Val Gly Val Ser Tyr Lys Leu Asn Gly Lys 
    370                 375                 380                 


Arg Ile Pro Tyr Phe Pro Ala Asn Gln Glu Met Leu Gln Lys Val Glu 
385                 390                 395                 400 


Val Glu Tyr Glu Thr Leu Pro Gly Trp Lys Ala Asp Thr Thr Gly Ala 
                405                 410                 415     


Arg Arg Trp Glu Asp Leu Pro Pro Gln Ala Gln Asn Tyr Ile Arg Phe 
            420                 425                 430         


Val Glu Asn His Val Gly Val Ala Val Lys Trp Val Gly Val Gly Lys 
        435                 440                 445             


Ser Arg Glu Ser Met Ile Gln Leu Phe 
    450                 455         


<210> 5543
<211> 531
<212> PRT
<213> Homo sapiens

<400> 5543
Met Cys Ser Leu Ala Ser Gly Ala Thr Gly Gly Arg Gly Ala Val Glu 
1               5                   10                  15      


Asn Glu Glu Asp Leu Pro Glu Leu Ser Asp Ser Gly Asp Glu Ala Ala 
            20                  25                  30          


Trp Glu Asp Glu Asp Asp Ala Asp Leu Pro His Gly Lys Gln Gln Thr 
        35                  40                  45              


Pro Cys Leu Phe Cys Asn Arg Leu Phe Thr Ser Ala Glu Glu Thr Phe 
    50                  55                  60                  


Ser His Cys Lys Ser Glu His Gln Phe Asn Ile Asp Ser Met Val His 
65                  70                  75                  80  


Lys His Gly Leu Glu Phe Tyr Gly Tyr Ile Lys Leu Ile Asn Phe Ile 
                85                  90                  95      


Arg Leu Lys Asn Pro Thr Val Glu Tyr Met Asn Ser Ile Tyr Asn Pro 
            100                 105                 110         


Val Pro Trp Glu Lys Glu Glu Tyr Leu Lys Pro Val Leu Glu Asp Asp 
        115                 120                 125             


Leu Leu Leu Gln Phe Asp Val Glu Asp Leu Tyr Glu Pro Val Ser Val 
    130                 135                 140                 


Pro Phe Ser Tyr Pro Asn Gly Leu Ser Glu Asn Thr Ser Val Val Glu 
145                 150                 155                 160 


Lys Leu Lys His Met Glu Ala Arg Ala Leu Ser Ala Glu Ala Ala Leu 
                165                 170                 175     


Ala Arg Ala Arg Glu Asp Leu Gln Lys Met Lys Gln Phe Ala Gln Asp 
            180                 185                 190         


Phe Val Met His Thr Asp Val Arg Thr Cys Ser Ser Ser Thr Ser Val 
        195                 200                 205             


Ile Ala Asp Leu Gln Glu Asp Glu Asp Gly Val Tyr Phe Ser Ser Tyr 
    210                 215                 220                 


Gly His Tyr Gly Ile His Glu Glu Met Leu Lys Asp Lys Ile Arg Thr 
225                 230                 235                 240 


Glu Ser Tyr Arg Asp Phe Ile Tyr Gln Asn Pro His Ile Phe Lys Asp 
                245                 250                 255     


Lys Val Val Leu Asp Val Gly Cys Gly Thr Gly Ile Leu Ser Met Phe 
            260                 265                 270         


Ala Ala Lys Ala Gly Ala Lys Lys Val Leu Gly Val Asp Gln Ser Glu 
        275                 280                 285             


Ile Leu Tyr Gln Ala Met Asp Ile Ile Arg Leu Asn Lys Leu Glu Asp 
    290                 295                 300                 


Thr Ile Thr Leu Ile Lys Gly Lys Ile Glu Glu Val His Leu Pro Val 
305                 310                 315                 320 


Glu Lys Val Asp Val Ile Ile Ser Glu Trp Met Gly Tyr Phe Leu Leu 
                325                 330                 335     


Phe Glu Ser Met Leu Asp Ser Val Leu Tyr Ala Lys Asn Lys Tyr Leu 
            340                 345                 350         


Ala Lys Gly Gly Ser Val Tyr Pro Asp Ile Cys Thr Ile Ser Leu Val 
        355                 360                 365             


Ala Val Ser Asp Val Asn Lys His Ala Asp Arg Ile Ala Phe Trp Asp 
    370                 375                 380                 


Asp Val Tyr Gly Phe Lys Met Ser Cys Met Lys Lys Ala Val Ile Pro 
385                 390                 395                 400 


Glu Ala Val Val Glu Val Leu Asp Pro Lys Thr Leu Ile Ser Glu Pro 
                405                 410                 415     


Cys Gly Ile Lys His Ile Asp Cys His Thr Thr Ser Ile Ser Asp Leu 
            420                 425                 430         


Glu Phe Ser Ser Asp Phe Thr Leu Lys Ile Thr Arg Thr Ser Met Cys 
        435                 440                 445             


Thr Ala Ile Ala Gly Tyr Phe Asp Ile Tyr Phe Glu Lys Asn Cys His 
    450                 455                 460                 


Asn Arg Val Val Phe Ser Thr Gly Pro Gln Ser Thr Lys Thr His Trp 
465                 470                 475                 480 


Lys Gln Thr Val Phe Leu Leu Glu Lys Pro Phe Ser Val Lys Ala Gly 
                485                 490                 495     


Glu Ala Leu Lys Gly Lys Val Thr Val His Lys Ser Lys Lys Asp Pro 
            500                 505                 510         


Arg Ser Leu Thr Val Thr Leu Thr Leu Asn Asn Ser Thr Gln Thr Tyr 
        515                 520                 525             


Gly Leu Gln 
    530     


<210> 5544
<211> 552
<212> PRT
<213> Homo sapiens

<400> 5544
Met Ser Val Leu Ser Pro Gly Asp Leu Lys Pro Lys Arg Gly Ser Pro 
1               5                   10                  15      


His Arg Gly Ser Leu Asp Arg Thr Asp Ala Ser Thr Asp Leu Ala Met 
            20                  25                  30          


Arg Ser Trp Pro Ser Glu Leu Gly Ser Arg Thr Cys Ser Thr Ser Ala 
        35                  40                  45              


Thr Thr Thr Ala Pro Ser Asn Ser Thr Pro Ile Ala Arg His Pro Gly 
    50                  55                  60                  


Arg Thr Lys Gly Tyr Asn Ser Asp Asp Asn Leu Cys Glu Pro Ser Leu 
65                  70                  75                  80  


Glu Phe Glu Val Pro Asn His Arg Gln Tyr Val Ser Arg Pro Ser Ser 
                85                  90                  95      


Leu Glu Ser Ser Arg Asn Thr Ser Ser Asn Ser Ser Pro Leu Asn Leu 
            100                 105                 110         


Lys Gly Ser Ser Glu Gln Leu His Gly Arg Ser Glu Ser Phe Ser Ser 
        115                 120                 125             


Glu Asp Leu Ile Pro Ser Arg Asp Leu Ala Thr Leu Pro Arg Glu Ala 
    130                 135                 140                 


Ser Thr Pro Gly Arg Asn Ala Leu Gly Arg His Glu Tyr Pro Leu Pro 
145                 150                 155                 160 


Arg Asn Gly Pro Leu Pro Gln Glu Gly Ala Gln Lys Arg Gly Thr Ala 
                165                 170                 175     


Pro Pro Tyr Val Gly Val Arg Pro Cys Ser Ala Ser Pro Ser Ser Glu 
            180                 185                 190         


Met Val Thr Leu Glu Glu Phe Leu Glu Glu Ser Asn Arg Ser Ser Pro 
        195                 200                 205             


Thr His Asp Thr Pro Ser Cys Arg Asp Asp Leu Leu Ser Asp Tyr Phe 
    210                 215                 220                 


Arg Lys Ala Ser Asp Pro Pro Ala Ile Gly Gly Gln Pro Gly Pro Pro 
225                 230                 235                 240 


Ala Lys Lys Glu Gly Ala Lys Met Pro Thr Asn Phe Val Ala Pro Thr 
                245                 250                 255     


Val Lys Met Ala Ala Pro Thr Ser Glu Gly Arg Pro Leu Lys Pro Gly 
            260                 265                 270         


Gln Tyr Val Lys Pro Asn Phe Arg Leu Thr Glu Ala Glu Ala Pro Pro 
        275                 280                 285             


Ser Val Ala Pro Arg Gln Ala Gln Pro Pro Gln Ser Leu Ser Leu Gly 
    290                 295                 300                 


Arg Pro Arg Gln Ala Pro Val Pro Pro Ala Ser His Ala Pro Ala Ser 
305                 310                 315                 320 


Arg Ser Ala Ser Leu Ser Arg Ala Phe Ser Leu Ala Ser Ala Asp Leu 
                325                 330                 335     


Leu Arg Ala Ser Gly Pro Glu Ala Cys Lys Gln Glu Ser Pro Gln Lys 
            340                 345                 350         


Leu Gly Ala Pro Glu Ala Leu Gly Gly Arg Glu Thr Gly Ser His Thr 
        355                 360                 365             


Leu Gln Ser Pro Ala Pro Pro Ser Ser His Ser Leu Ala Arg Glu Arg 
    370                 375                 380                 


Thr Pro Leu Val Gly Lys Ala Gly Ser Ser Cys Gln Gly Pro Gly Pro 
385                 390                 395                 400 


Arg Ser Arg Pro Leu Asp Thr Arg Arg Phe Ser Leu Ala Pro Pro Lys 
                405                 410                 415     


Glu Glu Arg Leu Ala Pro Leu His Gln Ser Ala Thr Ala Pro Ala Ile 
            420                 425                 430         


Ala Thr Ala Gly Ala Gly Ala Ala Ala Ala Gly Ser Gly Ser Asn Ser 
        435                 440                 445             


Gln Leu Leu His Phe Ser Pro Ala Ala Ala Pro Ala Ala Arg Thr Lys 
    450                 455                 460                 


Pro Lys Ala Pro Pro Arg Ser Gly Glu Val Ala Thr Ile Thr Pro Val 
465                 470                 475                 480 


Arg Ala Gly Leu Ser Leu Ser Glu Gly Asp Gly Val Pro Gly Gln Gly 
                485                 490                 495     


Cys Ser Glu Gly Leu Pro Ala Lys Ser Pro Gly Arg Ser Pro Asp Leu 
            500                 505                 510         


Ala Pro His Leu Gly Arg Ala Leu Glu Asp Cys Ser Arg Gly Ser Val 
        515                 520                 525             


Ser Lys Ser Ser Pro Ala Ser Pro Glu Pro Gly Gly Asp Pro Gln Thr 
    530                 535                 540                 


Val Trp Tyr Glu Tyr Gly Cys Val 
545                 550         


<210> 5545
<211> 257
<212> PRT
<213> Homo sapiens

<400> 5545
Met Ala Asp Lys Met Asp Met Ser Leu Asp Asp Ile Ile Lys Leu Asn 
1               5                   10                  15      


Arg Ser Gln Arg Gly Gly Arg Gly Gly Gly Arg Gly Arg Gly Arg Ala 
            20                  25                  30          


Gly Ser Gln Gly Gly Arg Gly Gly Gly Ala Gln Ala Ala Ala Arg Val 
        35                  40                  45              


Asn Arg Gly Gly Gly Pro Ile Arg Asn Arg Pro Ala Ile Ala Arg Gly 
    50                  55                  60                  


Ala Ala Gly Gly Gly Gly Arg Asn Arg Pro Ala Pro Tyr Ser Arg Pro 
65                  70                  75                  80  


Lys Gln Leu Pro Asp Lys Trp Gln His Asp Leu Phe Asp Ser Gly Phe 
                85                  90                  95      


Gly Gly Gly Ala Gly Val Glu Thr Gly Gly Lys Leu Leu Val Ser Asn 
            100                 105                 110         


Leu Asp Phe Gly Val Ser Asp Ala Asp Ile Gln Glu Leu Phe Ala Glu 
        115                 120                 125             


Phe Gly Thr Leu Lys Lys Ala Ala Val His Tyr Asp Arg Ser Gly Arg 
    130                 135                 140                 


Ser Leu Gly Thr Ala Asp Val His Phe Glu Arg Lys Ala Asp Ala Leu 
145                 150                 155                 160 


Lys Ala Met Lys Gln Tyr Asn Gly Val Pro Leu Asp Gly Arg Pro Met 
                165                 170                 175     


Asn Ile Gln Leu Val Thr Ser Gln Ile Asp Ala Gln Arg Arg Pro Ala 
            180                 185                 190         


Gln Ser Val Asn Arg Gly Gly Met Thr Arg Asn Arg Gly Ala Gly Gly 
        195                 200                 205             


Phe Gly Gly Gly Gly Gly Thr Arg Arg Gly Thr Arg Gly Gly Ala Arg 
    210                 215                 220                 


Gly Arg Gly Arg Gly Ala Gly Arg Asn Ser Lys Gln Gln Leu Ser Ala 
225                 230                 235                 240 


Glu Glu Leu Asp Ala Gln Leu Asp Ala Tyr Asn Ala Arg Met Asp Thr 
                245                 250                 255     


Ser 
    


<210> 5546
<211> 291
<212> PRT
<213> Homo sapiens

<400> 5546
Met Gly Val Ala Ala Arg Pro Pro Ala Leu Arg His Trp Phe Ser His 
1               5                   10                  15      


Ser Ile Pro Leu Ala Ile Phe Ala Leu Leu Leu Leu Tyr Leu Ser Val 
            20                  25                  30          


Arg Ser Leu Gly Ala Arg Ser Gly Cys Gly Pro Arg Ala Gln Pro Cys 
        35                  40                  45              


Val Pro Gly Glu Thr Ala Pro Phe Gln Val Arg Gln Glu Ser Gly Thr 
    50                  55                  60                  


Leu Glu Ala Pro Glu Arg Lys Gln Pro Pro Cys Leu Gly Pro Arg Gly 
65                  70                  75                  80  


Met Leu Gly Arg Met Met Arg Arg Phe His Ala Ser Leu Lys Pro Glu 
                85                  90                  95      


Gly Asp Val Gly Leu Ser Pro Tyr Leu Ala Gly Trp Arg Ala Leu Val 
            100                 105                 110         


Glu Phe Leu Thr Pro Leu Gly Ser Val Phe Ala Phe Ala Thr Arg Glu 
        115                 120                 125             


Ala Phe Thr Lys Val Thr Asp Leu Glu Ala Arg Val His Gly Pro Asp 
    130                 135                 140                 


Ala Glu His Tyr Trp Ser Leu Val Ala Met Ala Ala Trp Glu Arg Arg 
145                 150                 155                 160 


Ala Gly Leu Leu Glu Gln Pro Gly Ala Ala Pro Arg Asp Pro Thr Arg 
                165                 170                 175     


Ser Ser Gly Ser Arg Thr Leu Leu Leu Leu His Arg Ala Leu Arg Trp 
            180                 185                 190         


Ser Gln Leu Cys Leu His Arg Val Ala Thr Gly Ala Leu Gly Gly Pro 
        195                 200                 205             


Asp Ala Gly Val Gln Cys Ser Asp Ala Tyr Arg Ala Ala Leu Gly Pro 
    210                 215                 220                 


His His Pro Trp Leu Val Arg Gln Thr Ala Arg Leu Ala Phe Leu Ala 
225                 230                 235                 240 


Phe Pro Gly Arg Arg Arg Leu Leu Glu Leu Ala Cys Pro Gly Ala Thr 
                245                 250                 255     


Glu Ala Glu Ala Arg Ala Ala Leu Val Arg Ala Ala Gly Thr Leu Glu 
            260                 265                 270         


Asp Val Tyr Asn Arg Thr Gln Ser Leu Leu Ala Glu Arg Gly Leu Leu 
        275                 280                 285             


Gln Leu Ala 
    290     


<210> 5547
<211> 1100
<212> PRT
<213> Homo sapiens

<400> 5547
Met Gly Asn Ala Ala Gly Ser Ala Glu Gln Pro Ala Gly Pro Ala Ala 
1               5                   10                  15      


Pro Pro Pro Lys Gln Pro Ala Pro Pro Lys Gln Pro Met Pro Ala Ala 
            20                  25                  30          


Gly Glu Leu Glu Glu Arg Phe Asn Arg Ala Leu Asn Cys Met Asn Leu 
        35                  40                  45              


Pro Pro Asp Lys Val Gln Leu Leu Ser Gln Tyr Asp Asn Glu Lys Lys 
    50                  55                  60                  


Trp Glu Leu Ile Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro 
65                  70                  75                  80  


Ala Ala Tyr Ile Gln Lys Leu Lys Ser Tyr Val Asp Thr Gly Gly Val 
                85                  90                  95      


Ser Arg Lys Val Ala Ala Asp Trp Met Ser Asn Leu Gly Phe Lys Arg 
            100                 105                 110         


Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Thr Ser Leu 
        115                 120                 125             


Arg Thr Asn His Ile Gly Trp Val Gln Glu Phe Leu Asn Glu Glu Asn 
    130                 135                 140                 


Arg Gly Leu Asp Val Leu Leu Glu Tyr Leu Ala Phe Ala Gln Cys Ser 
145                 150                 155                 160 


Val Thr Tyr Asp Met Glu Ser Thr Asp Asn Gly Ala Ser Asn Ser Glu 
                165                 170                 175     


Lys Asn Lys Pro Leu Glu Gln Ser Val Glu Asp Leu Ser Lys Gly Pro 
            180                 185                 190         


Pro Ser Ser Val Pro Lys Ser Arg His Leu Thr Ile Lys Leu Thr Pro 
        195                 200                 205             


Ala His Ser Arg Lys Ala Leu Arg Asn Ser Arg Ile Val Ser Gln Lys 
    210                 215                 220                 


Asp Asp Val His Val Cys Ile Met Cys Leu Arg Ala Ile Met Asn Tyr 
225                 230                 235                 240 


Gln Ser Gly Phe Ser Leu Val Met Asn His Pro Ala Cys Val Asn Glu 
                245                 250                 255     


Ile Ala Leu Ser Leu Asn Asn Lys Asn Pro Arg Thr Lys Ala Leu Val 
            260                 265                 270         


Leu Glu Leu Leu Ala Ala Val Cys Leu Val Arg Gly Gly His Asp Ile 
        275                 280                 285             


Ile Leu Ala Ala Phe Asp Asn Phe Lys Glu Val Cys Gly Glu Gln His 
    290                 295                 300                 


Arg Phe Glu Lys Leu Met Glu Tyr Phe Arg Asn Glu Asp Ser Asn Ile 
305                 310                 315                 320 


Asp Phe Met Val Ala Cys Met Gln Phe Ile Asn Ile Val Val His Ser 
                325                 330                 335     


Val Glu Asn Met Asn Phe Arg Val Phe Leu Gln Tyr Glu Phe Thr His 
            340                 345                 350         


Leu Gly Leu Asp Leu Tyr Leu Glu Arg Leu Arg Leu Thr Glu Ser Asp 
        355                 360                 365             


Lys Leu Gln Val Gln Ile Gln Ala Tyr Leu Asp Asn Ile Phe Asp Val 
    370                 375                 380                 


Gly Ala Leu Leu Glu Asp Thr Glu Thr Lys Asn Ala Val Leu Glu His 
385                 390                 395                 400 


Met Glu Glu Leu Gln Glu Gln Val Ala Leu Leu Thr Glu Arg Leu Arg 
                405                 410                 415     


Asp Ala Glu Asn Glu Ser Met Ala Lys Ile Ala Glu Leu Glu Lys Gln 
            420                 425                 430         


Leu Ser Gln Ala Arg Lys Glu Leu Glu Thr Leu Arg Glu Arg Phe Ser 
        435                 440                 445             


Glu Ser Thr Ala Met Gly Pro Ser Arg Arg Pro Pro Glu Pro Glu Lys 
    450                 455                 460                 


Ala Pro Pro Ala Ala Pro Thr Arg Pro Ser Ala Leu Glu Leu Lys Val 
465                 470                 475                 480 


Glu Glu Leu Glu Glu Lys Gly Leu Ile Arg Ile Leu Arg Gly Pro Gly 
                485                 490                 495     


Asp Ala Val Ser Ile Glu Ile Leu Pro Val Ala Val Ala Thr Pro Ser 
            500                 505                 510         


Gly Gly Asp Ala Pro Thr Pro Gly Val Pro Thr Gly Ser Pro Ser Pro 
        515                 520                 525             


Asp Leu Ala Pro Ala Ala Glu Pro Ala Pro Gly Ala Ala Pro Pro Pro 
    530                 535                 540                 


Pro Pro Pro Leu Pro Gly Leu Pro Ser Pro Gln Glu Ala Pro Pro Ser 
545                 550                 555                 560 


Ala Pro Pro Gln Ala Pro Pro Leu Pro Gly Ser Pro Glu Pro Pro Pro 
                565                 570                 575     


Ala Pro Pro Leu Pro Gly Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            580                 585                 590         


Pro Pro Pro Gly Thr Asp Gly Pro Val Pro Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Pro Pro Pro Pro Gly Gly Pro Pro Asp Ala Leu Gly Arg Arg Asp Ser 
    610                 615                 620                 


Glu Leu Gly Pro Gly Val Lys Ala Lys Lys Pro Ile Gln Thr Lys Phe 
625                 630                 635                 640 


Arg Met Pro Leu Leu Asn Trp Val Ala Leu Lys Pro Ser Gln Ile Thr 
                645                 650                 655     


Gly Thr Val Phe Thr Glu Leu Asn Asp Glu Lys Val Leu Gln Glu Leu 
            660                 665                 670         


Asp Met Ser Asp Phe Glu Glu Gln Phe Lys Thr Lys Ser Gln Gly Pro 
        675                 680                 685             


Ser Leu Asp Leu Ser Ala Leu Lys Ser Lys Ala Ala Gln Lys Ala Pro 
    690                 695                 700                 


Ser Lys Ala Thr Leu Ile Glu Ala Asn Arg Ala Lys Asn Leu Ala Ile 
705                 710                 715                 720 


Thr Leu Arg Lys Gly Asn Leu Gly Ala Glu Arg Ile Cys Gln Ala Ile 
                725                 730                 735     


Glu Ala Tyr Asp Leu Gln Ala Leu Gly Leu Asp Phe Leu Glu Leu Leu 
            740                 745                 750         


Met Arg Phe Leu Pro Thr Glu Tyr Glu Arg Ser Leu Ile Thr Arg Phe 
        755                 760                 765             


Glu Arg Glu Gln Arg Pro Met Glu Glu Leu Ser Glu Glu Asp Arg Phe 
    770                 775                 780                 


Met Leu Cys Phe Ser Arg Ile Pro Arg Leu Pro Glu Arg Met Thr Thr 
785                 790                 795                 800 


Leu Thr Phe Leu Gly Asn Phe Pro Asp Thr Ala Gln Leu Leu Met Pro 
                805                 810                 815     


Gln Leu Asn Ala Ile Ile Ala Ala Ser Met Ser Ile Lys Ser Ser Asp 
            820                 825                 830         


Lys Leu Arg Gln Ile Leu Glu Ile Val Leu Ala Phe Gly Asn Tyr Met 
        835                 840                 845             


Asn Ser Ser Lys Arg Gly Ala Ala Tyr Gly Phe Arg Leu Gln Ser Leu 
    850                 855                 860                 


Asp Ala Leu Leu Glu Met Lys Ser Thr Asp Arg Lys Gln Thr Leu Leu 
865                 870                 875                 880 


His Tyr Leu Val Lys Val Ile Ala Glu Lys Tyr Pro Gln Leu Thr Gly 
                885                 890                 895     


Phe His Ser Asp Leu His Phe Leu Asp Lys Ala Gly Ser Val Ser Leu 
            900                 905                 910         


Asp Ser Val Leu Ala Asp Val Arg Ser Leu Gln Arg Gly Leu Glu Leu 
        915                 920                 925             


Thr Gln Arg Glu Phe Val Arg Gln Asp Asp Cys Met Val Leu Lys Glu 
    930                 935                 940                 


Phe Leu Arg Ala Asn Ser Pro Thr Met Asp Lys Leu Leu Ala Asp Ser 
945                 950                 955                 960 


Lys Thr Ala Gln Glu Ala Phe Glu Ser Val Val Glu Tyr Phe Gly Glu 
                965                 970                 975     


Asn Pro Lys Thr Thr Ser Pro Gly Leu Phe Phe Ser Leu Phe Ser Arg 
            980                 985                 990         


Phe Ile Lys Ala Tyr Lys Lys Ala  Glu Gln Glu Val Glu  Gln Trp Lys 
        995                 1000                 1005             


Lys Glu  Ala Ala Ala Gln Glu  Ala Gly Ala Asp Thr  Pro Gly Lys 
    1010                 1015                 1020             


Gly Glu  Pro Pro Ala Pro Lys  Ser Pro Pro Lys Ala  Arg Arg Pro 
    1025                 1030                 1035             


Gln Met  Asp Leu Ile Ser Glu  Leu Lys Arg Arg Gln  Gln Lys Glu 
    1040                 1045                 1050             


Pro Leu  Ile Tyr Glu Ser Asp  Arg Asp Gly Ala Ile  Glu Asp Ile 
    1055                 1060                 1065             


Ile Thr  Val Ile Lys Thr Val  Pro Phe Thr Ala Arg  Thr Gly Lys 
    1070                 1075                 1080             


Arg Thr  Ser Arg Leu Leu Cys  Glu Ala Ser Leu Gly  Glu Glu Met 
    1085                 1090                 1095             


Pro Leu  
    1100 


<210> 5548
<211> 612
<212> PRT
<213> Homo sapiens

<400> 5548
Met Glu Asn Gln Leu Ala Lys Ser Thr Glu Glu Arg Thr Phe Gln Tyr 
1               5                   10                  15      


Gln Asp Ser Leu Pro Ser Leu Pro Val Pro Ser Leu Glu Glu Ser Leu 
            20                  25                  30          


Lys Lys Tyr Leu Glu Ser Val Lys Pro Phe Ala Asn Gln Glu Glu Tyr 
        35                  40                  45              


Lys Lys Thr Glu Glu Ile Val Gln Lys Phe Gln Ser Gly Ile Gly Glu 
    50                  55                  60                  


Lys Leu His Gln Lys Leu Leu Glu Arg Ala Lys Gly Lys Arg Asn Trp 
65                  70                  75                  80  


Leu Glu Glu Trp Trp Leu Asn Val Ala Tyr Leu Asp Val Arg Ile Pro 
                85                  90                  95      


Ser Gln Leu Asn Val Asn Phe Ala Gly Pro Ala Ala His Phe Glu His 
            100                 105                 110         


Tyr Trp Pro Pro Lys Glu Gly Thr Gln Leu Glu Arg Gly Ser Ile Thr 
        115                 120                 125             


Leu Trp His Asn Leu Asn Tyr Trp Gln Leu Leu Arg Lys Glu Lys Val 
    130                 135                 140                 


Pro Val His Lys Val Gly Asn Thr Pro Leu Asp Met Asn Gln Phe Arg 
145                 150                 155                 160 


Met Leu Phe Ser Thr Cys Lys Val Pro Gly Ile Thr Arg Asp Ser Ile 
                165                 170                 175     


Met Asn Tyr Phe Arg Thr Glu Ser Glu Gly Arg Ser Pro Asn His Ile 
            180                 185                 190         


Val Val Leu Cys Arg Gly Arg Ala Phe Val Phe Asp Val Ile His Glu 
        195                 200                 205             


Gly Cys Leu Val Thr Pro Pro Glu Leu Leu Arg Gln Leu Thr Tyr Ile 
    210                 215                 220                 


His Lys Lys Cys His Ser Glu Pro Asp Gly Pro Gly Ile Ala Ala Leu 
225                 230                 235                 240 


Thr Ser Glu Glu Arg Thr Arg Trp Ala Lys Ala Arg Glu Tyr Leu Ile 
                245                 250                 255     


Gly Leu Asp Pro Glu Asn Leu Ala Leu Leu Glu Lys Ile Gln Ser Ser 
            260                 265                 270         


Leu Leu Val Tyr Ser Met Glu Asp Ser Ser Pro His Val Thr Pro Glu 
        275                 280                 285             


Asp Tyr Ser Glu Ile Ile Ala Ala Ile Leu Ile Gly Asp Pro Thr Val 
    290                 295                 300                 


Arg Trp Gly Asp Lys Ser Tyr Asn Leu Ile Ser Phe Ser Asn Gly Val 
305                 310                 315                 320 


Phe Gly Cys Asn Cys Asp His Ala Pro Phe Asp Ala Met Ile Met Val 
                325                 330                 335     


Asn Ile Ser Tyr Tyr Val Asp Glu Lys Ile Phe Gln Asn Glu Gly Arg 
            340                 345                 350         


Trp Lys Gly Ser Glu Lys Val Arg Asp Ile Pro Leu Pro Glu Glu Leu 
        355                 360                 365             


Ile Phe Ile Val Asp Glu Lys Val Leu Asn Asp Ile Asn Gln Ala Lys 
    370                 375                 380                 


Ala Gln Tyr Leu Arg Glu Ala Ser Asp Leu Gln Ile Ala Ala Tyr Ala 
385                 390                 395                 400 


Phe Thr Ser Phe Gly Lys Lys Leu Thr Lys Asn Lys Met Leu His Pro 
                405                 410                 415     


Asp Thr Phe Ile Gln Leu Ala Leu Gln Leu Ala Tyr Tyr Arg Leu His 
            420                 425                 430         


Gly His Pro Gly Cys Cys Tyr Glu Thr Ala Met Thr Arg His Phe Tyr 
        435                 440                 445             


His Gly Arg Thr Glu Thr Met Arg Ser Cys Thr Val Glu Ala Val Arg 
    450                 455                 460                 


Trp Cys Gln Ser Met Gln Asp Pro Ser Val Asn Leu Arg Glu Arg Gln 
465                 470                 475                 480 


Gln Lys Met Leu Gln Ala Phe Ala Lys His Asn Lys Met Met Lys Asp 
                485                 490                 495     


Cys Ser Ala Gly Lys Gly Phe Asp Arg His Leu Leu Gly Leu Leu Leu 
            500                 505                 510         


Ile Ala Lys Glu Glu Gly Leu Pro Val Pro Glu Leu Phe Thr Asp Pro 
        515                 520                 525             


Leu Phe Ser Lys Ser Gly Gly Gly Gly Asn Phe Val Leu Ser Thr Ser 
    530                 535                 540                 


Leu Val Gly Tyr Leu Arg Val Gln Gly Val Val Val Pro Met Val His 
545                 550                 555                 560 


Asn Gly Tyr Gly Phe Phe Tyr His Ile Arg Asp Asp Arg Phe Val Val 
                565                 570                 575     


Ala Cys Ser Ala Trp Lys Ser Cys Pro Glu Thr Asp Ala Glu Lys Leu 
            580                 585                 590         


Val Gln Leu Thr Phe Cys Ala Phe His Asp Met Ile Gln Leu Met Asn 
        595                 600                 605             


Ser Thr His Leu 
    610         


<210> 5549
<211> 590
<212> PRT
<213> Homo sapiens

<400> 5549
Met Ser Asp Ser Pro Ala Gly Ser Asn Pro Arg Thr Pro Glu Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Gly Gly Gly Lys Arg Pro Ala Val Pro Ala Ala 
            20                  25                  30          


Val Ser Leu Leu Pro Pro Ala Asp Pro Leu Arg Gln Ala Asn Arg Leu 
        35                  40                  45              


Pro Ile Arg Val Leu Lys Met Leu Ser Ala His Thr Gly His Leu Leu 
    50                  55                  60                  


His Pro Glu Tyr Leu Gln Pro Leu Ser Ser Thr Pro Val Ser Pro Ile 
65                  70                  75                  80  


Glu Leu Asp Ala Lys Lys Ser Pro Leu Ala Leu Leu Ala Gln Thr Cys 
                85                  90                  95      


Ser Gln Ile Gly Lys Pro Asp Pro Pro Pro Ser Ser Lys Leu Asn Ser 
            100                 105                 110         


Val Ala Ala Ala Ala Asn Gly Leu Gly Ala Glu Lys Asp Pro Gly Arg 
        115                 120                 125             


Ser Ala Pro Gly Ala Ala Ser Ala Ala Ala Ala Leu Lys Gln Leu Gly 
    130                 135                 140                 


Asp Ser Pro Ala Glu Asp Lys Ser Ser Phe Lys Pro Tyr Ser Lys Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Asp Ser Arg Lys Asp Ser Gly Ser Ser Ser Val Ser 
                165                 170                 175     


Ser Thr Ser Ser Ser Ser Ser Ser Ser Pro Gly Asp Lys Ala Gly Phe 
            180                 185                 190         


Arg Val Pro Ser Ala Ala Cys Pro Pro Phe Pro Pro His Gly Ala Pro 
        195                 200                 205             


Val Ser Ala Ser Ser Ser Ser Ser Ser Pro Gly Gly Ser Arg Gly Gly 
    210                 215                 220                 


Ser Pro His His Ser Asp Cys Lys Asn Gly Gly Gly Val Gly Gly Gly 
225                 230                 235                 240 


Glu Leu Asp Lys Lys Asp Gln Glu Pro Lys Pro Ser Pro Glu Pro Ala 
                245                 250                 255     


Ala Val Ser Arg Gly Gly Gly Gly Glu Pro Gly Ala His Gly Gly Ala 
            260                 265                 270         


Glu Ser Gly Ala Ser Gly Arg Lys Ser Glu Pro Pro Ser Ala Leu Val 
        275                 280                 285             


Gly Ala Gly His Val Ala Pro Val Ser Pro Tyr Lys Pro Gly His Ser 
    290                 295                 300                 


Val Phe Pro Leu Pro Pro Ser Ser Ile Gly Tyr His Gly Ser Ile Val 
305                 310                 315                 320 


Gly Ala Tyr Ala Gly Tyr Pro Ser Gln Phe Val Pro Gly Leu Asp Pro 
                325                 330                 335     


Ser Lys Ser Gly Leu Val Gly Gly Gln Leu Ser Gly Gly Leu Gly Leu 
            340                 345                 350         


Pro Pro Gly Lys Pro Pro Ser Ser Ser Pro Leu Thr Gly Ala Ser Pro 
        355                 360                 365             


Pro Ser Phe Leu Gln Gly Leu Cys Arg Asp Pro Tyr Cys Leu Gly Gly 
    370                 375                 380                 


Tyr His Gly Ala Ser His Leu Gly Gly Ser Ser Cys Ser Thr Cys Ser 
385                 390                 395                 400 


Ala His Asp Pro Ala Gly Pro Ser Leu Lys Ala Gly Gly Tyr Pro Leu 
                405                 410                 415     


Val Tyr Pro Gly His Pro Leu Gln Pro Ala Ala Leu Ser Ser Ser Ala 
            420                 425                 430         


Ala Gln Ala Ala Leu Pro Gly His Pro Leu Tyr Thr Tyr Gly Phe Met 
        435                 440                 445             


Leu Gln Asn Glu Pro Leu Pro His Ser Cys Asn Trp Val Ala Ala Ser 
    450                 455                 460                 


Gly Pro Cys Asp Lys Arg Phe Ala Thr Ser Glu Glu Leu Leu Ser His 
465                 470                 475                 480 


Leu Arg Thr His Thr Ala Leu Pro Gly Ala Glu Lys Leu Leu Ala Ala 
                485                 490                 495     


Tyr Pro Gly Ala Ser Gly Leu Gly Ser Ala Ala Ala Ala Ala Ala Ala 
            500                 505                 510         


Ala Ala Ser Cys His Leu His Leu Pro Pro Pro Ala Ala Pro Gly Ser 
        515                 520                 525             


Pro Gly Ser Leu Ser Leu Arg Asn Pro His Thr Leu Gly Leu Ser Arg 
    530                 535                 540                 


Tyr His Pro Tyr Gly Lys Ser His Leu Ser Thr Ala Gly Gly Leu Ala 
545                 550                 555                 560 


Val Pro Ser Leu Pro Thr Ala Gly Pro Tyr Tyr Ser Pro Tyr Ala Leu 
                565                 570                 575     


Tyr Gly Gln Arg Leu Ala Ser Ala Ser Ala Leu Gly Tyr Gln 
            580                 585                 590 


<210> 5550
<211> 339
<212> PRT
<213> Homo sapiens

<400> 5550
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr Ile 
        115                 120                 125             


Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe Tyr 
    130                 135                 140                 


Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp Gln 
145                 150                 155                 160 


Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg Glu 
                165                 170                 175     


Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn Tyr 
        195                 200                 205             


Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu Lys 
    210                 215                 220                 


Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys Trp 
225                 230                 235                 240 


Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile 
                245                 250                 255     


Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His Cys 
            260                 265                 270         


Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val Val 
        275                 280                 285             


Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile Val 
    290                 295                 300                 


Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln 
305                 310                 315                 320 


Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu 
                325                 330                 335     


Thr Leu Asp 
            


<210> 5551
<211> 638
<212> PRT
<213> Homo sapiens

<400> 5551
Met Ser Ala Leu Ala Gly Glu Asp Val Trp Arg Cys Pro Gly Cys Gly 
1               5                   10                  15      


Asp His Ile Ala Pro Ser Gln Ile Trp Tyr Arg Thr Val Asn Glu Thr 
            20                  25                  30          


Trp His Gly Ser Cys Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr 
        35                  40                  45              


Asn Trp Tyr Tyr Glu Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr 
    50                  55                  60                  


Trp Gly Lys Phe Gly Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr 
65                  70                  75                  80  


Gly Pro Phe Met Val Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe 
                85                  90                  95      


Ala Cys Met Ser Cys Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala 
            100                 105                 110         


Leu Val Gln His Ala Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val 
        115                 120                 125             


Val Leu Ala Pro Met Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu 
    130                 135                 140                 


Gln Leu Pro Tyr Ser Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu 
145                 150                 155                 160 


Gly Arg Arg Gly Phe Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr 
                165                 170                 175     


Ala Thr Thr Val Gln Val Lys Glu Val Asn Arg Met His Ile Ser Pro 
            180                 185                 190         


Asn Asn Arg Asn Ala Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn 
        195                 200                 205             


Gly Thr Pro Val Arg Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile 
    210                 215                 220                 


Ser Gln Thr Ser Gln Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val 
225                 230                 235                 240 


Ser Gln Arg Leu Asp Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His 
                245                 250                 255     


Met Gln Asn Ala Gly His Pro His Ala Leu Ser Thr Leu Asp Thr Lys 
            260                 265                 270         


Glu Asn Leu Glu Gly Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn 
        275                 280                 285             


Ser Ile Ser Lys Ser Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu 
    290                 295                 300                 


Phe Ser Arg Asp Ile Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser 
305                 310                 315                 320 


Tyr Ser Gln Gln Ile Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val 
                325                 330                 335     


Leu Gly Lys Gly Phe Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala 
            340                 345                 350         


Thr Gly Lys Val Met Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu 
        355                 360                 365             


Thr Gln Lys Thr Phe Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp 
    370                 375                 380                 


His Pro Asn Val Leu Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys 
385                 390                 395                 400 


Leu Asn Leu Leu Thr Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe 
                405                 410                 415     


Leu Arg Ser Met Asp Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala 
            420                 425                 430         


Lys Gly Ile Ala Ser Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile 
        435                 440                 445             


His Arg Asp Leu Asn Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr 
    450                 455                 460                 


Val Val Val Ala Asp Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Ala Pro Met Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg 
                485                 490                 495     


Lys Asn Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp 
            500                 505                 510         


Met Ala Pro Glu Met Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp 
        515                 520                 525             


Ile Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr 
    530                 535                 540                 


Ala Asp Pro Asp Cys Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val 
545                 550                 555                 560 


Lys Leu Phe Trp Glu Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe 
                565                 570                 575     


Phe Pro Leu Ala Ala Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Pro 
            580                 585                 590         


Ala Phe Ser Lys Leu Glu Asp Ser Phe Glu Ala Leu Ser Leu Tyr Leu 
        595                 600                 605             


Gly Glu Leu Gly Ile Pro Leu Pro Ala Glu Leu Glu Glu Leu Asp His 
    610                 615                 620                 


Thr Val Ser Met Gln Tyr Gly Leu Thr Arg Asp Ser Pro Pro 
625                 630                 635             


<210> 5552
<211> 201
<212> PRT
<213> Homo sapiens

<400> 5552
Met Ala Ala Ala Lys Asp Thr His Glu Asp His Asp Thr Ser Thr Glu 
1               5                   10                  15      


Asn Thr Asp Glu Ser Asn His Asp Pro Gln Phe Glu Pro Ile Val Ser 
            20                  25                  30          


Leu Pro Glu Gln Glu Ile Lys Thr Leu Glu Glu Asp Glu Glu Glu Leu 
        35                  40                  45              


Phe Lys Met Arg Ala Lys Leu Phe Arg Phe Ala Ser Glu Asn Asp Leu 
    50                  55                  60                  


Pro Glu Trp Lys Glu Arg Gly Thr Gly Asp Val Lys Leu Leu Lys His 
65                  70                  75                  80  


Lys Glu Lys Gly Ala Ile Arg Leu Leu Met Arg Arg Asp Lys Thr Leu 
                85                  90                  95      


Lys Ile Cys Ala Asn His Tyr Ile Thr Pro Met Met Glu Leu Lys Pro 
            100                 105                 110         


Asn Ala Gly Ser Asp Arg Ala Trp Val Trp Asn Thr His Ala Asp Phe 
        115                 120                 125             


Ala Asp Glu Cys Pro Lys Pro Glu Leu Leu Ala Ile Arg Phe Leu Asn 
    130                 135                 140                 


Ala Glu Asn Ala Gln Lys Phe Lys Thr Lys Phe Glu Glu Cys Arg Lys 
145                 150                 155                 160 


Glu Ile Glu Glu Arg Glu Lys Lys Ala Gly Ser Gly Lys Asn Asp His 
                165                 170                 175     


Ala Glu Lys Val Ala Glu Lys Leu Glu Ala Leu Ser Val Lys Glu Glu 
            180                 185                 190         


Thr Lys Glu Asp Ala Glu Glu Lys Gln 
        195                 200     


<210> 5553
<211> 717
<212> PRT
<213> Homo sapiens

<400> 5553
Met Ala Ala Asp Lys Pro Ala Asp Gln Gly Ala Glu Lys His Glu Gly 
1               5                   10                  15      


Thr Gly Gln Ser Ser Gly Ile Thr Asp Gln Glu Lys Glu Leu Ser Thr 
            20                  25                  30          


Asn Ala Phe Gln Ala Phe Thr Ser Gly Asn Tyr Asp Ala Cys Leu Gln 
        35                  40                  45              


His Leu Ala Cys Leu Gln Asp Ile Asn Lys Asp Asp Tyr Lys Ile Ile 
    50                  55                  60                  


Leu Asn Thr Ala Val Ala Glu Phe Phe Lys Ser Asn Gln Thr Thr Thr 
65                  70                  75                  80  


Asp Asn Leu Arg Gln Thr Leu Asn Gln Leu Lys Asn Gln Val His Ser 
                85                  90                  95      


Ala Val Glu Glu Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu 
            100                 105                 110         


Tyr Tyr Asn Gln Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Thr Glu 
        115                 120                 125             


Ala Ile Ser Val Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu 
    130                 135                 140                 


Glu Lys Phe Ala Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile 
145                 150                 155                 160 


Leu Thr Tyr Gln Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu 
                165                 170                 175     


Lys Met Ile Ser Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Thr 
            180                 185                 190         


Gly Asn Asn Asn Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly 
        195                 200                 205             


Ala Leu Ile Glu Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg 
    210                 215                 220                 


Ala Tyr Ile Gln Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys 
225                 230                 235                 240 


Ser Val Met Asn Thr Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys 
                245                 250                 255     


Ser Asn Phe Glu Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu 
            260                 265                 270         


Leu Asn Ser Ser Asn Ile Ala Glu His Pro Gly Phe Met Lys Thr Gly 
        275                 280                 285             


Glu Cys Leu Arg Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe 
    290                 295                 300                 


Ala Met Ser Lys His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu 
305                 310                 315                 320 


Gln Glu Asn Asp Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Thr Asp 
                325                 330                 335     


Pro Gly Lys Lys Phe Ser Gly Arg Pro Met Cys Thr Leu Leu Thr Asn 
            340                 345                 350         


Lys Arg Tyr Glu Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile 
        355                 360                 365             


Gly Arg Pro Leu Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val 
    370                 375                 380                 


Tyr His Ala Asn Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile 
385                 390                 395                 400 


Ala Ala Asn Lys Gly Thr Ser Glu Gln Glu Thr Lys Gly Leu Pro Ser 
                405                 410                 415     


Lys Lys Gly Ile Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys 
            420                 425                 430         


Ile Val Leu Ala Ser Gln Ser Ile Gln Asn Thr Val Tyr Asn Asp Gly 
        435                 440                 445             


Gln Ser Ser Ala Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys 
    450                 455                 460                 


Leu Arg Asn Ala Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys 
465                 470                 475                 480 


Gln Glu Asn Gly Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Thr Glu 
                485                 490                 495     


Ser Ser Glu Ser Ser Glu Thr Cys Arg Cys Ser Ile Leu Ala Cys Ser 
            500                 505                 510         


Ala Tyr Val Ala Leu Ala Leu Gly Asp Asn Leu Met Ala Leu Asn His 
        515                 520                 525             


Ala Asp Lys Leu Leu Gln Gln Pro Lys Leu Ser Gly Ser Leu Lys Phe 
    530                 535                 540                 


Leu Gly His Leu Tyr Ala Ala Glu Ala Leu Ile Ser Leu Asp Arg Ile 
545                 550                 555                 560 


Ser Asp Ala Ile Thr His Leu Asn Pro Glu Asn Val Thr Asp Val Ser 
                565                 570                 575     


Leu Gly Ile Ser Ser Asn Glu Gln Asp Gln Gly Ser Asp Lys Gly Glu 
            580                 585                 590         


Asn Glu Ala Met Glu Ser Ser Gly Lys Arg Ala Pro Gln Cys Tyr Pro 
        595                 600                 605             


Ser Ser Val Asn Ser Ala Arg Thr Val Met Leu Phe Asn Leu Gly Ser 
    610                 615                 620                 


Ala Tyr Cys Leu Arg Ser Glu Tyr Asp Lys Ala Arg Lys Cys Leu His 
625                 630                 635                 640 


Gln Ala Ala Ser Met Ile His Pro Lys Glu Val Pro Pro Glu Ala Ile 
                645                 650                 655     


Leu Leu Ala Val Tyr Leu Glu Leu Gln Asn Gly Asn Thr Gln Leu Ala 
            660                 665                 670         


Leu Gln Ile Ile Lys Arg Asn Gln Leu Leu Pro Ala Val Lys Thr His 
        675                 680                 685             


Ser Glu Val Arg Lys Lys Pro Val Phe Gln Pro Val His Pro Ile Gln 
    690                 695                 700                 


Pro Ile Gln Met Pro Ala Phe Thr Thr Val Gln Arg Lys 
705                 710                 715         


<210> 5554
<211> 495
<212> PRT
<213> Homo sapiens

<400> 5554
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Thr Met Arg Val Asn Asp Leu Val Gly Thr 
225                 230                 235                 240 


Ser Met Thr Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Thr Asn Thr Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Ser Leu Glu Ser Val Ser Ala Thr Cys Lys Gln 
305                 310                 315                 320 


Leu Ser Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu 
                325                 330                 335     


Ala His Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln 
            340                 345                 350         


Ile Leu Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys 
        355                 360                 365             


Met Glu Ile Ser His Leu Thr Gln Glu Leu His Gln Arg Asp Ile Thr 
    370                 375                 380                 


Ile Ala Ser Thr Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg 
385                 390                 395                 400 


Ala Glu Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile 
                405                 410                 415     


Leu Asp Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu 
            420                 425                 430         


Met Val Met Lys Leu Glu Leu Gly Leu His Glu Cys Ser Leu Pro Val 
        435                 440                 445             


Ser Pro Leu Gly Ser Ile Ala Thr Arg Phe Leu Glu Glu Glu Glu Leu 
    450                 455                 460                 


Arg Ser His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu 
465                 470                 475                 480 


Lys Arg Glu Ser Glu Lys Thr Val Arg Gln Phe Thr Ala Leu Lys 
                485                 490                 495 


<210> 5555
<211> 653
<212> PRT
<213> Homo sapiens

<400> 5555
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Arg Asp 
            260                 265                 270         


Asp Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Val Ser Ala 
        275                 280                 285             


Phe Val Lys Leu Ala Gln Ser Glu Tyr Gln Leu Leu Ala Asp Ile Ile 
    290                 295                 300                 


Pro Glu His His Gln Lys Lys Thr Phe Asp Ser Leu Ile Gln Asp Ala 
305                 310                 315                 320 


Leu Asp Gly Leu Met Leu Glu Gly Glu Asn Ile Val Ser Ala Ala Arg 
                325                 330                 335     


Lys Ala Ile Val Arg His Asp Phe Ser Thr Val Leu Thr Val Phe Pro 
            340                 345                 350         


Ile Leu Arg His Leu Lys Gln Thr Lys Pro Glu Phe Asp Gln Val Leu 
        355                 360                 365             


Gln Gly Thr Ala Ala Ser Thr Lys Asn Lys Leu Pro Gly Leu Ile Thr 
    370                 375                 380                 


Ser Met Glu Thr Ile Gly Ala Lys Ala Leu Glu Asp Phe Ala Asp Asn 
385                 390                 395                 400 


Ile Lys Asn Asp Pro Asp Lys Glu Tyr Asn Met Pro Lys Asp Gly Thr 
                405                 410                 415     


Val His Glu Leu Thr Ser Asn Ala Ile Leu Phe Leu Gln Gln Leu Leu 
            420                 425                 430         


Asp Phe Gln Glu Thr Ala Gly Ala Met Leu Ala Ser Gln Glu Thr Ser 
        435                 440                 445             


Ser Ser Ala Thr Ser Tyr Ser Ser Glu Phe Ser Lys Arg Leu Leu Ser 
    450                 455                 460                 


Thr Tyr Ile Cys Lys Val Leu Gly Asn Leu Gln Leu Asn Leu Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser Ala Ile Phe Leu His 
                485                 490                 495     


Asn Asn Tyr Asn Tyr Ile Leu Lys Ser Leu Glu Lys Ser Glu Leu Ile 
            500                 505                 510         


Gln Leu Val Ala Val Thr Gln Lys Thr Ala Glu Arg Ser Tyr Arg Glu 
        515                 520                 525             


His Ile Glu Gln Gln Ile Gln Thr Tyr Gln Arg Ser Trp Leu Lys Val 
    530                 535                 540                 


Thr Asp Tyr Ile Ala Glu Lys Asn Leu Pro Val Phe Gln Pro Gly Val 
545                 550                 555                 560 


Lys Leu Arg Asp Lys Glu Arg Gln Ile Ile Lys Glu Arg Phe Lys Gly 
                565                 570                 575     


Phe Asn Asp Gly Leu Glu Glu Leu Cys Lys Ile Gln Lys Ala Trp Ala 
            580                 585                 590         


Ile Pro Asp Thr Glu Gln Arg Asp Arg Ile Arg Gln Ala Gln Lys Thr 
        595                 600                 605             


Ile Val Lys Glu Thr Tyr Gly Ala Phe Leu Gln Lys Phe Gly Ser Val 
    610                 615                 620                 


Pro Phe Thr Lys Asn Pro Glu Lys Tyr Ile Lys Tyr Gly Val Glu Gln 
625                 630                 635                 640 


Val Gly Asp Met Ile Asp Arg Leu Phe Asp Thr Ser Ala 
                645                 650             


<210> 5556
<211> 244
<212> PRT
<213> Homo sapiens

<400> 5556
Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210> 5557
<211> 1173
<212> PRT
<213> Homo sapiens

<400> 5557
Met Ala Val Glu Thr Leu Ser Pro Asp Trp Glu Phe Asp Arg Val Asp 
1               5                   10                  15      


Asp Gly Ser Gln Lys Ile His Ala Glu Val Gln Leu Lys Asn Tyr Gly 
            20                  25                  30          


Lys Phe Leu Glu Glu Tyr Thr Ser Gln Leu Arg Arg Ile Glu Asp Ala 
        35                  40                  45              


Leu Asp Asp Ser Ile Gly Asp Val Trp Asp Phe Asn Leu Asp Pro Ile 
    50                  55                  60                  


Ala Leu Lys Leu Leu Pro Tyr Glu Gln Ser Ser Leu Leu Glu Leu Ile 
65                  70                  75                  80  


Lys Thr Glu Asn Lys Val Leu Asn Lys Val Ile Thr Val Tyr Ala Ala 
                85                  90                  95      


Leu Cys Cys Glu Ile Lys Lys Leu Lys Tyr Glu Ala Glu Thr Lys Phe 
            100                 105                 110         


Tyr Asn Gly Leu Leu Phe Tyr Gly Glu Gly Ala Thr Asp Ala Ser Met 
        115                 120                 125             


Val Glu Gly Asp Cys Gln Ile Gln Met Gly Arg Phe Ile Ser Phe Leu 
    130                 135                 140                 


Gln Glu Leu Ser Cys Phe Val Thr Arg Cys Tyr Glu Val Val Met Asn 
145                 150                 155                 160 


Val Val His Gln Leu Ala Ala Leu Tyr Ile Ser Asn Lys Ile Ala Pro 
                165                 170                 175     


Lys Ile Ile Glu Thr Thr Gly Val His Phe Gln Thr Met Tyr Glu His 
            180                 185                 190         


Leu Gly Glu Leu Leu Thr Val Leu Leu Thr Leu Asp Glu Ile Ile Asp 
        195                 200                 205             


Asn His Ile Thr Leu Lys Asp His Trp Thr Met Tyr Lys Arg Leu Leu 
    210                 215                 220                 


Lys Ser Val His His Asn Pro Ser Lys Phe Gly Ile Gln Glu Glu Lys 
225                 230                 235                 240 


Leu Lys Pro Phe Glu Lys Phe Leu Leu Lys Leu Glu Gly Gln Leu Leu 
                245                 250                 255     


Asp Gly Met Ile Phe Gln Ala Cys Ile Glu Gln Gln Phe Asp Ser Leu 
            260                 265                 270         


Asn Gly Gly Val Ser Val Ser Lys Asn Ser Thr Phe Ala Glu Glu Phe 
        275                 280                 285             


Ala His Ser Ile Arg Ser Ile Phe Ala Asn Val Glu Ala Lys Leu Gly 
    290                 295                 300                 


Glu Pro Ser Glu Ile Asp Gln Arg Asp Lys Tyr Val Gly Ile Cys Gly 
305                 310                 315                 320 


Leu Phe Val Leu His Phe Gln Ile Phe Arg Thr Ile Asp Lys Lys Phe 
                325                 330                 335     


Tyr Lys Ser Leu Leu Asp Ile Cys Lys Lys Val Pro Ala Ile Thr Leu 
            340                 345                 350         


Thr Ala Asn Ile Ile Trp Phe Pro Asp Asn Phe Leu Ile Gln Lys Ile 
        355                 360                 365             


Pro Ala Ala Ala Lys Leu Leu Asp Arg Lys Ser Leu Gln Ala Ile Lys 
    370                 375                 380                 


Ile His Arg Asp Thr Phe Leu Gln Gln Lys Ala Gln Ser Leu Thr Lys 
385                 390                 395                 400 


Asp Val Gln Ser Tyr Tyr Val Phe Val Ser Ser Trp Met Met Lys Met 
                405                 410                 415     


Glu Ser Ile Leu Ser Lys Glu Gln Arg Met Asp Lys Phe Ala Glu Asp 
            420                 425                 430         


Leu Thr Asn Arg Cys Asn Val Phe Ile Gln Gly Phe Leu Tyr Ala Tyr 
        435                 440                 445             


Ser Ile Ser Thr Ile Ile Lys Thr Thr Met Asn Leu Tyr Met Ser Met 
    450                 455                 460                 


Gln Lys Pro Met Thr Lys Thr Ser Val Lys Ala Leu Cys Arg Leu Val 
465                 470                 475                 480 


Glu Leu Leu Lys Ala Ile Glu His Met Phe Tyr Arg Arg Ser Met Val 
                485                 490                 495     


Val Ala Asp Ser Val Ser His Ile Thr Gln His Leu Gln His Gln Ala 
            500                 505                 510         


Leu His Ser Ile Ser Val Ala Lys Lys Arg Val Ile Ser Asp Lys Lys 
        515                 520                 525             


Tyr Ser Glu Gln Arg Leu Asp Val Leu Ser Ala Leu Val Leu Ala Glu 
    530                 535                 540                 


Asn Thr Leu Asn Gly Pro Ser Thr Lys Gln Arg Arg Leu Ile Val Ser 
545                 550                 555                 560 


Leu Ala Leu Ser Val Gly Thr Gln Met Lys Thr Phe Lys Asp Glu Glu 
                565                 570                 575     


Leu Phe Pro Leu Gln Val Val Met Lys Lys Leu Asp Leu Ile Ser Glu 
            580                 585                 590         


Leu Arg Glu Arg Val Gln Thr Gln Cys Asp Cys Cys Phe Leu Tyr Trp 
        595                 600                 605             


His Arg Ala Val Phe Pro Ile Tyr Leu Asp Asp Val Tyr Glu Asn Ala 
    610                 615                 620                 


Val Asp Ala Ala Arg Leu His Tyr Met Phe Ser Ala Leu Arg Asp Cys 
625                 630                 635                 640 


Val Pro Ala Met Met His Ala Arg His Leu Glu Ser Tyr Glu Ile Leu 
                645                 650                 655     


Leu Asp Cys Tyr Asp Lys Glu Ile Met Glu Ile Leu Asn Glu His Leu 
            660                 665                 670         


Leu Asp Lys Leu Cys Lys Glu Ile Glu Lys Asp Leu Arg Leu Ser Val 
        675                 680                 685             


His Thr His Leu Lys Leu Asp Asp Arg Asn Pro Phe Lys Val Gly Met 
    690                 695                 700                 


Lys Asp Leu Ala Leu Phe Phe Ser Leu Asn Pro Ile Arg Phe Phe Asn 
705                 710                 715                 720 


Arg Phe Ile Asp Ile Arg Ala Tyr Val Thr His Tyr Leu Asp Lys Thr 
                725                 730                 735     


Phe Tyr Asn Leu Thr Thr Val Ala Leu His Asp Trp Ala Thr Tyr Ser 
            740                 745                 750         


Glu Met Arg Asn Leu Ala Thr Gln Arg Tyr Gly Leu Val Met Thr Glu 
        755                 760                 765             


Ala His Leu Pro Ser Gln Thr Leu Glu Gln Gly Leu Asp Val Leu Glu 
    770                 775                 780                 


Ile Met Arg Asn Ile His Ile Phe Val Ser Arg Tyr Leu Tyr Asn Leu 
785                 790                 795                 800 


Asn Asn Gln Ile Phe Ile Glu Arg Thr Ser Asn Asn Lys His Leu Asn 
                805                 810                 815     


Thr Ile Asn Ile Arg His Ile Ala Asn Ser Ile Arg Thr His Gly Thr 
            820                 825                 830         


Gly Ile Met Asn Thr Thr Val Asn Phe Thr Tyr Gln Phe Leu Lys Lys 
        835                 840                 845             


Lys Phe Tyr Ile Phe Ser Gln Phe Met Tyr Asp Glu His Ile Lys Ser 
    850                 855                 860                 


Arg Leu Ile Lys Asp Ile Arg Phe Phe Arg Glu Ile Lys Asp Gln Asn 
865                 870                 875                 880 


Asp His Lys Tyr Pro Phe Asp Arg Ala Glu Lys Phe Asn Arg Gly Ile 
                885                 890                 895     


Arg Lys Leu Gly Val Thr Pro Glu Gly Gln Ser Tyr Leu Asp Gln Phe 
            900                 905                 910         


Arg Gln Leu Ile Ser Gln Ile Gly Asn Ala Met Gly Tyr Val Arg Met 
        915                 920                 925             


Ile Arg Ser Gly Gly Leu His Cys Ser Ser Asn Ala Ile Arg Phe Val 
    930                 935                 940                 


Pro Asp Leu Glu Asp Ile Val Asn Phe Glu Glu Leu Val Lys Glu Glu 
945                 950                 955                 960 


Gly Leu Ala Glu Glu Thr Leu Lys Ala Ala Arg His Leu Asp Ser Val 
                965                 970                 975     


Leu Ser Asp His Thr Arg Asn Ser Ala Glu Gly Thr Glu Tyr Phe Lys 
            980                 985                 990         


Met Leu Val Asp Val Phe Ala Pro  Glu Phe Arg Arg Pro  Lys Asn Ile 
        995                 1000                 1005             


His Leu  Arg Asn Phe Tyr Ile  Ile Val Pro Pro Leu  Thr Leu Asn 
    1010                 1015                 1020             


Phe Val  Glu His Ser Ile Ser  Cys Lys Glu Lys Leu  Asn Lys Lys 
    1025                 1030                 1035             


Asn Lys  Ile Gly Ala Ala Phe  Thr Asp Asp Gly Phe  Ala Met Gly 
    1040                 1045                 1050             


Val Ala  Tyr Ile Leu Lys Leu  Leu Asp Gln Tyr Arg  Glu Phe Asp 
    1055                 1060                 1065             


Ser Leu  His Trp Phe Gln Ser  Val Arg Glu Lys Tyr  Leu Lys Glu 
    1070                 1075                 1080             


Ile Arg  Ala Val Ala Lys Gln  Gln Asn Val Gln Ser  Ala Ser Gln 
    1085                 1090                 1095             


Asp Glu  Lys Leu Leu Gln Thr  Met Asn Leu Thr Gln  Lys Arg Leu 
    1100                 1105                 1110             


Asp Val  Tyr Leu Gln Glu Phe  Glu Leu Leu Tyr Phe  Ser Leu Ser 
    1115                 1120                 1125             


Ser Ala  Arg Ile Phe Phe Arg  Ala Asp Lys Thr Ala  Ala Glu Glu 
    1130                 1135                 1140             


Asn Gln  Glu Lys Lys Glu Lys  Glu Glu Glu Thr Lys  Thr Ser Asn 
    1145                 1150                 1155             


Gly Asp  Leu Ser Asp Ser Thr  Val Ser Ala Asp Pro  Val Val Lys 
    1160                 1165                 1170             


<210> 5558
<211> 323
<212> PRT
<213> Homo sapiens

<400> 5558
Met Leu Arg Trp Thr Val His Leu Glu Gly Gly Pro Arg Arg Val Asn 
1               5                   10                  15      


His Ala Ala Val Ala Val Gly His Arg Val Tyr Ser Phe Gly Gly Tyr 
            20                  25                  30          


Cys Ser Gly Glu Asp Tyr Glu Thr Leu Arg Gln Ile Asp Val His Ile 
        35                  40                  45              


Phe Asn Ala Asp Thr His Lys Trp Phe Thr Pro Arg Val Ser Gly Thr 
    50                  55                  60                  


Val Pro Gly Ala Arg Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile 
65                  70                  75                  80  


Met Tyr Ile Phe Gly Gly Tyr Glu Gln Gln Ala Asp Cys Phe Ser Asn 
                85                  90                  95      


Asp Ile His Lys Leu Asp Thr Ser Thr Met Thr Trp Thr Leu Ile Cys 
            100                 105                 110         


Thr Lys Gly Ser Pro Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met 
        115                 120                 125             


Leu Gly Ser His Met Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly 
    130                 135                 140                 


Pro Phe His Ser Asn Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe 
145                 150                 155                 160 


Asp Thr Arg Thr Glu Ala Trp Leu Asp Cys Pro Pro Thr Pro Val Leu 
                165                 170                 175     


Pro Glu Gly Arg Arg Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu 
            180                 185                 190         


Tyr Ile Phe Gly Gly Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp 
        195                 200                 205             


Leu Trp Lys Phe Asn Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro 
    210                 215                 220                 


Lys Gly Lys Gly Pro Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val 
225                 230                 235                 240 


Gly Asp Lys Ile Val Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu 
                245                 250                 255     


Gly Leu Gly Asp Glu Phe Asp Leu Ile Asp His Ser Asp Leu His Ile 
            260                 265                 270         


Leu Asp Phe Ser Pro Ser Leu Lys Thr Leu Cys Lys Leu Ala Val Ile 
        275                 280                 285             


Gln Tyr Asn Leu Asp Gln Ser Cys Leu Pro His Asp Ile Arg Trp Glu 
    290                 295                 300                 


Leu Asn Ala Met Thr Thr Asn Ser Asn Ile Ser Arg Pro Ile Val Ser 
305                 310                 315                 320 


Ser His Gly 
            


<210> 5559
<211> 838
<212> PRT
<213> Homo sapiens

<400> 5559
Met Thr Gly Ala Glu Ile Glu Pro Ser Ala Gln Ala Lys Pro Glu Lys 
1               5                   10                  15      


Lys Ala Gly Glu Glu Val Ile Ala Gly Pro Glu Arg Glu Asn Asp Val 
            20                  25                  30          


Pro Leu Val Val Arg Pro Lys Val Arg Thr Gln Ala Thr Thr Gly Ala 
        35                  40                  45              


Arg Pro Lys Thr Glu Thr Lys Ser Val Pro Ala Ala Arg Pro Lys Thr 
    50                  55                  60                  


Glu Ala Gln Ala Met Ser Gly Ala Arg Pro Lys Thr Glu Val Gln Val 
65                  70                  75                  80  


Met Gly Gly Ala Arg Pro Lys Thr Glu Ala Gln Gly Ile Thr Gly Ala 
                85                  90                  95      


Arg Pro Lys Thr Asp Ala Arg Ala Val Gly Gly Ala Arg Ser Lys Thr 
            100                 105                 110         


Asp Ala Lys Ala Ile Pro Gly Ala Arg Pro Lys Asp Glu Ala Gln Ala 
        115                 120                 125             


Trp Ala Gln Ser Glu Phe Gly Thr Glu Ala Val Ser Gln Ala Glu Gly 
    130                 135                 140                 


Val Ser Gln Thr Asn Ala Val Ala Trp Pro Leu Ala Thr Ala Glu Ser 
145                 150                 155                 160 


Gly Ser Val Thr Lys Ser Lys Gly Leu Ser Met Asp Arg Glu Leu Val 
                165                 170                 175     


Asn Val Asp Ala Glu Thr Phe Pro Gly Thr Gln Gly Gln Lys Gly Ile 
            180                 185                 190         


Gln Pro Trp Phe Gly Pro Gly Glu Glu Thr Asn Met Gly Ser Trp Cys 
        195                 200                 205             


Tyr Ser Arg Pro Arg Ala Arg Glu Glu Ala Ser Asn Glu Ser Gly Phe 
    210                 215                 220                 


Trp Ser Ala Asp Glu Thr Ser Thr Ala Ser Ser Phe Trp Thr Gly Glu 
225                 230                 235                 240 


Glu Thr Ser Val Arg Ser Trp Pro Arg Glu Glu Ser Asn Thr Arg Ser 
                245                 250                 255     


Arg His Arg Ala Lys His Gln Thr Asn Pro Arg Ser Arg Pro Arg Ser 
            260                 265                 270         


Lys Gln Glu Ala Tyr Val Asp Ser Trp Ser Gly Ser Glu Asp Glu Ala 
        275                 280                 285             


Ser Asn Pro Phe Ser Phe Trp Val Gly Glu Asn Thr Asn Asn Leu Phe 
    290                 295                 300                 


Arg Pro Arg Val Arg Glu Glu Ala Asn Ile Arg Ser Lys Leu Arg Thr 
305                 310                 315                 320 


Asn Arg Glu Asp Cys Phe Glu Ser Glu Ser Glu Asp Glu Phe Tyr Lys 
                325                 330                 335     


Gln Ser Trp Val Leu Pro Gly Glu Glu Ala Asn Ser Arg Phe Arg His 
            340                 345                 350         


Arg Asp Lys Glu Asp Pro Asn Thr Ala Leu Lys Leu Arg Ala Gln Lys 
        355                 360                 365             


Asp Val Asp Ser Asp Arg Val Lys Gln Glu Pro Arg Phe Glu Glu Glu 
    370                 375                 380                 


Val Ile Ile Gly Ser Trp Phe Trp Ala Glu Lys Glu Ala Ser Leu Glu 
385                 390                 395                 400 


Gly Gly Ala Ser Ala Ile Cys Glu Ser Glu Pro Gly Thr Glu Glu Gly 
                405                 410                 415     


Ala Ile Gly Gly Ser Ala Tyr Trp Ala Glu Glu Lys Ser Ser Leu Gly 
            420                 425                 430         


Ala Val Ala Arg Glu Glu Ala Lys Pro Glu Ser Glu Glu Glu Ala Ile 
        435                 440                 445             


Phe Gly Ser Trp Phe Trp Asp Arg Asp Glu Ala Cys Phe Asp Leu Asn 
    450                 455                 460                 


Pro Cys Pro Val Tyr Lys Val Ser Asp Arg Phe Arg Asp Ala Ala Glu 
465                 470                 475                 480 


Glu Leu Asn Ala Ser Ser Arg Pro Gln Thr Trp Asp Glu Val Thr Val 
                485                 490                 495     


Glu Phe Lys Pro Gly Leu Phe His Gly Val Gly Phe Arg Ser Thr Ser 
            500                 505                 510         


Pro Phe Gly Ile Pro Glu Glu Ala Ser Glu Met Leu Glu Ala Lys Pro 
        515                 520                 525             


Lys Asn Leu Glu Leu Ser Pro Glu Gly Glu Glu Gln Glu Ser Leu Leu 
    530                 535                 540                 


Gln Pro Asp Gln Pro Ser Pro Glu Phe Thr Phe Gln Tyr Asp Pro Ser 
545                 550                 555                 560 


Tyr Arg Ser Val Arg Glu Ile Arg Glu His Leu Arg Ala Arg Glu Ser 
                565                 570                 575     


Ala Glu Ser Glu Ser Trp Ser Cys Ser Cys Ile Gln Cys Glu Leu Lys 
            580                 585                 590         


Ile Gly Ser Glu Glu Phe Glu Glu Phe Leu Leu Leu Met Asp Lys Ile 
        595                 600                 605             


Arg Asp Pro Phe Ile His Glu Ile Ser Lys Ile Ala Met Gly Met Arg 
    610                 615                 620                 


Ser Ala Ser Gln Phe Thr Arg Asp Phe Ile Arg Asp Ser Gly Val Val 
625                 630                 635                 640 


Ser Leu Ile Glu Thr Leu Leu Asn Tyr Pro Ser Ser Arg Val Arg Thr 
                645                 650                 655     


Ser Phe Leu Glu Asn Met Ile His Met Ala Pro Pro Tyr Pro Asn Leu 
            660                 665                 670         


Asn Met Ile Glu Thr Phe Ile Cys Gln Val Cys Glu Glu Thr Leu Ala 
        675                 680                 685             


His Ser Val Asp Ser Leu Glu Gln Leu Thr Gly Ile Arg Met Leu Arg 
    690                 695                 700                 


His Leu Thr Met Thr Ile Asp Tyr His Thr Leu Ile Ala Asn Tyr Met 
705                 710                 715                 720 


Ser Gly Phe Leu Ser Leu Leu Thr Thr Ala Asn Ala Arg Thr Lys Phe 
                725                 730                 735     


His Val Leu Lys Met Leu Leu Asn Leu Ser Glu Asn Pro Ala Val Ala 
            740                 745                 750         


Lys Lys Leu Phe Ser Ala Lys Ala Leu Ser Ile Phe Val Gly Leu Phe 
        755                 760                 765             


Asn Ile Glu Glu Thr Asn Asp Asn Ile Gln Ile Val Ile Lys Met Phe 
    770                 775                 780                 


Gln Asn Ile Ser Asn Ile Ile Lys Ser Gly Lys Met Ser Leu Ile Asp 
785                 790                 795                 800 


Asp Asp Phe Ser Leu Glu Pro Leu Ile Ser Ala Phe Arg Glu Phe Glu 
                805                 810                 815     


Glu Leu Ala Lys Gln Leu Gln Ala Gln Ile Asp Asn Gln Asn Asp Pro 
            820                 825                 830         


Glu Val Gly Gln Gln Ser 
        835             


<210> 5560
<211> 882
<212> PRT
<213> Homo sapiens

<400> 5560
Met Pro Gly Arg Ala Arg Thr Arg Ala Arg Gly Arg Ala Arg Arg Arg 
1               5                   10                  15      


Glu Ser Tyr Gln Gln Glu Ala Pro Gly Gly Pro Arg Ala Pro Gly Ser 
            20                  25                  30          


Ala Thr Thr Gln Glu Pro Pro Gln Leu Gln Ser Thr Pro Arg Pro Leu 
        35                  40                  45              


Gln Glu Glu Val Pro Val Val Arg Pro Leu Gln Pro Arg Ala Ala Arg 
    50                  55                  60                  


Gly Gly Ala Gly Gly Gly Ala Gln Ser Gln Gly Val Lys Glu Pro Gly 
65                  70                  75                  80  


Pro Glu Ala Gly Leu His Thr Ala Pro Leu Gln Glu Arg Arg Ile Gly 
                85                  90                  95      


Gly Val Phe Gln Asp Leu Val Val Asn Thr Arg Gln Asp Met Lys His 
            100                 105                 110         


Val Lys Asp Ser Lys Thr Gly Ser Glu Gly Thr Val Val Gln Leu Leu 
        115                 120                 125             


Ala Asn His Phe Arg Val Ile Ser Arg Pro Gln Trp Val Ala Tyr Lys 
    130                 135                 140                 


Tyr Asn Val Asp Tyr Lys Pro Asp Ile Glu Asp Gly Asn Leu Arg Thr 
145                 150                 155                 160 


Ile Leu Leu Asp Gln His Arg Arg Lys Phe Gly Glu Arg His Ile Phe 
                165                 170                 175     


Asp Gly Asn Ser Leu Leu Leu Ser Arg Pro Leu Lys Glu Arg Arg Val 
            180                 185                 190         


Glu Trp Leu Ser Thr Thr Lys Asp Lys Asn Ile Val Lys Ile Thr Val 
        195                 200                 205             


Glu Phe Ser Lys Glu Leu Thr Pro Thr Ser Pro Asp Cys Leu Arg Tyr 
    210                 215                 220                 


Tyr Asn Ile Leu Phe Arg Arg Thr Phe Lys Leu Leu Asp Phe Glu Gln 
225                 230                 235                 240 


Val Gly Arg Asn Tyr Tyr Thr Lys Lys Lys Ala Ile Gln Leu Tyr Arg 
                245                 250                 255     


His Gly Thr Ser Leu Glu Ile Trp Leu Gly Tyr Val Thr Ser Val Leu 
            260                 265                 270         


Gln Tyr Glu Asn Ser Ile Thr Leu Cys Ala Asp Val Ser His Lys Leu 
        275                 280                 285             


Leu Arg Ile Glu Thr Ala Tyr Asp Phe Ile Lys Arg Thr Ser Ala Gln 
    290                 295                 300                 


Ala Gln Thr Gly Asn Ile Arg Glu Glu Val Thr Asn Lys Leu Ile Gly 
305                 310                 315                 320 


Ser Ile Val Leu Thr Lys Tyr Asn Asn Lys Thr Tyr Arg Val Asp Asp 
                325                 330                 335     


Ile Asp Trp Lys Gln Asn Pro Glu Asp Thr Phe Asn Lys Ser Asp Gly 
            340                 345                 350         


Ser Lys Ile Thr Tyr Ile Asp Tyr Tyr Arg Gln Gln His Lys Glu Ile 
        355                 360                 365             


Val Thr Val Lys Lys Gln Pro Leu Leu Val Ser Gln Gly Arg Trp Lys 
    370                 375                 380                 


Lys Gly Leu Thr Gly Thr Gln Arg Glu Pro Ile Leu Leu Ile Pro Gln 
385                 390                 395                 400 


Leu Cys His Met Thr Gly Leu Thr Asp Glu Ile Cys Lys Asp Tyr Ser 
                405                 410                 415     


Ile Val Lys Glu Leu Ala Lys His Thr Arg Leu Ser Pro Arg Arg Arg 
            420                 425                 430         


His His Thr Leu Lys Glu Phe Ile Asn Thr Leu Gln Asp Asn Lys Lys 
        435                 440                 445             


Val Arg Glu Leu Leu Gln Leu Trp Asp Leu Lys Phe Asp Thr Asn Phe 
    450                 455                 460                 


Leu Ser Val Pro Gly Arg Val Leu Lys Asn Ala Asn Ile Val Gln Gly 
465                 470                 475                 480 


Arg Arg Met Val Lys Ala Asn Ser Gln Gly Asp Trp Ser Arg Glu Ile 
                485                 490                 495     


Arg Glu Leu Pro Leu Leu Asn Ala Met Pro Leu His Ser Trp Leu Ile 
            500                 505                 510         


Leu Tyr Ser Arg Ser Ser His Arg Glu Ala Met Ser Leu Lys Gly His 
        515                 520                 525             


Leu Gln Ser Val Thr Ala Pro Met Gly Ile Thr Met Lys Pro Ala Glu 
    530                 535                 540                 


Met Ile Glu Val Asp Gly Asp Ala Asn Ser Tyr Ile Asp Thr Leu Arg 
545                 550                 555                 560 


Lys Tyr Thr Arg Pro Thr Leu Gln Met Gly Met Ser Cys Leu Leu Val 
                565                 570                 575     


Phe Lys Val Ile Cys Ile Leu Pro Asn Asp Asp Lys Arg Arg Tyr Asp 
            580                 585                 590         


Ser Ile Lys Arg Tyr Leu Cys Thr Lys Cys Pro Ile Pro Ser Gln Cys 
        595                 600                 605             


Val Val Lys Lys Thr Leu Glu Lys Val Gln Ala Arg Thr Ile Val Thr 
    610                 615                 620                 


Lys Ile Ala Gln Gln Met Asn Cys Lys Met Gly Gly Ala Leu Trp Lys 
625                 630                 635                 640 


Val Glu Thr Asp Val Gln Arg Thr Met Phe Val Gly Ile Asp Cys Phe 
                645                 650                 655     


His Asp Ile Val Asn Arg Gln Lys Ser Ile Ala Gly Phe Val Ala Ser 
            660                 665                 670         


Thr Asn Ala Glu Leu Thr Lys Trp Tyr Ser Gln Cys Val Ile Gln Lys 
        675                 680                 685             


Thr Gly Glu Glu Leu Val Lys Glu Leu Glu Ile Cys Leu Lys Ala Ala 
    690                 695                 700                 


Leu Asp Val Trp Cys Lys Asn Glu Ser Ser Met Pro His Ser Val Ile 
705                 710                 715                 720 


Val Tyr Arg Asp Gly Val Gly Asp Gly Gln Leu Gln Ala Leu Leu Asp 
                725                 730                 735     


His Glu Ala Lys Lys Met Ser Thr Tyr Leu Lys Thr Ile Ser Pro Asn 
            740                 745                 750         


Asn Phe Thr Leu Ala Phe Ile Val Val Lys Lys Arg Ile Asn Thr Arg 
        755                 760                 765             


Phe Phe Leu Lys His Gly Ser Asn Phe Gln Asn Pro Pro Pro Gly Thr 
    770                 775                 780                 


Val Ile Asp Val Glu Leu Thr Arg Asn Glu Trp Tyr Asp Phe Phe Ile 
785                 790                 795                 800 


Val Ser Gln Ser Val Gln Asp Gly Thr Val Thr Pro Thr His Tyr Asn 
                805                 810                 815     


Val Ile Tyr Asp Thr Ile Gly Leu Ser Pro Asp Thr Val Gln Arg Leu 
            820                 825                 830         


Thr Tyr Cys Leu Cys His Met Tyr Tyr Asn Leu Pro Gly Ile Ile Arg 
        835                 840                 845             


Val Pro Ala Pro Cys His Tyr Ala His Lys Leu Ala Tyr Leu Val Gly 
    850                 855                 860                 


Gln Ser Ile His Gln Glu Pro Asn Arg Ser Leu Ser Thr Arg Leu Phe 
865                 870                 875                 880 


Tyr Leu 
        


<210> 5561
<211> 638
<212> PRT
<213> Homo sapiens

<400> 5561
Met Asn Arg Gln Val Cys Lys Lys Ser Phe Ser Gly Arg Ser Gln Gly 
1               5                   10                  15      


Phe Ser Gly Arg Ser Ala Val Val Ser Gly Ser Ser Arg Met Ser Cys 
            20                  25                  30          


Val Ala Arg Ser Gly Gly Ala Gly Gly Gly Ala Cys Gly Phe Arg Ser 
        35                  40                  45              


Gly Ala Gly Ser Phe Gly Ser Arg Ser Leu Tyr Asn Leu Gly Ser Asn 
    50                  55                  60                  


Lys Ser Ile Ser Ile Ser Val Ala Ala Gly Ser Ser Arg Ala Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Arg Ser Ser Cys Gly Phe Ala Gly Gly Tyr Gly Gly 
                85                  90                  95      


Gly Phe Gly Gly Ser Tyr Gly Gly Gly Phe Gly Gly Gly Arg Gly Val 
            100                 105                 110         


Gly Ser Gly Phe Gly Gly Ala Gly Gly Phe Gly Gly Ala Gly Gly Phe 
        115                 120                 125             


Gly Gly Pro Gly Val Phe Gly Gly Pro Gly Ser Phe Gly Gly Pro Gly 
    130                 135                 140                 


Gly Phe Gly Pro Gly Gly Phe Pro Gly Gly Ile Gln Glu Val Ile Val 
145                 150                 155                 160 


Asn Gln Ser Leu Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Gln Ile 
                165                 170                 175     


Gly Gln Val Lys Ala Gln Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn 
            180                 185                 190         


Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        195                 200                 205             


Lys Val Leu Glu Thr Lys Trp Glu Leu Leu Gln Gln Gln Thr Thr Gly 
    210                 215                 220                 


Ser Gly Pro Ser Ser Leu Glu Pro Cys Phe Glu Ser Tyr Ile Ser Phe 
225                 230                 235                 240 


Leu Cys Lys Gln Leu Asp Ser Leu Leu Gly Glu Arg Gly Asn Leu Glu 
                245                 250                 255     


Gly Glu Leu Lys Ser Met Gln Asp Leu Val Glu Asp Phe Lys Lys Lys 
            260                 265                 270         


Tyr Glu Asp Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val 
        275                 280                 285             


Gly Leu Lys Lys Asp Val Asp Ala Ala Phe Met Asn Lys Val Glu Leu 
    290                 295                 300                 


Gln Ala Lys Val Asp Ser Leu Thr Asp Glu Val Ser Phe Leu Arg Thr 
305                 310                 315                 320 


Leu Tyr Glu Met Glu Leu Ser Gln Met Gln Ser His Ala Ser Asp Thr 
                325                 330                 335     


Ser Val Val Leu Ser Met Asp Asn Asn Arg Cys Leu Asp Leu Gly Ser 
            340                 345                 350         


Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser 
        355                 360                 365             


Lys Ser Glu Ala Glu Ala Leu Tyr Gln Thr Lys Leu Gly Glu Leu Gln 
    370                 375                 380                 


Thr Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys Ser Glu 
385                 390                 395                 400 


Ile Met Glu Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile Glu 
                405                 410                 415     


Asn Val Lys Lys Gln Asn Ala Asn Leu Gln Thr Ala Ile Ala Glu Ala 
            420                 425                 430         


Glu Gln Arg Gly Glu Met Ala Leu Lys Asp Ala Asn Ala Lys Leu Gln 
        435                 440                 445             


Asp Leu Gln Thr Ala Leu Gln Lys Ala Lys Asp Asp Leu Ala Arg Leu 
    450                 455                 460                 


Leu Arg Asp Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val 
465                 470                 475                 480 


Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Met 
                485                 490                 495     


Ser Gly Glu Cys Gln Ser Ala Val Cys Ile Ser Val Val Ser Asn Val 
            500                 505                 510         


Thr Ser Thr Ser Gly Ser Ser Gly Ser Ser Arg Gly Val Phe Gly Gly 
        515                 520                 525             


Val Ser Gly Ser Gly Ser Gly Gly Tyr Lys Gly Gly Ser Ser Ser Ser 
    530                 535                 540                 


Ser Ser Ser Gly Tyr Gly Val Ser Gly Gly Ser Gly Ser Gly Tyr Gly 
545                 550                 555                 560 


Gly Val Ser Ser Gly Ser Thr Gly Gly Arg Gly Ser Ser Gly Ser Tyr 
                565                 570                 575     


Gln Ser Ser Ser Ser Gly Ser Arg Leu Gly Gly Ala Gly Ser Ile Ser 
            580                 585                 590         


Val Ser His Ser Gly Met Gly Ser Ser Ser Gly Ser Ile Gln Thr Ser 
        595                 600                 605             


Gly Gly Ser Gly Tyr Lys Ser Gly Gly Gly Gly Ser Thr Ser Ile Arg 
    610                 615                 620                 


Phe Ser Gln Thr Thr Ser Ser Ser Gln His Ser Ser Thr Lys 
625                 630                 635             


<210> 5562
<211> 359
<212> PRT
<213> Homo sapiens

<400> 5562
Met Ala Glu Pro Phe Leu Ser Glu Tyr Gln His Gln Pro Gln Thr Ser 
1               5                   10                  15      


Asn Cys Thr Gly Ala Ala Ala Val Gln Glu Glu Leu Asn Pro Glu Arg 
            20                  25                  30          


Pro Pro Gly Ala Glu Glu Arg Val Pro Glu Glu Asp Ser Arg Trp Gln 
        35                  40                  45              


Ser Arg Ala Phe Pro Gln Leu Gly Gly Arg Pro Gly Pro Glu Gly Glu 
    50                  55                  60                  


Gly Ser Leu Glu Ser Gln Pro Pro Pro Leu Gln Thr Gln Ala Cys Pro 
65                  70                  75                  80  


Glu Ser Ser Cys Leu Arg Glu Gly Glu Lys Gly Gln Asn Gly Asp Asp 
                85                  90                  95      


Ser Ser Ala Gly Gly Asp Phe Pro Pro Pro Ala Glu Val Glu Pro Thr 
            100                 105                 110         


Pro Glu Ala Glu Leu Leu Ala Gln Pro Cys His Asp Ser Glu Ala Ser 
        115                 120                 125             


Lys Leu Gly Ala Pro Ala Ala Gly Gly Glu Glu Glu Trp Gly Gln Gln 
    130                 135                 140                 


Gln Arg Gln Leu Gly Lys Lys Lys His Arg Arg Arg Pro Ser Lys Lys 
145                 150                 155                 160 


Lys Arg His Trp Lys Pro Tyr Tyr Lys Leu Thr Trp Glu Glu Lys Lys 
                165                 170                 175     


Lys Phe Asp Glu Lys Gln Ser Leu Arg Ala Ser Arg Ile Arg Ala Glu 
            180                 185                 190         


Met Phe Ala Lys Gly Gln Pro Val Ala Pro Tyr Asn Thr Thr Gln Phe 
        195                 200                 205             


Leu Met Asp Asp His Asp Gln Glu Glu Pro Asp Leu Lys Thr Gly Leu 
    210                 215                 220                 


Tyr Ser Lys Arg Ala Ala Ala Lys Ser Asp Asp Thr Ser Asp Asp Asp 
225                 230                 235                 240 


Phe Met Glu Glu Gly Gly Glu Glu Asp Gly Gly Ser Asp Gly Met Gly 
                245                 250                 255     


Gly Asp Gly Ser Glu Phe Leu Gln Arg Asp Phe Ser Glu Thr Tyr Glu 
            260                 265                 270         


Arg Tyr His Thr Glu Ser Leu Gln Asn Met Ser Lys Gln Glu Leu Ile 
        275                 280                 285             


Lys Glu Tyr Leu Glu Leu Glu Lys Cys Leu Ser Arg Met Glu Asp Glu 
    290                 295                 300                 


Asn Asn Arg Leu Arg Leu Glu Ser Lys Arg Leu Gly Gly Asp Asp Ala 
305                 310                 315                 320 


Arg Val Arg Glu Leu Glu Leu Glu Leu Asp Arg Leu Arg Ala Glu Asn 
                325                 330                 335     


Leu Gln Leu Leu Thr Glu Asn Glu Leu His Arg Gln Gln Glu Arg Ala 
            340                 345                 350         


Pro Leu Ser Lys Phe Gly Asp 
        355                 


<210> 5563
<211> 962
<212> PRT
<213> Homo sapiens

<400> 5563
Met Asp Glu Gln Ala Leu Leu Gly Leu Asn Pro Asn Ala Asp Ser Asp 
1               5                   10                  15      


Phe Arg Gln Arg Ala Leu Ala Tyr Phe Glu Gln Leu Lys Ile Ser Pro 
            20                  25                  30          


Asp Ala Trp Gln Val Cys Ala Glu Ala Leu Ala Gln Arg Thr Tyr Ser 
        35                  40                  45              


Asp Asp His Val Lys Phe Phe Cys Phe Gln Val Leu Glu His Gln Val 
    50                  55                  60                  


Lys Tyr Lys Tyr Ser Glu Leu Thr Thr Val Gln Gln Gln Leu Ile Arg 
65                  70                  75                  80  


Glu Thr Leu Ile Ser Trp Leu Gln Ala Gln Met Leu Asn Pro Gln Pro 
                85                  90                  95      


Glu Lys Thr Phe Ile Arg Asn Lys Ala Ala Gln Val Phe Ala Leu Leu 
            100                 105                 110         


Phe Val Thr Glu Tyr Leu Thr Lys Trp Pro Lys Phe Phe Phe Asp Ile 
        115                 120                 125             


Leu Ser Val Val Asp Leu Asn Pro Arg Gly Val Asp Leu Tyr Leu Arg 
    130                 135                 140                 


Ile Leu Met Ala Ile Asp Ser Glu Leu Val Asp Arg Asp Val Val His 
145                 150                 155                 160 


Thr Ser Glu Glu Ala Arg Arg Asn Thr Leu Ile Lys Asp Thr Met Arg 
                165                 170                 175     


Glu Gln Cys Ile Pro Asn Leu Val Glu Ser Trp Tyr Gln Ile Leu Gln 
            180                 185                 190         


Asn Tyr Gln Phe Thr Asn Ser Glu Val Thr Cys Gln Cys Leu Glu Val 
        195                 200                 205             


Val Gly Ala Tyr Val Ser Trp Ile Asp Leu Ser Leu Ile Ala Asn Asp 
    210                 215                 220                 


Arg Phe Ile Asn Met Leu Leu Gly His Met Ser Ile Glu Val Leu Arg 
225                 230                 235                 240 


Glu Glu Ala Cys Asp Cys Leu Phe Glu Val Val Asn Lys Gly Met Asp 
                245                 250                 255     


Pro Val Asp Lys Met Lys Leu Val Glu Ser Leu Cys Gln Val Leu Gln 
            260                 265                 270         


Ser Ala Gly Phe Phe Ser Ile Asp Gln Glu Glu Asp Val Asp Phe Leu 
        275                 280                 285             


Ala Arg Phe Ser Lys Leu Val Asn Gly Met Gly Gln Ser Leu Ile Val 
    290                 295                 300                 


Ser Trp Ser Lys Leu Ile Lys Asn Gly Asp Ile Lys Asn Ala Gln Glu 
305                 310                 315                 320 


Ala Leu Gln Ala Ile Glu Thr Lys Val Ala Leu Met Leu Gln Leu Leu 
                325                 330                 335     


Ile His Glu Asp Asp Asp Ile Ser Ser Asn Ile Ile Gly Phe Cys Tyr 
            340                 345                 350         


Asp Tyr Leu His Ile Leu Lys Gln Leu Thr Val Leu Ser Asp Gln Gln 
        355                 360                 365             


Lys Ala Asn Val Glu Ala Ile Met Leu Ala Val Met Lys Lys Leu Thr 
    370                 375                 380                 


Tyr Asp Glu Glu Tyr Asn Phe Glu Asn Glu Gly Glu Asp Glu Ala Met 
385                 390                 395                 400 


Phe Val Glu Tyr Arg Lys Gln Leu Lys Leu Leu Leu Asp Arg Leu Ala 
                405                 410                 415     


Gln Val Ser Pro Glu Leu Leu Leu Ala Ser Val Arg Arg Val Phe Ser 
            420                 425                 430         


Ser Thr Leu Gln Asn Trp Gln Thr Thr Arg Phe Met Glu Val Glu Val 
        435                 440                 445             


Ala Ile Arg Leu Leu Tyr Met Leu Ala Glu Ala Leu Pro Val Ser His 
    450                 455                 460                 


Gly Ala His Phe Ser Gly Asp Val Ser Lys Ala Ser Ala Leu Gln Asp 
465                 470                 475                 480 


Met Met Arg Thr Leu Val Thr Ser Gly Val Ser Ser Tyr Gln His Thr 
                485                 490                 495     


Ser Val Thr Leu Glu Phe Phe Glu Thr Val Val Arg Tyr Glu Lys Phe 
            500                 505                 510         


Phe Thr Val Glu Pro Gln His Ile Pro Cys Val Leu Met Ala Phe Leu 
        515                 520                 525             


Asp His Arg Gly Leu Arg His Ser Ser Ala Lys Val Arg Ser Arg Thr 
    530                 535                 540                 


Ala Tyr Leu Phe Ser Arg Phe Val Lys Ser Leu Asn Lys Gln Met Asn 
545                 550                 555                 560 


Pro Phe Ile Glu Asp Ile Leu Asn Arg Ile Gln Asp Leu Leu Glu Leu 
                565                 570                 575     


Ser Pro Pro Glu Asn Gly His Gln Ser Leu Leu Ser Ser Asp Asp Gln 
            580                 585                 590         


Leu Phe Ile Tyr Glu Thr Ala Gly Val Leu Ile Val Asn Ser Glu Tyr 
        595                 600                 605             


Pro Ala Glu Arg Lys Gln Ala Leu Met Arg Asn Leu Leu Thr Pro Leu 
    610                 615                 620                 


Met Glu Lys Phe Lys Ile Leu Leu Glu Lys Leu Met Leu Ala Gln Asp 
625                 630                 635                 640 


Glu Glu Arg Gln Ala Ser Leu Ala Asp Cys Leu Asn His Ala Val Gly 
                645                 650                 655     


Phe Ala Ser Arg Thr Ser Lys Ala Phe Ser Asn Lys Gln Thr Val Lys 
            660                 665                 670         


Gln Cys Gly Cys Ser Glu Val Tyr Leu Asp Cys Leu Gln Thr Phe Leu 
        675                 680                 685             


Pro Ala Leu Ser Cys Pro Leu Gln Lys Asp Ile Leu Arg Ser Gly Val 
    690                 695                 700                 


Arg Thr Phe Leu His Arg Met Ile Ile Cys Leu Glu Glu Glu Val Leu 
705                 710                 715                 720 


Pro Phe Ile Pro Ser Ala Ser Glu His Met Leu Lys Asp Cys Glu Ala 
                725                 730                 735     


Lys Asp Leu Gln Glu Phe Ile Pro Leu Ile Asn Gln Ile Thr Ala Lys 
            740                 745                 750         


Phe Lys Ile Gln Val Ser Pro Phe Leu Gln Gln Met Phe Met Pro Leu 
        755                 760                 765             


Leu His Ala Ile Phe Glu Val Leu Leu Arg Pro Ala Glu Glu Asn Asp 
    770                 775                 780                 


Gln Ser Ala Ala Leu Glu Lys Gln Met Leu Arg Arg Ser Tyr Phe Ala 
785                 790                 795                 800 


Phe Leu Gln Thr Val Thr Gly Ser Gly Met Ser Glu Val Ile Ala Asn 
                805                 810                 815     


Gln Gly Ala Glu Asn Val Glu Arg Val Leu Val Thr Val Ile Gln Gly 
            820                 825                 830         


Ala Val Glu Tyr Pro Asp Pro Ile Ala Gln Lys Thr Cys Phe Ile Ile 
        835                 840                 845             


Leu Ser Lys Leu Val Glu Leu Trp Gly Gly Lys Asp Gly Pro Val Gly 
    850                 855                 860                 


Phe Ala Asp Phe Val Tyr Lys His Ile Val Pro Ala Cys Phe Leu Ala 
865                 870                 875                 880 


Pro Leu Lys Gln Thr Phe Asp Leu Ala Asp Ala Gln Thr Val Leu Ala 
                885                 890                 895     


Leu Ser Glu Cys Ala Val Thr Leu Lys Thr Ile His Leu Lys Arg Gly 
            900                 905                 910         


Pro Glu Cys Val Gln Tyr Leu Gln Gln Glu Tyr Leu Pro Ser Leu Gln 
        915                 920                 925             


Val Ala Pro Glu Ile Ile Gln Glu Phe Cys Gln Ala Leu Gln Gln Pro 
    930                 935                 940                 


Asp Ala Lys Val Phe Lys Asn Tyr Leu Lys Val Phe Phe Gln Arg Ala 
945                 950                 955                 960 


Lys Pro 
        


<210> 5564
<211> 991
<212> PRT
<213> Homo sapiens

<400> 5564
Met Ala Glu Ser Phe Phe Ser Asp Phe Gly Leu Leu Trp Tyr Leu Lys 
1               5                   10                  15      


Glu Leu Arg Lys Glu Glu Phe Trp Lys Phe Lys Glu Leu Leu Lys Gln 
            20                  25                  30          


Pro Leu Glu Lys Phe Glu Leu Lys Pro Ile Pro Trp Ala Glu Leu Lys 
        35                  40                  45              


Lys Ala Ser Lys Glu Asp Val Ala Lys Leu Leu Asp Lys His Tyr Pro 
    50                  55                  60                  


Gly Lys Gln Ala Trp Glu Val Thr Leu Asn Leu Phe Leu Gln Ile Asn 
65                  70                  75                  80  


Arg Lys Asp Leu Trp Thr Lys Ala Gln Glu Glu Met Arg Asn Lys Leu 
                85                  90                  95      


Asn Pro Tyr Arg Lys His Met Lys Glu Thr Phe Gln Leu Ile Trp Glu 
            100                 105                 110         


Lys Glu Thr Cys Leu His Val Pro Glu His Phe Tyr Lys Glu Thr Met 
        115                 120                 125             


Lys Asn Glu Tyr Lys Glu Leu Asn Asp Ala Tyr Thr Ala Ala Ala Arg 
    130                 135                 140                 


Arg His Thr Val Val Leu Glu Gly Pro Asp Gly Ile Gly Lys Thr Thr 
145                 150                 155                 160 


Leu Leu Arg Lys Val Met Leu Asp Trp Ala Glu Gly Asn Leu Trp Lys 
                165                 170                 175     


Asp Arg Phe Thr Phe Val Phe Phe Leu Asn Val Cys Glu Met Asn Gly 
            180                 185                 190         


Ile Ala Glu Thr Ser Leu Leu Glu Leu Leu Ser Arg Asp Trp Pro Glu 
        195                 200                 205             


Ser Ser Glu Lys Ile Glu Asp Ile Phe Ser Gln Pro Glu Arg Ile Leu 
    210                 215                 220                 


Phe Ile Met Asp Gly Phe Glu Gln Leu Lys Phe Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Ala Asp Leu Ser Asp Asp Trp Arg Gln Arg Gln Pro Met Pro Ile Ile 
                245                 250                 255     


Leu Ser Ser Leu Leu Gln Lys Lys Met Leu Pro Glu Ser Ser Leu Leu 
            260                 265                 270         


Ile Ala Leu Gly Lys Leu Ala Met Gln Lys His Tyr Phe Met Leu Arg 
        275                 280                 285             


His Pro Lys Leu Ile Lys Leu Leu Gly Phe Ser Glu Ser Glu Lys Lys 
    290                 295                 300                 


Ser Tyr Phe Ser Tyr Phe Phe Gly Glu Lys Ser Lys Ala Leu Lys Val 
305                 310                 315                 320 


Phe Asn Phe Val Arg Asp Asn Gly Pro Leu Phe Ile Leu Cys His Asn 
                325                 330                 335     


Pro Phe Thr Cys Trp Leu Val Cys Thr Cys Val Lys Gln Arg Leu Glu 
            340                 345                 350         


Arg Gly Glu Asp Leu Glu Ile Asn Ser Gln Asn Thr Thr Tyr Leu Tyr 
        355                 360                 365             


Ala Ser Phe Leu Thr Thr Val Phe Lys Ala Gly Ser Gln Ser Phe Pro 
    370                 375                 380                 


Pro Lys Val Asn Arg Ala Arg Leu Lys Ser Leu Cys Ala Leu Ala Ala 
385                 390                 395                 400 


Glu Gly Ile Trp Thr Tyr Thr Phe Val Phe Ser His Gly Asp Leu Arg 
                405                 410                 415     


Arg Asn Gly Leu Ser Glu Ser Glu Gly Val Met Trp Val Gly Met Arg 
            420                 425                 430         


Leu Leu Gln Arg Arg Gly Asp Cys Phe Ala Phe Met His Leu Cys Ile 
        435                 440                 445             


Gln Glu Phe Cys Ala Ala Met Phe Tyr Leu Leu Lys Arg Pro Lys Asp 
    450                 455                 460                 


Asp Pro Asn Pro Ala Ile Gly Ser Ile Thr Gln Leu Val Arg Ala Ser 
465                 470                 475                 480 


Val Val Gln Pro Gln Thr Leu Leu Thr Gln Val Gly Ile Phe Met Phe 
                485                 490                 495     


Gly Ile Ser Thr Glu Glu Ile Val Ser Met Leu Glu Thr Ser Phe Gly 
            500                 505                 510         


Phe Pro Leu Ser Lys Asp Leu Lys Gln Glu Ile Thr Gln Cys Leu Glu 
        515                 520                 525             


Ser Leu Ser Gln Cys Glu Ala Asp Arg Glu Ala Ile Ala Phe Gln Glu 
    530                 535                 540                 


Leu Phe Ile Gly Leu Phe Glu Thr Gln Glu Lys Glu Phe Val Thr Lys 
545                 550                 555                 560 


Val Met Asn Phe Phe Glu Glu Val Phe Ile Tyr Ile Gly Asn Ile Glu 
                565                 570                 575     


His Leu Val Ile Ala Ser Phe Cys Leu Lys His Cys Gln His Leu Thr 
            580                 585                 590         


Thr Leu Arg Met Cys Val Glu Asn Ile Phe Pro Asp Asp Ser Gly Cys 
        595                 600                 605             


Ile Ser Asp Tyr Asn Glu Lys Leu Val Tyr Trp Arg Glu Leu Cys Ser 
    610                 615                 620                 


Met Phe Ile Thr Asn Lys Asn Phe Gln Ile Leu Asp Met Glu Asn Thr 
625                 630                 635                 640 


Ser Leu Asp Asp Pro Ser Leu Ala Ile Leu Cys Lys Ala Leu Ala Gln 
                645                 650                 655     


Pro Val Cys Lys Leu Arg Lys Leu Ile Phe Thr Ser Val Tyr Phe Gly 
            660                 665                 670         


His Asp Ser Glu Leu Phe Lys Ala Val Leu His Asn Pro His Leu Lys 
        675                 680                 685             


Leu Leu Ser Leu Tyr Gly Thr Ser Leu Ser Gln Ser Asp Ile Arg His 
    690                 695                 700                 


Leu Cys Glu Thr Leu Lys His Pro Met Cys Lys Ile Glu Glu Leu Ile 
705                 710                 715                 720 


Leu Gly Lys Cys Asp Ile Ser Ser Glu Val Cys Glu Asp Ile Ala Ser 
                725                 730                 735     


Val Leu Ala Cys Asn Ser Lys Leu Lys His Leu Ser Leu Val Glu Asn 
            740                 745                 750         


Pro Leu Arg Asp Glu Gly Met Thr Leu Leu Cys Glu Ala Leu Lys His 
        755                 760                 765             


Ser His Cys Ala Leu Glu Arg Leu Met Leu Met Tyr Cys Cys Leu Thr 
    770                 775                 780                 


Ser Val Ser Cys Asp Ser Ile Ser Glu Val Leu Leu Cys Ser Lys Ser 
785                 790                 795                 800 


Leu Ser Leu Leu Asp Leu Gly Ser Asn Ala Leu Glu Asp Asn Gly Val 
                805                 810                 815     


Ala Ser Leu Cys Ala Ala Leu Lys His Pro Gly Cys Ser Ile Arg Glu 
            820                 825                 830         


Leu Trp Leu Met Gly Cys Phe Leu Thr Ser Asp Ser Cys Lys Asp Ile 
        835                 840                 845             


Ala Ala Val Leu Ile Cys Asn Gly Lys Leu Lys Thr Leu Lys Leu Gly 
    850                 855                 860                 


His Asn Glu Ile Gly Asp Thr Gly Val Arg Gln Leu Cys Ala Ala Leu 
865                 870                 875                 880 


Gln His Pro His Cys Lys Leu Glu Cys Leu Gly Leu Gln Thr Cys Pro 
                885                 890                 895     


Ile Thr Arg Ala Cys Cys Asp Asp Ile Ala Ala Ala Leu Ile Ala Cys 
            900                 905                 910         


Lys Thr Leu Arg Ser Leu Asn Leu Asp Trp Ile Ala Leu Asp Ala Asp 
        915                 920                 925             


Ala Val Val Val Leu Cys Glu Ala Leu Ser His Pro Asp Cys Ala Leu 
    930                 935                 940                 


Gln Met Leu Gly Leu His Lys Ser Gly Phe Asp Glu Glu Thr Gln Lys 
945                 950                 955                 960 


Ile Leu Met Ser Val Glu Glu Lys Ile Pro His Leu Thr Ile Ser His 
                965                 970                 975     


Gly Pro Trp Ile Asp Glu Glu Tyr Lys Ile Arg Gly Val Leu Leu 
            980                 985                 990     


<210> 5565
<211> 177
<212> PRT
<213> Homo sapiens

<400> 5565
Met Ala Ala Val Lys Ala Ser Thr Ser Lys Ala Thr Arg Pro Trp Tyr 
1               5                   10                  15      


Ser His Pro Val Tyr Ala Arg Tyr Trp Gln His Tyr His Gln Ala Met 
            20                  25                  30          


Ala Trp Met Gln Ser His His Asn Ala Tyr Arg Lys Ala Val Glu Ser 
        35                  40                  45              


Cys Phe Asn Leu Pro Trp Tyr Leu Pro Ser Ala Leu Leu Pro Gln Ser 
    50                  55                  60                  


Ser Tyr Asp Asn Glu Ala Ala Tyr Pro Gln Ser Phe Tyr Asp His His 
65                  70                  75                  80  


Val Ala Trp Gln Asp Tyr Pro Cys Ser Ser Ser His Phe Arg Arg Ser 
                85                  90                  95      


Gly Gln His Pro Arg Tyr Ser Ser Arg Ile Gln Ala Ser Thr Lys Glu 
            100                 105                 110         


Asp Gln Ala Leu Ser Lys Glu Glu Glu Met Glu Thr Glu Ser Asp Ala 
        115                 120                 125             


Glu Val Glu Cys Asp Leu Ser Asn Met Glu Ile Thr Glu Glu Leu Arg 
    130                 135                 140                 


Gln Tyr Phe Ala Glu Thr Glu Arg His Arg Glu Glu Arg Arg Arg Gln 
145                 150                 155                 160 


Gln Gln Leu Asp Ala Glu Arg Leu Asp Ser Tyr Val Asn Ala Asp His 
                165                 170                 175     


Asp 
    


<210> 5566
<211> 500
<212> PRT
<213> Homo sapiens

<400> 5566
Met Val Gly Arg Ser Cys Gly Val Ala Thr Gln Arg Gln Gly Gly Gly 
1               5                   10                  15      


Gln Arg Pro Thr Asn Leu Ala Leu Thr Leu Ser Ser Ser Pro Ala His 
            20                  25                  30          


Ser Thr Ala Leu Pro Trp Leu Pro Pro Arg Ser Leu Gln Leu Leu Ser 
        35                  40                  45              


Gly His Ser Val Pro Ala Gln Pro Thr Pro His Leu Pro Ser Ala Cys 
    50                  55                  60                  


Gly Gly Pro Thr Arg Val Thr Leu Gly Glu Glu Arg Ala Trp Arg Ser 
65                  70                  75                  80  


His Gly Ser Asn Ala Gly Gly His Thr Cys Leu Pro Arg Arg Thr Ala 
                85                  90                  95      


Gly Ala Gly Ser Leu Thr Pro Gly Gly Glu Arg Gly Gly Asn Asn Ala 
            100                 105                 110         


Gly His Thr Val Val Val Asp Gly Lys Glu Tyr Asp Phe His Leu Leu 
        115                 120                 125             


Pro Ser Gly Ile Ile Asn Thr Lys Ala Val Ser Phe Ile Gly Asn Gly 
    130                 135                 140                 


Val Val Ile His Leu Pro Gly Leu Phe Glu Glu Ala Glu Lys Asn Glu 
145                 150                 155                 160 


Lys Lys Gly Leu Lys Asp Trp Glu Lys Arg Leu Ile Ile Ser Asp Arg 
                165                 170                 175     


Ala His Leu Val Phe Asp Phe His Gln Ala Val Asp Gly Leu Gln Glu 
            180                 185                 190         


Val Gln Arg Gln Ala Gln Glu Gly Lys Asn Ile Gly Thr Thr Lys Lys 
        195                 200                 205             


Gly Ile Gly Pro Thr Tyr Ser Ser Lys Ala Ala Arg Thr Gly Leu Arg 
    210                 215                 220                 


Ile Cys Asp Leu Leu Ser Asp Phe Asp Glu Phe Ser Ser Arg Phe Lys 
225                 230                 235                 240 


Asn Leu Ala His Gln His Gln Ser Met Phe Pro Thr Leu Glu Ile Asp 
                245                 250                 255     


Ile Glu Gly Gln Leu Lys Arg Leu Lys Gly Phe Ala Glu Arg Ile Arg 
            260                 265                 270         


Pro Met Val Arg Asp Gly Val Tyr Phe Met Tyr Glu Ala Leu His Gly 
        275                 280                 285             


Pro Pro Lys Lys Ile Leu Val Glu Gly Ala Asn Ala Ala Leu Leu Asp 
    290                 295                 300                 


Ile Asp Phe Gly Thr Tyr Pro Phe Val Thr Ser Ser Asn Cys Thr Val 
305                 310                 315                 320 


Gly Gly Val Cys Thr Gly Leu Gly Ile Pro Pro Gln Asn Ile Gly Asp 
                325                 330                 335     


Val Tyr Gly Val Val Lys Ala Tyr Thr Thr Arg Val Gly Ile Gly Ala 
            340                 345                 350         


Phe Pro Thr Glu Gln Ile Asn Glu Ile Gly Gly Leu Leu Gln Thr Arg 
        355                 360                 365             


Gly His Glu Trp Gly Val Thr Thr Gly Arg Lys Arg Arg Cys Gly Trp 
    370                 375                 380                 


Leu Asp Leu Met Ile Leu Arg Tyr Ala His Met Val Asn Gly Phe Thr 
385                 390                 395                 400 


Ala Leu Ala Leu Thr Lys Leu Asp Ile Leu Asp Val Leu Gly Glu Val 
                405                 410                 415     


Lys Val Gly Val Ser Tyr Lys Leu Asn Gly Lys Arg Ile Pro Tyr Phe 
            420                 425                 430         


Pro Ala Asn Gln Glu Met Leu Gln Lys Val Glu Val Glu Tyr Glu Thr 
        435                 440                 445             


Leu Pro Gly Trp Lys Ala Asp Thr Thr Gly Ala Arg Arg Trp Glu Asp 
    450                 455                 460                 


Leu Pro Pro Gln Ala Gln Asn Tyr Ile Arg Phe Val Glu Asn His Val 
465                 470                 475                 480 


Gly Val Ala Val Lys Trp Val Gly Val Gly Lys Ser Arg Glu Ser Met 
                485                 490                 495     


Ile Gln Leu Phe 
            500 


<210> 5567
<211> 155
<212> PRT
<213> Homo sapiens

<400> 5567
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Gln Asp Leu Cys Gln Glu Thr Cys Cys Cys Pro Ser Cys Cys Gln Thr 
            20                  25                  30          


Thr Cys Cys Arg Thr Thr Cys Tyr Arg Pro Ser Tyr Ser Val Ser Cys 
        35                  40                  45              


Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys 
    50                  55                  60                  


Cys Arg Pro Ser Cys Cys Val Pro Thr Cys Cys His Pro Ser Cys Cys 
65                  70                  75                  80  


Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys 
                85                  90                  95      


Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Asn Cys Cys Arg Pro 
            100                 105                 110         


Ser Cys Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly Arg Val 
        115                 120                 125             


Ser Cys His Thr Thr Cys Tyr Arg Pro Ala Cys Val Ile Ser Thr Cys 
    130                 135                 140                 


Pro Arg Pro Val Cys Cys Ala Ser Ser Cys Cys 
145                 150                 155 


<210> 5568
<211> 707
<212> PRT
<213> Homo sapiens

<400> 5568
Met Ala Ala Glu Ala Leu Ala Ala Glu Ala Val Ala Ser Arg Leu Glu 
1               5                   10                  15      


Arg Gln Glu Glu Asp Ile Arg Trp Leu Trp Ser Glu Val Glu Arg Leu 
            20                  25                  30          


Arg Asp Glu Gln Leu Asn Ala Pro Tyr Ser Cys Gln Ala Glu Gly Pro 
        35                  40                  45              


Cys Leu Thr Arg Glu Val Ala Gln Leu Arg Ala Glu Asn Cys Asp Leu 
    50                  55                  60                  


Arg His Arg Leu Cys Ser Leu Arg Leu Cys Leu Ala Glu Glu Arg Ser 
65                  70                  75                  80  


Arg Gln Ala Thr Leu Glu Ser Ala Glu Leu Glu Ala Ala Gln Glu Ala 
                85                  90                  95      


Gly Ala Gln Pro Pro Pro Ser Gln Ser Gln Asp Lys Asp Met Lys Lys 
            100                 105                 110         


Lys Lys Met Lys Glu Ser Glu Ala Asp Ser Glu Val Lys His Gln Pro 
        115                 120                 125             


Ile Phe Ile Lys Glu Arg Leu Lys Leu Phe Glu Ile Leu Lys Lys Asp 
    130                 135                 140                 


His Gln Leu Leu Leu Ala Ile Tyr Gly Lys Lys Gly Asp Thr Ser Asn 
145                 150                 155                 160 


Ile Ile Thr Val Arg Val Ala Asp Gly Gln Thr Val Gln Gly Glu Val 
                165                 170                 175     


Trp Lys Thr Thr Pro Tyr Gln Val Ala Ala Glu Ile Ser Gln Glu Leu 
            180                 185                 190         


Ala Glu Ser Thr Val Ile Ala Lys Val Asn Gly Glu Leu Trp Asp Leu 
        195                 200                 205             


Asp Arg Pro Leu Glu Gly Asp Ser Ser Leu Glu Leu Leu Thr Phe Asp 
    210                 215                 220                 


Asn Glu Lys Val Asn Thr Ala Thr Thr Thr Val Tyr Arg Cys Gly Pro 
225                 230                 235                 240 


Leu Ile Asp Leu Cys Lys Gly Pro His Val Arg His Thr Gly Lys Ile 
                245                 250                 255     


Lys Thr Ile Lys Ile Phe Lys Asn Ser Ser Thr Tyr Trp Glu Gly Asn 
            260                 265                 270         


Pro Glu Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp 
        275                 280                 285             


Asn Lys Met Met Arg Asp Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn 
    290                 295                 300                 


Arg Asp His Arg Lys Ile Gly Lys Glu Gln Glu Leu Phe Phe Phe His 
305                 310                 315                 320 


Asp Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Arg Gly Ala Phe Ile 
                325                 330                 335     


Tyr Asn Thr Leu Thr Asp Phe Ile Arg Glu Glu Tyr His Lys Arg Asp 
            340                 345                 350         


Phe Thr Glu Val Leu Ser Pro Asn Met Tyr Asn Ser Lys Leu Trp Glu 
        355                 360                 365             


Ala Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Thr Phe Glu 
    370                 375                 380                 


Ile Glu Lys Asp Thr Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His 
385                 390                 395                 400 


Cys Leu Met Phe Ala His Arg Pro Arg Ser Trp Arg Glu Met Pro Ile 
                405                 410                 415     


Arg Phe Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Thr 
            420                 425                 430         


Leu Ser Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His 
        435                 440                 445             


Ile Phe Cys Thr Val Glu Gln Ile Glu Glu Glu Ile Lys Gly Cys Leu 
    450                 455                 460                 


Gln Phe Leu Gln Ser Val Tyr Ser Thr Phe Gly Phe Ser Phe Gln Leu 
465                 470                 475                 480 


Asn Leu Ser Thr Arg Pro Glu Asn Phe Leu Gly Glu Ile Glu Met Trp 
                485                 490                 495     


Asn Glu Ala Glu Lys Gln Leu Gln Asn Ser Leu Met Asp Phe Gly Glu 
            500                 505                 510         


Pro Trp Lys Met Asn Pro Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile 
        515                 520                 525             


Asp Ile Lys Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr 
    530                 535                 540                 


Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val 
545                 550                 555                 560 


Ser Lys Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Ile His Arg Ala 
                565                 570                 575     


Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Ser Glu Asn Tyr 
            580                 585                 590         


Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Ile 
        595                 600                 605             


Pro Val Gly Pro Thr Cys Glu Lys Tyr Ala Leu Gln Val Ser Ser Glu 
    610                 615                 620                 


Phe Phe Glu Glu Gly Phe Met Ala Asp Val Asp Leu Asp His Ser Cys 
625                 630                 635                 640 


Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe 
                645                 650                 655     


Ile Leu Val Val Gly Glu Lys Glu Lys Ile Asp Asn Ala Val Asn Val 
            660                 665                 670         


Arg Thr Arg Asp Asn Lys Ile His Gly Glu Ile Leu Val Thr Ser Ala 
        675                 680                 685             


Ile Asp Lys Leu Lys Asn Leu Arg Lys Thr Arg Thr Leu Asn Ala Glu 
    690                 695                 700                 


Glu Ala Phe 
705         


<210> 5569
<211> 271
<212> PRT
<213> Homo sapiens

<400> 5569
Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Phe Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Glu Tyr 
                85                  90                  95      


Gly Ser Gln Gln Val Ala Asp Leu Thr Leu Asn Leu Asp Asp Tyr Ile 
            100                 105                 110         


Asp Ala Glu His Leu Gly Asp Phe His Arg Thr Tyr Lys Asn Ser Glu 
        115                 120                 125             


Glu Leu Arg Ser Arg Ile Val Ser Gly Ile Ile Thr Pro Ile His Glu 
    130                 135                 140                 


Gln Trp Glu Lys Ala Asn Val Ser Ser Pro His Arg Glu Phe Pro Pro 
145                 150                 155                 160 


Ala Thr Ala Arg Glu Val Asp Pro Leu Arg Ile Pro Pro His His Pro 
                165                 170                 175     


His Thr Ser Arg Gln Pro Pro Trp Cys Asp Pro Leu Gly Pro Phe Val 
            180                 185                 190         


Val Gly Gly Glu Asp Leu Asp Pro Phe Gly Pro Arg Arg Gly Gly Met 
        195                 200                 205             


Ile Val Asp Pro Leu Arg Ser Gly Phe Pro Arg Ala Leu Ile Asp Pro 
    210                 215                 220                 


Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro Gly Ala Val Pro Pro Gly 
225                 230                 235                 240 


Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly Thr Ser Pro Pro Gly Pro 
                245                 250                 255     


Asn Pro Asp His Leu Pro Pro Pro Gly Tyr Asp Asp Met Tyr Leu 
            260                 265                 270     


<210> 5570
<211> 157
<212> PRT
<213> Homo sapiens

<400> 5570
Met Ala Thr Pro Pro Lys Arg Arg Ala Val Glu Ala Thr Gly Glu Lys 
1               5                   10                  15      


Val Leu Arg Tyr Glu Thr Phe Ile Ser Asp Val Leu Gln Arg Asp Leu 
            20                  25                  30          


Arg Lys Val Leu Asp His Arg Asp Lys Val Tyr Glu Gln Leu Ala Lys 
        35                  40                  45              


Tyr Leu Gln Leu Arg Asn Val Ile Glu Arg Leu Gln Glu Ala Lys His 
    50                  55                  60                  


Ser Glu Leu Tyr Met Gln Val Asp Leu Gly Cys Asn Phe Phe Val Asp 
65                  70                  75                  80  


Thr Val Val Pro Asp Thr Ser Arg Ile Tyr Val Ala Leu Gly Tyr Gly 
                85                  90                  95      


Phe Phe Leu Glu Leu Thr Leu Ala Glu Ala Leu Lys Phe Ile Asp Arg 
            100                 105                 110         


Lys Ser Ser Leu Leu Thr Glu Leu Ser Asn Ser Leu Thr Lys Asp Ser 
        115                 120                 125             


Met Asn Ile Lys Ala His Ile His Met Leu Leu Glu Gly Leu Arg Glu 
    130                 135                 140                 


Leu Gln Gly Leu Gln Asn Phe Pro Glu Lys Pro His His 
145                 150                 155         


<210> 5571
<211> 180
<212> PRT
<213> Homo sapiens

<400> 5571
Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210> 5572
<211> 206
<212> PRT
<213> Homo sapiens

<400> 5572
Met Thr Ala Ser Val Leu Arg Ser Ile Ser Leu Ala Leu Arg Pro Thr 
1               5                   10                  15      


Ser Gly Leu Leu Gly Thr Trp Gln Thr Gln Leu Arg Glu Thr His Gln 
            20                  25                  30          


Arg Ala Ser Leu Leu Ser Phe Trp Glu Leu Ile Pro Met Arg Ser Glu 
        35                  40                  45              


Pro Leu Arg Lys Lys Lys Lys Val Asp Pro Lys Lys Asp Gln Glu Ala 
    50                  55                  60                  


Lys Glu Arg Leu Lys Arg Lys Ile Arg Lys Leu Glu Lys Ala Thr Gln 
65                  70                  75                  80  


Glu Leu Ile Pro Ile Glu Asp Phe Ile Thr Pro Leu Lys Phe Leu Asp 
                85                  90                  95      


Lys Ala Arg Glu Arg Pro Gln Val Glu Leu Thr Phe Glu Glu Thr Glu 
            100                 105                 110         


Arg Arg Ala Leu Leu Leu Lys Lys Trp Ser Leu Tyr Lys Gln Gln Glu 
        115                 120                 125             


Arg Lys Met Glu Arg Asp Thr Ile Arg Ala Met Leu Glu Ala Gln Gln 
    130                 135                 140                 


Glu Ala Leu Glu Glu Leu Gln Leu Glu Ser Pro Lys Leu His Ala Glu 
145                 150                 155                 160 


Ala Ile Lys Arg Asp Pro Asn Leu Phe Pro Phe Glu Lys Glu Gly Pro 
                165                 170                 175     


His Tyr Thr Pro Pro Ile Pro Asn Tyr Gln Pro Pro Glu Gly Arg Tyr 
            180                 185                 190         


Asn Asp Ile Thr Lys Val Tyr Thr Gln Val Glu Phe Lys Arg 
        195                 200                 205     


<210> 5573
<211> 2320
<212> PRT
<213> Homo sapiens

<400> 5573
Met Ala Glu Pro Ser Ser Ala Arg Arg Pro Val Pro Leu Ile Glu Ser 
1               5                   10                  15      


Glu Leu Tyr Phe Leu Ile Ala Arg Tyr Leu Ser Ala Gly Pro Cys Arg 
            20                  25                  30          


Arg Ala Ala Gln Val Leu Val Gln Glu Leu Glu Gln Tyr Gln Leu Leu 
        35                  40                  45              


Pro Lys Arg Leu Asp Trp Glu Gly Asn Glu His Asn Arg Ser Tyr Glu 
    50                  55                  60                  


Glu Leu Val Leu Ser Asn Lys His Val Ala Pro Asp His Leu Leu Gln 
65                  70                  75                  80  


Ile Cys Gln Arg Ile Gly Pro Met Leu Asp Lys Glu Ile Pro Pro Ser 
                85                  90                  95      


Ile Ser Arg Val Thr Ser Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu 
            100                 105                 110         


Arg Thr Ala Lys Asp Cys Arg His Thr Val Trp Lys Gly Ser Ala Phe 
        115                 120                 125             


Ala Ala Leu His Arg Gly Arg Pro Pro Glu Met Pro Val Asn Tyr Gly 
    130                 135                 140                 


Ser Pro Pro Asn Leu Val Glu Ile His Arg Gly Lys Gln Leu Thr Gly 
145                 150                 155                 160 


Cys Ser Thr Phe Ser Thr Ala Phe Pro Gly Thr Met Tyr Gln His Ile 
                165                 170                 175     


Lys Met His Arg Arg Ile Leu Gly His Leu Ser Ala Val Tyr Cys Val 
            180                 185                 190         


Ala Phe Asp Arg Thr Gly His Arg Ile Phe Thr Gly Ser Asp Asp Cys 
        195                 200                 205             


Leu Val Lys Ile Trp Ser Thr His Asn Gly Arg Leu Leu Ser Thr Leu 
    210                 215                 220                 


Arg Gly His Ser Ala Glu Ile Ser Asp Met Ala Val Asn Tyr Glu Asn 
225                 230                 235                 240 


Thr Met Ile Ala Ala Gly Ser Cys Asp Lys Ile Ile Arg Val Trp Cys 
                245                 250                 255     


Leu Arg Thr Cys Ala Pro Val Ala Val Leu Gln Gly His Thr Gly Ser 
            260                 265                 270         


Ile Thr Ser Leu Gln Phe Ser Pro Met Ala Lys Gly Ser Gln Arg Tyr 
        275                 280                 285             


Met Val Ser Thr Gly Ala Asp Gly Thr Val Cys Phe Trp Gln Trp Asp 
    290                 295                 300                 


Leu Glu Ser Leu Lys Phe Ser Pro Arg Pro Leu Lys Phe Thr Glu Lys 
305                 310                 315                 320 


Pro Arg Pro Gly Val Gln Met Leu Cys Ser Ser Phe Ser Val Gly Gly 
                325                 330                 335     


Met Phe Leu Ala Thr Gly Ser Thr Asp His Val Ile Arg Met Tyr Phe 
            340                 345                 350         


Leu Gly Phe Glu Ala Pro Glu Lys Ile Ala Glu Leu Glu Ser His Thr 
        355                 360                 365             


Asp Lys Val Asp Ser Ile Gln Phe Cys Asn Asn Gly Asp Arg Phe Leu 
    370                 375                 380                 


Ser Gly Ser Arg Asp Gly Thr Ala Arg Ile Trp Arg Phe Glu Gln Leu 
385                 390                 395                 400 


Glu Trp Arg Ser Ile Leu Leu Asp Met Ala Thr Arg Ile Ser Gly Asp 
                405                 410                 415     


Leu Ser Ser Glu Glu Glu Arg Phe Met Lys Pro Lys Val Thr Met Ile 
            420                 425                 430         


Ala Trp Asn Gln Asn Asp Ser Ile Val Val Thr Ala Val Asn Asp His 
        435                 440                 445             


Val Leu Lys Val Trp Asn Ser Tyr Thr Gly Gln Leu Leu His Asn Leu 
    450                 455                 460                 


Met Gly His Ala Asp Glu Val Phe Val Leu Glu Thr His Pro Phe Asp 
465                 470                 475                 480 


Ser Arg Ile Met Leu Ser Ala Gly His Asp Gly Ser Ile Phe Ile Trp 
                485                 490                 495     


Asp Ile Thr Lys Gly Thr Lys Met Lys His Tyr Phe Asn Met Ile Glu 
            500                 505                 510         


Gly Gln Gly His Gly Ala Val Phe Asp Cys Lys Phe Ser Gln Asp Gly 
        515                 520                 525             


Gln His Phe Ala Cys Thr Asp Ser His Gly His Leu Leu Ile Phe Gly 
    530                 535                 540                 


Phe Gly Cys Ser Lys Pro Tyr Glu Lys Ile Pro Asp Gln Met Phe Phe 
545                 550                 555                 560 


His Thr Asp Tyr Arg Pro Leu Ile Arg Asp Ser Asn Asn Tyr Val Leu 
                565                 570                 575     


Asp Glu Gln Thr Gln Gln Ala Pro His Leu Met Pro Pro Pro Phe Leu 
            580                 585                 590         


Val Asp Val Asp Gly Asn Pro His Pro Thr Lys Tyr Gln Arg Leu Val 
        595                 600                 605             


Pro Gly Arg Glu Asn Ser Ala Asp Glu His Leu Ile Pro Gln Leu Gly 
    610                 615                 620                 


Tyr Val Ala Thr Ser Asp Gly Glu Val Ile Glu Gln Ile Ile Ser Leu 
625                 630                 635                 640 


Gln Thr Asn Asp Asn Asp Glu Arg Ser Pro Glu Ser Ser Ile Leu Asp 
                645                 650                 655     


Gly Met Ile Arg Gln Leu Gln Gln Gln Gln Asp Gln Arg Met Gly Ala 
            660                 665                 670         


Asp Gln Asp Thr Ile Pro Arg Gly Leu Ser Asn Gly Glu Glu Thr Pro 
        675                 680                 685             


Arg Arg Gly Phe Arg Arg Leu Ser Leu Asp Ile Gln Ser Pro Pro Asn 
    690                 695                 700                 


Ile Gly Leu Arg Arg Ser Gly Gln Val Glu Gly Val Arg Gln Met His 
705                 710                 715                 720 


Gln Asn Ala Pro Arg Ser Gln Ile Ala Thr Glu Arg Asp Leu Gln Ala 
                725                 730                 735     


Trp Lys Arg Arg Val Val Val Pro Glu Val Pro Leu Gly Ile Phe Arg 
            740                 745                 750         


Lys Leu Glu Asp Phe Arg Leu Glu Lys Gly Glu Glu Glu Arg Asn Leu 
        755                 760                 765             


Tyr Ile Ile Gly Arg Lys Arg Lys Thr Leu Gln Leu Ser His Lys Ser 
    770                 775                 780                 


Asp Ser Val Val Leu Val Ser Gln Ser Arg Gln Arg Thr Cys Arg Arg 
785                 790                 795                 800 


Lys Tyr Pro Asn Tyr Gly Arg Arg Asn Arg Ser Trp Arg Glu Leu Ser 
                805                 810                 815     


Ser Gly Asn Glu Ser Ser Ser Ser Val Arg His Glu Thr Ser Cys Asp 
            820                 825                 830         


Gln Ser Glu Gly Ser Gly Ser Ser Glu Glu Asp Glu Trp Arg Ser Asp 
        835                 840                 845             


Arg Lys Ser Glu Ser Tyr Ser Glu Ser Ser Ser Asp Ser Ser Ser Arg 
    850                 855                 860                 


Tyr Ser Asp Trp Thr Ala Asp Ala Gly Ile Asn Leu Gln Pro Pro Leu 
865                 870                 875                 880 


Arg Thr Ser Cys Arg Arg Arg Ile Thr Arg Phe Cys Ser Ser Ser Glu 
                885                 890                 895     


Asp Glu Ile Ser Thr Glu Asn Leu Ser Pro Pro Lys Arg Arg Arg Lys 
            900                 905                 910         


Arg Lys Lys Glu Asn Lys Pro Lys Lys Glu Asn Leu Arg Arg Met Thr 
        915                 920                 925             


Pro Ala Glu Leu Ala Asn Met Glu His Leu Tyr Glu Phe His Pro Pro 
    930                 935                 940                 


Val Trp Ile Thr Asp Thr Thr Leu Arg Lys Ser Pro Phe Val Pro Gln 
945                 950                 955                 960 


Met Gly Asp Glu Val Ile Tyr Phe Arg Gln Gly His Glu Ala Tyr Ile 
                965                 970                 975     


Glu Ala Val Arg Arg Asn Asn Ile Tyr Glu Leu Asn Pro Asn Lys Glu 
            980                 985                 990         


Pro Trp Arg Lys Met Asp Leu Arg  Asp Gln Glu Leu Val  Lys Ile Val 
        995                 1000                 1005             


Gly Ile  Arg Tyr Glu Val Gly  Pro Pro Thr Leu Cys  Cys Leu Lys 
    1010                 1015                 1020             


Leu Ala  Phe Ile Asp Pro Ala  Thr Gly Lys Leu Met  Asp Lys Ser 
    1025                 1030                 1035             


Phe Ser  Ile Arg Tyr His Asp  Met Pro Asp Val Ile  Asp Phe Leu 
    1040                 1045                 1050             


Val Leu  Arg Gln Phe Tyr Asp  Glu Ala Arg Gln Arg  Asn Trp Gln 
    1055                 1060                 1065             


Ser Cys  Asp Arg Phe Arg Ser  Ile Ile Asp Asp Ala  Trp Trp Phe 
    1070                 1075                 1080             


Gly Thr  Val Leu Ser Gln Glu  Pro Tyr Gln Pro Gln  Tyr Pro Asp 
    1085                 1090                 1095             


Ser His  Phe Gln Cys Tyr Ile  Val Arg Trp Asp Asn  Thr Glu Ile 
    1100                 1105                 1110             


Glu Lys  Leu Ser Pro Trp Asp  Met Glu Pro Ile Pro  Asp Asn Val 
    1115                 1120                 1125             


Asp Pro  Pro Glu Glu Leu Gly  Ala Ser Ile Ser Val  Thr Thr Asp 
    1130                 1135                 1140             


Glu Leu  Glu Lys Leu Leu Tyr  Lys Pro Gln Ala Gly  Glu Trp Gly 
    1145                 1150                 1155             


Gln Lys  Ser Arg Asp Glu Glu  Cys Asp Arg Ile Ile  Ser Gly Ile 
    1160                 1165                 1170             


Asp Gln  Leu Leu Asn Leu Asp  Ile Ala Ala Ala Phe  Ala Gly Pro 
    1175                 1180                 1185             


Val Asp  Leu Cys Thr Tyr Pro  Lys Tyr Cys Thr Val  Val Ala Tyr 
    1190                 1195                 1200             


Pro Thr  Asp Leu Tyr Thr Ile  Arg Met Arg Leu Val  Asn Arg Phe 
    1205                 1210                 1215             


Tyr Arg  Arg Leu Ser Ala Leu  Val Trp Glu Val Arg  Tyr Ile Glu 
    1220                 1225                 1230             


His Asn  Ala Arg Thr Phe Asn  Glu Pro Glu Ser Val  Ile Ala Arg 
    1235                 1240                 1245             


Ser Ala  Lys Lys Ile Thr Asp  Gln Leu Leu Lys Phe  Ile Lys Asn 
    1250                 1255                 1260             


Gln His  Cys Thr Asn Ile Ser  Glu Leu Ser Asn Thr  Ser Glu Asn 
    1265                 1270                 1275             


Asp Glu  Gln Asn Ala Glu Asp  Leu Asp Asp Ser Asp  Leu Pro Lys 
    1280                 1285                 1290             


Thr Ser  Ser Gly Arg Arg Arg  Val His Asp Gly Lys  Lys Ser Ile 
    1295                 1300                 1305             


Arg Ala  Thr Asn Tyr Val Glu  Ser Asn Trp Lys Lys  Gln Cys Lys 
    1310                 1315                 1320             


Glu Leu  Val Asn Leu Ile Phe  Gln Cys Glu Asp Ser  Glu Pro Phe 
    1325                 1330                 1335             


Arg Gln  Pro Val Asp Leu Val  Glu Tyr Pro Asp Tyr  Arg Asp Ile 
    1340                 1345                 1350             


Ile Asp  Thr Pro Met Asp Phe  Gly Thr Val Arg Glu  Thr Leu Asp 
    1355                 1360                 1365             


Ala Gly  Asn Tyr Asp Ser Pro  Leu Glu Phe Cys Lys  Asp Ile Arg 
    1370                 1375                 1380             


Leu Ile  Phe Ser Asn Ala Lys  Ala Tyr Thr Pro Asn  Lys Arg Ser 
    1385                 1390                 1395             


Lys Ile  Tyr Ser Met Thr Leu  Arg Leu Ser Ala Leu  Phe Glu Glu 
    1400                 1405                 1410             


Lys Met  Lys Lys Ile Ser Ser  Asp Phe Lys Ile Gly  Gln Lys Phe 
    1415                 1420                 1425             


Asn Glu  Lys Leu Arg Arg Ser  Gln Arg Phe Lys Gln  Arg Gln Asn 
    1430                 1435                 1440             


Cys Lys  Gly Asp Ser Gln Pro  Asn Lys Ser Ile Arg  Asn Leu Lys 
    1445                 1450                 1455             


Pro Lys  Arg Leu Lys Ser Gln  Thr Lys Ile Ile Pro  Glu Leu Val 
    1460                 1465                 1470             


Gly Ser  Pro Thr Gln Ser Thr  Ser Ser Arg Thr Ala  Tyr Leu Gly 
    1475                 1480                 1485             


Thr His  Lys Thr Ser Ala Gly  Ile Ser Ser Gly Val  Thr Ser Gly 
    1490                 1495                 1500             


Asp Ser  Ser Asp Ser Ala Glu  Ser Ser Glu Arg Arg  Lys Arg Asn 
    1505                 1510                 1515             


Arg Pro  Ile Thr Asn Gly Ser  Thr Leu Ser Glu Ser  Glu Val Glu 
    1520                 1525                 1530             


Asp Ser  Leu Ala Thr Ser Leu  Ser Ser Ser Ala Ser  Ser Ser Ser 
    1535                 1540                 1545             


Glu Glu  Ser Lys Glu Ser Ser  Arg Ala Arg Glu Ser  Ser Ser Arg 
    1550                 1555                 1560             


Ser Gly  Leu Ser Arg Ser Ser  Asn Leu Arg Val Thr  Arg Thr Arg 
    1565                 1570                 1575             


Ala Ala  Gln Arg Lys Thr Gly  Pro Val Ser Leu Ala  Asn Gly Cys 
    1580                 1585                 1590             


Gly Arg  Lys Ala Thr Arg Lys  Arg Val Tyr Leu Ser  Asp Ser Asp 
    1595                 1600                 1605             


Asn Asn  Ser Leu Glu Thr Gly  Glu Ile Leu Lys Ala  Arg Ala Gly 
    1610                 1615                 1620             


Asn Asn  Arg Lys Val Leu Arg  Lys Cys Ala Ala Val  Ala Ala Asn 
    1625                 1630                 1635             


Lys Ile  Lys Leu Met Ser Asp  Val Glu Glu Asn Ser  Ser Ser Glu 
    1640                 1645                 1650             


Ser Val  Cys Ser Gly Arg Lys  Leu Pro His Arg Asn  Ala Ser Ala 
    1655                 1660                 1665             


Val Ala  Arg Lys Lys Leu Leu  His Asn Ser Glu Asp  Glu Gln Ser 
    1670                 1675                 1680             


Leu Lys  Ser Glu Ile Glu Glu  Glu Glu Leu Lys Asp  Glu Asn Gln 
    1685                 1690                 1695             


Leu Leu  Pro Val Ser Ser Ser  His Thr Ala Gln Ser  Asn Val Asp 
    1700                 1705                 1710             


Glu Ser  Glu Asn Arg Asp Ser  Glu Ser Glu Ser Asp  Leu Arg Val 
    1715                 1720                 1725             


Ala Arg  Lys Asn Trp His Ala  Asn Gly Tyr Lys Ser  His Thr Pro 
    1730                 1735                 1740             


Ala Pro  Ser Lys Thr Lys Phe  Leu Lys Ile Glu Ser  Ser Glu Glu 
    1745                 1750                 1755             


Asp Ser  Lys Ser His Asp Ser  Asp His Ala Cys Asn  Arg Thr Ala 
    1760                 1765                 1770             


Gly Pro  Ser Thr Ser Val Gln  Lys Leu Lys Ala Glu  Ser Ile Ser 
    1775                 1780                 1785             


Glu Glu  Ala Asp Ser Glu Pro  Gly Arg Ser Gly Gly  Arg Lys Tyr 
    1790                 1795                 1800             


Asn Thr  Phe His Lys Asn Ala  Ser Phe Phe Lys Lys  Thr Lys Ile 
    1805                 1810                 1815             


Leu Ser  Asp Ser Glu Asp Ser  Glu Ser Glu Glu Gln  Asp Arg Glu 
    1820                 1825                 1830             


Asp Gly  Lys Cys His Lys Met  Glu Met Asn Pro Ile  Ser Gly Asn 
    1835                 1840                 1845             


Leu Asn  Cys Asp Pro Ile Ala  Met Ser Gln Cys Ser  Ser Asp His 
    1850                 1855                 1860             


Gly Cys  Glu Thr Asp Leu Asp  Ser Asp Asp Asp Lys  Ile Glu Lys 
    1865                 1870                 1875             


Pro Asn  Asn Phe Met Lys Asp  Ser Ala Ser Gln Asp  Asn Gly Leu 
    1880                 1885                 1890             


Ser Arg  Lys Ile Ser Arg Lys  Arg Val Cys Ser Ser  Asp Ser Asp 
    1895                 1900                 1905             


Ser Ser  Leu Gln Val Val Lys  Lys Ser Ser Lys Ala  Arg Thr Gly 
    1910                 1915                 1920             


Leu Leu  Arg Ile Thr Arg Arg  Cys Ala Ala Thr Ala  Ala Asn Lys 
    1925                 1930                 1935             


Ile Lys  Leu Met Ser Asp Val  Glu Asp Val Ser Leu  Glu Asn Val 
    1940                 1945                 1950             


His Thr  Arg Ser Lys Asn Gly  Arg Lys Lys Pro Leu  His Leu Ala 
    1955                 1960                 1965             


Cys Thr  Thr Ala Lys Lys Lys  Leu Ser Asp Cys Glu  Gly Ser Val 
    1970                 1975                 1980             


His Cys  Glu Val Pro Ser Glu  Gln Tyr Ala Cys Glu  Gly Lys Pro 
    1985                 1990                 1995             


Pro Asp  Pro Asp Ser Glu Gly  Ser Thr Lys Val Leu  Ser Gln Ala 
    2000                 2005                 2010             


Leu Asn  Gly Asp Ser Asp Ser  Glu Asp Met Leu Asn  Ser Glu His 
    2015                 2020                 2025             


Lys His  Arg His Thr Asn Ile  His Lys Ile Asp Ala  Pro Ser Lys 
    2030                 2035                 2040             


Arg Lys  Ser Ser Ser Val Thr  Ser Ser Gly Glu Asp  Ser Lys Ser 
    2045                 2050                 2055             


His Ile  Pro Gly Ser Glu Thr  Asp Arg Thr Phe Ser  Ser Glu Ser 
    2060                 2065                 2070             


Thr Leu  Ala Gln Lys Ala Thr  Ala Glu Asn Asn Phe  Glu Val Glu 
    2075                 2080                 2085             


Leu Asn  Tyr Gly Leu Arg Arg  Trp Asn Gly Arg Arg  Leu Arg Thr 
    2090                 2095                 2100             


Tyr Gly  Lys Ala Pro Phe Ser  Lys Thr Lys Val Ile  His Asp Ser 
    2105                 2110                 2115             


Gln Glu  Thr Ala Glu Lys Glu  Val Lys Arg Lys Arg  Ser His Pro 
    2120                 2125                 2130             


Glu Leu  Glu Asn Val Lys Ile  Ser Glu Thr Thr Gly  Asn Ser Lys 
    2135                 2140                 2145             


Phe Arg  Pro Asp Thr Ser Ser  Lys Ser Ser Asp Leu  Gly Ser Val 
    2150                 2155                 2160             


Thr Glu  Ser Asp Ile Asp Cys  Thr Asp Asn Thr Lys  Thr Lys Arg 
    2165                 2170                 2175             


Arg Lys  Thr Lys Gly Lys Ala  Lys Val Val Arg Lys  Glu Phe Val 
    2180                 2185                 2190             


Pro Arg  Asp Arg Glu Pro Asn  Thr Lys Val Arg Thr  Cys Met His 
    2195                 2200                 2205             


Asn Gln  Lys Asp Ala Val Gln  Met Pro Ser Glu Thr  Leu Lys Ala 
    2210                 2215                 2220             


Lys Met  Val Pro Glu Lys Val  Pro Arg Arg Cys Ala  Thr Val Ala 
    2225                 2230                 2235             


Ala Asn  Lys Ile Lys Ile Met  Ser Asn Leu Lys Glu  Thr Ile Ser 
    2240                 2245                 2250             


Gly Pro  Glu Asn Val Trp Ile  Arg Lys Ser Ser Arg  Lys Leu Pro 
    2255                 2260                 2265             


His Arg  Asn Ala Ser Ala Ala  Ala Lys Lys Lys Leu  Leu Asn Val 
    2270                 2275                 2280             


Tyr Lys  Glu Asp Asp Thr Thr  Ile Asn Ser Glu Ser  Glu Lys Glu 
    2285                 2290                 2295             


Leu Glu  Asp Ile Asn Arg Lys  Met Leu Phe Leu Arg  Gly Phe Arg 
    2300                 2305                 2310             


Ser Trp  Lys Glu Asn Ala Gln  
    2315                 2320 


<210> 5574
<211> 986
<212> PRT
<213> Homo sapiens

<400> 5574
Met Ala Glu Ser Phe Phe Ser Asp Phe Gly Leu Leu Trp Tyr Leu Lys 
1               5                   10                  15      


Glu Leu Arg Lys Glu Glu Phe Trp Lys Phe Lys Glu Leu Leu Lys Gln 
            20                  25                  30          


Pro Leu Glu Lys Phe Glu Leu Lys Pro Ile Pro Trp Ala Glu Leu Lys 
        35                  40                  45              


Lys Ala Ser Lys Glu Asp Val Ala Lys Leu Leu Asp Lys His Tyr Pro 
    50                  55                  60                  


Gly Lys Gln Ala Trp Glu Val Thr Leu Asn Leu Phe Leu Gln Ile Asn 
65                  70                  75                  80  


Arg Lys Asp Leu Trp Thr Lys Ala Gln Glu Glu Met Arg Asn Lys Leu 
                85                  90                  95      


Asn Pro Tyr Arg Lys His Met Lys Glu Thr Phe Gln Leu Ile Trp Glu 
            100                 105                 110         


Lys Glu Thr Cys Leu His Val Pro Glu His Phe Tyr Lys Glu Thr Met 
        115                 120                 125             


Lys Asn Glu Tyr Lys Glu Leu Asn Asp Ala Tyr Thr Ala Ala Ala Arg 
    130                 135                 140                 


Arg His Thr Val Val Leu Glu Gly Pro Asp Gly Ile Gly Lys Thr Thr 
145                 150                 155                 160 


Leu Leu Arg Lys Val Met Leu Asp Trp Ala Glu Gly Asn Leu Trp Lys 
                165                 170                 175     


Asp Arg Phe Thr Phe Val Phe Phe Leu Asn Val Cys Glu Met Asn Gly 
            180                 185                 190         


Ile Ala Glu Thr Ser Leu Leu Glu Leu Leu Ser Arg Asp Trp Pro Glu 
        195                 200                 205             


Ser Ser Glu Lys Ile Glu Asp Ile Phe Ser Gln Pro Glu Arg Ile Leu 
    210                 215                 220                 


Phe Ile Met Asp Gly Phe Glu Gln Leu Lys Phe Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Ala Asp Leu Ser Asp Asp Trp Arg Gln Arg Gln Pro Met Pro Ile Ile 
                245                 250                 255     


Leu Ser Ser Leu Leu Gln Lys Lys Met Leu Pro Glu Ser Ser Leu Leu 
            260                 265                 270         


Ile Ala Leu Gly Lys Leu Ala Met Gln Lys His Tyr Phe Met Leu Arg 
        275                 280                 285             


His Pro Lys Leu Ile Lys Leu Leu Gly Phe Ser Glu Ser Glu Lys Lys 
    290                 295                 300                 


Ser Tyr Phe Ser Tyr Phe Phe Gly Glu Lys Ser Lys Ala Leu Lys Val 
305                 310                 315                 320 


Phe Asn Phe Val Arg Asp Asn Gly Pro Leu Phe Ile Leu Cys His Asn 
                325                 330                 335     


Pro Phe Thr Cys Trp Leu Val Cys Thr Cys Val Lys Gln Arg Leu Glu 
            340                 345                 350         


Arg Gly Glu Asp Leu Glu Ile Asn Ser Gln Asn Thr Thr Tyr Leu Tyr 
        355                 360                 365             


Ala Ser Phe Leu Thr Thr Val Phe Lys Ala Gly Ser Gln Ser Phe Pro 
    370                 375                 380                 


Pro Lys Val Asn Arg Ala Arg Leu Lys Ser Leu Cys Ala Leu Ala Ala 
385                 390                 395                 400 


Glu Gly Ile Trp Thr Tyr Thr Phe Val Phe Ser His Gly Asp Leu Arg 
                405                 410                 415     


Arg Asn Gly Leu Ser Glu Ser Glu Gly Val Met Trp Val Gly Met Arg 
            420                 425                 430         


Leu Leu Gln Arg Arg Gly Asp Cys Phe Ala Phe Met His Leu Cys Ile 
        435                 440                 445             


Gln Glu Phe Cys Ala Ala Met Phe Tyr Leu Leu Lys Arg Pro Lys Asp 
    450                 455                 460                 


Asp Pro Asn Pro Ala Ile Gly Ser Ile Thr Gln Leu Val Arg Ala Ser 
465                 470                 475                 480 


Val Val Gln Pro Gln Thr Leu Leu Thr Gln Val Gly Ile Phe Met Phe 
                485                 490                 495     


Gly Ile Ser Thr Glu Glu Ile Val Ser Met Leu Glu Thr Ser Phe Gly 
            500                 505                 510         


Phe Pro Leu Ser Lys Asp Leu Lys Gln Glu Ile Thr Gln Cys Leu Glu 
        515                 520                 525             


Ser Leu Ser Gln Cys Glu Ala Asp Arg Glu Ala Ile Ala Phe Gln Glu 
    530                 535                 540                 


Leu Phe Ile Gly Leu Phe Glu Thr Gln Glu Lys Glu Phe Val Thr Lys 
545                 550                 555                 560 


Val Met Asn Phe Phe Glu Glu Val Phe Ile Tyr Ile Gly Asn Ile Glu 
                565                 570                 575     


His Leu Val Ile Ala Ser Phe Cys Leu Lys His Cys Gln His Leu Thr 
            580                 585                 590         


Thr Leu Arg Met Cys Val Glu Asn Ile Phe Pro Asp Asp Ser Gly Cys 
        595                 600                 605             


Ile Ser Asp Tyr Asn Glu Lys Leu Val Tyr Trp Arg Glu Leu Cys Ser 
    610                 615                 620                 


Met Phe Ile Thr Asn Lys Asn Phe Gln Ile Leu Asp Met Glu Asn Thr 
625                 630                 635                 640 


Ser Leu Asp Asp Pro Ser Leu Ala Ile Leu Cys Lys Ala Leu Ala Gln 
                645                 650                 655     


Pro Val Cys Lys Leu Arg Lys Leu Ile Phe Thr Ser Val Tyr Phe Gly 
            660                 665                 670         


His Asp Ser Glu Leu Phe Lys Ala Val Leu His Asn Pro His Leu Lys 
        675                 680                 685             


Leu Leu Ser Leu Tyr Gly Thr Ser Leu Ser Gln Ser Asp Ile Arg His 
    690                 695                 700                 


Leu Cys Glu Thr Leu Lys His Pro Met Cys Lys Ile Glu Glu Leu Ile 
705                 710                 715                 720 


Leu Gly Lys Cys Asp Ile Ser Ser Glu Val Cys Glu Asp Ile Ala Ser 
                725                 730                 735     


Val Leu Ala Cys Asn Ser Lys Leu Lys His Leu Ser Leu Val Glu Asn 
            740                 745                 750         


Pro Leu Arg Asp Glu Gly Met Thr Leu Leu Cys Glu Ala Leu Lys His 
        755                 760                 765             


Ser His Cys Ala Leu Glu Arg Leu Met Leu Met Tyr Cys Cys Leu Thr 
    770                 775                 780                 


Ser Val Ser Cys Asp Ser Ile Ser Glu Val Leu Leu Cys Ser Lys Ser 
785                 790                 795                 800 


Leu Ser Leu Leu Asp Leu Gly Ser Asn Ala Leu Glu Asp Asn Gly Val 
                805                 810                 815     


Ala Ser Leu Cys Ala Ala Leu Lys His Pro Gly Cys Ser Ile Arg Glu 
            820                 825                 830         


Leu Trp Leu Met Gly Cys Phe Leu Thr Ser Asp Ser Cys Lys Asp Ile 
        835                 840                 845             


Ala Ala Val Leu Ile Cys Asn Gly Lys Leu Lys Thr Leu Lys Leu Gly 
    850                 855                 860                 


His Asn Glu Ile Gly Asp Thr Gly Val Arg Gln Leu Cys Ala Ala Leu 
865                 870                 875                 880 


Gln His Pro His Cys Lys Leu Glu Cys Leu Gly Leu Gln Thr Cys Pro 
                885                 890                 895     


Ile Thr Arg Ala Cys Cys Asp Asp Ile Ala Ala Ala Leu Ile Ala Cys 
            900                 905                 910         


Lys Thr Leu Arg Ser Leu Asn Leu Asp Trp Ile Ala Leu Asp Ala Asp 
        915                 920                 925             


Ala Val Val Val Leu Cys Glu Ala Leu Ser His Pro Asp Cys Ala Leu 
    930                 935                 940                 


Gln Met Leu Gly Asn Cys Gln Lys Ser Leu Gly Asp Thr Val Ala Pro 
945                 950                 955                 960 


Gly Glu Asn His Cys Ser Ile Lys His Leu Leu Leu Thr Leu Pro Ile 
                965                 970                 975     


Asn Met Gln Arg Gln Leu Arg Leu Gln Lys 
            980                 985     


<210> 5575
<211> 1012
<212> PRT
<213> Homo sapiens

<400> 5575
Met Asp Ala Leu Asp Ala Ser Lys Leu Leu Asp Glu Glu Leu Tyr Ser 
1               5                   10                  15      


Arg Gln Leu Tyr Val Leu Gly Ser Pro Ala Met Gln Arg Ile Gln Gly 
            20                  25                  30          


Ala Arg Val Leu Val Ser Gly Leu Gln Gly Leu Gly Ala Glu Val Ala 
        35                  40                  45              


Lys Asn Leu Val Leu Met Gly Val Gly Ser Leu Thr Leu His Asp Pro 
    50                  55                  60                  


His Pro Thr Cys Trp Ser Asp Leu Ala Ala Gln Phe Leu Leu Ser Glu 
65                  70                  75                  80  


Gln Asp Leu Glu Arg Ser Arg Ala Glu Ala Ser Gln Glu Leu Leu Ala 
                85                  90                  95      


Gln Leu Asn Arg Ala Val Gln Val Val Val His Thr Gly Asp Ile Thr 
            100                 105                 110         


Glu Asp Leu Leu Leu Asp Phe Gln Val Val Val Leu Thr Ala Ala Lys 
        115                 120                 125             


Leu Glu Glu Gln Leu Lys Val Gly Thr Leu Cys His Lys His Gly Val 
    130                 135                 140                 


Cys Phe Leu Ala Ala Asp Thr Arg Gly Leu Val Gly Gln Leu Phe Cys 
145                 150                 155                 160 


Asp Phe Gly Glu Asp Phe Thr Val Gln Asp Pro Thr Glu Ala Glu Pro 
                165                 170                 175     


Leu Thr Ala Ala Ile Gln His Ile Ser Gln Gly Ser Pro Gly Ile Leu 
            180                 185                 190         


Thr Leu Arg Lys Gly Ala Asn Thr His Tyr Phe Arg Asp Gly Asp Leu 
        195                 200                 205             


Val Thr Phe Ser Gly Ile Glu Gly Met Val Glu Leu Asn Asp Cys Asp 
    210                 215                 220                 


Pro Arg Ser Ile His Val Arg Glu Asp Gly Ser Leu Glu Ile Gly Asp 
225                 230                 235                 240 


Thr Thr Thr Phe Ser Arg Tyr Leu Arg Gly Gly Ala Ile Thr Glu Val 
                245                 250                 255     


Lys Arg Pro Lys Thr Val Arg His Lys Ser Leu Asp Thr Ala Leu Leu 
            260                 265                 270         


Gln Pro His Val Val Ala Gln Ser Ser Gln Glu Val His His Ala His 
        275                 280                 285             


Cys Leu His Gln Ala Phe Cys Ala Leu His Lys Phe Gln His Leu His 
    290                 295                 300                 


Gly Arg Pro Pro Gln Pro Trp Asp Pro Val Asp Ala Glu Thr Val Val 
305                 310                 315                 320 


Gly Leu Ala Arg Asp Leu Glu Pro Leu Lys Arg Thr Glu Glu Glu Pro 
                325                 330                 335     


Leu Glu Glu Pro Leu Asp Glu Ala Leu Val Arg Thr Val Ala Leu Ser 
            340                 345                 350         


Ser Ala Gly Val Leu Ser Pro Met Val Ala Met Leu Gly Ala Val Ala 
        355                 360                 365             


Ala Gln Glu Val Leu Lys Ala Ile Ser Arg Lys Phe Met Pro Leu Asp 
    370                 375                 380                 


Gln Trp Leu Tyr Phe Asp Ala Leu Asp Cys Leu Pro Glu Asp Gly Glu 
385                 390                 395                 400 


Leu Leu Pro Ser Pro Glu Asp Cys Ala Leu Arg Gly Ser Arg Tyr Asp 
                405                 410                 415     


Gly Gln Ile Ala Val Phe Gly Ala Gly Phe Gln Glu Lys Leu Arg Arg 
            420                 425                 430         


Gln His Tyr Leu Leu Val Gly Ala Gly Ala Ile Gly Cys Glu Leu Leu 
        435                 440                 445             


Lys Val Phe Ala Leu Val Gly Leu Gly Ala Gly Asn Ser Gly Gly Leu 
    450                 455                 460                 


Thr Val Val Asp Met Asp His Ile Glu Arg Ser Asn Leu Ser Arg Gln 
465                 470                 475                 480 


Phe Leu Phe Arg Ser Gln Asp Val Gly Arg Pro Lys Ala Glu Val Ala 
                485                 490                 495     


Ala Ala Ala Ala Arg Gly Leu Asn Pro Asp Leu Gln Val Ile Pro Leu 
            500                 505                 510         


Thr Tyr Pro Leu Asp Pro Thr Thr Glu His Ile Tyr Gly Asp Asn Phe 
        515                 520                 525             


Phe Ser Arg Val Asp Gly Val Ala Ala Ala Leu Asp Ser Phe Gln Ala 
    530                 535                 540                 


Arg Arg Tyr Val Ala Ala Arg Cys Thr His Tyr Leu Lys Pro Leu Leu 
545                 550                 555                 560 


Glu Ala Gly Thr Ser Gly Thr Trp Gly Ser Ala Thr Val Phe Met Pro 
                565                 570                 575     


His Val Thr Glu Ala Tyr Arg Ala Pro Ala Ser Ala Ala Ala Ser Glu 
            580                 585                 590         


Asp Ala Pro Tyr Pro Val Cys Thr Val Arg Tyr Phe Pro Ser Thr Ala 
        595                 600                 605             


Glu His Thr Leu Gln Trp Ala Arg His Glu Phe Glu Glu Leu Phe Arg 
    610                 615                 620                 


Leu Ser Ala Glu Thr Ile Asn His His Gln Gln Ala His Thr Ser Leu 
625                 630                 635                 640 


Ala Asp Met Asp Glu Pro Gln Thr Leu Thr Leu Leu Lys Pro Val Leu 
                645                 650                 655     


Gly Val Leu Arg Val Arg Pro Gln Asn Trp Gln Asp Cys Val Ala Trp 
            660                 665                 670         


Ala Leu Gly His Trp Lys Leu Cys Phe His Tyr Gly Ile Lys Gln Leu 
        675                 680                 685             


Leu Arg His Phe Pro Pro Asn Lys Val Leu Glu Asp Gly Thr Pro Phe 
    690                 695                 700                 


Trp Ser Gly Pro Lys Gln Cys Pro Gln Pro Leu Glu Phe Asp Thr Asn 
705                 710                 715                 720 


Gln Asp Thr His Leu Leu Tyr Val Leu Ala Ala Ala Asn Leu Tyr Ala 
                725                 730                 735     


Gln Met His Gly Leu Pro Gly Ser Gln Asp Trp Thr Ala Leu Arg Glu 
            740                 745                 750         


Leu Leu Lys Leu Leu Pro Gln Pro Asp Pro Gln Gln Met Ala Pro Ile 
        755                 760                 765             


Phe Ala Ser Asn Leu Glu Leu Ala Ser Ala Ser Ala Glu Phe Gly Pro 
    770                 775                 780                 


Glu Gln Gln Lys Glu Leu Asn Lys Ala Leu Glu Val Trp Ser Val Gly 
785                 790                 795                 800 


Pro Pro Leu Lys Pro Leu Met Phe Glu Lys Asp Asp Asp Ser Asn Phe 
                805                 810                 815     


His Val Asp Phe Val Val Ala Ala Ala Ser Leu Arg Cys Gln Asn Tyr 
            820                 825                 830         


Gly Ile Pro Pro Val Asn Arg Ala Gln Ser Lys Arg Ile Val Gly Gln 
        835                 840                 845             


Ile Ile Pro Ala Ile Ala Thr Thr Thr Ala Ala Val Ala Gly Leu Leu 
    850                 855                 860                 


Gly Leu Glu Leu Tyr Lys Val Val Ser Gly Pro Arg Pro Arg Ser Ala 
865                 870                 875                 880 


Phe Arg His Ser Tyr Leu His Leu Ala Glu Asn Tyr Leu Ile Arg Tyr 
                885                 890                 895     


Met Pro Phe Ala Pro Ala Ile Gln Thr Phe His His Leu Lys Trp Thr 
            900                 905                 910         


Ser Trp Asp Arg Leu Lys Val Pro Ala Gly Gln Pro Glu Arg Thr Leu 
        915                 920                 925             


Glu Ser Leu Leu Ala His Leu Gln Glu Gln His Gly Leu Arg Val Arg 
    930                 935                 940                 


Ile Leu Leu His Gly Ser Ala Leu Leu Tyr Ala Ala Gly Trp Ser Pro 
945                 950                 955                 960 


Glu Lys Gln Ala Gln His Leu Pro Leu Arg Val Thr Glu Leu Val Gln 
                965                 970                 975     


Gln Leu Thr Gly Gln Ala Pro Ala Pro Gly Gln Arg Val Leu Val Leu 
            980                 985                 990         


Glu Leu Ser Cys Glu Gly Asp Asp  Glu Asp Thr Ala Phe  Pro Pro Leu 
        995                 1000                 1005             


His Tyr  Glu Leu 
    1010         


<210> 5576
<211> 119
<212> PRT
<213> Homo sapiens

<400> 5576
Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Val Glu Ser Lys Asn Val Ala Leu Pro Lys Gly Thr 
    50                  55                  60                  


Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile Ser Asp Gly 
65                  70                  75                  80  


Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr Ile Pro Leu 
                85                  90                  95      


Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr Ala Tyr Phe 
            100                 105                 110         


Gly Leu Leu Glu Ile Cys Gly 
        115                 


<210> 5577
<211> 598
<212> PRT
<213> Homo sapiens

<400> 5577
Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu 
1               5                   10                  15      


Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser 
            20                  25                  30          


Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His 
        35                  40                  45              


Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro 
    50                  55                  60                  


Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn 
65                  70                  75                  80  


Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val 
                85                  90                  95      


Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr 
            100                 105                 110         


Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys 
        115                 120                 125             


Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp 
    130                 135                 140                 


Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys 
145                 150                 155                 160 


Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg 
                165                 170                 175     


Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser 
            180                 185                 190         


Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val 
        195                 200                 205             


Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu 
    210                 215                 220                 


Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys 
225                 230                 235                 240 


Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe 
                245                 250                 255     


Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr 
            260                 265                 270         


Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu 
        275                 280                 285             


Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu 
    290                 295                 300                 


Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro 
305                 310                 315                 320 


Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val 
                325                 330                 335     


Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr 
            340                 345                 350         


Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe 
        355                 360                 365             


Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe 
    370                 375                 380                 


Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu 
385                 390                 395                 400 


Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys 
                405                 410                 415     


Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala 
            420                 425                 430         


Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe 
        435                 440                 445             


Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala 
    450                 455                 460                 


Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys 
465                 470                 475                 480 


Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala 
                485                 490                 495     


Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr 
            500                 505                 510         


Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly 
        515                 520                 525             


Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys 
    530                 535                 540                 


Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser 
545                 550                 555                 560 


Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser 
                565                 570                 575     


Gly Arg Ala Ile Arg Lys Arg Glu Val Glu Thr Gly Asp Met Ser Trp 
            580                 585                 590         


Leu Thr Gly Lys Gly Ser 
        595             


<210> 5578
<211> 617
<212> PRT
<213> Homo sapiens

<400> 5578
Met Gly Ser Tyr Leu Ser Val Pro Ala Tyr Phe Thr Ser Arg Asp Leu 
1               5                   10                  15      


Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr Asn Trp Tyr Tyr Glu 
            20                  25                  30          


Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr Trp Gly Lys Phe Gly 
        35                  40                  45              


Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr Gly Pro Phe Met Val 
    50                  55                  60                  


Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe Ala Cys Met Ser Cys 
65                  70                  75                  80  


Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala Leu Val Gln His Ala 
                85                  90                  95      


Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val Val Leu Ala Pro Met 
            100                 105                 110         


Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu Gln Leu Pro Tyr Ser 
        115                 120                 125             


Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu Gly Arg Arg Gly Phe 
    130                 135                 140                 


Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr Ala Thr Thr Val Gln 
145                 150                 155                 160 


Val Lys Glu Val Asn Arg Met His Ile Ser Pro Asn Asn Arg Asn Ala 
                165                 170                 175     


Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn Gly Thr Pro Val Arg 
            180                 185                 190         


Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile Ser Gln Thr Ser Gln 
        195                 200                 205             


Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val Ser Gln Arg Leu Asp 
    210                 215                 220                 


Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His Met Gln Asn Ala Gly 
225                 230                 235                 240 


His Pro His Ala Leu Ser Thr Leu Asp Thr Lys Glu Asn Leu Glu Gly 
                245                 250                 255     


Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn Ser Ile Ser Lys Ser 
            260                 265                 270         


Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu Phe Ser Arg Asp Ile 
        275                 280                 285             


Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser Tyr Ser Gln Gln Ile 
    290                 295                 300                 


Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Phe 
305                 310                 315                 320 


Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala Thr Gly Lys Val Met 
                325                 330                 335     


Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu Thr Gln Lys Thr Phe 
            340                 345                 350         


Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp His Pro Asn Val Leu 
        355                 360                 365             


Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys Leu Asn Leu Leu Thr 
    370                 375                 380                 


Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe Leu Arg Ser Met Asp 
385                 390                 395                 400 


Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala Lys Gly Ile Ala Ser 
                405                 410                 415     


Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile His Arg Asp Leu Asn 
            420                 425                 430         


Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr Val Val Val Ala Asp 
        435                 440                 445             


Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg Lys Arg Ala Pro Met 
    450                 455                 460                 


Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg Lys Asn Asp Arg Lys 
465                 470                 475                 480 


Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp Met Ala Pro Glu Met 
                485                 490                 495     


Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp Ile Phe Ser Phe Gly 
            500                 505                 510         


Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr Ala Asp Pro Asp Cys 
        515                 520                 525             


Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val Lys Leu Phe Trp Glu 
    530                 535                 540                 


Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe Phe Pro Leu Ala Ala 
545                 550                 555                 560 


Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Pro Ala Phe Ser Lys Leu 
                565                 570                 575     


Glu Asp Ser Phe Glu Ala Leu Ser Leu Tyr Leu Gly Glu Leu Gly Ile 
            580                 585                 590         


Pro Leu Pro Ala Glu Leu Glu Glu Leu Asp His Thr Val Ser Met Gln 
        595                 600                 605             


Tyr Gly Leu Thr Arg Asp Ser Pro Pro 
    610                 615         


<210> 5579
<211> 445
<212> PRT
<213> Homo sapiens

<400> 5579
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ala Gly Asn Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ser Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Ser Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ser Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Ile Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asp Glu 
            420                 425                 430         


Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp Glu Ala 
        435                 440                 445 


<210> 5580
<211> 675
<212> PRT
<213> Homo sapiens

<400> 5580
Met Ala Lys His Gly Ala Asp Glu Pro Ser Ser Arg Ser Gly Ser Pro 
1               5                   10                  15      


Asp Arg Glu Gly Arg Ala Ser Glu Asp Arg Ser Leu Leu His Gln Arg 
            20                  25                  30          


Leu Ala Val Arg Glu Leu Ile Asp Thr Glu Val Ser Tyr Leu His Met 
        35                  40                  45              


Leu Gln Leu Cys Ala Ser Asp Ile Arg Ser Arg Leu Gln Gln Leu Pro 
    50                  55                  60                  


Gln Gly Asp Leu Asp Val Leu Phe Ser Asn Ile Asp Asp Ile Ile Lys 
65                  70                  75                  80  


Val Asn Ser Arg Phe Leu His Asp Leu Gln Glu Thr Ala Ser Lys Glu 
                85                  90                  95      


Glu Glu Gln Val Gln Leu Val Gly Asn Ile Phe Leu Glu Phe Gln Glu 
            100                 105                 110         


Glu Leu Glu Gln Val Tyr Lys Val Tyr Cys Ala Ser Tyr Asp Gln Ala 
        115                 120                 125             


Leu Leu Leu Val Asp Thr Tyr Arg Lys Glu Pro Glu Leu Gln Arg His 
    130                 135                 140                 


Ile Gln Gly Ile Val Glu Ala Val Val Pro Gln Ala Gly Ser Ser Gly 
145                 150                 155                 160 


Leu Ser Phe Leu Leu Val Ile Pro Leu Gln Arg Ile Thr Arg Tyr Pro 
                165                 170                 175     


Leu Leu Leu Gln Lys Ile Leu Glu Asn Thr Val Pro Asp Ala Ser Ala 
            180                 185                 190         


Tyr Pro Val Leu Gln Arg Ala Val Ser Ala Leu Gln Asp Val Asn Thr 
        195                 200                 205             


Asn Ile Asn Glu Tyr Lys Met Arg Lys Glu Val Ala Ser Lys Tyr Thr 
    210                 215                 220                 


Lys Val Glu Gln Leu Thr Leu Arg Glu Arg Leu Ala Arg Ile Asn Thr 
225                 230                 235                 240 


His Thr Leu Ser Lys Lys Thr Thr Arg Leu Ser Gln Leu Leu Lys Gln 
                245                 250                 255     


Glu Ala Gly Leu Ile Pro Arg Thr Glu Asp Lys Glu Phe Asp Asp Leu 
            260                 265                 270         


Glu Glu Arg Phe Gln Trp Val Ser Leu Cys Val Thr Glu Leu Lys Asn 
        275                 280                 285             


Asn Val Ala Ala Tyr Leu Asp Asn Leu Gln Ala Phe Leu Tyr Phe Arg 
    290                 295                 300                 


Pro His Glu Tyr Asn Leu Asp Ile Pro Glu Gly Pro Ala Val Gln Tyr 
305                 310                 315                 320 


Cys Asn Leu Ala Arg Asp Leu His Leu Glu Ala Phe Leu Lys Phe Lys 
                325                 330                 335     


Gln Arg Leu Glu Gly Leu Val Trp Gln Pro Leu Cys Ser Leu Ala Lys 
            340                 345                 350         


Ala Leu Leu Gly Pro Gln Asn Leu Ile Lys Lys Arg Leu Asp Lys Leu 
        355                 360                 365             


Leu Asp Phe Glu Arg Val Glu Glu Lys Leu Leu Glu Val Gly Ser Val 
    370                 375                 380                 


Thr Tyr Gln Glu Glu Ala Ala Arg His Thr Tyr Gln Ala Leu Asn Ser 
385                 390                 395                 400 


Leu Leu Val Ala Glu Leu Pro Gln Phe Asn Gln Leu Val Met Gln Trp 
                405                 410                 415     


Leu Gly Gln Ile Met Cys Thr Phe Val Thr Leu Gln Arg Asp Leu Ala 
            420                 425                 430         


Lys Gln Val Leu Gln Arg Ala Glu Gly Ser Met Ala Gln Leu Pro His 
        435                 440                 445             


His His Val Pro Glu Pro Ala Phe Arg Lys Leu Val Glu Asp Ala Leu 
    450                 455                 460                 


Gly Arg Thr Ser Asn Gln Leu Arg Ser Phe Gln Glu Thr Phe Glu Lys 
465                 470                 475                 480 


Val Gln Pro Pro Pro Thr Thr Gln Pro Leu Leu Pro Gly Ser Glu Arg 
                485                 490                 495     


Gln Val Gln Ala Leu Leu Ser Arg Tyr Gly Pro Gly Lys Leu Tyr Gln 
            500                 505                 510         


Val Thr Ser Asn Ile Ser Gly Thr Gly Thr Leu Asp Leu Thr Leu Pro 
        515                 520                 525             


Arg Gly Gln Ile Val Ala Ile Leu Gln Asn Lys Asp Thr Lys Gly Asn 
    530                 535                 540                 


Ser Gly Arg Trp Leu Val Asp Thr Gly Gly His Arg Gly Tyr Val Pro 
545                 550                 555                 560 


Ala Gly Lys Leu Gln Leu Tyr His Val Val Pro Ser Ala Glu Glu Leu 
                565                 570                 575     


Arg Arg Gln Ala Gly Leu Asn Lys Asp Pro Arg Cys Leu Thr Pro Glu 
            580                 585                 590         


Pro Ser Pro Ala Leu Val Pro Ser Ile Pro Thr Met Asn Gln Val Ile 
        595                 600                 605             


Ala Ala Tyr Pro Phe Val Ala Arg Ser Ser His Glu Val Ser Leu Gln 
    610                 615                 620                 


Ala Gly Gln Pro Val Thr Ile Leu Glu Ala Gln Asp Lys Lys Gly Asn 
625                 630                 635                 640 


Pro Glu Trp Ser Leu Val Glu Val Asn Gly Gln Arg Gly Tyr Val Pro 
                645                 650                 655     


Ser Gly Phe Leu Ala Arg Ala Arg Ser Pro Val Leu Trp Gly Trp Ser 
            660                 665                 670         


Leu Pro Ser 
        675 


<210> 5581
<211> 1132
<212> PRT
<213> Homo sapiens

<400> 5581
Met Ala Ser Asp Gly Ala Ser Ala Leu Pro Gly Pro Asp Met Ser Met 
1               5                   10                  15      


Lys Pro Ser Ala Ala Pro Ser Pro Ser Pro Ala Leu Pro Phe Leu Pro 
            20                  25                  30          


Pro Thr Ser Asp Pro Pro Asp His Pro Pro Arg Glu Pro Pro Pro Gln 
        35                  40                  45              


Pro Ile Met Pro Ser Val Phe Ser Pro Asp Asn Pro Leu Met Leu Ser 
    50                  55                  60                  


Ala Phe Pro Ser Ser Leu Leu Val Thr Gly Asp Gly Gly Pro Cys Leu 
65                  70                  75                  80  


Ser Gly Ala Gly Ala Gly Lys Val Ile Val Lys Val Lys Thr Glu Gly 
                85                  90                  95      


Gly Ser Ala Glu Pro Ser Gln Thr Gln Asn Phe Ile Leu Thr Gln Thr 
            100                 105                 110         


Ala Leu Asn Ser Thr Ala Pro Gly Thr Pro Cys Gly Gly Leu Glu Gly 
        115                 120                 125             


Pro Ala Pro Pro Phe Val Thr Ala Ser Asn Val Lys Thr Ile Leu Pro 
    130                 135                 140                 


Ser Lys Ala Val Gly Val Ser Gln Glu Gly Pro Pro Gly Leu Pro Pro 
145                 150                 155                 160 


Gln Pro Pro Pro Pro Val Ala Gln Leu Val Pro Ile Val Pro Leu Glu 
                165                 170                 175     


Lys Ala Trp Pro Gly Pro His Gly Thr Thr Gly Glu Gly Gly Pro Val 
            180                 185                 190         


Ala Thr Leu Ser Lys Pro Ser Leu Gly Asp Arg Ser Lys Ile Ser Lys 
        195                 200                 205             


Asp Val Tyr Glu Asn Phe Arg Gln Trp Gln Arg Tyr Lys Ala Leu Ala 
    210                 215                 220                 


Arg Arg His Leu Ser Gln Ser Pro Asp Thr Glu Ala Leu Ser Cys Phe 
225                 230                 235                 240 


Leu Ile Pro Val Leu Arg Ser Leu Ala Arg Leu Lys Pro Thr Met Thr 
                245                 250                 255     


Leu Glu Glu Gly Leu Pro Leu Ala Val Gln Glu Trp Glu His Thr Ser 
            260                 265                 270         


Asn Phe Asp Arg Met Ile Phe Tyr Glu Met Ala Glu Arg Phe Met Glu 
        275                 280                 285             


Phe Glu Ala Glu Glu Met Gln Ile Gln Asn Thr Gln Leu Met Asn Gly 
    290                 295                 300                 


Ser Gln Gly Leu Ser Pro Ala Thr Pro Leu Lys Leu Asp Pro Leu Gly 
305                 310                 315                 320 


Pro Leu Ala Ser Glu Val Cys Gln Gln Pro Val Tyr Ile Pro Lys Lys 
                325                 330                 335     


Ala Ala Ser Lys Thr Arg Ala Pro Arg Arg Arg Gln Arg Lys Ala Gln 
            340                 345                 350         


Arg Pro Pro Ala Pro Glu Ala Pro Lys Glu Ile Pro Pro Glu Ala Val 
        355                 360                 365             


Lys Glu Tyr Val Asp Ile Met Glu Trp Leu Val Gly Thr His Leu Ala 
    370                 375                 380                 


Thr Gly Glu Ser Asp Gly Lys Gln Glu Glu Glu Gly Gln Gln Gln Glu 
385                 390                 395                 400 


Glu Glu Gly Met Tyr Pro Asp Pro Gly Leu Leu Ser Tyr Ile Asn Glu 
                405                 410                 415     


Leu Cys Ser Gln Lys Val Phe Val Ser Lys Val Glu Ala Val Ile His 
            420                 425                 430         


Pro Gln Phe Leu Ala Asp Leu Leu Ser Pro Glu Lys Gln Arg Asp Pro 
        435                 440                 445             


Leu Ala Leu Ile Glu Glu Leu Glu Gln Glu Glu Gly Leu Thr Leu Ala 
    450                 455                 460                 


Gln Leu Val Gln Lys Arg Leu Met Ala Leu Glu Glu Glu Glu Asp Ala 
465                 470                 475                 480 


Glu Ala Pro Pro Ser Phe Ser Gly Ala Gln Leu Asp Ser Ser Pro Ser 
                485                 490                 495     


Gly Ser Val Glu Asp Glu Asp Gly Asp Gly Arg Leu Arg Pro Ser Pro 
            500                 505                 510         


Gly Leu Gln Gly Ala Gly Gly Ala Ala Cys Leu Gly Lys Val Ser Ser 
        515                 520                 525             


Ser Gly Lys Arg Ala Arg Glu Val His Gly Gly Gln Glu Gln Ala Leu 
    530                 535                 540                 


Asp Ser Pro Arg Gly Met His Arg Asp Gly Asn Thr Leu Pro Ser Pro 
545                 550                 555                 560 


Ser Ser Trp Asp Leu Gln Pro Glu Leu Ala Ala Pro Gln Gly Thr Pro 
                565                 570                 575     


Gly Pro Leu Gly Val Glu Arg Arg Gly Ser Gly Lys Val Ile Asn Gln 
            580                 585                 590         


Val Ser Leu His Gln Asp Gly His Leu Gly Gly Ala Gly Pro Pro Gly 
        595                 600                 605             


His Cys Leu Val Ala Asp Arg Thr Ser Glu Ala Leu Pro Leu Cys Trp 
    610                 615                 620                 


Gln Gly Gly Phe Gln Pro Glu Ser Thr Pro Ser Leu Asp Ala Gly Leu 
625                 630                 635                 640 


Ala Glu Leu Ala Pro Leu Gln Gly Gln Gly Leu Glu Lys Gln Val Leu 
                645                 650                 655     


Gly Leu Gln Lys Gly Gln Gln Thr Gly Gly Arg Gly Val Leu Pro Gln 
            660                 665                 670         


Gly Lys Glu Pro Leu Ala Val Pro Trp Glu Gly Ser Ser Gly Ala Met 
        675                 680                 685             


Trp Gly Asp Asp Arg Gly Thr Pro Met Ala Gln Ser Tyr Asp Gln Asn 
    690                 695                 700                 


Pro Ser Pro Arg Ala Ala Gly Glu Arg Asp Asp Val Cys Leu Ser Pro 
705                 710                 715                 720 


Gly Val Trp Leu Ser Ser Glu Met Asp Ala Val Gly Leu Glu Leu Pro 
                725                 730                 735     


Val Gln Ile Glu Glu Val Ile Glu Ser Phe Gln Val Glu Lys Cys Val 
            740                 745                 750         


Thr Glu Tyr Gln Glu Gly Cys Gln Gly Leu Gly Ser Arg Gly Asn Ile 
        755                 760                 765             


Ser Leu Gly Pro Gly Glu Thr Leu Val Pro Gly Asp Thr Glu Ser Ser 
    770                 775                 780                 


Val Ile Pro Cys Gly Gly Thr Val Ala Ala Ala Ala Leu Glu Lys Arg 
785                 790                 795                 800 


Asn Tyr Cys Ser Leu Pro Gly Pro Leu Arg Ala Asn Ser Pro Pro Leu 
                805                 810                 815     


Arg Ser Lys Glu Asn Gln Glu Gln Ser Cys Glu Thr Val Gly His Pro 
            820                 825                 830         


Ser Asp Leu Trp Ala Glu Gly Cys Phe Pro Leu Leu Glu Ser Gly Asp 
        835                 840                 845             


Ser Thr Leu Gly Ser Ser Lys Glu Thr Leu Pro Pro Thr Cys Gln Gly 
    850                 855                 860                 


Asn Leu Leu Ile Met Gly Thr Glu Asp Ala Ser Ser Leu Pro Glu Ala 
865                 870                 875                 880 


Ser Gln Glu Ala Gly Ser Arg Gly Asn Ser Phe Ser Pro Leu Leu Glu 
                885                 890                 895     


Thr Ile Glu Pro Val Asn Ile Leu Asp Val Lys Asp Asp Cys Gly Leu 
            900                 905                 910         


Gln Leu Arg Val Ser Glu Asp Thr Cys Pro Leu Asn Val His Ser Tyr 
        915                 920                 925             


Asp Pro Gln Gly Glu Gly Arg Val Asp Pro Asp Leu Ser Lys Pro Lys 
    930                 935                 940                 


Asn Leu Ala Pro Leu Gln Glu Ser Gln Glu Ser Tyr Thr Thr Gly Thr 
945                 950                 955                 960 


Pro Lys Ala Thr Ser Ser His Gln Gly Leu Gly Ser Thr Leu Pro Arg 
                965                 970                 975     


Arg Gly Thr Arg Asn Ala Ile Val Pro Arg Glu Thr Ser Val Ser Lys 
            980                 985                 990         


Thr His Arg Ser Ala Asp Arg Ala  Lys Gly Lys Glu Lys  Lys Lys Lys 
        995                 1000                 1005             


Glu Ala  Glu Glu Glu Asp Glu  Glu Leu Ser Asn Phe  Ala Tyr Leu 
    1010                 1015                 1020             


Leu Ala  Ser Lys Leu Ser Leu  Ser Pro Arg Glu His  Pro Leu Ser 
    1025                 1030                 1035             


Pro His  His Ala Ser Gly Gly  Gln Gly Ser Gln Arg  Ala Ser His 
    1040                 1045                 1050             


Leu Leu  Pro Ala Gly Ala Lys  Gly Pro Ser Lys Leu  Pro Tyr Pro 
    1055                 1060                 1065             


Val Ala  Lys Ser Gly Lys Arg  Ala Leu Ala Gly Gly  Pro Ala Pro 
    1070                 1075                 1080             


Thr Glu  Lys Thr Pro His Ser  Gly Ala Gln Leu Gly  Val Pro Arg 
    1085                 1090                 1095             


Glu Lys  Pro Leu Ala Leu Gly  Val Val Arg Pro Ser  Gln Pro Arg 
    1100                 1105                 1110             


Lys Arg  Arg Cys Asp Ser Phe  Val Thr Gly Arg Arg  Lys Lys Arg 
    1115                 1120                 1125             


Arg Arg  Ser Gln 
    1130         


<210> 5582
<211> 173
<212> PRT
<213> Homo sapiens

<400> 5582
Met Ala Val Ala Val Gly Val Arg Ala Ala Pro Val Leu Gly Leu Ala 
1               5                   10                  15      


Arg Ala Leu Val Leu Gly Leu Arg Gly Ser Gln Ala Ala Arg Trp Arg 
            20                  25                  30          


Gly Trp Gly Thr Ala Ala Pro Gly Ser Leu Trp Ala Leu Cys Glu Cys 
        35                  40                  45              


Pro Ala Gly Cys Arg Glu Leu Trp Phe Arg Gly Arg Ala Ala Trp Ala 
    50                  55                  60                  


Ala Arg Ser Glu Arg Leu Leu His Pro Ala Gln Asp Ser Asp Gly Glu 
65                  70                  75                  80  


Arg Glu Asp Ser Ala Ala Glu Arg Ala Arg Gln Gln Leu Glu Ala Leu 
                85                  90                  95      


Leu Asn Lys Thr Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val 
            100                 105                 110         


Gly Cys Phe Leu Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser 
        115                 120                 125             


Ala Gln Glu Phe Leu Lys Pro Ser Asp Ser Phe Ser Ala Gly Glu Pro 
    130                 135                 140                 


Arg Val Leu Gly Leu Ala Met Val Pro Gly His His Ile Val Ser Ile 
145                 150                 155                 160 


Glu Val Gln Arg Glu Ser Leu Thr Gly Pro Pro Tyr Leu 
                165                 170             


<210> 5583
<211> 185
<212> PRT
<213> Homo sapiens

<400> 5583
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Gln Asp Leu Cys Gln Glu Thr Cys Cys Cys Pro Ser Cys Cys Gln Thr 
            20                  25                  30          


Thr Cys Cys Arg Thr Thr Cys Tyr Arg Pro Ser Tyr Ser Val Ser Cys 
        35                  40                  45              


Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys 
    50                  55                  60                  


Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro Gln Cys Cys 
65                  70                  75                  80  


Gln Ser Val Cys Cys Gln Pro Thr Cys Cys His Pro Ser Cys Cys Ile 
                85                  90                  95      


Ser Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro 
            100                 105                 110         


Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Asn Cys Cys Arg Pro Ser 
        115                 120                 125             


Cys Ser Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys 
    130                 135                 140                 


Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly Arg Val Ser Cys 
145                 150                 155                 160 


His Thr Thr Cys Tyr Arg Pro Ala Cys Val Ile Ser Thr Cys Pro Arg 
                165                 170                 175     


Pro Val Cys Cys Ala Ser Ser Cys Cys 
            180                 185 


<210> 5584
<211> 83
<212> PRT
<213> Homo sapiens

<400> 5584
Met Cys Cys Asn Tyr Tyr Arg Asn Cys Cys Gly Gly Cys Gly Tyr Gly 
1               5                   10                  15      


Ser Gly Trp Ser Ser Gly Cys Gly Tyr Gly Cys Gly Tyr Gly Cys Gly 
            20                  25                  30          


Tyr Gly Ser Gly Cys Arg Tyr Gly Ser Gly Tyr Gly Thr Gly Cys Gly 
        35                  40                  45              


Tyr Gly Cys Gly Tyr Gly Ser Gly Cys Gly Tyr Gly Cys Gly Tyr Ser 
    50                  55                  60                  


Ser Ser Cys Cys Gly Tyr Arg Pro Leu Cys Tyr Arg Arg Cys Tyr Ser 
65                  70                  75                  80  


Ser Cys Tyr 
            


<210> 5585
<211> 330
<212> PRT
<213> Homo sapiens

<400> 5585
Met Gly Ser Arg Lys Lys Glu Ile Ala Leu Gln Val Asn Ile Ser Thr 
1               5                   10                  15      


Gln Glu Leu Trp Glu Glu Met Leu Ser Ser Lys Gly Leu Thr Val Val 
            20                  25                  30          


Asp Val Tyr Gln Gly Trp Cys Gly Pro Cys Lys Pro Val Val Ser Leu 
        35                  40                  45              


Phe Gln Lys Met Arg Ile Glu Val Gly Leu Asp Leu Leu His Phe Ala 
    50                  55                  60                  


Leu Ala Glu Ala Asp Arg Leu Asp Val Leu Glu Lys Tyr Arg Gly Lys 
65                  70                  75                  80  


Cys Glu Pro Thr Phe Leu Phe Tyr Ala Gly Gly Glu Leu Val Ala Val 
                85                  90                  95      


Val Arg Gly Ala Asn Ala Pro Leu Leu Gln Lys Thr Ile Leu Asp Gln 
            100                 105                 110         


Leu Glu Ala Glu Lys Lys Val Leu Ala Glu Gly Arg Glu Arg Lys Val 
        115                 120                 125             


Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val Ser His Gly 
    130                 135                 140                 


Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu Arg Thr Cys 
145                 150                 155                 160 


Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly Lys Thr Asp 
                165                 170                 175     


Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile Leu Thr Asn 
            180                 185                 190         


Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe Tyr Gln His 
        195                 200                 205             


Lys Ala Gly Glu Glu Ala Phe Glu Lys Leu Val His His Met Cys Ser 
    210                 215                 220                 


Gly Pro Ser His Leu Leu Ile Leu Thr Arg Thr Glu Gly Phe Glu Asp 
225                 230                 235                 240 


Val Val Thr Thr Trp Arg Thr Val Met Gly Pro Arg Asp Pro Asn Val 
                245                 250                 255     


Ala Arg Arg Glu Gln Pro Glu Ser Leu Arg Ala Gln Tyr Gly Thr Glu 
            260                 265                 270         


Met Pro Phe Asn Ala Val His Gly Ser Arg Asp Arg Glu Asp Ala Asp 
        275                 280                 285             


Arg Glu Leu Ala Leu Leu Phe Pro Ser Leu Lys Phe Ser Asp Lys Asp 
    290                 295                 300                 


Thr Glu Ala Pro Gln Gly Gly Glu Ala Glu Ala Thr Ala Gly Pro Thr 
305                 310                 315                 320 


Glu Ala Leu Cys Phe Pro Glu Asp Val Asp 
                325                 330 


<210> 5586
<211> 201
<212> PRT
<213> Homo sapiens

<400> 5586
Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Gln Asp Leu Cys Gln Glu Thr Cys Cys Arg Pro Ser Cys Cys Glu Thr 
            20                  25                  30          


Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser 
        35                  40                  45              


Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys 
    50                  55                  60                  


Ser Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Tyr 
65                  70                  75                  80  


Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln 
                85                  90                  95      


Pro Ala Cys Cys Gln Pro Thr Cys Cys Arg Pro Pro Arg Cys Cys Ile 
            100                 105                 110         


Ser Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro 
        115                 120                 125             


Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Asn Cys Cys Arg Pro Ser 
    130                 135                 140                 


Cys Ser Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys 
145                 150                 155                 160 


Cys Arg Pro Cys Cys Cys Val Arg Pro Val Cys Gly Arg Val Ser Cys 
                165                 170                 175     


His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser Ser Cys Pro Arg 
            180                 185                 190         


Pro Leu Cys Cys Ala Ser Ser Cys Cys 
        195                 200     


<210> 5587
<211> 263
<212> PRT
<213> Homo sapiens

<400> 5587
Met Gly Asp Ile Pro Ala Val Gly Leu Ser Ser Trp Lys Ala Ser Pro 
1               5                   10                  15      


Gly Lys Val Thr Glu Ala Val Lys Glu Ala Ile Asp Ala Gly Tyr Arg 
            20                  25                  30          


His Phe Asp Cys Ala Tyr Phe Tyr His Asn Glu Arg Glu Val Gly Ala 
        35                  40                  45              


Gly Ile Arg Cys Lys Ile Lys Glu Gly Ala Val Arg Arg Glu Asp Leu 
    50                  55                  60                  


Phe Ile Ala Thr Lys Leu Trp Cys Thr Cys His Lys Lys Ser Leu Val 
65                  70                  75                  80  


Glu Thr Ala Cys Arg Lys Ser Leu Lys Ala Leu Lys Leu Asn Tyr Leu 
                85                  90                  95      


Asp Leu Tyr Leu Ile His Trp Pro Met Gly Phe Lys Pro Pro His Pro 
            100                 105                 110         


Glu Trp Ile Met Ser Cys Ser Glu Leu Ser Phe Cys Leu Ser His Pro 
        115                 120                 125             


Arg Val Gln Asp Leu Pro Leu Asp Glu Ser Asn Met Val Ile Pro Ser 
    130                 135                 140                 


Asp Thr Asp Phe Leu Asp Thr Trp Glu Ala Met Glu Asp Leu Val Ile 
145                 150                 155                 160 


Thr Gly Leu Val Lys Asn Ile Gly Val Ser Asn Phe Asn His Glu Gln 
                165                 170                 175     


Leu Glu Arg Leu Leu Asn Lys Pro Gly Leu Arg Phe Lys Pro Leu Thr 
            180                 185                 190         


Asn Gln Ile Leu Ile Arg Phe Gln Ile Gln Arg Asn Val Ile Val Ile 
        195                 200                 205             


Pro Gly Ser Ile Thr Pro Ser His Ile Lys Glu Asn Ile Gln Val Phe 
    210                 215                 220                 


Asp Phe Glu Leu Thr Gln His Asp Met Asp Asn Ile Leu Ser Leu Asn 
225                 230                 235                 240 


Arg Asn Leu Arg Leu Ala Met Phe Pro Ile Thr Lys Asn His Lys Asp 
                245                 250                 255     


Tyr Pro Phe His Ile Glu Tyr 
            260             


<210> 5588
<211> 58
<212> PRT
<213> Homo sapiens

<400> 5588
Met Arg Tyr Tyr Gly Ser Tyr Tyr Arg Gly Leu Gly Tyr Gly Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Cys Gly Cys Gly Gly Tyr Arg Tyr 
            20                  25                  30          


Gly Ser Gly Tyr Gly Gly Tyr Arg Tyr Gly Cys Cys Arg Pro Ser Cys 
        35                  40                  45              


Arg Glu Gly Tyr Gly Phe Ser Gly Phe Tyr 
    50                  55              


<210> 5589
<211> 52
<212> PRT
<213> Homo sapiens

<400> 5589
Met Cys Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe Cys Arg Leu Gly 
1               5                   10                  15      


Tyr Gly Cys Gly Tyr Glu Gly Cys Arg Tyr Gly Cys Gly His Arg Gly 
            20                  25                  30          


Cys Gly Asp Gly Cys Cys Cys Pro Ser Cys Tyr Arg Arg Tyr Arg Phe 
        35                  40                  45              


Thr Gly Phe Tyr 
    50          


<210> 5590
<211> 84
<212> PRT
<213> Homo sapiens

<400> 5590
Met Ser Tyr Tyr Gly Ser Tyr Tyr Arg Gly Leu Gly Tyr Gly Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          


Arg Arg Leu Gly Tyr Gly Cys Gly Phe Gly Gly Asn Gly Tyr Gly Tyr 
        35                  40                  45              


Cys Arg Pro Ser Cys Tyr Gly Gly Tyr Gly Phe Ser Ile Leu Leu Lys 
    50                  55                  60                  


Ser Tyr Pro Glu Asp Thr Ile Ser Glu Val Ile Arg Arg Ser Phe Asn 
65                  70                  75                  80  


Leu Thr Lys Tyr 
                


<210> 5591
<211> 81
<212> PRT
<213> Homo sapiens

<400> 5591
Met Ser Tyr Tyr Gly Ser Tyr Tyr Gly Gly Leu Gly Tyr Gly Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          


Arg Arg Leu Gly Ser Gly Cys Gly Tyr Gly Gly Tyr Gly Tyr Gly Ser 
        35                  40                  45              


Gly Phe Gly Gly Tyr Gly Tyr Gly Ser Gly Phe Gly Gly Tyr Gly Tyr 
    50                  55                  60                  


Gly Cys Tyr Arg Pro Ser Tyr Tyr Gly Gly Tyr Gly Phe Ser Gly Phe 
65                  70                  75                  80  


Tyr 
    


<210> 5592
<211> 137
<212> PRT
<213> Homo sapiens

<400> 5592
Met Ser Tyr Asn Cys Ser Ser Gly Asn Phe Ser Ser Cys Cys Phe Gly 
1               5                   10                  15      


Ser Tyr Leu Arg Tyr Pro Val Ser Thr Tyr Asn Leu Phe Tyr Pro Ser 
            20                  25                  30          


Asn Ala Ile Tyr Ser Pro Asn Thr Cys Gln Leu Gly Ser Ser Leu Tyr 
        35                  40                  45              


Asn Gly Cys Gln Glu Thr Tyr Cys Glu Pro Thr Ser Cys Gln Thr Ser 
    50                  55                  60                  


Cys Thr Leu Ala Arg Ser Tyr Gln Thr Ser Cys Tyr Cys Pro Lys Asn 
65                  70                  75                  80  


Ser Ile Phe Cys Ser Pro Arg Gln Thr Asn Tyr Ile Arg Ser Leu Gly 
                85                  90                  95      


Cys Gly Asn Thr Gly Leu Gly Ser Leu Gly Cys Gly Ser Thr Gly Phe 
            100                 105                 110         


Gln Ser Leu Asp Cys Gly Ser Ser Phe Tyr His Pro Thr Thr Phe Ser 
        115                 120                 125             


Ser Arg Asn Phe Gln Ala Thr Cys Tyr 
    130                 135         


<210> 5593
<211> 160
<212> PRT
<213> Homo sapiens

<400> 5593
Met Ser Tyr Asn Cys Cys Ser Arg Asn Phe Ser Ser Arg Ser Phe Gly 
1               5                   10                  15      


Gly Tyr Leu Tyr Tyr Pro Gly Ser Tyr Pro Ser Ser Leu Val Tyr Ser 
            20                  25                  30          


Thr Ala Leu Cys Ser Pro Ser Thr Cys Gln Leu Arg Ser Ser Leu Tyr 
        35                  40                  45              


Arg Asp Cys Gln Lys Thr Cys Trp Glu Pro Ala Ser Cys Gln Lys Ser 
    50                  55                  60                  


Cys Tyr Arg Pro Arg Thr Ser Ile Leu Cys Cys Pro Cys Gln Thr Thr 
65                  70                  75                  80  


Cys Ser Gly Ser Leu Gly Phe Arg Ser Ser Ser Cys Arg Ser Gln Gly 
                85                  90                  95      


Tyr Gly Ser Arg Cys Cys Tyr Ser Leu Gly Asn Gly Ser Ser Gly Phe 
            100                 105                 110         


Arg Phe Leu Lys Tyr Gly Gly Cys Gly Phe Pro Ser Leu Ser Tyr Gly 
        115                 120                 125             


Ser Arg Phe Cys Tyr Pro Asn Tyr Leu Ala Ser Gly Ala Trp Gln Ser 
    130                 135                 140                 


Ser Cys Tyr Arg Pro Ile Cys Gly Ser Arg Phe Tyr Gln Phe Thr Cys 
145                 150                 155                 160 


<210> 5594
<211> 227
<212> PRT
<213> Homo sapiens

<400> 5594
Met Leu Asn Pro Asp Gly Val Tyr Leu Gly Asn Tyr Arg Cys Ser Leu 
1               5                   10                  15      


Met Gly Phe Asp Leu Asn Arg His Trp Leu Asp Pro Ser Pro Trp Val 
            20                  25                  30          


His Pro Thr Leu His Gly Val Lys Gln Leu Ile Val Gln Met Tyr Asn 
        35                  40                  45              


Asp Pro Lys Thr Ser Leu Glu Phe Tyr Ile Asp Ile His Ala His Ser 
    50                  55                  60                  


Thr Met Met Asn Gly Phe Met Tyr Gly Asn Ile Phe Glu Asp Glu Glu 
65                  70                  75                  80  


Arg Phe Gln Arg Gln Ala Ile Phe Pro Lys Leu Leu Cys Gln Asn Ala 
                85                  90                  95      


Glu Asp Phe Ser Tyr Ser Ser Thr Ser Phe Asn Arg Asp Ala Val Lys 
            100                 105                 110         


Ala Gly Thr Gly Arg Arg Phe Leu Gly Gly Leu Leu Asp His Thr Ser 
        115                 120                 125             


Tyr Cys Tyr Thr Leu Glu Val Ser Phe Tyr Ser Tyr Ile Ile Ser Gly 
    130                 135                 140                 


Thr Thr Ala Ala Val Pro Tyr Thr Glu Glu Ala Tyr Met Lys Leu Gly 
145                 150                 155                 160 


Arg Asn Val Ala Arg Thr Phe Leu Asp Tyr Tyr Arg Leu Asn Pro Val 
                165                 170                 175     


Val Glu Lys Val Ala Ile Pro Met Pro Arg Leu Arg Lys Glu Lys Ser 
            180                 185                 190         


Pro Pro Tyr Lys His Pro Leu Leu Arg Gly Pro Ala Ser Asn Tyr Pro 
        195                 200                 205             


Asn Ser Lys Gly Asp Lys Lys Ser Ser Val Asn His Lys Asp Pro Ser 
    210                 215                 220                 


Thr Pro Phe 
225         


<210> 5595
<211> 154
<212> PRT
<213> Homo sapiens

<400> 5595
Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys Arg Thr 
1               5                   10                  15      


Thr Cys Cys Arg Thr Thr Cys Trp Lys Pro Thr Thr Val Thr Thr Cys 
            20                  25                  30          


Ser Ser Thr Pro Cys Cys Gln Pro Ser Cys Cys Val Ser Ser Cys Cys 
        35                  40                  45              


Gln Pro Cys Cys Arg Pro Thr Cys Cys Gln Asn Thr Cys Cys Gln Pro 
    50                  55                  60                  


Thr Cys Val Thr Ser Cys Cys Gln Pro Ser Cys Cys Ser Thr Pro Cys 
65                  70                  75                  80  


Cys Gln Pro Thr Cys Cys Gly Ser Ser Cys Asp Gln Ser Ser Ser Cys 
                85                  90                  95      


Ala Pro Val Tyr Cys Arg Arg Thr Cys Tyr Tyr Pro Thr Thr Val Cys 
            100                 105                 110         


Leu Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Asn Cys Cys Gln Pro 
        115                 120                 125             


Cys Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Phe Gln Pro Thr Cys 
    130                 135                 140                 


Val Ser Ser Cys Cys Gln Pro Phe Cys Cys 
145                 150                 


<210> 5596
<211> 2353
<212> PRT
<213> Homo sapiens

<400> 5596
Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Thr Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Thr Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Thr Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Thr Ser Asp Gly Thr Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Thr Glu Pro Lys Ala Val Arg Thr Thr Thr Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Thr Ser Tyr Leu Thr Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Thr Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Thr His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Thr Ile Val Ser Ser Thr Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Thr Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Thr Thr Asp Met Thr Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Thr Glu Pro Ser Ser Thr Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Thr Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Thr Thr Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Thr Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Thr Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Thr Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Thr Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Thr Ser Met Leu Leu Asp Gln Val His Pro Pro 
            340                 345                 350         


Ile Asn Glu Asp Ser Leu Arg Ala Ser Thr Gln Ile Arg Ala Phe Ser 
        355                 360                 365             


Arg Asn Arg Phe Lys Asp His Ile Glu Asp His Leu Leu Pro Ser Thr 
    370                 375                 380                 


Glu Asn Thr Phe Trp Arg His Asp Thr Lys Ala Asp Thr Arg Ala Ile 
385                 390                 395                 400 


Gln Leu Leu Leu Gly Ser Ala Glu Leu Ser Gln Gly Asn Phe Trp Asp 
                405                 410                 415     


Gly Leu Gly Ser Pro Pro Asp Ser Pro Ser Pro Gly Ser Asp Val Tyr 
            420                 425                 430         


Cys Ile Ser Glu Leu Asn Asp Pro Gln Tyr Asp Gln Ser Leu Leu Glu 
        435                 440                 445             


Asn Leu Phe Tyr Thr Ala Pro Lys Ser Asp Thr Ser Ile Ser Asp Phe 
    450                 455                 460                 


Leu Ser Glu Glu Asp Asp Ile Val Pro Ser Lys Lys Ile Ser Gln Ser 
465                 470                 475                 480 


Thr Ala Leu Ala Arg Ser Ser Lys Val Leu Glu Ser Ser Asp His Lys 
                485                 490                 495     


Leu Lys Lys Arg Ser Ala Gly Lys Arg Asn Arg Asn Leu Val Glu Gln 
            500                 505                 510         


Gln Met Leu Ser Glu Thr Pro Glu Asp Ala Gln Thr Met Thr Leu Ser 
        515                 520                 525             


Val Asp Arg Leu Ala Leu Leu Gly Arg Thr His Ser Val Arg Ile Ile 
    530                 535                 540                 


Ile Glu Thr Met Gly Val Pro Pro Asp Ser Pro Gln Met Thr Pro Gly 
545                 550                 555                 560 


Lys Lys Ser Tyr Ala Gly Pro Pro Pro Lys Val Thr Thr Ala Lys Lys 
                565                 570                 575     


Arg Thr Phe Phe Val Glu Tyr His Phe Pro Val Gly Phe Ser Glu Ser 
            580                 585                 590         


Gly Leu Gly Lys Thr Ala Leu Ile Thr Glu Val Val Arg Leu Ala Ser 
        595                 600                 605             


Ser Lys Ile Thr Asp Gly Lys Val Lys Phe Gln Gln Arg Phe Val Phe 
    610                 615                 620                 


Pro Val Gln Phe Gly Gly Pro Met Ile Glu His Trp Trp Asn Ser Asn 
625                 630                 635                 640 


Leu Thr Phe Gln Ile Tyr Val Lys Lys Thr Pro Gln Lys Lys Pro Glu 
                645                 650                 655     


Val Ile Gly Ser Val Ser Leu Ser Leu Arg Ala Val Ile Gln Ser Glu 
            660                 665                 670         


Leu Leu Ser Phe Ser Asp Gln Leu Pro Val Gln Gln Glu Asn Gly Gln 
        675                 680                 685             


Ser Pro Phe Gly Pro Leu Lys Val Thr Met Glu Leu Ile Thr Asp Asn 
    690                 695                 700                 


Lys Asp Phe Thr Gly Ile Asn Thr Lys Leu Ser Gly Asn Thr His Tyr 
705                 710                 715                 720 


Thr Pro Leu Cys Ala Pro Thr Ser Pro Asn Lys Ala Leu Pro Glu Leu 
                725                 730                 735     


Asn Gln Asp Met Thr Cys Thr Lys Asn Pro Gln Asn Leu Asn Gln Ile 
            740                 745                 750         


His Glu Glu Thr Ala Lys Lys Ala Gln Asn Leu Val Leu Pro Asn Arg 
        755                 760                 765             


Lys Ser Pro Ser Pro Val Ala Pro His Pro Ser Thr Phe Val Ala Thr 
    770                 775                 780                 


Pro Ala Ser His Asn Leu Val Asn Gln Thr Asn Gly Thr Thr Lys Glu 
785                 790                 795                 800 


Ser Ala Leu Leu Leu His Val Leu Leu Met Val Pro Asp Gly Lys Asp 
                805                 810                 815     


Phe Ile Ser Gly Glu Ser Glu Lys Gln Ser Pro Cys Asn Val Tyr Leu 
            820                 825                 830         


Asn Cys Lys Leu Phe Ser Thr Glu Glu Val Thr Arg Ser Val Ile Ala 
        835                 840                 845             


Trp Gly Thr Thr Gln Pro Val Phe Asn Phe Ser Gln Val Ile Pro Val 
    850                 855                 860                 


Ser Leu Ser Ser Lys Tyr Leu Glu Arg Leu Lys Asn Asn Val Met Val 
865                 870                 875                 880 


Ile Glu Thr Trp Asn Lys Val Arg Ser Pro Gly Gln Asp Lys Leu Leu 
                885                 890                 895     


Gly Leu Val Lys Leu Pro Leu His Gln Phe Tyr Met Ser Phe Lys Asp 
            900                 905                 910         


Ala Lys Ile Ser Arg Leu Leu Leu Asp Ala Gln Tyr Pro Val Val Ala 
        915                 920                 925             


Val Asp Ser Tyr Met Pro Val Ile Asp Val Phe Ser Gly His Gln Asn 
    930                 935                 940                 


Gly Ser Leu Arg Val Phe Leu Ala Met Gly Ser Ser Asn Gln Ile Met 
945                 950                 955                 960 


Ala Leu Gln Arg Leu Lys Asn Glu Glu Gly Thr Leu Pro Pro Phe Ser 
                965                 970                 975     


Pro Arg Pro Ala His Phe Leu Asp Gln Pro Thr Ala Ala Ser Val Ala 
            980                 985                 990         


Met Ala Glu Asp Arg Gly Asn Gly  Leu Met Glu His Cys  Phe Glu Ile 
        995                 1000                 1005             


His Ile  Glu Met Val Lys Gly  Leu Ala Pro Leu Gln  Ala Thr Val 
    1010                 1015                 1020             


Trp Gly  Glu Ala Asp Cys Tyr  Val Gln Tyr Tyr Phe  Pro Val Gln 
    1025                 1030                 1035             


His Ser  Gln Ser Ser Val Leu  Lys Gly Pro Glu Phe  Leu Glu Asn 
    1040                 1045                 1050             


Gly Ile  Thr Leu Lys Pro Phe  Arg Thr Ala Thr Thr  Leu Cys Val 
    1055                 1060                 1065             


Pro Asp  Pro Ile Phe Asn Ser  Glu His His His Ser  Leu Leu Leu 
    1070                 1075                 1080             


Pro Ala  Glu Val Pro Val Gln  Arg Leu Leu Leu Ser  Ala Phe Ser 
    1085                 1090                 1095             


Ala Gln  Gly Leu Val Pro Gly  Gly Gly Val Gln Phe  Glu Ile Trp 
    1100                 1105                 1110             


Cys Arg  Tyr Tyr Tyr Pro Asn  Val Arg Asp Gln Lys  Val Ala Lys 
    1115                 1120                 1125             


Gly Thr  Leu Pro Leu Ser Arg  Ile Cys Ala Met Val  Thr Thr Gln 
    1130                 1135                 1140             


His Arg  Glu Asp Val Gly Ile  Gln Thr Phe Asn Leu  Pro Leu Thr 
    1145                 1150                 1155             


Pro Arg  Ile Glu Asn Arg Lys  Glu Leu Arg Asn Gln  Ser Ser Gly 
    1160                 1165                 1170             


Leu Leu  Asp Val Gly Leu Arg  Tyr Arg Arg Ser Pro  Arg Thr Ala 
    1175                 1180                 1185             


Glu Gly  Val Leu Ala Ala Arg  Thr Val Ser Ile Ser  Val Gln Ile 
    1190                 1195                 1200             


Ile Arg  Ala Cys Gly Leu Gln  Ala Ala Ala Lys Ala  Leu Ala Glu 
    1205                 1210                 1215             


Arg Glu  Pro Ala Leu Gln Phe  Ser Ala Thr Val Gly  Val Asn Ala 
    1220                 1225                 1230             


Ser Val  Thr Thr His Leu Ser  Phe Leu Pro Gln Gly  Glu Gln Arg 
    1235                 1240                 1245             


Arg Thr  His Pro Val Ala Cys  Ser Phe Cys Pro Glu  Phe Ser His 
    1250                 1255                 1260             


His Val  Glu Phe Thr Cys Asn  Leu Val Thr Gln His  Cys Ser Gly 
    1265                 1270                 1275             


Glu Ala  Cys Phe Leu Ala Glu  Leu Leu Glu Phe Ala  Glu Val Ile 
    1280                 1285                 1290             


Phe Ala  Val Tyr His Glu Asn  Thr Lys Ser Ala Ser  Asp Ile Ile 
    1295                 1300                 1305             


Ser Ile  Glu Ser Cys Lys Glu  Tyr Leu Leu Gly Val  Val Lys Val 
    1310                 1315                 1320             


Pro Thr  Lys Glu Leu Leu Ile  Lys Arg Ser Gly Ile  Thr Gly Trp 
    1325                 1330                 1335             


Tyr Pro  Ile Ile Leu Pro Glu  Asp Gly Gly Leu Pro  His Gly Leu 
    1340                 1345                 1350             


Glu Leu  Met Gln Lys Ile Val  Gly Gly Leu Glu Leu  Ser Ile Ser 
    1355                 1360                 1365             


Phe Thr  His Arg Gly Asp Arg  Glu Arg Val Leu Glu  Ala Ala Glu 
    1370                 1375                 1380             


His Leu  Gly Trp Ser Phe Glu  Asn Ser Leu Lys Asp  Phe Val Arg 
    1385                 1390                 1395             


Met Asp  Glu Gly Glu Pro Ala  Thr Val Thr Ile Ser  Thr Pro Arg 
    1400                 1405                 1410             


Leu Trp  Leu Pro Ile His Cys  Val Leu Leu Ala Gly  His Asn His 
    1415                 1420                 1425             


Ile His  Lys Asn Thr Tyr Cys  Tyr Leu Arg Tyr Lys  Phe Tyr Asp 
    1430                 1435                 1440             


His Glu  Ala Phe Trp Thr Pro  Leu Lys Lys Pro Lys  Glu Ser Val 
    1445                 1450                 1455             


Asn Lys  Lys Gln Ile Met Val  Thr Phe Lys Ala Ser  Lys Arg Ala 
    1460                 1465                 1470             


Glu Val  Thr Arg Gly Pro Ser  Leu Leu Trp Tyr Phe  Arg Glu Glu 
    1475                 1480                 1485             


Arg Leu  Glu Ile Gln Val Trp  Arg Ala Tyr Gly Asn  Asp Ser Val 
    1490                 1495                 1500             


Glu Arg  Pro His Gln Thr Asp  Ser Trp Ile Gly Ser  Ala Tyr Val 
    1505                 1510                 1515             


Asp Leu  Ala Arg Leu Gly Glu  Arg Ser Ala Arg Thr  Leu Thr Val 
    1520                 1525                 1530             


Ser Gly  Val Tyr Pro Leu Phe  Gly Arg Asn Ala Ser  Asn Leu Ser 
    1535                 1540                 1545             


Gly Ala  Ala Leu Arg Val His  Val Val Leu Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


His Leu  Glu Pro Thr His Glu  Leu Asp Ser Met Asp  Cys Ser Ser 
    1565                 1570                 1575             


His Ser  Glu Ser Glu Gln Leu  Pro Arg Arg Asn Asp  Glu Val Gln 
    1580                 1585                 1590             


Leu Ser  Pro Pro Glu Val Ile  Ser Cys His Gln Lys  Ser Pro Ala 
    1595                 1600                 1605             


Ser Thr  Gln Val Pro Cys Ser  Ser Thr Thr Ala Glu  Val Arg Leu 
    1610                 1615                 1620             


Thr Gln  Glu Gly Pro Ala Asp  Leu Asp Gly Thr Phe  Ala Val Ser 
    1625                 1630                 1635             


Ile Leu  Val Glu Arg Ala Met  His Leu Ser Leu Lys  Gly Ser Pro 
    1640                 1645                 1650             


Leu Thr  Glu Arg Lys Val Ser  Ile Pro Ser Cys Cys  Val Ser Phe 
    1655                 1660                 1665             


Ala Thr  Ala Asp Glu Ser Ser  Pro Val Tyr Thr Gln  Val Val Glu 
    1670                 1675                 1680             


Asn Thr  Asp Ser Pro Ile Trp  Asn Phe Gln Gln Gln  Ser Arg Leu 
    1685                 1690                 1695             


Ser Lys  Glu Leu Leu Leu Asp  Pro Gln Gln Thr Leu  Val Phe Lys 
    1700                 1705                 1710             


Val Trp  His Lys Gly Asp Glu  Glu Arg Val Ile Gly  Phe Ala Ser 
    1715                 1720                 1725             


Val Asp  Leu Ser Pro Leu Leu  Ser Gly Phe Gln Phe  Val Cys Gly 
    1730                 1735                 1740             


Trp Tyr  Asn Ile Thr Asp Phe  Ser Gly Glu Cys Gln  Gly Gln Ile 
    1745                 1750                 1755             


Lys Val  Ala Val Ser Pro Leu  Glu Ser Leu Ile His  Phe Lys Glu 
    1760                 1765                 1770             


Glu Arg  Gln Ala Arg Arg Gly  Val Glu Thr Ser Lys  Ser Leu Ile 
    1775                 1780                 1785             


Pro Ile  Tyr Ser Pro Phe Ser  Phe Pro Ala Ser Asp  Thr Tyr Ala 
    1790                 1795                 1800             


Ala Phe  Ser Ser His Met Ala  Arg Gln Thr Leu Asp  Gln Leu Ala 
    1805                 1810                 1815             


His Ala  Ser Ser Lys Glu Leu  Asp Phe Ser Ser Pro  Gly Arg Ser 
    1820                 1825                 1830             


Asp Thr  Thr Arg Ser Gln Ala  Ser Arg His Glu Glu  His Val Gln 
    1835                 1840                 1845             


Asn Ile  Arg Arg Phe His Glu  Ser Leu His Leu Gln  Gly Glu Ala 
    1850                 1855                 1860             


Pro Leu  Pro Cys Asp Asp Lys  Leu Thr Thr Ser Pro  Leu Ser Ser 
    1865                 1870                 1875             


Gln Thr  Ser Ile Leu Thr Ser  Leu Arg Lys Asn Leu  Ser Glu Leu 
    1880                 1885                 1890             


Asp Gln  Ile Gln Arg Tyr Phe  Arg Gln Lys Leu Thr  Lys Pro Phe 
    1895                 1900                 1905             


Leu Pro  Leu Ser Pro Gln Thr  Gln Thr Ala Ile Ser  Gln His Gln 
    1910                 1915                 1920             


Glu Ser  Cys Arg Asp His Leu  Gly Pro Gly Ala Ser  Ser Leu Asp 
    1925                 1930                 1935             


Pro Gly  Ser Gln Cys Ile Leu  Glu Lys Ser Ser Asn  Leu Val Leu 
    1940                 1945                 1950             


Gln Val  Ser Ser Leu Ile Thr  Asp Leu Gln Thr Ile  Thr Arg Asp 
    1955                 1960                 1965             


Ser Gln  Ala Ala Leu Ser Ser  His Arg Ala Arg Ser  Arg Ser Asn 
    1970                 1975                 1980             


Lys Ala  Thr Thr Leu Pro Asp  Ala Gln Asp Thr Glu  Ala Leu Gln 
    1985                 1990                 1995             


Glu Arg  Cys Thr Met Pro Asp  Glu Pro Leu Val Arg  Ala Pro Asp 
    2000                 2005                 2010             


Lys Gly  Thr Asp Ser Pro Ser  Pro Pro Pro Leu Glu  Glu Thr Ser 
    2015                 2020                 2025             


Asn Gly  Gly Arg Met Leu His  Glu Ser Leu Arg His  Ala Val Pro 
    2030                 2035                 2040             


Ile Thr  Arg Met Gln Ser Ser  Glu Asp Thr Glu Ala  Gly Pro Ala 
    2045                 2050                 2055             


Tyr Ser  Asp Glu Asp Tyr Glu  Glu Asp Ile Ile Glu  Pro Arg Thr 
    2060                 2065                 2070             


Leu Asn  Glu Ile Thr Thr Val  Thr Asp Lys Thr Ser  Pro Trp Ser 
    2075                 2080                 2085             


Ser Val  Ile Ser Asp Thr Ser  Glu Val Ile Ser Pro  Gln Pro Asp 
    2090                 2095                 2100             


Glu Val  Gln Arg Glu Gly Pro  Ser Cys Pro Ser Pro  Gly Pro Phe 
    2105                 2110                 2115             


Cys Arg  Glu Glu Leu Met Val  Lys Ser Ser Phe Leu  Ser Ser Pro 
    2120                 2125                 2130             


Glu Arg  Ala Val Asn Pro His  Leu Pro Arg Gln Gly  Ser Pro Ser 
    2135                 2140                 2145             


Gln Ser  Leu Val Ala Cys Glu  Cys Glu Ala Ser Lys  Ala Arg Val 
    2150                 2155                 2160             


Gly Gly  Glu Ser Ala Ser Ala  Asn Pro Gln Pro Ile  Pro Cys Pro 
    2165                 2170                 2175             


Thr Leu  Ser Gly Ala Gln Gln  Ser Ser Thr Phe Val  Gly Trp Ser 
    2180                 2185                 2190             


Ser Pro  Gln Thr Asp Gln Asn  Lys Glu Pro Lys Ser  Glu Ala Pro 
    2195                 2200                 2205             


Ala Glu  Asn Glu Ala Ala Thr  Ser Glu Leu Gly Asp  Ser Ala Asp 
    2210                 2215                 2220             


Ser Phe  Lys Lys Leu Pro Leu  Asn Leu Ala Ser Gln  Ser Arg Arg 
    2225                 2230                 2235             


Glu Asn  His Lys Gly Pro Pro  Ile Asp Ser Ser Asp  Ile Arg Gln 
    2240                 2245                 2250             


Arg Gln  Val Thr Thr Gly Ser  Glu Thr Ser Thr Lys  Gln Ser Leu 
    2255                 2260                 2265             


Leu Leu  Pro Gly Pro Ile Val  Val Pro Asn Phe Phe  Leu Pro Pro 
    2270                 2275                 2280             


Gln Gln  Leu Glu Ala Ser Leu  Arg Met Leu Ser Leu  Ser Ala Thr 
    2285                 2290                 2295             


Leu Pro  Pro Ala Ala Thr Thr  Asp Gln Asp Lys Ser  Glu Ala Thr 
    2300                 2305                 2310             


Arg Gly  Ala Leu Ser Gln Arg  Pro Cys Arg Pro Arg  Pro Asn Ser 
    2315                 2320                 2325             


Leu Pro  Leu Asn Leu Pro Glu  Glu Glu Thr Leu Arg  Ile Ala Arg 
    2330                 2335                 2340             


Ile Phe  Ser Ser Gln Tyr Ser  Gln Lys Asp 
    2345                 2350             


<210> 5597
<211> 72
<212> PRT
<213> Homo sapiens

<400> 5597
Met Asn Tyr Tyr Gly Asn Tyr Tyr Gly Gly Leu Gly Tyr Gly Tyr Gly 
1               5                   10                  15      


Gly Phe Asp Asp Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          


Arg Arg Leu Gly Tyr Gly Gly Gly Tyr Gly Gly Tyr Gly Tyr Gly Ser 
        35                  40                  45              


Gly Phe Gly Gly Tyr Gly Tyr Arg Ser Cys Arg Pro Ser Cys Tyr Gly 
    50                  55                  60                  


Gly Tyr Gly Phe Ser Gly Phe Tyr 
65                  70          


<210> 5598
<211> 65
<212> PRT
<213> Homo sapiens

<400> 5598
Met Ser Tyr Asn Cys Cys Cys Gly Asn Phe Ser Ser His Ser Cys Glu 
1               5                   10                  15      


Gly Tyr Leu Cys Tyr Ser Gly Tyr Ser Arg Gly Gly Ser Ser Tyr Pro 
            20                  25                  30          


Ser Asn Leu Val Tyr Ser Thr Glu Pro Leu Ile Ser Gln His Leu Pro 
        35                  40                  45              


Ala Gly Phe Leu Ser Leu Gln Gly Leu Ser Gly Asp Leu Leu Gly Asn 
    50                  55                  60                  


Pro 
65  


<210> 5599
<211> 127
<212> PRT
<213> Homo sapiens

<400> 5599
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Asp 
1               5                   10                  15      


Gln Gly Leu Cys Gln Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr 
            20                  25                  30          


Thr Cys Cys Cys Pro Ser Cys Val Val Ser Ser Cys Cys Arg Pro Ser 
        35                  40                  45              


Cys Ser Gln Thr Thr Cys Cys Gln Thr Thr Cys Cys Arg Pro Ser Cys 
    50                  55                  60                  


Cys His Pro Val Cys Cys Gln Thr Thr Cys Arg Pro Ser Cys Gly Val 
65                  70                  75                  80  


Ser Ser Cys Cys Arg Pro Leu Cys Cys Gln Thr Thr Cys Arg Pro Ser 
                85                  90                  95      


Cys Gly Val Ser Ser Cys Cys Arg Pro Leu Cys Cys Gln Thr Thr Cys 
            100                 105                 110         


Cys Arg Ala Thr Cys Cys Arg Pro Ser Cys Cys Gly Ser Ser Cys 
        115                 120                 125         


<210> 5600
<211> 105
<212> PRT
<213> Homo sapiens

<400> 5600
Met Gly Cys Cys Pro Gly Asp Cys Phe Thr Cys Cys Thr Gln Glu Gln 
1               5                   10                  15      


Asn Cys Cys Glu Glu Cys Cys Cys Gln Pro Gly Cys Cys Gly Cys Cys 
            20                  25                  30          


Gly Ser Cys Cys Gly Cys Gly Gly Ser Gly Cys Gly Gly Ser Gly Cys 
        35                  40                  45              


Gly Gly Ser Cys Cys Gly Ser Ser Cys Cys Gly Ser Gly Cys Gly Gly 
    50                  55                  60                  


Cys Gly Gly Cys Gly Gly Cys Gly Gly Gly Cys Cys Gly Ser Ser Cys 
65                  70                  75                  80  


Cys Gly Ser Ser Cys Cys Gly Ser Gly Cys Cys Gly Pro Val Cys Cys 
                85                  90                  95      


Gln Pro Thr Pro Ile Cys Asp Thr Lys 
            100                 105 


<210> 5601
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 5601
Met Glu Glu Ile Pro Val Lys Val Ala Val Arg Ile Arg Pro Leu Leu 
1               5                   10                  15      


Cys Lys Glu Ala Leu His Asn His Gln Val Cys Val Arg Val Ile Pro 
            20                  25                  30          


Asn Ser Gln Gln Val Ile Ile Gly Arg Asp Arg Val Phe Thr Phe Asp 
        35                  40                  45              


Phe Val Phe Gly Lys Asn Ser Thr Gln Asp Glu Val Tyr Asn Thr Cys 
    50                  55                  60                  


Ile Lys Pro Leu Val Leu Ser Leu Ile Glu Gly Tyr Asn Ala Thr Val 
65                  70                  75                  80  


Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr Tyr Thr Ile Gly Gly 
                85                  90                  95      


Gly His Ile Ala Ser Val Val Glu Gly Gln Lys Gly Ile Ile Pro Arg 
            100                 105                 110         


Ala Ile Gln Glu Ile Phe Gln Ser Ile Ser Glu His Pro Ser Ile Asp 
        115                 120                 125             


Phe Asn Val Lys Val Ser Tyr Ile Glu Val Tyr Lys Glu Asp Leu Arg 
    130                 135                 140                 


Asp Leu Leu Glu Leu Glu Thr Ser Met Lys Asp Leu His Ile Arg Glu 
145                 150                 155                 160 


Asp Glu Lys Gly Asn Thr Val Ile Val Gly Ala Lys Glu Cys His Val 
                165                 170                 175     


Glu Ser Ala Gly Glu Val Met Ser Leu Leu Glu Met Gly Asn Ala Ala 
            180                 185                 190         


Arg His Thr Gly Thr Thr Gln Met Asn Glu His Ser Ser Arg Ser His 
        195                 200                 205             


Ala Ile Phe Thr Ile Ser Ile Cys Gln Val His Lys Asn Met Glu Ala 
    210                 215                 220                 


Ala Glu Asp Gly Ser Trp Tyr Ser Pro Arg His Ile Val Ser Lys Phe 
225                 230                 235                 240 


His Phe Val Asp Leu Ala Gly Ser Glu Arg Val Thr Lys Thr Gly Asn 
                245                 250                 255     


Thr Gly Glu Arg Phe Lys Glu Ser Ile Gln Ile Asn Ser Gly Leu Leu 
            260                 265                 270         


Ala Leu Gly Asn Val Ile Ser Ala Leu Gly Asp Pro Arg Arg Lys Ser 
        275                 280                 285             


Ser His Ile Pro Tyr Arg Asp Ala Lys Ile Thr Arg Leu Leu Lys Asp 
    290                 295                 300                 


Ser Leu Gly Gly Ser Ala Lys Thr Val Met Ile Thr Cys Val Ser Pro 
305                 310                 315                 320 


Ser Ser Ser Asn Phe Asp Glu Ser Leu Asn Ser Leu Lys Tyr Ala Asn 
                325                 330                 335     


Arg Ala Arg Asn Ile Arg Asn Lys Pro Thr Val Asn Phe Ser Pro Glu 
            340                 345                 350         


Ser Asp Arg Ile Asp Glu Met Glu Phe Glu Ile Lys Leu Leu Arg Glu 
        355                 360                 365             


Ala Leu Gln Ser Gln Gln Ala Gly Val Ser Gln Thr Thr Gln Ile Asn 
    370                 375                 380                 


Arg Glu Gly Ser Pro Asp Thr Asn Arg Ile His Ser Leu Glu Glu Gln 
385                 390                 395                 400 


Val Ala Gln Leu Gln Gly Glu Cys Leu Gly Tyr Gln Cys Cys Val Glu 
                405                 410                 415     


Glu Ala Phe Thr Phe Leu Val Asp Leu Lys Asp Thr Val Arg Leu Asn 
            420                 425                 430         


Glu Lys Gln Gln His Lys Leu Gln Glu Trp Phe Asn Met Ile Gln Glu 
        435                 440                 445             


Val Arg Lys Ala Val Leu Thr Ser Phe Arg Gly Ile Gly Gly Thr Ala 
    450                 455                 460                 


Ser Leu Glu Glu Gly Pro Gln His Val Thr Val Leu Gln Leu Lys Arg 
465                 470                 475                 480 


Glu Leu Lys Lys Cys Gln Cys Val Leu Ala Ala Asp Glu Val Val Phe 
                485                 490                 495     


Asn Gln Lys Glu Leu Glu Val Lys Glu Leu Lys Asn Gln Val Gln Met 
            500                 505                 510         


Met Val Gln Glu Asn Lys Gly His Ala Val Ser Leu Lys Glu Ala Gln 
        515                 520                 525             


Lys Val Asn Arg Leu Gln Asn Glu Lys Ile Ile Glu Gln Gln Leu Leu 
    530                 535                 540                 


Val Asp Gln Leu Ser Glu Glu Leu Thr Lys Leu Asn Leu Ser Val Thr 
545                 550                 555                 560 


Ser Ser Ala Lys Glu Asn Cys Gly Asp Gly Pro Asp Ala Arg Ile Pro 
                565                 570                 575     


Glu Arg Arg Pro Tyr Thr Val Pro Phe Asp Thr His Leu Gly His Tyr 
            580                 585                 590         


Ile Tyr Ile Pro Ser Arg Gln Asp Ser Arg Lys Val His Thr Ser Pro 
        595                 600                 605             


Pro Met Tyr Ser Leu Asp Arg Ile Phe Ala Gly Phe Arg Thr Arg Ser 
    610                 615                 620                 


Gln Met Leu Leu Gly His Ile Glu Glu Gln Asp Lys Val Leu His Cys 
625                 630                 635                 640 


Gln Phe Ser Asp Asn Ser Asp Asp Glu Glu Ser Glu Gly Gln Glu Lys 
                645                 650                 655     


Ser Gly Thr Arg Cys Arg Ser Arg Ser Trp Ile Gln Lys Pro Asp Ser 
            660                 665                 670         


Val Cys Ser Leu Val Glu Leu Ser Asp Thr Gln Asp Glu Thr Gln Lys 
        675                 680                 685             


Ser Asp Leu Glu Asn Glu Asp Leu Lys Ile Asp Cys Leu Gln Glu Ser 
    690                 695                 700                 


Gln Glu Leu Asn Leu Gln Lys Leu Lys Asn Ser Glu Arg Ile Leu Thr 
705                 710                 715                 720 


Glu Ala Lys Gln Lys Met Arg Glu Leu Thr Ile Asn Ile Lys Met Lys 
                725                 730                 735     


Glu Asp Leu Ile Lys Glu Leu Ile Lys Thr Gly Asn Asp Ala Lys Ser 
            740                 745                 750         


Val Ser Lys Gln Tyr Ser Leu Lys Val Thr Lys Leu Glu His Asp Ala 
        755                 760                 765             


Glu Gln Ala Lys Val Glu Leu Ile Glu Thr Gln Lys Gln Leu Gln Glu 
    770                 775                 780                 


Leu Glu Asn Lys Asp Leu Ser Asp Val Ala Met Lys Val Lys Leu Gln 
785                 790                 795                 800 


Lys Glu Phe Arg Lys Lys Met Asp Ala Ala Lys Leu Arg Val Gln Val 
                805                 810                 815     


Leu Gln Lys Lys Gln Gln Asp Ser Lys Lys Leu Ala Ser Leu Ser Ile 
            820                 825                 830         


Gln Asn Glu Lys Arg Ala Asn Glu Leu Glu Gln Ser Val Asp His Met 
        835                 840                 845             


Lys Tyr Gln Lys Ile Gln Leu Gln Arg Lys Leu Arg Glu Glu Asn Glu 
    850                 855                 860                 


Lys Arg Lys Gln Leu Asp Ala Val Ile Lys Arg Asp Gln Gln Lys Ile 
865                 870                 875                 880 


Lys Ala Leu Asn Thr Asp Ser Leu Lys Ile Ser Thr Arg Leu Asn Leu 
                885                 890                 895     


Leu Glu Gln Glu Leu Ser Glu Lys Asn Val Gln Leu Gln Thr Ser Thr 
            900                 905                 910         


Ala Glu Glu Lys Thr Lys Ile Ser Glu Gln Val Glu Val Leu Gln Lys 
        915                 920                 925             


Glu Lys Asp Gln Leu Gln Lys Arg Arg His Asn Val Asp Glu Lys Leu 
    930                 935                 940                 


Lys Asn Gly Arg Val Leu Ser Pro Glu Glu Glu His Val Leu Phe Gln 
945                 950                 955                 960 


Leu Glu Glu Gly Ile Glu Ala Leu Glu Ala Ala Ile Glu Tyr Arg Asn 
                965                 970                 975     


Glu Ser Ile Gln Asn Arg Gln Lys Ser Leu Arg Ala Ser Phe His Asn 
            980                 985                 990         


Leu Ser Arg Gly Glu Ala Asn Val  Leu Glu Lys Leu Ala  Cys Leu Ser 
        995                 1000                 1005             


Pro Val  Glu Ile Arg Thr Ile  Leu Phe Arg Tyr Phe  Asn Lys Val 
    1010                 1015                 1020             


Val Asn  Leu Arg Glu Ala Glu  Arg Lys Gln Gln Leu  Tyr Asn Glu 
    1025                 1030                 1035             


Glu Met  Lys Met Lys Val Leu  Glu Arg Asp Asn Met  Val Arg Glu 
    1040                 1045                 1050             


Leu Glu  Ser Ala Leu Asp His  Leu Lys Leu Gln Cys  Asp Arg Arg 
    1055                 1060                 1065             


Leu Thr  Leu Gln Gln Lys Glu  His Glu Gln Lys Met  Gln Leu Leu 
    1070                 1075                 1080             


Leu His  His Phe Lys Glu Gln  Asp Gly Glu Gly Ile  Met Glu Thr 
    1085                 1090                 1095             


Phe Lys  Thr Tyr Glu Asp Lys  Ile Gln Gln Leu Glu  Lys Asp Leu 
    1100                 1105                 1110             


Tyr Phe  Tyr Lys Lys Thr Ser  Arg Asp His Lys Lys  Lys Leu Lys 
    1115                 1120                 1125             


Glu Leu  Val Gly Glu Ala Ile  Arg Arg Gln Leu Ala  Pro Ser Glu 
    1130                 1135                 1140             


Tyr Gln  Glu Ala Gly Asp Gly  Val Leu Lys Pro Glu  Gly Gly Gly 
    1145                 1150                 1155             


Met Leu  Ser Glu Glu Leu Lys  Trp Ala Ser Arg Pro  Glu Ser Met 
    1160                 1165                 1170             


Lys Leu  Ser Gly Arg Glu Arg  Glu Met Asp Ser Ser  Ala Ser Ser 
    1175                 1180                 1185             


Leu Arg  Thr Gln Pro Asn Pro  Gln Lys Leu Trp Glu  Asp Ile Pro 
    1190                 1195                 1200             


Glu Leu  Pro Pro Ile His Ser  Ser Leu Ala Pro Pro  Ser Gly His 
    1205                 1210                 1215             


Met Leu  Gly Asn Glu Asn Lys  Thr Glu Thr Asp Asp  Asn Gln Phe 
    1220                 1225                 1230             


Thr Lys  Ser His Ser Arg Leu  Ser Ser Gln Ile Gln  Val Val Gly 
    1235                 1240                 1245             


Asn Val  Gly Arg Leu His Gly  Val Thr Pro Val Lys  Leu Cys Arg 
    1250                 1255                 1260             


Lys Glu  Leu Arg Gln Ile Ser  Ala Leu Glu Leu Ser  Leu Arg Arg 
    1265                 1270                 1275             


Ser Ser  Leu Gly Val Gly Ile  Gly Ser Met Ala Ala  Asp Ser Ile 
    1280                 1285                 1290             


Glu Val  Ser Arg Lys Pro Arg  Asp Leu Lys Thr 
    1295                 1300                 


<210> 5602
<211> 300
<212> PRT
<213> Homo sapiens

<400> 5602
Met Glu Glu Glu Ala Ser Ser Pro Gly Leu Gly Cys Ser Lys Pro His 
1               5                   10                  15      


Leu Glu Lys Leu Thr Leu Gly Ile Thr Arg Ile Leu Glu Ser Ser Pro 
            20                  25                  30          


Gly Val Thr Glu Val Thr Ile Ile Glu Lys Pro Pro Ala Glu Arg His 
        35                  40                  45              


Met Ile Ser Ser Trp Glu Gln Lys Asn Asn Cys Val Met Pro Glu Asp 
    50                  55                  60                  


Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His Met Thr Trp Ser 
65                  70                  75                  80  


Val Lys Leu Asp Glu His Ile Ile Pro Leu Gly Ser Met Ala Ile Asn 
                85                  90                  95      


Ser Ile Ser Lys Leu Thr Gln Leu Thr Gln Ser Ser Met Tyr Ser Leu 
            100                 105                 110         


Pro Asn Ala Pro Thr Leu Ala Asp Leu Glu Asp Asp Thr His Glu Ala 
        115                 120                 125             


Ser Asp Asp Gln Pro Glu Lys Pro His Phe Asp Ser Arg Ser Val Ile 
    130                 135                 140                 


Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys Val Cys Leu Val Tyr 
145                 150                 155                 160 


Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr Glu Ile Trp Phe Leu 
                165                 170                 175     


Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp Thr Phe Thr Ala Tyr 
            180                 185                 190         


Tyr Arg Leu Leu Ile Thr His Leu Gly Leu Pro Gln Trp Gln Tyr Ala 
        195                 200                 205             


Phe Thr Ser Tyr Gly Ile Ser Pro Gln Ala Lys Gln Trp Phe Ser Met 
    210                 215                 220                 


Tyr Lys Pro Ile Thr Tyr Asn Thr Asn Leu Leu Thr Glu Glu Thr Asp 
225                 230                 235                 240 


Ser Phe Val Asn Lys Leu Asp Pro Ser Lys Val Phe Lys Ser Lys Asn 
                245                 250                 255     


Lys Ile Val Ile Pro Lys Lys Lys Gly Pro Val Gln Pro Ala Gly Gly 
            260                 265                 270         


Gln Lys Gly Pro Ser Gly Pro Ser Gly Pro Ser Thr Ser Ser Thr Ser 
        275                 280                 285             


Lys Ser Ser Ser Gly Ser Gly Asn Pro Thr Arg Lys 
    290                 295                 300 


<210> 5603
<211> 129
<212> PRT
<213> Homo sapiens

<400> 5603
Met Met Thr Asp Leu Lys Gln Ser His Ser Val Arg Leu Asn Asp Gly 
1               5                   10                  15      


Pro Phe Met Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Asp His Thr 
            20                  25                  30          


Pro Lys Ser Gln Ala Ala Glu Ala Thr Lys Val Ala Ile Asp Val Gly 
        35                  40                  45              


Phe Arg His Ile Asp Ser Ala Tyr Leu Tyr Gln Asn Glu Glu Glu Val 
    50                  55                  60                  


Gly Gln Ala Ile Trp Glu Lys Ile Ala Asp Gly Thr Val Lys Arg Glu 
65                  70                  75                  80  


Glu Ile Phe Tyr Thr Ile Lys Leu Trp Ala Thr Phe Phe Arg Ala Glu 
                85                  90                  95      


Leu Val His Pro Ala Leu Glu Arg Ser Leu Lys Lys Leu Gly Pro Asp 
            100                 105                 110         


Tyr Val Asp Leu Phe Ile Ile His Val Pro Phe Ala Met Lys Gly Ser 
        115                 120                 125             


Ser 
    


<210> 5604
<211> 418
<212> PRT
<213> Homo sapiens

<400> 5604
Met His Pro Glu Pro Ser Glu Pro Ala Thr Gly Gly Ala Ala Glu Leu 
1               5                   10                  15      


Asp Cys Ala Gln Glu Pro Gly Val Glu Glu Ser Ala Gly Asp His Gly 
            20                  25                  30          


Ser Ala Gly Arg Gly Gly Cys Lys Glu Glu Ile Asn Asp Pro Lys Glu 
        35                  40                  45              


Ile Cys Val Gly Ser Ser Asp Thr Ser Tyr His Ser Gln Gln Lys Gln 
    50                  55                  60                  


Ser Gly Asp Asn Gly Ser Gly Gly His Phe Ala His Pro Arg Glu Asp 
65                  70                  75                  80  


Arg Glu Asp Arg Gly Pro Arg Met Thr Lys Ser Ser Leu Gln Lys Leu 
                85                  90                  95      


Cys Lys Gln His Lys Leu Tyr Ile Thr Pro Ala Leu Asn Asp Thr Leu 
            100                 105                 110         


Tyr Leu His Phe Lys Gly Phe Asp Arg Ile Glu Asn Leu Glu Glu Tyr 
        115                 120                 125             


Thr Gly Leu Arg Cys Leu Trp Leu Gln Ser Asn Gly Ile Gln Lys Ile 
    130                 135                 140                 


Glu Asn Leu Glu Ala Gln Thr Glu Leu Arg Cys Leu Phe Leu Gln Met 
145                 150                 155                 160 


Asn Leu Leu Arg Lys Ile Glu Asn Leu Glu Pro Leu Gln Lys Leu Asp 
                165                 170                 175     


Ala Leu Asn Leu Ser Asn Asn Tyr Ile Lys Thr Ile Glu Asn Leu Ser 
            180                 185                 190         


Cys Leu Pro Val Leu Asn Thr Leu Gln Met Ala His Asn His Leu Glu 
        195                 200                 205             


Thr Val Glu Asp Ile Gln His Leu Gln Glu Cys Leu Arg Leu Cys Val 
    210                 215                 220                 


Leu Asp Leu Ser His Asn Lys Leu Ser Asp Pro Glu Ile Leu Ser Ile 
225                 230                 235                 240 


Leu Glu Ser Met Pro Asp Leu Arg Val Leu Asn Leu Met Gly Asn Pro 
                245                 250                 255     


Val Ile Arg Gln Ile Pro Asn Tyr Arg Arg Thr Val Thr Val Arg Leu 
            260                 265                 270         


Lys His Leu Thr Tyr Leu Asp Asp Arg Pro Val Phe Pro Lys Asp Arg 
        275                 280                 285             


Ala Cys Ala Glu Ala Trp Ala Arg Gly Gly Tyr Ala Ala Glu Lys Glu 
    290                 295                 300                 


Glu Arg Gln Gln Trp Glu Ser Arg Glu Arg Lys Lys Ile Thr Asp Ser 
305                 310                 315                 320 


Ile Glu Ala Leu Ala Met Ile Lys Gln Arg Ala Glu Glu Arg Lys Arg 
                325                 330                 335     


Gln Arg Glu Ser Gln Glu Arg Gly Glu Met Thr Ser Ser Asp Asp Gly 
            340                 345                 350         


Glu Asn Val Pro Ala Ser Ala Glu Gly Lys Glu Glu Pro Pro Gly Asp 
        355                 360                 365             


Arg Glu Thr Arg Gln Lys Met Glu Leu Phe Val Lys Glu Ser Phe Glu 
    370                 375                 380                 


Ala Lys Asp Glu Leu Cys Pro Glu Lys Pro Ser Gly Glu Glu Pro Pro 
385                 390                 395                 400 


Val Glu Ala Lys Arg Glu Asp Gly Asp Pro Ala Thr Val Thr Ala Cys 
                405                 410                 415     


Glu Gly 
        


<210> 5605
<211> 823
<212> PRT
<213> Homo sapiens

<400> 5605
Met Gly Lys Lys Arg Thr Lys Gly Lys Thr Val Pro Ile Asp Asp Ser 
1               5                   10                  15      


Ser Glu Thr Leu Glu Pro Val Cys Arg His Ile Arg Lys Gly Leu Glu 
            20                  25                  30          


Gln Gly Asn Leu Lys Lys Ala Leu Val Asn Val Glu Trp Asn Ile Cys 
        35                  40                  45              


Gln Asp Cys Lys Thr Asp Asn Lys Val Lys Asp Lys Ala Glu Glu Glu 
    50                  55                  60                  


Thr Glu Glu Lys Pro Ser Val Trp Leu Cys Leu Lys Cys Gly His Gln 
65                  70                  75                  80  


Gly Cys Gly Arg Asn Ser Gln Glu Gln His Ala Leu Lys His Tyr Leu 
                85                  90                  95      


Thr Pro Arg Ser Glu Pro His Cys Leu Val Leu Ser Leu Asp Asn Trp 
            100                 105                 110         


Ser Val Trp Cys Tyr Val Cys Asp Asn Glu Val Gln Tyr Cys Ser Ser 
        115                 120                 125             


Asn Gln Leu Gly Gln Val Val Asp Tyr Val Arg Lys Gln Ala Ser Ile 
    130                 135                 140                 


Thr Thr Pro Lys Pro Ala Glu Lys Asp Asn Gly Asn Ile Glu Leu Glu 
145                 150                 155                 160 


Asn Lys Lys Leu Glu Lys Glu Ser Lys Asn Glu Gln Glu Arg Glu Lys 
                165                 170                 175     


Lys Glu Asn Met Ala Lys Glu Asn Pro Pro Met Asn Ser Pro Cys Gln 
            180                 185                 190         


Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
        195                 200                 205             


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
    210                 215                 220                 


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
225                 230                 235                 240 


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
                245                 250                 255     


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
            260                 265                 270         


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
        275                 280                 285             


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
    290                 295                 300                 


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
305                 310                 315                 320 


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
                325                 330                 335     


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
            340                 345                 350         


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
        355                 360                 365             


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
    370                 375                 380                 


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
385                 390                 395                 400 


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
                405                 410                 415     


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
            420                 425                 430         


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
        435                 440                 445             


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
    450                 455                 460                 


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
465                 470                 475                 480 


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
                485                 490                 495     


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
            500                 505                 510         


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
        515                 520                 525             


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
    530                 535                 540                 


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
545                 550                 555                 560 


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
                565                 570                 575     


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
            580                 585                 590         


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
        595                 600                 605             


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
    610                 615                 620                 


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
625                 630                 635                 640 


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
                645                 650                 655     


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
            660                 665                 670         


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
        675                 680                 685             


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
    690                 695                 700                 


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
705                 710                 715                 720 


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
                725                 730                 735     


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
            740                 745                 750         


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
        755                 760                 765             


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
    770                 775                 780                 


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
785                 790                 795                 800 


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
                805                 810                 815     


Leu Phe Tyr Glu Arg Ile Leu 
            820             


<210> 5606
<211> 1067
<212> PRT
<213> Homo sapiens

<400> 5606
Met Asn Ser Met Asp Arg His Ile Gln Gln Thr Asn Asp Arg Leu Gln 
1               5                   10                  15      


Cys Ile Lys Gln His Leu Gln Asn Pro Ala Asn Phe His Asn Ala Ala 
            20                  25                  30          


Thr Glu Leu Leu Asp Trp Cys Gly Asp Pro Arg Ala Phe Gln Arg Pro 
        35                  40                  45              


Phe Glu Gln Ser Leu Met Gly Cys Leu Thr Val Val Ser Arg Val Ala 
    50                  55                  60                  


Ala Gln Gln Gly Phe Asp Leu Asp Leu Gly Tyr Arg Leu Leu Ala Val 
65                  70                  75                  80  


Cys Ala Ala Asn Arg Asp Lys Phe Thr Pro Lys Ser Ala Ala Leu Leu 
                85                  90                  95      


Ser Ser Trp Cys Glu Glu Leu Gly Arg Leu Leu Leu Leu Arg His Gln 
            100                 105                 110         


Lys Ser Arg Gln Ser Asp Pro Pro Gly Lys Leu Pro Met Gln Pro Pro 
        115                 120                 125             


Leu Ser Ser Met Ser Ser Met Lys Pro Thr Leu Ser His Ser Asp Gly 
    130                 135                 140                 


Ser Phe Pro Tyr Asp Ser Val Pro Trp Gln Gln Asn Thr Asn Gln Pro 
145                 150                 155                 160 


Pro Gly Ser Leu Ser Val Val Thr Thr Val Trp Gly Val Thr Asn Thr 
                165                 170                 175     


Ser Gln Ser Gln Val Leu Gly Asn Pro Met Ala Asn Ala Asn Asn Pro 
            180                 185                 190         


Met Asn Pro Gly Gly Asn Pro Met Ala Ser Gly Met Thr Thr Ser Asn 
        195                 200                 205             


Pro Gly Leu Asn Ser Pro Gln Phe Ala Gly Gln Gln Gln Gln Phe Ser 
    210                 215                 220                 


Ala Lys Ala Gly Pro Ala Gln Pro Tyr Ile Gln Gln Ser Met Tyr Gly 
225                 230                 235                 240 


Arg Pro Asn Tyr Pro Gly Ser Gly Gly Phe Gly Ala Ser Tyr Pro Gly 
                245                 250                 255     


Gly Pro Asn Ala Pro Ala Gly Met Gly Ile Pro Pro His Thr Arg Pro 
            260                 265                 270         


Pro Ala Asp Phe Thr Gln Pro Ala Ala Ala Ala Ala Ala Ala Ala Val 
        275                 280                 285             


Ala Ala Ala Ala Ala Thr Ala Thr Ala Thr Ala Thr Ala Thr Val Ala 
    290                 295                 300                 


Ala Leu Gln Glu Thr Gln Asn Lys Asp Ile Asn Gln Tyr Gly Pro Met 
305                 310                 315                 320 


Gly Pro Thr Gln Ala Tyr Asn Ser Gln Phe Met Asn Gln Pro Gly Pro 
                325                 330                 335     


Arg Gly Pro Ala Ser Met Gly Gly Ser Met Asn Pro Ala Ser Met Ala 
            340                 345                 350         


Ala Gly Met Thr Pro Ser Gly Met Ser Gly Pro Pro Met Gly Met Asn 
        355                 360                 365             


Gln Pro Arg Pro Pro Gly Ile Ser Pro Phe Gly Thr His Gly Gln Arg 
    370                 375                 380                 


Met Pro Gln Gln Thr Tyr Pro Gly Pro Arg Pro Gln Ser Leu Pro Ile 
385                 390                 395                 400 


Gln Asn Ile Lys Arg Pro Tyr Pro Gly Glu Pro Asn Tyr Gly Asn Gln 
                405                 410                 415     


Gln Tyr Gly Pro Asn Ser Gln Phe Pro Thr Gln Pro Gly Gln Tyr Pro 
            420                 425                 430         


Ala Pro Asn Pro Pro Arg Pro Leu Thr Ser Pro Asn Tyr Pro Gly Gln 
        435                 440                 445             


Arg Met Pro Ser Gln Pro Ser Ser Gly Gln Tyr Pro Pro Pro Thr Val 
    450                 455                 460                 


Asn Met Gly Gln Tyr Tyr Lys Pro Glu Gln Phe Asn Gly Gln Asn Asn 
465                 470                 475                 480 


Thr Phe Ser Gly Ser Ser Tyr Ser Asn Tyr Ser Gln Gly Asn Val Asn 
                485                 490                 495     


Arg Pro Pro Arg Pro Val Pro Val Ala Asn Tyr Pro His Ser Pro Val 
            500                 505                 510         


Pro Gly Asn Pro Thr Pro Pro Met Thr Pro Gly Ser Ser Ile Pro Pro 
        515                 520                 525             


Tyr Leu Ser Pro Ser Gln Asp Val Lys Pro Pro Phe Pro Pro Asp Ile 
    530                 535                 540                 


Lys Pro Asn Met Ser Ala Leu Pro Pro Pro Pro Ala Asn His Asn Asp 
545                 550                 555                 560 


Glu Leu Arg Leu Thr Phe Pro Val Arg Asp Gly Val Val Leu Glu Pro 
                565                 570                 575     


Phe Arg Leu Glu His Asn Leu Ala Val Ser Asn His Val Phe His Leu 
            580                 585                 590         


Arg Pro Thr Val His Gln Thr Leu Met Trp Arg Ser Asp Leu Glu Leu 
        595                 600                 605             


Gln Phe Lys Cys Tyr His His Glu Asp Arg Gln Met Asn Thr Asn Trp 
    610                 615                 620                 


Pro Ala Ser Val Gln Val Ser Val Asn Ala Thr Pro Leu Thr Ile Glu 
625                 630                 635                 640 


Arg Gly Asp Asn Lys Thr Ser His Lys Pro Leu His Leu Lys His Val 
                645                 650                 655     


Cys Gln Pro Gly Arg Asn Thr Ile Gln Ile Thr Val Thr Ala Cys Cys 
            660                 665                 670         


Cys Ser His Leu Phe Val Leu Gln Leu Val His Arg Pro Ser Val Arg 
        675                 680                 685             


Ser Val Leu Gln Gly Leu Leu Lys Lys Arg Leu Leu Pro Ala Glu His 
    690                 695                 700                 


Cys Ile Thr Lys Ile Lys Arg Asn Phe Ser Ser Val Ala Ala Ser Ser 
705                 710                 715                 720 


Gly Asn Thr Thr Leu Asn Gly Glu Asp Gly Val Glu Gln Thr Ala Ile 
                725                 730                 735     


Lys Val Ser Leu Lys Cys Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro 
            740                 745                 750         


Ala Arg Gly His Asp Cys Lys His Val Gln Cys Phe Asp Leu Glu Ser 
        755                 760                 765             


Tyr Leu Gln Leu Asn Cys Glu Arg Gly Thr Trp Arg Cys Pro Val Cys 
    770                 775                 780                 


Asn Lys Thr Ala Leu Leu Glu Gly Leu Glu Val Asp Gln Tyr Met Trp 
785                 790                 795                 800 


Gly Ile Leu Asn Ala Ile Gln His Ser Glu Phe Glu Glu Val Thr Ile 
                805                 810                 815     


Asp Pro Thr Cys Ser Trp Arg Pro Val Pro Ile Lys Ser Asp Leu His 
            820                 825                 830         


Ile Lys Asp Asp Pro Asp Gly Ile Pro Ser Lys Arg Phe Lys Thr Met 
        835                 840                 845             


Ser Pro Ser Gln Met Ile Met Pro Asn Val Met Glu Met Ile Ala Ala 
    850                 855                 860                 


Leu Gly Pro Gly Pro Ser Pro Tyr Pro Leu Pro Pro Pro Pro Gly Gly 
865                 870                 875                 880 


Thr Asn Ser Asn Asp Tyr Ser Ser Gln Gly Asn Asn Tyr Gln Gly His 
                885                 890                 895     


Gly Asn Phe Asp Phe Pro His Gly Asn Pro Gly Gly Thr Ser Met Asn 
            900                 905                 910         


Asp Phe Met His Gly Pro Pro Gln Leu Ser His Pro Pro Asp Met Pro 
        915                 920                 925             


Asn Asn Met Ala Ala Leu Glu Lys Pro Leu Ser His Pro Met Gln Glu 
    930                 935                 940                 


Thr Met Pro His Ala Gly Ser Ser Asp Gln Pro His Pro Ser Ile Gln 
945                 950                 955                 960 


Gln Gly Leu His Val Pro His Pro Ser Ser Gln Ser Gly Pro Pro Leu 
                965                 970                 975     


His His Ser Gly Ala Pro Pro Pro Pro Pro Ser Gln Pro Pro Arg Gln 
            980                 985                 990         


Pro Pro Gln Ala Ala Pro Ser Ser  His Pro His Ser Asp  Leu Thr Phe 
        995                 1000                 1005             


Asn Pro  Ser Ser Ala Leu Glu  Gly Gln Ala Gly Ala  Gln Gly Ala 
    1010                 1015                 1020             


Ser Asp  Met Pro Glu Pro Ser  Leu Asp Leu Leu Pro  Glu Leu Thr 
    1025                 1030                 1035             


Asn Pro  Asp Glu Leu Leu Ser  Tyr Leu Asp Pro Pro  Asp Leu Pro 
    1040                 1045                 1050             


Ser Asn  Ser Asn Asp Asp Leu  Leu Ser Leu Phe Glu  Asn Asn 
    1055                 1060                 1065         


<210> 5607
<211> 345
<212> PRT
<213> Homo sapiens

<400> 5607
Met Asp Gly Glu Asp Ile Pro Asp Phe Ser Ser Leu Lys Glu Glu Thr 
1               5                   10                  15      


Ala Tyr Trp Lys Glu Leu Ser Leu Lys Tyr Lys Gln Ser Phe Gln Glu 
            20                  25                  30          


Ala Arg Asp Glu Leu Val Glu Phe Gln Glu Gly Ser Arg Glu Leu Glu 
        35                  40                  45              


Ala Glu Leu Glu Ala Gln Leu Val Gln Ala Glu Gln Arg Asn Arg Asp 
    50                  55                  60                  


Leu Gln Ala Asp Asn Gln Arg Leu Lys Tyr Glu Val Glu Ala Leu Lys 
65                  70                  75                  80  


Glu Lys Leu Glu His Gln Tyr Ala Gln Ser Tyr Lys Gln Val Ser Val 
                85                  90                  95      


Leu Glu Asp Asp Leu Ser Gln Thr Arg Ala Ile Lys Glu Gln Leu His 
            100                 105                 110         


Lys Tyr Val Arg Glu Leu Glu Gln Ala Asn Asp Asp Leu Glu Arg Ala 
        115                 120                 125             


Lys Arg Ala Thr Ile Val Ser Leu Glu Asp Phe Glu Gln Arg Leu Asn 
    130                 135                 140                 


Gln Ala Ile Glu Arg Asn Ala Phe Leu Glu Ser Glu Leu Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Leu Leu Val Ser Val Gln Arg Leu Lys Asp Glu Ala Arg Asp 
                165                 170                 175     


Leu Arg Gln Glu Leu Ala Val Arg Glu Arg Gln Gln Glu Val Thr Arg 
            180                 185                 190         


Lys Ser Ala Pro Ser Ser Pro Thr Leu Asp Cys Glu Lys Met Asp Ser 
        195                 200                 205             


Ala Val Gln Ala Ser Leu Ser Leu Pro Ala Thr Pro Val Gly Lys Gly 
    210                 215                 220                 


Thr Glu Asn Thr Phe Pro Ser Pro Lys Ala Ile Pro Asn Gly Phe Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Thr Pro Ser Ala Arg Ile Ser Ala Leu Asn Ile Val 
                245                 250                 255     


Gly Asp Leu Leu Arg Lys Val Gly Ala Leu Glu Ser Lys Leu Ala Ala 
            260                 265                 270         


Cys Arg Asn Phe Ala Lys Asp Gln Ala Ser Arg Lys Ser Tyr Ile Ser 
        275                 280                 285             


Gly Asn Val Asn Cys Gly Val Leu Asn Gly Asn Gly Thr Lys Phe Ser 
    290                 295                 300                 


Arg Ser Gly His Thr Ser Phe Phe Asp Lys Gly Ala Val Asn Gly Phe 
305                 310                 315                 320 


Asp Pro Ala Pro Pro Pro Pro Gly Leu Gly Ser Ser Arg Pro Ser Ser 
                325                 330                 335     


Ala Pro Gly Met Leu Pro Leu Ser Val 
            340                 345 


<210> 5608
<211> 195
<212> PRT
<213> Homo sapiens

<400> 5608
Met Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         


Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu 
        115                 120                 125             


Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly 
    130                 135                 140                 


Val Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile 
145                 150                 155                 160 


Gln Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe 
                165                 170                 175     


Val Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg 
            180                 185                 190         


Phe Leu His 
        195 


<210> 5609
<211> 259
<212> PRT
<213> Homo sapiens

<400> 5609
Met Ala Asp Ala Cys Cys Thr Arg Thr Tyr Val Ile Ala Ala Ser Thr 
1               5                   10                  15      


Met Ser Val Cys Ser Ser Asp Val Gly His Val Ser Arg Val Ser Ser 
            20                  25                  30          


Pro Ser Thr Cys Thr Gly Ser Ser Trp Gln Val Asp Asn Cys Gln Glu 
        35                  40                  45              


Ser Cys Cys Glu Pro Arg Ser Cys Ala Ser Ser Cys Cys Thr Pro Ser 
    50                  55                  60                  


Cys Cys Ala Pro Ala Pro Cys Leu Ala Leu Val Cys Ala Pro Val Ser 
65                  70                  75                  80  


Cys Glu Pro Ser Pro Cys Gln Ser Gly Cys Thr Asp Ser Cys Thr Pro 
                85                  90                  95      


Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser 
            100                 105                 110         


Pro Cys Gln Gln Ala Cys Cys Val Pro Val Cys Cys Lys Ser Asn Cys 
        115                 120                 125             


Cys Lys Pro Val Cys Cys Val Ser Ile Cys Ser Gly Ala Ser Ser Pro 
    130                 135                 140                 


Cys Cys Gln Gln Ser Ser Cys Gln Ser Ala Cys Cys Thr Phe Ser Pro 
145                 150                 155                 160 


Cys Gln Gln Ala Cys Cys Val Pro Ile Cys Cys Lys Pro Ile Cys Cys 
                165                 170                 175     


Val Pro Val Cys Ser Gly Ala Ser Ser Leu Cys Cys Gln Lys Ser Ser 
            180                 185                 190         


Cys Gln Pro Ala Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser Ser Ser 
        195                 200                 205             


Val Ser Leu Leu Cys Arg Pro Val Cys Arg Pro Ala Cys Cys Val Pro 
    210                 215                 220                 


Val Pro Ser Cys Cys Val Pro Ala Ser Ser Cys Gln Pro Ser Cys Cys 
225                 230                 235                 240 


His Pro Ala Ser Cys Leu Ser Phe Leu Cys Arg Pro Ala Cys Ser Arg 
                245                 250                 255     


Leu Ala Cys 
            


<210> 5610
<211> 56
<212> PRT
<213> Homo sapiens

<400> 5610
Met Ile Tyr Tyr Ser Asn Tyr Tyr Gly Gly Tyr Gly Tyr Gly Gly Leu 
1               5                   10                  15      


Gly Cys Gly Tyr Gly Cys Gly Tyr Arg Gly Tyr Gly Cys Gly Tyr Gly 
            20                  25                  30          


Gly Tyr Gly Gly Tyr Gly Asn Gly Tyr Tyr Cys Pro Ser Cys Tyr Gly 
        35                  40                  45              


Arg Tyr Trp Ser Tyr Gly Phe Tyr 
    50                  55      


<210> 5611
<211> 298
<212> PRT
<213> Homo sapiens

<400> 5611
Met Ala Ala Ser Thr Met Ser Val Cys Ser Ser Ala Tyr Ser Asp Ser 
1               5                   10                  15      


Trp Gln Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Ser 
            20                  25                  30          


Ala Pro Ser Cys Cys Ala Pro Ala Pro Ser Leu Ser Leu Val Cys Thr 
        35                  40                  45              


Pro Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro 
    50                  55                  60                  


Ser Ala Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys 
65                  70                  75                  80  


Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln 
                85                  90                  95      


Gln Ala Cys Cys Val Pro Val Cys Cys Lys Thr Val Cys Cys Lys Pro 
            100                 105                 110         


Val Cys Cys Val Pro Val Cys Cys Gly Ala Ala Ser Ser Cys Cys Arg 
        115                 120                 125             


Gln Ser Ser Cys Gln Pro Ala Cys Cys Ala Ser Ser Ser Cys Gln Pro 
    130                 135                 140                 


Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Val Ser Thr 
145                 150                 155                 160 


Cys Ser Glu Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro 
                165                 170                 175     


Ala Cys Cys Thr Ser Ser Ser Tyr Gln Gln Ala Cys Cys Val Pro Val 
            180                 185                 190         


Cys Cys Lys Thr Val Tyr Cys Lys Pro Ile Cys Cys Val Pro Val Cys 
        195                 200                 205             


Ser Arg Ala Ser Ser Ser Arg Cys Gln Gln Pro Ser Cys Gln Pro Ala 
    210                 215                 220                 


Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu 
225                 230                 235                 240 


Cys His Pro Val Cys Arg Ser Thr Cys Cys Val Pro Val Ser Ser Cys 
                245                 250                 255     


Cys Ala Pro Thr Ser Ser Cys Gln Ser Ser Cys Cys Arg Pro Ala Ser 
            260                 265                 270         


Cys Val Ser Leu Leu Cys Arg Pro Ala Ser Ser Arg Leu Ala Cys Tyr 
        275                 280                 285             


Ser Leu Cys Ser Gly Lys Lys Ser Ser Cys 
    290                 295             


<210> 5612
<211> 188
<212> PRT
<213> Homo sapiens

<400> 5612
Met Thr Ala Pro Ser Cys Ala Phe Pro Val Gln Phe Arg Gln Pro Ser 
1               5                   10                  15      


Val Ser Gly Leu Ser Gln Ile Thr Lys Ser Leu Tyr Ile Ser Asn Gly 
            20                  25                  30          


Val Ala Ala Asn Asn Lys Leu Met Leu Ser Ser Asn Gln Ile Thr Met 
        35                  40                  45              


Val Ile Asn Val Ser Val Glu Val Val Asn Thr Leu Tyr Glu Asp Ile 
    50                  55                  60                  


Gln Tyr Met Gln Val Pro Val Ala Asp Ser Pro Asn Ser Arg Leu Cys 
65                  70                  75                  80  


Asp Phe Phe Asp Pro Ile Ala Asp His Ile His Ser Val Glu Met Lys 
                85                  90                  95      


Gln Gly Arg Thr Leu Leu His Cys Ala Ala Gly Val Ser Arg Ser Ala 
            100                 105                 110         


Ala Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ala Met Ser Leu Leu 
        115                 120                 125             


Asp Ala His Thr Trp Thr Lys Ser Cys Arg Pro Ile Ile Arg Pro Asn 
    130                 135                 140                 


Ser Gly Phe Trp Glu Gln Leu Ile His Tyr Glu Phe Gln Leu Phe Gly 
145                 150                 155                 160 


Lys Asn Thr Val His Met Val Ser Ser Pro Val Gly Met Ile Pro Asp 
                165                 170                 175     


Ile Tyr Glu Lys Glu Val Arg Leu Met Ile Pro Leu 
            180                 185             


<210> 5613
<211> 48
<212> PRT
<213> Homo sapiens

<400> 5613
Met Ser Phe Asp Asn Asn Tyr His Gly Gly Gln Gly Tyr Ala Lys Gly 
1               5                   10                  15      


Gly Leu Gly Cys Ser Tyr Gly Cys Gly Leu Ser Gly Tyr Gly Tyr Ala 
            20                  25                  30          


Cys Tyr Cys Pro Trp Cys Tyr Glu Arg Ser Trp Phe Ser Gly Cys Phe 
        35                  40                  45              


<210> 5614
<211> 63
<212> PRT
<213> Homo sapiens

<400> 5614
Met Ser Tyr Ser Gly Ser Tyr Tyr Gly Gly Leu Gly Tyr Gly Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Tyr Ser Cys Gly Cys Gly Ser Phe 
            20                  25                  30          


Arg Arg Leu Gly Tyr Gly Cys Gly Tyr Gly Gly Tyr Arg Tyr Ser Cys 
        35                  40                  45              


Cys His Pro Ser Cys Tyr Gly Gly Tyr Trp Ser Ser Gly Phe Tyr 
    50                  55                  60              


<210> 5615
<211> 62
<212> PRT
<213> Homo sapiens

<400> 5615
Met Cys Gly Ser Tyr Tyr Gly Asn Tyr Tyr Gly Asp His Gly Tyr Gly 
1               5                   10                  15      


Cys Cys Gly Tyr Glu Gly Leu Gly Tyr Gly Tyr Gly Ser Leu Arg Cys 
            20                  25                  30          


Gly Tyr Ser Ser Cys Cys Gly Tyr Gly His Gly Tyr Gly Ser Arg Phe 
        35                  40                  45              


Phe Cys Gly Cys Gly Tyr Gly Cys Gly Ser Gly Tyr Tyr Tyr 
    50                  55                  60          


<210> 5616
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 5616
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His Val Arg Thr Arg 
            820                 825                 830         


Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser Val Phe 
        835                 840                 845             


Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala Gln Trp Gln Arg 
    850                 855                 860                 


Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn Tyr Met Thr Gln 
865                 870                 875                 880 


Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp Pro Leu Ser Glu 
                885                 890                 895     


Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Val Lys Gly Val 
            900                 905                 910         


Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe Arg Pro Ala Ser 
        915                 920                 925             


Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser Met Glu Asn Leu 
    930                 935                 940                 


Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala Leu Gln Thr Ser 
945                 950                 955                 960 


Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg Ser Pro Leu Ile 
                965                 970                 975     


Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser Glu Thr Ser Ser 
            980                 985                 990         


Ser Arg Pro Gly Gly Tyr Arg Leu  Phe Ser Ser Ser Arg  Pro Pro Thr 
        995                 1000                 1005             


Glu Met  Lys Gln Ser Gly Leu  Gly Ser Gln Cys Thr  Gly Leu Phe 
    1010                 1015                 1020             


Ser Thr  Thr Val Leu Gly Gly  Ser Ser Ser Ala Pro  Asn Leu Gln 
    1025                 1030                 1035             


Asp Tyr  Ala Arg Ser His Gly  Lys Lys Leu Pro Pro  Ala Ser Leu 
    1040                 1045                 1050             


Lys His  Arg Asp Gly Phe Glu  Gly Cys Ser Met Val  Pro Thr Ile 
    1055                 1060                 1065             


Tyr Pro  Leu Glu Thr Leu His  Asn Ala Leu Ser Leu  Arg Gln Val 
    1070                 1075                 1080             


Ser Glu  Phe Leu Ser Arg Val  Cys Gln Arg His Thr  Asp Ala Gln 
    1085                 1090                 1095             


Ala Gln  Ala Ser Ala Ala Leu  Phe Asp Ser Met His  Ser Ser Gln 
    1100                 1105                 1110             


Ala Ser  Asp Asn Pro Phe Ser  Pro Pro Arg Thr Leu  His Ser Pro 
    1115                 1120                 1125             


Pro Leu  Gln Leu Gln Gln Arg  Ser Glu Lys Pro Pro  Trp Tyr Ser 
    1130                 1135                 1140             


Ser Gly  Pro Ser Ser Thr Val  Ser Ser Ala Gly Pro  Ser Ser Pro 
    1145                 1150                 1155             


Thr Thr  Val Asp Gly Asn Ser  Gln Phe Gly Phe Ser  Asp Gln Pro 
    1160                 1165                 1170             


Ser Leu  Asn Ser His Val Ala  Glu Glu His Gln Gly  Leu Gly Leu 
    1175                 1180                 1185             


Leu Gln  Glu Thr Pro Gly Ser  Gly Ala Gln Glu Leu  Ser Ile Glu 
    1190                 1195                 1200             


Gly Glu  Gln Glu Leu Phe Glu  Pro Asn Gln Ser Pro  Gln Val Pro 
    1205                 1210                 1215             


Pro Met  Glu Thr Ser Gln Pro  Tyr Glu Glu Val Ser  Gln Pro Cys 
    1220                 1225                 1230             


Gln Glu  Val Pro Asp Ile Ser  Gln Pro Cys Gln Asp  Ile Ser Glu 
    1235                 1240                 1245             


Ala Leu  Ser Gln Pro Cys Gln  Lys Val Pro Asp Ile  Ser Gln Gln 
    1250                 1255                 1260             


Cys Gln  Glu Asn His Asp Asn  Gly Asn His Thr Cys  Gln Glu Val 
    1265                 1270                 1275             


Pro His  Ile Ser Gln Pro Cys  Gln Lys Ser Ser Gln  Leu Cys Gln 
    1280                 1285                 1290             


Lys Val  Ser Glu Glu Val Cys  Gln Leu Cys Leu Glu  Asn Ser Glu 
    1295                 1300                 1305             


Glu Val  Ser Gln Pro Cys Gln  Gly Val Ser Val Glu  Val Gly Lys 
    1310                 1315                 1320             


Leu Val  His Lys Phe His Val  Gly Val Gly Ser Leu  Val Gln Glu 
    1325                 1330                 1335             


Thr Leu  Val Glu Val Gly Ser  Pro Ala Glu Glu Ile  Pro Glu Glu 
    1340                 1345                 1350             


Val Ile  Gln Pro Tyr Gln Glu  Phe Ser Val Glu Val  Gly Arg Leu 
    1355                 1360                 1365             


Ala Gln  Glu Thr Ser Ala Ile  Asn Leu Leu Ser Gln  Gly Ile Pro 
    1370                 1375                 1380             


Glu Ile  Asp Lys Pro Ser Gln  Glu Phe Pro Glu Glu  Ile Asp Leu 
    1385                 1390                 1395             


Gln Ala  Gln Glu Val Pro Glu  Glu Ile Asn 
    1400                 1405             


<210> 5617
<211> 234
<212> PRT
<213> Homo sapiens

<400> 5617
Met Glu Gly Ala Ser Arg Asn Leu Ala Ser Thr Pro Arg Val His Ala 
1               5                   10                  15      


Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala 
            20                  25                  30          


Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val 
        35                  40                  45              


Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro 
    50                  55                  60                  


Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys 
65                  70                  75                  80  


Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr 
                85                  90                  95      


Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro 
            100                 105                 110         


Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg 
        115                 120                 125             


Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr 
    130                 135                 140                 


Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser 
145                 150                 155                 160 


Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu 
                165                 170                 175     


Val Phe Val Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met 
            180                 185                 190         


Ala Leu Asn Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro 
        195                 200                 205             


Gln Asp Ser Ser Asp Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His 
    210                 215                 220                 


Lys His Cys Gly Thr Pro Val His Ser Ser 
225                 230                 


<210> 5618
<211> 178
<212> PRT
<213> Homo sapiens

<400> 5618
Met Thr Thr Leu Arg Ala Phe Thr Cys Asp Asp Leu Phe Arg Phe Asn 
1               5                   10                  15      


Asn Ile Asn Leu Asp Pro Leu Thr Glu Thr Tyr Gly Ile Pro Phe Tyr 
            20                  25                  30          


Leu Gln Tyr Leu Ala His Trp Pro Glu Tyr Phe Ile Val Ala Glu Ala 
        35                  40                  45              


Pro Gly Gly Glu Leu Met Gly Tyr Ile Met Gly Lys Ala Glu Gly Ser 
    50                  55                  60                  


Val Ala Arg Glu Glu Trp His Gly His Val Thr Ala Leu Ser Val Ala 
65                  70                  75                  80  


Pro Glu Phe Arg Arg Leu Gly Leu Ala Ala Lys Leu Met Glu Leu Leu 
                85                  90                  95      


Glu Glu Ile Ser Glu Arg Lys Gly Gly Phe Phe Val Asp Leu Phe Val 
            100                 105                 110         


Arg Val Ser Asn Gln Val Ala Val Asn Met Tyr Lys Gln Leu Gly Tyr 
        115                 120                 125             


Ser Val Tyr Arg Thr Val Ile Glu Tyr Tyr Ser Ala Ser Asn Gly Glu 
    130                 135                 140                 


Pro Asp Glu Asp Ala Tyr Asp Met Arg Lys Ala Leu Ser Arg Asp Thr 
145                 150                 155                 160 


Glu Lys Lys Ser Ile Ile Pro Leu Pro His Pro Val Arg Pro Glu Asp 
                165                 170                 175     


Ile Glu 
        


<210> 5619
<211> 790
<212> PRT
<213> Homo sapiens

<400> 5619
Met Gly Thr Arg Lys Lys Val His Ala Phe Val Arg Val Lys Pro Thr 
1               5                   10                  15      


Asp Asp Phe Ala His Glu Met Ile Arg Tyr Gly Asp Asp Lys Arg Ser 
            20                  25                  30          


Ile Asp Ile His Leu Lys Lys Asp Ile Arg Arg Gly Val Val Asn Asn 
        35                  40                  45              


Gln Gln Thr Asp Trp Ser Phe Lys Leu Asp Gly Val Leu His Asp Ala 
    50                  55                  60                  


Ser Gln Asp Leu Val Tyr Glu Thr Val Ala Lys Asp Val Val Ser Gln 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Gly Thr Ile Met Cys Tyr Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Lys Thr Tyr Thr Met Met Gly Ala Thr Glu Asn Tyr Lys His 
            100                 105                 110         


Arg Gly Ile Leu Pro Arg Ala Leu Gln Gln Val Phe Arg Met Ile Glu 
        115                 120                 125             


Glu Arg Pro Thr His Ala Ile Thr Val Arg Val Ser Tyr Leu Glu Ile 
    130                 135                 140                 


Tyr Asn Glu Ser Leu Phe Asp Leu Leu Ser Thr Leu Pro Tyr Val Gly 
145                 150                 155                 160 


Pro Ser Val Thr Pro Met Thr Ile Val Glu Asn Pro Gln Gly Val Phe 
                165                 170                 175     


Ile Lys Gly Leu Ser Val His Leu Thr Ser Gln Glu Glu Asp Ala Phe 
            180                 185                 190         


Ser Leu Leu Phe Glu Gly Glu Thr Asn Arg Ile Ile Ala Ser His Thr 
        195                 200                 205             


Met Asn Lys Asn Ser Ser Arg Ser His Cys Ile Phe Thr Ile Tyr Leu 
    210                 215                 220                 


Glu Ala His Ser Arg Thr Leu Ser Glu Glu Lys Tyr Ile Thr Ser Lys 
225                 230                 235                 240 


Ile Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Gly Lys Ser Gly 
                245                 250                 255     


Ser Glu Gly Gln Val Leu Lys Glu Ala Thr Tyr Ile Asn Lys Ser Leu 
            260                 265                 270         


Ser Phe Leu Glu Gln Ala Ile Ile Ala Leu Gly Asp Gln Lys Arg Asp 
        275                 280                 285             


His Ile Pro Phe Arg Gln Cys Lys Leu Thr His Ala Leu Lys Asp Ser 
    290                 295                 300                 


Leu Gly Gly Asn Cys Asn Met Val Leu Val Thr Asn Ile Tyr Gly Glu 
305                 310                 315                 320 


Ala Ala Gln Leu Glu Glu Thr Leu Ser Ser Leu Arg Phe Ala Ser Arg 
                325                 330                 335     


Met Lys Leu Val Thr Thr Glu Pro Ala Ile Asn Glu Lys Tyr Asp Ala 
            340                 345                 350         


Glu Arg Met Val Lys Asn Leu Glu Lys Glu Leu Ala Leu Leu Lys Gln 
        355                 360                 365             


Glu Leu Ala Ile His Asp Ser Leu Thr Asn Arg Thr Phe Val Thr Tyr 
    370                 375                 380                 


Asp Pro Met Asp Glu Ile Gln Ile Ala Glu Ile Asn Ser Gln Val Arg 
385                 390                 395                 400 


Arg Tyr Leu Glu Gly Thr Leu Asp Glu Ile Asp Ile Ile Ser Leu Arg 
                405                 410                 415     


Gln Ile Lys Glu Val Phe Asn Gln Phe Arg Val Val Leu Ser Gln Gln 
            420                 425                 430         


Glu Gln Glu Val Glu Ser Thr Leu Arg Arg Lys Tyr Thr Leu Ile Asp 
        435                 440                 445             


Arg Asn Asp Phe Ala Ala Ile Ser Ala Ile Gln Lys Ala Gly Leu Val 
    450                 455                 460                 


Asp Val Asp Gly His Leu Val Gly Glu Pro Glu Gly Gln Asn Phe Gly 
465                 470                 475                 480 


Leu Gly Val Ala Pro Phe Ser Thr Lys Pro Gly Lys Lys Ala Lys Ser 
                485                 490                 495     


Lys Lys Thr Phe Lys Glu Pro Leu Ser Ser Leu Ala Arg Lys Glu Gly 
            500                 505                 510         


Ala Ser Ser Pro Val Asn Gly Lys Asp Leu Asp Tyr Val Ser Thr Ser 
        515                 520                 525             


Lys Thr Gln Leu Val Pro Ser Ser Lys Asp Gly Asp Val Lys Asp Met 
    530                 535                 540                 


Leu Ser Arg Asp Arg Glu Thr Ser Ser Ile Glu Pro Leu Pro Ser Asp 
545                 550                 555                 560 


Ser Pro Lys Glu Glu Leu Arg Pro Ile Arg Pro Asp Thr Pro Pro Ser 
                565                 570                 575     


Lys Pro Val Ala Phe Glu Glu Phe Lys Asn Glu Gln Gly Ser Glu Ile 
            580                 585                 590         


Asn Arg Ile Phe Lys Glu Asn Lys Ser Ile Leu Asn Glu Arg Arg Lys 
        595                 600                 605             


Arg Ala Ser Glu Thr Thr Gln His Ile Asn Ala Ile Lys Arg Glu Ile 
    610                 615                 620                 


Asp Val Thr Lys Glu Ala Leu Asn Phe Gln Lys Ser Leu Arg Glu Lys 
625                 630                 635                 640 


Gln Gly Lys Tyr Glu Asn Lys Gly Leu Met Ile Ile Asp Glu Glu Glu 
                645                 650                 655     


Phe Leu Leu Ile Leu Lys Leu Lys Asp Leu Lys Lys Gln Tyr Arg Ser 
            660                 665                 670         


Glu Tyr Gln Asp Leu Arg Asp Leu Arg Ala Glu Ile Gln Tyr Cys Gln 
        675                 680                 685             


His Leu Val Asp Gln Cys Arg His Arg Leu Leu Met Glu Phe Asp Ile 
    690                 695                 700                 


Trp Tyr Asn Glu Ser Phe Val Ile Pro Glu Asp Met Gln Met Ala Leu 
705                 710                 715                 720 


Lys Pro Gly Gly Ser Ile Arg Pro Gly Met Val Pro Val Asn Arg Ile 
                725                 730                 735     


Val Ser Leu Gly Glu Asp Asp Gln Asp Lys Phe Ser Gln Leu Gln Gln 
            740                 745                 750         


Arg Val Leu Pro Glu Gly Pro Asp Ser Ile Ser Phe Tyr Asn Ala Lys 
        755                 760                 765             


Val Lys Ile Glu Gln Lys His Asn Tyr Leu Lys Thr Met Met Gly Leu 
    770                 775                 780                 


Gln Gln Ala His Arg Lys 
785                 790 


<210> 5620
<211> 1195
<212> PRT
<213> Homo sapiens

<400> 5620
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Gly 
    130                 135                 140                 


Asp Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu 
145                 150                 155                 160 


Pro Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys 
                165                 170                 175     


Asn Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe 
            180                 185                 190         


Pro Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val 
        195                 200                 205             


Tyr Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe 
    210                 215                 220                 


Arg Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val 
225                 230                 235                 240 


Arg Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly 
                245                 250                 255     


Thr Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu 
            260                 265                 270         


Ala Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu 
        275                 280                 285             


Gly Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu 
    290                 295                 300                 


Val Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe 
305                 310                 315                 320 


Asp Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly 
                325                 330                 335     


Phe Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys 
            340                 345                 350         


Ile Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile 
        355                 360                 365             


Pro Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr 
    370                 375                 380                 


Thr Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg 
385                 390                 395                 400 


His Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His 
                405                 410                 415     


Pro Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly 
            420                 425                 430         


Lys Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile 
        435                 440                 445             


Thr Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile 
    450                 455                 460                 


Glu Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met 
465                 470                 475                 480 


Tyr Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr 
                485                 490                 495     


Pro His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu 
            500                 505                 510         


Thr Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu 
        515                 520                 525             


Thr Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg 
    530                 535                 540                 


Cys Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys 
545                 550                 555                 560 


Gly Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr 
                565                 570                 575     


Ala Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys 
            580                 585                 590         


Gly Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met 
        595                 600                 605             


Val Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser 
    610                 615                 620                 


Leu Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu 
625                 630                 635                 640 


Gln Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro 
                645                 650                 655     


Thr Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro 
            660                 665                 670         


Val Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His 
        675                 680                 685             


Gln Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu 
    690                 695                 700                 


Tyr His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu 
705                 710                 715                 720 


Glu Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile 
                725                 730                 735     


Pro Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser 
            740                 745                 750         


Leu Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu 
        755                 760                 765             


Ala Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys 
    770                 775                 780                 


Leu Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu 
785                 790                 795                 800 


Leu Asp Leu Gln Arg Thr His Glu Asp Glu Tyr Ser Arg Gly Val Leu 
                805                 810                 815     


Ser Pro Gly Arg His Val Arg Thr Arg Leu Tyr Phe Thr Ser Glu Ser 
            820                 825                 830         


His Val His Ser Leu Leu Ser Val Phe Arg Tyr Gly Gly Leu Leu Asp 
        835                 840                 845             


Glu Thr Gln Asp Ala Asp Arg Ala Leu Gln Thr Ser Pro Gln Pro Pro 
    850                 855                 860                 


Glu Gly Pro Gly Leu Pro Arg Arg Ser Pro Leu Ile Arg Asn Arg Lys 
865                 870                 875                 880 


Ala Gly Ser Met Glu Val Leu Ser Glu Thr Ser Ser Ser Arg Pro Gly 
                885                 890                 895     


Gly Tyr Arg Leu Phe Ser Ser Ser Arg Pro Pro Thr Glu Met Lys Gln 
            900                 905                 910         


Ser Gly Leu Gly Ser Gln Cys Thr Gly Leu Phe Ser Thr Thr Val Leu 
        915                 920                 925             


Gly Gly Ser Ser Ser Ala Pro Asn Leu Gln Asp Tyr Ala Arg Ser His 
    930                 935                 940                 


Gly Lys Lys Leu Pro Pro Ala Ser Leu Lys His Arg Asp Glu Leu Leu 
945                 950                 955                 960 


Phe Val Pro Ala Val Lys Arg Phe Ser Val Ser Phe Ala Lys His Pro 
                965                 970                 975     


Thr Asn Gly Phe Glu Gly Cys Ser Met Val Pro Thr Ile Tyr Pro Leu 
            980                 985                 990         


Glu Thr Leu His Asn Ala Leu Ser  Leu Arg Gln Val Pro  Pro Met Glu 
        995                 1000                 1005             


Thr Ser  Gln Pro Tyr Glu Glu  Val Ser Gln Pro Cys  Gln Glu Val 
    1010                 1015                 1020             


Pro Asp  Ile Ser Gln Pro Cys  Gln Asp Ile Ser Glu  Ala Leu Ser 
    1025                 1030                 1035             


Gln Pro  Cys Gln Lys Val Pro  Asp Ile Ser Gln Gln  Cys Gln Glu 
    1040                 1045                 1050             


Asn His  Asp Asn Gly Asn His  Thr Cys Gln Glu Val  Pro His Ile 
    1055                 1060                 1065             


Ser Gln  Pro Cys Gln Lys Ser  Ser Gln Leu Cys Gln  Lys Val Ser 
    1070                 1075                 1080             


Glu Glu  Val Cys Gln Leu Cys  Leu Glu Asn Ser Glu  Glu Val Ser 
    1085                 1090                 1095             


Gln Pro  Cys Gln Gly Val Ser  Val Glu Val Gly Lys  Leu Val His 
    1100                 1105                 1110             


Lys Phe  His Val Gly Val Gly  Ser Leu Val Gln Glu  Thr Leu Val 
    1115                 1120                 1125             


Glu Val  Gly Ser Pro Ala Glu  Glu Ile Pro Glu Glu  Val Ile Gln 
    1130                 1135                 1140             


Pro Tyr  Gln Glu Phe Ser Val  Glu Val Gly Arg Leu  Ala Gln Glu 
    1145                 1150                 1155             


Thr Ser  Ala Ile Asn Leu Leu  Ser Gln Gly Ile Pro  Glu Ile Asp 
    1160                 1165                 1170             


Lys Pro  Ser Gln Glu Phe Pro  Glu Glu Ile Asp Leu  Gln Ala Gln 
    1175                 1180                 1185             


Glu Val  Pro Glu Glu Ile Asn  
    1190                 1195 


<210> 5621
<211> 79
<212> PRT
<213> Homo sapiens

<400> 5621
Met Cys Cys Asn Tyr Tyr Gly Asn Ser Cys Gly Tyr Gly Ser Gly Cys 
1               5                   10                  15      


Gly Cys Gly Tyr Gly Ser Gly Ser Gly Cys Gly Cys Gly Tyr Gly Thr 
            20                  25                  30          


Gly Tyr Gly Cys Gly Tyr Gly Cys Gly Phe Gly Ser His Tyr Gly Cys 
        35                  40                  45              


Gly Tyr Gly Thr Gly Tyr Gly Cys Gly Tyr Gly Ser Gly Ser Gly Tyr 
    50                  55                  60                  


Cys Gly Tyr Arg Pro Phe Cys Phe Arg Arg Cys Tyr Ser Ser Cys 
65                  70                  75                  


<210> 5622
<211> 588
<212> PRT
<213> Homo sapiens

<400> 5622
Met Lys Leu Glu Phe Thr Glu Lys Asn Tyr Asn Ser Phe Val Leu Gln 
1               5                   10                  15      


Asn Leu Asn Arg Gln Arg Lys Arg Lys Glu Tyr Trp Asp Met Ala Leu 
            20                  25                  30          


Ser Val Asp Asn His Val Phe Phe Ala His Arg Asn Val Leu Ala Ala 
        35                  40                  45              


Val Ser Pro Leu Val Arg Ser Leu Ile Ser Ser Asn Asp Met Lys Thr 
    50                  55                  60                  


Ala Asp Glu Leu Phe Ile Thr Ile Asp Thr Ser Tyr Leu Ser Pro Val 
65                  70                  75                  80  


Thr Val Asp Gln Leu Leu Asp Tyr Phe Tyr Ser Gly Lys Val Val Ile 
                85                  90                  95      


Ser Glu Gln Asn Val Glu Glu Leu Leu Arg Gly Ala Gln Tyr Phe Asn 
            100                 105                 110         


Thr Pro Arg Leu Arg Val His Cys Asn Asp Phe Leu Ile Lys Ser Ile 
        115                 120                 125             


Cys Arg Ala Asn Cys Leu Arg Tyr Leu Phe Leu Ala Glu Leu Phe Glu 
    130                 135                 140                 


Leu Lys Glu Val Ser Asp Val Ala Tyr Ser Gly Ile Arg Asp Asn Phe 
145                 150                 155                 160 


His Tyr Trp Ala Ser Pro Glu Gly Ser Met His Phe Met Arg Cys Pro 
                165                 170                 175     


Pro Val Ile Phe Gly Arg Leu Leu Arg Asp Glu Asn Leu His Val Leu 
            180                 185                 190         


Asn Glu Asp Gln Ala Leu Ser Ala Leu Ile Asn Trp Val Tyr Phe Arg 
        195                 200                 205             


Lys Glu Asp Arg Glu Lys Tyr Phe Lys Lys Phe Phe Asn Tyr Ile Asn 
    210                 215                 220                 


Leu Asn Ala Val Ser Asn Lys Thr Leu Val Phe Ala Ser Asn Lys Leu 
225                 230                 235                 240 


Val Gly Met Glu Asn Thr Ser Ser His Thr Thr Leu Ile Glu Ser Val 
                245                 250                 255     


Leu Met Asp Arg Lys Gln Glu Arg Pro Cys Ser Leu Leu Val Tyr Gln 
            260                 265                 270         


Arg Lys Gly Ala Leu Leu Asp Ser Val Val Ile Leu Gly Gly Gln Lys 
        275                 280                 285             


Ala His Gly Gln Phe Asn Asp Gly Val Phe Ala Tyr Ile Ile Gln Glu 
    290                 295                 300                 


Asn Leu Trp Met Lys Leu Ser Asp Met Pro Tyr Arg Ala Ala Ala Leu 
305                 310                 315                 320 


Ser Ala Thr Ser Ala Gly Arg Tyr Ile Tyr Ile Ser Gly Gly Thr Thr 
                325                 330                 335     


Glu Gln Ile Ser Gly Leu Lys Thr Ala Trp Arg Tyr Asp Met Asp Asp 
            340                 345                 350         


Asn Ser Trp Thr Lys Leu Pro Asp Leu Pro Ile Gly Leu Val Phe His 
        355                 360                 365             


Thr Met Val Thr Cys Gly Gly Thr Val Tyr Ser Val Gly Gly Ser Ile 
    370                 375                 380                 


Ala Pro Arg Arg Tyr Val Ser Asn Ile Tyr Arg Tyr Asp Glu Arg Lys 
385                 390                 395                 400 


Glu Val Trp Cys Leu Ala Gly Lys Met Ser Ile Pro Met Asp Gly Thr 
                405                 410                 415     


Ala Val Ile Thr Lys Gly Asp Arg His Leu Tyr Ile Val Thr Gly Arg 
            420                 425                 430         


Cys Leu Val Lys Gly Tyr Ile Ser Arg Val Gly Val Val Asp Cys Phe 
        435                 440                 445             


Asp Thr Ser Thr Gly Asp Val Val Gln Cys Ile Thr Phe Pro Ile Glu 
    450                 455                 460                 


Phe Asn His Arg Pro Leu Leu Ser Phe Gln Gln Asp Asn Ile Leu Cys 
465                 470                 475                 480 


Val His Ser His Arg Gln Ser Val Glu Ile Asn Leu Gln Lys Val Lys 
                485                 490                 495     


Ala Ser Lys Thr Thr Thr Ser Val Pro Val Leu Pro Asn Ser Cys Pro 
            500                 505                 510         


Leu Asp Val Ser His Ala Ile Cys Ser Ile Gly Asp Ser Lys Val Phe 
        515                 520                 525             


Val Cys Gly Gly Val Thr Thr Ala Ser Asp Val Gln Thr Lys Asp Tyr 
    530                 535                 540                 


Thr Ile Asn Pro Asn Ala Phe Leu Leu Asp Gln Lys Thr Gly Lys Trp 
545                 550                 555                 560 


Lys Thr Leu Ala Pro Pro Pro Glu Ala Leu Asp Cys Pro Ala Cys Cys 
                565                 570                 575     


Leu Ala Lys Leu Pro Cys Lys Ile Leu Gln Arg Ile 
            580                 585             


<210> 5623
<211> 735
<212> PRT
<213> Homo sapiens

<400> 5623
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Thr Ile 
            260                 265                 270         


Arg Lys Ala Gln Asn Leu Leu Lys Gln Tyr Ser Gln His Gly Leu Asp 
        275                 280                 285             


Gly Lys Lys Gly Gly Ser Asn Leu Ile Pro Leu Glu Gly Leu Leu Pro 
    290                 295                 300                 


Cys Thr Pro Arg Gly Gly Leu Pro Gly Pro Trp Ile Asn Ala Ala Cys 
305                 310                 315                 320 


Val Cys Ala Ala Asp Ile Ser Pro Gly His Glu His Asp Phe Arg Val 
                325                 330                 335     


Lys His Leu Ser Glu Ala Leu Asn Asp Lys His Gly Pro Leu Ala Gly 
            340                 345                 350         


Arg Asp Asp Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Val 
        355                 360                 365             


Ser Ala Phe Val Lys Leu Ala Gln Ser Glu Tyr Gln Leu Leu Ala Asp 
    370                 375                 380                 


Ile Ile Pro Glu His His Gln Lys Lys Thr Phe Asp Ser Leu Ile Gln 
385                 390                 395                 400 


Asp Ala Leu Asp Gly Leu Met Leu Glu Gly Glu Asn Ile Val Ser Ala 
                405                 410                 415     


Ala Arg Lys Ala Ile Val Arg His Asp Phe Ser Thr Val Leu Thr Val 
            420                 425                 430         


Phe Pro Ile Leu Arg His Leu Lys Gln Thr Lys Pro Glu Phe Asp Gln 
        435                 440                 445             


Val Leu Gln Gly Thr Ala Ala Ser Thr Lys Asn Lys Leu Pro Gly Leu 
    450                 455                 460                 


Ile Thr Ser Met Glu Thr Ile Gly Ala Lys Ala Leu Glu Asp Phe Ala 
465                 470                 475                 480 


Asp Asn Ile Lys Asn Asp Pro Asp Lys Glu Tyr Asn Met Pro Lys Asp 
                485                 490                 495     


Gly Thr Val His Glu Leu Thr Ser Asn Ala Ile Leu Phe Leu Gln Gln 
            500                 505                 510         


Leu Leu Asp Phe Gln Glu Thr Ala Gly Ala Met Leu Ala Ser Gln Glu 
        515                 520                 525             


Thr Ser Ser Ser Ala Thr Ser Tyr Ser Ser Glu Phe Ser Lys Arg Leu 
    530                 535                 540                 


Leu Ser Thr Tyr Ile Cys Lys Val Leu Gly Asn Leu Gln Leu Asn Leu 
545                 550                 555                 560 


Leu Ser Lys Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser Ala Ile Phe 
                565                 570                 575     


Leu His Asn Asn Tyr Asn Tyr Ile Leu Lys Ser Leu Glu Lys Ser Glu 
            580                 585                 590         


Leu Ile Gln Leu Val Ala Val Thr Gln Lys Thr Ala Glu Arg Ser Tyr 
        595                 600                 605             


Arg Glu His Ile Glu Gln Gln Ile Gln Thr Tyr Gln Arg Ser Trp Leu 
    610                 615                 620                 


Lys Val Thr Asp Tyr Ile Ala Glu Lys Asn Leu Pro Val Phe Gln Pro 
625                 630                 635                 640 


Gly Val Lys Leu Arg Asp Lys Glu Arg Gln Ile Ile Lys Glu Arg Phe 
                645                 650                 655     


Lys Gly Phe Asn Asp Gly Leu Glu Glu Leu Cys Lys Ile Gln Lys Ala 
            660                 665                 670         


Trp Ala Ile Pro Asp Thr Glu Gln Arg Asp Arg Ile Arg Gln Ala Gln 
        675                 680                 685             


Lys Thr Ile Val Lys Glu Thr Tyr Gly Ala Phe Leu Gln Lys Phe Gly 
    690                 695                 700                 


Ser Val Pro Phe Thr Lys Asn Pro Glu Lys Tyr Ile Lys Tyr Gly Val 
705                 710                 715                 720 


Glu Gln Val Gly Asp Met Ile Asp Arg Leu Phe Asp Thr Ser Ala 
                725                 730                 735 


<210> 5624
<211> 125
<212> PRT
<213> Homo sapiens

<400> 5624
Met Ala Gly Ala Gly Pro Thr Met Leu Leu Arg Glu Glu Asn Gly Cys 
1               5                   10                  15      


Cys Ser Arg Arg Gln Ser Ser Ser Ser Ala Gly Asp Ser Asp Gly Glu 
            20                  25                  30          


Arg Glu Asp Ser Ala Ala Glu Arg Ala Arg Gln Gln Leu Glu Ala Leu 
        35                  40                  45              


Leu Asn Lys Thr Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val 
    50                  55                  60                  


Gly Cys Phe Leu Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser 
65                  70                  75                  80  


Ala Gln Glu Phe Leu Lys Pro Ser Asp Ser Phe Ser Ala Gly Glu Pro 
                85                  90                  95      


Arg Val Leu Gly Leu Ala Met Val Pro Gly His His Ile Val Ser Ile 
            100                 105                 110         


Glu Val Gln Arg Glu Ser Leu Thr Gly Pro Pro Tyr Leu 
        115                 120                 125 


<210> 5625
<211> 158
<212> PRT
<213> Homo sapiens

<400> 5625
Met Leu Leu Leu Asp Cys Asn Pro Glu Val Asp Gly Leu Lys His Leu 
1               5                   10                  15      


Leu Glu Thr Gly Ala Ser Val Asn Ala Pro Pro Asp Pro Cys Lys Gln 
            20                  25                  30          


Ser Pro Val His Leu Ala Ala Gly Ser Gly Leu Ala Cys Phe Leu Leu 
        35                  40                  45              


Trp Gln Leu Gln Thr Gly Ala Asp Leu Asn Gln Gln Asp Val Leu Gly 
    50                  55                  60                  


Glu Ala Pro Leu His Lys Ala Ala Lys Val Gly Ser Leu Glu Cys Leu 
65                  70                  75                  80  


Ser Leu Leu Val Ala Ser Asp Ala Gln Ile Asp Leu Cys Asn Lys Asn 
                85                  90                  95      


Gly Gln Thr Ala Glu Asp Leu Ala Trp Ser Cys Gly Phe Pro Asp Cys 
            100                 105                 110         


Ala Lys Phe Leu Thr Thr Ile Lys Cys Met Gln Thr Ile Lys Ala Ser 
        115                 120                 125             


Glu His Pro Asp Arg Asn Asp Cys Val Ala Val Leu Arg Gln Lys Arg 
    130                 135                 140                 


Ser Leu Gly Ser Val Glu Asn Thr Ser Gly Lys Arg Lys Cys 
145                 150                 155             


<210> 5626
<211> 2903
<212> PRT
<213> Homo sapiens

<400> 5626
Met Arg Gly Arg Arg Gly Arg Pro Pro Lys Gln Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Arg Cys Ala Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Thr 
            20                  25                  30          


Ser Gly Pro Ile Gly Gly Leu Arg Ser Arg His Arg Gly Ser Ser Arg 
        35                  40                  45              


Gly Arg Trp Ala Ala Ala Gln Ala Glu Val Ala Pro Lys Thr Arg Leu 
    50                  55                  60                  


Ser Ser Pro Arg Gly Gly Ser Ser Ser Arg Arg Lys Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Ser Thr Ser Ala Pro Gly Arg Gly Gly Arg Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Thr Gly Gly Gly Gly Gly Gly Gly His Leu Ala 
            100                 105                 110         


Arg Thr Thr Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp Asp 
        115                 120                 125             


His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Thr Gln Asp Ser Glu Asp 
145                 150                 155                 160 


Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr Pro 
                165                 170                 175     


Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Thr Glu Ser 
            180                 185                 190         


Ser Phe Arg Ser His Ser Thr Tyr Ser Ser Thr Pro Gly Arg Arg Lys 
        195                 200                 205             


Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp Ile 
    210                 215                 220                 


Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro Asn 
225                 230                 235                 240 


Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn Phe 
                245                 250                 255     


Gly Thr Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys Ala 
            260                 265                 270         


Ala Leu Val Ser Gln Glu Gln Cys Thr Leu Met Ala Glu Met His Val 
        275                 280                 285             


Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Thr Ser Asn Thr Thr 
    290                 295                 300                 


Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Thr Leu Tyr Phe 
305                 310                 315                 320 


Ile Asp Gly Met Thr Trp Pro Glu Val Leu Arg Val Tyr Cys Glu Ser 
                325                 330                 335     


Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp Tyr 
            340                 345                 350         


Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu Val 
        355                 360                 365             


Asp Gln Phe Leu Thr Thr Asn Ile Ala Arg Glu Glu Leu Met Ser Glu 
    370                 375                 380                 


Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Cys Cys Glu Thr Cys Ser Ala Val Tyr His Leu Glu Cys 
                405                 410                 415     


Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys Glu 
            420                 425                 430         


Val Cys Val Ala His Lys Val Pro Gly Val Thr Asp Cys Val Ala Glu 
        435                 440                 445             


Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr Asp 
    450                 455                 460                 


Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile Glu 
465                 470                 475                 480 


Glu Asp Thr Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser Thr 
                485                 490                 495     


Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr Trp 
            500                 505                 510         


Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile His 
        515                 520                 525             


Arg His Met Asp Ile Thr Glu Asp Leu Thr Asn Lys Ala Arg Gly Ser 
    530                 535                 540                 


Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu Thr 
                565                 570                 575     


Glu Lys Asp Lys Asn Glu Thr Glu Asn Asp Ser Lys Asp Ala Glu Lys 
            580                 585                 590         


Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp Asp 
        595                 600                 605             


Lys Thr Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Glu Pro Thr 
    610                 615                 620                 


Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala Asn Leu Gly Asp Asn 
625                 630                 635                 640 


Thr Thr Asn Ala Thr Ser Glu Glu Thr Ser Pro Ser Glu Gly Arg Ser 
                645                 650                 655     


Pro Val Gly Cys Leu Ser Glu Thr Pro Asp Ser Ser Asn Met Ala Glu 
            660                 665                 670         


Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val Pro Glu Glu Pro Asn 
        675                 680                 685             


Lys Thr Cys Glu Ser Ser Asn Thr Ser Ala Thr Thr Thr Ser Ile Gln 
    690                 695                 700                 


Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser Glu Leu Asn Ser Ser Gln 
705                 710                 715                 720 


Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro Glu Asn Gly Glu Arg Glu 
                725                 730                 735     


Ser His Thr Pro Val Ser Ile Gln Glu Glu Ile Val Gly Asp Phe Lys 
            740                 745                 750         


Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala Gly Lys 
        755                 760                 765             


Gly Ala Ser Gly Ser Thr Arg Ile Ile Thr Arg Leu Arg Asn Pro Asp 
    770                 775                 780                 


Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala Ala His 
785                 790                 795                 800 


Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val Val Asn 
                805                 810                 815     


Ser Gln Gly Glu Ile Ser Arg Leu Ser Thr Lys Lys Glu Val Ile Met 
            820                 825                 830         


Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly Lys Tyr 
        835                 840                 845             


Arg Val Tyr His Asn Gln Tyr Ser Thr Asn Ser Phe Ala Leu Asn Lys 
    850                 855                 860                 


His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala His Lys 
865                 870                 875                 880 


Phe Cys Leu Thr Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser Val His 
                885                 890                 895     


Gly Ser Lys Val Leu Thr Ile Ser Thr Leu Arg Leu Thr Ile Thr Gln 
            900                 905                 910         


Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His Pro Asn Trp Ala Ser 
        915                 920                 925             


His Arg Ala Asn Trp Ile Lys Ala Val Gln Met Cys Ser Lys Pro Arg 
    930                 935                 940                 


Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys Ala Val Lys Pro Val 
945                 950                 955                 960 


Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly His Thr Arg Leu His 
                965                 970                 975     


Arg Met Thr Ser Ile Glu Arg Glu Glu Lys Glu Lys Val Lys Lys Lys 
            980                 985                 990         


Glu Lys Lys Gln Glu Glu Glu Glu  Thr Met Gln Gln Ala  Thr Trp Val 
        995                 1000                 1005             


Lys Tyr  Thr Phe Pro Val Lys  His Gln Val Trp Lys  Gln Lys Gly 
    1010                 1015                 1020             


Glu Glu  Tyr Arg Val Thr Gly  Tyr Gly Gly Trp Ser  Trp Ile Ser 
    1025                 1030                 1035             


Lys Thr  His Val Tyr Arg Phe  Val Pro Lys Leu Pro  Gly Asn Thr 
    1040                 1045                 1050             


Asn Val  Asn Tyr Arg Lys Ser  Leu Glu Gly Thr Lys  Asn Asn Met 
    1055                 1060                 1065             


Asp Glu  Asn Met Asp Glu Ser  Asp Lys Arg Lys Cys  Ser Arg Ser 
    1070                 1075                 1080             


Pro Lys  Lys Ile Lys Ile Glu  Pro Asp Ser Glu Lys  Asp Glu Val 
    1085                 1090                 1095             


Lys Gly  Ser Asp Ala Ala Lys  Gly Ala Asp Gln Asn  Glu Met Asp 
    1100                 1105                 1110             


Ile Ser  Lys Ile Thr Glu Lys  Lys Asp Gln Asp Val  Lys Glu Leu 
    1115                 1120                 1125             


Leu Asp  Ser Asp Ser Asp Lys  Pro Cys Lys Glu Glu  Pro Met Glu 
    1130                 1135                 1140             


Val Asp  Asp Asp Met Lys Thr  Glu Ser His Val Asn  Cys Gln Glu 
    1145                 1150                 1155             


Ser Ser  Gln Val Asp Val Val  Asn Val Ser Glu Gly  Phe His Leu 
    1160                 1165                 1170             


Arg Thr  Ser Tyr Lys Lys Lys  Thr Lys Ser Ser Lys  Leu Asp Gly 
    1175                 1180                 1185             


Leu Leu  Glu Arg Arg Ile Lys  Gln Phe Thr Leu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Arg Leu  Glu Lys Ile Lys Leu  Glu Gly Gly Ile Lys  Gly Ile Gly 
    1205                 1210                 1215             


Lys Thr  Ser Thr Asn Ser Ser  Lys Asn Leu Ser Glu  Ser Pro Val 
    1220                 1225                 1230             


Ile Thr  Lys Ala Lys Glu Gly  Cys Gln Ser Asp Ser  Met Arg Gln 
    1235                 1240                 1245             


Glu Gln  Ser Pro Asn Ala Asn  Asn Asp Gln Pro Glu  Asp Leu Ile 
    1250                 1255                 1260             


Gln Gly  Cys Ser Glu Ser Asp  Ser Ser Val Leu Arg  Met Ser Asp 
    1265                 1270                 1275             


Pro Ser  His Thr Thr Asn Lys  Leu Tyr Pro Lys Asp  Arg Val Leu 
    1280                 1285                 1290             


Asp Asp  Val Ser Ile Arg Ser  Pro Glu Thr Lys Cys  Pro Lys Gln 
    1295                 1300                 1305             


Asn Ser  Ile Glu Asn Asp Ile  Glu Glu Lys Val Ser  Asp Leu Ala 
    1310                 1315                 1320             


Ser Arg  Gly Gln Glu Pro Ser  Lys Ser Lys Thr Lys  Gly Asn Asp 
    1325                 1330                 1335             


Phe Phe  Ile Asp Asp Ser Lys  Leu Ala Ser Ala Asp  Asp Ile Gly 
    1340                 1345                 1350             


Thr Leu  Ile Cys Lys Asn Lys  Lys Pro Leu Ile Gln  Glu Glu Ser 
    1355                 1360                 1365             


Asp Thr  Ile Val Ser Ser Ser  Lys Ser Ala Leu His  Ser Ser Val 
    1370                 1375                 1380             


Pro Lys  Ser Thr Asn Asp Arg  Asp Ala Thr Pro Leu  Ser Arg Ala 
    1385                 1390                 1395             


Met Asp  Phe Glu Gly Lys Leu  Gly Cys Asp Ser Glu  Ser Asn Ser 
    1400                 1405                 1410             


Thr Leu  Glu Asn Ser Ser Asp  Thr Val Ser Ile Gln  Asp Ser Ser 
    1415                 1420                 1425             


Glu Glu  Asp Met Ile Val Gln  Asn Ser Asn Glu Ser  Ile Ser Glu 
    1430                 1435                 1440             


Gln Phe  Arg Thr Arg Glu Gln  Asp Val Glu Val Leu  Glu Pro Leu 
    1445                 1450                 1455             


Lys Cys  Glu Leu Val Ser Gly  Glu Ser Thr Gly Asn  Cys Glu Asp 
    1460                 1465                 1470             


Arg Leu  Pro Val Lys Gly Thr  Glu Ala Asn Gly Lys  Lys Pro Ser 
    1475                 1480                 1485             


Gln Gln  Lys Lys Leu Glu Glu  Arg Pro Val Asn Lys  Cys Ser Asp 
    1490                 1495                 1500             


Gln Ile  Lys Leu Lys Asn Thr  Thr Asp Lys Lys Asn  Asn Glu Asn 
    1505                 1510                 1515             


Arg Glu  Ser Glu Lys Lys Gly  Gln Arg Thr Ser Thr  Phe Gln Ile 
    1520                 1525                 1530             


Asn Gly  Lys Asp Asn Lys Pro  Lys Ile Tyr Leu Lys  Gly Glu Cys 
    1535                 1540                 1545             


Leu Lys  Glu Ile Ser Glu Ser  Arg Val Val Ser Gly  Asn Val Glu 
    1550                 1555                 1560             


Pro Lys  Val Asn Asn Ile Asn  Lys Ile Ile Pro Glu  Asn Asp Ile 
    1565                 1570                 1575             


Lys Ser  Leu Thr Val Lys Glu  Ser Ala Ile Arg Pro  Phe Ile Asn 
    1580                 1585                 1590             


Gly Asp  Val Ile Met Glu Asp  Phe Asn Glu Arg Asn  Ser Ser Glu 
    1595                 1600                 1605             


Thr Lys  Ser His Leu Leu Ser  Ser Ser Asp Ala Glu  Gly Asn Tyr 
    1610                 1615                 1620             


Arg Asp  Ser Leu Glu Thr Leu  Pro Ser Thr Lys Glu  Ser Asp Ser 
    1625                 1630                 1635             


Thr Gln  Thr Thr Thr Pro Ser  Ala Ser Cys Pro Glu  Ser Asn Ser 
    1640                 1645                 1650             


Val Asn  Gln Val Glu Asp Met  Glu Ile Glu Thr Ser  Glu Val Lys 
    1655                 1660                 1665             


Lys Val  Thr Ser Ser Pro Ile  Thr Ser Glu Glu Glu  Ser Asn Leu 
    1670                 1675                 1680             


Ser Asn  Asp Phe Ile Asp Glu  Asn Gly Leu Pro Ile  Asn Lys Asn 
    1685                 1690                 1695             


Glu Asn  Val Asn Gly Glu Ser  Lys Arg Lys Thr Val  Ile Thr Glu 
    1700                 1705                 1710             


Val Thr  Thr Met Thr Ser Thr  Val Ala Thr Glu Ser  Lys Thr Val 
    1715                 1720                 1725             


Ile Lys  Val Glu Lys Gly Asp  Lys Gln Thr Val Val  Ser Ser Thr 
    1730                 1735                 1740             


Glu Asn  Cys Ala Lys Ser Thr  Val Thr Thr Thr Thr  Thr Thr Val 
    1745                 1750                 1755             


Thr Lys  Leu Ser Thr Pro Ser  Thr Gly Gly Ser Val  Asp Ile Ile 
    1760                 1765                 1770             


Ser Val  Lys Glu Gln Ser Lys  Thr Val Val Thr Thr  Thr Val Thr 
    1775                 1780                 1785             


Asp Ser  Leu Thr Thr Thr Gly  Gly Thr Leu Val Thr  Ser Met Thr 
    1790                 1795                 1800             


Val Ser  Lys Glu Tyr Ser Thr  Arg Asp Lys Val Lys  Leu Met Lys 
    1805                 1810                 1815             


Phe Ser  Arg Pro Lys Lys Thr  Arg Ser Gly Thr Ala  Leu Pro Ser 
    1820                 1825                 1830             


Tyr Arg  Lys Phe Val Thr Lys  Ser Ser Lys Lys Ser  Ile Phe Val 
    1835                 1840                 1845             


Leu Pro  Asn Asp Asp Leu Lys  Lys Leu Ala Arg Lys  Gly Gly Ile 
    1850                 1855                 1860             


Arg Glu  Val Pro Tyr Phe Asn  Tyr Asn Ala Lys Pro  Ala Leu Asp 
    1865                 1870                 1875             


Ile Trp  Pro Tyr Pro Ser Pro  Arg Pro Thr Phe Gly  Ile Thr Trp 
    1880                 1885                 1890             


Arg Tyr  Arg Leu Gln Thr Val  Lys Ser Leu Ala Gly  Val Ser Leu 
    1895                 1900                 1905             


Met Leu  Arg Leu Leu Trp Ala  Ser Leu Arg Trp Asp  Asp Met Ala 
    1910                 1915                 1920             


Ala Lys  Ala Pro Pro Gly Gly  Gly Thr Thr Arg Thr  Glu Thr Ser 
    1925                 1930                 1935             


Glu Thr  Glu Ile Thr Thr Thr  Glu Ile Ile Lys Arg  Arg Asp Val 
    1940                 1945                 1950             


Gly Pro  Tyr Gly Ile Arg Ser  Glu Tyr Cys Ile Arg  Lys Ile Ile 
    1955                 1960                 1965             


Cys Pro  Ile Gly Val Pro Glu  Thr Pro Lys Glu Thr  Pro Thr Pro 
    1970                 1975                 1980             


Gln Arg  Lys Gly Leu Arg Ser  Ser Ala Leu Arg Pro  Lys Arg Pro 
    1985                 1990                 1995             


Glu Thr  Pro Lys Gln Thr Gly  Pro Val Ile Ile Glu  Thr Trp Val 
    2000                 2005                 2010             


Ala Glu  Glu Glu Leu Glu Leu  Trp Glu Ile Arg Ala  Phe Ala Glu 
    2015                 2020                 2025             


Arg Val  Glu Lys Glu Lys Ala  Gln Ala Val Glu Gln  Gln Ala Lys 
    2030                 2035                 2040             


Lys Arg  Leu Glu Gln Gln Lys  Pro Thr Val Ile Ala  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Pro Thr Ser Ser Thr  Thr Ser Thr Ile Ser  Pro Ala Gln 
    2060                 2065                 2070             


Lys Val  Met Val Ala Pro Ile  Ser Gly Ser Val Thr  Thr Gly Thr 
    2075                 2080                 2085             


Lys Met  Val Leu Thr Thr Lys  Val Gly Ser Pro Ala  Thr Val Thr 
    2090                 2095                 2100             


Phe Gln  Gln Asn Lys Asn Phe  His Gln Thr Phe Ala  Thr Trp Val 
    2105                 2110                 2115             


Lys Gln  Gly Gln Ser Asn Ser  Gly Val Val Gln Val  Gln Gln Lys 
    2120                 2125                 2130             


Val Leu  Gly Ile Ile Pro Ser  Ser Thr Gly Thr Ser  Gln Gln Thr 
    2135                 2140                 2145             


Phe Thr  Ser Phe Gln Pro Arg  Thr Ala Thr Val Thr  Ile Arg Pro 
    2150                 2155                 2160             


Asn Thr  Ser Gly Ser Gly Gly  Thr Thr Ser Asn Ser  Gln Val Ile 
    2165                 2170                 2175             


Thr Gly  Pro Gln Ile Arg Pro  Gly Met Thr Val Ile  Arg Thr Pro 
    2180                 2185                 2190             


Leu Gln  Gln Ser Thr Leu Gly  Lys Ala Ile Ile Arg  Thr Pro Val 
    2195                 2200                 2205             


Met Val  Gln Pro Gly Ala Pro  Gln Gln Val Met Thr  Gln Ile Ile 
    2210                 2215                 2220             


Arg Gly  Gln Pro Val Ser Thr  Ala Val Ser Ala Pro  Asn Thr Val 
    2225                 2230                 2235             


Ser Ser  Thr Pro Gly Gln Lys  Ser Leu Thr Ser Ala  Thr Ser Thr 
    2240                 2245                 2250             


Ser Asn  Ile Gln Ser Ser Ala  Ser Gln Pro Pro Arg  Pro Gln Gln 
    2255                 2260                 2265             


Gly Gln  Val Lys Leu Thr Met  Ala Gln Leu Thr Gln  Leu Thr Gln 
    2270                 2275                 2280             


Gly His  Gly Gly Asn Gln Gly  Leu Thr Val Val Ile  Gln Gly Gln 
    2285                 2290                 2295             


Gly Gln  Thr Thr Gly Gln Leu  Gln Leu Ile Pro Gln  Gly Val Thr 
    2300                 2305                 2310             


Val Leu  Pro Gly Pro Gly Gln  Gln Leu Met Gln Ala  Ala Met Pro 
    2315                 2320                 2325             


Asn Gly  Thr Val Gln Arg Phe  Leu Phe Thr Pro Leu  Ala Thr Thr 
    2330                 2335                 2340             


Ala Thr  Thr Ala Ser Thr Thr  Thr Thr Thr Val Ser  Thr Thr Ala 
    2345                 2350                 2355             


Ala Gly  Thr Gly Glu Gln Arg  Gln Ser Lys Leu Ser  Pro Gln Met 
    2360                 2365                 2370             


Gln Val  His Gln Asp Lys Thr  Leu Pro Pro Ala Gln  Ser Ser Ser 
    2375                 2380                 2385             


Val Gly  Pro Ala Glu Ala Gln  Pro Gln Thr Ala Gln  Pro Ser Ala 
    2390                 2395                 2400             


Gln Pro  Gln Pro Gln Thr Gln  Pro Gln Ser Pro Ala  Gln Pro Glu 
    2405                 2410                 2415             


Val Gln  Thr Gln Pro Glu Val  Gln Thr Gln Thr Thr  Val Ser Ser 
    2420                 2425                 2430             


His Val  Pro Ser Glu Ala Gln  Pro Thr His Ala Gln  Ser Ser Lys 
    2435                 2440                 2445             


Pro Gln  Val Ala Ala Gln Ser  Gln Pro Gln Ser Asn  Val Gln Gly 
    2450                 2455                 2460             


Gln Ser  Pro Val Arg Val Gln  Ser Pro Ser Gln Thr  Arg Ile Arg 
    2465                 2470                 2475             


Pro Ser  Thr Pro Ser Gln Leu  Ser Pro Gly Gln Gln  Ser Gln Val 
    2480                 2485                 2490             


Gln Thr  Thr Thr Ser Gln Pro  Ile Pro Ile Gln Pro  His Thr Ser 
    2495                 2500                 2505             


Leu Gln  Ile Pro Ser Gln Gly  Gln Pro Gln Ser Gln  Pro Gln Val 
    2510                 2515                 2520             


Val Met  Lys His Asn Ala Val  Ile Glu His Leu Lys  Gln Lys Lys 
    2525                 2530                 2535             


Ser Met  Thr Pro Ala Glu Arg  Glu Glu Asn Gln Arg  Met Ile Val 
    2540                 2545                 2550             


Cys Asn  Gln Val Met Lys Tyr  Ile Leu Asp Lys Ile  Asp Lys Glu 
    2555                 2560                 2565             


Glu Lys  Gln Ala Ala Lys Lys  Arg Lys Arg Glu Glu  Ser Val Glu 
    2570                 2575                 2580             


Gln Lys  Arg Ser Lys Gln Asn  Ala Thr Lys Leu Ser  Ala Leu Leu 
    2585                 2590                 2595             


Phe Lys  His Lys Glu Gln Leu  Arg Ala Glu Ile Leu  Lys Lys Arg 
    2600                 2605                 2610             


Ala Leu  Leu Asp Lys Asp Leu  Gln Ile Glu Val Gln  Glu Glu Leu 
    2615                 2620                 2625             


Lys Arg  Asp Leu Lys Ile Lys  Lys Glu Lys Asp Leu  Met Gln Leu 
    2630                 2635                 2640             


Ala Gln  Ala Thr Ala Val Ala  Ala Pro Cys Pro Pro  Val Thr Pro 
    2645                 2650                 2655             


Ala Pro  Pro Ala Pro Pro Ala  Pro Pro Pro Ser Pro  Pro Pro Pro 
    2660                 2665                 2670             


Pro Ala  Val Gln His Thr Gly  Leu Leu Ser Thr Pro  Thr Leu Pro 
    2675                 2680                 2685             


Ala Ala  Ser Gln Lys Arg Lys  Arg Glu Glu Glu Lys  Asp Ser Ser 
    2690                 2695                 2700             


Ser Lys  Ser Lys Lys Lys Lys  Met Ile Ser Thr Thr  Ser Lys Glu 
    2705                 2710                 2715             


Thr Lys  Lys Asp Thr Lys Leu  Tyr Cys Ile Cys Lys  Thr Pro Tyr 
    2720                 2725                 2730             


Asp Glu  Ser Lys Phe Tyr Ile  Gly Cys Asp Arg Cys  Gln Asn Trp 
    2735                 2740                 2745             


Tyr His  Gly Arg Cys Val Gly  Ile Leu Gln Ser Glu  Ala Glu Leu 
    2750                 2755                 2760             


Ile Asp  Glu Tyr Val Cys Pro  Gln Cys Gln Ser Thr  Glu Asp Ala 
    2765                 2770                 2775             


Met Thr  Val Leu Thr Pro Leu  Thr Glu Lys Asp Tyr  Glu Gly Leu 
    2780                 2785                 2790             


Lys Arg  Val Leu Arg Ser Leu  Gln Ala His Lys Met  Ala Trp Pro 
    2795                 2800                 2805             


Phe Leu  Glu Pro Val Asp Pro  Asn Asp Ala Pro Asp  Tyr Tyr Gly 
    2810                 2815                 2820             


Val Ile  Lys Glu Pro Met Asp  Leu Ala Thr Met Glu  Glu Arg Val 
    2825                 2830                 2835             


Gln Arg  Arg Tyr Tyr Glu Lys  Leu Thr Glu Phe Val  Ala Asp Met 
    2840                 2845                 2850             


Thr Lys  Ile Phe Asp Asn Cys  Arg Tyr Tyr Asn Pro  Ser Asp Ser 
    2855                 2860                 2865             


Pro Phe  Tyr Gln Cys Ala Glu  Val Leu Glu Ser Phe  Phe Val Gln 
    2870                 2875                 2880             


Lys Leu  Lys Gly Phe Lys Ala  Ser Arg Ser His Asn  Asn Lys Leu 
    2885                 2890                 2895             


Gln Ser  Thr Ala Ser 
    2900             


<210> 5627
<211> 875
<212> PRT
<213> Homo sapiens

<400> 5627
Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Gln 
1               5                   10                  15      


Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser Asn Ser Ala Ala 
            20                  25                  30          


Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr 
        35                  40                  45              


Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu Ala Leu Gln Asn 
    50                  55                  60                  


Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser Phe Val Asn Ser 
65                  70                  75                  80  


Gln Glu Trp Thr Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile 
                85                  90                  95      


Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu 
            100                 105                 110         


Thr Gly Thr Tyr Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys 
        115                 120                 125             


Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp 
    130                 135                 140                 


Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp Val Asp Ala Val 
145                 150                 155                 160 


Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr 
                165                 170                 175     


Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala Ser Glu Val Pro 
            180                 185                 190         


Met Val Leu Val Gly Thr Gln Asp Ala Ile Ser Ala Ala Asn Pro Arg 
        195                 200                 205             


Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Thr Asp Leu Lys Arg 
    210                 215                 220                 


Cys Thr Tyr Tyr Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg 
225                 230                 235                 240 


Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu Arg Lys Lys Gln 
                245                 250                 255     


Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His 
            260                 265                 270         


Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His Ile Asn Gln Ala 
        275                 280                 285             


Thr Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser Ser Ser Val Pro 
    290                 295                 300                 


Ser Thr Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile Glu Thr Ile Ala 
305                 310                 315                 320 


Ala Ser Ser Thr Pro Thr Pro Ile Arg Lys Gln Ser Lys Arg Arg Ser 
                325                 330                 335     


Asn Ile Phe Thr Ser Arg Lys Gly Ala Asp Leu Asp Arg Glu Lys Lys 
            340                 345                 350         


Ala Ala Glu Cys Lys Val Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro 
        355                 360                 365             


Ile Lys Gln Gly Ile Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys 
    370                 375                 380                 


Glu Trp Lys Lys Lys Tyr Val Thr Leu Cys Asp Asn Gly Leu Leu Thr 
385                 390                 395                 400 


Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Ile His Gly Lys Glu 
                405                 410                 415     


Ile Asp Leu Leu Arg Thr Thr Val Lys Val Pro Gly Lys Arg Leu Pro 
            420                 425                 430         


Arg Ala Thr Pro Ala Thr Ala Pro Gly Thr Ser Pro Arg Ala Asn Gly 
        435                 440                 445             


Leu Ser Val Glu Arg Ser Asn Thr Gln Leu Gly Gly Gly Thr Gly Ala 
    450                 455                 460                 


Pro His Ser Ala Ser Ser Ala Ser Leu His Ser Glu Arg Pro Leu Ser 
465                 470                 475                 480 


Ser Ser Ala Trp Ala Gly Pro Arg Pro Glu Gly Leu His Gln Arg Ser 
                485                 490                 495     


Cys Ser Val Ser Ser Ala Asp Gln Trp Ser Glu Ala Thr Thr Ser Leu 
            500                 505                 510         


Pro Pro Gly Met Gln His Pro Ala Ser Gly Pro Ala Glu Val Leu Ser 
        515                 520                 525             


Ser Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ser Asn Arg Lys 
    530                 535                 540                 


Lys His Arg Arg Lys Lys Ser Thr Gly Thr Pro Arg Pro Asp Gly Pro 
545                 550                 555                 560 


Ser Ser Ala Thr Glu Glu Ala Glu Glu Ser Phe Glu Phe Val Val Val 
                565                 570                 575     


Ser Leu Thr Gly Gln Thr Trp His Phe Glu Ala Ser Thr Ala Glu Glu 
            580                 585                 590         


Arg Glu Leu Trp Val Gln Ser Val Gln Ala Gln Ile Leu Ala Ser Leu 
        595                 600                 605             


Gln Gly Cys Arg Ser Ala Lys Asp Lys Thr Arg Leu Gly Asn Gln Asn 
    610                 615                 620                 


Ala Ala Leu Ala Val Gln Ala Val Arg Thr Val Arg Gly Asn Ser Phe 
625                 630                 635                 640 


Cys Ile Asp Cys Asp Ala Pro Asn Pro Asp Trp Ala Ser Leu Asn Leu 
                645                 650                 655     


Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg His Leu Gly 
            660                 665                 670         


Ala His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Pro 
        675                 680                 685             


Glu Leu Leu Ala Val Met Thr Ala Met Gly Asn Ala Leu Ala Asn Ser 
    690                 695                 700                 


Val Trp Glu Gly Ala Leu Gly Gly Tyr Ser Lys Pro Gly Pro Asp Ala 
705                 710                 715                 720 


Cys Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys 
                725                 730                 735     


Leu Phe Leu Ala Pro Leu Pro Ser Ser Asp Val Pro Leu Gly Gln Gln 
            740                 745                 750         


Leu Leu Arg Ala Val Val Glu Asp Asp Leu Arg Leu Leu Val Met Leu 
        755                 760                 765             


Leu Ala His Gly Ser Lys Glu Glu Val Asn Glu Thr Tyr Gly Asp Gly 
    770                 775                 780                 


Asp Gly Arg Thr Ala Leu His Leu Ser Ser Ala Met Ala Asn Val Val 
785                 790                 795                 800 


Phe Thr Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Arg Ser Arg Asp 
                805                 810                 815     


Ala Arg Gly Leu Thr Pro Leu Ala Tyr Ala Arg Arg Ala Gly Ser Gln 
            820                 825                 830         


Glu Cys Ala Asp Ile Leu Ile Gln His Gly Cys Pro Gly Glu Gly Cys 
        835                 840                 845             


Gly Leu Ala Pro Thr Pro Asn Arg Glu Pro Ala Asn Gly Thr Asn Pro 
    850                 855                 860                 


Ser Ala Glu Leu His Arg Ser Pro Ser Leu Leu 
865                 870                 875 


<210> 5628
<211> 586
<212> PRT
<213> Homo sapiens

<400> 5628
Met Gly Gly Ala Leu Gly Leu Arg Gln Leu Pro Ile Cys Ala Pro Ala 
1               5                   10                  15      


Cys Arg Pro Ser Ser Gly His Ser Pro Trp Ala Ala Ala Ser Pro Asn 
            20                  25                  30          


Pro Asn Gln Trp Ser Ser Arg Ser Arg Trp Cys Cys Leu Arg Arg Ser 
        35                  40                  45              


Glu Ala Arg Arg Ser Cys Arg Pro Val Gly Arg Ala Ala Pro Gly Pro 
    50                  55                  60                  


Thr Arg Ala Met Ala Arg Pro Ala Thr Ser Thr Arg Arg Ser Ala Cys 
65                  70                  75                  80  


Pro Pro Leu Thr Pro Thr Pro Ala Leu Arg Ile Ala Trp Arg Leu Leu 
                85                  90                  95      


Ser Ala Thr Ser Arg Thr Ser Arg Met Ala Ser Val Leu Ser Arg Gly 
            100                 105                 110         


Arg Val Arg Cys Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly 
        115                 120                 125             


Asp Leu Glu Asp Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val 
    130                 135                 140                 


Lys Ile Glu Lys Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu 
145                 150                 155                 160 


Gln Leu Gln Arg Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser 
                165                 170                 175     


Ala Gly Tyr Ser Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala 
            180                 185                 190         


Ala Gly Leu Val Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp 
        195                 200                 205             


Arg Ile Val Leu Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro 
    210                 215                 220                 


Lys Leu Ser Lys Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg 
225                 230                 235                 240 


Pro Lys Glu Phe Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala 
                245                 250                 255     


Gln Val Val Thr Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp 
            260                 265                 270         


Gly Phe Lys Leu Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser 
        275                 280                 285             


Pro Lys Thr Leu Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr 
    290                 295                 300                 


Ile Arg Thr Pro Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly 
305                 310                 315                 320 


Arg Asn Val Val Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala 
                325                 330                 335     


Ala Tyr Leu Thr Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu 
            340                 345                 350         


Glu Thr Pro Phe Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu 
        355                 360                 365             


Met Lys Met Phe Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu 
    370                 375                 380                 


Val Ser Glu Leu Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu 
385                 390                 395                 400 


Lys Ser Ser Lys Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly 
                405                 410                 415     


Ala Val Pro Ala Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp 
            420                 425                 430         


Ser Arg Gly Phe Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro 
        435                 440                 445             


Gly Val Phe Ala Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg 
    450                 455                 460                 


Asn Asn Arg Lys Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln 
465                 470                 475                 480 


Gly Arg Val Ala Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser 
                485                 490                 495     


Thr Val Pro Tyr Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr 
            500                 505                 510         


Ala Gly Tyr Gly Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu 
        515                 520                 525             


Glu Glu Leu Lys Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile 
    530                 535                 540                 


Ala Val Ala Ser Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu 
545                 550                 555                 560 


Val Leu Ala Ser Gly Arg Ala Ile Arg Lys Arg Glu Val Glu Thr Gly 
                565                 570                 575     


Asp Met Ser Trp Leu Thr Gly Lys Gly Ser 
            580                 585     


<210> 5629
<211> 506
<212> PRT
<213> Homo sapiens

<400> 5629
Met Pro Val Gln Ala Ala Gln Trp Thr Glu Phe Leu Ser Cys Pro Ile 
1               5                   10                  15      


Cys Tyr Asn Glu Phe Asp Glu Asn Val His Lys Pro Ile Ser Leu Gly 
            20                  25                  30          


Cys Ser His Thr Val Cys Lys Thr Cys Leu Asn Lys Leu His Arg Lys 
        35                  40                  45              


Ala Cys Pro Phe Asp Gln Thr Ala Ile Asn Thr Asp Ile Asp Val Leu 
    50                  55                  60                  


Pro Val Asn Phe Ala Leu Leu Gln Leu Val Gly Ala Gln Val Pro Asp 
65                  70                  75                  80  


His Gln Ser Ile Lys Leu Ser Asn Leu Gly Glu Asn Lys His Tyr Glu 
                85                  90                  95      


Val Ala Lys Lys Cys Val Glu Asp Leu Ala Leu Tyr Leu Lys Pro Leu 
            100                 105                 110         


Ser Gly Gly Lys Gly Val Ala Ser Leu Asn Gln Ser Ala Leu Ser Arg 
        115                 120                 125             


Pro Met Gln Arg Lys Leu Val Thr Leu Val Asn Cys Gln Leu Val Glu 
    130                 135                 140                 


Glu Glu Gly Arg Val Arg Ala Met Arg Ala Ala Arg Ser Leu Gly Glu 
145                 150                 155                 160 


Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro Gln Gln Leu 
                165                 170                 175     


Ser Ala Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys Gln Phe Leu 
            180                 185                 190         


Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu Leu Ala Leu 
        195                 200                 205             


Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu Phe Val Val 
    210                 215                 220                 


Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr Ser Ile Gly 
225                 230                 235                 240 


His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys Val Thr Lys 
                245                 250                 255     


Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu Phe Arg Ser 
            260                 265                 270         


Tyr Glu Ala Leu Arg Arg Glu His Asp Ala Gln Ile Val His Ile Ala 
        275                 280                 285             


Met Glu Ala Gly Leu Arg Ile Ser Pro Glu Gln Trp Ser Ser Leu Leu 
    290                 295                 300                 


Tyr Gly Asp Leu Ala His Lys Ser His Met Gln Ser Ile Ile Asp Lys 
305                 310                 315                 320 


Leu Gln Ser Pro Glu Ser Phe Ala Lys Ser Val Gln Glu Leu Thr Ile 
                325                 330                 335     


Val Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg Leu Arg Pro 
            340                 345                 350         


His Leu Glu Leu Leu Ala Asn Ile Asp Pro Asn Pro Asp Ala Val Ser 
        355                 360                 365             


Pro Thr Trp Glu Gln Leu Glu Asn Ala Met Val Ala Val Lys Thr Val 
    370                 375                 380                 


Val His Gly Leu Val Asp Phe Ile Gln Asn Tyr Ser Arg Lys Gly His 
385                 390                 395                 400 


Glu Thr Pro Gln Pro Gln Pro Asn Ser Lys Tyr Lys Thr Ser Met Cys 
                405                 410                 415     


Arg Asp Leu Arg Gln Gln Gly Gly Cys Pro Arg Gly Thr Asn Cys Thr 
            420                 425                 430         


Phe Ala His Ser Gln Glu Glu Leu Glu Lys Cys Asn Pro Arg Gly Leu 
        435                 440                 445             


Tyr Leu His Cys Cys Leu Leu Ser Ser Val Ala Ser Leu Gly Thr Val 
    450                 455                 460                 


His Asn Glu Leu Tyr Lys Gln Gln His Cys Asp Arg Glu Lys Ile Ser 
465                 470                 475                 480 


Val Cys Ala Val Lys Arg Ala Glu Thr Cys Phe Ser Ser Gln Phe Phe 
                485                 490                 495     


Ser Pro Leu Glu Val Pro Arg Glu Glu Asp 
            500                 505     


<210> 5630
<211> 260
<212> PRT
<213> Homo sapiens

<400> 5630
Met Pro Arg Ala Arg Ser Gly Arg Arg Ser Arg Gly Ala Gly Gly Arg 
1               5                   10                  15      


Glu Glu Thr Phe Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn 
            20                  25                  30          


Ala Arg Ile Gly Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Val 
        35                  40                  45              


Cys Pro Leu Cys Asn Arg Pro Leu Ala Gly Ser Glu Gln Glu Met Ser 
    50                  55                  60                  


Arg His Val Glu His Cys Leu Ser Lys Arg Glu Gly Ser Cys Met Ala 
65                  70                  75                  80  


Glu Asp Asp Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg Phe Glu 
                85                  90                  95      


Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr Leu Leu 
            100                 105                 110         


Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly Lys Glu 
        115                 120                 125             


Asn Pro Asp Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp Thr Leu 
    130                 135                 140                 


Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro Cys Thr 
145                 150                 155                 160 


Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg Gly Ala 
                165                 170                 175     


Val Leu Asn Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu Phe Ser 
            180                 185                 190         


Lys Trp Ala Ser Asp Glu Met Pro Ser Thr Ser Asn Gly Glu Ser Ser 
        195                 200                 205             


Lys Gln Glu Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile Glu Lys 
    210                 215                 220                 


Ile Thr Glu Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys Ala Arg 
225                 230                 235                 240 


Val Arg Glu Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr Lys Cys 
                245                 250                 255     


Leu Ile Cys Met 
            260 


<210> 5631
<211> 486
<212> PRT
<213> Homo sapiens

<400> 5631
Met Ala Ala Val Lys Thr Leu Asn Pro Lys Ala Glu Val Ala Arg Ala 
1               5                   10                  15      


Gln Ala Ala Leu Ala Val Asn Ile Ser Ala Ala Arg Gly Leu Gln Asp 
            20                  25                  30          


Val Leu Arg Thr Asn Leu Gly Pro Lys Gly Thr Met Lys Met Leu Val 
        35                  40                  45              


Ser Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu Leu 
    50                  55                  60                  


His Glu Met Gly Leu His Pro Arg Ile Ile Thr Glu Gly Phe Glu Ala 
65                  70                  75                  80  


Ala Lys Glu Lys Ala Leu Gln Phe Leu Glu Glu Val Lys Val Ser Arg 
                85                  90                  95      


Glu Met Asp Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg 
            100                 105                 110         


Thr Lys Val His Ala Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val 
        115                 120                 125             


Asp Ser Ile Leu Ala Ile Lys Lys Gln Asp Glu Pro Ile Asp Leu Phe 
    130                 135                 140                 


Met Ile Glu Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser 
145                 150                 155                 160 


Leu Ile Arg Gly Leu Val Leu Asp His Gly Ala Arg His Pro Asp Met 
                165                 170                 175     


Lys Lys Arg Val Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu 
            180                 185                 190         


Glu Tyr Glu Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala 
        195                 200                 205             


Glu Glu Arg Glu Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp 
    210                 215                 220                 


Arg Val Lys Lys Ile Ile Glu Leu Lys Arg Lys Val Cys Gly Asp Ser 
225                 230                 235                 240 


Asp Lys Gly Phe Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser 
                245                 250                 255     


Leu Asp Ala Leu Ser Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys 
            260                 265                 270         


Arg Arg Asn Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Val Ala Leu 
        275                 280                 285             


Asn Ser Phe Asp Asp Leu Ser Pro Asp Cys Leu Gly His Ala Gly Leu 
    290                 295                 300                 


Val Tyr Glu Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys 
305                 310                 315                 320 


Cys Asn Asn Pro Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn Lys 
                325                 330                 335     


His Thr Leu Thr Gln Ile Lys Asp Ala Val Arg Asp Gly Leu Arg Ala 
            340                 345                 350         


Val Lys Asn Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala 
        355                 360                 365             


Val Glu Val Ala Met Ala Glu Ala Leu Ile Lys His Lys Pro Ser Val 
    370                 375                 380                 


Lys Gly Arg Ala Gln Leu Gly Val Gln Ala Phe Ala Asp Ala Leu Leu 
385                 390                 395                 400 


Ile Ile Pro Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu 
                405                 410                 415     


Thr Leu Val Lys Ile Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val 
            420                 425                 430         


Gly Val Asp Leu Asn Thr Gly Glu Pro Met Val Ala Ala Glu Val Gly 
        435                 440                 445             


Val Trp Asp Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr 
    450                 455                 460                 


Val Ile Ala Thr Asn Ile Leu Leu Val Asp Glu Ile Met Arg Ala Gly 
465                 470                 475                 480 


Met Ser Ser Leu Lys Gly 
                485     


<210> 5632
<211> 468
<212> PRT
<213> Homo sapiens

<400> 5632
Met Ser Phe Arg Leu Ser Gly Gly Ser Arg Arg Ile Cys Ser Arg Thr 
1               5                   10                  15      


Gly Ser Gly Arg Leu Ser Gly Gly Gly Thr Gly Phe Val Ala Gly Asn 
            20                  25                  30          


Val Cys Val Gly Ser Gly Ala Arg Ser Ser Phe Ser Cys Thr Leu Glu 
        35                  40                  45              


Gly Ile Ser Ser Gly Gly Ser Phe Cys Asn Ser Gly Gly Gly Leu Gly 
    50                  55                  60                  


Ser Gly Ala Cys Ala Gly Phe Leu Gly Asn Glu His Ser Leu Leu Ser 
65                  70                  75                  80  


Gly Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser 
                85                  90                  95      


Tyr Leu Asp His Val His Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu 
            100                 105                 110         


Gln Lys Ile Lys Gly Trp Tyr Glu Lys Cys Glu Pro Gly Ser Ser Arg 
        115                 120                 125             


Glu His Asp His Asp Tyr Ser Arg Tyr Phe Ser Val Ile Glu Asp Leu 
    130                 135                 140                 


Lys Arg Gln Ile Ile Ser Ala Thr Ile Cys Asn Ala Ser Ile Val Leu 
145                 150                 155                 160 


Gln Asn Asp Asn Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys Tyr 
                165                 170                 175     


Glu Asn Glu Leu Ala Leu His His Ser Val Glu Ala Asp Thr Ser Gly 
            180                 185                 190         


Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Cys Thr Thr Asp Leu Glu 
        195                 200                 205             


Ile Gln Cys Glu Thr Leu Ser Glu Glu Leu Thr Tyr Leu Lys Lys Ser 
    210                 215                 220                 


His Glu Glu Glu Met Glu Val Leu Gln Tyr Thr Ala Gly Gly Asn Val 
225                 230                 235                 240 


Asn Val Glu Met Asn Ala Thr Pro Gly Val Asp Leu Thr Val Leu Leu 
                245                 250                 255     


Asn Asn Met Arg Ala Glu Tyr Glu Asp Leu Ala Glu Gln Asn Arg Lys 
            260                 265                 270         


Asp Ala Glu Ala Trp Phe Asn Glu Arg Ser Ala Thr Leu Gln Gln Gln 
        275                 280                 285             


Ile Ser Asp His Glu Gly Ala Ala Thr Ala Ala Arg Asn Glu Leu Thr 
    290                 295                 300                 


Glu Leu Lys Arg Asn Leu Gln Thr Leu Glu Ile Glu Leu Gln Ser Leu 
305                 310                 315                 320 


Met Ala Val Lys His Ser Tyr Glu Cys Ser Leu Ala Glu Thr Glu Gly 
                325                 330                 335     


Asn Tyr Cys Asn Gln Leu Gln Gln Ile Gln Asp Gln Ile Gly Val Met 
            340                 345                 350         


Glu Glu Gln Leu Gln Gln Ile Arg Thr Glu Thr Glu Gly Gln Lys Leu 
        355                 360                 365             


Glu Tyr Glu Gln Leu Leu Asp Val Lys Ile Phe Leu Glu Lys Glu Ile 
    370                 375                 380                 


Asp Ile Tyr Cys Asn Leu Leu Asp Gly Glu Glu Arg Lys Ser Lys Ser 
385                 390                 395                 400 


Thr Cys Tyr Lys Ser Lys Gly Tyr Arg Pro Val Asn Ser Gly Asn Gln 
                405                 410                 415     


Ala Lys Asp Ser Thr Glu Glu Thr Ile Val Lys Thr Val Val Glu Glu 
            420                 425                 430         


Leu Asp Gln Ile Gly Asn Leu Leu Ser Leu Arg Val His Ser Val Glu 
        435                 440                 445             


Glu Lys Ser Ser Lys Ile Ser Asn Ile Thr Val Glu Gln Arg Val Pro 
    450                 455                 460                 


Ser Lys Ala Pro 
465             


<210> 5633
<211> 271
<212> PRT
<213> Homo sapiens

<400> 5633
Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Phe Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Glu Tyr 
                85                  90                  95      


Gly Ser Gln Gln Val Ala Asp Leu Thr Leu Asn Leu Asp Asp Tyr Ile 
            100                 105                 110         


Asp Ala Glu His Leu Gly Asp Phe His Arg Thr Tyr Lys Asn Ser Glu 
        115                 120                 125             


Glu Leu Arg Ser Arg Ile Val Ser Gly Ile Ile Thr Pro Ile His Glu 
    130                 135                 140                 


Gln Trp Glu Lys Ala Asn Val Ser Ser Pro His Arg Glu Phe Pro Pro 
145                 150                 155                 160 


Ala Thr Ala Arg Glu Val Asp Pro Leu Arg Ile Pro Pro His His Pro 
                165                 170                 175     


His Thr Ser Arg Gln Pro Pro Trp Cys Asp Pro Leu Gly Pro Phe Val 
            180                 185                 190         


Val Gly Gly Glu Asp Leu Asp Pro Phe Gly Pro Arg Arg Gly Gly Met 
        195                 200                 205             


Ile Val Asp Pro Leu Arg Ser Gly Phe Pro Arg Ala Leu Ile Asp Pro 
    210                 215                 220                 


Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro Gly Ala Val Pro Pro Gly 
225                 230                 235                 240 


Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly Thr Ser Pro Pro Gly Pro 
                245                 250                 255     


Asn Pro Asp His Leu Pro Pro Pro Gly Tyr Asp Asp Met Tyr Leu 
            260                 265                 270     


<210> 5634
<211> 250
<212> PRT
<213> Homo sapiens

<400> 5634
Met Ser Glu Asn Ala Ala Pro Asp Phe Tyr Tyr Val Ala Met Asp Phe 
1               5                   10                  15      


Gly Gly His Gly Leu Ser Ser His Tyr Ser Pro Gly Val Pro Tyr Tyr 
            20                  25                  30          


Leu Gln Thr Phe Val Ser Glu Ile Arg Arg Val Val Ala Gly Gly Val 
        35                  40                  45              


Val Gly Gly Met Phe Phe Cys Thr Phe Pro Glu Met Val Asp Lys Leu 
    50                  55                  60                  


Ile Leu Leu Asp Thr Pro Leu Phe Leu Leu Glu Ser Asp Glu Met Glu 
65                  70                  75                  80  


Asn Leu Leu Thr Tyr Lys Arg Arg Ala Ile Glu His Val Leu Gln Val 
                85                  90                  95      


Glu Ala Ser Gln Glu Pro Ser His Val Phe Ser Leu Lys Gln Leu Leu 
            100                 105                 110         


Gln Arg Leu Leu Lys Ser Asn Ser His Leu Ser Glu Glu Cys Gly Glu 
        115                 120                 125             


Leu Leu Leu Gln Arg Gly Thr Thr Lys Val Ala Thr Gly Leu Val Leu 
    130                 135                 140                 


Asn Arg Asp Gln Arg Leu Ala Trp Ala Glu Asn Ser Ile Asp Phe Ile 
145                 150                 155                 160 


Ser Arg Glu Leu Cys Ala His Ser Ile Arg Lys Leu Gln Ala His Val 
                165                 170                 175     


Leu Leu Ile Lys Ala Val His Gly Tyr Phe Asp Ser Arg Gln Asn Tyr 
            180                 185                 190         


Ser Glu Lys Glu Ser Leu Ser Phe Met Ile Asp Thr Met Lys Ser Thr 
        195                 200                 205             


Leu Lys Glu Gln Phe Gln Phe Val Glu Val Pro Gly Asn His Cys Val 
    210                 215                 220                 


His Met Ser Glu Pro Gln His Val Ala Ser Ile Ile Ser Ser Phe Leu 
225                 230                 235                 240 


Gln Cys Thr His Met Leu Pro Ala Gln Leu 
                245                 250 


<210> 5635
<211> 169
<212> PRT
<213> Homo sapiens

<400> 5635
Met Val Phe Pro Leu Pro Thr Pro Gln Glu Pro Ile Met Ala Thr Pro 
1               5                   10                  15      


Pro Lys Arg Arg Ala Val Glu Ala Thr Gly Glu Lys Val Leu Arg Tyr 
            20                  25                  30          


Glu Thr Phe Ile Ser Asp Val Leu Gln Arg Asp Leu Arg Lys Val Leu 
        35                  40                  45              


Asp His Arg Asp Lys Val Tyr Glu Gln Leu Ala Lys Tyr Leu Gln Leu 
    50                  55                  60                  


Arg Asn Val Ile Glu Arg Leu Gln Glu Ala Lys His Ser Glu Leu Tyr 
65                  70                  75                  80  


Met Gln Val Asp Leu Gly Cys Asn Phe Phe Val Asp Thr Val Val Pro 
                85                  90                  95      


Asp Thr Ser Arg Ile Tyr Val Ala Leu Gly Tyr Gly Phe Phe Leu Glu 
            100                 105                 110         


Leu Thr Leu Ala Glu Ala Leu Lys Phe Ile Asp Arg Lys Ser Ser Leu 
        115                 120                 125             


Leu Thr Glu Leu Ser Asn Ser Leu Thr Lys Asp Ser Met Asn Ile Lys 
    130                 135                 140                 


Ala His Ile His Met Leu Leu Glu Gly Leu Arg Glu Leu Gln Gly Leu 
145                 150                 155                 160 


Gln Asn Phe Pro Glu Lys Pro His His 
                165                 


<210> 5636
<211> 1058
<212> PRT
<213> Homo sapiens

<400> 5636
Met Thr Thr Val Val Val His Val Asp Ser Lys Ala Glu Leu Thr Thr 
1               5                   10                  15      


Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val 
            20                  25                  30          


Pro Ile Leu Thr Arg Met Ser Gln Leu Ile Glu Lys Glu Thr Glu Glu 
        35                  40                  45              


Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg 
    50                  55                  60                  


Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys 
65                  70                  75                  80  


Asn Asp Asp Phe Met Asn Ala Leu Val Asn Ala Tyr Val Met Thr Ser 
                85                  90                  95      


Arg Glu Pro Pro Leu Asn Thr Ala Ala Cys Arg Leu Leu Leu Asp Ile 
            100                 105                 110         


Met Pro Gly Leu Glu Thr Ala Val Val Phe Gln Glu Lys Glu Gly Ile 
        115                 120                 125             


Val Glu Asn Leu Phe Lys Trp Ala Arg Glu Ala Asp Gln Pro Leu Arg 
    130                 135                 140                 


Thr Tyr Ser Thr Gly Leu Leu Gly Gly Ala Met Glu Asn Gln Asp Ile 
145                 150                 155                 160 


Ala Ala Asn Tyr Arg Asp Glu Asn Ser Gln Leu Val Ala Ile Val Leu 
                165                 170                 175     


Arg Arg Leu Arg Glu Leu Gln Leu Gln Glu Val Ala Leu Arg Gln Glu 
            180                 185                 190         


Asn Lys Arg Pro Ser Pro Arg Lys Leu Ser Ser Glu Pro Leu Leu Pro 
        195                 200                 205             


Leu Asp Glu Glu Ala Val Asp Met Asp Tyr Gly Asp Met Ala Val Asp 
    210                 215                 220                 


Asp Ala Glu Ile Gln Lys Ser Ala Leu Gln Ile Ile Ile Asn Cys Val 
225                 230                 235                 240 


Cys Gly Pro Asp Asn Arg Ile Ser Ser Ile Gly Lys Phe Ile Ser Gly 
                245                 250                 255     


Thr Pro Arg Arg Lys Leu Pro Gln Asn Pro Lys Ser Ser Glu His Thr 
            260                 265                 270         


Leu Ala Lys Met Trp Asn Val Val Gln Ser Asn Asn Gly Ile Lys Val 
        275                 280                 285             


Leu Leu Ser Leu Leu Ser Ile Lys Met Pro Ile Thr Asp Ala Asp Gln 
    290                 295                 300                 


Ile Arg Ala Leu Ala Cys Lys Ala Leu Val Gly Leu Ser Arg Ser Ser 
305                 310                 315                 320 


Thr Val Arg Gln Ile Ile Ser Lys Leu Pro Leu Phe Ser Ser Cys Gln 
                325                 330                 335     


Ile Gln Gln Leu Met Lys Glu Pro Val Leu Gln Asp Lys Arg Ser Asp 
            340                 345                 350         


His Val Lys Phe Cys Lys Tyr Ala Ala Glu Leu Ile Glu Arg Val Ser 
        355                 360                 365             


Gly Lys Pro Leu Leu Ile Gly Thr Asp Val Ser Leu Ala Arg Leu Gln 
    370                 375                 380                 


Lys Ala Asp Val Val Ala Gln Ser Arg Ile Ser Phe Pro Glu Lys Glu 
385                 390                 395                 400 


Leu Leu Leu Leu Ile Arg Asn His Leu Ile Ser Lys Gly Leu Gly Glu 
                405                 410                 415     


Thr Ala Thr Val Leu Thr Lys Glu Ala Asp Leu Pro Met Thr Ala Ala 
            420                 425                 430         


Ser His Ser Ser Ala Phe Thr Pro Val Thr Ala Ala Ala Ser Pro Val 
        435                 440                 445             


Ser Leu Pro Arg Thr Pro Arg Ile Ala Asn Gly Ile Ala Thr Arg Leu 
    450                 455                 460                 


Gly Ser His Ala Ala Val Gly Ala Ser Ala Pro Ser Ala Pro Thr Ala 
465                 470                 475                 480 


His Pro Gln Pro Arg Pro Pro Gln Gly Pro Leu Ala Leu Pro Gly Pro 
                485                 490                 495     


Ser Tyr Ala Gly Asn Ser Pro Leu Ile Gly Arg Ile Ser Phe Ile Arg 
            500                 505                 510         


Glu Arg Pro Ser Pro Cys Asn Gly Arg Lys Ile Arg Val Leu Arg Gln 
        515                 520                 525             


Lys Ser Asp His Gly Ala Tyr Ser Gln Ser Pro Ala Ile Lys Lys Gln 
    530                 535                 540                 


Leu Asp Arg His Leu Pro Ser Pro Pro Thr Leu Asp Ser Ile Ile Thr 
545                 550                 555                 560 


Glu Tyr Leu Arg Glu Gln His Ala Arg Cys Lys Asn Pro Val Ala Thr 
                565                 570                 575     


Cys Pro Pro Phe Ser Leu Phe Thr Pro His Gln Cys Pro Glu Pro Lys 
            580                 585                 590         


Gln Arg Arg Gln Ala Pro Ile Asn Phe Thr Ser Arg Leu Asn Arg Arg 
        595                 600                 605             


Ala Ser Phe Pro Lys Tyr Gly Gly Val Asp Gly Gly Cys Phe Asp Arg 
    610                 615                 620                 


His Leu Ile Phe Ser Arg Phe Arg Pro Ile Ser Val Phe Arg Glu Ala 
625                 630                 635                 640 


Asn Glu Asp Glu Ser Gly Phe Thr Cys Cys Ala Phe Ser Ala Arg Glu 
                645                 650                 655     


Arg Phe Leu Met Leu Gly Thr Cys Thr Gly Gln Leu Lys Leu Tyr Asn 
            660                 665                 670         


Val Phe Ser Gly Gln Glu Glu Ala Ser Tyr Asn Cys His Asn Ser Ala 
        675                 680                 685             


Ile Thr His Leu Glu Pro Ser Arg Asp Gly Ser Leu Leu Leu Thr Ser 
    690                 695                 700                 


Ala Thr Trp Ser Gln Pro Leu Ser Ala Leu Trp Gly Met Lys Ser Val 
705                 710                 715                 720 


Phe Asp Met Lys His Ser Phe Thr Glu Asp His Tyr Val Glu Phe Ser 
                725                 730                 735     


Lys His Ser Gln Asp Arg Val Ile Gly Thr Lys Gly Asp Ile Ala His 
            740                 745                 750         


Ile Tyr Asp Ile Gln Thr Gly Asn Lys Leu Leu Thr Leu Phe Asn Pro 
        755                 760                 765             


Asp Leu Ala Asn Asn Tyr Lys Arg Asn Cys Ala Thr Phe Asn Pro Thr 
    770                 775                 780                 


Asp Asp Leu Val Leu Asn Asp Gly Val Leu Trp Asp Val Arg Ser Ala 
785                 790                 795                 800 


Gln Ala Ile His Lys Phe Asp Lys Phe Asn Met Asn Ile Ser Gly Val 
                805                 810                 815     


Phe His Pro Asn Gly Leu Glu Val Ile Ile Asn Thr Glu Ile Trp Asp 
            820                 825                 830         


Leu Arg Thr Phe His Leu Leu His Thr Val Pro Ala Leu Asp Gln Cys 
        835                 840                 845             


Arg Val Val Phe Asn His Thr Gly Thr Val Met Tyr Gly Ala Met Leu 
    850                 855                 860                 


Gln Ala Asp Asp Glu Asp Asp Leu Met Glu Glu Arg Met Lys Ser Pro 
865                 870                 875                 880 


Phe Gly Ser Ser Phe Arg Thr Phe Asn Ala Thr Asp Tyr Lys Pro Ile 
                885                 890                 895     


Ala Thr Ile Asp Val Lys Arg Asn Ile Phe Asp Leu Cys Thr Asp Thr 
            900                 905                 910         


Lys Asp Cys Tyr Leu Ala Val Ile Glu Asn Gln Gly Ser Met Asp Ala 
        915                 920                 925             


Leu Asn Met Asp Thr Val Cys Arg Leu Tyr Glu Val Gly Arg Gln Arg 
    930                 935                 940                 


Leu Ala Glu Asp Glu Asp Glu Glu Glu Asp Gln Glu Glu Glu Glu Gln 
945                 950                 955                 960 


Glu Glu Glu Asp Asp Asp Glu Asp Asp Asp Asp Thr Asp Asp Leu Asp 
                965                 970                 975     


Glu Leu Asp Thr Asp Gln Leu Leu Glu Ala Glu Leu Glu Glu Asp Asp 
            980                 985                 990         


Asn Asn Glu Asn Ala Gly Glu Asp  Gly Asp Asn Asp Phe  Ser Pro Ser 
        995                 1000                 1005             


Asp Glu  Glu Leu Ala Asn Leu  Leu Glu Glu Gly Glu  Asp Gly Glu 
    1010                 1015                 1020             


Asp Glu  Asp Ser Asp Ala Asp  Glu Glu Val Glu Leu  Ile Leu Gly 
    1025                 1030                 1035             


Asp Thr  Asp Ser Ser Asp Asn  Ser Asp Leu Glu Asp  Asp Ile Ile 
    1040                 1045                 1050             


Leu Ser  Leu Asn Glu 
    1055             


<210> 5637
<211> 802
<212> PRT
<213> Homo sapiens

<400> 5637
Met Ala Ala Glu Ala Leu Ala Ala Glu Ala Val Ala Ser Arg Leu Glu 
1               5                   10                  15      


Arg Gln Glu Glu Asp Ile Arg Trp Leu Trp Ser Glu Val Glu Arg Leu 
            20                  25                  30          


Arg Asp Glu Gln Leu Asn Ala Pro Tyr Ser Cys Gln Ala Glu Gly Pro 
        35                  40                  45              


Cys Leu Thr Arg Glu Val Ala Gln Leu Arg Ala Glu Asn Cys Asp Leu 
    50                  55                  60                  


Arg His Arg Leu Cys Ser Leu Arg Leu Cys Leu Ala Glu Glu Arg Ser 
65                  70                  75                  80  


Arg Gln Ala Thr Leu Glu Ser Ala Glu Leu Glu Ala Ala Gln Glu Ala 
                85                  90                  95      


Gly Ala Gln Pro Pro Pro Ser Gln Ser Gln Asp Lys Asp Met Lys Lys 
            100                 105                 110         


Lys Lys Met Lys Glu Ser Glu Ala Asp Ser Glu Val Lys His Gln Pro 
        115                 120                 125             


Ile Phe Ile Lys Glu Arg Leu Lys Leu Phe Glu Ile Leu Lys Lys Asp 
    130                 135                 140                 


His Gln Leu Leu Leu Ala Ile Tyr Gly Lys Lys Gly Asp Thr Ser Asn 
145                 150                 155                 160 


Ile Ile Thr Val Arg Val Ala Asp Gly Gln Thr Val Gln Gly Glu Val 
                165                 170                 175     


Trp Lys Thr Thr Pro Tyr Gln Val Ala Ala Glu Ile Ser Gln Glu Leu 
            180                 185                 190         


Ala Glu Ser Thr Val Ile Ala Lys Val Asn Gly Glu Leu Trp Asp Leu 
        195                 200                 205             


Asp Arg Pro Leu Glu Gly Asp Ser Ser Leu Glu Leu Leu Thr Phe Asp 
    210                 215                 220                 


Asn Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile Leu 
225                 230                 235                 240 


Gly Glu Ala Met Glu Leu Tyr Tyr Gly Gly His Leu Cys Tyr Gly Pro 
                245                 250                 255     


Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Phe Ile Glu Asp Arg Ala 
            260                 265                 270         


Val Ser Ser Thr Glu Leu Ser Ala Leu Glu Asn Ile Cys Lys Ala Ile 
        275                 280                 285             


Ile Lys Glu Lys Gln Pro Phe Glu Arg Leu Glu Val Ser Lys Glu Ile 
    290                 295                 300                 


Leu Leu Glu Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu Asn 
305                 310                 315                 320 


Glu Lys Val Asn Thr Ala Thr Thr Thr Val Tyr Arg Cys Gly Pro Leu 
                325                 330                 335     


Ile Asp Leu Cys Lys Gly Pro His Val Arg His Thr Gly Lys Ile Lys 
            340                 345                 350         


Thr Ile Lys Ile Phe Lys Asn Ser Ser Thr Tyr Trp Glu Gly Asn Pro 
        355                 360                 365             


Glu Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp Asn 
    370                 375                 380                 


Lys Met Met Arg Asp Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg 
385                 390                 395                 400 


Asp His Arg Lys Ile Gly Lys Glu Gln Glu Leu Phe Phe Phe His Asp 
                405                 410                 415     


Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Arg Gly Ala Phe Ile Tyr 
            420                 425                 430         


Asn Thr Leu Thr Asp Phe Ile Arg Glu Glu Tyr His Lys Arg Asp Phe 
        435                 440                 445             


Thr Glu Val Leu Ser Pro Asn Met Tyr Asn Ser Lys Leu Trp Glu Ala 
    450                 455                 460                 


Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Thr Phe Glu Ile 
465                 470                 475                 480 


Glu Lys Asp Thr Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys 
                485                 490                 495     


Leu Met Phe Ala His Arg Pro Arg Ser Trp Arg Glu Met Pro Ile Arg 
            500                 505                 510         


Phe Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Thr Leu 
        515                 520                 525             


Ser Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile 
    530                 535                 540                 


Phe Cys Thr Val Glu Gln Ile Glu Glu Glu Ile Lys Gly Cys Leu Gln 
545                 550                 555                 560 


Phe Leu Gln Ser Val Tyr Ser Thr Phe Gly Phe Ser Phe Gln Leu Asn 
                565                 570                 575     


Leu Ser Thr Arg Pro Glu Asn Phe Leu Gly Glu Ile Glu Met Trp Asn 
            580                 585                 590         


Glu Ala Glu Lys Gln Leu Gln Asn Ser Leu Met Asp Phe Gly Glu Pro 
        595                 600                 605             


Trp Lys Met Asn Pro Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp 
    610                 615                 620                 


Ile Lys Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile 
625                 630                 635                 640 


Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser 
                645                 650                 655     


Lys Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Ile His Arg Ala Ile 
            660                 665                 670         


Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Ser Glu Asn Tyr Gly 
        675                 680                 685             


Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Ile Pro 
    690                 695                 700                 


Val Gly Pro Thr Cys Glu Lys Tyr Ala Leu Gln Val Ser Ser Glu Phe 
705                 710                 715                 720 


Phe Glu Glu Gly Phe Met Ala Asp Val Asp Leu Asp His Ser Cys Thr 
                725                 730                 735     


Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile 
            740                 745                 750         


Leu Val Val Gly Glu Lys Glu Lys Ile Asp Asn Ala Val Asn Val Arg 
        755                 760                 765             


Thr Arg Asp Asn Lys Ile His Gly Glu Ile Leu Val Thr Ser Ala Ile 
    770                 775                 780                 


Asp Lys Leu Lys Asn Leu Arg Lys Thr Arg Thr Leu Asn Ala Glu Glu 
785                 790                 795                 800 


Ala Phe 
        


<210> 5638
<211> 382
<212> PRT
<213> Homo sapiens

<400> 5638
Met Phe Lys Ile Gln Leu Glu Pro Leu Lys Leu Arg Ala Trp Thr Leu 
1               5                   10                  15      


Asn Gly Phe Val Lys Phe Arg Asn Lys Glu Thr Ser Ala Gly Pro Val 
            20                  25                  30          


Ala Val Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly 
        35                  40                  45              


Ala Asn Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys 
    50                  55                  60                  


Tyr His Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys 
65                  70                  75                  80  


Glu Ile Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly 
                85                  90                  95      


Leu Tyr Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr 
            100                 105                 110         


Ser Gly Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro 
        115                 120                 125             


His Ala Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile 
    130                 135                 140                 


Phe Phe Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro 
145                 150                 155                 160 


Asp Asp Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly 
                165                 170                 175     


Arg Phe Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu 
            180                 185                 190         


Pro Leu Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu 
        195                 200                 205             


Leu Arg Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met 
    210                 215                 220                 


Lys Ile Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr 
225                 230                 235                 240 


Glu Asp Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly 
                245                 250                 255     


Thr Lys Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile 
            260                 265                 270         


Pro Ala Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe 
        275                 280                 285             


Arg Arg Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys 
    290                 295                 300                 


Glu Ala Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg 
305                 310                 315                 320 


Val Ile Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys 
                325                 330                 335     


Arg Leu Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg 
            340                 345                 350         


Gly Asp Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr 
        355                 360                 365             


Pro Gln Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
    370                 375                 380         


<210> 5639
<211> 451
<212> PRT
<213> Homo sapiens

<400> 5639
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210> 5640
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 5640
Xaa Thr Ala Arg Gly Pro Glu Pro Glu Gln Met Gly Leu Ala Pro Cys 
1               5                   10                  15      


Cys Thr Gln Ala Leu Cys Gly Leu Ala Leu Arg His His Ser His Leu 
            20                  25                  30          


Gln Gln Ile Arg Leu Glu Phe His Arg Leu Ser Glu Glu Asn Thr Leu 
        35                  40                  45              


Leu Lys Asn Asp Leu Gly Arg Val Arg Gln Glu Leu Glu Ala Ala Glu 
    50                  55                  60                  


Ser Thr His Asp Ala Gln Arg Lys Glu Ile Glu Val Leu Lys Lys Asp 
65                  70                  75                  80  


Lys Glu Lys Ala Cys Ser Glu Met Glu Val Leu Asn Arg Gln Asn Gln 
                85                  90                  95      


Asn Tyr Lys Asp Gln Leu Ser Gln Leu Asn Val Arg Val Leu Gln Leu 
            100                 105                 110         


Gly Gln Glu Ala Ser Thr His Gln Ala Gln Asn Glu Glu His Arg Val 
        115                 120                 125             


Thr Ile Gln Met Leu Thr Gln Ser Leu Glu Glu Val Val Arg Ser Gly 
    130                 135                 140                 


Gln Gln Gln 
145         


<210> 5641
<211> 256
<212> PRT
<213> Homo sapiens

<400> 5641
Met Ala Thr Gln Arg Lys His Leu Val Lys Asp Phe Asn Pro Tyr Ile 
1               5                   10                  15      


Thr Cys Tyr Ile Cys Lys Gly Tyr Leu Ile Lys Pro Thr Thr Val Thr 
            20                  25                  30          


Glu Cys Leu His Thr Phe Cys Lys Thr Cys Ile Val Gln His Phe Glu 
        35                  40                  45              


Asp Ser Asn Asp Cys Pro Arg Cys Gly Asn Gln Val His Glu Thr Asn 
    50                  55                  60                  


Pro Leu Glu Met Leu Arg Leu Asp Asn Thr Leu Glu Glu Ile Ile Phe 
65                  70                  75                  80  


Lys Leu Val Pro Gly Leu Arg Glu Gln Glu Leu Glu Arg Glu Ser Glu 
                85                  90                  95      


Phe Trp Lys Lys Asn Lys Pro Gln Glu Asn Gly Gln Asp Asp Thr Ser 
            100                 105                 110         


Lys Ala Asp Lys Pro Lys Val Asp Glu Glu Gly Asp Glu Asn Glu Asp 
        115                 120                 125             


Asp Lys Asp Tyr His Arg Ser Asp Pro Gln Ile Ala Ile Cys Leu Asp 
    130                 135                 140                 


Cys Leu Arg Asn Asn Gly Gln Ser Gly Asp Asn Val Val Lys Gly Leu 
145                 150                 155                 160 


Met Lys Lys Phe Ile Arg Cys Ser Thr Arg Val Thr Val Gly Thr Ile 
                165                 170                 175     


Lys Lys Phe Leu Ser Leu Lys Leu Lys Leu Pro Ser Ser Tyr Glu Leu 
            180                 185                 190         


Asp Val Leu Cys Asn Gly Glu Ile Met Gly Lys Asp His Thr Met Glu 
        195                 200                 205             


Phe Ile Tyr Met Thr Arg Trp Arg Leu Arg Gly Glu Asn Phe Arg Cys 
    210                 215                 220                 


Leu Asn Cys Ser Ala Ser Gln Val Cys Ser Gln Asp Gly Pro Leu Tyr 
225                 230                 235                 240 


Gln Ser Tyr Pro Met Val Leu Gln Tyr Arg Pro Arg Ile Asp Phe Gly 
                245                 250                 255     


<210> 5642
<211> 2223
<212> PRT
<213> Homo sapiens

<400> 5642
Met Ala Pro Lys Lys Glu Lys Gly Gly Thr Val Asn Thr Ser Ser Lys 
1               5                   10                  15      


Ile Trp Glu Pro Ser Leu Ile Ala Ala Gln Phe Asn Gln Asn Asp Trp 
            20                  25                  30          


Gln Ala Ser Ile Ala Phe Val Val Gly Asn Gln Ile Glu Asp Asp Leu 
        35                  40                  45              


Leu Ile Gln Ala Leu Thr Val Ala Val Gln Val Pro Gln Arg Lys Leu 
    50                  55                  60                  


Phe Ser Met Val Ser Trp Gln Asp Ile Leu Gln Gln Ile Asn Glu Ile 
65                  70                  75                  80  


Asn Thr Leu Val Gly Ser Ala Ser Ser Lys Lys Ala Lys Lys Pro Val 
                85                  90                  95      


Gly Gly Asn Ala Pro Leu Tyr Tyr Glu Val Leu Thr Ala Ala Lys Ala 
            100                 105                 110         


Ile Met Asp Ser Gly Glu Lys Leu Thr Leu Pro Leu Ile Gly Lys Leu 
        115                 120                 125             


Leu Lys Phe Gln Leu Leu Gln Ile Lys Phe Lys Asp Gln Gln Arg Arg 
    130                 135                 140                 


Glu Asn Glu Lys Lys Val Ile Glu Asp Lys Pro Lys Leu Glu Lys Asp 
145                 150                 155                 160 


Lys Gly Lys Ala Lys Ser Pro Lys Glu Lys Lys Ala Pro Ser Ala Lys 
                165                 170                 175     


Pro Ala Lys Gly Lys Gly Lys Asp Gln Pro Glu Ala Asn Ala Pro Val 
            180                 185                 190         


Lys Lys Thr Thr Gln Leu Lys Arg Arg Gly Glu Asp Asp His Thr Asn 
        195                 200                 205             


Arg Tyr Ile Asp Asp Glu Pro Asp Asp Gly Ala Gln His Tyr Ile Ile 
    210                 215                 220                 


Val Val Gly Phe Asn Asn Pro Gln Leu Leu Ala Ile Met Ala Glu Leu 
225                 230                 235                 240 


Gly Ile Pro Ile Thr Ser Val Ile Lys Ile Ser Ser Glu Asn Tyr Glu 
                245                 250                 255     


Pro Leu Gln Thr His Leu Ala Ala Val Asn Gln Gln Gln Glu Val Leu 
            260                 265                 270         


Leu Gln Ser Glu Asp Leu Glu Ala Glu Lys Leu Lys Lys Glu Asn Ala 
        275                 280                 285             


Ile Lys Glu Leu Lys Thr Phe Trp Lys Tyr Leu Glu Pro Val Leu Asn 
    290                 295                 300                 


Asn Glu Lys Pro Glu Thr Asn Leu Phe Asp Val Ala Arg Leu Glu Tyr 
305                 310                 315                 320 


Met Val Lys Ala Ala Asp Phe Pro Ser Asp Trp Ser Asp Gly Glu Met 
                325                 330                 335     


Met Leu Lys Leu Gly Thr Asp Ile Phe Glu Asn Ile Ala Cys Leu Met 
            340                 345                 350         


Tyr Asp Ile Leu Asp Trp Lys Arg Gln His Gln His Tyr Leu Glu Ser 
        355                 360                 365             


Met Gln Leu Ile Asn Val Pro Gln Val Val Asn Glu Lys Pro Val Leu 
    370                 375                 380                 


Glu Ala Met Pro Thr Ser Glu Ala Pro Gln Pro Ala Val Pro Ala Pro 
385                 390                 395                 400 


Gly Lys Lys Lys Ala Gln Tyr Glu Glu Pro Gln Ala Pro Pro Pro Val 
                405                 410                 415     


Thr Ser Val Ile Thr Thr Glu Val Asp Met Arg Tyr Tyr Asn Tyr Leu 
            420                 425                 430         


Leu Asn Pro Ile Arg Glu Glu Phe Ile Ser Val Pro Leu Ile Leu His 
        435                 440                 445             


Cys Met Leu Glu Gln Val Val Ala Thr Glu Glu Asp Leu Val Pro Pro 
    450                 455                 460                 


Ser Leu Arg Glu Pro Ser Pro Arg Ala Asp Gly Leu Asp His Arg Ile 
465                 470                 475                 480 


Ala Ala His Ile Val Ser Leu Leu Pro Ser Leu Cys Leu Ser Glu Arg 
                485                 490                 495     


Glu Lys Lys Asn Leu His Asp Ile Phe Leu Ser Glu Glu Glu Asn Glu 
            500                 505                 510         


Ser Lys Ala Val Pro Lys Gly Pro Leu Leu Leu Asn Tyr His Asp Ala 
        515                 520                 525             


His Ala His Lys Lys Tyr Ala Leu Gln Asp Gln Lys Asn Phe Asp Pro 
    530                 535                 540                 


Val Gln Ile Glu Gln Glu Met Gln Ser Lys Leu Pro Leu Trp Glu Phe 
545                 550                 555                 560 


Leu Gln Phe Pro Leu Pro Pro Pro Trp Asn Asn Thr Lys Arg Leu Ala 
                565                 570                 575     


Thr Ile His Glu Leu Met His Phe Cys Thr Ser Asp Val Leu Ser Trp 
            580                 585                 590         


Asn Glu Val Glu Arg Ala Phe Lys Val Phe Thr Phe Glu Ser Leu Lys 
        595                 600                 605             


Leu Ser Glu Val Asp Glu Lys Gly Lys Leu Lys Pro Ser Gly Met Met 
    610                 615                 620                 


Cys Gly Ser Asp Ser Glu Met Phe Asn Ile Pro Trp Asp Asn Pro Ala 
625                 630                 635                 640 


Arg Phe Ala Lys Gln Ile Arg Gln Gln Tyr Val Met Lys Met Asn Thr 
                645                 650                 655     


Gln Glu Ala Lys Gln Lys Ala Asp Ile Lys Ile Lys Asp Arg Thr Leu 
            660                 665                 670         


Phe Val Asp Gln Asn Leu Ser Met Ser Val Gln Asp Asn Glu Ser Asn 
        675                 680                 685             


Arg Glu Pro Ser Asp Pro Ser Gln Cys Asp Ala Asn Asn Met Lys His 
    690                 695                 700                 


Ser Asp Leu Asn Asn Leu Lys Leu Ser Val Pro Asp Asn Arg Gln Leu 
705                 710                 715                 720 


Leu Glu Gln Glu Ser Ile Met Lys Ala Gln Pro Gln His Glu Ser Leu 
                725                 730                 735     


Glu Gln Thr Thr Asn Asn Glu Ile Lys Asp Asp Ala Val Thr Lys Ala 
            740                 745                 750         


Asp Ser His Glu Lys Lys Pro Lys Lys Met Met Val Glu Ala Asp Leu 
        755                 760                 765             


Glu Asp Ile Lys Lys Thr Gln Gln Arg Ser Leu Met Asp Trp Ser Phe 
    770                 775                 780                 


Thr Glu His Phe Lys Pro Lys Val Leu Leu Gln Val Leu Gln Glu Ala 
785                 790                 795                 800 


His Lys Gln Tyr Arg Cys Val Asp Ser Tyr Tyr His Thr Gln Asp Asn 
                805                 810                 815     


Ser Leu Leu Leu Val Phe His Asn Pro Met Asn Arg Gln Arg Leu His 
            820                 825                 830         


Cys Glu Tyr Trp Asn Ile Ala Leu His Ser Asn Val Gly Phe Arg Asn 
        835                 840                 845             


Tyr Leu Glu Leu Val Ala Lys Ser Ile Gln Asp Trp Ile Thr Lys Glu 
    850                 855                 860                 


Glu Ala Ile Tyr Gln Glu Ser Lys Met Asn Glu Lys Ile Ile Arg Thr 
865                 870                 875                 880 


Arg Ala Glu Leu Glu Leu Lys Ser Ser Ala Asn Ala Lys Leu Thr Ser 
                885                 890                 895     


Ala Ser Lys Ile Phe Ser Ile Lys Glu Ser Lys Ser Asn Lys Gly Ile 
            900                 905                 910         


Ser Lys Thr Glu Ile Ser Asp Gln Glu Lys Glu Lys Glu Lys Glu Lys 
        915                 920                 925             


Ile Pro Phe Ile Leu Glu Gly Ser Leu Lys Ala Trp Lys Glu Glu Gln 
    930                 935                 940                 


His Arg Leu Ala Glu Glu Glu Arg Leu Arg Glu Glu Lys Lys Ala Glu 
945                 950                 955                 960 


Lys Lys Gly Lys Glu Ala Gly Lys Lys Lys Gly Lys Asp Asn Ala Glu 
                965                 970                 975     


Lys Glu Asp Ser Arg Ser Leu Lys Lys Lys Ser Pro Tyr Lys Glu Lys 
            980                 985                 990         


Ser Lys Glu Glu Gln Val Lys Ile  Gln Glu Val Thr Glu  Glu Ser Pro 
        995                 1000                 1005             


His Gln  Pro Glu Pro Lys Ile  Thr Tyr Pro Phe His  Gly Tyr Asn 
    1010                 1015                 1020             


Met Gly  Asn Ile Pro Thr Gln  Ile Ser Gly Ser Asn  Tyr Tyr Leu 
    1025                 1030                 1035             


Tyr Pro  Ser Asp Gly Gly Gln  Ile Glu Val Glu Lys  Thr Met Phe 
    1040                 1045                 1050             


Glu Lys  Gly Pro Thr Phe Ile  Lys Val Arg Val Val  Lys Asp Asn 
    1055                 1060                 1065             


His Asn  Phe Met Ile His Leu  Asn Asp Pro Lys Glu  Ile Val Lys 
    1070                 1075                 1080             


Lys Glu  Glu Lys Gly Asp Tyr  Tyr Leu Glu Glu Glu  Glu Glu Gly 
    1085                 1090                 1095             


Asp Glu  Glu Gln Ser Leu Glu  Thr Glu Val Ser Asp  Ala Lys Asn 
    1100                 1105                 1110             


Lys Ala  Phe Ser Lys Phe Gly  Ser Phe Ser Ala Thr  Leu Glu Asn 
    1115                 1120                 1125             


Gly Ile  Cys Leu Ser Ile Ser  Tyr Tyr Gly Ser Asn  Gly Met Ala 
    1130                 1135                 1140             


Pro Glu  Asp Lys Asp Pro Asp  Leu Glu Thr Ile Leu  Asn Ile Pro 
    1145                 1150                 1155             


Ser Ala  Leu Thr Pro Thr Val  Val Pro Val Ile Val  Thr Val Pro 
    1160                 1165                 1170             


Gln Ser  Lys Ala Lys Gly Lys  Ile Lys Gly Lys Glu  Lys Pro Lys 
    1175                 1180                 1185             


Glu Ser  Leu Lys Glu Glu Glu  His Pro Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Val Glu Pro Glu  Pro Val Leu Gln Glu  Thr Leu Asp 
    1205                 1210                 1215             


Val Pro  Thr Phe Gln Ser Leu  Asn Val Ser Cys Pro  Ser Gly Leu 
    1220                 1225                 1230             


Leu Leu  Thr Phe Ile Gly Gln  Glu Ser Thr Gly Gln  Tyr Val Ile 
    1235                 1240                 1245             


Asp Glu  Glu Pro Thr Trp Asp  Ile Met Val Arg Gln  Ser Tyr Pro 
    1250                 1255                 1260             


Gln Arg  Val Lys His Tyr Glu  Phe Tyr Lys Thr Val  Met Pro Pro 
    1265                 1270                 1275             


Ala Glu  Gln Glu Ala Ser Arg  Val Ile Thr Ser Gln  Gly Thr Val 
    1280                 1285                 1290             


Val Lys  Tyr Met Leu Asp Gly  Ser Thr Gln Ile Leu  Phe Ala Asp 
    1295                 1300                 1305             


Gly Ala  Val Ser Arg Ser Pro  Asn Ser Gly Leu Ile  Cys Pro Pro 
    1310                 1315                 1320             


Ser Glu  Met Pro Ala Thr Pro  His Ser Gly Asp Leu  Met Asp Ser 
    1325                 1330                 1335             


Ile Ser  Gln Gln Lys Ser Glu  Thr Ile Pro Ser Glu  Ile Thr Asn 
    1340                 1345                 1350             


Thr Lys  Lys Gly Lys Ser His  Lys Ser Gln Ser Ser  Met Ala His 
    1355                 1360                 1365             


Lys Gly  Glu Ile His Asp Pro  Pro Pro Glu Ala Val  Gln Thr Val 
    1370                 1375                 1380             


Thr Pro  Val Glu Val His Ile  Gly Thr Trp Phe Thr  Thr Thr Pro 
    1385                 1390                 1395             


Glu Gly  Asn Arg Ile Gly Thr  Lys Gly Leu Glu Arg  Ile Ala Asp 
    1400                 1405                 1410             


Leu Thr  Pro Leu Leu Ser Phe  Gln Ala Thr Asp Pro  Val Asn Gly 
    1415                 1420                 1425             


Thr Val  Met Thr Thr Arg Glu  Asp Lys Val Val Ile  Val Glu Arg 
    1430                 1435                 1440             


Lys Asp  Gly Thr Arg Ile Val  Asp His Ala Asp Gly  Thr Arg Ile 
    1445                 1450                 1455             


Thr Thr  Phe Tyr Gln Val Tyr  Glu Asp Gln Ile Ile  Leu Pro Asp 
    1460                 1465                 1470             


Asp Gln  Glu Thr Thr Glu Gly  Pro Arg Thr Val Thr  Arg Gln Val 
    1475                 1480                 1485             


Lys Cys  Met Arg Val Glu Ser  Ser Arg Tyr Ala Thr  Val Ile Ala 
    1490                 1495                 1500             


Asn Cys  Glu Asp Ser Ser Cys  Cys Ala Thr Phe Gly  Asp Gly Thr 
    1505                 1510                 1515             


Thr Ile  Ile Ala Lys Pro Gln  Gly Thr Tyr Gln Val  Leu Pro Pro 
    1520                 1525                 1530             


Asn Thr  Gly Ser Leu Tyr Ile  Asp Lys Asp Cys Ser  Ala Val Tyr 
    1535                 1540                 1545             


Cys His  Glu Ser Ser Ser Asn  Ile Tyr Tyr Pro Phe  Gln Lys Arg 
    1550                 1555                 1560             


Glu Gln  Leu Arg Ala Gly Arg  Tyr Ile Met Arg His  Thr Ser Glu 
    1565                 1570                 1575             


Val Ile  Cys Glu Val Leu Asp  Pro Glu Gly Asn Thr  Phe Gln Val 
    1580                 1585                 1590             


Met Ala  Asp Gly Ser Ile Ser  Thr Ile Leu Pro Glu  Lys Lys Leu 
    1595                 1600                 1605             


Glu Asp  Asp Leu Asn Glu Lys  Thr Glu Gly Tyr Asp  Ser Leu Ser 
    1610                 1615                 1620             


Ser Met  His Leu Glu Lys Asn  His Gln Gln Ile Tyr  Gly Glu His 
    1625                 1630                 1635             


Val Pro  Arg Phe Phe Val Met  Tyr Ala Asp Gly Ser  Gly Met Glu 
    1640                 1645                 1650             


Leu Leu  Arg Asp Ser Asp Ile  Glu Glu Tyr Leu Ser  Leu Ala Tyr 
    1655                 1660                 1665             


Lys Glu  Ser Asn Thr Val Val  Leu Gln Glu Pro Val  Gln Glu Gln 
    1670                 1675                 1680             


Pro Gly  Thr Leu Thr Ile Thr  Val Leu Arg Pro Phe  His Glu Ala 
    1685                 1690                 1695             


Ser Pro  Trp Gln Val Lys Lys  Glu Asp Thr Ile Val  Pro Pro Asn 
    1700                 1705                 1710             


Leu Arg  Ser Arg Ser Trp Glu  Thr Phe Pro Ser Val  Glu Lys Lys 
    1715                 1720                 1725             


Thr Pro  Gly Pro Pro Phe Gly  Thr Gln Ile Trp Lys  Gly Leu Cys 
    1730                 1735                 1740             


Ile Glu  Ser Lys Gln Leu Val  Ser Ala Pro Gly Ala  Ile Leu Lys 
    1745                 1750                 1755             


Ser Pro  Ser Val Leu Gln Met  Arg Gln Phe Ile Gln  His Glu Val 
    1760                 1765                 1770             


Ile Lys  Asn Glu Val Lys Leu  Arg Leu Gln Val Ser  Leu Lys Asp 
    1775                 1780                 1785             


Tyr Ile  Asn Tyr Ile Leu Lys  Lys Glu Asp Glu Leu  Gln Glu Met 
    1790                 1795                 1800             


Met Val  Lys Asp Ser Arg Thr  Glu Glu Glu Arg Gly  Asn Ala Ala 
    1805                 1810                 1815             


Asp Leu  Leu Lys Leu Val Met  Ser Phe Pro Lys Met  Glu Glu Thr 
    1820                 1825                 1830             


Thr Lys  Ser His Val Thr Glu  Val Ala Ala His Leu  Thr Asp Leu 
    1835                 1840                 1845             


Phe Lys  Gln Ser Leu Ala Thr  Pro Pro Lys Cys Pro  Pro Asp Thr 
    1850                 1855                 1860             


Phe Gly  Lys Asp Phe Phe Glu  Lys Thr Trp Arg His  Thr Ala Ser 
    1865                 1870                 1875             


Ser Lys  Arg Trp Lys Glu Lys  Ile Asp Lys Thr Arg  Lys Glu Ile 
    1880                 1885                 1890             


Glu Thr  Thr Gln Asn Tyr Leu  Met Asp Ile Lys Asn  Arg Ile Ile 
    1895                 1900                 1905             


Pro Pro  Phe Phe Lys Ser Glu  Leu Asn Gln Leu Tyr  Gln Ser Gln 
    1910                 1915                 1920             


Tyr Asn  His Leu Asp Ser Leu  Ser Lys Lys Leu Pro  Ser Phe Thr 
    1925                 1930                 1935             


Lys Lys  Asn Glu Asp Ala Asn  Glu Thr Ala Val Gln  Asp Thr Ser 
    1940                 1945                 1950             


Asp Leu  Asn Leu Asp Phe Lys  Pro His Lys Val Ser  Glu Gln Lys 
    1955                 1960                 1965             


Ser Ser  Ser Val Pro Ser Leu  Pro Lys Pro Glu Ile  Ser Ala Asp 
    1970                 1975                 1980             


Lys Lys  Asp Phe Thr Ala Gln  Asn Gln Thr Glu Asn  Leu Thr Lys 
    1985                 1990                 1995             


Ser Pro  Glu Glu Ala Glu Ser  Tyr Glu Pro Val Lys  Ile Pro Thr 
    2000                 2005                 2010             


Gln Ser  Leu Leu Gln Asp Val  Ala Gly Gln Thr Arg  Lys Glu Lys 
    2015                 2020                 2025             


Val Lys  Leu Pro His Tyr Leu  Leu Ser Ser Lys Pro  Lys Ser Gln 
    2030                 2035                 2040             


Pro Leu  Ala Lys Val Gln Asp  Ser Val Gly Gly Lys  Val Asn Thr 
    2045                 2050                 2055             


Ser Ser  Val Ala Ser Ala Ala  Ile Asn Asn Ala Lys  Ser Ser Leu 
    2060                 2065                 2070             


Phe Gly  Phe His Leu Leu Pro  Ser Ser Val Lys Phe  Gly Val Leu 
    2075                 2080                 2085             


Lys Glu  Gly His Thr Tyr Ala  Thr Val Val Lys Leu  Lys Asn Val 
    2090                 2095                 2100             


Gly Val  Asp Phe Cys Arg Phe  Lys Val Lys Gln Pro  Pro Pro Ser 
    2105                 2110                 2115             


Thr Gly  Leu Lys Val Thr Tyr  Lys Pro Gly Pro Val  Ala Ala Gly 
    2120                 2125                 2130             


Met Gln  Thr Glu Leu Asn Ile  Glu Leu Phe Ala Thr  Ala Val Gly 
    2135                 2140                 2145             


Glu Asp  Gly Ala Lys Gly Ser  Ala His Ile Ser His  Asn Ile Glu 
    2150                 2155                 2160             


Ile Met  Thr Glu His Glu Val  Leu Phe Leu Pro Val  Glu Ala Thr 
    2165                 2170                 2175             


Val Leu  Thr Ser Ser Asn Tyr  Asp Lys Arg Pro Lys  Asp Phe Pro 
    2180                 2185                 2190             


Gln Gly  Lys Glu Asn Pro Met  Val Gln Arg Thr Ser  Thr Ile Tyr 
    2195                 2200                 2205             


Ser Ser  Thr Leu Gly Val Phe  Met Ser Arg Lys Val  Ser Pro His 
    2210                 2215                 2220             


<210> 5643
<211> 778
<212> PRT
<213> Homo sapiens

<400> 5643
Met Pro Ala Phe Leu Gly Leu Lys Cys Leu Gly Lys Leu Cys Ser Ser 
1               5                   10                  15      


Glu Lys Ser Lys Val Thr Ser Ser Glu Arg Thr Ser Ala Arg Gly Ser 
            20                  25                  30          


Asn Arg Lys Arg Leu Ile Val Glu Asp Arg Arg Val Ser Gly Thr Ser 
        35                  40                  45              


Phe Thr Ala His Arg Arg Ala Thr Ile Thr His Leu Leu Tyr Leu Cys 
    50                  55                  60                  


Pro Lys Asp Tyr Cys Pro Arg Gly Arg Val Cys Asn Ser Val Asp Pro 
65                  70                  75                  80  


Phe Val Ala His Pro Gln Asp Pro His His Pro Ser Glu Lys Pro Val 
                85                  90                  95      


Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly Glu Val Leu Arg 
            100                 105                 110         


Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr Cys Lys Val Cys 
        115                 120                 125             


Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys Asn Gly Glu Tyr 
    130                 135                 140                 


Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr Arg Cys His Gly 
145                 150                 155                 160 


Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala Leu Gly Lys Thr 
                165                 170                 175     


Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys Arg Pro Phe Pro 
            180                 185                 190         


Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys Leu Cys Gln Leu 
        195                 200                 205             


Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr Thr Phe Ser Ser 
    210                 215                 220                 


Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly Gln Ala Leu Leu 
225                 230                 235                 240 


Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys Cys Lys Ser Cys 
                245                 250                 255     


Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp Gly Ala Pro Tyr 
            260                 265                 270         


Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys Cys Glu Ala Cys 
        275                 280                 285             


His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly Asp Lys His Tyr 
    290                 295                 300                 


His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln Met Phe Thr Glu 
305                 310                 315                 320 


Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp His Pro Asp Cys 
                325                 330                 335     


Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro Thr Arg Thr Ser 
            340                 345                 350         


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
        355                 360                 365             


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
    370                 375                 380                 


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
385                 390                 395                 400 


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
                405                 410                 415     


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
            420                 425                 430         


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
        435                 440                 445             


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
    450                 455                 460                 


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
465                 470                 475                 480 


Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu Pro Tyr Arg Pro 
                485                 490                 495     


Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala Pro Lys His Phe 
            500                 505                 510         


His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr 
        515                 520                 525             


Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile 
    530                 535                 540                 


Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu 
545                 550                 555                 560 


Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala 
                565                 570                 575     


Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp 
            580                 585                 590         


Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met 
        595                 600                 605             


Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu 
    610                 615                 620                 


Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser 
625                 630                 635                 640 


Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu 
                645                 650                 655     


Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe 
            660                 665                 670         


Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Tyr 
        675                 680                 685             


Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly 
    690                 695                 700                 


Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met 
705                 710                 715                 720 


Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp 
                725                 730                 735     


Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile 
            740                 745                 750         


Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg 
        755                 760                 765             


Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
    770                 775             


<210> 5644
<211> 562
<212> PRT
<213> Homo sapiens

<400> 5644
Met Asn Pro Leu Phe Gly Pro Asn Leu Phe Leu Leu Gln Gln Glu Gln 
1               5                   10                  15      


Gln Gly Leu Ala Gly Pro Leu Gly Asp Ser Leu Gly Gly Asp His Phe 
            20                  25                  30          


Ala Gly Gly Gly Asp Leu Pro Pro Ala Pro Leu Ser Pro Ala Gly Pro 
        35                  40                  45              


Ala Ala Tyr Ser Pro Pro Gly Pro Gly Pro Ala Pro Pro Ala Ala Met 
    50                  55                  60                  


Ala Leu Arg Asn Asp Leu Gly Ser Asn Ile Asn Val Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Leu Arg Phe Arg Cys Phe Leu Ala Lys Val His Glu Leu Glu Arg 
                85                  90                  95      


Arg Asn Arg Leu Leu Glu Lys Gln Leu Gln Gln Ala Leu Glu Glu Gly 
            100                 105                 110         


Lys Gln Gly Arg Arg Gly Leu Gly Arg Arg Asp Gln Ala Val Gln Thr 
        115                 120                 125             


Gly Phe Val Ser Pro Ile Arg Pro Leu Gly Leu Gln Leu Gly Ala Arg 
    130                 135                 140                 


Pro Ala Ala Val Cys Ser Pro Ser Ala Arg Val Leu Gly Ser Pro Ala 
145                 150                 155                 160 


Arg Ser Pro Ala Gly Pro Leu Ala Pro Ser Ala Ala Ser Leu Ser Ser 
                165                 170                 175     


Ser Ser Thr Ser Thr Ser Thr Thr Tyr Ser Ser Ser Ala Arg Phe Met 
            180                 185                 190         


Pro Gly Thr Ile Trp Ser Phe Ser His Ala Arg Arg Leu Gly Pro Gly 
        195                 200                 205             


Leu Glu Pro Thr Leu Val Gln Gly Pro Gly Leu Ser Trp Val His Pro 
    210                 215                 220                 


Asp Gly Val Gly Val Gln Ile Asp Thr Ile Thr Pro Glu Ile Arg Ala 
225                 230                 235                 240 


Leu Tyr Asn Val Leu Ala Lys Val Lys Arg Glu Arg Asp Glu Tyr Lys 
                245                 250                 255     


Arg Arg Trp Glu Glu Glu Tyr Thr Val Arg Ile Gln Leu Gln Asp Arg 
            260                 265                 270         


Val Asn Glu Leu Gln Glu Glu Ala Gln Glu Ala Asp Ala Cys Gln Glu 
        275                 280                 285             


Glu Leu Ala Leu Lys Val Glu Gln Leu Lys Ala Glu Leu Val Val Phe 
    290                 295                 300                 


Lys Gly Leu Met Ser Asn Asn Leu Ser Glu Leu Asp Thr Lys Ile Gln 
305                 310                 315                 320 


Glu Lys Ala Met Lys Val Asp Met Asp Ile Cys Arg Arg Ile Asp Ile 
                325                 330                 335     


Thr Ala Lys Leu Cys Asp Val Ala Gln Gln Arg Asn Cys Glu Asp Met 
            340                 345                 350         


Ile Gln Met Phe Gln Lys Lys Leu Val Pro Ser Met Gly Gly Arg Lys 
        355                 360                 365             


Arg Glu Arg Lys Ala Ala Val Glu Glu Asp Thr Ser Leu Ser Glu Ser 
    370                 375                 380                 


Glu Gly Pro Arg Gln Pro Asp Gly Asp Glu Glu Glu Ser Thr Ala Leu 
385                 390                 395                 400 


Ser Ile Asn Glu Glu Met Gln Arg Met Leu Asn Gln Leu Arg Glu Tyr 
                405                 410                 415     


Asp Phe Glu Asp Asp Cys Asp Ser Leu Thr Trp Glu Glu Thr Glu Glu 
            420                 425                 430         


Thr Leu Leu Leu Trp Glu Asp Phe Ser Gly Tyr Ala Met Ala Ala Ala 
        435                 440                 445             


Glu Ala Gln Gly Glu Gln Glu Asp Ser Leu Glu Lys Val Ile Lys Asp 
    450                 455                 460                 


Thr Glu Ser Leu Phe Lys Thr Arg Glu Lys Glu Tyr Gln Glu Thr Ile 
465                 470                 475                 480 


Asp Gln Ile Glu Leu Glu Leu Ala Thr Ala Lys Asn Asp Met Asn Arg 
                485                 490                 495     


His Leu His Glu Tyr Met Glu Met Cys Ser Met Lys Arg Gly Leu Asp 
            500                 505                 510         


Val Gln Met Glu Thr Cys Arg Arg Leu Ile Thr Gln Ser Gly Asp Arg 
        515                 520                 525             


Lys Ser Pro Ala Phe Thr Ala Val Pro Leu Ser Asp Pro Pro Pro Pro 
    530                 535                 540                 


Pro Ser Glu Ala Glu Asp Ser Asp Arg Asp Val Ser Ser Asp Ser Ser 
545                 550                 555                 560 


Met Arg 
        


<210> 5645
<211> 804
<212> PRT
<213> Homo sapiens

<400> 5645
Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Asp Thr Gly Leu Gly Asp Ser 
        435                 440                 445             


Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asp 
    450                 455                 460                 


Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys 
465                 470                 475                 480 


Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly Thr Ala Glu Glu 
                485                 490                 495     


Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu Thr Gly Gln Thr 
            500                 505                 510         


Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln 
        515                 520                 525             


Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser 
    530                 535                 540                 


Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln 
545                 550                 555                 560 


Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys Val Asp Cys Glu Thr 
                565                 570                 575     


Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile 
            580                 585                 590         


Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr His Leu Ser Arg Val 
        595                 600                 605             


Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu Leu Ile Lys Val Met 
    610                 615                 620                 


Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val Trp Glu Glu Ser Ser 
625                 630                 635                 640 


Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr Arg Glu Glu Lys Glu 
                645                 650                 655     


Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu 
            660                 665                 670         


Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala 
        675                 680                 685             


Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg 
    690                 695                 700                 


Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly Arg Thr Ala Leu 
705                 710                 715                 720 


His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile 
                725                 730                 735     


Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala His Gly Asn Thr Ala 
            740                 745                 750         


Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asp Val Leu 
        755                 760                 765             


Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu Met Ala Thr Pro 
    770                 775                 780                 


Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser Ser Gly Arg Val 
785                 790                 795                 800 


Pro Thr Ile Ile 
                


<210> 5646
<211> 903
<212> PRT
<213> Homo sapiens

<400> 5646
Met Pro Glu Gln Phe Ser Val Ala Glu Phe Leu Ala Val Thr Ala Glu 
1               5                   10                  15      


Asp Leu Ser Ser Pro Ala Gly Ala Ala Ala Phe Ala Ala Lys Met Pro 
            20                  25                  30          


Arg Tyr Arg Gly Ala Ala Leu Ala Arg Glu Glu Ile Leu Glu Gly Asp 
        35                  40                  45              


Gln Ala Ile Leu Gln Arg Ile Lys Lys Ala Val Arg Ala Ile His Ser 
    50                  55                  60                  


Ser Gly Leu Gly His Val Glu Asn Glu Glu Gln Tyr Arg Glu Ala Val 
65                  70                  75                  80  


Glu Ser Leu Gly Asn Ser His Leu Ser Gln Asn Ser His Glu Leu Ser 
                85                  90                  95      


Thr Gly Phe Leu Asn Leu Ala Val Phe Thr Arg Glu Val Ala Ala Leu 
            100                 105                 110         


Phe Lys Asn Leu Ile Gln Asn Leu Asn Asn Ile Val Ser Phe Pro Leu 
        115                 120                 125             


Asp Ser Leu Met Lys Gly Gln Leu Arg Asp Gly Arg Gln Asp Ser Lys 
    130                 135                 140                 


Lys Gln Leu Glu Lys Ala Trp Lys Asp Tyr Glu Ala Lys Met Ala Lys 
145                 150                 155                 160 


Leu Glu Lys Glu Arg Asp Arg Ala Arg Val Thr Gly Gly Ile Pro Gly 
                165                 170                 175     


Glu Val Ala Gln Asp Met Gln Arg Glu Arg Arg Ile Phe Gln Leu His 
            180                 185                 190         


Met Cys Glu Tyr Leu Leu Lys Ala Gly Glu Ser Gln Met Lys Gln Gly 
        195                 200                 205             


Pro Asp Phe Leu Gln Ser Leu Ile Lys Phe Phe His Ala Gln His Asn 
    210                 215                 220                 


Phe Phe Gln Asp Gly Trp Lys Ala Ala Gln Ser Leu Phe Pro Phe Ile 
225                 230                 235                 240 


Glu Lys Leu Ala Ala Ser Val His Ala Leu His Gln Ala Gln Glu Asp 
                245                 250                 255     


Glu Leu Gln Lys Leu Thr Gln Leu Arg Asp Ser Leu Arg Gly Thr Leu 
            260                 265                 270         


Gln Leu Glu Ser Arg Glu Glu His Leu Ser Arg Lys Asn Ser Gly Cys 
        275                 280                 285             


Gly Tyr Ser Ile His Gln His Gln Gly Asn Lys Gln Phe Gly Thr Glu 
    290                 295                 300                 


Lys Val Gly Phe Leu Tyr Lys Lys Ser Asp Gly Ile Arg Arg Val Trp 
305                 310                 315                 320 


Gln Lys Arg Lys Cys Gly Val Lys Tyr Gly Cys Leu Thr Ile Ser His 
                325                 330                 335     


Ser Thr Ile Asn Arg Pro Pro Val Lys Leu Thr Leu Leu Thr Cys Gln 
            340                 345                 350         


Val Arg Pro Asn Pro Glu Glu Lys Lys Cys Phe Asp Leu Val Thr His 
        355                 360                 365             


Asn Arg Thr Tyr His Phe Gln Ala Glu Asp Glu His Glu Cys Glu Ala 
    370                 375                 380                 


Trp Val Ser Val Leu Gln Asn Ser Lys Asp Glu Ala Leu Ser Ser Ala 
385                 390                 395                 400 


Phe Leu Gly Glu Pro Ser Ala Gly Pro Gly Ser Trp Gly Ser Ala Gly 
                405                 410                 415     


His Asp Gly Glu Pro His Asp Leu Thr Lys Leu Leu Ile Ala Glu Val 
            420                 425                 430         


Lys Ser Arg Pro Gly Asn Ser Gln Cys Cys Asp Cys Gly Ala Ala Asp 
        435                 440                 445             


Pro Thr Trp Leu Ser Thr Asn Leu Gly Val Leu Thr Cys Ile Gln Cys 
    450                 455                 460                 


Ser Gly Val His Arg Glu Leu Gly Val Arg Phe Ser Arg Met Gln Ser 
465                 470                 475                 480 


Leu Thr Leu Asp Leu Leu Gly Pro Ser Glu Leu Leu Leu Ala Leu Asn 
                485                 490                 495     


Met Gly Asn Thr Ser Phe Asn Glu Val Met Glu Ala Gln Leu Pro Ser 
            500                 505                 510         


His Gly Gly Pro Lys Pro Ser Ala Glu Ser Asp Met Gly Thr Arg Arg 
        515                 520                 525             


Asp Tyr Ile Met Ala Lys Tyr Val Glu His Arg Phe Ala Arg Arg Cys 
    530                 535                 540                 


Thr Pro Glu Pro Gln Arg Leu Trp Thr Ala Ile Cys Asn Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Val Leu Glu Ala Phe Ala Asn Gly Gln Asp Phe Gly Gln Pro 
                565                 570                 575     


Leu Pro Gly Pro Asp Ala Gln Ala Pro Glu Glu Leu Val Leu His Leu 
            580                 585                 590         


Ala Val Lys Val Ala Asn Gln Ala Ser Leu Pro Leu Val Asp Phe Ile 
        595                 600                 605             


Ile Gln Asn Gly Gly His Leu Asp Ala Lys Ala Ala Asp Gly Asn Thr 
    610                 615                 620                 


Ala Leu His Tyr Ala Ala Leu Tyr Asn Gln Pro Asp Cys Leu Lys Leu 
625                 630                 635                 640 


Leu Leu Lys Gly Arg Ala Leu Val Gly Thr Val Asn Glu Ala Gly Glu 
                645                 650                 655     


Thr Ala Leu Asp Ile Ala Arg Lys Lys His His Lys Glu Cys Glu Glu 
            660                 665                 670         


Leu Leu Glu Gln Ala Gln Ala Gly Thr Phe Ala Phe Pro Leu His Val 
        675                 680                 685             


Asp Tyr Ser Trp Val Ile Ser Thr Glu Pro Gly Ser Asp Ser Glu Glu 
    690                 695                 700                 


Asp Glu Glu Glu Lys Arg Cys Leu Leu Lys Leu Pro Ala Gln Ala His 
705                 710                 715                 720 


Trp Ala Ser Gly Arg Leu Asp Ile Ser Asn Lys Thr Tyr Glu Thr Val 
                725                 730                 735     


Ala Ser Leu Gly Ala Ala Thr Pro Gln Gly Glu Ser Glu Asp Cys Pro 
            740                 745                 750         


Pro Pro Leu Pro Val Lys Asn Ser Ser Arg Thr Leu Val Gln Gly Cys 
        755                 760                 765             


Ala Arg His Ala Ser Gly Asp Arg Ser Glu Val Ser Ser Leu Ser Ser 
    770                 775                 780                 


Glu Ala Pro Glu Thr Pro Glu Ser Leu Gly Ser Pro Ala Ser Ser Ser 
785                 790                 795                 800 


Ser Leu Met Ser Pro Leu Glu Pro Gly Asp Pro Ser Gln Ala Pro Pro 
                805                 810                 815     


Asn Ser Glu Glu Gly Leu Arg Glu Pro Pro Gly Thr Ser Arg Pro Ser 
            820                 825                 830         


Leu Thr Ser Gly Thr Thr Pro Ser Glu Met Tyr Leu Pro Val Arg Phe 
        835                 840                 845             


Ser Ser Glu Ser Thr Arg Ser Tyr Arg Arg Gly Ala Arg Ser Pro Glu 
    850                 855                 860                 


Asp Gly Pro Ser Ala Arg Gln Pro Leu Pro Arg Arg Asn Val Pro Val 
865                 870                 875                 880 


Gly Ile Thr Glu Gly Asp Gly Ser Arg Thr Gly Ser Leu Pro Ala Ser 
                885                 890                 895     


Ser Val Gln Leu Leu Gln Asp 
            900             


<210> 5647
<211> 452
<212> PRT
<213> Homo sapiens

<400> 5647
Met Met Lys Arg Gln Leu His Arg Met Arg Gln Leu Ala Gln Thr Gly 
1               5                   10                  15      


Ser Leu Gly Arg Thr Pro Glu Thr Ala Glu Phe Leu Gly Glu Asp Leu 
            20                  25                  30          


Leu Gln Val Glu Gln Arg Leu Glu Pro Ala Lys Arg Ala Ala His Asn 
        35                  40                  45              


Ile His Lys Arg Leu Gln Ala Cys Leu Gln Gly Gln Ser Gly Ala Asp 
    50                  55                  60                  


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
65                  70                  75                  80  


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
                85                  90                  95      


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
            100                 105                 110         


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
        115                 120                 125             


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
    130                 135                 140                 


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
145                 150                 155                 160 


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
                165                 170                 175     


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
            180                 185                 190         


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
        195                 200                 205             


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
    210                 215                 220                 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
225                 230                 235                 240 


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
                245                 250                 255     


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
            260                 265                 270         


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
        275                 280                 285             


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
    290                 295                 300                 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
305                 310                 315                 320 


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
                325                 330                 335     


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
            340                 345                 350         


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
        355                 360                 365             


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
    370                 375                 380                 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
385                 390                 395                 400 


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
                405                 410                 415     


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
            420                 425                 430         


Trp Pro Pro Glu Lys Glu Gly Thr Glu Pro Ala Arg Glu Leu Gly Ser 
        435                 440                 445             


Gln Thr Leu Cys 
    450         


<210> 5648
<211> 378
<212> PRT
<213> Homo sapiens

<400> 5648
Met Asn Asn Ser Gly Ala Asp Glu Ile Gly Lys Leu Phe Val Gly Gly 
1               5                   10                  15      


Leu Asp Trp Ser Thr Thr Gln Glu Thr Leu Arg Ser Tyr Phe Ser Gln 
            20                  25                  30          


Tyr Gly Glu Val Val Asp Cys Val Ile Met Lys Asp Lys Thr Thr Asn 
        35                  40                  45              


Gln Ser Arg Gly Phe Gly Phe Val Lys Phe Lys Asp Pro Asn Cys Val 
    50                  55                  60                  


Gly Thr Val Leu Ala Ser Arg Pro His Thr Leu Asp Gly Arg Asn Ile 
65                  70                  75                  80  


Asp Pro Lys Pro Cys Thr Pro Arg Gly Met Gln Pro Glu Arg Thr Arg 
                85                  90                  95      


Pro Lys Glu Gly Trp Gln Lys Gly Pro Arg Ser Asp Asn Ser Lys Ser 
            100                 105                 110         


Asn Lys Ile Phe Val Gly Gly Ile Pro His Asn Cys Gly Glu Thr Glu 
        115                 120                 125             


Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val Val Met 
    130                 135                 140                 


Ile Tyr Asp Ala Glu Lys Gln Arg Pro Arg Gly Phe Gly Phe Ile Thr 
145                 150                 155                 160 


Phe Glu Asp Glu Gln Ser Val Asp Gln Ala Val Asn Met His Phe His 
                165                 170                 175     


Asp Ile Met Gly Lys Lys Val Glu Val Lys Arg Ala Glu Pro Arg Asp 
            180                 185                 190         


Ser Lys Ser Gln Ala Pro Gly Gln Pro Gly Ala Ser Gln Trp Gly Ser 
        195                 200                 205             


Arg Val Val Pro Asn Ala Ala Asn Gly Trp Ala Gly Gln Pro Pro Pro 
    210                 215                 220                 


Thr Trp Gln Gln Gly Tyr Gly Pro Gln Gly Met Trp Val Pro Ala Gly 
225                 230                 235                 240 


Gln Ala Ile Gly Gly Tyr Gly Pro Pro Pro Ala Gly Arg Gly Ala Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Phe Thr Ser Tyr Ile Val Ser Thr Pro Pro Gly 
            260                 265                 270         


Gly Phe Pro Pro Pro Gln Gly Phe Pro Gln Gly Tyr Gly Ala Pro Pro 
        275                 280                 285             


Gln Phe Ser Phe Gly Tyr Gly Pro Pro Pro Pro Pro Pro Asp Gln Phe 
    290                 295                 300                 


Ala Pro Pro Gly Val Pro Pro Pro Pro Ala Thr Pro Gly Ala Ala Pro 
305                 310                 315                 320 


Leu Ala Phe Pro Pro Pro Pro Ser Gln Ala Ala Pro Asp Met Ser Lys 
                325                 330                 335     


Pro Pro Thr Ala Gln Pro Asp Phe Pro Tyr Gly Gln Tyr Gly Leu Gly 
            340                 345                 350         


Ser Tyr Ser Pro Ala Pro Pro Gly Cys Gly Pro His Phe Val Tyr Ser 
        355                 360                 365             


Leu Met Val Arg Leu Ser Ser Asp Val Ala 
    370                 375             


<210> 5649
<211> 809
<212> PRT
<213> Homo sapiens

<400> 5649
Met Glu Val Leu Arg Glu Lys Val Glu Glu Glu Glu Glu Ala Glu Arg 
1               5                   10                  15      


Glu Glu Ala Ala Glu Trp Ala Glu Trp Ala Arg Met Glu Lys Met Met 
            20                  25                  30          


Arg Pro Val Glu Val Arg Lys Glu Glu Ile Thr Leu Lys Gln Glu Thr 
        35                  40                  45              


Leu Arg Asp Leu Glu Lys Lys Leu Ser Glu Ile Gln Ile Thr Val Ser 
    50                  55                  60                  


Ala Glu Leu Pro Ala Phe Thr Lys Asp Thr Ile Asp Ile Ser Lys Leu 
65                  70                  75                  80  


Pro Ile Ser Tyr Lys Thr Asn Thr Pro Lys Glu Glu His Leu Leu Gln 
                85                  90                  95      


Val Ala Asp Asn Phe Ser Arg Gln Tyr Ser His Leu Cys Pro Asp Arg 
            100                 105                 110         


Val Pro Leu Phe Leu His Pro Leu Asn Glu Cys Glu Val Pro Lys Phe 
        115                 120                 125             


Val Ser Thr Thr Leu Arg Pro Thr Leu Met Pro Tyr Pro Glu Leu Tyr 
    130                 135                 140                 


Asn Trp Asp Ser Cys Ala Gln Phe Val Ser Asp Phe Leu Thr Met Val 
145                 150                 155                 160 


Pro Leu Pro Asp Pro Leu Lys Pro Thr Ile Lys Lys Glu Glu Lys Val 
                165                 170                 175     


Leu Pro Lys Lys Tyr Thr Ile Lys Pro Pro Arg Asp Leu Cys Ser Arg 
            180                 185                 190         


Phe Glu Gln Glu Gln Glu Val Lys Lys Gln Gln Glu Ile Arg Ala Gln 
        195                 200                 205             


Glu Lys Lys Arg Leu Arg Glu Glu Glu Glu Arg Leu Met Glu Ala Glu 
    210                 215                 220                 


Lys Ala Lys Pro Asp Ala Leu His Gly Leu Arg Val His Ser Trp Val 
225                 230                 235                 240 


Leu Val Leu Ser Gly Lys Arg Glu Val Pro Glu Asn Phe Phe Ile Asp 
                245                 250                 255     


Pro Phe Thr Gly His Ser Tyr Ser Thr Gln Asp Glu His Phe Leu Gly 
            260                 265                 270         


Ile Glu Ser Leu Trp Asn His Lys Asn Tyr Trp Ile Asn Met Gln Asp 
        275                 280                 285             


Cys Trp Asn Cys Cys Lys Asp Leu Ile Phe Asp Leu Gly Asp Pro Val 
    290                 295                 300                 


Arg Trp Glu Tyr Met Leu Leu Gly Thr Asp Lys Ser Gln Leu Ser Leu 
305                 310                 315                 320 


Thr Glu Glu Asp Asp Ser Gly Ile Asn Asp Glu Asp Asp Val Glu Asn 
                325                 330                 335     


Leu Gly Lys Glu Asp Glu Asp Lys Ser Phe Asp Met Pro His Ser Trp 
            340                 345                 350         


Val Glu Gln Ile Glu Ile Ser Pro Glu Ala Phe Glu Thr Arg Cys Pro 
        355                 360                 365             


Asn Gly Lys Lys Val Ile Gln Tyr Lys Arg Ala Lys Leu Glu Lys Trp 
    370                 375                 380                 


Ala Pro Tyr Leu Asn Ser Asn Gly Leu Val Ser Arg Leu Thr Thr Tyr 
385                 390                 395                 400 


Glu Asp Leu Gln Cys Thr Asn Ile Leu Glu Ile Lys Glu Trp Tyr Gln 
                405                 410                 415     


Asn Arg Glu Asp Met Leu Glu Leu Lys His Ile Asn Lys Thr Thr Asp 
            420                 425                 430         


Leu Lys Thr Asp Tyr Phe Lys Pro Gly His Pro Gln Ala Leu Arg Val 
        435                 440                 445             


His Ser Tyr Lys Ser Met Gln Pro Glu Met Asp Arg Val Ile Glu Phe 
    450                 455                 460                 


Tyr Glu Thr Ala Arg Val Asp Gly Leu Met Lys Arg Glu Glu Thr Pro 
465                 470                 475                 480 


Arg Thr Met Thr Glu Tyr Tyr Gln Gly Arg Pro Asp Phe Leu Ser Tyr 
                485                 490                 495     


Arg His Ala Ser Phe Gly Pro Arg Val Lys Lys Leu Thr Leu Ser Ser 
            500                 505                 510         


Ala Glu Ser Asn Pro Arg Pro Ile Val Lys Ile Thr Glu Arg Phe Phe 
        515                 520                 525             


Arg Asn Pro Ala Lys Pro Ala Glu Glu Asp Val Ala Glu Arg Val Phe 
    530                 535                 540                 


Leu Val Ala Glu Glu Arg Ile Gln Leu Arg Tyr His Cys Arg Glu Asp 
545                 550                 555                 560 


His Ile Thr Ala Ser Lys Arg Glu Phe Leu Arg Arg Thr Glu Val Asp 
                565                 570                 575     


Ser Lys Gly Asn Lys Ile Ile Met Thr Pro Asp Met Cys Ile Ser Phe 
            580                 585                 590         


Glu Val Glu Pro Met Glu His Thr Lys Lys Leu Leu Tyr Gln Tyr Glu 
        595                 600                 605             


Ala Met Met His Leu Lys Arg Glu Glu Lys Leu Ser Arg His Gln Val 
    610                 615                 620                 


Trp Glu Ser Glu Leu Glu Val Leu Glu Ile Leu Lys Leu Arg Glu Glu 
625                 630                 635                 640 


Glu Glu Ala Ala His Thr Leu Thr Ile Ser Ile Tyr Asp Thr Lys Arg 
                645                 650                 655     


Asn Glu Lys Ser Lys Glu Tyr Arg Glu Ala Met Glu Arg Met Met His 
            660                 665                 670         


Glu Glu His Leu Arg Gln Val Glu Thr Gln Leu Asp Tyr Leu Ala Pro 
        675                 680                 685             


Phe Leu Ala Gln Leu Pro Pro Gly Glu Lys Leu Thr Cys Trp Gln Ala 
    690                 695                 700                 


Val Arg Leu Lys Asp Glu Cys Leu Ser Asp Phe Lys Gln Arg Leu Ile 
705                 710                 715                 720 


Asn Lys Ala Asn Leu Ile Gln Ala Arg Phe Glu Lys Glu Thr Gln Glu 
                725                 730                 735     


Leu Gln Lys Lys Gln Gln Trp Tyr Gln Glu Asn Gln Val Thr Leu Thr 
            740                 745                 750         


Pro Glu Asp Glu Asp Leu Tyr Leu Ser Tyr Cys Ser Gln Ala Met Phe 
        755                 760                 765             


Arg Ile Arg Ile Leu Glu Gln Arg Leu Asn Arg His Lys Glu Leu Ala 
    770                 775                 780                 


Pro Leu Lys Tyr Leu Ala Leu Glu Glu Lys Leu Tyr Lys Asp Pro Arg 
785                 790                 795                 800 


Leu Gly Glu Leu Gln Lys Ile Phe Ala 
                805                 


<210> 5650
<211> 275
<212> PRT
<213> Homo sapiens

<400> 5650
Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Glu 
            180                 185                 190         


Ala Arg His Ala Ala Ala Val Arg Val Leu Gln Val Gln Pro Arg Gly 
        195                 200                 205             


Ala Pro Leu Arg Leu Gly Arg Arg Val His Ser Pro Gly Ala Arg Gly 
    210                 215                 220                 


Arg Gly Ala Arg Ile Val Leu Val Arg Gly Gly Tyr Arg His Pro Gln 
225                 230                 235                 240 


Cys Pro Glu Thr Gln Ser Val Ala Ala Ala Pro Gly Ala Gly Phe Ser 
                245                 250                 255     


Pro Gly Pro Gly Leu His His Arg Pro Ser Ser Met Gly Arg Ser Leu 
            260                 265                 270         


Gly Ser Trp 
        275 


<210> 5651
<211> 218
<212> PRT
<213> Homo sapiens

<400> 5651
Met Asn Cys Arg Ser Glu Val Leu Glu Val Ser Val Glu Gly Arg Gln 
1               5                   10                  15      


Val Glu Glu Ala Met Leu Ala Val Leu His Thr Val Leu Leu His Arg 
            20                  25                  30          


Ser Thr Gly Lys Phe His Tyr Lys Lys Glu Gly Thr Tyr Ser Ile Gly 
        35                  40                  45              


Thr Val Gly Thr Gln Asp Val Asp Cys Asp Phe Ile Asp Phe Thr Tyr 
    50                  55                  60                  


Val Arg Val Ser Ser Glu Glu Leu Asp Arg Ala Leu Arg Lys Val Val 
65                  70                  75                  80  


Gly Glu Phe Lys Asp Ala Leu Arg Asn Ser Gly Gly Asp Gly Leu Gly 
                85                  90                  95      


Gln Met Ser Leu Glu Phe Tyr Gln Lys Lys Lys Ser Arg Trp Pro Phe 
            100                 105                 110         


Ser Asp Glu Cys Ile Pro Trp Glu Val Trp Thr Val Lys Val His Val 
        115                 120                 125             


Val Ala Leu Ala Thr Glu Gln Glu Arg Gln Ile Cys Arg Glu Lys Val 
    130                 135                 140                 


Gly Glu Lys Leu Cys Glu Lys Ile Ile Asn Ile Val Glu Val Met Asn 
145                 150                 155                 160 


Arg His Glu Tyr Leu Pro Lys Met Pro Thr Gln Ser Glu Val Asp Asn 
                165                 170                 175     


Val Phe Asp Thr Gly Leu Arg Asp Val Gln Pro Tyr Leu Tyr Lys Ile 
            180                 185                 190         


Ser Phe Gln Ile Thr Asp Ala Leu Gly Thr Ser Val Thr Thr Thr Met 
        195                 200                 205             


Arg Arg Leu Ile Lys Asp Thr Leu Ala Leu 
    210                 215             


<210> 5652
<211> 183
<212> PRT
<213> Homo sapiens

<400> 5652
Met Met Gln Ile Cys Asp Thr Tyr Asn Gln Lys His Ser Leu Phe Asn 
1               5                   10                  15      


Ala Met Asn Arg Phe Ile Gly Ala Val Asn Asn Met Asp Gln Thr Val 
            20                  25                  30          


Met Val Pro Ser Leu Leu Arg Asp Val Pro Leu Ala Asp Pro Gly Leu 
        35                  40                  45              


Asp Asn Asp Val Gly Val Glu Val Gly Gly Ser Gly Gly Cys Leu Glu 
    50                  55                  60                  


Glu Arg Thr Pro Pro Val Pro Asp Ser Gly Ser Ala Asn Gly Ser Phe 
65                  70                  75                  80  


Phe Ala Pro Ser Arg Asp Met Tyr Ser His Tyr Val Leu Leu Lys Ser 
                85                  90                  95      


Ile Arg Asn Asp Ile Glu Trp Gly Val Leu His Gln Pro Pro Pro Pro 
            100                 105                 110         


Ala Gly Ser Glu Glu Gly Ser Ala Trp Lys Ser Lys Asp Ile Leu Val 
        115                 120                 125             


Asp Leu Gly His Leu Glu Gly Ala Asp Ala Gly Glu Glu Asp Leu Glu 
    130                 135                 140                 


Gln Gln Phe His Tyr His Leu Arg Gly Leu His Thr Val Leu Ser Lys 
145                 150                 155                 160 


Leu Thr Arg Lys Ala Asn Ile Leu Thr Asn Arg Tyr Lys Gln Glu Ile 
                165                 170                 175     


Gly Phe Gly Asn Trp Gly His 
            180             


<210> 5653
<211> 122
<212> PRT
<213> Homo sapiens

<400> 5653
Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
1               5                   10                  15      


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
            20                  25                  30          


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
        35                  40                  45              


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
    50                  55                  60                  


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
65                  70                  75                  80  


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
                85                  90                  95      


Cys Ala Asn Cys Gly Gln Glu Gly Ser Asp Cys Arg Cys Thr Gly Ala 
            100                 105                 110         


Glu Arg Gly Ala Ile Leu Pro Ala Met Pro 
        115                 120         


<210> 5654
<211> 360
<212> PRT
<213> Homo sapiens

<400> 5654
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val 
    50                  55                  60                  


Leu Asn Val Glu Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln 
65                  70                  75                  80  


Leu Gln Arg Glu Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu 
                85                  90                  95      


Glu Lys Leu Asp Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr 
            100                 105                 110         


Gln Lys Thr Ala Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys 
        115                 120                 125             


Glu Glu Glu His Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Leu 
    130                 135                 140                 


Gln Thr Gly Leu Glu Ile Ser Lys Ile Ile Met Ser Ser Val Ser Asn 
145                 150                 155                 160 


Leu Lys His Ser Lys Glu Lys Lys Lys Ser Ser Lys Lys Thr Lys Cys 
                165                 170                 175     


Ile Lys Arg Arg Pro Pro Trp Gln Ile Cys Ser Lys Phe Gly Ala Leu 
            180                 185                 190         


Pro Phe Val Ala Glu Lys Pro Ser Arg Thr Thr Ser Trp Cys Lys Ala 
        195                 200                 205             


Ile Pro Pro Asp Ser Glu Lys Ser Ile Ser Ile Cys Asp Asn Leu Ser 
    210                 215                 220                 


Glu Leu Leu Met Ala Met Gln Asp Glu Leu Asp Gln Met Ser Met Glu 
225                 230                 235                 240 


His Gln Glu Leu Leu Lys Gln Met Lys Glu Thr Glu Ser His Ser Val 
                245                 250                 255     


Cys Asp Asp Ile Glu Cys Glu Leu Glu Cys Leu Leu Lys Lys Met Glu 
            260                 265                 270         


Ile Lys Gly Glu Gln Ile Ser Lys Leu Lys Lys His Gln Asp Ser Val 
        275                 280                 285             


Cys Lys Leu Gln Gln Lys Val Gln Asn Ser Lys Met Ser Glu Ala Ser 
    290                 295                 300                 


Gly Ile Gln Gln Glu Asp Ser Tyr Pro Lys Gly Ser Lys Asn Ile Lys 
305                 310                 315                 320 


Asn Ser Pro Arg Lys Cys Leu Thr Asp Thr Asn Leu Phe Gln Lys Asn 
                325                 330                 335     


Ser Ser Phe His Pro Ile Arg Val His Asn Leu Gln Met Lys Leu Arg 
            340                 345                 350         


Arg Asp Asp Ile Met Trp Glu Gln 
        355                 360 


<210> 5655
<211> 585
<212> PRT
<213> Homo sapiens

<400> 5655
Met Ser Gly Ser Thr Pro Phe Gln Met Arg Leu Val His Leu Asp Leu 
1               5                   10                  15      


Lys Gly Ala Pro Pro Lys Val Ser Tyr Leu Ser Glu Ile Phe Pro Leu 
            20                  25                  30          


Phe Arg Ala Leu Gly Ala Asn Gly Leu Leu Ile Glu Tyr Glu Asp Met 
        35                  40                  45              


Phe Pro Tyr Glu Gly Pro Leu Arg Leu Leu Arg Ala Lys Tyr Ala Tyr 
    50                  55                  60                  


Ser Pro Ser Glu Ile Lys Glu Ile Leu His Leu Ala Gly Leu Asn Glu 
65                  70                  75                  80  


Leu Glu Val Ile Pro Leu Val Gln Thr Phe Gly His Met Glu Phe Val 
                85                  90                  95      


Leu Lys His Thr Ala Phe Ala His Leu Arg Glu Val Gly Ser Phe Pro 
            100                 105                 110         


Cys Thr Leu Asn Pro His Glu Ala Glu Ser Leu Ala Leu Val Gly Ala 
        115                 120                 125             


Met Ile Asp Gln Val Leu Glu Leu His Pro Gly Ala Gln Arg Leu His 
    130                 135                 140                 


Ile Gly Cys Asp Glu Val Tyr Tyr Leu Gly Glu Gly Glu Ala Ser Arg 
145                 150                 155                 160 


Arg Trp Leu Gln Gln Glu Gln Asn Ser Thr Gly Lys Leu Cys Leu Ser 
                165                 170                 175     


His Met Arg Ala Val Ala Ser Gly Val Lys Ala Arg Arg Pro Ser Val 
            180                 185                 190         


Thr Pro Leu Val Trp Asp Asp Met Leu Arg Asp Leu Pro Glu Asp Gln 
        195                 200                 205             


Leu Ala Ala Ser Gly Val Pro Gln Leu Val Glu Pro Val Leu Trp Asp 
    210                 215                 220                 


Tyr Thr Ala Asp Leu Asp Val His Gly Lys Val Leu Leu Met Gln Lys 
225                 230                 235                 240 


Tyr Arg Arg Cys Gly Phe Pro Gln Leu Trp Ala Ala Ser Ala Phe Lys 
                245                 250                 255     


Gly Ala Thr Gly Pro Ser Gln Ala Val Pro Pro Val Glu His His Leu 
            260                 265                 270         


Arg Asn His Val Gln Trp Leu Gln Val Ala Gly Ser Gly Pro Thr Asp 
        275                 280                 285             


Ser Leu Gln Gly Ile Ile Leu Thr Gly Trp Gln Arg Tyr Asp His Tyr 
    290                 295                 300                 


Ser Val Leu Cys Glu Leu Leu Pro Ala Gly Val Pro Ser Leu Ala Ala 
305                 310                 315                 320 


Cys Leu Gln Leu Leu Leu Arg Gly Gly Phe Asp Glu Asp Val Lys Ala 
                325                 330                 335     


Lys Val Glu Asn Leu Leu Gly Ile Ser Ser Leu Glu Lys Thr Asp Pro 
            340                 345                 350         


Val Arg Gln Ala Pro Cys Ser Pro Pro Cys Pro Leu Leu Pro Leu Pro 
        355                 360                 365             


Phe Pro Arg Pro Trp Arg Gln Leu Phe Ser Ala Gly Leu Ser Ala Gly 
    370                 375                 380                 


Arg Gly Pro Ala Pro Ser Leu Ala Ala Thr Ser Leu Pro Leu Ser His 
385                 390                 395                 400 


Lys Ser Ala Ser Ile Cys Ala Ala Leu Trp Met Arg Cys Trp Arg Ala 
                405                 410                 415     


Thr Gly Met Ser Leu Ala Gly Ser Ala Pro Thr Thr Ala Ser Gly Ser 
            420                 425                 430         


Ser Ser Thr Arg Ser Trp Phe Ser Thr Ser Ser Pro Gln Arg Ser Ala 
        435                 440                 445             


Ser Trp His Ser Gly Ala Pro Ser Cys Arg Ser Trp Arg Leu Pro Cys 
    450                 455                 460                 


Ser Trp Leu Ser Thr Arg Met Pro Trp Arg Ser Gly Trp Arg Lys Thr 
465                 470                 475                 480 


Cys Thr Pro Ala Cys Ser Gly Cys Lys Leu Cys Cys Arg Thr Ser Ala 
                485                 490                 495     


Arg Cys Leu Pro Pro Arg Cys His Pro Pro Ala Leu Ala Gly Thr Leu 
            500                 505                 510         


Leu Arg Thr Pro Glu Gly Arg Ala His Ala Arg Gly Leu Leu Leu Glu 
        515                 520                 525             


Ala Gly Gly Ala Leu His Cys Gln Met Ala Trp Ala Ile Arg Ala His 
    530                 535                 540                 


Val Gly Val Val Pro Ser Gly Pro Ala Val Ser Cys Pro His Ser Val 
545                 550                 555                 560 


Pro Glu Gly Pro Gly Gln Pro Leu Gly Glu Arg Leu Glu Asn Thr Glu 
                565                 570                 575     


Gly Ser Ser Thr Gly Arg Pro Ala Leu 
            580                 585 


<210> 5656
<211> 703
<212> PRT
<213> Homo sapiens

<400> 5656
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Thr Met Arg Val Asn Asp Leu Val Gly Thr 
225                 230                 235                 240 


Ser Met Thr Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Thr Asn Thr Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Arg Pro Arg Glu Glu Ser Leu Ala Glu Lys Lys 
305                 310                 315                 320 


Tyr Thr Ser Gln Gly Gln Gly Asp Leu Asp Ser Val Leu Ser Gln Leu 
                325                 330                 335     


Asn Phe Thr His Thr Ser Glu Asp Leu Leu Gln Ala Glu Val Thr Cys 
            340                 345                 350         


Leu Glu Gly Ser Leu Glu Ser Val Ser Ala Thr Cys Lys Gln Leu Ser 
        355                 360                 365             


Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu Ala His 
    370                 375                 380                 


Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln Ile Leu 
385                 390                 395                 400 


Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys Met Glu 
                405                 410                 415     


Ile Ser His Leu Thr Gln Glu Leu His Gln Arg Asp Ile Thr Ile Ala 
            420                 425                 430         


Ser Thr Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg Ala Glu 
        435                 440                 445             


Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile Leu Asp 
    450                 455                 460                 


Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu Met Val 
465                 470                 475                 480 


Met Lys Leu Glu Leu Gly Leu His Glu Ala Lys Glu Ile Ser Leu Ala 
                485                 490                 495     


Asp Leu Gln Glu Asn Tyr Ile Glu Ala Leu Asn Lys Leu Val Ser Glu 
            500                 505                 510         


Asn Gln Gln Leu Gln Lys Asp Leu Met Asn Thr Lys Ser Gln Leu Glu 
        515                 520                 525             


Ile Ser Thr Gln Met Cys Lys Lys Gln Asn Asp Arg Ile Phe Lys Pro 
    530                 535                 540                 


Thr His Ser Arg Thr Thr Glu Phe Lys Asn Thr Glu Phe Lys Pro Thr 
545                 550                 555                 560 


His Gly Gln His Arg His Asp Gly Ile Lys Thr Glu His Tyr Lys Thr 
                565                 570                 575     


Asp Leu His Ser Pro Arg Gly Gln Ala Ser Asp Ser Ile Asn Pro Met 
            580                 585                 590         


Ser Arg Val Leu Ser Pro Leu Ser Pro Gln Ile Ser Pro Cys Ser Ser 
        595                 600                 605             


Thr Arg Ser Leu Thr Ser Tyr Ser Leu Cys Lys Thr His Ser Leu Pro 
    610                 615                 620                 


Ser Ala Leu Asp Thr Asn Glu Ala Asn Phe Ser Asp Thr Met Ser Glu 
625                 630                 635                 640 


Ser Met Asn Asp Gln Glu Glu Phe Ile Ser Ser Cys Ser Leu Pro Val 
                645                 650                 655     


Ser Pro Leu Gly Ser Ile Ala Thr Arg Phe Leu Glu Glu Glu Glu Leu 
            660                 665                 670         


Arg Ser His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu 
        675                 680                 685             


Lys Arg Glu Ser Glu Lys Thr Val Arg Gln Phe Thr Ala Leu Lys 
    690                 695                 700             


<210> 5657
<211> 541
<212> PRT
<213> Homo sapiens

<400> 5657
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Gln Gly Ser Glu Asp Asn Leu Gln Gly 
        515                 520                 525             


Thr Asp Pro Pro Pro Val Gly Glu Glu Glu Val Leu Leu 
    530                 535                 540     


<210> 5658
<211> 820
<212> PRT
<213> Homo sapiens

<400> 5658
Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val 
            20                  25                  30          


Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys 
                85                  90                  95      


Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Asp Ile Thr Gln Asp 
            100                 105                 110         


Leu Val Asp Glu Ser Glu Glu Glu Arg Phe Asp Asp Met Ser Ser Pro 
        115                 120                 125             


Gly Leu Glu Leu Pro Ser Cys Glu Leu Ser Arg Leu Glu Glu Ile Ala 
    130                 135                 140                 


Glu Leu Val Ala Ser Ser Leu Pro Ser Pro Leu Arg Arg Glu Lys Leu 
145                 150                 155                 160 


Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu Glu Leu 
                165                 170                 175     


Phe His Val Cys Glu Asp Leu Glu Asn Ile Glu Gly Leu His His Leu 
            180                 185                 190         


Tyr Glu Ile Ile Lys Gly Ile Phe Leu Leu Asn Arg Thr Ala Leu Phe 
        195                 200                 205             


Glu Val Met Phe Ser Glu Glu Cys Ile Met Asp Val Ile Gly Cys Leu 
    210                 215                 220                 


Glu Tyr Asp Pro Ala Leu Ser Gln Pro Arg Lys His Arg Glu Phe Leu 
225                 230                 235                 240 


Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Ser Asp Pro Glu 
                245                 250                 255     


Leu Lys Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile Gln Asp 
            260                 265                 270         


Met Val Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Met Leu Ser Thr 
        275                 280                 285             


Leu His Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Gly Met Leu 
    290                 295                 300                 


Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr Asp 
305                 310                 315                 320 


Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Val Asn Phe Leu Lys 
                325                 330                 335     


Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg Asp Ala 
            340                 345                 350         


Phe Phe Lys Thr Leu Ser Asn Met Gly Ile Leu Pro Ala Leu Glu Val 
        355                 360                 365             


Ile Leu Gly Met Asp Asp Thr Gln Val Arg Ser Ala Ala Thr Asp Ile 
    370                 375                 380                 


Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met Val Arg Glu Phe Val 
385                 390                 395                 400 


Met Gln Glu Ala Gln Gln Asn Asp Asp Asp Ile Leu Leu Ile Asn Leu 
                405                 410                 415     


Ile Ile Glu His Met Ile Cys Asp Thr Asp Pro Glu Leu Gly Gly Ala 
            420                 425                 430         


Val Gln Leu Met Gly Leu Leu Arg Thr Leu Val Asp Pro Glu Asn Met 
        435                 440                 445             


Leu Ala Thr Ala Asn Lys Thr Glu Lys Thr Glu Phe Leu Gly Phe Phe 
    450                 455                 460                 


Tyr Lys His Cys Met His Val Leu Thr Ala Pro Leu Leu Ala Asn Thr 
465                 470                 475                 480 


Thr Glu Asp Lys Pro Ser Lys Asp Asp Phe Gln Thr Ala Gln Leu Leu 
                485                 490                 495     


Ala Leu Val Leu Glu Leu Leu Thr Phe Cys Val Glu His His Thr Tyr 
            500                 505                 510         


His Ile Lys Asn Tyr Ile Ile Asn Lys Asp Ile Leu Arg Arg Val Leu 
        515                 520                 525             


Val Leu Met Ala Ser Lys His Ala Phe Leu Ala Leu Cys Ala Leu Arg 
    530                 535                 540                 


Phe Lys Arg Lys Ile Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr 
545                 550                 555                 560 


Ile Met Lys Ser Phe Leu Phe Glu Pro Val Val Lys Ala Phe Leu Asn 
                565                 570                 575     


Asn Gly Ser Arg Tyr Asn Leu Met Asn Ser Ala Ile Ile Glu Met Phe 
            580                 585                 590         


Glu Phe Ile Arg Val Glu Asp Ile Lys Ser Leu Thr Ala His Val Ile 
        595                 600                 605             


Glu Asn Tyr Trp Lys Ala Leu Glu Asp Val Asp Tyr Val Gln Thr Phe 
    610                 615                 620                 


Lys Gly Leu Lys Leu Arg Phe Glu Gln Gln Arg Glu Arg Gln Asp Asn 
625                 630                 635                 640 


Pro Lys Leu Asp Ser Met Arg Ser Ile Leu Arg Asn His Arg Tyr Arg 
                645                 650                 655     


Arg Asp Ala Arg Thr Leu Glu Asp Glu Glu Glu Met Trp Phe Asn Thr 
            660                 665                 670         


Asp Glu Asp Asp Met Glu Asp Gly Glu Ala Val Val Ser Pro Ser Asp 
        675                 680                 685             


Lys Thr Lys Asn Asp Asp Asp Ile Met Asp Pro Ile Ser Lys Phe Met 
    690                 695                 700                 


Glu Arg Lys Lys Leu Lys Glu Ser Glu Glu Lys Glu Val Leu Leu Lys 
705                 710                 715                 720 


Thr Asn Leu Ser Gly Arg Gln Ser Pro Ser Phe Lys Leu Ser Leu Ser 
                725                 730                 735     


Ser Gly Thr Lys Thr Asn Leu Thr Ser Gln Ser Ser Thr Thr Asn Leu 
            740                 745                 750         


Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro 
        755                 760                 765             


Gly Ser Val Pro Lys Asn Thr Ser Gln Thr Ala Ala Ile Thr Thr Lys 
    770                 775                 780                 


Gly Gly Leu Val Gly Leu Val Asp Tyr Pro Asp Asp Asp Glu Asp Asp 
785                 790                 795                 800 


Asp Glu Asp Glu Asp Lys Glu Asp Thr Leu Pro Leu Ser Lys Lys Ala 
                805                 810                 815     


Lys Phe Asp Ser 
            820 


<210> 5659
<211> 793
<212> PRT
<213> Homo sapiens

<400> 5659
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Glu Ser Ile His Leu Gln Leu Ser Ser 
                85                  90                  95      


Phe Ser Ser Leu Gln Glu Glu Asp Lys Ser Arg Lys Asp Asp Ser Glu 
            100                 105                 110         


Arg Glu Lys Glu Lys Asp Lys Asn Lys Asp Lys Thr Ser Glu Lys Pro 
        115                 120                 125             


Lys Ile Arg Met Leu Ser Lys Asp Cys Ser Gln Glu Tyr Thr Asp Ser 
    130                 135                 140                 


Thr Gly Ile Asp Leu His Glu Phe Leu Ile Asn Thr Leu Lys Asn Asn 
145                 150                 155                 160 


Ser Arg Asp Arg Met Ile Leu Leu Lys Met Glu Gln Glu Ile Ile Asp 
                165                 170                 175     


Phe Ile Ala Asp Asn Asn Asn His Tyr Lys Lys Phe Pro Gln Met Ser 
            180                 185                 190         


Ser Tyr Gln Arg Met Leu Val His Arg Val Ala Ala Tyr Phe Gly Leu 
        195                 200                 205             


Asp His Asn Val Asp Gln Thr Gly Lys Ser Val Ile Ile Asn Lys Thr 
    210                 215                 220                 


Ser Ser Thr Arg Ile Pro Glu Gln Arg Phe Cys Glu His Leu Lys Asp 
225                 230                 235                 240 


Glu Lys Gly Glu Glu Ser Gln Lys Arg Phe Ile Leu Lys Arg Asp Asn 
                245                 250                 255     


Ser Ser Ile Asp Lys Glu Asp Asn Gln Ser Val Cys Ser Gln Glu Ser 
            260                 265                 270         


Leu Phe Val Glu Asn Arg Gly Asn Arg Asp Gly Ser Gly Arg Thr Ser 
        275                 280                 285             


Gly Ser Arg Gln Ser Ser Ser Glu Asn Glu Leu Lys Trp Ser Asp His 
    290                 295                 300                 


Gln Arg Ala Trp Ser Ser Thr Asp Ser Asp Ser Ser Asn Arg Asn Leu 
305                 310                 315                 320 


Lys Pro Ala Met Thr Lys Thr Ala Ser Phe Gly Gly Ile Thr Val Leu 
                325                 330                 335     


Thr Arg Gly Asp Ser Thr Ser Ser Thr Arg Ser Thr Gly Lys Leu Ser 
            340                 345                 350         


Lys Ala Gly Ser Glu Ser Ser Ser Ser Ala Gly Ser Ser Gly Ser Leu 
        355                 360                 365             


Ser Arg Thr His Pro Pro Leu Gln Ser Thr Pro Leu Val Ser Gly Val 
    370                 375                 380                 


Ala Ala Gly Ser Pro Gly Cys Val Pro Tyr Pro Glu Asn Gly Ile Gly 
385                 390                 395                 400 


Gly Gln Val Ala Pro Ser Ser Thr Ser Tyr Ile Leu Leu Pro Leu Glu 
                405                 410                 415     


Ala Ala Thr Gly Ile Pro Pro Gly Ser Ile Leu Leu Asn Pro His Thr 
            420                 425                 430         


Gly Gln Pro Phe Val Asn Pro Asp Gly Thr Pro Ala Ile Tyr Asn Pro 
        435                 440                 445             


Pro Thr Ser Gln Gln Pro Leu Arg Ser Ala Met Val Gly Gln Ser Gln 
    450                 455                 460                 


Gln Gln Pro Pro Gln Gln Gln Pro Ser Pro Gln Pro Gln Gln Gln Val 
465                 470                 475                 480 


Gln Pro Pro Gln Pro Gln Met Ala Gly Pro Leu Val Thr Gln Ser Val 
                485                 490                 495     


Gln Gly Leu Gln Ala Ser Ser Gln Ser Val Gln Tyr Pro Ala Val Ser 
            500                 505                 510         


Phe Pro Pro Gln His Leu Leu Pro Val Ser Pro Thr Gln His Phe Pro 
        515                 520                 525             


Met Arg Asp Asp Val Ala Thr Gln Phe Gly Gln Met Thr Leu Ser Arg 
    530                 535                 540                 


Gln Ser Ser Gly Glu Thr Pro Glu Pro Pro Ser Gly Pro Val Tyr Pro 
545                 550                 555                 560 


Ser Ser Leu Met Pro Gln Pro Ala Gln Gln Pro Ser Tyr Val Ile Ala 
                565                 570                 575     


Ser Thr Gly Gln Gln Leu Pro Thr Gly Gly Phe Ser Gly Ser Gly Pro 
            580                 585                 590         


Pro Ile Ser Gln Gln Val Leu Gln Pro Pro Pro Ser Pro Gln Gly Phe 
        595                 600                 605             


Val Gln Gln Pro Pro Pro Ala Gln Met Pro Val Tyr Tyr Tyr Pro Ser 
    610                 615                 620                 


Gly Gln Tyr Pro Thr Ser Thr Thr Gln Gln Tyr Arg Pro Met Ala Pro 
625                 630                 635                 640 


Val Gln Tyr Asn Ala Gln Arg Ser Gln Gln Met Pro Gln Ala Ala Gln 
                645                 650                 655     


Gln Ala Gly Tyr Gln Pro Val Leu Ser Gly Gln Gln Gly Phe Gln Gly 
            660                 665                 670         


Leu Ile Gly Val Gln Gln Pro Pro Gln Ser Gln Asn Val Ile Asn Asn 
        675                 680                 685             


Gln Gln Gly Thr Pro Val Gln Ser Val Met Val Ser Tyr Pro Thr Met 
    690                 695                 700                 


Ser Ser Tyr Gln Val Pro Met Thr Gln Gly Ser Gln Gly Leu Pro Gln 
705                 710                 715                 720 


Gln Ser Tyr Gln Gln Pro Ile Met Leu Pro Asn Gln Ala Gly Gln Gly 
                725                 730                 735     


Ser Leu Pro Ala Thr Gly Met Pro Val Tyr Cys Asn Val Thr Pro Pro 
            740                 745                 750         


Thr Pro Gln Asn Asn Leu Arg Leu Ile Gly Pro His Cys Pro Ser Ser 
        755                 760                 765             


Thr Val Pro Val Met Ser Ala Ser Cys Arg Thr Asn Cys Ala Ser Met 
    770                 775                 780                 


Ser Asn Ala Gly Trp Gln Val Lys Phe 
785                 790             


<210> 5660
<211> 488
<212> PRT
<213> Homo sapiens

<400> 5660
Met Arg Phe His Trp Leu Pro Thr Leu Ser Glu Pro Phe Asp Arg Asn 
1               5                   10                  15      


Gln Glu Leu Glu Thr Cys Ile Arg Pro Leu Trp Thr Pro Ser Gly Ser 
            20                  25                  30          


Ala Cys Glu Thr Glu His Asn Lys Ser Met Asp Met Gly Asn Gln His 
        35                  40                  45              


Pro Ser Ile Ser Arg Leu Gln Glu Ile Gln Lys Glu Val Lys Ser Val 
    50                  55                  60                  


Glu Gln Gln Val Ile Gly Phe Ser Gly Leu Ser Asp Asp Lys Asn Tyr 
65                  70                  75                  80  


Lys Lys Leu Glu Arg Ile Leu Thr Lys Gln Leu Phe Glu Ile Asp Ser 
                85                  90                  95      


Val Asp Thr Glu Gly Lys Gly Asp Ile Gln Gln Ala Arg Lys Arg Ala 
            100                 105                 110         


Ala Gln Glu Thr Glu Arg Leu Leu Lys Glu Leu Glu Gln Asn Ala Asn 
        115                 120                 125             


His Pro His Arg Ile Glu Ile Gln Asn Ile Phe Glu Glu Ala Gln Ser 
    130                 135                 140                 


Leu Val Arg Glu Lys Ile Val Pro Phe Tyr Asn Gly Gly Asn Cys Val 
145                 150                 155                 160 


Thr Asp Glu Phe Glu Glu Gly Ile Gln Asp Ile Ile Leu Arg Leu Thr 
                165                 170                 175     


His Val Lys Thr Gly Gly Lys Ile Ser Leu Arg Lys Ala Arg Tyr His 
            180                 185                 190         


Thr Leu Thr Lys Ile Cys Ala Val Gln Glu Ile Ile Glu Asp Cys Met 
        195                 200                 205             


Lys Lys Gln Pro Ser Leu Pro Leu Ser Glu Asp Ala His Pro Ser Val 
    210                 215                 220                 


Ala Lys Ile Asn Phe Val Met Cys Glu Val Asn Lys Ala Arg Gly Val 
225                 230                 235                 240 


Leu Ile Ala Leu Leu Met Gly Val Asn Asn Asn Glu Thr Cys Arg His 
                245                 250                 255     


Leu Ser Cys Val Leu Ser Gly Leu Ile Ala Asp Leu Asp Ala Leu Asp 
            260                 265                 270         


Val Cys Gly Arg Thr Glu Ile Arg Asn Tyr Arg Arg Glu Val Val Glu 
        275                 280                 285             


Asp Ile Asn Lys Leu Leu Lys Tyr Leu Asp Leu Glu Glu Glu Ala Asp 
    290                 295                 300                 


Thr Thr Lys Ala Phe Asp Leu Arg Gln Asn His Ser Ile Leu Lys Ile 
305                 310                 315                 320 


Glu Lys Val Leu Lys Arg Met Arg Glu Ile Lys Asn Glu Leu Leu Gln 
                325                 330                 335     


Ala Gln Asn Pro Ser Glu Leu Tyr Leu Ser Ser Lys Thr Glu Leu Gln 
            340                 345                 350         


Gly Leu Ile Gly Gln Leu Asp Glu Val Ser Leu Glu Lys Asn Pro Cys 
        355                 360                 365             


Ile Arg Glu Ala Arg Arg Arg Ala Val Ile Glu Val Gln Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Ile Asp Leu Lys Glu Ala Leu Glu Lys Arg Lys Leu Phe Ala 
385                 390                 395                 400 


Cys Glu Glu His Pro Ser His Lys Ala Val Trp Asn Val Leu Gly Asn 
                405                 410                 415     


Leu Ser Glu Ile Gln Gly Glu Val Leu Ser Phe Asp Gly Asn Arg Thr 
            420                 425                 430         


Asp Lys Asn Tyr Ile Arg Leu Glu Glu Leu Leu Thr Lys Gln Leu Leu 
        435                 440                 445             


Ala Leu Asp Ala Val Asp Pro Gln Gly Glu Glu Lys Cys Lys Ala Ala 
    450                 455                 460                 


Arg Lys Gln Ala Val Arg Leu Ala Gln Asn Ile Leu Ser Tyr Leu Asp 
465                 470                 475                 480 


Leu Lys Ser Asp Glu Trp Glu Tyr 
                485             


<210> 5661
<211> 325
<212> PRT
<213> Homo sapiens

<400> 5661
Met Gly Lys Met Val Ser Val Ile Asn Thr Val Asp Thr Ser His Glu 
1               5                   10                  15      


Asp Met Ile His Asp Ala Gln Met Asp Tyr Tyr Gly Thr Arg Leu Ala 
            20                  25                  30          


Thr Cys Ser Ser Asp Arg Ser Val Lys Ile Phe Asp Val Arg Asn Gly 
        35                  40                  45              


Gly Gln Ile Leu Ile Ala Asp Leu Arg Gly His Glu Gly Pro Val Trp 
    50                  55                  60                  


Gln Val Ala Trp Ala His Pro Met Tyr Gly Asn Ile Leu Ala Ser Cys 
65                  70                  75                  80  


Ser Tyr Asp Arg Lys Val Ile Ile Trp Arg Glu Glu Asn Gly Thr Trp 
                85                  90                  95      


Glu Lys Ser His Glu His Ala Gly His Asp Ser Ser Val Asn Ser Val 
            100                 105                 110         


Cys Trp Ala Pro His Asp Tyr Gly Leu Ile Leu Ala Cys Gly Ser Ser 
        115                 120                 125             


Asp Gly Ala Ile Ser Leu Leu Thr Tyr Thr Gly Glu Gly Gln Trp Glu 
    130                 135                 140                 


Val Lys Lys Ile Asn Asn Ala His Thr Ile Gly Cys Asn Ala Val Ser 
145                 150                 155                 160 


Trp Ala Pro Ala Val Val Pro Gly Ser Leu Ile Asp His Pro Ser Gly 
                165                 170                 175     


Gln Lys Pro Asn Tyr Ile Lys Arg Phe Ala Ser Gly Gly Cys Asp Asn 
            180                 185                 190         


Leu Ile Lys Leu Trp Lys Glu Glu Glu Asp Gly Gln Trp Lys Glu Glu 
        195                 200                 205             


Gln Lys Leu Glu Ala His Ser Asp Trp Val Arg Asp Val Ala Trp Ala 
    210                 215                 220                 


Pro Ser Ile Gly Leu Pro Thr Ser Thr Ile Ala Ser Cys Ser Gln Asp 
225                 230                 235                 240 


Gly Arg Val Phe Ile Trp Thr Cys Asp Asp Ala Ser Ser Asn Thr Trp 
                245                 250                 255     


Ser Pro Lys Leu Leu His Lys Phe Asn Asp Val Val Trp His Val Ser 
            260                 265                 270         


Trp Ser Ile Thr Ala Asn Ile Leu Ala Val Ser Gly Gly Asp Asn Lys 
        275                 280                 285             


Val Thr Leu Trp Lys Glu Ser Val Asp Gly Gln Trp Val Cys Ile Ser 
    290                 295                 300                 


Asp Val Asn Lys Gly Gln Gly Ser Val Ser Ala Ser Val Thr Glu Gly 
305                 310                 315                 320 


Gln Gln Asn Glu Gln 
                325 


<210> 5662
<211> 281
<212> PRT
<213> Homo sapiens

<400> 5662
Met Leu Phe Ile Phe Pro Leu Ser Leu Pro Trp Arg Pro Ser Cys Trp 
1               5                   10                  15      


Lys Glu Ser Cys Ser Thr Gly Gln Arg Gln Ala Gly Arg Ser Arg Glu 
            20                  25                  30          


Asp Ser Val Thr Pro Pro Pro Ser Ser Pro Trp Pro Thr Pro Pro Ala 
        35                  40                  45              


Gly Ala Met Ser Thr Lys Gln Glu Ala Arg Arg Asp Glu Gly Glu Ala 
    50                  55                  60                  


Arg Thr Arg Gly Gln Glu Ala Gln Leu Arg Asp Arg Ala His Leu Ser 
65                  70                  75                  80  


Gln Gln Arg Arg Leu Lys Gln Ala Thr Gln Phe Leu His Lys Asp Ser 
                85                  90                  95      


Ala Asp Leu Leu Pro Leu Asp Ser Leu Lys Arg Leu Gly Thr Ser Lys 
            100                 105                 110         


Asp Leu Gln Pro Arg Ser Val Ile Gln Arg Arg Leu Val Glu Gly Asn 
        115                 120                 125             


Pro Asn Trp Leu Gln Gly Glu Pro Pro Arg Met Gln Asp Leu Ile His 
    130                 135                 140                 


Gly Gln Glu Ser Arg Arg Lys Thr Ser Arg Thr Glu Ile Pro Ala Leu 
145                 150                 155                 160 


Leu Val Asn Cys Lys Cys Gln Asp Gln Leu Leu Arg Val Ala Val Asp 
                165                 170                 175     


Thr Gly Thr Gln Tyr Asn Arg Ile Ser Ala Gly Cys Leu Ser Arg Leu 
            180                 185                 190         


Gly Leu Glu Lys Arg Val Leu Lys Ala Ser Ala Gly Asp Leu Ala Pro 
        195                 200                 205             


Gly Pro Pro Thr Gln Val Glu Gln Leu Glu Leu Gln Leu Gly Gln Glu 
    210                 215                 220                 


Thr Val Val Cys Ser Ala Gln Val Val Asp Ala Glu Ser Pro Glu Phe 
225                 230                 235                 240 


Cys Leu Gly Leu Gln Thr Leu Leu Ser Leu Lys Cys Cys Ile Asp Leu 
                245                 250                 255     


Glu His Gly Val Leu Arg Leu Lys Ala Pro Phe Ser Glu Leu Pro Phe 
            260                 265                 270         


Leu Pro Leu Tyr Gln Glu Pro Gly Gln 
        275                 280     


<210> 5663
<211> 510
<212> PRT
<213> Homo sapiens

<400> 5663
Thr Gly Gly Gly Val Ala Pro Ala Gly Gln Val Arg Thr Ala Thr Trp 
1               5                   10                  15      


Ala Arg Arg Ala Arg Pro Tyr Arg Lys Met Ala Ala Arg Thr Gly Thr 
            20                  25                  30          


Glu Leu Ala Ser Ala Ala Ser Thr Thr Ala Pro Gly Ser Ser Lys Arg 
        35                  40                  45              


Arg Lys Arg His Pro Trp His Thr Val Ser Arg Arg Pro Gly Arg Thr 
    50                  55                  60                  


Pro Lys Trp Arg Leu Pro Arg Ile Ser Ala Arg Ala Pro Tyr Arg Leu 
65                  70                  75                  80  


Arg Arg Leu Arg Arg His Thr Tyr Trp Pro Pro Arg Arg Pro Val Ala 
                85                  90                  95      


Ala Ser Arg Cys Trp Pro Val Gly Ala Thr Pro Leu Gly Ser Val Gly 
            100                 105                 110         


Gly Arg Thr Gly Lys Met Asp Ala Ala Thr Leu Thr Tyr Asp Thr Leu 
        115                 120                 125             


Arg Phe Ala Glu Phe Glu Asp Phe Pro Glu Thr Ser Glu Pro Val Trp 
    130                 135                 140                 


Ile Leu Gly Arg Lys Tyr Ser Ile Phe Thr Glu Lys Asp Glu Ile Leu 
145                 150                 155                 160 


Ser Asp Val Ala Ser Arg Leu Trp Phe Thr Tyr Arg Lys Asn Phe Pro 
                165                 170                 175     


Ala Ile Gly Gly Thr Gly Pro Thr Ser Asp Thr Gly Trp Gly Cys Met 
            180                 185                 190         


Leu Arg Cys Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg His 
        195                 200                 205             


Leu Gly Arg Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp Ser 
    210                 215                 220                 


Tyr Phe Ser Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr Tyr 
225                 230                 235                 240 


Ser Ile His Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile 
                245                 250                 255     


Gly Gln Trp Tyr Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu 
            260                 265                 270         


Ala Val Phe Asp Thr Trp Ser Ser Leu Ala Val His Ile Ala Met Asp 
        275                 280                 285             


Asn Thr Val Val Met Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser Val 
    290                 295                 300                 


Pro Cys Ala Gly Ala Thr Ala Phe Pro Ala Asp Ser Asp Arg His Cys 
305                 310                 315                 320 


Asn Gly Phe Pro Ala Gly Ala Glu Val Thr Asn Arg Pro Ser Pro Trp 
                325                 330                 335     


Arg Pro Leu Val Leu Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp Ile 
            340                 345                 350         


Asn Glu Ala Tyr Val Glu Thr Leu Lys His Cys Phe Met Met Pro Gln 
        355                 360                 365             


Ser Leu Gly Val Ile Gly Gly Lys Pro Asn Ser Ala His Tyr Phe Ile 
    370                 375                 380                 


Gly Tyr Val Gly Glu Glu Leu Ile Tyr Leu Asp Pro His Thr Thr Gln 
385                 390                 395                 400 


Pro Ala Val Glu Pro Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser Phe 
                405                 410                 415     


His Cys Gln His Pro Pro Cys Arg Met Ser Ile Ala Glu Leu Asp Pro 
            420                 425                 430         


Ser Ile Ala Val Gly Phe Phe Cys Lys Thr Glu Asp Asp Phe Asn Asp 
        435                 440                 445             


Trp Cys Gln Gln Val Lys Lys Leu Ser Leu Leu Gly Gly Ala Leu Pro 
    450                 455                 460                 


Met Phe Glu Leu Val Glu Leu Gln Pro Ser His Leu Ala Cys Pro Asp 
465                 470                 475                 480 


Val Leu Asn Leu Ser Leu Asp Ser Ser Asp Val Glu Arg Leu Glu Arg 
                485                 490                 495     


Phe Phe Asp Ser Glu Asp Glu Asp Phe Glu Ile Leu Ser Leu 
            500                 505                 510 


<210> 5664
<211> 183
<212> PRT
<213> Homo sapiens

<400> 5664
Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210> 5665
<211> 487
<212> PRT
<213> Homo sapiens

<400> 5665
Met Glu Arg Ser Gly Gln Arg Val Thr Thr Trp Asp Cys Asp Gln Gly 
1               5                   10                  15      


Lys His Ser Asp Ser Asp Tyr Arg Glu Asp Gly Met Asp Leu Gly Ser 
            20                  25                  30          


Asp Ala Gly Ser Ser Ser Ser Ser Ser Arg Ala Ser Ser Gln Ser Asn 
        35                  40                  45              


Ser Thr Lys Val Thr Pro Cys Ser Glu Cys Lys Ser Ser Ser Ser Pro 
    50                  55                  60                  


Gly Gly Ser Leu Asp Leu Val Ser Ala Leu Glu Asp Tyr Glu Glu Pro 
65                  70                  75                  80  


Phe Pro Val Tyr Gln Lys Lys Val Ile Asp Glu Trp Ala Pro Glu Glu 
                85                  90                  95      


Asp Gly Glu Glu Glu Glu Glu Glu Asp Glu Arg Asp Gln Arg Gly Tyr 
            100                 105                 110         


Arg Asp Asp Arg Ser Pro Ala Arg Glu Pro Gly Asp Val Ser Ala Arg 
        115                 120                 125             


Thr Arg Ser Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Met Pro 
    130                 135                 140                 


Pro Pro Val Pro Asn Gly Asn Leu His Gln His Asp Pro Gln Asp Leu 
145                 150                 155                 160 


Arg His Asn Gly Asn Val Val Val Ala Gly Arg Pro Ser Cys Ser Arg 
                165                 170                 175     


Gly Pro Arg Arg Ala Ile Gln Lys Pro Gln Pro Ala Gly Gly Arg Arg 
            180                 185                 190         


Ser Gly Arg Gly Pro Ala Ala Gly Gly Leu Cys Leu Gln Pro Pro Asp 
        195                 200                 205             


Gly Gly Thr Cys Val Pro Glu Glu Pro Pro Val Pro Pro Met Asp Trp 
    210                 215                 220                 


Glu Ala Leu Glu Lys His Leu Ala Gly Leu Gln Phe Arg Glu Gln Glu 
225                 230                 235                 240 


Val Arg Asn Gln Gly Gln Ala Arg Thr Asn Ser Thr Ser Ala Gln Lys 
                245                 250                 255     


Asn Glu Arg Glu Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe Phe 
            260                 265                 270         


Asp Asp Gly Pro Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys Pro 
        275                 280                 285             


Ser Leu Ser Ser Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys Phe 
    290                 295                 300                 


Val Asn Asp Ser Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser Lys 
305                 310                 315                 320 


Thr Glu Thr Ser Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln Ser 
                325                 330                 335     


Ser Ser Tyr Ser Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser Leu 
            340                 345                 350         


Asp Asp Met Asp Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu Ala 
        355                 360                 365             


Lys Met Ala Leu Ala Met Ala Lys Pro Met Ala Lys Met Gln Val Glu 
    370                 375                 380                 


Val Glu Lys Gln Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu Pro 
385                 390                 395                 400 


His Met Pro His Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys Pro 
                405                 410                 415     


Thr Asp Leu Arg Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val Asn 
            420                 425                 430         


Asp Leu His Ser Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln Leu 
        435                 440                 445             


Leu Leu Ile Arg Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu Val 
    450                 455                 460                 


Asp Ile Glu Asp Leu Thr Arg His Ala Glu Ser Gln Gln Lys His Met 
465                 470                 475                 480 


Ala Glu Lys Met Pro Ala Lys 
                485         


<210> 5666
<211> 308
<212> PRT
<213> Homo sapiens

<400> 5666
Met Lys Arg Ala His Pro Glu Tyr Ser Ser Ser Asp Ser Glu Leu Asp 
1               5                   10                  15      


Glu Thr Ile Glu Val Glu Lys Glu Ser Ala Asp Glu Asn Gly Asn Leu 
            20                  25                  30          


Ser Ser Ala Leu Gly Ser Met Ser Pro Thr Thr Ser Ser Gln Ile Leu 
        35                  40                  45              


Ala Arg Lys Arg Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg 
    50                  55                  60                  


Ile Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Ser Ala Phe 
65                  70                  75                  80  


Glu Lys Gln Val Met Glu Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu 
                85                  90                  95      


Ile Leu Gln Met Thr Val Asp His Leu Lys Met Leu His Thr Ala Gly 
            100                 105                 110         


Gly Lys Gly Tyr Phe Asp Ala His Ala Leu Ala Met Asp Tyr Arg Ser 
        115                 120                 125             


Leu Gly Phe Arg Glu Cys Leu Ala Glu Val Ala Arg Tyr Leu Ser Ile 
    130                 135                 140                 


Ile Glu Gly Leu Asp Ala Ser Asp Pro Leu Arg Val Arg Leu Val Ser 
145                 150                 155                 160 


His Leu Asn Asn Tyr Ala Ser Gln Arg Glu Ala Ala Ser Gly Ala His 
                165                 170                 175     


Ala Gly Leu Gly His Ile Pro Trp Gly Thr Val Phe Gly His His Pro 
            180                 185                 190         


His Ile Ala His Pro Leu Leu Leu Pro Gln Asn Gly His Gly Asn Ala 
        195                 200                 205             


Gly Thr Thr Ala Ser Pro Thr Glu Pro His His Gln Gly Arg Leu Gly 
    210                 215                 220                 


Ser Ala His Pro Glu Ala Pro Ala Leu Arg Ala Pro Pro Ser Gly Ser 
225                 230                 235                 240 


Leu Gly Pro Val Leu Pro Val Val Thr Ser Ala Ser Lys Leu Ser Pro 
                245                 250                 255     


Pro Leu Leu Ser Ser Val Ala Ser Leu Ser Ala Phe Pro Phe Ser Phe 
            260                 265                 270         


Gly Ser Phe His Leu Leu Ser Pro Asn Ala Leu Ser Pro Ser Ala Pro 
        275                 280                 285             


Thr Gln Ala Ala Asn Leu Gly Lys Pro Tyr Arg Pro Trp Gly Thr Glu 
    290                 295                 300                 


Ile Gly Ala Phe 
305             


<210> 5667
<211> 445
<212> PRT
<213> Homo sapiens

<400> 5667
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 
145                 150                 155                 160 


Ala Ala Cys Lys Glu Glu Lys Leu Ala Ile Ser Arg Glu Ala Asn Ser 
                165                 170                 175     


Lys Ala Asp Pro Ser Leu Asn Pro Glu Gln Leu Lys Lys Leu Gln Asp 
            180                 185                 190         


Lys Ile Glu Lys Cys Lys Gln Asp Val Leu Lys Thr Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ser Leu Lys Glu Leu Asp Gln Gly Thr Pro Gln Tyr Met Glu 
    210                 215                 220                 


Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys Arg 
225                 230                 235                 240 


Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gln Lys His Leu Asp 
                245                 250                 255     


Leu Ser Asn Val Ala Gly Tyr Lys Ala Ile Tyr His Asp Leu Glu Gln 
            260                 265                 270         


Ser Ile Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala 
        275                 280                 285             


Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp 
    290                 295                 300                 


Ser Ala Asp Leu Asn Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 
305                 310                 315                 320 


Thr Asp Gly Val Thr Leu Thr Gly Ile Asn Gln Thr Gly Asp Gln Ser 
                325                 330                 335     


Leu Pro Ser Lys Pro Ser Ser Val Ser Ser Tyr Glu Lys Thr Gln Ser 
            340                 345                 350         


Tyr Pro Thr Asp Trp Ser Asp Asp Glu Ser Asn Asn Pro Phe Ser Ser 
        355                 360                 365             


Thr Asp Ala Asn Gly Asp Ser Asn Pro Phe Asp Asp Asp Ala Thr Ser 
    370                 375                 380                 


Gly Thr Glu Val Arg Val Arg Ala Leu Tyr Asp Tyr Glu Gly Gln Glu 
385                 390                 395                 400 


His Asp Glu Leu Ser Phe Lys Ala Gly Asp Glu Leu Thr Lys Met Glu 
                405                 410                 415     


Asp Glu Asp Glu Gln Gly Trp Cys Lys Gly Arg Leu Asp Asn Gly Gln 
            420                 425                 430         


Val Gly Leu Tyr Pro Ala Asn Tyr Val Glu Ala Ile Gln 
        435                 440                 445 


<210> 5668
<211> 415
<212> PRT
<213> Homo sapiens

<400> 5668
Met Met Leu Gly Pro Glu Gly Gly Glu Gly Phe Val Val Lys Leu Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Val Glu Asp Val Gln Asn Phe Leu Ser 
            20                  25                  30          


Asp Cys Thr Ile His Asp Gly Ala Ala Gly Val His Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Gln Ser Gly Glu Ala Phe Val Glu Leu Gly Ser Glu 
    50                  55                  60                  


Asp Asp Val Lys Met Ala Leu Lys Lys Asp Arg Glu Ser Met Gly His 
65                  70                  75                  80  


Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu Glu Val Arg 
            180                 185                 190         


Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly Ile Val Lys 
    210                 215                 220                 


Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser Thr Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr Gly Phe Thr 
                245                 250                 255     


Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser Gly Met Tyr 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr Gly Ala Ser 
        355                 360                 365             


Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly Val Ser Ala 
    370                 375                 380                 


Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val Ser Gly Cys 
385                 390                 395                 400 


Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly Tyr Asp 
                405                 410                 415 


<210> 5669
<211> 589
<212> PRT
<213> Homo sapiens

<400> 5669
Met Ser Val Ser Val His Glu Thr Arg Lys Ser Arg Ser Ser Thr Gly 
1               5                   10                  15      


Ser Met Asn Val Thr Leu Phe His Lys Ala Ser His Pro Asp Cys Val 
            20                  25                  30          


Leu Ala His Leu Asn Thr Leu Arg Lys His Cys Met Phe Thr Asp Val 
        35                  40                  45              


Thr Leu Trp Ala Gly Asp Arg Ala Phe Pro Cys His Arg Ala Val Leu 
    50                  55                  60                  


Ala Ala Ser Ser Arg Tyr Phe Glu Ala Met Phe Ser His Gly Leu Arg 
65                  70                  75                  80  


Glu Ser Arg Asp Asp Thr Val Asn Phe Gln Asp Asn Leu His Pro Glu 
                85                  90                  95      


Val Leu Glu Leu Leu Leu Asp Phe Ala Tyr Ser Ser Arg Ile Ala Ile 
            100                 105                 110         


Asn Glu Glu Asn Ala Glu Ser Leu Leu Glu Ala Gly Asp Met Leu Gln 
        115                 120                 125             


Phe His Asp Val Arg Asp Ala Ala Ala Glu Phe Leu Glu Lys Asn Leu 
    130                 135                 140                 


Phe Pro Ser Asn Cys Leu Gly Met Met Leu Leu Ser Asp Ala His Gln 
145                 150                 155                 160 


Cys Arg Arg Leu Tyr Glu Phe Ser Trp Arg Met Cys Leu Val His Phe 
                165                 170                 175     


Glu Thr Val Arg Gln Ser Glu Asp Phe Asn Ser Leu Ser Lys Asp Thr 
            180                 185                 190         


Leu Leu Asp Leu Ile Ser Ser Asp Glu Leu Glu Thr Glu Asp Glu Arg 
        195                 200                 205             


Val Val Phe Glu Ala Ile Leu Gln Trp Val Lys His Asp Leu Glu Pro 
    210                 215                 220                 


Arg Lys Val His Leu Pro Glu Leu Leu Arg Ser Val Arg Leu Ala Leu 
225                 230                 235                 240 


Leu Pro Ser Asp Cys Leu Gln Glu Ala Val Ser Ser Glu Ala Leu Leu 
                245                 250                 255     


Met Ala Asp Glu Arg Thr Lys Leu Ile Met Asp Glu Ala Leu Arg Cys 
            260                 265                 270         


Lys Thr Arg Ile Leu Gln Asn Asp Gly Val Val Thr Ser Pro Cys Ala 
        275                 280                 285             


Arg Pro Arg Lys Ala Gly His Thr Leu Leu Ile Leu Gly Gly Gln Thr 
    290                 295                 300                 


Phe Met Cys Asp Lys Ile Tyr Gln Val Asp His Lys Ala Lys Glu Ile 
305                 310                 315                 320 


Ile Pro Lys Ala Asp Leu Pro Ser Pro Arg Lys Glu Phe Ser Ala Ser 
                325                 330                 335     


Ala Ile Gly Cys Lys Val Tyr Val Thr Gly Gly Arg Gly Ser Glu Asn 
            340                 345                 350         


Gly Val Ser Lys Asp Val Trp Val Tyr Asp Thr Val His Glu Glu Trp 
        355                 360                 365             


Ser Lys Ala Ala Pro Met Leu Ile Ala Arg Phe Gly His Gly Ser Ala 
    370                 375                 380                 


Glu Leu Glu Asn Cys Leu Tyr Val Val Gly Gly His Thr Ser Leu Ala 
385                 390                 395                 400 


Gly Val Phe Pro Ala Ser Pro Ser Val Ser Leu Lys Gln Val Glu Lys 
                405                 410                 415     


Tyr Asp Pro Gly Ala Asn Lys Trp Met Met Val Ala Pro Leu Arg Asp 
            420                 425                 430         


Gly Val Ser Asn Ala Ala Val Val Ser Ala Lys Leu Lys Leu Phe Val 
        435                 440                 445             


Phe Gly Gly Thr Ser Ile His Arg Asp Met Val Ser Lys Val Gln Cys 
    450                 455                 460                 


Tyr Asp Pro Ser Glu Asn Arg Trp Thr Ile Lys Ala Glu Cys Pro Gln 
465                 470                 475                 480 


Pro Trp Arg Tyr Thr Ala Ala Ala Val Leu Gly Ser Gln Ile Phe Ile 
                485                 490                 495     


Met Gly Gly Asp Thr Glu Phe Thr Ala Ala Ser Ala Tyr Arg Phe Asp 
            500                 505                 510         


Cys Glu Thr Asn Gln Trp Thr Arg Ile Gly Asp Met Thr Ala Lys Arg 
        515                 520                 525             


Met Ser Cys His Ala Leu Ala Ser Gly Asn Lys Leu Tyr Val Val Gly 
    530                 535                 540                 


Gly Tyr Phe Gly Thr Gln Arg Cys Lys Thr Leu Asp Cys Tyr Asp Pro 
545                 550                 555                 560 


Thr Ser Asp Thr Trp Asn Cys Ile Thr Thr Val Pro Tyr Ser Leu Ile 
                565                 570                 575     


Pro Thr Ala Phe Val Ser Thr Trp Lys His Leu Pro Ala 
            580                 585                 


<210> 5670
<211> 436
<212> PRT
<213> Homo sapiens

<400> 5670
Met Met Gly Glu Ala Ala Val Ala Ala Gly Pro Cys Pro Leu Arg Glu 
1               5                   10                  15      


Asp Ser Phe Thr Arg Phe Ser Ser Gln Ser Asn Val Tyr Gly Leu Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Arg Gly Glu Leu Leu Ala Ala Thr Leu Lys Gly 
        35                  40                  45              


Lys Val Leu Gly Phe Arg Tyr Gln Asp Leu Arg Gln Lys Ile Arg Pro 
    50                  55                  60                  


Val Ala Lys Glu Leu Gln Phe Asn Tyr Ile Pro Val Asp Ala Glu Ile 
65                  70                  75                  80  


Val Ser Ile Asp Thr Phe Asn Lys Ser Pro Pro Lys Arg Gly Leu Val 
                85                  90                  95      


Val Gly Ile Thr Phe Ile Lys Asp Ser Gly Asp Lys Gly Ser Pro Phe 
            100                 105                 110         


Leu Asn Ile Tyr Cys Asp Tyr Glu Pro Gly Ser Glu Tyr Asn Leu Asp 
        115                 120                 125             


Ser Ile Ala Gln Ser Cys Leu Asn Leu Glu Leu Gln Phe Thr Pro Phe 
    130                 135                 140                 


Gln Leu Cys His Ala Glu Val Gln Val Gly Asp Gln Leu Glu Thr Val 
145                 150                 155                 160 


Phe Leu Leu Ser Gly Asn Asp Pro Ala Ile His Leu Tyr Lys Glu Asn 
                165                 170                 175     


Glu Gly Leu His Gln Phe Glu Glu Gln Pro Val Glu Asn Leu Phe Pro 
            180                 185                 190         


Glu Leu Thr Asn Leu Thr Ser Ser Val Leu Trp Leu Asp Val His Asn 
        195                 200                 205             


Phe Pro Gly Thr Ser Arg Arg Leu Ser Ala Leu Gly Cys Gln Ser Gly 
    210                 215                 220                 


Tyr Val Arg Val Ala His Val Asp Gln Arg Ser Arg Glu Val Leu Gln 
225                 230                 235                 240 


Met Trp Ser Val Leu Gln Asp Gly Pro Ile Ser Arg Val Ile Val Phe 
                245                 250                 255     


Ser Leu Ser Ala Ala Lys Glu Thr Lys Asp Arg Pro Leu Gln Asp Glu 
            260                 265                 270         


Tyr Ser Val Leu Val Ala Ser Met Leu Glu Pro Ala Val Val Tyr Arg 
        275                 280                 285             


Asp Leu Leu Asn Arg Gly Leu Glu Asp Gln Leu Leu Leu Pro Gly Ser 
    290                 295                 300                 


Asp Gln Phe Asp Ser Val Leu Cys Ser Leu Val Thr Asp Val Asp Leu 
305                 310                 315                 320 


Asp Gly Arg Pro Glu Val Leu Val Ala Thr Tyr Gly Gln Glu Leu Leu 
                325                 330                 335     


Cys Tyr Lys Tyr Arg Gly Pro Glu Ser Gly Leu Pro Glu Ala Gln His 
            340                 345                 350         


Gly Phe His Leu Leu Trp Gln Arg Ser Phe Ser Ser Pro Leu Leu Ala 
        355                 360                 365             


Met Ala His Val Asp Leu Thr Gly Asp Gly Leu Gln Glu Leu Ala Val 
    370                 375                 380                 


Val Ser Leu Lys Gly Val His Ile Leu Gln His Ser Leu Ile Gln Ala 
385                 390                 395                 400 


Ser Glu Leu Val Leu Thr Arg Leu Arg His Gln Val Glu Gln Arg Arg 
                405                 410                 415     


Arg Arg Leu Gln Gly Leu Glu Asp Gly Ala Gly Ala Gly Pro Ala Glu 
            420                 425                 430         


Asn Ala Ala Ser 
        435     


<210> 5671
<211> 213
<212> PRT
<213> Homo sapiens

<400> 5671
Met Leu Leu Pro Phe Ile Arg Thr Leu Pro Leu Leu Cys Tyr Asn His 
1               5                   10                  15      


Leu Leu Val Ser Pro Asp Ser Ala Thr Leu Ser Pro Pro Tyr Ser Leu 
            20                  25                  30          


Glu Lys Met Thr Asp Leu Val Ala Val Trp Asp Val Ala Leu Ser Asp 
        35                  40                  45              


Gly Val His Lys Ile Glu Phe Glu His Gly Thr Thr Ser Gly Lys Arg 
    50                  55                  60                  


Val Val Tyr Val Asp Gly Lys Glu Glu Ile Arg Lys Glu Trp Met Phe 
65                  70                  75                  80  


Lys Leu Val Gly Lys Glu Thr Phe Tyr Val Gly Ala Ala Lys Thr Lys 
                85                  90                  95      


Ala Thr Ile Asn Ile Asp Ala Ile Ser Gly Phe Ala Tyr Glu Tyr Thr 
            100                 105                 110         


Leu Glu Ile Asn Gly Lys Ser Leu Lys Lys Tyr Met Glu Asp Arg Ser 
        115                 120                 125             


Lys Thr Thr Asn Thr Trp Val Leu His Met Asp Gly Glu Asn Phe Arg 
    130                 135                 140                 


Ile Val Leu Glu Lys Asp Ala Met Asp Val Trp Cys Asn Gly Lys Lys 
145                 150                 155                 160 


Leu Glu Thr Ala Gly Glu Phe Val Asp Asp Gly Thr Glu Thr His Phe 
                165                 170                 175     


Ser Ile Gly Asn His Asp Cys Tyr Ile Lys Ala Val Ser Ser Gly Lys 
            180                 185                 190         


Arg Lys Glu Gly Ile Ile His Thr Leu Ile Val Asp Asn Arg Glu Ile 
        195                 200                 205             


Pro Glu Ile Ala Ser 
    210             


<210> 5672
<211> 220
<212> PRT
<213> Homo sapiens

<400> 5672
Met Thr Ser Gly Glu Val Lys Thr Ser Leu Lys Asn Ala Tyr Ser Ser 
1               5                   10                  15      


Ala Lys Arg Leu Ser Pro Lys Met Glu Glu Glu Gly Glu Glu Glu Asp 
            20                  25                  30          


Tyr Cys Thr Pro Gly Ala Phe Glu Leu Glu Arg Leu Phe Trp Lys Gly 
        35                  40                  45              


Ser Pro Gln Tyr Thr His Val Asn Glu Val Trp Pro Lys Leu Tyr Ile 
    50                  55                  60                  


Gly Asp Glu Ala Thr Ala Leu Asp Arg Tyr Arg Leu Gln Lys Ala Gly 
65                  70                  75                  80  


Phe Thr His Val Leu Asn Ala Ala His Gly Arg Trp Asn Val Asp Thr 
                85                  90                  95      


Gly Pro Asp Tyr Tyr Arg Asp Met Asp Ile Gln Tyr His Gly Val Glu 
            100                 105                 110         


Ala Asp Asp Leu Pro Thr Phe Asp Leu Ser Val Phe Phe Tyr Pro Ala 
        115                 120                 125             


Ala Ala Phe Ile Asp Arg Ala Leu Ser Asp Asp His Ser Lys Ile Leu 
    130                 135                 140                 


Val His Cys Val Met Gly Arg Ser Arg Ser Ala Thr Leu Val Leu Ala 
145                 150                 155                 160 


Tyr Leu Met Ile His Lys Asp Met Thr Leu Val Asp Ala Ile Gln Gln 
                165                 170                 175     


Val Ala Lys Asn Arg Cys Val Leu Pro Asn Arg Gly Phe Leu Lys Gln 
            180                 185                 190         


Leu Arg Glu Leu Asp Lys Gln Leu Val Gln Gln Arg Arg Arg Ser Gln 
        195                 200                 205             


Arg Gln Asp Gly Glu Glu Glu Asp Gly Arg Glu Leu 
    210                 215                 220 


<210> 5673
<211> 614
<212> PRT
<213> Homo sapiens

<400> 5673
Met Ser Pro Ala Asp Arg Cys Arg Ser Ala Asn Thr Ile Glu Pro Ala 
1               5                   10                  15      


Thr Thr Ser Ser Leu Ala Leu Phe Leu Leu Leu Gln Arg Asp Gln Ser 
            20                  25                  30          


Ser Arg Thr Arg Gly Leu Pro Glu Glu Lys Glu Glu Val Thr Met Asp 
        35                  40                  45              


Thr Ser Glu Asn Arg Pro Glu Asn Asp Val Pro Glu Pro Pro Met Pro 
    50                  55                  60                  


Ile Ala Asp Gln Val Ser Asn Asp Asp Arg Pro Glu Gly Ser Val Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Lys Glu Ser Ser Leu Pro Lys Ser Phe Lys Arg Lys 
                85                  90                  95      


Ile Ser Val Val Ser Ala Thr Lys Gly Val Pro Ala Gly Asn Ser Asp 
            100                 105                 110         


Thr Glu Gly Gly Gln Pro Gly Arg Lys Arg Arg Trp Gly Ala Ser Thr 
        115                 120                 125             


Ala Thr Thr Gln Lys Lys Pro Ser Ile Ser Ile Thr Thr Glu Ser Leu 
    130                 135                 140                 


Lys Ser Leu Ile Pro Asp Ile Lys Pro Leu Ala Gly Gln Glu Ala Val 
145                 150                 155                 160 


Val Asp Leu His Ala Asp Asp Ser Arg Ile Ser Glu Asp Glu Thr Glu 
                165                 170                 175     


Arg Asn Gly Asp Asp Gly Thr His Asp Lys Gly Leu Lys Ile Cys Arg 
            180                 185                 190         


Thr Val Thr Gln Val Val Pro Ala Glu Gly Gln Glu Asn Gly Gln Arg 
        195                 200                 205             


Glu Glu Glu Glu Glu Glu Lys Glu Pro Glu Ala Glu Pro Pro Val Pro 
    210                 215                 220                 


Pro Gln Val Ser Val Glu Val Ala Leu Pro Pro Pro Ala Glu His Glu 
225                 230                 235                 240 


Val Lys Lys Val Thr Leu Gly Asp Thr Leu Thr Arg Arg Ser Ile Ser 
                245                 250                 255     


Gln Gln Lys Ser Gly Val Ser Ile Thr Ile Asp Asp Pro Val Arg Thr 
            260                 265                 270         


Ala Gln Val Pro Ser Pro Pro Arg Gly Lys Ile Ser Asn Ile Val His 
        275                 280                 285             


Ile Ser Asn Leu Val Arg Pro Phe Thr Leu Gly Gln Leu Lys Glu Leu 
    290                 295                 300                 


Leu Gly Arg Thr Gly Thr Leu Val Glu Glu Ala Phe Trp Ile Asp Lys 
305                 310                 315                 320 


Ile Lys Ser His Cys Phe Val Thr Tyr Ser Thr Val Glu Glu Ala Val 
                325                 330                 335     


Ala Thr Arg Thr Ala Leu His Gly Val Lys Trp Pro Gln Ser Asn Pro 
            340                 345                 350         


Lys Phe Leu Cys Ala Asp Tyr Ala Glu Gln Asp Glu Leu Asp Tyr His 
        355                 360                 365             


Arg Gly Leu Leu Val Asp Arg Pro Ser Glu Thr Lys Thr Glu Glu Gln 
    370                 375                 380                 


Gly Ile Pro Arg Pro Leu His Pro Pro Pro Pro Pro Pro Val Gln Pro 
385                 390                 395                 400 


Pro Gln His Pro Arg Ala Glu Gln Arg Glu Gln Glu Arg Ala Val Arg 
                405                 410                 415     


Glu Gln Trp Ala Glu Arg Glu Arg Glu Met Glu Arg Arg Glu Arg Thr 
            420                 425                 430         


Arg Ser Glu Arg Glu Trp Asp Arg Asp Lys Val Arg Glu Gly Pro Arg 
        435                 440                 445             


Ser Arg Ser Arg Ser Arg Asp Arg Arg Arg Lys Glu Arg Ala Lys Ser 
    450                 455                 460                 


Lys Glu Lys Lys Ser Glu Lys Lys Glu Lys Ala Gln Glu Glu Pro Pro 
465                 470                 475                 480 


Ala Lys Leu Leu Asp Asp Leu Phe Arg Lys Thr Lys Ala Ala Pro Cys 
                485                 490                 495     


Ile Tyr Trp Leu Pro Leu Thr Asp Ser Gln Ile Val Gln Lys Glu Ala 
            500                 505                 510         


Glu Arg Ala Glu Arg Ala Lys Glu Arg Glu Lys Arg Arg Lys Glu Gln 
        515                 520                 525             


Glu Glu Glu Glu Gln Lys Glu Arg Glu Lys Glu Ala Glu Arg Glu Arg 
    530                 535                 540                 


Asn Arg Gln Leu Glu Arg Glu Lys Arg Arg Glu His Ser Arg Glu Arg 
545                 550                 555                 560 


Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg Gly Asp Arg Asp 
                565                 570                 575     


Arg Asp Arg Glu Arg Asp Arg Glu Arg Gly Arg Glu Arg Asp Arg Arg 
            580                 585                 590         


Asp Thr Lys Arg His Ser Arg Ser Arg Ser Arg Ser Thr Pro Val Arg 
        595                 600                 605             


Asp Arg Gly Gly Arg Arg 
    610                 


<210> 5674
<211> 400
<212> PRT
<213> Homo sapiens

<400> 5674
Met Lys Asn Glu Pro Leu Thr Pro Gly Tyr His Gly Phe Pro Ala Arg 
1               5                   10                  15      


Asp Ser Gln Gly Asn Gln Glu Pro Thr Thr Thr Pro Asp Ala Met Val 
            20                  25                  30          


Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro Pro Pro Gln Asn Gly Ile 
        35                  40                  45              


Pro Thr Glu Tyr Gly Val Pro His Thr Gln Asp Tyr Ala Gly Gln Thr 
    50                  55                  60                  


Gly Glu His Asn Leu Thr Leu Tyr Gly Ser Thr Gln Ala His Gly Glu 
65                  70                  75                  80  


Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn Gly Ser Leu Thr Thr Glu 
                85                  90                  95      


Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser Gln Thr Gln Ser Ser Glu 
            100                 105                 110         


Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg Leu His Val Ser Asn Ile 
        115                 120                 125             


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
    130                 135                 140                 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
145                 150                 155                 160 


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
                165                 170                 175     


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
            180                 185                 190         


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Met Val Thr Pro 
        195                 200                 205             


Tyr Ala Asn Gly Trp Lys Leu Ser Pro Val Val Gly Ala Val Tyr Gly 
    210                 215                 220                 


Pro Glu Leu Tyr Ala Ala Ser Ser Phe Gln Ala Asp Val Ser Leu Gly 
225                 230                 235                 240 


Asn Asp Ala Ala Val Pro Leu Ser Gly Arg Gly Gly Ile Asn Thr Tyr 
                245                 250                 255     


Ile Pro Leu Ile Ile Pro Gly Phe Pro Tyr Pro Thr Ala Ala Thr Thr 
            260                 265                 270         


Ala Ala Ala Phe Arg Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val 
        275                 280                 285             


Tyr Gly Ala Val Arg Ala Val Pro Pro Thr Ala Ile Pro Ala Tyr Pro 
    290                 295                 300                 


Gly Val Val Tyr Gln Asp Gly Phe Tyr Gly Ala Asp Leu Tyr Ile Glu 
305                 310                 315                 320 


Ser Ala Asn Cys Phe Arg Ser Asn Arg Val Asp Met Gln Pro Thr Asp 
                325                 330                 335     


Met His Ser Leu Leu Leu Gln Pro Gln Pro Pro Leu Leu Gln Pro Leu 
            340                 345                 350         


Gln Pro Leu Thr Val Thr Val Met Ala Gly Cys Thr Gln Pro Thr Pro 
        355                 360                 365             


Thr Met Pro Leu Pro Leu Pro Leu Ala Met Glu Leu Ala Leu Trp Arg 
    370                 375                 380                 


Val Tyr Thr Glu Val Ala Thr Ala Asp Leu Pro Pro Thr Glu Val Thr 
385                 390                 395                 400 


<210> 5675
<211> 514
<212> PRT
<213> Homo sapiens

<400> 5675
Met Asp Glu Gly Met Glu Ile Ser Ser Glu Gly Asn Ser Leu Ile Lys 
1               5                   10                  15      


Ala Val His Gln Ser Arg Leu Arg Leu Thr Arg Leu Leu Leu Glu Gly 
            20                  25                  30          


Gly Ala Tyr Ile Asn Glu Ser Asn Asp Arg Gly Glu Thr Pro Leu Met 
        35                  40                  45              


Ile Ala Cys Lys Thr Lys His Val Asp His Gln Ser Val Ser Lys Ala 
    50                  55                  60                  


Lys Met Val Lys Tyr Leu Leu Glu Asn Asn Ala Asp Pro Asn Ile Gln 
65                  70                  75                  80  


Asp Lys Ser Gly Lys Thr Ala Leu Met His Ala Cys Leu Glu Lys Ala 
                85                  90                  95      


Gly Pro Glu Val Val Ser Leu Leu Leu Lys Ser Gly Ala Asp Leu Ser 
            100                 105                 110         


Leu Gln Asp His Ser Ser Tyr Ser Ala Leu Val Tyr Ala Ile Asn Ser 
        115                 120                 125             


Glu Asp Thr Glu Thr Leu Lys Val Leu Leu Ser Ala Cys Lys Ala Lys 
    130                 135                 140                 


Gly Lys Glu Val Ile Ile Ile Thr Thr Ala Lys Leu Pro Cys Gly Lys 
145                 150                 155                 160 


His Thr Thr Lys Gln Tyr Leu Asn Met Pro Pro Val Asp Ile Asp Gly 
                165                 170                 175     


Cys His Ser Pro Ala Thr Cys Thr Thr Pro Ser Glu Ile Asp Ile Lys 
            180                 185                 190         


Thr Ala Ser Ser Pro Leu Ser His Ser Ser Glu Thr Glu Leu Thr Leu 
        195                 200                 205             


Phe Gly Phe Lys Asp Leu Glu Leu Ala Gly Ser Asn Asp Asp Thr Trp 
    210                 215                 220                 


Asp Pro Gly Ser Pro Val Arg Lys Pro Ala Leu Ala Pro Lys Gly Pro 
225                 230                 235                 240 


Lys Leu Pro His Ala Pro Pro Trp Val Lys Ser Pro Pro Leu Leu Met 
                245                 250                 255     


His Gln Asn Arg Val Ala Ser Leu Gln Glu Glu Leu Gln Asp Ile Thr 
            260                 265                 270         


Pro Glu Glu Glu Leu Ser Tyr Lys Thr Asn Gly Leu Ala Leu Ser Lys 
        275                 280                 285             


Arg Phe Ile Thr Arg His Gln Ser Ile Asp Val Lys Asp Thr Ala His 
    290                 295                 300                 


Leu Leu Arg Ala Phe Asp Gln Ala Ser Ser Arg Lys Met Ser Tyr Asp 
305                 310                 315                 320 


Glu Ile Asn Cys Gln Ser Tyr Leu Ser Glu Gly Asn Gln Gln Cys Ile 
                325                 330                 335     


Glu Val Pro Val Asp Gln Asp Pro Asp Ser Asn Gln Thr Ile Phe Ala 
            340                 345                 350         


Ser Thr Leu Arg Ser Ile Val Gln Lys Arg Asn Leu Gly Ala Asn His 
        355                 360                 365             


Tyr Ser Ser Asp Ser Gln Leu Ser Ala Gly Leu Thr Pro Pro Thr Ser 
    370                 375                 380                 


Glu Asp Gly Lys Ala Leu Ile Gly Lys Lys Lys Ile Leu Ser Pro Ser 
385                 390                 395                 400 


Pro Ser Gln Leu Ser Glu Ser Lys Glu Leu Leu Glu Asn Ile Pro Pro 
                405                 410                 415     


Gly Pro Leu Ser Arg Arg Asn His Ala Val Leu Glu Arg Arg Gly Ser 
            420                 425                 430         


Gly Ala Phe Pro Leu Asp His Ser Val Thr Gln Thr Arg Gln Gly Phe 
        435                 440                 445             


Leu Pro Pro Leu Asn Val Asn Ser His Pro Pro Ile Ser Asp Ile Asn 
    450                 455                 460                 


Val Asn Asn Lys Ile Cys Ser Leu Leu Ser Cys Gly Gln Lys Val Leu 
465                 470                 475                 480 


Met Pro Thr Val Pro Ile Phe Pro Lys Glu Phe Lys Ser Lys Lys Met 
                485                 490                 495     


Leu Leu Arg Arg Gln Ser Leu Gln Thr Glu Gln Ile Lys Gln Leu Val 
            500                 505                 510         


Asn Phe 
        


<210> 5676
<211> 557
<212> PRT
<213> Homo sapiens

<400> 5676
Met Asp Gln Ser Arg Val Leu Leu Trp Val Lys Ala Glu Pro Phe Ile 
1               5                   10                  15      


Val Gly Ala Leu Gln Val Pro Pro Pro Ser Lys Phe Ser Leu His Tyr 
            20                  25                  30          


Leu Arg Lys Ile Ser Thr Tyr Val Gln Ile Arg Ala Thr Glu Gly Ala 
        35                  40                  45              


Tyr Pro Arg Leu Tyr Trp Ser Thr Trp Arg His Ile Ala Cys Gly Lys 
    50                  55                  60                  


Leu Gln Leu Ala Lys Asp Leu Ala Trp Leu Tyr Phe Glu Ile Phe Asp 
65                  70                  75                  80  


Ser Leu Ser Met Lys Thr Pro Glu Glu Arg Leu Glu Trp Ser Glu Val 
                85                  90                  95      


Leu Ser Asn Cys Met Ser Glu Glu Glu Val Glu Lys Gln Arg Asn Gln 
            100                 105                 110         


Leu Ser Val Asp Thr Leu Gln Phe Leu Leu Phe Leu Tyr Ile Gln Gln 
        115                 120                 125             


Leu Asn Lys Val Ser Leu Arg Thr Ser Leu Ile Gly Glu Glu Trp Pro 
    130                 135                 140                 


Ser Pro Arg Asn Lys Ser Gln Ser Pro Asp Leu Thr Glu Lys Ser Asn 
145                 150                 155                 160 


Cys His Asn Lys Asn Trp Asn Asp Tyr Ser His Gln Ala Phe Val Tyr 
                165                 170                 175     


Asp His Leu Ser Asp Leu Leu Glu Leu Leu Leu Asp Pro Lys Gln Leu 
            180                 185                 190         


Thr Ala Ser Phe His Ser Thr His Ser Ser Leu Val Ser Arg Glu Ala 
        195                 200                 205             


Val Val Ala Leu Ser Phe Leu Ile Glu Gly Thr Ile Ser Arg Ala Arg 
    210                 215                 220                 


Lys Ile Tyr Pro Leu His Glu Leu Ala Leu Trp Gln Pro Leu His Ala 
225                 230                 235                 240 


Asp Ser Gly Phe Ser Lys Ile Ser Lys Thr Phe Ser Phe Tyr Lys Leu 
                245                 250                 255     


Glu Thr Trp Leu Arg Ser Cys Leu Thr Gly Asn Pro Phe Gly Thr Ser 
            260                 265                 270         


Ala Cys Leu Lys Ser Gly Lys Lys Leu Ala Trp Ala His Gln Val Glu 
        275                 280                 285             


Gly Thr Thr Lys Arg Ala Lys Ile Ala Cys Asn Thr His Val Ala Pro 
    290                 295                 300                 


Arg Met His Arg Leu Val Val Met Ser Gln Val Tyr Lys Gln Thr Leu 
305                 310                 315                 320 


Ala Lys Ser Ser Asp Thr Leu Ala Gly Ala His Val Lys Ile His Arg 
                325                 330                 335     


Cys Asn Glu Ser Phe Ile Tyr Leu Leu Ser Pro Leu Arg Ser Val Thr 
            340                 345                 350         


Ile Glu Lys Cys Arg Asn Ser Ile Phe Val Leu Gly Pro Val Gly Thr 
        355                 360                 365             


Thr Leu His Leu His Ser Cys Asp Asn Val Lys Val Ile Ala Val Cys 
    370                 375                 380                 


His Arg Leu Ser Ile Ser Ser Thr Thr Gly Cys Ile Phe His Val Leu 
385                 390                 395                 400 


Thr Pro Thr Arg Pro Leu Ile Leu Ser Gly Asn Gln Thr Val Thr Phe 
                405                 410                 415     


Ala Pro Phe His Thr His Tyr Pro Met Leu Glu Asp His Met Ala Arg 
            420                 425                 430         


Thr Gly Leu Ala Thr Val Pro Asn Tyr Trp Asp Asn Pro Met Val Val 
        435                 440                 445             


Cys Arg Glu Asn Ser Asp Thr Arg Val Phe Gln Leu Leu Pro Pro Cys 
    450                 455                 460                 


Glu Phe Tyr Val Phe Ile Ile Pro Phe Glu Met Glu Gly Asp Thr Thr 
465                 470                 475                 480 


Glu Ile Pro Gly Gly Leu Pro Ser Val Tyr Gln Lys Ala Leu Gly Gln 
                485                 490                 495     


Arg Glu Gln Lys Ile Gln Ile Trp Gln Lys Thr Val Lys Glu Ala His 
            500                 505                 510         


Leu Thr Lys Asp Gln Arg Lys Gln Phe Gln Val Leu Val Glu Asn Lys 
        515                 520                 525             


Phe Tyr Glu Trp Leu Ile Asn Thr Gly His Arg Gln Gln Leu Asp Ser 
    530                 535                 540                 


Leu Val Pro Pro Ala Ala Gly Ser Lys Gln Ala Ala Gly 
545                 550                 555         


<210> 5677
<211> 215
<212> PRT
<213> Homo sapiens

<400> 5677
Met Val Phe Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser 
1               5                   10                  15      


Phe Gly Pro His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp 
            20                  25                  30          


Gln Asn Arg Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln 
        35                  40                  45              


Ala Met Pro Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe 
    50                  55                  60                  


Pro His Ser Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala 
65                  70                  75                  80  


Asp Ile Asn Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu 
                85                  90                  95      


Ala Arg Glu Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val 
            100                 105                 110         


Met Lys Ala Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Glu Val Lys 
        115                 120                 125             


Lys Leu Gln Lys Ala Ala Leu Leu Lys Ala Ser Pro Lys Lys Ala Pro 
    130                 135                 140                 


Gly Thr Lys Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Val Pro Ala Lys Lys Ile Thr Ala Ala Ser Lys Lys Ala Pro Ala Gln 
                165                 170                 175     


Lys Val Pro Ala Gln Lys Ala Thr Gly Gln Lys Ala Ala Pro Ala Pro 
            180                 185                 190         


Lys Ala Gln Lys Gly Gln Lys Ala Pro Ala Gln Lys Ala Pro Ala Pro 
        195                 200                 205             


Lys Ala Ser Gly Lys Lys Ala 
    210                 215 


<210> 5678
<211> 295
<212> PRT
<213> Homo sapiens

<400> 5678
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 5679
<211> 455
<212> PRT
<213> Homo sapiens

<400> 5679
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala 
                325                 330                 335     


Arg Met Ser Glu Glu Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn 
            340                 345                 350         


Ser Ala Glu Met Ser Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly 
        355                 360                 365             


His Gly Met Asn Pro Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Phe Ser Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met 
385                 390                 395                 400 


Gln Ile Asn Met Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys 
                405                 410                 415     


Arg Arg Gly Lys Lys Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp 
            420                 425                 430         


Leu Ser Glu Gly Asp Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp 
        435                 440                 445             


Asn Asp Met Asp Asn Ser Glu 
    450                 455 


<210> 5680
<211> 140
<212> PRT
<213> Homo sapiens

<400> 5680
Met Arg Phe Arg Phe Cys Gly Asp Leu Asp Cys Pro Asp Trp Val Leu 
1               5                   10                  15      


Ala Glu Ile Ser Thr Leu Ala Lys Met Ser Ser Val Lys Leu Arg Leu 
            20                  25                  30          


Leu Cys Ser Gln Val Leu Lys Glu Leu Leu Gly Gln Gly Ile Asp Tyr 
        35                  40                  45              


Glu Lys Ile Leu Lys Leu Thr Ala Asp Ala Lys Phe Glu Ser Gly Asp 
    50                  55                  60                  


Val Lys Ala Thr Val Ala Val Leu Ser Phe Ile Leu Ser Ser Ala Ala 
65                  70                  75                  80  


Lys His Ser Val Asp Gly Glu Ser Leu Ser Ser Glu Leu Gln Gln Leu 
                85                  90                  95      


Gly Leu Pro Lys Glu His Ala Ala Ser Leu Cys Arg Cys Tyr Glu Glu 
            100                 105                 110         


Lys Gln Ser Pro Leu Gln Lys His Leu Arg Val Cys Ser Leu Arg Lys 
        115                 120                 125             


Leu Lys Gln Ala Gln Thr Leu Met Ser Ser Leu Gly 
    130                 135                 140 


<210> 5681
<211> 190
<212> PRT
<213> Homo sapiens

<400> 5681
Met Thr Ala Ser Ala Ser Ser Phe Ser Ser Ser Gln Gly Val Gln Gln 
1               5                   10                  15      


Pro Ser Ile Tyr Ser Phe Ser Gln Ile Thr Arg Ser Leu Phe Leu Ser 
            20                  25                  30          


Asn Gly Val Ala Ala Asn Asp Lys Leu Leu Leu Ser Ser Asn Arg Ile 
        35                  40                  45              


Thr Ala Ile Val Asn Ala Ser Val Glu Val Val Asn Val Phe Phe Glu 
    50                  55                  60                  


Gly Ile Gln Tyr Ile Lys Val Pro Val Thr Asp Ala Arg Asp Ser Arg 
65                  70                  75                  80  


Leu Tyr Asp Phe Phe Asp Pro Ile Ala Asp Leu Ile His Thr Ile Asp 
                85                  90                  95      


Met Arg Gln Gly Arg Thr Leu Leu His Cys Met Ala Gly Val Ser Arg 
            100                 105                 110         


Ser Ala Ser Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ser Met Ser 
        115                 120                 125             


Leu Leu Asp Ala His Thr Trp Thr Lys Ser Arg Arg Pro Ile Ile Arg 
    130                 135                 140                 


Pro Asn Asn Gly Phe Trp Glu Gln Leu Ile Asn Tyr Glu Phe Lys Leu 
145                 150                 155                 160 


Phe Asn Asn Asn Thr Val Arg Met Ile Asn Ser Pro Val Gly Asn Ile 
                165                 170                 175     


Pro Asp Ile Tyr Glu Lys Asp Leu Arg Met Met Ile Ser Met 
            180                 185                 190 


<210> 5682
<211> 1191
<212> PRT
<213> Homo sapiens

<400> 5682
Met Leu Arg Lys Leu Thr Ile Glu Gln Ile Asn Asp Trp Phe Thr Ile 
1               5                   10                  15      


Gly Lys Thr Val Thr Asn Val Glu Leu Leu Gly Ala Pro Pro Ala Phe 
            20                  25                  30          


Pro Ala Gly Ala Ala Arg Glu Glu Val Gln Arg Gln Asp Val Ala Pro 
        35                  40                  45              


Gly Ala Gly Pro Ala Ala Gln Ala Pro Ala Leu Ala Gln Ala Pro Ala 
    50                  55                  60                  


Arg Pro Ala Ala Ala Phe Glu Arg Ser Leu Ser Gln Arg Ser Ser Glu 
65                  70                  75                  80  


Val Glu Tyr Ile Asn Lys Tyr Arg Gln Leu Glu Ala Gln Glu Leu Asp 
                85                  90                  95      


Val Cys Arg Ser Val Gln Pro Thr Ser Gly Pro Gly Pro Arg Pro Ser 
            100                 105                 110         


Leu Ala Lys Leu Ser Ser Val Thr Cys Ile Pro Gly Thr Thr Tyr Lys 
        115                 120                 125             


Tyr Pro Asp Leu Pro Ile Ser Arg Tyr Lys Glu Glu Val Val Ser Leu 
    130                 135                 140                 


Ile Glu Ser Asn Ser Val Val Ile Ile His Gly Ala Thr Gly Ser Gly 
145                 150                 155                 160 


Lys Ser Thr Gln Leu Pro Gln Tyr Ile Leu Asp His Tyr Val Gln Arg 
                165                 170                 175     


Ser Ala Tyr Cys Ser Ile Val Val Thr Gln Pro Arg Lys Ile Gly Ala 
            180                 185                 190         


Ser Ser Ile Ala Arg Trp Ile Ser Lys Glu Arg Ala Trp Thr Leu Gly 
        195                 200                 205             


Gly Val Val Gly Tyr Gln Val Gly Leu Glu Lys Ile Ala Thr Glu Asp 
    210                 215                 220                 


Thr Arg Leu Ile Tyr Met Thr Thr Gly Val Leu Leu Gln Lys Ile Val 
225                 230                 235                 240 


Ser Ala Lys Ser Leu Met Glu Phe Thr His Ile Ile Ile Asp Glu Val 
                245                 250                 255     


His Glu Arg Thr Glu Glu Met Asp Phe Leu Leu Leu Val Val Arg Lys 
            260                 265                 270         


Leu Leu Arg Thr Asn Ser Arg Phe Val Lys Val Val Leu Met Ser Ala 
        275                 280                 285             


Thr Ile Ser Cys Lys Glu Phe Ala Asp Tyr Phe Ala Val Pro Val Gln 
    290                 295                 300                 


Asn Lys Met Asn Pro Ala Tyr Ile Phe Glu Val Glu Gly Lys Pro His 
305                 310                 315                 320 


Ser Val Glu Glu Tyr Tyr Leu Asn Asp Leu Glu His Ile His His Ser 
                325                 330                 335     


Lys Leu Ser Pro His Leu Leu Glu Glu Pro Val Ile Thr Lys Asp Ile 
            340                 345                 350         


Tyr Glu Val Ala Val Ser Leu Ile Gln Met Phe Asp Asp Leu Asp Met 
        355                 360                 365             


Lys Glu Ser Gly Asn Lys Ala Trp Ser Gly Ala Gln Phe Val Leu Glu 
    370                 375                 380                 


Arg Ser Ser Val Leu Val Phe Leu Pro Gly Leu Gly Glu Ile Asn Tyr 
385                 390                 395                 400 


Met His Glu Leu Leu Thr Ser Leu Val His Lys Arg Leu Gln Val Tyr 
                405                 410                 415     


Pro Leu His Ser Ser Val Ala Leu Glu Glu Gln Asn Asn Val Phe Leu 
            420                 425                 430         


Ser Pro Val Pro Gly Tyr Arg Lys Ile Ile Leu Ser Thr Asn Ile Ala 
        435                 440                 445             


Glu Ser Ser Val Thr Val Pro Asp Val Lys Tyr Val Ile Asp Phe Cys 
    450                 455                 460                 


Leu Thr Arg Thr Leu Val Cys Asp Glu Asp Thr Asn Tyr Gln Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Trp Ala Ser Lys Thr Ser Cys Asn Gln Arg Lys Gly Arg 
                485                 490                 495     


Ala Gly Arg Val Ser Arg Gly Tyr Cys Tyr Arg Leu Val His Lys Asp 
            500                 505                 510         


Phe Trp Asp Asn Ser Ile Pro Asp His Val Val Pro Glu Met Leu Arg 
        515                 520                 525             


Cys Pro Leu Gly Ser Thr Ile Leu Lys Val Lys Leu Leu Asp Met Gly 
    530                 535                 540                 


Glu Pro Arg Ala Leu Leu Ala Thr Ala Leu Ser Pro Pro Gly Leu Ser 
545                 550                 555                 560 


Asp Ile Glu Arg Thr Ile Leu Leu Leu Lys Glu Val Gly Ala Leu Ala 
                565                 570                 575     


Val Ser Gly Gln Arg Glu Asp Glu Asn Pro His Asp Gly Glu Leu Thr 
            580                 585                 590         


Phe Leu Gly Arg Val Leu Ala Gln Leu Pro Val Asn Gln Gln Leu Gly 
        595                 600                 605             


Lys Leu Ile Val Leu Gly His Val Phe Gly Cys Leu Asp Glu Cys Leu 
    610                 615                 620                 


Ile Ile Ala Ala Ala Leu Ser Leu Lys Asn Phe Phe Ala Met Pro Phe 
625                 630                 635                 640 


Arg Gln His Leu Asp Gly Tyr Arg Asn Lys Val Asn Phe Ser Gly Ser 
                645                 650                 655     


Ser Lys Ser Asp Cys Ile Ala Leu Val Glu Ala Phe Lys Thr Trp Lys 
            660                 665                 670         


Ala Cys Arg Gln Thr Gly Glu Leu Arg Tyr Pro Lys Asp Glu Leu Asn 
        675                 680                 685             


Trp Gly Arg Leu Asn Tyr Ile Gln Ile Lys Arg Ile Arg Glu Val Ala 
    690                 695                 700                 


Glu Leu Tyr Glu Glu Leu Lys Thr Arg Ile Ser Gln Phe Asn Met His 
705                 710                 715                 720 


Val Asp Ser Arg Arg Pro Val Met Asp Gln Glu Tyr Ile Tyr Lys Gln 
                725                 730                 735     


Arg Phe Ile Leu Gln Val Val Leu Ala Gly Ala Phe Tyr Pro Asn Tyr 
            740                 745                 750         


Phe Thr Phe Gly Gln Pro Asp Glu Glu Met Ala Val Arg Glu Leu Ala 
        755                 760                 765             


Gly Lys Asp Pro Lys Thr Thr Val Val Leu Lys His Ile Pro Pro Tyr 
    770                 775                 780                 


Gly Phe Leu Tyr Tyr Lys Gln Leu Gln Ser Leu Phe Arg Gln Cys Gly 
785                 790                 795                 800 


Gln Val Lys Ser Ile Val Phe Asp Gly Ala Lys Ala Phe Val Glu Phe 
                805                 810                 815     


Ser Arg Asn Pro Thr Glu Arg Phe Lys Thr Leu Pro Ala Val Tyr Met 
            820                 825                 830         


Ala Ile Lys Met Ser Gln Leu Lys Val Ser Leu Glu Leu Ser Val His 
        835                 840                 845             


Ser Ala Glu Glu Ile Glu Gly Lys Val Gln Gly Met Asn Val Ser Lys 
    850                 855                 860                 


Leu Arg Asn Thr Arg Val Asn Val Asp Phe Gln Lys Gln Thr Val Asp 
865                 870                 875                 880 


Pro Met Gln Val Ser Phe Asn Thr Ser Asp Arg Ser Gln Thr Val Thr 
                885                 890                 895     


Asp Leu Leu Leu Thr Ile Asp Val Thr Glu Val Val Glu Val Gly His 
            900                 905                 910         


Phe Trp Gly Tyr Arg Ile Asp Glu Asn Asn Ser Glu Ile Leu Lys Lys 
        915                 920                 925             


Leu Thr Ala Glu Ile Asn Gln Leu Thr Leu Val Pro Leu Pro Thr His 
    930                 935                 940                 


Pro His Pro Asp Leu Val Cys Leu Ala Pro Phe Ala Asp Phe Asp Lys 
945                 950                 955                 960 


Gln Arg Tyr Phe Arg Ala Gln Val Leu Tyr Val Ser Gly Asn Ser Ala 
                965                 970                 975     


Glu Val Phe Phe Val Asp Tyr Gly Asn Lys Ser His Val Asp Leu His 
            980                 985                 990         


Leu Leu Met Glu Ile Pro Cys Gln  Phe Leu Glu Leu Pro  Phe Gln Ala 
        995                 1000                 1005             


Leu Glu  Phe Lys Ile Cys Lys  Met Arg Pro Ser Ala  Lys Ser Leu 
    1010                 1015                 1020             


Val Cys  Gly Lys His Trp Ser  Asp Gly Ala Ser Gln  Trp Phe Ala 
    1025                 1030                 1035             


Ser Leu  Val Ser Gly Cys Thr  Leu Leu Val Lys Val  Phe Ser Val 
    1040                 1045                 1050             


Val His  Ser Val Leu His Val  Asp Val Tyr Gln Tyr  Ser Gly Val 
    1055                 1060                 1065             


Gln Asp  Ala Ile Asn Ile Arg  Asp Val Leu Ile Gln  Gln Gly Tyr 
    1070                 1075                 1080             


Ala Glu  Leu Thr Glu Glu Ser  Tyr Glu Ser Lys Val  Asn Ile Leu 
    1085                 1090                 1095             


Arg Ala  Ala Ile Asn Lys Leu  Val Cys Asp Gly Pro  Asn Gly Cys 
    1100                 1105                 1110             


Lys Cys  Leu Gly Pro Glu Arg  Val Ala Gln Leu Gln  Asp Ile Ala 
    1115                 1120                 1125             


Arg Gln  Lys Leu Leu Gly Leu  Phe Cys Gln Ser Lys  Pro Arg Glu 
    1130                 1135                 1140             


Lys Ile  Val Pro Lys Trp His  Glu Lys Pro Tyr Glu  Trp Asn Gln 
    1145                 1150                 1155             


Val Asp  Pro Lys Leu Val Met  Glu Gln Ala Asp Arg  Glu Ser Ser 
    1160                 1165                 1170             


Arg Gly  Lys Asn Thr Phe Leu  Tyr Gln Leu His Lys  Leu Val Val 
    1175                 1180                 1185             


Leu Gly  Thr 
    1190     


<210> 5683
<211> 301
<212> PRT
<213> Homo sapiens

<400> 5683
Met Thr Arg His Gly Lys Asn Cys Thr Ala Gly Ala Val Tyr Thr Tyr 
1               5                   10                  15      


His Glu Lys Lys Lys Asp Thr Ala Ala Ser Gly Tyr Gly Thr Gln Asn 
            20                  25                  30          


Ile Arg Leu Ser Arg Asp Ala Val Lys Asp Phe Asp Cys Cys Cys Leu 
        35                  40                  45              


Ser Leu Gln Pro Cys His Asp Pro Val Val Thr Pro Asp Gly Tyr Leu 
    50                  55                  60                  


Tyr Glu Arg Glu Ala Ile Leu Glu Tyr Ile Leu His Gln Lys Lys Glu 
65                  70                  75                  80  


Ile Ala Arg Gln Met Lys Ala Tyr Glu Lys Gln Arg Gly Thr Arg Arg 
                85                  90                  95      


Glu Glu Gln Lys Glu Leu Gln Arg Ala Ala Ser Gln Asp His Val Arg 
            100                 105                 110         


Gly Phe Leu Glu Lys Glu Ser Ala Ile Val Ser Arg Pro Leu Asn Pro 
        115                 120                 125             


Phe Thr Ala Lys Ala Leu Ser Gly Thr Ser Pro Asp Asp Val Gln Pro 
    130                 135                 140                 


Gly Pro Ser Val Gly Pro Pro Ser Lys Asp Lys Asp Lys Val Leu Pro 
145                 150                 155                 160 


Ser Phe Trp Ile Pro Ser Leu Thr Pro Glu Ala Lys Ala Thr Lys Leu 
                165                 170                 175     


Glu Lys Pro Ser Arg Thr Val Thr Cys Pro Met Ser Gly Lys Pro Leu 
            180                 185                 190         


Arg Met Ser Asp Leu Thr Pro Val His Phe Thr Pro Leu Asp Ser Ser 
        195                 200                 205             


Val Asp Arg Val Gly Leu Ile Thr Arg Ser Glu Arg Tyr Val Cys Ala 
    210                 215                 220                 


Val Thr Arg Asp Ser Leu Ser Asn Ala Thr Pro Cys Ala Val Leu Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Val Val Thr Leu Glu Cys Val Glu Lys Leu Ile Arg 
                245                 250                 255     


Lys Asp Met Val Asp Pro Val Thr Gly Asp Lys Leu Thr Asp Arg Asp 
            260                 265                 270         


Ile Ile Val Leu Gln Arg Gly Gly Thr Gly Phe Ala Gly Ser Gly Val 
        275                 280                 285             


Lys Leu Gln Ala Glu Lys Ser Arg Pro Val Met Gln Ala 
    290                 295                 300     


<210> 5684
<211> 502
<212> PRT
<213> Homo sapiens

<400> 5684
Met Gln Ser Cys Glu Ser Ser Gly Asp Ser Ala Asp Asp Pro Leu Ser 
1               5                   10                  15      


Arg Gly Leu Arg Arg Arg Gly Gln Pro Arg Val Val Val Ile Gly Ala 
            20                  25                  30          


Gly Leu Ala Gly Leu Ala Ala Ala Lys Ala Leu Leu Glu Gln Gly Phe 
        35                  40                  45              


Thr Asp Val Thr Val Leu Glu Ala Ser Ser His Ile Gly Gly Arg Val 
    50                  55                  60                  


Gln Ser Val Lys Leu Gly His Ala Thr Phe Glu Leu Gly Ala Thr Trp 
65                  70                  75                  80  


Ile His Gly Ser His Gly Asn Pro Ile Tyr His Leu Ala Glu Ala Asn 
                85                  90                  95      


Gly Leu Leu Glu Glu Thr Thr Asp Gly Glu Arg Ser Val Gly Arg Ile 
            100                 105                 110         


Ser Leu Tyr Ser Lys Asn Gly Val Ala Cys Tyr Leu Thr Asn His Gly 
        115                 120                 125             


Arg Arg Ile Pro Lys Asp Val Val Glu Glu Phe Ser Asp Leu Tyr Asn 
    130                 135                 140                 


Glu Val Tyr Asn Leu Thr Gln Glu Phe Phe Arg His Asp Lys Pro Val 
145                 150                 155                 160 


Asn Ala Glu Ser Gln Asn Ser Val Gly Val Phe Thr Arg Glu Glu Val 
                165                 170                 175     


Arg Asn Arg Ile Arg Asn Asp Pro Asp Asp Pro Glu Ala Thr Lys Arg 
            180                 185                 190         


Leu Lys Leu Ala Met Ile Gln Gln Tyr Leu Lys Val Glu Ser Cys Glu 
        195                 200                 205             


Ser Ser Ser His Ser Met Asp Glu Val Ser Leu Ser Ala Phe Gly Glu 
    210                 215                 220                 


Trp Thr Glu Ile Pro Gly Ala His His Ile Ile Pro Ser Gly Phe Met 
225                 230                 235                 240 


Arg Val Val Glu Leu Leu Ala Glu Gly Ile Pro Ala His Val Ile Gln 
                245                 250                 255     


Leu Gly Lys Pro Val Arg Cys Ile His Trp Asp Gln Ala Ser Ala Arg 
            260                 265                 270         


Pro Arg Gly Pro Glu Ile Glu Pro Arg Gly Val Leu Lys Arg Gln Tyr 
        275                 280                 285             


Thr Ser Phe Phe Arg Pro Gly Leu Pro Thr Glu Lys Val Ala Ala Ile 
    290                 295                 300                 


His Arg Leu Gly Ile Gly Thr Thr Asp Lys Ile Phe Leu Glu Phe Glu 
305                 310                 315                 320 


Glu Pro Phe Trp Gly Pro Glu Cys Asn Ser Leu Gln Phe Val Trp Glu 
                325                 330                 335     


Asp Glu Ala Glu Ser His Thr Leu Thr Tyr Pro Pro Glu Leu Trp Tyr 
            340                 345                 350         


Arg Lys Ile Cys Gly Phe Asp Val Leu Tyr Pro Pro Glu Arg Tyr Gly 
        355                 360                 365             


His Val Leu Ser Gly Trp Ile Cys Gly Glu Glu Ala Leu Val Met Glu 
    370                 375                 380                 


Lys Cys Asp Asp Glu Ala Val Ala Glu Ile Cys Thr Glu Met Leu Arg 
385                 390                 395                 400 


Gln Phe Thr Gly Asn Pro Asn Ile Pro Lys Pro Arg Arg Ile Leu Arg 
                405                 410                 415     


Ser Ala Trp Gly Ser Asn Pro Tyr Phe Arg Gly Ser Tyr Ser Tyr Thr 
            420                 425                 430         


Gln Val Gly Ser Ser Gly Ala Asp Val Glu Lys Leu Ala Lys Pro Leu 
        435                 440                 445             


Pro Tyr Thr Glu Ser Ser Lys Thr Ala Pro Met Gln Val Leu Phe Ser 
    450                 455                 460                 


Gly Glu Ala Thr His Arg Lys Tyr Tyr Ser Thr Thr His Gly Ala Leu 
465                 470                 475                 480 


Leu Ser Gly Gln Arg Glu Ala Ala Arg Leu Ile Glu Met Tyr Arg Asp 
                485                 490                 495     


Leu Phe Gln Gln Gly Thr 
            500         


<210> 5685
<211> 192
<212> PRT
<213> Homo sapiens

<400> 5685
Met Gly Thr Phe Asp Leu Trp Thr Asp Tyr Leu Gly Leu Ala His Leu 
1               5                   10                  15      


Val Arg Ala Leu Ser Gly Lys Glu Gly Pro Glu Thr Arg Leu Ser Pro 
            20                  25                  30          


Gln Pro Glu Pro Glu Pro Met Leu Glu Pro Val Ser Ala Leu Glu Pro 
        35                  40                  45              


Met Pro Ala Pro Glu Ser Val Pro Val Pro Gly Pro Lys Asp Gln Lys 
    50                  55                  60                  


Arg Ser Leu Glu Ser Ser Pro Ala Pro Glu Arg Leu Cys Ser Phe Cys 
65                  70                  75                  80  


Lys His Asn Gly Glu Ser Arg Ala Ile Tyr Gln Ser His Val Leu Lys 
                85                  90                  95      


Asp Glu Ala Gly Arg Val Leu Cys Pro Ile Leu Arg Asp Tyr Val Cys 
            100                 105                 110         


Pro Gln Cys Gly Ala Thr Arg Glu Arg Ala His Thr Arg Arg Phe Cys 
        115                 120                 125             


Pro Leu Thr Gly Gln Gly Tyr Thr Ser Val Tyr Ser His Thr Thr Arg 
    130                 135                 140                 


Asn Ser Ala Gly Lys Lys Leu Val Arg Pro Asp Lys Ala Lys Thr Gln 
145                 150                 155                 160 


Asp Thr Gly His Arg Arg Gly Gly Gly Gly Gly Ala Gly Phe Arg Gly 
                165                 170                 175     


Ala Gly Lys Ser Glu Pro Ser Pro Ser Cys Ser Pro Ser Met Ser Thr 
            180                 185                 190         


<210> 5686
<211> 855
<212> PRT
<213> Homo sapiens

<400> 5686
Met Ala Val Glu Asp Ser Thr Leu Gln Val Val Val Arg Val Arg Pro 
1               5                   10                  15      


Pro Thr Pro Arg Glu Leu Asp Ser Gln Arg Arg Pro Val Val Gln Val 
            20                  25                  30          


Val Asp Glu Arg Val Leu Val Phe Asn Pro Glu Glu Pro Asp Gly Gly 
        35                  40                  45              


Phe Pro Gly Leu Lys Trp Gly Gly Thr His Asp Gly Pro Lys Lys Lys 
    50                  55                  60                  


Gly Lys Asp Leu Thr Phe Val Phe Asp Arg Val Phe Gly Glu Ala Ala 
65                  70                  75                  80  


Thr Gln Gln Asp Val Phe Gln His Thr Thr His Ser Val Leu Asp Ser 
                85                  90                  95      


Phe Leu Gln Gly Tyr Asn Cys Ser Val Phe Ala Tyr Gly Ala Thr Gly 
            100                 105                 110         


Ala Gly Lys Thr His Thr Met Leu Gly Arg Glu Gly Asp Pro Gly Ile 
        115                 120                 125             


Met Tyr Leu Thr Thr Val Glu Leu Tyr Arg Arg Leu Glu Ala Arg Gln 
    130                 135                 140                 


Gln Glu Lys His Phe Glu Val Leu Ile Ser Tyr Gln Glu Val Tyr Asn 
145                 150                 155                 160 


Glu Gln Ile His Asp Leu Leu Glu Pro Lys Gly Pro Leu Ala Ile Arg 
                165                 170                 175     


Glu Asp Pro Asp Lys Gly Val Val Val Gln Gly Leu Ser Phe His Gln 
            180                 185                 190         


Pro Ala Ser Ala Glu Gln Leu Leu Glu Ile Leu Thr Arg Gly Asn Arg 
        195                 200                 205             


Asn Arg Thr Gln His Pro Thr Asp Ala Asn Ala Thr Ser Ser Arg Ser 
    210                 215                 220                 


His Ala Ile Phe Gln Ile Phe Val Lys Gln Gln Asp Arg Val Pro Gly 
225                 230                 235                 240 


Leu Thr Gln Ala Val Gln Val Ala Lys Met Ser Leu Ile Asp Leu Ala 
                245                 250                 255     


Gly Ser Glu Arg Ala Ser Ser Thr His Ala Lys Gly Glu Arg Leu Arg 
            260                 265                 270         


Glu Gly Ala Asn Ile Asn Arg Ser Leu Leu Ala Leu Ile Asn Val Leu 
        275                 280                 285             


Asn Ala Leu Ala Asp Ala Lys Gly Arg Lys Thr His Val Pro Tyr Arg 
    290                 295                 300                 


Asp Ser Lys Leu Thr Arg Leu Leu Lys Asp Ser Leu Gly Gly Asn Cys 
305                 310                 315                 320 


Arg Thr Val Met Ile Ala Ala Ile Ser Pro Ser Ser Leu Thr Tyr Glu 
                325                 330                 335     


Asp Thr Tyr Asn Thr Leu Lys Tyr Ala Asp Arg Ala Lys Glu Ile Arg 
            340                 345                 350         


Leu Ser Leu Lys Ser Asn Val Thr Ser Leu Asp Cys His Ile Ser Gln 
        355                 360                 365             


Tyr Ala Thr Ile Cys Gln Gln Leu Gln Ala Glu Val Ala Ala Leu Arg 
    370                 375                 380                 


Lys Lys Leu Gln Val Tyr Glu Gly Gly Gly Gln Pro Pro Pro Gln Asp 
385                 390                 395                 400 


Leu Pro Gly Ser Pro Lys Ser Gly Pro Pro Pro Glu His Leu Pro Ser 
                405                 410                 415     


Ser Pro Leu Pro Pro His Pro Pro Ser Gln Pro Cys Thr Pro Glu Leu 
            420                 425                 430         


Pro Ala Gly Pro Arg Ala Leu Gln Glu Glu Ser Leu Gly Met Glu Ala 
        435                 440                 445             


Gln Val Glu Arg Ala Met Glu Gly Asn Ser Ser Asp Gln Glu Gln Ser 
    450                 455                 460                 


Pro Glu Asp Glu Asp Glu Gly Pro Ala Glu Glu Val Pro Thr Gln Met 
465                 470                 475                 480 


Pro Glu Gln Asn Pro Thr His Ala Leu Pro Glu Ser Pro Arg Leu Thr 
                485                 490                 495     


Leu Gln Pro Lys Pro Val Val Gly His Phe Ser Ala Arg Glu Leu Asp 
            500                 505                 510         


Gly Asp Arg Ser Lys Gln Leu Ala Leu Lys Val Leu Cys Val Ala Gln 
        515                 520                 525             


Arg Gln Tyr Ser Leu Leu Gln Ala Ala Asn Leu Leu Thr Pro Asp Met 
    530                 535                 540                 


Ile Thr Glu Phe Glu Thr Leu Gln Gln Leu Val Gln Glu Glu Lys Ile 
545                 550                 555                 560 


Glu Pro Gly Ala Glu Ala Leu Arg Thr Ser Gly Leu Ala Arg Gly Ala 
                565                 570                 575     


Pro Leu Ala Gln Glu Leu Cys Ser Glu Ser Lys Pro Pro Gly Tyr Thr 
            580                 585                 590         


Gly Pro Val Thr Arg Thr Met Ala Arg Arg Leu Ser Gly Pro Leu His 
        595                 600                 605             


Thr Leu Gly Ile Pro Pro Gly Pro Asn Cys Thr Pro Ala Gln Gly Ser 
    610                 615                 620                 


Arg Trp Pro Met Glu Lys Lys Arg Arg Arg Pro Ser Ala Leu Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Met Ala Pro Lys Arg Gly Thr Lys Arg Gln Arg Gln Ser 
                645                 650                 655     


Phe Leu Pro Cys Leu Arg Arg Gly Ser Leu Pro Asp Thr Gln Pro Ser 
            660                 665                 670         


Gln Gly Pro Ser Thr Pro Lys Gly Glu Arg Ala Ser Ser Pro Cys His 
        675                 680                 685             


Ser Pro Arg Val Cys Pro Ala Thr Val Ile Lys Ser Arg Val Pro Leu 
    690                 695                 700                 


Gly Pro Ser Ala Met Gln Asn Cys Ser Thr Pro Leu Ala Leu Pro Thr 
705                 710                 715                 720 


Arg Asp Leu Asn Ala Thr Phe Asp Leu Ser Glu Glu Pro Pro Ser Lys 
                725                 730                 735     


Pro Ser Phe His Glu Cys Ile Gly Trp Asp Lys Ile Pro Gln Glu Leu 
            740                 745                 750         


Ser Arg Leu Asp Gln Pro Phe Ile Pro Arg Ala Pro Val Pro Leu Phe 
        755                 760                 765             


Thr Met Lys Gly Pro Lys Pro Thr Ser Ser Leu Pro Gly Thr Ser Ala 
    770                 775                 780                 


Cys Lys Lys Lys Arg Val Ala Ser Ser Ser Val Ser His Gly Arg Ser 
785                 790                 795                 800 


Arg Ile Ala Arg Leu Pro Ser Ser Thr Leu Lys Arg Pro Ala Gly Pro 
                805                 810                 815     


Leu Val Leu Pro Glu Leu Pro Leu Ser Pro Leu Cys Pro Ser Asn Arg 
            820                 825                 830         


Arg Asn Gly Lys Asp Leu Ile Arg Val Gly Arg Ala Leu Ser Ala Gly 
        835                 840                 845             


Asn Gly Val Thr Lys Val Ser 
    850                 855 


<210> 5687
<211> 147
<212> PRT
<213> Homo sapiens

<400> 5687
Met Trp Lys Phe Pro Gly Gly Leu Ser Glu Pro Glu Glu Asp Ile Gly 
1               5                   10                  15      


Asp Thr Ala Val Arg Glu Val Phe Glu Glu Thr Gly Ile Lys Ser Glu 
            20                  25                  30          


Phe Arg Ser Val Leu Ser Ile Arg Gln Gln His Thr Asn Pro Gly Ala 
        35                  40                  45              


Phe Gly Lys Ser Asp Met Tyr Ile Ile Cys Arg Leu Lys Pro Tyr Ser 
    50                  55                  60                  


Phe Thr Ile Asn Phe Cys Gln Glu Glu Cys Leu Arg Cys Glu Trp Met 
65                  70                  75                  80  


Asp Leu Asn Asp Leu Ala Lys Thr Glu Asn Thr Thr Pro Ile Thr Ser 
                85                  90                  95      


Arg Val Ala Arg Leu Leu Leu Tyr Gly Tyr Arg Glu Gly Phe Asp Lys 
            100                 105                 110         


Ile Asp Leu Thr Val Glu Glu Leu Pro Ala Val Tyr Thr Gly Leu Phe 
        115                 120                 125             


Tyr Lys Leu Tyr His Lys Glu Leu Pro Glu Asn Tyr Lys Thr Met Lys 
    130                 135                 140                 


Gly Ile Asp 
145         


<210> 5688
<211> 1108
<212> PRT
<213> Homo sapiens

<400> 5688
Met Ala Leu Arg Pro Gly Ala Gly Ser Gly Gly Gly Gly Ala Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ser Ala Gly Gly Gly Gly Phe Met Phe Pro Val Ala 
            20                  25                  30          


Gly Gly Ile Arg Pro Pro Gln Ala Gly Leu Met Pro Met Gln Gln Gln 
        35                  40                  45              


Gly Phe Pro Met Val Ser Val Met Gln Pro Asn Met Gln Gly Ile Met 
    50                  55                  60                  


Gly Met Asn Tyr Ser Ser Gln Met Ser Gln Gly Pro Ile Ala Met Gln 
65                  70                  75                  80  


Ala Gly Ile Pro Met Gly Pro Met Pro Ala Ala Gly Met Pro Tyr Leu 
                85                  90                  95      


Gly Gln Ala Pro Phe Leu Gly Met Arg Pro Pro Gly Pro Gln Tyr Thr 
            100                 105                 110         


Pro Asp Met Gln Lys Gln Phe Ala Glu Glu Gln Gln Lys Arg Phe Glu 
        115                 120                 125             


Gln Gln Gln Lys Leu Leu Glu Glu Glu Arg Lys Arg Arg Gln Phe Glu 
    130                 135                 140                 


Glu Gln Lys Gln Lys Leu Arg Leu Leu Ser Ser Val Lys Pro Lys Thr 
145                 150                 155                 160 


Gly Glu Lys Ser Arg Asp Asp Ala Leu Glu Ala Ile Lys Gly Asn Leu 
                165                 170                 175     


Asp Gly Phe Ser Arg Asp Ala Lys Met His Pro Thr Pro Ala Ser His 
            180                 185                 190         


Pro Lys Lys Pro Gly Val Gly Val Phe Pro Ser Gln Asp Pro Ala Gln 
        195                 200                 205             


Pro Arg Met Pro Pro Trp Ile Tyr Asn Glu Ser Leu Val Pro Asp Ala 
    210                 215                 220                 


Tyr Lys Lys Ile Leu Glu Thr Thr Met Thr Pro Thr Gly Ile Asp Thr 
225                 230                 235                 240 


Ala Lys Leu Tyr Pro Ile Leu Met Ser Ser Gly Leu Pro Arg Glu Thr 
                245                 250                 255     


Leu Gly Gln Ile Trp Ala Leu Ala Asn Arg Thr Thr Pro Gly Lys Leu 
            260                 265                 270         


Thr Lys Glu Glu Leu Tyr Thr Val Leu Ala Met Ile Ala Val Thr Gln 
        275                 280                 285             


Val Val Lys Pro Glu Glu Asp Asp Phe Gln Asp Phe Gln Asp Ala Ser 
    290                 295                 300                 


Lys Ser Gly Ser Leu Asp Asp Ser Phe Ser Asp Phe Gln Glu Leu Pro 
305                 310                 315                 320 


Ala Ser Ser Lys Thr Ser Asn Ser Gln His Gly Asn Ser Ala Pro Ser 
                325                 330                 335     


Leu Leu Met Pro Leu Pro Gly Thr Lys Ala Leu Pro Ser Met Asp Lys 
            340                 345                 350         


Tyr Ala Val Phe Lys Gly Ile Ala Ala Asp Lys Ser Ser Glu Asn Thr 
        355                 360                 365             


Val Pro Pro Gly Asp Pro Gly Asp Lys Tyr Ser Ala Phe Arg Glu Leu 
    370                 375                 380                 


Glu Gln Thr Ala Glu Asn Lys Pro Leu Gly Glu Ser Phe Ala Glu Phe 
385                 390                 395                 400 


Arg Ser Ala Gly Thr Asp Asp Gly Phe Thr Asp Phe Lys Thr Ala Asp 
                405                 410                 415     


Ser Val Ser Pro Leu Glu Pro Pro Thr Lys Asp Lys Thr Phe Pro Pro 
            420                 425                 430         


Ser Phe Pro Ser Gly Thr Ile Gln Gln Lys Gln Gln Thr Gln Val Lys 
        435                 440                 445             


Asn Pro Leu Asn Leu Ala Asp Leu Asp Met Phe Ser Ser Val Asn Cys 
    450                 455                 460                 


Ser Ser Glu Lys Pro Leu Ser Phe Ser Ala Val Phe Ser Thr Ser Lys 
465                 470                 475                 480 


Ser Val Ser Thr Pro Gln Ser Thr Gly Ser Ala Ala Thr Met Thr Ala 
                485                 490                 495     


Leu Ala Ala Thr Lys Thr Ser Ser Leu Ala Asp Asp Phe Gly Glu Phe 
            500                 505                 510         


Ser Leu Phe Gly Glu Tyr Ser Gly Leu Ala Pro Val Gly Glu Gln Asp 
        515                 520                 525             


Asp Phe Ala Asp Phe Met Ala Phe Ser Asn Ser Ser Ile Ser Ser Glu 
    530                 535                 540                 


Gln Lys Pro Asp Asp Lys Tyr Asp Ala Leu Lys Glu Glu Ala Ser Pro 
545                 550                 555                 560 


Val Pro Leu Thr Ser Asn Val Gly Ser Thr Val Lys Gly Gly Gln Asn 
                565                 570                 575     


Ser Thr Ala Ala Ser Thr Lys Tyr Asp Val Phe Arg Gln Leu Ser Leu 
            580                 585                 590         


Glu Gly Ser Gly Leu Gly Val Glu Asp Leu Lys Asp Asn Thr Pro Ser 
        595                 600                 605             


Gly Lys Ser Asp Asp Asp Phe Ala Asp Phe His Ser Ser Lys Phe Ser 
    610                 615                 620                 


Ser Ile Asn Ser Asp Lys Ser Leu Gly Glu Lys Ala Val Ala Phe Arg 
625                 630                 635                 640 


His Thr Lys Glu Asp Ser Ala Ser Val Lys Ser Leu Asp Leu Pro Ser 
                645                 650                 655     


Ile Gly Gly Ser Ser Val Gly Lys Glu Asp Ser Glu Asp Ala Leu Ser 
            660                 665                 670         


Val Gln Phe Asp Met Lys Leu Ala Asp Val Gly Gly Asp Leu Lys His 
        675                 680                 685             


Val Met Ser Asp Ser Ser Leu Asp Leu Pro Thr Val Ser Gly Gln His 
    690                 695                 700                 


Pro Pro Ala Ala Ala Gly Ser Gly Ser Pro Ser Ala Thr Ser Ile Leu 
705                 710                 715                 720 


Gln Lys Lys Glu Thr Ser Phe Gly Ser Ser Glu Asn Ile Thr Met Thr 
                725                 730                 735     


Ser Leu Ser Lys Val Thr Thr Phe Val Ser Glu Asp Ala Leu Pro Glu 
            740                 745                 750         


Thr Thr Phe Pro Ala Leu Ala Ser Phe Lys Asp Thr Ile Pro Gln Thr 
        755                 760                 765             


Ser Glu Gln Lys Glu Tyr Glu Asn Arg Asp Tyr Lys Asp Phe Thr Lys 
    770                 775                 780                 


Gln Asp Leu Pro Thr Ala Glu Arg Ser Gln Glu Ala Thr Cys Pro Ser 
785                 790                 795                 800 


Pro Ala Ser Ser Gly Ala Ser Gln Glu Thr Pro Asn Glu Cys Ser Asp 
                805                 810                 815     


Asp Phe Gly Glu Phe Gln Ser Glu Lys Pro Lys Ile Ser Lys Phe Asp 
            820                 825                 830         


Phe Leu Val Ala Thr Ser Gln Ser Lys Met Lys Ser Ser Glu Glu Met 
        835                 840                 845             


Ile Lys Ser Glu Leu Ala Thr Phe Asp Leu Ser Val Gln Gly Ser His 
    850                 855                 860                 


Lys Arg Ser Leu Ser Leu Gly Asp Lys Glu Ile Ser Arg Ser Ser Pro 
865                 870                 875                 880 


Ser Pro Ala Leu Glu Gln Pro Phe Arg Asp Arg Ser Asn Thr Leu Asn 
                885                 890                 895     


Glu Lys Pro Ala Leu Pro Val Ile Arg Asp Lys Tyr Lys Asp Leu Thr 
            900                 905                 910         


Gly Glu Val Glu Glu Asn Glu Arg Tyr Ala Tyr Glu Trp Gln Arg Cys 
        915                 920                 925             


Leu Gly Ser Ala Leu Asn Val Ile Lys Lys Ala Asn Asp Thr Leu Asn 
    930                 935                 940                 


Gly Ile Ser Ser Ser Ser Val Cys Thr Glu Val Ile Gln Ser Ala Gln 
945                 950                 955                 960 


Gly Met Glu Tyr Leu Leu Gly Val Val Glu Val Tyr Arg Val Thr Lys 
                965                 970                 975     


Arg Val Glu Leu Gly Ile Lys Ala Thr Ala Val Cys Ser Glu Lys Leu 
            980                 985                 990         


Gln Gln Leu Leu Lys Asp Ile Asp  Lys Val Trp Asn Asn  Leu Ile Gly 
        995                 1000                 1005             


Phe Met  Ser Leu Ala Thr Leu  Thr Pro Asp Glu Asn  Ser Leu Asp 
    1010                 1015                 1020             


Phe Ser  Ser Cys Met Leu Arg  Pro Gly Ile Lys Asn  Ala Gln Glu 
    1025                 1030                 1035             


Leu Ala  Cys Gly Val Cys Leu  Leu Asn Val Asp Ser  Arg Ser Arg 
    1040                 1045                 1050             


Lys Glu  Glu Lys Pro Ala Glu  Glu His Pro Lys Lys  Ala Phe Asn 
    1055                 1060                 1065             


Ser Glu  Thr Asp Ser Phe Lys  Leu Ala Tyr Gly Gly  His Gln Tyr 
    1070                 1075                 1080             


His Ala  Ser Cys Ala Asn Phe  Trp Ile Asn Cys Val  Glu Pro Lys 
    1085                 1090                 1095             


Pro Pro  Gly Leu Val Leu Pro  Asp Leu Leu 
    1100                 1105             


<210> 5689
<211> 418
<212> PRT
<213> Homo sapiens

<400> 5689
Met Glu Thr His Ile Ser Cys Leu Phe Pro Glu Leu Leu Ala Met Ile 
1               5                   10                  15      


Phe Gly Tyr Leu Asp Val Arg Asp Lys Gly Arg Ala Ala Gln Val Cys 
            20                  25                  30          


Thr Ala Trp Arg Asp Ala Ala Tyr His Lys Ser Val Trp Arg Gly Val 
        35                  40                  45              


Glu Ala Lys Leu His Leu Arg Arg Ala Asn Pro Ser Leu Phe Pro Ser 
    50                  55                  60                  


Leu Gln Ala Arg Gly Ile Arg Arg Val Gln Ile Leu Ser Leu Arg Arg 
65                  70                  75                  80  


Ser Leu Ser Tyr Val Ile Gln Gly Met Ala Asn Ile Glu Ser Leu Asn 
                85                  90                  95      


Leu Ser Gly Cys Tyr Asn Leu Thr Asp Asn Gly Leu Gly His Ala Phe 
            100                 105                 110         


Val Gln Glu Ile Gly Ser Leu Arg Ala Leu Asn Leu Ser Leu Cys Lys 
        115                 120                 125             


Gln Ile Thr Asp Ser Ser Leu Gly Arg Ile Ala Gln Tyr Leu Lys Gly 
    130                 135                 140                 


Leu Glu Val Leu Glu Leu Gly Gly Cys Ser Asn Ile Thr Asn Thr Gly 
145                 150                 155                 160 


Leu Leu Leu Ile Ala Trp Gly Leu Gln Arg Leu Lys Ser Leu Asn Leu 
                165                 170                 175     


Arg Ser Cys Arg His Leu Ser Asp Val Gly Ile Gly His Leu Ala Gly 
            180                 185                 190         


Met Thr Arg Ser Ala Ala Glu Gly Cys Leu Gly Leu Glu Gln Leu Thr 
        195                 200                 205             


Leu Gln Asp Cys Gln Lys Leu Thr Asp Leu Ser Leu Lys His Ile Ser 
    210                 215                 220                 


Arg Gly Leu Thr Gly Leu Arg Leu Leu Asn Leu Ser Phe Cys Gly Gly 
225                 230                 235                 240 


Ile Ser Asp Ala Gly Leu Leu His Leu Ser His Met Gly Ser Leu Arg 
                245                 250                 255     


Ser Leu Asn Leu Arg Ser Cys Asp Asn Ile Ser Asp Thr Gly Ile Met 
            260                 265                 270         


His Leu Ala Met Gly Ser Leu Arg Leu Ser Gly Leu Asp Val Ser Phe 
        275                 280                 285             


Cys Asp Lys Val Gly Asp Gln Ser Leu Ala Tyr Ile Ala Gln Gly Leu 
    290                 295                 300                 


Asp Gly Leu Lys Ser Leu Ser Leu Cys Ser Cys His Ile Ser Asp Asp 
305                 310                 315                 320 


Gly Ile Asn Arg Met Val Arg Gln Met His Gly Leu Arg Thr Leu Asn 
                325                 330                 335     


Ile Gly Gln Cys Val Arg Ile Thr Asp Lys Gly Leu Glu Leu Ile Ala 
            340                 345                 350         


Glu His Leu Ser Gln Leu Thr Gly Ile Asp Leu Tyr Gly Cys Thr Arg 
        355                 360                 365             


Ile Thr Lys Arg Gly Leu Glu Arg Ile Thr Gln Leu Pro Cys Leu Lys 
    370                 375                 380                 


Val Leu Asn Leu Gly Leu Trp Gln Met Thr Asp Ser Glu Lys Glu Ala 
385                 390                 395                 400 


Arg Gly Asp Phe Ser Pro Leu Phe Thr Val Arg Thr Arg Gly Ser Ser 
                405                 410                 415     


Arg Arg 
        


<210> 5690
<211> 456
<212> PRT
<213> Homo sapiens

<400> 5690
Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His 
    130                 135                 140                 


Trp Gln Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala 
145                 150                 155                 160 


Ala Arg Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu 
                165                 170                 175     


Ile Arg Ala Arg Asn Pro Ala Phe Gln Pro Gln Thr Leu Met Asp Phe 
            180                 185                 190         


Gly Ser Gly Thr Gly Ser Val Thr Trp Ala Ala His Ser Ile Trp Gly 
        195                 200                 205             


Gln Ser Leu Arg Glu Tyr Met Cys Val Asp Arg Ser Ala Ala Met Leu 
    210                 215                 220                 


Val Leu Ala Glu Lys Leu Leu Lys Gly Gly Ser Glu Ser Gly Glu Pro 
225                 230                 235                 240 


Tyr Ile Pro Gly Val Phe Phe Arg Gln Phe Leu Pro Val Ser Pro Lys 
                245                 250                 255     


Val Gln Phe Asp Val Val Val Ser Ala Phe Ser Leu Ser Glu Leu Pro 
            260                 265                 270         


Ser Lys Ala Asp Arg Thr Glu Val Val Gln Thr Leu Trp Arg Lys Thr 
        275                 280                 285             


Gly His Phe Leu Val Leu Val Glu Asn Gly Thr Lys Ala Gly His Ser 
    290                 295                 300                 


Leu Leu Met Asp Ala Arg Asp Leu Val Leu Lys Gly Lys Glu Lys Ser 
305                 310                 315                 320 


Pro Leu Asp Pro Arg Pro Gly Phe Val Phe Ala Pro Cys Pro His Glu 
                325                 330                 335     


Leu Pro Cys Pro Gln Leu Thr Asn Leu Ala Cys Ser Phe Ser Gln Ala 
            340                 345                 350         


Tyr His Pro Ile Pro Phe Ser Trp Asn Lys Lys Pro Lys Glu Glu Lys 
        355                 360                 365             


Phe Ser Met Val Ile Leu Ala Arg Gly Ser Pro Glu Glu Ala His Arg 
    370                 375                 380                 


Trp Pro Arg Ile Thr Gln Pro Val Leu Lys Arg Pro Arg His Val His 
385                 390                 395                 400 


Cys His Leu Cys Cys Pro Asp Gly His Met Gln His Ala Val Leu Thr 
                405                 410                 415     


Ala Arg Arg His Gly Arg Asp Leu Tyr Arg Cys Ala Arg Val Ser Ser 
            420                 425                 430         


Trp Gly Asp Leu Leu Pro Val Leu Thr Pro Ser Ala Phe Pro Pro Ser 
        435                 440                 445             


Thr Ala Gln Asp Pro Ser Glu Ser 
    450                 455     


<210> 5691
<211> 251
<212> PRT
<213> Homo sapiens

<400> 5691
Met Asp Met Lys Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ala Ala Val Arg Glu Leu Val Leu Asp Asn Cys Lys Ser Asn Asp Gly 
            20                  25                  30          


Lys Ile Glu Gly Leu Thr Ala Glu Phe Val Asn Leu Glu Phe Leu Ser 
        35                  40                  45              


Leu Ile Asn Val Gly Leu Ile Ser Val Ser Asn Leu Pro Lys Leu Pro 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Glu Asn Arg Ile Phe Gly Gly Leu 
65                  70                  75                  80  


Asp Met Leu Ala Glu Lys Leu Pro Asn Leu Thr His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Leu Lys Asp Ile Ser Thr Leu Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Cys Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Ser Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Glu Asp Gln Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Val Asp Gly Val Asp Glu Glu Glu Glu Asp Glu Glu Gly Glu Asp 
                165                 170                 175     


Glu Glu Asp Glu Asp Asp Glu Asp Gly Glu Glu Glu Glu Phe Asp Glu 
            180                 185                 190         


Glu Asp Asp Glu Asp Glu Asp Val Glu Gly Asp Glu Asp Asp Asp Glu 
        195                 200                 205             


Val Ser Glu Glu Glu Glu Glu Phe Gly Leu Asp Glu Glu Asp Glu Asp 
    210                 215                 220                 


Glu Asp Glu Asp Glu Glu Glu Glu Glu Gly Gly Lys Gly Glu Lys Arg 
225                 230                 235                 240 


Lys Arg Glu Thr Asp Asp Glu Gly Glu Asp Asp 
                245                 250     


<210> 5692
<211> 169
<212> PRT
<213> Homo sapiens

<400> 5692
Met Ser Ala Pro Pro Ala Leu Gln Ile Arg Glu Ala Asn Ala His Leu 
1               5                   10                  15      


Ala Ala Val His Arg Arg Ala Ala Glu Leu Glu Ala Arg Leu Asp Ala 
            20                  25                  30          


Ala Glu Arg Thr Val His Ala Gln Ala Glu Arg Leu Ala Leu His Asp 
        35                  40                  45              


Gln Gln Leu Arg Ala Ala Leu Asp Glu Leu Gly Arg Ala Lys Asp Arg 
    50                  55                  60                  


Glu Ile Ala Thr Leu Gln Glu Gln Leu Met Thr Ser Glu Ala Thr Val 
65                  70                  75                  80  


His Ser Leu Gln Ala Thr Val His Gln Arg Asp Glu Leu Ile Arg Gln 
                85                  90                  95      


Leu Gln Pro Arg Ala Glu Leu Leu Gln Asp Ile Cys Arg Arg Arg Pro 
            100                 105                 110         


Pro Leu Ala Gly Leu Leu Asp Ala Leu Ala Glu Ala Glu Arg Leu Gly 
        115                 120                 125             


Pro Leu Pro Ala Ser Asp Pro Gly His Pro Pro Pro Gly Gly Pro Gly 
    130                 135                 140                 


Pro Pro Leu Asp Asn Ser Thr Gly Glu Glu Ala Asp Arg Asp His Leu 
145                 150                 155                 160 


Gln Pro Ala Val Phe Gly Thr Thr Val 
                165                 


<210> 5693
<211> 692
<212> PRT
<213> Homo sapiens

<400> 5693
Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr Gly Ser Val Glu 
1               5                   10                  15      


Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln Glu Ile Ala Arg 
            20                  25                  30          


Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg Asn Val Lys Tyr 
        35                  40                  45              


Tyr Gln Gly Ile Arg Ala Ala Val Ser Arg Val Lys Asp Arg Gly Gln 
    50                  55                  60                  


Lys Ala Leu Val Leu Asp Ile Gly Thr Gly Thr Gly Leu Leu Ser Met 
65                  70                  75                  80  


Met Ala Val Thr Ala Gly Ala Asp Phe Cys Tyr Ala Ile Glu Val Phe 
                85                  90                  95      


Lys Pro Met Ala Asp Ala Ala Val Lys Ile Val Glu Lys Asn Gly Phe 
            100                 105                 110         


Ser Asp Lys Ile Lys Val Ile Asn Lys His Ser Thr Glu Val Thr Val 
        115                 120                 125             


Gly Pro Glu Gly Asp Met Pro Cys Arg Ala Asn Ile Leu Val Thr Glu 
    130                 135                 140                 


Leu Phe Asp Thr Glu Leu Ile Gly Glu Gly Ala Leu Pro Ser Tyr Glu 
145                 150                 155                 160 


His Ala His Arg His Leu Val Glu Glu Asn Cys Glu Ala Val Pro His 
                165                 170                 175     


Arg Ala Thr Val Tyr Ala Gln Leu Val Glu Ser Gly Arg Met Trp Ser 
            180                 185                 190         


Trp Asn Lys Leu Phe Pro Ile His Val Gln Thr Ser Leu Gly Glu Gln 
        195                 200                 205             


Val Ile Val Pro Pro Val Asp Val Glu Ser Cys Pro Gly Ala Pro Ser 
    210                 215                 220                 


Val Cys Asp Ile Gln Leu Asn Gln Val Ser Pro Ala Asp Phe Thr Val 
225                 230                 235                 240 


Leu Ser Asp Val Leu Pro Met Phe Ser Ile Asp Phe Ser Lys Gln Val 
                245                 250                 255     


Ser Ser Ser Ala Ala Cys His Ser Arg Arg Phe Glu Pro Leu Thr Ser 
            260                 265                 270         


Gly Arg Ala Gln Val Val Leu Ser Trp Trp Asp Ile Glu Met Asp Pro 
        275                 280                 285             


Glu Gly Lys Ile Lys Cys Thr Met Ala Pro Phe Trp Ala His Ser Asp 
    290                 295                 300                 


Pro Glu Glu Met Gln Trp Arg Asp His Trp Met Gln Cys Val Tyr Phe 
305                 310                 315                 320 


Leu Pro Gln Glu Glu Pro Val Val Gln Gly Ser Ala Leu Tyr Leu Val 
                325                 330                 335     


Ala His His Asp Asp Tyr Cys Val Trp Tyr Ser Leu Gln Arg Thr Ser 
            340                 345                 350         


Pro Glu Lys Asn Glu Arg Val Arg Gln Met Arg Pro Val Cys Asp Cys 
        355                 360                 365             


Gln Ala His Leu Leu Trp Asn Arg Pro Arg Phe Gly Glu Ile Asn Asp 
    370                 375                 380                 


Gln Asp Arg Thr Asp Arg Tyr Val Gln Ala Leu Arg Thr Val Leu Lys 
385                 390                 395                 400 


Pro Asp Ser Val Cys Leu Cys Val Ser Asp Gly Ser Leu Leu Ser Val 
                405                 410                 415     


Leu Ala His His Leu Gly Val Glu Gln Val Phe Thr Val Glu Ser Ser 
            420                 425                 430         


Ala Ala Ser His Lys Leu Leu Arg Lys Ile Phe Lys Ala Asn His Leu 
        435                 440                 445             


Glu Asp Lys Ile Asn Ile Ile Glu Lys Arg Pro Glu Leu Leu Thr Asn 
    450                 455                 460                 


Glu Asp Leu Gln Gly Arg Lys Val Ser Leu Leu Leu Gly Glu Pro Phe 
465                 470                 475                 480 


Phe Thr Thr Ser Leu Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val 
                485                 490                 495     


Arg Thr Ala Val Asp Gln His Leu Gly Pro Gly Ala Met Val Met Pro 
            500                 505                 510         


Gln Ala Ala Ser Leu His Ala Val Val Val Glu Phe Arg Asp Leu Trp 
        515                 520                 525             


Arg Ile Arg Ser Pro Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile 
    530                 535                 540                 


Met Asp Asp Met Ile Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu 
545                 550                 555                 560 


Ala Glu Pro His Pro Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu 
                565                 570                 575     


Pro Trp Gln Ile Leu Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln 
            580                 585                 590         


Pro Leu Cys Ala Glu Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser 
        595                 600                 605             


His Ala Ala Val Leu Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr 
    610                 615                 620                 


Leu Ser Thr Gly Leu Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys 
625                 630                 635                 640 


Trp Asn Pro His Cys Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro 
                645                 650                 655     


Asp Pro Arg Ala Leu Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val 
            660                 665                 670         


Glu Phe His Pro Asp Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala 
        675                 680                 685             


Asp Thr Pro Asp 
    690         


<210> 5694
<211> 155
<212> PRT
<213> Homo sapiens

<400> 5694
Met Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val 
1               5                   10                  15      


Pro Leu Ala Gly Ala Ala Gly Gly Pro Gly Ile Gly Arg Ala Ala Gly 
            20                  25                  30          


Arg Gly Ile Pro Ala Gly Val Pro Met Pro Gln Ala Pro Ala Gly Leu 
        35                  40                  45              


Ala Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr 
    50                  55                  60                  


Pro Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr Ala 
65                  70                  75                  80  


Ser Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Gly Pro 
                85                  90                  95      


Pro Pro Pro Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly Pro 
            100                 105                 110         


Pro Pro Gly Met Arg Pro Pro Met Gly Pro Pro Met Gly Ile Pro Pro 
        115                 120                 125             


Gly Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met Arg Pro Pro 
    130                 135                 140                 


Pro Pro Gly Met Arg Gly Lys Cys Leu Gln Trp 
145                 150                 155 


<210> 5695
<211> 133
<212> PRT
<213> Homo sapiens

<400> 5695
Met Thr Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Gln Ser Asp Ser Val Lys Gly Lys Arg Arg Asp Asp Gly Leu Ser 
            20                  25                  30          


Ala Ala Ala Arg Lys Gln Ser Ala Pro Ser Ser Leu Pro Pro Gly Thr 
        35                  40                  45              


Arg Arg Ser Cys Ser Arg Ser Arg Lys Arg Gln Thr Arg Arg Arg Arg 
    50                  55                  60                  


Asn Pro Ser Ser Phe Val Ala Ser Cys Pro Thr Leu Leu Pro Phe Ala 
65                  70                  75                  80  


Cys Val Pro Gly Ala Ser Pro Thr Thr Leu Ala Phe Pro Pro Val Val 
                85                  90                  95      


Leu Thr Gly Pro Ser Thr Asp Gly Ile Pro Phe Ala Leu Ser Leu Gln 
            100                 105                 110         


Arg Val Pro Phe Val Leu Pro Ser Pro Gln Val Ala Ser Leu Pro Leu 
        115                 120                 125             


Gly His Ser Arg Gly 
    130             


<210> 5696
<211> 602
<212> PRT
<213> Homo sapiens

<400> 5696
Met Ala Glu Phe Arg Val Arg Val Ser Thr Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Thr Trp Asp Lys Val Ser Val Ser Ile Val Gly Thr Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Thr Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Thr Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Thr Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Thr Leu Val Leu Gln Glu Gly Thr Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Thr Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Thr Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Thr Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Thr Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Thr Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Thr Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Thr Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Thr 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Thr Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Thr Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Thr His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Thr Leu Ala Thr Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Ser Thr Gly Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn 
                405                 410                 415     


Met Lys Gln Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg 
            420                 425                 430         


Thr Arg Gly Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly 
        435                 440                 445             


Met Gln Ile Trp Gly Ile Pro Ser Ser Leu Glu Thr Arg Glu Ala Leu 
    450                 455                 460                 


Val Gln Tyr Val Thr Met Val Ile Phe Thr Cys Ser Ala Lys His Ala 
465                 470                 475                 480 


Ala Val Ser Ala Gly Gln Phe Asp Ser Cys Ala Trp Met Pro Asn Leu 
                485                 490                 495     


Pro Pro Ser Met Gln Leu Pro Pro Pro Thr Ser Lys Gly Leu Ala Thr 
            500                 505                 510         


Cys Glu Gly Phe Ile Ala Thr Leu Pro Pro Val Asn Ala Thr Cys Asp 
        515                 520                 525             


Val Ile Leu Ala Leu Trp Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg 
    530                 535                 540                 


Pro Leu Gly Thr Tyr Pro Asp Glu His Phe Thr Glu Glu Ala Pro Arg 
545                 550                 555                 560 


Arg Ser Ile Ala Thr Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly 
                565                 570                 575     


Ile Gln Glu Arg Asn Gln Gly Leu Val Leu Pro Tyr Thr Tyr Leu Asp 
            580                 585                 590         


Pro Pro Leu Ile Glu Asn Ser Val Ser Ile 
        595                 600         


<210> 5697
<211> 1040
<212> PRT
<213> Homo sapiens

<400> 5697
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg 
            100                 105                 110         


Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys 
        115                 120                 125             


Thr Glu Ala Gln Asp Lys Asp Asn Arg Cys Arg Tyr Ile Leu Lys Thr 
    130                 135                 140                 


Lys Phe Arg Glu Met Trp Lys Ser Trp Pro Gly Asp Ser Lys Glu Val 
145                 150                 155                 160 


Gln Val Met Ala Glu Arg Tyr Lys Met Leu Ile Pro Phe Ser Asn Pro 
                165                 170                 175     


Arg Val Leu Pro Gly Pro Phe Ser Tyr Thr Val Val Leu Tyr Gly Pro 
            180                 185                 190         


Ala Gly Leu Gly Lys Thr Thr Leu Ala Gln Lys Leu Met Leu Asp Trp 
        195                 200                 205             


Ala Glu Asp Asn Leu Ile His Lys Phe Lys Tyr Ala Phe Tyr Leu Ser 
    210                 215                 220                 


Cys Arg Glu Leu Ser Arg Leu Gly Pro Cys Ser Phe Ala Glu Leu Val 
225                 230                 235                 240 


Phe Arg Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro His Ile Leu Ala 
                245                 250                 255     


Gln Ala Arg Lys Ile Leu Phe Val Ile Asp Gly Phe Asp Glu Leu Gly 
            260                 265                 270         


Ala Ala Pro Gly Ala Leu Ile Glu Asp Ile Cys Gly Asp Trp Glu Lys 
        275                 280                 285             


Lys Lys Pro Val Pro Val Leu Leu Gly Ser Leu Leu Asn Arg Val Met 
    290                 295                 300                 


Leu Pro Lys Ala Ala Leu Leu Val Thr Thr Arg Pro Arg Ala Leu Arg 
305                 310                 315                 320 


Asp Leu Arg Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val Glu Gly 
                325                 330                 335     


Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His Phe Gly Asp 
            340                 345                 350         


Glu Asp Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser Asn Ala Ala 
        355                 360                 365             


Leu Phe Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile Val Cys Thr 
    370                 375                 380                 


Thr Leu Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val Pro Thr Cys 
385                 390                 395                 400 


Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser Arg Phe Pro 
                405                 410                 415     


Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser Leu Leu Ala 
            420                 425                 430         


Ala Gln Gly Leu Trp Ala Gln Thr Ser Val Leu His Arg Glu Asp Leu 
        435                 440                 445             


Glu Arg Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe Leu Asp Gly 
    450                 455                 460                 


Asp Ile Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr Ser Phe Ile 
465                 470                 475                 480 


His Leu Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr Thr Leu Glu 
                485                 490                 495     


Lys Glu Glu Glu Glu Asp Arg Asp Gly His Thr Trp Asp Ile Gly Asp 
            500                 505                 510         


Val Gln Lys Leu Leu Ser Gly Val Glu Arg Leu Arg Asn Pro Asp Leu 
        515                 520                 525             


Ile Gln Ala Gly Tyr Tyr Ser Phe Gly Leu Ala Asn Glu Lys Arg Ala 
    530                 535                 540                 


Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro Asp Ile Lys 
545                 550                 555                 560 


Gln Glu Leu Leu Arg Cys Asp Ile Ser Cys Lys Gly Gly His Ser Thr 
                565                 570                 575     


Val Thr Asp Leu Gln Glu Leu Leu Gly Cys Leu Tyr Glu Ser Gln Glu 
            580                 585                 590         


Glu Glu Leu Val Lys Glu Val Met Ala Gln Phe Lys Glu Ile Ser Leu 
        595                 600                 605             


His Leu Asn Ala Val Asp Val Val Pro Ser Ser Phe Cys Val Lys His 
    610                 615                 620                 


Cys Arg Asn Leu Gln Lys Met Ser Leu Gln Val Ile Lys Glu Asn Leu 
625                 630                 635                 640 


Pro Glu Asn Val Thr Ala Ser Glu Ser Asp Ala Glu Val Glu Arg Ser 
                645                 650                 655     


Gln Asp Asp Gln His Met Leu Pro Phe Trp Thr Asp Leu Cys Ser Ile 
            660                 665                 670         


Phe Gly Ser Asn Lys Asp Leu Met Gly Leu Ala Ile Asn Asp Ser Phe 
        675                 680                 685             


Leu Ser Ala Ser Leu Val Arg Ile Leu Cys Glu Gln Ile Ala Ser Asp 
    690                 695                 700                 


Thr Cys His Leu Gln Arg Val Val Phe Lys Asn Ile Ser Pro Ala Asp 
705                 710                 715                 720 


Ala His Arg Asn Leu Cys Leu Ala Leu Arg Gly His Lys Thr Val Thr 
                725                 730                 735     


Tyr Leu Thr Leu Gln Gly Asn Asp Gln Asp Asp Met Phe Pro Ala Leu 
            740                 745                 750         


Cys Glu Val Leu Arg His Pro Glu Cys Asn Leu Arg Tyr Leu Gly Leu 
        755                 760                 765             


Val Ser Cys Ser Ala Thr Thr Gln Gln Trp Ala Asp Leu Ser Leu Ala 
    770                 775                 780                 


Leu Glu Val Asn Gln Ser Leu Thr Cys Val Asn Leu Ser Asp Asn Glu 
785                 790                 795                 800 


Leu Leu Asp Glu Gly Ala Lys Leu Leu Tyr Thr Thr Leu Arg His Pro 
                805                 810                 815     


Lys Cys Phe Leu Gln Arg Leu Ser Leu Glu Asn Cys His Leu Thr Glu 
            820                 825                 830         


Ala Asn Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Arg Glu Leu 
        835                 840                 845             


Thr His Leu Cys Leu Ala Lys Asn Pro Ile Gly Asn Thr Gly Val Lys 
    850                 855                 860                 


Phe Leu Cys Glu Gly Leu Arg Tyr Pro Glu Cys Lys Leu Gln Thr Leu 
865                 870                 875                 880 


Val Leu Trp Asn Cys Asp Ile Thr Ser Asp Gly Cys Cys Asp Leu Thr 
                885                 890                 895     


Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu Cys Leu Asp Leu Gly Leu 
            900                 905                 910         


Asn His Ile Gly Val Lys Gly Met Lys Phe Leu Cys Glu Ala Leu Arg 
        915                 920                 925             


Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp Leu Trp Gly Cys Ser Ile 
    930                 935                 940                 


Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser Ala Leu Ser Cys Asn Gln 
945                 950                 955                 960 


Ser Leu Val Thr Leu Asp Leu Gly Gln Asn Pro Leu Gly Ser Ser Gly 
                965                 970                 975     


Val Lys Met Leu Phe Glu Thr Leu Thr Cys Ser Ser Gly Thr Leu Arg 
            980                 985                 990         


Thr Leu Arg Leu Lys Ile Asp Asp  Phe Asn Asp Glu Leu  Asn Lys Leu 
        995                 1000                 1005             


Leu Glu  Glu Ile Glu Glu Lys  Asn Pro Gln Leu Ile  Ile Asp Thr 
    1010                 1015                 1020             


Glu Lys  His His Pro Trp Ala  Glu Arg Pro Ser Ser  His Asp Phe 
    1025                 1030                 1035             


Met Ile  
    1040 


<210> 5698
<211> 1287
<212> PRT
<213> Homo sapiens

<400> 5698
Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Ala Pro Leu 
1               5                   10                  15      


Asp His Thr Ser Asp Lys Ser Leu Leu Asp Ala Asn Phe Glu Pro Gly 
            20                  25                  30          


Lys Lys Asn Phe Leu His Leu Thr Asp Lys Asp Gly Glu Gln Pro Gln 
        35                  40                  45              


Ile Leu Leu Glu Asp Ser Ser Ala Gly Glu Asp Ser Val His Asp Arg 
    50                  55                  60                  


Phe Ile Gly Pro Leu Pro Arg Glu Gly Ser Gly Gly Ser Thr Ser Asp 
65                  70                  75                  80  


Tyr Val Ser Gln Ser Tyr Ser Tyr Ser Ser Ile Leu Asn Lys Ser Glu 
                85                  90                  95      


Thr Gly Tyr Val Gly Leu Val Asn Gln Ala Met Thr Cys Tyr Leu Asn 
            100                 105                 110         


Ser Leu Leu Gln Thr Leu Phe Met Thr Pro Glu Phe Arg Asn Ala Leu 
        115                 120                 125             


Tyr Lys Trp Glu Phe Glu Glu Ser Glu Glu Asp Pro Val Thr Ser Ile 
    130                 135                 140                 


Pro Tyr Gln Leu Gln Arg Leu Phe Val Leu Leu Gln Thr Ser Lys Lys 
145                 150                 155                 160 


Arg Ala Ile Glu Thr Thr Asp Val Thr Arg Ser Phe Gly Trp Asp Ser 
                165                 170                 175     


Ser Glu Ala Trp Gln Gln His Asp Val Gln Glu Leu Cys Arg Val Met 
            180                 185                 190         


Phe Asp Ala Leu Glu Gln Lys Trp Lys Gln Thr Glu Gln Ala Asp Leu 
        195                 200                 205             


Ile Asn Glu Leu Tyr Gln Gly Lys Leu Lys Asp Tyr Val Arg Cys Leu 
    210                 215                 220                 


Glu Cys Gly Tyr Glu Gly Trp Arg Ile Asp Thr Tyr Leu Asp Ile Pro 
225                 230                 235                 240 


Leu Val Ile Arg Pro Tyr Gly Ser Ser Gln Ala Phe Ala Ser Val Glu 
                245                 250                 255     


Glu Ala Leu His Ala Phe Ile Gln Pro Glu Ile Leu Asp Gly Pro Asn 
            260                 265                 270         


Gln Tyr Phe Cys Glu Arg Cys Lys Lys Lys Cys Asp Ala Arg Lys Gly 
        275                 280                 285             


Leu Arg Phe Leu His Phe Pro Tyr Leu Leu Thr Leu Gln Leu Lys Arg 
    290                 295                 300                 


Phe Asp Phe Asp Tyr Thr Thr Met His Arg Ile Lys Leu Asn Asp Arg 
305                 310                 315                 320 


Met Thr Phe Pro Glu Glu Leu Asp Met Ser Thr Phe Ile Asp Val Glu 
                325                 330                 335     


Asp Glu Lys Ser Pro Gln Thr Glu Ser Cys Thr Asp Ser Gly Ala Glu 
            340                 345                 350         


Asn Glu Gly Ser Cys His Ser Asp Gln Met Ser Asn Asp Phe Ser Asn 
        355                 360                 365             


Asp Asp Gly Val Asp Glu Gly Ile Cys Leu Glu Thr Asn Ser Gly Thr 
    370                 375                 380                 


Glu Lys Ile Ser Lys Ser Gly Leu Glu Lys Asn Ser Leu Ile Tyr Glu 
385                 390                 395                 400 


Leu Phe Ser Val Met Val His Ser Gly Ser Ala Ala Gly Gly His Tyr 
                405                 410                 415     


Tyr Ala Cys Ile Lys Ser Phe Ser Asp Glu Gln Trp Tyr Ser Phe Asn 
            420                 425                 430         


Asp Gln His Val Ser Arg Ile Thr Gln Glu Asp Ile Lys Lys Thr His 
        435                 440                 445             


Gly Gly Ser Ser Gly Ser Arg Gly Tyr Tyr Ser Ser Ala Phe Ala Ser 
    450                 455                 460                 


Ser Thr Asn Ala Tyr Met Leu Ile Tyr Arg Leu Lys Asp Pro Ala Arg 
465                 470                 475                 480 


Asn Ala Lys Phe Leu Glu Val Asp Glu Tyr Pro Glu His Ile Lys Asn 
                485                 490                 495     


Leu Val Gln Lys Glu Arg Glu Leu Glu Glu Gln Glu Lys Arg Gln Arg 
            500                 505                 510         


Glu Ile Glu Arg Asn Thr Cys Lys Ile Lys Leu Phe Cys Leu His Pro 
        515                 520                 525             


Thr Lys Gln Val Met Met Glu Asn Lys Leu Glu Val His Lys Asp Lys 
    530                 535                 540                 


Thr Leu Lys Glu Ala Val Glu Met Ala Tyr Lys Met Met Asp Leu Glu 
545                 550                 555                 560 


Glu Val Ile Pro Leu Asp Cys Cys Arg Leu Val Lys Tyr Asp Glu Phe 
                565                 570                 575     


His Asp Tyr Leu Glu Arg Ser Tyr Glu Gly Glu Glu Asp Thr Pro Met 
            580                 585                 590         


Gly Leu Leu Leu Gly Gly Val Lys Ser Thr Tyr Met Phe Asp Leu Leu 
        595                 600                 605             


Leu Glu Thr Arg Lys Pro Asp Gln Val Phe Gln Ser Tyr Lys Pro Gly 
    610                 615                 620                 


Glu Val Met Val Lys Val His Val Val Asp Leu Lys Ala Glu Ser Val 
625                 630                 635                 640 


Ala Ala Pro Ile Thr Val Arg Ala Tyr Leu Asn Gln Thr Val Thr Glu 
                645                 650                 655     


Phe Lys Gln Leu Ile Ser Lys Ala Ile His Leu Pro Ala Glu Thr Met 
            660                 665                 670         


Arg Ile Val Leu Glu Arg Cys Tyr Asn Asp Leu Arg Leu Leu Ser Val 
        675                 680                 685             


Ser Ser Lys Thr Leu Lys Ala Glu Gly Phe Phe Arg Ser Asn Lys Val 
    690                 695                 700                 


Phe Val Glu Ser Ser Glu Thr Leu Asp Tyr Gln Met Ala Phe Ala Asp 
705                 710                 715                 720 


Ser His Leu Trp Lys Leu Leu Asp Arg His Ala Asn Thr Ile Arg Leu 
                725                 730                 735     


Phe Val Leu Leu Pro Glu Gln Ser Pro Val Ser Tyr Ser Lys Arg Thr 
            740                 745                 750         


Ala Tyr Gln Lys Ala Gly Gly Asp Ser Gly Asn Val Asp Asp Asp Cys 
        755                 760                 765             


Glu Arg Val Lys Gly Pro Val Gly Ser Leu Lys Ser Val Glu Ala Ile 
    770                 775                 780                 


Leu Glu Glu Ser Thr Glu Lys Leu Lys Ser Leu Ser Leu Gln Gln Gln 
785                 790                 795                 800 


Gln Asp Gly Asp Asn Gly Asp Ser Ser Lys Ser Thr Glu Thr Ser Asp 
                805                 810                 815     


Phe Glu Asn Ile Glu Ser Pro Leu Asn Glu Arg Asp Ser Ser Ala Ser 
            820                 825                 830         


Val Asp Asn Arg Glu Leu Glu Gln His Ile Gln Thr Ser Asp Pro Glu 
        835                 840                 845             


Asn Phe Gln Ser Glu Glu Arg Ser Asp Ser Asp Val Asn Asn Asp Arg 
    850                 855                 860                 


Ser Thr Ser Ser Val Asp Ser Asp Ile Leu Ser Ser Ser His Ser Ser 
865                 870                 875                 880 


Asp Thr Leu Cys Asn Ala Asp Asn Ala Gln Ile Pro Leu Ala Asn Gly 
                885                 890                 895     


Leu Asp Ser His Ser Ile Thr Ser Ser Arg Arg Thr Lys Ala Asn Glu 
            900                 905                 910         


Gly Lys Lys Glu Thr Trp Asp Thr Ala Glu Glu Asp Ser Gly Thr Asp 
        915                 920                 925             


Ser Glu Tyr Asp Glu Ser Gly Lys Ser Arg Gly Glu Met Gln Tyr Met 
    930                 935                 940                 


Tyr Phe Lys Ala Glu Pro Tyr Ala Ala Asp Glu Gly Ser Gly Glu Gly 
945                 950                 955                 960 


His Lys Trp Leu Met Val His Val Asp Lys Arg Ile Thr Leu Ala Ala 
                965                 970                 975     


Phe Lys Gln His Leu Glu Pro Phe Val Gly Val Leu Ser Ser His Phe 
            980                 985                 990         


Lys Val Phe Arg Val Tyr Ala Ser  Asn Gln Glu Phe Glu  Ser Val Arg 
        995                 1000                 1005             


Leu Asn  Glu Thr Leu Ser Ser  Phe Ser Asp Asp Asn  Lys Ile Thr 
    1010                 1015                 1020             


Ile Arg  Leu Gly Arg Ala Leu  Lys Lys Gly Glu Tyr  Arg Val Lys 
    1025                 1030                 1035             


Val Tyr  Gln Leu Leu Val Asn  Glu Gln Glu Pro Cys  Lys Phe Leu 
    1040                 1045                 1050             


Leu Asp  Ala Val Phe Ala Lys  Gly Met Thr Val Arg  Gln Ser Lys 
    1055                 1060                 1065             


Glu Glu  Leu Ile Pro Gln Leu  Arg Glu Gln Cys Gly  Leu Glu Leu 
    1070                 1075                 1080             


Ser Ile  Asp Arg Phe Arg Leu  Arg Lys Lys Thr Trp  Lys Asn Pro 
    1085                 1090                 1095             


Gly Thr  Val Phe Leu Asp Tyr  His Ile Tyr Glu Glu  Asp Ile Asn 
    1100                 1105                 1110             


Ile Ser  Ser Asn Trp Glu Val  Phe Leu Glu Val Leu  Asp Gly Val 
    1115                 1120                 1125             


Glu Lys  Met Lys Ser Met Ser  Gln Leu Ala Val Leu  Ser Arg Arg 
    1130                 1135                 1140             


Trp Lys  Pro Ser Glu Met Lys  Leu Asp Pro Phe Gln  Glu Val Val 
    1145                 1150                 1155             


Leu Glu  Ser Ser Ser Val Asp  Glu Leu Arg Glu Lys  Leu Ser Glu 
    1160                 1165                 1170             


Ile Ser  Gly Ile Pro Leu Asp  Asp Ile Glu Phe Ala  Lys Gly Arg 
    1175                 1180                 1185             


Gly Thr  Phe Pro Cys Asp Ile  Ser Val Leu Asp Ile  His Gln Asp 
    1190                 1195                 1200             


Leu Asp  Trp Asn Pro Lys Val  Ser Thr Leu Asn Val  Trp Pro Leu 
    1205                 1210                 1215             


Tyr Ile  Cys Asp Asp Gly Ala  Val Ile Phe Tyr Arg  Asp Lys Thr 
    1220                 1225                 1230             


Glu Glu  Leu Met Glu Leu Thr  Asp Glu Gln Arg Asn  Glu Leu Met 
    1235                 1240                 1245             


Lys Lys  Glu Ser Ser Arg Leu  Gln Lys Thr Gly His  Arg Val Thr 
    1250                 1255                 1260             


Tyr Ser  Pro Arg Lys Glu Lys  Ala Leu Lys Ile Tyr  Leu Asp Gly 
    1265                 1270                 1275             


Ala Pro  Asn Lys Asp Leu Thr  Gln Asp 
    1280                 1285         


<210> 5699
<211> 139
<212> PRT
<213> Homo sapiens

<400> 5699
Met Pro Trp Arg Ala Gly Asn Gly Val Gly Leu Glu Ala Gln Ala Gly 
1               5                   10                  15      


Thr Gln Glu Ala Gly Pro Glu Glu Tyr Cys Gln Glu Glu Leu Gly Ala 
            20                  25                  30          


Glu Glu Glu Met Ala Ala Arg Ala Ala Trp Pro Val Leu Arg Ser Val 
        35                  40                  45              


Asn Ser Arg Glu Leu Ser Arg Ile Ile Ile Cys Asn His Ser Pro Arg 
    50                  55                  60                  


Ile Val Leu Pro Val Trp Leu Asn Tyr Tyr Gly Lys Leu Leu Pro Tyr 
65                  70                  75                  80  


Leu Thr Leu Leu Pro Gly Arg Asp Phe Arg Ile His Asn Phe Arg Ser 
                85                  90                  95      


His Pro Trp Leu Phe Arg Asp Ala Arg Thr His Asp Lys Leu Leu Val 
            100                 105                 110         


Asn Gln Thr Glu Leu Phe Val Pro Ser Ser Asn Val Asn Gly Gln Pro 
        115                 120                 125             


Val Phe Ala Asn Ile Thr Leu Gln Cys Ile Pro 
    130                 135                 


<210> 5700
<211> 193
<212> PRT
<213> Homo sapiens

<400> 5700
Met Glu Gly Cys Val Ser Asn Leu Met Val Cys Asn Leu Ala Tyr Ser 
1               5                   10                  15      


Gly Lys Leu Glu Glu Leu Lys Glu Ser Ile Leu Ala Asp Lys Ser Leu 
            20                  25                  30          


Ala Thr Arg Thr Asp Gln Ala Gly Trp Ser Pro Leu His Ile Ala Ala 
        35                  40                  45              


Ser Ala Gly Arg Asp Glu Ile Val Lys Ala Leu Leu Gly Lys Gly Ala 
    50                  55                  60                  


Gln Val Asn Ala Val Asn Gln Asn Gly Cys Thr Pro Leu His Tyr Ala 
65                  70                  75                  80  


Ala Ser Lys Asn Arg His Glu Ile Ala Val Met Leu Leu Glu Gly Gly 
                85                  90                  95      


Ala Asn Pro Asp Ala Lys Asp His Tyr Glu Ala Thr Ala Met His Arg 
            100                 105                 110         


Ala Ala Ala Lys Gly Asn Leu Lys Met Ile His Ile Leu Leu Tyr Tyr 
        115                 120                 125             


Lys Ala Ser Thr Asn Ile Gln Asp Thr Glu Gly Asn Thr Pro Leu His 
    130                 135                 140                 


Leu Ala Cys Asp Glu Glu Arg Val Glu Glu Ala Lys Leu Leu Val Ser 
145                 150                 155                 160 


Gln Gly Ala Ser Ile Tyr Ile Glu Asn Lys Glu Glu Lys Thr Pro Leu 
                165                 170                 175     


Gln Val Ala Lys Gly Gly Leu Gly Leu Ile Leu Lys Arg Met Val Glu 
            180                 185                 190         


Gly 
    


<210> 5701
<211> 203
<212> PRT
<213> Homo sapiens

<400> 5701
Met Ser Glu Asn Ala Ala Pro Gly Leu Ile Ser Glu Leu Lys Leu Ala 
1               5                   10                  15      


Val Pro Trp Gly His Ile Ala Ala Lys Ala Trp Gly Ser Leu Gln Gly 
            20                  25                  30          


Pro Pro Val Leu Cys Leu His Gly Trp Leu Asp Asn Ala Ser Ser Phe 
        35                  40                  45              


Asp Arg Leu Ile Pro Leu Leu Pro Gln Asp Phe Tyr Tyr Val Ala Met 
    50                  55                  60                  


Asp Phe Gly Gly His Gly Leu Ser Ser His Tyr Ser Pro Gly Val Pro 
65                  70                  75                  80  


Tyr Tyr Leu Gln Thr Phe Val Ser Glu Ile Arg Arg Val Val Ala Ala 
                85                  90                  95      


Leu Lys Trp Asn Arg Phe Ser Ile Leu Gly His Ser Phe Gly Gly Val 
            100                 105                 110         


Val Gly Gly Met Phe Phe Cys Thr Phe Pro Glu Met Val Asp Lys Leu 
        115                 120                 125             


Ile Leu Leu Asp Thr Pro Leu Phe Leu Leu Glu Ser Asp Glu Met Glu 
    130                 135                 140                 


Asn Leu Leu Thr Tyr Lys Arg Arg Ala Ile Glu His Val Leu Gln Val 
145                 150                 155                 160 


Glu Ala Ser Gln Glu Pro Ser His Val Phe Ser Leu Lys Gln Leu Leu 
                165                 170                 175     


Gln Arg Gln Arg Thr Ala Leu Thr Ser Ser Ala Gly Ser Cys Val Arg 
            180                 185                 190         


Ile Pro Ser Gly Ser Cys Arg Pro Met Ser Cys 
        195                 200             


<210> 5702
<211> 254
<212> PRT
<213> Homo sapiens

<400> 5702
Met Pro Ala Gly Ser Met Ser Thr Thr Gly Tyr Pro Gly Val Cys Ser 
1               5                   10                  15      


Thr Thr Ser Tyr Arg Thr His Cys Tyr Ile Pro Val Thr Ser Ser Val 
            20                  25                  30          


Thr Leu Ser Ser Ser Asp Leu Ser Pro Thr Phe Gly His Cys Leu Pro 
        35                  40                  45              


Ser Ser Tyr Gln Gly Asn Leu Trp Leu Leu Asp Tyr Cys Gln Glu Ser 
    50                  55                  60                  


Tyr Gly Glu Ala Pro Thr Cys Lys Ser Pro Ser Cys Glu Pro Lys Thr 
65                  70                  75                  80  


Cys Ser Thr Thr Gly Cys Asp Pro Ser Asn Ser Ser Val Pro Cys Asn 
                85                  90                  95      


Ser Pro Ser Ala Gly Gln Val Phe Ser Val Cys Glu Thr Thr Asn Val 
            100                 105                 110         


Ser Pro Ser Pro Ser Cys Ser Pro Ser Thr Gln Thr Asn Gly Tyr Val 
        115                 120                 125             


Cys Asn Cys His Ile Pro Thr Arg Asn Ala Ser Lys Ala Cys Gln Thr 
    130                 135                 140                 


Leu Arg Asn Gly Ser Asn Cys Phe Gly Gln Leu Asn Cys Leu Ser Lys 
145                 150                 155                 160 


Ser Phe Gln Thr Leu Asn His Cys Arg Leu Ser Thr Leu Gly Tyr Lys 
                165                 170                 175     


Ser Tyr Gln Asn Pro Cys Phe Ile Pro Ser Tyr Val Ser Pro Leu Cys 
            180                 185                 190         


Tyr Ile Ser Asn Ser Cys Gln Pro Gln Ser Tyr Leu Val Arg Asn Tyr 
        195                 200                 205             


His Tyr Ser Ser Tyr Arg Pro Thr Ser Cys Arg Pro Leu Ser Tyr Leu 
    210                 215                 220                 


Ser Arg Ser Phe Arg Ser Leu Ser Tyr Ile Pro Ser Thr Phe Pro Pro 
225                 230                 235                 240 


Leu Arg Tyr Leu Cys Ser Gly Ser Arg Pro Leu Lys Cys Tyr 
                245                 250                 


<210> 5703
<211> 445
<212> PRT
<213> Homo sapiens

<400> 5703
Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 445 


<210> 5704
<211> 249
<212> PRT
<213> Homo sapiens

<400> 5704
Met Ala Glu Arg Gly Glu Leu Asp Leu Thr Gly Ala Lys Gln Asn Thr 
1               5                   10                  15      


Gly Val Trp Leu Val Lys Val Pro Lys Tyr Leu Ser Gln Gln Trp Ala 
            20                  25                  30          


Lys Ala Ser Gly Arg Gly Glu Val Gly Lys Leu Arg Ile Ala Lys Thr 
        35                  40                  45              


Gln Gly Arg Thr Glu Val Ser Phe Thr Leu Asn Glu Asp Leu Ala Asn 
    50                  55                  60                  


Ile His Asp Ile Gly Gly Lys Pro Ala Ser Val Ser Ala Pro Arg Glu 
65                  70                  75                  80  


His Pro Phe Val Leu Gln Ser Val Gly Gly Gln Thr Leu Thr Val Phe 
                85                  90                  95      


Thr Glu Ser Ser Ser Asp Lys Leu Ser Leu Glu Gly Ile Val Val Gln 
            100                 105                 110         


Arg Ala Glu Cys Arg Pro Ala Ala Ser Glu Asn Tyr Met Arg Leu Lys 
        115                 120                 125             


Arg Leu Gln Ile Glu Glu Ser Ser Lys Pro Val Arg Leu Ser Gln Gln 
    130                 135                 140                 


Leu Asp Lys Val Val Thr Thr Asn Tyr Lys Pro Val Ala Asn His Gln 
145                 150                 155                 160 


Tyr Asn Ile Glu Tyr Glu Arg Lys Lys Lys Glu Asp Gly Lys Arg Ala 
                165                 170                 175     


Arg Ala Asp Lys Gln His Val Leu Asp Met Leu Phe Ser Ala Phe Glu 
            180                 185                 190         


Lys His Gln Tyr Tyr Asn Leu Lys Asp Leu Val Asp Ile Thr Lys Gln 
        195                 200                 205             


Pro Val Val Tyr Leu Lys Glu Ile Leu Lys Glu Ile Gly Val Gln Asn 
    210                 215                 220                 


Val Lys Gly Ile His Lys Asn Thr Trp Glu Leu Lys Pro Glu Tyr Arg 
225                 230                 235                 240 


His Tyr Gln Gly Glu Glu Lys Ser Asp 
                245                 


<210> 5705
<211> 836
<212> PRT
<213> Homo sapiens

<400> 5705
Met Trp Ser Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro 
1               5                   10                  15      


Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln 
            20                  25                  30          


Thr Gln Gly Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr 
        35                  40                  45              


Thr Arg Phe Phe Asn Arg Asp Pro Asn Leu Gly Tyr Pro Leu Trp Arg 
    50                  55                  60                  


Leu Lys Thr Pro Glu Glu His Glu Leu Glu Thr Gly Ile Lys Ser Lys 
65                  70                  75                  80  


Glu Ala Arg Lys Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val 
                85                  90                  95      


Asn Met Ser Thr Asp Leu Glu Gly Thr Asp Met Leu Ala Glu Lys Ala 
            100                 105                 110         


Asp Arg Arg Glu Tyr Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp 
        115                 120                 125             


Ala Asp Lys Arg Ile Thr Pro Leu Lys Thr Leu Asn His Gln Phe Val 
    130                 135                 140                 


Thr Met Thr His Leu Leu Asp Phe Pro His Ser Asn His Val Lys Ser 
145                 150                 155                 160 


Cys Phe Gln Asn Met Glu Ile Cys Lys Arg Arg Val His Met Tyr Asp 
                165                 170                 175     


Thr Val Ser Gln Ile Lys Ser Pro Phe Thr Thr His Val Ala Pro Asn 
            180                 185                 190         


Thr Ser Thr Asn Leu Thr Met Ser Phe Ser Asn Gln Leu Asn Thr Val 
        195                 200                 205             


His Asn Gln Ala Ser Val Leu Ala Ser Ser Ser Thr Ala Ala Ala Ala 
    210                 215                 220                 


Thr Leu Ser Leu Ala Asn Ser Asp Val Ser Leu Leu Asn Tyr Gln Ser 
225                 230                 235                 240 


Ala Leu Tyr Pro Ser Ser Ala Ala Pro Val Pro Gly Val Ala Gln Gln 
                245                 250                 255     


Gly Val Ser Leu Gln Pro Gly Thr Thr Gln Ile Cys Thr Gln Thr Asp 
            260                 265                 270         


Pro Phe Gln Gln Thr Phe Ile Val Cys Pro Pro Ala Phe Gln Thr Gly 
        275                 280                 285             


Leu Gln Ala Thr Thr Lys His Ser Gly Phe Pro Val Arg Met Asp Asn 
    290                 295                 300                 


Ala Val Pro Ile Val Pro Gln Ala Pro Ala Ala Gln Pro Leu Gln Ile 
305                 310                 315                 320 


Gln Ser Gly Val Leu Thr Gln Gly Ser Cys Thr Pro Leu Met Val Ala 
                325                 330                 335     


Thr Leu His Pro Gln Val Ala Thr Ile Thr Pro Gln Tyr Ala Val Pro 
            340                 345                 350         


Phe Thr Leu Ser Cys Ala Ala Gly Arg Pro Ala Leu Val Glu Gln Thr 
        355                 360                 365             


Ala Ala Val Leu Gln Ala Trp Pro Gly Gly Thr Gln Gln Ile Leu Leu 
    370                 375                 380                 


Pro Ser Thr Trp Gln Gln Leu Pro Gly Val Ala Leu His Asn Ser Val 
385                 390                 395                 400 


Gln Pro Thr Ala Met Ile Pro Glu Ala Met Gly Ser Gly Gln Gln Leu 
                405                 410                 415     


Ala Asp Trp Arg Asn Ala His Ser His Gly Asn Gln Tyr Ser Thr Ile 
            420                 425                 430         


Met Gln Gln Pro Ser Leu Leu Thr Asn His Val Thr Leu Ala Thr Ala 
        435                 440                 445             


Gln Pro Leu Asn Val Gly Val Ala His Val Val Arg Gln Gln Gln Ser 
    450                 455                 460                 


Ser Ser Leu Pro Ser Lys Lys Asn Lys Gln Ser Ala Pro Val Ser Ser 
465                 470                 475                 480 


Lys Ser Ser Leu Asp Val Leu Pro Ser Gln Val Tyr Ser Leu Val Gly 
                485                 490                 495     


Ser Ser Pro Leu Arg Thr Thr Ser Ser Tyr Asn Ser Leu Val Pro Val 
            500                 505                 510         


Gln Asp Gln His Gln Pro Ile Ile Ile Pro Asp Thr Pro Ser Pro Pro 
        515                 520                 525             


Val Ser Val Ile Thr Ile Arg Ser Asp Thr Asp Glu Glu Glu Asp Asn 
    530                 535                 540                 


Lys Tyr Lys Pro Ser Ser Ser Gly Leu Lys Pro Arg Ser Asn Val Ile 
545                 550                 555                 560 


Ser Tyr Val Thr Val Asn Asp Ser Pro Asp Ser Asp Ser Ser Leu Ser 
                565                 570                 575     


Ser Pro Tyr Ser Thr Asp Thr Leu Ser Ala Leu Arg Gly Asn Ser Gly 
            580                 585                 590         


Ser Val Leu Glu Gly Pro Gly Arg Val Val Ala Asp Gly Thr Gly Thr 
        595                 600                 605             


Arg Thr Ile Ile Val Pro Pro Leu Lys Thr Gln Leu Gly Asp Cys Thr 
    610                 615                 620                 


Val Ala Thr Gln Ala Ser Gly Leu Leu Ser Asn Lys Thr Lys Pro Val 
625                 630                 635                 640 


Ala Ser Val Ser Gly Gln Ser Ser Gly Cys Cys Ile Thr Pro Thr Gly 
                645                 650                 655     


Tyr Arg Ala Gln Arg Gly Gly Thr Ser Ala Ala Gln Pro Leu Asn Leu 
            660                 665                 670         


Ser Gln Asn Gln Gln Ser Ser Ala Ala Pro Thr Ser Gln Glu Arg Ser 
        675                 680                 685             


Ser Asn Pro Ala Pro Arg Arg Gln Gln Ala Phe Val Ala Pro Leu Ser 
    690                 695                 700                 


Gln Ala Pro Tyr Thr Phe Gln His Gly Ser Pro Leu His Ser Thr Gly 
705                 710                 715                 720 


His Pro His Leu Ala Pro Ala Pro Ala His Leu Pro Ser Gln Ala His 
                725                 730                 735     


Leu Tyr Thr Tyr Ala Ala Pro Thr Ser Ala Ala Ala Leu Gly Ser Thr 
            740                 745                 750         


Ser Ser Ile Ala His Leu Phe Ser Pro Gln Gly Ser Ser Arg His Ala 
        755                 760                 765             


Ala Ala Tyr Thr Thr His Pro Ser Thr Leu Val His Gln Val Pro Val 
    770                 775                 780                 


Ser Val Gly Pro Ser Leu Leu Thr Ser Ala Ser Val Ala Pro Ala Gln 
785                 790                 795                 800 


Tyr Gln His Gln Phe Ala Thr Gln Ser Tyr Ile Gly Ser Ser Arg Gly 
                805                 810                 815     


Ser Thr Ile Tyr Thr Gly Tyr Pro Leu Ser Pro Thr Lys Ile Ser Gln 
            820                 825                 830         


Tyr Ser Tyr Leu 
        835     


<210> 5706
<211> 783
<212> PRT
<213> Homo sapiens

<400> 5706
Met Ser Gln Val Lys Ser Ser Tyr Ser Tyr Asp Ala Pro Ser Asp Phe 
1               5                   10                  15      


Ile Asn Phe Ser Ser Leu Asp Asp Glu Gly Asp Thr Gln Asn Ile Asp 
            20                  25                  30          


Ser Trp Phe Glu Glu Lys Ala Asn Leu Glu Asn Lys Leu Leu Gly Lys 
        35                  40                  45              


Asn Gly Thr Gly Gly Leu Phe Gln Gly Lys Thr Pro Leu Arg Lys Ala 
    50                  55                  60                  


Asn Leu Gln Gln Ala Ile Val Thr Pro Leu Lys Pro Val Asp Asn Thr 
65                  70                  75                  80  


Tyr Tyr Lys Glu Ala Glu Lys Glu Asn Leu Val Glu Gln Ser Ile Pro 
                85                  90                  95      


Ser Asn Ala Cys Ser Ser Leu Glu Val Glu Ala Ala Ile Ser Arg Lys 
            100                 105                 110         


Thr Pro Ala Gln Pro Gln Arg Arg Ser Leu Arg Leu Ser Ala Gln Lys 
        115                 120                 125             


Asp Leu Glu Gln Lys Glu Lys His His Val Lys Met Lys Ala Lys Arg 
    130                 135                 140                 


Cys Ala Thr Pro Val Ile Ile Asp Glu Ile Leu Pro Ser Lys Lys Met 
145                 150                 155                 160 


Lys Val Ser Asn Asn Lys Lys Lys Pro Glu Glu Glu Gly Ser Ala His 
                165                 170                 175     


Gln Asp Thr Ala Glu Lys Asn Ala Ser Ser Pro Glu Lys Ala Lys Gly 
            180                 185                 190         


Arg His Thr Val Pro Cys Met Pro Pro Ala Lys Gln Lys Phe Leu Lys 
        195                 200                 205             


Ser Thr Glu Glu Gln Glu Leu Glu Lys Ser Met Lys Met Gln Gln Glu 
    210                 215                 220                 


Val Val Glu Met Arg Lys Lys Asn Glu Glu Phe Lys Lys Leu Ala Leu 
225                 230                 235                 240 


Ala Gly Ile Gly Gln Pro Val Lys Lys Ser Val Ser Gln Val Thr Lys 
                245                 250                 255     


Ser Val Asp Phe His Phe Arg Thr Asp Glu Arg Ile Lys Gln His Pro 
            260                 265                 270         


Lys Asn Gln Glu Glu Tyr Lys Glu Val Asn Phe Thr Ser Glu Leu Arg 
        275                 280                 285             


Lys His Pro Ser Ser Pro Ala Arg Val Thr Lys Gly Cys Thr Ile Val 
    290                 295                 300                 


Lys Pro Phe Asn Leu Ser Gln Gly Lys Lys Arg Thr Phe Asp Glu Thr 
305                 310                 315                 320 


Val Ser Thr Tyr Val Pro Leu Ala Gln Gln Val Glu Asp Phe His Lys 
                325                 330                 335     


Arg Thr Pro Asn Arg Tyr His Leu Arg Ser Lys Lys Asp Asp Ile Lys 
            340                 345                 350         


Thr Gly Ser Cys Ser Val Thr Gln Ala Gly Val Gln Trp Arg Asp His 
        355                 360                 365             


Gly Ser Leu Gln Cys Pro Thr Pro Gly Leu Lys Gln Ser Ser Cys Leu 
    370                 375                 380                 


Ser Leu Pro Asn Leu Leu Pro Ser Lys Ser Ser Val Thr Lys Ile Cys 
385                 390                 395                 400 


Arg Asp Pro Gln Thr Pro Val Leu Gln Thr Lys His Arg Ala Arg Ala 
                405                 410                 415     


Val Thr Cys Lys Ser Thr Ala Glu Leu Glu Ala Glu Glu Leu Glu Lys 
            420                 425                 430         


Leu Gln Gln Tyr Lys Phe Lys Ala Arg Glu Leu Asp Pro Arg Ile Leu 
        435                 440                 445             


Glu Gly Gly Pro Ile Leu Pro Lys Lys Pro Pro Val Lys Pro Pro Thr 
    450                 455                 460                 


Glu Pro Ile Gly Phe Asp Leu Glu Ile Glu Lys Arg Ile Gln Glu Arg 
465                 470                 475                 480 


Glu Ser Lys Lys Lys Thr Glu Asp Glu His Phe Glu Phe His Ser Arg 
                485                 490                 495     


Pro Cys Pro Thr Lys Ile Leu Glu Asp Val Val Gly Val Pro Glu Lys 
            500                 505                 510         


Lys Val Leu Pro Ile Thr Val Pro Lys Ser Pro Ala Phe Ala Leu Lys 
        515                 520                 525             


Asn Arg Ile Arg Met Pro Thr Lys Glu Asp Glu Glu Glu Asp Glu Pro 
    530                 535                 540                 


Val Val Ile Lys Ala Gln Pro Val Pro His Tyr Gly Val Pro Phe Lys 
545                 550                 555                 560 


Pro Gln Ile Pro Glu Ala Arg Thr Val Glu Ile Cys Pro Phe Ser Phe 
                565                 570                 575     


Asp Ser Arg Asp Lys Glu Arg Gln Leu Gln Lys Glu Lys Lys Ile Lys 
            580                 585                 590         


Glu Leu Gln Lys Gly Glu Val Pro Lys Phe Lys Ala Leu Pro Leu Pro 
        595                 600                 605             


His Phe Asp Thr Ile Asn Leu Pro Glu Lys Lys Val Lys Asn Val Thr 
    610                 615                 620                 


Gln Ile Glu Pro Phe Cys Leu Glu Thr Asp Arg Arg Gly Ala Leu Lys 
625                 630                 635                 640 


Ala Gln Thr Trp Lys His Gln Leu Glu Glu Glu Leu Arg Gln Gln Lys 
                645                 650                 655     


Glu Ala Ala Cys Phe Lys Ala Arg Pro Asn Thr Val Ile Ser Gln Glu 
            660                 665                 670         


Pro Phe Val Pro Lys Lys Glu Lys Lys Ser Val Ala Glu Gly Leu Ser 
        675                 680                 685             


Gly Ser Leu Val Gln Glu Pro Phe Gln Leu Ala Thr Glu Lys Arg Ala 
    690                 695                 700                 


Lys Glu Arg Gln Glu Leu Glu Lys Arg Met Ala Glu Val Glu Ala Gln 
705                 710                 715                 720 


Lys Ala Gln Gln Leu Glu Glu Ala Arg Leu Gln Glu Glu Glu Gln Lys 
                725                 730                 735     


Lys Glu Glu Leu Ala Arg Leu Arg Arg Glu Leu Val His Lys Ala Asn 
            740                 745                 750         


Pro Ile Arg Lys Tyr Gln Gly Leu Glu Ile Lys Ser Ser Asp Gln Pro 
        755                 760                 765             


Leu Thr Val Pro Val Ser Pro Lys Phe Ser Thr Arg Phe His Cys 
    770                 775                 780             


<210> 5707
<211> 686
<212> PRT
<213> Homo sapiens

<400> 5707
Met Gly Ser Tyr Leu Ser Val Pro Ala Tyr Phe Thr Ser Arg Asp Leu 
1               5                   10                  15      


Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr Asn Trp Tyr Tyr Glu 
            20                  25                  30          


Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr Trp Gly Lys Phe Gly 
        35                  40                  45              


Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr Gly Pro Phe Met Val 
    50                  55                  60                  


Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe Ala Cys Met Ser Cys 
65                  70                  75                  80  


Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala Leu Val Gln His Ala 
                85                  90                  95      


Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val Val Leu Ala Pro Met 
            100                 105                 110         


Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu Gln Leu Pro Tyr Ser 
        115                 120                 125             


Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu Gly Arg Arg Gly Phe 
    130                 135                 140                 


Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr Ala Thr Thr Val Gln 
145                 150                 155                 160 


Val Lys Glu Val Asn Arg Met His Ile Ser Pro Asn Asn Arg Asn Ala 
                165                 170                 175     


Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn Gly Thr Pro Val Arg 
            180                 185                 190         


Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile Ser Gln Thr Ser Gln 
        195                 200                 205             


Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val Ser Gln Arg Leu Asp 
    210                 215                 220                 


Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His Met Gln Asn Ala Gly 
225                 230                 235                 240 


His Pro His Ala Leu Ser Thr Leu Asp Thr Lys Glu Asn Leu Glu Gly 
                245                 250                 255     


Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn Ser Ile Ser Lys Ser 
            260                 265                 270         


Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu Phe Ser Arg Asp Ile 
        275                 280                 285             


Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser Tyr Ser Gln Gln Ile 
    290                 295                 300                 


Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Phe 
305                 310                 315                 320 


Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala Thr Gly Lys Val Met 
                325                 330                 335     


Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu Thr Gln Lys Thr Phe 
            340                 345                 350         


Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp His Pro Asn Val Leu 
        355                 360                 365             


Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys Leu Asn Leu Leu Thr 
    370                 375                 380                 


Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe Leu Arg Ser Met Asp 
385                 390                 395                 400 


Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala Lys Gly Ile Ala Ser 
                405                 410                 415     


Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile His Arg Asp Leu Asn 
            420                 425                 430         


Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr Val Val Val Ala Asp 
        435                 440                 445             


Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg Lys Arg Ala Pro Met 
    450                 455                 460                 


Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg Lys Asn Asp Arg Lys 
465                 470                 475                 480 


Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp Met Ala Pro Glu Met 
                485                 490                 495     


Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp Ile Phe Ser Phe Gly 
            500                 505                 510         


Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr Ala Asp Pro Asp Cys 
        515                 520                 525             


Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val Lys Leu Phe Trp Glu 
    530                 535                 540                 


Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe Phe Pro Leu Ala Ala 
545                 550                 555                 560 


Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Ala Pro Pro Gly Ala Ala 
                565                 570                 575     


Gly Glu Gly Pro Gly Cys Ala Asp Asp Glu Gly Pro Val Arg Arg Gln 
            580                 585                 590         


Gly Lys Val Thr Ile Lys Tyr Asp Pro Lys Glu Leu Arg Lys His Leu 
        595                 600                 605             


Asn Leu Glu Glu Trp Ile Leu Glu Gln Leu Thr Arg Leu Tyr Asp Cys 
    610                 615                 620                 


Gln Glu Glu Glu Ile Ser Glu Leu Glu Ile Asp Val Asp Glu Leu Leu 
625                 630                 635                 640 


Asp Met Glu Ser Asp Asp Ala Trp Ala Ser Arg Val Lys Glu Leu Leu 
                645                 650                 655     


Val Asp Cys Tyr Lys Pro Thr Glu Ala Phe Ile Ser Gly Leu Leu Asp 
            660                 665                 670         


Lys Ile Arg Ala Met Gln Lys Leu Ser Thr Pro Gln Lys Lys 
        675                 680                 685     


<210> 5708
<211> 279
<212> PRT
<213> Homo sapiens

<400> 5708
Met Arg Ala Leu Thr Val Gln Arg Val Lys Phe Ala Met Asp Leu Pro 
1               5                   10                  15      


Leu Leu Lys Arg Ala Gly Gln Asp Leu Ala Glu Lys Thr Lys Asn Phe 
            20                  25                  30          


Val Ser Arg Ser Leu Val Ile Gly Glu Val Leu Ser Met Ala Asp Met 
        35                  40                  45              


Ala Thr Gly Val Lys Cys Gly Ile Ile Tyr Trp Leu Phe Gly Gly Ala 
    50                  55                  60                  


Ile Arg Asn Leu Gly Ser Pro Glu His Val Thr Lys Trp Phe Gln Pro 
65                  70                  75                  80  


Leu Gln Glu Gln Lys Tyr Thr Gly Met Phe Ala Met Thr Glu Arg Gly 
                85                  90                  95      


His Gly Ser Asn Ala Arg Gly Ile Gln Thr Glu Ala Thr Phe Asp Leu 
            100                 105                 110         


Ser Ala Gln Glu Phe Val Ile Asp Thr Pro Cys Glu Asn Ala Glu Lys 
        115                 120                 125             


Met Tyr Ile Gly Asn Ala Met Tyr Gly Asn Tyr Ala Ala Val Phe Ala 
    130                 135                 140                 


Gln Leu Ile Ile Asp Gly Arg Ser Gln Gly Pro His Cys Phe Ile Val 
145                 150                 155                 160 


Pro Val Arg Asp Glu Asn Gly Ser Leu Tyr Pro Gly Val Thr Ala Ile 
                165                 170                 175     


Asp Met Met Tyr Lys Glu Gly Leu His Gly Val Asp Asn Gly Ile Leu 
            180                 185                 190         


Ile Phe Asp Lys Val Arg Ile Pro Arg Glu Asn Leu Leu Asp Lys Phe 
        195                 200                 205             


Gly Ser Val Ala Pro Asp Gly Gln Tyr His Ser Pro Ile Arg Asn Lys 
    210                 215                 220                 


Ser Ala Arg Phe Asn Ala Met Leu Ala Ala Leu Thr Pro Ser Arg Leu 
225                 230                 235                 240 


Ala Val Ala Phe Gln Ala Met Gly Ala Met Lys Leu Gly Leu Thr Ile 
                245                 250                 255     


Ala Ile Arg Tyr Ser His Arg Ser Arg Ile Ile Ser Gln Asn Cys Cys 
            260                 265                 270         


Ser Ala Pro Ala Gly Leu Tyr 
        275                 


<210> 5709
<211> 198
<212> PRT
<213> Homo sapiens

<400> 5709
Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210> 5710
<211> 189
<212> PRT
<213> Homo sapiens

<400> 5710
Met Glu Ala Asp Gly Asp Gly Glu Glu Leu Ala Arg Leu Arg Ser Val 
1               5                   10                  15      


Phe Ala Ala Cys Asp Ala Asn Arg Ser Gly Arg Leu Glu Arg Glu Glu 
            20                  25                  30          


Phe Arg Ala Leu Cys Thr Glu Leu Arg Val Arg Pro Ala Asp Ala Glu 
        35                  40                  45              


Ala Val Phe Gln Arg Leu Asp Ala Asp Arg Asp Gly Ala Ile Thr Phe 
    50                  55                  60                  


Gln Glu Phe Ala Arg Gly Phe Leu Gly Ser Leu Arg Gly Gly Arg Arg 
65                  70                  75                  80  


Arg Asp Trp Gly Pro Leu Asp Pro Ala Pro Ala Val Ser Glu Ala Gly 
                85                  90                  95      


Pro Glu Thr His Asp Ser Glu Glu Asp Glu Gly Asp Glu Asp Ala Ala 
            100                 105                 110         


Ala Ala Leu Ala Thr Ser Cys Gly Pro Ala Ser Pro Gly Arg Ala Trp 
        115                 120                 125             


Gln Asp Phe Gln Ala Arg Leu Gly Asp Glu Ala Lys Phe Ile Pro Arg 
    130                 135                 140                 


Phe Gly Tyr Thr Ile Ser Lys Pro Ala Phe Val Phe Val Arg His Leu 
145                 150                 155                 160 


Ile Thr Leu Cys Ala Leu Ser Trp Ala Lys Lys Glu Gly Arg Glu Thr 
                165                 170                 175     


Leu Trp Thr Ile Glu Glu Gly Gly Ala Lys Met Ala Glu 
            180                 185                 


<210> 5711
<211> 99
<212> PRT
<213> Homo sapiens

<400> 5711
Ala Leu Asp Val Ala Val Lys Thr Phe Pro Pro Glu Arg His Val Ala 
1               5                   10                  15      


Val Lys Cys Phe Gly Lys Lys Lys Glu Lys Lys Asn Asn Ala Asn Ser 
            20                  25                  30          


Pro Ala Ser Val Ser Asn Pro Thr Val Thr Lys His Ala Phe Gly Met 
        35                  40                  45              


Glu Glu Glu Leu Gln Arg Glu Gly Ser Ile Glu Thr Leu Ser Asn Ser 
    50                  55                  60                  


Ser Gly Ser Thr Ser Gly Ser Ile Pro Arg Asn Phe Asp Gly Tyr Arg 
65                  70                  75                  80  


Ser Pro Leu Pro Thr Asn Glu Ser Gln Pro Leu Ser Leu Phe Pro Thr 
                85                  90                  95      


Gly Phe Pro 
            


<210> 5712
<211> 389
<212> PRT
<213> Homo sapiens

<400> 5712
Met Glu Arg Lys Asp Phe Glu Thr Trp Leu Asp Asn Ile Ser Val Thr 
1               5                   10                  15      


Phe Leu Ser Leu Thr Asp Leu Gln Lys Asn Glu Thr Leu Asp His Leu 
            20                  25                  30          


Ile Ser Leu Ser Gly Ala Val Gln Leu Arg His Leu Ser Asn Asn Leu 
        35                  40                  45              


Glu Thr Leu Leu Lys Arg Asp Phe Leu Lys Leu Leu Pro Leu Glu Leu 
    50                  55                  60                  


Ser Phe Tyr Leu Leu Lys Trp Leu Asp Pro Gln Thr Leu Leu Thr Cys 
65                  70                  75                  80  


Cys Leu Val Ser Lys Gln Trp Asn Lys Val Ile Ser Ala Cys Thr Glu 
                85                  90                  95      


Val Trp Gln Thr Ala Cys Lys Asn Leu Gly Trp Gln Ile Asp Asp Ser 
            100                 105                 110         


Val Gln Asp Ala Leu His Trp Lys Lys Val Tyr Leu Lys Ala Ile Leu 
        115                 120                 125             


Arg Met Lys Gln Leu Glu Asp His Glu Ala Phe Glu Thr Ser Ser Leu 
    130                 135                 140                 


Ile Gly His Ser Ala Arg Val Tyr Ala Leu Tyr Tyr Lys Asp Gly Leu 
145                 150                 155                 160 


Leu Cys Thr Val Phe Ser Val Asp Tyr Asn Asp Glu Leu Asp Ile Leu 
                165                 170                 175     


Val Ser Gly Ser Ala Asp Phe Thr Val Lys Val Trp Ala Leu Ser Ala 
            180                 185                 190         


Gly Thr Cys Leu Asn Thr Leu Thr Gly His Thr Glu Trp Val Thr Lys 
        195                 200                 205             


Val Val Leu Gln Lys Cys Lys Val Lys Ser Leu Leu His Ser Pro Gly 
    210                 215                 220                 


Asp Tyr Ile Leu Leu Ser Ala Asp Lys Tyr Glu Ile Lys Ile Trp Pro 
225                 230                 235                 240 


Ile Gly Arg Glu Ile Asn Cys Lys Cys Leu Lys Thr Leu Ser Val Ser 
                245                 250                 255     


Glu Asp Arg Ser Ile Cys Leu Gln Pro Arg Leu His Phe Asp Gly Lys 
            260                 265                 270         


Tyr Ile Val Cys Ser Ser Ala Leu Gly Leu Tyr Gln Trp Asp Phe Ala 
        275                 280                 285             


Ser Tyr Asp Ile Leu Arg Val Ile Lys Thr Pro Glu Ile Ala Asn Leu 
    290                 295                 300                 


Ala Leu Leu Gly Phe Gly Asp Ile Phe Ala Leu Leu Phe Asp Asn Arg 
305                 310                 315                 320 


Tyr Leu Tyr Ile Met Asp Leu Arg Thr Glu Ser Leu Ile Ser Arg Trp 
                325                 330                 335     


Pro Leu Pro Glu Tyr Arg Lys Ser Lys Arg Gly Ser Ser Phe Leu Ala 
            340                 345                 350         


Gly Glu Ala Ser Trp Leu Asn Gly Leu Asp Gly His Asn Asp Thr Gly 
        355                 360                 365             


Leu Val Phe Ala Thr Ser Met Pro Asp His Ser Ile His Leu Val Leu 
    370                 375                 380                 


Trp Lys Glu His Gly 
385                 


<210> 5713
<211> 812
<212> PRT
<213> Homo sapiens

<400> 5713
Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Thr Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Thr Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Thr His Lys 
        35                  40                  45              


Lys Leu Thr Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Thr Thr Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Thr Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Thr Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Thr Arg Trp Gln Gln Thr Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Thr Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Thr Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Thr Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Thr Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Thr Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Thr Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Thr Glu Met Met Thr Thr Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Thr Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Thr 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Met Gly Val Arg 
            500                 505                 510         


Val Met Asp Thr Asn Trp Val Ala Arg Arg Gly Ser Ser Ala Gly Arg 
        515                 520                 525             


Lys Val Ser Cys Ala Pro Pro Ser Met Gln Pro Pro Ala Pro Pro Ala 
    530                 535                 540                 


Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu Pro Glu Gln Pro Leu Asp 
545                 550                 555                 560 


Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser Gly Leu Gly Leu Gln Pro 
                565                 570                 575     


Gly Pro Glu Arg Thr Ser Thr Thr Lys Ser Lys Glu Leu Ser Pro Gly 
            580                 585                 590         


Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser Gln Gly Thr Ala Cys Ala 
        595                 600                 605             


Gly Thr Gln Pro Gly Ala Gln Pro Gly Ala Gln Pro Gly Ala Ser Pro 
    610                 615                 620                 


Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser Pro His Thr Leu Arg Lys 
625                 630                 635                 640 


Val Ser Lys Lys Leu Ala Pro Ile Pro Pro Lys Val Pro Phe Gly Gln 
                645                 650                 655     


Pro Gly Ala Met Ala Asp Gln Ser Ala Gly Gln Pro Ser Pro Val Ser 
            660                 665                 670         


Leu Ser Pro Thr Pro Pro Ser Thr Pro Ser Pro Tyr Gly Leu Ser Tyr 
        675                 680                 685             


Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln Leu Ser Pro Ala Ala Ala 
    690                 695                 700                 


Pro Pro Leu Ala Ser Pro Ser Val Phe Thr Ser Thr Leu Ser Lys Ser 
705                 710                 715                 720 


Arg Pro Thr Pro Lys Pro Arg Gln Arg Pro Thr Leu Pro Pro Pro Gln 
                725                 730                 735     


Pro Pro Thr Val Asn Leu Ser Ala Ser Ser Pro Gln Ser Thr Glu Ala 
            740                 745                 750         


Pro Met Leu Asp Gly Met Ser Pro Gly Glu Ser Met Ser Thr Asp Leu 
        755                 760                 765             


Val His Phe Asp Ile Pro Ser Ile His Ile Glu Leu Gly Ser Thr Leu 
    770                 775                 780                 


Arg Leu Ser Pro Leu Glu His Met Arg Arg His Ser Val Thr Asp Lys 
785                 790                 795                 800 


Arg Asp Ser Glu Glu Glu Ser Glu Ser Thr Ala Leu 
                805                 810         


<210> 5714
<211> 372
<212> PRT
<213> Homo sapiens

<400> 5714
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly 
                245                 250                 255     


Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp 
        275                 280                 285             


Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser 
    290                 295                 300                 


Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn 
305                 310                 315                 320 


Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg 
                325                 330                 335     


Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg 
            340                 345                 350         


Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Gly Arg Arg Phe 
    370         


<210> 5715
<211> 496
<212> PRT
<213> Homo sapiens

<400> 5715
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser Gly 
        115                 120                 125             


Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu Phe 
    130                 135                 140                 


Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn Ala 
145                 150                 155                 160 


Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro Ala 
                165                 170                 175     


Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile Val 
            180                 185                 190         


Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile Ser 
        195                 200                 205             


Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu Tyr 
    210                 215                 220                 


Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val Met 
225                 230                 235                 240 


Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn Lys 
                245                 250                 255     


Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu Gly 
            260                 265                 270         


Phe Lys Val Pro Gln Ala Gln Pro Thr Lys Pro Ala Leu Lys Ser Glu 
        275                 280                 285             


Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr Phe 
    290                 295                 300                 


Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu Asp 
305                 310                 315                 320 


Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly Ile 
                325                 330                 335     


Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln Gly 
            340                 345                 350         


His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys Ala 
        355                 360                 365             


Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr Ser 
    370                 375                 380                 


Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His Val 
385                 390                 395                 400 


Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu Ser 
                405                 410                 415     


Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn Asn 
            420                 425                 430         


Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro Leu 
        435                 440                 445             


Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met Ala 
    450                 455                 460                 


Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser Thr 
465                 470                 475                 480 


Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg Cys 
                485                 490                 495     


<210> 5716
<211> 1944
<212> PRT
<213> Homo sapiens

<400> 5716
Met Ser Asn Phe Tyr Glu Glu Arg Thr Thr Met Ile Ala Ala Arg Asp 
1               5                   10                  15      


Leu Gln Glu Phe Val Pro Phe Gly Arg Asp His Cys Lys His His Pro 
            20                  25                  30          


Asn Ala Leu Asn Leu Gln Leu Arg Gln Leu Gln Pro Ala Ser Glu Leu 
        35                  40                  45              


Trp Ser Ser Asp Gly Ala Ala Gly Leu Val Gly Ser Leu Gln Glu Val 
    50                  55                  60                  


Thr Ile His Glu Lys Gln Lys Glu Ser Trp Gln Leu Arg Lys Gly Val 
65                  70                  75                  80  


Ser Glu Ile Gly Glu Asp Val Asp Tyr Asp Glu Glu Leu Tyr Val Ala 
                85                  90                  95      


Gly Asn Met Val Ile Trp Ser Lys Gly Ser Lys Ser Gln Ala Leu Ala 
            100                 105                 110         


Val Tyr Lys Ala Phe Thr Val Asp Ser Pro Val Gln Gln Ala Leu Trp 
        115                 120                 125             


Cys Asp Phe Ile Ile Ser Gln Asp Lys Ser Glu Lys Ala Tyr Ser Ser 
    130                 135                 140                 


Asn Glu Val Glu Lys Cys Ile Cys Ile Leu Gln Ser Ser Cys Ile Asn 
145                 150                 155                 160 


Met His Ser Ile Glu Gly Lys Asp Tyr Ile Ala Ser Leu Pro Phe Gln 
                165                 170                 175     


Val Ala Asn Val Trp Pro Thr Lys Tyr Gly Leu Leu Phe Glu Arg Ser 
            180                 185                 190         


Ala Ser Ser His Glu Val Pro Pro Gly Ser Pro Arg Glu Pro Leu Pro 
        195                 200                 205             


Thr Met Phe Ser Met Leu His Pro Leu Asp Glu Ile Thr Pro Leu Val 
    210                 215                 220                 


Cys Lys Ser Gly Ser Leu Phe Gly Ser Ser Arg Val Gln Tyr Val Val 
225                 230                 235                 240 


Asp His Ala Met Lys Ile Val Phe Leu Asn Thr Asp Pro Ser Ile Val 
                245                 250                 255     


Met Thr Tyr Asp Ala Val Gln Asn Val His Ser Val Trp Thr Leu Arg 
            260                 265                 270         


Arg Val Lys Ser Glu Glu Glu Asn Val Val Leu Lys Phe Ser Glu Gln 
        275                 280                 285             


Gly Gly Thr Pro Gln Asn Val Ala Thr Ser Ser Ser Leu Thr Ala His 
    290                 295                 300                 


Leu Arg Ser Leu Ser Lys Gly Asp Ser Pro Val Thr Ser Pro Phe Gln 
305                 310                 315                 320 


Asn Tyr Ser Ser Ile His Ser Gln Ser Arg Ser Thr Ser Ser Pro Ser 
                325                 330                 335     


Leu His Ser Arg Ser Pro Ser Ile Ser Asn Met Ala Ala Leu Ser Arg 
            340                 345                 350         


Ala His Ser Pro Ala Leu Gly Val His Ser Phe Ser Gly Val Gln Arg 
        355                 360                 365             


Phe Asn Ile Ser Ser His Asn Gln Ser Pro Lys Arg His Ser Ile Ser 
    370                 375                 380                 


His Ser Pro Asn Ser Asn Ser Asn Gly Ser Phe Leu Ala Pro Glu Thr 
385                 390                 395                 400 


Glu Pro Ile Val Pro Glu Leu Cys Ile Asp His Leu Trp Thr Glu Thr 
                405                 410                 415     


Ile Thr Asn Ile Arg Glu Lys Asn Ser Gln Ala Ser Lys Val Phe Ile 
            420                 425                 430         


Thr Ser Asp Leu Cys Gly Gln Lys Phe Leu Cys Phe Leu Val Glu Ser 
        435                 440                 445             


Gln Leu Gln Leu Arg Cys Val Lys Phe Gln Glu Ser Asn Asp Lys Thr 
    450                 455                 460                 


Gln Leu Ile Phe Gly Ser Val Thr Asn Ile Pro Ala Lys Asp Ala Ala 
465                 470                 475                 480 


Pro Val Glu Lys Ile Asp Thr Met Leu Val Leu Glu Gly Ser Gly Asn 
                485                 490                 495     


Leu Val Leu Tyr Thr Gly Val Val Arg Val Gly Lys Val Phe Ile Pro 
            500                 505                 510         


Gly Leu Pro Ala Pro Ser Leu Thr Met Ser Asn Thr Met Pro Arg Pro 
        515                 520                 525             


Ser Thr Pro Leu Asp Gly Val Ser Thr Pro Lys Pro Leu Ser Lys Leu 
    530                 535                 540                 


Leu Gly Ser Leu Asp Glu Val Val Leu Leu Ser Pro Val Pro Glu Leu 
545                 550                 555                 560 


Arg Asp Ser Ser Lys Leu His Asp Ser Leu Tyr Asn Glu Asp Cys Thr 
                565                 570                 575     


Phe Gln Gln Leu Gly Thr Tyr Ile His Ser Ile Arg Asp Pro Val His 
            580                 585                 590         


Asn Arg Val Thr Leu Glu Leu Ser Asn Gly Ser Met Val Arg Ile Thr 
        595                 600                 605             


Ile Pro Glu Ile Ala Thr Ser Glu Leu Val Gln Thr Cys Leu Gln Ala 
    610                 615                 620                 


Ile Lys Phe Ile Leu Pro Lys Glu Ile Ala Val Gln Met Leu Val Lys 
625                 630                 635                 640 


Trp Tyr Asn Val His Ser Ala Pro Gly Gly Pro Ser Tyr His Ser Glu 
                645                 650                 655     


Trp Asn Leu Phe Val Thr Cys Leu Met Asn Met Met Gly Tyr Asn Thr 
            660                 665                 670         


Asp Arg Leu Ala Trp Thr Arg Asn Phe Asp Phe Glu Gly Ser Leu Ser 
        675                 680                 685             


Pro Val Ile Ala Pro Lys Lys Ala Arg Pro Ser Glu Thr Gly Ser Asp 
    690                 695                 700                 


Asp Asp Trp Glu Tyr Leu Leu Asn Ser Asp Tyr His Gln Asn Val Glu 
705                 710                 715                 720 


Ser His Leu Leu Asn Arg Ser Leu Cys Leu Ser Pro Ser Glu Ala Ser 
                725                 730                 735     


Gln Met Lys Asp Glu Asp Phe Ser Gln Asn Leu Ser Leu Asp Ser Ser 
            740                 745                 750         


Thr Leu Leu Phe Thr His Ile Pro Ala Ile Phe Phe Val Leu His Leu 
        755                 760                 765             


Val Tyr Glu Glu Leu Lys Leu Asn Thr Leu Met Gly Glu Gly Ile Cys 
    770                 775                 780                 


Ser Leu Val Glu Leu Leu Val Gln Leu Ala Arg Asp Leu Lys Leu Gly 
785                 790                 795                 800 


Pro Tyr Val Asp His Tyr Tyr Arg Asp Tyr Pro Thr Leu Val Arg Thr 
                805                 810                 815     


Thr Gly Gln Val Cys Thr Ile Asp Pro Gly Gln Thr Gly Phe Met His 
            820                 825                 830         


His Pro Ser Phe Phe Thr Ser Glu Pro Pro Ser Ile Tyr Gln Trp Val 
        835                 840                 845             


Ser Ser Cys Leu Lys Gly Glu Gly Met Pro Pro Tyr Pro Tyr Leu Pro 
    850                 855                 860                 


Gly Ile Cys Glu Arg Ser Arg Leu Val Val Leu Ser Ile Ala Leu Tyr 
865                 870                 875                 880 


Ile Leu Gly Asp Glu Ser Leu Val Ser Asp Glu Ser Ser Gln Tyr Leu 
                885                 890                 895     


Thr Arg Ile Thr Ile Ala Pro Gln Lys Leu Gln Val Glu Gln Glu Glu 
            900                 905                 910         


Asn Arg Phe Ser Phe Arg His Ser Thr Ser Val Ser Ser Leu Ala Glu 
        915                 920                 925             


Arg Leu Val Val Trp Met Thr Asn Val Gly Phe Thr Leu Arg Asp Leu 
    930                 935                 940                 


Glu Thr Leu Pro Phe Gly Ile Ala Leu Pro Ile Arg Asp Ala Ile Tyr 
945                 950                 955                 960 


His Cys Arg Glu Gln Pro Ala Ser Asp Trp Pro Glu Ala Val Cys Leu 
                965                 970                 975     


Leu Ile Gly Arg Gln Asp Leu Ser Lys Gln Ala Cys Glu Gly Asn Leu 
            980                 985                 990         


Pro Lys Gly Lys Ser Val Leu Ser  Ser Asp Val Pro Ser  Gly Thr Glu 
        995                 1000                 1005             


Thr Glu  Glu Glu Asp Asp Gly  Met Asn Asp Met Asn  His Glu Val 
    1010                 1015                 1020             


Met Ser  Leu Ile Trp Ser Glu  Asp Leu Arg Val Gln  Asp Val Arg 
    1025                 1030                 1035             


Arg Leu  Leu Gln Ser Ala His  Pro Val Arg Val Asn  Val Val Gln 
    1040                 1045                 1050             


Tyr Pro  Glu Leu Ser Asp His  Glu Phe Ile Glu Glu  Lys Glu Asn 
    1055                 1060                 1065             


Arg Leu  Leu Gln Leu Cys Gln  Arg Thr Met Ala Leu  Pro Val Gly 
    1070                 1075                 1080             


Arg Gly  Met Phe Thr Leu Phe  Ser Tyr His Pro Val  Pro Thr Glu 
    1085                 1090                 1095             


Pro Leu  Pro Ile Pro Lys Leu  Asn Leu Thr Gly Arg  Ala Pro Pro 
    1100                 1105                 1110             


Arg Asn  Thr Thr Val Asp Leu  Asn Ser Gly Asn Ile  Asp Val Pro 
    1115                 1120                 1125             


Pro Asn  Met Thr Ser Trp Ala  Ser Phe His Asn Gly  Val Ala Ala 
    1130                 1135                 1140             


Gly Leu  Lys Ile Ala Pro Ala  Ser Gln Ile Asp Ser  Ala Trp Ile 
    1145                 1150                 1155             


Val Tyr  Asn Lys Pro Lys His  Ala Glu Leu Ala Asn  Glu Tyr Ala 
    1160                 1165                 1170             


Gly Phe  Leu Met Ala Leu Gly  Leu Asn Gly His Leu  Thr Lys Leu 
    1175                 1180                 1185             


Ala Thr  Leu Asn Ile His Asp  Tyr Leu Thr Lys Gly  His Glu Met 
    1190                 1195                 1200             


Thr Ser  Ile Gly Leu Leu Leu  Gly Val Ser Ala Ala  Lys Leu Gly 
    1205                 1210                 1215             


Thr Met  Asp Met Ser Ile Thr  Arg Leu Leu Ser Ile  His Ile Pro 
    1220                 1225                 1230             


Ala Leu  Leu Pro Pro Thr Ser  Thr Glu Leu Asp Val  Pro His Asn 
    1235                 1240                 1245             


Val Gln  Val Ala Ala Val Val  Gly Ile Gly Leu Val  Tyr Gln Gly 
    1250                 1255                 1260             


Thr Ala  His Arg His Thr Ala  Glu Val Leu Leu Ala  Glu Ile Gly 
    1265                 1270                 1275             


Arg Pro  Pro Gly Pro Glu Met  Glu Tyr Cys Thr Asp  Arg Glu Ser 
    1280                 1285                 1290             


Tyr Ser  Leu Ala Ala Gly Leu  Ala Leu Gly Met Val  Cys Leu Gly 
    1295                 1300                 1305             


His Gly  Ser Asn Leu Ile Gly  Met Ser Asp Leu Asn  Val Pro Glu 
    1310                 1315                 1320             


Gln Leu  Tyr Gln Tyr Met Val  Gly Gly His Arg Arg  Phe Gln Thr 
    1325                 1330                 1335             


Gly Met  His Arg Glu Lys His  Lys Ser Pro Ser Tyr  Gln Ile Lys 
    1340                 1345                 1350             


Glu Gly  Asp Thr Ile Asn Val  Asp Val Thr Cys Pro  Gly Ala Thr 
    1355                 1360                 1365             


Leu Ala  Leu Ala Met Ile Tyr  Leu Lys Thr Asn Asn  Arg Ser Ile 
    1370                 1375                 1380             


Ala Asp  Trp Leu Arg Ala Pro  Asp Thr Met Tyr Leu  Leu Asp Phe 
    1385                 1390                 1395             


Val Lys  Pro Glu Phe Leu Leu  Leu Arg Thr Leu Ala  Arg Cys Leu 
    1400                 1405                 1410             


Ile Leu  Trp Asp Asp Ile Leu  Pro Asn Ser Lys Trp  Val Asp Ser 
    1415                 1420                 1425             


Asn Val  Pro Gln Ile Ile Arg  Glu Asn Ser Ile Ser  Leu Ser Glu 
    1430                 1435                 1440             


Ile Glu  Leu Pro Cys Ser Glu  Asp Leu Asn Leu Glu  Thr Leu Ser 
    1445                 1450                 1455             


Gln Ala  His Val Tyr Ile Ile  Ala Gly Ala Cys Leu  Ser Leu Gly 
    1460                 1465                 1470             


Phe Arg  Phe Ala Gly Ser Glu  Asn Leu Ser Ala Phe  Asn Cys Leu 
    1475                 1480                 1485             


His Lys  Phe Ala Lys Asp Phe  Met Thr Tyr Leu Ser  Ala Pro Asn 
    1490                 1495                 1500             


Ala Ser  Val Thr Gly Pro His  Asn Leu Glu Thr Cys  Leu Ser Val 
    1505                 1510                 1515             


Val Leu  Leu Ser Leu Ala Met  Val Met Ala Gly Ser  Gly Asn Leu 
    1520                 1525                 1530             


Lys Val  Leu Gln Leu Cys Arg  Phe Leu His Met Lys  Thr Gly Gly 
    1535                 1540                 1545             


Glu Met  Asn Tyr Gly Phe His  Leu Ala His His Met  Ala Leu Gly 
    1550                 1555                 1560             


Leu Leu  Phe Leu Gly Gly Gly  Arg Tyr Ser Leu Ser  Thr Ser Asn 
    1565                 1570                 1575             


Ser Ser  Ile Ala Ala Leu Leu  Cys Ala Leu Tyr Pro  His Phe Pro 
    1580                 1585                 1590             


Ala His  Ser Thr Asp Asn Arg  Tyr His Leu Gln Ala  Leu Arg His 
    1595                 1600                 1605             


Leu Tyr  Val Leu Ala Ala Glu  Pro Arg Leu Leu Val  Pro Val Asp 
    1610                 1615                 1620             


Val Asp  Thr Asn Thr Pro Cys  Tyr Ala Leu Leu Glu  Val Thr Tyr 
    1625                 1630                 1635             


Lys Gly  Thr Gln Trp Tyr Glu  Gln Thr Lys Glu Glu  Leu Met Ala 
    1640                 1645                 1650             


Pro Thr  Leu Leu Pro Glu Leu  His Leu Leu Lys Gln  Ile Lys Val 
    1655                 1660                 1665             


Lys Gly  Pro Arg Tyr Trp Glu  Leu Leu Ile Asp Leu  Ser Lys Gly 
    1670                 1675                 1680             


Thr Gln  His Leu Lys Ser Ile  Leu Ser Lys Asp Gly  Val Leu Tyr 
    1685                 1690                 1695             


Val Lys  Leu Arg Ala Gly Gln  Leu Ser Tyr Lys Glu  Asp Pro Met 
    1700                 1705                 1710             


Gly Trp  Gln Ser Leu Leu Ala  Gln Thr Val Ala Asn  Arg Asn Ser 
    1715                 1720                 1725             


Glu Ala  Arg Ala Phe Lys Pro  Glu Thr Ile Ser Ala  Phe Thr Ser 
    1730                 1735                 1740             


Asp Pro  Ala Leu Leu Ser Phe  Ala Glu Tyr Phe Cys  Lys Pro Thr 
    1745                 1750                 1755             


Val Asn  Met Gly Gln Lys Gln  Glu Ile Leu Asp Leu  Phe Ser Ser 
    1760                 1765                 1770             


Val Leu  Tyr Glu Cys Val Thr  Gln Glu Thr Pro Glu  Met Leu Pro 
    1775                 1780                 1785             


Ala Tyr  Ile Ala Met Asp Gln  Ala Ile Arg Arg Leu  Gly Arg Arg 
    1790                 1795                 1800             


Glu Met  Ser Glu Thr Ser Glu  Leu Trp Gln Ile Lys  Leu Val Leu 
    1805                 1810                 1815             


Glu Phe  Phe Ser Ser Arg Ser  His Gln Glu Arg Leu  Gln Asn His 
    1820                 1825                 1830             


Pro Lys  Arg Gly Leu Phe Met  Asn Ser Glu Phe Leu  Pro Val Val 
    1835                 1840                 1845             


Lys Cys  Thr Ile Asp Asn Thr  Leu Asp Gln Trp Leu  Gln Val Gly 
    1850                 1855                 1860             


Gly Asp  Met Cys Val His Ala  Tyr Leu Ser Gly Gln  Pro Leu Glu 
    1865                 1870                 1875             


Glu Ser  Gln Leu Ser Met Leu  Ala Cys Phe Leu Val  Tyr His Ser 
    1880                 1885                 1890             


Val Pro  Ala Pro Gln His Leu  Pro Pro Ile Gly Leu  Glu Gly Ser 
    1895                 1900                 1905             


Thr Ser  Phe Ala Glu Leu Leu  Phe Lys Phe Lys Gln  Leu Lys Met 
    1910                 1915                 1920             


Pro Val  Arg Ala Leu Leu Arg  Leu Ala Pro Leu Leu  Leu Gly Asn 
    1925                 1930                 1935             


Pro Gln  Pro Met Val Met 
    1940                 


<210> 5717
<211> 420
<212> PRT
<213> Homo sapiens

<400> 5717
Met Leu Lys Ala Val Ile Leu Ile Gly Gly Pro Gln Lys Gly Thr Arg 
1               5                   10                  15      


Phe Arg Pro Leu Ser Phe Glu Val Pro Lys Pro Leu Phe Pro Val Ala 
            20                  25                  30          


Gly Val Pro Met Ile Gln His His Ile Glu Ala Cys Ala Gln Val Pro 
        35                  40                  45              


Gly Met Gln Glu Ile Leu Leu Ile Gly Phe Tyr Gln Pro Asp Glu Pro 
    50                  55                  60                  


Leu Thr Gln Phe Leu Glu Ala Ala Gln Gln Glu Phe Asn Leu Pro Val 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Phe Ala Pro Leu Gly Thr Gly Gly Gly Leu Tyr 
                85                  90                  95      


His Phe Arg Asp Gln Ile Leu Ala Gly Ser Pro Glu Ala Phe Phe Val 
            100                 105                 110         


Leu Asn Ala Asp Val Cys Ser Asp Phe Pro Leu Ser Ala Met Leu Glu 
        115                 120                 125             


Ala His Arg Arg Gln Arg His Pro Phe Leu Leu Leu Gly Thr Thr Ala 
    130                 135                 140                 


Asn Arg Thr Gln Ser Leu Asn Tyr Gly Cys Ile Val Glu Asn Pro Gln 
145                 150                 155                 160 


Thr His Glu Val Leu His Tyr Val Glu Lys Pro Ser Thr Phe Ile Ser 
                165                 170                 175     


Asp Ile Ile Asn Cys Gly Ile Tyr Leu Phe Ser Pro Glu Ala Leu Lys 
            180                 185                 190         


Pro Leu Arg Asp Val Phe Gln Arg Asn Gln Gln Asp Gly Gln Leu Glu 
        195                 200                 205             


Asp Ser Pro Gly Leu Trp Pro Gly Ala Gly Thr Ile Arg Leu Glu Gln 
    210                 215                 220                 


Asp Val Phe Ser Ala Leu Ala Gly Gln Gly Gln Ile Tyr Val His Leu 
225                 230                 235                 240 


Thr Asp Gly Ile Trp Ser Gln Ile Lys Ser Ala Gly Ser Ala Leu Tyr 
                245                 250                 255     


Ala Ser Arg Leu Tyr Leu Ser Arg Tyr Gln Asp Thr His Pro Glu Arg 
            260                 265                 270         


Leu Ala Lys His Thr Pro Gly Gly Pro Trp Ile Arg Gly Asn Val Tyr 
        275                 280                 285             


Ile His Pro Thr Ala Lys Val Ala Pro Ser Ala Val Leu Gly Pro Asn 
    290                 295                 300                 


Val Ser Ile Gly Lys Gly Val Thr Val Gly Glu Gly Val Arg Leu Arg 
305                 310                 315                 320 


Glu Ser Ile Val Leu His Gly Ala Thr Leu Gln Glu His Thr Cys Val 
                325                 330                 335     


Leu His Ser Ile Val Gly Trp Gly Ser Thr Val Gly Arg Trp Ala Arg 
            340                 345                 350         


Val Glu Gly Thr Pro Ser Asp Pro Asn Pro Asn Asp Pro Arg Ala Arg 
        355                 360                 365             


Met Asp Ser Glu Ser Leu Phe Lys Asp Gly Lys Leu Leu Pro Ala Ile 
    370                 375                 380                 


Thr Ile Leu Gly Cys Arg Val Arg Ile Pro Ala Glu Val Leu Ile Leu 
385                 390                 395                 400 


Asn Ser Ile Val Leu Pro His Lys Glu Leu Ser Arg Ser Phe Thr Asn 
                405                 410                 415     


Gln Ile Ile Leu 
            420 


<210> 5718
<211> 418
<212> PRT
<213> Homo sapiens

<400> 5718
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Val Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Leu 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Ala Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ala Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Met Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp Leu Ala Ala Leu Glu Lys Asp Tyr 
385                 390                 395                 400 


Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu Gly Glu 
                405                 410                 415     


Glu Tyr 
        


<210> 5719
<211> 138
<212> PRT
<213> Homo sapiens

<400> 5719
Met Gln Leu Pro Pro Phe Asp Met Trp Lys Asp Tyr Phe Asn Leu Ser 
1               5                   10                  15      


Gln Val Val Trp Ala Leu Ile Ala Ser Arg Gly Gln Arg Leu Glu Thr 
            20                  25                  30          


Gln Glu Ile Glu Glu Pro Ser Pro Gly Pro Pro Leu Gly Gln Asp Gln 
        35                  40                  45              


Gly Leu Gly Ala Pro Gly Ala Asn Gly Gly Leu Gly Thr Leu Cys Asn 
    50                  55                  60                  


Phe Cys Lys His Asn Gly Glu Ser Arg His Val Tyr Ser Ser His Gln 
65                  70                  75                  80  


Leu Lys Thr Pro Asp Gly Val Val Val Cys Pro Ile Leu Arg His Tyr 
                85                  90                  95      


Val Cys Pro Val Cys Gly Ala Thr Gly Asp Gln Ala His Thr Leu Lys 
            100                 105                 110         


Tyr Cys Pro Leu Asn Gly Gly Gln Gln Ser Leu Tyr Arg Arg Ser Gly 
        115                 120                 125             


Arg Asn Ser Ala Gly Arg Arg Val Lys Arg 
    130                 135             


<210> 5720
<211> 124
<212> PRT
<213> Homo sapiens

<400> 5720
Met Arg Ala Ser Pro Cys Ile Ser Gln Pro Ala Ala Ser Trp His Pro 
1               5                   10                  15      


Arg Pro Ser Ala Leu Arg Pro Thr Ala Gly Ser Gly Pro Asp Thr Arg 
            20                  25                  30          


Thr Pro Gly Thr Val Glu Asp Gly Ser Ala Pro Cys Pro Ala Phe Arg 
        35                  40                  45              


Ser Pro Ala Val Ser Pro Cys Gly Glu Glu Pro Cys Cys Phe Gln Ile 
    50                  55                  60                  


Ser Pro Ala Glu Glu Thr Leu Glu Leu Gly Arg Leu Val Ser Pro Gly 
65                  70                  75                  80  


Asn Cys Asp Thr Leu Ser Pro Arg Ala Ala Gly Phe Tyr Ala Cys His 
                85                  90                  95      


Val Arg Ser Leu Ile Pro Cys Arg Ser Thr Lys Gly Arg Trp Pro Leu 
            100                 105                 110         


Thr Ala Ser Ala Ala Gly Leu Ser Ser Phe Ser Gly 
        115                 120                 


<210> 5721
<211> 120
<212> PRT
<213> Homo sapiens

<400> 5721
Met Ala Glu Pro Ser Ser Ala Arg Arg Pro Val Pro Leu Ile Glu Ser 
1               5                   10                  15      


Glu Leu Tyr Phe Leu Ile Ala Arg Tyr Leu Ser Ala Gly Pro Cys Arg 
            20                  25                  30          


Arg Ala Ala Gln Val Leu Val Gln Glu Leu Glu Gln Tyr Gln Leu Leu 
        35                  40                  45              


Pro Lys Arg Leu Asp Trp Glu Gly Asn Glu His Asn Arg Ser Tyr Glu 
    50                  55                  60                  


Glu Leu Val Leu Ser Asn Lys His Val Ala Pro Asp His Leu Leu Gln 
65                  70                  75                  80  


Ile Cys Gln Arg Ile Gly Pro Met Leu Asp Lys Glu Ile Pro Pro Ser 
                85                  90                  95      


Ile Ser Arg Val Thr Ser Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu 
            100                 105                 110         


Arg Thr Ala Lys Gly Thr Leu Ile 
        115                 120 


<210> 5722
<211> 868
<212> PRT
<213> Homo sapiens

<400> 5722
Met Ile Pro Lys Ser Leu Val Gln Ala Ala Glu Thr Gln Arg Gly Leu 
1               5                   10                  15      


Cys Glu Pro Gly Gly Lys Gly Arg Glu Gly Arg Ser Gly Gly Lys Gly 
            20                  25                  30          


Glu Thr Arg Pro Arg Gly Val Gly Thr Gln Glu Gly Lys Gly Thr Ile 
        35                  40                  45              


Pro Gly Ser Pro Arg Glu Lys Arg Gly Glu Arg Gly Glu Gly Asp Pro 
    50                  55                  60                  


Ala Leu Leu Pro Ala Glu Asp Leu Trp Arg Leu Pro Gly Ser Lys Asp 
65                  70                  75                  80  


Arg Leu Arg Ser Ser Leu Leu Pro Pro Pro Gly Pro Pro Ser Ser Asp 
                85                  90                  95      


Ser Gly Pro Gly Pro Pro Ser Ser His Ser Gly Lys Thr Ala Gln Gly 
            100                 105                 110         


Pro Arg Thr Leu Asn Trp Ala Arg Lys Gln Ser Ala Arg Thr Ser Ser 
        115                 120                 125             


Asn Leu Cys Ala Trp Ser Leu Ala Met Ala Thr Lys Met Ala Glu Ile 
    130                 135                 140                 


Pro Ser Ser Pro Tyr Glu Pro Gly Gln Arg Gly Met Lys Asp Thr Gln 
145                 150                 155                 160 


Arg Gly Asp Ala Pro Gln Arg Gly Ser Pro Glu Pro Arg Ile Leu Gln 
                165                 170                 175     


Leu Ala Arg Val Gly Asn Val Tyr Leu Lys Glu Glu Ser Ser Arg Ser 
            180                 185                 190         


Gly Arg Leu Glu Ala Lys Lys Trp Ile Pro Thr Lys Phe Leu Glu Asn 
        195                 200                 205             


Leu Ser Val Pro His Val Asp Leu Gly Gly Asn Gln Leu Trp Ser Gly 
    210                 215                 220                 


Gly Met Glu Ala Leu Thr Thr Gln Leu Gly Pro Gly Arg Glu Gly Ser 
225                 230                 235                 240 


Ser Ser Pro Asn Ser Lys Gln Glu Leu Gln Pro Tyr Ser Gly Ser Ser 
                245                 250                 255     


Ala Leu Lys Pro Asn Gln Val Gly Glu Thr Ser Leu Tyr Gly Val Pro 
            260                 265                 270         


Ile Val Ser Leu Val Ile Asp Gly Gln Glu Arg Leu Cys Leu Ala Gln 
        275                 280                 285             


Ile Ser Asn Thr Leu Leu Lys Asn Tyr Ser Tyr Asn Glu Ile His Asn 
    290                 295                 300                 


Arg Arg Val Ala Leu Gly Ile Thr Cys Val Gln Cys Thr Pro Val Gln 
305                 310                 315                 320 


Leu Glu Ile Leu Arg Arg Ala Gly Ala Met Pro Ile Ser Ser Arg Arg 
                325                 330                 335     


Cys Gly Met Ile Thr Lys Arg Glu Ala Glu Arg Leu Cys Lys Ser Phe 
            340                 345                 350         


Leu Gly Glu His Lys Pro Pro Lys Leu Pro Glu Asn Phe Ala Phe Asp 
        355                 360                 365             


Val Val His Glu Cys Ala Trp Gly Ser Arg Gly Ser Phe Ile Pro Ala 
    370                 375                 380                 


Arg Tyr Asn Ser Ser Arg Ala Lys Cys Ile Lys Cys Gly Tyr Cys Ser 
385                 390                 395                 400 


Met Tyr Phe Ser Pro Asn Lys Phe Ile Phe His Ser His Arg Thr Pro 
                405                 410                 415     


Asp Ala Lys Tyr Thr Gln Pro Asp Ala Ala Asn Phe Asn Ser Trp Arg 
            420                 425                 430         


Arg His Leu Lys Leu Ser Asp Lys Ser Ala Thr Asp Glu Leu Ser His 
        435                 440                 445             


Ala Trp Glu Asp Arg Gly Leu Gly Leu Ala Thr Gly Ala Ser Gly Pro 
    450                 455                 460                 


Ala Gly Pro Gly Gly Pro Gly Gly Gly Ala Gly Val Arg Ser Tyr Pro 
465                 470                 475                 480 


Val Ile Pro Val Pro Ser Lys Gly Phe Gly Leu Leu Gln Lys Leu Pro 
                485                 490                 495     


Pro Pro Leu Phe Pro His Pro Tyr Gly Phe Pro Thr Ala Phe Gly Leu 
            500                 505                 510         


Cys Pro Lys Lys Asp Asp Pro Val Leu Gly Ala Gly Glu Pro Lys Gly 
        515                 520                 525             


Gly Ser Tyr Val Ser Ala Phe Arg Pro Val Val Lys Asp Thr Glu Ser 
    530                 535                 540                 


Ile Ala Lys Leu Tyr Gly Ser Ala Arg Glu Ala Tyr Gly Ala Gly Pro 
545                 550                 555                 560 


Ala Arg Gly Pro Gly Pro Gly Ala Gly Ser Gly Gly Tyr Val Ser Pro 
                565                 570                 575     


Asp Phe Leu Ser Glu Gly Ser Ser Ser Tyr Asn Ser Ala Ser Pro Asp 
            580                 585                 590         


Val Asp Thr Ala Asp Glu Pro Glu Val Asp Val Glu Ser Asn Arg Phe 
        595                 600                 605             


Pro Asp Asp Glu Asp Ala Gln Glu Glu Thr Glu Pro Ser Ala Pro Ser 
    610                 615                 620                 


Ala Gly Gly Gly Pro Asp Ala Gly Arg Pro Ala Phe Gly Asp Leu Ala 
625                 630                 635                 640 


Ala Glu Asp Leu Val Arg Arg Pro Glu Arg Ser Pro Pro Ser Gly Gly 
                645                 650                 655     


Gly Gly Tyr Glu Leu Arg Glu Pro Cys Gly Pro Leu Gly Gly Pro Ala 
            660                 665                 670         


Pro Ala Lys Val Phe Ala Pro Glu Arg Asp Glu His Val Lys Ser Ala 
        675                 680                 685             


Ala Val Ala Leu Gly Pro Ala Ala Ser Tyr Val Cys Thr Pro Glu Ala 
    690                 695                 700                 


His Glu Pro Asp Lys Glu Asp Asn His Ser Pro Ala Asp Asp Leu Glu 
705                 710                 715                 720 


Thr Arg Lys Ser Tyr Pro Asp Gln Arg Ser Ile Ser Gln Pro Ser Pro 
                725                 730                 735     


Ala Asn Thr Asp Arg Gly Glu Asp Gly Leu Thr Leu Asp Val Thr Gly 
            740                 745                 750         


Thr His Leu Val Glu Lys Asp Ile Glu Asn Leu Ala Arg Glu Glu Leu 
        755                 760                 765             


Gln Lys Leu Leu Leu Glu Gln Met Glu Leu Arg Lys Lys Leu Glu Arg 
    770                 775                 780                 


Glu Phe Gln Ser Leu Lys Asp Asn Phe Gln Asp Gln Met Lys Arg Glu 
785                 790                 795                 800 


Leu Ala Tyr Arg Glu Glu Met Val Gln Gln Leu Gln Ile Val Arg Asp 
                805                 810                 815     


Thr Leu Cys Asn Glu Leu Asp Gln Glu Arg Lys Ala Arg Tyr Ala Ile 
            820                 825                 830         


Gln Gln Lys Leu Lys Glu Ala His Asp Ala Leu His His Phe Ser Cys 
        835                 840                 845             


Lys Met Leu Thr Pro Arg His Cys Thr Gly Asn Cys Ser Phe Lys Pro 
    850                 855                 860                 


Pro Leu Leu Pro 
865             


<210> 5723
<211> 1194
<212> PRT
<213> Homo sapiens

<400> 5723
Met His Asp Leu Pro Pro Asp Ser Gly Ala Arg Arg Gly Gly Arg Gly 
1               5                   10                  15      


Leu Ala Asp His Ser Phe Pro Ala Gly Ala Arg Ala Pro Gly Gln Pro 
            20                  25                  30          


Pro Ser Arg Gly Ala Ala Tyr Arg Arg Ala Cys Pro Arg Asp Gly Glu 
        35                  40                  45              


Arg Gly Gly Gly Gly Arg Pro Arg Gln Gln Val Ser Pro Pro Arg Ser 
    50                  55                  60                  


Pro Gln Arg Glu Pro Arg Gly Gly Gln Leu Arg Thr Pro Arg Met Arg 
65                  70                  75                  80  


Pro Ser Cys Ser Arg Ser Leu Glu Ser Leu Arg Val Gly Ala Lys Pro 
                85                  90                  95      


Pro Pro Phe Gln Arg Trp Pro Ser Asp Ser Trp Ile Arg Cys Gly Ala 
            100                 105                 110         


His Arg Asp Trp Asp Glu Pro Pro Pro Arg Gly Gly Arg Met Asp Gly 
        115                 120                 125             


Trp Ser Gly Asp Arg Ala Arg Ala Ala Ala Pro Thr Gly Leu Gln Pro 
    130                 135                 140                 


Pro Gly Cys Lys Asp His Gly Cys Ser Ser Gly Ser Pro Phe Arg Asp 
145                 150                 155                 160 


Pro Ala Gly Ser Ser Val Ile Arg Ser Gly Lys Gly Asp Arg Gln Glu 
                165                 170                 175     


Gly Pro Ser Phe Leu Arg Pro Pro Ala Val Thr Val Lys Lys Leu Gln 
            180                 185                 190         


Lys Trp Met Tyr Lys Gly Arg Leu Leu Ser Leu Gly Met Lys Gly Arg 
        195                 200                 205             


Ala Arg Gly Thr Ala Pro Lys Val Thr Gly Thr Gln Ala Ala Ser Pro 
    210                 215                 220                 


Asn Val Gly Ala Leu Lys Val Arg Glu Asn Arg Val Leu Ser Val Pro 
225                 230                 235                 240 


Pro Asp Gln Arg Ile Thr Leu Thr Asp Leu Phe Glu Asn Ala Tyr Gly 
                245                 250                 255     


Ser Ser Met Lys Gly Arg Glu Leu Glu Glu Leu Lys Asp Asn Ile Glu 
            260                 265                 270         


Phe Arg Gly His Lys Pro Leu Asn Ser Ile Thr Val Ser Lys Lys Arg 
        275                 280                 285             


Asn Trp Leu Tyr Gln Ser Thr Leu Arg Pro Leu Asn Leu Glu Glu Glu 
    290                 295                 300                 


Asn Lys Lys Cys Gln Asp Arg Ser His Leu Ser Ile Ser Pro Val Ser 
305                 310                 315                 320 


Leu Pro Lys His Gln Leu Ser Gln Ser Phe Leu Lys Ser Ser Lys Glu 
                325                 330                 335     


Tyr Cys Thr Tyr Val Val Cys Asn Ala Thr Asn Ser Ser Leu Ser Lys 
            340                 345                 350         


Asn Cys Ala Leu Asp Phe Asn Glu Glu Asn Asp Ala Asp Asp Glu Gly 
        355                 360                 365             


Glu Ile Trp Tyr Asn Pro Ile Pro Glu Asp Asp Asp Leu Gly Ile Ser 
    370                 375                 380                 


Ser Ala Leu Ser Phe Gly Glu Ala Asp Ser Ala Val Leu Lys Leu Pro 
385                 390                 395                 400 


Ala Val Asn Leu Ser Met Leu Ser Gly Ser Asp Leu Met Lys Ala Glu 
                405                 410                 415     


Arg His Thr Glu Asp Ser Leu Cys Ser Ser Glu His Ala Gly Asp Ile 
            420                 425                 430         


Gln Thr Thr Arg Ser Asn Gly Met Asn Pro Ile His Pro Ala His Ser 
        435                 440                 445             


Thr Glu Phe Val Gln Gln Tyr Lys Gln Lys Leu Gly His Lys Thr Gln 
    450                 455                 460                 


Glu Gly Ile Met Val Glu Asp Ser Pro Met Leu Lys Ser Pro Phe Ala 
465                 470                 475                 480 


Gly Ser Gly Ile Leu Ala Ala Thr Asn Ser Thr Glu Leu Gly Ile Met 
                485                 490                 495     


Glu Pro Ser Ser Pro Asn Pro Ser Pro Val Lys Lys Gly Ser Ser Ile 
            500                 505                 510         


Asn Trp Ser Leu Pro Asp Lys Ile Lys Ser Pro Arg Thr Val Arg Lys 
        515                 520                 525             


Leu Ser Met Lys Met Lys Lys Leu Pro Glu Phe Ser Arg Lys Leu Ser 
    530                 535                 540                 


Val Lys Gly Thr Leu Asn Tyr Ile Asn Ser Pro Asp Asn Thr Pro Ser 
545                 550                 555                 560 


Leu Ser Lys Tyr Asn Cys Arg Glu Val His His Thr Asp Ile Leu Pro 
                565                 570                 575     


Ser Gly Asn Thr Thr Thr Ala Ala Lys Arg Asn Val Ile Ser Arg Tyr 
            580                 585                 590         


His Leu Asp Thr Ser Val Ser Ser Gln Gln Ser Tyr Gln Lys Lys Asn 
        595                 600                 605             


Ser Met Ser Ser Lys Tyr Ser Cys Lys Gly Gly Tyr Leu Ser Asp Gly 
    610                 615                 620                 


Asp Ser Pro Glu Leu Thr Thr Lys Ala Ser Lys His Gly Ser Glu Asn 
625                 630                 635                 640 


Lys Phe Gly Lys Gly Lys Glu Ile Ile Ser Asn Ser Cys Ser Lys Asn 
                645                 650                 655     


Glu Ile Asp Ile Asp Ala Phe Arg His Tyr Ser Phe Ser Asp Gln Pro 
            660                 665                 670         


Lys Cys Ser Gln Tyr Ile Ser Gly Leu Met Ser Val His Phe Tyr Gly 
        675                 680                 685             


Ala Glu Asp Leu Lys Pro Pro Arg Ile Asp Ser Lys Asp Val Phe Cys 
    690                 695                 700                 


Ala Ile Gln Val Asp Ser Val Asn Lys Ala Arg Thr Ala Leu Leu Thr 
705                 710                 715                 720 


Cys Arg Thr Thr Phe Leu Asp Met Asp His Thr Phe Asn Ile Glu Ile 
                725                 730                 735     


Glu Asn Ala Gln His Leu Lys Leu Val Val Phe Ser Trp Glu Pro Thr 
            740                 745                 750         


Pro Arg Lys Asn Arg Val Cys Cys His Gly Thr Val Val Leu Pro Thr 
        755                 760                 765             


Leu Phe Arg Val Thr Lys Thr His Gln Leu Ala Val Lys Leu Glu Pro 
    770                 775                 780                 


Arg Gly Leu Ile Tyr Val Lys Val Thr Leu Met Glu Gln Trp Glu Asn 
785                 790                 795                 800 


Ser Leu His Gly Leu Asp Ile Asn Gln Glu Pro Ile Ile Phe Gly Val 
                805                 810                 815     


Asp Ile Gln Lys Val Val Glu Lys Glu Asn Ile Gly Leu Met Val Pro 
            820                 825                 830         


Leu Leu Ile Gln Lys Cys Ile Met Glu Ile Glu Lys Arg Gly Cys Gln 
        835                 840                 845             


Val Val Gly Leu Tyr Arg Leu Cys Gly Ser Ala Ala Val Lys Lys Glu 
    850                 855                 860                 


Leu Arg Glu Ala Phe Glu Arg Asp Ser Lys Ala Val Gly Leu Cys Glu 
865                 870                 875                 880 


Asn Gln Tyr Pro Asp Ile Asn Val Ile Thr Gly Val Leu Lys Asp Tyr 
                885                 890                 895     


Leu Arg Glu Leu Pro Ser Pro Leu Ile Thr Lys Gln Leu Tyr Glu Ala 
            900                 905                 910         


Val Leu Asp Ala Met Ala Lys Ser Pro Leu Lys Met Ser Ser Asn Gly 
        915                 920                 925             


Cys Glu Asn Asp Pro Gly Asp Ser Lys Tyr Thr Val Asp Leu Leu Asp 
    930                 935                 940                 


Cys Leu Pro Glu Ile Glu Lys Ala Thr Leu Lys Met Leu Leu Asp His 
945                 950                 955                 960 


Leu Lys Leu Val Ala Ser Tyr His Glu Val Asn Lys Met Thr Cys Gln 
                965                 970                 975     


Asn Leu Ala Val Cys Phe Gly Pro Val Leu Leu Ser Gln Arg Gln Glu 
            980                 985                 990         


Pro Ser Thr His Asn Asn Arg Val  Phe Thr Asp Ser Glu  Glu Leu Ala 
        995                 1000                 1005             


Ser Ala  Leu Asp Phe Lys Lys  His Ile Glu Val Leu  His Tyr Leu 
    1010                 1015                 1020             


Leu Gln  Leu Trp Pro Val Gln  Arg Leu Thr Val Lys  Lys Ser Thr 
    1025                 1030                 1035             


Asp Asn  Leu Phe Pro Glu Gln  Lys Ser Ser Leu Asn  Tyr Leu Arg 
    1040                 1045                 1050             


Gln Lys  Lys Glu Arg Pro His  Met Leu Asn Leu Ser  Gly Thr Asp 
    1055                 1060                 1065             


Ser Ser  Gly Val Leu Arg Pro  Arg Gln Asn Arg Leu  Asp Ser Pro 
    1070                 1075                 1080             


Leu Ser  Asn Arg Tyr Ala Gly  Asp Trp Ser Ser Cys  Gly Glu Asn 
    1085                 1090                 1095             


Tyr Phe  Leu Asn Thr Lys Glu  Asn Leu Asn Asp Val  Asp Tyr Asp 
    1100                 1105                 1110             


Asp Val  Pro Ser Glu Asp Arg  Lys Ile Gly Glu Asn  Tyr Ser Lys 
    1115                 1120                 1125             


Met Asp  Gly Pro Glu Val Met  Ile Glu Gln Pro Ile  Pro Met Ser 
    1130                 1135                 1140             


Lys Glu  Cys Thr Phe Gln Thr  Tyr Leu Thr Met Gln  Thr Val Glu 
    1145                 1150                 1155             


Ser Thr  Val Asp Arg Lys Asn  Asn Leu Lys Asp Leu  Gln Glu Ser 
    1160                 1165                 1170             


Ile Asp  Thr Leu Ile Gly Asn  Leu Glu Arg Glu Leu  Asn Lys Asn 
    1175                 1180                 1185             


Lys Leu  Asn Met Ser Phe 
    1190                 


<210> 5724
<211> 450
<212> PRT
<213> Homo sapiens

<400> 5724
Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile 
1               5                   10                  15      


Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro 
        35                  40                  45              


Glu Val Glu Pro Asp Leu Gly Glu Lys Ala Ile Glu Ser Ala Pro Glu 
    50                  55                  60                  


Lys Arg Leu Thr Leu Ala Gln Ile Tyr Glu Trp Met Val Arg Thr Val 
65                  70                  75                  80  


Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys 
                85                  90                  95      


Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile Lys Val 
            100                 105                 110         


His Asn Glu Ala Thr Gly Lys Ser Ser Trp Trp Met Leu Asn Pro Glu 
        115                 120                 125             


Gly Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Ala Ser Met Asp 
    130                 135                 140                 


Ser Ser Ser Lys Leu Leu Arg Gly Arg Ser Lys Ala Pro Lys Lys Lys 
145                 150                 155                 160 


Pro Ser Val Leu Pro Ala Pro Pro Glu Gly Ala Thr Pro Thr Ser Pro 
                165                 170                 175     


Val Gly His Phe Ala Lys Trp Ser Gly Ser Pro Cys Ser Arg Asn Arg 
            180                 185                 190         


Glu Glu Ala Asp Met Trp Thr Thr Phe Arg Pro Arg Ser Ser Ser Asn 
        195                 200                 205             


Ala Ser Ser Val Ser Thr Arg Leu Ser Pro Leu Arg Pro Glu Ser Glu 
    210                 215                 220                 


Val Leu Ala Glu Glu Ile Pro Ala Ser Val Ser Ser Tyr Ala Gly Gly 
225                 230                 235                 240 


Val Pro Pro Thr Leu Asn Glu Gly Leu Glu Leu Leu Asp Gly Leu Asn 
                245                 250                 255     


Leu Thr Ser Ser His Ser Leu Leu Ser Arg Ser Gly Leu Ser Gly Phe 
            260                 265                 270         


Ser Leu Gln His Pro Gly Val Thr Gly Pro Leu His Thr Tyr Ser Ser 
        275                 280                 285             


Ser Leu Phe Ser Pro Ala Glu Gly Pro Leu Ser Ala Gly Glu Gly Cys 
    290                 295                 300                 


Phe Ser Ser Ser Gln Ala Leu Glu Ala Leu Leu Thr Ser Asp Thr Pro 
305                 310                 315                 320 


Pro Pro Pro Ala Asp Val Leu Met Thr Gln Val Asp Pro Ile Leu Ser 
                325                 330                 335     


Gln Ala Pro Thr Leu Leu Leu Leu Gly Gly Leu Pro Ser Ser Ser Lys 
            340                 345                 350         


Leu Ala Thr Gly Val Gly Leu Cys Pro Lys Pro Leu Glu Ala Pro Gly 
        355                 360                 365             


Pro Ser Ser Leu Val Pro Thr Leu Ser Met Ile Ala Pro Pro Pro Val 
    370                 375                 380                 


Met Ala Ser Ala Pro Ile Pro Lys Ala Leu Gly Thr Pro Val Leu Thr 
385                 390                 395                 400 


Pro Pro Thr Glu Ala Ala Ser Gln Asp Arg Met Pro Gln Asp Leu Asp 
                405                 410                 415     


Leu Asp Met Tyr Met Glu Asn Leu Glu Cys Asp Met Asp Asn Ile Ile 
            420                 425                 430         


Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp Phe Asn Phe Glu Pro 
        435                 440                 445             


Asp Pro 
    450 


<210> 5725
<211> 374
<212> PRT
<213> Homo sapiens

<400> 5725
Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ala Glu Met 
                85                  90                  95      


Glu Leu Val Gln His Ile Gly Ile Pro Ala Ser Lys Ile Ile Cys Ala 
            100                 105                 110         


Asn Pro Cys Lys Gln Ile Ala Gln Ile Lys Tyr Ala Ala Lys His Gly 
        115                 120                 125             


Ile Gln Leu Leu Ser Phe Asp Asn Glu Met Glu Leu Ala Lys Val Val 
    130                 135                 140                 


Lys Ser His Pro Ser Ala Lys Phe Val Gln Gln Arg Gly Thr Ala Cys 
145                 150                 155                 160 


Leu Ile Arg Met Val Leu Cys Ile Ala Thr Asp Asp Ser His Ser Leu 
                165                 170                 175     


Ser Cys Leu Ser Leu Lys Phe Gly Val Ser Leu Lys Ser Cys Arg His 
            180                 185                 190         


Leu Leu Glu Asn Ala Lys Lys His His Val Glu Val Val Gly Val Ser 
        195                 200                 205             


Phe His Ile Gly Ser Gly Cys Pro Asp Pro Gln Ala Tyr Ala Gln Ser 
    210                 215                 220                 


Ile Ala Asp Ala Arg Leu Val Phe Glu Met Gly Thr Glu Leu Gly His 
225                 230                 235                 240 


Lys Met His Val Leu Asp Leu Gly Gly Gly Phe Pro Gly Thr Glu Gly 
                245                 250                 255     


Ala Lys Val Arg Phe Glu Glu Ile Ala Ser Val Ile Asn Ser Ala Leu 
            260                 265                 270         


Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val Asp Ile Phe Ala Glu Leu 
        275                 280                 285             


Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr Val Ala Val Ser Ile Ile 
    290                 295                 300                 


Ala Lys Lys Glu Val Leu Leu Asp Gln Pro Gly Arg Glu Glu Glu Asn 
305                 310                 315                 320 


Gly Ser Thr Ser Lys Thr Ile Val Tyr His Leu Asp Glu Gly Val Tyr 
                325                 330                 335     


Gly Ile Phe Asn Ser Val Leu Phe Asp Asn Ile Cys Pro Thr Pro Ile 
            340                 345                 350         


Leu Gln Lys Ser Lys Asn His Ser Pro Cys Tyr Met Ser Leu Glu Ser 
        355                 360                 365             


Ile His Phe Ile Ala Val 
    370                 


<210> 5726
<211> 542
<212> PRT
<213> Homo sapiens

<400> 5726
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val 
1               5                   10                  15      


Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val 
            20                  25                  30          


Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser 
        35                  40                  45              


Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile 
    50                  55                  60                  


Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser 
65                  70                  75                  80  


Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala 
                85                  90                  95      


Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn 
            100                 105                 110         


Ile Leu Arg Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala 
        115                 120                 125             


Leu Thr Glu Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser 
    130                 135                 140                 


Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile 
145                 150                 155                 160 


Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp 
                165                 170                 175     


Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser 
            180                 185                 190         


Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser 
        195                 200                 205             


Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala 
    210                 215                 220                 


Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe 
225                 230                 235                 240 


Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp 
                245                 250                 255     


Pro Asp Tyr Leu Pro Arg Thr Glu Met Asp Pro Lys Leu Arg Pro Ser 
            260                 265                 270         


Phe Val Glu Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln 
        275                 280                 285             


Glu Glu Glu Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly 
    290                 295                 300                 


Leu Leu Glu Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp 
305                 310                 315                 320 


Lys Ile Pro His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser 
                325                 330                 335     


Arg Ser Gln Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser 
            340                 345                 350         


Val Leu Asp Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro 
        355                 360                 365             


Lys Val Asn Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile 
    370                 375                 380                 


Lys Phe Phe Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp 
385                 390                 395                 400 


Leu Asp Ala Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu 
                405                 410                 415     


Pro Leu Ala Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro 
            420                 425                 430         


Glu Phe Leu His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser 
        435                 440                 445             


Leu Ser Asp Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val 
    450                 455                 460                 


Lys Glu Ile Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala 
465                 470                 475                 480 


His Glu Ala Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly 
                485                 490                 495     


Ser Arg Pro Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu 
            500                 505                 510         


Met Glu Val Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser 
        515                 520                 525             


Thr Ser Gly Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly 
    530                 535                 540         


<210> 5727
<211> 261
<212> PRT
<213> Homo sapiens

<400> 5727
Met Gly Ser Arg Lys Lys Glu Ile Ala Leu Gln Val Asn Ile Ser Thr 
1               5                   10                  15      


Gln Glu Leu Trp Glu Glu Met Leu Ser Ser Lys Gly Leu Thr Val Val 
            20                  25                  30          


Asp Val Tyr Gln Gly Trp Cys Gly Pro Cys Lys Pro Val Val Ser Leu 
        35                  40                  45              


Phe Gln Lys Met Arg Ile Glu Val Gly Leu Asp Leu Leu His Phe Ala 
    50                  55                  60                  


Leu Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val Ser His 
65                  70                  75                  80  


Gly Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu Arg Thr 
                85                  90                  95      


Cys Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly Lys Thr 
            100                 105                 110         


Asp Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile Leu Thr 
        115                 120                 125             


Asn Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe Tyr Gln 
    130                 135                 140                 


His Lys Ala Gly Glu Glu Ala Phe Glu Lys Leu Val His His Met Cys 
145                 150                 155                 160 


Ser Gly Pro Ser His Leu Leu Ile Leu Thr Arg Thr Glu Gly Phe Glu 
                165                 170                 175     


Asp Val Val Thr Thr Trp Arg Thr Val Met Gly Pro Arg Asp Pro Asn 
            180                 185                 190         


Val Ala Arg Arg Glu Gln Pro Glu Ser Leu Arg Ala Gln Tyr Gly Thr 
        195                 200                 205             


Glu Met Pro Phe Asn Ala Val His Gly Ser Arg Asp Arg Glu Asp Ala 
    210                 215                 220                 


Asp Arg Glu Leu Ala Leu Leu Phe Pro Ser Leu Lys Phe Ser Asp Lys 
225                 230                 235                 240 


Asp Thr Glu Ala Pro Gln Gly Glu Ser Ser Thr Gln Pro Arg Leu Lys 
                245                 250                 255     


Ile Thr Asp Leu Asp 
            260     


<210> 5728
<211> 588
<212> PRT
<213> Homo sapiens

<400> 5728
Met Glu Ala Ala Asp Ala Ser Arg Ser Asn Gly Ser Ser Pro Glu Ala 
1               5                   10                  15      


Arg Asp Ala Arg Ser Pro Ser Gly Pro Ser Gly Ser Leu Glu Asn Gly 
            20                  25                  30          


Thr Lys Ala Asp Gly Lys Asp Ala Lys Thr Thr Asn Gly His Gly Gly 
        35                  40                  45              


Glu Ala Ala Glu Gly Lys Ser Leu Gly Ser Ala Leu Lys Pro Gly Glu 
    50                  55                  60                  


Gly Arg Ser Ala Leu Phe Ala Gly Asn Glu Trp Arg Arg Pro Ile Ile 
65                  70                  75                  80  


Gln Phe Val Glu Ser Gly Asp Asp Lys Asn Ser Asn Tyr Phe Ser Met 
                85                  90                  95      


Asp Ser Met Glu Gly Lys Arg Ser Pro Tyr Ala Gly Leu Gln Leu Gly 
            100                 105                 110         


Ala Ala Lys Lys Pro Pro Val Thr Phe Ala Glu Lys Gly Glu Leu Arg 
        115                 120                 125             


Lys Ser Ile Phe Ser Glu Ser Arg Lys Pro Thr Val Ser Ile Met Glu 
    130                 135                 140                 


Pro Gly Glu Thr Arg Arg Asn Ser Tyr Pro Arg Ala Asp Thr Gly Leu 
145                 150                 155                 160 


Phe Ser Arg Ser Lys Ser Gly Ser Glu Glu Val Leu Cys Asp Ser Cys 
                165                 170                 175     


Ile Gly Asn Lys Gln Lys Ala Val Lys Ser Cys Leu Val Cys Gln Ala 
            180                 185                 190         


Ser Phe Cys Glu Leu His Leu Lys Pro His Leu Glu Gly Ala Ala Phe 
        195                 200                 205             


Arg Asp His Gln Leu Leu Glu Pro Ile Arg Asp Phe Glu Ala Arg Lys 
    210                 215                 220                 


Cys Pro Val His Gly Lys Thr Met Glu Leu Phe Cys Gln Thr Asp Gln 
225                 230                 235                 240 


Thr Cys Ile Cys Tyr Leu Cys Met Phe Gln Glu His Lys Asn His Ser 
                245                 250                 255     


Thr Val Thr Val Glu Glu Ala Lys Ala Glu Lys Glu Thr Glu Leu Ser 
            260                 265                 270         


Leu Gln Lys Glu Gln Leu Gln Leu Lys Ile Ile Glu Ile Glu Asp Glu 
        275                 280                 285             


Ala Glu Lys Trp Gln Lys Glu Lys Asp Arg Ile Lys Ser Phe Thr Thr 
    290                 295                 300                 


Asn Glu Lys Ala Ile Leu Glu Gln Asn Phe Arg Asp Leu Val Arg Asp 
305                 310                 315                 320 


Leu Glu Lys Gln Lys Glu Glu Val Arg Ala Ala Leu Glu Gln Arg Glu 
                325                 330                 335     


Gln Asp Ala Val Asp Gln Val Lys Val Ile Met Asp Ala Leu Asp Glu 
            340                 345                 350         


Arg Ala Lys Val Leu His Glu Asp Lys Gln Thr Arg Glu Gln Leu His 
        355                 360                 365             


Ser Ile Ser Asp Ser Val Leu Phe Leu Gln Glu Phe Gly Ala Leu Met 
    370                 375                 380                 


Ser Asn Tyr Ser Leu Pro Pro Pro Leu Pro Thr Tyr His Val Leu Leu 
385                 390                 395                 400 


Glu Gly Glu Gly Leu Gly Gln Ser Leu Gly Asn Phe Lys Asp Asp Leu 
                405                 410                 415     


Leu Asn Val Cys Met Arg His Val Glu Lys Met Cys Lys Ala Asp Leu 
            420                 425                 430         


Ser Arg Asn Phe Ile Glu Arg Asn His Met Glu Asn Gly Gly Asp His 
        435                 440                 445             


Arg Tyr Val Asn Asn Tyr Thr Asn Ser Phe Gly Gly Glu Trp Ser Ala 
    450                 455                 460                 


Pro Asp Thr Met Lys Arg Tyr Ser Met Tyr Leu Thr Pro Lys Gly Gly 
465                 470                 475                 480 


Val Arg Thr Ser Tyr Gln Pro Ser Ser Pro Gly Arg Phe Thr Lys Glu 
                485                 490                 495     


Thr Thr Gln Lys Asn Phe Asn Asn Leu Tyr Gly Thr Lys Gly Asn Tyr 
            500                 505                 510         


Thr Ser Arg Val Trp Glu Tyr Ser Ser Ser Ile Gln Asn Ser Asp Asn 
        515                 520                 525             


Asp Leu Pro Val Val Gln Gly Ser Ser Ser Phe Ser Leu Lys Gly Tyr 
    530                 535                 540                 


Pro Ser Leu Met Arg Ser Gln Ser Pro Lys Ala Gln Pro Gln Thr Trp 
545                 550                 555                 560 


Lys Ser Gly Lys Gln Thr Met Leu Ser His Tyr Arg Pro Phe Tyr Val 
                565                 570                 575     


Asn Lys Gly Asn Gly Ile Gly Ser Asn Glu Ala Pro 
            580                 585             


<210> 5729
<211> 1188
<212> PRT
<213> Homo sapiens

<400> 5729
Met Lys Lys Lys Gln Thr Val Gln Gly Thr Phe Ser Lys Leu Phe Gly 
1               5                   10                  15      


Lys Lys His Thr Thr Thr Pro Ser Thr Ser Leu Tyr Ala Thr Asn Pro 
            20                  25                  30          


Pro Trp Ile Phe Thr Gln Glu Ala Pro Glu Glu Gly Thr Gly Gly Phe 
        35                  40                  45              


Asp Gly Ile Tyr Tyr Gly Asp Asn Arg Phe Asn Thr Val Ser Glu Ser 
    50                  55                  60                  


Gly Thr Ala Thr Leu Lys Ala Arg Pro Arg Val Arg Pro Leu Leu Thr 
65                  70                  75                  80  


Phe Leu Pro Leu Asn Ala Gln Glu Asn His Gly Leu Ala Val Pro Thr 
                85                  90                  95      


Pro Ser Val Pro Asp Asp Phe Ala Asp Lys Glu Val Thr Gly Thr Ser 
            100                 105                 110         


Ser Leu Val Asn Gly Asn Leu Arg Leu Tyr Ser Ser Val Gly Asp Leu 
        115                 120                 125             


Arg Pro Gly Gln Tyr Gly Gln Asp Leu Leu Ile Pro Pro Pro Pro Pro 
    130                 135                 140                 


Gly Pro Ala Pro Gly Pro Pro Gln Asp Ile Ser Glu Pro Pro Gly Gly 
145                 150                 155                 160 


Ser Pro Leu Pro Ser Pro Pro Ser Thr Ala Pro Pro Pro Pro Pro Leu 
                165                 170                 175     


Leu Leu Glu Pro Pro Pro Pro Pro Ser Met Ala Pro Pro Pro Pro Pro 
            180                 185                 190         


Val Leu Glu Ala Leu Ser Pro Pro His Thr Leu Ser Ser Pro Ser Ile 
        195                 200                 205             


Pro Thr Pro Pro Asp Phe Ile Pro Pro Ala Pro Pro Leu Ala Phe Leu 
    210                 215                 220                 


Ala Pro Pro Pro Pro Pro Val Pro Ala Pro Ala Pro Pro Ala Pro Ala 
225                 230                 235                 240 


Ser Pro His Thr Val Gly Thr Arg Leu Phe Pro Pro Gly Gly Val Thr 
                245                 250                 255     


Lys Trp Lys Ser Asp Val Ala Leu Asn Gly Arg Gln Ala Glu Ala Thr 
            260                 265                 270         


Arg Ala Ser Pro Pro Arg Ser Pro Ala Glu Pro Lys Gly Ser Ala Leu 
        275                 280                 285             


Gly Pro Asn Pro Glu Pro His Leu Thr Phe Pro Arg Ser Phe Lys Val 
    290                 295                 300                 


Pro Pro Pro Thr Pro Val Arg Thr Ser Ser Ile Pro Val Gln Glu Ala 
305                 310                 315                 320 


Gln Glu Ala Pro Arg Lys Glu Glu Gly Ala Thr Lys Lys Ala Pro Ser 
                325                 330                 335     


Arg Leu Pro Leu Pro Pro Ser Phe His Ile Arg Pro Ala Ser Gln Val 
            340                 345                 350         


Tyr Pro Asp Arg Ala Pro Glu Pro Asp Cys Pro Gly Glu Leu Lys Ala 
        355                 360                 365             


Thr Ala Pro Ala Ser Pro Arg Leu Gly Gln Ser Gln Ser Gln Ala Asp 
    370                 375                 380                 


Glu Arg Ala Gly Thr Pro Pro Pro Ala Pro Pro Leu Pro Pro Pro Ala 
385                 390                 395                 400 


Pro Pro Leu Pro Pro Pro Ala Pro Pro Leu Pro Pro Ala Ala Pro Pro 
                405                 410                 415     


Leu Pro Cys Ala Gln Lys Ala Ala His Pro Pro Ala Gly Phe Thr Lys 
            420                 425                 430         


Thr Pro Lys Ser Ser Ser Pro Ala Leu Lys Pro Lys Pro Asn Pro Pro 
        435                 440                 445             


Ser Pro Glu Asn Thr Ala Ser Ser Ala Pro Val Asp Trp Arg Asp Pro 
    450                 455                 460                 


Ser Gln Met Glu Lys Leu Arg Asn Glu Leu Ala Ala Tyr Leu Cys Gly 
465                 470                 475                 480 


Ser Arg Arg Glu Asp Arg Phe Leu Ser His Arg Pro Gly Pro Thr Val 
                485                 490                 495     


Ala Pro Gln Ser Lys Glu Gly Lys Lys Gly Pro Arg Leu Pro Glu Lys 
            500                 505                 510         


Glu Thr Leu Leu Ser Leu Pro Ala Lys Asp Thr Pro Pro Gly Val Pro 
        515                 520                 525             


Glu Lys Ser Leu Gly Gly Ser Ser Leu Thr Glu Thr Glu Ala Ala Pro 
    530                 535                 540                 


Ser Leu Thr Leu Pro Ser Val Asp Tyr Ile Pro Gln Asp Ser Pro Thr 
545                 550                 555                 560 


Pro Ser Val Arg Gln Ile Arg Asn Glu Leu Glu Ala Arg Leu Ser Ser 
                565                 570                 575     


Ala Ala Glu Lys Glu Ala Lys Pro Ser Ile Gly Ser Leu Pro Pro Lys 
            580                 585                 590         


Pro Arg Leu Glu Gly Gly Arg Ile Cys Glu Asn Gly Ala Asp Asp Asp 
        595                 600                 605             


Lys Leu Ser Lys Pro Val Ala Lys Asn Leu Pro Pro Gln Ser Thr Thr 
    610                 615                 620                 


Leu Leu Pro Thr Thr Ser Leu Gln Pro Lys Ala Met Leu Gly Pro Ala 
625                 630                 635                 640 


Ile Pro Pro Lys Ala Thr Pro Glu Pro Ala Ile Pro Pro Lys Ala Thr 
                645                 650                 655     


Leu Trp Pro Ala Thr Pro Pro Lys Ala Thr Leu Gly Pro Ala Thr Pro 
            660                 665                 670         


Leu Lys Ala Thr Ser Gly Pro Thr Thr Pro Leu Lys Ala Thr Ser Gly 
        675                 680                 685             


Pro Ala Ile Ala Ser Thr Ala Thr Thr Leu Pro Thr Thr Thr Ser Gln 
    690                 695                 700                 


Leu Met Ala Glu Lys Asp Ser Gly Pro Ala Gly Gln Pro Glu Lys Pro 
705                 710                 715                 720 


Ala Ser Gln Glu Val Ser Thr Pro Ser Gln Ala Arg Gly Glu Gly Ser 
                725                 730                 735     


Pro Ser Glu Ala Thr Arg Leu Pro Thr Gln Gly Ala Arg Ser Ser Ala 
            740                 745                 750         


Ala Phe Pro Pro Lys Thr Ser Pro Gly Gly Gly Glu Val Pro Cys Leu 
        755                 760                 765             


Tyr Lys Pro His Cys His Gln Ser Ser Leu Ser Arg Glu Val Ala Val 
    770                 775                 780                 


Val Met Pro Thr Leu Ala Arg Gly Gly Ala Ala Gly Pro Gly Glu Pro 
785                 790                 795                 800 


Val Glu Val Lys Glu Pro Pro Gly Leu Pro Ala Lys Pro Pro Ala Ser 
                805                 810                 815     


Ala Gln Pro Thr Asp Glu Leu Leu Arg His Pro Val Thr Gly Glu Val 
            820                 825                 830         


Val Glu Arg Gly Ser Pro Met Ala Leu Leu Leu Ala Ala Arg Gln Arg 
        835                 840                 845             


Ala Gln Lys Gly Arg Ser Val Gly Ala Ala Leu Gly Arg Ser Ser Leu 
    850                 855                 860                 


Pro Gly Ser Leu Arg Asp His Ser His Gln Ala Glu Ala Ser Ser Asp 
865                 870                 875                 880 


Ser Ile Phe His Ser Gln Gly Thr Pro Asn Ser Phe Thr Val Val Pro 
                885                 890                 895     


Lys Leu Pro Lys Glu Ala Glu Lys Asp Ser Pro Leu Thr Thr Glu Ile 
            900                 905                 910         


Pro Asn Lys Trp Gly Pro Arg Leu Gly Arg Asp Ala Glu Gly Thr Glu 
        915                 920                 925             


Leu Ser Arg Arg His Asn Trp Thr Lys Pro Glu Pro Gln Ala Pro Val 
    930                 935                 940                 


Ala Trp Glu Arg Val Ala Pro Ser Asn Leu Pro Gln Gly His Pro Leu 
945                 950                 955                 960 


Pro Lys Ser Phe Ser Ser Pro Pro Ser Pro Ser Asn Lys Arg Glu Glu 
                965                 970                 975     


Glu Glu Glu Glu Phe Asn Phe Glu Val Ile Pro Pro Pro Pro Glu Phe 
            980                 985                 990         


Ser Asn Asp Pro Glu Pro Pro Ala  Pro Ala Leu Gln Tyr  Leu Gly Arg 
        995                 1000                 1005             


Gln Ser  Ser Pro Pro Arg Asn  Asn Tyr Ser Asp Leu  Arg Gln Leu 
    1010                 1015                 1020             


Pro Asn  Ala Gly Pro Gly Ala  Pro Pro Ala Leu Gly  Phe Ser Arg 
    1025                 1030                 1035             


Phe Pro  Ala Gly Ala Arg Tyr  Ala Gly Ala Gly Gly  Leu Glu Arg 
    1040                 1045                 1050             


Phe Ser  Gly Gly Gly Arg Ser  Leu Ile Lys Lys Arg  Leu Tyr Val 
    1055                 1060                 1065             


Gly Glu  Pro His Arg Gly Pro  Gly Leu Pro His Gly  Gly Thr Gly 
    1070                 1075                 1080             


Arg Ser  Leu Ser Ser Pro Asn  Cys Phe Gly Pro Gln  Pro Gly Gly 
    1085                 1090                 1095             


Pro Glu  Met Arg Arg Val Asn  Ser Ala Gly Arg Ala  Pro Pro Gly 
    1100                 1105                 1110             


Gly Leu  His Ala Pro Arg Leu  Ser Leu Glu Gly Ala  Ala Arg Gly 
    1115                 1120                 1125             


Ala Ala  Glu Ala Lys His Lys  Ala Pro Gly Ser Ala  Asp Tyr Gly 
    1130                 1135                 1140             


Phe Ala  Pro Ala Ala Gly Arg  Ser Pro Tyr Thr Thr  Thr Arg Tyr 
    1145                 1150                 1155             


Gly Ser  Pro Ile Asn Thr Phe  Thr Val Arg Pro Gly  Thr Arg His 
    1160                 1165                 1170             


Pro Ile  Ser Tyr Val Cys Ser  Gly Ala His Arg Lys  Ala Thr Ser 
    1175                 1180                 1185             


<210> 5730
<211> 865
<212> PRT
<213> Homo sapiens

<400> 5730
Met Ala Val Ala Arg Val Asp Ala Ala Leu Pro Pro Gly Glu Gly Ser 
1               5                   10                  15      


Val Val Asn Trp Ser Gly Gln Gly Leu Gln Lys Leu Gly Pro Asn Leu 
            20                  25                  30          


Pro Cys Glu Ala Asp Ile His Thr Leu Ile Leu Asp Lys Asn Gln Ile 
        35                  40                  45              


Ile Lys Leu Glu Asn Leu Glu Lys Cys Lys Arg Leu Ile Gln Leu Ser 
    50                  55                  60                  


Val Ala Asn Asn Arg Leu Val Arg Met Met Gly Val Ala Lys Leu Thr 
65                  70                  75                  80  


Leu Leu Arg Val Leu Asn Leu Pro His Asn Ser Ile Gly Cys Val Glu 
                85                  90                  95      


Gly Leu Lys Glu Leu Val His Leu Glu Trp Leu Asn Leu Ala Gly Asn 
            100                 105                 110         


Asn Leu Lys Ala Met Glu Gln Ile Asn Ser Cys Thr Ala Leu Gln His 
        115                 120                 125             


Leu Asp Leu Ser Asp Asn Asn Ile Ser Gln Ile Gly Asp Leu Ser Lys 
    130                 135                 140                 


Leu Val Ser Leu Lys Thr Leu Leu Leu His Gly Asn Ile Ile Thr Ser 
145                 150                 155                 160 


Leu Arg Met Ala Pro Ala Tyr Leu Pro Arg Ser Leu Ala Ile Leu Ser 
                165                 170                 175     


Leu Ala Glu Asn Glu Ile Arg Asp Leu Asn Glu Ile Ser Phe Leu Ala 
            180                 185                 190         


Ser Leu Thr Glu Leu Glu Gln Leu Ser Ile Met Asn Asn Pro Cys Val 
        195                 200                 205             


Met Ala Thr Pro Ser Ile Pro Gly Phe Asp Tyr Arg Pro Tyr Ile Val 
    210                 215                 220                 


Ser Trp Cys Leu Asn Leu Arg Val Leu Asp Gly Tyr Val Ile Ser Gln 
225                 230                 235                 240 


Lys Glu Ser Leu Lys Ala Glu Trp Leu Tyr Ser Gln Gly Lys Gly Arg 
                245                 250                 255     


Ala Tyr Arg Pro Gly Gln His Ile Gln Leu Val Gln Tyr Leu Ala Thr 
            260                 265                 270         


Val Cys Pro Leu Thr Ser Thr Leu Gly Leu Gln Thr Ala Glu Asp Ala 
        275                 280                 285             


Lys Leu Glu Lys Ile Leu Ser Lys Gln Arg Phe His Gln Arg Gln Leu 
    290                 295                 300                 


Met Asn Gln Ser Gln Asn Glu Glu Leu Ser Pro Leu Val Pro Val Glu 
305                 310                 315                 320 


Thr Arg Ala Ser Leu Ile Pro Glu His Ser Ser Pro Val Gln Asp Cys 
                325                 330                 335     


Gln Ile Ser Gln Glu Ser Glu Pro Val Ile Gln Val Asn Ser Trp Val 
            340                 345                 350         


Gly Ile Asn Ser Asn Asp Asp Gln Leu Phe Ala Val Lys Asn Asn Phe 
        355                 360                 365             


Pro Ala Ser Val His Thr Thr Arg Tyr Ser Arg Asn Asp Leu His Leu 
    370                 375                 380                 


Glu Asp Ile Gln Thr Asp Glu Asp Lys Leu Asn Cys Ser Leu Leu Ser 
385                 390                 395                 400 


Ser Glu Ser Thr Phe Met Pro Val Ala Ser Gly Leu Ser Pro Leu Ser 
                405                 410                 415     


Pro Thr Val Glu Leu Arg Leu Gln Gly Ile Asn Leu Gly Leu Glu Asp 
            420                 425                 430         


Asp Gly Val Ala Asp Glu Ser Val Lys Gly Leu Glu Ser Gln Val Leu 
        435                 440                 445             


Asp Lys Glu Glu Glu Gln Pro Leu Trp Ala Ala Asn Glu Asn Ser Val 
    450                 455                 460                 


Gln Met Met Arg Ser Glu Ile Asn Thr Glu Val Asn Glu Lys Ala Gly 
465                 470                 475                 480 


Leu Leu Pro Cys Pro Glu Pro Thr Ile Ile Ser Ala Ile Leu Lys Asp 
                485                 490                 495     


Asp Asn His Ser Leu Thr Phe Phe Pro Glu Ser Thr Glu Gln Lys Gln 
            500                 505                 510         


Ser Asp Ile Lys Lys Pro Glu Asn Thr Gln Pro Glu Asn Lys Glu Thr 
        515                 520                 525             


Ile Ser Gln Ala Thr Ser Glu Lys Leu Pro Met Ile Leu Thr Gln Arg 
    530                 535                 540                 


Ser Val Ala Leu Gly Gln Asp Lys Val Ala Leu Gln Lys Leu Asn Asp 
545                 550                 555                 560 


Ala Ala Thr Lys Leu Gln Ala Cys Trp Arg Gly Phe Tyr Ala Arg Asn 
                565                 570                 575     


Tyr Asn Pro Gln Ala Lys Asp Val Arg Tyr Glu Ile Arg Leu Arg Arg 
            580                 585                 590         


Met Gln Glu His Ile Val Cys Leu Thr Asp Glu Ile Arg Arg Leu Arg 
        595                 600                 605             


Lys Glu Arg Asp Glu Glu Arg Ile Lys Lys Phe Val Gln Glu Glu Ala 
    610                 615                 620                 


Phe Arg Phe Leu Trp Asn Gln Val Arg Ser Leu Gln Val Trp Gln Gln 
625                 630                 635                 640 


Thr Val Asp Gln Arg Leu Ser Ser Trp His Thr Asp Val Pro Pro Ile 
                645                 650                 655     


Ser Ser Thr Leu Val Pro Ser Lys His Pro Leu Phe Thr Gln Ser Gln 
            660                 665                 670         


Glu Ser Ser Cys Asp Gln Asn Ala Asp Trp Phe Ile Ala Ser Asp Val 
        675                 680                 685             


Ala Pro Gln Glu Lys Ser Leu Pro Glu Phe Pro Asp Ser Gly Phe His 
    690                 695                 700                 


Ser Ser Leu Thr Glu Gln Val His Ser Leu Gln His Ser Leu Asp Phe 
705                 710                 715                 720 


Glu Lys Ser Ser Thr Glu Gly Ser Glu Ser Ser Ile Met Gly Asn Ser 
                725                 730                 735     


Ile Asp Thr Val Arg Tyr Gly Lys Glu Ser Asp Leu Gly Asp Val Ser 
            740                 745                 750         


Glu Glu His Gly Glu Trp Asn Lys Glu Ser Ser Asn Asn Glu Gln Asp 
        755                 760                 765             


Asn Ser Leu Leu Glu Gln Tyr Leu Thr Ser Val Gln Gln Leu Glu Asp 
    770                 775                 780                 


Ala Asp Glu Arg Thr Asn Phe Asp Thr Glu Thr Arg Asp Ser Lys Leu 
785                 790                 795                 800 


His Ile Ala Cys Phe Pro Val Gln Leu Asp Thr Leu Ser Asp Gly Ala 
                805                 810                 815     


Ser Val Asp Glu Ser His Gly Ile Ser Pro Pro Leu Gln Gly Glu Ile 
            820                 825                 830         


Ser Gln Thr Gln Glu Asn Ser Lys Leu Asn Ala Glu Val Gln Gly Gln 
        835                 840                 845             


Gln Pro Glu Cys Asp Ser Thr Phe Gln Leu Leu His Val Gly Val Thr 
    850                 855                 860                 


Val 
865 


<210> 5731
<211> 424
<212> PRT
<213> Homo sapiens

<400> 5731
Met Ser Val Gly Cys Pro Glu Pro Glu Pro Pro Arg Ser Leu Thr Cys 
1               5                   10                  15      


Cys Gly Pro Gly Thr Ala Pro Gly Pro Gly Ala Gly Val Pro Leu Leu 
            20                  25                  30          


Thr Glu Asp Met Gln Ala Leu Thr Leu Arg Thr Leu Ala Ala Ser Asp 
        35                  40                  45              


Val Thr Lys His Tyr Glu Leu Val Arg Glu Leu Gly Lys Gly Thr Tyr 
    50                  55                  60                  


Gly Lys Val Asp Leu Val Val Tyr Lys Gly Thr Gly Thr Lys Met Ala 
65                  70                  75                  80  


Leu Lys Phe Val Asn Lys Ser Lys Thr Lys Leu Lys Asn Phe Leu Arg 
                85                  90                  95      


Glu Val Ser Ile Thr Asn Ser Leu Ser Ser Ser Pro Phe Ile Ile Lys 
            100                 105                 110         


Val Phe Asp Val Val Phe Glu Thr Glu Asp Cys Tyr Val Phe Ala Gln 
        115                 120                 125             


Glu Tyr Ala Pro Ala Gly Asp Leu Phe Asp Ile Ile Pro Pro Gln Val 
    130                 135                 140                 


Gly Leu Pro Glu Asp Thr Val Lys Arg Cys Val Gln Gln Leu Gly Leu 
145                 150                 155                 160 


Ala Leu Asp Phe Met His Gly Arg Gln Leu Val His Arg Asp Ile Lys 
                165                 170                 175     


Pro Glu Asn Val Leu Leu Phe Asp Arg Glu Cys Arg Arg Val Lys Leu 
            180                 185                 190         


Ala Asp Phe Gly Met Thr Arg Arg Val Gly Cys Arg Val Lys Arg Val 
        195                 200                 205             


Ser Gly Thr Ile Pro Tyr Thr Ala Pro Glu Val Cys Gln Ala Gly Arg 
    210                 215                 220                 


Ala Asp Gly Leu Ala Val Asp Thr Gly Val Asp Val Trp Ala Phe Gly 
225                 230                 235                 240 


Val Leu Ile Phe Cys Val Leu Thr Gly Asn Phe Pro Trp Glu Ala Ala 
                245                 250                 255     


Ser Gly Ala Asp Ala Phe Phe Glu Glu Phe Val Arg Trp Gln Arg Gly 
            260                 265                 270         


Arg Leu Pro Gly Leu Pro Ser Gln Trp Arg Arg Phe Thr Glu Pro Ala 
        275                 280                 285             


Leu Arg Met Phe Gln Arg Leu Leu Ala Leu Glu Pro Glu Arg Arg Gly 
    290                 295                 300                 


Pro Ala Lys Glu Val Phe Arg Phe Leu Lys His Glu Leu Thr Ser Glu 
305                 310                 315                 320 


Leu Arg Arg Arg Pro Ser His Arg Ala Arg Lys Pro Pro Gly Asp Arg 
                325                 330                 335     


Pro Pro Ala Ala Gly Pro Leu Arg Leu Glu Ala Pro Gly Pro Leu Lys 
            340                 345                 350         


Arg Thr Val Leu Thr Glu Ser Gly Ser Gly Ser Arg Pro Ala Pro Pro 
        355                 360                 365             


Ala Val Gly Ser Val Pro Leu Pro Val Pro Val Pro Val Pro Val Pro 
    370                 375                 380                 


Val Pro Val Pro Val Pro Glu Pro Gly Leu Ala Pro Gln Gly Pro Pro 
385                 390                 395                 400 


Gly Arg Thr Asp Gly Arg Ala Asp Lys Ser Lys Gly Gln Val Val Leu 
                405                 410                 415     


Ala Thr Ala Ile Glu Ile Cys Val 
            420                 


<210> 5732
<211> 543
<212> PRT
<213> Homo sapiens

<400> 5732
Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu Gly Ala Leu Asn 
1               5                   10                  15      


Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys Glu Thr Arg Thr 
            20                  25                  30          


Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His Arg Ala Leu Gln 
        35                  40                  45              


Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu Leu His Ala Leu 
    50                  55                  60                  


Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu 
                85                  90                  95      


Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala 
            100                 105                 110         


Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser 
        115                 120                 125             


Pro Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val Leu Val Ala Asp 
    130                 135                 140                 


His Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys Val Arg Leu Val 
145                 150                 155                 160 


Pro Ala Val Arg Asp Pro His Met Leu Thr Phe Leu Gln Gln Leu Arg 
                165                 170                 175     


Val Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser His Thr Leu Arg 
            180                 185                 190         


Ser His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp Gly Arg Thr Leu 
        195                 200                 205             


Ser Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu Leu Val Glu Glu 
    210                 215                 220                 


Gln Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp Asn Cys Leu Val 
225                 230                 235                 240 


Thr Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln Glu Ala Leu Trp 
                245                 250                 255     


His Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly Ala Ser Asp Thr 
            260                 265                 270         


Gly Thr Gly Gly Cys Leu Val Val His Val Val Ser Cys Glu Glu Glu 
        275                 280                 285             


Phe Gln Gln Gln Lys Leu Asp Leu Leu Trp Gln Lys Leu Val Asp Lys 
    290                 295                 300                 


Ala Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro Val Lys Val Ala 
305                 310                 315                 320 


Gly Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr Tyr Glu Phe Arg 
                325                 330                 335     


His Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His Gly Gly Asp Leu 
            340                 345                 350         


Ala Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val Leu Ser Val Ala 
        355                 360                 365             


Thr Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln Ser Gln Leu Phe 
    370                 375                 380                 


Leu Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly Thr Lys Ser Gly 
385                 390                 395                 400 


Thr Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr Leu Phe Glu Ser 
                405                 410                 415     


Tyr Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr Phe Pro Pro Val 
            420                 425                 430         


Ser Ser Leu Asp Phe Ser Leu Leu His Asp Glu Gly Glu Trp Leu Leu 
        435                 440                 445             


Leu Phe Asn Ser Ile Leu Pro Phe Pro Asp Leu Leu Ser Arg Thr Ala 
    450                 455                 460                 


Val Leu Asp Cys Thr Ala Pro Gly Leu His Ile Ala Val Arg Thr Glu 
465                 470                 475                 480 


Met Ile Cys Lys Phe Leu Val Gln Leu Ser Met Asp Phe Ser Ser Tyr 
                485                 490                 495     


Tyr Asn Arg Val His Ile Leu Gly Glu Pro Arg Pro His Leu Phe Gly 
            500                 505                 510         


Gln Met Phe Val Arg Leu Gln Leu Leu Arg Ala Val Arg Glu Val Leu 
        515                 520                 525             


His Thr Gly Leu Ala Met Leu Gly Leu Pro Pro Leu Ser His Ile 
    530                 535                 540             


<210> 5733
<211> 450
<212> PRT
<213> Homo sapiens

<400> 5733
Met Gly Lys Ser Phe Ala Asn Phe Met Cys Lys Lys Asp Phe His Pro 
1               5                   10                  15      


Ala Ser Lys Ser Asn Ile Lys Lys Val Trp Met Ala Glu Gln Lys Ile 
            20                  25                  30          


Ser Tyr Asp Lys Lys Lys Gln Glu Glu Leu Met Gln Gln Tyr Leu Lys 
        35                  40                  45              


Glu Gln Glu Ser Tyr Asp Asn Arg Leu Leu Met Gly Asp Glu Arg Val 
    50                  55                  60                  


Lys Asn Gly Leu Asn Phe Met Tyr Glu Ala Pro Pro Gly Ala Lys Lys 
65                  70                  75                  80  


Glu Asn Lys Glu Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe 
                85                  90                  95      


Glu Trp Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met 
            100                 105                 110         


Asn Ile Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys 
        115                 120                 125             


Ile Lys Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro 
    130                 135                 140                 


Leu Phe Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly 
145                 150                 155                 160 


Ser Gly Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn 
                165                 170                 175     


Ser Gly Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala 
            180                 185                 190         


Asn Asp Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro 
        195                 200                 205             


Glu Val Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln Lys Leu 
    210                 215                 220                 


Leu Arg Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg 
225                 230                 235                 240 


Lys Lys Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Glu 
            260                 265                 270         


Thr Ser Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys 
        275                 280                 285             


Ile Gln Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn 
    290                 295                 300                 


Ser Asp Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu 
305                 310                 315                 320 


Glu Leu Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro 
                325                 330                 335     


Arg Phe Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His 
            340                 345                 350         


Ser Asp Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro Glu Lys 
        355                 360                 365             


Arg Gly Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu 
    370                 375                 380                 


Glu Arg Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln 
385                 390                 395                 400 


Arg Glu Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln Ser 
                405                 410                 415     


Arg Arg Asn Asp Ser Arg Ser His Gly Thr Asp Leu Tyr Arg Gly Glu 
            420                 425                 430         


Lys Met Tyr Arg Glu His Pro Gly Gly Thr His Thr Lys Val Thr Gln 
        435                 440                 445             


Arg Glu 
    450 


<210> 5734
<211> 383
<212> PRT
<213> Homo sapiens

<400> 5734
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 
            20                  25                  30          


Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Ala Tyr Phe Lys Thr 
        355                 360                 365             


Phe Val Pro Gln Phe Gln Glu Ala Ala Phe Ala Asn Gly Lys Leu 
    370                 375                 380             


<210> 5735
<211> 224
<212> PRT
<213> Homo sapiens

<400> 5735
Met Pro Asn Arg Cys Gly Ile Ile His Val Arg Gly Pro Met Pro Pro 
1               5                   10                  15      


Asn Arg Ile Ser His Gly Glu Val Leu Glu Trp Gln Lys Thr Phe Glu 
            20                  25                  30          


Glu Lys Leu Thr Pro Leu Leu Ser Val Arg Glu Ser Leu Ser Glu Glu 
        35                  40                  45              


Glu Ala Gln Lys Met Gly Arg Lys Asp Pro Glu Gln Glu Val Glu Lys 
    50                  55                  60                  


Phe Val Thr Ser Asn Thr Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys 
65                  70                  75                  80  


Pro Leu Ser Gly Lys Lys Phe Lys Gly Pro Glu Phe Val Arg Lys His 
                85                  90                  95      


Ile Phe Asn Lys His Ala Glu Lys Ile Glu Glu Val Lys Lys Glu Val 
            100                 105                 110         


Ala Phe Phe Asn Asn Phe Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro 
        115                 120                 125             


Glu Ile Lys Pro Ala Gln Pro Pro Gly Pro Ala Gln Ile Leu Pro Pro 
    130                 135                 140                 


Gly Leu Thr Pro Gly Leu Pro Tyr Pro His Gln Thr Pro Gln Gly Leu 
145                 150                 155                 160 


Met Pro Tyr Gly Gln Pro Arg Pro Pro Ile Gly Leu Trp Ser Trp Cys 
                165                 170                 175     


Cys Pro Pro Cys Ser Pro Gln Glu Ala Leu His Thr Pro Met Pro Arg 
            180                 185                 190         


Met Val Leu Val Glu Gly Thr Met Met Pro Ser Glu Ala Arg Glu Val 
        195                 200                 205             


Ile Leu Gly Asn Leu Ala Thr Gly Trp Phe Val Glu Thr Gln Gly Pro 
    210                 215                 220                 


<210> 5736
<211> 1601
<212> PRT
<213> Homo sapiens

<400> 5736
Met Glu Ala Gly Ser Val Val Arg Ala Ile Phe Asp Phe Cys Pro Ser 
1               5                   10                  15      


Val Ser Glu Glu Leu Pro Leu Phe Val Gly Asp Ile Ile Glu Val Leu 
            20                  25                  30          


Ala Val Val Asp Glu Phe Trp Leu Leu Gly Lys Lys Glu Asp Val Thr 
        35                  40                  45              


Gly Gln Phe Pro Ser Ser Phe Val Glu Ile Val Thr Ile Pro Ser Leu 
    50                  55                  60                  


Lys Glu Gly Glu Arg Leu Phe Val Cys Ile Cys Glu Phe Thr Ser Gln 
65                  70                  75                  80  


Glu Leu Asp Asn Leu Pro Leu His Arg Gly Asp Leu Val Ile Leu Asp 
                85                  90                  95      


Gly Ile Pro Thr Ala Gly Trp Leu Gln Gly Arg Ser Cys Trp Gly Ala 
            100                 105                 110         


Arg Gly Phe Phe Pro Ser Ser Cys Val Arg Glu Leu Cys Leu Ser Ser 
        115                 120                 125             


Gln Ser Arg Gln Trp His Ser Gln Ser Ala Leu Phe Gln Ile Pro Glu 
    130                 135                 140                 


Tyr Ser Met Gly Gln Ala Arg Ala Leu Met Gly Leu Ser Ala Gln Leu 
145                 150                 155                 160 


Asp Glu Glu Leu Asp Phe Arg Glu Gly Asp Val Ile Thr Ile Ile Gly 
                165                 170                 175     


Val Pro Glu Pro Gly Trp Phe Glu Gly Glu Leu Glu Gly Arg Arg Gly 
            180                 185                 190         


Ile Phe Pro Glu Gly Phe Val Glu Leu Leu Gly Pro Leu Arg Thr Val 
        195                 200                 205             


Asp Glu Ser Val Ser Ser Gly Asn Gln Asp Asp Cys Ile Val Asn Gly 
    210                 215                 220                 


Glu Val Asp Thr Pro Val Gly Glu Glu Glu Ile Gly Pro Asp Glu Asp 
225                 230                 235                 240 


Glu Glu Glu Pro Gly Thr Tyr Gly Val Ala Leu Tyr Arg Phe Gln Ala 
                245                 250                 255     


Leu Glu Pro Asn Glu Leu Asp Phe Glu Val Gly Asp Lys Ile Arg Ile 
            260                 265                 270         


Leu Ala Thr Leu Glu Asp Gly Trp Leu Glu Gly Ser Leu Lys Gly Arg 
        275                 280                 285             


Thr Gly Ile Phe Pro Tyr Arg Phe Val Lys Leu Cys Pro Asp Thr Arg 
    290                 295                 300                 


Val Glu Glu Thr Met Ala Leu Pro Gln Glu Gly Ser Leu Ala Arg Ile 
305                 310                 315                 320 


Pro Glu Thr Ser Leu Asp Cys Leu Glu Asn Thr Leu Gly Val Glu Glu 
                325                 330                 335     


Gln Arg His Glu Thr Ser Asp His Glu Ala Glu Glu Pro Asp Cys Ile 
            340                 345                 350         


Ile Ser Glu Ala Pro Thr Ser Pro Leu Gly His Leu Thr Ser Glu Tyr 
        355                 360                 365             


Asp Thr Asp Arg Asn Ser Tyr Gln Asp Glu Asp Thr Ala Gly Gly Pro 
    370                 375                 380                 


Pro Arg Ser Pro Gly Val Glu Trp Glu Met Pro Leu Ala Thr Asp Ser 
385                 390                 395                 400 


Pro Thr Ser Asp Pro Thr Glu Val Val Asn Gly Ile Ser Ser Gln Pro 
                405                 410                 415     


Gln Val Pro Phe His Pro Asn Leu Gln Lys Ser Gln Tyr Tyr Ser Thr 
            420                 425                 430         


Val Gly Gly Ser His Pro His Ser Glu Gln Tyr Pro Asp Leu Leu Pro 
        435                 440                 445             


Leu Glu Ala Arg Thr Arg Asp Tyr Ala Ser Leu Pro Pro Lys Arg Met 
    450                 455                 460                 


Tyr Ser Gln Leu Lys Thr Leu Gln Lys Pro Val Leu Pro Leu Tyr Arg 
465                 470                 475                 480 


Gly Ser Ser Val Ser Ala Ser Arg Val Val Lys Pro Arg Gln Ser Ser 
                485                 490                 495     


Pro Gln Leu His Asn Leu Ala Ser Tyr Thr Lys Lys His His Thr Ser 
            500                 505                 510         


Ser Val Tyr Ser Ile Ser Glu Arg Leu Glu Met Lys Pro Gly Pro Gln 
        515                 520                 525             


Ala Gln Gly Leu Val Met Glu Ala Ala Thr His Ser Gln Gly Asp Gly 
    530                 535                 540                 


Ser Thr Asp Leu Asp Ser Lys Leu Thr Gln Gln Leu Ile Glu Phe Glu 
545                 550                 555                 560 


Lys Ser Leu Ala Gly Pro Gly Thr Glu Pro Asp Lys Ile Leu Arg His 
                565                 570                 575     


Phe Ser Ile Met Asp Phe Asn Ser Glu Lys Asp Ile Val Arg Gly Ser 
            580                 585                 590         


Ser Lys Leu Ile Thr Glu Gln Glu Leu Pro Glu Arg Arg Lys Ala Leu 
        595                 600                 605             


Arg Pro Pro Pro Pro Arg Pro Cys Thr Pro Val Ser Thr Ser Pro His 
    610                 615                 620                 


Leu Leu Val Asp Gln Asn Leu Lys Pro Ala Pro Pro Leu Val Val Arg 
625                 630                 635                 640 


Pro Ser Arg Pro Ala Pro Leu Pro Pro Ser Ala Gln Gln Arg Thr Asn 
                645                 650                 655     


Ala Val Ser Pro Lys Leu Leu Ser Arg His Arg Pro Thr Cys Glu Thr 
            660                 665                 670         


Leu Glu Lys Glu Gly Pro Gly His Met Gly Arg Ser Leu Asp Gln Thr 
        675                 680                 685             


Ser Pro Cys Pro Leu Val Leu Val Arg Ile Glu Glu Met Glu Arg Asp 
    690                 695                 700                 


Leu Asp Met Tyr Ser Arg Ala Gln Glu Glu Leu Asn Leu Met Leu Glu 
705                 710                 715                 720 


Glu Lys Gln Asp Glu Ser Ser Arg Ala Glu Thr Leu Glu Asp Leu Lys 
                725                 730                 735     


Phe Cys Glu Ser Asn Ile Glu Ser Leu Asn Met Glu Leu Gln Gln Leu 
            740                 745                 750         


Arg Glu Met Thr Leu Leu Ser Ser Gln Ser Ser Ser Leu Val Ala Pro 
        755                 760                 765             


Ser Gly Ser Val Ser Ala Glu Asn Pro Glu Gln Arg Met Leu Glu Lys 
    770                 775                 780                 


Arg Ala Lys Val Ile Glu Glu Leu Leu Gln Thr Glu Arg Asp Tyr Ile 
785                 790                 795                 800 


Arg Asp Leu Glu Met Cys Ile Glu Arg Ile Met Val Pro Met Gln Gln 
                805                 810                 815     


Ala Gln Val Pro Asn Ile Asp Phe Glu Gly Leu Phe Gly Asn Met Gln 
            820                 825                 830         


Met Val Ile Lys Val Ser Lys Gln Leu Leu Ala Ala Leu Glu Ile Ser 
        835                 840                 845             


Asp Ala Val Gly Pro Val Phe Leu Gly His Arg Asp Glu Leu Glu Gly 
    850                 855                 860                 


Thr Tyr Lys Ile Tyr Cys Gln Asn His Asp Glu Ala Ile Ala Leu Leu 
865                 870                 875                 880 


Glu Ile Tyr Glu Lys Asp Glu Lys Ile Gln Lys His Leu Gln Asp Ser 
                885                 890                 895     


Leu Ala Asp Leu Lys Ser Leu Tyr Asn Glu Trp Gly Cys Thr Asn Tyr 
            900                 905                 910         


Ile Asn Leu Gly Ser Phe Leu Ile Lys Pro Val Gln Arg Val Met Arg 
        915                 920                 925             


Tyr Pro Leu Leu Leu Met Glu Leu Leu Asn Ser Thr Pro Glu Ser His 
    930                 935                 940                 


Pro Asp Lys Val Pro Leu Thr Asn Ala Val Leu Ala Val Lys Glu Ile 
945                 950                 955                 960 


Asn Val Asn Ile Asn Glu Tyr Lys Arg Arg Lys Asp Leu Gly Lys Asn 
                965                 970                 975     


Ser Ile Ile Ala Glu Lys Glu Tyr Ala His Ala Glu Glu Ser Ala Phe 
            980                 985                 990         


Leu Thr Tyr Ser Leu Val Leu Lys  Tyr Arg Lys Gly Asp  Glu Asp Ser 
        995                 1000                 1005             


Leu Met  Glu Lys Ile Ser Lys  Leu Asn Ile His Ser  Ile Ile Lys 
    1010                 1015                 1020             


Lys Ser  Asn Arg Val Ser Ser  His Leu Lys His Leu  Thr Gly Phe 
    1025                 1030                 1035             


Ala Pro  Gln Ile Lys Asp Glu  Val Phe Glu Glu Thr  Glu Lys Asn 
    1040                 1045                 1050             


Phe Arg  Met Gln Glu Arg Leu  Ile Lys Ser Phe Ile  Arg Asp Leu 
    1055                 1060                 1065             


Ser Leu  Tyr Leu Gln His Ile  Arg Glu Ser Ala Cys  Val Lys Val 
    1070                 1075                 1080             


Val Ala  Ala Val Ser Met Trp  Asp Val Cys Met Glu  Arg Gly His 
    1085                 1090                 1095             


Arg Asp  Leu Glu Gln Phe Glu  Arg Val His Arg Tyr  Ile Ser Asp 
    1100                 1105                 1110             


Gln Leu  Phe Thr Asn Phe Lys  Glu Arg Thr Glu Arg  Leu Val Ile 
    1115                 1120                 1125             


Ser Pro  Leu Asn Gln Leu Leu  Ser Met Phe Thr Gly  Pro His Lys 
    1130                 1135                 1140             


Leu Val  Gln Lys Arg Phe Asp  Lys Leu Leu Asp Phe  Tyr Asn Cys 
    1145                 1150                 1155             


Thr Glu  Arg Ala Glu Lys Leu  Lys Asp Lys Lys Thr  Leu Glu Glu 
    1160                 1165                 1170             


Leu Gln  Ser Ala Arg Asn Asn  Tyr Glu Ala Leu Asn  Ala Gln Leu 
    1175                 1180                 1185             


Leu Asp  Glu Leu Pro Lys Phe  His Gln Tyr Ala Gln  Gly Leu Phe 
    1190                 1195                 1200             


Thr Asn  Cys Val His Gly Tyr  Ala Glu Ala His Cys  Asp Phe Val 
    1205                 1210                 1215             


His Gln  Ala Leu Glu Gln Leu  Lys Pro Leu Leu Ser  Leu Leu Lys 
    1220                 1225                 1230             


Val Ala  Gly Arg Glu Gly Asn  Leu Ile Ala Ile Phe  His Glu Glu 
    1235                 1240                 1245             


His Ser  Arg Val Leu Gln Gln  Leu Gln Val Phe Thr  Phe Phe Pro 
    1250                 1255                 1260             


Glu Ser  Leu Pro Ala Thr Lys  Lys Pro Phe Glu Arg  Lys Thr Ile 
    1265                 1270                 1275             


Asp Arg  Gln Ser Ala Arg Lys  Pro Leu Leu Gly Leu  Pro Ser Tyr 
    1280                 1285                 1290             


Met Leu  Gln Ser Glu Glu Leu  Arg Ala Ser Leu Leu  Ala Arg Tyr 
    1295                 1300                 1305             


Pro Pro  Glu Lys Leu Phe Gln  Ala Glu Arg Asn Phe  Asn Ala Ala 
    1310                 1315                 1320             


Gln Asp  Leu Asp Val Ser Leu  Leu Glu Gly Asp Leu  Val Gly Val 
    1325                 1330                 1335             


Ile Lys  Lys Lys Asp Pro Met  Gly Ser Gln Asn Arg  Trp Leu Ile 
    1340                 1345                 1350             


Asp Asn  Gly Val Thr Lys Gly  Phe Val Tyr Ser Ser  Phe Leu Lys 
    1355                 1360                 1365             


Pro Tyr  Asn Pro Arg Arg Ser  His Ser Asp Ala Ser  Val Gly Ser 
    1370                 1375                 1380             


His Ser  Ser Thr Glu Ser Glu  His Gly Ser Ser Ser  Pro Arg Phe 
    1385                 1390                 1395             


Pro Arg  Gln Asn Ser Gly Ser  Thr Leu Thr Phe Asn  Pro Ser Ser 
    1400                 1405                 1410             


Met Ala  Val Ser Phe Thr Ser  Gly Ser Cys Gln Lys  Gln Pro Gln 
    1415                 1420                 1425             


Asp Ala  Ser Pro Pro Pro Lys  Glu Cys Asp Gln Gly  Thr Leu Ser 
    1430                 1435                 1440             


Ala Ser  Leu Asn Pro Ser Asn  Ser Glu Ser Ser Pro  Ser Arg Cys 
    1445                 1450                 1455             


Pro Ser  Asp Pro Asp Ser Thr  Ser Gln Pro Arg Ser  Gly Asp Ser 
    1460                 1465                 1470             


Ala Asp  Val Ala Arg Asp Val  Lys Gln Pro Thr Ala  Thr Pro Arg 
    1475                 1480                 1485             


Ser Tyr  Arg Asn Phe Arg His  Pro Glu Ile Val Gly  Tyr Ser Val 
    1490                 1495                 1500             


Pro Gly  Arg Asn Gly Gln Ser  Gln Asp Leu Val Lys  Gly Cys Ala 
    1505                 1510                 1515             


Arg Thr  Ala Gln Ala Pro Glu  Asp Arg Ser Thr Glu  Pro Asp Gly 
    1520                 1525                 1530             


Ser Glu  Ala Glu Gly Asn Gln  Val Tyr Phe Ala Val  Tyr Thr Phe 
    1535                 1540                 1545             


Lys Ala  Arg Asn Pro Asn Glu  Leu Ser Val Ser Ala  Asn Gln Lys 
    1550                 1555                 1560             


Leu Lys  Ile Leu Glu Phe Lys  Asp Val Thr Gly Asn  Thr Glu Trp 
    1565                 1570                 1575             


Trp Leu  Ala Glu Val Asn Gly  Lys Lys Gly Tyr Val  Pro Ser Asn 
    1580                 1585                 1590             


Tyr Ile  Arg Lys Thr Glu Tyr  Thr 
    1595                 1600     


<210> 5737
<211> 531
<212> PRT
<213> Homo sapiens

<400> 5737
Met Lys Cys His Tyr Glu Ala Leu Gly Val Arg Arg Asp Ala Ser Glu 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Leu Asp Asn Ala Ala Glu Ala Ala Glu Gln Phe Lys Leu 
        35                  40                  45              


Ile Gln Ala Ala Tyr Asp Val Leu Ser Asp Pro Gln Glu Arg Ala Trp 
    50                  55                  60                  


Tyr Asp Asn His Arg Glu Ala Leu Leu Lys Gly Gly Phe Asp Gly Glu 
65                  70                  75                  80  


Tyr Gln Asp Asp Ser Leu Asp Leu Leu Arg Tyr Phe Thr Val Thr Cys 
                85                  90                  95      


Tyr Ser Gly Tyr Gly Asp Asp Glu Lys Gly Phe Tyr Thr Val Tyr Arg 
            100                 105                 110         


Asn Val Phe Glu Met Ile Ala Lys Glu Glu Leu Glu Ser Val Leu Glu 
        115                 120                 125             


Glu Glu Val Asp Asp Phe Pro Thr Phe Gly Asp Ser Gln Ser Asp Tyr 
    130                 135                 140                 


Asp Thr Val Val His Pro Phe Tyr Ala Tyr Trp Gln Ser Phe Cys Thr 
145                 150                 155                 160 


Gln Lys Asn Phe Ala Trp Lys Glu Glu Tyr Asp Thr Arg Gln Ala Ser 
                165                 170                 175     


Asn Arg Trp Glu Lys Arg Ala Met Glu Lys Glu Asn Lys Lys Ile Arg 
            180                 185                 190         


Asp Lys Ala Arg Lys Glu Lys Asn Glu Leu Val Arg Gln Leu Val Ala 
        195                 200                 205             


Phe Ile Arg Lys Arg Asp Lys Arg Val Gln Ala His Arg Lys Leu Val 
    210                 215                 220                 


Glu Glu Gln Asn Ala Glu Lys Ala Arg Lys Ala Glu Glu Met Arg Arg 
225                 230                 235                 240 


Gln Gln Lys Leu Lys Gln Ala Lys Leu Val Glu Gln Tyr Arg Glu Gln 
                245                 250                 255     


Ser Trp Met Thr Met Ala Asn Leu Glu Lys Glu Leu Gln Glu Met Glu 
            260                 265                 270         


Ala Arg Tyr Glu Lys Glu Phe Gly Asp Gly Ser Asp Glu Asn Glu Met 
        275                 280                 285             


Glu Glu His Glu Leu Lys Asp Glu Glu Asp Gly Lys Asp Ser Asp Glu 
    290                 295                 300                 


Ala Glu Asp Ala Glu Leu Tyr Asp Asp Leu Tyr Cys Pro Ala Cys Asp 
305                 310                 315                 320 


Lys Ser Phe Lys Thr Glu Lys Ala Met Lys Asn His Glu Lys Ser Lys 
                325                 330                 335     


Lys His Arg Glu Met Val Ala Leu Leu Lys Gln Gln Leu Glu Glu Glu 
            340                 345                 350         


Glu Glu Asn Phe Ser Arg Pro Gln Ile Asp Glu Asn Pro Leu Asp Asp 
        355                 360                 365             


Asn Ser Glu Glu Glu Met Glu Asp Ala Pro Lys Gln Lys Leu Ser Lys 
    370                 375                 380                 


Lys Gln Lys Lys Lys Lys Gln Lys Pro Ala Gln Asn Tyr Asp Asp Asn 
385                 390                 395                 400 


Phe Asn Val Asn Gly Pro Gly Glu Gly Val Lys Val Asp Pro Glu Asp 
                405                 410                 415     


Thr Asn Leu Asn Gln Asp Ser Ala Lys Glu Leu Glu Asp Ser Pro Gln 
            420                 425                 430         


Glu Asn Val Ser Val Thr Glu Ile Ile Lys Pro Cys Asp Asp Pro Lys 
        435                 440                 445             


Ser Glu Ala Lys Ser Val Pro Lys Pro Lys Gly Lys Lys Thr Lys Asp 
    450                 455                 460                 


Met Lys Lys Pro Val Arg Val Pro Ala Glu Pro Gln Thr Met Ser Val 
465                 470                 475                 480 


Leu Ile Ser Cys Thr Thr Cys His Ser Glu Phe Pro Ser Arg Asn Lys 
                485                 490                 495     


Leu Phe Asp His Leu Lys Ala Thr Gly His Ala Arg Ala Pro Ser Ser 
            500                 505                 510         


Ser Ser Leu Asn Ser Ala Thr Ser Ser Gln Ser Lys Lys Glu Lys Arg 
        515                 520                 525             


Lys Asn Arg 
    530     


<210> 5738
<211> 450
<212> PRT
<213> Homo sapiens

<400> 5738
Met Val Val Gln Ala Ala Val Ala Pro Asn Arg Ser Gln Arg Leu Leu 
1               5                   10                  15      


Leu Lys Ile Pro Tyr Gly Ser Leu Arg Arg Arg Ser Val Glu Arg Met 
            20                  25                  30          


Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys Leu 
        35                  40                  45              


Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp Leu 
    50                  55                  60                  


Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Ala 
65                  70                  75                  80  


Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg Arg 
                85                  90                  95      


Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu Tyr 
            100                 105                 110         


Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp Asn 
        115                 120                 125             


Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr Lys 
    130                 135                 140                 


Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser Tyr 
145                 150                 155                 160 


Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val Arg 
                165                 170                 175     


Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys Glu 
            180                 185                 190         


His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr Lys 
        195                 200                 205             


Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met Ser 
    210                 215                 220                 


Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val Lys 
225                 230                 235                 240 


Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly Ile 
                245                 250                 255     


Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe Gln 
            260                 265                 270         


Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser Val 
        275                 280                 285             


Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe Gly 
    290                 295                 300                 


His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu Ile 
305                 310                 315                 320 


Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp 
                325                 330                 335     


Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser Glu 
            340                 345                 350         


Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys Leu 
        355                 360                 365             


Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly Ser 
    370                 375                 380                 


Leu Leu Ser Ser Gly Arg Gln Arg Pro Ala Gly Gly Thr Pro Pro Glu 
385                 390                 395                 400 


His Gly Trp Asp Pro Arg Gly Asp Pro Gly Arg Trp Gly Glu Leu Gln 
                405                 410                 415     


Leu Gly Arg Leu Gln Gly Lys Leu Leu Gln Ser Trp Leu Cys Phe Pro 
            420                 425                 430         


Asp Gln Gly Trp Asp Pro Asn Ala Asn Leu Arg Lys Leu Leu Pro Gly 
        435                 440                 445             


Ile Lys 
    450 


<210> 5739
<211> 339
<212> PRT
<213> Homo sapiens

<400> 5739
Met Glu Gly Glu Pro Pro Pro Val Glu Glu Arg Arg Arg Leu Gln Glu 
1               5                   10                  15      


Glu Leu Asn Glu Phe Val Glu Ser Gly Cys Arg Thr Leu Glu Glu Val 
            20                  25                  30          


Thr Ala Ser Leu Gly Trp Asp Leu Asp Ser Leu Asp Pro Gly Glu Glu 
        35                  40                  45              


Glu Ala Ala Glu Asp Glu Val Val Ile Cys Pro Tyr Asp Ser Asn His 
    50                  55                  60                  


His Met Pro Lys Ser Ser Leu Ala Lys His Met Ala Ser Cys Arg Leu 
65                  70                  75                  80  


Arg Lys Met Gly Tyr Thr Lys Glu Glu Glu Asp Glu Met Tyr Asn Pro 
                85                  90                  95      


Glu Phe Phe Tyr Glu Asn Val Lys Ile Pro Ser Ile Thr Leu Asn Lys 
            100                 105                 110         


Asp Ser Gln Phe Gln Ile Ile Lys Gln Ala Arg Thr Ala Val Gly Lys 
        115                 120                 125             


Asp Ser Asp Cys Tyr Asn Gln Arg Ile Tyr Ser Ser Leu Pro Val Glu 
    130                 135                 140                 


Val Pro Leu Asn His Lys Arg Phe Val Cys Asp Leu Thr Gln Ala Asp 
145                 150                 155                 160 


Arg Leu Ala Leu Tyr Asp Phe Val Val Glu Glu Thr Lys Lys Lys Arg 
                165                 170                 175     


Ser Asp Ser Gln Ile Ile Glu Asn Asp Ser Asp Leu Phe Val Asp Leu 
            180                 185                 190         


Ala Ala Lys Ile Asn Gln Asp Asn Ser Arg Lys Ser Pro Lys Ser Tyr 
        195                 200                 205             


Leu Glu Ile Leu Ala Glu Val Arg Asp Tyr Lys Arg Arg Arg Gln Ser 
    210                 215                 220                 


Tyr Arg Ala Lys Asn Val His Ile Thr Lys Lys Ser Tyr Thr Glu Val 
225                 230                 235                 240 


Ile Arg Asp Val Ile Asn Val His Met Glu Glu Leu Ser Asn His Trp 
                245                 250                 255     


Gln Glu Glu Gln Glu Lys Ala Glu Asp Asp Ala Glu Lys Asn Glu Glu 
            260                 265                 270         


Arg Arg Ser Ala Ser Val Asp Ser Arg Gln Ser Gly Gly Ser Tyr Leu 
        275                 280                 285             


Asp Ala Glu Cys Ser Arg His Arg Arg Asp Arg Ser Arg Ser Pro His 
    290                 295                 300                 


Lys Arg Lys Arg Asn Lys Asp Lys Asp Lys Asn Cys Glu Ser Arg Arg 
305                 310                 315                 320 


Arg Lys Glu Arg Asp Gly Glu Arg His His Ser His Lys Arg Arg Lys 
                325                 330                 335     


Gln Lys Ile 
            


<210> 5740
<211> 2269
<212> PRT
<213> Homo sapiens

<400> 5740
Met Ala Glu Pro Ser Ser Ala Arg Arg Pro Val Pro Leu Ile Glu Ser 
1               5                   10                  15      


Glu Leu Tyr Phe Leu Ile Ala Arg Tyr Leu Ser Ala Gly Pro Cys Arg 
            20                  25                  30          


Arg Ala Ala Gln Val Leu Val Gln Glu Leu Glu Gln Tyr Gln Leu Leu 
        35                  40                  45              


Pro Lys Arg Leu Asp Trp Glu Gly Asn Glu His Asn Arg Ser Tyr Glu 
    50                  55                  60                  


Glu Leu Val Leu Ser Asn Lys His Val Ala Pro Asp His Leu Leu Gln 
65                  70                  75                  80  


Ile Cys Gln Arg Ile Gly Pro Met Leu Asp Lys Glu Ile Pro Pro Ser 
                85                  90                  95      


Ile Ser Arg Val Thr Ser Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu 
            100                 105                 110         


Arg Thr Ala Lys Asp Cys Arg His Thr Val Trp Lys Gly Ser Ala Phe 
        115                 120                 125             


Ala Ala Leu His Arg Gly Arg Pro Pro Glu Met Pro Val Asn Tyr Gly 
    130                 135                 140                 


Ser Pro Pro Asn Leu Val Glu Ile His Arg Gly Lys Gln Leu Thr Gly 
145                 150                 155                 160 


Cys Ser Thr Phe Ser Thr Ala Phe Pro Gly Thr Met Tyr Gln His Ile 
                165                 170                 175     


Lys Met His Arg Arg Ile Leu Gly His Leu Ser Ala Val Tyr Cys Val 
            180                 185                 190         


Ala Phe Asp Arg Thr Gly His Arg Ile Phe Thr Gly Ser Asp Asp Cys 
        195                 200                 205             


Leu Val Lys Ile Trp Ser Thr His Asn Gly Arg Leu Leu Ser Thr Leu 
    210                 215                 220                 


Arg Gly His Ser Ala Glu Ile Ser Asp Met Ala Val Asn Tyr Glu Asn 
225                 230                 235                 240 


Thr Met Ile Ala Ala Gly Ser Cys Asp Lys Ile Ile Arg Val Trp Cys 
                245                 250                 255     


Leu Arg Thr Cys Ala Pro Val Ala Val Leu Gln Gly His Thr Gly Ser 
            260                 265                 270         


Ile Thr Ser Leu Gln Phe Ser Pro Met Ala Lys Gly Ser Gln Arg Tyr 
        275                 280                 285             


Met Val Ser Thr Gly Ala Asp Gly Thr Val Cys Phe Trp Gln Trp Asp 
    290                 295                 300                 


Leu Glu Ser Leu Lys Phe Ser Pro Arg Pro Leu Lys Phe Thr Glu Lys 
305                 310                 315                 320 


Pro Arg Pro Gly Val Gln Met Leu Cys Ser Ser Phe Ser Val Gly Gly 
                325                 330                 335     


Met Phe Leu Ala Thr Gly Ser Thr Asp His Val Ile Arg Met Tyr Phe 
            340                 345                 350         


Leu Gly Phe Glu Ala Pro Glu Lys Ile Ala Glu Leu Glu Ser His Thr 
        355                 360                 365             


Asp Lys Val Asp Ser Ile Gln Phe Cys Asn Asn Gly Asp Arg Phe Leu 
    370                 375                 380                 


Ser Gly Ser Arg Asp Gly Thr Ala Arg Ile Trp Arg Phe Glu Gln Leu 
385                 390                 395                 400 


Glu Trp Arg Ser Ile Leu Leu Asp Met Ala Thr Arg Ile Ser Gly Asp 
                405                 410                 415     


Leu Ser Ser Glu Glu Glu Arg Phe Met Lys Pro Lys Val Thr Met Ile 
            420                 425                 430         


Ala Trp Asn Gln Asn Asp Ser Ile Val Val Thr Ala Val Asn Asp His 
        435                 440                 445             


Val Leu Lys Val Trp Asn Ser Tyr Thr Gly Gln Leu Leu His Asn Leu 
    450                 455                 460                 


Met Gly His Ala Asp Glu Val Phe Val Leu Glu Thr His Pro Phe Asp 
465                 470                 475                 480 


Ser Arg Ile Met Leu Ser Ala Gly His Asp Gly Ser Ile Phe Ile Trp 
                485                 490                 495     


Asp Ile Thr Lys Gly Thr Lys Met Lys His Tyr Phe Asn Met Ile Glu 
            500                 505                 510         


Gly Gln Gly His Gly Ala Val Phe Asp Cys Lys Phe Ser Gln Asp Gly 
        515                 520                 525             


Gln His Phe Ala Cys Thr Asp Ser His Gly His Leu Leu Ile Phe Gly 
    530                 535                 540                 


Phe Gly Cys Ser Lys Pro Tyr Glu Lys Ile Pro Asp Gln Met Phe Phe 
545                 550                 555                 560 


His Thr Asp Tyr Arg Pro Leu Ile Arg Asp Ser Asn Asn Tyr Val Leu 
                565                 570                 575     


Asp Glu Gln Thr Gln Gln Ala Pro His Leu Met Pro Pro Pro Phe Leu 
            580                 585                 590         


Val Asp Val Asp Gly Asn Pro His Pro Thr Lys Tyr Gln Arg Leu Val 
        595                 600                 605             


Pro Gly Arg Glu Asn Ser Ala Asp Glu His Leu Ile Pro Gln Leu Gly 
    610                 615                 620                 


Tyr Val Ala Thr Ser Asp Gly Glu Val Ile Glu Gln Ile Ile Ser Leu 
625                 630                 635                 640 


Gln Thr Asn Asp Asn Asp Glu Arg Ser Pro Glu Ser Ser Ile Leu Asp 
                645                 650                 655     


Gly Met Ile Arg Gln Leu Gln Gln Gln Gln Asp Gln Arg Met Gly Ala 
            660                 665                 670         


Asp Gln Asp Thr Ile Pro Arg Gly Leu Ser Asn Gly Glu Glu Thr Pro 
        675                 680                 685             


Arg Arg Gly Phe Arg Arg Leu Ser Leu Asp Ile Gln Ser Pro Pro Asn 
    690                 695                 700                 


Ile Gly Leu Arg Arg Ser Gly Gln Val Glu Gly Val Arg Gln Met His 
705                 710                 715                 720 


Gln Asn Ala Pro Arg Ser Gln Ile Ala Thr Glu Arg Asp Leu Gln Ala 
                725                 730                 735     


Trp Lys Arg Arg Val Val Val Pro Glu Val Pro Leu Gly Ile Phe Arg 
            740                 745                 750         


Lys Leu Glu Asp Phe Arg Leu Glu Lys Gly Glu Glu Glu Arg Asn Leu 
        755                 760                 765             


Tyr Ile Ile Gly Arg Lys Arg Lys Thr Leu Gln Leu Ser His Lys Ser 
    770                 775                 780                 


Asp Ser Val Val Leu Val Ser Gln Ser Arg Gln Arg Thr Cys Arg Arg 
785                 790                 795                 800 


Lys Tyr Pro Asn Tyr Gly Arg Arg Asn Arg Ser Trp Arg Glu Leu Ser 
                805                 810                 815     


Ser Gly Asn Glu Ser Ser Ser Ser Val Arg His Glu Thr Ser Cys Asp 
            820                 825                 830         


Gln Ser Glu Gly Ser Gly Ser Ser Glu Glu Asp Glu Trp Arg Ser Asp 
        835                 840                 845             


Arg Lys Ser Glu Ser Tyr Ser Glu Ser Ser Ser Asp Ser Ser Ser Arg 
    850                 855                 860                 


Tyr Ser Asp Trp Thr Ala Asp Ala Gly Ile Asn Leu Gln Pro Pro Leu 
865                 870                 875                 880 


Arg Thr Ser Cys Arg Arg Arg Ile Thr Arg Phe Cys Ser Ser Ser Glu 
                885                 890                 895     


Asp Glu Ile Ser Thr Glu Asn Leu Ser Pro Pro Lys Arg Arg Arg Lys 
            900                 905                 910         


Arg Lys Lys Glu Asn Lys Pro Lys Lys Glu Asn Leu Arg Arg Met Thr 
        915                 920                 925             


Pro Ala Glu Leu Ala Asn Met Glu His Leu Tyr Glu Phe His Pro Pro 
    930                 935                 940                 


Val Trp Ile Thr Asp Thr Thr Leu Arg Lys Ser Pro Phe Val Pro Gln 
945                 950                 955                 960 


Met Gly Asp Glu Val Ile Tyr Phe Arg Gln Gly His Glu Ala Tyr Ile 
                965                 970                 975     


Glu Ala Val Arg Arg Asn Asn Ile Tyr Glu Leu Asn Pro Asn Lys Glu 
            980                 985                 990         


Pro Trp Arg Lys Met Asp Leu Arg  Asp Gln Glu Leu Val  Lys Ile Val 
        995                 1000                 1005             


Gly Ile  Arg Tyr Glu Val Gly  Pro Pro Thr Leu Cys  Cys Leu Lys 
    1010                 1015                 1020             


Leu Ala  Phe Ile Asp Pro Ala  Thr Gly Lys Leu Met  Asp Lys Ser 
    1025                 1030                 1035             


Phe Ser  Ile Arg Tyr His Asp  Met Pro Asp Val Ile  Asp Phe Leu 
    1040                 1045                 1050             


Val Leu  Arg Gln Phe Tyr Asp  Glu Ala Arg Gln Arg  Asn Trp Gln 
    1055                 1060                 1065             


Ser Cys  Asp Arg Phe Arg Ser  Ile Ile Asp Asp Ala  Trp Trp Phe 
    1070                 1075                 1080             


Gly Thr  Val Leu Ser Gln Glu  Pro Tyr Gln Pro Gln  Tyr Pro Asp 
    1085                 1090                 1095             


Ser His  Phe Gln Cys Tyr Ile  Val Arg Trp Asp Asn  Thr Glu Ile 
    1100                 1105                 1110             


Glu Lys  Leu Ser Pro Trp Asp  Met Glu Pro Ile Pro  Asp Asn Val 
    1115                 1120                 1125             


Asp Pro  Pro Glu Glu Leu Gly  Ala Ser Ile Ser Val  Thr Thr Asp 
    1130                 1135                 1140             


Glu Leu  Glu Lys Leu Leu Tyr  Lys Pro Gln Ala Gly  Glu Trp Gly 
    1145                 1150                 1155             


Gln Lys  Ser Arg Asp Glu Glu  Cys Asp Arg Ile Ile  Ser Gly Ile 
    1160                 1165                 1170             


Asp Gln  Leu Leu Asn Leu Asp  Ile Ala Ala Ala Phe  Ala Gly Pro 
    1175                 1180                 1185             


Val Asp  Leu Cys Thr Tyr Pro  Lys Tyr Cys Thr Val  Val Ala Tyr 
    1190                 1195                 1200             


Pro Thr  Asp Leu Tyr Thr Ile  Arg Met Arg Leu Val  Asn Arg Phe 
    1205                 1210                 1215             


Tyr Arg  Arg Leu Ser Ala Leu  Val Trp Glu Val Arg  Tyr Ile Glu 
    1220                 1225                 1230             


His Asn  Ala Arg Thr Phe Asn  Glu Pro Glu Ser Val  Ile Ala Arg 
    1235                 1240                 1245             


Ser Ala  Lys Lys Ile Thr Asp  Gln Leu Leu Lys Phe  Ile Lys Asn 
    1250                 1255                 1260             


Gln His  Cys Thr Asn Ile Ser  Glu Leu Ser Asn Thr  Ser Glu Asn 
    1265                 1270                 1275             


Asp Glu  Gln Asn Ala Glu Asp  Leu Asp Asp Ser Asp  Leu Pro Lys 
    1280                 1285                 1290             


Thr Ser  Ser Gly Arg Arg Arg  Val His Asp Gly Lys  Lys Ser Ile 
    1295                 1300                 1305             


Arg Ala  Thr Asn Tyr Val Glu  Ser Asn Trp Lys Lys  Gln Cys Lys 
    1310                 1315                 1320             


Glu Leu  Val Asn Leu Ile Phe  Gln Cys Glu Asp Ser  Glu Pro Phe 
    1325                 1330                 1335             


Arg Gln  Pro Val Asp Leu Val  Glu Tyr Pro Asp Tyr  Arg Asp Ile 
    1340                 1345                 1350             


Ile Asp  Thr Pro Met Asp Phe  Gly Thr Val Arg Glu  Thr Leu Asp 
    1355                 1360                 1365             


Ala Gly  Asn Tyr Asp Ser Pro  Leu Glu Phe Cys Lys  Asp Ile Arg 
    1370                 1375                 1380             


Leu Ile  Phe Ser Asn Ala Lys  Ala Tyr Thr Pro Asn  Lys Arg Ser 
    1385                 1390                 1395             


Lys Ile  Tyr Ser Met Thr Leu  Arg Leu Ser Ala Leu  Phe Glu Glu 
    1400                 1405                 1410             


Lys Met  Lys Lys Ile Ser Ser  Asp Phe Lys Ile Gly  Gln Lys Phe 
    1415                 1420                 1425             


Asn Glu  Lys Leu Arg Arg Ser  Gln Arg Phe Lys Gln  Arg Gln Asn 
    1430                 1435                 1440             


Cys Lys  Gly Asp Ser Gln Pro  Asn Lys Ser Ile Arg  Asn Leu Lys 
    1445                 1450                 1455             


Pro Lys  Arg Leu Lys Ser Gln  Thr Lys Ile Ile Pro  Glu Leu Val 
    1460                 1465                 1470             


Gly Ser  Pro Thr Gln Ser Thr  Ser Ser Arg Thr Ala  Tyr Leu Gly 
    1475                 1480                 1485             


Thr His  Lys Thr Ser Ala Gly  Ile Ser Ser Gly Val  Thr Ser Gly 
    1490                 1495                 1500             


Asp Ser  Ser Asp Ser Ala Glu  Ser Ser Glu Arg Arg  Lys Arg Asn 
    1505                 1510                 1515             


Arg Pro  Ile Thr Asn Gly Ser  Thr Leu Ser Glu Ser  Glu Val Glu 
    1520                 1525                 1530             


Asp Ser  Leu Ala Thr Ser Leu  Ser Ser Ser Ala Ser  Ser Ser Ser 
    1535                 1540                 1545             


Glu Glu  Ser Lys Glu Ser Ser  Arg Ala Arg Glu Ser  Ser Ser Arg 
    1550                 1555                 1560             


Ser Gly  Leu Ser Arg Ser Ser  Asn Leu Arg Val Thr  Arg Thr Arg 
    1565                 1570                 1575             


Ala Ala  Gln Arg Lys Thr Gly  Pro Val Ser Leu Ala  Asn Gly Cys 
    1580                 1585                 1590             


Gly Arg  Lys Ala Thr Arg Lys  Arg Val Tyr Leu Ser  Asp Ser Asp 
    1595                 1600                 1605             


Asn Asn  Ser Leu Glu Thr Gly  Glu Ile Leu Lys Ala  Arg Ala Gly 
    1610                 1615                 1620             


Asn Asn  Arg Lys Val Leu Arg  Lys Cys Ala Ala Val  Ala Ala Asn 
    1625                 1630                 1635             


Lys Ile  Lys Leu Met Ser Asp  Val Glu Glu Asn Ser  Ser Ser Glu 
    1640                 1645                 1650             


Ser Val  Cys Ser Gly Arg Lys  Leu Pro His Arg Asn  Ala Ser Ala 
    1655                 1660                 1665             


Val Ala  Arg Lys Lys Leu Leu  His Asn Ser Glu Asp  Glu Gln Ser 
    1670                 1675                 1680             


Leu Lys  Ser Glu Ile Glu Glu  Glu Glu Leu Lys Asp  Glu Asn Gln 
    1685                 1690                 1695             


Leu Leu  Pro Val Ser Ser Ser  His Thr Ala Gln Ser  Asn Val Asp 
    1700                 1705                 1710             


Glu Ser  Glu Asn Arg Asp Ser  Glu Ser Glu Ser Asp  Leu Arg Val 
    1715                 1720                 1725             


Ala Arg  Lys Asn Trp His Ala  Asn Gly Tyr Lys Ser  His Thr Pro 
    1730                 1735                 1740             


Ala Pro  Ser Lys Thr Lys Phe  Leu Lys Ile Glu Ser  Ser Glu Glu 
    1745                 1750                 1755             


Asp Ser  Lys Ser His Asp Ser  Asp His Ala Cys Asn  Arg Thr Ala 
    1760                 1765                 1770             


Gly Pro  Ser Thr Ser Val Gln  Lys Leu Lys Ala Glu  Ser Ile Ser 
    1775                 1780                 1785             


Glu Glu  Ala Asp Ser Glu Pro  Gly Arg Ser Gly Gly  Arg Lys Tyr 
    1790                 1795                 1800             


Asn Thr  Phe His Lys Asn Ala  Ser Phe Phe Lys Lys  Thr Lys Ile 
    1805                 1810                 1815             


Leu Ser  Asp Ser Glu Asp Ser  Glu Ser Glu Glu Gln  Asp Arg Glu 
    1820                 1825                 1830             


Asp Gly  Lys Cys His Lys Met  Glu Met Asn Pro Ile  Ser Gly Asn 
    1835                 1840                 1845             


Leu Asn  Cys Asp Pro Ile Ala  Met Ser Gln Cys Ser  Ser Asp His 
    1850                 1855                 1860             


Gly Cys  Glu Thr Asp Leu Asp  Ser Asp Asp Asp Lys  Ile Glu Lys 
    1865                 1870                 1875             


Pro Asn  Asn Phe Met Lys Asp  Ser Ala Ser Gln Asp  Asn Gly Leu 
    1880                 1885                 1890             


Ser Arg  Lys Ile Ser Arg Lys  Arg Val Cys Ser Ser  Asp Ser Asp 
    1895                 1900                 1905             


Ser Ser  Leu Gln Val Val Lys  Lys Ser Ser Lys Ala  Arg Thr Gly 
    1910                 1915                 1920             


Leu Leu  Arg Ile Thr Arg Arg  Cys Ala Ala Thr Ala  Ala Asn Lys 
    1925                 1930                 1935             


Ile Lys  Leu Met Ser Asp Val  Glu Asp Val Ser Leu  Glu Asn Val 
    1940                 1945                 1950             


His Thr  Arg Ser Lys Asn Gly  Arg Lys Lys Pro Leu  His Leu Ala 
    1955                 1960                 1965             


Cys Thr  Thr Ala Lys Lys Lys  Leu Ser Asp Cys Glu  Gly Ser Val 
    1970                 1975                 1980             


His Cys  Glu Val Pro Ser Glu  Gln Tyr Ala Cys Glu  Gly Lys Pro 
    1985                 1990                 1995             


Pro Asp  Pro Asp Ser Glu Gly  Ser Thr Lys Val Leu  Ser Gln Ala 
    2000                 2005                 2010             


Leu Asn  Gly Asp Ser Asp Ser  Glu Asp Met Leu Asn  Ser Glu His 
    2015                 2020                 2025             


Lys His  Arg His Thr Asn Ile  His Lys Ile Asp Ala  Pro Ser Lys 
    2030                 2035                 2040             


Arg Lys  Ser Ser Ser Val Thr  Ser Ser Gly Glu Asp  Ser Lys Ser 
    2045                 2050                 2055             


His Ile  Pro Gly Ser Glu Thr  Asp Arg Thr Phe Ser  Ser Glu Ser 
    2060                 2065                 2070             


Thr Leu  Ala Gln Lys Ala Thr  Ala Glu Asn Asn Phe  Glu Val Glu 
    2075                 2080                 2085             


Leu Asn  Tyr Gly Leu Arg Arg  Trp Asn Gly Arg Arg  Leu Arg Thr 
    2090                 2095                 2100             


Tyr Gly  Lys Ala Pro Phe Ser  Lys Thr Lys Val Ile  His Asp Ser 
    2105                 2110                 2115             


Gln Glu  Thr Ala Glu Lys Glu  Val Lys Arg Lys Arg  Ser His Pro 
    2120                 2125                 2130             


Glu Leu  Glu Asn Val Lys Ile  Ser Glu Thr Thr Gly  Asn Ser Lys 
    2135                 2140                 2145             


Phe Arg  Pro Asp Thr Ser Ser  Lys Ser Ser Asp Leu  Gly Ser Val 
    2150                 2155                 2160             


Thr Glu  Ser Asp Ile Asp Cys  Thr Asp Asn Thr Lys  Thr Lys Arg 
    2165                 2170                 2175             


Arg Lys  Thr Lys Gly Lys Ala  Lys Val Val Arg Lys  Gly Lys Thr 
    2180                 2185                 2190             


Phe Thr  Ala Asn Ile Ser Lys  Thr Val Arg Arg Gln  Arg Gln Ser 
    2195                 2200                 2205             


Lys Arg  Pro Arg Leu Ser Val  Asp Asp Asn Asp Trp  Glu Asp Leu 
    2210                 2215                 2220             


Asp Tyr  Ala Lys Ser Lys Arg  Val Leu Arg Arg Ser  Lys Ile Lys 
    2225                 2230                 2235             


Thr Arg  Asn Gln Gly Arg Arg  Thr Val Arg Tyr His  Asp Gly Asp 
    2240                 2245                 2250             


Asp Asp  Arg Ser Leu Glu Asn  Val Leu Asp Phe Asn  Gly Cys Thr 
    2255                 2260                 2265             


Leu 
    


<210> 5741
<211> 163
<212> PRT
<213> Homo sapiens

<400> 5741
Met Thr Ala Pro Ser Cys Ala Phe Pro Val Gln Phe Arg Gln Pro Ser 
1               5                   10                  15      


Val Ser Gly Leu Ser Gln Ile Thr Lys Ser Leu Tyr Ile Ser Asn Gly 
            20                  25                  30          


Val Ala Ala Asn Asn Lys Leu Met Leu Ser Ser Asn Gln Ile Thr Met 
        35                  40                  45              


Val Ile Asn Val Ser Val Glu Val Val Asn Thr Leu Tyr Glu Asp Ile 
    50                  55                  60                  


Gln Tyr Met Gln Val Pro Val Ala Asp Ser Pro Asn Ser Arg Leu Cys 
65                  70                  75                  80  


Asp Phe Phe Asp Pro Ile Ala Asp His Ile His Ser Val Glu Met Lys 
                85                  90                  95      


Gln Gly Arg Thr Leu Leu His Cys Ala Ala Gly Val Ser Arg Ser Ala 
            100                 105                 110         


Ala Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ala Met Ser Leu Leu 
        115                 120                 125             


Asp Ala His Thr Trp Thr Lys Ser Cys Arg Pro Ile Ile Arg Pro Asn 
    130                 135                 140                 


Ser Gly Phe Trp Glu Gln Leu Ile His Tyr Glu Phe Gln Leu Phe Gly 
145                 150                 155                 160 


Lys Asn Thr 
            


<210> 5742
<211> 251
<212> PRT
<213> Homo sapiens

<400> 5742
Met Ile Ser Thr Thr Ser Lys Glu Thr Lys Lys Asp Thr Lys Leu Tyr 
1               5                   10                  15      


Cys Ile Cys Lys Thr Pro Tyr Asp Glu Ser Lys Phe Tyr Ile Gly Cys 
            20                  25                  30          


Asp Leu Cys Thr Asn Trp Tyr His Gly Glu Cys Val Gly Ile Thr Glu 
        35                  40                  45              


Lys Glu Ala Lys Lys Met Asp Val Tyr Ile Cys Asn Asp Cys Lys Arg 
    50                  55                  60                  


Ala Gln Glu Gly Ser Ser Glu Glu Leu Tyr Cys Ile Cys Arg Thr Pro 
65                  70                  75                  80  


Tyr Asp Glu Ser Gln Phe Tyr Ile Gly Cys Asp Arg Cys Gln Asn Trp 
                85                  90                  95      


Tyr His Gly Arg Cys Val Gly Ile Leu Gln Ser Glu Ala Glu Leu Ile 
            100                 105                 110         


Asp Glu Tyr Val Cys Pro Gln Cys Gln Ser Thr Glu Asp Ala Met Thr 
        115                 120                 125             


Val Leu Thr Pro Leu Thr Glu Lys Asp Tyr Glu Gly Leu Lys Arg Val 
    130                 135                 140                 


Leu Arg Ser Leu Gln Ala His Lys Met Ala Trp Pro Phe Leu Glu Pro 
145                 150                 155                 160 


Val Asp Pro Asn Asp Ala Pro Asp Tyr Tyr Gly Val Ile Lys Glu Pro 
                165                 170                 175     


Met Asp Leu Ala Thr Met Glu Glu Arg Val Gln Arg Arg Tyr Tyr Glu 
            180                 185                 190         


Lys Leu Thr Glu Phe Val Ala Asp Met Thr Lys Ile Phe Asp Asn Cys 
        195                 200                 205             


Arg Tyr Tyr Asn Pro Ser Asp Ser Pro Phe Tyr Gln Cys Ala Glu Val 
    210                 215                 220                 


Leu Glu Ser Phe Phe Val Gln Lys Leu Lys Gly Phe Lys Ala Ser Arg 
225                 230                 235                 240 


Ser His Asn Asn Lys Leu Gln Ser Thr Ala Ser 
                245                 250     


<210> 5743
<211> 166
<212> PRT
<213> Homo sapiens

<400> 5743
Met Tyr Ser Leu Asn Gln Glu Ile Lys Ala Phe Ser Arg Asn Asn Leu 
1               5                   10                  15      


Arg Lys Gln Cys Thr Arg Val Thr Thr Leu Thr Gly Lys Lys Ile Ile 
            20                  25                  30          


Glu Thr Trp Lys Asp Ala Arg Ile His Val Val Glu Glu Val Glu Pro 
        35                  40                  45              


Ser Ser Gly Gly Gly Cys Gly Tyr Val Gln Asp Leu Ser Ser Asp Leu 
    50                  55                  60                  


Gln Val Gly Val Ile Lys Pro Trp Leu Leu Leu Gly Ser Gln Asp Ala 
65                  70                  75                  80  


Ala His Asp Leu Asp Thr Leu Lys Lys Asn Lys Asp Gly Val Val Leu 
                85                  90                  95      


Val His Cys Asn Ala Gly Val Ser Arg Ala Ala Ala Ile Val Ile Gly 
            100                 105                 110         


Phe Leu Met Asn Ser Glu Gln Thr Ser Phe Thr Ser Ala Phe Ser Leu 
        115                 120                 125             


Val Lys Asn Ala Arg Pro Ser Ile Cys Pro Asn Ser Gly Phe Met Glu 
    130                 135                 140                 


Gln Leu Arg Thr Tyr Gln Glu Gly Lys Glu Ser Asn Lys Cys Asp Arg 
145                 150                 155                 160 


Ile Gln Glu Asn Ser Ser 
                165     


<210> 5744
<211> 320
<212> PRT
<213> Homo sapiens

<400> 5744
Met Ser Lys Ser Ala Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Thr Thr Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Lys Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Pro Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Arg Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Asp 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Cys Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Val Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210> 5745
<211> 118
<212> PRT
<213> Homo sapiens

<400> 5745
Met Ser Leu Leu Asn Lys Pro Lys Ser Glu Met Thr Pro Glu Glu Leu 
1               5                   10                  15      


Gln Lys Arg Glu Glu Glu Glu Phe Asn Thr Gly Pro Leu Ser Val Leu 
            20                  25                  30          


Thr Gln Ser Val Lys Asn Asn Thr Gln Val Leu Ile Asn Cys Arg Asn 
        35                  40                  45              


Asn Lys Lys Leu Leu Gly Arg Val Lys Ala Phe Asp Arg His Cys Asn 
    50                  55                  60                  


Met Val Leu Glu Asn Val Lys Glu Met Trp Thr Glu Val Pro Lys Ser 
65                  70                  75                  80  


Gly Lys Gly Lys Lys Lys Ser Lys Pro Val Asn Lys Asp Arg Tyr Ile 
                85                  90                  95      


Ser Lys Met Phe Leu Arg Gly Asp Ser Val Ile Val Val Leu Arg Asn 
            100                 105                 110         


Pro Leu Ile Ala Gly Lys 
        115             


<210> 5746
<211> 392
<212> PRT
<213> Homo sapiens

<400> 5746
Met Lys Asp Thr Leu Gly Gln Ala Gln Gln Arg Val Ala Glu Leu Glu 
1               5                   10                  15      


Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala Ala Ser Ser 
            20                  25                  30          


Gln Gln Lys Ala Thr Leu Leu Gly Glu Glu Leu Ala Ser Ala Ala Ala 
        35                  40                  45              


Ala Arg Asp Arg Thr Ile Ala Glu Leu His Arg Ser Arg Leu Glu Val 
    50                  55                  60                  


Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His Leu Lys Glu 
65                  70                  75                  80  


Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu Gln Ser Val 
                85                  90                  95      


Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu Ile Leu Arg 
            100                 105                 110         


Leu Glu Lys Ala Val Gln Glu Glu Arg Thr Gln Asn Gln Val Phe Lys 
        115                 120                 125             


Thr Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln Leu Ser Glu 
    130                 135                 140                 


Ser Lys Arg Glu Leu Thr Glu Leu Arg Ser Ala Leu Arg Val Leu Gln 
145                 150                 155                 160 


Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu Leu Glu Tyr 
                165                 170                 175     


Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp Glu Lys Trp 
            180                 185                 190         


Asn Glu Asp Ala Thr Thr Glu Asp Glu Glu Ala Ala Val Gly Leu Ser 
        195                 200                 205             


Cys Pro Ala Ala Leu Thr Asp Ser Glu Asp Glu Ser Pro Glu Asp Met 
    210                 215                 220                 


Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro Gly Ser Ser 
225                 230                 235                 240 


Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile Ser Gln Pro 
                245                 250                 255     


Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp Ser Ser Ser 
            260                 265                 270         


Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala Ala Val Gln 
        275                 280                 285             


Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu Gly Ser Ala 
    290                 295                 300                 


Phe Tyr Asp Met Ala Ser Thr Ile Phe Cys Arg Ala Gln Ile Ala Leu 
305                 310                 315                 320 


Leu Pro Leu Ser Pro Ala Ser Thr Pro Ser Pro Thr Thr Ser Gly Phe 
                325                 330                 335     


Thr Val Gly Thr Leu Ser Glu Thr Ser Thr Gly Gly Pro Ala Thr Pro 
            340                 345                 350         


Thr Trp Lys Glu Cys Pro Ile Cys Lys Glu Arg Phe Pro Ala Glu Ser 
        355                 360                 365             


Asp Lys Asp Ala Leu Glu Asp His Met Asp Gly His Phe Phe Phe Ser 
    370                 375                 380                 


Thr Gln Asp Pro Phe Thr Phe Glu 
385                 390         


<210> 5747
<211> 199
<212> PRT
<213> Homo sapiens

<400> 5747
Met Thr Pro Leu Ala Pro Trp Asp Pro Lys Tyr Glu Ala Lys Ala Gly 
1               5                   10                  15      


Pro Arg Pro Val Trp Gly Ala Asn Cys Ser Ser Gly Ala Ser Phe Ser 
            20                  25                  30          


Gly Arg Thr Leu Cys His Pro Ser Phe Trp Pro Leu Tyr Glu Ala Ala 
        35                  40                  45              


Ser Gly Arg Gly Leu Arg Pro Val Ala Pro Ala Thr Gly His Trp Asn 
    50                  55                  60                  


Gly Gln Gln Ala Pro Pro Asp Ala Gly Phe Pro Val Val Cys Cys Glu 
65                  70                  75                  80  


Asp Val Phe Leu Ser Asp Pro Leu Leu Pro Arg Gly Gln Arg Val Pro 
                85                  90                  95      


Leu Tyr Leu Ser Lys Ala Pro Gln Gln Met Met Gly Ser Leu Lys Leu 
            100                 105                 110         


Leu Pro Pro Pro Pro Ile Met Ser Ala Arg Val Leu Pro Arg Pro Ser 
        115                 120                 125             


Pro Ser Arg Gly Pro Ser Thr Ala Trp Leu Ser Gly Pro Glu Leu Ile 
    130                 135                 140                 


Ala Leu Thr Gly Leu Leu Gln Met Ser Gln Gly Glu Pro Arg Pro Ser 
145                 150                 155                 160 


Ser Ser Ala Val Gly Pro Pro Asp His Thr Ser Asp Pro Pro Ser Pro 
                165                 170                 175     


Cys Gly Ser Pro Ser Ser Ser Gln Gly Ala Asp Leu Ser Leu Pro Gln 
            180                 185                 190         


Thr Pro Asp Thr His Cys Pro 
        195                 


<210> 5748
<211> 384
<212> PRT
<213> Homo sapiens

<400> 5748
Met Glu Gly Leu Gly Arg Ser Cys Leu Trp Leu Arg Arg Glu Leu Ser 
1               5                   10                  15      


Pro Pro Arg Pro Arg Leu Leu Leu Leu Asp Cys Arg Ser Arg Glu Leu 
            20                  25                  30          


Tyr Glu Ser Ala Arg Ile Gly Gly Ala Leu Ser Val Ala Leu Pro Ala 
        35                  40                  45              


Leu Leu Leu Arg Arg Leu Arg Arg Gly Ser Leu Ser Val Arg Ala Leu 
    50                  55                  60                  


Leu Pro Gly Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro Val Leu Leu 
65                  70                  75                  80  


Tyr Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala Glu Ala Glu 
                85                  90                  95      


Ala Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu Leu Gln Lys 
            100                 105                 110         


Leu Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly Gly Phe Ser 
        115                 120                 125             


Arg Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser Leu Ala Gly 
    130                 135                 140                 


Arg Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val Pro Val Val 
145                 150                 155                 160 


Gly Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp Ala Glu Ser 
                165                 170                 175     


Glu Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser Glu Gly Ala 
            180                 185                 190         


Thr Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val Gln Ile Leu 
        195                 200                 205             


Pro Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn Leu Glu Ser 
    210                 215                 220                 


Leu Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr Pro Asn Leu 
225                 230                 235                 240 


Pro Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys Gln Ile Pro 
                245                 250                 255     


Ile Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe Pro Glu Ala 
            260                 265                 270         


Ile Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly Val Leu Val 
        275                 280                 285             


His Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr Val Ala Tyr 
    290                 295                 300                 


Leu Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr Asp Leu Val 
305                 310                 315                 320 


Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln 
                325                 330                 335     


Leu Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg His Ser Gln 
            340                 345                 350         


Glu Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn Pro Pro Ser 
        355                 360                 365             


Phe Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu Ala Pro Thr 
    370                 375                 380                 


<210> 5749
<211> 735
<212> PRT
<213> Homo sapiens

<400> 5749
Met Ala Glu Pro Leu Leu Arg Lys Thr Phe Ser Arg Leu Arg Gly Arg 
1               5                   10                  15      


Glu Lys Leu Pro Arg Lys Lys Ser Asp Ala Lys Glu Arg Gly His Pro 
            20                  25                  30          


Ala Gln Arg Pro Glu Pro Ser Pro Pro Glu Pro Glu Pro Gln Ala Pro 
        35                  40                  45              


Glu Gly Ser Gln Ala Gly Ala Glu Gly Pro Ser Ser Pro Glu Ala Ser 
    50                  55                  60                  


Arg Ser Pro Ala Arg Gly Ala Tyr Leu Gln Ser Leu Glu Pro Ser Ser 
65                  70                  75                  80  


Arg Arg Trp Val Leu Gly Gly Ala Lys Pro Ala Glu Asp Thr Ser Leu 
                85                  90                  95      


Gly Pro Gly Val Pro Gly Thr Gly Glu Pro Ala Gly Glu Ile Trp Tyr 
            100                 105                 110         


Asn Pro Ile Pro Glu Glu Asp Pro Arg Pro Pro Ala Pro Glu Pro Pro 
        115                 120                 125             


Gly Pro Gln Pro Gly Ser Ala Glu Ser Glu Gly Leu Ala Pro Gln Gly 
    130                 135                 140                 


Ala Ala Pro Ala Ser Pro Pro Thr Lys Ala Ser Arg Thr Lys Ser Pro 
145                 150                 155                 160 


Gly Pro Ala Arg Arg Leu Ser Ile Lys Met Lys Lys Leu Pro Glu Leu 
                165                 170                 175     


Arg Arg Arg Leu Ser Leu Arg Gly Pro Arg Ala Gly Arg Glu Arg Glu 
            180                 185                 190         


Arg Ala Ala Pro Ala Gly Ser Val Ile Ser Arg Tyr His Leu Asp Ser 
        195                 200                 205             


Ser Val Gly Gly Pro Gly Pro Ala Ala Gly Pro Gly Gly Thr Arg Ser 
    210                 215                 220                 


Pro Arg Ala Gly Tyr Leu Ser Asp Gly Asp Ser Pro Glu Arg Pro Ala 
225                 230                 235                 240 


Gly Pro Pro Ser Pro Thr Ser Phe Arg Pro Tyr Glu Val Gly Pro Ala 
                245                 250                 255     


Ala Arg Ala Pro Pro Ala Ala Leu Trp Gly Arg Leu Ser Leu His Leu 
            260                 265                 270         


Tyr Gly Leu Gly Gly Leu Arg Pro Ala Pro Gly Ala Thr Pro Arg Asp 
        275                 280                 285             


Leu Cys Cys Leu Leu Gln Val Asp Gly Glu Ala Arg Ala Arg Thr Gly 
    290                 295                 300                 


Pro Leu Arg Gly Gly Pro Asp Phe Leu Arg Leu Asp His Thr Phe His 
305                 310                 315                 320 


Leu Glu Leu Glu Ala Ala Arg Leu Leu Arg Ala Leu Val Leu Ala Trp 
                325                 330                 335     


Asp Pro Gly Val Arg Arg His Arg Pro Cys Ala Gln Gly Thr Val Leu 
            340                 345                 350         


Leu Pro Thr Val Phe Arg Gly Cys Gln Ala Gln Gln Leu Ala Val Arg 
        355                 360                 365             


Leu Glu Pro Gln Gly Leu Leu Tyr Ala Lys Leu Thr Leu Ser Glu Gln 
    370                 375                 380                 


Gln Glu Ala Pro Ala Thr Ala Glu Pro Arg Val Phe Gly Leu Pro Leu 
385                 390                 395                 400 


Pro Leu Leu Val Glu Arg Glu Arg Pro Pro Gly Gln Val Pro Leu Ile 
                405                 410                 415     


Ile Gln Lys Cys Val Gly Gln Ile Glu Arg Arg Gly Leu Arg Val Val 
            420                 425                 430         


Gly Leu Tyr Arg Leu Cys Gly Ser Ala Ala Val Lys Lys Glu Leu Arg 
        435                 440                 445             


Asp Ala Phe Glu Arg Asp Ser Ala Ala Val Cys Leu Ser Glu Asp Leu 
    450                 455                 460                 


Tyr Pro Asp Ile Asn Val Ile Thr Gly Ile Leu Lys Asp Tyr Leu Arg 
465                 470                 475                 480 


Glu Leu Pro Thr Pro Leu Ile Thr Gln Pro Leu Tyr Lys Val Val Leu 
                485                 490                 495     


Glu Ala Met Ala Arg Asp Pro Pro Asn Arg Val Pro Pro Thr Thr Glu 
            500                 505                 510         


Gly Thr Arg Gly Leu Leu Ser Cys Leu Pro Asp Val Glu Arg Ala Thr 
        515                 520                 525             


Leu Thr Leu Leu Leu Asp His Leu Arg Leu Val Ser Ser Phe His Ala 
    530                 535                 540                 


Tyr Asn Arg Met Thr Pro Gln Asn Leu Ala Val Cys Phe Gly Pro Val 
545                 550                 555                 560 


Leu Leu Pro Ala Arg Gln Ala Pro Thr Arg Pro Arg Ala Arg Ser Ser 
                565                 570                 575     


Gly Pro Gly Leu Ala Ser Ala Val Asp Phe Lys His His Ile Glu Val 
            580                 585                 590         


Leu His Tyr Leu Leu Gln Ser Trp Pro Asp Pro Arg Leu Pro Arg Gln 
        595                 600                 605             


Ser Pro Asp Val Ala Pro Tyr Leu Arg Pro Lys Arg Gln Pro Pro Leu 
    610                 615                 620                 


His Leu Pro Leu Ala Asp Pro Glu Val Val Thr Arg Pro Arg Gly Arg 
625                 630                 635                 640 


Gly Gly Pro Glu Ser Pro Pro Ser Asn Arg Tyr Ala Gly Asp Trp Ser 
                645                 650                 655     


Val Cys Gly Arg Asp Phe Leu Pro Cys Gly Arg Asp Phe Leu Ser Gly 
            660                 665                 670         


Pro Asp Tyr Asp His Val Thr Gly Ser Asp Ser Glu Asp Glu Asp Glu 
        675                 680                 685             


Glu Val Gly Glu Pro Arg Val Thr Gly Asp Phe Glu Asp Asp Phe Asp 
    690                 695                 700                 


Ala Pro Phe Asn Pro His Leu Asn Leu Lys Asp Phe Asp Ala Leu Ile 
705                 710                 715                 720 


Leu Asp Leu Glu Arg Glu Leu Ser Lys Gln Ile Asn Val Cys Leu 
                725                 730                 735 


<210> 5750
<211> 219
<212> PRT
<213> Homo sapiens

<400> 5750
Met Pro Arg Gly Arg Lys Ser Arg Arg Arg Arg Asn Ala Arg Ala Ala 
1               5                   10                  15      


Glu Glu Asn Arg Asn Asn Arg Lys Ile Gln Ala Ser Glu Ala Ser Glu 
            20                  25                  30          


Thr Pro Met Ala Ala Ser Val Val Ala Ser Thr Pro Glu Asp Asp Leu 
        35                  40                  45              


Ser Gly Pro Glu Glu Asp Pro Ser Thr Pro Glu Glu Ala Ser Thr Thr 
    50                  55                  60                  


Pro Glu Glu Ala Ser Ser Thr Ala Gln Ala Gln Lys Pro Ser Val Pro 
65                  70                  75                  80  


Arg Ser Asn Phe Gln Gly Thr Lys Lys Ser Leu Leu Met Ser Ile Leu 
                85                  90                  95      


Ala Leu Ile Phe Ile Met Gly Asn Ser Ala Lys Glu Ala Leu Val Trp 
            100                 105                 110         


Lys Val Leu Gly Lys Leu Gly Met Gln Pro Gly Arg Gln His Ser Ile 
        115                 120                 125             


Phe Gly Asp Pro Lys Lys Ile Val Thr Glu Glu Phe Val Arg Arg Gly 
    130                 135                 140                 


Tyr Leu Ile Tyr Lys Pro Val Pro Arg Ser Ser Pro Val Glu Tyr Glu 
145                 150                 155                 160 


Phe Phe Trp Gly Pro Arg Ala His Val Glu Ser Ser Lys Leu Lys Val 
                165                 170                 175     


Met His Phe Val Ala Arg Val Arg Asn Arg Cys Ser Lys Asp Trp Pro 
            180                 185                 190         


Cys Asn Tyr Asp Trp Asp Ser Asp Asp Asp Ala Glu Val Glu Ala Ile 
        195                 200                 205             


Leu Asn Ser Gly Ala Arg Gly Tyr Ser Ala Pro 
    210                 215                 


<210> 5751
<211> 233
<212> PRT
<213> Homo sapiens

<400> 5751
Met Asn Leu Asn Phe Thr Ser Pro Leu His Pro Ala Ser Ser Gln Arg 
1               5                   10                  15      


Pro Thr Ser Phe Phe Ile Glu Asp Ile Leu Leu His Lys Pro Lys Pro 
            20                  25                  30          


Leu Arg Glu Val Ala Pro Asp His Phe Ala Ser Ser Leu Ala Ser Arg 
        35                  40                  45              


Val Pro Leu Leu Asp Tyr Gly Tyr Pro Leu Met Pro Thr Pro Thr Leu 
    50                  55                  60                  


Leu Ala Pro His Ala His His Pro Leu His Lys Gly Asp His His His 
65                  70                  75                  80  


Pro Tyr Phe Leu Thr Thr Ser Gly Met Pro Val Pro Ala Leu Phe Pro 
                85                  90                  95      


His Pro Gln His Ala Glu Leu Pro Gly Lys His Cys Arg Arg Arg Lys 
            100                 105                 110         


Ala Arg Thr Val Phe Ser Asp Ser Gln Leu Ser Gly Leu Glu Lys Arg 
        115                 120                 125             


Phe Glu Ile Gln Arg Tyr Leu Ser Thr Pro Glu Arg Val Glu Leu Ala 
    130                 135                 140                 


Thr Ala Leu Ser Leu Ser Glu Thr Gln Val Lys Thr Trp Phe Gln Asn 
145                 150                 155                 160 


Arg Arg Met Lys His Lys Lys Gln Leu Arg Lys Ser Gln Asp Glu Pro 
                165                 170                 175     


Lys Ala Pro Asp Gly Pro Glu Ser Pro Glu Gly Ser Pro Arg Gly Ser 
            180                 185                 190         


Glu Ala Ala Thr Ala Ala Glu Ala Arg Leu Ser Leu Pro Ala Gly Pro 
        195                 200                 205             


Phe Val Leu Thr Glu Pro Glu Asp Glu Val Asp Ile Gly Asp Glu Gly 
    210                 215                 220                 


Glu Leu Gly Ser Gly Pro His Val Leu 
225                 230             


<210> 5752
<211> 290
<212> PRT
<213> Homo sapiens

<400> 5752
Met Glu Leu Pro Ala Val Gly Glu His Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Glu Lys Lys Arg Ile Arg Lys Gly Arg Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Arg Gly Trp Ser Pro Lys Tyr Asn Thr Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Arg Glu Arg Gln Glu 
    50                  55                  60                  


Gln Leu Met Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Pro Leu Val 
65                  70                  75                  80  


Val Gln Val Pro Thr Phe Ala Arg Arg Ser Asn Val Leu Thr Gly Leu 
                85                  90                  95      


Gln Asp Ser Ser Thr Asp Asn Arg Ala Lys Leu Asp Leu Gly Ala Gln 
            100                 105                 110         


Gly Lys Gly Gln Gly His Gln Tyr Glu Leu Asn Ser Lys Lys His His 
        115                 120                 125             


His His Ala Val Gly Leu Asn Leu Ser His Val Arg Lys Arg Cys Leu 
    130                 135                 140                 


Ser Glu Thr His Gly Glu Arg Glu Pro Cys Lys Lys Arg Leu Thr Ala 
145                 150                 155                 160 


Arg Ser Ile Ser Thr Pro Thr Cys Leu Gly Gly Ser Pro Ala Ala Glu 
                165                 170                 175     


Arg Pro Ala Asp Leu Pro Pro Ala Ala Ala Leu Pro Gln Pro Glu Val 
            180                 185                 190         


Ile Leu Leu Asp Ser Asp Leu Asp Glu Pro Ile Asp Leu Arg Cys Val 
        195                 200                 205             


Lys Thr Arg Ser Glu Ala Gly Glu Pro Pro Ser Ser Leu Gln Val Lys 
    210                 215                 220                 


Pro Glu Thr Pro Ala Ser Ala Ala Val Ala Val Ala Ala Ala Ala Ala 
225                 230                 235                 240 


Pro Thr Thr Thr Ala Glu Lys Pro Pro Ala Glu Ala Gln Asp Glu Pro 
                245                 250                 255     


Ala Glu Ser Leu Ser Glu Phe Lys Pro Phe Phe Gly Asn Ile Ile Ile 
            260                 265                 270         


Thr Asp Val Thr Ala Asn Cys Leu Thr Val Thr Phe Lys Glu Tyr Val 
        275                 280                 285             


Thr Val 
    290 


<210> 5753
<211> 247
<212> PRT
<213> Homo sapiens

<400> 5753
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Pro 
        115                 120                 125             


Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr 
    130                 135                 140                 


His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp 
145                 150                 155                 160 


Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg 
                165                 170                 175     


Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val 
            180                 185                 190         


Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn 
        195                 200                 205             


Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser 
    210                 215                 220                 


Ser Asp Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys 
225                 230                 235                 240 


Gly Thr Pro Val His Ser Ser 
                245         


<210> 5754
<211> 181
<212> PRT
<213> Homo sapiens

<400> 5754
Met Val Ser Ser Cys Cys Gly Ser Val Ser Ser Glu Gln Ser Cys Gly 
1               5                   10                  15      


Leu Glu Asn Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg 
            20                  25                  30          


Thr Thr Cys Cys Arg Pro Ser Cys Cys Lys Pro Gln Cys Cys Gln Ser 
        35                  40                  45              


Val Cys Tyr Gln Pro Thr Cys Cys His Pro Ser Cys Cys Ile Ser Ser 
    50                  55                  60                  


Cys Cys Arg Pro Tyr Cys Cys Glu Ser Ser Cys Cys Arg Pro Cys Cys 
65                  70                  75                  80  


Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys Arg Thr Thr Cys Cys 
                85                  90                  95      


Cys Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln 
            100                 105                 110         


Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Ile Ser 
        115                 120                 125             


Ser Cys Cys His Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg Pro Cys 
    130                 135                 140                 


Cys Cys Val Arg Pro Val Cys Gly Arg Val Ser Cys His Thr Thr Cys 
145                 150                 155                 160 


Tyr Arg Pro Thr Cys Val Ile Ser Thr Cys Pro Arg Pro Leu Cys Cys 
                165                 170                 175     


Ala Ser Ser Cys Cys 
            180     


<210> 5755
<211> 361
<212> PRT
<213> Homo sapiens

<400> 5755
Met Ala Leu Asn Val Ala Pro Val Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Gln Phe Gln Arg Gly Thr Cys Ser Arg Ser Asp Glu 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Pro Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Thr His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Thr Ala Ala Ala Met 
                85                  90                  95      


Leu Ala Gln Gln Met Gln Phe Met Phe Pro Gly Thr Pro Leu His Pro 
            100                 105                 110         


Val Pro Thr Phe Pro Val Gly Pro Ala Ile Gly Thr Asn Thr Ala Ile 
        115                 120                 125             


Ser Phe Ala Pro Tyr Leu Ala Pro Val Thr Pro Gly Val Gly Leu Val 
    130                 135                 140                 


Pro Thr Glu Ile Leu Pro Thr Thr Pro Val Ile Val Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Val Thr Val Pro Gly Ser Thr Ala Thr Gln Lys Leu Leu Arg Thr 
                165                 170                 175     


Asp Lys Leu Glu Val Cys Arg Glu Phe Gln Arg Gly Asn Cys Ala Arg 
            180                 185                 190         


Gly Glu Thr Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile 
        195                 200                 205             


Asp Thr Ser Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly 
    210                 215                 220                 


Arg Cys Met Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu 
225                 230                 235                 240 


Gln Ala Lys Ile Lys Ala Ala Gln His Gln Ala Asn Gln Ala Ala Val 
                245                 250                 255     


Ala Ala Gln Ala Ala Ala Ala Ala Ala Thr Val Met Ala Phe Pro Pro 
            260                 265                 270         


Gly Ala Leu His Pro Leu Pro Lys Arg Gln Ala Leu Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ser Ala Val Phe Asn Pro Ser Val Leu His Tyr Gln Gln Ala 
    290                 295                 300                 


Leu Thr Ser Ala Gln Leu Gln Gln His Ala Ala Phe Ile Pro Thr Asp 
305                 310                 315                 320 


Asn Ser Glu Ile Ile Ser Arg Asn Gly Met Glu Cys Gln Glu Ser Ala 
                325                 330                 335     


Leu Arg Ile Thr Lys His Cys Tyr Cys Thr Tyr Tyr Pro Val Ser Ser 
            340                 345                 350         


Ser Ile Glu Leu Pro Gln Thr Ala Cys 
        355                 360     


<210> 5756
<211> 338
<212> PRT
<213> Homo sapiens

<400> 5756
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Phe Ser Ile Arg 
    130                 135                 140                 


Gly Lys Asn Gln Tyr Gln Thr Arg Val Ile His Asp Gly Ala Arg Leu 
145                 150                 155                 160 


Phe Arg Ile Lys Cys Val Thr Arg Ile Gln Ala Tyr Trp Arg Gly Cys 
                165                 170                 175     


Val Val Arg Lys Trp Tyr Arg Asn Leu Arg Lys Thr Val Pro Pro Thr 
            180                 185                 190         


Asp Ala Lys Leu Arg Lys Lys Phe Phe Glu Lys Lys Phe Thr Glu Ile 
        195                 200                 205             


Ser His Arg Ile Leu Cys Ser Tyr Asn Thr Asn Ile Glu Glu Leu Phe 
    210                 215                 220                 


Ala Glu Ile Asp Gln Cys Leu Ala Ile Asn Arg Ser Val Leu Gln Gln 
225                 230                 235                 240 


Leu Glu Glu Lys Cys Gly His Glu Ile Thr Glu Glu Glu Trp Glu Lys 
                245                 250                 255     


Ile Gln Val Gln Ala Leu Arg Arg Glu Thr His Glu Cys Ser Ile Cys 
            260                 265                 270         


Leu Ala Pro Leu Ser Ala Ala Gly Gly Gln Arg Val Gly Ala Gly Arg 
        275                 280                 285             


Arg Ser Arg Glu Met Ala Leu Leu Ser Cys Ser His Val Phe His His 
    290                 295                 300                 


Ala Cys Leu Leu Ala Leu Glu Glu Phe Ser Val Gly Asp Arg Pro Pro 
305                 310                 315                 320 


Phe His Ala Cys Pro Leu Cys Arg Ser Cys Tyr Gln Lys Lys Ile Leu 
                325                 330                 335     


Glu Cys 
        


<210> 5757
<211> 365
<212> PRT
<213> Homo sapiens

<400> 5757
Met Ala Ala Ala Ala Ala Gly Thr Ala Thr Ser Gln Arg Phe Phe Gln 
1               5                   10                  15      


Ser Phe Ser Asp Ala Leu Ile Asp Glu Asp Pro Gln Ala Ala Leu Glu 
            20                  25                  30          


Glu Leu Thr Lys Ala Leu Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr 
        35                  40                  45              


Cys Gln Arg Ala Tyr Cys His Ile Leu Leu Gly Asn Tyr Cys Val Ala 
    50                  55                  60                  


Val Ala Asp Ala Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr 
65                  70                  75                  80  


Ala Met Leu Arg Lys Gly Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala 
                85                  90                  95      


Ala Ala Leu Glu Thr Phe Thr Glu Gly Gln Lys Leu Asp Ile Glu Thr 
            100                 105                 110         


Gly Phe His Arg Val Gly Gln Ala Gly Leu Gln Leu Leu Thr Ser Ser 
        115                 120                 125             


Asp Pro Pro Ala Leu Asp Ser Gln Ser Ala Gly Ile Thr Gly Ala Asp 
    130                 135                 140                 


Ala Asn Phe Ser Val Trp Ile Lys Arg Cys Gln Glu Ala Gln Asn Gly 
145                 150                 155                 160 


Ser Glu Ser Glu Val Trp Thr His Gln Ser Lys Ile Lys Tyr Asp Trp 
                165                 170                 175     


Tyr Gln Thr Glu Ser Gln Val Val Ile Thr Leu Met Ile Lys Asn Val 
            180                 185                 190         


Gln Lys Asn Asp Val Asn Val Glu Phe Ser Glu Lys Glu Leu Ser Ala 
        195                 200                 205             


Leu Val Lys Leu Pro Ser Gly Glu Asp Tyr Asn Leu Lys Leu Glu Leu 
    210                 215                 220                 


Leu His Pro Ile Ile Pro Glu Gln Ser Thr Phe Lys Val Leu Ser Thr 
225                 230                 235                 240 


Lys Ile Glu Ile Lys Leu Lys Lys Pro Glu Ala Val Arg Trp Glu Lys 
                245                 250                 255     


Leu Glu Gly Gln Gly Asp Val Pro Thr Pro Lys Gln Phe Val Ala Asp 
            260                 265                 270         


Val Lys Asn Leu Tyr Pro Ser Ser Ser Pro Tyr Thr Arg Asn Trp Asp 
        275                 280                 285             


Lys Leu Val Gly Glu Ile Lys Glu Glu Glu Lys Asn Glu Lys Leu Glu 
    290                 295                 300                 


Gly Asp Ala Ala Leu Asn Arg Leu Phe Gln Gln Ile Tyr Ser Asp Gly 
305                 310                 315                 320 


Ser Asp Glu Val Lys Arg Ala Met Asn Lys Ser Phe Met Glu Ser Gly 
                325                 330                 335     


Gly Thr Val Leu Ser Thr Asn Trp Ser Asp Val Gly Lys Arg Lys Val 
            340                 345                 350         


Glu Ile Asn Pro Pro Asp Asp Met Glu Trp Lys Lys Tyr 
        355                 360                 365 


<210> 5758
<211> 462
<212> PRT
<213> Homo sapiens

<400> 5758
Met Asp Lys Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser 
1               5                   10                  15      


Gly Thr Ala Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys 
            20                  25                  30          


Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser 
        35                  40                  45              


Ser Arg Phe Ile Lys Arg Lys Lys Phe Asp Asp Glu Leu Val Glu Ser 
    50                  55                  60                  


Ser Leu Ala Lys Ser Ser Thr Arg Ala Lys Gly Ala Ser Gly Val Glu 
65                  70                  75                  80  


Pro Gly Arg Cys Ser Gly Ser Glu Pro Ser Ser Ser Glu Lys Lys Lys 
                85                  90                  95      


Val Ser Lys Ala Pro Ser Thr Pro Val Pro Pro Ser Pro Ala Pro Ala 
            100                 105                 110         


Pro Gly Leu Thr Lys Arg Val Lys Lys Ser Lys Gln Pro Leu Gln Val 
        115                 120                 125             


Thr Lys Asp Leu Gly Arg Trp Lys Pro Ala Asp Asp Leu Leu Leu Ile 
    130                 135                 140                 


Asn Ala Val Leu Gln Thr Asn Asp Leu Thr Ser Val His Leu Gly Val 
145                 150                 155                 160 


Lys Phe Ser Cys Arg Phe Thr Leu Arg Glu Val Gln Glu Arg Trp Tyr 
                165                 170                 175     


Ala Leu Leu Tyr Asp Pro Val Ile Ser Lys Leu Ala Cys Gln Ala Met 
            180                 185                 190         


Arg Gln Leu His Pro Glu Ala Ile Ala Ala Ile Gln Ser Lys Ala Leu 
        195                 200                 205             


Phe Ser Lys Ala Glu Glu Gln Leu Leu Ser Lys Val Gly Ser Thr Ser 
    210                 215                 220                 


Gln Pro Thr Leu Glu Thr Phe Gln Asp Leu Leu His Arg His Pro Asp 
225                 230                 235                 240 


Ala Phe Tyr Leu Ala Arg Thr Ala Lys Ala Leu Gln Ala His Trp Gln 
                245                 250                 255     


Leu Met Lys Gln Tyr Tyr Leu Leu Glu Asp Gln Thr Val Gln Pro Leu 
            260                 265                 270         


Pro Lys Gly Asp Gln Val Leu Asn Phe Ser Asp Ala Glu Asp Leu Ile 
        275                 280                 285             


Asp Asp Ser Lys Leu Lys Asp Met Arg Asp Glu Val Leu Glu His Glu 
    290                 295                 300                 


Leu Met Val Ala Asp Arg Arg Gln Lys Arg Glu Ile Arg Gln Leu Glu 
305                 310                 315                 320 


Gln Glu Leu His Lys Trp Gln Val Leu Val Asp Ser Ile Thr Gly Met 
                325                 330                 335     


Ser Ser Pro Asp Phe Asp Asn Gln Thr Leu Ala Val Leu Arg Gly Arg 
            340                 345                 350         


Met Val Arg Tyr Leu Met Arg Ser Arg Glu Ile Thr Leu Gly Arg Ala 
        355                 360                 365             


Thr Lys Asp Asn Gln Ile Asp Val Asp Leu Ser Leu Glu Gly Pro Ala 
    370                 375                 380                 


Trp Lys Ile Ser Arg Lys Gln Gly Val Ile Lys Leu Lys Asn Asn Gly 
385                 390                 395                 400 


Asp Phe Phe Ile Ala Asn Glu Gly Arg Arg Pro Ile Tyr Ile Asp Gly 
                405                 410                 415     


Arg Pro Val Leu Cys Gly Ser Lys Trp Arg Leu Ser Asn Asn Ser Val 
            420                 425                 430         


Val Glu Ile Ala Ser Leu Arg Phe Val Phe Leu Ile Asn Gln Asp Leu 
        435                 440                 445             


Ile Ala Leu Ile Arg Ala Glu Ala Ala Lys Ile Thr Pro Gln 
    450                 455                 460         


<210> 5759
<211> 320
<212> PRT
<213> Homo sapiens

<400> 5759
Met Ser Val Gly Phe Ile Gly Ala Gly Gln Leu Ala Tyr Ala Leu Ala 
1               5                   10                  15      


Arg Gly Phe Thr Ala Ala Gly Ile Leu Ser Ala His Lys Ile Ile Ala 
            20                  25                  30          


Ser Ser Pro Glu Met Asn Leu Pro Thr Val Ser Ala Leu Arg Lys Met 
        35                  40                  45              


Gly Val Asn Leu Thr Arg Ser Asn Lys Glu Thr Val Lys His Ser Asp 
    50                  55                  60                  


Val Leu Phe Leu Ala Val Lys Pro His Ile Ile Pro Phe Ile Leu Asp 
65                  70                  75                  80  


Glu Ile Gly Ala Asp Val Gln Ala Arg His Ile Val Val Ser Cys Ala 
                85                  90                  95      


Ala Gly Val Thr Ile Ser Ser Val Glu Lys Lys Leu Met Ala Phe Gln 
            100                 105                 110         


Pro Ala Pro Lys Val Ile Arg Cys Met Thr Asn Thr Pro Val Val Val 
        115                 120                 125             


Gln Glu Gly Ala Thr Val Tyr Ala Thr Gly Thr His Ala Leu Val Glu 
    130                 135                 140                 


Asp Gly Gln Leu Leu Glu Gln Leu Met Ser Ser Val Gly Phe Cys Thr 
145                 150                 155                 160 


Glu Val Glu Glu Asp Leu Ile Asp Ala Val Thr Gly Leu Ser Gly Ser 
                165                 170                 175     


Gly Pro Ala Tyr Ala Phe Met Ala Leu Asp Ala Leu Ala Asp Gly Gly 
            180                 185                 190         


Val Lys Met Gly Leu Pro Arg Arg Leu Ala Ile Gln Leu Gly Ala Gln 
        195                 200                 205             


Ala Leu Leu Gly Ala Ala Lys Met Leu Leu Asp Ser Glu Gln His Pro 
    210                 215                 220                 


Cys Gln Leu Lys Asp Asn Val Cys Ser Pro Gly Gly Ala Thr Ile His 
225                 230                 235                 240 


Ala Leu His Phe Leu Glu Ser Gly Gly Phe Arg Ser Leu Leu Ile Asn 
                245                 250                 255     


Ala Val Glu Ala Ser Cys Ile Arg Thr Arg Glu Leu Gln Ser Met Ala 
            260                 265                 270         


Asp Gln Glu Lys Ile Ser Pro Ala Ala Leu Lys Lys Thr Leu Leu Asp 
        275                 280                 285             


Arg Val Lys Leu Glu Ser Pro Thr Val Ser Thr Leu Thr Pro Ser Ser 
    290                 295                 300                 


Pro Gly Lys Leu Leu Thr Arg Ser Leu Ala Leu Gly Gly Lys Lys Asp 
305                 310                 315                 320 


<210> 5760
<211> 789
<212> PRT
<213> Homo sapiens

<400> 5760
Met Glu Asp Gly Pro Ser Asn Asn Ala Ser Cys Phe Arg Arg Leu Thr 
1               5                   10                  15      


Glu Cys Phe Leu Ser Pro Ser Leu Thr Asp Glu Lys Val Lys Ala Tyr 
            20                  25                  30          


Leu Ser Leu His Pro Gln Val Leu Asp Glu Phe Val Ser Glu Ser Val 
        35                  40                  45              


Ser Ala Glu Thr Val Glu Lys Trp Leu Lys Arg Lys Asn Asn Lys Ser 
    50                  55                  60                  


Glu Asp Glu Ser Ala Pro Lys Glu Val Ser Arg Tyr Gln Asp Thr Asn 
65                  70                  75                  80  


Met Gln Gly Val Val Tyr Glu Leu Asn Ser Tyr Ile Glu Gln Arg Leu 
                85                  90                  95      


Asp Thr Gly Gly Asp Asn Gln Leu Leu Leu Tyr Glu Leu Ser Ser Ile 
            100                 105                 110         


Ile Lys Ile Ala Thr Lys Ala Asp Gly Phe Ala Leu Tyr Phe Leu Gly 
        115                 120                 125             


Glu Cys Asn Asn Ser Leu Cys Ile Phe Thr Pro Pro Gly Ile Lys Glu 
    130                 135                 140                 


Gly Lys Pro Arg Leu Ile Pro Ala Gly Pro Ile Thr Gln Gly Thr Thr 
145                 150                 155                 160 


Val Ser Ala Tyr Val Ala Lys Ser Arg Lys Thr Leu Leu Val Glu Asp 
                165                 170                 175     


Ile Leu Gly Asp Glu Arg Phe Pro Arg Gly Thr Gly Leu Glu Ser Gly 
            180                 185                 190         


Thr Arg Ile Gln Ser Val Leu Cys Leu Pro Ile Val Thr Ala Ile Gly 
        195                 200                 205             


Asp Leu Ile Gly Ile Leu Glu Leu Tyr Arg His Trp Gly Lys Glu Ala 
    210                 215                 220                 


Phe Cys Leu Ser His Gln Glu Val Ala Thr Ala Asn Leu Ala Trp Ala 
225                 230                 235                 240 


Ser Val Ala Ile His Gln Val Gln Val Cys Arg Gly Leu Ala Lys Gln 
                245                 250                 255     


Thr Glu Leu Asn Asp Phe Leu Leu Asp Val Ser Lys Thr Tyr Phe Asp 
            260                 265                 270         


Asn Ile Val Ala Ile Asp Ser Leu Leu Glu His Ile Met Ile Tyr Ala 
        275                 280                 285             


Lys Asn Leu Val Asn Ala Asp Arg Cys Ala Leu Phe Gln Val Asp His 
    290                 295                 300                 


Lys Asn Lys Glu Leu Tyr Ser Asp Leu Phe Asp Ile Gly Glu Glu Lys 
305                 310                 315                 320 


Glu Gly Lys Pro Val Phe Lys Lys Thr Lys Glu Ile Arg Phe Ser Ile 
                325                 330                 335     


Glu Lys Gly Ile Ala Gly Gln Val Ala Arg Thr Gly Glu Val Leu Asn 
            340                 345                 350         


Ile Pro Asp Ala Tyr Ala Asp Pro Arg Phe Asn Arg Glu Val Asp Leu 
        355                 360                 365             


Tyr Thr Gly Tyr Thr Thr Arg Asn Ile Leu Cys Met Pro Ile Val Ser 
    370                 375                 380                 


Arg Gly Ser Val Ile Gly Val Val Gln Met Val Asn Lys Ile Ser Gly 
385                 390                 395                 400 


Ser Ala Phe Ser Lys Thr Asp Glu Asn Asn Phe Lys Met Phe Ala Val 
                405                 410                 415     


Phe Cys Ala Leu Ala Leu His Cys Ala Asn Met Tyr His Arg Ile Arg 
            420                 425                 430         


His Ser Glu Cys Ile Tyr Arg Val Thr Met Glu Lys Leu Ser Tyr His 
        435                 440                 445             


Ser Ile Cys Thr Ser Glu Glu Trp Gln Gly Leu Met Gln Phe Thr Leu 
    450                 455                 460                 


Pro Val Arg Leu Cys Lys Glu Ile Glu Leu Phe His Phe Asp Ile Gly 
465                 470                 475                 480 


Pro Phe Glu Asn Met Trp Pro Gly Ile Phe Val Tyr Met Val His Arg 
                485                 490                 495     


Ser Cys Gly Thr Ser Cys Phe Glu Leu Glu Lys Leu Cys Arg Phe Ile 
            500                 505                 510         


Met Ser Val Lys Lys Asn Tyr Arg Arg Val Pro Tyr His Asn Trp Lys 
        515                 520                 525             


His Ala Val Thr Val Ala His Cys Met Tyr Ala Ile Leu Gln Asn Asn 
    530                 535                 540                 


His Thr Leu Phe Thr Asp Leu Glu Arg Lys Gly Leu Leu Ile Ala Cys 
545                 550                 555                 560 


Leu Cys His Asp Leu Asp His Arg Gly Phe Ser Asn Ser Tyr Leu Gln 
                565                 570                 575     


Lys Phe Asp His Pro Leu Ala Ala Leu Tyr Ser Thr Ser Thr Met Glu 
            580                 585                 590         


Gln His His Phe Ser Gln Thr Val Ser Ile Leu Gln Leu Glu Gly His 
        595                 600                 605             


Asn Ile Phe Ser Thr Leu Ser Ser Ser Glu Tyr Glu Gln Val Leu Glu 
    610                 615                 620                 


Ile Ile Arg Lys Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr Phe Gly 
625                 630                 635                 640 


Asn Arg Lys Gln Leu Glu Glu Met Tyr Gln Thr Gly Ser Leu Asn Leu 
                645                 650                 655     


Asn Asn Gln Ser His Arg Asp Arg Val Ile Gly Leu Met Met Thr Ala 
            660                 665                 670         


Cys Asp Leu Cys Ser Val Thr Lys Leu Trp Pro Val Thr Lys Leu Thr 
        675                 680                 685             


Ala Asn Asp Ile Tyr Ala Glu Phe Trp Ala Glu Gly Asp Glu Met Lys 
    690                 695                 700                 


Lys Leu Gly Ile Gln Pro Ile Pro Met Met Asp Arg Asp Lys Lys Asp 
705                 710                 715                 720 


Glu Val Pro Gln Gly Gln Leu Gly Phe Tyr Asn Ala Val Ala Ile Pro 
                725                 730                 735     


Cys Tyr Thr Thr Leu Thr Gln Ile Leu Pro Pro Thr Glu Pro Leu Leu 
            740                 745                 750         


Lys Ala Cys Arg Asp Asn Leu Ser Gln Trp Glu Lys Val Ile Arg Gly 
        755                 760                 765             


Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro Ser Val Ala Gln Lys Ala 
    770                 775                 780                 


Ala Ala Ser Glu Asp 
785                 


<210> 5761
<211> 214
<212> PRT
<213> Homo sapiens

<400> 5761
Met Asp Asp Ser Glu Thr Gly Phe Asn Leu Lys Val Val Leu Val Ser 
1               5                   10                  15      


Phe Lys Gln Cys Leu Asp Glu Lys Glu Glu Val Leu Leu Asp Pro Tyr 
            20                  25                  30          


Ile Ala Ser Trp Lys Gly Leu Val Arg Phe Leu Asn Ser Leu Gly Thr 
        35                  40                  45              


Ile Phe Ser Phe Ile Ser Lys Asp Val Val Ser Lys Leu Arg Ile Met 
    50                  55                  60                  


Glu Arg Leu Arg Gly Gly Pro Gln Ser Glu His Tyr Arg Ser Leu Gln 
65                  70                  75                  80  


Ala Met Val Ala His Glu Leu Ser Asn Arg Leu Val Asp Leu Glu Arg 
                85                  90                  95      


Arg Ser His His Pro Glu Ser Gly Cys Arg Thr Val Leu Arg Leu His 
            100                 105                 110         


Arg Ala Leu His Trp Leu Gln Leu Phe Leu Glu Gly Leu Arg Thr Ser 
        115                 120                 125             


Pro Glu Asp Ala Arg Thr Ser Ala Leu Cys Ala Asp Ser Tyr Asn Ala 
    130                 135                 140                 


Ser Leu Ala Ala Tyr His Pro Trp Val Val Arg Arg Ala Val Thr Val 
145                 150                 155                 160 


Ala Phe Cys Thr Leu Pro Thr Arg Glu Val Phe Leu Glu Ala Met Asn 
                165                 170                 175     


Val Gly Pro Pro Glu Gln Ala Val Gln Met Leu Gly Glu Ala Leu Pro 
            180                 185                 190         


Phe Ile Gln Arg Val Tyr Asn Val Ser Gln Lys Leu Tyr Ala Glu His 
        195                 200                 205             


Ser Leu Leu Asp Leu Pro 
    210                 


<210> 5762
<211> 1430
<212> PRT
<213> Homo sapiens

<400> 5762
Met Thr Ser Ala Ala Glu Ile Lys Lys Pro Pro Val Ala Pro Lys Pro 
1               5                   10                  15      


Lys Phe Val Val Ala Asn Asn Lys Pro Ala Pro Pro Pro Ile Ala Pro 
            20                  25                  30          


Lys Pro Asp Ile Val Ile Ser Ser Val Pro Gln Ser Thr Lys Lys Met 
        35                  40                  45              


Lys Pro Ala Ile Ala Pro Lys Pro Lys Val Leu Lys Thr Ser Pro Val 
    50                  55                  60                  


Arg Glu Ile Gly Gln Ser Pro Ser Arg Lys Ile Met Leu Asn Leu Glu 
65                  70                  75                  80  


Gly His Lys Gln Glu Leu Ala Glu Ser Thr Asp Asn Phe Asn Cys Lys 
                85                  90                  95      


Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser Cys 
            100                 105                 110         


Ser Ser Glu Cys Ile His Lys Leu Gly His Arg Glu Asn Leu Cys Val 
        115                 120                 125             


Lys Gln Leu Val Leu Glu Pro Leu Glu Met Asn Glu Asn Leu Glu Asn 
    130                 135                 140                 


Ser Lys Ile Asp Glu Thr Leu Thr Ile Lys Thr Arg Ser Lys Cys Asp 
145                 150                 155                 160 


Leu Tyr Gly Glu Lys Ala Lys Asn Gln Gly Gly Val Val Leu Lys Ala 
                165                 170                 175     


Ser Val Leu Glu Glu Glu Leu Lys Asp Ala Leu Ile His Gln Met Pro 
            180                 185                 190         


Pro Phe Ile Ser Ala Gln Lys His Arg Pro Thr Asp Ser Pro Glu Met 
        195                 200                 205             


Asn Gly Gly Cys Asn Ser Asn Gly Gln Phe Arg Ile Glu Phe Ala Asp 
    210                 215                 220                 


Leu Ser Pro Ser Pro Ser Ser Phe Glu Lys Val Pro Asp His His Ser 
225                 230                 235                 240 


Cys His Leu Gln Leu Pro Ser Asp Glu Cys Glu His Phe Glu Thr Cys 
                245                 250                 255     


Gln Asp Asp Ser Glu Lys Ser Asn Asn Cys Phe Gln Ser Ser Glu Leu 
            260                 265                 270         


Glu Ala Leu Glu Asn Gly Lys Arg Ser Thr Leu Ile Ser Ser Asp Gly 
        275                 280                 285             


Val Ser Lys Lys Ser Glu Val Lys Asp Leu Gly Pro Leu Glu Ile His 
    290                 295                 300                 


Leu Val Pro Tyr Thr Pro Lys Phe Pro Thr Pro Lys Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Ala Arg Leu Leu Arg Gln Lys Cys Val Asp Thr Pro Ser Glu 
                325                 330                 335     


Ser Thr Glu Glu Pro Gly Asn Ser Asp Ser Ser Ser Ser Cys Leu Thr 
            340                 345                 350         


Glu Asn Ser Leu Lys Ile Asn Lys Ile Ser Val Leu His Gln Asn Val 
        355                 360                 365             


Leu Cys Lys Gln Glu Gln Val Asp Lys Met Lys Leu Gly Asn Lys Ser 
    370                 375                 380                 


Glu Leu Asn Met Glu Ser Asn Ser Asp Ala Gln Asp Leu Val Asn Ser 
385                 390                 395                 400 


Gln Lys Ala Met Cys Asn Glu Thr Thr Ser Phe Glu Lys Met Ala Pro 
                405                 410                 415     


Ser Phe Asp Lys Asp Ser Asn Leu Ser Ser Asp Ser Thr Thr Val Asp 
            420                 425                 430         


Gly Ser Ser Met Ser Leu Ala Val Asp Glu Gly Thr Gly Phe Ile Arg 
        435                 440                 445             


Cys Thr Val Ser Met Ser Leu Pro Lys Gln Leu Lys Leu Thr Cys Asn 
    450                 455                 460                 


Glu His Leu Gln Ser Gly Arg Asn Leu Gly Val Ser Ala Pro Gln Met 
465                 470                 475                 480 


Gln Lys Glu Ser Val Ile Lys Glu Glu Asn Ser Leu Arg Ile Val Pro 
                485                 490                 495     


Lys Lys Pro Gln Arg His Ser Leu Pro Ala Thr Gly Val Leu Lys Lys 
            500                 505                 510         


Ala Ala Ser Glu Glu Leu Leu Glu Lys Ser Ser Tyr Pro Ser Ser Glu 
        515                 520                 525             


Glu Lys Ser Ser Glu Lys Ser Leu Glu Arg Asn His Leu Gln His Leu 
    530                 535                 540                 


Cys Ala Gln Asn Arg Gly Val Ser Ser Ser Phe Asp Met Pro Lys Arg 
545                 550                 555                 560 


Ala Ser Glu Lys Pro Val Trp Lys Leu Pro His Pro Ile Leu Pro Phe 
                565                 570                 575     


Ser Gly Asn Pro Glu Phe Leu Lys Ser Val Thr Val Ser Ser Asn Ser 
            580                 585                 590         


Glu Pro Ser Thr Ala Leu Thr Lys Pro Arg Ala Lys Ser Leu Ser Ala 
        595                 600                 605             


Met Asp Val Glu Lys Cys Thr Lys Pro Cys Lys Asp Ser Thr Lys Lys 
    610                 615                 620                 


Asn Ser Phe Lys Lys Leu Leu Ser Met Lys Leu Ser Ile Cys Phe Met 
625                 630                 635                 640 


Lys Ser Asp Phe Gln Lys Phe Trp Ser Lys Ser Ser Gln Leu Gly Asp 
                645                 650                 655     


Thr Thr Thr Gly His Leu Ser Ser Gly Glu Gln Lys Gly Ile Glu Ser 
            660                 665                 670         


Asp Trp Gln Gly Leu Leu Val Gly Glu Glu Lys Arg Ser Lys Pro Ile 
        675                 680                 685             


Lys Ala Tyr Ser Thr Glu Asn Tyr Ser Leu Glu Ser Gln Lys Lys Arg 
    690                 695                 700                 


Lys Lys Ser Arg Gly Gln Thr Ser Ala Ala Asn Gly Leu Arg Ala Glu 
705                 710                 715                 720 


Ser Leu Asp Asp Gln Met Leu Ser Arg Glu Ser Ser Ser Gln Ala Pro 
                725                 730                 735     


Tyr Lys Ser Val Thr Ser Leu Cys Ala Pro Glu Tyr Glu Asn Ile Arg 
            740                 745                 750         


His Tyr Glu Glu Ile Pro Glu Tyr Glu Asn Leu Pro Phe Ile Met Ala 
        755                 760                 765             


Ile Arg Lys Thr Gln Glu Leu Glu Trp Gln Asn Ser Ser Ser Met Glu 
    770                 775                 780                 


Asp Ala Asp Ala Asn Val Tyr Glu Val Glu Glu Pro Tyr Glu Ala Pro 
785                 790                 795                 800 


Asp Gly Gln Leu Gln Leu Gly Pro Arg His Gln His Ser Ser Ser Gly 
                805                 810                 815     


Ala Ser Gln Glu Glu Gln Asn Asp Leu Gly Leu Gly Asp Leu Pro Ser 
            820                 825                 830         


Asp Glu Glu Glu Ile Ile Asn Ser Ser Asp Glu Asp Asp Val Ser Ser 
        835                 840                 845             


Glu Ser Ser Lys Gly Glu Pro Asp Pro Leu Glu Asp Lys Gln Asp Glu 
    850                 855                 860                 


Asp Asn Gly Met Lys Ser Lys Val His His Ile Ala Lys Glu Ile Met 
865                 870                 875                 880 


Ser Ser Glu Lys Val Phe Val Asp Val Leu Lys Leu Leu His Ile Asp 
                885                 890                 895     


Phe Arg Asp Ala Val Ala His Ala Ser Arg Gln Leu Gly Lys Pro Val 
            900                 905                 910         


Ile Glu Asp Arg Ile Leu Asn Gln Ile Leu Tyr Tyr Leu Pro Gln Leu 
        915                 920                 925             


Tyr Glu Leu Asn Arg Asp Leu Leu Lys Glu Leu Glu Glu Arg Met Leu 
    930                 935                 940                 


His Trp Thr Glu Gln Gln Arg Ile Ala Asp Ile Phe Val Lys Lys Gly 
945                 950                 955                 960 


Pro Tyr Leu Lys Met Tyr Ser Thr Tyr Ile Lys Glu Phe Asp Lys Asn 
                965                 970                 975     


Ile Ala Leu Leu Asp Glu Gln Cys Lys Lys Asn Pro Gly Phe Ala Ala 
            980                 985                 990         


Val Val Arg Glu Phe Glu Met Ser  Pro Arg Cys Ala Asn  Leu Ala Leu 
        995                 1000                 1005             


Lys His  Tyr Leu Leu Lys Pro  Val Gln Arg Ile Pro  Gln Tyr Arg 
    1010                 1015                 1020             


Leu Leu  Leu Thr Asp Tyr Leu  Lys Asn Leu Ile Glu  Asp Ala Gly 
    1025                 1030                 1035             


Asp Tyr  Arg Asp Thr Gln Asp  Ala Leu Ala Val Val  Ile Glu Val 
    1040                 1045                 1050             


Ala Asn  His Ala Asn Asp Thr  Met Lys Gln Gly Asp  Asn Phe Gln 
    1055                 1060                 1065             


Lys Leu  Met Gln Ile Gln Tyr  Ser Leu Asn Gly His  His Glu Ile 
    1070                 1075                 1080             


Val Gln  Pro Gly Arg Val Phe  Leu Lys Glu Gly Ile  Leu Met Lys 
    1085                 1090                 1095             


Leu Ser  Arg Lys Val Met Gln  Pro Arg Met Phe Phe  Leu Phe Asn 
    1100                 1105                 1110             


Asp Ala  Leu Leu Tyr Thr Thr  Pro Val Gln Ser Gly  Met Tyr Lys 
    1115                 1120                 1125             


Leu Asn  Asn Met Leu Ser Leu  Ala Gly Met Lys Val  Arg Lys Pro 
    1130                 1135                 1140             


Thr Gln  Glu Ala Tyr Gln Asn  Glu Leu Lys Ile Glu  Ser Val Glu 
    1145                 1150                 1155             


Arg Ser  Phe Ile Leu Ser Ala  Ser Ser Ala Thr Glu  Arg Asp Glu 
    1160                 1165                 1170             


Trp Leu  Glu Ala Ile Ser Arg  Ala Ile Glu Glu Tyr  Ala Lys Lys 
    1175                 1180                 1185             


Arg Ile  Thr Phe Cys Pro Ser  Arg Ser Leu Asp Glu  Ala Asp Ser 
    1190                 1195                 1200             


Glu Asn  Lys Glu Glu Val Ser  Pro Leu Gly Ser Lys  Ala Pro Ile 
    1205                 1210                 1215             


Trp Ile  Pro Asp Thr Arg Ala  Thr Met Cys Met Ile  Cys Thr Ser 
    1220                 1225                 1230             


Glu Phe  Thr Leu Thr Trp Arg  Arg His His Cys Arg  Ala Cys Gly 
    1235                 1240                 1245             


Lys Ile  Val Cys Gln Ala Cys  Ser Ser Asn Lys Tyr  Gly Leu Asp 
    1250                 1255                 1260             


Tyr Leu  Lys Asn Gln Pro Ala  Arg Val Cys Glu His  Cys Phe Gln 
    1265                 1270                 1275             


Glu Leu  Gln Lys Leu Asp His  Gln His Ser Pro Arg  Ile Gly Ser 
    1280                 1285                 1290             


Pro Gly  Asn His Lys Ser Pro  Ser Ser Ala Leu Ser  Ser Val Leu 
    1295                 1300                 1305             


His Ser  Ile Pro Ser Gly Arg  Lys Gln Lys Lys Ile  Pro Ala Ala 
    1310                 1315                 1320             


Leu Lys  Glu Val Ser Ala Asn  Thr Glu Asp Ser Ser  Met Ser Gly 
    1325                 1330                 1335             


Tyr Leu  Tyr Arg Ser Lys Gly  Asn Lys Lys Pro Trp  Lys His Phe 
    1340                 1345                 1350             


Trp Phe  Val Ile Lys Asn Lys  Val Leu Tyr Thr Tyr  Ala Ala Ser 
    1355                 1360                 1365             


Glu Asp  Val Ala Ala Leu Glu  Ser Gln Pro Leu Leu  Gly Phe Thr 
    1370                 1375                 1380             


Val Ile  Gln Val Lys Asp Glu  Asn Ser Glu Ser Lys  Val Phe Gln 
    1385                 1390                 1395             


Leu Leu  His Lys Asn Met Leu  Phe Tyr Val Phe Lys  Ala Glu Asp 
    1400                 1405                 1410             


Ala His  Ser Ala Gln Lys Trp  Ile Glu Ala Phe Gln  Glu Gly Thr 
    1415                 1420                 1425             


Ile Leu  
    1430 


<210> 5763
<211> 546
<212> PRT
<213> Homo sapiens

<400> 5763
Met Gly Ala Tyr Leu Ser Gln Pro Asn Thr Val Lys Cys Ser Gly Asp 
1               5                   10                  15      


Gly Val Gly Ala Pro Arg Leu Pro Leu Pro Tyr Gly Phe Ser Ala Met 
            20                  25                  30          


Gln Gly Trp Arg Val Ser Met Glu Asp Ala His Asn Cys Ile Pro Glu 
        35                  40                  45              


Leu Asp Ser Glu Thr Ala Met Phe Ser Val Tyr Asp Gly His Gly Gly 
    50                  55                  60                  


Glu Glu Val Ala Leu Tyr Cys Ala Lys Tyr Leu Pro Asp Ile Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Ala Tyr Lys Glu Gly Lys Leu Gln Lys Ala Leu Glu Asp 
                85                  90                  95      


Ala Phe Leu Ala Ile Asp Ala Lys Leu Thr Thr Glu Glu Val Ile Lys 
            100                 105                 110         


Glu Leu Ala Gln Ile Ala Gly Arg Pro Thr Glu Asp Glu Asp Glu Lys 
        115                 120                 125             


Glu Lys Val Ala Asp Glu Asp Asp Val Asp Asn Glu Glu Ala Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ala Thr Met Thr Ile Glu Glu Leu Leu Thr Arg Tyr 
145                 150                 155                 160 


Gly Gln Asn Cys His Lys Gly Pro Pro His Ser Lys Ser Gly Gly Gly 
                165                 170                 175     


Thr Gly Glu Glu Pro Gly Ser Gln Gly Leu Asn Gly Glu Ala Gly Pro 
            180                 185                 190         


Glu Asp Ser Thr Arg Glu Thr Pro Ser Gln Glu Asn Gly Pro Thr Ala 
        195                 200                 205             


Lys Ala Tyr Thr Gly Phe Ser Ser Asn Ser Glu Arg Gly Thr Glu Ala 
    210                 215                 220                 


Gly Gln Val Gly Glu Pro Gly Ile Pro Thr Gly Glu Ala Gly Pro Ser 
225                 230                 235                 240 


Cys Ser Ser Ala Ser Asp Lys Leu Pro Arg Val Ala Lys Ser Lys Phe 
                245                 250                 255     


Phe Glu Asp Ser Glu Asp Glu Ser Asp Glu Ala Glu Glu Glu Glu Glu 
            260                 265                 270         


Asp Ser Glu Glu Cys Ser Glu Glu Glu Asp Gly Tyr Ser Ser Glu Glu 
        275                 280                 285             


Ala Glu Asn Glu Glu Asp Glu Asp Asp Thr Glu Glu Ala Glu Glu Asp 
    290                 295                 300                 


Asp Glu Glu Glu Glu Glu Glu Met Met Val Pro Gly Met Glu Gly Lys 
305                 310                 315                 320 


Glu Glu Pro Gly Ser Asp Ser Gly Thr Thr Ala Val Val Ala Leu Ile 
                325                 330                 335     


Arg Gly Lys Gln Leu Ile Val Ala Asn Ala Gly Asp Ser Arg Cys Val 
            340                 345                 350         


Val Ser Glu Ala Gly Lys Ala Leu Asp Met Ser Tyr Asp His Lys Pro 
        355                 360                 365             


Glu Asp Glu Val Glu Leu Ala Arg Ile Lys Asn Ala Gly Gly Lys Val 
    370                 375                 380                 


Thr Met Asp Gly Arg Val Asn Gly Gly Leu Asn Leu Ser Arg Ala Ile 
385                 390                 395                 400 


Gly Asp His Phe Tyr Lys Arg Asn Lys Asn Leu Pro Pro Glu Glu Gln 
                405                 410                 415     


Met Ile Ser Ala Leu Pro Asp Ile Lys Val Leu Thr Leu Thr Asp Asp 
            420                 425                 430         


His Glu Phe Met Val Ile Ala Cys Asp Gly Ile Trp Asn Val Met Ser 
        435                 440                 445             


Ser Gln Glu Val Val Asp Phe Ile Gln Ser Lys Ile Ser Gln Arg Asp 
    450                 455                 460                 


Glu Asn Gly Glu Leu Arg Leu Leu Ser Ser Ile Val Glu Glu Leu Leu 
465                 470                 475                 480 


Asp Gln Cys Leu Ala Pro Asp Thr Ser Gly Asp Gly Thr Gly Cys Asp 
                485                 490                 495     


Asn Met Thr Cys Ile Ile Ile Cys Phe Lys Pro Arg Asn Thr Ala Glu 
            500                 505                 510         


Leu Gln Pro Glu Ser Gly Lys Arg Lys Leu Glu Glu Val Leu Ser Thr 
        515                 520                 525             


Glu Gly Ala Glu Glu Asn Gly Asn Ser Asp Lys Lys Lys Lys Ala Lys 
    530                 535                 540                 


Arg Asp 
545     


<210> 5764
<211> 90
<212> PRT
<213> Homo sapiens

<400> 5764
Met Ser Thr Ala Met Asn Phe Gly Thr Lys Ser Phe Gln Pro Arg Pro 
1               5                   10                  15      


Pro Asp Lys Gly Ser Phe Pro Leu Asp His Leu Gly Glu Cys Lys Ser 
            20                  25                  30          


Phe Lys Glu Lys Phe Met Lys Cys Leu His Asn Asn Asn Phe Glu Asn 
        35                  40                  45              


Ala Leu Cys Arg Lys Glu Ser Lys Glu Tyr Leu Glu Cys Arg Met Glu 
    50                  55                  60                  


Arg Lys Leu Met Leu Gln Glu Pro Leu Glu Lys Leu Gly Phe Gly Asp 
65                  70                  75                  80  


Leu Thr Ser Gly Lys Ser Glu Ala Lys Lys 
                85                  90  


<210> 5765
<211> 241
<212> PRT
<213> Homo sapiens

<400> 5765
Met Asn Ser Gly Arg Pro Glu Thr Met Glu Asn Leu Pro Ala Leu Tyr 
1               5                   10                  15      


Thr Ile Phe Gln Gly Glu Val Ala Met Val Thr Asp Tyr Gly Ala Phe 
            20                  25                  30          


Ile Lys Ile Pro Gly Cys Arg Lys Gln Gly Leu Val His Arg Thr His 
        35                  40                  45              


Met Ser Ser Cys Arg Val Asp Lys Pro Ser Glu Ile Val Asp Val Gly 
    50                  55                  60                  


Asp Lys Val Trp Val Lys Leu Ile Gly Arg Glu Met Lys Asn Asp Arg 
65                  70                  75                  80  


Ile Lys Val Ser Leu Ser Met Lys Val Val Asn Gln Gly Thr Gly Lys 
                85                  90                  95      


Asp Leu Asp Pro Asn Asn Val Ile Ile Glu Gln Glu Glu Arg Arg Arg 
            100                 105                 110         


Arg Ser Phe Gln Asp Tyr Thr Gly Gln Lys Ile Thr Leu Glu Ala Val 
        115                 120                 125             


Leu Asn Thr Thr Cys Lys Lys Cys Gly Cys Lys Gly His Phe Ala Lys 
    130                 135                 140                 


Asp Cys Phe Met Gln Pro Gly Gly Thr Lys Tyr Ser Leu Ile Pro Asp 
145                 150                 155                 160 


Glu Glu Glu Glu Lys Glu Glu Ala Lys Ser Ala Glu Phe Glu Lys Pro 
                165                 170                 175     


Asp Pro Thr Arg Asn Pro Ser Arg Lys Arg Lys Lys Glu Lys Lys Lys 
            180                 185                 190         


Lys Lys His Arg Asp Arg Lys Ser Ser Asp Ser Asp Ser Ser Asp Ser 
        195                 200                 205             


Glu Ser Asp Thr Gly Lys Arg Ala Arg His Thr Ser Lys Asp Ser Lys 
    210                 215                 220                 


Ala Ala Lys Lys Lys Lys Lys Lys Lys Lys His Lys Lys Lys His Lys 
225                 230                 235                 240 


Glu 
    


<210> 5766
<211> 585
<212> PRT
<213> Homo sapiens

<400> 5766
Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Thr Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Thr Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Thr Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Thr Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg 
        115                 120                 125             


Gly His Thr Leu Glu Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln 
145                 150                 155                 160 


Asn Met Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile 
                165                 170                 175     


Leu Gln Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly 
            180                 185                 190         


Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg 
        195                 200                 205             


Lys Ile Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val 
    210                 215                 220                 


Leu Val Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly 
225                 230                 235                 240 


Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser 
                245                 250                 255     


Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr 
            260                 265                 270         


Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr 
        275                 280                 285             


Ile Gly Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met 
    290                 295                 300                 


Glu Gln Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly 
305                 310                 315                 320 


Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg 
                325                 330                 335     


Gln Pro Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser 
            340                 345                 350         


Val Lys Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His 
        355                 360                 365             


Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val 
    370                 375                 380                 


His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met 
385                 390                 395                 400 


Thr Val Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr 
                405                 410                 415     


Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp 
            420                 425                 430         


Thr Leu Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr 
        435                 440                 445             


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser 
    450                 455                 460                 


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr 
465                 470                 475                 480 


Pro Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met 
                485                 490                 495     


Trp Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
            500                 505                 510         


Gly Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
        515                 520                 525             


Ser Val Gly His Asn Asn Leu Ile Pro Leu Gly Ser Ser Gly Ala Gln 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Thr Ser Ala His Tyr Ala Val Asn Ser Gln 
545                 550                 555                 560 


Phe Thr Met Gly Gly Pro Ala Ile Ser Met Ala Ser Pro Met Ser Ile 
                565                 570                 575     


Pro Thr Asn Thr Met His Tyr Gly Ser 
            580                 585 


<210> 5767
<211> 256
<212> PRT
<213> Homo sapiens

<400> 5767
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 5768
<211> 1430
<212> PRT
<213> Homo sapiens

<400> 5768
Met Cys Leu Glu Ser Asn Leu Ser Ser Cys Lys His Leu Pro Cys Cys 
1               5                   10                  15      


Gly Lys Leu His Phe Gln Ser Cys His Gly Asn Val His Lys Leu His 
            20                  25                  30          


Gln Phe Pro Ser Leu Gln Gly Cys Thr Ser Ala Gly Tyr Phe Pro Cys 
        35                  40                  45              


Ser Asp Phe Thr Ser Gly Ala Pro Gly His Leu Glu Glu His Ile Ser 
    50                  55                  60                  


Gln Ser Glu Leu Thr Pro His Leu Cys Thr Asn Ser Leu His Leu Asn 
65                  70                  75                  80  


Val Val Pro Pro Val Cys Leu Lys Gly Ser Leu Tyr Cys Glu Asp Cys 
                85                  90                  95      


Leu Asn Lys Pro Ala Arg Asn Ser Ile Ile Asp Ala Ala Lys Val Trp 
            100                 105                 110         


Pro Asn Ile Pro Pro Pro Asn Thr Gln Pro Ala Pro Leu Ala Val Pro 
        115                 120                 125             


Leu Cys Asn Gly Cys Gly Thr Lys Gly Thr Gly Lys Glu Thr Thr Leu 
    130                 135                 140                 


Leu Leu Ala Thr Ser Leu Gly Lys Ala Ala Ser Lys Phe Gly Ser Pro 
145                 150                 155                 160 


Glu Val Ala Val Ala Gly Gln Val Leu Glu Asn Leu Pro Pro Ile Gly 
                165                 170                 175     


Val Phe Trp Asp Ile Glu Asn Cys Ser Val Pro Ser Gly Arg Ser Ala 
            180                 185                 190         


Thr Ala Val Val Gln Arg Ile Arg Glu Lys Phe Phe Lys Gly His Arg 
        195                 200                 205             


Glu Ala Glu Phe Ile Cys Val Cys Asp Ile Ser Lys Glu Asn Lys Glu 
    210                 215                 220                 


Val Ile Gln Glu Leu Asn Asn Cys Gln Val Thr Val Ala His Ile Asn 
225                 230                 235                 240 


Ala Thr Ala Lys Asn Ala Ala Asp Asp Lys Leu Arg Gln Ser Leu Arg 
                245                 250                 255     


Arg Phe Ala Asn Thr His Thr Ala Pro Ala Thr Val Val Leu Val Ser 
            260                 265                 270         


Thr Asp Val Asn Phe Ala Leu Glu Leu Ser Asp Leu Arg His Arg His 
        275                 280                 285             


Gly Phe His Ile Ile Leu Val His Lys Asn Gln Ala Ser Glu Ala Leu 
    290                 295                 300                 


Leu His His Ala Asn Glu Leu Ile Arg Phe Glu Glu Phe Ile Ser Asp 
305                 310                 315                 320 


Leu Pro Pro Arg Leu Pro Leu Lys Met Pro Gln Cys His Thr Leu Leu 
                325                 330                 335     


Tyr Val Tyr Asn Leu Pro Ala Asn Lys Asp Gly Lys Ser Val Ser Asn 
            340                 345                 350         


Arg Leu Arg Arg Leu Ser Asp Asn Cys Gly Gly Lys Val Leu Ser Ile 
        355                 360                 365             


Thr Gly Cys Ser Ala Ile Leu Arg Phe Ile Asn Gln Asp Ser Ala Glu 
    370                 375                 380                 


Arg Ala Gln Lys Arg Met Glu Asn Glu Asp Val Phe Glu Lys Lys Asp 
385                 390                 395                 400 


Lys Glu Glu Thr Val Phe Gln Val Ser Tyr Pro Ser Ala Phe Ser Lys 
                405                 410                 415     


Leu Val Ala Ser Arg Gln Val Ser Pro Leu Leu Ala Ser Gln Ser Trp 
            420                 425                 430         


Ser Ser Arg Ala Ser Pro Leu Ala Phe Asn Ile Ala Asn Ser Ser Ser 
        435                 440                 445             


Glu Ala Asp Cys Pro Asp Pro Phe Ala Asn Gly Ala Asp Val Gln Val 
    450                 455                 460                 


Ser Asn Ile Asp Tyr Arg Leu Ser Arg Lys Glu Leu Gln Gln Leu Leu 
465                 470                 475                 480 


Gln Glu Ala Phe Ala Arg His Gly Lys Val Lys Ser Val Glu Leu Ser 
                485                 490                 495     


Pro His Thr Asp Tyr Gln Leu Lys Ala Val Val Gln Met Glu Asn Leu 
            500                 505                 510         


Gln Asp Ala Ile Gly Ala Val Asn Ser Leu His Arg Tyr Lys Ile Gly 
        515                 520                 525             


Ser Lys Lys Ile Leu Val Ser Leu Ala Thr Gly Ala Ala Ser Lys Ser 
    530                 535                 540                 


Leu Ser Leu Leu Arg Phe Gly His Lys Leu Asn Val Ser Asp Leu Tyr 
545                 550                 555                 560 


Lys Leu Thr Asp Thr Val Ala Ile Arg Glu Gln Gly Asn Gly Arg Leu 
                565                 570                 575     


Val Cys Leu Leu Pro Ser Ser Gln Ala Arg Gln Ser Pro Leu Gly Ser 
            580                 585                 590         


Ser Gln Ser His Asp Gly Ser Ser Thr Asn Cys Ser Pro Ile Ile Phe 
        595                 600                 605             


Glu Glu Leu Glu Tyr His Glu Pro Val Cys Arg Gln His Cys Ser Asn 
    610                 615                 620                 


Lys Asp Phe Ser Phe Pro Asp Cys Tyr Ile Ala Glu Phe Gly Asp Leu 
625                 630                 635                 640 


Glu Val Val Gln Glu Asn Gln Gly Gly Val Pro Leu Glu His Phe Ile 
                645                 650                 655     


Thr Cys Val Pro Gly Val Asn Ile Ala Thr Ala Gln Asn Gly Ile Lys 
            660                 665                 670         


Val Val Lys Trp Ile His Asn Lys Pro Pro Pro Pro Asn Thr Asp Pro 
        675                 680                 685             


Trp Leu Leu Arg Ser Lys Ser Pro Val Gly Asn Pro Gln Leu Ile Gln 
    690                 695                 700                 


Phe Ser Arg Glu Val Ile Asp Leu Leu Lys Ser Gln Pro Ser Cys Val 
705                 710                 715                 720 


Ile Pro Ile Ser His Phe Ile Pro Ser Tyr His His His Phe Ala Lys 
                725                 730                 735     


Gln Cys Arg Val Ser Asp Tyr Gly Tyr Ser Lys Leu Ile Glu Leu Leu 
            740                 745                 750         


Glu Ala Val Pro His Val Leu Gln Ile Leu Gly Met Gly Ser Lys Arg 
        755                 760                 765             


Leu Leu Thr Leu Thr His Arg Ala Gln Val Lys Arg Phe Thr Gln Asp 
    770                 775                 780                 


Leu Leu Lys Leu Leu Lys Ser Gln Ala Ser Lys Gln Val Ile Val Arg 
785                 790                 795                 800 


Glu Phe Ser Gln Ala Tyr His Trp Cys Phe Ser Lys Asp Trp Asp Val 
                805                 810                 815     


Thr Glu Tyr Gly Val Cys Glu Leu Ile Asp Ile Val Ser Glu Ile Pro 
            820                 825                 830         


Asp Thr Thr Ile Cys Leu Ser Gln Gln Asp Asn Glu Met Val Ile Cys 
        835                 840                 845             


Ile Pro Lys Arg Glu Arg Thr Gln Asp Glu Ile Glu Arg Thr Lys Gln 
    850                 855                 860                 


Phe Ser Lys Asp Val Val Asp Leu Leu Arg His Gln Pro His Phe Arg 
865                 870                 875                 880 


Met Pro Phe Asn Lys Phe Ile Pro Ser Tyr His His His Phe Gly Arg 
                885                 890                 895     


Gln Cys Lys Leu Ala Tyr Tyr Gly Phe Thr Lys Leu Leu Glu Leu Phe 
            900                 905                 910         


Glu Ala Ile Pro Asp Thr Leu Gln Val Leu Glu Cys Gly Glu Glu Lys 
        915                 920                 925             


Ile Leu Thr Leu Thr Glu Val Glu Arg Phe Lys Ala Leu Ala Ala Gln 
    930                 935                 940                 


Phe Val Lys Leu Leu Arg Ser Gln Lys Asp Asn Cys Leu Met Met Thr 
945                 950                 955                 960 


Asp Leu Leu Thr Glu Tyr Ala Lys Thr Phe Gly Tyr Thr Phe Arg Leu 
                965                 970                 975     


Gln Asp Tyr Asp Val Ser Ser Ile Ser Ala Leu Thr Gln Lys Leu Cys 
            980                 985                 990         


His Val Val Lys Val Ala Asp Ile  Glu Ser Gly Arg Gln  Ile Gln Leu 
        995                 1000                 1005             


Ile Asn  Arg Lys Ser Leu Arg  Ser Leu Thr Ala Gln  Leu Leu Val 
    1010                 1015                 1020             


Leu Leu  Met Ser Trp Glu Gly  Thr Thr His Leu Ser  Val Glu Glu 
    1025                 1030                 1035             


Leu Lys  Arg His Tyr Glu Ser  Thr His Asn Thr Pro  Leu Asn Pro 
    1040                 1045                 1050             


Cys Glu  Tyr Gly Phe Met Thr  Leu Thr Glu Leu Leu  Lys Ser Leu 
    1055                 1060                 1065             


Pro Tyr  Leu Val Glu Thr Ala  Ala Ala Phe Asp Leu  Gln Ile Glu 
    1070                 1075                 1080             


Leu Lys  Phe Ala Gly Gly Tyr  Ser Leu Leu Leu Glu  Glu Ile Leu 
    1085                 1090                 1095             


Glu Tyr  Ile Pro Pro Pro Phe  Leu Ser Pro Leu Pro  Ser Phe Leu 
    1100                 1105                 1110             


Pro Pro  Pro Pro Phe Phe Phe  Phe Val Phe Phe Val  Ile Phe Ile 
    1115                 1120                 1125             


Phe Phe  Ile Phe Val Phe Val  Gln Phe Val Val Phe  Val Phe Phe 
    1130                 1135                 1140             


Ile Val  Val Phe Val Phe Phe  Ile Val Val Phe Val  Phe Thr Asn 
    1145                 1150                 1155             


Asp Lys  Met Glu Glu Cys Val  Lys Leu Thr Ser Leu  Tyr Leu Phe 
    1160                 1165                 1170             


Ala Lys  Asn Val Arg Ser Leu  Leu His Thr Tyr His  Tyr Gln Gln 
    1175                 1180                 1185             


Ile Phe  Leu His Glu Phe Ser  Met Ala Tyr Thr Lys  Tyr Val Gly 
    1190                 1195                 1200             


Glu Thr  Leu Gln Pro Lys Thr  Tyr Gly His Ser Ser  Val Glu Glu 
    1205                 1210                 1215             


Leu Leu  Gly Ala Ile Pro Gln  Val Val Val Gln Phe  Leu Gln Lys 
    1220                 1225                 1230             


Asn Gly  Lys Glu Leu Ser Cys  Glu Asn Tyr Leu Asn  Leu Tyr Ala 
    1235                 1240                 1245             


Lys Ala  Gly Arg Leu Ser Ser  Leu Ser Leu Ser Pro  Ala Asn His 
    1250                 1255                 1260             


Glu Asn  Gln Pro Ser Glu Gly  Glu Arg Ile Leu Glu  Val Pro Glu 
    1265                 1270                 1275             


Ser His  Thr Ala Ser Glu Leu  Lys Leu Gly Ala Asp  Gly Ser Gly 
    1280                 1285                 1290             


Pro Ser  His Thr Glu Gln Glu  Leu Leu Arg Leu Thr  Asp Asp Ser 
    1295                 1300                 1305             


Pro Val  Asp Leu Leu Cys Ala  Pro Val Pro Ser Cys  Leu Pro Ser 
    1310                 1315                 1320             


Pro Gln  Leu Arg Pro Asp Pro  Val Ile Leu Gln Ser  Ala Asp Leu 
    1325                 1330                 1335             


Ile Gln  Phe Glu Glu Arg Pro  Gln Glu Pro Ser Glu  Ile Met Ile 
    1340                 1345                 1350             


Leu Asn  Gln Glu Glu Lys Met  Glu Ile Pro Ile Pro  Gly Lys Ser 
    1355                 1360                 1365             


Lys Thr  Leu Thr Ser Asp Ser  Ser Ser Ser Cys Ile  Ser Ala Ala 
    1370                 1375                 1380             


Val Pro  Val Pro Pro Cys Pro  Ser Ser Glu Thr Ser  Glu Ser Leu 
    1385                 1390                 1395             


Leu Ser  Lys Asp Pro Val Glu  Ser Pro Ala Lys Lys  Gln Pro Lys 
    1400                 1405                 1410             


Asn Arg  Val Lys Leu Ala Ala  Asn Phe Ser Leu Ala  Pro Ile Thr 
    1415                 1420                 1425             


Lys Leu  
    1430 


<210> 5769
<211> 781
<212> PRT
<213> Homo sapiens

<400> 5769
Met Gly Gln Leu Arg Asp Trp Phe Pro Asn Thr Gln Asp Leu Ala Gly 
1               5                   10                  15      


Asn Asp Gln Glu Asn Ile Arg His Ala Asp Arg Asn Asn Ser Asp Asp 
            20                  25                  30          


Asn His Leu Ala Ser Glu Asp Thr Ser Ala Lys Gln Ser Gly Lys Pro 
        35                  40                  45              


Gly Ile Tyr Glu Asp Arg Asp Pro Leu Arg Val Ser Ile Ser Arg Glu 
    50                  55                  60                  


Gln Ser Phe Phe Gly Ser Pro Leu Ala His Asp Pro Phe Ser Cys Leu 
65                  70                  75                  80  


Gln Leu Val Gly Gln Glu Asn Val Cys Gly Asp Asp Tyr Asp Glu Ala 
                85                  90                  95      


Val Lys Leu Lys Glu Ser Val Val Glu Asn His Ala Val Leu Ser Tyr 
            100                 105                 110         


Ala Val Glu Glu Glu His Ala Tyr Leu Gly Pro Thr Val Lys Pro Asp 
        115                 120                 125             


Asp Lys Ala Lys Thr Leu Ser Tyr Glu Pro Leu Ser Ser Ala Thr Val 
    130                 135                 140                 


Ser Thr Gly Ser Leu Leu Ser Tyr Glu Asn Thr Asp Leu Ser Leu Thr 
145                 150                 155                 160 


Asp Pro Glu Ser Phe Ser Glu His Met Asp Asp Ser Lys Gln Glu Ser 
                165                 170                 175     


Thr Thr Ser Lys Glu Glu Glu Thr Asn Ile Ile Ser Ser Ile Val Pro 
            180                 185                 190         


Ser Thr Gln Asp Ile Tyr Gln Arg Gln Asn Ser Ser Asp Val His Lys 
        195                 200                 205             


Ser Leu Leu Pro Ala Val Asp Glu Thr Thr Cys Gly His Thr His Phe 
    210                 215                 220                 


Gln Gln Met Ile Asp Lys Tyr Ile Asn Glu Ala Asn Leu Ile Pro Glu 
225                 230                 235                 240 


Lys Thr Asp Leu Gln Glu Leu Glu His Ile Phe Pro Asn Leu His His 
                245                 250                 255     


Gln Leu Phe Lys Pro Leu Glu Pro His Pro Asp Phe Asp Leu Ser Ser 
            260                 265                 270         


Ser Ser Ser Gly Ile Ser Pro Asp Asn Arg Asp Phe Tyr Gln Arg Ser 
        275                 280                 285             


Asp Ser Ser Ser Glu Ser His Cys Ala Thr Gly Leu Ser Lys Ser Thr 
    290                 295                 300                 


Val Tyr Phe Thr Ala Leu Arg Arg Thr Ser Met His Ser Ser Leu Asn 
305                 310                 315                 320 


Thr Ser Pro Asn Gln Gln Pro Asp Thr Asn Leu Ala His Val Gly Ala 
                325                 330                 335     


His Ser Phe Ala Thr Glu Asn Ile Ile Gly Gly Ser Glu Gln Cys Phe 
            340                 345                 350         


Glu Gln Leu Gln Pro Glu Tyr Ser Ser Gln Glu Glu Ser Gln His Ala 
        355                 360                 365             


Asp Leu Pro Ser Ile Phe Ser Ile Glu Ala Arg Asp Ser Ser Gln Gly 
    370                 375                 380                 


Met Lys Asn Gln Asn Tyr Pro Ser Glu Glu His Thr Glu Ile Leu Gln 
385                 390                 395                 400 


Asn Lys Lys Lys Ile Val His Phe Gln Leu Ser Ile Gly Asn Leu Ser 
                405                 410                 415     


Ser Val Tyr Ser Ser Ser Asp Glu Ala Asn Val Phe Asp Gln Leu Asn 
            420                 425                 430         


Val Gln His Ser Thr Pro Cys Gly Ser Asn Ser Ser Glu Cys Ser Thr 
        435                 440                 445             


Lys His Gln Leu Glu Ser Arg Lys Glu Ser Met Gly Phe Glu Glu Leu 
    450                 455                 460                 


Ser Lys Arg Gly Val Val Thr Met Leu Gln Ser Gln Gly Leu Ile Glu 
465                 470                 475                 480 


Asp Asn Lys Asn Glu Thr Cys Arg Val Leu Asp Ile Asn Pro Gln Val 
                485                 490                 495     


Glu Glu Thr Asp Ser Arg Leu Cys Val Arg Thr Val Glu Met Gly Thr 
            500                 505                 510         


Ser Ile Gln Ala Pro Tyr Ser Leu Thr Thr Gln Asn Glu Lys Tyr Phe 
        515                 520                 525             


Glu Asn Ser Ala Glu Thr Asp Ile Pro Lys Ile Thr Lys Lys Leu Ser 
    530                 535                 540                 


Gln Leu Gly Glu Ser Glu Leu Phe Ala Ser Ser Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Gln Ser Ser Ile Pro Val Trp Glu Thr Glu Thr Gly His Gly Ile Met 
                565                 570                 575     


Glu Glu Pro Glu Leu Thr Leu Ile Ser Thr Thr Asp Thr Ser Ile Ala 
            580                 585                 590         


Glu Met Asp Phe Ala Asn Leu Thr Leu Glu Glu Lys Ser Glu Asn Glu 
        595                 600                 605             


Ala Lys Cys Phe Phe Gln Val Ser Glu Phe Leu Pro Leu Val Ser Ala 
    610                 615                 620                 


Thr Glu Ala Ser Asp Tyr Pro Ala Val Ser Glu Leu Ser Ile Glu Lys 
625                 630                 635                 640 


Pro Arg Thr Ala Ser Thr Glu Thr Pro Arg Arg Leu Thr Pro Val Pro 
                645                 650                 655     


Gly Ser Leu Gln Glu Ala Phe Ile Lys Arg Lys Lys Ser Phe Met Glu 
            660                 665                 670         


Arg Ser His Gln Arg Gln Lys Glu Ile Arg Asn Lys Ile His Val Ser 
        675                 680                 685             


Glu Asn Ser Gln Ile Lys Thr Val Lys Glu Lys Pro Ser Ile Ser Ser 
    690                 695                 700                 


Ser Val Ser Arg Leu Lys Gly Val Asn Lys Val Arg Ala Ser Phe Pro 
705                 710                 715                 720 


Glu Asp Arg Lys Thr Thr Gln Ala Leu Arg His Gln Arg Gly Leu Arg 
                725                 730                 735     


Leu Tyr Asn Gln Leu Ala Glu Val Lys Gln Gln Lys Glu Glu Lys Thr 
            740                 745                 750         


Lys Gln Glu Ala Tyr Ala Gln Asn Arg Ala Arg Ala Lys Glu Phe His 
        755                 760                 765             


Lys Lys Thr Leu Glu Lys Leu Arg Ala Lys Asn Thr Cys 
    770                 775                 780     


<210> 5770
<211> 170
<212> PRT
<213> Homo sapiens

<400> 5770
Met Gly Lys Arg Tyr Phe Cys Asp Tyr Cys Asp Arg Ser Phe Gln Asp 
1               5                   10                  15      


Asn Leu His Asn Arg Lys Lys His Leu Asn Gly Leu Gln His Leu Lys 
            20                  25                  30          


Ala Lys Lys Val Trp Tyr Asp Met Phe Arg Asp Ala Ala Ala Ile Leu 
        35                  40                  45              


Leu Asp Glu Gln Asn Lys Arg Pro Cys Arg Lys Phe Leu Leu Thr Gly 
    50                  55                  60                  


Gln Cys Asp Phe Gly Ser Asn Cys Arg Phe Ser His Met Ser Glu Arg 
65                  70                  75                  80  


Asp Leu Gln Glu Leu Ser Ile Gln Val Glu Glu Glu Arg Arg Ala Arg 
                85                  90                  95      


Glu Trp Leu Leu Asp Ala Pro Glu Leu Pro Glu Gly His Leu Glu Asp 
            100                 105                 110         


Trp Leu Glu Lys Arg Ala Lys Arg Leu Ser Ser Ala Pro Ser Ser Arg 
        115                 120                 125             


Ala Glu Pro Ile Arg Thr Thr Val Phe Gln Tyr Pro Val Gly Trp Pro 
    130                 135                 140                 


Pro Val Gln Glu Leu Pro Pro Ser Leu Arg Ala Pro Pro Pro Gly Gly 
145                 150                 155                 160 


Trp Pro Leu Gln Pro Arg Val Gln Trp Gly 
                165                 170 


<210> 5771
<211> 513
<212> PRT
<213> Homo sapiens

<400> 5771
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr Thr 
        35                  40                  45              


Ser Asp Asp Thr Pro Cys Gln Glu Gln Pro Lys Glu Val Leu Lys Ala 
    50                  55                  60                  


Pro Ser Thr Ser Gly Leu Gln Gln Val Ala Phe Gln Pro Gly Gln Lys 
65                  70                  75                  80  


Val Tyr Val Trp Tyr Gly Gly Gln Glu Cys Thr Gly Leu Val Glu Gln 
                85                  90                  95      


His Ser Trp Met Glu Gly Gln Val Thr Val Trp Leu Leu Glu Gln Lys 
            100                 105                 110         


Leu Gln Val Cys Cys Arg Val Glu Glu Val Trp Leu Ala Glu Leu Gln 
        115                 120                 125             


Gly Pro Cys Pro Gln Ala Pro Pro Leu Glu Pro Gly Ala Gln Ala Leu 
    130                 135                 140                 


Ala Tyr Arg Pro Val Ser Arg Asn Ile Asp Val Pro Lys Arg Lys Ser 
145                 150                 155                 160 


Asp Ala Val Glu Met Asp Glu Met Met Ala Ala Met Val Leu Thr Ser 
                165                 170                 175     


Leu Ser Cys Ser Pro Val Val Gln Ser Pro Pro Gly Thr Glu Ala Asn 
            180                 185                 190         


Phe Ser Ala Ser Arg Ala Ala Cys Asp Pro Trp Lys Glu Ser Gly Asp 
        195                 200                 205             


Ile Ser Asp Ser Gly Ser Ser Thr Thr Ser Gly His Trp Ser Gly Ser 
    210                 215                 220                 


Ser Gly Val Ser Thr Pro Ser Pro Pro His Pro Gln Ala Ser Pro Lys 
225                 230                 235                 240 


Tyr Leu Gly Asp Ala Phe Gly Ser Pro Gln Thr Asp His Gly Phe Glu 
                245                 250                 255     


Thr Asp Pro Asp Pro Phe Leu Leu Asp Glu Pro Ala Pro Arg Lys Arg 
            260                 265                 270         


Lys Asn Ser Val Lys Val Met Tyr Lys Cys Leu Trp Pro Asn Cys Gly 
        275                 280                 285             


Lys Val Leu Arg Ser Ile Val Gly Ile Lys Arg His Val Lys Ala Leu 
    290                 295                 300                 


His Leu Gly Asp Thr Val Asp Ser Asp Gln Phe Lys Arg Glu Glu Asp 
305                 310                 315                 320 


Phe Tyr Tyr Thr Glu Val Gln Leu Lys Glu Glu Ser Ala Ala Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Gly Thr Pro Val Pro Gly Thr Pro Thr Ser Glu 
            340                 345                 350         


Pro Ala Pro Thr Pro Ser Met Thr Gly Leu Pro Leu Ser Ala Leu Pro 
        355                 360                 365             


Pro Pro Leu His Lys Ala Gln Ser Ser Gly Pro Glu His Pro Gly Pro 
    370                 375                 380                 


Glu Ser Ser Leu Pro Ser Gly Ala Leu Ser Lys Ser Ala Pro Gly Ser 
385                 390                 395                 400 


Phe Trp His Ile Gln Ala Asp His Ala Tyr Gln Ala Leu Pro Ser Phe 
                405                 410                 415     


Gln Ile Pro Val Ser Pro His Ile Tyr Thr Ser Val Ser Trp Ala Ala 
            420                 425                 430         


Ala Pro Ser Ala Ala Cys Ser Leu Ser Pro Val Arg Ser Arg Ser Leu 
        435                 440                 445             


Ser Phe Ser Glu Pro Gln Gln Pro Ala Pro Ala Met Lys Ser His Leu 
    450                 455                 460                 


Ile Val Thr Ser Pro Pro Arg Ala Gln Ser Gly Ala Arg Lys Ala Arg 
465                 470                 475                 480 


Gly Glu Ala Lys Lys Cys Arg Lys Val Tyr Gly Ile Glu His Arg Asp 
                485                 490                 495     


Gln Trp Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg Phe Leu 
            500                 505                 510         


Asp 
    


<210> 5772
<211> 184
<212> PRT
<213> Homo sapiens

<400> 5772
Met Gly Asn Gly Met Asn Lys Ile Leu Pro Gly Leu Tyr Ile Gly Asn 
1               5                   10                  15      


Phe Lys Asp Ala Arg Asp Ala Glu Gln Leu Ser Lys Asn Lys Val Thr 
            20                  25                  30          


His Ile Leu Ser Val His Asp Ser Ala Arg Pro Met Leu Glu Gly Val 
        35                  40                  45              


Lys Tyr Leu Cys Ile Pro Ala Ala Asp Ser Pro Ser Gln Asn Leu Thr 
    50                  55                  60                  


Arg His Phe Lys Glu Ser Ile Lys Phe Ile His Glu Cys Arg Leu Arg 
65                  70                  75                  80  


Gly Glu Ser Cys Leu Val His Cys Leu Ala Gly Val Ser Arg Ser Val 
                85                  90                  95      


Thr Leu Val Ile Ala Tyr Ile Met Thr Val Thr Asp Phe Gly Trp Glu 
            100                 105                 110         


Asp Ala Leu His Thr Val Arg Ala Gly Arg Ser Cys Ala Asn Pro Asn 
        115                 120                 125             


Val Gly Phe Gln Arg Gln Leu Gln Glu Phe Glu Lys His Glu Val His 
    130                 135                 140                 


Gln Tyr Arg Gln Trp Leu Lys Glu Glu Tyr Gly Glu Ser Pro Leu Gln 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Lys Asn Ile Leu Ala Ala Pro Gly Ile Leu Lys 
                165                 170                 175     


Phe Trp Ala Phe Leu Arg Arg Leu 
            180                 


<210> 5773
<211> 213
<212> PRT
<213> Homo sapiens

<400> 5773
Met Leu Gln Leu Arg Asp Ser Val Asp Ser Ala Gly Thr Ser Pro Thr 
1               5                   10                  15      


Ala Val Leu Ala Ala Gly Glu Glu Val Gly Ala Gly Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Arg Pro Gly Ala Gly Thr Pro Leu Arg Gln Thr Leu Trp Pro 
        35                  40                  45              


Leu Ser Ile His Asp Pro Thr Arg Arg Ala Arg Val Lys Glu Tyr Phe 
    50                  55                  60                  


Val Phe Arg Pro Gly Ser Ile Glu Gln Ala Val Glu Glu Ile Arg Val 
65                  70                  75                  80  


Val Val Arg Pro Val Glu Asp Gly Glu Ile Gln Gly Val Trp Leu Leu 
                85                  90                  95      


Thr Glu Arg Glu Gly Phe Gly Ile Arg Ile Gln Trp Asp Lys Gln Ser 
            100                 105                 110         


Arg Pro Ser Phe Ile Asn Arg Trp Asn Pro Trp Ser Thr Asn Val Pro 
        115                 120                 125             


Tyr Ala Thr Phe Thr Glu His Pro Met Ala Gly Ala Asp Glu Lys Thr 
    130                 135                 140                 


Ala Ser Leu Cys Gln Leu Glu Ser Phe Lys Ala Leu Leu Ile Gln Ala 
145                 150                 155                 160 


Val Lys Lys Ala Gln Lys Glu Ser Pro Leu Pro Gly Gln Ala Asn Gly 
                165                 170                 175     


Val Leu Ile Leu Glu Arg Pro Leu Leu Ile Glu Thr Tyr Val Gly Leu 
            180                 185                 190         


Met Ser Phe Ile Asn Asn Glu Ala Lys Leu Gly Tyr Ser Met Thr Arg 
        195                 200                 205             


Gly Lys Ile Gly Phe 
    210             


<210> 5774
<211> 295
<212> PRT
<213> Homo sapiens

<400> 5774
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 5775
<211> 1288
<212> PRT
<213> Homo sapiens

<400> 5775
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu 
                165                 170                 175     


Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp 
            180                 185                 190         


Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp 
        195                 200                 205             


Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg 
    210                 215                 220                 


Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro 
225                 230                 235                 240 


Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp 
                245                 250                 255     


Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg 
            260                 265                 270         


Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Leu Asn Arg Val 
        275                 280                 285             


Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn Ile 
    290                 295                 300                 


Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys Asn 
305                 310                 315                 320 


His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala Glu 
                325                 330                 335     


Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile Asn 
            340                 345                 350         


Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys Asp 
        355                 360                 365             


Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile Glu 
    370                 375                 380                 


Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln Val 
385                 390                 395                 400 


Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Lys Leu Glu Lys 
                405                 410                 415     


Gln Leu Gln Lys Asp Lys Glu Lys Val Glu Glu Phe Lys Ser Ile Pro 
            420                 425                 430         


Ala Lys Ser Asn Asn Ile Ile Asn Glu Thr Thr Thr Arg Asn Asn Ala 
        435                 440                 445             


Leu Glu Lys Glu Lys Glu Lys Glu Glu Lys Lys Leu Lys Glu Val Met 
    450                 455                 460                 


Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu Ser 
465                 470                 475                 480 


Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala Arg 
                485                 490                 495     


Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser Arg 
            500                 505                 510         


His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu Ile 
        515                 520                 525             


Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp Ile 
    530                 535                 540                 


Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu Val 
                565                 570                 575     


His Asp Leu Phe Gln Lys Val Glu Glu Ala Lys Ser Ser Leu Ala Met 
            580                 585                 590         


Asn Arg Ser Arg Gly Lys Val Leu Asp Ala Ile Ile Gln Glu Lys Lys 
        595                 600                 605             


Ser Gly Arg Ile Pro Gly Ile Tyr Gly Arg Leu Gly Asp Leu Gly Ala 
    610                 615                 620                 


Ile Asp Glu Lys Tyr Asp Val Ala Ile Ser Ser Cys Cys His Ala Leu 
625                 630                 635                 640 


Asp Tyr Ile Val Val Asp Ser Ile Asp Ile Ala Gln Glu Cys Val Asn 
                645                 650                 655     


Phe Leu Lys Arg Gln Asn Ile Gly Val Ala Thr Phe Ile Gly Leu Asp 
            660                 665                 670         


Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro Glu 
        675                 680                 685             


Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys Ile 
    690                 695                 700                 


Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp Asn 
705                 710                 715                 720 


Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp Arg 
                725                 730                 735     


Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met Thr 
            740                 745                 750         


Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu Val 
        755                 760                 765             


Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu Gln 
    770                 775                 780                 


Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln Leu 
785                 790                 795                 800 


Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg Asn 
                805                 810                 815     


Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln Glu 
            820                 825                 830         


Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu Ala 
        835                 840                 845             


Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val Ser 
    850                 855                 860                 


Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Gly Lys Val 
865                 870                 875                 880 


Glu Ala Glu Val Lys Arg Leu His Asn Thr Ile Val Glu Ile Asn Asn 
                885                 890                 895     


His Lys Leu Lys Ala Gln Gln Asp Lys Leu Asp Lys Ile Asn Lys Gln 
            900                 905                 910         


Leu Asp Glu Cys Ala Ser Ala Ile Thr Lys Ala Gln Val Ala Ile Lys 
        915                 920                 925             


Thr Ala Asp Arg Asn Leu Gln Lys Ala Gln Asp Ser Val Leu Arg Thr 
    930                 935                 940                 


Glu Lys Glu Ile Lys Asp Thr Glu Lys Glu Val Asp Asp Leu Thr Ala 
945                 950                 955                 960 


Glu Leu Lys Ser Leu Glu Asp Lys Ala Ala Glu Val Val Lys Asn Thr 
                965                 970                 975     


Asn Ala Ala Glu Glu Ser Leu Pro Glu Ile Gln Lys Glu His Arg Asn 
            980                 985                 990         


Leu Leu Gln Glu Leu Lys Val Ile  Gln Glu Asn Glu His  Ala Leu Gln 
        995                 1000                 1005             


Lys Asp  Ala Leu Ser Ile Lys  Leu Lys Leu Glu Gln  Ile Asp Gly 
    1010                 1015                 1020             


His Ile  Ala Glu His Asn Ser  Lys Ile Lys Tyr Trp  His Lys Glu 
    1025                 1030                 1035             


Ile Ser  Lys Ile Ser Leu His  Pro Ile Glu Asp Asn  Pro Ile Glu 
    1040                 1045                 1050             


Glu Ile  Ser Val Leu Ser Pro  Glu Asp Leu Glu Ala  Ile Lys Asn 
    1055                 1060                 1065             


Pro Asp  Ser Ile Thr Asn Gln  Ile Ala Leu Leu Glu  Ala Arg Cys 
    1070                 1075                 1080             


His Glu  Met Lys Pro Asn Leu  Gly Ala Ile Ala Glu  Tyr Lys Lys 
    1085                 1090                 1095             


Lys Glu  Glu Leu Tyr Leu Gln  Arg Val Ala Glu Leu  Asp Lys Ile 
    1100                 1105                 1110             


Thr Tyr  Glu Arg Asp Ser Phe  Arg Gln Ala Tyr Glu  Asp Leu Arg 
    1115                 1120                 1125             


Lys Gln  Arg Leu Asn Glu Phe  Met Ala Gly Phe Tyr  Ile Ile Thr 
    1130                 1135                 1140             


Asn Lys  Leu Lys Glu Asn Tyr  Gln Met Leu Thr Leu  Gly Gly Asp 
    1145                 1150                 1155             


Ala Glu  Leu Glu Leu Val Asp  Ser Leu Asp Pro Phe  Ser Glu Gly 
    1160                 1165                 1170             


Ile Met  Phe Ser Val Arg Pro  Pro Lys Lys Ser Trp  Lys Lys Ile 
    1175                 1180                 1185             


Phe Asn  Leu Ser Gly Gly Glu  Lys Thr Leu Ser Ser  Leu Ala Leu 
    1190                 1195                 1200             


Val Phe  Ala Leu His His Tyr  Lys Pro Thr Pro Leu  Tyr Phe Met 
    1205                 1210                 1215             


Asp Glu  Ile Asp Ala Ala Leu  Asp Phe Lys Asn Val  Ser Ile Val 
    1220                 1225                 1230             


Ala Phe  Tyr Ile Tyr Glu Gln  Thr Lys Asn Ala Gln  Phe Ile Ile 
    1235                 1240                 1245             


Ile Ser  Leu Arg Asn Asn Met  Phe Glu Ile Ser Asp  Arg Leu Ile 
    1250                 1255                 1260             


Gly Ile  Tyr Lys Thr Tyr Asn  Ile Thr Lys Ser Val  Ala Val Asn 
    1265                 1270                 1275             


Pro Lys  Glu Ile Ala Ser Lys  Gly Leu Cys 
    1280                 1285             


<210> 5776
<211> 951
<212> PRT
<213> Homo sapiens

<400> 5776
Met Leu Gly Ser Met Ala Arg Lys Lys Pro Arg Asn Thr Ser Arg Leu 
1               5                   10                  15      


Pro Leu Ala Leu Asn Pro Leu Lys Ser Lys Asp Val Leu Ala Val Leu 
            20                  25                  30          


Ala Glu Arg Asn Glu Ala Ile Val Pro Val Gly Ala Trp Val Glu Pro 
        35                  40                  45              


Ala Ser Pro Gly Ser Ser Glu Ile Pro Ala Tyr Thr Ser Ala Tyr Leu 
    50                  55                  60                  


Ile Glu Glu Glu Leu Lys Glu Gln Leu Arg Lys Lys Gln Glu Ala Leu 
65                  70                  75                  80  


Lys His Phe Gln Lys Gln Val Lys Tyr Arg Val Asn Gln Gln Ile Arg 
                85                  90                  95      


Leu Arg Lys Lys Gln Gln Leu Gln Lys Ser Tyr Glu Arg Ala Gln Lys 
            100                 105                 110         


Glu Gly Ser Ile Ala Met Gln Ser Ser Ala Thr His Leu Thr Ser Lys 
        115                 120                 125             


Arg Thr Ser Val Phe Pro Asn Asn Leu Asn Val Ala Ile Gly Ser Ser 
    130                 135                 140                 


Arg Leu Pro Pro Ser Leu Met Pro Gly Asp Gly Ile Glu Asp Glu Glu 
145                 150                 155                 160 


Asn Gln Asn Glu Leu Phe Gln Gln Gln Ala Gln Ala Leu Ser Glu Thr 
                165                 170                 175     


Met Lys Gln Ala Arg His Arg Leu Ala Ser Phe Lys Thr Val Ile Lys 
            180                 185                 190         


Lys Lys Gly Ser Val Phe Pro Asp Asp Gly Arg Lys Ser Phe Leu Thr 
        195                 200                 205             


Arg Glu Glu Val Leu Ser Arg Lys Pro Ala Ser Thr Gly Ile Asn Thr 
    210                 215                 220                 


Gly Ile Arg Gly Glu Leu Pro Ile Lys Val His Gln Gly Leu Leu Ala 
225                 230                 235                 240 


Ala Val Pro Tyr Gln Asn Tyr Met Glu Asn Gln Glu Leu Asp Tyr Glu 
                245                 250                 255     


Glu Pro Asp Tyr Glu Glu Ser Ser Ser Leu Val Thr Asp Glu Lys Gly 
            260                 265                 270         


Lys Glu Asp Leu Phe Gly Arg Gly Gln Gln Asp Gln Gln Ala Ile His 
        275                 280                 285             


Ser Glu Asp Lys Asn Lys Pro Phe Ser Arg Val Gln Lys Val Lys Phe 
    290                 295                 300                 


Lys Asn Pro Leu Phe Val Leu Met Glu Glu Glu Glu Gln Lys Gln Leu 
305                 310                 315                 320 


His Phe Glu Gly Leu Gln Asp Ile Leu Pro Glu Ala Gln Asp Tyr Phe 
                325                 330                 335     


Leu Glu Ala Gln Gly Asp Leu Leu Glu Thr Gln Gly Asp Leu Thr Gly 
            340                 345                 350         


Ile Gln Ser Val Lys Pro Asp Thr Gln Ala Val Glu Met Lys Val Gln 
        355                 360                 365             


Val Thr Glu Pro Glu Gly Gln Ala Ile Glu Pro Glu Gly Gln Pro Ile 
    370                 375                 380                 


Lys Thr Glu Thr Gln Gly Ile Met Leu Lys Ala Gln Ser Ile Glu Leu 
385                 390                 395                 400 


Glu Glu Gly Ser Ile Val Leu Lys Thr Gln Asp Phe Leu Pro Thr Asn 
                405                 410                 415     


Gln Ala Leu Leu Thr Lys Asn Gln Asp Val Leu Leu Lys Asp His Cys 
            420                 425                 430         


Val Leu Pro Lys Asp Gln Ser Ile Leu Leu Lys Tyr Gln Asp Gln Asp 
        435                 440                 445             


Phe Leu Pro Arg Asp Gln His Val Leu His Lys Asp Gln Asp Ile Leu 
    450                 455                 460                 


Pro Lys Tyr Gln Asp Gln Asn Phe Leu Pro Lys Asp Gln Asn Phe Leu 
465                 470                 475                 480 


Ser Arg Asp Gln His Val Leu Pro Lys Asp Gln Asp Ile Leu Pro Lys 
                485                 490                 495     


Tyr Gln Asp Gln Asn Phe Leu Pro Lys Asp Gln Asn Phe Leu Ser Arg 
            500                 505                 510         


Asp Gln His Val Leu Pro Lys Asp Gln Asn Ile Leu Pro Lys Tyr Gln 
        515                 520                 525             


Gly Gln Asp Phe Leu Pro Lys Asp Gln Asp Phe Leu Ser Arg Asp Gln 
    530                 535                 540                 


His Val Leu Pro Lys Asp Trp Asn Ile Leu Pro Lys Cys Gln Asp Gln 
545                 550                 555                 560 


Asp Phe Leu Pro Arg Asp Gln Gly Val Leu Pro Lys Asp Gln Asn Ile 
                565                 570                 575     


Leu Pro Ile Cys Gln Asp Gln Asp Phe Leu Pro Arg Asp Gln Gly Tyr 
            580                 585                 590         


Leu Pro Lys Asp Gln Asn Ile Leu Pro Ile Cys Gln Asp Arg Asp Phe 
        595                 600                 605             


Leu Pro Arg Asp Leu His Val Leu Ser Asn Asp Gln Asn Ile Leu Pro 
    610                 615                 620                 


Lys Cys Gln Asp Gln Asp Phe Leu Pro Lys Tyr Gln Lys Val His Phe 
625                 630                 635                 640 


Lys Glu Pro Tyr Ser Asp Met Thr Asp Glu Lys Gly Arg Glu Asp Phe 
                645                 650                 655     


Ser Leu Ala Asp Tyr Gln Cys Leu Pro Pro Lys Ser Gln Asp Gln Asp 
            660                 665                 670         


Asp Ile Lys Asn Gln Gln Pro Ala Ser Phe Met Arg Glu Glu Arg Val 
        675                 680                 685             


Arg Glu Glu Leu Pro Leu Asp Tyr His Gln Tyr Val Val Pro Lys Ile 
    690                 695                 700                 


Gln Asp Gln Asp Ser Pro Arg Glu Gln Asn Lys His Ile Lys Leu Pro 
705                 710                 715                 720 


Ser Ser Phe Glu Lys Trp Glu Ile Ala Arg Gly Asn Thr Pro Gly Val 
                725                 730                 735     


Pro Leu Ala Tyr Asp Arg Tyr Gln Ser Gly Leu Ser Thr Glu Phe Gln 
            740                 745                 750         


Ala Pro Leu Ala Phe Gln Ser Asp Val Asp Lys Glu Glu Asp Lys Lys 
        755                 760                 765             


Glu Arg Gln Lys Gln Tyr Leu Arg His Arg Arg Leu Phe Met Asp Ile 
    770                 775                 780                 


Glu Arg Glu Gln Val Lys Glu Gln Gln Arg Gln Lys Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Ile Glu Lys Ile Lys Lys Lys Arg Glu Gln Glu Cys Tyr Ala Ala 
                805                 810                 815     


Glu Gln Arg Ile Leu Arg Met Asn Phe His Glu Asp Pro Tyr Ser Gly 
            820                 825                 830         


Glu Lys Leu Ser Glu Ile Leu Ala Gln Leu Gln Leu Gln Glu Ile Lys 
        835                 840                 845             


Gly Thr Arg Glu Lys Gln Gln Arg Glu Lys Glu Tyr Leu Arg Tyr Val 
    850                 855                 860                 


Glu Ala Leu Arg Ala Gln Ile Gln Glu Lys Met Gln Leu Tyr Asn Ile 
865                 870                 875                 880 


Thr Leu Pro Pro Leu Cys Cys Cys Gly Pro Asp Phe Trp Asp Ala His 
                885                 890                 895     


Pro Asp Thr Cys Ala Asn Asn Cys Ile Phe Tyr Lys Asn His Arg Ala 
            900                 905                 910         


Tyr Thr Arg Ala Leu His Ser Phe Ile Asn Ser Cys Asp Val Pro Gly 
        915                 920                 925             


Gly Asn Ser Thr Leu Arg Val Ala Ile His Asn Phe Ala Ser Ala His 
    930                 935                 940                 


Arg Arg Thr Leu Lys Asn Leu 
945                 950     


<210> 5777
<211> 415
<212> PRT
<213> Homo sapiens

<400> 5777
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 
            20                  25                  30          


Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Gly Cys Gln Gly Ser 
        355                 360                 365             


Arg Asp Ala Cys Ser Pro Trp Glu Gln Val Leu Ala Phe Ala Val Ala 
    370                 375                 380                 


Lys Thr Gly Cys Lys Leu Leu Gln Pro Gln Arg Asn Trp Pro Ser Ser 
385                 390                 395                 400 


Arg Gly Pro Pro Trp Arg Ala Ser Glu Gly Glu Arg Thr Ala Gln 
                405                 410                 415 


<210> 5778
<211> 300
<212> PRT
<213> Homo sapiens

<400> 5778
Met Leu Ser Ala Val Ala Arg Gly Tyr Gln Gly Trp Phe His Pro Cys 
1               5                   10                  15      


Ala Arg Leu Ser Val Arg Met Ser Ser Thr Gly Ile Asp Arg Lys Gly 
            20                  25                  30          


Val Leu Ala Asn Arg Val Ala Val Val Thr Gly Ser Thr Ser Gly Ile 
        35                  40                  45              


Gly Phe Ala Ile Ala Arg Arg Leu Ala Arg Asp Gly Ala His Val Val 
    50                  55                  60                  


Ile Ser Ser Arg Lys Gln Gln Asn Val Asp Arg Ala Met Ala Lys Leu 
65                  70                  75                  80  


Gln Gly Glu Gly Leu Ser Val Ala Gly Ile Val Cys His Val Gly Lys 
                85                  90                  95      


Ala Glu Asp Arg Glu Gln Leu Val Ala Lys Ala Leu Glu His Cys Gly 
            100                 105                 110         


Gly Val Asp Phe Leu Val Cys Ser Ala Gly Val Asn Pro Leu Val Gly 
        115                 120                 125             


Ser Thr Leu Gly Thr Ser Glu Gln Ile Trp Asp Lys Ile Leu Ser Val 
    130                 135                 140                 


Asn Val Lys Ser Pro Ala Leu Leu Leu Ser Gln Leu Leu Pro Tyr Met 
145                 150                 155                 160 


Glu Asn Arg Arg Gly Ala Val Ile Leu Val Ser Ser Ile Ala Ala Tyr 
                165                 170                 175     


Asn Pro Val Val Ala Leu Gly Val Tyr Asn Val Ser Lys Thr Ala Leu 
            180                 185                 190         


Leu Gly Leu Thr Arg Thr Leu Ala Leu Glu Leu Ala Pro Lys Asp Ile 
        195                 200                 205             


Arg Val Asn Cys Val Val Pro Gly Ile Ile Lys Thr Asp Phe Ser Lys 
    210                 215                 220                 


Val Val Arg Ile Gly Phe Met Gly Met Ser Leu Ser Gly Arg Thr Ser 
225                 230                 235                 240 


Arg Asn Ile Ile Ser Cys Arg Gly Leu Gly Ser Gln Arg Thr Val Gln 
                245                 250                 255     


Glu Ser Cys Pro Ser Cys Ala Leu Gln Met Pro Ala Thr Ser Thr Gly 
            260                 265                 270         


Arg Thr Leu Arg Trp Gln Ala Thr Pro Leu Gly Ser Glu Arg Ser Gly 
        275                 280                 285             


Gly Gly Cys Val Ala Val Val Pro Gly Pro Gly Ala 
    290                 295                 300 


<210> 5779
<211> 337
<212> PRT
<213> Homo sapiens

<400> 5779
Met Arg Phe Asp Thr Leu Trp Glu Asn Lys Leu Met Gln Ser Arg Ala 
1               5                   10                  15      


Val Asp Gly Phe His Ser Glu Glu Gln Gln Leu Leu Leu Gln Val Gln 
            20                  25                  30          


Gln Gln His Gln Pro Gln Gln Gln Gln His His His His His His His 
        35                  40                  45              


Gln Gln Ala Gln Pro Gln Gln Thr Val Pro Gln Gln Ala Gln Thr Gln 
    50                  55                  60                  


Gln Val Leu Ile Pro Ala Ser Gln Gln Ala Thr Ala Pro Gln Val Ile 
65                  70                  75                  80  


Val Pro Asp Ser Lys Leu Ile Gln His Met Asn Ala Ser Asn Met Ser 
                85                  90                  95      


Ala Ala Ala Thr Ala Ala Thr Leu Ala Leu Pro Ala Gly Val Thr Pro 
            100                 105                 110         


Val Gln Gln Ile Leu Thr Asn Ser Gly Gln Leu Leu Gln Val Val Arg 
        115                 120                 125             


Ala Ala Asn Gly Ala Gln Tyr Ile Phe Gln Pro Gln Gln Ser Val Val 
    130                 135                 140                 


Leu Gln Gln Gln Val Ile Pro Gln Met Gln Pro Gly Gly Val Gln Ala 
145                 150                 155                 160 


Pro Val Ile Gln Gln Val Leu Ala Pro Leu Pro Gly Gly Ile Ser Pro 
                165                 170                 175     


Gln Thr Gly Val Ile Ile Gln Pro Gln Gln Ile Leu Phe Thr Gly Asn 
            180                 185                 190         


Lys Thr Gln Val Ile Pro Thr Thr Val Ala Ala Pro Thr Pro Ala Gln 
        195                 200                 205             


Ala Gln Ile Thr Ala Thr Gly Gln Gln Gln Pro Gln Ala Gln Pro Ala 
    210                 215                 220                 


Gln Thr Gln Ala Pro Leu Val Leu Gln Val Asp Gly Thr Gly Asp Thr 
225                 230                 235                 240 


Ser Ser Glu Glu Asp Glu Asp Glu Glu Glu Asp Tyr Asp Asp Asp Glu 
                245                 250                 255     


Glu Glu Asp Lys Glu Lys Asp Gly Ala Glu Asp Gly Gln Val Glu Glu 
            260                 265                 270         


Glu Pro Leu Asn Ser Glu Asp Asp Val Ser Asp Glu Glu Gly Gln Glu 
        275                 280                 285             


Leu Phe Asp Thr Glu Asn Val Val Val Cys Gln Tyr Asp Lys Ile His 
    290                 295                 300                 


Arg Ser Lys Asn Lys Trp Lys Phe His Leu Lys Asp Gly Ile Met Asn 
305                 310                 315                 320 


Leu Asn Gly Arg Asp Tyr Ile Phe Ser Lys Ala Ile Gly Asp Ala Glu 
                325                 330                 335     


Trp 
    


<210> 5780
<211> 93
<212> PRT
<213> Homo sapiens

<400> 5780
Met Ala Gln Ser Gly Gly Glu Ala Arg Pro Gly Pro Lys Thr Ala Val 
1               5                   10                  15      


Gln Ile Arg Val Ala Ile Gln Glu Ala Glu Asp Val Asp Glu Leu Glu 
            20                  25                  30          


Asp Glu Glu Glu Gly Ala Glu Thr Arg Gly Ala Gly Asp Pro Ala Arg 
        35                  40                  45              


Tyr Leu Ser Pro Gly Trp Gly Ser Ala Ser Glu Glu Glu Pro Ser Arg 
    50                  55                  60                  


Gly His Arg Asn Arg Ser Ser Val Asn Ser Arg Thr Met Leu Ala Ser 
65                  70                  75                  80  


Phe Ile Val Ser Ser Ala Pro Ser Thr Ala Pro Ser Thr 
                85                  90              


<210> 5781
<211> 84
<212> PRT
<213> Homo sapiens

<400> 5781
Met Lys Val Lys Ile Lys Cys Trp Asn Gly Val Ala Thr Trp Leu Trp 
1               5                   10                  15      


Val Ala Asn Asp Glu Asn Cys Gly Ile Cys Arg Met Ala Phe Asn Gly 
            20                  25                  30          


Cys Cys Pro Asp Cys Lys Val Pro Gly Asp Asp Cys Pro Leu Val Trp 
        35                  40                  45              


Gly Gln Cys Ser His Cys Phe His Met His Cys Ile Leu Lys Trp Leu 
    50                  55                  60                  


His Ala Gln Gln Val Gln Gln His Cys Pro Met Cys Arg Gln Glu Trp 
65                  70                  75                  80  


Lys Phe Lys Glu 
                


<210> 5782
<211> 203
<212> PRT
<213> Homo sapiens

<400> 5782
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Ile Arg Phe Thr Lys 
                165                 170                 175     


Met Lys Leu Ser Arg Ser Ser Thr Tyr Glu Asn Arg Tyr Leu Cys Cys 
            180                 185                 190         


Asn Leu His Leu Lys Asp Glu Ser Asn Tyr Ser 
        195                 200             


<210> 5783
<211> 597
<212> PRT
<213> Homo sapiens

<400> 5783
Met Pro Ser Pro Gln Leu Leu Val Leu Phe Gly Ser Gln Thr Gly Thr 
1               5                   10                  15      


Ala Gln Asp Val Ser Glu Arg Leu Gly Arg Glu Ala Arg Arg Arg Arg 
            20                  25                  30          


Leu Gly Cys Arg Val Gln Ala Leu Asp Ser Tyr Pro Val Val Asn Leu 
        35                  40                  45              


Ile Asn Glu Pro Leu Val Ile Phe Val Cys Ala Thr Thr Gly Gln Gly 
    50                  55                  60                  


Asp Pro Pro Asp Asn Met Lys Asn Phe Trp Arg Phe Ile Phe Arg Lys 
65                  70                  75                  80  


Asn Leu Pro Ser Thr Ala Leu Cys Gln Met Asp Phe Ala Val Leu Gly 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Ala Lys Phe Asn Phe Val Ala Lys Lys Leu 
            100                 105                 110         


His Arg Arg Leu Leu Gln Leu Gly Gly Ser Ala Leu Leu Pro Val Cys 
        115                 120                 125             


Leu Gly Asp Asp Gln His Glu Leu Gly Pro Asp Ala Ala Val Asp Pro 
    130                 135                 140                 


Trp Leu Arg Asp Leu Trp Asp Arg Val Leu Gly Leu Tyr Pro Pro Pro 
145                 150                 155                 160 


Pro Gly Leu Thr Glu Ile Pro Pro Gly Val Pro Leu Pro Ser Lys Phe 
                165                 170                 175     


Thr Leu Leu Phe Leu Gln Glu Ala Pro Ser Thr Gly Ser Glu Gly Gln 
            180                 185                 190         


Arg Val Ala His Pro Gly Ser Gln Glu Pro Pro Ser Glu Ser Lys Pro 
        195                 200                 205             


Phe Leu Ala Pro Met Ile Ser Asn Gln Arg Val Thr Gly Pro Ser His 
    210                 215                 220                 


Phe Gln Asp Val Arg Leu Ile Glu Phe Asp Ile Leu Gly Ser Gly Ile 
225                 230                 235                 240 


Ser Phe Ala Ala Gly Asp Val Val Leu Ile Gln Pro Ser Asn Ser Ala 
                245                 250                 255     


Ala His Val Gln Arg Phe Cys Gln Val Leu Gly Leu Asp Pro Asp Gln 
            260                 265                 270         


Leu Phe Met Leu Gln Pro Arg Glu Pro Asp Val Ser Ser Pro Thr Arg 
        275                 280                 285             


Leu Pro Gln Pro Cys Ser Met Arg His Leu Val Ser His Tyr Leu Asp 
    290                 295                 300                 


Ile Ala Ser Val Pro Arg Arg Ser Phe Phe Glu Leu Leu Ala Cys Leu 
305                 310                 315                 320 


Ser Leu His Glu Leu Glu Arg Glu Lys Leu Leu Glu Phe Ser Ser Ala 
                325                 330                 335     


Gln Gly Gln Glu Glu Leu Phe Glu Tyr Cys Asn Arg Pro Arg Arg Thr 
            340                 345                 350         


Ile Leu Glu Val Leu Cys Asp Phe Pro His Thr Ala Ala Ala Ile Pro 
        355                 360                 365             


Pro Asp Tyr Leu Leu Asp Leu Ile Pro Val Ile Arg Pro Arg Ala Phe 
    370                 375                 380                 


Ser Ile Ala Ser Ser Leu Leu Thr His Pro Ser Arg Leu Gln Ile Leu 
385                 390                 395                 400 


Val Ala Val Val Gln Phe Gln Thr Arg Leu Lys Glu Pro Arg Arg Gly 
                405                 410                 415     


Leu Cys Ser Ser Trp Leu Ala Ser Leu Asp Pro Gly Gln Gly Pro Val 
            420                 425                 430         


Arg Val Pro Leu Trp Val Arg Pro Gly Ser Leu Ala Phe Pro Glu Thr 
        435                 440                 445             


Pro Asp Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro 
    450                 455                 460                 


Phe Arg Ala Ala Ile Gln Glu Arg Val Ala Gln Gly Gln Thr Gly Asn 
465                 470                 475                 480 


Phe Leu Phe Phe Gly Cys Arg Trp Arg Asp Gln Asp Phe Tyr Trp Glu 
                485                 490                 495     


Ala Glu Trp Gln Glu Leu Glu Lys Arg Asp Cys Leu Thr Leu Ile Pro 
            500                 505                 510         


Ala Phe Ser Arg Glu Gln Glu Gln Lys Val Tyr Val Gln His Arg Leu 
        515                 520                 525             


Arg Glu Leu Gly Ser Leu Val Trp Glu Leu Leu Asp Arg Gln Gly Ala 
    530                 535                 540                 


Tyr Phe Tyr Leu Ala Gly Asn Ala Lys Ser Met Pro Ala Asp Val Ser 
545                 550                 555                 560 


Glu Ala Leu Met Ser Ile Phe Gln Glu Glu Gly Gly Leu Cys Ser Pro 
                565                 570                 575     


Asp Ala Ala Ala Tyr Leu Ala Arg Leu Gln Gln Thr Arg Arg Phe Gln 
            580                 585                 590         


Thr Glu Thr Trp Ala 
        595         


<210> 5784
<211> 619
<212> PRT
<213> Homo sapiens

<400> 5784
Met Asp Asp Gln Gln Ala Leu Asn Ser Ile Met Gln Asp Leu Ala Val 
1               5                   10                  15      


Leu His Lys Ala Ser Arg Pro Ala Leu Ser Leu Gln Glu Thr Arg Lys 
            20                  25                  30          


Ala Lys Ser Ser Ser Pro Lys Lys Gln Asn Asp Val Arg Val Lys Phe 
        35                  40                  45              


Glu His Arg Gly Glu Lys Arg Ile Leu Gln Phe Pro Arg Pro Val Lys 
    50                  55                  60                  


Leu Glu Asp Leu Arg Ser Lys Ala Lys Ile Ala Phe Gly Gln Ser Met 
65                  70                  75                  80  


Asp Leu His Tyr Thr Asn Asn Glu Leu Val Ile Pro Leu Thr Thr Gln 
                85                  90                  95      


Asp Asp Leu Asp Lys Ala Val Glu Leu Leu Asp Arg Ser Ile His Met 
            100                 105                 110         


Lys Ser Leu Lys Ile Leu Leu Val Ile Asn Gly Ser Thr Gln Ala Thr 
        115                 120                 125             


Asn Leu Glu Pro Leu Pro Ser Leu Glu Asp Leu Asp Asn Thr Val Phe 
    130                 135                 140                 


Gly Ala Glu Arg Lys Lys Arg Leu Ser Ile Ile Gly Pro Thr Ser Arg 
145                 150                 155                 160 


Asp Arg Ser Ser Pro Pro Pro Gly Tyr Ile Pro Asp Glu Leu His Gln 
                165                 170                 175     


Val Ala Arg Asn Gly Ser Phe Thr Ser Ile Asn Ser Glu Gly Glu Phe 
            180                 185                 190         


Ile Pro Glu Ser Met Asp Gln Met Leu Asp Pro Leu Ser Leu Ser Ser 
        195                 200                 205             


Pro Glu Asn Ser Gly Ser Gly Ser Cys Pro Ser Leu Asp Ser Pro Leu 
    210                 215                 220                 


Asp Gly Glu Ser Tyr Pro Lys Ser Arg Met Pro Arg Ala Gln Ser Tyr 
225                 230                 235                 240 


Pro Asp Asn His Gln Glu Phe Ser Asp Tyr Asp Asn Pro Ile Phe Glu 
                245                 250                 255     


Lys Phe Gly Lys Gly Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Tyr 
            260                 265                 270         


His His Gln Glu Tyr Asn Asp Gly Arg Lys Thr Phe Pro Arg Ala Arg 
        275                 280                 285             


Arg Thr Gln Gly Thr Ser Leu Arg Ser Pro Val Ser Phe Ser Pro Thr 
    290                 295                 300                 


Asp His Ser Leu Ser Thr Ser Ser Gly Ser Ser Ile Phe Thr Pro Glu 
305                 310                 315                 320 


Tyr Asp Asp Ser Arg Ile Arg Arg Arg Gly Ser Asp Ile Asp Asn Pro 
                325                 330                 335     


Thr Leu Thr Val Met Asp Ile Ser Pro Pro Ser Arg Ser Pro Arg Ala 
            340                 345                 350         


Pro Thr Asn Trp Arg Leu Gly Lys Leu Leu Gly Gln Gly Ala Phe Gly 
        355                 360                 365             


Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr Gly Arg Glu Leu Ala Val 
    370                 375                 380                 


Lys Gln Val Gln Phe Asp Pro Asp Ser Pro Glu Thr Ser Lys Glu Val 
385                 390                 395                 400 


Asn Ala Leu Glu Cys Glu Ile Gln Leu Leu Lys Asn Leu Leu His Glu 
                405                 410                 415     


Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg Asp Pro Gln Glu Lys Thr 
            420                 425                 430         


Leu Ser Ile Phe Met Glu Tyr Met Pro Gly Gly Ser Ile Lys Asp Gln 
        435                 440                 445             


Leu Lys Ala Tyr Gly Ala Leu Thr Glu Asn Val Thr Arg Lys Tyr Thr 
    450                 455                 460                 


Arg Gln Ile Leu Glu Gly Val His Tyr Leu His Ser Asn Met Ile Val 
465                 470                 475                 480 


His Arg Asp Ile Lys Gly Ala Asn Ile Leu Arg Asp Ser Thr Gly Asn 
                485                 490                 495     


Val Lys Leu Gly Asp Phe Gly Ala Ser Lys Arg Leu Gln Thr Ile Cys 
            500                 505                 510         


Leu Ser Gly Thr Gly Met Lys Ser Val Thr Gly Thr Pro Tyr Trp Met 
        515                 520                 525             


Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr Gly Arg Lys Ala Asp Ile 
    530                 535                 540                 


Trp Ser Val Ala Cys Thr Val Val Glu Met Leu Thr Glu Lys Pro Pro 
545                 550                 555                 560 


Trp Ala Glu Phe Glu Ala Met Ala Ala Ile Phe Lys Ile Ala Thr Gln 
                565                 570                 575     


Pro Thr Asn Pro Lys Leu Pro Pro His Val Ser Asp Tyr Thr Arg Asp 
            580                 585                 590         


Phe Leu Lys Arg Ile Phe Val Glu Ala Lys Leu Arg Pro Ser Ala Asp 
        595                 600                 605             


Glu Leu Leu Arg His Met Phe Val His Tyr His 
    610                 615                 


<210> 5785
<211> 275
<212> PRT
<213> Homo sapiens

<400> 5785
Met Ser Thr Ile Gly Ser Phe Glu Gly Phe Gln Ala Val Ser Leu Lys 
1               5                   10                  15      


Gln Glu Gly Asp Asp Gln Pro Ser Glu Thr Asp His Leu Ser Met Glu 
            20                  25                  30          


Glu Glu Asp Pro Met Pro Arg Gln Ile Ser Arg Gln Ser Ser Val Thr 
        35                  40                  45              


Glu Ser Thr Leu Tyr Pro Asn Pro Tyr His Gln Pro Tyr Ile Ser Arg 
    50                  55                  60                  


Lys Tyr Phe Ala Thr Arg Pro Gly Ala Ile Glu Thr Ala Met Glu Asp 
65                  70                  75                  80  


Leu Lys Gly His Val Ala Glu Thr Ser Gly Glu Thr Ile Gln Gly Phe 
                85                  90                  95      


Trp Leu Leu Thr Lys Ile Asp His Trp Asn Asn Glu Lys Glu Arg Ile 
            100                 105                 110         


Leu Leu Val Thr Asp Lys Thr Leu Leu Ile Cys Lys Tyr Asp Phe Ile 
        115                 120                 125             


Met Leu Ser Cys Val Gln Leu Gln Arg Ile Pro Leu Ser Ala Val Tyr 
    130                 135                 140                 


Arg Ile Cys Leu Gly Lys Phe Thr Phe Pro Gly Met Ser Leu Asp Lys 
145                 150                 155                 160 


Arg Gln Gly Glu Gly Leu Arg Ile Tyr Trp Gly Ser Pro Glu Glu Gln 
                165                 170                 175     


Ser Leu Leu Ser Arg Trp Asn Pro Trp Ser Thr Glu Val Pro Tyr Ala 
            180                 185                 190         


Thr Phe Thr Glu His Pro Met Lys Tyr Thr Ser Glu Lys Phe Leu Glu 
        195                 200                 205             


Ile Cys Lys Leu Ser Gly Phe Met Ser Lys Leu Val Pro Ala Ile Gln 
    210                 215                 220                 


Asn Ala His Lys Asn Ser Thr Gly Ser Gly Arg Gly Lys Lys Leu Met 
225                 230                 235                 240 


Val Leu Thr Glu Pro Ile Leu Ile Glu Thr Tyr Thr Gly Leu Met Ser 
                245                 250                 255     


Phe Ile Gly Asn Arg Asn Lys Leu Gly Tyr Ser Leu Ala Arg Gly Ser 
            260                 265                 270         


Ile Gly Phe 
        275 


<210> 5786
<211> 542
<212> PRT
<213> Homo sapiens

<400> 5786
Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Pro Gly Ser Arg Glu Pro 
1               5                   10                  15      


Gln Asp Arg Pro Glu Cys Gly Ala Gly His Pro Gly Pro Arg Tyr Tyr 
            20                  25                  30          


Arg His Pro Glu Arg Trp Leu Leu Arg Pro Glu Ala Phe Leu Gly Pro 
        35                  40                  45              


Leu Arg Thr Arg Ala Pro Ser Ala Glu Asp Ser Gln Arg Glu Arg Pro 
    50                  55                  60                  


Ala Ala Arg Ser Gly Pro Ala Met Ser Arg Arg Val Val Arg Gln Ser 
65                  70                  75                  80  


Lys Phe Arg His Val Phe Gly Gln Ala Ala Lys Ala Asp Gln Ala Tyr 
                85                  90                  95      


Glu Asp Ile Arg Val Ser Lys Val Thr Trp Asp Ser Ser Phe Cys Ala 
            100                 105                 110         


Val Asn Pro Lys Phe Leu Ala Ile Ile Val Glu Ala Gly Gly Gly Gly 
        115                 120                 125             


Ala Phe Ile Val Leu Pro Leu Ala Lys Thr Gly Arg Val Asp Lys Asn 
    130                 135                 140                 


Tyr Pro Leu Val Thr Gly His Thr Ala Pro Val Leu Asp Ile Asp Trp 
145                 150                 155                 160 


Cys Pro His Asn Asp Asn Val Ile Ala Ser Ala Ser Asp Asp Thr Thr 
                165                 170                 175     


Ile Met Val Trp Gln Ile Pro Asp Tyr Thr Pro Met Arg Asn Ile Thr 
            180                 185                 190         


Glu Pro Ile Ile Thr Leu Glu Gly His Ser Lys Arg Val Gly Ile Leu 
        195                 200                 205             


Ser Trp His Pro Thr Ala Arg Asn Val Leu Leu Ser Ala Gly Gly Asp 
    210                 215                 220                 


Asn Val Ile Ile Ile Trp Asn Val Gly Thr Gly Glu Val Leu Leu Ser 
225                 230                 235                 240 


Leu Asp Asp Met His Pro Asp Val Ile His Ser Val Cys Trp Asn Ser 
                245                 250                 255     


Asn Gly Ser Leu Leu Ala Thr Thr Cys Lys Asp Lys Thr Leu Arg Ile 
            260                 265                 270         


Ile Asp Pro Arg Lys Gly Gln Val Val Ala Glu Arg Phe Ala Ala His 
        275                 280                 285             


Glu Gly Met Arg Pro Met Arg Ala Val Phe Thr Arg Gln Gly His Ile 
    290                 295                 300                 


Phe Thr Thr Gly Phe Thr Arg Met Ser Gln Arg Glu Leu Gly Leu Trp 
305                 310                 315                 320 


Asp Pro Asn Asn Phe Glu Glu Pro Val Ala Leu Gln Glu Met Asp Thr 
                325                 330                 335     


Ser Asn Gly Val Leu Leu Pro Phe Tyr Asp Pro Asp Ser Ser Ile Val 
            340                 345                 350         


Tyr Leu Cys Gly Lys Gly Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr 
        355                 360                 365             


Asp Glu Pro Pro Phe Val His Tyr Leu Asn Thr Phe Ser Ser Lys Glu 
    370                 375                 380                 


Pro Gln Arg Gly Met Gly Phe Met Pro Lys Arg Gly Leu Asp Val Ser 
385                 390                 395                 400 


Lys Cys Glu Ile Ala Arg Phe Tyr Lys Leu His Glu Arg Lys Cys Glu 
                405                 410                 415     


Pro Ile Ile Met Thr Val Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp 
            420                 425                 430         


Leu Tyr Pro Asp Thr Pro Gly Pro Glu Pro Ala Leu Glu Ala Asp Glu 
        435                 440                 445             


Trp Leu Ser Gly Gln Asp Ala Glu Pro Val Leu Ile Ser Leu Arg Asp 
    450                 455                 460                 


Gly Tyr Val Pro Pro Lys His Arg Glu Leu Arg Val Thr Lys Arg Asn 
465                 470                 475                 480 


Ile Leu Asp Val Arg Pro Pro Ser Gly Pro Arg Arg Ser Gln Ser Ala 
                485                 490                 495     


Ser Asp Ala Pro Leu Ser Gln His Thr Leu Glu Thr Leu Leu Glu Glu 
            500                 505                 510         


Ile Lys Ala Leu Arg Glu Arg Val Gln Ala Gln Glu Gln Arg Ile Thr 
        515                 520                 525             


Ala Leu Glu Asn Met Leu Cys Glu Leu Val Asp Gly Thr Asp 
    530                 535                 540         


<210> 5787
<211> 849
<212> PRT
<213> Homo sapiens

<400> 5787
Met Ser Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Thr Tyr Val 
            20                  25                  30          


Glu Glu Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys 
                85                  90                  95      


Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Glu Val Thr Gln Asp 
            100                 105                 110         


Leu Ile Asp Glu Ser Glu Glu Glu Arg Phe Glu Glu Met Pro Glu Thr 
        115                 120                 125             


Ser His Leu Ile Asp Leu Pro Thr Cys Glu Leu Asn Lys Leu Glu Glu 
    130                 135                 140                 


Ile Ala Asp Leu Val Thr Ser Val Leu Ser Ser Pro Ile Arg Arg Glu 
145                 150                 155                 160 


Lys Leu Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu 
                165                 170                 175     


Gln Leu Phe Gln Ala Cys Glu Asn Leu Glu Asn Thr Glu Gly Leu His 
            180                 185                 190         


His Leu Tyr Glu Ile Ile Arg Gly Ile Leu Phe Leu Asn Lys Ala Thr 
        195                 200                 205             


Leu Phe Glu Val Met Phe Ser Asp Glu Cys Ile Met Asp Val Val Gly 
    210                 215                 220                 


Cys Leu Glu Tyr Asp Pro Ala Leu Ala Gln Pro Lys Arg His Arg Glu 
225                 230                 235                 240 


Phe Leu Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Thr Asp 
                245                 250                 255     


Ser Glu Leu Arg Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile 
            260                 265                 270         


Gln Asp Ile Ile Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Phe Leu 
        275                 280                 285             


Ser Thr Leu Thr Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Ser 
    290                 295                 300                 


Met Leu Gln Glu Asp Glu Lys Phe Leu Ser Glu Val Phe Ala Gln Leu 
305                 310                 315                 320 


Thr Asp Glu Ala Thr Asp Asp Asp Lys Arg Arg Glu Leu Val Asn Phe 
                325                 330                 335     


Phe Lys Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg 
            340                 345                 350         


Asp Ala Phe Phe Lys Thr Leu Ala Lys Leu Gly Ile Leu Pro Ala Leu 
        355                 360                 365             


Glu Ile Val Met Gly Met Asp Asp Leu Gln Val Arg Ser Ala Ala Thr 
    370                 375                 380                 


Asp Ile Phe Ser Tyr Leu Val Glu Phe Ser Pro Ser Met Val Arg Glu 
385                 390                 395                 400 


Phe Val Met Gln Glu Ala Gln Gln Ser Asp Asp Asp Ile Leu Leu Ile 
                405                 410                 415     


Asn Val Val Ile Glu Gln Met Ile Cys Asp Thr Asp Pro Glu Leu Gly 
            420                 425                 430         


Gly Ala Val Gln Leu Met Gly Leu Leu Arg Thr Leu Ile Asp Pro Glu 
        435                 440                 445             


Asn Met Leu Ala Thr Thr Asn Lys Thr Glu Lys Ser Glu Phe Leu Asn 
    450                 455                 460                 


Phe Phe Tyr Asn His Cys Met His Val Leu Thr Ala Pro Leu Leu Thr 
465                 470                 475                 480 


Asn Thr Ser Glu Asp Lys Cys Glu Lys Asp Phe Phe Leu Lys His Tyr 
                485                 490                 495     


Arg Tyr Ser Trp Ser Phe Ile Cys Thr Pro Ser His Ser His Ser His 
            500                 505                 510         


Ser Thr Pro Ser Ser Ser Ile Ser Gln Asp Asn Ile Val Gly Ser Asn 
        515                 520                 525             


Lys Asn Asn Thr Ile Cys Pro Asp Asn Tyr Gln Thr Ala Gln Leu Leu 
    530                 535                 540                 


Ala Leu Ile Leu Glu Leu Leu Thr Phe Cys Val Glu His His Thr Tyr 
545                 550                 555                 560 


His Ile Lys Asn Tyr Ile Met Asn Lys Asp Leu Leu Arg Arg Val Leu 
                565                 570                 575     


Val Leu Met Asn Ser Lys His Thr Phe Leu Ala Leu Cys Ala Leu Arg 
            580                 585                 590         


Phe Met Arg Arg Ile Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr 
        595                 600                 605             


Ile Thr Lys Gly Asn Leu Phe Glu Pro Val Ile Asn Ala Leu Leu Asp 
    610                 615                 620                 


Asn Gly Thr Arg Tyr Asn Leu Leu Asn Ser Ala Val Ile Glu Leu Phe 
625                 630                 635                 640 


Glu Phe Ile Arg Val Glu Asp Ile Lys Ser Leu Thr Ala His Ile Val 
                645                 650                 655     


Glu Asn Phe Tyr Lys Ala Leu Glu Ser Ile Glu Tyr Val Gln Thr Phe 
            660                 665                 670         


Lys Gly Leu Lys Thr Lys Tyr Glu Gln Glu Lys Asp Arg Gln Asn Gln 
        675                 680                 685             


Lys Leu Asn Ser Val Pro Ser Ile Leu Arg Ser Asn Arg Phe Arg Arg 
    690                 695                 700                 


Asp Ala Lys Ala Leu Glu Glu Asp Glu Glu Met Trp Phe Asn Glu Asp 
705                 710                 715                 720 


Glu Glu Glu Glu Gly Lys Ala Val Val Ala Pro Val Glu Lys Pro Lys 
                725                 730                 735     


Pro Glu Asp Asp Phe Pro Asp Asn Tyr Glu Lys Phe Met Glu Thr Lys 
            740                 745                 750         


Lys Ala Lys Glu Ser Glu Asp Lys Glu Asn Leu Pro Lys Arg Thr Ser 
        755                 760                 765             


Pro Gly Gly Phe Lys Phe Thr Phe Ser His Ser Ala Ser Ala Ala Asn 
    770                 775                 780                 


Gly Thr Asn Ser Lys Ser Val Val Ala Gln Ile Pro Pro Ala Thr Ser 
785                 790                 795                 800 


Asn Gly Ser Ser Ser Lys Thr Thr Asn Leu Pro Thr Ser Val Thr Ala 
                805                 810                 815     


Thr Lys Gly Ser Leu Val Gly Leu Val Asp Tyr Pro Asp Asp Glu Glu 
            820                 825                 830         


Glu Asp Glu Glu Glu Glu Ser Ser Pro Arg Lys Arg Pro Arg Leu Gly 
        835                 840                 845             


Ser 
    


<210> 5788
<211> 222
<212> PRT
<213> Homo sapiens

<400> 5788
Met Gly Asp Ile Pro Ala Val Gly Leu Ser Ser Trp Lys Ala Ser Pro 
1               5                   10                  15      


Gly Lys Val Thr Glu Ala Val Lys Glu Ala Ile Asp Ala Gly Tyr Arg 
            20                  25                  30          


His Phe Asp Cys Ala Tyr Phe Tyr His Asn Glu Arg Glu Val Gly Ala 
        35                  40                  45              


Gly Ile Arg Cys Lys Ile Lys Glu Gly Ala Val Arg Arg Glu Asp Leu 
    50                  55                  60                  


Phe Ile Ala Thr Lys Leu Trp Cys Thr Cys His Lys Lys Ser Leu Val 
65                  70                  75                  80  


Glu Thr Ala Cys Arg Lys Ser Leu Lys Ala Leu Lys Leu Asn Tyr Leu 
                85                  90                  95      


Asp Leu Tyr Leu Ile His Trp Pro Met Gly Phe Lys Pro Pro His Pro 
            100                 105                 110         


Glu Trp Ile Met Ser Cys Ser Glu Leu Ser Phe Cys Leu Ser His Pro 
        115                 120                 125             


Arg Val Gln Asp Leu Pro Leu Asp Glu Ser Asn Met Val Ile Pro Ser 
    130                 135                 140                 


Asp Thr Asp Phe Leu Asp Thr Trp Glu Ile Leu Ile Arg Phe Gln Ile 
145                 150                 155                 160 


Gln Arg Asn Val Ile Val Ile Pro Gly Ser Ile Thr Pro Ser His Ile 
                165                 170                 175     


Lys Glu Asn Ile Gln Val Phe Asp Phe Glu Leu Thr Gln His Asp Met 
            180                 185                 190         


Asp Asn Ile Leu Ser Leu Asn Arg Asn Leu Arg Leu Ala Met Phe Pro 
        195                 200                 205             


Ile Thr Lys Asn His Lys Asp Tyr Pro Phe His Ile Glu Tyr 
    210                 215                 220         


<210> 5789
<211> 359
<212> PRT
<213> Homo sapiens

<400> 5789
Met Pro Asn Pro Ser Ser Thr Ser Ser Pro Tyr Pro Leu Pro Glu Glu 
1               5                   10                  15      


Ile Arg Asn Leu Leu Ala Asp Val Glu Thr Phe Val Ala Asp Ile Leu 
            20                  25                  30          


Lys Gly Glu Asn Leu Ser Lys Lys Ala Lys Glu Lys Arg Glu Ser Leu 
        35                  40                  45              


Ile Lys Lys Ile Lys Asp Val Lys Ser Ile Tyr Leu Gln Glu Phe Gln 
    50                  55                  60                  


Asp Lys Gly Asp Ala Glu Asp Gly Glu Glu Tyr Asp Asp Pro Phe Ala 
65                  70                  75                  80  


Gly Pro Pro Asp Thr Ile Ser Leu Ala Ser Glu Arg Tyr Asp Lys Asp 
                85                  90                  95      


Asp Glu Ala Pro Ser Asp Gly Ala Gln Phe Pro Pro Ile Ala Ala Gln 
            100                 105                 110         


Asp Leu Pro Phe Val Leu Lys Ala Gly Tyr Leu Glu Lys Arg Arg Lys 
        115                 120                 125             


Asp His Ser Phe Leu Gly Phe Glu Trp Gln Lys Arg Trp Cys Ala Leu 
    130                 135                 140                 


Ser Lys Thr Val Phe Tyr Tyr Tyr Gly Ser Asp Lys Asp Lys Gln Gln 
145                 150                 155                 160 


Lys Gly Glu Phe Ala Ile Asp Gly Tyr Ser Val Arg Met Asn Asn Thr 
                165                 170                 175     


Leu Arg Lys Asp Gly Lys Lys Asp Cys Cys Phe Glu Ile Ser Ala Pro 
            180                 185                 190         


Asp Lys Arg Ile Tyr Gln Phe Thr Ala Ala Ser Pro Lys Asp Ala Glu 
        195                 200                 205             


Glu Trp Val Gln Gln Leu Lys Phe Val Leu Gln Asp Met Glu Ser Asp 
    210                 215                 220                 


Ile Ile Pro Glu Asp Tyr Asp Glu Arg Gly Glu Leu Tyr Asp Asp Val 
225                 230                 235                 240 


Asp His Pro Leu Pro Ile Ser Asn Pro Leu Thr Ser Ser Gln Pro Ile 
                245                 250                 255     


Asp Asp Glu Ile Tyr Glu Glu Leu Pro Glu Glu Glu Glu Asp Ser Ala 
            260                 265                 270         


Pro Val Lys Val Glu Glu Gln Arg Lys Met Ser Gln Asp Ser Val His 
        275                 280                 285             


His Thr Ser Gly Asp Lys Ser Thr Asp Tyr Ala Asn Phe Tyr Gln Gly 
    290                 295                 300                 


Leu Trp Asp Cys Thr Gly Ala Phe Ser Asp Glu Leu Ser Phe Lys Arg 
305                 310                 315                 320 


Gly Asp Val Ile Tyr Ile Leu Ser Lys Glu Tyr Asn Arg Tyr Gly Trp 
                325                 330                 335     


Trp Val Gly Glu Met Lys Gly Ala Ile Gly Leu Val Pro Lys Ala Tyr 
            340                 345                 350         


Ile Met Glu Met Tyr Asp Ile 
        355                 


<210> 5790
<211> 408
<212> PRT
<213> Homo sapiens

<400> 5790
Met Lys Cys Glu His Cys Thr Arg Lys Glu Cys Ser Lys Lys Thr Lys 
1               5                   10                  15      


Thr Asp Asp Gln Glu Asn Val Ser Ala Asp Ala Pro Ser Pro Ala Gln 
            20                  25                  30          


Glu Asn Gly Glu Lys Cys Asp Thr Ser Lys His Lys Val Leu Val Val 
        35                  40                  45              


Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala Ala Lys Phe Asn Leu 
    50                  55                  60                  


Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly Phe Leu Lys Ser Leu 
65                  70                  75                  80  


Gly Val His Tyr Val Phe Asp Thr Thr Ile Ala Ala Asp Phe Ser Ile 
                85                  90                  95      


Leu Glu Ser Gln Lys Glu Phe Val Arg Arg Tyr Arg Gln His Ser Glu 
            100                 105                 110         


Glu Glu Arg Thr Leu Pro Met Leu Thr Ser Ala Cys Pro Gly Trp Val 
        115                 120                 125             


Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile Thr Ala His Leu Cys 
    130                 135                 140                 


Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys Ile Phe His Val Ile 
                165                 170                 175     


Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala Leu Gln Glu Ser Leu 
            180                 185                 190         


Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp Cys Val Leu Thr Ser 
        195                 200                 205             


Gly Glu Ile Ala Gln Ile Met Glu Gln Gly Asp Leu Ser Val Arg Asp 
    210                 215                 220                 


Ala Ala Val Asp Thr Leu Phe Gly Asp Leu Lys Glu Asp Lys Val Thr 
225                 230                 235                 240 


Arg His Asp Gly Ala Ser Ser Asp Gly His Leu Ala His Ile Phe Arg 
                245                 250                 255     


His Ala Ala Lys Glu Leu Phe Asn Glu Asp Val Glu Glu Val Thr Tyr 
            260                 265                 270         


Arg Ala Leu Arg Asn Lys Asp Phe Gln Glu Val Thr Leu Glu Lys Asn 
        275                 280                 285             


Gly Glu Val Val Leu Arg Phe Ala Ala Ala Tyr Gly Phe Arg Asn Ile 
    290                 295                 300                 


Gln Asn Met Ile Leu Lys Leu Lys Lys Gly Lys Phe Pro Phe His Phe 
305                 310                 315                 320 


Val Glu Val Leu Ala Cys Ala Gly Gly Cys Leu Asn Gly Arg Gly Gln 
                325                 330                 335     


Ala Gln Thr Pro Asp Gly His Ala Asp Lys Ala Leu Leu Arg Gln Met 
            340                 345                 350         


Glu Gly Ile Tyr Ala Asp Ile Pro Val Arg Arg Pro Glu Ser Ser Ala 
        355                 360                 365             


His Val Gln Glu Leu Tyr Gln Glu Trp Leu Glu Gly Ile Asn Ser Pro 
    370                 375                 380                 


Lys Ala Arg Glu Val Leu His Thr Thr Tyr Gln Ser Gln Glu Arg Gly 
385                 390                 395                 400 


Thr His Ser Leu Asp Ile Lys Trp 
                405             


<210> 5791
<211> 367
<212> PRT
<213> Homo sapiens

<400> 5791
Met Ala Leu Asn Val Ala Pro Val Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Gln Phe Gln Arg Gly Thr Cys Ser Arg Ser Asp Glu 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Pro Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Thr His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Thr Ala Ala Ala Met 
                85                  90                  95      


Leu Ala Gln Gln Met Gln Phe Met Phe Pro Gly Thr Pro Leu His Pro 
            100                 105                 110         


Val Pro Thr Phe Pro Val Gly Pro Ala Ile Gly Thr Asn Thr Ala Ile 
        115                 120                 125             


Ser Phe Ala Pro Tyr Leu Ala Pro Val Thr Pro Gly Val Gly Leu Val 
    130                 135                 140                 


Pro Thr Glu Ile Leu Pro Thr Thr Pro Val Ile Val Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Val Thr Val Pro Gly Ser Thr Ala Thr Gln Lys Leu Leu Arg Thr 
                165                 170                 175     


Asp Lys Leu Glu Val Cys Arg Glu Phe Gln Arg Gly Asn Cys Ala Arg 
            180                 185                 190         


Gly Glu Thr Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile 
        195                 200                 205             


Asp Thr Ser Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly 
    210                 215                 220                 


Arg Cys Met Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu 
225                 230                 235                 240 


Gln Ala Lys Ile Lys Ala Ala Gln His Gln Ala Asn Gln Ala Ala Val 
                245                 250                 255     


Ala Ala Gln Ala Ala Ala Ala Ala Ala Thr Val Met Ala Phe Pro Pro 
            260                 265                 270         


Gly Ala Leu His Pro Leu Pro Lys Arg Gln Ala Leu Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ser Ala Val Phe Asn Pro Ser Val Leu His Tyr Gln Gln Ala 
    290                 295                 300                 


Leu Thr Ser Ala Gln Leu Gln Gln His Ala Ala Phe Ile Pro Thr Gly 
305                 310                 315                 320 


Ser Val Leu Cys Met Thr Pro Ala Thr Ser Ile Val Pro Met Met His 
                325                 330                 335     


Ser Ala Thr Ser Ala Thr Val Ser Ala Ala Thr Thr Pro Ala Thr Ser 
            340                 345                 350         


Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln Ile Ile Leu Lys 
        355                 360                 365         


<210> 5792
<211> 1302
<212> PRT
<213> Homo sapiens

<400> 5792
Met Ala Leu Arg Pro Gly Ala Gly Ser Gly Gly Gly Gly Ala Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ser Ala Gly Gly Gly Gly Phe Met Phe Pro Val Ala 
            20                  25                  30          


Gly Gly Ile Arg Pro Pro Gln Ala Gly Leu Met Pro Met Gln Gln Gln 
        35                  40                  45              


Gly Phe Pro Met Val Ser Val Met Gln Pro Asn Met Gln Gly Ile Met 
    50                  55                  60                  


Gly Met Asn Tyr Ser Ser Gln Met Ser Gln Gly Pro Ile Ala Met Gln 
65                  70                  75                  80  


Ala Gly Ile Pro Met Gly Pro Met Pro Ala Ala Gly Met Pro Tyr Leu 
                85                  90                  95      


Gly Gln Ala Pro Phe Leu Gly Met Arg Pro Pro Gly Pro Gln Tyr Thr 
            100                 105                 110         


Pro Asp Met Gln Lys Gln Phe Ala Glu Glu Gln Gln Lys Arg Phe Glu 
        115                 120                 125             


Gln Gln Gln Lys Leu Leu Glu Glu Glu Arg Lys Arg Arg Gln Phe Glu 
    130                 135                 140                 


Glu Gln Lys Gln Lys Leu Arg Leu Leu Ser Ser Val Lys Pro Lys Thr 
145                 150                 155                 160 


Gly Glu Lys Ser Arg Asp Asp Ala Leu Glu Ala Ile Lys Gly Asn Leu 
                165                 170                 175     


Asp Gly Phe Ser Arg Asp Ala Lys Met His Pro Thr Pro Ala Ser His 
            180                 185                 190         


Pro Lys Lys Pro Gly Pro Ser Leu Glu Glu Lys Phe Leu Val Ser Cys 
        195                 200                 205             


Asp Ile Ser Thr Ser Gly Gln Glu Gln Ile Lys Leu Asn Thr Ser Glu 
    210                 215                 220                 


Val Gly His Lys Ala Leu Gly Pro Gly Ser Ser Lys Lys Tyr Pro Ser 
225                 230                 235                 240 


Leu Met Ala Ser Asn Gly Val Ala Val Asp Gly Cys Val Ser Gly Thr 
                245                 250                 255     


Thr Thr Ala Glu Ala Glu Asn Thr Ser Asp Gln Asn Leu Ser Ile Glu 
            260                 265                 270         


Glu Ser Gly Val Gly Val Phe Pro Ser Gln Asp Pro Ala Gln Pro Arg 
        275                 280                 285             


Met Pro Pro Trp Ile Tyr Asn Glu Ser Leu Val Pro Asp Ala Tyr Lys 
    290                 295                 300                 


Lys Ile Leu Glu Thr Thr Met Thr Pro Thr Gly Ile Asp Thr Ala Lys 
305                 310                 315                 320 


Leu Tyr Pro Ile Leu Met Ser Ser Gly Leu Pro Arg Glu Thr Leu Gly 
                325                 330                 335     


Gln Ile Trp Ala Leu Ala Asn Arg Thr Thr Pro Gly Lys Leu Thr Lys 
            340                 345                 350         


Glu Glu Leu Tyr Thr Val Leu Ala Met Ile Ala Val Thr Gln Arg Gly 
        355                 360                 365             


Val Pro Ala Met Ser Pro Asp Ala Leu Asn Gln Phe Pro Ala Ala Pro 
    370                 375                 380                 


Ile Pro Thr Leu Ser Gly Phe Ser Met Thr Leu Pro Thr Pro Val Ser 
385                 390                 395                 400 


Gln Pro Thr Val Ile Pro Ser Gly Pro Ala Gly Ser Met Pro Leu Ser 
                405                 410                 415     


Leu Gly Gln Pro Val Met Gly Ile Asn Leu Val Gly Pro Val Gly Gly 
            420                 425                 430         


Ala Ala Ala Gln Ala Ser Ser Gly Phe Ile Pro Thr Tyr Pro Ala Asn 
        435                 440                 445             


Gln Val Val Lys Pro Glu Glu Asp Asp Phe Gln Asp Phe Gln Asp Ala 
    450                 455                 460                 


Ser Lys Ser Gly Ser Leu Asp Asp Ser Phe Ser Asp Phe Gln Glu Leu 
465                 470                 475                 480 


Pro Ala Ser Ser Lys Thr Ser Asn Ser Gln His Gly Asn Ser Ala Pro 
                485                 490                 495     


Ser Leu Leu Met Pro Leu Pro Gly Thr Lys Ala Leu Pro Ser Met Asp 
            500                 505                 510         


Lys Tyr Ala Val Phe Lys Gly Ile Ala Ala Asp Lys Ser Ser Glu Asn 
        515                 520                 525             


Thr Val Pro Pro Gly Asp Pro Gly Asp Lys Tyr Ser Ala Phe Arg Glu 
    530                 535                 540                 


Leu Glu Gln Thr Ala Glu Asn Lys Pro Leu Gly Glu Ser Phe Ala Glu 
545                 550                 555                 560 


Phe Arg Ser Ala Gly Thr Asp Asp Gly Phe Thr Asp Phe Lys Thr Ala 
                565                 570                 575     


Asp Ser Val Ser Pro Leu Glu Pro Pro Thr Lys Asp Lys Thr Phe Pro 
            580                 585                 590         


Pro Ser Phe Pro Ser Gly Thr Ile Gln Gln Lys Gln Gln Thr Gln Val 
        595                 600                 605             


Lys Asn Pro Leu Asn Leu Ala Asp Leu Asp Met Phe Ser Ser Val Asn 
    610                 615                 620                 


Cys Ser Ser Glu Lys Pro Leu Ser Phe Ser Ala Val Phe Ser Thr Ser 
625                 630                 635                 640 


Lys Ser Val Ser Thr Pro Gln Ser Thr Gly Ser Ala Ala Thr Met Thr 
                645                 650                 655     


Ala Leu Ala Ala Thr Lys Thr Ser Ser Leu Ala Asp Asp Phe Gly Glu 
            660                 665                 670         


Phe Ser Leu Phe Gly Glu Tyr Ser Gly Leu Ala Pro Val Gly Glu Gln 
        675                 680                 685             


Asp Asp Phe Ala Asp Phe Met Ala Phe Ser Asn Ser Ser Ile Ser Ser 
    690                 695                 700                 


Glu Gln Lys Pro Asp Asp Lys Tyr Asp Ala Leu Lys Glu Glu Ala Ser 
705                 710                 715                 720 


Pro Val Pro Leu Thr Ser Asn Val Gly Ser Thr Val Lys Gly Gly Gln 
                725                 730                 735     


Asn Ser Thr Ala Ala Ser Thr Lys Tyr Asp Val Phe Arg Gln Leu Ser 
            740                 745                 750         


Leu Glu Gly Ser Gly Leu Gly Val Glu Asp Leu Lys Asp Asn Thr Pro 
        755                 760                 765             


Ser Gly Lys Ser Asp Asp Asp Phe Ala Asp Phe His Ser Ser Lys Phe 
    770                 775                 780                 


Ser Ser Ile Asn Ser Asp Lys Ser Leu Gly Glu Lys Ala Val Ala Phe 
785                 790                 795                 800 


Arg His Thr Lys Glu Asp Ser Ala Ser Val Lys Ser Leu Asp Leu Pro 
                805                 810                 815     


Ser Ile Gly Gly Ser Ser Val Gly Lys Glu Asp Ser Glu Asp Ala Leu 
            820                 825                 830         


Ser Val Gln Phe Asp Met Lys Leu Ala Asp Val Gly Gly Asp Leu Lys 
        835                 840                 845             


His Val Met Ser Asp Ser Ser Leu Asp Leu Pro Thr Val Ser Gly Gln 
    850                 855                 860                 


His Pro Pro Ala Ala Asp Ile Glu Asp Leu Lys Tyr Ala Ala Phe Gly 
865                 870                 875                 880 


Ser Tyr Ser Ser Asn Phe Ala Val Ser Thr Leu Thr Ser Tyr Asp Trp 
                885                 890                 895     


Ser Asp Arg Asp Asp Ala Thr Gln Gly Arg Lys Leu Ser Pro Phe Val 
            900                 905                 910         


Leu Ser Ala Gly Ser Gly Ser Pro Ser Ala Thr Ser Ile Leu Gln Lys 
        915                 920                 925             


Lys Glu Thr Ser Phe Gly Ser Ser Glu Asn Ile Thr Met Thr Ser Leu 
    930                 935                 940                 


Ser Lys Val Thr Thr Phe Val Ser Glu Asp Ala Leu Pro Glu Thr Thr 
945                 950                 955                 960 


Phe Pro Ala Leu Ala Ser Phe Lys Asp Thr Ile Pro Gln Thr Ser Glu 
                965                 970                 975     


Gln Lys Glu Tyr Glu Asn Arg Asp Tyr Lys Asp Phe Thr Lys Gln Asp 
            980                 985                 990         


Leu Pro Thr Ala Glu Arg Ser Gln  Glu Ala Thr Cys Pro  Ser Pro Ala 
        995                 1000                 1005             


Ser Ser  Gly Ala Ser Gln Glu  Thr Pro Asn Glu Cys  Ser Asp Asp 
    1010                 1015                 1020             


Phe Gly  Glu Phe Gln Ser Glu  Lys Pro Lys Ile Ser  Lys Phe Asp 
    1025                 1030                 1035             


Phe Leu  Val Ala Thr Ser Gln  Ser Lys Met Lys Ser  Ser Glu Glu 
    1040                 1045                 1050             


Met Ile  Lys Ser Glu Leu Ala  Thr Phe Asp Leu Ser  Val Gln Gly 
    1055                 1060                 1065             


Ser His  Lys Arg Ser Leu Ser  Leu Gly Asp Lys Glu  Ile Ser Arg 
    1070                 1075                 1080             


Ser Ser  Pro Ser Pro Ala Leu  Glu Gln Pro Phe Arg  Asp Arg Ser 
    1085                 1090                 1095             


Asn Thr  Leu Asn Glu Lys Pro  Ala Leu Pro Val Ile  Arg Asp Lys 
    1100                 1105                 1110             


Tyr Lys  Asp Leu Thr Gly Glu  Val Glu Glu Asn Glu  Arg Tyr Ala 
    1115                 1120                 1125             


Tyr Glu  Trp Gln Arg Cys Leu  Gly Ser Ala Leu Asn  Val Ile Lys 
    1130                 1135                 1140             


Lys Ala  Asn Asp Thr Leu Asn  Gly Ile Ser Ser Ser  Ser Val Cys 
    1145                 1150                 1155             


Thr Glu  Val Ile Gln Ser Ala  Gln Gly Met Glu Tyr  Leu Leu Gly 
    1160                 1165                 1170             


Val Val  Glu Val Tyr Arg Val  Thr Lys Arg Val Glu  Leu Gly Ile 
    1175                 1180                 1185             


Lys Ala  Thr Ala Val Cys Ser  Glu Lys Leu Gln Gln  Leu Leu Lys 
    1190                 1195                 1200             


Asp Ile  Asp Lys Val Trp Asn  Asn Leu Ile Gly Phe  Met Ser Leu 
    1205                 1210                 1215             


Ala Thr  Leu Thr Pro Asp Glu  Asn Ser Leu Asp Phe  Ser Ser Cys 
    1220                 1225                 1230             


Met Leu  Arg Pro Gly Ile Lys  Asn Ala Gln Glu Leu  Ala Cys Gly 
    1235                 1240                 1245             


Val Cys  Leu Leu Asn Val Asp  Ser Arg Ser Arg Ala  Phe Asn Ser 
    1250                 1255                 1260             


Glu Thr  Asp Ser Phe Lys Leu  Ala Tyr Gly Gly His  Gln Tyr His 
    1265                 1270                 1275             


Ala Ser  Cys Ala Asn Phe Trp  Ile Asn Cys Val Glu  Pro Lys Pro 
    1280                 1285                 1290             


Pro Gly  Leu Val Leu Pro Asp  Leu Leu 
    1295                 1300         


<210> 5793
<211> 336
<212> PRT
<213> Homo sapiens

<400> 5793
Met Glu Ser Val Leu Ser Lys Tyr Glu Asp Gln Ile Thr Ile Phe Thr 
1               5                   10                  15      


Asp Tyr Leu Glu Glu Tyr Pro Asp Thr Asp Glu Leu Val Trp Ile Leu 
            20                  25                  30          


Gly Lys Gln His Leu Leu Lys Thr Glu Lys Ser Lys Leu Leu Ser Asp 
        35                  40                  45              


Ile Ser Ala Arg Leu Trp Phe Thr Tyr Arg Arg Lys Phe Ser Pro Ile 
    50                  55                  60                  


Gly Gly Thr Gly Pro Ser Ser Asp Ala Gly Trp Gly Cys Met Leu Arg 
65                  70                  75                  80  


Cys Gly Gln Met Met Leu Ala Gln Ala Leu Ile Cys Arg His Leu Gly 
                85                  90                  95      


Arg Asp Trp Ser Trp Glu Lys Gln Lys Glu Gln Pro Lys Glu Tyr Gln 
            100                 105                 110         


Arg Ile Leu Gln Cys Phe Leu Asp Arg Lys Asp Cys Cys Tyr Ser Ile 
        115                 120                 125             


His Gln Met Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Glu 
    130                 135                 140                 


Trp Phe Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Leu 
145                 150                 155                 160 


Phe Asp Glu Trp Asn Ser Leu Ala Val Tyr Val Ser Met Asp Asn Thr 
                165                 170                 175     


Val Val Ile Glu Asp Ile Lys Lys Met Cys Arg Val Leu Pro Leu Ser 
            180                 185                 190         


Ala Asp Thr Ala Gly Asp Arg Pro Pro Asp Ser Leu Thr Ala Ser Asn 
        195                 200                 205             


Gln Ser Asp Glu Leu Ile Phe Leu Asp Pro His Thr Thr Gln Thr Phe 
    210                 215                 220                 


Val Asp Thr Glu Glu Asn Gly Thr Val Asn Asp Gln Thr Phe His Cys 
225                 230                 235                 240 


Leu Gln Ser Pro Gln Arg Met Asn Ile Leu Asn Leu Asp Pro Ser Val 
                245                 250                 255     


Ala Leu Gly Phe Phe Cys Lys Glu Glu Lys Asp Phe Asp Asn Trp Cys 
            260                 265                 270         


Ser Leu Val Gln Lys Glu Ile Leu Lys Glu Asn Leu Arg Met Phe Glu 
        275                 280                 285             


Leu Val Gln Lys His Pro Ser His Trp Pro Pro Phe Val Pro Pro Ala 
    290                 295                 300                 


Lys Pro Glu Val Thr Thr Thr Gly Ala Glu Phe Ile Asp Ser Thr Glu 
305                 310                 315                 320 


Gln Leu Glu Glu Phe Asp Leu Glu Glu Asp Phe Glu Ile Leu Ser Val 
                325                 330                 335     


<210> 5794
<211> 1005
<212> PRT
<213> Homo sapiens

<400> 5794
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Arg Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu 
    690                 695                 700                 


His Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser 
705                 710                 715                 720 


Leu Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln 
                725                 730                 735     


Gly Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg 
            740                 745                 750         


Cys Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile 
        755                 760                 765             


Ala Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly 
    770                 775                 780                 


Phe Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys 
785                 790                 795                 800 


Arg Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala 
                805                 810                 815     


Cys Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu 
            820                 825                 830         


Leu Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu 
        835                 840                 845             


Cys Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu 
    850                 855                 860                 


Lys Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr 
865                 870                 875                 880 


Leu Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu 
                885                 890                 895     


Leu Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro 
            900                 905                 910         


Thr Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser 
        915                 920                 925             


Ala Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu 
    930                 935                 940                 


Arg Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp 
945                 950                 955                 960 


Leu Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu 
                965                 970                 975     


Trp Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala 
            980                 985                 990         


Ala Leu Arg Val Thr Lys Pro Tyr  Leu Asp Ile Gly Cys  
        995                 1000                 1005 


<210> 5795
<211> 205
<212> PRT
<213> Homo sapiens

<400> 5795
Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Leu Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg 
            20                  25                  30          


Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro 
        35                  40                  45              


Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser 
    50                  55                  60                  


Cys Cys Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys 
65                  70                  75                  80  


Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln 
                85                  90                  95      


Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Ser Ile Ser 
            100                 105                 110         


Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Arg Cys Cys Arg Ser Gln 
        115                 120                 125             


Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys 
    130                 135                 140                 


Cys Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys 
145                 150                 155                 160 


Arg Pro Cys Cys Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly 
                165                 170                 175     


Arg Val Ser Cys His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser 
            180                 185                 190         


Thr Cys Pro Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys 
        195                 200                 205 


<210> 5796
<211> 190
<212> PRT
<213> Homo sapiens

<400> 5796
Met Gln Ser Cys Glu Ser Ser Gly Asp Ser Ala Asp Asp Pro Leu Ser 
1               5                   10                  15      


Arg Gly Leu Arg Arg Arg Gly Gln Pro Arg Val Val Val Ile Gly Ala 
            20                  25                  30          


Gly Leu Ala Gly Leu Ala Ala Ala Lys Ala Leu Leu Glu Gln Gly Phe 
        35                  40                  45              


Thr Asp Val Thr Val Leu Glu Ala Ser Ser His Ile Gly Gly Arg Val 
    50                  55                  60                  


Gln Ser Val Lys Leu Gly His Ala Thr Phe Glu Leu Gly Ala Thr Trp 
65                  70                  75                  80  


Ile His Gly Ser His Gly Asn Pro Ile Tyr His Leu Ala Glu Ala Asn 
                85                  90                  95      


Gly Leu Leu Glu Glu Thr Thr Asp Gly Glu Arg Ser Val Gly Arg Ile 
            100                 105                 110         


Ser Leu Tyr Ser Lys Asn Gly Val Ala Cys Tyr Leu Thr Asn His Gly 
        115                 120                 125             


Arg Arg Ile Pro Lys Asp Val Val Glu Glu Phe Ser Asp Leu Tyr Asn 
    130                 135                 140                 


Glu Pro Met Gln Val Leu Phe Ser Gly Glu Ala Thr His Arg Lys Tyr 
145                 150                 155                 160 


Tyr Ser Thr Thr His Gly Ala Leu Leu Ser Gly Gln Arg Glu Ala Ala 
                165                 170                 175     


Arg Leu Ile Glu Met Tyr Arg Asp Leu Phe Gln Gln Gly Thr 
            180                 185                 190 


<210> 5797
<211> 1314
<212> PRT
<213> Homo sapiens

<400> 5797
Met Ala Leu Arg Pro Gly Ala Gly Ser Gly Gly Gly Gly Ala Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ser Ala Gly Gly Gly Gly Phe Met Phe Pro Val Ala 
            20                  25                  30          


Gly Gly Ile Arg Pro Pro Gln Ala Gly Leu Met Pro Met Gln Gln Gln 
        35                  40                  45              


Gly Phe Pro Met Val Ser Val Met Gln Pro Asn Met Gln Gly Ile Met 
    50                  55                  60                  


Gly Met Asn Tyr Ser Ser Gln Met Ser Gln Gly Pro Ile Ala Met Gln 
65                  70                  75                  80  


Ala Gly Ile Pro Met Gly Pro Met Pro Ala Ala Gly Met Pro Tyr Leu 
                85                  90                  95      


Gly Gln Ala Pro Phe Leu Gly Met Arg Pro Pro Gly Pro Gln Tyr Thr 
            100                 105                 110         


Pro Asp Met Gln Lys Gln Phe Ala Glu Glu Gln Gln Lys Arg Phe Glu 
        115                 120                 125             


Gln Gln Gln Lys Leu Leu Glu Glu Glu Arg Lys Arg Arg Gln Phe Glu 
    130                 135                 140                 


Glu Gln Lys Gln Lys Leu Arg Leu Leu Ser Ser Val Lys Pro Lys Thr 
145                 150                 155                 160 


Gly Glu Lys Ser Arg Asp Asp Ala Leu Glu Ala Ile Lys Gly Asn Leu 
                165                 170                 175     


Asp Gly Phe Ser Arg Asp Ala Lys Met His Pro Thr Pro Ala Ser His 
            180                 185                 190         


Pro Lys Lys Pro Gly Pro Ser Leu Glu Glu Lys Phe Leu Val Ser Cys 
        195                 200                 205             


Asp Ile Ser Thr Ser Gly Gln Glu Gln Ile Lys Leu Asn Thr Ser Glu 
    210                 215                 220                 


Val Gly His Lys Ala Leu Gly Pro Gly Ser Ser Lys Lys Tyr Pro Ser 
225                 230                 235                 240 


Leu Met Ala Ser Asn Gly Val Ala Val Asp Gly Cys Val Ser Gly Thr 
                245                 250                 255     


Thr Thr Ala Glu Ala Glu Asn Thr Ser Asp Gln Asn Leu Ser Ile Glu 
            260                 265                 270         


Glu Ser Gly Val Gly Val Phe Pro Ser Gln Asp Pro Ala Gln Pro Arg 
        275                 280                 285             


Met Pro Pro Trp Ile Tyr Asn Glu Ser Leu Val Pro Asp Ala Tyr Lys 
    290                 295                 300                 


Lys Ile Leu Glu Thr Thr Met Thr Pro Thr Gly Ile Asp Thr Ala Lys 
305                 310                 315                 320 


Leu Tyr Pro Ile Leu Met Ser Ser Gly Leu Pro Arg Glu Thr Leu Gly 
                325                 330                 335     


Gln Ile Trp Ala Leu Ala Asn Arg Thr Thr Pro Gly Lys Leu Thr Lys 
            340                 345                 350         


Glu Glu Leu Tyr Thr Val Leu Ala Met Ile Ala Val Thr Gln Arg Gly 
        355                 360                 365             


Val Pro Ala Met Ser Pro Asp Ala Leu Asn Gln Phe Pro Ala Ala Pro 
    370                 375                 380                 


Ile Pro Thr Leu Ser Gly Phe Ser Met Thr Leu Pro Thr Pro Val Ser 
385                 390                 395                 400 


Gln Pro Thr Val Ile Pro Ser Gly Pro Ala Gly Ser Met Pro Leu Ser 
                405                 410                 415     


Leu Gly Gln Pro Val Met Gly Ile Asn Leu Val Gly Pro Val Gly Gly 
            420                 425                 430         


Ala Ala Ala Gln Ala Ser Ser Gly Phe Ile Pro Thr Tyr Pro Ala Asn 
        435                 440                 445             


Gln Val Val Lys Pro Glu Glu Asp Asp Phe Gln Asp Phe Gln Asp Ala 
    450                 455                 460                 


Ser Lys Ser Gly Ser Leu Asp Asp Ser Phe Ser Asp Phe Gln Glu Leu 
465                 470                 475                 480 


Pro Ala Ser Ser Lys Thr Ser Asn Ser Gln His Gly Asn Ser Ala Pro 
                485                 490                 495     


Ser Leu Leu Met Pro Leu Pro Gly Thr Lys Ala Leu Pro Ser Met Asp 
            500                 505                 510         


Lys Tyr Ala Val Phe Lys Gly Ile Ala Ala Asp Lys Ser Ser Glu Asn 
        515                 520                 525             


Thr Val Pro Pro Gly Asp Pro Gly Asp Lys Tyr Ser Ala Phe Arg Glu 
    530                 535                 540                 


Leu Glu Gln Thr Ala Glu Asn Lys Pro Leu Gly Glu Ser Phe Ala Glu 
545                 550                 555                 560 


Phe Arg Ser Ala Gly Thr Asp Asp Gly Phe Thr Asp Phe Lys Thr Ala 
                565                 570                 575     


Asp Ser Val Ser Pro Leu Glu Pro Pro Thr Lys Asp Lys Thr Phe Pro 
            580                 585                 590         


Pro Ser Phe Pro Ser Gly Thr Ile Gln Gln Lys Gln Gln Thr Gln Val 
        595                 600                 605             


Lys Asn Pro Leu Asn Leu Ala Asp Leu Asp Met Phe Ser Ser Val Asn 
    610                 615                 620                 


Cys Ser Ser Glu Lys Pro Leu Ser Phe Ser Ala Val Phe Ser Thr Ser 
625                 630                 635                 640 


Lys Ser Val Ser Thr Pro Gln Ser Thr Gly Ser Ala Ala Thr Met Thr 
                645                 650                 655     


Ala Leu Ala Ala Thr Lys Thr Ser Ser Leu Ala Asp Asp Phe Gly Glu 
            660                 665                 670         


Phe Ser Leu Phe Gly Glu Tyr Ser Gly Leu Ala Pro Val Gly Glu Gln 
        675                 680                 685             


Asp Asp Phe Ala Asp Phe Met Ala Phe Ser Asn Ser Ser Ile Ser Ser 
    690                 695                 700                 


Glu Gln Lys Pro Asp Asp Lys Tyr Asp Ala Leu Lys Glu Glu Ala Ser 
705                 710                 715                 720 


Pro Val Pro Leu Thr Ser Asn Val Gly Ser Thr Val Lys Gly Gly Gln 
                725                 730                 735     


Asn Ser Thr Ala Ala Ser Thr Lys Tyr Asp Val Phe Arg Gln Leu Ser 
            740                 745                 750         


Leu Glu Gly Ser Gly Leu Gly Val Glu Asp Leu Lys Asp Asn Thr Pro 
        755                 760                 765             


Ser Gly Lys Ser Asp Asp Asp Phe Ala Asp Phe His Ser Ser Lys Phe 
    770                 775                 780                 


Ser Ser Ile Asn Ser Asp Lys Ser Leu Gly Glu Lys Ala Val Ala Phe 
785                 790                 795                 800 


Arg His Thr Lys Glu Asp Ser Ala Ser Val Lys Ser Leu Asp Leu Pro 
                805                 810                 815     


Ser Ile Gly Gly Ser Ser Val Gly Lys Glu Asp Ser Glu Asp Ala Leu 
            820                 825                 830         


Ser Val Gln Phe Asp Met Lys Leu Ala Asp Val Gly Gly Asp Leu Lys 
        835                 840                 845             


His Val Met Ser Asp Ser Ser Leu Asp Leu Pro Thr Val Ser Gly Gln 
    850                 855                 860                 


His Pro Pro Ala Ala Asp Ile Glu Asp Leu Lys Tyr Ala Ala Phe Gly 
865                 870                 875                 880 


Ser Tyr Ser Ser Asn Phe Ala Val Ser Thr Leu Thr Ser Tyr Asp Trp 
                885                 890                 895     


Ser Asp Arg Asp Asp Ala Thr Gln Gly Arg Lys Leu Ser Pro Phe Val 
            900                 905                 910         


Leu Ser Ala Gly Ser Gly Ser Pro Ser Ala Thr Ser Ile Leu Gln Lys 
        915                 920                 925             


Lys Glu Thr Ser Phe Gly Ser Ser Glu Asn Ile Thr Met Thr Ser Leu 
    930                 935                 940                 


Ser Lys Val Thr Thr Phe Val Ser Glu Asp Ala Leu Pro Glu Thr Thr 
945                 950                 955                 960 


Phe Pro Ala Leu Ala Ser Phe Lys Asp Thr Ile Pro Gln Thr Ser Glu 
                965                 970                 975     


Gln Lys Glu Tyr Glu Asn Arg Asp Tyr Lys Asp Phe Thr Lys Gln Asp 
            980                 985                 990         


Leu Pro Thr Ala Glu Arg Ser Gln  Glu Ala Thr Cys Pro  Ser Pro Ala 
        995                 1000                 1005             


Ser Ser  Gly Ala Ser Gln Glu  Thr Pro Asn Glu Cys  Ser Asp Asp 
    1010                 1015                 1020             


Phe Gly  Glu Phe Gln Ser Glu  Lys Pro Lys Ile Ser  Lys Phe Asp 
    1025                 1030                 1035             


Phe Leu  Val Ala Thr Ser Gln  Ser Lys Met Lys Ser  Ser Glu Glu 
    1040                 1045                 1050             


Met Ile  Lys Ser Glu Leu Ala  Thr Phe Asp Leu Ser  Val Gln Gly 
    1055                 1060                 1065             


Ser His  Lys Arg Ser Leu Ser  Leu Gly Asp Lys Glu  Ile Ser Arg 
    1070                 1075                 1080             


Ser Ser  Pro Ser Pro Ala Leu  Glu Gln Pro Phe Arg  Asp Arg Ser 
    1085                 1090                 1095             


Asn Thr  Leu Asn Glu Lys Pro  Ala Leu Pro Val Ile  Arg Asp Lys 
    1100                 1105                 1110             


Tyr Lys  Asp Leu Thr Gly Glu  Val Glu Glu Asn Glu  Arg Tyr Ala 
    1115                 1120                 1125             


Tyr Glu  Trp Gln Arg Cys Leu  Gly Ser Ala Leu Asn  Val Ile Lys 
    1130                 1135                 1140             


Lys Ala  Asn Asp Thr Leu Asn  Gly Ile Ser Ser Ser  Ser Val Cys 
    1145                 1150                 1155             


Thr Glu  Val Ile Gln Ser Ala  Gln Gly Met Glu Tyr  Leu Leu Gly 
    1160                 1165                 1170             


Val Val  Glu Val Tyr Arg Val  Thr Lys Arg Val Glu  Leu Gly Ile 
    1175                 1180                 1185             


Lys Ala  Thr Ala Val Cys Ser  Glu Lys Leu Gln Gln  Leu Leu Lys 
    1190                 1195                 1200             


Asp Ile  Asp Lys Val Trp Asn  Asn Leu Ile Gly Phe  Met Ser Leu 
    1205                 1210                 1215             


Ala Thr  Leu Thr Pro Asp Glu  Asn Ser Leu Asp Phe  Ser Ser Cys 
    1220                 1225                 1230             


Met Leu  Arg Pro Gly Ile Lys  Asn Ala Gln Glu Leu  Ala Cys Gly 
    1235                 1240                 1245             


Val Cys  Leu Leu Asn Val Asp  Ser Arg Ser Arg Lys  Glu Glu Lys 
    1250                 1255                 1260             


Pro Ala  Glu Glu His Pro Lys  Lys Ala Phe Asn Ser  Glu Thr Asp 
    1265                 1270                 1275             


Ser Phe  Lys Leu Ala Tyr Gly  Gly His Gln Tyr His  Ala Ser Cys 
    1280                 1285                 1290             


Ala Asn  Phe Trp Ile Asn Cys  Val Glu Pro Lys Pro  Pro Gly Leu 
    1295                 1300                 1305             


Val Leu  Pro Asp Leu Leu 
    1310                 


<210> 5798
<211> 176
<212> PRT
<213> Homo sapiens

<400> 5798
Met Ser Asp Asp Asp Ser Arg Ala Ser Thr Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Asn Gln Gln Thr Glu Lys Glu Thr Asn Thr Pro Lys Lys Lys 
            20                  25                  30          


Glu Ser Lys Val Ser Met Ser Lys Asn Ser Lys Leu Leu Ser Thr Ser 
        35                  40                  45              


Ala Lys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg Ser 
    50                  55                  60                  


Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe Phe 
65                  70                  75                  80  


Leu Asp Ile Thr Phe Thr Pro Glu Tyr Pro Phe Lys Pro Pro Lys Val 
                85                  90                  95      


Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly Val 
            100                 105                 110         


Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr Ile 
        115                 120                 125             


Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn Pro 
    130                 135                 140                 


Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn Arg 
145                 150                 155                 160 


Ala Glu His Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala Thr 
                165                 170                 175     


<210> 5799
<211> 2342
<212> PRT
<213> Homo sapiens

<400> 5799
Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu 
1               5                   10                  15      


Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser 
            20                  25                  30          


Pro Leu Gln Asp Leu Arg Gly Gly Asn Glu Arg Val Gln Glu Ser Asn 
        35                  40                  45              


Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr 
    50                  55                  60                  


Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser 
65                  70                  75                  80  


Glu Met Glu Gly Cys Ser Ala Met Val Pro Ser Gln Leu Gln Leu Leu 
                85                  90                  95      


Pro Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Glu Thr Glu 
            100                 105                 110         


Thr Gly Glu Asn Leu Leu Leu Ile Gln Asn Lys Lys Leu Glu Asp Asn 
        115                 120                 125             


Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu Leu Ser Ala Pro Ile His 
    130                 135                 140                 


Thr Gln Met Gln Gln Lys Glu Phe Ser Ile Ile Glu His Thr Arg Glu 
145                 150                 155                 160 


Arg Lys His Ala Asn Asp Gln Thr Val Ile Phe Ser Asp Glu Asn Gln 
                165                 170                 175     


Met Asp Leu Thr Ser Ser His Thr Val Met Ile Thr Lys Gly Leu Leu 
            180                 185                 190         


Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys Ile Asp Thr Thr Ser Phe 
        195                 200                 205             


Leu Ala Asn Leu Lys Leu His Thr Glu Asp Ser Arg Met Lys Lys Glu 
    210                 215                 220                 


Val Asn Phe Ser Val Asp Gln Asn Thr Ser Ser Glu Asn Lys Ile Asp 
225                 230                 235                 240 


Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr Gly Lys Cys Ser Ala Phe 
                245                 250                 255     


Pro Asp Val Pro Asp Lys Glu Asn Phe Glu Ile Pro Ile Tyr Ser Lys 
            260                 265                 270         


Glu Pro Asn Ser Ala Ser Ser Thr His Gln Met His Val Ser Leu Lys 
        275                 280                 285             


Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg Leu Phe Arg Glu Lys Asp 
    290                 295                 300                 


Asp Gly Met Asn Phe Thr Gln Cys His Thr Ala Asn Ile Gln Thr Leu 
305                 310                 315                 320 


Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg Glu Ser Lys Gly Asn Asp 
                325                 330                 335     


Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp Leu Thr Phe Asn His Thr 
            340                 345                 350         


Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe Ser Glu Ile Glu Asn Gln 
        355                 360                 365             


Thr Gln Asn Ala Met Asp Val Thr Thr Gly Tyr Gly Thr Lys Ala Ser 
    370                 375                 380                 


Gly Asn Lys Thr Val Phe Lys Ser Lys Gln Asn Thr Ala Phe Gln Asp 
385                 390                 395                 400 


Leu Ser Ile Asn Ser Ala Asp Lys Ile His Ile Thr Arg Ser His Ile 
                405                 410                 415     


Met Gly Ala Glu Thr His Ile Val Ser Gln Thr Cys Asn Gln Asp Ala 
            420                 425                 430         


Arg Ile Leu Ala Met Thr Pro Glu Ser Ile Tyr Ser Asn Pro Ser Ile 
        435                 440                 445             


Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser Cys Asn Asp Ala Met Glu 
    450                 455                 460                 


Met Thr Lys Cys Leu Ser Asn Met Arg Glu Glu Lys Asn Leu Leu Lys 
465                 470                 475                 480 


His Asp Ser Asn Tyr Ala Lys Met Tyr Cys Asn Pro Asp Ala Met Ser 
                485                 490                 495     


Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly Glu Glu Asn Met Asp Ile 
            500                 505                 510         


Thr Lys Ser His Thr Val Ala Ile Asp Asn Gln Ile Phe Lys Gln Asp 
        515                 520                 525             


Gln Ser Asn Val Gln Ile Ala Ala Ala Pro Thr Pro Glu Lys Glu Met 
    530                 535                 540                 


Met Leu Gln Asn Leu Met Thr Thr Ser Glu Asp Gly Lys Met Asn Val 
545                 550                 555                 560 


Asn Cys Asn Ser Val Pro His Val Ser Lys Glu Arg Ile Gln Gln Ser 
                565                 570                 575     


Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr Asp Arg Lys Thr Glu Leu 
            580                 585                 590         


Leu Ser Gly Glu Asn Met Asp Leu Thr Glu Ser His Thr Ser Asn Leu 
        595                 600                 605             


Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn Leu Ala Pro Glu Ser Thr 
    610                 615                 620                 


Ser Glu Ser His Ser Gln Ser Lys Ser Ser Ser Asp Glu Cys Glu Glu 
625                 630                 635                 640 


Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln Arg Ser Asp Ile Ile Ala 
                645                 650                 655     


Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys Asp Lys Asp Trp Val Leu 
            660                 665                 670         


Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser Pro Gln Ser Ala Asp Cys 
        675                 680                 685             


Asn Gln Glu Ile Ala Thr Ser His Asn Ile Val Tyr Cys Gly Gly Val 
    690                 695                 700                 


Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr Val Ser Trp Glu Gln Ser 
705                 710                 715                 720 


Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser Ser Gly Gln Phe Ser Met 
                725                 730                 735     


Lys Asn His Asp Thr Ala Ile Ser Ser His Thr Val Lys Ser Val Leu 
            740                 745                 750         


Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu Arg Lys Ser Leu Ser Asn 
        755                 760                 765             


Pro Thr Pro Asp Tyr Cys His Asp Lys Met Ile Ile Cys Ser Glu Glu 
    770                 775                 780                 


Glu Gln Asn Met Asp Leu Thr Lys Ser His Thr Val Val Ile Gly Phe 
785                 790                 795                 800 


Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys Thr Asn Leu Glu His Thr 
                805                 810                 815     


Thr Gly Gln Leu Thr Thr Met Asn Arg Gln Ile Ala Val Lys Val Glu 
            820                 825                 830         


Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser Gly Val Leu Lys Ser Asn 
        835                 840                 845             


Cys Ile Met Asp Val Leu Glu Asp Glu Ser Val Gln Lys Pro Lys Phe 
    850                 855                 860                 


Pro Lys Glu Lys Gln Asn Val Lys Ile Trp Gly Arg Lys Ser Val Gly 
865                 870                 875                 880 


Gly Pro Lys Ile Asp Lys Thr Ile Val Phe Ser Glu Asp Asp Lys Asn 
                885                 890                 895     


Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile Glu Ile Asn His Arg Pro 
            900                 905                 910         


Leu Leu Glu Lys Arg Asp Cys His Leu Val Pro Leu Ala Gly Thr Ser 
        915                 920                 925             


Glu Thr Ile Leu Tyr Thr Cys Arg Gln Asp Asp Met Glu Ile Thr Arg 
    930                 935                 940                 


Ser His Thr Thr Ala Leu Glu Cys Lys Thr Val Ser Pro Asp Glu Ile 
945                 950                 955                 960 


Thr Thr Arg Pro Met Asp Lys Thr Val Val Phe Val Asp Asn His Val 
                965                 970                 975     


Glu Leu Glu Met Thr Glu Ser His Thr Val Phe Ile Asp Tyr Gln Glu 
            980                 985                 990         


Lys Glu Arg Thr Asp Arg Pro Asn  Phe Glu Leu Ser Gln  Arg Lys Ser 
        995                 1000                 1005             


Leu Gly  Thr Pro Thr Val Ile  Cys Thr Pro Thr Glu  Glu Ser Val 
    1010                 1015                 1020             


Phe Phe  Pro Gly Asn Gly Glu  Ser Asp Arg Leu Val  Ala Asn Asp 
    1025                 1030                 1035             


Ser Gln  Leu Thr Pro Leu Glu  Glu Trp Ser Asn Asn  Arg Gly Pro 
    1040                 1045                 1050             


Val Glu  Val Ala Asp Asn Met  Glu Leu Ser Lys Ser  Ala Thr Cys 
    1055                 1060                 1065             


Lys Asn  Ile Lys Asp Val Gln  Ser Pro Gly Phe Leu  Asn Glu Pro 
    1070                 1075                 1080             


Leu Ser  Ser Lys Ser Gln Arg  Arg Lys Ser Leu Lys  Leu Lys Asn 
    1085                 1090                 1095             


Asp Lys  Thr Ile Val Phe Ser  Glu Asn His Lys Asn  Asp Met Asp 
    1100                 1105                 1110             


Ile Thr  Gln Ser Cys Met Val  Glu Ile Asp Asn Glu  Ser Ala Leu 
    1115                 1120                 1125             


Glu Asp  Lys Glu Asp Phe His  Leu Ala Gly Ala Ser  Lys Thr Ile 
    1130                 1135                 1140             


Leu Tyr  Ser Cys Gly Gln Asp  Asp Met Glu Ile Thr  Arg Ser His 
    1145                 1150                 1155             


Thr Thr  Ala Leu Glu Cys Lys  Thr Leu Leu Pro Asn  Glu Ile Ala 
    1160                 1165                 1170             


Ile Arg  Pro Met Asp Lys Thr  Val Leu Phe Thr Asp  Asn Tyr Ser 
    1175                 1180                 1185             


Asp Leu  Glu Val Thr Asp Ser  His Thr Val Phe Ile  Asp Cys Gln 
    1190                 1195                 1200             


Ala Thr  Glu Lys Ile Leu Glu  Glu Asn Pro Lys Phe  Gly Ile Gly 
    1205                 1210                 1215             


Lys Gly  Lys Asn Leu Gly Val  Ser Phe Pro Lys Asp  Asn Ser Cys 
    1220                 1225                 1230             


Val Gln  Glu Ile Ala Glu Lys  Gln Ala Leu Ala Val  Gly Asn Lys 
    1235                 1240                 1245             


Ile Val  Leu His Thr Glu Gln  Lys Gln Gln Leu Phe  Ala Ala Thr 
    1250                 1255                 1260             


Asn Arg  Thr Thr Asn Glu Ile  Ile Lys Phe His Ser  Ala Ala Met 
    1265                 1270                 1275             


Asp Glu  Lys Val Ile Gly Lys  Val Val Asp Gln Ala  Cys Thr Leu 
    1280                 1285                 1290             


Glu Lys  Ala Gln Val Glu Ser  Cys Gln Leu Asn Asn  Arg Asp Arg 
    1295                 1300                 1305             


Arg Asn  Val Asp Phe Thr Ser  Ser His Ala Thr Ala  Val Cys Gly 
    1310                 1315                 1320             


Ser Ser  Asp Asn Tyr Ser Cys  Leu Pro Asn Val Ile  Ser Cys Thr 
    1325                 1330                 1335             


Asp Asn  Leu Glu Gly Ser Ala  Met Leu Leu Cys Asp  Lys Asp Glu 
    1340                 1345                 1350             


Glu Lys  Ala Asn Tyr Cys Pro  Val Gln Asn Asp Leu  Ala Tyr Ala 
    1355                 1360                 1365             


Asn Asp  Phe Ala Ser Glu Tyr  Tyr Leu Glu Ser Glu  Gly Gln Pro 
    1370                 1375                 1380             


Leu Ser  Ala Pro Cys Pro Leu  Leu Glu Lys Glu Glu  Val Ile Gln 
    1385                 1390                 1395             


Thr Ser  Thr Lys Gly Gln Leu  Asp Cys Val Ile Thr  Leu His Lys 
    1400                 1405                 1410             


Asp Gln  Asp Leu Ile Lys Asp  Pro Arg Asn Leu Leu  Ala Asn Gln 
    1415                 1420                 1425             


Thr Leu  Val Tyr Ser Gln Asp  Leu Gly Glu Met Thr  Lys Leu Asn 
    1430                 1435                 1440             


Ser Lys  Arg Val Ser Phe Lys  Leu Pro Lys Asp Gln  Met Lys Val 
    1445                 1450                 1455             


Tyr Val  Asp Asp Ile Tyr Val  Ile Pro Gln Pro His  Phe Ser Thr 
    1460                 1465                 1470             


Asp Gln  Pro Pro Leu Pro Lys  Lys Gly Gln Ser Ser  Ile Asn Lys 
    1475                 1480                 1485             


Glu Glu  Val Ile Leu Ser Lys  Ala Gly Asn Lys Ser  Leu Asn Ile 
    1490                 1495                 1500             


Ile Glu  Asn Ser Ser Ala Pro  Ile Cys Glu Asn Lys  Pro Lys Ile 
    1505                 1510                 1515             


Leu Asn  Ser Glu Glu Trp Phe  Ala Ala Ala Cys Lys  Lys Glu Leu 
    1520                 1525                 1530             


Lys Glu  Asn Ile Gln Thr Thr  Asn Tyr Asn Thr Ala  Leu Asp Phe 
    1535                 1540                 1545             


His Ser  Asn Ser Asp Val Thr  Lys Gln Val Ile Gln  Thr His Val 
    1550                 1555                 1560             


Asn Ala  Gly Glu Ala Pro Asp  Pro Val Ile Thr Ser  Asn Val Pro 
    1565                 1570                 1575             


Cys Phe  His Ser Ile Lys Pro  Asn Leu Asn Asn Leu  Asn Gly Lys 
    1580                 1585                 1590             


Thr Gly  Glu Phe Leu Ala Phe  Gln Thr Val His Leu  Pro Pro Leu 
    1595                 1600                 1605             


Pro Glu  Gln Leu Leu Glu Leu  Gly Asn Lys Ala His  Asn Asp Met 
    1610                 1615                 1620             


His Ile  Val Gln Ala Thr Glu  Ile His Asn Ile Asn  Ile Ile Ser 
    1625                 1630                 1635             


Ser Asn  Ala Lys Asp Ser Arg  Asp Glu Glu Asn Lys  Lys Ser His 
    1640                 1645                 1650             


Asn Gly  Ala Glu Thr Thr Ser  Leu Pro Pro Lys Thr  Val Phe Lys 
    1655                 1660                 1665             


Asp Lys  Val Arg Arg Cys Ser  Leu Gly Ile Phe Leu  Pro Arg Leu 
    1670                 1675                 1680             


Pro Asn  Lys Arg Asn Cys Ser  Val Thr Gly Ile Asp  Asp Leu Glu 
    1685                 1690                 1695             


Gln Ile  Pro Ala Asp Thr Thr  Asp Ile Asn His Leu  Glu Thr Gln 
    1700                 1705                 1710             


Pro Val  Ser Ser Lys Asp Ser  Gly Ile Gly Ser Val  Ala Gly Lys 
    1715                 1720                 1725             


Leu Asn  Leu Ser Pro Ser Gln  Tyr Ile Asn Glu Glu  Asn Leu Pro 
    1730                 1735                 1740             


Val Tyr  Pro Asp Glu Ile Asn  Ser Ser Asp Ser Ile  Asn Ile Glu 
    1745                 1750                 1755             


Thr Glu  Glu Lys Ala Leu Ile  Glu Thr Tyr Gln Lys  Glu Ile Ser 
    1760                 1765                 1770             


Pro Tyr  Glu Asn Lys Met Gly  Lys Thr Cys Asn Ser  Gln Lys Arg 
    1775                 1780                 1785             


Thr Trp  Val Gln Glu Glu Glu  Asp Ile His Lys Glu  Lys Lys Ile 
    1790                 1795                 1800             


Arg Lys  Asn Glu Ile Lys Phe  Ser Asp Thr Thr Gln  Asp Arg Glu 
    1805                 1810                 1815             


Ile Phe  Asp His His Thr Glu  Glu Asp Ile Asp Lys  Ser Ala Asn 
    1820                 1825                 1830             


Ser Val  Leu Ile Lys Asn Leu  Ser Arg Thr Pro Ser  Ser Cys Ser 
    1835                 1840                 1845             


Ser Ser  Leu Asp Ser Ile Lys  Ala Asp Gly Thr Ser  Leu Asp Phe 
    1850                 1855                 1860             


Ser Thr  Tyr Arg Ser Ser Gln  Met Glu Ser Gln Phe  Leu Arg Asp 
    1865                 1870                 1875             


Thr Ile  Cys Glu Glu Ser Leu  Arg Glu Lys Leu Gln  Asp Gly Arg 
    1880                 1885                 1890             


Ile Thr  Ile Arg Glu Phe Phe  Ile Leu Leu Gln Val  His Ile Leu 
    1895                 1900                 1905             


Ile Gln  Lys Pro Arg Gln Ser  Asn Leu Pro Gly Asn  Phe Thr Val 
    1910                 1915                 1920             


Asn Thr  Pro Pro Thr Pro Glu  Asp Leu Met Leu Ser  Gln Tyr Val 
    1925                 1930                 1935             


Tyr Arg  Pro Lys Ile Gln Ile  Tyr Arg Glu Asp Cys  Glu Ala Arg 
    1940                 1945                 1950             


Arg Gln  Lys Ile Glu Glu Leu  Lys Leu Ser Ala Ser  Asn Gln Asp 
    1955                 1960                 1965             


Lys Leu  Leu Val Asp Ile Asn  Lys Asn Leu Trp Glu  Lys Met Arg 
    1970                 1975                 1980             


His Cys  Ser Asp Lys Glu Leu  Lys Ala Phe Gly Ile  Tyr Leu Asn 
    1985                 1990                 1995             


Lys Ile  Lys Ser Cys Phe Thr  Lys Met Thr Lys Val  Phe Thr His 
    2000                 2005                 2010             


Gln Gly  Lys Val Ala Leu Tyr  Gly Lys Leu Val Gln  Ser Ala Gln 
    2015                 2020                 2025             


Asn Glu  Arg Glu Lys Leu Gln  Ile Lys Ile Asp Glu  Met Asp Lys 
    2030                 2035                 2040             


Ile Leu  Lys Lys Ile Asp Asn  Cys Leu Thr Glu Met  Glu Thr Glu 
    2045                 2050                 2055             


Thr Lys  Asn Leu Glu Asp Glu  Glu Lys Asn Asn Pro  Val Glu Glu 
    2060                 2065                 2070             


Trp Asp  Ser Glu Met Arg Ala  Ala Glu Lys Glu Leu  Glu Gln Leu 
    2075                 2080                 2085             


Lys Thr  Glu Glu Glu Glu Leu  Gln Arg Asn Leu Leu  Glu Leu Glu 
    2090                 2095                 2100             


Val Gln  Lys Glu Gln Thr Leu  Ala Gln Ile Asp Phe  Met Gln Lys 
    2105                 2110                 2115             


Gln Arg  Asn Arg Thr Glu Glu  Leu Leu Asp Gln Leu  Ser Leu Ser 
    2120                 2125                 2130             


Glu Trp  Asp Val Val Glu Trp  Ser Asp Asp Gln Ala  Val Phe Thr 
    2135                 2140                 2145             


Phe Val  Tyr Asp Thr Ile Gln  Leu Thr Ile Thr Phe  Glu Glu Ser 
    2150                 2155                 2160             


Val Val  Gly Phe Pro Phe Leu  Asp Lys Arg Tyr Arg  Lys Ile Val 
    2165                 2170                 2175             


Asp Val  Asn Phe Gln Ser Leu  Leu Asp Glu Asp Gln  Ala Pro Pro 
    2180                 2185                 2190             


Ser Ser  Leu Leu Val His Lys  Leu Ile Phe Gln Tyr  Val Glu Glu 
    2195                 2200                 2205             


Lys Glu  Ser Trp Lys Lys Thr  Cys Thr Thr Gln His  Gln Leu Pro 
    2210                 2215                 2220             


Lys Met  Leu Glu Glu Phe Ser  Leu Val Val His His  Cys Arg Leu 
    2225                 2230                 2235             


Leu Gly  Glu Glu Ile Glu Tyr  Leu Lys Arg Trp Gly  Pro Asn Tyr 
    2240                 2245                 2250             


Asn Leu  Met Asn Ile Asp Ile  Asn Asn Asn Glu Leu  Arg Leu Leu 
    2255                 2260                 2265             


Phe Ser  Ser Ser Ala Ala Phe  Ala Lys Phe Glu Ile  Thr Leu Phe 
    2270                 2275                 2280             


Leu Ser  Ala Tyr Tyr Pro Ser  Val Pro Leu Pro Ser  Thr Ile Gln 
    2285                 2290                 2295             


Asn His  Val Gly Asn Thr Ser  Gln Asp Asp Ile Ala  Thr Ile Leu 
    2300                 2305                 2310             


Ser Lys  Val Pro Leu Glu Asn  Asn Tyr Leu Lys Asn  Val Val Lys 
    2315                 2320                 2325             


Gln Ile  Tyr Gln Asp Leu Phe  Gln Asp Cys His Phe  Tyr His 
    2330                 2335                 2340         


<210> 5800
<211> 545
<212> PRT
<213> Homo sapiens

<400> 5800
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Ile Leu Val Lys Thr Met Ile 
        435                 440                 445             


Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu 
    450                 455                 460                 


Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg 
465                 470                 475                 480 


Glu Cys Glu Ser Leu Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln 
                485                 490                 495     


Pro Pro Gly His Arg Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu 
            500                 505                 510         


Val Arg Gly Ser Pro Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly 
        515                 520                 525             


Ser Pro Ala Arg Met His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro 
    530                 535                 540                 


Glu 
545 


<210> 5801
<211> 110
<212> PRT
<213> Homo sapiens

<400> 5801
Met Pro Lys Arg Ser Cys Pro Phe Ala Asp Val Ala Pro Leu Gln Leu 
1               5                   10                  15      


Lys Val Arg Val Ser Gln Arg Glu Leu Ser Arg Gly Val Cys Ala Glu 
            20                  25                  30          


Arg Tyr Ser Gln Glu Val Phe Asp Pro Ser Gly Val Ala Ser Ile Ala 
        35                  40                  45              


Cys Ser Ser Cys Val Arg Ala Val Asp Gly Lys Ala Val Cys Gly Gln 
    50                  55                  60                  


Cys Glu Arg Ala Leu Cys Gly Gln Cys Val Arg Thr Cys Trp Gly Cys 
65                  70                  75                  80  


Gly Ser Val Ala Cys Thr Leu Cys Gly Leu Val Asp Cys Ser Asp Met 
                85                  90                  95      


Tyr Glu Lys Val Leu Cys Thr Ser Cys Ala Met Phe Glu Thr 
            100                 105                 110 


<210> 5802
<211> 750
<212> PRT
<213> Homo sapiens

<400> 5802
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala 
    130                 135                 140                 


Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr 
145                 150                 155                 160 


Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp 
                165                 170                 175     


Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys 
            180                 185                 190         


Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys Gln Val Ala Trp Ile 
        195                 200                 205             


Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu Leu Leu Pro Val Cys 
    210                 215                 220                 


Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala 
225                 230                 235                 240 


Glu Asp Asn Leu Leu Ala Leu Gly Leu Lys His Phe Glu Gly Thr Glu 
                245                 250                 255     


Phe Leu Asn Pro Leu Ile Ser Lys Tyr Leu Leu Thr Cys Lys Thr Ala 
            260                 265                 270         


Arg Gln Leu Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala Pro 
        275                 280                 285             


Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu 
    290                 295                 300                 


Gly Lys Cys Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro Ile 
305                 310                 315                 320 


Glu Arg Glu Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro 
                325                 330                 335     


Ser Ile Gln Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu Val 
            340                 345                 350         


Gly Asn Met Thr Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu Glu 
        355                 360                 365             


Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu Leu 
    370                 375                 380                 


Pro Lys Gly Val Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe Pro 
385                 390                 395                 400 


Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu Leu 
                405                 410                 415     


Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys Thr 
            420                 425                 430         


Pro Ala Gln Ser Thr His Ser Glu Ala Pro Pro Ser Lys Met Val Leu 
        435                 440                 445             


Arg Ile Pro His Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val Pro 
    450                 455                 460                 


Gly Val Pro Pro Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser Pro 
465                 470                 475                 480 


Ala Ala Leu Pro Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro Leu 
                485                 490                 495     


Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val Met 
            500                 505                 510         


Met Pro Ser Pro Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg Arg 
        515                 520                 525             


Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys Pro 
    530                 535                 540                 


Ala Pro Val Ile His Pro Ala Ser Val Ile Phe Thr Val Pro Ala Thr 
545                 550                 555                 560 


Thr Val Lys Ile Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln Pro 
                565                 570                 575     


Val Asn Ala Ala Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala Thr 
            580                 585                 590         


Leu Leu Val Asn Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro Leu 
        595                 600                 605             


Val Ala Ser Ser Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val Asn 
    610                 615                 620                 


Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys Ala His Met Asn Val Asp 
625                 630                 635                 640 


Ile Ala Cys Ala Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu Glu 
                645                 650                 655     


Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val Phe 
            660                 665                 670         


Pro Lys Val Glu His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln Cys 
        675                 680                 685             


Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val Lys 
    690                 695                 700                 


Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile Gln 
705                 710                 715                 720 


Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val Lys 
                725                 730                 735     


Met Glu Pro Glu Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
            740                 745                 750 


<210> 5803
<211> 867
<212> PRT
<213> Homo sapiens

<400> 5803
Met Gln Ala Glu Ala Ala Asp Trp Phe Ser Ser Met Pro Phe Gln Lys 
1               5                   10                  15      


His Val Tyr Tyr Pro Leu Ala Ser Gly Pro Glu Gly Pro Asp Val Ala 
            20                  25                  30          


Val Ala Ala Ala Ala Ala Gly Ala Ala Ser Met Ala Cys Ala Pro Pro 
        35                  40                  45              


Ser Ala Ala Ser Gly Pro Leu Pro Phe Phe Gln Phe Arg Pro Arg Leu 
    50                  55                  60                  


Glu Ser Val Asp Trp Arg Arg Leu Ser Ala Ile Asp Val Asp Lys Val 
65                  70                  75                  80  


Ala Gly Ala Val Asp Val Leu Thr Leu Gln Glu Asn Ile Met Asn Ile 
                85                  90                  95      


Thr Phe Cys Lys Leu Glu Asp Glu Lys Cys Pro His Cys Gln Ser Gly 
            100                 105                 110         


Val Asp Pro Val Leu Leu Lys Leu Ile Arg Leu Ala Gln Phe Thr Ile 
        115                 120                 125             


Glu Tyr Leu Leu His Ser Gln Glu Phe Leu Thr Ser Gln Leu His Thr 
    130                 135                 140                 


Leu Glu Glu Arg Leu Arg Leu Ser His Cys Asp Gly Glu Gln Ser Lys 
145                 150                 155                 160 


Lys Leu Leu Thr Lys Gln Ala Gly Glu Ile Lys Thr Leu Lys Glu Glu 
                165                 170                 175     


Cys Lys Arg Arg Lys Lys Met Ile Ser Thr Gln Gln Leu Met Ile Glu 
            180                 185                 190         


Ala Lys Ala Asn Tyr Tyr Gln Cys His Phe Cys Asp Lys Ala Phe Met 
        195                 200                 205             


Asn Gln Ala Phe Leu Gln Ser His Ile Gln Arg Arg His Thr Glu Glu 
    210                 215                 220                 


Asn Ser His Phe Glu Tyr Gln Lys Asn Ala Gln Ile Glu Lys Leu Arg 
225                 230                 235                 240 


Ser Glu Ile Val Val Leu Lys Glu Glu Leu Gln Leu Thr Arg Ser Glu 
                245                 250                 255     


Leu Glu Ala Ala His His Ala Ser Ala Val Arg Phe Ser Lys Glu Tyr 
            260                 265                 270         


Glu Met Gln Lys Thr Lys Glu Glu Asp Phe Leu Lys Leu Phe Asp Arg 
        275                 280                 285             


Trp Lys Glu Glu Glu Lys Glu Lys Leu Val Asp Glu Met Glu Lys Val 
    290                 295                 300                 


Lys Glu Met Phe Met Lys Glu Phe Lys Glu Leu Thr Ser Lys Asn Ser 
305                 310                 315                 320 


Ala Leu Glu Tyr Gln Leu Ser Glu Ile Gln Lys Ser Asn Met Gln Ile 
                325                 330                 335     


Lys Ser Asn Ile Gly Thr Leu Lys Asp Ala His Glu Phe Lys Glu Asp 
            340                 345                 350         


Arg Ser Pro Tyr Pro Gln Asp Phe His Asn Val Met Gln Leu Leu Asp 
        355                 360                 365             


Ser Gln Glu Ser Lys Trp Thr Ala Arg Val Gln Ala Ile His Gln Glu 
    370                 375                 380                 


His Lys Lys Glu Lys Gly Arg Leu Leu Ser His Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Thr Ser Met Ile Asp Asp Leu Asn Ala Ser Asn Val Phe Tyr Lys Lys 
                405                 410                 415     


Arg Ile Glu Glu Leu Gly Gln Arg Leu Gln Glu Gln Asn Glu Leu Ile 
            420                 425                 430         


Ile Thr Gln Arg Gln Gln Ile Lys Asp Phe Thr Cys Asn Pro Leu Asn 
        435                 440                 445             


Ser Ile Ser Glu Pro Lys Gly Asn Pro Leu Ala Trp Gln Ala Phe Glu 
    450                 455                 460                 


Ser Gln Pro Ala Ala Pro Ala Val Pro Met Asn Ala Pro Ala Leu His 
465                 470                 475                 480 


Thr Leu Glu Thr Lys Ser Ser Leu Pro Met Val His Glu Gln Ala Phe 
                485                 490                 495     


Ser Ser His Ile Leu Glu Pro Ile Glu Glu Leu Ser Glu Glu Glu Lys 
            500                 505                 510         


Gly Arg Glu Asn Glu Gln Lys Leu Asn Asn Asn Lys Met His Leu Arg 
        515                 520                 525             


Lys Ala Leu Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met 
    530                 535                 540                 


Val Glu Gln Asn Leu Met Glu Lys Leu Glu Thr Leu Gly Ile Asn Ala 
545                 550                 555                 560 


Asp Ile Arg Gly Ile Ser Ser Asp Gln Leu His Arg Val Leu Lys Ser 
                565                 570                 575     


Val Glu Ser Glu Arg His Lys Gln Glu Arg Glu Ile Pro Asn Phe His 
            580                 585                 590         


Gln Ile Arg Glu Phe Leu Glu His Gln Val Ser Cys Lys Ile Glu Glu 
        595                 600                 605             


Lys Ala Leu Leu Ser Ser Asp Gln Cys Ser Val Ser Gln Met Asp Thr 
    610                 615                 620                 


Leu Ser Thr Gly Glu Val Pro Lys Met Ile Gln Leu Pro Ser Lys Asn 
625                 630                 635                 640 


Arg Gln Leu Ile Arg Gln Lys Ala Val Ser Thr Asp Arg Thr Ser Val 
                645                 650                 655     


Pro Lys Ile Lys Lys Asn Val Met Glu Asp Pro Phe Pro Arg Lys Ser 
            660                 665                 670         


Ser Thr Ile Thr Thr Pro Pro Phe Ser Ser Glu Glu Glu Gln Glu Asp 
        675                 680                 685             


Asp Asp Leu Ile Arg Ala Tyr Ala Ser Pro Gly Pro Leu Pro Val Pro 
    690                 695                 700                 


Pro Pro Gln Asn Lys Gly Ser Phe Gly Lys Asn Thr Val Lys Ser Asp 
705                 710                 715                 720 


Ala Asp Gly Thr Glu Gly Ser Glu Ile Glu Asp Thr Asp Asp Ser Pro 
                725                 730                 735     


Lys Pro Ala Gly Val Ala Val Lys Thr Pro Thr Glu Lys Val Glu Lys 
            740                 745                 750         


Met Phe Pro His Arg Lys Asn Val Asn Lys Pro Val Gly Gly Thr Asn 
        755                 760                 765             


Val Pro Glu Met Phe Ile Lys Lys Glu Glu Leu Gln Glu Leu Lys Cys 
    770                 775                 780                 


Ala Asp Val Glu Asp Glu Asp Trp Asp Ile Ser Ser Leu Glu Glu Glu 
785                 790                 795                 800 


Ile Ser Leu Gly Lys Lys Ser Gly Lys Glu Gln Lys Glu Pro Pro Pro 
                805                 810                 815     


Ala Lys Asn Glu Pro His Phe Ala His Val Leu Asn Ala Trp Gly Ala 
            820                 825                 830         


Phe Asn Pro Lys Gly Pro Lys Gly Glu Gly Leu Gln Glu Asn Glu Ser 
        835                 840                 845             


Ser Thr Leu Lys Ser Ser Leu Val Thr Val Thr Asp Trp Ser Asp Thr 
    850                 855                 860                 


Ser Asp Val 
865         


<210> 5804
<211> 619
<212> PRT
<213> Homo sapiens

<400> 5804
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu Ala Gln Val Met Leu Ala Leu Ala Ser His Leu Ser 
                85                  90                  95      


Thr Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu 
            100                 105                 110         


Cys Gln Glu Asn Gln Trp Leu Arg Asp Glu Leu Ala Gly Thr Gln Gln 
        115                 120                 125             


Arg Leu Gln Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu Glu Lys 
    130                 135                 140                 


Lys His Leu Glu Phe Leu Gly Gln Leu Arg Gln Tyr Asp Glu Asp Gly 
145                 150                 155                 160 


His Thr Ser Glu Glu Lys Glu Gly Asp Ala Thr Lys Asp Ser Leu Asp 
                165                 170                 175     


Asp Leu Phe Pro Asn Glu Glu Glu Glu Asp Pro Ser Asn Gly Leu Ser 
            180                 185                 190         


Arg Gly Gln Gly Ala Thr Ala Ala Gln Gln Gly Gly Tyr Glu Ile Pro 
        195                 200                 205             


Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala Ala Gln 
    210                 215                 220                 


Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu Glu Asp 
225                 230                 235                 240 


Leu Glu Arg Thr Ser Gly Arg Gly His Pro Asp Val Ala Thr Met Leu 
                245                 250                 255     


Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys Glu Ala 
            260                 265                 270         


Ala His Leu Leu Asn Asp Ala Leu Ser Ile Arg Glu Ser Thr Leu Gly 
        275                 280                 285             


Pro Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu Ala Val Leu 
    290                 295                 300                 


Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu Cys Gln Arg 
305                 310                 315                 320 


Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Thr Asn His Pro Asp Val 
                325                 330                 335     


Ala Lys Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn Gln Gly Lys 
            340                 345                 350         


Tyr Glu Ala Val Glu Arg Tyr Tyr Gln Arg Ala Leu Ala Ile Tyr Glu 
        355                 360                 365             


Gly Gln Leu Gly Pro Asp Asn Pro Asn Val Ala Arg Thr Lys Asn Asn 
    370                 375                 380                 


Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Tyr Ala Glu Ala Glu Thr 
385                 390                 395                 400 


Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Val Gln Glu Phe Gly Ser 
                405                 410                 415     


Val Asp Asp Asp His Lys Pro Ile Trp Met His Ala Glu Glu Arg Glu 
            420                 425                 430         


Glu Met Ser Lys Ser Arg His His Glu Gly Gly Thr Pro Tyr Ala Glu 
        435                 440                 445             


Tyr Gly Gly Trp Tyr Lys Ala Cys Lys Val Ser Ser Pro Thr Val Asn 
    450                 455                 460                 


Thr Thr Leu Arg Asn Leu Gly Ala Leu Tyr Arg Arg Gln Gly Lys Leu 
465                 470                 475                 480 


Glu Ala Ala Glu Thr Leu Glu Glu Cys Ala Leu Arg Ser Arg Arg Gln 
                485                 490                 495     


Gly Thr Asp Pro Ile Ser Gln Thr Lys Val Ala Glu Leu Leu Gly Glu 
            500                 505                 510         


Ser Asp Gly Arg Arg Thr Ser Gln Glu Gly Pro Gly Asp Ser Val Lys 
        515                 520                 525             


Phe Glu Gly Gly Glu Asp Ala Ser Val Ala Val Glu Trp Ser Gly Asp 
    530                 535                 540                 


Gly Ser Gly Thr Leu Gln Arg Ser Gly Ser Leu Gly Lys Ile Arg Asp 
545                 550                 555                 560 


Val Leu Arg Arg Ser Ser Glu Leu Leu Val Arg Lys Leu Gln Gly Thr 
                565                 570                 575     


Glu Pro Arg Pro Ser Ser Ser Asn Met Lys Arg Ala Ala Ser Leu Asn 
            580                 585                 590         


Tyr Leu Asn Gln Pro Ser Ala Ala Pro Leu Gln Val Ser Arg Gly Leu 
        595                 600                 605             


Ser Ala Ser Thr Met Asp Leu Ser Ser Ser Ser 
    610                 615                 


<210> 5805
<211> 378
<212> PRT
<213> Homo sapiens

<400> 5805
Met Lys Glu Gln Leu Pro Asp Leu His Ser His Phe Ser Asp Leu Asn 
1               5                   10                  15      


Leu Glu Ala His Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe Thr 
            20                  25                  30          


Ala Lys Phe Pro Leu Cys Met Val Phe His Ile Ile Asp Leu Leu Leu 
        35                  40                  45              


Cys Glu Gly Leu Asn Ile Ile Phe His Val Ala Leu Ala Leu Leu Lys 
    50                  55                  60                  


Thr Ser Lys Glu Asp Leu Leu Gln Ala Asp Phe Glu Gly Ala Leu Lys 
65                  70                  75                  80  


Phe Phe Arg Val Gln Leu Pro Lys Arg Tyr Arg Ala Glu Glu Asn Ala 
                85                  90                  95      


Arg Arg Leu Met Glu Gln Ala Cys Asn Ile Lys Val Pro Thr Lys Lys 
            100                 105                 110         


Leu Lys Lys Tyr Glu Lys Glu Tyr Gln Thr Met Arg Glu Ser Gln Leu 
        115                 120                 125             


Gln Gln Glu Asp Pro Met Asp Arg Tyr Lys Arg Glu Asn Arg Arg Leu 
    130                 135                 140                 


Gln Glu Ala Ser Met Arg Leu Glu Gln Glu Asn Asp Asp Leu Ala His 
145                 150                 155                 160 


Glu Leu Val Thr Ser Lys Ile Ala Leu Arg Asn Asp Leu Asp Gln Ala 
                165                 170                 175     


Glu Asp Lys Ala Asp Val Leu Asn Lys Glu Leu Leu Leu Thr Lys Gln 
            180                 185                 190         


Arg Leu Val Glu Thr Glu Glu Glu Lys Arg Lys Gln Glu Glu Glu Thr 
        195                 200                 205             


Ala Gln Leu Lys Glu Val Phe Arg Lys Gln Leu Glu Lys Ala Glu Tyr 
    210                 215                 220                 


Glu Ile Lys Lys Thr Thr Ala Ile Ile Ala Glu Tyr Lys Gln Ile Cys 
225                 230                 235                 240 


Ser Gln Leu Ser Thr Arg Leu Glu Lys Gln Gln Ala Ala Ser Lys Glu 
                245                 250                 255     


Glu Leu Glu Val Val Lys Gly Lys Met Met Ala Cys Lys His Cys Ser 
            260                 265                 270         


Asp Ile Phe Ser Lys Glu Gly Ala Leu Lys Leu Ala Ala Thr Gly Arg 
        275                 280                 285             


Glu Asp Gln Gly Ile Glu Thr Asp Asp Glu Lys Asp Ser Leu Lys Lys 
    290                 295                 300                 


Gln Leu Arg Glu Met Glu Leu Glu Leu Ala Gln Thr Lys Leu Gln Leu 
305                 310                 315                 320 


Val Glu Ala Lys Cys Lys Ile Gln Glu Leu Glu His Gln Arg Gly Ala 
                325                 330                 335     


Leu Met Asn Glu Ile Gln Ala Ala Lys Asn Ser Trp Phe Ser Lys Thr 
            340                 345                 350         


Leu Asn Ser Ile Lys Thr Ala Thr Gly Thr Gln Pro Leu Gln Pro Ala 
        355                 360                 365             


Pro Val Thr Gln Pro Pro Lys Glu Ser Thr 
    370                 375             


<210> 5806
<211> 876
<212> PRT
<213> Homo sapiens

<400> 5806
Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe 
1               5                   10                  15      


Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg 
            20                  25                  30          


Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu 
        35                  40                  45              


Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu 
    50                  55                  60                  


Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met 
65                  70                  75                  80  


Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr 
                85                  90                  95      


Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro 
            100                 105                 110         


Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu 
        115                 120                 125             


Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val 
    130                 135                 140                 


Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp 
145                 150                 155                 160 


Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys 
                165                 170                 175     


Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys 
            180                 185                 190         


Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys 
        195                 200                 205             


Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe 
    210                 215                 220                 


Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile 
225                 230                 235                 240 


Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys 
                245                 250                 255     


Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu 
            260                 265                 270         


Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu 
        275                 280                 285             


Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp 
    290                 295                 300                 


Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser 
305                 310                 315                 320 


Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu 
                325                 330                 335     


Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg 
            340                 345                 350         


Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser 
        355                 360                 365             


Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu 
    370                 375                 380                 


Glu Ala Glu Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu 
385                 390                 395                 400 


Trp Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro 
                405                 410                 415     


Leu His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile 
            420                 425                 430         


Ser Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met 
        435                 440                 445             


Arg Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg 
    450                 455                 460                 


Gly Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp 
465                 470                 475                 480 


Asn Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val 
                485                 490                 495     


Asn Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln 
            500                 505                 510         


His Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile 
        515                 520                 525             


His Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr 
    530                 535                 540                 


Pro Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn 
545                 550                 555                 560 


Ile Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu 
                565                 570                 575     


Leu Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly 
            580                 585                 590         


Asn Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val 
        595                 600                 605             


Leu Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr 
    610                 615                 620                 


Tyr Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys 
625                 630                 635                 640 


Gly Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His 
                645                 650                 655     


Gly Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro 
            660                 665                 670         


Leu Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met 
        675                 680                 685             


Gly Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn 
    690                 695                 700                 


Thr Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys 
705                 710                 715                 720 


Lys Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His 
                725                 730                 735     


Ala Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn 
            740                 745                 750         


Phe Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala 
        755                 760                 765             


Gln Pro Pro Gly Pro Ala Gln Ile Leu Pro Pro Gly Leu Thr Pro Gly 
    770                 775                 780                 


Leu Pro Tyr Pro His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln 
785                 790                 795                 800 


Pro Arg Pro Pro Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala 
                805                 810                 815     


Val Pro Thr Gly Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly 
            820                 825                 830         


Arg Gly Asn Tyr Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys 
        835                 840                 845             


Pro Arg Asn Arg Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr 
    850                 855                 860                 


Arg Asp Leu Asp Ala Pro Asp Asp Val Asp Phe Phe 
865                 870                 875     


<210> 5807
<211> 496
<212> PRT
<213> Homo sapiens

<400> 5807
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser Gly 
        115                 120                 125             


Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu Phe 
    130                 135                 140                 


Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn Ala 
145                 150                 155                 160 


Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro Ala 
                165                 170                 175     


Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile Val 
            180                 185                 190         


Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile Ser 
        195                 200                 205             


Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu Tyr 
    210                 215                 220                 


Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val Met 
225                 230                 235                 240 


Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn Lys 
                245                 250                 255     


Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu Gly 
            260                 265                 270         


Phe Lys Val Pro Gln Ala Gln Pro Thr Lys Pro Ala Leu Lys Ser Glu 
        275                 280                 285             


Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr Phe 
    290                 295                 300                 


Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu Asp 
305                 310                 315                 320 


Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly Ile 
                325                 330                 335     


Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln Gly 
            340                 345                 350         


His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys Ala 
        355                 360                 365             


Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr Ser 
    370                 375                 380                 


Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His Val 
385                 390                 395                 400 


Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu Ser 
                405                 410                 415     


Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn Asn 
            420                 425                 430         


Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro Leu 
        435                 440                 445             


Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met Ala 
    450                 455                 460                 


Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser Thr 
465                 470                 475                 480 


Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg Cys 
                485                 490                 495     


<210> 5808
<211> 105
<212> PRT
<213> Homo sapiens

<400> 5808
Met Ala Leu Arg Tyr Pro Met Ala Val Gly Leu Asn Lys Gly His Lys 
1               5                   10                  15      


Val Thr Lys Asn Val Ser Lys Pro Arg His Ser Arg Arg Arg Gly Arg 
            20                  25                  30          


Leu Thr Lys His Thr Lys Phe Val Arg Asp Met Ile Arg Glu Val Cys 
        35                  40                  45              


Gly Phe Ala Pro Tyr Glu Arg Arg Ala Met Glu Leu Leu Lys Val Ser 
    50                  55                  60                  


Lys Asp Lys Arg Ala Leu Lys Phe Ile Lys Lys Arg Val Gly Thr His 
65                  70                  75                  80  


Ile Arg Ala Lys Arg Lys Arg Glu Glu Leu Ser Asn Val Leu Ala Ala 
                85                  90                  95      


Met Arg Lys Ala Ala Ala Lys Lys Asp 
            100                 105 


<210> 5809
<211> 1239
<212> PRT
<213> Homo sapiens

<400> 5809
Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Ile Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp 
        115                 120                 125             


Trp Ile Ala Tyr Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ile His His Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Tyr Arg Ser Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys 
            260                 265                 270         


Asn Tyr Met Gln Arg Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln 
                325                 330                 335     


Glu Gly Glu Pro Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu 
            340                 345                 350         


Arg Arg Asp Phe Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu 
        355                 360                 365             


Ala Leu Arg Arg Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln 
    370                 375                 380                 


Glu Glu Tyr Lys Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu 
385                 390                 395                 400 


Gln Gln Lys Glu Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu 
                405                 410                 415     


Arg Glu Ala Arg Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln 
            420                 425                 430         


Glu Glu Lys Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu 
        435                 440                 445             


Glu Glu Arg Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu 
    450                 455                 460                 


Gln Glu Tyr Ile Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu 
465                 470                 475                 480 


Val Leu Gln Gln Gln Leu Leu Gln Glu Gln Ala Met Leu Leu Glu Cys 
                485                 490                 495     


Arg Trp Arg Glu Met Glu Glu His Arg Gln Ala Glu Arg Leu Gln Arg 
            500                 505                 510         


Gln Leu Gln Gln Glu Gln Ala Tyr Leu Leu Ser Leu Gln His Asp His 
        515                 520                 525             


Arg Arg Pro His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln Gln 
    530                 535                 540                 


Glu Arg Ser Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr 
545                 550                 555                 560 


Glu Pro Ala Asp Arg Ala Arg Glu Val Glu Asp Arg Phe Arg Lys Thr 
                565                 570                 575     


Asn His Ser Ser Pro Glu Ala Gln Ser Lys Gln Thr Gly Arg Val Leu 
            580                 585                 590         


Glu Pro Pro Val Pro Ser Arg Ser Glu Ser Phe Ser Asn Gly Asn Ser 
        595                 600                 605             


Glu Ser Val His Pro Ala Leu Gln Arg Pro Ala Glu Pro Gln Val Pro 
    610                 615                 620                 


Val Arg Thr Thr Ser Arg Ser Pro Val Leu Ser Arg Arg Asp Ser Pro 
625                 630                 635                 640 


Leu Gln Gly Ser Gly Gln Gln Asn Ser Gln Ala Gly Gln Arg Asn Ser 
                645                 650                 655     


Thr Ser Ile Glu Pro Arg Leu Leu Trp Glu Arg Val Glu Lys Leu Val 
            660                 665                 670         


Pro Arg Pro Gly Ser Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly Ser 
        675                 680                 685             


Gln Pro Gly Ser His Pro Gly Ser Gln Ser Gly Ser Gly Glu Arg Phe 
    690                 695                 700                 


Arg Val Arg Ser Ser Ser Lys Ser Glu Gly Ser Pro Ser Gln Arg Leu 
705                 710                 715                 720 


Glu Asn Ala Val Lys Lys Pro Glu Asp Lys Lys Glu Val Phe Arg Pro 
                725                 730                 735     


Leu Lys Pro Ala Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val 
            740                 745                 750         


Glu Asp Val Arg Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser 
        755                 760                 765             


Glu Glu Ser Gly Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gln Glu 
    770                 775                 780                 


Gly Ala Asp Glu Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser 
785                 790                 795                 800 


Ser Leu Asn Leu Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met Ile 
                805                 810                 815     


Val His Asp Asp Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu 
            820                 825                 830         


Gly Thr Leu Ile Val Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu Gln 
        835                 840                 845             


Lys His Lys Ser Ser Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg Leu 
    850                 855                 860                 


Leu Gln Ile Ser Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly 
865                 870                 875                 880 


Phe Ser Cys Asp Gly Met Arg Pro Glu Ala Ile Arg Gln Asp Pro Thr 
                885                 890                 895     


Arg Lys Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gln 
            900                 905                 910         


Ser Asp Thr Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu 
        915                 920                 925             


Ile Leu Cys Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu 
    930                 935                 940                 


Ser Gly Leu Met Leu Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Pro 
945                 950                 955                 960 


Leu Ile Asn Arg Arg Arg Phe Gln Gln Met Asp Val Leu Glu Gly Leu 
                965                 970                 975     


Asn Val Leu Val Thr Ile Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr 
            980                 985                 990         


Tyr Leu Ser Trp Leu Arg Asn Lys  Ile Leu His Asn Asp  Pro Glu Val 
        995                 1000                 1005             


Glu Lys  Lys Gln Gly Trp Thr  Thr Val Gly Asp Leu  Glu Gly Cys 
    1010                 1015                 1020             


Val His  Tyr Lys Val Val Lys  Tyr Glu Arg Ile Lys  Phe Leu Val 
    1025                 1030                 1035             


Ile Ala  Leu Lys Ser Ser Val  Glu Val Tyr Ala Trp  Ala Pro Lys 
    1040                 1045                 1050             


Pro Tyr  His Lys Phe Met Ala  Phe Lys Ser Phe Gly  Glu Leu Val 
    1055                 1060                 1065             


His Lys  Pro Leu Leu Val Asp  Leu Thr Val Glu Glu  Gly Gln Arg 
    1070                 1075                 1080             


Leu Lys  Val Ile Tyr Gly Ser  Cys Ala Gly Phe His  Ala Val Asp 
    1085                 1090                 1095             


Val Asp  Ser Gly Ser Val Tyr  Asp Ile Tyr Leu Pro  Thr His Ile 
    1100                 1105                 1110             


Gln Cys  Ser Ile Lys Pro His  Ala Ile Ile Ile Leu  Pro Asn Thr 
    1115                 1120                 1125             


Asp Gly  Met Glu Leu Leu Val  Cys Tyr Glu Asp Glu  Gly Val Tyr 
    1130                 1135                 1140             


Val Asn  Thr Tyr Gly Arg Ile  Thr Lys Asp Val Val  Leu Gln Trp 
    1145                 1150                 1155             


Gly Glu  Met Pro Thr Ser Val  Ala Tyr Ile Arg Ser  Asn Gln Thr 
    1160                 1165                 1170             


Met Gly  Trp Gly Glu Lys Ala  Ile Glu Ile Arg Ser  Val Glu Thr 
    1175                 1180                 1185             


Gly His  Leu Asp Gly Val Phe  Met His Lys Arg Ala  Gln Arg Leu 
    1190                 1195                 1200             


Lys Phe  Leu Cys Glu Arg Asn  Asp Lys Val Phe Phe  Ala Ser Val 
    1205                 1210                 1215             


Arg Ser  Gly Gly Ser Ser Gln  Val Tyr Phe Met Thr  Leu Gly Arg 
    1220                 1225                 1230             


Thr Ser  Leu Leu Ser Trp 
    1235                 


<210> 5810
<211> 948
<212> PRT
<213> Homo sapiens

<400> 5810
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Ile Gly Gln Val Lys Gln Glu Leu Ser 
        435                 440                 445             


Arg Lys Asp Thr Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu 
    450                 455                 460                 


Thr Asn Gln Phe Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Thr Ala Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val 
                485                 490                 495     


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
            500                 505                 510         


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
        515                 520                 525             


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
    530                 535                 540                 


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
545                 550                 555                 560 


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
                565                 570                 575     


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
            580                 585                 590         


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
        595                 600                 605             


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
    610                 615                 620                 


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
625                 630                 635                 640 


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
                645                 650                 655     


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
            660                 665                 670         


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
        675                 680                 685             


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
    690                 695                 700                 


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
705                 710                 715                 720 


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
                725                 730                 735     


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
            740                 745                 750         


Glu Leu Glu Ser Leu Thr Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
        755                 760                 765             


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
    770                 775                 780                 


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
785                 790                 795                 800 


Ser Gln Gln Leu Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val 
                805                 810                 815     


Lys Gln Glu Leu Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln 
            820                 825                 830         


Ser Leu Ala Glu Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg 
        835                 840                 845             


Arg Lys His Leu Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu 
    850                 855                 860                 


Ala Ala Ile Ser Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser 
865                 870                 875                 880 


Ser Ser Lys Lys Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu 
                885                 890                 895     


Lys Asp Arg Leu Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met 
            900                 905                 910         


Lys Leu Met Ala Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His 
        915                 920                 925             


Ser Asn Gln Thr Asn His Lys Pro Ser Pro Asp Gln Asp Glu Glu Glu 
    930                 935                 940                 


Gly Ile Trp Ala 
945             


<210> 5811
<211> 910
<212> PRT
<213> Homo sapiens

<400> 5811
Met Ala Ala Thr Val Glu Gly Pro Glu Leu Glu Ala Ala Ala Ala Ala 
1               5                   10                  15      


Gly Asp Ala Ser Glu Asp Ser Asp Ala Gly Ser Arg Ala Leu Pro Phe 
            20                  25                  30          


Leu Gly Gly Asn Arg Leu Ser Leu Asp Leu Tyr Pro Gly Gly Cys Gln 
        35                  40                  45              


Gln Leu Leu His Leu Cys Val Gln Gln Pro Leu Gln Leu Leu Gln Val 
    50                  55                  60                  


Glu Phe Leu Arg Leu Ser Thr His Glu Asp Pro Gln Leu Leu Glu Ala 
65                  70                  75                  80  


Thr Leu Ala Gln Leu Pro Gln Ser Leu Ser Cys Leu Arg Ser Leu Val 
                85                  90                  95      


Leu Lys Gly Gly Gln Arg Arg Asp Thr Leu Gly Ala Cys Leu Arg Gly 
            100                 105                 110         


Ala Leu Thr Asn Leu Pro Ala Gly Leu Ser Gly Leu Ala His Leu Ala 
        115                 120                 125             


His Leu Asp Leu Ser Phe Asn Ser Leu Glu Thr Leu Pro Ala Cys Val 
    130                 135                 140                 


Leu Gln Met Arg Gly Leu Gly Ala Leu Leu Leu Ser His Asn Cys Leu 
145                 150                 155                 160 


Ser Glu Leu Pro Glu Ala Leu Gly Ala Leu Pro Ala Leu Thr Phe Leu 
                165                 170                 175     


Thr Val Thr His Asn Arg Leu Gln Thr Leu Pro Pro Ala Leu Gly Ala 
            180                 185                 190         


Leu Ser Thr Leu Gln Arg Leu Asp Leu Ser Gln Asn Leu Leu Asp Thr 
        195                 200                 205             


Leu Pro Pro Glu Ile Gly Gly Leu Gly Ser Leu Leu Glu Leu Asn Leu 
    210                 215                 220                 


Ala Ser Asn Arg Leu Gln Ser Leu Pro Ala Ser Leu Ala Gly Leu Arg 
225                 230                 235                 240 


Ser Leu Arg Leu Leu Val Leu His Ser Asn Leu Leu Ala Ser Val Pro 
                245                 250                 255     


Ala Asp Leu Ala Arg Leu Pro Leu Leu Thr Arg Leu Asp Leu Arg Asp 
            260                 265                 270         


Asn Gln Leu Arg Asp Leu Pro Pro Glu Leu Leu Asp Ala Pro Phe Val 
        275                 280                 285             


Arg Leu Gln Gly Asn Pro Leu Gly Glu Ala Ser Pro Asp Ala Pro Ser 
    290                 295                 300                 


Ser Pro Val Ala Ala Leu Ile Pro Glu Met Pro Arg Leu Phe Leu Thr 
305                 310                 315                 320 


Ser Asp Leu Asp Ser Phe Pro Val Thr Pro Gln Gly Cys Ser Val Thr 
                325                 330                 335     


Leu Ala Cys Gly Val Arg Leu Gln Phe Pro Ala Gly Ala Thr Ala Thr 
            340                 345                 350         


Pro Ile Thr Ile Arg Tyr Arg Leu Leu Leu Pro Glu Pro Gly Leu Val 
        355                 360                 365             


Pro Leu Gly Pro His Asp Ala Leu Leu Ser His Val Leu Glu Leu Gln 
    370                 375                 380                 


Pro His Gly Val Ala Phe Gln Gln Asp Val Gly Leu Trp Leu Leu Phe 
385                 390                 395                 400 


Thr Pro Pro Gln Ala Arg Arg Cys Arg Glu Val Val Val Arg Thr Arg 
                405                 410                 415     


Asn Asp Asn Ser Trp Gly Asp Leu Glu Thr Tyr Leu Glu Glu Glu Ala 
            420                 425                 430         


Pro Gln Arg Leu Trp Ala His Cys Gln Val Pro His Phe Ser Trp Phe 
        435                 440                 445             


Leu Val Val Ser Arg Pro Val Ser Asn Ala Cys Leu Val Pro Pro Glu 
    450                 455                 460                 


Gly Thr Leu Leu Cys Ser Ser Gly His Pro Gly Val Lys Val Ile Phe 
465                 470                 475                 480 


Pro Pro Gly Ala Thr Glu Glu Pro Arg Arg Val Ser Met Gln Val Val 
                485                 490                 495     


Arg Met Ala Gly Arg Glu Leu Gln Ala Leu Leu Gly Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ser Pro Leu Leu Cys Leu Ser Gln Ser Gly Pro Pro Ser Phe 
        515                 520                 525             


Leu Gln Pro Val Thr Val Gln Leu Pro Leu Pro Ser Gly Ile Thr Gly 
    530                 535                 540                 


Leu Ser Leu Asp Arg Ser Arg Leu His Leu Leu Tyr Trp Ala Pro Pro 
545                 550                 555                 560 


Ala Ala Thr Trp Asp Asp Ile Thr Ala Gln Val Val Leu Glu Leu Thr 
                565                 570                 575     


His Leu Tyr Ala Arg Phe Gln Val Thr His Phe Ser Trp Tyr Trp Leu 
            580                 585                 590         


Trp Tyr Thr Thr Lys Asn Cys Val Gly Gly Leu Ala Arg Lys Ala Trp 
        595                 600                 605             


Glu Arg Leu Arg Leu His Arg Val Asn Leu Ile Ala Leu Gln Arg Arg 
    610                 615                 620                 


Arg Asp Pro Glu Gln Val Leu Leu Gln Cys Leu Pro Arg Asn Lys Val 
625                 630                 635                 640 


Asp Ala Thr Leu Arg Arg Leu Leu Glu Arg Tyr Arg Gly Pro Glu Pro 
                645                 650                 655     


Ser Asp Thr Val Glu Met Phe Glu Gly Glu Glu Phe Phe Ala Ala Phe 
            660                 665                 670         


Glu Arg Gly Ile Asp Val Asp Ala Asp Arg Pro Asp Cys Val Glu Gly 
        675                 680                 685             


Arg Ile Cys Phe Val Phe Tyr Ser His Leu Lys Asn Val Lys Glu Val 
    690                 695                 700                 


Tyr Val Thr Thr Thr Leu Asp Arg Glu Ala Gln Ala Val Arg Gly Gln 
705                 710                 715                 720 


Val Ser Phe Tyr Arg Gly Ala Val Pro Val Arg Val Pro Glu Glu Ala 
                725                 730                 735     


Glu Ala Ala Arg Gln Arg Lys Gly Ala Asp Ala Leu Trp Met Ala Thr 
            740                 745                 750         


Leu Pro Ile Lys Leu Pro Arg Leu Arg Gly Ser Glu Gly Pro Arg Arg 
        755                 760                 765             


Gly Ala Gly Leu Ser Leu Ala Pro Leu Asn Leu Gly Asp Ala Glu Thr 
    770                 775                 780                 


Gly Phe Leu Thr Gln Ser Asn Leu Leu Ser Val Ala Gly Arg Leu Gly 
785                 790                 795                 800 


Leu Asp Trp Pro Ala Val Ala Leu His Leu Gly Val Ser Tyr Arg Glu 
                805                 810                 815     


Val Gln Arg Ile Arg His Glu Phe Arg Asp Asp Leu Asp Glu Gln Ile 
            820                 825                 830         


Arg His Met Leu Phe Ser Trp Ala Glu Arg Gln Ala Gly Gln Pro Gly 
        835                 840                 845             


Ala Val Gly Leu Leu Val Gln Ala Leu Glu Gln Ser Asp Arg Gln Asp 
    850                 855                 860                 


Val Ala Glu Glu Val Arg Ala Val Leu Glu Leu Gly Arg Arg Lys Tyr 
865                 870                 875                 880 


Gln Asp Ser Ile Arg Arg Met Gly Leu Ala Pro Lys Asp Pro Ala Leu 
                885                 890                 895     


Pro Gly Ser Ser Ala Pro Gln Pro Pro Glu Pro Ala Gln Ala 
            900                 905                 910 


<210> 5812
<211> 986
<212> PRT
<213> Homo sapiens

<400> 5812
Met Ser Gln Trp Thr Pro Glu Tyr Asn Glu Leu Tyr Thr Leu Lys Val 
1               5                   10                  15      


Asp Met Lys Ser Glu Ile Pro Ser Asp Ala Pro Lys Thr Gln Glu Ser 
            20                  25                  30          


Leu Lys Gly Ile Leu Leu His Pro Glu Pro Ile Gly Ala Ala Lys Ser 
        35                  40                  45              


Phe Pro Ala Gly Val Glu Met Ile Asn Ser Lys Val Gly Asn Glu Phe 
    50                  55                  60                  


Ser His Leu Cys Asp Asp Ser Gln Lys Gln Glu Lys Glu Met Asn Gly 
65                  70                  75                  80  


Asn Gln Gln Glu Gln Glu Lys Ser Leu Val Val Arg Lys Lys Arg Lys 
                85                  90                  95      


Ser Gln Gln Ala Gly Pro Ser Tyr Val Gln Asn Cys Val Lys Glu Asn 
            100                 105                 110         


Gln Gly Ile Leu Gly Leu Arg Gln His Leu Gly Thr Pro Ser Asp Glu 
        115                 120                 125             


Asp Asn Asp Ser Ser Phe Ser Asp Cys Leu Ser Ser Pro Ser Ser Ser 
    130                 135                 140                 


Leu His Phe Gly Asp Ser Asp Thr Val Thr Ser Asp Glu Asp Lys Glu 
145                 150                 155                 160 


Val Ser Val Arg His Ser Gln Thr Ile Leu Asn Ala Lys Ser Arg Ser 
                165                 170                 175     


His Ser Ala Arg Ser His Lys Trp Pro Arg Thr Glu Thr Glu Ser Val 
            180                 185                 190         


Ser Gly Leu Leu Met Lys Arg Pro Cys Leu His Gly Ser Ser Leu Arg 
        195                 200                 205             


Arg Leu Pro Cys Arg Lys Arg Phe Val Lys Asn Asn Ser Ser Gln Arg 
    210                 215                 220                 


Thr Gln Lys Gln Lys Glu Arg Ile Leu Met Gln Arg Lys Lys Arg Glu 
225                 230                 235                 240 


Val Leu Ala Arg Arg Lys Tyr Ala Leu Leu Pro Ser Ser Ser Ser Ser 
                245                 250                 255     


Ser Glu Asn Asp Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Thr Glu 
            260                 265                 270         


Gly Glu Glu Asp Leu Phe Val Ser Ala Ser Glu Asn His Gln Asn Asn 
        275                 280                 285             


Pro Ala Val Pro Ser Gly Ser Ile Asp Glu Asp Val Val Val Ile Glu 
    290                 295                 300                 


Ala Ser Ser Thr Pro Gln Val Thr Ala Asn Glu Glu Ile Asn Val Thr 
305                 310                 315                 320 


Ser Thr Asp Ser Glu Val Glu Ile Val Thr Val Gly Glu Ser Tyr Arg 
                325                 330                 335     


Ser Arg Ser Thr Leu Gly His Ser Arg Ser His Trp Ser Gln Gly Ser 
            340                 345                 350         


Ser Ser His Ala Ser Arg Pro Gln Glu Pro Arg Asn Arg Ser Arg Ile 
        355                 360                 365             


Ser Thr Val Ile Gln Pro Leu Arg Gln Asn Ala Ala Glu Val Val Asp 
    370                 375                 380                 


Leu Thr Val Asp Glu Asp Glu Pro Thr Val Val Pro Thr Thr Ser Ala 
385                 390                 395                 400 


Arg Met Glu Ser Gln Ala Thr Ser Ala Ser Ile Asn Asn Ser Asn Pro 
                405                 410                 415     


Ser Thr Ser Glu Gln Ala Ser Asp Thr Ala Ser Ala Val Thr Ser Ser 
            420                 425                 430         


Gln Pro Ser Thr Val Ser Glu Thr Ser Ala Thr Leu Thr Ser Asn Ser 
        435                 440                 445             


Thr Thr Gly Thr Ser Ile Gly Asp Asp Ser Arg Arg Thr Thr Ser Ser 
    450                 455                 460                 


Ala Val Thr Glu Thr Gly Pro Pro Ala Met Pro Arg Leu Pro Ser Cys 
465                 470                 475                 480 


Cys Pro Gln His Ser Pro Cys Gly Gly Ser Ser Gln Asn His His Ala 
                485                 490                 495     


Leu Gly His Pro His Thr Ser Cys Phe Gln Gln His Gly His His Phe 
            500                 505                 510         


Gln His His His His His His His Thr Pro His Pro Ala Val Pro Val 
        515                 520                 525             


Ser Pro Ser Phe Ser Asp Pro Ala Cys Pro Val Glu Arg Pro Pro Gln 
    530                 535                 540                 


Val Gln Ala Pro Cys Gly Ala Asn Ser Ser Ser Gly Thr Ser Tyr His 
545                 550                 555                 560 


Glu Gln Gln Ala Leu Pro Val Asp Leu Ser Asn Ser Gly Ile Arg Ser 
                565                 570                 575     


His Gly Ser Gly Ser Phe His Gly Ala Ser Ala Phe Asp Pro Cys Cys 
            580                 585                 590         


Pro Val Ser Ser Ser Arg Ala Ala Ile Phe Gly His Gln Ala Ala Ala 
        595                 600                 605             


Ala Ala Pro Ser Gln Pro Leu Ser Ser Ile Asp Gly Tyr Gly Ser Ser 
    610                 615                 620                 


Met Val Ala Gln Pro Gln Pro Gln Pro Pro Pro Gln Pro Ser Leu Ser 
625                 630                 635                 640 


Ser Cys Arg His Tyr Met Pro Pro Pro Tyr Ala Ser Leu Thr Arg Pro 
                645                 650                 655     


Leu His His Gln Ala Ser Ala Cys Pro His Ser His Gly Asn Pro Pro 
            660                 665                 670         


Pro Gln Thr Gln Pro Pro Pro Gln Val Asp Tyr Val Ile Pro His Pro 
        675                 680                 685             


Val His Ala Phe His Ser Gln Ile Ser Ser His Ala Thr Ser His Pro 
    690                 695                 700                 


Val Ala Pro Pro Pro Pro Thr His Leu Ala Ser Thr Ala Ala Pro Ile 
705                 710                 715                 720 


Pro Gln His Leu Pro Pro Thr His Gln Pro Ile Ser His His Ile Pro 
                725                 730                 735     


Ala Thr Ala Pro Pro Ala Gln Arg Leu His Pro His Glu Val Met Gln 
            740                 745                 750         


Arg Met Glu Val Gln Arg Arg Arg Met Met Gln His Pro Thr Arg Ala 
        755                 760                 765             


His Glu Arg Pro Pro Pro His Pro His Arg Met His Pro Asn Tyr Gly 
    770                 775                 780                 


His Gly His His Ile His Val Pro Gln Thr Met Ser Ser His Pro Arg 
785                 790                 795                 800 


Gln Ala Pro Glu Arg Ser Ala Trp Glu Leu Gly Ile Glu Ala Gly Val 
                805                 810                 815     


Thr Ala Ala Thr Tyr Thr Pro Gly Ala Leu His Pro His Leu Ala His 
            820                 825                 830         


Tyr His Ala Pro Pro Arg Leu His His Leu Gln Leu Gly Ala Leu Pro 
        835                 840                 845             


Leu Met Val Pro Asp Met Ala Gly Tyr Pro His Ile Arg Tyr Ile Ser 
    850                 855                 860                 


Ser Gly Leu Asp Gly Thr Ser Phe Arg Gly Pro Phe Arg Gly Asn Phe 
865                 870                 875                 880 


Glu Glu Leu Ile His Leu Glu Glu Arg Leu Gly Asn Val Asn Arg Gly 
                885                 890                 895     


Ala Ser Gln Gly Thr Ile Glu Arg Cys Thr Tyr Pro His Lys Tyr Lys 
            900                 905                 910         


Lys Arg Lys Leu His Cys Lys Gln Asp Gly Glu Glu Gly Thr Glu Glu 
        915                 920                 925             


Asp Thr Glu Glu Lys Cys Thr Ile Cys Leu Ser Ile Leu Glu Glu Gly 
    930                 935                 940                 


Glu Asp Val Arg Arg Leu Pro Cys Met His Leu Phe His Gln Val Cys 
945                 950                 955                 960 


Val Asp Gln Trp Leu Ile Thr Asn Lys Lys Cys Pro Ile Cys Arg Val 
                965                 970                 975     


Asp Ile Glu Ala Gln Leu Pro Ser Glu Ser 
            980                 985     


<210> 5813
<211> 123
<212> PRT
<213> Homo sapiens

<400> 5813
Met Ala Lys Ile Lys Ala Arg Asp Leu Arg Gly Lys Lys Lys Glu Glu 
1               5                   10                  15      


Leu Leu Lys Gln Leu Asp Asp Leu Lys Val Glu Leu Ser Gln Leu Arg 
            20                  25                  30          


Val Ala Lys Val Thr Gly Gly Ala Ala Ser Lys Leu Ser Lys Ile Arg 
        35                  40                  45              


Val Val Arg Lys Ser Ile Ala Arg Val Leu Thr Val Ile Asn Gln Thr 
    50                  55                  60                  


Gln Lys Glu Asn Leu Arg Lys Phe Tyr Lys Gly Lys Lys Tyr Lys Pro 
65                  70                  75                  80  


Leu Asp Leu Arg Pro Lys Lys Thr Arg Ala Met Arg Arg Arg Leu Asn 
                85                  90                  95      


Lys His Glu Glu Asn Leu Lys Thr Lys Lys Gln Gln Arg Lys Glu Arg 
            100                 105                 110         


Leu Tyr Pro Leu Arg Lys Tyr Ala Val Lys Ala 
        115                 120             


<210> 5814
<211> 544
<212> PRT
<213> Homo sapiens

<400> 5814
Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr Gly Ser Val Glu 
1               5                   10                  15      


Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln Glu Ile Ala Arg 
            20                  25                  30          


Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg Asn Val Lys Tyr 
        35                  40                  45              


Tyr Gln Gly Ile Arg Ala Ala Val Ser Arg Val Lys Asp Arg Gly Gln 
    50                  55                  60                  


Lys Ala Leu Val Leu Asp Ile Gly Thr Gly Thr Gly Leu Leu Ser Met 
65                  70                  75                  80  


Met Ala Val Thr Ala Gly Ala Asp Phe Cys Tyr Ala Ile Glu Glu Asn 
                85                  90                  95      


Cys Glu Ala Val Pro His Arg Ala Thr Val Tyr Ala Gln Leu Val Glu 
            100                 105                 110         


Ser Gly Arg Met Trp Ser Trp Asn Lys Leu Phe Pro Ile His Val Gln 
        115                 120                 125             


Thr Ser Leu Gly Glu Gln Val Ile Val Pro Pro Val Asp Val Glu Ser 
    130                 135                 140                 


Cys Pro Gly Ala Pro Ser Val Cys Asp Ile Gln Leu Asn Gln Val Ser 
145                 150                 155                 160 


Pro Ala Asp Phe Thr Val Leu Ser Asp Val Leu Pro Met Phe Ser Ile 
                165                 170                 175     


Asp Phe Ser Lys Gln Val Ser Ser Ser Ala Ala Cys His Ser Arg Arg 
            180                 185                 190         


Phe Glu Pro Leu Thr Ser Gly Arg Ala Gln Val Val Leu Ser Trp Trp 
        195                 200                 205             


Asp Ile Glu Met Asp Pro Glu Gly Lys Ile Lys Cys Thr Met Ala Pro 
    210                 215                 220                 


Phe Trp Ala His Ser Asp Pro Glu Glu Met Gln Trp Arg Asp His Trp 
225                 230                 235                 240 


Met Gln Cys Val Tyr Phe Leu Pro Gln Glu Glu Pro Val Val Gln Gly 
                245                 250                 255     


Ser Ala Leu Tyr Leu Val Ala His His Asp Asp Tyr Cys Val Trp Tyr 
            260                 265                 270         


Ser Leu Gln Arg Thr Ser Pro Glu Lys Asn Glu Arg Val Arg Gln Met 
        275                 280                 285             


Arg Pro Val Cys Asp Cys Gln Ala His Leu Leu Trp Asn Arg Pro Arg 
    290                 295                 300                 


Phe Gly Glu Ile Asn Asp Gln Asp Arg Thr Asp Arg Tyr Val Gln Ala 
305                 310                 315                 320 


Leu Arg Thr Val Ser Leu Leu Leu Gly Glu Pro Phe Phe Thr Thr Ser 
                325                 330                 335     


Leu Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val Arg Thr Ala Val 
            340                 345                 350         


Asp Gln His Leu Gly Pro Gly Ala Met Val Met Pro Gln Ala Ala Ser 
        355                 360                 365             


Leu His Ala Val Val Val Glu Phe Arg Asp Leu Trp Arg Ile Arg Ser 
    370                 375                 380                 


Pro Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile Met Asp Asp Met 
385                 390                 395                 400 


Ile Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu Ala Glu Pro His 
                405                 410                 415     


Pro Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu Pro Trp Gln Ile 
            420                 425                 430         


Leu Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln Pro Leu Cys Ala 
        435                 440                 445             


Glu Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser His Ala Ala Val 
    450                 455                 460                 


Leu Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr Leu Ser Thr Gly 
465                 470                 475                 480 


Leu Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys Trp Asn Pro His 
                485                 490                 495     


Cys Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro Asp Pro Arg Ala 
            500                 505                 510         


Leu Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val Glu Phe His Pro 
        515                 520                 525             


Asp Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala Asp Thr Pro Asp 
    530                 535                 540                 


<210> 5815
<211> 376
<212> PRT
<213> Homo sapiens

<400> 5815
Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 
1               5                   10                  15      


Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 
            20                  25                  30          


Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 
        35                  40                  45              


Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 
    50                  55                  60                  


Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 
65                  70                  75                  80  


Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 
                85                  90                  95      


Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 
            100                 105                 110         


Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 
        115                 120                 125             


Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 
    130                 135                 140                 


Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 
145                 150                 155                 160 


Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 
                165                 170                 175     


Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 
            180                 185                 190         


Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 
        195                 200                 205             


Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 
    210                 215                 220                 


Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 
225                 230                 235                 240 


Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 
                245                 250                 255     


Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 
            260                 265                 270         


Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 
        275                 280                 285             


Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 
    290                 295                 300                 


Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 
305                 310                 315                 320 


Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 
                325                 330                 335     


Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Tyr Arg 
            340                 345                 350         


Ile Met Lys Arg His Leu Arg Leu Ile His Pro Thr Lys Leu Tyr Lys 
        355                 360                 365             


Leu Met Leu Arg Arg Phe Gly Met 
    370                 375     


<210> 5816
<211> 1406
<212> PRT
<213> Homo sapiens

<400> 5816
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His Val Arg Thr Arg 
            820                 825                 830         


Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser Val Phe 
        835                 840                 845             


Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala Gln Trp Gln Arg 
    850                 855                 860                 


Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn Tyr Met Thr Gln 
865                 870                 875                 880 


Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp Pro Leu Ser Glu 
                885                 890                 895     


Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Val Lys Gly Val 
            900                 905                 910         


Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe Arg Pro Ala Ser 
        915                 920                 925             


Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser Met Glu Asn Leu 
    930                 935                 940                 


Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala Leu Gln Thr Ser 
945                 950                 955                 960 


Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg Ser Pro Leu Ile 
                965                 970                 975     


Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser Glu Thr Ser Ser 
            980                 985                 990         


Ser Arg Pro Gly Gly Tyr Arg Leu  Phe Ser Ser Ser Arg  Pro Pro Thr 
        995                 1000                 1005             


Glu Met  Lys Gln Ser Gly Leu  Gly Phe Glu Gly Cys  Ser Met Val 
    1010                 1015                 1020             


Pro Thr  Ile Tyr Pro Leu Glu  Thr Leu His Asn Ala  Leu Ser Leu 
    1025                 1030                 1035             


Arg Gln  Val Ser Glu Phe Leu  Ser Arg Val Cys Gln  Arg His Thr 
    1040                 1045                 1050             


Asp Ala  Gln Ala Gln Ala Ser  Ala Ala Leu Phe Asp  Ser Met His 
    1055                 1060                 1065             


Ser Ser  Gln Ala Ser Asp Asn  Pro Phe Ser Pro Pro  Arg Thr Leu 
    1070                 1075                 1080             


His Ser  Pro Pro Leu Gln Leu  Gln Gln Arg Ser Glu  Lys Pro Pro 
    1085                 1090                 1095             


Trp Leu  Glu Thr Arg Phe Cys  His Val Gly Gln Ala  Gly Leu Glu 
    1100                 1105                 1110             


Leu Leu  Thr Ser Ser Asp Leu  Pro Ala Ser Ala Ser  Gln Ser Ala 
    1115                 1120                 1125             


Gly Ile  Thr Gly Val Ser His  Arg Thr Gln Pro Asp  Ser Ser Gly 
    1130                 1135                 1140             


Pro Ser  Ser Thr Val Ser Ser  Ala Gly Pro Ser Ser  Pro Thr Thr 
    1145                 1150                 1155             


Val Asp  Gly Asn Ser Gln Phe  Gly Phe Ser Asp Gln  Pro Ser Leu 
    1160                 1165                 1170             


Asn Ser  His Val Ala Glu Glu  His Gln Gly Leu Gly  Leu Leu Gln 
    1175                 1180                 1185             


Glu Thr  Pro Gly Ser Gly Ala  Gln Glu Leu Ser Ile  Glu Gly Glu 
    1190                 1195                 1200             


Gln Glu  Leu Phe Glu Pro Asn  Gln Ser Pro Gln Val  Pro Pro Met 
    1205                 1210                 1215             


Glu Thr  Ser Gln Pro Tyr Glu  Glu Val Ser Gln Pro  Cys Gln Glu 
    1220                 1225                 1230             


Val Pro  Asp Ile Ser Gln Pro  Cys Gln Asp Ile Ser  Glu Ala Leu 
    1235                 1240                 1245             


Ser Gln  Pro Cys Gln Lys Val  Pro Asp Ile Ser Gln  Gln Cys Gln 
    1250                 1255                 1260             


Glu Asn  His Asp Asn Gly Asn  His Thr Cys Gln Glu  Val Pro His 
    1265                 1270                 1275             


Ile Ser  Gln Pro Cys Gln Lys  Ser Ser Gln Leu Cys  Gln Lys Val 
    1280                 1285                 1290             


Ser Glu  Glu Val Cys Gln Leu  Cys Leu Glu Asn Ser  Glu Glu Val 
    1295                 1300                 1305             


Ser Gln  Pro Cys Gln Gly Val  Ser Val Glu Val Gly  Lys Leu Val 
    1310                 1315                 1320             


His Lys  Phe His Val Gly Val  Gly Ser Leu Val Gln  Glu Thr Leu 
    1325                 1330                 1335             


Val Glu  Val Gly Ser Pro Ala  Glu Glu Ile Pro Glu  Glu Val Ile 
    1340                 1345                 1350             


Gln Pro  Tyr Gln Glu Phe Ser  Val Glu Val Gly Arg  Leu Ala Gln 
    1355                 1360                 1365             


Glu Thr  Ser Ala Ile Asn Leu  Leu Ser Gln Gly Ile  Pro Glu Ile 
    1370                 1375                 1380             


Asp Lys  Pro Ser Gln Glu Phe  Pro Glu Glu Ile Asp  Leu Gln Ala 
    1385                 1390                 1395             


Gln Glu  Val Pro Glu Glu Ile  Asn 
    1400                 1405     


<210> 5817
<211> 445
<212> PRT
<213> Homo sapiens

<400> 5817
Met Val Leu Glu Gly Asn Pro Glu Val Gly Ser Pro Arg Thr Ser Asp 
1               5                   10                  15      


Leu Gln His Arg Gly Asn Lys Gly Ser Cys Val Leu Ser Ser Pro Gly 
            20                  25                  30          


Glu Asp Ala Gln Pro Gly Glu Glu Pro Ile Lys Tyr Gly Glu Leu Ile 
        35                  40                  45              


Val Leu Gly Tyr Asn Gly Cys Leu Ala Ser Gly Asp Lys Gly Arg Arg 
    50                  55                  60                  


Arg Ser Arg Leu Ala Leu Ser Arg Arg Ser His Ala Asn Gly Val Lys 
65                  70                  75                  80  


Pro Asp Val Met His His Ile Ser Thr Pro Leu Val Ser Lys Ala Leu 
                85                  90                  95      


Ser Asn Arg Gly Gln His Ser Ile Ser Tyr Thr Leu Ser Arg Ser His 
            100                 105                 110         


Ser Val Ile Val Glu Tyr Thr His Asp Ser Asp Thr Asp Met Phe Gln 
        115                 120                 125             


Ile Gly Arg Ser Thr Glu Asn Met Ile Asp Phe Val Val Thr Asp Thr 
    130                 135                 140                 


Ser Pro Gly Gly Gly Ala Ala Glu Gly Pro Ser Ala Gln Ser Thr Ile 
145                 150                 155                 160 


Ser Arg Tyr Ala Cys Arg Ile Leu Cys Asp Arg Arg Pro Pro Tyr Thr 
                165                 170                 175     


Ala Arg Ile Tyr Ala Ala Gly Phe Asp Ala Ser Ser Asn Ile Phe Leu 
            180                 185                 190         


Gly Glu Arg Ala Ala Lys Trp Arg Thr Pro Asp Gly Leu Met Asp Gly 
        195                 200                 205             


Leu Thr Thr Asn Gly Val Leu Val Met His Pro Ala Gly Gly Phe Ser 
    210                 215                 220                 


Glu Asp Ser Ala Pro Gly Val Trp Arg Glu Ile Ser Val Cys Gly Asn 
225                 230                 235                 240 


Val Tyr Thr Leu Arg Asp Ser Arg Ser Ala Gln Gln Arg Gly Lys Leu 
                245                 250                 255     


Val Glu Asn Glu Ser Asn Val Leu Gln Asp Gly Ser Leu Ile Asp Leu 
            260                 265                 270         


Cys Gly Ala Thr Leu Leu Trp Arg Thr Pro Ala Gly Leu Leu Arg Ala 
        275                 280                 285             


Pro Thr Leu Lys Gln Leu Glu Ala Gln Arg Gln Glu Ala Asn Ala Ala 
    290                 295                 300                 


Arg Pro Gln Cys Pro Val Gly Leu Ser Thr Leu Ala Phe Pro Ser Pro 
305                 310                 315                 320 


Ala Arg Gly Arg Thr Ala Pro Asp Lys Gln Gln Pro Trp Val Tyr Val 
                325                 330                 335     


Arg Cys Gly His Val His Gly Tyr His Gly Trp Gly Cys Arg Arg Glu 
            340                 345                 350         


Arg Gly Pro Gln Glu Arg Glu Cys Pro Leu Cys Arg Leu Val Gly Pro 
        355                 360                 365             


Tyr Val Pro Leu Trp Leu Gly Gln Glu Ala Gly Leu Cys Leu Asp Pro 
    370                 375                 380                 


Gly Pro Pro Ser His Ala Phe Ala Pro Cys Gly His Val Cys Ser Glu 
385                 390                 395                 400 


Lys Thr Ala Arg Tyr Trp Ala Gln Thr Pro Leu Pro His Gly Thr His 
                405                 410                 415     


Ala Phe His Ala Ala Cys Pro Phe Cys Gly Ala Trp Leu Thr Gly Glu 
            420                 425                 430         


His Gly Cys Val Arg Leu Ile Phe Gln Gly Pro Leu Asp 
        435                 440                 445 


<210> 5818
<211> 649
<212> PRT
<213> Homo sapiens

<400> 5818
Met Gly Thr Ala Leu Val Tyr His Glu Asp Met Thr Ala Thr Arg Leu 
1               5                   10                  15      


Leu Trp Asp Asp Pro Glu Cys Glu Ile Glu Arg Pro Glu Arg Leu Thr 
            20                  25                  30          


Ala Ala Leu Asp Arg Leu Arg Gln Arg Gly Leu Glu Gln Arg Cys Leu 
        35                  40                  45              


Arg Leu Ser Ala Arg Glu Ala Ser Glu Glu Glu Leu Gly Leu Val His 
    50                  55                  60                  


Ser Pro Glu Tyr Val Ser Leu Val Arg Glu Thr Gln Val Leu Gly Lys 
65                  70                  75                  80  


Glu Glu Leu Gln Ala Leu Ser Gly Gln Phe Asp Ala Ile Tyr Phe His 
                85                  90                  95      


Pro Ser Thr Phe His Cys Ala Arg Leu Ala Ala Gly Ala Gly Leu Gln 
            100                 105                 110         


Leu Val Asp Ala Val Leu Thr Gly Ala Val Gln Asn Gly Leu Ala Leu 
        115                 120                 125             


Val Arg Pro Pro Gly His His Gly Gln Arg Ala Ala Ala Asn Gly Phe 
    130                 135                 140                 


Cys Val Phe Asn Asn Val Ala Ile Ala Ala Ala His Ala Lys Gln Lys 
145                 150                 155                 160 


His Gly Leu His Arg Ile Leu Val Val Asp Trp Asp Val His His Gly 
                165                 170                 175     


Gln Gly Ile Gln Tyr Leu Phe Glu Asp Asp Pro Ser Val Leu Tyr Phe 
            180                 185                 190         


Ser Trp His Arg Tyr Glu His Gly Arg Phe Trp Pro Phe Leu Arg Glu 
        195                 200                 205             


Ser Asp Ala Asp Ala Val Gly Arg Gly Gln Gly Leu Gly Phe Thr Val 
    210                 215                 220                 


Asn Leu Pro Trp Asn Gln Val Gly Met Gly Asn Ala Asp Tyr Val Ala 
225                 230                 235                 240 


Ala Phe Leu His Leu Leu Leu Pro Leu Ala Phe Glu Gly Gln Met Gln 
                245                 250                 255     


Ala Thr Pro Glu Cys Phe Ala His Leu Thr Gln Leu Leu Gln Val Leu 
            260                 265                 270         


Ala Gly Gly Arg Val Cys Ala Val Leu Glu Gly Gly Tyr His Leu Glu 
        275                 280                 285             


Ser Leu Ala Glu Ser Val Cys Met Thr Val Gln Thr Leu Leu Gly Asp 
    290                 295                 300                 


Pro Ala Pro Pro Leu Ser Gly Pro Met Ala Pro Cys Gln Ser Ala Leu 
305                 310                 315                 320 


Glu Ser Ile Gln Ser Ala Arg Ala Ala Gln Ala Pro His Trp Lys Ser 
                325                 330                 335     


Leu Gln Gln Gln Asp Val Thr Ala Val Pro Met Ser Pro Ser Ser His 
            340                 345                 350         


Ser Pro Glu Gly Arg Pro Pro Pro Leu Leu Pro Gly Gly Pro Val Cys 
        355                 360                 365             


Lys Ala Ala Ala Ser Ala Pro Ser Ser Leu Leu Asp Gln Pro Cys Leu 
    370                 375                 380                 


Cys Pro Ala Pro Ser Val Arg Thr Ala Val Ala Leu Thr Thr Pro Asp 
385                 390                 395                 400 


Ile Thr Leu Val Leu Pro Pro Asp Val Ile Gln Gln Glu Ala Ser Ala 
                405                 410                 415     


Leu Arg Glu Glu Thr Glu Ala Trp Ala Arg Pro His Glu Ser Leu Ala 
            420                 425                 430         


Arg Glu Glu Ala Leu Thr Ala Leu Gly Lys Leu Leu Tyr Leu Leu Asp 
        435                 440                 445             


Gly Met Leu Asp Gly Gln Val Asn Ser Gly Ile Ala Ala Thr Pro Ala 
    450                 455                 460                 


Ser Ala Ala Ala Ala Thr Leu Asp Val Ala Val Arg Arg Gly Leu Ser 
465                 470                 475                 480 


His Gly Ala Gln Arg Leu Leu Cys Val Ala Leu Gly Gln Leu Asp Arg 
                485                 490                 495     


Pro Pro Asp Leu Ala His Asp Gly Arg Ser Leu Trp Leu Asn Ile Arg 
            500                 505                 510         


Gly Lys Glu Ala Ala Ala Leu Ser Met Phe His Val Ser Thr Pro Leu 
        515                 520                 525             


Pro Val Met Thr Gly Gly Phe Leu Ser Cys Ile Leu Gly Leu Val Leu 
    530                 535                 540                 


Pro Leu Ala Tyr Gly Phe Gln Pro Asp Leu Val Leu Val Ala Leu Gly 
545                 550                 555                 560 


Pro Gly His Gly Leu Gln Gly Pro His Ala Ala Leu Leu Ala Ala Met 
                565                 570                 575     


Leu Arg Gly Leu Ala Gly Gly Arg Val Leu Ala Leu Leu Glu Glu Asn 
            580                 585                 590         


Ser Thr Pro Gln Leu Ala Gly Ile Leu Ala Arg Val Leu Asn Gly Glu 
        595                 600                 605             


Ala Pro Pro Ser Leu Gly Pro Ser Ser Val Ala Ser Pro Glu Asp Val 
    610                 615                 620                 


Gln Ala Leu Met Tyr Leu Arg Gly Gln Leu Glu Pro Gln Trp Lys Met 
625                 630                 635                 640 


Leu Gln Cys His Pro His Leu Val Ala 
                645                 


<210> 5819
<211> 264
<212> PRT
<213> Homo sapiens

<400> 5819
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Thr Ser Gly Ser Ala Leu Thr Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu 
    50                  55                  60                  


Gln Leu Leu Asn Leu Phe Ala Tyr Gly Thr Tyr Pro Asp Tyr Ile Ala 
65                  70                  75                  80  


Asn Lys Glu Ser Leu Pro Glu Leu Ser Thr Ala Gln Gln Asn Lys Leu 
                85                  90                  95      


Lys His Leu Thr Ile Val Ser Leu Ala Ser Arg Met Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg Asn Leu Arg Glu Leu 
        115                 120                 125             


Glu Asp Leu Ile Ile Glu Ala Val Tyr Thr Asp Ile Ile Gln Gly Lys 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp Phe Cys Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val Lys Thr Leu His Glu 
                165                 170                 175     


Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly Ile Glu Gln Gln Val 
            180                 185                 190         


Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn Arg Thr Gln Gln Gln 
        195                 200                 205             


Val Glu Ala Glu Val Thr Asn Ile Lys Lys Thr Leu Lys Ala Thr Ala 
    210                 215                 220                 


Ser Ser Ser Ala Gln Glu Met Glu Gln Gln Leu Ala Glu Arg Glu Cys 
225                 230                 235                 240 


Pro Pro His Ala Glu Gln Arg Gln Pro Thr Lys Lys Met Ser Lys Val 
                245                 250                 255     


Lys Gly Leu Val Ser Ser Arg His 
            260                 


<210> 5820
<211> 241
<212> PRT
<213> Homo sapiens

<400> 5820
Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 
1               5                   10                  15      


Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
            20                  25                  30          


Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
        35                  40                  45              


Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 
    50                  55                  60                  


Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 
65                  70                  75                  80  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
                85                  90                  95      


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
            100                 105                 110         


Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 
        115                 120                 125             


Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 
    130                 135                 140                 


Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 
145                 150                 155                 160 


Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 
                165                 170                 175     


Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 
            180                 185                 190         


Leu Glu Asp Thr Cys Lys Thr Ile Glu Ile Gly Phe Glu Ala Pro Pro 
        195                 200                 205             


Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly Ala Asp Ser 
    210                 215                 220                 


Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn Ser Leu Asn 
225                 230                 235                 240 


Glu 
    


<210> 5821
<211> 1166
<212> PRT
<213> Homo sapiens

<400> 5821
Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Ile Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp 
        115                 120                 125             


Trp Ile Ala Tyr Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ile His His Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Tyr Arg Ser Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys 
            260                 265                 270         


Asn Tyr Met Gln Arg Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln 
                325                 330                 335     


Glu Gly Glu Pro Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu 
            340                 345                 350         


Arg Arg Asp Phe Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu 
        355                 360                 365             


Ala Leu Arg Arg Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln 
    370                 375                 380                 


Glu Glu Tyr Lys Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu 
385                 390                 395                 400 


Gln Gln Lys Glu Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu 
                405                 410                 415     


Arg Glu Ala Arg Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln 
            420                 425                 430         


Glu Glu Lys Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu 
        435                 440                 445             


Glu Glu Arg Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu 
    450                 455                 460                 


Gln Glu Tyr Ile Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu 
465                 470                 475                 480 


Val Leu Gln Gln Gln Leu Leu Gln Glu Gln Ala Met Leu Leu His Asp 
                485                 490                 495     


His Arg Arg Pro His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln 
            500                 505                 510         


Gln Glu Arg Ser Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His 
        515                 520                 525             


Tyr Glu Pro Ala Asp Arg Ala Arg Glu Val Pro Val Arg Thr Thr Ser 
    530                 535                 540                 


Arg Ser Pro Val Leu Ser Arg Arg Asp Ser Pro Leu Gln Gly Ser Gly 
545                 550                 555                 560 


Gln Gln Asn Ser Gln Ala Gly Gln Arg Asn Ser Thr Ser Ser Ile Glu 
                565                 570                 575     


Pro Arg Leu Leu Trp Glu Arg Val Glu Lys Leu Val Pro Arg Pro Gly 
            580                 585                 590         


Ser Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly Ser Gln Pro Gly Ser 
        595                 600                 605             


His Pro Gly Ser Gln Ser Gly Ser Gly Glu Arg Phe Arg Val Arg Ser 
    610                 615                 620                 


Ser Ser Lys Ser Glu Gly Ser Pro Ser Gln Arg Leu Glu Asn Ala Val 
625                 630                 635                 640 


Lys Lys Pro Glu Asp Lys Lys Glu Val Phe Arg Pro Leu Lys Pro Ala 
                645                 650                 655     


Val Arg Ile Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val Glu 
            660                 665                 670         


Asp Val Arg Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu 
        675                 680                 685             


Glu Ser Gly Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gln Glu Gly 
    690                 695                 700                 


Ala Asp Glu Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser Ser 
705                 710                 715                 720 


Leu Asn Leu Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met Ile Val 
                725                 730                 735     


His Asp Asp Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu Gly 
            740                 745                 750         


Thr Leu Ile Val Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu Gln Lys 
        755                 760                 765             


His Lys Ser Ser Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg Leu Leu 
    770                 775                 780                 


Gln Ile Ser Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly Phe 
785                 790                 795                 800 


Ser Cys Asp Gly Met Arg Pro Glu Ala Ile Arg Gln Asp Pro Thr Arg 
                805                 810                 815     


Lys Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gln Ser 
            820                 825                 830         


Asp Thr Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu Ile 
        835                 840                 845             


Leu Cys Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu Ser 
    850                 855                 860                 


Gly Leu Met Leu Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Pro Leu 
865                 870                 875                 880 


Ile Asn Arg Arg Arg Phe Gln Gln Met Asp Val Leu Glu Gly Leu Asn 
                885                 890                 895     


Val Leu Val Thr Ile Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr Tyr 
            900                 905                 910         


Leu Ser Trp Leu Arg Asn Lys Ile Leu His Asn Asp Pro Glu Val Glu 
        915                 920                 925             


Lys Lys Gln Gly Trp Thr Thr Val Gly Asp Leu Glu Gly Cys Val His 
    930                 935                 940                 


Tyr Lys Val Val Lys Tyr Glu Arg Ile Lys Phe Leu Val Ile Ala Leu 
945                 950                 955                 960 


Lys Ser Ser Val Glu Val Tyr Ala Trp Ala Pro Lys Pro Tyr His Lys 
                965                 970                 975     


Phe Met Ala Phe Lys Ser Phe Gly Glu Leu Val His Lys Pro Leu Leu 
            980                 985                 990         


Val Asp Leu Thr Val Glu Glu Gly  Gln Arg Leu Lys Val  Ile Tyr Gly 
        995                 1000                 1005             


Ser Cys  Ala Gly Phe His Ala  Val Asp Val Asp Ser  Gly Ser Val 
    1010                 1015                 1020             


Tyr Asp  Ile Tyr Leu Pro Thr  His Val Arg Lys Asn  Pro His Ser 
    1025                 1030                 1035             


Met Ile  Gln Cys Ser Ile Lys  Pro His Ala Ile Ile  Ile Leu Pro 
    1040                 1045                 1050             


Asn Thr  Asp Gly Met Glu Leu  Leu Val Cys Tyr Glu  Asp Glu Gly 
    1055                 1060                 1065             


Val Tyr  Val Asn Thr Tyr Gly  Arg Ile Thr Lys Asp  Val Val Leu 
    1070                 1075                 1080             


Gln Trp  Gly Glu Met Pro Thr  Ser Val Ala Tyr Ile  Arg Ser Asn 
    1085                 1090                 1095             


Gln Thr  Met Gly Trp Gly Glu  Lys Ala Ile Glu Ile  Arg Ser Val 
    1100                 1105                 1110             


Glu Thr  Gly His Leu Asp Gly  Val Phe Met His Lys  Arg Ala Gln 
    1115                 1120                 1125             


Arg Leu  Lys Phe Leu Cys Glu  Arg Asn Asp Lys Val  Phe Phe Ala 
    1130                 1135                 1140             


Ser Val  Arg Ser Gly Gly Ser  Ser Gln Val Tyr Phe  Met Thr Leu 
    1145                 1150                 1155             


Gly Arg  Thr Ser Leu Leu Ser  Trp 
    1160                 1165     


<210> 5822
<211> 821
<212> PRT
<213> Homo sapiens

<400> 5822
Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Thr Trp Lys Thr Gly Gln Val Glu Arg Gly Arg 
145                 150                 155                 160 


Ala Trp Lys Pro Pro Ala Ser Leu Ala Leu Cys Ser Arg Ser Cys Asp 
                165                 170                 175     


Ser Met Val Ser Cys Tyr Ala Ser Ile Leu Cys Lys Ala Leu Trp Lys 
            180                 185                 190         


Glu Lys Leu His Thr Phe Trp His His Asn Arg Ile Ser Phe Leu Pro 
        195                 200                 205             


Ser Ala Phe Arg Pro Ile Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys 
    210                 215                 220                 


Arg Ile His Ile Phe Ala Gln Gln Asn Asp Gln Phe Gln Lys Val Leu 
225                 230                 235                 240 


Ser Leu Cys Gly His Glu Asp Trp Ile Arg Gly Val Glu Trp Ala Ala 
                245                 250                 255     


Phe Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile 
            260                 265                 270         


Arg Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp 
        275                 280                 285             


Asp Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu 
    290                 295                 300                 


Ser Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val Leu Ala Gly 
305                 310                 315                 320 


His Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val Phe Tyr Lys 
                325                 330                 335     


Asp Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala Ser Met Asp 
            340                 345                 350         


Lys Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly Val Trp Leu 
        355                 360                 365             


Glu Gln Arg Glu Trp Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp 
    370                 375                 380                 


Gly Val Gln Asp Leu Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr 
385                 390                 395                 400 


Val Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys 
                405                 410                 415     


Asp Gln Ser Gln Val Thr Trp His Glu Ile Ala Arg Pro Gln Ile His 
            420                 425                 430         


Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val 
        435                 440                 445             


Ser Gly Ala Asp Glu Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn 
    450                 455                 460                 


Phe Val Glu Asn Phe Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val 
465                 470                 475                 480 


Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala 
                485                 490                 495     


Leu Gly Leu Ser Asn Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln 
            500                 505                 510         


Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln 
        515                 520                 525             


Gln Val Ala Phe Gln Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp 
    530                 535                 540                 


His Leu Leu Gln Asn Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly 
545                 550                 555                 560 


His Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu 
                565                 570                 575     


Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile 
            580                 585                 590         


Leu Trp Asn Thr Thr Ser Trp Lys Gln Val Gln Asn Leu Val Phe His 
        595                 600                 605             


Ser Leu Thr Val Thr Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu 
    610                 615                 620                 


Leu Ala Val Ser Arg Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp 
625                 630                 635                 640 


Thr Ile Ser Pro Glu Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr 
                645                 650                 655     


Asn Lys Ile Thr Ser Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp 
            660                 665                 670         


Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val 
        675                 680                 685             


Val Val Trp Gly Glu Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn 
    690                 695                 700                 


Ile Gly Pro Cys Ser Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala 
705                 710                 715                 720 


Val Ser Val Cys Pro Val Leu His Pro Ser Gln Arg Tyr Val Val Ala 
                725                 730                 735     


Val Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr 
            740                 745                 750         


Asp Gln Val Pro Glu Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser 
        755                 760                 765             


Gln Ser Gln Ser His Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn 
    770                 775                 780                 


Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu 
785                 790                 795                 800 


His Phe Ala Ser Cys Gly Glu Asp His Thr Val Lys Ile His Arg Val 
                805                 810                 815     


Asn Lys Cys Ala Leu 
            820     


<210> 5823
<211> 322
<212> PRT
<213> Homo sapiens

<400> 5823
Met Val Ser Val Ile Asn Thr Val Asp Thr Ser His Glu Asp Met Ile 
1               5                   10                  15      


His Asp Ala Gln Met Asp Tyr Tyr Gly Thr Arg Leu Ala Thr Cys Ser 
            20                  25                  30          


Ser Asp Arg Ser Val Lys Ile Phe Asp Val Arg Asn Gly Gly Gln Ile 
        35                  40                  45              


Leu Ile Ala Asp Leu Arg Gly His Glu Gly Pro Val Trp Gln Val Ala 
    50                  55                  60                  


Trp Ala His Pro Met Tyr Gly Asn Ile Leu Ala Ser Cys Ser Tyr Asp 
65                  70                  75                  80  


Arg Lys Val Ile Ile Trp Arg Glu Glu Asn Gly Thr Trp Glu Lys Ser 
                85                  90                  95      


His Glu His Ala Gly His Asp Ser Ser Val Asn Ser Val Cys Trp Ala 
            100                 105                 110         


Pro His Asp Tyr Gly Leu Ile Leu Ala Cys Gly Ser Ser Asp Gly Ala 
        115                 120                 125             


Ile Ser Leu Leu Thr Tyr Thr Gly Glu Gly Gln Trp Glu Val Lys Lys 
    130                 135                 140                 


Ile Asn Asn Ala His Thr Ile Gly Cys Asn Ala Val Ser Trp Ala Pro 
145                 150                 155                 160 


Ala Val Val Pro Gly Ser Leu Ile Asp His Pro Ser Gly Gln Lys Pro 
                165                 170                 175     


Asn Tyr Ile Lys Arg Phe Ala Ser Gly Gly Cys Asp Asn Leu Ile Lys 
            180                 185                 190         


Leu Trp Lys Glu Glu Glu Asp Gly Gln Trp Lys Glu Glu Gln Lys Leu 
        195                 200                 205             


Glu Ala His Ser Asp Trp Val Arg Asp Val Ala Trp Ala Pro Ser Ile 
    210                 215                 220                 


Gly Leu Pro Thr Ser Thr Ile Ala Ser Cys Ser Gln Asp Gly Arg Val 
225                 230                 235                 240 


Phe Ile Trp Thr Cys Asp Asp Ala Ser Ser Asn Thr Trp Ser Pro Lys 
                245                 250                 255     


Leu Leu His Lys Phe Asn Asp Val Val Trp His Val Ser Trp Ser Ile 
            260                 265                 270         


Thr Ala Asn Ile Leu Ala Val Ser Gly Gly Asp Asn Lys Val Thr Leu 
        275                 280                 285             


Trp Lys Glu Ser Val Asp Gly Gln Trp Val Cys Ile Ser Asp Val Asn 
    290                 295                 300                 


Lys Gly Gln Gly Ser Val Ser Ala Ser Val Thr Glu Gly Gln Gln Asn 
305                 310                 315                 320 


Glu Gln 
        


<210> 5824
<211> 448
<212> PRT
<213> Homo sapiens

<400> 5824
Met Ser Ser Arg Lys Leu Ser Gly Pro Lys Gly Arg Arg Leu Ser Ile 
1               5                   10                  15      


His Val Val Thr Trp Asn Val Ala Ser Ala Ala Pro Pro Leu Asp Leu 
            20                  25                  30          


Ser Asp Leu Leu Gln Leu Asn Asn Arg Asn Leu Asn Leu Asp Ile Tyr 
        35                  40                  45              


Val Ile Gly Leu Gln Glu Leu Asn Ser Gly Ile Ile Ser Leu Leu Ser 
    50                  55                  60                  


Asp Ala Ala Phe Asn Asp Ser Trp Ser Ser Phe Leu Met Asp Val Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Phe Ile Lys Val Ser His Val Arg Met Gln Gly Ile 
                85                  90                  95      


Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro Tyr Ile Gln Ile 
            100                 105                 110         


Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly Tyr Trp Gly Asn 
        115                 120                 125             


Lys Gly Gly Val Asn Ile Cys Leu Lys Leu Tyr Gly Tyr Tyr Val Ser 
    130                 135                 140                 


Ile Ile Asn Cys His Leu Pro Pro His Ile Ser Asn Asn Tyr Gln Arg 
145                 150                 155                 160 


Leu Glu His Phe Asp Arg Ile Leu Glu Met Gln Asn Cys Glu Gly Arg 
                165                 170                 175     


Asp Ile Pro Asn Ile Leu Asp His Asp Leu Ile Ile Trp Phe Gly Asp 
            180                 185                 190         


Met Asn Phe Arg Ile Glu Asp Phe Gly Leu His Phe Val Arg Glu Ser 
        195                 200                 205             


Ile Lys Asn Arg Cys Tyr Gly Gly Leu Trp Glu Lys Asp Gln Leu Ser 
    210                 215                 220                 


Ile Ala Lys Lys His Asp Pro Leu Leu Arg Glu Phe Gln Glu Gly Arg 
225                 230                 235                 240 


Leu Leu Phe Pro Pro Thr Tyr Lys Phe Asp Arg Asn Ser Asn Asp Tyr 
                245                 250                 255     


Asp Thr Ser Glu Lys Lys Arg Lys Pro Ala Trp Thr Asp Arg Ile Leu 
            260                 265                 270         


Trp Arg Leu Lys Arg Gln Pro Cys Ala Gly Pro Asp Thr Pro Ile Pro 
        275                 280                 285             


Pro Ala Ser His Phe Ser Leu Ser Leu Arg Gly Tyr Ser Ser His Met 
    290                 295                 300                 


Thr Tyr Gly Ile Ser Asp His Lys Pro Val Ser Gly Thr Phe Asp Leu 
305                 310                 315                 320 


Glu Leu Lys Pro Leu Val Ser Ala Pro Leu Ile Val Leu Met Pro Glu 
                325                 330                 335     


Asp Leu Trp Thr Val Glu Asn Asp Met Met Val Ser Tyr Ser Ser Thr 
            340                 345                 350         


Ser Asp Phe Pro Ser Ser Pro Trp Asp Trp Ile Gly Leu Tyr Lys Val 
        355                 360                 365             


Gly Leu Arg Asp Val Asn Asp Tyr Val Ser Tyr Ala Trp Val Gly Asp 
    370                 375                 380                 


Ser Lys Val Ser Cys Ser Asp Asn Leu Asn Gln Val Tyr Ile Asp Ile 
385                 390                 395                 400 


Ser Asn Ile Pro Thr Thr Glu Asp Glu Phe Leu Leu Cys Tyr Tyr Ser 
                405                 410                 415     


Asn Ser Leu Arg Ser Val Val Gly Ile Ser Arg Pro Phe Gln Ile Pro 
            420                 425                 430         


Pro Gly Ser Leu Arg Glu Asp Pro Leu Gly Glu Ala Gln Pro Gln Ile 
        435                 440                 445             


<210> 5825
<211> 546
<212> PRT
<213> Homo sapiens

<400> 5825
Met Gly Ala Tyr Leu Ser Gln Pro Asn Thr Val Lys Cys Ser Gly Asp 
1               5                   10                  15      


Gly Val Gly Ala Pro Arg Leu Pro Leu Pro Tyr Gly Phe Ser Ala Met 
            20                  25                  30          


Gln Gly Trp Arg Val Ser Met Glu Asp Ala His Asn Cys Ile Pro Glu 
        35                  40                  45              


Leu Asp Ser Glu Thr Ala Met Phe Ser Val Tyr Asp Gly His Gly Gly 
    50                  55                  60                  


Glu Glu Val Ala Leu Tyr Cys Ala Lys Tyr Leu Pro Asp Ile Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Ala Tyr Lys Glu Gly Lys Leu Gln Lys Ala Leu Glu Asp 
                85                  90                  95      


Ala Phe Leu Ala Ile Asp Ala Lys Leu Thr Thr Glu Glu Val Ile Lys 
            100                 105                 110         


Glu Leu Ala Gln Ile Ala Gly Arg Pro Thr Glu Asp Glu Asp Glu Lys 
        115                 120                 125             


Glu Lys Val Ala Asp Glu Asp Asp Val Asp Asn Glu Glu Ala Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ala Thr Met Thr Ile Glu Glu Leu Leu Thr Arg Tyr 
145                 150                 155                 160 


Gly Gln Asn Cys His Lys Gly Pro Pro His Ser Lys Ser Gly Gly Gly 
                165                 170                 175     


Thr Gly Glu Glu Pro Gly Ser Gln Gly Leu Asn Gly Glu Ala Gly Pro 
            180                 185                 190         


Glu Asp Ser Thr Arg Glu Thr Pro Ser Gln Glu Asn Gly Pro Thr Ala 
        195                 200                 205             


Lys Ala Tyr Thr Gly Phe Ser Ser Asn Ser Glu Arg Gly Thr Glu Ala 
    210                 215                 220                 


Gly Gln Val Gly Glu Pro Gly Ile Pro Thr Gly Glu Ala Gly Pro Ser 
225                 230                 235                 240 


Cys Ser Ser Ala Ser Asp Lys Leu Pro Arg Val Ala Lys Ser Lys Phe 
                245                 250                 255     


Phe Glu Asp Ser Glu Asp Glu Ser Asp Glu Ala Glu Glu Glu Glu Glu 
            260                 265                 270         


Asp Ser Glu Glu Cys Ser Glu Glu Glu Asp Gly Tyr Ser Ser Glu Glu 
        275                 280                 285             


Ala Glu Asn Glu Glu Asp Glu Asp Asp Thr Glu Glu Ala Glu Glu Asp 
    290                 295                 300                 


Asp Glu Glu Glu Glu Glu Glu Met Met Val Pro Gly Met Glu Gly Lys 
305                 310                 315                 320 


Glu Glu Pro Gly Ser Asp Ser Gly Thr Thr Ala Val Val Ala Leu Ile 
                325                 330                 335     


Arg Gly Lys Gln Leu Ile Val Ala Asn Ala Gly Asp Ser Arg Cys Val 
            340                 345                 350         


Val Ser Glu Ala Gly Lys Ala Leu Asp Met Ser Tyr Asp His Lys Pro 
        355                 360                 365             


Glu Asp Glu Val Glu Leu Ala Arg Ile Lys Asn Ala Gly Gly Lys Val 
    370                 375                 380                 


Thr Met Asp Gly Arg Val Asn Gly Gly Leu Asn Leu Ser Arg Ala Ile 
385                 390                 395                 400 


Gly Asp His Phe Tyr Lys Arg Asn Lys Asn Leu Pro Pro Glu Glu Gln 
                405                 410                 415     


Met Ile Ser Ala Leu Pro Asp Ile Lys Val Leu Thr Leu Thr Asp Asp 
            420                 425                 430         


His Glu Phe Met Val Ile Ala Cys Asp Gly Ile Trp Asn Val Met Ser 
        435                 440                 445             


Ser Gln Glu Val Val Asp Phe Ile Gln Ser Lys Ile Ser Gln Arg Asp 
    450                 455                 460                 


Glu Asn Gly Glu Leu Arg Leu Leu Ser Ser Ile Val Glu Glu Leu Leu 
465                 470                 475                 480 


Asp Gln Cys Leu Ala Pro Asp Thr Ser Gly Asp Gly Thr Gly Cys Asp 
                485                 490                 495     


Asn Met Thr Cys Ile Ile Ile Cys Phe Lys Pro Arg Asn Thr Ala Glu 
            500                 505                 510         


Leu Gln Pro Glu Ser Gly Lys Arg Lys Leu Glu Glu Val Leu Ser Thr 
        515                 520                 525             


Glu Gly Ala Glu Glu Asn Gly Asn Ser Asp Lys Lys Lys Lys Ala Lys 
    530                 535                 540                 


Arg Asp 
545     


<210> 5826
<211> 1279
<212> PRT
<213> Homo sapiens

<400> 5826
Met Leu Gln Ala Leu Gln Leu Arg Thr Gly Phe Phe Cys Phe Arg Val 
1               5                   10                  15      


Leu Val Ala Leu Ser Pro Cys Ala Leu His Asp Ser Gly Arg Leu Thr 
            20                  25                  30          


Thr Gly Ser Phe Asn Val Val Arg Asp Glu Glu Glu Glu Ile Lys Leu 
        35                  40                  45              


Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg Asn Ile Ala Thr 
    50                  55                  60                  


Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly His Asp Asp Gln 
65                  70                  75                  80  


Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser Ile Thr Asp Leu 
                85                  90                  95      


Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp Trp Ile Ala Tyr 
            100                 105                 110         


Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu His Ile His His 
        115                 120                 125             


Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu Leu Thr Glu Asn 
    130                 135                 140                 


Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala Gln Leu Asp Arg 
145                 150                 155                 160 


Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro Tyr Trp Met Ala 
                165                 170                 175     


Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala Thr Tyr Asp Tyr 
            180                 185                 190         


Arg Ser Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile Glu Met Ala Glu 
        195                 200                 205             


Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg Ala Leu Phe Leu 
    210                 215                 220                 


Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys Lys Trp Ser Lys 
225                 230                 235                 240 


Lys Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys Asn Tyr Met Gln 
                245                 250                 255     


Arg Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe Ile Arg Asp Gln 
            260                 265                 270         


Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp His Ile Asp Arg 
        275                 280                 285             


Thr Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu Tyr Glu Tyr Ser 
    290                 295                 300                 


Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln Glu Gly Glu Pro 
305                 310                 315                 320 


Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu Arg Arg Asp Phe 
                325                 330                 335     


Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu Ala Leu Arg Arg 
            340                 345                 350         


Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln Glu Glu Tyr Lys 
        355                 360                 365             


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Gln Gln Lys Glu 
    370                 375                 380                 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Arg Glu Ala Arg 
385                 390                 395                 400 


Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln Glu Glu Lys Arg 
                405                 410                 415     


Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg 
            420                 425                 430         


Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu Gln Glu Tyr Ile 
        435                 440                 445             


Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu Val Leu Gln Gln 
    450                 455                 460                 


Gln Leu Leu Gln Glu Gln Ala Met Leu Leu His Asp His Arg Arg Pro 
465                 470                 475                 480 


His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln Gln Glu Arg Ser 
                485                 490                 495     


Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr Glu Pro Ala 
            500                 505                 510         


Asp Arg Ala Arg Glu Val Gln Trp Ser His Leu Ala Ser Leu Lys Asn 
        515                 520                 525             


Asn Val Ser Pro Val Ser Arg Ser His Ser Phe Ser Asp Pro Ser Pro 
    530                 535                 540                 


Lys Phe Ala His His His Leu Arg Ser Gln Asp Pro Cys Pro Pro Ser 
545                 550                 555                 560 


Arg Ser Glu Val Leu Ser Gln Ser Ser Asp Ser Lys Ser Glu Ala Pro 
                565                 570                 575     


Asp Pro Thr Gln Lys Ala Trp Ser Arg Ser Asp Ser Asp Glu Val Pro 
            580                 585                 590         


Pro Arg Val Pro Val Arg Thr Thr Ser Arg Ser Pro Val Leu Ser Arg 
        595                 600                 605             


Arg Asp Ser Pro Leu Gln Gly Ser Gly Gln Gln Asn Ser Gln Ala Gly 
    610                 615                 620                 


Gln Arg Asn Ser Thr Ser Ser Ile Glu Pro Arg Leu Leu Trp Glu Arg 
625                 630                 635                 640 


Val Glu Lys Leu Val Pro Arg Pro Gly Ser Gly Ser Ser Ser Gly Ser 
                645                 650                 655     


Ser Asn Ser Gly Ser Gln Pro Gly Ser His Pro Gly Ser Gln Ser Gly 
            660                 665                 670         


Ser Gly Glu Arg Phe Arg Val Arg Ser Ser Ser Lys Ser Glu Gly Ser 
        675                 680                 685             


Pro Ser Gln Arg Leu Glu Asn Ala Val Lys Lys Pro Glu Asp Lys Lys 
    690                 695                 700                 


Glu Val Phe Arg Pro Leu Lys Pro Ala Val Arg Ile Asp Leu Thr Ala 
705                 710                 715                 720 


Leu Ala Lys Glu Leu Arg Ala Val Glu Asp Val Arg Pro Pro His Lys 
                725                 730                 735     


Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser Gly Thr Thr Asp Glu 
            740                 745                 750         


Glu Asp Asp Asp Val Glu Gln Glu Gly Ala Asp Glu Ser Thr Ser Gly 
        755                 760                 765             


Pro Glu Asp Thr Arg Ala Ala Ser Ser Leu Asn Leu Ser Asn Gly Glu 
    770                 775                 780                 


Thr Glu Ser Val Lys Thr Met Ile Val His Asp Asp Val Glu Ser Glu 
785                 790                 795                 800 


Pro Ala Met Thr Pro Ser Lys Glu Gly Thr Leu Ile Val Arg Gln Ser 
                805                 810                 815     


Thr Val Asp Gln Lys Arg Ala Ser His His Glu Ser Asn Gly Phe Ala 
            820                 825                 830         


Gly Arg Ile His Leu Leu Pro Asp Leu Leu Gln Gln Ser His Ser Ser 
        835                 840                 845             


Ser Thr Ser Ser Thr Ser Ser Ser Pro Ser Ser Ser Gln Pro Thr Pro 
    850                 855                 860                 


Thr Met Ser Pro Gln Thr Pro Gln Asp Lys Leu Thr Ala Asn Glu Thr 
865                 870                 875                 880 


Gln Ser Ala Ser Ser Thr Leu Gln Lys His Lys Ser Ser Ser Ser Phe 
                885                 890                 895     


Thr Pro Phe Ile Asp Pro Arg Leu Leu Gln Ile Ser Pro Ser Ser Gly 
            900                 905                 910         


Thr Thr Val Thr Ser Val Val Gly Phe Ser Cys Asp Gly Met Arg Pro 
        915                 920                 925             


Glu Ala Ile Arg Gln Asp Pro Thr Arg Lys Gly Ser Val Val Asn Val 
    930                 935                 940                 


Asn Pro Thr Asn Thr Arg Pro Gln Ser Asp Thr Pro Glu Ile Arg Lys 
945                 950                 955                 960 


Tyr Lys Lys Arg Phe Asn Ser Glu Ile Leu Cys Ala Ala Leu Trp Gly 
                965                 970                 975     


Val Asn Leu Leu Val Gly Thr Glu Ser Gly Leu Met Leu Leu Asp Arg 
            980                 985                 990         


Ser Gly Gln Gly Lys Val Tyr Pro  Leu Ile Asn Arg Arg  Arg Phe Gln 
        995                 1000                 1005             


Gln Met  Asp Val Leu Glu Gly  Leu Asn Val Leu Val  Thr Ile Ser 
    1010                 1015                 1020             


Gly Lys  Lys Asp Lys Leu Arg  Val Tyr Tyr Leu Ser  Trp Leu Arg 
    1025                 1030                 1035             


Asn Lys  Ile Leu His Asn Asp  Pro Glu Val Glu Lys  Lys Gln Gly 
    1040                 1045                 1050             


Trp Thr  Thr Val Gly Asp Leu  Glu Gly Cys Val His  Tyr Lys Val 
    1055                 1060                 1065             


Val Lys  Tyr Glu Arg Ile Lys  Phe Leu Val Ile Ala  Leu Lys Ser 
    1070                 1075                 1080             


Ser Val  Glu Val Tyr Ala Trp  Ala Pro Lys Pro Tyr  His Lys Phe 
    1085                 1090                 1095             


Met Ala  Phe Lys Ser Phe Gly  Glu Leu Val His Lys  Pro Leu Leu 
    1100                 1105                 1110             


Val Asp  Leu Thr Val Glu Glu  Gly Gln Arg Leu Lys  Val Ile Tyr 
    1115                 1120                 1125             


Gly Ser  Cys Ala Gly Phe His  Ala Val Asp Val Asp  Ser Gly Ser 
    1130                 1135                 1140             


Val Tyr  Asp Ile Tyr Leu Pro  Thr His Ile Gln Cys  Ser Ile Lys 
    1145                 1150                 1155             


Pro His  Ala Ile Ile Ile Leu  Pro Asn Thr Asp Gly  Met Glu Leu 
    1160                 1165                 1170             


Leu Val  Cys Tyr Glu Asp Glu  Gly Val Tyr Val Asn  Thr Tyr Gly 
    1175                 1180                 1185             


Arg Ile  Thr Lys Asp Val Val  Leu Gln Trp Gly Glu  Met Pro Thr 
    1190                 1195                 1200             


Ser Val  Ala Tyr Ile Arg Ser  Asn Gln Thr Met Gly  Trp Gly Glu 
    1205                 1210                 1215             


Lys Ala  Ile Glu Ile Arg Ser  Val Glu Thr Gly His  Leu Asp Gly 
    1220                 1225                 1230             


Val Phe  Met His Lys Arg Ala  Gln Arg Leu Lys Phe  Leu Cys Glu 
    1235                 1240                 1245             


Arg Asn  Asp Lys Val Phe Phe  Ala Ser Val Arg Ser  Gly Gly Ser 
    1250                 1255                 1260             


Ser Gln  Val Tyr Phe Met Thr  Leu Gly Arg Thr Ser  Leu Leu Ser 
    1265                 1270                 1275             


Trp 
    


<210> 5827
<211> 662
<212> PRT
<213> Homo sapiens

<400> 5827
Met Ala Ser Cys Pro Asp Ser Asp Asn Ser Trp Val Leu Ala Gly Ser 
1               5                   10                  15      


Glu Ser Leu Pro Val Glu Thr Leu Gly Pro Ala Ser Arg Met Asp Pro 
            20                  25                  30          


Glu Ser Glu Arg Ala Leu Gln Ala Pro His Ser Pro Ser Lys Thr Asp 
        35                  40                  45              


Gly Lys Glu Leu Ala Gly Thr Met Asp Gly Glu Gly Thr Leu Phe Gln 
    50                  55                  60                  


Thr Glu Ser Pro Gln Ser Gly Ser Ile Leu Thr Glu Glu Thr Glu Val 
65                  70                  75                  80  


Lys Gly Thr Leu Glu Gly Asp Val Cys Gly Val Glu Pro Pro Gly Pro 
                85                  90                  95      


Gly Asp Thr Val Val Gln Gly Asp Leu Gln Glu Thr Thr Val Val Thr 
            100                 105                 110         


Gly Leu Gly Pro Asp Thr Gln Asp Leu Glu Gly Gln Ser Pro Pro Gln 
        115                 120                 125             


Ser Leu Pro Ser Thr Pro Lys Ala Ala Trp Ile Arg Glu Glu Gly Arg 
    130                 135                 140                 


Cys Ser Ser Ser Asp Asp Asp Thr Asp Val Asp Met Glu Gly Leu Arg 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Glu Ala Gly Pro Pro Gln Pro Met Val Pro Leu 
                165                 170                 175     


Ala Val Glu Asn Gln Ala Gly Gly Glu Gly Ala Gly Gly Glu Leu Gly 
            180                 185                 190         


Ile Ser Leu Asn Met Cys Leu Leu Gly Ala Leu Val Leu Leu Gly Leu 
        195                 200                 205             


Gly Val Leu Leu Phe Ser Gly Gly Leu Ser Glu Ser Glu Thr Gly Pro 
    210                 215                 220                 


Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu Val Leu Glu 
225                 230                 235                 240 


Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu Gln Ala Pro 
                245                 250                 255     


Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly Leu Leu Leu 
            260                 265                 270         


Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu Gln Ala Gln 
        275                 280                 285             


Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu Met His Gln Pro Lys 
    290                 295                 300                 


Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly Ala Leu Gln Gln Gly 
305                 310                 315                 320 


Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu Gln Gln Leu Arg Ala 
                325                 330                 335     


Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg Gly Pro Asp Gly Val 
            340                 345                 350         


Cys Leu Ser Gly Gly Arg Gly Pro Gln Gly Asp Lys Ala Ile Arg Glu 
        355                 360                 365             


Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser Phe Leu Lys Gln Lys 
    370                 375                 380                 


Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg Gln Glu Leu Glu Arg 
385                 390                 395                 400 


Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp Leu Glu Arg Ser Leu 
                405                 410                 415     


Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala Gly Leu Ala Glu Leu 
            420                 425                 430         


Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu Glu Asn Trp Gly Gln 
        435                 440                 445             


Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala Trp His Gln Lys Ser 
    450                 455                 460                 


His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys Glu Lys Trp Trp Asp 
465                 470                 475                 480 


Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys His Lys Lys Glu Glu 
                485                 490                 495     


Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly Gln Glu Asp Arg Glu 
            500                 505                 510         


Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg Val Glu Glu Ser Gly 
        515                 520                 525             


Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys Glu Pro Pro Arg Lys 
    530                 535                 540                 


Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln Lys Gln Pro Arg Trp 
545                 550                 555                 560 


Arg Glu Gly Thr Lys Glu Leu Pro Leu Ser Pro Ala Phe Phe Gly Glu 
                565                 570                 575     


Asp Gly Ile Phe Arg His Asp Arg Leu Arg Phe Arg Asp Phe Val Asp 
            580                 585                 590         


Ala Leu Glu Asp Ser Leu Glu Glu Val Ala Val Gln Gln Thr Gly Asp 
        595                 600                 605             


Asp Asp Glu Val Asp Asp Phe Glu Asp Phe Ile Phe Ser His Phe Phe 
    610                 615                 620                 


Gly Asp Lys Ala Leu Lys Lys Arg Ser Gly Lys Lys Asp Lys His Ser 
625                 630                 635                 640 


Gln Ser Pro Arg Ala Ala Gly Pro Arg Glu Gly His Ser His Ser His 
                645                 650                 655     


His His His His Arg Gly 
            660         


<210> 5828
<211> 800
<212> PRT
<213> Homo sapiens

<400> 5828
Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg 
145                 150                 155                 160 


Ile His Ile Phe Ala Gln Gln Asn Asp Gln Phe Gln Lys Val Leu Ser 
                165                 170                 175     


Leu Cys Gly His Glu Asp Trp Ile Arg Gly Val Glu Trp Ala Ala Phe 
            180                 185                 190         


Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg 
        195                 200                 205             


Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp 
    210                 215                 220                 


Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser 
225                 230                 235                 240 


Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val Leu Ala Gly His 
                245                 250                 255     


Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val Phe Tyr Lys Asp 
            260                 265                 270         


Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala Ser Met Asp Lys 
        275                 280                 285             


Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly Val Trp Leu Glu 
    290                 295                 300                 


Gln Val Arg Val Gly Glu Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp 
305                 310                 315                 320 


Cys Gln Phe Asn Glu Asp Gly Ser Met Ile Ile Ala His Ala Phe His 
                325                 330                 335     


Gly Ala Leu His Leu Trp Lys Gln Asn Thr Val Asn Pro Arg Glu Trp 
            340                 345                 350         


Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp Gly Val Gln Asp Leu 
        355                 360                 365             


Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr Val Gly Thr Asp Gln 
    370                 375                 380                 


Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys Asp Gln Ser Gln Val 
385                 390                 395                 400 


Thr Trp His Glu Ile Ala Arg Pro Gln Ile His Gly Tyr Asp Leu Lys 
                405                 410                 415     


Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val Ser Gly Ala Asp Glu 
            420                 425                 430         


Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn Phe Val Glu Asn Phe 
        435                 440                 445             


Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val Leu Cys Asn Gln Asp 
    450                 455                 460                 


Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala Leu Gly Leu Ser Asn 
465                 470                 475                 480 


Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu 
                485                 490                 495     


Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln 
            500                 505                 510         


Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp His Leu Leu Gln Asn 
        515                 520                 525             


Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile 
    530                 535                 540                 


Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys 
545                 550                 555                 560 


Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile Leu Trp Asn Thr Thr 
                565                 570                 575     


Ser Trp Lys Gln Val Gln Asn Leu Val Phe His Ser Leu Thr Val Thr 
            580                 585                 590         


Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu Leu Ala Val Ser Arg 
        595                 600                 605             


Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu 
    610                 615                 620                 


Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser 
625                 630                 635                 640 


Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys 
                645                 650                 655     


Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val Val Val Trp Gly Glu 
            660                 665                 670         


Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn Ile Gly Pro Cys Ser 
        675                 680                 685             


Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala Val Ser Val Cys Pro 
    690                 695                 700                 


Val Leu His Pro Ser Gln Arg Tyr Val Val Ala Val Gly Leu Glu Cys 
705                 710                 715                 720 


Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr Asp Gln Val Pro Glu 
                725                 730                 735     


Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser Gln Ser Gln Ser His 
            740                 745                 750         


Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr 
        755                 760                 765             


Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu His Phe Ala Ser Cys 
    770                 775                 780                 


Gly Glu Asp His Thr Val Lys Ile His Arg Val Asn Lys Cys Ala Leu 
785                 790                 795                 800 


<210> 5829
<211> 186
<212> PRT
<213> Homo sapiens

<400> 5829
Met Ala Gly Glu Asn Phe Ala Thr Pro Phe His Gly His Val Gly Arg 
1               5                   10                  15      


Gly Ala Phe Ser Asp Val Tyr Glu Pro Ala Glu Asp Thr Phe Leu Leu 
            20                  25                  30          


Leu Asn Ala Leu Glu Ala Ala Ala Ala Glu Leu Ala Gly Val Glu Ile 
        35                  40                  45              


Cys Leu Glu Val Gly Ser Gly Ser Gly Val Val Ser Ala Phe Leu Ala 
    50                  55                  60                  


Ser Met Ile Gly Pro Gln Ala Leu Tyr Met Cys Thr Asp Ile Asn Pro 
65                  70                  75                  80  


Glu Ala Ala Ala Cys Thr Leu Glu Thr Ala Arg Cys Asn Lys Val His 
                85                  90                  95      


Ile Gln Pro Val Ile Thr Asp Leu Val Gly Ser His Gly Ile Glu Ala 
            100                 105                 110         


Ala Trp Ala Gly Gly Lys Asn Gly Arg Glu Val Met Asp Arg Phe Phe 
        115                 120                 125             


Pro Leu Val Pro Asp Leu Leu Ser Pro Lys Gly Leu Phe Tyr Leu Val 
    130                 135                 140                 


Thr Ile Lys Glu Asn Asn Pro Glu Glu Ile Leu Lys Ile Met Lys Thr 
145                 150                 155                 160 


Lys Gly Leu Gln Gly Thr Thr Ala Leu Ser Arg Gln Ala Gly Gln Glu 
                165                 170                 175     


Thr Leu Ser Val Leu Lys Phe Thr Lys Ser 
            180                 185     


<210> 5830
<211> 783
<212> PRT
<213> Homo sapiens

<400> 5830
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala 
        435                 440                 445             


Gly Asn Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Phe Pro Ala Pro 
625                 630                 635                 640 


Pro Lys Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr 
                645                 650                 655     


Ser Asp Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val 
            660                 665                 670         


Gly Lys Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln 
        675                 680                 685             


Glu Lys Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly Glu 
    690                 695                 700                 


Ile Arg Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile Thr Ser Lys 
705                 710                 715                 720 


Lys Trp Gly Thr Arg Asp Leu Gln Val Lys Pro Gly Glu Ser Leu Glu 
                725                 730                 735     


Val Ile Gln Thr Thr Asp Asp Thr Lys Val Leu Cys Arg Asn Glu Glu 
            740                 745                 750         


Gly Lys Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly 
        755                 760                 765             


Glu Ile Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp 
    770                 775                 780             


<210> 5831
<211> 573
<212> PRT
<213> Homo sapiens

<400> 5831
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ile Ser Gly 
                85                  90                  95      


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            100                 105                 110         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        115                 120                 125             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    130                 135                 140                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                165                 170                 175     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Arg Asp 
            180                 185                 190         


Asp Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Val Ser Ala 
        195                 200                 205             


Phe Val Lys Leu Ala Gln Ser Glu Tyr Gln Leu Leu Ala Asp Ile Ile 
    210                 215                 220                 


Pro Glu His His Gln Lys Lys Thr Phe Asp Ser Leu Ile Gln Asp Ala 
225                 230                 235                 240 


Leu Asp Gly Leu Met Leu Glu Gly Glu Asn Ile Val Ser Ala Ala Arg 
                245                 250                 255     


Lys Ala Ile Val Arg His Asp Phe Ser Thr Val Leu Thr Val Phe Pro 
            260                 265                 270         


Ile Leu Arg His Leu Lys Gln Thr Lys Pro Glu Phe Asp Gln Val Leu 
        275                 280                 285             


Gln Gly Thr Ala Ala Ser Thr Lys Asn Lys Leu Pro Gly Leu Ile Thr 
    290                 295                 300                 


Ser Met Glu Thr Ile Gly Ala Lys Ala Leu Glu Asp Phe Ala Asp Asn 
305                 310                 315                 320 


Ile Lys Asn Asp Pro Asp Lys Glu Tyr Asn Met Pro Lys Asp Gly Thr 
                325                 330                 335     


Val His Glu Leu Thr Ser Asn Ala Ile Leu Phe Leu Gln Gln Leu Leu 
            340                 345                 350         


Asp Phe Gln Glu Thr Ala Gly Ala Met Leu Ala Ser Gln Glu Thr Ser 
        355                 360                 365             


Ser Ser Ala Thr Ser Tyr Ser Ser Glu Phe Ser Lys Arg Leu Leu Ser 
    370                 375                 380                 


Thr Tyr Ile Cys Lys Val Leu Gly Asn Leu Gln Leu Asn Leu Leu Ser 
385                 390                 395                 400 


Lys Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser Ala Ile Phe Leu His 
                405                 410                 415     


Asn Asn Tyr Asn Tyr Ile Leu Lys Ser Leu Glu Lys Ser Glu Leu Ile 
            420                 425                 430         


Gln Leu Val Ala Val Thr Gln Lys Thr Ala Glu Arg Ser Tyr Arg Glu 
        435                 440                 445             


His Ile Glu Gln Gln Ile Gln Thr Tyr Gln Arg Ser Trp Leu Lys Val 
    450                 455                 460                 


Thr Asp Tyr Ile Ala Glu Lys Asn Leu Pro Val Phe Gln Pro Gly Val 
465                 470                 475                 480 


Lys Leu Arg Asp Lys Glu Arg Gln Ile Ile Lys Glu Arg Phe Lys Gly 
                485                 490                 495     


Phe Asn Asp Gly Leu Glu Glu Leu Cys Lys Ile Gln Lys Ala Trp Ala 
            500                 505                 510         


Ile Pro Asp Thr Glu Gln Arg Asp Arg Ile Arg Gln Ala Gln Lys Thr 
        515                 520                 525             


Ile Val Lys Glu Thr Tyr Gly Ala Phe Leu Gln Lys Phe Gly Ser Val 
    530                 535                 540                 


Pro Phe Thr Lys Asn Pro Glu Lys Tyr Ile Lys Tyr Gly Val Glu Gln 
545                 550                 555                 560 


Val Gly Asp Met Ile Asp Arg Leu Phe Asp Thr Ser Ala 
                565                 570             


<210> 5832
<211> 824
<212> PRT
<213> Homo sapiens

<400> 5832
Met Met Gln Asn Val His Leu Ala Pro Glu Thr Asp Glu Asp Asp Leu 
1               5                   10                  15      


Tyr Ser Gly Tyr Asn Asp Tyr Asn Pro Ile Tyr Asp Ile Glu Glu Leu 
            20                  25                  30          


Glu Asn Asp Ala Ala Phe Gln Gln Ala Val Arg Thr Ser His Gly Arg 
        35                  40                  45              


Arg Pro Pro Ile Thr Ala Lys Ile Ser Ser Thr Ala Val Thr Arg Pro 
    50                  55                  60                  


Ile Ala Thr Gly Tyr Gly Ser Lys Thr Ser Leu Ala Ser Ser Ile Gly 
65                  70                  75                  80  


Arg Pro Met Thr Gly Ala Ile Gln Asp Gly Val Thr Arg Pro Met Thr 
                85                  90                  95      


Ala Val Arg Ala Ala Gly Phe Thr Lys Ala Ala Leu Arg Gly Ser Ala 
            100                 105                 110         


Phe Asp Pro Leu Ser Gln Ser Arg Gly Pro Ala Ser Pro Leu Glu Ala 
        115                 120                 125             


Lys Lys Lys Asp Ser Pro Glu Glu Lys Ile Lys Gln Leu Glu Lys Glu 
    130                 135                 140                 


Val Asn Glu Leu Val Glu Glu Ser Cys Ile Ala Asn Ser Cys Gly Asp 
145                 150                 155                 160 


Leu Lys Leu Ala Leu Glu Lys Ala Lys Asp Ala Gly Arg Lys Glu Arg 
                165                 170                 175     


Val Leu Val Arg Gln Arg Glu Gln Val Thr Thr Pro Glu Asn Ile Asn 
            180                 185                 190         


Leu Asp Leu Thr Tyr Ser Val Leu Phe Asn Leu Ala Ser Gln Tyr Ser 
        195                 200                 205             


Val Asn Glu Met Tyr Ala Glu Ala Leu Asn Thr Tyr Gln Val Ile Val 
    210                 215                 220                 


Lys Asn Lys Met Phe Ser Asn Ala Gly Ile Leu Lys Met Asn Met Gly 
225                 230                 235                 240 


Asn Ile Tyr Leu Lys Gln Arg Asn Tyr Ser Lys Ala Ile Lys Phe Tyr 
                245                 250                 255     


Arg Met Ala Leu Asp Gln Val Pro Ser Val Asn Lys Gln Met Arg Ile 
            260                 265                 270         


Lys Ile Met Gln Asn Ile Gly Val Thr Phe Ile Gln Ala Gly Gln Tyr 
        275                 280                 285             


Ser Asp Ala Ile Asn Ser Tyr Glu His Ile Met Ser Met Ala Pro Asn 
    290                 295                 300                 


Leu Lys Ala Gly Tyr Asn Leu Thr Ile Cys Tyr Phe Ala Ile Gly Asp 
305                 310                 315                 320 


Arg Glu Lys Met Lys Lys Ala Phe Gln Lys Leu Ile Thr Val Pro Leu 
                325                 330                 335     


Glu Ile Asp Glu Asp Lys Tyr Ile Ser Pro Ser Asp Asp Pro His Thr 
            340                 345                 350         


Asn Leu Val Thr Glu Ala Ile Lys Asn Asp His Leu Arg Gln Met Glu 
        355                 360                 365             


Arg Glu Arg Lys Ala Met Ala Glu Lys Tyr Ile Met Thr Ser Ala Lys 
    370                 375                 380                 


Leu Ile Ala Pro Val Ile Glu Thr Ser Phe Ala Ala Gly Tyr Asp Trp 
385                 390                 395                 400 


Cys Val Glu Val Val Lys Ala Ser Gln Tyr Val Glu Leu Ala Asn Asp 
                405                 410                 415     


Leu Glu Ile Asn Lys Ala Val Thr Tyr Leu Arg Gln Lys Asp Tyr Asn 
            420                 425                 430         


Gln Ala Val Glu Ile Leu Lys Val Leu Glu Lys Lys Asp Ser Arg Val 
        435                 440                 445             


Lys Ser Ala Ala Ala Thr Asn Leu Ser Ala Leu Tyr Tyr Met Gly Lys 
    450                 455                 460                 


Asp Phe Ala Gln Ala Ser Ser Tyr Ala Asp Ile Ala Val Asn Ser Asp 
465                 470                 475                 480 


Arg Tyr Asn Pro Ala Ala Leu Thr Asn Lys Gly Asn Thr Val Phe Ala 
                485                 490                 495     


Asn Gly Asp Tyr Glu Lys Ala Ala Glu Phe Tyr Lys Glu Ala Leu Arg 
            500                 505                 510         


Asn Asp Ser Ser Cys Thr Glu Ala Leu Tyr Asn Ile Gly Leu Thr Tyr 
        515                 520                 525             


Glu Lys Leu Asn Arg Leu Asp Glu Ala Leu Asp Cys Phe Leu Lys Leu 
    530                 535                 540                 


His Ala Ile Leu Arg Asn Ser Ala Glu Val Leu Tyr Gln Ile Ala Asn 
545                 550                 555                 560 


Ile Tyr Glu Leu Met Glu Asn Pro Ser Gln Ala Ile Glu Trp Leu Met 
                565                 570                 575     


Gln Val Val Ser Val Ile Pro Thr Asp Pro Gln Val Leu Ser Lys Leu 
            580                 585                 590         


Gly Glu Leu Tyr Asp Arg Glu Gly Asp Lys Ser Gln Ala Phe Gln Tyr 
        595                 600                 605             


Tyr Tyr Glu Ser Tyr Arg Tyr Phe Pro Cys Asn Ile Glu Val Ile Glu 
    610                 615                 620                 


Trp Leu Gly Ala Tyr Tyr Ile Asp Thr Gln Phe Trp Glu Lys Ala Ile 
625                 630                 635                 640 


Gln Tyr Phe Glu Arg Ala Ser Leu Ile Gln Pro Thr Gln Val Lys Trp 
                645                 650                 655     


Gln Leu Met Val Ala Ser Cys Phe Arg Arg Ser Gly Asn Tyr Gln Lys 
            660                 665                 670         


Ala Leu Asp Thr Tyr Lys Asp Thr His Arg Lys Phe Pro Glu Asn Val 
        675                 680                 685             


Glu Cys Leu Arg Phe Leu Val Arg Leu Cys Thr Asp Leu Gly Leu Lys 
    690                 695                 700                 


Asp Ala Gln Glu Tyr Ala Arg Lys Leu Lys Arg Leu Glu Lys Met Lys 
705                 710                 715                 720 


Glu Ile Arg Glu Gln Arg Ile Lys Ser Gly Arg Asp Gly Ser Gly Gly 
                725                 730                 735     


Ser Arg Gly Lys Arg Glu Gly Ser Ala Ser Gly Asp Ser Gly Gln Asn 
            740                 745                 750         


Tyr Ser Ala Ser Ser Lys Gly Glu Arg Leu Ser Ala Arg Leu Arg Ala 
        755                 760                 765             


Leu Pro Gly Thr Asn Glu Pro Tyr Glu Ser Ser Ser Asn Lys Glu Ile 
    770                 775                 780                 


Asp Ala Ser Tyr Val Asp Pro Leu Gly Pro Gln Ile Glu Arg Pro Lys 
785                 790                 795                 800 


Thr Ala Ala Lys Lys Arg Ile Asp Glu Asp Asp Phe Ala Asp Glu Glu 
                805                 810                 815     


Leu Gly Asp Asp Leu Leu Pro Glu 
            820                 


<210> 5833
<211> 949
<212> PRT
<213> Homo sapiens

<400> 5833
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Gln 
    850                 855                 860                 


Leu Asp Ser Cys Gly Leu Thr Ala Lys Ala Cys Glu Asn Leu Tyr Phe 
865                 870                 875                 880 


Thr Leu Gly Ile Asn Gln Thr Leu Thr Asp Leu Tyr Leu Thr Asn Asn 
                885                 890                 895     


Ala Leu Gly Asp Thr Gly Val Arg Leu Leu Cys Lys Arg Leu Ser His 
            900                 905                 910         


Pro Gly Cys Lys Leu Arg Val Leu Trp Leu Phe Gly Met Asp Leu Asn 
        915                 920                 925             


Lys Met Thr His Ser Arg Leu Ala Ala Leu Arg Val Thr Lys Pro Tyr 
    930                 935                 940                 


Leu Asp Ile Gly Cys 
945                 


<210> 5834
<211> 1931
<212> PRT
<213> Homo sapiens

<400> 5834
Met Ala Ala Arg Ser Ala Pro Ser Cys His Leu Arg Leu Glu Trp Val 
1               5                   10                  15      


Tyr Gly Tyr Arg Gly His Gln Cys Arg Asn Asn Leu Tyr Tyr Thr Ala 
            20                  25                  30          


Ala Lys Glu Ile Val Tyr Phe Val Ala Gly Val Gly Val Val Tyr Ser 
        35                  40                  45              


Pro Arg Glu His Arg Gln Lys Phe Tyr Arg Gly His Ser Asp Asp Ile 
    50                  55                  60                  


Ile Ser Leu Ala Leu His Pro Glu Arg Val Leu Val Ala Thr Gly Gln 
65                  70                  75                  80  


Val Gly Lys Glu Pro Tyr Ile Cys Ile Trp Asp Ser Tyr Thr Val Gln 
                85                  90                  95      


Thr Ile Ser Val Leu Lys Asp Val His Thr His Gly Ile Ala Cys Leu 
            100                 105                 110         


Ala Phe Asp Leu Asp Gly Gln Arg Leu Val Ser Val Gly Leu Asp Ser 
        115                 120                 125             


Lys Asn Ala Val Cys Val Trp Asp Trp Lys Arg Gly Lys Met Leu Ser 
    130                 135                 140                 


Met Ala Pro Gly His Thr Asp Arg Ile Phe Asp Ile Ser Trp Asp Leu 
145                 150                 155                 160 


Tyr Gln Pro Asn Lys Leu Val Ser Cys Gly Val Lys His Ile Lys Phe 
                165                 170                 175     


Trp Ser Leu Cys Gly Asn Ala Leu Thr Pro Lys Arg Gly Val Phe Gly 
            180                 185                 190         


Lys Thr Gly Asp Leu Gln Thr Ile Leu Cys Leu Ala Cys Ala Arg Asp 
        195                 200                 205             


Glu Leu Thr Tyr Ser Gly Ala Leu Asn Gly Asp Ile Tyr Val Trp Lys 
    210                 215                 220                 


Gly Ile Asn Leu Ile Arg Thr Ile Gln Gly Ala His Ala Ala Gly Ile 
225                 230                 235                 240 


Phe Ser Met Asn Ala Cys Glu Glu Gly Phe Ala Thr Gly Gly Arg Asp 
                245                 250                 255     


Gly Cys Ile Arg Leu Trp Asp Leu Thr Phe Lys Pro Ile Thr Val Ile 
            260                 265                 270         


Asp Leu Arg Glu Thr Asp Gln Gly Tyr Lys Gly Leu Ser Val Arg Ser 
        275                 280                 285             


Val Cys Trp Arg Gly Asp His Ile Leu Val Gly Thr Gln Asp Ser Glu 
    290                 295                 300                 


Ile Phe Glu Ile Val Val Gln Glu Arg Asn Lys Pro Phe Leu Ile Met 
305                 310                 315                 320 


Gln Gly His Cys Glu Gly Glu Leu Trp Ala Leu Ala Val His Pro Thr 
                325                 330                 335     


Lys Pro Leu Ala Val Thr Gly Ser Asp Asp Arg Ser Val Arg Ile Trp 
            340                 345                 350         


Ser Leu Val Asp His Ala Leu Ile Ala Arg Cys Asn Met Glu Glu Pro 
        355                 360                 365             


Ile Arg Cys Ala Ala Val Asn Ala Asp Gly Ile His Leu Ala Leu Gly 
    370                 375                 380                 


Met Lys Asp Gly Ser Phe Thr Val Leu Arg Val Arg Asp Met Thr Glu 
385                 390                 395                 400 


Val Val His Ile Lys Asp Arg Lys Glu Ala Ile His Glu Leu Lys Tyr 
                405                 410                 415     


Ser Pro Asp Gly Thr Tyr Leu Ala Val Gly Cys Asn Asp Ser Ser Val 
            420                 425                 430         


Asp Ile Tyr Gly Val Ala Gln Arg Tyr Lys Lys Val Gly Glu Cys Leu 
        435                 440                 445             


Gly Ser Leu Ser Phe Ile Thr His Leu Asp Trp Ser Ser Asp Ser Arg 
    450                 455                 460                 


Tyr Leu Gln Thr Asn Asp Gly Asn Gly Lys Arg Leu Phe Tyr Arg Met 
465                 470                 475                 480 


Pro Gly Gly Lys Glu Val Thr Ser Thr Glu Glu Ile Lys Gly Val His 
                485                 490                 495     


Trp Ala Ser Trp Thr Cys Val Ser Gly Leu Glu Val Asn Gly Ile Trp 
            500                 505                 510         


Pro Lys Tyr Ser Asp Ile Asn Asp Ile Asn Ser Val Asp Gly Asn Tyr 
        515                 520                 525             


Ile Gly Gln Val Leu Val Thr Ala Asp Asp Tyr Gly Ile Ile Lys Leu 
    530                 535                 540                 


Phe Arg Tyr Pro Cys Leu Arg Lys Gly Ala Lys Phe Arg Lys Tyr Ile 
545                 550                 555                 560 


Gly His Ser Ala His Val Thr Asn Val Arg Trp Ser His Asp Tyr Gln 
                565                 570                 575     


Trp Val Ile Ser Ile Gly Gly Ala Asp His Ser Val Phe Gln Trp Lys 
            580                 585                 590         


Phe Ile Pro Glu Arg Lys Leu Lys Asp Ala Val His Ile Ala Pro Gln 
        595                 600                 605             


Glu Ser Leu Ala Asp Ser His Ser Asp Glu Ser Asp Ser Asp Leu Ser 
    610                 615                 620                 


Asp Val Pro Glu Leu Asp Ser Glu Ile Glu Gln Glu Thr Gln Leu Thr 
625                 630                 635                 640 


Tyr Arg Arg Gln Val Tyr Lys Glu Asp Leu Pro Gln Leu Lys Glu Gln 
                645                 650                 655     


Cys Lys Glu Lys Gln Lys Ser Ala Thr Ser Lys Arg Arg Glu Arg Ala 
            660                 665                 670         


Pro Gly Asn Ser Ile Arg Leu His Phe Val His Gly Tyr Arg Gly Tyr 
        675                 680                 685             


Asp Cys Arg Ser Asn Leu Phe Tyr Thr Gln Ile Gly Glu Ile Val Tyr 
    690                 695                 700                 


His Val Ala Ala Val Gly Val Ile Tyr Asn Arg Gln Gln Asn Thr Gln 
705                 710                 715                 720 


Arg Phe Tyr Leu Gly His Asp Asp Asp Ile Leu Cys Leu Thr Ile His 
                725                 730                 735     


Pro Leu Lys Asp Tyr Val Ala Thr Gly Gln Val Gly Arg Asp Pro Ser 
            740                 745                 750         


Ile His Ile Trp Asp Thr Glu Thr Ile Lys Pro Leu Ser Ile Leu Lys 
        755                 760                 765             


Gly His His Gln Tyr Gly Val Ser Ala Val Asp Phe Ser Ala Asp Gly 
    770                 775                 780                 


Lys Arg Leu Ala Ser Val Gly Ile Asp Asp Ser His Thr Val Val Leu 
785                 790                 795                 800 


Trp Asp Trp Lys Lys Gly Glu Lys Leu Ser Ile Ala Arg Gly Ser Lys 
                805                 810                 815     


Asp Lys Ile Phe Val Val Lys Met Asn Pro Tyr Val Pro Asp Lys Leu 
            820                 825                 830         


Ile Thr Ala Gly Ile Lys His Met Lys Phe Trp Arg Lys Ala Gly Asp 
        835                 840                 845             


Val Cys Ile Trp Arg Asp Ile Phe Leu Val Lys Thr Val Lys Ala His 
    850                 855                 860                 


Asp Gly Pro Val Phe Ser Met His Ala Leu Glu Lys Gly Phe Val Thr 
865                 870                 875                 880 


Gly Gly Lys Asp Gly Ile Val Ala Leu Trp Asp Asp Ser Phe Glu Arg 
                885                 890                 895     


Cys Leu Lys Thr Tyr Ala Ile Lys Arg Ala Ala Leu Ala Pro Gly Ser 
            900                 905                 910         


Lys Gly Leu Leu Leu Glu Asp Asn Pro Ser Ile Arg Ala Ile Ser Leu 
        915                 920                 925             


Gly His Gly His Ile Leu Val Gly Thr Lys Asn Gly Glu Ile Leu Glu 
    930                 935                 940                 


Val Asp Lys Ser Gly Pro Ile Thr Leu Leu Val Gln Gly His Met Glu 
945                 950                 955                 960 


Gly Glu Val Trp Gly Leu Ala Thr His Pro Tyr Leu Pro Ile Cys Ala 
                965                 970                 975     


Thr Val Ser Asp Asp Lys Thr Leu Arg Ile Trp Asp Leu Ser Pro Ser 
            980                 985                 990         


His Cys Met Leu Ala Val Arg Lys  Leu Lys Lys Gly Gly  Arg Cys Cys 
        995                 1000                 1005             


Cys Phe  Ser Pro Asp Gly Lys  Ala Leu Ala Val Gly  Leu Asn Asp 
    1010                 1015                 1020             


Gly Ser  Phe Leu Met Ala Asn  Ala Asp Thr Leu Glu  Asp Leu Val 
    1025                 1030                 1035             


Ser Phe  His His Arg Lys Asp  Met Ile Ser Asp Ile  Arg Phe Ser 
    1040                 1045                 1050             


Pro Gly  Ser Gly Lys Tyr Leu  Ala Val Ala Ser His  Asp Ser Phe 
    1055                 1060                 1065             


Ile Asp  Ile Tyr Asn Val Met  Ser Ser Lys Arg Val  Gly Ile Cys 
    1070                 1075                 1080             


Lys Gly  Ala Thr Ser Tyr Ile  Thr His Ile Asp Trp  Asp Ile Arg 
    1085                 1090                 1095             


Gly Lys  Leu Leu Gln Val Asn  Thr Gly Ala Lys Glu  Gln Leu Phe 
    1100                 1105                 1110             


Phe Glu  Ala Pro Arg Gly Lys  Lys Gln Thr Ile Pro  Ser Val Glu 
    1115                 1120                 1125             


Val Glu  Lys Ile Ala Trp Ala  Ser Trp Thr Ser Val  Leu Gly Leu 
    1130                 1135                 1140             


Cys Cys  Glu Gly Ile Trp Pro  Val Ile Gly Glu Val  Thr Asp Val 
    1145                 1150                 1155             


Thr Ala  Ser Cys Leu Thr Ser  Asp Lys Met Val Leu  Ala Thr Gly 
    1160                 1165                 1170             


Asp Asp  Leu Gly Phe Val Lys  Leu Phe Arg Tyr Pro  Thr Lys Gly 
    1175                 1180                 1185             


Lys Phe  Gly Lys Phe Lys Arg  Tyr Val Ala His Ser  Thr His Val 
    1190                 1195                 1200             


Thr Asn  Val Arg Trp Thr Tyr  Asp Asp Ser Met Leu  Val Thr Leu 
    1205                 1210                 1215             


Gly Gly  Thr Asp Met Ser Leu  Met Val Trp Thr Asn  Glu Met Glu 
    1220                 1225                 1230             


Gly Tyr  Arg Glu Lys Arg Pro  Cys Asp Ser Glu Glu  Ser Asp Ile 
    1235                 1240                 1245             


Asp Ser  Glu Glu Asp Gly Gly  Tyr Asp Ser Asp Val  Thr Arg Glu 
    1250                 1255                 1260             


Asn Glu  Ile Ser Tyr Thr Ile  Arg Ala Leu Ser Thr  Asn Ile Arg 
    1265                 1270                 1275             


Pro Met  Leu Gly Ile Lys Pro  His Leu Gln Gln Lys  Glu Pro Ser 
    1280                 1285                 1290             


Ile Asp  Glu Arg Pro Pro Val  Ser Arg Ala Pro Pro  Gln Pro Glu 
    1295                 1300                 1305             


Lys Leu  Gln Thr Asn Asn Val  Gly Lys Lys Lys Arg  Pro Ile Glu 
    1310                 1315                 1320             


Asp Leu  Val Leu Glu Leu Ile  Phe Gly Tyr Arg Gly  Arg Asp Cys 
    1325                 1330                 1335             


Arg Asn  Asn Val His Tyr Leu  Asn Asp Gly Asp Asp  Ile Ile Tyr 
    1340                 1345                 1350             


His Thr  Ala Ser Val Gly Ile  Leu His Asn Val Ala  Thr Gly Ser 
    1355                 1360                 1365             


Gln Ser  Phe Tyr Gln Glu His  Asn Asp Asp Ile Leu  Cys Leu Thr 
    1370                 1375                 1380             


Val Asn  Gln His Pro Lys Phe  Ile Asn Ile Val Ala  Thr Gly Gln 
    1385                 1390                 1395             


Val Val  Leu Ser Cys Ser Leu  Leu Thr Thr Ala Pro  Ser Ile His 
    1400                 1405                 1410             


Ile Trp  Asp Ala Met Asn Lys  Gln Thr Leu Ser Ile  Leu Arg Cys 
    1415                 1420                 1425             


Tyr His  Ser Lys Gly Val Cys  Ser Val Ser Phe Ser  Ala Thr Gly 
    1430                 1435                 1440             


Lys Leu  Leu Leu Ser Val Gly  Leu Asp Pro Glu His  Thr Ile Thr 
    1445                 1450                 1455             


Ile Trp  Arg Trp Gln Glu Gly  Ala Lys Ile Ala Ser  Arg Ala Gly 
    1460                 1465                 1470             


His Asn  Gln Arg Ile Phe Val  Ala Glu Phe Arg Pro  Asp Ser Asp 
    1475                 1480                 1485             


Thr Gln  Phe Val Ser Val Gly  Val Lys His Val Lys  Phe Trp Thr 
    1490                 1495                 1500             


Leu Ala  Gly Arg Ala Leu Leu  Ser Lys Lys Gly Leu  Leu Ser Thr 
    1505                 1510                 1515             


Leu Glu  Asp Ala Arg Met Gln  Thr Met Leu Ala Ile  Ala Phe Gly 
    1520                 1525                 1530             


Ala Asn  Asn Leu Thr Phe Thr  Gly Thr Ile Ser Gly  Asp Val Cys 
    1535                 1540                 1545             


Val Trp  Lys Asp His Ile Leu  Cys Arg Ile Val Ala  Arg Ala His 
    1550                 1555                 1560             


Asn Gly  Pro Val Phe Ala Met  Tyr Thr Thr Leu Arg  Asp Gly Leu 
    1565                 1570                 1575             


Ile Val  Thr Gly Gly Lys Glu  Arg Pro Ser Lys Glu  Gly Gly Ala 
    1580                 1585                 1590             


Val Lys  Leu Trp Asp Gln Glu  Leu Arg Arg Cys Arg  Ala Phe Arg 
    1595                 1600                 1605             


Leu Glu  Thr Gly Gln Ala Thr  Asp Cys Val Arg Ser  Val Cys Arg 
    1610                 1615                 1620             


Gly Lys  Gly Lys Ile Leu Val  Gly Thr Arg Asn Ala  Glu Ile Ile 
    1625                 1630                 1635             


Glu Val  Gly Glu Lys Asn Ala  Ala Cys Asn Ile Leu  Val Asn Gly 
    1640                 1645                 1650             


His Val  Asp Gly Pro Ile Trp  Gly Leu Ala Thr His  Pro Ser Arg 
    1655                 1660                 1665             


Asp Phe  Phe Leu Ser Ala Ala  Glu Asp Gly Thr Val  Arg Leu Trp 
    1670                 1675                 1680             


Asp Ile  Ala Asp Lys Lys Met  Leu Asn Lys Val Asn  Leu Gly His 
    1685                 1690                 1695             


Ala Ala  Arg Thr Val Cys Tyr  Ser Pro Glu Gly Asp  Met Val Ala 
    1700                 1705                 1710             


Ile Gly  Met Lys Asn Gly Glu  Phe Ile Ile Leu Leu  Val Ser Ser 
    1715                 1720                 1725             


Leu Lys  Ile Trp Gly Lys Lys  Arg Asp Arg Arg Cys  Ala Ile His 
    1730                 1735                 1740             


Asp Ile  Arg Phe Ser Pro Asp  Ser Arg Tyr Leu Ala  Val Gly Ser 
    1745                 1750                 1755             


Ser Glu  Asn Ser Val Asp Phe  Tyr Asp Leu Thr Leu  Gly Pro Thr 
    1760                 1765                 1770             


Leu Asn  Arg Ile Ser Tyr Cys  Lys Asp Ile Pro Ser  Phe Val Ile 
    1775                 1780                 1785             


Gln Met  Asp Phe Ser Ala Asp  Ser Ser Tyr Leu Gln  Val Ser Ser 
    1790                 1795                 1800             


Gly Cys  Tyr Lys Arg His Val  Tyr Glu Val Pro Ser  Gly Lys His 
    1805                 1810                 1815             


Leu Met  Asp His Ala Ala Ile  Asp Arg Ile Thr Trp  Ala Thr Trp 
    1820                 1825                 1830             


Thr Ser  Ile Leu Gly Asp Glu  Val Leu Gly Ile Trp  Ser Arg His 
    1835                 1840                 1845             


Ala Glu  Lys Ala Asp Val Asn  Cys Ala Cys Val Ser  His Ser Gly 
    1850                 1855                 1860             


Ile Ser  Leu Val Thr Gly Asp  Asp Phe Gly Met Val  Lys Leu Phe 
    1865                 1870                 1875             


Asp Phe  Pro Cys Pro Glu Lys  Phe Ala Lys His Lys  Arg Phe Leu 
    1880                 1885                 1890             


Gly His  Ser Pro His Val Thr  Asn Ile Arg Phe Thr  Ser Gly Asp 
    1895                 1900                 1905             


Arg His  Val Val Ser Ala Gly  Gly Asp Asp Cys Ser  Leu Phe Val 
    1910                 1915                 1920             


Trp Lys  Cys Val His Thr Pro  His 
    1925                 1930     


<210> 5835
<211> 142
<212> PRT
<213> Homo sapiens

<400> 5835
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln Thr Arg Gln 
                85                  90                  95      


Gln Ala Tyr Arg Asp Lys Leu Ala Gln Gln Gln Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ser Gln Gln Gly Ser Ala Lys Asn Gly Glu 
        115                 120                 125             


Asn Thr Ala Asn Gly Glu Glu Asn Gly Ala His Thr Ile Ala 
    130                 135                 140         


<210> 5836
<211> 567
<212> PRT
<213> Homo sapiens

<400> 5836
Met Glu Phe Phe Thr Met Pro Pro Arg Thr Trp Phe Met Arg Gln Leu 
1               5                   10                  15      


Gln Arg Met Trp Phe Leu Arg Pro Ser Met Ala Ile Met Val Phe Arg 
            20                  25                  30          


Met Ile Glu Glu Arg Pro Thr His Ala Ile Thr Val Arg Val Ser Tyr 
        35                  40                  45              


Leu Glu Ile Tyr Asn Glu Ser Leu Phe Asp Leu Leu Ser Thr Leu Pro 
    50                  55                  60                  


Tyr Val Gly Pro Ser Val Thr Pro Met Thr Ile Val Glu Asn Pro Gln 
65                  70                  75                  80  


Gly Val Phe Ile Lys Gly Leu Ser Val His Leu Thr Ser Gln Glu Glu 
                85                  90                  95      


Asp Ala Phe Ser Leu Leu Phe Glu Gly Glu Thr Asn Arg Ile Ile Ala 
            100                 105                 110         


Ser His Thr Met Asn Lys Asn Ser Ser Arg Ser His Cys Ile Phe Thr 
        115                 120                 125             


Ile Tyr Leu Glu Ala His Ser Arg Thr Leu Ser Glu Glu Lys Tyr Ile 
    130                 135                 140                 


Thr Ser Lys Ile Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Glu Gly Gln Val Leu Lys Glu Ala Thr Tyr Ile Asn 
                165                 170                 175     


Lys Ser Leu Ser Phe Leu Glu Gln Ala Ile Ile Ala Leu Gly Asp Gln 
            180                 185                 190         


Lys Arg Asp His Ile Pro Phe Arg Gln Cys Lys Leu Thr His Ala Leu 
        195                 200                 205             


Lys Asp Ser Leu Gly Gly Asn Cys Asn Met Val Leu Val Thr Asn Ile 
    210                 215                 220                 


Tyr Gly Glu Ala Ala Gln Leu Glu Glu Thr Leu Ser Ser Leu Arg Phe 
225                 230                 235                 240 


Ala Ser Arg Met Lys Leu Val Thr Thr Glu Pro Ala Ile Asn Glu Lys 
                245                 250                 255     


Tyr Asp Ala Glu Arg Met Val Lys Asn Leu Glu Lys Glu Leu Ala Leu 
            260                 265                 270         


Leu Lys Gln Glu Leu Ala Ile His Asp Ser Leu Thr Asn Arg Thr Phe 
        275                 280                 285             


Val Thr Tyr Asp Pro Met Asp Glu Ile Gln Ile Ala Glu Ile Asn Ser 
    290                 295                 300                 


Gln Val Arg Arg Tyr Leu Glu Gly Thr Leu Asp Glu Ile Asp Ile Ile 
305                 310                 315                 320 


Ser Leu Arg Gln Ile Lys Glu Val Phe Asn Gln Phe Arg Val Val Leu 
                325                 330                 335     


Ser Gln Gln Glu Gln Glu Val Glu Ser Thr Leu Arg Arg Lys Tyr Thr 
            340                 345                 350         


Leu Ile Asp Arg Asn Asp Phe Ala Ala Ile Ser Ala Ile Gln Lys Ala 
        355                 360                 365             


Gly Leu Val Asp Val Asp Gly His Leu Val Gly Glu Pro Glu Gly Gln 
    370                 375                 380                 


Asn Phe Gly Leu Gly Val Ala Pro Phe Ser Thr Lys Pro Gly Lys Lys 
385                 390                 395                 400 


Ala Lys Ser Lys Lys Thr Phe Lys Glu Pro Leu Arg Pro Asp Thr Pro 
                405                 410                 415     


Pro Ser Lys Pro Val Ala Phe Glu Glu Phe Lys Asn Glu Gln Gly Ser 
            420                 425                 430         


Glu Ile Asn Arg Ile Phe Lys Glu Asn Lys Ser Ile Leu Asn Glu Arg 
        435                 440                 445             


Arg Lys Arg Ala Ser Glu Thr Thr Gln His Ile Asn Ala Ile Lys Arg 
    450                 455                 460                 


Glu Ile Asp Val Thr Lys Glu Ala Leu Asn Phe Gln Lys Ser Leu Arg 
465                 470                 475                 480 


Glu Lys Gln Gly Lys Tyr Glu Asn Lys Gly Leu Met Ile Ile Asp Glu 
                485                 490                 495     


Glu Glu Phe Leu Leu Ile Leu Lys Leu Lys Asp Leu Lys Lys Gln Tyr 
            500                 505                 510         


Arg Ser Glu Tyr Gln Asp Leu Arg Asp Leu Arg Ala Glu Ile Gln Tyr 
        515                 520                 525             


Cys Gln His Leu Val Asp Gln Cys Arg His Arg Leu Leu Met Gly Ala 
    530                 535                 540                 


Thr Val Gly Lys Asn Leu Thr Ser Gly Thr Met Ser Pro Leu Ser Ser 
545                 550                 555                 560 


Leu Arg Thr Cys Arg Trp His 
                565         


<210> 5837
<211> 475
<212> PRT
<213> Homo sapiens

<400> 5837
Met Ala Glu Gly Ser Val Met Phe Ser Asp Val Ser Ile Asp Phe Ser 
1               5                   10                  15      


Gln Glu Glu Trp Asp Cys Leu Asp Pro Val Gln Arg Asp Leu Tyr Arg 
            20                  25                  30          


Asp Val Met Leu Glu Asn Tyr Gly Asn Leu Val Ser Met Gly Leu Tyr 
        35                  40                  45              


Thr Pro Lys Pro Gln Val Ile Ser Leu Leu Glu Gln Gly Lys Glu Pro 
    50                  55                  60                  


Trp Met Val Gly Arg Glu Leu Thr Arg Gly Leu Cys Ser Asp Leu Glu 
65                  70                  75                  80  


Ser Met Cys Glu Thr Lys Leu Leu Ser Leu Lys Lys Glu Val Tyr Glu 
                85                  90                  95      


Ile Glu Leu Cys Gln Arg Glu Ile Met Gly Leu Thr Lys His Gly Leu 
            100                 105                 110         


Glu Tyr Ser Ser Phe Gly Asp Val Leu Glu Tyr Arg Ser His Leu Ala 
        115                 120                 125             


Lys Gln Leu Gly Tyr Pro Asn Gly His Phe Ser Gln Glu Ile Phe Thr 
    130                 135                 140                 


Pro Glu Tyr Met Pro Thr Phe Ile Gln Gln Thr Phe Leu Thr Leu His 
145                 150                 155                 160 


Gln Ile Ile Asn Asn Glu Asp Arg Pro Tyr Glu Cys Lys Lys Cys Gly 
                165                 170                 175     


Lys Ala Phe Ser Gln Asn Ser Gln Phe Ile Gln His Gln Arg Ile His 
            180                 185                 190         


Ile Gly Glu Lys Ser Tyr Glu Cys Lys Glu Cys Gly Lys Phe Phe Ser 
        195                 200                 205             


Cys Gly Ser His Val Thr Arg His Leu Lys Ile His Thr Gly Glu Lys 
    210                 215                 220                 


Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Cys Ser Ser Tyr 
225                 230                 235                 240 


Leu Ser Gln His Gln Arg Ile His Thr Gly Lys Lys Pro Tyr Glu Cys 
                245                 250                 255     


Lys Glu Cys Gly Lys Ala Phe Ser Tyr Cys Ser Asn Leu Ile Asp His 
            260                 265                 270         


Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Val Cys Gly 
        275                 280                 285             


Lys Ala Phe Thr Lys Ser Ser Gln Leu Phe Gln His Ala Arg Ile His 
    290                 295                 300                 


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Thr 
305                 310                 315                 320 


Gln Ser Ser Lys Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys 
                325                 330                 335     


Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser Gly Ser Ala 
            340                 345                 350         


Leu Thr Asn His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Asp Cys 
        355                 360                 365             


Lys Glu Cys Gly Lys Ala Phe Thr Gln Ser Ser Gln Leu Arg Gln His 
    370                 375                 380                 


Gln Arg Ile His Ala Gly Glu Lys Pro Phe Glu Cys Leu Glu Cys Gly 
385                 390                 395                 400 


Lys Ala Phe Thr Gln Asn Ser Gln Leu Phe Gln His Gln Arg Ile His 
                405                 410                 415     


Thr Asp Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Asn 
            420                 425                 430         


Lys Cys Ser Asn Leu Thr Arg His Leu Arg Ile His Thr Gly Glu Lys 
        435                 440                 445             


Pro Tyr Asn Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser Gly Ser Asp 
    450                 455                 460                 


Leu Ile Arg His Gln Gly Ile His Thr Asn Lys 
465                 470                 475 


<210> 5838
<211> 153
<212> PRT
<213> Homo sapiens

<400> 5838
Met Ala Arg Asn Thr Leu Ser Ser Arg Phe Arg Arg Val Asp Ile Asp 
1               5                   10                  15      


Glu Phe Asp Glu Asn Lys Phe Val Asp Glu Gln Glu Glu Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Glu Pro Gly Pro Asp Pro Ser Glu Val Asp Gly Leu Leu 
        35                  40                  45              


Arg Gln Gly Asp Met Leu Arg Ala Phe His Ala Ala Leu Arg Asn Ser 
    50                  55                  60                  


Pro Val Asn Thr Lys Asn Gln Ala Val Lys Glu Arg Ala Gln Gly Val 
65                  70                  75                  80  


Val Leu Lys Val Leu Thr Asn Phe Lys Ser Ser Glu Ile Glu Gln Ala 
                85                  90                  95      


Val Gln Ser Leu Asp Arg Asn Gly Val Asp Leu Leu Met Lys Tyr Ile 
            100                 105                 110         


Tyr Lys Gly Phe Glu Lys Pro Thr Glu Asn Ser Ser Ala Val Leu Leu 
        115                 120                 125             


Gln Trp His Glu Lys Ala Leu Ala Val Gly Gly Leu Gly Ser Ile Ile 
    130                 135                 140                 


Arg Val Leu Thr Ala Arg Lys Thr Val 
145                 150             


<210> 5839
<211> 871
<212> PRT
<213> Homo sapiens

<400> 5839
Met Gly Glu Gly Gly Leu Pro Pro Ala Phe Gln Leu Leu Leu Arg Ala 
1               5                   10                  15      


Cys Asp Gln Gly Asp Thr Glu Thr Ala Arg Arg Leu Leu Glu Pro Gly 
            20                  25                  30          


Ala Ala Glu Pro Ala Glu Arg Gly Ala Glu Pro Glu Ala Gly Ala Glu 
        35                  40                  45              


Pro Ala Gly Ala Glu Val Ala Gly Pro Gly Ala Ala Ala Ala Gly Ala 
    50                  55                  60                  


Val Gly Ala Pro Val Pro Val Asp Cys Ser Asp Glu Ala Gly Asn Thr 
65                  70                  75                  80  


Ala Leu Gln Phe Ala Ala Ala Gly Gly His Glu Pro Leu Val Arg Phe 
                85                  90                  95      


Leu Leu Arg Arg Gly Ala Ser Val Asn Ser Arg Asn His Tyr Gly Trp 
            100                 105                 110         


Ser Ala Leu Met Gln Ala Ala Arg Phe Gly His Val Ser Val Ala His 
        115                 120                 125             


Leu Leu Leu Asp His Gly Ala Asp Val Asn Ala Gln Asn Arg Leu Gly 
    130                 135                 140                 


Ala Ser Val Leu Thr Val Ala Ser Arg Gly Gly His Leu Gly Val Val 
145                 150                 155                 160 


Lys Leu Leu Leu Glu Ala Gly Ala Phe Val Asp His His His Pro Ser 
                165                 170                 175     


Gly Glu Gln Leu Gly Leu Gly Gly Ser Arg Asp Glu Pro Leu Asp Ile 
            180                 185                 190         


Thr Ala Leu Met Ala Ala Ile Gln His Gly His Glu Ala Val Val Arg 
        195                 200                 205             


Leu Leu Met Glu Trp Gly Ala Asp Pro Asn His Ala Ala Arg Thr Val 
    210                 215                 220                 


Gly Trp Ser Pro Leu Met Leu Ala Ala Leu Thr Gly Arg Leu Gly Val 
225                 230                 235                 240 


Ala Gln Gln Leu Val Glu Lys Gly Ala Asn Pro Asp His Leu Ser Val 
                245                 250                 255     


Leu Glu Lys Thr Ala Phe Glu Val Ala Leu Asp Cys Lys His Arg Asp 
            260                 265                 270         


Leu Val Asp Tyr Leu Asp Pro Leu Thr Thr Val Arg Pro Lys Thr Asp 
        275                 280                 285             


Glu Glu Lys Arg Arg Pro Asp Ile Phe His Ala Leu Lys Met Gly Asn 
    290                 295                 300                 


Phe Gln Leu Val Lys Glu Ile Ala Asp Glu Asp Pro Ser His Val Asn 
305                 310                 315                 320 


Leu Val Asn Gly Asp Gly Ala Thr Pro Leu Met Leu Ala Ala Val Thr 
                325                 330                 335     


Gly Gln Leu Ala Leu Val Gln Leu Leu Val Glu Arg His Ala Asp Val 
            340                 345                 350         


Asp Lys Gln Asp Ser Val His Gly Trp Thr Ala Leu Met Gln Ala Thr 
        355                 360                 365             


Tyr His Gly Asn Lys Glu Ile Val Lys Tyr Leu Leu Asn Gln Gly Ala 
    370                 375                 380                 


Asp Val Thr Leu Arg Ala Lys Asn Gly Tyr Thr Ala Phe Asp Leu Val 
385                 390                 395                 400 


Met Leu Leu Asn Asp Pro Asp Thr Glu Leu Val Arg Leu Leu Ala Ser 
                405                 410                 415     


Val Cys Met Gln Val Asn Lys Asp Lys Gly Arg Pro Ser His Gln Pro 
            420                 425                 430         


Pro Leu Pro His Ser Lys Val Arg Gln Pro Trp Ser Ile Pro Val Leu 
        435                 440                 445             


Pro Asp Asp Lys Gly Gly Leu Lys Ser Trp Trp Asn Arg Met Ser Asn 
    450                 455                 460                 


Arg Phe Arg Lys Leu Lys Leu Met Gln Thr Leu Pro Arg Gly Leu Ser 
465                 470                 475                 480 


Ser Asn Gln Pro Leu Pro Phe Ser Asp Glu Pro Glu Pro Ala Leu Asp 
                485                 490                 495     


Ser Thr Met Arg Ala Ala Pro Gln Asp Lys Thr Ser Arg Ser Ala Leu 
            500                 505                 510         


Pro Asp Ala Ala Pro Val Thr Lys Asp Asn Gly Pro Gly Ser Thr Arg 
        515                 520                 525             


Gly Glu Lys Glu Asp Thr Leu Leu Thr Thr Met Leu Arg Asn Gly Ala 
    530                 535                 540                 


Pro Leu Thr Arg Leu Pro Ser Asp Lys Leu Lys Ala Val Ile Pro Pro 
545                 550                 555                 560 


Phe Leu Pro Pro Ser Ser Phe Glu Leu Trp Ser Ser Asp Arg Ser Arg 
                565                 570                 575     


Thr Arg His Asn Gly Lys Ala Asp Pro Met Lys Thr Ala Leu Pro Gln 
            580                 585                 590         


Arg Ala Ser Arg Gly His Pro Val Gly Gly Gly Gly Thr Asp Thr Thr 
        595                 600                 605             


Pro Val Arg Pro Val Lys Phe Pro Ser Leu Pro Arg Ser Pro Ala Ser 
    610                 615                 620                 


Ser Ala Asn Ser Gly Asn Phe Asn His Ser Pro His Ser Ser Gly Gly 
625                 630                 635                 640 


Ser Ser Gly Val Gly Val Ser Arg His Gly Gly Glu Leu Leu Asn Arg 
                645                 650                 655     


Ser Gly Gly Ser Ile Asp Asn Val Leu Ser Gln Ile Ala Ala Gln Arg 
            660                 665                 670         


Lys Lys Ala Ala Gly Leu Leu Glu Gln Lys Pro Ser His Arg Ser Ser 
        675                 680                 685             


Pro Val Gly Pro Ala Pro Gly Ser Ser Pro Ser Glu Leu Pro Ala Ser 
    690                 695                 700                 


Pro Ala Gly Gly Ser Ala Pro Val Gly Lys Lys Leu Glu Thr Ser Lys 
705                 710                 715                 720 


Arg Pro Pro Ser Gly Thr Ser Thr Thr Ser Lys Ser Thr Ser Pro Thr 
                725                 730                 735     


Leu Thr Pro Ser Pro Ser Pro Lys Gly His Thr Ala Glu Ser Ser Val 
            740                 745                 750         


Ser Ser Ser Ser Ser His Arg Gln Ser Lys Ser Ser Gly Gly Ser Ser 
        755                 760                 765             


Ser Gly Thr Ile Thr Asp Glu Asp Glu Leu Thr Gly Ile Leu Lys Lys 
    770                 775                 780                 


Leu Ser Leu Glu Lys Tyr Gln Pro Ile Phe Glu Glu Gln Glu Val Asp 
785                 790                 795                 800 


Met Glu Ala Phe Leu Thr Leu Thr Asp Gly Asp Leu Lys Glu Leu Gly 
                805                 810                 815     


Ile Lys Thr Asp Gly Ser Arg Gln Gln Ile Leu Ala Ala Ile Ser Glu 
            820                 825                 830         


Leu Asn Ala Gly Lys Gly Arg Glu Arg Gln Ile Leu Gln Glu Thr Ile 
        835                 840                 845             


His Asn Phe His Ser Ser Phe Glu Ser Ser Ala Ser Asn Thr Arg Ala 
    850                 855                 860                 


Pro Gly Asn Ser Pro Cys Ala 
865                 870     


<210> 5840
<211> 452
<212> PRT
<213> Homo sapiens

<400> 5840
Met Ser Ala Ser Leu Asn Tyr Lys Ser Phe Ser Lys Glu Gln Gln Thr 
1               5                   10                  15      


Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
            20                  25                  30          


Phe Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
        35                  40                  45              


Lys Cys Ala Ser Asp Ile Phe Gln Ala Ser Asn Pro Tyr Leu Pro Thr 
    50                  55                  60                  


Arg Gly Gly Thr Thr Met Ala Ser Gly Gly Arg Phe Arg Cys Pro Ser 
65                  70                  75                  80  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
                85                  90                  95      


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
            100                 105                 110         


Thr Arg Pro Glu Lys Lys Ser Asp Gln Pro Met Cys Glu Glu His Glu 
        115                 120                 125             


Glu Glu Arg Ile Asn Ile Tyr Cys Leu Asn Cys Glu Val Pro Thr Cys 
    130                 135                 140                 


Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Gln Val Ala Pro 
145                 150                 155                 160 


Leu Thr His Val Phe Gln Arg Gln Lys Ser Glu Leu Ser Asp Gly Ile 
                165                 170                 175     


Ala Ile Leu Val Gly Ser Asn Asp Arg Val Gln Gly Val Ile Ser Gln 
            180                 185                 190         


Leu Glu Asp Thr Cys Lys Thr Ile Glu Glu Cys Cys Arg Lys Gln Lys 
        195                 200                 205             


Gln Glu Leu Cys Glu Lys Phe Asp Tyr Leu Tyr Gly Ile Leu Glu Glu 
    210                 215                 220                 


Arg Lys Asn Glu Met Thr Gln Val Ile Thr Arg Thr Gln Glu Glu Lys 
225                 230                 235                 240 


Leu Glu His Val Arg Ala Leu Ile Lys Lys Tyr Ser Asp His Leu Glu 
                245                 250                 255     


Asn Val Ser Lys Leu Val Glu Ser Gly Ile Gln Phe Met Asp Glu Pro 
            260                 265                 270         


Glu Met Ala Val Phe Leu Gln Asn Ala Lys Thr Leu Leu Lys Lys Ile 
        275                 280                 285             


Ser Glu Ala Ser Lys Ala Phe Gln Met Glu Lys Ile Glu His Gly Tyr 
    290                 295                 300                 


Glu Asn Met Asn His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys Ile 
305                 310                 315                 320 


Ile Arg Glu Ile Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu 
                325                 330                 335     


Glu Gly Gly Glu Gly Glu Lys Glu Gly Glu Gly Glu Val Gly Gly Glu 
            340                 345                 350         


Ala Val Glu Val Glu Glu Val Glu Asn Val Gln Thr Glu Phe Pro Gly 
        355                 360                 365             


Glu Asp Glu Asn Pro Glu Lys Ala Ser Glu Leu Ser Gln Val Glu Leu 
    370                 375                 380                 


Gln Ala Ala Pro Gly Ala Leu Pro Val Ser Ser Pro Glu Pro Pro Pro 
385                 390                 395                 400 


Ala Leu Pro Pro Ala Ala Asp Ala Pro Val Thr Gln Ile Gly Phe Glu 
                405                 410                 415     


Ala Pro Pro Leu Gln Gly Gln Ala Ala Ala Pro Ala Ser Gly Ser Gly 
            420                 425                 430         


Ala Asp Ser Glu Pro Ala Arg His Ile Phe Ser Phe Ser Trp Leu Asn 
        435                 440                 445             


Ser Leu Asn Glu 
    450         


<210> 5841
<211> 163
<212> PRT
<213> Homo sapiens

<400> 5841
Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30          


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45              


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60                  


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80  


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95      


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110         


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125             


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140                 


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160 


Glu Glu Lys 
            


<210> 5842
<211> 399
<212> PRT
<213> Homo sapiens

<400> 5842
Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro 
            20                  25                  30          


Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe 
        35                  40                  45              


Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn 
    50                  55                  60                  


Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser 
65                  70                  75                  80  


Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp 
                85                  90                  95      


Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala 
            100                 105                 110         


Tyr Gly Ser Val Asn Lys Met Val His Lys Pro Ser Gly Gln Ile Met 
        115                 120                 125             


Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln 
    130                 135                 140                 


Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr 
145                 150                 155                 160 


Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile 
                165                 170                 175     


Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val 
            180                 185                 190         


Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile 
        195                 200                 205             


Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys 
    210                 215                 220                 


Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser 
225                 230                 235                 240 


Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp 
                245                 250                 255     


Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro 
            260                 265                 270         


Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser 
        275                 280                 285             


Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg 
    290                 295                 300                 


Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val 
305                 310                 315                 320 


Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe 
                325                 330                 335     


Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu 
            340                 345                 350         


Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu 
        355                 360                 365             


Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile 
    370                 375                 380                 


Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
385                 390                 395                 


<210> 5843
<211> 373
<212> PRT
<213> Homo sapiens

<400> 5843
Met Ala Gln Glu Ser Pro Lys Asn Ser Ala Ala Glu Ile Pro Val Thr 
1               5                   10                  15      


Ser Asn Gly Glu Val Asp Asp Ser Arg Glu His Ser Phe Asn Arg Asp 
            20                  25                  30          


Leu Lys His Ser Leu Pro Ser Gly Leu Gly Leu Ser Glu Thr Gln Ile 
        35                  40                  45              


Thr Ser His Gly Phe Asp Asn Thr Lys Glu Gly Val Ile Glu Ala Gly 
    50                  55                  60                  


Ala Phe Gln Gly Ser Pro Ala Pro Pro Leu Pro Ser Val Met Ser Pro 
65                  70                  75                  80  


Ser Arg Val Ala Ala Ser Arg Leu Ala Gln Gln Gly Ser Asp Leu Ile 
                85                  90                  95      


Val Pro Ala Gly Gly Gln Arg Thr Gln Thr Lys Ser Gly Pro Val Ile 
            100                 105                 110         


Leu Ala Asp Glu Ile Lys Asn Pro Ala Met Glu Lys Leu Glu Leu Val 
        115                 120                 125             


Arg Lys Trp Ser Leu Asn Thr Tyr Lys Cys Thr Arg Gln Ile Ile Ser 
    130                 135                 140                 


Glu Lys Leu Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Ala 
145                 150                 155                 160 


Gln Ile Asp Ile Leu Arg Asp Asn Lys Lys Lys Tyr Glu Asn Ile Leu 
                165                 170                 175     


Lys Leu Ala Gln Thr Leu Ser Thr Gln Leu Phe Gln Met Val His Thr 
            180                 185                 190         


Gln Arg Gln Leu Gly Asp Ala Phe Ala Asp Leu Ser Leu Lys Ser Leu 
        195                 200                 205             


Glu Leu His Glu Glu Phe Gly Tyr Asn Ala Asp Thr Gln Lys Leu Leu 
    210                 215                 220                 


Ala Lys Asn Gly Glu Thr Leu Leu Gly Ala Ile Asn Phe Phe Ile Ala 
225                 230                 235                 240 


Ser Val Asn Thr Leu Val Asn Lys Thr Ile Glu Asp Thr Leu Met Thr 
                245                 250                 255     


Val Lys Gln Tyr Glu Ser Ala Arg Ile Glu Tyr Asp Ala Tyr Arg Thr 
            260                 265                 270         


Asp Leu Glu Glu Leu Asn Leu Gly Pro Arg Asp Ala Asn Thr Leu Pro 
        275                 280                 285             


Lys Ile Glu Gln Ser Gln His Leu Phe Gln Ala His Lys Glu Lys Tyr 
    290                 295                 300                 


Asp Lys Met Arg Asn Asp Val Ser Val Lys Leu Lys Phe Leu Glu Glu 
305                 310                 315                 320 


Asn Lys Val Lys Val Leu His Asn Gln Leu Val Leu Phe His Asn Ala 
                325                 330                 335     


Ile Ala Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
            340                 345                 350         


Lys Gln Phe His Ile Lys Leu Lys Thr Pro Gly Val Asp Ala Pro Ser 
        355                 360                 365             


Trp Leu Glu Glu Gln 
    370             


<210> 5844
<211> 217
<212> PRT
<213> Homo sapiens

<400> 5844
Met Tyr Ser Leu Asn Gln Glu Ile Lys Ala Phe Ser Arg Asn Asn Leu 
1               5                   10                  15      


Arg Lys Gln Cys Thr Arg Val Thr Thr Leu Thr Gly Lys Lys Ile Ile 
            20                  25                  30          


Glu Thr Trp Lys Asp Ala Arg Ile His Val Val Glu Glu Val Glu Pro 
        35                  40                  45              


Ser Ser Gly Gly Gly Cys Gly Tyr Val Gln Asp Leu Ser Ser Asp Leu 
    50                  55                  60                  


Gln Val Gly Val Ile Lys Pro Trp Leu Leu Leu Gly Ser Gln Asp Ala 
65                  70                  75                  80  


Ala His Asp Leu Asp Thr Leu Lys Lys Asn Lys Val Thr His Ile Leu 
                85                  90                  95      


Asn Val Ala Tyr Gly Val Glu Asn Ala Phe Leu Ser Asp Phe Thr Tyr 
            100                 105                 110         


Lys Ser Ile Ser Ile Leu Asp Leu Pro Glu Thr Asn Ile Leu Ser Tyr 
        115                 120                 125             


Phe Pro Glu Cys Phe Glu Phe Ile Glu Glu Ala Lys Arg Lys Asp Gly 
    130                 135                 140                 


Val Val Leu Val His Cys Asn Ala Gly Val Ser Arg Ala Ala Ala Ile 
145                 150                 155                 160 


Val Ile Gly Phe Leu Met Asn Ser Glu Gln Thr Ser Phe Thr Ser Ala 
                165                 170                 175     


Phe Ser Leu Val Lys Asn Ala Arg Pro Ser Ile Cys Pro Asn Ser Gly 
            180                 185                 190         


Phe Met Glu Gln Leu Arg Thr Tyr Gln Glu Gly Lys Glu Ser Asn Lys 
        195                 200                 205             


Cys Asp Arg Ile Gln Glu Asn Ser Ser 
    210                 215         


<210> 5845
<211> 892
<212> PRT
<213> Homo sapiens

<400> 5845
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Cys Trp Met 
    850                 855                 860                 


Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala Ala 
865                 870                 875                 880 


Leu Arg Val Thr Lys Pro Tyr Leu Asp Ile Gly Cys 
                885                 890         


<210> 5846
<211> 314
<212> PRT
<213> Homo sapiens

<400> 5846
Met Gln Thr Phe Leu Lys Gly Lys Arg Val Gly Tyr Trp Leu Ser Glu 
1               5                   10                  15      


Lys Lys Ile Lys Lys Leu Asn Phe Gln Ala Phe Ala Glu Leu Cys Arg 
            20                  25                  30          


Lys Arg Gly Met Glu Val Val Gln Leu Asn Leu Ser Arg Pro Ile Glu 
        35                  40                  45              


Glu Gln Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile 
    50                  55                  60                  


Leu Glu Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg 
65                  70                  75                  80  


Phe Gln Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro 
                85                  90                  95      


Leu Pro Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu 
            100                 105                 110         


Ile Arg Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro 
        115                 120                 125             


Pro Phe Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu 
    130                 135                 140                 


Leu Glu Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val 
145                 150                 155                 160 


Ala His Gly Thr Asn Ser His Glu Met Ala Ile Val Phe Asn Gln Glu 
                165                 170                 175     


Gly Leu Asn Ala Ile Gln Pro Pro Cys Val Val Gln Asn Phe Ile Asn 
            180                 185                 190         


His Asn Ala Val Leu Tyr Lys Val Phe Val Val Gly Glu Ser Tyr Thr 
        195                 200                 205             


Val Val Gln Arg Pro Ser Leu Lys Asn Phe Ser Ala Gly Thr Ser Asp 
    210                 215                 220                 


Arg Glu Ser Ile Phe Phe Asn Ser His Asn Val Ser Lys Pro Glu Ser 
225                 230                 235                 240 


Ser Ser Val Leu Thr Glu Leu Asp Lys Ile Glu Gly Val Phe Glu Arg 
                245                 250                 255     


Pro Ser Asp Glu Val Ile Arg Glu Leu Ser Arg Ala Leu Arg Gln Ala 
            260                 265                 270         


Leu Gly Val Ser Leu Phe Gly Ile Asp Ile Ile Ile Asn Asn Gln Thr 
        275                 280                 285             


Gly Gln His Ala Val Ile Asp Ile Asn Ala Phe Pro Gly Asp Cys Gln 
    290                 295                 300                 


Val Cys Phe Ile Glu Gly Trp Lys Thr Asp 
305                 310                 


<210> 5847
<211> 209
<212> PRT
<213> Homo sapiens

<400> 5847
Met Pro Val Ala Val Met Ala Glu Ser Ala Phe Ser Phe Lys Lys Leu 
1               5                   10                  15      


Leu Asp Gln Cys Glu Asn Gln Glu Leu Glu Ala Pro Gly Gly Ile Ala 
            20                  25                  30          


Thr Pro Pro Val Tyr Gly Gln Leu Leu Ala Leu Tyr Leu Leu His Asn 
        35                  40                  45              


Asp Met Asn Asn Ala Arg Tyr Leu Trp Lys Arg Ile Pro Pro Ala Ile 
    50                  55                  60                  


Lys Ser Ala Asn Ser Glu Leu Gly Gly Ile Trp Ser Val Gly Gln Arg 
65                  70                  75                  80  


Ile Trp Gln Arg Asp Phe Pro Gly Ile Tyr Thr Thr Ile Asn Ala His 
                85                  90                  95      


Gln Trp Ser Glu Thr Val Gln Pro Ile Met Glu Ala Leu Arg Asp Ala 
            100                 105                 110         


Thr Arg Arg Arg Ala Phe Ala Leu Val Ser Gln Ala Tyr Thr Ser Ile 
        115                 120                 125             


Ile Ala Asp Asp Phe Ala Ala Phe Val Gly Leu Pro Val Glu Glu Ala 
    130                 135                 140                 


Val Lys Gly Ile Leu Glu Gln Gly Trp Gln Ala Asp Ser Thr Thr Arg 
145                 150                 155                 160 


Met Val Leu Pro Arg Lys Pro Val Ala Gly Ala Leu Asp Val Ser Phe 
                165                 170                 175     


Asn Lys Phe Ile Pro Leu Ser Glu Pro Ala Pro Val Pro Pro Ile Pro 
            180                 185                 190         


Asn Glu Gln Gln Leu Ala Arg Leu Thr Asp Tyr Val Ala Phe Leu Glu 
        195                 200                 205             


Asn 
    


<210> 5848
<211> 1644
<212> PRT
<213> Homo sapiens

<400> 5848
Met Phe Trp Cys Gly Thr Cys Phe Val Thr Asn Asn Met Lys Gly Ser 
1               5                   10                  15      


Glu Val Ser Leu Glu Lys Lys Lys Lys Ile Lys Met Pro Val Lys Arg 
            20                  25                  30          


Leu Arg Glu Val Val Ser Gln Asn His Gly Asp His Leu Val Leu Leu 
        35                  40                  45              


Lys Asp Glu Leu Pro Cys Val Pro Pro Ala Leu Ser Ala Asn Lys Arg 
    50                  55                  60                  


Leu Pro Val Gly Thr Gly Thr Ser Leu Asn Gly Thr Ser Arg Gly Ser 
65                  70                  75                  80  


Ser Asp Leu Thr Ser Ala Arg Asn Cys Tyr Gln Pro Leu Leu Glu Asn 
                85                  90                  95      


Pro Met Val Ser Glu Ser Asp Phe Ser Lys Asp Val Ala Val Gln Val 
            100                 105                 110         


Leu Pro Leu Asp Lys Ile Glu Glu Asn Asn Lys Gln Lys Ala Asn Asp 
        115                 120                 125             


Ile Phe Ile Ser Gln Tyr Thr Met Gly Gln Lys Asp Ala Leu Arg Thr 
    130                 135                 140                 


Val Leu Lys Gln Asn Val Ser Leu Cys Leu Thr Gly Trp Ser Asp His 
145                 150                 155                 160 


Ser Gly Val Ile Thr Thr His Cys Ser Leu Tyr Leu Leu Arg Leu Met 
                165                 170                 175     


Arg Ser Ser His Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Ala Gln 
            180                 185                 190         


Ser Met Pro Val Phe Lys Glu Val Lys Val His Leu Leu Glu Asp Ala 
        195                 200                 205             


Gly Ile Glu Lys Asp Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser 
    210                 215                 220                 


Gly Ile Asp Ser Ala Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile 
225                 230                 235                 240 


Ala Thr Ala Ala Pro Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys 
                245                 250                 255     


Val Asn Ser Val Thr Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys 
            260                 265                 270         


His Leu Gln Arg Val Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln 
        275                 280                 285             


Glu Lys Leu His Cys His Asp His Glu Lys Gln Met Asn Val Phe Met 
    290                 295                 300                 


Glu Gln His Ile Arg His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp 
305                 310                 315                 320 


Ile Gln Thr His Phe Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln 
                325                 330                 335     


Pro Val Ser Met Pro Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys 
            340                 345                 350         


Pro Glu His Pro Asn Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr 
        355                 360                 365             


Phe Ala Ser Lys Gln Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe 
    370                 375                 380                 


Asp Lys Gln Lys Ser Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala 
385                 390                 395                 400 


Pro Val Pro Val Ser Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu 
                405                 410                 415     


Leu Glu Glu Lys Glu Asn Met Glu Val Ser Cys His Arg Gly Asn Val 
            420                 425                 430         


Arg Leu Leu Glu Gln Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys 
        435                 440                 445             


Ser Glu Ser Ser Asn Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp 
    450                 455                 460                 


Thr Pro Glu Lys Thr Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr 
465                 470                 475                 480 


Thr Lys Val Thr Met Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly 
                485                 490                 495     


Gln Lys Glu Lys Glu Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu 
            500                 505                 510         


Ser Met Leu Lys Leu Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln 
        515                 520                 525             


Thr Thr Asn Thr Thr Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu 
    530                 535                 540                 


Arg Gly Val Gln Asn Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala 
545                 550                 555                 560 


Ile Ile Arg Ala Lys Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala 
                565                 570                 575     


Leu Ser Thr Asn Arg Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr 
            580                 585                 590         


Val Asp Glu Trp Ile Lys Thr Ile Ser Ala Glu Ile Gln Asp Glu Leu 
        595                 600                 605             


Ser Arg Thr Asp Tyr Glu Gln Lys Arg Phe Asp Gln Lys Asn Gln Arg 
    610                 615                 620                 


Thr Lys Lys Gly Gln Asn Met Thr Lys Asp Ile Arg Thr Asn Thr Gln 
625                 630                 635                 640 


Asp Lys Thr Val Asn Lys Ser Val Ile Pro Arg Lys His Ser Gln Lys 
                645                 650                 655     


Gln Ile Glu Glu His Phe Arg Asn Leu Pro Met Arg Gly Met Pro Ala 
            660                 665                 670         


Ser Ser Leu Gln Lys Glu Arg Lys Glu Gly Leu Leu Lys Ala Thr Thr 
        675                 680                 685             


Val Ile Gln Asp Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val 
    690                 695                 700                 


Tyr Gln Gly His Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe 
705                 710                 715                 720 


Asn Ser Pro Ser Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu 
                725                 730                 735     


Arg Val Lys Gly Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe 
            740                 745                 750         


Tyr Ala Thr Lys Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val 
        755                 760                 765             


Pro Val Leu Pro His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg 
    770                 775                 780                 


Glu Met Pro Thr Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met 
785                 790                 795                 800 


Ala Ile Leu Leu Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro 
                805                 810                 815     


Ala Gly Val Ile Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser 
            820                 825                 830         


Ile Pro Pro Ser Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn 
        835                 840                 845             


Ile Ala Ile Val Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu 
    850                 855                 860                 


Thr Val Gln Val Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser 
865                 870                 875                 880 


Ser Ala Asp Val Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Leu 
                885                 890                 895     


Pro Pro Val Gln Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp 
            900                 905                 910         


Glu Glu Glu Val Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp 
        915                 920                 925             


Val Ile Gln Glu Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro 
    930                 935                 940                 


Ile Leu Glu Phe Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn 
945                 950                 955                 960 


Gly Pro Pro Phe Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp 
                965                 970                 975     


Ile Leu Asp Lys Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu 
            980                 985                 990         


Ile Gln Trp Val Glu Gln Glu Ile  Met Ser Arg Ile Ile  Ser Gly Leu 
        995                 1000                 1005             


Phe Pro  Val Gln Gln Gln Ile  Ala Pro Ser Ile Ser  Val Ser Val 
    1010                 1015                 1020             


Ser Glu  Thr Ser Glu Pro Leu  Thr Ser Asp Ile Val  Glu Gly Thr 
    1025                 1030                 1035             


Ser Ser  Gly Ala Leu Gln Leu  Phe Val Asp Ala Gly  Val Pro Val 
    1040                 1045                 1050             


Asn Ser  Asn Val Ile Lys His  Phe Val Asn Glu Ala  Leu Ala Glu 
    1055                 1060                 1065             


Thr Ile  Ala Val Met Leu Gly  Asp Arg Glu Ala Lys  Lys Gln Gly 
    1070                 1075                 1080             


Pro Val  Ala Thr Gly Val Ser  Gly Asp Ala Ser Thr  Asn Glu Thr 
    1085                 1090                 1095             


Tyr Leu  Pro Ala Arg Val Cys  Thr Pro Leu Pro Thr  Pro Gln Pro 
    1100                 1105                 1110             


Thr Pro  Pro Cys Ser Pro Ser  Ser Pro Ala Lys Glu  Cys Val Leu 
    1115                 1120                 1125             


Val Lys  Thr Pro Asp Ser Ser  Pro Cys Asp Ser Asp  His Asp Met 
    1130                 1135                 1140             


Ala Phe  Pro Val Lys Glu Ile  Cys Ala Glu Lys Gly  Asp Asp Met 
    1145                 1150                 1155             


Pro Ala  Ile Met Leu Val Asn  Thr Pro Thr Val Thr  Pro Thr Thr 
    1160                 1165                 1170             


Thr Pro  Pro Pro Ala Ala Ala  Val Phe Thr Pro Thr  Leu Ser Asp 
    1175                 1180                 1185             


Ile Ser  Ile Asp Lys Leu Lys  Val Ser Ser Pro Glu  Leu Pro Lys 
    1190                 1195                 1200             


Pro Trp  Gly Asp Gly Asp Leu  Pro Leu Glu Glu Glu  Asn Pro Asn 
    1205                 1210                 1215             


Ser Pro  Gln Glu Glu Leu His  Pro Arg Ala Ile Val  Met Ser Val 
    1220                 1225                 1230             


Ala Lys  Asp Glu Glu Pro Glu  Ser Met Asp Phe Pro  Ala Gln Pro 
    1235                 1240                 1245             


Pro Pro  Pro Glu Pro Val Pro  Phe Met Pro Phe Pro  Ala Gly Thr 
    1250                 1255                 1260             


Lys Ala  Pro Ser Pro Ser Gln  Met Pro Gly Ser Asp  Ser Ser Thr 
    1265                 1270                 1275             


Leu Glu  Ser Thr Leu Ser Val  Thr Val Thr Glu Thr  Glu Thr Leu 
    1280                 1285                 1290             


Asp Lys  Pro Ile Ser Glu Gly  Glu Ile Leu Phe Ser  Cys Gly Gln 
    1295                 1300                 1305             


Lys Leu  Ala Pro Lys Ile Leu  Glu Asp Ile Gly Leu  Tyr Leu Thr 
    1310                 1315                 1320             


Asn Leu  Asn Asp Ser Leu Ser  Ser Thr Leu His Asp  Ala Val Glu 
    1325                 1330                 1335             


Met Glu  Asp Asp Pro Pro Ser  Glu Gly Gln Val Ile  Arg Met Ser 
    1340                 1345                 1350             


His Lys  Lys Phe His Ala Asp  Ala Ile Leu Ser Phe  Ala Lys Gln 
    1355                 1360                 1365             


Asn Gln  Glu Ser Ala Val Ser  Gln Gln Ala Val Tyr  His Ser Glu 
    1370                 1375                 1380             


Asp Leu  Glu Asn Ser Val Gly  Glu Leu Ser Glu Gly  Gln Arg Pro 
    1385                 1390                 1395             


Gln Leu  Thr Ala Ala Ala Glu  Asn Ile Leu Met Gly  His Ser Leu 
    1400                 1405                 1410             


Tyr Met  Gln Pro Pro Val Thr  Asn Thr Gln Ser Leu  Asp Gln Gln 
    1415                 1420                 1425             


Cys Asp  Pro Lys Pro Leu Ser  Arg Gln Phe Asp Thr  Val Ser Gly 
    1430                 1435                 1440             


Ser Ile  Tyr Glu Asp Ser Cys  Ala Ser His Gly Pro  Met Ser Leu 
    1445                 1450                 1455             


Gly Glu  Leu Glu Leu Glu Pro  Asn Ser Lys Leu Val  Leu Pro Thr 
    1460                 1465                 1470             


Thr Leu  Leu Thr Ala Gln Glu  Asn Asp Val Asn Leu  Pro Val Ala 
    1475                 1480                 1485             


Ala Glu  Asp Phe Ser Gln Tyr  Gln Leu Lys Gln Asn  Gln Asp Val 
    1490                 1495                 1500             


Lys Gln  Val Glu His Lys Pro  Ser Gln Ser Tyr Leu  Arg Val Arg 
    1505                 1510                 1515             


Asn Lys  Ser Asp Ile Ala Pro  Ser Gln Gln Gln Val  Ser Pro Gly 
    1520                 1525                 1530             


Asp Met  Asp Arg Thr Gln Ile  Glu Leu Asn Pro Tyr  Leu Thr Cys 
    1535                 1540                 1545             


Val Phe  Ser Gly Leu Gly Val  His Val Lys Lys Val  Ser Cys Ile 
    1550                 1555                 1560             


Gly Lys  Leu Gly Leu Trp Arg  Phe Val Ile Gln Ile  Ile Ser Ser 
    1565                 1570                 1575             


Pro Arg  Trp Glu Ser Ser Ala  Thr Leu Arg Phe Thr  Asp Ala Pro 
    1580                 1585                 1590             


Cys Gln  Asp Val Ser Asp Ala  Ala Val Ser Glu Pro  Arg Gly Leu 
    1595                 1600                 1605             


Leu Ser  Val Ser Glu Ser Gln  His Asn Ala Gly Gly  His Gly Val 
    1610                 1615                 1620             


Phe Gly  Gly Arg Tyr Leu Leu  Asn Gly Lys Arg Gln  Pro Ala Gln 
    1625                 1630                 1635             


Cys Leu  Cys His Trp Phe 
    1640                 


<210> 5849
<211> 1045
<212> PRT
<213> Homo sapiens

<400> 5849
Met Leu Thr Val Gln Val Lys Thr Ser Ser Ala Ile Glu Leu Pro Asp 
1               5                   10                  15      


Ser Leu Ala Phe Leu Trp Ile Ile Pro Met Trp Tyr Cys Glu Gly Lys 
            20                  25                  30          


Glu Leu Glu Asn Ser Pro Asp Ile His Ile Val Gln Ala Gly Asn Leu 
        35                  40                  45              


His Ser Leu Thr Ile Ala Glu Ala Phe Glu Glu Asp Thr Gly Arg Tyr 
    50                  55                  60                  


Ser Cys Phe Ala Ser Asn Ile Tyr Gly Thr Asp Ser Thr Ser Ala Glu 
65                  70                  75                  80  


Ile Tyr Ile Glu Gly Val Ser Ser Ser Asp Ser Glu Gly Asp Pro Asn 
                85                  90                  95      


Lys Glu Glu Met Asn Arg Ile Gln Lys Pro Asn Glu Val Ser Ser Pro 
            100                 105                 110         


Pro Thr Thr Ser Ala Val Ile Pro Pro Ala Val Pro Gln Ala Gln His 
        115                 120                 125             


Leu Val Ala Gln Pro Arg Val Ala Thr Ile Gln Gln Cys Gln Ser Pro 
    130                 135                 140                 


Thr Asn Tyr Leu Gln Gly Leu Asp Gly Lys Pro Ile Ile Ala Ala Pro 
145                 150                 155                 160 


Val Phe Thr Lys Met Leu Gln Asn Leu Ser Ala Ser Glu Gly Gln Leu 
                165                 170                 175     


Val Val Phe Glu Cys Arg Val Lys Gly Ala Pro Ser Pro Lys Val Glu 
            180                 185                 190         


Trp Tyr Arg Glu Gly Thr Leu Ile Glu Asp Ser Pro Asp Phe Arg Ile 
        195                 200                 205             


Leu Gln Lys Lys Pro Arg Ser Met Ala Glu Pro Glu Glu Ile Cys Thr 
    210                 215                 220                 


Leu Val Ile Ala Glu Val Phe Ala Glu Asp Ser Gly Cys Phe Thr Cys 
225                 230                 235                 240 


Thr Ala Ser Asn Lys Tyr Gly Thr Val Ser Ser Ile Ala Gln Leu His 
                245                 250                 255     


Val Arg Gly Asn Glu Asp Leu Ser Asn Asn Gly Ser Leu His Ser Ala 
            260                 265                 270         


Asn Ser Thr Thr Asn Leu Ala Ala Ile Glu Pro Gln Pro Ser Pro Pro 
        275                 280                 285             


His Ser Glu Pro Pro Ser Val Glu Gln Pro Pro Lys Pro Lys Leu Glu 
    290                 295                 300                 


Gly Val Leu Val Asn His Asn Glu Pro Arg Ser Ser Ser Arg Ile Gly 
305                 310                 315                 320 


Leu Arg Val His Phe Asn Leu Pro Glu Asp Asp Lys Gly Ser Glu Ala 
                325                 330                 335     


Ser Ser Glu Ala Gly Val Val Thr Thr Arg Gln Thr Arg Pro Asp Ser 
            340                 345                 350         


Phe Gln Glu Arg Phe Asn Gly Gln Ala Thr Lys Thr Pro Glu Pro Ser 
        355                 360                 365             


Ser Pro Val Lys Glu Pro Pro Pro Val Leu Ala Lys Pro Lys Leu Asp 
    370                 375                 380                 


Ser Thr Gln Leu Gln Gln Leu His Asn Gln Val Leu Leu Glu Gln His 
385                 390                 395                 400 


Gln Leu Gln Asn Pro Pro Pro Ser Ser Pro Lys Glu Phe Pro Phe Ser 
                405                 410                 415     


Met Thr Val Leu Asn Ser Asn Ala Pro Pro Ala Val Thr Thr Ser Ser 
            420                 425                 430         


Lys Gln Val Lys Ala Pro Ser Ser Gln Thr Phe Ser Leu Ala Arg Pro 
        435                 440                 445             


Lys Tyr Phe Phe Pro Ser Thr Asn Thr Thr Ala Ala Thr Val Ala Pro 
    450                 455                 460                 


Ser Ser Ser Pro Val Phe Thr Leu Ser Ser Thr Pro Gln Thr Ile Gln 
465                 470                 475                 480 


Arg Thr Val Ser Lys Glu Ser Leu Leu Val Ser His Pro Ser Val Gln 
                485                 490                 495     


Thr Lys Ser Pro Gly Gly Leu Ser Ile Gln Asn Glu Pro Leu Pro Pro 
            500                 505                 510         


Gly Pro Thr Glu Pro Thr Pro Pro Pro Phe Thr Phe Ser Ile Pro Ser 
        515                 520                 525             


Gly Asn Gln Phe Gln Pro Arg Cys Val Ser Pro Ile Pro Val Ser Pro 
    530                 535                 540                 


Thr Ser Arg Ile Gln Asn Pro Val Ala Phe Leu Ser Ser Val Leu Pro 
545                 550                 555                 560 


Ser Leu Pro Ala Ile Pro Pro Thr Asn Ala Met Gly Leu Pro Arg Ser 
                565                 570                 575     


Ala Pro Ser Met Pro Ser Gln Gly Leu Ala Lys Lys Asn Thr Lys Ser 
            580                 585                 590         


Pro Gln Pro Val Asn Asp Asp Asn Ile Arg Glu Thr Lys Asn Ala Val 
        595                 600                 605             


Ile Arg Asp Leu Gly Lys Lys Ile Thr Phe Ser Asp Val Arg Pro Asn 
    610                 615                 620                 


Gln Gln Glu Tyr Lys Ile Ser Ser Phe Glu Gln Arg Leu Met Asn Glu 
625                 630                 635                 640 


Ile Glu Phe Arg Leu Glu Arg Thr Pro Val Asp Glu Ser Asp Asp Glu 
                645                 650                 655     


Ile Gln His Asp Glu Ile Pro Thr Gly Lys Cys Ile Ala Pro Ile Phe 
            660                 665                 670         


Asp Lys Arg Leu Lys His Phe Arg Val Thr Glu Gly Ser Pro Val Thr 
        675                 680                 685             


Phe Thr Cys Lys Ile Val Gly Ile Pro Val Pro Lys Val Tyr Trp Phe 
    690                 695                 700                 


Lys Asp Gly Lys Gln Ile Ser Lys Arg Asn Glu His Cys Lys Met Arg 
705                 710                 715                 720 


Arg Glu Gly Asp Gly Thr Cys Ser Leu His Ile Glu Ser Thr Thr Ser 
                725                 730                 735     


Asp Asp Asp Gly Asn Tyr Thr Ile Met Ala Ala Asn Pro Gln Gly Arg 
            740                 745                 750         


Ile Ser Cys Ser Gly His Leu Met Val Gln Ser Leu Pro Ile Arg Ser 
        755                 760                 765             


Arg Leu Thr Ser Ala Gly Gln Ser His Arg Gly Arg Ser Arg Val Gln 
    770                 775                 780                 


Glu Arg Asp Lys Glu Pro Leu Gln Glu Arg Phe Phe Arg Pro His Phe 
785                 790                 795                 800 


Leu Gln Ala Pro Gly Asp Met Val Ala His Glu Gly Arg Leu Cys Arg 
                805                 810                 815     


Leu Asp Cys Lys Val Ser Gly Leu Pro Pro Pro Glu Leu Thr Trp Leu 
            820                 825                 830         


Leu Asn Gly Gln Pro Val Leu Pro Asp Ala Ser His Lys Met Leu Val 
        835                 840                 845             


Arg Glu Thr Gly Val His Ser Leu Leu Ile Asp Pro Leu Thr Gln Arg 
    850                 855                 860                 


Asp Ala Gly Thr Tyr Lys Cys Ile Ala Thr Asn Lys Thr Gly Gln Asn 
865                 870                 875                 880 


Ser Phe Ser Leu Glu Leu Ser Val Val Ala Lys Glu Val Lys Lys Ala 
                885                 890                 895     


Pro Val Ile Leu Glu Lys Leu Gln Asn Cys Gly Val Pro Glu Gly His 
            900                 905                 910         


Pro Val Arg Leu Glu Cys Arg Val Ile Gly Met Pro Pro Pro Val Phe 
        915                 920                 925             


Tyr Trp Lys Lys Asp Asn Glu Thr Ile Pro Cys Thr Arg Glu Arg Ile 
    930                 935                 940                 


Ser Met His Gln Asp Thr Thr Gly Tyr Ala Cys Leu Leu Ile Gln Pro 
945                 950                 955                 960 


Ala Lys Lys Ser Asp Ala Gly Trp Tyr Thr Leu Ser Ala Lys Asn Glu 
                965                 970                 975     


Ala Gly Ile Val Ser Cys Thr Ala Arg Leu Asp Ile Tyr Ala Gln Trp 
            980                 985                 990         


His His Gln Ile Pro Pro Pro Met  Ser Val Arg Pro Ser  Gly Ser Arg 
        995                 1000                 1005             


Tyr Gly  Ser Leu Thr Ser Lys  Gly Leu Asp Ile Phe  Ser Ala Phe 
    1010                 1015                 1020             


Ser Ser  Met Glu Ser Thr Met  Val Tyr Ser Cys Ser  Ser Arg Ser 
    1025                 1030                 1035             


Val Val  Glu Ser Asp Glu Leu  
    1040                 1045 


<210> 5850
<211> 316
<212> PRT
<213> Homo sapiens

<400> 5850
Met Thr Pro Ser Glu Gly Ala Arg Ala Gly Thr Gly Arg Glu Leu Glu 
1               5                   10                  15      


Met Leu Asp Ser Leu Leu Ala Leu Gly Gly Leu Val Leu Leu Arg Asp 
            20                  25                  30          


Ser Val Glu Trp Glu Gly Arg Ser Leu Leu Lys Ala Leu Val Lys Lys 
        35                  40                  45              


Ser Ala Leu Cys Gly Glu Gln Val His Ile Leu Gly Cys Glu Val Ser 
    50                  55                  60                  


Glu Glu Glu Phe Arg Glu Gly Phe Asp Ser Asp Ile Asn Asn Arg Leu 
65                  70                  75                  80  


Val Tyr His Asp Phe Phe Arg Asp Pro Leu Asn Trp Ser Lys Thr Glu 
                85                  90                  95      


Glu Ala Phe Pro Gly Gly Pro Leu Gly Ala Leu Arg Ala Met Cys Lys 
            100                 105                 110         


Arg Thr Asp Pro Val Pro Val Thr Ile Ala Leu Asp Ser Leu Ser Trp 
        115                 120                 125             


Leu Leu Leu Arg Leu Pro Cys Thr Thr Leu Cys Gln Val Leu His Ala 
    130                 135                 140                 


Val Ser His Gln Asp Ser Cys Pro Gly Asp Ser Ser Ser Val Gly Lys 
145                 150                 155                 160 


Val Ser Val Leu Gly Leu Leu His Glu Glu Leu His Gly Pro Gly Pro 
                165                 170                 175     


Val Gly Ala Leu Ser Ser Leu Ala Gln Thr Glu Val Thr Leu Gly Gly 
            180                 185                 190         


Thr Met Gly Gln Ala Ser Ala His Ile Leu Cys Arg Arg Pro Arg Gln 
        195                 200                 205             


Arg Pro Thr Asp Gln Thr Gln Trp Phe Ser Ile Leu Pro Asp Phe Ser 
    210                 215                 220                 


Leu Asp Leu Gln Glu Gly Pro Ser Val Glu Ser Gln Pro Tyr Ser Asp 
225                 230                 235                 240 


Pro His Ile Pro Pro Val Asp Pro Thr Thr His Leu Thr Phe Asn Leu 
                245                 250                 255     


His Leu Ser Lys Lys Glu Arg Glu Ala Arg Asp Ser Leu Ile Leu Pro 
            260                 265                 270         


Phe Gln Phe Ser Ser Glu Lys Gln Gln Ala Leu Leu Arg Pro Arg Pro 
        275                 280                 285             


Gly Gln Ala Thr Ser His Ile Phe Tyr Glu Pro Asp Ala Tyr Asp Asp 
    290                 295                 300                 


Leu Asp Gln Glu Asp Pro Asp Asp Asp Leu Asp Ile 
305                 310                 315     


<210> 5851
<211> 490
<212> PRT
<213> Homo sapiens

<400> 5851
Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu 
            20                  25                  30          


Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu 
        195                 200                 205             


Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly 
225                 230                 235                 240 


Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu 
                245                 250                 255     


Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser 
            260                 265                 270         


Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu 
        275                 280                 285             


Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala 
    290                 295                 300                 


Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Val Ala 
                325                 330                 335     


Gln Met Leu Ser Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr 
            340                 345                 350         


Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala 
        355                 360                 365             


Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr 
    370                 375                 380                 


Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu 
385                 390                 395                 400 


Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe 
                405                 410                 415     


Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile 
            420                 425                 430         


Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe 
        435                 440                 445             


Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln 
    450                 455                 460                 


Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu 
465                 470                 475                 480 


Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
                485                 490 


<210> 5852
<211> 475
<212> PRT
<213> Homo sapiens

<400> 5852
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Thr Met Arg Val Asn Asp Leu Val Gly Thr 
225                 230                 235                 240 


Ser Met Thr Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Thr Asn Thr Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Ser Leu Glu Ser Val Ser Ala Thr Cys Lys Gln 
305                 310                 315                 320 


Leu Ser Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu 
                325                 330                 335     


Ala His Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln 
            340                 345                 350         


Ile Leu Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys 
        355                 360                 365             


Met Glu Ile Ser His Leu Thr Gln Glu Leu His Gln Arg Asp Ile Thr 
    370                 375                 380                 


Ile Ala Ser Thr Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg 
385                 390                 395                 400 


Ala Glu Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile 
                405                 410                 415     


Leu Asp Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu 
            420                 425                 430         


Met Val Met Lys Leu Glu Leu Gly Leu His Glu Arg Trp Gly Phe Thr 
        435                 440                 445             


Met Leu Ser Ser Leu Val Leu Asn Phe Gly Ile Gln Ala Ile Arg Gln 
    450                 455                 460                 


Pro Gln Arg Pro Lys Val Leu Glu Leu Gln Val 
465                 470                 475 


<210> 5853
<211> 779
<212> PRT
<213> Homo sapiens

<400> 5853
Met Arg Ile Glu Glu Arg Lys Ser Gln His Leu Thr Gly Leu Thr Asp 
1               5                   10                  15      


Glu Lys Val Lys Ala Tyr Leu Ser Leu His Pro Gln Val Leu Asp Glu 
            20                  25                  30          


Phe Val Ser Glu Ser Val Ser Ala Glu Thr Val Glu Lys Trp Leu Lys 
        35                  40                  45              


Arg Lys Asn Asn Lys Ser Glu Asp Glu Ser Ala Pro Lys Glu Val Ser 
    50                  55                  60                  


Arg Tyr Gln Asp Thr Asn Met Gln Gly Val Val Tyr Glu Leu Asn Ser 
65                  70                  75                  80  


Tyr Ile Glu Gln Arg Leu Asp Thr Gly Gly Asp Asn Gln Leu Leu Leu 
                85                  90                  95      


Tyr Glu Leu Ser Ser Ile Ile Lys Ile Ala Thr Lys Ala Asp Gly Phe 
            100                 105                 110         


Ala Leu Tyr Phe Leu Gly Glu Cys Asn Asn Ser Leu Cys Ile Phe Thr 
        115                 120                 125             


Pro Pro Gly Ile Lys Glu Gly Lys Pro Arg Leu Ile Pro Ala Gly Pro 
    130                 135                 140                 


Ile Thr Gln Gly Thr Thr Val Ser Ala Tyr Val Ala Lys Ser Arg Lys 
145                 150                 155                 160 


Thr Leu Leu Val Glu Asp Ile Leu Gly Asp Glu Arg Phe Pro Arg Gly 
                165                 170                 175     


Thr Gly Leu Glu Ser Gly Thr Arg Ile Gln Ser Val Leu Cys Leu Pro 
            180                 185                 190         


Ile Val Thr Ala Ile Gly Asp Leu Ile Gly Ile Leu Glu Leu Tyr Arg 
        195                 200                 205             


His Trp Gly Lys Glu Ala Phe Cys Leu Ser His Gln Glu Val Ala Thr 
    210                 215                 220                 


Ala Asn Leu Ala Trp Ala Ser Val Ala Ile His Gln Val Gln Val Cys 
225                 230                 235                 240 


Arg Gly Leu Ala Lys Gln Thr Glu Leu Asn Asp Phe Leu Leu Asp Val 
                245                 250                 255     


Ser Lys Thr Tyr Phe Asp Asn Ile Val Ala Ile Asp Ser Leu Leu Glu 
            260                 265                 270         


His Ile Met Ile Tyr Ala Lys Asn Leu Val Asn Ala Asp Arg Cys Ala 
        275                 280                 285             


Leu Phe Gln Val Asp His Lys Asn Lys Glu Leu Tyr Ser Asp Leu Phe 
    290                 295                 300                 


Asp Ile Gly Glu Glu Lys Glu Gly Lys Pro Val Phe Lys Lys Thr Lys 
305                 310                 315                 320 


Glu Ile Arg Phe Ser Ile Glu Lys Gly Ile Ala Gly Gln Val Ala Arg 
                325                 330                 335     


Thr Gly Glu Val Leu Asn Ile Pro Asp Ala Tyr Ala Asp Pro Arg Phe 
            340                 345                 350         


Asn Arg Glu Val Asp Leu Tyr Thr Gly Tyr Thr Thr Arg Asn Ile Leu 
        355                 360                 365             


Cys Met Pro Ile Val Ser Arg Gly Ser Val Ile Gly Val Val Gln Met 
    370                 375                 380                 


Val Asn Lys Ile Ser Gly Ser Ala Phe Ser Lys Thr Asp Glu Asn Asn 
385                 390                 395                 400 


Phe Lys Met Phe Ala Val Phe Cys Ala Leu Ala Leu His Cys Ala Asn 
                405                 410                 415     


Met Tyr His Arg Ile Arg His Ser Glu Cys Ile Tyr Arg Val Thr Met 
            420                 425                 430         


Glu Lys Leu Ser Tyr His Ser Ile Cys Thr Ser Glu Glu Trp Gln Gly 
        435                 440                 445             


Leu Met Gln Phe Thr Leu Pro Val Arg Leu Cys Lys Glu Ile Glu Leu 
    450                 455                 460                 


Phe His Phe Asp Ile Gly Pro Phe Glu Asn Met Trp Pro Gly Ile Phe 
465                 470                 475                 480 


Val Tyr Met Val His Arg Ser Cys Gly Thr Ser Cys Phe Glu Leu Glu 
                485                 490                 495     


Lys Leu Cys Arg Phe Ile Met Ser Val Lys Lys Asn Tyr Arg Arg Val 
            500                 505                 510         


Pro Tyr His Asn Trp Lys His Ala Val Thr Val Ala His Cys Met Tyr 
        515                 520                 525             


Ala Ile Leu Gln Asn Asn His Thr Leu Phe Thr Asp Leu Glu Arg Lys 
    530                 535                 540                 


Gly Leu Leu Ile Ala Cys Leu Cys His Asp Leu Asp His Arg Gly Phe 
545                 550                 555                 560 


Ser Asn Ser Tyr Leu Gln Lys Phe Asp His Pro Leu Ala Ala Leu Tyr 
                565                 570                 575     


Ser Thr Ser Thr Met Glu Gln His His Phe Ser Gln Thr Val Ser Ile 
            580                 585                 590         


Leu Gln Leu Glu Gly His Asn Ile Phe Ser Thr Leu Ser Ser Ser Glu 
        595                 600                 605             


Tyr Glu Gln Val Leu Glu Ile Ile Arg Lys Ala Ile Ile Ala Thr Asp 
    610                 615                 620                 


Leu Ala Leu Tyr Phe Gly Asn Arg Lys Gln Leu Glu Glu Met Tyr Gln 
625                 630                 635                 640 


Thr Gly Ser Leu Asn Leu Asn Asn Gln Ser His Arg Asp Arg Val Ile 
                645                 650                 655     


Gly Leu Met Met Thr Ala Cys Asp Leu Cys Ser Val Thr Lys Leu Trp 
            660                 665                 670         


Pro Val Thr Lys Leu Thr Ala Asn Asp Ile Tyr Ala Glu Phe Trp Ala 
        675                 680                 685             


Glu Gly Asp Glu Met Lys Lys Leu Gly Ile Gln Pro Ile Pro Met Met 
    690                 695                 700                 


Asp Arg Asp Lys Lys Asp Glu Val Pro Gln Gly Gln Leu Gly Phe Tyr 
705                 710                 715                 720 


Asn Ala Val Ala Ile Pro Cys Tyr Thr Thr Leu Thr Gln Ile Leu Pro 
                725                 730                 735     


Pro Thr Glu Pro Leu Leu Lys Ala Cys Arg Asp Asn Leu Ser Gln Trp 
            740                 745                 750         


Glu Lys Val Ile Arg Gly Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro 
        755                 760                 765             


Ser Val Ala Gln Lys Ala Ala Ala Ser Glu Asp 
    770                 775                 


<210> 5854
<211> 703
<212> PRT
<213> Homo sapiens

<400> 5854
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe 
                85                  90                  95      


Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile 
            100                 105                 110         


Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu 
        115                 120                 125             


Asn Lys Phe Leu Leu Leu Thr Phe Ala Asp Leu Lys Lys Tyr His Phe 
    130                 135                 140                 


Tyr Tyr Trp Phe Cys Tyr Pro Ala Leu Cys Leu Pro Glu Ser Leu Pro 
145                 150                 155                 160 


Leu Ile Gln Gly Pro Val Gly Leu Asp Gln Arg Phe Ser Leu Lys Gln 
                165                 170                 175     


Ile Glu Ala Leu Glu Cys Ala Tyr Asp Asn Leu Cys Gln Thr Glu Gly 
            180                 185                 190         


Val Thr Ala Leu Pro Tyr Phe Leu Ile Lys Tyr Asp Glu Asn Met Val 
        195                 200                 205             


Leu Val Ser Leu Leu Lys His Tyr Ser Asp Phe Phe Gln Gly Gln Arg 
    210                 215                 220                 


Thr Lys Ile Thr Ile Gly Val Tyr Asp Pro Cys Asn Leu Ala Gln Tyr 
225                 230                 235                 240 


Pro Gly Trp Pro Leu Arg Asn Phe Leu Val Leu Ala Ala His Arg Trp 
                245                 250                 255     


Ser Ser Ser Phe Gln Ser Val Glu Val Val Cys Phe Arg Asp Arg Thr 
            260                 265                 270         


Met Gln Gly Ala Arg Asp Val Ala His Ser Ile Ile Phe Glu Val Lys 
        275                 280                 285             


Leu Pro Glu Met Ala Phe Ser Pro Asp Cys Pro Lys Ala Val Gly Trp 
    290                 295                 300                 


Glu Lys Asn Gln Lys Gly Gly Met Gly Pro Arg Met Val Asn Leu Ser 
305                 310                 315                 320 


Glu Cys Met Asp Pro Lys Arg Leu Ala Glu Ser Ser Val Asp Leu Asn 
                325                 330                 335     


Leu Lys Leu Met Cys Trp Arg Leu Val Pro Thr Leu Asp Leu Asp Lys 
            340                 345                 350         


Val Val Ser Val Lys Cys Leu Leu Leu Gly Ala Gly Thr Leu Gly Cys 
        355                 360                 365             


Asn Val Ala Arg Thr Leu Met Gly Trp Gly Val Arg His Ile Thr Phe 
    370                 375                 380                 


Val Asp Asn Ala Lys Ile Ser Tyr Ser Asn Pro Val Arg Gln Pro Leu 
385                 390                 395                 400 


Tyr Glu Phe Glu Asp Cys Leu Gly Gly Gly Lys Pro Lys Ala Leu Ala 
                405                 410                 415     


Ala Ala Asp Arg Leu Gln Lys Ile Phe Pro Gly Val Asn Ala Arg Gly 
            420                 425                 430         


Phe Asn Met Ser Ile Pro Met Pro Gly His Pro Val Asn Phe Ser Ser 
        435                 440                 445             


Val Thr Leu Glu Gln Ala Arg Arg Asp Val Glu Gln Leu Glu Gln Leu 
    450                 455                 460                 


Ile Glu Ser His Asp Val Val Phe Leu Leu Met Asp Thr Arg Glu Ser 
465                 470                 475                 480 


Arg Trp Leu Pro Ala Val Ile Ala Ala Ser Lys Arg Lys Leu Val Ile 
                485                 490                 495     


Asn Ala Ala Leu Gly Phe Asp Thr Phe Val Val Met Arg His Gly Leu 
            500                 505                 510         


Lys Lys Pro Lys Gln Gln Gly Ala Gly Asp Leu Cys Pro Asn His Pro 
        515                 520                 525             


Val Ala Ser Ala Asp Leu Leu Gly Ser Ser Leu Phe Ala Asn Ile Pro 
    530                 535                 540                 


Gly Tyr Lys Leu Gly Cys Tyr Phe Cys Asn Asp Val Val Ala Pro Gly 
545                 550                 555                 560 


Asp Ser Thr Arg Asp Arg Thr Leu Asp Gln Gln Cys Thr Val Ser Arg 
                565                 570                 575     


Pro Gly Leu Ala Val Ile Ala Gly Ala Leu Ala Val Glu Leu Met Val 
            580                 585                 590         


Ser Val Leu Gln His Pro Glu Gly Gly Tyr Ala Ile Ala Ser Ser Ser 
        595                 600                 605             


Asp Asp Arg Met Asn Glu Pro Pro Thr Ser Leu Gly Leu Val Pro His 
    610                 615                 620                 


Gln Ile Arg Gly Phe Leu Ser Arg Phe Asp Asn Val Leu Pro Val Ser 
625                 630                 635                 640 


Leu Ala Phe Asp Lys Cys Thr Ala Cys Ser Ser Lys Val Leu Asp Gln 
                645                 650                 655     


Tyr Glu Arg Glu Gly Phe Asn Phe Leu Ala Lys Val Phe Asn Ser Ser 
            660                 665                 670         


His Ser Phe Leu Glu Asp Leu Thr Gly Leu Thr Leu Leu His Gln Glu 
        675                 680                 685             


Thr Gln Ala Ala Glu Ile Trp Asp Met Ser Asp Asp Glu Thr Ile 
    690                 695                 700             


<210> 5855
<211> 1081
<212> PRT
<213> Homo sapiens

<400> 5855
Met Glu Ser Ala Gly Leu Glu Gln Leu Leu Arg Glu Leu Leu Leu Pro 
1               5                   10                  15      


Asp Thr Glu Arg Ile Arg Arg Ala Thr Glu Gln Leu Gln Ile Val Leu 
            20                  25                  30          


Arg Ala Pro Ala Ala Leu Pro Ala Leu Cys Asp Leu Leu Ala Ser Ala 
        35                  40                  45              


Ala Asp Pro Gln Ile Arg Gln Phe Ala Ala Val Leu Thr Arg Arg Arg 
    50                  55                  60                  


Leu Asn Thr Arg Trp Arg Arg Leu Ala Ala Glu Gln Arg Glu Ser Leu 
65                  70                  75                  80  


Lys Ser Leu Ile Leu Thr Ala Leu Gln Arg Glu Thr Glu His Cys Val 
                85                  90                  95      


Ser Leu Ser Leu Ala Gln Leu Ser Ala Thr Ile Phe Arg Lys Glu Gly 
            100                 105                 110         


Leu Glu Ala Trp Pro Gln Leu Leu Gln Leu Leu Gln His Ser Thr His 
        115                 120                 125             


Ser Pro His Ser Pro Glu Arg Glu Met Gly Leu Leu Leu Leu Ser Val 
    130                 135                 140                 


Val Val Thr Ser Arg Pro Glu Ala Phe Gln Pro His His Arg Glu Leu 
145                 150                 155                 160 


Leu Arg Leu Leu Asn Glu Thr Leu Gly Glu Val Gly Ser Pro Gly Leu 
                165                 170                 175     


Leu Phe Tyr Ser Leu Arg Thr Leu Thr Thr Met Ala Pro Tyr Leu Ser 
            180                 185                 190         


Thr Glu Asp Val Pro Leu Ala Arg Met Leu Val Pro Lys Leu Ile Met 
        195                 200                 205             


Ala Met Gln Thr Leu Ile Pro Ile Asp Glu Ala Lys Ala Cys Glu Ala 
    210                 215                 220                 


Leu Glu Ala Leu Asp Glu Leu Leu Glu Ser Glu Val Pro Val Ile Thr 
225                 230                 235                 240 


Pro Tyr Leu Ser Glu Val Leu Thr Phe Cys Leu Glu Val Ala Arg Asn 
                245                 250                 255     


Val Ala Leu Gly Asn Ala Ile Arg Ile Arg Ile Leu Cys Cys Leu Thr 
            260                 265                 270         


Phe Leu Val Lys Val Lys Ser Lys Ala Leu Leu Lys Asn Arg Leu Leu 
        275                 280                 285             


Pro Pro Leu Leu His Thr Leu Phe Pro Ile Val Ala Ala Glu Pro Pro 
    290                 295                 300                 


Pro Gly Gln Leu Asp Pro Glu Asp Gln Asp Ser Glu Glu Glu Glu Leu 
305                 310                 315                 320 


Glu Ile Glu Leu Met Gly Glu Thr Pro Lys His Phe Ala Val Gln Val 
                325                 330                 335     


Val Asp Met Leu Ala Leu His Leu Pro Pro Glu Lys Leu Cys Pro Gln 
            340                 345                 350         


Leu Met Pro Met Leu Glu Glu Ala Leu Arg Ser Glu Ser Pro Tyr Gln 
        355                 360                 365             


Arg Lys Ala Gly Leu Leu Val Leu Ala Val Leu Ser Asp Gly Ala Gly 
    370                 375                 380                 


Asp His Ile Arg Gln Arg Leu Leu Pro Pro Leu Leu Gln Ile Val Cys 
385                 390                 395                 400 


Lys Gly Leu Glu Asp Pro Ser Gln Val Val Arg Asn Ala Ala Leu Phe 
                405                 410                 415     


Ala Leu Gly Gln Phe Ser Glu Asn Leu Gln Pro His Ile Ser Ser Tyr 
            420                 425                 430         


Ser Arg Glu Val Met Pro Leu Leu Leu Ala Tyr Leu Lys Ser Val Pro 
        435                 440                 445             


Leu Gly His Thr His His Leu Ala Lys Ala Cys Tyr Ala Leu Glu Asn 
    450                 455                 460                 


Phe Val Glu Asn Leu Gly Pro Lys Val Gln Pro Tyr Leu Pro Glu Leu 
465                 470                 475                 480 


Met Glu Cys Met Leu Gln Leu Leu Arg Asn Pro Ser Ser Pro Arg Ala 
                485                 490                 495     


Lys Glu Leu Ala Val Ser Ala Leu Gly Ala Ile Ala Thr Ala Ala Gln 
            500                 505                 510         


Ala Ser Leu Leu Pro Tyr Phe Pro Ala Ile Met Glu His Leu Arg Glu 
        515                 520                 525             


Phe Leu Leu Thr Gly Arg Glu Asp Leu Gln Pro Val Gln Ile Gln Ser 
    530                 535                 540                 


Leu Glu Thr Leu Gly Val Leu Ala Arg Ala Val Gly Glu Pro Met Arg 
545                 550                 555                 560 


Pro Leu Ala Glu Glu Cys Cys Gln Leu Gly Leu Gly Leu Cys Asp Gln 
                565                 570                 575     


Val Asp Asp Pro Asp Leu Arg Arg Cys Thr Tyr Ser Leu Phe Ala Ala 
            580                 585                 590         


Leu Ser Gly Leu Met Gly Glu Gly Leu Ala Pro His Leu Glu Gln Ile 
        595                 600                 605             


Thr Thr Leu Met Leu Leu Ser Leu Arg Ser Thr Glu Gly Ile Val Pro 
    610                 615                 620                 


Gln Tyr Asp Gly Ser Ser Ser Phe Leu Leu Phe Asp Asp Glu Ser Asp 
625                 630                 635                 640 


Gly Glu Glu Glu Glu Glu Leu Met Asp Glu Asp Val Glu Glu Glu Asp 
                645                 650                 655     


Asp Ser Glu Ile Ser Gly Tyr Ser Val Glu Asn Ala Phe Phe Asp Glu 
            660                 665                 670         


Lys Glu Asp Thr Cys Ala Ala Val Gly Glu Ile Ser Val Asn Thr Ser 
        675                 680                 685             


Val Ala Phe Leu Pro Tyr Met Glu Ser Val Phe Glu Glu Val Phe Lys 
    690                 695                 700                 


Leu Leu Glu Cys Pro His Leu Asn Val Arg Lys Ala Ala His Glu Ala 
705                 710                 715                 720 


Leu Gly Gln Phe Cys Cys Ala Leu His Lys Ala Cys Gln Ser Cys Pro 
                725                 730                 735     


Ser Glu Pro Asn Thr Ala Ala Leu Gln Ala Ala Leu Ala Arg Val Val 
            740                 745                 750         


Pro Ser Tyr Met Gln Ala Val Asn Arg Glu Arg Glu Arg Gln Val Val 
        755                 760                 765             


Met Ala Val Leu Glu Ala Leu Thr Gly Val Leu Arg Ser Cys Gly Thr 
    770                 775                 780                 


Leu Thr Leu Lys Pro Pro Gly Arg Leu Ala Glu Leu Cys Gly Val Leu 
785                 790                 795                 800 


Lys Ala Val Leu Gln Arg Lys Thr Ala Cys Gln Asp Thr Asp Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Asp Asp Asp Gln Ala Glu Tyr Asp Ala Met Leu Leu 
            820                 825                 830         


Glu His Ala Gly Glu Ala Ile Pro Ala Leu Ala Ala Ala Ala Gly Gly 
        835                 840                 845             


Asp Ser Phe Ala Pro Phe Phe Ala Gly Phe Leu Pro Leu Leu Val Cys 
    850                 855                 860                 


Lys Thr Lys Gln Gly Cys Thr Val Ala Glu Lys Ser Phe Ala Val Gly 
865                 870                 875                 880 


Thr Leu Ala Glu Thr Ile Gln Gly Leu Gly Ala Ala Ser Ala Gln Phe 
                885                 890                 895     


Val Ser Arg Leu Leu Pro Val Leu Leu Ser Thr Ala Gln Glu Ala Asp 
            900                 905                 910         


Pro Glu Val Arg Ser Asn Ala Ile Phe Gly Met Gly Val Leu Ala Glu 
        915                 920                 925             


His Gly Gly His Pro Ala Gln Glu His Phe Pro Lys Leu Leu Gly Leu 
    930                 935                 940                 


Leu Phe Pro Leu Leu Ala Arg Glu Arg His Asp Arg Val Arg Asp Asn 
945                 950                 955                 960 


Ile Cys Gly Ala Leu Ala Arg Leu Leu Met Ala Ser Pro Thr Arg Lys 
                965                 970                 975     


Pro Glu Pro Gln Val Leu Ala Ala Leu Leu His Ala Leu Pro Leu Lys 
            980                 985                 990         


Glu Asp Leu Glu Glu Trp Val Thr  Ile Gly Arg Leu Phe  Ser Phe Leu 
        995                 1000                 1005             


Tyr Gln  Ser Ser Pro Asp Gln  Val Ile Asp Val Ala  Pro Glu Leu 
    1010                 1015                 1020             


Leu Arg  Ile Cys Ser Leu Ile  Leu Ala Asp Asn Lys  Ile Pro Pro 
    1025                 1030                 1035             


Asp Thr  Lys Ala Ala Leu Leu  Leu Leu Leu Thr Phe  Leu Ala Lys 
    1040                 1045                 1050             


Gln His  Thr Asp Ser Phe Gln  Ala Ala Leu Gly Ser  Leu Pro Val 
    1055                 1060                 1065             


Asp Lys  Ala Gln Glu Leu Gln  Ala Val Leu Gly Leu  Ser 
    1070                 1075                 1080     


<210> 5856
<211> 2407
<212> PRT
<213> Homo sapiens

<400> 5856
Met Val Gly Glu Arg His Ala Gly Asp Leu Met Val Pro Leu Gly Pro 
1               5                   10                  15      


Arg Leu Gln Ala Tyr Pro Glu Glu Leu Ile Arg Gln Arg Pro Gly His 
            20                  25                  30          


Asp Gly His Pro Glu Tyr Leu Ile Arg Trp Ser Val Leu Lys Cys Gly 
        35                  40                  45              


Glu Val Gly Lys Val Gly Val Glu Glu Gly Lys Ala Glu His Ile Leu 
    50                  55                  60                  


Met Trp Leu Ser Ala Pro Glu Val Tyr Ala Asn Cys Pro Gly Leu Leu 
65                  70                  75                  80  


Gly Glu Arg Ala Leu Ser Lys Gly Leu Gln His Glu Pro Ala Gly Val 
                85                  90                  95      


Ser Gly Ser Phe Pro Arg Asp Pro Gly Gly Leu Asp Glu Val Ala Met 
            100                 105                 110         


Gly Glu Met Glu Ala Asp Val Gln Ala Leu Val Arg Arg Ala Ala Arg 
        115                 120                 125             


Gln Leu Ala Glu Ser Gly Thr Pro Ser Leu Thr Ala Ala Val Leu His 
    130                 135                 140                 


Thr Ile His Val Leu Ser Ala Tyr Ala Ser Ile Gly Pro Leu Thr Gly 
145                 150                 155                 160 


Val Phe Arg Glu Thr Gly Ala Leu Asp Leu Leu Met His Met Leu Cys 
                165                 170                 175     


Asn Pro Glu Pro Gln Ile Arg Arg Ser Ala Gly Lys Met Leu Gln Ala 
            180                 185                 190         


Leu Ala Ala His Asp Ala Gly Ser Arg Ala His Val Leu Leu Ser Leu 
        195                 200                 205             


Ser Gln Gln Asp Gly Ile Glu Gln His Met Asp Phe Asp Ser Arg Tyr 
    210                 215                 220                 


Thr Leu Leu Glu Leu Phe Ala Glu Thr Thr Ser Ser Glu Glu His Cys 
225                 230                 235                 240 


Met Ala Phe Glu Gly Ile His Leu Pro Gln Ile Pro Gly Lys Leu Leu 
                245                 250                 255     


Phe Ser Leu Val Lys Arg Tyr Leu Cys Val Thr Ser Leu Leu Asp Gln 
            260                 265                 270         


Leu Asn Ser Ser Pro Glu Leu Gly Ala Gly Asp Gln Ser Ser Pro Cys 
        275                 280                 285             


Ala Thr Arg Glu Lys Ser Arg Gly Gln Arg Glu Leu Glu Phe Ser Met 
    290                 295                 300                 


Ala Val Gly Asn Leu Ile Ser Glu Leu Val Arg Ser Met Gly Trp Ala 
305                 310                 315                 320 


Arg Asn Leu Ser Glu Gln Gly Met Ser Pro Pro Arg Pro Thr Arg Ser 
                325                 330                 335     


Ile Phe Gln Pro Tyr Ile Ser Gly Pro Ser Leu Leu Leu Pro Thr Ile 
            340                 345                 350         


Val Thr Thr Pro Arg Arg Gln Gly Trp Val Phe Arg Gln Arg Ser Glu 
        355                 360                 365             


Phe Ser Ser Arg Ser Gly Tyr Gly Glu Tyr Val Gln Gln Thr Leu Gln 
    370                 375                 380                 


Pro Gly Met Arg Val Arg Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala 
385                 390                 395                 400 


Gly Asp Glu Gly Glu Phe Arg Gln Ser Asn Asn Gly Ile Pro Pro Val 
                405                 410                 415     


Gln Thr Leu Gly Glu Lys Ala Leu Gly Glu Ile Ser Val Ser Val Glu 
            420                 425                 430         


Met Ala Glu Ser Leu Leu Gln Val Leu Ser Ser Arg Phe Glu Gly Ser 
        435                 440                 445             


Thr Leu Asn Asp Leu Leu Asn Ser Gln Ile Tyr Thr Lys Tyr Gly Leu 
    450                 455                 460                 


Leu Ser Asn Glu Pro Ser Ser Ser Ser Thr Ser Arg Asn His Ser Cys 
465                 470                 475                 480 


Thr Pro Asp Pro Glu Glu Glu Ser Lys Ser Glu Ala Ser Phe Ser Glu 
                485                 490                 495     


Glu Glu Thr Glu Ser Leu Lys Ala Lys Ala Glu Ala Pro Lys Thr Glu 
            500                 505                 510         


Ala Glu Pro Thr Lys Thr Arg Thr Glu Thr Pro Met Ala Gln Ser Asp 
        515                 520                 525             


Ser Gln Leu Phe Asn Gln Leu Leu Val Thr Glu Gly Met Thr Leu Pro 
    530                 535                 540                 


Thr Glu Met Lys Glu Ala Ala Ser Glu Met Ala Arg Ala Leu Arg Gly 
545                 550                 555                 560 


Pro Gly Pro Arg Ser Ser Leu Asp Gln His Val Ala Ala Val Val Ala 
                565                 570                 575     


Thr Val Gln Ile Ser Ser Leu Asp Thr Asn Leu Gln Leu Ser Gly Leu 
            580                 585                 590         


Ser Ala Leu Ser Gln Ala Val Glu Glu Val Thr Glu Arg Asp His Pro 
        595                 600                 605             


Leu Val Arg Pro Asp Arg Ser Leu Arg Glu Lys Leu Val Lys Met Leu 
    610                 615                 620                 


Val Glu Leu Leu Thr Asn Gln Val Gly Glu Lys Met Val Val Val Gln 
625                 630                 635                 640 


Ala Leu Arg Leu Leu Tyr Leu Leu Met Thr Lys His Glu Trp Arg Pro 
                645                 650                 655     


Leu Phe Ala Arg Glu Gly Gly Ile Tyr Ala Val Leu Val Cys Met Gln 
            660                 665                 670         


Glu Tyr Lys Thr Ser Val Leu Val Gln Gln Ala Gly Leu Ala Ala Leu 
        675                 680                 685             


Lys Met Leu Ala Val Ala Ser Ser Ser Glu Ile Pro Thr Phe Val Thr 
    690                 695                 700                 


Gly Arg Asp Ser Ile His Ser Leu Phe Asp Ala Gln Met Thr Arg Glu 
705                 710                 715                 720 


Ile Phe Ala Ser Ile Asp Ser Ala Thr Arg Pro Gly Ser Glu Ser Leu 
                725                 730                 735     


Leu Leu Thr Val Pro Ala Ala Val Ile Leu Met Leu Asn Thr Glu Gly 
            740                 745                 750         


Cys Ser Ser Ala Ala Arg Asn Gly Leu Leu Leu Leu Asn Leu Leu Leu 
        755                 760                 765             


Cys Asn His His Thr Leu Gly Asp Gln Ile Ile Thr Gln Glu Leu Arg 
    770                 775                 780                 


Asp Thr Leu Phe Arg His Ser Gly Ile Ala Pro Arg Thr Glu Pro Met 
785                 790                 795                 800 


Pro Thr Thr Arg Thr Ile Leu Met Met Leu Leu Asn Arg Tyr Ser Glu 
                805                 810                 815     


Pro Pro Gly Ser Pro Glu Arg Ala Ala Leu Glu Thr Pro Ile Ile Gln 
            820                 825                 830         


Gly Gln Asp Gly Ser Pro Glu Leu Leu Ile Arg Ser Leu Val Gly Gly 
        835                 840                 845             


Pro Ser Ala Glu Leu Leu Leu Asp Leu Glu Arg Val Leu Cys Arg Glu 
    850                 855                 860                 


Gly Ser Pro Gly Gly Ala Val Arg Pro Leu Leu Lys Arg Leu Gln Gln 
865                 870                 875                 880 


Glu Thr Gln Pro Phe Leu Leu Leu Leu Arg Thr Leu Asp Ala Pro Gly 
                885                 890                 895     


Pro Asn Lys Thr Leu Leu Leu Ser Val Leu Arg Val Ile Thr Arg Leu 
            900                 905                 910         


Leu Asp Phe Pro Glu Ala Met Val Leu Pro Trp His Glu Val Leu Glu 
        915                 920                 925             


Pro Cys Leu Asn Cys Leu Ser Gly Pro Ser Ser Asp Ser Glu Ile Val 
    930                 935                 940                 


Gln Glu Leu Thr Cys Phe Leu His Arg Leu Ala Ser Met His Lys Asp 
945                 950                 955                 960 


Tyr Ala Val Val Leu Cys Cys Leu Gly Ala Lys Glu Ile Leu Ser Lys 
                965                 970                 975     


Val Leu Asp Lys His Ser Ala Gln Leu Leu Leu Gly Cys Glu Leu Arg 
            980                 985                 990         


Asp Leu Val Thr Glu Cys Glu Lys  Tyr Ala Gln Leu Tyr  Ser Asn Leu 
        995                 1000                 1005             


Thr Ser  Ser Ile Leu Ala Gly  Cys Ile Gln Met Val  Leu Gly Gln 
    1010                 1015                 1020             


Ile Glu  Asp His Arg Arg Thr  His Gln Pro Ile Asn  Ile Pro Phe 
    1025                 1030                 1035             


Phe Asp  Val Phe Leu Arg His  Leu Cys Gln Gly Ser  Ser Val Glu 
    1040                 1045                 1050             


Val Lys  Glu Asp Lys Cys Trp  Glu Lys Val Glu Val  Ser Ser Asn 
    1055                 1060                 1065             


Pro His  Arg Ala Ser Lys Leu  Thr Asp His Asn Pro  Lys Thr Tyr 
    1070                 1075                 1080             


Trp Glu  Ser Asn Gly Ser Thr  Gly Ser His Tyr Ile  Thr Leu His 
    1085                 1090                 1095             


Met His  Arg Gly Val Leu Val  Arg Gln Leu Thr Leu  Leu Val Ala 
    1100                 1105                 1110             


Ser Glu  Asp Ser Ser Tyr Met  Pro Ala Arg Val Val  Val Phe Gly 
    1115                 1120                 1125             


Gly Asp  Ser Thr Ser Cys Ile  Gly Thr Glu Leu Asn  Thr Val Asn 
    1130                 1135                 1140             


Val Met  Pro Ser Ala Ser Arg  Val Ile Leu Leu Glu  Asn Leu Asn 
    1145                 1150                 1155             


Arg Phe  Trp Pro Ile Ile Gln  Ile Arg Ile Lys Arg  Cys Gln Gln 
    1160                 1165                 1170             


Gly Gly  Ile Asp Thr Arg Val  Arg Gly Val Glu Val  Leu Gly Pro 
    1175                 1180                 1185             


Lys Pro  Thr Phe Trp Pro Leu  Phe Arg Glu Gln Leu  Cys Arg Arg 
    1190                 1195                 1200             


Thr Cys  Leu Phe Tyr Thr Ile  Arg Ala Gln Ala Trp  Ser Arg Asp 
    1205                 1210                 1215             


Ile Ala  Glu Asp His Arg Arg  Leu Leu Gln Leu Cys  Pro Arg Leu 
    1220                 1225                 1230             


Asn Arg  Val Leu Arg His Glu  Gln Asn Phe Ala Asp  Arg Phe Leu 
    1235                 1240                 1245             


Pro Asp  Asp Glu Ala Ala Gln  Ala Leu Gly Lys Thr  Cys Trp Glu 
    1250                 1255                 1260             


Ala Leu  Val Ser Pro Leu Val  Gln Asn Ile Thr Ser  Pro Asp Ala 
    1265                 1270                 1275             


Glu Gly  Val Ser Ala Leu Gly  Trp Leu Leu Asp Gln  Tyr Leu Glu 
    1280                 1285                 1290             


Gln Arg  Glu Thr Ser Arg Asn  Pro Leu Ser Arg Ala  Ala Ser Phe 
    1295                 1300                 1305             


Ala Ser  Arg Val Arg Arg Leu  Cys His Leu Leu Val  His Val Glu 
    1310                 1315                 1320             


Pro Pro  Pro Gly Pro Ser Pro  Glu Pro Ser Thr Arg  Pro Phe Ser 
    1325                 1330                 1335             


Lys Asn  Ser Lys Gly Arg Asp  Arg Ser Pro Ala Pro  Ser Pro Val 
    1340                 1345                 1350             


Leu Pro  Ser Ser Ser Leu Arg  Asn Ile Thr Gln Cys  Trp Leu Ser 
    1355                 1360                 1365             


Val Val  Gln Glu Gln Val Ser  Arg Phe Leu Ala Ala  Ala Trp Arg 
    1370                 1375                 1380             


Ala Pro  Asp Phe Val Pro Arg  Tyr Cys Lys Leu Tyr  Glu His Leu 
    1385                 1390                 1395             


Gln Arg  Ala Gly Ser Glu Leu  Phe Gly Pro Arg Ala  Ala Phe Met 
    1400                 1405                 1410             


Leu Ala  Leu Arg Ser Gly Phe  Ser Gly Ala Leu Leu  Gln Gln Ser 
    1415                 1420                 1425             


Phe Leu  Thr Ala Ala His Met  Ser Glu Gln Phe Ala  Arg Tyr Ile 
    1430                 1435                 1440             


Asp Gln  Gln Ile Gln Gly Gly  Leu Ile Gly Gly Ala  Pro Gly Val 
    1445                 1450                 1455             


Glu Met  Leu Gly Gln Leu Gln  Arg His Leu Glu Pro  Ile Met Val 
    1460                 1465                 1470             


Leu Ser  Gly Leu Glu Leu Ala  Thr Thr Phe Glu His  Phe Tyr Gln 
    1475                 1480                 1485             


His Tyr  Met Ala Asp Arg Leu  Leu Ser Phe Gly Ser  Ser Trp Leu 
    1490                 1495                 1500             


Glu Gly  Ala Val Leu Glu Gln  Ile Gly Leu Cys Phe  Pro Asn Arg 
    1505                 1510                 1515             


Leu Pro  Gln Leu Met Leu Gln  Ser Leu Ser Thr Ser  Glu Glu Leu 
    1520                 1525                 1530             


Gln Arg  Gln Phe His Leu Phe  Gln Leu Gln Arg Leu  Asp Lys Leu 
    1535                 1540                 1545             


Phe Leu  Glu Gln Glu Asp Glu  Glu Glu Lys Arg Leu  Glu Glu Glu 
    1550                 1555                 1560             


Glu Glu  Glu Glu Glu Glu Glu  Glu Ala Glu Lys Glu  Leu Phe Ile 
    1565                 1570                 1575             


Glu Asp  Pro Ser Pro Ala Ile  Ser Ile Leu Val Leu  Ser Pro Arg 
    1580                 1585                 1590             


Cys Trp  Pro Val Ser Pro Leu  Cys Tyr Leu Tyr His  Pro Arg Lys 
    1595                 1600                 1605             


Cys Leu  Pro Thr Glu Phe Cys  Asp Ala Leu Asp Arg  Phe Ser Ser 
    1610                 1615                 1620             


Phe Tyr  Ser Gln Ser Gln Asn  His Pro Val Leu Asp  Met Gly Pro 
    1625                 1630                 1635             


His Arg  Arg Leu Gln Trp Thr  Trp Leu Gly Arg Ala  Glu Leu Gln 
    1640                 1645                 1650             


Phe Gly  Lys Gln Ile Leu His  Val Ser Thr Val Gln  Met Trp Leu 
    1655                 1660                 1665             


Leu Leu  Lys Phe Asn Gln Thr  Glu Glu Val Ser Val  Glu Thr Leu 
    1670                 1675                 1680             


Leu Lys  Asp Ser Asp Leu Ser  Pro Glu Leu Leu Leu  Gln Ala Leu 
    1685                 1690                 1695             


Val Pro  Leu Thr Ser Gly Asn  Gly Pro Leu Thr Leu  His Glu Gly 
    1700                 1705                 1710             


Gln Asp  Phe Pro His Gly Gly  Val Leu Arg Leu His  Glu Pro Gly 
    1715                 1720                 1725             


Pro Gln  Arg Ser Gly Glu Ala  Leu Trp Leu Ile Pro  Pro Gln Ala 
    1730                 1735                 1740             


Tyr Leu  Asn Val Glu Lys Asp  Glu Gly Arg Thr Leu  Glu Gln Lys 
    1745                 1750                 1755             


Arg Asn  Leu Leu Ser Cys Leu  Leu Val Arg Ile Leu  Lys Ala His 
    1760                 1765                 1770             


Gly Glu  Lys Gly Leu His Ile  Asp Gln Leu Val Cys  Leu Val Leu 
    1775                 1780                 1785             


Glu Ala  Trp Gln Lys Gly Pro  Asn Pro Pro Gly Thr  Leu Gly His 
    1790                 1795                 1800             


Thr Val  Ala Gly Gly Val Ala  Cys Thr Ser Thr Asp  Val Leu Ser 
    1805                 1810                 1815             


Cys Ile  Leu His Leu Leu Gly  Gln Gly Tyr Val Lys  Arg Arg Asp 
    1820                 1825                 1830             


Asp Arg  Pro Gln Ile Leu Met  Tyr Ala Ala Pro Glu  Pro Met Gly 
    1835                 1840                 1845             


Pro Cys  Arg Gly Gln Ala Asp  Val Pro Phe Cys Gly  Ser Gln Ser 
    1850                 1855                 1860             


Glu Thr  Ser Lys Pro Ser Pro  Glu Ala Val Ala Thr  Leu Ala Ser 
    1865                 1870                 1875             


Leu Gln  Leu Pro Ala Gly Arg  Thr Met Ser Pro Gln  Glu Val Glu 
    1880                 1885                 1890             


Gly Leu  Met Lys Gln Thr Val  Arg Gln Val Gln Glu  Thr Leu Asn 
    1895                 1900                 1905             


Leu Glu  Pro Asp Val Ala Gln  His Leu Leu Ala His  Ser His Trp 
    1910                 1915                 1920             


Gly Ala  Glu Gln Leu Leu Gln  Ser Tyr Ser Glu Asp  Pro Glu Pro 
    1925                 1930                 1935             


Leu Leu  Leu Ala Ala Gly Leu  Cys Val His Gln Ala  Gln Ala Val 
    1940                 1945                 1950             


Pro Val  Arg Pro Asp His Cys  Pro Val Cys Val Ser  Pro Leu Gly 
    1955                 1960                 1965             


Cys Asp  Asp Asp Leu Pro Ser  Leu Cys Cys Met His  Tyr Cys Cys 
    1970                 1975                 1980             


Lys Ser  Cys Trp Asn Glu Tyr  Leu Thr Thr Arg Ile  Glu Gln Asn 
    1985                 1990                 1995             


Leu Val  Leu Asn Cys Thr Cys  Pro Ile Ala Asp Cys  Pro Ala Gln 
    2000                 2005                 2010             


Pro Thr  Gly Ala Phe Ile Arg  Ala Ile Val Ser Ser  Pro Glu Val 
    2015                 2020                 2025             


Ile Ser  Lys Tyr Glu Lys Ala  Leu Leu Arg Gly Tyr  Val Glu Ser 
    2030                 2035                 2040             


Cys Ser  Asn Leu Thr Trp Cys  Thr Asn Pro Gln Gly  Cys Asp Arg 
    2045                 2050                 2055             


Ile Leu  Cys Arg Gln Gly Leu  Gly Cys Gly Thr Thr  Cys Ser Lys 
    2060                 2065                 2070             


Cys Gly  Trp Ala Ser Cys Phe  Asn Cys Ser Phe Pro  Glu Ala His 
    2075                 2080                 2085             


Tyr Pro  Ala Ser Cys Gly His  Met Ser Gln Trp Val  Asp Asp Gly 
    2090                 2095                 2100             


Gly Tyr  Tyr Asp Gly Met Ser  Val Glu Ala Gln Ser  Lys His Leu 
    2105                 2110                 2115             


Ala Lys  Leu Ile Ser Lys Arg  Cys Pro Ser Cys Gln  Ala Pro Ile 
    2120                 2125                 2130             


Glu Lys  Asn Glu Gly Cys Leu  His Met Thr Cys Ala  Lys Cys Asn 
    2135                 2140                 2145             


His Gly  Phe Cys Trp Arg Cys  Leu Lys Ser Trp Lys  Pro Asn His 
    2150                 2155                 2160             


Lys Asp  Tyr Tyr Asn Cys Ser  Ala Met Val Ser Lys  Ala Ala Arg 
    2165                 2170                 2175             


Gln Glu  Lys Arg Phe Gln Asp  Tyr Asn Glu Arg Cys  Thr Phe His 
    2180                 2185                 2190             


His Gln  Ala Arg Glu Phe Ala  Val Asn Leu Arg Asn  Arg Val Ser 
    2195                 2200                 2205             


Ala Ile  His Glu Val Pro Pro  Pro Arg Ser Phe Thr  Phe Leu Asn 
    2210                 2215                 2220             


Asp Ala  Cys Gln Gly Leu Glu  Gln Ala Arg Lys Val  Leu Ala Tyr 
    2225                 2230                 2235             


Ala Cys  Val Tyr Ser Phe Tyr  Ser Gln Asp Ala Glu  Tyr Met Asp 
    2240                 2245                 2250             


Val Val  Glu Gln Gln Thr Glu  Asn Leu Glu Leu His  Thr Asn Ala 
    2255                 2260                 2265             


Leu Gln  Ile Leu Leu Glu Glu  Thr Leu Leu Arg Cys  Arg Asp Leu 
    2270                 2275                 2280             


Ala Ser  Ser Leu Arg Leu Leu  Arg Ala Asp Cys Leu  Ser Thr Gly 
    2285                 2290                 2295             


Met Glu  Leu Leu Arg Arg Ile  Gln Glu Arg Leu Leu  Ala Ile Leu 
    2300                 2305                 2310             


Gln His  Ser Ala Gln Asp Phe  Arg Val Gly Leu Gln  Ser Pro Ser 
    2315                 2320                 2325             


Val Glu  Ala Trp Glu Ala Lys  Gly Pro Asn Met Pro  Gly Ser Gln 
    2330                 2335                 2340             


Pro Gln  Ala Ser Ser Gly Pro  Glu Ala Glu Glu Glu  Glu Glu Asp 
    2345                 2350                 2355             


Asp Glu  Asp Asp Val Pro Glu  Trp Gln Gln Asp Glu  Phe Asp Glu 
    2360                 2365                 2370             


Glu Leu  Asp Asn Asp Ser Phe  Ser Tyr Asp Glu Ser  Glu Asn Leu 
    2375                 2380                 2385             


Asp Gln  Glu Thr Phe Phe Phe  Gly Asp Glu Glu Glu  Asp Glu Asp 
    2390                 2395                 2400             


Glu Ala  Tyr Asp 
    2405         


<210> 5857
<211> 223
<212> PRT
<213> Homo sapiens

<400> 5857
Met Glu Asp Val Lys Leu Glu Phe Pro Ser Leu Pro Gln Cys Lys Glu 
1               5                   10                  15      


Asp Ala Glu Glu Trp Thr Tyr Pro Met Arg Arg Glu Met Gln Glu Ile 
            20                  25                  30          


Leu Pro Gly Leu Phe Leu Gly Pro Tyr Ser Ser Ala Met Lys Ser Lys 
        35                  40                  45              


Leu Pro Val Leu Gln Lys His Gly Ile Thr His Ile Ile Cys Ile Arg 
    50                  55                  60                  


Gln Asn Ile Glu Ala Asn Phe Ile Lys Pro Asn Phe Gln Gln Leu Phe 
65                  70                  75                  80  


Arg Tyr Leu Val Leu Asp Ile Ala Asp Asn Pro Val Glu Asn Ile Ile 
                85                  90                  95      


Arg Phe Phe Pro Met Thr Lys Glu Phe Ile Asp Gly Ser Leu Gln Met 
            100                 105                 110         


Gly Gly Lys Val Leu Val His Gly Asn Ala Gly Ile Ser Arg Ser Ala 
        115                 120                 125             


Ala Phe Val Ile Ala Tyr Ile Met Glu Thr Phe Gly Met Lys Tyr Arg 
    130                 135                 140                 


Asp Ala Phe Ala Tyr Val Gln Glu Arg Arg Phe Cys Ile Asn Pro Asn 
145                 150                 155                 160 


Ala Gly Phe Val His Gln Leu Gln Glu Tyr Glu Ala Ile Tyr Leu Ala 
                165                 170                 175     


Lys Leu Thr Ile Gln Met Met Ser Pro Leu Gln Ile Glu Arg Ser Leu 
            180                 185                 190         


Ser Val His Ser Gly Thr Thr Gly Ser Leu Lys Arg Thr His Glu Glu 
        195                 200                 205             


Glu Asp Asp Phe Gly Thr Met Gln Val Ala Thr Ala Gln Asn Gly 
    210                 215                 220             


<210> 5858
<211> 562
<212> PRT
<213> Homo sapiens

<400> 5858
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Cys Met Tyr His Leu Gly Val Gly Leu Leu Asp Pro Ser Arg Ser 
    530                 535                 540                 


Phe Trp Ile Ala Ile Pro Trp Ala Cys Pro Gly Leu Gly Val Ala Ala 
545                 550                 555                 560 


Leu Cys 
        


<210> 5859
<211> 119
<212> PRT
<213> Homo sapiens

<400> 5859
Met Ile Leu Gln Gln Pro Leu Gln Arg Gly Pro Gln Gly Gly Ala Gln 
1               5                   10                  15      


Arg Leu Pro Arg Ala Ala Leu Gly Val Thr Trp Gly Leu Asp Ala Arg 
            20                  25                  30          


Glu Pro Leu Arg Lys Gln Phe Leu Ser Glu Glu Asn Met Ala Thr His 
        35                  40                  45              


Phe Ser Gln Leu Ser Leu His Asn Asp His Pro Tyr Cys Ser Pro Pro 
    50                  55                  60                  


Met Thr Phe Ser Pro Ala Leu Pro Pro Leu Arg Ser Pro Cys Ser Glu 
65                  70                  75                  80  


Leu Leu Leu Trp Arg Tyr Pro Gly Ser Leu Ile Pro Glu Ala Leu Arg 
                85                  90                  95      


Leu Leu Arg Leu Gly Asp Thr Pro Ser Pro Pro Tyr Pro Ala Thr Pro 
            100                 105                 110         


Ala Gly Asp Ile Met Glu Leu 
        115                 


<210> 5860
<211> 597
<212> PRT
<213> Homo sapiens

<400> 5860
Met Val Pro Glu Glu Arg Arg Val Gly Leu Ser Ser Asp Glu Thr Ser 
1               5                   10                  15      


Ser Asp Ser Leu Lys Ser Trp His Ser Ile Cys Val Leu Asp Ser Lys 
            20                  25                  30          


Glu Gln Pro Leu Ala Cys Gln Gln Lys Gln Arg Gln Phe Val Lys Pro 
        35                  40                  45              


Val Thr Glu Ser Glu Gln Pro Thr Val Leu Glu Leu Leu Leu Ala Glu 
    50                  55                  60                  


Leu Arg Thr Leu Phe Ser Ala Val Leu Gln Asp Ser Ser Pro Ala Ala 
65                  70                  75                  80  


Trp Arg Tyr Leu His Ala Val Leu Gly Leu Leu Pro Pro Tyr Arg Glu 
                85                  90                  95      


Leu Leu Val Gly His Leu Asp Leu Leu Pro Phe Leu Glu Gln Leu Tyr 
            100                 105                 110         


Cys Trp Ala Pro Trp Val Gln Thr His Leu His Leu Asp Leu Leu Gly 
        115                 120                 125             


Ala Ile Val Gln Ala Phe Pro Pro Asp Ser Ser Leu Leu Asp Ser Ala 
    130                 135                 140                 


Ser His Ala Asp Cys Cys Pro Gln Lys Arg Arg Leu His His Arg Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Cys Pro Phe Val Gln Ala Gln Trp Ser Arg Gln Gln 
                165                 170                 175     


Val Lys Glu Glu Leu Ala Thr Trp Leu Arg Pro Leu Thr Leu Pro Glu 
            180                 185                 190         


Leu Gln Arg Cys Leu Gly Ile Val Gly Ala Gln Val Ala Leu Glu Glu 
        195                 200                 205             


Ala Val Trp Leu Asp Gly Leu Ser Leu Leu Pro Leu Ala Leu Ala Ala 
    210                 215                 220                 


Asp Ile Pro Val Arg Tyr Glu Ser Ser Asp Thr Asp Asn Ala Glu Val 
225                 230                 235                 240 


Glu Pro Val Gly Arg Lys Glu Thr Arg Ser Gln Leu Asp Tyr Glu Val 
                245                 250                 255     


Pro Arg Glu Lys Ala Phe Gln Lys Ser Ser Thr Gly Phe Ser Pro Glu 
            260                 265                 270         


Thr Ser Phe Leu Asp Ser Gln Val Met Thr Ala Leu Lys Met Glu Arg 
        275                 280                 285             


Tyr Leu Lys Lys Ile His Phe Leu Tyr Leu Asn Val Ala Pro Ser Arg 
    290                 295                 300                 


Tyr Phe Arg Pro Tyr Ser Leu Met Val Val Pro Pro Asp Lys Val Asn 
305                 310                 315                 320 


Pro Glu His Tyr Ile Phe Ser Pro Phe Gly Ile Leu His Val His Pro 
                325                 330                 335     


Val Glu Gly Ser Glu Thr Met Thr Leu Gly Thr Trp His His His Cys 
            340                 345                 350         


Val Leu Trp Gln Gln Leu Gln Phe Ile Pro Phe Phe Lys Tyr Cys Leu 
        355                 360                 365             


Leu Arg Lys Ser Phe Thr Cys Trp Lys Lys Asn Val Arg Leu Gln Gly 
    370                 375                 380                 


Leu His Arg Leu Gln Lys Phe Leu Glu Asn His Leu Leu Leu Ala Val 
385                 390                 395                 400 


Pro His Phe Gly Ala Gly Leu Leu His Ile Ser Arg Leu Leu Gln Glu 
                405                 410                 415     


Leu His Ser Val Ser Trp Leu Pro Gln Glu Leu Asp Arg Cys Tyr Glu 
            420                 425                 430         


Leu Leu Asp Leu Gln Thr Ala Leu Ala Glu Glu Lys His Lys Ala Leu 
        435                 440                 445             


Arg Leu Leu His Arg Cys Leu Asn Leu Cys Thr Ser Ile Leu Arg Leu 
    450                 455                 460                 


Val His Glu Asp Thr Tyr His Met Gln Gln Cys Leu Gln Glu Arg Val 
465                 470                 475                 480 


Gln Asn Cys Asp Arg Ile Arg Thr Gly Gln Gly Ser Ile Tyr Leu Gln 
                485                 490                 495     


Arg Val Gln His Lys Gln Leu Glu Gln Lys Leu Lys Gln Ala Glu Ala 
            500                 505                 510         


Trp Trp Leu Gln Leu Gly Lys Phe Ala Arg Leu Val Asp Tyr Met Ile 
        515                 520                 525             


Cys Gln Ser Leu Ile Ser Val Leu Glu Glu Gln Ile Thr Ser Phe Val 
    530                 535                 540                 


Ala Asn Ile Leu Gln Ala Pro Arg Gln Lys Pro Phe Leu Ser Ser Gln 
545                 550                 555                 560 


Leu Val Phe Asp Asp His Gly Gln Leu Ser His Val Pro Cys Val Glu 
                565                 570                 575     


Asn Met Ile Gln Thr Leu Thr Gly Gly Leu Gln Ser Val Lys Thr Ser 
            580                 585                 590         


Ala Leu Gln Val Phe 
        595         


<210> 5861
<211> 196
<212> PRT
<213> Homo sapiens

<400> 5861
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala 
    130                 135                 140                 


Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr 
145                 150                 155                 160 


Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp 
                165                 170                 175     


Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys 
            180                 185                 190         


Lys Thr Val Cys 
        195     


<210> 5862
<211> 295
<212> PRT
<213> Homo sapiens

<400> 5862
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 5863
<211> 304
<212> PRT
<213> Homo sapiens

<400> 5863
Met Lys Arg Ala His Pro Glu Tyr Ser Ser Ser Asp Ser Glu Leu Asp 
1               5                   10                  15      


Glu Thr Ile Glu Val Glu Lys Glu Ser Ala Asp Glu Asn Gly Asn Leu 
            20                  25                  30          


Ser Ser Ala Leu Gly Ser Met Ser Pro Thr Thr Ser Ser Gln Ile Leu 
        35                  40                  45              


Ala Arg Lys Arg Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg 
    50                  55                  60                  


Ile Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Ser Ala Phe 
65                  70                  75                  80  


Glu Lys Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu Ile Leu Gln Met 
                85                  90                  95      


Thr Val Asp His Leu Lys Met Leu His Thr Ala Gly Gly Lys Gly Tyr 
            100                 105                 110         


Phe Asp Ala His Ala Leu Ala Met Asp Tyr Arg Ser Leu Gly Phe Arg 
        115                 120                 125             


Glu Cys Leu Ala Glu Val Ala Arg Tyr Leu Ser Ile Ile Glu Gly Leu 
    130                 135                 140                 


Asp Ala Ser Asp Pro Leu Arg Val Arg Leu Val Ser His Leu Asn Asn 
145                 150                 155                 160 


Tyr Ala Ser Gln Arg Glu Ala Ala Ser Gly Ala His Ala Gly Leu Gly 
                165                 170                 175     


His Ile Pro Trp Gly Thr Val Phe Gly His His Pro His Ile Ala His 
            180                 185                 190         


Pro Leu Leu Leu Pro Gln Asn Gly His Gly Asn Ala Gly Thr Thr Ala 
        195                 200                 205             


Ser Pro Thr Glu Pro His His Gln Gly Arg Leu Gly Ser Ala His Pro 
    210                 215                 220                 


Glu Ala Pro Ala Leu Arg Ala Pro Pro Ser Gly Ser Leu Gly Pro Val 
225                 230                 235                 240 


Leu Pro Val Val Thr Ser Ala Ser Lys Leu Ser Pro Pro Leu Leu Ser 
                245                 250                 255     


Ser Val Ala Ser Leu Ser Ala Phe Pro Phe Ser Phe Gly Ser Phe His 
            260                 265                 270         


Leu Leu Ser Pro Asn Ala Leu Ser Pro Ser Ala Pro Thr Gln Ala Ala 
        275                 280                 285             


Asn Leu Gly Lys Pro Tyr Arg Pro Trp Gly Thr Glu Ile Gly Ala Phe 
    290                 295                 300                 


<210> 5864
<211> 842
<212> PRT
<213> Homo sapiens

<400> 5864
Met Cys Gly Ser Glu Arg Ile Leu Gln Ala Gly Asn Ile Leu Glu Ile 
1               5                   10                  15      


Arg Val Gly Gln Ala Gly Ala Arg Arg Val Ala Thr Met Thr Ser Pro 
            20                  25                  30          


Val Leu Val Asp Ile Arg Glu Glu Val Thr Cys Pro Ile Cys Leu Glu 
        35                  40                  45              


Leu Leu Thr Glu Pro Leu Ser Ile Asp Cys Gly His Ser Phe Cys Gln 
    50                  55                  60                  


Ala Cys Ile Thr Pro Asn Gly Arg Glu Ser Val Ile Gly Gln Glu Gly 
65                  70                  75                  80  


Glu Arg Ser Cys Pro Val Cys Gln Thr Ser Tyr Gln Pro Gly Asn Leu 
                85                  90                  95      


Arg Pro Asn Arg His Leu Ala Asn Ile Val Arg Arg Leu Arg Glu Val 
            100                 105                 110         


Val Leu Gly Pro Gly Lys Gln Leu Lys Ala Val Leu Cys Ala Asp His 
        115                 120                 125             


Gly Glu Lys Leu Gln Leu Phe Cys Gln Glu Asp Gly Lys Val Ile Cys 
    130                 135                 140                 


Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr Phe Leu 
145                 150                 155                 160 


Val Glu Glu Val Ala Gln Glu Tyr Gln Glu Lys Phe Gln Glu Ser Leu 
                165                 170                 175     


Lys Lys Leu Lys Asn Glu Glu Gln Glu Ala Glu Lys Leu Thr Ala Phe 
            180                 185                 190         


Ile Arg Glu Lys Lys Thr Ser Trp Lys Asn Gln Met Glu Pro Glu Arg 
        195                 200                 205             


Cys Arg Ile Gln Thr Glu Phe Asn Gln Leu Arg Asn Ile Leu Asp Arg 
    210                 215                 220                 


Val Glu Gln Arg Glu Leu Lys Lys Leu Glu Gln Glu Glu Lys Lys Gly 
225                 230                 235                 240 


Leu Arg Ile Ile Glu Glu Ala Glu Asn Asp Leu Val His Gln Thr Gln 
                245                 250                 255     


Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu Arg Arg Cys Gln Gly Ser 
            260                 265                 270         


Thr Met Glu Leu Leu Gln Asp Val Ser Asp Val Thr Glu Arg Ser Glu 
        275                 280                 285             


Phe Trp Thr Leu Arg Lys Pro Glu Ala Leu Pro Thr Lys Leu Arg Ser 
    290                 295                 300                 


Met Phe Arg Ala Pro Asp Leu Lys Arg Met Leu Arg Val Cys Arg Glu 
305                 310                 315                 320 


Leu Thr Asp Val Gln Ser Tyr Trp Ala Ile Gln Gly Ser Leu Thr Arg 
                325                 330                 335     


Arg Glu Arg Arg Ala Ser Gly Val Arg Thr Arg Arg Ser Gln Gly Ser 
            340                 345                 350         


Ser Ala Met Ala Ser Lys Ile Leu Leu Asn Val Gln Glu Glu Val Thr 
        355                 360                 365             


Cys Pro Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys 
    370                 375                 380                 


Gly His Ser Leu Cys Arg Ala Cys Ile Thr Val Ser Asn Lys Glu Ala 
385                 390                 395                 400 


Val Thr Ser Met Gly Gly Lys Ser Ser Cys Pro Val Cys Gly Ile Ser 
                405                 410                 415     


Tyr Ser Phe Glu His Leu Gln Ala Asn Gln His Leu Ala Asn Ile Val 
            420                 425                 430         


Glu Arg Leu Lys Glu Val Lys Leu Ser Pro Asp Asn Gly Lys Lys Arg 
        435                 440                 445             


Asp Leu Cys Asp His His Gly Glu Lys Leu Leu Leu Phe Cys Lys Glu 
    450                 455                 460                 


Asp Arg Lys Val Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg 
465                 470                 475                 480 


Gly His His Thr Val Leu Thr Glu Glu Val Phe Lys Glu Cys Gln Glu 
                485                 490                 495     


Lys Leu Gln Ala Val Leu Lys Arg Leu Lys Lys Glu Glu Glu Glu Ala 
            500                 505                 510         


Glu Lys Leu Glu Ala Asp Ile Arg Glu Glu Lys Thr Ser Trp Lys Tyr 
        515                 520                 525             


Gln Val Gln Thr Glu Arg Gln Arg Ile Gln Thr Glu Phe Asp Gln Leu 
    530                 535                 540                 


Arg Ser Ile Leu Asn Asn Glu Glu Gln Arg Glu Leu Gln Arg Leu Glu 
545                 550                 555                 560 


Glu Glu Glu Lys Lys Thr Leu Asp Lys Phe Ala Glu Ala Glu Asp Glu 
                565                 570                 575     


Leu Val Gln Gln Lys Gln Leu Val Arg Glu Leu Ile Ser Asp Val Glu 
            580                 585                 590         


Cys Arg Ser Gln Trp Ser Thr Met Glu Leu Leu Gln Asp Met Ser Gly 
        595                 600                 605             


Ile Met Lys Trp Ser Glu Ile Trp Arg Leu Lys Lys Pro Lys Met Val 
    610                 615                 620                 


Ser Lys Lys Leu Lys Thr Val Phe His Ala Pro Asp Leu Ser Arg Met 
625                 630                 635                 640 


Leu Gln Met Phe Arg Glu Leu Thr Ala Val Arg Cys Tyr Trp Val Asp 
                645                 650                 655     


Val Thr Leu Asn Ser Val Asn Leu Asn Leu Asn Leu Val Leu Ser Glu 
            660                 665                 670         


Asp Gln Arg Gln Val Ile Ser Val Pro Ile Trp Pro Phe Gln Cys Tyr 
        675                 680                 685             


Asn Tyr Gly Val Leu Gly Ser Gln Tyr Phe Ser Ser Gly Lys His Tyr 
    690                 695                 700                 


Trp Glu Val Asp Val Ser Lys Lys Thr Ala Trp Ile Leu Gly Val Tyr 
705                 710                 715                 720 


Cys Arg Thr Tyr Ser Arg His Met Lys Tyr Val Val Arg Arg Cys Ala 
                725                 730                 735     


Asn Arg Gln Asn Leu Tyr Thr Lys Tyr Arg Pro Leu Phe Gly Tyr Trp 
            740                 745                 750         


Val Ile Gly Leu Gln Asn Lys Cys Lys Tyr Gly Val Phe Glu Glu Ser 
        755                 760                 765             


Leu Ser Ser Asp Pro Glu Val Leu Thr Leu Ser Met Ala Val Pro Pro 
    770                 775                 780                 


Cys Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Ile Val Ser Phe 
785                 790                 795                 800 


Phe Asn Val Thr Ser His Gly Ser Leu Ile Tyr Lys Phe Ser Lys Cys 
                805                 810                 815     


Cys Phe Ser Gln Pro Val Tyr Pro Tyr Phe Asn Pro Trp Asn Cys Pro 
            820                 825                 830         


Ala Pro Met Thr Leu Cys Pro Pro Ser Ser 
        835                 840         


<210> 5865
<211> 498
<212> PRT
<213> Homo sapiens

<400> 5865
Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu 
            20                  25                  30          


Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu 
        195                 200                 205             


Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly 
225                 230                 235                 240 


Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu 
                245                 250                 255     


Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser 
            260                 265                 270         


Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu 
        275                 280                 285             


Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala 
    290                 295                 300                 


Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Ala Pro 
                325                 330                 335     


Arg Ser Lys Arg Leu Leu Leu Pro Lys Asp Asn Asn Gly Met Ala Ala 
            340                 345                 350         


Leu Asn Gly Gly Leu Gly Ala Thr Gly Leu Thr Asn Gly Thr Ala Gly 
        355                 360                 365             


Thr Met Asp Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala 
    370                 375                 380                 


Ala Ala Ala Leu Pro Thr Leu Tyr Ser Gln Ser Leu Leu Gln Gln Gln 
385                 390                 395                 400 


Ser Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe 
                405                 410                 415     


Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln Asp Ile Leu Gln Met 
            420                 425                 430         


Phe Met Pro Phe Gly Asn Val Ile Ser Ala Lys Val Phe Ile Asp Lys 
        435                 440                 445             


Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro 
    450                 455                 460                 


Val Ser Ala Gln Ala Ala Ile Gln Ala Met Asn Gly Phe Gln Ile Gly 
465                 470                 475                 480 


Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys 
                485                 490                 495     


Pro Tyr 
        


<210> 5866
<211> 859
<212> PRT
<213> Homo sapiens

<400> 5866
Met Leu Glu Val Leu Glu Glu Ile Trp Ser Val Arg Ala Arg Arg Ala 
1               5                   10                  15      


His Arg Pro Cys Pro Gly Pro Ser Leu Ala Asp Asp Thr Asp Ala Asn 
            20                  25                  30          


Ser Asn Gly Ser Ser Gly Asn Glu Ser Asn Gly His Glu Ser Arg Gly 
        35                  40                  45              


Ala Ser Gln Arg Ser Ser His Ser Ser Ser Ser Gly Asn Gly Lys Asp 
    50                  55                  60                  


Ser Ala Leu Leu Glu Thr Thr Glu Ser Ser Lys Ser Thr Asn Ser Gln 
65                  70                  75                  80  


Ser Pro Ser Pro Pro Ser Ser Ser Ile Ala Tyr Ser Leu Leu Ser Ala 
                85                  90                  95      


Ser Ser Glu Gln Asp Asn Pro Ser Thr Ser Gly Cys Ser Ser Glu Gln 
            100                 105                 110         


Ser Ala Arg Ala Arg Thr Gln Lys Glu Leu Met Thr Ala Leu Arg Glu 
        115                 120                 125             


Leu Lys Leu Arg Leu Pro Pro Glu Arg Arg Gly Lys Gly Arg Ser Gly 
    130                 135                 140                 


Thr Leu Ala Thr Leu Gln Tyr Ala Leu Ala Cys Val Lys Gln Val Gln 
145                 150                 155                 160 


Ala Asn Gln Glu Tyr Tyr Gln Gln Trp Ser Leu Glu Glu Gly Glu Pro 
                165                 170                 175     


Cys Ser Met Asp Met Ser Thr Tyr Thr Leu Glu Glu Leu Glu His Ile 
            180                 185                 190         


Thr Ser Glu Tyr Thr Leu Gln Asn Gln Asp Thr Phe Ser Val Ala Val 
        195                 200                 205             


Ser Phe Leu Thr Gly Arg Ile Val Tyr Ile Ser Glu Gln Ala Ala Val 
    210                 215                 220                 


Leu Leu Arg Cys Lys Arg Asp Val Phe Arg Gly Thr Arg Phe Ser Glu 
225                 230                 235                 240 


Leu Leu Ala Pro Gln Asp Val Gly Val Phe Tyr Gly Ser Thr Ala Pro 
                245                 250                 255     


Ser Arg Leu Pro Thr Trp Gly Thr Gly Ala Ser Ala Gly Ser Gly Leu 
            260                 265                 270         


Arg Asp Phe Thr Gln Glu Lys Ser Val Phe Cys Arg Ile Arg Gly Gly 
        275                 280                 285             


Pro Asp Arg Asp Pro Gly Pro Arg Tyr Gln Pro Phe Arg Leu Thr Pro 
    290                 295                 300                 


Tyr Val Thr Lys Ile Arg Val Ser Asp Gly Ala Pro Ala Gln Pro Cys 
305                 310                 315                 320 


Cys Leu Leu Ile Ala Glu Arg Ile His Ser Gly Tyr Glu Ala Pro Arg 
                325                 330                 335     


Ile Pro Pro Asp Lys Arg Ile Phe Thr Thr Arg His Thr Pro Ser Cys 
            340                 345                 350         


Leu Phe Gln Asp Val Asp Glu Arg Ala Ala Pro Leu Leu Gly Tyr Leu 
        355                 360                 365             


Pro Gln Asp Leu Leu Gly Ala Pro Val Leu Leu Phe Leu His Pro Glu 
    370                 375                 380                 


Asp Arg Pro Leu Met Leu Ala Ile His Lys Lys Ile Leu Gln Leu Ala 
385                 390                 395                 400 


Gly Gln Pro Phe Asp His Ser Pro Ile Arg Phe Cys Ala Arg Asn Gly 
                405                 410                 415     


Glu Tyr Val Thr Met Asp Thr Ser Trp Ala Gly Phe Val His Pro Trp 
            420                 425                 430         


Ser Arg Lys Val Ala Phe Val Leu Gly Arg His Lys Val Arg Thr Ala 
        435                 440                 445             


Pro Leu Asn Glu Asp Val Phe Thr Pro Pro Ala Pro Ser Pro Ala Pro 
    450                 455                 460                 


Ser Leu Asp Thr Asp Ile Gln Glu Leu Ser Glu Gln Ile His Arg Leu 
465                 470                 475                 480 


Leu Leu Gln Pro Val His Ser Pro Ser Pro Thr Gly Leu Cys Gly Val 
                485                 490                 495     


Gly Ala Val Thr Ser Pro Gly Pro Leu His Ser Pro Gly Ser Ser Ser 
            500                 505                 510         


Asp Ser Asn Gly Gly Asp Ala Glu Gly Pro Gly Pro Pro Ala Pro Val 
        515                 520                 525             


Thr Phe Gln Gln Ile Cys Lys Asp Val His Leu Val Lys His Gln Gly 
    530                 535                 540                 


Gln Gln Leu Phe Ile Glu Ser Arg Ala Arg Pro Gln Ser Arg Pro Arg 
545                 550                 555                 560 


Leu Pro Ala Thr Gly Thr Phe Lys Ala Lys Ala Leu Pro Cys Gln Ser 
                565                 570                 575     


Pro Asp Pro Glu Leu Glu Ala Gly Ser Ala Pro Val Gln Ala Pro Leu 
            580                 585                 590         


Ala Leu Val Pro Glu Glu Ala Glu Arg Lys Glu Ala Ser Ser Cys Ser 
        595                 600                 605             


Tyr Gln Gln Ile Asn Cys Leu Asp Ser Ile Leu Arg Tyr Leu Glu Ser 
    610                 615                 620                 


Cys Asn Leu Pro Ser Thr Thr Lys Arg Lys Cys Ala Ser Ser Ser Ser 
625                 630                 635                 640 


Tyr Thr Thr Ser Ser Ala Ser Asp Asp Asp Arg Gln Arg Thr Gly Pro 
                645                 650                 655     


Val Ser Val Gly Thr Lys Lys Asp Pro Pro Ser Ala Ala Leu Ser Gly 
            660                 665                 670         


Glu Gly Ala Thr Pro Arg Lys Glu Pro Val Val Gly Gly Thr Leu Ser 
        675                 680                 685             


Pro Leu Ala Leu Ala Asn Lys Ala Glu Ser Val Val Ser Val Thr Ser 
    690                 695                 700                 


Gln Cys Ser Phe Ser Ser Thr Ile Val His Val Gly Asp Lys Lys Pro 
705                 710                 715                 720 


Pro Glu Ser Asp Ile Ile Met Met Glu Asp Leu Pro Gly Leu Ala Pro 
                725                 730                 735     


Gly Pro Ala Pro Ser Pro Ala Pro Ser Pro Thr Val Ala Pro Asp Pro 
            740                 745                 750         


Ala Pro Asp Ala Tyr Arg Pro Val Gly Leu Thr Lys Ala Val Leu Ser 
        755                 760                 765             


Leu His Thr Gln Lys Glu Glu Gln Ala Phe Leu Ser Arg Phe Arg Asp 
    770                 775                 780                 


Leu Gly Arg Leu Arg Gly Leu Asp Ser Ser Ser Thr Ala Pro Ser Ala 
785                 790                 795                 800 


Leu Gly Glu Arg Gly Ser His Leu Gly Pro Pro Gly Ala Cys Pro Leu 
                805                 810                 815     


Pro Ser Leu Gly Leu Asp Cys Trp Gly Val Gly Leu Lys Gly Gly Val 
            820                 825                 830         


Ser Ala Pro Gly Thr Gln Ala Gly Val Ala Ser Thr Thr Arg Pro Cys 
        835                 840                 845             


Leu Gly Thr Gly Pro Ser Leu Ala Ser Pro His 
    850                 855                 


<210> 5867
<211> 421
<212> PRT
<213> Homo sapiens

<400> 5867
Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg 
        115                 120                 125             


Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser 
    130                 135                 140                 


Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala 
145                 150                 155                 160 


Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys 
                165                 170                 175     


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
            180                 185                 190         


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
        195                 200                 205             


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
    210                 215                 220                 


Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu 
225                 230                 235                 240 


Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu 
                245                 250                 255     


Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe 
            260                 265                 270         


Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His 
        275                 280                 285             


Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu 
    290                 295                 300                 


Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala 
305                 310                 315                 320 


Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile 
                325                 330                 335     


His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp 
            340                 345                 350         


Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr 
        355                 360                 365             


Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys 
    370                 375                 380                 


Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile 
385                 390                 395                 400 


Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile 
                405                 410                 415     


Thr Asn Ile Phe Ala 
            420     


<210> 5868
<211> 676
<212> PRT
<213> Homo sapiens

<400> 5868
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe 
                85                  90                  95      


Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile 
            100                 105                 110         


Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu 
        115                 120                 125             


Asn Lys Phe Leu Leu Leu Thr Phe Ala Asp Leu Lys Lys Tyr His Phe 
    130                 135                 140                 


Tyr Tyr Trp Phe Cys Tyr Pro Ala Leu Cys Leu Pro Glu Ser Leu Pro 
145                 150                 155                 160 


Leu Ile Gln Gly Pro Val Gly Leu Asp Gln Arg Phe Ser Leu Lys Gln 
                165                 170                 175     


Ile Glu Ala Leu Glu Cys Ala Tyr Asp Asn Leu Cys Gln Thr Glu Gly 
            180                 185                 190         


Val Thr Ala Leu Pro Tyr Phe Leu Ile Lys Tyr Asp Glu Asn Met Val 
        195                 200                 205             


Leu Val Ser Leu Leu Lys His Tyr Ser Asp Phe Phe Gln Gly Gln Arg 
    210                 215                 220                 


Thr Lys Ile Thr Ile Gly Val Tyr Asp Pro Cys Asn Leu Ala Gln Tyr 
225                 230                 235                 240 


Pro Gly Trp Pro Leu Arg Asn Phe Leu Val Leu Ala Ala His Arg Trp 
                245                 250                 255     


Ser Ser Ser Phe Gln Ser Val Glu Val Val Cys Phe Arg Asp Arg Thr 
            260                 265                 270         


Met Gln Gly Ala Arg Asp Val Ala His Ser Ile Ile Phe Glu Val Lys 
        275                 280                 285             


Leu Pro Glu Met Ala Phe Ser Pro Asp Cys Pro Lys Ala Val Gly Trp 
    290                 295                 300                 


Glu Lys Asn Gln Lys Gly Gly Met Gly Pro Arg Met Val Asn Leu Ser 
305                 310                 315                 320 


Glu Cys Met Asp Pro Lys Arg Leu Ala Glu Ser Ser Val Asp Leu Asn 
                325                 330                 335     


Leu Lys Leu Met Cys Trp Arg Leu Val Pro Thr Leu Asp Leu Asp Lys 
            340                 345                 350         


Val Val Ser Val Lys Cys Leu Leu Leu Gly Ala Gly Thr Leu Gly Cys 
        355                 360                 365             


Asn Val Ala Arg Thr Leu Met Gly Trp Gly Val Arg His Ile Thr Phe 
    370                 375                 380                 


Val Asp Asn Ala Lys Ile Ser Tyr Ser Asn Pro Val Arg Gln Pro Leu 
385                 390                 395                 400 


Tyr Glu Phe Glu Asp Cys Leu Gly Gly Gly Lys Pro Lys Ala Leu Ala 
                405                 410                 415     


Ala Ala Asp Arg Leu Gln Lys Ile Phe Pro Gly Val Asn Ala Arg Gly 
            420                 425                 430         


Phe Asn Met Ser Ile Pro Met Pro Gly His Pro Val Asn Phe Ser Ser 
        435                 440                 445             


Val Thr Leu Glu Gln Ala Arg Arg Asp Val Glu Gln Leu Glu Gln Leu 
    450                 455                 460                 


Ile Glu Ser His Asp Val Val Phe Leu Leu Met Asp Thr Arg Glu Ser 
465                 470                 475                 480 


Arg Trp Leu Pro Ala Val Ile Ala Ala Ser Lys Arg Lys Leu Val Ile 
                485                 490                 495     


Asn Ala Ala Leu Gly Phe Asp Thr Phe Val Val Met Arg His Gly Leu 
            500                 505                 510         


Lys Lys Pro Lys Gln Gln Gly Ala Gly Asp Leu Cys Pro Asn His Pro 
        515                 520                 525             


Val Ala Ser Ala Asp Leu Leu Gly Ser Ser Leu Phe Ala Asn Ile Pro 
    530                 535                 540                 


Gly Tyr Lys Leu Gly Cys Tyr Phe Cys Asn Asp Val Val Ala Pro Gly 
545                 550                 555                 560 


Asp Ser Thr Arg Asp Arg Thr Leu Asp Gln Gln Cys Thr Val Ser Arg 
                565                 570                 575     


Pro Gly Leu Ala Val Ile Ala Gly Ala Leu Ala Val Glu Leu Met Val 
            580                 585                 590         


Ser Val Leu Gln His Pro Glu Gly Gly Tyr Ala Ile Ala Ser Ser Ser 
        595                 600                 605             


Asp Asp Arg Met Asn Glu Pro Pro Thr Ser Leu Gly Leu Val Pro His 
    610                 615                 620                 


Gln Val Leu Asp Gln Tyr Glu Arg Glu Gly Phe Asn Phe Leu Ala Lys 
625                 630                 635                 640 


Val Phe Asn Ser Ser His Ser Phe Leu Glu Asp Leu Thr Gly Leu Thr 
                645                 650                 655     


Leu Leu His Gln Glu Thr Gln Ala Ala Glu Ile Trp Asp Met Ser Asp 
            660                 665                 670         


Asp Glu Thr Ile 
        675     


<210> 5869
<211> 442
<212> PRT
<213> Homo sapiens

<400> 5869
Met Ala Ser Asp Gly Ala Ser Ala Leu Pro Gly Pro Asp Met Ser Met 
1               5                   10                  15      


Lys Pro Ser Ala Ala Pro Ser Pro Ser Pro Ala Leu Pro Phe Leu Pro 
            20                  25                  30          


Pro Thr Ser Asp Pro Pro Asp His Pro Pro Arg Glu Pro Pro Pro Gln 
        35                  40                  45              


Pro Ile Met Pro Ser Val Phe Ser Pro Asp Asn Pro Leu Met Leu Ser 
    50                  55                  60                  


Ala Phe Pro Ser Ser Leu Leu Val Thr Gly Asp Gly Gly Pro Cys Leu 
65                  70                  75                  80  


Ser Gly Ala Gly Ala Gly Lys Val Ile Val Lys Val Lys Thr Glu Gly 
                85                  90                  95      


Gly Ser Ala Glu Pro Ser Gln Thr Gln Asn Phe Ile Leu Thr Gln Thr 
            100                 105                 110         


Ala Leu Asn Ser Thr Ala Pro Gly Thr Pro Cys Gly Gly Leu Glu Gly 
        115                 120                 125             


Pro Ala Pro Pro Phe Val Thr Ala Ser Asn Val Lys Thr Ile Leu Pro 
    130                 135                 140                 


Ser Lys Ala Val Gly Val Ser Gln Glu Gly Pro Pro Gly Leu Pro Pro 
145                 150                 155                 160 


Gln Pro Pro Pro Pro Val Ala Gln Leu Val Pro Ile Val Pro Leu Glu 
                165                 170                 175     


Lys Ala Trp Pro Gly Pro His Gly Thr Thr Gly Glu Gly Gly Pro Val 
            180                 185                 190         


Ala Thr Leu Ser Lys Pro Ser Leu Gly Asp Arg Ser Lys Ile Ser Lys 
        195                 200                 205             


Asp Val Tyr Glu Asn Phe Arg Gln Trp Gln Arg Tyr Lys Ala Leu Ala 
    210                 215                 220                 


Arg Arg His Leu Ser Gln Ser Pro Asp Thr Glu Ala Val Lys Glu Tyr 
225                 230                 235                 240 


Val Asp Ile Met Glu Trp Leu Val Gly Thr His Leu Ala Thr Gly Glu 
                245                 250                 255     


Ser Asp Gly Lys Gln Glu Glu Glu Gly Gln Gln Gln Glu Glu Glu Gly 
            260                 265                 270         


Met Tyr Pro Asp Pro Gly Leu Leu Ser Tyr Ile Asn Glu Leu Cys Ser 
        275                 280                 285             


Gln Lys Val Phe Val Ser Lys Val Glu Ala Val Ile His Pro Gln Phe 
    290                 295                 300                 


Leu Ala Asp Leu Leu Ser Pro Glu Lys Gln Arg Asp Pro Leu Ala Leu 
305                 310                 315                 320 


Ile Glu Glu Leu Glu Gln Glu Glu Gly Leu Thr Leu Ala Gln Leu Val 
                325                 330                 335     


Gln Lys Arg Leu Met Ala Leu Glu Glu Glu Glu Asp Ala Glu Ala Pro 
            340                 345                 350         


Pro Ser Phe Ser Gly Ala Gln Leu Asp Ser Ser Pro Ser Gly Ser Val 
        355                 360                 365             


Glu Asp Glu Asp Gly Asp Gly Arg Leu Arg Pro Ser Pro Gly Leu Gln 
    370                 375                 380                 


Gly Ala Gly Gly Ala Ala Cys Leu Gly Lys Val Ser Ser Ser Gly Lys 
385                 390                 395                 400 


Arg Ala Arg Glu Val His Gly Gly Gln Glu Gln Ala Leu Asp Ser Pro 
                405                 410                 415     


Arg Gly Met His Arg Asp Gly Asn Thr Leu Pro Ser Pro Ser Ser Trp 
            420                 425                 430         


Asp Leu Pro Thr Asn Gly Glu Ser Gln Cys 
        435                 440         


<210> 5870
<211> 221
<212> PRT
<213> Homo sapiens

<400> 5870
Met Gln Val Gln Asp Asp Gly Val Asn Leu Ile Pro Phe Ala Lys Cys 
1               5                   10                  15      


Ser Arg Val Val Ser Arg Ser Pro Pro Pro Arg Leu Pro Ser Gln Ser 
            20                  25                  30          


Leu Arg Pro Met Pro Gln Arg Tyr Gly Asp Val Phe Trp Lys Asn Leu 
        35                  40                  45              


Asn Gln Arg Pro Thr Pro Thr Trp Leu Glu Glu Gln His Ile Pro Pro 
    50                  55                  60                  


Met Leu Leu Pro Pro Pro Glu Met Leu Trp Arg Arg Lys Lys Arg Arg 
65                  70                  75                  80  


Pro Cys Leu Glu Gly Met Gln Gln Gln Gly Leu Gly Gly Val Pro Ala 
                85                  90                  95      


Arg Val Arg Ala Val Thr Tyr His Leu Glu Asp Leu Arg Arg Arg Gln 
            100                 105                 110         


Ser Ile Ile Asn Glu Leu Lys Lys Ala Gln Trp Gly Ser Ser Gly Ala 
        115                 120                 125             


Ala Ser Glu Pro Val Val Leu Gly Glu Glu Gly Cys Gly Phe Pro Ser 
    130                 135                 140                 


Thr Asn Glu Tyr Pro Asp Leu Glu Glu Glu Arg Ala Thr Tyr Pro Gln 
145                 150                 155                 160 


Glu Glu Asp Arg Phe Leu Thr Pro Gly Arg Ala Gln Leu Leu Trp Ser 
                165                 170                 175     


Pro Trp Ser Pro Leu Asp Gln Glu Glu Ala Cys Ala Ser Arg Gln Leu 
            180                 185                 190         


His Ser Leu Ala Ser Phe Ser Thr Val Thr Ala Arg Arg Asn Pro Leu 
        195                 200                 205             


His Asn Pro Trp Gly Met Glu Leu Ala Ala Ser Glu Glu 
    210                 215                 220     


<210> 5871
<211> 159
<212> PRT
<213> Homo sapiens

<400> 5871
Met Gln Arg Val Gly Asn Thr Phe Ser Asn Glu Ser Arg Val Ala Ser 
1               5                   10                  15      


Arg Cys Pro Ser Val Gly Leu Ala Glu Arg Asn Arg Val Ala Thr Met 
            20                  25                  30          


Pro Val Arg Leu Leu Arg Asp Ser Pro Ala Ala Gln Glu Asp Asn Asp 
        35                  40                  45              


His Ala Arg Asp Gly Phe Gln Met Lys Leu Asp Ala His Gly Phe Ala 
    50                  55                  60                  


Pro Glu Glu Leu Val Val Gln Val Asp Gly Gln Trp Leu Met Val Thr 
65                  70                  75                  80  


Gly Gln Gln Gln Leu Asp Val Arg Asp Pro Glu Arg Val Ser Tyr Arg 
                85                  90                  95      


Met Ser Gln Lys Val His Arg Lys Met Leu Pro Ser Asn Leu Ser Pro 
            100                 105                 110         


Thr Ala Met Thr Cys Cys Leu Thr Pro Ser Gly Gln Leu Trp Val Arg 
        115                 120                 125             


Gly Gln Cys Val Ala Leu Ala Leu Pro Glu Ala Gln Thr Gly Pro Ser 
    130                 135                 140                 


Pro Arg Leu Gly Ser Leu Gly Ser Lys Ala Ser Asn Leu Thr Arg 
145                 150                 155                 


<210> 5872
<211> 593
<212> PRT
<213> Homo sapiens

<400> 5872
Met Glu Lys Leu Ser Ala Leu Gln Glu Gln Lys Gly Glu Leu Arg Lys 
1               5                   10                  15      


Arg Leu Ser Tyr Thr Thr His Lys Leu Glu Lys Leu Glu Thr Glu Phe 
            20                  25                  30          


Asp Ser Thr Arg His Tyr Leu Glu Ile Glu Leu Arg Arg Ala Gln Glu 
        35                  40                  45              


Glu Leu Glu Lys Val Thr Glu Lys Leu Arg Arg Ile Gln Ser Asn Tyr 
    50                  55                  60                  


Met Ala Leu Gln Arg Ile Asn Gln Glu Leu Glu Asp Lys Leu Tyr Arg 
65                  70                  75                  80  


Met Gly Gln His Tyr Glu Glu Glu Lys Arg Ala Leu Ser His Glu Ile 
                85                  90                  95      


Val Ala Leu Asn Ser His Leu Leu Glu Ala Lys Val Thr Ile Asp Lys 
            100                 105                 110         


Leu Ser Glu Asp Asn Glu Leu Tyr Arg Lys Asp Cys Asn Leu Ala Ala 
        115                 120                 125             


Gln Leu Leu Gln Cys Ser Gln Thr Tyr Gly Arg Val His Lys Val Ser 
    130                 135                 140                 


Glu Leu Pro Ser Asp Phe Gln Glu Arg Val Ser Leu His Met Glu Lys 
145                 150                 155                 160 


His Gly Cys Ser Leu Pro Ser Pro Leu Cys His Pro Ala Tyr Ala Asp 
                165                 170                 175     


Ser Val Pro Thr Cys Val Ile Ala Lys Val Leu Glu Lys Pro Asp Pro 
            180                 185                 190         


Ala Ser Leu Ser Ser Arg Leu Ser Asp Ala Ser Ala Arg Asp Leu Ala 
        195                 200                 205             


Phe Cys Asp Gly Val Glu Lys Pro Gly Pro Arg Pro Pro Tyr Lys Gly 
    210                 215                 220                 


Asp Ile Tyr Cys Ser Asp Thr Ala Leu Tyr Cys Pro Glu Glu Arg Arg 
225                 230                 235                 240 


Arg Asp Arg Arg Pro Ser Val Asp Ala Pro Val Thr Asp Val Gly Phe 
                245                 250                 255     


Leu Arg Ala Gln Asn Ser Thr Asp Ser Ala Ala Glu Glu Glu Glu Glu 
            260                 265                 270         


Ala Glu Ala Ala Ala Phe Pro Ala Gly Phe Gln His Glu Ala Phe Pro 
        275                 280                 285             


Ser Tyr Ala Gly Ser Leu Pro Thr Ser Ser Ser Tyr Ser Ser Phe Ser 
    290                 295                 300                 


Ala Thr Ser Glu Glu Lys Glu His Ala Gln Ala Ser Thr Leu Thr Ala 
305                 310                 315                 320 


Ser Gln Gln Ala Ile Tyr Leu Asn Ser Arg Asp Glu Leu Phe Asp Arg 
                325                 330                 335     


Lys Pro Pro Ala Thr Thr Tyr Glu Gly Ser Pro Arg Phe Ala Lys Ala 
            340                 345                 350         


Thr Ala Ala Val Ala Ala Pro Leu Glu Ala Glu Val Ala Pro Gly Phe 
        355                 360                 365             


Gly Arg Thr Met Ser Pro Tyr Pro Ala Glu Thr Phe Arg Phe Pro Ala 
    370                 375                 380                 


Ser Pro Gly Pro Gln Gln Ala Leu Met Pro Pro Asn Leu Trp Ser Leu 
385                 390                 395                 400 


Arg Ala Lys Pro Gly Thr Ala Arg Leu Pro Gly Glu Asp Met Arg Gly 
                405                 410                 415     


Gln Trp Arg Pro Leu Ser Val Glu Asp Ile Gly Ala Tyr Ser Tyr Pro 
            420                 425                 430         


Val Ser Ala Ala Gly Arg Ala Ser Pro Cys Ser Phe Ser Glu Arg Tyr 
        435                 440                 445             


Tyr Gly Gly Ala Gly Gly Ser Pro Gly Lys Lys Ala Asp Gly Arg Ala 
    450                 455                 460                 


Ser Pro Leu Tyr Ala Ser Tyr Lys Ala Asp Ser Phe Ser Glu Gly Asp 
465                 470                 475                 480 


Asp Leu Ser Gln Gly His Leu Ala Glu Pro Cys Phe Leu Arg Ala Gly 
                485                 490                 495     


Gly Asp Leu Ser Leu Ser Pro Gly Arg Ser Ala Asp Pro Leu Pro Gly 
            500                 505                 510         


Tyr Ala Pro Ser Glu Gly Gly Asp Gly Asp Arg Leu Gly Val Gln Leu 
        515                 520                 525             


Cys Gly Thr Ala Ser Ser Pro Glu Pro Glu Gln Gly Ser Arg Asp Ser 
    530                 535                 540                 


Leu Glu Pro Ser Ser Met Glu Ala Ser Pro Glu Met His Pro Ala Ala 
545                 550                 555                 560 


Arg Leu Ser Pro Gln Gln Ala Phe Pro Arg Thr Gly Gly Ser Gly Leu 
                565                 570                 575     


Ser Arg Lys Asp Ser Leu Thr Lys Ala Gln Leu Tyr Gly Thr Leu Leu 
            580                 585                 590         


Asn 
    


<210> 5873
<211> 869
<212> PRT
<213> Homo sapiens

<400> 5873
Met Gly Asn Arg Glu Met Glu Glu Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Leu Gly Gln Ser Cys Leu Leu Glu Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Thr Ser Lys Ala Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Asp Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Met Asn 
            100                 105                 110         


Lys Gly Ile Ser Ser Ile Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Glu Met Ile 
145                 150                 155                 160 


Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val Thr Pro 
                165                 170                 175     


Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu His Glu Val Glu Ala Tyr Lys Asn Phe Lys Pro Glu 
305                 310                 315                 320 


Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
            340                 345                 350         


Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Ile Val Lys Lys Gln 
                405                 410                 415     


Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu Val Ile 
            420                 425                 430         


Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Lys Leu Ala Asn 
        435                 440                 445             


Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Thr Thr Val 
            500                 505                 510         


Gly Asn Gln Gly Thr Asn Leu Pro Pro Ser Arg Gln Ile Val Ile Arg 
        515                 520                 525             


Lys Gly Trp Leu Thr Ile Ser Asn Ile Gly Ile Met Lys Gly Gly Ser 
    530                 535                 540                 


Lys Gly Tyr Trp Phe Val Leu Thr Ala Glu Ser Leu Ser Trp Tyr Lys 
545                 550                 555                 560 


Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met Leu Pro Leu Asp Asn Leu 
                565                 570                 575     


Lys Val Arg Asp Val Glu Lys Ser Phe Met Ser Ser Lys His Ile Phe 
            580                 585                 590         


Ala Leu Phe Asn Thr Glu Gln Arg Asn Val Tyr Lys Asp Tyr Arg Phe 
        595                 600                 605             


Leu Glu Leu Ala Cys Asp Ser Gln Glu Asp Val Asp Ser Trp Lys Ala 
    610                 615                 620                 


Ser Leu Leu Arg Ala Gly Val Tyr Pro Asp Lys Ser Val Ala Glu Asn 
625                 630                 635                 640 


Asp Glu Asn Gly Gln Ala Glu Asn Phe Ser Met Asp Pro Gln Leu Glu 
                645                 650                 655     


Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser Tyr Met Ser Ile 
            660                 665                 670         


Ile Asn Lys Cys Ile Arg Asp Leu Ile Pro Lys Thr Ile Met His Leu 
        675                 680                 685             


Met Ile Asn Asn Val Lys Asp Phe Ile Asn Ser Glu Leu Leu Ala Gln 
    690                 695                 700                 


Leu Tyr Ser Ser Glu Asp Gln Asn Thr Leu Met Glu Glu Ser Ala Glu 
705                 710                 715                 720 


Gln Ala Gln Arg Arg Asp Glu Met Leu Arg Met Tyr Gln Ala Leu Lys 
                725                 730                 735     


Glu Ala Leu Gly Ile Ile Gly Asp Ile Ser Thr Ala Thr Val Ser Thr 
            740                 745                 750         


Pro Ala Pro Pro Pro Val Asp Asp Ser Trp Ile Gln His Ser Arg Arg 
        755                 760                 765             


Ser Pro Pro Pro Ser Pro Thr Thr Gln Arg Arg Pro Thr Leu Ser Ala 
    770                 775                 780                 


Pro Leu Ala Arg Pro Thr Ser Gly Arg Gly Pro Ala Pro Ala Ile Pro 
785                 790                 795                 800 


Ser Pro Gly Pro His Ser Gly Ala Pro Pro Val Pro Phe Arg Pro Gly 
                805                 810                 815     


Pro Leu Pro Pro Phe Pro Ser Ser Ser Asp Ser Phe Gly Ala Pro Pro 
            820                 825                 830         


Gln Val Pro Ser Arg Pro Thr Arg Ala Pro Pro Ser Val Pro Ser Arg 
        835                 840                 845             


Arg Pro Pro Pro Ser Pro Thr Arg Pro Thr Ile Ile Arg Pro Leu Glu 
    850                 855                 860                 


Ser Ser Leu Leu Asp 
865                 


<210> 5874
<211> 631
<212> PRT
<213> Homo sapiens

<400> 5874
Met Asn Ser Ser Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu 
1               5                   10                  15      


Lys Glu Gln Ala Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln 
            20                  25                  30          


Lys Thr Lys Glu Lys Cys Asp Lys Ile Arg Gln Glu Arg Asp Glu Ala 
        35                  40                  45              


Val Lys Lys Leu Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu 
    50                  55                  60                  


Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg 
65                  70                  75                  80  


Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr 
                85                  90                  95      


Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val 
            100                 105                 110         


Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr 
        115                 120                 125             


Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile 
    130                 135                 140                 


Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Lys Leu Val Glu Val Ile 
                165                 170                 175     


Glu Glu Val Asn Lys Val Lys Gln Glu Lys Thr Val Leu Asn Ser Glu 
            180                 185                 190         


Val Leu Glu Gln Arg Lys Val Leu Glu Lys Cys Asn Arg Val Ser Met 
        195                 200                 205             


Leu Ala Val Glu Glu Tyr Glu Glu Met Gln Val Asn Leu Glu Leu Glu 
    210                 215                 220                 


Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala Gln Glu Met Phe Ile 
225                 230                 235                 240 


Glu Gln Asn Lys Leu Lys Arg Gln Ser His Leu Leu Leu Gln Ser Ser 
                245                 250                 255     


Ile Pro Asp Gln Gln Leu Leu Lys Ala Leu Asp Glu Asn Ala Lys Leu 
            260                 265                 270         


Thr Gln Gln Leu Glu Glu Glu Arg Ile Gln His Gln Gln Lys Val Lys 
        275                 280                 285             


Glu Leu Glu Glu Gln Leu Glu Asn Glu Thr Leu His Lys Glu Ile His 
    290                 295                 300                 


Asn Leu Lys Gln Gln Leu Glu Leu Leu Glu Glu Asp Lys Lys Glu Leu 
305                 310                 315                 320 


Glu Leu Lys Tyr Gln Asn Ser Glu Glu Lys Ala Arg Asn Leu Lys His 
                325                 330                 335     


Ser Val Asp Glu Leu Gln Lys Arg Val Asn Gln Ser Glu Asn Ser Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Asn 
        355                 360                 365             


Pro Ile Arg Ser Leu Met Ser Met Ile Arg Lys Arg Ser His Pro Ser 
    370                 375                 380                 


Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gln Pro Glu Thr Thr Glu 
385                 390                 395                 400 


Glu Val Thr Asp Leu Lys Arg Gln Ala Val Glu Glu Met Met Asp Arg 
                405                 410                 415     


Ile Lys Lys Gly Val His Leu Arg Pro Val Asn Gln Thr Ala Arg Pro 
            420                 425                 430         


Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser Ala Val Asp Glu 
        435                 440                 445             


Leu Lys Gly Ile Leu Gly Thr Leu Asn Lys Ser Thr Ser Ser Arg Ser 
    450                 455                 460                 


Leu Lys Ser Leu Asp Pro Glu Asn Ser Glu Thr Glu Leu Glu Arg Ile 
465                 470                 475                 480 


Leu Arg Arg Arg Lys Val Thr Ala Glu Ala Asp Ser Ser Ser Pro Thr 
                485                 490                 495     


Gly Ile Leu Ala Thr Ser Glu Ser Lys Ser Met Pro Val Leu Gly Ser 
            500                 505                 510         


Val Ser Ser Val Thr Lys Thr Ala Leu Asn Lys Lys Thr Leu Glu Ala 
        515                 520                 525             


Glu Phe Asn Ser Pro Ser Pro Pro Thr Pro Glu Pro Gly Glu Gly Pro 
    530                 535                 540                 


Arg Lys Leu Glu Gly Cys Thr Ser Ser Lys Val Thr Phe Gln Pro Pro 
545                 550                 555                 560 


Ser Ser Ile Gly Cys Arg Lys Lys Tyr Ile Asp Gly Glu Lys Gln Ala 
                565                 570                 575     


Glu Pro Val Val Val Leu Asp Pro Val Ser Thr His Glu Pro Gln Thr 
            580                 585                 590         


Lys Asp Gln Val Ala Glu Lys Asp Pro Thr Gln His Lys Glu Asp Glu 
        595                 600                 605             


Gly Glu Ile Gln Pro Glu Asn Lys Glu Asp Ser Ile Glu Asn Val Arg 
    610                 615                 620                 


Glu Thr Asp Ser Ser Asn Cys 
625                 630     


<210> 5875
<211> 566
<212> PRT
<213> Homo sapiens

<400> 5875
Met Asp Leu His Arg Ala Ala Phe Lys Met Glu Asn Ser Ser Tyr Leu 
1               5                   10                  15      


Pro Asn Pro Leu Ala Ser Pro Ala Leu Met Val Leu Ala Ser Thr Ala 
            20                  25                  30          


Glu Ala Ser Arg Asp Ala Ser Ile Pro Cys Gln Gln Pro Arg Pro Phe 
        35                  40                  45              


Gly Val Pro Val Ser Val Asp Lys Asp Val His Ile Pro Phe Thr Asn 
    50                  55                  60                  


Gly Ser Tyr Thr Phe Ala Ser Met Tyr His Arg Gln Gly Gly Val Pro 
65                  70                  75                  80  


Gly Thr Phe Ala Asn Arg Asp Phe Pro Pro Ser Leu Leu His Leu His 
                85                  90                  95      


Pro Gln Phe Ala Pro Pro Asn Leu Asp Cys Thr Pro Ile Ser Met Leu 
            100                 105                 110         


Asn His Ser Gly Val Gly Ala Phe Arg Pro Phe Ala Ser Thr Glu Asp 
        115                 120                 125             


Arg Glu Ser Tyr Gln Ser Ala Phe Thr Pro Ala Lys Arg Leu Lys Asn 
    130                 135                 140                 


Cys His Asp Thr Glu Ser Pro His Leu Arg Phe Ser Asp Ala Asp Gly 
145                 150                 155                 160 


Lys Glu Tyr Asp Phe Gly Thr Gln Leu Pro Ser Ser Ser Pro Gly Ser 
                165                 170                 175     


Leu Lys Val Asp Asp Thr Gly Lys Lys Ile Phe Ala Val Ser Gly Leu 
            180                 185                 190         


Ile Ser Asp Arg Glu Ala Ser Ser Ser Pro Glu Asp Arg Asn Asp Arg 
        195                 200                 205             


Cys Lys Lys Lys Ala Ala Ala Leu Phe Asp Ser Gln Ala Pro Ile Cys 
    210                 215                 220                 


Pro Ile Cys Gln Val Leu Leu Arg Pro Ser Glu Leu Gln Glu His Met 
225                 230                 235                 240 


Glu Gln Glu Leu Glu Gln Leu Ala Gln Leu Pro Ser Ser Lys Asn Ser 
                245                 250                 255     


Leu Leu Lys Asp Ala Met Ala Pro Gly Thr Pro Lys Ser Leu Leu Leu 
            260                 265                 270         


Ser Ala Ser Ile Lys Arg Glu Gly Glu Ser Pro Thr Ala Ser Pro His 
        275                 280                 285             


Ser Ser Ala Thr Asp Asp Leu His His Ser Asp Arg Tyr Gln Thr Phe 
    290                 295                 300                 


Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn Ala Arg Ile Gly 
305                 310                 315                 320 


Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Arg Glu Gly Ser Cys 
                325                 330                 335     


Met Ala Glu Asp Asp Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg 
            340                 345                 350         


Phe Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr 
        355                 360                 365             


Leu Leu Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly 
    370                 375                 380                 


Lys Glu Asn Pro Asp Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp 
385                 390                 395                 400 


Thr Leu Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro 
                405                 410                 415     


Cys Thr Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg 
            420                 425                 430         


Gly Ala Val Leu Asn Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu 
        435                 440                 445             


Phe Ser Lys Trp Ala Ser Asp Glu Met Pro Ser Thr Ser Asn Gly Glu 
    450                 455                 460                 


Ser Ser Lys Gln Glu Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile 
465                 470                 475                 480 


Glu Lys Ile Thr Glu Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys 
                485                 490                 495     


Ala Arg Val Arg Glu Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr 
            500                 505                 510         


Lys Cys Leu Ile Cys Met Asp Ser Tyr Ser Met Pro Leu Thr Ser Ile 
        515                 520                 525             


Gln Cys Trp His Val His Cys Glu Glu Cys Trp Leu Arg Thr Leu Gly 
    530                 535                 540                 


Ala Lys Lys Leu Cys Pro Gln Cys Asn Thr Ile Thr Ala Pro Gly Asp 
545                 550                 555                 560 


Leu Arg Arg Ile Tyr Leu 
                565     


<210> 5876
<211> 356
<212> PRT
<213> Homo sapiens

<400> 5876
Met Leu Ser Ala Ile Thr Asn Val Val Gln Asn Thr Gly Lys Ser Val 
1               5                   10                  15      


Leu Thr Gly Gly Leu Asp Ala Leu Glu Phe Ile Gly Lys Lys Thr Met 
            20                  25                  30          


Asn Val Leu Ala Glu Ser Asp Pro Gly Phe Lys Arg Thr Lys Thr Leu 
        35                  40                  45              


Met Glu Arg Thr Val Ser Leu Ser Gln Met Leu Arg Glu Ala Lys Glu 
    50                  55                  60                  


Lys Glu Lys Gln Arg Leu Ala Gln Gln Leu Thr Met Glu Arg Thr Ala 
65                  70                  75                  80  


His Tyr Gly Met Leu Phe Asp Glu Tyr Gln Gly Leu Ser His Leu Glu 
                85                  90                  95      


Ala Leu Glu Ile Leu Ser Asn Glu Ser Glu Ser Lys Val Gln Ser Phe 
            100                 105                 110         


Leu Ala Ser Leu Asp Gly Glu Lys Leu Glu Leu Leu Lys Asn Asp Leu 
        115                 120                 125             


Ile Ser Ile Lys Asp Ile Phe Ala Ala Lys Glu Leu Glu Asn Glu Glu 
    130                 135                 140                 


Asn Gln Glu Glu Gln Gly Leu Glu Glu Lys Gly Glu Glu Phe Ala Arg 
145                 150                 155                 160 


Met Leu Thr Glu Leu Leu Phe Glu Leu His Val Ala Ala Thr Pro Asp 
                165                 170                 175     


Lys Leu Asn Lys Ala Met Lys Arg Ala His Asp Trp Val Glu Glu Asp 
            180                 185                 190         


Gln Thr Val Val Ser Val Asp Val Ala Lys Val Ser Glu Glu Glu Thr 
        195                 200                 205             


Lys Lys Glu Glu Lys Glu Glu Lys Ser Gln Asp Pro Gln Glu Asp Lys 
    210                 215                 220                 


Lys Glu Glu Lys Lys Thr Lys Thr Ile Glu Glu Val Tyr Met Ser Ser 
225                 230                 235                 240 


Ile Glu Ser Leu Ala Glu Val Thr Ala Arg Cys Ile Glu Gln Leu His 
                245                 250                 255     


Lys Val Ala Glu Leu Ile Leu His Gly Gln Glu Glu Glu Lys Pro Ala 
            260                 265                 270         


Gln Asp Gln Ala Lys Val Leu Ile Lys Leu Thr Thr Ala Met Cys Asn 
        275                 280                 285             


Glu Val Ala Ser Leu Ser Lys Lys Phe Thr Asn Ser Leu Thr Thr Val 
    290                 295                 300                 


Gly Ser Asn Lys Lys Ala Glu Val Leu Asn Pro Met Ile Ser Ser Val 
305                 310                 315                 320 


Leu Leu Glu Gly Cys Asn Ser Thr Thr Tyr Ile Gln Asp Ala Phe Gln 
                325                 330                 335     


Leu Leu Leu Pro Val Leu Gln Val Ser His Ile Gln Thr Ser Cys Leu 
            340                 345                 350         


Lys Ala Gln Pro 
        355     


<210> 5877
<211> 172
<212> PRT
<213> Homo sapiens

<400> 5877
Met Ser Tyr Asn Cys Cys Ser Gly Asn Phe Ser Ser Arg Ser Cys Gly 
1               5                   10                  15      


Gly Tyr Leu His Tyr Pro Ala Ser Ser Cys Gly Phe Ser Tyr Pro Ser 
            20                  25                  30          


Asn Gln Val Tyr Ser Thr Asp Leu Cys Ser Pro Ser Thr Cys Gln Leu 
        35                  40                  45              


Gly Ser Ser Leu Tyr Arg Gly Cys Gln Gln Thr Cys Trp Glu Pro Thr 
    50                  55                  60                  


Ser Cys Gln Thr Ser Tyr Val Glu Ser Ser Pro Cys Gln Thr Ser Cys 
65                  70                  75                  80  


Tyr Arg Pro Arg Thr Ser Leu Leu Cys Ser Pro Cys Gln Thr Thr Tyr 
                85                  90                  95      


Ser Gly Ser Leu Gly Phe Gly Ser Ser Ser Cys Arg Ser Leu Gly Tyr 
            100                 105                 110         


Gly Ser Arg Ser Cys Tyr Ser Val Gly Cys Gly Ser Ser Gly Phe Arg 
        115                 120                 125             


Ser Leu Gly Tyr Gly Gly Cys Gly Phe Pro Ser Leu Gly Tyr Gly Val 
    130                 135                 140                 


Gly Phe Cys Arg Pro Thr Tyr Leu Ala Ser Arg Ser Cys Gln Ser Ser 
145                 150                 155                 160 


Cys Tyr Arg Pro Thr Cys Gly Ser Gly Phe Tyr Tyr 
                165                 170         


<210> 5878
<211> 750
<212> PRT
<213> Homo sapiens

<400> 5878
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala 
    130                 135                 140                 


Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr 
145                 150                 155                 160 


Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp 
                165                 170                 175     


Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys 
            180                 185                 190         


Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys Gln Val Ala Trp Ile 
        195                 200                 205             


Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu Leu Leu Pro Val Cys 
    210                 215                 220                 


Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala 
225                 230                 235                 240 


Glu Asp Asn Leu Leu Ala Leu Gly Leu Lys His Phe Glu Gly Thr Glu 
                245                 250                 255     


Phe Leu Asn Pro Leu Ile Ser Lys Tyr Leu Leu Thr Cys Lys Thr Ala 
            260                 265                 270         


Arg Gln Leu Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala Pro 
        275                 280                 285             


Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu 
    290                 295                 300                 


Gly Lys Cys Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro Ile 
305                 310                 315                 320 


Glu Arg Glu Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro 
                325                 330                 335     


Ser Ile Gln Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu Val 
            340                 345                 350         


Gly Asn Met Thr Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu Glu 
        355                 360                 365             


Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu Leu 
    370                 375                 380                 


Pro Lys Gly Val Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe Pro 
385                 390                 395                 400 


Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu Leu 
                405                 410                 415     


Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys Thr 
            420                 425                 430         


Pro Ala Gln Ser Thr His Ser Glu Ala Pro Pro Ser Lys Met Val Leu 
        435                 440                 445             


Arg Ile Pro His Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val Pro 
    450                 455                 460                 


Gly Val Pro Pro Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser Pro 
465                 470                 475                 480 


Ala Ala Leu Pro Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro Leu 
                485                 490                 495     


Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val Met 
            500                 505                 510         


Met Pro Ser Pro Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg Arg 
        515                 520                 525             


Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys Pro 
    530                 535                 540                 


Ala Pro Val Ile His Pro Ala Ser Val Ile Phe Thr Val Pro Ala Thr 
545                 550                 555                 560 


Thr Val Lys Ile Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln Pro 
                565                 570                 575     


Val Asn Ala Ala Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala Thr 
            580                 585                 590         


Leu Leu Val Asn Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro Leu 
        595                 600                 605             


Val Ala Ser Ser Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val Asn 
    610                 615                 620                 


Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys Ala His Met Asn Val Asp 
625                 630                 635                 640 


Ile Ala Cys Ala Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu Glu 
                645                 650                 655     


Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val Phe 
            660                 665                 670         


Pro Lys Val Glu His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln Cys 
        675                 680                 685             


Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val Lys 
    690                 695                 700                 


Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile Gln 
705                 710                 715                 720 


Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val Lys 
                725                 730                 735     


Met Glu Pro Glu Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
            740                 745                 750 


<210> 5879
<211> 295
<212> PRT
<213> Homo sapiens

<400> 5879
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 5880
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5880
Met Asp Thr Lys Gly Cys Thr Thr Thr Asn Ser Pro Ser Thr Pro Cys 
1               5                   10                  15      


Gln Asn Cys Ser Arg Ile Thr Asn Val Ser Thr Ile Ser Ser Asn Asn 
            20                  25                  30          


Gly Cys His Pro Gly Gly Leu Thr Val Asn Asn Cys Gln Pro Ala Gly 
        35                  40                  45              


His Val Leu Arg Ile Pro Trp Asp Gln Gly Cys Gln Pro Thr Pro Arg 
    50                  55                  60                  


Phe Cys Arg Lys Pro Ile Tyr Leu Met Asn Asn Phe Asn Ala Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Asp Cys Ser Trp Tyr Gly Glu Gly Ile Asn Ser Asn Glu 
                85                  90                  95      


Lys Glu Thr Met Gln Ile Leu Asn Glu Arg Leu Ala Asn Tyr Leu Gln 
            100                 105                 110         


Lys Val Arg Met Leu Glu Arg Glu Asn Ala Glu Leu Glu Ser Lys Ile 
        115                 120                 125             


Gln Glu Glu Ser Asn Lys Glu Leu Pro Val Leu Cys Pro Asp Tyr Leu 
    130                 135                 140                 


Ser Tyr Tyr Thr Thr Ile Glu Glu Leu Gln Gln Lys Ile Leu Cys Thr 
145                 150                 155                 160 


Lys Ala Glu Asn Ser Arg Leu Val Ser Gln Ile Asp Asn Thr Lys Leu 
                165                 170                 175     


Thr Ala Asp Asp Leu Arg Ala Lys Tyr Glu Ala Glu Val Ser Leu Arg 
            180                 185                 190         


Gln Leu Val Glu Ser Asp Ala Asn Gly Leu Lys Gln Ile Leu Asn Val 
        195                 200                 205             


Leu Thr Leu Gly Lys Ala Asp Leu Glu Ala Gln Val Gln Ser Leu Lys 
    210                 215                 220                 


Glu Glu Leu Leu Cys Leu Lys Asn Asn His Lys Glu Glu Ile Asn Ser 
225                 230                 235                 240 


Leu Gln Cys Gln Leu Gly Glu Arg Leu Asp Ile Glu Val Thr Ala Ala 
                245                 250                 255     


Pro Ser Ala Asp Leu Asn Gln Val Leu Gln Glu Met Arg Cys Gln Tyr 
            260                 265                 270         


Glu Pro Ile Met Glu Thr Asn Arg Lys Asp Val Glu Gln Trp Phe Asn 
        275                 280                 285             


Thr Gln Ile Glu Glu Leu Asn Gln Gln Val Val Thr Ser Ser Gln Gln 
    290                 295                 300                 


Gln Gln Cys Cys Gln Lys Glu Ile Ile Glu Leu Arg Arg Ser Val Asn 
305                 310                 315                 320 


Thr Leu Glu Val Glu Leu Gln Ala Gln His Arg Met Arg Asp Ser Gln 
                325                 330                 335     


Glu Cys Ile Leu Thr Glu Thr Glu Ala Arg Tyr Thr Ala Leu Leu Thr 
            340                 345                 350         


Gln Ile Gln Ser Leu Ile Asp Asn Leu Glu Ala Gln Leu Ala Glu Ile 
        355                 360                 365             


Arg Cys Ala Leu Glu Arg Gln Asn Gln Glu Tyr Glu Ile Leu Leu Asp 
    370                 375                 380                 


Val Lys Ser Arg Leu Glu Cys Glu Ile Thr Thr Tyr Arg Ser Leu Leu 
385                 390                 395                 400 


Glu Ser Ser Asp Gly Lys Arg Pro Cys Tyr Pro Arg Ala Thr Lys Cys 
                405                 410                 415     


Glu Pro Ser Pro Trp Thr Ser Cys Lys Ser Gly Ala Ile Glu Ser Thr 
            420                 425                 430         


Ala Pro Ala Cys Thr Ser Ser Ser Pro Cys Ser Leu Lys Glu His Cys 
        435                 440                 445             


Ser Ala Cys Gly Pro Leu Ser Arg Ile Leu Val Lys Ile Cys Thr Ile 
    450                 455                 460                 


Thr Lys Glu Ile Lys Asp Gly Lys Val Ile Ser Ser Tyr Glu His Val 
465                 470                 475                 480 


Gln Pro Cys Phe Ile Ile Arg Pro Ala Lys Val 
                485                 490     


<210> 5881
<211> 428
<212> PRT
<213> Homo sapiens

<400> 5881
Met Lys Arg Gly Gly Arg Asp Ser Asp Arg Asn Ser Ser Glu Glu Gly 
1               5                   10                  15      


Thr Ala Glu Lys Ser Lys Lys Leu Arg Thr Thr Asn Glu His Ser Gln 
            20                  25                  30          


Thr Cys Asp Trp Gly Asn Leu Leu Gln Asp Ile Ile Leu Gln Val Phe 
        35                  40                  45              


Lys Tyr Leu Pro Leu Leu Asp Arg Ala His Ala Ser Gln Val Cys Arg 
    50                  55                  60                  


Asn Trp Asn Gln Val Phe His Met Pro Asp Leu Trp Arg Cys Phe Glu 
65                  70                  75                  80  


Phe Glu Leu Asn Gln Pro Ala Thr Ser Tyr Leu Lys Ala Thr His Pro 
                85                  90                  95      


Glu Leu Ile Lys Gln Ile Ile Lys Arg His Ser Asn His Leu Gln Tyr 
            100                 105                 110         


Val Ser Phe Lys Val Asp Ser Ser Lys Glu Ser Ala Glu Ala Ala Cys 
        115                 120                 125             


Asp Ile Leu Ser Gln Leu Val Asn Cys Ser Leu Lys Thr Leu Gly Leu 
    130                 135                 140                 


Ile Ser Thr Ala Arg Pro Ser Phe Met Asp Leu Pro Lys Ser His Phe 
145                 150                 155                 160 


Ile Ser Ala Leu Thr Val Val Phe Val Asn Ser Lys Ser Leu Ser Ser 
                165                 170                 175     


Leu Lys Ile Asp Asp Thr Pro Val Asp Asp Pro Ser Leu Lys Val Leu 
            180                 185                 190         


Val Ala Asn Asn Ser Asp Thr Leu Lys Leu Leu Lys Met Ser Ser Cys 
        195                 200                 205             


Pro His Val Ser Pro Ala Gly Ile Leu Cys Val Ala Asp Gln Cys His 
    210                 215                 220                 


Gly Leu Arg Glu Leu Ala Leu Asn Tyr His Leu Leu Ser Asp Glu Leu 
225                 230                 235                 240 


Leu Leu Ala Leu Ser Ser Glu Lys His Val Arg Leu Glu His Leu Arg 
                245                 250                 255     


Ile Asp Val Val Ser Glu Asn Pro Gly Gln Thr His Phe His Thr Ile 
            260                 265                 270         


Gln Lys Ser Ser Trp Asp Ala Phe Ile Arg His Ser Pro Lys Val Asn 
        275                 280                 285             


Leu Val Met Tyr Phe Phe Leu Tyr Glu Glu Glu Phe Asp Pro Phe Phe 
    290                 295                 300                 


Arg Tyr Glu Ile Pro Ala Thr His Leu Tyr Phe Gly Arg Ser Val Ser 
305                 310                 315                 320 


Lys Asp Val Leu Gly Arg Val Gly Met Thr Cys Pro Arg Leu Val Glu 
                325                 330                 335     


Leu Val Val Cys Ala Asn Gly Leu Arg Pro Leu Asp Glu Glu Leu Ile 
            340                 345                 350         


Arg Ile Ala Glu Arg Cys Lys Asn Leu Ser Ala Ile Gly Leu Gly Glu 
        355                 360                 365             


Cys Glu Val Ser Cys Ser Ala Phe Val Glu Phe Val Lys Met Cys Gly 
    370                 375                 380                 


Gly Arg Leu Ser Gln Leu Ser Ile Met Glu Glu Val Leu Ile Pro Asp 
385                 390                 395                 400 


Gln Lys Tyr Ser Leu Glu Gln Ile His Trp Glu Val Ser Lys His Leu 
                405                 410                 415     


Gly Arg Val Trp Phe Pro Asp Met Met Pro Thr Trp 
            420                 425             


<210> 5882
<211> 1200
<212> PRT
<213> Homo sapiens

<400> 5882
Met Asn Thr Asp Ser Gly Gly Cys Ala Arg Lys Arg Ala Ala Met Ser 
1               5                   10                  15      


Val Thr Leu Thr Ser Val Lys Arg Val Gln Ser Ser Pro Asn Leu Leu 
            20                  25                  30          


Ala Ala Gly Arg Asp Ser Gln Ser Pro Asp Ser Ala Trp Arg Ser Tyr 
        35                  40                  45              


Asn Asp Gly Asn Gln Glu Thr Leu Asn Gly Asp Ala Thr Tyr Ser Ser 
    50                  55                  60                  


Leu Ala Ala Lys Gly Phe Arg Ser Val Arg Pro Asn Leu Gln Asp Lys 
65                  70                  75                  80  


Arg Ser Pro Thr Gln Ser Gln Ile Thr Val Asn Gly Asn Ser Gly Gly 
                85                  90                  95      


Ala Val Ser Pro Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala 
            100                 105                 110         


Tyr Ser Leu Pro Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly 
        115                 120                 125             


Thr Ser Leu Asp Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu 
    130                 135                 140                 


Asp Gly Thr Thr Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu 
145                 150                 155                 160 


Glu Lys Arg Val Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly 
                165                 170                 175     


Pro Val Asp Glu Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp 
            180                 185                 190         


Arg Pro Lys Asp Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val 
        195                 200                 205             


His Lys Pro Asp Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr 
    210                 215                 220                 


Asn Ala Gly Leu Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala 
225                 230                 235                 240 


Ala Lys Thr Gln Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn 
                245                 250                 255     


Ser Pro Asn Ala Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His 
            260                 265                 270         


Val Pro Pro Pro Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr 
        275                 280                 285             


Glu Lys His Asp Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys 
    290                 295                 300                 


Phe Arg Ser Glu Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser 
305                 310                 315                 320 


Ser Ile Leu Gln His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile 
                325                 330                 335     


Asp Arg Ser Leu Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp 
            340                 345                 350         


Phe Arg Lys Arg Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly 
        355                 360                 365             


Leu Gly Asp Gln Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu 
    370                 375                 380                 


Pro Gly Ser Ser Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro 
385                 390                 395                 400 


Ser Ser Pro Ser Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro 
                405                 410                 415     


Ser Leu Cys Ser Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu 
            420                 425                 430         


Asp Tyr Cys Ser Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser 
        435                 440                 445             


Pro Arg Ala Ile Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn 
    450                 455                 460                 


Ala Glu Ile Trp Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys 
465                 470                 475                 480 


Ser Arg Ser Cys Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro 
                485                 490                 495     


Asp Pro Lys Val Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu 
            500                 505                 510         


Asp Ser Lys Glu Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro 
        515                 520                 525             


Glu Val Arg Ser Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg 
    530                 535                 540                 


Asn Ala Pro Gly Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn 
545                 550                 555                 560 


Arg Lys Asp Leu Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg 
                565                 570                 575     


Ile Leu Gln Tyr Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala 
            580                 585                 590         


Trp Ser Gln Cys Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr 
        595                 600                 605             


Arg Ile Ser Glu Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro 
    610                 615                 620                 


Asn Leu Gly Asp Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln 
625                 630                 635                 640 


Asn Gly Leu Cys Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu 
                645                 650                 655     


Glu Glu Asn Gln Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln 
            660                 665                 670         


Ser Asn Ala Leu Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln 
        675                 680                 685             


Pro Arg Ala His Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val 
    690                 695                 700                 


Ser Asp His Ser Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser 
705                 710                 715                 720 


Glu Ser Asp Phe Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr 
                725                 730                 735     


Gly Ser Ser His His His His His His His His His His His Arg His 
            740                 745                 750         


Leu Ile Ser Ser Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe 
        755                 760                 765             


Thr Thr Met Leu Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu 
    770                 775                 780                 


Pro Arg Arg Gln Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu 
785                 790                 795                 800 


Val Ser Pro Val Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys 
                805                 810                 815     


Gln Thr Glu Lys Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp 
            820                 825                 830         


Ser Ala Leu Lys Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg 
        835                 840                 845             


Gly Ser Leu Pro Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu 
    850                 855                 860                 


Leu Pro Asp Val Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg 
865                 870                 875                 880 


Ser Pro Leu His Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile 
                885                 890                 895     


His Cys Pro Pro Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala 
            900                 905                 910         


Ser Phe Gln Asp Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp 
        915                 920                 925             


Arg Gly Gly Ala Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser 
    930                 935                 940                 


Thr Leu Thr Asp Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr 
945                 950                 955                 960 


Pro Glu Lys Glu Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala 
                965                 970                 975     


Gln Thr Ser Lys Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile 
            980                 985                 990         


Leu Arg Lys Ile Asp Gln Asn Trp  Tyr Glu Gly Glu His  His Gly Arg 
        995                 1000                 1005             


Val Gly  Ile Phe Pro Ile Ser  Tyr Val Glu Lys Leu  Thr Pro Pro 
    1010                 1015                 1020             


Glu Lys  Ala Gln Pro Ala Arg  Pro Pro Pro Pro Ala  Gln Pro Gly 
    1025                 1030                 1035             


Glu Ile  Gly Glu Ala Ile Ala  Lys Tyr Asn Phe Asn  Ala Asp Thr 
    1040                 1045                 1050             


Asn Val  Glu Leu Ser Leu Arg  Lys Gly Asp Arg Val  Ile Leu Leu 
    1055                 1060                 1065             


Lys Arg  Val Asp Gln Asn Trp  Tyr Glu Gly Lys Ile  Pro Gly Thr 
    1070                 1075                 1080             


Asn Arg  Gln Gly Ile Phe Pro  Val Ser Tyr Val Glu  Val Val Lys 
    1085                 1090                 1095             


Lys Asn  Thr Lys Gly Ala Glu  Asp Tyr Pro Asp Pro  Pro Ile Pro 
    1100                 1105                 1110             


His Ser  Tyr Ser Ser Asp Arg  Ile His Ser Leu Ser  Ser Asn Lys 
    1115                 1120                 1125             


Pro Gln  Arg Pro Val Phe Thr  His Glu Asn Ile Gln  Gly Gly Gly 
    1130                 1135                 1140             


Glu Pro  Phe Gln Ala Leu Tyr  Asn Tyr Thr Pro Arg  Asn Glu Asp 
    1145                 1150                 1155             


Glu Leu  Glu Leu Arg Glu Ser  Asp Val Ile Asp Val  Met Glu Lys 
    1160                 1165                 1170             


Cys Asp  Asp Gly Trp Phe Val  Gly Thr Ser Arg Arg  Thr Lys Phe 
    1175                 1180                 1185             


Phe Gly  Thr Phe Pro Gly Asn  Tyr Val Lys Arg Leu  
    1190                 1195                 1200 


<210> 5883
<211> 489
<212> PRT
<213> Homo sapiens

<400> 5883
Met Glu Asp Ser Ala Ser Ala Ser Leu Ser Ser Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr Ser Thr Ser Thr Pro Ala Ala Pro Thr Ala Arg Lys Gln Leu Asp 
            20                  25                  30          


Lys Glu Gln Val Arg Lys Ala Val Asp Ala Leu Leu Thr His Cys Lys 
        35                  40                  45              


Ser Arg Lys Asn Asn Tyr Gly Leu Leu Leu Asn Glu Asn Glu Ser Leu 
    50                  55                  60                  


Phe Leu Met Val Val Leu Trp Lys Ile Pro Ser Lys Glu Leu Arg Val 
65                  70                  75                  80  


Arg Leu Thr Leu Pro His Ser Ile Arg Ser Asp Ser Glu Asp Ile Cys 
                85                  90                  95      


Leu Phe Thr Lys Asp Glu Pro Asn Ser Thr Pro Glu Lys Thr Glu Gln 
            100                 105                 110         


Phe Tyr Arg Lys Leu Leu Asn Lys His Gly Ile Lys Thr Val Ser Gln 
        115                 120                 125             


Ile Ile Ser Leu Gln Thr Leu Lys Lys Glu Tyr Lys Ser Tyr Glu Ala 
    130                 135                 140                 


Lys Leu Arg Leu Leu Ser Ser Phe Asp Phe Phe Leu Thr Asp Ala Arg 
145                 150                 155                 160 


Ile Arg Arg Leu Leu Pro Ser Leu Ile Gly Arg His Phe Tyr Gln Arg 
                165                 170                 175     


Lys Lys Val Pro Val Ser Val Asn Leu Leu Ser Lys Asn Leu Ser Arg 
            180                 185                 190         


Glu Ile Asn Asp Cys Ile Gly Gly Thr Val Leu Asn Ile Ser Lys Ser 
        195                 200                 205             


Gly Ser Cys Ser Ala Ile Arg Ile Gly His Val Gly Met Gln Ile Glu 
    210                 215                 220                 


His Ile Ile Glu Asn Ile Val Ala Val Thr Lys Gly Leu Ser Glu Lys 
225                 230                 235                 240 


Leu Pro Glu Trp Glu Ser Val Lys Leu Leu Phe Val Lys Thr Glu Lys 
                245                 250                 255     


Ser Ala Ala Leu Pro Ile Phe Ser Ser Phe Val Ser Asn Trp Asp Glu 
            260                 265                 270         


Ala Thr Lys Arg Ser Leu Leu Asn Lys Lys Lys Lys Glu Ala Arg Arg 
        275                 280                 285             


Lys Arg Arg Glu Arg Asn Phe Glu Lys Gln Lys Glu Arg Lys Lys Lys 
    290                 295                 300                 


Arg Gln Gln Ala Arg Lys Thr Ala Ser Val Leu Ser Lys Asp Asp Val 
305                 310                 315                 320 


Ala Pro Glu Ser Gly Asp Thr Thr Val Lys Lys Pro Glu Ser Lys Lys 
                325                 330                 335     


Glu Gln Thr Pro Glu His Gly Lys Lys Lys Arg Gly Arg Gly Lys Ala 
            340                 345                 350         


Gln Val Lys Ala Thr Asn Glu Ser Glu Asp Glu Ile Pro Gln Leu Val 
        355                 360                 365             


Pro Ile Gly Lys Lys Thr Pro Ala Asn Glu Lys Val Glu Ile Gln Lys 
    370                 375                 380                 


His Ala Thr Gly Lys Lys Ser Pro Ala Lys Ser Pro Asn Pro Ser Thr 
385                 390                 395                 400 


Pro Arg Gly Lys Lys Arg Lys Ala Leu Pro Ala Ser Glu Thr Pro Lys 
                405                 410                 415     


Ala Ala Glu Ser Glu Thr Pro Gly Lys Ser Pro Glu Lys Lys Pro Lys 
            420                 425                 430         


Ile Lys Glu Glu Ala Val Lys Glu Lys Ser Pro Ser Leu Gly Lys Lys 
        435                 440                 445             


Asp Ala Arg Gln Thr Pro Lys Lys Pro Glu Ala Lys Phe Phe Thr Thr 
    450                 455                 460                 


Pro Ser Lys Ser Val Arg Lys Ala Ser His Thr Pro Lys Lys Trp Pro 
465                 470                 475                 480 


Lys Lys Pro Lys Val Pro Gln Ser Thr 
                485                 


<210> 5884
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 5884
Met Ala Gly Ala Leu Arg Arg Gly Arg Ala Leu Gly Ser Arg Pro Ser 
1               5                   10                  15      


Gly Pro Thr Val Ser Ser Arg Arg Ser Pro Gln Cys Pro Val Ala Gln 
            20                  25                  30          


Glu Gly Leu Gly Ala Arg Ser Arg Pro Arg Val Ala Pro Arg Ser Leu 
        35                  40                  45              


Ala Arg Cys Gly Pro Ser Ser Arg Leu Met Gly Trp Lys Pro Ser Glu 
    50                  55                  60                  


Ala Arg Gly Gln Ser Gln Ser Phe Gln Ala Ser Gly Leu Gln Pro Arg 
65                  70                  75                  80  


Ser Leu Lys Ala Ala Arg Arg Ala Thr Gly Arg Pro Asp Arg Ser Arg 
                85                  90                  95      


Ala Ala Pro Pro Asn Met Asp Pro Asp Pro Gln Ala Gly Val Gln Val 
            100                 105                 110         


Gly Met Arg Val Val Arg Gly Val Asp Trp Lys Trp Gly Gln Gln Asp 
        115                 120                 125             


Gly Gly Glu Gly Gly Val Gly Thr Val Val Glu Leu Gly Arg His Gly 
    130                 135                 140                 


Ser Pro Ser Thr Pro Asp Arg Thr Val Val Val Gln Trp Asp Gln Gly 
145                 150                 155                 160 


Thr Arg Thr Asn Tyr Arg Ala Gly Tyr Gln Gly Ala His Asp Leu Leu 
                165                 170                 175     


Leu Tyr Asp Asn Ala Gln Ile Gly Val Arg His Pro Asn Ile Ile Cys 
            180                 185                 190         


Asp Cys Cys Lys Lys His Gly Leu Arg Gly Met Arg Trp Lys Cys Arg 
        195                 200                 205             


Val Cys Leu Asp Tyr Asp Leu Cys Thr Gln Cys Tyr Met His Asn Lys 
    210                 215                 220                 


His Glu Leu Ala His Ala Phe Asp Arg Tyr Glu Thr Ala His Ser Arg 
225                 230                 235                 240 


Pro Val Thr Leu Ser Pro Arg Gln Gly Leu Pro Arg Ile Pro Leu Arg 
                245                 250                 255     


Gly Ile Phe Gln Gly Ala Lys Val Val Arg Gly Pro Asp Trp Glu Trp 
            260                 265                 270         


Gly Ser Gln Asp Gly Gly Glu Gly Lys Pro Gly Arg Val Val Asp Ile 
        275                 280                 285             


Arg Gly Trp Asp Val Glu Thr Gly Arg Ser Val Ala Ser Val Thr Trp 
    290                 295                 300                 


Ala Asp Gly Thr Thr Asn Val Tyr Arg Val Gly His Lys Gly Lys Val 
305                 310                 315                 320 


Asp Leu Lys Cys Val Gly Glu Ala Ala Gly Gly Phe Tyr Tyr Lys Asp 
                325                 330                 335     


His Leu Pro Arg Leu Gly Lys Pro Ala Glu Leu Gln Arg Arg Val Ser 
            340                 345                 350         


Ala Asp Ser Gln Pro Phe Gln His Gly Asp Lys Val Lys Cys Leu Leu 
        355                 360                 365             


Asp Thr Asp Val Leu Arg Glu Met Gln Glu Gly His Gly Gly Trp Asn 
    370                 375                 380                 


Pro Arg Met Ala Glu Phe Ile Gly Gln Thr Gly Thr Val His Arg Ile 
385                 390                 395                 400 


Thr Asp Arg Gly Asp Val Arg Val Gln Phe Asn His Glu Thr Arg Trp 
                405                 410                 415     


Thr Phe His Pro Gly Ala Leu Thr Lys His His Ser Phe Trp Val Gly 
            420                 425                 430         


Asp Val Val Arg Val Ile Gly Asp Leu Asp Thr Val Lys Arg Leu Gln 
        435                 440                 445             


Ala Gly His Gly Glu Trp Thr Asp Asp Met Ala Pro Ala Leu Gly Arg 
    450                 455                 460                 


Val Gly Lys Val Val Lys Val Phe Gly Asp Gly Asn Leu Arg Val Ala 
465                 470                 475                 480 


Val Ala Gly Gln Arg Trp Thr Phe Ser Pro Ser Cys Leu Val Ala Tyr 
                485                 490                 495     


Arg Pro Glu Glu Asp Ala Asn Leu Asp Val Ala Glu Arg Ala Arg Glu 
            500                 505                 510         


Asn Lys Ser Ser Leu Ser Val Ala Leu Asp Lys Leu Arg Ala Gln Lys 
        515                 520                 525             


Ser Asp Pro Glu His Pro Gly Arg Leu Val Val Glu Val Ala Leu Gly 
    530                 535                 540                 


Asn Ala Ala Arg Ala Leu Asp Leu Leu Arg Arg Arg Pro Glu Gln Val 
545                 550                 555                 560 


Asp Thr Lys Asn Gln Gly Arg Thr Ala Leu Gln Val Ala Ala Tyr Leu 
                565                 570                 575     


Gly Gln Val Glu Leu Ile Arg Leu Leu Leu Gln Ala Arg Ala Gly Val 
            580                 585                 590         


Asp Leu Pro Asp Asp Glu Gly Asn Thr Ala Leu His Tyr Ala Ala Leu 
        595                 600                 605             


Gly Asn Gln Pro Glu Ala Thr Arg Val Leu Leu Ser Ala Gly Cys Arg 
    610                 615                 620                 


Ala Asp Ala Ile Asn Ser Thr Gln Ser Thr Ala Leu His Val Ala Val 
625                 630                 635                 640 


Gln Arg Gly Phe Leu Glu Val Val Arg Ala Leu Cys Glu Arg Gly Cys 
                645                 650                 655     


Asp Val Asn Leu Pro Asp Ala His Ser Asp Thr Pro Leu His Ser Ala 
            660                 665                 670         


Ile Ser Ala Gly Thr Gly Ala Ser Gly Ile Val Glu Val Leu Thr Glu 
        675                 680                 685             


Val Pro Asn Ile Asp Val Thr Ala Thr Asn Ser Gln Gly Phe Thr Leu 
    690                 695                 700                 


Leu His His Ala Ser Leu Lys Gly His Ala Leu Ala Val Arg Lys Ile 
705                 710                 715                 720 


Leu Ala Arg Ala Arg Gln Leu Val Asp Ala Lys Lys Glu Asp Gly Phe 
                725                 730                 735     


Thr Ala Leu His Leu Ala Ala Leu Asn Asn His Arg Glu Val Ala Gln 
            740                 745                 750         


Ile Leu Ile Arg Glu Gly Arg Cys Asp Val Asn Val Arg Asn Arg Lys 
        755                 760                 765             


Leu Gln Ser Pro Leu His Leu Ala Val Gln Gln Ala His Val Gly Leu 
    770                 775                 780                 


Val Pro Leu Leu Val Asp Ala Gly Cys Ser Val Asn Ala Glu Asp Glu 
785                 790                 795                 800 


Glu Gly Asp Thr Ala Leu His Val Ala Leu Gln Arg His Gln Leu Leu 
                805                 810                 815     


Pro Leu Val Ala Asp Gly Ala Gly Gly Asp Pro Gly Pro Leu Gln Leu 
            820                 825                 830         


Leu Ser Arg Leu Gln Ala Ser Gly Leu Pro Gly Ser Ala Glu Leu Thr 
        835                 840                 845             


Val Gly Ala Ala Val Ala Cys Phe Leu Ala Leu Glu Gly Ala Asp Val 
    850                 855                 860                 


Ser Tyr Thr Asn His Arg Gly Arg Ser Pro Leu Asp Leu Ala Ala Glu 
865                 870                 875                 880 


Gly Arg Val Leu Lys Ala Leu Gln Gly Cys Ala Gln Arg Phe Arg Glu 
                885                 890                 895     


Arg Gln Ala Gly Gly Gly Ala Ala Pro Gly Pro Arg Gln Thr Leu Gly 
            900                 905                 910         


Thr Pro Asn Thr Val Thr Asn Leu His Val Gly Ala Ala Pro Gly Pro 
        915                 920                 925             


Glu Ala Ala Glu Cys Leu Val Cys Ser Glu Leu Ala Leu Leu Val Leu 
    930                 935                 940                 


Phe Ser Pro Cys Gln His Arg Thr Val Cys Glu Glu Cys Ala Arg Arg 
945                 950                 955                 960 


Met Lys Lys Cys Ile Arg Cys Gln Val Val Val Ser Lys Lys Leu Arg 
                965                 970                 975     


Pro Asp Gly Ser Glu Val Ala Ser Ala Ala Pro Ala Pro Gly Pro Pro 
            980                 985                 990         


Arg Gln Leu Val Glu Glu Leu Gln  Ser Arg Tyr Arg Gln  Met Glu Glu 
        995                 1000                 1005             


Arg Ile  Thr Cys Pro Ile Cys  Ile Asp Ser His Ile  Arg Leu Val 
    1010                 1015                 1020             


Phe Gln  Cys Gly His Gly Ala  Cys Ala Pro Cys Gly  Ser Ala Leu 
    1025                 1030                 1035             


Ser Ala  Cys Pro Ile Cys Arg  Gln Pro Ile Arg Asp  Arg Ile Gln 
    1040                 1045                 1050             


Ile Phe  Val 
    1055     


<210> 5885
<211> 285
<212> PRT
<213> Homo sapiens

<400> 5885
Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro 
        35                  40                  45              


Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys 
    50                  55                  60                  


Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp 
65                  70                  75                  80  


Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val 
                85                  90                  95      


Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly 
            100                 105                 110         


Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu 
        115                 120                 125             


Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Gly Ser Thr Asn Tyr Gly Lys Ser 
            260                 265                 270         


Gln Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
        275                 280                 285 


<210> 5886
<211> 403
<212> PRT
<213> Homo sapiens

<400> 5886
Met Ser Gly Ser Asp Gly Gly Leu Glu Glu Glu Pro Glu Leu Ser Ile 
1               5                   10                  15      


Thr Leu Thr Leu Arg Met Leu Met His Gly Lys Glu Val Gly Ser Ile 
            20                  25                  30          


Ile Gly Lys Lys Gly Glu Thr Val Lys Arg Ile Arg Glu Gln Ser Ser 
        35                  40                  45              


Ala Arg Ile Thr Ile Ser Glu Gly Ser Cys Pro Glu Arg Ile Thr Thr 
    50                  55                  60                  


Ile Thr Gly Ser Thr Ala Ala Val Phe His Ala Val Ser Met Ile Ala 
65                  70                  75                  80  


Phe Lys Leu Asp Glu Asp Leu Cys Ala Ala Pro Ala Asn Gly Gly Asn 
                85                  90                  95      


Val Ser Arg Pro Pro Val Thr Leu Arg Leu Val Ile Pro Ala Ser Gln 
            100                 105                 110         


Cys Gly Ser Leu Ile Gly Lys Ala Gly Thr Lys Ile Lys Glu Ile Arg 
        115                 120                 125             


Glu Thr Thr Gly Ala Gln Val Gln Val Ala Gly Asp Leu Leu Pro Asn 
    130                 135                 140                 


Ser Thr Glu Arg Ala Val Thr Val Ser Gly Val Pro Asp Ala Ile Ile 
145                 150                 155                 160 


Leu Cys Val Arg Gln Ile Cys Ala Val Ile Leu Glu Ser Pro Pro Lys 
                165                 170                 175     


Gly Ala Thr Ile Pro Tyr His Pro Ser Leu Ser Leu Gly Thr Val Leu 
            180                 185                 190         


Leu Ser Ala Asn Gln Gly Phe Ser Val Gln Gly Gln Tyr Gly Ala Val 
        195                 200                 205             


Thr Pro Ala Glu Val Thr Lys Leu Gln Gln Leu Ser Ser His Ala Val 
    210                 215                 220                 


Pro Phe Ala Thr Pro Ser Val Val Pro Gly Leu Asp Pro Gly Thr Gln 
225                 230                 235                 240 


Thr Ser Ser Gln Glu Phe Leu Val Pro Asn Asp Leu Ile Gly Cys Val 
                245                 250                 255     


Ile Gly Arg Gln Gly Ser Lys Ile Ser Glu Ile Arg Gln Met Ser Gly 
            260                 265                 270         


Ala His Ile Lys Ile Gly Asn Gln Ala Glu Gly Ala Gly Glu Arg His 
        275                 280                 285             


Val Thr Ile Thr Gly Ser Pro Val Ser Ile Ala Leu Ala Gln Tyr Leu 
    290                 295                 300                 


Ile Thr Ala Cys Leu Glu Thr Ala Lys Ser Thr Ser Gly Gly Thr Pro 
305                 310                 315                 320 


Ser Ser Ala Pro Ala Asp Leu Pro Ala Pro Phe Ser Pro Pro Leu Thr 
                325                 330                 335     


Ala Leu Pro Thr Ala Pro Pro Gly Leu Leu Gly Thr Pro Tyr Ala Ile 
            340                 345                 350         


Ser Leu Ser Asn Phe Ile Gly Leu Lys Pro Met Pro Phe Leu Ala Leu 
        355                 360                 365             


Pro Pro Ala Ser Pro Gly Pro Pro Pro Gly Leu Ala Ala Tyr Thr Ala 
    370                 375                 380                 


Lys Met Ala Ala Ala Asn Gly Ser Lys Lys Ala Glu Arg Gln Lys Phe 
385                 390                 395                 400 


Ser Pro Tyr 
            


<210> 5887
<211> 448
<212> PRT
<213> Homo sapiens

<400> 5887
Met Ala Thr Asp Ser Trp Ala Leu Ala Val Asp Glu Gln Glu Ala Ala 
1               5                   10                  15      


Ala Glu Ser Leu Ser Asn Leu His Leu Lys Glu Glu Lys Ile Lys Pro 
            20                  25                  30          


Asp Thr Asn Gly Ala Val Val Lys Thr Asn Ala Asn Ala Glu Lys Thr 
        35                  40                  45              


Asp Glu Glu Glu Lys Glu Asp Arg Ala Ala Gln Ser Leu Leu Asn Lys 
    50                  55                  60                  


Leu Ile Arg Ser Asn Leu Val Asp Asn Thr Asn Gln Val Glu Val Leu 
65                  70                  75                  80  


Gln Arg Asp Pro Asn Ser Pro Leu Tyr Ser Val Lys Ser Phe Glu Glu 
                85                  90                  95      


Leu Arg Leu Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly Thr Gly 
            100                 105                 110         


Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Gln Val Glu Pro Ala 
        115                 120                 125             


Asn Lys Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr Tyr Glu Leu Ala 
    130                 135                 140                 


Leu Gln Thr Gly Lys Val Ile Glu Gln Met Gly Lys Phe Tyr Pro Glu 
145                 150                 155                 160 


Leu Lys Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu Glu Arg Gly Gln 
                165                 170                 175     


Lys Ile Ser Glu Gln Ile Val Ile Gly Thr Pro Gly Thr Val Leu Asp 
            180                 185                 190         


Trp Cys Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys Ile Lys Val Phe 
        195                 200                 205             


Val Leu Asp Glu Ala Asp Val Met Ile Ala Thr Gln Gly His Gln Asp 
    210                 215                 220                 


Gln Ser Ile Arg Ile Gln Arg Met Leu Pro Arg Asn Cys Gln Met Leu 
225                 230                 235                 240 


Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Lys Phe Ala Gln Lys 
                245                 250                 255     


Val Val Pro Asp Pro Asn Val Ile Lys Leu Lys Arg Glu Glu Glu Thr 
            260                 265                 270         


Leu Asp Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser Ser Arg Asp Glu 
        275                 280                 285             


Lys Phe Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile Thr Ile Ala Gln 
    290                 295                 300                 


Ala Met Ile Phe Cys His Thr Arg Lys Thr Ala Ser Trp Leu Ala Ala 
305                 310                 315                 320 


Glu Leu Ser Lys Glu Gly His Gln Val Ala Leu Leu Ser Gly Glu Met 
                325                 330                 335     


Met Val Glu Gln Arg Ala Ala Val Ile Glu Arg Phe Arg Glu Gly Lys 
            340                 345                 350         


Glu Lys Val Leu Val Thr Thr Asn Val Cys Ala Arg Gly Ile Asp Val 
        355                 360                 365             


Glu Gln Val Ser Val Val Ile Asn Phe Asp Leu Pro Val Asp Lys Asp 
    370                 375                 380                 


Gly Asn Pro Asp Asn Glu Thr Tyr Leu His Arg Ile Gly Arg Thr Gly 
385                 390                 395                 400 


Arg Phe Gly Lys Arg Gly Leu Ala Val Asn Met Val Asp Ser Lys His 
                405                 410                 415     


Ser Met Asn Ile Leu Asn Arg Ile Gln Glu His Phe Asn Lys Lys Ile 
            420                 425                 430         


Glu Arg Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu Lys Ile Ala Asn 
        435                 440                 445             


<210> 5888
<211> 415
<212> PRT
<213> Homo sapiens

<400> 5888
Met Met Leu Gly Pro Glu Gly Gly Glu Gly Phe Val Val Lys Leu Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Val Glu Asp Val Gln Asn Phe Leu Ser 
            20                  25                  30          


Asp Cys Thr Ile His Asp Gly Ala Ala Gly Val His Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Gln Ser Gly Glu Ala Phe Val Glu Leu Gly Ser Glu 
    50                  55                  60                  


Asp Asp Val Lys Met Ala Leu Lys Lys Asp Arg Glu Ser Met Gly His 
65                  70                  75                  80  


Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu Glu Val Arg 
            180                 185                 190         


Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly Ile Val Lys 
    210                 215                 220                 


Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser Thr Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr Gly Phe Thr 
                245                 250                 255     


Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser Gly Met Tyr 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr Gly Ala Ser 
        355                 360                 365             


Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly Val Ser Ala 
    370                 375                 380                 


Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val Ser Gly Cys 
385                 390                 395                 400 


Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly Tyr Asp 
                405                 410                 415 


<210> 5889
<211> 341
<212> PRT
<213> Homo sapiens

<400> 5889
Met Ala Gln Glu Ser Pro Lys Asn Ser Ala Ala Glu Ile Pro Val Thr 
1               5                   10                  15      


Ser Asn Gly Glu Val Asp Asp Ser Arg Glu His Ser Phe Asn Arg Asp 
            20                  25                  30          


Leu Lys His Ser Leu Pro Ser Gly Leu Gly Leu Ser Glu Thr Gln Ile 
        35                  40                  45              


Thr Ser His Gly Phe Asp Asn Thr Lys Glu Gly Val Ile Glu Ala Gly 
    50                  55                  60                  


Ala Phe Gln Gly Gly Gln Arg Thr Gln Thr Lys Ser Gly Pro Val Ile 
65                  70                  75                  80  


Leu Ala Asp Glu Ile Lys Asn Pro Ala Met Glu Lys Leu Glu Leu Val 
                85                  90                  95      


Arg Lys Trp Ser Leu Asn Thr Tyr Lys Cys Thr Arg Gln Ile Ile Ser 
            100                 105                 110         


Glu Lys Leu Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Ala 
        115                 120                 125             


Gln Ile Asp Ile Leu Arg Asp Asn Lys Lys Lys Tyr Glu Asn Ile Leu 
    130                 135                 140                 


Lys Leu Ala Gln Thr Leu Ser Thr Gln Leu Phe Gln Met Val His Thr 
145                 150                 155                 160 


Gln Arg Gln Leu Gly Asp Ala Phe Ala Asp Leu Ser Leu Lys Ser Leu 
                165                 170                 175     


Glu Leu His Glu Glu Phe Gly Tyr Asn Ala Asp Thr Gln Lys Leu Leu 
            180                 185                 190         


Ala Lys Asn Gly Glu Thr Leu Leu Gly Ala Ile Asn Phe Phe Ile Ala 
        195                 200                 205             


Ser Val Asn Thr Leu Val Asn Lys Thr Ile Glu Asp Thr Leu Met Thr 
    210                 215                 220                 


Val Lys Gln Tyr Glu Ser Ala Arg Ile Glu Tyr Asp Ala Tyr Arg Thr 
225                 230                 235                 240 


Asp Leu Glu Glu Leu Asn Leu Gly Pro Arg Asp Ala Asn Thr Leu Pro 
                245                 250                 255     


Lys Ile Glu Gln Ser Gln His Leu Phe Gln Ala His Lys Glu Lys Tyr 
            260                 265                 270         


Asp Lys Met Arg Asn Asp Val Ser Val Lys Leu Lys Phe Leu Glu Glu 
        275                 280                 285             


Asn Lys Val Lys Val Leu His Asn Gln Leu Val Leu Phe His Asn Ala 
    290                 295                 300                 


Ile Ala Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
305                 310                 315                 320 


Lys Gln Phe His Ile Lys Leu Lys Thr Pro Gly Val Asp Ala Pro Ser 
                325                 330                 335     


Trp Leu Glu Glu Gln 
            340     


<210> 5890
<211> 523
<212> PRT
<213> Homo sapiens

<400> 5890
Met Ala Asn Val Gly Leu Gln Phe Gln Ala Ser Ala Gly Asp Ser Asp 
1               5                   10                  15      


Pro Gln Ser Arg Pro Leu Leu Leu Leu Gly Gln Leu His His Leu His 
            20                  25                  30          


Arg Val Pro Trp Ser His Val Arg Gly Lys Leu Gln Pro Arg Val Thr 
        35                  40                  45              


Glu Glu Leu Trp Gln Ala Ala Leu Ser Thr Leu Asn Pro Asn Pro Thr 
    50                  55                  60                  


Asp Ser Cys Pro Leu Tyr Leu Asn Tyr Ala Thr Val Ala Ala Leu Pro 
65                  70                  75                  80  


Cys Arg Val Ser Arg His Asn Ser Pro Ser Ala Ala His Phe Ile Thr 
                85                  90                  95      


Arg Leu Val Arg Thr Cys Leu Pro Pro Gly Ala His Arg Cys Ile Val 
            100                 105                 110         


Met Val Cys Glu Gln Pro Glu Val Phe Ala Ser Ala Cys Ala Leu Ala 
        115                 120                 125             


Arg Ala Phe Pro Leu Phe Thr His Arg Ser Gly Ala Ser Arg Arg Leu 
    130                 135                 140                 


Glu Lys Lys Thr Val Thr Val Glu Phe Phe Leu Val Gly Gln Asp Asn 
145                 150                 155                 160 


Gly Pro Val Glu Val Ser Thr Leu Gln Cys Leu Ala Asn Ala Thr Asp 
                165                 170                 175     


Gly Val Arg Leu Ala Ala Arg Ile Val Asp Thr Pro Cys Asn Glu Met 
            180                 185                 190         


Asn Thr Asp Thr Phe Leu Glu Glu Ile Asn Lys Val Gly Lys Glu Leu 
        195                 200                 205             


Gly Ile Ile Pro Thr Ile Ile Arg Asp Glu Glu Leu Lys Thr Arg Gly 
    210                 215                 220                 


Phe Gly Gly Ile Tyr Gly Val Gly Lys Ala Ala Leu His Pro Pro Ala 
225                 230                 235                 240 


Leu Ala Val Leu Ser His Thr Pro Asp Gly Ala Thr Gln Thr Ile Ala 
                245                 250                 255     


Trp Val Gly Lys Gly Ile Val Tyr Asp Thr Gly Gly Leu Ser Ile Lys 
            260                 265                 270         


Gly Lys Thr Thr Met Pro Gly Met Lys Arg Asp Cys Gly Gly Ala Ala 
        275                 280                 285             


Ala Val Leu Gly Ala Phe Arg Ala Ala Ile Lys Gln Gly Phe Lys Asp 
    290                 295                 300                 


Asn Leu His Ala Val Phe Cys Leu Ala Glu Asn Ser Val Gly Pro Asn 
305                 310                 315                 320 


Ala Thr Arg Pro Asp Asp Ile His Leu Leu Tyr Ser Gly Lys Thr Val 
                325                 330                 335     


Glu Ile Asn Asn Thr Asp Ala Glu Gly Arg Leu Val Leu Ala Asp Gly 
            340                 345                 350         


Val Ser Tyr Ala Cys Lys Asp Leu Gly Ala Asp Ile Ile Leu Asp Met 
        355                 360                 365             


Ala Thr Leu Thr Gly Ala Gln Gly Ile Ala Thr Gly Lys Tyr His Ala 
    370                 375                 380                 


Ala Val Leu Thr Asn Ser Ala Glu Trp Glu Ala Ala Cys Val Lys Ala 
385                 390                 395                 400 


Gly Arg Lys Cys Gly Asp Leu Val His Pro Leu Val Tyr Cys Pro Glu 
                405                 410                 415     


Leu His Phe Ser Glu Phe Thr Ser Ala Val Ala Asp Met Lys Asn Ser 
            420                 425                 430         


Val Ala Asp Arg Asp Asn Ser Pro Ser Ser Cys Ala Gly Leu Phe Ile 
        435                 440                 445             


Ala Ser His Ile Gly Phe Asp Trp Pro Gly Val Trp Val His Leu Asp 
    450                 455                 460                 


Ile Ala Ala Pro Val His Ala Gly Glu Arg Ala Thr Gly Phe Gly Val 
465                 470                 475                 480 


Ala Leu Leu Leu Ala Leu Phe Gly Arg Ala Ser Glu Asp Pro Leu Leu 
                485                 490                 495     


Asn Leu Val Ser Pro Leu Gly Cys Glu Val Asp Val Glu Glu Gly Asp 
            500                 505                 510         


Leu Gly Arg Asp Ser Lys Arg Arg Arg Leu Val 
        515                 520             


<210> 5891
<211> 456
<212> PRT
<213> Homo sapiens

<400> 5891
Met Ala Asp Gly Gly Ser Glu Arg Ala Asp Gly Arg Ile Val Lys Met 
1               5                   10                  15      


Glu Val Asp Tyr Ser Ala Thr Val Asp Gln Arg Leu Pro Glu Cys Ala 
            20                  25                  30          


Lys Leu Ala Lys Glu Gly Arg Leu Gln Glu Val Ile Glu Thr Leu Leu 
        35                  40                  45              


Ser Leu Glu Lys Gln Thr Arg Thr Ala Ser Asp Met Val Ser Thr Ser 
    50                  55                  60                  


Arg Ile Leu Val Ala Val Val Lys Met Cys Tyr Glu Ala Lys Glu Trp 
65                  70                  75                  80  


Asp Leu Leu Asn Glu Asn Ile Met Leu Leu Ser Lys Arg Arg Ser Gln 
                85                  90                  95      


Leu Lys Gln Ala Val Ala Lys Met Val Gln Gln Cys Cys Thr Tyr Val 
            100                 105                 110         


Glu Glu Ile Thr Asp Leu Pro Ile Lys Leu Arg Leu Ile Asp Thr Leu 
        115                 120                 125             


Arg Met Val Thr Glu Gly Lys Ile Tyr Val Glu Ile Glu Arg Ala Arg 
    130                 135                 140                 


Leu Thr Lys Thr Leu Ala Thr Ile Lys Glu Gln Asn Gly Asp Val Lys 
145                 150                 155                 160 


Glu Ala Ala Ser Ile Leu Gln Glu Leu Gln Val Glu Thr Tyr Gly Ser 
                165                 170                 175     


Met Glu Lys Lys Glu Arg Val Glu Phe Ile Leu Glu Gln Met Arg Leu 
            180                 185                 190         


Cys Leu Ala Val Lys Asp Tyr Ile Arg Thr Gln Ile Ile Ser Lys Lys 
        195                 200                 205             


Ile Asn Thr Lys Phe Phe Gln Glu Glu Asn Thr Glu Lys Leu Lys Leu 
    210                 215                 220                 


Lys Tyr Tyr Asn Leu Met Ile Gln Leu Asp Gln His Glu Gly Ser Tyr 
225                 230                 235                 240 


Leu Ser Ile Cys Lys His Tyr Arg Ala Ile Tyr Asp Thr Pro Cys Ile 
                245                 250                 255     


Gln Ala Glu Ser Glu Lys Trp Gln Gln Ala Leu Lys Ser Val Val Leu 
            260                 265                 270         


Tyr Val Ile Leu Ala Pro Phe Asp Asn Glu Gln Ser Asp Leu Val His 
        275                 280                 285             


Arg Ile Ser Gly Asp Lys Lys Leu Glu Glu Ile Pro Lys Tyr Lys Asp 
    290                 295                 300                 


Leu Leu Lys Leu Phe Thr Thr Met Glu Leu Met Arg Trp Ser Thr Leu 
305                 310                 315                 320 


Val Glu Asp Tyr Gly Met Glu Leu Arg Lys Gly Ser Leu Glu Ser Pro 
                325                 330                 335     


Ala Thr Asp Val Phe Gly Ser Thr Glu Glu Gly Glu Lys Arg Trp Lys 
            340                 345                 350         


Asp Leu Lys Asn Arg Val Val Glu His Asn Ile Arg Ile Met Ala Lys 
        355                 360                 365             


Tyr Tyr Thr Arg Ile Thr Met Lys Arg Met Ala Gln Leu Leu Asp Leu 
    370                 375                 380                 


Ser Val Asp Glu Ser Glu Ala Phe Leu Ser Asn Leu Val Val Asn Lys 
385                 390                 395                 400 


Thr Ile Phe Ala Lys Val Asp Arg Leu Ala Gly Ile Ile Asn Phe Gln 
                405                 410                 415     


Arg Pro Lys Asp Pro Asn Asn Leu Leu Asn Asp Trp Ser Gln Lys Leu 
            420                 425                 430         


Asn Ser Leu Met Ser Leu Val Asn Lys Thr Thr His Leu Ile Ala Lys 
        435                 440                 445             


Glu Glu Met Ile His Asn Leu Gln 
    450                 455     


<210> 5892
<211> 336
<212> PRT
<213> Homo sapiens

<400> 5892
Met Lys Ile Asp Ile His Ser His Ile Leu Pro Lys Glu Trp Pro Asp 
1               5                   10                  15      


Leu Lys Lys Arg Phe Gly Tyr Gly Gly Trp Val Gln Leu Gln His His 
            20                  25                  30          


Ser Lys Gly Glu Ala Lys Leu Leu Lys Asp Gly Lys Val Phe Arg Val 
        35                  40                  45              


Val Arg Glu Asn Cys Trp Asp Pro Glu Val Arg Ile Arg Glu Met Asp 
    50                  55                  60                  


Gln Lys Gly Val Thr Val Gln Ala Leu Ser Thr Val Pro Val Met Phe 
65                  70                  75                  80  


Ser Tyr Trp Ala Lys Pro Glu Asp Thr Leu Asn Leu Cys Gln Leu Leu 
                85                  90                  95      


Asn Asn Asp Leu Ala Ser Thr Val Val Ser Tyr Pro Arg Arg Phe Val 
            100                 105                 110         


Gly Leu Gly Thr Leu Pro Met Gln Ala Pro Glu Leu Ala Val Lys Glu 
        115                 120                 125             


Met Glu Arg Cys Val Lys Glu Leu Gly Phe Pro Gly Val Gln Ile Gly 
    130                 135                 140                 


Thr His Val Asn Glu Trp Asp Leu Asn Ala Gln Glu Leu Phe Pro Val 
145                 150                 155                 160 


Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser Leu Phe Val His Pro Trp 
                165                 170                 175     


Asp Met Gln Met Asp Gly Arg Met Ala Lys Tyr Trp Leu Pro Trp Leu 
            180                 185                 190         


Val Gly Met Pro Ala Glu Thr Thr Ile Ala Ile Cys Ser Met Ile Met 
        195                 200                 205             


Gly Gly Val Phe Glu Lys Phe Pro Lys Leu Lys Val Cys Phe Ala His 
    210                 215                 220                 


Gly Gly Gly Ala Phe Pro Phe Thr Val Gly Arg Ile Ser His Gly Phe 
225                 230                 235                 240 


Ser Met Arg Pro Asp Leu Cys Ala Gln Asp Asn Pro Met Asn Pro Lys 
                245                 250                 255     


Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala Leu Val His Asp Pro Leu 
            260                 265                 270         


Ser Leu Lys Leu Leu Thr Asp Val Ile Gly Lys Asp Lys Val Ile Leu 
        275                 280                 285             


Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu Leu Glu Pro Gly Lys Leu 
    290                 295                 300                 


Ile Glu Ser Met Glu Glu Phe Asp Glu Glu Thr Lys Asn Lys Leu Lys 
305                 310                 315                 320 


Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu Glu Arg Lys Gln Phe Glu 
                325                 330                 335     


<210> 5893
<211> 538
<212> PRT
<213> Homo sapiens

<400> 5893
Met Glu Leu Ser Tyr Gln Thr Leu Lys Phe Thr His Gln Ala Arg Glu 
1               5                   10                  15      


Ala Cys Glu Met Arg Thr Glu Ala Arg Arg Lys Asn Leu Leu Ile Leu 
            20                  25                  30          


Ile Ser His Tyr Leu Thr Gln Glu Gly Tyr Ile Asp Thr Ala Asn Ala 
        35                  40                  45              


Leu Glu Gln Glu Thr Lys Leu Gly Leu Arg Arg Phe Glu Val Cys Asp 
    50                  55                  60                  


Asn Ile Asp Leu Glu Thr Ile Leu Met Glu Tyr Glu Ser Tyr Tyr Phe 
65                  70                  75                  80  


Val Lys Phe Gln Lys Tyr Pro Lys Ile Val Lys Lys Ser Ser Asp Thr 
                85                  90                  95      


Ala Glu Asn Asn Leu Pro Gln Arg Ser Arg Gly Lys Thr Arg Arg Met 
            100                 105                 110         


Met Asn Asp Ser Cys Gln Asn Leu Pro Lys Ile Asn Gln Gln Arg Pro 
        115                 120                 125             


Arg Ser Lys Thr Thr Ala Gly Lys Thr Gly Asp Thr Lys Ser Leu Asn 
    130                 135                 140                 


Lys Glu His Pro Asn Gln Glu Val Val Asp Asn Thr Arg Leu Glu Ser 
145                 150                 155                 160 


Ala Asn Phe Gly Leu His Ile Ser Arg Ile Arg Lys Asp Ser Gly Glu 
                165                 170                 175     


Glu Asn Ala His Pro Arg Arg Gly Gln Ile Ile Asp Phe Gln Gly Leu 
            180                 185                 190         


Leu Thr Asp Ala Ile Lys Gly Ala Thr Ser Glu Leu Ala Leu Asn Thr 
        195                 200                 205             


Phe Asp His Asn Pro Asp Pro Ser Glu Arg Leu Leu Lys Pro Leu Ser 
    210                 215                 220                 


Ala Phe Ile Gly Met Asn Ser Glu Met Arg Glu Leu Ala Ala Val Val 
225                 230                 235                 240 


Ser Arg Asp Ile Tyr Leu His Asn Pro Asn Ile Lys Trp Asn Asp Ile 
                245                 250                 255     


Ile Gly Leu Asp Ala Ala Lys Gln Leu Val Lys Glu Ala Val Val Tyr 
            260                 265                 270         


Pro Ile Arg Tyr Pro Gln Leu Phe Thr Gly Ile Leu Ser Pro Trp Lys 
        275                 280                 285             


Gly Leu Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala 
    290                 295                 300                 


Lys Ala Val Ala Thr Glu Cys Lys Thr Thr Phe Phe Asn Ile Ser Ala 
305                 310                 315                 320 


Ser Thr Ile Val Ser Lys Trp Arg Gly Asp Ser Glu Lys Leu Val Arg 
                325                 330                 335     


Val Leu Phe Glu Leu Ala Arg Tyr His Ala Pro Ser Thr Ile Phe Leu 
            340                 345                 350         


Asp Glu Leu Glu Ser Val Met Ser Gln Arg Gly Thr Ala Ser Gly Gly 
        355                 360                 365             


Glu His Glu Gly Ser Leu Arg Met Lys Thr Glu Leu Leu Val Gln Met 
    370                 375                 380                 


Asp Gly Leu Ala Arg Ser Glu Asp Leu Val Phe Val Leu Ala Ala Ser 
385                 390                 395                 400 


Asn Leu Pro Trp Glu Leu Asp Cys Ala Met Leu Arg Arg Leu Glu Lys 
                405                 410                 415     


Arg Ile Leu Val Asp Leu Pro Ser Arg Glu Ala Arg Gln Ala Met Ile 
            420                 425                 430         


Tyr His Trp Leu Pro Pro Val Ser Lys Ser Arg Ala Leu Glu Leu His 
        435                 440                 445             


Thr Glu Leu Glu Tyr Ser Val Leu Ser Gln Glu Thr Glu Gly Tyr Ser 
    450                 455                 460                 


Gly Ser Asp Ile Lys Leu Val Cys Arg Glu Ala Ala Met Arg Pro Val 
465                 470                 475                 480 


Arg Lys Ile Phe Asp Ala Leu Glu Asn His Gln Ser Glu Ser Ser Asp 
                485                 490                 495     


Leu Pro Arg Ile Gln Leu Asp Ile Val Thr Thr Ala Asp Phe Leu Asp 
            500                 505                 510         


Val Leu Thr His Thr Lys Pro Ser Ala Lys Asn Leu Ala Gln Arg Tyr 
        515                 520                 525             


Ser Asp Trp Gln Arg Glu Phe Glu Ser Val 
    530                 535             


<210> 5894
<211> 168
<212> PRT
<213> Homo sapiens

<400> 5894
Met Ala Glu Gly Ser Arg Ile Pro Gln Ala Arg Ala Leu Leu Gln Gln 
1               5                   10                  15      


Cys Leu His Ala Arg Leu Gln Ile Arg Pro Ala Asp Gly Asp Val Ala 
            20                  25                  30          


Ala Gln Trp Val Glu Val Gln Arg Gly Leu Val Ile Tyr Val Cys Phe 
        35                  40                  45              


Phe Lys Gly Ala Asp Lys Glu Leu Leu Pro Lys Met Val Asn Thr Leu 
    50                  55                  60                  


Leu Asn Val Lys Leu Ser Glu Thr Glu Asn Gly Lys His Val Ser Ile 
65                  70                  75                  80  


Leu Asp Leu Pro Gly Asn Ile Leu Ile Ile Pro Gln Ala Thr Leu Gly 
                85                  90                  95      


Gly Arg Leu Lys Gly Arg Asn Met Gln Tyr His Ser Asn Ser Gly Lys 
            100                 105                 110         


Glu Glu Gly Phe Glu Leu Tyr Ser Gln Phe Val Thr Leu Cys Glu Lys 
        115                 120                 125             


Glu Val Ala Ala Asn Ser Lys Cys Ala Glu Ala Arg Val Val Val Glu 
    130                 135                 140                 


His Gly Thr Tyr Gly Asn Arg Gln Val Leu Lys Leu Asp Thr Asn Gly 
145                 150                 155                 160 


Pro Phe Thr His Leu Ile Glu Phe 
                165             


<210> 5895
<211> 587
<212> PRT
<213> Homo sapiens

<400> 5895
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe 
        35                  40                  45              


Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu 
    50                  55                  60                  


Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys 
65                  70                  75                  80  


Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile 
                85                  90                  95      


Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile Thr Ala Gly Ala 
            100                 105                 110         


Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe Gly Pro Asp Gly 
        115                 120                 125             


Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser Ala Cys Phe Thr Leu 
    130                 135                 140                 


Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile Gly Gly Gly Lys 
145                 150                 155                 160 


Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys Ser Ser Ala Gln 
                165                 170                 175     


Gly Lys Pro Leu Ala Leu Lys Val Phe Val Ala Gly Arg Asn Arg Leu 
            180                 185                 190         


Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe Arg Val Ile Gly 
        195                 200                 205             


Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile Asn His Pro Gly 
    210                 215                 220                 


Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro Leu Leu Arg Val 
225                 230                 235                 240 


Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly Ala Val Ala Met 
                245                 250                 255     


Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val Ile Asn Phe Gly 
            260                 265                 270         


Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile Ala Asp Ala Ile 
        275                 280                 285             


Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu Ser Phe Cys Glu 
    290                 295                 300                 


Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala Met Ala Asp Lys 
305                 310                 315                 320 


Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr Leu Gly Glu Glu 
                325                 330                 335     


Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe Asn Met Ala Lys 
            340                 345                 350         


Val Leu Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Asp Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Gln Gln 
385                 390                 395                 400 


Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg Lys Ile Leu Asp 
                405                 410                 415     


Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser Pro Pro Pro Ala 
            420                 425                 430         


Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu Lys Leu Leu Arg 
        435                 440                 445             


Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln Thr Asp Thr Ser 
    450                 455                 460                 


Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val Ser Ser Val Phe 
465                 470                 475                 480 


Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp Ala Val Asp Ala 
                485                 490                 495     


Leu Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn Ser Asn Thr Phe 
            500                 505                 510         


Leu Thr Arg Leu Leu Val His Met Gly Leu Leu Lys Ser Glu Asp Lys 
        515                 520                 525             


Val Lys Ala Ile Ala Asn Leu Tyr Gly Pro Leu Met Ala Leu Asn His 
    530                 535                 540                 


Met Val Gln Gln Asp Tyr Phe Pro Lys Ala Leu Ala Pro Leu Leu Leu 
545                 550                 555                 560 


Ala Phe Val Thr Lys Pro Asn Ser Ala Leu Glu Ser Cys Ser Phe Ala 
                565                 570                 575     


Arg His Ser Leu Leu Gln Thr Leu Tyr Lys Val 
            580                 585         


<210> 5896
<211> 842
<212> PRT
<213> Homo sapiens

<400> 5896
Met Asp Ile Ser Lys Gly Leu Pro Gly Met Gln Gly Gly Leu His Ile 
1               5                   10                  15      


Trp Ile Ser Glu Asn Arg Lys Met Val Pro Val Pro Glu Gly Ala Tyr 
            20                  25                  30          


Gly Asn Phe Phe Glu Glu His Cys Tyr Val Ile Leu His Val Pro Gln 
        35                  40                  45              


Ser Pro Lys Ala Thr Gln Gly Ala Ser Ser Asp Leu His Tyr Trp Val 
    50                  55                  60                  


Gly Lys Gln Ala Gly Ala Glu Ala Gln Gly Ala Ala Glu Ala Phe Gln 
65                  70                  75                  80  


Gln Arg Leu Gln Asp Glu Leu Gly Gly Gln Thr Val Leu His Arg Glu 
                85                  90                  95      


Ala Gln Gly His Glu Ser Asp Cys Phe Cys Ser Tyr Phe Arg Pro Gly 
            100                 105                 110         


Ile Ile Tyr Arg Lys Gly Gly Leu Ala Ser Asp Leu Lys His Val Glu 
        115                 120                 125             


Thr Asn Leu Phe Asn Ile Gln Arg Leu Leu His Ile Lys Gly Arg Lys 
    130                 135                 140                 


His Val Ser Ala Thr Glu Val Glu Leu Ser Trp Asn Ser Phe Asn Lys 
145                 150                 155                 160 


Gly Asp Ile Phe Leu Leu Asp Leu Gly Lys Met Met Ile Gln Trp Asn 
                165                 170                 175     


Gly Pro Lys Thr Ser Ile Ser Glu Lys Ala Arg Gly Leu Ala Leu Thr 
            180                 185                 190         


Tyr Ser Leu Arg Asp Arg Glu Arg Gly Gly Gly Arg Ala Gln Ile Gly 
        195                 200                 205             


Val Val Asp Asp Glu Ala Lys Ala Pro Asp Leu Met Gln Ile Met Glu 
    210                 215                 220                 


Ala Val Leu Gly Arg Arg Val Gly Ser Leu Arg Ala Ala Thr Pro Ser 
225                 230                 235                 240 


Lys Asp Ile Asn Gln Leu Gln Lys Ala Asn Val Arg Leu Tyr His Val 
                245                 250                 255     


Tyr Glu Lys Gly Lys Asp Leu Leu Gln Glu Glu Asp Phe Tyr Ile Leu 
            260                 265                 270         


Asp Gln Gly Gly Phe Lys Ile Tyr Val Trp Gln Gly Arg Met Ser Ser 
        275                 280                 285             


Leu Gln Glu Arg Lys Ala Ala Phe Ser Arg Ala Val Gly Phe Ile Gln 
    290                 295                 300                 


Ala Lys Gly Tyr Pro Thr Tyr Thr Asn Val Glu Val Val Asn Asp Gly 
305                 310                 315                 320 


Ala Glu Ser Ala Ala Phe Lys Gln Leu Phe Arg Thr Trp Ser Glu Lys 
                325                 330                 335     


Arg Arg Arg Asn Gln Lys Leu Gly Gly Arg Asp Lys Ser Ile His Val 
            340                 345                 350         


Lys Leu Asp Val Gly Lys Leu His Thr Gln Pro Lys Leu Ala Ala Gln 
        355                 360                 365             


Leu Arg Met Val Asp Asp Gly Ser Gly Lys Val Glu Val Trp Cys Ile 
    370                 375                 380                 


Gln Asp Leu His Arg Gln Pro Val Asp Pro Lys Arg His Gly Gln Leu 
385                 390                 395                 400 


Cys Ala Gly Asn Cys Tyr Leu Val Leu Tyr Thr Tyr Gln Arg Leu Gly 
                405                 410                 415     


Arg Val Gln Tyr Ile Leu Tyr Leu Trp Gln Gly His Gln Ala Thr Ala 
            420                 425                 430         


Asp Glu Ile Glu Ala Leu Asn Ser Asn Ala Glu Glu Leu Asp Val Met 
        435                 440                 445             


Tyr Gly Gly Val Leu Val Gln Glu His Val Thr Met Gly Ser Glu Pro 
    450                 455                 460                 


Pro His Phe Leu Ala Ile Phe Gln Gly Gln Leu Val Ile Phe Gln Glu 
465                 470                 475                 480 


Arg Ala Gly His His Gly Lys Gly Gln Ser Ala Ser Thr Thr Arg Leu 
                485                 490                 495     


Phe Gln Val Gln Gly Thr Asp Ser His Asn Thr Arg Thr Met Glu Val 
            500                 505                 510         


Pro Ala Arg Ala Ser Ser Leu Asn Ser Ser Asp Ile Phe Leu Leu Val 
        515                 520                 525             


Thr Ala Ser Val Cys Tyr Leu Trp Phe Gly Lys Gly Cys Asn Gly Asp 
    530                 535                 540                 


Gln Arg Glu Met Ala Arg Val Val Val Thr Val Ile Ser Arg Lys Asn 
545                 550                 555                 560 


Glu Glu Thr Val Leu Glu Gly Gln Glu Pro Pro His Phe Trp Glu Ala 
                565                 570                 575     


Leu Gly Gly Arg Ala Pro Tyr Pro Ser Asn Lys Arg Leu Pro Glu Glu 
            580                 585                 590         


Val Pro Ser Phe Gln Pro Arg Leu Phe Glu Cys Ser Ser His Met Gly 
        595                 600                 605             


Cys Leu Val Leu Ala Glu Val Gly Phe Phe Ser Gln Glu Asp Leu Asp 
    610                 615                 620                 


Lys Tyr Asp Ile Met Leu Leu Asp Thr Trp Gln Glu Ile Phe Leu Trp 
625                 630                 635                 640 


Leu Gly Glu Ala Ala Ser Glu Trp Lys Glu Ala Val Ala Trp Gly Gln 
                645                 650                 655     


Glu Tyr Leu Lys Thr His Pro Ala Gly Arg Ser Pro Ala Thr Pro Ile 
            660                 665                 670         


Val Leu Val Lys Gln Gly His Glu Pro Pro Thr Phe Ile Gly Trp Phe 
        675                 680                 685             


Phe Thr Trp Asp Pro Tyr Lys Trp Thr Ser His Pro Ser His Lys Glu 
    690                 695                 700                 


Val Val Asp Gly Ser Pro Ala Ala Ala Ser Thr Ile Ser Glu Ile Thr 
705                 710                 715                 720 


Ala Glu Val Asn Asn Leu Arg Leu Ser Arg Trp Pro Gly Asn Gly Arg 
                725                 730                 735     


Ala Gly Ala Val Ala Leu Gln Ala Leu Lys Gly Ser Gln Asp Ser Ser 
            740                 745                 750         


Glu Asn Asp Leu Val Arg Ser Pro Lys Ser Ala Gly Ser Arg Thr Ser 
        755                 760                 765             


Ser Ser Val Ser Ser Thr Ser Ala Thr Ile Asn Gly Gly Leu Arg Arg 
    770                 775                 780                 


Glu Gln Leu Met His Gln Ala Val Glu Asp Leu Pro Glu Gly Val Asp 
785                 790                 795                 800 


Pro Ala Arg Arg Glu Phe Tyr Leu Ser Asp Ser Asp Phe Gln Asp Ile 
                805                 810                 815     


Phe Gly Lys Ser Lys Glu Glu Phe Tyr Ser Met Ala Thr Trp Arg Gln 
            820                 825                 830         


Arg Gln Glu Lys Lys Gln Leu Gly Phe Phe 
        835                 840         


<210> 5897
<211> 539
<212> PRT
<213> Homo sapiens

<400> 5897
Met Asp Ala Met Ala Ser Pro Gly Lys Asp Asn Tyr Arg Met Lys Ser 
1               5                   10                  15      


Tyr Lys Asn Lys Ala Leu Asn Pro Gln Glu Met Arg Arg Arg Arg Glu 
            20                  25                  30          


Glu Glu Gly Ile Gln Leu Arg Lys Gln Lys Arg Glu Glu Gln Leu Phe 
        35                  40                  45              


Lys Arg Arg Asn Val Tyr Leu Pro Arg Asn Asp Glu Ser Met Leu Glu 
    50                  55                  60                  


Ser Pro Ile Gln Asp Pro Asp Ile Ser Ser Thr Val Pro Ile Pro Glu 
65                  70                  75                  80  


Glu Glu Val Val Thr Thr Asp Met Val Gln Met Ile Phe Ser Asn Asn 
                85                  90                  95      


Ala Asp Gln Gln Leu Thr Ala Thr Gln Lys Phe Arg Lys Leu Leu Ser 
            100                 105                 110         


Lys Glu Pro Asn Pro Pro Ile Asp Gln Val Ile Gln Lys Pro Gly Val 
        115                 120                 125             


Val Gln Arg Phe Val Lys Phe Leu Glu Arg Asn Glu Asn Cys Thr Leu 
    130                 135                 140                 


Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser Gly Thr Phe 
145                 150                 155                 160 


Leu His Thr Lys Val Val Ile Glu Thr Gly Ala Val Pro Ile Phe Ile 
                165                 170                 175     


Lys Leu Leu Asn Ser Glu His Glu Asp Val Gln Glu Gln Ala Val Trp 
            180                 185                 190         


Ala Leu Gly Asn Ile Ala Gly Asp Asn Ala Glu Cys Arg Asp Phe Val 
        195                 200                 205             


Leu Asn Cys Glu Ile Leu Pro Pro Leu Leu Glu Leu Leu Thr Asn Ser 
    210                 215                 220                 


Asn Arg Leu Thr Thr Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu 
225                 230                 235                 240 


Cys Arg Gly Lys Asn Pro Pro Pro Asn Phe Ser Lys Val Ser Pro Cys 
                245                 250                 255     


Leu Asn Val Leu Ser Arg Leu Leu Phe Ser Ser Asp Pro Asp Val Leu 
            260                 265                 270         


Ala Asp Val Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Asp 
        275                 280                 285             


Lys Ile Gln Ala Val Ile Asp Ser Gly Val Cys Arg Arg Leu Val Glu 
    290                 295                 300                 


Leu Leu Met His Asn Asp Tyr Lys Val Val Ser Pro Ala Leu Arg Ala 
305                 310                 315                 320 


Val Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu 
                325                 330                 335     


Asn Cys Ser Ala Leu Pro Cys Leu Leu His Leu Leu Ser Ser Pro Lys 
            340                 345                 350         


Glu Ser Ile Arg Lys Glu Ala Cys Trp Thr Val Ser Asn Ile Thr Ala 
        355                 360                 365             


Gly Asn Arg Ala Gln Ile Gln Ala Val Ile Asp Ala Asn Ile Phe Pro 
    370                 375                 380                 


Val Leu Ile Glu Ile Leu Gln Lys Ala Glu Phe Arg Thr Arg Lys Glu 
385                 390                 395                 400 


Ala Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Thr Pro Glu Gln 
                405                 410                 415     


Ile Arg Tyr Leu Val Ala Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu 
            420                 425                 430         


Leu Thr Val Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu 
        435                 440                 445             


Glu Asn Ile Leu Arg Leu Gly Glu Gln Glu Ser Lys Gln Asn Gly Ile 
    450                 455                 460                 


Gly Ile Asn Pro Tyr Cys Ala Leu Ile Glu Glu Ala Tyr Gly Leu Asp 
465                 470                 475                 480 


Lys Ile Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys 
                485                 490                 495     


Ala Phe Asp Leu Ile Glu His Tyr Phe Gly Val Glu Glu Asp Asp Pro 
            500                 505                 510         


Ser Ile Val Pro Gln Val Asp Glu Asn Gln Gln Gln Phe Ile Phe Gln 
        515                 520                 525             


Gln Gln Glu Ala Pro Met Asp Gly Phe Gln Leu 
    530                 535                 


<210> 5898
<211> 1244
<212> PRT
<213> Homo sapiens

<400> 5898
Met Leu Ile Lys Glu Tyr His Ile Leu Leu Pro Met Ser Leu Asp Glu 
1               5                   10                  15      


Tyr Gln Val Ala Gln Leu Tyr Met Ile Gln Lys Lys Ser Arg Glu Glu 
            20                  25                  30          


Ser Ser Gly Glu Gly Ser Gly Val Glu Ile Leu Ala Asn Arg Pro Tyr 
        35                  40                  45              


Thr Asp Gly Pro Gly Gly Ser Gly Gln Tyr Thr His Lys Val Tyr His 
    50                  55                  60                  


Val Gly Ser His Ile Pro Gly Trp Phe Arg Ala Leu Leu Pro Lys Ala 
65                  70                  75                  80  


Ala Leu Gln Val Glu Glu Glu Ser Trp Asn Ala Tyr Pro Tyr Thr Arg 
                85                  90                  95      


Thr Arg Tyr Thr Cys Pro Phe Val Glu Lys Phe Ser Ile Glu Ile Glu 
            100                 105                 110         


Thr Tyr Tyr Leu Pro Asp Gly Gly Gln Gln Pro Asn Val Phe Asn Leu 
        115                 120                 125             


Ser Gly Ala Glu Arg Arg Gln Arg Ile Leu Asp Thr Ile Asp Ile Val 
    130                 135                 140                 


Arg Asp Ala Val Ala Pro Gly Glu Tyr Lys Ala Glu Glu Asp Pro Arg 
145                 150                 155                 160 


Leu Tyr His Ser Val Lys Thr Gly Arg Gly Pro Leu Ser Asp Asp Trp 
                165                 170                 175     


Ala Arg Thr Ala Ala Gln Thr Gly Pro Leu Met Cys Ala Tyr Lys Leu 
            180                 185                 190         


Cys Lys Val Glu Phe Arg Tyr Trp Gly Met Gln Ala Lys Ile Glu Gln 
        195                 200                 205             


Phe Ile His Asp Val Gly Leu Arg Arg Val Met Leu Arg Ala His Arg 
    210                 215                 220                 


Gln Ala Trp Cys Trp Gln Asp Glu Trp Thr Glu Leu Ser Met Ala Asp 
225                 230                 235                 240 


Ile Arg Ala Leu Glu Glu Glu Thr Ala Arg Met Leu Ala Gln Arg Met 
                245                 250                 255     


Ala Lys Cys Asn Thr Gly Ser Glu Gly Ser Glu Ala Gln Pro Pro Gly 
            260                 265                 270         


Lys Pro Ser Thr Glu Ala Arg Ser Ala Ala Ser Asn Thr Gly Thr Pro 
        275                 280                 285             


Asp Gly Pro Glu Ala Pro Pro Gly Pro Asp Ala Ser Pro Asp Ala Ser 
    290                 295                 300                 


Phe Gly Lys Gln Trp Ser Ser Ser Ser Arg Ser Ser Tyr Ser Ser Gln 
305                 310                 315                 320 


His Gly Gly Ala Val Ser Pro Gln Ser Leu Ser Glu Trp Arg Met Gln 
                325                 330                 335     


Asn Ile Ala Arg Asp Ser Glu Asn Ser Ser Glu Glu Glu Phe Phe Asp 
            340                 345                 350         


Ala His Glu Gly Phe Ser Asp Ser Glu Glu Val Phe Pro Lys Glu Met 
        355                 360                 365             


Thr Lys Trp Asn Ser Asn Asp Phe Ile Asp Ala Phe Ala Ser Pro Val 
    370                 375                 380                 


Glu Ala Glu Gly Thr Pro Glu Pro Gly Ala Glu Ala Ala Lys Gly Ile 
385                 390                 395                 400 


Glu Asp Gly Ala Gln Ala Pro Arg Asp Ser Glu Gly Leu Asp Gly Ala 
                405                 410                 415     


Gly Glu Leu Gly Ala Glu Ala Cys Ala Val His Ala Leu Phe Leu Ile 
            420                 425                 430         


Leu His Ser Gly Asn Ile Leu Asp Ser Gly Pro Gly Asp Ala Asn Ser 
        435                 440                 445             


Lys Gln Ala Asp Val Gln Thr Leu Ser Ser Ala Phe Glu Ala Val Thr 
    450                 455                 460                 


Arg Ile His Phe Pro Glu Ala Leu Gly His Val Ala Leu Arg Leu Val 
465                 470                 475                 480 


Pro Cys Pro Pro Ile Cys Ala Ala Ala Tyr Ala Leu Val Ser Asn Leu 
                485                 490                 495     


Ser Pro Tyr Ser His Asp Gly Asp Ser Leu Ser Arg Ser Gln Asp His 
            500                 505                 510         


Ile Pro Leu Ala Ala Leu Pro Leu Leu Ala Thr Ser Ser Ser Arg Tyr 
        515                 520                 525             


Gln Gly Ala Val Ala Thr Val Ile Ala Arg Thr Asn Gln Ala Tyr Ser 
    530                 535                 540                 


Ala Phe Leu Arg Ser Pro Glu Gly Ala Gly Phe Cys Gly Gln Val Ala 
545                 550                 555                 560 


Leu Ile Gly Asp Gly Val Gly Gly Ile Leu Gly Phe Asp Ala Leu Cys 
                565                 570                 575     


His Ser Ala Asn Ala Gly Thr Gly Ser Arg Gly Ser Ser Arg Arg Gly 
            580                 585                 590         


Ser Met Asn Asn Glu Leu Leu Ser Pro Glu Phe Gly Pro Val Arg Asp 
        595                 600                 605             


Pro Leu Ala Asp Gly Val Glu Gly Leu Gly Arg Gly Ser Pro Glu Pro 
    610                 615                 620                 


Ser Ala Leu Pro Pro Gln Arg Ile Pro Ser Asp Met Ala Ser Pro Glu 
625                 630                 635                 640 


Pro Glu Gly Ser Gln Asn Ser Leu Gln Ala Ala Pro Ala Thr Thr Ser 
                645                 650                 655     


Ser Trp Glu Pro Arg Arg Ala Ser Thr Ala Phe Cys Pro Pro Ala Ala 
            660                 665                 670         


Ser Ser Glu Ala Pro Asp Gly Pro Ser Ser Thr Ala Arg Leu Asp Phe 
        675                 680                 685             


Lys Val Ser Gly Phe Phe Leu Phe Gly Ser Pro Leu Gly Leu Val Leu 
    690                 695                 700                 


Ala Leu Arg Lys Thr Val Met Pro Ala Leu Glu Ala Ala Gln Met Arg 
705                 710                 715                 720 


Pro Ala Cys Glu Gln Ile Tyr Asn Leu Phe His Ala Ala Asp Pro Cys 
                725                 730                 735     


Ala Ser Arg Leu Glu Pro Leu Leu Ala Pro Lys Phe Gln Ala Ile Ala 
            740                 745                 750         


Pro Leu Thr Val Pro Arg Tyr Gln Lys Phe Pro Leu Gly Asp Gly Ser 
        755                 760                 765             


Ser Leu Leu Leu Ala Asp Thr Leu Gln Thr His Ser Ser Leu Phe Leu 
    770                 775                 780                 


Glu Glu Leu Glu Met Leu Val Pro Ser Thr Pro Thr Ser Thr Ser Gly 
785                 790                 795                 800 


Ala Phe Trp Lys Gly Ser Glu Leu Ala Thr Asp Pro Pro Ala Gln Pro 
                805                 810                 815     


Ala Ala Pro Ser Thr Thr Ser Glu Val Val Lys Ile Leu Glu Arg Trp 
            820                 825                 830         


Trp Gly Thr Lys Arg Ile Asp Tyr Ser Leu Tyr Cys Pro Glu Ala Leu 
        835                 840                 845             


Thr Ala Phe Pro Thr Val Thr Leu Pro His Leu Phe His Ala Ser Tyr 
    850                 855                 860                 


Trp Glu Ser Ala Asp Val Val Ala Phe Ile Leu Arg Gln Val Ile Glu 
865                 870                 875                 880 


Lys Glu Arg Pro Gln Leu Ala Glu Cys Glu Glu Pro Ser Ile Tyr Ser 
                885                 890                 895     


Pro Ala Phe Pro Arg Glu Lys Trp Gln Arg Lys Arg Thr Gln Val Lys 
            900                 905                 910         


Ile Arg Asn Val Thr Ser Asn His Arg Ala Ser Asp Thr Val Val Cys 
        915                 920                 925             


Glu Gly Arg Pro Gln Val Leu Ser Gly Arg Phe Met Tyr Gly Pro Leu 
    930                 935                 940                 


Asp Val Val Thr Leu Thr Gly Glu Lys Val Asp Val Tyr Ile Met Thr 
945                 950                 955                 960 


Gln Pro Leu Ser Gly Lys Trp Ile His Phe Gly Thr Glu Val Thr Asn 
                965                 970                 975     


Ser Ser Gly Arg Leu Thr Phe Pro Val Pro Pro Glu Arg Ala Leu Gly 
            980                 985                 990         


Ile Gly Val Tyr Pro Val Arg Met  Val Val Arg Gly Asp  His Thr Tyr 
        995                 1000                 1005             


Ala Glu  Cys Cys Leu Thr Val  Val Ala Arg Gly Thr  Glu Ala Val 
    1010                 1015                 1020             


Val Phe  Ser Ile Asp Gly Ser  Phe Thr Ala Ser Val  Ser Ile Met 
    1025                 1030                 1035             


Gly Ser  Asp Pro Lys Val Arg  Ala Gly Ala Val Asp  Val Val Arg 
    1040                 1045                 1050             


His Trp  Gln Asp Ser Gly Tyr  Leu Ile Val Tyr Val  Thr Gly Arg 
    1055                 1060                 1065             


Pro Asp  Met Gln Lys His Arg  Val Val Ala Trp Leu  Ser Gln His 
    1070                 1075                 1080             


Asn Phe  Pro His Gly Val Val  Ser Phe Cys Asp Gly  Leu Thr His 
    1085                 1090                 1095             


Asp Pro  Leu Arg Gln Lys Ala  Met Phe Leu Gln Ser  Leu Val Gln 
    1100                 1105                 1110             


Glu Val  Glu Leu Asn Ile Val  Ala Gly Tyr Gly Ser  Pro Lys Asp 
    1115                 1120                 1125             


Val Ala  Val Tyr Ala Ala Leu  Gly Leu Ser Pro Ser  Gln Thr Tyr 
    1130                 1135                 1140             


Ile Val  Gly Arg Ala Val Arg  Lys Leu Gln Ala Gln  Cys Gln Phe 
    1145                 1150                 1155             


Leu Ser  Asp Gly Tyr Val Ala  His Leu Gly Gln Leu  Glu Ala Gly 
    1160                 1165                 1170             


Ser His  Ser His Ala Ser Ser  Gly Pro Pro Arg Ala  Ala Leu Gly 
    1175                 1180                 1185             


Lys Ser  Ser Tyr Gly Val Ala  Ala Pro Val Asp Phe  Leu Arg Lys 
    1190                 1195                 1200             


Gln Ser  Gln Leu Leu Arg Ser  Arg Gly Pro Ser Gln  Ala Glu Arg 
    1205                 1210                 1215             


Glu Gly  Pro Gly Thr Pro Pro  Thr Thr Leu Ala Arg  Gly Lys Ala 
    1220                 1225                 1230             


Arg Ser  Ile Ser Leu Lys Leu  Asp Ser Glu Glu 
    1235                 1240                 


<210> 5899
<211> 293
<212> PRT
<213> Homo sapiens

<400> 5899
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn 
145                 150                 155                 160 


Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala 
                165                 170                 175     


Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu 
            180                 185                 190         


Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys 
        195                 200                 205             


Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp 
    210                 215                 220                 


Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val 
225                 230                 235                 240 


Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn Ser Ala 
                245                 250                 255     


Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser Ser Asp 
            260                 265                 270         


Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys Gly Thr 
        275                 280                 285             


Pro Val His Ser Ser 
    290             


<210> 5900
<211> 82
<212> PRT
<213> Homo sapiens

<400> 5900
Met Ser Glu Gly Glu Ser Gln Thr Val Leu Ser Ser Gly Ser Asp Pro 
1               5                   10                  15      


Lys Val Glu Ser Ser Ser Ser Ala Pro Gly Leu Thr Ser Val Ser Pro 
            20                  25                  30          


Pro Val Thr Ser Thr Thr Ser Ala Ala Ser Pro Glu Glu Glu Glu Glu 
        35                  40                  45              


Ser Glu Asp Glu Ser Glu Ile Leu Glu Glu Ser Pro Cys Gly Arg Trp 
    50                  55                  60                  


Gln Lys Arg Arg Glu Glu Val Asn Gln Arg Asn Val Pro Gly Ile Asp 
65                  70                  75                  80  


Ser Ala 
        


<210> 5901
<211> 1685
<212> PRT
<213> Homo sapiens

<400> 5901
Met Ser Leu Pro Phe Tyr Gln Arg Cys His Gln His Tyr Asp Leu Ser 
1               5                   10                  15      


Tyr Arg Asn Lys Asp Val Arg Ser Thr Val Ser His Tyr Gln Arg Glu 
            20                  25                  30          


Lys Lys Arg Ser Ala Val Tyr Thr Gln Gly Ser Thr Ala Tyr Ser Ser 
        35                  40                  45              


Arg Ser Ser Ala Ala His Arg Arg Glu Ser Glu Ala Phe Arg Arg Ala 
    50                  55                  60                  


Ser Ala Ser Ser Ser Gln Gln Gln Ala Ser Gln His Ala Leu Ser Ser 
65                  70                  75                  80  


Glu Val Ser Arg Lys Ala Ala Ser Ala Tyr Asp Tyr Gly Ser Ser His 
                85                  90                  95      


Gly Leu Thr Asp Ser Ser Leu Leu Leu Asp Asp Tyr Ser Ser Lys Leu 
            100                 105                 110         


Ser Pro Lys Pro Lys Arg Ala Lys His Ser Leu Leu Ser Gly Glu Glu 
        115                 120                 125             


Lys Glu Asn Leu Pro Ser Asp Tyr Met Val Pro Ile Phe Ser Gly Arg 
    130                 135                 140                 


Gln Lys His Val Ser Gly Ile Thr Asp Thr Glu Glu Glu Arg Ile Lys 
145                 150                 155                 160 


Glu Ala Ala Ala Tyr Ile Ala Gln Arg Asn Leu Leu Ala Ser Glu Glu 
                165                 170                 175     


Gly Ile Thr Thr Ser Lys Gln Ser Thr Ala Ser Lys Gln Thr Thr Ala 
            180                 185                 190         


Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser 
        195                 200                 205             


Thr Ala Ser Arg Gln Ser Thr Ala Ser Arg Gln Ser Val Val Ser Lys 
    210                 215                 220                 


Gln Ala Thr Ser Ala Leu Gln Gln Glu Glu Thr Ser Glu Lys Lys Ser 
225                 230                 235                 240 


Arg Lys Val Val Ile Arg Glu Lys Ala Glu Arg Leu Ser Leu Arg Lys 
                245                 250                 255     


Thr Leu Glu Glu Thr Glu Thr Tyr His Ala Lys Leu Asn Glu Asp His 
            260                 265                 270         


Leu Leu His Ala Pro Glu Phe Ile Ile Lys Pro Arg Ser His Thr Val 
        275                 280                 285             


Trp Glu Lys Glu Asn Val Lys Leu His Cys Ser Ile Ala Gly Trp Pro 
    290                 295                 300                 


Glu Pro Arg Val Thr Trp Tyr Lys Asn Gln Val Pro Ile Asn Val His 
305                 310                 315                 320 


Ala Asn Pro Gly Lys Tyr Ile Ile Glu Ser Arg Tyr Gly Met His Thr 
                325                 330                 335     


Leu Glu Ile Asn Gly Cys Asp Phe Glu Asp Thr Ala Gln Tyr Arg Ala 
            340                 345                 350         


Ser Ala Met Asn Val Lys Gly Glu Leu Ser Ala Tyr Ala Ser Val Val 
        355                 360                 365             


Val Lys Arg Tyr Lys Gly Glu Phe Asp Glu Thr Arg Phe His Ala Gly 
    370                 375                 380                 


Ala Ser Thr Met Pro Leu Ser Phe Gly Val Thr Pro Tyr Gly Tyr Ala 
385                 390                 395                 400 


Ser Arg Phe Glu Ile His Phe Asp Asp Lys Phe Asp Val Ser Phe Gly 
                405                 410                 415     


Arg Glu Gly Glu Thr Met Ser Leu Gly Cys Arg Val Val Ile Thr Pro 
            420                 425                 430         


Glu Ile Lys His Phe Gln Pro Glu Ile Gln Trp Tyr Arg Asn Gly Val 
        435                 440                 445             


Pro Leu Ser Pro Ser Lys Trp Val Gln Thr Leu Trp Ser Gly Glu Arg 
    450                 455                 460                 


Ala Thr Leu Thr Phe Ser His Leu Asn Lys Glu Asp Glu Gly Leu Tyr 
465                 470                 475                 480 


Thr Ile Arg Val Arg Met Gly Glu Tyr Tyr Glu Gln Tyr Ser Ala Tyr 
                485                 490                 495     


Val Phe Val Arg Asp Ala Asp Ala Glu Ile Glu Gly Ala Pro Ala Ala 
            500                 505                 510         


Pro Leu Asp Val Lys Cys Leu Glu Ala Asn Lys Asp Tyr Ile Ile Ile 
        515                 520                 525             


Ser Trp Lys Gln Pro Ala Val Asp Gly Gly Ser Pro Ile Leu Gly Tyr 
    530                 535                 540                 


Phe Ile Asp Lys Cys Glu Val Gly Thr Asp Ser Trp Ser Gln Cys Asn 
545                 550                 555                 560 


Asp Thr Pro Val Lys Phe Ala Arg Phe Pro Val Thr Gly Leu Ile Glu 
                565                 570                 575     


Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Lys Met Gly Ile 
            580                 585                 590         


Gly Phe Pro Ser Arg Val Ser Glu Pro Val Ala Ala Leu Asp Pro Ala 
        595                 600                 605             


Glu Lys Ala Arg Leu Lys Ser Arg Pro Ser Ala Pro Trp Thr Gly Gln 
    610                 615                 620                 


Ile Ile Val Thr Glu Glu Glu Pro Ser Glu Gly Ile Val Pro Gly Pro 
625                 630                 635                 640 


Pro Thr Asp Leu Ser Val Thr Glu Ala Thr Arg Ser Tyr Val Val Leu 
                645                 650                 655     


Ser Trp Lys Pro Pro Gly Gln Arg Gly His Glu Gly Ile Met Tyr Phe 
            660                 665                 670         


Val Glu Lys Cys Glu Ala Gly Thr Glu Asn Trp Gln Arg Val Asn Thr 
        675                 680                 685             


Glu Leu Pro Val Lys Ser Pro Arg Phe Ala Leu Phe Asp Leu Ala Glu 
    690                 695                 700                 


Gly Lys Ser Tyr Cys Phe Arg Val Arg Cys Ser Asn Ser Ala Gly Val 
705                 710                 715                 720 


Gly Glu Pro Ser Glu Ala Thr Glu Val Thr Val Val Gly Asp Lys Leu 
                725                 730                 735     


Asp Ile Pro Lys Ala Pro Gly Lys Ile Ile Pro Ser Arg Asn Thr Asp 
            740                 745                 750         


Thr Ser Val Val Val Ser Trp Glu Glu Ser Lys Asp Ala Lys Glu Leu 
        755                 760                 765             


Val Gly Tyr Tyr Ile Glu Ala Ser Val Ala Gly Ser Gly Lys Trp Glu 
    770                 775                 780                 


Pro Cys Asn Asn Asn Pro Val Lys Gly Ser Arg Phe Thr Cys His Gly 
785                 790                 795                 800 


Leu Val Thr Gly Gln Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ala 
                805                 810                 815     


Ala Gly Leu Ser Glu Tyr Ser Gln Asp Ser Glu Ala Ile Glu Val Lys 
            820                 825                 830         


Ala Ala Ile Gly Gly Gly Val Ser Pro Asp Val Cys Pro Ala Leu Ser 
        835                 840                 845             


Asp Glu Pro Gly Gly Leu Thr Ala Ser Arg Gly Arg Val His Glu Ala 
    850                 855                 860                 


Ser Pro Pro Thr Phe Gln Lys Asp Ala Leu Leu Gly Ser Lys Pro Asn 
865                 870                 875                 880 


Lys Pro Ser Leu Pro Ser Ser Ser Gln Asn Leu Gly Gln Thr Glu Val 
                885                 890                 895     


Ser Lys Val Ser Glu Thr Val Gln Glu Glu Leu Thr Pro Pro Pro Gln 
            900                 905                 910         


Lys Ala Ala Pro Gln Gly Lys Ser Lys Ser Asp Pro Leu Lys Lys Lys 
        915                 920                 925             


Thr Asp Arg Ala Pro Pro Ser Pro Pro Cys Asp Ile Thr Cys Leu Glu 
    930                 935                 940                 


Ser Phe Arg Asp Ser Met Val Leu Gly Trp Lys Gln Pro Asp Lys Ile 
945                 950                 955                 960 


Gly Gly Ala Glu Ile Thr Gly Tyr Tyr Val Asn Tyr Arg Glu Val Ile 
                965                 970                 975     


Asp Gly Val Pro Gly Lys Trp Arg Glu Ala Asn Val Lys Ala Val Ser 
            980                 985                 990         


Glu Glu Ala Tyr Lys Ile Ser Asn  Leu Lys Glu Asn Met  Val Tyr Gln 
        995                 1000                 1005             


Phe Gln  Val Ala Ala Met Asn  Met Ala Gly Leu Gly  Ala Pro Ser 
    1010                 1015                 1020             


Ala Val  Ser Glu Cys Phe Lys  Cys Glu Glu Trp Thr  Ile Ala Val 
    1025                 1030                 1035             


Pro Gly  Pro Pro His Ser Leu  Lys Cys Ser Glu Val  Arg Lys Asp 
    1040                 1045                 1050             


Ser Leu  Val Leu Gln Trp Lys  Pro Pro Val His Ser  Gly Arg Thr 
    1055                 1060                 1065             


Pro Val  Thr Gly Tyr Phe Val  Asp Leu Lys Glu Ala  Lys Ala Lys 
    1070                 1075                 1080             


Glu Asp  Gln Trp Arg Gly Leu  Asn Glu Ala Ala Ile  Lys Asn Val 
    1085                 1090                 1095             


Tyr Leu  Lys Val Arg Gly Leu  Lys Glu Gly Val Ser  Tyr Val Phe 
    1100                 1105                 1110             


Arg Val  Arg Ala Ile Asn Gln  Ala Gly Val Gly Lys  Pro Ser Asp 
    1115                 1120                 1125             


Leu Ala  Gly Pro Val Val Ala  Glu Thr Arg Pro Gly  Thr Lys Glu 
    1130                 1135                 1140             


Val Val  Val Asn Val Asp Asp  Asp Gly Val Ile Ser  Leu Asn Phe 
    1145                 1150                 1155             


Glu Cys  Asp Lys Met Thr Pro  Lys Ser Glu Phe Ser  Trp Ser Lys 
    1160                 1165                 1170             


Asp Tyr  Val Ser Thr Glu Asp  Ser Pro Arg Leu Glu  Val Glu Ser 
    1175                 1180                 1185             


Lys Gly  Asn Lys Thr Lys Met  Thr Phe Lys Asp Leu  Gly Met Asp 
    1190                 1195                 1200             


Asp Leu  Gly Ile Tyr Ser Cys  Asp Val Thr Asp Thr  Asp Gly Ile 
    1205                 1210                 1215             


Ala Ser  Ser Tyr Leu Ile Asp  Glu Glu Glu Leu Lys  Arg Leu Leu 
    1220                 1225                 1230             


Ala Leu  Ser His Glu His Lys  Phe Pro Thr Val Pro  Val Lys Ser 
    1235                 1240                 1245             


Glu Leu  Ala Val Glu Ile Leu  Glu Lys Gly Gln Val  Arg Phe Trp 
    1250                 1255                 1260             


Met Gln  Ala Glu Lys Leu Ser  Gly Asn Ala Lys Val  Asn Tyr Ile 
    1265                 1270                 1275             


Phe Asn  Glu Lys Glu Ile Phe  Glu Gly Pro Lys Tyr  Lys Met His 
    1280                 1285                 1290             


Ile Asp  Arg Asn Thr Gly Ile  Ile Glu Met Phe Met  Glu Lys Leu 
    1295                 1300                 1305             


Gln Asp  Glu Asp Glu Gly Thr  Tyr Thr Phe Gln Leu  Gln Asp Gly 
    1310                 1315                 1320             


Lys Ala  Thr Asn His Ser Thr  Val Val Leu Val Gly  Asp Val Phe 
    1325                 1330                 1335             


Lys Lys  Leu Gln Lys Glu Ala  Glu Phe Gln Arg Gln  Glu Trp Ile 
    1340                 1345                 1350             


Arg Lys  Gln Gly Pro His Phe  Val Glu Tyr Leu Ser  Trp Glu Val 
    1355                 1360                 1365             


Thr Gly  Glu Cys Asn Val Leu  Leu Lys Cys Lys Val  Ala Asn Ile 
    1370                 1375                 1380             


Lys Lys  Glu Thr His Ile Val  Trp Tyr Lys Asp Glu  Arg Glu Ile 
    1385                 1390                 1395             


Ser Val  Asp Glu Lys His Asp  Phe Lys Asp Gly Ile  Cys Thr Leu 
    1400                 1405                 1410             


Leu Ile  Thr Glu Phe Ser Lys  Lys Asp Ala Gly Ile  Tyr Glu Val 
    1415                 1420                 1425             


Ile Leu  Lys Asp Asp Arg Gly  Lys Asp Lys Ser Arg  Leu Lys Leu 
    1430                 1435                 1440             


Val Asp  Glu Ala Phe Lys Glu  Leu Met Met Glu Val  Cys Lys Lys 
    1445                 1450                 1455             


Ile Ala  Leu Ser Ala Thr Asp  Leu Lys Ile Gln Ser  Thr Ala Glu 
    1460                 1465                 1470             


Gly Ile  Gln Leu Tyr Ser Phe  Val Thr Tyr Tyr Val  Glu Asp Leu 
    1475                 1480                 1485             


Lys Val  Asn Trp Ser His Asn  Gly Ser Ala Ile Arg  Tyr Ser Asp 
    1490                 1495                 1500             


Arg Val  Lys Thr Gly Val Thr  Gly Glu Gln Ile Trp  Leu Gln Ile 
    1505                 1510                 1515             


Asn Glu  Pro Thr Pro Asn Asp  Lys Gly Lys Tyr Val  Met Glu Leu 
    1520                 1525                 1530             


Phe Asp  Gly Lys Thr Gly His  Gln Lys Thr Val Asp  Leu Ser Gly 
    1535                 1540                 1545             


Gln Ala  Tyr Asp Glu Ala Tyr  Ala Glu Phe Gln Arg  Leu Lys Gln 
    1550                 1555                 1560             


Ala Ala  Ile Ala Glu Lys Asn  Arg Ala Arg Val Leu  Gly Gly Leu 
    1565                 1570                 1575             


Pro Asp  Val Val Thr Ile Gln  Glu Gly Lys Ala Leu  Asn Leu Thr 
    1580                 1585                 1590             


Cys Asn  Val Trp Gly Asp Pro  Pro Pro Glu Val Ser  Trp Leu Lys 
    1595                 1600                 1605             


Asn Glu  Lys Ala Leu Ala Ser  Asp Asp His Cys Asn  Leu Lys Phe 
    1610                 1615                 1620             


Glu Ala  Gly Arg Thr Ala Tyr  Phe Thr Ile Asn Gly  Val Ser Thr 
    1625                 1630                 1635             


Ala Asp  Ser Gly Lys Tyr Gly  Leu Val Val Lys Asn  Lys Tyr Gly 
    1640                 1645                 1650             


Ser Glu  Thr Ser Asp Phe Thr  Val Ser Val Phe Ile  Pro Glu Glu 
    1655                 1660                 1665             


Glu Ala  Arg Met Ala Ala Leu  Glu Ser Leu Lys Gly  Gly Lys Lys 
    1670                 1675                 1680             


Ala Lys  
    1685 


<210> 5902
<211> 1958
<212> PRT
<213> Homo sapiens

<400> 5902
Met Ala Asp Arg Thr Ala Pro Arg Cys Gln Leu Arg Leu Glu Trp Val 
1               5                   10                  15      


Tyr Gly Tyr Arg Gly His Gln Cys Arg Asn Asn Leu Tyr Tyr Thr Ala 
            20                  25                  30          


Gly Lys Glu Val Val Tyr Phe Val Ala Gly Val Gly Val Val Tyr Asn 
        35                  40                  45              


Thr Arg Glu His Ser Gln Lys Phe Phe Leu Gly His Asn Asp Asp Ile 
    50                  55                  60                  


Ile Ser Leu Ala Leu His Pro Asp Lys Thr Leu Val Ala Thr Gly Gln 
65                  70                  75                  80  


Val Gly Lys Glu Pro Tyr Ile Cys Ile Trp Asp Ser Tyr Asn Val Gln 
                85                  90                  95      


Thr Val Ser Leu Leu Lys Asp Val His Thr His Gly Val Ala Cys Leu 
            100                 105                 110         


Ala Phe Asp Ser Asp Gly Gln Arg Leu Ala Ser Val Gly Leu Asp Ala 
        115                 120                 125             


Lys Asn Thr Val Cys Ile Trp Asp Trp Arg Lys Gly Lys Leu Leu Ala 
    130                 135                 140                 


Ser Ala Thr Gly His Ser Asp Arg Ile Phe Asp Ile Ser Trp Asp Pro 
145                 150                 155                 160 


Tyr Gln Pro Asn Arg Val Val Ser Cys Gly Val Lys His Ile Lys Phe 
                165                 170                 175     


Trp Thr Leu Cys Gly Asn Ala Leu Thr Ala Lys Arg Gly Ile Phe Gly 
            180                 185                 190         


Lys Thr Gly Asp Leu Gln Thr Ile Leu Cys Leu Ala Cys Ala Lys Glu 
        195                 200                 205             


Asp Ile Thr Tyr Ser Gly Ala Leu Asn Gly Asp Ile Tyr Val Trp Lys 
    210                 215                 220                 


Gly Leu Asn Leu Val Arg Thr Ile Gln Gly Ala His Ser Ala Gly Ile 
225                 230                 235                 240 


Phe Ser Met Tyr Ala Cys Glu Glu Gly Phe Ala Thr Gly Gly Arg Asp 
                245                 250                 255     


Gly Cys Ile Arg Leu Trp Asp Thr Asp Phe Lys Pro Ile Thr Lys Ile 
            260                 265                 270         


Asp Leu Arg Glu Thr Glu Gln Gly Tyr Lys Gly Leu Ser Ile Arg Ser 
        275                 280                 285             


Val Cys Trp Lys Ala Asp Arg Leu Leu Ala Gly Thr Gln Asp Ser Glu 
    290                 295                 300                 


Ile Phe Glu Val Ile Val Arg Glu Arg Asp Lys Pro Met Leu Ile Leu 
305                 310                 315                 320 


Gln Gly His Cys Glu Gly Glu Leu Trp Ala Leu Ala Leu His Pro Lys 
                325                 330                 335     


Lys Pro Leu Ala Val Thr Gly Ser Asp Asp Arg Ser Val Arg Leu Trp 
            340                 345                 350         


Ser Leu Ala Asp His Ala Leu Ile Ala Arg Cys Asn Met Glu Glu Ala 
        355                 360                 365             


Val Arg Ser Val Ala Phe Ser Pro Asp Gly Ser Gln Leu Ala Leu Gly 
    370                 375                 380                 


Met Lys Asp Gly Ser Phe Ile Val Leu Arg Val Arg Asp Met Thr Glu 
385                 390                 395                 400 


Val Val His Ile Lys Asp Arg Lys Glu Val Ile His Glu Met Lys Phe 
                405                 410                 415     


Ser Pro Asp Gly Ser Tyr Leu Ala Val Gly Ser Asn Asp Gly Pro Val 
            420                 425                 430         


Asp Val Tyr Ala Val Ala Gln Arg Tyr Lys Lys Ile Gly Glu Cys Ser 
        435                 440                 445             


Lys Ser Leu Ser Phe Ile Thr His Ile Asp Trp Ser Leu Asp Ser Lys 
    450                 455                 460                 


Tyr Leu Gln Thr Asn Asp Gly Ala Gly Glu Arg Leu Phe Tyr Arg Met 
465                 470                 475                 480 


Pro Ser Gly Lys Pro Leu Thr Ser Lys Glu Glu Ile Lys Gly Ile Pro 
                485                 490                 495     


Trp Ala Ser Trp Thr Cys Val Lys Gly Pro Glu Val Ser Gly Ile Trp 
            500                 505                 510         


Pro Lys Tyr Thr Glu Val Thr Asp Ile Asn Ser Val Asp Ala Asn Tyr 
        515                 520                 525             


Asn Ser Ser Val Leu Val Ser Gly Asp Asp Phe Gly Leu Val Lys Leu 
    530                 535                 540                 


Phe Lys Phe Pro Cys Leu Lys Arg Gly Ala Lys Phe Arg Lys Tyr Val 
545                 550                 555                 560 


Gly His Ser Ala His Val Thr Asn Val Arg Trp Ser His Asp Phe Gln 
                565                 570                 575     


Trp Val Leu Ser Thr Gly Gly Ala Asp His Ser Val Phe Gln Trp Arg 
            580                 585                 590         


Phe Ile Pro Glu Gly Val Ser Asn Gly Met Leu Glu Thr Ala Pro Gln 
        595                 600                 605             


Glu Gly Gly Ala Asp Ser Tyr Ser Glu Glu Ser Asp Ser Asp Leu Ser 
    610                 615                 620                 


Asp Val Pro Glu Leu Asp Ser Asp Ile Glu Gln Glu Ala Gln Ile Asn 
625                 630                 635                 640 


Tyr Asp Arg Gln Val Tyr Lys Glu Asp Leu Pro Gln Leu Lys Gln Gln 
                645                 650                 655     


Ser Lys Glu Lys Asn His Ala Val Pro Phe Leu Lys Arg Glu Lys Ala 
            660                 665                 670         


Pro Glu Asp Ser Leu Lys Leu Gln Phe Ile His Gly Tyr Arg Gly Tyr 
        675                 680                 685             


Asp Cys Arg Asn Asn Leu Phe Tyr Thr Gln Ala Gly Glu Val Val Tyr 
    690                 695                 700                 


His Ile Ala Ala Val Ala Val Val Tyr Asn Arg Gln Gln His Ser Gln 
705                 710                 715                 720 


Arg Leu Tyr Leu Gly His Asp Asp Asp Ile Leu Ser Leu Thr Ile His 
                725                 730                 735     


Pro Val Lys Asp Tyr Val Ala Thr Gly Gln Val Gly Arg Asp Ala Ala 
            740                 745                 750         


Ile His Val Trp Asp Thr Gln Thr Leu Lys Cys Leu Ser Leu Leu Lys 
        755                 760                 765             


Gly Gln His Gln Arg Gly Val Cys Ala Leu Asp Phe Ser Ala Asp Gly 
    770                 775                 780                 


Lys Cys Leu Val Ser Val Gly Leu Asp Asp Phe His Ser Ile Val Phe 
785                 790                 795                 800 


Trp Asp Trp Lys Lys Gly Glu Lys Ile Ala Thr Thr Arg Gly His Lys 
                805                 810                 815     


Asp Lys Ile Phe Val Val Lys Cys Asn Pro His His Val Asp Lys Leu 
            820                 825                 830         


Val Thr Val Gly Ile Lys His Ile Lys Phe Trp Gln Gln Ala Gly Gly 
        835                 840                 845             


Gly Phe Thr Ser Lys Arg Gly Thr Phe Gly Ser Val Gly Lys Leu Glu 
    850                 855                 860                 


Thr Met Met Cys Val Ser Tyr Gly Arg Met Glu Asp Leu Val Phe Ser 
865                 870                 875                 880 


Gly Ala Ala Thr Gly Asp Ile Phe Ile Trp Lys Asp Ile Leu Leu Leu 
                885                 890                 895     


Lys Thr Val Lys Ala His Asp Gly Pro Val Phe Ala Met Tyr Ala Leu 
            900                 905                 910         


Asp Lys Gly Phe Val Thr Gly Gly Lys Asp Gly Ile Val Glu Leu Trp 
        915                 920                 925             


Asp Asp Met Phe Glu Arg Cys Leu Lys Thr Tyr Ala Ile Lys Arg Ser 
    930                 935                 940                 


Ala Leu Ser Thr Ser Ser Lys Gly Leu Leu Leu Glu Asp Asn Pro Ser 
945                 950                 955                 960 


Ile Arg Ala Ile Thr Leu Gly His Gly His Ile Leu Val Gly Thr Lys 
                965                 970                 975     


Asn Gly Glu Ile Leu Glu Ile Asp Lys Ser Gly Pro Met Thr Leu Leu 
            980                 985                 990         


Val Gln Gly His Met Glu Gly Glu  Val Trp Gly Leu Ala  Ala His Pro 
        995                 1000                 1005             


Leu Leu  Pro Ile Cys Ala Thr  Val Ser Asp Asp Lys  Thr Leu Arg 
    1010                 1015                 1020             


Ile Trp  Glu Leu Ser Ala Gln  His Arg Met Leu Ala  Val Arg Lys 
    1025                 1030                 1035             


Leu Lys  Lys Gly Gly Arg Cys  Cys Ala Phe Ser Pro  Asp Gly Lys 
    1040                 1045                 1050             


Ala Leu  Ala Val Gly Leu Asn  Asp Gly Ser Phe Leu  Val Val Asn 
    1055                 1060                 1065             


Ala Asp  Thr Val Glu Asp Met  Val Ser Phe His His  Arg Lys Glu 
    1070                 1075                 1080             


Met Ile  Ser Asp Ile Lys Phe  Ser Lys Asp Thr Gly  Lys Tyr Leu 
    1085                 1090                 1095             


Ala Val  Ala Ser His Asp Asn  Phe Val Asp Ile Tyr  Asn Val Leu 
    1100                 1105                 1110             


Thr Ser  Lys Arg Val Gly Ile  Cys Lys Gly Ala Ser  Ser Tyr Ile 
    1115                 1120                 1125             


Thr His  Ile Asp Trp Asp Ser  Arg Gly Lys Leu Leu  Gln Val Asn 
    1130                 1135                 1140             


Ser Gly  Ala Arg Glu Gln Leu  Phe Phe Glu Ala Pro  Arg Gly Lys 
    1145                 1150                 1155             


Arg His  Ile Ile Arg Pro Ser  Glu Ile Glu Lys Ile  Glu Trp Asp 
    1160                 1165                 1170             


Thr Trp  Thr Cys Val Leu Gly  Pro Thr Cys Glu Gly  Ile Trp Pro 
    1175                 1180                 1185             


Ala His  Ser Asp Ile Thr Asp  Val Asn Ala Ala Ser  Leu Thr Lys 
    1190                 1195                 1200             


Asp Cys  Ser Leu Leu Ala Thr  Gly Asp Asp Phe Gly  Phe Val Lys 
    1205                 1210                 1215             


Leu Phe  Ser Tyr Pro Val Lys  Gly Gln His Ala Arg  Phe Lys Lys 
    1220                 1225                 1230             


Tyr Val  Gly His Ser Ala His  Val Thr Asn Val Arg  Trp Leu His 
    1235                 1240                 1245             


Asn Asp  Ser Val Leu Leu Thr  Val Gly Gly Ala Asp  Thr Ala Leu 
    1250                 1255                 1260             


Met Ile  Trp Thr Arg Glu Phe  Val Gly Thr Gln Glu  Ser Lys Leu 
    1265                 1270                 1275             


Val Asp  Ser Glu Glu Ser Asp  Thr Asp Val Glu Glu  Asp Gly Gly 
    1280                 1285                 1290             


Tyr Asp  Ser Asp Val Ala Arg  Glu Lys Ala Ile Asp  Tyr Thr Thr 
    1295                 1300                 1305             


Lys Ile  Tyr Ala Val Ser Ile  Arg Glu Met Glu Gly  Thr Lys Pro 
    1310                 1315                 1320             


His Gln  Gln Leu Lys Glu Val  Ser Val Glu Glu Arg  Pro Pro Val 
    1325                 1330                 1335             


Ser Arg  Ala Ala Pro Gln Pro  Glu Lys Leu Gln Lys  Asn Asn Ile 
    1340                 1345                 1350             


Thr Lys  Lys Lys Lys Leu Val  Glu Glu Leu Ala Leu  Asp His Val 
    1355                 1360                 1365             


Phe Gly  Tyr Arg Gly Phe Asp  Cys Arg Asn Asn Leu  His Tyr Leu 
    1370                 1375                 1380             


Asn Asp  Gly Ala Asp Ile Ile  Phe His Thr Ala Ala  Ala Gly Ile 
    1385                 1390                 1395             


Val Gln  Asn Leu Ser Thr Gly  Ser Gln Ser Phe Tyr  Leu Glu His 
    1400                 1405                 1410             


Thr Asp  Asp Ile Leu Cys Leu  Thr Val Asn Gln His  Pro Lys Tyr 
    1415                 1420                 1425             


Arg Asn  Val Val Ala Thr Ser  Gln Ile Gly Thr Thr  Pro Ser Ile 
    1430                 1435                 1440             


His Ile  Trp Asp Ala Met Thr  Lys His Thr Leu Ser  Met Leu Arg 
    1445                 1450                 1455             


Cys Phe  His Ser Lys Gly Val  Asn Tyr Ile Asn Phe  Ser Ala Thr 
    1460                 1465                 1470             


Gly Lys  Leu Leu Val Ser Val  Gly Val Asp Pro Glu  His Thr Ile 
    1475                 1480                 1485             


Thr Val  Trp Arg Trp Gln Glu  Gly Ala Lys Val Ala  Ser Arg Gly 
    1490                 1495                 1500             


Gly His  Leu Glu Arg Ile Phe  Val Val Glu Phe Arg  Pro Asp Ser 
    1505                 1510                 1515             


Asp Thr  Gln Phe Val Ser Val  Gly Val Lys His Met  Lys Phe Trp 
    1520                 1525                 1530             


Thr Leu  Ala Gly Ser Ala Leu  Leu Tyr Lys Lys Gly  Val Ile Gly 
    1535                 1540                 1545             


Ser Leu  Gly Ala Ala Lys Met  Gln Thr Met Leu Ser  Val Ala Phe 
    1550                 1555                 1560             


Gly Ala  Asn Asn Leu Thr Phe  Thr Gly Ala Ile Asn  Gly Asp Val 
    1565                 1570                 1575             


Tyr Val  Trp Lys Asp His Phe  Leu Ile Arg Leu Val  Ala Lys Ala 
    1580                 1585                 1590             


His Thr  Gly Pro Val Phe Thr  Met Tyr Thr Thr Leu  Arg Asp Gly 
    1595                 1600                 1605             


Leu Ile  Val Thr Gly Gly Lys  Glu Arg Pro Thr Lys  Glu Gly Gly 
    1610                 1615                 1620             


Ala Val  Lys Leu Trp Asp Gln  Glu Met Lys Arg Cys  Arg Ala Phe 
    1625                 1630                 1635             


Gln Leu  Glu Thr Gly Gln Leu  Val Glu Cys Val Arg  Ser Val Cys 
    1640                 1645                 1650             


Arg Gly  Lys Gly Lys Ile Leu  Val Gly Thr Lys Asp  Gly Glu Ile 
    1655                 1660                 1665             


Ile Glu  Val Gly Glu Lys Asn  Ala Ala Ser Asn Ile  Leu Ile Asp 
    1670                 1675                 1680             


Gly His  Met Glu Gly Glu Ile  Trp Gly Leu Ala Thr  His Pro Ser 
    1685                 1690                 1695             


Lys Asp  Leu Phe Ile Ser Ala  Ser Asn Asp Gly Thr  Ala Arg Ile 
    1700                 1705                 1710             


Trp Asp  Leu Ala Asp Lys Lys  Leu Leu Asn Lys Val  Ser Leu Gly 
    1715                 1720                 1725             


His Ala  Ala Arg Cys Ala Ala  Tyr Ser Pro Asp Gly  Glu Met Val 
    1730                 1735                 1740             


Ala Ile  Gly Met Lys Asn Gly  Glu Phe Val Ile Leu  Leu Val Asn 
    1745                 1750                 1755             


Ser Leu  Lys Val Trp Gly Lys  Lys Arg Asp Arg Lys  Ser Ala Ile 
    1760                 1765                 1770             


Gln Asp  Ile Arg Ile Ser Pro  Asp Asn Arg Phe Leu  Ala Val Gly 
    1775                 1780                 1785             


Ser Ser  Glu His Thr Val Asp  Phe Tyr Asp Leu Thr  Gln Gly Thr 
    1790                 1795                 1800             


Asn Leu  Asn Arg Ile Gly Tyr  Cys Lys Asp Ile Pro  Ser Phe Val 
    1805                 1810                 1815             


Ile Gln  Met Asp Phe Ser Ala  Asp Gly Lys Tyr Ile  Gln Val Ser 
    1820                 1825                 1830             


Thr Gly  Ala Tyr Lys Arg Gln  Val His Glu Val Pro  Leu Gly Lys 
    1835                 1840                 1845             


Gln Val  Thr Glu Ala Val Val  Ile Glu Lys Ile Thr  Trp Ala Ser 
    1850                 1855                 1860             


Trp Thr  Ser Val Leu Gly Asp  Glu Val Ile Gly Ile  Trp Pro Arg 
    1865                 1870                 1875             


Asn Ala  Asp Lys Ala Asp Val  Asn Cys Ala Cys Val  Thr His Ala 
    1880                 1885                 1890             


Gly Leu  Asn Ile Val Thr Gly  Asp Asp Phe Gly Leu  Val Lys Leu 
    1895                 1900                 1905             


Phe Asp  Phe Pro Cys Thr Glu  Lys Phe Ala Lys His  Lys Arg Tyr 
    1910                 1915                 1920             


Phe Gly  His Ser Ala His Val  Thr Asn Ile Arg Phe  Ser Tyr Asp 
    1925                 1930                 1935             


Asp Lys  Tyr Val Val Ser Thr  Gly Gly Asp Asp Cys  Ser Val Phe 
    1940                 1945                 1950             


Val Trp  Arg Cys Leu 
    1955             


<210> 5903
<211> 209
<212> PRT
<213> Homo sapiens

<400> 5903
Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 
65                  70                  75                  80  


Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 
                85                  90                  95      


Gln Tyr Trp Lys Glu Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu 
            100                 105                 110         


Ala Leu Lys Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp 
        115                 120                 125             


Asn Glu Ile Ala Arg Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val 
    130                 135                 140                 


Ala Glu His Val Gln Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly 
145                 150                 155                 160 


Glu Pro Leu Asp Asn Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser 
                165                 170                 175     


Glu Glu Glu Thr Val Glu Asp Ser Leu Val Glu Asp Ser Glu Ile Gly 
            180                 185                 190         


Thr Cys Ala Glu Gly Thr Val Ser Ser Ser Thr Asp Ala Lys Pro Cys 
        195                 200                 205             


Ile 
    


<210> 5904
<211> 544
<212> PRT
<213> Homo sapiens

<400> 5904
Met Asn Thr Ser Ile Pro Tyr Gln Gln Asn Pro Tyr Asn Pro Arg Gly 
1               5                   10                  15      


Ser Ser Asn Val Ile Gln Cys Tyr Arg Cys Gly Asp Thr Cys Lys Gly 
            20                  25                  30          


Glu Val Val Arg Val His Asn Asn His Phe His Ile Arg Cys Phe Thr 
        35                  40                  45              


Cys Gln Val Cys Gly Cys Gly Leu Ala Gln Ser Gly Phe Phe Phe Lys 
    50                  55                  60                  


Asn Gln Glu Tyr Ile Cys Thr Gln Asp Tyr Gln Gln Leu Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys Asp Ser Cys Arg Asp Phe Ile Thr Gly Glu Val Ile Ser Ala 
                85                  90                  95      


Leu Gly Arg Thr Tyr His Pro Lys Cys Phe Val Cys Ser Leu Cys Arg 
            100                 105                 110         


Lys Pro Phe Pro Ile Gly Asp Lys Val Thr Phe Ser Gly Lys Glu Cys 
        115                 120                 125             


Val Cys Gln Thr Cys Ser Gln Ser Met Ala Ser Ser Lys Pro Ile Lys 
    130                 135                 140                 


Ile Arg Gly Pro Ser His Cys Ala Gly Cys Lys Glu Glu Ile Lys His 
145                 150                 155                 160 


Gly Gln Ser Leu Leu Ala Leu Asp Lys Gln Trp His Val Ser Cys Phe 
                165                 170                 175     


Lys Cys Gln Thr Cys Ser Val Ile Leu Thr Gly Glu Tyr Ile Ser Lys 
            180                 185                 190         


Asp Gly Val Pro Tyr Cys Glu Ser Asp Tyr His Ala Gln Phe Gly Ile 
        195                 200                 205             


Lys Cys Glu Thr Cys Asp Arg Tyr Ile Ser Gly Arg Val Leu Glu Ala 
    210                 215                 220                 


Gly Gly Lys His Tyr His Pro Thr Cys Ala Arg Cys Val Arg Cys His 
225                 230                 235                 240 


Gln Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Thr Gly Ser Glu Val 
                245                 250                 255     


Trp His Pro Ile Cys Lys Gln Ala Ala Arg Ala Glu Lys Lys Leu Lys 
            260                 265                 270         


His Arg Arg Thr Ser Glu Thr Ser Ile Ser Pro Pro Gly Ser Ser Ile 
        275                 280                 285             


Gly Ser Pro Asn Arg Val Ile Cys Asp Ile Tyr Glu Asn Leu Asp Leu 
    290                 295                 300                 


Arg Gln Arg Arg Ala Ser Ser Pro Gly Tyr Ile Asp Ser Pro Thr Tyr 
305                 310                 315                 320 


Ser Arg Gln Gly Met Ser Pro Thr Phe Ser Arg Ser Pro His His Tyr 
                325                 330                 335     


Tyr Arg Ser Gly Asp Leu Ser Thr Ala Thr Lys Ser Lys Thr Ser Glu 
            340                 345                 350         


Asp Ile Ser Gln Thr Ser Lys Tyr Ser Pro Ile Tyr Ser Pro Asp Pro 
        355                 360                 365             


Tyr Tyr Ala Ser Glu Ser Glu Tyr Trp Thr Tyr His Gly Ser Pro Lys 
    370                 375                 380                 


Val Pro Arg Ala Arg Arg Phe Ser Ser Gly Gly Glu Glu Asp Asp Phe 
385                 390                 395                 400 


Asp Arg Ser Met His Lys Leu Gln Ser Gly Ile Gly Arg Leu Ile Leu 
                405                 410                 415     


Lys Glu Glu Met Lys Ala Arg Ser Ser Ser Tyr Ala Asp Pro Trp Thr 
            420                 425                 430         


Pro Pro Arg Ser Ser Thr Ser Ser Arg Glu Ala Leu His Thr Ala Gly 
        435                 440                 445             


Tyr Glu Met Ser Leu Asn Gly Ser Pro Arg Ser His Tyr Leu Ala Asp 
    450                 455                 460                 


Ser Asp Pro Leu Ile Ser Lys Ser Ala Ser Leu Pro Ala Tyr Arg Arg 
465                 470                 475                 480 


Asn Gly Leu His Arg Thr Pro Ser Ala Asp Leu Phe His Tyr Asp Ser 
                485                 490                 495     


Met Asn Ala Val Asn Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr 
            500                 505                 510         


Glu Leu Leu Leu Val Thr Thr Arg Gly Arg Asn Arg Leu Pro Lys Asp 
        515                 520                 525             


Val Asp Arg Thr Arg Leu Glu Gly Asn Phe Trp Lys Ser Gly Cys Leu 
    530                 535                 540                 


<210> 5905
<211> 279
<212> PRT
<213> Homo sapiens

<400> 5905
Met Thr Pro Ser Glu Gly Ala Arg Ala Gly Thr Gly Arg Glu Leu Glu 
1               5                   10                  15      


Met Leu Asp Ser Leu Leu Ala Leu Gly Gly Leu Val Leu Leu Arg Asp 
            20                  25                  30          


Ser Val Glu Trp Glu Gly Arg Ser Leu Leu Lys Ala Leu Val Lys Lys 
        35                  40                  45              


Ser Ala Leu Cys Gly Glu Gln Val His Ile Leu Gly Cys Glu Val Ser 
    50                  55                  60                  


Glu Glu Glu Phe Arg Glu Gly Phe Asp Ser Asp Ile Asn Asn Arg Leu 
65                  70                  75                  80  


Val Tyr His Asp Phe Phe Arg Asp Pro Leu Asn Trp Ser Lys Thr Glu 
                85                  90                  95      


Glu Ala Phe Pro Gly Gly Pro Leu Gly Ala Leu Arg Ala Met Cys Lys 
            100                 105                 110         


Arg Thr Asp Pro Val Pro Val Thr Ile Ala Leu Asp Ser Leu Ser Trp 
        115                 120                 125             


Leu Leu Leu Arg Leu Pro Cys Thr Thr Leu Cys Gln Val Leu His Ala 
    130                 135                 140                 


Val Ser His Gln Asp Ser Cys Pro Gly Asp Ser Ser Ser Val Gly Lys 
145                 150                 155                 160 


Val Ser Val Leu Gly Leu Leu His Glu Glu Leu His Gly Pro Gly Pro 
                165                 170                 175     


Val Gly Ala Leu Ser Ser Leu Ala Gln Thr Glu Val Thr Leu Gly Gly 
            180                 185                 190         


Thr Met Gly Gln Ala Ser Ala His Ile Leu Cys Arg Arg Pro Arg Gln 
        195                 200                 205             


Arg Pro Thr Asp Gln Thr Gln Trp Phe Ser Ile Leu Pro Asp Phe Ser 
    210                 215                 220                 


Leu Asp Leu Gln Glu Gly Pro Ser Val Glu Ser Gln Pro Tyr Ser Asp 
225                 230                 235                 240 


Pro His Ile Pro Pro Val Ser Lys Asn Ala Lys Ala Arg Thr Arg Lys 
                245                 250                 255     


Cys Ser Leu Val Ser Gly His Gly Arg Glu Asn Lys Ser Cys Arg Gly 
            260                 265                 270         


Trp Gly Trp Gly Gln Gly Phe 
        275                 


<210> 5906
<211> 134
<212> PRT
<213> Homo sapiens

<400> 5906
Met Ser Glu Asn Ala Ala Pro Gly Leu Cys Gly Glu Leu Leu Leu Gln 
1               5                   10                  15      


Arg Gly Thr Thr Lys Val Ala Thr Gly Leu Val Leu Asn Arg Asp Gln 
            20                  25                  30          


Arg Leu Ala Trp Ala Glu Asn Ser Ile Asp Phe Ile Ser Arg Glu Leu 
        35                  40                  45              


Cys Ala His Ser Ile Arg Lys Leu Gln Ala His Val Leu Leu Ile Lys 
    50                  55                  60                  


Ala Val His Gly Tyr Phe Asp Ser Arg Gln Asn Tyr Ser Glu Lys Glu 
65                  70                  75                  80  


Ser Leu Ser Phe Met Ile Asp Thr Met Lys Ser Thr Leu Lys Glu Gln 
                85                  90                  95      


Phe Gln Phe Val Glu Val Pro Gly Asn His Cys Val His Met Ser Glu 
            100                 105                 110         


Pro Gln His Val Ala Ser Ile Ile Ser Ser Phe Leu Gln Cys Thr His 
        115                 120                 125             


Met Leu Pro Ala Gln Leu 
    130                 


<210> 5907
<211> 449
<212> PRT
<213> Homo sapiens

<400> 5907
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210> 5908
<211> 1358
<212> PRT
<213> Homo sapiens

<400> 5908
Met Gly Asn Gln Leu Ala Gly Ile Ala Pro Ser Gln Ile Leu Ser Val 
1               5                   10                  15      


Glu Ser Tyr Phe Ser Asp Ile His Asp Phe Glu Tyr Asp Lys Ser Leu 
            20                  25                  30          


Gly Ser Thr Arg Phe Phe Lys Val Ala Arg Ala Lys His Arg Glu Gly 
        35                  40                  45              


Leu Val Val Val Lys Val Phe Ala Ile Gln Asp Pro Thr Leu Pro Leu 
    50                  55                  60                  


Thr Ser Tyr Lys Gln Glu Leu Glu Glu Leu Lys Ile Arg Leu Asn Ser 
65                  70                  75                  80  


Ala Gln Asn Cys Leu Pro Phe Gln Lys Ala Ser Glu Lys Ala Ser Glu 
                85                  90                  95      


Lys Ala Ala Met Leu Phe Arg Gln Tyr Val Arg Asp Asn Leu Tyr Asp 
            100                 105                 110         


Arg Ile Ser Thr Arg Pro Phe Leu Asn Asn Ile Glu Lys Arg Trp Ile 
        115                 120                 125             


Ala Phe Gln Ile Leu Thr Ala Val Asp Gln Ala His Lys Ser Gly Val 
    130                 135                 140                 


Arg His Gly Asp Ile Lys Thr Glu Asn Val Met Val Thr Ser Trp Asn 
145                 150                 155                 160 


Trp Val Leu Leu Thr Asp Phe Ala Ser Phe Lys Pro Thr Tyr Leu Pro 
                165                 170                 175     


Glu Asp Asn Pro Ala Asp Phe Asn Tyr Phe Phe Asp Thr Ser Arg Arg 
            180                 185                 190         


Arg Thr Cys Tyr Ile Ala Pro Glu Arg Phe Val Asp Gly Gly Met Phe 
        195                 200                 205             


Ala Thr Glu Leu Glu Tyr Met Arg Asp Pro Ser Thr Pro Leu Val Asp 
    210                 215                 220                 


Leu Asn Ser Asn Gln Arg Thr Arg Gly Glu Leu Lys Arg Ala Met Asp 
225                 230                 235                 240 


Ile Phe Ser Ala Gly Cys Val Ile Ala Glu Leu Phe Thr Glu Gly Val 
                245                 250                 255     


Pro Leu Phe Asp Leu Ser Gln Leu Leu Ala Tyr Arg Asn Gly His Phe 
            260                 265                 270         


Phe Pro Glu Gln Val Leu Asn Lys Ile Glu Asp His Ser Ile Arg Glu 
        275                 280                 285             


Leu Val Thr Gln Met Ile His Arg Glu Pro Asp Lys Arg Leu Glu Ala 
    290                 295                 300                 


Glu Asp Tyr Leu Lys Gln Gln Arg Gly Asn Ala Phe Pro Glu Ile Phe 
305                 310                 315                 320 


Tyr Thr Phe Leu Gln Pro Tyr Met Ala Gln Phe Ala Lys Glu Thr Phe 
                325                 330                 335     


Leu Ser Ala Asp Glu Arg Ile Leu Val Ile Arg Lys Asp Leu Gly Asn 
            340                 345                 350         


Ile Ile His Asn Leu Cys Gly His Asp Leu Pro Glu Lys Ala Glu Gly 
        355                 360                 365             


Glu Pro Lys Glu Asn Gly Leu Val Ile Leu Val Ser Val Ile Thr Ser 
    370                 375                 380                 


Cys Leu Gln Thr Leu Lys Tyr Cys Asp Ser Lys Leu Ala Ala Leu Glu 
385                 390                 395                 400 


Leu Ile Leu His Leu Ala Pro Arg Leu Ser Val Glu Ile Leu Leu Asp 
                405                 410                 415     


Arg Ile Thr Pro Tyr Leu Leu His Phe Ser Asn Asp Ser Val Pro Arg 
            420                 425                 430         


Val Arg Ala Glu Ala Leu Arg Thr Leu Thr Lys Val Leu Ala Leu Val 
        435                 440                 445             


Lys Glu Val Pro Arg Asn Asp Ile Asn Ile Tyr Pro Glu Tyr Ile Leu 
    450                 455                 460                 


Pro Gly Ile Ala His Leu Ala Gln Asp Asp Ala Thr Ile Val Arg Leu 
465                 470                 475                 480 


Ala Tyr Ala Glu Asn Ile Ala Leu Leu Ala Glu Thr Ala Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Val Gln Leu Lys Asn Leu Asn Met Glu Asn Asp Pro Asn 
            500                 505                 510         


Asn Glu Glu Ile Asp Glu Val Thr His Pro Asn Gly Asn Tyr Asp Thr 
        515                 520                 525             


Glu Leu Gln Ala Leu His Glu Met Val Gln Gln Lys Val Val Thr Leu 
    530                 535                 540                 


Leu Ser Asp Pro Glu Asn Ile Val Lys Gln Thr Leu Met Glu Asn Gly 
545                 550                 555                 560 


Ile Thr Arg Leu Cys Val Phe Phe Gly Arg Gln Lys Ala Asn Asp Val 
                565                 570                 575     


Leu Leu Ser His Met Ile Thr Phe Leu Asn Asp Lys Asn Asp Trp His 
            580                 585                 590         


Leu Arg Gly Ala Phe Phe Asp Ser Ile Val Gly Val Ala Ala Tyr Val 
        595                 600                 605             


Gly Trp Gln Ser Ser Ser Ile Leu Lys Pro Leu Leu Gln Gln Gly Leu 
    610                 615                 620                 


Ser Asp Ala Glu Glu Phe Val Ile Val Lys Ala Leu Tyr Ala Leu Thr 
625                 630                 635                 640 


Cys Met Cys Gln Leu Gly Leu Leu Gln Lys Pro His Val Tyr Glu Phe 
                645                 650                 655     


Ala Ser Asp Ile Ala Pro Phe Leu Cys His Pro Asn Leu Trp Ile Arg 
            660                 665                 670         


Tyr Gly Ala Val Gly Phe Ile Thr Val Val Ala Arg Gln Ile Ser Thr 
        675                 680                 685             


Ala Asp Val Tyr Cys Lys Leu Met Pro Tyr Leu Asp Pro Tyr Ile Thr 
    690                 695                 700                 


Gln Pro Ile Ile Gln Ile Glu Arg Lys Leu Val Leu Leu Ser Val Leu 
705                 710                 715                 720 


Lys Glu Pro Val Ser Arg Ser Ile Phe Asp Tyr Ala Leu Arg Ser Lys 
                725                 730                 735     


Asp Ile Thr Ser Leu Phe Arg His Leu His Met Arg Gln Lys Lys Arg 
            740                 745                 750         


Asn Gly Ser Leu Pro Asp Cys Pro Pro Pro Glu Asp Pro Ala Ile Ala 
        755                 760                 765             


Gln Leu Leu Lys Lys Leu Leu Ser Gln Gly Met Thr Glu Glu Glu Glu 
    770                 775                 780                 


Asp Lys Leu Leu Ala Leu Lys Asp Phe Met Met Lys Ser Asn Lys Ala 
785                 790                 795                 800 


Lys Ala Asn Ile Val Asp Gln Ser His Leu His Asp Ser Ser Gln Lys 
                805                 810                 815     


Gly Val Ile Asp Leu Ala Ala Leu Gly Ile Thr Gly Arg Gln Val Asp 
            820                 825                 830         


Leu Val Lys Thr Lys Gln Glu Pro Asp Asp Lys Arg Ala Arg Lys His 
        835                 840                 845             


Val Lys Gln Asp Ser Asn Val Asn Glu Glu Trp Lys Ser Met Phe Gly 
    850                 855                 860                 


Ser Leu Asp Pro Pro Asn Met Pro Gln Ala Leu Pro Lys Gly Ser Asp 
865                 870                 875                 880 


Gln Glu Val Ile Gln Thr Gly Lys Pro Pro Arg Ser Glu Ser Ser Ala 
                885                 890                 895     


Gly Ile Cys Val Pro Leu Ser Thr Ser Ser Gln Val Pro Glu Val Thr 
            900                 905                 910         


Thr Val Gln Asn Lys Lys Pro Val Ile Pro Val Leu Ser Ser Thr Ile 
        915                 920                 925             


Leu Pro Ser Thr Tyr Gln Ile Arg Ile Thr Thr Cys Lys Thr Glu Leu 
    930                 935                 940                 


Gln Gln Leu Ile Gln Gln Lys Arg Glu Gln Cys Asn Ala Glu Arg Ile 
945                 950                 955                 960 


Ala Lys Gln Met Met Glu Asn Ala Glu Trp Glu Ser Lys Pro Pro Pro 
                965                 970                 975     


Pro Gly Trp Arg Pro Lys Gly Leu Leu Val Ala His Leu His Glu His 
            980                 985                 990         


Lys Ser Ala Val Asn Arg Ile Arg  Val Ser Asp Glu His  Ser Leu Phe 
        995                 1000                 1005             


Ala Thr  Cys Ser Asn Asp Gly  Thr Val Lys Ile Trp  Asn Ser Gln 
    1010                 1015                 1020             


Lys Met  Glu Gly Lys Thr Thr  Thr Thr Arg Ser Ile  Leu Thr Tyr 
    1025                 1030                 1035             


Ser Arg  Ile Gly Gly Arg Val  Lys Thr Leu Thr Phe  Cys Gln Gly 
    1040                 1045                 1050             


Ser His  Tyr Leu Ala Ile Ala  Ser Asp Asn Gly Ala  Val Gln Leu 
    1055                 1060                 1065             


Leu Gly  Ile Glu Ala Ser Lys  Leu Pro Lys Ser Pro  Lys Ile His 
    1070                 1075                 1080             


Pro Leu  Gln Ser Arg Ile Leu  Asp Gln Lys Glu Asp  Gly Cys Val 
    1085                 1090                 1095             


Val Asp  Met His His Phe Asn  Ser Gly Ala Gln Ser  Val Leu Ala 
    1100                 1105                 1110             


Tyr Ala  Thr Val Asn Gly Ser  Leu Val Gly Trp Asp  Leu Arg Ser 
    1115                 1120                 1125             


Ser Ser  Asn Ala Trp Thr Leu  Lys His Asp Leu Lys  Ser Gly Leu 
    1130                 1135                 1140             


Ile Thr  Ser Phe Ala Val Asp  Ile His Gln Cys Trp  Leu Cys Ile 
    1145                 1150                 1155             


Gly Thr  Ser Ser Gly Thr Met  Ala Cys Trp Asp Met  Arg Phe Gln 
    1160                 1165                 1170             


Leu Pro  Ile Ser Ser His Cys  His Pro Ser Arg Ala  Arg Ile Arg 
    1175                 1180                 1185             


Arg Leu  Ser Met His Pro Leu  Tyr Gln Ser Trp Val  Ile Ala Ala 
    1190                 1195                 1200             


Val Gln  Gly Asn Asn Glu Val  Ser Met Trp Asp Met  Glu Thr Gly 
    1205                 1210                 1215             


Asp Arg  Arg Phe Thr Leu Trp  Ala Ser Ser Ala Pro  Pro Leu Ser 
    1220                 1225                 1230             


Glu Leu  Gln Pro Ser Pro His  Ser Val His Gly Ile  Tyr Cys Ser 
    1235                 1240                 1245             


Pro Ala  Asp Gly Asn Pro Ile  Leu Leu Thr Ala Gly  Ser Asp Met 
    1250                 1255                 1260             


Lys Ile  Arg Phe Trp Asp Leu  Ala Tyr Pro Glu Arg  Ser Tyr Val 
    1265                 1270                 1275             


Val Ala  Gly Ser Thr Ser Ser  Pro Ser Val Ser Tyr  Tyr Arg Lys 
    1280                 1285                 1290             


Ile Ile  Glu Gly Thr Glu Val  Val Gln Glu Ile Gln  Asn Lys Gln 
    1295                 1300                 1305             


Lys Val  Gly Pro Ser Asp Asp  Thr Pro Arg Arg Gly  Pro Glu Ser 
    1310                 1315                 1320             


Leu Pro  Val Gly His His Asp  Ile Ile Thr Asp Val  Ala Thr Phe 
    1325                 1330                 1335             


Gln Thr  Thr Gln Gly Phe Ile  Val Thr Ala Ser Arg  Asp Gly Ile 
    1340                 1345                 1350             


Val Lys  Val Trp Lys 
    1355             


<210> 5909
<211> 330
<212> PRT
<213> Homo sapiens

<400> 5909
Met Pro Val Val Thr Thr Asp Ala Glu Ser Glu Thr Gly Ile Pro Lys 
1               5                   10                  15      


Ser Leu Ser Asn Glu Pro Pro Ser Glu Thr Met Glu Glu Ile Glu His 
            20                  25                  30          


Thr Cys Pro Gln Pro Arg Leu Thr Leu Thr Ala Pro Ala Pro Phe Ala 
        35                  40                  45              


Asp Glu Thr Asn Cys Gln Cys Gln Ala Pro His Glu Lys Leu Thr Ile 
    50                  55                  60                  


Ala Gln Ala Arg Leu Gly Thr Pro Ala Asp Arg Pro Val Arg Val Tyr 
65                  70                  75                  80  


Ala Asp Gly Ile Phe Asp Leu Phe His Ser Gly His Ala Arg Ala Leu 
                85                  90                  95      


Met Gln Ala Lys Thr Leu Phe Pro Asn Ser Tyr Leu Leu Val Gly Val 
            100                 105                 110         


Cys Ser Asp Asp Leu Thr His Lys Phe Lys Gly Phe Thr Val Met Asn 
        115                 120                 125             


Glu Ala Glu Arg Tyr Glu Ala Leu Arg His Cys Arg Tyr Val Asp Glu 
    130                 135                 140                 


Val Ile Arg Asp Ala Pro Trp Thr Leu Thr Pro Glu Phe Leu Glu Lys 
145                 150                 155                 160 


His Lys Ile Asp Phe Val Ala His Asp Asp Ile Pro Tyr Ser Ser Ala 
                165                 170                 175     


Gly Ser Asp Asp Val Tyr Lys His Ile Lys Glu Ala Gly Met Phe Val 
            180                 185                 190         


Pro Thr Gln Arg Thr Glu Gly Ile Ser Thr Ser Asp Ile Ile Thr Arg 
        195                 200                 205             


Ile Val Arg Asp Tyr Asp Val Tyr Ala Arg Arg Asn Leu Gln Arg Gly 
    210                 215                 220                 


Tyr Thr Ala Lys Glu Leu Asn Val Ser Phe Ile Asn Glu Lys Arg Tyr 
225                 230                 235                 240 


Arg Phe Gln Asn Gln Val Asp Lys Met Lys Glu Lys Val Lys Asn Val 
                245                 250                 255     


Glu Glu Arg Ser Lys Glu Phe Val Asn Arg Val Glu Glu Lys Ser His 
            260                 265                 270         


Asp Leu Ile Gln Lys Trp Glu Glu Lys Ser Arg Glu Phe Ile Gly Asn 
        275                 280                 285             


Phe Leu Glu Leu Phe Gly Pro Asp Gly Ala Trp Lys Gln Met Phe Gln 
    290                 295                 300                 


Glu Arg Ser Ser Arg Met Leu Gln Ala Leu Ser Pro Lys Gln Ser Pro 
305                 310                 315                 320 


Leu Lys Ser Trp Ala Arg Cys Arg Asp Phe 
                325                 330 


<210> 5910
<211> 674
<212> PRT
<213> Homo sapiens

<400> 5910
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met 
            100                 105                 110         


Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser 
        115                 120                 125             


Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr 
    130                 135                 140                 


Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser 
145                 150                 155                 160 


Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe 
                165                 170                 175     


Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met 
            180                 185                 190         


Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly 
        195                 200                 205             


Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val 
    210                 215                 220                 


Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val 
225                 230                 235                 240 


Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln 
                245                 250                 255     


Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro 
            260                 265                 270         


Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu 
        275                 280                 285             


Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val 
    290                 295                 300                 


Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser 
305                 310                 315                 320 


Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile 
                325                 330                 335     


Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln 
            340                 345                 350         


Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro 
        355                 360                 365             


Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile 
    370                 375                 380                 


Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp 
385                 390                 395                 400 


Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile 
                405                 410                 415     


Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly 
            420                 425                 430         


Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser 
    450                 455                 460                 


Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys 
465                 470                 475                 480 


Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val 
                485                 490                 495     


Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly 
            500                 505                 510         


Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu 
        515                 520                 525             


Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala 
    530                 535                 540                 


Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val 
545                 550                 555                 560 


Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile 
                565                 570                 575     


Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu 
            580                 585                 590         


Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met 
        595                 600                 605             


Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln 
    610                 615                 620                 


Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala 
625                 630                 635                 640 


Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser 
                645                 650                 655     


Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys 
            660                 665                 670         


Gly Lys 
        


<210> 5911
<211> 380
<212> PRT
<213> Homo sapiens

<400> 5911
Met Leu Arg Arg Lys Pro Ser Asn Ala Ser Glu Lys Glu Pro Thr Gln 
1               5                   10                  15      


Lys Lys Lys Leu Ser Leu Gln Arg Ser Ser Ser Phe Lys Asp Phe Ala 
            20                  25                  30          


Lys Ser Lys Pro Ser Ser Pro Val Val Ser Glu Lys Glu Phe Asn Leu 
        35                  40                  45              


Asp Asp Asn Ile Pro Glu Asp Asp Ser Gly Val Pro Thr Pro Glu Asp 
    50                  55                  60                  


Ala Gly Lys Ser Gly Lys Lys Leu Gly Lys Lys Trp Arg Ala Val Ile 
65                  70                  75                  80  


Ser Arg Thr Met Asn Arg Lys Met Gly Lys Met Met Val Lys Ala Leu 
                85                  90                  95      


Ser Glu Glu Met Ala Asp Thr Leu Glu Glu Gly Ser Ala Ser Pro Thr 
            100                 105                 110         


Ser Pro Asp Tyr Ser Leu Asp Ser Pro Gly Pro Glu Lys Met Ala Leu 
        115                 120                 125             


Ala Phe Ser Glu Gln Glu Glu His Glu Leu Pro Val Leu Ser Arg Gln 
    130                 135                 140                 


Ala Ser Thr Gly Ser Glu Leu Cys Ser Pro Ser Pro Gly Ser Gly Ser 
145                 150                 155                 160 


Phe Gly Glu Glu Pro Pro Ala Pro Gln Tyr Thr Gly Pro Phe Cys Gly 
                165                 170                 175     


Arg Ala Arg Val His Thr Asp Phe Thr Pro Ser Pro Tyr Asp His Asp 
            180                 185                 190         


Ser Leu Lys Leu Gln Lys Gly Asp Val Ile Gln Ile Ile Glu Lys Pro 
        195                 200                 205             


Pro Val Gly Thr Trp Leu Gly Leu Leu Asn Gly Lys Val Gly Ser Phe 
    210                 215                 220                 


Lys Phe Ile Tyr Val Asp Val Leu Pro Glu Glu Ala Val Gly His Ala 
225                 230                 235                 240 


Arg Pro Ser Arg Arg Gln Ser Lys Gly Lys Arg Pro Lys Pro Lys Thr 
                245                 250                 255     


Leu His Glu Leu Leu Glu Arg Ile Gly Leu Glu Glu His Thr Ser Thr 
            260                 265                 270         


Leu Leu Leu Asn Gly Tyr Gln Thr Leu Glu Asp Phe Lys Glu Leu Arg 
        275                 280                 285             


Glu Thr His Leu Asn Glu Leu Asn Ile Met Asp Pro Gln His Arg Ala 
    290                 295                 300                 


Lys Leu Leu Thr Ala Ala Glu Leu Leu Leu Asp Tyr Asp Thr Gly Ser 
305                 310                 315                 320 


Glu Glu Ala Glu Glu Gly Ala Glu Ser Ser Gln Glu Pro Val Ala His 
                325                 330                 335     


Thr Val Ser Glu Pro Lys Val Asp Ile Pro Arg Asp Ser Gly Cys Phe 
            340                 345                 350         


Glu Gly Ser Glu Ser Gly Arg Asp Asp Ala Glu Leu Ala Gly Thr Glu 
        355                 360                 365             


Glu Gln Leu Gln Gly Leu Ser Leu Ala Gly Ala Pro 
    370                 375                 380 


<210> 5912
<211> 563
<212> PRT
<213> Homo sapiens

<400> 5912
Met Asn Pro Leu Phe Gly Pro Asn Leu Phe Leu Leu Gln Gln Glu Gln 
1               5                   10                  15      


Gln Gly Leu Ala Gly Pro Leu Gly Asp Ser Leu Gly Gly Asp His Phe 
            20                  25                  30          


Ala Gly Gly Gly Asp Leu Pro Pro Ala Pro Leu Ser Pro Ala Gly Pro 
        35                  40                  45              


Ala Ala Tyr Ser Pro Pro Gly Pro Gly Pro Ala Pro Pro Ala Ala Met 
    50                  55                  60                  


Ala Leu Arg Asn Asp Leu Gly Ser Asn Ile Asn Val Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Leu Arg Phe Arg Cys Phe Leu Ala Lys Val His Glu Leu Glu Arg 
                85                  90                  95      


Arg Asn Arg Leu Leu Glu Lys Gln Leu Gln Gln Ala Leu Glu Glu Gly 
            100                 105                 110         


Lys Gln Gly Arg Arg Gly Leu Gly Arg Arg Asp Gln Ala Val Gln Thr 
        115                 120                 125             


Gly Phe Val Ser Pro Ile Arg Pro Leu Gly Leu Gln Leu Gly Ala Arg 
    130                 135                 140                 


Pro Ala Ala Val Cys Ser Pro Ser Ala Arg Val Leu Gly Ser Pro Ala 
145                 150                 155                 160 


Arg Ser Pro Ala Gly Pro Leu Ala Pro Ser Ala Ala Ser Leu Ser Ser 
                165                 170                 175     


Ser Ser Thr Ser Thr Ser Thr Thr Tyr Ser Ser Ser Ala Arg Phe Met 
            180                 185                 190         


Pro Gly Thr Ile Trp Ser Phe Ser His Ala Arg Arg Leu Gly Pro Gly 
        195                 200                 205             


Leu Glu Pro Thr Leu Val Gln Gly Pro Gly Leu Ser Trp Val His Pro 
    210                 215                 220                 


Asp Gly Val Gly Val Gln Ile Asp Thr Ile Thr Pro Glu Ile Arg Ala 
225                 230                 235                 240 


Leu Tyr Asn Val Leu Ala Lys Val Lys Arg Glu Arg Asp Glu Tyr Lys 
                245                 250                 255     


Arg Arg Trp Glu Glu Glu Tyr Thr Val Arg Ile Gln Leu Gln Asp Arg 
            260                 265                 270         


Val Asn Glu Leu Gln Glu Glu Ala Gln Glu Ala Asp Ala Cys Gln Glu 
        275                 280                 285             


Glu Leu Ala Leu Lys Val Glu Gln Leu Lys Ala Glu Leu Val Val Phe 
    290                 295                 300                 


Lys Gly Leu Met Ser Asn Asn Leu Ser Glu Leu Asp Thr Lys Ile Gln 
305                 310                 315                 320 


Glu Lys Ala Met Lys Val Asp Met Asp Ile Cys Arg Arg Ile Asp Ile 
                325                 330                 335     


Thr Ala Lys Leu Cys Asp Val Ala Gln Gln Arg Asn Cys Glu Asp Met 
            340                 345                 350         


Ile Gln Met Phe Gln Lys Lys Leu Val Pro Ser Met Gly Gly Arg Lys 
        355                 360                 365             


Arg Glu Arg Lys Ala Ala Val Glu Glu Asp Thr Ser Leu Ser Glu Ser 
    370                 375                 380                 


Glu Gly Pro Arg Gln Pro Asp Gly Asp Glu Glu Glu Ser Thr Ala Leu 
385                 390                 395                 400 


Ser Ile Asn Glu Glu Met Gln Arg Met Leu Asn Gln Leu Arg Glu Tyr 
                405                 410                 415     


Asp Phe Glu Asp Asp Cys Asp Ser Leu Thr Trp Glu Glu Thr Glu Glu 
            420                 425                 430         


Thr Leu Leu Leu Trp Glu Asp Phe Ser Gly Tyr Ala Met Ala Ala Ala 
        435                 440                 445             


Glu Ala Gln Gly Glu Gln Gln Glu Asp Ser Leu Glu Lys Val Ile Lys 
    450                 455                 460                 


Asp Thr Glu Ser Leu Phe Lys Thr Arg Glu Lys Glu Tyr Gln Glu Thr 
465                 470                 475                 480 


Ile Asp Gln Ile Glu Leu Glu Leu Ala Thr Ala Lys Asn Asp Met Asn 
                485                 490                 495     


Arg His Leu His Glu Tyr Met Glu Met Cys Ser Met Lys Arg Gly Leu 
            500                 505                 510         


Asp Val Gln Met Glu Thr Cys Arg Arg Leu Ile Thr Gln Ser Gly Asp 
        515                 520                 525             


Arg Lys Ser Pro Ala Phe Thr Ala Val Pro Leu Ser Asp Pro Pro Pro 
    530                 535                 540                 


Pro Pro Ser Glu Ala Glu Asp Ser Asp Arg Asp Val Ser Ser Asp Ser 
545                 550                 555                 560 


Ser Met Arg 
            


<210> 5913
<211> 630
<212> PRT
<213> Homo sapiens

<400> 5913
Met Leu Phe Leu Ala Ile Pro Gln Ser Ile Asp Glu Glu Thr Glu Val 
1               5                   10                  15      


Trp Ser Asp His Ile Ile Phe Pro Arg Ile Pro Arg Gly Pro Val Gln 
            20                  25                  30          


Gln Pro Leu Glu Asp Arg Ile Phe Thr Pro Ala Val Ser Ala Val Tyr 
        35                  40                  45              


Ser Thr Val Thr Gln Val Ala Arg Gln Pro Gly Thr Pro Thr Pro Ser 
    50                  55                  60                  


Pro Tyr Ser Ala His Glu Ile Asn Lys Gly His Pro Asn Leu Ala Ala 
65                  70                  75                  80  


Thr Pro Pro Gly His Ala Ser Ser Pro Gly Leu Ser Gln Thr Pro Tyr 
                85                  90                  95      


Pro Ser Gly Gln Asn Ala Gly Pro Thr Thr Leu Val Tyr Pro Gln Thr 
            100                 105                 110         


Pro Gln Thr Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Ala Ala 
        115                 120                 125             


Gly Pro Arg Pro Pro His His Gln Phe Phe Gln Arg Pro Gln Ile Gln 
    130                 135                 140                 


Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg Pro Gly 
145                 150                 155                 160 


Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile Met Met 
                165                 170                 175     


Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro Gln Tyr 
            180                 185                 190         


Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly Pro Pro 
        195                 200                 205             


Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr Pro Gly 
    210                 215                 220                 


Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe Tyr Pro 
225                 230                 235                 240 


Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr Gln Gln 
                245                 250                 255     


Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile Arg Asp 
            260                 265                 270         


Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser Gly Gly 
        275                 280                 285             


Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser Thr Pro 
    290                 295                 300                 


Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser Pro Val 
305                 310                 315                 320 


Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr Pro Val 
                325                 330                 335     


Thr Ala Ala Ser Asp Gln Lys Gln Glu Glu Lys Pro Lys Pro Asp Pro 
            340                 345                 350         


Val Leu Lys Ser Pro Ser Pro Val Leu Arg Leu Val Leu Ser Gly Glu 
        355                 360                 365             


Lys Lys Glu Gln Glu Gly Gln Thr Ser Glu Thr Thr Ala Ile Val Ser 
    370                 375                 380                 


Ile Ala Glu Leu Pro Leu Pro Pro Ser Pro Thr Thr Val Ser Ser Val 
385                 390                 395                 400 


Ala Arg Ser Thr Ile Ala Ala Pro Thr Ser Ser Ala Leu Ser Ser Gln 
                405                 410                 415     


Pro Ile Phe Thr Thr Ala Ile Asp Asp Arg Cys Glu Leu Ser Ser Pro 
            420                 425                 430         


Arg Glu Asp Thr Ile Pro Ile Pro Ser Leu Thr Ser Cys Thr Glu Thr 
        435                 440                 445             


Ser Asp Pro Leu Pro Thr Asn Glu Asn Asp Asp Asp Ile Cys Lys Lys 
    450                 455                 460                 


Pro Cys Ser Val Ala Pro Asn Asp Ile Pro Leu Val Ser Ser Thr Asn 
465                 470                 475                 480 


Leu Ile Asn Glu Ile Asn Gly Val Ser Glu Lys Leu Ser Ala Thr Glu 
                485                 490                 495     


Ser Ile Val Glu Ile Val Lys Gln Glu Val Leu Pro Leu Thr Leu Glu 
            500                 505                 510         


Leu Glu Ile Leu Glu Asn Pro Pro Glu Glu Met Lys Leu Glu Cys Ile 
        515                 520                 525             


Pro Ala Pro Ile Thr Pro Ser Thr Val Pro Ser Phe Pro Pro Thr Pro 
    530                 535                 540                 


Pro Thr Pro Pro Ala Ser Pro Pro His Thr Pro Val Ile Val Pro Ala 
545                 550                 555                 560 


Ala Ala Thr Thr Val Ser Ser Pro Ser Ala Ala Ile Thr Val Gln Arg 
                565                 570                 575     


Val Leu Glu Glu Asp Glu Ser Ile Arg Thr Cys Leu Ser Glu Asp Ala 
            580                 585                 590         


Lys Glu Ile Gln Asn Lys Ile Glu Val Glu Ala Asp Gly Gln Thr Glu 
        595                 600                 605             


Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser Arg Arg Ser Pro Val Pro 
    610                 615                 620                 


Glu Thr Ser Asn Glu Cys 
625                 630 


<210> 5914
<211> 137
<212> PRT
<213> Homo sapiens

<400> 5914
Met Ile Leu Pro Thr Lys Ala Met Ala Thr Gln Glu Leu Thr Val Lys 
1               5                   10                  15      


Arg Lys Leu Ser Gly Asn Thr Leu Gln Val Gln Ala Ser Ser Pro Val 
            20                  25                  30          


Ala Leu Gly Val Arg Ile Pro Thr Val Ala Leu His Met Met Glu Leu 
        35                  40                  45              


Phe Asp Thr Thr Val Glu Gln Leu Tyr Ser Ile Phe Thr Val Lys Glu 
    50                  55                  60                  


Leu Thr Asn Lys Lys Ile Ile Met Lys Trp Arg Cys Gly Asn Trp Pro 
65                  70                  75                  80  


Glu Glu His Tyr Ala Met Val Ala Leu Asn Phe Val Pro Thr Leu Gly 
                85                  90                  95      


Gln Thr Glu Leu Gln Leu Lys Glu Phe Leu Ser Ile Cys Lys Glu Glu 
            100                 105                 110         


Asn Met Lys Phe Cys Trp Gln Lys Gln His Phe Glu Glu Ile Lys Gly 
        115                 120                 125             


Ser Leu Gln Leu Thr Pro Leu Asn Gly 
    130                 135         


<210> 5915
<211> 415
<212> PRT
<213> Homo sapiens

<400> 5915
Met Met Leu Gly Pro Glu Gly Gly Glu Gly Phe Val Val Lys Leu Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Val Glu Asp Val Gln Asn Phe Leu Ser 
            20                  25                  30          


Asp Cys Thr Ile His Asp Gly Ala Ala Gly Val His Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Gln Ser Gly Glu Ala Phe Val Glu Leu Gly Ser Glu 
    50                  55                  60                  


Asp Asp Val Lys Met Ala Leu Lys Lys Asp Arg Glu Ser Met Gly His 
65                  70                  75                  80  


Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu Glu Val Arg 
            180                 185                 190         


Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly Ile Val Lys 
    210                 215                 220                 


Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser Thr Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr Gly Phe Thr 
                245                 250                 255     


Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser Gly Met Tyr 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr Gly Ala Ser 
        355                 360                 365             


Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly Val Ser Ala 
    370                 375                 380                 


Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val Ser Gly Cys 
385                 390                 395                 400 


Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly Tyr Asp 
                405                 410                 415 


<210> 5916
<211> 487
<212> PRT
<213> Homo sapiens

<400> 5916
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro 
145                 150                 155                 160 


Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu 
                165                 170                 175     


Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala 
            180                 185                 190         


Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly 
        195                 200                 205             


Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr 
    210                 215                 220                 


Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu 
225                 230                 235                 240 


Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg 
                245                 250                 255     


Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly 
            260                 265                 270         


Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val Glu 
        275                 280                 285             


Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu 
    290                 295                 300                 


Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro 
305                 310                 315                 320 


Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln 
                325                 330                 335     


Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser 
            340                 345                 350         


Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile 
        355                 360                 365             


Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp 
    370                 375                 380                 


Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met 
385                 390                 395                 400 


Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr 
                405                 410                 415     


Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala 
            420                 425                 430         


Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe 
        435                 440                 445             


Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro 
    450                 455                 460                 


Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro 
465                 470                 475                 480 


Gly Pro Ser Pro Ser Pro Gln 
                485         


<210> 5917
<211> 488
<212> PRT
<213> Homo sapiens

<400> 5917
Met Ser Ala Phe Cys Leu Gly Leu Val Gly Arg Ala Ser Ala Pro Ala 
1               5                   10                  15      


Glu Pro Asp Ser Ala Cys Cys Met Glu Leu Pro Ala Ala Ala Gly Asp 
            20                  25                  30          


Ala Val Arg Ser Pro Ala Ala Ala Ala Ala Leu Ile Phe Pro Gly Gly 
        35                  40                  45              


Ser Gly Glu Leu Glu Leu Ala Leu Glu Glu Glu Leu Ala Leu Leu Ala 
    50                  55                  60                  


Ala Gly Glu Arg Pro Ser Asp Pro Gly Glu His Pro Gln Ala Glu Leu 
65                  70                  75                  80  


Leu Ser Val Ile Arg Gln Lys Glu Lys Asp Leu Val Leu Ala Ala Arg 
                85                  90                  95      


Leu Gly Lys Ala Leu Leu Glu Arg Asn Gln Asp Met Ser Arg Gln Tyr 
            100                 105                 110         


Glu Gln Met His Lys Glu Leu Thr Asp Lys Leu Glu His Leu Glu Gln 
        115                 120                 125             


Glu Lys His Glu Leu Arg Arg Arg Phe Glu Asn Arg Glu Gly Glu Trp 
    130                 135                 140                 


Glu Gly Arg Val Ser Glu Leu Glu Ser Asp Val Lys Gln Leu Gln Asp 
145                 150                 155                 160 


Glu Leu Glu Arg Gln Gln Ile His Leu Arg Glu Ala Asp Arg Glu Lys 
                165                 170                 175     


Ser Arg Ala Val Gln Glu Leu Ser Glu Gln Asn Gln Arg Leu Leu Asp 
            180                 185                 190         


Gln Leu Ser Arg Ala Ser Glu Val Glu Arg Gln Leu Ser Met Gln Val 
        195                 200                 205             


His Ala Leu Arg Glu Asp Phe Arg Glu Lys Asn Ser Ser Thr Asn Gln 
    210                 215                 220                 


His Ile Ile Arg Leu Glu Ser Leu Gln Ala Glu Ile Lys Met Leu Ser 
225                 230                 235                 240 


Asp Arg Lys Arg Glu Leu Glu His Arg Leu Ser Ala Thr Leu Glu Glu 
                245                 250                 255     


Asn Asp Leu Leu Gln Gly Thr Val Glu Glu Leu Gln Asp Arg Val Leu 
            260                 265                 270         


Ile Leu Glu Arg Gln Gly His Asp Lys Asp Leu Gln Leu His Gln Ser 
        275                 280                 285             


Gln Leu Glu Leu Gln Glu Val Arg Leu Ser Cys Arg Gln Leu Gln Val 
    290                 295                 300                 


Lys Val Glu Glu Leu Thr Glu Glu Arg Ser Leu Gln Ser Ser Ala Ala 
305                 310                 315                 320 


Thr Ser Thr Ser Leu Leu Ser Glu Ile Glu Gln Ser Met Glu Ala Glu 
                325                 330                 335     


Glu Leu Glu Gln Glu Arg Glu Gln Leu Arg Leu Gln Leu Trp Glu Ala 
            340                 345                 350         


Tyr Cys Gln Val Arg Tyr Leu Cys Ser His Leu Arg Gly Asn Asp Ser 
        355                 360                 365             


Ala Asp Ser Ala Val Ser Thr Asp Ser Ser Met Asp Glu Ser Ser Glu 
    370                 375                 380                 


Thr Ser Ser Ala Lys Asp Val Pro Ala Gly Ser Leu Arg Thr Ala Leu 
385                 390                 395                 400 


Asn Glu Leu Lys Arg Leu Ile Gln Ser Ile Val Asp Gly Met Glu Pro 
                405                 410                 415     


Thr Gly Ser Arg Arg Leu Asp Asp Asp Ser Leu Glu Glu Gln Ile Arg 
            420                 425                 430         


Gln Thr Ser Glu Asp Ser Arg Ala Leu Arg Glu Leu Met Glu Gly Glu 
        435                 440                 445             


Arg Gly Arg Leu Pro Glu Ala Ser Arg Cys Cys Leu Pro Ala Cys Ser 
    450                 455                 460                 


Gln Pro Ile Gln Ser Pro Ser Leu Pro His Val Gly Lys Ala Gln Gln 
465                 470                 475                 480 


Gly Cys Ala Ala Arg Met Tyr Leu 
                485             


<210> 5918
<211> 475
<212> PRT
<213> Homo sapiens

<400> 5918
Met Thr Arg Gly Thr Gly Gly Thr Ala Gln Arg Gly Arg Ser Gly Pro 
1               5                   10                  15      


Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser Gly Thr Ala 
            20                  25                  30          


Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys Arg Ala Ser 
        35                  40                  45              


Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser Ser Arg Phe 
    50                  55                  60                  


Ile Lys Arg Lys Lys Phe Asp Asp Glu Leu Val Glu Ser Ser Leu Ala 
65                  70                  75                  80  


Lys Ser Ser Thr Arg Ala Lys Gly Ala Ser Gly Val Glu Pro Gly Arg 
                85                  90                  95      


Cys Ser Gly Ser Glu Pro Ser Ser Ser Glu Lys Lys Lys Val Ser Lys 
            100                 105                 110         


Ala Pro Ser Thr Pro Val Pro Pro Ser Pro Ala Pro Ala Pro Gly Leu 
        115                 120                 125             


Thr Lys Arg Val Lys Lys Ser Lys Gln Pro Leu Gln Val Thr Lys Asp 
    130                 135                 140                 


Leu Gly Arg Trp Lys Pro Ala Asp Asp Leu Leu Leu Ile Asn Ala Val 
145                 150                 155                 160 


Leu Gln Thr Asn Asp Leu Thr Ser Val His Leu Gly Val Lys Phe Ser 
                165                 170                 175     


Cys Arg Phe Thr Leu Arg Glu Val Gln Glu Arg Trp Tyr Ala Leu Leu 
            180                 185                 190         


Tyr Asp Pro Val Ile Ser Lys Leu Ala Cys Gln Ala Met Arg Gln Leu 
        195                 200                 205             


His Pro Glu Ala Ile Ala Ala Ile Gln Ser Lys Ala Leu Phe Ser Lys 
    210                 215                 220                 


Ala Glu Glu Gln Leu Leu Ser Lys Val Gly Ser Thr Ser Gln Pro Thr 
225                 230                 235                 240 


Leu Glu Thr Phe Gln Asp Leu Leu His Arg His Pro Asp Ala Phe Tyr 
                245                 250                 255     


Leu Ala Arg Thr Ala Lys Ala Leu Gln Ala His Trp Gln Leu Met Lys 
            260                 265                 270         


Gln Tyr Tyr Leu Leu Glu Asp Gln Thr Val Gln Pro Leu Pro Lys Gly 
        275                 280                 285             


Asp Gln Val Leu Asn Phe Ser Asp Ala Glu Asp Leu Ile Asp Asp Ser 
    290                 295                 300                 


Lys Leu Lys Asp Met Arg Asp Glu Val Leu Glu His Glu Leu Met Val 
305                 310                 315                 320 


Ala Asp Arg Arg Gln Lys Arg Glu Ile Arg Gln Leu Glu Gln Glu Leu 
                325                 330                 335     


His Lys Trp Gln Val Leu Val Asp Ser Ile Thr Gly Met Ser Ser Pro 
            340                 345                 350         


Asp Phe Asp Asn Gln Thr Leu Ala Val Leu Arg Gly Arg Met Val Arg 
        355                 360                 365             


Tyr Leu Met Arg Ser Arg Glu Ile Thr Leu Gly Arg Ala Thr Lys Asp 
    370                 375                 380                 


Asn Gln Ile Asp Val Asp Leu Ser Leu Glu Gly Pro Ala Trp Lys Ile 
385                 390                 395                 400 


Ser Arg Lys Gln Gly Val Ile Lys Leu Lys Asn Asn Gly Asp Phe Phe 
                405                 410                 415     


Ile Ala Asn Glu Gly Arg Arg Pro Ile Tyr Ile Asp Gly Arg Pro Val 
            420                 425                 430         


Leu Cys Gly Ser Lys Trp Arg Leu Ser Asn Asn Ser Val Val Glu Ile 
        435                 440                 445             


Ala Ser Leu Arg Phe Val Phe Leu Ile Asn Gln Asp Leu Ile Ala Leu 
    450                 455                 460                 


Ile Arg Ala Glu Ala Ala Lys Ile Thr Pro Gln 
465                 470                 475 


<210> 5919
<211> 436
<212> PRT
<213> Homo sapiens

<400> 5919
Met Ala Asp Gly Gly Ser Glu Arg Ala Asp Gly Arg Ile Val Lys Met 
1               5                   10                  15      


Glu Val Asp Tyr Ser Ala Thr Val Asp Gln Arg Leu Pro Glu Cys Ala 
            20                  25                  30          


Lys Leu Ala Lys Ala Ser Asp Met Val Ser Thr Ser Arg Ile Leu Val 
        35                  40                  45              


Ala Val Val Lys Met Cys Tyr Glu Ala Lys Glu Trp Asp Leu Leu Asn 
    50                  55                  60                  


Glu Asn Ile Met Leu Leu Ser Lys Arg Arg Ser Gln Leu Lys Gln Ala 
65                  70                  75                  80  


Val Ala Lys Met Val Gln Gln Cys Cys Thr Tyr Val Glu Glu Ile Thr 
                85                  90                  95      


Asp Leu Pro Ile Lys Leu Arg Leu Ile Asp Thr Leu Arg Met Val Thr 
            100                 105                 110         


Glu Gly Lys Ile Tyr Val Glu Ile Glu Arg Ala Arg Leu Thr Lys Thr 
        115                 120                 125             


Leu Ala Thr Ile Lys Glu Gln Asn Gly Asp Val Lys Glu Ala Ala Ser 
    130                 135                 140                 


Ile Leu Gln Glu Leu Gln Val Glu Thr Tyr Gly Ser Met Glu Lys Lys 
145                 150                 155                 160 


Glu Arg Val Glu Phe Ile Leu Glu Gln Met Arg Leu Cys Leu Ala Val 
                165                 170                 175     


Lys Asp Tyr Ile Arg Thr Gln Ile Ile Ser Lys Lys Ile Asn Thr Lys 
            180                 185                 190         


Phe Phe Gln Glu Glu Asn Thr Glu Lys Leu Lys Leu Lys Tyr Tyr Asn 
        195                 200                 205             


Leu Met Ile Gln Leu Asp Gln His Glu Gly Ser Tyr Leu Ser Ile Cys 
    210                 215                 220                 


Lys His Tyr Arg Ala Ile Tyr Asp Thr Pro Cys Ile Gln Ala Glu Ser 
225                 230                 235                 240 


Glu Lys Trp Gln Gln Ala Leu Lys Ser Val Val Leu Tyr Val Ile Leu 
                245                 250                 255     


Ala Pro Phe Asp Asn Glu Gln Ser Asp Leu Val His Arg Ile Ser Gly 
            260                 265                 270         


Asp Lys Lys Leu Glu Glu Ile Pro Lys Tyr Lys Asp Leu Leu Lys Leu 
        275                 280                 285             


Phe Thr Thr Met Glu Leu Met Arg Trp Ser Thr Leu Val Glu Asp Tyr 
    290                 295                 300                 


Gly Met Glu Leu Arg Lys Gly Ser Leu Glu Ser Pro Ala Thr Asp Val 
305                 310                 315                 320 


Phe Gly Ser Thr Glu Glu Gly Glu Lys Arg Trp Lys Asp Leu Lys Asn 
                325                 330                 335     


Arg Val Val Glu His Asn Ile Arg Ile Met Ala Lys Tyr Tyr Thr Arg 
            340                 345                 350         


Ile Thr Met Lys Arg Met Ala Gln Leu Leu Asp Leu Ser Val Asp Glu 
        355                 360                 365             


Ser Glu Ala Phe Leu Ser Asn Leu Val Val Asn Lys Thr Ile Phe Ala 
    370                 375                 380                 


Lys Val Asp Arg Leu Ala Gly Ile Ile Asn Phe Gln Arg Pro Lys Asp 
385                 390                 395                 400 


Pro Asn Asn Leu Leu Asn Asp Trp Ser Gln Lys Leu Asn Ser Leu Met 
                405                 410                 415     


Ser Leu Val Asn Lys Thr Thr His Leu Ile Ala Lys Glu Glu Met Ile 
            420                 425                 430         


His Asn Leu Gln 
        435     


<210> 5920
<211> 657
<212> PRT
<213> Homo sapiens

<400> 5920
Met Asp Asp Pro Asp Cys Asp Ser Thr Trp Glu Glu Asp Glu Glu Asp 
1               5                   10                  15      


Ala Glu Asp Ala Glu Asp Glu Asp Cys Glu Asp Gly Glu Ala Ala Gly 
            20                  25                  30          


Ala Arg Asp Ala Asp Ala Gly Asp Glu Asp Glu Glu Ser Glu Glu Pro 
        35                  40                  45              


Arg Ala Ala Arg Pro Ser Ser Phe Gln Ser Arg Met Thr Gly Ser Arg 
    50                  55                  60                  


Asn Trp Arg Ala Thr Arg Asp Met Cys Arg Tyr Arg His Asn Tyr Pro 
65                  70                  75                  80  


Asp Leu Val Glu Arg Asp Cys Asn Gly Asp Thr Pro Asn Leu Ser Phe 
                85                  90                  95      


Tyr Arg Asn Glu Ile Arg Phe Leu Pro Asn Gly Cys Phe Ile Glu Asp 
            100                 105                 110         


Ile Leu Gln Asn Trp Thr Asp Asn Tyr Asp Leu Leu Glu Asp Asn His 
        115                 120                 125             


Ser Tyr Ile Gln Trp Leu Phe Pro Leu Arg Glu Pro Gly Val Asn Trp 
    130                 135                 140                 


His Ala Lys Pro Leu Thr Leu Arg Glu Val Glu Val Phe Lys Ser Ser 
145                 150                 155                 160 


Gln Glu Ile Gln Glu Arg Leu Val Arg Ala Tyr Glu Leu Met Leu Gly 
                165                 170                 175     


Phe Tyr Gly Ile Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg 
            180                 185                 190         


Ala Gln Asn Tyr Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His 
        195                 200                 205             


Asn Asn Leu Arg Ile Thr Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly 
    210                 215                 220                 


Leu Glu His Phe Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr 
225                 230                 235                 240 


Leu Val Arg Arg Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr 
                245                 250                 255     


Phe Met Phe Ala Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His 
            260                 265                 270         


Phe Ala Trp Glu His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro 
        275                 280                 285             


Gln Asp Lys Leu Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu 
    290                 295                 300                 


Glu Gly Ser Arg Lys Val Glu Glu Glu Gly Ser Pro Gly Asp Pro Asp 
305                 310                 315                 320 


His Glu Ala Ser Thr Gln Gly Arg Thr Cys Gly Pro Glu His Ser Lys 
                325                 330                 335     


Gly Gly Gly Arg Val Asp Glu Gly Pro Gln Pro Arg Ser Val Glu Pro 
            340                 345                 350         


Gln Asp Ala Gly Pro Leu Glu Arg Ser Gln Gly Asp Glu Ala Gly Gly 
        355                 360                 365             


His Gly Glu Asp Arg Pro Glu Pro Leu Ser Pro Lys Glu Ser Lys Lys 
    370                 375                 380                 


Arg Lys Leu Glu Leu Ser Arg Arg Glu Gln Pro Pro Thr Glu Pro Gly 
385                 390                 395                 400 


Pro Gln Ser Ala Ser Glu Val Glu Lys Ile Ala Leu Asn Leu Glu Gly 
                405                 410                 415     


Cys Ala Leu Ser Gln Gly Ser Leu Arg Thr Gly Thr Gln Glu Val Gly 
            420                 425                 430         


Gly Gln Asp Pro Gly Glu Ala Val Gln Pro Cys Arg Gln Pro Leu Gly 
        435                 440                 445             


Ala Arg Val Ala Asp Lys Val Arg Lys Arg Arg Lys Val Asp Glu Gly 
    450                 455                 460                 


Ala Gly Asp Ser Ala Ala Val Ala Ser Gly Gly Ala Gln Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Gly Ser Pro Ala Pro Ser Gly His Pro Lys Ala Gly His Ser 
                485                 490                 495     


Glu Asn Gly Val Glu Glu Asp Thr Glu Gly Arg Thr Gly Pro Lys Glu 
            500                 505                 510         


Gly Thr Pro Gly Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly 
        515                 520                 525             


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
    530                 535                 540                 


Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu 
545                 550                 555                 560 


Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Glu 
                565                 570                 575     


Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly Pro Ala Gly Asp 
            580                 585                 590         


Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly 
        595                 600                 605             


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
    610                 615                 620                 


Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Lys Ala Gly Glu Ala 
625                 630                 635                 640 


Ala Glu Leu Gln Asp Ala Glu Val Glu Ser Ser Ala Lys Ser Gly Lys 
                645                 650                 655     


Pro 
    


<210> 5921
<211> 204
<212> PRT
<213> Homo sapiens

<400> 5921
Met Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro 
1               5                   10                  15      


Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu 
        35                  40                  45              


Glu Glu Ala Ser Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu 
    50                  55                  60                  


Lys Ser Lys Arg Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys 
65                  70                  75                  80  


Ala Val Gln Arg Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu 
                85                  90                  95      


Asn Glu Asn Gln Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg 
            100                 105                 110         


Glu Leu Gly Tyr Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val 
    130                 135                 140                 


Ile Arg Gln Ser Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Trp Glu Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly 
                165                 170                 175     


Gly Ser Glu Asp Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu 
            180                 185                 190         


Glu Pro Gln Arg Pro Ser Pro Ser Glu Pro Gly Thr 
        195                 200                 


<210> 5922
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 5922
Met Gly Trp Lys Pro Ser Glu Ala Arg Gly Gln Ser Gln Ser Phe Gln 
1               5                   10                  15      


Ala Ser Gly Leu Gln Pro Arg Ser Leu Lys Ala Ala Arg Arg Ala Thr 
            20                  25                  30          


Gly Arg Pro Asp Arg Ser Arg Ala Ala Arg Pro Thr Met Asp Pro Ser 
        35                  40                  45              


Ala His Arg Ser Arg Ala Ala Pro Pro Asn Met Asp Pro Asp Pro Gln 
    50                  55                  60                  


Ala Gly Val Gln Val Gly Met Arg Val Val Arg Gly Val Asp Trp Lys 
65                  70                  75                  80  


Trp Gly Gln Gln Asp Gly Gly Glu Gly Gly Val Gly Thr Val Val Glu 
                85                  90                  95      


Leu Gly Arg His Gly Ser Pro Ser Thr Pro Asp Arg Thr Val Val Val 
            100                 105                 110         


Gln Trp Asp Gln Gly Thr Arg Thr Asn Tyr Arg Ala Gly Tyr Gln Gly 
        115                 120                 125             


Ala His Asp Leu Leu Leu Tyr Asp Asn Ala Gln Ile Gly Val Arg His 
    130                 135                 140                 


Pro Asn Ile Ile Cys Asp Cys Cys Lys Lys His Gly Leu Arg Gly Met 
145                 150                 155                 160 


Arg Trp Lys Cys Arg Val Cys Leu Asp Tyr Asp Leu Cys Thr Gln Cys 
                165                 170                 175     


Tyr Met His Asn Lys His Glu Leu Ala His Ala Phe Asp Arg Tyr Glu 
            180                 185                 190         


Thr Ala His Ser Arg Pro Val Thr Leu Ser Pro Arg Gln Gly Leu Pro 
        195                 200                 205             


Arg Ile Pro Leu Arg Gly Ile Phe Gln Gly Ala Lys Val Val Arg Gly 
    210                 215                 220                 


Pro Asp Trp Glu Trp Gly Ser Gln Asp Gly Gly Glu Gly Lys Pro Gly 
225                 230                 235                 240 


Arg Val Val Asp Ile Arg Gly Trp Asp Val Glu Thr Gly Arg Ser Val 
                245                 250                 255     


Ala Ser Val Thr Trp Ala Asp Gly Thr Thr Asn Val Tyr Arg Val Gly 
            260                 265                 270         


His Lys Gly Lys Val Asp Leu Lys Cys Val Gly Glu Ala Ala Gly Gly 
        275                 280                 285             


Phe Tyr Tyr Lys Asp His Leu Pro Arg Leu Gly Lys Pro Ala Glu Leu 
    290                 295                 300                 


Gln Arg Arg Val Ser Ala Asp Ser Gln Pro Phe Gln His Gly Asp Lys 
305                 310                 315                 320 


Val Lys Cys Leu Leu Asp Thr Asp Val Leu Arg Glu Met Gln Glu Gly 
                325                 330                 335     


His Gly Gly Trp Asn Pro Arg Met Ala Glu Phe Ile Gly Gln Thr Gly 
            340                 345                 350         


Thr Val His Arg Ile Thr Asp Arg Gly Asp Val Arg Val Gln Phe Asn 
        355                 360                 365             


His Glu Thr Arg Trp Thr Phe His Pro Gly Ala Leu Thr Lys His His 
    370                 375                 380                 


Ser Phe Trp Val Gly Asp Val Val Arg Val Ile Gly Asp Leu Asp Thr 
385                 390                 395                 400 


Val Lys Arg Leu Gln Ala Gly His Gly Glu Trp Thr Asp Asp Met Ala 
                405                 410                 415     


Pro Ala Leu Gly Arg Val Gly Lys Val Val Lys Val Phe Gly Asp Gly 
            420                 425                 430         


Asn Leu Arg Val Ala Val Ala Gly Gln Arg Trp Thr Phe Ser Pro Ser 
        435                 440                 445             


Cys Leu Val Ala Tyr Arg Pro Glu Glu Asp Ala Asn Leu Asp Val Ala 
    450                 455                 460                 


Glu Arg Ala Arg Glu Asn Lys Ser Ser Leu Ser Val Ala Leu Asp Lys 
465                 470                 475                 480 


Leu Arg Ala Gln Lys Ser Asp Pro Glu His Pro Gly Arg Leu Val Val 
                485                 490                 495     


Glu Val Ala Leu Gly Asn Ala Ala Arg Ala Leu Asp Leu Leu Arg Arg 
            500                 505                 510         


Arg Pro Glu Gln Val Asp Thr Lys Asn Gln Gly Arg Thr Ala Leu Gln 
        515                 520                 525             


Val Ala Ala Tyr Leu Gly Gln Val Glu Leu Ile Arg Leu Leu Leu Gln 
    530                 535                 540                 


Ala Arg Ala Gly Val Asp Leu Pro Asp Asp Glu Gly Asn Thr Ala Leu 
545                 550                 555                 560 


His Tyr Ala Ala Leu Gly Asn Gln Pro Glu Ala Thr Arg Val Leu Leu 
                565                 570                 575     


Ser Ala Gly Cys Arg Ala Asp Ala Ile Asn Ser Thr Gln Ser Thr Ala 
            580                 585                 590         


Leu His Val Ala Val Gln Arg Gly Phe Leu Glu Val Val Arg Ala Leu 
        595                 600                 605             


Cys Glu Arg Gly Cys Asp Val Asn Leu Pro Asp Ala His Ser Asp Thr 
    610                 615                 620                 


Pro Leu His Ser Ala Ile Ser Ala Gly Thr Gly Ala Ser Gly Ile Val 
625                 630                 635                 640 


Glu Val Leu Thr Glu Val Pro Asn Ile Asp Val Thr Ala Thr Asn Ser 
                645                 650                 655     


Gln Gly Phe Thr Leu Leu His His Ala Ser Leu Lys Gly His Ala Leu 
            660                 665                 670         


Ala Val Arg Lys Ile Leu Ala Arg Ala Arg Gln Leu Val Asp Ala Lys 
        675                 680                 685             


Lys Glu Asp Gly Phe Thr Ala Leu His Leu Ala Ala Leu Asn Asn His 
    690                 695                 700                 


Arg Glu Val Ala Gln Ile Leu Ile Arg Glu Gly Arg Cys Asp Val Asn 
705                 710                 715                 720 


Val Arg Asn Arg Lys Leu Gln Ser Pro Leu His Leu Ala Val Gln Gln 
                725                 730                 735     


Ala His Val Gly Leu Val Pro Leu Leu Val Asp Ala Gly Cys Ser Val 
            740                 745                 750         


Asn Ala Glu Asp Glu Glu Gly Asp Thr Ala Leu His Val Ala Leu Gln 
        755                 760                 765             


Arg His Gln Leu Leu Pro Leu Val Ala Asp Gly Ala Gly Gly Asp Pro 
    770                 775                 780                 


Gly Pro Leu Gln Leu Leu Ser Arg Leu Gln Ala Ser Gly Leu Pro Gly 
785                 790                 795                 800 


Ser Ala Glu Leu Thr Val Gly Ala Ala Val Ala Cys Phe Leu Ala Leu 
                805                 810                 815     


Glu Gly Ala Asp Val Ser Tyr Thr Asn His Arg Gly Arg Ser Pro Leu 
            820                 825                 830         


Asp Leu Ala Ala Glu Gly Arg Val Leu Lys Ala Leu Gln Gly Cys Ala 
        835                 840                 845             


Gln Arg Phe Arg Glu Arg Gln Ala Gly Gly Gly Ala Ala Pro Gly Pro 
    850                 855                 860                 


Arg Gln Thr Leu Gly Thr Pro Asn Thr Val Thr Asn Leu His Val Gly 
865                 870                 875                 880 


Ala Ala Pro Gly Pro Glu Ala Ala Glu Cys Leu Val Cys Ser Glu Leu 
                885                 890                 895     


Ala Leu Leu Val Leu Phe Ser Pro Cys Gln His Arg Thr Val Cys Glu 
            900                 905                 910         


Glu Cys Ala Arg Arg Met Lys Lys Cys Ile Arg Cys Gln Val Val Val 
        915                 920                 925             


Ser Lys Lys Leu Arg Pro Asp Gly Ser Glu Val Ala Ser Ala Ala Pro 
    930                 935                 940                 


Ala Pro Gly Pro Pro Arg Gln Leu Val Glu Glu Leu Gln Ser Arg Tyr 
945                 950                 955                 960 


Arg Gln Met Glu Glu Arg Ile Thr Cys Pro Ile Cys Ile Asp Ser His 
                965                 970                 975     


Ile Arg Leu Val Phe Gln Cys Gly His Gly Ala Cys Ala Pro Cys Gly 
            980                 985                 990         


Ser Ala Leu Ser Ala Cys Pro Ile  Cys Arg Gln Pro Ile  Arg Asp Arg 
        995                 1000                 1005             


Ile Gln  Ile Phe Val 
    1010             


<210> 5923
<211> 684
<212> PRT
<213> Homo sapiens

<400> 5923
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Thr Ile 
            260                 265                 270         


Arg Lys Ala Gln Asn Leu Leu Lys Gln Tyr Ser Gln His Gly Leu Asp 
        275                 280                 285             


Gly Lys Lys Gly Gly Ser Asn Leu Ile Pro Leu Glu Gly Arg Asp Asp 
    290                 295                 300                 


Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Val Ser Ala Phe 
305                 310                 315                 320 


Val Lys Leu Ala Gln Ser Glu Tyr Gln Leu Leu Ala Asp Ile Ile Pro 
                325                 330                 335     


Glu His His Gln Lys Lys Thr Phe Asp Ser Leu Ile Gln Asp Ala Leu 
            340                 345                 350         


Asp Gly Leu Met Leu Glu Gly Glu Asn Ile Val Ser Ala Ala Arg Lys 
        355                 360                 365             


Ala Ile Val Arg His Asp Phe Ser Thr Val Leu Thr Val Phe Pro Ile 
    370                 375                 380                 


Leu Arg His Leu Lys Gln Thr Lys Pro Glu Phe Asp Gln Val Leu Gln 
385                 390                 395                 400 


Gly Thr Ala Ala Ser Thr Lys Asn Lys Leu Pro Gly Leu Ile Thr Ser 
                405                 410                 415     


Met Glu Thr Ile Gly Ala Lys Ala Leu Glu Asp Phe Ala Asp Asn Ile 
            420                 425                 430         


Lys Asn Asp Pro Asp Lys Glu Tyr Asn Met Pro Lys Asp Gly Thr Val 
        435                 440                 445             


His Glu Leu Thr Ser Asn Ala Ile Leu Phe Leu Gln Gln Leu Leu Asp 
    450                 455                 460                 


Phe Gln Glu Thr Ala Gly Ala Met Leu Ala Ser Gln Glu Thr Ser Ser 
465                 470                 475                 480 


Ser Ala Thr Ser Tyr Ser Ser Glu Phe Ser Lys Arg Leu Leu Ser Thr 
                485                 490                 495     


Tyr Ile Cys Lys Val Leu Gly Asn Leu Gln Leu Asn Leu Leu Ser Lys 
            500                 505                 510         


Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser Ala Ile Phe Leu His Asn 
        515                 520                 525             


Asn Tyr Asn Tyr Ile Leu Lys Ser Leu Glu Lys Ser Glu Leu Ile Gln 
    530                 535                 540                 


Leu Val Ala Val Thr Gln Lys Thr Ala Glu Arg Ser Tyr Arg Glu His 
545                 550                 555                 560 


Ile Glu Gln Gln Ile Gln Thr Tyr Gln Arg Ser Trp Leu Lys Val Thr 
                565                 570                 575     


Asp Tyr Ile Ala Glu Lys Asn Leu Pro Val Phe Gln Pro Gly Val Lys 
            580                 585                 590         


Leu Arg Asp Lys Glu Arg Gln Ile Ile Lys Glu Arg Phe Lys Gly Phe 
        595                 600                 605             


Asn Asp Gly Leu Glu Glu Leu Cys Lys Ile Gln Lys Ala Trp Ala Ile 
    610                 615                 620                 


Pro Asp Thr Glu Gln Arg Asp Arg Ile Arg Gln Ala Gln Lys Thr Ile 
625                 630                 635                 640 


Val Lys Glu Thr Tyr Gly Ala Phe Leu Gln Lys Phe Gly Ser Val Pro 
                645                 650                 655     


Phe Thr Lys Asn Pro Glu Lys Tyr Ile Lys Tyr Gly Val Glu Gln Val 
            660                 665                 670         


Gly Asp Met Ile Asp Arg Leu Phe Asp Thr Ser Ala 
        675                 680                 


<210> 5924
<211> 1191
<212> PRT
<213> Homo sapiens

<400> 5924
Met Pro Val Gln Ala Ala Gln Trp Thr Glu Phe Leu Ser Cys Pro Ile 
1               5                   10                  15      


Cys Tyr Asn Glu Phe Asp Glu Asn Val His Lys Pro Ile Ser Leu Gly 
            20                  25                  30          


Cys Ser His Thr Val Cys Lys Thr Cys Leu Asn Lys Leu His Arg Lys 
        35                  40                  45              


Ala Cys Pro Phe Asp Gln Thr Ala Ile Asn Thr Asp Ile Asp Val Leu 
    50                  55                  60                  


Pro Val Asn Phe Ala Leu Leu Gln Leu Val Gly Ala Gln Val Pro Asp 
65                  70                  75                  80  


His Gln Ser Ile Lys Leu Ser Asn Leu Gly Glu Asn Lys His Tyr Glu 
                85                  90                  95      


Val Ala Lys Lys Cys Val Glu Asp Leu Ala Leu Tyr Leu Lys Pro Leu 
            100                 105                 110         


Ser Gly Gly Lys Gly Val Ala Ser Leu Asn Gln Ser Ala Leu Ser Arg 
        115                 120                 125             


Pro Met Gln Arg Lys Leu Val Thr Leu Val Asn Cys Gln Leu Val Glu 
    130                 135                 140                 


Glu Glu Gly Arg Val Arg Ala Met Arg Ala Ala Arg Ser Leu Gly Glu 
145                 150                 155                 160 


Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro Gln Gln Leu 
                165                 170                 175     


Ser Ala Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys Gln Phe Leu 
            180                 185                 190         


Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu Leu Ala Leu 
        195                 200                 205             


Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu Phe Val Val 
    210                 215                 220                 


Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr Ser Ile Gly 
225                 230                 235                 240 


His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys Val Thr Lys 
                245                 250                 255     


Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu Phe Arg Ser 
            260                 265                 270         


Tyr Glu Ala Leu Arg Arg Glu His Asp Ala Gln Ile Val His Ile Ala 
        275                 280                 285             


Met Glu Ala Gly Leu Arg Ile Ser Pro Glu Gln Trp Ser Ser Leu Leu 
    290                 295                 300                 


Tyr Gly Asp Leu Ala His Lys Ser His Met Gln Ser Ile Ile Asp Lys 
305                 310                 315                 320 


Leu Gln Ser Pro Glu Ser Phe Ala Lys Ser Val Gln Glu Leu Thr Ile 
                325                 330                 335     


Val Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg Leu Arg Pro 
            340                 345                 350         


His Leu Glu Leu Leu Ala Asn Ile Asp Pro Asn Pro Asp Ala Val Ser 
        355                 360                 365             


Pro Thr Trp Glu Gln Leu Glu Asn Ala Met Val Ala Val Lys Thr Val 
    370                 375                 380                 


Val His Gly Leu Val Asp Phe Ile Gln Asn Tyr Ser Arg Lys Gly His 
385                 390                 395                 400 


Glu Thr Pro Gln Pro Gln Pro Asn Ser Lys Tyr Lys Thr Ser Met Cys 
                405                 410                 415     


Arg Asp Leu Arg Gln Gln Gly Gly Cys Pro Arg Gly Thr Asn Cys Thr 
            420                 425                 430         


Phe Ala His Ser Gln Glu Glu Leu Glu Lys Tyr Arg Leu Arg Asn Lys 
        435                 440                 445             


Lys Ile Asn Ala Thr Val Arg Thr Phe Pro Leu Leu Asn Lys Val Gly 
    450                 455                 460                 


Val Asn Asn Thr Val Thr Thr Thr Ala Gly Asn Val Ile Ser Val Ile 
465                 470                 475                 480 


Gly Ser Thr Glu Thr Thr Gly Lys Ile Val Pro Ser Thr Asn Gly Ile 
                485                 490                 495     


Ser Asn Ala Glu Asn Ser Val Ser Gln Leu Ile Ser Arg Ser Thr Asp 
            500                 505                 510         


Ser Thr Leu Arg Ala Leu Glu Thr Val Lys Lys Val Gly Lys Val Gly 
        515                 520                 525             


Ala Asn Gly Gln Asn Ala Ala Gly Pro Ser Ala Asp Ser Val Thr Glu 
    530                 535                 540                 


Asn Lys Ile Gly Ser Pro Pro Lys Thr Pro Val Ser Asn Val Ala Ala 
545                 550                 555                 560 


Thr Ser Ala Gly Pro Ser Asn Val Gly Thr Glu Leu Asn Ser Val Pro 
                565                 570                 575     


Gln Lys Ser Ser Pro Phe Leu Thr Arg Val Pro Val Tyr Pro Pro His 
            580                 585                 590         


Ser Glu Asn Ile Gln Tyr Phe Gln Asp Pro Arg Thr Gln Ile Pro Phe 
        595                 600                 605             


Glu Val Pro Gln Tyr Pro Gln Thr Gly Tyr Tyr Pro Pro Pro Pro Thr 
    610                 615                 620                 


Val Pro Ala Gly Val Ala Pro Cys Val Pro Arg Phe Val Arg Ser Asn 
625                 630                 635                 640 


Asn Val Pro Glu Ser Ser Leu Pro Pro Ala Ser Met Pro Tyr Ala Asp 
                645                 650                 655     


His Tyr Ser Thr Phe Ser Pro Arg Asp Arg Met Asn Ser Ser Pro Tyr 
            660                 665                 670         


Gln Pro Pro Pro Pro Gln Pro Tyr Gly Pro Val Pro Pro Val Pro Ser 
        675                 680                 685             


Gly Met Tyr Ala Pro Val Tyr Asp Ser Arg Arg Ile Trp Arg Pro Pro 
    690                 695                 700                 


Met Tyr Gln Arg Asp Asp Ile Ile Arg Ser Asn Ser Leu Pro Pro Met 
705                 710                 715                 720 


Asp Val Met His Ser Ser Val Tyr Gln Thr Ser Leu Arg Glu Arg Tyr 
                725                 730                 735     


Asn Ser Leu Asp Gly Tyr Tyr Ser Val Ala Cys Gln Pro Pro Ser Glu 
            740                 745                 750         


Pro Arg Thr Thr Val Pro Leu Pro Arg Glu Pro Cys Gly His Leu Lys 
        755                 760                 765             


Thr Ser Cys Glu Glu Gln Ile Arg Arg Lys Pro Asp Gln Trp Ala Gln 
    770                 775                 780                 


Tyr His Thr Gln Lys Ala Pro Leu Val Ser Ser Thr Leu Pro Val Ala 
785                 790                 795                 800 


Thr Gln Ser Pro Thr Pro Pro Ser Pro Leu Phe Ser Val Asp Phe Arg 
                805                 810                 815     


Ala Asp Phe Ser Glu Ser Val Ser Gly Thr Lys Phe Glu Glu Asp His 
            820                 825                 830         


Leu Ser His Tyr Ser Pro Trp Ser Cys Gly Thr Ile Gly Ser Cys Ile 
        835                 840                 845             


Asn Ala Ile Asp Ser Glu Pro Lys Asp Val Ile Ala Asn Ser Asn Ala 
    850                 855                 860                 


Val Leu Met Asp Leu Asp Ser Gly Asp Val Lys Arg Arg Val His Leu 
865                 870                 875                 880 


Phe Glu Thr Gln Arg Arg Thr Lys Glu Glu Asp Pro Ile Ile Pro Phe 
                885                 890                 895     


Ser Asp Gly Pro Ile Ile Ser Lys Trp Gly Ala Ile Ser Arg Ser Ser 
            900                 905                 910         


Arg Thr Gly Tyr His Thr Thr Asp Pro Val Gln Ala Thr Ala Ser Gln 
        915                 920                 925             


Gly Ser Ala Thr Lys Pro Ile Ser Val Ser Asp Tyr Val Pro Tyr Val 
    930                 935                 940                 


Asn Ala Val Asp Ser Arg Trp Ser Ser Tyr Gly Asn Glu Ala Thr Ser 
945                 950                 955                 960 


Ser Ala His Tyr Val Glu Arg Asp Arg Phe Ile Val Thr Asp Leu Ser 
                965                 970                 975     


Gly His Arg Lys His Ser Ser Thr Gly Asp Leu Leu Ser Leu Glu Leu 
            980                 985                 990         


Gln Gln Ala Lys Ser Asn Ser Leu  Leu Leu Gln Arg Glu  Ala Asn Ala 
        995                 1000                 1005             


Leu Ala  Met Gln Gln Lys Trp  Asn Ser Leu Asp Glu  Gly Arg His 
    1010                 1015                 1020             


Leu Thr  Leu Asn Leu Leu Ser  Lys Glu Ile Glu Leu  Arg Asn Gly 
    1025                 1030                 1035             


Glu Leu  Gln Ser Asp Tyr Thr  Glu Asp Ala Thr Asp  Thr Lys Pro 
    1040                 1045                 1050             


Asp Arg  Asp Ile Glu Leu Glu  Leu Ser Ala Leu Asp  Thr Asp Glu 
    1055                 1060                 1065             


Pro Asp  Gly Gln Ser Glu Pro  Ile Glu Glu Ile Leu  Asp Ile Gln 
    1070                 1075                 1080             


Leu Gly  Ile Ser Ser Gln Asn  Asp Gln Leu Leu Asn  Gly Met Ala 
    1085                 1090                 1095             


Val Glu  Asn Gly His Pro Val  Gln Gln His Gln Lys  Glu Pro Pro 
    1100                 1105                 1110             


Lys Gln  Lys Lys Gln Ser Leu  Gly Glu Asp His Val  Ile Leu Glu 
    1115                 1120                 1125             


Glu Gln  Lys Thr Ile Leu Pro  Val Thr Ser Cys Phe  Ser Gln Pro 
    1130                 1135                 1140             


Leu Pro  Val Ser Ile Ser Asn  Ala Ser Cys Leu Pro  Ile Thr Thr 
    1145                 1150                 1155             


Ser Val  Ser Ala Gly Asn Leu  Ile Leu Lys Thr His  Val Met Ser 
    1160                 1165                 1170             


Glu Asp  Lys Asn Asp Phe Leu  Lys Pro Val Ala Asn  Gly Lys Met 
    1175                 1180                 1185             


Val Asn  Ser 
    1190     


<210> 5925
<211> 699
<212> PRT
<213> Homo sapiens

<400> 5925
Met Cys Gly Ile Phe Ala Tyr Leu Asn Tyr His Val Pro Arg Thr Arg 
1               5                   10                  15      


Arg Glu Ile Leu Glu Thr Leu Ile Lys Gly Leu Gln Arg Leu Glu Tyr 
            20                  25                  30          


Arg Gly Tyr Asp Ser Ala Gly Val Gly Phe Asp Gly Gly Asn Asp Lys 
        35                  40                  45              


Asp Trp Glu Ala Asn Ala Cys Lys Ile Gln Leu Ile Lys Lys Lys Gly 
    50                  55                  60                  


Lys Val Lys Ala Leu Asp Glu Glu Val His Lys Gln Gln Asp Met Asp 
65                  70                  75                  80  


Leu Asp Ile Glu Phe Asp Val His Leu Gly Ile Ala His Thr Arg Trp 
                85                  90                  95      


Ala Thr His Gly Glu Pro Ser Pro Val Asn Ser His Pro Gln Arg Ser 
            100                 105                 110         


Asp Lys Asn Asn Glu Phe Ile Val Ile His Asn Gly Ile Ile Thr Asn 
        115                 120                 125             


Tyr Lys Asp Leu Lys Lys Phe Leu Glu Ser Lys Gly Tyr Asp Phe Glu 
    130                 135                 140                 


Ser Glu Thr Asp Thr Glu Thr Ile Ala Lys Leu Val Lys Tyr Met Tyr 
145                 150                 155                 160 


Asp Asn Arg Glu Ser Gln Asp Thr Ser Phe Thr Thr Leu Val Glu Arg 
                165                 170                 175     


Val Ile Gln Gln Leu Glu Gly Ala Phe Ala Leu Val Phe Lys Ser Val 
            180                 185                 190         


His Phe Pro Gly Gln Ala Val Gly Thr Arg Arg Gly Ser Pro Leu Leu 
        195                 200                 205             


Ile Gly Val Arg Ser Glu His Lys Leu Ser Thr Asp His Ile Pro Ile 
    210                 215                 220                 


Leu Tyr Arg Thr Ala Arg Thr Gln Ile Gly Ser Lys Phe Thr Arg Trp 
225                 230                 235                 240 


Gly Ser Gln Gly Glu Arg Gly Lys Asp Lys Lys Gly Ser Cys Asn Leu 
                245                 250                 255     


Ser Arg Val Asp Ser Thr Thr Cys Leu Phe Pro Val Glu Glu Lys Ala 
            260                 265                 270         


Val Glu Tyr Tyr Phe Ala Ser Asp Ala Ser Ala Val Ile Glu His Thr 
        275                 280                 285             


Asn Arg Val Ile Phe Leu Glu Asp Asp Asp Val Ala Ala Val Val Asp 
    290                 295                 300                 


Gly Arg Leu Ser Ile His Arg Ile Lys Arg Thr Ala Gly Asp His Pro 
305                 310                 315                 320 


Gly Arg Ala Val Gln Thr Leu Gln Met Glu Leu Gln Gln Ile Met Lys 
                325                 330                 335     


Gly Asn Phe Ser Ser Phe Met Gln Lys Glu Ile Phe Glu Gln Pro Glu 
            340                 345                 350         


Ser Val Val Asn Thr Met Arg Gly Arg Val Asn Phe Asp Asp Tyr Thr 
        355                 360                 365             


Val Asn Leu Gly Gly Leu Lys Asp His Ile Lys Glu Ile Gln Arg Cys 
    370                 375                 380                 


Arg Arg Leu Ile Leu Ile Ala Cys Gly Thr Ser Tyr His Ala Gly Val 
385                 390                 395                 400 


Ala Thr Arg Gln Val Leu Glu Glu Leu Thr Glu Leu Pro Val Met Val 
                405                 410                 415     


Glu Leu Ala Ser Asp Phe Leu Asp Arg Asn Thr Pro Val Phe Arg Asp 
            420                 425                 430         


Asp Val Cys Phe Phe Leu Ser Gln Ser Gly Glu Thr Ala Asp Thr Leu 
        435                 440                 445             


Met Gly Leu Arg Tyr Cys Lys Glu Arg Gly Ala Leu Thr Val Gly Ile 
    450                 455                 460                 


Thr Asn Thr Val Gly Ser Ser Ile Ser Arg Glu Thr Asp Cys Gly Val 
465                 470                 475                 480 


His Ile Asn Ala Gly Pro Glu Ile Gly Val Ala Ser Thr Lys Ala Tyr 
                485                 490                 495     


Thr Ser Gln Phe Val Ser Leu Val Met Phe Ala Leu Met Met Cys Asp 
            500                 505                 510         


Asp Arg Ile Ser Met Gln Glu Arg Arg Lys Glu Ile Met Leu Gly Leu 
        515                 520                 525             


Lys Arg Leu Pro Asp Leu Ile Lys Glu Val Leu Ser Met Asp Asp Glu 
    530                 535                 540                 


Ile Gln Lys Leu Ala Thr Glu Leu Tyr His Gln Lys Ser Val Leu Ile 
545                 550                 555                 560 


Met Gly Arg Gly Tyr His Tyr Ala Thr Cys Leu Glu Gly Ala Leu Lys 
                565                 570                 575     


Ile Lys Glu Ile Thr Tyr Met His Ser Glu Gly Ile Leu Ala Gly Glu 
            580                 585                 590         


Leu Lys His Gly Pro Leu Ala Leu Val Asp Lys Leu Met Pro Val Ile 
        595                 600                 605             


Met Ile Ile Met Arg Asp His Thr Tyr Ala Lys Cys Gln Asn Ala Leu 
    610                 615                 620                 


Gln Gln Val Val Ala Arg Gln Gly Arg Pro Val Val Ile Cys Asp Lys 
625                 630                 635                 640 


Glu Asp Thr Glu Thr Ile Lys Asn Thr Lys Arg Thr Ile Lys Val Pro 
                645                 650                 655     


His Ser Val Asp Cys Leu Gln Gly Ile Leu Ser Val Ile Pro Leu Gln 
            660                 665                 670         


Leu Leu Ala Phe His Leu Ala Val Leu Arg Gly Tyr Asp Val Asp Phe 
        675                 680                 685             


Pro Arg Asn Leu Ala Lys Ser Val Thr Val Glu 
    690                 695                 


<210> 5926
<211> 688
<212> PRT
<213> Homo sapiens

<400> 5926
Met Ser Val Asn Ser Glu Lys Ser Ser Ser Ser Glu Arg Pro Glu Pro 
1               5                   10                  15      


Gln Gln Lys Ala Pro Leu Val Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Asp Pro Thr Pro Pro Glu Pro Glu Glu Glu 
        35                  40                  45              


Ile Leu Gly Ser Asp Asp Glu Glu Gln Glu Asp Pro Ala Asp Tyr Cys 
    50                  55                  60                  


Lys Gly Gly Tyr His Pro Val Lys Ile Gly Asp Leu Phe Asn Gly Arg 
65                  70                  75                  80  


Tyr His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp 
                85                  90                  95      


Leu Cys Trp Asp Met Gln Gly Lys Arg Phe Val Ala Met Lys Val Val 
            100                 105                 110         


Lys Ser Ala Gln His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Lys Leu 
        115                 120                 125             


Leu Lys Cys Val Arg Glu Ser Asp Pro Ser Asp Pro Asn Lys Asp Met 
    130                 135                 140                 


Val Val Gln Leu Ile Asp Asp Phe Lys Ile Ser Gly Met Asn Gly Ile 
145                 150                 155                 160 


His Val Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp 
                165                 170                 175     


Ile Ile Lys Ser Asn Tyr Gln Gly Leu Pro Val Arg Cys Val Lys Ser 
            180                 185                 190         


Ile Ile Arg Gln Val Leu Gln Gly Leu Asp Tyr Leu His Ser Lys Cys 
        195                 200                 205             


Lys Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Met Cys Val 
    210                 215                 220                 


Asp Asp Ala Tyr Val Arg Arg Met Ala Ala Glu Ala Thr Glu Trp Gln 
225                 230                 235                 240 


Lys Ala Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro 
                245                 250                 255     


Gln Gln Lys Pro Ile Gly Lys Ile Ser Lys Asn Lys Lys Lys Lys Leu 
            260                 265                 270         


Lys Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Leu Gln 
        275                 280                 285             


Glu Ile Glu Glu Leu Glu Arg Glu Ala Glu Arg Lys Ile Ile Glu Glu 
    290                 295                 300                 


Asn Ile Thr Ser Ala Ala Pro Ser Asn Asp Gln Asp Gly Glu Tyr Cys 
305                 310                 315                 320 


Pro Glu Val Lys Leu Lys Thr Thr Gly Leu Glu Glu Ala Ala Glu Ala 
                325                 330                 335     


Glu Thr Ala Lys Asp Asn Gly Glu Ala Glu Asp Gln Glu Glu Lys Glu 
            340                 345                 350         


Asp Ala Glu Lys Glu Asn Ile Glu Lys Asp Glu Asp Asp Val Asp Gln 
        355                 360                 365             


Glu Leu Ala Asn Ile Asp Pro Thr Trp Ile Glu Ser Pro Lys Thr Asn 
    370                 375                 380                 


Gly His Ile Glu Asn Gly Pro Phe Ser Leu Glu Gln Gln Leu Asp Asp 
385                 390                 395                 400 


Glu Asp Asp Asp Glu Glu Asp Cys Pro Asn Pro Glu Glu Tyr Asn Leu 
                405                 410                 415     


Asp Glu Pro Asn Ala Glu Ser Asp Tyr Thr Tyr Ser Ser Ser Tyr Glu 
            420                 425                 430         


Gln Phe Asn Gly Glu Leu Pro Asn Gly Arg His Lys Ile Pro Glu Ser 
        435                 440                 445             


Gln Phe Pro Glu Phe Ser Thr Ser Leu Phe Ser Gly Ser Leu Glu Pro 
    450                 455                 460                 


Val Ala Cys Gly Ser Val Leu Ser Glu Gly Ser Pro Leu Thr Glu Gln 
465                 470                 475                 480 


Glu Glu Ser Ser Pro Ser His Asp Arg Ser Arg Thr Val Ser Ala Ser 
                485                 490                 495     


Ser Thr Gly Asp Leu Pro Lys Ala Lys Thr Arg Ala Ala Asp Leu Leu 
            500                 505                 510         


Val Asn Pro Leu Asp Pro Arg Asn Ala Asp Lys Ile Arg Val Lys Ile 
        515                 520                 525             


Ala Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr Glu Asp 
    530                 535                 540                 


Ile Gln Thr Arg Gln Tyr Arg Ser Ile Glu Val Leu Ile Gly Ala Gly 
545                 550                 555                 560 


Tyr Ser Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu 
                565                 570                 575     


Leu Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly Glu Asp Tyr 
            580                 585                 590         


Ser Arg Asp Glu Asp His Ile Ala His Ile Ile Glu Leu Leu Gly Ser 
        595                 600                 605             


Ile Pro Arg His Phe Ala Leu Ser Gly Lys Tyr Ser Arg Glu Phe Phe 
    610                 615                 620                 


Asn Arg Arg Gly Glu Leu Arg His Ile Thr Lys Leu Lys Pro Trp Ser 
625                 630                 635                 640 


Leu Phe Asp Val Leu Val Glu Lys Tyr Gly Trp Pro His Glu Asp Ala 
                645                 650                 655     


Ala Gln Phe Thr Asp Phe Leu Ile Pro Met Leu Glu Met Val Pro Glu 
            660                 665                 670         


Lys Arg Ala Ser Ala Gly Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
        675                 680                 685             


<210> 5927
<211> 435
<212> PRT
<213> Homo sapiens

<400> 5927
Met Ser Gly Tyr Gln Arg Arg Pro Gly Ala Thr Pro Leu Ser Arg Ala 
1               5                   10                  15      


Arg Ser Leu Ala Ile Pro Asp Ala Pro Ala Phe Tyr Glu Arg Arg Ser 
            20                  25                  30          


Cys Leu Pro Gln Leu Asn Cys Glu Arg Pro His Gly Arg Asp Leu Asp 
        35                  40                  45              


Ser Pro Phe Phe Gly Ile Arg Pro Ala Phe Met Cys Tyr Val Pro Ser 
    50                  55                  60                  


Pro Val Leu Ala Ser Val Gly Asp Thr Asp Phe Gly Tyr Gly Lys Gly 
65                  70                  75                  80  


Lys Cys Ser Lys Gln Ser Pro Ser Gly Ala His Gly Thr His Phe Gly 
                85                  90                  95      


Asp Asp Arg Phe Glu Asp Leu Glu Glu Ala Asn Pro Phe Ser Phe Arg 
            100                 105                 110         


Glu Phe Leu Lys Thr Lys Asn Leu Gly Leu Ser Lys Glu Asp Pro Ala 
        115                 120                 125             


Ser Arg Ile Tyr Ala Lys Glu Ala Ser Arg His Ser Leu Gly Leu Asp 
    130                 135                 140                 


His Asn Ser Pro Pro Ser Gln Thr Gly Gly Tyr Gly Leu Glu Tyr Gln 
145                 150                 155                 160 


Gln Pro Phe Phe Glu Asp Pro Thr Gly Ala Gly Asp Leu Leu Asp Glu 
                165                 170                 175     


Glu Glu Asp Glu Asp Thr Gly Trp Ser Gly Ala Tyr Leu Pro Ser Ala 
            180                 185                 190         


Ile Glu Gln Thr His Pro Glu Arg Val Pro Ala Gly Thr Ser Pro Cys 
        195                 200                 205             


Ser Thr Tyr Leu Ser Phe Phe Ser Thr Pro Ser Glu Leu Ala Gly Pro 
    210                 215                 220                 


Glu Ser Leu Pro Ser Trp Ala Leu Ser Asp Thr Asp Ser Arg Val Ser 
225                 230                 235                 240 


Pro Ala Ser Pro Ala Gly Ser Pro Ser Ala Asp Phe Ala Val His Gly 
                245                 250                 255     


Glu Ser Leu Gly Asp Arg His Leu Arg Thr Leu Gln Ile Ser Tyr Asp 
            260                 265                 270         


Ala Leu Lys Asp Glu Asn Ser Lys Leu Arg Arg Lys Leu Asn Glu Val 
        275                 280                 285             


Gln Ser Phe Ser Glu Ala Gln Thr Glu Met Val Arg Thr Leu Glu Arg 
    290                 295                 300                 


Lys Leu Glu Ala Lys Met Ile Lys Glu Glu Ser Asp Tyr His Asp Leu 
305                 310                 315                 320 


Glu Ser Val Val Gln Gln Val Glu Gln Asn Leu Glu Leu Met Thr Lys 
                325                 330                 335     


Arg Ala Val Lys Ala Glu Asn His Val Val Lys Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Leu Leu Gln Ala Gln Val Ser Asn Phe Gln Arg Glu Asn Glu Ala 
        355                 360                 365             


Leu Arg Cys Gly Gln Gly Ala Ser Leu Thr Val Val Lys Gln Asn Ala 
    370                 375                 380                 


Asp Val Ala Leu Gln Asn Leu Arg Val Val Met Asn Ser Ala Gln Ala 
385                 390                 395                 400 


Ser Ile Lys Gln Leu Val Ser Gly Ala Glu Thr Leu Asn Leu Val Ala 
                405                 410                 415     


Glu Ile Leu Lys Ser Ile Asp Arg Ile Ser Glu Val Lys Asp Glu Glu 
            420                 425                 430         


Glu Asp Ser 
        435 


<210> 5928
<211> 196
<212> PRT
<213> Homo sapiens

<400> 5928
Met Lys Val Lys Ile Lys Cys Trp Asn Gly Val Ala Thr Trp Leu Trp 
1               5                   10                  15      


Val Ala Asn Asp Glu Asn Cys Gly Ile Cys Arg Met Ala Phe Asn Gly 
            20                  25                  30          


Cys Cys Pro Asp Cys Pro Leu His Gly Glu Ser Ile Ser Arg Cys Leu 
        35                  40                  45              


Gly Trp Cys Pro Gln Pro Val Pro Val Leu Gly Gly Arg Ala His Pro 
    50                  55                  60                  


Gln Val Pro Ile Asn Thr Ala Ser Pro Thr Pro Gly Gln His Thr Gly 
65                  70                  75                  80  


Ser Leu Met Ser Arg Glu Glu Ser Ser Arg Ser Pro Asp Pro Thr Pro 
                85                  90                  95      


Pro Ala Leu Asp Gln Glu Thr Ser Ser Leu Leu Arg Cys Thr Ser Pro 
            100                 105                 110         


Trp Cys Leu Asp His Ser Cys Asp Leu Phe Gly Ile Thr Asp Gln Val 
        115                 120                 125             


Ser Ala Asp Gly Pro Arg Ala Cys Arg Gln Gly Ala Arg Arg Arg Leu 
    130                 135                 140                 


Pro Ala Gly Val Gly Pro Val Leu Pro Leu Leu Pro His Ala Leu His 
145                 150                 155                 160 


Pro Gln Val Ala Ala Arg Thr Ala Gly Ala Ala Ala Leu Pro His Val 
                165                 170                 175     


Pro Pro Gly Met Glu Val Gln Gly Val Arg Pro Asp Leu Ala Leu Ala 
            180                 185                 190         


Gly Gly Ala Ser 
        195     


<210> 5929
<211> 1708
<212> PRT
<213> Homo sapiens

<400> 5929
Met Ala Ala Ile Gly Arg Gly Arg Ser Leu Lys Asn Leu Arg Val Arg 
1               5                   10                  15      


Gly Arg Asn Asp Ser Gly Glu Glu Asn Val Pro Leu Asp Leu Thr Arg 
            20                  25                  30          


Glu Pro Ser Asp Asn Leu Arg Glu Ile Leu Gln Asn Val Ala Arg Leu 
        35                  40                  45              


Gln Gly Val Ser Asn Met Arg Lys Leu Gly His Leu Asn Asn Phe Thr 
    50                  55                  60                  


Lys Leu Leu Cys Asp Ile Gly His Ser Glu Glu Lys Leu Gly Phe His 
65                  70                  75                  80  


Tyr Glu Asp Ile Ile Ile Cys Leu Arg Leu Ala Leu Leu Asn Glu Ala 
                85                  90                  95      


Lys Glu Val Arg Ala Ala Gly Leu Arg Ala Leu Arg Tyr Leu Ile Gln 
            100                 105                 110         


Asp Ser Ser Ile Leu Gln Lys Val Leu Lys Leu Lys Val Asp Tyr Leu 
        115                 120                 125             


Ile Ala Arg Cys Ile Asp Ile Gln Gln Ser Asn Glu Val Glu Arg Thr 
    130                 135                 140                 


Gln Ala Leu Arg Leu Val Arg Lys Met Ile Thr Val Asn Ala Ser Leu 
145                 150                 155                 160 


Phe Pro Ser Ser Val Thr Asn Ser Leu Ile Ala Val Gly Asn Asp Gly 
                165                 170                 175     


Leu Gln Glu Arg Asp Arg Met Val Arg Ala Cys Ile Ala Ile Ile Cys 
            180                 185                 190         


Glu Leu Ala Leu Gln Asn Pro Glu Val Val Ala Leu Arg Gly Gly Leu 
        195                 200                 205             


Asn Thr Ile Leu Lys Asn Val Ile Asp Cys Gln Leu Ser Arg Ile Asn 
    210                 215                 220                 


Glu Ala Leu Ile Thr Thr Ile Leu His Leu Leu Asn His Pro Lys Thr 
225                 230                 235                 240 


Arg Gln Tyr Val Arg Ala Asp Val Glu Leu Glu Arg Ile Leu Ala Pro 
                245                 250                 255     


Tyr Thr Asp Phe His Tyr Arg His Ser Pro Asp Thr Ala Glu Gly Gln 
            260                 265                 270         


Leu Lys Glu Asp Arg Glu Ala Arg Phe Leu Ala Ser Lys Met Gly Ile 
        275                 280                 285             


Ile Ala Thr Phe Arg Ser Trp Ala Gly Ile Ile Asn Leu Cys Lys Pro 
    290                 295                 300                 


Gly Asn Ser Gly Ile Gln Ser Leu Ile Gly Val Leu Cys Ile Pro Asn 
305                 310                 315                 320 


Met Glu Ile Arg Arg Gly Leu Leu Glu Val Leu Tyr Asp Ile Phe Arg 
                325                 330                 335     


Leu Pro Leu Pro Val Val Thr Glu Glu Phe Ile Glu Ala Leu Leu Ser 
            340                 345                 350         


Val Asp Pro Gly Arg Phe Gln Asp Ser Trp Arg Leu Ser Asp Gly Phe 
        355                 360                 365             


Val Ala Ala Glu Ala Lys Thr Ile Leu Pro His Arg Ala Arg Ser Arg 
    370                 375                 380                 


Pro Asp Leu Met Asp Asn Tyr Leu Ala Leu Ile Leu Ser Ala Phe Ile 
385                 390                 395                 400 


Arg Asn Gly Leu Leu Glu Gly Leu Val Glu Val Ile Thr Asn Ser Asp 
                405                 410                 415     


Asp His Ile Ser Val Arg Ala Thr Ile Leu Leu Gly Glu Leu Leu His 
            420                 425                 430         


Met Ala Asn Thr Ile Leu Pro His Ser His Ser His His Leu His Cys 
        435                 440                 445             


Leu Pro Thr Leu Met Asn Met Ala Ala Ser Phe Asp Ile Pro Lys Glu 
    450                 455                 460                 


Lys Arg Leu Arg Ala Ser Ala Ala Leu Asn Cys Leu Lys Arg Phe His 
465                 470                 475                 480 


Glu Met Lys Lys Arg Gly Pro Lys Pro Tyr Ser Leu His Leu Asp His 
                485                 490                 495     


Ile Ile Gln Lys Ala Ile Ala Thr His Gln Lys Arg Asp Gln Tyr Leu 
            500                 505                 510         


Arg Val Gln Lys Asp Ile Phe Ile Leu Lys Asp Thr Glu Glu Ala Leu 
        515                 520                 525             


Leu Ile Asn Leu Arg Asp Ser Gln Val Leu Gln His Lys Glu Asn Leu 
    530                 535                 540                 


Glu Trp Asn Trp Asn Leu Ile Gly Thr Ile Leu Lys Trp Pro Asn Val 
545                 550                 555                 560 


Asn Leu Arg Asn Tyr Lys Asp Glu Gln Leu His Arg Phe Val Arg Arg 
                565                 570                 575     


Leu Leu Tyr Phe Tyr Lys Pro Ser Ser Lys Leu Tyr Ala Asn Leu Asp 
            580                 585                 590         


Leu Asp Phe Ala Lys Ala Lys Gln Leu Thr Val Val Gly Cys Gln Phe 
        595                 600                 605             


Thr Glu Phe Leu Leu Glu Ser Glu Glu Asp Gly Gln Gly Tyr Leu Glu 
    610                 615                 620                 


Asp Leu Val Lys Asp Ile Val Gln Trp Leu Asn Ala Ser Ser Gly Met 
625                 630                 635                 640 


Lys Pro Glu Arg Ser Leu Gln Asn Asn Gly Leu Leu Thr Thr Leu Ser 
                645                 650                 655     


Gln His Tyr Phe Leu Phe Ile Gly Thr Leu Ser Cys His Pro His Gly 
            660                 665                 670         


Val Lys Met Leu Glu Lys Cys Ser Val Phe Gln Cys Leu Leu Asn Leu 
        675                 680                 685             


Cys Ser Leu Lys Asn Gln Asp His Leu Leu Lys Leu Thr Val Ser Ser 
    690                 695                 700                 


Leu Asp Tyr Ser Arg Asp Gly Leu Ala Arg Val Ile Leu Ser Lys Ile 
705                 710                 715                 720 


Leu Thr Ala Ala Thr Asp Ala Cys Arg Leu Tyr Ala Thr Lys His Leu 
                725                 730                 735     


Arg Val Leu Leu Arg Ala Asn Val Glu Phe Phe Asn Asn Trp Gly Ile 
            740                 745                 750         


Glu Leu Leu Val Thr Gln Leu His Asp Lys Asn Lys Thr Ile Ser Ser 
        755                 760                 765             


Glu Ala Leu Asp Ile Leu Asp Glu Ala Cys Glu Asp Lys Ala Asn Leu 
    770                 775                 780                 


His Ala Leu Ile Gln Met Lys Pro Ala Leu Ser His Leu Gly Asp Lys 
785                 790                 795                 800 


Gly Leu Leu Leu Leu Leu Arg Phe Leu Ser Ile Pro Lys Gly Phe Ser 
                805                 810                 815     


Tyr Leu Asn Glu Arg Gly Tyr Val Ala Lys Gln Leu Glu Lys Trp His 
            820                 825                 830         


Arg Glu Tyr Asn Ser Lys Tyr Val Asp Leu Ile Glu Glu Gln Leu Asn 
        835                 840                 845             


Glu Ala Leu Thr Thr Tyr Arg Lys Pro Val Asp Gly Asp Asn Tyr Val 
    850                 855                 860                 


Arg Arg Ser Asn Gln Arg Leu Gln Arg Pro His Val Tyr Leu Pro Ile 
865                 870                 875                 880 


His Leu Tyr Gly Gln Leu Val His His Lys Thr Gly Cys His Leu Leu 
                885                 890                 895     


Glu Val Gln Asn Ile Ile Thr Glu Leu Cys Arg Asn Val Arg Thr Pro 
            900                 905                 910         


Asp Leu Asp Lys Trp Glu Glu Ile Lys Lys Leu Lys Ala Ser Leu Trp 
        915                 920                 925             


Ala Leu Gly Asn Ile Gly Ser Ser Asn Trp Gly Leu Asn Leu Leu Gln 
    930                 935                 940                 


Glu Glu Asn Val Ile Pro Asp Ile Leu Lys Leu Ala Lys Gln Cys Glu 
945                 950                 955                 960 


Val Leu Ser Ile Arg Gly Thr Cys Val Tyr Val Leu Gly Leu Ile Ala 
                965                 970                 975     


Lys Thr Lys Gln Gly Cys Asp Ile Leu Lys Cys His Asn Trp Asp Ala 
            980                 985                 990         


Val Arg His Ser Arg Lys His Leu  Trp Pro Val Val Pro  Asp Asp Val 
        995                 1000                 1005             


Glu Gln  Leu Cys Asn Glu Leu  Ser Ser Ile Pro Ser  Thr Leu Ser 
    1010                 1015                 1020             


Leu Asn  Ser Glu Ser Thr Ser  Ser Arg His Asn Ser  Glu Ser Glu 
    1025                 1030                 1035             


Ser Val  Pro Ser Ser Met Phe  Ile Leu Glu Asp Asp  Arg Phe Gly 
    1040                 1045                 1050             


Ser Ser  Ser Thr Ser Thr Phe  Phe Leu Asp Ile Asn  Glu Asp Thr 
    1055                 1060                 1065             


Glu Pro  Thr Phe Tyr Asp Arg  Ser Gly Pro Ile Lys  Asp Lys Asn 
    1070                 1075                 1080             


Ser Phe  Pro Phe Phe Ala Ser  Ser Lys Leu Val Lys  Asn Arg Ile 
    1085                 1090                 1095             


Leu Asn  Ser Leu Thr Leu Pro  Asn Lys Lys His Arg  Ser Ser Ser 
    1100                 1105                 1110             


Asp Pro  Lys Gly Gly Lys Leu  Ser Ser Glu Ser Lys  Thr Ser Asn 
    1115                 1120                 1125             


Arg Arg  Ile Arg Thr Leu Thr  Glu Pro Ser Val Asp  Phe Asn His 
    1130                 1135                 1140             


Ser Asp  Asp Phe Thr Pro Ile  Ser Thr Val Gln Lys  Thr Leu Gln 
    1145                 1150                 1155             


Leu Glu  Thr Ser Phe Met Gly  Asn Lys His Ile Glu  Asp Thr Gly 
    1160                 1165                 1170             


Ser Thr  Pro Ser Ile Gly Glu  Asn Asp Leu Lys Phe  Thr Lys Asn 
    1175                 1180                 1185             


Phe Gly  Thr Glu Asn His Arg  Glu Asn Thr Ser Arg  Glu Arg Leu 
    1190                 1195                 1200             


Val Val  Glu Ser Ser Thr Ser  Ser His Met Lys Ile  Arg Ser Gln 
    1205                 1210                 1215             


Ser Phe  Asn Thr Asp Thr Thr  Thr Ser Gly Ile Ser  Ser Met Ser 
    1220                 1225                 1230             


Ser Ser  Pro Ser Arg Glu Thr  Val Gly Val Asp Ala  Thr Thr Met 
    1235                 1240                 1245             


Asp Thr  Asp Cys Gly Ser Met  Ser Thr Val Val Ser  Thr Lys Thr 
    1250                 1255                 1260             


Ile Lys  Thr Ser His Tyr Leu  Thr Pro Gln Ser Asn  His Leu Ser 
    1265                 1270                 1275             


Leu Ser  Lys Ser Asn Ser Val  Ser Leu Val Pro Pro  Gly Ser Ser 
    1280                 1285                 1290             


His Thr  Leu Pro Arg Arg Ala  Gln Ser Leu Lys Ala  Pro Ser Ile 
    1295                 1300                 1305             


Ala Thr  Ile Lys Ser Leu Ala  Asp Cys Asn Phe Ser  Tyr Thr Ser 
    1310                 1315                 1320             


Ser Arg  Asp Ala Phe Gly Tyr  Ala Thr Leu Lys Arg  Leu Gln Gln 
    1325                 1330                 1335             


Gln Arg  Met His Pro Ser Leu  Ser His Ser Glu Ala  Leu Ala Ser 
    1340                 1345                 1350             


Pro Ala  Lys Asp Val Leu Phe  Thr Asp Thr Ile Thr  Met Lys Ala 
    1355                 1360                 1365             


Asn Ser  Phe Glu Ser Arg Leu  Thr Pro Ser Arg Phe  Met Lys Ala 
    1370                 1375                 1380             


Leu Ser  Tyr Ala Ser Leu Asp  Lys Glu Asp Leu Leu  Ser Pro Ile 
    1385                 1390                 1395             


Asn Gln  Asn Thr Leu Gln Arg  Ser Ser Ser Val Arg  Ser Met Val 
    1400                 1405                 1410             


Ser Ser  Ala Thr Tyr Gly Gly  Ser Asp Asp Tyr Ile  Gly Leu Ala 
    1415                 1420                 1425             


Leu Pro  Val Asp Ile Asn Asp  Ile Phe Gln Val Lys  Asp Ile Pro 
    1430                 1435                 1440             


Tyr Phe  Gln Thr Lys Asn Ile  Pro Pro His Asp Asp  Arg Gly Ala 
    1445                 1450                 1455             


Arg Ala  Phe Ala His Asp Ala  Gly Gly Leu Pro Ser  Gly Thr Gly 
    1460                 1465                 1470             


Gly Leu  Val Lys Asn Ser Phe  His Leu Leu Arg Gln  Gln Met Ser 
    1475                 1480                 1485             


Leu Thr  Glu Ile Met Asn Ser  Ile His Ser Asp Ala  Ser Leu Phe 
    1490                 1495                 1500             


Leu Glu  Ser Thr Glu Asp Thr  Gly Leu Gln Glu His  Thr Asp Asp 
    1505                 1510                 1515             


Asn Cys  Leu Tyr Cys Val Cys  Ile Glu Ile Leu Gly  Phe Gln Pro 
    1520                 1525                 1530             


Ser Asn  Gln Leu Ser Ala Ile  Cys Ser His Ser Asp  Phe Gln Asp 
    1535                 1540                 1545             


Ile Pro  Tyr Ser Asp Trp Cys  Glu Gln Thr Ile His  Asn Pro Leu 
    1550                 1555                 1560             


Glu Val  Val Pro Ser Lys Phe  Ser Gly Ile Ser Gly  Cys Ser Asp 
    1565                 1570                 1575             


Gly Val  Ser Gln Glu Gly Ser  Ala Ser Ser Thr Lys  Ser Thr Glu 
    1580                 1585                 1590             


Leu Leu  Leu Gly Val Lys Thr  Ile Pro Asp Asp Thr  Pro Met Cys 
    1595                 1600                 1605             


Arg Ile  Leu Leu Arg Lys Glu  Val Leu Arg Leu Val  Ile Asn Leu 
    1610                 1615                 1620             


Ser Ser  Ser Val Ser Thr Lys  Cys His Glu Thr Gly  Leu Leu Thr 
    1625                 1630                 1635             


Ile Lys  Glu Lys Tyr Pro Gln  Thr Phe Asp Asp Ile  Cys Leu Tyr 
    1640                 1645                 1650             


Ser Glu  Val Ser His Leu Leu  Ser His Cys Thr Phe  Arg Leu Pro 
    1655                 1660                 1665             


Cys Arg  Arg Phe Ile Gln Glu  Leu Phe Gln Asp Val  Gln Phe Leu 
    1670                 1675                 1680             


Gln Met  His Glu Glu Ala Glu  Ala Val Leu Ala Thr  Pro Pro Lys 
    1685                 1690                 1695             


Gln Pro  Ile Val Asp Thr Ser  Ala Glu Ser 
    1700                 1705             


<210> 5930
<211> 1288
<212> PRT
<213> Homo sapiens

<400> 5930
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu 
                165                 170                 175     


Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp 
            180                 185                 190         


Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp 
        195                 200                 205             


Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg 
    210                 215                 220                 


Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro 
225                 230                 235                 240 


Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp 
                245                 250                 255     


Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg 
            260                 265                 270         


Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Leu Asn Arg Val 
        275                 280                 285             


Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn Ile 
    290                 295                 300                 


Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys Asn 
305                 310                 315                 320 


His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala Glu 
                325                 330                 335     


Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile Asn 
            340                 345                 350         


Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys Asp 
        355                 360                 365             


Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile Glu 
    370                 375                 380                 


Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln Val 
385                 390                 395                 400 


Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Lys Leu Glu Lys 
                405                 410                 415     


Gln Leu Gln Lys Asp Lys Glu Lys Val Glu Glu Phe Lys Ser Ile Pro 
            420                 425                 430         


Ala Lys Ser Asn Asn Ile Ile Asn Glu Thr Thr Thr Arg Asn Asn Ala 
        435                 440                 445             


Leu Glu Lys Glu Lys Glu Lys Glu Glu Lys Lys Leu Lys Glu Val Met 
    450                 455                 460                 


Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu Ser 
465                 470                 475                 480 


Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala Arg 
                485                 490                 495     


Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser Arg 
            500                 505                 510         


His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu Ile 
        515                 520                 525             


Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp Ile 
    530                 535                 540                 


Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu Val 
                565                 570                 575     


His Asp Leu Phe Gln Lys Val Glu Glu Ala Lys Ser Ser Leu Ala Met 
            580                 585                 590         


Asn Arg Ser Arg Gly Lys Val Leu Asp Ala Ile Ile Gln Glu Lys Lys 
        595                 600                 605             


Ser Gly Arg Ile Pro Gly Ile Tyr Gly Arg Leu Gly Asp Leu Gly Ala 
    610                 615                 620                 


Ile Asp Glu Lys Tyr Asp Val Ala Ile Ser Ser Cys Cys His Ala Leu 
625                 630                 635                 640 


Asp Tyr Ile Val Val Asp Ser Ile Asp Ile Ala Gln Glu Cys Val Asn 
                645                 650                 655     


Phe Leu Lys Arg Gln Asn Ile Gly Val Ala Thr Phe Ile Gly Leu Asp 
            660                 665                 670         


Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro Glu 
        675                 680                 685             


Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys Ile 
    690                 695                 700                 


Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp Asn 
705                 710                 715                 720 


Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp Arg 
                725                 730                 735     


Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met Thr 
            740                 745                 750         


Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu Val 
        755                 760                 765             


Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu Gln 
    770                 775                 780                 


Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln Leu 
785                 790                 795                 800 


Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg Asn 
                805                 810                 815     


Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln Glu 
            820                 825                 830         


Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu Ala 
        835                 840                 845             


Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val Ser 
    850                 855                 860                 


Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Gly Lys Val 
865                 870                 875                 880 


Glu Ala Glu Val Lys Arg Leu His Asn Thr Ile Val Glu Ile Asn Asn 
                885                 890                 895     


His Lys Leu Lys Ala Gln Gln Asp Lys Leu Asp Lys Ile Asn Lys Gln 
            900                 905                 910         


Leu Asp Glu Cys Ala Ser Ala Ile Thr Lys Ala Gln Val Ala Ile Lys 
        915                 920                 925             


Thr Ala Asp Arg Asn Leu Gln Lys Ala Gln Asp Ser Val Leu Arg Thr 
    930                 935                 940                 


Glu Lys Glu Ile Lys Asp Thr Glu Lys Glu Val Asp Asp Leu Thr Ala 
945                 950                 955                 960 


Glu Leu Lys Ser Leu Glu Asp Lys Ala Ala Glu Val Val Lys Asn Thr 
                965                 970                 975     


Asn Ala Ala Glu Glu Ser Leu Pro Glu Ile Gln Lys Glu His Arg Asn 
            980                 985                 990         


Leu Leu Gln Glu Leu Lys Val Ile  Gln Glu Asn Glu His  Ala Leu Gln 
        995                 1000                 1005             


Lys Asp  Ala Leu Ser Ile Lys  Leu Lys Leu Glu Gln  Ile Asp Gly 
    1010                 1015                 1020             


His Ile  Ala Glu His Asn Ser  Lys Ile Lys Tyr Trp  His Lys Glu 
    1025                 1030                 1035             


Ile Ser  Lys Ile Ser Leu His  Pro Ile Glu Asp Asn  Pro Ile Glu 
    1040                 1045                 1050             


Glu Ile  Ser Val Leu Ser Pro  Glu Asp Leu Glu Ala  Ile Lys Asn 
    1055                 1060                 1065             


Pro Asp  Ser Ile Thr Asn Gln  Ile Ala Leu Leu Glu  Ala Arg Cys 
    1070                 1075                 1080             


His Glu  Met Lys Pro Asn Leu  Gly Ala Ile Ala Glu  Tyr Lys Lys 
    1085                 1090                 1095             


Lys Glu  Glu Leu Tyr Leu Gln  Arg Val Ala Glu Leu  Asp Lys Ile 
    1100                 1105                 1110             


Thr Tyr  Glu Arg Asp Ser Phe  Arg Gln Ala Tyr Glu  Asp Leu Arg 
    1115                 1120                 1125             


Lys Gln  Arg Leu Asn Glu Phe  Met Ala Gly Phe Tyr  Ile Ile Thr 
    1130                 1135                 1140             


Asn Lys  Leu Lys Glu Asn Tyr  Gln Met Leu Thr Leu  Gly Gly Asp 
    1145                 1150                 1155             


Ala Glu  Leu Glu Leu Val Asp  Ser Leu Asp Pro Phe  Ser Glu Gly 
    1160                 1165                 1170             


Ile Met  Phe Ser Val Arg Pro  Pro Lys Lys Ser Trp  Lys Lys Ile 
    1175                 1180                 1185             


Phe Asn  Leu Ser Gly Gly Glu  Lys Thr Leu Ser Ser  Leu Ala Leu 
    1190                 1195                 1200             


Val Phe  Ala Leu His His Tyr  Lys Pro Thr Pro Leu  Tyr Phe Met 
    1205                 1210                 1215             


Asp Glu  Ile Asp Ala Ala Leu  Asp Phe Lys Asn Val  Ser Ile Val 
    1220                 1225                 1230             


Ala Phe  Tyr Ile Tyr Glu Gln  Thr Lys Asn Ala Gln  Phe Ile Ile 
    1235                 1240                 1245             


Ile Ser  Leu Arg Asn Asn Met  Phe Glu Ile Ser Asp  Arg Leu Ile 
    1250                 1255                 1260             


Gly Ile  Tyr Lys Thr Tyr Asn  Ile Thr Lys Ser Val  Ala Val Asn 
    1265                 1270                 1275             


Pro Lys  Glu Ile Ala Ser Lys  Gly Leu Cys 
    1280                 1285             


<210> 5931
<211> 942
<212> PRT
<213> Homo sapiens

<400> 5931
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg Val 
            100                 105                 110         


Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu Gly 
        115                 120                 125             


Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln Glu 
    130                 135                 140                 


Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys Thr 
145                 150                 155                 160 


Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu Glu 
                165                 170                 175     


Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn 
            180                 185                 190         


Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro 
        195                 200                 205             


Leu Thr Gln Phe Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys 
    210                 215                 220                 


Lys Pro Ala Ile Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp 
225                 230                 235                 240 


His Lys Ser Arg Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly 
                245                 250                 255     


Ile Lys Thr Val Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala 
            260                 265                 270         


Gln Glu Phe Leu Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys 
        275                 280                 285             


Glu Gln Val Met Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu 
    290                 295                 300                 


Glu Thr Met Glu Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser 
305                 310                 315                 320 


Cys Glu Ser Cys Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser 
                325                 330                 335     


Arg Cys Phe Ser Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp 
            340                 345                 350         


Asp Glu Asn Asn Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met 
        355                 360                 365             


Cys Asn Lys Ile Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp 
    370                 375                 380                 


Arg Asp Ser Ile Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val 
385                 390                 395                 400 


Lys Val Gln Ile His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His 
                405                 410                 415     


Ser Asn Asp Leu Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val 
            420                 425                 430         


Asn Pro Arg Leu Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro 
        435                 440                 445             


Gly Leu Ala Pro Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg 
    450                 455                 460                 


Lys Lys Gln His Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp 
465                 470                 475                 480 


Gly Thr Ile Ile Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser 
                485                 490                 495     


Val Thr Leu Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys 
            500                 505                 510         


Glu Asp Leu Ala Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val 
        515                 520                 525             


Lys Ala Gly Ser Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala 
    530                 535                 540                 


Phe Phe Met Glu Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser 
545                 550                 555                 560 


Trp Phe Trp Gly Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe 
                565                 570                 575     


Phe Ala Arg Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys 
            580                 585                 590         


Cys Lys Lys Leu Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe 
        595                 600                 605             


Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met 
    610                 615                 620                 


Phe Ser Thr Lys Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu 
625                 630                 635                 640 


Asp Leu Gln Pro Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr 
                645                 650                 655     


Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly 
            660                 665                 670         


His Tyr Ile Ala Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu 
        675                 680                 685             


Phe Asp Asp Gln Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn 
    690                 695                 700                 


Ala Glu Ala Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala Gln 
705                 710                 715                 720 


Lys Glu Arg Arg Arg Ile Ser Asn Leu Leu Asn Ile Met Glu Pro Ser 
                725                 730                 735     


Leu Leu Gln Phe Tyr Ile Ser Arg Gln Trp Leu Asn Lys Phe Lys Thr 
            740                 745                 750         


Phe Ala Glu Pro Gly Pro Ile Ser Asn Asn Asp Phe Leu Cys Ile His 
        755                 760                 765             


Gly Gly Val Pro Pro Arg Lys Ala Gly Tyr Ile Glu Asp Leu Val Leu 
    770                 775                 780                 


Met Leu Pro Gln Asn Ile Trp Asp Asn Leu Tyr Ser Arg Tyr Gly Gly 
785                 790                 795                 800 


Gly Pro Ala Val Asn His Leu Tyr Ile Cys His Thr Cys Gln Ile Glu 
                805                 810                 815     


Ala Glu Lys Ile Glu Lys Arg Arg Lys Thr Glu Leu Glu Ile Phe Ile 
            820                 825                 830         


Arg Leu Asn Arg Ala Phe Gln Lys Glu Asp Ser Pro Ala Thr Phe Tyr 
        835                 840                 845             


Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ser Phe Val Lys Gly 
    850                 855                 860                 


Lys Asp Gly Asp Pro Pro Gly Pro Ile Asp Asn Thr Lys Ile Ala Val 
865                 870                 875                 880 


Thr Lys Cys Gly Asn Val Met Leu Arg Gln Gly Ala Asp Ser Gly Gln 
                885                 890                 895     


Ile Ser Glu Glu Thr Trp Asn Phe Leu Gln Ser Ile Tyr Gly Gly Gly 
            900                 905                 910         


Pro Glu Val Ile Leu Arg Pro Pro Val Val His Val Asp Pro Asp Ile 
        915                 920                 925             


Leu Gln Ala Glu Glu Lys Ile Glu Val Glu Thr Arg Ser Leu 
    930                 935                 940         


<210> 5932
<211> 701
<212> PRT
<213> Homo sapiens

<400> 5932
Met Met Lys Arg Gln Leu His Arg Met Arg Gln Leu Ala Gln Thr Gly 
1               5                   10                  15      


Ser Leu Gly Arg Thr Pro Glu Thr Ala Glu Phe Leu Gly Glu Asp Leu 
            20                  25                  30          


Leu Gln Val Glu Gln Arg Leu Glu Pro Ala Lys Arg Ala Ala His Asn 
        35                  40                  45              


Ile His Lys Arg Leu Gln Ala Cys Leu Gln Gly Gln Ser Gly Ala Asp 
    50                  55                  60                  


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
65                  70                  75                  80  


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
                85                  90                  95      


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
            100                 105                 110         


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
        115                 120                 125             


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
    130                 135                 140                 


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
145                 150                 155                 160 


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
                165                 170                 175     


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
            180                 185                 190         


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
        195                 200                 205             


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
    210                 215                 220                 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
225                 230                 235                 240 


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
                245                 250                 255     


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
            260                 265                 270         


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
        275                 280                 285             


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
    290                 295                 300                 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
305                 310                 315                 320 


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
                325                 330                 335     


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
            340                 345                 350         


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
        355                 360                 365             


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
    370                 375                 380                 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
385                 390                 395                 400 


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
                405                 410                 415     


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
            420                 425                 430         


Trp Pro Pro Glu Lys Glu Gly Asp Gln Ala Gln Leu Asp Ala Ala Ser 
        435                 440                 445             


Val Ser Ser Ile Gln Val Val Gly Val Val Glu Ala Leu Ile Gln Ser 
    450                 455                 460                 


Ala Asp Thr Leu Phe Pro Gly Asp Ile Asn Phe Asn Val Ser Gly Leu 
465                 470                 475                 480 


Phe Ser Ala Val Thr Leu Gln Asp Thr Val Ser Asp Arg Leu Ala Ser 
                485                 490                 495     


Glu Glu Leu Pro Ser Thr Ala Val Pro Thr Pro Ala Thr Thr Pro Ala 
            500                 505                 510         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Leu Ala Ser Ala 
        515                 520                 525             


Ala Thr Lys Glu Arg Thr Glu Ser Glu Val Pro Pro Arg Pro Ala Ser 
    530                 535                 540                 


Pro Lys Val Thr Arg Ser Pro Pro Glu Thr Ala Ala Pro Val Glu Asp 
545                 550                 555                 560 


Met Ala Arg Arg Thr Lys Arg Pro Ala Pro Ala Arg Pro Thr Met Pro 
                565                 570                 575     


Pro Pro Gln Val Ser Gly Ser Arg Ser Ser Pro Pro Ala Pro Pro Leu 
            580                 585                 590         


Pro Pro Gly Ser Gly Ser Pro Gly Thr Pro Gln Ala Leu Pro Arg Arg 
        595                 600                 605             


Leu Val Gly Ser Ser Leu Arg Ala Pro Thr Val Pro Pro Pro Leu Pro 
    610                 615                 620                 


Pro Thr Pro Pro Gln Pro Ala Arg Arg Gln Ser Arg Arg Ser Pro Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Ala Ser Pro Gly Pro Ala Ser Pro Ser Pro Val Ser 
                645                 650                 655     


Leu Ser Asn Pro Ala Gln Val Asp Leu Gly Ala Ala Thr Ala Glu Gly 
            660                 665                 670         


Gly Ala Pro Glu Ala Ile Ser Gly Val Pro Thr Pro Pro Ala Ile Pro 
        675                 680                 685             


Pro Gln Pro Arg Pro Arg Ser Leu Ala Ser Glu Thr Asn 
    690                 695                 700     


<210> 5933
<211> 605
<212> PRT
<213> Homo sapiens

<400> 5933
Met Glu Val Arg Ala Ser Leu Gln Lys Ile Val Ser Asn Gly Asp Glu 
1               5                   10                  15      


Gln Leu Glu Lys Ala Met Glu Glu Ile Leu Arg Asp Ser Glu Lys Arg 
            20                  25                  30          


Pro Ser Ser Leu Leu Val Asp Cys Gln Ser Ser Ser Glu Ile Ser Asp 
        35                  40                  45              


His Ser Phe Gly Asp Ile Pro Ala Ser Gln Thr Asn Lys Pro Ser Leu 
    50                  55                  60                  


Gln Leu Ile Leu Asp Pro Ser Asn Thr Glu Ile Ser Thr Pro Arg Pro 
65                  70                  75                  80  


Ser Ser Pro Gly Gly Leu Pro Glu Glu Asp Ser Val Leu Phe Asn Lys 
                85                  90                  95      


Leu Thr Tyr Leu Gly Cys Met Lys Val Ser Ser Pro Arg Asn Glu Val 
            100                 105                 110         


Glu Ala Leu Arg Ala Met Ala Thr Met Lys Ser Ser Ser Gln Tyr Pro 
        115                 120                 125             


Phe Pro Val Thr Leu Tyr Val Pro Asn Val Pro Glu Gly Ser Val Arg 
    130                 135                 140                 


Ile Ile Asp Gln Ser Ser Asn Val Glu Ile Ala Ser Phe Pro Ile Tyr 
145                 150                 155                 160 


Lys Val Leu Phe Cys Ala Arg Gly His Asp Gly Thr Thr Glu Ser Asn 
                165                 170                 175     


Cys Phe Ala Phe Thr Glu Ser Ser His Gly Ser Glu Glu Phe Gln Ile 
            180                 185                 190         


His Val Phe Ser Cys Glu Ile Lys Glu Ala Val Ser Arg Ile Leu Tyr 
        195                 200                 205             


Ser Phe Cys Thr Ala Phe Lys Arg Ser Ser Arg Gln Val Ser Asp Val 
    210                 215                 220                 


Lys Asp Ser Val Ile Pro Thr Pro Asp Ser Asp Val Phe Thr Phe Ser 
225                 230                 235                 240 


Val Ser Leu Glu Val Lys Glu Asp Asp Gly Lys Gly Asn Phe Ser Pro 
                245                 250                 255     


Val Pro Lys Asp Arg Asp Lys Phe Tyr Phe Lys Leu Lys Gln Gly Ile 
            260                 265                 270         


Glu Lys Lys Val Val Ile Thr Val Gln Gln Leu Ser Asn Lys Glu Leu 
        275                 280                 285             


Ala Ile Glu Arg Cys Phe Gly Met Leu Leu Ser Pro Gly Arg Asn Val 
    290                 295                 300                 


Lys Asn Ser Asp Met His Leu Leu Asp Met Glu Ser Met Gly Lys Ser 
305                 310                 315                 320 


Tyr Asp Gly Arg Ala Tyr Val Ile Thr Gly Met Trp Asn Pro Asn Ala 
                325                 330                 335     


Pro Val Phe Leu Ala Leu Asn Glu Glu Thr Pro Lys Asp Lys Gln Val 
            340                 345                 350         


Tyr Met Thr Val Ala Val Asp Met Val Val Thr Glu Val Val Glu Pro 
        355                 360                 365             


Val Arg Phe Leu Leu Glu Thr Val Val Arg Val Tyr Pro Ala Asn Glu 
    370                 375                 380                 


Arg Phe Trp Tyr Phe Ser Arg Lys Thr Phe Thr Glu Thr Phe Phe Met 
385                 390                 395                 400 


Arg Leu Lys Gln Ser Glu Gly Lys Gly His Thr Asn Ala Gly Asp Ala 
                405                 410                 415     


Ile Tyr Glu Val Val Ser Leu Gln Arg Glu Ser Asp Lys Glu Glu Pro 
            420                 425                 430         


Val Thr Pro Thr Ser Gly Gly Gly Pro Met Ser Pro Gln Asp Asp Glu 
        435                 440                 445             


Ala Glu Glu Glu Ser Asp Asn Glu Leu Ser Ser Gly Thr Gly Asp Val 
    450                 455                 460                 


Ser Lys Asp Cys Pro Glu Lys Ile Leu Tyr Ser Trp Gly Glu Leu Leu 
465                 470                 475                 480 


Gly Lys Trp His Ser Asn Leu Gly Ala Arg Pro Lys Gly Leu Ser Thr 
                485                 490                 495     


Leu Val Lys Ser Gly Val Pro Glu Ala Leu Arg Ala Glu Val Trp Gln 
            500                 505                 510         


Leu Leu Ala Gly Cys His Asp Asn Gln Ala Met Leu Asp Arg Tyr Arg 
        515                 520                 525             


Ile Leu Ile Thr Lys Gln Gln Met Lys Phe Ser Leu Thr Pro Arg Gln 
    530                 535                 540                 


Thr Ile His Leu Val Lys Tyr Glu Gly Ser Met Lys Val Ser Met Thr 
545                 550                 555                 560 


Pro Cys Asn Gln Leu Gln Phe Asp Ile Arg Leu Asp Val Leu Ile Thr 
                565                 570                 575     


Tyr Thr Phe Cys Phe Ser Ser Phe Pro Glu Pro Glu Leu Tyr Lys Tyr 
            580                 585                 590         


Val Leu Lys His Gln Leu Ile Lys Arg Leu Asn Ala Cys 
        595                 600                 605 


<210> 5934
<211> 1039
<212> PRT
<213> Homo sapiens

<400> 5934
Met Ala Val Gln Leu Val Pro Asp Ser Ala Leu Gly Leu Leu Met Met 
1               5                   10                  15      


Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys Leu 
            20                  25                  30          


Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp Leu 
        35                  40                  45              


Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Ala 
    50                  55                  60                  


Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg Arg 
65                  70                  75                  80  


Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu Tyr 
                85                  90                  95      


Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp Asn 
            100                 105                 110         


Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr Lys 
        115                 120                 125             


Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser Tyr 
    130                 135                 140                 


Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val Arg 
145                 150                 155                 160 


Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys Glu 
                165                 170                 175     


His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr Lys 
            180                 185                 190         


Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met Ser 
        195                 200                 205             


Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val Lys 
    210                 215                 220                 


Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly Ile 
225                 230                 235                 240 


Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe Gln 
                245                 250                 255     


Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser Val 
            260                 265                 270         


Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe Gly 
        275                 280                 285             


His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu Ile 
    290                 295                 300                 


Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp 
305                 310                 315                 320 


Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser Glu 
                325                 330                 335     


Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys Leu 
            340                 345                 350         


Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly Ser 
        355                 360                 365             


Leu Leu Ser Ser Gly Ser Gln Glu Ser Asp Ser Ser Gln Ser Ala Lys 
    370                 375                 380                 


Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gln Glu Ala Leu Glu Glu 
385                 390                 395                 400 


Thr Leu Arg Gln Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu Arg Glu 
                405                 410                 415     


Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro Leu Asp Pro Gly 
            420                 425                 430         


Glu Glu Pro Pro Ile Val Arg Arg Arg Ile Gly Thr Ala Phe Lys Leu 
        435                 440                 445             


Asp Glu Gln Lys Ile Leu Pro Lys Gly Glu Glu Ala Glu Leu Glu Arg 
    450                 455                 460                 


Leu Glu Arg Glu Phe Ala Ile Gln Ser Gln Ile Thr Glu Ala Ala Arg 
465                 470                 475                 480 


Arg Leu Ala Ser Asp Pro Asn Val Ser Lys Lys Leu Lys Lys Gln Arg 
                485                 490                 495     


Lys Thr Ser Tyr Leu Asn Ala Leu Lys Lys Leu Gln Glu Ile Glu Asn 
            500                 505                 510         


Ala Ile Asn Glu Asn Arg Ile Lys Ser Gly Lys Lys Pro Thr Gln Arg 
        515                 520                 525             


Ala Ser Leu Ile Ile Asp Asp Gly Asn Ile Ala Ser Glu Asp Ser Ser 
    530                 535                 540                 


Leu Ser Asp Ala Leu Val Leu Glu Asp Glu Asp Ser Gln Val Thr Ser 
545                 550                 555                 560 


Thr Ile Ser Pro Leu His Ser Pro His Lys Gly Leu Pro Pro Arg Pro 
                565                 570                 575     


Pro Ser His Asn Arg Pro Pro Pro Pro Gln Ser Leu Glu Gly Leu Arg 
            580                 585                 590         


Gln Met His Tyr His Arg Asn Asp Tyr Asp Lys Ser Pro Ile Lys Pro 
        595                 600                 605             


Lys Met Trp Ser Glu Ser Ser Leu Asp Glu Pro Tyr Glu Lys Val Lys 
    610                 615                 620                 


Lys Arg Ser Ser His Ser His Ser Ser Ser His Lys Arg Phe Pro Ser 
625                 630                 635                 640 


Thr Gly Ser Cys Ala Glu Ala Gly Gly Gly Ser Asn Ser Leu Gln Asn 
                645                 650                 655     


Ser Pro Ile Arg Gly Leu Pro His Trp Asn Ser Gln Ser Ser Met Pro 
            660                 665                 670         


Ser Thr Pro Asp Leu Arg Val Arg Ser Pro His Tyr Val His Ser Thr 
        675                 680                 685             


Arg Ser Val Asp Ile Ser Pro Thr Arg Leu His Ser Leu Ala Leu His 
    690                 695                 700                 


Phe Arg His Arg Ser Ser Ser Leu Glu Ser Gln Gly Lys Leu Leu Gly 
705                 710                 715                 720 


Ser Glu Asn Asp Thr Gly Ser Pro Asp Phe Tyr Thr Pro Arg Thr Arg 
                725                 730                 735     


Ser Ser Asn Gly Ser Asp Pro Met Asp Asp Cys Ser Ser Cys Thr Ser 
            740                 745                 750         


His Ser Ser Ser Glu His Tyr Tyr Pro Ala Gln Met Asn Ala Asn Tyr 
        755                 760                 765             


Ser Thr Leu Ala Glu Asp Ser Pro Ser Lys Ala Arg Gln Arg Gln Arg 
    770                 775                 780                 


Gln Arg Gln Arg Ala Ala Gly Ala Leu Gly Ser Ala Ser Ser Gly Ser 
785                 790                 795                 800 


Met Pro Asn Leu Ala Ala Arg Gly Gly Ala Gly Gly Ala Gly Gly Ala 
                805                 810                 815     


Gly Gly Gly Val Tyr Leu His Ser Gln Ser Gln Pro Ser Ser Gln Tyr 
            820                 825                 830         


Arg Ile Lys Glu Tyr Pro Leu Tyr Ile Glu Gly Gly Ala Thr Pro Val 
        835                 840                 845             


Val Val Arg Ser Leu Glu Ser Asp Gln Glu Gly His Tyr Ser Val Lys 
    850                 855                 860                 


Ala Gln Phe Lys Thr Ser Asn Ser Tyr Thr Ala Gly Gly Leu Phe Lys 
865                 870                 875                 880 


Glu Ser Trp Arg Gly Gly Gly Gly Asp Glu Gly Asp Thr Gly Arg Leu 
                885                 890                 895     


Thr Pro Ser Arg Ser Gln Ile Leu Arg Thr Pro Ser Leu Gly Arg Glu 
            900                 905                 910         


Gly Ala His Asp Lys Gly Ala Gly Arg Ala Ala Val Ser Asp Glu Leu 
        915                 920                 925             


Arg Gln Trp Tyr Gln Arg Ser Thr Ala Ser His Lys Glu His Ser Arg 
    930                 935                 940                 


Leu Ser His Thr Ser Ser Thr Ser Ser Asp Ser Gly Ser Gln Tyr Ser 
945                 950                 955                 960 


Thr Ser Ser Gln Ser Thr Phe Val Ala His Ser Arg Val Thr Arg Met 
                965                 970                 975     


Pro Gln Met Cys Lys Ala Thr Ser Ala Ala Leu Pro Gln Ser Gln Arg 
            980                 985                 990         


Ser Ser Thr Pro Ser Ser Glu Ile  Gly Ala Thr Pro Pro  Ser Ser Pro 
        995                 1000                 1005             


His His  Ile Leu Thr Trp Gln  Thr Gly Glu Ala Thr  Glu Asn Ser 
    1010                 1015                 1020             


Pro Ile  Leu Asp Gly Ser Glu  Ser Pro Pro His Gln  Ser Thr Asp 
    1025                 1030                 1035             


Glu 
    


<210> 5935
<211> 1075
<212> PRT
<213> Homo sapiens

<400> 5935
Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Cys Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Ser Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Ser Leu Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu 
    370                 375                 380                 


Glu Glu Ser Gln Arg Phe Lys Gly Ser Glu Asn Ser Gln Pro Glu Lys 
385                 390                 395                 400 


Met Ser Gln Glu Pro Glu Ile Asn Lys Asp Gly Asp Arg Glu Val Glu 
                405                 410                 415     


Glu Glu Met Lys Lys His Glu Ser Asn Asn Val Gly Leu Leu Glu Asn 
            420                 425                 430         


Leu Thr Asn Gly Val Thr Ala Gly Asn Gly Asp Asn Gly Leu Ile Pro 
        435                 440                 445             


Gln Arg Lys Ser Arg Thr Pro Glu Asn Gln Gln Phe Pro Asp Asn Glu 
    450                 455                 460                 


Ser Glu Glu Tyr His Arg Ile Cys Glu Leu Leu Ser Asp Tyr Lys Glu 
465                 470                 475                 480 


Lys Gln Met Pro Lys Tyr Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp 
                485                 490                 495     


Leu Lys Leu Thr Ser Glu Glu Glu Ser Gln Arg Leu Lys Gly Ser Glu 
            500                 505                 510         


Asn Gly Gln Pro Glu Lys Arg Ser Gln Glu Pro Glu Ile Asn Lys Asp 
        515                 520                 525             


Gly Asp Arg Glu Leu Glu Asn Phe Met Ala Ile Glu Glu Met Lys Lys 
    530                 535                 540                 


His Arg Ser Thr His Val Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala 
545                 550                 555                 560 


Thr Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg 
                565                 570                 575     


Thr Pro Glu Ser Gln Gln Phe Pro Asp Thr Glu Asn Glu Glu Tyr His 
            580                 585                 590         


Ser Asp Glu Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn 
        595                 600                 605             


Thr Gly Ile Leu His Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile 
    610                 615                 620                 


Glu Val Val Glu Lys Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys 
625                 630                 635                 640 


Glu Lys Asp Ile Leu His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala 
                645                 650                 655     


Met Leu Arg Leu Glu Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg 
            660                 665                 670         


Glu Lys Lys Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys Arg Asn Asp 
        675                 680                 685             


Asn Leu Leu Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp 
    690                 695                 700                 


Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly 
705                 710                 715                 720 


Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly 
                725                 730                 735     


Arg Pro Arg Gln Gln Gly Met Met Gly Gly Met His Gln Lys Glu Ser 
            740                 745                 750         


Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys 
        755                 760                 765             


Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys 
    770                 775                 780                 


Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu 
785                 790                 795                 800 


His Pro Val Leu Leu Thr Glu Ala Thr Leu Asn Pro Lys Ala Asn Arg 
                805                 810                 815     


Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met 
            820                 825                 830         


Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Thr Ser Gly Arg Thr 
        835                 840                 845             


Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro 
    850                 855                 860                 


Ile Tyr Glu Gly Asn Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu 
865                 870                 875                 880 


Ala Gly Arg Glu Leu Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu His 
                885                 890                 895     


Gly Tyr Arg Phe Thr Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile 
            900                 905                 910         


Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala 
        915                 920                 925             


Thr Val Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp 
    930                 935                 940                 


Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala 
945                 950                 955                 960 


Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu 
                965                 970                 975     


Thr Thr Phe Asn Ser Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp 
            980                 985                 990         


Leu Tyr Thr Asn Thr Val Leu Ser  Gly Gly Thr Thr Met  Tyr Pro Gly 
        995                 1000                 1005             


Met Ala  His Arg Met Gln Lys  Glu Ile Ala Ala Leu  Ala Pro Ser 
    1010                 1015                 1020             


Met Met  Lys Ile Arg Ile Ile  Ala Pro Pro Lys Arg  Lys Tyr Ser 
    1025                 1030                 1035             


Val Trp  Val Gly Gly Ser Ile  Leu Ala Ser Leu Ser  Thr Phe Gln 
    1040                 1045                 1050             


Gln Met  Trp Ile Ser Lys Gln  Glu Tyr Asp Glu Ser  Gly Pro Ser 
    1055                 1060                 1065             


Ile Val  His Arg Lys Cys Leu  
    1070                 1075 


<210> 5936
<211> 583
<212> PRT
<213> Homo sapiens

<400> 5936
Met Leu Ser Glu Ser Lys Glu Gly Glu Glu Lys Glu Glu Val Thr Met 
1               5                   10                  15      


Asp Thr Ser Glu Asn Arg Pro Glu Asn Asp Val Pro Glu Pro Pro Met 
            20                  25                  30          


Pro Ile Ala Asp Gln Val Ser Asn Asp Asp Arg Pro Glu Gly Ser Val 
        35                  40                  45              


Glu Asp Glu Glu Lys Lys Glu Ser Ser Leu Pro Lys Ser Phe Lys Arg 
    50                  55                  60                  


Lys Ile Ser Val Val Ser Ala Thr Lys Gly Val Pro Ala Gly Asn Ser 
65                  70                  75                  80  


Asp Thr Glu Gly Gly Gln Pro Gly Arg Lys Arg Arg Trp Gly Ala Ser 
                85                  90                  95      


Thr Ala Thr Thr Gln Lys Lys Pro Ser Ile Ser Ile Thr Thr Glu Ser 
            100                 105                 110         


Leu Lys Ser Leu Ile Pro Asp Ile Lys Pro Leu Ala Gly Gln Glu Ala 
        115                 120                 125             


Val Val Asp Leu His Ala Asp Asp Ser Arg Ile Ser Glu Asp Glu Thr 
    130                 135                 140                 


Glu Arg Asn Gly Asp Asp Gly Thr His Asp Lys Gly Leu Lys Ile Cys 
145                 150                 155                 160 


Arg Thr Val Thr Gln Val Val Pro Ala Glu Gly Gln Glu Asn Gly Gln 
                165                 170                 175     


Arg Glu Glu Glu Glu Glu Glu Lys Glu Pro Glu Ala Glu Pro Pro Val 
            180                 185                 190         


Pro Pro Gln Val Ser Val Glu Val Ala Leu Pro Pro Pro Ala Glu His 
        195                 200                 205             


Glu Val Lys Lys Val Thr Leu Gly Asp Thr Leu Thr Arg Arg Ser Ile 
    210                 215                 220                 


Ser Gln Gln Lys Ser Gly Val Ser Ile Thr Ile Asp Asp Pro Val Arg 
225                 230                 235                 240 


Thr Ala Gln Val Pro Ser Pro Pro Arg Gly Lys Ile Ser Asn Ile Val 
                245                 250                 255     


His Ile Ser Asn Leu Val Arg Pro Phe Thr Leu Gly Gln Leu Lys Glu 
            260                 265                 270         


Leu Leu Gly Arg Thr Gly Thr Leu Val Glu Glu Ala Phe Trp Ile Asp 
        275                 280                 285             


Lys Ile Lys Ser His Cys Phe Val Thr Tyr Ser Thr Val Glu Glu Ala 
    290                 295                 300                 


Val Ala Thr Arg Thr Ala Leu His Gly Val Lys Trp Pro Gln Ser Asn 
305                 310                 315                 320 


Pro Lys Phe Leu Cys Ala Asp Tyr Ala Glu Gln Asp Glu Leu Asp Tyr 
                325                 330                 335     


His Arg Gly Leu Leu Val Asp Arg Pro Ser Glu Thr Lys Thr Glu Glu 
            340                 345                 350         


Gln Gly Ile Pro Arg Pro Leu His Pro Pro Pro Pro Pro Pro Val Gln 
        355                 360                 365             


Pro Pro Gln His Pro Arg Ala Glu Gln Arg Glu Gln Glu Arg Ala Val 
    370                 375                 380                 


Arg Glu Gln Trp Ala Glu Arg Glu Arg Glu Met Glu Arg Arg Glu Arg 
385                 390                 395                 400 


Thr Arg Ser Glu Arg Glu Trp Asp Arg Asp Lys Val Arg Glu Gly Pro 
                405                 410                 415     


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Arg Lys Glu Arg Ala Lys 
            420                 425                 430         


Ser Lys Glu Lys Lys Ser Glu Lys Lys Glu Lys Ala Gln Glu Glu Pro 
        435                 440                 445             


Pro Ala Lys Leu Leu Asp Asp Leu Phe Arg Lys Thr Lys Ala Ala Pro 
    450                 455                 460                 


Cys Ile Tyr Trp Leu Pro Leu Thr Asp Ser Gln Ile Val Gln Lys Glu 
465                 470                 475                 480 


Ala Glu Arg Ala Glu Arg Ala Lys Glu Arg Glu Lys Arg Arg Lys Glu 
                485                 490                 495     


Gln Glu Glu Glu Glu Gln Lys Glu Arg Glu Lys Glu Ala Glu Arg Glu 
            500                 505                 510         


Arg Asn Arg Gln Leu Glu Arg Glu Lys Arg Arg Glu His Ser Arg Glu 
        515                 520                 525             


Arg Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg Gly Asp Arg 
    530                 535                 540                 


Asp Arg Asp Arg Glu Arg Asp Arg Glu Arg Gly Arg Glu Arg Asp Arg 
545                 550                 555                 560 


Arg Asp Thr Lys Arg His Ser Arg Ser Arg Ser Arg Ser Thr Pro Val 
                565                 570                 575     


Arg Asp Arg Gly Gly Arg Arg 
            580             


<210> 5937
<211> 320
<212> PRT
<213> Homo sapiens

<400> 5937
Met Ser Lys Ser Ala Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Thr Thr Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Lys Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Pro Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Arg Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Asp 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Cys Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Val Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210> 5938
<211> 1097
<212> PRT
<213> Homo sapiens

<400> 5938
Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu Leu Gly 
1               5                   10                  15      


Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu Glu Thr 
            20                  25                  30          


Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu Gln Ala 
        35                  40                  45              


Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala Ala Val 
    50                  55                  60                  


Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr Pro Ala 
65                  70                  75                  80  


Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser Glu Leu Leu Met Ile 
                85                  90                  95      


Ile Gln Met Glu Thr Gln Ser Ser Met Arg Lys Lys Val Cys Asp Ile 
            100                 105                 110         


Ala Ala Glu Leu Ala Arg Asn Leu Ile Asp Glu Asp Gly Asn Asn Gln 
        115                 120                 125             


Trp Pro Glu Gly Leu Lys Phe Leu Phe Asp Ser Val Ser Ser Gln Asn 
    130                 135                 140                 


Val Gly Leu Arg Glu Ala Ala Leu His Ile Phe Trp Asn Phe Pro Gly 
145                 150                 155                 160 


Ile Phe Gly Asn Gln Gln Gln His Tyr Leu Asp Val Ile Lys Arg Met 
                165                 170                 175     


Leu Val Gln Cys Met Gln Asp Gln Glu His Pro Ser Ile Arg Thr Leu 
            180                 185                 190         


Ser Ala Arg Ala Thr Ala Ala Phe Ile Leu Ala Asn Glu His Asn Val 
        195                 200                 205             


Ala Leu Phe Lys His Phe Ala Asp Leu Leu Pro Gly Phe Leu Gln Ala 
    210                 215                 220                 


Val Asn Asp Ser Cys Tyr Gln Asn Asp Asp Ser Val Leu Lys Ser Leu 
225                 230                 235                 240 


Val Glu Ile Ala Asp Thr Val Pro Lys Tyr Leu Arg Pro His Leu Glu 
                245                 250                 255     


Ala Thr Leu Gln Leu Ser Leu Lys Leu Cys Gly Asp Thr Ser Leu Asn 
            260                 265                 270         


Asn Met Gln Arg Gln Leu Ala Leu Glu Val Ile Val Thr Leu Ser Glu 
        275                 280                 285             


Thr Ala Ala Ala Met Leu Arg Lys His Thr Asn Ile Val Ala Gln Thr 
    290                 295                 300                 


Ile Pro Gln Met Leu Ala Met Met Val Asp Leu Glu Glu Asp Glu Asp 
305                 310                 315                 320 


Trp Ala Asn Ala Asp Glu Leu Glu Asp Asp Asp Phe Asp Ser Asn Ala 
                325                 330                 335     


Val Ala Gly Glu Ser Ala Leu Asp Arg Met Ala Cys Gly Leu Gly Gly 
            340                 345                 350         


Lys Leu Val Leu Pro Met Ile Lys Glu His Ile Met Gln Met Leu Gln 
        355                 360                 365             


Asn Pro Asp Trp Lys Tyr Arg His Ala Gly Leu Met Ala Leu Ser Ala 
    370                 375                 380                 


Ile Gly Glu Gly Cys His Gln Gln Met Glu Gly Ile Leu Asn Glu Ile 
385                 390                 395                 400 


Val Asn Phe Val Leu Leu Phe Leu Gln Asp Pro His Pro Arg Val Arg 
                405                 410                 415     


Tyr Ala Ala Cys Asn Ala Val Gly Gln Met Ala Thr Asp Phe Ala Pro 
            420                 425                 430         


Gly Phe Gln Lys Lys Phe His Glu Lys Val Ile Ala Ala Leu Leu Gln 
        435                 440                 445             


Thr Met Glu Asp Gln Gly Asn Gln Arg Val Gln Ala His Ala Ala Ala 
    450                 455                 460                 


Ala Leu Ile Asn Phe Thr Glu Asp Cys Pro Lys Ser Leu Leu Ile Pro 
465                 470                 475                 480 


Tyr Leu Asp Asn Leu Val Lys His Leu His Ser Ile Met Val Leu Lys 
                485                 490                 495     


Leu Gln Glu Leu Ile Gln Lys Gly Thr Lys Leu Val Leu Glu Gln Val 
            500                 505                 510         


Val Thr Ser Ile Ala Ser Val Ala Asp Thr Ala Glu Glu Lys Phe Val 
        515                 520                 525             


Pro Tyr Tyr Asp Leu Phe Met Pro Ser Leu Lys His Ile Val Glu Asn 
    530                 535                 540                 


Ala Val Gln Lys Glu Leu Arg Leu Leu Arg Gly Lys Thr Ile Glu Cys 
545                 550                 555                 560 


Ile Ser Leu Ile Gly Leu Ala Val Gly Lys Glu Lys Phe Met Gln Asp 
                565                 570                 575     


Ala Ser Asp Val Met Gln Leu Leu Leu Lys Thr Gln Thr Asp Phe Asn 
            580                 585                 590         


Asp Met Glu Asp Asp Asp Pro Gln Ile Ser Tyr Met Ile Ser Ala Trp 
        595                 600                 605             


Ala Arg Met Cys Lys Ile Leu Gly Lys Glu Phe Gln Gln Tyr Leu Pro 
    610                 615                 620                 


Val Val Met Gly Pro Leu Met Lys Thr Ala Ser Ile Lys Pro Glu Val 
625                 630                 635                 640 


Ala Leu Leu Asp Thr Gln Asp Met Glu Asn Met Ser Asp Asp Asp Gly 
                645                 650                 655     


Trp Glu Phe Val Asn Leu Gly Asp Gln Gln Ser Phe Gly Ile Lys Thr 
            660                 665                 670         


Ala Gly Leu Glu Glu Lys Ser Thr Ala Cys Gln Met Leu Val Cys Tyr 
        675                 680                 685             


Ala Lys Glu Leu Lys Glu Gly Phe Val Glu Tyr Thr Glu Gln Val Val 
    690                 695                 700                 


Lys Leu Met Val Pro Leu Leu Lys Phe Tyr Phe His Asp Gly Val Arg 
705                 710                 715                 720 


Val Ala Ala Ala Glu Ser Met Pro Leu Leu Leu Glu Cys Ala Arg Val 
                725                 730                 735     


Arg Gly Pro Glu Tyr Leu Thr Gln Met Trp His Phe Met Cys Asp Ala 
            740                 745                 750         


Leu Ile Lys Ala Ile Gly Thr Glu Pro Asp Ser Asp Val Leu Ser Glu 
        755                 760                 765             


Ile Met His Ser Phe Ala Lys Cys Ile Glu Val Met Gly Asp Gly Cys 
    770                 775                 780                 


Leu Asn Asn Glu His Phe Glu Glu Leu Gly Gly Ile Leu Lys Ala Lys 
785                 790                 795                 800 


Leu Glu Glu His Phe Lys Asn Gln Glu Leu Arg Gln Val Lys Arg Gln 
                805                 810                 815     


Asp Glu Asp Tyr Asp Glu Gln Val Glu Glu Ser Leu Gln Asp Glu Asp 
            820                 825                 830         


Asp Asn Asp Val Tyr Ile Leu Thr Lys Val Ser Asp Ile Leu His Ser 
        835                 840                 845             


Ile Phe Ser Ser Tyr Lys Glu Lys Val Leu Pro Trp Phe Glu Gln Leu 
    850                 855                 860                 


Leu Pro Leu Ile Val Asn Leu Ile Cys Pro His Arg Pro Trp Pro Asp 
865                 870                 875                 880 


Arg Gln Trp Gly Leu Cys Ile Phe Asp Asp Val Ile Glu His Cys Ser 
                885                 890                 895     


Pro Ala Ser Phe Lys Tyr Ala Glu Tyr Phe Leu Arg Pro Met Leu Gln 
            900                 905                 910         


Tyr Val Cys Asp Asn Ser Pro Glu Val Arg Gln Ala Ala Ala Tyr Gly 
        915                 920                 925             


Leu Gly Val Met Ala Gln Tyr Gly Gly Asp Asn Tyr Arg Pro Phe Cys 
    930                 935                 940                 


Thr Glu Ala Leu Pro Leu Leu Val Arg Val Ile Gln Ser Ala Asp Ser 
945                 950                 955                 960 


Lys Thr Lys Glu Asn Val Asn Ala Thr Glu Asn Cys Ile Ser Ala Val 
                965                 970                 975     


Gly Lys Ile Met Lys Phe Lys Pro Asp Cys Val Asn Val Glu Glu Val 
            980                 985                 990         


Leu Pro His Trp Leu Ser Trp Leu  Pro Leu His Glu Asp  Lys Glu Glu 
        995                 1000                 1005             


Ala Val  Gln Thr Phe Asn Tyr  Leu Cys Asp Leu Ile  Glu Ser Asn 
    1010                 1015                 1020             


His Pro  Ile Val Leu Gly Pro  Asn Asn Thr Asn Leu  Pro Lys Ile 
    1025                 1030                 1035             


Phe Ser  Ile Ile Ala Glu Gly  Glu Met His Glu Ala  Ile Lys His 
    1040                 1045                 1050             


Glu Asp  Pro Cys Ala Lys Arg  Leu Ala Asn Val Val  Arg Gln Val 
    1055                 1060                 1065             


Gln Thr  Ser Gly Gly Leu Trp  Thr Glu Cys Ile Ala  Gln Leu Ser 
    1070                 1075                 1080             


Pro Glu  Gln Gln Ala Ala Ile  Gln Glu Leu Leu Asn  Ser Ala 
    1085                 1090                 1095         


<210> 5939
<211> 904
<212> PRT
<213> Homo sapiens

<400> 5939
Met Phe Pro Ala Leu Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Glu Asp Phe Met Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys 
            20                  25                  30          


Ala Gln Arg Gly Ser Leu Pro Asn Ser Ala Thr His Gln His Val Arg 
        35                  40                  45              


Lys Asn Asn Pro Gln Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp 
    50                  55                  60                  


Asp Leu Ile Pro Asp Thr Leu Gln Lys Glu Lys Leu Leu Trp Pro Ile 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Val His Arg Gln Ile Glu Ala Ile Asn Arg Asp 
                85                  90                  95      


Phe His Ser Cys Leu Gly Trp Met Gln Trp Arg Gly Leu Ser Ser Leu 
            100                 105                 110         


Gln Pro Pro Pro Pro Arg Phe Lys Asp Ser Pro Ala Ser Ala Phe Arg 
        115                 120                 125             


Val Ala Gly Ile Thr Asp Ser His Met Leu Ser Leu Pro His Leu Arg 
    130                 135                 140                 


Ser Arg Gln Leu Leu Tyr Asp Glu Leu Asp Glu Val Asn Pro Arg Leu 
145                 150                 155                 160 


Arg Glu Pro Gln Glu Leu Phe Ser Ile Leu Ser Thr Lys Arg Pro Leu 
                165                 170                 175     


Gln Ala Pro Arg Trp Pro Ile Glu Cys Glu Val Ile Lys Glu Asn Ile 
            180                 185                 190         


His His Ile Glu Trp Ala Pro Pro Gln Pro Glu Tyr Phe Tyr Gln Pro 
        195                 200                 205             


Lys Gly Asn Glu Lys Val Pro Glu Ile Val Gly Glu Lys Lys Gly Thr 
    210                 215                 220                 


Val Val Tyr Gln Leu Asp Ser Val Pro Ile Glu Gly Ser Tyr Phe Thr 
225                 230                 235                 240 


Ser Ser Arg Val Gly Gly Lys Arg Gly Ile Val Lys Glu Leu Ala Val 
                245                 250                 255     


Thr Leu Gln Gly Pro Glu Asp Asn Thr Leu Leu Phe Glu Ser Arg Phe 
            260                 265                 270         


Glu Ser Gly Asn Leu Gln Lys Ala Val Arg Val Asp Thr Tyr Glu Tyr 
        275                 280                 285             


Glu Leu Thr Leu Arg Thr Asp Leu Tyr Thr Asn Lys His Thr Gln Trp 
    290                 295                 300                 


Phe Tyr Phe Arg Val Gln Asn Thr Arg Lys Asp Ala Thr Tyr Arg Phe 
305                 310                 315                 320 


Thr Ile Val Asn Leu Leu Lys Pro Lys Ser Leu Tyr Thr Val Gly Met 
                325                 330                 335     


Lys Pro Leu Leu Tyr Ser Gln Leu Asp Ala Asn Thr Arg Asn Ile Gly 
            340                 345                 350         


Trp Arg Arg Glu Gly Asn Glu Ile Lys Tyr Tyr Lys Asn Asn Thr Asp 
        355                 360                 365             


Asp Gly Gln Gln Pro Phe Tyr Cys Leu Thr Trp Thr Ile Gln Phe Pro 
    370                 375                 380                 


Tyr Asp Gln Asp Thr Cys Phe Phe Ala His Phe Tyr Pro Tyr Thr Tyr 
385                 390                 395                 400 


Thr Asp Leu Gln Cys Tyr Leu Leu Ser Val Ala Asn Asn Pro Ile Gln 
                405                 410                 415     


Ser Gln Phe Cys Lys Leu Gln Thr Leu Cys Arg Ser Leu Ala Gly Asn 
            420                 425                 430         


Thr Val Tyr Leu Leu Thr Ile Thr Asn Pro Ser Gln Thr Pro Gln Glu 
        435                 440                 445             


Ala Ala Ala Lys Lys Ala Val Val Leu Ser Ala Arg Val His Pro Gly 
    450                 455                 460                 


Glu Ser Asn Gly Ser Trp Val Met Lys Gly Phe Leu Asp Phe Ile Leu 
465                 470                 475                 480 


Ser Asn Ser Pro Asp Ala Gln Leu Leu Arg Asp Ile Phe Val Phe Lys 
                485                 490                 495     


Val Leu Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg 
            500                 505                 510         


Cys Ser Leu Ala Gly Arg Asp Leu Asn Arg His Tyr Lys Thr Ile Leu 
        515                 520                 525             


Lys Glu Ser Phe Pro Cys Ile Trp Tyr Thr Arg Asn Met Ile Lys Arg 
    530                 535                 540                 


Leu Leu Glu Glu Arg Glu Val Leu Leu Tyr Cys Asp Phe His Gly His 
545                 550                 555                 560 


Ser Arg Lys Asn Asn Ile Phe Leu Tyr Gly Cys Asn Asn Asn Asn Arg 
                565                 570                 575     


Lys Tyr Trp Leu His Glu Arg Val Phe Pro Leu Met Leu Cys Lys Asn 
            580                 585                 590         


Ala Pro Asp Lys Phe Ser Phe His Ser Cys Asn Phe Lys Val Gln Lys 
        595                 600                 605             


Cys Lys Glu Gly Thr Gly Arg Val Val Met Trp Arg Met Gly Ile Leu 
    610                 615                 620                 


Asn Ser Tyr Thr Met Glu Ser Thr Phe Gly Gly Ser Thr Leu Gly Asn 
625                 630                 635                 640 


Lys Arg Asp Thr His Phe Thr Ile Glu Asp Leu Lys Ser Leu Gly Tyr 
                645                 650                 655     


His Val Cys Asp Thr Leu Leu Asp Phe Cys Asp Pro Asp Gln Met Lys 
            660                 665                 670         


Phe Thr Gln Cys Leu Ala Glu Leu Lys Glu Leu Leu Arg Gln Glu Ile 
        675                 680                 685             


His Lys Lys Phe His Glu Leu Gly Gln Asp Val Asp Leu Glu Gly Ser 
    690                 695                 700                 


Trp Ser Asp Ile Ser Leu Ser Asp Ile Glu Ser Arg Asn Ser Thr Ser 
705                 710                 715                 720 


Gly Ser Asp Ser Ser Leu Ser Asp Gly Leu Pro Val His Leu Ala Asn 
                725                 730                 735     


Ile Ala Asp Glu Leu Thr Gln Lys Lys Lys Met Phe Lys Lys Lys Lys 
            740                 745                 750         


Lys Lys Ser Leu Gln Thr Arg Lys Gln Arg Asn Glu Gln Tyr Gln Lys 
        755                 760                 765             


Lys Asn Leu Met Gln Lys Leu Lys Leu Thr Glu Asp Thr Ser Glu Lys 
    770                 775                 780                 


Ala Gly Phe Ala Ser Thr Leu Gln Lys Gln Pro Thr Phe Phe Lys Asn 
785                 790                 795                 800 


Ser Glu Asn Ser Ser Phe Leu Pro Met Lys Asn Glu Asn Pro Arg Leu 
                805                 810                 815     


Asn Glu Thr Asn Leu Asn Arg Arg Asp Lys Asp Thr Pro Leu Asp Pro 
            820                 825                 830         


Ser Met Ala Thr Leu Ile Leu Pro Lys Asn Lys Gly Arg Met Gln Asn 
        835                 840                 845             


Lys Lys Pro Gly Phe Thr Val Ser Cys Ser Pro Lys Arg Thr Ile Asn 
    850                 855                 860                 


Ser Ser Gln Glu Pro Ala Pro Gly Met Lys Pro Asn Trp Pro Arg Ser 
865                 870                 875                 880 


Arg Tyr Pro Ala Thr Lys Arg Gly Cys Ala Ala Met Ala Ala Tyr Pro 
                885                 890                 895     


Ser Leu His Ile Tyr Thr Tyr Pro 
            900                 


<210> 5940
<211> 262
<212> PRT
<213> Homo sapiens

<400> 5940
Met Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly 
            20                  25                  30          


Gln Cys Pro Trp Arg Gly Ala Gly Ser Phe Leu Asp Pro Glu Ile Lys 
        35                  40                  45              


Ala Phe Leu Glu Glu Asn Thr Glu Val Thr Ser Ser Gly Ser Leu Thr 
    50                  55                  60                  


Pro Glu Ile Gln Leu Arg Leu Leu Thr Pro Arg Cys Lys Phe Trp Trp 
65                  70                  75                  80  


Glu Arg Ala Asp Leu Trp Pro His Ser Asp Pro Tyr Trp Ala Ile Tyr 
                85                  90                  95      


Trp Pro Gly Gly Gln Ala Leu Ser Arg Tyr Leu Leu Asp Asn Pro Asp 
            100                 105                 110         


Val Val Arg Gly Lys Ser Val Leu Asp Leu Gly Ser Gly Cys Gly Ala 
        115                 120                 125             


Thr Ala Ile Ala Ala Lys Met Ser Gly Ala Ser Arg Ile Leu Ala Asn 
    130                 135                 140                 


Asp Ile Asp Pro Ile Ala Gly Met Ala Ile Thr Leu Asn Cys Glu Leu 
145                 150                 155                 160 


Asn Arg Leu Asn Pro Phe Pro Ile Leu Ile Gln Asn Ile Leu Asn Leu 
                165                 170                 175     


Glu Gln Asp Lys Trp Asp Leu Val Val Leu Gly Asp Met Phe Tyr Asp 
            180                 185                 190         


Glu Asp Leu Ala Asp Ser Leu His Gln Trp Leu Lys Lys Cys Phe Trp 
        195                 200                 205             


Thr Tyr Arg Thr Arg Val Leu Ile Gly Asp Pro Gly Arg Pro Gln Phe 
    210                 215                 220                 


Ser Gly His Ser Ile Gln His His Leu His Lys Val Val Glu Tyr Ser 
225                 230                 235                 240 


Leu Leu Glu Ser Thr Arg Gln Glu Asn Ser Gly Leu Thr Thr Ser Thr 
                245                 250                 255     


Val Trp Gly Phe Gln Pro 
            260         


<210> 5941
<211> 872
<212> PRT
<213> Homo sapiens

<400> 5941
Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly 
1               5                   10                  15      


Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro 
            20                  25                  30          


Ala Phe Gly Gly Gly Val Cys Cys Phe Glu His Leu Pro Gly Gly Asp 
        35                  40                  45              


Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly 
    50                  55                  60                  


Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu 
65                  70                  75                  80  


Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser 
                85                  90                  95      


Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val Pro Thr 
        115                 120                 125             


Asn Ser Gly Gly Gly Gly Ala Thr Gly Gly Ser Pro Gly Glu Arg Lys 
    130                 135                 140                 


Arg Thr Arg Leu Gly Gly Pro Ala Ala Arg His Arg Tyr Glu Val Val 
145                 150                 155                 160 


Thr Glu Leu Gly Pro Glu Glu Val Arg Trp Phe Tyr Lys Glu Asp Lys 
                165                 170                 175     


Lys Thr Trp Lys Pro Phe Ile Gly Tyr Asp Ser Leu Arg Ile Glu Leu 
            180                 185                 190         


Ala Phe Arg Thr Leu Leu Gln Thr Thr Gly Ala Arg Pro Gln Gly Gly 
        195                 200                 205             


Asp Arg Asp Gly Asp His Val Cys Ser Pro Thr Gly Pro Ala Ser Ser 
    210                 215                 220                 


Ser Gly Glu Asp Asp Asp Glu Asp Arg Ala Cys Gly Phe Cys Gln Ser 
225                 230                 235                 240 


Thr Thr Gly His Glu Pro Glu Met Val Glu Leu Val Asn Ile Glu Pro 
                245                 250                 255     


Val Cys Val Arg Gly Gly Leu Tyr Glu Val Asp Val Thr Gln Gly Glu 
            260                 265                 270         


Cys Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val Met Arg 
        275                 280                 285             


Gly Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu Glu Glu 
    290                 295                 300                 


Ser Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly Gln Gln 
305                 310                 315                 320 


Met Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp Gly Lys 
                325                 330                 335     


Asp Ala Val His Ser Phe Lys Leu Ser Arg Asn His Val Asp Trp His 
            340                 345                 350         


Ser Val Asp Glu Val Tyr Leu Tyr Ser Asp Ala Thr Thr Ser Lys Ile 
        355                 360                 365             


Ala Arg Thr Val Thr Gln Lys Leu Gly Phe Ser Lys Ala Ser Ser Ser 
    370                 375                 380                 


Gly Thr Arg Leu His Arg Gly Tyr Val Glu Glu Ala Thr Leu Glu Asp 
385                 390                 395                 400 


Lys Pro Ser Gln Thr Thr His Ile Val Phe Val Val His Gly Ile Gly 
                405                 410                 415     


Gln Lys Met Asp Gln Gly Arg Ile Ile Lys Asn Thr Ala Met Met Arg 
            420                 425                 430         


Glu Ala Ala Arg Lys Ile Glu Glu Arg His Phe Ser Asn His Ala Thr 
        435                 440                 445             


His Val Glu Phe Leu Pro Val Glu Trp Arg Ser Lys Leu Thr Leu Asp 
    450                 455                 460                 


Gly Asp Thr Val Asp Ser Ile Thr Pro Asp Lys Val Arg Gly Leu Arg 
465                 470                 475                 480 


Asp Met Leu Asn Ser Ser Ala Met Asp Ile Met Tyr Tyr Thr Ser Pro 
                485                 490                 495     


Leu Tyr Arg Asp Glu Leu Val Lys Gly Leu Gln Gln Glu Leu Asn Arg 
            500                 505                 510         


Leu Tyr Ser Leu Phe Cys Ser Arg Asn Pro Asp Phe Glu Glu Lys Gly 
        515                 520                 525             


Gly Lys Val Ser Ile Val Ser His Ser Leu Gly Cys Val Ile Thr Tyr 
    530                 535                 540                 


Asp Ile Met Thr Gly Trp Asn Pro Val Arg Leu Tyr Glu Gln Leu Leu 
545                 550                 555                 560 


Gln Lys Glu Glu Glu Leu Pro Asp Glu Arg Trp Met Ser Tyr Glu Glu 
                565                 570                 575     


Arg His Leu Leu Asp Glu Leu Tyr Ile Thr Lys Arg Arg Leu Lys Glu 
            580                 585                 590         


Ile Glu Glu Arg Leu His Gly Leu Lys Ala Ser Ser Met Thr Gln Thr 
        595                 600                 605             


Pro Ala Leu Lys Phe Lys Val Glu Asn Phe Phe Cys Met Gly Ser Pro 
    610                 615                 620                 


Leu Ala Val Phe Leu Ala Leu Arg Gly Ile Arg Pro Gly Asn Thr Gly 
625                 630                 635                 640 


Ser Gln Asp His Ile Leu Pro Arg Glu Ile Cys Asn Arg Leu Leu Asn 
                645                 650                 655     


Ile Phe His Pro Thr Asp Pro Val Ala Tyr Arg Leu Glu Pro Leu Ile 
            660                 665                 670         


Leu Lys His Tyr Ser Asn Ile Ser Pro Val Gln Ile His Trp Tyr Asn 
        675                 680                 685             


Thr Ser Asn Pro Leu Pro Tyr Glu His Met Lys Pro Ser Phe Leu Asn 
    690                 695                 700                 


Pro Ala Lys Glu Pro Thr Ser Val Ser Glu Asn Glu Gly Ile Ser Thr 
705                 710                 715                 720 


Ile Pro Ser Pro Val Thr Ser Pro Val Leu Ser Arg Arg His Tyr Gly 
                725                 730                 735     


Glu Ser Ile Thr Asn Ile Gly Lys Ala Ser Ile Leu Gly Ala Ala Ser 
            740                 745                 750         


Ile Gly Lys Gly Leu Gly Gly Met Leu Phe Ser Arg Phe Gly Arg Ser 
        755                 760                 765             


Ser Thr Thr Gln Ser Ser Glu Thr Ser Lys Asp Ser Met Glu Asp Glu 
    770                 775                 780                 


Lys Lys Pro Val Ala Ser Pro Ser Ala Thr Thr Val Gly Thr Gln Thr 
785                 790                 795                 800 


Leu Pro His Ser Ser Ser Gly Phe Leu Asp Ser Ala Leu Glu Leu Asp 
                805                 810                 815     


His Arg Ile Asp Phe Glu Leu Arg Glu Gly Leu Val Glu Ser Arg Tyr 
            820                 825                 830         


Trp Ser Ala Val Thr Ser His Thr Ala Tyr Trp Ser Ser Leu Asp Val 
        835                 840                 845             


Ala Leu Phe Leu Leu Thr Phe Met Tyr Lys His Glu His Asp Asp Asp 
    850                 855                 860                 


Ala Lys Pro Asn Leu Asp Pro Ile 
865                 870         


<210> 5942
<211> 486
<212> PRT
<213> Homo sapiens

<400> 5942
Met Val Ser His Thr Phe His Met Arg Thr Glu Glu Ser Asp Ala Ser 
1               5                   10                  15      


Gln Glu Gly Asp Asp Leu Pro Lys Ser Ser Ala Asn Thr Ser His Pro 
            20                  25                  30          


Lys Gln Asp Asp Ser Pro Lys Ser Ser Glu Glu Thr Ile Gln Pro Lys 
        35                  40                  45              


Glu Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys 
    50                  55                  60                  


Glu Asp Leu Pro Lys Ser Ser Glu Lys Ala Ile Gln Pro Lys Glu Ser 
65                  70                  75                  80  


Asn Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn 
                85                  90                  95      


Ile Pro Lys Ala Ser Val Lys Pro Ser Gln Pro Lys Glu Gly Asp Ile 
            100                 105                 110         


Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys Glu Asp Leu Pro 
        115                 120                 125             


Lys Ser Ser Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys 
    130                 135                 140                 


Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Ala Lys Thr 
145                 150                 155                 160 


Ser Val Lys Pro Ser Gln Pro Lys Glu Ser Asp Ile Pro Lys Ser Pro 
                165                 170                 175     


Glu Glu Thr Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Ser Ala 
            180                 185                 190         


Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Pro Lys Ala Ser Val Lys 
        195                 200                 205             


Pro Ser Gln Pro Lys Glu Gly Asp Ile Ser Lys Ser Pro Glu Glu Ala 
    210                 215                 220                 


Ile Gln Pro Lys Glu Gly Asp Leu Pro Lys Ser Leu Glu Glu Ala Ile 
225                 230                 235                 240 


Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu Ala Ile Gln 
                245                 250                 255     


Pro Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala Ile Gln Pro 
            260                 265                 270         


Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys 
        275                 280                 285             


Lys Gly Asp Ile Pro Lys Ser Pro Glu Glu Ala Ile Gln Pro Lys Glu 
    290                 295                 300                 


Gly Asp Ile Pro Lys Ser Pro Lys Gln Ala Ile Gln Pro Lys Glu Gly 
305                 310                 315                 320 


Asp Ile Pro Lys Ser Leu Glu Glu Ala Ile Pro Pro Lys Glu Ile Asp 
                325                 330                 335     


Ile Pro Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu Asp Asp Ser 
            340                 345                 350         


Pro Lys Ser Leu Glu Glu Ala Thr Pro Ser Lys Glu Gly Asp Ile Leu 
        355                 360                 365             


Lys Pro Glu Glu Glu Thr Met Glu Phe Pro Glu Gly Asp Lys Val Lys 
    370                 375                 380                 


Val Ile Leu Ser Lys Glu Asp Phe Glu Ala Ser Leu Lys Glu Ala Gly 
385                 390                 395                 400 


Glu Arg Leu Val Ala Val Asp Phe Ser Ala Thr Trp Cys Gly Pro Cys 
                405                 410                 415     


Arg Thr Ile Arg Pro Phe Phe His Ala Leu Ser Val Lys His Glu Asp 
            420                 425                 430         


Val Val Phe Leu Glu Val Asp Ala Asp Asn Cys Glu Glu Val Val Arg 
        435                 440                 445             


Glu Cys Ala Ile Met Cys Val Pro Thr Phe Gln Phe Tyr Lys Lys Glu 
    450                 455                 460                 


Glu Lys Val Asp Glu Leu Cys Gly Ala Leu Lys Glu Lys Leu Glu Ala 
465                 470                 475                 480 


Val Ile Ala Glu Leu Lys 
                485     


<210> 5943
<211> 334
<212> PRT
<213> Homo sapiens

<400> 5943
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Thr Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Thr Lys Asp 
        35                  40                  45              


His His Tyr Phe Lys Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys 
    50                  55                  60                  


Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
65                  70                  75                  80  


Met Leu Gly Lys Val Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe 
                85                  90                  95      


Ala Leu Pro Val Glu Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala 
            100                 105                 110         


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
        115                 120                 125             


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
    130                 135                 140                 


Cys Trp Leu Ser Gly Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln 
145                 150                 155                 160 


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile 
                165                 170                 175     


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly 
            180                 185                 190         


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu 
        195                 200                 205             


Asn Lys Ile Glu Asp Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu 
    210                 215                 220                 


Glu Val Ser Tyr Phe Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu 
225                 230                 235                 240 


Leu Trp Asn Lys Tyr Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu 
                245                 250                 255     


Thr Asn Ala Asp Tyr Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys 
            260                 265                 270         


Leu Glu Gln Ser Glu Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly 
        275                 280                 285             


Leu Glu Thr His Asp Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr 
    290                 295                 300                 


Arg Asp Ser Cys Lys Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser 
305                 310                 315                 320 


Gln Val Ile Lys Asp Lys Leu Phe Asn Gln Ile Asn Ile Ser 
                325                 330                 


<210> 5944
<211> 449
<212> PRT
<213> Homo sapiens

<400> 5944
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
    130                 135                 140                 


Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
145                 150                 155                 160 


Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                165                 170                 175     


Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
            180                 185                 190         


Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
        195                 200                 205             


Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
    210                 215                 220                 


Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
225                 230                 235                 240 


Pro Lys Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro Pro 
                245                 250                 255     


Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro Arg 
            260                 265                 270         


Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp Asn 
        275                 280                 285             


Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly Asn 
    290                 295                 300                 


Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met Ser 
305                 310                 315                 320 


Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly Gly 
                325                 330                 335     


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
            340                 345                 350         


Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val Arg 
        355                 360                 365             


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu Thr 
    370                 375                 380                 


Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg Gly 
385                 390                 395                 400 


Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp Arg 
                405                 410                 415     


Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu Gly 
            420                 425                 430         


Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln Arg 
        435                 440                 445             


Arg 
    


<210> 5945
<211> 110
<212> PRT
<213> Homo sapiens

<400> 5945
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Ile Leu 
        35                  40                  45              


Leu Arg Leu Pro Thr Thr Arg Ile His Ser Val Asn Ser Cys Pro Ala 
    50                  55                  60                  


Leu Ser His Thr Gln Ala Ser Ala Phe Ser Gly Glu Thr Leu Ala Val 
65                  70                  75                  80  


Leu Thr Ala Gly Ile Ser Lys Arg Trp Pro Lys Tyr Arg Leu Pro Ile 
                85                  90                  95      


Asp Ile Ala Arg Pro Cys Ser Glu Thr Pro Phe Pro Arg Leu 
            100                 105                 110 


<210> 5946
<211> 273
<212> PRT
<213> Homo sapiens

<400> 5946
Met Gly Gln Lys Val Thr Gly Gly Ile Lys Thr Val Asp Met Arg Asp 
1               5                   10                  15      


Pro Thr Tyr Arg Pro Leu Lys Gln Glu Leu Gln Gly Leu Asp Tyr Cys 
            20                  25                  30          


Lys Pro Thr Arg Leu Asp Leu Leu Leu Asp Met Pro Pro Val Ser Tyr 
        35                  40                  45              


Asp Val Gln Leu Leu His Ser Trp Asn Asn Asn Asp Arg Ser Leu Asn 
    50                  55                  60                  


Val Phe Val Lys Glu Asp Asp Lys Leu Ile Phe His Arg His Pro Val 
65                  70                  75                  80  


Ala Gln Ser Thr Asp Ala Ile Arg Gly Lys Val Gly Tyr Thr Arg Gly 
                85                  90                  95      


Leu His Val Trp Gln Ile Thr Trp Ala Met Arg Gln Arg Gly Thr His 
            100                 105                 110         


Ala Val Val Gly Val Ala Thr Ala Asp Ala Pro Leu His Ser Val Gly 
        115                 120                 125             


Tyr Thr Thr Leu Val Gly Asn Asn His Glu Ser Trp Gly Trp Asp Leu 
    130                 135                 140                 


Gly Arg Asn Arg Leu Tyr His Asp Gly Lys Asn Gln Pro Ser Lys Thr 
145                 150                 155                 160 


Tyr Pro Ala Phe Leu Glu Pro Asp Glu Thr Phe Ile Val Pro Asp Ser 
                165                 170                 175     


Phe Leu Val Ala Leu Asp Met Asp Asp Gly Thr Leu Ser Phe Ile Val 
            180                 185                 190         


Asp Gly Gln Tyr Met Gly Val Ala Phe Arg Gly Leu Lys Gly Lys Lys 
        195                 200                 205             


Leu Tyr Pro Val Val Ser Ala Val Trp Gly His Cys Glu Ile Arg Met 
    210                 215                 220                 


Arg Tyr Leu Asn Gly Leu Asp Pro Glu Pro Leu Pro Leu Met Asp Leu 
225                 230                 235                 240 


Cys Arg Arg Ser Val Arg Leu Ala Leu Gly Arg Glu Arg Leu Gly Glu 
                245                 250                 255     


Ile His Thr Leu Pro Leu Pro Ala Ser Leu Lys Ala Tyr Leu Leu Tyr 
            260                 265                 270         


Gln 
    


<210> 5947
<211> 971
<212> PRT
<213> Homo sapiens

<400> 5947
Leu Ser Arg Arg Val Pro Cys Val Arg Arg Gly Cys Arg Pro Pro Leu 
1               5                   10                  15      


Pro Pro Leu Pro Gly Ser Gln Ser Arg Ala Trp Ser Arg Asp Arg Glu 
            20                  25                  30          


Ala Pro Leu Asp Pro Gly Arg Pro Ala Gln Ser Gly Arg Arg Pro Thr 
        35                  40                  45              


Ser Arg Ser Val Ser His Ala Cys Ser Trp Asn Gly Gly Ser Leu Asp 
    50                  55                  60                  


Pro Leu Glu Gly Thr Pro Ala Leu Leu Arg Ser Ala Glu Arg Leu Met 
65                  70                  75                  80  


Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser Trp 
                85                  90                  95      


Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr Thr 
            100                 105                 110         


Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp Pro 
        115                 120                 125             


Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg Ser 
    130                 135                 140                 


Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys Ala 
145                 150                 155                 160 


Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro His 
                165                 170                 175     


Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu Asn 
            180                 185                 190         


Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala Leu 
        195                 200                 205             


Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr Pro 
    210                 215                 220                 


His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys 
225                 230                 235                 240 


Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu Ser 
                245                 250                 255     


Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg Asp 
            260                 265                 270         


Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu Ile 
        275                 280                 285             


Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro Ala 
    290                 295                 300                 


Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val Ala 
305                 310                 315                 320 


Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln Gly 
                325                 330                 335     


Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr Phe 
            340                 345                 350         


Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys Pro 
        355                 360                 365             


Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile Leu 
    370                 375                 380                 


Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro Ser 
385                 390                 395                 400 


Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg Thr 
                405                 410                 415     


Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln Thr 
            420                 425                 430         


Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val Gln 
        435                 440                 445             


Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala Gly 
    450                 455                 460                 


Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg Pro 
465                 470                 475                 480 


Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile Pro 
                485                 490                 495     


Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val Pro 
            500                 505                 510         


Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val Trp 
        515                 520                 525             


Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly Glu 
    530                 535                 540                 


Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe Cys 
545                 550                 555                 560 


His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp Trp 
                565                 570                 575     


Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile Lys 
            580                 585                 590         


Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg His 
        595                 600                 605             


Gly Ser Lys Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe Gln 
    610                 615                 620                 


Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser Tyr 
625                 630                 635                 640 


Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser His 
                645                 650                 655     


Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr Ser 
            660                 665                 670         


Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly Pro 
        675                 680                 685             


Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met Met 
    690                 695                 700                 


Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe His 
705                 710                 715                 720 


Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys Pro 
                725                 730                 735     


His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val Tyr 
            740                 745                 750         


Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile Lys 
        755                 760                 765             


Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val Val 
    770                 775                 780                 


Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly Ala 
785                 790                 795                 800 


Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu Gly 
                805                 810                 815     


Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg Val 
            820                 825                 830         


Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly Leu 
        835                 840                 845             


Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro Val 
    850                 855                 860                 


Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Asp 
865                 870                 875                 880 


Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala Leu 
                885                 890                 895     


His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu His 
            900                 905                 910         


Gly Phe Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu Val 
        915                 920                 925             


Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr Pro 
    930                 935                 940                 


Asn Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu 
945                 950                 955                 960 


Val Thr Leu Leu His Phe Leu Gln Glu Tyr Leu 
                965                 970     


<210> 5948
<211> 863
<212> PRT
<213> Homo sapiens

<400> 5948
Met Gly Asn Arg Glu Met Glu Glu Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Leu Gly Gln Ser Cys Leu Leu Glu Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Thr Ser Lys Ala Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Asp Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Met Asn 
            100                 105                 110         


Lys Gly Ile Ser Ser Ile Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Glu Met Ile 
145                 150                 155                 160 


Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val Thr Pro 
                165                 170                 175     


Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu His Glu Val Glu Ala Tyr Lys Asn Phe Lys Pro Glu 
305                 310                 315                 320 


Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
            340                 345                 350         


Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Ile Val Lys Lys Gln 
                405                 410                 415     


Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu Val Ile 
            420                 425                 430         


Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Lys Leu Ala Asn 
        435                 440                 445             


Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Thr Thr Val 
            500                 505                 510         


Gly Asn Gln Val Ile Arg Lys Gly Trp Leu Thr Ile Ser Asn Ile Gly 
        515                 520                 525             


Ile Met Lys Gly Gly Ser Lys Gly Tyr Trp Phe Val Leu Thr Ala Glu 
    530                 535                 540                 


Ser Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met 
545                 550                 555                 560 


Leu Pro Leu Asp Asn Leu Lys Val Arg Asp Val Glu Lys Ser Phe Met 
                565                 570                 575     


Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu Gln Arg Asn Val 
            580                 585                 590         


Tyr Lys Asp Tyr Arg Phe Leu Glu Leu Ala Cys Asp Ser Gln Glu Asp 
        595                 600                 605             


Val Asp Ser Trp Lys Ala Ser Leu Leu Arg Ala Gly Val Tyr Pro Asp 
    610                 615                 620                 


Lys Ser Val Gly Asn Asn Lys Ala Glu Asn Asp Glu Asn Gly Gln Ala 
625                 630                 635                 640 


Glu Asn Phe Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile 
                645                 650                 655     


Arg Asn Leu Val Asp Ser Tyr Met Ser Ile Ile Asn Lys Cys Ile Arg 
            660                 665                 670         


Asp Leu Ile Pro Lys Thr Ile Met His Leu Met Ile Asn Asn Val Lys 
        675                 680                 685             


Asp Phe Ile Asn Ser Glu Leu Leu Ala Gln Leu Tyr Ser Ser Glu Asp 
    690                 695                 700                 


Gln Asn Thr Leu Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp 
705                 710                 715                 720 


Glu Met Leu Arg Met Tyr Gln Ala Leu Lys Glu Ala Leu Gly Ile Ile 
                725                 730                 735     


Gly Asp Ile Ser Thr Ala Thr Val Ser Thr Pro Ala Pro Pro Pro Val 
            740                 745                 750         


Asp Asp Ser Trp Ile Gln His Ser Arg Arg Ser Pro Pro Pro Ser Pro 
        755                 760                 765             


Thr Thr Gln Arg Arg Pro Thr Leu Ser Ala Pro Leu Ala Arg Pro Thr 
    770                 775                 780                 


Ser Gly Arg Gly Pro Ala Pro Ala Ile Pro Ser Pro Gly Pro His Ser 
785                 790                 795                 800 


Gly Ala Pro Pro Val Pro Phe Arg Pro Gly Pro Leu Pro Pro Phe Pro 
                805                 810                 815     


Ser Ser Ser Asp Ser Phe Gly Ala Pro Pro Gln Val Pro Ser Arg Pro 
            820                 825                 830         


Thr Arg Ala Pro Pro Ser Val Pro Ser Arg Arg Pro Pro Pro Ser Pro 
        835                 840                 845             


Thr Arg Pro Thr Ile Ile Arg Pro Leu Glu Ser Ser Leu Leu Asp 
    850                 855                 860             


<210> 5949
<211> 420
<212> PRT
<213> Homo sapiens

<400> 5949
Met Leu Lys Ala Val Ile Leu Ile Gly Gly Pro Gln Lys Gly Thr Arg 
1               5                   10                  15      


Phe Arg Pro Leu Ser Phe Glu Val Pro Lys Pro Leu Phe Pro Val Ala 
            20                  25                  30          


Gly Val Pro Met Ile Gln His His Ile Glu Ala Cys Ala Gln Val Pro 
        35                  40                  45              


Gly Met Gln Glu Ile Leu Leu Ile Gly Phe Tyr Gln Pro Asp Glu Pro 
    50                  55                  60                  


Leu Thr Gln Phe Leu Glu Ala Ala Gln Gln Glu Phe Asn Leu Pro Val 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Phe Ala Pro Leu Gly Thr Gly Gly Gly Leu Tyr 
                85                  90                  95      


His Phe Arg Asp Gln Ile Leu Ala Gly Ser Pro Glu Ala Phe Phe Val 
            100                 105                 110         


Leu Asn Ala Asp Val Cys Ser Asp Phe Pro Leu Ser Ala Met Leu Glu 
        115                 120                 125             


Ala His Arg Arg Gln Arg His Pro Phe Leu Leu Leu Gly Thr Thr Ala 
    130                 135                 140                 


Asn Arg Thr Gln Ser Leu Asn Tyr Gly Cys Ile Val Glu Asn Pro Gln 
145                 150                 155                 160 


Thr His Glu Val Leu His Tyr Val Glu Lys Pro Ser Thr Phe Ile Ser 
                165                 170                 175     


Asp Ile Ile Asn Cys Gly Ile Tyr Leu Phe Ser Pro Glu Ala Leu Lys 
            180                 185                 190         


Pro Leu Arg Asp Val Phe Gln Arg Asn Gln Gln Asp Gly Gln Leu Glu 
        195                 200                 205             


Asp Ser Pro Gly Leu Trp Pro Gly Ala Gly Thr Ile Arg Leu Glu Gln 
    210                 215                 220                 


Asp Val Phe Ser Ala Leu Ala Gly Gln Gly Gln Ile Tyr Val His Leu 
225                 230                 235                 240 


Thr Asp Gly Ile Trp Ser Gln Ile Lys Ser Ala Gly Ser Ala Leu Tyr 
                245                 250                 255     


Ala Ser Arg Leu Tyr Leu Ser Arg Tyr Gln Asp Thr His Pro Glu Arg 
            260                 265                 270         


Leu Ala Lys His Thr Pro Gly Gly Pro Trp Ile Arg Gly Asn Val Tyr 
        275                 280                 285             


Ile His Pro Thr Ala Lys Val Ala Pro Ser Ala Val Leu Gly Pro Asn 
    290                 295                 300                 


Val Ser Ile Gly Lys Gly Val Thr Val Gly Glu Gly Val Arg Leu Arg 
305                 310                 315                 320 


Glu Ser Ile Val Leu His Gly Ala Thr Leu Gln Glu His Thr Cys Val 
                325                 330                 335     


Leu His Ser Ile Val Gly Trp Gly Ser Thr Val Gly Arg Trp Ala Arg 
            340                 345                 350         


Val Glu Gly Thr Pro Ser Asp Pro Asn Pro Asn Asp Pro Arg Ala Arg 
        355                 360                 365             


Met Asp Ser Glu Ser Leu Phe Lys Asp Gly Lys Leu Leu Pro Ala Ile 
    370                 375                 380                 


Thr Ile Leu Gly Cys Arg Val Arg Ile Pro Ala Glu Val Leu Ile Leu 
385                 390                 395                 400 


Asn Ser Ile Val Leu Pro His Lys Glu Leu Ser Arg Ser Phe Thr Asn 
                405                 410                 415     


Gln Ile Ile Leu 
            420 


<210> 5950
<211> 826
<212> PRT
<213> Homo sapiens

<400> 5950
Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly 
145                 150                 155                 160 


Phe Ala Leu Ala Leu Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Pro 
                165                 170                 175     


Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg Ile His Ile Phe Ala Gln 
            180                 185                 190         


Gln Asn Asp Gln Phe Gln Lys Val Leu Ser Leu Cys Gly His Glu Asp 
        195                 200                 205             


Trp Ile Arg Gly Val Glu Trp Ala Ala Phe Gly Arg Asp Leu Phe Leu 
    210                 215                 220                 


Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg Ile Trp Lys Leu Tyr Ile 
225                 230                 235                 240 


Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp Asp Asn Ile Arg Leu Lys 
                245                 250                 255     


Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser Val Lys Ile Ala Phe Ala 
            260                 265                 270         


Val Thr Leu Glu Thr Val Leu Ala Gly His Glu Asn Trp Val Asn Ala 
        275                 280                 285             


Val His Trp Gln Pro Val Phe Tyr Lys Asp Gly Val Leu Gln Gln Pro 
    290                 295                 300                 


Val Arg Leu Leu Ser Ala Ser Met Asp Lys Thr Met Ile Leu Trp Ala 
305                 310                 315                 320 


Pro Asp Glu Glu Ser Gly Val Trp Leu Glu Gln Val Arg Val Gly Glu 
                325                 330                 335     


Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp Cys Gln Phe Asn Glu Asp 
            340                 345                 350         


Gly Ser Met Ile Ile Ala His Ala Phe His Gly Ala Leu His Leu Trp 
        355                 360                 365             


Lys Gln Asn Thr Val Asn Pro Arg Glu Trp Thr Pro Glu Ile Val Ile 
    370                 375                 380                 


Ser Gly His Phe Asp Gly Val Gln Asp Leu Val Trp Asp Pro Glu Gly 
385                 390                 395                 400 


Glu Phe Ile Ile Thr Val Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala 
                405                 410                 415     


Pro Trp Lys Arg Lys Asp Gln Ser Gln Val Thr Trp His Glu Ile Ala 
            420                 425                 430         


Arg Pro Gln Ile His Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn 
        435                 440                 445             


Arg Phe Gln Phe Val Ser Gly Ala Asp Glu Lys Val Leu Arg Val Phe 
    450                 455                 460                 


Ser Ala Pro Arg Asn Phe Val Glu Asn Phe Cys Ala Ile Thr Gly Gln 
465                 470                 475                 480 


Ser Leu Asn His Val Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly 
                485                 490                 495     


Ala Thr Val Pro Ala Leu Gly Leu Ser Asn Lys Ala Val Phe Gln Gly 
            500                 505                 510         


Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr 
        515                 520                 525             


Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln Pro Ser Ile Leu Thr Glu 
    530                 535                 540                 


Pro Pro Thr Glu Asp His Leu Leu Gln Asn Thr Leu Trp Pro Glu Val 
545                 550                 555                 560 


Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn 
                565                 570                 575     


Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu 
            580                 585                 590         


His Ala Ala Ile Ile Leu Trp Asn Thr Thr Ser Trp Lys Gln Val Gln 
        595                 600                 605             


Asn Leu Val Phe His Ser Leu Thr Val Thr Gln Met Ala Phe Ser Pro 
    610                 615                 620                 


Asn Glu Lys Phe Leu Leu Ala Val Ser Arg Asp Arg Thr Trp Ser Leu 
625                 630                 635                 640 


Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu Phe Glu Pro Val Phe Ser 
                645                 650                 655     


Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser Val His Ser Arg Ile Ile 
            660                 665                 670         


Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser 
        675                 680                 685             


Arg Asp Lys Lys Val Val Val Trp Gly Glu Cys Asp Ser Thr Asp Asp 
    690                 695                 700                 


Cys Ile Glu His Asn Ile Gly Pro Cys Ser Ser Val Leu Asp Val Gly 
705                 710                 715                 720 


Gly Ala Val Thr Ala Val Ser Val Cys Pro Val Leu His Pro Ser Gln 
                725                 730                 735     


Arg Tyr Val Val Ala Val Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr 
            740                 745                 750         


Thr Trp Lys Lys Thr Asp Gln Val Pro Glu Ile Asn Asp Trp Thr His 
        755                 760                 765             


Cys Val Glu Thr Ser Gln Ser Gln Ser His Thr Leu Ala Ile Arg Lys 
    770                 775                 780                 


Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu 
785                 790                 795                 800 


Gly Ala Glu Trp Leu His Phe Ala Ser Cys Gly Glu Asp His Thr Val 
                805                 810                 815     


Lys Ile His Arg Val Asn Lys Cys Ala Leu 
            820                 825     


<210> 5951
<211> 383
<212> PRT
<213> Homo sapiens

<400> 5951
Met Asp Arg Thr Cys Glu Glu Arg Pro Ala Glu Asp Gly Ser Asp Glu 
1               5                   10                  15      


Glu Asp Pro Asp Ser Met Glu Ala Pro Thr Arg Ile Arg Asp Thr Pro 
            20                  25                  30          


Glu Asp Ile Val Leu Glu Ala Pro Ala Ser Gly Leu Ala Phe His Pro 
        35                  40                  45              


Ala Arg Asp Leu Leu Ala Ala Gly Asp Val Asp Gly Asp Val Phe Val 
    50                  55                  60                  


Phe Ser Tyr Ser Cys Gln Glu Gly Glu Thr Lys Glu Leu Trp Ser Ser 
65                  70                  75                  80  


Gly His His Leu Lys Ala Cys Arg Ala Val Ala Phe Ser Glu Asp Gly 
                85                  90                  95      


Gln Lys Leu Ile Thr Val Ser Lys Asp Lys Ala Ile His Val Leu Asp 
            100                 105                 110         


Val Glu Gln Gly Gln Leu Glu Arg Arg Val Ser Lys Ala His Gly Ala 
        115                 120                 125             


Pro Ile Asn Ser Leu Leu Leu Val Asp Glu Asn Val Leu Ala Thr Gly 
    130                 135                 140                 


Asp Asp Thr Gly Gly Ile Cys Leu Trp Asp Gln Arg Lys Glu Gly Pro 
145                 150                 155                 160 


Leu Met Asp Met Arg Gln His Glu Glu Tyr Ile Ala Asp Met Ala Leu 
                165                 170                 175     


Asp Pro Ala Lys Lys Leu Leu Leu Thr Ala Ser Gly Asp Gly Cys Leu 
            180                 185                 190         


Gly Ile Phe Asn Ile Lys Arg Arg Arg Phe Glu Leu Leu Ser Glu Pro 
        195                 200                 205             


Gln Ser Gly Asp Leu Thr Ser Val Thr Leu Met Lys Trp Gly Lys Lys 
    210                 215                 220                 


Val Ala Cys Gly Ser Ser Glu Gly Thr Ile Tyr Leu Phe Asn Trp Asn 
225                 230                 235                 240 


Gly Phe Gly Ala Thr Ser Asp Arg Phe Ala Leu Arg Ala Glu Ser Ile 
                245                 250                 255     


Asp Cys Met Val Pro Val Thr Glu Ser Leu Leu Cys Thr Gly Ser Thr 
            260                 265                 270         


Asp Gly Val Ile Arg Ala Val Asn Ile Leu Pro Asn Arg Val Val Gly 
        275                 280                 285             


Ser Val Gly Gln His Thr Gly Glu Pro Val Glu Glu Leu Ala Leu Ser 
    290                 295                 300                 


His Cys Gly Arg Phe Leu Ala Ser Ser Gly His Asp Gln Arg Leu Lys 
305                 310                 315                 320 


Phe Trp Asp Met Ala Gln Leu Arg Ala Val Val Val Asp Asp Tyr Arg 
                325                 330                 335     


Arg Arg Lys Lys Lys Gly Gly Pro Leu Arg Ala Leu Ser Ser Lys Thr 
            340                 345                 350         


Trp Ser Thr Asp Asp Phe Phe Ala Gly Leu Arg Glu Glu Gly Glu Asp 
        355                 360                 365             


Ser Met Ala Gln Glu Glu Lys Glu Glu Thr Gly Asp Asp Ser Asp 
    370                 375                 380             


<210> 5952
<211> 332
<212> PRT
<213> Homo sapiens

<400> 5952
Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro 
        35                  40                  45              


Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys 
    50                  55                  60                  


Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp 
65                  70                  75                  80  


Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val 
                85                  90                  95      


Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly 
            100                 105                 110         


Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu 
        115                 120                 125             


Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr 
            260                 265                 270         


Gly Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro 
        275                 280                 285             


Gly Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly 
    290                 295                 300                 


Pro Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln 
305                 310                 315                 320 


Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
                325                 330         


<210> 5953
<211> 914
<212> PRT
<213> Homo sapiens

<400> 5953
Met Gly Asp Ser Arg Asp Leu Cys Pro His Leu Asp Ser Ile Gly Glu 
1               5                   10                  15      


Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Gly Thr Cys Gln Ser 
            20                  25                  30          


Cys Gly Val Thr Gly Pro Asn Leu Trp Ala Cys Leu Gln Val Ala Cys 
        35                  40                  45              


Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His 
    50                  55                  60                  


Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg 
65                  70                  75                  80  


Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu 
                85                  90                  95      


Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser 
            100                 105                 110         


Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp 
        115                 120                 125             


Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu 
    130                 135                 140                 


Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu 
145                 150                 155                 160 


Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe Phe Leu Glu Cys 
                165                 170                 175     


Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr 
            180                 185                 190         


Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val 
        195                 200                 205             


Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe 
    210                 215                 220                 


Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met 
225                 230                 235                 240 


Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala 
                245                 250                 255     


Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg 
            260                 265                 270         


Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser 
        275                 280                 285             


Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser 
    290                 295                 300                 


Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala 
305                 310                 315                 320 


Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln 
                325                 330                 335     


Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr 
            340                 345                 350         


Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser 
        355                 360                 365             


Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala 
    370                 375                 380                 


His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu 
385                 390                 395                 400 


Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg 
                405                 410                 415     


Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly 
            420                 425                 430         


Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile 
        435                 440                 445             


Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg 
    450                 455                 460                 


Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro 
465                 470                 475                 480 


Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val 
                485                 490                 495     


Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp 
            500                 505                 510         


Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr 
        515                 520                 525             


Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala 
    530                 535                 540                 


Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys 
545                 550                 555                 560 


Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu 
                565                 570                 575     


Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu 
            580                 585                 590         


Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu 
        595                 600                 605             


Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile 
    610                 615                 620                 


Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly 
625                 630                 635                 640 


Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp 
                645                 650                 655     


Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val 
            660                 665                 670         


Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu 
        675                 680                 685             


Ala Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu 
    690                 695                 700                 


Pro Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe 
705                 710                 715                 720 


Asn Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys 
                725                 730                 735     


Ser His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu 
            740                 745                 750         


Val Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe 
        755                 760                 765             


Gly Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln 
    770                 775                 780                 


Val Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr 
785                 790                 795                 800 


Phe Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val 
                805                 810                 815     


Ile Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val 
            820                 825                 830         


Lys Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile 
        835                 840                 845             


Ala Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp 
    850                 855                 860                 


Tyr Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr 
865                 870                 875                 880 


Gly Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu 
                885                 890                 895     


Gly Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg 
            900                 905                 910         


Ala Val 
        


<210> 5954
<211> 923
<212> PRT
<213> Homo sapiens

<400> 5954
Met Ala Ala Ser Thr Gly Tyr Val Arg Leu Trp Gly Ala Ala Arg Cys 
1               5                   10                  15      


Trp Val Leu Arg Arg Pro Met Leu Ala Ala Ala Gly Gly Arg Val Pro 
            20                  25                  30          


Thr Ala Ala Gly Ala Trp Leu Leu Arg Gly Gln Arg Thr Cys Asp Ala 
        35                  40                  45              


Ser Pro Pro Trp Ala Leu Trp Gly Arg Gly Pro Ala Ile Gly Gly Ser 
    50                  55                  60                  


Ala Gly Ala Gly Glu Gly Pro Val Ile Thr Ala Leu Thr Pro Met Thr 
65                  70                  75                  80  


Ile Pro Asp Val Phe Pro His Leu Pro Leu Ile Ala Ile Thr Arg Asn 
                85                  90                  95      


Pro Val Phe Pro Arg Phe Ile Lys Ile Ile Glu Val Lys Asn Lys Lys 
            100                 105                 110         


Leu Val Glu Leu Leu Arg Arg Lys Val Arg Leu Ala Gln Pro Tyr Val 
        115                 120                 125             


Gly Val Phe Leu Lys Arg Asp Asp Ser Asn Glu Ser Asp Val Val Glu 
    130                 135                 140                 


Ser Leu Asp Glu Ile Tyr His Thr Gly Thr Phe Ala Gln Ile His Glu 
145                 150                 155                 160 


Met Gln Asp Leu Gly Asp Lys Leu Arg Met Ile Val Met Gly His Arg 
                165                 170                 175     


Arg Val His Ile Ser Arg Gln Leu Glu Val Glu Pro Glu Glu Pro Glu 
            180                 185                 190         


Ala Glu Asn Lys His Lys Pro Arg Arg Lys Ser Lys Arg Gly Lys Lys 
        195                 200                 205             


Glu Ala Glu Asp Glu Leu Ser Ala Arg His Pro Ala Glu Leu Ala Met 
    210                 215                 220                 


Glu Pro Thr Pro Glu Leu Pro Ala Glu Val Leu Met Val Glu Val Glu 
225                 230                 235                 240 


Asn Val Val His Glu Asp Phe Gln Val Thr Glu Glu Val Lys Ala Leu 
                245                 250                 255     


Thr Ala Glu Ile Val Lys Thr Ile Arg Asp Ile Ile Ala Leu Asn Pro 
            260                 265                 270         


Leu Tyr Arg Glu Ser Val Leu Gln Met Met Gln Ala Gly Gln Arg Val 
        275                 280                 285             


Val Asp Asn Pro Ile Tyr Leu Ser Asp Met Gly Ala Ala Leu Thr Gly 
    290                 295                 300                 


Ala Glu Ser His Glu Leu Gln Asp Val Leu Glu Glu Thr Asn Ile Pro 
305                 310                 315                 320 


Lys Arg Leu Tyr Lys Ala Leu Ser Leu Leu Lys Lys Glu Phe Glu Leu 
                325                 330                 335     


Ser Lys Leu Gln Gln Arg Leu Gly Arg Glu Val Glu Glu Lys Ile Lys 
            340                 345                 350         


Gln Thr His Arg Lys Tyr Leu Leu Gln Glu Gln Leu Lys Ile Ile Lys 
        355                 360                 365             


Lys Glu Leu Gly Leu Glu Lys Asp Asp Lys Asp Ala Ile Glu Glu Lys 
    370                 375                 380                 


Phe Arg Glu Arg Leu Lys Glu Leu Val Val Pro Lys His Val Met Asp 
385                 390                 395                 400 


Val Val Asp Glu Glu Leu Ser Lys Leu Gly Leu Leu Asp Asn His Ser 
                405                 410                 415     


Ser Glu Phe Asn Val Thr Arg Asn Tyr Leu Asp Trp Leu Thr Ser Ile 
            420                 425                 430         


Pro Trp Gly Lys Tyr Ser Asn Glu Asn Leu Asp Leu Ala Arg Ala Gln 
        435                 440                 445             


Ala Val Leu Glu Glu Asp His Tyr Gly Met Glu Asp Val Lys Lys Arg 
    450                 455                 460                 


Ile Leu Glu Phe Ile Ala Val Ser Gln Leu Arg Gly Ser Thr Gln Gly 
465                 470                 475                 480 


Lys Ile Leu Cys Phe Tyr Gly Pro Pro Gly Val Gly Lys Thr Ser Ile 
                485                 490                 495     


Ala Arg Ser Ile Ala Arg Ala Leu Asn Arg Glu Tyr Phe Arg Phe Ser 
            500                 505                 510         


Val Gly Gly Met Thr Asp Val Ala Glu Ile Lys Gly His Arg Arg Thr 
        515                 520                 525             


Tyr Val Gly Ala Met Pro Gly Lys Ile Ile Gln Cys Leu Lys Lys Thr 
    530                 535                 540                 


Lys Thr Glu Asn Pro Leu Ile Leu Ile Asp Glu Val Asp Lys Ile Gly 
545                 550                 555                 560 


Arg Gly Tyr Gln Gly Asp Pro Ser Ser Ala Leu Leu Glu Leu Leu Asp 
                565                 570                 575     


Pro Glu Gln Asn Ala Asn Phe Leu Asp His Tyr Leu Asp Val Pro Val 
            580                 585                 590         


Asp Leu Ser Lys Val Leu Phe Ile Cys Thr Ala Asn Val Thr Asp Thr 
        595                 600                 605             


Ile Pro Glu Pro Leu Arg Asp Arg Met Glu Met Ile Asn Val Ser Gly 
    610                 615                 620                 


Tyr Val Ala Gln Glu Lys Leu Ala Ile Ala Glu Arg Tyr Leu Val Pro 
625                 630                 635                 640 


Gln Ala Arg Ala Leu Cys Gly Leu Asp Glu Ser Lys Ala Lys Leu Ser 
                645                 650                 655     


Ser Asp Val Leu Thr Leu Leu Ile Lys Gln Tyr Cys Arg Glu Ser Gly 
            660                 665                 670         


Val Arg Asn Leu Gln Lys Gln Val Glu Lys Val Leu Arg Lys Ser Ala 
        675                 680                 685             


Tyr Lys Ile Val Ser Gly Glu Ala Glu Ser Val Glu Val Thr Pro Glu 
    690                 695                 700                 


Asn Leu Gln Asp Phe Val Gly Lys Pro Val Phe Thr Val Glu Arg Met 
705                 710                 715                 720 


Tyr Asp Val Thr Pro Pro Gly Val Val Met Gly Leu Ala Trp Thr Ala 
                725                 730                 735     


Met Gly Gly Ser Thr Leu Phe Val Glu Thr Ser Leu Arg Arg Pro Gln 
            740                 745                 750         


Asp Lys Asp Ala Lys Gly Asp Lys Asp Gly Ser Leu Glu Val Thr Gly 
        755                 760                 765             


Gln Leu Gly Glu Val Met Lys Glu Ser Ala Arg Ile Ala Tyr Thr Phe 
    770                 775                 780                 


Ala Arg Ala Phe Leu Met Gln His Ala Pro Ala Asn Asp Tyr Leu Val 
785                 790                 795                 800 


Thr Ser His Ile His Leu His Val Pro Glu Gly Ala Thr Pro Lys Asp 
                805                 810                 815     


Gly Pro Ser Ala Gly Cys Thr Ile Val Thr Ala Leu Leu Ser Leu Ala 
            820                 825                 830         


Met Gly Arg Pro Val Arg Gln Asn Leu Ala Met Thr Gly Glu Val Ser 
        835                 840                 845             


Leu Thr Gly Lys Ile Leu Pro Val Gly Gly Ile Lys Glu Lys Thr Ile 
    850                 855                 860                 


Ala Ala Lys Arg Ala Gly Val Thr Cys Ile Val Leu Pro Ala Glu Asn 
865                 870                 875                 880 


Lys Lys Asp Phe Tyr Asp Leu Ala Ala Phe Ile Thr Glu Gly Leu Glu 
                885                 890                 895     


Val His Phe Val Glu His Tyr Arg Glu Ile Phe Asp Ile Ala Phe Pro 
            900                 905                 910         


Asp Glu Gln Ala Glu Ala Leu Ala Val Glu Arg 
        915                 920             


<210> 5955
<211> 226
<212> PRT
<213> Homo sapiens

<400> 5955
Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala Ala Glu Lys 
    130                 135                 140                 


Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu Lys Ile Ala 
145                 150                 155                 160 


Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu Ala Ala Cys 
                165                 170                 175     


Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala His Val Asp Gly 
            180                 185                 190         


Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu Leu Ala His 
        195                 200                 205             


Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro Ala Val Asn Ala 
    210                 215                 220                 


Arg Leu 
225     


<210> 5956
<211> 684
<212> PRT
<213> Homo sapiens

<400> 5956
Met Glu Ala Asn His Ser Glu Gln Leu Ser Ala Glu Arg Gln Ser Thr 
1               5                   10                  15      


Pro Pro Gly Asp Ser Ser Ser Leu Pro Ser His Asn Gly Leu Glu Lys 
            20                  25                  30          


Glu Asp Gly Gln Asp Ser Pro Thr Pro Val Gln Pro Pro Glu Lys Glu 
        35                  40                  45              


Ala Ser Val His Pro Asp Ile Ser Glu Glu Leu Asn Arg Gln Leu Glu 
    50                  55                  60                  


Asp Ile Ile Asn Thr Tyr Gly Ser Ala Ala Ser Thr Ala Gly Lys Glu 
65                  70                  75                  80  


Gly Ser Ala Arg Ala Ser Glu Gln Pro Glu Asn Ala Glu Ser Pro Asp 
                85                  90                  95      


Asn Glu Asp Gly Asp Cys Glu Glu Thr Thr Glu Glu Ala Gly Arg Glu 
            100                 105                 110         


Pro Val Ala Ser Gly Glu Pro Pro Thr Val Lys Glu Pro Val Ser Asn 
        115                 120                 125             


Lys Glu Gln Lys Leu Glu Lys Lys Ile Leu Lys Gly Leu Gly Lys Glu 
    130                 135                 140                 


Ala Asn Leu Leu Met Gln Asn Leu Asn Lys Leu Gln Thr Pro Glu Glu 
145                 150                 155                 160 


Lys Phe Asp Phe Leu Phe Lys Lys Tyr Ala Glu Leu Leu Asp Glu His 
                165                 170                 175     


Arg Thr Glu Gln Lys Lys Leu Lys Leu Leu Gln Lys Lys Gln Val Gln 
            180                 185                 190         


Ile Gln Lys Glu Lys Asp Gln Leu Gln Gly Glu His Ser Arg Ala Ile 
        195                 200                 205             


Leu Ala Arg Ser Lys Leu Glu Ser Leu Cys Arg Glu Leu Gln Arg His 
    210                 215                 220                 


Asn Lys Thr Leu Lys Glu Glu Ala Leu Gln Arg Ala Arg Glu Glu Glu 
225                 230                 235                 240 


Glu Lys Arg Lys Glu Ile Thr Ser His Phe Gln Ser Thr Leu Thr Asp 
                245                 250                 255     


Ile Gln Gly Gln Ile Glu Gln Gln Ser Glu Arg Asn Met Lys Leu Cys 
            260                 265                 270         


Gln Glu Asn Thr Glu Leu Ala Glu Lys Leu Lys Ser Ile Ile Asp Gln 
        275                 280                 285             


Tyr Glu Leu Arg Glu Glu His Leu Asp Lys Ile Phe Lys His Arg Glu 
    290                 295                 300                 


Leu Gln Gln Lys Leu Val Asp Ala Lys Leu Glu Gln Ala Gln Glu Met 
305                 310                 315                 320 


Met Lys Glu Ala Glu Glu Arg His Lys Arg Glu Lys Glu Tyr Leu Leu 
                325                 330                 335     


Asn Gln Ala Ala Glu Trp Lys Leu Gln Ala Lys Val Leu Lys Glu Gln 
            340                 345                 350         


Glu Thr Val Leu Gln Ala Gln Leu Thr Leu Tyr Ser Gly Arg Phe Glu 
        355                 360                 365             


Glu Phe Gln Ser Thr Leu Thr Lys Ser Asn Glu Val Phe Ala Thr Phe 
    370                 375                 380                 


Lys Gln Glu Met Asp Lys Thr Thr Lys Lys Met Lys Lys Leu Glu Lys 
385                 390                 395                 400 


Asp Thr Ala Thr Trp Lys Ala Arg Phe Glu Asn Cys Asn Lys Ala Leu 
                405                 410                 415     


Leu Asp Met Ile Glu Glu Lys Ala Leu Arg Ala Lys Glu Tyr Glu Cys 
            420                 425                 430         


Phe Val Met Lys Ile Gly Arg Leu Glu Asn Leu Cys Arg Ala Leu Gln 
        435                 440                 445             


Glu Glu Arg Asn Glu Leu His Lys Lys Ile Arg Asp Ala Glu Ile Ser 
    450                 455                 460                 


Glu Lys Asp Asp Gln Ser Gln His Asn Ser Asp Glu Glu Pro Glu Ser 
465                 470                 475                 480 


Asn Val Ser Val Asp Gln Glu Ile Asp Ala Glu Glu Val Asn Ser Val 
                485                 490                 495     


Gln Thr Ala Val Lys Asn Leu Ala Thr Ala Phe Met Ile Ile His His 
            500                 505                 510         


Pro Glu Ser Thr Pro His Gln Ser Lys Glu Thr Gln Pro Glu Ile Gly 
        515                 520                 525             


Ser Ser Gln Glu Ser Ala Asp Ala Ala Leu Lys Glu Pro Glu Gln Pro 
    530                 535                 540                 


Pro Leu Ile Pro Ser Arg Asp Ser Glu Ser Pro Leu Pro Pro Leu Thr 
545                 550                 555                 560 


Pro Gln Ala Glu Ala Glu Gly Gly Ser Asp Ala Glu Pro Pro Ser Lys 
                565                 570                 575     


Ala Ser Asn Ser Pro Ala Gly Leu Gly Ala Glu Thr Gln Cys Glu Gly 
            580                 585                 590         


Leu Pro Val Gly Ala Gln Ala Asp Gln Ala Ser Trp Lys Pro Glu Ala 
        595                 600                 605             


Glu Ala Ser Gly Gln Ala Pro Gln Ala Pro Thr Glu Ala Ser Leu Gln 
    610                 615                 620                 


Lys Met Glu Ala Asp Val Pro Ala Pro Ala Cys Ala Ala Glu Glu His 
625                 630                 635                 640 


Val Ala Ala Met Val Pro Ala Cys Glu Pro Ser Arg Gln Pro Pro Arg 
                645                 650                 655     


Ala Ala Ala Glu Glu Leu Pro Val Gly Ala Ser Ala Gly Pro Gln Pro 
            660                 665                 670         


Arg Asn Val Ala Asp Thr Asn Leu Glu Gly Val Asp 
        675                 680                 


<210> 5957
<211> 486
<212> PRT
<213> Homo sapiens

<400> 5957
Met Asn Gly Thr Leu Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu 
            20                  25                  30          


Arg Glu Leu Phe Glu Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Met Lys Val Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Asn Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Ile Ser Lys Lys Cys Thr Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Ser Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Thr Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Thr Ala Ile Lys Ala Met His Gln Ala Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Met Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Lys Arg Met Ala Gln Gln Leu Gln Gln Gln Met Gln Gln Ile 
        195                 200                 205             


Ser Ala Ala Ser Val Trp Gly Asn Leu Ala Gly Leu Asn Thr Leu Gly 
    210                 215                 220                 


Pro Gln Tyr Leu Ala Leu Tyr Leu Gln Leu Leu Gln Gln Thr Ala Ser 
225                 230                 235                 240 


Ser Gly Asn Leu Asn Thr Leu Ser Ser Leu His Pro Met Gly Gly Leu 
                245                 250                 255     


Asn Ala Met Gln Leu Gln Asn Leu Ala Ala Leu Ala Ala Ala Ala Ser 
            260                 265                 270         


Ala Ala Gln Asn Thr Pro Ser Gly Thr Asn Ala Leu Thr Thr Ser Ser 
        275                 280                 285             


Ser Pro Leu Ser Val Leu Thr Ser Ser Gly Ser Ser Pro Ser Ser Ser 
    290                 295                 300                 


Ser Ser Asn Ser Val Asn Pro Ile Ala Ser Leu Gly Ala Leu Gln Thr 
305                 310                 315                 320 


Leu Ala Gly Ala Thr Ala Gly Leu Asn Val Gly Ser Leu Ala Gly Met 
                325                 330                 335     


Ala Ala Leu Asn Gly Gly Leu Gly Ser Ser Gly Leu Ser Asn Gly Thr 
            340                 345                 350         


Gly Ser Thr Met Glu Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln 
        355                 360                 365             


Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr Asn Gln Asn Leu Leu Thr 
    370                 375                 380                 


Gln Gln Ser Ile Gly Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly 
385                 390                 395                 400 


Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln Asp 
                405                 410                 415     


Leu Leu Gln Met Phe Met Pro Phe Gly Asn Val Val Ser Ala Lys Val 
            420                 425                 430         


Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val Ser 
        435                 440                 445             


Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln Ser Met Asn Gly 
    450                 455                 460                 


Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser Lys 
465                 470                 475                 480 


Asn Asp Ser Lys Pro Tyr 
                485     


<210> 5958
<211> 2603
<212> PRT
<213> Homo sapiens

<400> 5958
Met Glu Lys Ala Thr Val Pro Val Ala Ala Ala Thr Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Thr Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Thr Ala Ser Lys Leu Leu Leu Ser Gly Thr Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Thr Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr 
                325                 330                 335     


Ala Leu Thr Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Thr Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp 
            420                 425                 430         


Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Thr Thr Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Thr Thr Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser 
    770                 775                 780                 


Ser Ser His Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Thr 
785                 790                 795                 800 


Asn Gln Ser Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Thr 
                805                 810                 815     


Glu Leu Glu Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu 
            820                 825                 830         


Gln Ser Leu Glu Leu Ala His Ala Asp Gln Leu Thr Lys Glu Lys Ile 
        835                 840                 845             


Glu Glu Leu Asn Lys Thr Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys 
    850                 855                 860                 


Ile Leu Glu Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Thr 
865                 870                 875                 880 


Gln Gln Gln Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile 
                885                 890                 895     


Gln Leu Gln Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu 
            900                 905                 910         


Thr Pro Val Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg 
        915                 920                 925             


Leu Gln Gln Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Thr 
    930                 935                 940                 


Ala Ala Gln Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln 
945                 950                 955                 960 


Ala Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn 
                965                 970                 975     


Leu Thr Glu Leu Gln Gly Val Ile Val Gly Gln Pro Val Leu Gly Gln 
            980                 985                 990         


Ala Gln Leu Ala Gly Leu Gly Gln  Gly Ile Leu Thr Glu  Thr Gln Gln 
        995                 1000                 1005             


Gly Leu  Met Val Ala Ser Pro  Ala Gln Thr Leu Asn  Asp Thr Leu 
    1010                 1015                 1020             


Asp Asp  Ile Met Ala Ala Val  Ser Gly Arg Ala Ser  Ala Met Ser 
    1025                 1030                 1035             


Asn Thr  Pro Thr His Ser Ile  Ala Ala Ser Ile Ser  Gln Pro Gln 
    1040                 1045                 1050             


Thr Pro  Thr Pro Ser Pro Ile  Ile Ser Pro Ser Ala  Met Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Pro Ala Ile Asp Ile  Asp Ala Gln Thr Glu  Ser Asn His 
    1070                 1075                 1080             


Asp Thr  Ala Leu Thr Leu Ala  Cys Ala Gly Gly His  Glu Glu Leu 
    1085                 1090                 1095             


Val Gln  Thr Leu Leu Glu Arg  Gly Ala Ser Ile Glu  His Arg Asp 
    1100                 1105                 1110             


Lys Lys  Gly Phe Thr Pro Leu  Ile Leu Ala Ala Thr  Ala Gly His 
    1115                 1120                 1125             


Val Gly  Val Val Glu Ile Leu  Leu Asp Asn Gly Ala  Asp Ile Glu 
    1130                 1135                 1140             


Ala Gln  Ser Glu Arg Thr Lys  Asp Thr Pro Leu Ser  Leu Ala Cys 
    1145                 1150                 1155             


Ser Gly  Gly Arg Gln Glu Val  Val Glu Leu Leu Leu  Ala Arg Gly 
    1160                 1165                 1170             


Ala Asn  Lys Glu His Arg Asn  Val Ser Asp Tyr Thr  Pro Leu Ser 
    1175                 1180                 1185             


Leu Ala  Ala Ser Gly Gly Tyr  Val Asn Ile Ile Lys  Ile Leu Leu 
    1190                 1195                 1200             


Asn Ala  Gly Ala Glu Ile Asn  Ser Arg Thr Gly Ser  Lys Leu Gly 
    1205                 1210                 1215             


Ile Ser  Pro Leu Met Leu Ala  Ala Met Asn Gly His  Thr Ala Ala 
    1220                 1225                 1230             


Val Lys  Leu Leu Leu Asp Met  Gly Ser Asp Ile Asn  Ala Gln Ile 
    1235                 1240                 1245             


Glu Thr  Asn Arg Asn Thr Ala  Leu Thr Leu Ala Cys  Phe Gln Gly 
    1250                 1255                 1260             


Arg Thr  Glu Val Val Ser Leu  Leu Leu Asp Arg Lys  Ala Asn Val 
    1265                 1270                 1275             


Glu His  Arg Ala Lys Thr Gly  Leu Thr Pro Leu Met  Glu Ala Ala 
    1280                 1285                 1290             


Ser Gly  Gly Tyr Ala Glu Val  Gly Arg Val Leu Leu  Asp Lys Gly 
    1295                 1300                 1305             


Ala Asp  Val Asn Ala Pro Pro  Val Pro Ser Ser Arg  Asp Thr Ala 
    1310                 1315                 1320             


Leu Thr  Ile Ala Ala Asp Lys  Gly His Tyr Lys Phe  Cys Glu Leu 
    1325                 1330                 1335             


Leu Ile  Gly Arg Gly Ala His  Ile Asp Val Arg Asn  Lys Lys Gly 
    1340                 1345                 1350             


Asn Thr  Pro Leu Trp Leu Ala  Ala Asn Gly Gly His  Leu Asp Val 
    1355                 1360                 1365             


Val Gln  Leu Leu Val Gln Ala  Gly Ala Asp Val Asp  Ala Ala Asp 
    1370                 1375                 1380             


Asn Arg  Lys Ile Thr Pro Leu  Met Ala Ala Phe Arg  Lys Gly His 
    1385                 1390                 1395             


Val Lys  Val Val Arg Tyr Leu  Val Lys Glu Val Asn  Gln Phe Pro 
    1400                 1405                 1410             


Ser Asp  Ser Glu Cys Met Arg  Tyr Ile Ala Thr Ile  Thr Asp Lys 
    1415                 1420                 1425             


Glu Met  Leu Lys Lys Cys His  Leu Cys Met Glu Ser  Ile Val Gln 
    1430                 1435                 1440             


Ala Lys  Asp Arg Gln Ala Ala  Glu Ala Asn Lys Asn  Ala Ser Ile 
    1445                 1450                 1455             


Leu Leu  Glu Glu Leu Asp Leu  Glu Lys Leu Arg Glu  Glu Ser Arg 
    1460                 1465                 1470             


Arg Leu  Ala Leu Ala Ala Lys  Arg Glu Lys Arg Lys  Glu Lys Arg 
    1475                 1480                 1485             


Arg Lys  Lys Lys Glu Glu Gln  Arg Arg Lys Leu Glu  Glu Ile Glu 
    1490                 1495                 1500             


Ala Lys  Asn Lys Glu Asn Phe  Glu Leu Gln Ala Ala  Gln Glu Lys 
    1505                 1510                 1515             


Glu Lys  Leu Lys Val Glu Asp  Glu Pro Glu Val Leu  Thr Glu Pro 
    1520                 1525                 1530             


Pro Ser  Ala Thr Thr Thr Thr  Thr Ile Gly Ile Ser  Ala Thr Trp 
    1535                 1540                 1545             


Thr Thr  Leu Ala Gly Ser His  Gly Lys Arg Asn Asn  Thr Ile Thr 
    1550                 1555                 1560             


Thr Thr  Ser Ser Lys Arg Lys  Asn Arg Lys Asn Lys  Ile Thr Pro 
    1565                 1570                 1575             


Glu Asn  Val Gln Ile Ile Phe  Asp Asp Pro Leu Pro  Ile Ser Tyr 
    1580                 1585                 1590             


Ser Gln  Pro Glu Lys Val Asn  Gly Glu Ser Lys Ser  Ser Ser Thr 
    1595                 1600                 1605             


Ser Glu  Ser Gly Asp Ser Asp  Asn Met Arg Ile Ser  Ser Cys Ser 
    1610                 1615                 1620             


Asp Glu  Ser Ser Asn Ser Asn  Ser Ser Arg Lys Ser  Asp Asn His 
    1625                 1630                 1635             


Ser Pro  Ala Val Val Thr Thr  Thr Val Ser Ser Lys  Lys Gln Pro 
    1640                 1645                 1650             


Ser Val  Leu Val Thr Phe Pro  Lys Glu Glu Arg Lys  Ser Val Ser 
    1655                 1660                 1665             


Gly Lys  Ala Ser Ile Lys Leu  Ser Glu Thr Ile Ser  Glu Gly Thr 
    1670                 1675                 1680             


Ser Asn  Ser Leu Ser Thr Cys  Thr Lys Ser Gly Pro  Ser Pro Leu 
    1685                 1690                 1695             


Ser Ser  Pro Asn Gly Lys Leu  Thr Val Ala Ser Pro  Lys Arg Gly 
    1700                 1705                 1710             


Gln Lys  Arg Glu Glu Gly Trp  Lys Glu Val Val Arg  Arg Ser Lys 
    1715                 1720                 1725             


Lys Val  Ser Val Pro Ser Thr  Val Ile Ser Arg Val  Ile Gly Arg 
    1730                 1735                 1740             


Gly Gly  Cys Asn Ile Asn Ala  Ile Arg Glu Phe Thr  Gly Ala His 
    1745                 1750                 1755             


Ile Asp  Ile Asp Lys Gln Lys  Asp Lys Thr Gly Asp  Arg Ile Ile 
    1760                 1765                 1770             


Thr Ile  Arg Gly Gly Thr Glu  Ser Thr Arg Gln Ala  Thr Gln Leu 
    1775                 1780                 1785             


Ile Asn  Ala Leu Ile Lys Asp  Pro Asp Lys Glu Ile  Asp Glu Leu 
    1790                 1795                 1800             


Ile Pro  Lys Asn Arg Leu Lys  Ser Ser Ser Ala Asn  Ser Lys Ile 
    1805                 1810                 1815             


Gly Ser  Ser Ala Pro Thr Thr  Thr Ala Ala Asn Thr  Ser Leu Met 
    1820                 1825                 1830             


Gly Ile  Lys Met Thr Thr Val  Ala Leu Ser Ser Thr  Ser Gln Thr 
    1835                 1840                 1845             


Ala Thr  Ala Leu Thr Val Pro  Ala Ile Ser Ser Ala  Ser Thr His 
    1850                 1855                 1860             


Lys Thr  Ile Lys Asn Pro Val  Asn Asn Val Arg Pro  Gly Phe Pro 
    1865                 1870                 1875             


Val Ser  Leu Pro Leu Ala Tyr  Pro Pro Pro Gln Phe  Ala His Ala 
    1880                 1885                 1890             


Leu Leu  Ala Ala Gln Thr Phe  Gln Gln Ile Arg Pro  Pro Arg Leu 
    1895                 1900                 1905             


Pro Met  Thr His Phe Gly Gly  Thr Phe Pro Pro Ala  Gln Ser Thr 
    1910                 1915                 1920             


Trp Gly  Pro Phe Pro Val Arg  Pro Leu Ser Pro Ala  Arg Ala Thr 
    1925                 1930                 1935             


Asn Ser  Pro Lys Pro His Met  Val Pro Arg His Ser  Asn Gln Asn 
    1940                 1945                 1950             


Ser Ser  Gly Ser Gln Val Asn  Ser Ala Gly Ser Leu  Thr Ser Ser 
    1955                 1960                 1965             


Pro Thr  Thr Thr Thr Ser Ser  Ser Ala Ser Thr Val  Pro Gly Thr 
    1970                 1975                 1980             


Ser Thr  Asn Gly Ser Pro Ser  Ser Pro Ser Val Arg  Arg Gln Leu 
    1985                 1990                 1995             


Phe Val  Thr Val Val Lys Thr  Ser Asn Ala Thr Thr  Thr Thr Val 
    2000                 2005                 2010             


Thr Thr  Thr Ala Ser Asn Asn  Asn Thr Ala Pro Thr  Asn Ala Thr 
    2015                 2020                 2025             


Tyr Pro  Met Pro Thr Ala Lys  Glu His Tyr Pro Val  Ser Ser Pro 
    2030                 2035                 2040             


Ser Ser  Pro Ser Pro Pro Ala  Gln Pro Gly Gly Val  Ser Arg Asn 
    2045                 2050                 2055             


Ser Pro  Leu Asp Cys Gly Ser  Ala Ser Pro Asn Lys  Val Ala Ser 
    2060                 2065                 2070             


Ser Ser  Glu Gln Glu Ala Gly  Ser Pro Pro Val Val  Glu Thr Thr 
    2075                 2080                 2085             


Asn Thr  Arg Pro Pro Asn Ser  Ser Ser Ser Ser Gly  Ser Ser Ser 
    2090                 2095                 2100             


Ala His  Ser Asn Gln Gln Gln  Pro Pro Gly Ser Val  Ser Gln Glu 
    2105                 2110                 2115             


Pro Arg  Pro Pro Leu Gln Gln  Ser Gln Val Pro Pro  Pro Glu Val 
    2120                 2125                 2130             


Arg Met  Thr Val Pro Pro Leu  Ala Thr Ser Ser Ala  Pro Val Ala 
    2135                 2140                 2145             


Val Pro  Ser Thr Ala Pro Val  Thr Tyr Pro Met Pro  Gln Thr Pro 
    2150                 2155                 2160             


Met Gly  Cys Pro Gln Pro Thr  Pro Lys Met Glu Thr  Pro Ala Ile 
    2165                 2170                 2175             


Arg Pro  Pro Pro His Gly Thr  Thr Ala Pro His Lys  Asn Ser Ala 
    2180                 2185                 2190             


Ser Val  Gln Asn Ser Ser Val  Ala Val Leu Ser Val  Asn His Ile 
    2195                 2200                 2205             


Lys Arg  Pro His Ser Val Pro  Ser Ser Val Gln Leu  Pro Ser Thr 
    2210                 2215                 2220             


Leu Ser  Thr Gln Ser Ala Cys  Gln Asn Ser Val His  Pro Ala Asn 
    2225                 2230                 2235             


Lys Pro  Ile Ala Pro Asn Phe  Ser Ala Pro Leu Pro  Phe Gly Pro 
    2240                 2245                 2250             


Phe Ser  Thr Leu Phe Glu Asn  Ser Pro Thr Ser Ala  His Ala Phe 
    2255                 2260                 2265             


Trp Gly  Gly Ser Val Val Ser  Ser Gln Ser Thr Pro  Glu Ser Met 
    2270                 2275                 2280             


Leu Ser  Gly Lys Ser Ser Tyr  Leu Pro Asn Ser Asp  Pro Leu His 
    2285                 2290                 2295             


Gln Ser  Asp Thr Ser Lys Ala  Pro Gly Phe Arg Pro  Pro Leu Gln 
    2300                 2305                 2310             


Arg Pro  Ala Pro Ser Pro Ser  Gly Ile Val Asn Met  Asp Ser Pro 
    2315                 2320                 2325             


Tyr Gly  Ser Val Thr Pro Ser  Ser Thr His Leu Gly  Asn Phe Ala 
    2330                 2335                 2340             


Ser Asn  Ile Ser Gly Gly Gln  Met Tyr Gly Pro Gly  Ala Pro Leu 
    2345                 2350                 2355             


Gly Gly  Ala Pro Ala Ala Ala  Asn Phe Asn Arg Gln  His Phe Ser 
    2360                 2365                 2370             


Pro Leu  Ser Leu Leu Thr Pro  Cys Ser Ser Ala Ser  Asn Asp Ser 
    2375                 2380                 2385             


Ser Ala  Gln Ser Val Ser Ser  Gly Val Arg Ala Pro  Ser Pro Ala 
    2390                 2395                 2400             


Pro Ser  Ser Val Pro Leu Gly  Ser Glu Lys Pro Ser  Asn Val Ser 
    2405                 2410                 2415             


Gln Asp  Arg Lys Val Pro Val  Pro Ile Gly Thr Glu  Arg Ser Ala 
    2420                 2425                 2430             


Arg Ile  Arg Gln Thr Gly Thr  Ser Ala Pro Ser Val  Ile Gly Ser 
    2435                 2440                 2445             


Asn Leu  Ser Thr Ser Val Gly  His Ser Gly Ile Trp  Ser Phe Glu 
    2450                 2455                 2460             


Gly Ile  Gly Gly Asn Gln Asp  Lys Val Asp Trp Cys  Asn Pro Gly 
    2465                 2470                 2475             


Met Gly  Asn Pro Met Ile His  Arg Pro Met Ser Asp  Pro Gly Val 
    2480                 2485                 2490             


Phe Ser  Gln His Gln Ala Met  Glu Arg Asp Ser Thr  Gly Ile Val 
    2495                 2500                 2505             


Thr Pro  Ser Gly Thr Phe His  Gln His Val Pro Ala  Gly Tyr Met 
    2510                 2515                 2520             


Asp Phe  Pro Lys Val Gly Gly  Met Pro Phe Ser Val  Tyr Gly Asn 
    2525                 2530                 2535             


Ala Met  Ile Pro Pro Val Ala  Pro Ile Pro Asp Gly  Ala Gly Gly 
    2540                 2545                 2550             


Pro Ile  Phe Asn Gly Pro His  Ala Ala Asp Pro Ser  Trp Asn Ser 
    2555                 2560                 2565             


Leu Ile  Lys Met Val Ser Ser  Ser Thr Glu Asn Asn  Gly Pro Gln 
    2570                 2575                 2580             


Thr Val  Trp Thr Gly Pro Trp  Ala Pro His Met Asn  Ser Val His 
    2585                 2590                 2595             


Met Asn  Gln Leu Gly 
    2600             


<210> 5959
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 5959
Met Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys 
1               5                   10                  15      


Leu Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp 
            20                  25                  30          


Leu Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile 
        35                  40                  45              


Ala Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg 
    50                  55                  60                  


Arg Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu 
65                  70                  75                  80  


Tyr Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp 
                85                  90                  95      


Asn Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr 
            100                 105                 110         


Lys Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser 
        115                 120                 125             


Tyr Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val 
    130                 135                 140                 


Arg Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys 
145                 150                 155                 160 


Glu His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr 
                165                 170                 175     


Lys Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met 
            180                 185                 190         


Ser Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val 
        195                 200                 205             


Lys Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly 
    210                 215                 220                 


Ile Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe 
225                 230                 235                 240 


Gln Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser 
                245                 250                 255     


Val Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe 
            260                 265                 270         


Gly His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu 
        275                 280                 285             


Ile Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu 
    290                 295                 300                 


Asp Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser 
305                 310                 315                 320 


Glu Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys 
                325                 330                 335     


Leu Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly 
            340                 345                 350         


Ser Leu Leu Ser Ser Gly Ser Gln Glu Ser Asp Ser Ser Gln Ser Ala 
        355                 360                 365             


Lys Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gln Glu Ala Leu Glu 
    370                 375                 380                 


Glu Thr Leu Arg Gln Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu Arg 
385                 390                 395                 400 


Glu Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro Leu Asp Pro 
                405                 410                 415     


Gly Glu Glu Pro Pro Ile Val Arg Arg Arg Ile Gly Thr Ala Phe Lys 
            420                 425                 430         


Leu Asp Glu Gln Lys Ile Leu Pro Lys Gly Glu Glu Ala Glu Leu Glu 
        435                 440                 445             


Arg Leu Glu Arg Glu Phe Ala Ile Gln Ser Gln Ile Thr Glu Ala Ala 
    450                 455                 460                 


Arg Arg Leu Ala Ser Asp Pro Asn Val Ser Lys Lys Leu Lys Lys Gln 
465                 470                 475                 480 


Arg Lys Thr Ser Tyr Leu Asn Ala Leu Lys Lys Leu Gln Glu Ile Glu 
                485                 490                 495     


Asn Ala Ile Asn Glu Asn Arg Ile Lys Ser Gly Lys Lys Pro Thr Gln 
            500                 505                 510         


Arg Ala Ser Leu Ile Ile Asp Asp Gly Asn Ile Ala Ser Glu Asp Ser 
        515                 520                 525             


Ser Leu Ser Asp Ala Leu Val Leu Glu Asp Glu Asp Ser Gln Val Thr 
    530                 535                 540                 


Ser Thr Ile Ser Pro Leu His Ser Pro His Lys Gly Leu Pro Pro Arg 
545                 550                 555                 560 


Pro Pro Ser His Asn Arg Pro Pro Pro Pro Gln Ser Leu Glu Gly Leu 
                565                 570                 575     


Arg Gln Met His Tyr His Arg Asn Asp Tyr Asp Lys Ser Pro Ile Lys 
            580                 585                 590         


Pro Lys Met Trp Ser Glu Ser Ser Leu Asp Glu Pro Tyr Glu Lys Val 
        595                 600                 605             


Lys Lys Arg Ser Ser His Ser His Ser Ser Ser His Lys Arg Phe Pro 
    610                 615                 620                 


Ser Thr Gly Ser Cys Ala Glu Ala Gly Gly Gly Ser Asn Ser Leu Gln 
625                 630                 635                 640 


Asn Ser Pro Ile Arg Gly Leu Pro His Trp Asn Ser Gln Ser Ser Met 
                645                 650                 655     


Pro Ser Thr Pro Asp Leu Arg Val Arg Ser Pro His Tyr Val His Ser 
            660                 665                 670         


Thr Arg Ser Val Asp Ile Ser Pro Thr Arg Leu His Ser Leu Ala Leu 
        675                 680                 685             


His Phe Arg His Arg Ser Ser Ser Leu Glu Ser Gln Gly Lys Leu Leu 
    690                 695                 700                 


Gly Ser Glu Asn Asp Thr Gly Ser Pro Asp Phe Tyr Thr Pro Arg Thr 
705                 710                 715                 720 


Arg Ser Ser Asn Gly Ser Asp Pro Met Asp Asp Cys Ser Ser Cys Thr 
                725                 730                 735     


Ser His Ser Ser Ser Glu His Tyr Tyr Pro Ala Gln Met Asn Ala Asn 
            740                 745                 750         


Tyr Ser Thr Leu Ala Glu Asp Ser Pro Ser Lys Ala Arg Gln Arg Gln 
        755                 760                 765             


Arg Gln Arg Gln Arg Ala Ala Gly Ala Leu Gly Ser Ala Ser Ser Gly 
    770                 775                 780                 


Ser Met Pro Asn Leu Ala Ala Arg Gly Gly Ala Gly Gly Ala Gly Gly 
785                 790                 795                 800 


Ala Gly Gly Gly Val Tyr Leu His Ser Gln Ser Gln Pro Ser Ser Gln 
                805                 810                 815     


Tyr Arg Ile Lys Glu Tyr Pro Leu Tyr Ile Glu Gly Gly Ala Thr Pro 
            820                 825                 830         


Val Val Val Arg Ser Leu Glu Ser Asp Gln Glu Gly His Tyr Ser Val 
        835                 840                 845             


Lys Ala Gln Phe Lys Thr Ser Asn Ser Tyr Thr Ala Gly Gly Leu Phe 
    850                 855                 860                 


Lys Glu Ser Trp Arg Gly Gly Gly Gly Asp Glu Gly Asp Thr Gly Arg 
865                 870                 875                 880 


Leu Thr Pro Ser Arg Ser Gln Ile Leu Arg Thr Pro Ser Leu Gly Arg 
                885                 890                 895     


Glu Gly Ala His Asp Lys Gly Ala Gly Arg Ala Ala Val Ser Asp Glu 
            900                 905                 910         


Leu Arg Gln Trp Tyr Gln Arg Ser Thr Ala Ser His Lys Glu His Ser 
        915                 920                 925             


Arg Leu Ser His Thr Ser Ser Thr Ser Ser Asp Ser Gly Ser Gln Tyr 
    930                 935                 940                 


Ser Thr Ser Ser Gln Ser Thr Phe Val Ala His Ser Arg Val Thr Arg 
945                 950                 955                 960 


Met Pro Gln Met Cys Lys Ala Thr Ser Ala Ala Leu Pro Gln Ser Gln 
                965                 970                 975     


Arg Ser Ser Thr Pro Ser Ser Glu Ile Gly Ala Thr Pro Pro Ser Ser 
            980                 985                 990         


Pro His His Ile Leu Thr Trp Gln  Thr Gly Glu Ala Thr  Glu Asn Ser 
        995                 1000                 1005             


Pro Ile  Leu Asp Gly Ser Glu  Ser Pro Pro His Gln  Ser Thr Asp 
    1010                 1015                 1020             


Glu 
    


<210> 5960
<211> 287
<212> PRT
<213> Homo sapiens

<400> 5960
Met Ser Gln Ala Trp Trp His Thr Ser Val Ser Pro Ala Thr Gln Glu 
1               5                   10                  15      


Ala Lys Ala Gly Gly Leu Leu Gln Pro Arg Arg Gln Arg Leu Trp Leu 
            20                  25                  30          


Lys Arg Cys Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala 
        35                  40                  45              


Leu Ile Ala Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly 
    50                  55                  60                  


Val Gly Phe Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro 
65                  70                  75                  80  


Gln Cys Arg Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser 
                85                  90                  95      


Gly Ala Cys Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu 
            100                 105                 110         


Val Glu Leu Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg 
        115                 120                 125             


Leu Leu Cys Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu 
    130                 135                 140                 


Trp Leu Lys Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala 
145                 150                 155                 160 


Ser Thr Leu Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu 
                165                 170                 175     


Asn Glu Leu Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg 
            180                 185                 190         


His Pro Thr Cys Lys Leu Gln Thr Leu Arg Leu Asp Ser Cys Gly Leu 
        195                 200                 205             


Thr Ala Lys Ala Cys Glu Asn Leu Tyr Phe Thr Leu Gly Ile Asn Gln 
    210                 215                 220                 


Thr Leu Thr Asp Leu Tyr Leu Thr Asn Asn Ala Leu Gly Asp Thr Gly 
225                 230                 235                 240 


Val Arg Leu Leu Cys Lys Arg Leu Ser His Pro Gly Cys Lys Leu Arg 
                245                 250                 255     


Val Leu Trp Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg 
            260                 265                 270         


Leu Ala Ala Leu Arg Val Thr Lys Pro Tyr Leu Asp Ile Gly Cys 
        275                 280                 285         


<210> 5961
<211> 204
<212> PRT
<213> Homo sapiens

<400> 5961
Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ile Ala Ser 
                85                  90                  95      


Val Ile Asn Ser Ala Leu Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val 
            100                 105                 110         


Asp Ile Phe Ala Glu Leu Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr 
        115                 120                 125             


Val Ala Val Ser Ile Ile Ala Lys Lys Glu Val Leu Leu Asp Gln Pro 
    130                 135                 140                 


Gly Arg Glu Glu Glu Asn Gly Ser Thr Ser Lys Thr Ile Val Tyr His 
145                 150                 155                 160 


Leu Asp Glu Gly Val Tyr Gly Ile Phe Asn Ser Val Leu Phe Asp Asn 
                165                 170                 175     


Ile Cys Pro Thr Pro Ile Leu Gln Lys Ser Lys Asn His Ser Pro Cys 
            180                 185                 190         


Tyr Met Ser Leu Glu Ser Ile His Phe Ile Ala Val 
        195                 200                 


<210> 5962
<211> 172
<212> PRT
<213> Homo sapiens

<400> 5962
Met Met Lys Leu Lys Ser Asn Gln Thr Arg Thr Tyr Asp Gly Asp Gly 
1               5                   10                  15      


Tyr Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Ser Glu Glu 
            20                  25                  30          


Glu Val Leu Leu Val Ser Ser Ser Arg His Pro Asp Arg Trp Ile Val 
        35                  40                  45              


Pro Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Ser Val Ala Ala Val 
    50                  55                  60                  


Arg Glu Val Cys Glu Glu Ala Gly Val Lys Gly Thr Leu Gly Arg Leu 
65                  70                  75                  80  


Val Gly Ile Phe Glu Asn Gln Glu Arg Lys His Arg Thr Tyr Val Tyr 
                85                  90                  95      


Val Leu Ile Val Thr Glu Val Leu Glu Asp Trp Glu Asp Ser Val Asn 
            100                 105                 110         


Ile Gly Arg Lys Arg Glu Trp Phe Lys Ile Glu Asp Ala Ile Lys Val 
        115                 120                 125             


Leu Gln Tyr His Lys Pro Val Gln Ala Ser Tyr Phe Glu Thr Leu Arg 
    130                 135                 140                 


Gln Gly Tyr Ser Ala Asn Asn Gly Thr Pro Val Val Ala Thr Thr Tyr 
145                 150                 155                 160 


Ser Val Ser Ala Gln Ser Ser Met Ser Gly Ile Arg 
                165                 170         


<210> 5963
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 5963
Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95      


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110         


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125             


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140                 


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175     


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190         


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205             


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220                 


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240 


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255     


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270         


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285             


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300                 


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320 


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 
                325                 330                 335     


Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala 
            340                 345                 350         


Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu Leu 
        355                 360                 365             


Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser His 
    370                 375                 380                 


Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala Arg Asp Gly His Asp 
385                 390                 395                 400 


Gln His Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met 
                405                 410                 415     


Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 
            420                 425                 430         


Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 
        435                 440                 445             


Ser Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Lys Leu Glu His Ala 
    450                 455                 460                 


Arg Ile Lys Glu Leu Glu Gln Ser Leu Leu Phe Glu Lys Thr Lys Ala 
465                 470                 475                 480 


Asp Lys Leu Gln Arg Glu Leu Glu Asp Thr Arg Val Ala Thr Val Ser 
                485                 490                 495     


Glu Lys Ser Arg Ile Met Glu Leu Glu Lys Asp Leu Ala Leu Arg Val 
            500                 505                 510         


Gln Glu Val Ala Glu Leu Arg Arg Arg Leu Glu Ser Asn Lys Pro Ala 
        515                 520                 525             


Gly Asp Val Asp Met Ser Leu Ser Leu Leu Gln Glu Ile Ser Ser Leu 
    530                 535                 540                 


Gln Glu Lys Leu Glu Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr 
545                 550                 555                 560 


Ser Leu Lys Glu His Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu 
                565                 570                 575     


Ile Lys Ala Leu Tyr Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu 
            580                 585                 590         


Ser Leu Lys Ser Lys Leu Glu His Ala Asn Lys Glu Asn Ser Asp Val 
        595                 600                 605             


Ile Ala Leu Trp Lys Ser Lys Leu Glu Thr Ala Ile Ala Ser His Gln 
    610                 615                 620                 


Gln Ala Met Glu Glu Leu Lys Val Ser Phe Ser Lys Gly Leu Gly Thr 
625                 630                 635                 640 


Glu Thr Ala Glu Phe Ala Glu Leu Lys Thr Gln Ile Glu Lys Met Arg 
                645                 650                 655     


Leu Asp Tyr Gln His Glu Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser 
            660                 665                 670         


Glu Arg Ala Ala His Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu 
        675                 680                 685             


Met Lys Val Ile Lys Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser 
    690                 695                 700                 


Lys Leu Asp Lys Ala Glu Asp Gln His Leu Val Glu Met Glu Asp Thr 
705                 710                 715                 720 


Leu Asn Lys Leu Gln Glu Ala Glu Ile Lys Val Lys Glu Leu Glu Val 
                725                 730                 735     


Leu Gln Ala Lys Cys Asn Glu Gln Thr Lys Val Ile Asp Asn Phe Thr 
            740                 745                 750         


Ser Gln Leu Lys Ala Thr Glu Glu Lys Leu Leu Asp Leu Asp Ala Leu 
        755                 760                 765             


Arg Lys Ala Ser Ser Glu Gly Lys Ser Glu Met Lys Lys Leu Arg Gln 
    770                 775                 780                 


Gln Leu Glu Ala Ala Glu Lys Gln Ile Lys His Leu Glu Ile Glu Lys 
785                 790                 795                 800 


Asn Ala Glu Ser Ser Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly 
                805                 810                 815     


Arg Glu Leu Lys Leu Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser 
            820                 825                 830         


Gln Val Lys Glu Thr Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys 
        835                 840                 845             


Phe Ala Glu Ala Ser Glu Glu Ala Val Ser Val Gln Arg Ser Met Gln 
    850                 855                 860                 


Glu Thr Val Asn Lys Leu His Gln Lys Glu Glu Gln Phe Asn Met Leu 
865                 870                 875                 880 


Ser Ser Asp Leu Glu Lys Leu Arg Glu Asn Leu Ala Asp Met Glu Ala 
                885                 890                 895     


Lys Phe Arg Glu Lys Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys 
            900                 905                 910         


Glu Lys Leu Glu Asn Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp 
        915                 920                 925             


Asn Ser Ser Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu 
    930                 935                 940                 


Arg Asp Val Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn 
945                 950                 955                 960 


Ala Ser Phe Leu Gln Lys Ser Ile Glu Asp Met Thr Val Lys Ala Glu 
                965                 970                 975     


Gln Ser Gln Gln Glu Ala Ala Lys Lys His Glu Glu Glu Lys Lys Glu 
            980                 985                 990         


Leu Glu Arg Lys Leu Ser Asp Leu  Glu Lys Lys Met Glu  Thr Ser His 
        995                 1000                 1005             


Asn Gln  Cys Gln Glu Leu Lys  Ala Arg Tyr Glu Arg  Ala Thr Ser 
    1010                 1015                 1020             


Glu Thr  Lys Thr Lys His Glu  Glu Ile Leu Gln Asn  Leu Gln Lys 
    1025                 1030                 1035             


Thr Leu  Leu Asp Thr Glu Asp  Lys Leu Lys Gly Ala  Arg Glu Glu 
    1040                 1045                 1050             


Asn Ser  Gly Leu Leu Gln Glu  Leu Glu Glu Leu Arg  Lys Gln Ala 
    1055                 1060                 1065             


Asp Lys  Ala Lys Ala Ala Gln  Thr Ala Glu Asp Ala  Met Gln Ile 
    1070                 1075                 1080             


Met Glu  Gln Met Thr Lys Glu  Lys Thr Glu Thr Leu  Ala Ser Leu 
    1085                 1090                 1095             


Glu Asp  Thr Lys Gln Thr Asn  Ala Lys Leu Gln Asn  Glu Leu Asp 
    1100                 1105                 1110             


Thr Leu  Lys Glu Asn Asn Leu  Lys Asn Val Glu Glu  Leu Asn Lys 
    1115                 1120                 1125             


Ser Lys  Glu Leu Leu Thr Val  Glu Asn Gln Lys Met  Glu Glu Phe 
    1130                 1135                 1140             


Arg Lys  Glu Ile Glu Thr Leu  Lys Gln Ala Ala Ala  Gln Lys Ser 
    1145                 1150                 1155             


Gln Gln  Leu Ser Ala Leu Gln  Glu Glu Asn Val Lys  Leu Ala Glu 
    1160                 1165                 1170             


Glu Leu  Gly Arg Ser Arg Asp  Glu Val Thr Ser His  Gln Lys Leu 
    1175                 1180                 1185             


Glu Glu  Glu Arg Ser Val Leu  Asn Asn Gln Leu Leu  Glu Met Lys 
    1190                 1195                 1200             


Lys Arg  Glu Ser Lys Phe Ile  Lys Asp Ala Asp Glu  Glu Lys Ala 
    1205                 1210                 1215             


Ser Leu  Gln Lys Ser Ile Ser  Ile Thr Ser Ala Leu  Leu Thr Glu 
    1220                 1225                 1230             


Lys Asp  Ala Glu Leu Glu Lys  Leu Arg Asn Glu Val  Thr Val Leu 
    1235                 1240                 1245             


Arg Gly  Glu Asn Ala Ser Ala  Lys Ser Leu His Ser  Val Val Gln 
    1250                 1255                 1260             


Thr Leu  Glu Ser Asp Lys Val  Lys Leu Glu Leu Lys  Val Lys Asn 
    1265                 1270                 1275             


Leu Glu  Leu Gln Leu Lys Glu  Asn Lys Arg Gln Leu  Ser Ser Ser 
    1280                 1285                 1290             


Ser Gly  Asn Thr Asp Thr Gln  Ala Asp Glu Asp Glu  Arg Ala Gln 
    1295                 1300                 1305             


Glu Ser  Gln Ile Asp Phe Leu  Asn Ser Val Ile Val  Asp Leu Gln 
    1310                 1315                 1320             


Arg Lys  Asn Gln Asp Leu Lys  Met Lys Val Glu Met  Met Ser Glu 
    1325                 1330                 1335             


Ala Ala  Leu Asn Gly Asn Gly  Asp Asp Leu Asn Asn  Tyr Asp Ser 
    1340                 1345                 1350             


Asp Asp  Gln Glu Lys Gln Ser  Lys Lys Lys Pro Arg  Leu Phe Cys 
    1355                 1360                 1365             


Asp Ile  Cys Asp Cys Phe Asp  Leu His Asp Thr Glu  Asp Cys Pro 
    1370                 1375                 1380             


Thr Gln  Ala Gln Met Ser Glu  Asp Pro Pro His Ser  Thr His His 
    1385                 1390                 1395             


Gly Ser  Arg Gly Glu Glu Arg  Pro Tyr Cys Glu Ile  Cys Glu Met 
    1400                 1405                 1410             


Phe Gly  His Trp Ala Thr Asn  Cys Asn Asp Asp Glu  Thr Phe 
    1415                 1420                 1425         


<210> 5964
<211> 392
<212> PRT
<213> Homo sapiens

<400> 5964
Met Gly Asp Ser Cys Pro Ala Val Thr Phe Arg Ser Gln Lys Glu Asn 
1               5                   10                  15      


Arg Ala Gly Leu Gln Glu Lys Leu Arg Tyr Leu Gln Gln Gln Leu Gln 
            20                  25                  30          


Asp Glu Thr Pro Arg Arg Gln Glu Ala Glu Leu Gln Glu Pro Glu Glu 
        35                  40                  45              


Lys Gln Glu Pro Glu Glu Lys Gln Glu Pro Glu Glu Lys Gln Lys Pro 
    50                  55                  60                  


Glu Ala Gly Leu Ser Trp Asn Ser Leu Gly Pro Ala Ala Thr Ser Gln 
65                  70                  75                  80  


Gly Cys Pro Gly Pro Pro Gly Ser Pro Asp Lys Pro Ser Arg Pro His 
                85                  90                  95      


Gly Leu Val Pro Ala Gly Trp Gly Met Gly Pro Arg Ala Gly Glu Gly 
            100                 105                 110         


Pro Tyr Val Ser Glu Gln Glu Leu Gln Lys Leu Phe Thr Gly Ile Glu 
        115                 120                 125             


Glu Leu Arg Arg Glu Val Ser Ser Leu Thr Ala Arg Trp His Gln Glu 
    130                 135                 140                 


Glu Gly Ala Val Gln Glu Ala Leu Arg Leu Leu Gly Gly Leu Gly Gly 
145                 150                 155                 160 


Arg Val Asp Gly Phe Leu Gly Gln Trp Glu Arg Ala Gln Arg Glu Gln 
                165                 170                 175     


Ala Gln Thr Ala Arg Asp Leu Gln Glu Leu Arg Gly Arg Ala Asp Glu 
            180                 185                 190         


Leu Cys Thr Met Val Glu Arg Ser Ala Val Ser Val Ala Ser Leu Arg 
        195                 200                 205             


Ser Glu Leu Glu Gly Leu Gly Pro Leu Lys Pro Ile Leu Glu Glu Phe 
    210                 215                 220                 


Gly Arg Gln Phe Gln Asn Ser Arg Arg Gly Pro Asp Leu Ser Met Asn 
225                 230                 235                 240 


Leu Asp Arg Ser His Gln Gly Asn Cys Ala Arg Cys Ala Ser Gln Gly 
                245                 250                 255     


Ser Gln Leu Ser Thr Glu Ser Leu Gln Gln Leu Leu Asp Arg Ala Leu 
            260                 265                 270         


Thr Ser Leu Val Asp Glu Val Lys Gln Arg Gly Leu Thr Pro Ala Cys 
        275                 280                 285             


Pro Ser Cys Gln Arg Leu His Lys Lys Ile Leu Glu Leu Glu Arg Gln 
    290                 295                 300                 


Ala Leu Ala Lys His Val Arg Ala Glu Ala Leu Ser Ser Thr Leu Arg 
305                 310                 315                 320 


Leu Ala Gln Asp Glu Ala Leu Arg Ala Lys Asn Leu Leu Leu Thr Asp 
                325                 330                 335     


Lys Met Lys Pro Glu Glu Lys Met Ala Thr Leu Asp His Leu His Leu 
            340                 345                 350         


Lys Met Cys Ser Leu His Asp His Leu Ser Asn Leu Pro Leu Glu Gly 
        355                 360                 365             


Ser Thr Gly Thr Met Gly Gly Gly Ser Ser Ala Gly Thr Pro Pro Lys 
    370                 375                 380                 


Gln Gly Gly Ser Ala Pro Glu Gln 
385                 390         


<210> 5965
<211> 563
<212> PRT
<213> Homo sapiens

<400> 5965
Met Ser Asp Asp Ala Gly Asp Thr Leu Ala Thr Gly Asp Lys Ala Glu 
1               5                   10                  15      


Val Thr Glu Met Pro Asn Ser Asp Ser Leu Pro Glu Asp Ala Glu Val 
            20                  25                  30          


His Cys Asp Ser Ala Ala Val Ser His Glu Pro Thr Pro Ala Asp Pro 
        35                  40                  45              


Arg Gly Glu Gly His Glu Asn Ala Ala Val Gln Gly Ala Gly Ala Ala 
    50                  55                  60                  


Ala Ile Gly Pro Pro Val Gln Pro Gln Asp Ala Asn Ala Leu Glu Pro 
65                  70                  75                  80  


Pro Leu Asn Gly Asp Val Thr Glu Asp Thr Leu Ala Glu Cys Ile Asp 
                85                  90                  95      


Ser Val Ser Leu Glu Ala Glu Pro Arg Ser Glu Ile Pro Leu Gln Glu 
            100                 105                 110         


Gln Asn Tyr Leu Ala Val Asp Ser Pro Pro Ser Gly Gly Gly Trp Ala 
        115                 120                 125             


Gly Trp Gly Ser Trp Gly Lys Ser Leu Leu Ser Ser Ala Ser Ala Thr 
    130                 135                 140                 


Val Gly His Gly Leu Thr Ala Val Lys Glu Lys Ala Gly Ala Thr Leu 
145                 150                 155                 160 


Arg Ile His Gly Val Asn Ser Gly Ser Ser Glu Gly Ala Gln Pro Asn 
                165                 170                 175     


Thr Glu Asn Gly Val Pro Glu Ile Thr Asp Ala Ala Thr Asp Gln Gly 
            180                 185                 190         


Pro Ala Glu Ser Pro Pro Thr Ser Pro Ser Ser Ala Ser Arg Gly Met 
        195                 200                 205             


Leu Ser Ala Ile Thr Asn Val Val Gln Asn Thr Gly Lys Ser Val Leu 
    210                 215                 220                 


Thr Gly Gly Leu Asp Ala Leu Glu Phe Ile Gly Lys Lys Thr Met Asn 
225                 230                 235                 240 


Val Leu Ala Glu Ser Asp Pro Gly Phe Lys Arg Thr Lys Thr Leu Met 
                245                 250                 255     


Glu Arg Thr Val Ser Leu Ser Gln Met Leu Arg Glu Ala Lys Glu Lys 
            260                 265                 270         


Glu Lys Gln Arg Leu Ala Gln Gln Leu Thr Met Glu Arg Thr Ala His 
        275                 280                 285             


Tyr Gly Met Leu Phe Asp Glu Tyr Gln Gly Leu Ser His Leu Glu Ala 
    290                 295                 300                 


Leu Glu Ile Leu Ser Asn Glu Ser Glu Ser Lys Val Gln Ser Phe Leu 
305                 310                 315                 320 


Ala Ser Leu Asp Gly Glu Lys Leu Glu Leu Leu Lys Asn Asp Leu Ile 
                325                 330                 335     


Ser Ile Lys Asp Ile Phe Ala Ala Lys Glu Leu Glu Asn Glu Glu Asn 
            340                 345                 350         


Gln Glu Glu Gln Gly Leu Glu Glu Lys Gly Glu Glu Phe Ala Arg Met 
        355                 360                 365             


Leu Thr Glu Leu Leu Phe Glu Leu His Val Ala Ala Thr Pro Asp Lys 
    370                 375                 380                 


Leu Asn Lys Ala Met Lys Arg Ala His Asp Trp Val Glu Glu Asp Gln 
385                 390                 395                 400 


Thr Val Val Ser Val Asp Val Ala Lys Val Ser Glu Glu Glu Thr Lys 
                405                 410                 415     


Lys Glu Glu Lys Glu Glu Lys Ser Gln Asp Pro Gln Glu Asp Lys Lys 
            420                 425                 430         


Glu Glu Lys Lys Thr Lys Thr Ile Glu Glu Val Tyr Met Ser Ser Ile 
        435                 440                 445             


Glu Ser Leu Ala Glu Val Thr Ala Arg Cys Ile Glu Gln Leu His Lys 
    450                 455                 460                 


Val Ala Glu Leu Ile Leu His Gly Gln Glu Glu Glu Lys Pro Ala Gln 
465                 470                 475                 480 


Asp Gln Ala Lys Val Leu Ile Lys Leu Thr Thr Ala Met Cys Asn Glu 
                485                 490                 495     


Val Ala Ser Leu Ser Lys Lys Phe Thr Asn Ser Leu Thr Thr Val Gly 
            500                 505                 510         


Ser Asn Lys Lys Ala Glu Val Leu Asn Pro Met Ile Ser Ser Val Leu 
        515                 520                 525             


Leu Glu Gly Cys Asn Ser Thr Thr Tyr Ile Gln Asp Ala Phe Gln Leu 
    530                 535                 540                 


Leu Leu Pro Val Leu Gln Val Ser His Ile Gln Thr Ser Cys Leu Lys 
545                 550                 555                 560 


Ala Gln Pro 
            


<210> 5966
<211> 418
<212> PRT
<213> Homo sapiens

<400> 5966
Met Phe Ser Pro Asp Gln Glu Asn His Pro Ser Lys Ala Pro Val Lys 
1               5                   10                  15      


Tyr Gly Glu Leu Ile Val Leu Gly Tyr Asn Gly Ser Leu Pro Asn Gly 
            20                  25                  30          


Asp Arg Gly Arg Arg Lys Ser Arg Phe Ala Leu Phe Lys Arg Pro Lys 
        35                  40                  45              


Ala Asn Gly Val Lys Pro Ser Thr Val His Ile Ala Cys Thr Pro Gln 
    50                  55                  60                  


Ala Ala Lys Ala Ile Ser Asn Lys Asp Gln His Ser Ile Ser Tyr Thr 
65                  70                  75                  80  


Leu Ser Arg Ala Gln Thr Val Val Val Glu Tyr Thr His Asp Ser Asn 
                85                  90                  95      


Thr Asp Met Phe Gln Ile Gly Arg Ser Thr Glu Ser Pro Ile Asp Phe 
            100                 105                 110         


Val Val Thr Asp Thr Val Pro Gly Ser Gln Ser Asn Ser Asp Thr Gln 
        115                 120                 125             


Ser Val Gln Ser Thr Ile Ser Arg Phe Ala Cys Arg Ile Ile Cys Glu 
    130                 135                 140                 


Arg Asn Pro Pro Phe Thr Ala Arg Ile Tyr Ala Ala Gly Phe Asp Ser 
145                 150                 155                 160 


Ser Lys Asn Ile Phe Leu Gly Glu Lys Ala Ala Lys Trp Lys Thr Ser 
                165                 170                 175     


Asp Gly Gln Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val Met His 
            180                 185                 190         


Pro Arg Asn Gly Phe Thr Glu Asp Ser Lys Pro Gly Ile Trp Arg Glu 
        195                 200                 205             


Ile Ser Val Cys Gly Asn Val Phe Ser Leu Arg Glu Thr Arg Ser Ala 
    210                 215                 220                 


Gln Gln Arg Gly Lys Met Val Glu Ile Glu Thr Asn Gln Leu Gln Asp 
225                 230                 235                 240 


Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg Thr Ala 
                245                 250                 255     


Glu Gly Leu Ser His Thr Pro Thr Val Lys His Leu Glu Ala Leu Arg 
            260                 265                 270         


Gln Glu Ile Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Phe Asn Thr 
        275                 280                 285             


Leu Ala Phe Pro Ser Met Lys Arg Lys Asp Val Val Asp Glu Lys Gln 
    290                 295                 300                 


Pro Trp Val Tyr Leu Asn Cys Gly His Val His Gly Tyr His Asn Trp 
305                 310                 315                 320 


Gly Asn Lys Glu Glu Arg Asp Gly Lys Asp Arg Glu Cys Pro Met Cys 
                325                 330                 335     


Arg Ser Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Cys Glu Ala Gly 
            340                 345                 350         


Phe Tyr Val Asp Ala Gly Pro Pro Thr His Ala Phe Ser Pro Cys Gly 
        355                 360                 365             


His Val Cys Ser Glu Lys Thr Thr Ala Tyr Trp Ser Gln Ile Pro Leu 
    370                 375                 380                 


Pro His Gly Thr His Thr Phe His Ala Ala Cys Pro Phe Cys Ala His 
385                 390                 395                 400 


Gln Leu Ala Gly Glu Gln Gly Tyr Ile Arg Leu Ile Phe Gln Gly Pro 
                405                 410                 415     


Leu Asp 
        


<210> 5967
<211> 1320
<212> PRT
<213> Homo sapiens

<400> 5967
Met Gln Asp Asp Ser Ile Glu Ala Ser Thr Ser Ile Ser Gln Leu Leu 
1               5                   10                  15      


Arg Glu Ser Tyr Leu Ala Glu Thr Arg His Arg Gly Asn Asn Glu Arg 
            20                  25                  30          


Ser Arg Ala Glu Pro Ser Ser Asn Pro Cys His Phe Gly Ser Pro Ser 
        35                  40                  45              


Gly Ala Ala Glu Gly Gly Gly Gly Gln Asp Asp Leu Pro Asp Leu Ser 
    50                  55                  60                  


Ala Phe Leu Ser Gln Glu Glu Leu Asp Glu Ser Val Asn Leu Ala Arg 
65                  70                  75                  80  


Leu Ala Ile Asn Tyr Asp Pro Leu Glu Lys Ala Asp Glu Thr Gln Ala 
                85                  90                  95      


Arg Lys Arg Leu Ser Pro Asp Gln Met Lys His Ser Pro Asn Leu Ser 
            100                 105                 110         


Phe Glu Pro Asn Phe Cys Gln Asp Asn Pro Arg Ser Pro Thr Ser Ser 
        115                 120                 125             


Lys Glu Ser Pro Gln Glu Ala Lys Arg Pro Gln Tyr Cys Ser Glu Thr 
    130                 135                 140                 


Gln Ser Lys Lys Val Phe Leu Asn Lys Ala Ala Asp Phe Ile Glu Glu 
145                 150                 155                 160 


Leu Ser Ser Leu Phe Lys Ser His Ser Ser Lys Arg Ile Arg Pro Arg 
                165                 170                 175     


Ala Cys Lys Asn His Lys Ser Lys Leu Glu Ser Gln Asn Lys Val Met 
            180                 185                 190         


Gln Glu Asn Ser Ser Ser Phe Ser Asp Leu Ser Glu Arg Arg Glu Arg 
        195                 200                 205             


Ser Ser Val Pro Ile Pro Ile Pro Ala Asp Thr Arg Asp Asn Glu Val 
    210                 215                 220                 


Asn His Ala Leu Glu Gln Gln Glu Ala Lys Arg Arg Glu Ala Glu Gln 
225                 230                 235                 240 


Ala Ala Ser Glu Ala Ala Gly Gly Asp Thr Thr Pro Gly Ser Ser Pro 
                245                 250                 255     


Ser Ser Leu Tyr Tyr Glu Glu Pro Leu Gly Gln Pro Pro Arg Phe Thr 
            260                 265                 270         


Gln Lys Leu Arg Ser Arg Glu Val Pro Glu Gly Thr Arg Val Gln Leu 
        275                 280                 285             


Asp Cys Ile Val Val Gly Ile Pro Pro Pro Gln Val Arg Trp Tyr Cys 
    290                 295                 300                 


Glu Gly Lys Glu Leu Glu Asn Ser Pro Asp Ile His Ile Val Gln Ala 
305                 310                 315                 320 


Gly Asn Leu His Ser Leu Thr Ile Ala Glu Ala Phe Glu Glu Asp Thr 
                325                 330                 335     


Gly Arg Tyr Ser Cys Phe Ala Ser Asn Ile Tyr Gly Thr Asp Ser Thr 
            340                 345                 350         


Ser Ala Glu Ile Tyr Ile Glu Gly Val Ser Ser Ser Asp Ser Glu Gly 
        355                 360                 365             


Asp Pro Asn Lys Glu Glu Met Asn Arg Ile Gln Lys Pro Asn Glu Val 
    370                 375                 380                 


Ser Ser Pro Pro Thr Thr Ser Ala Val Ile Pro Pro Ala Val Pro Gln 
385                 390                 395                 400 


Ala Gln His Leu Val Ala Gln Pro Arg Val Ala Thr Ile Gln Gln Cys 
                405                 410                 415     


Gln Ser Pro Thr Asn Tyr Leu Gln Gly Leu Asp Gly Lys Pro Ile Ile 
            420                 425                 430         


Ala Ala Pro Val Phe Thr Lys Met Leu Gln Asn Leu Ser Ala Ser Glu 
        435                 440                 445             


Gly Gln Leu Val Val Phe Glu Cys Arg Val Lys Gly Ala Pro Ser Pro 
    450                 455                 460                 


Lys Val Glu Trp Tyr Arg Glu Gly Thr Leu Ile Glu Asp Ser Pro Asp 
465                 470                 475                 480 


Phe Arg Ile Leu Gln Lys Lys Pro Arg Ser Met Ala Glu Pro Glu Glu 
                485                 490                 495     


Ile Cys Thr Leu Val Ile Ala Glu Val Phe Ala Glu Asp Ser Gly Cys 
            500                 505                 510         


Phe Thr Cys Thr Ala Ser Asn Lys Tyr Gly Thr Val Ser Ser Ile Ala 
        515                 520                 525             


Gln Leu His Val Arg Gly Asn Glu Asp Leu Ser Asn Asn Gly Ser Leu 
    530                 535                 540                 


His Ser Ala Asn Ser Thr Thr Asn Leu Ala Ala Ile Glu Pro Gln Pro 
545                 550                 555                 560 


Ser Pro Pro His Ser Glu Pro Pro Ser Val Glu Gln Pro Pro Lys Pro 
                565                 570                 575     


Lys Leu Glu Gly Val Leu Val Asn His Asn Glu Pro Arg Ser Ser Ser 
            580                 585                 590         


Arg Ile Gly Leu Arg Val His Phe Asn Leu Pro Glu Asp Asp Lys Gly 
        595                 600                 605             


Ser Glu Ala Ser Ser Glu Ala Gly Val Val Thr Thr Arg Gln Thr Arg 
    610                 615                 620                 


Pro Asp Ser Phe Gln Glu Arg Phe Asn Gly Gln Ala Thr Lys Thr Pro 
625                 630                 635                 640 


Glu Pro Ser Ser Pro Val Lys Glu Pro Pro Pro Val Leu Ala Lys Pro 
                645                 650                 655     


Lys Leu Asp Ser Thr Gln Leu Gln Gln Leu His Asn Gln Val Leu Leu 
            660                 665                 670         


Glu Gln His Gln Leu Gln Asn Pro Pro Pro Ser Ser Pro Lys Glu Phe 
        675                 680                 685             


Pro Phe Ser Met Thr Val Leu Asn Ser Asn Ala Pro Pro Ala Val Thr 
    690                 695                 700                 


Thr Ser Ser Lys Gln Val Lys Ala Pro Ser Ser Gln Thr Phe Ser Leu 
705                 710                 715                 720 


Ala Arg Pro Lys Tyr Phe Phe Pro Ser Thr Asn Thr Thr Ala Ala Thr 
                725                 730                 735     


Val Ala Pro Ser Ser Ser Pro Val Phe Thr Leu Ser Ser Thr Pro Gln 
            740                 745                 750         


Thr Ile Gln Arg Thr Val Ser Lys Glu Ser Leu Leu Val Ser His Pro 
        755                 760                 765             


Ser Val Gln Thr Lys Ser Pro Gly Gly Leu Ser Ile Gln Asn Glu Pro 
    770                 775                 780                 


Leu Pro Pro Gly Pro Thr Glu Pro Thr Pro Pro Pro Phe Thr Phe Ser 
785                 790                 795                 800 


Ile Pro Ser Gly Asn Gln Phe Gln Pro Arg Cys Val Ser Pro Ile Pro 
                805                 810                 815     


Val Ser Pro Thr Ser Arg Ile Gln Asn Pro Val Ala Phe Leu Ser Ser 
            820                 825                 830         


Val Leu Pro Ser Leu Pro Ala Ile Pro Pro Thr Asn Ala Met Gly Leu 
        835                 840                 845             


Pro Arg Ser Ala Pro Ser Met Pro Ser Gln Gly Leu Ala Lys Lys Asn 
    850                 855                 860                 


Thr Lys Ser Pro Gln Pro Val Asn Asp Asp Asn Ile Arg Glu Thr Lys 
865                 870                 875                 880 


Asn Ala Val Ile Arg Asp Leu Gly Lys Lys Ile Thr Phe Ser Asp Val 
                885                 890                 895     


Arg Pro Asn Gln Gln Glu Tyr Lys Ile Ser Ser Phe Glu Gln Arg Leu 
            900                 905                 910         


Met Asn Glu Ile Glu Phe Arg Leu Glu Arg Thr Pro Val Asp Glu Ser 
        915                 920                 925             


Asp Asp Glu Ile Gln His Asp Glu Ile Pro Thr Gly Lys Cys Ile Ala 
    930                 935                 940                 


Pro Ile Phe Asp Lys Arg Leu Lys His Phe Arg Val Thr Glu Gly Ser 
945                 950                 955                 960 


Pro Val Thr Phe Thr Cys Lys Ile Val Gly Ile Pro Val Pro Lys Val 
                965                 970                 975     


Tyr Trp Phe Lys Asp Gly Lys Gln Ile Ser Lys Arg Asn Glu His Cys 
            980                 985                 990         


Lys Met Arg Arg Glu Gly Asp Gly  Thr Cys Ser Leu His  Ile Glu Ser 
        995                 1000                 1005             


Thr Thr  Ser Asp Asp Asp Gly  Asn Tyr Thr Ile Met  Ala Ala Asn 
    1010                 1015                 1020             


Pro Gln  Gly Arg Ile Ser Cys  Ser Gly His Leu Met  Val Gln Ser 
    1025                 1030                 1035             


Leu Pro  Ile Arg Ser Arg Leu  Thr Ser Ala Gly Gln  Ser His Arg 
    1040                 1045                 1050             


Gly Arg  Ser Arg Val Gln Glu  Arg Asp Lys Glu Pro  Leu Gln Glu 
    1055                 1060                 1065             


Arg Phe  Phe Arg Pro His Phe  Leu Gln Ala Pro Gly  Asp Met Val 
    1070                 1075                 1080             


Ala His  Glu Gly Arg Leu Cys  Arg Leu Asp Cys Lys  Val Ser Gly 
    1085                 1090                 1095             


Leu Pro  Pro Pro Glu Leu Thr  Trp Leu Leu Asn Gly  Gln Pro Val 
    1100                 1105                 1110             


Leu Pro  Asp Ala Ser His Lys  Met Leu Val Arg Glu  Thr Gly Val 
    1115                 1120                 1125             


His Ser  Leu Leu Ile Asp Pro  Leu Thr Gln Arg Asp  Ala Gly Thr 
    1130                 1135                 1140             


Tyr Lys  Cys Ile Ala Thr Asn  Lys Thr Gly Gln Asn  Ser Phe Ser 
    1145                 1150                 1155             


Leu Glu  Leu Ser Val Val Ala  Lys Glu Val Lys Lys  Ala Pro Val 
    1160                 1165                 1170             


Ile Leu  Glu Lys Leu Gln Asn  Cys Gly Val Pro Glu  Gly His Pro 
    1175                 1180                 1185             


Val Arg  Leu Glu Cys Arg Val  Ile Gly Met Pro Pro  Pro Val Phe 
    1190                 1195                 1200             


Tyr Trp  Lys Lys Asp Asn Glu  Thr Ile Pro Cys Thr  Arg Glu Arg 
    1205                 1210                 1215             


Ile Ser  Met His Gln Asp Thr  Thr Gly Tyr Ala Cys  Leu Leu Ile 
    1220                 1225                 1230             


Gln Pro  Ala Lys Lys Ser Asp  Ala Gly Trp Tyr Thr  Leu Ser Ala 
    1235                 1240                 1245             


Lys Asn  Glu Ala Gly Ile Val  Ser Cys Thr Ala Arg  Leu Asp Ile 
    1250                 1255                 1260             


Tyr Ala  Gln Trp His His Gln  Ile Pro Pro Pro Met  Ser Val Arg 
    1265                 1270                 1275             


Pro Ser  Gly Ser Arg Tyr Gly  Ser Leu Thr Ser Lys  Gly Leu Asp 
    1280                 1285                 1290             


Ile Phe  Ser Ala Phe Ser Ser  Met Glu Ser Thr Met  Val Tyr Ser 
    1295                 1300                 1305             


Cys Ser  Ser Arg Ser Val Val  Glu Ser Asp Glu Leu  
    1310                 1315                 1320 


<210> 5968
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 5968
Met Ala Ser Cys Ala Ser Ile Asp Ile Glu Asp Ala Thr Gln His Leu 
1               5                   10                  15      


Arg Asp Ile Leu Lys Leu Asp Arg Pro Ala Gly Gly Pro Ser Ala Glu 
            20                  25                  30          


Ser Pro Arg Pro Ser Ser Ala Tyr Asn Gly Asp Leu Asn Gly Leu Leu 
        35                  40                  45              


Val Pro Asp Pro Leu Cys Ser Gly Asp Ser Thr Ser Ala Asn Lys Thr 
    50                  55                  60                  


Gly Leu Arg Thr Met Pro Pro Ile Asn Leu Gln Glu Lys Gln Val Ile 
65                  70                  75                  80  


Cys Leu Ser Gly Asp Asp Ser Ser Thr Cys Ile Gly Ile Leu Ala Lys 
                85                  90                  95      


Glu Val Glu Ile Val Ala Ser Ser Asp Ser Ser Ile Ser Ser Lys Ala 
            100                 105                 110         


Arg Gly Ser Asn Lys Val Lys Ile Gln Pro Val Ala Lys Tyr Asp Trp 
        115                 120                 125             


Glu Gln Lys Tyr Tyr Tyr Gly Asn Leu Ile Ala Val Ser Asn Ser Phe 
    130                 135                 140                 


Leu Ala Tyr Ala Ile Arg Ala Ala Asn Asn Gly Ser Ala Met Val Arg 
145                 150                 155                 160 


Val Ile Ser Val Ser Thr Ser Glu Arg Thr Leu Leu Lys Gly Phe Thr 
                165                 170                 175     


Gly Ser Val Ala Asp Leu Ala Phe Ala His Leu Asn Ser Pro Gln Leu 
            180                 185                 190         


Ala Cys Leu Asp Glu Ala Gly Asn Leu Phe Val Trp Arg Leu Ala Leu 
        195                 200                 205             


Val Asn Gly Lys Ile Gln Glu Glu Ile Leu Val His Ile Arg Gln Pro 
    210                 215                 220                 


Glu Gly Thr Pro Leu Asn His Phe Arg Arg Ile Ile Trp Cys Pro Phe 
225                 230                 235                 240 


Ile Pro Glu Glu Ser Glu Asp Cys Cys Glu Glu Ser Ser Pro Thr Val 
                245                 250                 255     


Ala Leu Leu His Glu Asp Arg Ala Glu Val Trp Asp Leu Asp Met Leu 
            260                 265                 270         


Arg Ser Ser His Ser Thr Trp Pro Val Asp Val Ser Gln Ile Lys Gln 
        275                 280                 285             


Gly Phe Ile Val Val Lys Gly His Ser Thr Cys Leu Ser Glu Gly Ala 
    290                 295                 300                 


Leu Ser Pro Asp Gly Thr Val Leu Ala Thr Ala Ser His Asp Gly Tyr 
305                 310                 315                 320 


Val Lys Phe Trp Gln Ile Tyr Ile Glu Gly Gln Asp Glu Pro Arg Cys 
                325                 330                 335     


Leu His Glu Trp Lys Pro His Asp Gly Arg Pro Leu Ser Cys Leu Leu 
            340                 345                 350         


Phe Cys Asp Asn His Lys Lys Gln Asp Pro Asp Val Pro Phe Trp Arg 
        355                 360                 365             


Phe Leu Ile Thr Gly Ala Asp Gln Asn Arg Glu Leu Lys Met Trp Cys 
    370                 375                 380                 


Thr Val Ser Trp Thr Cys Leu Gln Thr Ile Arg Phe Ser Pro Asp Ile 
385                 390                 395                 400 


Phe Ser Ser Val Ser Val Pro Pro Ser Leu Lys Val Cys Leu Asp Leu 
                405                 410                 415     


Ser Ala Glu Tyr Leu Ile Leu Ser Asp Val Gln Arg Lys Val Leu Tyr 
            420                 425                 430         


Val Met Glu Leu Leu Gln Asn Gln Glu Glu Gly His Ala Cys Phe Ser 
        435                 440                 445             


Ser Ile Ser Glu Phe Leu Leu Thr His Pro Val Leu Ser Phe Gly Ile 
    450                 455                 460                 


Gln Val Val Ser Arg Cys Arg Leu Arg His Thr Glu Val Leu Pro Ala 
465                 470                 475                 480 


Glu Glu Glu Asn Asp Ser Leu Gly Ala Asp Gly Thr His Gly Ala Gly 
                485                 490                 495     


Ala Met Glu Ser Ala Ala Gly Val Leu Ile Lys Leu Phe Cys Val His 
            500                 505                 510         


Thr Lys Ala Leu Gln Asp Val Gln Ile Arg Phe Gln Pro Gln Leu Asn 
        515                 520                 525             


Pro Asp Val Val Ala Pro Leu Pro Thr His Thr Ala His Glu Asp Phe 
    530                 535                 540                 


Thr Phe Gly Glu Ser Arg Pro Glu Leu Gly Ser Glu Gly Leu Gly Ser 
545                 550                 555                 560 


Ala Ala His Gly Ser Gln Pro Asp Leu Arg Arg Ile Val Glu Leu Pro 
                565                 570                 575     


Ala Pro Ala Asp Phe Leu Ser Leu Ser Ser Glu Thr Lys Pro Lys Leu 
            580                 585                 590         


Met Thr Pro Asp Ala Phe Met Thr Pro Ser Ala Ser Leu Gln Gln Ile 
        595                 600                 605             


Thr Ala Ser Pro Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
    610                 615                 620                 


Ser Ser Ser Ser Ser Leu Thr Ala Val Ser Ala Met Ser Ser Thr Ser 
625                 630                 635                 640 


Ala Val Asp Pro Ser Leu Thr Arg Pro Pro Glu Glu Leu Thr Leu Ser 
                645                 650                 655     


Pro Lys Leu Gln Leu Asp Gly Ser Leu Thr Met Ser Ser Ser Gly Ser 
            660                 665                 670         


Leu Gln Ala Ser Pro Arg Gly Leu Leu Pro Gly Leu Leu Pro Ala Pro 
        675                 680                 685             


Ala Asp Lys Leu Thr Pro Lys Gly Pro Gly Gln Val Pro Thr Ala Thr 
    690                 695                 700                 


Ser Ala Leu Ser Leu Glu Leu Gln Glu Val Glu Pro Leu Gly Leu Pro 
705                 710                 715                 720 


Gln Ala Ser Pro Ser Arg Thr Arg Ser Pro Asp Val Ile Ser Ser Ala 
                725                 730                 735     


Ser Thr Ala Leu Ser Gln Asp Ile Pro Glu Ile Ala Ser Glu Ala Leu 
            740                 745                 750         


Ser Arg Gly Phe Gly Ser Ser Ala Pro Glu Gly Leu Glu Pro Asp Ser 
        755                 760                 765             


Met Ala Ser Ala Ala Ser Ala Leu His Leu Leu Ser Pro Arg Pro Arg 
    770                 775                 780                 


Pro Gly Pro Glu Leu Gly Pro Gln Leu Gly Leu Asp Gly Gly Pro Gly 
785                 790                 795                 800 


Asp Gly Asp Arg His Asn Thr Pro Ser Leu Leu Glu Ala Ala Leu Thr 
                805                 810                 815     


Gln Glu Ala Ser Thr Pro Asp Ser Gln Val Trp Pro Thr Ala Pro Asp 
            820                 825                 830         


Ile Thr Arg Glu Thr Cys Ser Thr Leu Ala Glu Ser Pro Arg Asn Gly 
        835                 840                 845             


Leu Gln Glu Lys His Lys Ser Leu Ala Phe His Arg Pro Pro Tyr His 
    850                 855                 860                 


Leu Leu Gln Gln Arg Asp Ser Gln Asp Ala Ser Ala Glu Gln Ser Asp 
865                 870                 875                 880 


His Asp Asp Glu Val Ala Ser Leu Ala Ser Ala Ser Gly Gly Phe Gly 
                885                 890                 895     


Thr Lys Val Pro Ala Pro Arg Leu Pro Ala Lys Asp Trp Lys Thr Lys 
            900                 905                 910         


Gly Ser Pro Arg Thr Ser Pro Lys Leu Lys Arg Lys Ser Lys Lys Asp 
        915                 920                 925             


Asp Gly Asp Ala Ala Met Gly Ser Arg Leu Thr Glu His Gln Val Ala 
    930                 935                 940                 


Glu Pro Pro Glu Asp Trp Pro Ala Leu Ile Trp Gln Gln Gln Arg Glu 
945                 950                 955                 960 


Leu Ala Glu Leu Arg His Ser Gln Glu Glu Leu Leu Gln Arg Leu Cys 
                965                 970                 975     


Thr Gln Leu Glu Gly Leu Gln Ser Thr Val Thr Gly His Val Glu Arg 
            980                 985                 990         


Ala Leu Glu Thr Arg His Glu Gln  Glu Gln Arg Arg Leu  Glu Arg Ala 
        995                 1000                 1005             


Leu Ala  Glu Gly Gln Gln Arg  Gly Gly Gln Leu Gln  Glu Gln Leu 
    1010                 1015                 1020             


Thr Gln  Gln Leu Ser Gln Ala  Leu Ser Ser Ala Val  Ala Gly Arg 
    1025                 1030                 1035             


Leu Glu  Arg Ser Ile Arg Asp  Glu Ile Lys Lys Thr  Val Pro Pro 
    1040                 1045                 1050             


Cys Val  Ser Arg Ser Leu Glu  Pro Met Ala Gly Gln  Leu Ser Asn 
    1055                 1060                 1065             


Ser Val  Ala Thr Lys Leu Thr  Ala Val Glu Gly Ser  Met Lys Glu 
    1070                 1075                 1080             


Asn Ile  Ser Lys Leu Leu Lys  Ser Lys Asn Leu Thr  Asp Ala Ile 
    1085                 1090                 1095             


Ala Arg  Ala Ala Ala Asp Thr  Leu Gln Gly Pro Met  Gln Ala Ala 
    1100                 1105                 1110             


Tyr Arg  Glu Ala Phe Gln Ser  Val Val Leu Pro Ala  Phe Glu Lys 
    1115                 1120                 1125             


Ser Cys  Gln Ala Met Phe Gln  Gln Ile Asn Asp Ser  Phe Arg Leu 
    1130                 1135                 1140             


Gly Thr  Gln Glu Tyr Leu Gln  Gln Leu Glu Ser His  Met Lys Ser 
    1145                 1150                 1155             


Arg Lys  Ala Arg Glu Gln Glu  Ala Arg Glu Pro Val  Leu Ala Gln 
    1160                 1165                 1170             


Leu Arg  Gly Leu Val Ser Thr  Leu Gln Ser Ala Thr  Glu Gln Met 
    1175                 1180                 1185             


Ala Ala  Thr Val Ala Gly Ser  Val Arg Ala Glu Val  Gln His Gln 
    1190                 1195                 1200             


Leu His  Val Ala Val Gly Ser  Leu Gln Glu Ser Ile  Leu Ala Gln 
    1205                 1210                 1215             


Val Gln  Arg Ile Val Lys Gly  Glu Val Ser Val Ala  Leu Lys Glu 
    1220                 1225                 1230             


Gln Gln  Ala Ala Val Thr Ser  Ser Ile Met Gln Ala  Met Arg Ser 
    1235                 1240                 1245             


Ala Ala  Gly Thr Pro Val Pro  Ser Ala His Leu Asp  Cys Gln Ala 
    1250                 1255                 1260             


Gln Gln  Ala His Ile Leu Gln  Leu Leu Gln Gln Gly  His Leu Asn 
    1265                 1270                 1275             


Gln Ala  Phe Gln Gln Ala Leu  Thr Ala Ala Asp Leu  Asn Leu Val 
    1280                 1285                 1290             


Leu Tyr  Val Cys Glu Thr Val  Asp Pro Ala Gln Val  Phe Gly Gln 
    1295                 1300                 1305             


Pro Pro  Cys Pro Leu Ser Gln  Pro Val Leu Leu Ser  Leu Ile Gln 
    1310                 1315                 1320             


Gln Leu  Ala Ser Asp Leu Gly  Thr Arg Thr Asp Leu  Lys Leu Ser 
    1325                 1330                 1335             


Tyr Leu  Glu Glu Ala Val Met  His Leu Asp His Ser  Asp Pro Ile 
    1340                 1345                 1350             


Thr Arg  Asp His Met Gly Ser  Val Met Ala Gln Val  Arg Gln Lys 
    1355                 1360                 1365             


Leu Phe  Gln Phe Leu Gln Ala  Glu Pro His Asn Ser  Leu Gly Lys 
    1370                 1375                 1380             


Ala Ala  Arg Arg Leu Ser Leu  Met Leu His Gly Leu  Val Thr Pro 
    1385                 1390                 1395             


Ser Leu  Pro 
    1400     


<210> 5969
<211> 191
<212> PRT
<213> Homo sapiens

<400> 5969
Met Ser Ser Gly Ala Asp Gly Gly Gly Gly Ala Ala Val Ala Ala Arg 
1               5                   10                  15      


Ser Asp Lys Gly Ser Pro Gly Glu Asp Gly Phe Val Pro Ser Ala Leu 
            20                  25                  30          


Gly Thr Arg Glu His Trp Asp Ala Val Tyr Glu Arg Glu Leu Gln Thr 
        35                  40                  45              


Phe Arg Glu Tyr Gly Asp Thr Gly Glu Ile Trp Phe Gly Glu Glu Ser 
    50                  55                  60                  


Met Asn Arg Leu Ile Arg Trp Met Gln Lys His Lys Ile Pro Leu Asp 
65                  70                  75                  80  


Ala Ser Val Leu Asp Ile Gly Thr Gly Asn Gly Val Phe Leu Val Glu 
                85                  90                  95      


Leu Ala Lys Phe Gly Phe Ser Asn Ile Thr Gly Ile Asp Tyr Ser Pro 
            100                 105                 110         


Ser Ala Ile Gln Leu Ser Gly Ser Ile Ile Glu Lys Glu Gly Leu Ser 
        115                 120                 125             


Asn Ile Lys Leu Lys Val Glu Asp Phe Leu Asn Leu Ser Thr Gln Leu 
    130                 135                 140                 


Ser Gly Phe His Ile Cys Ile Asp Lys Gly Thr Phe Asp Ala Ile Ser 
145                 150                 155                 160 


Leu Asn Pro Asp Asn Ala Ile Glu Lys Arg Lys Gln Tyr Val Lys Ser 
                165                 170                 175     


Leu Ser Arg Val Leu Lys Val Lys Gly Phe Phe Asn Asn Val Met 
            180                 185                 190     


<210> 5970
<211> 873
<212> PRT
<213> Homo sapiens

<400> 5970
Met Gly Asn Arg Glu Met Glu Glu Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Leu Gly Gln Ser Cys Leu Leu Glu Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Thr Ser Lys Ala Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Asp Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Met Asn 
            100                 105                 110         


Lys Gly Ile Ser Ser Ile Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Glu Met Ile 
145                 150                 155                 160 


Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val Thr Pro 
                165                 170                 175     


Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu His Glu Val Glu Ala Tyr Lys Asn Phe Lys Pro Glu 
305                 310                 315                 320 


Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
            340                 345                 350         


Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Ile Val Lys Lys Gln 
                405                 410                 415     


Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu Val Ile 
            420                 425                 430         


Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Lys Leu Ala Asn 
        435                 440                 445             


Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Thr Thr Val 
            500                 505                 510         


Gly Asn Gln Gly Thr Asn Leu Pro Pro Ser Arg Gln Ile Val Ile Arg 
        515                 520                 525             


Lys Gly Trp Leu Thr Ile Ser Asn Ile Gly Ile Met Lys Gly Gly Ser 
    530                 535                 540                 


Lys Gly Tyr Trp Phe Val Leu Thr Ala Glu Ser Leu Ser Trp Tyr Lys 
545                 550                 555                 560 


Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met Leu Pro Leu Asp Asn Leu 
                565                 570                 575     


Lys Val Arg Asp Val Glu Lys Ser Phe Met Ser Ser Lys His Ile Phe 
            580                 585                 590         


Ala Leu Phe Asn Thr Glu Gln Arg Asn Val Tyr Lys Asp Tyr Arg Phe 
        595                 600                 605             


Leu Glu Leu Ala Cys Asp Ser Gln Glu Asp Val Asp Ser Trp Lys Ala 
    610                 615                 620                 


Ser Leu Leu Arg Ala Gly Val Tyr Pro Asp Lys Ser Val Met Asn Lys 
625                 630                 635                 640 


Lys Ala Glu Asn Asp Glu Asn Gly Gln Ala Glu Asn Phe Ser Met Asp 
                645                 650                 655     


Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser 
            660                 665                 670         


Tyr Met Ser Ile Ile Asn Lys Cys Ile Arg Asp Leu Ile Pro Lys Thr 
        675                 680                 685             


Ile Met His Leu Met Ile Asn Asn Val Lys Asp Phe Ile Asn Ser Glu 
    690                 695                 700                 


Leu Leu Ala Gln Leu Tyr Ser Ser Glu Asp Gln Asn Thr Leu Met Glu 
705                 710                 715                 720 


Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp Glu Met Leu Arg Met Tyr 
                725                 730                 735     


Gln Ala Leu Lys Glu Ala Leu Gly Ile Ile Gly Asp Ile Ser Thr Ala 
            740                 745                 750         


Thr Val Ser Thr Pro Ala Pro Pro Pro Val Asp Asp Ser Trp Ile Gln 
        755                 760                 765             


His Ser Arg Arg Ser Pro Pro Pro Ser Pro Thr Thr Gln Arg Arg Pro 
    770                 775                 780                 


Thr Leu Ser Ala Pro Leu Ala Arg Pro Thr Ser Gly Arg Gly Pro Ala 
785                 790                 795                 800 


Pro Ala Ile Pro Ser Pro Gly Pro His Ser Gly Ala Pro Pro Val Pro 
                805                 810                 815     


Phe Arg Pro Gly Pro Leu Pro Pro Phe Pro Ser Ser Ser Asp Ser Phe 
            820                 825                 830         


Gly Ala Pro Pro Gln Val Pro Ser Arg Pro Thr Arg Ala Pro Pro Ser 
        835                 840                 845             


Val Pro Ser Arg Arg Pro Pro Pro Ser Pro Thr Arg Pro Thr Ile Ile 
    850                 855                 860                 


Arg Pro Leu Glu Ser Ser Leu Leu Asp 
865                 870             


<210> 5971
<211> 1036
<212> PRT
<213> Homo sapiens

<400> 5971
Met Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His 
1               5                   10                  15      


Gly Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu 
            20                  25                  30          


Ala Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp Arg 
        35                  40                  45              


Thr Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln 
    50                  55                  60                  


Arg His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu 
65                  70                  75                  80  


Gly Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu 
                85                  90                  95      


Thr Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr 
            100                 105                 110         


Arg Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe 
        115                 120                 125             


Leu Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile 
    130                 135                 140                 


Gly Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg 
145                 150                 155                 160 


Leu Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro 
                165                 170                 175     


Leu Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg 
            180                 185                 190         


Leu Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val 
        195                 200                 205             


Ala Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys 
    210                 215                 220                 


Arg Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys 
225                 230                 235                 240 


Lys Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn 
                245                 250                 255     


Leu Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser 
            260                 265                 270         


Gly Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly 
        275                 280                 285             


Phe Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu 
    290                 295                 300                 


Asp Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg 
305                 310                 315                 320 


Ala Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly 
                325                 330                 335     


Met Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala 
            340                 345                 350         


Glu Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe 
        355                 360                 365             


Arg Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro 
    370                 375                 380                 


Arg Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr 
                405                 410                 415     


Glu Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly 
            420                 425                 430         


Ala Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser 
        435                 440                 445             


Val Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala 
    450                 455                 460                 


Ala Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr 
465                 470                 475                 480 


Glu Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg 
                485                 490                 495     


Ser Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val 
            500                 505                 510         


Phe Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu 
        515                 520                 525             


Leu Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr 
    530                 535                 540                 


Gln Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val 
545                 550                 555                 560 


Cys Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His 
                565                 570                 575     


Thr Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu 
            580                 585                 590         


Ala Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu 
        595                 600                 605             


Gln Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu 
    610                 615                 620                 


Ser Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu 
                645                 650                 655     


Leu Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser 
            660                 665                 670         


Leu Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg 
        675                 680                 685             


Ser Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn 
    690                 695                 700                 


Ser Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile 
705                 710                 715                 720 


Asn Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn Thr Val Arg Asp 
                725                 730                 735     


Asp Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser Asn Arg Thr Leu 
            740                 745                 750         


Ser Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro Met Gly Ala Gln 
        755                 760                 765             


Arg Met Ala Asp Leu Lys Gln Asn Arg Ser Leu Lys Glu Leu Met Phe 
    770                 775                 780                 


Ser Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys Ala Leu Ala Glu Ala 
785                 790                 795                 800 


Leu Lys Val Asn Gln Gly Leu Glu Ser Leu Asp Leu Gln Ser Asn Ser 
                805                 810                 815     


Ile Ser Asp Ala Gly Val Ala Ala Leu Met Gly Ala Leu Cys Thr Asn 
            820                 825                 830         


Gln Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn Ser Ile Ser Pro Glu 
        835                 840                 845             


Gly Ala Gln Ala Ile Ala His Ala Leu Cys Ala Asn Ser Thr Leu Lys 
    850                 855                 860                 


Asn Leu Asp Leu Gln Trp Asn Phe Ile Gln Ala Gly Ala Ala Gln Ala 
865                 870                 875                 880 


Leu Gly Gln Ala Leu Gln Leu Asn Arg Ser Leu Thr Ser Leu Asp Leu 
                885                 890                 895     


Gln Glu Asn Ala Ile Gly Asp Asp Gly Ala Cys Ala Val Ala Arg Ala 
            900                 905                 910         


Leu Lys Val Asn Thr Ala Leu Thr Ala Leu Tyr Leu Gln Val Ala Ser 
        915                 920                 925             


Ile Gly Ala Ser Gly Ala Gln Val Leu Gly Glu Ala Leu Ala Val Asn 
    930                 935                 940                 


Arg Thr Leu Glu Ile Leu Asp Leu Arg Gly Asn Ala Ile Gly Val Ala 
945                 950                 955                 960 


Gly Ala Lys Ala Leu Ala Asn Ala Leu Lys Val Asn Ser Ser Leu Arg 
                965                 970                 975     


Arg Leu Asn Leu Gln Glu Asn Ser Leu Gly Met Asp Gly Ala Ile Cys 
            980                 985                 990         


Ile Ala Thr Ala Leu Ser Gly Asn  His Arg Leu Gln His  Ile Asn Leu 
        995                 1000                 1005             


Gln Gly  Asn His Ile Gly Asp  Ser Gly Ala Arg Met  Ile Ser Glu 
    1010                 1015                 1020             


Ala Ile  Lys Thr Asn Ala Pro  Thr Cys Thr Val Glu  Met 
    1025                 1030                 1035     


<210> 5972
<211> 927
<212> PRT
<213> Homo sapiens

<400> 5972
Met Phe Trp Lys Phe Asp Leu Asn Thr Thr Ser His Val Asp Lys Leu 
1               5                   10                  15      


Leu Asp Lys Glu His Val Thr Leu Gln Glu Leu Met Asp Glu Asp Asp 
            20                  25                  30          


Ile Leu Gln Glu Cys Lys Ala Gln Asn Gln Lys Leu Leu Asp Phe Leu 
        35                  40                  45              


Cys Arg Gln Gln Cys Met Glu Glu Leu Val Ser Leu Ile Thr Gln Asp 
    50                  55                  60                  


Pro Pro Leu Asp Met Glu Glu Lys Val Arg Phe Lys Tyr Pro Asn Thr 
65                  70                  75                  80  


Ala Cys Glu Leu Leu Thr Cys Asp Val Pro Gln Ile Ser Asp Arg Leu 
                85                  90                  95      


Gly Gly Asp Glu Ser Leu Leu Ser Leu Leu Tyr Asp Phe Leu Asp His 
            100                 105                 110         


Glu Pro Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Thr Ile 
        115                 120                 125             


Gly Asn Leu Ile Ala Arg Lys Thr Glu Gln Val Ile Thr Phe Leu Lys 
    130                 135                 140                 


Lys Lys Asp Lys Phe Ile Ser Leu Val Leu Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Leu Met Asp Leu Leu Leu Arg Leu Val Ser Cys Val Glu Pro Ala 
                165                 170                 175     


Gly Leu Arg Gln Asp Val Leu His Trp Leu Asn Glu Glu Lys Val Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Leu Ile His Pro Ser Gln Asp Glu Asp Arg Gln 
        195                 200                 205             


Ser Asn Ala Ser Gln Thr Leu Cys Asp Ile Val Arg Leu Gly Arg Asp 
    210                 215                 220                 


Gln Gly Ser Gln Leu Gln Glu Ala Leu Glu Pro Asp Pro Leu Leu Thr 
225                 230                 235                 240 


Ala Leu Glu Ser Gln Asp Cys Val Glu Gln Leu Leu Lys Asn Met Phe 
                245                 250                 255     


Asp Gly Asp Arg Thr Glu Ser Cys Leu Val Ser Gly Thr Gln Val Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Val Gly Thr Glu Gly Leu Val Asp 
        275                 280                 285             


Ser Phe Ser Gln Gly Leu Glu Arg Ser Tyr Ala Val Ser Ser Ser Val 
    290                 295                 300                 


Leu His Gly Ile Glu Pro Arg Leu Lys Asp Phe His Gln Leu Leu Leu 
305                 310                 315                 320 


Asn Pro Pro Lys Lys Lys Ala Ile Leu Thr Thr Ile Gly Val Leu Glu 
                325                 330                 335     


Glu Pro Leu Gly Asn Ala Arg Leu His Gly Ala Arg Leu Met Ala Ala 
            340                 345                 350         


Leu Leu His Thr Asn Thr Pro Ser Ile Asn Gln Glu Leu Cys Arg Leu 
        355                 360                 365             


Asn Thr Met Asp Leu Leu Leu Asp Leu Phe Phe Lys Tyr Thr Trp Asn 
    370                 375                 380                 


Asn Phe Leu His Phe Gln Val Glu Leu Cys Ile Ala Ala Ile Leu Ser 
385                 390                 395                 400 


His Ala Ala Arg Glu Glu Arg Thr Glu Ala Ser Gly Ser Glu Ser Arg 
                405                 410                 415     


Val Glu Pro Pro His Glu Asn Gly Asn Arg Ser Leu Glu Thr Pro Gln 
            420                 425                 430         


Pro Ala Ala Ser Leu Pro Asp Asn Thr Met Val Thr His Leu Phe Gln 
        435                 440                 445             


Lys Cys Cys Leu Val Gln Arg Ile Leu Glu Ala Trp Glu Ala Asn Asp 
    450                 455                 460                 


His Thr Gln Ala Ala Gly Gly Met Arg Arg Gly Asn Met Gly His Leu 
465                 470                 475                 480 


Thr Arg Ile Ala Asn Ala Val Val Gln Asn Leu Glu Arg Gly Pro Val 
                485                 490                 495     


Gln Thr His Ile Ser Glu Val Ile Arg Gly Leu Pro Ala Asp Cys Arg 
            500                 505                 510         


Gly Arg Trp Glu Ser Phe Val Glu Glu Thr Leu Thr Glu Thr Asn Arg 
        515                 520                 525             


Arg Asn Thr Val Asp Leu Ala Phe Ser Asp Tyr Gln Ile Gln Gln Met 
    530                 535                 540                 


Thr Ala Asn Phe Val Asp Gln Phe Gly Phe Asn Asp Glu Glu Phe Ala 
545                 550                 555                 560 


Asp Gln Asp Asp Asn Ile Asn Ala Pro Phe Asp Arg Ile Ala Glu Ile 
                565                 570                 575     


Asn Phe Asn Ile Asp Ala Asp Glu Asp Ser Pro Ser Ala Ala Leu Phe 
            580                 585                 590         


Glu Ala Cys Cys Ser Asp Arg Ile Gln Pro Phe Asp Asp Asp Glu Asp 
        595                 600                 605             


Glu Asp Ile Trp Glu Asp Ser Asp Thr Arg Cys Ala Ala Arg Val Met 
    610                 615                 620                 


Ala Arg Pro Arg Phe Gly Ala Pro His Ala Ser Glu Ser Cys Ser Lys 
625                 630                 635                 640 


Asn Gly Pro Glu Arg Gly Gly Gln Asp Gly Lys Ala Ser Leu Glu Ala 
                645                 650                 655     


His Arg Asp Ala Pro Gly Ala Gly Ala Pro Pro Ala Pro Gly Lys Lys 
            660                 665                 670         


Glu Ala Pro Pro Val Glu Gly Asp Ser Glu Ala Gly Ala Met Trp Thr 
        675                 680                 685             


Ala Val Phe Asp Glu Pro Ala Asn Ser Thr Pro Thr Ala Pro Gly Val 
    690                 695                 700                 


Val Arg Asp Val Gly Ser Ser Val Trp Ala Ala Gly Thr Ser Ala Pro 
705                 710                 715                 720 


Glu Glu Lys Gly Trp Ala Lys Phe Thr Asp Phe Gln Pro Phe Cys Cys 
                725                 730                 735     


Ser Glu Ser Gly Pro Arg Cys Ser Ser Pro Val Asp Thr Glu Cys Ser 
            740                 745                 750         


His Ala Glu Gly Ser Arg Ser Gln Gly Pro Glu Lys Ala Phe Ser Pro 
        755                 760                 765             


Ala Ser Pro Cys Ala Trp Asn Val Cys Val Thr Arg Lys Ala Pro Leu 
    770                 775                 780                 


Leu Ala Ser Asp Ser Ser Ser Ser Gly Gly Ser His Ser Glu Asp Gly 
785                 790                 795                 800 


Asp Gln Lys Ala Ala Ser Ala Met Asp Ala Val Ser Arg Gly Pro Gly 
                805                 810                 815     


Arg Glu Ala Pro Pro Leu Pro Thr Val Ala Arg Thr Glu Glu Ala Val 
            820                 825                 830         


Gly Arg Val Gly Cys Ala Asp Ser Arg Leu Leu Ser Pro Ala Cys Pro 
        835                 840                 845             


Ala Pro Lys Glu Val Thr Ala Ala Pro Ala Val Ala Val Pro Pro Glu 
    850                 855                 860                 


Ala Thr Val Ala Ile Thr Thr Ala Leu Ser Lys Ala Gly Pro Ala Ile 
865                 870                 875                 880 


Pro Thr Pro Ala Val Ser Ser Ala Leu Ala Val Ala Val Pro Leu Gly 
                885                 890                 895     


Pro Ile Met Ala Val Thr Ala Ala Pro Ala Met Val Ala Thr Leu Gly 
            900                 905                 910         


Thr Val Thr Lys Asp Gly Gln Met Pro Arg Gln Lys Glu Leu Pro 
        915                 920                 925         


<210> 5973
<211> 739
<212> PRT
<213> Homo sapiens

<400> 5973
Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg 
1               5                   10                  15      


Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe 
            20                  25                  30          


Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys 
        35                  40                  45              


Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln 
    50                  55                  60                  


Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys Glu Val His Gln Thr 
65                  70                  75                  80  


Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln 
                85                  90                  95      


Gln His Val Gln Leu Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn 
            100                 105                 110         


Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu 
        115                 120                 125             


Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn 
    130                 135                 140                 


Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met 
145                 150                 155                 160 


Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro 
                165                 170                 175     


His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys 
            180                 185                 190         


Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu 
        195                 200                 205             


Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile 
    210                 215                 220                 


Leu Phe Thr Lys Ala Glu Asp Asn Leu Leu Ala Leu Gly Leu Lys His 
225                 230                 235                 240 


Phe Glu Gly Thr Glu Phe Leu Asn Pro Leu Ile Ser Lys Tyr Leu Leu 
                245                 250                 255     


Thr Cys Lys Thr Ala Arg Gln Leu Thr Val Arg Ile Lys Asn Leu Asn 
            260                 265                 270         


Met Asn Arg Ala Pro Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr Lys 
        275                 280                 285             


Gln Leu Pro Val Leu Gly Lys Cys Cys Glu Glu Ile Gln Pro His Gln 
    290                 295                 300                 


Trp Lys Pro Pro Ile Glu Arg Glu Glu His Arg Leu Pro Phe Trp Leu 
305                 310                 315                 320 


Lys Ala Ser Leu Pro Ser Ile Gln Glu Glu Leu Arg His Met Ala Asp 
                325                 330                 335     


Gly Ala Arg Glu Val Gly Asn Met Thr Gly Thr Thr Glu Ile Asn Ser 
            340                 345                 350         


Asp Gln Gly Leu Glu Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr Arg 
        355                 360                 365             


Tyr Pro Leu Leu Leu Pro Lys Gly Val Val Leu Lys Leu Lys Pro Val 
    370                 375                 380                 


Ala Asp Arg Phe Pro Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser Val 
385                 390                 395                 400 


Leu Lys Pro Leu Leu Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser Phe 
                405                 410                 415     


Asn Pro Gly Lys Thr Pro Ala Gln Ser Thr His Ser Glu Ala Pro Pro 
            420                 425                 430         


Ser Lys Met Val Leu Arg Ile Pro His Pro Ile Gln Pro Ala Thr Val 
        435                 440                 445             


Leu Gln Thr Val Pro Gly Val Pro Pro Leu Gly Val Ser Gly Gly Glu 
    450                 455                 460                 


Ser Phe Glu Ser Pro Ala Ala Leu Pro Ala Met Pro Pro Glu Ala Arg 
465                 470                 475                 480 


Thr Ser Phe Pro Leu Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala Pro 
                485                 490                 495     


Val Pro Lys Val Met Met Pro Ser Pro Ala Ser Ser Met Phe Arg Lys 
            500                 505                 510         


Pro Tyr Val Arg Arg Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala Phe 
        515                 520                 525             


Arg Cys Ile Lys Pro Ala Pro Val Ile His Pro Ala Ser Val Ile Phe 
    530                 535                 540                 


Thr Val Pro Ala Thr Thr Val Lys Ile Val Ser Leu Gly Gly Gly Cys 
545                 550                 555                 560 


Asn Met Ile Gln Pro Val Asn Ala Ala Val Ala Gln Ser Pro Gln Thr 
                565                 570                 575     


Ile Pro Ile Ala Thr Leu Leu Val Asn Pro Thr Ser Phe Pro Cys Pro 
            580                 585                 590         


Leu Asn Gln Pro Leu Val Ala Ser Ser Val Ser Pro Leu Ile Val Ser 
        595                 600                 605             


Gly Asn Ser Val Asn Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys Ala 
    610                 615                 620                 


His Met Asn Val Asp Ile Ala Cys Ala Val Ala Asp Gly Glu Asn Ala 
625                 630                 635                 640 


Phe Gln Gly Leu Glu Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro Leu 
                645                 650                 655     


Ser Ala Thr Val Phe Pro Lys Val Glu His Ser Pro Gly Pro Pro Pro 
            660                 665                 670         


Val Asp Lys Gln Cys Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr Arg 
        675                 680                 685             


Trp Thr Val Val Lys Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro Leu 
    690                 695                 700                 


Pro Gln Gly Ile Gln Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp Leu 
705                 710                 715                 720 


Glu Glu Val Val Lys Met Glu Pro Glu Asp Ala Thr Glu Glu Ile Ser 
                725                 730                 735     


Gly Phe Leu 
            


<210> 5974
<211> 636
<212> PRT
<213> Homo sapiens

<400> 5974
Met Glu Lys Ala Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys 
1               5                   10                  15      


His Leu Lys Thr Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser 
            20                  25                  30          


Glu Ser His Leu Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr 
        35                  40                  45              


Glu Leu Glu Ala Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val 
    50                  55                  60                  


Glu Leu Leu Leu Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe 
65                  70                  75                  80  


Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ile Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Glu His Leu Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn 
        115                 120                 125             


Leu Ser Ser Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn 
    130                 135                 140                 


Thr Asn Leu Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn 
                165                 170                 175     


Arg Phe Ser Gln Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln 
            180                 185                 190         


Ile His Lys Arg Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys 
        195                 200                 205             


Ser Leu Glu Thr Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn 
    210                 215                 220                 


Lys Asn Glu Ala Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val 
225                 230                 235                 240 


Ala Leu Lys Lys Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe 
                245                 250                 255     


Thr Gly Ala Ile Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala 
            260                 265                 270         


Lys Leu Ser Glu Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr 
        275                 280                 285             


Glu Lys Ile Val Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr 
    290                 295                 300                 


Met Lys Lys Gln Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu 
305                 310                 315                 320 


Asp His Gly Lys Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser 
                325                 330                 335     


Ile Glu Tyr Glu Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys 
            340                 345                 350         


Leu Arg Phe Pro Cys Arg Ile Thr Glu Ser Lys Asn Met Asn Ile Leu 
        355                 360                 365             


Ile Val Leu Asp Met Leu Cys Tyr Ile Ser Ser Glu Lys Thr Thr Leu 
    370                 375                 380                 


Ala Ala Leu Lys Asp Glu Val Val Ser Val Glu Asn Glu Leu Ser Glu 
385                 390                 395                 400 


Leu Gln Glu Val Glu Lys Lys Gln Lys Thr Leu Ile Glu Met Tyr Lys 
                405                 410                 415     


Thr Gln Val Gln Lys Leu Gln Glu Ala Ala Glu Ile Val Lys Ser Arg 
            420                 425                 430         


Cys Glu Asn Leu Leu His Lys Asn Asn Gln Ile Thr Lys Thr Lys Asn 
        435                 440                 445             


Lys Asn Val Glu Lys Met Arg Gly Gln Met Glu Ser His Leu Lys Glu 
    450                 455                 460                 


Leu Glu Arg Val Cys Asp Ser Leu Thr Ala Ala Glu Arg Arg Leu His 
465                 470                 475                 480 


Glu Cys Gln Glu Ser Leu Gln Cys Cys Lys Gly Lys Cys Ala Asp Gln 
                485                 490                 495     


Glu His Thr Ile Arg Glu Leu Gln Gly Gln Val Asp Gly Asn His Asn 
            500                 505                 510         


Leu Leu Thr Lys Leu Ser Leu Glu Glu Glu Asn Cys Leu Ile Gln Leu 
        515                 520                 525             


Lys Cys Glu Asn Leu Gln Gln Lys Leu Glu Gln Met Asp Ala Glu Asn 
    530                 535                 540                 


Lys Glu Leu Glu Lys Lys Leu Ala Asn Gln Glu Glu Cys Leu Lys His 
545                 550                 555                 560 


Ser Asn Leu Lys Phe Lys Glu Lys Ser Ala Glu Tyr Thr Ala Leu Ala 
                565                 570                 575     


Arg Gln Leu Glu Ala Ala Leu Glu Glu Gly Arg Gln Lys Val Ala Glu 
            580                 585                 590         


Glu Ile Glu Lys Met Ser Ser Arg Glu Ser Ala Leu Gln Ile Lys Ile 
        595                 600                 605             


Leu Asp Leu Glu Thr Glu Leu Arg Lys Lys Asn Glu Glu Gln Asn Gln 
    610                 615                 620                 


Leu Val Cys Lys Met Asn Ser Asp Pro Glu Thr Pro 
625                 630                 635     


<210> 5975
<211> 290
<212> PRT
<213> Homo sapiens

<400> 5975
Met Ala Ala Val Glu Lys Arg Arg Gln Ala Val Pro Pro Pro Ala Gly 
1               5                   10                  15      


Phe Thr Asp Ser Gly Arg Gln Ser Val Ser Arg Ala Ala Gly Ala Ala 
            20                  25                  30          


Glu Ser Glu Glu Asp Phe Leu Arg Gln Val Gly Val Thr Glu Met Leu 
        35                  40                  45              


Arg Ala Ala Leu Leu Lys Val Leu Glu Ala Arg Pro Glu Glu Pro Ile 
    50                  55                  60                  


Ala Phe Leu Ala His Tyr Phe Glu Asn Met Gly Leu Arg Ser Pro Val 
65                  70                  75                  80  


Asn Gly Gly Ala Gly Glu Pro Pro Gly Gln Leu Leu Leu Gln Gln Gln 
                85                  90                  95      


Arg Leu Gly Arg Ala Leu Trp His Leu Arg Leu Ala His His Ser Gln 
            100                 105                 110         


Arg Ala Ala Phe Asn Asn Asn Val Ser Val Ala Tyr Glu Cys Leu Ser 
        115                 120                 125             


Ala Gly Gly Arg Arg Lys Arg Pro Gly Leu Asp Gly Arg Thr Tyr Ser 
    130                 135                 140                 


Glu Leu Leu Arg Arg Ile Cys Arg Asp Gly Gln Ala Pro Glu Glu Val 
145                 150                 155                 160 


Val Ala Pro Leu Leu Arg Lys Val Gln Cys Arg Asp His Glu Ala Val 
                165                 170                 175     


Pro Leu Ser Val Phe Arg Ala Gly Thr Leu Thr Cys Phe Val Leu Leu 
            180                 185                 190         


Glu Phe Val Ala Arg Ala Gly Ala Leu Phe Gln Leu Leu Glu Asp Ser 
        195                 200                 205             


Ala Ala Ala Val Ala Asp Arg Arg Val Gly Gln Ala Val Leu Asp Thr 
    210                 215                 220                 


Leu Glu Gly Ala Leu Gln Ala Ser Asp Ala Ala Ala Pro Ala Arg Phe 
225                 230                 235                 240 


Leu Glu Ala Gly Ser Arg Leu Gly Pro Asp Ser Leu Ala Leu Ala Leu 
                245                 250                 255     


Asp Arg Ala Val Gly Gly Arg Arg Pro Ser Ala Pro Met Thr Arg Glu 
            260                 265                 270         


Glu Phe Leu Glu Arg Ala Ala Ala Leu Phe Ile Ala Lys Val Lys Pro 
        275                 280                 285             


Val Gly 
    290 


<210> 5976
<211> 406
<212> PRT
<213> Homo sapiens

<400> 5976
Met Ala Asp Ser Gln Leu Phe Cys Val Ala Glu Glu Arg Ser Gly His 
1               5                   10                  15      


Cys Ala Val Val Asp Gly Asn Phe Leu Tyr Val Trp Gly Gly Tyr Val 
            20                  25                  30          


Ser Ile Glu Asp Asn Glu Val Tyr Leu Pro Asn Asp Glu Ile Trp Thr 
        35                  40                  45              


Tyr Asp Ile Asp Ser Gly Leu Trp Arg Met His Leu Met Glu Gly Glu 
    50                  55                  60                  


Leu Pro Ala Ser Met Ser Gly Ser Cys Gly Ala Cys Ile Asn Gly Lys 
65                  70                  75                  80  


Leu Tyr Ile Phe Gly Gly Tyr Asp Asp Lys Gly Tyr Ser Asn Arg Leu 
                85                  90                  95      


Tyr Phe Val Asn Leu Arg Thr Arg Asp Glu Thr Tyr Ile Trp Glu Lys 
            100                 105                 110         


Ile Thr Asp Phe Glu Gly Gln Pro Pro Thr Pro Arg Asp Lys Leu Ser 
        115                 120                 125             


Cys Trp Val Tyr Lys Asp Arg Leu Ile Tyr Phe Gly Gly Tyr Gly Cys 
    130                 135                 140                 


Arg Arg His Ser Glu Leu Gln Asp Cys Phe Asp Val His Asp Ala Ser 
145                 150                 155                 160 


Trp Glu Glu Gln Ile Phe Trp Gly Trp His Asn Asp Val His Ile Phe 
                165                 170                 175     


Asp Thr Lys Thr Gln Thr Trp Phe Gln Pro Glu Ile Lys Gly Gly Val 
            180                 185                 190         


Pro Pro Gln Pro Arg Ala Ala His Thr Cys Ala Val Leu Gly Asn Lys 
        195                 200                 205             


Gly Tyr Ile Phe Gly Gly Arg Val Leu Gln Thr Arg Met Asn Asp Leu 
    210                 215                 220                 


His Tyr Leu Asn Leu Asp Thr Trp Thr Trp Ser Gly Arg Ile Thr Ile 
225                 230                 235                 240 


Asn Gly Glu Ser Pro Lys His Arg Ser Trp His Thr Leu Thr Pro Ile 
                245                 250                 255     


Ala Asp Asp Lys Leu Phe Leu Cys Gly Gly Leu Ser Ala Asp Asn Ile 
            260                 265                 270         


Pro Leu Ser Asp Gly Trp Ile His Asn Val Thr Thr Asn Cys Trp Lys 
        275                 280                 285             


Gln Leu Thr His Leu Pro Lys Thr Arg Pro Arg Leu Trp His Thr Ala 
    290                 295                 300                 


Cys Leu Gly Lys Glu Asn Glu Ile Met Val Phe Gly Gly Ser Lys Asp 
305                 310                 315                 320 


Asp Leu Leu Ala Leu Asp Thr Gly His Cys Asn Asp Leu Leu Ile Phe 
                325                 330                 335     


Gln Thr Gln Pro Tyr Ser Leu Leu Arg Ser Cys Leu Asp Cys Ile Gly 
            340                 345                 350         


Lys Asn Ser Ile Met Leu Glu Ser Gln Ile Ser Leu Leu Pro Pro Lys 
        355                 360                 365             


Leu Leu Gln Gln Val Leu Lys Lys Ile Thr Phe Trp Ala Ala Ala Asn 
    370                 375                 380                 


His Arg Glu Glu Gln Arg Val Gln Lys Glu Glu Thr Glu Asn Lys Tyr 
385                 390                 395                 400 


Gln Trp Ile Ser Ser Asn 
                405     


<210> 5977
<211> 370
<212> PRT
<213> Homo sapiens

<400> 5977
Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro Pro Pro Gln Asn 
1               5                   10                  15      


Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln Asp Tyr Ala Gly 
            20                  25                  30          


Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser Thr Gln Ala His 
        35                  40                  45              


Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn Gly Ser Leu Thr 
    50                  55                  60                  


Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser Gln Thr Gln Ser 
65                  70                  75                  80  


Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg Leu His Val Ser 
                85                  90                  95      


Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly 
            100                 105                 110         


Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly 
        115                 120                 125             


Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp 
    130                 135                 140                 


Arg Ala Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile 
145                 150                 155                 160 


Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Met Val 
                165                 170                 175     


Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro Val Val Gly Ala Val 
            180                 185                 190         


Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe Gln Ala Asp Val Ser 
        195                 200                 205             


Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly Arg Gly Gly Ile Asn 
    210                 215                 220                 


Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro Tyr Pro Thr Ala Ala 
225                 230                 235                 240 


Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu Arg Gly Arg Gly Arg 
                245                 250                 255     


Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro Thr Ala Ile Pro Ala 
            260                 265                 270         


Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr Gly Ala Asp Leu Tyr 
        275                 280                 285             


Ile Glu Ser Ala Asn Cys Phe Arg Ser Asn Arg Val Asp Met Gln Pro 
    290                 295                 300                 


Thr Asp Met His Ser Leu Leu Leu Gln Pro Gln Pro Pro Leu Leu Gln 
305                 310                 315                 320 


Pro Leu Gln Pro Leu Thr Val Thr Val Met Ala Gly Cys Thr Gln Pro 
                325                 330                 335     


Thr Pro Thr Met Pro Leu Pro Leu Pro Leu Ala Met Glu Leu Ala Leu 
            340                 345                 350         


Trp Arg Val Tyr Thr Glu Val Ala Thr Ala Asp Leu Pro Pro Thr Glu 
        355                 360                 365             


Val Thr 
    370 


<210> 5978
<211> 177
<212> PRT
<213> Homo sapiens

<400> 5978
Met Ser Glu Asp Ser Glu Lys Glu Asp Tyr Ser Asp Arg Thr Ile Ser 
1               5                   10                  15      


Asp Glu Asp Glu Ser Asp Glu Asp Met Phe Met Lys Phe Val Ser Glu 
            20                  25                  30          


Asp Leu His Arg Cys Ala Leu Leu Thr Ala Asp Ser Phe Gly Asp Pro 
        35                  40                  45              


Phe Phe Pro Arg Thr Thr Gln Ile Leu Leu Glu Tyr Gln Leu Gly Arg 
    50                  55                  60                  


Trp Val Pro Arg Leu Arg Glu Pro Arg Asp Leu Tyr Gly Val Ser Ser 
65                  70                  75                  80  


Ser Gly Pro Leu Ser Pro Thr Arg Trp Pro Tyr His Cys Glu Val Ile 
                85                  90                  95      


Asp Glu Lys Val Gln His Ile Asp Gly Val Ser Cys Trp Ser Glu Ser 
            100                 105                 110         


His Gln Ala Gly Ala Gln Trp Cys Asp Leu Gly Ser Leu Gln Pro Pro 
        115                 120                 125             


Pro Pro Arg Phe Lys Arg Phe Ala Cys Phe Ser Leu Leu Ser Ser Arg 
    130                 135                 140                 


Asp Tyr Arg Arg Val Pro Pro Arg Ser Ala Asn Phe Val Phe Leu Val 
145                 150                 155                 160 


Glu Thr Gly Phe His His Val Gly Gln Asp Gly Leu Arg Leu Leu Thr 
                165                 170                 175     


Ser 
    


<210> 5979
<211> 608
<212> PRT
<213> Homo sapiens

<400> 5979
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Arg Arg Leu His Lys Leu Gly 
            100                 105                 110         


Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu Val Val Ser 
        115                 120                 125             


Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln Ser Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val Gly Gln Asp Ser 
145                 150                 155                 160 


Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys Glu Ala Pro Pro 
                165                 170                 175     


Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu 
            180                 185                 190         


Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu Arg Ala Leu 
        195                 200                 205             


Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg Glu Leu Glu 
    210                 215                 220                 


Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser Phe Asn Arg 
225                 230                 235                 240 


Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val Thr Cys Met 
                245                 250                 255     


Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser Tyr Asn Asn 
            260                 265                 270         


Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn 
        275                 280                 285             


Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser 
    290                 295                 300                 


Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn Leu Val Val 
305                 310                 315                 320 


Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser His 
                325                 330                 335     


Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr 
            340                 345                 350         


His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn 
        355                 360                 365             


Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp Ser Leu Asp 
    370                 375                 380                 


Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr Asn Lys Ser 
385                 390                 395                 400 


Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly Asp Val Asn 
                405                 410                 415     


Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr Ala Cys Arg 
            420                 425                 430         


His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly His Gln Gly 
        435                 440                 445             


Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro Ile Asp Phe 
    450                 455                 460                 


Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp 
465                 470                 475                 480 


Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp 
                485                 490                 495     


Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala Leu Phe Ala 
            500                 505                 510         


Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp 
        515                 520                 525             


Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala Ser Ala Leu 
    530                 535                 540                 


Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val Ala Val Gly Asp 
545                 550                 555                 560 


Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu Leu Ala Val Pro 
                565                 570                 575     


His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu Val Glu Ile Arg 
            580                 585                 590         


Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val Glu Leu Ser Ala 
        595                 600                 605             


<210> 5980
<211> 208
<212> PRT
<213> Homo sapiens

<400> 5980
Met Glu Gly Ala Ala Ala Pro Val Ala Gly Asp Arg Pro Asp Leu Gly 
1               5                   10                  15      


Leu Gly Ala Pro Gly Ser Pro Arg Glu Ala Val Ala Gly Ala Thr Ala 
            20                  25                  30          


Ala Leu Glu Pro Arg Lys Pro His Gly Val Lys Arg His His His Lys 
        35                  40                  45              


His Asn Leu Lys His Arg Tyr Glu Leu Gln Glu Thr Leu Gly Lys Gly 
    50                  55                  60                  


Thr Tyr Gly Lys Val Lys Arg Ala Thr Glu Arg Phe Ser Gly Arg Val 
65                  70                  75                  80  


Val Ala Ile Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu Gln Asp 
                85                  90                  95      


Met Val His Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu Asn His 
            100                 105                 110         


Pro His Ile Ile Ser Ile Tyr Glu Val Phe Glu Asn Lys Asp Lys Ile 
        115                 120                 125             


Val Ile Ile Met Glu Tyr Ala Ser Lys Gly Glu Leu Tyr Asp Tyr Ile 
    130                 135                 140                 


Ser Glu Arg Arg Arg Leu Ser Glu Arg Glu Thr Arg His Phe Phe Arg 
145                 150                 155                 160 


Gln Ile Val Ser Ala Val His Tyr Cys His Lys Asn Gly Val Val His 
                165                 170                 175     


Arg Asp Leu Lys Leu Lys Arg Pro Ser Arg Glu Asn Gln Val Thr Thr 
            180                 185                 190         


Leu Pro Gln Ser Ala Val Ser Leu Arg Ser Cys Trp Thr Val Met Met 
        195                 200                 205             


<210> 5981
<211> 329
<212> PRT
<213> Homo sapiens

<400> 5981
Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu 
            20                  25                  30          


Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser Arg 
        35                  40                  45              


Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn 
    50                  55                  60                  


Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala Pro 
65                  70                  75                  80  


Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val Ile 
                85                  90                  95      


Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser 
            100                 105                 110         


Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys Met Ile 
        115                 120                 125             


Glu Met Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His Glu Phe 
    130                 135                 140                 


Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu Thr 
145                 150                 155                 160 


Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr Ala 
                165                 170                 175     


Ser Cys Ser Thr Phe Asn Leu Glu Gly Leu Phe Ser Leu Ile Gln Gln 
            180                 185                 190         


Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro Pro Pro 
        195                 200                 205             


Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys Gln Pro 
    210                 215                 220                 


Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys Pro Tyr 
225                 230                 235                 240 


Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu Lys Glu 
                245                 250                 255     


Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu Asp 
            260                 265                 270         


Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro Ala 
        275                 280                 285             


Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu Gln 
    290                 295                 300                 


Arg Pro Cys Gln Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu Asp 
305                 310                 315                 320 


Glu Ala Ile Glu Val Glu Ala Thr Val 
                325                 


<210> 5982
<211> 294
<212> PRT
<213> Homo sapiens

<400> 5982
Met Ser Gln Pro Ala Gly Gly Arg Arg Lys Pro Arg Thr Leu Gly Pro 
1               5                   10                  15      


Pro Val Cys Ser Ile Arg Pro Phe Lys Ser Ser Glu Gln Tyr Leu Glu 
            20                  25                  30          


Ala Met Lys Glu Asp Leu Ala Glu Trp Leu Arg Asp Leu Tyr Gly Leu 
        35                  40                  45              


Asp Ile Asp Ala Ala Asn Phe Leu Gln Val Leu Glu Thr Gly Leu Val 
    50                  55                  60                  


Leu Cys Gln His Ala Asn Val Val Thr Asp Ala Ala Leu Ala Phe Leu 
65                  70                  75                  80  


Ala Glu Ala Pro Ala Gln Ala Gln Lys Ile Pro Met Pro Arg Val Gly 
                85                  90                  95      


Val Ser Cys Asn Gly Ala Ala Gln Pro Gly Thr Phe Gln Ala Arg Asp 
            100                 105                 110         


Asn Val Ser Asn Phe Ile Gln Trp Cys Arg Lys Glu Met Gly Ile Gln 
        115                 120                 125             


Glu Val Leu Met Phe Glu Thr Glu Asp Leu Val Leu Arg Lys Asn Val 
    130                 135                 140                 


Lys Asn Val Val Leu Cys Leu Leu Glu Leu Gly Arg Arg Ala Trp Arg 
145                 150                 155                 160 


Phe Gly Val Ala Ala Pro Thr Leu Val Gln Leu Glu Glu Glu Ile Glu 
                165                 170                 175     


Glu Glu Val Arg Arg Glu Leu Ala Leu Pro Pro Leu Pro Gln Pro Gly 
            180                 185                 190         


Pro Asp Gly Ala Glu Pro Cys Glu Pro Leu His Val Pro Ser Ala Val 
        195                 200                 205             


Leu His Gly Gln Ser Val Tyr Val Phe Leu Gly Pro Ala Arg Gln Pro 
    210                 215                 220                 


Pro Lys Asp Arg Leu Leu Arg Ala Val Leu Gly Ser Lys Gly Gly Glu 
225                 230                 235                 240 


Ala Ser Arg Val Asp Gly Ala Ser Val Gly Glu Glu Glu Glu Glu Gly 
                245                 250                 255     


Lys Glu Glu Lys Glu Pro Ala Ala Pro Leu Glu Ser Ser Pro Gln Pro 
            260                 265                 270         


Pro Glu Gly Leu Gln Pro His Trp Leu Asn Gln Ala Pro Leu Pro Pro 
        275                 280                 285             


Glu Glu Glu Ser Trp Val 
    290                 


<210> 5983
<211> 517
<212> PRT
<213> Homo sapiens

<400> 5983
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Ser Ser Ser Arg Leu Ser Tyr Gln 
            260                 265                 270         


Pro Ala Ala Leu Gly Val Gly Ser Ala Asp Leu Ala Tyr Pro Val Val 
        275                 280                 285             


Phe Ala Ala Gly Leu Asn Ala Thr His Pro His Gln Leu Met Val Pro 
    290                 295                 300                 


Gly Lys Glu Gly Gly Val Pro Leu Ala Pro Asn Gln Pro Val His Gly 
305                 310                 315                 320 


Thr Gln Ala Asp Gln Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg 
                325                 330                 335     


Thr His Cys Ala Ala Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val 
            340                 345                 350         


Ser Asn Ser Ser Glu Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr 
        355                 360                 365             


Ile Phe Val Arg Lys Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln 
    370                 375                 380                 


Val Thr Leu Thr Ser Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys 
385                 390                 395                 400 


Asn Leu Glu Leu Glu Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser 
                405                 410                 415     


Pro Glu Thr Glu Ser Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser 
            420                 425                 430         


Ser Gly Gly Ser Ser Gly Asn Thr His Asp Asp Phe Val Met Ile Asp 
        435                 440                 445             


Phe Lys Pro Ala Phe Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly 
    450                 455                 460                 


Thr Phe Tyr Arg Glu Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser 
465                 470                 475                 480 


Ile Asp Ile Gly Ala Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro 
                485                 490                 495     


Glu Lys Leu Ala Val His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe 
            500                 505                 510         


Val Glu Thr Leu Gln 
        515         


<210> 5984
<211> 316
<212> PRT
<213> Homo sapiens

<400> 5984
Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Leu Gly Lys Val Lys Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 
        35                  40                  45              


Tyr Gln Asn Glu His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 
    50                  55                  60                  


Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Pro Thr Phe Phe Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr 
                85                  90                  95      


Leu Lys Asp Leu Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Phe Lys Ser Gly Asp Asp Leu Phe Pro Lys Asp Asp Lys 
        115                 120                 125             


Gly Asn Ala Ile Gly Gly Lys Ala Thr Phe Leu Asp Ala Trp Glu Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Ser His Phe Gln Ile Glu Lys Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 
                245                 250                 255     


Asn Val Ile Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Val Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Asn Val Leu Gln Ser 
    290                 295                 300                 


Ser His Leu Glu Asp Tyr Pro Phe Asn Ala Glu Tyr 
305                 310                 315     


<210> 5985
<211> 2757
<212> PRT
<213> Homo sapiens

<400> 5985
Glu Pro Lys Val Val Phe Ala Lys Glu Gln Pro Val His Arg Glu Val 
1               5                   10                  15      


Gln Ala Gln Ala Gly Ala Ser Thr Thr Leu Ser Cys Glu Val Ala Gln 
            20                  25                  30          


Ala Gln Thr Glu Val Met Trp Tyr Lys Asp Gly Lys Lys Leu Ser Phe 
        35                  40                  45              


Ser Ser Lys Val Arg Met Glu Ala Val Gly Cys Thr Arg Arg Leu Val 
    50                  55                  60                  


Val Gln Gln Ala Gly Gln Ala Val Ala Gly Glu Tyr Ser Cys Glu Ala 
65                  70                  75                  80  


Gly Ser Gln Arg Leu Ser Phe His Leu His Val Ala Glu Pro Lys Ala 
                85                  90                  95      


Val Phe Ala Lys Glu Gln Pro Ala His Arg Glu Val Gln Ala Glu Ala 
            100                 105                 110         


Gly Ala Ser Ala Thr Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu 
        115                 120                 125             


Val Thr Trp Tyr Lys Asp Gly Lys Lys Leu Ser Ser Ser Leu Lys Val 
    130                 135                 140                 


His Val Glu Ala Ala Gly Cys Thr Arg Arg Leu Val Val Gln Gln Ala 
145                 150                 155                 160 


Gly Gln Ala Asp Thr Gly Glu Tyr Ser Cys Glu Ala Gly Gly Gln Gln 
                165                 170                 175     


Leu Ser Phe Arg Leu Gln Val Ala Glu Pro Lys Ala Val Phe Ala Lys 
            180                 185                 190         


Glu Gln Pro Ala Ser Arg Glu Val Gln Ala Glu Ala Gly Thr Ser Ala 
        195                 200                 205             


Thr Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr 
    210                 215                 220                 


Lys Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Val Arg Met Glu Ala 
225                 230                 235                 240 


Val Gly Cys Thr Arg Arg Leu Val Val Gln Glu Ala Gly Gln Ala Asp 
                245                 250                 255     


Ala Gly Glu Tyr Ser Cys Lys Ala Gly Asp Gln Arg Leu Ser Phe His 
            260                 265                 270         


Leu His Val Ala Glu Pro Lys Val Val Phe Ala Lys Glu Gln Pro Ala 
        275                 280                 285             


His Arg Glu Val Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys 
    290                 295                 300                 


Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys 
305                 310                 315                 320 


Lys Leu Ser Ser Ser Ser Lys Val Arg Val Glu Ala Val Gly Cys Thr 
                325                 330                 335     


Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Glu Ala Gly Glu Tyr 
            340                 345                 350         


Ser Cys Glu Ala Gly Gly Gln Gln Leu Ser Phe Arg Leu Gln Val Ala 
        355                 360                 365             


Glu Pro Lys Ala Val Phe Ala Lys Glu Gln Val Val Phe Ala Lys Asp 
    370                 375                 380                 


Gln Pro Val His Arg Glu Val Gln Ala Glu Ala Gly Thr Ser Thr Met 
385                 390                 395                 400 


Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu Val Met Trp Tyr Lys 
                405                 410                 415     


Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Met Arg Val Glu Ala Val 
            420                 425                 430         


Gly Cys Thr Arg Arg Leu Val Val Gln Glu Ala Gly Gln Ala Asp Ala 
        435                 440                 445             


Gly Glu Tyr Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu 
    450                 455                 460                 


His Val Ala Glu Pro Lys Val Val Phe Ala Lys Glu Gln Pro Ala Cys 
465                 470                 475                 480 


Arg Glu Val Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys Glu 
                485                 490                 495     


Val Ala Gln Gly Gln Met Glu Val Thr Trp Tyr Lys Asp Gly Lys Lys 
            500                 505                 510         


Leu Ser Ser Ser Ser Lys Val His Met Glu Ala Ser Gly Tyr Thr Arg 
        515                 520                 525             


Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr Ser 
    530                 535                 540                 


Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe Arg Leu His Val Ala Glu 
545                 550                 555                 560 


Leu Glu Pro Gln Ile Ser Glu Arg Pro Cys Arg Arg Glu Pro Leu Val 
                565                 570                 575     


Val Lys Glu His Glu Asp Ile Ile Leu Thr Ala Thr Leu Ala Thr Pro 
            580                 585                 590         


Ser Ala Ala Thr Val Thr Trp Leu Lys Asp Gly Val Glu Ile Arg Arg 
        595                 600                 605             


Ser Lys Arg His Glu Thr Ala Ser Gln Gly Asp Thr His Thr Leu Thr 
    610                 615                 620                 


Val His Gly Ala Gln Val Leu Asp Ser Ala Ile Tyr Ser Cys Arg Val 
625                 630                 635                 640 


Gly Ala Glu Gly Gln Asp Phe Pro Val Gln Val Glu Glu Val Ala Ala 
                645                 650                 655     


Lys Phe Cys Arg Leu Leu Glu Pro Val Cys Gly Glu Leu Gly Gly Thr 
            660                 665                 670         


Val Thr Leu Ala Cys Glu Leu Ser Pro Ala Cys Ala Glu Val Val Trp 
        675                 680                 685             


Arg Cys Gly Asn Thr Gln Leu Arg Val Gly Lys Arg Phe Gln Met Val 
    690                 695                 700                 


Ala Glu Gly Pro Val Arg Ser Leu Thr Val Leu Gly Leu Arg Ala Glu 
705                 710                 715                 720 


Asp Ala Gly Glu Tyr Val Cys Glu Ser Arg Asp Asp His Thr Ser Ala 
                725                 730                 735     


Gln Leu Thr Val Ser Val Pro Arg Val Val Lys Phe Met Ser Gly Leu 
            740                 745                 750         


Ser Thr Val Val Ala Glu Glu Gly Gly Glu Ala Thr Phe Gln Cys Val 
        755                 760                 765             


Val Ser Pro Ser Asp Val Ala Val Val Trp Phe Arg Asp Gly Ala Leu 
    770                 775                 780                 


Leu Gln Pro Ser Glu Lys Phe Ala Ile Ser Gln Ser Gly Ala Ser His 
785                 790                 795                 800 


Ser Leu Thr Ile Ser Asp Leu Val Leu Glu Asp Ala Gly Gln Ile Thr 
                805                 810                 815     


Val Glu Ala Glu Gly Ala Ser Ser Ser Ala Ala Leu Arg Val Arg Glu 
            820                 825                 830         


Ala Pro Val Leu Phe Lys Lys Lys Leu Glu Pro Gln Thr Val Glu Glu 
        835                 840                 845             


Arg Ser Ser Val Thr Leu Glu Val Glu Leu Thr Arg Pro Trp Pro Glu 
    850                 855                 860                 


Leu Arg Trp Thr Arg Asn Ala Thr Ala Leu Ala Pro Gly Lys Asn Val 
865                 870                 875                 880 


Glu Ile His Ala Glu Gly Ala Arg His Arg Leu Val Leu His Asn Val 
                885                 890                 895     


Gly Phe Ala Asp Arg Gly Phe Phe Gly Cys Glu Thr Pro Asp Asp Lys 
            900                 905                 910         


Thr Gln Ala Lys Leu Thr Val Glu Met Arg Gln Val Arg Leu Val Arg 
        915                 920                 925             


Gly Leu Gln Ala Val Glu Ala Arg Glu Gln Gly Thr Ala Thr Met Glu 
    930                 935                 940                 


Val Gln Leu Ser His Ala Asp Val Asp Gly Ser Trp Thr Arg Asp Gly 
945                 950                 955                 960 


Leu Arg Phe Gln Gln Gly Pro Thr Cys His Leu Ala Val Arg Gly Pro 
                965                 970                 975     


Met His Thr Leu Thr Leu Ser Gly Leu Arg Pro Glu Asp Ser Gly Leu 
            980                 985                 990         


Met Val Phe Lys Ala Glu Gly Val  His Thr Ser Ala Arg  Leu Val Val 
        995                 1000                 1005             


Thr Glu  Leu Pro Val Ser Phe  Ser Arg Pro Leu Gln  Asp Val Val 
    1010                 1015                 1020             


Thr Thr  Glu Lys Glu Lys Val  Thr Leu Glu Cys Glu  Leu Ser Arg 
    1025                 1030                 1035             


Pro Asn  Val Asp Val Arg Trp  Leu Lys Asp Gly Val  Glu Leu Arg 
    1040                 1045                 1050             


Ala Gly  Lys Thr Met Ala Ile  Ala Ala Gln Gly Ala  Cys Arg Ser 
    1055                 1060                 1065             


Leu Thr  Ile Tyr Arg Cys Glu  Phe Ala Asp Gln Gly  Val Tyr Val 
    1070                 1075                 1080             


Cys Asp  Ala His Asp Ala Gln  Ser Ser Ala Ser Val  Lys Val Gln 
    1085                 1090                 1095             


Gly Arg  Thr Tyr Thr Leu Ile  Tyr Arg Arg Val Leu  Ala Glu Asp 
    1100                 1105                 1110             


Ala Gly  Glu Ile Gln Phe Val  Ala Glu Asn Ala Glu  Ser Arg Ala 
    1115                 1120                 1125             


Gln Leu  Arg Val Lys Glu Leu  Pro Val Thr Leu Val  Arg Pro Leu 
    1130                 1135                 1140             


Arg Asp  Lys Ile Ala Met Glu  Lys His Arg Gly Val  Leu Glu Cys 
    1145                 1150                 1155             


Gln Val  Ser Arg Ala Ser Ala  Gln Val Arg Trp Phe  Lys Gly Ser 
    1160                 1165                 1170             


Gln Glu  Leu Gln Pro Gly Pro  Lys Tyr Glu Leu Val  Ser Asp Gly 
    1175                 1180                 1185             


Leu Tyr  Arg Lys Leu Ile Ile  Ser Asp Val His Ala  Glu Asp Glu 
    1190                 1195                 1200             


Asp Thr  Tyr Thr Cys Asp Ala  Gly Asp Val Lys Thr  Ser Ala Gln 
    1205                 1210                 1215             


Phe Phe  Val Glu Glu Gln Ser  Ile Thr Ile Val Arg  Gly Leu Gln 
    1220                 1225                 1230             


Asp Val  Thr Val Met Glu Pro  Ala Pro Ala Trp Phe  Glu Cys Glu 
    1235                 1240                 1245             


Thr Ser  Ile Pro Ser Val Arg  Pro Pro Lys Trp Leu  Leu Gly Lys 
    1250                 1255                 1260             


Thr Val  Leu Gln Ala Gly Gly  Asn Val Gly Leu Glu  Gln Glu Gly 
    1265                 1270                 1275             


Thr Val  His Arg Leu Met Leu  Arg Arg Thr Cys Ser  Thr Met Thr 
    1280                 1285                 1290             


Gly Pro  Val His Phe Thr Val  Gly Lys Ser Arg Ser  Ser Ala Arg 
    1295                 1300                 1305             


Leu Val  Val Ser Asp Ile Pro  Val Val Leu Thr Arg  Pro Leu Glu 
    1310                 1315                 1320             


Pro Lys  Thr Gly Arg Glu Leu  Gln Ser Val Val Leu  Ser Cys Asp 
    1325                 1330                 1335             


Phe Arg  Pro Ala Pro Lys Ala  Val Gln Trp Tyr Lys  Asp Asp Thr 
    1340                 1345                 1350             


Pro Leu  Ser Pro Ser Glu Lys  Phe Lys Met Ser Leu  Glu Gly Gln 
    1355                 1360                 1365             


Met Ala  Glu Leu Arg Ile Leu  Arg Leu Met Pro Ala  Asp Ala Gly 
    1370                 1375                 1380             


Val Tyr  Arg Cys Gln Ala Gly  Ser Ala His Ser Ser  Thr Glu Val 
    1385                 1390                 1395             


Thr Val  Glu Ala Arg Glu Val  Thr Val Thr Gly Pro  Leu Gln Asp 
    1400                 1405                 1410             


Ala Glu  Ala Thr Glu Glu Gly  Trp Ala Ser Phe Ser  Cys Glu Leu 
    1415                 1420                 1425             


Ser His  Glu Asp Glu Glu Val  Glu Trp Ser Leu Asn  Gly Met Pro 
    1430                 1435                 1440             


Leu Tyr  Asn Asp Ser Phe His  Glu Ile Ser His Lys  Gly Arg Arg 
    1445                 1450                 1455             


His Thr  Leu Val Leu Lys Ser  Ile Gln Arg Ala Asp  Ala Gly Ile 
    1460                 1465                 1470             


Val Arg  Ala Ser Ser Leu Lys  Val Ser Thr Ser Ala  Arg Leu Glu 
    1475                 1480                 1485             


Val Arg  Val Lys Pro Val Val  Phe Leu Lys Ala Leu  Asp Asp Leu 
    1490                 1495                 1500             


Ser Ala  Glu Glu Arg Gly Thr  Leu Ala Leu Gln Cys  Glu Val Ser 
    1505                 1510                 1515             


Asp Pro  Glu Ala His Val Val  Trp Arg Lys Asp Gly  Val Gln Leu 
    1520                 1525                 1530             


Gly Pro  Ser Asp Lys Tyr Asp  Phe Leu His Thr Ala  Gly Thr Arg 
    1535                 1540                 1545             


Gly Leu  Val Val His Asp Val  Ser Pro Glu Asp Ala  Gly Leu Tyr 
    1550                 1555                 1560             


Thr Cys  His Val Gly Ser Glu  Glu Thr Arg Ala Arg  Val Arg Val 
    1565                 1570                 1575             


His Asp  Leu His Val Gly Ile  Thr Lys Arg Leu Lys  Thr Met Glu 
    1580                 1585                 1590             


Val Leu  Glu Gly Glu Ser Cys  Ser Phe Glu Cys Val  Leu Ser His 
    1595                 1600                 1605             


Glu Ser  Ala Ser Asp Pro Ala  Met Trp Thr Val Gly  Gly Lys Thr 
    1610                 1615                 1620             


Val Gly  Ser Ser Ser Arg Phe  Gln Ala Thr Arg Gln  Gly Arg Lys 
    1625                 1630                 1635             


Tyr Ile  Leu Val Val Arg Glu  Ala Ala Pro Ser Asp  Ala Gly Glu 
    1640                 1645                 1650             


Val Val  Phe Ser Val Arg Gly  Leu Thr Ser Lys Ala  Ser Leu Ile 
    1655                 1660                 1665             


Val Arg  Glu Arg Pro Ala Ala  Ile Ile Lys Pro Leu  Glu Asp Gln 
    1670                 1675                 1680             


Trp Val  Ala Pro Gly Glu Asp  Val Glu Leu Arg Cys  Glu Leu Ser 
    1685                 1690                 1695             


Arg Ala  Gly Thr Pro Val His  Trp Leu Lys Asp Arg  Lys Ala Ile 
    1700                 1705                 1710             


Arg Lys  Ser Gln Lys Tyr Asp  Val Val Cys Glu Gly  Thr Met Ala 
    1715                 1720                 1725             


Met Leu  Val Ile Arg Gly Ala  Ser Leu Lys Asp Ala  Gly Glu Tyr 
    1730                 1735                 1740             


Thr Cys  Glu Val Glu Ala Ser  Lys Ser Thr Ala Ser  Leu His Val 
    1745                 1750                 1755             


Glu Glu  Lys Ala Asn Cys Phe  Thr Glu Glu Leu Thr  Asn Leu Gln 
    1760                 1765                 1770             


Val Glu  Glu Lys Gly Thr Ala  Val Phe Thr Cys Lys  Thr Glu His 
    1775                 1780                 1785             


Pro Ala  Ala Thr Val Thr Trp  Arg Lys Gly Leu Leu  Glu Leu Arg 
    1790                 1795                 1800             


Ala Ser  Gly Lys His Gln Pro  Ser Gln Glu Gly Leu  Thr Leu Arg 
    1805                 1810                 1815             


Leu Thr  Ile Ser Ala Leu Glu  Lys Ala Asp Ser Asp  Thr Tyr Thr 
    1820                 1825                 1830             


Cys Asp  Ile Gly Gln Ala Gln  Ser Arg Ala Gln Leu  Leu Val Gln 
    1835                 1840                 1845             


Gly Arg  Arg Val His Ile Ile  Glu Asp Leu Glu Asp  Val Asp Val 
    1850                 1855                 1860             


Gln Glu  Gly Ser Ser Ala Thr  Phe Arg Cys Arg Ile  Ser Pro Ala 
    1865                 1870                 1875             


Asn Tyr  Glu Pro Val His Trp  Phe Leu Asp Lys Thr  Pro Leu His 
    1880                 1885                 1890             


Ala Asn  Glu Leu Asn Glu Ile  Asp Ala Gln Pro Gly  Gly Tyr His 
    1895                 1900                 1905             


Val Leu  Thr Leu Arg Gln Leu  Ala Leu Lys Asp Ser  Gly Thr Ile 
    1910                 1915                 1920             


Tyr Phe  Glu Ala Gly Asp Gln  Arg Ala Ser Ala Ala  Leu Arg Val 
    1925                 1930                 1935             


Thr Glu  Lys Pro Ser Val Phe  Ser Arg Glu Leu Thr  Asp Ala Thr 
    1940                 1945                 1950             


Ile Thr  Glu Gly Glu Asp Leu  Thr Leu Val Cys Glu  Thr Ser Thr 
    1955                 1960                 1965             


Cys Asp  Ile Pro Val Cys Trp  Thr Lys Asp Gly Lys  Thr Leu Arg 
    1970                 1975                 1980             


Gly Ser  Ala Arg Cys Gln Leu  Ser His Glu Gly His  Arg Ala Gln 
    1985                 1990                 1995             


Leu Leu  Ile Thr Gly Ala Thr  Leu Gln Asp Ser Gly  Arg Tyr Lys 
    2000                 2005                 2010             


Cys Glu  Ala Gly Gly Ala Cys  Ser Ser Ser Ile Val  Arg Val His 
    2015                 2020                 2025             


Ala Arg  Pro Val Arg Phe Gln  Glu Ala Leu Lys Asp  Leu Glu Val 
    2030                 2035                 2040             


Leu Glu  Gly Gly Ala Ala Thr  Leu Arg Cys Val Leu  Ser Ser Val 
    2045                 2050                 2055             


Ala Ala  Pro Val Lys Trp Cys  Tyr Gly Asn Asn Val  Leu Arg Pro 
    2060                 2065                 2070             


Gly Asp  Lys Tyr Ser Leu Arg  Gln Glu Gly Ala Met  Leu Glu Leu 
    2075                 2080                 2085             


Val Val  Arg Asn Leu Arg Pro  Gln Asp Ser Gly Arg  Tyr Ser Cys 
    2090                 2095                 2100             


Ser Phe  Gly Asp Gln Thr Thr  Ser Ala Thr Leu Thr  Val Thr Ala 
    2105                 2110                 2115             


Leu Pro  Ala Gln Phe Ile Gly  Lys Leu Arg Asn Lys  Glu Ala Thr 
    2120                 2125                 2130             


Glu Gly  Ala Thr Ala Thr Leu  Arg Cys Glu Leu Ser  Lys Ala Ala 
    2135                 2140                 2145             


Pro Val  Glu Trp Arg Lys Gly  Ser Glu Thr Leu Arg  Asp Gly Asp 
    2150                 2155                 2160             


Arg Tyr  Cys Leu Arg Gln Asp  Gly Ala Met Cys Glu  Leu Gln Ile 
    2165                 2170                 2175             


Arg Gly  Leu Ala Met Val Asp  Ala Ala Glu Tyr Ser  Cys Val Cys 
    2180                 2185                 2190             


Gly Glu  Glu Arg Thr Ser Ala  Ser Leu Thr Ile Arg  Pro Met Pro 
    2195                 2200                 2205             


Ala His  Phe Ile Gly Arg Leu  Arg His Gln Glu Ser  Ile Glu Gly 
    2210                 2215                 2220             


Ala Thr  Ala Thr Leu Arg Cys  Glu Leu Ser Lys Ala  Ala Pro Val 
    2225                 2230                 2235             


Glu Trp  Arg Lys Gly Arg Glu  Ser Leu Arg Asp Gly  Asp Arg His 
    2240                 2245                 2250             


Ser Leu  Arg Gln Asp Gly Ala  Val Cys Glu Leu Gln  Ile Cys Gly 
    2255                 2260                 2265             


Leu Ala  Val Ala Asp Ala Gly  Glu Tyr Ser Cys Val  Cys Gly Glu 
    2270                 2275                 2280             


Glu Arg  Thr Ser Ala Thr Leu  Thr Val Lys Ala Leu  Pro Ala Lys 
    2285                 2290                 2295             


Phe Thr  Glu Gly Leu Arg Asn  Glu Glu Ala Val Glu  Gly Ala Thr 
    2300                 2305                 2310             


Ala Met  Leu Trp Cys Glu Leu  Ser Lys Val Ala Pro  Val Glu Trp 
    2315                 2320                 2325             


Arg Lys  Gly Pro Glu Asn Leu  Arg Asp Gly Asp Arg  Tyr Ile Leu 
    2330                 2335                 2340             


Arg Gln  Glu Gly Thr Arg Cys  Glu Leu Gln Ile Cys  Gly Leu Ala 
    2345                 2350                 2355             


Met Ala  Asp Ala Gly Glu Tyr  Leu Cys Val Cys Gly  Gln Glu Arg 
    2360                 2365                 2370             


Thr Ser  Ala Thr Leu Thr Ile  Arg Ala Leu Pro Ala  Arg Phe Ile 
    2375                 2380                 2385             


Glu Asp  Val Lys Asn Gln Glu  Ala Arg Glu Gly Ala  Thr Ala Val 
    2390                 2395                 2400             


Leu Gln  Cys Glu Leu Asn Ser  Ala Ala Pro Val Glu  Trp Arg Lys 
    2405                 2410                 2415             


Gly Ser  Glu Thr Leu Arg Asp  Gly Asp Arg Tyr Ser  Leu Arg Gln 
    2420                 2425                 2430             


Asp Gly  Thr Lys Cys Glu Leu  Gln Ile Arg Gly Leu  Ala Met Ala 
    2435                 2440                 2445             


Asp Thr  Gly Glu Tyr Ser Cys  Val Cys Gly Gln Glu  Arg Thr Ser 
    2450                 2455                 2460             


Ala Met  Leu Thr Val Arg Ala  Leu Pro Ile Lys Phe  Thr Glu Gly 
    2465                 2470                 2475             


Leu Arg  Asn Glu Glu Ala Thr  Glu Gly Ala Thr Ala  Val Leu Arg 
    2480                 2485                 2490             


Cys Glu  Leu Ser Lys Met Ala  Pro Val Glu Trp Trp  Lys Gly His 
    2495                 2500                 2505             


Glu Thr  Leu Arg Asp Gly Asp  Arg His Ser Leu Arg  Gln Asp Gly 
    2510                 2515                 2520             


Ala Arg  Cys Glu Leu Gln Ile  Arg Gly Leu Val Ala  Glu Asp Ala 
    2525                 2530                 2535             


Gly Glu  Tyr Leu Cys Met Cys  Gly Lys Glu Arg Thr  Ser Ala Met 
    2540                 2545                 2550             


Leu Thr  Val Arg Ala Met Pro  Ser Lys Phe Ile Glu  Gly Leu Arg 
    2555                 2560                 2565             


Asn Glu  Glu Ala Thr Glu Gly  Asp Thr Ala Thr Leu  Trp Cys Glu 
    2570                 2575                 2580             


Leu Ser  Lys Ala Ala Pro Val  Glu Trp Arg Lys Gly  His Glu Thr 
    2585                 2590                 2595             


Leu Arg  Asp Gly Asp Arg His  Ser Leu Arg Gln Asp  Gly Ser Arg 
    2600                 2605                 2610             


Cys Glu  Leu Gln Ile Arg Gly  Leu Ala Val Val Asp  Ala Gly Glu 
    2615                 2620                 2625             


Tyr Ser  Cys Val Cys Gly Gln  Glu Arg Thr Ser Ala  Thr Leu Thr 
    2630                 2635                 2640             


Val Arg  Ala Leu Pro Ala Arg  Phe Ile Glu Asp Val  Lys Asn Gln 
    2645                 2650                 2655             


Glu Ala  Arg Glu Gly Ala Thr  Ala Val Leu Gln Cys  Glu Leu Ser 
    2660                 2665                 2670             


Lys Ala  Ala Pro Val Glu Trp  Arg Lys Gly Ser Glu  Thr Leu Arg 
    2675                 2680                 2685             


Gly Gly  Asp Arg Tyr Ser Leu  Arg Gln Asp Gly Thr  Arg Cys Glu 
    2690                 2695                 2700             


Leu Gln  Ile His Gly Leu Ser  Val Ala Asp Thr Gly  Glu Tyr Ser 
    2705                 2710                 2715             


Cys Val  Cys Gly Gln Glu Arg  Thr Ser Ala Thr Leu  Thr Val Arg 
    2720                 2725                 2730             


Ala Leu  Pro Ala Arg His Ser  Arg Ser Glu Asp Gln  Gly Gly Leu 
    2735                 2740                 2745             


Arg Arg  Gly His Ser Tyr Thr  Ala Val 
    2750                 2755         


<210> 5986
<211> 482
<212> PRT
<213> Homo sapiens

<400> 5986
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
    130                 135                 140                 


Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
145                 150                 155                 160 


Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                165                 170                 175     


Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
            180                 185                 190         


Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
        195                 200                 205             


Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
    210                 215                 220                 


Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
225                 230                 235                 240 


Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                245                 250                 255     


Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Pro His Val Lys Ala Pro 
            260                 265                 270         


Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
        275                 280                 285             


Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
    290                 295                 300                 


Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
305                 310                 315                 320 


Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                325                 330                 335     


Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
            340                 345                 350         


Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
        355                 360                 365             


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
    370                 375                 380                 


Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
385                 390                 395                 400 


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                405                 410                 415     


Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
            420                 425                 430         


Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
        435                 440                 445             


Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
    450                 455                 460                 


Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
465                 470                 475                 480 


Arg Arg 
        


<210> 5987
<211> 268
<212> PRT
<213> Homo sapiens

<400> 5987
Met Ser Gly Arg Lys Arg Ser Phe Thr Phe Gly Ala Tyr Gly Gly Val 
1               5                   10                  15      


Asp Lys Ser Phe Thr Ser Arg Arg Ser Val Trp Arg Ser Asp Gly Gln 
            20                  25                  30          


Asn Gln His Phe Pro Gln Ala Leu Asp Leu Ser Arg Val Asn Leu Val 
        35                  40                  45              


Pro Ser Tyr Thr Pro Ser Leu Tyr Pro Lys Asn Thr Asp Leu Phe Glu 
    50                  55                  60                  


Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
65                  70                  75                  80  


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
                85                  90                  95      


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
            100                 105                 110         


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
        115                 120                 125             


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
    130                 135                 140                 


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
145                 150                 155                 160 


Lys Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu 
                165                 170                 175     


Val Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg 
            180                 185                 190         


Leu Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile 
        195                 200                 205             


Ser Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val 
    210                 215                 220                 


Cys Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys 
225                 230                 235                 240 


Ala Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn 
                245                 250                 255     


Phe Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln 
            260                 265             


<210> 5988
<211> 201
<212> PRT
<213> Homo sapiens

<400> 5988
Met Tyr Thr Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
1               5                   10                  15      


Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
            20                  25                  30          


Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys Asn Tyr Lys Gly Met 
        35                  40                  45              


Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu Asn Ile Gly Thr Val 
    50                  55                  60                  


Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
65                  70                  75                  80  


Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                85                  90                  95      


Ile Tyr Val Ile Asp Ser Thr Asp Glu Glu Arg Leu Ala Glu Ser Lys 
            100                 105                 110         


Gln Ala Phe Glu Lys Val Val Thr Ser Glu Ala Leu Cys Gly Val Pro 
        115                 120                 125             


Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Thr Cys Leu Ser Ile 
    130                 135                 140                 


Pro Asp Ile Lys Thr Ala Phe Ser Asp Cys Thr Ser Lys Ile Gly Arg 
145                 150                 155                 160 


Arg Asp Cys Leu Thr Gln Ala Cys Ser Ala Leu Thr Gly Lys Gly Val 
                165                 170                 175     


Arg Glu Gly Ile Glu Trp Met Val Lys Cys Val Val Arg Asn Val His 
            180                 185                 190         


Arg Pro Pro Arg Gln Arg Asp Ile Thr 
        195                 200     


<210> 5989
<211> 568
<212> PRT
<213> Homo sapiens

<400> 5989
Met Gly Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asn Leu Tyr Lys Asn Val 
            20                  25                  30          


Ile Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ala Val Ser 
        35                  40                  45              


Lys Gln Asp Leu Ile Thr Cys Leu Glu Gln Glu Lys Glu Pro Leu Thr 
    50                  55                  60                  


Val Lys Arg His Glu Met Val Asn Glu Pro Pro Val Met Cys Ser His 
65                  70                  75                  80  


Phe Ala Gln Glu Phe Trp Pro Glu Gln Asn Ile Lys Asp Ser Phe Glu 
                85                  90                  95      


Lys Val Thr Leu Arg Arg Tyr Glu Lys Cys Gly Asn Asp Asn Phe Gln 
            100                 105                 110         


Leu Lys Gly Cys Lys Ser Val Asp Glu Cys Lys Leu His Lys Gly Gly 
        115                 120                 125             


Tyr Asn Gly Leu Asn Gln Cys Leu Pro Thr Met Gln Ser Lys Met Phe 
    130                 135                 140                 


Gln Cys Asp Lys Tyr Val Lys Val Phe Asn Lys Phe Ser His Ser Asp 
145                 150                 155                 160 


Arg His Lys Ile Lys His Met Glu Asn Lys Pro Phe Lys Cys Lys Glu 
                165                 170                 175     


Cys Gly Arg Ser Phe Cys Met Leu Ser His Leu Thr Arg His Glu Arg 
            180                 185                 190         


Asn Tyr Thr Lys Val Asn Phe Cys Lys Cys Glu Glu Cys Glu Lys Ala 
        195                 200                 205             


Val Asn Gln Ser Ser Lys Leu Thr Lys His Lys Arg Ile Tyr Thr Cys 
    210                 215                 220                 


Glu Lys Leu Tyr Lys Cys Gln Glu Cys Asp Arg Thr Phe Asn Gln Phe 
225                 230                 235                 240 


Ser Asn Leu Thr Glu Tyr Lys Lys Asp Tyr Ala Arg Glu Lys Pro Tyr 
                245                 250                 255     


Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser His Leu Thr 
            260                 265                 270         


Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
        275                 280                 285             


Cys Gly Lys Ala Phe Asn Gln Phe Ser Asn Leu Thr Thr His Lys Lys 
    290                 295                 300                 


Ile His Thr Gly Glu Gln Pro Tyr Ile Cys Glu Glu Cys Gly Lys Ala 
305                 310                 315                 320 


Phe Thr Gln Ser Ser Thr Leu Thr Thr His Lys Arg Ile His Thr Gly 
                325                 330                 335     


Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser 
            340                 345                 350         


Ser Lys Leu Thr Glu His Lys Asn Ile His Thr Gly Glu Gln Pro Tyr 
        355                 360                 365             


Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Asn Leu Thr 
    370                 375                 380                 


Glu His Arg Lys Ile His Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu 
385                 390                 395                 400 


Cys Gly Lys Ala Phe Lys His Ser Ser Ala Leu Thr Thr His Lys Arg 
                405                 410                 415     


Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala 
            420                 425                 430         


Phe Asn Arg Ser Ser Lys Leu Thr Glu His Lys Lys Leu His Thr Gly 
        435                 440                 445             


Lys Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ile Gln Ser 
    450                 455                 460                 


Ser Lys Leu Thr Glu His Lys Lys Ile His Ser Gly Glu Ile Pro Tyr 
465                 470                 475                 480 


Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys His Ser Ser Ser Leu Thr 
                485                 490                 495     


Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
            500                 505                 510         


Cys Gly Lys Ala Phe Ser Arg Ser Ser Lys Leu Thr Glu His Lys Ile 
        515                 520                 525             


Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Arg Cys Asp Lys Ala 
    530                 535                 540                 


Phe Asn Gln Ser Ala Asn Leu Thr Lys His Lys Lys Ile His Thr Gly 
545                 550                 555                 560 


Glu Lys Leu Gln Asn Trp Asn Val 
                565             


<210> 5990
<211> 460
<212> PRT
<213> Homo sapiens

<400> 5990
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg Cys Thr Leu 
        115                 120                 125             


Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu Asn Val Glu 
    130                 135                 140                 


Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu Gln Arg Glu 
145                 150                 155                 160 


Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu Lys Leu Asp 
                165                 170                 175     


Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln Lys Thr Ala 
            180                 185                 190         


Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu Glu Glu His 
        195                 200                 205             


Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Leu Gln Thr Gly Leu 
    210                 215                 220                 


Glu Ile Ser Lys Ile Ile Met Ser Ser Val Ser Asn Leu Lys His Ser 
225                 230                 235                 240 


Lys Glu Lys Lys Lys Ser Ser Lys Lys Thr Lys Cys Ile Lys Arg Arg 
                245                 250                 255     


Pro Pro Trp Gln Ile Cys Ser Lys Phe Gly Ala Leu Pro Phe Val Ala 
            260                 265                 270         


Glu Lys Met Arg Gln His Arg Asp Pro His Ile Leu Gln Lys Pro Phe 
        275                 280                 285             


Asn Val Thr Glu Thr Arg Cys Leu Pro Lys Pro Ser Arg Thr Thr Ser 
    290                 295                 300                 


Trp Cys Lys Ala Ile Pro Pro Asp Ser Glu Lys Ser Ile Ser Ile Cys 
305                 310                 315                 320 


Asp Asn Leu Ser Glu Leu Leu Met Ala Met Gln Asp Glu Leu Asp Gln 
                325                 330                 335     


Met Ser Met Glu His Gln Glu Leu Leu Lys Gln Met Lys Glu Thr Glu 
            340                 345                 350         


Ser His Ser Val Cys Asp Asp Ile Glu Cys Glu Leu Glu Cys Leu Leu 
        355                 360                 365             


Lys Lys Met Glu Ile Lys Gly Glu Gln Ile Ser Lys Leu Lys Lys His 
    370                 375                 380                 


Gln Asp Ser Val Cys Lys Leu Gln Gln Lys Val Gln Asn Ser Lys Met 
385                 390                 395                 400 


Ser Glu Ala Ser Gly Ile Gln Gln Glu Asp Ser Tyr Pro Lys Gly Ser 
                405                 410                 415     


Lys Asn Ile Lys Asn Ser Pro Arg Lys Cys Leu Thr Asp Thr Asn Leu 
            420                 425                 430         


Phe Gln Lys Asn Ser Ser Phe His Pro Ile Arg Val His Asn Leu Gln 
        435                 440                 445             


Met Lys Leu Arg Arg Asp Asp Ile Met Trp Glu Gln 
    450                 455                 460 


<210> 5991
<211> 610
<212> PRT
<213> Homo sapiens

<400> 5991
Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Met Arg Arg Ala Val Asn Pro Asn 
        35                  40                  45              


His Ser Leu Arg Cys Cys Pro Phe Gln Gly His Ser Ser Cys Arg Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ala Glu Gly Thr Ala Leu Gly Pro Cys His Thr Ile 
65                  70                  75                  80  


Arg Ile Tyr Ile His Met Cys Leu Leu Trp Glu Gln Gly Gln Gln Ile 
                85                  90                  95      


Thr Met Met Arg Gly Ser Gln Glu Ser Ser Leu Arg Lys Thr Asp Ser 
            100                 105                 110         


Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile Ser Arg Ser Pro 
        115                 120                 125             


Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser Arg Asn Thr Ser 
    130                 135                 140                 


Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr Pro Ser Thr Ser 
145                 150                 155                 160 


Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser Gly Gln Pro Ser 
                165                 170                 175     


Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu Asp Ser Arg 
            180                 185                 190         


Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg Arg Ser Thr Lys 
        195                 200                 205             


Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile Val Arg Glu Ile 
    210                 215                 220                 


Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser Arg Thr Ser Pro 
225                 230                 235                 240 


Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile Tyr Pro Ala Ser 
                245                 250                 255     


Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln Gln Gln Gln Arg 
            260                 265                 270         


Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala Ser Met Arg Ser 
        275                 280                 285             


Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala Leu Phe Asn Met 
305                 310                 315                 320 


Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu Glu Lys Tyr Met 
                325                 330                 335     


Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr Pro Gly Pro Ala 
            340                 345                 350         


Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala Arg Leu Arg Asp 
        355                 360                 365             


Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val Leu Met Thr Asn 
    370                 375                 380                 


Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val Asn His Tyr 
385                 390                 395                 400 


Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys Asp Pro Ile 
                405                 410                 415     


Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala Ala Asp Ser 
            420                 425                 430         


Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser Ala Thr Met 
        435                 440                 445             


Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln Leu Arg Val 
    450                 455                 460                 


Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser Glu His Phe 
465                 470                 475                 480 


Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp Thr Leu Cys 
                485                 490                 495     


Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe Leu Glu Asp 
            500                 505                 510         


Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu Arg Leu Leu 
        515                 520                 525             


Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala Ala Ser Ser 
    530                 535                 540                 


Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly Leu Glu Ile Asp 
545                 550                 555                 560 


Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile Leu Val Lys 
                565                 570                 575     


Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe His Ile Glu Gly 
            580                 585                 590         


Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe Asn Lys Lys Phe 
        595                 600                 605             


Ser Ser 
    610 


<210> 5992
<211> 151
<212> PRT
<213> Homo sapiens

<400> 5992
Met Ser Lys Asn Thr Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg Gln 
        35                  40                  45              


Gly Asn Met Thr Ala Ala Leu Gln Ala Ala Leu Lys Asn Pro Pro Ile 
    50                  55                  60                  


Asn Thr Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser Ile Val Leu 
65                  70                  75                  80  


Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys Ala Val Gln 
                85                  90                  95      


Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr Ile Tyr Lys 
            100                 105                 110         


Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu Leu Gln Trp 
        115                 120                 125             


His Glu Lys Ala Leu Ala Ala Gly Gly Val Gly Ser Ile Val Arg Val 
    130                 135                 140                 


Leu Thr Ala Arg Lys Thr Val 
145                 150     


<210> 5993
<211> 1173
<212> PRT
<213> Homo sapiens

<400> 5993
Met Val Thr Val Gly Thr Asn Ile Leu Pro Ser Arg Pro Ala Ala Ser 
1               5                   10                  15      


Ala Asn Thr Ala Arg Glu Asp Ala Ala Leu Phe Ser Arg Arg Ile Pro 
            20                  25                  30          


Pro Arg His Lys Asn Gly Ala Ala Gln Pro Gly Ala Ala Pro Gly Pro 
        35                  40                  45              


Gly Ala Pro Gly Ala Asn Met Gly Asn Ala His Ser Lys Ser Gly Asp 
    50                  55                  60                  


Arg His Ser Ala Leu Pro Gly Arg Pro Glu Leu Ser Phe Tyr Gly Ser 
65                  70                  75                  80  


Phe Pro Arg Lys Trp Ser Glu Asn Val Phe Leu Asp Asn Glu Leu Leu 
                85                  90                  95      


Thr Ser Lys Ile Leu Ser Val Leu Arg Pro Gln Ser Glu Arg Gly Phe 
            100                 105                 110         


Arg Ala Gly Asp Leu Arg Tyr Pro Thr His Phe Leu Ser Thr Asn Ser 
        115                 120                 125             


Val Leu Ala Ser Val Thr Ala Ser Leu Lys Glu His Pro Arg Gly Thr 
    130                 135                 140                 


Leu Leu Ser Asp Gly Ser Pro Ala Leu Ser Arg Asn Val Gly Met Thr 
145                 150                 155                 160 


Val Ser Gln Lys Gly Gly Pro Gln Pro Thr Pro Ser Pro Ala Gly Pro 
                165                 170                 175     


Gly Thr Gln Leu Gly Pro Ile Thr Gly Glu Met Asp Glu Ala Asp Ser 
            180                 185                 190         


Ala Phe Leu Lys Phe Lys Gln Thr Ala Asp Asp Ser Leu Ser Leu Thr 
        195                 200                 205             


Ser Pro Asn Thr Glu Ser Ile Phe Val Glu Asp Pro Tyr Thr Ala Ser 
    210                 215                 220                 


Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala Glu Ser 
225                 230                 235                 240 


Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys Arg Glu 
                245                 250                 255     


Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Thr Glu Val 
            260                 265                 270         


His His Val Arg Thr Leu Lys Ile Met Leu Lys Val Tyr Ser Arg Ala 
        275                 280                 285             


Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg Leu Phe 
    290                 295                 300                 


Pro Cys Ala Asp Asp Leu Leu Glu Thr His Ser His Phe Leu Ala Arg 
305                 310                 315                 320 


Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp Arg Asn 
                325                 330                 335     


Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe Ser Gly 
            340                 345                 350         


Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys Ser Gly 
        355                 360                 365             


His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln Asn Lys 
    370                 375                 380                 


Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile Val Arg 
385                 390                 395                 400 


Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Thr Gln Arg Ile Thr 
                405                 410                 415     


Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Thr Glu Ala Gly 
            420                 425                 430         


Thr Glu Asp Tyr Glu Asp Leu Thr Gln Ala Leu Asn Leu Ile Lys Asp 
        435                 440                 445             


Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys Gly Gln 
    450                 455                 460                 


Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser Ser Lys 
465                 470                 475                 480 


Leu Lys Asn Gly Leu Thr Phe Arg Lys Glu Asp Met Leu Gln Arg Gln 
                485                 490                 495     


Leu His Leu Glu Gly Met Leu Cys Trp Lys Thr Thr Ser Gly Arg Leu 
            500                 505                 510         


Lys Asp Ile Leu Ala Ile Leu Leu Thr Asp Val Leu Leu Leu Leu Gln 
        515                 520                 525             


Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys Pro Pro 
    530                 535                 540                 


Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn Glu Glu 
545                 550                 555                 560 


Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu Met Tyr 
                565                 570                 575     


Glu Ile Tyr Thr Ser Ser Lys Glu Asp Arg Asn Ala Trp Met Ala His 
            580                 585                 590         


Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly Pro Phe 
        595                 600                 605             


Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala Thr Arg 
    610                 615                 620                 


Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu Ile Ala 
625                 630                 635                 640 


Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala Glu Met 
                645                 650                 655     


Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg Gly Gly 
            660                 665                 670         


Asp Pro Ser Glu Thr Leu Gln Gly Glu Leu Ile Leu Lys Ser Ala Met 
        675                 680                 685             


Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu Gly Ser 
    690                 695                 700                 


Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Thr Gly Pro Pro Arg 
705                 710                 715                 720 


Arg Ala Glu Thr Phe Ala Gly Tyr Asp Cys Thr Asn Ser Pro Thr Lys 
                725                 730                 735     


Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Thr Asp Pro Arg Pro Arg 
            740                 745                 750         


Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser Asp Ser 
        755                 760                 765             


Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu Ala Pro 
    770                 775                 780                 


Gly Thr Glu Ser Asp Pro Arg Leu Pro Thr Val Leu Glu Ser Glu Leu 
785                 790                 795                 800 


Val Gln Arg Ile Gln Thr Leu Ser Gln Leu Leu Leu Asn Leu Gln Ala 
                805                 810                 815     


Val Ile Ala His Gln Asp Ser Tyr Val Glu Thr Gln Arg Ala Ala Ile 
            820                 825                 830         


Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Thr Arg Gly Asn Leu 
        835                 840                 845             


Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg Glu Glu 
    850                 855                 860                 


Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu Gln Gln 
865                 870                 875                 880 


Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu Arg Ala 
                885                 890                 895     


Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu Arg Glu 
            900                 905                 910         


Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln Ala Tyr 
        915                 920                 925             


Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val Glu Arg 
    930                 935                 940                 


Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln Asn Thr 
945                 950                 955                 960 


Ala Pro Gly Ala Leu Pro Pro Asp Thr Leu Ala Glu Ala Gln Pro Pro 
                965                 970                 975     


Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro Arg Val 
            980                 985                 990         


Ser Met Leu Pro Ser Gly Val Gly  Pro Glu Tyr Ala Glu  Arg Pro Glu 
        995                 1000                 1005             


Val Ala  Arg Arg Asp Ser Ala  Pro Thr Glu Asn Arg  Leu Ala Lys 
    1010                 1015                 1020             


Ser Asp  Val Pro Ile Gln Leu  Leu Ser Ala Thr Asn  Gln Phe Gln 
    1025                 1030                 1035             


Arg Gln  Ala Ala Val Gln Gln  Gln Ile Pro Thr Lys  Leu Ala Ala 
    1040                 1045                 1050             


Ser Thr  Lys Gly Gly Lys Asp  Lys Gly Gly Lys Ser  Arg Gly Ser 
    1055                 1060                 1065             


Gln Arg  Trp Glu Ser Ser Ala  Ser Phe Asp Leu Lys  Gln Gln Leu 
    1070                 1075                 1080             


Leu Leu  Asn Lys Leu Met Gly  Lys Asp Glu Ser Thr  Ser Arg Asn 
    1085                 1090                 1095             


Arg Arg  Ser Leu Ser Pro Ile  Leu Pro Gly Arg His  Ser Pro Ala 
    1100                 1105                 1110             


Pro Pro  Pro Asp Pro Gly Phe  Pro Ala Pro Ser Pro  Pro Pro Ala 
    1115                 1120                 1125             


Asp Ser  Pro Ser Glu Gly Phe  Ser Leu Lys Ala Gly  Gly Thr Ala 
    1130                 1135                 1140             


Leu Leu  Pro Gly Pro Pro Ala  Pro Ser Pro Leu Pro  Ala Thr Pro 
    1145                 1150                 1155             


Leu Ser  Ala Lys Glu Asp Ala  Ser Lys Glu Asp Val  Ile Phe Phe 
    1160                 1165                 1170             


<210> 5994
<211> 557
<212> PRT
<213> Homo sapiens

<400> 5994
Met Asp Ser Thr Val Pro Ser Ala Leu Glu Leu Pro Gln Arg Leu Ala 
1               5                   10                  15      


Leu Asn Pro Arg Glu Ser Pro Arg Ser Pro Glu Glu Glu Glu Pro His 
            20                  25                  30          


Leu Leu Ser Ser Leu Ala Ala Val Gln Thr Leu Ala Ser Val Ile Arg 
        35                  40                  45              


Pro Cys Tyr Gly Pro His Gly Arg Gln Lys Phe Leu Val Thr Met Lys 
    50                  55                  60                  


Gly Glu Thr Val Cys Thr Gly Cys Ala Thr Ala Ile Leu Arg Ala Leu 
65                  70                  75                  80  


Glu Leu Glu His Pro Ala Ala Trp Leu Leu Arg Glu Ala Gly Gln Thr 
                85                  90                  95      


Gln Ala Glu Asn Ser Gly Asp Gly Thr Ala Phe Val Val Leu Leu Thr 
            100                 105                 110         


Glu Ala Leu Leu Glu Gln Ala Glu Gln Leu Leu Lys Ala Gly Leu Pro 
        115                 120                 125             


Arg Pro Gln Leu Arg Glu Ala Tyr Ala Thr Ala Thr Ala Glu Val Leu 
    130                 135                 140                 


Ala Thr Leu Pro Ser Leu Ala Ile Gln Ser Leu Gly Pro Leu Glu Asp 
145                 150                 155                 160 


Pro Ser Trp Ala Leu His Ser Val Met Asn Thr His Thr Leu Ser Pro 
                165                 170                 175     


Met Asp His Leu Thr Lys Leu Val Ala His Ala Cys Trp Ala Ile Lys 
            180                 185                 190         


Glu Leu Asp Gly Ser Phe Lys Pro Glu Arg Val Gly Val Cys Ala Leu 
        195                 200                 205             


Pro Gly Gly Thr Leu Glu Asp Ser Cys Leu Leu Pro Gly Leu Ala Ile 
    210                 215                 220                 


Ser Gly Lys Leu Cys Gly Gln Met Ala Thr Val Leu Ser Gly Ala Arg 
225                 230                 235                 240 


Val Ala Leu Phe Ala Cys Pro Phe Gly Pro Ala His Pro Asn Ala Pro 
                245                 250                 255     


Ala Thr Ala Arg Leu Ser Ser Pro Ala Asp Leu Ala Gln Phe Ser Lys 
            260                 265                 270         


Gly Ser Asp Gln Leu Leu Glu Lys Gln Val Gly Gln Leu Ala Ala Ala 
        275                 280                 285             


Gly Ile Asn Val Ala Val Val Leu Gly Glu Val Asp Glu Glu Thr Leu 
    290                 295                 300                 


Thr Leu Ala Asp Lys Tyr Gly Ile Val Val Ile Gln Ala Arg Ser Trp 
305                 310                 315                 320 


Met Glu Ile Ile Tyr Leu Ser Glu Val Leu Asp Thr Pro Leu Leu Pro 
                325                 330                 335     


Arg Leu Leu Pro Pro Gln Arg Pro Gly Lys Cys Gln Arg Val Tyr Arg 
            340                 345                 350         


Gln Glu Leu Gly Asp Gly Leu Ala Val Val Phe Glu Trp Glu Cys Thr 
        355                 360                 365             


Gly Thr Pro Ala Leu Thr Val Val Leu Arg Gly Ala Thr Thr Gln Gly 
    370                 375                 380                 


Leu Arg Ser Ala Glu Gln Ala Val Tyr His Gly Ile Asp Ala Tyr Phe 
385                 390                 395                 400 


Gln Leu Cys Gln Asp Pro Arg Leu Ile Pro Gly Ala Gly Ala Thr Glu 
                405                 410                 415     


Met Ala Leu Ala Lys Met Leu Ser Asp Lys Gly Ser Arg Leu Glu Gly 
            420                 425                 430         


Pro Ser Gly Pro Ala Phe Leu Ala Phe Ala Trp Ala Leu Lys Tyr Leu 
        435                 440                 445             


Pro Lys Thr Leu Ala Glu Asn Ala Gly Leu Ala Val Ser Asp Val Met 
    450                 455                 460                 


Ala Glu Met Ser Gly Val His Gln Gly Gly Asn Leu Leu Met Gly Val 
465                 470                 475                 480 


Gly Thr Glu Gly Ile Ile Asn Val Ala Gln Glu Gly Val Trp Asp Thr 
                485                 490                 495     


Leu Ile Val Lys Ala Gln Gly Phe Arg Ala Val Ala Glu Val Val Leu 
            500                 505                 510         


Gln Leu Val Thr Val Asp Glu Ile Val Val Ala Lys Lys Ser Pro Thr 
        515                 520                 525             


His Gln Glu Ile Trp Asn Pro Asp Ser Lys Lys Thr Lys Lys His Pro 
    530                 535                 540                 


Pro Pro Val Glu Thr Lys Lys Ile Leu Gly Leu Asn Asn 
545                 550                 555         


<210> 5995
<211> 312
<212> PRT
<213> Homo sapiens

<400> 5995
Met Thr Arg Ser Leu Phe Lys Gly Asn Phe Trp Ser Ala Asp Ile Leu 
1               5                   10                  15      


Ser Thr Ile Gly Tyr Asp Asn Ile Ile Gln His Leu Asn Asn Gly Arg 
            20                  25                  30          


Lys Asn Cys Lys Glu Phe Glu Asp Phe Leu Lys Glu Arg Ala Ala Ile 
        35                  40                  45              


Glu Glu Arg Tyr Gly Lys Asp Leu Leu Asn Leu Ser Arg Lys Lys Pro 
    50                  55                  60                  


Cys Gly Gln Ser Glu Ile Asn Thr Leu Lys Arg Ala Leu Glu Val Phe 
65                  70                  75                  80  


Lys Gln Gln Val Asp Asn Val Ala Gln Cys His Ile Gln Leu Ala Gln 
                85                  90                  95      


Ser Leu Arg Glu Glu Ala Arg Lys Met Glu Glu Phe Arg Glu Lys Gln 
            100                 105                 110         


Lys Leu Gln Arg Lys Lys Thr Glu Leu Ile Met Asp Ala Ile His Lys 
        115                 120                 125             


Gln Lys Ser Leu Gln Phe Lys Lys Thr Met Asp Ala Lys Lys Asn Tyr 
    130                 135                 140                 


Glu Gln Lys Cys Arg Asp Lys Asp Glu Ala Glu Gln Ala Val Ser Arg 
145                 150                 155                 160 


Ser Ala Asn Leu Val Asn Pro Lys Gln Gln Glu Lys Leu Phe Val Lys 
                165                 170                 175     


Leu Ala Thr Ser Lys Thr Ala Val Glu Asp Ser Asp Lys Ala Tyr Met 
            180                 185                 190         


Leu His Ile Gly Thr Leu Asp Lys Val Arg Glu Glu Trp Gln Ser Glu 
        195                 200                 205             


His Ile Lys Ala Cys Glu Ala Phe Glu Ala Gln Glu Cys Glu Arg Ile 
    210                 215                 220                 


Asn Phe Phe Arg Asn Ala Leu Trp Leu His Val Asn Gln Leu Ser Gln 
225                 230                 235                 240 


Gln Cys Val Thr Ser Asp Glu His Pro Ser Cys Met Arg Ile Ser Thr 
                245                 250                 255     


Pro Pro Arg Arg Met Gln Ser Gln Gln Glu Arg Leu Gln Gly Leu Thr 
            260                 265                 270         


Trp Gln Gly Glu Asp Pro Ser Gln Phe Leu Lys Ala His Gln Met Ile 
        275                 280                 285             


Pro Ile Thr Leu Trp Leu Met Thr Thr Val Cys Ser Ile Ser Lys Ile 
    290                 295                 300                 


Asn Glu Thr Arg Ala Phe Ser Gly 
305                 310         


<210> 5996
<211> 1230
<212> PRT
<213> Homo sapiens

<400> 5996
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu 
                165                 170                 175     


Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp 
            180                 185                 190         


Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp 
        195                 200                 205             


Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg 
    210                 215                 220                 


Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro 
225                 230                 235                 240 


Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp 
                245                 250                 255     


Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg 
            260                 265                 270         


Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Leu Asn Arg Val 
        275                 280                 285             


Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn Ile 
    290                 295                 300                 


Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys Asn 
305                 310                 315                 320 


His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala Glu 
                325                 330                 335     


Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile Asn 
            340                 345                 350         


Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys Asp 
        355                 360                 365             


Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile Glu 
    370                 375                 380                 


Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln Val 
385                 390                 395                 400 


Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Lys Leu Glu Lys 
                405                 410                 415     


Gln Leu Gln Lys Asp Lys Glu Lys Val Glu Glu Phe Lys Ser Ile Pro 
            420                 425                 430         


Ala Lys Ser Asn Asn Ile Ile Asn Glu Thr Thr Thr Arg Asn Asn Ala 
        435                 440                 445             


Leu Glu Lys Glu Lys Glu Lys Glu Glu Lys Lys Leu Lys Glu Val Met 
    450                 455                 460                 


Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu Ser 
465                 470                 475                 480 


Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala Arg 
                485                 490                 495     


Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser Arg 
            500                 505                 510         


His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu Ile 
        515                 520                 525             


Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp Ile 
    530                 535                 540                 


Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu Val 
                565                 570                 575     


His Asp Leu Phe Gln Lys Val Glu Glu Ala Lys Ser Ser Leu Ala Met 
            580                 585                 590         


Asn Arg Ser Arg Gly Lys Val Leu Asp Ala Ile Ile Gln Glu Lys Lys 
        595                 600                 605             


Ser Gly Arg Ile Pro Gly Ile Tyr Gly Arg Leu Gly Asp Leu Gly Ala 
    610                 615                 620                 


Ile Asp Glu Lys Tyr Asp Val Ala Ile Ser Ser Cys Cys His Ala Leu 
625                 630                 635                 640 


Asp Tyr Ile Val Val Asp Ser Ile Asp Ile Ala Gln Glu Cys Val Asn 
                645                 650                 655     


Phe Leu Lys Arg Gln Asn Ile Gly Val Ala Thr Phe Ile Gly Leu Asp 
            660                 665                 670         


Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro Glu 
        675                 680                 685             


Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys Ile 
    690                 695                 700                 


Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp Asn 
705                 710                 715                 720 


Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp Arg 
                725                 730                 735     


Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met Thr 
            740                 745                 750         


Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu Val 
        755                 760                 765             


Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu Gln 
    770                 775                 780                 


Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln Leu 
785                 790                 795                 800 


Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg Asn 
                805                 810                 815     


Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln Glu 
            820                 825                 830         


Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu Ala 
        835                 840                 845             


Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val Ser 
    850                 855                 860                 


Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Gly Lys Val 
865                 870                 875                 880 


Glu Ala Glu Val Lys Arg Leu His Asn Thr Ile Val Glu Ile Asn Asn 
                885                 890                 895     


His Lys Leu Lys Ala Gln Gln Asp Lys Leu Asp Lys Ile Asn Lys Gln 
            900                 905                 910         


Leu Asp Glu Cys Ala Ser Ala Ile Thr Lys Ala Gln Val Ala Ile Lys 
        915                 920                 925             


Thr Ala Asp Arg Asn Leu Gln Lys Ala Gln Asp Ser Val Leu Arg Thr 
    930                 935                 940                 


Glu Lys Glu Ile Lys Asp Thr Glu Lys Glu Val Asp Asp Leu Thr Ala 
945                 950                 955                 960 


Glu Leu Lys Ser Leu Glu Asp Lys Ala Ala Glu Val Val Lys Asn Thr 
                965                 970                 975     


Asn Ala Ala Glu Ile Ser Lys Ile Ser Leu His Pro Ile Glu Asp Asn 
            980                 985                 990         


Pro Ile Glu Glu Ile Ser Val Leu  Ser Pro Glu Asp Leu  Glu Ala Ile 
        995                 1000                 1005             


Lys Asn  Pro Asp Ser Ile Thr  Asn Gln Ile Ala Leu  Leu Glu Ala 
    1010                 1015                 1020             


Arg Cys  His Glu Met Lys Pro  Asn Leu Gly Ala Ile  Ala Glu Tyr 
    1025                 1030                 1035             


Lys Lys  Lys Glu Glu Leu Tyr  Leu Gln Arg Val Ala  Glu Leu Asp 
    1040                 1045                 1050             


Lys Ile  Thr Tyr Glu Arg Asp  Ser Phe Arg Gln Ala  Tyr Glu Asp 
    1055                 1060                 1065             


Leu Arg  Lys Gln Arg Leu Asn  Glu Phe Met Ala Gly  Phe Tyr Ile 
    1070                 1075                 1080             


Ile Thr  Asn Lys Leu Lys Glu  Asn Tyr Gln Met Leu  Thr Leu Gly 
    1085                 1090                 1095             


Gly Asp  Ala Glu Leu Glu Leu  Val Asp Ser Leu Asp  Pro Phe Ser 
    1100                 1105                 1110             


Glu Gly  Ile Met Phe Ser Val  Arg Pro Pro Lys Lys  Ser Trp Lys 
    1115                 1120                 1125             


Lys Ile  Phe Asn Leu Ser Gly  Gly Glu Lys Thr Leu  Ser Ser Leu 
    1130                 1135                 1140             


Ala Leu  Val Phe Ala Leu His  His Tyr Lys Pro Thr  Pro Leu Tyr 
    1145                 1150                 1155             


Phe Met  Asp Glu Ile Asp Ala  Ala Leu Asp Phe Lys  Asn Val Ser 
    1160                 1165                 1170             


Ile Val  Ala Phe Tyr Ile Tyr  Glu Gln Thr Lys Asn  Ala Gln Phe 
    1175                 1180                 1185             


Ile Ile  Ile Ser Leu Arg Asn  Asn Met Phe Glu Ile  Ser Asp Arg 
    1190                 1195                 1200             


Leu Ile  Gly Ile Tyr Lys Thr  Tyr Asn Ile Thr Lys  Ser Val Ala 
    1205                 1210                 1215             


Val Asn  Pro Lys Glu Ile Ala  Ser Lys Gly Leu Cys  
    1220                 1225                 1230 


<210> 5997
<211> 886
<212> PRT
<213> Homo sapiens

<400> 5997
Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser 
1               5                   10                  15      


Gly Asn Leu Ala His Val Glu Lys Val Glu Ser Leu Ser Ser Asp Gly 
            20                  25                  30          


Glu Gly Val Gly Gly Gly Ala Ser Ala Leu Thr Ser Gly Ile Ala Ser 
        35                  40                  45              


Ser Pro Asp Tyr Glu Phe Asn Val Trp Thr Arg Pro Asp Cys Ala Glu 
    50                  55                  60                  


Thr Glu Phe Glu Asn Gly Asn Arg Ser Trp Phe Tyr Phe Ser Val Arg 
65                  70                  75                  80  


Gly Gly Met Pro Gly Lys Leu Ile Lys Ile Asn Ile Met Asn Met Asn 
                85                  90                  95      


Lys Gln Ser Lys Leu Tyr Ser Gln Gly Met Ala Pro Phe Val Arg Thr 
            100                 105                 110         


Leu Pro Thr Arg Pro Arg Trp Glu Arg Ile Arg Asp Arg Pro Thr Phe 
        115                 120                 125             


Glu Met Thr Glu Thr Gln Phe Val Leu Ser Phe Val His Arg Phe Val 
    130                 135                 140                 


Glu Gly Arg Gly Ala Thr Thr Phe Phe Ala Phe Cys Tyr Pro Phe Ser 
145                 150                 155                 160 


Tyr Ser Asp Cys Gln Glu Leu Leu Asn Gln Leu Asp Gln Arg Phe Pro 
                165                 170                 175     


Glu Asn His Pro Thr His Ser Ser Pro Leu Asp Thr Ile Tyr Tyr His 
            180                 185                 190         


Arg Glu Leu Leu Cys Tyr Ser Leu Asp Gly Leu Arg Val Asp Leu Leu 
        195                 200                 205             


Thr Ile Thr Ser Cys His Gly Leu Arg Glu Asp Arg Glu Pro Arg Leu 
    210                 215                 220                 


Glu Gln Leu Phe Pro Asp Thr Ser Thr Pro Arg Pro Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Lys Arg Ile Phe Phe Leu Ser Ser Arg Val His Pro Gly Glu Thr 
                245                 250                 255     


Pro Ser Ser Phe Val Phe Asn Gly Phe Leu Asp Phe Ile Leu Arg Pro 
            260                 265                 270         


Asp Asp Pro Arg Ala Gln Thr Leu Arg Arg Leu Phe Val Phe Lys Leu 
        275                 280                 285             


Ile Pro Met Leu Asn Pro Asp Gly Val Val Arg Gly His Tyr Arg Thr 
    290                 295                 300                 


Asp Ser Arg Gly Val Asn Leu Asn Arg Gln Tyr Leu Lys Pro Asp Ala 
305                 310                 315                 320 


Val Leu His Pro Ala Ile Tyr Gly Ala Lys Ala Val Leu Leu Tyr His 
                325                 330                 335     


His Val His Ser Arg Leu Asn Ser Gln Ser Ser Ser Glu His Gln Pro 
            340                 345                 350         


Ser Ser Cys Leu Pro Pro Asp Ala Pro Val Ser Asp Leu Glu Lys Ala 
        355                 360                 365             


Asn Asn Leu Gln Asn Glu Ala Gln Cys Gly His Ser Ala Asp Arg His 
    370                 375                 380                 


Asn Ala Glu Ala Trp Lys Gln Thr Glu Pro Ala Glu Gln Lys Leu Asn 
385                 390                 395                 400 


Ser Val Trp Ile Met Pro Gln Gln Ser Ala Gly Leu Glu Glu Ser Ala 
                405                 410                 415     


Pro Asp Thr Ile Pro Pro Lys Glu Ser Gly Val Ala Tyr Tyr Val Asp 
            420                 425                 430         


Leu His Gly His Ala Ser Lys Arg Gly Cys Phe Met Tyr Gly Asn Ser 
        435                 440                 445             


Phe Ser Asp Glu Ser Thr Gln Val Glu Asn Met Leu Tyr Pro Lys Leu 
    450                 455                 460                 


Ile Ser Leu Asn Ser Ala His Phe Asp Phe Gln Gly Cys Asn Phe Ser 
465                 470                 475                 480 


Glu Lys Asn Met Tyr Ala Arg Asp Arg Arg Asp Gly Gln Ser Lys Glu 
                485                 490                 495     


Gly Ser Gly Arg Val Ala Ile Tyr Lys Ala Ser Gly Ile Ile His Ser 
            500                 505                 510         


Tyr Thr Leu Glu Cys Asn Tyr Asn Thr Gly Arg Ser Val Asn Ser Ile 
        515                 520                 525             


Pro Ala Ala Cys His Asp Asn Gly Arg Ala Ser Pro Pro Pro Pro Pro 
    530                 535                 540                 


Ala Phe Pro Ser Arg Tyr Thr Val Glu Leu Phe Glu Gln Val Gly Arg 
545                 550                 555                 560 


Ala Met Ala Ile Ala Ala Leu Asp Met Ala Glu Cys Asn Pro Trp Pro 
                565                 570                 575     


Arg Ile Val Leu Ser Glu His Ser Ser Leu Thr Asn Leu Arg Ala Trp 
            580                 585                 590         


Met Leu Lys His Val Arg Asn Ser Arg Gly Leu Ser Ser Thr Leu Asn 
        595                 600                 605             


Val Gly Val Asn Lys Lys Arg Gly Leu Arg Thr Pro Pro Lys Ser His 
    610                 615                 620                 


Asn Gly Leu Pro Val Ser Cys Ser Glu Asn Thr Leu Ser Arg Ala Arg 
625                 630                 635                 640 


Ser Phe Ser Thr Gly Thr Ser Ala Gly Gly Ser Ser Ser Ser Gln Gln 
                645                 650                 655     


Asn Ser Pro Gln Met Lys Asn Ser Pro Ser Phe Pro Phe His Gly Ser 
            660                 665                 670         


Arg Pro Ala Gly Leu Pro Gly Leu Gly Ser Ser Thr Gln Lys Val Thr 
        675                 680                 685             


His Arg Val Leu Gly Pro Val Arg Glu Pro Arg Ser Gln Asp Arg Arg 
    690                 695                 700                 


Arg Gln Gln Gln Pro Leu Asn His Arg Pro Ala Gly Ser Leu Ala Pro 
705                 710                 715                 720 


Ser Pro Ala Pro Thr Ser Ser Gly Pro Ala Ser Ser His Lys Leu Gly 
                725                 730                 735     


Ser Cys Leu Leu Pro Asp Ser Phe Asn Ile Pro Gly Ser Ser Cys Ser 
            740                 745                 750         


Leu Leu Ser Ser Gly Asp Lys Pro Glu Ala Val Met Val Ile Gly Lys 
        755                 760                 765             


Gly Leu Leu Gly Thr Gly Ala Arg Met Pro Cys Ile Lys Thr Arg Leu 
    770                 775                 780                 


Gln Ala Arg Pro Arg Leu Gly Arg Gly Ser Pro Pro Thr Arg Arg Gly 
785                 790                 795                 800 


Met Lys Gly Ser Ser Gly Pro Thr Ser Pro Thr Pro Arg Thr Arg Glu 
                805                 810                 815     


Ser Ser Glu Leu Glu Leu Gly Ser Cys Ser Ala Thr Pro Gly Leu Pro 
            820                 825                 830         


Gln Ala Arg Pro Pro Arg Pro Arg Ser Ala Pro Ala Phe Ser Pro Ile 
        835                 840                 845             


Ser Cys Ser Leu Ser Asp Ser Pro Ser Trp Asn Cys Tyr Ser Arg Gly 
    850                 855                 860                 


Pro Leu Gly Gln Pro Glu Val Cys Phe Val Pro Lys Ser Pro Pro Leu 
865                 870                 875                 880 


Thr Val Ser Pro Arg Val 
                885     


<210> 5998
<211> 1406
<212> PRT
<213> Homo sapiens

<400> 5998
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His Val Arg Thr Arg 
            820                 825                 830         


Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser Val Phe 
        835                 840                 845             


Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala Gln Trp Gln Arg 
    850                 855                 860                 


Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn Tyr Met Thr Gln 
865                 870                 875                 880 


Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp Pro Leu Ser Glu 
                885                 890                 895     


Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Val Lys Gly Val 
            900                 905                 910         


Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe Arg Pro Ala Ser 
        915                 920                 925             


Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser Met Glu Asn Leu 
    930                 935                 940                 


Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala Leu Gln Thr Ser 
945                 950                 955                 960 


Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg Ser Pro Leu Ile 
                965                 970                 975     


Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser Glu Thr Ser Ser 
            980                 985                 990         


Ser Arg Pro Gly Gly Tyr Arg Leu  Phe Ser Ser Ser Arg  Pro Pro Thr 
        995                 1000                 1005             


Glu Met  Lys Gln Ser Gly Leu  Gly Phe Glu Gly Cys  Ser Met Val 
    1010                 1015                 1020             


Pro Thr  Ile Tyr Pro Leu Glu  Thr Leu His Asn Ala  Leu Ser Leu 
    1025                 1030                 1035             


Arg Gln  Val Ser Glu Phe Leu  Ser Arg Val Cys Gln  Arg His Thr 
    1040                 1045                 1050             


Asp Ala  Gln Ala Gln Ala Ser  Ala Ala Leu Phe Asp  Ser Met His 
    1055                 1060                 1065             


Ser Ser  Gln Ala Ser Asp Asn  Pro Phe Ser Pro Pro  Arg Thr Leu 
    1070                 1075                 1080             


His Ser  Pro Pro Leu Gln Leu  Gln Gln Arg Ser Glu  Lys Pro Pro 
    1085                 1090                 1095             


Trp Leu  Glu Thr Arg Phe Cys  His Val Gly Gln Ala  Gly Leu Glu 
    1100                 1105                 1110             


Leu Leu  Thr Ser Ser Asp Leu  Pro Ala Ser Ala Ser  Gln Ser Ala 
    1115                 1120                 1125             


Gly Ile  Thr Gly Val Ser His  Arg Thr Gln Pro Asp  Ser Ser Gly 
    1130                 1135                 1140             


Pro Ser  Ser Thr Val Ser Ser  Ala Gly Pro Ser Ser  Pro Thr Thr 
    1145                 1150                 1155             


Val Asp  Gly Asn Ser Gln Phe  Gly Phe Ser Asp Gln  Pro Ser Leu 
    1160                 1165                 1170             


Asn Ser  His Val Ala Glu Glu  His Gln Gly Leu Gly  Leu Leu Gln 
    1175                 1180                 1185             


Glu Thr  Pro Gly Ser Gly Ala  Gln Glu Leu Ser Ile  Glu Gly Glu 
    1190                 1195                 1200             


Gln Glu  Leu Phe Glu Pro Asn  Gln Ser Pro Gln Val  Pro Pro Met 
    1205                 1210                 1215             


Glu Thr  Ser Gln Pro Tyr Glu  Glu Val Ser Gln Pro  Cys Gln Glu 
    1220                 1225                 1230             


Val Pro  Asp Ile Ser Gln Pro  Cys Gln Asp Ile Ser  Glu Ala Leu 
    1235                 1240                 1245             


Ser Gln  Pro Cys Gln Lys Val  Pro Asp Ile Ser Gln  Gln Cys Gln 
    1250                 1255                 1260             


Glu Asn  His Asp Asn Gly Asn  His Thr Cys Gln Glu  Val Pro His 
    1265                 1270                 1275             


Ile Ser  Gln Pro Cys Gln Lys  Ser Ser Gln Leu Cys  Gln Lys Val 
    1280                 1285                 1290             


Ser Glu  Glu Val Cys Gln Leu  Cys Leu Glu Asn Ser  Glu Glu Val 
    1295                 1300                 1305             


Ser Gln  Pro Cys Gln Gly Val  Ser Val Glu Val Gly  Lys Leu Val 
    1310                 1315                 1320             


His Lys  Phe His Val Gly Val  Gly Ser Leu Val Gln  Glu Thr Leu 
    1325                 1330                 1335             


Val Glu  Val Gly Ser Pro Ala  Glu Glu Ile Pro Glu  Glu Val Ile 
    1340                 1345                 1350             


Gln Pro  Tyr Gln Glu Phe Ser  Val Glu Val Gly Arg  Leu Ala Gln 
    1355                 1360                 1365             


Glu Thr  Ser Ala Ile Asn Leu  Leu Ser Gln Gly Ile  Pro Glu Ile 
    1370                 1375                 1380             


Asp Lys  Pro Ser Gln Glu Phe  Pro Glu Glu Ile Asp  Leu Gln Ala 
    1385                 1390                 1395             


Gln Glu  Val Pro Glu Glu Ile  Asn 
    1400                 1405     


<210> 5999
<211> 435
<212> PRT
<213> Homo sapiens

<400> 5999
Met Gly Asp Leu Glu Leu Leu Leu Pro Gly Glu Ala Glu Val Leu Val 
1               5                   10                  15      


Arg Gly Leu Arg Ser Phe Pro Leu Arg Glu Met Gly Ser Glu Gly Trp 
            20                  25                  30          


Asn Gln Gln His Glu Asn Leu Glu Lys Leu Asn Met Gln Ala Ile Leu 
        35                  40                  45              


Asp Ala Thr Val Ser Gln Gly Glu Pro Ile Gln Glu Leu Leu Val Thr 
    50                  55                  60                  


His Gly Lys Val Pro Thr Leu Val Glu Glu Leu Ile Ala Val Glu Met 
65                  70                  75                  80  


Trp Lys Gln Lys Val Phe Pro Val Phe Cys Arg Val Glu Asp Phe Lys 
                85                  90                  95      


Pro Gln Asn Thr Phe Pro Ile Tyr Met Val Val His His Glu Ala Ser 
            100                 105                 110         


Ile Ile Asn Leu Leu Glu Thr Val Phe Phe His Lys Glu Val Cys Glu 
        115                 120                 125             


Ser Ala Glu Asp Thr Val Leu Asp Leu Val Asp Tyr Cys His Arg Lys 
    130                 135                 140                 


Leu Thr Leu Leu Val Ala Gln Ser Gly Cys Gly Gly Pro Pro Glu Gly 
145                 150                 155                 160 


Glu Gly Ser Gln Asp Ser Asn Pro Met Gln Glu Leu Gln Lys Gln Ala 
                165                 170                 175     


Glu Leu Met Glu Phe Glu Ile Ala Leu Lys Ala Leu Ser Val Leu Arg 
            180                 185                 190         


Tyr Ile Thr Asp Cys Val Asp Arg Gln Trp Ser Val Ser Gln Pro Pro 
        195                 200                 205             


Gln Leu Ala His Leu Lys Arg Ile Gln Arg Leu His Pro Val Cys Trp 
    210                 215                 220                 


Phe Leu Ser Pro Gly Lys Leu Gln Gln Phe Glu Gly Ser Arg Trp His 
225                 230                 235                 240 


Thr Val Ala Pro Ser Glu Gln Gln Lys Leu Ser Lys Leu Asp Gly Gln 
                245                 250                 255     


Val Trp Ile Ala Leu Tyr Asn Leu Leu Leu Ser Pro Glu Ala Gln Ala 
            260                 265                 270         


Arg Tyr Cys Leu Thr Ser Phe Ala Lys Gly Arg Leu Leu Lys Leu Arg 
        275                 280                 285             


Ala Phe Leu Thr Asp Thr Leu Leu Asp Gln Leu Pro Asn Leu Ala His 
    290                 295                 300                 


Leu Gln Ser Phe Leu Ala His Leu Thr Leu Thr Glu Thr Gln Pro Pro 
305                 310                 315                 320 


Lys Lys Asp Leu Val Leu Glu Gln Ile Pro Glu Ile Trp Glu Arg Leu 
                325                 330                 335     


Glu Arg Glu Asn Arg Gly Lys Trp Gln Ala Ile Ala Lys His Gln Leu 
            340                 345                 350         


Gln His Val Phe Ser Pro Ser Glu Gln Asp Leu Arg Leu Gln Ala Arg 
        355                 360                 365             


Arg Trp Ala Glu Thr Tyr Arg Leu Asp Val Leu Glu Ala Val Ala Pro 
    370                 375                 380                 


Glu Arg Pro Arg Cys Ala Tyr Cys Ser Ala Glu Ala Ser Lys Arg Cys 
385                 390                 395                 400 


Ser Arg Cys Gln Asn Glu Trp Tyr Cys Cys Arg Glu Cys Gln Val Lys 
                405                 410                 415     


His Trp Glu Lys His Gly Lys Thr Cys Val Leu Ala Ala Gln Gly Asp 
            420                 425                 430         


Arg Ala Lys 
        435 


<210> 6000
<211> 458
<212> PRT
<213> Homo sapiens

<400> 6000
Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys 
1               5                   10                  15      


Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Glu Gln Ser Tyr 
            20                  25                  30          


Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Val Tyr 
        35                  40                  45              


Cys Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala 
    50                  55                  60                  


Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr 
65                  70                  75                  80  


Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala 
                85                  90                  95      


Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr 
            100                 105                 110         


Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu 
        115                 120                 125             


Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys 
    130                 135                 140                 


Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr 
145                 150                 155                 160 


Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His 
                165                 170                 175     


Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His 
            180                 185                 190         


Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp 
        195                 200                 205             


Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe 
    210                 215                 220                 


Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser 
225                 230                 235                 240 


Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu 
                245                 250                 255     


Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser 
            260                 265                 270         


Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly 
        275                 280                 285             


Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro 
    290                 295                 300                 


Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro 
305                 310                 315                 320 


Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg 
                325                 330                 335     


Thr Gly Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met 
            340                 345                 350         


Gly Gly Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp 
        355                 360                 365             


Phe Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln 
    370                 375                 380                 


Val Val Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val 
385                 390                 395                 400 


Glu His Met Met Glu Pro Gln Pro Leu Asn Gly Met Asn Cys Ser His 
                405                 410                 415     


Arg Leu Met Gln Thr Thr Leu Cys Ser Ser Leu Gln Met Gln Tyr Ser 
            420                 425                 430         


Ile Ile Ser Ser Cys Leu Leu Ala Trp Phe Pro Leu Glu Val Leu Gly 
        435                 440                 445             


Pro Leu Leu Asp Met Gly Leu Thr Thr Val 
    450                 455             


<210> 6001
<211> 102
<212> PRT
<213> Homo sapiens

<400> 6001
Met Arg Ala Ser Pro Cys Ile Ser Gln Pro Ala Ala Ser Trp His Pro 
1               5                   10                  15      


Arg Pro Ser Ala Leu Arg Pro Thr Ala Gly Ser Gly Pro Asp Thr Arg 
            20                  25                  30          


Thr Pro Gly Thr Val Glu Asp Gly Ser Ala Pro Cys Pro Ala Phe Arg 
        35                  40                  45              


Ser Pro Ala Val Ser Pro Cys Gly Glu Glu Pro Cys Cys Phe Gln Ile 
    50                  55                  60                  


Ser Pro Ala Glu Glu Thr Leu Glu Leu Gly Arg Leu Val Ser Pro Gly 
65                  70                  75                  80  


Cys His Lys Ser Ser Ala Pro Gln Glu Arg Arg Leu Asp Pro Arg Ala 
                85                  90                  95      


Arg Cys Val Val His Ile 
            100         


<210> 6002
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 6002
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His Val Arg Thr Arg 
            820                 825                 830         


Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser Val Phe 
        835                 840                 845             


Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala Gln Trp Gln Arg 
    850                 855                 860                 


Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn Tyr Met Thr Gln 
865                 870                 875                 880 


Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp Pro Leu Ser Glu 
                885                 890                 895     


Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Val Lys Gly Val 
            900                 905                 910         


Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe Arg Pro Ala Ser 
        915                 920                 925             


Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser Met Glu Asn Leu 
    930                 935                 940                 


Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala Leu Gln Thr Ser 
945                 950                 955                 960 


Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg Ser Pro Leu Ile 
                965                 970                 975     


Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser Glu Thr Ser Ser 
            980                 985                 990         


Ser Arg Pro Gly Gly Tyr Arg Leu  Phe Ser Ser Ser Arg  Pro Pro Thr 
        995                 1000                 1005             


Glu Met  Lys Gln Ser Gly Leu  Gly Ser Gln Cys Thr  Gly Leu Phe 
    1010                 1015                 1020             


Ser Thr  Thr Val Leu Gly Gly  Ser Ser Ser Ala Pro  Asn Leu Gln 
    1025                 1030                 1035             


Asp Tyr  Ala Arg Ser His Gly  Lys Lys Leu Pro Pro  Ala Ser Leu 
    1040                 1045                 1050             


Lys His  Arg Asp Gly Phe Glu  Gly Cys Ser Met Val  Pro Thr Ile 
    1055                 1060                 1065             


Tyr Pro  Leu Glu Thr Leu His  Asn Ala Leu Ser Leu  Arg Gln Val 
    1070                 1075                 1080             


Ser Glu  Phe Leu Ser Arg Val  Cys Gln Arg His Thr  Asp Ala Gln 
    1085                 1090                 1095             


Ala Gln  Ala Ser Ala Ala Leu  Phe Asp Ser Met His  Ser Ser Gln 
    1100                 1105                 1110             


Ala Ser  Asp Asn Pro Phe Ser  Pro Pro Arg Thr Leu  His Ser Pro 
    1115                 1120                 1125             


Pro Leu  Gln Leu Gln Gln Arg  Ser Glu Lys Pro Pro  Trp Tyr Ser 
    1130                 1135                 1140             


Ser Gly  Pro Ser Ser Thr Val  Ser Ser Ala Gly Pro  Ser Ser Pro 
    1145                 1150                 1155             


Thr Thr  Val Asp Gly Asn Ser  Gln Phe Gly Phe Ser  Asp Gln Pro 
    1160                 1165                 1170             


Ser Leu  Asn Ser His Val Ala  Glu Glu His Gln Gly  Leu Gly Leu 
    1175                 1180                 1185             


Leu Gln  Glu Thr Pro Gly Ser  Gly Ala Gln Glu Leu  Ser Ile Glu 
    1190                 1195                 1200             


Gly Glu  Gln Glu Leu Phe Glu  Pro Asn Gln Ser Pro  Gln Val Pro 
    1205                 1210                 1215             


Pro Met  Glu Thr Ser Gln Pro  Tyr Glu Glu Val Ser  Gln Pro Cys 
    1220                 1225                 1230             


Gln Glu  Val Pro Asp Ile Ser  Gln Pro Cys Gln Asp  Ile Ser Glu 
    1235                 1240                 1245             


Ala Leu  Ser Gln Pro Cys Gln  Lys Val Pro Asp Ile  Ser Gln Gln 
    1250                 1255                 1260             


Cys Gln  Glu Asn His Asp Asn  Gly Asn His Thr Cys  Gln Glu Val 
    1265                 1270                 1275             


Pro His  Ile Ser Gln Pro Cys  Gln Lys Ser Ser Gln  Leu Cys Gln 
    1280                 1285                 1290             


Lys Val  Ser Glu Glu Val Cys  Gln Leu Cys Leu Glu  Asn Ser Glu 
    1295                 1300                 1305             


Glu Val  Ser Gln Pro Cys Gln  Gly Val Ser Val Glu  Val Gly Lys 
    1310                 1315                 1320             


Leu Val  His Lys Phe His Val  Gly Val Gly Ser Leu  Val Gln Glu 
    1325                 1330                 1335             


Thr Leu  Val Glu Val Gly Ser  Pro Ala Glu Glu Ile  Pro Glu Glu 
    1340                 1345                 1350             


Val Ile  Gln Pro Tyr Gln Glu  Phe Ser Val Glu Val  Gly Arg Leu 
    1355                 1360                 1365             


Ala Gln  Glu Thr Ser Ala Ile  Asn Leu Leu Ser Gln  Gly Ile Pro 
    1370                 1375                 1380             


Glu Ile  Asp Lys Pro Ser Gln  Glu Phe Pro Glu Glu  Ile Asp Leu 
    1385                 1390                 1395             


Gln Ala  Gln Glu Val Pro Glu  Glu Ile Asn 
    1400                 1405             


<210> 6003
<211> 997
<212> PRT
<213> Homo sapiens

<400> 6003
Arg Pro Pro Pro Ala Gly Pro Gln Ala Pro Glu Gly Ala Arg Ala Gly 
1               5                   10                  15      


Ser Arg Pro Val Gln Leu Leu Ala Leu Leu Ser Ser Trp Cys Glu Glu 
            20                  25                  30          


Leu Gly Arg Leu Leu Leu Leu Arg His Gln Lys Ser Arg Gln Ser Asp 
        35                  40                  45              


Pro Pro Gly Lys Leu Pro Met Gln Pro Pro Leu Ser Ser Met Ser Ser 
    50                  55                  60                  


Met Lys Pro Thr Leu Ser His Ser Asp Gly Ser Phe Pro Tyr Asp Ser 
65                  70                  75                  80  


Val Pro Trp Gln Gln Asn Thr Asn Gln Pro Pro Gly Ser Leu Ser Val 
                85                  90                  95      


Val Thr Thr Val Trp Gly Val Thr Asn Thr Ser Gln Ser Gln Val Leu 
            100                 105                 110         


Gly Asn Pro Met Ala Asn Ala Asn Asn Pro Met Asn Pro Gly Gly Asn 
        115                 120                 125             


Pro Met Ala Ser Gly Met Thr Thr Ser Asn Pro Gly Leu Asn Ser Pro 
    130                 135                 140                 


Gln Phe Ala Gly Gln Gln Gln Gln Phe Ser Ala Lys Ala Gly Pro Ala 
145                 150                 155                 160 


Gln Pro Tyr Ile Gln Gln Ser Met Tyr Gly Arg Pro Asn Tyr Pro Gly 
                165                 170                 175     


Ser Gly Gly Phe Gly Ala Ser Tyr Pro Gly Gly Pro Asn Ala Pro Ala 
            180                 185                 190         


Gly Met Gly Ile Pro Pro His Thr Arg Pro Pro Ala Asp Phe Thr Gln 
        195                 200                 205             


Pro Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Thr 
    210                 215                 220                 


Ala Thr Ala Thr Ala Thr Ala Thr Val Ala Ala Leu Gln Glu Thr Gln 
225                 230                 235                 240 


Asn Lys Asp Ile Asn Gln Tyr Gly Pro Met Gly Pro Thr Gln Ala Tyr 
                245                 250                 255     


Asn Ser Gln Phe Met Asn Gln Pro Gly Pro Arg Gly Pro Ala Ser Met 
            260                 265                 270         


Gly Gly Ser Met Asn Pro Ala Ser Met Ala Ala Gly Met Thr Pro Ser 
        275                 280                 285             


Gly Met Ser Gly Pro Pro Met Gly Met Asn Gln Pro Arg Pro Pro Gly 
    290                 295                 300                 


Ile Ser Pro Phe Gly Thr His Gly Gln Arg Met Pro Gln Gln Thr Tyr 
305                 310                 315                 320 


Pro Gly Pro Arg Pro Gln Ser Leu Pro Ile Gln Asn Ile Lys Arg Pro 
                325                 330                 335     


Tyr Pro Gly Glu Pro Asn Tyr Gly Asn Gln Gln Tyr Gly Pro Asn Ser 
            340                 345                 350         


Gln Phe Pro Thr Gln Pro Gly Gln Tyr Pro Ala Pro Asn Pro Pro Arg 
        355                 360                 365             


Pro Leu Thr Ser Pro Asn Tyr Pro Gly Gln Arg Met Pro Ser Gln Pro 
    370                 375                 380                 


Ser Ser Gly Gln Tyr Pro Pro Pro Thr Val Asn Met Gly Gln Tyr Tyr 
385                 390                 395                 400 


Lys Pro Glu Gln Phe Asn Gly Gln Asn Asn Thr Phe Ser Gly Ser Ser 
                405                 410                 415     


Tyr Ser Asn Tyr Ser Gln Gly Asn Val Asn Arg Pro Pro Arg Pro Val 
            420                 425                 430         


Pro Val Ala Asn Tyr Pro His Ser Pro Val Pro Gly Asn Pro Thr Pro 
        435                 440                 445             


Pro Met Thr Pro Gly Ser Ser Ile Pro Pro Tyr Leu Ser Pro Ser Gln 
    450                 455                 460                 


Asp Val Lys Pro Pro Phe Pro Pro Asp Ile Lys Pro Asn Met Ser Ala 
465                 470                 475                 480 


Leu Pro Pro Pro Pro Ala Asn His Asn Asp Glu Leu Arg Leu Thr Phe 
                485                 490                 495     


Pro Val Arg Asp Gly Val Val Leu Glu Pro Phe Arg Leu Glu His Asn 
            500                 505                 510         


Leu Ala Val Ser Asn His Val Phe His Leu Arg Pro Thr Val His Gln 
        515                 520                 525             


Thr Leu Met Trp Arg Ser Asp Leu Glu Leu Gln Phe Lys Cys Tyr His 
    530                 535                 540                 


His Glu Asp Arg Gln Met Asn Thr Asn Trp Pro Ala Ser Val Gln Val 
545                 550                 555                 560 


Ser Val Asn Ala Thr Pro Leu Thr Ile Glu Arg Gly Asp Asn Lys Thr 
                565                 570                 575     


Ser His Lys Pro Leu His Leu Lys His Val Cys Gln Pro Gly Arg Asn 
            580                 585                 590         


Thr Ile Gln Ile Thr Val Thr Ala Cys Cys Cys Ser His Leu Phe Val 
        595                 600                 605             


Leu Gln Leu Val His Arg Pro Ser Val Arg Ser Val Leu Gln Gly Leu 
    610                 615                 620                 


Leu Lys Lys Arg Leu Leu Pro Ala Glu His Cys Ile Thr Lys Ile Lys 
625                 630                 635                 640 


Arg Asn Phe Ser Ser Val Ala Ala Ser Ser Gly Asn Thr Thr Leu Asn 
                645                 650                 655     


Gly Glu Asp Gly Val Glu Gln Thr Ala Ile Lys Val Ser Leu Lys Cys 
            660                 665                 670         


Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro Ala Arg Gly His Asp Cys 
        675                 680                 685             


Lys His Val Gln Cys Phe Asp Leu Glu Ser Tyr Leu Gln Leu Asn Cys 
    690                 695                 700                 


Glu Arg Gly Thr Trp Arg Cys Pro Val Cys Asn Lys Thr Ala Leu Leu 
705                 710                 715                 720 


Glu Gly Leu Glu Val Asp Gln Tyr Met Trp Gly Ile Leu Asn Ala Ile 
                725                 730                 735     


Gln His Ser Glu Phe Glu Glu Val Thr Ile Asp Pro Thr Cys Ser Trp 
            740                 745                 750         


Arg Pro Val Pro Ile Lys Ser Asp Leu His Ile Lys Asp Asp Pro Asp 
        755                 760                 765             


Gly Ile Pro Ser Lys Arg Phe Lys Thr Met Ser Pro Ser Gln Met Ile 
    770                 775                 780                 


Met Pro Asn Val Met Glu Met Ile Ala Ala Leu Gly Pro Gly Pro Ser 
785                 790                 795                 800 


Pro Tyr Pro Leu Pro Pro Pro Pro Gly Gly Thr Asn Ser Asn Asp Tyr 
                805                 810                 815     


Ser Ser Gln Gly Asn Asn Tyr Gln Gly His Gly Asn Phe Asp Phe Pro 
            820                 825                 830         


His Gly Asn Pro Gly Gly Thr Ser Met Asn Asp Phe Met His Gly Pro 
        835                 840                 845             


Pro Gln Leu Ser His Pro Pro Asp Met Pro Asn Asn Met Ala Ala Leu 
    850                 855                 860                 


Glu Lys Pro Leu Ser His Pro Met Gln Glu Thr Met Pro His Ala Gly 
865                 870                 875                 880 


Ser Ser Asp Gln Pro His Pro Ser Ile Gln Gln Gly Leu His Val Pro 
                885                 890                 895     


His Pro Ser Ser Gln Ser Gly Pro Pro Leu His His Ser Gly Ala Pro 
            900                 905                 910         


Pro Pro Pro Pro Ser Gln Pro Pro Arg Gln Pro Pro Gln Ala Ala Pro 
        915                 920                 925             


Ser Ser His Pro His Ser Asp Leu Thr Phe Asn Pro Ser Ser Ala Leu 
    930                 935                 940                 


Glu Gly Gln Ala Gly Ala Gln Gly Ala Ser Asp Met Pro Glu Pro Ser 
945                 950                 955                 960 


Leu Asp Leu Leu Pro Glu Leu Thr Asn Pro Asp Glu Leu Leu Ser Tyr 
                965                 970                 975     


Leu Asp Pro Pro Asp Leu Pro Ser Asn Ser Asn Asp Asp Leu Leu Ser 
            980                 985                 990         


Leu Phe Glu Asn Asn 
        995         


<210> 6004
<211> 1134
<212> PRT
<213> Homo sapiens

<400> 6004
Met Gly Lys Glu Gln Glu Leu Leu Glu Ala Ala Arg Thr Gly His Leu 
1               5                   10                  15      


Pro Ala Val Glu Lys Leu Leu Ser Gly Lys Arg Leu Ser Ser Gly Phe 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Leu Gly Ser Ser Ser His Pro Leu Ser Ser Leu 
    50                  55                  60                  


Leu Ser Met Trp Arg Gly Pro Asn Val Asn Cys Val Asp Ser Thr Gly 
65                  70                  75                  80  


Tyr Thr Pro Leu His His Ala Ala Leu Asn Gly His Lys Asp Val Val 
                85                  90                  95      


Glu Val Leu Leu Arg Asn Asp Ala Leu Thr Asn Val Ala Asp Ser Lys 
            100                 105                 110         


Gly Cys Tyr Pro Leu His Leu Ala Ala Trp Lys Gly Asp Ala Gln Ile 
        115                 120                 125             


Val Arg Leu Leu Ile His Gln Gly Pro Ser His Thr Arg Val Asn Glu 
    130                 135                 140                 


Gln Asn Asn Asp Asn Glu Thr Ala Leu His Cys Ala Ala Gln Tyr Gly 
145                 150                 155                 160 


His Thr Glu Val Val Lys Val Leu Leu Glu Glu Leu Thr Asp Pro Thr 
                165                 170                 175     


Met Arg Asn Asn Lys Phe Glu Thr Pro Leu Asp Leu Ala Ala Leu Tyr 
            180                 185                 190         


Gly Arg Leu Glu Val Val Lys Met Leu Leu Asn Ala His Pro Asn Leu 
        195                 200                 205             


Leu Ser Cys Asn Thr Lys Lys His Thr Pro Leu His Leu Ala Ala Arg 
    210                 215                 220                 


Asn Gly His Lys Ala Val Val Gln Val Leu Leu Asp Ala Gly Met Asp 
225                 230                 235                 240 


Ser Asn Tyr Gln Thr Glu Met Gly Ser Ala Leu His Glu Ala Ala Leu 
                245                 250                 255     


Phe Gly Lys Thr Asp Val Val Gln Ile Leu Leu Ala Ala Gly Thr Asp 
            260                 265                 270         


Val Asn Ile Lys Asp Asn His Gly Leu Thr Ala Leu Asp Thr Val Arg 
        275                 280                 285             


Glu Leu Pro Ser Gln Lys Ser Gln Gln Ile Ala Ala Leu Ile Glu Asp 
    290                 295                 300                 


His Met Thr Gly Lys Arg Ser Thr Lys Glu Val Asp Lys Thr Pro Pro 
305                 310                 315                 320 


Pro Gln Pro Pro Leu Ile Ser Ser Met Asp Ser Ile Ser Gln Lys Ser 
                325                 330                 335     


Gln Gly Asp Val Glu Lys Ala Val Thr Glu Leu Ile Ile Asp Phe Asp 
            340                 345                 350         


Ala Asn Ala Glu Glu Glu Gly Pro Tyr Glu Ala Leu Tyr Asn Ala Ile 
        355                 360                 365             


Ser Cys His Ser Leu Asp Ser Met Ala Ser Gly Arg Ser Ser Asp Gln 
    370                 375                 380                 


Asp Ser Thr Asn Lys Glu Ala Glu Ala Ala Gly Val Lys Pro Ala Gly 
385                 390                 395                 400 


Val Arg Pro Arg Glu Arg Pro Pro Pro Pro Ala Lys Pro Pro Pro Asp 
                405                 410                 415     


Glu Glu Glu Glu Asp His Ile Asp Lys Lys Tyr Phe Pro Leu Thr Ala 
            420                 425                 430         


Ser Glu Val Leu Ser Met Arg Pro Arg Ile His Gly Ser Ala Ala Arg 
        435                 440                 445             


Glu Glu Asp Glu His Pro Tyr Glu Leu Leu Leu Thr Ala Glu Thr Lys 
    450                 455                 460                 


Lys Val Val Leu Val Asp Gly Lys Thr Lys Asp His Arg Arg Ser Ser 
465                 470                 475                 480 


Ser Ser Arg Ser Gln Asp Ser Ala Glu Gly Gln Asp Gly Gln Val Pro 
                485                 490                 495     


Glu Gln Phe Ser Gly Leu Leu His Gly Ser Ser Pro Val Cys Glu Val 
            500                 505                 510         


Gly Gln Asp Pro Phe Gln Leu Leu Cys Thr Ala Gly Gln Ser His Pro 
        515                 520                 525             


Asp Gly Ser Pro Gln Gln Gly Ala Cys His Lys Ala Ser Met Gln Leu 
    530                 535                 540                 


Glu Glu Thr Gly Val His Ala Pro Gly Ala Ser Gln Pro Ser Ala Leu 
545                 550                 555                 560 


Asp Gln Ser Lys Arg Val Gly Tyr Leu Thr Gly Leu Pro Thr Thr Asn 
                565                 570                 575     


Ser Arg Ser His Pro Glu Thr Leu Thr His Thr Ala Ser Pro His Pro 
            580                 585                 590         


Gly Gly Ala Glu Glu Gly Asp Arg Ser Gly Ala Arg Ser Arg Ala Pro 
        595                 600                 605             


Pro Thr Ser Lys Pro Lys Ala Glu Leu Lys Leu Ser Arg Ser Leu Ser 
    610                 615                 620                 


Lys Ser Asp Ser Asp Leu Leu Thr Cys Ser Pro Thr Glu Asp Ala Thr 
625                 630                 635                 640 


Met Gly Ser Arg Ser Glu Ser Leu Ser Asn Cys Ser Ile Gly Lys Lys 
                645                 650                 655     


Arg Leu Glu Lys Ser Pro Ser Phe Ala Ser Glu Trp Asp Glu Ile Glu 
            660                 665                 670         


Lys Ile Met Ser Ser Ile Gly Glu Gly Ile Asp Phe Ser Gln Glu Arg 
        675                 680                 685             


Gln Lys Ile Ser Gly Leu Arg Thr Leu Glu Gln Ser Val Gly Glu Trp 
    690                 695                 700                 


Leu Glu Ser Ile Gly Leu Gln Gln Tyr Glu Ser Lys Leu Leu Leu Asn 
705                 710                 715                 720 


Gly Phe Asp Asp Val His Phe Leu Gly Ser Asn Val Met Glu Glu Gln 
                725                 730                 735     


Asp Leu Arg Asp Ile Gly Ile Ser Asp Pro Gln His Arg Arg Lys Leu 
            740                 745                 750         


Leu Gln Ala Ala Arg Ser Leu Pro Lys Val Lys Ala Leu Gly Tyr Asp 
        755                 760                 765             


Gly Asn Ser Pro Pro Ser Val Pro Ser Trp Leu Asp Ser Leu Gly Leu 
    770                 775                 780                 


Gln Asp Tyr Val His Ser Phe Leu Ser Ser Gly Tyr Ser Ser Ile Asp 
785                 790                 795                 800 


Thr Val Lys Asn Leu Trp Glu Leu Glu Leu Val Asn Val Leu Lys Val 
                805                 810                 815     


Gln Leu Leu Gly His Arg Lys Arg Ile Ile Ala Ser Leu Ala Asp Arg 
            820                 825                 830         


Pro Tyr Glu Glu Pro Pro Gln Lys Pro Pro Arg Phe Ser Gln Leu Arg 
        835                 840                 845             


Cys Gln Asp Leu Leu Ser Gln Thr Ser Ser Pro Leu Ser Gln Asn Asp 
    850                 855                 860                 


Ser Cys Thr Gly Arg Ser Ala Asp Leu Leu Leu Pro Pro Gly Asp Thr 
865                 870                 875                 880 


Gly Arg Arg Arg His Asp Ser Leu His Asp Pro Ala Ala Pro Ser Arg 
                885                 890                 895     


Ala Glu Arg Phe Arg Ile Gln Glu Glu His Arg Glu Ala Lys Leu Thr 
            900                 905                 910         


Leu Arg Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln Ser Trp 
        915                 920                 925             


Gln His Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr Glu Ala 
    930                 935                 940                 


Asn Tyr Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Thr Glu Ser 
945                 950                 955                 960 


Thr Gln Asp Ala Cys Ala Lys Met Arg Lys Ser Thr Glu His Met Lys 
                965                 970                 975     


Lys Ile Pro Thr Ile Ile Leu Ser Ile Thr Tyr Lys Gly Val Lys Phe 
            980                 985                 990         


Ile Asp Ala Ser Asn Lys Asn Val  Ile Ala Glu His Glu  Ile Arg Asn 
        995                 1000                 1005             


Ile Ser  Cys Ala Ala Gln Asp  Pro Glu Asp Leu Cys  Thr Phe Ala 
    1010                 1015                 1020             


Tyr Ile  Thr Lys Asp Leu Gln  Thr Ser His His Tyr  Cys His Val 
    1025                 1030                 1035             


Phe Ser  Thr Val Asp Val Asn  Leu Thr Tyr Glu Ile  Ile Leu Thr 
    1040                 1045                 1050             


Leu Gly  Gln Ala Phe Glu Val  Ala Tyr Gln Leu Ala  Leu Gln Ala 
    1055                 1060                 1065             


Gln Lys  Ser Arg Ala Thr Gly  Ala Ser Ala Ala Glu  Met Ile Glu 
    1070                 1075                 1080             


Thr Lys  Ser Ser Lys Pro Val  Pro Lys Pro Arg Val  Gly Val Arg 
    1085                 1090                 1095             


Lys Ser  Ala Leu Glu Pro Pro  Asp Met Asp Gln Asp  Ala Gln Ser 
    1100                 1105                 1110             


His Ala  Ser Val Ser Trp Val  Val Asp Pro Lys Pro  Asp Ser Lys 
    1115                 1120                 1125             


Arg Ser  Leu Ser Thr Asn 
    1130                 


<210> 6005
<211> 1032
<212> PRT
<213> Homo sapiens

<400> 6005
Met Glu Ala Ala Ala Ala Val Val Ala Ala Glu Ala Glu Val Glu Asn 
1               5                   10                  15      


Glu Asp Gly Asp Ser Ser Cys Gly Asp Val Cys Phe Met Asp Lys Gly 
            20                  25                  30          


Leu Gln Ser Ile Ser Glu Leu Ser Leu Asp Ser Thr Leu His Ala Val 
        35                  40                  45              


Asn Leu His Cys Asn Asn Ile Ser Lys Ile Glu Ala Ile Asp His Ile 
    50                  55                  60                  


Trp Asn Leu Gln His Leu Asp Leu Ser Ser Asn Gln Ile Ser Arg Ile 
65                  70                  75                  80  


Glu Gly Leu Asn Thr Leu Thr Lys Leu Cys Thr Leu Asn Leu Ser Cys 
                85                  90                  95      


Asn Leu Ile Thr Lys Val Glu Gly Leu Glu Glu Leu Ile Asn Leu Thr 
            100                 105                 110         


Arg Leu Asn Val Ser Tyr Asn His Ile Asp Asp Leu Ser Gly Leu Ile 
        115                 120                 125             


Pro Leu His Gly Ile Lys His Lys Leu Arg Tyr Ile Asp Leu His Ser 
    130                 135                 140                 


Asn Arg Ile Asp Ser Ile His His Leu Leu Gln Cys Met Val Gly Leu 
145                 150                 155                 160 


His Phe Leu Thr Asn Leu Ile Leu Glu Lys Asp Gly Asp Asp Asn Pro 
                165                 170                 175     


Val Cys Arg Leu Pro Gly Tyr Arg Ala Val Ile Leu Gln Thr Leu Pro 
            180                 185                 190         


Gln Leu Arg Ile Leu Asp Cys Lys Asn Ile Phe Gly Glu Pro Val Asn 
        195                 200                 205             


Leu Thr Glu Ile Asn Ser Ser Gln Leu Gln Cys Leu Glu Gly Leu Leu 
    210                 215                 220                 


Asp Asn Leu Val Ser Ser Asp Ser Pro Leu Asn Ile Ser Glu Asp Glu 
225                 230                 235                 240 


Ile Ile Asp Arg Met Pro Val Ile Thr Ala Pro Ile Asp Glu Leu Val 
                245                 250                 255     


Pro Leu Glu Gln Phe Ala Ser Thr Pro Ser Asp Ala Val Leu Thr Ser 
            260                 265                 270         


Phe Met Ser Val Cys Gln Ser Ser Glu Pro Glu Lys Asn Asn His Glu 
        275                 280                 285             


Asn Asp Leu Gln Asn Glu Ile Lys Leu Gln Lys Leu Asp Asp Gln Ile 
    290                 295                 300                 


Leu Gln Leu Leu Asn Glu Thr Ser Asn Ser Ile Asp Asn Val Leu Glu 
305                 310                 315                 320 


Lys Asp Pro Arg Pro Lys Arg Asp Thr Asp Ile Thr Ser Glu Ser Asp 
                325                 330                 335     


Tyr Gly Asn Arg Lys Glu Cys Asn Arg Lys Val Pro Arg Arg Ser Lys 
            340                 345                 350         


Ile Pro Tyr Asp Ala Lys Thr Ile Gln Thr Ile Lys His His Asn Lys 
        355                 360                 365             


Asn Tyr Asn Ser Phe Val Ser Cys Asn Arg Lys Met Lys Pro Pro Tyr 
    370                 375                 380                 


Leu Lys Glu Leu Tyr Val Ser Ser Ser Leu Ala Asn Cys Pro Met Leu 
385                 390                 395                 400 


Gln Glu Ser Glu Lys Pro Lys Thr Glu Ile Ile Lys Val Asp Gln Ser 
                405                 410                 415     


His Ser Glu Asp Asn Thr Tyr Gln Ser Leu Val Glu Gln Leu Asp Gln 
            420                 425                 430         


Glu Arg Glu Lys Arg Trp Arg Ala Glu Gln Ala Glu Asn Lys Leu Met 
        435                 440                 445             


Asp Tyr Ile Asp Glu Leu His Lys His Ala Asn Glu Lys Glu Asp Ile 
    450                 455                 460                 


His Ser Leu Ala Leu Leu Thr Thr Asp Arg Leu Lys Glu Ile Ile Phe 
465                 470                 475                 480 


Arg Glu Arg Asn Ser Lys Gly Gln Leu Glu Val Met Val His Lys Leu 
                485                 490                 495     


Gln Asn Glu Ile Lys Lys Leu Thr Val Glu Leu Met Lys Ala Lys Asp 
            500                 505                 510         


Gln Gln Glu Asp His Leu Lys His Leu Arg Thr Leu Glu Lys Thr Leu 
        515                 520                 525             


Glu Lys Met Glu Arg Gln Lys Arg Gln Gln Gln Ala Ala Gln Ile Arg 
    530                 535                 540                 


Leu Ile Gln Glu Val Glu Leu Lys Ala Ser Ala Ala Asp Arg Glu Ile 
545                 550                 555                 560 


Tyr Leu Leu Arg Thr Ser Leu His Arg Glu Arg Glu Gln Ala Gln Gln 
                565                 570                 575     


Leu His Gln Leu Leu Ala Leu Lys Glu Gln Glu His Arg Lys Glu Leu 
            580                 585                 590         


Glu Thr Arg Glu Phe Phe Thr Asp Ala Asp Phe Gln Asp Ala Leu Ala 
        595                 600                 605             


Lys Glu Ile Ala Lys Glu Glu Lys Lys His Glu Gln Met Ile Lys Glu 
    610                 615                 620                 


Tyr Gln Glu Lys Ile Asp Val Leu Ser Gln Gln Tyr Met Asp Leu Glu 
625                 630                 635                 640 


Asn Glu Phe Arg Ile Ala Leu Thr Val Glu Ala Arg Arg Phe Gln Asp 
                645                 650                 655     


Val Lys Asp Gly Phe Glu Asn Val Ala Thr Glu Leu Ala Lys Ser Lys 
            660                 665                 670         


His Ala Leu Ile Trp Ala Gln Arg Lys Glu Asn Glu Ser Ser Ser Leu 
        675                 680                 685             


Ile Lys Asp Leu Thr Cys Met Val Lys Glu Gln Lys Thr Lys Leu Ala 
    690                 695                 700                 


Glu Val Ser Lys Leu Lys Gln Glu Thr Ala Ala Asn Leu Gln Asn Gln 
705                 710                 715                 720 


Ile Asn Thr Leu Glu Ile Leu Ile Glu Asp Asp Lys Gln Lys Ser Ile 
                725                 730                 735     


Gln Ile Glu Leu Leu Lys His Glu Lys Val Gln Leu Ile Ser Glu Leu 
            740                 745                 750         


Ala Ala Lys Glu Ser Leu Ile Phe Gly Leu Arg Thr Glu Arg Lys Val 
        755                 760                 765             


Trp Gly His Glu Leu Ala Gln Gln Gly Ser Ser Leu Ala Gln Asn Arg 
    770                 775                 780                 


Gly Lys Leu Glu Ala Gln Ile Glu Ser Leu Ser Arg Glu Asn Glu Cys 
785                 790                 795                 800 


Leu Arg Lys Thr Asn Glu Ser Asp Ser Asp Ala Leu Arg Ile Lys Cys 
                805                 810                 815     


Lys Ile Ile Asp Asp Gln Thr Glu Thr Ile Arg Lys Leu Lys Asp Cys 
            820                 825                 830         


Leu Gln Glu Lys Asp Glu His Ile Lys Arg Leu Gln Glu Lys Ile Thr 
        835                 840                 845             


Glu Ile Glu Lys Cys Thr Gln Glu Gln Leu Asp Glu Lys Ser Ser Gln 
    850                 855                 860                 


Leu Asp Glu Val Leu Glu Lys Leu Glu Arg His Asn Glu Arg Lys Glu 
865                 870                 875                 880 


Lys Leu Lys Gln Gln Leu Lys Gly Lys Glu Val Glu Leu Glu Glu Ile 
                885                 890                 895     


Arg Lys Ala Tyr Ser Thr Leu Asn Arg Lys Trp His Asp Lys Gly Glu 
            900                 905                 910         


Leu Leu Cys His Leu Glu Thr Gln Val Lys Glu Val Lys Glu Lys Phe 
        915                 920                 925             


Glu Asn Lys Glu Lys Lys Leu Lys Ala Glu Arg Asp Lys Ser Ile Glu 
    930                 935                 940                 


Leu Gln Lys Asn Ala Met Glu Lys Leu His Ser Met Asp Asp Ala Phe 
945                 950                 955                 960 


Lys Arg Gln Val Asp Ala Ile Val Glu Ala His Gln Ala Glu Ile Ala 
                965                 970                 975     


Gln Leu Ala Asn Glu Lys Gln Lys Cys Ile Asp Ser Ala Asn Leu Lys 
            980                 985                 990         


Val His Gln Ile Glu Lys Glu Met  Arg Glu Leu Leu Glu  Glu Thr Cys 
        995                 1000                 1005             


Lys Asn  Lys Lys Thr Met Glu  Ala Lys Ile Lys Gln  Leu Ala Phe 
    1010                 1015                 1020             


Ala Leu  Asn Glu Ile Gln Gln  Asp Met 
    1025                 1030         


<210> 6006
<211> 72
<212> PRT
<213> Homo sapiens

<400> 6006
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Ser Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210> 6007
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6007
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 6008
<211> 496
<212> PRT
<213> Homo sapiens

<400> 6008
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser Gly 
        115                 120                 125             


Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu Phe 
    130                 135                 140                 


Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn Ala 
145                 150                 155                 160 


Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro Ala 
                165                 170                 175     


Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile Val 
            180                 185                 190         


Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile Ser 
        195                 200                 205             


Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu Tyr 
    210                 215                 220                 


Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val Met 
225                 230                 235                 240 


Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn Lys 
                245                 250                 255     


Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu Gly 
            260                 265                 270         


Phe Lys Val Pro Gln Ala Gln Pro Thr Lys Pro Ala Leu Lys Ser Glu 
        275                 280                 285             


Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr Phe 
    290                 295                 300                 


Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu Asp 
305                 310                 315                 320 


Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly Ile 
                325                 330                 335     


Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln Gly 
            340                 345                 350         


His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys Ala 
        355                 360                 365             


Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr Ser 
    370                 375                 380                 


Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His Val 
385                 390                 395                 400 


Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu Ser 
                405                 410                 415     


Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn Asn 
            420                 425                 430         


Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro Leu 
        435                 440                 445             


Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met Ala 
    450                 455                 460                 


Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser Thr 
465                 470                 475                 480 


Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg Cys 
                485                 490                 495     


<210> 6009
<211> 524
<212> PRT
<213> Homo sapiens

<400> 6009
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ile His Leu Gly Met 
            20                  25                  30          


Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val Asp 
        35                  40                  45              


Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu Val 
    50                  55                  60                  


Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly Arg 
65                  70                  75                  80  


Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly Gly 
                85                  90                  95      


Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr Ser 
            100                 105                 110         


Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro Thr 
        115                 120                 125             


Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val Gln 
    130                 135                 140                 


Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr Gly 
145                 150                 155                 160 


Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala Met 
                165                 170                 175     


Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro Arg 
            180                 185                 190         


Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile Gln 
        195                 200                 205             


Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu Lys 
    210                 215                 220                 


Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp Asp 
225                 230                 235                 240 


Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln Gly 
                245                 250                 255     


Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln Ala 
            260                 265                 270         


Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His Tyr 
        275                 280                 285             


Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val Gly 
    290                 295                 300                 


Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu Phe 
305                 310                 315                 320 


Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala Phe 
                325                 330                 335     


Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly Lys 
            340                 345                 350         


Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val Phe 
        355                 360                 365             


Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser Lys 
    370                 375                 380                 


Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala Glu 
385                 390                 395                 400 


Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu Ser 
                405                 410                 415     


Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg His 
            420                 425                 430         


Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val Glu 
        435                 440                 445             


Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser Leu 
    450                 455                 460                 


Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe Gly 
465                 470                 475                 480 


Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala Pro 
                485                 490                 495     


Gly Asn Leu Leu Thr Lys Gln Gly Ser Glu Asp Asn Leu Gln Gly Thr 
            500                 505                 510         


Asp Pro Pro Pro Val Gly Glu Glu Glu Val Leu Leu 
        515                 520                 


<210> 6010
<211> 633
<212> PRT
<213> Homo sapiens

<400> 6010
Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr Cys Asp Cys Lys Ile Phe Lys Ile 
        35                  40                  45              


Cys Leu Val Val Thr Lys Glu Val Ser Arg Asp Ser Ser Leu Leu Arg 
    50                  55                  60                  


Asp Asp Leu Ile Gln Asp Val Glu Ile Gln Ile Ile Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Pro Pro Ile Val Gln Asn Cys Cys Leu Pro Ala Val Val Glu Arg 
                85                  90                  95      


Ser Asp Asn Phe Cys Arg Ala Gly Leu Ala Val Val Leu Arg His Ile 
            100                 105                 110         


Ile Gln Lys Ser Tyr Glu Ala Asp Pro Leu Lys Lys Glu Leu Leu Glu 
        115                 120                 125             


Leu Leu Gly Phe Lys Lys Thr Cys Leu Lys Ala Cys Ala Glu Val Ser 
    130                 135                 140                 


Gln Trp Thr Arg Leu Cys Glu Leu Thr Ile Pro Leu Ala Ile Glu Asn 
145                 150                 155                 160 


Phe Leu Arg Glu Ser Ser Asp Gln Pro Pro Thr Ile Pro Val Glu Ile 
                165                 170                 175     


Leu Gln Leu Glu Lys Lys Leu Ser Glu Pro Val Arg Val His Asn Asp 
            180                 185                 190         


Asp Lys Leu Arg Arg Gln Lys Leu Lys Gln Gln Lys Ala Asp Gly Val 
        195                 200                 205             


Gly Pro Pro Leu Thr Lys Gly Lys Ala Lys Ser Lys Val His Thr Gln 
    210                 215                 220                 


Glu Thr Ser Glu Gly Leu Asp Ser Ser Ser Lys Ser Leu Glu Leu Lys 
225                 230                 235                 240 


Val Ala Phe Ser Lys Leu Thr Val Gln Glu Glu Pro Ala Thr Thr Asn 
                245                 250                 255     


Arg Glu Pro Ser His Ile Arg Lys Ala Lys Ala Ser Asp Leu Pro Pro 
            260                 265                 270         


Leu Glu His Val Phe Ala Glu Gly Leu Tyr Phe Thr Leu Ala Asp Ile 
        275                 280                 285             


Val Leu Leu Pro Cys Ile His His Phe Leu Val Ile Ile Ser Arg Lys 
    290                 295                 300                 


Phe Ser Glu Lys Leu Val Glu Phe Pro Leu Leu Ala Ser Trp Tyr Gln 
305                 310                 315                 320 


Arg Ile Gln Glu Val Pro Gly Val Lys Thr Ala Ala Ser Lys Cys Gly 
                325                 330                 335     


Ile Gln Phe Leu His Leu Pro Lys Leu Leu Thr Thr Ser Thr Glu Gln 
            340                 345                 350         


His Pro Asn Leu Cys Glu Val Pro Gly Val Glu Glu Gln Ser Asp Pro 
        355                 360                 365             


Leu Phe Ile Gly Gly Pro Arg Pro Thr Met Ala Lys Leu Met Glu Lys 
    370                 375                 380                 


Gly Ile Glu Val Met Phe Ser Pro His Pro Cys Pro Thr Trp Thr Leu 
385                 390                 395                 400 


Asp Trp Asn Val Leu Pro Ala Ala Val Ser Pro Lys Glu Gly Lys Met 
                405                 410                 415     


Ser Ser Asp Arg Ala Leu Arg Lys Gln Gln Gln Leu Asn Asn Leu Val 
            420                 425                 430         


Tyr Val Val Thr Asn Gln Ala Lys Pro Gly Asp Arg Ile Val Asp Phe 
        435                 440                 445             


Cys Ser Gly Gly Gly His Val Gly Ile Val Leu Ala His Met Leu Pro 
    450                 455                 460                 


Ser Cys Gln Val Thr Leu Ile Glu Asn Lys Glu Leu Ser Leu Ile Arg 
465                 470                 475                 480 


Ala Lys Lys Arg Ser Asp Glu Leu Gly Leu Ser Asn Ile Trp Phe Ile 
                485                 490                 495     


Gln Ala Asn Met Glu Tyr Phe Thr Gly Met Phe Asn Ile Gly Val Ala 
            500                 505                 510         


Leu His Ala Cys Gly Val Ala Thr Asp Met Val Ile Glu His Cys Ile 
        515                 520                 525             


Lys Thr Arg Ala Ser Phe Val Thr Cys Pro Cys Cys Tyr Gly Phe Ile 
    530                 535                 540                 


Gln Asn Thr Ser Lys Phe Asn Phe Pro Lys Ser Glu Gln Phe Lys Lys 
545                 550                 555                 560 


Thr Leu Ser Tyr Lys Glu His Met Ile Leu Cys Arg Phe Ala Asp Gln 
                565                 570                 575     


Thr Ala Val Gln Leu Pro Pro Gln Arg Arg Leu Ile Gly Lys Gln Cys 
            580                 585                 590         


Met Cys Leu Val Asp Leu Asp Arg Ala Arg Ala Ala Glu Glu Cys Gly 
        595                 600                 605             


Tyr Ser Val Gln Val Ile Ser Met Glu Pro Glu Ser Cys Ser Pro Lys 
    610                 615                 620                 


Asn Asn Met Ile Val Gly Val Pro Ile 
625                 630             


<210> 6011
<211> 172
<212> PRT
<213> Homo sapiens

<400> 6011
Met Ser Ser Gly Asn Tyr Gln Gln Ser Glu Ala Leu Ser Lys Pro Thr 
1               5                   10                  15      


Phe Ser Glu Glu Gln Ala Ser Ala Leu Val Glu Ser Val Phe Gly Leu 
            20                  25                  30          


Lys Val Ser Lys Val Arg Pro Leu Pro Ser Tyr Asp Asp Gln Asn Phe 
        35                  40                  45              


His Val Tyr Val Ser Lys Thr Lys Asp Gly Pro Thr Glu Tyr Val Leu 
    50                  55                  60                  


Lys Ile Ser Asn Thr Lys Ala Ser Lys Asn Pro Asp Leu Ile Glu Val 
65                  70                  75                  80  


Gln Asn His Ile Ile Met Phe Leu Lys Ala Ala Gly Phe Pro Thr Ala 
                85                  90                  95      


Ser Val Cys His Thr Lys Gly Asp Asn Thr Ala Ser Leu Val Ser Val 
            100                 105                 110         


Asp Ser Gly Ser Glu Ile Lys Ser Tyr Leu Val Arg Leu Leu Thr Tyr 
        115                 120                 125             


Leu Pro Gly Arg Pro Ile Ala Glu Leu Pro Val Ser Pro Gln Leu Leu 
    130                 135                 140                 


Tyr Glu Ile Gly Lys Leu Ala Ala Lys Leu Asp Lys Thr Leu Gln Glu 
145                 150                 155                 160 


Gly Lys Pro Arg Val Thr Pro Leu Leu Ala Lys Asn 
                165                 170         


<210> 6012
<211> 978
<212> PRT
<213> Homo sapiens

<400> 6012
Met Gly Trp Lys Pro Ser Glu Ala Arg Gly Gln Ser Gln Ser Phe Gln 
1               5                   10                  15      


Ala Ser Gly Leu Gln Pro Arg Ser Leu Lys Ala Ala Arg Arg Ala Thr 
            20                  25                  30          


Gly Arg Pro Asp Arg Ser Arg Ala Ala Arg Pro Thr Met Asp Pro Ser 
        35                  40                  45              


Ala His Arg Ser Arg Ala Ala Pro Pro Asn Met Asp Pro Asp Pro Gln 
    50                  55                  60                  


Ala Gly Val Gln Val Gly Met Arg Val Val Arg Gly Val Asp Trp Lys 
65                  70                  75                  80  


Trp Gly Gln Gln Asp Gly Gly Glu Gly Gly Val Gly Thr Val Val Glu 
                85                  90                  95      


Leu Gly Arg His Gly Ser Pro Ser Thr Pro Asp Arg Thr Val Val Val 
            100                 105                 110         


Gln Trp Asp Gln Gly Thr Arg Thr Asn Tyr Arg Ala Gly Tyr Gln Gly 
        115                 120                 125             


Ala His Asp Leu Leu Leu Tyr Asp Asn Ala Gln Ile Gly Val Arg His 
    130                 135                 140                 


Pro Asn Ile Ile Cys Asp Cys Cys Lys Lys His Gly Leu Arg Gly Met 
145                 150                 155                 160 


Arg Trp Lys Cys Arg Val Cys Leu Asp Tyr Asp Leu Cys Thr Gln Cys 
                165                 170                 175     


Tyr Met His Asn Lys His Glu Leu Ala His Ala Phe Asp Arg Tyr Glu 
            180                 185                 190         


Thr Ala His Ser Arg Pro Val Thr Leu Ser Pro Arg Gln Gly Leu Pro 
        195                 200                 205             


Arg Ile Pro Leu Arg Gly Ile Phe Gln Gly Ala Lys Val Val Arg Gly 
    210                 215                 220                 


Pro Asp Trp Glu Trp Gly Ser Gln Asp Gly Gly Glu Gly Lys Pro Gly 
225                 230                 235                 240 


Arg Val Val Asp Ile Arg Gly Trp Asp Val Glu Thr Gly Arg Ser Val 
                245                 250                 255     


Ala Ser Val Thr Trp Ala Asp Gly Thr Thr Asn Val Tyr Arg Val Gly 
            260                 265                 270         


His Lys Gly Lys Val Asp Leu Lys Cys Val Gly Glu Ala Ala Gly Gly 
        275                 280                 285             


Phe Tyr Tyr Lys Asp His Leu Pro Arg Leu Gly Lys Pro Ala Glu Leu 
    290                 295                 300                 


Gln Arg Arg Val Ser Ala Asp Ser Gln Pro Phe Gln His Gly Asp Lys 
305                 310                 315                 320 


Val Lys Cys Leu Leu Asp Thr Asp Val Leu Arg Glu Met Gln Glu Gly 
                325                 330                 335     


His Gly Gly Trp Asn Pro Arg Met Ala Glu Phe Ile Gly Gln Thr Gly 
            340                 345                 350         


Thr Val His Arg Ile Thr Asp Arg Gly Asp Val Arg Val Gln Phe Asn 
        355                 360                 365             


His Glu Thr Arg Trp Thr Phe His Pro Gly Ala Leu Thr Lys Ala Leu 
    370                 375                 380                 


Gly Arg Val Gly Lys Val Val Lys Val Phe Gly Asp Gly Asn Leu Arg 
385                 390                 395                 400 


Val Ala Val Ala Gly Gln Arg Trp Thr Phe Ser Pro Ser Cys Leu Val 
                405                 410                 415     


Ala Tyr Arg Pro Glu Glu Asp Ala Asn Leu Asp Val Ala Glu Arg Ala 
            420                 425                 430         


Arg Glu Asn Lys Ser Ser Leu Ser Val Ala Leu Asp Lys Leu Arg Ala 
        435                 440                 445             


Gln Lys Ser Asp Pro Glu His Pro Gly Arg Leu Val Val Glu Val Ala 
    450                 455                 460                 


Leu Gly Asn Ala Ala Arg Ala Leu Asp Leu Leu Arg Arg Arg Pro Glu 
465                 470                 475                 480 


Gln Val Asp Thr Lys Asn Gln Gly Arg Thr Ala Leu Gln Val Ala Ala 
                485                 490                 495     


Tyr Leu Gly Gln Val Glu Leu Ile Arg Leu Leu Leu Gln Ala Arg Ala 
            500                 505                 510         


Gly Val Asp Leu Pro Asp Asp Glu Gly Asn Thr Ala Leu His Tyr Ala 
        515                 520                 525             


Ala Leu Gly Asn Gln Pro Glu Ala Thr Arg Val Leu Leu Ser Ala Gly 
    530                 535                 540                 


Cys Arg Ala Asp Ala Ile Asn Ser Thr Gln Ser Thr Ala Leu His Val 
545                 550                 555                 560 


Ala Val Gln Arg Gly Phe Leu Glu Val Val Arg Ala Leu Cys Glu Arg 
                565                 570                 575     


Gly Cys Asp Val Asn Leu Pro Asp Ala His Ser Asp Thr Pro Leu His 
            580                 585                 590         


Ser Ala Ile Ser Ala Gly Thr Gly Ala Ser Gly Ile Val Glu Val Leu 
        595                 600                 605             


Thr Glu Val Pro Asn Ile Asp Val Thr Ala Thr Asn Ser Gln Gly Phe 
    610                 615                 620                 


Thr Leu Leu His His Ala Ser Leu Lys Gly His Ala Leu Ala Val Arg 
625                 630                 635                 640 


Lys Ile Leu Ala Arg Ala Arg Gln Leu Val Asp Ala Lys Lys Glu Asp 
                645                 650                 655     


Gly Phe Thr Ala Leu His Leu Ala Ala Leu Asn Asn His Arg Glu Val 
            660                 665                 670         


Ala Gln Ile Leu Ile Arg Glu Gly Arg Cys Asp Val Asn Val Arg Asn 
        675                 680                 685             


Arg Lys Leu Gln Ser Pro Leu His Leu Ala Val Gln Gln Ala His Val 
    690                 695                 700                 


Gly Leu Val Pro Leu Leu Val Asp Ala Gly Cys Ser Val Asn Ala Glu 
705                 710                 715                 720 


Asp Glu Glu Gly Asp Thr Ala Leu His Val Ala Leu Gln Arg His Gln 
                725                 730                 735     


Leu Leu Pro Leu Val Ala Asp Gly Ala Gly Gly Asp Pro Gly Pro Leu 
            740                 745                 750         


Gln Leu Leu Ser Arg Leu Gln Ala Ser Gly Leu Pro Gly Ser Ala Glu 
        755                 760                 765             


Leu Thr Val Gly Ala Ala Val Ala Cys Phe Leu Ala Leu Glu Gly Ala 
    770                 775                 780                 


Asp Val Ser Tyr Thr Asn His Arg Gly Arg Ser Pro Leu Asp Leu Ala 
785                 790                 795                 800 


Ala Glu Gly Arg Val Leu Lys Ala Leu Gln Gly Cys Ala Gln Arg Phe 
                805                 810                 815     


Arg Glu Arg Gln Ala Gly Gly Gly Ala Ala Pro Gly Pro Arg Gln Thr 
            820                 825                 830         


Leu Gly Thr Pro Asn Thr Val Thr Asn Leu His Val Gly Ala Ala Pro 
        835                 840                 845             


Gly Pro Glu Ala Ala Glu Cys Leu Val Cys Ser Glu Leu Ala Leu Leu 
    850                 855                 860                 


Val Leu Phe Ser Pro Cys Gln His Arg Thr Val Cys Glu Glu Cys Ala 
865                 870                 875                 880 


Arg Arg Met Lys Lys Cys Ile Arg Cys Gln Val Val Val Ser Lys Lys 
                885                 890                 895     


Leu Arg Pro Asp Gly Ser Glu Val Ala Ser Ala Ala Pro Ala Pro Gly 
            900                 905                 910         


Pro Pro Arg Gln Leu Val Glu Glu Leu Gln Ser Arg Tyr Arg Gln Met 
        915                 920                 925             


Glu Glu Arg Ile Thr Cys Pro Ile Cys Ile Asp Ser His Ile Arg Leu 
    930                 935                 940                 


Val Phe Gln Cys Gly His Gly Ala Cys Ala Pro Cys Gly Ser Ala Leu 
945                 950                 955                 960 


Ser Ala Cys Pro Ile Cys Arg Gln Pro Ile Arg Asp Arg Ile Gln Ile 
                965                 970                 975     


Phe Val 
        


<210> 6013
<211> 357
<212> PRT
<213> Homo sapiens

<400> 6013
Met Gly Gly Ala Val Ser Ala Gly Glu Asp Asn Asp Asp Leu Ile Asp 
1               5                   10                  15      


Asn Leu Lys Glu Ala Gln Tyr Ile Arg Thr Glu Arg Val Glu Gln Ala 
            20                  25                  30          


Phe Arg Ala Ile Asp Arg Gly Asp Tyr Tyr Leu Glu Gly Tyr Arg Asp 
        35                  40                  45              


Asn Ala Tyr Lys Asp Leu Ala Trp Lys His Gly Asn Ile His Leu Ser 
    50                  55                  60                  


Ala Pro Cys Ile Tyr Ser Glu Val Met Glu Ala Leu Lys Leu Gln Pro 
65                  70                  75                  80  


Gly Leu Ser Phe Leu Asn Leu Gly Ser Gly Thr Gly Tyr Leu Ser Thr 
                85                  90                  95      


Met Val Gly Leu Ile Leu Gly Pro Phe Gly Ile Asn His Gly Ile Glu 
            100                 105                 110         


Leu His Ser Asp Val Val Glu Tyr Ala Lys Glu Lys Leu Glu Ser Phe 
        115                 120                 125             


Ile Lys Asn Ser Asp Ser Phe Asp Lys Phe Glu Phe Cys Glu Pro Ala 
    130                 135                 140                 


Phe Val Val Gly Asn Cys Leu Gln Ile Ala Ser Asp Ser His Gln Tyr 
145                 150                 155                 160 


Asp Arg Ile Tyr Cys Gly Ala Gly Val Gln Lys Asp His Glu Asn Tyr 
                165                 170                 175     


Met Lys Ile Leu Leu Lys Val Gly Gly Ile Leu Val Met Pro Ile Glu 
            180                 185                 190         


Asp Gln Leu Thr Gln Ile Met Arg Thr Gly Gln Asn Thr Trp Glu Ser 
        195                 200                 205             


Lys Asn Ile Leu Ala Val Ser Phe Ala Pro Leu Val Gln Pro Ser Lys 
    210                 215                 220                 


Asn Asp Asn Gly Lys Pro Asp Ser Val Gly Leu Pro Pro Cys Ala Val 
225                 230                 235                 240 


Arg Asn Leu Gln Asp Leu Ala Arg Ile Tyr Ile Arg Arg Thr Leu Arg 
                245                 250                 255     


Asn Phe Ile Asn Asp Glu Met Gln Ala Lys Gly Ile Pro Gln Arg Ala 
            260                 265                 270         


Pro Pro Lys Arg Lys Arg Lys Arg Val Lys Gln Arg Ile Asn Thr Tyr 
        275                 280                 285             


Val Phe Val Gly Asn Gln Leu Ile Pro Gln Pro Leu Asp Ser Glu Glu 
    290                 295                 300                 


Asp Glu Lys Met Glu Glu Asp Asn Lys Glu Glu Glu Glu Lys Asp His 
305                 310                 315                 320 


Asn Glu Ala Met Lys Pro Glu Glu Pro Pro Gln Asn Leu Leu Arg Glu 
                325                 330                 335     


Lys Ile Met Lys Leu Pro Leu Pro Glu Ser Leu Lys Ala Tyr Leu Thr 
            340                 345                 350         


Tyr Phe Arg Asp Lys 
        355         


<210> 6014
<211> 210
<212> PRT
<213> Homo sapiens

<400> 6014
Met Ser Cys Pro Asn Tyr Cys Ser Gly Asn Ser Asn Ser Gly Ser Leu 
1               5                   10                  15      


Arg Thr Ser Arg His Ile Pro Leu Thr Ser Ile Asp Leu Cys Pro Thr 
            20                  25                  30          


Ser Val Ser Cys Gly Asp Val Leu Tyr Leu Pro Thr Ser Ser Gln Asp 
        35                  40                  45              


His Thr Trp Val Thr Asp Asn Cys Gln Glu Thr Cys Gly Glu Pro Thr 
    50                  55                  60                  


Ser Cys Gln Pro Val His Cys Glu Thr Gly Asn Leu Glu Thr Ser Cys 
65                  70                  75                  80  


Gly Ser Ser Thr Ala Tyr Tyr Val Pro Arg Pro Cys Gln Gly Ser Ser 
                85                  90                  95      


Phe Leu Pro Ala Ser Phe Phe Ser Ser Ser Cys Leu Pro Val Ser Cys 
            100                 105                 110         


Arg Pro Gln Arg Tyr Val Ser Ser Gly Cys Arg Pro Leu Arg Pro Leu 
        115                 120                 125             


Leu Asn Ser Tyr Gln Pro Ile Gly Asp Cys Val Pro Asn Ala Tyr Arg 
    130                 135                 140                 


Pro Gln Phe Cys Leu Ser Lys Ser Cys Gln Pro Gln Asn Leu Leu Thr 
145                 150                 155                 160 


Ser Gly Cys Gln Pro Ser Ser Cys Leu Ala Tyr Arg Pro Gln Ser Leu 
                165                 170                 175     


His Val Val Ser Ser Ser Leu Arg Pro Leu Gly Pro Leu Phe Ser Gly 
            180                 185                 190         


Cys Gln Pro Leu Thr His Val Phe Ser Thr Cys Arg Pro Ser Cys Ser 
        195                 200                 205             


Gly Leu 
    210 


<210> 6015
<211> 201
<212> PRT
<213> Homo sapiens

<400> 6015
Met Ala Ser Gly Asp Asp Ser Pro Ile Phe Glu Asp Asp Glu Ser Pro 
1               5                   10                  15      


Pro Tyr Ser Leu Glu Lys Met Thr Asp Leu Val Ala Val Trp Asp Val 
            20                  25                  30          


Ala Leu Ser Asp Gly Val His Lys Ile Glu Phe Glu His Gly Thr Thr 
        35                  40                  45              


Ser Gly Lys Arg Val Val Tyr Val Asp Gly Lys Glu Glu Ile Arg Lys 
    50                  55                  60                  


Glu Trp Met Phe Lys Leu Val Gly Lys Glu Thr Phe Tyr Val Gly Ala 
65                  70                  75                  80  


Ala Lys Thr Lys Ala Thr Ile Asn Ile Asp Ala Ile Ser Gly Phe Ala 
                85                  90                  95      


Tyr Glu Tyr Thr Leu Glu Ile Asn Gly Lys Ser Leu Lys Lys Tyr Met 
            100                 105                 110         


Glu Asp Arg Ser Lys Thr Thr Asn Thr Trp Val Leu His Met Asp Gly 
        115                 120                 125             


Glu Asn Phe Arg Ile Val Leu Glu Lys Asp Ala Met Asp Val Trp Cys 
    130                 135                 140                 


Asn Gly Lys Lys Leu Glu Thr Ala Gly Glu Phe Val Asp Asp Gly Thr 
145                 150                 155                 160 


Glu Thr His Phe Ser Ile Gly Asn His Asp Cys Tyr Ile Lys Ala Val 
                165                 170                 175     


Ser Ser Gly Lys Arg Lys Glu Gly Ile Ile His Thr Leu Ile Val Asp 
            180                 185                 190         


Asn Arg Glu Ile Pro Glu Ile Ala Ser 
        195                 200     


<210> 6016
<211> 1129
<212> PRT
<213> Homo sapiens

<400> 6016
Met Pro Ala Thr Arg Lys Pro Met Arg Tyr Gly His Thr Glu Gly His 
1               5                   10                  15      


Thr Glu Val Cys Phe Asp Asp Ser Gly Ser Phe Ile Val Thr Cys Gly 
            20                  25                  30          


Ser Asp Gly Asp Val Arg Ile Trp Glu Asp Leu Asp Asp Asp Asp Pro 
        35                  40                  45              


Lys Phe Ile Asn Val Gly Glu Lys Ala Tyr Ser Cys Ala Leu Lys Ser 
    50                  55                  60                  


Gly Lys Leu Val Thr Ala Val Ser Asn Asn Thr Ile Gln Val His Thr 
65                  70                  75                  80  


Phe Pro Glu Gly Val Pro Asp Gly Ile Leu Thr Arg Phe Thr Thr Asn 
                85                  90                  95      


Ala Asn His Val Val Phe Asn Gly Asp Gly Thr Lys Ile Ala Ala Gly 
            100                 105                 110         


Ser Ser Asp Phe Leu Val Lys Ile Val Asp Val Met Asp Ser Ser Gln 
        115                 120                 125             


Gln Lys Thr Phe Arg Gly His Asp Ala Pro Val Leu Ser Leu Ser Phe 
    130                 135                 140                 


Asp Pro Lys Asp Ile Phe Leu Ala Ser Ala Ser Cys Asp Gly Ser Val 
145                 150                 155                 160 


Arg Val Trp Gln Ile Ser Asp Gln Thr Cys Ala Ile Ser Trp Pro Leu 
                165                 170                 175     


Leu Gln Lys Cys Asn Asp Val Ile Asn Ala Lys Ser Ile Cys Arg Leu 
            180                 185                 190         


Ala Trp Gln Pro Lys Ser Gly Lys Leu Leu Ala Ile Pro Val Glu Lys 
        195                 200                 205             


Ser Val Lys Leu Tyr Arg Arg Glu Ser Trp Ser His Gln Phe Asp Leu 
    210                 215                 220                 


Ser Asp Asn Phe Ile Ser Gln Thr Leu Asn Ile Val Thr Trp Ser Pro 
225                 230                 235                 240 


Cys Gly Gln Tyr Leu Ala Ala Gly Ser Ile Asn Gly Leu Ile Ile Val 
                245                 250                 255     


Trp Asn Val Glu Thr Lys Asp Cys Met Glu Arg Val Lys His Glu Lys 
            260                 265                 270         


Gly Tyr Ala Ile Cys Gly Leu Ala Trp His Pro Thr Cys Gly Arg Ile 
        275                 280                 285             


Ser Tyr Thr Asp Ala Glu Gly Asn Leu Gly Leu Leu Glu Asn Val Cys 
    290                 295                 300                 


Asp Pro Ser Gly Lys Thr Ser Ser Ser Lys Val Ser Ser Arg Val Glu 
305                 310                 315                 320 


Lys Asp Tyr Asn Asp Leu Phe Asp Gly Asp Asp Met Ser Asn Ala Gly 
                325                 330                 335     


Asp Phe Leu Asn Asp Asn Ala Val Glu Ile Pro Ser Phe Ser Lys Gly 
            340                 345                 350         


Ile Ile Asn Asp Asp Glu Asp Asp Glu Asp Leu Met Met Ala Ser Gly 
        355                 360                 365             


Arg Pro Arg Gln Arg Ser His Ile Leu Glu Asp Asp Glu Asn Ser Val 
    370                 375                 380                 


Asp Ile Ser Met Leu Lys Thr Gly Ser Ser Leu Leu Lys Glu Glu Glu 
385                 390                 395                 400 


Glu Asp Gly Gln Glu Gly Ser Ile His Asn Leu Pro Leu Val Thr Ser 
                405                 410                 415     


Gln Arg Pro Phe Tyr Asp Gly Pro Met Pro Thr Pro Arg Gln Lys Pro 
            420                 425                 430         


Phe Gln Ser Gly Ser Thr Pro Leu His Leu Thr His Arg Phe Met Val 
        435                 440                 445             


Trp Asn Ser Ile Gly Ile Ile Arg Cys Tyr Asn Asp Glu Gln Asp Asn 
    450                 455                 460                 


Ala Ile Asp Val Glu Phe His Asp Thr Ser Ile His His Ala Thr His 
465                 470                 475                 480 


Leu Ser Asn Thr Leu Asn Tyr Thr Ile Ala Asp Leu Ser His Glu Ala 
                485                 490                 495     


Ile Leu Leu Ala Cys Glu Ser Thr Asp Glu Leu Ala Ser Lys Leu His 
            500                 505                 510         


Cys Leu His Phe Ser Ser Trp Asp Ser Ser Lys Glu Trp Ile Ile Asp 
        515                 520                 525             


Leu Pro Gln Asn Glu Asp Ile Glu Ala Ile Cys Leu Gly Gln Gly Trp 
    530                 535                 540                 


Ala Ala Ala Ala Thr Ser Ala Leu Leu Leu Arg Leu Phe Thr Ile Gly 
545                 550                 555                 560 


Gly Val Gln Lys Glu Val Phe Ser Leu Ala Gly Pro Val Val Ser Met 
                565                 570                 575     


Ala Gly His Gly Glu Gln Leu Phe Ile Val Tyr His Arg Gly Thr Gly 
            580                 585                 590         


Phe Asp Gly Asp Gln Cys Leu Gly Val Gln Leu Leu Glu Leu Gly Lys 
        595                 600                 605             


Lys Lys Lys Gln Ile Leu His Gly Asp Pro Leu Pro Leu Thr Arg Lys 
    610                 615                 620                 


Ser Tyr Leu Ala Trp Ile Gly Phe Ser Ala Glu Gly Thr Pro Cys Tyr 
625                 630                 635                 640 


Val Asp Ser Glu Gly Ile Val Arg Met Leu Asn Arg Gly Leu Gly Asn 
                645                 650                 655     


Thr Trp Thr Pro Ile Cys Asn Thr Arg Glu His Cys Lys Gly Lys Ser 
            660                 665                 670         


Asp His Tyr Trp Val Val Gly Ile His Glu Asn Pro Gln Gln Leu Arg 
        675                 680                 685             


Cys Ile Pro Cys Lys Gly Ser Arg Phe Pro Pro Thr Leu Pro Arg Pro 
    690                 695                 700                 


Ala Val Ala Ile Leu Ser Phe Lys Leu Pro Tyr Cys Gln Ile Ala Thr 
705                 710                 715                 720 


Glu Lys Gly Gln Met Glu Glu Gln Phe Trp Arg Ser Val Ile Phe His 
                725                 730                 735     


Asn His Leu Asp Tyr Leu Ala Lys Asn Gly Tyr Glu Tyr Glu Glu Ser 
            740                 745                 750         


Thr Lys Asn Gln Ala Thr Lys Glu Gln Gln Glu Leu Leu Met Lys Met 
        755                 760                 765             


Leu Ala Leu Ser Cys Lys Leu Glu Arg Glu Phe Arg Cys Val Glu Leu 
    770                 775                 780                 


Ala Asp Leu Met Thr Gln Asn Ala Val Asn Leu Ala Ile Lys Tyr Ala 
785                 790                 795                 800 


Ser Arg Ser Arg Lys Leu Ile Leu Ala Gln Lys Leu Ser Glu Leu Ala 
                805                 810                 815     


Val Glu Lys Ala Ala Glu Leu Thr Ala Thr Gln Val Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Glu Asp Phe Arg Lys Lys Leu Asn Ala Gly Tyr Ser Asn Thr 
        835                 840                 845             


Ala Thr Glu Trp Ser Gln Pro Arg Phe Arg Asn Gln Val Glu Glu Asp 
    850                 855                 860                 


Ala Glu Asp Ser Gly Glu Ala Asp Asp Glu Glu Lys Pro Glu Ile His 
865                 870                 875                 880 


Lys Pro Gly Gln Asn Ser Phe Ser Lys Ser Thr Asn Ser Ser Asp Val 
                885                 890                 895     


Ser Ala Lys Ser Gly Ala Val Thr Phe Ser Ser Gln Gly Arg Val Asn 
            900                 905                 910         


Pro Phe Lys Val Ser Ala Ser Ser Lys Glu Pro Ala Met Ser Met Asn 
        915                 920                 925             


Ser Ala Arg Ser Thr Asn Ile Leu Asp Asn Met Gly Lys Ser Ser Lys 
    930                 935                 940                 


Lys Ser Thr Ala Leu Ser Arg Thr Thr Asn Asn Glu Lys Ser Pro Ile 
945                 950                 955                 960 


Ile Lys Pro Leu Ile Pro Lys Pro Lys Pro Lys Gln Ala Ser Ala Ala 
                965                 970                 975     


Ser Tyr Phe Gln Lys Arg Asn Ser Gln Thr Asn Lys Thr Glu Glu Val 
            980                 985                 990         


Lys Glu Glu Asn Leu Lys Asn Val  Leu Ser Glu Thr Pro  Ala Ile Cys 
        995                 1000                 1005             


Pro Pro  Gln Asn Thr Glu Asn  Gln Arg Pro Lys Thr  Gly Phe Gln 
    1010                 1015                 1020             


Met Trp  Leu Glu Glu Asn Arg  Ser Asn Ile Leu Ser  Asp Asn Pro 
    1025                 1030                 1035             


Asp Phe  Ser Asp Glu Ala Asp  Ile Ile Lys Glu Gly  Met Ile Arg 
    1040                 1045                 1050             


Phe Arg  Val Leu Ser Thr Glu  Glu Arg Lys Val Trp  Ala Asn Lys 
    1055                 1060                 1065             


Ala Lys  Gly Glu Thr Ala Ser  Glu Gly Thr Glu Ala  Lys Lys Arg 
    1070                 1075                 1080             


Lys Arg  Val Val Asp Glu Ser  Asp Glu Thr Glu Asn  Gln Glu Glu 
    1085                 1090                 1095             


Lys Ala  Lys Glu Asn Leu Asn  Leu Ser Lys Lys Gln  Lys Pro Leu 
    1100                 1105                 1110             


Asp Phe  Ser Thr Asn Gln Lys  Leu Ser Ala Phe Ala  Phe Lys Gln 
    1115                 1120                 1125             


Glu 
    


<210> 6017
<211> 491
<212> PRT
<213> Homo sapiens

<400> 6017
Ser Gly Ser Ser His Ser Phe Pro Gly Ser Leu Glu Val Thr Ala Leu 
1               5                   10                  15      


Met Thr Thr Trp Ser Ser Leu Gln Gly Ser His Val Ser Lys Arg Ala 
            20                  25                  30          


Leu Ala Tyr Ala Leu Val Val Thr Asn Cys Gln Glu Arg Ile Gln His 
        35                  40                  45              


Trp Lys Lys Val Asp Asn Asp Tyr Asn Ala Leu Arg Glu Arg Leu Ser 
    50                  55                  60                  


Thr Leu Pro Asp Lys Leu Ser Tyr Asn Ile Met Val Pro Phe Gly Pro 
65                  70                  75                  80  


Phe Ala Phe Met Pro Gly Lys Leu Val His Thr Asn Glu Val Thr Val 
                85                  90                  95      


Leu Leu Gly Asp Asn Trp Phe Ala Lys Cys Ser Ala Lys Gln Ala Val 
            100                 105                 110         


Gly Leu Val Glu His Arg Lys Glu His Val Arg Lys Thr Ile Asp Asp 
        115                 120                 125             


Leu Lys Lys Val Met Lys Asn Phe Glu Ser Arg Val Glu Phe Thr Glu 
    130                 135                 140                 


Asp Leu Gln Lys Met Ser Asp Ala Ala Gly Asp Ile Val Asp Ile Arg 
145                 150                 155                 160 


Glu Glu Ile Lys Cys Asp Phe Glu Phe Lys Ala Lys His Arg Ile Ala 
                165                 170                 175     


His Lys Pro His Ser Lys Pro Lys Thr Ser Asp Ile Phe Glu Ala Asp 
            180                 185                 190         


Ile Ala Asn Asp Val Lys Ser Lys Asp Leu Leu Ala Asp Lys Glu Leu 
        195                 200                 205             


Trp Ala Arg Leu Glu Glu Leu Glu Arg Gln Glu Glu Leu Leu Gly Glu 
    210                 215                 220                 


Leu Asp Ser Lys Pro Asp Thr Val Ile Ala Asn Gly Glu Asp Thr Thr 
225                 230                 235                 240 


Ser Ser Glu Glu Glu Lys Glu Asp Arg Asn Thr Asn Val Asn Ala Met 
                245                 250                 255     


His Gln Val Thr Asp Ser His Thr Pro Cys His Lys Asp Val Ala Ser 
            260                 265                 270         


Ser Glu Pro Phe Ser Gly Gln Val Asn Ser Gln Leu Asn Cys Ser Val 
        275                 280                 285             


Asn Gly Ser Ser Ser Tyr His Ser Asp Asp Asp Asp Asp Asp Asp Asp 
    290                 295                 300                 


Asp Asp Asp Asp Asp Asn Ile Asp Asp Asp Asp Gly Asp Asn Asp His 
305                 310                 315                 320 


Glu Ala Leu Gly Val Gly Asp Asn Ser Ile Pro Thr Ile Tyr Phe Ser 
                325                 330                 335     


His Thr Val Glu Pro Lys Arg Val Arg Ile Asn Thr Gly Lys Asn Thr 
            340                 345                 350         


Thr Leu Lys Phe Ser Glu Lys Lys Glu Glu Ala Lys Arg Lys Arg Lys 
        355                 360                 365             


Asn Ser Thr Gly Ser Gly His Ser Ala Gln Glu Leu Pro Thr Ile Arg 
    370                 375                 380                 


Thr Pro Ala Asp Ile Tyr Arg Ala Phe Val Asp Val Val Asn Gly Glu 
385                 390                 395                 400 


Tyr Val Pro Arg Lys Ser Ile Leu Lys Ser Arg Ser Arg Glu Asn Ser 
                405                 410                 415     


Val Cys Ser Asp Thr Ser Glu Ser Ser Ala Ala Glu Phe Asp Asp Arg 
            420                 425                 430         


Arg Gly Val Leu Arg Ser Ile Ser Cys Glu Glu Ala Thr Cys Ser Asp 
        435                 440                 445             


Thr Ser Glu Ser Ile Leu Glu Glu Glu Pro Gln Glu Asn Gln Lys Lys 
    450                 455                 460                 


Leu Leu Pro Leu Ser Val Thr Pro Glu Val Leu Arg Leu Val Gly Tyr 
465                 470                 475                 480 


Ser Arg Asn Leu Ala Pro Leu Asn Val Ile Leu 
                485                 490     


<210> 6018
<211> 326
<212> PRT
<213> Homo sapiens

<400> 6018
Met Leu Leu Ser Lys Phe Gly Ser Leu Ala His Leu Cys Gly Pro Gly 
1               5                   10                  15      


Gly Val Asp His Leu Pro Val Lys Ile Leu Gln Pro Ala Lys Ala Asp 
            20                  25                  30          


Lys Glu Ser Phe Glu Lys Ala Tyr Gln Val Gly Ala Val Leu Gly Ser 
        35                  40                  45              


Gly Gly Phe Gly Thr Val Tyr Ala Gly Ser Arg Ile Ala Asp Gly Leu 
    50                  55                  60                  


Pro Val Ala Val Lys His Val Val Lys Glu Arg Val Thr Glu Trp Gly 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Thr Val Pro Leu Glu Val Val Leu Leu Arg Lys 
                85                  90                  95      


Val Gly Ala Ala Gly Gly Ala Arg Gly Val Ile Arg Leu Leu Asp Trp 
            100                 105                 110         


Phe Glu Arg Pro Asp Gly Phe Leu Leu Val Leu Glu Arg Pro Glu Pro 
        115                 120                 125             


Ala Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Asp Glu 
    130                 135                 140                 


Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu Ala Ala Val Arg His 
145                 150                 155                 160 


Cys His Ser Cys Gly Val Val His Arg Asp Ile Lys Asp Glu Asn Leu 
                165                 170                 175     


Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser 
            180                 185                 190         


Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg 
        195                 200                 205             


Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg 
    210                 215                 220                 


Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu Tyr Asp Met Val Cys 
225                 230                 235                 240 


Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile Leu Arg Gly Arg Leu 
                245                 250                 255     


Leu Phe Arg Arg Arg Val Ser Pro Glu Cys Gln Gln Leu Ile Arg Trp 
            260                 265                 270         


Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser Leu Asp Gln Ile Ala 
        275                 280                 285             


Ala His Pro Trp Met Leu Gly Ala Asp Gly Gly Val Pro Glu Ser Cys 
    290                 295                 300                 


Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp Asp Val Ala Ser Thr Thr 
305                 310                 315                 320 


Ser Ser Ser Glu Ser Leu 
                325     


<210> 6019
<211> 959
<212> PRT
<213> Homo sapiens

<400> 6019
Met Ala Ala Ser Thr Gly Tyr Val Arg Leu Trp Gly Ala Ala Arg Cys 
1               5                   10                  15      


Trp Val Leu Arg Arg Pro Met Leu Ala Ala Ala Gly Gly Arg Val Pro 
            20                  25                  30          


Thr Ala Ala Gly Ala Trp Leu Leu Arg Gly Gln Arg Thr Cys Asp Ala 
        35                  40                  45              


Ser Pro Pro Trp Ala Leu Trp Gly Arg Gly Pro Ala Ile Gly Gly Gln 
    50                  55                  60                  


Trp Arg Gly Phe Trp Glu Ala Ser Ser Arg Gly Gly Gly Ala Phe Ser 
65                  70                  75                  80  


Gly Gly Glu Asp Ala Ser Glu Gly Gly Ala Glu Glu Gly Ala Gly Gly 
                85                  90                  95      


Ala Gly Gly Ser Ala Gly Ala Gly Glu Gly Pro Val Ile Thr Ala Leu 
            100                 105                 110         


Thr Pro Met Thr Ile Pro Asp Val Phe Pro His Leu Pro Leu Ile Ala 
        115                 120                 125             


Ile Thr Arg Asn Pro Val Phe Pro Arg Phe Ile Lys Ile Ile Glu Val 
    130                 135                 140                 


Lys Asn Lys Lys Leu Val Glu Leu Leu Arg Arg Lys Val Arg Leu Ala 
145                 150                 155                 160 


Gln Pro Tyr Val Gly Val Phe Leu Lys Arg Asp Asp Ser Asn Glu Ser 
                165                 170                 175     


Asp Val Val Glu Ser Leu Asp Glu Ile Tyr His Thr Gly Thr Phe Ala 
            180                 185                 190         


Gln Ile His Glu Met Gln Asp Leu Gly Asp Lys Leu Arg Met Ile Val 
        195                 200                 205             


Met Gly His Arg Arg Val His Ile Ser Arg Gln Leu Glu Val Glu Pro 
    210                 215                 220                 


Glu Glu Pro Glu Ala Glu Asn Lys His Lys Pro Arg Arg Lys Ser Lys 
225                 230                 235                 240 


Arg Gly Lys Lys Glu Ala Glu Asp Glu Leu Ser Ala Arg His Pro Ala 
                245                 250                 255     


Glu Leu Ala Met Glu Pro Thr Pro Glu Leu Pro Ala Glu Val Leu Met 
            260                 265                 270         


Val Glu Val Glu Asn Val Val His Glu Asp Phe Gln Val Thr Glu Glu 
        275                 280                 285             


Val Lys Ala Leu Thr Ala Glu Ile Val Lys Thr Ile Arg Asp Ile Ile 
    290                 295                 300                 


Ala Leu Asn Pro Leu Tyr Arg Glu Ser Val Leu Gln Met Met Gln Ala 
305                 310                 315                 320 


Gly Gln Arg Val Val Asp Asn Pro Ile Tyr Leu Ser Asp Met Gly Ala 
                325                 330                 335     


Ala Leu Thr Gly Ala Glu Ser His Glu Leu Gln Asp Val Leu Glu Glu 
            340                 345                 350         


Thr Asn Ile Pro Lys Arg Leu Tyr Lys Ala Leu Ser Leu Leu Lys Lys 
        355                 360                 365             


Glu Phe Glu Leu Ser Lys Leu Gln Gln Arg Leu Gly Arg Glu Val Glu 
    370                 375                 380                 


Glu Lys Ile Lys Gln Thr His Arg Lys Tyr Leu Leu Gln Glu Gln Leu 
385                 390                 395                 400 


Lys Ile Ile Lys Lys Glu Leu Gly Leu Glu Lys Asp Asp Lys Asp Ala 
                405                 410                 415     


Ile Glu Glu Lys Phe Arg Glu Arg Leu Lys Glu Leu Val Val Pro Lys 
            420                 425                 430         


His Val Met Asp Val Val Asp Glu Glu Leu Ser Lys Leu Gly Leu Leu 
        435                 440                 445             


Asp Asn His Ser Ser Glu Phe Asn Val Thr Arg Asn Tyr Leu Asp Trp 
    450                 455                 460                 


Leu Thr Ser Ile Pro Trp Gly Lys Tyr Ser Asn Glu Asn Leu Asp Leu 
465                 470                 475                 480 


Ala Arg Ala Gln Ala Val Leu Glu Glu Asp His Tyr Gly Met Glu Asp 
                485                 490                 495     


Val Lys Lys Arg Ile Leu Glu Phe Ile Ala Val Ser Gln Leu Arg Gly 
            500                 505                 510         


Ser Thr Gln Gly Lys Ile Leu Cys Phe Tyr Gly Pro Pro Gly Val Gly 
        515                 520                 525             


Lys Thr Ser Ile Ala Arg Ser Ile Ala Arg Ala Leu Asn Arg Glu Tyr 
    530                 535                 540                 


Phe Arg Phe Ser Val Gly Gly Met Thr Asp Val Ala Glu Ile Lys Gly 
545                 550                 555                 560 


His Arg Arg Thr Tyr Val Gly Ala Met Pro Gly Lys Ile Ile Gln Cys 
                565                 570                 575     


Leu Lys Lys Thr Lys Thr Glu Asn Pro Leu Ile Leu Ile Asp Glu Val 
            580                 585                 590         


Asp Lys Ile Gly Arg Gly Tyr Gln Gly Asp Pro Ser Ser Ala Leu Leu 
        595                 600                 605             


Glu Leu Leu Asp Pro Glu Gln Asn Ala Asn Phe Leu Asp His Tyr Leu 
    610                 615                 620                 


Asp Val Pro Val Asp Leu Ser Lys Val Leu Phe Ile Cys Thr Ala Asn 
625                 630                 635                 640 


Val Thr Asp Thr Ile Pro Glu Pro Leu Arg Asp Arg Met Glu Met Ile 
                645                 650                 655     


Asn Val Ser Gly Tyr Val Ala Gln Glu Lys Leu Ala Ile Ala Glu Arg 
            660                 665                 670         


Tyr Leu Val Pro Gln Ala Arg Ala Leu Cys Gly Leu Asp Glu Ser Lys 
        675                 680                 685             


Ala Lys Leu Ser Ser Asp Val Leu Thr Leu Leu Ile Lys Gln Tyr Cys 
    690                 695                 700                 


Arg Glu Ser Gly Val Arg Asn Leu Gln Lys Gln Val Glu Lys Val Leu 
705                 710                 715                 720 


Arg Lys Ser Ala Tyr Lys Ile Val Ser Gly Glu Ala Glu Ser Val Glu 
                725                 730                 735     


Val Thr Pro Glu Asn Leu Gln Asp Phe Val Gly Lys Pro Val Phe Thr 
            740                 745                 750         


Val Glu Arg Met Tyr Asp Val Thr Pro Pro Gly Val Val Met Gly Leu 
        755                 760                 765             


Ala Trp Thr Ala Met Gly Gly Ser Thr Leu Phe Val Glu Thr Ser Leu 
    770                 775                 780                 


Arg Arg Pro Gln Asp Lys Asp Ala Lys Gly Asp Lys Asp Gly Ser Leu 
785                 790                 795                 800 


Glu Val Thr Gly Gln Leu Gly Glu Val Met Lys Glu Ser Ala Arg Ile 
                805                 810                 815     


Ala Tyr Thr Phe Ala Arg Ala Phe Leu Met Gln His Ala Pro Ala Asn 
            820                 825                 830         


Asp Tyr Leu Val Thr Ser His Ile His Leu His Val Pro Glu Gly Ala 
        835                 840                 845             


Thr Pro Lys Asp Gly Pro Ser Ala Gly Cys Thr Ile Val Thr Ala Leu 
    850                 855                 860                 


Leu Ser Leu Ala Met Gly Arg Pro Val Arg Gln Asn Leu Ala Met Thr 
865                 870                 875                 880 


Gly Glu Val Ser Leu Thr Gly Lys Ile Leu Pro Val Gly Gly Ile Lys 
                885                 890                 895     


Glu Lys Thr Ile Ala Ala Lys Arg Ala Gly Val Thr Cys Ile Val Leu 
            900                 905                 910         


Pro Ala Glu Asn Lys Lys Asp Phe Tyr Asp Leu Ala Ala Phe Ile Thr 
        915                 920                 925             


Glu Gly Leu Glu Val His Phe Val Glu His Tyr Arg Glu Ile Phe Asp 
    930                 935                 940                 


Ile Ala Phe Pro Asp Glu Gln Ala Glu Ala Leu Ala Val Glu Arg 
945                 950                 955                 


<210> 6020
<211> 400
<212> PRT
<213> Homo sapiens

<400> 6020
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Val Met Asn 
            180                 185                 190         


His Gln His Gln Gln Gln Met Ala Pro Ser Thr Leu Ser Gln Gln Asn 
        195                 200                 205             


His Pro Thr Gln Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala 
    210                 215                 220                 


Leu Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile 
225                 230                 235                 240 


Gln Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg 
                245                 250                 255     


Gln Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Ala Glu Thr Leu 
            260                 265                 270         


Ala Pro Val Gln Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met 
        275                 280                 285             


Arg Ser Ile Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro 
    290                 295                 300                 


Tyr His Ser Arg Glu Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys 
305                 310                 315                 320 


Tyr Ser Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu 
                325                 330                 335     


Met Asp Thr Gly Glu Asn Ala Gly Gln Thr Pro Met Asn Ile Asn Pro 
            340                 345                 350         


Gln Gln Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn 
        355                 360                 365             


Val Asp Leu Gly Thr Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn 
    370                 375                 380                 


Asp Val Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 
385                 390                 395                 400 


<210> 6021
<211> 874
<212> PRT
<213> Homo sapiens

<400> 6021
Met Glu Val Leu Arg Glu Lys Val Glu Glu Glu Glu Glu Ala Glu Arg 
1               5                   10                  15      


Glu Glu Ala Ala Glu Trp Ala Glu Trp Ala Arg Met Glu Lys Met Met 
            20                  25                  30          


Arg Pro Val Glu Val Arg Lys Glu Glu Ile Thr Leu Lys Gln Glu Thr 
        35                  40                  45              


Leu Arg Asp Leu Glu Lys Lys Leu Ser Glu Ile Gln Ile Thr Val Ser 
    50                  55                  60                  


Ala Glu Leu Pro Ala Phe Thr Lys Asp Thr Ile Asp Ile Ser Lys Leu 
65                  70                  75                  80  


Pro Ile Ser Tyr Lys Thr Asn Thr Pro Lys Glu Glu His Leu Leu Gln 
                85                  90                  95      


Val Ala Asp Asn Phe Ser Arg Gln Tyr Ser His Leu Cys Pro Asp Arg 
            100                 105                 110         


Val Pro Leu Phe Leu His Pro Leu Asn Glu Cys Glu Val Pro Lys Phe 
        115                 120                 125             


Val Ser Thr Thr Leu Arg Pro Thr Leu Met Pro Tyr Pro Glu Leu Tyr 
    130                 135                 140                 


Asn Trp Asp Ser Cys Ala Gln Phe Val Ser Asp Phe Leu Thr Met Val 
145                 150                 155                 160 


Pro Leu Pro Asp Pro Leu Lys Pro Pro Ser His Leu Tyr Ser Ser Thr 
                165                 170                 175     


Thr Val Leu Lys Tyr Gln Lys Gly Asn Cys Phe Asp Phe Ser Thr Leu 
            180                 185                 190         


Leu Cys Ser Met Leu Ile Gly Ser Gly Tyr Asp Ala Tyr Cys Val Asn 
        195                 200                 205             


Gly Tyr Gly Ser Leu Asp Leu Cys His Met Asp Leu Thr Arg Glu Val 
    210                 215                 220                 


Cys Pro Leu Thr Val Lys Pro Lys Glu Thr Ile Lys Lys Glu Glu Lys 
225                 230                 235                 240 


Val Leu Pro Lys Lys Tyr Thr Ile Lys Pro Pro Arg Asp Leu Cys Ser 
                245                 250                 255     


Arg Phe Glu Gln Glu Gln Glu Val Lys Lys Gln Gln Glu Ile Arg Ala 
            260                 265                 270         


Gln Glu Lys Lys Arg Leu Arg Glu Glu Glu Glu Arg Leu Met Glu Ala 
        275                 280                 285             


Glu Lys Ala Lys Pro Asp Ala Leu His Gly Leu Arg Val His Ser Trp 
    290                 295                 300                 


Val Leu Val Leu Ser Gly Lys Arg Glu Val Pro Glu Asn Phe Phe Ile 
305                 310                 315                 320 


Asp Pro Phe Thr Gly His Ser Tyr Ser Thr Gln Asp Glu His Phe Leu 
                325                 330                 335     


Gly Ile Glu Ser Leu Trp Asn His Lys Asn Tyr Trp Ile Asn Met Gln 
            340                 345                 350         


Asp Cys Trp Asn Cys Cys Lys Asp Leu Ile Phe Asp Leu Gly Asp Pro 
        355                 360                 365             


Val Arg Trp Glu Tyr Met Leu Leu Gly Thr Asp Lys Ser Gln Leu Ser 
    370                 375                 380                 


Leu Thr Glu Glu Asp Asp Ser Gly Ile Asn Asp Glu Asp Asp Val Glu 
385                 390                 395                 400 


Asn Leu Gly Lys Glu Asp Glu Asp Lys Ser Phe Asp Met Pro His Ser 
                405                 410                 415     


Trp Val Glu Gln Ile Glu Ile Ser Pro Glu Ala Phe Glu Thr Arg Cys 
            420                 425                 430         


Pro Asn Gly Lys Lys Val Ile Gln Tyr Lys Arg Ala Lys Leu Glu Lys 
        435                 440                 445             


Trp Ala Pro Tyr Leu Asn Ser Asn Gly Leu Val Ser Arg Leu Thr Thr 
    450                 455                 460                 


Tyr Glu Asp Leu Gln Cys Thr Asn Ile Leu Glu Ile Lys Glu Trp Tyr 
465                 470                 475                 480 


Gln Asn Arg Glu Asp Met Leu Glu Leu Lys His Ile Asn Lys Thr Thr 
                485                 490                 495     


Asp Leu Lys Thr Asp Tyr Phe Lys Pro Gly His Pro Gln Ala Leu Arg 
            500                 505                 510         


Val His Ser Tyr Lys Ser Met Gln Pro Glu Met Asp Arg Val Ile Glu 
        515                 520                 525             


Phe Tyr Glu Thr Ala Arg Val Asp Gly Leu Met Lys Arg Glu Glu Thr 
    530                 535                 540                 


Pro Arg Thr Met Thr Glu Tyr Tyr Gln Gly Arg Pro Asp Phe Leu Ser 
545                 550                 555                 560 


Tyr Arg His Ala Ser Phe Gly Pro Arg Val Lys Lys Leu Thr Leu Ser 
                565                 570                 575     


Ser Ala Glu Ser Asn Pro Arg Pro Ile Val Lys Ile Thr Glu Arg Phe 
            580                 585                 590         


Phe Arg Asn Pro Ala Lys Pro Ala Glu Glu Asp Val Ala Glu Arg Val 
        595                 600                 605             


Phe Leu Val Ala Glu Glu Arg Ile Gln Leu Arg Tyr His Cys Arg Glu 
    610                 615                 620                 


Asp His Ile Thr Ala Ser Lys Arg Glu Phe Leu Arg Arg Thr Glu Val 
625                 630                 635                 640 


Asp Ser Lys Gly Asn Lys Ile Ile Met Thr Pro Asp Met Cys Ile Ser 
                645                 650                 655     


Phe Glu Val Glu Pro Met Glu His Thr Lys Lys Leu Leu Tyr Gln Tyr 
            660                 665                 670         


Glu Ala Met Met His Leu Lys Arg Glu Glu Lys Leu Ser Arg His Gln 
        675                 680                 685             


Val Trp Glu Ser Glu Leu Glu Val Leu Glu Ile Leu Lys Leu Arg Glu 
    690                 695                 700                 


Glu Glu Glu Ala Ala His Thr Leu Thr Ile Ser Ile Tyr Asp Thr Lys 
705                 710                 715                 720 


Arg Asn Glu Lys Ser Lys Glu Tyr Arg Glu Ala Met Glu Arg Met Met 
                725                 730                 735     


His Glu Glu His Leu Arg Gln Val Glu Thr Gln Leu Asp Tyr Leu Ala 
            740                 745                 750         


Pro Phe Leu Ala Gln Leu Pro Pro Gly Glu Lys Leu Thr Cys Trp Gln 
        755                 760                 765             


Ala Val Arg Leu Lys Asp Glu Cys Leu Ser Asp Phe Lys Gln Arg Leu 
    770                 775                 780                 


Ile Asn Lys Ala Asn Leu Ile Gln Ala Arg Phe Glu Lys Glu Thr Gln 
785                 790                 795                 800 


Glu Leu Gln Lys Lys Gln Gln Trp Tyr Gln Glu Asn Gln Val Thr Leu 
                805                 810                 815     


Thr Pro Glu Asp Glu Asp Leu Tyr Leu Ser Tyr Cys Ser Gln Ala Met 
            820                 825                 830         


Phe Arg Ile Arg Ile Leu Glu Gln Arg Leu Asn Arg His Lys Glu Leu 
        835                 840                 845             


Ala Pro Leu Lys Tyr Leu Ala Leu Glu Glu Lys Leu Tyr Lys Asp Pro 
    850                 855                 860                 


Arg Leu Gly Glu Leu Gln Lys Ile Phe Ala 
865                 870                 


<210> 6022
<211> 616
<212> PRT
<213> Homo sapiens

<400> 6022
Met Asp Val Met Leu Glu Asn Tyr Cys His Leu Ile Ser Val Gly Cys 
1               5                   10                  15      


His Met Thr Lys Pro Asp Val Ile Leu Lys Leu Glu Arg Gly Glu Glu 
            20                  25                  30          


Pro Trp Thr Ser Phe Ala Gly His Thr Cys Leu Glu Glu Asn Trp Lys 
        35                  40                  45              


Ala Glu Asp Phe Leu Val Lys Phe Lys Glu His Gln Glu Lys Tyr Ser 
    50                  55                  60                  


Arg Ser Val Val Ser Ile Asn His Lys Lys Leu Val Lys Glu Lys Ser 
65                  70                  75                  80  


Lys Ile Tyr Glu Lys Thr Phe Thr Leu Gly Lys Asn Pro Val Asn Ser 
                85                  90                  95      


Lys Asn Leu Pro Pro Glu Tyr Asp Thr His Gly Arg Ile Leu Lys Asn 
            100                 105                 110         


Val Ser Glu Leu Ile Ile Ser Asn Leu Asn Pro Ala Arg Lys Arg Leu 
        115                 120                 125             


Ser Glu Tyr Asn Gly Tyr Gly Lys Ser Leu Leu Ser Thr Lys Gln Glu 
    130                 135                 140                 


Thr Thr His Pro Glu Val Lys Ser His Asn Gln Ser Ala Arg Ala Phe 
145                 150                 155                 160 


Ser His Asn Glu Val Leu Met Gln Tyr Gln Lys Thr Glu Thr Pro Ala 
                165                 170                 175     


Gln Ser Phe Gly Tyr Asn Asp Cys Glu Lys Ser Phe Leu Gln Arg Gly 
            180                 185                 190         


Gly Leu Ile Thr His Ser Arg Pro Tyr Lys Gly Glu Asn Pro Ser Val 
        195                 200                 205             


Tyr Asn Lys Lys Arg Arg Ala Thr Asn Ile Glu Lys Lys His Thr Cys 
    210                 215                 220                 


Asn Glu Cys Gly Lys Ser Phe Cys Arg Lys Ser Val Leu Ile Leu His 
225                 230                 235                 240 


Gln Gly Ile His Ser Glu Glu Lys Pro Tyr Gln Cys His Gln Cys Gly 
                245                 250                 255     


Asn Ala Phe Arg Arg Lys Ser Tyr Leu Ile Asp His Gln Arg Thr His 
            260                 265                 270         


Thr Gly Glu Lys Pro Phe Val Cys Asn Glu Cys Gly Lys Ser Phe Arg 
        275                 280                 285             


Leu Lys Thr Ala Leu Thr Asp His Gln Arg Thr His Thr Gly Glu Lys 
    290                 295                 300                 


Ser Tyr Glu Cys Leu Gln Cys Arg Asn Ala Phe Arg Leu Lys Ser His 
305                 310                 315                 320 


Leu Ile Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys 
                325                 330                 335     


Asn Asp Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu Ser Leu His 
            340                 345                 350         


Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Lys Glu Cys Gly 
        355                 360                 365             


Lys Ser Phe His Gln Lys Ala Asn Leu Thr Val His Gln Arg Thr His 
    370                 375                 380                 


Thr Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Ser 
385                 390                 395                 400 


Gln Lys Thr Thr Leu Ala Leu His Glu Lys Thr His Asn Glu Glu Lys 
                405                 410                 415     


Pro Tyr Ile Cys Ser Glu Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr 
            420                 425                 430         


Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Ser Tyr Glu Cys 
        435                 440                 445             


Pro His Cys Gly Lys Ala Phe Arg Met Lys Ser Tyr Leu Ile Asp His 
    450                 455                 460                 


His Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly 
465                 470                 475                 480 


Lys Ser Phe Ser Gln Lys Thr Asn Leu Asn Leu His Gln Arg Ile His 
                485                 490                 495     


Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ser Phe Arg 
            500                 505                 510         


Gln Lys Ala Thr Leu Thr Val His Gln Lys Ile His Thr Gly Gln Lys 
        515                 520                 525             


Ser Tyr Glu Cys Pro Gln Cys Gly Lys Ala Phe Ser Arg Lys Ser Tyr 
    530                 535                 540                 


Leu Ile His His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
545                 550                 555                 560 


Ser Glu Cys Gly Lys Cys Phe Arg Gln Lys Thr Asn Leu Ile Val His 
                565                 570                 575     


Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly 
            580                 585                 590         


Lys Ser Phe Ser Tyr Lys Arg Asn Leu Ile Val His Gln Arg Thr His 
        595                 600                 605             


Lys Gly Glu Asn Ile Glu Met Gln 
    610                 615     


<210> 6023
<211> 146
<212> PRT
<213> Homo sapiens

<400> 6023
Met Cys His Thr Ser Cys Ser Ser Gly Cys Gln Pro Ala Cys Cys Ala 
1               5                   10                  15      


Pro Ser Pro Cys Gln Pro Ala Cys Cys Val Pro Ser Ser Cys Gln Ala 
            20                  25                  30          


Ser Cys Cys Val Pro Val Gly Cys Gln Ser Ser Val Cys Val Pro Val 
        35                  40                  45              


Ser Phe Lys Pro Ala Val Cys Leu Pro Val Ser Cys Gln Ser Ser Val 
    50                  55                  60                  


Cys Val Pro Met Ser Phe Lys Ser Ala Val Cys Val Pro Val Ser Cys 
65                  70                  75                  80  


Gln Ser Ser Val Cys Val Pro Val Ser Cys Arg Pro Ile Val Cys Ala 
                85                  90                  95      


Ala Pro Ser Cys Gln Ser Ser Leu Cys Val Pro Val Ser Cys Arg Pro 
            100                 105                 110         


Val Val Tyr Ala Ala Pro Ser Cys Gln Ser Ser Gly Cys Cys Gln Pro 
        115                 120                 125             


Ser Cys Thr Ser Val Leu Cys Arg Pro Ile Ser Tyr Ser Ile Ser Ser 
    130                 135                 140                 


Cys Cys 
145     


<210> 6024
<211> 418
<212> PRT
<213> Homo sapiens

<400> 6024
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Val Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Leu 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Ala Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ala Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Met Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp Leu Ala Ala Leu Glu Lys Asp Tyr 
385                 390                 395                 400 


Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu Gly Glu 
                405                 410                 415     


Glu Tyr 
        


<210> 6025
<211> 1116
<212> PRT
<213> Homo sapiens

<400> 6025
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Val Glu Gln Leu Lys Glu Glu Leu Ser 
        435                 440                 445             


Ser Lys Glu Ala Gln Trp Glu Glu Leu Lys Lys Lys Ala Ala Gly Leu 
    450                 455                 460                 


Gln Ala Glu Ile Gly Gln Val Lys Gln Glu Leu Ser Arg Lys Asp Thr 
465                 470                 475                 480 


Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu Thr Asn Gln Phe 
                485                 490                 495     


Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu Ser Leu Thr Ala 
            500                 505                 510         


Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val Asp Ala Leu Arg 
        515                 520                 525             


Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys Lys Thr Lys Gln 
    530                 535                 540                 


Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala Gly Glu Ile His 
545                 550                 555                 560 


Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys Val Asn Val Leu 
                565                 570                 575     


Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg Asp Lys Glu Lys 
            580                 585                 590         


Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu Gln Ala Asp Thr 
        595                 600                 605             


Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu Ala Leu Ala Glu 
    610                 615                 620                 


Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg Asp Arg Asp Glu 
625                 630                 635                 640 


Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys Asp Leu Lys Asp 
                645                 650                 655     


Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu Ser Glu Lys Glu 
            660                 665                 670         


Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser Leu Ala Ser Ser 
        675                 680                 685             


Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu Ile Ala Leu Glu 
    690                 695                 700                 


Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln Leu Lys Lys Ala 
705                 710                 715                 720 


His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu Met Ser Asp Arg 
                725                 730                 735     


Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys Asp Glu Ser Ser 
            740                 745                 750         


Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile Leu Lys Glu Val 
        755                 760                 765             


Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala Glu Leu Glu Arg 
    770                 775                 780                 


Gln Val Lys Asp Gln Asn Lys Lys Val Ala Asn Leu Lys His Lys Glu 
785                 790                 795                 800 


Gln Val Glu Lys Lys Lys Ser Ala Gln Met Leu Glu Glu Ala Arg Arg 
                805                 810                 815     


Arg Glu Asp Asn Leu Asn Asp Ser Ser Gln Gln Leu Gln Asp Ser Leu 
            820                 825                 830         


Arg Lys Lys Asp Asp Arg Ile Glu Glu Leu Glu Glu Ala Leu Arg Glu 
        835                 840                 845             


Ser Val Gln Ile Thr Ala Glu Arg Glu Met Val Leu Ala Gln Glu Glu 
    850                 855                 860                 


Ser Ala Arg Thr Asn Ala Glu Lys Gln Val Glu Glu Leu Leu Met Ala 
865                 870                 875                 880 


Met Glu Lys Val Lys Gln Glu Leu Glu Ser Met Lys Ala Lys Leu Ser 
                885                 890                 895     


Ser Thr Gln Gln Ser Leu Ala Glu Lys Glu Thr His Leu Thr Asn Leu 
            900                 905                 910         


Arg Ala Glu Arg Arg Lys His Leu Glu Glu Val Leu Glu Met Lys Gln 
        915                 920                 925             


Glu Ala Leu Leu Ala Ala Ile Ser Glu Lys Asp Ala Asn Ile Ala Leu 
    930                 935                 940                 


Leu Glu Leu Ser Ser Ser Lys Lys Lys Thr Gln Glu Glu Val Ala Ala 
945                 950                 955                 960 


Leu Lys Arg Glu Lys Asp Arg Leu Val Gln Gln Leu Lys Gln Gln Thr 
                965                 970                 975     


Gln Asn Arg Met Lys Leu Met Ala Asp Asn Tyr Glu Asp Asp His Phe 
            980                 985                 990         


Lys Ser Ser His Ser Asn Gln Thr  Asn His Lys Pro Ser  Pro Asp Gln 
        995                 1000                 1005             


Ile Ile  Gln Pro Leu Leu Glu  Leu Asp Gln Asn Arg  Ser Lys Leu 
    1010                 1015                 1020             


Lys Leu  Tyr Ile Gly His Leu  Thr Thr Leu Cys His  Asp Arg Asp 
    1025                 1030                 1035             


Pro Leu  Ile Leu Arg Gly Leu  Thr Pro Pro Ala Ser  Tyr Asn Leu 
    1040                 1045                 1050             


Asp Asp  Asp Gln Ala Ala Trp  Glu Asn Glu Leu Gln  Lys Met Thr 
    1055                 1060                 1065             


Arg Gly  Gln Leu Gln Asp Glu  Leu Glu Lys Gly Glu  Arg Asp Asn 
    1070                 1075                 1080             


Ala Glu  Leu Gln Glu Phe Ala  Asn Ala Ile Leu Gln  Gln Ile Ala 
    1085                 1090                 1095             


Asp His  Cys Pro Asp Ile Leu  Glu Gln Val Val Asn  Ala Leu Glu 
    1100                 1105                 1110             


Glu Ser  Ser 
    1115     


<210> 6026
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 6026
Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser Glu Gly 
                85                  90                  95      


Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His Thr Pro 
            100                 105                 110         


Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe 
        115                 120                 125             


Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys Asp Gln 
    130                 135                 140                 


His His His Arg Val Glu Gln Leu Thr Leu Asn Gly Leu Leu Gln Ala 
145                 150                 155                 160 


Leu Gln Ser Pro Cys Ile Ile Glu Gly Glu Ser Gly Lys Gly Lys Ser 
                165                 170                 175     


Thr Leu Leu Gln Arg Ile Ala Met Leu Trp Gly Ser Gly Lys Cys Lys 
            180                 185                 190         


Ala Leu Thr Lys Phe Lys Phe Val Phe Phe Leu Arg Leu Ser Arg Ala 
        195                 200                 205             


Gln Gly Gly Leu Phe Glu Thr Leu Cys Asp Gln Leu Leu Asp Ile Pro 
    210                 215                 220                 


Gly Thr Ile Arg Lys Gln Thr Phe Met Ala Met Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Gln Arg Val Leu Phe Leu Leu Asp Gly Tyr Asn Glu Phe Lys Pro Gln 
                245                 250                 255     


Asn Cys Pro Glu Ile Glu Ala Leu Ile Lys Glu Asn His Arg Phe Lys 
            260                 265                 270         


Asn Met Val Ile Val Thr Thr Thr Thr Glu Cys Leu Arg His Ile Arg 
        275                 280                 285             


Gln Phe Gly Ala Leu Thr Ala Glu Val Gly Asp Met Thr Glu Asp Ser 
    290                 295                 300                 


Ala Gln Ala Leu Ile Arg Glu Val Leu Ile Lys Glu Leu Ala Glu Gly 
305                 310                 315                 320 


Leu Leu Leu Gln Ile Gln Lys Ser Arg Cys Leu Arg Asn Leu Met Lys 
                325                 330                 335     


Thr Pro Leu Phe Val Val Ile Thr Cys Ala Ile Gln Met Gly Glu Ser 
            340                 345                 350         


Glu Phe His Ser His Thr Gln Thr Thr Leu Phe His Thr Phe Tyr Asp 
        355                 360                 365             


Leu Leu Ile Gln Lys Asn Lys His Lys His Lys Gly Val Ala Ala Ser 
    370                 375                 380                 


Asp Phe Ile Arg Ser Leu Asp His Cys Gly Asp Leu Ala Leu Glu Gly 
385                 390                 395                 400 


Val Phe Ser His Lys Phe Asp Phe Glu Leu Gln Asp Val Ser Ser Val 
                405                 410                 415     


Asn Glu Asp Val Leu Leu Thr Thr Gly Leu Leu Cys Lys Tyr Thr Ala 
            420                 425                 430         


Gln Arg Phe Lys Pro Lys Tyr Lys Phe Phe His Lys Ser Phe Gln Glu 
        435                 440                 445             


Tyr Thr Ala Gly Arg Arg Leu Ser Ser Leu Leu Thr Ser His Glu Pro 
    450                 455                 460                 


Glu Glu Val Thr Lys Gly Asn Gly Tyr Leu Gln Lys Met Val Ser Ile 
465                 470                 475                 480 


Ser Asp Ile Thr Ser Thr Tyr Ser Ser Leu Leu Arg Tyr Thr Cys Gly 
                485                 490                 495     


Ser Ser Val Glu Ala Thr Arg Ala Val Met Lys His Leu Ala Ala Val 
            500                 505                 510         


Tyr Gln His Gly Cys Leu Leu Gly Leu Ser Ile Ala Lys Arg Pro Leu 
        515                 520                 525             


Trp Arg Gln Glu Ser Leu Gln Ser Val Lys Asn Thr Thr Glu Gln Glu 
    530                 535                 540                 


Ile Leu Lys Ala Ile Asn Ile Asn Ser Phe Val Glu Cys Gly Ile His 
545                 550                 555                 560 


Leu Tyr Gln Glu Ser Thr Ser Lys Ser Ala Leu Ser Gln Glu Phe Glu 
                565                 570                 575     


Ala Phe Phe Gln Gly Lys Ser Leu Tyr Ile Asn Ser Gly Asn Ile Pro 
            580                 585                 590         


Asp Tyr Leu Phe Asp Phe Phe Glu His Leu Pro Asn Cys Ala Ser Ala 
        595                 600                 605             


Leu Asp Phe Ile Lys Leu Asp Phe Tyr Gly Gly Ala Met Ala Ser Trp 
    610                 615                 620                 


Glu Lys Ala Ala Glu Asp Thr Gly Gly Ile His Met Glu Glu Ala Pro 
625                 630                 635                 640 


Glu Thr Tyr Ile Pro Ser Arg Ala Val Ser Leu Phe Phe Asn Trp Lys 
                645                 650                 655     


Gln Glu Phe Arg Thr Leu Glu Val Thr Leu Arg Asp Phe Ser Lys Leu 
            660                 665                 670         


Asn Lys Gln Asp Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr 
        675                 680                 685             


Ser Leu Arg Leu Gln Ile Lys Arg Cys Ala Gly Val Ala Gly Ser Leu 
    690                 695                 700                 


Ser Leu Val Leu Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met Val Glu 
705                 710                 715                 720 


Ala Ser Pro Leu Thr Ile Glu Asp Glu Arg His Ile Thr Ser Val Thr 
                725                 730                 735     


Asn Leu Lys Thr Leu Ser Ile His Asp Leu Gln Asn Gln Arg Leu Pro 
            740                 745                 750         


Gly Gly Leu Thr Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu 
        755                 760                 765             


Ile Met Asp Asn Ile Lys Met Asn Glu Glu Asp Ala Ile Lys Leu Ala 
    770                 775                 780                 


Glu Gly Leu Lys Asn Leu Lys Lys Met Cys Leu Phe His Leu Thr His 
785                 790                 795                 800 


Leu Ser Asp Ile Gly Glu Gly Met Asp Tyr Ile Val Lys Ser Leu Ser 
                805                 810                 815     


Ser Glu Pro Cys Asp Leu Glu Glu Ile Gln Leu Val Ser Cys Cys Leu 
            820                 825                 830         


Ser Ala Asn Ala Val Lys Ile Leu Ala Gln Asn Leu His Asn Leu Val 
        835                 840                 845             


Lys Leu Ser Ile Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly 
    850                 855                 860                 


Asn Glu Ala Leu His Glu Leu Ile Asp Arg Met Asn Val Leu Glu Gln 
865                 870                 875                 880 


Leu Thr Ala Leu Met Leu Pro Trp Gly Cys Asp Val Gln Gly Ser Leu 
                885                 890                 895     


Ser Ser Leu Leu Lys His Leu Glu Glu Val Pro Gln Leu Val Lys Leu 
            900                 905                 910         


Gly Leu Lys Asn Trp Arg Leu Thr Asp Thr Glu Ile Arg Ile Leu Gly 
        915                 920                 925             


Ala Phe Phe Gly Lys Asn Pro Leu Lys Asn Phe Gln Gln Leu Asn Leu 
    930                 935                 940                 


Ala Gly Asn Arg Val Ser Ser Asp Gly Trp Leu Ala Phe Met Gly Val 
945                 950                 955                 960 


Phe Glu Asn Leu Lys Gln Leu Val Phe Phe Asp Phe Ser Thr Lys Glu 
                965                 970                 975     


Phe Leu Pro Asp Pro Ala Leu Val Arg Lys Leu Ser Gln Val Leu Ser 
            980                 985                 990         


Lys Leu Thr Phe Leu Gln Glu Ala  Arg Leu Val Gly Trp  Gln Phe Asp 
        995                 1000                 1005             


Asp Asp  Asp Leu Ser Val Ile  Thr Gly Ala Phe Lys  Leu Val Thr 
    1010                 1015                 1020             


Ala 
    


<210> 6027
<211> 354
<212> PRT
<213> Homo sapiens

<400> 6027
Met Ala Glu Ser Pro Thr Glu Glu Ala Ala Thr Ala Gly Ala Gly Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ala Ser Ser Val Ala Gly Val Val Gly Val Ser Gly 
            20                  25                  30          


Ser Gly Gly Gly Phe Gly Pro Pro Phe Leu Pro Asp Val Trp Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Gly Gly Ala Gly Gly Pro Gly Ser Gly Leu Ala Pro 
    50                  55                  60                  


Leu Pro Gly Leu Pro Pro Ser Ala Ala Ala His Gly Ala Ala Leu Leu 
65                  70                  75                  80  


Ser His Trp Asp Pro Thr Leu Ser Ser Asp Trp Asp Gly Glu Arg Thr 
                85                  90                  95      


Ala Pro Gln Cys Leu Leu Arg Ile Lys Arg Asp Ile Met Ser Ile Tyr 
            100                 105                 110         


Lys Glu Pro Pro Pro Gly Met Phe Val Val Pro Asp Thr Val Asp Met 
        115                 120                 125             


Thr Lys Ile His Ala Leu Ile Thr Gly Pro Phe Asp Thr Pro Tyr Glu 
    130                 135                 140                 


Gly Gly Phe Phe Leu Phe Val Phe Arg Cys Pro Pro Asp Tyr Pro Ile 
145                 150                 155                 160 


His Pro Pro Arg Val Lys Leu Met Thr Thr Gly Asn Asn Thr Val Arg 
                165                 170                 175     


Phe Asn Pro Asn Phe Tyr Arg Asn Gly Lys Val Cys Leu Ser Ile Leu 
            180                 185                 190         


Gly Thr Trp Thr Gly Pro Ala Trp Ser Pro Ala Gln Ser Ile Ser Ser 
        195                 200                 205             


Val Leu Ile Ser Ile Gln Ser Leu Met Thr Glu Asn Pro Tyr His Asn 
    210                 215                 220                 


Glu Pro Gly Phe Glu Gln Glu Arg His Pro Gly Asp Ser Lys Asn Tyr 
225                 230                 235                 240 


Asn Glu Cys Ile Arg His Glu Thr Ile Arg Val Ala Val Cys Asp Met 
                245                 250                 255     


Met Glu Gly Lys Cys Pro Cys Pro Glu Pro Leu Arg Gly Val Met Glu 
            260                 265                 270         


Lys Ser Phe Leu Glu Tyr Tyr Asp Phe Tyr Glu Val Ala Cys Lys Asp 
        275                 280                 285             


Arg Leu His Leu Gln Gly Gln Thr Met Gln Asp Pro Phe Gly Glu Lys 
    290                 295                 300                 


Arg Gly His Phe Asp Tyr Gln Ser Leu Leu Met Arg Leu Gly Leu Ile 
305                 310                 315                 320 


Arg Gln Lys Val Leu Glu Arg Leu His Asn Glu Asn Ala Glu Met Asp 
                325                 330                 335     


Ser Asp Ser Ser Ser Ser Gly Thr Glu Thr Asp Leu His Gly Ser Leu 
            340                 345                 350         


Arg Val 
        


<210> 6028
<211> 828
<212> PRT
<213> Homo sapiens

<400> 6028
Met Asp Ser Glu Ala Phe Gln Ser Ala Arg Asp Phe Leu Asp Met Asn 
1               5                   10                  15      


Phe Gln Ser Leu Ala Met Lys His Met Asp Leu Lys Gln Met Glu Leu 
            20                  25                  30          


Asp Thr Ala Ala Ala Lys Val Asp Glu Leu Thr Lys Gln Leu Glu Ser 
        35                  40                  45              


Leu Trp Ser Asp Ser Pro Ala Pro Pro Gly Pro Gln Ala Gly Pro Pro 
    50                  55                  60                  


Ser Arg Pro Pro Arg Tyr Ser Ser Ser Ser Ile Pro Glu Pro Phe Gly 
65                  70                  75                  80  


Ser Arg Gly Ser Pro Arg Lys Ala Ala Thr Asp Gly Ala Asp Thr Pro 
                85                  90                  95      


Phe Gly Arg Ser Glu Ser Ala Pro Thr Leu His Pro Tyr Ser Pro Leu 
            100                 105                 110         


Ser Pro Lys Gly Arg Pro Ser Ser Pro Arg Thr Pro Leu Tyr Leu Gln 
        115                 120                 125             


Pro Asp Ala Tyr Gly Ser Leu Asp Arg Ala Thr Ser Pro Arg Pro Arg 
    130                 135                 140                 


Ala Phe Asp Gly Ala Gly Ser Ser Leu Gly Arg Ala Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Gly Pro Gly Pro Leu Arg Gln Gln Gly Pro Pro Thr Pro Phe Asp 
                165                 170                 175     


Phe Leu Gly Arg Ala Gly Ser Pro Arg Gly Ser Pro Leu Ala Glu Gly 
            180                 185                 190         


Pro Gln Ala Phe Phe Pro Glu Arg Gly Pro Ser Pro Arg Pro Pro Ala 
        195                 200                 205             


Thr Ala Tyr Asp Ala Pro Ala Ser Ala Phe Gly Ser Ser Leu Leu Gly 
    210                 215                 220                 


Ser Gly Gly Ser Ala Phe Ala Pro Pro Leu Arg Ala Gln Asp Asp Leu 
225                 230                 235                 240 


Thr Leu Arg Arg Arg Pro Pro Lys Ala Trp Asn Glu Ser Asp Leu Asp 
                245                 250                 255     


Val Ala Tyr Glu Lys Lys Pro Ser Gln Thr Ala Ser Tyr Glu Arg Leu 
            260                 265                 270         


Asp Val Phe Ala Arg Pro Ala Ser Pro Ser Leu Gln Leu Leu Pro Trp 
        275                 280                 285             


Arg Glu Ser Ser Leu Asp Gly Leu Gly Gly Thr Gly Lys Asp Asn Leu 
    290                 295                 300                 


Thr Ser Ala Thr Leu Pro Arg Asn Tyr Lys Val Ser Pro Leu Ala Ser 
305                 310                 315                 320 


Asp Arg Arg Ser Asp Ala Gly Ser Tyr Arg Arg Ser Leu Gly Ser Ala 
                325                 330                 335     


Gly Pro Ser Gly Thr Leu Pro Arg Ser Trp Gln Pro Val Ser Arg Ile 
            340                 345                 350         


Pro Met Pro Pro Ser Ser Pro Gln Pro Arg Gly Ala Pro Arg Gln Arg 
        355                 360                 365             


Pro Ile Pro Leu Ser Met Ile Phe Lys Leu Gln Asn Ala Phe Trp Glu 
    370                 375                 380                 


His Gly Ala Ser Arg Ala Met Leu Pro Gly Ser Pro Leu Phe Thr Arg 
385                 390                 395                 400 


Ala Pro Pro Pro Lys Leu Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro 
                405                 410                 415     


Gln Ser Gln Pro Gln Pro Gln Leu Pro Pro Gln Pro Gln Thr Gln Pro 
            420                 425                 430         


Gln Thr Pro Thr Pro Ala Pro Gln His Pro Gln Gln Thr Trp Pro Pro 
        435                 440                 445             


Val Asn Glu Gly Pro Pro Lys Pro Pro Thr Glu Leu Glu Pro Glu Pro 
    450                 455                 460                 


Glu Ile Glu Gly Leu Leu Thr Pro Val Leu Glu Ala Gly Asp Val Asp 
465                 470                 475                 480 


Glu Gly Pro Val Ala Arg Pro Leu Ser Pro Thr Arg Leu Gln Pro Ala 
                485                 490                 495     


Leu Pro Pro Glu Ala Gln Ser Val Pro Glu Leu Glu Glu Val Ala Arg 
            500                 505                 510         


Val Leu Ala Glu Ile Pro Arg Pro Leu Lys Arg Arg Gly Ser Met Glu 
        515                 520                 525             


Gln Ala Pro Ala Val Ala Leu Pro Pro Thr His Lys Lys Gln Tyr Gln 
    530                 535                 540                 


Gln Ile Ile Ser Arg Leu Phe His Arg His Gly Gly Pro Gly Pro Gly 
545                 550                 555                 560 


Gly Pro Glu Pro Glu Leu Ser Pro Ile Thr Glu Gly Ser Glu Ala Arg 
                565                 570                 575     


Ala Gly Pro Pro Ala Pro Ala Pro Pro Ala Pro Ile Pro Pro Pro Ala 
            580                 585                 590         


Pro Ser Gln Ser Ser Pro Pro Glu Gln Pro Gln Ser Met Glu Met Arg 
        595                 600                 605             


Ser Val Leu Arg Lys Ala Gly Ser Pro Arg Lys Ala Arg Arg Ala Arg 
    610                 615                 620                 


Leu Asn Pro Leu Val Leu Leu Leu Asp Ala Ala Leu Thr Gly Glu Leu 
625                 630                 635                 640 


Glu Val Val Gln Gln Ala Val Lys Glu Met Asn Asp Pro Ser Gln Pro 
                645                 650                 655     


Asn Glu Glu Gly Ile Thr Ala Leu His Asn Ala Ile Cys Gly Ala Asn 
            660                 665                 670         


Tyr Ser Ile Val Asp Phe Leu Ile Thr Ala Gly Ala Asn Val Asn Ser 
        675                 680                 685             


Pro Asp Ser His Gly Trp Thr Pro Leu His Cys Ala Ala Ser Cys Asn 
    690                 695                 700                 


Asp Thr Val Ile Cys Met Ala Leu Val Gln His Gly Ala Ala Ile Phe 
705                 710                 715                 720 


Ala Thr Thr Leu Ser Asp Gly Ala Thr Ala Phe Glu Lys Cys Asp Pro 
                725                 730                 735     


Tyr Arg Glu Gly Tyr Ala Asp Cys Ala Thr Tyr Leu Ala Asp Val Glu 
            740                 745                 750         


Gln Ser Met Gly Leu Met Asn Ser Gly Ala Val Tyr Ala Leu Trp Asp 
        755                 760                 765             


Tyr Ser Ala Glu Phe Gly Asp Glu Leu Ser Phe Arg Glu Gly Glu Ser 
    770                 775                 780                 


Val Thr Val Leu Arg Arg Asp Gly Pro Glu Glu Thr Asp Trp Trp Trp 
785                 790                 795                 800 


Ala Ala Leu His Gly Gln Glu Gly Tyr Val Pro Arg Asn Tyr Phe Gly 
                805                 810                 815     


Leu Phe Pro Arg Val Lys Pro Gln Arg Ser Lys Val 
            820                 825             


<210> 6029
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6029
Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Cys Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Ser Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Ser Leu Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Gly 
    370                 375     


<210> 6030
<211> 254
<212> PRT
<213> Homo sapiens

<400> 6030
Met Pro Ala Ser Phe Pro Met Leu Arg Cys Ala Arg Ser Pro Cys Trp 
1               5                   10                  15      


Thr Val Cys Trp Ser Pro Trp Cys Arg Ala Leu Pro Asp Gly Arg Cys 
            20                  25                  30          


Ser Cys Leu Ser Ser Pro Pro Ser Pro Leu Gly Pro Thr Arg Asp Pro 
        35                  40                  45              


Val Ala Thr Phe Leu Glu Thr Cys Arg Glu Pro Gly Ser Gln Pro Ala 
    50                  55                  60                  


Gly Pro Ala Ser Leu Arg Ala Glu Tyr Leu Pro Pro Ser Val Ala Ser 
65                  70                  75                  80  


Ile Lys Val Ser Ala Glu Leu Leu Arg Ala Ala Leu Lys Asp Gly His 
                85                  90                  95      


Ser Gly Val Pro Leu Cys Cys Ala Thr Leu Gln Trp Leu Leu Ala Glu 
            100                 105                 110         


Asn Ala Ala Val Asp Val Val Arg Ala Arg Ala Leu Ser Ser Ile Gln 
        115                 120                 125             


Gly Val Ala Pro Asp Gly Ala Asn Val His Leu Ile Val Arg Glu Val 
    130                 135                 140                 


Ala Met Thr Asp Leu Cys Pro Ala Gly Pro Ile Gln Ala Val Glu Ile 
145                 150                 155                 160 


Gln Val Glu Ser Ser Ser Leu Ala Asp Ile Cys Arg Ala His His Ala 
                165                 170                 175     


Val Val Gly Arg Met Gln Thr Met Val Thr Glu Gln Ala Thr Gln Gly 
            180                 185                 190         


Ser Ser Ala Pro Asp Leu Arg Val Gln Tyr Leu Arg Gln Ile His Ala 
        195                 200                 205             


Asn His Glu Thr Leu Leu Arg Glu Val Gln Thr Leu Arg Asp Arg Leu 
    210                 215                 220                 


Cys Thr Glu Asp Glu Ala Ser Ser Cys Ala Thr Ala Gln Arg Leu Leu 
225                 230                 235                 240 


Gln Val Tyr Arg Gln Leu Arg His Pro Ser Leu Ile Leu Leu 
                245                 250                 


<210> 6031
<211> 681
<212> PRT
<213> Homo sapiens

<400> 6031
Met Cys Gly Ile Phe Ala Tyr Leu Asn Tyr His Val Pro Arg Thr Arg 
1               5                   10                  15      


Arg Glu Ile Leu Glu Thr Leu Ile Lys Gly Leu Gln Arg Leu Glu Tyr 
            20                  25                  30          


Arg Gly Tyr Asp Ser Ala Gly Val Gly Phe Asp Gly Gly Asn Asp Lys 
        35                  40                  45              


Asp Trp Glu Ala Asn Ala Cys Lys Ile Gln Leu Ile Lys Lys Lys Gly 
    50                  55                  60                  


Lys Val Lys Ala Leu Asp Glu Glu Val His Lys Gln Gln Asp Met Asp 
65                  70                  75                  80  


Leu Asp Ile Glu Phe Asp Val His Leu Gly Ile Ala His Thr Arg Trp 
                85                  90                  95      


Ala Thr His Gly Glu Pro Ser Pro Val Asn Ser His Pro Gln Arg Ser 
            100                 105                 110         


Asp Lys Asn Asn Glu Phe Ile Val Ile His Asn Gly Ile Ile Thr Asn 
        115                 120                 125             


Tyr Lys Asp Leu Lys Lys Phe Leu Glu Ser Lys Gly Tyr Asp Phe Glu 
    130                 135                 140                 


Ser Glu Thr Asp Thr Glu Thr Ile Ala Lys Leu Val Lys Tyr Met Tyr 
145                 150                 155                 160 


Asp Asn Arg Glu Ser Gln Asp Thr Ser Phe Thr Thr Leu Val Glu Arg 
                165                 170                 175     


Val Ile Gln Gln Leu Glu Gly Ala Phe Ala Leu Val Phe Lys Ser Val 
            180                 185                 190         


His Phe Pro Gly Gln Ala Val Gly Thr Arg Arg Gly Ser Pro Leu Leu 
        195                 200                 205             


Ile Gly Val Arg Ser Glu His Lys Leu Ser Thr Asp His Ile Pro Ile 
    210                 215                 220                 


Leu Tyr Arg Thr Gly Lys Asp Lys Lys Gly Ser Cys Asn Leu Ser Arg 
225                 230                 235                 240 


Val Asp Ser Thr Thr Cys Leu Phe Pro Val Glu Glu Lys Ala Val Glu 
                245                 250                 255     


Tyr Tyr Phe Ala Ser Asp Ala Ser Ala Val Ile Glu His Thr Asn Arg 
            260                 265                 270         


Val Ile Phe Leu Glu Asp Asp Asp Val Ala Ala Val Val Asp Gly Arg 
        275                 280                 285             


Leu Ser Ile His Arg Ile Lys Arg Thr Ala Gly Asp His Pro Gly Arg 
    290                 295                 300                 


Ala Val Gln Thr Leu Gln Met Glu Leu Gln Gln Ile Met Lys Gly Asn 
305                 310                 315                 320 


Phe Ser Ser Phe Met Gln Lys Glu Ile Phe Glu Gln Pro Glu Ser Val 
                325                 330                 335     


Val Asn Thr Met Arg Gly Arg Val Asn Phe Asp Asp Tyr Thr Val Asn 
            340                 345                 350         


Leu Gly Gly Leu Lys Asp His Ile Lys Glu Ile Gln Arg Cys Arg Arg 
        355                 360                 365             


Leu Ile Leu Ile Ala Cys Gly Thr Ser Tyr His Ala Gly Val Ala Thr 
    370                 375                 380                 


Arg Gln Val Leu Glu Glu Leu Thr Glu Leu Pro Val Met Val Glu Leu 
385                 390                 395                 400 


Ala Ser Asp Phe Leu Asp Arg Asn Thr Pro Val Phe Arg Asp Asp Val 
                405                 410                 415     


Cys Phe Phe Leu Ser Gln Ser Gly Glu Thr Ala Asp Thr Leu Met Gly 
            420                 425                 430         


Leu Arg Tyr Cys Lys Glu Arg Gly Ala Leu Thr Val Gly Ile Thr Asn 
        435                 440                 445             


Thr Val Gly Ser Ser Ile Ser Arg Glu Thr Asp Cys Gly Val His Ile 
    450                 455                 460                 


Asn Ala Gly Pro Glu Ile Gly Val Ala Ser Thr Lys Ala Tyr Thr Ser 
465                 470                 475                 480 


Gln Phe Val Ser Leu Val Met Phe Ala Leu Met Met Cys Asp Asp Arg 
                485                 490                 495     


Ile Ser Met Gln Glu Arg Arg Lys Glu Ile Met Leu Gly Leu Lys Arg 
            500                 505                 510         


Leu Pro Asp Leu Ile Lys Glu Val Leu Ser Met Asp Asp Glu Ile Gln 
        515                 520                 525             


Lys Leu Ala Thr Glu Leu Tyr His Gln Lys Ser Val Leu Ile Met Gly 
    530                 535                 540                 


Arg Gly Tyr His Tyr Ala Thr Cys Leu Glu Gly Ala Leu Lys Ile Lys 
545                 550                 555                 560 


Glu Ile Thr Tyr Met His Ser Glu Gly Ile Leu Ala Gly Glu Leu Lys 
                565                 570                 575     


His Gly Pro Leu Ala Leu Val Asp Lys Leu Met Pro Val Ile Met Ile 
            580                 585                 590         


Ile Met Arg Asp His Thr Tyr Ala Lys Cys Gln Asn Ala Leu Gln Gln 
        595                 600                 605             


Val Val Ala Arg Gln Gly Arg Pro Val Val Ile Cys Asp Lys Glu Asp 
    610                 615                 620                 


Thr Glu Thr Ile Lys Asn Thr Lys Arg Thr Ile Lys Val Pro His Ser 
625                 630                 635                 640 


Val Asp Cys Leu Gln Gly Ile Leu Ser Val Ile Pro Leu Gln Leu Leu 
                645                 650                 655     


Ala Phe His Leu Ala Val Leu Arg Gly Tyr Asp Val Asp Phe Pro Arg 
            660                 665                 670         


Asn Leu Ala Lys Ser Val Thr Val Glu 
        675                 680     


<210> 6032
<211> 165
<212> PRT
<213> Homo sapiens

<400> 6032
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Ser Trp Glu Pro Leu Leu Lys 
    130                 135                 140                 


Ala Pro Ser Pro Phe Thr Ile Ser Thr Thr Pro Ser Phe Arg Pro Cys 
145                 150                 155                 160 


Ser Asn Pro Val Thr 
                165 


<210> 6033
<211> 210
<212> PRT
<213> Homo sapiens

<400> 6033
Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu 
            100                 105                 110         


Ser Gly Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu 
        115                 120                 125             


Pro Gly Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala 
    130                 135                 140                 


Ala Asn Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp 
145                 150                 155                 160 


Gln Asp Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro 
                165                 170                 175     


Asn His Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu 
            180                 185                 190         


Asp Lys Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly 
        195                 200                 205             


Leu Gln 
    210 


<210> 6034
<211> 415
<212> PRT
<213> Homo sapiens

<400> 6034
Met Arg Ala Ala Asp Ser Gly Ser Trp Glu Arg Val Arg Gln Leu Ala 
1               5                   10                  15      


Ala Gln Gly Glu Pro Ala Pro Ser Cys Gly Ala Gly Ala Gly Pro Ala 
            20                  25                  30          


Arg Pro Pro Gly Pro Ala Ala Cys Glu Gln Cys Val Asp Ala Ala Gly 
        35                  40                  45              


Pro Gly Asp Arg Pro Arg Ala Gly Val Pro Arg Val Arg Ala Asp Gly 
    50                  55                  60                  


Asp Cys Ser Gln Pro Val Leu Leu Arg Glu Glu Val Ser Arg Leu Gln 
65                  70                  75                  80  


Glu Glu Val His Leu Leu Arg Gln Met Lys Glu Met Leu Ala Lys Asp 
                85                  90                  95      


Leu Glu Glu Ser Gln Gly Gly Lys Ser Ser Glu Val Leu Ser Ala Thr 
            100                 105                 110         


Glu Leu Arg Val Gln Leu Ala Gln Lys Glu Gln Glu Leu Ala Arg Ala 
        115                 120                 125             


Lys Glu Ala Leu Gln Ala Met Lys Ala Asp Arg Lys Arg Leu Lys Gly 
    130                 135                 140                 


Glu Lys Thr Asp Leu Val Ser Gln Met Gln Gln Leu Tyr Ala Thr Leu 
145                 150                 155                 160 


Glu Ser Arg Glu Glu Gln Leu Arg Asp Phe Ile Arg Asn Tyr Glu Gln 
                165                 170                 175     


His Arg Lys Glu Ser Glu Asp Ala Val Lys Ala Leu Ala Lys Glu Lys 
            180                 185                 190         


Asp Leu Leu Glu Arg Glu Lys Trp Glu Leu Arg Arg Gln Ala Lys Glu 
        195                 200                 205             


Ala Thr Asp His Ala Thr Ala Leu Arg Ser Gln Leu Asp Leu Lys Asp 
    210                 215                 220                 


Asn Arg Met Lys Glu Leu Glu Ala Glu Leu Ala Met Ala Lys Gln Ser 
225                 230                 235                 240 


Leu Ala Thr Leu Thr Lys Asp Val Pro Lys Arg His Ser Leu Ala Met 
                245                 250                 255     


Pro Gly Glu Thr Val Leu Asn Gly Asn Gln Glu Trp Val Val Gln Ala 
            260                 265                 270         


Asp Leu Pro Leu Thr Ala Ala Ile Arg Gln Ser Gln Gln Thr Leu Tyr 
        275                 280                 285             


His Ser His Pro Pro His Pro Ala Asp Arg Gln Ala Val Arg Val Ser 
    290                 295                 300                 


Pro Cys His Ser Arg Gln Pro Ser Val Ile Ser Asp Ala Ser Ala Ala 
305                 310                 315                 320 


Glu Gly Asp Arg Ser Ser Thr Pro Ser Asp Ile Asn Ser Pro Arg His 
                325                 330                 335     


Arg Thr His Ser Leu Cys Asn Gly Asp Ser Pro Gly Pro Val Gln Lys 
            340                 345                 350         


Asn Leu His Asn Pro Ile Val Gln Ser Leu Glu Asp Leu Glu Asp Gln 
        355                 360                 365             


Lys Arg Lys Lys Lys Lys Glu Lys Met Gly Phe Gly Ser Ile Ser Arg 
    370                 375                 380                 


Val Phe Ala Arg Gly Lys Gln Arg Lys Ser Leu Asp Pro Gly Leu Phe 
385                 390                 395                 400 


Asp Gly Thr Ala Pro Asp Tyr Tyr Ile Glu Glu Asp Ala Asp Trp 
                405                 410                 415 


<210> 6035
<211> 230
<212> PRT
<213> Homo sapiens

<400> 6035
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala 
65                  70                  75                  80  


Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp 
                85                  90                  95      


Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile 
            100                 105                 110         


Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg 
        115                 120                 125             


Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met 
    130                 135                 140                 


Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln 
145                 150                 155                 160 


Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Gly Lys Leu 
                165                 170                 175     


Leu Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys 
            180                 185                 190         


Pro Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met 
        195                 200                 205             


Gly Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala 
    210                 215                 220                 


Gly Asp Val Asn Leu Pro 
225                 230 


<210> 6036
<211> 848
<212> PRT
<213> Homo sapiens

<400> 6036
Met Gln Ala Glu Ala Ala Asp Trp Phe Ser Ser Met Pro Phe Gln Lys 
1               5                   10                  15      


His Val Tyr Tyr Pro Leu Ala Ser Gly Pro Glu Gly Pro Asp Val Ala 
            20                  25                  30          


Val Ala Ala Ala Ala Ala Gly Ala Ala Ser Met Ala Cys Ala Pro Pro 
        35                  40                  45              


Ser Ala Ala Ser Gly Pro Leu Pro Phe Phe Gln Phe Arg Pro Arg Leu 
    50                  55                  60                  


Glu Ser Val Asp Trp Arg Arg Leu Ser Ala Ile Asp Val Asp Lys Val 
65                  70                  75                  80  


Ala Gly Ala Val Asp Val Leu Thr Leu Gln Glu Asn Ile Met Asn Ile 
                85                  90                  95      


Thr Phe Cys Lys Leu Glu Asp Glu Lys Cys Pro His Cys Gln Ser Gly 
            100                 105                 110         


Val Asp Pro Val Leu Leu Lys Leu Ile Arg Leu Ala Gln Phe Thr Ile 
        115                 120                 125             


Glu Tyr Leu Leu His Ser Gln Glu Phe Leu Thr Ser Gln Leu His Thr 
    130                 135                 140                 


Leu Glu Glu Arg Leu Arg Leu Ser His Cys Asp Gly Glu Gln Ser Lys 
145                 150                 155                 160 


Lys Leu Leu Thr Lys Gln Ala Gly Glu Ile Lys Thr Leu Lys Glu Glu 
                165                 170                 175     


Cys Lys Arg Arg Lys Lys Met Ile Ser Thr Gln Gln Leu Met Ile Glu 
            180                 185                 190         


Ala Lys Ala Asn Tyr Tyr Gln Cys His Phe Cys Asp Lys Ala Phe Met 
        195                 200                 205             


Asn Gln Ala Phe Leu Gln Ser His Ile Gln Arg Arg His Thr Glu Glu 
    210                 215                 220                 


Asn Ser His Phe Glu Tyr Gln Lys Asn Ala Gln Ile Glu Lys Leu Arg 
225                 230                 235                 240 


Ser Glu Ile Val Val Leu Lys Glu Glu Leu Gln Leu Thr Arg Ser Glu 
                245                 250                 255     


Leu Glu Ala Ala His His Ala Ser Ala Val Arg Phe Ser Lys Glu Tyr 
            260                 265                 270         


Glu Met Gln Lys Thr Lys Glu Glu Asp Phe Leu Lys Leu Phe Asp Arg 
        275                 280                 285             


Trp Lys Glu Glu Glu Lys Glu Lys Leu Val Asp Glu Met Glu Lys Val 
    290                 295                 300                 


Lys Glu Met Phe Met Lys Glu Phe Lys Glu Leu Thr Ser Lys Asn Ser 
305                 310                 315                 320 


Ala Leu Glu Tyr Gln Leu Ser Glu Ile Gln Lys Ser Asn Met Gln Ile 
                325                 330                 335     


Lys Ser Asn Ile Gly Thr Leu Lys Asp Ala His Glu Phe Lys Glu Asp 
            340                 345                 350         


Arg Ser Pro Tyr Pro Gln Asp Phe His Asn Val Met Gln Leu Leu Asp 
        355                 360                 365             


Ser Gln Glu Ser Lys Trp Thr Ala Arg Val Gln Ala Ile His Gln Glu 
    370                 375                 380                 


His Lys Lys Glu Lys Gly Arg Leu Leu Ser His Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Thr Ser Met Ile Asp Asp Leu Asn Ala Ser Asn Val Phe Tyr Lys Lys 
                405                 410                 415     


Arg Ile Glu Glu Leu Gly Gln Arg Leu Gln Glu Gln Asn Glu Leu Ile 
            420                 425                 430         


Ile Thr Gln Arg Gln Gln Ile Lys Asp Phe Thr Cys Asn Pro Leu Asn 
        435                 440                 445             


Ser Ile Ser Glu Pro Lys Val Asn Ala Pro Ala Leu His Thr Leu Glu 
    450                 455                 460                 


Thr Lys Ser Ser Leu Pro Met Val His Glu Gln Ala Phe Ser Ser His 
465                 470                 475                 480 


Ile Leu Glu Pro Ile Glu Glu Leu Ser Glu Glu Glu Lys Gly Arg Glu 
                485                 490                 495     


Asn Glu Gln Lys Leu Asn Asn Asn Lys Met His Leu Arg Lys Ala Leu 
            500                 505                 510         


Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met Val Glu Gln 
        515                 520                 525             


Asn Leu Met Glu Lys Leu Glu Thr Leu Gly Ile Asn Ala Asp Ile Arg 
    530                 535                 540                 


Gly Ile Ser Ser Asp Gln Leu His Arg Val Leu Lys Ser Val Glu Ser 
545                 550                 555                 560 


Glu Arg His Lys Gln Glu Arg Glu Ile Pro Asn Phe His Gln Ile Arg 
                565                 570                 575     


Glu Phe Leu Glu His Gln Val Ser Cys Lys Ile Glu Glu Lys Ala Leu 
            580                 585                 590         


Leu Ser Ser Asp Gln Cys Ser Val Ser Gln Met Asp Thr Leu Ser Thr 
        595                 600                 605             


Gly Glu Val Pro Lys Met Ile Gln Leu Pro Ser Lys Asn Arg Gln Leu 
    610                 615                 620                 


Ile Arg Gln Lys Ala Val Ser Thr Asp Arg Thr Ser Val Pro Lys Ile 
625                 630                 635                 640 


Lys Lys Asn Val Met Glu Asp Pro Phe Pro Arg Lys Ser Ser Thr Ile 
                645                 650                 655     


Thr Thr Pro Pro Phe Ser Ser Glu Glu Glu Gln Glu Asp Asp Asp Leu 
            660                 665                 670         


Ile Arg Ala Tyr Ala Ser Pro Gly Pro Leu Pro Val Pro Pro Pro Gln 
        675                 680                 685             


Asn Lys Gly Ser Phe Gly Lys Asn Thr Val Lys Ser Asp Ala Asp Gly 
    690                 695                 700                 


Thr Glu Gly Ser Glu Ile Glu Asp Thr Asp Asp Ser Pro Lys Pro Ala 
705                 710                 715                 720 


Gly Val Ala Val Lys Thr Pro Thr Glu Lys Val Glu Lys Met Phe Pro 
                725                 730                 735     


His Arg Lys Asn Val Asn Lys Pro Val Gly Gly Thr Asn Val Pro Glu 
            740                 745                 750         


Met Phe Ile Lys Lys Glu Glu Leu Gln Glu Leu Lys Cys Ala Asp Val 
        755                 760                 765             


Glu Asp Glu Asp Trp Asp Ile Ser Ser Leu Glu Glu Glu Ile Ser Leu 
    770                 775                 780                 


Gly Lys Lys Ser Gly Lys Glu Gln Lys Glu Pro Pro Pro Ala Lys Asn 
785                 790                 795                 800 


Glu Pro His Phe Ala His Val Leu Asn Ala Trp Gly Ala Phe Asn Pro 
                805                 810                 815     


Lys Gly Pro Lys Gly Glu Gly Leu Gln Glu Asn Glu Ser Ser Thr Leu 
            820                 825                 830         


Lys Ser Ser Leu Val Thr Val Thr Asp Trp Ser Asp Thr Ser Asp Val 
        835                 840                 845             


<210> 6037
<211> 394
<212> PRT
<213> Homo sapiens

<400> 6037
Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Cys Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Ser Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Val Cys Ser Ser Gln Leu Tyr Gln His Glu Ala Val 
    210                 215                 220                 


Gln Cys Gln Glu Asp Glu Cys Ala Leu Met Leu Leu Glu His Gly Thr 
225                 230                 235                 240 


Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn Thr Thr Leu His Tyr Ala 
                245                 250                 255     


Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys Ala Leu Leu Leu Tyr Gly 
            260                 265                 270         


Ala Asp Ile Glu Ser Lys Asn Lys His Gly Leu Thr Pro Leu Leu Leu 
        275                 280                 285             


Gly Val His Glu Gln Lys Gln Gln Val Val Lys Phe Leu Ile Lys Lys 
    290                 295                 300                 


Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr Gly Arg Thr Ala Leu Ile 
305                 310                 315                 320 


Leu Ala Val Cys Cys Gly Ser Ala Ser Ile Val Ser Leu Leu Leu Glu 
                325                 330                 335     


Gln Asn Ile Asp Val Ser Ser Gln Asp Leu Ser Gly Gln Thr Ala Arg 
            340                 345                 350         


Glu Tyr Ala Val Ser Ser His His His Val Ile Cys Gln Leu Leu Ser 
        355                 360                 365             


Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile Ser Ser Glu Asn Ser Asn 
    370                 375                 380                 


Pro Glu Asn Val Ser Arg Thr Arg Asn Lys 
385                 390                 


<210> 6038
<211> 435
<212> PRT
<213> Homo sapiens

<400> 6038
Met Ala Pro Phe Gly Arg Asn Leu Leu Lys Thr Arg His Lys Asn Arg 
1               5                   10                  15      


Ser Pro Thr Lys Asp Met Asp Ser Glu Glu Lys Glu Ile Val Val Trp 
            20                  25                  30          


Val Cys Gln Glu Glu Lys Leu Val Cys Gly Leu Thr Lys Arg Thr Thr 
        35                  40                  45              


Ser Ala Asp Val Ile Gln Ala Leu Leu Glu Glu His Glu Ala Thr Phe 
    50                  55                  60                  


Gly Glu Lys Arg Phe Leu Leu Gly Lys Pro Ser Asp Tyr Cys Ile Ile 
65                  70                  75                  80  


Glu Lys Trp Arg Gly Ser Glu Arg Val Leu Pro Pro Leu Thr Arg Ile 
                85                  90                  95      


Leu Lys Leu Trp Lys Ala Trp Gly Asp Glu Gln Pro Asn Met Gln Phe 
            100                 105                 110         


Val Leu Val Lys Ala Asp Ala Phe Leu Pro Val Pro Leu Trp Arg Thr 
        115                 120                 125             


Ala Glu Ala Lys Leu Val Gln Asn Thr Glu Lys Leu Trp Glu Leu Ser 
    130                 135                 140                 


Pro Ala Asn Tyr Met Lys Thr Leu Pro Pro Asp Lys Gln Lys Arg Ile 
145                 150                 155                 160 


Val Arg Lys Thr Phe Arg Lys Leu Ala Lys Ile Lys Gln Asp Thr Val 
                165                 170                 175     


Ser His Asp Arg Asp Asn Met Glu Thr Leu Val His Leu Ile Ile Ser 
            180                 185                 190         


Gln Asp His Thr Ile His Gln Gln Val Lys Arg Met Lys Glu Leu Asp 
        195                 200                 205             


Leu Glu Ile Glu Lys Cys Glu Ala Lys Phe His Leu Asp Arg Val Glu 
    210                 215                 220                 


Asn Asp Gly Glu Asn Tyr Val Gln Asp Ala Tyr Leu Met Pro Ser Phe 
225                 230                 235                 240 


Ser Glu Val Glu Gln Asn Leu Asp Leu Gln Tyr Glu Glu Asn Gln Thr 
                245                 250                 255     


Leu Glu Asp Leu Ser Glu Ser Asp Gly Ile Glu Gln Leu Glu Glu Arg 
            260                 265                 270         


Leu Lys Tyr Tyr Arg Ile Leu Ile Asp Lys Leu Ser Ala Glu Ile Glu 
        275                 280                 285             


Lys Glu Val Lys Ser Val Cys Ile Asp Ile Asn Glu Asp Ala Glu Gly 
    290                 295                 300                 


Glu Ala Ala Ser Glu Leu Glu Ser Ser Asn Leu Glu Ser Val Lys Cys 
305                 310                 315                 320 


Asp Leu Glu Lys Ser Met Lys Ala Gly Leu Lys Ile His Ser His Leu 
                325                 330                 335     


Ser Gly Ile Gln Lys Glu Ile Lys Tyr Ser Asp Ser Leu Leu Gln Met 
            340                 345                 350         


Lys Ala Lys Glu Tyr Glu Leu Leu Ala Lys Glu Phe Asn Ser Leu His 
        355                 360                 365             


Ile Ser Asn Lys Asp Gly Cys Gln Leu Lys Glu Asn Arg Ala Lys Glu 
    370                 375                 380                 


Ser Glu Val Pro Ser Ser Asn Gly Glu Ile Pro Pro Phe Thr Gln Arg 
385                 390                 395                 400 


Val Phe Ser Asn Tyr Thr Asn Asp Thr Asp Ser Asp Thr Gly Ile Ser 
                405                 410                 415     


Ser Asn His Ser Gln Asp Ser Glu Thr Thr Val Gly Asp Val Val Leu 
            420                 425                 430         


Leu Ser Thr 
        435 


<210> 6039
<211> 547
<212> PRT
<213> Homo sapiens

<400> 6039
Met Ala Gly Thr Lys Asn Lys Thr Arg Ala Gln Ala Lys Thr Glu Lys 
1               5                   10                  15      


Lys Ala Ala Ile Gln Ala Lys Ala Gly Ala Glu Arg Glu Ala Thr Gly 
            20                  25                  30          


Val Val Arg Pro Val Ala Lys Thr Arg Ala Lys Ala Lys Ala Lys Thr 
        35                  40                  45              


Gly Ser Lys Thr Asp Ala Val Ala Glu Met Lys Ala Val Ser Lys Asn 
    50                  55                  60                  


Lys Val Val Ala Glu Thr Lys Glu Gly Ala Leu Ser Glu Pro Lys Thr 
65                  70                  75                  80  


Leu Gly Lys Ala Met Gly Asp Phe Thr Pro Lys Ala Gly Asn Glu Ser 
                85                  90                  95      


Thr Ser Ser Thr Cys Lys Asn Glu Ala Gly Thr Asp Ala Trp Phe Trp 
            100                 105                 110         


Ala Gly Glu Glu Ala Thr Ile Asn Ser Trp Phe Trp Asn Gly Glu Glu 
        115                 120                 125             


Ala Gly Asn Ser Phe Ser Thr Lys Asn Asp Lys Pro Glu Ile Gly Ala 
    130                 135                 140                 


Gln Val Cys Ala Glu Glu Leu Glu Pro Ala Ala Gly Ala Asp Cys Lys 
145                 150                 155                 160 


Pro Arg Ser Gly Ala Glu Glu Glu Glu Glu Glu Asn Val Ile Gly Asn 
                165                 170                 175     


Trp Phe Trp Glu Gly Asp Asp Thr Ser Phe Asp Pro Asn Pro Lys Pro 
            180                 185                 190         


Val Ser Arg Ile Val Lys Pro Gln Pro Val Tyr Glu Ile Asn Glu Lys 
        195                 200                 205             


Asn Arg Pro Lys Asp Trp Ser Glu Val Thr Ile Trp Pro Asn Ala Pro 
    210                 215                 220                 


Ala Val Thr Pro Ala Val Leu Gly Phe Arg Ser Gln Ala Pro Ser Glu 
225                 230                 235                 240 


Ala Ser Pro Pro Ser Tyr Ile Val Leu Ala Ser Ala Glu Glu Asn Ala 
                245                 250                 255     


Cys Ser Leu Pro Val Ala Thr Ala Cys Arg Pro Ser Arg Asn Thr Arg 
            260                 265                 270         


Ser Cys Ser Gln Pro Ile Pro Glu Cys Arg Phe Asp Ser Asp Pro Cys 
        275                 280                 285             


Ile Gln Thr Ile Asp Glu Ile Arg Arg Gln Ile Arg Ile Arg Glu Val 
    290                 295                 300                 


Asn Gly Ile Lys Pro Phe Ala Cys Pro Cys Lys Met Glu Cys Tyr Met 
305                 310                 315                 320 


Asp Ser Glu Glu Phe Glu Lys Leu Val Ser Leu Leu Lys Ser Thr Thr 
                325                 330                 335     


Asp Pro Leu Ile His Lys Ile Ala Arg Ile Ala Met Gly Val His Asn 
            340                 345                 350         


Val His Pro Phe Ala Gln Glu Phe Ile Asn Glu Val Gly Val Val Thr 
        355                 360                 365             


Leu Ile Glu Ser Leu Leu Ser Phe Pro Ser Pro Glu Met Arg Lys Lys 
    370                 375                 380                 


Thr Val Ile Thr Leu Asn Pro Pro Ser Gly Asp Glu Arg Gln Arg Lys 
385                 390                 395                 400 


Ile Glu Leu His Val Lys His Met Cys Lys Glu Thr Met Ser Phe Pro 
                405                 410                 415     


Leu Asn Ser Pro Gly Gln Gln Ser Gly Leu Lys Ile Leu Gly Gln Leu 
            420                 425                 430         


Thr Thr Asp Phe Val His His Tyr Ile Val Ala Asn Tyr Phe Ser Glu 
        435                 440                 445             


Leu Phe His Leu Leu Ser Ser Gly Asn Cys Lys Thr Arg Asn Leu Val 
    450                 455                 460                 


Leu Lys Leu Leu Leu Asn Met Ser Glu Asn Pro Thr Ala Ala Arg Asp 
465                 470                 475                 480 


Met Ile Asn Met Lys Ala Leu Ala Ala Leu Lys Leu Ile Phe Asn Gln 
                485                 490                 495     


Lys Glu Ala Lys Ala Asn Leu Val Ser Gly Val Ala Ile Phe Ile Asn 
            500                 505                 510         


Ile Lys Glu His Ile Arg Lys Gly Ser Ile Val Val Val Asp His Leu 
        515                 520                 525             


Ser Tyr Asn Thr Leu Met Ala Ile Phe Arg Glu Val Lys Glu Ile Ile 
    530                 535                 540                 


Glu Thr Met 
545         


<210> 6040
<211> 453
<212> PRT
<213> Homo sapiens

<400> 6040
Met Ala Arg Lys Val Val Ser Arg Lys Arg Lys Ala Pro Ala Ser Pro 
1               5                   10                  15      


Gly Ala Gly Ser Asp Ala Gln Gly Pro Gln Phe Gly Trp Asp His Ser 
            20                  25                  30          


Leu His Lys Arg Lys Arg Leu Pro Pro Val Lys Arg Ser Leu Val Tyr 
        35                  40                  45              


Tyr Leu Lys Asn Arg Glu Val Arg Leu Gln Asn Glu Thr Ser Tyr Ser 
    50                  55                  60                  


Arg Val Leu His Gly Tyr Ala Ala Gln Gln Leu Pro Ser Leu Leu Lys 
65                  70                  75                  80  


Glu Arg Glu Phe His Leu Gly Thr Leu Asn Lys Val Phe Ala Ser Gln 
                85                  90                  95      


Trp Leu Asn His Arg Gln Val Val Cys Gly Thr Lys Cys Asn Thr Leu 
            100                 105                 110         


Phe Val Val Asp Val Gln Thr Ser Gln Ile Thr Lys Ile Pro Ile Leu 
        115                 120                 125             


Lys Asp Arg Glu Pro Gly Gly Val Thr Gln Gln Gly Cys Gly Ile His 
    130                 135                 140                 


Ala Ile Glu Leu Asn Pro Ser Arg Thr Leu Leu Ala Thr Gly Gly Asp 
145                 150                 155                 160 


Asn Pro Asn Ser Leu Ala Ile Tyr Arg Leu Pro Thr Leu Asp Pro Val 
                165                 170                 175     


Cys Val Gly Asp Asp Gly His Lys Asp Trp Ile Phe Ser Ile Ala Trp 
            180                 185                 190         


Ile Ser Asp Thr Met Ala Val Ser Gly Ser Arg Asp Gly Ser Met Gly 
        195                 200                 205             


Leu Trp Glu Val Thr Asp Asp Val Leu Thr Lys Ser Asp Ala Arg His 
    210                 215                 220                 


Asn Val Ser Arg Val Pro Val Tyr Ala His Ile Thr His Lys Ala Leu 
225                 230                 235                 240 


Lys Asp Ile Pro Lys Glu Asp Thr Asn Pro Asp Asn Cys Lys Val Arg 
                245                 250                 255     


Ala Leu Ala Phe Asn Asn Lys Asn Lys Glu Leu Gly Ala Val Ser Leu 
            260                 265                 270         


Asp Gly Tyr Phe His Leu Trp Lys Ala Glu Asn Thr Leu Ser Lys Leu 
        275                 280                 285             


Leu Ser Thr Lys Leu Pro Tyr Cys Arg Glu Asn Val Cys Leu Ala Tyr 
    290                 295                 300                 


Gly Ser Glu Trp Ser Val Tyr Ala Val Gly Ser Gln Ala His Val Ser 
305                 310                 315                 320 


Phe Leu Asp Pro Arg Gln Pro Ser Tyr Asn Val Lys Ser Val Cys Ser 
                325                 330                 335     


Arg Glu Arg Gly Ser Gly Ile Arg Ser Val Ser Phe Tyr Glu His Ile 
            340                 345                 350         


Ile Thr Val Gly Thr Gly Gln Gly Ser Leu Leu Phe Tyr Asp Ile Arg 
        355                 360                 365             


Ala Gln Arg Phe Leu Glu Glu Arg Leu Ser Ala Cys Tyr Gly Ser Lys 
    370                 375                 380                 


Pro Arg Leu Ala Gly Glu Asn Leu Lys Leu Thr Thr Gly Lys Gly Trp 
385                 390                 395                 400 


Leu Asn His Asp Glu Thr Trp Arg Asn Tyr Phe Ser Asp Ile Asp Phe 
                405                 410                 415     


Phe Pro Asn Ala Val Tyr Thr His Cys Tyr Asp Ser Ser Gly Thr Lys 
            420                 425                 430         


Leu Phe Val Ala Gly Gly Pro Leu Pro Ser Gly Leu His Gly Asn Tyr 
        435                 440                 445             


Ala Gly Leu Trp Ser 
    450             


<210> 6041
<211> 812
<212> PRT
<213> Homo sapiens

<400> 6041
Met Glu Ala Phe Gln Glu Leu Arg Lys Pro Ser Ala Arg Leu Glu Cys 
1               5                   10                  15      


Asp His Cys Ser Phe Arg Gly Thr Asp Tyr Glu Asn Val Gln Ile His 
            20                  25                  30          


Met Gly Thr Ile His Pro Glu Phe Cys Asp Glu Met Asp Ala Gly Gly 
        35                  40                  45              


Leu Gly Lys Met Ile Phe Tyr Gln Lys Ser Ala Lys Leu Phe His Cys 
    50                  55                  60                  


His Lys Cys Phe Phe Thr Ser Lys Met Tyr Ser Asn Val Tyr Tyr His 
65                  70                  75                  80  


Ile Thr Ser Lys His Ala Ser Pro Asp Lys Trp Asn Asp Lys Pro Lys 
                85                  90                  95      


Asn Gln Leu Asn Lys Glu Thr Asp Pro Val Lys Ser Pro Pro Leu Pro 
            100                 105                 110         


Glu His Gln Lys Ile Pro Cys Asn Ser Ala Glu Pro Lys Ser Ile Pro 
        115                 120                 125             


Ala Leu Ser Met Glu Thr Gln Lys Leu Gly Ser Val Leu Ser Pro Glu 
    130                 135                 140                 


Ser Pro Lys Pro Thr Pro Leu Thr Pro Leu Glu Pro Gln Lys Pro Gly 
145                 150                 155                 160 


Ser Val Val Ser Pro Glu Leu Gln Thr Pro Leu Pro Ser Pro Glu Pro 
                165                 170                 175     


Ser Lys Pro Ala Ser Val Ser Ser Pro Glu Pro Pro Lys Ser Val Pro 
            180                 185                 190         


Val Cys Glu Ser Gln Lys Leu Ala Pro Val Pro Ser Pro Glu Pro Gln 
        195                 200                 205             


Lys Pro Ala Pro Val Ser Pro Glu Ser Val Lys Ala Thr Leu Ser Asn 
    210                 215                 220                 


Pro Lys Pro Gln Lys Gln Ser His Phe Pro Glu Thr Leu Gly Pro Pro 
225                 230                 235                 240 


Ser Ala Ser Ser Pro Glu Ser Pro Val Leu Ala Ala Ser Pro Glu Pro 
                245                 250                 255     


Trp Gly Pro Ser Pro Ala Ala Ser Pro Glu Ser Arg Lys Ser Ala Arg 
            260                 265                 270         


Thr Thr Ser Pro Glu Pro Arg Lys Pro Ser Pro Ser Glu Ser Pro Glu 
        275                 280                 285             


Pro Trp Lys Pro Phe Pro Ala Val Ser Pro Glu Pro Arg Arg Pro Ala 
    290                 295                 300                 


Pro Ala Val Ser Pro Gly Ser Trp Lys Pro Gly Pro Pro Gly Ser Pro 
305                 310                 315                 320 


Arg Pro Trp Lys Ser Asn Pro Ser Ala Ser Ser Gly Pro Trp Lys Pro 
                325                 330                 335     


Ala Lys Pro Ala Pro Ser Val Ser Pro Gly Pro Trp Lys Pro Ile Pro 
            340                 345                 350         


Ser Val Ser Pro Gly Pro Trp Lys Pro Thr Pro Ser Val Ser Ser Ala 
        355                 360                 365             


Ser Trp Lys Ser Ser Ser Val Ser Pro Ser Ser Trp Lys Ser Pro Pro 
    370                 375                 380                 


Ala Ser Pro Glu Ser Trp Lys Ser Gly Pro Pro Glu Leu Arg Lys Thr 
385                 390                 395                 400 


Ala Pro Thr Leu Ser Pro Glu His Trp Lys Ala Val Pro Pro Val Ser 
                405                 410                 415     


Pro Glu Leu Arg Lys Pro Gly Pro Pro Leu Ser Pro Glu Ile Arg Ser 
            420                 425                 430         


Pro Ala Gly Ser Pro Glu Leu Arg Lys Pro Ser Gly Ser Pro Asp Leu 
        435                 440                 445             


Trp Lys Leu Ser Pro Asp Gln Arg Lys Thr Ser Pro Ala Ser Leu Asp 
    450                 455                 460                 


Phe Pro Glu Ser Gln Lys Ser Ser Arg Gly Gly Ser Pro Asp Leu Trp 
465                 470                 475                 480 


Lys Ser Ser Phe Phe Ile Glu Pro Gln Lys Pro Val Phe Pro Glu Thr 
                485                 490                 495     


Arg Lys Pro Gly Pro Ser Gly Pro Ser Glu Ser Pro Lys Ala Ala Ser 
            500                 505                 510         


Asp Ile Trp Lys Pro Val Leu Ser Ile Asp Thr Glu Pro Arg Lys Pro 
        515                 520                 525             


Ala Leu Phe Pro Glu Pro Ala Lys Thr Ala Pro Pro Ala Ser Pro Glu 
    530                 535                 540                 


Ala Arg Lys Arg Ala Leu Phe Pro Glu Pro Arg Lys His Ala Leu Phe 
545                 550                 555                 560 


Pro Glu Leu Pro Lys Ser Ala Leu Phe Ser Glu Ser Gln Lys Ala Val 
                565                 570                 575     


Glu Leu Gly Asp Glu Leu Gln Ile Asp Ala Ile Asp Asp Gln Lys Cys 
            580                 585                 590         


Asp Ile Leu Val Gln Glu Glu Leu Leu Ala Ser Pro Lys Lys Leu Leu 
        595                 600                 605             


Glu Asp Thr Leu Phe Pro Ser Ser Lys Lys Leu Lys Lys Asp Asn Gln 
    610                 615                 620                 


Glu Ser Ser Asp Ala Glu Leu Ser Ser Ser Glu Tyr Ile Lys Thr Asp 
625                 630                 635                 640 


Leu Asp Ala Met Asp Ile Lys Gly Gln Glu Ser Ser Ser Asp Gln Glu 
                645                 650                 655     


Gln Val Asp Val Glu Ser Ile Asp Phe Ser Lys Glu Asn Lys Met Asp 
            660                 665                 670         


Met Thr Ser Pro Glu Gln Ser Arg Asn Val Leu Gln Phe Thr Glu Glu 
        675                 680                 685             


Lys Glu Ala Phe Ile Ser Glu Glu Glu Ile Ala Lys Tyr Met Lys Arg 
    690                 695                 700                 


Gly Lys Gly Lys Tyr Tyr Cys Lys Ile Cys Cys Cys Arg Ala Met Lys 
705                 710                 715                 720 


Lys Gly Ala Val Leu His His Leu Val Asn Lys His Asn Val His Ser 
                725                 730                 735     


Pro Tyr Lys Cys Thr Ile Cys Gly Lys Ala Phe Leu Leu Glu Ser Leu 
            740                 745                 750         


Leu Lys Asn His Val Ala Ala His Gly Gln Ser Leu Leu Lys Cys Pro 
        755                 760                 765             


Arg Cys Asn Phe Glu Ser Asn Phe Pro Arg Gly Phe Lys Lys His Leu 
    770                 775                 780                 


Thr His Cys Gln Ser Arg His Asn Glu Glu Ala Asn Lys Lys Leu Met 
785                 790                 795                 800 


Glu Ala Leu Glu Pro Pro Leu Glu Glu Gln Gln Ile 
                805                 810         


<210> 6042
<211> 657
<212> PRT
<213> Homo sapiens

<400> 6042
Met Asp Glu Gln Glu Ala Leu Asn Ser Ile Met Asn Asp Leu Val Ala 
1               5                   10                  15      


Leu Gln Met Asn Arg Arg His Arg Met Pro Gly Tyr Glu Thr Met Lys 
            20                  25                  30          


Asn Lys Asp Thr Gly His Ser Asn Arg Gln Lys Lys His Asn Ser Ser 
        35                  40                  45              


Ser Ser Ala Leu Leu Asn Ser Pro Thr Val Thr Thr Ser Ser Cys Ala 
    50                  55                  60                  


Gly Ala Ser Glu Lys Lys Lys Phe Leu Ser Asp Val Arg Ile Lys Phe 
65                  70                  75                  80  


Glu His Asn Gly Glu Arg Arg Ile Ile Ala Phe Ser Arg Pro Val Lys 
                85                  90                  95      


Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gln Pro Leu 
            100                 105                 110         


Asp Leu His Tyr Met Asn Asn Glu Leu Ser Ile Leu Leu Lys Asn Gln 
        115                 120                 125             


Asp Asp Leu Asp Lys Ala Ile Asp Ile Leu Asp Arg Ser Ser Ser Met 
    130                 135                 140                 


Lys Ser Leu Arg Ile Leu Leu Leu Ser Gln Asp Arg Asn His Asn Ser 
145                 150                 155                 160 


Ser Ser Pro His Ser Gly Val Ser Arg Gln Val Arg Ile Lys Ala Ser 
                165                 170                 175     


Gln Ser Ala Gly Asp Ile Asn Thr Ile Tyr Gln Pro Pro Glu Pro Arg 
            180                 185                 190         


Ser Arg His Leu Ser Val Ser Ser Gln Asn Pro Gly Arg Ser Ser Pro 
        195                 200                 205             


Pro Pro Gly Tyr Val Pro Glu Arg Gln Gln His Ile Ala Arg Gln Gly 
    210                 215                 220                 


Ser Tyr Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Thr Ser 
225                 230                 235                 240 


Glu Gln Cys Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu Ser 
                245                 250                 255     


Gly Ser Cys Gln Ser Leu Asp Arg Ser Ala Asp Ser Pro Ser Phe Arg 
            260                 265                 270         


Lys Ser Arg Met Ser Arg Ala Gln Ser Phe Pro Asp Asn Arg Gln Glu 
        275                 280                 285             


Tyr Ser Asp Arg Glu Thr Gln Leu Tyr Asp Lys Gly Val Lys Gly Gly 
    290                 295                 300                 


Thr Tyr Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr Ser 
305                 310                 315                 320 


Asp Gly Arg Arg Thr Phe Pro Arg Ile Arg Arg His Gln Gly Asn Leu 
                325                 330                 335     


Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr Asn Gly Glu Asn 
            340                 345                 350         


Met Gly Leu Ala Val Gln Tyr Leu Asp Pro Arg Gly Arg Leu Arg Ser 
        355                 360                 365             


Ala Asp Ser Glu Asn Ala Leu Ser Val Gln Glu Arg Asn Val Pro Thr 
    370                 375                 380                 


Lys Ser Pro Ser Ala Pro Ile Asn Trp Arg Arg Gly Lys Leu Leu Gly 
385                 390                 395                 400 


Gln Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr Gly 
                405                 410                 415     


Arg Glu Leu Ala Ser Lys Gln Val Gln Phe Asp Pro Asp Ser Pro Glu 
            420                 425                 430         


Thr Ser Lys Glu Val Ser Ala Leu Glu Cys Glu Ile Gln Leu Leu Lys 
        435                 440                 445             


Asn Leu Gln His Glu Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg Asp 
    450                 455                 460                 


Arg Ala Glu Lys Thr Leu Thr Ile Phe Met Glu Tyr Met Pro Gly Gly 
465                 470                 475                 480 


Ser Val Lys Asp Gln Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser Val 
                485                 490                 495     


Thr Arg Lys Tyr Thr Arg Gln Ile Leu Glu Gly Met Ser Tyr Leu His 
            500                 505                 510         


Ser Asn Met Ile Val His Arg Asp Ile Lys Gly Ala Asn Ile Leu Arg 
        515                 520                 525             


Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys Arg 
    530                 535                 540                 


Leu Gln Thr Ile Cys Met Ser Gly Thr Gly Met Arg Ser Val Thr Gly 
545                 550                 555                 560 


Thr Pro Tyr Trp Met Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr Gly 
                565                 570                 575     


Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr Val Val Glu Met Leu 
            580                 585                 590         


Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala Ile Phe 
        595                 600                 605             


Lys Ile Ala Thr Gln Pro Thr Asn Pro Gln Leu Pro Ser His Ile Ser 
    610                 615                 620                 


Glu His Gly Arg Asp Phe Leu Arg Arg Ile Phe Val Glu Ala Arg Gln 
625                 630                 635                 640 


Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe Ala Gln Leu Met 
                645                 650                 655     


Tyr 
    


<210> 6043
<211> 848
<212> PRT
<213> Homo sapiens

<400> 6043
Met Gln Ala Glu Ala Ala Asp Trp Phe Ser Ser Met Pro Phe Gln Lys 
1               5                   10                  15      


His Val Tyr Tyr Pro Leu Ala Ser Gly Pro Glu Gly Pro Asp Val Ala 
            20                  25                  30          


Val Ala Ala Ala Ala Ala Gly Ala Ala Ser Met Ala Cys Ala Pro Pro 
        35                  40                  45              


Ser Ala Ala Ser Gly Pro Leu Pro Phe Phe Gln Phe Arg Pro Arg Leu 
    50                  55                  60                  


Glu Ser Val Asp Trp Arg Arg Leu Ser Ala Ile Asp Val Asp Lys Val 
65                  70                  75                  80  


Ala Gly Ala Val Asp Val Leu Thr Leu Gln Glu Asn Ile Met Asn Ile 
                85                  90                  95      


Thr Phe Cys Lys Leu Glu Asp Glu Lys Cys Pro His Cys Gln Ser Gly 
            100                 105                 110         


Val Asp Pro Val Leu Leu Lys Leu Ile Arg Leu Ala Gln Phe Thr Ile 
        115                 120                 125             


Glu Tyr Leu Leu His Ser Gln Glu Phe Leu Thr Ser Gln Leu His Thr 
    130                 135                 140                 


Leu Glu Glu Arg Leu Arg Leu Ser His Cys Asp Gly Glu Gln Ser Lys 
145                 150                 155                 160 


Lys Leu Leu Thr Lys Gln Ala Gly Glu Ile Lys Thr Leu Lys Glu Glu 
                165                 170                 175     


Cys Lys Arg Arg Lys Lys Met Ile Ser Thr Gln Gln Leu Met Ile Glu 
            180                 185                 190         


Ala Lys Ala Asn Tyr Tyr Gln Cys His Phe Cys Asp Lys Ala Phe Met 
        195                 200                 205             


Asn Gln Ala Phe Leu Gln Ser His Ile Gln Arg Arg His Thr Glu Glu 
    210                 215                 220                 


Asn Ser His Phe Glu Tyr Gln Lys Asn Ala Gln Ile Glu Lys Leu Arg 
225                 230                 235                 240 


Ser Glu Ile Val Val Leu Lys Glu Glu Leu Gln Leu Thr Arg Ser Glu 
                245                 250                 255     


Leu Glu Ala Ala His His Ala Ser Ala Val Arg Phe Ser Lys Glu Tyr 
            260                 265                 270         


Glu Met Gln Lys Thr Lys Glu Glu Asp Phe Leu Lys Leu Phe Asp Arg 
        275                 280                 285             


Trp Lys Glu Glu Glu Lys Glu Lys Leu Val Asp Glu Met Glu Lys Val 
    290                 295                 300                 


Lys Glu Met Phe Met Lys Glu Phe Lys Glu Leu Thr Ser Lys Asn Ser 
305                 310                 315                 320 


Ala Leu Glu Tyr Gln Leu Ser Glu Ile Gln Lys Ser Asn Met Gln Ile 
                325                 330                 335     


Lys Ser Asn Ile Gly Thr Leu Lys Asp Ala His Glu Phe Lys Glu Asp 
            340                 345                 350         


Arg Ser Pro Tyr Pro Gln Asp Phe His Asn Val Met Gln Leu Leu Asp 
        355                 360                 365             


Ser Gln Glu Ser Lys Trp Thr Ala Arg Val Gln Ala Ile His Gln Glu 
    370                 375                 380                 


His Lys Lys Glu Lys Gly Arg Leu Leu Ser His Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Thr Ser Met Ile Asp Asp Leu Asn Ala Ser Asn Val Phe Tyr Lys Lys 
                405                 410                 415     


Arg Ile Glu Glu Leu Gly Gln Arg Leu Gln Glu Gln Asn Glu Leu Ile 
            420                 425                 430         


Ile Thr Gln Arg Gln Gln Ile Lys Asp Phe Thr Cys Asn Pro Leu Asn 
        435                 440                 445             


Ser Ile Ser Glu Pro Lys Val Asn Ala Pro Ala Leu His Thr Leu Glu 
    450                 455                 460                 


Thr Lys Ser Ser Leu Pro Met Val His Glu Gln Ala Phe Ser Ser His 
465                 470                 475                 480 


Ile Leu Glu Pro Ile Glu Glu Leu Ser Glu Glu Glu Lys Gly Arg Glu 
                485                 490                 495     


Asn Glu Gln Lys Leu Asn Asn Asn Lys Met His Leu Arg Lys Ala Leu 
            500                 505                 510         


Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met Val Glu Gln 
        515                 520                 525             


Asn Leu Met Glu Lys Leu Glu Thr Leu Gly Ile Asn Ala Asp Ile Arg 
    530                 535                 540                 


Gly Ile Ser Ser Asp Gln Leu His Arg Val Leu Lys Ser Val Glu Ser 
545                 550                 555                 560 


Glu Arg His Lys Gln Glu Arg Glu Ile Pro Asn Phe His Gln Ile Arg 
                565                 570                 575     


Glu Phe Leu Glu His Gln Val Ser Cys Lys Ile Glu Glu Lys Ala Leu 
            580                 585                 590         


Leu Ser Ser Asp Gln Cys Ser Val Ser Gln Met Asp Thr Leu Ser Thr 
        595                 600                 605             


Gly Glu Val Pro Lys Met Ile Gln Leu Pro Ser Lys Asn Arg Gln Leu 
    610                 615                 620                 


Ile Arg Gln Lys Ala Val Ser Thr Asp Arg Thr Ser Val Pro Lys Ile 
625                 630                 635                 640 


Lys Lys Asn Val Met Glu Asp Pro Phe Pro Arg Lys Ser Ser Thr Ile 
                645                 650                 655     


Thr Thr Pro Pro Phe Ser Ser Glu Glu Glu Gln Glu Asp Asp Asp Leu 
            660                 665                 670         


Ile Arg Ala Tyr Ala Ser Pro Gly Pro Leu Pro Val Pro Pro Pro Gln 
        675                 680                 685             


Asn Lys Gly Ser Phe Gly Lys Asn Thr Val Lys Ser Asp Ala Asp Gly 
    690                 695                 700                 


Thr Glu Gly Ser Glu Ile Glu Asp Thr Asp Asp Ser Pro Lys Pro Ala 
705                 710                 715                 720 


Gly Val Ala Val Lys Thr Pro Thr Glu Lys Val Glu Lys Met Phe Pro 
                725                 730                 735     


His Arg Lys Asn Val Asn Lys Pro Val Gly Gly Thr Asn Val Pro Glu 
            740                 745                 750         


Met Phe Ile Lys Lys Glu Glu Leu Gln Glu Leu Lys Cys Ala Asp Val 
        755                 760                 765             


Glu Asp Glu Asp Trp Asp Ile Ser Ser Leu Glu Glu Glu Ile Ser Leu 
    770                 775                 780                 


Gly Lys Lys Ser Gly Lys Glu Gln Lys Glu Pro Pro Pro Ala Lys Asn 
785                 790                 795                 800 


Glu Pro His Phe Ala His Val Leu Asn Ala Trp Gly Ala Phe Asn Pro 
                805                 810                 815     


Lys Gly Pro Lys Gly Glu Gly Leu Gln Glu Asn Glu Ser Ser Thr Leu 
            820                 825                 830         


Lys Ser Ser Leu Val Thr Val Thr Asp Trp Ser Asp Thr Ser Asp Val 
        835                 840                 845             


<210> 6044
<211> 1357
<212> PRT
<213> Homo sapiens

<400> 6044
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Ala Gly Asn Pro Leu Val Gln 
        35                  40                  45              


Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn Pro Ala Pro Gly Leu 
    50                  55                  60                  


Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro Val Gln Val Met Gln 
65                  70                  75                  80  


Asn Ala Asn His Val Thr Ser Ser Pro Val Ala Ser Gln Pro Ile Phe 
                85                  90                  95      


Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val Arg Pro Val Gln Asn 
            100                 105                 110         


Ala Met Asn Gln Val Gly Ile Val Leu Asn Val Gln Gln Gly Gln Thr 
        115                 120                 125             


Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly Thr Gln Phe Val Lys 
    130                 135                 140                 


Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln Met Thr Pro Val Arg 
145                 150                 155                 160 


Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr Asn Thr Phe Thr Thr 
                165                 170                 175     


Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr Val Pro Gln Ser Gln 
            180                 185                 190         


Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser Thr Thr Pro Thr Ala 
        195                 200                 205             


Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val Gln Ser Pro Gly Gln 
    210                 215                 220                 


Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro Ser Phe Pro Ser Pro 
225                 230                 235                 240 


Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val Lys Arg Pro Gly Val 
                245                 250                 255     


Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu Val Asn Thr Leu Asn 
            260                 265                 270         


Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro Val Val Val Ser Asn 
        275                 280                 285             


Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser Gly Pro Glu Ser Ser 
    290                 295                 300                 


Met Lys Val Thr Ser Ser Ile Pro Val Phe Asp Leu Gln Asp Gly Gly 
305                 310                 315                 320 


Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln Phe Arg Val Thr Glu Ala 
                325                 330                 335     


Leu Arg Gly His Met Cys Tyr Cys Cys Pro Glu Met Val Glu Tyr Gln 
            340                 345                 350         


Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro Ser Val Pro Ser Ala Ala 
        355                 360                 365             


Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro Val Ala Ser Thr Pro Ser 
    370                 375                 380                 


Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro Thr Lys Val Pro Glu Pro 
385                 390                 395                 400 


Asn Glu Asn Val Gly Asp Ala Val Gln Thr Lys Leu Ile Met Leu Val 
                405                 410                 415     


Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly Lys Val Ala Gln Leu Thr 
            420                 425                 430         


Asn Phe Pro Lys Val Ala Thr Ser Phe Arg Cys Pro His Cys Thr Lys 
        435                 440                 445             


Arg Leu Lys Asn Asn Ile Arg Phe Met Asn His Met Lys His His Val 
    450                 455                 460                 


Glu Leu Asp Gln Gln Asn Gly Glu Val Asp Gly His Thr Ile Cys Gln 
465                 470                 475                 480 


His Cys Tyr Arg Gln Phe Ser Thr Pro Phe Gln Leu Gln Cys His Leu 
                485                 490                 495     


Glu Asn Val His Ser Pro Tyr Glu Ser Thr Thr Lys Cys Lys Ile Cys 
            500                 505                 510         


Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe Leu Gln His Met Lys Asp 
        515                 520                 525             


Thr His Lys Pro Gly Glu Met Pro Tyr Val Cys Gln Val Cys Gln Tyr 
    530                 535                 540                 


Arg Ser Ser Leu Tyr Ser Glu Val Asp Val His Phe Arg Met Ile His 
545                 550                 555                 560 


Glu Asp Thr Arg His Leu Leu Cys Pro Tyr Cys Leu Lys Val Phe Lys 
                565                 570                 575     


Asn Gly Asn Ala Phe Gln Gln His Tyr Met Arg His Gln Lys Arg Asn 
            580                 585                 590         


Val Tyr His Cys Asn Lys Cys Arg Leu Gln Phe Leu Phe Ala Lys Asp 
        595                 600                 605             


Lys Ile Glu His Lys Leu Gln His His Lys Thr Phe Arg Lys Pro Lys 
    610                 615                 620                 


Gln Leu Glu Gly Leu Lys Pro Gly Thr Lys Val Thr Ile Arg Ala Ser 
625                 630                 635                 640 


Arg Gly Gln Pro Arg Thr Val Pro Val Ser Ser Asn Asp Thr Pro Pro 
                645                 650                 655     


Ser Ala Leu Gln Glu Ala Ala Pro Leu Thr Ser Ser Met Asp Pro Leu 
            660                 665                 670         


Pro Val Phe Leu Tyr Pro Pro Val Gln Arg Ser Ile Gln Lys Arg Ala 
        675                 680                 685             


Val Arg Lys Met Ser Val Met Gly Arg Gln Thr Cys Leu Glu Cys Ser 
    690                 695                 700                 


Phe Glu Ile Pro Asp Phe Pro Asn His Phe Pro Thr Tyr Val His Cys 
705                 710                 715                 720 


Ser Leu Cys Arg Tyr Ser Thr Cys Cys Ser Arg Ala Tyr Ala Asn His 
                725                 730                 735     


Met Ile Asn Asn His Val Pro Arg Lys Ser Pro Lys Tyr Leu Ala Leu 
            740                 745                 750         


Phe Lys Asn Ser Val Ser Gly Ile Lys Leu Ala Cys Thr Ser Cys Thr 
        755                 760                 765             


Phe Val Thr Ser Val Gly Asp Ala Met Ala Lys His Leu Val Phe Asn 
    770                 775                 780                 


Pro Ser His Arg Ser Ser Ser Ile Leu Pro Arg Gly Leu Thr Trp Ile 
785                 790                 795                 800 


Ala His Ser Arg His Gly Gln Thr Arg Asp Arg Val His Asp Arg Asn 
                805                 810                 815     


Val Lys Asn Met Tyr Pro Pro Pro Ser Phe Pro Thr Asn Lys Ala Ala 
            820                 825                 830         


Thr Val Lys Ser Ala Gly Ala Thr Pro Ala Glu Pro Glu Glu Leu Leu 
        835                 840                 845             


Thr Pro Leu Ala Pro Ala Leu Pro Ser Pro Ala Ser Thr Ala Thr Pro 
    850                 855                 860                 


Pro Pro Thr Pro Thr His Pro Gln Ala Leu Ala Leu Pro Pro Leu Ala 
865                 870                 875                 880 


Thr Glu Gly Ala Glu Cys Leu Asn Val Asp Asp Gln Asp Glu Gly Ser 
                885                 890                 895     


Pro Val Thr Gln Glu Pro Glu Leu Ala Ser Gly Gly Gly Gly Ser Gly 
            900                 905                 910         


Gly Val Gly Lys Lys Glu Gln Leu Ser Val Lys Lys Leu Arg Val Val 
        915                 920                 925             


Leu Phe Ala Leu Cys Cys Asn Thr Glu Gln Ala Ala Glu His Phe Arg 
    930                 935                 940                 


Asn Pro Gln Arg Arg Ile Arg Arg Trp Leu Arg Arg Phe Gln Ala Ser 
945                 950                 955                 960 


Gln Gly Glu Asn Leu Glu Gly Lys Tyr Leu Ser Phe Glu Ala Glu Glu 
                965                 970                 975     


Lys Leu Ala Glu Trp Val Leu Thr Gln Arg Glu Gln Gln Leu Pro Val 
            980                 985                 990         


Asn Glu Glu Thr Leu Phe Gln Lys  Ala Thr Lys Ile Gly  Arg Ser Leu 
        995                 1000                 1005             


Glu Gly  Gly Phe Lys Ile Ser  Tyr Glu Trp Ala Val  Arg Phe Met 
    1010                 1015                 1020             


Leu Arg  His His Leu Thr Pro  His Ala Arg Arg Ala  Val Ala His 
    1025                 1030                 1035             


Thr Leu  Pro Lys Asp Val Ala  Glu Asn Ala Gly Leu  Phe Ile Asp 
    1040                 1045                 1050             


Phe Val  Gln Arg Gln Ile His  Asn Gln Asp Leu Pro  Leu Ser Met 
    1055                 1060                 1065             


Ile Val  Ala Ile Asp Glu Ile  Ser Leu Phe Leu Asp  Thr Glu Val 
    1070                 1075                 1080             


Leu Ser  Ser Asp Asp Arg Lys  Glu Asn Ala Leu Gln  Thr Val Gly 
    1085                 1090                 1095             


Thr Gly  Glu Pro Trp Cys Asp  Val Val Leu Ala Ile  Leu Ala Asp 
    1100                 1105                 1110             


Gly Thr  Val Leu Pro Thr Leu  Val Phe Tyr Arg Gly  Gln Met Asp 
    1115                 1120                 1125             


Gln Pro  Ala Asn Met Pro Asp  Ser Ile Leu Leu Glu  Ala Lys Glu 
    1130                 1135                 1140             


Ser Gly  Tyr Ser Asp Asp Glu  Ile Met Glu Leu Trp  Ser Thr Arg 
    1145                 1150                 1155             


Val Trp  Gln Lys His Thr Ala  Cys Gln Arg Ser Lys  Gly Met Leu 
    1160                 1165                 1170             


Val Met  Asp Cys His Arg Thr  His Leu Ser Glu Glu  Val Leu Ala 
    1175                 1180                 1185             


Met Leu  Ser Ala Ser Ser Thr  Leu Pro Ala Val Val  Pro Ala Gly 
    1190                 1195                 1200             


Cys Ser  Ser Lys Ile Gln Pro  Leu Asp Val Cys Ile  Lys Arg Thr 
    1205                 1210                 1215             


Val Lys  Asn Phe Leu His Lys  Lys Trp Lys Glu Gln  Ala Arg Glu 
    1220                 1225                 1230             


Met Ala  Asp Thr Ala Cys Asp  Ser Asp Val Leu Leu  Gln Leu Val 
    1235                 1240                 1245             


Leu Val  Trp Leu Gly Glu Val  Leu Gly Val Ile Gly  Asp Cys Pro 
    1250                 1255                 1260             


Glu Leu  Val Gln Arg Ser Phe  Leu Val Ala Ser Val  Leu Pro Gly 
    1265                 1270                 1275             


Pro Asp  Gly Asn Ile Asn Ser  Pro Thr Arg Asn Ala  Asp Met Gln 
    1280                 1285                 1290             


Glu Glu  Leu Ile Ala Ser Leu  Glu Glu Gln Leu Lys  Leu Ser Gly 
    1295                 1300                 1305             


Glu His  Ser Glu Ser Ser Thr  Pro Arg Pro Arg Ser  Ser Pro Glu 
    1310                 1315                 1320             


Glu Thr  Ile Glu Pro Glu Ser  Leu His Gln Leu Phe  Glu Gly Glu 
    1325                 1330                 1335             


Ser Glu  Thr Glu Ser Phe Tyr  Gly Phe Glu Glu Ala  Asp Leu Asp 
    1340                 1345                 1350             


Leu Met  Glu Ile 
    1355         


<210> 6045
<211> 967
<212> PRT
<213> Homo sapiens

<400> 6045
Met Gly Pro Gly Gln Pro Ala Ser Thr Cys Val His Leu Ala Pro Arg 
1               5                   10                  15      


Thr Gln Leu Asp Gly Arg Ser Asp Pro Lys Val Leu Gln Thr Gln Asn 
            20                  25                  30          


Gln Leu Gln Phe Asn Arg Asn Val Pro Thr His Ser Ser Asn Leu Ala 
        35                  40                  45              


Ile Arg Tyr Ser Cys Pro His Ala Ile Arg Ile Glu Lys Leu Lys His 
    50                  55                  60                  


Ser Tyr Asn Glu Ser Tyr His Cys Lys Asp Ala Asp Cys Arg Val Gly 
65                  70                  75                  80  


Pro Asp Leu Gly Ser Ser Val Ser Phe Ser Val Ile Ser Gln Glu Arg 
                85                  90                  95      


Leu Ser Tyr Ala Val His Leu Ala Arg Arg Asp Val Lys Arg Arg Gln 
            100                 105                 110         


Phe Glu Lys His Ile Lys Glu His His Leu Arg Ser Gln Pro Gln Ser 
        115                 120                 125             


Ser Gln Lys Cys Gly His Thr Lys Tyr Lys Ile Pro Asp His Arg Val 
    130                 135                 140                 


Glu Arg Lys Glu Ser Lys Ser Gln Ala Ala Cys Gln Cys Ser His Gln 
145                 150                 155                 160 


Pro Ser Lys Val Glu Ile Ser Ser Ser Gly Ala Lys Val Tyr Leu Tyr 
                165                 170                 175     


Ser Ser His Pro Gly Gln Ser Asp Leu Thr Val Pro Asn Ser Pro Pro 
            180                 185                 190         


Thr His Asp Pro Gly Leu Gln Pro His Pro Arg Ile Gly Asp His Lys 
        195                 200                 205             


Asn Ile Ser Glu Gln Lys Ser Leu Leu Glu Val Gln Arg Leu Gln Lys 
    210                 215                 220                 


Glu Leu Ser Ser Cys Ile His Lys Ile Glu Glu Val Thr Lys Lys Asp 
225                 230                 235                 240 


Arg Leu Glu Glu Ala Leu Asp Pro Asp Glu Glu Arg Arg Ile Arg Ile 
                245                 250                 255     


Arg Arg Gln Glu Gln Ala Ala Arg Ser Ala Arg Met Leu Tyr Val Leu 
            260                 265                 270         


Gln Gln Gln Val Lys Glu Ile Gln Glu Glu Leu Asp Lys Leu Ser Pro 
        275                 280                 285             


His Lys Ile Lys His Thr Lys Lys Ser Trp Ala Met Ser Lys Leu Ala 
    290                 295                 300                 


Ala Ala His Arg Gly Ala Ile Arg Ala Leu Gln Met Phe Val Thr Gln 
305                 310                 315                 320 


Phe Thr Asp Arg Gly Glu His Pro Leu Pro Ala Arg Cys Lys Glu Leu 
                325                 330                 335     


Gly Ser Leu Ile Arg Gln Leu Ser Leu Cys Ser Val Lys Leu Asp Ala 
            340                 345                 350         


Asp Pro Ser Val Pro Asp Val Val Ile Asp Ile Leu Gln Gln Ile Glu 
        355                 360                 365             


Ala Leu Glu Ser Leu Leu Glu Lys Lys Leu Ser Pro Lys Lys Val Lys 
    370                 375                 380                 


Lys Cys Phe Ser Glu Ile Arg Ser Arg Phe Pro Ile Gly Ser Gln Lys 
385                 390                 395                 400 


Ala Leu Glu Arg Trp Pro Ser Thr Ser Pro Lys Gly Glu Arg Arg Pro 
                405                 410                 415     


Leu Thr Ala Lys Asp Thr Phe Pro Gln Glu Thr Ser Arg Pro Ser Val 
            420                 425                 430         


Ala Lys Gln Leu Leu Ala Asp Lys Tyr Gln Pro Asp Thr Glu Leu Pro 
        435                 440                 445             


Glu Thr Gln Arg Leu Gln Ser Glu Leu Asp Val Leu Asp Ala Asp Ile 
    450                 455                 460                 


Val Leu Glu Glu Gly Pro Phe Ile Leu Asp Gln Ser Ala Ser Phe Lys 
465                 470                 475                 480 


Asp Glu Val Leu Ala Val Ala Lys Thr Lys Ala Gly Lys Lys Lys Pro 
                485                 490                 495     


Val Thr Glu Asn Val Pro Phe Arg Lys Lys Asp Thr Leu Ala Pro Ala 
            500                 505                 510         


Arg Gln Gln Gly Leu Arg Lys Ala Glu Arg Gly Arg Gln Ser Gln Pro 
        515                 520                 525             


His Ser Lys Ser Arg Val Gln Gln Thr Thr Val Ser Ser Arg Leu Lys 
    530                 535                 540                 


Met Asn Arg Gln Pro Val Lys Asp Arg Lys Ala Pro Trp Ile Pro Pro 
545                 550                 555                 560 


Asn Pro Thr Ser Pro Pro Ala Ser Pro Lys Cys Ala Ala Trp Leu Lys 
                565                 570                 575     


Val Lys Thr Ser Pro Arg Asp Ala Thr Lys Glu Pro Leu Gln Gln Glu 
            580                 585                 590         


Asp Pro Gln Glu Glu Ser His Leu Thr Gly Ala Val Glu His Glu Ala 
        595                 600                 605             


Ala Arg Leu Ala Trp Leu Asp Ala Glu Thr Ser Lys Arg Leu Lys Glu 
    610                 615                 620                 


Leu Glu Glu Leu Lys Ala Lys Glu Ile Asp Ser Met Gln Lys Gln Arg 
625                 630                 635                 640 


Leu Asp Trp Leu Asp Ala Glu Thr Ser Arg Arg Thr Lys Glu Leu Asn 
                645                 650                 655     


Glu Leu Lys Ala Glu Glu Met Tyr Arg Leu Gln Gln Leu Ser Val Ser 
            660                 665                 670         


Ala Thr His Leu Ala Asp Lys Val Glu Glu Ala Val Leu Asp Arg Leu 
        675                 680                 685             


Lys Pro Leu Leu Val Lys Ala Gln Arg Val Asn Ser Thr Thr Glu Ala 
    690                 695                 700                 


Asn Ile His Leu Lys Asp Gly Ser Ser Val Asn Thr Ala Lys Ala Gln 
705                 710                 715                 720 


Pro Ala Gln Glu Val Ala Ala Val Asp Phe Glu Ser Asn Asn Ile Arg 
                725                 730                 735     


Gln Leu Asp Asp Phe Leu Glu Asp Cys Ala Ser Glu Leu Trp Ala Val 
            740                 745                 750         


Thr His Ala Lys Ile Leu Gly Ser Glu Thr Leu Ala Thr Val Glu Asp 
        755                 760                 765             


Ser Lys Asp Ser Pro Asp Leu Glu Ile Met Met Arg Arg Met Glu Glu 
    770                 775                 780                 


Met Glu Lys Tyr Gln Glu Ser Val Arg Gln Arg Tyr Asn Lys Ile Ala 
785                 790                 795                 800 


Tyr Ala Asp Pro Arg Leu Trp Met Gln Glu Glu Asn Asn Asp Gln Lys 
                805                 810                 815     


Ile Ser Ala Ile Ser Glu Lys Pro Leu Ser Pro His Pro Ile Arg Ile 
            820                 825                 830         


Thr Lys Thr Val Asp Arg Lys Asp Pro Ala Val Asn Ile Met Leu Glu 
        835                 840                 845             


Arg Pro Cys Asn Gly Asn Ser Leu Asp Glu Ser Val Gly Thr Glu Glu 
    850                 855                 860                 


Gly Ser Glu Lys Arg Glu Ala Pro Leu Leu Ser Leu Ala Glu Asp Ser 
865                 870                 875                 880 


Gln Gln Lys Glu Gly Arg Ala Pro Leu Phe Val Pro Pro Gly Met Gln 
                885                 890                 895     


His Ser Ile Gly Asp Tyr Cys Ser Arg Phe Glu Gln Tyr Leu Arg Ile 
            900                 905                 910         


Ile Ser His Glu Ala Val Gly Ser Phe Asn Pro Trp Leu Ile Ala Glu 
        915                 920                 925             


Ser Phe Ser Glu Glu Leu Val Asp Glu Ala Leu Gly Ala Val Ala Ala 
    930                 935                 940                 


Glu Leu Gln Asp Met Cys Glu Asp Tyr Ala Glu Ala Val Phe Thr Ser 
945                 950                 955                 960 


Glu Phe Leu Glu Ala Ala Thr 
                965         


<210> 6046
<211> 2279
<212> PRT
<213> Homo sapiens

<400> 6046
Met Tyr Arg Ser Ser Ala Arg Ser Ser Val Ser Ser His Arg Pro Lys 
1               5                   10                  15      


Asp Asp Gly Gly Gly Gly Pro Arg Ser Gly Arg Ser Ser Gly Ser Ser 
            20                  25                  30          


Ser Gly Pro Ala Arg Arg Ser Ser Pro Pro Pro Pro Pro Ser Gly Ser 
        35                  40                  45              


Ser Ser Arg Thr Pro Ala Arg Arg Pro Arg Ser Pro Ser Gly His Arg 
    50                  55                  60                  


Gly Arg Arg Ala Ser Pro Ser Pro Pro Arg Gly Arg Arg Val Ser Pro 
65                  70                  75                  80  


Ser Pro Pro Arg Ala Arg Arg Gly Ser Pro Ser Pro Pro Arg Gly Arg 
                85                  90                  95      


Arg Leu Phe Pro Pro Gly Pro Ala Gly Phe Arg Gly Ser Ser Arg Gly 
            100                 105                 110         


Glu Ser Arg Ala Asp Tyr Ala Arg Asp Gly Arg Gly Asp His Pro Gly 
        115                 120                 125             


Asp Ser Gly Ser Arg Arg Arg Ser Pro Gly Leu Cys Ser Asp Ser Leu 
    130                 135                 140                 


Glu Lys Ser Leu Arg Ile Thr Val Gly Asn Asp His Phe Cys Val Ser 
145                 150                 155                 160 


Thr Pro Glu Arg Arg Arg Leu Ser Asp Arg Leu Gly Ser Pro Val Asp 
                165                 170                 175     


Asn Leu Glu Asp Met Asp Arg Asp Asp Leu Thr Asp Asp Ser Val Phe 
            180                 185                 190         


Thr Arg Ser Ser Gln Cys Ser Arg Gly Leu Glu Arg Tyr Ile Ser Gln 
        195                 200                 205             


Glu Glu Gly Pro Leu Ser Pro Phe Leu Gly Gln Leu Asp Glu Asp Tyr 
    210                 215                 220                 


Arg Thr Lys Glu Thr Phe Leu His Arg Ser Asp Tyr Ser Pro His Ile 
225                 230                 235                 240 


Ser Cys His Asp Glu Leu Leu Arg Gly Thr Glu Arg Asn Arg Glu Lys 
                245                 250                 255     


Leu Lys Gly Tyr Ser Ile Arg Ser Glu Glu Arg Ser Arg Glu Ala Lys 
            260                 265                 270         


Arg Pro Arg Tyr Asp Asp Thr Val Lys Ile Asn Ser Met Gly Gly Asp 
        275                 280                 285             


His Pro Ser Phe Thr Ser Gly Thr Arg Asn Tyr Arg Gln Arg Arg Arg 
    290                 295                 300                 


Ser Pro Ser Pro Arg Phe Leu Asp Pro Glu Phe Arg Glu Leu Asp Leu 
305                 310                 315                 320 


Ala Arg Arg Lys Arg Glu Glu Glu Glu Glu Arg Ser Arg Ser Leu Ser 
                325                 330                 335     


Gln Glu Leu Val Gly Val Asp Gly Gly Gly Thr Gly Cys Ser Ile Pro 
            340                 345                 350         


Gly Leu Ser Gly Val Leu Thr Ala Ser Glu Pro Gly Tyr Ser Leu His 
        355                 360                 365             


Arg Pro Glu Glu Val Ser Val Met Pro Lys Lys Ser Ile Leu Lys Lys 
    370                 375                 380                 


Arg Ile Glu Val Asp Ile Met Glu Pro Ser Met Gln Leu Glu Ser Phe 
385                 390                 395                 400 


Ser Ser Ser Thr Ser Ser Ser Gln Asp His Pro Leu Tyr Ser Gly His 
                405                 410                 415     


Pro Ser Leu Pro Leu Ser Gly Ala Ile Ala Ala Phe Ala Ser Glu Ile 
            420                 425                 430         


Glu Asn Lys Gly Thr Met Val Glu Thr Ala Leu Lys Glu Pro Gln Gly 
        435                 440                 445             


Asn Leu Tyr Gln Trp Gly Pro Leu Pro Gly Ile Pro Lys Asp Asn Ser 
    450                 455                 460                 


Pro Leu Arg Glu Lys Phe Gly Ser Phe Leu Cys His Lys Asp Asn Leu 
465                 470                 475                 480 


Asp Leu Lys Ala Glu Gly Pro Glu Arg His Thr Asp Phe Leu Leu Pro 
                485                 490                 495     


His Glu Arg Ala Ser Gln Asp Gly Ser Gly Phe Ser Arg Ile Leu Ser 
            500                 505                 510         


Met Leu Ala Asp Ser Thr Ser Thr Gln Glu Lys Arg Arg Arg Ser Phe 
        515                 520                 525             


Pro Asp Ile Glu Asp Glu Glu Lys Phe Leu Tyr Gly Asp Glu Glu Glu 
    530                 535                 540                 


Asp Leu Lys Ala Glu Ser Val Pro Lys Pro Leu Gly Ser Ser Glu Ser 
545                 550                 555                 560 


Glu Val Met Arg Gln Lys Ala Ser Ser Leu Pro Ser Ser Ala Pro Ala 
                565                 570                 575     


Val Lys Leu Glu Ser Leu Glu Glu Thr Asn Pro Glu Tyr Ala Lys Ile 
            580                 585                 590         


His Asp Leu Leu Lys Thr Ile Gly Leu Asp Ile Gly Val Ala Glu Ile 
        595                 600                 605             


Ser Gln Leu Ala Ala Arg Thr Gln Glu Arg Leu His Gly Lys Lys Pro 
    610                 615                 620                 


Ser Leu Arg Ser Ser Ala Asp Arg Arg Ser Ser Val Asp Arg Tyr Phe 
625                 630                 635                 640 


Ser Ala Asp His Cys Ser Ser Val Asp His Arg Phe Ser Ala Asp Arg 
                645                 650                 655     


Cys Ser Ser Val Asp His Cys Phe Ser Ala Asp Arg Arg Ser Ser Asp 
            660                 665                 670         


Pro His Arg Leu Glu Ser Arg Glu Ala His His Ser Asn Thr His Ser 
        675                 680                 685             


Pro Glu Val Ser His Pro His Pro Pro Ser Pro Val Asp Pro Tyr Leu 
    690                 695                 700                 


Leu Thr Lys Asn Ser Pro Pro Phe Leu Lys Ser Asp His Pro Val Gly 
705                 710                 715                 720 


His Ile Ser Gly Pro Glu Val Val Gly Ser Gly Phe Gln Ser Ser Val 
                725                 730                 735     


Ala Val Arg Cys Met Leu Pro Ser Ala Pro Ser Ala Pro Ile Arg Leu 
            740                 745                 750         


Pro His Thr Ala Ala Leu Ser Gln Phe His Met Pro Arg Ala Ser Gln 
        755                 760                 765             


Phe Ala Ala Ala Arg Ile Pro Pro Asn Tyr Gln Gly Pro Ala Ile Pro 
    770                 775                 780                 


Pro Ala Ser Phe Asp Ala Tyr Arg His Tyr Met Ala Tyr Ala Ala Ser 
785                 790                 795                 800 


Arg Trp Pro Met Tyr Pro Thr Ser Gln Pro Ser Asn His Pro Val Pro 
                805                 810                 815     


Glu Pro His Arg Ile Met Pro Ile Thr Lys Gln Ala Thr Arg Ser Arg 
            820                 825                 830         


Pro Asn Leu Arg Val Ile Pro Thr Val Thr Pro Asp Lys Pro Lys Gln 
        835                 840                 845             


Lys Glu Ser Leu Arg Gly Ser Ile Pro Ala Ala Gln Val Pro Val Gln 
    850                 855                 860                 


Val Ser Ile Pro Ser Leu Ile Arg Tyr Asn Pro Glu Lys Ile Ser Asp 
865                 870                 875                 880 


Glu Lys Asn Arg Ala Ser Gln Lys Gln Lys Val Ile Glu Glu Arg Glu 
                885                 890                 895     


Lys Leu Lys Asn Asp Arg Glu Ala Arg Gln Lys Lys Met Tyr Tyr Leu 
            900                 905                 910         


Arg Thr Glu Leu Glu Arg Leu His Lys Gln Gln Gly Glu Met Leu Arg 
        915                 920                 925             


Lys Lys Arg Arg Glu Lys Asp Gly His Lys Asp Pro Leu Leu Val Glu 
    930                 935                 940                 


Val Ser Arg Leu Gln Asp Asn Ile Met Lys Asp Ile Ala Glu Leu Arg 
945                 950                 955                 960 


Gln Glu Ala Glu Glu Ala Glu Lys Lys Gln Ser Glu Leu Asp Lys Val 
                965                 970                 975     


Ala Gln Ile Leu Gly Ile Asn Ile Phe Asp Lys Ser Gln Lys Ser Leu 
            980                 985                 990         


Ser Asp Ser Arg Glu Pro Thr Glu  Lys Pro Gly Lys Ala  Glu Lys Ser 
        995                 1000                 1005             


Lys Ser  Pro Glu Lys Val Ser  Ser Phe Ser Asn Ser  Ser Ser Asn 
    1010                 1015                 1020             


Lys Glu  Ser Lys Val Asn Asn  Glu Lys Phe Arg Thr  Lys Ser Pro 
    1025                 1030                 1035             


Lys Pro  Ala Glu Ser Pro Gln  Ser Ala Thr Lys Gln  Leu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Ala Ala Tyr Glu Tyr  Tyr Asp Ala Gly Asn  His Trp Cys 
    1055                 1060                 1065             


Lys Asp  Cys Asn Thr Ile Cys  Gly Thr Met Phe Asp  Phe Phe Thr 
    1070                 1075                 1080             


His Met  His Asn Lys Lys His  Thr Gln Thr Leu Asp  Pro Tyr Asn 
    1085                 1090                 1095             


Arg Pro  Trp Ala Ser Lys Thr  Gln Ser Glu Ala Lys  Gln Asp Ala 
    1100                 1105                 1110             


Ile Lys  Arg Thr Asp Lys Ile  Thr Val Pro Ala Lys  Gly Ser Glu 
    1115                 1120                 1125             


Phe Leu  Val Pro Ile Ser Gly  Phe Tyr Cys Gln Leu  Cys Glu Glu 
    1130                 1135                 1140             


Phe Leu  Gly Asp Pro Ile Ser  Gly Glu Gln His Val  Lys Gly His 
    1145                 1150                 1155             


Gln His  Asn Glu Lys Tyr Lys  Lys Tyr Val Asp Glu  Asn Pro Leu 
    1160                 1165                 1170             


Tyr Glu  Glu Arg Arg Asn Leu  Asp Arg Gln Ala Gly  Leu Ala Val 
    1175                 1180                 1185             


Val Leu  Glu Thr Glu Arg Arg  Arg Gln Ser Glu Leu  Lys Arg Lys 
    1190                 1195                 1200             


Leu Ser  Glu Lys Pro Lys Glu  Glu Lys Lys Glu Lys  Lys Ala Lys 
    1205                 1210                 1215             


Ala Val  Lys Glu Val Lys Glu  Asp Asp Lys Val Ser  Glu Lys Leu 
    1220                 1225                 1230             


Glu Asp  Gln Leu Ser Glu Gly  Arg Asn Ser Pro Glu  Lys Ala Glu 
    1235                 1240                 1245             


Asn Lys  Arg Asn Thr Gly Ile  Lys Leu Gln Leu Lys  Glu Glu Val 
    1250                 1255                 1260             


Lys Lys  Glu Ser Pro Thr Ser  Ser Ser Phe Gly Lys  Phe Ser Trp 
    1265                 1270                 1275             


Lys Lys  Pro Glu Lys Glu Glu  Glu Lys Ser Ser Leu  Val Thr Pro 
    1280                 1285                 1290             


Ser Ile  Ser Lys Glu Glu Ile  Leu Glu Ser Ser Lys  Asp Lys Glu 
    1295                 1300                 1305             


Asp Gly  Lys Thr Glu Ala Gly  Lys Ala Lys Pro Ile  Lys Ile Lys 
    1310                 1315                 1320             


Leu Ser  Gly Lys Thr Val Val  Ala His Thr Ser Pro  Trp Met Pro 
    1325                 1330                 1335             


Val Val  Thr Thr Ser Thr Gln  Thr Lys Ile Arg Pro  Asn Leu Pro 
    1340                 1345                 1350             


Ile Pro  Ser Thr Val Leu Arg  Lys Ser Cys Ser Ala  Thr Met Ser 
    1355                 1360                 1365             


Lys Pro  Ala Pro Leu Asn Thr  Phe Leu Ser Ile Lys  Ser Ser Gly 
    1370                 1375                 1380             


Thr Thr  Ala Lys Pro Leu Pro  Val Val Lys Glu Ser  Ser Ala Asp 
    1385                 1390                 1395             


Leu Leu  Leu Pro Pro Asp Ile  Ile Ser Lys Ala Phe  Gly Gly Glu 
    1400                 1405                 1410             


Glu Val  Ile Leu Lys Gly Ser  Pro Glu Glu Lys Val  Val Leu Ala 
    1415                 1420                 1425             


Glu Lys  Ser Glu Pro Ser His  Leu Pro Glu Gln Ile  Leu Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Val Ile 
    1445                 1450                 1455             


Pro His  Pro Ala Ala Pro Ser  Ala Ala Gln Ala Asn  Ala Ile Leu 
    1460                 1465                 1470             


Ala Pro  Val Lys Ser Asn Pro  Val Val Ser Gln Thr  Leu Ser Pro 
    1475                 1480                 1485             


Gly Phe  Val Gly Pro Asn Ile  Leu Asn Pro Val Leu  Pro Val Ala 
    1490                 1495                 1500             


Ile Met  Ala Ser Ala Gln Pro  Ala Ala Ile Pro Ser  Asp Glu Thr 
    1505                 1510                 1515             


Ala Pro  Gly Val Ser Glu Ser  Asp Arg Asp Gln Thr  Leu Phe Ser 
    1520                 1525                 1530             


Val Leu  Val Arg Pro Pro Pro  Pro Leu Ser Ser Val  Phe Ser Glu 
    1535                 1540                 1545             


Gln Ala  Lys Lys Leu Glu Lys  Arg Asn Ser Cys Leu  Ala Thr Ala 
    1550                 1555                 1560             


Asn Ala  Lys Asp Leu Tyr Asp  Ile Phe Tyr Ser Ser  Gly Gly Lys 
    1565                 1570                 1575             


Gly Ala  Pro Glu Thr Lys Gly  Ala Pro Glu Thr Lys  Leu Ser Gly 
    1580                 1585                 1590             


Gly Pro  Leu Ala Asn Gly Glu  Asn Ser Asn Leu Ser  Arg Thr Lys 
    1595                 1600                 1605             


Ser Ser  Asp Thr Ser Ser Thr  Ser Pro Leu Asn Ser  Ser Ala Ser 
    1610                 1615                 1620             


Gln Glu  Glu Leu His Gln Asp  Glu Gly Leu Val Ala  Ala Pro Ile 
    1625                 1630                 1635             


Val Ser  Asn Ser Glu Lys Pro  Ile Ala Lys Thr Leu  Val Ala Leu 
    1640                 1645                 1650             


Gly Lys  Trp Ser Val Val Glu  His Val Gly Pro Lys  Ser Thr Gly 
    1655                 1660                 1665             


Ser Thr  Tyr Gly Phe Leu Gln  Pro Leu Thr Arg Leu  Cys Gln Ser 
    1670                 1675                 1680             


Arg Pro  Tyr Glu Thr Ile Thr  Pro Lys Thr Asp Thr  Leu Ala Ile 
    1685                 1690                 1695             


Trp Thr  Ser Ser Ser Phe Gln  Ser Asp Thr Ser Arg  Asp Ile Ser 
    1700                 1705                 1710             


Pro Glu  Lys Ser Glu Leu Asp  Leu Gly Glu Pro Gly  Pro Pro Gly 
    1715                 1720                 1725             


Val Glu  Pro Pro Pro Gln Leu  Leu Asp Ile Gln Cys  Lys Glu Ser 
    1730                 1735                 1740             


Gln Lys  Leu Val Glu Ile His  Leu Arg Glu Ser Val  Asn Gln Asp 
    1745                 1750                 1755             


Lys Glu  Ser Gln Glu Leu Arg  Lys Ser Glu Asp Cys  Arg Glu Ser 
    1760                 1765                 1770             


Glu Ile  Glu Thr Asn Thr Glu  Leu Lys Glu Arg Val  Lys Glu Leu 
    1775                 1780                 1785             


Ser Glu  Gly Ile Val Asp Glu  Gly Val Ser Thr Ser  Ile Gly Pro 
    1790                 1795                 1800             


His Ser  Ile Asp Asp Ser Asn  Leu Asn His Gly Asn  Arg Tyr Met 
    1805                 1810                 1815             


Trp Glu  Gly Glu Val Lys Gln  Pro Asn Leu Leu Met  Ile Asp Lys 
    1820                 1825                 1830             


Glu Ala  Glu Gln Ser Asn Lys  Leu Met Thr Gly Ser  Glu Thr Pro 
    1835                 1840                 1845             


Ser Lys  Val Val Ile Lys Leu  Ser Pro Gln Ala Cys  Ser Phe Thr 
    1850                 1855                 1860             


Lys Ala  Lys Leu Asp Ser Phe  Leu Ser Glu Ala Arg  Ser Leu Leu 
    1865                 1870                 1875             


Asn Pro  Gln Asp Thr Pro Val  Lys Ile Ser Ala Pro  Glu Leu Leu 
    1880                 1885                 1890             


Leu His  Ser Pro Ala Arg Ser  Ala Met Cys Leu Thr  Gly Ser Pro 
    1895                 1900                 1905             


Gln Glu  Gln Gly Val Ser Val  Val Ser Glu Glu Gly  Leu Glu Asn 
    1910                 1915                 1920             


Ser Ala  Pro Glu Ser Ala Ser  Arg Thr Ser Arg Tyr  Arg Ser Leu 
    1925                 1930                 1935             


Lys Leu  Lys Arg Glu Arg Ser  Lys Asp Phe Gln Val  Lys Lys Ile 
    1940                 1945                 1950             


Tyr Glu  Leu Ala Val Trp Asp  Glu Asn Lys Lys Arg  Pro Glu Thr 
    1955                 1960                 1965             


Trp Glu  Ser Pro Glu Lys Pro  Lys Thr Glu Ala Leu  Glu Leu Gln 
    1970                 1975                 1980             


Asp Val  His Pro Glu Leu Thr  Val Thr Ile Glu Ser  Lys Ala Leu 
    1985                 1990                 1995             


Glu Asp  Phe Glu Ala Thr Asp  Leu Lys Val Glu Glu  Leu Thr Ala 
    2000                 2005                 2010             


Leu Gly  Asn Leu Gly Asp Met  Pro Val Asp Phe Cys  Thr Thr Arg 
    2015                 2020                 2025             


Val Ser  Pro Ala His Arg Ser  Pro Thr Val Leu Cys  Gln Lys Val 
    2030                 2035                 2040             


Cys Glu  Glu Asn Ser Val Ser  Pro Ile Gly Cys Asn  Ser Ser Asp 
    2045                 2050                 2055             


Pro Ala  Asp Phe Glu Pro Ile  Pro Ser Phe Ser Gly  Phe Pro Leu 
    2060                 2065                 2070             


Asp Ser  Pro Lys Thr Leu Val  Leu Asp Phe Glu Thr  Glu Gly Glu 
    2075                 2080                 2085             


Arg Asn  Ser Pro Asn Pro Arg  Ser Val Arg Ile Pro  Ser Pro Asn 
    2090                 2095                 2100             


Ile Leu  Lys Thr Gly Leu Thr  Glu Asn Val Asp Arg  Gly Leu Gly 
    2105                 2110                 2115             


Gly Leu  Glu Gly Thr His Gln  Ala Leu Asp Leu Leu  Ala Gly Gly 
    2120                 2125                 2130             


Met Met  Pro Glu Glu Val Lys  Glu Ser Ser Gln Leu  Asp Lys Gln 
    2135                 2140                 2145             


Glu Ser  Leu Gly Leu Glu Leu  Lys Thr Ile Asn Ser  Ala Gly Leu 
    2150                 2155                 2160             


Gly Pro  Ser Pro Cys Leu Pro  Asp Leu Val Asp Phe  Val Thr Arg 
    2165                 2170                 2175             


Thr Ser  Gly Val Gln Lys Asp  Lys Leu Cys Ser Pro  Leu Ser Glu 
    2180                 2185                 2190             


Pro Gly  Asp Pro Ser Lys Cys  Ser Ser Leu Glu Leu  Gly Pro Leu 
    2195                 2200                 2205             


Gln Leu  Glu Ile Ser Asn Ala  Ser Thr Thr Glu Val  Ala Ile Leu 
    2210                 2215                 2220             


Gln Val  Asp Asp Asp Ser Gly  Asp Pro Leu Asn Leu  Val Lys Ala 
    2225                 2230                 2235             


Pro Val  Ser Arg Ser Pro Pro  Arg Glu Gln Val Ile  Glu Asp Asn 
    2240                 2245                 2250             


Met Val  Pro Gln Gly Met Pro  Glu Gln Glu Thr Thr  Val Gly Ala 
    2255                 2260                 2265             


Ile Gln  Asp His Thr Glu Ser  Ser Val His Asn 
    2270                 2275                 


<210> 6047
<211> 643
<212> PRT
<213> Homo sapiens

<400> 6047
Met Gly Gln Glu Ser Ser Lys Pro Val Trp Pro Asn Pro Thr Gly Gly 
1               5                   10                  15      


Tyr Gln Ser Asn Thr Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val 
            20                  25                  30          


Ser Phe Arg Pro Pro Thr Ser Gln Arg Glu Arg Ile Ala Ser Gln Arg 
        35                  40                  45              


Lys Thr Asn Ser Glu Val Pro Met His Arg Ser Ala Pro Ser Gln Thr 
    50                  55                  60                  


Thr Lys Arg Ser Arg Ser Pro Phe Ser Thr Thr Arg Arg Ser Trp Asp 
65                  70                  75                  80  


Asp Ser Glu Ser Ser Gly Thr Asn Leu Asn Ile Asp Asn Glu Asp Tyr 
                85                  90                  95      


Ser Arg Tyr Pro Pro Arg Glu Tyr Arg Ala Ser Gly Ser Arg Arg Gly 
            100                 105                 110         


Met Ala Tyr Gly His Ile Asp Ser Tyr Gly Ala Asp Asp Ser Glu Glu 
        115                 120                 125             


Glu Gly Ala Gly Pro Val Glu Arg Pro Pro Val Arg Gly Lys Thr Gly 
    130                 135                 140                 


Lys Phe Lys Asp Asp Lys Leu Tyr Asp Pro Glu Lys Gly Ala Arg Ser 
145                 150                 155                 160 


Leu Ala Gly Pro Pro Pro His Phe Ser Ser Phe Ser Arg Asp Val Arg 
                165                 170                 175     


Glu Glu Arg Asp Lys Leu Asp Pro Val Pro Ala Ala Arg Cys Ser Ala 
            180                 185                 190         


Ser Arg Ala Asp Phe Leu Pro Gln Ser Ser Val Ala Ser Gln Ser Ser 
        195                 200                 205             


Ser Glu Gly Lys Leu Ala Thr Lys Gly Asp Ser Ser Glu Arg Glu Arg 
    210                 215                 220                 


Arg Glu Gln Asn Leu Pro Ala Arg Pro Ser Arg Ala Pro Val Ser Ile 
225                 230                 235                 240 


Cys Gly Gly Gly Glu Asn Thr Ser Lys Ser Ala Glu Glu Pro Val Val 
                245                 250                 255     


Arg Pro Lys Ile Arg Asn Leu Ala Ser Pro Asn Cys Val Lys Pro Lys 
            260                 265                 270         


Ile Phe Phe Asp Thr Asp Asp Asp Asp Asp Met Pro His Ser Thr Ser 
        275                 280                 285             


Arg Trp Arg Asp Thr Ala Asn Asp Asn Glu Gly His Ser Asp Gly Leu 
    290                 295                 300                 


Ala Arg Arg Gly Arg Gly Glu Ser Ser Ser Gly Tyr Pro Glu Pro Lys 
305                 310                 315                 320 


Tyr Pro Glu Asp Lys Arg Glu Ala Arg Ser Asp Gln Val Lys Pro Glu 
                325                 330                 335     


Lys Val Pro Arg Arg Arg Arg Thr Met Ala Asp Pro Asp Phe Trp Thr 
            340                 345                 350         


His Ser Asp Asp Tyr Tyr Lys Tyr Cys Asp Glu Asp Ser Asp Ser Asp 
        355                 360                 365             


Lys Glu Trp Ile Ala Ala Leu Arg Arg Lys Tyr Arg Ser Arg Glu Gln 
    370                 375                 380                 


Thr Leu Ser Ser Ser Gly Glu Ser Trp Glu Thr Leu Pro Gly Lys Glu 
385                 390                 395                 400 


Glu Arg Glu Pro Pro Gln Ala Lys Val Ser Ala Ser Thr Gly Thr Ser 
                405                 410                 415     


Pro Gly Pro Gly Ala Ser Ala Ser Ala Gly Ala Gly Ala Gly Ala Ser 
            420                 425                 430         


Ala Gly Ser Asn Gly Ser Asn Tyr Leu Glu Glu Val Arg Glu Pro Ser 
        435                 440                 445             


Leu Gln Glu Glu Gln Ala Ser Leu Glu Glu Gly Glu Ile Pro Trp Leu 
    450                 455                 460                 


Gln Tyr His Glu Asn Asp Ser Ser Ser Glu Gly Asp Asn Asp Ser Gly 
465                 470                 475                 480 


His Glu Leu Met Gln Pro Gly Val Phe Met Leu Asp Gly Asn Asn Asn 
                485                 490                 495     


Leu Glu Asp Asp Ser Ser Val Ser Glu Asp Leu Glu Val Asp Trp Ser 
            500                 505                 510         


Leu Phe Asp Gly Phe Ala Asp Gly Leu Gly Val Ala Glu Ala Ile Ser 
        515                 520                 525             


Tyr Val Asp Pro Gln Phe Leu Thr Tyr Met Ala Leu Glu Glu Arg Leu 
    530                 535                 540                 


Ala Gln Ala Met Glu Thr Ala Leu Ala His Leu Glu Ser Leu Ala Val 
545                 550                 555                 560 


Asp Val Glu Val Ala Asn Pro Pro Ala Ser Lys Glu Ser Ile Asp Ala 
                565                 570                 575     


Leu Pro Glu Ile Leu Val Thr Glu Asp His Gly Ala Val Gly Gln Glu 
            580                 585                 590         


Met Cys Cys Pro Ile Cys Cys Ser Glu Tyr Val Lys Gly Glu Val Ala 
        595                 600                 605             


Thr Glu Leu Pro Cys His His Tyr Phe His Lys Pro Cys Val Ser Ile 
    610                 615                 620                 


Trp Leu Gln Lys Ser Gly Thr Cys Pro Val Cys Arg Cys Met Phe Pro 
625                 630                 635                 640 


Pro Pro Leu 
            


<210> 6048
<211> 370
<212> PRT
<213> Homo sapiens

<400> 6048
Met Pro Thr Glu Thr Leu Gln Thr Gly Ser Met Val Lys Pro Val Ser 
1               5                   10                  15      


Pro Ala Gly Thr Phe Thr Ser Ala Val Pro Leu Arg Ile Leu Asn Lys 
            20                  25                  30          


Gly Pro Asp Tyr Phe Arg Arg Gln Ala Glu Pro Asn Pro Lys Arg Leu 
        35                  40                  45              


Ser Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Ser 
    50                  55                  60                  


Gln Glu Val Ile Asn Ala Lys Gln Glu Pro Val Lys Pro Ala Val Leu 
65                  70                  75                  80  


Ala Lys Pro Pro Val Cys Pro Ala Ala Lys Arg Ala Leu Gly Ser Pro 
                85                  90                  95      


Thr Leu Lys Val Phe Gly Asn His Ala Lys Thr Glu Ser Gly Val Gln 
            100                 105                 110         


Arg Glu Asn Leu Lys Leu Glu Ile Leu Lys Asn Ile Ile Asn Ser Ser 
        115                 120                 125             


Glu Gly Ser Ser Ser Gly Ser Gly His Lys His Ser Ser Arg Asn Trp 
    130                 135                 140                 


Pro Pro His Arg Ser Glu Ala Thr Asp Leu His Arg His Ser Phe Ala 
145                 150                 155                 160 


Glu Ser Leu Lys Val Tyr Pro Thr Gln Gly Arg Arg Ser Pro Gln Glu 
                165                 170                 175     


Gly Gly Ser His Val Gly Arg Arg Leu Leu Glu Gln Ser Ala Glu Ser 
            180                 185                 190         


Phe Leu His Val Ser His Ser Ser Ser Asp Ile Arg Lys Val Thr Ser 
        195                 200                 205             


Val Lys Pro Leu Lys Ala Ile Pro Cys Ser Ser Ser Ala Pro Pro Leu 
    210                 215                 220                 


Pro Pro Lys Pro Lys Ile Ala Ala Ile Ala Ser Met Lys Ser Pro Glu 
225                 230                 235                 240 


Ala Asp Pro Val Glu Pro Ala Cys Gly Val Ser Arg Arg Pro Ser Leu 
                245                 250                 255     


Gln Arg Ser Lys Ser Asp Leu Ser Asp Arg Tyr Phe Arg Val Asp Ala 
            260                 265                 270         


Asp Val Glu Arg Phe Phe Asn Tyr Cys Gly Leu Asp Pro Glu Glu Leu 
        275                 280                 285             


Glu Asn Leu Gly Met Glu Asn Phe Ala Arg Ala Asn Ser Asp Ile Ile 
    290                 295                 300                 


Ser Leu Asn Phe Arg Ser Ala Ser Met Ile Ser Ser Asp Cys Glu Gln 
305                 310                 315                 320 


Ser Gln Asp Ser Asn Ser Asp Leu Arg Asn Asp Asp Ser Ala Asn Asp 
                325                 330                 335     


Arg Val Pro Tyr Gly Ile Ser Ala Ile Glu Arg Asn Ala Arg Ile Ile 
            340                 345                 350         


Lys Trp Leu Tyr Ser Ile Lys Gln Ala Arg Glu Ser Gln Lys Val Ser 
        355                 360                 365             


His Val 
    370 


<210> 6049
<211> 1041
<212> PRT
<213> Homo sapiens

<400> 6049
Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210> 6050
<211> 51
<212> PRT
<213> Homo sapiens

<400> 6050
Met Ser Ser His Lys Thr Phe Arg Ile Lys Arg Phe Leu Ala Lys Lys 
1               5                   10                  15      


Gln Lys Gln Asn Arg Pro Ile Pro Gln Trp Ile Arg Met Lys Thr Gly 
            20                  25                  30          


Asn Lys Ile Arg Tyr Asn Ser Lys Arg Arg His Trp Arg Arg Thr Lys 
        35                  40                  45              


Leu Gly Leu 
    50      


<210> 6051
<211> 1208
<212> PRT
<213> Homo sapiens

<400> 6051
Met Asp Ser Leu Pro Asp Glu Phe Phe Val Arg His Pro Ala Val Glu 
1               5                   10                  15      


Asp Gln Arg Lys Glu Glu Thr Glu Asn Lys Leu Glu Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Asn Lys Gln Glu Asn Asp Ile Pro Thr Asp Leu Val Pro Val 
        35                  40                  45              


Asn Leu Leu Leu Glu Val Lys Lys Leu Leu Asn Ala Ile Asn Thr Leu 
    50                  55                  60                  


Pro Lys Gly Val Val Pro His Ile Lys Lys Phe Leu Gln Glu Asp Phe 
65                  70                  75                  80  


Ser Phe Gln Thr Met Gln Arg Glu Val Ala Ala Asn Ser Gln Asn Gly 
                85                  90                  95      


Glu Glu Ile Val Pro Ala Leu Thr Leu Arg Phe Leu Ile Thr Gln Leu 
            100                 105                 110         


Glu Ala Ala Leu Arg Asn Ile Gln Ala Gly Asn Tyr Thr Ala His Gln 
        115                 120                 125             


Ile Asn Ile Gly Tyr Tyr Leu Thr Leu Leu Phe Leu Tyr Gly Val Ala 
    130                 135                 140                 


Leu Thr Glu Arg Gly Lys Lys Glu Asp Tyr Thr Glu Ala Glu Asn Lys 
145                 150                 155                 160 


Phe Leu Val Met Lys Met Met Ile Gln Glu Asn Glu Ile Cys Glu Asn 
                165                 170                 175     


Phe Met Ser Leu Val Tyr Phe Gly Arg Gly Leu Leu Arg Cys Ala Gln 
            180                 185                 190         


Lys Arg Tyr Asn Gly Gly Leu Leu Glu Phe His Lys Ser Leu Gln Glu 
        195                 200                 205             


Ile Gly Asp Lys Asn Asp His Trp Phe Asp Ile Asp Pro Thr Glu Asp 
    210                 215                 220                 


Glu Asp Leu Pro Thr Thr Phe Lys Asp Leu Leu Asn Asn Phe Ile Lys 
225                 230                 235                 240 


Thr Thr Glu Ser Asn Ile Met Lys Gln Thr Ile Cys Ser Tyr Leu Asp 
                245                 250                 255     


Cys Glu Arg Ser Cys Glu Ala Asp Ile Leu Lys Asn Thr Ser Tyr Lys 
            260                 265                 270         


Gly Phe Phe Gln Leu Met Cys Ser Lys Ser Cys Cys Val Tyr Phe His 
        275                 280                 285             


Lys Ile Cys Trp Lys Lys Phe Lys Asn Leu Lys Tyr Pro Gly Glu Asn 
    290                 295                 300                 


Asp Gln Ser Phe Ser Gly Lys Lys Cys Leu Lys Glu Gly Cys Thr Gly 
305                 310                 315                 320 


Asp Met Val Arg Met Leu Gln Cys Asp Val Pro Gly Ile Val Lys Ile 
                325                 330                 335     


Leu Phe Glu Val Val Arg Lys Asp Glu Tyr Ile Thr Ile Glu Asn Leu 
            340                 345                 350         


Gly Ala Ser Tyr Arg Lys Leu Ile Ser Leu Lys Ile Thr Asp Thr Asp 
        355                 360                 365             


Ile Arg Pro Lys Ile Ser Leu Lys Phe Asn Thr Lys Asp Glu Met Pro 
    370                 375                 380                 


Ile Phe Lys Leu Asp Tyr Asn Tyr Phe Tyr His Leu Leu His Ile Ile 
385                 390                 395                 400 


Ile Ile Ser Gly Thr Asp Ile Val Arg Gln Ile Phe Asp Glu Ala Met 
                405                 410                 415     


Pro Pro Pro Leu Leu Lys Lys Glu Leu Leu Ile His Lys Asn Val Leu 
            420                 425                 430         


Glu Ser Tyr Tyr Asn His Leu Trp Thr Asn His Pro Leu Gly Gly Ser 
        435                 440                 445             


Trp His Leu Leu Tyr Pro Pro Asn Lys Glu Leu Pro Gln Ser Lys Gln 
    450                 455                 460                 


Phe Asp Leu Cys Leu Leu Leu Ala Leu Ile Lys His Leu Asn Val Phe 
465                 470                 475                 480 


Pro Ala Pro Lys Lys Gly Trp Asn Met Glu Pro Pro Ser Ser Asp Ile 
                485                 490                 495     


Ser Lys Ser Ala Asp Ile Leu Arg Leu Cys Lys Tyr Arg Asp Ile Leu 
            500                 505                 510         


Leu Ser Glu Ile Leu Met Asn Gly Leu Thr Glu Ser Gln Phe Asn Ser 
        515                 520                 525             


Ile Trp Lys Lys Val Ser Asp Ile Leu Leu Arg Leu Gly Met Met Gln 
    530                 535                 540                 


Glu Asp Ile Asp Lys Val Lys Glu Asn Pro Ile Glu Asn Ile Ser Leu 
545                 550                 555                 560 


Asp Tyr His Gln Leu Ser Val Tyr Leu Gly Ile Pro Val Pro Glu Ile 
                565                 570                 575     


Ile Gln Arg Met Leu Ser Cys Tyr Gln Gln Gly Ile Ala Leu Gln Ser 
            580                 585                 590         


Ile Thr Gly Ser Gln Arg Ile Glu Ile Glu Glu Leu Gln Asn Glu Glu 
        595                 600                 605             


Glu Glu Leu Ser Pro Pro Leu Met Glu Tyr Asn Ile Asn Val Lys Ser 
    610                 615                 620                 


His Pro Glu Ile Gln Phe Ala Glu Ile Asn Lys Asp Gly Thr Ser Ile 
625                 630                 635                 640 


Pro Ser Glu Ser Ser Thr Glu Ser Leu Lys Asp Leu Gln Glu Val Lys 
                645                 650                 655     


Ser Lys Gln Arg Lys Lys Lys Lys Thr Lys Asn Lys Lys Asn Lys Asp 
            660                 665                 670         


Ser Lys Glu Asp Gln Val Pro Tyr Val Val Glu Lys Glu Glu Gln Leu 
        675                 680                 685             


Arg Lys Glu Gln Ala Asn Pro His Ser Val Ser Arg Leu Ile Lys Asp 
    690                 695                 700                 


Asp Ala Ser Asp Val Gln Glu Asp Ser Ala Met Glu Asp Lys Phe Tyr 
705                 710                 715                 720 


Ser Leu Asp Glu Leu His Ile Leu Asp Met Ile Glu Gln Gly Ser Ala 
                725                 730                 735     


Gly Lys Val Thr Thr Asp Tyr Gly Glu Thr Glu Lys Glu Arg Leu Ala 
            740                 745                 750         


Arg Gln Arg Gln Leu Tyr Lys Leu His Tyr Gln Cys Glu Asp Phe Lys 
        755                 760                 765             


Arg Gln Leu Arg Thr Val Thr Phe Arg Trp Gln Glu Asn Gln Met Gln 
    770                 775                 780                 


Ile Lys Lys Lys Asp Lys Ile Ile Ala Ser Leu Asn Gln Gln Val Ala 
785                 790                 795                 800 


Phe Gly Ile Asn Lys Val Ser Lys Leu Gln Arg Gln Ile His Ala Lys 
                805                 810                 815     


Asp Asn Glu Ile Lys Asn Leu Lys Glu Gln Leu Ser Met Lys Arg Ser 
            820                 825                 830         


Gln Trp Glu Met Glu Lys His Asn Leu Glu Ser Thr Met Lys Thr Tyr 
        835                 840                 845             


Val Ser Lys Leu Asn Ala Glu Thr Ser Arg Ala Leu Thr Ala Glu Val 
    850                 855                 860                 


Tyr Phe Leu Gln Cys Arg Arg Asp Phe Gly Leu Leu His Leu Glu Gln 
865                 870                 875                 880 


Thr Glu Lys Glu Cys Leu Asn Gln Leu Ala Arg Val Thr His Met Ala 
                885                 890                 895     


Ala Ser Asn Leu Glu Ser Leu Gln Leu Lys Ala Ala Val Asp Ser Trp 
            900                 905                 910         


Asn Ala Ile Val Ala Asp Val Arg Asn Lys Ile Ala Phe Leu Arg Thr 
        915                 920                 925             


Gln Tyr Asn Glu Gln Ile Asn Lys Val Lys Gln Gly Phe Ala Leu Ser 
    930                 935                 940                 


Thr Leu Pro Pro Val Gln Leu Pro Pro Pro Pro Pro Ser Pro Glu Ile 
945                 950                 955                 960 


Leu Met Gln Gln Phe Leu Gly Arg Pro Leu Val Lys Glu Ser Phe Phe 
                965                 970                 975     


Arg Pro Ile Leu Thr Val Pro Gln Met Pro Ala Val Cys Pro Gly Val 
            980                 985                 990         


Val Ser Ala Thr Gly Gln Pro Arg  Ala Pro Leu Met Thr  Gly Ile Ala 
        995                 1000                 1005             


Trp Ala  Leu Pro Ala Pro Val  Gly Asp Ala Val Pro  Pro Ser Ala 
    1010                 1015                 1020             


Gly Leu  Arg Ser Asp Pro Ser  Ile Met Asn Trp Glu  Arg Ile Thr 
    1025                 1030                 1035             


Asp Arg  Leu Lys Thr Ala Phe  Pro Gln Gln Thr Arg  Lys Glu Leu 
    1040                 1045                 1050             


Thr Asp  Phe Leu Arg Lys Leu  Lys Asp Ala Tyr Gly  Lys Ser Leu 
    1055                 1060                 1065             


Ser Glu  Leu Thr Phe Asp Glu  Ile Val Cys Lys Ile  Ser Gln Phe 
    1070                 1075                 1080             


Ile Asp  Pro Lys Lys Ser Gln  Ser Gln Gly Lys Ser  Val Ser Asn 
    1085                 1090                 1095             


Val Asn  Cys Val Ser Pro Ser  His Ser Pro Ser Gln  Pro Asp Ala 
    1100                 1105                 1110             


Ala Gln  Pro Pro Lys Pro Ala  Trp Arg Pro Leu Thr  Ser Gln Gly 
    1115                 1120                 1125             


Pro Ala  Thr Trp Glu Gly Ala  Ser Asn Pro Asp Glu  Glu Glu Glu 
    1130                 1135                 1140             


Glu Glu  Glu Pro Cys Val Ile  Cys His Glu Asn Leu  Ser Pro Glu 
    1145                 1150                 1155             


Asn Leu  Ser Val Leu Pro Cys  Ala His Lys Phe His  Ala Gln Cys 
    1160                 1165                 1170             


Ile Arg  Pro Trp Leu Met Gln  Gln Gly Thr Cys Pro  Thr Cys Arg 
    1175                 1180                 1185             


Leu His  Val Leu Leu Pro Glu  Glu Phe Pro Gly His  Pro Ser Arg 
    1190                 1195                 1200             


Gln Leu  Pro Lys Ile 
    1205             


<210> 6052
<211> 331
<212> PRT
<213> Homo sapiens

<400> 6052
Met Ser Arg Gln Leu Ser Arg Ala Arg Pro Ala Thr Val Leu Gly Ala 
1               5                   10                  15      


Met Glu Met Gly Arg Arg Met Asp Ala Pro Thr Ser Ala Ala Val Thr 
            20                  25                  30          


Arg Ala Phe Leu Glu Arg Gly His Thr Glu Ile Asp Thr Ala Phe Val 
        35                  40                  45              


Tyr Ser Glu Gly Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Arg 
    50                  55                  60                  


Leu Gly Gly Ser Asp Cys Arg Val Lys Ile Asp Thr Lys Ala Ile Pro 
65                  70                  75                  80  


Leu Phe Gly Asn Ser Leu Lys Pro Asp Ser Leu Arg Phe Gln Leu Glu 
                85                  90                  95      


Thr Ser Leu Lys Arg Leu Gln Cys Pro Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


His Met Pro Asp His Ser Thr Pro Val Glu Glu Thr Leu Arg Ala Cys 
        115                 120                 125             


His Gln Leu His Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn 
    130                 135                 140                 


Tyr Ala Ala Trp Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn 
145                 150                 155                 160 


Gly Trp Ile Leu Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Ile Thr 
                165                 170                 175     


Arg Gln Val Glu Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu 
            180                 185                 190         


Arg Phe Tyr Ala Phe Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Lys 
        195                 200                 205             


Tyr Lys Tyr Glu Asp Lys Asn Gly Lys Gln Pro Val Gly Arg Phe Phe 
    210                 215                 220                 


Gly Asn Thr Trp Ala Glu Met Tyr Arg Asn Arg Tyr Trp Lys Glu His 
225                 230                 235                 240 


His Phe Glu Gly Ile Ala Leu Val Glu Lys Ala Leu Gln Ala Ala Tyr 
                245                 250                 255     


Gly Ala Ser Ala Pro Ser Met Thr Ser Ala Thr Leu Arg Trp Met Tyr 
            260                 265                 270         


His His Ser Gln Leu Gln Gly Ala His Gly Asp Ala Val Ile Leu Gly 
        275                 280                 285             


Met Ser Ser Leu Glu Gln Leu Glu Gln Asn Leu Ala Ala Ala Glu Glu 
    290                 295                 300                 


Gly Pro Leu Glu Pro Ala Val Val Asp Ala Phe Asn Gln Ala Trp His 
305                 310                 315                 320 


Leu Val Thr His Glu Cys Pro Asn Tyr Phe Arg 
                325                 330     


<210> 6053
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6053
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 
            20                  25                  30          


Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Arg Glu Ser Asn Arg 
        355                 360                 365             


Asp Gly Glu Glu Ser Ser Ser Ala 
    370                 375     


<210> 6054
<211> 626
<212> PRT
<213> Homo sapiens

<400> 6054
Met Asp Glu Gln Glu Ala Leu Asn Ser Ile Met Asn Asp Leu Val Ala 
1               5                   10                  15      


Leu Gln Met Asn Arg Arg His Arg Met Pro Gly Tyr Glu Thr Met Lys 
            20                  25                  30          


Asn Lys Asp Thr Gly His Ser Asn Arg Gln Ser Asp Val Arg Ile Lys 
        35                  40                  45              


Phe Glu His Asn Gly Glu Arg Arg Ile Ile Ala Phe Ser Arg Pro Val 
    50                  55                  60                  


Lys Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gln Pro 
65                  70                  75                  80  


Leu Asp Leu His Tyr Met Asn Asn Glu Leu Ser Ile Leu Leu Lys Asn 
                85                  90                  95      


Gln Asp Asp Leu Asp Lys Ala Ile Asp Ile Leu Asp Arg Ser Ser Ser 
            100                 105                 110         


Met Lys Ser Leu Arg Ile Leu Leu Leu Ser Gln Asp Arg Asn His Asn 
        115                 120                 125             


Ser Ser Ser Pro His Ser Gly Val Ser Arg Gln Val Arg Ile Lys Ala 
    130                 135                 140                 


Ser Gln Ser Ala Gly Asp Ile Asn Thr Ile Tyr Gln Pro Pro Glu Pro 
145                 150                 155                 160 


Arg Ser Arg His Leu Ser Val Ser Ser Gln Asn Pro Gly Arg Ser Ser 
                165                 170                 175     


Pro Pro Pro Gly Tyr Val Pro Glu Arg Gln Gln His Ile Ala Arg Gln 
            180                 185                 190         


Gly Ser Tyr Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Thr 
        195                 200                 205             


Ser Glu Gln Cys Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu 
    210                 215                 220                 


Ser Gly Ser Cys Gln Ser Leu Asp Arg Ser Ala Asp Ser Pro Ser Phe 
225                 230                 235                 240 


Arg Lys Ser Arg Met Ser Arg Ala Gln Ser Phe Pro Asp Asn Arg Gln 
                245                 250                 255     


Glu Tyr Ser Asp Arg Glu Thr Gln Leu Tyr Asp Lys Gly Val Lys Gly 
            260                 265                 270         


Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr 
        275                 280                 285             


Ser Asp Gly Arg Arg Thr Phe Pro Arg Ile Arg Arg His Gln Gly Asn 
    290                 295                 300                 


Leu Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr Asn Gly Glu 
305                 310                 315                 320 


Asn Met Gly Leu Ala Val Gln Tyr Leu Asp Pro Arg Gly Arg Leu Arg 
                325                 330                 335     


Ser Ala Asp Ser Glu Asn Ala Leu Ser Val Gln Glu Arg Asn Val Pro 
            340                 345                 350         


Thr Lys Ser Pro Ser Ala Pro Ile Asn Trp Arg Arg Gly Lys Leu Leu 
        355                 360                 365             


Gly Gln Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr 
    370                 375                 380                 


Gly Arg Glu Leu Ala Ser Lys Gln Val Gln Phe Asp Pro Asp Ser Pro 
385                 390                 395                 400 


Glu Thr Ser Lys Glu Val Ser Ala Leu Glu Cys Glu Ile Gln Leu Leu 
                405                 410                 415     


Lys Asn Leu Gln His Glu Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg 
            420                 425                 430         


Asp Arg Ala Glu Lys Thr Leu Thr Ile Phe Met Glu Tyr Met Pro Gly 
        435                 440                 445             


Gly Ser Val Lys Asp Gln Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser 
    450                 455                 460                 


Val Thr Arg Lys Tyr Thr Arg Gln Ile Leu Glu Gly Met Ser Tyr Leu 
465                 470                 475                 480 


His Ser Asn Met Ile Val His Arg Asp Ile Lys Gly Ala Asn Ile Leu 
                485                 490                 495     


Arg Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys 
            500                 505                 510         


Arg Leu Gln Thr Ile Cys Met Ser Gly Thr Gly Met Arg Ser Val Thr 
        515                 520                 525             


Gly Thr Pro Tyr Trp Met Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr 
    530                 535                 540                 


Gly Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr Val Val Glu Met 
545                 550                 555                 560 


Leu Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala Ile 
                565                 570                 575     


Phe Lys Ile Ala Thr Gln Pro Thr Asn Pro Gln Leu Pro Ser His Ile 
            580                 585                 590         


Ser Glu His Gly Arg Asp Phe Leu Arg Arg Ile Phe Val Glu Ala Arg 
        595                 600                 605             


Gln Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe Ala Gln Leu 
    610                 615                 620                 


Met Tyr 
625     


<210> 6055
<211> 566
<212> PRT
<213> Homo sapiens

<400> 6055
Met Asp Leu His Arg Ala Ala Phe Lys Met Glu Asn Ser Ser Tyr Leu 
1               5                   10                  15      


Pro Asn Pro Leu Ala Ser Pro Ala Leu Met Val Leu Ala Ser Thr Ala 
            20                  25                  30          


Glu Ala Ser Arg Asp Ala Ser Ile Pro Cys Gln Gln Pro Arg Pro Phe 
        35                  40                  45              


Gly Val Pro Val Ser Val Asp Lys Asp Val His Ile Pro Phe Thr Asn 
    50                  55                  60                  


Gly Ser Tyr Thr Phe Ala Ser Met Tyr His Arg Gln Gly Gly Val Pro 
65                  70                  75                  80  


Gly Thr Phe Ala Asn Arg Asp Phe Pro Pro Ser Leu Leu His Leu His 
                85                  90                  95      


Pro Gln Phe Ala Pro Pro Asn Leu Asp Cys Thr Pro Ile Ser Met Leu 
            100                 105                 110         


Asn His Ser Gly Val Gly Ala Phe Arg Pro Phe Ala Ser Thr Glu Asp 
        115                 120                 125             


Arg Glu Ser Tyr Gln Ser Ala Phe Thr Pro Ala Lys Arg Leu Lys Asn 
    130                 135                 140                 


Cys His Asp Thr Glu Ser Pro His Leu Arg Phe Ser Asp Ala Asp Gly 
145                 150                 155                 160 


Lys Glu Tyr Asp Phe Gly Thr Gln Leu Pro Ser Ser Ser Pro Gly Ser 
                165                 170                 175     


Leu Lys Val Asp Asp Thr Gly Lys Lys Ile Phe Ala Val Ser Gly Leu 
            180                 185                 190         


Ile Ser Asp Arg Glu Ala Ser Ser Ser Pro Glu Asp Arg Asn Asp Arg 
        195                 200                 205             


Cys Lys Lys Lys Ala Ala Ala Leu Phe Asp Ser Gln Ala Pro Ile Cys 
    210                 215                 220                 


Pro Ile Cys Gln Val Leu Leu Arg Pro Ser Glu Leu Gln Glu His Met 
225                 230                 235                 240 


Glu Gln Glu Leu Glu Gln Leu Ala Gln Leu Pro Ser Ser Lys Asn Ser 
                245                 250                 255     


Leu Leu Lys Asp Ala Met Ala Pro Gly Thr Pro Lys Ser Leu Leu Leu 
            260                 265                 270         


Ser Ala Ser Ile Lys Arg Glu Gly Glu Ser Pro Thr Ala Ser Pro His 
        275                 280                 285             


Ser Ser Ala Thr Asp Asp Leu His His Ser Asp Arg Tyr Gln Thr Phe 
    290                 295                 300                 


Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn Ala Arg Ile Gly 
305                 310                 315                 320 


Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Arg Glu Gly Ser Cys 
                325                 330                 335     


Met Ala Glu Asp Asp Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg 
            340                 345                 350         


Phe Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr 
        355                 360                 365             


Leu Leu Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly 
    370                 375                 380                 


Lys Glu Asn Pro Asp Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp 
385                 390                 395                 400 


Thr Leu Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro 
                405                 410                 415     


Cys Thr Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg 
            420                 425                 430         


Gly Ala Val Leu Asn Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu 
        435                 440                 445             


Phe Ser Lys Trp Ala Ser Asp Glu Met Pro Ser Thr Ser Asn Gly Glu 
    450                 455                 460                 


Ser Ser Lys Gln Glu Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile 
465                 470                 475                 480 


Glu Lys Ile Thr Glu Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys 
                485                 490                 495     


Ala Arg Val Arg Glu Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr 
            500                 505                 510         


Lys Cys Leu Ile Cys Met Asp Ser Tyr Ser Met Pro Leu Thr Ser Ile 
        515                 520                 525             


Gln Cys Trp His Val His Cys Glu Glu Cys Trp Leu Arg Thr Leu Gly 
    530                 535                 540                 


Ala Lys Lys Leu Cys Pro Gln Cys Asn Thr Ile Thr Ala Pro Gly Asp 
545                 550                 555                 560 


Leu Arg Arg Ile Tyr Leu 
                565     


<210> 6056
<211> 151
<212> PRT
<213> Homo sapiens

<400> 6056
Met Glu Gly Cys Val Ser Asn Leu Met Val Cys Asn Leu Ala Tyr Ser 
1               5                   10                  15      


Gly Lys Leu Glu Glu Leu Lys Glu Ser Ile Leu Ala Asp Lys Ser Leu 
            20                  25                  30          


Ala Thr Arg Thr Asp Gln Asp Ser Arg Thr Ala Leu His Trp Ala Cys 
        35                  40                  45              


Ser Ala Gly His Thr Glu Ile Val Glu Phe Leu Leu Gln Leu Gly Val 
    50                  55                  60                  


Pro Val Asn Asp Lys Asp Asp Ala Gly Trp Ser Pro Leu His Ile Ala 
65                  70                  75                  80  


Ala Ser Ala Gly Arg Asp Glu Ile Val Lys Ala Leu Leu Gly Lys Gly 
                85                  90                  95      


Ala Gln Val Asn Ala Val Asn Gln Asn Gly Cys Thr Pro Leu His Tyr 
            100                 105                 110         


Ala Ala Ser Lys Asn Arg His Glu Ile Ala Val Met Leu Leu Glu Gly 
        115                 120                 125             


Gly Ala Asn Pro Asp Ala Lys Asp His Tyr Glu Ala Thr Ala Met His 
    130                 135                 140                 


Arg Ala Ala Ala Lys Asp Thr 
145                 150     


<210> 6057
<211> 739
<212> PRT
<213> Homo sapiens

<400> 6057
Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg 
1               5                   10                  15      


Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe 
            20                  25                  30          


Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys 
        35                  40                  45              


Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln 
    50                  55                  60                  


Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys Glu Val His Gln Thr 
65                  70                  75                  80  


Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln 
                85                  90                  95      


Gln His Val Gln Leu Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn 
            100                 105                 110         


Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu 
        115                 120                 125             


Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn 
    130                 135                 140                 


Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met 
145                 150                 155                 160 


Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro 
                165                 170                 175     


His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys 
            180                 185                 190         


Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu 
        195                 200                 205             


Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile 
    210                 215                 220                 


Leu Phe Thr Lys Ala Glu Asp Asn Leu Leu Ala Leu Gly Leu Lys His 
225                 230                 235                 240 


Phe Glu Gly Thr Glu Phe Leu Asn Pro Leu Ile Ser Lys Tyr Leu Leu 
                245                 250                 255     


Thr Cys Lys Thr Ala Arg Gln Leu Thr Val Arg Ile Lys Asn Leu Asn 
            260                 265                 270         


Met Asn Arg Ala Pro Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr Lys 
        275                 280                 285             


Gln Leu Pro Val Leu Gly Lys Cys Cys Glu Glu Ile Gln Pro His Gln 
    290                 295                 300                 


Trp Lys Pro Pro Ile Glu Arg Glu Glu His Arg Leu Pro Phe Trp Leu 
305                 310                 315                 320 


Lys Ala Ser Leu Pro Ser Ile Gln Glu Glu Leu Arg His Met Ala Asp 
                325                 330                 335     


Gly Ala Arg Glu Val Gly Asn Met Thr Gly Thr Thr Glu Ile Asn Ser 
            340                 345                 350         


Asp Gln Gly Leu Glu Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr Arg 
        355                 360                 365             


Tyr Pro Leu Leu Leu Pro Lys Gly Val Val Leu Lys Leu Lys Pro Val 
    370                 375                 380                 


Ala Asp Arg Phe Pro Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser Val 
385                 390                 395                 400 


Leu Lys Pro Leu Leu Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser Phe 
                405                 410                 415     


Asn Pro Gly Lys Thr Pro Ala Gln Ser Thr His Ser Glu Ala Pro Pro 
            420                 425                 430         


Ser Lys Met Val Leu Arg Ile Pro His Pro Ile Gln Pro Ala Thr Val 
        435                 440                 445             


Leu Gln Thr Val Pro Gly Val Pro Pro Leu Gly Val Ser Gly Gly Glu 
    450                 455                 460                 


Ser Phe Glu Ser Pro Ala Ala Leu Pro Ala Met Pro Pro Glu Ala Arg 
465                 470                 475                 480 


Thr Ser Phe Pro Leu Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala Pro 
                485                 490                 495     


Val Pro Lys Val Met Met Pro Ser Pro Ala Ser Ser Met Phe Arg Lys 
            500                 505                 510         


Pro Tyr Val Arg Arg Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala Phe 
        515                 520                 525             


Arg Cys Ile Lys Pro Ala Pro Val Ile His Pro Ala Ser Val Ile Phe 
    530                 535                 540                 


Thr Val Pro Ala Thr Thr Val Lys Ile Val Ser Leu Gly Gly Gly Cys 
545                 550                 555                 560 


Asn Met Ile Gln Pro Val Asn Ala Ala Val Ala Gln Ser Pro Gln Thr 
                565                 570                 575     


Ile Pro Ile Ala Thr Leu Leu Val Asn Pro Thr Ser Phe Pro Cys Pro 
            580                 585                 590         


Leu Asn Gln Pro Leu Val Ala Ser Ser Val Ser Pro Leu Ile Val Ser 
        595                 600                 605             


Gly Asn Ser Val Asn Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys Ala 
    610                 615                 620                 


His Met Asn Val Asp Ile Ala Cys Ala Val Ala Asp Gly Glu Asn Ala 
625                 630                 635                 640 


Phe Gln Gly Leu Glu Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro Leu 
                645                 650                 655     


Ser Ala Thr Val Phe Pro Lys Val Glu His Ser Pro Gly Pro Pro Pro 
            660                 665                 670         


Val Asp Lys Gln Cys Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr Arg 
        675                 680                 685             


Trp Thr Val Val Lys Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro Leu 
    690                 695                 700                 


Pro Gln Gly Ile Gln Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp Leu 
705                 710                 715                 720 


Glu Glu Val Val Lys Met Glu Pro Glu Asp Ala Thr Glu Glu Ile Ser 
                725                 730                 735     


Gly Phe Leu 
            


<210> 6058
<211> 563
<212> PRT
<213> Homo sapiens

<400> 6058
Met Ser Arg Pro Ser Ser Arg Ala Ile Tyr Leu His Arg Lys Glu Tyr 
1               5                   10                  15      


Ser Gln Asn Leu Thr Ser Glu Pro Thr Leu Leu Gln His Arg Val Glu 
            20                  25                  30          


His Leu Met Thr Cys Lys Gln Gly Ser Gln Arg Val Gln Gly Pro Glu 
        35                  40                  45              


Asp Ala Leu Gln Lys Leu Phe Glu Met Asp Ala Gln Gly Arg Val Trp 
    50                  55                  60                  


Ser Gln Asp Leu Ile Leu Gln Val Arg Asp Gly Trp Leu Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Glu Thr Lys Glu Glu Leu Asp Ser Tyr Arg Leu Asp Ser Ile 
                85                  90                  95      


Gln Ala Met Asn Val Ala Leu Asn Thr Cys Ser Tyr Asn Ser Ile Leu 
            100                 105                 110         


Ser Ile Thr Val Gln Glu Pro Gly Leu Pro Gly Thr Ser Thr Leu Leu 
        115                 120                 125             


Phe Gln Cys Gln Glu Val Gly Ala Glu Arg Leu Lys Thr Ser Leu Gln 
    130                 135                 140                 


Lys Ala Leu Glu Glu Glu Leu Glu Gln Arg Pro Arg Leu Gly Gly Leu 
145                 150                 155                 160 


Gln Pro Gly Gln Asp Arg Trp Arg Gly Pro Ala Met Glu Arg Pro Leu 
                165                 170                 175     


Pro Met Glu Gln Ala Arg Tyr Leu Glu Pro Gly Ile Pro Pro Glu Gln 
            180                 185                 190         


Pro His Gln Arg Thr Leu Glu His Ser Leu Pro Pro Ser Pro Arg Pro 
        195                 200                 205             


Leu Pro Arg His Thr Ser Ala Arg Glu Pro Ser Ala Phe Thr Leu Pro 
    210                 215                 220                 


Pro Pro Arg Arg Ser Ser Ser Pro Glu Asp Pro Glu Arg Asp Glu Glu 
225                 230                 235                 240 


Val Leu Asn His Val Leu Arg Asp Ile Glu Leu Phe Met Gly Lys Leu 
                245                 250                 255     


Glu Lys Ala Gln Ala Lys Thr Ser Arg Lys Lys Lys Phe Gly Lys Lys 
            260                 265                 270         


Asn Lys Asp Gln Gly Gly Leu Thr Gln Ala Gln Tyr Ile Asp Cys Phe 
        275                 280                 285             


Gln Lys Ile Lys His Ser Phe Asn Leu Leu Gly Arg Leu Ala Thr Trp 
    290                 295                 300                 


Leu Lys Glu Thr Ser Ala Pro Glu Leu Val His Ile Leu Phe Lys Ser 
305                 310                 315                 320 


Leu Asn Phe Ile Leu Ala Arg Cys Pro Glu Ala Gly Leu Ala Ala Gln 
                325                 330                 335     


Val Ile Ser Pro Leu Leu Thr Pro Lys Ala Ile Asn Leu Leu Gln Ser 
            340                 345                 350         


Cys Leu Ser Pro Pro Glu Ser Asn Leu Trp Met Gly Leu Gly Pro Ala 
        355                 360                 365             


Trp Thr Thr Ser Arg Ala Asp Trp Thr Gly Asp Glu Pro Leu Pro Tyr 
    370                 375                 380                 


Gln Pro Thr Phe Ser Asp Asp Trp Gln Leu Pro Glu Pro Ser Ser Gln 
385                 390                 395                 400 


Ala Pro Leu Gly Tyr Gln Asp Pro Val Ser Leu Arg Pro Ser Ser Pro 
                405                 410                 415     


Lys Pro Ala Gln Pro Ala Leu Lys Met Gln Val Leu Tyr Glu Phe Glu 
            420                 425                 430         


Ala Arg Asn Pro Arg Glu Leu Thr Val Val Gln Gly Glu Lys Leu Glu 
        435                 440                 445             


Val Leu Asp His Ser Lys Arg Trp Trp Leu Val Lys Asn Glu Ala Gly 
    450                 455                 460                 


Arg Ser Gly Tyr Ile Pro Ser Asn Ile Leu Glu Pro Leu Gln Pro Gly 
465                 470                 475                 480 


Thr Pro Gly Thr Gln Gly Gln Ser Pro Ser Arg Val Pro Met Leu Arg 
                485                 490                 495     


Leu Ser Ser Arg Pro Glu Glu Val Thr Asp Trp Leu Gln Ala Glu Asn 
            500                 505                 510         


Phe Ser Thr Ala Thr Val Arg Thr Leu Gly Ser Leu Thr Gly Ser Gln 
        515                 520                 525             


Leu Leu Arg Ile Arg Pro Gly Glu Leu Gln Met Leu Cys Pro Gln Glu 
    530                 535                 540                 


Ala Pro Arg Ile Leu Ser Arg Leu Glu Ala Val Arg Arg Met Leu Gly 
545                 550                 555                 560 


Ile Ser Pro 
            


<210> 6059
<211> 174
<212> PRT
<213> Homo sapiens

<400> 6059
Met Thr Cys Cys Gln Thr Ser Phe Cys Gly Tyr Pro Ser Phe Ser Ile 
1               5                   10                  15      


Ser Gly Thr Cys Gly Ser Ser Cys Cys Gln Pro Ser Cys Cys Glu Thr 
            20                  25                  30          


Ser Cys Cys Gln Pro Arg Ser Cys Gln Thr Ser Phe Cys Gly Phe Pro 
        35                  40                  45              


Ser Phe Ser Thr Ser Gly Thr Cys Ser Ser Ser Cys Cys Gln Pro Ser 
    50                  55                  60                  


Cys Cys Glu Thr Ser Cys Cys Gln Pro Ser Cys Cys Glu Thr Ser Cys 
65                  70                  75                  80  


Cys Gln Pro Ser Cys Cys Gln Ile Ser Ser Cys Gly Thr Gly Cys Gly 
                85                  90                  95      


Ile Gly Gly Gly Ile Ser Tyr Gly Gln Glu Gly Ser Ser Gly Ala Val 
            100                 105                 110         


Ser Thr Arg Ile Arg Trp Cys Arg Pro Asp Ser Arg Val Glu Gly Thr 
        115                 120                 125             


Tyr Leu Pro Pro Cys Cys Val Val Ser Cys Thr Pro Pro Ser Cys Cys 
    130                 135                 140                 


Gln Leu His His Ala Gln Ala Ser Cys Cys Arg Pro Ser Tyr Cys Gly 
145                 150                 155                 160 


Gln Ser Cys Cys Arg Pro Val Cys Cys Cys Glu Pro Thr Cys 
                165                 170                 


<210> 6060
<211> 390
<212> PRT
<213> Homo sapiens

<400> 6060
Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg 
1               5                   10                  15      


Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe 
            20                  25                  30          


Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro 
        35                  40                  45              


Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu 
    50                  55                  60                  


Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys 
65                  70                  75                  80  


Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu 
                85                  90                  95      


Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr 
            100                 105                 110         


Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile 
        115                 120                 125             


Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu 
    130                 135                 140                 


Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn 
145                 150                 155                 160 


Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu 
                165                 170                 175     


Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His 
            180                 185                 190         


Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala 
        195                 200                 205             


Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile 
    210                 215                 220                 


Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu 
225                 230                 235                 240 


Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn 
                245                 250                 255     


Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu 
            260                 265                 270         


Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr 
        275                 280                 285             


Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu 
    290                 295                 300                 


Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile 
305                 310                 315                 320 


Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala 
                325                 330                 335     


Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr 
            340                 345                 350         


Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu 
        355                 360                 365             


Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu 
    370                 375                 380                 


Ser Met Glu Thr Gln Glu 
385                 390 


<210> 6061
<211> 1201
<212> PRT
<213> Homo sapiens

<400> 6061
Met Pro Arg Gly Glu Ala Pro Gly Pro Gly Arg Arg Gly Ala Lys Asp 
1               5                   10                  15      


Glu Ala Leu Gly Glu Glu Ser Gly Glu Arg Trp Ser Pro Glu Phe His 
            20                  25                  30          


Leu Gln Arg Lys Leu Ala Asp Ser Ser His Ser Glu Gln Gln Asp Arg 
        35                  40                  45              


Asn Arg Val Ser Glu Glu Leu Ile Met Val Val Gln Glu Met Lys Lys 
    50                  55                  60                  


Tyr Phe Pro Ser Glu Arg Arg Asn Lys Pro Ser Thr Leu Asp Ala Leu 
65                  70                  75                  80  


Asn Tyr Ala Leu Arg Cys Val His Ser Val Gln Ala Asn Ser Glu Phe 
                85                  90                  95      


Phe Gln Ile Leu Ser Gln Asn Gly Ala Pro Gln Ala Asp Val Ser Met 
            100                 105                 110         


Tyr Ser Leu Glu Glu Leu Ala Thr Ile Ala Ser Glu His Thr Ser Lys 
        115                 120                 125             


Asn Thr Asp Thr Phe Val Ala Val Phe Ser Phe Leu Ser Gly Arg Leu 
    130                 135                 140                 


Val His Ile Ser Glu Gln Ala Ala Leu Ile Leu Asn Arg Lys Lys Asp 
145                 150                 155                 160 


Val Leu Ala Ser Ser His Phe Val Asp Leu Leu Ala Pro Gln Asp Met 
                165                 170                 175     


Arg Val Phe Tyr Ala His Thr Ala Arg Ala Gln Leu Pro Phe Trp Asn 
            180                 185                 190         


Asn Trp Thr Gln Arg Ala Ala Arg Tyr Glu Cys Ala Pro Val Lys Pro 
        195                 200                 205             


Phe Phe Cys Arg Ile Arg Gly Gly Glu Asp Arg Lys Gln Glu Lys Cys 
    210                 215                 220                 


His Ser Pro Phe Arg Ile Ile Pro Tyr Leu Ile His Val His His Pro 
225                 230                 235                 240 


Ala Gln Pro Glu Leu Glu Ser Glu Pro Cys Cys Leu Thr Val Val Glu 
                245                 250                 255     


Lys Ile His Ser Gly Tyr Glu Ala Pro Arg Ile Pro Val Asn Lys Arg 
            260                 265                 270         


Ile Phe Thr Thr Thr His Thr Pro Gly Cys Val Phe Leu Glu Val Asp 
        275                 280                 285             


Glu Lys Ala Val Pro Leu Leu Gly Tyr Leu Pro Gln Asp Leu Ile Gly 
    290                 295                 300                 


Thr Ser Ile Leu Ser Tyr Leu His Pro Glu Asp Arg Ser Leu Met Val 
305                 310                 315                 320 


Ala Ile His Gln Lys Val Leu Lys Tyr Ala Gly His Pro Pro Phe Glu 
                325                 330                 335     


His Ser Pro Ile Arg Phe Cys Thr Gln Asn Gly Asp Tyr Ile Ile Leu 
            340                 345                 350         


Asp Ser Ser Trp Ser Ser Phe Val Asn Pro Trp Ser Arg Lys Ile Ser 
        355                 360                 365             


Phe Ile Ile Gly Arg His Lys Val Arg Thr Ser Pro Leu Asn Glu Asp 
    370                 375                 380                 


Val Phe Ala Thr Lys Ile Lys Lys Met Asn Asp Asn Asp Lys Asp Ile 
385                 390                 395                 400 


Thr Glu Leu Gln Glu Gln Ile Tyr Lys Leu Leu Leu Gln Pro Val His 
                405                 410                 415     


Val Ser Val Ser Ser Gly Tyr Gly Ser Leu Gly Ser Ser Gly Ser Gln 
            420                 425                 430         


Glu Gln Leu Val Ser Ile Ala Ser Ser Ser Glu Ala Ser Gly His Arg 
        435                 440                 445             


Val Glu Glu Thr Lys Ala Glu Gln Met Thr Leu Gln Gln Val Tyr Ala 
    450                 455                 460                 


Ser Val Asn Lys Ile Lys Asn Leu Gly Gln Gln Leu Tyr Ile Glu Ser 
465                 470                 475                 480 


Met Thr Lys Ser Ser Phe Lys Pro Val Thr Gly Thr Arg Thr Glu Pro 
                485                 490                 495     


Asn Gly Gly Gly Glu Cys Lys Thr Phe Thr Ser Phe His Gln Thr Leu 
            500                 505                 510         


Lys Asn Asn Ser Val Tyr Thr Glu Pro Cys Glu Asp Leu Arg Asn Asp 
        515                 520                 525             


Glu His Ser Pro Ser Tyr Gln Gln Ile Asn Cys Ile Asp Ser Val Ile 
    530                 535                 540                 


Arg Tyr Leu Lys Ser Tyr Asn Ile Pro Ala Leu Lys Arg Lys Cys Ile 
545                 550                 555                 560 


Ser Cys Thr Asn Thr Thr Ser Ser Ser Ser Glu Glu Asp Lys Gln Asn 
                565                 570                 575     


His Lys Ala Asp Asp Val Gln Ala Leu Gln Ala Gly Leu Gln Ile Pro 
            580                 585                 590         


Ala Ile Pro Lys Ser Glu Met Pro Thr Asn Gly Arg Ser Ile Asp Thr 
        595                 600                 605             


Gly Gly Gly Ala Pro Gln Ile Leu Ser Thr Ala Met Leu Ser Leu Gly 
    610                 615                 620                 


Ser Gly Ile Ser Gln Cys Gly Tyr Ser Ser Thr Ile Val His Val Pro 
625                 630                 635                 640 


Pro Pro Glu Thr Ala Arg Asp Ala Thr Leu Phe Cys Glu Pro Trp Thr 
                645                 650                 655     


Leu Asn Met Gln Pro Ala Pro Leu Thr Ser Glu Glu Phe Lys His Val 
            660                 665                 670         


Gly Leu Thr Ala Ala Val Leu Ser Ala His Thr Gln Lys Glu Glu Gln 
        675                 680                 685             


Asn Tyr Val Asp Lys Phe Arg Glu Lys Ile Leu Ser Ser Pro Tyr Ser 
    690                 695                 700                 


Ser Tyr Leu Gln Gln Glu Ser Arg Ser Lys Ala Lys Tyr Ser Tyr Phe 
705                 710                 715                 720 


Gln Gly Asp Ser Thr Ser Lys Gln Thr Arg Ser Ala Gly Cys Arg Lys 
                725                 730                 735     


Gly Lys His Lys Arg Lys Lys Leu Pro Glu Pro Pro Asp Ser Ser Ser 
            740                 745                 750         


Ser Asn Thr Gly Ser Gly Pro Arg Arg Gly Ala His Gln Asn Ala Gln 
        755                 760                 765             


Pro Cys Cys Pro Ser Ala Ala Ser Ser Pro His Thr Ser Ser Pro Thr 
    770                 775                 780                 


Phe Pro Pro Ala Ala Met Val Pro Ser Gln Ala Pro Tyr Leu Val Pro 
785                 790                 795                 800 


Ala Phe Pro Leu Pro Ala Ala Thr Ser Pro Gly Arg Glu Tyr Ala Ala 
                805                 810                 815     


Pro Gly Thr Ala Pro Glu Gly Leu His Gly Leu Pro Leu Ser Glu Gly 
            820                 825                 830         


Leu Gln Pro Tyr Pro Ala Phe Pro Phe Pro Tyr Leu Asp Thr Phe Met 
        835                 840                 845             


Thr Val Phe Leu Pro Asp Pro Pro Val Cys Pro Leu Leu Ser Pro Ser 
    850                 855                 860                 


Phe Leu Pro Cys Pro Phe Leu Gly Ala Thr Ala Ser Ser Ala Ile Ser 
865                 870                 875                 880 


Pro Ser Met Ser Ser Ala Met Ser Pro Thr Leu Asp Pro Pro Pro Ser 
                885                 890                 895     


Val Thr Ser Gln Arg Arg Glu Glu Glu Lys Trp Glu Ala Gln Ser Glu 
            900                 905                 910         


Gly His Pro Phe Ile Thr Ser Arg Ser Ser Ser Pro Leu Gln Leu Asn 
        915                 920                 925             


Leu Leu Gln Glu Glu Met Pro Arg Pro Ser Glu Ser Pro Asp Gln Met 
    930                 935                 940                 


Arg Arg Asn Thr Cys Pro Gln Thr Glu Tyr Cys Val Thr Gly Asn Asn 
945                 950                 955                 960 


Gly Ser Glu Ser Ser Pro Ala Thr Thr Gly Ala Leu Ser Thr Gly Ser 
                965                 970                 975     


Pro Pro Arg Glu Asn Pro Ser His Pro Thr Ala Ser Ala Leu Ser Thr 
            980                 985                 990         


Gly Ser Pro Pro Met Lys Asn Pro  Ser His Pro Thr Ala  Ser Ala Leu 
        995                 1000                 1005             


Ser Thr  Gly Ser Pro Pro Met  Lys Asn Pro Ser His  Pro Thr Ala 
    1010                 1015                 1020             


Ser Thr  Leu Ser Met Gly Leu  Pro Pro Ser Arg Thr  Pro Ser His 
    1025                 1030                 1035             


Pro Thr  Ala Thr Val Leu Ser  Thr Gly Ser Pro Pro  Ser Glu Ser 
    1040                 1045                 1050             


Pro Ser  Arg Thr Gly Ser Ala  Ala Ser Gly Ser Ser  Asp Ser Ser 
    1055                 1060                 1065             


Ile Tyr  Leu Thr Ser Ser Val  Tyr Ser Ser Lys Ile  Ser Gln Asn 
    1070                 1075                 1080             


Gly Gln  Gln Ser Gln Asp Val  Gln Lys Lys Glu Thr  Phe Pro Asn 
    1085                 1090                 1095             


Val Ala  Glu Glu Pro Ile Trp  Arg Met Ile Arg Gln  Thr Pro Glu 
    1100                 1105                 1110             


Arg Ile  Leu Met Thr Tyr Gln  Val Pro Glu Arg Val  Lys Glu Val 
    1115                 1120                 1125             


Val Leu  Lys Glu Asp Leu Glu  Lys Leu Glu Ser Met  Arg Gln Gln 
    1130                 1135                 1140             


Gln Pro  Gln Phe Ser His Gly  Gln Lys Glu Glu Leu  Ala Lys Val 
    1145                 1150                 1155             


Tyr Asn  Trp Ile Gln Ser Gln  Thr Val Thr Gln Glu  Ile Asp Ile 
    1160                 1165                 1170             


Gln Ala  Cys Val Thr Cys Glu  Asn Glu Asp Ser Ala  Asp Gly Ala 
    1175                 1180                 1185             


Ala Thr  Ser Cys Gly Gln Val  Leu Val Glu Asp Ser  Cys 
    1190                 1195                 1200     


<210> 6062
<211> 431
<212> PRT
<213> Homo sapiens

<400> 6062
Met Ser Asp Gln Ile Lys Phe Ile Met Asp Ser Leu Asn Lys Glu Pro 
1               5                   10                  15      


Phe Arg Lys Asn Tyr Asn Leu Ile Thr Phe Asp Ser Leu Glu Pro Met 
            20                  25                  30          


Gln Leu Leu Gln Val Leu Ser Asp Val Leu Ala Glu Ile Asp Pro Lys 
        35                  40                  45              


Gln Leu Val Asp Ile Arg Glu Glu Met Pro Glu Gln Thr Ala Lys Arg 
    50                  55                  60                  


Met Leu Ser Leu Leu Gly Ile Leu Lys Tyr Lys Pro Ser Gly Asn Ala 
65                  70                  75                  80  


Thr Asp Met Ser Thr Phe Arg Gln Gly Leu Val Ile Gly Ser Lys Pro 
                85                  90                  95      


Val Ile Tyr Pro Val Leu His Trp Leu Leu Gln Arg Thr Asn Glu Leu 
            100                 105                 110         


Lys Lys Arg Ala Tyr Leu Ala Arg Phe Leu Ile Lys Leu Glu Val Pro 
        115                 120                 125             


Ser Glu Phe Leu Gln Asp Glu Thr Val Ala Asp Thr Asn Lys Gln Tyr 
    130                 135                 140                 


Glu Glu Leu Met Glu Ala Phe Lys Thr Leu His Lys Glu Tyr Glu Gln 
145                 150                 155                 160 


Leu Lys Ile Ser Gly Phe Ser Thr Ala Glu Ile Arg Lys Asp Ile Ser 
                165                 170                 175     


Ala Met Glu Glu Glu Lys Asp Gln Leu Ile Lys Arg Val Glu His Leu 
            180                 185                 190         


Lys Lys Arg Val Glu Thr Ala Gln Asn His Gln Trp Met Leu Lys Ile 
        195                 200                 205             


Ala Arg Gln Leu Arg Val Glu Lys Glu Arg Glu Glu Tyr Leu Ala Gln 
    210                 215                 220                 


Gln Lys Gln Glu Gln Lys Asn Gln Leu Phe His Ala Val Gln Arg Leu 
225                 230                 235                 240 


Gln Arg Val Gln Asn Gln Leu Lys Ser Met Arg Gln Ala Ala Ala Asp 
                245                 250                 255     


Ala Lys Pro Glu Ser Leu Met Lys Arg Leu Glu Glu Glu Ile Lys Phe 
            260                 265                 270         


Asn Leu Tyr Met Val Thr Glu Lys Phe Pro Lys Glu Leu Glu Asn Lys 
        275                 280                 285             


Lys Lys Glu Leu His Phe Leu Gln Lys Val Val Ser Glu Pro Ala Met 
    290                 295                 300                 


Gly His Ser Asp Leu Leu Glu Leu Glu Ser Lys Ile Asn Glu Ile Asn 
305                 310                 315                 320 


Thr Glu Ile Asn Gln Leu Ile Glu Lys Lys Met Met Arg Asn Glu Pro 
                325                 330                 335     


Ile Glu Gly Lys Leu Ser Leu Tyr Arg Gln Gln Ala Ser Ile Ile Ser 
            340                 345                 350         


Arg Lys Lys Glu Ala Lys Ala Glu Glu Leu Gln Glu Ala Lys Glu Lys 
        355                 360                 365             


Leu Ala Ser Leu Glu Arg Glu Ala Ser Val Lys Arg Asn Gln Thr Arg 
    370                 375                 380                 


Glu Phe Asp Gly Thr Glu Val Leu Lys Gly Asp Glu Arg Gln Asp Leu 
385                 390                 395                 400 


Thr Leu Ser Pro Arg Leu Glu Cys Gly Gly Val Ile Met Ala Tyr Cys 
                405                 410                 415     


Ser Leu Lys Leu Leu Gly Ser Ser Asp Pro Pro Thr Ser Ala Ser 
            420                 425                 430     


<210> 6063
<211> 372
<212> PRT
<213> Homo sapiens

<400> 6063
Met Ala Ser Ser Ala Ser Ala Arg Thr Pro Ala Gly Lys Arg Val Ile 
1               5                   10                  15      


Asn Gln Glu Glu Leu Arg Arg Leu Met Lys Glu Lys Gln Arg Leu Ser 
            20                  25                  30          


Thr Ser Arg Lys Arg Ile Glu Ser Pro Phe Ala Lys Tyr Asn Arg Leu 
        35                  40                  45              


Gly Gln Leu Ser Cys Ala Leu Cys Asn Thr Pro Val Lys Ser Glu Leu 
    50                  55                  60                  


Leu Trp Gln Thr His Val Leu Gly Lys Gln His Arg Glu Lys Val Ala 
65                  70                  75                  80  


Glu Leu Lys Gly Ala Lys Glu Ala Ser Gln Gly Ser Ser Ala Ser Ser 
                85                  90                  95      


Ala Pro His Ser Val Lys Arg Lys Ala Pro Asp Ala Asp Asp Gln Asp 
            100                 105                 110         


Val Lys Arg Ala Lys Ala Thr Leu Val Pro Gln Val Gln Pro Ser Thr 
        115                 120                 125             


Ser Ala Trp Thr Thr Asn Phe Asp Lys Ile Gly Lys Glu Phe Ile Arg 
    130                 135                 140                 


Ala Thr Pro Ser Lys Pro Ser Gly Leu Ser Leu Leu Pro Asp Tyr Glu 
145                 150                 155                 160 


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Asp Gly Glu Arg Lys 
                165                 170                 175     


Arg Gly Asp Ala Ser Lys Pro Leu Ser Asp Ala Gln Gly Lys Glu His 
            180                 185                 190         


Ser Val Ser Ser Ser Arg Glu Val Thr Ser Ser Val Leu Pro Asn Asp 
        195                 200                 205             


Phe Phe Ser Thr Asn Pro Pro Lys Ala Pro Ile Ile Pro His Ser Gly 
    210                 215                 220                 


Ser Ile Glu Lys Ala Glu Ile His Glu Lys Val Val Glu Arg Arg Glu 
225                 230                 235                 240 


Asn Thr Ala Glu Ala Leu Pro Glu Gly Phe Phe Asp Asp Pro Glu Val 
                245                 250                 255     


Asp Ala Arg Val Arg Lys Val Asp Ala Pro Lys Asp Gln Met Asp Lys 
            260                 265                 270         


Glu Trp Asp Glu Phe Gln Lys Ala Met Arg Gln Val Asn Thr Ile Ser 
        275                 280                 285             


Glu Ala Ile Val Ala Glu Glu Asp Glu Glu Gly Arg Leu Asp Arg Gln 
    290                 295                 300                 


Ile Gly Glu Ile Asp Glu Gln Ile Glu Cys Tyr Arg Arg Val Glu Lys 
305                 310                 315                 320 


Leu Arg Asn Arg Gln Asp Glu Ile Lys Asn Lys Leu Lys Glu Ile Leu 
                325                 330                 335     


Thr Ile Lys Glu Leu Gln Lys Lys Glu Glu Glu Asn Ala Asp Ser Asp 
            340                 345                 350         


Asp Glu Gly Glu Leu Gln Asp Leu Leu Ser Gln Asp Trp Arg Val Lys 
        355                 360                 365             


Gly Ala Leu Leu 
    370         


<210> 6064
<211> 593
<212> PRT
<213> Homo sapiens

<400> 6064
Met Ser Arg Pro Ser Ser Arg Ala Ile Tyr Leu His Arg Lys Glu Tyr 
1               5                   10                  15      


Ser Gln Asn Leu Thr Ser Glu Pro Thr Leu Leu Gln His Arg Val Glu 
            20                  25                  30          


His Leu Met Thr Cys Lys Gln Gly Ser Gln Arg Val Gln Gly Pro Glu 
        35                  40                  45              


Asp Ala Leu Gln Lys Leu Phe Glu Met Asp Ala Gln Gly Arg Val Trp 
    50                  55                  60                  


Ser Gln Asp Leu Ile Leu Gln Val Arg Asp Gly Trp Leu Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Glu Thr Lys Glu Glu Leu Asp Ser Tyr Arg Leu Asp Ser Ile 
                85                  90                  95      


Gln Ala Met Asn Val Ala Leu Asn Thr Cys Ser Tyr Asn Ser Ile Leu 
            100                 105                 110         


Ser Ile Thr Val Gln Glu Pro Gly Leu Pro Gly Thr Ser Thr Leu Leu 
        115                 120                 125             


Phe Gln Cys Gln Glu Val Gly Ala Glu Arg Leu Lys Thr Ser Leu Gln 
    130                 135                 140                 


Lys Ala Leu Glu Glu Glu Leu Glu Gln Arg Pro Arg Leu Gly Gly Leu 
145                 150                 155                 160 


Gln Pro Gly Gln Asp Arg Trp Arg Gly Pro Ala Met Glu Arg Pro Leu 
                165                 170                 175     


Pro Met Glu Gln Ala Arg Tyr Leu Glu Pro Gly Ile Pro Pro Glu Gln 
            180                 185                 190         


Pro His Gln Arg Thr Leu Glu His Ser Leu Pro Pro Ser Pro Arg Pro 
        195                 200                 205             


Leu Pro Arg His Thr Ser Ala Arg Glu Pro Ser Ala Phe Thr Leu Pro 
    210                 215                 220                 


Pro Pro Arg Arg Ser Ser Ser Pro Glu Asp Pro Glu Arg Asp Glu Glu 
225                 230                 235                 240 


Val Leu Asn His Val Leu Arg Asp Ile Glu Leu Phe Met Gly Lys Leu 
                245                 250                 255     


Glu Lys Ala Gln Ala Lys Thr Ser Arg Lys Lys Lys Phe Gly Lys Lys 
            260                 265                 270         


Asn Lys Asp Gln Gly Gly Leu Thr Gln Ala Gln Tyr Ile Asp Cys Phe 
        275                 280                 285             


Gln Lys Ile Lys His Ser Phe Asn Leu Leu Gly Arg Leu Ala Thr Trp 
    290                 295                 300                 


Leu Lys Glu Thr Ser Ala Pro Glu Leu Val His Ile Leu Phe Lys Ser 
305                 310                 315                 320 


Leu Asn Phe Ile Leu Ala Arg Cys Pro Glu Ala Gly Leu Ala Ala Gln 
                325                 330                 335     


Val Ile Ser Pro Leu Leu Thr Pro Lys Ala Ile Asn Leu Leu Gln Ser 
            340                 345                 350         


Cys Leu Ser Pro Pro Glu Ser Asn Leu Trp Met Gly Leu Gly Pro Ala 
        355                 360                 365             


Trp Thr Thr Ser Arg Ala Asp Trp Thr Gly Asp Glu Pro Leu Pro Tyr 
    370                 375                 380                 


Gln Pro Thr Phe Ser Asp Asp Trp Gln Leu Pro Glu Pro Ser Ser Gln 
385                 390                 395                 400 


Ala Pro Leu Gly Tyr Gln Asp Pro Val Ser Leu Arg Arg Gly Ser His 
                405                 410                 415     


Arg Leu Gly Ser Thr Ser His Phe Pro Gln Glu Lys Thr His Asn His 
            420                 425                 430         


Asp Pro Gln Pro Gly Asp Pro Asn Ser Arg Pro Ser Ser Pro Lys Pro 
        435                 440                 445             


Ala Gln Pro Ala Leu Lys Met Gln Val Leu Tyr Glu Phe Glu Ala Arg 
    450                 455                 460                 


Asn Pro Arg Glu Leu Thr Val Val Gln Gly Glu Lys Leu Glu Val Leu 
465                 470                 475                 480 


Asp His Ser Lys Arg Trp Trp Leu Val Lys Asn Glu Ala Gly Arg Ser 
                485                 490                 495     


Gly Tyr Ile Pro Ser Asn Ile Leu Glu Pro Leu Gln Pro Gly Thr Pro 
            500                 505                 510         


Gly Thr Gln Gly Gln Ser Pro Ser Arg Val Pro Met Leu Arg Leu Ser 
        515                 520                 525             


Ser Arg Pro Glu Glu Val Thr Asp Trp Leu Gln Ala Glu Asn Phe Ser 
    530                 535                 540                 


Thr Ala Thr Val Arg Thr Leu Gly Ser Leu Thr Gly Ser Gln Leu Leu 
545                 550                 555                 560 


Arg Ile Arg Pro Gly Glu Leu Gln Met Leu Cys Pro Gln Glu Ala Pro 
                565                 570                 575     


Arg Ile Leu Ser Arg Leu Glu Ala Val Arg Arg Met Leu Gly Ile Ser 
            580                 585                 590         


Pro 
    


<210> 6065
<211> 349
<212> PRT
<213> Homo sapiens

<400> 6065
Met Lys Leu Thr Ser Glu Lys Leu Pro Lys Asn Pro Phe Tyr Ala Ser 
1               5                   10                  15      


Val Ser Gln Tyr Ala Ala Lys Asn Gln Lys Phe Phe Gln Trp Lys Lys 
            20                  25                  30          


Glu Lys Thr Glu Ser Asp Tyr Thr His Ala Asn Leu Val Asp Lys Ala 
        35                  40                  45              


Leu Gln Leu Leu Lys Glu Arg Ile Leu Lys Gly Asp Thr Leu Ala Tyr 
    50                  55                  60                  


Phe Leu Arg Gly Gln Leu Tyr Phe Glu Glu Gly Trp Tyr Glu Glu Ala 
65                  70                  75                  80  


Leu Glu Gln Phe Glu Glu Ile Lys Glu Lys Asp His Gln Ala Thr Tyr 
                85                  90                  95      


Gln Leu Gly Val Met Tyr Tyr Asp Gly Leu Gly Thr Thr Leu Asp Ala 
            100                 105                 110         


Glu Lys Gly Val Asp Tyr Met Lys Lys Ile Leu Asp Ser Pro Cys Pro 
        115                 120                 125             


Lys Ala Arg His Leu Lys Phe Ala Ala Ala Tyr Asn Leu Gly Arg Ala 
    130                 135                 140                 


Tyr Tyr Glu Gly Lys Gly Val Lys Arg Ser Asn Glu Glu Ala Glu Arg 
145                 150                 155                 160 


Leu Trp Leu Ile Ala Ala Asp Asn Gly Asn Pro Lys Ala Ser Val Lys 
                165                 170                 175     


Ala Gln Ser Met Leu Gly Leu Tyr Tyr Ser Thr Lys Glu Pro Lys Glu 
            180                 185                 190         


Leu Glu Lys Ala Phe Tyr Trp His Ser Glu Ala Cys Gly Asn Gly Asn 
        195                 200                 205             


Leu Glu Ser Gln Gly Ala Leu Gly Leu Met Tyr Leu Tyr Gly Gln Gly 
    210                 215                 220                 


Ile Arg Gln Asp Thr Glu Ala Ala Leu Gln Cys Leu Arg Glu Ala Ala 
225                 230                 235                 240 


Glu Arg Gly Asn Val Tyr Ala Gln Gly Asn Leu Val Glu Tyr Tyr Tyr 
                245                 250                 255     


Lys Met Lys Phe Phe Thr Lys Cys Val Ala Phe Ser Lys Arg Ile Ala 
            260                 265                 270         


Asp Tyr Asp Glu Val His Asp Ile Pro Met Ile Ala Gln Val Thr Asp 
        275                 280                 285             


Cys Leu Pro Glu Phe Ile Gly Arg Gly Met Ala Met Ala Ser Phe Tyr 
    290                 295                 300                 


His Ala Arg Cys Leu Gln Leu Gly Leu Gly Ile Thr Arg Asp Glu Thr 
305                 310                 315                 320 


Thr Ala Lys His Tyr Tyr Ser Lys Ala Cys Arg Leu Asn Pro Ala Leu 
                325                 330                 335     


Ala Asp Glu Leu His Ser Leu Leu Ile Arg Gln Arg Ile 
            340                 345                 


<210> 6066
<211> 411
<212> PRT
<213> Homo sapiens

<400> 6066
Met Gly Leu Lys Lys Met Lys Gly Leu Ser Tyr Asp Glu Ala Phe Ala 
1               5                   10                  15      


Met Ala Asn Asp Pro Leu Glu Gly Phe His Glu Val Asn Leu Ala Ser 
            20                  25                  30          


Pro Thr Ser Pro Asp Leu Leu Gly Val Tyr Glu Ser Gly Thr Gln Glu 
        35                  40                  45              


Gln Thr Thr Ser Pro Ser Val Ile Tyr Arg Pro His Pro Ser Ala Leu 
    50                  55                  60                  


Ser Ser Val Pro Ile Gln Ala Asn Ala Leu Asp Val Ser Glu Leu Pro 
65                  70                  75                  80  


Thr Gln Pro Val Tyr Ser Ser Pro Arg Arg Leu Asn Cys Ala Glu Ile 
                85                  90                  95      


Ser Ser Ile Ser Phe His Val Thr Asp Pro Ala Pro Cys Ser Thr Ser 
            100                 105                 110         


Gly Val Thr Ala Gly Leu Thr Lys Leu Thr Thr Arg Lys Asp Asn Tyr 
        115                 120                 125             


Asn Ala Glu Arg Glu Phe Leu Gln Gly Ala Thr Ile Thr Glu Ala Cys 
    130                 135                 140                 


Asp Gly Ser Asp Asp Ile Phe Gly Leu Ser Thr Asp Ser Leu Ser Arg 
145                 150                 155                 160 


Leu Arg Ser Pro Ser Val Leu Glu Val Arg Glu Lys Gly Tyr Glu Arg 
                165                 170                 175     


Leu Lys Glu Glu Leu Ala Lys Ala Gln Arg Glu Leu Lys Leu Lys Asp 
            180                 185                 190         


Glu Glu Cys Glu Arg Leu Ser Lys Val Arg Asp Gln Leu Gly Gln Glu 
        195                 200                 205             


Leu Glu Glu Leu Thr Ala Ser Leu Phe Glu Glu Ala His Lys Met Val 
    210                 215                 220                 


Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu Lys Glu 
225                 230                 235                 240 


Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala Leu Lys 
                245                 250                 255     


Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu Pro Leu 
            260                 265                 270         


Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn Lys Ser 
        275                 280                 285             


Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val Ile Gln 
    290                 295                 300                 


Pro Ile Val Lys Asp Cys Lys Glu Ala Asp Leu Ser Leu Tyr Asn Glu 
305                 310                 315                 320 


Phe Arg Leu Trp Lys Asp Glu Pro Thr Met Asp Arg Thr Cys Pro Phe 
                325                 330                 335     


Leu Asp Lys Ile Tyr Gln Glu Asp Ile Phe Pro Cys Leu Thr Phe Ser 
            340                 345                 350         


Lys Ser Glu Leu Ala Ser Ala Val Leu Glu Ala Val Glu Asn Asn Thr 
        355                 360                 365             


Leu Ser Ile Glu Pro Val Gly Leu Gln Pro Ile Arg Phe Val Lys Ala 
    370                 375                 380                 


Ser Ala Val Glu Cys Gly Gly Pro Lys Ser Leu Leu Tyr Val Thr Phe 
385                 390                 395                 400 


Leu His Thr Phe Asp Thr Phe Ser Arg Asp Ser 
                405                 410     


<210> 6067
<211> 715
<212> PRT
<213> Homo sapiens

<400> 6067
Met Phe Gly Arg Lys Arg Ser Val Ser Phe Gly Gly Phe Gly Trp Ile 
1               5                   10                  15      


Asp Lys Thr Met Leu Ala Ser Leu Lys Val Lys Lys Gln Glu Leu Ala 
            20                  25                  30          


Asn Ser Ser Asp Ala Thr Leu Pro Asp Arg Pro Leu Ser Pro Pro Leu 
        35                  40                  45              


Thr Ala Pro Pro Thr Met Lys Ser Ser Glu Phe Phe Glu Met Leu Glu 
    50                  55                  60                  


Lys Met Gln Asp Asp Tyr Ile Pro Tyr Pro Ser Ile Asp Glu Val Val 
65                  70                  75                  80  


Glu Lys Gly Gly Pro Tyr Pro Gln Val Ile Leu Pro Gln Phe Gly Gly 
                85                  90                  95      


Tyr Trp Ile Glu Asp Pro Glu Asn Val Gly Thr Pro Thr Ser Leu Gly 
            100                 105                 110         


Ser Ser Ile Cys Glu Glu Glu Glu Glu Asp Asn Leu Ser Pro Asn Thr 
        115                 120                 125             


Phe Gly Tyr Lys Leu Glu Cys Lys Gly Glu Ala Arg Ala Tyr Arg Arg 
    130                 135                 140                 


His Phe Leu Gly Lys Asp His Leu Asn Phe Tyr Cys Thr Gly Ser Ser 
145                 150                 155                 160 


Leu Gly Asn Leu Ile Leu Ser Val Lys Cys Glu Glu Ala Glu Gly Ile 
                165                 170                 175     


Glu Tyr Leu Arg Val Ile Leu Arg Ser Lys Leu Lys Thr Val His Glu 
            180                 185                 190         


Arg Ile Pro Leu Ala Gly Leu Ser Lys Leu Pro Ser Val Pro Gln Ile 
        195                 200                 205             


Ala Lys Ala Phe Cys Asp Asp Ala Val Gly Leu Arg Phe Asn Pro Val 
    210                 215                 220                 


Leu Tyr Pro Lys Ala Ser Gln Met Ile Val Ser Tyr Asp Glu His Glu 
225                 230                 235                 240 


Val Asn Asn Thr Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala Arg Gln 
                245                 250                 255     


Thr Leu Glu Glu Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro Ala Phe 
            260                 265                 270         


Lys Glu Phe Leu Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln Asp Phe 
        275                 280                 285             


Lys Gly Phe Arg Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Val 
    290                 295                 300                 


Glu Ser Val Tyr Thr Thr Phe Arg Asp Arg Glu Ile Met Phe His Val 
305                 310                 315                 320 


Ser Thr Lys Leu Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu Gln Arg 
                325                 330                 335     


Lys Arg His Ile Gly Asn Asp Ile Val Ala Ile Ile Phe Gln Glu Glu 
            340                 345                 350         


Asn Thr Pro Phe Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala 
        355                 360                 365             


Tyr Ile Val Val Gln Val Glu Thr Pro Gly Thr Glu Thr Pro Ser Tyr 
    370                 375                 380                 


Lys Val Ser Val Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro Pro 
385                 390                 395                 400 


Leu Pro Ser Pro Pro Val Phe Gln Lys Gly Pro Glu Phe Arg Glu Phe 
                405                 410                 415     


Leu Leu Thr Lys Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser Asp 
            420                 425                 430         


Lys Phe Ala Lys Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp Asn 
        435                 440                 445             


Leu His Asp Glu Leu His Ala His Thr Gln Ala Met Leu Gly Leu Gly 
    450                 455                 460                 


Pro Glu Glu Asp Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu Glu 
465                 470                 475                 480 


Ser Phe Lys Arg Ala Ile Arg Val Arg Ser His Ser Met Glu Thr Met 
                485                 490                 495     


Val Gly Gly Gln Lys Lys Ser His Ser Gly Gly Ile Pro Gly Ser Leu 
            500                 505                 510         


Ser Gly Gly Ile Ser His Asn Ser Met Glu Val Thr Lys Thr Thr Phe 
        515                 520                 525             


Ser Pro Pro Val Val Ala Ala Thr Val Lys Asn Gln Ser Arg Ser Pro 
    530                 535                 540                 


Ile Lys Arg Arg Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser Glu 
545                 550                 555                 560 


Gly Gln Gly Asp Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr Pro 
                565                 570                 575     


Lys Thr Pro Asp Gly Gly His Ser Ser Gln Glu Ile Lys Ser Glu Thr 
            580                 585                 590         


Ser Ser Asn Pro Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu Lys Pro 
        595                 600                 605             


Phe Met Lys Leu Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser Ser Ser 
    610                 615                 620                 


Ser Thr Ser Ser Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met Glu 
625                 630                 635                 640 


Glu Gly Asp Ser Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro Phe Lys 
                645                 650                 655     


Gln Glu Val Phe Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro Ser 
            660                 665                 670         


Leu Gly Ala Ala Ala Thr Pro Ile Ile Met Ser Arg Ser Pro Thr Asp 
        675                 680                 685             


Ala Lys Ser Arg Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe Asp 
    690                 695                 700                 


Lys Leu Ser His Ala Ser Ser Gly Ala Gly His 
705                 710                 715 


<210> 6068
<211> 756
<212> PRT
<213> Homo sapiens

<400> 6068
Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe Arg Glu 
1               5                   10                  15      


Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys Ala Arg 
            20                  25                  30          


Thr Ile Ala Val Gln Thr Pro Asp Gly Glu Gln His Leu Pro Gln Pro 
        35                  40                  45              


Leu Leu Leu Ser Arg Gly Ser Gly Leu Gln Ala Gly Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ser Leu Glu His Asp Ala Ala Ala Gly Pro Ala Cys Gly Gly Ala 
65                  70                  75                  80  


Gly Gly Ser Ala Ala Gly Gly Leu Gly Gly Gly Ala Gly Gly Gly Gly 
                85                  90                  95      


Asp His Ala Asp Lys Leu Ser Leu Tyr Ser Glu Thr Asp Ser Gly Tyr 
            100                 105                 110         


Gly Ser Tyr Thr Pro Ser Leu Lys Ser Pro Asn Gly Val Arg Val Leu 
        115                 120                 125             


Pro Met Val Pro Ala Pro Pro Gly Ser Ser Ala Ala Ala Ala Arg Gly 
    130                 135                 140                 


Ala Ala Cys Ser Ser Leu Ser Ser Ser Ser Ser Ser Ile Thr Cys Pro 
145                 150                 155                 160 


Gln Cys His Arg Ser Ala Ser Leu Asp His Arg Gly Leu Arg Gly Phe 
                165                 170                 175     


Gln Arg Asn Arg Leu Leu Glu Ala Ile Val Gln Arg Tyr Gln Gln Gly 
            180                 185                 190         


Arg Gly Ala Val Pro Gly Thr Ser Ala Ala Ala Ala Val Ala Ile Cys 
        195                 200                 205             


Gln Leu Cys Asp Arg Thr Pro Pro Glu Pro Ala Ala Thr Leu Cys Glu 
    210                 215                 220                 


Gln Cys Asp Val Leu Tyr Cys Ser Ala Cys Gln Leu Lys Cys His Pro 
225                 230                 235                 240 


Ser Arg Gly Pro Phe Ala Lys His Arg Leu Val Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Pro Ala Glu Ala Ala Ser Gly Pro Thr Gly Thr Ala Gln 
            260                 265                 270         


Gly Ala Pro Ser Gly Gly Gly Gly Cys Lys Ser Pro Gly Gly Ala Gly 
        275                 280                 285             


Ala Gly Ala Thr Gly Gly Ser Thr Ala Arg Lys Phe Pro Thr Cys Pro 
    290                 295                 300                 


Glu His Glu Met Glu Asn Tyr Ser Met Tyr Cys Val Ser Cys Arg Thr 
305                 310                 315                 320 


Pro Val Cys Tyr Leu Cys Leu Glu Glu Gly Arg His Ala Lys His Glu 
                325                 330                 335     


Val Lys Pro Leu Gly Ala Met Trp Lys Gln His Lys Ala Gln Leu Ser 
            340                 345                 350         


Gln Ala Leu Asn Gly Val Ser Asp Lys Ala Lys Glu Ala Lys Glu Phe 
        355                 360                 365             


Leu Val Gln Leu Lys Asn Ile Leu Gln Gln Ile Gln Glu Asn Gly Leu 
    370                 375                 380                 


Asp Tyr Glu Ala Cys Leu Val Ala Gln Cys Asp Ala Leu Val Asp Ala 
385                 390                 395                 400 


Leu Thr Arg Gln Lys Ala Lys Leu Leu Thr Lys Val Thr Lys Glu Arg 
                405                 410                 415     


Glu His Lys Leu Lys Met Val Trp Asp Gln Ile Asn His Cys Thr Leu 
            420                 425                 430         


Lys Leu Arg Gln Ser Thr Gly Leu Met Glu Tyr Cys Leu Glu Val Ile 
        435                 440                 445             


Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln Ile Ser Asp Ala Leu Ile 
    450                 455                 460                 


Lys Arg Val Gln Val Ser Gln Glu Gln Trp Val Lys Gly Ala Leu Glu 
465                 470                 475                 480 


Pro Lys Val Ser Ala Glu Phe Asp Leu Thr Leu Asp Ser Glu Pro Leu 
                485                 490                 495     


Leu Gln Ala Ile His Gln Leu Asp Phe Ile Gln Met Lys Cys Arg Val 
            500                 505                 510         


Pro Pro Val Pro Leu Leu Gln Leu Glu Lys Cys Cys Thr Arg Asn Asn 
        515                 520                 525             


Ser Val Thr Leu Ala Trp Arg Met Pro Pro Phe Thr His Ser Pro Val 
    530                 535                 540                 


Asp Gly Tyr Ile Leu Glu Leu Asp Asp Gly Ala Gly Gly Gln Phe Arg 
545                 550                 555                 560 


Glu Val Tyr Val Gly Lys Glu Thr Leu Cys Thr Ile Asp Gly Leu His 
                565                 570                 575     


Phe Asn Ser Thr Tyr Asn Ala Arg Val Lys Ala Phe Asn Ser Ser Gly 
            580                 585                 590         


Val Gly Pro Tyr Ser Lys Thr Val Val Leu Gln Thr Ser Asp Val Ala 
        595                 600                 605             


Trp Phe Thr Phe Asp Pro Asn Ser Gly His Arg Asp Ile Ile Leu Ser 
    610                 615                 620                 


Asn Asp Asn Gln Thr Ala Thr Cys Ser Ser Tyr Asp Asp Arg Val Val 
625                 630                 635                 640 


Leu Gly Thr Ala Ala Phe Ser Lys Gly Val His Tyr Trp Glu Leu His 
                645                 650                 655     


Val Asp Arg Tyr Asp Asn His Pro Asp Pro Ala Phe Gly Val Ala Arg 
            660                 665                 670         


Ala Ser Val Val Lys Asp Met Met Leu Gly Lys Asp Asp Lys Ala Trp 
        675                 680                 685             


Ala Met Tyr Val Asp Asn Asn Arg Ser Trp Phe Met His Cys Asn Ser 
    690                 695                 700                 


His Thr Asn Arg Thr Glu Gly Gly Val Cys Lys Gly Ala Thr Val Gly 
705                 710                 715                 720 


Val Leu Leu Asp Leu Asn Lys His Thr Leu Thr Phe Phe Ile Asn Gly 
                725                 730                 735     


Gln Gln Gln Gly Pro Thr Ala Phe Ser His Glu Val Gln Pro Ser Val 
            740                 745                 750         


Thr Ser Leu Phe 
        755     


<210> 6069
<211> 783
<212> PRT
<213> Homo sapiens

<400> 6069
Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe Arg Glu 
1               5                   10                  15      


Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys Ala Arg 
            20                  25                  30          


Thr Ile Ala Val Gln Thr Pro Asp Gly Glu Gln His Leu Pro Gln Pro 
        35                  40                  45              


Leu Leu Leu Ser Arg Gly Ser Gly Leu Gln Ala Gly Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ser Leu Glu His Asp Ala Ala Ala Gly Pro Ala Cys Gly Gly Ala 
65                  70                  75                  80  


Gly Gly Ser Ala Ala Gly Gly Leu Gly Gly Gly Ala Gly Gly Gly Gly 
                85                  90                  95      


Asp His Ala Asp Lys Leu Ser Leu Tyr Ser Glu Thr Asp Ser Gly Tyr 
            100                 105                 110         


Gly Ser Tyr Thr Pro Ser Leu Lys Ser Pro Asn Gly Val Arg Val Leu 
        115                 120                 125             


Pro Met Val Pro Ala Pro Pro Gly Ser Ser Ala Ala Ala Ala Arg Gly 
    130                 135                 140                 


Ala Ala Cys Ser Ser Leu Ser Ser Ser Ser Ser Ser Ile Thr Cys Pro 
145                 150                 155                 160 


Gln Cys His Arg Ser Ala Ser Leu Asp His Arg Gly Leu Arg Gly Phe 
                165                 170                 175     


Gln Arg Asn Arg Leu Leu Glu Ala Ile Val Gln Arg Tyr Gln Gln Gly 
            180                 185                 190         


Arg Gly Ala Val Pro Gly Thr Ser Ala Ala Ala Ala Val Ala Ile Cys 
        195                 200                 205             


Gln Leu Cys Asp Arg Thr Pro Pro Glu Pro Ala Ala Thr Leu Cys Glu 
    210                 215                 220                 


Gln Cys Asp Val Leu Tyr Cys Ser Ala Cys Gln Leu Lys Cys His Pro 
225                 230                 235                 240 


Ser Arg Gly Pro Phe Ala Lys His Arg Leu Val Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Pro Ala Glu Ala Ala Ser Gly Pro Thr Gly Thr Ala Gln 
            260                 265                 270         


Gly Ala Pro Ser Gly Gly Gly Gly Cys Lys Ser Pro Gly Gly Ala Gly 
        275                 280                 285             


Ala Gly Ala Thr Gly Gly Ser Thr Ala Arg Lys Phe Pro Thr Cys Pro 
    290                 295                 300                 


Glu His Glu Met Glu Asn Tyr Ser Met Tyr Cys Val Ser Cys Arg Thr 
305                 310                 315                 320 


Pro Val Cys Tyr Leu Cys Leu Glu Glu Gly Arg His Ala Lys His Glu 
                325                 330                 335     


Val Lys Pro Leu Gly Ala Met Trp Lys Gln His Lys Ala Gln Leu Ser 
            340                 345                 350         


Gln Ala Leu Asn Gly Val Ser Asp Lys Ala Lys Glu Ala Lys Glu Phe 
        355                 360                 365             


Leu Val Gln Leu Lys Asn Ile Leu Gln Gln Ile Gln Glu Asn Gly Leu 
    370                 375                 380                 


Asp Tyr Glu Ala Cys Leu Val Ala Gln Cys Asp Ala Leu Val Asp Ala 
385                 390                 395                 400 


Leu Thr Arg Gln Lys Ala Lys Leu Leu Thr Lys Val Thr Lys Glu Arg 
                405                 410                 415     


Glu His Lys Leu Lys Met Val Trp Asp Gln Ile Asn His Cys Thr Leu 
            420                 425                 430         


Lys Leu Arg Gln Ser Thr Gly Leu Met Glu Tyr Cys Leu Glu Val Ile 
        435                 440                 445             


Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln Ile Ser Asp Ala Leu Ile 
    450                 455                 460                 


Lys Arg Val Gln Val Ser Gln Glu Gln Trp Val Lys Gly Ala Leu Glu 
465                 470                 475                 480 


Pro Lys Val Ser Ala Glu Phe Asp Leu Thr Leu Asp Ser Glu Pro Leu 
                485                 490                 495     


Leu Gln Ala Ile His Gln Leu Asp Phe Ile Gln Met Lys Cys Arg Val 
            500                 505                 510         


Pro Pro Val Pro Leu Leu Gln Leu Glu Lys Cys Cys Thr Arg Asn Asn 
        515                 520                 525             


Ser Val Thr Leu Ala Trp Arg Met Pro Pro Phe Thr His Ser Pro Val 
    530                 535                 540                 


Asp Gly Tyr Ile Leu Glu Leu Asp Asp Gly Ala Gly Gly Gln Phe Arg 
545                 550                 555                 560 


Glu Val Tyr Val Gly Lys Glu Thr Leu Cys Thr Ile Asp Gly Leu His 
                565                 570                 575     


Phe Asn Ser Thr Tyr Asn Ala Arg Val Lys Ala Phe Asn Ser Ser Gly 
            580                 585                 590         


Val Gly Pro Tyr Ser Lys Thr Val Val Leu Gln Thr Ser Asp Val Ala 
        595                 600                 605             


Trp Phe Thr Phe Asp Pro Asn Ser Gly His Arg Asp Ile Ile Leu Ser 
    610                 615                 620                 


Asn Asp Asn Gln Thr Ala Thr Cys Ser Ser Tyr Asp Asp Arg Val Val 
625                 630                 635                 640 


Leu Gly Thr Ala Ala Phe Ser Lys Gly Val His Tyr Trp Glu Leu His 
                645                 650                 655     


Val Asp Arg Tyr Asp Asn His Pro Asp Pro Ala Phe Gly Val Ala Arg 
            660                 665                 670         


Ala Ser Val Val Lys Asp Met Met Leu Gly Lys Asp Asp Lys Ala Trp 
        675                 680                 685             


Ala Met Tyr Val Asp Asn Asn Arg Ser Trp Phe Met His Cys Asn Ser 
    690                 695                 700                 


His Thr Asn Arg Thr Glu Gly Gly Val Cys Lys Gly Ala Thr Val Gly 
705                 710                 715                 720 


Val Leu Leu Asp Leu Asn Lys His Thr Leu Thr Phe Phe Ile Asn Gly 
                725                 730                 735     


Gln Gln Gln Gly Pro Thr Ala Phe Ser His Val Asp Gly Val Phe Met 
            740                 745                 750         


Pro Ala Leu Ser Leu Asn Arg Asn Val Gln Val Thr Leu His Thr Gly 
        755                 760                 765             


Leu Glu Val Pro Thr Asn Leu Gly Arg Pro Lys Leu Ser Gly Asn 
    770                 775                 780             


<210> 6070
<211> 156
<212> PRT
<213> Homo sapiens

<400> 6070
Met Val Pro Val Phe Thr Ser Ser Ala Leu Pro Val Lys Asp Val Glu 
1               5                   10                  15      


Asp Lys Pro Glu Gln Gln Thr Arg Thr Arg Glu Thr Asp Lys Ser Pro 
            20                  25                  30          


Thr Ser Thr Glu Pro Arg Gln Gln Pro Ser Ala Leu Phe Ala Arg Gly 
        35                  40                  45              


Asn Arg Lys Ala Val Lys Ser Pro Gln Arg Ser Ser Ser Lys Ile Lys 
    50                  55                  60                  


Glu Asn Lys His Pro Phe Ala Leu Tyr Gly Trp Gly Glu Lys Gln Thr 
65                  70                  75                  80  


Asp Thr Gly Ser Gln Lys Thr His Asn Val Cys Ala Ser Ala Pro Val 
                85                  90                  95      


His Glu Ile His Glu Ser Ala Leu Arg Ala Lys Asn Arg Arg Gln Val 
            100                 105                 110         


Glu Lys Arg Lys Leu Val Ala Gln Arg Gln Arg Ala His Ser Val Asp 
        115                 120                 125             


Val Glu Lys Asn Arg Lys Met Lys Ala Ser Ser Ser Glu Asn Pro Trp 
    130                 135                 140                 


Met Thr Glu Tyr Met Arg Cys Tyr Ser Ala Arg Ala 
145                 150                 155     


<210> 6071
<211> 270
<212> PRT
<213> Homo sapiens

<400> 6071
Met Ser Pro Gly Ser Gly Val Lys Ser Glu Tyr Met Lys Arg Tyr Gln 
1               5                   10                  15      


Glu Pro Arg Trp Glu Glu Tyr Gly Pro Cys Tyr Arg Glu Leu Leu His 
            20                  25                  30          


Tyr Arg Leu Gly Arg Arg Leu Leu Glu Gln Ala His Ala Pro Trp Leu 
        35                  40                  45              


Trp Asp Asp Trp Gly Pro Ala Gly Ser Ser Glu Asp Ser Ala Ser Ser 
    50                  55                  60                  


Glu Ser Ser Gly Ala Gly Gly Pro Ala Pro Arg Cys Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Pro Pro Pro Val Glu Pro Ala Thr Gln Glu Glu Ala Glu Arg Arg 
                85                  90                  95      


Ala Arg Gly Ala Pro Glu Glu Gln Asp Ala Glu Ala Gly Asp Ala Glu 
            100                 105                 110         


Ala Glu Asp Ala Glu Asp Ala Ala Leu Pro Ala Leu Pro Val Lys Asp 
        115                 120                 125             


Val Glu Asp Lys Pro Glu Gln Gln Thr Arg Thr Arg Glu Thr Asp Lys 
    130                 135                 140                 


Ser Pro Thr Ser Thr Glu Pro Arg Gln Gln Pro Ser Ala Leu Phe Ala 
145                 150                 155                 160 


Arg Gly Asn Arg Lys Ala Val Lys Ser Pro Gln Arg Ser Ser Ser Lys 
                165                 170                 175     


Ile Lys Glu Asn Lys His Pro Phe Ala Leu Tyr Gly Trp Gly Glu Lys 
            180                 185                 190         


Gln Thr Asp Thr Gly Ser Gln Lys Thr His Asn Val Cys Ala Ser Ala 
        195                 200                 205             


Pro Val His Glu Ile His Glu Ser Ala Leu Arg Ala Lys Asn Arg Arg 
    210                 215                 220                 


Gln Val Glu Lys Arg Lys Leu Val Ala Gln Arg Gln Arg Ala His Ser 
225                 230                 235                 240 


Val Asp Val Glu Lys Asn Arg Lys Met Lys Ala Ser Ser Ser Glu Asn 
                245                 250                 255     


Pro Trp Met Thr Glu Tyr Met Arg Cys Tyr Ser Ala Arg Ala 
            260                 265                 270 


<210> 6072
<211> 385
<212> PRT
<213> Homo sapiens

<400> 6072
Met Ala Ala Pro Asp Leu Ser Thr Asn Leu Gln Glu Glu Ala Thr Cys 
1               5                   10                  15      


Ala Ile Cys Leu Asp Tyr Phe Thr Asp Pro Val Met Thr Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Glu Cys Ile Arg Arg Cys Trp Gly Gln Pro Glu 
        35                  40                  45              


Gly Pro Tyr Ala Cys Pro Glu Cys Arg Glu Leu Ser Pro Gln Arg Asn 
    50                  55                  60                  


Leu Arg Pro Asn Arg Pro Leu Ala Lys Met Ala Glu Met Ala Arg Arg 
65                  70                  75                  80  


Leu His Pro Pro Ser Pro Val Pro Gln Gly Val Cys Pro Ala His Arg 
                85                  90                  95      


Glu Pro Leu Ala Ala Phe Cys Gly Asp Glu Leu Arg Leu Leu Cys Ala 
            100                 105                 110         


Ala Cys Glu Arg Ser Gly Glu His Trp Ala His Arg Val Arg Pro Leu 
        115                 120                 125             


Gln Asp Ala Ala Glu Asp Leu Lys Ala Lys Leu Glu Lys Ser Leu Glu 
    130                 135                 140                 


His Leu Arg Lys Gln Met Gln Asp Ala Leu Leu Phe Gln Ala Gln Ala 
145                 150                 155                 160 


Asp Glu Thr Cys Val Leu Trp Gln Lys Met Val Glu Ser Gln Arg Gln 
                165                 170                 175     


Asn Val Leu Gly Glu Phe Glu Arg Leu Arg Arg Leu Leu Ala Glu Glu 
            180                 185                 190         


Glu Gln Gln Leu Leu Gln Arg Leu Glu Glu Glu Glu Leu Glu Val Leu 
        195                 200                 205             


Pro Arg Leu Arg Glu Gly Ala Ala His Leu Gly Gln Gln Ser Ala His 
    210                 215                 220                 


Leu Ala Glu Leu Ile Ala Glu Leu Glu Gly Arg Cys Gln Leu Pro Ala 
225                 230                 235                 240 


Leu Gly Leu Leu Gln Asp Ile Lys Asp Ala Leu Arg Arg Val Gln Asp 
                245                 250                 255     


Val Lys Leu Gln Pro Pro Glu Val Val Pro Met Glu Leu Arg Thr Val 
            260                 265                 270         


Cys Arg Val Pro Gly Leu Val Glu Thr Leu Arg Arg Phe Arg Gly Arg 
        275                 280                 285             


Cys Gly Gly Pro Arg Trp Gly Asp Asp Ser Arg Arg Gly Pro Ala Lys 
    290                 295                 300                 


Asp Leu Gly Ser Gln Pro Arg Val Leu Cys Pro Ala Thr Ala Ser Ser 
305                 310                 315                 320 


Lys Leu Thr Val Ser Trp Trp Trp Val Val Gly Lys Thr Ser Ser Ala 
                325                 330                 335     


His Thr Ser Asp Ile Ser Cys Val Gly Ile Phe Thr Pro Asn Asn Ser 
            340                 345                 350         


Ser Thr Ser Gly Asn Glu Leu Gly Ile Gln Gly Phe His Ser Ala Leu 
        355                 360                 365             


Asn Arg Ile Ala Ser Ala Asp Thr Thr Gly Val Ser Thr Asp Pro Thr 
    370                 375                 380                 


Asp 
385 


<210> 6073
<211> 416
<212> PRT
<213> Homo sapiens

<400> 6073
Met Pro Leu Tyr Asn Asp Ser Phe His Glu Ile Ser His Lys Gly Arg 
1               5                   10                  15      


Arg His Thr Leu Val Leu Lys Ser Ile Gln Arg Ala Asp Ala Gly Ile 
            20                  25                  30          


Val Arg Ala Ser Ser Leu Lys Val Ser Thr Ser Ala Arg Leu Glu Val 
        35                  40                  45              


Arg Val Lys Pro Val Val Phe Leu Lys Ala Leu Asp Asp Leu Ser Ala 
    50                  55                  60                  


Glu Glu Arg Gly Thr Leu Ala Leu Gln Cys Glu Val Ser Asp Pro Glu 
65                  70                  75                  80  


Ala His Val Val Trp Arg Lys Asp Gly Val Gln Leu Gly Pro Ser Asp 
                85                  90                  95      


Lys Tyr Asp Phe Leu His Thr Ala Gly Thr Arg Gly Leu Val Val His 
            100                 105                 110         


Asp Val Ser Pro Glu Asp Ala Gly Leu Tyr Thr Cys His Val Gly Ser 
        115                 120                 125             


Glu Glu Thr Arg Ala Arg Val Arg Val His Asp Leu His Val Gly Ile 
    130                 135                 140                 


Thr Lys Arg Leu Lys Thr Met Glu Val Leu Glu Gly Glu Ser Cys Ser 
145                 150                 155                 160 


Phe Glu Cys Val Leu Ser His Glu Ser Ala Ser Asp Pro Ala Met Trp 
                165                 170                 175     


Thr Val Gly Gly Lys Thr Val Gly Ser Ser Ser Arg Phe Gln Ala Thr 
            180                 185                 190         


Arg Gln Gly Arg Lys Tyr Ile Leu Val Val Arg Glu Ala Ala Pro Ser 
        195                 200                 205             


Asp Ala Gly Glu Val Val Phe Ser Val Arg Gly Leu Thr Ser Lys Ala 
    210                 215                 220                 


Ser Leu Ile Val Arg Glu Arg Pro Ala Ala Ile Ile Lys Pro Leu Glu 
225                 230                 235                 240 


Asp Gln Trp Val Ala Pro Gly Glu Asp Val Glu Leu Arg Cys Glu Leu 
                245                 250                 255     


Ser Arg Ala Gly Thr Pro Val His Trp Leu Lys Asp Arg Lys Ala Ile 
            260                 265                 270         


Arg Lys Ser Gln Lys Tyr Asp Val Val Cys Glu Gly Thr Met Ala Met 
        275                 280                 285             


Leu Val Ile Arg Gly Ala Ser Leu Lys Asp Ala Gly Glu Tyr Thr Cys 
    290                 295                 300                 


Glu Val Glu Ala Ser Lys Ser Thr Ala Ser Leu His Val Glu Glu Lys 
305                 310                 315                 320 


Ala Asn Cys Phe Thr Glu Glu Leu Thr Asn Leu Gln Val Glu Glu Lys 
                325                 330                 335     


Gly Thr Ala Val Phe Thr Cys Lys Thr Glu His Pro Ala Ala Thr Val 
            340                 345                 350         


Thr Trp Arg Lys Gly Leu Leu Glu Leu Arg Ala Ser Gly Lys His Gln 
        355                 360                 365             


Pro Ser Gln Glu Gly Leu Thr Leu Arg Leu Thr Ile Ser Ala Leu Glu 
    370                 375                 380                 


Lys Ala Asp Ser Asp Thr Tyr Thr Cys Asp Ile Gly Gln Ala Gln Ser 
385                 390                 395                 400 


Arg Ala Gln Leu Leu Val Gln Gly Glu Ala Ala Lys Cys Ala Arg Ala 
                405                 410                 415     


<210> 6074
<211> 709
<212> PRT
<213> Homo sapiens

<400> 6074
Met Glu Lys His Arg Gly Val Leu Glu Cys Gln Val Ser Arg Ala Ser 
1               5                   10                  15      


Ala Gln Val Arg Trp Phe Lys Gly Ser Gln Glu Leu Gln Pro Gly Pro 
            20                  25                  30          


Lys Tyr Glu Leu Val Ser Asp Gly Leu Tyr Arg Lys Leu Ile Ile Ser 
        35                  40                  45              


Asp Val His Ala Glu Asp Glu Asp Thr Tyr Thr Cys Asp Ala Gly Asp 
    50                  55                  60                  


Val Lys Thr Ser Ala Gln Phe Phe Val Glu Glu Gln Ser Ile Thr Ile 
65                  70                  75                  80  


Val Arg Gly Leu Gln Asp Val Thr Val Met Glu Pro Ala Pro Ala Trp 
                85                  90                  95      


Phe Glu Cys Glu Thr Ser Ile Pro Ser Val Arg Pro Pro Lys Trp Leu 
            100                 105                 110         


Leu Gly Lys Thr Val Leu Gln Ala Gly Gly Asn Val Gly Leu Glu Gln 
        115                 120                 125             


Glu Gly Thr Val His Arg Leu Met Leu Arg Arg Thr Cys Ser Thr Met 
    130                 135                 140                 


Thr Gly Pro Val His Phe Thr Val Gly Lys Ser Arg Ser Ser Ala Arg 
145                 150                 155                 160 


Leu Val Val Ser Asp Ile Pro Val Val Leu Thr Arg Pro Leu Glu Pro 
                165                 170                 175     


Lys Thr Gly Arg Glu Leu Gln Ser Val Val Leu Ser Cys Asp Phe Arg 
            180                 185                 190         


Pro Ala Pro Lys Ala Val Gln Trp Tyr Lys Asp Asp Thr Pro Leu Ser 
        195                 200                 205             


Pro Ser Glu Lys Phe Lys Met Ser Leu Glu Gly Gln Met Ala Glu Leu 
    210                 215                 220                 


Arg Ile Leu Arg Leu Met Pro Ala Asp Ala Gly Val Tyr Arg Cys Gln 
225                 230                 235                 240 


Ala Gly Ser Ala His Ser Ser Thr Glu Val Thr Val Glu Ala Arg Glu 
                245                 250                 255     


Val Thr Val Thr Gly Pro Leu Gln Asp Ala Glu Ala Thr Glu Glu Gly 
            260                 265                 270         


Trp Ala Ser Phe Ser Cys Glu Leu Ser His Glu Asp Glu Glu Val Glu 
        275                 280                 285             


Trp Ser Leu Asn Gly Met Pro Leu Tyr Asn Asp Ser Phe His Glu Ile 
    290                 295                 300                 


Ser His Lys Gly Arg Arg His Thr Leu Val Leu Lys Ser Ile Gln Arg 
305                 310                 315                 320 


Ala Asp Ala Gly Ile Val Arg Ala Ser Ser Leu Lys Val Ser Thr Ser 
                325                 330                 335     


Ala Arg Leu Glu Val Arg Val Lys Pro Val Val Phe Leu Lys Ala Leu 
            340                 345                 350         


Asp Asp Leu Ser Ala Glu Glu Arg Gly Thr Leu Ala Leu Gln Cys Glu 
        355                 360                 365             


Val Ser Asp Pro Glu Ala His Val Val Trp Arg Lys Asp Gly Val Gln 
    370                 375                 380                 


Leu Gly Pro Ser Asp Lys Tyr Asp Phe Leu His Thr Ala Gly Thr Arg 
385                 390                 395                 400 


Gly Leu Val Val His Asp Val Ser Pro Glu Asp Ala Gly Leu Tyr Thr 
                405                 410                 415     


Cys His Val Gly Ser Glu Glu Thr Arg Ala Arg Val Arg Val His Asp 
            420                 425                 430         


Leu His Val Gly Ile Thr Lys Arg Leu Lys Thr Met Glu Val Leu Glu 
        435                 440                 445             


Gly Glu Ser Cys Ser Phe Glu Cys Val Leu Ser His Glu Ser Ala Ser 
    450                 455                 460                 


Asp Pro Ala Met Trp Thr Val Gly Gly Lys Thr Val Gly Ser Ser Ser 
465                 470                 475                 480 


Arg Phe Gln Ala Thr Arg Gln Gly Arg Lys Tyr Ile Leu Val Val Arg 
                485                 490                 495     


Glu Ala Ala Pro Ser Asp Ala Gly Glu Val Val Phe Ser Val Arg Gly 
            500                 505                 510         


Leu Thr Ser Lys Ala Ser Leu Ile Val Arg Glu Arg Pro Ala Ala Ile 
        515                 520                 525             


Ile Lys Pro Leu Glu Asp Gln Trp Val Ala Pro Gly Glu Asp Val Glu 
    530                 535                 540                 


Leu Arg Cys Glu Leu Ser Arg Ala Gly Thr Pro Val His Trp Leu Lys 
545                 550                 555                 560 


Asp Arg Lys Ala Ile Arg Lys Ser Gln Lys Tyr Asp Val Val Cys Glu 
                565                 570                 575     


Gly Thr Met Ala Met Leu Val Ile Arg Gly Ala Ser Leu Lys Asp Ala 
            580                 585                 590         


Gly Glu Tyr Thr Cys Glu Val Glu Ala Ser Lys Ser Thr Ala Ser Leu 
        595                 600                 605             


His Val Glu Glu Lys Ala Asn Cys Phe Thr Glu Glu Leu Thr Asn Leu 
    610                 615                 620                 


Gln Val Glu Glu Lys Gly Thr Ala Val Phe Thr Cys Lys Thr Glu His 
625                 630                 635                 640 


Pro Ala Ala Thr Val Thr Trp Arg Lys Gly Leu Leu Glu Leu Arg Ala 
                645                 650                 655     


Ser Gly Lys His Gln Pro Ser Gln Glu Gly Leu Thr Leu Arg Leu Thr 
            660                 665                 670         


Ile Ser Ala Leu Glu Lys Ala Asp Ser Asp Thr Tyr Thr Cys Asp Ile 
        675                 680                 685             


Gly Gln Ala Gln Ser Arg Ala Gln Leu Leu Val Gln Gly Glu Ala Ala 
    690                 695                 700                 


Lys Cys Ala Arg Ala 
705                 


<210> 6075
<211> 5602
<212> PRT
<213> Homo sapiens

<400> 6075
Met Leu Val Ile Arg Gly Ala Ser Leu Lys Asp Ala Gly Glu Tyr Thr 
1               5                   10                  15      


Cys Glu Val Glu Ala Ser Lys Ser Thr Ala Ser Leu His Val Glu Glu 
            20                  25                  30          


Lys Ala Asn Cys Phe Thr Glu Glu Leu Thr Asn Leu Gln Val Glu Glu 
        35                  40                  45              


Lys Gly Thr Ala Val Phe Thr Cys Lys Thr Glu His Pro Ala Ala Thr 
    50                  55                  60                  


Val Thr Trp Arg Lys Gly Leu Leu Glu Leu Arg Ala Ser Gly Lys His 
65                  70                  75                  80  


Gln Pro Ser Gln Glu Gly Leu Thr Leu Arg Leu Thr Ile Ser Ala Leu 
                85                  90                  95      


Glu Lys Ala Asp Ser Asp Thr Tyr Thr Cys Asp Ile Gly Gln Ala Gln 
            100                 105                 110         


Ser Arg Ala Gln Leu Leu Val Gln Gly Arg Arg Val His Ile Ile Glu 
        115                 120                 125             


Asp Leu Glu Asp Val Asp Val Gln Glu Gly Ser Ser Ala Thr Phe Arg 
    130                 135                 140                 


Cys Arg Ile Ser Pro Ala Asn Tyr Glu Pro Val His Trp Phe Leu Asp 
145                 150                 155                 160 


Lys Thr Pro Leu His Ala Asn Glu Leu Asn Glu Ile Asp Ala Gln Pro 
                165                 170                 175     


Gly Gly Tyr His Val Leu Thr Leu Arg Gln Leu Ala Leu Lys Asp Ser 
            180                 185                 190         


Gly Thr Ile Tyr Phe Glu Ala Gly Asp Gln Arg Ala Ser Ala Ala Leu 
        195                 200                 205             


Arg Val Thr Glu Lys Pro Ser Val Phe Ser Arg Glu Leu Thr Asp Ala 
    210                 215                 220                 


Thr Ile Thr Glu Gly Glu Asp Leu Thr Leu Val Cys Glu Thr Ser Thr 
225                 230                 235                 240 


Cys Asp Ile Pro Val Cys Trp Thr Lys Asp Gly Lys Thr Leu Arg Gly 
                245                 250                 255     


Ser Ala Arg Cys Gln Leu Ser His Glu Gly His Arg Ala Gln Leu Leu 
            260                 265                 270         


Ile Thr Gly Ala Thr Leu Gln Asp Ser Gly Arg Tyr Lys Cys Glu Ala 
        275                 280                 285             


Gly Gly Ala Cys Ser Ser Ser Ile Val Arg Val His Ala Arg Pro Val 
    290                 295                 300                 


Arg Phe Gln Glu Ala Leu Lys Asp Leu Glu Val Leu Glu Gly Gly Ala 
305                 310                 315                 320 


Ala Thr Leu Arg Cys Val Leu Ser Ser Val Ala Ala Pro Val Lys Trp 
                325                 330                 335     


Cys Tyr Gly Asn Asn Val Leu Arg Pro Gly Asp Lys Tyr Ser Leu Arg 
            340                 345                 350         


Gln Glu Gly Ala Met Leu Glu Leu Val Val Arg Asn Leu Arg Pro Gln 
        355                 360                 365             


Asp Ser Gly Arg Tyr Ser Cys Ser Phe Gly Asp Gln Thr Thr Ser Ala 
    370                 375                 380                 


Thr Leu Thr Val Thr Ala Leu Pro Ala Gln Phe Ile Gly Lys Leu Arg 
385                 390                 395                 400 


Asn Lys Glu Ala Thr Glu Gly Ala Thr Ala Thr Leu Arg Cys Glu Leu 
                405                 410                 415     


Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu Arg 
            420                 425                 430         


Asp Gly Asp Arg Tyr Cys Leu Arg Gln Asp Gly Ala Met Cys Glu Leu 
        435                 440                 445             


Gln Ile Arg Gly Leu Ala Met Val Asp Ala Ala Glu Tyr Ser Cys Val 
    450                 455                 460                 


Cys Gly Glu Glu Arg Thr Ser Ala Ser Leu Thr Ile Arg Pro Met Pro 
465                 470                 475                 480 


Ala His Phe Ile Gly Arg Leu Arg His Gln Glu Ser Ile Glu Gly Ala 
                485                 490                 495     


Thr Ala Thr Leu Arg Cys Glu Leu Ser Lys Ala Ala Pro Val Glu Trp 
            500                 505                 510         


Arg Lys Gly Arg Glu Ser Leu Arg Asp Gly Asp Arg His Ser Leu Arg 
        515                 520                 525             


Gln Asp Gly Ala Val Cys Glu Leu Gln Ile Cys Gly Leu Ala Val Ala 
    530                 535                 540                 


Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Glu Glu Arg Thr Ser Ala 
545                 550                 555                 560 


Thr Leu Thr Val Lys Ala Leu Pro Ala Lys Phe Thr Glu Gly Leu Arg 
                565                 570                 575     


Asn Glu Glu Ala Val Glu Gly Ala Thr Ala Met Leu Trp Cys Glu Leu 
            580                 585                 590         


Ser Lys Val Ala Pro Val Glu Trp Arg Lys Gly Pro Glu Asn Leu Arg 
        595                 600                 605             


Asp Gly Asp Arg Tyr Ile Leu Arg Gln Glu Gly Thr Arg Cys Glu Leu 
    610                 615                 620                 


Gln Ile Cys Gly Leu Ala Met Ala Asp Ala Gly Glu Tyr Leu Cys Val 
625                 630                 635                 640 


Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Ile Arg Ala Leu Pro 
                645                 650                 655     


Ala Arg Phe Ile Glu Asp Val Lys Asn Gln Glu Ala Arg Glu Gly Ala 
            660                 665                 670         


Thr Ala Val Leu Gln Cys Glu Leu Asn Ser Ala Ala Pro Val Glu Trp 
        675                 680                 685             


Arg Lys Gly Ser Glu Thr Leu Arg Asp Gly Asp Arg Tyr Ser Leu Arg 
    690                 695                 700                 


Gln Asp Gly Thr Lys Cys Glu Leu Gln Ile Arg Gly Leu Ala Met Ala 
705                 710                 715                 720 


Asp Thr Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser Ala 
                725                 730                 735     


Met Leu Thr Val Arg Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu Arg 
            740                 745                 750         


Asn Glu Glu Ala Thr Glu Gly Ala Thr Ala Val Leu Arg Cys Glu Leu 
        755                 760                 765             


Ser Lys Met Ala Pro Val Glu Trp Trp Lys Gly His Glu Thr Leu Arg 
    770                 775                 780                 


Asp Gly Asp Arg His Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu Leu 
785                 790                 795                 800 


Gln Ile Arg Gly Leu Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys Met 
                805                 810                 815     


Cys Gly Lys Glu Arg Thr Ser Ala Met Leu Thr Val Arg Ala Met Pro 
            820                 825                 830         


Ser Lys Phe Ile Glu Gly Leu Arg Asn Glu Glu Ala Thr Glu Gly Asp 
        835                 840                 845             


Thr Ala Thr Leu Trp Cys Glu Leu Ser Lys Ala Ala Pro Val Glu Trp 
    850                 855                 860                 


Arg Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His Ser Leu Arg 
865                 870                 875                 880 


Gln Asp Gly Ser Arg Cys Glu Leu Gln Ile Arg Gly Leu Ala Val Val 
                885                 890                 895     


Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser Ala 
            900                 905                 910         


Thr Leu Thr Val Arg Ala Leu Pro Ala Arg Phe Ile Glu Asp Val Lys 
        915                 920                 925             


Asn Gln Glu Ala Arg Glu Gly Ala Thr Ala Val Leu Gln Cys Glu Leu 
    930                 935                 940                 


Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu Arg 
945                 950                 955                 960 


Gly Gly Asp Arg Tyr Ser Leu Arg Gln Asp Gly Thr Arg Cys Glu Leu 
                965                 970                 975     


Gln Ile His Gly Leu Ser Val Ala Asp Thr Gly Glu Tyr Ser Cys Val 
            980                 985                 990         


Cys Gly Gln Glu Arg Thr Ser Ala  Thr Leu Thr Val Arg  Ala Leu Pro 
        995                 1000                 1005             


Ala Arg  Phe Thr Gln Asp Leu  Lys Thr Lys Glu Ala  Ser Glu Gly 
    1010                 1015                 1020             


Ala Thr  Ala Thr Leu Gln Cys  Glu Leu Ser Lys Val  Ala Pro Val 
    1025                 1030                 1035             


Glu Trp  Lys Lys Gly Pro Glu  Thr Leu Arg Asp Gly  Gly Arg Tyr 
    1040                 1045                 1050             


Ser Leu  Lys Gln Asp Gly Thr  Arg Cys Glu Leu Gln  Ile His Asp 
    1055                 1060                 1065             


Leu Ser  Val Ala Asp Ala Gly  Glu Tyr Ser Cys Met  Cys Gly Gln 
    1070                 1075                 1080             


Glu Arg  Thr Ser Ala Thr Leu  Thr Val Arg Ala Leu  Pro Ala Arg 
    1085                 1090                 1095             


Phe Thr  Glu Gly Leu Arg Asn  Glu Glu Ala Met Glu  Gly Ala Thr 
    1100                 1105                 1110             


Ala Thr  Leu Gln Cys Glu Leu  Ser Lys Ala Ala Pro  Val Glu Trp 
    1115                 1120                 1125             


Arg Lys  Gly Leu Glu Ala Leu  Arg Asp Gly Asp Lys  Tyr Ser Leu 
    1130                 1135                 1140             


Arg Gln  Asp Gly Ala Val Cys  Glu Leu Gln Ile His  Gly Leu Ala 
    1145                 1150                 1155             


Met Ala  Asp Asn Gly Val Tyr  Ser Cys Val Cys Gly  Gln Glu Arg 
    1160                 1165                 1170             


Thr Ser  Ala Thr Leu Thr Val  Arg Ala Leu Pro Ala  Arg Phe Ile 
    1175                 1180                 1185             


Glu Asp  Met Arg Asn Gln Lys  Ala Thr Glu Gly Ala  Thr Val Thr 
    1190                 1195                 1200             


Leu Gln  Cys Lys Leu Arg Lys  Ala Ala Pro Val Glu  Trp Arg Lys 
    1205                 1210                 1215             


Gly Pro  Asn Thr Leu Lys Asp  Gly Asp Arg Tyr Ser  Leu Lys Gln 
    1220                 1225                 1230             


Asp Gly  Thr Ser Cys Glu Leu  Gln Ile Arg Gly Leu  Val Ile Ala 
    1235                 1240                 1245             


Asp Ala  Gly Glu Tyr Ser Cys  Ile Cys Glu Gln Glu  Arg Thr Ser 
    1250                 1255                 1260             


Ala Thr  Leu Thr Val Arg Ala  Leu Pro Ala Arg Phe  Ile Glu Asp 
    1265                 1270                 1275             


Val Arg  Asn His Glu Ala Thr  Glu Gly Ala Thr Ala  Val Leu Gln 
    1280                 1285                 1290             


Cys Glu  Leu Ser Lys Ala Ala  Pro Val Glu Trp Arg  Lys Gly Ser 
    1295                 1300                 1305             


Glu Thr  Leu Arg Asp Gly Asp  Arg Tyr Ser Leu Arg  Gln Asp Gly 
    1310                 1315                 1320             


Thr Arg  Cys Glu Leu Gln Ile  Arg Gly Leu Ala Val  Glu Asp Thr 
    1325                 1330                 1335             


Gly Glu  Tyr Leu Cys Val Cys  Gly Gln Glu Arg Thr  Ser Ala Thr 
    1340                 1345                 1350             


Leu Thr  Val Arg Ala Leu Pro  Ala Arg Phe Ile Asp  Asn Met Thr 
    1355                 1360                 1365             


Asn Gln  Glu Ala Arg Glu Gly  Ala Thr Ala Thr Leu  His Cys Glu 
    1370                 1375                 1380             


Leu Ser  Lys Val Ala Pro Val  Glu Trp Arg Lys Gly  Pro Glu Thr 
    1385                 1390                 1395             


Leu Arg  Asp Gly Asp Arg His  Ser Leu Arg Gln Asp  Gly Thr Arg 
    1400                 1405                 1410             


Cys Glu  Leu Gln Ile Arg Gly  Leu Ser Val Ala Asp  Ala Gly Glu 
    1415                 1420                 1425             


Tyr Ser  Cys Val Cys Gly Gln  Glu Arg Thr Ser Ala  Thr Leu Thr 
    1430                 1435                 1440             


Ile Arg  Glu Ala Thr Glu Gly  Ala Thr Ala Met Leu  Gln Cys Glu 
    1445                 1450                 1455             


Leu Ser  Lys Val Ala Pro Val  Glu Trp Arg Lys Gly  Pro Glu Thr 
    1460                 1465                 1470             


Leu Arg  Asp Gly Asp Arg Tyr  Asn Leu Arg Gln Asp  Gly Thr Arg 
    1475                 1480                 1485             


Cys Glu  Leu Gln Ile His Gly  Leu Ser Val Ala Asp  Thr Gly Glu 
    1490                 1495                 1500             


Tyr Ser  Cys Val Cys Gly Gln  Glu Lys Thr Ser Ala  Thr Leu Thr 
    1505                 1510                 1515             


Val Lys  Ala Pro Gln Pro Val  Phe Arg Glu Pro Leu  Gln Ser Leu 
    1520                 1525                 1530             


Gln Ala  Glu Glu Gly Ser Thr  Ala Thr Leu Gln Cys  Glu Leu Ser 
    1535                 1540                 1545             


Glu Pro  Thr Ala Thr Val Val  Trp Ser Lys Gly Gly  Leu Gln Leu 
    1550                 1555                 1560             


Gln Ala  Asn Gly Arg Arg Glu  Pro Arg Leu Gln Gly  Cys Thr Ala 
    1565                 1570                 1575             


Glu Leu  Val Leu Gln Asp Leu  Gln Arg Glu Asp Thr  Gly Glu Tyr 
    1580                 1585                 1590             


Thr Cys  Thr Cys Gly Ser Gln  Ala Thr Ser Ala Thr  Leu Thr Val 
    1595                 1600                 1605             


Thr Ala  Ala Pro Val Arg Phe  Leu Arg Glu Leu Gln  His Gln Glu 
    1610                 1615                 1620             


Val Asp  Glu Gly Gly Thr Ala  His Leu Cys Cys Glu  Leu Ser Arg 
    1625                 1630                 1635             


Ala Gly  Ala Ser Val Glu Trp  Arg Lys Gly Ser Leu  Gln Leu Phe 
    1640                 1645                 1650             


Pro Cys  Ala Lys Tyr Gln Met  Val Gln Asp Gly Ala  Ala Ala Glu 
    1655                 1660                 1665             


Leu Leu  Val Arg Gly Val Glu  Gln Glu Asp Ala Gly  Asp Tyr Thr 
    1670                 1675                 1680             


Cys Asp  Thr Gly His Thr Gln  Ser Met Ala Ser Leu  Ser Val Arg 
    1685                 1690                 1695             


Val Pro  Arg Pro Lys Phe Lys  Thr Arg Leu Gln Ser  Leu Glu Gln 
    1700                 1705                 1710             


Glu Thr  Gly Asp Ile Ala Arg  Leu Cys Cys Gln Leu  Ser Asp Ala 
    1715                 1720                 1725             


Glu Ser  Gly Ala Val Val Gln  Trp Leu Lys Glu Gly  Val Glu Leu 
    1730                 1735                 1740             


His Ala  Gly Pro Lys Tyr Glu  Met Arg Ser Gln Gly  Ala Thr Arg 
    1745                 1750                 1755             


Glu Leu  Leu Ile His Gln Leu  Glu Ala Lys Asp Thr  Gly Glu Tyr 
    1760                 1765                 1770             


Ala Cys  Val Thr Gly Gly Gln  Lys Thr Ala Ala Ser  Leu Arg Val 
    1775                 1780                 1785             


Thr Glu  Pro Glu Val Thr Ile  Val Arg Gly Leu Val  Asp Ala Glu 
    1790                 1795                 1800             


Val Thr  Ala Asp Glu Asp Val  Glu Phe Ser Cys Glu  Val Ser Arg 
    1805                 1810                 1815             


Ala Gly  Ala Thr Gly Val Gln  Trp Cys Leu Gln Gly  Leu Pro Leu 
    1820                 1825                 1830             


Gln Ser  Asn Glu Val Thr Glu  Val Ala Val Arg Asp  Gly Arg Ile 
    1835                 1840                 1845             


His Thr  Leu Arg Leu Lys Gly  Val Thr Pro Glu Asp  Ala Gly Thr 
    1850                 1855                 1860             


Val Ser  Phe His Leu Gly Asn  His Ala Ser Ser Ala  Gln Leu Thr 
    1865                 1870                 1875             


Val Arg  Ala Pro Glu Val Thr  Ile Leu Glu Pro Leu  Gln Asp Val 
    1880                 1885                 1890             


Gln Leu  Ser Glu Gly Gln Asp  Ala Ser Phe Gln Cys  Arg Leu Ser 
    1895                 1900                 1905             


Arg Ala  Ser Gly Gln Glu Ala  Arg Trp Ala Leu Gly  Gly Val Pro 
    1910                 1915                 1920             


Leu Gln  Ala Asn Glu Met Asn  Asp Ile Thr Val Glu  Gln Gly Thr 
    1925                 1930                 1935             


Leu His  Leu Leu Thr Leu His  Lys Val Thr Leu Glu  Asp Ala Gly 
    1940                 1945                 1950             


Thr Val  Ser Phe His Val Gly  Thr Cys Ser Ser Glu  Ala Gln Leu 
    1955                 1960                 1965             


Lys Val  Thr Ala Lys Asn Thr  Val Val Arg Gly Leu  Glu Asn Val 
    1970                 1975                 1980             


Glu Ala  Leu Glu Gly Gly Glu  Ala Leu Phe Glu Cys  Gln Leu Ser 
    1985                 1990                 1995             


Gln Pro  Glu Val Ala Ala His  Thr Trp Leu Leu Asp  Asp Glu Pro 
    2000                 2005                 2010             


Val His  Thr Ser Glu Asn Ala  Glu Val Val Phe Phe  Glu Asn Gly 
    2015                 2020                 2025             


Leu Arg  His Leu Leu Leu Leu  Lys Asn Leu Arg Pro  Gln Asp Ser 
    2030                 2035                 2040             


Cys Arg  Val Thr Phe Leu Ala  Gly Asp Met Val Thr  Ser Ala Phe 
    2045                 2050                 2055             


Leu Thr  Val Arg Gly Trp Arg  Leu Glu Ile Leu Glu  Pro Leu Lys 
    2060                 2065                 2070             


Asn Ala  Ala Val Arg Ala Gly  Ala Gln Ala Cys Phe  Thr Cys Thr 
    2075                 2080                 2085             


Leu Ser  Glu Ala Val Pro Val  Gly Glu Ala Ser Trp  Tyr Ile Asn 
    2090                 2095                 2100             


Gly Ala  Ala Val Gln Pro Asp  Asp Ser Asp Trp Thr  Val Thr Ala 
    2105                 2110                 2115             


Asp Gly  Ser His His Ala Leu  Leu Leu Arg Ser Ala  Gln Pro His 
    2120                 2125                 2130             


His Ala  Gly Glu Val Thr Phe  Ala Cys Arg Asp Ala  Val Ala Ser 
    2135                 2140                 2145             


Ala Arg  Leu Thr Val Leu Gly  Leu Pro Asp Pro Pro  Glu Asp Ala 
    2150                 2155                 2160             


Glu Val  Val Ala Arg Ser Ser  His Thr Val Thr Leu  Ser Trp Ala 
    2165                 2170                 2175             


Ala Pro  Met Ser Asp Gly Gly  Gly Gly Leu Cys Gly  Tyr Arg Val 
    2180                 2185                 2190             


Glu Val  Lys Glu Gly Ala Thr  Gly Gln Trp Arg Leu  Cys His Glu 
    2195                 2200                 2205             


Leu Val  Pro Gly Pro Glu Cys  Val Val Asp Gly Leu  Ala Pro Gly 
    2210                 2215                 2220             


Glu Thr  Tyr Arg Phe Arg Val  Ala Ala Val Gly Pro  Val Gly Ala 
    2225                 2230                 2235             


Gly Glu  Pro Val His Leu Pro  Gln Thr Val Arg Leu  Ala Glu Pro 
    2240                 2245                 2250             


Pro Lys  Pro Val Pro Pro Gln  Pro Ser Ala Pro Glu  Ser Arg Gln 
    2255                 2260                 2265             


Val Ala  Ala Gly Glu Asp Val  Ser Leu Glu Leu Glu  Val Val Ala 
    2270                 2275                 2280             


Glu Ala  Gly Glu Val Ile Trp  His Lys Gly Met Glu  Arg Ile Gln 
    2285                 2290                 2295             


Pro Gly  Gly Arg Phe Glu Val  Val Ser Gln Gly Arg  Gln Gln Met 
    2300                 2305                 2310             


Leu Val  Ile Lys Gly Phe Thr  Ala Glu Asp Gln Gly  Glu Tyr His 
    2315                 2320                 2325             


Cys Gly  Leu Ala Gln Gly Ser  Ile Cys Pro Ala Ala  Ala Thr Phe 
    2330                 2335                 2340             


Gln Val  Ala Leu Ser Pro Ala  Ser Val Asp Glu Ala  Pro Gln Pro 
    2345                 2350                 2355             


Ser Leu  Pro Pro Glu Ala Ala  Gln Glu Gly Asp Leu  His Leu Leu 
    2360                 2365                 2370             


Trp Glu  Ala Leu Ala Arg Lys  Arg Arg Met Ser Arg  Glu Pro Thr 
    2375                 2380                 2385             


Leu Asp  Ser Ile Ser Glu Leu  Pro Glu Glu Asp Gly  Arg Ser Gln 
    2390                 2395                 2400             


Arg Leu  Pro Gln Glu Ala Glu  Glu Val Ala Pro Asp  Leu Ser Glu 
    2405                 2410                 2415             


Gly Tyr  Ser Thr Ala Asp Glu  Leu Ala Arg Thr Gly  Asp Ala Asp 
    2420                 2425                 2430             


Leu Ser  His Thr Ser Ser Asp  Asp Glu Ser Arg Ala  Gly Thr Pro 
    2435                 2440                 2445             


Ser Leu  Val Thr Tyr Leu Lys  Lys Ala Gly Arg Pro  Gly Thr Ser 
    2450                 2455                 2460             


Pro Leu  Ala Ser Lys Val Gly  Ala Pro Ala Ala Pro  Ser Val Lys 
    2465                 2470                 2475             


Pro Gln  Gln Gln Gln Glu Pro  Leu Ala Ala Val Arg  Pro Pro Leu 
    2480                 2485                 2490             


Gly Asp  Leu Ser Thr Lys Asp  Leu Gly Asp Pro Ser  Met Asp Lys 
    2495                 2500                 2505             


Ala Ala  Val Lys Ile Gln Ala  Ala Phe Lys Gly Tyr  Lys Val Arg 
    2510                 2515                 2520             


Lys Glu  Met Lys Gln Gln Glu  Gly Pro Met Phe Ser  His Thr Phe 
    2525                 2530                 2535             


Gly Asp  Thr Glu Ala Gln Val  Gly Asp Ala Leu Arg  Leu Glu Cys 
    2540                 2545                 2550             


Val Val  Ala Ser Lys Ala Asp  Val Arg Ala Arg Trp  Leu Lys Asp 
    2555                 2560                 2565             


Gly Val  Glu Leu Thr Asp Gly  Arg His His His Ile  Asp Gln Leu 
    2570                 2575                 2580             


Gly Asp  Gly Thr Cys Ser Leu  Leu Ile Thr Gly Leu  Asp Arg Ala 
    2585                 2590                 2595             


Asp Ala  Gly Cys Tyr Thr Cys  Gln Val Ser Asn Lys  Phe Gly Gln 
    2600                 2605                 2610             


Val Thr  His Ser Ala Cys Val  Val Val Ser Gly Ser  Glu Ser Glu 
    2615                 2620                 2625             


Ala Glu  Ser Ser Ser Gly Gly  Glu Leu Asp Asp Ala  Phe Arg Arg 
    2630                 2635                 2640             


Ala Ala  Arg Arg Leu His Arg  Leu Phe Arg Thr Lys  Ser Pro Ala 
    2645                 2650                 2655             


Glu Val  Ser Asp Glu Glu Leu  Phe Leu Ser Ala Asp  Glu Gly Pro 
    2660                 2665                 2670             


Ala Glu  Pro Glu Glu Pro Ala  Asp Trp Gln Thr Tyr  Arg Glu Asp 
    2675                 2680                 2685             


Glu His  Phe Ile Cys Ile Arg  Phe Glu Ala Leu Thr  Glu Ala Arg 
    2690                 2695                 2700             


Gln Ala  Val Thr Arg Phe Gln  Glu Met Phe Ala Thr  Leu Gly Ile 
    2705                 2710                 2715             


Gly Val  Glu Ile Lys Leu Val  Glu Gln Gly Pro Arg  Arg Val Glu 
    2720                 2725                 2730             


Met Cys  Ile Ser Lys Glu Thr  Pro Ala Pro Val Val  Pro Pro Glu 
    2735                 2740                 2745             


Pro Leu  Pro Ser Leu Leu Thr  Ser Asp Ala Ala Pro  Val Phe Leu 
    2750                 2755                 2760             


Thr Glu  Leu Gln Asn Gln Glu  Val Gln Asp Gly Tyr  Pro Val Ser 
    2765                 2770                 2775             


Phe Asp  Cys Val Val Thr Gly  Gln Pro Met Pro Ser  Val Arg Trp 
    2780                 2785                 2790             


Phe Lys  Asp Gly Lys Leu Leu  Glu Glu Asp Asp His  Tyr Met Ile 
    2795                 2800                 2805             


Asn Glu  Asp Gln Gln Gly Gly  His Gln Leu Ile Ile  Thr Ala Val 
    2810                 2815                 2820             


Val Pro  Ala Asp Met Gly Val  Tyr Arg Cys Leu Ala  Glu Asn Ser 
    2825                 2830                 2835             


Met Gly  Val Ser Ser Thr Lys  Ala Glu Leu Arg Val  Asp Leu Thr 
    2840                 2845                 2850             


Ser Thr  Asp Tyr Asp Thr Ala  Ala Asp Ala Thr Glu  Ser Ser Ser 
    2855                 2860                 2865             


Tyr Phe  Ser Ala Gln Gly Tyr  Leu Ser Ser Arg Glu  Gln Glu Gly 
    2870                 2875                 2880             


Thr Glu  Ser Thr Thr Asp Glu  Gly Gln Leu Pro Gln  Val Val Glu 
    2885                 2890                 2895             


Glu Leu  Arg Asp Leu Gln Val  Ala Pro Gly Thr Arg  Leu Ala Lys 
    2900                 2905                 2910             


Phe Gln  Leu Lys Val Lys Gly  Tyr Pro Ala Pro Arg  Leu Tyr Trp 
    2915                 2920                 2925             


Phe Lys  Asp Gly Gln Pro Leu  Thr Ala Ser Ala His  Ile Arg Met 
    2930                 2935                 2940             


Thr Asp  Lys Lys Ile Leu His  Thr Leu Glu Ile Ile  Ser Val Thr 
    2945                 2950                 2955             


Arg Glu  Asp Ser Gly Gln Tyr  Ala Ala Tyr Ile Ser  Asn Ala Met 
    2960                 2965                 2970             


Gly Ala  Ala Tyr Ser Ser Ala  Arg Leu Leu Val Arg  Gly Pro Asp 
    2975                 2980                 2985             


Glu Pro  Glu Glu Lys Pro Ala  Ser Asp Val His Glu  Gln Leu Val 
    2990                 2995                 3000             


Pro Pro  Arg Met Leu Glu Arg  Phe Thr Pro Lys Lys  Val Lys Lys 
    3005                 3010                 3015             


Gly Ser  Ser Ile Thr Phe Ser  Val Lys Val Glu Gly  Arg Pro Val 
    3020                 3025                 3030             


Pro Thr  Val His Trp Leu Arg  Glu Glu Ala Glu Arg  Gly Val Leu 
    3035                 3040                 3045             


Trp Ile  Gly Pro Asp Thr Pro  Gly Tyr Thr Val Ala  Ser Ser Ala 
    3050                 3055                 3060             


Gln Gln  His Ser Leu Val Leu  Leu Asp Val Gly Arg  Gln His Gln 
    3065                 3070                 3075             


Gly Thr  Tyr Thr Cys Ile Ala  Ser Asn Ala Ala Gly  Gln Ala Leu 
    3080                 3085                 3090             


Cys Ser  Ala Ser Leu His Val  Ser Gly Leu Pro Lys  Val Glu Glu 
    3095                 3100                 3105             


Gln Glu  Lys Val Lys Glu Ala  Leu Ile Ser Thr Phe  Leu Gln Gly 
    3110                 3115                 3120             


Thr Thr  Gln Ala Ile Ser Ala  Gln Gly Leu Glu Thr  Ala Ser Phe 
    3125                 3130                 3135             


Ala Asp  Leu Gly Gly Gln Arg  Lys Glu Glu Pro Leu  Ala Ala Lys 
    3140                 3145                 3150             


Glu Ala  Leu Gly His Leu Ser  Leu Ala Glu Val Gly  Thr Glu Glu 
    3155                 3160                 3165             


Phe Leu  Gln Lys Leu Thr Ser  Gln Ile Thr Glu Met  Val Ser Ala 
    3170                 3175                 3180             


Lys Ile  Thr Gln Ala Lys Leu  Gln Val Pro Gly Gly  Asp Ser Asp 
    3185                 3190                 3195             


Glu Asp  Ser Lys Thr Pro Ser  Ala Ser Pro Arg His  Gly Arg Ser 
    3200                 3205                 3210             


Arg Pro  Ser Ser Ser Ile Gln  Glu Ser Ser Ser Glu  Ser Glu Asp 
    3215                 3220                 3225             


Gly Asp  Ala Arg Gly Glu Ile  Phe Asp Ile Tyr Val  Val Thr Ala 
    3230                 3235                 3240             


Asp Tyr  Leu Pro Leu Gly Ala  Glu Gln Asp Ala Ile  Thr Leu Arg 
    3245                 3250                 3255             


Glu Gly  Gln Tyr Val Glu Val  Leu Asp Ala Ala His  Pro Leu Arg 
    3260                 3265                 3270             


Trp Leu  Val Arg Thr Lys Pro  Thr Lys Ser Ser Pro  Ser Arg Gln 
    3275                 3280                 3285             


Gly Trp  Val Ser Pro Ala Tyr  Leu Asp Arg Arg Leu  Lys Leu Ser 
    3290                 3295                 3300             


Pro Glu  Trp Gly Ala Ala Glu  Ala Pro Glu Phe Pro  Gly Glu Ala 
    3305                 3310                 3315             


Val Ser  Glu Asp Glu Tyr Lys  Ala Arg Leu Ser Ser  Val Ile Gln 
    3320                 3325                 3330             


Glu Leu  Leu Ser Ser Glu Gln  Ala Phe Val Glu Glu  Leu Gln Phe 
    3335                 3340                 3345             


Leu Gln  Ser His His Leu Gln  His Leu Glu Arg Cys  Pro His Val 
    3350                 3355                 3360             


Pro Ile  Ala Val Ala Gly Gln  Lys Ala Val Ile Phe  Arg Asn Val 
    3365                 3370                 3375             


Arg Asp  Ile Gly Arg Phe His  Ser Ser Phe Leu Gln  Glu Leu Gln 
    3380                 3385                 3390             


Gln Cys  Asp Thr Asp Asp Asp  Val Ala Met Cys Phe  Ile Lys Asn 
    3395                 3400                 3405             


Gln Ala  Ala Phe Glu Gln Tyr  Leu Glu Phe Leu Val  Gly Arg Val 
    3410                 3415                 3420             


Gln Ala  Glu Ser Val Val Val  Ser Thr Ala Ile Gln  Glu Phe Tyr 
    3425                 3430                 3435             


Lys Lys  Tyr Ala Glu Glu Ala  Leu Leu Ala Gly Asp  Pro Ser Gln 
    3440                 3445                 3450             


Pro Pro  Pro Pro Pro Leu Gln  His Tyr Leu Glu Gln  Pro Val Glu 
    3455                 3460                 3465             


Arg Val  Gln Arg Tyr Gln Ala  Leu Leu Lys Glu Leu  Ile Arg Asn 
    3470                 3475                 3480             


Lys Ala  Arg Asn Arg Gln Asn  Cys Ala Leu Leu Glu  Gln Ala Tyr 
    3485                 3490                 3495             


Ala Val  Val Ser Ala Leu Pro  Gln Arg Ala Glu Asn  Lys Leu His 
    3500                 3505                 3510             


Val Ser  Leu Met Glu Asn Tyr  Pro Gly Thr Leu Gln  Ala Leu Gly 
    3515                 3520                 3525             


Glu Pro  Ile Arg Gln Gly His  Phe Ile Val Trp Glu  Gly Ala Pro 
    3530                 3535                 3540             


Gly Ala  Arg Met Pro Trp Lys  Gly His Asn Arg His  Val Phe Leu 
    3545                 3550                 3555             


Phe Arg  Asn His Leu Val Ile  Cys Lys Pro Arg Arg  Asp Ser Arg 
    3560                 3565                 3570             


Thr Asp  Thr Val Ser Tyr Val  Phe Arg Asn Met Met  Lys Leu Ser 
    3575                 3580                 3585             


Ser Ile  Asp Leu Asn Asp Gln  Val Glu Gly Asp Asp  Arg Ala Phe 
    3590                 3595                 3600             


Glu Val  Trp Gln Glu Arg Glu  Asp Ser Val Arg Lys  Tyr Leu Leu 
    3605                 3610                 3615             


Gln Ala  Arg Thr Ala Ile Ile  Lys Ser Ser Trp Val  Lys Glu Ile 
    3620                 3625                 3630             


Cys Gly  Ile Gln Gln Arg Leu  Ala Leu Pro Val Trp  Arg Pro Pro 
    3635                 3640                 3645             


Asp Phe  Glu Glu Glu Leu Ala  Asp Cys Thr Ala Glu  Leu Gly Glu 
    3650                 3655                 3660             


Thr Val  Lys Leu Ala Cys Arg  Val Thr Gly Thr Pro  Lys Pro Val 
    3665                 3670                 3675             


Ile Ser  Trp Tyr Lys Asp Gly  Lys Ala Val Gln Val  Asp Pro His 
    3680                 3685                 3690             


His Ile  Leu Ile Glu Asp Pro  Asp Gly Ser Cys Ala  Leu Ile Leu 
    3695                 3700                 3705             


Asp Ser  Leu Thr Gly Val Asp  Ser Gly Gln Tyr Met  Cys Phe Ala 
    3710                 3715                 3720             


Ala Ser  Ala Ala Gly Asn Cys  Ser Thr Leu Gly Lys  Ile Leu Val 
    3725                 3730                 3735             


Gln Val  Pro Pro Arg Phe Val  Asn Lys Val Arg Ala  Ser Pro Phe 
    3740                 3745                 3750             


Val Glu  Gly Glu Asp Ala Gln  Phe Thr Cys Thr Ile  Glu Gly Ala 
    3755                 3760                 3765             


Pro Tyr  Pro Gln Ile Arg Trp  Tyr Lys Asp Gly Ala  Leu Leu Thr 
    3770                 3775                 3780             


Thr Gly  Asn Lys Phe Gln Thr  Leu Ser Glu Pro Arg  Ser Gly Leu 
    3785                 3790                 3795             


Leu Val  Leu Val Ile Arg Ala  Ala Ser Lys Glu Asp  Leu Gly Leu 
    3800                 3805                 3810             


Tyr Glu  Cys Glu Leu Val Asn  Arg Leu Gly Ser Ala  Arg Ala Ser 
    3815                 3820                 3825             


Ala Glu  Leu Arg Ile Gln Ser  Pro Met Leu Gln Ala  Gln Glu Gln 
    3830                 3835                 3840             


Cys His  Arg Glu Gln Leu Val  Ala Ala Val Glu Asp  Thr Thr Leu 
    3845                 3850                 3855             


Glu Arg  Ala Asp Gln Glu Val  Thr Ser Val Leu Lys  Arg Leu Leu 
    3860                 3865                 3870             


Gly Pro  Lys Ala Pro Gly Pro  Ser Thr Gly Asp Leu  Thr Gly Pro 
    3875                 3880                 3885             


Gly Pro  Cys Pro Arg Gly Ala  Pro Ala Leu Gln Glu  Thr Gly Ser 
    3890                 3895                 3900             


Gln Pro  Pro Val Thr Gly Thr  Ser Glu Ala Pro Ala  Val Pro Pro 
    3905                 3910                 3915             


Arg Val  Pro Gln Pro Leu Leu  His Glu Gly Pro Glu  Gln Glu Pro 
    3920                 3925                 3930             


Glu Ala  Ile Ala Arg Ala Gln  Glu Trp Thr Val Pro  Ile Arg Met 
    3935                 3940                 3945             


Glu Gly  Ala Ala Trp Pro Gly  Ala Gly Thr Gly Glu  Leu Leu Trp 
    3950                 3955                 3960             


Asp Val  His Ser His Val Val  Arg Glu Thr Thr Gln  Arg Thr Tyr 
    3965                 3970                 3975             


Thr Tyr  Gln Ala Ile Asp Thr  His Thr Ala Arg Pro  Pro Ser Met 
    3980                 3985                 3990             


Gln Val  Thr Ile Glu Asp Val  Gln Ala Gln Thr Gly  Gly Thr Ala 
    3995                 4000                 4005             


Gln Phe  Glu Ala Ile Ile Glu  Gly Asp Pro Gln Pro  Ser Val Thr 
    4010                 4015                 4020             


Trp Tyr  Lys Asp Ser Val Gln  Leu Val Asp Ser Thr  Arg Leu Ser 
    4025                 4030                 4035             


Gln Gln  Gln Glu Gly Thr Thr  Tyr Ser Leu Val Leu  Arg His Val 
    4040                 4045                 4050             


Ala Ser  Lys Asp Ala Gly Val  Tyr Thr Cys Leu Ala  Gln Asn Thr 
    4055                 4060                 4065             


Gly Gly  Gln Val Leu Cys Lys  Ala Glu Leu Leu Val  Leu Gly Gly 
    4070                 4075                 4080             


Asp Asn  Glu Pro Asp Ser Glu  Lys Gln Ser His Arg  Arg Lys Leu 
    4085                 4090                 4095             


His Ser  Phe Tyr Glu Val Lys  Glu Glu Ile Gly Arg  Gly Val Phe 
    4100                 4105                 4110             


Gly Phe  Val Lys Arg Val Gln  His Lys Gly Asn Lys  Ile Leu Cys 
    4115                 4120                 4125             


Ala Ala  Lys Phe Ile Pro Leu  Arg Ser Arg Thr Arg  Ala Gln Ala 
    4130                 4135                 4140             


Tyr Arg  Glu Arg Asp Ile Leu  Ala Ala Leu Ser His  Pro Leu Val 
    4145                 4150                 4155             


Thr Gly  Leu Leu Asp Gln Phe  Glu Thr Arg Lys Thr  Leu Ile Leu 
    4160                 4165                 4170             


Ile Leu  Glu Leu Cys Ser Ser  Glu Glu Leu Leu Asp  Arg Leu Tyr 
    4175                 4180                 4185             


Arg Lys  Gly Val Val Thr Glu  Ala Glu Val Lys Val  Tyr Ile Gln 
    4190                 4195                 4200             


Gln Leu  Val Glu Gly Leu His  Tyr Leu His Ser His  Gly Val Leu 
    4205                 4210                 4215             


His Leu  Asp Ile Lys Pro Ser  Asn Ile Leu Met Val  His Pro Ala 
    4220                 4225                 4230             


Arg Glu  Asp Ile Lys Ile Cys  Asp Phe Gly Phe Ala  Gln Asn Ile 
    4235                 4240                 4245             


Thr Pro  Ala Glu Leu Gln Phe  Ser Gln Tyr Gly Ser  Pro Glu Phe 
    4250                 4255                 4260             


Val Ser  Pro Glu Ile Ile Gln  Gln Asn Pro Val Ser  Glu Ala Ser 
    4265                 4270                 4275             


Asp Ile  Trp Ala Met Gly Val  Ile Ser Tyr Leu Ser  Leu Thr Cys 
    4280                 4285                 4290             


Ser Ser  Pro Phe Ala Gly Glu  Ser Asp Arg Ala Thr  Leu Leu Asn 
    4295                 4300                 4305             


Val Leu  Glu Gly Arg Val Ser  Trp Ser Ser Pro Met  Ala Ala His 
    4310                 4315                 4320             


Leu Ser  Glu Asp Ala Lys Asp  Phe Ile Lys Ala Thr  Leu Gln Arg 
    4325                 4330                 4335             


Ala Pro  Gln Ala Arg Pro Ser  Ala Ala Gln Cys Leu  Ser His Pro 
    4340                 4345                 4350             


Trp Phe  Leu Lys Ser Met Pro  Ala Glu Glu Ala His  Phe Ile Asn 
    4355                 4360                 4365             


Thr Lys  Gln Leu Lys Phe Leu  Leu Ala Arg Ser Arg  Trp Gln Arg 
    4370                 4375                 4380             


Ser Leu  Met Ser Tyr Lys Ser  Ile Leu Val Met Arg  Ser Ile Pro 
    4385                 4390                 4395             


Glu Leu  Leu Arg Gly Pro Pro  Asp Ser Pro Ser Leu  Gly Val Ala 
    4400                 4405                 4410             


Arg His  Leu Cys Arg Asp Thr  Gly Gly Ser Ser Ser  Ser Ser Ser 
    4415                 4420                 4425             


Ser Ser  Asp Asn Glu Leu Ala  Pro Phe Ala Arg Ala  Lys Ser Leu 
    4430                 4435                 4440             


Pro Pro  Ser Pro Val Thr His  Ser Pro Leu Leu His  Pro Arg Gly 
    4445                 4450                 4455             


Phe Leu  Arg Pro Ser Ala Ser  Leu Pro Glu Glu Ala  Glu Ala Ser 
    4460                 4465                 4470             


Glu Arg  Ser Thr Glu Ala Pro  Ala Pro Pro Ala Ser  Pro Glu Gly 
    4475                 4480                 4485             


Ala Gly  Pro Pro Ala Ala Gln  Gly Cys Val Pro Arg  His Ser Val 
    4490                 4495                 4500             


Ile Arg  Ser Leu Phe Tyr His  Gln Ala Gly Glu Ser  Pro Glu His 
    4505                 4510                 4515             


Gly Ala  Leu Ala Pro Gly Ser  Arg Arg His Pro Ala  Arg Arg Arg 
    4520                 4525                 4530             


His Leu  Leu Lys Gly Gly Tyr  Ile Ala Gly Ala Leu  Pro Gly Leu 
    4535                 4540                 4545             


Arg Glu  Pro Leu Met Glu His  Arg Val Leu Glu Glu  Glu Ala Ala 
    4550                 4555                 4560             


Arg Glu  Glu Gln Ala Thr Leu  Leu Ala Lys Ala Pro  Ser Phe Glu 
    4565                 4570                 4575             


Thr Ala  Leu Arg Leu Pro Ala  Ser Gly Thr His Leu  Ala Pro Gly 
    4580                 4585                 4590             


His Ser  His Ser Leu Glu His  Asp Ser Pro Ser Thr  Pro Arg Pro 
    4595                 4600                 4605             


Ser Ser  Glu Ala Cys Gly Glu  Ala Gln Arg Leu Pro  Ser Ala Pro 
    4610                 4615                 4620             


Ser Gly  Gly Ala Pro Ile Arg  Asp Met Gly His Pro  Gln Gly Ser 
    4625                 4630                 4635             


Lys Gln  Leu Pro Ser Thr Gly  Gly His Pro Gly Thr  Ala Gln Pro 
    4640                 4645                 4650             


Glu Arg  Pro Ser Pro Asp Ser  Pro Trp Gly Gln Pro  Ala Pro Phe 
    4655                 4660                 4665             


Cys His  Pro Lys Gln Gly Ser  Ala Pro Gln Glu Gly  Cys Ser Pro 
    4670                 4675                 4680             


His Pro  Ala Val Ala Pro Cys  Pro Pro Gly Ser Phe  Pro Pro Gly 
    4685                 4690                 4695             


Ser Cys  Lys Glu Ala Pro Leu  Val Pro Ser Ser Pro  Phe Leu Gly 
    4700                 4705                 4710             


Gln Pro  Gln Ala Pro Pro Ala  Pro Ala Lys Ala Ser  Pro Pro Leu 
    4715                 4720                 4725             


Asp Ser  Lys Met Gly Pro Gly  Asp Ile Ser Leu Pro  Gly Arg Pro 
    4730                 4735                 4740             


Lys Pro  Gly Pro Cys Ser Ser  Pro Gly Ser Ala Ser  Gln Ala Ser 
    4745                 4750                 4755             


Ser Ser  Gln Val Ser Ser Leu  Arg Val Gly Ser Ser  Gln Val Gly 
    4760                 4765                 4770             


Thr Glu  Pro Gly Pro Ser Leu  Asp Ala Glu Gly Trp  Thr Gln Glu 
    4775                 4780                 4785             


Ala Glu  Asp Leu Ser Asp Ser  Thr Pro Thr Leu Gln  Arg Pro Gln 
    4790                 4795                 4800             


Glu Gln  Ala Thr Met Arg Lys  Phe Ser Leu Gly Gly  Arg Gly Gly 
    4805                 4810                 4815             


Tyr Ala  Gly Val Ala Gly Tyr  Gly Thr Phe Ala Phe  Gly Gly Asp 
    4820                 4825                 4830             


Ala Gly  Gly Met Leu Gly Gln  Gly Pro Met Trp Ala  Arg Ile Ala 
    4835                 4840                 4845             


Trp Ala  Val Ser Gln Ser Glu  Glu Glu Glu Gln Glu  Glu Ala Arg 
    4850                 4855                 4860             


Ala Glu  Ser Gln Ser Glu Glu  Gln Gln Glu Ala Arg  Ala Glu Ser 
    4865                 4870                 4875             


Pro Leu  Pro Gln Val Ser Ala  Arg Pro Val Pro Glu  Val Gly Arg 
    4880                 4885                 4890             


Ala Pro  Thr Arg Ser Ser Pro  Glu Pro Thr Pro Trp  Glu Asp Ile 
    4895                 4900                 4905             


Gly Gln  Val Ser Leu Val Gln  Ile Arg Asp Leu Ser  Gly Asp Ala 
    4910                 4915                 4920             


Glu Ala  Ala Asp Thr Ile Ser  Leu Asp Ile Ser Glu  Val Asp Pro 
    4925                 4930                 4935             


Ala Tyr  Leu Asn Leu Ser Asp  Leu Tyr Asp Ile Lys  Tyr Leu Pro 
    4940                 4945                 4950             


Phe Glu  Phe Met Ile Phe Arg  Lys Val Pro Lys Ser  Ala Gln Pro 
    4955                 4960                 4965             


Glu Pro  Pro Ser Pro Met Ala  Glu Glu Glu Leu Ala  Glu Phe Pro 
    4970                 4975                 4980             


Glu Pro  Thr Trp Pro Trp Pro  Gly Glu Leu Gly Pro  His Ala Gly 
    4985                 4990                 4995             


Leu Glu  Ile Thr Glu Glu Ser  Glu Asp Val Asp Ala  Leu Leu Ala 
    5000                 5005                 5010             


Glu Ala  Ala Val Gly Arg Lys  Arg Lys Trp Ser Ser  Pro Ser Arg 
    5015                 5020                 5025             


Ser Leu  Phe His Phe Pro Gly  Arg His Leu Pro Leu  Asp Glu Pro 
    5030                 5035                 5040             


Ala Glu  Leu Gly Leu Arg Glu  Arg Val Lys Ala Ser  Val Glu His 
    5045                 5050                 5055             


Ile Ser  Arg Ile Leu Lys Gly  Arg Pro Glu Gly Leu  Glu Lys Glu 
    5060                 5065                 5070             


Gly Pro  Pro Arg Lys Lys Pro  Gly Leu Ala Ser Phe  Arg Leu Ser 
    5075                 5080                 5085             


Gly Leu  Lys Ser Trp Asp Arg  Ala Pro Thr Phe Leu  Arg Glu Leu 
    5090                 5095                 5100             


Ser Asp  Glu Thr Val Val Leu  Gly Gln Ser Val Thr  Leu Ala Cys 
    5105                 5110                 5115             


Gln Val  Ser Ala Gln Pro Ala  Ala Gln Ala Thr Trp  Ser Lys Asp 
    5120                 5125                 5130             


Gly Ala  Pro Leu Glu Ser Ser  Ser Arg Val Leu Ile  Ser Ala Thr 
    5135                 5140                 5145             


Leu Lys  Asn Phe Gln Leu Leu  Thr Ile Leu Val Val  Val Ala Glu 
    5150                 5155                 5160             


Asp Leu  Gly Val Tyr Thr Cys  Ser Val Ser Asn Ala  Leu Gly Thr 
    5165                 5170                 5175             


Val Thr  Thr Thr Gly Val Leu  Arg Lys Ala Glu Arg  Pro Ser Ser 
    5180                 5185                 5190             


Ser Pro  Cys Pro Asp Ile Gly  Glu Val Tyr Ala Asp  Gly Val Leu 
    5195                 5200                 5205             


Leu Val  Trp Lys Pro Val Glu  Ser Tyr Gly Pro Val  Thr Tyr Ile 
    5210                 5215                 5220             


Val Gln  Cys Ser Leu Glu Gly  Gly Ser Trp Thr Thr  Leu Ala Ser 
    5225                 5230                 5235             


Asp Ile  Phe Asp Cys Cys Tyr  Leu Thr Ser Lys Leu  Ser Arg Gly 
    5240                 5245                 5250             


Gly Thr  Tyr Thr Phe Arg Thr  Ala Cys Val Ser Lys  Ala Gly Met 
    5255                 5260                 5265             


Gly Pro  Tyr Ser Ser Pro Ser  Glu Gln Val Leu Leu  Gly Gly Pro 
    5270                 5275                 5280             


Ser His  Leu Ala Ser Glu Glu  Glu Ser Gln Gly Arg  Ser Ala Gln 
    5285                 5290                 5295             


Pro Leu  Pro Ser Thr Lys Thr  Phe Ala Phe Gln Thr  Gln Ile Gln 
    5300                 5305                 5310             


Arg Gly  Arg Phe Ser Val Val  Arg Gln Cys Trp Glu  Lys Ala Ser 
    5315                 5320                 5325             


Gly Arg  Ala Leu Ala Ala Lys  Ile Ile Pro Tyr His  Pro Lys Asp 
    5330                 5335                 5340             


Lys Thr  Ala Val Leu Arg Glu  Tyr Glu Ala Leu Lys  Gly Leu Arg 
    5345                 5350                 5355             


His Pro  His Leu Ala Gln Leu  His Ala Ala Tyr Leu  Ser Pro Arg 
    5360                 5365                 5370             


His Leu  Val Leu Ile Leu Glu  Leu Cys Ser Gly Pro  Glu Leu Leu 
    5375                 5380                 5385             


Pro Cys  Leu Ala Glu Arg Ala  Ser Tyr Ser Glu Ser  Glu Val Lys 
    5390                 5395                 5400             


Asp Tyr  Leu Trp Gln Met Leu  Ser Ala Thr Gln Tyr  Leu His Asn 
    5405                 5410                 5415             


Gln His  Ile Leu His Leu Asp  Leu Arg Ser Glu Asn  Met Ile Ile 
    5420                 5425                 5430             


Thr Glu  Tyr Asn Leu Leu Lys  Val Val Asp Leu Gly  Asn Ala Gln 
    5435                 5440                 5445             


Ser Leu  Ser Gln Glu Lys Val  Leu Pro Ser Asp Lys  Phe Lys Asp 
    5450                 5455                 5460             


Tyr Leu  Glu Thr Met Ala Pro  Glu Leu Leu Glu Gly  Gln Gly Ala 
    5465                 5470                 5475             


Val Pro  Gln Thr Asp Ile Trp  Ala Ile Gly Val Thr  Ala Phe Ile 
    5480                 5485                 5490             


Met Leu  Ser Ala Glu Tyr Pro  Val Ser Ser Glu Gly  Ala Arg Asp 
    5495                 5500                 5505             


Leu Gln  Arg Gly Leu Arg Lys  Gly Leu Val Arg Leu  Ser Arg Cys 
    5510                 5515                 5520             


Tyr Ala  Gly Leu Ser Gly Gly  Ala Val Ala Phe Leu  Arg Ser Thr 
    5525                 5530                 5535             


Leu Cys  Ala Gln Pro Trp Gly  Arg Pro Cys Ala Ser  Ser Cys Leu 
    5540                 5545                 5550             


Gln Cys  Pro Trp Leu Thr Glu  Glu Gly Pro Ala Cys  Ser Arg Pro 
    5555                 5560                 5565             


Ala Pro  Val Thr Phe Pro Thr  Ala Arg Leu Arg Val  Phe Val Arg 
    5570                 5575                 5580             


Asn Arg  Glu Lys Arg Arg Ala  Leu Leu Tyr Lys Arg  His Asn Leu 
    5585                 5590                 5595             


Ala Gln  Val Arg 
    5600         


<210> 6076
<211> 3739
<212> PRT
<213> Homo sapiens

<400> 6076
Met Leu Val Ile Arg Gly Ala Ser Leu Lys Asp Ala Gly Glu Tyr Thr 
1               5                   10                  15      


Cys Glu Val Glu Ala Ser Lys Ser Thr Ala Ser Leu His Val Glu Glu 
            20                  25                  30          


Lys Ala Asn Cys Phe Thr Glu Glu Leu Thr Asn Leu Gln Val Glu Glu 
        35                  40                  45              


Lys Gly Thr Ala Val Phe Thr Cys Lys Thr Glu His Pro Ala Ala Thr 
    50                  55                  60                  


Val Thr Trp Arg Lys Gly Leu Leu Glu Leu Arg Ala Ser Gly Lys His 
65                  70                  75                  80  


Gln Pro Ser Gln Glu Gly Leu Thr Leu Arg Leu Thr Ile Ser Ala Leu 
                85                  90                  95      


Glu Lys Ala Asp Ser Asp Thr Tyr Thr Cys Asp Ile Gly Gln Ala Gln 
            100                 105                 110         


Ser Arg Ala Gln Leu Leu Val Gln Gly Arg Arg Val His Ile Ile Glu 
        115                 120                 125             


Asp Leu Glu Asp Val Asp Val Gln Glu Gly Ser Ser Ala Thr Phe Arg 
    130                 135                 140                 


Cys Arg Ile Ser Pro Ala Asn Tyr Glu Pro Val His Trp Phe Leu Asp 
145                 150                 155                 160 


Lys Thr Pro Leu His Ala Asn Glu Leu Asn Glu Ile Asp Ala Gln Pro 
                165                 170                 175     


Gly Gly Tyr His Val Leu Thr Leu Arg Gln Leu Ala Leu Lys Asp Ser 
            180                 185                 190         


Gly Thr Ile Tyr Phe Glu Ala Gly Asp Gln Arg Ala Ser Ala Ala Leu 
        195                 200                 205             


Arg Val Thr Glu Lys Pro Ser Val Phe Ser Arg Glu Leu Thr Asp Ala 
    210                 215                 220                 


Thr Ile Thr Glu Gly Glu Asp Leu Thr Leu Val Cys Glu Thr Ser Thr 
225                 230                 235                 240 


Cys Asp Ile Pro Val Cys Trp Thr Lys Asp Gly Lys Thr Leu Arg Gly 
                245                 250                 255     


Ser Ala Arg Cys Gln Leu Ser His Glu Gly His Arg Ala Gln Leu Leu 
            260                 265                 270         


Ile Thr Gly Ala Thr Leu Gln Asp Ser Gly Arg Tyr Lys Cys Glu Ala 
        275                 280                 285             


Gly Gly Ala Cys Ser Ser Ser Ile Val Arg Val His Ala Arg Pro Val 
    290                 295                 300                 


Arg Phe Gln Glu Ala Leu Lys Asp Leu Glu Val Leu Glu Gly Gly Ala 
305                 310                 315                 320 


Ala Thr Leu Arg Cys Val Leu Ser Ser Val Ala Ala Pro Val Lys Trp 
                325                 330                 335     


Cys Tyr Gly Asn Asn Val Leu Arg Pro Gly Asp Lys Tyr Ser Leu Arg 
            340                 345                 350         


Gln Glu Gly Ala Met Leu Glu Leu Val Val Arg Asn Leu Arg Pro Gln 
        355                 360                 365             


Asp Ser Gly Arg Tyr Ser Cys Ser Phe Gly Asp Gln Thr Thr Ser Ala 
    370                 375                 380                 


Thr Leu Thr Val Thr Ala Leu Pro Ala Gln Phe Ile Gly Lys Leu Arg 
385                 390                 395                 400 


Asn Lys Glu Ala Thr Glu Gly Ala Thr Ala Thr Leu Arg Cys Glu Leu 
                405                 410                 415     


Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu Arg 
            420                 425                 430         


Asp Gly Asp Arg Tyr Cys Leu Arg Gln Asp Gly Ala Met Cys Glu Leu 
        435                 440                 445             


Gln Ile Arg Gly Leu Ala Met Val Asp Ala Ala Glu Tyr Ser Cys Val 
    450                 455                 460                 


Cys Gly Glu Glu Arg Thr Ser Ala Ser Leu Thr Ile Arg Pro Met Pro 
465                 470                 475                 480 


Ala His Phe Ile Gly Arg Leu Arg His Gln Glu Ser Ile Glu Gly Ala 
                485                 490                 495     


Thr Ala Thr Leu Arg Cys Glu Leu Ser Lys Ala Ala Pro Val Glu Trp 
            500                 505                 510         


Arg Lys Gly Arg Glu Ser Leu Arg Asp Gly Asp Arg His Ser Leu Arg 
        515                 520                 525             


Gln Asp Gly Ala Val Cys Glu Leu Gln Ile Cys Gly Leu Ala Val Ala 
    530                 535                 540                 


Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Glu Glu Arg Thr Ser Ala 
545                 550                 555                 560 


Thr Leu Thr Val Lys Ala Leu Pro Ala Lys Phe Thr Glu Gly Leu Arg 
                565                 570                 575     


Asn Glu Glu Ala Val Glu Gly Ala Thr Ala Met Leu Trp Cys Glu Leu 
            580                 585                 590         


Ser Lys Val Ala Pro Val Glu Trp Arg Lys Gly Pro Glu Asn Leu Arg 
        595                 600                 605             


Asp Gly Asp Arg Tyr Ile Leu Arg Gln Glu Gly Thr Arg Cys Glu Leu 
    610                 615                 620                 


Gln Ile Cys Gly Leu Ala Met Ala Asp Ala Gly Glu Tyr Leu Cys Val 
625                 630                 635                 640 


Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Ile Arg Ala Leu Pro 
                645                 650                 655     


Ala Arg Phe Ile Glu Asp Val Lys Asn Gln Glu Ala Arg Glu Gly Ala 
            660                 665                 670         


Thr Ala Val Leu Gln Cys Glu Leu Asn Ser Ala Ala Pro Val Glu Trp 
        675                 680                 685             


Arg Lys Gly Ser Glu Thr Leu Arg Asp Gly Asp Arg Tyr Ser Leu Arg 
    690                 695                 700                 


Gln Asp Gly Thr Lys Cys Glu Leu Gln Ile Arg Gly Leu Ala Met Ala 
705                 710                 715                 720 


Asp Thr Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser Ala 
                725                 730                 735     


Met Leu Thr Val Arg Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu Arg 
            740                 745                 750         


Asn Glu Glu Ala Thr Glu Gly Ala Thr Ala Val Leu Arg Cys Glu Leu 
        755                 760                 765             


Ser Lys Met Ala Pro Val Glu Trp Trp Lys Gly His Glu Thr Leu Arg 
    770                 775                 780                 


Asp Gly Asp Arg His Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu Leu 
785                 790                 795                 800 


Gln Ile Arg Gly Leu Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys Met 
                805                 810                 815     


Cys Gly Lys Glu Arg Thr Ser Ala Met Leu Thr Val Arg Ala Met Pro 
            820                 825                 830         


Ser Lys Phe Ile Glu Gly Leu Arg Asn Glu Glu Ala Thr Glu Gly Asp 
        835                 840                 845             


Thr Ala Thr Leu Trp Cys Glu Leu Ser Lys Ala Ala Pro Val Glu Trp 
    850                 855                 860                 


Arg Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His Ser Leu Arg 
865                 870                 875                 880 


Gln Asp Gly Ser Arg Cys Glu Leu Gln Ile Arg Gly Leu Ala Val Val 
                885                 890                 895     


Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser Ala 
            900                 905                 910         


Thr Leu Thr Val Arg Ala Leu Pro Ala Arg Phe Ile Glu Asp Val Lys 
        915                 920                 925             


Asn Gln Glu Ala Arg Glu Gly Ala Thr Ala Val Leu Gln Cys Glu Leu 
    930                 935                 940                 


Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu Arg 
945                 950                 955                 960 


Gly Gly Asp Arg Tyr Ser Leu Arg Gln Asp Gly Thr Arg Cys Glu Leu 
                965                 970                 975     


Gln Ile His Gly Leu Ser Val Ala Asp Thr Gly Glu Tyr Ser Cys Val 
            980                 985                 990         


Cys Gly Gln Glu Arg Thr Ser Ala  Thr Leu Thr Val Arg  Ala Pro Gln 
        995                 1000                 1005             


Pro Val  Phe Arg Glu Pro Leu  Gln Ser Leu Gln Ala  Glu Glu Gly 
    1010                 1015                 1020             


Ser Thr  Ala Thr Leu Gln Cys  Glu Leu Ser Glu Pro  Thr Ala Thr 
    1025                 1030                 1035             


Val Val  Trp Ser Lys Gly Gly  Leu Gln Leu Gln Ala  Asn Gly Arg 
    1040                 1045                 1050             


Arg Glu  Pro Arg Leu Gln Gly  Cys Thr Ala Glu Leu  Val Leu Gln 
    1055                 1060                 1065             


Asp Leu  Gln Arg Glu Asp Thr  Gly Glu Tyr Thr Cys  Thr Cys Gly 
    1070                 1075                 1080             


Ser Gln  Ala Thr Ser Ala Thr  Leu Thr Val Thr Ala  Ala Pro Val 
    1085                 1090                 1095             


Arg Phe  Leu Arg Glu Leu Gln  His Gln Glu Val Asp  Glu Gly Gly 
    1100                 1105                 1110             


Thr Ala  His Leu Cys Cys Glu  Leu Ser Arg Ala Gly  Ala Ser Val 
    1115                 1120                 1125             


Glu Trp  Arg Lys Gly Ser Leu  Gln Leu Phe Pro Cys  Ala Lys Tyr 
    1130                 1135                 1140             


Gln Met  Val Gln Asp Gly Ala  Ala Ala Glu Leu Leu  Val Arg Gly 
    1145                 1150                 1155             


Val Glu  Gln Glu Asp Ala Gly  Asp Tyr Thr Cys Asp  Thr Gly His 
    1160                 1165                 1170             


Thr Gln  Ser Met Ala Ser Leu  Ser Val Arg Val Pro  Arg Pro Lys 
    1175                 1180                 1185             


Phe Lys  Thr Arg Leu Gln Ser  Leu Glu Gln Glu Thr  Gly Asp Ile 
    1190                 1195                 1200             


Ala Arg  Leu Cys Cys Gln Leu  Ser Asp Ala Glu Ser  Gly Ala Val 
    1205                 1210                 1215             


Val Gln  Trp Leu Lys Glu Gly  Val Glu Leu His Ala  Gly Pro Lys 
    1220                 1225                 1230             


Tyr Glu  Met Arg Ser Gln Gly  Ala Thr Arg Glu Leu  Leu Ile His 
    1235                 1240                 1245             


Gln Leu  Glu Ala Lys Asp Thr  Gly Glu Tyr Ala Cys  Val Thr Gly 
    1250                 1255                 1260             


Gly Gln  Lys Thr Ala Ala Ser  Leu Arg Val Thr Glu  Pro Glu Val 
    1265                 1270                 1275             


Thr Ile  Val Arg Gly Leu Val  Asp Ala Glu Val Thr  Ala Asp Glu 
    1280                 1285                 1290             


Asp Val  Glu Phe Ser Cys Glu  Val Ser Arg Ala Gly  Ala Thr Gly 
    1295                 1300                 1305             


Val Gln  Trp Cys Leu Gln Gly  Leu Pro Leu Gln Ser  Asn Glu Val 
    1310                 1315                 1320             


Thr Glu  Val Ala Val Arg Asp  Gly Arg Ile His Thr  Leu Arg Leu 
    1325                 1330                 1335             


Lys Gly  Val Thr Pro Glu Asp  Ala Gly Thr Val Ser  Phe His Leu 
    1340                 1345                 1350             


Gly Asn  His Ala Ser Ser Ala  Gln Leu Thr Val Arg  Ala Pro Glu 
    1355                 1360                 1365             


Val Thr  Ile Leu Glu Pro Leu  Gln Asp Val Gln Leu  Ser Glu Gly 
    1370                 1375                 1380             


Gln Asp  Ala Ser Phe Gln Cys  Arg Leu Ser Arg Ala  Ser Gly Gln 
    1385                 1390                 1395             


Glu Ala  Arg Trp Ala Leu Gly  Gly Val Pro Leu Gln  Ala Asn Glu 
    1400                 1405                 1410             


Met Asn  Asp Ile Thr Val Glu  Gln Gly Thr Leu His  Leu Leu Thr 
    1415                 1420                 1425             


Leu His  Lys Val Thr Leu Glu  Asp Ala Gly Thr Val  Ser Phe His 
    1430                 1435                 1440             


Val Gly  Thr Cys Ser Ser Glu  Ala Gln Leu Lys Val  Thr Ala Lys 
    1445                 1450                 1455             


Asn Thr  Val Val Arg Gly Leu  Glu Asn Val Glu Ala  Leu Glu Gly 
    1460                 1465                 1470             


Gly Glu  Ala Leu Phe Glu Cys  Gln Leu Ser Gln Pro  Glu Val Ala 
    1475                 1480                 1485             


Ala His  Thr Trp Leu Leu Asp  Asp Glu Pro Val His  Thr Ser Glu 
    1490                 1495                 1500             


Asn Ala  Glu Val Val Phe Phe  Glu Asn Gly Leu Arg  His Leu Leu 
    1505                 1510                 1515             


Leu Leu  Lys Asn Leu Arg Pro  Gln Asp Ser Cys Arg  Val Thr Phe 
    1520                 1525                 1530             


Leu Ala  Gly Asp Met Val Thr  Ser Ala Phe Leu Thr  Val Arg Gly 
    1535                 1540                 1545             


Trp Arg  Leu Glu Ile Leu Glu  Pro Leu Lys Asn Ala  Ala Val Arg 
    1550                 1555                 1560             


Ala Gly  Ala Gln Ala Cys Phe  Thr Cys Thr Leu Ser  Glu Ala Val 
    1565                 1570                 1575             


Pro Val  Gly Glu Ala Ser Trp  Tyr Ile Asn Gly Ala  Ala Val Gln 
    1580                 1585                 1590             


Pro Asp  Asp Ser Asp Trp Thr  Val Thr Ala Asp Gly  Ser His His 
    1595                 1600                 1605             


Ala Leu  Leu Leu Arg Ser Ala  Gln Pro His His Ala  Gly Glu Val 
    1610                 1615                 1620             


Thr Phe  Ala Cys Arg Asp Ala  Val Ala Ser Ala Arg  Leu Thr Val 
    1625                 1630                 1635             


Leu Gly  Leu Pro Asp Pro Pro  Glu Asp Ala Glu Val  Val Ala Arg 
    1640                 1645                 1650             


Ser Ser  His Thr Val Thr Leu  Ser Trp Ala Ala Pro  Met Ser Asp 
    1655                 1660                 1665             


Gly Gly  Gly Gly Leu Cys Gly  Tyr Arg Val Glu Val  Lys Glu Gly 
    1670                 1675                 1680             


Ala Thr  Gly Gln Trp Arg Leu  Cys His Glu Leu Val  Pro Gly Pro 
    1685                 1690                 1695             


Glu Cys  Val Val Asp Gly Leu  Ala Pro Gly Glu Thr  Tyr Arg Phe 
    1700                 1705                 1710             


Arg Val  Ala Ala Val Gly Pro  Val Gly Ala Gly Glu  Pro Val His 
    1715                 1720                 1725             


Leu Pro  Gln Thr Val Arg Leu  Ala Glu Pro Pro Lys  Pro Val Pro 
    1730                 1735                 1740             


Pro Gln  Pro Ser Ala Pro Glu  Ser Arg Gln Val Ala  Ala Gly Glu 
    1745                 1750                 1755             


Asp Val  Ser Leu Glu Leu Glu  Val Val Ala Glu Ala  Gly Glu Val 
    1760                 1765                 1770             


Ile Trp  His Lys Gly Met Glu  Arg Ile Gln Pro Gly  Gly Arg Phe 
    1775                 1780                 1785             


Glu Val  Val Ser Gln Gly Arg  Gln Gln Met Leu Val  Ile Lys Gly 
    1790                 1795                 1800             


Phe Thr  Ala Glu Asp Gln Gly  Glu Tyr His Cys Gly  Leu Ala Gln 
    1805                 1810                 1815             


Gly Ser  Ile Cys Pro Ala Ala  Ala Thr Phe Gln Val  Ala Leu Ser 
    1820                 1825                 1830             


Pro Ala  Ser Val Asp Glu Ala  Pro Gln Pro Ser Leu  Pro Pro Glu 
    1835                 1840                 1845             


Ala Ala  Gln Glu Gly Asp Leu  His Leu Leu Trp Glu  Ala Leu Ala 
    1850                 1855                 1860             


Arg Lys  Arg Arg Met Ser Arg  Glu Pro Thr Leu Asp  Ser Ile Ser 
    1865                 1870                 1875             


Glu Leu  Pro Glu Glu Asp Gly  Arg Ser Gln Arg Leu  Pro Gln Glu 
    1880                 1885                 1890             


Ala Glu  Glu Val Ala Pro Asp  Leu Ser Glu Gly Tyr  Ser Thr Ala 
    1895                 1900                 1905             


Asp Glu  Leu Ala Arg Thr Gly  Asp Ala Asp Leu Ser  His Thr Ser 
    1910                 1915                 1920             


Ser Asp  Asp Glu Ser Arg Ala  Gly Thr Pro Ser Leu  Val Thr Tyr 
    1925                 1930                 1935             


Leu Lys  Lys Ala Gly Arg Pro  Gly Thr Ser Pro Leu  Ala Ser Lys 
    1940                 1945                 1950             


Val Gly  Ala Pro Ala Ala Pro  Ser Val Lys Pro Gln  Gln Gln Gln 
    1955                 1960                 1965             


Glu Pro  Leu Ala Ala Val Arg  Pro Pro Leu Gly Asp  Leu Ser Thr 
    1970                 1975                 1980             


Lys Asp  Leu Gly Asp Pro Ser  Met Asp Lys Ala Ala  Val Lys Ile 
    1985                 1990                 1995             


Gln Ala  Ala Phe Lys Gly Tyr  Lys Val Arg Lys Glu  Met Lys Gln 
    2000                 2005                 2010             


Gln Glu  Gly Pro Met Phe Ser  His Thr Phe Gly Asp  Thr Glu Ala 
    2015                 2020                 2025             


Gln Val  Gly Asp Ala Leu Arg  Leu Glu Cys Val Val  Ala Ser Lys 
    2030                 2035                 2040             


Ala Asp  Val Arg Ala Arg Trp  Leu Lys Asp Gly Val  Glu Leu Thr 
    2045                 2050                 2055             


Asp Gly  Arg His His His Ile  Asp Gln Leu Gly Asp  Gly Thr Cys 
    2060                 2065                 2070             


Ser Leu  Leu Ile Thr Gly Leu  Asp Arg Ala Asp Ala  Gly Cys Tyr 
    2075                 2080                 2085             


Thr Cys  Gln Val Ser Asn Lys  Phe Gly Gln Val Thr  His Ser Ala 
    2090                 2095                 2100             


Cys Val  Val Val Ser Gly Ser  Glu Ser Glu Ala Glu  Ser Ser Ser 
    2105                 2110                 2115             


Gly Gly  Glu Leu Asp Asp Ala  Phe Arg Arg Ala Ala  Arg Arg Leu 
    2120                 2125                 2130             


His Arg  Leu Phe Arg Thr Lys  Ser Pro Ala Glu Val  Ser Asp Glu 
    2135                 2140                 2145             


Glu Leu  Phe Leu Ser Ala Asp  Glu Gly Pro Ala Glu  Pro Glu Glu 
    2150                 2155                 2160             


Pro Ala  Asp Trp Gln Thr Tyr  Arg Glu Asp Glu His  Phe Ile Cys 
    2165                 2170                 2175             


Ile Arg  Phe Glu Ala Leu Thr  Glu Ala Arg Gln Ala  Val Thr Arg 
    2180                 2185                 2190             


Phe Gln  Glu Met Phe Ala Thr  Leu Gly Ile Gly Val  Glu Ile Lys 
    2195                 2200                 2205             


Leu Val  Glu Gln Gly Pro Arg  Arg Val Glu Met Cys  Ile Ser Lys 
    2210                 2215                 2220             


Glu Thr  Pro Ala Pro Val Val  Pro Pro Glu Pro Leu  Pro Ser Leu 
    2225                 2230                 2235             


Leu Thr  Ser Asp Ala Ala Pro  Val Phe Leu Thr Glu  Leu Gln Asn 
    2240                 2245                 2250             


Gln Glu  Val Gln Asp Gly Tyr  Pro Val Ser Phe Asp  Cys Val Val 
    2255                 2260                 2265             


Thr Gly  Gln Pro Met Pro Ser  Val Arg Trp Phe Lys  Asp Gly Lys 
    2270                 2275                 2280             


Leu Leu  Glu Glu Asp Asp His  Tyr Met Ile Asn Glu  Asp Gln Gln 
    2285                 2290                 2295             


Gly Gly  His Gln Leu Ile Ile  Thr Ala Val Val Pro  Ala Asp Met 
    2300                 2305                 2310             


Gly Val  Tyr Arg Cys Leu Ala  Glu Asn Ser Met Gly  Val Ser Ser 
    2315                 2320                 2325             


Thr Lys  Ala Glu Leu Arg Val  Asp Leu Thr Ser Thr  Asp Tyr Asp 
    2330                 2335                 2340             


Thr Ala  Ala Asp Ala Thr Glu  Ser Ser Ser Tyr Phe  Ser Ala Gln 
    2345                 2350                 2355             


Gly Tyr  Leu Ser Ser Arg Glu  Gln Glu Gly Thr Glu  Ser Thr Thr 
    2360                 2365                 2370             


Asp Glu  Gly Gln Leu Pro Gln  Val Val Glu Glu Leu  Arg Asp Leu 
    2375                 2380                 2385             


Gln Val  Ala Pro Gly Thr Arg  Leu Ala Lys Phe Gln  Leu Lys Val 
    2390                 2395                 2400             


Lys Gly  Tyr Pro Ala Pro Arg  Leu Tyr Trp Phe Lys  Asp Gly Gln 
    2405                 2410                 2415             


Pro Leu  Thr Ala Ser Ala His  Ile Arg Met Thr Asp  Lys Lys Ile 
    2420                 2425                 2430             


Leu His  Thr Leu Glu Ile Ile  Ser Val Thr Arg Glu  Asp Ser Gly 
    2435                 2440                 2445             


Gln Tyr  Ala Ala Tyr Ile Ser  Asn Ala Met Gly Ala  Ala Tyr Ser 
    2450                 2455                 2460             


Ser Ala  Arg Leu Leu Val Arg  Gly Pro Asp Glu Pro  Glu Glu Lys 
    2465                 2470                 2475             


Pro Ala  Ser Asp Val His Glu  Gln Leu Val Pro Pro  Arg Met Leu 
    2480                 2485                 2490             


Glu Arg  Phe Thr Pro Lys Lys  Val Lys Lys Gly Ser  Ser Ile Thr 
    2495                 2500                 2505             


Phe Ser  Val Lys Val Glu Gly  Arg Pro Val Pro Thr  Val His Trp 
    2510                 2515                 2520             


Leu Arg  Glu Glu Ala Glu Arg  Gly Val Leu Trp Ile  Gly Pro Asp 
    2525                 2530                 2535             


Thr Pro  Gly Tyr Thr Val Ala  Ser Ser Ala Gln Gln  His Ser Leu 
    2540                 2545                 2550             


Val Leu  Leu Asp Val Gly Arg  Gln His Gln Gly Thr  Tyr Thr Cys 
    2555                 2560                 2565             


Ile Ala  Ser Asn Ala Ala Gly  Gln Ala Leu Cys Ser  Ala Ser Leu 
    2570                 2575                 2580             


His Val  Ser Gly Leu Pro Lys  Val Glu Glu Gln Glu  Lys Val Lys 
    2585                 2590                 2595             


Glu Ala  Leu Ile Ser Thr Phe  Leu Gln Gly Thr Thr  Gln Ala Ile 
    2600                 2605                 2610             


Ser Ala  Gln Gly Leu Glu Thr  Ala Ser Phe Ala Asp  Leu Gly Gly 
    2615                 2620                 2625             


Gln Arg  Lys Glu Glu Pro Leu  Ala Ala Lys Glu Ala  Leu Gly His 
    2630                 2635                 2640             


Leu Ser  Leu Ala Glu Val Gly  Thr Glu Glu Phe Leu  Gln Lys Leu 
    2645                 2650                 2655             


Thr Ser  Gln Ile Thr Glu Met  Val Ser Ala Lys Ile  Thr Gln Ala 
    2660                 2665                 2670             


Lys Leu  Gln Val Pro Gly Gly  Asp Ser Asp Glu Asp  Ser Lys Thr 
    2675                 2680                 2685             


Pro Ser  Ala Ser Pro Arg His  Gly Arg Ser Arg Pro  Ser Ser Ser 
    2690                 2695                 2700             


Ile Gln  Glu Ser Ser Ser Glu  Ser Glu Asp Gly Asp  Ala Arg Gly 
    2705                 2710                 2715             


Glu Ile  Phe Asp Ile Tyr Val  Val Thr Ala Asp Tyr  Leu Pro Leu 
    2720                 2725                 2730             


Gly Ala  Glu Gln Asp Ala Ile  Thr Leu Arg Glu Gly  Gln Tyr Val 
    2735                 2740                 2745             


Glu Val  Leu Asp Ala Ala His  Pro Leu Arg Trp Leu  Val Arg Thr 
    2750                 2755                 2760             


Lys Pro  Thr Lys Ser Ser Pro  Ser Arg Gln Gly Trp  Val Ser Pro 
    2765                 2770                 2775             


Ala Tyr  Leu Asp Arg Arg Leu  Lys Leu Ser Pro Glu  Trp Gly Ala 
    2780                 2785                 2790             


Ala Glu  Ala Pro Glu Phe Pro  Gly Glu Ala Val Ser  Glu Asp Glu 
    2795                 2800                 2805             


Tyr Lys  Ala Arg Leu Ser Ser  Val Ile Gln Glu Leu  Leu Ser Ser 
    2810                 2815                 2820             


Glu Gln  Ala Phe Val Glu Glu  Leu Gln Phe Leu Gln  Ser His His 
    2825                 2830                 2835             


Leu Gln  His Leu Glu Arg Cys  Pro His Val Pro Ile  Ala Val Ala 
    2840                 2845                 2850             


Gly Gln  Lys Ala Val Ile Phe  Arg Asn Val Arg Asp  Ile Gly Arg 
    2855                 2860                 2865             


Phe His  Ser Ser Phe Leu Gln  Glu Leu Gln Gln Cys  Asp Thr Asp 
    2870                 2875                 2880             


Asp Asp  Val Ala Met Cys Phe  Ile Lys Asn Gln Ala  Ala Phe Glu 
    2885                 2890                 2895             


Gln Tyr  Leu Glu Phe Leu Val  Gly Arg Val Gln Ala  Glu Ser Val 
    2900                 2905                 2910             


Val Val  Ser Thr Ala Ile Gln  Glu Phe Tyr Lys Lys  Tyr Ala Glu 
    2915                 2920                 2925             


Glu Ala  Leu Leu Ala Gly Asp  Pro Ser Gln Pro Pro  Pro Pro Pro 
    2930                 2935                 2940             


Leu Gln  His Tyr Leu Glu Gln  Pro Val Glu Arg Val  Gln Arg Tyr 
    2945                 2950                 2955             


Gln Ala  Leu Leu Lys Glu Leu  Ile Arg Asn Lys Ala  Arg Asn Arg 
    2960                 2965                 2970             


Gln Asn  Cys Ala Leu Leu Glu  Gln Ala Tyr Ala Val  Val Ser Ala 
    2975                 2980                 2985             


Leu Pro  Gln Arg Ala Glu Asn  Lys Leu His Val Ser  Leu Met Glu 
    2990                 2995                 3000             


Asn Tyr  Pro Gly Thr Leu Gln  Ala Leu Gly Glu Pro  Ile Arg Gln 
    3005                 3010                 3015             


Gly His  Phe Ile Val Trp Glu  Gly Ala Pro Gly Ala  Arg Met Pro 
    3020                 3025                 3030             


Trp Lys  Gly His Asn Arg His  Val Phe Leu Phe Arg  Asn His Leu 
    3035                 3040                 3045             


Val Ile  Cys Lys Pro Arg Arg  Asp Ser Arg Thr Asp  Thr Val Ser 
    3050                 3055                 3060             


Tyr Val  Phe Arg Asn Met Met  Lys Leu Ser Ser Ile  Asp Leu Asn 
    3065                 3070                 3075             


Asp Gln  Val Glu Gly Asp Asp  Arg Ala Phe Glu Val  Trp Gln Glu 
    3080                 3085                 3090             


Arg Glu  Asp Ser Val Arg Lys  Tyr Leu Leu Gln Ala  Arg Thr Ala 
    3095                 3100                 3105             


Ile Ile  Lys Ser Ser Trp Val  Lys Glu Ile Cys Gly  Ile Gln Gln 
    3110                 3115                 3120             


Arg Leu  Ala Leu Pro Val Trp  Arg Pro Pro Asp Phe  Glu Glu Glu 
    3125                 3130                 3135             


Leu Ala  Asp Cys Thr Ala Glu  Leu Gly Glu Thr Val  Lys Leu Ala 
    3140                 3145                 3150             


Cys Arg  Val Thr Gly Thr Pro  Lys Pro Val Ile Ser  Trp Tyr Lys 
    3155                 3160                 3165             


Asp Gly  Lys Ala Val Gln Val  Asp Pro His His Ile  Leu Ile Glu 
    3170                 3175                 3180             


Asp Pro  Asp Gly Ser Cys Ala  Leu Ile Leu Asp Ser  Leu Thr Gly 
    3185                 3190                 3195             


Val Asp  Ser Gly Gln Tyr Met  Cys Phe Ala Ala Ser  Ala Ala Gly 
    3200                 3205                 3210             


Asn Cys  Ser Thr Leu Gly Lys  Ile Leu Val Gln Val  Pro Pro Arg 
    3215                 3220                 3225             


Phe Val  Asn Lys Val Arg Ala  Ser Pro Phe Val Glu  Gly Glu Asp 
    3230                 3235                 3240             


Ala Gln  Phe Thr Cys Thr Ile  Glu Gly Ala Pro Tyr  Pro Gln Ile 
    3245                 3250                 3255             


Arg Trp  Tyr Lys Asp Gly Ala  Leu Leu Thr Thr Gly  Asn Lys Phe 
    3260                 3265                 3270             


Gln Thr  Leu Ser Glu Pro Arg  Ser Gly Leu Leu Val  Leu Val Ile 
    3275                 3280                 3285             


Arg Ala  Ala Ser Lys Glu Asp  Leu Gly Leu Tyr Glu  Cys Glu Leu 
    3290                 3295                 3300             


Val Asn  Arg Leu Gly Ser Ala  Arg Ala Ser Ala Glu  Leu Arg Ile 
    3305                 3310                 3315             


Gln Ser  Pro Met Leu Gln Ala  Gln Glu Gln Cys His  Arg Glu Gln 
    3320                 3325                 3330             


Leu Val  Ala Ala Val Glu Val  Thr Glu Gln Glu Thr  Lys Val Pro 
    3335                 3340                 3345             


Lys Lys  Thr Val Ile Ile Glu  Glu Thr Ile Thr Thr  Val Val Lys 
    3350                 3355                 3360             


Ser Pro  Arg Gly Gln Arg Arg  Ser Pro Ser Lys Ser  Pro Ser Arg 
    3365                 3370                 3375             


Ser Pro  Ser Arg Cys Ser Ala  Ser Pro Leu Arg Pro  Gly Leu Leu 
    3380                 3385                 3390             


Ala Pro  Asp Leu Leu Tyr Leu  Pro Gly Ala Gly Gln  Pro Arg Arg 
    3395                 3400                 3405             


Pro Glu  Ala Glu Pro Gly Gln  Lys Pro Val Val Pro  Thr Leu Tyr 
    3410                 3415                 3420             


Val Thr  Glu Ala Glu Ala His  Ser Pro Ala Leu Pro  Gly Leu Ser 
    3425                 3430                 3435             


Gly Pro  Gln Pro Lys Trp Val  Glu Val Glu Glu Thr  Ile Glu Val 
    3440                 3445                 3450             


Arg Val  Lys Lys Met Gly Pro  Gln Gly Val Ser Pro  Thr Thr Glu 
    3455                 3460                 3465             


Val Pro  Arg Ser Ser Ser Gly  His Leu Phe Thr Leu  Pro Gly Ala 
    3470                 3475                 3480             


Thr Pro  Gly Gly Asp Pro Asn  Ser Asn Asn Ser Asn  Asn Lys Leu 
    3485                 3490                 3495             


Leu Ala  Gln Glu Ala Trp Ala  Gln Gly Thr Ala Met  Val Gly Val 
    3500                 3505                 3510             


Arg Glu  Pro Leu Val Phe Arg  Val Asp Ala Arg Gly  Ser Val Asp 
    3515                 3520                 3525             


Trp Ala  Ala Ser Gly Met Gly  Ser Leu Glu Glu Glu  Gly Thr Met 
    3530                 3535                 3540             


Glu Glu  Ala Gly Glu Glu Glu  Gly Glu Asp Gly Asp  Ala Phe Val 
    3545                 3550                 3555             


Thr Glu  Glu Ser Gln Asp Thr  His Ser Leu Gly Asp  Arg Asp Pro 
    3560                 3565                 3570             


Lys Ile  Leu Thr His Asn Gly  Arg Met Leu Thr Leu  Ala Asp Leu 
    3575                 3580                 3585             


Glu Asp  Tyr Val Pro Gly Glu  Gly Glu Thr Phe His  Cys Gly Gly 
    3590                 3595                 3600             


Pro Gly  Pro Gly Ala Pro Asp  Asp Pro Pro Cys Glu  Val Ser Val 
    3605                 3610                 3615             


Ile Gln  Arg Glu Ile Gly Glu  Pro Thr Val Gly Gln  Pro Val Leu 
    3620                 3625                 3630             


Leu Ser  Val Gly His Ala Leu  Gly Pro Arg Gly Pro  Leu Gly Leu 
    3635                 3640                 3645             


Phe Arg  Pro Glu Pro Arg Gly  Ala Ser Pro Pro Gly  Pro Gln Val 
    3650                 3655                 3660             


Arg Ser  Leu Glu Gly Thr Ser  Phe Leu Leu Arg Glu  Ala Pro Ala 
    3665                 3670                 3675             


Arg Pro  Val Gly Ser Ala Pro  Trp Thr Gln Ser Phe  Cys Thr Arg 
    3680                 3685                 3690             


Ile Arg  Arg Ser Ala Asp Ser  Gly Gln Ser Ser Phe  Thr Thr Glu 
    3695                 3700                 3705             


Leu Ser  Thr Gln Thr Val Asn  Phe Gly Thr Val Gly  Glu Thr Val 
    3710                 3715                 3720             


Thr Leu  His Ile Cys Pro Asp  Arg Asp Gly Asp Glu  Ala Ala Gln 
    3725                 3730                 3735             


Pro 
    


<210> 6077
<211> 356
<212> PRT
<213> Homo sapiens

<400> 6077
Met Ala Thr Ala Ala Leu Leu Arg Gly Ala Thr Pro Gly Arg Gly Gly 
1               5                   10                  15      


Pro Val Trp Arg Trp Arg Leu Arg Ala Ala Pro Arg Cys Arg Leu Ala 
            20                  25                  30          


His Ser Ser Cys Ser Pro Gly Gly Asp Pro Thr Ala Gly Ala Ala Trp 
        35                  40                  45              


Ala Cys Phe Arg Leu Asp Gly Arg Thr Leu Leu Arg Val Arg Gly Pro 
    50                  55                  60                  


Asp Ala Ala Pro Phe Leu Leu Gly Leu Leu Thr Asn Glu Leu Pro Leu 
65                  70                  75                  80  


Pro Ser Pro Ala Ala Ala Gly Ala Pro Pro Ala Ala Arg Ala Gly Tyr 
                85                  90                  95      


Ala His Phe Leu Asn Val Gln Gly Arg Thr Leu Tyr Asp Val Ile Leu 
            100                 105                 110         


Tyr Gly Leu Gln Glu His Ser Glu Val Ser Gly Phe Leu Leu Glu Cys 
        115                 120                 125             


Asp Ser Ser Val Gln Gly Ala Leu Gln Lys His Leu Ala Leu Tyr Arg 
    130                 135                 140                 


Ile Arg Arg Lys Val Thr Val Glu Pro His Pro Glu Leu Arg Val Trp 
145                 150                 155                 160 


Ala Val Leu Pro Ser Ser Pro Glu Ala Cys Gly Ala Ala Ser Leu Gln 
                165                 170                 175     


Glu Arg Ala Gly Ala Ala Ala Ile Leu Ile Arg Asp Pro Arg Thr Ala 
            180                 185                 190         


Arg Met Gly Trp Arg Leu Leu Thr Gln Asp Glu Gly Pro Ala Leu Val 
        195                 200                 205             


Pro Gly Gly Arg Leu Gly Asp Leu Trp Asp Tyr His Gln His Arg Tyr 
    210                 215                 220                 


Leu Gln Gly Val Pro Glu Gly Val Arg Asp Leu Pro Pro Gly Val Ala 
225                 230                 235                 240 


Leu Pro Leu Glu Ser Asn Leu Ala Phe Met Asn Gly Val Ser Phe Thr 
                245                 250                 255     


Lys Gly Cys Tyr Ile Gly Gln Glu Leu Thr Ala Arg Thr His His Met 
            260                 265                 270         


Gly Val Ile Arg Lys Arg Leu Phe Pro Val Arg Phe Leu Asp Pro Leu 
        275                 280                 285             


Pro Thr Ser Gly Ile Thr Pro Gly Ala Thr Val Leu Thr Ala Ser Gly 
    290                 295                 300                 


Gln Thr Val Gly Lys Phe Arg Ala Gly Gln Gly Asn Val Gly Leu Ala 
305                 310                 315                 320 


Leu Leu Trp Ser Glu Lys Ile Lys Gly Pro Leu His Ile Arg Ala Ser 
                325                 330                 335     


Glu Gly Ala Gln Val Ala Leu Ala Ala Ser Val Pro Asp Trp Trp Pro 
            340                 345                 350         


Thr Val Ser Lys 
        355     


<210> 6078
<211> 464
<212> PRT
<213> Homo sapiens

<400> 6078
Met Arg Ala Ala Arg Arg Gly Leu His Cys Ala Gly Ala Glu Arg Pro 
1               5                   10                  15      


Arg Arg Arg Gly Arg Leu Trp Asp Ser Ser Gly Val Pro Gln Arg Gln 
            20                  25                  30          


Lys Arg Pro Gly Pro Trp Arg Thr Gln Thr Gln Glu Gln Met Ser Arg 
        35                  40                  45              


Asp Val Cys Ile His Thr Trp Pro Cys Thr Tyr Tyr Leu Glu Pro Lys 
    50                  55                  60                  


Arg Arg Trp Val Thr Gly Gln Leu Ser Leu Thr Ser Leu Ser Leu Arg 
65                  70                  75                  80  


Phe Met Thr Asp Ser Thr Gly Glu Ile Leu Val Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Ile Val Glu Ile Lys Lys Glu Ala Ser His Phe Ile Phe Ser Ser 
            100                 105                 110         


Ile Thr Ile Leu Glu Lys Gly His Ala Lys His Trp Phe Ser Ser Leu 
        115                 120                 125             


Arg Pro Ser Arg Asn Val Val Phe Ser Ile Ile Glu His Phe Trp Arg 
    130                 135                 140                 


Glu Leu Leu Leu Ser Gln Pro Gly Ala Val Ala Asp Ala Ser Val Pro 
145                 150                 155                 160 


Arg Thr Arg Gly Glu Glu Leu Thr Gly Leu Met Ala Gly Ser Gln Lys 
                165                 170                 175     


Arg Leu Glu Asp Thr Ala Arg Val Leu His His Gln Gly Gln Gln Leu 
            180                 185                 190         


Asp Ser Val Met Arg Gly Leu Asp Lys Met Glu Ser Asp Leu Glu Val 
        195                 200                 205             


Ala Asp Arg Leu Leu Thr Glu Leu Glu Ser Pro Ala Trp Trp Pro Phe 
    210                 215                 220                 


Ser Ser Lys Leu Trp Lys Thr Pro Pro Glu Thr Lys Pro Arg Glu Asp 
225                 230                 235                 240 


Val Ser Met Thr Ser Cys Glu Pro Phe Gly Lys Glu Gly Ile Leu Ile 
                245                 250                 255     


Lys Ile Pro Ala Val Ile Ser His Arg Thr Glu Ser His Val Lys Pro 
            260                 265                 270         


Gly Arg Leu Thr Val Leu Val Ser Gly Leu Glu Ile His Asp Ser Ser 
        275                 280                 285             


Ser Leu Leu Met His Arg Phe Glu Arg Glu Asp Val Asp Asp Ile Lys 
    290                 295                 300                 


Val His Ser Pro Tyr Glu Ile Ser Ile Arg Gln Arg Phe Ile Gly Lys 
305                 310                 315                 320 


Pro Asp Met Ala Tyr Arg Leu Ile Ser Ala Lys Met Pro Glu Val Ile 
                325                 330                 335     


Pro Ile Leu Glu Val Gln Phe Ser Lys Lys Met Glu Leu Leu Glu Asp 
            340                 345                 350         


Ala Leu Val Leu Arg Ser Ala Arg Thr Ser Ser Pro Ala Glu Lys Ser 
        355                 360                 365             


Cys Ser Val Trp His Ala Ala Ser Gly Leu Met Gly Arg Thr Leu His 
    370                 375                 380                 


Arg Glu Pro Pro Ala Gly Asp Gln Glu Gly Thr Ala Leu His Leu Gln 
385                 390                 395                 400 


Thr Ser Leu Pro Ala Leu Ser Glu Ala Asp Thr Gln Glu Leu Thr Gln 
                405                 410                 415     


Ile Leu Arg Arg Met Lys Gly Leu Ala Leu Glu Ala Glu Ser Glu Leu 
            420                 425                 430         


Glu Arg Gln Asp Glu Ala Leu Asp Gly Val Ala Ala Ala Val Asp Arg 
        435                 440                 445             


Ala Thr Leu Thr Ile Asp Lys His Asn Arg Arg Met Lys Arg Leu Thr 
    450                 455                 460                 


<210> 6079
<211> 222
<212> PRT
<213> Homo sapiens

<400> 6079
Met Thr Ser Cys Glu Pro Phe Gly Lys Glu Gly Ile Leu Ile Lys Ile 
1               5                   10                  15      


Pro Ala Val Ile Ser His Arg Thr Glu Ser His Val Lys Pro Gly Arg 
            20                  25                  30          


Leu Thr Val Leu Val Ser Gly Leu Glu Ile His Asp Ser Ser Ser Leu 
        35                  40                  45              


Leu Met His Arg Phe Glu Arg Glu Asp Val Asp Asp Ile Lys Val His 
    50                  55                  60                  


Ser Pro Tyr Glu Ile Ser Ile Arg Gln Arg Phe Ile Gly Lys Pro Asp 
65                  70                  75                  80  


Met Ala Tyr Arg Leu Ile Ser Ala Lys Met Pro Glu Val Ile Pro Ile 
                85                  90                  95      


Leu Glu Val Gln Phe Ser Lys Lys Met Glu Leu Leu Glu Asp Ala Leu 
            100                 105                 110         


Val Leu Arg Ser Ala Arg Thr Ser Ser Pro Ala Glu Lys Ser Cys Ser 
        115                 120                 125             


Val Trp His Ala Ala Ser Gly Leu Met Gly Arg Thr Leu His Arg Glu 
    130                 135                 140                 


Pro Pro Ala Gly Asp Gln Glu Gly Thr Ala Leu His Leu Gln Thr Ser 
145                 150                 155                 160 


Leu Pro Ala Leu Ser Glu Ala Asp Thr Gln Glu Leu Thr Gln Ile Leu 
                165                 170                 175     


Arg Arg Met Lys Gly Leu Ala Leu Glu Ala Glu Ser Glu Leu Glu Arg 
            180                 185                 190         


Gln Asp Glu Ala Leu Asp Gly Val Ala Ala Ala Val Asp Arg Ala Thr 
        195                 200                 205             


Leu Thr Ile Asp Lys His Asn Arg Arg Met Lys Arg Leu Thr 
    210                 215                 220         


<210> 6080
<211> 66
<212> PRT
<213> Homo sapiens

<400> 6080
Met Pro Gln Tyr Gln Thr Trp Glu Glu Phe Ser Arg Ala Ala Glu Lys 
1               5                   10                  15      


Leu Tyr Leu Ala Asp Pro Met Lys Ala Arg Val Val Leu Lys Tyr Arg 
            20                  25                  30          


His Ser Asp Gly Asn Leu Cys Val Lys Val Thr Asp Asp Leu Val Gln 
        35                  40                  45              


Trp His Leu Asn Tyr Cys Thr Leu Arg His Gly Ile Ala Gly Gly Leu 
    50                  55                  60                  


Glu Thr 
65      


<210> 6081
<211> 82
<212> PRT
<213> Homo sapiens

<400> 6081
Met Pro Gln Tyr Gln Thr Trp Glu Glu Phe Ser Arg Ala Ala Glu Lys 
1               5                   10                  15      


Leu Tyr Leu Ala Asp Pro Met Lys Ala Arg Val Val Leu Lys Tyr Arg 
            20                  25                  30          


His Ser Asp Gly Asn Leu Cys Val Lys Val Thr Asp Asp Leu Val Arg 
        35                  40                  45              


Gln Cys Leu Ala Leu Leu Leu Arg Leu Gln Cys Ser Gly Met Ile Ile 
    50                  55                  60                  


Ala His Cys Ile Leu Asp Leu Leu Gly Ser Ser Gly Pro Leu Ala Ser 
65                  70                  75                  80  


Ala Ser 
        


<210> 6082
<211> 216
<212> PRT
<213> Homo sapiens

<400> 6082
Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Ala Gln Thr Phe Ser Glu Thr Ser Ile Asn Phe Phe Pro Leu Thr 
        195                 200                 205             


Ala Ala Phe Cys His Val Arg Gly 
    210                 215     


<210> 6083
<211> 779
<212> PRT
<213> Homo sapiens

<400> 6083
Met Arg Ile Glu Glu Arg Lys Ser Gln His Leu Thr Gly Leu Thr Asp 
1               5                   10                  15      


Glu Lys Val Lys Ala Tyr Leu Ser Leu His Pro Gln Val Leu Asp Glu 
            20                  25                  30          


Phe Val Ser Glu Ser Val Ser Ala Glu Thr Val Glu Lys Trp Leu Lys 
        35                  40                  45              


Arg Lys Asn Asn Lys Ser Glu Asp Glu Ser Ala Pro Lys Glu Val Ser 
    50                  55                  60                  


Arg Tyr Gln Asp Thr Asn Met Gln Gly Val Val Tyr Glu Leu Asn Ser 
65                  70                  75                  80  


Tyr Ile Glu Gln Arg Leu Asp Thr Gly Gly Asp Asn Gln Leu Leu Leu 
                85                  90                  95      


Tyr Glu Leu Ser Ser Ile Ile Lys Ile Ala Thr Lys Ala Asp Gly Phe 
            100                 105                 110         


Ala Leu Tyr Phe Leu Gly Glu Cys Asn Asn Ser Leu Cys Ile Phe Thr 
        115                 120                 125             


Pro Pro Gly Ile Lys Glu Gly Lys Pro Arg Leu Ile Pro Ala Gly Pro 
    130                 135                 140                 


Ile Thr Gln Gly Thr Thr Val Ser Ala Tyr Val Ala Lys Ser Arg Lys 
145                 150                 155                 160 


Thr Leu Leu Val Glu Asp Ile Leu Gly Asp Glu Arg Phe Pro Arg Gly 
                165                 170                 175     


Thr Gly Leu Glu Ser Gly Thr Arg Ile Gln Ser Val Leu Cys Leu Pro 
            180                 185                 190         


Ile Val Thr Ala Ile Gly Asp Leu Ile Gly Ile Leu Glu Leu Tyr Arg 
        195                 200                 205             


His Trp Gly Lys Glu Ala Phe Cys Leu Ser His Gln Glu Val Ala Thr 
    210                 215                 220                 


Ala Asn Leu Ala Trp Ala Ser Val Ala Ile His Gln Val Gln Val Cys 
225                 230                 235                 240 


Arg Gly Leu Ala Lys Gln Thr Glu Leu Asn Asp Phe Leu Leu Asp Val 
                245                 250                 255     


Ser Lys Thr Tyr Phe Asp Asn Ile Val Ala Ile Asp Ser Leu Leu Glu 
            260                 265                 270         


His Ile Met Ile Tyr Ala Lys Asn Leu Val Asn Ala Asp Arg Cys Ala 
        275                 280                 285             


Leu Phe Gln Val Asp His Lys Asn Lys Glu Leu Tyr Ser Asp Leu Phe 
    290                 295                 300                 


Asp Ile Gly Glu Glu Lys Glu Gly Lys Pro Val Phe Lys Lys Thr Lys 
305                 310                 315                 320 


Glu Ile Arg Phe Ser Ile Glu Lys Gly Ile Ala Gly Gln Val Ala Arg 
                325                 330                 335     


Thr Gly Glu Val Leu Asn Ile Pro Asp Ala Tyr Ala Asp Pro Arg Phe 
            340                 345                 350         


Asn Arg Glu Val Asp Leu Tyr Thr Gly Tyr Thr Thr Arg Asn Ile Leu 
        355                 360                 365             


Cys Met Pro Ile Val Ser Arg Gly Ser Val Ile Gly Val Val Gln Met 
    370                 375                 380                 


Val Asn Lys Ile Ser Gly Ser Ala Phe Ser Lys Thr Asp Glu Asn Asn 
385                 390                 395                 400 


Phe Lys Met Phe Ala Val Phe Cys Ala Leu Ala Leu His Cys Ala Asn 
                405                 410                 415     


Met Tyr His Arg Ile Arg His Ser Glu Cys Ile Tyr Arg Val Thr Met 
            420                 425                 430         


Glu Lys Leu Ser Tyr His Ser Ile Cys Thr Ser Glu Glu Trp Gln Gly 
        435                 440                 445             


Leu Met Gln Phe Thr Leu Pro Val Arg Leu Cys Lys Glu Ile Glu Leu 
    450                 455                 460                 


Phe His Phe Asp Ile Gly Pro Phe Glu Asn Met Trp Pro Gly Ile Phe 
465                 470                 475                 480 


Val Tyr Met Val His Arg Ser Cys Gly Thr Ser Cys Phe Glu Leu Glu 
                485                 490                 495     


Lys Leu Cys Arg Phe Ile Met Ser Val Lys Lys Asn Tyr Arg Arg Val 
            500                 505                 510         


Pro Tyr His Asn Trp Lys His Ala Val Thr Val Ala His Cys Met Tyr 
        515                 520                 525             


Ala Ile Leu Gln Asn Asn His Thr Leu Phe Thr Asp Leu Glu Arg Lys 
    530                 535                 540                 


Gly Leu Leu Ile Ala Cys Leu Cys His Asp Leu Asp His Arg Gly Phe 
545                 550                 555                 560 


Ser Asn Ser Tyr Leu Gln Lys Phe Asp His Pro Leu Ala Ala Leu Tyr 
                565                 570                 575     


Ser Thr Ser Thr Met Glu Gln His His Phe Ser Gln Thr Val Ser Ile 
            580                 585                 590         


Leu Gln Leu Glu Gly His Asn Ile Phe Ser Thr Leu Ser Ser Ser Glu 
        595                 600                 605             


Tyr Glu Gln Val Leu Glu Ile Ile Arg Lys Ala Ile Ile Ala Thr Asp 
    610                 615                 620                 


Leu Ala Leu Tyr Phe Gly Asn Arg Lys Gln Leu Glu Glu Met Tyr Gln 
625                 630                 635                 640 


Thr Gly Ser Leu Asn Leu Asn Asn Gln Ser His Arg Asp Arg Val Ile 
                645                 650                 655     


Gly Leu Met Met Thr Ala Cys Asp Leu Cys Ser Val Thr Lys Leu Trp 
            660                 665                 670         


Pro Val Thr Lys Leu Thr Ala Asn Asp Ile Tyr Ala Glu Phe Trp Ala 
        675                 680                 685             


Glu Gly Asp Glu Met Lys Lys Leu Gly Ile Gln Pro Ile Pro Met Met 
    690                 695                 700                 


Asp Arg Asp Lys Lys Asp Glu Val Pro Gln Gly Gln Leu Gly Phe Tyr 
705                 710                 715                 720 


Asn Ala Val Ala Ile Pro Cys Tyr Thr Thr Leu Thr Gln Ile Leu Pro 
                725                 730                 735     


Pro Thr Glu Pro Leu Leu Lys Ala Cys Arg Asp Asn Leu Ser Gln Trp 
            740                 745                 750         


Glu Lys Val Ile Arg Gly Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro 
        755                 760                 765             


Ser Val Ala Gln Lys Ala Ala Ala Ser Glu Asp 
    770                 775                 


<210> 6084
<211> 221
<212> PRT
<213> Homo sapiens

<400> 6084
Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
65                  70                  75                  80  


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
                85                  90                  95      


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
            100                 105                 110         


Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
        115                 120                 125             


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
    130                 135                 140                 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
145                 150                 155                 160 


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
                165                 170                 175     


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
            180                 185                 190         


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
        195                 200                 205             


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
    210                 215                 220     


<210> 6085
<211> 237
<212> PRT
<213> Homo sapiens

<400> 6085
Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg 
65                  70                  75                  80  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
                85                  90                  95      


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
            100                 105                 110         


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
        115                 120                 125             


Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
    130                 135                 140                 


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
145                 150                 155                 160 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
                165                 170                 175     


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
            180                 185                 190         


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
        195                 200                 205             


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
    210                 215                 220                 


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
225                 230                 235         


<210> 6086
<211> 156
<212> PRT
<213> Homo sapiens

<400> 6086
Met Glu Thr Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys 
1               5                   10                  15      


Leu Glu Ala Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser 
            20                  25                  30          


Ile Glu Arg Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr 
        35                  40                  45              


Phe His His Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser 
    50                  55                  60                  


Leu Gly Met Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe 
65                  70                  75                  80  


Arg Thr Leu Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys 
                85                  90                  95      


Tyr Leu His Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His 
            100                 105                 110         


Glu Pro His Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn 
        115                 120                 125             


Val Ser Lys Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr 
    130                 135                 140                 


Ala Arg Asp Met Arg Met Lys Gly Leu Cys Ser His 
145                 150                 155     


<210> 6087
<211> 311
<212> PRT
<213> Homo sapiens

<400> 6087
Met Thr Gly Ser Ala Ala Asp Thr His Arg Cys Pro His Pro Lys Gly 
1               5                   10                  15      


Ala Lys Gly Thr Arg Ser Arg Ser Ser His Ala Arg Pro Val Ser Leu 
            20                  25                  30          


Ala Thr Ser Gly Gly Ser Glu Glu Glu Asp Lys Asp Gly Gly Val Leu 
        35                  40                  45              


Phe His Val Asn Lys Ser Gly Phe Pro Ile Asp Ser His Thr Trp Glu 
    50                  55                  60                  


Arg Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met 
65                  70                  75                  80  


Val Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro 
                85                  90                  95      


Gln Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln 
            100                 105                 110         


Ala Ile Gln Asn Tyr Met Lys Thr Leu His Tyr Leu Thr Asn Gly Gln 
        115                 120                 125             


Pro Ser Ile Glu Arg Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly 
    130                 135                 140                 


Asn Tyr Phe His His Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr 
145                 150                 155                 160 


Gly Ser Leu Gly Met Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu 
                165                 170                 175     


Thr Phe Arg Thr Leu Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr 
            180                 185                 190         


Lys Lys Tyr Leu His Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val 
        195                 200                 205             


Pro His Glu Pro His Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Lys Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu 
225                 230                 235                 240 


Lys Tyr Ala Arg Asp Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala 
                245                 250                 255     


His Ser Pro Thr Gln Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg 
            260                 265                 270         


Arg Arg Gln Ala Ser Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser 
        275                 280                 285             


Pro Ala Leu Pro Glu Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu 
    290                 295                 300                 


Val Gly Tyr Gln Ile Arg Ile 
305                 310     


<210> 6088
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6088
Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met Val 
1               5                   10                  15      


Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro Gln 
            20                  25                  30          


Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln Ala 
        35                  40                  45              


Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr Gln 
    50                  55                  60                  


Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu Thr 
65                  70                  75                  80  


Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu Ala 
                85                  90                  95      


Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser Ile Glu Arg 
            100                 105                 110         


Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe His His 
        115                 120                 125             


Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser Leu Gly Met 
    130                 135                 140                 


Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe Arg Thr Leu 
145                 150                 155                 160 


Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys Tyr Leu His 
                165                 170                 175     


Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His Glu Pro His 
            180                 185                 190         


Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn Val Ser Lys 
        195                 200                 205             


Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr Ala Arg Asp 
    210                 215                 220                 


Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala His Ser Pro Thr Gln 
225                 230                 235                 240 


Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg Arg Arg Gln Ala Ser 
                245                 250                 255     


Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser Pro Ala Leu Pro Glu 
            260                 265                 270         


Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu Val Gly Tyr Gln Ile 
        275                 280                 285             


Arg Ile 
    290 


<210> 6089
<211> 251
<212> PRT
<213> Homo sapiens

<400> 6089
Met Thr Ile Pro Asp Trp Leu Gln Ala Ile Gln Asn Tyr Met Lys Thr 
1               5                   10                  15      


Leu Gln Tyr Asn His Thr Gly Thr Gln Phe Phe Glu Ile Arg Lys Met 
            20                  25                  30          


Arg Pro Leu Ser Gly Leu Met Glu Thr Ala Lys Glu Met Thr Arg Glu 
        35                  40                  45              


Ser Leu Pro Ile Lys Cys Leu Glu Ala Val Ile Leu Gly Ile Tyr Leu 
    50                  55                  60                  


Thr Asn Gly Gln Pro Ser Ile Glu Arg Phe Pro Ile Ser Phe Lys Thr 
65                  70                  75                  80  


Tyr Phe Ser Gly Asn Tyr Phe His His Val Val Leu Gly Ile Tyr Cys 
                85                  90                  95      


Asn Gly Arg Tyr Gly Ser Leu Gly Met Ser Arg Arg Ala Glu Leu Met 
            100                 105                 110         


Asp Lys Pro Leu Thr Phe Arg Thr Leu Ser Asp Leu Ile Phe Asp Phe 
        115                 120                 125             


Glu Asp Ser Tyr Lys Lys Tyr Leu His Thr Val Lys Lys Val Lys Ile 
    130                 135                 140                 


Gly Leu Tyr Val Pro His Glu Pro His Ser Phe Gln Pro Ile Glu Trp 
145                 150                 155                 160 


Lys Gln Leu Val Leu Asn Val Ser Lys Met Leu Arg Ala Asp Ile Arg 
                165                 170                 175     


Lys Glu Leu Glu Lys Tyr Ala Arg Asp Met Arg Met Lys Ile Leu Lys 
            180                 185                 190         


Pro Ala Ser Ala His Ser Pro Thr Gln Val Arg Ser Arg Gly Lys Ser 
        195                 200                 205             


Leu Ser Pro Arg Arg Arg Gln Ala Ser Pro Pro Arg Arg Leu Gly Arg 
    210                 215                 220                 


Arg Glu Lys Ser Pro Ala Leu Pro Glu Lys Lys Val Ala Asp Leu Ser 
225                 230                 235                 240 


Thr Leu Asn Glu Val Gly Tyr Gln Ile Arg Ile 
                245                 250     


<210> 6090
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6090
Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met Val 
1               5                   10                  15      


Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro Gln 
            20                  25                  30          


Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln Ala 
        35                  40                  45              


Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr Gln 
    50                  55                  60                  


Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu Thr 
65                  70                  75                  80  


Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu Ala 
                85                  90                  95      


Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser Ile Glu Arg 
            100                 105                 110         


Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe His His 
        115                 120                 125             


Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser Leu Gly Met 
    130                 135                 140                 


Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe Arg Thr Leu 
145                 150                 155                 160 


Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys Tyr Leu His 
                165                 170                 175     


Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His Glu Pro His 
            180                 185                 190         


Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn Val Ser Lys 
        195                 200                 205             


Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr Ala Arg Asp 
    210                 215                 220                 


Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala His Ser Pro Thr Gln 
225                 230                 235                 240 


Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg Arg Arg Gln Ala Ser 
                245                 250                 255     


Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser Pro Ala Leu Pro Glu 
            260                 265                 270         


Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu Val Gly Tyr Gln Ile 
        275                 280                 285             


Arg Ile 
    290 


<210> 6091
<211> 240
<212> PRT
<213> Homo sapiens

<400> 6091
Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu Gly Phe 
145                 150                 155                 160 


Ser Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg Ile His 
                165                 170                 175     


Gln Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys Pro Glu 
            180                 185                 190         


Asn Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg 
        195                 200                 205             


Lys Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp Cys Pro 
    210                 215                 220                 


Gln Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu Asp Thr 
225                 230                 235                 240 


<210> 6092
<211> 172
<212> PRT
<213> Homo sapiens

<400> 6092
Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Val Leu Ala Cys Ile Asn 
                165                 170         


<210> 6093
<211> 281
<212> PRT
<213> Homo sapiens

<400> 6093
Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys Cys Arg 
                165                 170                 175     


Gly Glu Thr Val Ala Lys Glu Ile Ser Glu Ala Met Lys Ser Leu Pro 
            180                 185                 190         


Ala Leu Ile Glu Gln Gly Glu Gly Phe Ser Gln Val Leu Arg Met Gln 
        195                 200                 205             


Pro Val Ile His Leu Gln Arg Ile His Gln Glu Val Phe Ser Ser Cys 
    210                 215                 220                 


His Arg Lys Pro Asp Ala Lys Pro Glu Asn Phe Ile Thr Gln Ile Glu 
225                 230                 235                 240 


Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys Thr Ser Asp Met Val Leu 
                245                 250                 255     


Lys Arg Lys Gln Thr Lys Asp Cys Pro Gln Arg Lys Trp Tyr Pro Leu 
            260                 265                 270         


Arg Pro Lys Lys Ile Asn Leu Asp Thr 
        275                 280     


<210> 6094
<211> 75
<212> PRT
<213> Homo sapiens

<400> 6094
Met Asp Ser Asp Ile Lys Val Leu Glu Asp Gln Phe Asp Glu Ile Ile 
1               5                   10                  15      


Val Asp Ile Ala Thr Lys Arg Lys Gln Tyr Pro Arg Lys Ile Leu Glu 
            20                  25                  30          


Cys Val Ile Lys Thr Ile Lys Ala Lys Gln Glu Ile Leu Lys Gln Tyr 
        35                  40                  45              


His Pro Val Val His Pro Leu Asp Leu Lys Tyr Asp Pro Asp Pro Gly 
    50                  55                  60                  


Ala Lys Pro Gly Gly Leu Ala Leu Gly Ala Val 
65                  70                  75  


<210> 6095
<211> 92
<212> PRT
<213> Homo sapiens

<400> 6095
Met Glu Asp Tyr Gln Ala Ala Glu Glu Thr Ala Phe Val Val Asp Glu 
1               5                   10                  15      


Val Ser Asn Ile Val Lys Glu Ala Ile Glu Ser Ala Ile Gly Gly Asn 
            20                  25                  30          


Ala Tyr Gln His Ser Lys Val Asn Gln Trp Thr Thr Asn Val Val Glu 
        35                  40                  45              


Gln Thr Leu Ser Gln Leu Thr Lys Leu Gly Lys Pro Phe Lys Tyr Ile 
    50                  55                  60                  


Gly Asn Gly Val Leu Phe Leu Leu Tyr Leu Arg Asp Gly Phe Leu Thr 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Ser Ser Thr Arg Asn Asn Ser 
                85                  90          


<210> 6096
<211> 67
<212> PRT
<213> Homo sapiens

<400> 6096
Met Gln Lys Asn Gly Ala Gly Leu His Thr Ala Ser Ser Cys Phe Trp 
1               5                   10                  15      


Asp Ser Ser Thr Asp Gly Met Ile Phe Ile His Val Cys Glu Val Leu 
            20                  25                  30          


Leu Cys Glu Ile Tyr Asp Trp Lys Phe Pro Ile Phe Glu Cys Asn Ala 
        35                  40                  45              


Cys Leu Ser Pro Phe Lys Thr Phe Asn Asn Arg Leu Ala Lys Val Leu 
    50                  55                  60                  


Cys Val Ala 
65          


<210> 6097
<211> 113
<212> PRT
<213> Homo sapiens

<400> 6097
Met Glu Asp Tyr Gln Ala Ala Glu Glu Thr Ala Phe Val Val Asp Glu 
1               5                   10                  15      


Val Ser Asn Ile Val Lys Glu Ala Ile Glu Ser Ala Ile Gly Gly Asn 
            20                  25                  30          


Ala Tyr Gln His Ser Lys Val Asn Gln Trp Thr Thr Asn Val Val Glu 
        35                  40                  45              


Gln Thr Leu Ser Gln Leu Thr Lys Leu Gly Lys Pro Phe Lys Tyr Ile 
    50                  55                  60                  


Val Thr Cys Val Ile Met Gln Lys Asn Gly Ala Gly Leu His Thr Ala 
65                  70                  75                  80  


Ser Ser Cys Phe Trp Asp Ser Ser Thr Asp Gly Ser Cys Thr Val Arg 
                85                  90                  95      


Trp Glu Asn Lys Thr Met Tyr Cys Ile Val Ser Ala Phe Gly Leu Ser 
            100                 105                 110         


Ile 
    


<210> 6098
<211> 678
<212> PRT
<213> Homo sapiens

<400> 6098
Met Tyr Ala Ala Val Glu His Gly Pro Val Leu Cys Ser Asp Ser Asn 
1               5                   10                  15      


Ile Leu Cys Leu Ser Trp Lys Gly Arg Val Pro Lys Ser Glu Lys Glu 
            20                  25                  30          


Lys Pro Val Cys Arg Arg Arg Tyr Tyr Glu Glu Gly Trp Leu Ala Thr 
        35                  40                  45              


Gly Asn Gly Arg Gly Val Val Gly Val Thr Phe Thr Ser Ser His Cys 
    50                  55                  60                  


Arg Arg Asp Arg Ser Thr Pro Gln Arg Ile Asn Phe Asn Leu Arg Gly 
65                  70                  75                  80  


His Asn Ser Glu Val Val Leu Val Arg Trp Asn Glu Pro Tyr Gln Lys 
                85                  90                  95      


Leu Ala Thr Cys Asp Ala Asp Gly Gly Ile Phe Val Trp Ile Gln Tyr 
            100                 105                 110         


Glu Gly Arg Trp Ser Val Glu Leu Val Asn Asp Arg Gly Ala Gln Val 
        115                 120                 125             


Ser Asp Phe Thr Trp Ser His Asp Gly Thr Gln Ala Leu Ile Ser Tyr 
    130                 135                 140                 


Arg Asp Gly Phe Val Leu Val Gly Ser Val Ser Gly Gln Arg His Trp 
145                 150                 155                 160 


Ser Ser Glu Ile Asn Leu Glu Ser Gln Ile Thr Cys Gly Ile Trp Thr 
                165                 170                 175     


Pro Asp Asp Gln Gln Val Leu Phe Gly Thr Ala Asp Gly Gln Val Ile 
            180                 185                 190         


Val Met Asp Cys His Gly Arg Met Leu Ala His Val Leu Leu His Glu 
        195                 200                 205             


Ser Asp Gly Val Leu Gly Met Ser Trp Asn Tyr Pro Ile Phe Leu Val 
    210                 215                 220                 


Glu Asp Ser Ser Glu Ser Asp Thr Asp Ser Asp Asp Tyr Ala Pro Pro 
225                 230                 235                 240 


Gln Asp Gly Pro Ala Ala Tyr Pro Ile Pro Val Gln Asn Ile Lys Pro 
                245                 250                 255     


Leu Leu Thr Val Ser Phe Thr Ser Gly Asp Ile Ser Leu Met Asn Asn 
            260                 265                 270         


Tyr Asp Asp Leu Ser Pro Thr Val Ile Arg Ser Gly Leu Lys Glu Val 
        275                 280                 285             


Val Ala Gln Trp Cys Thr Gln Gly Asp Leu Leu Ala Val Ala Gly Met 
    290                 295                 300                 


Glu Arg Gln Thr Gln Leu Gly Glu Leu Pro Asn Gly Pro Leu Leu Lys 
305                 310                 315                 320 


Ser Ala Met Val Lys Phe Tyr Asn Val Arg Gly Glu His Ile Phe Thr 
                325                 330                 335     


Leu Asp Thr Leu Val Gln Arg Pro Ile Ile Ser Ile Cys Trp Gly His 
            340                 345                 350         


Arg Asp Ser Arg Leu Leu Met Ala Ser Gly Pro Ala Leu Tyr Val Val 
        355                 360                 365             


Arg Val Glu His Arg Val Ser Ser Leu Gln Leu Leu Cys Gln Gln Ala 
    370                 375                 380                 


Ile Ala Ser Thr Leu Arg Glu Asp Lys Asp Val Ser Lys Leu Thr Leu 
385                 390                 395                 400 


Pro Pro Arg Leu Cys Ser Tyr Leu Ser Thr Ala Phe Ile Pro Thr Ile 
                405                 410                 415     


Lys Pro Pro Ile Pro Asp Pro Asn Asn Met Arg Asp Phe Val Ser Tyr 
            420                 425                 430         


Pro Ser Ala Gly Asn Glu Arg Leu His Cys Thr Met Lys Arg Thr Glu 
        435                 440                 445             


Asp Asp Pro Glu Val Gly Gly Pro Cys Tyr Thr Leu Tyr Leu Glu Tyr 
    450                 455                 460                 


Leu Gly Gly Leu Val Pro Ile Leu Lys Gly Arg Arg Ile Ser Lys Leu 
465                 470                 475                 480 


Arg Pro Glu Phe Val Ile Met Asp Pro Arg Thr Asp Ser Lys Pro Asp 
                485                 490                 495     


Glu Ile Tyr Gly Asn Ser Leu Ile Ser Thr Val Ile Asp Ser Cys Asn 
            500                 505                 510         


Cys Ser Asp Ser Ser Asp Ile Glu Leu Ser Asp Asp Trp Ala Ala Lys 
        515                 520                 525             


Lys Ser Pro Lys Ile Ser Arg Ala Ser Lys Ser Pro Lys Leu Pro Arg 
    530                 535                 540                 


Ile Ser Ile Glu Ala Arg Lys Ser Pro Lys Leu Pro Arg Ala Ala Gln 
545                 550                 555                 560 


Glu Leu Ser Arg Ser Pro Arg Leu Pro Leu Arg Lys Pro Ser Val Gly 
                565                 570                 575     


Ser Pro Ser Leu Thr Arg Arg Glu Phe Pro Phe Glu Asp Ile Thr Gln 
            580                 585                 590         


His Asn Tyr Leu Ala Gln Val Thr Ser Asn Ile Trp Gly Thr Lys Phe 
        595                 600                 605             


Lys Ile Val Gly Leu Ala Ala Phe Leu Pro Thr Asn Leu Gly Ala Val 
    610                 615                 620                 


Ile Tyr Lys Thr Ser Leu Leu His Leu Gln Pro Arg Gln Met Thr Ile 
625                 630                 635                 640 


Tyr Leu Pro Glu Val Arg Lys Ile Ser Met Asp Tyr Ile Asn Leu Pro 
                645                 650                 655     


Val Phe Asn Pro Asn Val Phe Ser Glu Asp Glu Asp Asp Leu Pro Gly 
            660                 665                 670         


Asp Ala Val Trp Thr Asp 
        675             


<210> 6099
<211> 1543
<212> PRT
<213> Homo sapiens

<400> 6099
Met Tyr Ala Ala Val Glu His Gly Pro Val Leu Cys Ser Asp Ser Asn 
1               5                   10                  15      


Ile Leu Cys Leu Ser Trp Lys Gly Arg Val Pro Lys Ser Glu Lys Glu 
            20                  25                  30          


Lys Pro Val Cys Arg Arg Arg Tyr Tyr Glu Glu Gly Trp Leu Ala Thr 
        35                  40                  45              


Gly Asn Gly Arg Gly Val Val Gly Val Thr Phe Thr Ser Ser His Cys 
    50                  55                  60                  


Arg Arg Asp Arg Ser Thr Pro Gln Arg Ile Asn Phe Asn Leu Arg Gly 
65                  70                  75                  80  


His Asn Ser Glu Val Val Leu Val Arg Trp Asn Glu Pro Tyr Gln Lys 
                85                  90                  95      


Leu Ala Thr Cys Asp Ala Asp Gly Gly Ile Phe Val Trp Ile Gln Tyr 
            100                 105                 110         


Glu Gly Arg Trp Ser Val Glu Leu Val Asn Asp Arg Gly Ala Gln Val 
        115                 120                 125             


Ser Asp Phe Thr Trp Ser His Asp Gly Thr Gln Ala Leu Ile Ser Tyr 
    130                 135                 140                 


Arg Asp Gly Phe Val Leu Val Gly Ser Val Ser Gly Gln Arg His Trp 
145                 150                 155                 160 


Ser Ser Glu Ile Asn Leu Glu Ser Gln Ile Thr Cys Gly Ile Trp Thr 
                165                 170                 175     


Pro Asp Asp Gln Gln Val Leu Phe Gly Thr Ala Asp Gly Gln Val Ile 
            180                 185                 190         


Val Met Asp Cys His Gly Arg Met Leu Ala His Val Leu Leu His Glu 
        195                 200                 205             


Ser Asp Gly Val Leu Gly Met Ser Trp Asn Tyr Pro Ile Phe Leu Val 
    210                 215                 220                 


Glu Asp Ser Ser Glu Ser Asp Thr Asp Ser Asp Asp Tyr Ala Pro Pro 
225                 230                 235                 240 


Gln Asp Gly Pro Ala Ala Tyr Pro Ile Pro Val Gln Asn Ile Lys Pro 
                245                 250                 255     


Leu Leu Thr Val Ser Phe Thr Ser Gly Asp Ile Ser Leu Met Asn Asn 
            260                 265                 270         


Tyr Asp Asp Leu Ser Pro Thr Val Ile Arg Ser Gly Leu Lys Glu Val 
        275                 280                 285             


Val Ala Gln Trp Cys Thr Gln Gly Asp Leu Leu Ala Val Ala Gly Met 
    290                 295                 300                 


Glu Arg Gln Thr Gln Leu Gly Glu Leu Pro Asn Gly Pro Leu Leu Lys 
305                 310                 315                 320 


Ser Ala Met Val Lys Phe Tyr Asn Val Arg Gly Glu His Ile Phe Thr 
                325                 330                 335     


Leu Asp Thr Leu Val Gln Arg Pro Ile Ile Ser Ile Cys Trp Gly His 
            340                 345                 350         


Arg Asp Ser Arg Leu Leu Met Ala Ser Gly Pro Ala Leu Tyr Val Val 
        355                 360                 365             


Arg Val Glu His Arg Val Ser Ser Leu Gln Leu Leu Cys Gln Gln Ala 
    370                 375                 380                 


Ile Ala Ser Thr Leu Arg Glu Asp Lys Asp Val Ser Lys Leu Thr Leu 
385                 390                 395                 400 


Pro Pro Arg Leu Cys Ser Tyr Leu Ser Thr Ala Phe Ile Pro Thr Ile 
                405                 410                 415     


Lys Pro Pro Ile Pro Asp Pro Asn Asn Met Arg Asp Phe Val Ser Tyr 
            420                 425                 430         


Pro Ser Ala Gly Asn Glu Arg Leu His Cys Thr Met Lys Arg Thr Glu 
        435                 440                 445             


Asp Asp Pro Glu Val Gly Gly Pro Cys Tyr Thr Leu Tyr Leu Glu Tyr 
    450                 455                 460                 


Leu Gly Gly Leu Val Pro Ile Leu Lys Gly Arg Arg Ile Ser Lys Leu 
465                 470                 475                 480 


Arg Pro Glu Phe Val Ile Met Asp Pro Arg Thr Asp Ser Lys Pro Asp 
                485                 490                 495     


Glu Ile Tyr Gly Asn Ser Leu Ile Ser Thr Val Ile Asp Ser Cys Asn 
            500                 505                 510         


Cys Ser Asp Ser Ser Asp Ile Glu Leu Ser Asp Asp Trp Ala Ala Lys 
        515                 520                 525             


Lys Ser Pro Lys Ile Ser Arg Ala Ser Lys Ser Pro Lys Leu Pro Arg 
    530                 535                 540                 


Ile Ser Ile Glu Ala Arg Lys Ser Pro Lys Leu Pro Arg Ala Ala Gln 
545                 550                 555                 560 


Glu Leu Ser Arg Ser Pro Arg Leu Pro Leu Arg Lys Pro Ser Val Gly 
                565                 570                 575     


Ser Pro Ser Leu Thr Arg Arg Glu Phe Pro Phe Glu Asp Ile Thr Gln 
            580                 585                 590         


His Asn Tyr Leu Ala Gln Val Thr Ser Asn Ile Trp Gly Thr Lys Phe 
        595                 600                 605             


Lys Ile Val Gly Leu Ala Ala Phe Leu Pro Thr Asn Leu Gly Ala Val 
    610                 615                 620                 


Ile Tyr Lys Thr Ser Leu Leu His Leu Gln Pro Arg Gln Met Thr Ile 
625                 630                 635                 640 


Tyr Leu Pro Glu Val Arg Lys Ile Ser Met Asp Tyr Ile Asn Leu Pro 
                645                 650                 655     


Val Phe Asn Pro Asn Val Phe Ser Glu Asp Glu Asp Asp Leu Pro Val 
            660                 665                 670         


Thr Gly Ala Ser Gly Val Pro Glu Asn Ser Pro Pro Cys Thr Val Asn 
        675                 680                 685             


Ile Pro Ile Ala Pro Ile His Ser Ser Ala Gln Ala Met Ser Pro Thr 
    690                 695                 700                 


Gln Ser Ile Gly Leu Val Gln Ser Leu Leu Ala Asn Gln Asn Val Gln 
705                 710                 715                 720 


Leu Asp Val Leu Thr Asn Gln Thr Thr Ala Val Gly Thr Ala Glu His 
                725                 730                 735     


Ala Gly Asp Ser Ala Thr Gln Tyr Pro Val Ser Asn Arg Tyr Ser Asn 
            740                 745                 750         


Pro Gly Gln Val Ile Phe Gly Ser Val Glu Met Gly Arg Ile Ile Gln 
        755                 760                 765             


Asn Pro Pro Pro Leu Ser Leu Pro Pro Pro Pro Gln Gly Pro Met Gln 
    770                 775                 780                 


Leu Ser Thr Val Gly His Gly Asp Arg Asp His Glu His Leu Gln Lys 
785                 790                 795                 800 


Ser Ala Lys Ala Leu Arg Pro Thr Pro Gln Leu Ala Ala Glu Gly Asp 
                805                 810                 815     


Ala Val Val Phe Ser Ala Pro Gln Glu Val Gln Val Thr Lys Ile Asn 
            820                 825                 830         


Pro Pro Pro Pro Tyr Pro Gly Thr Ile Pro Ala Ala Pro Thr Thr Ala 
        835                 840                 845             


Ala Pro Pro Pro Pro Leu Pro Pro Pro Gln Pro Pro Val Asp Val Cys 
    850                 855                 860                 


Leu Lys Lys Gly Asp Phe Ser Leu Tyr Pro Thr Ser Val His Tyr Gln 
865                 870                 875                 880 


Thr Pro Leu Gly Tyr Glu Arg Ile Thr Thr Phe Asp Ser Ser Gly Asn 
                885                 890                 895     


Val Glu Glu Val Cys Arg Pro Arg Thr Arg Met Leu Cys Ser Gln Asn 
            900                 905                 910         


Thr Tyr Thr Leu Pro Gly Pro Gly Ser Ser Ala Thr Leu Arg Leu Thr 
        915                 920                 925             


Ala Thr Glu Lys Lys Val Pro Gln Pro Cys Ser Ser Ala Thr Leu Asn 
    930                 935                 940                 


Arg Leu Thr Val Pro Arg Tyr Ser Ile Pro Thr Gly Asp Pro Pro Pro 
945                 950                 955                 960 


Tyr Pro Glu Ile Ala Ser Gln Leu Ala Gln Gly Arg Gly Ala Ala Gln 
                965                 970                 975     


Arg Ser Asp Asn Ser Leu Ile His Ala Thr Leu Arg Arg Asn Asn Arg 
            980                 985                 990         


Glu Ala Thr Leu Lys Met Ala Gln  Leu Ala Asp Ser Pro  Arg Ala Pro 
        995                 1000                 1005             


Leu Gln  Pro Leu Ala Lys Ser  Lys Gly Gly Pro Gly  Gly Val Val 
    1010                 1015                 1020             


Thr Gln  Leu Pro Ala Arg Pro  Pro Pro Ala Leu Tyr  Thr Cys Ser 
    1025                 1030                 1035             


Gln Cys  Ser Gly Thr Gly Pro  Ser Ser Gln Pro Gly  Ala Ser Leu 
    1040                 1045                 1050             


Ala His  Thr Ala Ser Ala Ser  Pro Leu Ala Ser Gln  Ser Ser Tyr 
    1055                 1060                 1065             


Ser Leu  Leu Ser Pro Pro Asp  Ser Ala Arg Asp Arg  Thr Asp Tyr 
    1070                 1075                 1080             


Val Asn  Ser Ala Phe Thr Glu  Asp Glu Ala Leu Ser  Gln His Cys 
    1085                 1090                 1095             


Gln Leu  Glu Lys Pro Leu Arg  His Pro Pro Leu Pro  Glu Ala Ala 
    1100                 1105                 1110             


Val Thr  Leu Lys Arg Pro Pro  Pro Tyr Gln Trp Asp  Pro Met Leu 
    1115                 1120                 1125             


Gly Glu  Asp Val Trp Val Pro  Gln Glu Arg Thr Ala  Gln Thr Ser 
    1130                 1135                 1140             


Gly Pro  Asn Pro Leu Lys Leu  Ser Ser Leu Met Leu  Ser Gln Gly 
    1145                 1150                 1155             


Gln His  Leu Asp Val Ser Arg  Leu Pro Phe Ile Ser  Pro Lys Ser 
    1160                 1165                 1170             


Pro Ala  Ser Pro Thr Ala Thr  Phe Gln Thr Gly Tyr  Gly Met Gly 
    1175                 1180                 1185             


Val Pro  Tyr Pro Gly Ser Tyr  Asn Asn Pro Pro Leu  Pro Gly Val 
    1190                 1195                 1200             


Gln Ala  Pro Cys Ser Pro Lys  Asp Ala Leu Ser Pro  Thr Gln Phe 
    1205                 1210                 1215             


Ala Gln  Gln Glu Pro Ala Val  Val Leu Gln Pro Leu  Tyr Pro Pro 
    1220                 1225                 1230             


Ser Leu  Ser Tyr Cys Thr Leu  Pro Pro Met Tyr Pro  Gly Ser Ser 
    1235                 1240                 1245             


Thr Cys  Ser Ser Leu Gln Leu  Pro Pro Val Ala Leu  His Pro Trp 
    1250                 1255                 1260             


Ser Ser  Tyr Ser Ala Cys Pro  Pro Met Gln Asn Pro  Gln Gly Thr 
    1265                 1270                 1275             


Leu Pro  Pro Lys Pro His Leu  Val Val Glu Lys Pro  Leu Val Ser 
    1280                 1285                 1290             


Pro Pro  Pro Ala Asp Leu Gln  Ser His Leu Gly Thr  Glu Val Met 
    1295                 1300                 1305             


Val Glu  Thr Ala Asp Asn Phe  Gln Glu Val Leu Ser  Leu Thr Glu 
    1310                 1315                 1320             


Ser Pro  Val Pro Gln Arg Thr  Glu Lys Phe Gly Lys  Lys Asn Arg 
    1325                 1330                 1335             


Lys Arg  Leu Asp Ser Arg Ala  Glu Glu Gly Ser Val  Gln Ala Ile 
    1340                 1345                 1350             


Thr Glu  Gly Lys Val Lys Lys  Glu Ala Arg Thr Leu  Ser Asp Phe 
    1355                 1360                 1365             


Asn Ser  Leu Ile Ser Ser Pro  His Leu Gly Arg Glu  Lys Lys Lys 
    1370                 1375                 1380             


Val Lys  Ser Gln Lys Asp Gln  Leu Lys Ser Lys Lys  Leu Asn Lys 
    1385                 1390                 1395             


Thr Asn  Glu Phe Gln Asp Ser  Ser Glu Ser Glu Pro  Glu Leu Phe 
    1400                 1405                 1410             


Ile Ser  Gly Asp Glu Leu Met  Asn Gln Ser Gln Gly  Ser Arg Lys 
    1415                 1420                 1425             


Gly Trp  Lys Ser Lys Arg Ser  Pro Arg Ala Ala Gly  Glu Leu Glu 
    1430                 1435                 1440             


Glu Ala  Lys Cys Arg Arg Ala  Ser Glu Lys Glu Asp  Gly Arg Leu 
    1445                 1450                 1455             


Gly Ser  Gln Gly Phe Val Tyr  Val Met Ala Asn Lys  Gln Pro Leu 
    1460                 1465                 1470             


Trp Asn  Glu Ala Thr Gln Val  Tyr Gln Leu Asp Phe  Gly Gly Arg 
    1475                 1480                 1485             


Val Thr  Gln Glu Ser Ala Lys  Asn Phe Gln Ile Glu  Leu Glu Gly 
    1490                 1495                 1500             


Arg Gln  Val Met Gln Phe Gly  Arg Ile Asp Gly Ser  Ala Tyr Ile 
    1505                 1510                 1515             


Leu Asp  Phe Gln Tyr Pro Phe  Ser Ala Val Gln Ala  Phe Ala Val 
    1520                 1525                 1530             


Ala Leu  Ala Asn Val Thr Gln  Arg Leu Lys 
    1535                 1540             


<210> 6100
<211> 1077
<212> PRT
<213> Homo sapiens

<400> 6100
Met Asp Ser Lys Met Lys Lys Met Ala Glu Leu Gln Leu Ser Val Val 
1               5                   10                  15      


Ser Asp Pro Lys Asn Arg Lys Ala Ile Glu Asn Gln Ile Gln Gln Trp 
            20                  25                  30          


Glu Gln Asn Leu Glu Lys Phe His Met Asp Leu Phe Arg Met Arg Cys 
        35                  40                  45              


Tyr Leu Ala Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Ser Leu 
    50                  55                  60                  


Leu Ala Ala Ala Ser Arg Pro Ser Lys Leu Ala Leu Gly Arg Leu Gly 
65                  70                  75                  80  


Ile Leu Ser Val Ser Ser Phe His Ala Leu Val Cys Ser Arg Asp Asp 
                85                  90                  95      


Ser Ala Leu Arg Lys Arg Thr Leu Ser Leu Thr Gln Arg Gly Arg Asn 
            100                 105                 110         


Lys Lys Gly Ile Phe Ser Ser Leu Lys Gly Leu Asp Thr Leu Ala Arg 
        115                 120                 125             


Lys Gly Lys Glu Lys Arg Pro Ser Ile Thr Gln Ile Phe Asp Ser Ser 
    130                 135                 140                 


Gly Ser His Gly Phe Ser Gly Thr Gln Leu Pro Gln Asn Ser Ser Asn 
145                 150                 155                 160 


Ser Ser Glu Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp 
                165                 170                 175     


Gly Val Pro Arg Asp Asn Ala Trp Glu Ile Gln Thr Tyr Val His Phe 
            180                 185                 190         


Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val 
        195                 200                 205             


Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser 
    210                 215                 220                 


His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr 
225                 230                 235                 240 


Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu 
                245                 250                 255     


Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr 
            260                 265                 270         


Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu 
        275                 280                 285             


Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly 
    290                 295                 300                 


Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu 
305                 310                 315                 320 


Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu 
                325                 330                 335     


Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp 
            340                 345                 350         


Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser 
        355                 360                 365             


Arg Asp Gln Lys Ser Leu Leu Pro Pro Pro Asn Gln Ser Gln Leu Leu 
    370                 375                 380                 


Glu Glu Phe Leu Asp Asn Phe Lys Lys Asn Thr Ala Asn Asp Phe Ser 
385                 390                 395                 400 


Asn Val Pro Asp Ile Thr Thr Gly Leu Lys Arg Ser Gln Thr Asp Gly 
                405                 410                 415     


Thr Leu Asp Gln Val Ser His Arg Glu Lys Met Glu Gln Thr Phe Arg 
            420                 425                 430         


Ser Ala Glu Gln Ile Thr Ala Leu Cys Arg Ser Phe Asn Asp Ser Gln 
        435                 440                 445             


Ala Asn Gly Met Glu Gly Pro Arg Glu Asn Gln Asp Pro Pro Pro Arg 
    450                 455                 460                 


Ser Leu Ala Arg His Leu Ser Asp Ala Asp Arg Leu Arg Lys Val Ile 
465                 470                 475                 480 


Gln Glu Leu Val Asp Thr Glu Lys Ser Tyr Val Lys Asp Leu Ser Cys 
                485                 490                 495     


Leu Phe Glu Leu Tyr Leu Glu Pro Leu Gln Asn Glu Thr Phe Leu Thr 
            500                 505                 510         


Gln Asp Glu Met Glu Ser Leu Phe Gly Ser Leu Pro Glu Met Leu Glu 
        515                 520                 525             


Phe Gln Lys Val Phe Leu Glu Thr Leu Glu Asp Gly Ile Ser Ala Ser 
    530                 535                 540                 


Ser Asp Phe Asn Thr Leu Glu Thr Pro Ser Gln Phe Arg Lys Leu Leu 
545                 550                 555                 560 


Phe Ser Leu Gly Gly Ser Phe Leu Tyr Tyr Ala Asp His Phe Lys Leu 
                565                 570                 575     


Tyr Ser Gly Phe Cys Ala Asn His Ile Lys Val Gln Lys Val Leu Glu 
            580                 585                 590         


Arg Ala Lys Thr Asp Lys Ala Phe Lys Ala Phe Leu Asp Ala Arg Asn 
        595                 600                 605             


Pro Thr Lys Gln His Ser Ser Thr Leu Glu Ser Tyr Leu Ile Lys Pro 
    610                 615                 620                 


Val Gln Arg Val Leu Lys Tyr Pro Leu Leu Leu Lys Glu Leu Val Ser 
625                 630                 635                 640 


Leu Thr Asp Gln Glu Ser Glu Glu His Tyr His Leu Thr Glu Ala Leu 
                645                 650                 655     


Lys Ala Met Glu Lys Val Ala Ser His Ile Asn Glu Met Gln Lys Ile 
            660                 665                 670         


Tyr Glu Asp Tyr Gly Thr Val Phe Asp Gln Leu Val Ala Glu Gln Ser 
        675                 680                 685             


Gly Thr Glu Lys Glu Val Thr Glu Leu Ser Met Gly Glu Leu Leu Met 
    690                 695                 700                 


His Ser Thr Val Ser Trp Leu Asn Pro Phe Leu Ser Leu Gly Lys Ala 
705                 710                 715                 720 


Arg Lys Asp Leu Glu Leu Thr Val Phe Val Phe Lys Arg Ala Val Ile 
                725                 730                 735     


Leu Val Tyr Lys Glu Asn Cys Lys Leu Lys Lys Lys Leu Pro Ser Asn 
            740                 745                 750         


Ser Arg Pro Ala His Asn Ser Thr Asp Leu Asp Pro Phe Lys Phe Arg 
        755                 760                 765             


Trp Leu Ile Pro Ile Ser Ala Leu Gln Val Arg Leu Gly Asn Pro Ala 
    770                 775                 780                 


Gly Thr Glu Asn Asn Ser Ile Trp Glu Leu Ile His Thr Lys Ser Glu 
785                 790                 795                 800 


Ile Glu Gly Arg Pro Glu Thr Ile Phe Gln Leu Cys Cys Ser Asp Ser 
                805                 810                 815     


Glu Ser Lys Thr Asn Ile Val Lys Val Ile Arg Ser Ile Leu Arg Glu 
            820                 825                 830         


Asn Phe Arg Arg His Ile Lys Cys Glu Leu Pro Leu Glu Lys Thr Cys 
        835                 840                 845             


Lys Asp Arg Leu Val Pro Leu Lys Asn Arg Val Pro Val Ser Ala Lys 
    850                 855                 860                 


Leu Ala Ser Ser Arg Ser Leu Lys Val Leu Lys Asn Ser Ser Ser Asn 
865                 870                 875                 880 


Glu Trp Thr Gly Glu Thr Gly Lys Gly Thr Leu Leu Asp Ser Asp Glu 
                885                 890                 895     


Gly Ser Leu Ser Ser Gly Thr Gln Ser Ser Gly Cys Pro Thr Ala Glu 
            900                 905                 910         


Gly Arg Gln Asp Ser Lys Ser Thr Ser Pro Gly Lys Tyr Pro His Pro 
        915                 920                 925             


Gly Leu Ala Asp Phe Ala Asp Asn Leu Ile Lys Glu Ser Asp Ile Leu 
    930                 935                 940                 


Ser Asp Glu Asp Asp Asp His Arg Gln Thr Val Lys Gln Gly Ser Pro 
945                 950                 955                 960 


Thr Lys Asp Ile Glu Ile Gln Phe Gln Arg Leu Arg Ile Ser Glu Asp 
                965                 970                 975     


Pro Asp Val His Pro Glu Ala Glu Gln Gln Pro Gly Pro Glu Ser Gly 
            980                 985                 990         


Glu Gly Gln Lys Gly Gly Glu Gln  Pro Lys Leu Val Arg  Gly His Phe 
        995                 1000                 1005             


Cys Pro  Ile Lys Arg Lys Ala  Asn Ser Thr Lys Arg  Asp Arg Gly 
    1010                 1015                 1020             


Thr Leu  Leu Lys Ala Gln Ile  Arg His Gln Ser Leu  Asp Ser Gln 
    1025                 1030                 1035             


Ser Glu  Asn Ala Thr Ile Asp  Leu Asn Ser Val Leu  Glu Arg Glu 
    1040                 1045                 1050             


Phe Ser  Val Gln Ser Leu Thr  Ser Val Val Ser Glu  Glu Cys Phe 
    1055                 1060                 1065             


Tyr Glu  Thr Glu Ser His Gly  Lys Ser 
    1070                 1075         


<210> 6101
<211> 192
<212> PRT
<213> Homo sapiens

<400> 6101
Met Ser Gln Cys Ala Cys Leu Glu Glu Val His Leu Pro Asn Ile Lys 
1               5                   10                  15      


Pro Gly Glu Gly Leu Gly Met Tyr Ile Lys Ser Thr Tyr Asp Gly Leu 
            20                  25                  30          


His Val Ile Thr Gly Thr Thr Glu Asn Val Gly Trp Gln Leu Lys Asn 
        35                  40                  45              


Leu Val Lys Lys Leu Arg Glu Asn Pro Thr Gly Val Val Leu Leu Leu 
    50                  55                  60                  


Lys Lys Arg Pro Thr Gly Ser Phe Asn Phe Thr Pro Ala Pro Leu Lys 
65                  70                  75                  80  


Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Thr Ser Pro Pro Pro Ala 
                85                  90                  95      


Thr Thr Gln Ser Pro Glu Ser Thr Met Asp Thr Ser Leu Lys Lys Glu 
            100                 105                 110         


Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro Ala Val Pro 
        115                 120                 125             


Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly Gly Ser Ser 
    130                 135                 140                 


Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu Ser Pro Asn 
145                 150                 155                 160 


Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe Thr Ile Ala Asp 
                165                 170                 175     


Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Thr Asn Ile Leu Pro Thr 
            180                 185                 190         


<210> 6102
<211> 555
<212> PRT
<213> Homo sapiens

<400> 6102
Met Glu Pro Val Thr Lys Trp Ser Pro Lys Gln Val Val Asp Trp Thr 
1               5                   10                  15      


Arg Gly Leu Asp Asp Cys Leu Gln Gln Tyr Val His Lys Phe Glu Arg 
            20                  25                  30          


Glu Lys Ile Asn Gly Glu Gln Leu Leu Gln Ile Ser His Gln Asp Leu 
        35                  40                  45              


Glu Glu Leu Gly Val Thr Arg Ile Gly His Gln Glu Leu Val Leu Glu 
    50                  55                  60                  


Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu Glu Thr Asp Asn 
65                  70                  75                  80  


Met Lys Asn Leu Val Leu Lys Leu Arg Ala Ser Ser His Asn Leu Gln 
                85                  90                  95      


Asn Tyr Ile Ser Ser Arg Arg Lys Ser Pro Ala Tyr Asp Gly Asn Thr 
            100                 105                 110         


Ser Arg Lys Ala Pro Asn Glu Phe Leu Thr Ser Val Val Glu Leu Ile 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Ala Trp Leu Asp Arg Ala Pro Phe Thr 
    130                 135                 140                 


Gly Ile Thr Asp Phe Ser Val Thr Lys Asn Lys Ile Ile Gln Leu Cys 
145                 150                 155                 160 


Leu Asp Leu Thr Thr Thr Val Gln Lys Asp Cys Phe Val Ala Glu Met 
                165                 170                 175     


Glu Asp Lys Val Leu Thr Val Val Lys Val Leu Asn Gly Ile Cys Asp 
            180                 185                 190         


Lys Thr Ile Arg Ser Thr Thr Asp Pro Val Met Ser Gln Cys Ala Cys 
        195                 200                 205             


Leu Glu Glu Val His Leu Pro Asn Ile Lys Pro Gly Glu Gly Leu Gly 
    210                 215                 220                 


Met Tyr Ile Lys Ser Thr Tyr Asp Gly Leu His Val Ile Thr Gly Thr 
225                 230                 235                 240 


Thr Glu Asn Ser Pro Ala Asp Arg Ser Gln Lys Ile His Ala Gly Asp 
                245                 250                 255     


Glu Val Ile Gln Val Asn Gln Gln Thr Val Val Gly Trp Gln Leu Lys 
            260                 265                 270         


Asn Leu Val Lys Lys Leu Arg Glu Asn Pro Thr Gly Val Val Leu Leu 
        275                 280                 285             


Leu Lys Lys Arg Pro Thr Gly Ser Phe Asn Phe Thr Pro Ala Pro Leu 
    290                 295                 300                 


Lys Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Thr Ser Pro Pro Pro 
305                 310                 315                 320 


Ala Thr Thr Gln Ser Pro Glu Ser Thr Met Asp Thr Ser Leu Lys Lys 
                325                 330                 335     


Glu Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro Ala Val 
            340                 345                 350         


Pro Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly Gly Ser 
        355                 360                 365             


Ser Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu Ser Pro 
    370                 375                 380                 


Asn Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe Thr Ile Ala 
385                 390                 395                 400 


Asp Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Thr Asn Ile Leu Pro 
                405                 410                 415     


Thr Lys Met Arg Glu Lys Thr Pro Ser Tyr Gly Lys Pro Arg Pro Leu 
            420                 425                 430         


Ser Met Pro Ala Asp Gly Asn Trp Met Gly Ile Val Asp Pro Phe Ala 
        435                 440                 445             


Arg Pro Arg Gly His Gly Arg Lys Gly Glu Asp Ala Leu Cys Arg Tyr 
    450                 455                 460                 


Phe Ser Asn Glu Arg Ile Pro Pro Ile Ile Glu Glu Ser Ser Ser Pro 
465                 470                 475                 480 


Pro Tyr Arg Phe Ser Arg Pro Thr Thr Glu Arg His Leu Val Arg Gly 
                485                 490                 495     


Ala Asp Tyr Ile Arg Gly Ser Arg Cys Tyr Ile Asn Ser Asp Leu His 
            500                 505                 510         


Ser Ser Ala Thr Ile Pro Phe Gln Glu Glu Gly Thr Lys Lys Lys Ser 
        515                 520                 525             


Gly Ser Ser Ala Thr Lys Ser Ser Ser Thr Glu Pro Ser Leu Leu Val 
    530                 535                 540                 


Ser Trp Phe Thr Arg Leu Lys Leu Leu Thr His 
545                 550                 555 


<210> 6103
<211> 235
<212> PRT
<213> Homo sapiens

<400> 6103
Met Arg Ser Arg Val Leu Trp Gly Ala Ala Arg Trp Leu Trp Pro Arg 
1               5                   10                  15      


Arg Ala Val Gly Pro Ala Arg Arg Pro Leu Ser Ser Gly Ser Pro Pro 
            20                  25                  30          


Leu Glu Glu Leu Phe Thr Arg Gly Gly Pro Leu Arg Thr Phe Leu Glu 
        35                  40                  45              


Arg Gln Ala Gly Ser Glu Ala His Leu Lys Val Arg Arg Pro Glu Leu 
    50                  55                  60                  


Leu Ala Val Ile Lys Leu Leu Asn Glu Lys Glu Arg Glu Leu Arg Glu 
65                  70                  75                  80  


Thr Glu His Leu Leu His Asp Glu Asn Glu Asp Leu Arg Lys Leu Ala 
                85                  90                  95      


Glu Asn Glu Ile Thr Leu Cys Gln Lys Glu Ile Thr Gln Leu Lys His 
            100                 105                 110         


Gln Ile Ile Leu Leu Leu Val Pro Ser Glu Glu Thr Asp Glu Asn Asp 
        115                 120                 125             


Leu Ile Leu Glu Val Thr Ala Gly Val Gly Gly Gly Leu Arg His Ala 
    130                 135                 140                 


Ser Ala Ser Ile Gly Gly Ser Glu Ala Tyr Arg His Met Lys Phe Glu 
145                 150                 155                 160 


Gly Gly Val His Arg Val Gln Arg Val Pro Lys Thr Glu Lys Gln Gly 
                165                 170                 175     


Arg Val His Thr Ser Thr Met Thr Val Ala Ile Leu Pro Gln Pro Thr 
            180                 185                 190         


Glu Ile Asn Leu Val Ile Asn Pro Lys Asp Leu Arg Ile Asp Thr Lys 
        195                 200                 205             


Arg Ala Ser Gly Ala Gly Gly Gln His Val Asn Thr Thr Asp Ser Ala 
    210                 215                 220                 


Val Arg Ile Val His Leu Pro Thr Asp Trp Lys 
225                 230                 235 


<210> 6104
<211> 271
<212> PRT
<213> Homo sapiens

<400> 6104
Met Arg Ser Arg Val Leu Trp Gly Ala Ala Arg Trp Leu Trp Pro Arg 
1               5                   10                  15      


Arg Ala Val Gly Pro Ala Arg Arg Pro Leu Ser Ser Gly Ser Pro Pro 
            20                  25                  30          


Leu Glu Glu Leu Phe Thr Arg Gly Gly Pro Leu Arg Thr Phe Leu Glu 
        35                  40                  45              


Arg Gln Ala Gly Ser Glu Ala His Leu Lys Val Arg Arg Pro Glu Leu 
    50                  55                  60                  


Leu Ala Val Ile Lys Leu Leu Asn Glu Lys Glu Arg Glu Leu Arg Glu 
65                  70                  75                  80  


Thr Glu His Leu Leu His Asp Glu Asn Glu Asp Leu Arg Lys Leu Ala 
                85                  90                  95      


Glu Asn Glu Ile Thr Leu Cys Gln Lys Glu Ile Thr Gln Leu Lys His 
            100                 105                 110         


Gln Ile Ile Leu Leu Leu Val Pro Ser Glu Glu Thr Asp Glu Asn Asp 
        115                 120                 125             


Leu Ile Leu Glu Val Thr Ala Gly Val Gly Gly Gln Glu Ala Met Leu 
    130                 135                 140                 


Phe Thr Ser Glu Ile Phe Asp Met Tyr Gln Gln Tyr Ala Ala Phe Lys 
145                 150                 155                 160 


Arg Trp His Phe Glu Thr Leu Glu Tyr Phe Pro Ser Glu Leu Gly Gly 
                165                 170                 175     


Leu Arg His Ala Ser Ala Ser Ile Gly Gly Ser Glu Ala Tyr Arg His 
            180                 185                 190         


Met Lys Phe Glu Gly Gly Val His Arg Val Gln Arg Val Pro Lys Thr 
        195                 200                 205             


Glu Lys Gln Gly Arg Val His Thr Ser Thr Met Thr Val Ala Ile Leu 
    210                 215                 220                 


Pro Gln Pro Thr Glu Ile Asn Leu Val Ile Asn Pro Lys Asp Leu Arg 
225                 230                 235                 240 


Ile Asp Thr Lys Arg Ala Ser Gly Ala Gly Gly Gln His Val Asn Thr 
                245                 250                 255     


Thr Asp Ser Ala Val Arg Ile Val His Leu Pro Thr Asp Trp Lys 
            260                 265                 270     


<210> 6105
<211> 380
<212> PRT
<213> Homo sapiens

<400> 6105
Met Arg Ser Arg Val Leu Trp Gly Ala Ala Arg Trp Leu Trp Pro Arg 
1               5                   10                  15      


Arg Ala Val Gly Pro Ala Arg Arg Pro Leu Ser Ser Gly Ser Pro Pro 
            20                  25                  30          


Leu Glu Glu Leu Phe Thr Arg Gly Gly Pro Leu Arg Thr Phe Leu Glu 
        35                  40                  45              


Arg Gln Ala Gly Ser Glu Ala His Leu Lys Val Arg Arg Pro Glu Leu 
    50                  55                  60                  


Leu Ala Val Ile Lys Leu Leu Asn Glu Lys Glu Arg Glu Leu Arg Glu 
65                  70                  75                  80  


Thr Glu His Leu Leu His Asp Glu Asn Glu Asp Leu Arg Lys Leu Ala 
                85                  90                  95      


Glu Asn Glu Ile Thr Leu Cys Gln Lys Glu Ile Thr Gln Leu Lys His 
            100                 105                 110         


Gln Ile Ile Leu Leu Leu Val Pro Ser Glu Glu Thr Asp Glu Asn Asp 
        115                 120                 125             


Leu Ile Leu Glu Val Thr Ala Gly Val Gly Gly Gln Glu Ala Met Leu 
    130                 135                 140                 


Phe Thr Ser Glu Ile Phe Asp Met Tyr Gln Gln Tyr Ala Ala Phe Lys 
145                 150                 155                 160 


Arg Trp His Phe Glu Thr Leu Glu Tyr Phe Pro Ser Glu Leu Gly Gly 
                165                 170                 175     


Leu Arg His Ala Ser Ala Ser Ile Gly Gly Ser Glu Ala Tyr Arg His 
            180                 185                 190         


Met Lys Phe Glu Gly Gly Val His Arg Val Gln Arg Val Pro Lys Thr 
        195                 200                 205             


Glu Lys Gln Gly Arg Val His Thr Ser Thr Met Thr Val Ala Ile Leu 
    210                 215                 220                 


Pro Gln Pro Thr Glu Ile Asn Leu Val Ile Asn Pro Lys Asp Leu Arg 
225                 230                 235                 240 


Ile Asp Thr Lys Arg Ala Ser Gly Ala Gly Gly Gln His Val Asn Thr 
                245                 250                 255     


Thr Asp Ser Ala Val Arg Ile Val His Leu Pro Thr Gly Val Val Ser 
            260                 265                 270         


Glu Cys Gln Gln Glu Arg Ser Gln Leu Lys Asn Lys Glu Leu Ala Met 
        275                 280                 285             


Thr Lys Leu Arg Ala Lys Leu Tyr Ser Met His Leu Glu Glu Glu Ile 
    290                 295                 300                 


Asn Lys Arg Gln Asn Ala Arg Lys Ile Gln Ile Gly Ser Lys Gly Arg 
305                 310                 315                 320 


Ser Glu Lys Ile Arg Thr Tyr Asn Phe Pro Gln Asn Arg Val Thr Asp 
                325                 330                 335     


His Arg Ile Asn Lys Thr Leu His Asp Leu Glu Thr Phe Met Gln Gly 
            340                 345                 350         


Asp Tyr Leu Leu Asp Glu Leu Val Gln Ser Leu Lys Glu Tyr Ala Asp 
        355                 360                 365             


Tyr Glu Ser Leu Val Glu Ile Ile Ser Gln Lys Val 
    370                 375                 380 


<210> 6106
<211> 1186
<212> PRT
<213> Homo sapiens

<400> 6106
Met Cys Glu Val Met Pro Thr Ile Asn Glu Gly Asp Arg Leu Gly Pro 
1               5                   10                  15      


Pro His Gly Ala Asp Ala Asp Ala Asn Phe Glu Gln Leu Met Val Asn 
            20                  25                  30          


Met Leu Asp Glu Arg Glu Lys Leu Leu Glu Ser Leu Arg Glu Ser Gln 
        35                  40                  45              


Glu Thr Leu Ala Ala Thr Gln Ser Arg Leu Gln Asp Ala Ile His Glu 
    50                  55                  60                  


Arg Asp Gln Leu Gln Arg His Leu Asn Ser Ala Leu Pro Gln Glu Phe 
65                  70                  75                  80  


Ala Thr Leu Thr Arg Glu Leu Ser Met Cys Arg Glu Gln Leu Leu Glu 
                85                  90                  95      


Arg Glu Glu Glu Ile Ser Glu Leu Lys Ala Glu Arg Asn Asn Thr Arg 
            100                 105                 110         


Leu Leu Leu Glu His Leu Glu Cys Leu Val Ser Arg His Glu Arg Ser 
        115                 120                 125             


Leu Arg Met Thr Val Val Lys Arg Gln Ala Gln Ser Pro Ser Gly Val 
    130                 135                 140                 


Ser Ser Glu Val Glu Val Leu Lys Ala Leu Lys Ser Leu Phe Glu His 
145                 150                 155                 160 


His Lys Ala Leu Asp Glu Lys Val Arg Glu Arg Leu Arg Ala Ala Leu 
                165                 170                 175     


Glu Arg Val Thr Thr Leu Glu Glu Gln Leu Ala Gly Ala His Gln Gln 
            180                 185                 190         


Val Ser Ala Leu Gln Gln Gly Ala Gly Val Arg Asp Gly Ala Ala Glu 
        195                 200                 205             


Glu Glu Gly Thr Val Glu Leu Gly Pro Lys Arg Leu Trp Lys Glu Asp 
    210                 215                 220                 


Thr Gly Arg Val Glu Glu Leu Gln Glu Leu Leu Glu Lys Gln Asn Phe 
225                 230                 235                 240 


Glu Leu Ser Gln Ala Arg Glu Arg Leu Val Thr Leu Thr Thr Thr Val 
                245                 250                 255     


Thr Glu Leu Glu Glu Asp Leu Gly Thr Ala Arg Arg Asp Leu Ile Lys 
            260                 265                 270         


Ser Glu Glu Leu Ser Ser Lys His Gln Arg Asp Leu Arg Glu Ala Leu 
        275                 280                 285             


Ala Gln Lys Glu Asp Met Glu Glu Arg Ile Thr Thr Leu Glu Lys Arg 
    290                 295                 300                 


Tyr Leu Ala Ala Gln Arg Glu Ala Thr Ser Ile His Asp Leu Asn Asp 
305                 310                 315                 320 


Lys Leu Glu Asn Glu Leu Ala Asn Lys Glu Ser Leu His Arg Gln Cys 
                325                 330                 335     


Glu Glu Lys Ala Arg His Leu Gln Glu Leu Leu Glu Val Ala Glu Gln 
            340                 345                 350         


Lys Leu Gln Gln Thr Met Arg Lys Ala Glu Thr Leu Pro Glu Val Glu 
        355                 360                 365             


Ala Glu Leu Ala Gln Arg Ile Ala Ala Leu Thr Lys Ala Glu Glu Arg 
    370                 375                 380                 


His Gly Asn Ile Glu Glu His Leu Arg Gln Leu Glu Gly Gln Leu Glu 
385                 390                 395                 400 


Glu Lys Asn Gln Glu Leu Ala Arg Val Arg Gln Arg Glu Lys Met Asn 
                405                 410                 415     


Glu Asp His Asn Lys Arg Leu Ser Asp Thr Val Asp Arg Leu Leu Ser 
            420                 425                 430         


Glu Ser Asn Glu Arg Leu Gln Leu His Leu Lys Glu Arg Met Ala Ala 
        435                 440                 445             


Leu Glu Glu Lys Gly Arg Leu Ser Glu Glu Ile Glu Lys Leu Arg Gln 
    450                 455                 460                 


Glu Val Asp Gln Leu Lys Gly Arg Gly Gly Pro Phe Val Asp Gly Val 
465                 470                 475                 480 


His Ser Arg Ser His Met Gly Ser Ala Ala Asp Val Arg Phe Ser Leu 
                485                 490                 495     


Gly Thr Thr Thr His Ala Pro Pro Gly Val His Arg Arg Tyr Ser Ala 
            500                 505                 510         


Leu Arg Glu Glu Ser Ala Lys Asp Trp Glu Thr Ser Pro Leu Pro Gly 
        515                 520                 525             


Met Leu Ala Pro Ala Ala Gly Pro Ala Phe Asp Ser Asp Pro Glu Ile 
    530                 535                 540                 


Ser Asp Val Asp Glu Asp Glu Pro Gly Gly Leu Val Gly Ser Ala Asp 
545                 550                 555                 560 


Val Val Ser Pro Ser Gly His Ser Asp Ala Gln Thr Leu Ala Met Met 
                565                 570                 575     


Leu Gln Glu Gln Leu Asp Ala Ile Asn Glu Glu Ile Arg Met Ile Gln 
            580                 585                 590         


Glu Glu Lys Glu Ser Thr Glu Leu Arg Ala Glu Glu Ile Glu Thr Arg 
        595                 600                 605             


Val Thr Ser Gly Ser Met Glu Ala Leu Asn Leu Lys Gln Leu Arg Lys 
    610                 615                 620                 


Arg Gly Ser Ile Pro Thr Ser Leu Thr Ala Leu Ser Leu Ala Ser Ala 
625                 630                 635                 640 


Ser Pro Pro Leu Ser Gly Arg Ser Thr Pro Lys Leu Thr Ser Arg Ser 
                645                 650                 655     


Ala Ala Gln Asp Leu Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp 
            660                 665                 670         


Leu Arg Lys His Arg Arg Lys Leu Leu Ser Pro Val Ser Arg Glu Glu 
        675                 680                 685             


Asn Arg Glu Asp Lys Ala Thr Ile Lys Cys Glu Thr Ser Pro Pro Ser 
    690                 695                 700                 


Ser Pro Arg Thr Leu Arg Leu Glu Lys Leu Gly His Pro Ala Leu Ser 
705                 710                 715                 720 


Gln Glu Glu Gly Lys Ser Ala Leu Glu Asp Gln Gly Ser Asn Pro Ser 
                725                 730                 735     


Ser Ser Asn Ser Ser Gln Asp Ser Leu His Lys Gly Ala Lys Arg Lys 
            740                 745                 750         


Gly Ile Lys Ser Ser Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Gly 
        755                 760                 765             


Arg Leu Ile Gln Leu Ser Arg Asp Gly Ala Thr Gly His Val Leu Leu 
    770                 775                 780                 


Thr Asp Ser Glu Phe Ser Met Gln Glu Pro Met Val Pro Ala Lys Leu 
785                 790                 795                 800 


Gly Thr Gln Ala Glu Lys Asp Arg Arg Leu Lys Lys Lys His Gln Leu 
                805                 810                 815     


Leu Glu Asp Ala Arg Arg Lys Gly Met Pro Phe Ala Gln Trp Asp Gly 
            820                 825                 830         


Pro Thr Val Val Ser Trp Leu Glu Leu Trp Val Gly Met Pro Ala Trp 
        835                 840                 845             


Tyr Val Ala Ala Cys Arg Ala Asn Val Lys Ser Gly Ala Ile Met Ser 
    850                 855                 860                 


Ala Leu Ser Asp Thr Glu Ile Gln Arg Glu Ile Gly Ile Ser Asn Ala 
865                 870                 875                 880 


Leu His Arg Leu Lys Leu Arg Leu Ala Ile Gln Glu Met Val Ser Leu 
                885                 890                 895     


Thr Ser Pro Ser Ala Pro Pro Thr Ser Arg Thr Ser Ser Gly Asn Val 
            900                 905                 910         


Trp Val Thr His Glu Glu Met Glu Thr Leu Glu Thr Ser Thr Lys Thr 
        915                 920                 925             


Asp Ser Glu Glu Gly Ser Trp Ala Gln Thr Leu Ala Tyr Gly Asp Met 
    930                 935                 940                 


Asn His Glu Trp Ile Gly Asn Glu Trp Leu Pro Ser Leu Gly Leu Pro 
945                 950                 955                 960 


Gln Tyr Arg Ser Tyr Phe Met Glu Cys Leu Val Asp Ala Arg Met Leu 
                965                 970                 975     


Asp His Leu Thr Lys Lys Asp Leu Arg Val His Leu Lys Met Val Asp 
            980                 985                 990         


Ser Phe His Arg Thr Ser Leu Gln  Tyr Gly Ile Met Cys  Leu Lys Arg 
        995                 1000                 1005             


Leu Asn  Tyr Asp Arg Lys Glu  Leu Glu Lys Arg Arg  Glu Glu Ser 
    1010                 1015                 1020             


Gln His  Glu Ile Lys Asp Val  Leu Val Trp Thr Asn  Asp Gln Val 
    1025                 1030                 1035             


Val His  Trp Val Gln Ser Ile  Gly Leu Arg Asp Tyr  Ala Gly Asn 
    1040                 1045                 1050             


Leu His  Glu Ser Gly Val His  Gly Ala Leu Leu Ala  Leu Asp Glu 
    1055                 1060                 1065             


Asn Phe  Asp His Asn Thr Leu  Ala Leu Ile Leu Gln  Ile Pro Thr 
    1070                 1075                 1080             


Gln Asn  Thr Gln Ala Arg Gln  Val Met Glu Arg Glu  Phe Asn Asn 
    1085                 1090                 1095             


Leu Leu  Ala Leu Gly Thr Asp  Arg Lys Leu Asp Asp  Gly Asp Asp 
    1100                 1105                 1110             


Lys Val  Phe Arg Arg Ala Pro  Ser Trp Arg Lys Arg  Phe Arg Pro 
    1115                 1120                 1125             


Arg Glu  His His Gly Arg Gly  Gly Met Leu Ser Ala  Ser Ala Glu 
    1130                 1135                 1140             


Thr Leu  Pro Ala Gly Phe Arg  Val Ser Thr Leu Gly  Thr Leu Gln 
    1145                 1150                 1155             


Pro Pro  Pro Ala Pro Pro Lys  Lys Ile Met Pro Glu  Ala His Ser 
    1160                 1165                 1170             


His Tyr  Leu Tyr Gly His Met  Leu Ser Ala Phe Arg  Asp 
    1175                 1180                 1185     


<210> 6107
<211> 600
<212> PRT
<213> Homo sapiens

<400> 6107
Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Leu Met 
65                  70                  75                  80  


Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val Glu Thr Lys Thr 
                85                  90                  95      


Asp Ala Lys Asn Gly Glu Glu Arg Gly Arg Asp Ala Ser Lys Lys Ala 
            100                 105                 110         


Leu Gly Pro Arg Arg Asp Ser Asp Leu Gly Lys Glu Pro Lys Arg Gly 
        115                 120                 125             


Gly Leu Lys Lys Ser Phe Ser Arg Asp Arg Asp Glu Ala Gly Gly Lys 
    130                 135                 140                 


Ser Gly Glu Lys Pro Lys Glu Glu Lys Ile Ile Arg Gly Ile Asp Lys 
145                 150                 155                 160 


Gly Arg Val Arg Ala Ala Val Asp Lys Lys Glu Ala Gly Lys Asp Gly 
                165                 170                 175     


Arg Gly Glu Glu Arg Ala Val Ala Thr Lys Lys Glu Glu Glu Lys Lys 
            180                 185                 190         


Gly Ser Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp Lys Lys Arg 
        195                 200                 205             


Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys 
    210                 215                 220                 


Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys 
225                 230                 235                 240 


Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys 
                245                 250                 255     


Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys 
            260                 265                 270         


Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr 
        275                 280                 285             


Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu 
    290                 295                 300                 


Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu 
305                 310                 315                 320 


Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn 
                325                 330                 335     


Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr 
            340                 345                 350         


Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn 
        355                 360                 365             


Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys 
    370                 375                 380                 


Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr 
385                 390                 395                 400 


Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr 
                405                 410                 415     


Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys 
            420                 425                 430         


Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu 
        435                 440                 445             


Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr 
    450                 455                 460                 


Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln 
465                 470                 475                 480 


Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu 
                485                 490                 495     


Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser 
            500                 505                 510         


Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly 
        515                 520                 525             


Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro 
    530                 535                 540                 


Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg 
545                 550                 555                 560 


Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp 
                565                 570                 575     


Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys 
            580                 585                 590         


Val Glu Val Pro Lys Leu Leu Gln 
        595                 600 


<210> 6108
<211> 275
<212> PRT
<213> Homo sapiens

<400> 6108
Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro 
1               5                   10                  15      


Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala Ser 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly Leu Leu Gly 
        35                  40                  45              


Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys Ser Pro Gly 
    50                  55                  60                  


Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu Val Ile Gln 
65                  70                  75                  80  


Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn Pro Ala Phe 
                85                  90                  95      


Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn Leu Met Gln 
            100                 105                 110         


Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile Thr His 
        115                 120                 125             


Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp Glu Ile 
    130                 135                 140                 


Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu Gln Ile 
145                 150                 155                 160 


Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu Val Arg 
            180                 185                 190         


Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala Val Ile 
        195                 200                 205             


Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp Gly Lys Lys Ile Leu 
    210                 215                 220                 


Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu Gln Cys Leu Phe 
225                 230                 235                 240 


Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp Lys Thr Arg Gln 
                245                 250                 255     


Leu Gln Ser Lys Thr Glu Ser Arg Ser Val Thr Arg Leu Glu Cys Arg 
            260                 265                 270         


Arg Val Ile 
        275 


<210> 6109
<211> 332
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6109
Xaa Gly Arg Glu Gly Leu Leu Gly Gln Arg Arg Pro Gln Asp Gly Gln 
1               5                   10                  15      


Ala Arg Ser Ser Cys Ser Pro Gly Gly Arg Thr Pro Ala Ala Arg Asp 
            20                  25                  30          


Ser Ile Val Arg Glu Val Ile Gln Asn Ser Lys Glu Val Leu Ser Leu 
        35                  40                  45              


Leu Gln Glu Lys Asn Pro Ala Phe Lys Pro Val Leu Ala Ile Ile Gln 
    50                  55                  60                  


Ala Gly Asp Asp Asn Leu Met Gln Glu Ile Asn Gln Asn Leu Ala Glu 
65                  70                  75                  80  


Glu Ala Gly Leu Asn Ile Thr His Ile Cys Leu Pro Pro Asp Ser Ser 
                85                  90                  95      


Glu Ala Glu Ile Ile Asp Glu Ile Leu Lys Ile Asn Glu Asp Thr Arg 
            100                 105                 110         


Val His Gly Leu Ala Leu Gln Ile Ser Glu Asn Leu Phe Ser Asn Lys 
        115                 120                 125             


Val Leu Asn Ala Leu Lys Pro Glu Lys Asp Val Asp Gly Val Thr Asp 
    130                 135                 140                 


Ile Asn Leu Gly Lys Leu Val Arg Gly Asp Ala His Glu Cys Phe Val 
145                 150                 155                 160 


Ser Pro Val Ala Lys Ala Val Ile Glu Leu Leu Glu Lys Ser Val Gly 
                165                 170                 175     


Val Asn Leu Asp Gly Lys Lys Ile Leu Val Val Gly Ala His Gly Ser 
            180                 185                 190         


Leu Glu Ala Ala Leu Gln Cys Leu Phe Gln Arg Lys Gly Ser Met Thr 
        195                 200                 205             


Met Ser Ile Gln Trp Lys Thr Arg Gln Leu Gln Ser Lys Leu His Glu 
    210                 215                 220                 


Ala Asp Ile Val Val Leu Gly Ser Pro Lys Pro Glu Glu Ile Pro Leu 
225                 230                 235                 240 


Thr Trp Ile Gln Pro Gly Thr Thr Val Leu Asn Cys Ser His Asp Phe 
                245                 250                 255     


Leu Ser Gly Lys Val Gly Cys Gly Ser Pro Arg Ile His Phe Gly Gly 
            260                 265                 270         


Leu Ile Glu Glu Asp Asp Val Ile Leu Leu Ala Ala Ala Leu Arg Ile 
        275                 280                 285             


Gln Asn Met Val Ser Ser Gly Arg Arg Trp Leu Arg Glu Gln Gln His 
    290                 295                 300                 


Arg Arg Trp Arg Leu His Cys Leu Lys Leu Gln Pro Leu Ser Pro Val 
305                 310                 315                 320 


Pro Ser Asp Ile Glu Ile Ser Arg Gly Gln Thr Pro 
                325                 330         


<210> 6110
<211> 978
<212> PRT
<213> Homo sapiens

<400> 6110
Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro 
1               5                   10                  15      


Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala Ser 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly Leu Leu Gly 
        35                  40                  45              


Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys Ser Pro Gly 
    50                  55                  60                  


Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu Val Ile Gln 
65                  70                  75                  80  


Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn Pro Ala Phe 
                85                  90                  95      


Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn Leu Met Gln 
            100                 105                 110         


Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile Thr His 
        115                 120                 125             


Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp Glu Ile 
    130                 135                 140                 


Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu Gln Ile 
145                 150                 155                 160 


Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu Val Arg 
            180                 185                 190         


Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala Val Ile 
        195                 200                 205             


Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp Gly Lys Lys Ile Leu 
    210                 215                 220                 


Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu Gln Cys Leu Phe 
225                 230                 235                 240 


Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp Lys Thr Arg Gln 
                245                 250                 255     


Leu Gln Ser Lys Leu His Glu Ala Asp Ile Val Val Leu Gly Ser Pro 
            260                 265                 270         


Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile Gln Pro Gly Thr Thr Val 
        275                 280                 285             


Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys Val Gly Cys Gly Ser 
    290                 295                 300                 


Pro Arg Ile His Phe Gly Gly Leu Ile Glu Glu Asp Asp Val Ile Leu 
305                 310                 315                 320 


Leu Ala Ala Ala Leu Arg Ile Gln Asn Met Val Ser Ser Gly Arg Arg 
                325                 330                 335     


Trp Leu Arg Glu Gln Gln His Arg Arg Trp Arg Leu His Cys Leu Lys 
            340                 345                 350         


Leu Gln Pro Leu Ser Pro Val Pro Ser Asp Ile Glu Ile Ser Arg Gly 
        355                 360                 365             


Gln Thr Pro Lys Ala Val Asp Val Leu Ala Lys Glu Ile Gly Leu Leu 
    370                 375                 380                 


Ala Asp Glu Ile Glu Ile Tyr Gly Lys Ser Lys Ala Lys Val Arg Leu 
385                 390                 395                 400 


Ser Val Leu Glu Arg Leu Lys Asp Gln Ala Asp Gly Lys Tyr Val Leu 
                405                 410                 415     


Val Ala Gly Ile Thr Pro Thr Pro Leu Gly Glu Gly Lys Ser Thr Val 
            420                 425                 430         


Thr Ile Gly Leu Val Gln Ala Leu Thr Ala His Leu Asn Val Asn Ser 
        435                 440                 445             


Phe Ala Cys Leu Arg Gln Pro Ser Gln Gly Pro Thr Phe Gly Val Lys 
    450                 455                 460                 


Gly Gly Ala Ala Gly Gly Gly Tyr Ala Gln Val Ile Pro Met Glu Glu 
465                 470                 475                 480 


Phe Asn Leu His Leu Thr Gly Asp Ile His Ala Ile Thr Ala Ala Asn 
                485                 490                 495     


Asn Leu Leu Ala Ala Ala Ile Asp Thr Arg Ile Leu His Glu Asn Thr 
            500                 505                 510         


Gln Thr Asp Lys Ala Leu Tyr Asn Arg Leu Val Pro Leu Val Asn Gly 
        515                 520                 525             


Val Arg Glu Phe Ser Glu Ile Gln Leu Ala Arg Leu Lys Lys Leu Gly 
    530                 535                 540                 


Ile Asn Lys Thr Asp Pro Ser Thr Leu Thr Glu Glu Glu Val Ser Lys 
545                 550                 555                 560 


Phe Ala Arg Leu Asp Ile Asp Pro Ser Thr Ile Thr Trp Gln Arg Val 
                565                 570                 575     


Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile Thr Ile Gly Gln Gly 
            580                 585                 590         


Asn Thr Glu Lys Gly His Tyr Arg Gln Ala Gln Phe Asp Ile Ala Val 
        595                 600                 605             


Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr Asp Ser Leu Ala Asp 
    610                 615                 620                 


Met Lys Ala Arg Leu Gly Arg Met Val Val Ala Ser Asp Lys Ser Gly 
625                 630                 635                 640 


Gln Pro Val Thr Ala Asp Asp Leu Gly Val Thr Gly Ala Leu Thr Val 
                645                 650                 655     


Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met Gln Thr Leu Glu Gly 
            660                 665                 670         


Thr Pro Val Phe Val His Ala Gly Pro Phe Ala Asn Ile Ala His Gly 
        675                 680                 685             


Asn Ser Ser Val Leu Ala Asp Lys Ile Ala Leu Lys Leu Val Gly Glu 
    690                 695                 700                 


Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly Ala Asp Ile Gly Met 
705                 710                 715                 720 


Glu Lys Phe Phe Asn Ile Lys Cys Arg Ala Ser Gly Leu Val Pro Asn 
                725                 730                 735     


Val Val Val Leu Val Ala Thr Val Arg Ala Leu Lys Met His Gly Gly 
            740                 745                 750         


Gly Pro Ser Val Thr Ala Gly Val Pro Leu Lys Lys Glu Tyr Thr Glu 
        755                 760                 765             


Glu Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys Gln 
    770                 775                 780                 


Ile Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val Val Ala Leu Asn 
785                 790                 795                 800 


Val Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu Leu 
                805                 810                 815     


Ala Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp Ser 
            820                 825                 830         


Val Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu Ala 
        835                 840                 845             


Ala Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Val Pro 
    850                 855                 860                 


Ile Val Asp Lys Ile Arg Thr Ile Ala Gln Ala Val Tyr Gly Ala Lys 
865                 870                 875                 880 


Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys Ile Asp Arg Tyr Thr 
                885                 890                 895     


Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala Lys Thr His Leu 
            900                 905                 910         


Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro Arg Asp Phe Ile 
        915                 920                 925             


Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile Tyr 
    930                 935                 940                 


Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly Leu Pro Thr Arg Pro 
945                 950                 955                 960 


Cys Phe Tyr Asp Ile Asp Leu Asp Thr Glu Thr Glu Gln Val Lys Gly 
                965                 970                 975     


Leu Phe 
        


<210> 6111
<211> 135
<212> PRT
<213> Homo sapiens

<400> 6111
Met Ile Pro Asn Gly Tyr Leu Met Phe Glu Asp Glu Asn Phe Ile Glu 
1               5                   10                  15      


Ser Ser Val Ala Lys Leu Asn Ala Leu Arg Lys Ser Gly Gln Phe Cys 
            20                  25                  30          


Asp Val Arg Leu Gln Val Cys Gly His Glu Met Leu Ala His Arg Ala 
        35                  40                  45              


Val Leu Ala Cys Cys Ser Pro Tyr Leu Phe Glu Ile Phe Asn Ser Asp 
    50                  55                  60                  


Ser Asp Pro His Gly Ile Ser His Val Lys Phe Asp Asp Leu Asn Pro 
65                  70                  75                  80  


Glu Ala Val Glu Val Leu Leu Asn Tyr Ala Tyr Thr Ala Gln Leu Lys 
                85                  90                  95      


Ala Asp Lys Glu Leu Val Lys Asp Val Tyr Ser Ala Ala Lys Lys Leu 
            100                 105                 110         


Lys Met Asp Arg Val Lys Gln His Leu Leu Tyr Phe Cys Leu His Ser 
        115                 120                 125             


Thr Ser Thr Ser Ser Leu Leu 
    130                 135 


<210> 6112
<211> 642
<212> PRT
<213> Homo sapiens

<400> 6112
Met Ile Pro Asn Gly Tyr Leu Met Phe Glu Asp Glu Asn Phe Ile Glu 
1               5                   10                  15      


Ser Ser Val Ala Lys Leu Asn Ala Leu Arg Lys Ser Gly Gln Phe Cys 
            20                  25                  30          


Asp Val Arg Leu Gln Val Cys Gly His Glu Met Leu Ala His Arg Ala 
        35                  40                  45              


Val Leu Ala Cys Cys Ser Pro Tyr Leu Phe Glu Ile Phe Asn Ser Asp 
    50                  55                  60                  


Ser Asp Pro His Gly Ile Ser His Val Lys Phe Asp Asp Leu Asn Pro 
65                  70                  75                  80  


Glu Ala Val Glu Val Leu Leu Asn Tyr Ala Tyr Thr Ala Gln Leu Lys 
                85                  90                  95      


Ala Asp Lys Glu Leu Val Lys Asp Val Tyr Ser Ala Ala Lys Lys Leu 
            100                 105                 110         


Lys Met Asp Arg Val Lys Gln Val Cys Gly Asp Tyr Leu Leu Ser Arg 
        115                 120                 125             


Met Asp Val Thr Ser Cys Ile Ser Tyr Arg Asn Phe Ala Ser Cys Met 
    130                 135                 140                 


Gly Asp Ser Arg Leu Leu Asn Lys Val Asp Ala Tyr Ile Gln Glu His 
145                 150                 155                 160 


Leu Leu Gln Ile Ser Glu Glu Glu Glu Phe Leu Lys Leu Pro Arg Leu 
                165                 170                 175     


Lys Leu Glu Val Met Leu Glu Asp Asn Val Cys Leu Pro Ser Asn Gly 
            180                 185                 190         


Lys Leu Tyr Thr Lys Val Ile Asn Trp Val Gln Arg Ser Ile Trp Glu 
        195                 200                 205             


Asn Gly Asp Ser Leu Glu Glu Leu Met Glu Glu Val Gln Thr Leu Tyr 
    210                 215                 220                 


Tyr Ser Ala Asp His Lys Leu Leu Asp Gly Asn Leu Leu Asp Gly Gln 
225                 230                 235                 240 


Ala Glu Val Phe Gly Ser Asp Asp Asp His Ile Gln Phe Val Gln Lys 
                245                 250                 255     


Lys Pro Pro Arg Glu Asn Gly His Lys Gln Ile Ser Ser Ser Ser Thr 
            260                 265                 270         


Gly Cys Leu Ser Ser Pro Asn Ala Thr Val Gln Ser Pro Lys His Glu 
        275                 280                 285             


Trp Lys Ile Val Ala Ser Glu Lys Thr Ser Asn Asn Thr Tyr Leu Cys 
    290                 295                 300                 


Leu Ala Val Leu Asp Gly Ile Phe Cys Val Ile Phe Leu His Gly Arg 
305                 310                 315                 320 


Asn Ser Pro Gln Ser Ser Pro Thr Ser Thr Pro Lys Leu Ser Lys Ser 
                325                 330                 335     


Leu Ser Phe Glu Met Gln Gln Asp Glu Leu Ile Glu Lys Pro Met Ser 
            340                 345                 350         


Pro Met Gln Tyr Ala Arg Ser Gly Leu Gly Thr Ala Glu Met Asn Gly 
        355                 360                 365             


Lys Leu Ile Ala Ala Gly Gly Tyr Asn Arg Glu Glu Cys Leu Arg Thr 
    370                 375                 380                 


Val Glu Cys Tyr Asn Pro His Thr Asp His Trp Ser Phe Leu Ala Pro 
385                 390                 395                 400 


Met Arg Thr Pro Arg Ala Arg Phe Gln Met Ala Val Leu Met Gly Gln 
                405                 410                 415     


Leu Tyr Val Val Gly Gly Ser Asn Gly His Ser Asp Asp Leu Ser Cys 
            420                 425                 430         


Gly Glu Met Tyr Asp Ser Asn Ile Asp Asp Trp Ile Pro Val Pro Glu 
        435                 440                 445             


Leu Arg Thr Asn Arg Cys Asn Ala Gly Val Cys Ala Leu Asn Gly Lys 
    450                 455                 460                 


Leu Tyr Ile Val Gly Gly Ser Asp Pro Tyr Gly Gln Lys Gly Leu Lys 
465                 470                 475                 480 


Asn Cys Asp Val Phe Asp Pro Val Thr Lys Leu Trp Thr Ser Cys Ala 
                485                 490                 495     


Pro Leu Asn Ile Arg Arg His Gln Ser Ala Val Cys Glu Leu Gly Gly 
            500                 505                 510         


Tyr Leu Tyr Ile Ile Gly Gly Ala Glu Ser Trp Asn Cys Leu Asn Thr 
        515                 520                 525             


Val Glu Arg Tyr Asn Pro Glu Asn Asn Thr Trp Thr Leu Ile Ala Pro 
    530                 535                 540                 


Met Asn Val Ala Arg Arg Gly Ala Gly Val Ala Val Leu Asn Gly Lys 
545                 550                 555                 560 


Leu Phe Val Cys Gly Gly Phe Asp Gly Ser His Ala Ile Ser Cys Val 
                565                 570                 575     


Glu Met Tyr Asp Pro Thr Arg Asn Glu Trp Lys Met Met Gly Asn Met 
            580                 585                 590         


Thr Ser Pro Arg Ser Asn Ala Gly Ile Ala Thr Val Gly Asn Thr Ile 
        595                 600                 605             


Tyr Ala Val Gly Gly Phe Asp Gly Asn Glu Phe Leu Asn Thr Val Glu 
    610                 615                 620                 


Val Tyr Asn Leu Glu Ser Asn Glu Trp Ser Pro Tyr Thr Lys Ile Phe 
625                 630                 635                 640 


Gln Phe 
        


<210> 6113
<211> 135
<212> PRT
<213> Homo sapiens

<400> 6113
Met Ser Lys Asn Thr Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg Gln 
        35                  40                  45              


Gly Asn Met Thr Ala Ala Leu Gln Ala Ala Leu Lys Asn Pro Pro Ile 
    50                  55                  60                  


Asn Thr Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser Ile Val Leu 
65                  70                  75                  80  


Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys Ala Val Gln 
                85                  90                  95      


Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr Ile Tyr Lys 
            100                 105                 110         


Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu Leu Gln Trp 
        115                 120                 125             


His Glu Lys Val Pro Leu Val 
    130                 135 


<210> 6114
<211> 282
<212> PRT
<213> Homo sapiens

<400> 6114
Met Ala Ser Ser Phe Leu Pro Ala Gly Ala Ile Thr Gly Asp Ser Gly 
1               5                   10                  15      


Gly Glu Leu Ser Ser Gly Asp Asp Ser Gly Glu Val Glu Phe Pro His 
            20                  25                  30          


Ser Pro Glu Ile Glu Glu Thr Ser Cys Leu Ala Glu Leu Phe Glu Lys 
        35                  40                  45              


Ala Ala Ala His Leu Gln Gly Leu Ile Gln Val Ala Ser Arg Glu Gln 
    50                  55                  60                  


Leu Leu Tyr Leu Tyr Ala Arg Tyr Lys Gln Val Lys Val Gly Asn Cys 
65                  70                  75                  80  


Asn Thr Pro Lys Pro Ser Phe Phe Asp Phe Glu Gly Lys Gln Lys Trp 
                85                  90                  95      


Glu Ala Trp Lys Ala Leu Gly Asp Ser Ser Pro Ser Gln Ala Met Gln 
            100                 105                 110         


Glu Tyr Ile Ala Val Val Lys Lys Leu Asp Pro Gly Trp Asn Pro Gln 
        115                 120                 125             


Ile Pro Glu Lys Lys Gly Lys Glu Ala Asn Thr Gly Phe Gly Gly Pro 
    130                 135                 140                 


Val Ile Ser Ser Leu Tyr His Glu Glu Thr Ile Arg Glu Glu Asp Lys 
145                 150                 155                 160 


Asn Ile Phe Asp Tyr Cys Arg Glu Asn Asn Ile Asp His Ile Thr Lys 
                165                 170                 175     


Ala Ile Lys Ser Lys Asn Val Asp Val Asn Val Lys Asp Glu Glu Gly 
            180                 185                 190         


Arg Ala Leu Leu His Trp Ala Cys Asp Arg Gly His Lys Glu Leu Val 
        195                 200                 205             


Thr Val Leu Leu Gln His Arg Ala Asp Ile Asn Cys Gln Asp Asn Glu 
    210                 215                 220                 


Gly Gln Thr Ala Leu His Tyr Ala Ser Ala Cys Glu Phe Leu Asp Ile 
225                 230                 235                 240 


Val Glu Leu Leu Leu Gln Ser Gly Ala Asp Pro Thr Leu Arg Asp Gln 
                245                 250                 255     


Asp Gly Cys Leu Pro Glu Glu Val Thr Gly Cys Lys Thr Val Ser Leu 
            260                 265                 270         


Val Leu Gln Arg His Thr Thr Gly Lys Ala 
        275                 280         


<210> 6115
<211> 3117
<212> PRT
<213> Homo sapiens

<400> 6115
Met Arg Ser Ser Lys Ser Lys Glu Val Pro Leu Pro Asn Pro Arg Asn 
1               5                   10                  15      


Ser Gln Ser Lys Asp Thr Val Gln Ala Asp Ile Thr Thr Ser Trp Asp 
            20                  25                  30          


Ala Leu Ser Gln Thr Lys Ala Ala Leu Arg His Ile Glu Asn Lys Leu 
        35                  40                  45              


Glu Val Ala Pro Thr Ser Thr Ala Val Cys Asp Ser Val Met Asp Thr 
    50                  55                  60                  


Lys Lys Ser Ser Thr Ser Ala Thr Arg Lys Ile Ser Arg Lys Asp Gly 
65                  70                  75                  80  


Arg Tyr Leu Asp Asp Ser Trp Val Asn Ala Pro Ile Ser Lys Ser Thr 
                85                  90                  95      


Lys Ser Arg Lys Glu Lys Ser Arg Ser Pro Leu Arg Ala Thr Thr Leu 
            100                 105                 110         


Glu Ser Asn Val Lys Lys Asn Asn Arg Val Glu Phe Arg Glu Pro Leu 
        115                 120                 125             


Val Ser Tyr Arg Glu Ile His Gly Ala Pro Ser Asn Phe Ser Ser Ser 
    130                 135                 140                 


His Leu Glu Ser Lys His Val Tyr Cys Val Asp Val Asn Glu Glu Lys 
145                 150                 155                 160 


Thr Glu Ser Gly Asn Trp Met Ile Gly Ser Arg Glu Glu Arg Asn Ile 
                165                 170                 175     


Arg Ser Cys Asp Phe Glu Ser Ser Gln Ser Ser Val Ile Asn Asp Thr 
            180                 185                 190         


Val Val Arg Phe Leu Asn Asp Arg Pro Ala Ile Asp Ala Leu Gln Asn 
        195                 200                 205             


Ser Glu Cys Leu Ile Arg Met Gly Ala Ser Met Arg Thr Glu Glu Glu 
    210                 215                 220                 


Met Pro Asn Arg Thr Lys Gly Ser Glu Asn Asn Leu Lys Leu Ser Val 
225                 230                 235                 240 


Asn Asn Met Ala His Asp Thr Asp Pro Lys Ala Leu Arg Leu Thr Asp 
                245                 250                 255     


Ser Ser Pro Ser Ser Thr Ser Thr Ser Asn Ser Gln Arg Leu Asp Ile 
            260                 265                 270         


Leu Lys Arg Arg Gln His Asp Val Lys Leu Glu Lys Leu Lys Glu Arg 
        275                 280                 285             


Ile Arg Lys Gln Trp Glu His Ser Glu Glu Thr Asn Gly Arg Gly Gln 
    290                 295                 300                 


Lys Leu Gly His Ile Asp His Pro Val Met Val Val Asn Val Asp Asn 
305                 310                 315                 320 


Ser Val Thr Ala Lys Val Arg Lys Val Ala Thr Ala Pro Pro Ala Pro 
                325                 330                 335     


Ala Tyr Lys Gly Phe Asn Pro Ser Glu Thr Lys Ile Arg Thr Pro Asp 
            340                 345                 350         


Gly Lys Val Trp Gln Glu Ala Glu Phe Gln Asn Met Ser Arg Glu Leu 
        355                 360                 365             


Tyr Arg Asp Leu Ala Leu His Phe Ala Asp Asp Ile Ser Ile Lys Glu 
    370                 375                 380                 


Lys Pro Ala Glu Lys Ser Lys Glu Lys Lys Val Val Lys Pro Val Arg 
385                 390                 395                 400 


Lys Val Gln Lys Val Ala Gln Leu Ser Ser Thr Glu Cys Arg Thr Gly 
                405                 410                 415     


Ser Ser His Leu Ile Ser Thr Ser Ser Trp Arg Asp Gly Gln Lys Leu 
            420                 425                 430         


Val Lys Lys Ile Leu Gly Pro Ala Pro Arg Met Glu Pro Lys Glu Gln 
        435                 440                 445             


Arg Thr Ala Ser Ser Asp Arg Gly Gly Arg Glu Arg Thr Ala Lys Ser 
    450                 455                 460                 


Gly Gly His Ile Gly Arg Ala Glu Ser Asp Pro Arg Leu Asp Val Leu 
465                 470                 475                 480 


His Arg His Leu Gln Arg Asn Ser Glu Arg Ser Arg Ser Lys Ser Arg 
                485                 490                 495     


Ser Glu Asn Asn Ile Lys Lys Leu Ala Ser Ser Leu Pro Asp Asn Lys 
            500                 505                 510         


Gln Glu Glu Asn Thr Ala Leu Asn Lys Asp Phe Leu Pro Ile Glu Ile 
        515                 520                 525             


Arg Gly Ile Leu Asp Asp Leu Gln Leu Asp Ser Thr Ala His Thr Ala 
    530                 535                 540                 


Lys Gln Asp Thr Val Glu Leu Gln Asn Gln Lys Ser Ser Ala Pro Val 
545                 550                 555                 560 


His Ala Pro Arg Ser His Ser Pro Val Lys Arg Lys Pro Asp Lys Ile 
                565                 570                 575     


Thr Ala Asn Glu Asp Pro Pro Val Ile Ser Lys Arg Arg His Tyr Asp 
            580                 585                 590         


Thr Asp Glu Val Arg Gln Tyr Ile Val Arg Gln Gln Glu Glu Arg Lys 
        595                 600                 605             


Arg Lys Gln Asn Glu Glu Lys Lys Ala Gln Lys Glu Ala Thr Glu Gln 
    610                 615                 620                 


Lys Asn Lys Arg Leu Gln Glu Leu Tyr Arg Lys Gln Lys Glu Ala Phe 
625                 630                 635                 640 


Thr Lys Val Lys Asn Val Pro Pro Ser Glu Pro Ser Ala Thr Arg Arg 
                645                 650                 655     


Leu Gln Glu Thr Tyr Ser Lys Leu Leu Leu Glu Lys Thr Leu Leu Glu 
            660                 665                 670         


Glu Pro Ser His Gln His Val Thr Gln Glu Thr Gln Ala Lys Pro Gly 
        675                 680                 685             


Tyr Gln Pro Ser Gly Glu Ser Asp Lys Glu Asn Lys Val Gln Glu Arg 
    690                 695                 700                 


Pro Pro Ser Ala Ser Ser Ser Ser Asp Met Ser Leu Ser Glu Pro Pro 
705                 710                 715                 720 


Gln Pro Leu Ala Arg Lys Asp Leu Met Glu Ser Thr Trp Met Gln Pro 
                725                 730                 735     


Glu Arg Leu Ser Pro Gln Val His His Ser Gln Pro Gln Pro Phe Ala 
            740                 745                 750         


Gly Thr Ala Gly Ser Leu Leu Ser His Leu Leu Ser Leu Glu His Val 
        755                 760                 765             


Gly Ile Leu His Lys Asp Phe Glu Ser Ile Leu Pro Thr Arg Lys Asn 
    770                 775                 780                 


His Asn Met Ala Ser Arg Pro Leu Thr Phe Thr Pro Gln Pro Tyr Val 
785                 790                 795                 800 


Thr Ser Pro Ala Ala Tyr Thr Asp Ala Leu Leu Lys Pro Ser Ala Ser 
                805                 810                 815     


Gln Tyr Lys Ser Lys Leu Asp Arg Ile Glu Ala Leu Lys Ala Thr Ala 
            820                 825                 830         


Ala Ser Leu Ser Ser Arg Ile Glu Ser Glu Ala Lys Lys Leu Ala Gly 
        835                 840                 845             


Ala Ser Ile Asn Tyr Gly Ser Ala Trp Asn Thr Glu Tyr Asp Val Gln 
    850                 855                 860                 


Gln Ala Pro Gln Glu Asp Gly Pro Trp Thr Lys Ala Val Thr Pro Pro 
865                 870                 875                 880 


Val Lys Asp Asp Asn Glu Asp Val Phe Ser Ala Arg Ile Gln Lys Met 
                885                 890                 895     


Leu Gly Ser Cys Val Ser His Ala Thr Phe Asp Asp Asp Leu Pro Gly 
            900                 905                 910         


Val Gly Asn Leu Ser Glu Phe Lys Lys Leu Pro Glu Met Ile Arg Pro 
        915                 920                 925             


Gln Ser Ala Ile Ser Ser Phe Arg Val Arg Ser Pro Gly Pro Lys Pro 
    930                 935                 940                 


Glu Gly Leu Leu Ala Gln Leu Cys Lys Arg Gln Thr Asp Ser Ser Ser 
945                 950                 955                 960 


Ser Asp Met Gln Ala Cys Ser Gln Asp Lys Ala Lys Ile Ser Leu Gly 
                965                 970                 975     


Ser Ser Ile Asp Ser Val Ser Glu Gly Pro Leu Leu Ser Glu Gly Ser 
            980                 985                 990         


Leu Ser Glu Glu Glu Gly Asp Gln  Asp Gly Gln Pro Leu  Leu Lys Val 
        995                 1000                 1005             


Ala Glu  Ile Leu Lys Glu Lys  Glu Phe Cys Pro Gly  Glu Arg Asn 
    1010                 1015                 1020             


Ser Tyr  Glu Pro Ile Lys Glu  Phe Gln Lys Glu Ala  Glu Lys Phe 
    1025                 1030                 1035             


Leu Pro  Leu Phe Gly His Ile  Gly Gly Thr Gln Ser  Lys Gly Pro 
    1040                 1045                 1050             


Trp Glu  Glu Leu Ala Lys Gly  Ser Pro His Ser Val  Ile Asn Ile 
    1055                 1060                 1065             


Phe Thr  Lys Ser Tyr Gln Leu  Tyr Gly Lys Gly Phe  Glu Asp Lys 
    1070                 1075                 1080             


Leu Asp  Arg Gly Thr Ser Thr  Ser Arg Pro Leu Asn  Ala Thr Ala 
    1085                 1090                 1095             


Thr Pro  Leu Ser Gly Val Ser  Tyr Glu Asp Asp Phe  Val Ser Ser 
    1100                 1105                 1110             


Pro Gly  Thr Gly Thr Ser Thr  Glu Lys Lys Ser Thr  Leu Glu Pro 
    1115                 1120                 1125             


His Ser  Thr Leu Ser Pro Gln  Glu Asp His Ser Asn  Arg Lys Ser 
    1130                 1135                 1140             


Ala Tyr  Asp Pro Ser Ser Val  Asp Val Thr Ser Gln  His Ser Ser 
    1145                 1150                 1155             


Gly Ala  Gln Ser Ala Ala Ser  Ser Arg Ser Ser Thr  Ser Ser Lys 
    1160                 1165                 1170             


Gly Lys  Lys Gly Lys Lys Glu  Lys Thr Glu Trp Leu  Asp Ser Phe 
    1175                 1180                 1185             


Thr Gly  Asn Val Gln Asn Ser  Leu Leu Asp Glu Glu  Lys Ala Glu 
    1190                 1195                 1200             


Arg Gly  Ser His Gln Gly Lys  Lys Ser Gly Thr Ser  Ser Lys Leu 
    1205                 1210                 1215             


Ser Val  Lys Asp Phe Glu Gln  Thr Leu Asp Thr Asp  Ser Thr Leu 
    1220                 1225                 1230             


Glu Asp  Leu Ser Gly His Ser  Val Ser Val Ser Ser  Asp Lys Gly 
    1235                 1240                 1245             


Arg Ser  Gln Lys Thr Pro Thr  Ser Pro Leu Ser Pro  Ser Ser Gln 
    1250                 1255                 1260             


Lys Ser  Leu Gln Phe Asp Val  Ala Gly Thr Ser Ser  Glu Arg Ser 
    1265                 1270                 1275             


Lys Ser  Ser Val Met Pro Pro  Thr Ile Thr Gly Phe  Lys Pro Asn 
    1280                 1285                 1290             


Ala Pro  Leu Thr Asp Leu Asn  Pro Ala Ala Ser Arg  Thr Thr Thr 
    1295                 1300                 1305             


Glu Asn  Met Ala Pro Ile Pro  Gly Ser Lys Arg Phe  Ser Pro Ala 
    1310                 1315                 1320             


Gly Leu  His His Arg Met Ala  Ala Glu Leu Ser Tyr  Leu Asn Ala 
    1325                 1330                 1335             


Ile Glu  Glu Ser Val Arg Gln  Leu Ser Asp Val Glu  Arg Val Arg 
    1340                 1345                 1350             


Gly Ile  Ser Leu Ala Gln Gln  Glu Ser Val Ser Leu  Ala Gln Ile 
    1355                 1360                 1365             


Ile Lys  Ala Gln Gln Gln Arg  His Glu Arg Asp Leu  Ala Leu Leu 
    1370                 1375                 1380             


Lys Leu  Lys Ala Glu Gln Glu  Ala Leu Glu Ser Gln  Arg Gln Leu 
    1385                 1390                 1395             


Glu Glu  Thr Arg Asn Lys Ala  Ala Gln Val His Ala  Glu Ser Leu 
    1400                 1405                 1410             


Gln Gln  Val Val Gln Ser Gln  Arg Glu Val Thr Glu  Val Leu Gln 
    1415                 1420                 1425             


Glu Ala  Thr Cys Lys Ile Ala  Ala Gln Gln Ser Glu  Thr Ala Arg 
    1430                 1435                 1440             


Leu Thr  Thr Asp Ala Ala Arg  Gln Ile Cys Glu Met  Ala Glu Leu 
    1445                 1450                 1455             


Thr Arg  Thr His Ile Ser Asp  Ala Val Val Ala Ser  Gly Ala Pro 
    1460                 1465                 1470             


Leu Ala  Ile Leu Tyr Asp His  Gln Arg Gln His Leu  Pro Asp Phe 
    1475                 1480                 1485             


Val Lys  Gln Leu Arg Thr Arg  Thr Glu Thr Asp Arg  Lys Ser Pro 
    1490                 1495                 1500             


Ser Val  Ser Leu Ser Gln Ser  Lys Glu Gly Thr Leu  Asp Ser Lys 
    1505                 1510                 1515             


His Gln  Lys Tyr Ser Ala Ser  Tyr Asp Ser Tyr Ser  Glu Ser Ser 
    1520                 1525                 1530             


Gly Tyr  Lys Asn His Asp Arg  Arg Ser Ser Ser Gly  Ser Ser Arg 
    1535                 1540                 1545             


Gln Glu  Ser Pro Ser Val Pro  Ser Cys Lys Glu Asn  Glu Lys Lys 
    1550                 1555                 1560             


Leu Asn  Gly Glu Lys Ile Glu  Ser Ser Ile Asp Glu  Gln Val Gln 
    1565                 1570                 1575             


Thr Ala  Ala Asp Asp Ser Leu  Arg Ser Asp Ser Val  Pro Ser Leu 
    1580                 1585                 1590             


Pro Asp  Glu Lys Asp Ser Thr  Ser Ile Ala Thr Glu  Tyr Ser Leu 
    1595                 1600                 1605             


Lys Phe  Asp Glu Ser Met Thr  Glu Asp Glu Ile Glu  Glu Gln Ser 
    1610                 1615                 1620             


Phe Arg  Ser Leu Leu Pro Ser  Glu Ser His Arg Arg  Phe Asn Met 
    1625                 1630                 1635             


Glu Lys  Arg Arg Gly His His  Asp Asp Ser Asp Glu  Glu Ala Ser 
    1640                 1645                 1650             


Pro Glu  Lys Thr Thr Leu Ser  Thr Ala Lys Glu Leu  Asn Met Pro 
    1655                 1660                 1665             


Phe Ser  Gly Gly Gln Asp Ser  Phe Ser Lys Phe Thr  Met Glu Met 
    1670                 1675                 1680             


Val Arg  Gln Tyr Met Lys Glu  Glu Glu Met Arg Ala  Ala His Gln 
    1685                 1690                 1695             


Ser Ser  Leu Leu Arg Leu Arg  Glu Lys Ala Leu Lys  Glu Lys Thr 
    1700                 1705                 1710             


Lys Ala  Glu Leu Ala Trp Leu  Glu His Gln Lys Lys  His Leu Arg 
    1715                 1720                 1725             


Asp Lys  Gly Glu Asp Asp Lys  Met Pro Pro Leu Arg  Lys Lys Gln 
    1730                 1735                 1740             


Arg Gly  Leu Leu Leu Arg Leu  Gln Gln Glu Lys Ala  Glu Ile Lys 
    1745                 1750                 1755             


Arg Leu  Gln Glu Ala Asn Lys  Ala Ala Arg Lys Glu  Arg Gln Leu 
    1760                 1765                 1770             


Ile Leu  Lys Gln Gln Glu Glu  Ile Glu Lys Ile Arg  Gln Thr Thr 
    1775                 1780                 1785             


Ile Lys  Leu Gln Glu Lys Leu  Lys Ser Ala Gly Glu  Ser Lys Leu 
    1790                 1795                 1800             


Asp Ser  His Ser Asp Asp Asp  Thr Lys Asp Asn Lys  Ala Thr Ser 
    1805                 1810                 1815             


Pro Gly  Pro Thr Asp Leu Glu  Thr Arg Ser Pro Ser  Pro Ile Ser 
    1820                 1825                 1830             


Ile Ser  Ser Ser Glu Thr Ser  Ser Ile Met Gln Lys  Leu Lys Lys 
    1835                 1840                 1845             


Met Arg  Ser Arg Met Asp Glu  Lys Phe Leu Thr Lys  Arg Glu Gln 
    1850                 1855                 1860             


Lys Leu  Met Gln Arg Arg Gln  His Ala Glu Glu Leu  Leu Glu Trp 
    1865                 1870                 1875             


Lys Arg  Arg Leu Asp Ala Glu  Glu Ala Glu Ile Arg  Gln Met Glu 
    1880                 1885                 1890             


Lys Gln  Ala Leu Ala Ala Trp  Asp Lys Glu Leu Ile  Lys Pro Lys 
    1895                 1900                 1905             


Thr Pro  Lys Lys Glu Leu Glu  Asp Gln Arg Thr Glu  Gln Lys Glu 
    1910                 1915                 1920             


Ile Ala  Ser Glu Glu Glu Ser  Pro Val Pro Leu Tyr  Ser His Leu 
    1925                 1930                 1935             


Asn Ser  Glu Ser Ser Ile Pro  Glu Glu Leu Gly Ser  Pro Ala Val 
    1940                 1945                 1950             


Glu Tyr  Val Pro Ser Glu Ser  Ile Gly Gln Glu Gln  Pro Gly Ser 
    1955                 1960                 1965             


Pro Asp  His Ser Ile Leu Thr  Glu Glu Met Ile Cys  Ser Gln Glu 
    1970                 1975                 1980             


Leu Glu  Ser Ser Thr Ser Pro  Ser Lys His Ser Leu  Pro Lys Ser 
    1985                 1990                 1995             


Cys Thr  Ser Val Ser Lys Gln  Glu Ser Ser Lys Gly  Ser His Arg 
    2000                 2005                 2010             


Thr Gly  Gly Gln Cys His Leu  Pro Ile Lys Ser His  Gln His Cys 
    2015                 2020                 2025             


Tyr Ser  Trp Ser Asp Glu Ser  Leu Ser Met Thr Gln  Ser Glu Thr 
    2030                 2035                 2040             


Thr Ser  Asp Gln Ser Asp Ile  Glu Gly Arg Ile Arg  Ala Leu Lys 
    2045                 2050                 2055             


Asp Glu  Leu Arg Lys Arg Lys  Ser Val Val Asn Gln  Leu Lys Lys 
    2060                 2065                 2070             


Glu Gln  Lys Lys Arg Gln Lys  Glu Arg Leu Lys Ala  Gln Glu Ala 
    2075                 2080                 2085             


Ser Leu  Ile Lys Gln Leu Glu  Ser Tyr Asp Glu Phe  Ile Lys Lys 
    2090                 2095                 2100             


Thr Glu  Ala Glu Leu Ser Gln  Asp Leu Glu Thr Ser  Pro Thr Ala 
    2105                 2110                 2115             


Lys Pro  Gln Ile Lys Thr Leu  Ser Ser Ala Ser Glu  Lys Pro Lys 
    2120                 2125                 2130             


Ile Lys  Pro Leu Thr Pro Leu  His Arg Ser Glu Thr  Ala Lys Asn 
    2135                 2140                 2145             


Trp Lys  Ser Leu Thr Glu Ser  Glu Arg Ser Arg Gly  Ser Leu Glu 
    2150                 2155                 2160             


Ser Ile  Ala Glu His Val Asp  Ala Ser Leu Ser Gly  Ser Glu Arg 
    2165                 2170                 2175             


Ser Val  Ser Glu Arg Ser Leu  Ser Ala Tyr Ala Lys  Arg Val Asn 
    2180                 2185                 2190             


Glu Trp  Asp Ser Arg Thr Glu  Asp Phe Gln Thr Pro  Ser Pro Val 
    2195                 2200                 2205             


Leu Arg  Ser Ser Arg Lys Ile  Arg Glu Glu Ser Gly  Asp Ser Leu 
    2210                 2215                 2220             


Glu Asn  Val Pro Ala Leu His  Leu Leu Lys Glu Leu  Asn Ala Thr 
    2225                 2230                 2235             


Ser Arg  Ile Leu Asp Met Ser  Asp Gly Lys Val Gly  Glu Ser Ser 
    2240                 2245                 2250             


Lys Lys  Ser Glu Ile Lys Glu  Ile Glu Tyr Thr Lys  Leu Lys Lys 
    2255                 2260                 2265             


Ser Lys  Ile Glu Asp Ala Phe  Ser Lys Glu Gly Lys  Ser Asp Val 
    2270                 2275                 2280             


Leu Leu  Lys Leu Val Leu Glu  Gln Gly Asp Ser Ser  Glu Ile Leu 
    2285                 2290                 2295             


Ser Lys  Lys Asp Leu Pro Leu  Asp Ser Glu Asn Val  Gln Lys Asp 
    2300                 2305                 2310             


Leu Val  Gly Leu Ala Ile Glu  Asn Leu His Lys Ser  Glu Glu Met 
    2315                 2320                 2325             


Leu Lys  Glu Arg Gln Ser Asp  Gln Asp Met Asn His  Ser Pro Asn 
    2330                 2335                 2340             


Ile Gln  Ser Gly Lys Asp Ile  His Glu Gln Lys Asn  Thr Lys Glu 
    2345                 2350                 2355             


Lys Asp  Leu Ser Trp Ser Glu  His Leu Phe Ala Pro  Lys Glu Ile 
    2360                 2365                 2370             


Pro Tyr  Ser Glu Asp Phe Glu  Val Ser Ser Phe Lys  Lys Glu Ile 
    2375                 2380                 2385             


Ser Ala  Glu Leu Tyr Lys Asp  Asp Phe Glu Val Ser  Ser Leu Leu 
    2390                 2395                 2400             


Ser Leu  Arg Lys Asp Ser Gln  Ser Cys Arg Asp Lys  Pro Gln Pro 
    2405                 2410                 2415             


Met Arg  Ser Ser Thr Ser Gly  Ala Thr Ser Phe Gly  Ser Asn Glu 
    2420                 2425                 2430             


Glu Ile  Ser Glu Cys Leu Ser  Glu Lys Ser Leu Ser  Ile His Ser 
    2435                 2440                 2445             


Asn Val  His Ser Asp Arg Leu  Leu Glu Leu Lys Ser  Pro Thr Glu 
    2450                 2455                 2460             


Leu Met  Lys Ser Lys Glu Arg  Ser Asp Val Glu His  Glu Gln Gln 
    2465                 2470                 2475             


Val Thr  Glu Ser Pro Ser Leu  Ala Ser Val Pro Thr  Ala Asp Glu 
    2480                 2485                 2490             


Leu Phe  Asp Phe His Ile Gly  Asp Arg Val Leu Ile  Gly Asn Val 
    2495                 2500                 2505             


Gln Pro  Gly Ile Leu Arg Phe  Lys Gly Glu Thr Ser  Phe Ala Lys 
    2510                 2515                 2520             


Gly Phe  Trp Ala Gly Val Glu  Leu Asp Lys Pro Glu  Gly Asn Asn 
    2525                 2530                 2535             


Asn Gly  Thr Tyr Asp Gly Ile  Ala Tyr Phe Glu Cys  Lys Glu Lys 
    2540                 2545                 2550             


His Gly  Ile Phe Ala Pro Pro  Gln Lys Ile Ser His  Ile Pro Glu 
    2555                 2560                 2565             


Asn Phe  Asp Asp Tyr Val Asp  Ile Asn Glu Asp Glu  Asp Cys Tyr 
    2570                 2575                 2580             


Ser Asp  Glu Arg Tyr Gln Cys  Tyr Asn Gln Glu Gln  Asn Asp Thr 
    2585                 2590                 2595             


Glu Gly  Pro Lys Asp Arg Glu  Lys Asp Val Ser Glu  Tyr Phe Tyr 
    2600                 2605                 2610             


Glu Lys  Ser Leu Pro Ser Val  Asn Asp Ile Glu Ala  Ser Val Asn 
    2615                 2620                 2625             


Arg Ser  Arg Ser Leu Lys Ile  Glu Thr Asp Asn Val  Gln Asp Ile 
    2630                 2635                 2640             


Ser Gly  Val Leu Glu Ala His  Val His Gln Gln Ser  Ser Val Asp 
    2645                 2650                 2655             


Ser Gln  Ile Ser Ser Lys Glu  Asn Lys Asp Leu Ile  Ser Asp Ala 
    2660                 2665                 2670             


Thr Glu  Lys Val Ser Ile Ala  Ala Glu Asp Asp Thr  Leu Asp Asn 
    2675                 2680                 2685             


Thr Phe  Ser Glu Glu Leu Glu  Lys Gln Gln Gln Phe  Thr Glu Glu 
    2690                 2695                 2700             


Glu Asp  Asn Leu Tyr Ala Glu  Ala Ser Glu Lys Leu  Cys Thr Pro 
    2705                 2710                 2715             


Leu Leu  Asp Leu Leu Thr Arg  Glu Lys Asn Gln Leu  Glu Ala Gln 
    2720                 2725                 2730             


Leu Lys  Ser Ser Leu Asn Glu  Glu Lys Lys Ser Lys  Gln Gln Leu 
    2735                 2740                 2745             


Glu Lys  Ile Ser Leu Leu Thr  Asp Ser Leu Leu Lys  Val Phe Val 
    2750                 2755                 2760             


Lys Asp  Thr Val Asn Gln Leu  Gln Gln Ile Lys Lys  Thr Arg Asp 
    2765                 2770                 2775             


Glu Lys  Ile Gln Leu Ser Asn  Gln Glu Leu Leu Gly  Asp Asp Gln 
    2780                 2785                 2790             


Lys Lys  Val Thr Pro Gln Asp  Leu Ser Gln Asn Val  Glu Glu Gln 
    2795                 2800                 2805             


Ser Pro  Ser Ile Ser Gly Cys  Phe Leu Ser Ser Glu  Leu Glu Asp 
    2810                 2815                 2820             


Glu Lys  Glu Glu Ile Ser Ser  Pro Asp Met Cys Pro  Arg Pro Glu 
    2825                 2830                 2835             


Ser Pro  Val Phe Gly Ala Ser  Gly Gln Glu Glu Leu  Ala Lys Arg 
    2840                 2845                 2850             


Leu Ala  Glu Leu Glu Leu Ser  Arg Glu Phe Leu Ser  Ala Leu Gly 
    2855                 2860                 2865             


Asp Asp  Gln Asp Trp Phe Asp  Glu Asp Phe Gly Leu  Ser Ser Ser 
    2870                 2875                 2880             


His Lys  Ile Gln Lys Asn Lys  Ala Glu Glu Thr Ile  Val Pro Leu 
    2885                 2890                 2895             


Met Ala  Glu Pro Lys Arg Val  Thr Gln Gln Pro Cys  Glu Thr Leu 
    2900                 2905                 2910             


Leu Ala  Val Pro His Thr Ala  Glu Glu Val Glu Ile  Leu Val His 
    2915                 2920                 2925             


Asn Ala  Ala Glu Glu Leu Trp  Lys Trp Lys Glu Leu  Gly His Asp 
    2930                 2935                 2940             


Leu His  Ser Ile Ser Ile Pro  Thr Lys Leu Leu Gly  Cys Ala Ser 
    2945                 2950                 2955             


Lys Gly  Leu Asp Ile Glu Ser  Thr Ser Lys Arg Val  Tyr Lys Gln 
    2960                 2965                 2970             


Ala Val  Phe Asp Leu Thr Lys  Glu Ile Phe Glu Glu  Ile Phe Ala 
    2975                 2980                 2985             


Glu Asp  Pro Asn Leu Asn Gln  Pro Val Trp Met Lys  Pro Cys Arg 
    2990                 2995                 3000             


Ile Asn  Ser Ser Tyr Phe Arg  Arg Val Lys Asn Pro  Asn Asn Leu 
    3005                 3010                 3015             


Asp Glu  Ile Lys Ser Phe Ile  Ala Ser Glu Val Leu  Lys Leu Phe 
    3020                 3025                 3030             


Ser Leu  Lys Lys Glu Pro Asn  His Lys Thr Asp Trp  Gln Lys Met 
    3035                 3040                 3045             


Met Lys  Phe Gly Arg Lys Lys  Arg Asp Arg Val Asp  His Ile Leu 
    3050                 3055                 3060             


Val Gln  Glu Leu His Glu Glu  Glu Ala Gln Trp Val  Asn Tyr Asp 
    3065                 3070                 3075             


Glu Asp  Glu Leu Cys Val Lys  Met Gln Leu Ala Asp  Gly Ile Phe 
    3080                 3085                 3090             


Glu Thr  Leu Ile Lys Asp Thr  Ile Asp Val Leu Asn  Gln Ile Ser 
    3095                 3100                 3105             


Glu Lys  Gln Gly Arg Met Leu  Leu Val 
    3110                 3115         


<210> 6116
<211> 981
<212> PRT
<213> Homo sapiens

<400> 6116
Met Ser Glu Gln Glu Arg Ile Gln Glu Cys Leu Arg Lys Glu Ile Arg 
1               5                   10                  15      


Ser Leu Leu Ile Ser Thr Lys Asp Gly Leu Ser Pro Gln Glu Leu Glu 
            20                  25                  30          


Lys Glu Tyr Leu Leu Met Val Gly Asn His Leu Pro Leu Arg Ile Leu 
        35                  40                  45              


Gly Tyr Arg Ser Thr Met Glu Leu Val Leu Asp Met Pro Asp Val Val 
    50                  55                  60                  


Arg Val Cys Pro Gly Ala Gly Gly Thr Val Ile Leu Lys Ala Ile Pro 
65                  70                  75                  80  


Asp Glu Ser Thr Lys Gly Ile Ala Ser Leu Val Ala Lys Gln Arg Ser 
                85                  90                  95      


Ser His Lys Leu Arg Asn Ser Met His Lys Gly Arg Pro Ser Ile Tyr 
            100                 105                 110         


Ser Gly Pro Arg Ser His Arg Arg Val Pro Tyr Arg Gly Arg Val Ala 
        115                 120                 125             


Pro Ile Leu Pro Ala Val Val Lys Ser Glu Leu Lys Asp Leu Leu Ala 
    130                 135                 140                 


Leu Ser Pro Val Leu Leu Ser Asp Phe Glu Lys Ala Phe Ala Lys Arg 
145                 150                 155                 160 


Phe Gly Arg Ser Phe Gln Tyr Met Gln Tyr Gly Phe Leu Ser Met Phe 
                165                 170                 175     


Glu Val Leu Asn Ala Ala Ser Asp Val Ile Ser Val Glu Gln Thr Arg 
            180                 185                 190         


Ala Gly Ser Leu Leu Met Leu Lys Lys Ser Val Thr Glu Glu Lys Pro 
        195                 200                 205             


Arg Gly Cys Pro Ala Gly Lys Ile Phe Thr Gln Pro Phe Arg Met Lys 
    210                 215                 220                 


Gln Gly Ser Tyr Ser Thr Gly Phe Pro Val Ala Lys Pro Cys Phe Ser 
225                 230                 235                 240 


Gln Pro Thr Ser Asn Met Glu Pro Pro Lys Gln Ile Met Ser Met Glu 
                245                 250                 255     


Lys Thr Ser Lys Leu Asn Val Val Glu Thr Ser Arg Leu Asn His Thr 
            260                 265                 270         


Glu Lys Leu Asn Gln Leu Glu Asn Thr Phe Lys Ser Val Ile Ala Gln 
        275                 280                 285             


Ile Gly Pro Gly Gly Thr Ile Ser Ser Glu Leu Lys His Lys Ile Lys 
    290                 295                 300                 


Phe Val Val Ser Lys Phe Pro Glu Gly Leu Phe Ile Ser Lys Leu Leu 
305                 310                 315                 320 


Gly Glu Tyr Glu Val Ile Phe Lys Glu Gln Leu Ser Pro Lys Lys Leu 
                325                 330                 335     


Gly Phe Leu Asn Val Thr Glu Leu Val Gly Ala Leu Ser Asp Ile Leu 
            340                 345                 350         


His Val Glu Phe Arg Lys Gly His Gln Asp Leu Leu Val Phe Asp Ala 
        355                 360                 365             


Asp Lys Lys Pro Leu Pro Pro Val Gln Ser Asp Lys Lys Ile Glu Ala 
    370                 375                 380                 


Lys Ala Cys Val Ser Ser Pro Pro Arg Asn Ser Leu Ser Thr Ala Ala 
385                 390                 395                 400 


Val Lys Glu Thr Val Trp Asn Cys Pro Ser Lys Lys Gln Lys Glu Pro 
                405                 410                 415     


Gln Gln Lys Ile Cys Lys Lys Pro Asn Leu Val Val Lys Pro Leu Gln 
            420                 425                 430         


Leu Gln Val Glu Thr Asn Lys Ser Glu Leu Asn Leu Ala Met Ala Asn 
        435                 440                 445             


His Asp Ile Pro Pro Asp Ala Val Pro Asn Lys Lys Leu Cys Arg Leu 
    450                 455                 460                 


Pro Pro Leu Asp Thr Ser Ser Leu Ile Gly Val Phe Val Glu Tyr Ile 
465                 470                 475                 480 


Ile Ser Pro Ser Gln Phe Tyr Ile Arg Ile Tyr Ser Arg Asp Ser Ser 
                485                 490                 495     


Glu Leu Leu Glu Asp Met Met Ile Glu Met Arg Arg Cys Tyr Ser Asn 
            500                 505                 510         


Gln Leu Val Ser Asp Arg Tyr Val Met Pro Glu Cys Phe Ile Gln Pro 
        515                 520                 525             


Gly His Leu Cys Cys Val Arg Ile Ser Glu Asp Lys Trp Trp Tyr Arg 
    530                 535                 540                 


Val Ile Ile His Arg Val Leu Glu Lys Gln Glu Val Glu Val Phe Tyr 
545                 550                 555                 560 


Pro Asp Phe Gly Asn Ile Gly Ile Val Gln Lys Ser Ser Leu Arg Phe 
                565                 570                 575     


Leu Lys Cys Cys Tyr Thr Lys Leu Pro Ala Gln Ala Ile Pro Cys Ser 
            580                 585                 590         


Leu Ala Trp Val Arg Pro Val Glu Glu His Trp Thr Ser Lys Ala Ile 
        595                 600                 605             


Leu Gln Phe Gln Lys Leu Cys Gly Leu Lys Pro Leu Val Gly Val Val 
    610                 615                 620                 


Asp Glu Tyr Val Asp Gly Ile Leu Asn Ile Phe Leu Cys Asp Thr Ser 
625                 630                 635                 640 


Ser Asn Glu Asp Val Tyr Phe His His Val Leu Arg Thr Glu Gly His 
                645                 650                 655     


Ala Ile Val Cys Arg Glu Asn Ile Ser Ser Lys Gly Phe Ser Glu Leu 
            660                 665                 670         


Asn Pro Leu Ala Leu Tyr Thr Thr Ser Ser Gly Gly Pro Glu Asp Ile 
        675                 680                 685             


Val Leu Thr Glu Leu Gly Tyr Pro Ser Gln Gln His Tyr Phe Asn Glu 
    690                 695                 700                 


Asp Arg Lys Ile Ser Pro Gln Ser Lys Glu Ser Glu Leu Arg Ile Leu 
705                 710                 715                 720 


Asp Glu Ile Pro Thr Gly Met Pro Cys Leu Glu Ser Val Thr Ile Gly 
                725                 730                 735     


Asp Asp Ile Trp Asp Glu Asn Trp Leu Pro Leu Gln Ala Lys Met Gly 
            740                 745                 750         


Lys Gly Gly Asp Ala Ala Ser His Leu Phe Thr Ala Ser Leu Gly Gly 
        755                 760                 765             


Lys Asn Gln Tyr Ser Ser Cys Lys Glu Met Pro Gln Lys Asp Trp Cys 
    770                 775                 780                 


Phe Ser Thr Pro Lys Asp Thr Trp Asp Asp Ser Trp Gln Pro Ser Gly 
785                 790                 795                 800 


Leu Val Asn Gly Thr Lys Val Glu Val His Lys Pro Glu Val Leu Gly 
                805                 810                 815     


Ala Gln Glu Lys Asn Thr Gly Thr Asn Arg Thr Gln Lys Gln Leu Asp 
            820                 825                 830         


Ile Asn Gly Ser Ser Asp Ser Ser Thr Leu Pro Lys Leu Glu Glu Phe 
        835                 840                 845             


Cys Thr Ser Leu Thr Gln Ser Glu Gln Ser Ala Asp Gly Ser Gln Ser 
    850                 855                 860                 


Glu Pro Asn Asn Ser Gln Thr Gln Pro Lys Gln Ile Gln Leu Ser Thr 
865                 870                 875                 880 


Ala Ala Pro Cys Ser Thr Thr Ala Val Asp Asp Ser Ala Glu Lys Pro 
                885                 890                 895     


Ser Gly Ser Val Glu Ser Ser Pro Glu Ile Leu Lys Asn Glu Asp Phe 
            900                 905                 910         


Ser Ser Ser Arg Ala Ile Thr Leu Tyr Lys Asp Lys Arg Gln Glu Ser 
        915                 920                 925             


Val Asp Gln Leu Ser Leu Ile Leu Ser Tyr Glu Cys Gln Ile Ser Gln 
    930                 935                 940                 


Lys Leu Tyr Ile Pro Arg Ser Thr Ala Thr Ala Ala Leu Gly Ala Ala 
945                 950                 955                 960 


Ala Arg Leu Ala Thr Ser Arg Ser Leu Leu His Trp Tyr Pro Ser Val 
                965                 970                 975     


Lys Arg Met Glu Ala 
            980     


<210> 6117
<211> 215
<212> PRT
<213> Homo sapiens

<400> 6117
Met Ser Ala Lys Arg Ala Glu Leu Lys Lys Thr His Leu Val Lys Glu 
1               5                   10                  15      


Arg His Cys Trp Thr Ser Lys Asn Tyr Lys Ala Val Cys Leu Glu Leu 
            20                  25                  30          


Lys Pro Glu Pro Thr Lys Thr Phe Asp Tyr Lys Ala Val Lys Gln Glu 
        35                  40                  45              


Gly Arg Phe Thr Lys Ala Gly Val Thr Gln Asp Leu Lys Asn Glu Leu 
    50                  55                  60                  


Arg Glu Val Arg Glu Glu Leu Lys Glu Lys Met Glu Glu Ile Lys Gln 
65                  70                  75                  80  


Ile Lys Asp Leu Met Asp Lys Asp Phe Asp Lys Leu His Glu Phe Val 
                85                  90                  95      


Glu Ile Met Lys Glu Met Gln Lys Asp Met Asp Glu Lys Met Asp Ile 
            100                 105                 110         


Leu Ile Asn Thr Gln Lys Asn Tyr Lys Leu Pro Leu Arg Arg Ala Pro 
        115                 120                 125             


Lys Glu Gln Gln Glu Leu Arg Leu Met Gly Lys Thr His Arg Glu Pro 
    130                 135                 140                 


Gln Leu Arg Pro Lys Lys Met Asp Gly Ala Ser Gly Val Asn Gly Ala 
145                 150                 155                 160 


Pro Cys Ala Leu His Lys Lys Thr Met Ala Pro Gln Lys Thr Lys Gln 
                165                 170                 175     


Gly Ser Leu Asp Pro Leu His His Cys Gly Thr Cys Cys Glu Lys Cys 
            180                 185                 190         


Leu Leu Cys Ala Leu Lys Asn Asn Tyr Asn Arg Gly Ile Tyr Ala Ala 
        195                 200                 205             


Val Gly Leu Leu Asp Leu Trp 
    210                 215 


<210> 6118
<211> 201
<212> PRT
<213> Homo sapiens

<400> 6118
Met Ser Ala Lys Arg Ala Glu Leu Lys Lys Thr His Leu Ser Lys Asn 
1               5                   10                  15      


Tyr Lys Ala Val Cys Leu Glu Leu Lys Pro Glu Pro Thr Lys Thr Phe 
            20                  25                  30          


Asp Tyr Lys Ala Val Lys Gln Glu Gly Arg Phe Thr Lys Ala Gly Val 
        35                  40                  45              


Thr Gln Asp Leu Lys Asn Glu Leu Arg Glu Val Arg Glu Glu Leu Lys 
    50                  55                  60                  


Glu Lys Met Glu Glu Ile Lys Gln Ile Lys Asp Leu Met Asp Lys Asp 
65                  70                  75                  80  


Phe Asp Lys Leu His Glu Phe Val Glu Ile Met Lys Glu Met Gln Lys 
                85                  90                  95      


Asp Met Asp Glu Lys Met Asp Ile Leu Ile Asn Thr Gln Lys Asn Tyr 
            100                 105                 110         


Lys Leu Pro Leu Arg Arg Ala Pro Lys Glu Gln Gln Glu Leu Arg Leu 
        115                 120                 125             


Met Gly Lys Thr His Arg Glu Pro Gln Leu Arg Pro Lys Lys Met Asp 
    130                 135                 140                 


Gly Ala Ser Gly Val Asn Gly Ala Pro Cys Ala Leu His Lys Lys Thr 
145                 150                 155                 160 


Met Ala Pro Gln Lys Thr Lys Gln Gly Ser Leu Asp Pro Leu His His 
                165                 170                 175     


Cys Gly Thr Cys Cys Val Ser Glu Thr Leu Pro Glu Pro Ser Thr Gly 
            180                 185                 190         


Ala Arg Pro Leu Ala Pro Ala Pro Trp 
        195                 200     


<210> 6119
<211> 99
<212> PRT
<213> Homo sapiens

<400> 6119
Met Ser Ala Lys Arg Ala Glu Leu Lys Lys Thr His Leu Ser Lys Asn 
1               5                   10                  15      


Tyr Lys Ala Val Cys Leu Glu Leu Lys Pro Glu Pro Thr Lys Val Arg 
            20                  25                  30          


Ser Pro Phe Glu Ala Met Gln Ala Ala Arg Pro Glu Ile His Gly Glu 
        35                  40                  45              


Val Thr Arg Ser Gln Gly Ser Phe Ala Asp Pro Ser Gly Gln Asp Leu 
    50                  55                  60                  


Ser Gln Thr Phe Asp Tyr Lys Ala Val Lys Gln Glu Gly Arg Phe Thr 
65                  70                  75                  80  


Lys Ala Gly Arg Thr Pro Arg Leu Leu Glu Glu Leu Ser Leu Leu Leu 
                85                  90                  95      


Leu Pro Leu 
            


<210> 6120
<211> 212
<212> PRT
<213> Homo sapiens

<400> 6120
Met Ser Ala Lys Arg Ala Glu Leu Lys Lys Thr His Leu Ser Lys Asn 
1               5                   10                  15      


Tyr Lys Ala Val Cys Leu Glu Leu Lys Pro Glu Pro Thr Lys Thr Phe 
            20                  25                  30          


Asp Tyr Lys Ala Val Lys Gln Glu Gly Arg Phe Thr Lys Ala Gly Val 
        35                  40                  45              


Thr Gln Asp Leu Lys Asn Glu Leu Arg Glu Val Arg Glu Glu Leu Lys 
    50                  55                  60                  


Glu Lys Met Glu Glu Ile Lys Gln Ile Lys Asp Leu Met Asp Lys Asp 
65                  70                  75                  80  


Phe Asp Lys Leu His Glu Phe Val Glu Ile Met Lys Glu Met Gln Lys 
                85                  90                  95      


Asp Met Asp Glu Lys Met Asp Ile Leu Ile Asn Thr Gln Lys Asn Tyr 
            100                 105                 110         


Lys Leu Pro Leu Arg Arg Ala Pro Lys Glu Gln Gln Glu Leu Arg Leu 
        115                 120                 125             


Met Gly Lys Thr His Arg Glu Pro Gln Leu Arg Pro Lys Lys Met Asp 
    130                 135                 140                 


Gly Ala Ser Gly Val Asn Gly Ala Pro Cys Ala Leu His Lys Lys Thr 
145                 150                 155                 160 


Met Ala Pro Gln Lys Thr Lys Gln Gly Ser Leu Asp Pro Leu His His 
                165                 170                 175     


Cys Gly Thr Cys Cys Glu Lys Cys Leu Leu Cys Ala Leu Lys Asn Asn 
            180                 185                 190         


Tyr Asn Arg Ala Gln Leu Gln Asn Leu Pro Ala Val Pro Ile His His 
        195                 200                 205             


Leu Gln Ala Pro 
    210         


<210> 6121
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6121
Xaa Tyr Glu Leu Arg Glu Glu His Leu Asp Lys Ile Phe Lys His Arg 
1               5                   10                  15      


Glu Leu Gln Gln Lys Leu Val Asp Ala Lys Leu Glu Gln Ala Gln Glu 
            20                  25                  30          


Met Met Lys Glu Ala Glu Glu Arg His Lys Arg Glu Lys Glu Tyr Leu 
        35                  40                  45              


Leu Asn Gln Ala Ala Glu Trp Lys Leu Gln Ala Lys Val Leu Lys Glu 
    50                  55                  60                  


Gln Glu Thr Val Leu Gln Ala Gln Val Arg Pro Gly Gly Arg Gly Met 
65                  70                  75                  80  


Gly Val Leu Ser Ser Leu Ser Pro Asp Lys Lys Ala Gly Ala Lys Gly 
                85                  90                  95      


Gly Gln Gln Lys Ser Ser Tyr Val Ala Gly Asp Gly Gly Met Gly Ile 
            100                 105                 110         


Gly Asn Glu Glu Gln Leu His Ile Tyr Ser Tyr Phe Gln Val Lys Ile 
        115                 120                 125             


Lys Ala Gln Tyr Tyr 
    130             


<210> 6122
<211> 228
<212> PRT
<213> Homo sapiens

<400> 6122
Met Ala Ser Glu Glu Leu Gln Lys Asp Leu Glu Glu Val Lys Val Leu 
1               5                   10                  15      


Leu Glu Lys Ala Thr Arg Lys Arg Val Arg Asp Ala Leu Thr Ala Glu 
            20                  25                  30          


Lys Ser Lys Ile Glu Thr Glu Ile Lys Asn Lys Met Gln Gln Lys Ser 
        35                  40                  45              


Gln Lys Lys Ala Glu Leu Leu Asp Asn Glu Lys Pro Ala Ala Val Val 
    50                  55                  60                  


Ala Pro Ile Thr Thr Gly Tyr Thr Val Lys Ile Ser Asn Tyr Gly Trp 
65                  70                  75                  80  


Asp Gln Ser Asp Lys Phe Val Lys Ile Tyr Ile Thr Leu Thr Gly Val 
                85                  90                  95      


His Gln Val Pro Thr Glu Asn Val Gln Val His Phe Thr Glu Arg Ser 
            100                 105                 110         


Phe Asp Leu Leu Val Lys Asn Leu Asn Gly Lys Ser Tyr Ser Met Ile 
        115                 120                 125             


Val Asn Asn Leu Leu Lys Pro Ile Ser Val Glu Gly Ser Ser Lys Lys 
    130                 135                 140                 


Val Lys Thr Asp Thr Val Leu Ile Leu Cys Arg Lys Lys Val Glu Asn 
145                 150                 155                 160 


Thr Arg Trp Asp Tyr Leu Thr Gln Val Glu Lys Glu Cys Lys Glu Lys 
                165                 170                 175     


Glu Lys Pro Ser Tyr Asp Thr Glu Thr Asp Pro Ser Glu Gly Leu Met 
            180                 185                 190         


Asn Val Leu Lys Lys Ile Tyr Glu Asp Gly Asp Asp Asp Met Lys Arg 
        195                 200                 205             


Thr Ile Asn Lys Ala Trp Val Glu Ser Arg Glu Lys Gln Ala Lys Gly 
    210                 215                 220                 


Asp Thr Glu Phe 
225             


<210> 6123
<211> 185
<212> PRT
<213> Homo sapiens

<400> 6123
Met Gln Gln Lys Ser Gln Lys Lys Ala Glu Leu Leu Asp Asn Glu Lys 
1               5                   10                  15      


Pro Ala Ala Val Val Ala Pro Ile Thr Thr Gly Tyr Thr Val Lys Ile 
            20                  25                  30          


Ser Asn Tyr Gly Trp Asp Gln Ser Asp Lys Phe Val Lys Ile Tyr Ile 
        35                  40                  45              


Thr Leu Thr Gly Val His Gln Val Pro Thr Glu Asn Val Gln Val His 
    50                  55                  60                  


Phe Thr Glu Arg Ser Phe Asp Leu Leu Val Lys Asn Leu Asn Gly Lys 
65                  70                  75                  80  


Ser Tyr Ser Met Ile Val Asn Asn Leu Leu Lys Pro Ile Ser Val Glu 
                85                  90                  95      


Gly Ser Ser Lys Lys Val Lys Thr Asp Thr Val Leu Ile Leu Cys Arg 
            100                 105                 110         


Lys Lys Val Glu Asn Thr Arg Trp Asp Tyr Leu Thr Gln Val Glu Lys 
        115                 120                 125             


Glu Cys Lys Glu Lys Glu Lys Pro Ser Tyr Asp Thr Glu Thr Asp Pro 
    130                 135                 140                 


Ser Glu Gly Leu Met Asn Val Leu Lys Lys Ile Tyr Glu Asp Gly Asp 
145                 150                 155                 160 


Asp Asp Met Lys Arg Thr Ile Asn Lys Ala Trp Val Glu Ser Arg Glu 
                165                 170                 175     


Lys Gln Ala Lys Gly Asp Thr Glu Phe 
            180                 185 


<210> 6124
<211> 377
<212> PRT
<213> Homo sapiens

<400> 6124
Met Glu Gln Leu Pro Asp Leu His Ser His Phe Ser Asp Leu Asn Leu 
1               5                   10                  15      


Glu Ala His Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe Thr Ala 
            20                  25                  30          


Lys Phe Pro Leu Cys Met Val Phe His Ile Ile Asp Leu Leu Leu Cys 
        35                  40                  45              


Glu Gly Leu Asn Ile Ile Phe His Val Ala Leu Ala Leu Leu Lys Thr 
    50                  55                  60                  


Ser Lys Glu Asp Leu Leu Gln Ala Asp Phe Glu Gly Ala Leu Lys Phe 
65                  70                  75                  80  


Phe Arg Val Gln Leu Pro Lys Arg Tyr Arg Ala Glu Glu Asn Ala Arg 
                85                  90                  95      


Arg Leu Met Glu Gln Ala Cys Asn Ile Lys Val Pro Thr Lys Lys Leu 
            100                 105                 110         


Lys Lys Tyr Glu Lys Glu Tyr Gln Thr Met Arg Glu Ser Gln Leu Gln 
        115                 120                 125             


Gln Glu Asp Pro Met Asp Arg Tyr Lys Arg Glu Asn Arg Arg Leu Gln 
    130                 135                 140                 


Glu Ala Ser Met Arg Leu Glu Gln Glu Asn Asp Asp Leu Ala His Glu 
145                 150                 155                 160 


Leu Val Thr Ser Lys Ile Ala Leu Arg Asn Asp Leu Asp Gln Ala Glu 
                165                 170                 175     


Asp Lys Ala Asp Val Leu Asn Lys Glu Leu Leu Leu Thr Lys Gln Arg 
            180                 185                 190         


Leu Val Glu Thr Glu Glu Glu Lys Arg Lys Gln Glu Glu Glu Thr Ala 
        195                 200                 205             


Gln Leu Lys Glu Val Phe Arg Lys Gln Leu Glu Lys Ala Glu Tyr Glu 
    210                 215                 220                 


Ile Lys Lys Thr Thr Ala Ile Ile Ala Glu Tyr Lys Gln Ile Cys Ser 
225                 230                 235                 240 


Gln Leu Ser Thr Arg Leu Glu Lys Gln Gln Ala Ala Ser Lys Glu Glu 
                245                 250                 255     


Leu Glu Val Val Lys Gly Lys Met Met Ala Cys Lys His Cys Ser Asp 
            260                 265                 270         


Ile Phe Ser Lys Glu Gly Ala Leu Lys Leu Ala Ala Thr Gly Arg Glu 
        275                 280                 285             


Asp Gln Gly Ile Glu Thr Asp Asp Glu Lys Asp Ser Leu Lys Lys Gln 
    290                 295                 300                 


Leu Arg Glu Met Glu Leu Glu Leu Ala Gln Thr Lys Leu Gln Leu Val 
305                 310                 315                 320 


Glu Ala Lys Cys Lys Ile Gln Glu Leu Glu His Gln Arg Gly Ala Leu 
                325                 330                 335     


Met Asn Glu Ile Gln Ala Ala Lys Asn Ser Trp Phe Ser Lys Thr Leu 
            340                 345                 350         


Asn Ser Ile Lys Thr Ala Thr Gly Thr Gln Pro Leu Gln Pro Ala Pro 
        355                 360                 365             


Val Thr Gln Pro Pro Lys Glu Ser Thr 
    370                 375         


<210> 6125
<211> 253
<212> PRT
<213> Homo sapiens

<400> 6125
Met Ile Glu Asn Ser Ser Trp Ser Met Thr Phe Glu Glu Arg Glu Asn 
1               5                   10                  15      


Arg Arg Leu Gln Glu Ala Ser Met Arg Leu Glu Gln Glu Asn Asp Asp 
            20                  25                  30          


Leu Ala His Glu Leu Val Thr Ser Lys Ile Ala Leu Arg Asn Asp Leu 
        35                  40                  45              


Asp Gln Ala Glu Asp Lys Ala Asp Val Leu Asn Lys Glu Leu Leu Leu 
    50                  55                  60                  


Thr Lys Gln Arg Leu Val Glu Thr Glu Glu Glu Lys Arg Lys Gln Glu 
65                  70                  75                  80  


Glu Glu Thr Ala Gln Leu Lys Glu Val Phe Arg Lys Gln Leu Glu Lys 
                85                  90                  95      


Ala Glu Tyr Glu Ile Lys Lys Thr Thr Ala Ile Ile Ala Glu Tyr Lys 
            100                 105                 110         


Gln Ile Cys Ser Gln Leu Ser Thr Arg Leu Glu Lys Gln Gln Ala Ala 
        115                 120                 125             


Ser Lys Glu Glu Leu Glu Val Val Lys Gly Lys Met Met Ala Cys Lys 
    130                 135                 140                 


His Cys Ser Asp Ile Phe Ser Lys Glu Gly Ala Leu Lys Leu Ala Ala 
145                 150                 155                 160 


Thr Gly Arg Glu Asp Gln Gly Ile Glu Thr Asp Asp Glu Lys Asp Ser 
                165                 170                 175     


Leu Lys Lys Gln Leu Arg Glu Met Glu Leu Glu Leu Ala Gln Thr Lys 
            180                 185                 190         


Leu Gln Leu Val Glu Ala Lys Cys Lys Ile Gln Glu Leu Glu His Gln 
        195                 200                 205             


Arg Gly Ala Leu Met Asn Glu Ile Gln Ala Ala Lys Asn Ser Trp Phe 
    210                 215                 220                 


Ser Lys Thr Leu Asn Ser Ile Lys Thr Ala Thr Gly Thr Gln Pro Leu 
225                 230                 235                 240 


Gln Pro Ala Pro Val Thr Gln Pro Pro Lys Glu Ser Thr 
                245                 250             


<210> 6126
<211> 252
<212> PRT
<213> Homo sapiens

<400> 6126
Met Gly Lys Ser Tyr Asp Gly Arg Ala Tyr Val Ile Thr Gly Met Trp 
1               5                   10                  15      


Asn Pro Asn Ala Pro Val Phe Leu Ala Leu Asn Glu Glu Thr Pro Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Met Thr Val Ala Val Asp Met Val Val Thr Glu 
        35                  40                  45              


Val Val Glu Pro Val Arg Phe Leu Leu Glu Thr Val Val Arg Val Tyr 
    50                  55                  60                  


Pro Ala Asn Glu Arg Phe Trp Tyr Phe Ser Arg Lys Thr Phe Thr Glu 
65                  70                  75                  80  


Thr Phe Phe Met Arg Leu Lys Gln Ser Glu Gly Lys Gly His Thr Asn 
                85                  90                  95      


Ala Gly Asp Ala Ile Tyr Glu Val Val Ser Leu Gln Arg Glu Ser Asp 
            100                 105                 110         


Lys Glu Glu Pro Val Thr Pro Thr Ser Gly Gly Gly Pro Met Ser Pro 
        115                 120                 125             


Gln Asp Asp Glu Ala Glu Glu Glu Ser Asp Asn Glu Leu Ser Ser Gly 
    130                 135                 140                 


Thr Gly Asp Val Ser Lys Asp Cys Pro Glu Lys Ile Leu Tyr Ser Trp 
145                 150                 155                 160 


Gly Glu Leu Leu Gly Lys Trp His Ser Asn Leu Gly Ala Arg Pro Lys 
                165                 170                 175     


Gly Leu Ser Thr Leu Val Lys Ser Gly Val Pro Glu Ala Leu Arg Ala 
            180                 185                 190         


Glu Val Trp Gln Leu Leu Ala Gly Cys His Asp Asn Gln Ala Met Leu 
        195                 200                 205             


Asp Arg Tyr Arg Ile Leu Ile Thr Lys Val Cys Trp Ser Leu Leu Glu 
    210                 215                 220                 


Val His Ser Arg Pro Cys Leu Pro Gly Tyr His Gln Trp Lys Leu Gln 
225                 230                 235                 240 


Asn Ser Lys Tyr Cys Arg Met Ala Asn Val Ala Ala 
                245                 250         


<210> 6127
<211> 827
<212> PRT
<213> Homo sapiens

<400> 6127
Met Glu Val Arg Ala Ser Leu Gln Lys Val Ser Gly Ser Ser Asp Ser 
1               5                   10                  15      


Val Ala Thr Met Asn Ser Glu Glu Phe Val Leu Val Pro Gln Tyr Ala 
            20                  25                  30          


Asp Asp Asn Ser Thr Lys His Glu Glu Lys Pro Gln Leu Lys Ile Val 
        35                  40                  45              


Ser Asn Gly Asp Glu Gln Leu Glu Lys Ala Met Glu Glu Ile Leu Arg 
    50                  55                  60                  


Asp Ser Glu Lys Arg Pro Ser Ser Leu Leu Val Asp Cys Gln Ser Ser 
65                  70                  75                  80  


Ser Glu Ile Ser Asp His Ser Phe Gly Asp Ile Pro Ala Ser Gln Thr 
                85                  90                  95      


Asn Lys Pro Ser Leu Gln Leu Ile Leu Asp Pro Ser Asn Thr Glu Ile 
            100                 105                 110         


Ser Thr Pro Arg Pro Ser Ser Pro Gly Gly Leu Pro Glu Glu Asp Ser 
        115                 120                 125             


Val Leu Phe Asn Lys Leu Thr Tyr Leu Gly Cys Met Lys Val Ser Ser 
    130                 135                 140                 


Pro Arg Asn Glu Val Glu Ala Leu Arg Ala Met Ala Thr Met Lys Ser 
145                 150                 155                 160 


Ser Ser Gln Tyr Pro Phe Pro Val Thr Leu Tyr Val Pro Asn Val Pro 
                165                 170                 175     


Glu Gly Ser Val Arg Ile Ile Asp Gln Ser Ser Asn Val Glu Ile Ala 
            180                 185                 190         


Ser Phe Pro Ile Tyr Lys Val Leu Phe Cys Ala Arg Gly His Asp Gly 
        195                 200                 205             


Thr Thr Glu Ser Asn Cys Phe Ala Phe Thr Glu Ser Ser His Gly Ser 
    210                 215                 220                 


Glu Glu Phe Gln Ile His Val Phe Ser Cys Glu Ile Lys Glu Ala Val 
225                 230                 235                 240 


Ser Arg Ile Leu Tyr Ser Phe Cys Thr Ala Phe Lys Arg Ser Ser Arg 
                245                 250                 255     


Gln Val Ser Asp Val Lys Asp Ser Val Ile Pro Thr Pro Asp Ser Asp 
            260                 265                 270         


Val Phe Thr Phe Ser Val Ser Leu Glu Val Lys Glu Asp Asp Gly Lys 
        275                 280                 285             


Gly Asn Phe Arg Leu Leu Val Ile Pro Ile Pro Phe Glu Tyr Phe Ser 
    290                 295                 300                 


Pro Val Pro Lys Asp Arg Asp Lys Phe Tyr Phe Lys Leu Lys Gln Gly 
305                 310                 315                 320 


Ile Glu Lys Lys Val Val Ile Thr Val Gln Gln Leu Ser Asn Lys Glu 
                325                 330                 335     


Leu Ala Ile Glu Arg Cys Phe Gly Met Leu Leu Ser Pro Gly Arg Asn 
            340                 345                 350         


Val Lys Asn Ser Asp Met His Leu Leu Asp Met Glu Ser Met Gly Lys 
        355                 360                 365             


Ser Tyr Asp Gly Arg Ala Tyr Val Ile Thr Gly Met Trp Asn Pro Asn 
    370                 375                 380                 


Ala Pro Val Phe Leu Ala Leu Asn Glu Glu Thr Pro Lys Asp Lys Gln 
385                 390                 395                 400 


Val Tyr Met Thr Val Ala Val Asp Met Val Val Thr Glu Val Val Glu 
                405                 410                 415     


Pro Val Arg Phe Leu Leu Glu Thr Val Val Arg Val Tyr Pro Ala Asn 
            420                 425                 430         


Glu Arg Phe Trp Tyr Phe Ser Arg Lys Thr Phe Thr Glu Thr Phe Phe 
        435                 440                 445             


Met Arg Leu Lys Gln Ser Glu Gly Lys Gly His Thr Asn Ala Gly Asp 
    450                 455                 460                 


Ala Ile Tyr Glu Val Val Ser Leu Gln Arg Glu Ser Asp Lys Glu Glu 
465                 470                 475                 480 


Pro Val Thr Pro Thr Ser Gly Gly Gly Pro Met Ser Pro Gln Asp Asp 
                485                 490                 495     


Glu Ala Glu Glu Glu Ser Asp Asn Glu Leu Ser Ser Gly Thr Gly Asp 
            500                 505                 510         


Val Ser Lys Asp Cys Pro Glu Lys Ile Leu Tyr Ser Trp Gly Glu Leu 
        515                 520                 525             


Leu Gly Lys Trp His Ser Asn Leu Gly Ala Arg Pro Lys Gly Leu Ser 
    530                 535                 540                 


Thr Leu Val Lys Ser Gly Val Pro Glu Ala Leu Arg Ala Glu Val Trp 
545                 550                 555                 560 


Gln Leu Leu Ala Gly Cys His Asp Asn Gln Ala Met Leu Asp Arg Tyr 
                565                 570                 575     


Arg Ile Leu Ile Thr Lys Asp Ser Ala Gln Glu Ser Val Ile Thr Arg 
            580                 585                 590         


Asp Ile His Arg Thr Phe Pro Ala His Asp Tyr Phe Lys Asp Thr Gly 
        595                 600                 605             


Gly Asp Gly Gln Glu Ser Leu Tyr Lys Ile Cys Lys Ala Tyr Ser Val 
    610                 615                 620                 


Tyr Asp Glu Asp Ile Gly Tyr Cys Gln Gly Gln Ser Phe Leu Ala Ala 
625                 630                 635                 640 


Val Leu Leu Leu His Met Pro Glu Glu Gln Ala Phe Cys Val Leu Val 
                645                 650                 655     


Lys Ile Met Tyr Asp Tyr Gly Leu Arg Asp Leu Tyr Arg Asn Asn Phe 
            660                 665                 670         


Glu Asp Leu His Cys Lys Phe Tyr Gln Leu Glu Arg Leu Met Gln Glu 
        675                 680                 685             


Gln Leu Pro Asp Leu His Ser His Phe Ser Asp Leu Asn Leu Glu Ala 
    690                 695                 700                 


His Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe Thr Ala Lys Phe 
705                 710                 715                 720 


Pro Leu Cys Met Val Phe His Ile Ile Asp Leu Leu Leu Cys Glu Gly 
                725                 730                 735     


Leu Asn Ile Ile Phe His Val Ala Leu Ala Leu Leu Lys Thr Ser Lys 
            740                 745                 750         


Glu Asp Leu Leu Gln Ala Asp Phe Glu Gly Ala Leu Lys Phe Phe Arg 
        755                 760                 765             


Val Gln Leu Pro Lys Arg Tyr Arg Ala Glu Glu Asn Ala Arg Arg Leu 
    770                 775                 780                 


Met Glu Gln Ala Cys Asn Ile Lys Val Pro Thr Lys Lys Leu Lys Lys 
785                 790                 795                 800 


Tyr Glu Lys Glu Tyr Gln Thr Met Arg Glu Ser Gln Leu Gln Gln Glu 
                805                 810                 815     


Asp Pro Met Asp Arg Tyr Lys Phe Phe Phe Leu 
            820                 825         


<210> 6128
<211> 859
<212> PRT
<213> Homo sapiens

<400> 6128
Met Gly Asn Arg Glu Met Glu Glu Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Leu Gly Gln Ser Cys Leu Leu Glu Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Thr Ser Lys Ala Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Asp Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Met Asn 
            100                 105                 110         


Lys Gly Ile Ser Ser Ile Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Glu Met Ile 
145                 150                 155                 160 


Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val Thr Pro 
                165                 170                 175     


Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu His Glu Val Glu Ala Tyr Lys Asn Phe Lys Pro Glu 
305                 310                 315                 320 


Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
            340                 345                 350         


Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Ile Val Lys Lys Gln 
                405                 410                 415     


Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu Val Ile 
            420                 425                 430         


Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Lys Leu Ala Asn 
        435                 440                 445             


Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Thr Thr Val 
            500                 505                 510         


Gly Asn Gln Val Ile Arg Lys Gly Trp Leu Thr Ile Ser Asn Ile Gly 
        515                 520                 525             


Ile Met Lys Gly Gly Ser Lys Gly Tyr Trp Phe Val Leu Thr Ala Glu 
    530                 535                 540                 


Ser Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met 
545                 550                 555                 560 


Leu Pro Leu Asp Asn Leu Lys Val Arg Asp Val Glu Lys Ser Phe Met 
                565                 570                 575     


Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu Gln Arg Asn Val 
            580                 585                 590         


Tyr Lys Asp Tyr Arg Phe Leu Glu Leu Ala Cys Asp Ser Gln Glu Asp 
        595                 600                 605             


Val Asp Ser Trp Lys Ala Ser Leu Leu Arg Ala Gly Val Tyr Pro Asp 
    610                 615                 620                 


Lys Ser Val Ala Glu Asn Asp Glu Asn Gly Gln Ala Glu Asn Phe Ser 
625                 630                 635                 640 


Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg Asn Leu Val 
                645                 650                 655     


Asp Ser Tyr Met Ser Ile Ile Asn Lys Cys Ile Arg Asp Leu Ile Pro 
            660                 665                 670         


Lys Thr Ile Met His Leu Met Ile Asn Asn Val Lys Asp Phe Ile Asn 
        675                 680                 685             


Ser Glu Leu Leu Ala Gln Leu Tyr Ser Ser Glu Asp Gln Asn Thr Leu 
    690                 695                 700                 


Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp Glu Met Leu Arg 
705                 710                 715                 720 


Met Tyr Gln Ala Leu Lys Glu Ala Leu Gly Ile Ile Gly Asp Ile Ser 
                725                 730                 735     


Thr Ala Thr Val Ser Thr Pro Ala Pro Pro Pro Val Asp Asp Ser Trp 
            740                 745                 750         


Ile Gln His Ser Arg Arg Ser Pro Pro Pro Ser Pro Thr Thr Gln Arg 
        755                 760                 765             


Arg Pro Thr Leu Ser Ala Pro Leu Ala Arg Pro Thr Ser Gly Arg Gly 
    770                 775                 780                 


Pro Ala Pro Ala Ile Pro Ser Pro Gly Pro His Ser Gly Ala Pro Pro 
785                 790                 795                 800 


Val Pro Phe Arg Pro Gly Pro Leu Pro Pro Phe Pro Ser Ser Ser Asp 
                805                 810                 815     


Ser Phe Gly Ala Pro Pro Gln Val Pro Ser Arg Pro Thr Arg Ala Pro 
            820                 825                 830         


Pro Ser Val Pro Ser Arg Arg Pro Pro Pro Ser Pro Thr Arg Pro Thr 
        835                 840                 845             


Ile Ile Arg Pro Leu Glu Ser Ser Leu Leu Asp 
    850                 855                 


<210> 6129
<211> 586
<212> PRT
<213> Homo sapiens

<400> 6129
Ser Glu Ser Leu Ser Ser Ala Val Phe Val Glu Gly Leu Lys Arg Gln 
1               5                   10                  15      


Gly Gly Cys Ala Arg Leu Glu Glu Ala Cys Leu Ser Glu Ala Gly Glu 
            20                  25                  30          


Asp Leu Thr Gly Val Arg Phe Ser Leu Pro Gly Lys Asn Phe Pro Cys 
        35                  40                  45              


Gly Ser Ser Ser Ser Ser Ser Arg Ser Arg Asn Ser Ser Ser Ser Asn 
    50                  55                  60                  


Ser Ser Ser Ser Ser Ser Thr Thr Thr Thr Thr Thr Ser Ser Ser Gly 
65                  70                  75                  80  


Ala Gln Asp Arg Met Pro Val Leu Glu Arg Tyr Phe His Pro Ala Glu 
                85                  90                  95      


Leu Gly Arg Arg Trp Thr Gly Pro Glu Gly Val Leu Pro Ser Ser Pro 
            100                 105                 110         


Gly Ser Arg Pro Gly Cys Gln Gln Gly Pro Leu Pro Trp Asp Leu Pro 
        115                 120                 125             


Glu Met Ile Arg Met Val Lys Leu Val Trp Lys Ser Lys Ser Glu Leu 
    130                 135                 140                 


Gln Ala Thr Lys Gln Arg Gly Ile Leu Asp Asn Glu Asp Ala Leu Arg 
145                 150                 155                 160 


Ser Phe Pro Gly Asp Ile Arg Leu Arg Gly Gln Thr Gly Val Arg Ala 
                165                 170                 175     


Glu Arg Arg Gly Ser Tyr Pro Phe Ile Asp Phe Arg Leu Leu Asn Ser 
            180                 185                 190         


Thr Thr Tyr Ser Gly Glu Ile Gly Thr Lys Lys Lys Val Lys Arg Leu 
        195                 200                 205             


Leu Ser Phe Gln Arg Tyr Phe His Ala Ser Arg Leu Leu Arg Gly Ile 
    210                 215                 220                 


Ile Pro Gln Ala Pro Leu His Leu Leu Asp Glu Asp Tyr Leu Gly Gln 
225                 230                 235                 240 


Ala Arg His Met Leu Ser Lys Val Gly Met Trp Asp Phe Asp Ile Phe 
                245                 250                 255     


Leu Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Thr Leu Leu Cys 
            260                 265                 270         


His Leu Phe Asn Thr His Gly Leu Ile His His Phe Lys Leu Asp Met 
        275                 280                 285             


Val Thr Leu His Arg Phe Leu Val Met Val Gln Glu Asp Tyr His Ser 
    290                 295                 300                 


Gln Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala 
305                 310                 315                 320 


Met His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Ser Phe Leu Thr Pro 
                325                 330                 335     


Leu Asp Ile Met Leu Gly Leu Leu Ala Ala Ala Ala His Asp Val Asp 
            340                 345                 350         


His Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His His Leu 
        355                 360                 365             


Ala Asn Leu Tyr Gln Asn Met Ser Val Leu Glu Asn His His Trp Arg 
    370                 375                 380                 


Ser Thr Ile Gly Met Leu Arg Glu Ser Arg Leu Leu Ala His Leu Pro 
385                 390                 395                 400 


Lys Glu Met Thr Gln Asp Ile Glu Gln Gln Leu Gly Ser Leu Ile Leu 
                405                 410                 415     


Ala Thr Asp Ile Asn Arg Gln Asn Glu Phe Leu Thr Arg Leu Lys Ala 
            420                 425                 430         


His Leu His Asn Lys Asp Leu Arg Leu Glu Asp Ala Gln Asp Arg His 
        435                 440                 445             


Phe Met Leu Gln Ile Ala Leu Lys Cys Ala Asp Ile Cys Asn Pro Cys 
    450                 455                 460                 


Arg Ile Trp Glu Met Ser Lys Gln Trp Ser Glu Arg Val Cys Glu Glu 
465                 470                 475                 480 


Phe Tyr Arg Gln Gly Glu Leu Glu Gln Lys Phe Glu Leu Glu Ile Ser 
                485                 490                 495     


Pro Leu Cys Asn Gln Gln Lys Asp Ser Ile Pro Ser Ile Gln Ile Gly 
            500                 505                 510         


Phe Met Ser Tyr Ile Val Glu Pro Leu Phe Arg Glu Trp Ala His Phe 
        515                 520                 525             


Thr Gly Asn Ser Thr Leu Ser Glu Asn Met Leu Gly His Leu Ala His 
    530                 535                 540                 


Asn Lys Ala Gln Trp Lys Ser Leu Leu Pro Arg Gln His Arg Ser Arg 
545                 550                 555                 560 


Gly Ser Ser Gly Ser Gly Pro Asp His Asp His Ala Gly Gln Gly Thr 
                565                 570                 575     


Glu Ser Glu Glu Gln Glu Gly Asp Ser Pro 
            580                 585     


<210> 6130
<211> 174
<212> PRT
<213> Homo sapiens

<400> 6130
Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Arg Arg Ala 
145                 150                 155                 160 


Leu Ile Asp Lys Met Ser Thr Thr Leu Tyr Val Trp Thr Phe 
                165                 170                 


<210> 6131
<211> 400
<212> PRT
<213> Homo sapiens

<400> 6131
Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Thr Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Thr Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu Leu Ser Glu Arg Glu Gln 
                245                 250                 255     


Phe Arg Gln Glu Met Ile Ala Thr Gln Lys Leu Leu Glu Glu Leu Leu 
            260                 265                 270         


Val Ser Leu Gln Trp Gly Arg Glu Gln Thr Tyr Ser Pro Ser Val Gln 
        275                 280                 285             


Pro His Ser Thr Ala Glu Leu Ala Leu Thr Asn His Lys Leu Ala Lys 
    290                 295                 300                 


Ala Val Asn Ser His Leu Leu Gly Asn Val Gly Ile Asn Asn Gln Lys 
305                 310                 315                 320 


Lys Ile Pro Ser Thr Val Glu Phe Cys Ser Thr Pro Ala Glu Lys Met 
                325                 330                 335     


Ala Glu Thr Val Leu Arg Ile Leu Asp Pro Val Thr Cys Lys Glu Ser 
            340                 345                 350         


Ser Pro Asp Asn Pro Phe Phe Glu Ser Ser Pro Thr Thr Leu Leu Ala 
        355                 360                 365             


Thr Lys Lys Asn Ile Gly Arg Phe His Pro Tyr Thr Arg Tyr Glu Asn 
    370                 375                 380                 


Ile Thr Phe Asn Cys Cys Asn His Cys Arg Gly Glu Leu Ile Ala Leu 
385                 390                 395                 400 


<210> 6132
<211> 91
<212> PRT
<213> Homo sapiens

<400> 6132
Met Asp Ala Asp Ser Asp Val Ala Leu Asp Ile Leu Ile Thr Asn Val 
1               5                   10                  15      


Val Cys Val Phe Arg Thr Arg Cys His Leu Asn Leu Arg Lys Ile Ala 
            20                  25                  30          


Leu Glu Gly Ala Asn Val Ile Tyr Lys Arg Asp Val Gly Lys Val Leu 
        35                  40                  45              


Met Lys Leu Arg Lys Pro Arg Ile Thr Ala Thr Ile Trp Ser Ser Gly 
    50                  55                  60                  


Lys Ile Ile Cys Thr Gly Ala Thr Ser Glu Glu Glu Ala Lys Phe Gly 
65                  70                  75                  80  


Ala Arg Arg Leu Ala Arg Ser Leu Gln Lys Leu 
                85                  90      


<210> 6133
<211> 163
<212> PRT
<213> Homo sapiens

<400> 6133
Met Asp Ala Asp Ser Asp Val Ala Leu Asp Ile Leu Ile Thr Asn Val 
1               5                   10                  15      


Val Cys Val Phe Arg Thr Arg Cys His Leu Asn Leu Arg Lys Ile Ala 
            20                  25                  30          


Leu Glu Gly Ala Asn Val Ile Tyr Lys Arg Asp Val Gly Lys Val Leu 
        35                  40                  45              


Met Lys Leu Arg Lys Pro Arg Ile Thr Ala Thr Ile Trp Ser Ser Gly 
    50                  55                  60                  


Lys Ile Ile Cys Thr Gly Ala Thr Ser Glu Glu Glu Ala Lys Phe Gly 
65                  70                  75                  80  


Ala Arg Arg Leu Ala Arg Ser Leu Gln Lys Leu Gly Phe Gln Val Ile 
                85                  90                  95      


Phe Thr Asp Phe Lys Val Val Asn Val Leu Ala Val Cys Asn Met Pro 
            100                 105                 110         


Phe Glu Ile Arg Leu Pro Glu Phe Thr Lys Asn Asn Arg Pro His Ala 
        115                 120                 125             


Ser Tyr Glu Pro Glu Leu His Pro Ala Val Cys Tyr Arg Ile Lys Ser 
    130                 135                 140                 


Leu Arg Ala Thr Leu Gln Ile Phe Ser Thr Gly Ser Ile Thr Val Thr 
145                 150                 155                 160 


Gly Ile Leu 
            


<210> 6134
<211> 340
<212> PRT
<213> Homo sapiens

<400> 6134
Met Leu Glu Ala Pro Gly Pro Ser Asp Gly Cys Glu Leu Ser Asn Pro 
1               5                   10                  15      


Ser Ala Ser Arg Val Ser Cys Ala Gly Gln Met Leu Glu Val Gln Pro 
            20                  25                  30          


Gly Leu Tyr Phe Gly Gly Ala Ala Ala Val Ala Glu Pro Asp His Leu 
        35                  40                  45              


Arg Glu Ala Gly Ile Thr Ala Val Leu Thr Val Asp Ser Glu Glu Pro 
    50                  55                  60                  


Ser Phe Lys Ala Gly Pro Gly Val Glu Asp Leu Trp Arg Leu Phe Val 
65                  70                  75                  80  


Pro Ala Leu Asp Lys Pro Glu Thr Asp Leu Leu Ser His Leu Asp Arg 
                85                  90                  95      


Cys Val Ala Phe Ile Gly Gln Ala Arg Ala Glu Gly Arg Ala Val Leu 
            100                 105                 110         


Val His Cys His Ala Gly Val Ser Arg Ser Val Ala Ile Ile Thr Ala 
        115                 120                 125             


Phe Leu Met Lys Thr Asp Gln Leu Pro Phe Glu Lys Ala Tyr Glu Lys 
    130                 135                 140                 


Leu Gln Ile Leu Lys Pro Glu Ala Lys Met Asn Glu Gly Phe Glu Trp 
145                 150                 155                 160 


Gln Leu Lys Leu Tyr Gln Ala Met Gly Tyr Glu Val Asp Thr Ser Ser 
                165                 170                 175     


Ala Ile Tyr Lys Gln Tyr Arg Leu Gln Lys Val Thr Glu Lys Tyr Pro 
            180                 185                 190         


Glu Leu Gln Asn Leu Pro Gln Glu Leu Phe Ala Val Asp Pro Thr Thr 
        195                 200                 205             


Val Ser Gln Gly Leu Lys Asp Glu Val Leu Tyr Lys Cys Arg Lys Cys 
    210                 215                 220                 


Arg Arg Ser Leu Phe Arg Ser Ser Ser Ile Leu Asp His Arg Glu Gly 
225                 230                 235                 240 


Ser Gly Pro Ile Ala Phe Ala His Lys Arg Met Thr Pro Ser Ser Met 
                245                 250                 255     


Leu Thr Thr Gly Arg Gln Ala Gln Cys Thr Ser Tyr Phe Ile Glu Pro 
            260                 265                 270         


Val Gln Trp Met Glu Ser Ala Leu Leu Gly Val Met Asp Gly Gln Leu 
        275                 280                 285             


Leu Cys Pro Lys Cys Ser Ala Lys Leu Gly Ser Phe Asn Trp Tyr Gly 
    290                 295                 300                 


Glu Gln Cys Ser Cys Gly Arg Trp Ile Thr Pro Ala Phe Gln Ile His 
305                 310                 315                 320 


Lys Asn Arg Val Asp Glu Met Lys Ile Leu Pro Val Leu Gly Ser Gln 
                325                 330                 335     


Thr Gly Lys Ile 
            340 


<210> 6135
<211> 268
<212> PRT
<213> Homo sapiens

<400> 6135
Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Ala Thr Leu Glu Lys Pro 
1               5                   10                  15      


Ile Leu Ser Leu His Pro Pro Trp Thr Thr Ile Phe Lys Gly Glu Arg 
            20                  25                  30          


Val Thr Leu Lys Cys Asp Gly Tyr His Pro Leu Leu Leu Glu Leu Gln 
        35                  40                  45              


Pro Ile Ser Thr Leu Trp Tyr Leu Gly His Leu Leu Leu Pro Ser His 
    50                  55                  60                  


Lys Lys Ser Ile Glu Val Gln Thr Pro Gly Val Tyr Arg Cys Gln Thr 
65                  70                  75                  80  


Arg Gly Ala Pro Val Ser Asp Pro Ile His Leu Ser Val Ser Asn Asp 
                85                  90                  95      


Trp Leu Ile Leu Gln Val Pro Tyr Ala Pro Val Phe Glu Gly Glu Pro 
            100                 105                 110         


Leu Val Leu Arg Cys Arg Gly Trp Tyr Asp Lys Val Val Tyr Lys Leu 
        115                 120                 125             


His Tyr Tyr His Asp Gly Gln Ala Val Arg Tyr Phe His Ser Ser Ala 
    130                 135                 140                 


Asn Tyr Thr Val Leu Gln Ala Arg Ala Ser Asp Ser Gly Arg Tyr Gln 
145                 150                 155                 160 


Cys Ser Gly Thr Met Arg Ile Pro Val Glu Ser Ala Pro Met Phe Ser 
                165                 170                 175     


Ala Lys Val Ala Val Thr Val Gln Glu Ala Arg His Ala Ala Ala Val 
            180                 185                 190         


Arg Val Leu Gln Val Gln Pro Arg Gly Ala Pro Leu Arg Leu Gly Arg 
        195                 200                 205             


Arg Val His Ser Pro Gly Ala Arg Gly Arg Gly Ala Arg Ile Val Leu 
    210                 215                 220                 


Val Arg Gly Gly Tyr Arg His Pro Gln Cys Pro Glu Thr Gln Ser Val 
225                 230                 235                 240 


Ala Ala Ala Pro Gly Ala Gly Phe Ser Pro Gly Pro Gly Leu His His 
                245                 250                 255     


Arg Pro Ser Ser Met Gly Arg Ser Leu Gly Ser Trp 
            260                 265             


<210> 6136
<211> 311
<212> PRT
<213> Homo sapiens

<400> 6136
Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Ala Thr Leu Glu Lys Pro 
1               5                   10                  15      


Ile Leu Ser Leu His Pro Pro Trp Thr Thr Ile Phe Lys Gly Glu Arg 
            20                  25                  30          


Val Thr Leu Lys Cys Asp Gly Tyr His Pro Leu Leu Leu Glu Leu Gln 
        35                  40                  45              


Pro Ile Ser Thr Leu Trp Tyr Leu Gly His Leu Leu Leu Pro Ser His 
    50                  55                  60                  


Lys Lys Ser Ile Glu Val Gln Thr Pro Gly Val Tyr Arg Cys Gln Thr 
65                  70                  75                  80  


Arg Gly Ala Pro Val Ser Asp Pro Ile His Leu Ser Val Ser Asn Asp 
                85                  90                  95      


Trp Leu Ile Leu Gln Val Pro Tyr Ala Pro Val Phe Glu Gly Glu Pro 
            100                 105                 110         


Leu Val Leu Arg Cys Arg Gly Trp Tyr Asp Lys Val Val Tyr Lys Leu 
        115                 120                 125             


His Tyr Tyr His Asp Gly Gln Ala Val Arg Tyr Phe His Ser Ser Ala 
    130                 135                 140                 


Asn Tyr Thr Val Leu Gln Ala Arg Ala Ser Asp Ser Gly Arg Tyr Gln 
145                 150                 155                 160 


Cys Ser Gly Thr Met Arg Ile Pro Val Glu Ser Ala Pro Met Phe Ser 
                165                 170                 175     


Ala Lys Val Ala Val Thr Val Gln Ala Ala Arg Cys Ala Ala Ser Thr 
            180                 185                 190         


Gly Ala Pro Ser Thr Gln Ser Arg Ser Pro Arg Ser Arg Ser Ser Asn 
        195                 200                 205             


Arg Thr Gly Ala Arg Arg Leu Pro Pro Pro Ala Val Ser Gly Asn Ala 
    210                 215                 220                 


Val Arg Gly Cys Ser Ser Arg Gly Arg Val Leu Pro Trp Thr Arg Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gln Leu His Gly Pro Gln Pro Trp Leu Leu Val Ile 
                245                 250                 255     


Gly Arg Phe Pro Ser Glu Ser Pro Arg Cys Pro Asp Arg Ser Arg Trp 
            260                 265                 270         


Ser Pro Pro Ser Gly Thr Pro Pro Pro Pro Gly Cys Ser Ser Arg Arg 
        275                 280                 285             


Ala Ala Pro Arg Leu Arg Gly His Pro Pro Ala Leu Arg Arg Arg Pro 
    290                 295                 300                 


Trp Asn Asn Arg Leu Glu Pro 
305                 310     


<210> 6137
<211> 318
<212> PRT
<213> Homo sapiens

<400> 6137
Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Ala 
            180                 185                 190         


Ala Arg Cys Ala Ala Ser Thr Gly Ala Pro Ser Thr Gln Ser Arg Ser 
        195                 200                 205             


Pro Arg Ser Arg Ser Ser Asn Arg Thr Gly Ala Arg Arg Leu Pro Pro 
    210                 215                 220                 


Pro Ala Val Ser Gly Asn Ala Val Arg Gly Cys Ser Ser Arg Gly Arg 
225                 230                 235                 240 


Val Leu Pro Trp Thr Arg Pro Pro Pro Pro Pro Gln Leu His Gly Pro 
                245                 250                 255     


Gln Pro Trp Leu Leu Val Ile Gly Arg Phe Pro Ser Glu Ser Pro Arg 
            260                 265                 270         


Cys Pro Asp Arg Ser Arg Trp Ser Pro Pro Ser Gly Thr Pro Pro Pro 
        275                 280                 285             


Pro Gly Cys Ser Ser Arg Arg Ala Ala Pro Arg Leu Arg Gly His Pro 
    290                 295                 300                 


Pro Ala Leu Arg Arg Arg Pro Trp Asn Asn Arg Leu Glu Pro 
305                 310                 315             


<210> 6138
<211> 426
<212> PRT
<213> Homo sapiens

<400> 6138
Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Glu 
            180                 185                 190         


Leu Phe Arg Ala Pro Val Leu Arg Val Met Gly Pro Arg Glu Ala Arg 
        195                 200                 205             


Gly Ala Ala Leu Gly Gly Val Val Leu Arg Cys Asp Thr Arg Leu His 
    210                 215                 220                 


Pro Gln Lys Arg Asp Thr Pro Leu Gln Phe Ala Phe Tyr Lys Tyr Ser 
225                 230                 235                 240 


Arg Ala Val Arg Arg Phe Asp Trp Gly Ala Glu Tyr Thr Val Pro Glu 
                245                 250                 255     


Pro Glu Val Glu Glu Leu Glu Ser Tyr Trp Cys Glu Ala Ala Thr Ala 
            260                 265                 270         


Thr Arg Ser Val Arg Lys Arg Ser Pro Trp Leu Gln Leu Pro Gly Pro 
        275                 280                 285             


Gly Ser Pro Leu Asp Pro Ala Ser Thr Thr Ala Pro Ala Pro Trp Ala 
    290                 295                 300                 


Ala Ala Leu Ala Pro Gly Asn Arg Pro Leu Ser Phe Arg Lys Pro Pro 
305                 310                 315                 320 


Val Ser Arg Ser Val Pro Leu Val Thr Ser Val Arg Asn Thr Thr Ser 
                325                 330                 335     


Thr Gly Leu Gln Phe Pro Ala Ser Gly Ala Pro Thr Ala Gly Pro Pro 
            340                 345                 350         


Ala Cys Ala Pro Pro Thr Pro Leu Glu Gln Ser Ala Gly Ala Leu Lys 
        355                 360                 365             


Pro Asp Val Asp Leu Leu Leu Arg Glu Met Gln Leu Leu Lys Gly Leu 
    370                 375                 380                 


Leu Ser Arg Val Val Leu Glu Leu Lys Glu Pro Gln Ala Leu Arg Glu 
385                 390                 395                 400 


Leu Arg Gly Thr Pro Glu Thr Pro Thr Ser His Phe Ala Val Ser Pro 
                405                 410                 415     


Gly Thr Pro Glu Thr Thr Pro Val Glu Ser 
            420                 425     


<210> 6139
<211> 122
<212> PRT
<213> Homo sapiens

<400> 6139
Met Ala Gly Gly Cys Arg Ala Pro Ser Ser Ala Pro Thr Val Ser Leu 
1               5                   10                  15      


Pro Glu Leu Arg Ser Leu Leu Ala Ser Gly Arg Ala Arg Leu Phe Asp 
            20                  25                  30          


Val Arg Ser Arg Glu Glu Ala Ala Ala Gly Thr Ile Pro Gly Ala Leu 
        35                  40                  45              


Asn Ile Pro Val Ser Glu Leu Glu Ser Ala Leu Gln Met Glu Pro Ala 
    50                  55                  60                  


Ala Phe Gln Ala Leu Tyr Ser Ala Glu Lys Pro Lys Leu Glu Asp Glu 
65                  70                  75                  80  


His Leu Val Phe Phe Cys Gln Met Gly Lys Arg Gly Leu Gln Ala Thr 
                85                  90                  95      


Gln Leu Ala Arg Ser Leu Gly Tyr Thr Gly Ala Arg Asn Tyr Ala Gly 
            100                 105                 110         


Ala Tyr Arg Glu Trp Leu Glu Lys Glu Ser 
        115                 120         


<210> 6140
<211> 74
<212> PRT
<213> Homo sapiens

<400> 6140
Met Ala Gly Val Ser Glu Leu Glu Ser Ala Leu Gln Met Glu Pro Ala 
1               5                   10                  15      


Ala Phe Gln Ala Leu Tyr Ser Ala Glu Lys Pro Lys Leu Glu Asp Glu 
            20                  25                  30          


His Leu Val Phe Phe Cys Gln Met Gly Lys Arg Gly Leu Gln Ala Thr 
        35                  40                  45              


Gln Leu Ala Arg Ser Leu Gly Tyr Thr Gly Ala Arg Asn Tyr Ala Gly 
    50                  55                  60                  


Ala Tyr Arg Glu Trp Leu Glu Lys Glu Ser 
65                  70                  


<210> 6141
<211> 597
<212> PRT
<213> Homo sapiens

<400> 6141
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Thr Glu Ser 
    50                  55                  60                  


Arg Gly Thr Asp Thr Glu Ser Ser Gly Glu Asp Lys Asp Ser Asp Ser 
65                  70                  75                  80  


Met Glu Asp Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His 
                85                  90                  95      


Asp Arg Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Gln Pro Arg Arg Arg Val Gln Arg Lys Arg Ala Asn Arg Asp Gln Asp 
        115                 120                 125             


Ser Ser Asp Asp Glu Arg Ala Leu Glu Asp Trp Val Ser Ser Glu Thr 
    130                 135                 140                 


Ser Ala Leu Pro Arg Pro Arg Trp Gln Ala Leu Pro Ala Leu Arg Glu 
145                 150                 155                 160 


Arg Glu Leu Gly Ser Ser Ala Arg Phe Val Tyr Glu Ala Cys Gly Ala 
                165                 170                 175     


Arg Val Phe Val Gln Arg Phe Arg Leu Gln His Gly Leu Glu Gly His 
            180                 185                 190         


Thr Gly Cys Val Asn Thr Leu His Phe Asn Gln Arg Gly Thr Trp Leu 
        195                 200                 205             


Ala Ser Gly Ser Asp Asp Leu Lys Val Val Val Trp Asp Trp Val Arg 
    210                 215                 220                 


Arg Gln Pro Val Leu Asp Phe Glu Ser Gly His Lys Ser Asn Val Phe 
225                 230                 235                 240 


Gln Ala Lys Phe Leu Pro Asn Ser Gly Asp Ser Thr Leu Ala Met Cys 
                245                 250                 255     


Ala Arg Asp Gly Gln Val Arg Val Ala Glu Leu Ser Ala Thr Gln Cys 
            260                 265                 270         


Cys Lys Asn Thr Lys Arg Val Ala Gln His Lys Gly Ala Ser His Lys 
        275                 280                 285             


Leu Ala Leu Glu Pro Asp Ser Pro Cys Thr Phe Leu Ser Ala Gly Glu 
    290                 295                 300                 


Asp Ala Val Val Phe Thr Ile Asp Leu Arg Gln Asp Arg Pro Ala Ser 
305                 310                 315                 320 


Lys Leu Val Val Thr Lys Glu Lys Glu Lys Lys Val Gly Leu Tyr Thr 
                325                 330                 335     


Ile Tyr Val Asn Pro Ala Asn Thr His Gln Phe Ala Val Gly Gly Arg 
            340                 345                 350         


Asp Gln Phe Val Arg Ile Tyr Asp Gln Arg Lys Ile Asp Glu Asn Glu 
        355                 360                 365             


Asn Asn Gly Val Leu Lys Lys Phe Cys Pro His His Leu Val Asn Ser 
    370                 375                 380                 


Glu Ser Lys Ala Asn Ile Thr Cys Leu Val Tyr Ser His Asp Gly Thr 
385                 390                 395                 400 


Glu Leu Leu Ala Ser Tyr Asn Asp Glu Asp Ile Tyr Leu Phe Asn Ser 
                405                 410                 415     


Ser His Ser Asp Gly Ala Gln Tyr Val Lys Arg Tyr Lys Gly His Arg 
            420                 425                 430         


Asn Asn Ala Thr Val Lys Gly Val Asn Phe Tyr Gly Pro Lys Ser Glu 
        435                 440                 445             


Phe Val Val Ser Gly Ser Asp Cys Gly His Ile Phe Leu Trp Glu Lys 
    450                 455                 460                 


Ser Ser Cys Gln Ile Ile Gln Phe Met Glu Gly Asp Lys Gly Gly Val 
465                 470                 475                 480 


Val Asn Cys Leu Glu Pro His Pro His Leu Pro Val Leu Ala Thr Ser 
                485                 490                 495     


Gly Leu Asp His Asp Val Lys Ile Trp Ala Pro Thr Ala Glu Ala Ser 
            500                 505                 510         


Thr Glu Leu Thr Gly Leu Lys Asp Val Ile Lys Lys Asn Lys Arg Glu 
        515                 520                 525             


Arg Asp Glu Asp Ser Leu His Gln Thr Asp Leu Phe Asp Ser His Met 
    530                 535                 540                 


Leu Trp Phe Leu Met His His Leu Arg Gln Arg Arg His His Arg Arg 
545                 550                 555                 560 


Trp Arg Glu Pro Gly Val Gly Ala Thr Asp Ala Asp Ser Asp Glu Ser 
                565                 570                 575     


Pro Ser Ser Ser Asp Thr Ser Asp Glu Glu Glu Gly Pro Asp Arg Val 
            580                 585                 590         


Gln Cys Met Pro Ser 
        595         


<210> 6142
<211> 597
<212> PRT
<213> Homo sapiens

<400> 6142
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Thr Glu Ser 
    50                  55                  60                  


Arg Gly Thr Asp Thr Glu Ser Ser Gly Glu Asp Lys Asp Ser Asp Ser 
65                  70                  75                  80  


Met Glu Asp Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His 
                85                  90                  95      


Asp Arg Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Gln Pro Arg Arg Arg Val Gln Arg Lys Arg Ala Asn Arg Asp Gln Asp 
        115                 120                 125             


Ser Ser Asp Asp Glu Arg Ala Leu Glu Asp Trp Val Ser Ser Glu Thr 
    130                 135                 140                 


Ser Ala Leu Pro Arg Pro Arg Trp Gln Ala Leu Pro Ala Leu Arg Glu 
145                 150                 155                 160 


Arg Glu Leu Gly Ser Ser Ala Arg Phe Val Tyr Glu Ala Cys Gly Ala 
                165                 170                 175     


Arg Val Phe Val Gln Arg Phe Arg Leu Gln His Gly Leu Glu Gly His 
            180                 185                 190         


Thr Gly Cys Val Asn Thr Leu His Phe Asn Gln Arg Gly Thr Trp Leu 
        195                 200                 205             


Ala Ser Gly Ser Asp Asp Leu Lys Val Val Val Trp Asp Trp Val Arg 
    210                 215                 220                 


Arg Gln Pro Val Leu Asp Phe Glu Ser Gly His Lys Ser Asn Val Phe 
225                 230                 235                 240 


Gln Ala Lys Phe Leu Pro Asn Ser Gly Asp Ser Thr Leu Ala Met Cys 
                245                 250                 255     


Ala Arg Asp Gly Gln Val Arg Val Ala Glu Leu Ser Ala Thr Gln Cys 
            260                 265                 270         


Cys Lys Asn Thr Lys Arg Val Ala Gln His Lys Gly Ala Ser His Lys 
        275                 280                 285             


Leu Ala Leu Glu Pro Asp Ser Pro Cys Thr Phe Leu Ser Ala Gly Glu 
    290                 295                 300                 


Asp Ala Val Val Phe Thr Ile Asp Leu Arg Gln Asp Arg Pro Ala Ser 
305                 310                 315                 320 


Lys Leu Val Val Thr Lys Glu Lys Glu Lys Lys Val Gly Leu Tyr Thr 
                325                 330                 335     


Ile Tyr Val Asn Pro Ala Asn Thr His Gln Phe Ala Val Gly Gly Arg 
            340                 345                 350         


Asp Gln Phe Val Arg Ile Tyr Asp Gln Arg Lys Ile Asp Glu Asn Glu 
        355                 360                 365             


Asn Asn Gly Val Leu Lys Lys Phe Cys Pro His His Leu Val Asn Ser 
    370                 375                 380                 


Glu Ser Lys Ala Asn Ile Thr Cys Leu Val Tyr Ser His Asp Gly Thr 
385                 390                 395                 400 


Glu Leu Leu Ala Ser Tyr Asn Asp Glu Asp Ile Tyr Leu Phe Asn Ser 
                405                 410                 415     


Ser His Ser Asp Gly Ala Gln Tyr Val Lys Arg Tyr Lys Gly His Arg 
            420                 425                 430         


Asn Asn Ala Thr Val Lys Gly Val Asn Phe Tyr Gly Pro Lys Ser Glu 
        435                 440                 445             


Phe Val Val Ser Gly Ser Asp Cys Gly His Ile Phe Leu Trp Glu Lys 
    450                 455                 460                 


Ser Ser Cys Gln Ile Ile Gln Phe Met Glu Gly Asp Lys Gly Gly Val 
465                 470                 475                 480 


Val Asn Cys Leu Glu Pro His Pro His Leu Pro Val Leu Ala Thr Ser 
                485                 490                 495     


Gly Leu Asp His Asp Val Lys Ile Trp Ala Pro Thr Ala Glu Ala Ser 
            500                 505                 510         


Thr Glu Leu Thr Gly Leu Lys Asp Val Ile Lys Lys Asn Lys Arg Glu 
        515                 520                 525             


Arg Asp Glu Asp Ser Leu His Gln Thr Asp Leu Phe Asp Ser His Met 
    530                 535                 540                 


Leu Trp Phe Leu Met His His Leu Arg Gln Arg Arg His His Arg Arg 
545                 550                 555                 560 


Trp Arg Glu Pro Gly Val Gly Ala Thr Asp Ala Asp Ser Asp Glu Ser 
                565                 570                 575     


Pro Ser Ser Ser Asp Thr Ser Asp Glu Glu Glu Gly Pro Asp Arg Val 
            580                 585                 590         


Gln Cys Met Pro Ser 
        595         


<210> 6143
<211> 150
<212> PRT
<213> Homo sapiens

<400> 6143
Met Gly Val Gln Pro Pro Asn Phe Ser Trp Val Leu Pro Gly Arg Leu 
1               5                   10                  15      


Ala Gly Leu Ala Leu Pro Arg Leu Pro Ala His Tyr Gln Phe Leu Leu 
            20                  25                  30          


Asp Leu Gly Val Arg His Leu Val Ser Leu Thr Glu Arg Gly Pro Pro 
        35                  40                  45              


His Ser Asp Ser Cys Pro Gly Leu Thr Leu His Arg Leu Arg Ile Pro 
    50                  55                  60                  


Asp Phe Cys Pro Pro Ala Pro Asp Gln Ile Asp Arg Phe Val Gln Ile 
65                  70                  75                  80  


Val Asp Glu Ala Asn Ala Arg Gly Glu Ala Val Gly Val His Cys Ala 
                85                  90                  95      


Leu Gly Phe Gly Arg Thr Gly Thr Met Leu Ala Cys Tyr Leu Val Lys 
            100                 105                 110         


Glu Arg Gly Leu Ala Ala Gly Asp Ala Ile Ala Glu Ile Arg Arg Leu 
        115                 120                 125             


Arg Pro Gly Ser Ile Glu Thr Tyr Glu Gln Glu Lys Ala Val Phe Gln 
    130                 135                 140                 


Phe Tyr Gln Arg Thr Lys 
145                 150 


<210> 6144
<211> 150
<212> PRT
<213> Homo sapiens

<400> 6144
Met Gly Val Gln Pro Pro Asn Phe Ser Trp Val Leu Pro Gly Arg Leu 
1               5                   10                  15      


Ala Gly Leu Ala Leu Pro Arg Leu Pro Ala His Tyr Gln Phe Leu Leu 
            20                  25                  30          


Asp Leu Gly Val Arg His Leu Val Ser Leu Thr Glu Arg Gly Pro Pro 
        35                  40                  45              


His Ser Asp Ser Cys Pro Gly Leu Thr Leu His Arg Leu Arg Ile Pro 
    50                  55                  60                  


Asp Phe Cys Pro Pro Ala Pro Asp Gln Ile Asp Arg Phe Val Gln Ile 
65                  70                  75                  80  


Val Asp Glu Ala Asn Ala Arg Gly Glu Ala Val Gly Val His Cys Ala 
                85                  90                  95      


Leu Gly Phe Gly Arg Thr Gly Thr Met Leu Ala Cys Tyr Leu Val Lys 
            100                 105                 110         


Glu Arg Gly Leu Ala Ala Gly Asp Ala Ile Ala Glu Ile Arg Arg Leu 
        115                 120                 125             


Arg Pro Gly Ser Ile Glu Thr Tyr Glu Gln Glu Lys Ala Val Phe Gln 
    130                 135                 140                 


Phe Tyr Gln Arg Thr Lys 
145                 150 


<210> 6145
<211> 150
<212> PRT
<213> Homo sapiens

<400> 6145
Met Gly Val Gln Pro Pro Asn Phe Ser Trp Val Leu Pro Gly Arg Leu 
1               5                   10                  15      


Ala Gly Leu Ala Leu Pro Arg Leu Pro Ala His Tyr Gln Phe Leu Leu 
            20                  25                  30          


Asp Leu Gly Val Arg His Leu Val Ser Leu Thr Glu Arg Gly Pro Pro 
        35                  40                  45              


His Ser Asp Ser Cys Pro Gly Leu Thr Leu His Arg Leu Arg Ile Pro 
    50                  55                  60                  


Asp Phe Cys Pro Pro Ala Pro Asp Gln Ile Asp Arg Phe Val Gln Ile 
65                  70                  75                  80  


Val Asp Glu Ala Asn Ala Arg Gly Glu Ala Val Gly Val His Cys Ala 
                85                  90                  95      


Leu Gly Phe Gly Arg Thr Gly Thr Met Leu Ala Cys Tyr Leu Val Lys 
            100                 105                 110         


Glu Arg Gly Leu Ala Ala Gly Asp Ala Ile Ala Glu Ile Arg Arg Leu 
        115                 120                 125             


Arg Pro Gly Ser Ile Glu Thr Tyr Glu Gln Glu Lys Ala Val Phe Gln 
    130                 135                 140                 


Phe Tyr Gln Arg Thr Lys 
145                 150 


<210> 6146
<211> 1621
<212> PRT
<213> Homo sapiens

<400> 6146
Met Glu Gly Cys Met Gly Glu Glu Ser Phe Gln Met Trp Glu Leu Asn 
1               5                   10                  15      


Arg Arg Leu Glu Ala Tyr Leu Ala Arg Val Lys Ala Leu Glu Glu Gln 
            20                  25                  30          


Asn Glu Leu Leu Ser Ala Glu Leu Gly Gly Leu Arg Ala Gln Ser Ala 
        35                  40                  45              


Asp Thr Ser Trp Arg Ala His Ala Asp Asp Glu Leu Ala Ala Leu Arg 
    50                  55                  60                  


Ala Leu Val Asp Gln Arg Trp Arg Glu Lys His Ala Ala Glu Val Ala 
65                  70                  75                  80  


Arg Asp Asn Leu Ala Glu Glu Leu Glu Gly Val Ala Gly Arg Cys Gln 
                85                  90                  95      


Gln Leu Arg Leu Ala Arg Glu Arg Thr Thr Glu Glu Val Ala Arg Asn 
            100                 105                 110         


Arg Arg Ala Val Glu Ala Glu Lys Cys Ala Arg Ala Trp Leu Ser Ser 
        115                 120                 125             


Gln Val Ala Glu Leu Glu Arg Glu Leu Glu Ala Leu Arg Val Ala His 
    130                 135                 140                 


Glu Glu Glu Arg Val Gly Leu Asn Ala Gln Ala Ala Cys Ala Pro Arg 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Arg Gly Pro Pro Ala Pro Ala Pro Glu Val Glu 
                165                 170                 175     


Glu Leu Ala Arg Arg Leu Gly Glu Ala Trp Arg Gly Ala Val Arg Gly 
            180                 185                 190         


Tyr Gln Glu Arg Val Ala His Met Glu Thr Ser Leu Gly Gln Ala Arg 
        195                 200                 205             


Glu Arg Leu Gly Arg Ala Val Gln Gly Ala Arg Glu Gly Arg Leu Glu 
    210                 215                 220                 


Leu Gln Gln Leu Gln Ala Glu Arg Gly Gly Leu Leu Glu Arg Arg Ala 
225                 230                 235                 240 


Ala Leu Glu Gln Arg Leu Glu Gly Arg Trp Gln Glu Arg Leu Arg Ala 
                245                 250                 255     


Thr Glu Lys Phe Gln Leu Ala Val Glu Ala Leu Glu Gln Glu Lys Gln 
            260                 265                 270         


Gly Leu Gln Ser Gln Ile Ala Gln Val Leu Glu Gly Arg Gln Gln Leu 
        275                 280                 285             


Ala His Leu Lys Met Ser Leu Ser Leu Glu Val Ala Thr Tyr Arg Thr 
    290                 295                 300                 


Leu Leu Glu Ala Glu Asn Ser Arg Leu Gln Thr Pro Gly Gly Gly Ser 
305                 310                 315                 320 


Lys Thr Ser Leu Ser Phe Gln Asp Pro Lys Leu Glu Leu Gln Phe Pro 
                325                 330                 335     


Arg Thr Pro Glu Gly Arg Arg Leu Gly Ser Leu Leu Pro Val Leu Ser 
            340                 345                 350         


Pro Thr Ser Leu Pro Ser Pro Leu Pro Ala Thr Leu Glu Thr Pro Val 
        355                 360                 365             


Pro Ala Phe Leu Lys Asn Gln Glu Phe Leu Gln Ala Arg Thr Pro Thr 
    370                 375                 380                 


Leu Ala Ser Thr Pro Ile Pro Pro Thr Pro Gln Ala Pro Ser Pro Ala 
385                 390                 395                 400 


Val Asp Ala Glu Ile Arg Ala Gln Asp Ala Pro Leu Ser Leu Leu Gln 
                405                 410                 415     


Thr Gln Gly Gly Arg Lys Gln Ala Pro Glu Pro Leu Arg Ala Glu Ala 
            420                 425                 430         


Arg Val Ala Ile Pro Ala Ser Val Leu Pro Gly Pro Glu Glu Pro Gly 
        435                 440                 445             


Gly Gln Arg Gln Glu Ala Ser Thr Gly Gln Ser Pro Glu Asp His Ala 
    450                 455                 460                 


Ser Leu Ala Pro Pro Leu Ser Pro Asp His Ser Ser Leu Glu Ala Lys 
465                 470                 475                 480 


Asp Gly Glu Ser Gly Gly Ser Arg Val Phe Ser Ile Cys Arg Gly Glu 
                485                 490                 495     


Gly Glu Gly Gln Ile Trp Gly Leu Val Glu Lys Glu Thr Ala Ile Glu 
            500                 505                 510         


Gly Lys Val Val Ser Ser Leu Gln Gln Glu Ile Trp Glu Glu Glu Asp 
        515                 520                 525             


Leu Asn Arg Lys Glu Ile Gln Asp Ser Gln Val Pro Leu Glu Lys Glu 
    530                 535                 540                 


Thr Leu Lys Ser Leu Gly Glu Glu Ile Gln Glu Ser Leu Lys Thr Leu 
545                 550                 555                 560 


Glu Asn Gln Ser His Glu Thr Leu Glu Arg Glu Asn Gln Glu Cys Pro 
                565                 570                 575     


Arg Ser Leu Glu Glu Asp Leu Glu Thr Leu Lys Ser Leu Glu Lys Glu 
            580                 585                 590         


Asn Lys Glu Leu Leu Lys Asp Val Glu Val Val Arg Pro Leu Glu Lys 
        595                 600                 605             


Glu Ala Val Gly Gln Leu Lys Pro Thr Gly Lys Glu Asp Thr Gln Thr 
    610                 615                 620                 


Leu Gln Ser Leu Gln Lys Glu Asn Gln Glu Leu Met Lys Ser Leu Glu 
625                 630                 635                 640 


Gly Asn Leu Glu Thr Phe Leu Phe Pro Gly Thr Glu Asn Gln Glu Leu 
                645                 650                 655     


Val Ser Ser Leu Gln Glu Asn Leu Glu Ser Leu Thr Ala Leu Glu Lys 
            660                 665                 670         


Glu Asn Gln Glu Pro Leu Arg Ser Pro Glu Val Gly Asp Glu Glu Ala 
        675                 680                 685             


Leu Arg Pro Leu Thr Lys Glu Asn Gln Glu Pro Leu Arg Ser Leu Glu 
    690                 695                 700                 


Asp Glu Asn Lys Glu Ala Phe Arg Ser Leu Glu Lys Glu Asn Gln Glu 
705                 710                 715                 720 


Pro Leu Lys Thr Leu Glu Glu Glu Asp Gln Ser Ile Val Arg Pro Leu 
                725                 730                 735     


Glu Thr Glu Asn His Lys Ser Leu Arg Ser Leu Glu Glu Gln Asp Gln 
            740                 745                 750         


Glu Thr Leu Arg Thr Leu Glu Lys Glu Thr Gln Gln Arg Arg Arg Ser 
        755                 760                 765             


Leu Gly Glu Gln Asp Gln Met Thr Leu Arg Pro Pro Glu Lys Val Asp 
    770                 775                 780                 


Leu Glu Pro Leu Lys Ser Leu Asp Gln Glu Ile Ala Arg Pro Leu Glu 
785                 790                 795                 800 


Asn Glu Asn Gln Glu Phe Leu Lys Ser Leu Lys Glu Glu Ser Val Glu 
                805                 810                 815     


Ala Val Lys Ser Leu Glu Thr Glu Ile Leu Glu Ser Leu Lys Ser Ala 
            820                 825                 830         


Gly Gln Glu Asn Leu Glu Thr Leu Lys Ser Pro Glu Thr Gln Ala Pro 
        835                 840                 845             


Leu Trp Thr Pro Glu Glu Ile Asn Gln Gly Ala Met Asn Pro Leu Glu 
    850                 855                 860                 


Lys Glu Ile Gln Glu Pro Leu Glu Ser Val Glu Val Asn Gln Glu Thr 
865                 870                 875                 880 


Phe Arg Leu Leu Glu Glu Glu Asn Gln Glu Ser Leu Arg Ser Leu Gly 
                885                 890                 895     


Ala Trp Asn Leu Glu Asn Leu Arg Ser Pro Glu Glu Val Asp Lys Glu 
            900                 905                 910         


Ser Gln Arg Asn Leu Glu Glu Glu Glu Asn Leu Gly Lys Gly Glu Tyr 
        915                 920                 925             


Gln Glu Ser Leu Arg Ser Leu Glu Glu Glu Gly Gln Glu Leu Pro Gln 
    930                 935                 940                 


Ser Ala Asp Val Gln Arg Trp Glu Asp Thr Val Glu Lys Asp Gln Glu 
945                 950                 955                 960 


Leu Ala Gln Glu Ser Pro Pro Gly Met Ala Gly Val Glu Asn Glu Asp 
                965                 970                 975     


Glu Ala Glu Leu Asn Leu Arg Glu Gln Asp Gly Phe Thr Gly Lys Glu 
            980                 985                 990         


Glu Val Val Glu Gln Gly Glu Leu  Asn Ala Thr Glu Glu  Val Trp Ile 
        995                 1000                 1005             


Pro Gly  Glu Gly His Pro Glu  Ser Pro Glu Pro Lys  Glu Gln Arg 
    1010                 1015                 1020             


Gly Leu  Val Glu Gly Ala Ser  Val Lys Gly Gly Ala  Glu Gly Leu 
    1025                 1030                 1035             


Gln Asp  Pro Glu Gly Gln Ser  Gln Gln Val Gly Ala  Pro Gly Leu 
    1040                 1045                 1050             


Gln Ala  Pro Gln Gly Leu Pro  Glu Ala Ile Glu Pro  Leu Val Glu 
    1055                 1060                 1065             


Asp Asp  Val Ala Pro Gly Gly  Asp Gln Ala Ser Pro  Glu Val Met 
    1070                 1075                 1080             


Leu Gly  Ser Glu Pro Ala Met  Gly Glu Ser Ala Ala  Gly Ala Glu 
    1085                 1090                 1095             


Pro Gly  Pro Gly Gln Gly Val  Gly Gly Leu Gly Asp  Pro Gly His 
    1100                 1105                 1110             


Leu Thr  Arg Glu Glu Val Met  Glu Pro Pro Leu Glu  Glu Glu Ser 
    1115                 1120                 1125             


Leu Glu  Ala Lys Arg Val Gln  Gly Leu Glu Gly Pro  Arg Lys Asp 
    1130                 1135                 1140             


Leu Glu  Glu Ala Gly Gly Leu  Gly Thr Glu Phe Ser  Glu Leu Pro 
    1145                 1150                 1155             


Gly Lys  Ser Arg Asp Pro Trp  Glu Pro Pro Arg Glu  Gly Arg Glu 
    1160                 1165                 1170             


Glu Ser  Glu Ala Glu Ala Pro  Arg Gly Ala Glu Glu  Ala Phe Pro 
    1175                 1180                 1185             


Ala Glu  Thr Leu Gly His Thr  Gly Ser Asp Ala Pro  Ser Pro Trp 
    1190                 1195                 1200             


Pro Leu  Gly Ser Glu Glu Ala  Glu Glu Asp Val Pro  Pro Val Leu 
    1205                 1210                 1215             


Val Ser  Pro Ser Pro Thr Tyr  Thr Pro Ile Leu Glu  Asp Ala Pro 
    1220                 1225                 1230             


Gly Pro  Gln Pro Gln Ala Glu  Gly Ser Gln Glu Ala  Ser Trp Gly 
    1235                 1240                 1245             


Val Gln  Gly Arg Ala Glu Ala  Leu Gly Lys Val Glu  Ser Glu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Gly Ser Gly Glu  Ile Pro Glu Gly Pro  Gln Glu Glu 
    1265                 1270                 1275             


Gly Glu  Glu Ser Arg Glu Glu  Ser Glu Glu Asp Glu  Leu Gly Glu 
    1280                 1285                 1290             


Thr Leu  Pro Asp Ser Thr Pro  Leu Gly Phe Tyr Leu  Arg Ser Pro 
    1295                 1300                 1305             


Thr Ser  Pro Arg Trp Asp Pro  Thr Gly Glu Gln Arg  Pro Pro Pro 
    1310                 1315                 1320             


Gln Gly  Glu Thr Gly Lys Glu  Gly Trp Asp Pro Ala  Val Leu Ala 
    1325                 1330                 1335             


Ser Glu  Gly Leu Glu Ala Pro  Pro Ser Glu Lys Glu  Glu Gly Glu 
    1340                 1345                 1350             


Glu Gly  Glu Glu Glu Cys Gly  Arg Asp Ser Asp Leu  Ser Glu Glu 
    1355                 1360                 1365             


Phe Glu  Asp Leu Gly Thr Glu  Ala Pro Phe Leu Pro  Gly Val Pro 
    1370                 1375                 1380             


Gly Glu  Val Ala Glu Pro Leu  Gly Gln Val Pro Gln  Leu Leu Leu 
    1385                 1390                 1395             


Asp Pro  Ala Ala Trp Asp Arg  Asp Gly Glu Ser Asp  Gly Phe Ala 
    1400                 1405                 1410             


Asp Glu  Glu Glu Ser Gly Glu  Glu Gly Glu Glu Asp  Gln Glu Glu 
    1415                 1420                 1425             


Gly Arg  Glu Pro Gly Ala Gly  Arg Trp Gly Pro Gly  Ser Ser Val 
    1430                 1435                 1440             


Gly Ser  Leu Gln Ala Leu Ser  Ser Ser Gln Arg Gly  Glu Phe Leu 
    1445                 1450                 1455             


Glu Ser  Asp Ser Val Ser Val  Ser Val Pro Trp Asp  Asp Ser Leu 
    1460                 1465                 1470             


Arg Gly  Ala Val Ala Gly Ala  Pro Lys Thr Ala Leu  Glu Thr Glu 
    1475                 1480                 1485             


Ser Gln  Asp Ser Ala Glu Pro  Ser Gly Ser Glu Glu  Glu Ser Asp 
    1490                 1495                 1500             


Pro Val  Ser Leu Glu Arg Glu  Asp Lys Val Pro Gly  Pro Leu Glu 
    1505                 1510                 1515             


Ile Pro  Ser Gly Met Glu Asp  Ala Gly Pro Gly Ala  Asp Ile Ile 
    1520                 1525                 1530             


Gly Val  Asn Gly Gln Gly Pro  Asn Leu Glu Gly Lys  Ser Gln His 
    1535                 1540                 1545             


Val Asn  Gly Gly Val Met Asn  Gly Leu Glu Gln Ser  Glu Glu Val 
    1550                 1555                 1560             


Gly Gln  Gly Met Pro Leu Val  Ser Glu Gly Asp Arg  Gly Ser Pro 
    1565                 1570                 1575             


Phe Gln  Glu Glu Glu Gly Ser  Ala Leu Lys Thr Ser  Trp Ala Gly 
    1580                 1585                 1590             


Ala Pro  Val His Leu Gly Gln  Gly Gln Phe Leu Lys  Phe Thr Gln 
    1595                 1600                 1605             


Arg Glu  Gly Asp Arg Glu Ser  Trp Ser Ser Gly Glu  Asp 
    1610                 1615                 1620     


<210> 6147
<211> 125
<212> PRT
<213> Homo sapiens

<400> 6147
Met Glu Arg His Thr Ser His Pro Asn Arg Lys Val Pro Ala Lys Glu 
1               5                   10                  15      


Glu Ala Asn Ala Val Pro Leu Cys Arg Ala Lys Pro Ser Pro Ser Tyr 
            20                  25                  30          


Ile Asn Leu Gln Ala Ser Ser Pro Pro Ala Thr Phe Leu Asn Ile Gln 
        35                  40                  45              


Thr Thr Lys Leu Pro Ser Val Asp His Lys Pro Lys Glu Cys Leu Gly 
    50                  55                  60                  


Leu Leu Glu Cys Met Tyr Ala Asn Leu Gln Leu Gln Thr Gln Leu Ala 
65                  70                  75                  80  


Gln Gln Gln Met Ala Val Leu Glu His Leu Gln Ala Ser Val Thr Gln 
                85                  90                  95      


Leu Ala Pro Gly Arg Gly Ser Asn Asn Ser Ser Leu Pro Ala Leu Ser 
            100                 105                 110         


Pro Asn Pro Leu Leu Asn His Leu Pro Gln Phe Ser Lys 
        115                 120                 125 


<210> 6148
<211> 125
<212> PRT
<213> Homo sapiens

<400> 6148
Met Glu Arg His Thr Ser His Pro Asn Arg Lys Val Pro Ala Lys Glu 
1               5                   10                  15      


Glu Ala Asn Ala Val Pro Leu Cys Arg Ala Lys Pro Ser Pro Ser Tyr 
            20                  25                  30          


Ile Asn Leu Gln Ala Ser Ser Pro Pro Ala Thr Phe Leu Asn Ile Gln 
        35                  40                  45              


Thr Thr Lys Leu Pro Ser Val Asp His Lys Pro Lys Glu Cys Leu Gly 
    50                  55                  60                  


Leu Leu Glu Cys Met Tyr Ala Asn Leu Gln Leu Gln Thr Gln Leu Ala 
65                  70                  75                  80  


Gln Gln Gln Met Ala Val Leu Glu His Leu Gln Ala Ser Val Thr Gln 
                85                  90                  95      


Leu Ala Pro Gly Arg Gly Ser Asn Asn Ser Ser Leu Pro Ala Leu Ser 
            100                 105                 110         


Pro Asn Pro Leu Leu Asn His Leu Pro Gln Phe Ser Lys 
        115                 120                 125 


<210> 6149
<211> 125
<212> PRT
<213> Homo sapiens

<400> 6149
Met Glu Arg His Thr Ser His Pro Asn Arg Lys Val Pro Ala Lys Glu 
1               5                   10                  15      


Glu Ala Asn Ala Val Pro Leu Cys Arg Ala Lys Pro Ser Pro Ser Tyr 
            20                  25                  30          


Ile Asn Leu Gln Ala Ser Ser Pro Pro Ala Thr Phe Leu Asn Ile Gln 
        35                  40                  45              


Thr Thr Lys Leu Pro Ser Val Asp His Lys Pro Lys Glu Cys Leu Gly 
    50                  55                  60                  


Leu Leu Glu Cys Met Tyr Ala Asn Leu Gln Leu Gln Thr Gln Leu Ala 
65                  70                  75                  80  


Gln Gln Gln Met Ala Val Leu Glu His Leu Gln Ala Ser Val Thr Gln 
                85                  90                  95      


Leu Ala Pro Gly Arg Gly Ser Asn Asn Ser Ser Leu Pro Ala Leu Ser 
            100                 105                 110         


Pro Asn Pro Leu Leu Asn His Leu Pro Gln Phe Ser Lys 
        115                 120                 125 


<210> 6150
<211> 125
<212> PRT
<213> Homo sapiens

<400> 6150
Met Glu Arg His Thr Ser His Pro Asn Arg Lys Val Pro Ala Lys Glu 
1               5                   10                  15      


Glu Ala Asn Ala Val Pro Leu Cys Arg Ala Lys Pro Ser Pro Ser Tyr 
            20                  25                  30          


Ile Asn Leu Gln Ala Ser Ser Pro Pro Ala Thr Phe Leu Asn Ile Gln 
        35                  40                  45              


Thr Thr Lys Leu Pro Ser Val Asp His Lys Pro Lys Glu Cys Leu Gly 
    50                  55                  60                  


Leu Leu Glu Cys Met Tyr Ala Asn Leu Gln Leu Gln Thr Gln Leu Ala 
65                  70                  75                  80  


Gln Gln Gln Met Ala Val Leu Glu His Leu Gln Ala Ser Val Thr Gln 
                85                  90                  95      


Leu Ala Pro Gly Arg Gly Ser Asn Asn Ser Ser Leu Pro Ala Leu Ser 
            100                 105                 110         


Pro Asn Pro Leu Leu Asn His Leu Pro Gln Phe Ser Lys 
        115                 120                 125 


<210> 6151
<211> 125
<212> PRT
<213> Homo sapiens

<400> 6151
Met Glu Arg His Thr Ser His Pro Asn Arg Lys Val Pro Ala Lys Glu 
1               5                   10                  15      


Glu Ala Asn Ala Val Pro Leu Cys Arg Ala Lys Pro Ser Pro Ser Tyr 
            20                  25                  30          


Ile Asn Leu Gln Ala Ser Ser Pro Pro Ala Thr Phe Leu Asn Ile Gln 
        35                  40                  45              


Thr Thr Lys Leu Pro Ser Val Asp His Lys Pro Lys Glu Cys Leu Gly 
    50                  55                  60                  


Leu Leu Glu Cys Met Tyr Ala Asn Leu Gln Leu Gln Thr Gln Leu Ala 
65                  70                  75                  80  


Gln Gln Gln Met Ala Val Leu Glu His Leu Gln Ala Ser Val Thr Gln 
                85                  90                  95      


Leu Ala Pro Gly Arg Gly Ser Asn Asn Ser Ser Leu Pro Ala Leu Ser 
            100                 105                 110         


Pro Asn Pro Leu Leu Asn His Leu Pro Gln Phe Ser Lys 
        115                 120                 125 


<210> 6152
<211> 207
<212> PRT
<213> Homo sapiens

<400> 6152
Met Ala Glu Ala Ser Ser Ala Asn Leu Gly Ser Gly Cys Glu Glu Lys 
1               5                   10                  15      


Arg His Glu Gly Ser Ser Ser Glu Ser Val Pro Pro Gly Thr Thr Ile 
            20                  25                  30          


Ser Arg Val Lys Leu Leu Asp Thr Met Val Asp Thr Phe Leu Gln Lys 
        35                  40                  45              


Leu Val Ala Ala Gly Ser Ser Pro Leu Leu His Trp Asp Gly Ser Ala 
    50                  55                  60                  


Gly Pro Arg Leu Pro Ser Gly Gly Gln Ser Val Lys Gln Ala Phe Ser 
65                  70                  75                  80  


Trp Ala Ala Cys Arg Leu Pro Gln Gly Arg Lys Glu Glu Ile Ser Asp 
                85                  90                  95      


Ile Lys Glu Glu Gly Asn Leu Glu Ala Val Leu Asn Ala Leu Asp Lys 
            100                 105                 110         


Ile Val Glu Glu Gly Lys Val Arg Lys Glu Pro Ala Trp Arg Pro Ser 
        115                 120                 125             


Gly Ile Pro Glu Lys Asp Leu His Ser Val Met Ala Pro Tyr Phe Leu 
    130                 135                 140                 


Gln Gln Arg Asp Thr Leu Arg Arg His Val Gln Lys Gln Glu Ala Glu 
145                 150                 155                 160 


Asn Gln Gln Leu Ala Asp Ala Val Leu Ala Gly Arg Arg Gln Val Glu 
                165                 170                 175     


Glu Leu Gln Leu Gln Val Gln Ala Gln Gln Gln Ala Trp Gln Ala Leu 
            180                 185                 190         


His Arg Glu Gln Arg Glu Leu Val Ala Val Leu Arg Glu Pro Glu 
        195                 200                 205         


<210> 6153
<211> 205
<212> PRT
<213> Homo sapiens

<400> 6153
Met Ala Glu Ala Ser Ser Ala Asn Leu Gly Ser Gly Cys Glu Glu Lys 
1               5                   10                  15      


Arg His Glu Gly Ser Ser Ser Glu Ser Val Pro Pro Gly Thr Thr Ile 
            20                  25                  30          


Ser Arg Val Lys Leu Leu Asp Thr Met Val Asp Thr Phe Leu Gln Lys 
        35                  40                  45              


Leu Val Ala Ala Gly Ser Tyr Gln Arg Phe Thr Asp Cys Tyr Lys Cys 
    50                  55                  60                  


Phe Tyr Gln Leu Gln Pro Ala Met Thr Gln Gln Ile Tyr Asp Lys Phe 
65                  70                  75                  80  


Ile Ala Gln Leu Gln Thr Ser Ile Arg Glu Glu Ile Ser Asp Ile Lys 
                85                  90                  95      


Glu Glu Gly Asn Leu Glu Ala Val Leu Asn Ala Leu Asp Lys Ile Val 
            100                 105                 110         


Glu Glu Gly Lys Val Arg Lys Glu Pro Ala Trp Arg Pro Ser Gly Ile 
        115                 120                 125             


Pro Glu Lys Asp Leu His Ser Val Met Ala Pro Tyr Phe Leu Gln Gln 
    130                 135                 140                 


Arg Asp Thr Leu Arg Arg His Val Gln Lys Gln Glu Ala Glu Asn Gln 
145                 150                 155                 160 


Gln Leu Ala Asp Ala Val Leu Ala Gly Arg Arg Gln Val Glu Glu Leu 
                165                 170                 175     


Gln Leu Gln Val Gln Ala Gln Gln Gln Ala Trp Gln Ala Leu His Arg 
            180                 185                 190         


Glu Gln Arg Glu Leu Val Ala Val Leu Arg Glu Pro Glu 
        195                 200                 205 


<210> 6154
<211> 180
<212> PRT
<213> Homo sapiens

<400> 6154
Met Ala Glu Ala Ser Ser Ala Asn Leu Gly Ser Gly Cys Glu Glu Lys 
1               5                   10                  15      


Arg His Glu Gly Ser Ser Ser Glu Ser Val Pro Pro Gly Thr Thr Ile 
            20                  25                  30          


Ser Arg Val Lys Leu Leu Asp Thr Met Val Asp Thr Phe Leu Gln Lys 
        35                  40                  45              


Leu Val Ala Ala Gly Ser Tyr Gln Arg Phe Thr Asp Cys Tyr Lys Cys 
    50                  55                  60                  


Phe Tyr Gln Leu Gln Pro Ala Met Thr Gln Gln Ile Tyr Asp Lys Phe 
65                  70                  75                  80  


Ile Ala Gln Leu Gln Thr Ser Ile Arg Glu Glu Ile Ser Asp Ile Lys 
                85                  90                  95      


Glu Glu Gly Asn Leu Glu Ala Val Leu Asn Ala Leu Asp Lys Ile Val 
            100                 105                 110         


Glu Glu Gly Lys Val Arg Lys Glu Pro Ala Cys Asn Gly Thr Pro Cys 
        115                 120                 125             


Gly Ala Met Cys Arg Asn Arg Arg Pro Arg Thr Ser Ser Trp Gln Met 
    130                 135                 140                 


Pro Ser Trp Gln Gly Gly Gly Arg Trp Arg Ser Cys Ser Tyr Arg Ser 
145                 150                 155                 160 


Arg Pro Ser Ser Arg Pro Gly Arg Leu Tyr Thr Glu Asn Arg Gly Ser 
                165                 170                 175     


Trp Leu Leu Cys 
            180 


<210> 6155
<211> 750
<212> PRT
<213> Homo sapiens

<400> 6155
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala 
    130                 135                 140                 


Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr 
145                 150                 155                 160 


Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp 
                165                 170                 175     


Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys 
            180                 185                 190         


Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys Gln Val Ala Trp Ile 
        195                 200                 205             


Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu Leu Leu Pro Val Cys 
    210                 215                 220                 


Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala 
225                 230                 235                 240 


Glu Asp Asn Leu Leu Ala Leu Gly Leu Lys His Phe Glu Gly Thr Glu 
                245                 250                 255     


Phe Leu Asn Pro Leu Ile Ser Lys Tyr Leu Leu Thr Cys Lys Thr Ala 
            260                 265                 270         


Arg Gln Leu Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala Pro 
        275                 280                 285             


Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu 
    290                 295                 300                 


Gly Lys Cys Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro Ile 
305                 310                 315                 320 


Glu Arg Glu Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro 
                325                 330                 335     


Ser Ile Gln Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu Val 
            340                 345                 350         


Gly Asn Met Thr Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu Glu 
        355                 360                 365             


Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu Leu 
    370                 375                 380                 


Pro Lys Gly Val Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe Pro 
385                 390                 395                 400 


Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu Leu 
                405                 410                 415     


Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys Thr 
            420                 425                 430         


Pro Ala Gln Ser Thr His Ser Glu Ala Pro Pro Ser Lys Met Val Leu 
        435                 440                 445             


Arg Ile Pro His Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val Pro 
    450                 455                 460                 


Gly Val Pro Pro Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser Pro 
465                 470                 475                 480 


Ala Ala Leu Pro Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro Leu 
                485                 490                 495     


Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val Met 
            500                 505                 510         


Met Pro Ser Pro Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg Arg 
        515                 520                 525             


Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys Pro 
    530                 535                 540                 


Ala Pro Val Ile His Pro Ala Ser Val Ile Phe Thr Val Pro Ala Thr 
545                 550                 555                 560 


Thr Val Lys Ile Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln Pro 
                565                 570                 575     


Val Asn Ala Ala Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala Thr 
            580                 585                 590         


Leu Leu Val Asn Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro Leu 
        595                 600                 605             


Val Ala Ser Ser Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val Asn 
    610                 615                 620                 


Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys Ala His Met Asn Val Asp 
625                 630                 635                 640 


Ile Ala Cys Ala Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu Glu 
                645                 650                 655     


Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val Phe 
            660                 665                 670         


Pro Lys Val Glu His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln Cys 
        675                 680                 685             


Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val Lys 
    690                 695                 700                 


Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile Gln 
705                 710                 715                 720 


Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val Lys 
                725                 730                 735     


Met Glu Pro Glu Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
            740                 745                 750 


<210> 6156
<211> 888
<212> PRT
<213> Homo sapiens

<400> 6156
Met Ala Gly Val Gly Arg Ser Gly Gly Pro Trp Gly Arg Thr Arg Gly 
1               5                   10                  15      


Gly Arg Ser Gly Arg Leu Gly Val Ser Leu Gly Ala Leu Ser Ser Leu 
            20                  25                  30          


Pro Leu Glu Glu Leu Pro Arg Pro Leu Cys Cys Arg Arg Cys Arg Arg 
        35                  40                  45              


His Phe Gly Phe Ala Leu Arg Gly Glu Thr Ile Pro Val Ser Val Ala 
    50                  55                  60                  


Gly Ser Ala Ser Ser Gln Phe Ala Pro Leu Ala Leu His Leu Ser Leu 
65                  70                  75                  80  


Leu Leu Ser Arg Ile Ser Ala Ser Arg Leu Thr Arg Trp Pro Pro Pro 
                85                  90                  95      


Asp Lys Arg Glu Gly Ser Ala Val Asp Pro Gly Lys Arg Arg Ser Leu 
            100                 105                 110         


Ala Ala Thr Pro Ser Ser Ser Leu Pro Cys Thr Leu Ile Ala Leu Gly 
        115                 120                 125             


Leu Arg His Glu Lys Glu Ala Asn Glu Leu Met Glu Asp Leu Phe Glu 
    130                 135                 140                 


Thr Phe Gln Asp Glu Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro 
145                 150                 155                 160 


Glu Glu Glu Glu Arg Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro 
                165                 170                 175     


Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln 
            180                 185                 190         


His Gln Ile Ala Lys Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro 
        195                 200                 205             


Ser Ala Lys Gln Gln Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys 
    210                 215                 220                 


Glu Val His Gln Thr Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu 
225                 230                 235                 240 


Gln Gln Gln Met Gln Gln His Val Gln Leu Leu Thr Gln Ile His Leu 
                245                 250                 255     


Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg 
            260                 265                 270         


Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu 
        275                 280                 285             


His His Gln Tyr Asn Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn 
    290                 295                 300                 


Leu Met Gly Ala Met Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser 
305                 310                 315                 320 


Ile Asp Cys Ser Pro His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe 
                325                 330                 335     


Pro Cys Leu Pro Lys Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val 
            340                 345                 350         


Phe Met Tyr Pro Glu Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn 
        355                 360                 365             


Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala Glu Asp Asn Leu Leu Ala 
    370                 375                 380                 


Leu Gly Leu Lys His Phe Glu Gly Thr Glu Phe Leu Asn Pro Leu Ile 
385                 390                 395                 400 


Ser Lys Tyr Leu Leu Thr Cys Lys Thr Ala Arg Gln Leu Thr Val Arg 
                405                 410                 415     


Ile Lys Asn Leu Asn Met Asn Arg Ala Pro Asp Asn Ile Ile Lys Phe 
            420                 425                 430         


Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu Gly Lys Cys Cys Glu Glu 
        435                 440                 445             


Ile Gln Pro His Gln Trp Lys Pro Pro Ile Glu Arg Glu Glu His Arg 
    450                 455                 460                 


Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro Ser Ile Gln Glu Glu Leu 
465                 470                 475                 480 


Arg His Met Ala Asp Gly Ala Arg Glu Val Gly Asn Met Thr Gly Thr 
                485                 490                 495     


Thr Glu Ile Asn Ser Asp Gln Gly Leu Glu Lys Asp Asn Ser Glu Leu 
            500                 505                 510         


Gly Ser Glu Thr Arg Tyr Pro Leu Leu Leu Pro Lys Gly Val Val Leu 
        515                 520                 525             


Lys Leu Lys Pro Val Ala Asp Arg Phe Pro Lys Lys Ala Trp Arg Gln 
    530                 535                 540                 


Lys Arg Ser Ser Val Leu Lys Pro Leu Leu Ile Gln Pro Ser Pro Ser 
545                 550                 555                 560 


Leu Gln Pro Ser Phe Asn Pro Gly Lys Thr Pro Ala Gln Ser Thr His 
                565                 570                 575     


Ser Glu Ala Pro Pro Ser Lys Met Val Leu Arg Ile Pro His Pro Ile 
            580                 585                 590         


Gln Pro Ala Thr Val Leu Gln Thr Val Pro Gly Val Pro Pro Leu Gly 
        595                 600                 605             


Val Ser Gly Gly Glu Ser Phe Glu Ser Pro Ala Ala Leu Pro Ala Met 
    610                 615                 620                 


Pro Pro Glu Ala Arg Thr Ser Phe Pro Leu Ser Glu Ser Gln Thr Leu 
625                 630                 635                 640 


Leu Ser Ser Ala Pro Val Pro Lys Val Met Met Pro Ser Pro Ala Ser 
                645                 650                 655     


Ser Met Phe Arg Lys Pro Tyr Val Arg Arg Arg Pro Ser Lys Arg Arg 
            660                 665                 670         


Gly Ala Arg Ala Phe Arg Cys Ile Lys Pro Ala Pro Val Ile His Pro 
        675                 680                 685             


Ala Ser Val Ile Phe Thr Val Pro Ala Thr Thr Val Lys Ile Val Ser 
    690                 695                 700                 


Leu Gly Gly Gly Cys Asn Met Ile Gln Pro Val Asn Ala Ala Val Ala 
705                 710                 715                 720 


Gln Ser Pro Gln Thr Ile Pro Ile Ala Thr Leu Leu Val Asn Pro Thr 
                725                 730                 735     


Ser Phe Pro Cys Pro Leu Asn Gln Pro Leu Val Ala Ser Ser Val Ser 
            740                 745                 750         


Pro Leu Ile Val Ser Gly Asn Ser Val Asn Leu Pro Ile Pro Ser Thr 
        755                 760                 765             


Pro Glu Asp Lys Ala His Met Asn Val Asp Ile Ala Cys Ala Val Ala 
    770                 775                 780                 


Asp Gly Glu Asn Ala Phe Gln Gly Leu Glu Pro Lys Leu Glu Pro Gln 
785                 790                 795                 800 


Glu Leu Ser Pro Leu Ser Ala Thr Val Phe Pro Lys Val Glu His Ser 
                805                 810                 815     


Pro Gly Pro Pro Pro Val Asp Lys Gln Cys Gln Glu Gly Leu Ser Glu 
            820                 825                 830         


Asn Ser Ala Tyr Arg Trp Thr Val Val Lys Thr Glu Glu Gly Arg Gln 
        835                 840                 845             


Ala Leu Glu Pro Leu Pro Gln Gly Ile Gln Glu Ser Leu Asn Asn Ser 
    850                 855                 860                 


Ser Pro Gly Asp Leu Glu Glu Val Val Lys Met Glu Pro Glu Asp Ala 
865                 870                 875                 880 


Thr Glu Glu Ile Ser Gly Phe Leu 
                885             


<210> 6157
<211> 868
<212> PRT
<213> Homo sapiens

<400> 6157
Met Ala Gly Val Gly Arg Ser Gly Gly Pro Trp Gly Arg Thr Arg Gly 
1               5                   10                  15      


Gly Arg Ser Gly Arg Leu Gly Val Ser Leu Gly Ala Leu Ser Ser Leu 
            20                  25                  30          


Pro Leu Glu Glu Leu Pro Arg Pro Leu Cys Cys Arg Arg Cys Arg Arg 
        35                  40                  45              


His Phe Gly Phe Ala Leu Arg Gly Glu Thr Ile Pro Val Ser Val Ala 
    50                  55                  60                  


Gly Ser Ala Ser Ser Gln Phe Ala Pro Leu Ala Leu His Leu Ser Leu 
65                  70                  75                  80  


Leu Leu Ser Arg Ile Ser Ala Ser Arg Leu Thr Arg Trp Pro Pro Pro 
                85                  90                  95      


Asp Lys Arg Glu Gly Ser Ala Val Asp Pro Gly Lys Arg Arg Ser Leu 
            100                 105                 110         


Ala Ala Thr Pro Ser Ser Ser Leu Pro Cys Thr Leu Ile Ala Leu Gly 
        115                 120                 125             


Leu Arg His Glu Lys Glu Ala Asn Glu Leu Met Glu Asp Leu Phe Glu 
    130                 135                 140                 


Thr Phe Gln Asp Glu Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro 
145                 150                 155                 160 


Glu Glu Glu Glu Arg Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro 
                165                 170                 175     


Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln 
            180                 185                 190         


His Gln Ile Ala Lys Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro 
        195                 200                 205             


Ser Ala Lys Gln Gln Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys 
    210                 215                 220                 


Glu Val His Gln Thr Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu 
225                 230                 235                 240 


Gln Gln Gln Met Gln Gln His Val Gln Leu Leu Thr Gln Ile His Leu 
                245                 250                 255     


Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg 
            260                 265                 270         


Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu 
        275                 280                 285             


His His Gln Tyr Asn Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn 
    290                 295                 300                 


Leu Met Gly Ala Met Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser 
305                 310                 315                 320 


Ile Asp Cys Ser Pro His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe 
                325                 330                 335     


Pro Cys Leu Pro Lys Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val 
            340                 345                 350         


Phe Met Tyr Pro Glu Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn 
        355                 360                 365             


Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala Glu Asp Asn Lys Tyr Leu 
    370                 375                 380                 


Leu Thr Cys Lys Thr Ala Arg Gln Leu Thr Val Arg Ile Lys Asn Leu 
385                 390                 395                 400 


Asn Met Asn Arg Ala Pro Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr 
                405                 410                 415     


Lys Gln Leu Pro Val Leu Gly Lys Cys Cys Glu Glu Ile Gln Pro His 
            420                 425                 430         


Gln Trp Lys Pro Pro Ile Glu Arg Glu Glu His Arg Leu Pro Phe Trp 
        435                 440                 445             


Leu Lys Ala Ser Leu Pro Ser Ile Gln Glu Glu Leu Arg His Met Ala 
    450                 455                 460                 


Asp Gly Ala Arg Glu Val Gly Asn Met Thr Gly Thr Thr Glu Ile Asn 
465                 470                 475                 480 


Ser Asp Gln Gly Leu Glu Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr 
                485                 490                 495     


Arg Tyr Pro Leu Leu Leu Pro Lys Gly Val Val Leu Lys Leu Lys Pro 
            500                 505                 510         


Val Ala Asp Arg Phe Pro Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser 
        515                 520                 525             


Val Leu Lys Pro Leu Leu Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser 
    530                 535                 540                 


Phe Asn Pro Gly Lys Thr Pro Ala Gln Ser Thr His Ser Glu Ala Pro 
545                 550                 555                 560 


Pro Ser Lys Met Val Leu Arg Ile Pro His Pro Ile Gln Pro Ala Thr 
                565                 570                 575     


Val Leu Gln Thr Val Pro Gly Val Pro Pro Leu Gly Val Ser Gly Gly 
            580                 585                 590         


Glu Ser Phe Glu Ser Pro Ala Ala Leu Pro Ala Met Pro Pro Glu Ala 
        595                 600                 605             


Arg Thr Ser Phe Pro Leu Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala 
    610                 615                 620                 


Pro Val Pro Lys Val Met Met Pro Ser Pro Ala Ser Ser Met Phe Arg 
625                 630                 635                 640 


Lys Pro Tyr Val Arg Arg Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala 
                645                 650                 655     


Phe Arg Cys Ile Lys Pro Ala Pro Val Ile His Pro Ala Ser Val Ile 
            660                 665                 670         


Phe Thr Val Pro Ala Thr Thr Val Lys Ile Val Ser Leu Gly Gly Gly 
        675                 680                 685             


Cys Asn Met Ile Gln Pro Val Asn Ala Ala Val Ala Gln Ser Pro Gln 
    690                 695                 700                 


Thr Ile Pro Ile Ala Thr Leu Leu Val Asn Pro Thr Ser Phe Pro Cys 
705                 710                 715                 720 


Pro Leu Asn Gln Pro Leu Val Ala Ser Ser Val Ser Pro Leu Ile Val 
                725                 730                 735     


Ser Gly Asn Ser Val Asn Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys 
            740                 745                 750         


Ala His Met Asn Val Asp Ile Ala Cys Ala Val Ala Asp Gly Glu Asn 
        755                 760                 765             


Ala Phe Gln Gly Leu Glu Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro 
    770                 775                 780                 


Leu Ser Ala Thr Val Phe Pro Lys Val Glu His Ser Pro Gly Pro Pro 
785                 790                 795                 800 


Pro Val Asp Lys Gln Cys Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr 
                805                 810                 815     


Arg Trp Thr Val Val Lys Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro 
            820                 825                 830         


Leu Pro Gln Gly Ile Gln Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp 
        835                 840                 845             


Leu Glu Glu Val Val Lys Met Glu Pro Glu Asp Ala Thr Glu Glu Ile 
    850                 855                 860                 


Ser Gly Phe Leu 
865             


<210> 6158
<211> 524
<212> PRT
<213> Homo sapiens

<400> 6158
Met Ala Gly Gly Ala Arg Glu Val Leu Thr Leu Gln Leu Gly His Phe 
1               5                   10                  15      


Ala Gly Phe Val Gly Ala His Trp Trp Asn Gln Gln Asp Ala Ala Leu 
            20                  25                  30          


Gly Arg Ala Thr Asp Ser Lys Glu Pro Pro Gly Glu Leu Cys Pro Asp 
        35                  40                  45              


Val Leu Tyr Arg Thr Gly Arg Thr Leu His Gly Gln Glu Thr Tyr Thr 
    50                  55                  60                  


Pro Arg Leu Ile Leu Met Asp Leu Lys Gly Ser Leu Ser Ser Leu Lys 
65                  70                  75                  80  


Glu Glu Gly Gly Leu Tyr Arg Asp Lys Gln Leu Asp Ala Ala Ile Ala 
                85                  90                  95      


Trp Gln Gly Lys Leu Thr Thr His Lys Gly Ser Ser Pro Leu Pro Thr 
            100                 105                 110         


Ala Thr Thr Pro Lys Pro Leu Ile Pro Thr Glu Ala Ser Ile Arg Val 
        115                 120                 125             


Trp Ser Asp Phe Leu Arg Val His Leu His Pro Arg Ser Ile Cys Met 
    130                 135                 140                 


Ile Gln Lys Tyr Asn His Asp Gly Glu Ala Gly Arg Leu Glu Ala Phe 
145                 150                 155                 160 


Gly Gln Gly Glu Ser Val Leu Lys Glu Pro Lys Tyr Gln Glu Glu Leu 
                165                 170                 175     


Glu Asp Arg Leu His Phe Tyr Val Glu Glu Cys Asp Tyr Leu Gln Gly 
            180                 185                 190         


Phe Gln Ile Leu Cys Asp Leu His Asp Gly Phe Ser Gly Val Gly Ala 
        195                 200                 205             


Lys Ala Ala Glu Leu Leu Gln Asp Glu Tyr Ser Gly Arg Gly Ile Ile 
    210                 215                 220                 


Thr Trp Gly Leu Leu Pro Gly Pro Tyr His Arg Gly Glu Ala Gln Arg 
225                 230                 235                 240 


Asn Ile Tyr Arg Leu Leu Asn Thr Ala Phe Gly Leu Val His Leu Thr 
                245                 250                 255     


Ala His Ser Ser Leu Val Cys Pro Leu Ser Leu Gly Gly Ser Leu Gly 
            260                 265                 270         


Leu Arg Pro Glu Pro Pro Val Ser Phe Pro Tyr Leu His Tyr Asp Ala 
        275                 280                 285             


Thr Leu Pro Phe His Cys Ser Ala Ile Leu Ala Thr Ala Leu Asp Thr 
    290                 295                 300                 


Val Thr Val Pro Tyr Arg Leu Cys Ser Ser Pro Val Ser Met Val His 
305                 310                 315                 320 


Leu Ala Asp Met Leu Ser Phe Cys Gly Lys Lys Val Val Thr Ala Gly 
                325                 330                 335     


Ala Ile Ile Pro Phe Pro Leu Ala Pro Gly Gln Ser Leu Pro Asp Ser 
            340                 345                 350         


Leu Met Gln Phe Gly Gly Ala Thr Pro Trp Thr Pro Leu Ser Ala Cys 
        355                 360                 365             


Gly Glu Pro Ser Gly Thr Arg Cys Phe Ala Gln Ser Val Val Leu Arg 
    370                 375                 380                 


Gly Ile Asp Arg Ala Cys His Thr Ser Gln Leu Thr Pro Gly Thr Pro 
385                 390                 395                 400 


Pro Pro Ser Ala Leu His Ala Cys Thr Thr Gly Glu Glu Ile Leu Ala 
                405                 410                 415     


Gln Tyr Leu Gln Gln Gln Gln Pro Gly Val Met Ser Ser Ser His Leu 
            420                 425                 430         


Leu Leu Thr Pro Cys Arg Val Ala Pro Pro Tyr Pro His Leu Phe Ser 
        435                 440                 445             


Ser Cys Ser Pro Pro Ala Val Glu Ser Ile Pro Val Phe Gly Ala Leu 
    450                 455                 460                 


Cys Ser Ser Ser Ser Leu His Gln Thr Leu Glu Ala Leu Ala Arg Asp 
465                 470                 475                 480 


Leu Thr Lys Leu Asp Leu Arg Arg Trp Ala Ser Phe Met Asp Ala Gly 
                485                 490                 495     


Val Glu His Asp Asp Val Ala Glu Leu Leu Gln Glu Leu Gln Ser Leu 
            500                 505                 510         


Ala Gln Cys Tyr Gln Gly Gly Asp Ser Leu Val Asp 
        515                 520                 


<210> 6159
<211> 492
<212> PRT
<213> Homo sapiens

<400> 6159
Met Pro Pro Thr Cys Ser Pro Gly Leu Arg Arg Gln Asp Trp Ala Pro 
1               5                   10                  15      


Gly Arg Cys Ala Gly Leu His Leu Pro Pro Arg Ala Pro Ser Ser Pro 
            20                  25                  30          


Ala Leu Gln Ala Leu Ala Gly Gln Ala Gly Val Arg Ser Ser Trp Ser 
        35                  40                  45              


Phe Ala Gly Val Pro Gly Ala Gln Arg Leu Trp Met Ala Glu Ala Gln 
    50                  55                  60                  


Ser Gly Thr Gly Gln Leu Gln Glu Gln Lys Lys Gly Leu Leu Ile Ala 
65                  70                  75                  80  


Val Ser Val Ser Val Asp Lys Ile Ile Ser His Phe Gly Ala Ala Arg 
                85                  90                  95      


Asn Leu Val Gln Lys Ala Gln Leu Gly Asp Ser Arg Leu Ser Pro Asp 
            100                 105                 110         


Val Gly His Leu Val Leu Thr Thr Leu Cys Pro Ala Leu His Ala Leu 
        115                 120                 125             


Val Ala Asp Gly Leu Lys Pro Phe Arg Lys Asp Leu Ile Thr Gly Gln 
    130                 135                 140                 


Arg Arg Ser Ser Pro Trp Ser Val Val Glu Ala Ser Val Lys Pro Gly 
145                 150                 155                 160 


Ser Ser Thr Arg Ser Leu Gly Thr Leu Tyr Ser Gln Val Ser Arg Leu 
                165                 170                 175     


Ala Pro Leu Ser Ser Ser Arg Ser Arg Phe His Ala Phe Ile Leu Gly 
            180                 185                 190         


Leu Leu Asn Thr Lys Gln Leu Glu Leu Trp Phe Ser Ser Leu Gln Glu 
        195                 200                 205             


Asp Ala Gly Leu Leu Ser Leu Leu Tyr Leu Pro Thr Gly Phe Phe Ser 
    210                 215                 220                 


Leu Ala Arg Gly Gly Cys Pro Ser Leu Ser Thr Glu Leu Leu Leu Leu 
225                 230                 235                 240 


Leu Gln Pro Leu Ser Val Leu Thr Phe His Leu Asp Leu Leu Phe Glu 
                245                 250                 255     


His His His His Leu Pro Leu Gly Pro Pro Gln Ala Pro Ala Pro Pro 
            260                 265                 270         


Gly Pro Pro Pro Ala Leu Gln Gln Thr Met Gln Ala Met Leu His Phe 
        275                 280                 285             


Gly Gly Arg Leu Ala Gln Ser Leu Arg Gly Thr Ser Lys Glu Ala Ala 
    290                 295                 300                 


Ser Asp Pro Ser Asp Ser Pro Asn Leu Pro Thr Pro Gly Ser Trp Trp 
305                 310                 315                 320 


Glu Gln Leu Thr Gln Ala Ser Arg Val Tyr Ala Ser Gly Gly Thr Glu 
                325                 330                 335     


Gly Phe Pro Leu Ser Arg Trp Ala Pro Gly Arg His Gly Thr Ala Ala 
            340                 345                 350         


Glu Glu Gly Ala Gln Glu Arg Pro Leu Pro Thr Asp Glu Met Ala Pro 
        355                 360                 365             


Gly Arg Gly Leu Trp Leu Gly Arg Leu Phe Gly Val Pro Gly Gly Pro 
    370                 375                 380                 


Ala Glu Asn Glu Asn Gly Ala Leu Lys Ser Arg Arg Pro Ser Ser Trp 
385                 390                 395                 400 


Leu Pro Pro Thr Val Ser Val Leu Ala Leu Val Lys Arg Gly Ala Pro 
                405                 410                 415     


Pro Glu Met Pro Ser Pro Gln Glu Leu Glu Ala Ser Ala Pro Arg Met 
            420                 425                 430         


Val Gln Thr His Arg Ala Val Arg Ala Leu Cys Asp His Thr Ala Ala 
        435                 440                 445             


Arg Pro Asp Gln Leu Ser Phe Arg Arg Gly Glu Val Leu Arg Val Ile 
    450                 455                 460                 


Thr Thr Val Asp Glu Asp Trp Leu Arg Cys Gly Arg Asp Gly Met Glu 
465                 470                 475                 480 


Gly Leu Val Pro Val Gly Tyr Thr Ser Leu Val Leu 
                485                 490         


<210> 6160
<211> 433
<212> PRT
<213> Homo sapiens

<400> 6160
Met Ala Glu Ala Gln Ser Gly Thr Gly Gln Leu Gln Glu Gln Lys Lys 
1               5                   10                  15      


Gly Leu Leu Ile Ala Val Ser Val Ser Val Asp Lys Ile Ile Ser His 
            20                  25                  30          


Phe Gly Ala Ala Arg Asn Leu Val Gln Lys Ala Gln Leu Gly Asp Ser 
        35                  40                  45              


Arg Leu Ser Pro Asp Val Gly His Leu Val Leu Thr Thr Leu Cys Pro 
    50                  55                  60                  


Ala Leu His Ala Leu Val Ala Asp Gly Leu Lys Pro Phe Arg Lys Asp 
65                  70                  75                  80  


Leu Ile Thr Gly Gln Arg Arg Ser Ser Pro Trp Ser Val Val Glu Ala 
                85                  90                  95      


Ser Val Lys Pro Gly Ser Ser Thr Arg Ser Leu Gly Thr Leu Tyr Ser 
            100                 105                 110         


Gln Val Ser Arg Leu Ala Pro Leu Ser Ser Ser Arg Ser Arg Phe His 
        115                 120                 125             


Ala Phe Ile Leu Gly Leu Leu Asn Thr Lys Gln Leu Glu Leu Trp Phe 
    130                 135                 140                 


Ser Ser Leu Gln Glu Asp Ala Gly Leu Leu Ser Leu Leu Tyr Leu Pro 
145                 150                 155                 160 


Thr Gly Phe Phe Ser Leu Ala Arg Gly Gly Cys Pro Ser Leu Ser Thr 
                165                 170                 175     


Glu Leu Leu Leu Leu Leu Gln Pro Leu Ser Val Leu Thr Phe His Leu 
            180                 185                 190         


Asp Leu Leu Phe Glu His His His His Leu Pro Leu Gly Pro Pro Gln 
        195                 200                 205             


Ala Pro Ala Pro Pro Gly Pro Pro Pro Ala Leu Gln Gln Thr Met Gln 
    210                 215                 220                 


Ala Met Leu His Phe Gly Gly Arg Leu Ala Gln Ser Leu Arg Gly Thr 
225                 230                 235                 240 


Ser Lys Glu Ala Ala Ser Asp Pro Ser Asp Ser Pro Asn Leu Pro Thr 
                245                 250                 255     


Pro Gly Ser Trp Trp Glu Gln Leu Thr Gln Ala Ser Arg Val Tyr Ala 
            260                 265                 270         


Ser Gly Gly Thr Glu Gly Phe Pro Leu Ser Arg Trp Ala Pro Gly Arg 
        275                 280                 285             


His Gly Thr Ala Ala Glu Glu Gly Ala Gln Glu Arg Pro Leu Pro Thr 
    290                 295                 300                 


Asp Glu Met Ala Pro Gly Arg Gly Leu Trp Leu Gly Arg Leu Phe Gly 
305                 310                 315                 320 


Val Pro Gly Gly Pro Ala Glu Asn Glu Asn Gly Ala Leu Lys Ser Arg 
                325                 330                 335     


Arg Pro Ser Ser Trp Leu Pro Pro Thr Val Ser Val Leu Ala Leu Val 
            340                 345                 350         


Lys Arg Gly Ala Pro Pro Glu Met Pro Ser Pro Gln Glu Leu Glu Ala 
        355                 360                 365             


Ser Ala Pro Arg Met Val Gln Thr His Arg Ala Val Arg Ala Leu Cys 
    370                 375                 380                 


Asp His Thr Ala Ala Arg Pro Asp Gln Leu Ser Phe Arg Arg Gly Glu 
385                 390                 395                 400 


Val Leu Arg Val Ile Thr Thr Val Asp Glu Asp Trp Leu Arg Cys Gly 
                405                 410                 415     


Arg Asp Gly Met Glu Gly Leu Val Pro Val Gly Tyr Thr Ser Leu Val 
            420                 425                 430         


Leu 
    


<210> 6161
<211> 902
<212> PRT
<213> Homo sapiens

<400> 6161
Met Leu Ser Pro Gln Arg Ala Leu Leu Cys Asn Leu Asn His Ile His 
1               5                   10                  15      


Leu Gln His Val Ser Leu Gly Leu His Leu Ser Arg Arg Pro Glu Leu 
            20                  25                  30          


Gln Glu Gly Pro Leu Ser Thr Pro Pro Pro Pro Gly Asp Thr Gly Gly 
        35                  40                  45              


Lys Glu Ser Arg Gly Pro Cys Ser Gly Thr Leu Val Asp Ala Asn Ser 
    50                  55                  60                  


Asn Ser Pro Ala Val Pro Cys Arg Cys Cys Gln Glu His Gly Pro Gly 
65                  70                  75                  80  


Leu Glu Asn Arg Gln Asp Pro Ser Gln Glu Glu Glu Gly Ala Ala Ser 
                85                  90                  95      


Pro Ser Asp Pro Gly Cys Ser Ser Ser Leu Ser Ser Cys Ser Asp Leu 
            100                 105                 110         


Ser Pro Asp Glu Ser Pro Val Ser Val Tyr Leu Arg Asp Leu Pro Gly 
        115                 120                 125             


Asp Glu Asp Ala His Pro Gln Pro Ser Ile Ile Pro Leu Glu Gln Gly 
    130                 135                 140                 


Ser Pro Leu Ala Ser Ala Gly Pro Gly Thr Cys Ser Pro Asp Ser Phe 
145                 150                 155                 160 


Cys Cys Ser Pro Asp Ser Cys Ser Gly Ala Ser Ser Ser Pro Asp Pro 
                165                 170                 175     


Gly Leu Asp Ser Asn Cys Asn Ala Leu Thr Thr Cys Gln Asp Val Pro 
            180                 185                 190         


Ser Pro Gly Leu Glu Glu Glu Asp Glu Arg Ala Glu Gln Asp Leu Pro 
        195                 200                 205             


Thr Ser Glu Leu Leu Glu Ala Asp Asp Gly Lys Ile Asp Ala Gly Lys 
    210                 215                 220                 


Thr Glu Pro Ser Trp Lys Ile Asn Pro Ile Trp Lys Ile Asp Thr Glu 
225                 230                 235                 240 


Lys Thr Lys Ala Glu Trp Lys Thr Thr Glu Asn Asn Asn Thr Gly Trp 
                245                 250                 255     


Lys Asn Asn Gly Asn Val Asn Ser Ser Trp Lys Ser Glu Pro Glu Lys 
            260                 265                 270         


Phe Asp Ser Gly Trp Lys Thr Asn Thr Arg Ile Thr Asp Ser Gly Ser 
        275                 280                 285             


Lys Thr Asp Ala Gly Lys Ile Asp Gly Gly Trp Arg Ser Asp Val Ser 
    290                 295                 300                 


Glu Glu Pro Val Pro His Arg Thr Ile Thr Ser Phe His Glu Leu Ala 
305                 310                 315                 320 


Gln Lys Arg Lys Arg Gly Pro Gly Leu Pro Leu Val Pro Gln Ala Lys 
                325                 330                 335     


Lys Asp Arg Ser Asp Trp Leu Ile Val Phe Ser Pro Asp Thr Glu Leu 
            340                 345                 350         


Pro Pro Ser Gly Ser Pro Gly Gly Ser Ser Ala Pro Pro Arg Glu Val 
        355                 360                 365             


Thr Thr Phe Lys Glu Leu Arg Ser Arg Ser Arg Ala Pro Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Arg Asp Pro Pro Val Gly Trp Ala Leu Val Pro Pro Arg 
385                 390                 395                 400 


Pro Pro Pro Pro Pro Val Pro Pro Arg Arg Lys Lys Asn Arg Pro Gly 
                405                 410                 415     


Leu Gln Pro Ile Ala Glu Gly Gln Ser Glu Glu Gly Arg Ala Val Ser 
            420                 425                 430         


Pro Ala Ala Gly Glu Glu Ala Pro Ala Ala Lys Glu Pro Gly Ala Gln 
        435                 440                 445             


Ala Gly Leu Glu Val Arg Ser Ser Trp Ser Phe Ala Gly Val Pro Gly 
    450                 455                 460                 


Ala Gln Arg Leu Trp Met Ala Glu Ala Gln Ser Gly Thr Gly Gln Leu 
465                 470                 475                 480 


Gln Glu Gln Lys Lys Gly Leu Leu Ile Ala Val Ser Val Ser Val Asp 
                485                 490                 495     


Lys Ile Ile Ser His Phe Gly Ala Ala Arg Asn Leu Val Gln Lys Ala 
            500                 505                 510         


Gln Leu Gly Asp Ser Arg Leu Ser Pro Asp Val Gly His Leu Val Leu 
        515                 520                 525             


Thr Thr Leu Cys Pro Ala Leu His Ala Leu Val Ala Asp Gly Leu Lys 
    530                 535                 540                 


Pro Phe Arg Lys Asp Leu Ile Thr Gly Gln Arg Arg Ser Ser Pro Trp 
545                 550                 555                 560 


Ser Val Val Glu Ala Ser Val Lys Pro Gly Ser Ser Thr Arg Ser Leu 
                565                 570                 575     


Gly Thr Leu Tyr Ser Gln Val Ser Arg Leu Ala Pro Leu Ser Ser Ser 
            580                 585                 590         


Arg Ser Arg Phe His Ala Phe Ile Leu Gly Leu Leu Asn Thr Lys Gln 
        595                 600                 605             


Leu Glu Leu Trp Phe Ser Ser Leu Gln Glu Asp Ala Gly Leu Leu Ser 
    610                 615                 620                 


Leu Leu Tyr Leu Pro Thr Gly Phe Phe Ser Leu Ala Arg Gly Gly Cys 
625                 630                 635                 640 


Pro Ser Leu Ser Thr Glu Leu Leu Leu Leu Leu Gln Pro Leu Ser Val 
                645                 650                 655     


Leu Thr Phe His Leu Asp Leu Leu Phe Glu His His His His Leu Pro 
            660                 665                 670         


Leu Gly Pro Pro Gln Ala Pro Ala Pro Pro Gly Pro Pro Pro Ala Leu 
        675                 680                 685             


Gln Gln Thr Met Gln Ala Met Leu His Phe Gly Gly Arg Leu Ala Gln 
    690                 695                 700                 


Ser Leu Arg Gly Thr Ser Lys Glu Ala Ala Ser Asp Pro Ser Asp Ser 
705                 710                 715                 720 


Pro Asn Leu Pro Thr Pro Gly Ser Trp Trp Glu Gln Leu Thr Gln Ala 
                725                 730                 735     


Ser Arg Val Tyr Ala Ser Gly Gly Thr Glu Gly Phe Pro Leu Ser Arg 
            740                 745                 750         


Trp Ala Pro Gly Arg His Gly Thr Ala Ala Glu Glu Gly Ala Gln Glu 
        755                 760                 765             


Arg Pro Leu Pro Thr Asp Glu Met Ala Pro Gly Arg Gly Leu Trp Leu 
    770                 775                 780                 


Gly Arg Leu Phe Gly Val Pro Gly Gly Pro Ala Glu Asn Glu Asn Gly 
785                 790                 795                 800 


Ala Leu Lys Ser Arg Arg Pro Ser Ser Trp Leu Pro Pro Thr Val Ser 
                805                 810                 815     


Val Leu Ala Leu Val Lys Arg Gly Ala Pro Pro Glu Met Pro Ser Pro 
            820                 825                 830         


Gln Glu Leu Glu Ala Ser Ala Pro Arg Met Val Gln Thr His Arg Ala 
        835                 840                 845             


Val Arg Ala Leu Cys Asp His Thr Ala Ala Arg Pro Asp Gln Leu Ser 
    850                 855                 860                 


Phe Arg Arg Gly Glu Val Leu Arg Val Ile Thr Thr Val Asp Glu Asp 
865                 870                 875                 880 


Trp Leu Arg Cys Gly Arg Asp Gly Met Glu Gly Leu Val Pro Val Gly 
                885                 890                 895     


Tyr Thr Ser Leu Val Leu 
            900         


<210> 6162
<211> 796
<212> PRT
<213> Homo sapiens

<400> 6162
Met Leu Ser Pro Gln Arg Ala Leu Leu Cys Asn Leu Asn His Ile His 
1               5                   10                  15      


Leu Gln His Val Ser Leu Gly Leu His Leu Ser Arg Arg Pro Glu Leu 
            20                  25                  30          


Gln Glu Gly Pro Leu Ser Thr Pro Pro Pro Pro Gly Asp Thr Gly Gly 
        35                  40                  45              


Lys Glu Ser Arg Gly Pro Cys Ser Gly Thr Leu Val Asp Ala Asn Ser 
    50                  55                  60                  


Asn Ser Pro Ala Val Pro Cys Arg Cys Cys Gln Glu His Gly Pro Gly 
65                  70                  75                  80  


Leu Glu Asn Arg Gln Asp Pro Ser Gln Glu Glu Glu Gly Ala Ala Ser 
                85                  90                  95      


Pro Ser Asp Pro Gly Cys Ser Ser Ser Leu Ser Ser Cys Ser Asp Leu 
            100                 105                 110         


Ser Pro Asp Glu Ser Pro Val Ser Val Tyr Leu Arg Asp Leu Pro Gly 
        115                 120                 125             


Asp Glu Asp Ala His Pro Gln Pro Ser Ile Ile Pro Leu Glu Gln Gly 
    130                 135                 140                 


Ser Pro Leu Ala Ser Ala Gly Pro Gly Thr Cys Ser Pro Asp Ser Phe 
145                 150                 155                 160 


Cys Cys Ser Pro Asp Ser Cys Ser Gly Ala Ser Ser Ser Pro Asp Pro 
                165                 170                 175     


Gly Leu Asp Ser Asn Cys Asn Ala Leu Thr Thr Cys Gln Asp Val Pro 
            180                 185                 190         


Ser Pro Gly Leu Glu Glu Glu Asp Glu Arg Ala Glu Gln Asp Leu Pro 
        195                 200                 205             


Thr Ser Glu Leu Leu Glu Ala Asp Asp Gly Lys Ile Asp Ala Gly Lys 
    210                 215                 220                 


Thr Glu Pro Ser Trp Lys Ile Asn Pro Ile Trp Lys Ile Asp Thr Glu 
225                 230                 235                 240 


Lys Thr Lys Ala Glu Trp Lys Thr Thr Glu Asn Asn Asn Thr Gly Trp 
                245                 250                 255     


Lys Asn Asn Gly Asn Val Asn Ser Ser Trp Lys Ser Glu Pro Glu Lys 
            260                 265                 270         


Phe Asp Ser Gly Trp Lys Thr Asn Thr Arg Ile Thr Asp Ser Gly Ser 
        275                 280                 285             


Lys Thr Asp Ala Gly Lys Ile Asp Gly Gly Trp Arg Ser Asp Val Ser 
    290                 295                 300                 


Glu Glu Pro Val Pro His Arg Thr Ile Thr Ser Phe His Glu Leu Ala 
305                 310                 315                 320 


Gln Lys Arg Lys Arg Gly Pro Gly Leu Pro Leu Val Pro Gln Ala Lys 
                325                 330                 335     


Lys Asp Arg Ser Asp Trp Leu Ile Val Phe Ser Pro Asp Thr Glu Leu 
            340                 345                 350         


Pro Pro Ser Gly Ser Pro Gly Gly Ser Ser Ala Pro Pro Arg Glu Val 
        355                 360                 365             


Thr Thr Phe Lys Glu Leu Arg Ser Arg Ser Arg Ala Pro Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Arg Asp Pro Pro Val Gly Trp Ala Leu Val Pro Pro Arg 
385                 390                 395                 400 


Pro Pro Pro Pro Pro Val Pro Pro Arg Arg Lys Lys Asn Arg Pro Gly 
                405                 410                 415     


Leu Gln Pro Ile Ala Glu Gly Gln Ser Glu Glu Gly Arg Ala Val Ser 
            420                 425                 430         


Pro Ala Ala Gly Glu Glu Ala Pro Ala Ala Lys Glu Pro Gly Ala Gln 
        435                 440                 445             


Ala Gly Leu Glu Val Arg Ser Ser Trp Ser Phe Ala Gly Val Pro Gly 
    450                 455                 460                 


Ala Gln Arg Leu Trp Met Ala Glu Ala Gln Ser Gly Thr Gly Gln Leu 
465                 470                 475                 480 


Gln Glu Gln Lys Lys Gly Leu Leu Ile Ala Val Ser Val Ser Val Asp 
                485                 490                 495     


Lys Ile Ile Ser His Phe Gly Ala Ala Arg Asn Leu Val Gln Lys Ala 
            500                 505                 510         


Gln Leu Gly Asp Ser Arg Leu Ser Pro Asp Val Gly His Leu Val Leu 
        515                 520                 525             


Thr Thr Leu Cys Pro Ala Leu His Ala Leu Val Ala Asp Gly Leu Lys 
    530                 535                 540                 


Pro Phe Arg Lys Asp Leu Ile Thr Gly Gln Arg Arg Ser Ser Pro Trp 
545                 550                 555                 560 


Ser Val Val Glu Ala Ser Val Lys Pro Gly Ser Ser Thr Arg Ser Leu 
                565                 570                 575     


Gly Thr Leu Tyr Ser Gln Val Ser Arg Leu Ala Pro Leu Ser Ser Ser 
            580                 585                 590         


Arg Ser Arg Phe His Ala Phe Ile Leu Gly Leu Leu Asn Thr Lys Gln 
        595                 600                 605             


Leu Glu Leu Trp Phe Ser Ser Leu Gln Glu Asp Ala Gly Ser Trp Trp 
    610                 615                 620                 


Glu Gln Leu Thr Gln Ala Ser Arg Val Tyr Ala Ser Gly Gly Thr Glu 
625                 630                 635                 640 


Gly Phe Pro Leu Ser Arg Trp Ala Pro Gly Arg His Gly Thr Ala Ala 
                645                 650                 655     


Glu Glu Gly Ala Gln Glu Arg Pro Leu Pro Thr Asp Glu Met Ala Pro 
            660                 665                 670         


Gly Arg Gly Leu Trp Leu Gly Arg Leu Phe Gly Val Pro Gly Gly Pro 
        675                 680                 685             


Ala Glu Asn Glu Asn Gly Ala Leu Lys Ser Arg Arg Pro Ser Ser Trp 
    690                 695                 700                 


Leu Pro Pro Thr Val Ser Val Leu Ala Leu Val Lys Arg Gly Ala Pro 
705                 710                 715                 720 


Pro Glu Met Pro Ser Pro Gln Glu Leu Glu Ala Ser Ala Pro Arg Met 
                725                 730                 735     


Val Gln Thr His Arg Ala Val Arg Ala Leu Cys Asp His Thr Ala Ala 
            740                 745                 750         


Arg Pro Asp Gln Leu Ser Phe Arg Arg Gly Glu Val Leu Arg Val Ile 
        755                 760                 765             


Thr Thr Val Asp Glu Asp Trp Leu Arg Cys Gly Arg Asp Gly Met Glu 
    770                 775                 780                 


Gly Leu Val Pro Val Gly Tyr Thr Ser Leu Val Leu 
785                 790                 795     


<210> 6163
<211> 170
<212> PRT
<213> Homo sapiens

<400> 6163
Met Ala Ser Val Ser Ser Ala Thr Phe Ser Gly His Gly Ala Arg Ser 
1               5                   10                  15      


Leu Leu Gln Phe Leu Arg Leu Val Gly Gln Leu Lys Arg Val Pro Arg 
            20                  25                  30          


Thr Gly Trp Val Tyr Arg Asn Val Gln Arg Pro Glu Ser Val Ser Asp 
        35                  40                  45              


His Met Tyr Arg Met Ala Val Met Ala Met Val Ile Lys Asp Asp Arg 
    50                  55                  60                  


Leu Asn Lys Asp Arg Glu Ala Met Lys Gln Ile Thr Gln Leu Leu Pro 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Glu Leu Tyr Glu Leu Trp Glu Glu Tyr Glu Thr 
                85                  90                  95      


Gln Ser Ser Ala Glu Ala Lys Phe Val Lys Gln Leu Asp Gln Cys Glu 
            100                 105                 110         


Met Ile Leu Gln Ala Ser Glu Tyr Glu Asp Leu Glu His Lys Pro Gly 
        115                 120                 125             


Arg Leu Gln Asp Phe Tyr Asp Ser Thr Ala Gly Lys Phe Asn His Pro 
    130                 135                 140                 


Glu Ile Val Gln Leu Val Ser Glu Leu Glu Ala Glu Arg Ser Thr Asn 
145                 150                 155                 160 


Ile Ala Ala Ala Ala Ser Glu Pro His Ser 
                165                 170 


<210> 6164
<211> 131
<212> PRT
<213> Homo sapiens

<400> 6164
Met Glu Ala Gln Ala Gln Gly Leu Leu Glu Thr Glu Pro Leu Gln Gly 
1               5                   10                  15      


Thr Asp Glu Asp Ala Val Ala Ser Ala Asp Phe Ser Ser Met Leu Ser 
            20                  25                  30          


Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln Leu Glu Asp 
        35                  40                  45              


Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu Arg His Leu 
    50                  55                  60                  


Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn Glu Leu Lys 
65                  70                  75                  80  


Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr Thr Ala Tyr 
                85                  90                  95      


Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys Ala Thr Ala 
            100                 105                 110         


Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe Gly Asp Met 
        115                 120                 125             


Arg Arg Lys 
    130     


<210> 6165
<211> 144
<212> PRT
<213> Homo sapiens

<400> 6165
Met Glu Ala Gln Ala Gln Gly Leu Leu Glu Thr Glu Pro Leu Gln Gly 
1               5                   10                  15      


Thr Asp Glu Asp Ala Val Ala Ser Ala Asp Phe Ser Ser Met Leu Ser 
            20                  25                  30          


Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln Leu Glu Asp 
        35                  40                  45              


Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu Arg His Leu 
    50                  55                  60                  


Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn Glu Leu Lys 
65                  70                  75                  80  


Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr Thr Ala Tyr 
                85                  90                  95      


Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys Ala Thr Ala 
            100                 105                 110         


Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe Gly Asp Met 
        115                 120                 125             


Ser Tyr Ser Ile Arg His Ser Ile Ser Met Pro Ala Met Arg Arg Lys 
    130                 135                 140                 


<210> 6166
<211> 315
<212> PRT
<213> Homo sapiens

<400> 6166
Met Ala Ser Cys Pro Asp Ser Asp Asn Ser Trp Val Leu Ala Gly Ser 
1               5                   10                  15      


Glu Ser Leu Pro Val Glu Thr Leu Gly Pro Ala Ser Arg Met Asp Pro 
            20                  25                  30          


Glu Ser Glu Arg Ala Leu Gln Ala Pro His Ser Pro Ser Lys Thr Asp 
        35                  40                  45              


Gly Lys Glu Leu Ala Gly Thr Met Asp Gly Glu Gly Thr Leu Phe Gln 
    50                  55                  60                  


Thr Glu Ser Pro Gln Ser Gly Ser Ile Leu Thr Glu Glu Thr Glu Val 
65                  70                  75                  80  


Lys Gly Thr Leu Glu Gly Asp Val Cys Gly Val Glu Pro Pro Gly Pro 
                85                  90                  95      


Gly Asp Thr Val Val Gln Gly Asp Leu Gln Glu Thr Thr Val Val Thr 
            100                 105                 110         


Gly Leu Gly Pro Asp Thr Gln Asp Leu Glu Gly Gln Ser Pro Pro Gln 
        115                 120                 125             


Ser Leu Pro Ser Thr Pro Lys Ala Ala Trp Ile Arg Glu Glu Gly Arg 
    130                 135                 140                 


Cys Ser Ser Ser Asp Asp Asp Thr Asp Val Asp Met Glu Gly Leu Arg 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Glu Ala Gly Pro Pro Gln Pro Met Val Pro Leu 
                165                 170                 175     


Ala Val Glu Asn Gln Ala Gly Gly Gly Leu Ser Glu Ser Glu Thr Gly 
            180                 185                 190         


Pro Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu Val Leu 
        195                 200                 205             


Glu Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu Gln Ala 
    210                 215                 220                 


Pro Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly Leu Leu 
225                 230                 235                 240 


Leu Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu Gln Ala 
                245                 250                 255     


Gln Leu Gln Val Gly Thr Gly Arg Arg Gly Trp Ala Arg Val Thr His 
            260                 265                 270         


Leu Gly Gln Ala Ser Val Leu Ala Ser Ser Pro Lys Arg Asn Val Ser 
        275                 280                 285             


Tyr Leu Pro Thr His Pro Asp Pro Pro Leu Ser His Tyr Ser Gln Gly 
    290                 295                 300                 


Val Phe Pro Val Leu Gly Ser His Pro Leu Cys 
305                 310                 315 


<210> 6167
<211> 731
<212> PRT
<213> Homo sapiens

<400> 6167
Met Ala Ser Cys Pro Asp Ser Asp Asn Ser Trp Val Leu Ala Gly Ser 
1               5                   10                  15      


Glu Ser Leu Pro Val Glu Thr Leu Gly Pro Ala Ser Arg Met Asp Pro 
            20                  25                  30          


Glu Ser Glu Arg Ala Leu Gln Ala Pro His Ser Pro Ser Lys Thr Asp 
        35                  40                  45              


Gly Lys Glu Leu Ala Gly Thr Met Asp Gly Glu Gly Thr Leu Phe Gln 
    50                  55                  60                  


Thr Glu Ser Pro Gln Ser Gly Ser Ile Leu Thr Glu Glu Thr Glu Val 
65                  70                  75                  80  


Lys Gly Thr Leu Glu Gly Asp Val Cys Gly Val Glu Pro Pro Gly Pro 
                85                  90                  95      


Gly Asp Thr Val Val Gln Gly Asp Leu Gln Glu Thr Thr Val Val Thr 
            100                 105                 110         


Gly Leu Gly Pro Asp Thr Gln Asp Leu Glu Gly Gln Ser Pro Pro Gln 
        115                 120                 125             


Ser Leu Pro Ser Thr Pro Lys Ala Ala Trp Ile Arg Glu Glu Gly Arg 
    130                 135                 140                 


Cys Ser Ser Ser Asp Asp Asp Thr Asp Val Asp Met Glu Gly Leu Arg 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Glu Ala Gly Pro Pro Gln Pro Met Val Pro Leu 
                165                 170                 175     


Ala Val Glu Asn Gln Ala Gly Gly Glu Gly Ala Gly Gly Glu Leu Gly 
            180                 185                 190         


Ile Ser Leu Asn Met Cys Leu Leu Gly Ala Leu Val Leu Leu Gly Leu 
        195                 200                 205             


Gly Val Leu Leu Phe Ser Gly Gly Leu Ser Glu Ser Glu Thr Gly Pro 
    210                 215                 220                 


Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu Val Leu Glu 
225                 230                 235                 240 


Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu Gln Ala Pro 
                245                 250                 255     


Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly Leu Leu Leu 
            260                 265                 270         


Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu Gln Ala Gln 
        275                 280                 285             


Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu Met His Gln Pro Lys 
    290                 295                 300                 


Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly Ala Leu Gln Gln Gly 
305                 310                 315                 320 


Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu Gln Gln Leu Arg Ala 
                325                 330                 335     


Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg Gly Pro Asp Gly Val 
            340                 345                 350         


Cys Leu Ser Gly Gly Arg Gly Pro Gln Gly Asp Lys Ala Ile Arg Glu 
        355                 360                 365             


Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser Phe Leu Lys Gln Lys 
    370                 375                 380                 


Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg Gln Glu Leu Glu Arg 
385                 390                 395                 400 


Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp Leu Glu Arg Ser Leu 
                405                 410                 415     


Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala Gly Leu Ala Glu Leu 
            420                 425                 430         


Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu Glu Asn Trp Gly Gln 
        435                 440                 445             


Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala Trp His Gln Lys Ser 
    450                 455                 460                 


His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys Glu Lys Trp Trp Asp 
465                 470                 475                 480 


Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys His Lys Lys Glu Glu 
                485                 490                 495     


Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly Gln Glu Asp Arg Glu 
            500                 505                 510         


Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg Val Glu Glu Ser Gly 
        515                 520                 525             


Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys Glu Pro Pro Arg Lys 
    530                 535                 540                 


Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln Lys Gln Pro Arg Trp 
545                 550                 555                 560 


Arg Glu Gly Thr Lys Asp Ser His Asp Pro Leu Pro Ser Trp Ala Glu 
                565                 570                 575     


Leu Leu Arg Pro Lys Tyr Arg Ala Pro Gln Gly Cys Ser Gly Val Asp 
            580                 585                 590         


Glu Cys Ala Arg Gln Glu Gly Leu Thr Phe Phe Gly Thr Glu Leu Ala 
        595                 600                 605             


Pro Val Arg Gln Gln Glu Leu Ala Ser Leu Leu Arg Thr Tyr Leu Ala 
    610                 615                 620                 


Arg Leu Pro Trp Ala Gly Gln Leu Thr Lys Glu Leu Pro Leu Ser Pro 
625                 630                 635                 640 


Ala Phe Phe Gly Glu Asp Gly Ile Phe Arg His Asp Arg Leu Arg Phe 
                645                 650                 655     


Arg Asp Phe Val Asp Ala Leu Glu Asp Ser Leu Glu Glu Val Ala Val 
            660                 665                 670         


Gln Gln Thr Gly Asp Asp Asp Glu Val Asp Asp Phe Glu Asp Phe Ile 
        675                 680                 685             


Phe Ser His Phe Phe Gly Asp Lys Ala Leu Lys Lys Arg Ser Gly Lys 
    690                 695                 700                 


Lys Asp Lys His Ser Gln Ser Pro Arg Ala Ala Gly Pro Arg Glu Gly 
705                 710                 715                 720 


His Ser His Ser His His His His His Arg Gly 
                725                 730     


<210> 6168
<211> 702
<212> PRT
<213> Homo sapiens

<400> 6168
Met Asp Pro Glu Ser Glu Arg Ala Leu Gln Ala Pro His Ser Pro Ser 
1               5                   10                  15      


Lys Thr Asp Gly Lys Glu Leu Ala Gly Thr Met Asp Gly Glu Gly Thr 
            20                  25                  30          


Leu Phe Gln Thr Glu Ser Pro Gln Ser Gly Ser Ile Leu Thr Glu Glu 
        35                  40                  45              


Thr Glu Val Lys Gly Thr Leu Glu Gly Asp Val Cys Gly Val Glu Pro 
    50                  55                  60                  


Pro Gly Pro Gly Asp Thr Val Val Gln Gly Asp Leu Gln Glu Thr Thr 
65                  70                  75                  80  


Val Val Thr Gly Leu Gly Pro Asp Thr Gln Asp Leu Glu Gly Gln Ser 
                85                  90                  95      


Pro Pro Gln Ser Leu Pro Ser Thr Pro Lys Ala Ala Trp Ile Arg Glu 
            100                 105                 110         


Glu Gly Arg Cys Ser Ser Ser Asp Asp Asp Thr Asp Val Asp Met Glu 
        115                 120                 125             


Gly Leu Arg Arg Arg Arg Gly Arg Glu Ala Gly Pro Pro Gln Pro Met 
    130                 135                 140                 


Val Pro Leu Ala Val Glu Asn Gln Ala Gly Gly Glu Gly Ala Gly Gly 
145                 150                 155                 160 


Glu Leu Gly Ile Ser Leu Asn Met Cys Leu Leu Gly Ala Leu Val Leu 
                165                 170                 175     


Leu Gly Leu Gly Val Leu Leu Phe Ser Gly Gly Leu Ser Glu Ser Glu 
            180                 185                 190         


Thr Gly Pro Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu 
        195                 200                 205             


Val Leu Glu Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu 
    210                 215                 220                 


Gln Ala Pro Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly 
225                 230                 235                 240 


Leu Leu Leu Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu 
                245                 250                 255     


Gln Ala Gln Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu Met His 
            260                 265                 270         


Gln Pro Lys Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly Ala Leu 
        275                 280                 285             


Gln Gln Gly Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu Gln Gln 
    290                 295                 300                 


Leu Arg Ala Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg Gly Pro 
305                 310                 315                 320 


Asp Gly Val Cys Leu Ser Gly Gly Arg Gly Pro Gln Gly Asp Lys Ala 
                325                 330                 335     


Ile Arg Glu Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser Phe Leu 
            340                 345                 350         


Lys Gln Lys Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg Gln Glu 
        355                 360                 365             


Leu Glu Arg Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp Leu Glu 
    370                 375                 380                 


Arg Ser Leu Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala Gly Leu 
385                 390                 395                 400 


Ala Glu Leu Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu Glu Asn 
                405                 410                 415     


Trp Gly Gln Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala Trp His 
            420                 425                 430         


Gln Lys Ser His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys Glu Lys 
        435                 440                 445             


Trp Trp Asp Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys His Lys 
    450                 455                 460                 


Lys Glu Glu Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly Gln Glu 
465                 470                 475                 480 


Asp Arg Glu Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg Val Glu 
                485                 490                 495     


Glu Ser Gly Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys Glu Pro 
            500                 505                 510         


Pro Arg Lys Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln Lys Gln 
        515                 520                 525             


Pro Arg Trp Arg Glu Gly Thr Lys Asp Ser His Asp Pro Leu Pro Ser 
    530                 535                 540                 


Trp Ala Glu Leu Leu Arg Pro Lys Tyr Arg Ala Pro Gln Gly Cys Ser 
545                 550                 555                 560 


Gly Val Asp Glu Cys Ala Arg Gln Glu Gly Leu Thr Phe Phe Gly Thr 
                565                 570                 575     


Glu Leu Ala Pro Val Arg Gln Gln Glu Leu Ala Ser Leu Leu Arg Thr 
            580                 585                 590         


Tyr Leu Ala Arg Leu Pro Trp Ala Gly Gln Leu Thr Lys Glu Leu Pro 
        595                 600                 605             


Leu Ser Pro Ala Phe Phe Gly Glu Asp Gly Ile Phe Arg His Asp Arg 
    610                 615                 620                 


Leu Arg Phe Arg Asp Phe Val Asp Ala Leu Glu Asp Ser Leu Glu Glu 
625                 630                 635                 640 


Val Ala Val Gln Gln Thr Gly Asp Asp Asp Glu Val Asp Asp Phe Glu 
                645                 650                 655     


Asp Phe Ile Phe Ser His Phe Phe Gly Asp Lys Ala Leu Lys Lys Arg 
            660                 665                 670         


Ser Gly Lys Lys Asp Lys His Ser Gln Ser Pro Arg Ala Ala Gly Pro 
        675                 680                 685             


Arg Glu Gly His Ser His Ser His His His His His Arg Gly 
    690                 695                 700         


<210> 6169
<211> 808
<212> PRT
<213> Homo sapiens

<400> 6169
Met Ile Trp Arg Asn Asn Trp Lys Ser Thr Thr Gly Arg Leu Asn Val 
1               5                   10                  15      


Lys Leu Gln Ser Asp Lys Leu Gln His Gly Cys Gly Pro Asp Tyr Ser 
            20                  25                  30          


Ser Ala Trp Leu Pro Ala Asn Glu Ser Leu Trp Gln Ala Thr Thr Val 
        35                  40                  45              


Pro Ser Asn His Arg Asn Asn His Ile Arg Arg His Ser Ile Ala Ser 
    50                  55                  60                  


Asp Ser Gly Asp Thr Gly Ile Gly Thr Ser Cys Ser Asp Ser Val Glu 
65                  70                  75                  80  


Asp His Ser Thr Ser Ser Gly Thr Leu Ser Phe Lys Pro Ser Gln Ser 
                85                  90                  95      


Leu Ile Thr Leu Pro Thr Ala His Val Met Pro Ser Asn Ser Ser Ala 
            100                 105                 110         


Ser Ile Ser Lys Leu Arg Glu Ser Leu Thr Pro Asp Gly Ser Lys Trp 
        115                 120                 125             


Ser Thr Ser Leu Met Gln Thr Leu Gly Asn His Ser Arg Gly Glu Gln 
    130                 135                 140                 


Asp Ser Ser Leu Asp Met Lys Asp Phe Arg Pro Leu Arg Lys Trp Ser 
145                 150                 155                 160 


Ser Leu Ser Lys Leu Thr Ala Pro Asp Asn Cys Gly Gln Gly Gly Thr 
                165                 170                 175     


Val Cys Arg Glu Glu Ser Arg Asn Gly Leu Glu Lys Ile Gly Lys Ala 
            180                 185                 190         


Lys Ala Leu Thr Ser Gln Leu Arg Thr Ile Gly Pro Ser Cys Leu His 
        195                 200                 205             


Asp Ser Met Glu Met Leu Arg Leu Glu Asp Lys Glu Ile Asn Lys Lys 
    210                 215                 220                 


Arg Ser Ser Thr Leu Asp Cys Lys Tyr Lys Phe Glu Ser Cys Ser Lys 
225                 230                 235                 240 


Glu Asp Phe Arg Ala Ser Ser Ser Thr Leu Arg Arg Gln Pro Val Asp 
                245                 250                 255     


Met Thr Tyr Ser Ala Leu Pro Glu Ser Lys Pro Ile Met Thr Ser Ser 
            260                 265                 270         


Glu Ala Phe Glu Pro Pro Lys Tyr Leu Met Leu Gly Gln Gln Ala Val 
        275                 280                 285             


Gly Gly Val Pro Ile Gln Pro Ser Val Arg Thr Gln Met Trp Leu Thr 
    290                 295                 300                 


Glu Gln Leu Arg Thr Asn Pro Leu Glu Gly Arg Asn Thr Glu Asp Ser 
305                 310                 315                 320 


Tyr Ser Leu Ala Pro Trp Gln Gln Gln Gln Ile Glu Asp Phe Arg Gln 
                325                 330                 335     


Gly Ser Glu Thr Pro Met Gln Val Leu Thr Gly Ser Ser Arg Gln Ser 
            340                 345                 350         


Tyr Ser Pro Gly Tyr Gln Asp Phe Ser Lys Trp Glu Ser Met Leu Lys 
        355                 360                 365             


Ile Lys Glu Gly Leu Leu Arg Gln Lys Glu Ile Val Ile Asp Arg Gln 
    370                 375                 380                 


Lys Gln Gln Ile Thr His Leu His Glu Arg Ile Arg Asp Asn Glu Leu 
385                 390                 395                 400 


Arg Ala Gln His Ala Met Leu Gly His Tyr Val Asn Cys Glu Asp Ser 
                405                 410                 415     


Tyr Val Ala Ser Leu Gln Pro Gln Tyr Glu Asn Thr Ser Leu Gln Thr 
            420                 425                 430         


Pro Phe Ser Glu Glu Ser Val Ser His Ser Gln Gln Gly Glu Phe Glu 
        435                 440                 445             


Gln Lys Leu Ala Ser Thr Glu Lys Glu Val Leu Gln Leu Asn Glu Phe 
    450                 455                 460                 


Leu Lys Gln Arg Leu Ser Leu Phe Ser Glu Glu Lys Lys Lys Leu Glu 
465                 470                 475                 480 


Glu Lys Leu Lys Thr Arg Asp Arg Tyr Ile Ser Ser Leu Lys Lys Lys 
                485                 490                 495     


Cys Gln Lys Glu Ser Glu Gln Asn Lys Glu Lys Gln Arg Arg Ile Glu 
            500                 505                 510         


Thr Leu Glu Lys Tyr Leu Ala Asp Leu Pro Thr Leu Asp Asp Val Gln 
        515                 520                 525             


Ser Gln Ser Leu Gln Leu Gln Ile Leu Glu Glu Lys Asn Lys Asn Leu 
    530                 535                 540                 


Gln Glu Ala Leu Ile Asp Thr Glu Lys Lys Leu Glu Glu Ile Lys Lys 
545                 550                 555                 560 


Gln Cys Gln Asp Lys Glu Thr Gln Leu Ile Cys Gln Lys Lys Lys Glu 
                565                 570                 575     


Lys Glu Leu Val Thr Thr Val Gln Ser Leu Gln Gln Lys Val Glu Arg 
            580                 585                 590         


Cys Leu Glu Asp Gly Ile Arg Leu Pro Met Leu Asp Ala Lys Gln Leu 
        595                 600                 605             


Gln Asn Glu Asn Asp Asn Leu Arg Gln Gln Asn Glu Thr Ala Ser Lys 
    610                 615                 620                 


Ile Ile Asp Ser Gln Gln Asp Glu Ile Asp Arg Met Ile Leu Glu Ile 
625                 630                 635                 640 


Gln Ser Met Gln Gly Lys Leu Ser Lys Glu Lys Leu Thr Thr Gln Lys 
                645                 650                 655     


Met Met Glu Glu Leu Glu Lys Lys Glu Arg Asn Val Gln Arg Leu Thr 
            660                 665                 670         


Lys Ala Leu Leu Glu Asn Gln Arg Gln Thr Asp Glu Thr Cys Ser Leu 
        675                 680                 685             


Leu Asp Gln Gly Gln Glu Pro Asp Gln Ser Arg Gln Gln Thr Val Leu 
    690                 695                 700                 


Ser Lys Arg Pro Leu Phe Asp Leu Thr Val Ile Asp Gln Leu Phe Lys 
705                 710                 715                 720 


Glu Met Ser Cys Cys Leu Phe Asp Leu Lys Ala Leu Cys Ser Ile Leu 
                725                 730                 735     


Asn Gln Arg Ala Gln Gly Lys Glu Pro Asn Leu Ser Leu Leu Leu Gly 
            740                 745                 750         


Ile Arg Ser Met Asn Cys Ser Ala Glu Glu Thr Glu Asn Asp His Ser 
        755                 760                 765             


Thr Glu Thr Leu Thr Lys Lys Leu Ser Asp Val Cys Gln Leu Arg Arg 
    770                 775                 780                 


Asp Ile Asp Glu Leu Arg Thr Thr Ile Ser Asp Arg Tyr Ala Gln Asp 
785                 790                 795                 800 


Met Gly Asp Asn Cys Ile Thr Gln 
                805             


<210> 6170
<211> 805
<212> PRT
<213> Homo sapiens

<400> 6170
Met Trp Gly Arg Phe Leu Ala Pro Glu Ala Ser Gly Arg Asp Ser Pro 
1               5                   10                  15      


Gly Gly Ala Arg Ser Phe Pro Ala Gly Pro Asp Tyr Ser Ser Ala Trp 
            20                  25                  30          


Leu Pro Ala Asn Glu Ser Leu Trp Gln Ala Thr Thr Val Pro Ser Asn 
        35                  40                  45              


His Arg Asn Asn His Ile Arg Arg His Ser Ile Ala Ser Asp Ser Gly 
    50                  55                  60                  


Asp Thr Gly Ile Gly Thr Ser Cys Ser Asp Ser Val Glu Asp His Ser 
65                  70                  75                  80  


Thr Ser Ser Gly Thr Leu Ser Phe Lys Pro Ser Gln Ser Leu Ile Thr 
                85                  90                  95      


Leu Pro Thr Ala His Val Met Pro Ser Asn Ser Ser Ala Ser Ile Ser 
            100                 105                 110         


Lys Leu Arg Glu Ser Leu Thr Pro Asp Gly Ser Lys Trp Ser Thr Ser 
        115                 120                 125             


Leu Met Gln Thr Leu Gly Asn His Ser Arg Gly Glu Gln Asp Ser Ser 
    130                 135                 140                 


Leu Asp Met Lys Asp Phe Arg Pro Leu Arg Lys Trp Ser Ser Leu Ser 
145                 150                 155                 160 


Lys Leu Thr Ala Pro Asp Asn Cys Gly Gln Gly Gly Thr Val Cys Arg 
                165                 170                 175     


Glu Glu Ser Arg Asn Gly Leu Glu Lys Ile Gly Lys Ala Lys Ala Leu 
            180                 185                 190         


Thr Ser Gln Leu Arg Thr Ile Gly Pro Ser Cys Leu His Asp Ser Met 
        195                 200                 205             


Glu Met Leu Arg Leu Glu Asp Lys Glu Ile Asn Lys Lys Arg Ser Ser 
    210                 215                 220                 


Thr Leu Asp Cys Lys Tyr Lys Phe Glu Ser Cys Ser Lys Glu Asp Phe 
225                 230                 235                 240 


Arg Ala Ser Ser Ser Thr Leu Arg Arg Gln Pro Val Asp Met Thr Tyr 
                245                 250                 255     


Ser Ala Leu Pro Glu Ser Lys Pro Ile Met Thr Ser Ser Glu Ala Phe 
            260                 265                 270         


Glu Pro Pro Lys Tyr Leu Met Leu Gly Gln Gln Ala Val Gly Gly Val 
        275                 280                 285             


Pro Ile Gln Pro Ser Val Arg Thr Gln Met Trp Leu Thr Glu Gln Leu 
    290                 295                 300                 


Arg Thr Asn Pro Leu Glu Gly Arg Asn Thr Glu Asp Ser Tyr Ser Leu 
305                 310                 315                 320 


Ala Pro Trp Gln Gln Gln Gln Ile Glu Asp Phe Arg Gln Gly Ser Glu 
                325                 330                 335     


Thr Pro Met Gln Val Leu Thr Gly Ser Ser Arg Gln Ser Tyr Ser Pro 
            340                 345                 350         


Gly Tyr Gln Asp Phe Ser Lys Trp Glu Ser Met Leu Lys Ile Lys Glu 
        355                 360                 365             


Gly Leu Leu Arg Gln Lys Glu Ile Val Ile Asp Arg Gln Lys Gln Gln 
    370                 375                 380                 


Ile Thr His Leu His Glu Arg Ile Arg Asp Asn Glu Leu Arg Ala Gln 
385                 390                 395                 400 


His Ala Met Leu Gly His Tyr Val Asn Cys Glu Asp Ser Tyr Val Ala 
                405                 410                 415     


Ser Leu Gln Pro Gln Tyr Glu Asn Thr Ser Leu Gln Thr Pro Phe Ser 
            420                 425                 430         


Glu Glu Ser Val Ser His Ser Gln Gln Gly Glu Phe Glu Gln Lys Leu 
        435                 440                 445             


Ala Ser Thr Glu Lys Glu Val Leu Gln Leu Asn Glu Phe Leu Lys Gln 
    450                 455                 460                 


Arg Leu Ser Leu Phe Ser Glu Glu Lys Lys Lys Leu Glu Glu Lys Leu 
465                 470                 475                 480 


Lys Thr Arg Asp Arg Tyr Ile Ser Ser Leu Lys Lys Lys Cys Gln Lys 
                485                 490                 495     


Glu Ser Glu Gln Asn Lys Glu Lys Gln Arg Arg Ile Glu Thr Leu Glu 
            500                 505                 510         


Lys Tyr Leu Ala Asp Leu Pro Thr Leu Asp Asp Val Gln Ser Gln Ser 
        515                 520                 525             


Leu Gln Leu Gln Ile Leu Glu Glu Lys Asn Lys Asn Leu Gln Glu Ala 
    530                 535                 540                 


Leu Ile Asp Thr Glu Lys Lys Leu Glu Glu Ile Lys Lys Gln Cys Gln 
545                 550                 555                 560 


Asp Lys Glu Thr Gln Leu Ile Cys Gln Lys Lys Lys Glu Lys Glu Leu 
                565                 570                 575     


Val Thr Thr Val Gln Ser Leu Gln Gln Lys Val Glu Arg Cys Leu Glu 
            580                 585                 590         


Asp Gly Ile Arg Leu Pro Met Leu Asp Ala Lys Gln Leu Gln Asn Glu 
        595                 600                 605             


Asn Asp Asn Leu Arg Gln Gln Asn Glu Thr Ala Ser Lys Ile Ile Asp 
    610                 615                 620                 


Ser Gln Gln Asp Glu Ile Asp Arg Met Ile Leu Glu Ile Gln Ser Met 
625                 630                 635                 640 


Gln Gly Lys Leu Ser Lys Glu Lys Leu Thr Thr Gln Lys Met Met Glu 
                645                 650                 655     


Glu Leu Glu Lys Lys Glu Arg Asn Val Gln Arg Leu Thr Lys Ala Leu 
            660                 665                 670         


Leu Glu Asn Gln Arg Gln Thr Asp Glu Thr Cys Ser Leu Leu Asp Gln 
        675                 680                 685             


Gly Gln Glu Pro Asp Gln Ser Arg Gln Gln Thr Val Leu Ser Lys Arg 
    690                 695                 700                 


Pro Leu Phe Asp Leu Thr Val Ile Asp Gln Leu Phe Lys Glu Met Ser 
705                 710                 715                 720 


Cys Cys Leu Phe Asp Leu Lys Ala Leu Cys Ser Ile Leu Asn Gln Arg 
                725                 730                 735     


Ala Gln Gly Lys Glu Pro Asn Leu Ser Leu Leu Leu Gly Ile Arg Ser 
            740                 745                 750         


Met Asn Cys Ser Ala Glu Glu Thr Glu Asn Asp His Ser Thr Glu Thr 
        755                 760                 765             


Leu Thr Lys Lys Leu Ser Asp Val Cys Gln Leu Arg Arg Asp Ile Asp 
    770                 775                 780                 


Glu Leu Arg Thr Thr Ile Ser Asp Arg Tyr Ala Gln Asp Met Gly Asp 
785                 790                 795                 800 


Asn Cys Ile Thr Gln 
                805 


<210> 6171
<211> 495
<212> PRT
<213> Homo sapiens

<400> 6171
Met Val Glu Glu His Glu Leu Arg Lys Glu Arg Ile Gln Glu Asp Tyr 
1               5                   10                  15      


Asn Asp Lys Tyr Trp Asp Gln Arg Tyr Thr Ile Val Gln Gln Gln Ile 
            20                  25                  30          


Pro Ser Phe Leu Gln Lys Met Ala Asp Lys Ile Leu Ser Thr Gly Lys 
        35                  40                  45              


Tyr Leu Asn Val Val Arg Glu Cys Gly His Asp Val Thr Cys Pro Val 
    50                  55                  60                  


Ala Lys Glu Ile Ile Tyr Thr Leu Lys Glu Arg Ala Tyr Val Glu Gln 
65                  70                  75                  80  


Ile Glu Lys Ala Phe Asn Tyr Ala Ser Lys Val Leu Leu Asp Phe Leu 
                85                  90                  95      


Met Glu Glu Lys Glu Leu Val Ala His Leu Arg Ser Ile Lys Arg Tyr 
            100                 105                 110         


Phe Leu Met Asp Gln Gly Asp Phe Phe Val His Phe Met Asp Leu Ala 
        115                 120                 125             


Glu Glu Glu Leu Arg Lys Pro Val Glu Asp Ile Thr Pro Pro Arg Leu 
    130                 135                 140                 


Glu Ala Leu Leu Glu Leu Ala Leu Arg Met Ser Thr Ala Asn Thr Asp 
145                 150                 155                 160 


Pro Phe Lys Asp Asp Leu Lys Ile Asp Leu Met Pro His Asp Leu Ile 
                165                 170                 175     


Thr Gln Leu Leu Arg Val Leu Ala Ile Glu Thr Lys Gln Glu Lys Ala 
            180                 185                 190         


Met Ala His Ala Asp Pro Thr Glu Leu Ala Leu Ser Gly Leu Glu Ala 
        195                 200                 205             


Phe Ser Phe Asp Tyr Ile Val Lys Trp Pro Leu Ser Leu Ile Ile Asn 
    210                 215                 220                 


Arg Lys Ala Leu Thr Arg Tyr Gln Met Leu Phe Arg His Met Phe Tyr 
225                 230                 235                 240 


Cys Lys His Val Glu Arg Gln Leu Cys Ser Val Trp Ile Ser Asn Lys 
                245                 250                 255     


Thr Ala Lys Gln His Ser Leu His Ser Ala Gln Trp Phe Ala Gly Ala 
            260                 265                 270         


Phe Thr Leu Arg Gln Arg Met Leu Asn Phe Val Gln Asn Ile Gln Tyr 
        275                 280                 285             


Tyr Met Met Phe Glu Val Met Glu Pro Thr Trp His Ile Leu Glu Lys 
    290                 295                 300                 


Asn Leu Lys Ser Ala Ser Asn Ile Asp Asp Val Leu Gly His His Thr 
305                 310                 315                 320 


Gly Phe Leu Asp Thr Cys Leu Lys Asp Cys Met Leu Thr Asn Pro Glu 
                325                 330                 335     


Leu Leu Lys Val Phe Ser Lys Leu Met Ser Val Cys Val Met Phe Thr 
            340                 345                 350         


Asn Cys Met Gln Lys Phe Thr Gln Ser Met Lys Leu Asp Gly Glu Leu 
        355                 360                 365             


Gly Gly Gln Thr Leu Glu His Ser Thr Val Leu Gly Leu Pro Ala Gly 
    370                 375                 380                 


Ala Glu Glu Arg Ala Arg Lys Glu Leu Ala Arg Lys His Leu Ala Glu 
385                 390                 395                 400 


His Ala Asp Thr Val Gln Leu Val Ser Gly Phe Glu Ala Thr Ile Asn 
                405                 410                 415     


Lys Phe Asp Lys Asn Phe Ser Ala His Leu Leu Asp Leu Leu Ala Arg 
            420                 425                 430         


Leu Ser Ile Tyr Ser Thr Ser Asp Cys Glu His Gly Met Ala Ser Val 
        435                 440                 445             


Ile Ser Arg Leu Asp Phe Asn Gly Phe Tyr Thr Glu Arg Leu Glu Arg 
    450                 455                 460                 


Leu Ser Ala Glu Arg Ser Gln Lys Ala Thr Pro Gln Val Pro Val Leu 
465                 470                 475                 480 


Arg Gly Pro Pro Ala Pro Ala Pro Arg Val Ala Val Thr Ala Gln 
                485                 490                 495 


<210> 6172
<211> 902
<212> PRT
<213> Homo sapiens

<400> 6172
Met Ser Glu Phe Arg Ile His His Asp Val Asn Glu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Arg Val His Gly Gly Asp Gly Ala Glu Val Tyr Ile Asp Leu Leu 
            20                  25                  30          


Gln Lys Asn Arg Thr Pro Tyr Val Thr Thr Thr Val Ser Ala His Ser 
        35                  40                  45              


Ala Lys Val Lys Ile Ala Glu Phe Ser Arg Thr Pro Glu Asp Phe Leu 
    50                  55                  60                  


Lys Lys Tyr Asp Glu Leu Lys Ser Lys Asn Thr Arg Asn Leu Asp Pro 
65                  70                  75                  80  


Leu Val Tyr Leu Leu Ser Lys Leu Thr Glu Asp Lys Glu Thr Leu Gln 
                85                  90                  95      


Tyr Leu Gln Gln Asn Ala Lys Glu Arg Ala Glu Leu Ala Ala Ala Ala 
            100                 105                 110         


Val Gly Ser Ser Thr Thr Ser Ile Asn Val Pro Ala Ala Ala Ser Lys 
        115                 120                 125             


Ile Ser Met Gln Glu Leu Glu Glu Leu Arg Lys Gln Leu Gly Ser Val 
    130                 135                 140                 


Ala Thr Gly Ser Thr Leu Gln Gln Ser Leu Glu Leu Lys Arg Lys Met 
145                 150                 155                 160 


Leu Arg Asp Lys Gln Asn Lys Lys Asn Ser Gly Gln His Leu Pro Ile 
                165                 170                 175     


Phe Pro Ala Trp Val Tyr Glu Arg Pro Ala Leu Ile Gly Asp Phe Leu 
            180                 185                 190         


Ile Gly Ala Gly Ile Ser Thr Asp Thr Ala Leu Pro Ile Gly Thr Leu 
        195                 200                 205             


Pro Leu Ala Ser Gln Glu Ser Ala Val Val Glu Asp Leu Leu Tyr Val 
    210                 215                 220                 


Leu Val Gly Val Asp Gly Arg Tyr Val Ser Ala Gln Pro Leu Ala Gly 
225                 230                 235                 240 


Arg Gln Ser Arg Thr Phe Leu Val Asp Pro Asn Leu Asp Leu Ser Ile 
                245                 250                 255     


Arg Glu Leu Val His Arg Ile Leu Pro Val Ala Ala Ser Tyr Ser Ala 
            260                 265                 270         


Val Thr Arg Phe Ile Glu Glu Lys Ser Ser Phe Glu Tyr Gly Gln Val 
        275                 280                 285             


Asn His Ala Leu Ala Ala Ala Met Arg Thr Leu Val Lys Glu His Leu 
    290                 295                 300                 


Ile Leu Val Ser Gln Leu Glu Gln Leu His Arg Gln Gly Leu Leu Ser 
305                 310                 315                 320 


Leu Gln Lys Leu Trp Phe Tyr Ile Gln Pro Ala Met Arg Thr Met Asp 
                325                 330                 335     


Ile Leu Ala Ser Leu Ala Thr Ser Val Asp Lys Gly Glu Cys Leu Gly 
            340                 345                 350         


Gly Ser Thr Leu Ser Leu Leu His Asp Arg Ser Phe Ser Tyr Thr Gly 
        355                 360                 365             


Asp Ser Gln Ala Gln Glu Leu Cys Leu Tyr Leu Thr Lys Ala Ala Ser 
    370                 375                 380                 


Ala Pro Tyr Phe Glu Val Leu Glu Lys Trp Ile Tyr Arg Gly Ile Ile 
385                 390                 395                 400 


His Asp Pro Tyr Ser Glu Phe Met Val Glu Glu His Glu Leu Arg Lys 
                405                 410                 415     


Glu Arg Ile Gln Glu Asp Tyr Asn Asp Lys Tyr Trp Asp Gln Arg Tyr 
            420                 425                 430         


Thr Ile Val Gln Gln Gln Ile Pro Ser Phe Leu Gln Lys Met Ala Asp 
        435                 440                 445             


Lys Ile Leu Ser Thr Gly Lys Tyr Leu Asn Val Val Arg Glu Cys Gly 
    450                 455                 460                 


His Asp Val Thr Cys Pro Val Ala Lys Glu Ile Ile Tyr Thr Leu Lys 
465                 470                 475                 480 


Glu Arg Ala Tyr Val Glu Gln Ile Glu Lys Ala Phe Asn Tyr Ala Ser 
                485                 490                 495     


Lys Val Leu Leu Asp Phe Leu Met Glu Glu Lys Glu Leu Val Ala His 
            500                 505                 510         


Leu Arg Ser Ile Lys Arg Tyr Phe Leu Met Asp Gln Gly Asp Phe Phe 
        515                 520                 525             


Val His Phe Met Asp Leu Ala Glu Glu Glu Leu Arg Lys Pro Val Glu 
    530                 535                 540                 


Asp Ile Thr Pro Pro Arg Leu Glu Ala Leu Leu Glu Leu Ala Leu Arg 
545                 550                 555                 560 


Met Ser Thr Ala Asn Thr Asp Pro Phe Lys Asp Asp Leu Lys Ile Asp 
                565                 570                 575     


Leu Met Pro His Asp Leu Ile Thr Gln Leu Leu Arg Val Leu Ala Ile 
            580                 585                 590         


Glu Thr Lys Gln Glu Lys Ala Met Ala His Ala Asp Pro Thr Glu Leu 
        595                 600                 605             


Ala Leu Ser Gly Leu Glu Ala Phe Ser Phe Asp Tyr Ile Val Lys Trp 
    610                 615                 620                 


Pro Leu Ser Leu Ile Ile Asn Arg Lys Ala Leu Thr Arg Tyr Gln Met 
625                 630                 635                 640 


Leu Phe Arg His Met Phe Tyr Cys Lys His Val Glu Arg Gln Leu Cys 
                645                 650                 655     


Ser Val Trp Ile Ser Asn Lys Thr Ala Lys Gln His Ser Leu His Ser 
            660                 665                 670         


Ala Gln Trp Phe Ala Gly Ala Phe Thr Leu Arg Gln Arg Met Leu Asn 
        675                 680                 685             


Phe Val Gln Asn Ile Gln Tyr Tyr Met Met Phe Glu Val Met Glu Pro 
    690                 695                 700                 


Thr Trp His Ile Leu Glu Lys Asn Leu Lys Ser Ala Ser Asn Ile Asp 
705                 710                 715                 720 


Asp Val Leu Gly His His Thr Gly Phe Leu Asp Thr Cys Leu Lys Asp 
                725                 730                 735     


Cys Met Leu Thr Asn Pro Glu Leu Leu Lys Val Phe Ser Lys Leu Met 
            740                 745                 750         


Ser Val Cys Val Met Phe Thr Asn Cys Met Gln Lys Phe Thr Gln Ser 
        755                 760                 765             


Met Lys Leu Asp Gly Glu Leu Gly Gly Gln Thr Leu Glu His Ser Thr 
    770                 775                 780                 


Val Leu Gly Leu Pro Ala Gly Ala Glu Glu Arg Ala Arg Lys Glu Leu 
785                 790                 795                 800 


Ala Arg Lys His Leu Ala Glu His Ala Asp Thr Val Gln Leu Val Ser 
                805                 810                 815     


Gly Phe Glu Ala Thr Ile Asn Lys Phe Asp Lys Asn Phe Ser Ala His 
            820                 825                 830         


Leu Leu Asp Leu Leu Ala Arg Leu Ser Ile Tyr Ser Thr Ser Asp Cys 
        835                 840                 845             


Glu His Gly Met Ala Ser Val Ile Ser Arg Leu Asp Phe Asn Gly Phe 
    850                 855                 860                 


Tyr Thr Glu Arg Leu Glu Arg Leu Ser Ala Glu Arg Ser Gln Lys Ala 
865                 870                 875                 880 


Thr Pro Gln Val Pro Val Leu Arg Gly Pro Pro Ala Pro Ala Pro Arg 
                885                 890                 895     


Val Ala Val Thr Ala Gln 
            900         


<210> 6173
<211> 539
<212> PRT
<213> Homo sapiens

<400> 6173
Met Asp Ala Met Ala Ser Pro Gly Lys Asp Asn Tyr Arg Met Lys Ser 
1               5                   10                  15      


Tyr Lys Asn Lys Ala Leu Asn Pro Gln Glu Met Arg Arg Arg Arg Glu 
            20                  25                  30          


Glu Glu Gly Ile Gln Leu Arg Lys Gln Lys Arg Glu Glu Gln Leu Phe 
        35                  40                  45              


Lys Arg Arg Asn Val Tyr Leu Pro Arg Asn Asp Glu Ser Met Leu Glu 
    50                  55                  60                  


Ser Pro Ile Gln Asp Pro Asp Ile Ser Ser Thr Val Pro Ile Pro Glu 
65                  70                  75                  80  


Glu Glu Val Val Thr Thr Asp Met Val Gln Met Ile Phe Ser Asn Asn 
                85                  90                  95      


Ala Asp Gln Gln Leu Thr Ala Thr Gln Lys Phe Arg Lys Leu Leu Ser 
            100                 105                 110         


Lys Glu Pro Asn Pro Pro Ile Asp Gln Val Ile Gln Lys Pro Gly Val 
        115                 120                 125             


Val Gln Arg Phe Val Lys Phe Leu Glu Arg Asn Glu Asn Cys Thr Leu 
    130                 135                 140                 


Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser Gly Thr Phe 
145                 150                 155                 160 


Leu His Thr Lys Val Val Ile Glu Thr Gly Ala Val Pro Ile Phe Ile 
                165                 170                 175     


Lys Leu Leu Asn Ser Glu His Glu Asp Val Gln Glu Gln Ala Val Trp 
            180                 185                 190         


Ala Leu Gly Asn Ile Ala Gly Asp Asn Ala Glu Cys Arg Asp Phe Val 
        195                 200                 205             


Leu Asn Cys Glu Ile Leu Pro Pro Leu Leu Glu Leu Leu Thr Asn Ser 
    210                 215                 220                 


Asn Arg Leu Thr Thr Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu 
225                 230                 235                 240 


Cys Arg Gly Lys Asn Pro Pro Pro Asn Phe Ser Lys Val Ser Pro Cys 
                245                 250                 255     


Leu Asn Val Leu Ser Arg Leu Leu Phe Ser Ser Asp Pro Asp Val Leu 
            260                 265                 270         


Ala Asp Val Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Asp 
        275                 280                 285             


Lys Ile Gln Ala Val Ile Asp Ser Gly Val Cys Arg Arg Leu Val Glu 
    290                 295                 300                 


Leu Leu Met His Asn Asp Tyr Lys Val Val Ser Pro Ala Leu Arg Ala 
305                 310                 315                 320 


Val Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu 
                325                 330                 335     


Asn Cys Ser Ala Leu Pro Cys Leu Leu His Leu Leu Ser Ser Pro Lys 
            340                 345                 350         


Glu Ser Ile Arg Lys Glu Ala Cys Trp Thr Val Ser Asn Ile Thr Ala 
        355                 360                 365             


Gly Asn Arg Ala Gln Ile Gln Ala Val Ile Asp Ala Asn Ile Phe Pro 
    370                 375                 380                 


Val Leu Ile Glu Ile Leu Gln Lys Ala Glu Phe Arg Thr Arg Lys Glu 
385                 390                 395                 400 


Ala Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Thr Pro Glu Gln 
                405                 410                 415     


Ile Arg Tyr Leu Val Ala Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu 
            420                 425                 430         


Leu Thr Val Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu 
        435                 440                 445             


Glu Asn Ile Leu Arg Leu Gly Glu Gln Glu Ser Lys Gln Asn Gly Ile 
    450                 455                 460                 


Gly Ile Asn Pro Tyr Cys Ala Leu Ile Glu Glu Ala Tyr Gly Leu Asp 
465                 470                 475                 480 


Lys Ile Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys 
                485                 490                 495     


Ala Phe Asp Leu Ile Glu His Tyr Phe Gly Val Glu Glu Asp Asp Pro 
            500                 505                 510         


Ser Ile Val Pro Gln Val Asp Glu Asn Gln Gln Gln Phe Ile Phe Gln 
        515                 520                 525             


Gln Gln Glu Ala Pro Met Asp Gly Phe Gln Leu 
    530                 535                 


<210> 6174
<211> 150
<212> PRT
<213> Homo sapiens

<400> 6174
Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg 
1               5                   10                  15      


Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe 
            20                  25                  30          


Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro 
        35                  40                  45              


Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu 
    50                  55                  60                  


Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys 
65                  70                  75                  80  


Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu 
                85                  90                  95      


Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr 
            100                 105                 110         


Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile 
        115                 120                 125             


Leu Pro Thr Cys Glu Cys Ala Cys Phe Trp Ser Trp Glu Gln Asn Ile 
    130                 135                 140                 


Ala Leu Gly Leu Gly Val 
145                 150 


<210> 6175
<211> 115
<212> PRT
<213> Homo sapiens

<400> 6175
Met Ala Phe Pro Arg Val Lys Pro Ala Pro Asp Glu Thr Ser Phe Ser 
1               5                   10                  15      


Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu Ala Pro Asn Ser Ala Glu 
            20                  25                  30          


Gln Ala Ser Ile Leu Ser Leu Val Thr Lys Ile Asn Asn Val Ile Asp 
        35                  40                  45              


Asn Leu Ile Val Ala Pro Gly Thr Phe Glu Val Gln Ile Glu Glu Val 
    50                  55                  60                  


Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr Met Thr Thr Gly His Asn 
65                  70                  75                  80  


Val Ala Asp Leu Val Val Ile Leu Lys Ile Leu Pro Thr Leu Glu Ala 
                85                  90                  95      


Val Ala Ala Leu Gly Asn Lys Val Val Glu Ser Leu Arg Ala Gln Asp 
            100                 105                 110         


Pro Ser Glu 
        115 


<210> 6176
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6176
Met Ser Asp Cys Tyr Thr Glu Leu Glu Lys Ala Val Ile Val Leu Val 
1               5                   10                  15      


Glu Asn Phe Tyr Lys Tyr Val Ser Lys Tyr Ser Leu Val Lys Asn Lys 
            20                  25                  30          


Ile Ser Lys Ser Ser Phe Arg Glu Met Leu Gln Lys Glu Leu Asn His 
        35                  40                  45              


Met Leu Ser Asp Thr Gly Asn Arg Lys Ala Ala Asp Lys Leu Ile Gln 
    50                  55                  60                  


Asn Leu Asp Ala Asn His Asp Gly Arg Ile Ser Phe Asp Glu Tyr Trp 
65                  70                  75                  80  


Thr Leu Ile Gly Gly Ile Thr Gly Pro Ile Ala Lys Leu Ile His Glu 
                85                  90                  95      


Gln Glu Gln Gln Ser Ser Ser 
            100             


<210> 6177
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6177
Met Ser Asp Cys Tyr Thr Glu Leu Glu Lys Ala Val Ile Val Leu Val 
1               5                   10                  15      


Glu Asn Phe Tyr Lys Tyr Val Ser Lys Tyr Ser Leu Val Lys Asn Lys 
            20                  25                  30          


Ile Ser Lys Ser Ser Phe Arg Glu Met Leu Gln Lys Glu Leu Asn His 
        35                  40                  45              


Met Leu Ser Asp Thr Gly Asn Arg Lys Ala Ala Asp Lys Leu Ile Gln 
    50                  55                  60                  


Asn Leu Asp Ala Asn His Asp Gly Arg Ile Ser Phe Asp Glu Tyr Trp 
65                  70                  75                  80  


Thr Leu Ile Gly Gly Ile Thr Gly Pro Ile Ala Lys Leu Ile His Glu 
                85                  90                  95      


Gln Glu Gln Gln Ser Ser Ser 
            100             


<210> 6178
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6178
Met Ser Asp Cys Tyr Thr Glu Leu Glu Lys Ala Val Ile Val Leu Val 
1               5                   10                  15      


Glu Asn Phe Tyr Lys Tyr Val Ser Lys Tyr Ser Leu Val Lys Asn Lys 
            20                  25                  30          


Ile Ser Lys Ser Ser Phe Arg Glu Met Leu Gln Lys Glu Leu Asn His 
        35                  40                  45              


Met Leu Ser Asp Thr Gly Asn Arg Lys Ala Ala Asp Lys Leu Ile Gln 
    50                  55                  60                  


Asn Leu Asp Ala Asn His Asp Gly Arg Ile Ser Phe Asp Glu Tyr Trp 
65                  70                  75                  80  


Thr Leu Ile Gly Gly Ile Thr Gly Pro Ile Ala Lys Leu Ile His Glu 
                85                  90                  95      


Gln Glu Gln Gln Ser Ser Ser 
            100             


<210> 6179
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6179
Met Ser Asp Cys Tyr Thr Glu Leu Glu Lys Ala Val Ile Val Leu Val 
1               5                   10                  15      


Glu Asn Phe Tyr Lys Tyr Val Ser Lys Tyr Ser Leu Val Lys Asn Lys 
            20                  25                  30          


Ile Ser Lys Ser Ser Phe Arg Glu Met Leu Gln Lys Glu Leu Asn His 
        35                  40                  45              


Met Leu Ser Asp Thr Gly Asn Arg Lys Ala Ala Asp Lys Leu Ile Gln 
    50                  55                  60                  


Asn Leu Asp Ala Asn His Asp Gly Arg Ile Ser Phe Asp Glu Tyr Trp 
65                  70                  75                  80  


Thr Leu Ile Gly Gly Ile Thr Gly Pro Ile Ala Lys Leu Ile His Glu 
                85                  90                  95      


Gln Glu Gln Gln Ser Ser Ser 
            100             


<210> 6180
<211> 101
<212> PRT
<213> Homo sapiens

<400> 6180
Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Gly Arg Asp Gly Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Ile His Tyr Leu Ala Thr Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Ala Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210> 6181
<211> 101
<212> PRT
<213> Homo sapiens

<400> 6181
Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Gly Arg Asp Gly Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Ile His Tyr Leu Ala Thr Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Ala Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210> 6182
<211> 73
<212> PRT
<213> Homo sapiens

<400> 6182
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Tyr Leu Pro Pro Pro Cys Pro Pro Glu His Cys Pro Pro 
        35                  40                  45              


Pro Pro Cys Gln Asp Lys Cys Pro Pro Val Gln Pro Tyr Pro Pro Cys 
    50                  55                  60                  


Gln Gln Lys Tyr Pro Pro Lys Ser Lys 
65                  70              


<210> 6183
<211> 72
<212> PRT
<213> Homo sapiens

<400> 6183
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210> 6184
<211> 72
<212> PRT
<213> Homo sapiens

<400> 6184
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210> 6185
<211> 72
<212> PRT
<213> Homo sapiens

<400> 6185
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Ser Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210> 6186
<211> 72
<212> PRT
<213> Homo sapiens

<400> 6186
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Ser Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210> 6187
<211> 72
<212> PRT
<213> Homo sapiens

<400> 6187
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Ser Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210> 6188
<211> 2850
<212> PRT
<213> Homo sapiens

<400> 6188
Met Pro Lys Leu Leu Gln Gly Val Ile Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Gln Tyr Ala Thr Gln His Gly Glu Tyr Asp Thr Leu Asn Lys Ala Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Asn Glu Phe His Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asn Asp Pro Asp Thr Val Asp Ile Ile Leu Gln Ser Leu Asp Arg Asp 
    50                  55                  60                  


His Asn Lys Lys Val Asp Phe Thr Glu Tyr Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Val Gln Ala Arg Asn Lys Ile Ile Gly Lys Asp Tyr Cys Gln Val 
                85                  90                  95      


Ser Gly Ser Lys Leu Arg Asp Asp Thr His Gln His Gln Glu Glu Gln 
            100                 105                 110         


Glu Glu Thr Glu Lys Glu Glu Asn Lys Arg Gln Glu Ser Ser Phe Ser 
        115                 120                 125             


His Ser Ser Trp Ser Ala Gly Glu Asn Asp Ser Tyr Ser Arg Asn Val 
    130                 135                 140                 


Arg Gly Ser Leu Lys Pro Gly Thr Glu Ser Ile Ser Arg Arg Leu Ser 
145                 150                 155                 160 


Phe Gln Arg Asp Phe Ser Gly Gln His Asn Ser Tyr Ser Gly Gln Ser 
                165                 170                 175     


Ser Ser Tyr Gly Glu Gln Asn Ser Asp Ser His Gln Ser Ser Gly Arg 
            180                 185                 190         


Gly Gln Cys Gly Ser Gly Ser Gly Gln Ser Pro Asn Tyr Gly Gln His 
        195                 200                 205             


Gly Ser Gly Ser Gly Gln Ser Ser Ser Asn Asp Thr His Gly Ser Gly 
    210                 215                 220                 


Ser Gly Gln Ser Ser Gly Phe Ser Gln His Lys Ser Ser Ser Gly Gln 
225                 230                 235                 240 


Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser Gly His Ser Ser Gly 
                245                 250                 255     


Tyr Gly Gln His Gly Ser Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg 
            260                 265                 270         


His Arg Ser Ser Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser 
        275                 280                 285             


Gly Ser Arg Gln Ser Leu Gly His Gly Arg Gln Gly Ser Gly Ser Arg 
    290                 295                 300                 


Gln Ser Pro Ser His Val Arg His Gly Ser Gly Ser Gly His Ser Ser 
305                 310                 315                 320 


Ser His Gly Gln His Gly Ser Gly Ser Ser Tyr Ser Tyr Ser Arg Gly 
                325                 330                 335     


His Tyr Glu Ser Gly Ser Gly Gln Thr Ser Gly Phe Gly Gln His Glu 
            340                 345                 350         


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Lys His Gly Ser Gly Ser 
        355                 360                 365             


Gly His Ser Ser Ser Gln Gly Gln His Gly Ser Thr Ser Gly Gln Ala 
    370                 375                 380                 


Ser Ser Ser Gly Gln His Gly Ser Ser Ser Arg Gln Ser Ser Ser Tyr 
385                 390                 395                 400 


Gly Gln His Glu Ser Ala Ser Arg His Ser Ser Gly Arg Gly Gln His 
                405                 410                 415     


Ser Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg Gly Ser Gly 
            420                 425                 430         


Ser Gly Gln Ser Pro Ser Ser Gly Gln His Gly Thr Gly Phe Gly Arg 
        435                 440                 445             


Ser Ser Ser Ser Gly Pro Tyr Val Ser Gly Ser Gly Tyr Ser Ser Gly 
    450                 455                 460                 


Phe Gly His His Glu Ser Ser Ser Glu His Ser Ser Gly Tyr Thr Gln 
465                 470                 475                 480 


His Gly Ser Gly Ser Gly His Ser Ser Gly His Gly Gln His Gly Ser 
                485                 490                 495     


Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg Gln Gly Ser Ser Ala Gly 
            500                 505                 510         


Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln Ser Leu 
        515                 520                 525             


Gly His Ser Arg His Gly Ser Gly Ser Gly Gln Ser Pro Ser Pro Ser 
    530                 535                 540                 


Arg Gly Arg His Glu Ser Gly Ser Arg Gln Ser Ser Ser Tyr Gly Pro 
545                 550                 555                 560 


His Gly Tyr Gly Ser Gly Arg Ser Ser Ser Arg Gly Pro Tyr Glu Ser 
                565                 570                 575     


Gly Ser Gly His Ser Ser Gly Leu Gly His Gln Glu Ser Arg Ser Gly 
            580                 585                 590         


Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser Ser Gly His Ser Ser 
        595                 600                 605             


Thr His Gly Gln His Gly Ser Thr Ser Gly Gln Ser Ser Ser Cys Gly 
    610                 615                 620                 


Gln His Gly Ala Thr Ser Gly Gln Ser Ser Ser His Gly Gln His Gly 
625                 630                 635                 640 


Ser Gly Ser Ser Gln Ser Ser Arg Tyr Gly Gln Gln Gly Ser Gly Ser 
                645                 650                 655     


Gly Gln Ser Pro Ser Arg Gly Arg His Gly Ser Asp Phe Gly His Ser 
            660                 665                 670         


Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Gly Trp Ser Ser Ser Asn 
        675                 680                 685             


Gly Pro His Gly Ser Val Ser Gly Gln Ser Ser Gly Phe Gly His Lys 
    690                 695                 700                 


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser 
705                 710                 715                 720 


Ser His Ser Ser Gly Tyr Arg Lys His Gly Ser Arg Ser Gly Gln Ser 
                725                 730                 735     


Ser Arg Ser Glu Gln His Gly Ser Ser Ser Gly Leu Ser Ser Ser Tyr 
            740                 745                 750         


Gly Gln His Gly Ser Gly Ser His Gln Ser Ser Gly His Gly Arg Gln 
        755                 760                 765             


Gly Ser Gly Ser Gly His Ser Pro Ser Arg Val Arg His Gly Ser Ser 
    770                 775                 780                 


Ser Gly His Ser Ser Ser His Gly Gln His Gly Ser Gly Thr Ser Cys 
785                 790                 795                 800 


Ser Ser Ser Cys Gly His Tyr Glu Ser Gly Ser Gly Gln Ala Ser Gly 
                805                 810                 815     


Phe Gly Gln His Glu Ser Gly Ser Gly Gln Gly Tyr Ser Gln His Gly 
            820                 825                 830         


Ser Ala Ser Gly His Phe Ser Ser Gln Gly Arg His Gly Ser Thr Ser 
        835                 840                 845             


Gly Gln Ser Ser Ser Ser Gly Gln His Asp Ser Ser Ser Gly Gln Ser 
    850                 855                 860                 


Ser Ser Tyr Gly Gln His Glu Ser Ala Ser His His Ala Ser Gly Arg 
865                 870                 875                 880 


Gly Arg His Gly Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg 
                885                 890                 895     


Gly Ser Gly Ser Gly Gln Ser Pro Ser Tyr Gly Arg His Gly Ser Gly 
            900                 905                 910         


Ser Gly Arg Ser Ser Ser Ser Gly Arg His Gly Ser Gly Ser Gly Gln 
        915                 920                 925             


Ser Ser Gly Phe Gly His Lys Ser Ser Ser Gly Gln Ser Ser Gly Tyr 
    930                 935                 940                 


Thr Gln His Gly Ser Gly Ser Gly His Ser Ser Ser Tyr Glu Gln His 
945                 950                 955                 960 


Gly Ser Arg Ser Gly Gln Ser Ser Arg Ser Glu Gln His Gly Ser Ser 
                965                 970                 975     


Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln 
            980                 985                 990         


Ser Leu Gly His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
        995                 1000                 1005             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    1010                 1015                 1020             


Tyr Gly  Pro Tyr Arg Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    1025                 1030                 1035             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    1040                 1045                 1050             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1055                 1060                 1065             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    1070                 1075                 1080             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    1085                 1090                 1095             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    1100                 1105                 1110             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    1115                 1120                 1125             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    1130                 1135                 1140             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    1145                 1150                 1155             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    1160                 1165                 1170             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    1175                 1180                 1185             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    1190                 1195                 1200             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    1205                 1210                 1215             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    1220                 1225                 1230             


Arg Gln  Gly Ser Gly Ser Gly  His Ser Pro Ser Arg  Gly Arg His 
    1235                 1240                 1245             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    1250                 1255                 1260             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser 
    1265                 1270                 1275             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    1280                 1285                 1290             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    1295                 1300                 1305             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    1310                 1315                 1320             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    1325                 1330                 1335             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    1340                 1345                 1350             


Ala Gly  Ser Gly Gln Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly 
    1355                 1360                 1365             


Ser Gly  His Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    1370                 1375                 1380             


Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser 
    1385                 1390                 1395             


Ser Gly  Phe Gly His His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly 
    1400                 1405                 1410             


Cys Thr  Gln His Gly Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu 
    1415                 1420                 1425             


Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His 
    1430                 1435                 1440             


Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser 
    1445                 1450                 1455             


Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln His Gly  Ser Gly Ser 
    1460                 1465                 1470             


Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser 
    1475                 1480                 1485             


Gly Gln  Ser Ser Ser Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp 
    1490                 1495                 1500             


Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly Ser Ser  His Ser Ser 
    1505                 1510                 1515             


Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr 
    1520                 1525                 1530             


Gly Gln  His Gly Ser Ser Ser  Gly His Ser Ser Thr  His Gly Gln 
    1535                 1540                 1545             


His Gly  Ser Thr Ser Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly 
    1550                 1555                 1560             


Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly Gln His  Gly Ser Gly 
    1565                 1570                 1575             


Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly 
    1580                 1585                 1590             


Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser 
    1595                 1600                 1605             


Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser 
    1610                 1615                 1620             


Ser Gly  Gln His Gly Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly 
    1625                 1630                 1635             


His His  Glu Ser Ser Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His 
    1640                 1645                 1650             


Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1655                 1660                 1665             


Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser 
    1670                 1675                 1680             


Arg Ser  Ser Ser Arg Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln 
    1685                 1690                 1695             


Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro 
    1700                 1705                 1710             


Ser Arg  Gly Arg His Gly Ser  Gly Leu Gly His Ser  Ser Ser His 
    1715                 1720                 1725             


Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro 
    1730                 1735                 1740             


Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val Phe Gly  Gln His Glu 
    1745                 1750                 1755             


Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly 
    1760                 1765                 1770             


Ser Gly  His Phe Cys Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly 
    1775                 1780                 1785             


Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser 
    1790                 1795                 1800             


Ser Ser  His Gly Gln His Gly  Ser Gly Ser Ser Gln  Ser Ser Ser 
    1805                 1810                 1815             


Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln Ser Pro  Ser Arg Gly 
    1820                 1825                 1830             


Arg His  Gly Ser Gly Ser Gly  His Ser Ser Ser Tyr  Gly Gln His 
    1835                 1840                 1845             


Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser 
    1850                 1855                 1860             


Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His His Glu  Ser Ser Ser 
    1865                 1870                 1875             


Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly Ser Gly  Ser Gly His 
    1880                 1885                 1890             


Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser 
    1895                 1900                 1905             


Arg Gly  Glu Gln His Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr 
    1910                 1915                 1920             


Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln 
    1925                 1930                 1935             


His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg 
    1940                 1945                 1950             


His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser Tyr Gly  Pro Tyr Gly 
    1955                 1960                 1965             


Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly 
    1970                 1975                 1980             


Ser Gly  His Ser Ser Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly 
    1985                 1990                 1995             


Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser Ser Ser  Gly His Ser 
    2000                 2005                 2010             


Ser Thr  His Gly Gln His Gly  Ser Ala Ser Gly Gln  Ser Ser Ser 
    2015                 2020                 2025             


Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly 
    2030                 2035                 2040             


Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln 
    2045                 2050                 2055             


Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser 
    2060                 2065                 2070             


Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser 
    2075                 2080                 2085             


Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly Pro Gly  Leu Gly Glu 
    2090                 2095                 2100             


Ser Ser  Gly Phe Gly His His  Glu Ser Ser Ser Gly  Gln Ser Ser 
    2105                 2110                 2115             


Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr 
    2120                 2125                 2130             


Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg 
    2135                 2140                 2145             


His Gly  Ser Ser Ser Gly Ser  Ser Ser Arg Tyr Gly  Gln His Gly 
    2150                 2155                 2160             


Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly 
    2165                 2170                 2175             


Ser Gly  His Ser Pro Ser Arg  Gly Arg His Gly Ser  Gly Ser Gly 
    2180                 2185                 2190             


His Ser  Ser Ser His Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser 
    2195                 2200                 2205             


Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val 
    2210                 2215                 2220             


Phe Gly  Gln His Glu Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser 
    2225                 2230                 2235             


Gln His  Gly Ser Gly Ser Gly  His Phe Cys Ser Gln  Gly Gln His 
    2240                 2245                 2250             


Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser 
    2255                 2260                 2265             


Ser Thr  Gly Gln Ser Ser Ser  His Gly Gln His Gly  Ser Gly Ser 
    2270                 2275                 2280             


Ser Gln  Ser Ser Ser Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln 
    2285                 2290                 2295             


Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly Ser Gly  His Ser Ser 
    2300                 2305                 2310             


Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser 
    2315                 2320                 2325             


Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His 
    2330                 2335                 2340             


His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly 
    2345                 2350                 2355             


Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg 
    2360                 2365                 2370             


Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His Gly Ser  Ser Ser Gly 
    2375                 2380                 2385             


Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser 
    2390                 2395                 2400             


Leu Gly  His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
    2405                 2410                 2415             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    2420                 2425                 2430             


Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    2435                 2440                 2445             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    2450                 2455                 2460             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    2465                 2470                 2475             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    2480                 2485                 2490             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    2495                 2500                 2505             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    2510                 2515                 2520             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    2525                 2530                 2535             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    2540                 2545                 2550             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    2555                 2560                 2565             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    2570                 2575                 2580             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    2585                 2590                 2595             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    2600                 2605                 2610             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    2615                 2620                 2625             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    2630                 2635                 2640             


Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro Ser Arg  Gly Arg His 
    2645                 2650                 2655             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    2660                 2665                 2670             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Leu 
    2675                 2680                 2685             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    2690                 2695                 2700             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    2705                 2710                 2715             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    2720                 2725                 2730             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    2735                 2740                 2745             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    2750                 2755                 2760             


Ala Gly  Ser Gly Gln Ser Leu  Ser His Gly Arg His  Gly Ser Gly 
    2765                 2770                 2775             


Ser Gly  Gln Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    2780                 2785                 2790             


Gln Ser  Ser Gly Tyr Ser Gln  His Gly Ser Gly Ser  Gly Gln Asp 
    2795                 2800                 2805             


Gly Tyr  Ser Tyr Cys Lys Gly  Gly Ser Asn His Asp  Gly Gly Ser 
    2810                 2815                 2820             


Ser Gly  Ser Tyr Phe Leu Ser  Phe Pro Ser Ser Thr  Ser Pro Tyr 
    2825                 2830                 2835             


Glu Tyr  Val Gln Glu Gln Arg  Cys Tyr Phe Tyr Gln  
    2840                 2845                 2850 


<210> 6189
<211> 291
<212> PRT
<213> Homo sapiens

<400> 6189
Met Ser Ser Gly Ala Asp Gly Gly Gly Gly Ala Ala Val Ala Ala Arg 
1               5                   10                  15      


Ser Asp Lys Gly Ser Pro Gly Glu Asp Gly Phe Val Pro Ser Ala Leu 
            20                  25                  30          


Gly Thr Arg Glu His Trp Asp Ala Val Tyr Glu Arg Glu Leu Gln Thr 
        35                  40                  45              


Phe Arg Glu Tyr Gly Asp Thr Gly Glu Ile Trp Phe Gly Glu Glu Ser 
    50                  55                  60                  


Met Asn Arg Leu Ile Arg Trp Met Gln Lys His Lys Ile Pro Leu Asp 
65                  70                  75                  80  


Ala Ser Val Leu Asp Ile Gly Thr Gly Asn Gly Val Phe Leu Val Glu 
                85                  90                  95      


Leu Ala Lys Phe Gly Phe Ser Asn Ile Thr Gly Ile Asp Tyr Ser Pro 
            100                 105                 110         


Ser Ala Ile Gln Leu Ser Gly Ser Ile Ile Glu Lys Glu Gly Leu Ser 
        115                 120                 125             


Asn Ile Lys Leu Lys Val Glu Asp Phe Leu Asn Leu Ser Thr Gln Leu 
    130                 135                 140                 


Ser Gly Phe His Ile Cys Ile Asp Lys Gly Thr Phe Asp Ala Ile Ser 
145                 150                 155                 160 


Leu Asn Pro Asp Asn Ala Ile Glu Lys Arg Lys Gln Tyr Val Lys Ser 
                165                 170                 175     


Leu Ser Arg Val Leu Lys Val Lys Gly Phe Phe Leu Ile Thr Ser Cys 
            180                 185                 190         


Asn Trp Thr Lys Glu Glu Leu Leu Asn Glu Phe Ser Glu Gly Trp Ser 
        195                 200                 205             


Thr Val Ala Gly Phe Trp Leu Thr Ala Ala Leu Thr Ser Trp Ala Gln 
    210                 215                 220                 


Ala Ile Phe Ser Thr Ser Ala Ser Arg Val Gly Gly Thr Thr Gly Thr 
225                 230                 235                 240 


His His His Ala Trp Ile Ile Phe Val Phe Leu Ala Glu Thr Arg Phe 
                245                 250                 255     


Cys His Val Val Gln Ala Gly Leu Glu Leu Leu Gly Ser Ser Asp Ser 
            260                 265                 270         


Pro Thr Trp Pro Pro Lys Val Leu Gly Leu Tyr His Ala Arg Pro Ser 
        275                 280                 285             


Leu Ala Phe 
    290     


<210> 6190
<211> 210
<212> PRT
<213> Homo sapiens

<400> 6190
Met Ala Pro Trp Gly Lys Arg Leu Ala Gly Val Arg Gly Val Leu Leu 
1               5                   10                  15      


Asp Ile Ser Gly Val Leu Tyr Asp Ser Gly Ala Gly Gly Gly Thr Ala 
            20                  25                  30          


Ile Ala Gly Ser Val Glu Ala Val Ala Arg Leu Lys Arg Ser Arg Leu 
        35                  40                  45              


Lys Val Arg Phe Cys Thr Asn Glu Ser Gln Lys Ser Arg Ala Glu Leu 
    50                  55                  60                  


Val Gly Gln Leu Gln Arg Leu Gly Phe Asp Ile Ser Glu Gln Glu Val 
65                  70                  75                  80  


Thr Ala Pro Ala Pro Ala Ala Cys Gln Ile Leu Lys Glu Gln Gly Leu 
                85                  90                  95      


Arg Pro Tyr Leu Leu Ile His Asp Gly Val Arg Ser Glu Phe Asp Gln 
            100                 105                 110         


Ile Asp Thr Ser Asn Pro Asn Cys Val Val Ile Ala Asp Ala Gly Glu 
        115                 120                 125             


Ser Phe Ser Tyr Gln Asn Met Asn Asn Ala Phe Gln Val Leu Met Glu 
    130                 135                 140                 


Leu Glu Lys Pro Val Leu Ile Ser Leu Gly Lys Gly Arg Tyr Tyr Lys 
145                 150                 155                 160 


Glu Thr Ser Gly Leu Met Leu Asp Val Gly Pro Tyr Met Lys Ala Leu 
                165                 170                 175     


Glu Tyr Ala Cys Gly Ile Lys Ala Glu Val Val Gly Lys Pro Ser Pro 
            180                 185                 190         


Glu Phe Phe Lys Ser Ala Leu Gln Ala Ile Gly Val Glu Ala His Gln 
        195                 200                 205             


Ala Gln 
    210 


<210> 6191
<211> 270
<212> PRT
<213> Homo sapiens

<400> 6191
Met Ala Pro Trp Gly Lys Arg Leu Ala Gly Val Arg Gly Val Leu Leu 
1               5                   10                  15      


Asp Ile Ser Gly Val Leu Tyr Asp Ser Gly Ala Gly Gly Gly Thr Ala 
            20                  25                  30          


Ile Ala Gly Ser Val Glu Ala Val Ala Arg Leu Lys Arg Ser Arg Leu 
        35                  40                  45              


Lys Val Arg Phe Cys Thr Asn Glu Ser Gln Lys Ser Arg Ala Glu Leu 
    50                  55                  60                  


Val Gly Gln Leu Gln Arg Leu Gly Phe Asp Ile Ser Glu Gln Glu Val 
65                  70                  75                  80  


Thr Ala Pro Ala Pro Ala Ala Cys Gln Ile Leu Lys Glu Gln Gly Leu 
                85                  90                  95      


Arg Pro Tyr Leu Leu Ile His Asp Gly Val Arg Ser Glu Phe Asp Gln 
            100                 105                 110         


Ile Asp Thr Ser Asn Pro Asn Cys Val Val Ile Ala Asp Ala Gly Glu 
        115                 120                 125             


Ser Phe Ser Tyr Gln Asn Met Asn Asn Ala Phe Gln Val Leu Met Glu 
    130                 135                 140                 


Leu Glu Lys Pro Val Leu Ile Ser Leu Gly Lys Gly Arg Tyr Tyr Lys 
145                 150                 155                 160 


Glu Thr Ser Gly Leu Met Leu Asp Val Gly Pro Tyr Met Lys Ala Leu 
                165                 170                 175     


Glu Tyr Ala Cys Gly Ile Lys Ala Glu Val Val Gly Lys Pro Ser Pro 
            180                 185                 190         


Glu Phe Phe Lys Ser Ala Leu Gln Ala Ile Gly Val Glu Ala His Gln 
        195                 200                 205             


Ala Val Met Ile Gly Asp Asp Ile Val Gly Asp Val Gly Gly Ala Gln 
    210                 215                 220                 


Arg Cys Gly Met Arg Ala Leu Gln Val Arg Thr Gly Lys Phe Arg Pro 
225                 230                 235                 240 


Ser Asp Glu His His Pro Glu Val Lys Ala Asp Gly Tyr Val Asp Asn 
                245                 250                 255     


Leu Ala Glu Ala Val Asp Leu Leu Leu Gln His Ala Asp Lys 
            260                 265                 270 


<210> 6192
<211> 1315
<212> PRT
<213> Homo sapiens

<400> 6192
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Pro 
                85                  90                  95      


Gly Thr Gln Phe Val Lys Pro Thr Val Gly Val Pro Gln Val Phe Ser 
            100                 105                 110         


Gln Met Thr Pro Val Arg Pro Gly Ser Thr Met Pro Val Arg Pro Thr 
        115                 120                 125             


Thr Asn Thr Phe Thr Thr Val Ile Pro Ala Thr Leu Thr Ile Arg Ser 
    130                 135                 140                 


Thr Val Pro Gln Ser Gln Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr 
145                 150                 155                 160 


Ser Thr Thr Pro Thr Ala Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala 
                165                 170                 175     


Val Gln Ser Pro Gly Gln Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala 
            180                 185                 190         


Pro Ser Phe Pro Ser Pro Pro Ala Val Ser Ile Ala Ser Phe Val Thr 
        195                 200                 205             


Val Lys Arg Pro Gly Val Thr Gly Glu Asn Ser Asn Glu Val Ala Lys 
    210                 215                 220                 


Leu Val Asn Thr Leu Asn Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly 
225                 230                 235                 240 


Pro Val Val Val Ser Asn Asn Ser Ser Ala His Gly Ser Gln Arg Thr 
                245                 250                 255     


Ser Gly Pro Glu Ser Ser Met Lys Val Thr Ser Ser Ile Pro Val Phe 
            260                 265                 270         


Asp Leu Gln Asp Gly Gly Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln 
        275                 280                 285             


Phe Arg Val Thr Glu Ala Leu Arg Gly His Met Cys Tyr Cys Cys Pro 
    290                 295                 300                 


Glu Met Val Glu Tyr Gln Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro 
305                 310                 315                 320 


Ser Val Pro Ser Ala Ala Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro 
                325                 330                 335     


Val Ala Ser Thr Pro Ser Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro 
            340                 345                 350         


Thr Lys Val Pro Glu Pro Asn Glu Asn Val Gly Asp Ala Val Gln Thr 
        355                 360                 365             


Lys Leu Ile Met Leu Val Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly 
    370                 375                 380                 


Lys Val Ala Gln Leu Thr Asn Phe Pro Lys Val Ala Thr Ser Phe Arg 
385                 390                 395                 400 


Cys Pro His Cys Thr Lys Arg Leu Lys Asn Asn Ile Arg Phe Met Asn 
                405                 410                 415     


His Met Lys His His Val Glu Leu Asp Gln Gln Asn Gly Glu Val Asp 
            420                 425                 430         


Gly His Thr Ile Cys Gln His Cys Tyr Arg Gln Phe Ser Thr Pro Phe 
        435                 440                 445             


Gln Leu Gln Cys His Leu Glu Asn Val His Ser Pro Tyr Glu Ser Thr 
    450                 455                 460                 


Thr Lys Cys Lys Ile Cys Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe 
465                 470                 475                 480 


Leu Gln His Met Lys Asp Thr His Lys Pro Gly Glu Met Pro Tyr Val 
                485                 490                 495     


Cys Gln Val Cys Gln Tyr Arg Ser Ser Leu Tyr Ser Glu Val Asp Val 
            500                 505                 510         


His Phe Arg Met Ile His Glu Asp Thr Arg His Leu Leu Cys Pro Tyr 
        515                 520                 525             


Cys Leu Lys Val Phe Lys Asn Gly Asn Ala Phe Gln Gln His Tyr Met 
    530                 535                 540                 


Arg His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys Arg Leu Gln 
545                 550                 555                 560 


Phe Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln His His Lys 
                565                 570                 575     


Thr Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro Gly Thr Lys 
            580                 585                 590         


Val Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val Pro Val Ser 
        595                 600                 605             


Ser Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala Pro Leu Thr 
    610                 615                 620                 


Ser Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro Val Gln Arg 
625                 630                 635                 640 


Ser Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met Gly Arg Gln 
                645                 650                 655     


Thr Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro Asn His Phe 
            660                 665                 670         


Pro Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr Cys Cys Ser 
        675                 680                 685             


Arg Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro Arg Lys Ser 
    690                 695                 700                 


Pro Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly Ile Lys Leu 
705                 710                 715                 720 


Ala Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp Ala Met Ala 
                725                 730                 735     


Lys His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser Ile Leu Pro 
            740                 745                 750         


Arg Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln Thr Arg Asp 
        755                 760                 765             


Arg Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro Pro Ser Phe 
    770                 775                 780                 


Pro Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala Thr Pro Ala 
785                 790                 795                 800 


Glu Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu Pro Ser Pro 
                805                 810                 815     


Ala Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro Gln Ala Leu 
            820                 825                 830         


Ala Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu Asn Val Asp 
        835                 840                 845             


Asp Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu Leu Ala Ser 
    850                 855                 860                 


Gly Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln Leu Ser Val 
865                 870                 875                 880 


Lys Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn Thr Glu Gln 
                885                 890                 895     


Ala Ala Glu His Phe Arg Asn Pro Gln Arg Arg Ile Arg Arg Trp Leu 
            900                 905                 910         


Arg Arg Phe Gln Ala Ser Gln Gly Glu Asn Leu Glu Gly Lys Tyr Leu 
        915                 920                 925             


Ser Phe Glu Ala Glu Glu Lys Leu Ala Glu Trp Val Leu Thr Gln Arg 
    930                 935                 940                 


Glu Gln Gln Leu Pro Val Asn Glu Glu Thr Leu Phe Gln Lys Ala Thr 
945                 950                 955                 960 


Lys Ile Gly Arg Ser Leu Glu Gly Gly Phe Lys Ile Ser Tyr Glu Trp 
                965                 970                 975     


Ala Val Arg Phe Met Leu Arg His His Leu Thr Pro His Ala Arg Arg 
            980                 985                 990         


Ala Val Ala His Thr Leu Pro Lys  Asp Val Ala Glu Asn  Ala Gly Leu 
        995                 1000                 1005             


Phe Ile  Asp Phe Val Gln Arg  Gln Ile His Asn Gln  Asp Leu Pro 
    1010                 1015                 1020             


Leu Ser  Met Ile Val Ala Ile  Asp Glu Ile Ser Leu  Phe Leu Asp 
    1025                 1030                 1035             


Thr Glu  Val Leu Ser Ser Asp  Asp Arg Lys Glu Asn  Ala Leu Gln 
    1040                 1045                 1050             


Thr Val  Gly Thr Gly Glu Pro  Trp Cys Asp Val Val  Leu Ala Ile 
    1055                 1060                 1065             


Leu Ala  Asp Gly Thr Val Leu  Pro Thr Leu Val Phe  Tyr Arg Gly 
    1070                 1075                 1080             


Gln Met  Asp Gln Pro Ala Asn  Met Pro Asp Ser Ile  Leu Leu Glu 
    1085                 1090                 1095             


Ala Lys  Glu Ser Gly Tyr Ser  Asp Asp Glu Ile Met  Glu Leu Trp 
    1100                 1105                 1110             


Ser Thr  Arg Val Trp Gln Lys  His Thr Ala Cys Gln  Arg Ser Lys 
    1115                 1120                 1125             


Gly Met  Leu Val Met Asp Cys  His Arg Thr His Leu  Ser Glu Glu 
    1130                 1135                 1140             


Val Leu  Ala Met Leu Ser Ala  Ser Ser Thr Leu Pro  Ala Val Val 
    1145                 1150                 1155             


Pro Ala  Gly Cys Ser Ser Lys  Ile Gln Pro Leu Asp  Val Cys Ile 
    1160                 1165                 1170             


Lys Arg  Thr Val Lys Asn Phe  Leu His Lys Lys Trp  Lys Glu Gln 
    1175                 1180                 1185             


Ala Arg  Glu Met Ala Asp Thr  Ala Cys Asp Ser Asp  Val Leu Leu 
    1190                 1195                 1200             


Gln Leu  Val Leu Val Trp Leu  Gly Glu Val Leu Gly  Val Ile Gly 
    1205                 1210                 1215             


Asp Cys  Pro Glu Leu Val Gln  Arg Ser Phe Leu Val  Ala Ser Val 
    1220                 1225                 1230             


Leu Pro  Gly Pro Asp Gly Asn  Ile Asn Ser Pro Thr  Arg Asn Ala 
    1235                 1240                 1245             


Asp Met  Gln Glu Glu Leu Ile  Ala Ser Leu Glu Glu  Gln Leu Lys 
    1250                 1255                 1260             


Leu Ser  Gly Glu His Ser Glu  Ser Ser Thr Pro Arg  Pro Arg Ser 
    1265                 1270                 1275             


Ser Pro  Glu Glu Thr Ile Glu  Pro Glu Ser Leu His  Gln Leu Phe 
    1280                 1285                 1290             


Glu Gly  Glu Ser Glu Thr Glu  Ser Phe Tyr Gly Phe  Glu Glu Ala 
    1295                 1300                 1305             


Asp Leu  Asp Leu Met Glu Ile  
    1310                 1315 


<210> 6193
<211> 801
<212> PRT
<213> Homo sapiens

<400> 6193
Met Gly Asp Thr Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu 
1               5                   10                  15      


Pro Thr Ser Gly Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
            20                  25                  30          


Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
        35                  40                  45              


Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
    50                  55                  60                  


Gly Val Ala Val Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly 
65                  70                  75                  80  


Asp Gly Val Asp Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln 
                85                  90                  95      


Ile Arg Glu Glu Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr 
            100                 105                 110         


Ala Lys Gly Ala Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
        115                 120                 125             


Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
    130                 135                 140                 


Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
145                 150                 155                 160 


Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                165                 170                 175     


Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
            180                 185                 190         


Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
        195                 200                 205             


Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
    210                 215                 220                 


Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
225                 230                 235                 240 


Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser 
                245                 250                 255     


Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
            260                 265                 270         


Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
        275                 280                 285             


Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Pro 
    290                 295                 300                 


Val Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile 
305                 310                 315                 320 


Gly Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg 
                325                 330                 335     


Leu Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val 
            340                 345                 350         


Trp Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His 
        355                 360                 365             


Thr Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile 
    370                 375                 380                 


Tyr Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro 
385                 390                 395                 400 


Ala Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn 
                405                 410                 415     


Leu Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser 
            420                 425                 430         


Thr Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp 
        435                 440                 445             


Ile Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys 
    450                 455                 460                 


Asp Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser 
465                 470                 475                 480 


Lys Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser 
                485                 490                 495     


Glu Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp 
            500                 505                 510         


Pro Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg 
        515                 520                 525             


Ile Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu 
    530                 535                 540                 


Ser Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala 
545                 550                 555                 560 


Phe Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val 
                565                 570                 575     


Pro Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser 
            580                 585                 590         


Gly Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys 
        595                 600                 605             


Lys Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly 
    610                 615                 620                 


Ser Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln 
625                 630                 635                 640 


Ser Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp 
                645                 650                 655     


Arg His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His 
            660                 665                 670         


Ile Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe 
        675                 680                 685             


Glu Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly 
    690                 695                 700                 


Gly Leu Asp Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln 
705                 710                 715                 720 


Gly Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val 
                725                 730                 735     


Glu Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser 
            740                 745                 750         


Thr Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu 
        755                 760                 765             


Gln Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser 
    770                 775                 780                 


Ile Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile 
785                 790                 795                 800 


Met 
    


<210> 6194
<211> 816
<212> PRT
<213> Homo sapiens

<400> 6194
Met Gly Asp Thr Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu 
1               5                   10                  15      


Pro Thr Ser Gly Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
            20                  25                  30          


Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
        35                  40                  45              


Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
    50                  55                  60                  


Gly Val Ala Val Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly 
65                  70                  75                  80  


Asp Gly Val Asp Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln 
                85                  90                  95      


Ile Arg Glu Glu Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr 
            100                 105                 110         


Ala Lys Gly Ala Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
        115                 120                 125             


Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
    130                 135                 140                 


Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
145                 150                 155                 160 


Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                165                 170                 175     


Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
            180                 185                 190         


Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
        195                 200                 205             


Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
    210                 215                 220                 


Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
225                 230                 235                 240 


Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser 
                245                 250                 255     


Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
            260                 265                 270         


Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
        275                 280                 285             


Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu 
    290                 295                 300                 


Leu Ser Ser Ser Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val 
305                 310                 315                 320 


Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly 
                325                 330                 335     


Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu 
            340                 345                 350         


Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp 
        355                 360                 365             


Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His Thr 
    370                 375                 380                 


Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr 
385                 390                 395                 400 


Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro Ala 
                405                 410                 415     


Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu 
            420                 425                 430         


Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr 
        435                 440                 445             


Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile 
    450                 455                 460                 


Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp 
465                 470                 475                 480 


Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys 
                485                 490                 495     


Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu 
            500                 505                 510         


Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro 
        515                 520                 525             


Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile 
    530                 535                 540                 


Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser 
545                 550                 555                 560 


Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe 
                565                 570                 575     


Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro 
            580                 585                 590         


Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly 
        595                 600                 605             


Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys 
    610                 615                 620                 


Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser 
625                 630                 635                 640 


Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser 
                645                 650                 655     


Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg 
            660                 665                 670         


His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile 
        675                 680                 685             


Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu 
    690                 695                 700                 


Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly 
705                 710                 715                 720 


Leu Asp Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly 
                725                 730                 735     


Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu 
            740                 745                 750         


Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr 
        755                 760                 765             


Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln 
    770                 775                 780                 


Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile 
785                 790                 795                 800 


Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
                805                 810                 815     


<210> 6195
<211> 801
<212> PRT
<213> Homo sapiens

<400> 6195
Met Gly Asp Thr Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu 
1               5                   10                  15      


Pro Thr Ser Gly Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
            20                  25                  30          


Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
        35                  40                  45              


Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
    50                  55                  60                  


Gly Val Ala Val Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly 
65                  70                  75                  80  


Asp Gly Val Asp Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln 
                85                  90                  95      


Ile Arg Glu Glu Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr 
            100                 105                 110         


Ala Lys Gly Ala Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
        115                 120                 125             


Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
    130                 135                 140                 


Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
145                 150                 155                 160 


Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                165                 170                 175     


Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
            180                 185                 190         


Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
        195                 200                 205             


Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
    210                 215                 220                 


Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
225                 230                 235                 240 


Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser 
                245                 250                 255     


Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
            260                 265                 270         


Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
        275                 280                 285             


Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Pro 
    290                 295                 300                 


Val Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile 
305                 310                 315                 320 


Gly Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg 
                325                 330                 335     


Leu Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val 
            340                 345                 350         


Trp Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His 
        355                 360                 365             


Thr Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile 
    370                 375                 380                 


Tyr Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro 
385                 390                 395                 400 


Ala Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn 
                405                 410                 415     


Leu Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser 
            420                 425                 430         


Thr Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp 
        435                 440                 445             


Ile Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys 
    450                 455                 460                 


Asp Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser 
465                 470                 475                 480 


Lys Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser 
                485                 490                 495     


Glu Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp 
            500                 505                 510         


Pro Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg 
        515                 520                 525             


Ile Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu 
    530                 535                 540                 


Ser Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala 
545                 550                 555                 560 


Phe Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val 
                565                 570                 575     


Pro Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser 
            580                 585                 590         


Gly Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys 
        595                 600                 605             


Lys Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly 
    610                 615                 620                 


Ser Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln 
625                 630                 635                 640 


Ser Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp 
                645                 650                 655     


Arg His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His 
            660                 665                 670         


Ile Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe 
        675                 680                 685             


Glu Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly 
    690                 695                 700                 


Gly Leu Asp Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln 
705                 710                 715                 720 


Gly Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val 
                725                 730                 735     


Glu Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser 
            740                 745                 750         


Thr Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu 
        755                 760                 765             


Gln Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser 
    770                 775                 780                 


Ile Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile 
785                 790                 795                 800 


Met 
    


<210> 6196
<211> 828
<212> PRT
<213> Homo sapiens

<400> 6196
Met Arg Phe Leu Glu Ala Arg Ser Leu Ala Val Ala Met Gly Asp Thr 
1               5                   10                  15      


Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu Pro Thr Ser Gly 
            20                  25                  30          


Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val Ile Thr Glu Gly 
        35                  40                  45              


Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala Gln Lys Ala Cys 
    50                  55                  60                  


Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly Gly Val Ala Val 
65                  70                  75                  80  


Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly Asp Gly Val Asp 
                85                  90                  95      


Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln Ile Arg Glu Glu 
            100                 105                 110         


Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr Ala Lys Gly Ala 
        115                 120                 125             


Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser Trp Leu Leu Arg 
    130                 135                 140                 


Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala Ile Ser Tyr Leu 
145                 150                 155                 160 


Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile Gly Asn Arg Leu 
                165                 170                 175     


Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu Pro Gln Leu Leu 
            180                 185                 190         


Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp Ala Ile Lys Pro 
        195                 200                 205             


Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe Ser Leu Gln Cys 
    210                 215                 220                 


Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His Ile Ser Thr Gln 
225                 230                 235                 240 


Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile Leu Ser Asp Glu 
                245                 250                 255     


Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser Leu Ser Pro Ala 
            260                 265                 270         


Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His Gln Arg Ser Lys 
        275                 280                 285             


Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn Leu Lys Arg Thr 
    290                 295                 300                 


Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu Leu Ser Ser Ser 
305                 310                 315                 320 


Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val Arg Leu Ala Pro 
                325                 330                 335     


Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly Lys Arg Leu Ala 
            340                 345                 350         


Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu Ile Ser Glu Leu 
        355                 360                 365             


Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp Leu Pro Thr Ala 
    370                 375                 380                 


Gly Phe Asp His His Val Val Arg Val Pro His Thr Gln Ala Val Val 
385                 390                 395                 400 


Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr Val Glu Val Leu 
                405                 410                 415     


Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro Ala Arg Ile Pro Glu 
            420                 425                 430         


Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu Pro Glu Cys Gly 
        435                 440                 445             


Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr Val Pro Asn Tyr 
    450                 455                 460                 


Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile Gly Glu Leu Gln 
465                 470                 475                 480 


Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp Asn Ile Ser Gln 
                485                 490                 495     


Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys Glu Pro Val Phe 
            500                 505                 510         


Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu Gln Leu Ala His 
        515                 520                 525             


Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro Ser Ala Val Ala 
    530                 535                 540                 


Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile Arg Glu Gly Ser 
545                 550                 555                 560 


Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser Val Ile Val Lys 
                565                 570                 575     


Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe Gln Val Leu Lys 
            580                 585                 590         


Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro Leu Trp Ile Lys 
        595                 600                 605             


Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly Met Ile Glu Pro 
    610                 615                 620                 


Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys Gln Ser Gln Leu 
625                 630                 635                 640 


Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser Tyr Thr Thr Glu 
                645                 650                 655     


Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser Cys Ala Gly Tyr 
            660                 665                 670         


Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg His Asn Gly Asn 
        675                 680                 685             


Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile Asp Phe Gly Phe 
    690                 695                 700                 


Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu Thr Ser Ala Phe 
705                 710                 715                 720 


Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly Leu Asp Gly Asp 
                725                 730                 735     


Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly Leu Ile Ala Ala 
            740                 745                 750         


Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu Ile Met Gln Gln 
        755                 760                 765             


Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr Ile Arg Asn Leu 
    770                 775                 780                 


Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln Leu Gln Leu Leu 
785                 790                 795                 800 


Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile Thr Thr Lys Leu 
                805                 810                 815     


Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
            820                 825             


<210> 6197
<211> 380
<212> PRT
<213> Homo sapiens

<400> 6197
Met Val Leu Glu Ser Thr Met Val Cys Val Asp Asn Ser Glu Tyr Met 
1               5                   10                  15      


Arg Asn Gly Asp Phe Leu Pro Thr Arg Leu Gln Ala Gln Gln Asp Ala 
            20                  25                  30          


Val Asn Ile Val Cys His Ser Lys Thr Arg Ser Asn Pro Glu Asn Asn 
        35                  40                  45              


Val Gly Leu Ile Thr Leu Ala Asn Asp Cys Glu Val Leu Thr Thr Leu 
    50                  55                  60                  


Thr Pro Asp Thr Gly Arg Ile Leu Ser Lys Leu His Thr Val Gln Pro 
65                  70                  75                  80  


Lys Gly Lys Ile Thr Phe Cys Thr Gly Ile Arg Val Ala His Leu Ala 
                85                  90                  95      


Leu Lys His Arg Gln Gly Lys Asn His Lys Met Arg Ile Ile Ala Phe 
            100                 105                 110         


Val Gly Ser Pro Val Glu Asp Asn Glu Lys Asp Leu Val Lys Leu Ala 
        115                 120                 125             


Lys Arg Leu Lys Lys Glu Lys Val Asn Val Asp Ile Ile Asn Phe Gly 
    130                 135                 140                 


Glu Glu Glu Val Asn Thr Glu Lys Leu Thr Ala Phe Val Asn Thr Leu 
145                 150                 155                 160 


Asn Gly Lys Asp Gly Thr Gly Ser His Leu Val Thr Val Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Ala Asp Ala Leu Ile Ser Ser Pro Ile Leu Ala Gly Glu 
            180                 185                 190         


Gly Gly Ala Met Leu Gly Leu Gly Ala Ser Asp Phe Glu Phe Gly Val 
        195                 200                 205             


Asp Pro Ser Ala Asp Pro Glu Leu Ala Leu Ala Leu Arg Val Ser Met 
    210                 215                 220                 


Glu Glu Gln Arg Gln Arg Gln Glu Glu Glu Ala Arg Arg Ala Ala Ala 
225                 230                 235                 240 


Ala Ser Ala Ala Glu Ala Gly Ile Ala Thr Thr Gly Thr Glu Gly Glu 
                245                 250                 255     


Arg Asp Ser Asp Asp Ala Leu Leu Lys Met Thr Ile Ser Gln Gln Glu 
            260                 265                 270         


Phe Gly Arg Thr Gly Leu Pro Asp Leu Ser Ser Met Thr Glu Glu Glu 
        275                 280                 285             


Gln Ile Ala Tyr Ala Met Gln Met Ser Leu Gln Gly Ala Glu Phe Gly 
    290                 295                 300                 


Gln Ala Glu Ser Ala Asp Ile Asp Ala Ser Ser Ala Met Asp Thr Ser 
305                 310                 315                 320 


Glu Pro Ala Lys Glu Glu Asp Asp Tyr Asp Val Met Gln Asp Pro Glu 
                325                 330                 335     


Phe Leu Gln Ser Val Leu Glu Asn Leu Pro Gly Val Asp Pro Asn Asn 
            340                 345                 350         


Glu Ala Ile Arg Asn Ala Met Gly Ser Leu Ala Ser Gln Ala Thr Lys 
        355                 360                 365             


Asp Gly Lys Lys Asp Lys Lys Glu Glu Asp Lys Lys 
    370                 375                 380 


<210> 6198
<211> 377
<212> PRT
<213> Homo sapiens

<400> 6198
Met Val Leu Glu Ser Thr Met Val Cys Val Asp Asn Ser Glu Tyr Met 
1               5                   10                  15      


Arg Asn Gly Asp Phe Leu Pro Thr Arg Leu Gln Ala Gln Gln Asp Ala 
            20                  25                  30          


Val Asn Ile Val Cys His Ser Lys Thr Arg Ser Asn Pro Glu Asn Asn 
        35                  40                  45              


Val Gly Leu Ile Thr Leu Ala Asn Asp Cys Glu Val Leu Thr Thr Leu 
    50                  55                  60                  


Thr Pro Asp Thr Gly Arg Ile Leu Ser Lys Leu His Thr Val Gln Pro 
65                  70                  75                  80  


Lys Gly Lys Ile Thr Phe Cys Thr Gly Ile Arg Val Ala His Leu Ala 
                85                  90                  95      


Leu Lys His Arg Gln Gly Lys Asn His Lys Met Arg Ile Ile Ala Phe 
            100                 105                 110         


Val Gly Ser Pro Val Glu Asp Asn Glu Lys Asp Leu Val Lys Leu Ala 
        115                 120                 125             


Lys Arg Leu Lys Lys Glu Lys Val Asn Val Asp Ile Ile Asn Phe Gly 
    130                 135                 140                 


Glu Glu Glu Val Asn Thr Glu Lys Leu Thr Ala Phe Val Asn Thr Leu 
145                 150                 155                 160 


Asn Gly Lys Asp Gly Thr Gly Ser His Leu Val Thr Val Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Ala Asp Ala Leu Ile Ser Ser Pro Ile Leu Ala Gly Glu 
            180                 185                 190         


Gly Gly Ala Met Leu Gly Leu Gly Ala Ser Asp Phe Glu Phe Gly Val 
        195                 200                 205             


Asp Pro Ser Ala Asp Pro Glu Leu Ala Leu Ala Leu Arg Val Ser Met 
    210                 215                 220                 


Glu Glu Gln Arg Gln Arg Gln Glu Glu Glu Ala Arg Arg Ala Ala Ala 
225                 230                 235                 240 


Ala Ser Ala Ala Glu Ala Gly Ile Ala Thr Thr Gly Thr Glu Asp Ser 
                245                 250                 255     


Asp Asp Ala Leu Leu Lys Met Thr Ile Ser Gln Gln Glu Phe Gly Arg 
            260                 265                 270         


Thr Gly Leu Pro Asp Leu Ser Ser Met Thr Glu Glu Glu Gln Ile Ala 
        275                 280                 285             


Tyr Ala Met Gln Met Ser Leu Gln Gly Ala Glu Phe Gly Gln Ala Glu 
    290                 295                 300                 


Ser Ala Asp Ile Asp Ala Ser Ser Ala Met Asp Thr Ser Glu Pro Ala 
305                 310                 315                 320 


Lys Glu Glu Asp Asp Tyr Asp Val Met Gln Asp Pro Glu Phe Leu Gln 
                325                 330                 335     


Ser Val Leu Glu Asn Leu Pro Gly Val Asp Pro Asn Asn Glu Ala Ile 
            340                 345                 350         


Arg Asn Ala Met Gly Ser Leu Ala Ser Gln Ala Thr Lys Asp Gly Lys 
        355                 360                 365             


Lys Asp Lys Lys Glu Glu Asp Lys Lys 
    370                 375         


<210> 6199
<211> 310
<212> PRT
<213> Homo sapiens

<400> 6199
Met Arg Pro Ala Arg His Trp Glu Thr Arg Phe Gly Ala Arg Asp Phe 
1               5                   10                  15      


Gly Gly Phe Gln Asp Cys Phe Phe Arg Asp Arg Leu Met Asp Thr Ala 
            20                  25                  30          


Arg Ile Ala Val Val Gly Ala Gly Val Val Gly Leu Ser Thr Ala Val 
        35                  40                  45              


Cys Ile Ser Lys Leu Val Pro Arg Cys Ser Val Thr Ile Ile Ser Asp 
    50                  55                  60                  


Lys Phe Thr Pro Asp Thr Thr Ser Asp Val Ala Ala Gly Met Leu Ile 
65                  70                  75                  80  


Pro His Thr Tyr Pro Asp Thr Pro Ile His Thr Gln Lys Gln Trp Phe 
                85                  90                  95      


Arg Glu Thr Phe Asn His Leu Phe Ala Ile Ala Asn Ser Ala Glu Ala 
            100                 105                 110         


Gly Asp Ala Gly Val His Leu Val Ser Gly Ile Lys Gly Ser Gly Gly 
        115                 120                 125             


Trp Thr Leu Thr Arg Arg Ile Glu Asp Leu Trp Glu Leu His Pro Ser 
    130                 135                 140                 


Phe Asp Ile Val Val Asn Cys Ser Gly Leu Gly Ser Arg Gln Leu Ala 
145                 150                 155                 160 


Gly Asp Ser Lys Ile Phe Pro Val Arg Gly Gln Val Leu Gln Val Gln 
                165                 170                 175     


Ala Pro Trp Val Glu His Phe Ile Arg Asp Gly Ser Gly Leu Thr Tyr 
            180                 185                 190         


Ile Tyr Pro Gly Thr Ser His Val Thr Leu Gly Gly Thr Arg Gln Lys 
        195                 200                 205             


Gly Asp Trp Asn Leu Ser Pro Asp Ala Glu Asn Ser Arg Glu Ile Leu 
    210                 215                 220                 


Ser Arg Cys Cys Ala Leu Glu Pro Ser Leu His Gly Ala Cys Asn Ile 
225                 230                 235                 240 


Arg Glu Lys Val Gly Leu Arg Pro Tyr Arg Pro Gly Val Arg Leu Gln 
                245                 250                 255     


Thr Glu Leu Leu Ala Arg Asp Gly Gln Arg Leu Pro Val Val His His 
            260                 265                 270         


Tyr Gly His Gly Ser Gly Gly Ile Ser Val His Trp Gly Thr Ala Leu 
        275                 280                 285             


Glu Ala Ala Arg Leu Val Ser Glu Cys Val His Ala Leu Arg Thr Pro 
    290                 295                 300                 


Ile Pro Lys Ser Asn Leu 
305                 310 


<210> 6200
<211> 369
<212> PRT
<213> Homo sapiens

<400> 6200
Met Arg Pro Ala Arg His Trp Glu Thr Arg Phe Gly Ala Arg Asp Phe 
1               5                   10                  15      


Gly Gly Phe Gln Asp Cys Phe Phe Arg Asp Arg Leu Met Asp Thr Ala 
            20                  25                  30          


Arg Ile Ala Val Val Gly Ala Gly Val Val Gly Leu Ser Thr Ala Val 
        35                  40                  45              


Cys Ile Ser Lys Leu Val Pro Arg Cys Ser Val Thr Ile Ile Ser Asp 
    50                  55                  60                  


Lys Phe Thr Pro Asp Thr Thr Ser Asp Val Ala Ala Gly Met Leu Ile 
65                  70                  75                  80  


Pro His Thr Tyr Pro Asp Thr Pro Ile His Thr Gln Lys Gln Trp Phe 
                85                  90                  95      


Arg Glu Thr Phe Asn His Leu Phe Ala Ile Ala Asn Ser Ala Glu Ala 
            100                 105                 110         


Gly Asp Ala Gly Val His Leu Val Ser Gly Trp Gln Ile Phe Gln Ser 
        115                 120                 125             


Thr Pro Thr Glu Glu Val Pro Phe Trp Ala Asp Val Val Leu Gly Phe 
    130                 135                 140                 


Arg Lys Met Thr Glu Ala Glu Leu Lys Lys Phe Pro Gln Tyr Val Phe 
145                 150                 155                 160 


Gly Gln Ala Phe Thr Thr Leu Lys Cys Glu Cys Pro Ala Tyr Leu Pro 
                165                 170                 175     


Trp Leu Glu Lys Arg Ile Lys Gly Ser Gly Gly Trp Thr Leu Thr Arg 
            180                 185                 190         


Arg Ile Glu Asp Leu Trp Glu Leu His Pro Ser Phe Asp Ile Val Val 
        195                 200                 205             


Asn Cys Ser Gly Leu Gly Ser Arg Gln Leu Ala Gly Asp Ser Lys Ile 
    210                 215                 220                 


Phe Pro Val Arg Gly Gln Val Leu Gln Val Gln Ala Pro Trp Val Glu 
225                 230                 235                 240 


His Phe Ile Arg Asp Gly Ser Gly Leu Thr Tyr Ile Tyr Pro Gly Thr 
                245                 250                 255     


Ser His Val Thr Leu Gly Gly Thr Arg Gln Lys Gly Asp Trp Asn Leu 
            260                 265                 270         


Ser Pro Asp Ala Glu Asn Ser Arg Glu Ile Leu Ser Arg Cys Cys Ala 
        275                 280                 285             


Leu Glu Pro Ser Leu His Gly Ala Cys Asn Ile Arg Glu Lys Val Gly 
    290                 295                 300                 


Leu Arg Pro Tyr Arg Pro Gly Val Arg Leu Gln Thr Glu Leu Leu Ala 
305                 310                 315                 320 


Arg Asp Gly Gln Arg Leu Pro Val Val His His Tyr Gly His Gly Ser 
                325                 330                 335     


Gly Gly Ile Ser Val His Trp Gly Thr Ala Leu Glu Ala Ala Arg Leu 
            340                 345                 350         


Val Ser Glu Cys Val His Ala Leu Arg Thr Pro Ile Pro Lys Ser Asn 
        355                 360                 365             


Leu 
    


<210> 6201
<211> 341
<212> PRT
<213> Homo sapiens

<400> 6201
Met Asp Thr Ala Arg Ile Ala Val Val Gly Ala Gly Val Val Gly Leu 
1               5                   10                  15      


Ser Thr Ala Val Cys Ile Ser Lys Leu Val Pro Arg Cys Ser Val Thr 
            20                  25                  30          


Ile Ile Ser Asp Lys Phe Thr Pro Asp Thr Thr Ser Asp Val Ala Ala 
        35                  40                  45              


Gly Met Leu Ile Pro His Thr Tyr Pro Asp Thr Pro Ile His Thr Gln 
    50                  55                  60                  


Lys Gln Trp Phe Arg Glu Thr Phe Asn His Leu Phe Ala Ile Ala Asn 
65                  70                  75                  80  


Ser Ala Glu Ala Gly Asp Ala Gly Val His Leu Val Ser Gly Trp Gln 
                85                  90                  95      


Ile Phe Gln Ser Thr Pro Thr Glu Glu Val Pro Phe Trp Ala Asp Val 
            100                 105                 110         


Val Leu Gly Phe Arg Lys Met Thr Glu Ala Glu Leu Lys Lys Phe Pro 
        115                 120                 125             


Gln Tyr Val Phe Gly Gln Ala Phe Thr Thr Leu Lys Cys Glu Cys Pro 
    130                 135                 140                 


Ala Tyr Leu Pro Trp Leu Glu Lys Arg Ile Lys Gly Ser Gly Gly Trp 
145                 150                 155                 160 


Thr Leu Thr Arg Arg Ile Glu Asp Leu Trp Glu Leu His Pro Ser Phe 
                165                 170                 175     


Asp Ile Val Val Asn Cys Ser Gly Leu Gly Ser Arg Gln Leu Ala Gly 
            180                 185                 190         


Asp Ser Lys Ile Phe Pro Val Arg Gly Gln Val Leu Gln Val Gln Ala 
        195                 200                 205             


Pro Trp Val Glu His Phe Ile Arg Asp Gly Ser Gly Leu Thr Tyr Ile 
    210                 215                 220                 


Tyr Pro Gly Thr Ser His Val Thr Leu Gly Gly Thr Arg Gln Lys Gly 
225                 230                 235                 240 


Asp Trp Asn Leu Ser Pro Asp Ala Glu Asn Ser Arg Glu Ile Leu Ser 
                245                 250                 255     


Arg Cys Cys Ala Leu Glu Pro Ser Leu His Gly Ala Cys Asn Ile Arg 
            260                 265                 270         


Glu Lys Val Gly Leu Arg Pro Tyr Arg Pro Gly Val Arg Leu Gln Thr 
        275                 280                 285             


Glu Leu Leu Ala Arg Asp Gly Gln Arg Leu Pro Val Val His His Tyr 
    290                 295                 300                 


Gly His Gly Ser Gly Gly Ile Ser Val His Trp Gly Thr Ala Leu Glu 
305                 310                 315                 320 


Ala Ala Arg Leu Val Ser Glu Cys Val His Ala Leu Arg Thr Pro Ile 
                325                 330                 335     


Pro Lys Ser Asn Leu 
            340     


<210> 6202
<211> 357
<212> PRT
<213> Homo sapiens

<400> 6202
Met Gly Thr Ile Gln Glu Ala Gly Lys Lys Thr Asp Val Gly Val Arg 
1               5                   10                  15      


Glu Ile Ala Glu Ala Pro Glu Leu Gly Ala Ala Leu Arg His Gly Glu 
            20                  25                  30          


Leu Glu Leu Lys Glu Glu Trp Gln Asp Glu Glu Phe Pro Arg Leu Leu 
        35                  40                  45              


Pro Glu Glu Ala Gly Thr Ser Glu Asp Pro Glu Asp Pro Lys Gly Asp 
    50                  55                  60                  


Ser Gln Ala Ala Ala Gly Thr Pro Ser Thr Leu Ala Leu Cys Gly Gln 
65                  70                  75                  80  


Arg Pro Met Arg Lys Arg Leu Ser Ala Pro Glu Leu Arg Leu Ser Leu 
                85                  90                  95      


Thr Lys Gly Pro Gly Asn Asp Gly Ala Ser Pro Thr Gln Ser Ala Pro 
            100                 105                 110         


Ser Ser Pro Asp Gly Ser Ser Asp Leu Glu Ile Asp Glu Leu Glu Thr 
        115                 120                 125             


Pro Ser Asp Ser Glu Gln Leu Asp Ser Gly His Glu Phe Glu Trp Glu 
    130                 135                 140                 


Asp Glu Leu Pro Arg Ala Glu Gly Leu Gly Thr Ser Glu Thr Ala Glu 
145                 150                 155                 160 


Arg Leu Gly Arg Gly Cys Met Trp Asp Val Thr Gly Glu Asp Gly His 
                165                 170                 175     


His Trp Arg Val Phe Arg Met Gly Pro Arg Glu Gln Arg Val Asp Met 
            180                 185                 190         


Thr Val Ile Glu Pro Tyr Lys Lys Val Leu Ser His Gly Gly Tyr His 
        195                 200                 205             


Gly Asp Gly Leu Asn Ala Val Ile Leu Phe Ala Ser Cys Tyr Leu Pro 
    210                 215                 220                 


Arg Ser Ser Ile Pro Asn Tyr Thr Tyr Val Met Glu His Leu Phe Arg 
225                 230                 235                 240 


Tyr Met Val Gly Thr Leu Glu Leu Leu Val Ala Glu Asn Tyr Leu Leu 
                245                 250                 255     


Val His Leu Ser Gly Gly Thr Ser Arg Ala Gln Val Pro Pro Leu Ser 
            260                 265                 270         


Trp Ile Arg Gln Cys Tyr Arg Thr Leu Asp Arg Arg Leu Arg Lys Asn 
        275                 280                 285             


Leu Arg Ala Leu Val Val Val His Ala Thr Trp Tyr Val Lys Ala Phe 
    290                 295                 300                 


Leu Ala Leu Leu Arg Pro Phe Ile Ser Ser Lys Phe Thr Arg Lys Ile 
305                 310                 315                 320 


Arg Phe Leu Asp Ser Leu Gly Glu Leu Ala Gln Leu Ile Ser Leu Asp 
                325                 330                 335     


Gln Val His Ile Pro Glu Ala Val Arg Gln Leu Asp Arg Asp Leu His 
            340                 345                 350         


Gly Ser Gly Gly Thr 
        355         


<210> 6203
<211> 422
<212> PRT
<213> Homo sapiens

<400> 6203
Met Leu Lys Phe Leu Ala Lys Gly Glu Val Pro Lys Gly Ser Cys Glu 
1               5                   10                  15      


Asp Glu Pro Met Asp Ser Thr Met Asp Asp Ala Val Ala Gly Asp Phe 
            20                  25                  30          


Ala Leu Ile Asn Lys Leu Asp Ile Gln Cys Asp Leu Lys Thr Leu Ser 
        35                  40                  45              


Asp Asp Ile Lys Glu Ser Leu Glu Ser Glu Gly Lys Asn Ser Lys Lys 
    50                  55                  60                  


Glu Glu Pro Gln Glu Leu Leu Gln Ser Gln Asp Phe Val Gly Glu Lys 
65                  70                  75                  80  


Leu Gly Ser Gly Glu Pro Ser His Ser Val Lys Val His Thr Val Pro 
                85                  90                  95      


Lys Pro Gly Lys Gly Ala Asp Leu Ser Lys Pro Pro Cys Arg Lys Ala 
            100                 105                 110         


Lys Glu Ile Arg Lys Glu Arg Lys Arg Leu Lys Leu Met Gln Gln Asn 
        115                 120                 125             


Pro Ala Gly Glu Leu Glu Gly Phe Gln Ala Gln Gly His Pro Pro Ser 
    130                 135                 140                 


Leu Phe Pro Pro Lys Ala Lys Ser Asn Gln Pro Lys Ser Leu Glu Asp 
145                 150                 155                 160 


Leu Ile Phe Glu Ser Leu Pro Glu Asn Ala Ser His Lys Leu Glu Val 
                165                 170                 175     


Arg Leu Val Pro Val Ser Phe Glu Asp Pro Glu Phe Lys Ser Ser Phe 
            180                 185                 190         


Ser Gln Ser Phe Ser Leu Tyr Val Lys Tyr Gln Val Ala Ile His Gln 
        195                 200                 205             


Asp Pro Pro Asp Glu Cys Gly Lys Thr Glu Phe Thr Arg Phe Leu Cys 
    210                 215                 220                 


Ser Ser Pro Leu Glu Ala Glu Thr Pro Pro Asn Gly Pro Asp Cys Gly 
225                 230                 235                 240 


Tyr Gly Ser Phe His Gln Gln Tyr Trp Leu Asp Gly Lys Ile Ile Ala 
                245                 250                 255     


Val Gly Val Ile Asp Ile Leu Pro Asn Cys Val Ser Ser Val Tyr Leu 
            260                 265                 270         


Tyr Tyr Asp Pro Asp Tyr Ser Phe Leu Ser Leu Gly Val Tyr Ser Ala 
        275                 280                 285             


Leu Arg Glu Ile Ala Phe Thr Arg Gln Leu His Glu Lys Thr Ser Gln 
    290                 295                 300                 


Leu Ser Tyr Tyr Tyr Met Gly Phe Tyr Ile His Ser Cys Pro Lys Met 
305                 310                 315                 320 


Lys Tyr Lys Gly Gln Tyr Arg Pro Ser Asp Leu Leu Cys Pro Glu Thr 
                325                 330                 335     


Tyr Val Trp Val Pro Ile Glu Gln Cys Leu Pro Ser Leu Glu Asn Ser 
            340                 345                 350         


Lys Tyr Cys Arg Phe Asn Gln Asp Pro Glu Ala Val Asp Glu Asp Arg 
        355                 360                 365             


Ser Thr Glu Pro Asp Arg Leu Gln Val Phe His Lys Arg Ala Ile Met 
    370                 375                 380                 


Pro Tyr Gly Val Tyr Lys Lys Gln Gln Lys Asp Pro Ser Glu Glu Ala 
385                 390                 395                 400 


Ala Val Leu Gln Tyr Ala Ser Leu Val Gly Gln Lys Cys Ser Glu Arg 
                405                 410                 415     


Met Leu Leu Phe Arg Asn 
            420         


<210> 6204
<211> 518
<212> PRT
<213> Homo sapiens

<400> 6204
Met Ala Phe Trp Ala Gly Gly Ser Pro Ser Val Val Asp Tyr Phe Pro 
1               5                   10                  15      


Ser Glu Asp Phe Tyr Arg Cys Gly Tyr Cys Lys Asn Glu Ser Gly Ser 
            20                  25                  30          


Arg Ser Asn Gly Met Trp Ala His Ser Met Thr Val Gln Asp Tyr Gln 
        35                  40                  45              


Asp Leu Ile Asp Arg Gly Trp Arg Arg Ser Gly Lys Tyr Val Tyr Lys 
    50                  55                  60                  


Pro Val Met Asn Gln Thr Cys Cys Pro Gln Tyr Thr Ile Arg Cys Arg 
65                  70                  75                  80  


Pro Leu Gln Phe Gln Pro Ser Lys Ser His Lys Lys Val Leu Lys Lys 
                85                  90                  95      


Met Leu Lys Phe Leu Ala Lys Gly Glu Val Pro Lys Gly Ser Cys Glu 
            100                 105                 110         


Asp Glu Pro Met Asp Ser Thr Met Asp Asp Ala Val Ala Gly Asp Phe 
        115                 120                 125             


Ala Leu Ile Asn Lys Leu Asp Ile Gln Cys Asp Leu Lys Thr Leu Ser 
    130                 135                 140                 


Asp Asp Ile Lys Glu Ser Leu Glu Ser Glu Gly Lys Asn Ser Lys Lys 
145                 150                 155                 160 


Glu Glu Pro Gln Glu Leu Leu Gln Ser Gln Asp Phe Val Gly Glu Lys 
                165                 170                 175     


Leu Gly Ser Gly Glu Pro Ser His Ser Val Lys Val His Thr Val Pro 
            180                 185                 190         


Lys Pro Gly Lys Gly Ala Asp Leu Ser Lys Pro Pro Cys Arg Lys Ala 
        195                 200                 205             


Lys Glu Ile Arg Lys Glu Arg Lys Arg Leu Lys Leu Met Gln Gln Asn 
    210                 215                 220                 


Pro Ala Gly Glu Leu Glu Gly Phe Gln Ala Gln Gly His Pro Pro Ser 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Ala Lys Ser Asn Gln Pro Lys Ser Leu Glu Asp 
                245                 250                 255     


Leu Ile Phe Glu Ser Leu Pro Glu Asn Ala Ser His Lys Leu Glu Val 
            260                 265                 270         


Arg Leu Val Pro Val Ser Phe Glu Asp Pro Glu Phe Lys Ser Ser Phe 
        275                 280                 285             


Ser Gln Ser Phe Ser Leu Tyr Val Lys Tyr Gln Val Ala Ile His Gln 
    290                 295                 300                 


Asp Pro Pro Asp Glu Cys Gly Lys Thr Glu Phe Thr Arg Phe Leu Cys 
305                 310                 315                 320 


Ser Ser Pro Leu Glu Ala Glu Thr Pro Pro Asn Gly Pro Asp Cys Gly 
                325                 330                 335     


Tyr Gly Ser Phe His Gln Gln Tyr Trp Leu Asp Gly Lys Ile Ile Ala 
            340                 345                 350         


Val Gly Val Ile Asp Ile Leu Pro Asn Cys Val Ser Ser Val Tyr Leu 
        355                 360                 365             


Tyr Tyr Asp Pro Asp Tyr Ser Phe Leu Ser Leu Gly Val Tyr Ser Ala 
    370                 375                 380                 


Leu Arg Glu Ile Ala Phe Thr Arg Gln Leu His Glu Lys Thr Ser Gln 
385                 390                 395                 400 


Leu Ser Tyr Tyr Tyr Met Gly Phe Tyr Ile His Ser Cys Pro Lys Met 
                405                 410                 415     


Lys Tyr Lys Gly Gln Tyr Arg Pro Ser Asp Leu Leu Cys Pro Glu Thr 
            420                 425                 430         


Tyr Val Trp Val Pro Ile Glu Gln Cys Leu Pro Ser Leu Glu Asn Ser 
        435                 440                 445             


Lys Tyr Cys Arg Phe Asn Gln Asp Pro Glu Ala Val Asp Glu Asp Arg 
    450                 455                 460                 


Ser Thr Glu Pro Asp Arg Leu Gln Val Phe His Lys Arg Ala Ile Met 
465                 470                 475                 480 


Pro Tyr Gly Val Tyr Lys Lys Gln Gln Lys Asp Pro Ser Glu Glu Ala 
                485                 490                 495     


Ala Val Leu Gln Tyr Ala Ser Leu Val Gly Gln Lys Cys Ser Glu Arg 
            500                 505                 510         


Met Leu Leu Phe Arg Asn 
        515             


<210> 6205
<211> 1000
<212> PRT
<213> Homo sapiens

<400> 6205
Met Ala Glu Arg Lys Pro Asn Gly Gly Ser Gly Gly Ala Ser Thr Ser 
1               5                   10                  15      


Ser Ser Gly Thr Asn Leu Leu Phe Ser Ser Ser Ala Thr Glu Phe Ser 
            20                  25                  30          


Phe Asn Val Pro Phe Ile Pro Val Thr Gln Ala Ser Ala Ser Pro Ala 
        35                  40                  45              


Ser Leu Leu Leu Pro Gly Glu Asp Ser Thr Asp Val Gly Glu Glu Asp 
    50                  55                  60                  


Ser Phe Leu Gly Gln Thr Ser Ile His Thr Ser Ala Pro Gln Thr Phe 
65                  70                  75                  80  


Ser Tyr Phe Ser Gln Val Ser Ser Ser Ser Asp Pro Phe Gly Asn Ile 
                85                  90                  95      


Gly Gln Ser Pro Leu Thr Thr Ala Ala Thr Ser Val Gly Gln Ser Gly 
            100                 105                 110         


Phe Pro Lys Pro Leu Thr Ala Leu Pro Phe Thr Thr Gly Ser Gln Asp 
        115                 120                 125             


Val Ser Asn Ala Phe Ser Pro Ser Ile Ser Lys Ala Gln Pro Gly Ala 
    130                 135                 140                 


Pro Pro Ser Ser Leu Met Gly Ile Asn Ser Tyr Leu Pro Ser Gln Pro 
145                 150                 155                 160 


Ser Ser Leu Pro Pro Ser Tyr Phe Gly Asn Gln Pro Gln Gly Ile Pro 
                165                 170                 175     


Gln Pro Gly Tyr Asn Pro Tyr Arg His Thr Pro Gly Ser Ser Arg Ala 
            180                 185                 190         


Asn Pro Tyr Ile Ala Pro Pro Gln Leu Gln Gln Cys Gln Thr Pro Gly 
        195                 200                 205             


Pro Pro Ala His Pro Pro Pro Ser Gly Pro Pro Val Gln Met Tyr Gln 
    210                 215                 220                 


Met Pro Pro Gly Ser Leu Pro Pro Val Pro Ser Ser Val Gln Ser Pro 
225                 230                 235                 240 


Ala Gln Gln Gln Val Pro Ala Arg Pro Gly Ala Pro Ser Val Gln Val 
                245                 250                 255     


Pro Ser Pro Phe Leu Leu Gln Asn Gln Tyr Glu Pro Val Gln Pro His 
            260                 265                 270         


Trp Phe Tyr Cys Lys Glu Val Glu Tyr Lys Gln Leu Trp Met Pro Phe 
        275                 280                 285             


Ser Val Phe Asp Ser Leu Asn Leu Glu Glu Ile Tyr Asn Ser Val Gln 
    290                 295                 300                 


Pro Asp Pro Glu Ser Val Val Leu Gly Thr Asp Gly Gly Arg Tyr Asp 
305                 310                 315                 320 


Val Tyr Leu Tyr Asp Arg Ile Arg Lys Ala Ala Tyr Trp Glu Glu Glu 
                325                 330                 335     


Pro Ala Glu Val Arg Arg Cys Thr Trp Phe Tyr Lys Gly Asp Thr Asp 
            340                 345                 350         


Ser Arg Phe Ile Pro Tyr Thr Glu Glu Phe Ser Glu Lys Leu Glu Ala 
        355                 360                 365             


Glu Tyr Lys Lys Ala Val Thr Thr Asn Gln Trp His Arg Arg Leu Glu 
    370                 375                 380                 


Phe Pro Ser Gly Glu Thr Ile Val Met His Asn Pro Lys Val Ile Val 
385                 390                 395                 400 


Gln Phe Gln Pro Ser Ser Val Pro Asp Glu Trp Gly Thr Thr Gln Asp 
                405                 410                 415     


Gly Gln Thr Arg Pro Arg Val Val Lys Arg Gly Ile Asp Asp Asn Leu 
            420                 425                 430         


Asp Glu Ile Pro Asp Gly Glu Met Pro Gln Val Asp His Leu Val Phe 
        435                 440                 445             


Val Val His Gly Ile Gly Pro Val Cys Asp Leu Arg Phe Arg Ser Ile 
    450                 455                 460                 


Ile Glu Cys Val Asp Asp Phe Arg Val Val Ser Leu Lys Leu Leu Arg 
465                 470                 475                 480 


Thr His Phe Lys Lys Ser Leu Asp Asp Gly Lys Val Ser Arg Val Glu 
                485                 490                 495     


Phe Leu Pro Val His Trp His Ser Ser Leu Gly Gly Asp Ala Thr Gly 
            500                 505                 510         


Val Asp Arg Asn Ile Lys Lys Ile Thr Leu Pro Ser Ile Gly Arg Phe 
        515                 520                 525             


Arg His Phe Thr Asn Glu Thr Leu Leu Asp Ile Leu Phe Tyr Asn Ser 
    530                 535                 540                 


Pro Thr Tyr Cys Gln Thr Ile Val Glu Lys Val Gly Met Glu Ile Asn 
545                 550                 555                 560 


His Leu His Ala Leu Phe Met Ser Arg Asn Pro Asp Phe Lys Gly Gly 
                565                 570                 575     


Val Ser Val Ala Gly His Ser Leu Gly Ser Leu Ile Leu Phe Asp Ile 
            580                 585                 590         


Leu Ser Asn Gln Lys Asp Leu Asn Leu Ser Lys Cys Pro Gly Pro Leu 
        595                 600                 605             


Ala Val Ala Asn Gly Val Val Lys Gln Leu His Phe Gln Glu Lys Gln 
    610                 615                 620                 


Met Pro Glu Glu Pro Lys Leu Thr Leu Asp Glu Ser Tyr Asp Leu Val 
625                 630                 635                 640 


Val Glu Asn Lys Glu Val Leu Thr Leu Gln Glu Thr Leu Glu Ala Leu 
                645                 650                 655     


Ser Leu Ser Glu Tyr Phe Ser Thr Phe Glu Lys Glu Lys Ile Asp Met 
            660                 665                 670         


Glu Ser Leu Leu Met Cys Thr Val Asp Asp Leu Lys Glu Met Gly Ile 
        675                 680                 685             


Pro Leu Gly Pro Arg Lys Lys Ile Ala Asn Phe Val Glu His Lys Ala 
    690                 695                 700                 


Ala Lys Leu Lys Lys Ala Ala Ser Glu Lys Lys Ala Val Ala Ala Thr 
705                 710                 715                 720 


Ser Thr Lys Gly Gln Glu Gln Ser Ala Gln Lys Thr Lys Asp Met Ala 
                725                 730                 735     


Ser Leu Pro Ser Glu Ser Asn Glu Pro Lys Arg Lys Leu Pro Val Gly 
            740                 745                 750         


Ala Cys Val Ser Ser Val Cys Val Asn Tyr Glu Ser Phe Glu Val Gly 
        755                 760                 765             


Ala Gly Gln Val Ser Val Ala Tyr Asn Ser Leu Asp Phe Glu Pro Glu 
    770                 775                 780                 


Ile Phe Phe Ala Leu Gly Ser Pro Ile Ala Met Phe Leu Thr Ile Arg 
785                 790                 795                 800 


Gly Val Asp Arg Ile Asp Glu Asn Tyr Ser Leu Pro Thr Cys Lys Gly 
                805                 810                 815     


Phe Phe Asn Ile Tyr His Pro Leu Asp Pro Val Ala Tyr Arg Leu Glu 
            820                 825                 830         


Pro Met Ile Val Pro Asp Leu Asp Leu Lys Ala Val Leu Ile Pro His 
        835                 840                 845             


His Lys Gly Arg Lys Arg Leu His Leu Glu Leu Lys Glu Ser Leu Ser 
    850                 855                 860                 


Arg Met Gly Ser Asp Leu Lys Gln Gly Phe Ile Ser Ser Leu Lys Ser 
865                 870                 875                 880 


Ala Trp Gln Thr Leu Asn Glu Phe Ala Arg Ala His Thr Ser Ser Thr 
                885                 890                 895     


Gln Leu Gln Glu Glu Leu Glu Lys Val Ala Asn Gln Ile Lys Glu Glu 
            900                 905                 910         


Glu Glu Lys Gln Val Val Glu Ala Glu Lys Val Val Glu Ser Pro Asp 
        915                 920                 925             


Phe Ser Lys Asp Glu Asp Tyr Leu Gly Lys Val Gly Met Leu Asn Gly 
    930                 935                 940                 


Gly Arg Arg Ile Asp Tyr Val Leu Gln Glu Lys Pro Ile Glu Ser Phe 
945                 950                 955                 960 


Asn Glu Tyr Leu Phe Ala Leu Gln Ser His Leu Cys Tyr Trp Glu Ser 
                965                 970                 975     


Glu Asp Thr Ala Leu Leu Leu Leu Lys Glu Ile Tyr Arg Thr Met Asn 
            980                 985                 990         


Ile Ser Pro Glu Gln Pro Gln His  
        995                 1000 


<210> 6206
<211> 164
<212> PRT
<213> Homo sapiens

<400> 6206
Met Val Asn Ser Val Val Phe Phe Asp Ile Thr Val Asp Gly Lys Pro 
1               5                   10                  15      


Leu Gly Arg Ile Ser Ile Lys Leu Phe Ala Asp Lys Ile Leu Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Arg Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Asp Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Asp Asp Glu Asn Leu Ile Arg Lys His Thr Gly Ser Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Ala Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Ala 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Arg Val Asn Ile Val Glu Ala Met Glu His 
    130                 135                 140                 


Phe Gly Tyr Arg Asn Ser Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Phe 
                


<210> 6207
<211> 141
<212> PRT
<213> Homo sapiens

<400> 6207
Met Lys Ile Leu Asp Val Gly Cys Gly Gly Gly Leu Leu Thr Glu Pro 
1               5                   10                  15      


Gly Gly Ser Leu Phe Ile Thr Thr Ile Asn Lys Thr Gln Leu Ser Tyr 
            20                  25                  30          


Ala Leu Gly Ile Val Phe Ser Glu Gln Ile Ala Ser Ile Val Pro Lys 
        35                  40                  45              


Gly Thr His Thr Trp Glu Lys Phe Val Ser Pro Glu Thr Leu Glu Ser 
    50                  55                  60                  


Ile Leu Glu Ser Asn Gly Leu Ser Val Gln Thr Val Val Gly Met Leu 
65                  70                  75                  80  


Tyr Asn Pro Phe Ser Gly Tyr Trp His Trp Ser Glu Asn Thr Ser Leu 
                85                  90                  95      


Asn Tyr Ala Ala Tyr Ala Val Lys Ser Arg Val Gln Glu His Pro Ala 
            100                 105                 110         


Ser Ala Glu Phe Val Leu Lys Gly Glu Thr Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Ala Cys Thr Asn Pro Ala Val His Glu Lys Leu Lys Lys 
    130                 135                 140     


<210> 6208
<211> 141
<212> PRT
<213> Homo sapiens

<400> 6208
Met Lys Ile Leu Asp Val Gly Cys Gly Gly Gly Leu Leu Thr Glu Pro 
1               5                   10                  15      


Gly Gly Ser Leu Phe Ile Thr Thr Ile Asn Lys Thr Gln Leu Ser Tyr 
            20                  25                  30          


Ala Leu Gly Ile Val Phe Ser Glu Gln Ile Ala Ser Ile Val Pro Lys 
        35                  40                  45              


Gly Thr His Thr Trp Glu Lys Phe Val Ser Pro Glu Thr Leu Glu Ser 
    50                  55                  60                  


Ile Leu Glu Ser Asn Gly Leu Ser Val Gln Thr Val Val Gly Met Leu 
65                  70                  75                  80  


Tyr Asn Pro Phe Ser Gly Tyr Trp His Trp Ser Glu Asn Thr Ser Leu 
                85                  90                  95      


Asn Tyr Ala Ala Tyr Ala Val Lys Ser Arg Val Gln Glu His Pro Ala 
            100                 105                 110         


Ser Ala Glu Phe Val Leu Lys Gly Glu Thr Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Ala Cys Thr Asn Pro Ala Val His Glu Lys Leu Lys Lys 
    130                 135                 140     


<210> 6209
<211> 718
<212> PRT
<213> Homo sapiens

<400> 6209
Met Leu Met Thr Leu Glu Met Thr Glu Leu Thr Asp Pro His His Thr 
1               5                   10                  15      


Met Gly Asp Tyr Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
            20                  25                  30          


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
        35                  40                  45              


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
    50                  55                  60                  


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
65                  70                  75                  80  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
                85                  90                  95      


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
            100                 105                 110         


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
        115                 120                 125             


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
    130                 135                 140                 


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
145                 150                 155                 160 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
                165                 170                 175     


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
            180                 185                 190         


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
        195                 200                 205             


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
    210                 215                 220                 


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
225                 230                 235                 240 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
                245                 250                 255     


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
            260                 265                 270         


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
        275                 280                 285             


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
    290                 295                 300                 


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
305                 310                 315                 320 


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
                325                 330                 335     


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
            340                 345                 350         


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
        355                 360                 365             


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
    370                 375                 380                 


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
385                 390                 395                 400 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
                405                 410                 415     


Phe His Arg Pro Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
            420                 425                 430         


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
        435                 440                 445             


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
    450                 455                 460                 


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
465                 470                 475                 480 


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
                485                 490                 495     


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
            500                 505                 510         


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
        515                 520                 525             


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
    530                 535                 540                 


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
545                 550                 555                 560 


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
                565                 570                 575     


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
            580                 585                 590         


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
        595                 600                 605             


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
    610                 615                 620                 


Val Arg Asp Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
625                 630                 635                 640 


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
                645                 650                 655     


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
            660                 665                 670         


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
        675                 680                 685             


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
    690                 695                 700                 


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
705                 710                 715             


<210> 6210
<211> 530
<212> PRT
<213> Homo sapiens

<400> 6210
Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
1               5                   10                  15      


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu 
            20                  25                  30          


Pro Asn Ile Arg Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu 
        35                  40                  45              


Ile Arg Arg Thr Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser 
    50                  55                  60                  


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
65                  70                  75                  80  


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
                85                  90                  95      


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
            100                 105                 110         


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
        115                 120                 125             


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
    130                 135                 140                 


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
145                 150                 155                 160 


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
                165                 170                 175     


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
            180                 185                 190         


Glu Leu Leu Ser Pro Gly Val Gln Arg Leu Ser Tyr Leu Arg Thr Ser 
        195                 200                 205             


Ser Leu Ser Pro Thr His Ser Asp Ser Arg Pro Asn Pro Pro Phe Arg 
    210                 215                 220                 


His His Phe Ile Pro His Ile Lys Gly Asn Glu Pro Ser Ser Gly Arg 
225                 230                 235                 240 


Asn Ser Pro Leu Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr 
                245                 250                 255     


Tyr Ala Gln Ala Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn 
            260                 265                 270         


Ile Tyr Arg Lys Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala 
        275                 280                 285             


Gln Ser Lys Ser Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala 
    290                 295                 300                 


Ala Gln Ala Pro Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His 
305                 310                 315                 320 


Trp Pro Gly Pro Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg 
                325                 330                 335     


Arg Ser Ser Gly Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg 
            340                 345                 350         


Gln Leu Gln Glu Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln 
        355                 360                 365             


Leu Ile Leu Lys Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser 
    370                 375                 380                 


Leu Leu Ala Ser Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile 
385                 390                 395                 400 


Pro Ser Ser Lys Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu 
                405                 410                 415     


His Arg Pro Val Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp 
            420                 425                 430         


Val Ser Gly Gly Val Arg Asp Tyr Gln Thr Leu Pro Asp Gly His Met 
        435                 440                 445             


Pro Ala Met Arg Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu 
    450                 455                 460                 


Pro Lys Ile Phe Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg 
465                 470                 475                 480 


Asn Lys Ile Leu Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu 
                485                 490                 495     


Ala Pro Glu Val Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe 
            500                 505                 510         


Asp Arg Leu Pro Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys 
        515                 520                 525             


Leu Phe 
    530 


<210> 6211
<211> 702
<212> PRT
<213> Homo sapiens

<400> 6211
Met Val Lys Glu Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
1               5                   10                  15      


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
            20                  25                  30          


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
        35                  40                  45              


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
    50                  55                  60                  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
                85                  90                  95      


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
            100                 105                 110         


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
        115                 120                 125             


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
    130                 135                 140                 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
145                 150                 155                 160 


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
                165                 170                 175     


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
            180                 185                 190         


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
        195                 200                 205             


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
    210                 215                 220                 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
225                 230                 235                 240 


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
                245                 250                 255     


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
            260                 265                 270         


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
        275                 280                 285             


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
    290                 295                 300                 


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
305                 310                 315                 320 


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
                325                 330                 335     


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
            340                 345                 350         


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
        355                 360                 365             


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
    370                 375                 380                 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
385                 390                 395                 400 


Phe His Arg Pro Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
                405                 410                 415     


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
            420                 425                 430         


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
        435                 440                 445             


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
    450                 455                 460                 


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
465                 470                 475                 480 


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
                485                 490                 495     


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
            500                 505                 510         


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
        515                 520                 525             


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
    530                 535                 540                 


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
545                 550                 555                 560 


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
                565                 570                 575     


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
            580                 585                 590         


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
        595                 600                 605             


Val Arg Asp Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
    610                 615                 620                 


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
625                 630                 635                 640 


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
                645                 650                 655     


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
            660                 665                 670         


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
        675                 680                 685             


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
    690                 695                 700         


<210> 6212
<211> 401
<212> PRT
<213> Homo sapiens

<400> 6212
Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
1               5                   10                  15      


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Ala 
            20                  25                  30          


Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro 
        35                  40                  45              


Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr 
    50                  55                  60                  


Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser 
65                  70                  75                  80  


Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly 
                85                  90                  95      


Tyr Gln Asp Val Arg Asp Arg Met Ile His Arg Ser Thr Ser Gln Gly 
            100                 105                 110         


Ser Ile Asn Ser Pro Val Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr 
        115                 120                 125             


Ser Arg Ser Pro Gln His Phe His Arg Pro Asp Gln Gly Ile Asn Ile 
    130                 135                 140                 


Tyr Arg Lys Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln 
145                 150                 155                 160 


Ser Lys Ser Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala 
                165                 170                 175     


Gln Ala Pro Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp 
            180                 185                 190         


Pro Gly Pro Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg 
        195                 200                 205             


Ser Ser Gly Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln 
    210                 215                 220                 


Leu Gln Glu Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu 
225                 230                 235                 240 


Ile Leu Lys Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu 
                245                 250                 255     


Leu Ala Ser Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro 
            260                 265                 270         


Ser Ser Lys Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His 
        275                 280                 285             


Arg Pro Val Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val 
    290                 295                 300                 


Ser Gly Gly Val Arg Asp Tyr Gln Thr Leu Pro Asp Gly His Met Pro 
305                 310                 315                 320 


Ala Met Arg Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro 
                325                 330                 335     


Lys Ile Phe Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn 
            340                 345                 350         


Lys Ile Leu Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala 
        355                 360                 365             


Pro Glu Val Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp 
    370                 375                 380                 


Arg Leu Pro Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu 
385                 390                 395                 400 


Phe 
    


<210> 6213
<211> 655
<212> PRT
<213> Homo sapiens

<400> 6213
Met Val Lys Glu Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
1               5                   10                  15      


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
            20                  25                  30          


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
        35                  40                  45              


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
    50                  55                  60                  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
                85                  90                  95      


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
            100                 105                 110         


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
        115                 120                 125             


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
    130                 135                 140                 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
145                 150                 155                 160 


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
                165                 170                 175     


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
            180                 185                 190         


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
        195                 200                 205             


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
    210                 215                 220                 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
225                 230                 235                 240 


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
                245                 250                 255     


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
            260                 265                 270         


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
        275                 280                 285             


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
    290                 295                 300                 


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
305                 310                 315                 320 


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
                325                 330                 335     


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
            340                 345                 350         


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
        355                 360                 365             


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
    370                 375                 380                 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
385                 390                 395                 400 


Phe His Arg Pro Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
                405                 410                 415     


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
            420                 425                 430         


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
        435                 440                 445             


Pro Pro Ile Tyr Lys Gln His Gly Pro Asp Met Lys Arg Arg Ser Ser 
    450                 455                 460                 


Gly Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln 
465                 470                 475                 480 


Glu Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu 
                485                 490                 495     


Lys Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala 
            500                 505                 510         


Ser Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser 
        515                 520                 525             


Lys Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro 
    530                 535                 540                 


Val Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly 
545                 550                 555                 560 


Gly Val Arg Asp Phe Gln Thr Leu Pro Asp Gly His Met Pro Ala Met 
                565                 570                 575     


Arg Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile 
            580                 585                 590         


Phe Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile 
        595                 600                 605             


Leu Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu 
    610                 615                 620                 


Val Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu 
625                 630                 635                 640 


Pro Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
                645                 650                 655 


<210> 6214
<211> 846
<212> PRT
<213> Homo sapiens

<400> 6214
Met Pro Ala Phe Leu Gly Leu Lys Cys Leu Gly Lys Leu Cys Ser Ser 
1               5                   10                  15      


Glu Lys Ser Lys Val Thr Ser Ser Glu Arg Thr Ser Ala Arg Gly Ser 
            20                  25                  30          


Asn Arg Lys Arg Leu Ile Val Glu Asp Arg Arg Val Ser Gly Thr Ser 
        35                  40                  45              


Phe Thr Ala His Arg Arg Ala Thr Ile Thr His Leu Leu Tyr Leu Cys 
    50                  55                  60                  


Pro Lys Asp Tyr Cys Pro Arg Gly Arg Val Cys Asn Ser Val Asp Pro 
65                  70                  75                  80  


Phe Val Ala His Pro Gln Asp Pro His His Pro Ser Glu Lys Pro Val 
                85                  90                  95      


Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly Glu Val Leu Arg 
            100                 105                 110         


Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr Cys Lys Val Cys 
        115                 120                 125             


Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys Asn Gly Glu Tyr 
    130                 135                 140                 


Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr Arg Cys His Gly 
145                 150                 155                 160 


Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala Leu Gly Lys Thr 
                165                 170                 175     


Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys Arg Pro Phe Pro 
            180                 185                 190         


Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys Leu Cys Gln Leu 
        195                 200                 205             


Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr Thr Phe Ser Ser 
    210                 215                 220                 


Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly Gln Ala Leu Leu 
225                 230                 235                 240 


Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys Cys Lys Ser Cys 
                245                 250                 255     


Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp Gly Ala Pro Tyr 
            260                 265                 270         


Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys Cys Glu Ala Cys 
        275                 280                 285             


His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly Asp Lys His Tyr 
    290                 295                 300                 


His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln Met Phe Thr Glu 
305                 310                 315                 320 


Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp His Pro Asp Cys 
                325                 330                 335     


Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu Pro Asn Ile Arg 
            340                 345                 350         


Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu Ile Arg Arg Thr 
        355                 360                 365             


Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser Ser Glu Ser Ile 
    370                 375                 380                 


Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro Gly His Thr Ile 
385                 390                 395                 400 


Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys Asp Leu Ala Ala 
                405                 410                 415     


Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg Pro Asp Leu Ile 
            420                 425                 430         


Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp Lys Gln Glu Arg 
        435                 440                 445             


Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro Thr Pro Ser Ala 
    450                 455                 460                 


Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His Arg Ser Thr Ser 
465                 470                 475                 480 


Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His Ser Tyr Thr Pro 
                485                 490                 495     


Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro Glu Leu Leu Ser 
            500                 505                 510         


Pro Gly Val Gln Arg Leu Ser Tyr Leu Arg Thr Ser Ser Leu Ser Pro 
        515                 520                 525             


Thr His Ser Asp Ser Arg Pro Asn Pro Pro Phe Arg His His Phe Ile 
    530                 535                 540                 


Pro His Ile Lys Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
545                 550                 555                 560 


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
                565                 570                 575     


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
            580                 585                 590         


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
        595                 600                 605             


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
    610                 615                 620                 


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
625                 630                 635                 640 


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
                645                 650                 655     


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
            660                 665                 670         


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
        675                 680                 685             


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
    690                 695                 700                 


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
705                 710                 715                 720 


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
                725                 730                 735     


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
            740                 745                 750         


Val Arg Glu Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
        755                 760                 765             


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
    770                 775                 780                 


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
785                 790                 795                 800 


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
                805                 810                 815     


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
            820                 825                 830         


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
        835                 840                 845     


<210> 6215
<211> 702
<212> PRT
<213> Homo sapiens

<400> 6215
Met Val Pro Asp Pro Val Ala His Pro Gln Asp Pro His His Pro Ser 
1               5                   10                  15      


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
            20                  25                  30          


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
        35                  40                  45              


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
    50                  55                  60                  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
                85                  90                  95      


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
            100                 105                 110         


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
        115                 120                 125             


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
    130                 135                 140                 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
145                 150                 155                 160 


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
                165                 170                 175     


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
            180                 185                 190         


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
        195                 200                 205             


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
    210                 215                 220                 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
225                 230                 235                 240 


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
                245                 250                 255     


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
            260                 265                 270         


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
        275                 280                 285             


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
    290                 295                 300                 


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
305                 310                 315                 320 


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
                325                 330                 335     


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
            340                 345                 350         


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
        355                 360                 365             


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
    370                 375                 380                 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
385                 390                 395                 400 


Phe His Arg Pro Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
                405                 410                 415     


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
            420                 425                 430         


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
        435                 440                 445             


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
    450                 455                 460                 


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
465                 470                 475                 480 


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
                485                 490                 495     


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
            500                 505                 510         


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
        515                 520                 525             


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
    530                 535                 540                 


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
545                 550                 555                 560 


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
                565                 570                 575     


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
            580                 585                 590         


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
        595                 600                 605             


Val Arg Glu Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
    610                 615                 620                 


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
625                 630                 635                 640 


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
                645                 650                 655     


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
            660                 665                 670         


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
        675                 680                 685             


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
    690                 695                 700         


<210> 6216
<211> 455
<212> PRT
<213> Homo sapiens

<400> 6216
Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
1               5                   10                  15      


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu 
            20                  25                  30          


Pro Asn Ile Arg Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu 
        35                  40                  45              


Ile Arg Arg Thr Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser 
    50                  55                  60                  


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
65                  70                  75                  80  


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
                85                  90                  95      


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
            100                 105                 110         


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
        115                 120                 125             


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
    130                 135                 140                 


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
145                 150                 155                 160 


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
                165                 170                 175     


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
            180                 185                 190         


Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr Lys Gln His 
        195                 200                 205             


Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile Ile Lys Phe 
    210                 215                 220                 


Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu Thr Pro Lys 
225                 230                 235                 240 


Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala Val Val Gly 
                245                 250                 255     


Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp Asp Glu Glu 
            260                 265                 270         


Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met Lys Leu Asn 
        275                 280                 285             


Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu Lys Glu Ser 
    290                 295                 300                 


Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser Pro Ile Asn 
305                 310                 315                 320 


Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu Pro Gly Tyr 
                325                 330                 335     


Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe Ala Gln Tyr 
            340                 345                 350         


Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Phe Gln Thr Leu 
        355                 360                 365             


Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly Val Ser Met 
    370                 375                 380                 


Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met Leu Met Val 
385                 390                 395                 400 


Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp Arg Thr Arg 
                405                 410                 415     


Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile Phe Gly Met 
            420                 425                 430         


Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg Asn Asp Met 
        435                 440                 445             


Lys Lys Lys Ala Lys Leu Phe 
    450                 455 


<210> 6217
<211> 746
<212> PRT
<213> Homo sapiens

<400> 6217
Met Leu Met Thr Leu Glu Met Thr Glu Leu Thr Asp Pro His His Thr 
1               5                   10                  15      


Met Gly Asp Tyr Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
            20                  25                  30          


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
        35                  40                  45              


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
    50                  55                  60                  


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
65                  70                  75                  80  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
                85                  90                  95      


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
            100                 105                 110         


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
        115                 120                 125             


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
    130                 135                 140                 


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
145                 150                 155                 160 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
                165                 170                 175     


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
            180                 185                 190         


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
        195                 200                 205             


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
    210                 215                 220                 


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
225                 230                 235                 240 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
                245                 250                 255     


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
            260                 265                 270         


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu 
        275                 280                 285             


Pro Asn Ile Arg Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu 
    290                 295                 300                 


Ile Arg Arg Thr Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser 
305                 310                 315                 320 


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
                325                 330                 335     


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
            340                 345                 350         


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
        355                 360                 365             


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
    370                 375                 380                 


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
385                 390                 395                 400 


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
                405                 410                 415     


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
            420                 425                 430         


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
        435                 440                 445             


Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu Pro Tyr Arg Pro 
    450                 455                 460                 


Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala Pro Lys His Phe 
465                 470                 475                 480 


His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr 
                485                 490                 495     


Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile 
            500                 505                 510         


Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu 
        515                 520                 525             


Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala 
    530                 535                 540                 


Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp 
545                 550                 555                 560 


Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met 
                565                 570                 575     


Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu 
            580                 585                 590         


Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser 
        595                 600                 605             


Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu 
    610                 615                 620                 


Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe 
625                 630                 635                 640 


Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Phe 
                645                 650                 655     


Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly 
            660                 665                 670         


Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met 
        675                 680                 685             


Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp 
    690                 695                 700                 


Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile 
705                 710                 715                 720 


Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg 
                725                 730                 735     


Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
            740                 745     


<210> 6218
<211> 304
<212> PRT
<213> Homo sapiens

<400> 6218
Met Ala Glu Ala Ser Ala Ala Gly Ala Asp Ser Gly Ala Ala Val Ala 
1               5                   10                  15      


Ala His Arg Phe Phe Cys His Phe Cys Lys Gly Glu Val Ser Pro Lys 
            20                  25                  30          


Leu Pro Glu Tyr Ile Cys Pro Arg Cys Glu Ser Gly Phe Ile Glu Glu 
        35                  40                  45              


Val Thr Asp Asp Ser Ser Phe Leu Gly Gly Gly Gly Ser Arg Ile Asp 
    50                  55                  60                  


Asn Thr Thr Thr Thr His Phe Ala Glu Leu Trp Gly His Leu Asp His 
65                  70                  75                  80  


Thr Met Phe Phe Gln Asp Phe Arg Pro Phe Leu Ser Ser Ser Pro Leu 
                85                  90                  95      


Asp Gln Asp Asn Arg Ala Asn Glu Arg Gly His Gln Thr His Thr Asp 
            100                 105                 110         


Phe Trp Gly Ala Arg Pro Pro Arg Leu Pro Leu Gly Arg Arg Tyr Arg 
        115                 120                 125             


Ser Arg Gly Ser Ser Arg Pro Asp Arg Ser Pro Ala Ile Glu Gly Ile 
    130                 135                 140                 


Leu Gln His Ile Phe Ala Gly Phe Phe Ala Asn Ser Ala Ile Pro Gly 
145                 150                 155                 160 


Ser Pro His Pro Phe Ser Trp Ser Gly Met Leu His Ser Asn Pro Gly 
                165                 170                 175     


Asp Tyr Ala Trp Gly Gln Thr Gly Leu Asp Ala Ile Val Thr Gln Leu 
            180                 185                 190         


Leu Gly Gln Leu Glu Asn Thr Gly Pro Pro Pro Ala Asp Lys Glu Lys 
        195                 200                 205             


Ile Thr Ser Leu Pro Thr Val Thr Val Thr Gln Glu Gln Val Asp Met 
    210                 215                 220                 


Gly Leu Glu Cys Pro Val Cys Lys Glu Asp Tyr Thr Val Glu Glu Glu 
225                 230                 235                 240 


Val Arg Gln Leu Pro Cys Asn His Phe Phe His Ser Ser Cys Ile Val 
                245                 250                 255     


Pro Trp Leu Glu Leu His Asp Thr Cys Pro Val Cys Arg Lys Ser Leu 
            260                 265                 270         


Asn Gly Glu Asp Ser Thr Arg Gln Ser Gln Ser Thr Glu Ala Ser Ala 
        275                 280                 285             


Ser Asn Arg Phe Ser Asn Asp Ser Gln Leu His Asp Arg Trp Thr Phe 
    290                 295                 300                 


<210> 6219
<211> 211
<212> PRT
<213> Homo sapiens

<400> 6219
Met Ser Cys Thr Ile Glu Lys Ile Leu Thr Asp Ala Lys Thr Leu Leu 
1               5                   10                  15      


Glu Arg Leu Arg Glu His Asp Ala Ala Ala Glu Ser Leu Val Asp Gln 
            20                  25                  30          


Ser Ala Ala Leu His Arg Arg Val Ala Ala Met Arg Glu Ala Gly Thr 
        35                  40                  45              


Ala Leu Pro Asp Gln Val Arg Gln Arg Tyr Gln Glu Asp Ala Ser Asp 
    50                  55                  60                  


Met Lys Asp Met Ser Lys Tyr Lys Pro His Ile Leu Leu Ser Gln Glu 
65                  70                  75                  80  


Asn Thr Gln Ile Arg Asp Leu Gln Gln Glu Asn Arg Glu Leu Trp Ile 
                85                  90                  95      


Ser Leu Glu Glu His Gln Asp Ala Leu Glu Leu Ile Met Ser Lys Tyr 
            100                 105                 110         


Arg Lys Gln Met Leu Gln Leu Met Val Ala Lys Lys Ala Val Asp Ala 
        115                 120                 125             


Glu Pro Val Leu Lys Ala His Gln Ser His Ser Ala Glu Ile Glu Ser 
    130                 135                 140                 


Gln Ile Asp Arg Ile Cys Glu Met Gly Glu Val Met Arg Lys Ala Val 
145                 150                 155                 160 


Gln Val Asp Asp Asp Gln Phe Cys Lys Ile Gln Glu Lys Leu Ala Gln 
                165                 170                 175     


Leu Glu Leu Glu Asn Lys Glu Leu Arg Glu Leu Leu Ser Ile Ser Ser 
            180                 185                 190         


Glu Ser Leu Gln Ala Arg Lys Glu Asn Ser Met Asp Thr Ala Ser Gln 
        195                 200                 205             


Ala Ile Lys 
    210     


<210> 6220
<211> 816
<212> PRT
<213> Homo sapiens

<400> 6220
Met Val Leu Met Phe Gln Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu 
1               5                   10                  15      


Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe 
            20                  25                  30          


Asn Arg Asp Pro Asn Leu Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro 
        35                  40                  45              


Glu Glu His Glu Leu Glu Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys 
    50                  55                  60                  


Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn Met Ser Thr 
65                  70                  75                  80  


Asp Leu Glu Gly Thr Asp Met Leu Ala Glu Lys Ala Asp Arg Arg Glu 
                85                  90                  95      


Tyr Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala Asp Lys Arg 
            100                 105                 110         


Ile Thr Pro Leu Lys Thr Leu Asn His Gln Phe Val Thr Met Thr His 
        115                 120                 125             


Leu Leu Asp Phe Pro His Ser Asn His Val Lys Ser Cys Phe Gln Asn 
    130                 135                 140                 


Met Glu Ile Cys Lys Arg Arg Val His Met Tyr Asp Thr Val Ser Gln 
145                 150                 155                 160 


Ile Lys Ser Pro Phe Thr Thr His Val Ala Pro Asn Thr Ser Thr Asn 
                165                 170                 175     


Leu Thr Met Ser Phe Ser Asn Gln Leu Asn Thr Val His Asn Gln Ala 
            180                 185                 190         


Ser Val Leu Ala Ser Ser Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu 
        195                 200                 205             


Ala Asn Ser Asp Val Ser Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro 
    210                 215                 220                 


Ser Ser Ala Ala Pro Val Pro Gly Val Ala Gln Gln Gly Val Ser Leu 
225                 230                 235                 240 


Gln Pro Gly Thr Thr Gln Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln 
                245                 250                 255     


Thr Phe Ile Val Cys Pro Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr 
            260                 265                 270         


Thr Lys His Ser Gly Phe Pro Val Arg Met Asp Asn Ala Val Pro Ile 
        275                 280                 285             


Val Pro Gln Ala Pro Ala Ala Gln Pro Leu Gln Ile Gln Ser Gly Val 
    290                 295                 300                 


Leu Thr Gln Gly Ser Cys Thr Pro Leu Met Val Ala Thr Leu His Pro 
305                 310                 315                 320 


Gln Val Ala Thr Ile Thr Pro Gln Tyr Ala Val Pro Phe Thr Leu Ser 
                325                 330                 335     


Cys Ala Ala Gly Arg Pro Ala Leu Val Glu Gln Thr Ala Ala Val Leu 
            340                 345                 350         


Gln Ala Trp Pro Gly Gly Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp 
        355                 360                 365             


Gln Gln Leu Pro Gly Val Ala Leu His Asn Ser Val Gln Pro Thr Ala 
    370                 375                 380                 


Met Ile Pro Glu Ala Met Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg 
385                 390                 395                 400 


Asn Ala His Ser His Gly Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro 
                405                 410                 415     


Ser Leu Leu Thr Asn His Val Thr Leu Ala Thr Ala Gln Pro Leu Asn 
            420                 425                 430         


Val Gly Val Ala His Val Val Arg Gln Gln Gln Ser Ser Ser Leu Pro 
        435                 440                 445             


Ser Lys Lys Asn Lys Gln Ser Ala Pro Val Ser Ser Lys Ser Ser Leu 
    450                 455                 460                 


Asp Val Leu Pro Ser Gln Val Tyr Ser Leu Val Gly Ser Ser Pro Leu 
465                 470                 475                 480 


Arg Thr Thr Ser Ser Tyr Asn Ser Leu Val Pro Val Gln Asp Gln His 
                485                 490                 495     


Gln Pro Ile Ile Ile Pro Asp Thr Pro Ser Pro Pro Val Ser Val Ile 
            500                 505                 510         


Thr Ile Arg Ser Asp Thr Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro 
        515                 520                 525             


Ser Ser Ser Gly Leu Lys Pro Arg Ser Asn Val Ile Ser Tyr Val Thr 
    530                 535                 540                 


Val Asn Asp Ser Pro Asp Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser 
545                 550                 555                 560 


Thr Asp Thr Leu Ser Ala Leu Arg Gly Asn Ser Gly Ser Val Leu Glu 
                565                 570                 575     


Gly Pro Gly Arg Val Val Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile 
            580                 585                 590         


Val Pro Pro Leu Lys Thr Gln Leu Gly Asp Cys Thr Val Ala Thr Gln 
        595                 600                 605             


Ala Ser Gly Leu Leu Ser Asn Lys Thr Lys Pro Val Ala Ser Val Ser 
    610                 615                 620                 


Gly Gln Ser Ser Gly Cys Cys Ile Thr Pro Thr Gly Tyr Arg Ala Gln 
625                 630                 635                 640 


Arg Gly Gly Thr Ser Ala Ala Gln Pro Leu Asn Leu Ser Gln Asn Gln 
                645                 650                 655     


Gln Ser Ser Ala Ala Pro Thr Ser Gln Glu Arg Ser Ser Asn Pro Ala 
            660                 665                 670         


Pro Arg Arg Gln Gln Ala Phe Val Ala Pro Leu Ser Gln Ala Pro Tyr 
        675                 680                 685             


Thr Phe Gln His Gly Ser Pro Leu His Ser Thr Gly His Pro His Leu 
    690                 695                 700                 


Ala Pro Ala Pro Ala His Leu Pro Ser Gln Ala His Leu Tyr Thr Tyr 
705                 710                 715                 720 


Ala Ala Pro Thr Ser Ala Ala Ala Leu Gly Ser Thr Ser Ser Ile Ala 
                725                 730                 735     


His Leu Phe Ser Pro Gln Gly Ser Ser Arg His Ala Ala Ala Tyr Thr 
            740                 745                 750         


Thr His Pro Ser Thr Leu Val His Gln Val Pro Val Ser Val Gly Pro 
        755                 760                 765             


Ser Leu Leu Thr Ser Ala Ser Val Ala Pro Ala Gln Tyr Gln His Gln 
    770                 775                 780                 


Phe Ala Thr Gln Ser Tyr Ile Gly Ser Ser Arg Gly Ser Thr Ile Tyr 
785                 790                 795                 800 


Thr Gly Tyr Pro Leu Ser Pro Thr Lys Ile Ser Gln Tyr Ser Tyr Leu 
                805                 810                 815     


<210> 6221
<211> 1165
<212> PRT
<213> Homo sapiens

<400> 6221
Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu Thr His Arg Ser Asn Val 
            100                 105                 110         


Ser Leu Leu Glu Pro Tyr Gln Lys Cys Gly Leu Lys Arg Lys Ser Glu 
        115                 120                 125             


Glu Val Asp Ser Asn Gly Ser Val Gln Ile Ile Glu Glu His Pro Pro 
    130                 135                 140                 


Leu Met Leu Gln Asn Arg Thr Val Val Gly Ala Ala Ala Thr Thr Thr 
145                 150                 155                 160 


Thr Val Thr Thr Lys Ser Ser Ser Ser Ser Gly Glu Gly Asp Tyr Gln 
                165                 170                 175     


Leu Val Gln His Glu Ile Leu Cys Ser Met Thr Asn Ser Tyr Glu Val 
            180                 185                 190         


Leu Glu Phe Leu Gly Arg Gly Thr Phe Gly Gln Val Ala Lys Cys Trp 
        195                 200                 205             


Lys Arg Ser Thr Lys Glu Ile Val Ala Ile Lys Ile Leu Lys Asn His 
    210                 215                 220                 


Pro Ser Tyr Ala Arg Gln Gly Gln Ile Glu Val Ser Ile Leu Ser Arg 
225                 230                 235                 240 


Leu Ser Ser Glu Asn Ala Asp Glu Tyr Asn Phe Val Arg Ser Tyr Glu 
                245                 250                 255     


Cys Phe Gln His Lys Asn His Thr Cys Leu Val Phe Glu Met Leu Glu 
            260                 265                 270         


Gln Asn Leu Tyr Asp Phe Leu Lys Gln Asn Lys Phe Ser Pro Leu Pro 
        275                 280                 285             


Leu Lys Tyr Ile Arg Pro Ile Leu Gln Gln Val Ala Thr Ala Leu Met 
    290                 295                 300                 


Lys Leu Lys Ser Leu Gly Leu Ile His Ala Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Met Leu Val Asp Pro Val Arg Gln Pro Tyr Arg Val Lys Val Ile 
                325                 330                 335     


Asp Phe Gly Ser Ala Ser His Val Ser Lys Ala Val Cys Ser Thr Tyr 
            340                 345                 350         


Leu Gln Ser Arg Tyr Tyr Arg Ala Pro Glu Ile Ile Leu Gly Leu Pro 
        355                 360                 365             


Phe Cys Glu Ala Ile Asp Met Trp Ser Leu Gly Cys Val Ile Ala Glu 
    370                 375                 380                 


Leu Phe Leu Gly Trp Pro Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gln 
385                 390                 395                 400 


Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu Pro Ala Glu Tyr Leu Leu 
                405                 410                 415     


Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe Asn Arg Asp Pro Asn Leu 
            420                 425                 430         


Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro Glu Glu His Glu Leu Glu 
        435                 440                 445             


Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys Tyr Ile Phe Asn Cys Leu 
    450                 455                 460                 


Asp Asp Met Ala Gln Val Asn Met Ser Thr Asp Leu Glu Gly Thr Asp 
465                 470                 475                 480 


Met Leu Ala Glu Lys Ala Asp Arg Arg Glu Tyr Ile Asp Leu Leu Lys 
                485                 490                 495     


Lys Met Leu Thr Ile Asp Ala Asp Lys Arg Ile Thr Pro Leu Lys Thr 
            500                 505                 510         


Leu Asn His Gln Phe Val Thr Met Thr His Leu Leu Asp Phe Pro His 
        515                 520                 525             


Ser Asn His Val Lys Ser Cys Phe Gln Asn Met Glu Ile Cys Lys Arg 
    530                 535                 540                 


Arg Val His Met Tyr Asp Thr Val Ser Gln Ile Lys Ser Pro Phe Thr 
545                 550                 555                 560 


Thr His Val Ala Pro Asn Thr Ser Thr Asn Leu Thr Met Ser Phe Ser 
                565                 570                 575     


Asn Gln Leu Asn Thr Val His Asn Gln Ala Ser Val Leu Ala Ser Ser 
            580                 585                 590         


Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu Ala Asn Ser Asp Val Ser 
        595                 600                 605             


Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro Ser Ser Ala Ala Pro Val 
    610                 615                 620                 


Pro Gly Val Ala Gln Gln Gly Val Ser Leu Gln Pro Gly Thr Thr Gln 
625                 630                 635                 640 


Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln Thr Phe Ile Val Cys Pro 
                645                 650                 655     


Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr Thr Lys His Ser Gly Phe 
            660                 665                 670         


Pro Val Arg Met Asp Asn Ala Val Pro Ile Val Pro Gln Ala Pro Ala 
        675                 680                 685             


Ala Gln Pro Leu Gln Ile Gln Ser Gly Val Leu Thr Gln Gln Ala Trp 
    690                 695                 700                 


Pro Gly Gly Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp Gln Gln Leu 
705                 710                 715                 720 


Pro Gly Val Ala Leu His Asn Ser Val Gln Pro Thr Ala Met Ile Pro 
                725                 730                 735     


Glu Ala Met Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg Asn Ala His 
            740                 745                 750         


Ser His Gly Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro Ser Leu Leu 
        755                 760                 765             


Thr Asn His Val Thr Leu Ala Thr Ala Gln Pro Leu Asn Val Gly Val 
    770                 775                 780                 


Ala His Val Val Arg Gln Gln Gln Ser Ser Ser Leu Pro Ser Lys Lys 
785                 790                 795                 800 


Asn Lys Gln Ser Ala Pro Val Ser Ser Lys Ser Ser Leu Asp Val Leu 
                805                 810                 815     


Pro Ser Gln Val Tyr Ser Leu Val Gly Ser Ser Pro Leu Arg Thr Thr 
            820                 825                 830         


Ser Ser Tyr Asn Ser Leu Val Pro Val Gln Asp Gln His Gln Pro Ile 
        835                 840                 845             


Ile Ile Pro Asp Thr Pro Ser Pro Pro Val Ser Val Ile Thr Ile Arg 
    850                 855                 860                 


Ser Asp Thr Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro Ser Ser Ser 
865                 870                 875                 880 


Gly Leu Lys Pro Arg Ser Asn Val Ile Ser Tyr Val Thr Val Asn Asp 
                885                 890                 895     


Ser Pro Asp Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser Thr Asp Thr 
            900                 905                 910         


Leu Ser Ala Leu Arg Gly Asn Ser Gly Ser Val Leu Glu Gly Pro Gly 
        915                 920                 925             


Arg Val Val Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile Val Pro Pro 
    930                 935                 940                 


Leu Lys Thr Gln Leu Gly Asp Cys Thr Val Ala Thr Gln Ala Ser Gly 
945                 950                 955                 960 


Leu Leu Ser Asn Lys Thr Lys Pro Val Ala Ser Val Ser Gly Gln Ser 
                965                 970                 975     


Ser Gly Cys Cys Ile Thr Pro Thr Gly Tyr Arg Ala Gln Arg Gly Gly 
            980                 985                 990         


Thr Ser Ala Ala Gln Pro Leu Asn  Leu Ser Gln Asn Gln  Gln Ser Ser 
        995                 1000                 1005             


Ala Ala  Pro Thr Ser Gln Glu  Arg Ser Ser Asn Pro  Ala Pro Arg 
    1010                 1015                 1020             


Arg Gln  Gln Ala Phe Val Ala  Pro Leu Ser Gln Ala  Pro Tyr Thr 
    1025                 1030                 1035             


Phe Gln  His Gly Ser Pro Leu  His Ser Thr Gly His  Pro His Leu 
    1040                 1045                 1050             


Ala Pro  Ala Pro Ala His Leu  Pro Ser Gln Ala His  Leu Tyr Thr 
    1055                 1060                 1065             


Tyr Ala  Ala Pro Thr Ser Ala  Ala Ala Leu Gly Ser  Thr Ser Ser 
    1070                 1075                 1080             


Ile Ala  His Leu Phe Ser Pro  Gln Gly Ser Ser Arg  His Ala Ala 
    1085                 1090                 1095             


Ala Tyr  Thr Thr His Pro Ser  Thr Leu Val His Gln  Val Pro Val 
    1100                 1105                 1110             


Ser Val  Gly Pro Ser Leu Leu  Thr Ser Ala Ser Val  Ala Pro Ala 
    1115                 1120                 1125             


Gln Tyr  Gln His Gln Phe Ala  Thr Gln Ser Tyr Ile  Gly Ser Ser 
    1130                 1135                 1140             


Arg Gly  Ser Thr Ile Tyr Thr  Gly Tyr Pro Leu Ser  Pro Thr Lys 
    1145                 1150                 1155             


Ile Ser  Gln Tyr Ser Tyr Leu  
    1160                 1165 


<210> 6222
<211> 1165
<212> PRT
<213> Homo sapiens

<400> 6222
Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu Thr His Arg Ser Asn Val 
            100                 105                 110         


Ser Leu Leu Glu Pro Tyr Gln Lys Cys Gly Leu Lys Arg Lys Ser Glu 
        115                 120                 125             


Glu Val Asp Ser Asn Gly Ser Val Gln Ile Ile Glu Glu His Pro Pro 
    130                 135                 140                 


Leu Met Leu Gln Asn Arg Thr Val Val Gly Ala Ala Ala Thr Thr Thr 
145                 150                 155                 160 


Thr Val Thr Thr Lys Ser Ser Ser Ser Ser Gly Glu Gly Asp Tyr Gln 
                165                 170                 175     


Leu Val Gln His Glu Ile Leu Cys Ser Met Thr Asn Ser Tyr Glu Val 
            180                 185                 190         


Leu Glu Phe Leu Gly Arg Gly Thr Phe Gly Gln Val Ala Lys Cys Trp 
        195                 200                 205             


Lys Arg Ser Thr Lys Glu Ile Val Ala Ile Lys Ile Leu Lys Asn His 
    210                 215                 220                 


Pro Ser Tyr Ala Arg Gln Gly Gln Ile Glu Val Ser Ile Leu Ser Arg 
225                 230                 235                 240 


Leu Ser Ser Glu Asn Ala Asp Glu Tyr Asn Phe Val Arg Ser Tyr Glu 
                245                 250                 255     


Cys Phe Gln His Lys Asn His Thr Cys Leu Val Phe Glu Met Leu Glu 
            260                 265                 270         


Gln Asn Leu Tyr Asp Phe Leu Lys Gln Asn Lys Phe Ser Pro Leu Pro 
        275                 280                 285             


Leu Lys Tyr Ile Arg Pro Ile Leu Gln Gln Val Ala Thr Ala Leu Met 
    290                 295                 300                 


Lys Leu Lys Ser Leu Gly Leu Ile His Ala Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Met Leu Val Asp Pro Val Arg Gln Pro Tyr Arg Val Lys Val Ile 
                325                 330                 335     


Asp Phe Gly Ser Ala Ser His Val Ser Lys Ala Val Cys Ser Thr Tyr 
            340                 345                 350         


Leu Gln Ser Arg Tyr Tyr Arg Ala Pro Glu Ile Ile Leu Gly Leu Pro 
        355                 360                 365             


Phe Cys Glu Ala Ile Asp Met Trp Ser Leu Gly Cys Val Ile Ala Glu 
    370                 375                 380                 


Leu Phe Leu Gly Trp Pro Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gln 
385                 390                 395                 400 


Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu Pro Ala Glu Tyr Leu Leu 
                405                 410                 415     


Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe Asn Arg Asp Pro Asn Leu 
            420                 425                 430         


Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro Glu Glu His Glu Leu Glu 
        435                 440                 445             


Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys Tyr Ile Phe Asn Cys Leu 
    450                 455                 460                 


Asp Asp Met Ala Gln Val Asn Met Ser Thr Asp Leu Glu Gly Thr Asp 
465                 470                 475                 480 


Met Leu Ala Glu Lys Ala Asp Arg Arg Glu Tyr Ile Asp Leu Leu Lys 
                485                 490                 495     


Lys Met Leu Thr Ile Asp Ala Asp Lys Arg Ile Thr Pro Leu Lys Thr 
            500                 505                 510         


Leu Asn His Gln Phe Val Thr Met Thr His Leu Leu Asp Phe Pro His 
        515                 520                 525             


Ser Asn His Val Lys Ser Cys Phe Gln Asn Met Glu Ile Cys Lys Arg 
    530                 535                 540                 


Arg Val His Met Tyr Asp Thr Val Ser Gln Ile Lys Ser Pro Phe Thr 
545                 550                 555                 560 


Thr His Val Ala Pro Asn Thr Ser Thr Asn Leu Thr Met Ser Phe Ser 
                565                 570                 575     


Asn Gln Leu Asn Thr Val His Asn Gln Ala Ser Val Leu Ala Ser Ser 
            580                 585                 590         


Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu Ala Asn Ser Asp Val Ser 
        595                 600                 605             


Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro Ser Ser Ala Ala Pro Val 
    610                 615                 620                 


Pro Gly Val Ala Gln Gln Gly Val Ser Leu Gln Pro Gly Thr Thr Gln 
625                 630                 635                 640 


Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln Thr Phe Ile Val Cys Pro 
                645                 650                 655     


Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr Thr Lys His Ser Gly Phe 
            660                 665                 670         


Pro Val Arg Met Asp Asn Ala Val Pro Ile Val Pro Gln Ala Pro Ala 
        675                 680                 685             


Ala Gln Pro Leu Gln Ile Gln Ser Gly Val Leu Thr Gln Gln Ala Trp 
    690                 695                 700                 


Pro Gly Gly Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp Gln Gln Leu 
705                 710                 715                 720 


Pro Gly Val Ala Leu His Asn Ser Val Gln Pro Thr Ala Met Ile Pro 
                725                 730                 735     


Glu Ala Met Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg Asn Ala His 
            740                 745                 750         


Ser His Gly Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro Ser Leu Leu 
        755                 760                 765             


Thr Asn His Val Thr Leu Ala Thr Ala Gln Pro Leu Asn Val Gly Val 
    770                 775                 780                 


Ala His Val Val Arg Gln Gln Gln Ser Ser Ser Leu Pro Ser Lys Lys 
785                 790                 795                 800 


Asn Lys Gln Ser Ala Pro Val Ser Ser Lys Ser Ser Leu Asp Val Leu 
                805                 810                 815     


Pro Ser Gln Val Tyr Ser Leu Val Gly Ser Ser Pro Leu Arg Thr Thr 
            820                 825                 830         


Ser Ser Tyr Asn Ser Leu Val Pro Val Gln Asp Gln His Gln Pro Ile 
        835                 840                 845             


Ile Ile Pro Asp Thr Pro Ser Pro Pro Val Ser Val Ile Thr Ile Arg 
    850                 855                 860                 


Ser Asp Thr Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro Ser Ser Ser 
865                 870                 875                 880 


Gly Leu Lys Pro Arg Ser Asn Val Ile Ser Tyr Val Thr Val Asn Asp 
                885                 890                 895     


Ser Pro Asp Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser Thr Asp Thr 
            900                 905                 910         


Leu Ser Ala Leu Arg Gly Asn Ser Gly Ser Val Leu Glu Gly Pro Gly 
        915                 920                 925             


Arg Val Val Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile Val Pro Pro 
    930                 935                 940                 


Leu Lys Thr Gln Leu Gly Asp Cys Thr Val Ala Thr Gln Ala Ser Gly 
945                 950                 955                 960 


Leu Leu Ser Asn Lys Thr Lys Pro Val Ala Ser Val Ser Gly Gln Ser 
                965                 970                 975     


Ser Gly Cys Cys Ile Thr Pro Thr Gly Tyr Arg Ala Gln Arg Gly Gly 
            980                 985                 990         


Thr Ser Ala Ala Gln Pro Leu Asn  Leu Ser Gln Asn Gln  Gln Ser Ser 
        995                 1000                 1005             


Ala Ala  Pro Thr Ser Gln Glu  Arg Ser Ser Asn Pro  Ala Pro Arg 
    1010                 1015                 1020             


Arg Gln  Gln Ala Phe Val Ala  Pro Leu Ser Gln Ala  Pro Tyr Thr 
    1025                 1030                 1035             


Phe Gln  His Gly Ser Pro Leu  His Ser Thr Gly His  Pro His Leu 
    1040                 1045                 1050             


Ala Pro  Ala Pro Ala His Leu  Pro Ser Gln Ala His  Leu Tyr Thr 
    1055                 1060                 1065             


Tyr Ala  Ala Pro Thr Ser Ala  Ala Ala Leu Gly Ser  Thr Ser Ser 
    1070                 1075                 1080             


Ile Ala  His Leu Phe Ser Pro  Gln Gly Ser Ser Arg  His Ala Ala 
    1085                 1090                 1095             


Ala Tyr  Thr Thr His Pro Ser  Thr Leu Val His Gln  Val Pro Val 
    1100                 1105                 1110             


Ser Val  Gly Pro Ser Leu Leu  Thr Ser Ala Ser Val  Ala Pro Ala 
    1115                 1120                 1125             


Gln Tyr  Gln His Gln Phe Ala  Thr Gln Ser Tyr Ile  Gly Ser Ser 
    1130                 1135                 1140             


Arg Gly  Ser Thr Ile Tyr Thr  Gly Tyr Pro Leu Ser  Pro Thr Lys 
    1145                 1150                 1155             


Ile Ser  Gln Tyr Ser Tyr Leu  
    1160                 1165 


<210> 6223
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 6223
Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu Thr His Arg Ser Asn Val 
            100                 105                 110         


Ser Leu Leu Glu Pro Tyr Gln Lys Cys Gly Leu Lys Arg Lys Ser Glu 
        115                 120                 125             


Glu Val Asp Ser Asn Gly Ser Val Gln Ile Ile Glu Glu His Pro Pro 
    130                 135                 140                 


Leu Met Leu Gln Asn Arg Thr Val Val Gly Ala Ala Ala Thr Thr Thr 
145                 150                 155                 160 


Thr Val Thr Thr Lys Ser Ser Ser Ser Ser Gly Glu Gly Asp Tyr Gln 
                165                 170                 175     


Leu Val Gln His Glu Ile Leu Cys Ser Met Thr Asn Ser Tyr Glu Val 
            180                 185                 190         


Leu Glu Phe Leu Gly Arg Gly Thr Phe Gly Gln Val Ala Lys Cys Trp 
        195                 200                 205             


Lys Arg Ser Thr Lys Glu Ile Val Ala Ile Lys Ile Leu Lys Asn His 
    210                 215                 220                 


Pro Ser Tyr Ala Arg Gln Gly Gln Ile Glu Val Ser Ile Leu Ser Arg 
225                 230                 235                 240 


Leu Ser Ser Glu Asn Ala Asp Glu Tyr Asn Phe Val Arg Ser Tyr Glu 
                245                 250                 255     


Cys Phe Gln His Lys Asn His Thr Cys Leu Val Phe Glu Met Leu Glu 
            260                 265                 270         


Gln Asn Leu Tyr Asp Phe Leu Lys Gln Asn Lys Phe Ser Pro Leu Pro 
        275                 280                 285             


Leu Lys Tyr Ile Arg Pro Ile Leu Gln Gln Val Ala Thr Ala Leu Met 
    290                 295                 300                 


Lys Leu Lys Ser Leu Gly Leu Ile His Ala Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Met Leu Val Asp Pro Val Arg Gln Pro Tyr Arg Val Lys Val Ile 
                325                 330                 335     


Asp Phe Gly Ser Ala Ser His Val Ser Lys Ala Val Cys Ser Thr Tyr 
            340                 345                 350         


Leu Gln Ser Arg Tyr Tyr Arg Ala Pro Glu Ile Ile Leu Gly Leu Pro 
        355                 360                 365             


Phe Cys Glu Ala Ile Asp Met Trp Ser Leu Gly Cys Val Ile Ala Glu 
    370                 375                 380                 


Leu Phe Leu Gly Trp Pro Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gln 
385                 390                 395                 400 


Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu Pro Ala Glu Tyr Leu Leu 
                405                 410                 415     


Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe Asn Arg Asp Pro Asn Leu 
            420                 425                 430         


Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro Glu Glu His Glu Leu Glu 
        435                 440                 445             


Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys Tyr Ile Phe Asn Cys Leu 
    450                 455                 460                 


Asp Asp Met Ala Gln Val Asn Met Ser Thr Asp Leu Glu Gly Thr Asp 
465                 470                 475                 480 


Met Leu Ala Glu Lys Ala Asp Arg Arg Glu Tyr Ile Asp Leu Leu Lys 
                485                 490                 495     


Lys Met Leu Thr Ile Asp Ala Asp Lys Arg Ile Thr Pro Leu Lys Thr 
            500                 505                 510         


Leu Asn His Gln Phe Val Thr Met Thr His Leu Leu Asp Phe Pro His 
        515                 520                 525             


Ser Asn His Val Lys Ser Cys Phe Gln Asn Met Glu Ile Cys Lys Arg 
    530                 535                 540                 


Arg Val His Met Tyr Asp Thr Val Ser Gln Ile Lys Ser Pro Phe Thr 
545                 550                 555                 560 


Thr His Val Ala Pro Asn Thr Ser Thr Asn Leu Thr Met Ser Phe Ser 
                565                 570                 575     


Asn Gln Leu Asn Thr Val His Asn Gln Ala Ser Val Leu Ala Ser Ser 
            580                 585                 590         


Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu Ala Asn Ser Asp Val Ser 
        595                 600                 605             


Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro Ser Ser Ala Ala Pro Val 
    610                 615                 620                 


Pro Gly Val Ala Gln Gln Gly Val Ser Leu Gln Pro Gly Thr Thr Gln 
625                 630                 635                 640 


Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln Thr Phe Ile Val Cys Pro 
                645                 650                 655     


Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr Thr Lys His Ser Gly Phe 
            660                 665                 670         


Pro Val Arg Met Asp Asn Ala Val Pro Ile Val Pro Gln Ala Pro Ala 
        675                 680                 685             


Ala Gln Pro Leu Gln Ile Gln Ser Gly Val Leu Thr Gln Gly Ser Cys 
    690                 695                 700                 


Thr Pro Leu Met Val Ala Thr Leu His Pro Gln Val Ala Thr Ile Thr 
705                 710                 715                 720 


Pro Gln Tyr Ala Val Pro Phe Thr Leu Ser Cys Ala Ala Gly Arg Pro 
                725                 730                 735     


Ala Leu Val Glu Gln Thr Ala Ala Val Leu Gln Ala Trp Pro Gly Gly 
            740                 745                 750         


Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp Gln Gln Leu Pro Gly Val 
        755                 760                 765             


Ala Leu His Asn Ser Val Gln Pro Thr Ala Met Ile Pro Glu Ala Met 
    770                 775                 780                 


Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg Asn Ala His Ser His Gly 
785                 790                 795                 800 


Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro Ser Leu Leu Thr Asn His 
                805                 810                 815     


Val Thr Leu Ala Thr Ala Gln Pro Leu Asn Val Gly Val Ala His Val 
            820                 825                 830         


Val Arg Gln Gln Gln Ser Ser Ser Leu Pro Ser Lys Lys Asn Lys Gln 
        835                 840                 845             


Ser Ala Pro Val Ser Ser Lys Ser Ser Leu Asp Val Leu Pro Ser Gln 
    850                 855                 860                 


Val Tyr Ser Leu Val Gly Ser Ser Pro Leu Arg Thr Thr Ser Ser Tyr 
865                 870                 875                 880 


Asn Ser Leu Val Pro Val Gln Asp Gln His Gln Pro Ile Ile Ile Pro 
                885                 890                 895     


Asp Thr Pro Ser Pro Pro Val Ser Val Ile Thr Ile Arg Ser Asp Thr 
            900                 905                 910         


Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro Ser Ser Ser Gly Leu Lys 
        915                 920                 925             


Pro Arg Ser Asn Val Ile Ser Tyr Val Thr Val Asn Asp Ser Pro Asp 
    930                 935                 940                 


Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser Thr Asp Thr Leu Ser Ala 
945                 950                 955                 960 


Leu Arg Gly Asn Ser Gly Ser Val Leu Glu Gly Pro Gly Arg Val Val 
                965                 970                 975     


Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile Val Pro Pro Leu Lys Thr 
            980                 985                 990         


Gln Leu Gly Asp Cys Thr Val Ala  Thr Gln Ala Ser Gly  Leu Leu Ser 
        995                 1000                 1005             


Asn Lys  Thr Lys Pro Val Ala  Ser Val Ser Gly Gln  Ser Ser Gly 
    1010                 1015                 1020             


Cys Cys  Ile Thr Pro Thr Gly  Tyr Arg Ala Gln Arg  Gly Gly Thr 
    1025                 1030                 1035             


Ser Ala  Ala Gln Pro Leu Asn  Leu Ser Gln Asn Gln  Gln Ser Ser 
    1040                 1045                 1050             


Ala Ala  Pro Thr Ser Gln Glu  Arg Ser Ser Asn Pro  Ala Pro Arg 
    1055                 1060                 1065             


Arg Gln  Gln Ala Phe Val Ala  Pro Leu Ser Gln Ala  Pro Tyr Thr 
    1070                 1075                 1080             


Phe Gln  His Gly Ser Pro Leu  His Ser Thr Gly His  Pro His Leu 
    1085                 1090                 1095             


Ala Pro  Ala Pro Ala His Leu  Pro Ser Gln Ala His  Leu Tyr Thr 
    1100                 1105                 1110             


Tyr Ala  Ala Pro Thr Ser Ala  Ala Ala Leu Gly Ser  Thr Ser Ser 
    1115                 1120                 1125             


Ile Ala  His Leu Phe Ser Pro  Gln Gly Ser Ser Arg  His Ala Ala 
    1130                 1135                 1140             


Ala Tyr  Thr Thr His Pro Ser  Thr Leu Val His Gln  Val Pro Val 
    1145                 1150                 1155             


Ser Val  Gly Pro Ser Leu Leu  Thr Ser Ala Ser Val  Ala Pro Ala 
    1160                 1165                 1170             


Gln Tyr  Gln His Gln Phe Ala  Thr Gln Ser Tyr Ile  Gly Ser Ser 
    1175                 1180                 1185             


Arg Gly  Ser Thr Ile Tyr Thr  Gly Tyr Pro Leu Ser  Pro Thr Lys 
    1190                 1195                 1200             


Ile Ser  Gln Tyr Ser Tyr Leu  
    1205                 1210 


<210> 6224
<211> 1075
<212> PRT
<213> Homo sapiens

<400> 6224
Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu Thr His Arg Ser Asn Val 
            100                 105                 110         


Ser Leu Leu Glu Pro Tyr Gln Lys Cys Gly Leu Lys Arg Lys Ser Glu 
        115                 120                 125             


Glu Val Asp Ser Asn Gly Ser Val Gln Ile Ile Glu Glu His Pro Pro 
    130                 135                 140                 


Leu Met Leu Gln Asn Arg Thr Val Val Gly Ala Ala Ala Thr Thr Thr 
145                 150                 155                 160 


Thr Val Thr Thr Lys Ser Ser Ser Ser Ser Gly Glu Gly Asp Tyr Gln 
                165                 170                 175     


Leu Val Gln His Glu Ile Leu Cys Ser Met Thr Asn Ser Tyr Glu Val 
            180                 185                 190         


Leu Glu Phe Leu Gly Arg Gly Thr Phe Gly Gln Val Ala Lys Cys Trp 
        195                 200                 205             


Lys Arg Ser Thr Lys Glu Ile Val Ala Ile Lys Ile Leu Lys Asn His 
    210                 215                 220                 


Pro Ser Tyr Ala Arg Gln Gly Gln Ile Glu Val Ser Ile Leu Ser Arg 
225                 230                 235                 240 


Leu Ser Ser Glu Asn Ala Asp Glu Tyr Asn Phe Val Arg Ser Tyr Glu 
                245                 250                 255     


Cys Phe Gln His Lys Asn His Thr Cys Leu Val Phe Glu Met Leu Glu 
            260                 265                 270         


Gln Asn Leu Tyr Asp Phe Leu Lys Gln Asn Lys Phe Ser Pro Leu Pro 
        275                 280                 285             


Leu Lys Tyr Ile Arg Pro Ile Leu Gln Gln Val Ala Thr Ala Leu Met 
    290                 295                 300                 


Lys Leu Lys Ser Leu Gly Leu Ile His Ala Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Met Leu Val Asp Pro Val Arg Gln Pro Tyr Arg Val Lys Val Ile 
                325                 330                 335     


Asp Phe Gly Ser Ala Ser His Val Ser Lys Ala Val Cys Ser Thr Tyr 
            340                 345                 350         


Leu Gln Ser Arg Tyr Tyr Arg Ala Pro Glu Ile Ile Leu Gly Leu Pro 
        355                 360                 365             


Phe Cys Glu Ala Ile Asp Met Trp Ser Leu Gly Cys Val Ile Ala Glu 
    370                 375                 380                 


Leu Phe Leu Gly Trp Pro Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gln 
385                 390                 395                 400 


Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu Pro Ala Glu Tyr Leu Leu 
                405                 410                 415     


Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe Asn Arg Asp Pro Asn Leu 
            420                 425                 430         


Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro Glu Glu His Glu Leu Glu 
        435                 440                 445             


Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys Tyr Ile Phe Asn Cys Leu 
    450                 455                 460                 


Asp Asp Met Ala Gln Val Asn Met Ser Thr Asp Leu Glu Gly Thr Asp 
465                 470                 475                 480 


Met Leu Ala Glu Lys Ala Asp Arg Arg Glu Tyr Ile Asp Leu Leu Lys 
                485                 490                 495     


Lys Met Leu Thr Ile Asp Ala Asp Lys Arg Ile Thr Pro Leu Lys Thr 
            500                 505                 510         


Leu Asn His Gln Phe Val Thr Met Thr His Leu Leu Asp Phe Pro His 
        515                 520                 525             


Ser Asn His Val Lys Ser Cys Phe Gln Asn Met Glu Ile Cys Lys Arg 
    530                 535                 540                 


Arg Val His Met Tyr Asp Thr Val Ser Gln Ile Lys Ser Pro Phe Thr 
545                 550                 555                 560 


Thr His Val Ala Pro Asn Thr Ser Thr Asn Leu Thr Met Ser Phe Ser 
                565                 570                 575     


Asn Gln Leu Asn Thr Val His Asn Gln Ala Ser Val Leu Ala Ser Ser 
            580                 585                 590         


Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu Ala Asn Ser Asp Val Ser 
        595                 600                 605             


Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro Ser Ser Ala Ala Pro Val 
    610                 615                 620                 


Pro Gly Val Ala Gln Gln Gly Val Ser Leu Gln Pro Gly Thr Thr Gln 
625                 630                 635                 640 


Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln Thr Phe Ile Val Cys Pro 
                645                 650                 655     


Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr Thr Lys His Ser Gly Phe 
            660                 665                 670         


Pro Val Arg Met Asp Asn Ala Val Pro Ile Val Pro Gln Ala Pro Ala 
        675                 680                 685             


Ala Gln Pro Leu Gln Ile Gln Ser Gly Val Leu Thr Gln Gly Ser Cys 
    690                 695                 700                 


Thr Pro Leu Met Val Ala Thr Leu His Pro Gln Val Ala Thr Ile Thr 
705                 710                 715                 720 


Pro Gln Tyr Ala Val Pro Phe Thr Leu Ser Cys Ala Ala Gly Arg Pro 
                725                 730                 735     


Ala Leu Val Glu Gln Thr Ala Ala Val Leu Gln Ala Trp Pro Gly Gly 
            740                 745                 750         


Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp Gln Gln Leu Pro Gly Val 
        755                 760                 765             


Ala Leu His Asn Ser Val Gln Pro Thr Ala Met Ile Pro Glu Ala Met 
    770                 775                 780                 


Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg Asn Ala His Ser His Gly 
785                 790                 795                 800 


Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro Ser Leu Leu Thr Asn His 
                805                 810                 815     


Val Thr Leu Ala Thr Ala Gln Pro Leu Asn Val Gly Val Ala His Val 
            820                 825                 830         


Val Arg Gln Gln Gln Ser Ser Ser Leu Pro Ser Lys Lys Asn Lys Gln 
        835                 840                 845             


Ser Ala Pro Val Ser Ser Lys Ser Ser Leu Asp Val Leu Pro Ser Gln 
    850                 855                 860                 


Val Tyr Ser Leu Val Gly Ser Ser Pro Leu Arg Thr Thr Ser Ser Tyr 
865                 870                 875                 880 


Asn Ser Leu Val Pro Val Gln Asp Gln His Gln Pro Ile Ile Ile Pro 
                885                 890                 895     


Asp Thr Pro Ser Pro Pro Val Ser Val Ile Thr Ile Arg Ser Asp Thr 
            900                 905                 910         


Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro Ser Ser Ser Gly Leu Lys 
        915                 920                 925             


Pro Arg Ser Asn Val Ile Ser Tyr Val Thr Val Asn Asp Ser Pro Asp 
    930                 935                 940                 


Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser Thr Asp Thr Leu Ser Ala 
945                 950                 955                 960 


Leu Arg Gly Asn Ser Gly Ser Val Leu Glu Gly Pro Gly Arg Val Val 
                965                 970                 975     


Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile Val Pro Pro Leu Lys Thr 
            980                 985                 990         


Gln Leu Gly Asp Cys Thr Val Ala  Thr Gln Ala Ser Gly  Leu Leu Ser 
        995                 1000                 1005             


Asn Lys  Thr Lys Pro Val Ala  Ser Val Ser Gly Gln  Ser Ser Gly 
    1010                 1015                 1020             


Cys Cys  Ile Thr Pro Thr Gly  Tyr Arg Ala Gln Arg  Gly Gly Thr 
    1025                 1030                 1035             


Ser Ala  Ala Gln Pro Leu Asn  Leu Ser Gln Val Ser  Ala Met Gly 
    1040                 1045                 1050             


Tyr Cys  Leu Leu Phe Gly Pro  Cys Thr Val Val Thr  Phe Trp Arg 
    1055                 1060                 1065             


Thr Leu  Leu Leu Ala Gly Cys  
    1070                 1075 


<210> 6225
<211> 180
<212> PRT
<213> Homo sapiens

<400> 6225
Met Gln Ala Glu Gly Gln Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Gln Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Ala Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210> 6226
<211> 238
<212> PRT
<213> Homo sapiens

<400> 6226
Met Ser Glu Asp Leu Ala Lys Gln Leu Ala Ser Tyr Lys Ala Gln Leu 
1               5                   10                  15      


Gln Gln Val Glu Ala Ala Leu Ser Gly Asn Gly Glu Asn Glu Asp Leu 
            20                  25                  30          


Leu Lys Leu Lys Lys Asp Leu Gln Glu Val Ile Glu Leu Thr Lys Asp 
        35                  40                  45              


Leu Leu Ser Thr Gln Pro Ser Glu Thr Leu Ala Ser Ser Asp Ser Phe 
    50                  55                  60                  


Ala Ser Thr Gln Pro Thr His Ser Trp Lys Val Gly Asp Lys Cys Met 
65                  70                  75                  80  


Ala Val Trp Ser Glu Asp Gly Gln Cys Tyr Glu Ala Glu Ile Glu Glu 
                85                  90                  95      


Ile Asp Glu Glu Asn Gly Thr Ala Ala Ile Thr Phe Ala Gly Tyr Gly 
            100                 105                 110         


Asn Ala Glu Val Thr Pro Leu Leu Asn Leu Lys Pro Val Glu Glu Gly 
        115                 120                 125             


Arg Lys Ala Lys Glu Asp Ser Gly Asn Lys Pro Met Ser Lys Lys Glu 
    130                 135                 140                 


Met Ile Ala Gln Gln Arg Glu Tyr Lys Lys Lys Lys Ala Leu Lys Lys 
145                 150                 155                 160 


Ala Gln Arg Ile Lys Glu Leu Glu Gln Glu Arg Glu Asp Gln Lys Val 
                165                 170                 175     


Lys Trp Gln Gln Phe Asn Asn Arg Ala Tyr Ser Lys Asn Lys Lys Gly 
            180                 185                 190         


Gln Val Lys Arg Ser Ile Phe Ala Ser Pro Glu Ser Val Thr Gly Lys 
        195                 200                 205             


Val Gly Val Gly Thr Cys Gly Ile Ala Asp Lys Pro Met Thr Gln Tyr 
    210                 215                 220                 


Gln Asp Thr Ser Lys Tyr Asn Val Arg His Leu Met Pro Gln 
225                 230                 235             


<210> 6227
<211> 238
<212> PRT
<213> Homo sapiens

<400> 6227
Met Ser Glu Asp Leu Ala Lys Gln Leu Ala Ser Tyr Lys Ala Gln Leu 
1               5                   10                  15      


Gln Gln Val Glu Ala Ala Leu Ser Gly Asn Gly Glu Asn Glu Asp Leu 
            20                  25                  30          


Leu Lys Leu Lys Lys Asp Leu Gln Glu Val Ile Glu Leu Thr Lys Asp 
        35                  40                  45              


Leu Leu Ser Thr Gln Pro Ser Glu Thr Leu Ala Ser Ser Asp Ser Phe 
    50                  55                  60                  


Ala Ser Thr Gln Pro Thr His Ser Trp Lys Val Gly Asp Lys Cys Met 
65                  70                  75                  80  


Ala Val Trp Ser Glu Asp Gly Gln Cys Tyr Glu Ala Glu Ile Glu Glu 
                85                  90                  95      


Ile Asp Glu Glu Asn Gly Thr Ala Ala Ile Thr Phe Ala Gly Tyr Gly 
            100                 105                 110         


Asn Ala Glu Val Thr Pro Leu Leu Asn Leu Lys Pro Val Glu Glu Gly 
        115                 120                 125             


Arg Lys Ala Lys Glu Asp Ser Gly Asn Lys Pro Met Ser Lys Lys Glu 
    130                 135                 140                 


Met Ile Ala Gln Gln Arg Glu Tyr Lys Lys Lys Lys Ala Leu Lys Lys 
145                 150                 155                 160 


Ala Gln Arg Ile Lys Glu Leu Glu Gln Glu Arg Glu Asp Gln Lys Val 
                165                 170                 175     


Lys Trp Gln Gln Phe Asn Asn Arg Ala Tyr Ser Lys Asn Lys Lys Gly 
            180                 185                 190         


Gln Val Lys Arg Ser Ile Phe Ala Ser Pro Glu Ser Val Thr Gly Lys 
        195                 200                 205             


Val Gly Val Gly Thr Cys Gly Ile Ala Asp Lys Pro Met Thr Gln Tyr 
    210                 215                 220                 


Gln Asp Thr Ser Lys Tyr Asn Val Arg His Leu Met Pro Gln 
225                 230                 235             


<210> 6228
<211> 742
<212> PRT
<213> Homo sapiens

<400> 6228
Asp Leu Ser Ser Gly Gly Gly Ile Glu Pro Gln Cys Ser Ser Glu Val 
1               5                   10                  15      


Tyr Phe Arg Ala Arg Glu Arg Gly Cys Glu Asn Val Ala Trp Ser Leu 
            20                  25                  30          


Gly Leu Arg Ser His Cys Phe Leu Glu Ala Glu Leu His Pro Leu Pro 
        35                  40                  45              


Trp Phe Leu Pro Thr Asn Val Cys Ser Pro Leu Pro Gly Ala Ala His 
    50                  55                  60                  


Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala His Ser Arg Pro Gly Pro 
65                  70                  75                  80  


Ala Ser Ile Leu Pro His Asp Leu Asp Pro Phe Leu Cys Thr His Leu 
                85                  90                  95      


Ile Phe Ala Phe Ala Ser Met Asn Asn Asn Gln Ile Val Ala Lys Asp 
            100                 105                 110         


Leu Gln Asp Glu Lys Ile Leu Tyr Pro Glu Phe Asn Lys Leu Lys Glu 
        115                 120                 125             


Arg Met Trp Gln Gln Leu Pro Thr Gly Val Lys Asn Pro Ala His Gln 
    130                 135                 140                 


Pro Ser Leu Ser His His Arg Asn Arg Glu Leu Lys Thr Leu Leu Ser 
145                 150                 155                 160 


Ile Gly Gly Trp Asn Phe Gly Thr Ser Arg Phe Thr Thr Met Leu Ser 
                165                 170                 175     


Thr Phe Ala Asn Arg Glu Lys Phe Ile Ala Ser Val Ile Ser Leu Leu 
            180                 185                 190         


Arg Thr His Asp Phe Asp Gly Leu Asp Leu Phe Phe Leu Tyr Pro Gly 
        195                 200                 205             


Leu Arg Gly Ser Pro Met His Asp Arg Trp Thr Phe Leu Phe Leu Ile 
    210                 215                 220                 


Glu Glu Leu Leu Phe Ala Phe Arg Lys Glu Ala Leu Leu Thr Met Arg 
225                 230                 235                 240 


Pro Arg Leu Leu Leu Ser Ala Ala Val Ser Gly Val Pro His Ile Val 
                245                 250                 255     


Gln Thr Ser Tyr Asp Val Arg Phe Leu Gly Arg Leu Leu Asp Phe Ile 
            260                 265                 270         


Asn Val Leu Ser Tyr Asp Leu His Gly Ser Trp Glu Arg Phe Thr Gly 
        275                 280                 285             


His Asn Ser Pro Leu Phe Ser Leu Pro Glu Asp Pro Lys Ser Ser Ala 
    290                 295                 300                 


Tyr Ala Met Asn Tyr Trp Arg Lys Leu Gly Ala Pro Ser Glu Lys Leu 
305                 310                 315                 320 


Ile Met Gly Ile Pro Thr Tyr Gly Arg Thr Phe Arg Leu Leu Lys Ala 
                325                 330                 335     


Ser Lys Asn Gly Leu Gln Ala Arg Ala Ile Gly Pro Ala Ser Pro Gly 
            340                 345                 350         


Lys Tyr Thr Lys Gln Glu Gly Phe Leu Ala Tyr Phe Glu Ile Cys Ser 
        355                 360                 365             


Phe Val Trp Gly Ala Lys Lys His Trp Ile Asp Tyr Gln Tyr Val Pro 
    370                 375                 380                 


Tyr Ala Asn Lys Gly Lys Glu Trp Val Gly Tyr Asp Asn Ala Ile Ser 
385                 390                 395                 400 


Phe Ser Tyr Lys Ala Trp Phe Ile Arg Arg Glu His Phe Gly Gly Ala 
                405                 410                 415     


Met Val Trp Thr Leu Asp Met Asp Asp Val Arg Gly Thr Phe Cys Gly 
            420                 425                 430         


Thr Gly Pro Phe Pro Leu Val Tyr Val Leu Asn Asp Ile Leu Val Arg 
        435                 440                 445             


Ala Glu Phe Ser Ser Thr Ser Leu Pro Gln Phe Trp Leu Ser Ser Ala 
    450                 455                 460                 


Val Asn Ser Ser Ser Thr Asp Pro Glu Arg Leu Ala Val Thr Thr Ala 
465                 470                 475                 480 


Trp Thr Thr Asp Ser Lys Ile Leu Pro Pro Gly Gly Glu Ala Gly Val 
                485                 490                 495     


Thr Glu Ile His Gly Lys Cys Glu Asn Met Thr Ile Thr Pro Arg Gly 
            500                 505                 510         


Thr Thr Val Thr Pro Thr Lys Glu Thr Val Ser Leu Gly Lys His Thr 
        515                 520                 525             


Val Ala Leu Gly Glu Lys Thr Glu Ile Thr Gly Ala Met Thr Met Thr 
    530                 535                 540                 


Ser Val Gly His Gln Ser Met Thr Pro Gly Glu Lys Ala Leu Thr Pro 
545                 550                 555                 560 


Val Gly His Gln Ser Val Thr Thr Gly Gln Lys Thr Leu Thr Ser Val 
                565                 570                 575     


Gly Tyr Gln Ser Val Thr Pro Gly Glu Lys Thr Leu Thr Pro Val Gly 
            580                 585                 590         


His Gln Ser Val Thr Pro Val Ser His Gln Ser Val Ser Pro Gly Gly 
        595                 600                 605             


Thr Thr Met Thr Pro Val His Phe Gln Thr Glu Thr Leu Arg Gln Asn 
    610                 615                 620                 


Thr Val Ala Pro Arg Arg Lys Ala Val Ala Arg Glu Lys Val Thr Val 
625                 630                 635                 640 


Pro Ser Arg Asn Ile Ser Val Thr Pro Glu Gly Gln Thr Met Pro Leu 
                645                 650                 655     


Arg Gly Glu Asn Leu Thr Ser Glu Val Gly Thr His Pro Arg Met Gly 
            660                 665                 670         


Asn Leu Gly Leu Gln Met Glu Ala Glu Asn Arg Met Met Leu Ser Ser 
        675                 680                 685             


Ser Pro Val Ile Gln Leu Pro Glu Gln Thr Pro Leu Ala Phe Asp Asn 
    690                 695                 700                 


Arg Phe Val Pro Ile Tyr Gly Asn His Ser Ser Val Asn Ser Val Thr 
705                 710                 715                 720 


Pro Gln Thr Ser Pro Leu Ser Leu Lys Lys Glu Ile Pro Glu Asn Ser 
                725                 730                 735     


Ala Val Asp Glu Glu Ala 
            740         


<210> 6229
<211> 678
<212> PRT
<213> Homo sapiens

<400> 6229
Met Trp Lys Leu Leu Leu Trp Val Gly Leu Val Leu Val Leu Lys His 
1               5                   10                  15      


His Asp Gly Ala Ala His Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


His Ser Arg Pro Gly Pro Ala Ser Ile Leu Pro His Asp Leu Asp Pro 
        35                  40                  45              


Phe Leu Cys Thr His Leu Ile Phe Ala Phe Ala Ser Met Asn Asn Asn 
    50                  55                  60                  


Gln Ile Val Ala Lys Asp Leu Gln Asp Glu Lys Ile Leu Tyr Pro Glu 
65                  70                  75                  80  


Phe Asn Lys Leu Lys Glu Arg Asn Arg Glu Leu Lys Thr Leu Leu Ser 
                85                  90                  95      


Ile Gly Gly Trp Asn Phe Gly Thr Ser Arg Phe Thr Thr Met Leu Ser 
            100                 105                 110         


Thr Phe Ala Asn Arg Glu Lys Phe Ile Ala Ser Val Ile Ser Leu Leu 
        115                 120                 125             


Arg Thr His Asp Phe Asp Gly Leu Asp Leu Phe Phe Leu Tyr Pro Gly 
    130                 135                 140                 


Leu Arg Gly Ser Pro Met His Asp Arg Trp Thr Phe Leu Phe Leu Ile 
145                 150                 155                 160 


Glu Glu Leu Leu Phe Ala Phe Arg Lys Glu Ala Leu Leu Thr Met Arg 
                165                 170                 175     


Pro Arg Leu Leu Leu Ser Ala Ala Val Ser Gly Val Pro His Ile Val 
            180                 185                 190         


Gln Thr Ser Tyr Asp Val Arg Phe Leu Gly Arg Leu Leu Asp Phe Ile 
        195                 200                 205             


Asn Val Leu Ser Tyr Asp Leu His Gly Ser Trp Glu Arg Phe Thr Gly 
    210                 215                 220                 


His Asn Ser Pro Leu Phe Ser Leu Pro Glu Asp Pro Lys Ser Ser Ala 
225                 230                 235                 240 


Tyr Ala Met Asn Tyr Trp Arg Lys Leu Gly Ala Pro Ser Glu Lys Leu 
                245                 250                 255     


Ile Met Gly Ile Pro Thr Tyr Gly Arg Thr Phe Arg Leu Leu Lys Ala 
            260                 265                 270         


Ser Lys Asn Gly Leu Gln Ala Arg Ala Ile Gly Pro Ala Ser Pro Gly 
        275                 280                 285             


Lys Tyr Thr Lys Gln Glu Gly Phe Leu Ala Tyr Phe Glu Ile Cys Ser 
    290                 295                 300                 


Phe Val Trp Gly Ala Lys Lys His Trp Ile Asp Tyr Gln Tyr Val Pro 
305                 310                 315                 320 


Tyr Ala Asn Lys Gly Lys Glu Trp Val Gly Tyr Asp Asn Ala Ile Ser 
                325                 330                 335     


Phe Ser Tyr Lys Ala Trp Phe Ile Arg Arg Glu His Phe Gly Gly Ala 
            340                 345                 350         


Met Val Trp Thr Leu Asp Met Asp Asp Val Arg Gly Thr Phe Cys Gly 
        355                 360                 365             


Thr Gly Pro Phe Pro Leu Val Tyr Val Leu Asn Asp Ile Leu Val Arg 
    370                 375                 380                 


Ala Glu Phe Ser Ser Thr Ser Leu Pro Gln Phe Trp Leu Ser Ser Ala 
385                 390                 395                 400 


Val Asn Ser Ser Ser Thr Asp Pro Glu Arg Leu Ala Val Thr Thr Ala 
                405                 410                 415     


Trp Thr Thr Asp Ser Lys Ile Leu Pro Pro Gly Gly Glu Ala Gly Val 
            420                 425                 430         


Thr Glu Ile His Gly Lys Cys Glu Asn Met Thr Ile Thr Pro Arg Gly 
        435                 440                 445             


Thr Thr Val Thr Pro Thr Lys Glu Thr Val Ser Leu Gly Lys His Thr 
    450                 455                 460                 


Val Ala Leu Gly Glu Lys Thr Glu Ile Thr Gly Ala Met Thr Met Thr 
465                 470                 475                 480 


Ser Val Gly His Gln Ser Met Thr Pro Gly Glu Lys Ala Leu Thr Pro 
                485                 490                 495     


Val Gly His Gln Ser Val Thr Thr Gly Gln Lys Thr Leu Thr Ser Val 
            500                 505                 510         


Gly Tyr Gln Ser Val Thr Pro Gly Glu Lys Thr Leu Thr Pro Val Gly 
        515                 520                 525             


His Gln Ser Val Thr Pro Val Ser His Gln Ser Val Ser Pro Gly Gly 
    530                 535                 540                 


Thr Thr Met Thr Pro Val His Phe Gln Thr Glu Thr Leu Arg Gln Asn 
545                 550                 555                 560 


Thr Val Ala Pro Arg Arg Lys Ala Val Ala Arg Glu Lys Val Thr Val 
                565                 570                 575     


Pro Ser Arg Asn Ile Ser Val Thr Pro Glu Gly Gln Thr Met Pro Leu 
            580                 585                 590         


Arg Gly Glu Asn Leu Thr Ser Glu Val Gly Thr His Pro Arg Met Gly 
        595                 600                 605             


Asn Leu Gly Leu Gln Met Glu Ala Glu Asn Arg Met Met Leu Ser Ser 
    610                 615                 620                 


Ser Pro Val Ile Gln Leu Pro Glu Gln Thr Pro Leu Ala Phe Asp Asn 
625                 630                 635                 640 


Arg Phe Val Pro Ile Tyr Gly Asn His Ser Ser Val Asn Ser Val Thr 
                645                 650                 655     


Pro Gln Thr Ser Pro Leu Ser Leu Lys Lys Glu Ile Pro Glu Asn Ser 
            660                 665                 670         


Ala Val Asp Glu Glu Ala 
        675             


<210> 6230
<211> 334
<212> PRT
<213> Homo sapiens

<400> 6230
Met Gly Gly Ala Val Ser Ala Gly Glu Asp Asn Asp Glu Leu Ile Asp 
1               5                   10                  15      


Asn Leu Lys Glu Ala Gln Tyr Ile Arg Thr Glu Leu Val Glu Gln Ala 
            20                  25                  30          


Phe Arg Ala Ile Asp Arg Ala Asp Tyr Tyr Leu Glu Glu Phe Lys Glu 
        35                  40                  45              


Asn Ala Tyr Lys Asp Leu Ala Trp Lys His Gly Asn Ile His Leu Ser 
    50                  55                  60                  


Ala Pro Cys Ile Tyr Ser Glu Val Met Glu Ala Leu Asp Leu Gln Pro 
65                  70                  75                  80  


Gly Leu Ser Phe Leu Asn Leu Gly Ser Gly Thr Gly Tyr Leu Ser Ser 
                85                  90                  95      


Met Val Gly Leu Ile Leu Gly Pro Phe Gly Val Asn His Gly Val Glu 
            100                 105                 110         


Leu His Ser Asp Val Ile Glu Tyr Ala Lys Gln Lys Leu Asp Phe Phe 
        115                 120                 125             


Ile Arg Thr Ser Asp Ser Phe Asp Lys Phe Asp Phe Cys Glu Pro Ser 
    130                 135                 140                 


Phe Val Thr Gly Asn Cys Leu Glu Ile Ser Pro Asp Cys Ser Gln Tyr 
145                 150                 155                 160 


Asp Arg Val Tyr Cys Gly Ala Gly Val Gln Lys Glu His Glu Glu Tyr 
                165                 170                 175     


Met Lys Asn Leu Leu Lys Val Gly Gly Ile Leu Val Met Pro Leu Glu 
            180                 185                 190         


Glu Lys Pro Cys His Ser Glu Ser Gly Lys Ser Arg Leu Val Gln Leu 
        195                 200                 205             


Pro Pro Val Ala Val Arg Ser Leu Gln Asp Leu Ala Arg Ile Ala Ile 
    210                 215                 220                 


Arg Gly Thr Ile Lys Lys Ile Ile His Gln Glu Thr Val Ser Lys Asn 
225                 230                 235                 240 


Gly Asn Gly Leu Lys Asn Thr Pro Arg Phe Lys Arg Arg Arg Val Arg 
                245                 250                 255     


Arg Arg Arg Met Glu Thr Ile Val Phe Leu Asp Lys Glu Val Phe Ala 
            260                 265                 270         


Ser Arg Ile Ser Asn Pro Ser Asp Asp Asn Ser Cys Glu Asp Leu Glu 
        275                 280                 285             


Glu Glu Arg Arg Glu Glu Glu Glu Lys Thr Pro Pro Glu Thr Lys Pro 
    290                 295                 300                 


Asp Pro Pro Val Asn Phe Leu Arg Gln Lys Val Leu Ser Leu Pro Leu 
305                 310                 315                 320 


Pro Asp Pro Leu Lys Tyr Tyr Leu Leu Tyr Tyr Arg Glu Lys 
                325                 330                 


<210> 6231
<211> 594
<212> PRT
<213> Homo sapiens

<400> 6231
Met Ser Arg Pro Ser Ser Arg Ala Ile Tyr Leu His Arg Lys Glu Tyr 
1               5                   10                  15      


Ser Gln Asn Leu Thr Ser Glu Pro Thr Leu Leu Gln His Arg Val Glu 
            20                  25                  30          


His Leu Met Thr Cys Lys Gln Gly Ser Gln Arg Val Gln Gly Pro Glu 
        35                  40                  45              


Asp Ala Leu Gln Lys Leu Phe Glu Met Asp Ala Gln Gly Arg Val Trp 
    50                  55                  60                  


Ser Gln Asp Leu Ile Leu Gln Val Arg Asp Gly Trp Leu Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Glu Thr Lys Glu Glu Leu Asp Ser Tyr Arg Leu Asp Ser Ile 
                85                  90                  95      


Gln Ala Met Asn Val Ala Leu Asn Thr Cys Ser Tyr Asn Ser Ile Leu 
            100                 105                 110         


Ser Ile Thr Val Gln Glu Pro Gly Leu Pro Gly Thr Ser Thr Leu Leu 
        115                 120                 125             


Phe Gln Cys Gln Glu Val Gly Ala Glu Arg Leu Lys Thr Ser Leu Gln 
    130                 135                 140                 


Lys Ala Leu Glu Glu Glu Leu Glu Gln Ser Arg Pro Arg Leu Gly Gly 
145                 150                 155                 160 


Leu Gln Pro Gly Gln Asp Arg Trp Arg Gly Pro Ala Met Glu Arg Pro 
                165                 170                 175     


Leu Pro Met Glu Gln Ala Arg Tyr Leu Glu Pro Gly Ile Pro Pro Glu 
            180                 185                 190         


Gln Pro His Gln Arg Thr Leu Glu His Ser Leu Pro Pro Ser Pro Arg 
        195                 200                 205             


Pro Leu Pro Arg His Thr Ser Ala Arg Glu Pro Ser Ala Phe Thr Leu 
    210                 215                 220                 


Pro Pro Pro Arg Arg Ser Ser Ser Pro Glu Asp Pro Glu Arg Asp Glu 
225                 230                 235                 240 


Glu Val Leu Asn His Val Leu Arg Asp Ile Glu Leu Phe Met Gly Lys 
                245                 250                 255     


Leu Glu Lys Ala Gln Ala Lys Thr Ser Arg Lys Lys Lys Phe Gly Lys 
            260                 265                 270         


Lys Asn Lys Asp Gln Gly Gly Leu Thr Gln Ala Gln Tyr Ile Asp Cys 
        275                 280                 285             


Phe Gln Lys Ile Lys His Ser Phe Asn Leu Leu Gly Arg Leu Ala Thr 
    290                 295                 300                 


Trp Leu Lys Glu Thr Ser Ala Pro Glu Leu Val His Ile Leu Phe Lys 
305                 310                 315                 320 


Ser Leu Asn Phe Ile Leu Ala Arg Cys Pro Glu Ala Gly Leu Ala Ala 
                325                 330                 335     


Gln Val Ile Ser Pro Leu Leu Thr Pro Lys Ala Ile Asn Leu Leu Gln 
            340                 345                 350         


Ser Cys Leu Ser Pro Pro Glu Ser Asn Leu Trp Met Gly Leu Gly Pro 
        355                 360                 365             


Ala Trp Thr Thr Ser Arg Ala Asp Trp Thr Gly Asp Glu Pro Leu Pro 
    370                 375                 380                 


Tyr Gln Pro Thr Phe Ser Asp Asp Trp Gln Leu Pro Glu Pro Ser Ser 
385                 390                 395                 400 


Gln Ala Pro Leu Gly Tyr Gln Asp Pro Val Ser Leu Arg Arg Gly Ser 
                405                 410                 415     


His Arg Leu Gly Ser Thr Ser His Phe Pro Gln Glu Lys Thr His Asn 
            420                 425                 430         


His Asp Pro Gln Pro Gly Asp Pro Asn Ser Arg Pro Ser Ser Pro Lys 
        435                 440                 445             


Pro Ala Gln Pro Ala Leu Lys Met Gln Val Leu Tyr Glu Phe Glu Ala 
    450                 455                 460                 


Arg Asn Pro Arg Glu Leu Thr Val Val Gln Gly Glu Lys Leu Glu Val 
465                 470                 475                 480 


Leu Asp His Ser Lys Arg Trp Trp Leu Val Lys Asn Glu Ala Gly Arg 
                485                 490                 495     


Ser Gly Tyr Ile Pro Ser Asn Ile Leu Glu Pro Leu Gln Pro Gly Thr 
            500                 505                 510         


Pro Gly Thr Gln Gly Gln Ser Pro Ser Arg Val Pro Met Leu Arg Leu 
        515                 520                 525             


Ser Ser Arg Pro Glu Glu Val Thr Asp Trp Leu Gln Ala Glu Asn Phe 
    530                 535                 540                 


Ser Thr Ala Thr Val Arg Thr Leu Gly Ser Leu Thr Gly Ser Gln Leu 
545                 550                 555                 560 


Leu Arg Ile Arg Pro Gly Glu Leu Gln Met Leu Cys Pro Gln Glu Ala 
                565                 570                 575     


Pro Arg Ile Leu Ser Arg Leu Glu Ala Val Arg Arg Met Leu Gly Ile 
            580                 585                 590         


Ser Pro 
        


<210> 6232
<211> 499
<212> PRT
<213> Homo sapiens

<400> 6232
Met Ser Phe Gly Ser Glu His Tyr Leu Cys Ser Ser Ser Ser Tyr Arg 
1               5                   10                  15      


Lys Val Phe Gly Asp Gly Ser Arg Leu Ser Ala Arg Leu Ser Gly Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Phe Arg Ser Gln Ser Leu Ser Arg Ser Asn Val 
        35                  40                  45              


Ala Ser Ser Ala Ala Cys Ser Ser Ala Ser Ser Leu Gly Leu Gly Leu 
    50                  55                  60                  


Ala Tyr Arg Arg Pro Pro Ala Ser Asp Gly Leu Asp Leu Ser Gln Ala 
65                  70                  75                  80  


Ala Ala Arg Thr Asn Glu Tyr Lys Ile Ile Arg Thr Asn Glu Lys Glu 
                85                  90                  95      


Gln Leu Gln Gly Leu Asn Asp Arg Phe Ala Val Phe Ile Glu Lys Val 
            100                 105                 110         


His Gln Leu Glu Thr Gln Asn Arg Ala Leu Glu Ala Glu Leu Ala Ala 
        115                 120                 125             


Leu Arg Gln Arg His Ala Glu Pro Ser Arg Val Gly Glu Leu Phe Gln 
    130                 135                 140                 


Arg Glu Leu Arg Asp Leu Arg Ala Gln Leu Glu Glu Ala Ser Ser Ala 
145                 150                 155                 160 


Arg Ser Gln Ala Leu Leu Glu Arg Asp Gly Leu Ala Glu Glu Val Gln 
                165                 170                 175     


Arg Leu Arg Ala Arg Cys Glu Glu Glu Ser Arg Gly Arg Glu Gly Ala 
            180                 185                 190         


Glu Arg Ala Leu Lys Ala Gln Gln Arg Asp Val Asp Gly Ala Thr Leu 
        195                 200                 205             


Ala Arg Leu Asp Leu Glu Lys Lys Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Ala Phe Val Arg Gln Val His Asp Glu Glu Val Ala Glu Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Gln Ala Ser Ser Gln Ala Ala Ala Glu Val Asp Val Thr Val 
                245                 250                 255     


Ala Lys Pro Asp Leu Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Tyr 
            260                 265                 270         


Glu Ser Leu Ala Ala Lys Asn Leu Gln Ser Ala Glu Glu Trp Tyr Lys 
        275                 280                 285             


Ser Lys Phe Ala Asn Leu Asn Glu Gln Ala Ala Arg Ser Thr Glu Ala 
    290                 295                 300                 


Ile Arg Ala Ser Arg Glu Glu Ile His Glu Tyr Arg Arg Gln Leu Gln 
305                 310                 315                 320 


Ala Arg Thr Ile Glu Ile Glu Gly Leu Arg Gly Ala Asn Glu Ser Leu 
                325                 330                 335     


Glu Arg Gln Ile Leu Glu Leu Glu Glu Arg His Ser Ala Glu Val Ala 
            340                 345                 350         


Gly Tyr Gln Asp Ser Ile Gly Gln Leu Glu Asn Asp Leu Arg Asn Thr 
        355                 360                 365             


Lys Ser Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp Leu Leu Asn 
    370                 375                 380                 


Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu 
385                 390                 395                 400 


Glu Gly Glu Glu Thr Arg Phe Ser Thr Ser Gly Leu Ser Ile Ser Gly 
                405                 410                 415     


Leu Asn Pro Leu Pro Asn Pro Ser Tyr Leu Leu Pro Pro Arg Ile Leu 
            420                 425                 430         


Ser Ala Thr Thr Ser Lys Val Ser Ser Thr Gly Leu Ser Leu Lys Lys 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Ala Ser Lys Val Ala Ser Lys Lys Thr Ser 
    450                 455                 460                 


Gln Ile Gly Glu Ser Phe Glu Glu Ile Leu Glu Glu Thr Val Ile Ser 
465                 470                 475                 480 


Thr Lys Lys Thr Glu Lys Ser Asn Ile Glu Glu Thr Thr Ile Ser Ser 
                485                 490                 495     


Gln Lys Ile 
            


<210> 6233
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6233
Met Glu Ser Tyr Asp Val Ile Ala Asn Gln Pro Val Val Ile Asp Asn 
1               5                   10                  15      


Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys 
            20                  25                  30          


Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Val Arg Val Met 
        35                  40                  45              


Ala Gly Ala Leu Glu Gly Asp Ile Phe Ile Gly Pro Lys Ala Glu Glu 
    50                  55                  60                  


His Arg Gly Leu Leu Ser Ile Arg Tyr Pro Met Glu His Gly Ile Val 
65                  70                  75                  80  


Lys Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys 
                85                  90                  95      


Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu 
            100                 105                 110         


Ala Pro Leu Asn Pro Arg Lys Asn Arg Glu Arg Ala Ala Glu Val Phe 
        115                 120                 125             


Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val 
    130                 135                 140                 


Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser 
145                 150                 155                 160 


Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met 
                165                 170                 175     


Pro His Ser Ile Met Arg Ile Asp Ile Ala Gly Arg Asp Val Ser Arg 
            180                 185                 190         


Phe Leu Arg Leu Tyr Leu Arg Lys Glu Gly Tyr Asp Phe His Ser Ser 
        195                 200                 205             


Ser Glu Phe Glu Ile Val Lys Ala Ile Lys Glu Arg Ala Cys Tyr Leu 
    210                 215                 220                 


Ser Ile Asn Pro Gln Lys Asp Glu Thr Leu Glu Thr Glu Lys Ala Gln 
225                 230                 235                 240 


Tyr Tyr Leu Pro Asp Gly Ser Thr Ile Glu Ile Gly Pro Ser Arg Phe 
                245                 250                 255     


Arg Ala Pro Glu Leu Leu Phe Arg Pro Asp Leu Ile Gly Glu Glu Ser 
            260                 265                 270         


Glu Gly Ile His Glu Val Leu Val Phe Ala Ile Gln Lys Ser Asp Met 
        275                 280                 285             


Asp Leu Arg Arg Thr Leu Phe Ser Asn Ile Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys 
305                 310                 315                 320 


Leu Ala Pro Lys Asp Val Lys Ile Arg Ile Ser Ala Pro Gln Glu Arg 
                325                 330                 335     


Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr 
            340                 345                 350         


Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ala 
        355                 360                 365             


Arg Ser Ile His Arg Lys Thr Phe 
    370                 375     


<210> 6234
<211> 260
<212> PRT
<213> Homo sapiens

<400> 6234
Met Ser Leu Gln Lys Thr Pro Pro Thr Arg Val Phe Val Glu Leu Val 
1               5                   10                  15      


Pro Trp Ala Asp Arg Ser Arg Glu Asn Asn Leu Ala Ser Gly Arg Glu 
            20                  25                  30          


Thr Leu Pro Gly Leu Arg His Pro Leu Ser Ser Thr Gln Ala Gln Thr 
        35                  40                  45              


Ala Thr Arg Glu Val Gln Val Ser Gly Thr Ser Glu Val Ser Ala Gly 
    50                  55                  60                  


Pro Asp Arg Ala Gln Val Val Val Arg Val Ser Ser Thr Lys Glu Ala 
65                  70                  75                  80  


Ala Ala Glu Ala Lys Lys Ser Val Cys Arg Arg Leu Asp Tyr Ile Thr 
                85                  90                  95      


Gln Ser Leu Gln Gln Gln Gly Val Gln Ala Glu Asn Ile Thr Val Thr 
            100                 105                 110         


Lys Asp Phe Arg Arg Val Glu Asn Ala Tyr His Met Glu Ala Glu Val 
        115                 120                 125             


Cys Ile Thr Phe Thr Glu Phe Gly Lys Met Gln Asn Ile Cys Asn Phe 
    130                 135                 140                 


Leu Val Glu Lys Leu Asp Ser Ser Val Val Ile Ser Pro Pro Gln Phe 
145                 150                 155                 160 


Tyr His Thr Pro Gly Ser Val Glu Asn Leu Arg Arg Gln Ala Cys Leu 
                165                 170                 175     


Val Ala Val Glu Asn Ala Trp Arg Lys Ala Gln Glu Val Cys Asn Leu 
            180                 185                 190         


Val Gly Gln Thr Leu Gly Lys Pro Leu Leu Ile Lys Glu Glu Glu Thr 
        195                 200                 205             


Lys Glu Trp Glu Gly Gln Ile Asp Asp His Gln Ser Ser Arg Leu Ser 
    210                 215                 220                 


Ser Ser Leu Thr Val Gln Gln Lys Ile Lys Ser Ala Thr Ile His Ala 
225                 230                 235                 240 


Ala Ser Lys Val Phe Ile Thr Phe Glu Val Lys Gly Lys Glu Lys Arg 
                245                 250                 255     


Lys Lys His Leu 
            260 


<210> 6235
<211> 296
<212> PRT
<213> Homo sapiens

<400> 6235
Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly Ala Val Arg Phe Leu 
1               5                   10                  15      


Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His Val Leu Asn Arg Val 
            20                  25                  30          


Pro Leu Arg Gln Leu Leu Arg Leu Gln Arg Val Ser Arg Ala Phe Arg 
        35                  40                  45              


Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg Arg Phe Asp Ala Ala 
    50                  55                  60                  


Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala Pro Cys His Glu Trp 
                85                  90                  95      


Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala Arg Asn Pro Gln Leu 
            100                 105                 110         


Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu Ser Arg Arg Ala Leu 
        115                 120                 125             


Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln Arg Leu Ser Leu Ala 
    130                 135                 140                 


His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg Gly Leu Ala Asp Arg 
145                 150                 155                 160 


Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala Cys Arg Gln Leu Lys 
                165                 170                 175     


Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg Arg Gly Ala Gly Leu Arg 
            180                 185                 190         


Ser Leu Ser Leu Ala Val Asn Ala Asn Val Gly Asp Ala Ala Val Gln 
        195                 200                 205             


Glu Leu Ala Arg Asn Cys Pro Glu Leu His His Leu Asp Leu Thr Gly 
    210                 215                 220                 


Cys Leu Arg Val Gly Ser Asp Gly Val Arg Thr Leu Ala Glu Tyr Cys 
225                 230                 235                 240 


Pro Val Leu Arg Ser Leu Arg Val Arg His Cys His His Val Ala Glu 
                245                 250                 255     


Ser Ser Leu Ser Arg Leu Arg Lys Arg Gly Val Asp Ile Asp Val Glu 
            260                 265                 270         


Pro Pro Leu His Gln Ala Leu Val Leu Leu Gln Asp Met Ala Gly Phe 
        275                 280                 285             


Ala Pro Phe Val Asn Leu Gln Val 
    290                 295     


<210> 6236
<211> 699
<212> PRT
<213> Homo sapiens

<400> 6236
Met Ala Asp Ala Gly Ile Arg Arg Val Val Pro Ser Asp Leu Tyr Pro 
1               5                   10                  15      


Leu Val Leu Gly Phe Leu Arg Asp Asn Gln Leu Ser Glu Val Ala Asn 
            20                  25                  30          


Lys Phe Ala Lys Ala Thr Gly Ala Thr Gln Gln Asp Ala Asn Ala Ser 
        35                  40                  45              


Ser Leu Leu Asp Ile Tyr Ser Phe Trp Leu Lys Ser Ala Lys Val Pro 
    50                  55                  60                  


Glu Arg Lys Leu Gln Ala Asn Gly Pro Val Ala Lys Lys Ala Lys Lys 
65                  70                  75                  80  


Lys Ala Ser Ser Ser Asp Ser Glu Asp Ser Ser Glu Glu Glu Glu Glu 
                85                  90                  95      


Val Gln Gly Pro Pro Ala Lys Lys Ala Ala Val Pro Ala Lys Arg Val 
            100                 105                 110         


Gly Leu Pro Pro Gly Lys Ala Ala Ala Lys Ala Ser Glu Ser Ser Ser 
        115                 120                 125             


Ser Glu Glu Ser Ser Asp Asp Asp Asp Glu Glu Asp Gln Lys Lys Gln 
    130                 135                 140                 


Pro Val Gln Lys Gly Val Lys Pro Gln Ala Lys Ala Ala Lys Ala Pro 
145                 150                 155                 160 


Pro Lys Lys Ala Lys Ser Ser Asp Ser Asp Ser Asp Ser Ser Ser Glu 
                165                 170                 175     


Asp Glu Pro Pro Lys Asn Gln Lys Pro Lys Ile Thr Pro Val Thr Val 
            180                 185                 190         


Lys Ala Gln Thr Lys Ala Pro Pro Lys Pro Ala Arg Ala Ala Pro Lys 
        195                 200                 205             


Ile Ala Asn Gly Lys Ala Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    210                 215                 220                 


Ser Ser Ser Asp Asp Ser Glu Glu Glu Lys Ala Ala Ala Thr Pro Lys 
225                 230                 235                 240 


Lys Thr Val Pro Lys Lys Gln Val Val Ala Lys Ala Pro Val Lys Ala 
                245                 250                 255     


Ala Thr Thr Pro Thr Arg Lys Ser Ser Ser Ser Glu Asp Ser Ser Ser 
            260                 265                 270         


Asp Glu Glu Glu Glu Gln Lys Lys Pro Met Lys Asn Lys Pro Gly Pro 
        275                 280                 285             


Tyr Ser Ser Val Pro Pro Pro Ser Ala Pro Pro Pro Lys Lys Ser Leu 
    290                 295                 300                 


Gly Thr Gln Pro Pro Lys Lys Ala Val Glu Lys Gln Gln Pro Val Glu 
305                 310                 315                 320 


Ser Ser Glu Asp Ser Ser Asp Glu Ser Asp Ser Ser Ser Glu Glu Glu 
                325                 330                 335     


Lys Lys Pro Pro Thr Lys Ala Val Val Ser Lys Ala Thr Thr Lys Pro 
            340                 345                 350         


Pro Pro Ala Lys Lys Ala Ala Glu Ser Ser Ser Asp Ser Ser Asp Ser 
        355                 360                 365             


Asp Ser Ser Glu Asp Asp Glu Ala Pro Ser Lys Pro Ala Gly Thr Thr 
    370                 375                 380                 


Lys Asn Ser Ser Asn Lys Pro Ala Val Thr Thr Lys Ser Pro Ala Val 
385                 390                 395                 400 


Lys Pro Ala Ala Ala Pro Lys Gln Pro Val Gly Gly Gly Gln Lys Leu 
                405                 410                 415     


Leu Thr Arg Lys Ala Asp Ser Ser Ser Ser Glu Glu Glu Ser Ser Ser 
            420                 425                 430         


Ser Glu Glu Glu Lys Thr Lys Lys Met Val Ala Thr Thr Lys Pro Lys 
        435                 440                 445             


Ala Thr Ala Lys Ala Ala Leu Ser Leu Pro Ala Lys Gln Ala Pro Gln 
    450                 455                 460                 


Gly Ser Arg Asp Ser Ser Ser Asp Ser Asp Ser Ser Ser Ser Glu Glu 
465                 470                 475                 480 


Glu Glu Glu Lys Thr Ser Lys Ser Ala Val Lys Lys Lys Pro Gln Lys 
                485                 490                 495     


Val Ala Gly Gly Ala Ala Pro Ser Lys Pro Ala Ser Ala Lys Lys Gly 
            500                 505                 510         


Lys Ala Glu Ser Ser Asn Ser Ser Ser Ser Asp Asp Ser Ser Glu Glu 
        515                 520                 525             


Glu Glu Glu Lys Leu Lys Gly Lys Gly Ser Pro Arg Pro Gln Ala Pro 
    530                 535                 540                 


Lys Ala Asn Gly Thr Ser Ala Leu Thr Ala Gln Asn Gly Lys Ala Ala 
545                 550                 555                 560 


Lys Asn Ser Glu Glu Glu Glu Glu Glu Lys Lys Lys Ala Ala Val Val 
                565                 570                 575     


Val Ser Lys Ser Gly Ser Leu Lys Lys Arg Lys Gln Asn Glu Ala Ala 
            580                 585                 590         


Lys Glu Ala Glu Thr Pro Gln Ala Lys Lys Ile Lys Leu Gln Thr Pro 
        595                 600                 605             


Asn Thr Phe Pro Lys Arg Lys Lys Gly Glu Lys Arg Ala Ser Ser Pro 
    610                 615                 620                 


Phe Arg Arg Val Arg Glu Glu Glu Ile Glu Val Asp Ser Arg Val Ala 
625                 630                 635                 640 


Asp Asn Ser Phe Asp Ala Lys Arg Gly Ala Ala Gly Asp Trp Gly Glu 
                645                 650                 655     


Arg Ala Asn Gln Val Leu Lys Phe Thr Lys Gly Lys Ser Phe Arg His 
            660                 665                 670         


Glu Lys Thr Lys Lys Lys Arg Gly Ser Tyr Arg Gly Gly Ser Ile Ser 
        675                 680                 685             


Val Gln Val Asn Ser Ile Lys Phe Asp Ser Glu 
    690                 695                 


<210> 6237
<211> 424
<212> PRT
<213> Homo sapiens

<400> 6237
Met Glu Glu Asn Asn Leu Gln Cys Ser Ser Val Val Asp Gly Asn Phe 
1               5                   10                  15      


Glu Glu Val Pro Arg Glu Thr Ala Ile Gln Phe Lys Pro Pro Leu Tyr 
            20                  25                  30          


Arg Gln Arg Tyr Gln Phe Val Lys Asn Leu Val Asp Gln His Glu Pro 
        35                  40                  45              


Lys Lys Val Ala Asp Leu Gly Cys Gly Asp Thr Ser Leu Leu Arg Leu 
    50                  55                  60                  


Leu Lys Val Asn Pro Cys Ile Glu Leu Leu Val Gly Val Asp Ile Asn 
65                  70                  75                  80  


Glu Asp Lys Leu Arg Trp Arg Gly Asp Ser Leu Ala Pro Phe Leu Gly 
                85                  90                  95      


Asp Phe Leu Lys Pro Arg Asp Leu Asn Leu Thr Ile Thr Leu Tyr His 
            100                 105                 110         


Gly Ser Val Val Glu Arg Asp Ser Arg Leu Leu Gly Phe Asp Leu Ile 
        115                 120                 125             


Thr Cys Ile Glu Leu Ile Glu His Leu Asp Ser Gly Asp Leu Ala Arg 
    130                 135                 140                 


Phe Pro Glu Val Val Phe Gly Tyr Leu Ser Pro Ser Met Ile Val Ile 
145                 150                 155                 160 


Ser Thr Pro Asn Ser Glu Phe Asn Pro Leu Phe Pro Ser Val Thr Leu 
                165                 170                 175     


Arg Asp Ser Asp His Lys Phe Glu Trp Thr Arg Met Glu Phe Gln Thr 
            180                 185                 190         


Trp Ala Leu Tyr Val Ala Asn Arg Tyr Asp Tyr Ser Val Glu Phe Thr 
        195                 200                 205             


Gly Val Gly Glu Pro Pro Ala Gly Ala Glu Asn Val Gly Tyr Cys Thr 
    210                 215                 220                 


Gln Ile Gly Ile Phe Arg Lys Asn Gly Gly Lys Ala Thr Glu Ser Cys 
225                 230                 235                 240 


Leu Ser Glu Gln His Asp Gln His Val Tyr Lys Ala Arg Gln Gly Leu 
                245                 250                 255     


Thr Met Leu Pro Arg Leu Val Leu Asn Phe His Pro Gln Ala Ile Leu 
            260                 265                 270         


Leu Pro His Leu Pro Lys Met Leu Arg Leu Gln Val Phe Thr Thr Ser 
        275                 280                 285             


Tyr Pro Ser Leu Gln Gln Glu Arg Phe Phe Lys Leu Val Leu Val Asn 
    290                 295                 300                 


Glu Val Ser Gln Gln Val Glu Ser Leu Arg Val Ser His Leu Pro Arg 
305                 310                 315                 320 


Arg Lys Glu Gln Ala Gly Glu Arg Gly Asp Lys Pro Lys Asp Ile Gly 
                325                 330                 335     


Gly Ser Lys Ala Pro Val Pro Cys Phe Gly Pro Val Phe Thr Glu Val 
            340                 345                 350         


Glu Lys Ala Lys Ile Glu Asn Ser Pro Thr Pro Phe Cys Val Gly Asp 
        355                 360                 365             


Lys Phe Phe Val Pro Leu Gln Arg Leu Leu Ala Tyr Pro Lys Leu Asn 
    370                 375                 380                 


Arg Leu Cys Ala Asn Glu Glu Met Met Arg Ser Val Ile Ala Asp Ser 
385                 390                 395                 400 


Ile Pro Leu Ser Ser Asp Gly Ser Ala Val Val Ala Asp Leu Arg Asn 
                405                 410                 415     


Tyr Phe Asp Glu Gln Phe Glu Phe 
            420                 


<210> 6238
<211> 393
<212> PRT
<213> Homo sapiens

<400> 6238
Met Glu Glu Asn Asn Leu Gln Cys Ser Ser Val Val Asp Gly Asn Phe 
1               5                   10                  15      


Glu Glu Val Pro Arg Glu Thr Ala Ile Gln Phe Lys Pro Pro Leu Tyr 
            20                  25                  30          


Arg Gln Arg Tyr Gln Phe Val Lys Asn Leu Val Asp Gln His Glu Pro 
        35                  40                  45              


Lys Lys Val Ala Asp Leu Gly Cys Gly Asp Thr Ser Leu Leu Arg Leu 
    50                  55                  60                  


Leu Lys Val Asn Pro Cys Ile Glu Leu Leu Val Gly Val Asp Ile Asn 
65                  70                  75                  80  


Glu Asp Lys Leu Arg Trp Arg Gly Asp Ser Leu Ala Pro Phe Leu Gly 
                85                  90                  95      


Asp Phe Leu Lys Pro Arg Asp Leu Asn Leu Thr Ile Thr Leu Tyr His 
            100                 105                 110         


Gly Ser Val Val Glu Arg Asp Ser Arg Leu Leu Gly Phe Asp Leu Ile 
        115                 120                 125             


Thr Cys Ile Glu Leu Ile Glu His Leu Asp Ser Gly Asp Leu Ala Arg 
    130                 135                 140                 


Phe Pro Glu Val Val Phe Gly Tyr Leu Ser Pro Ser Met Ile Val Ile 
145                 150                 155                 160 


Ser Thr Pro Asn Ser Glu Phe Asn Pro Leu Phe Pro Ser Val Thr Leu 
                165                 170                 175     


Arg Asp Ser Asp His Lys Phe Glu Trp Thr Arg Met Glu Phe Gln Thr 
            180                 185                 190         


Trp Ala Leu Tyr Val Ala Asn Arg Tyr Asp Tyr Ser Val Glu Phe Thr 
        195                 200                 205             


Gly Val Gly Glu Pro Pro Ala Gly Ala Glu Asn Val Gly Tyr Cys Thr 
    210                 215                 220                 


Gln Ile Gly Ile Phe Arg Lys Asn Gly Gly Lys Ala Thr Glu Ser Cys 
225                 230                 235                 240 


Leu Ser Glu Gln His Asp Gln His Val Tyr Lys Ala Val Phe Thr Thr 
                245                 250                 255     


Ser Tyr Pro Ser Leu Gln Gln Glu Arg Phe Phe Lys Leu Val Leu Val 
            260                 265                 270         


Asn Glu Val Ser Gln Gln Val Glu Ser Leu Arg Val Ser His Leu Pro 
        275                 280                 285             


Arg Arg Lys Glu Gln Ala Gly Glu Arg Gly Asp Lys Pro Lys Asp Ile 
    290                 295                 300                 


Gly Gly Ser Lys Ala Pro Val Pro Cys Phe Gly Pro Val Phe Thr Glu 
305                 310                 315                 320 


Val Glu Lys Ala Lys Ile Glu Asn Ser Pro Thr Pro Phe Cys Val Gly 
                325                 330                 335     


Asp Lys Phe Phe Val Pro Leu Gln Arg Leu Leu Ala Tyr Pro Lys Leu 
            340                 345                 350         


Asn Arg Leu Cys Ala Asn Glu Glu Met Met Arg Ser Val Ile Ala Asp 
        355                 360                 365             


Ser Ile Pro Leu Ser Ser Asp Gly Ser Ala Val Val Ala Asp Leu Arg 
    370                 375                 380                 


Asn Tyr Phe Asp Glu Gln Phe Glu Phe 
385                 390             


<210> 6239
<211> 566
<212> PRT
<213> Homo sapiens

<400> 6239
Met Ser Ala Ser Thr Gly Gly Gly Gly Asp Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Ser Ser Ser Ser Ser Gln Ala Ser Cys Gly Pro Glu Ser Ser Gly Ser 
            20                  25                  30          


Glu Leu Ala Leu Ala Thr Pro Val Pro Gln Met Leu Gln Gly Leu Leu 
        35                  40                  45              


Gly Ser Asp Asp Glu Glu Gln Glu Asp Pro Lys Asp Tyr Cys Lys Gly 
    50                  55                  60                  


Gly Tyr His Pro Val Lys Ile Gly Asp Val Phe Asn Gly Arg Tyr His 
65                  70                  75                  80  


Val Val Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu Cys 
                85                  90                  95      


Trp Asp Ile Gln Arg Lys Arg Phe Val Ala Leu Lys Val Val Lys Ser 
            100                 105                 110         


Ala Gly His Tyr Thr Glu Thr Ala Val Asp Glu Ile Lys Leu Leu Lys 
        115                 120                 125             


Cys Val Arg Asp Ser Asp Pro Ser Asp Pro Lys Arg Glu Thr Ile Val 
    130                 135                 140                 


Gln Leu Ile Asp Asp Phe Arg Ile Ser Gly Val Asn Gly Val His Val 
145                 150                 155                 160 


Cys Met Val Leu Glu Val Leu Gly His Gln Leu Leu Lys Trp Ile Ile 
                165                 170                 175     


Lys Ser Asn Tyr Gln Gly Leu Pro Val Pro Cys Val Lys Ser Ile Val 
            180                 185                 190         


Arg Gln Val Leu His Gly Leu Asp Tyr Leu His Thr Lys Cys Lys Ile 
        195                 200                 205             


Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Leu Cys Val Gly Asp 
    210                 215                 220                 


Ala Tyr Ile Arg Arg Leu Ala Ala Glu Ala Thr Glu Trp Gln Gln Ala 
225                 230                 235                 240 


Gly Ala Pro Pro Pro Ser Arg Ser Ile Val Ser Thr Ala Pro Gln Glu 
                245                 250                 255     


Val Leu Thr Gly Lys Leu Ser Lys Asn Lys Arg Lys Lys Met Arg Arg 
            260                 265                 270         


Lys Arg Lys Gln Gln Lys Arg Leu Leu Glu Glu Arg Leu Arg Asp Leu 
        275                 280                 285             


Gln Arg Leu Glu Ala Met Glu Ala Ala Thr Gln Ala Glu Asp Ser Gly 
    290                 295                 300                 


Leu Arg Leu Asp Gly Gly Ser Gly Ser Thr Ser Ser Ser Gly Cys His 
305                 310                 315                 320 


Pro Gly Gly Ala Arg Ala Gly Pro Ser Pro Ala Ser Ser Ser Pro Ala 
                325                 330                 335     


Pro Gly Gly Gly Arg Ser Leu Ser Ala Gly Ser Gln Thr Ser Gly Phe 
            340                 345                 350         


Ser Gly Ser Leu Phe Ser Pro Ala Ser Cys Ser Ile Leu Ser Gly Ser 
        355                 360                 365             


Ser Asn Gln Arg Glu Thr Gly Gly Leu Leu Ser Pro Ser Thr Pro Phe 
    370                 375                 380                 


Gly Ala Ser Asn Leu Leu Val Asn Pro Leu Glu Pro Gln Asn Ala Asp 
385                 390                 395                 400 


Lys Ile Lys Ile Lys Ile Ala Asp Leu Gly Asn Ala Cys Trp Val His 
                405                 410                 415     


Lys His Phe Thr Glu Asp Ile Gln Thr Arg Gln Tyr Arg Ala Val Glu 
            420                 425                 430         


Val Leu Ile Gly Ala Glu Tyr Gly Pro Pro Ala Asp Ile Trp Ser Thr 
        435                 440                 445             


Ala Cys Met Ala Phe Glu Leu Ala Thr Gly Asp Tyr Leu Phe Glu Pro 
    450                 455                 460                 


His Ser Gly Glu Asp Tyr Ser Arg Asp Glu Asp His Ile Ala His Ile 
465                 470                 475                 480 


Val Glu Leu Leu Gly Asp Ile Pro Pro Ala Phe Ala Leu Ser Gly Arg 
                485                 490                 495     


Tyr Ser Arg Glu Phe Phe Asn Arg Arg Gly Glu Leu Arg His Ile His 
            500                 505                 510         


Asn Leu Lys His Trp Gly Leu Tyr Glu Val Leu Met Glu Lys Tyr Glu 
        515                 520                 525             


Trp Pro Leu Glu Gln Ala Thr Gln Phe Ser Ala Phe Leu Leu Pro Met 
    530                 535                 540                 


Met Glu Tyr Ile Pro Glu Lys Arg Ala Ser Ala Ala Asp Cys Leu Gln 
545                 550                 555                 560 


His Pro Trp Leu Asn Pro 
                565     


<210> 6240
<211> 49
<212> PRT
<213> Homo sapiens

<400> 6240
Met Ala Gly Pro Arg Val Glu Val Asp Gly Ser Ile Met Glu Gly Gly 
1               5                   10                  15      


Gly Gln Ile Leu Arg Val Ser Thr Ala Leu Ser Cys Leu Leu Gly Leu 
            20                  25                  30          


Pro Leu Arg Val Gln Lys Ile Arg Ala Gly Arg Ser Thr Pro Gly Leu 
        35                  40                  45              


Arg 
    


<210> 6241
<211> 366
<212> PRT
<213> Homo sapiens

<400> 6241
Met Ala Gly Pro Arg Val Glu Val Asp Gly Ser Ile Met Glu Gly Gly 
1               5                   10                  15      


Gly Gln Ile Leu Arg Val Ser Thr Ala Leu Ser Cys Leu Leu Gly Leu 
            20                  25                  30          


Pro Leu Arg Val Gln Lys Ile Arg Ala Gly Arg Ser Thr Pro Gly Leu 
        35                  40                  45              


Arg Pro Gln His Leu Ser Gly Leu Glu Met Ile Arg Asp Leu Cys Asp 
    50                  55                  60                  


Gly Gln Leu Glu Gly Ala Glu Ile Gly Ser Thr Glu Ile Thr Phe Thr 
65                  70                  75                  80  


Pro Glu Lys Ile Lys Gly Gly Ile His Thr Ala Asp Thr Lys Thr Ala 
                85                  90                  95      


Gly Ser Val Cys Leu Leu Met Gln Val Ser Met Pro Cys Val Leu Phe 
            100                 105                 110         


Ala Ala Ser Pro Ser Glu Leu His Leu Lys Gly Gly Thr Asn Ala Glu 
        115                 120                 125             


Met Ala Pro Gln Ile Asp Tyr Thr Val Met Val Phe Lys Pro Ile Val 
    130                 135                 140                 


Glu Lys Phe Gly Phe Ile Phe Asn Cys Asp Ile Lys Thr Arg Gly Tyr 
145                 150                 155                 160 


Tyr Pro Lys Gly Gly Gly Glu Val Ile Val Arg Met Ser Pro Val Lys 
                165                 170                 175     


Gln Leu Asn Pro Ile Asn Leu Thr Glu Arg Gly Cys Val Thr Lys Ile 
            180                 185                 190         


Tyr Gly Arg Ala Phe Val Ala Gly Val Leu Pro Phe Lys Val Ala Lys 
        195                 200                 205             


Asp Met Ala Ala Ala Ala Val Arg Cys Ile Arg Lys Glu Ile Arg Asp 
    210                 215                 220                 


Leu Tyr Val Asn Ile Gln Pro Val Gln Glu Pro Lys Asp Gln Ala Phe 
225                 230                 235                 240 


Gly Asn Gly Asn Gly Ile Ile Ile Ile Ala Glu Thr Ser Thr Gly Cys 
                245                 250                 255     


Leu Phe Ala Gly Ser Ser Leu Gly Lys Arg Gly Val Asn Ala Asp Lys 
            260                 265                 270         


Val Gly Ile Glu Ala Ala Glu Met Leu Leu Ala Asn Leu Arg His Gly 
        275                 280                 285             


Gly Thr Val Asp Glu Tyr Leu Gln Asp Gln Leu Ile Val Phe Met Ala 
    290                 295                 300                 


Leu Ala Asn Gly Val Ser Arg Ile Lys Thr Gly Pro Val Thr Leu His 
305                 310                 315                 320 


Thr Gln Thr Ala Ile His Phe Ala Glu Gln Ile Ala Lys Ala Lys Phe 
                325                 330                 335     


Ile Val Lys Lys Ser Glu Asp Glu Glu Asp Ala Ala Lys Asp Thr Tyr 
            340                 345                 350         


Ile Ile Glu Cys Gln Gly Ile Gly Met Thr Asn Pro Asn Leu 
        355                 360                 365     


<210> 6242
<211> 384
<212> PRT
<213> Homo sapiens

<400> 6242
Met Glu Gly Leu Gly Arg Ser Cys Leu Trp Leu Arg Arg Glu Leu Ser 
1               5                   10                  15      


Pro Pro Arg Pro Arg Leu Leu Leu Leu Asp Cys Arg Ser Arg Glu Leu 
            20                  25                  30          


Tyr Glu Ser Ala Arg Ile Gly Gly Ala Leu Ser Val Ala Leu Pro Ala 
        35                  40                  45              


Leu Leu Leu Arg Arg Leu Arg Arg Gly Ser Leu Ser Val Arg Ala Leu 
    50                  55                  60                  


Leu Pro Gly Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro Val Leu Leu 
65                  70                  75                  80  


Tyr Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala Glu Ala Glu 
                85                  90                  95      


Ala Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu Leu Gln Lys 
            100                 105                 110         


Leu Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly Gly Phe Ser 
        115                 120                 125             


Arg Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser Leu Ala Gly 
    130                 135                 140                 


Arg Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val Pro Val Val 
145                 150                 155                 160 


Gly Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp Ala Glu Ser 
                165                 170                 175     


Glu Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser Glu Gly Ala 
            180                 185                 190         


Thr Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val Gln Ile Leu 
        195                 200                 205             


Pro Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn Leu Glu Ser 
    210                 215                 220                 


Leu Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr Pro Asn Leu 
225                 230                 235                 240 


Pro Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys Gln Ile Pro 
                245                 250                 255     


Ile Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe Pro Glu Ala 
            260                 265                 270         


Ile Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly Val Leu Val 
        275                 280                 285             


His Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr Val Ala Tyr 
    290                 295                 300                 


Leu Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr Asp Leu Val 
305                 310                 315                 320 


Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln 
                325                 330                 335     


Leu Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg His Ser Gln 
            340                 345                 350         


Glu Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn Pro Pro Ser 
        355                 360                 365             


Phe Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu Ala Pro Thr 
    370                 375                 380                 


<210> 6243
<211> 267
<212> PRT
<213> Homo sapiens

<400> 6243
Met Ala Glu Pro Val Gln Glu Glu Leu Ser Val Leu Ala Ala Ile Phe 
1               5                   10                  15      


Cys Arg Pro His Glu Trp Glu Val Leu Ser Arg Ser Glu Thr Asp Gly 
            20                  25                  30          


Thr Val Phe Arg Ile His Thr Lys Ala Glu Gly Phe Met Asp Val Asp 
        35                  40                  45              


Ile Pro Leu Glu Leu Val Phe His Leu Pro Val Asn Tyr Pro Ser Cys 
    50                  55                  60                  


Leu Pro Gly Ile Ser Ile Asn Ser Glu Gln Leu Thr Arg Ala Gln Cys 
65                  70                  75                  80  


Val Thr Val Lys Glu Asn Leu Leu Glu Gln Ala Glu Ser Leu Leu Ser 
                85                  90                  95      


Glu Pro Met Val His Glu Leu Val Leu Trp Ile Gln Gln Asn Leu Arg 
            100                 105                 110         


His Ile Leu Ser Gln Pro Glu Thr Gly Ser Gly Ser Glu Lys Cys Thr 
        115                 120                 125             


Phe Ser Thr Ser Thr Thr Met Asp Asp Gly Leu Trp Ile Thr Leu Leu 
    130                 135                 140                 


His Leu Asp His Met Arg Ala Lys Thr Lys Tyr Val Lys Ile Val Glu 
145                 150                 155                 160 


Lys Trp Ala Ser Asp Leu Arg Leu Thr Gly Arg Leu Met Phe Met Gly 
                165                 170                 175     


Lys Ile Ile Leu Ile Leu Leu Gln Gly Asp Arg Asn Asn Leu Lys Glu 
            180                 185                 190         


Tyr Leu Ile Leu Gln Lys Thr Ser Lys Val Asp Val Asp Ser Ser Gly 
        195                 200                 205             


Lys Lys Cys Lys Glu Lys Met Ile Ser Val Leu Phe Glu Thr Lys Val 
    210                 215                 220                 


Gln Thr Glu His Lys Arg Phe Leu Ala Phe Glu Val Lys Glu Tyr Ser 
225                 230                 235                 240 


Ala Leu Asp Glu Leu Gln Lys Glu Phe Glu Thr Ala Gly Leu Lys Lys 
                245                 250                 255     


Leu Phe Ser Glu Phe Val Leu Ala Leu Val Lys 
            260                 265         


<210> 6244
<211> 669
<212> PRT
<213> Homo sapiens

<400> 6244
Met Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser Val Ser Ser Leu 
            20                  25                  30          


Ile Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His 
        35                  40                  45              


Gly Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp Gly Leu Leu Arg 
    50                  55                  60                  


Gly Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala Val Pro Pro Arg 
65                  70                  75                  80  


Lys Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn Glu Asp Phe Arg 
                85                  90                  95      


Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu 
            100                 105                 110         


Gln Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu Ile 
        115                 120                 125             


Pro Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys Ile Leu Ile Arg 
    130                 135                 140                 


Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser 
145                 150                 155                 160 


Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gln 
                165                 170                 175     


Gly Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser Ser Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ala Ala Asp Lys Pro Leu Ala Phe Ser Gly Trp 
        195                 200                 205             


Ala Ser Gly Cys Pro Ser Gly Thr Leu Ser Asp Ser Gly Arg Asn Ser 
    210                 215                 220                 


Leu Ser Ser Leu Pro Thr Tyr Ser Thr Gly Gly Ala Glu Pro Thr Thr 
225                 230                 235                 240 


Ser Ser Pro Gly Gly His Leu Pro Ser His Gly Ser Gly Arg Gly Ala 
                245                 250                 255     


Leu Pro Gly Pro Ala Arg Gly Val Pro Thr Gly Pro Ser His Ser Asp 
            260                 265                 270         


Ser Gly Arg Ser Ser Ser Ser Lys Ser Thr Gly Ser Leu Gly Gly Arg 
        275                 280                 285             


Val Ala Gly Gly Leu Leu Gly Ser Gly Thr Arg Ala Ser Pro Asp Ser 
    290                 295                 300                 


Ser Ser Cys Gly Glu Arg Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
305                 310                 315                 320 


Asp Glu Ala Leu Leu His Cys Val Leu Glu Gly Lys Leu Arg Asp Arg 
                325                 330                 335     


Glu Ala Glu Leu Gln Gln Leu Arg Asp Ser Leu Asp Glu Asn Glu Ala 
            340                 345                 350         


Thr Met Cys Gln Ala Tyr Glu Glu Arg Gln Arg His Trp Gln Arg Glu 
        355                 360                 365             


Arg Glu Ala Leu Arg Glu Asp Cys Ala Ala Gln Ala Gln Arg Ala Gln 
    370                 375                 380                 


Arg Ala Gln Gln Leu Leu Gln Leu Gln Val Phe Gln Leu Gln Gln Glu 
385                 390                 395                 400 


Lys Arg Gln Leu Gln Asp Asp Phe Ala Gln Leu Leu Gln Glu Arg Glu 
                405                 410                 415     


Gln Leu Glu Arg Arg Cys Ala Thr Leu Glu Arg Glu Gln Arg Glu Leu 
            420                 425                 430         


Gly Pro Arg Leu Glu Glu Thr Lys Trp Glu Val Cys Gln Lys Ser Gly 
        435                 440                 445             


Glu Ile Ser Leu Leu Lys Gln Gln Leu Lys Glu Ser Gln Ala Glu Leu 
    450                 455                 460                 


Val Gln Lys Gly Ser Glu Leu Val Ala Leu Arg Val Ala Leu Arg Glu 
465                 470                 475                 480 


Ala Arg Ala Thr Leu Arg Val Ser Glu Gly Arg Ala Arg Gly Leu Gln 
                485                 490                 495     


Glu Ala Ala Arg Ala Arg Glu Leu Glu Leu Glu Ala Cys Ser Gln Glu 
            500                 505                 510         


Leu Gln Arg His Arg Gln Glu Ala Glu Gln Leu Arg Glu Lys Ala Gly 
        515                 520                 525             


Gln Leu Asp Ala Glu Ala Ala Gly Leu Arg Glu Pro Pro Val Pro Pro 
    530                 535                 540                 


Ala Thr Ala Asp Pro Phe Leu Leu Ala Glu Ser Asp Glu Ala Lys Val 
545                 550                 555                 560 


Gln Arg Ala Ala Ala Gly Val Gly Gly Ser Leu Arg Ala Gln Val Glu 
                565                 570                 575     


Arg Leu Arg Val Glu Leu Gln Arg Glu Arg Arg Arg Gly Glu Glu Gln 
            580                 585                 590         


Arg Asp Ser Phe Glu Gly Glu Arg Leu Ala Trp Gln Ala Glu Lys Glu 
        595                 600                 605             


Gln Val Ile Arg Tyr Gln Lys Gln Leu Gln His Asn Tyr Ile Gln Met 
    610                 615                 620                 


Tyr Arg Arg Asn Arg Gln Leu Glu Gln Glu Leu Gln Gln Leu Ser Leu 
625                 630                 635                 640 


Glu Leu Glu Ala Arg Glu Leu Ala Asp Leu Gly Leu Ala Glu Gln Ala 
                645                 650                 655     


Pro Cys Ile Cys Leu Glu Glu Ile Thr Ala Thr Glu Ile 
            660                 665                 


<210> 6245
<211> 669
<212> PRT
<213> Homo sapiens

<400> 6245
Met Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser Val Ser Ser Leu 
            20                  25                  30          


Ile Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His 
        35                  40                  45              


Gly Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp Gly Leu Leu Arg 
    50                  55                  60                  


Gly Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala Val Pro Pro Arg 
65                  70                  75                  80  


Lys Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn Glu Asp Phe Arg 
                85                  90                  95      


Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu 
            100                 105                 110         


Gln Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu Ile 
        115                 120                 125             


Pro Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys Ile Leu Ile Arg 
    130                 135                 140                 


Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser 
145                 150                 155                 160 


Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gln 
                165                 170                 175     


Gly Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser Ser Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ala Ala Asp Lys Pro Leu Ala Phe Ser Gly Trp 
        195                 200                 205             


Ala Ser Gly Cys Pro Ser Gly Thr Leu Ser Asp Ser Gly Arg Asn Ser 
    210                 215                 220                 


Leu Ser Ser Leu Pro Thr Tyr Ser Thr Gly Gly Ala Glu Pro Thr Thr 
225                 230                 235                 240 


Ser Ser Pro Gly Gly His Leu Pro Ser His Gly Ser Gly Arg Gly Ala 
                245                 250                 255     


Leu Pro Gly Pro Ala Arg Gly Val Pro Thr Gly Pro Ser His Ser Asp 
            260                 265                 270         


Ser Gly Arg Ser Ser Ser Ser Lys Ser Thr Gly Ser Leu Gly Gly Arg 
        275                 280                 285             


Val Ala Gly Gly Leu Leu Gly Ser Gly Thr Arg Ala Ser Pro Asp Ser 
    290                 295                 300                 


Ser Ser Cys Gly Glu Arg Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
305                 310                 315                 320 


Asp Glu Ala Leu Leu His Cys Val Leu Glu Gly Lys Leu Arg Asp Arg 
                325                 330                 335     


Glu Ala Glu Leu Gln Gln Leu Arg Asp Ser Leu Asp Glu Asn Glu Ala 
            340                 345                 350         


Thr Met Cys Gln Ala Tyr Glu Glu Arg Gln Arg His Trp Gln Arg Glu 
        355                 360                 365             


Arg Glu Ala Leu Arg Glu Asp Cys Ala Ala Gln Ala Gln Arg Ala Gln 
    370                 375                 380                 


Arg Ala Gln Gln Leu Leu Gln Leu Gln Val Phe Gln Leu Gln Gln Glu 
385                 390                 395                 400 


Lys Arg Gln Leu Gln Asp Asp Phe Ala Gln Leu Leu Gln Glu Arg Glu 
                405                 410                 415     


Gln Leu Glu Arg Arg Cys Ala Thr Leu Glu Arg Glu Gln Arg Glu Leu 
            420                 425                 430         


Gly Pro Arg Leu Glu Glu Thr Lys Trp Glu Val Cys Gln Lys Ser Gly 
        435                 440                 445             


Glu Ile Ser Leu Leu Lys Gln Gln Leu Lys Glu Ser Gln Ala Glu Leu 
    450                 455                 460                 


Val Gln Lys Gly Ser Glu Leu Val Ala Leu Arg Val Ala Leu Arg Glu 
465                 470                 475                 480 


Ala Arg Ala Thr Leu Arg Val Ser Glu Gly Arg Ala Arg Gly Leu Gln 
                485                 490                 495     


Glu Ala Ala Arg Ala Arg Glu Leu Glu Leu Glu Ala Cys Ser Gln Glu 
            500                 505                 510         


Leu Gln Arg His Arg Gln Glu Ala Glu Gln Leu Arg Glu Lys Ala Gly 
        515                 520                 525             


Gln Leu Asp Ala Glu Ala Ala Gly Leu Arg Glu Pro Pro Val Pro Pro 
    530                 535                 540                 


Ala Thr Ala Asp Pro Phe Leu Leu Ala Glu Ser Asp Glu Ala Lys Val 
545                 550                 555                 560 


Gln Arg Ala Ala Ala Gly Val Gly Gly Ser Leu Arg Ala Gln Val Glu 
                565                 570                 575     


Arg Leu Arg Val Glu Leu Gln Arg Glu Arg Arg Arg Gly Glu Glu Gln 
            580                 585                 590         


Arg Asp Ser Phe Glu Gly Glu Arg Leu Ala Trp Gln Ala Glu Lys Glu 
        595                 600                 605             


Gln Val Ile Arg Tyr Gln Lys Gln Leu Gln His Asn Tyr Ile Gln Met 
    610                 615                 620                 


Tyr Arg Arg Asn Arg Gln Leu Glu Gln Glu Leu Gln Gln Leu Ser Leu 
625                 630                 635                 640 


Glu Leu Glu Ala Arg Glu Leu Ala Asp Leu Gly Leu Ala Glu Gln Ala 
                645                 650                 655     


Pro Cys Ile Cys Leu Glu Glu Ile Thr Ala Thr Glu Ile 
            660                 665                 


<210> 6246
<211> 352
<212> PRT
<213> Homo sapiens

<400> 6246
Met Lys Leu Lys Glu Leu Glu Arg Pro Ala Val Gln Ala Trp Ser Pro 
1               5                   10                  15      


Ala Ser Gln Tyr Pro Leu Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
            20                  25                  30          


Leu Asp Ser Ser Phe Ser Thr Asn Gly Thr Leu Glu Ile Phe Glu Val 
        35                  40                  45              


Asp Phe Arg Asp Pro Ser Leu Asp Leu Lys His Arg Gly Val Leu Ser 
    50                  55                  60                  


Ala Leu Ser Arg Phe His Lys Leu Val Trp Gly Ser Phe Gly Ser Gly 
65                  70                  75                  80  


Leu Leu Glu Ser Ser Gly Val Ile Val Gly Gly Gly Asp Asn Gly Met 
                85                  90                  95      


Leu Ile Leu Tyr Asn Val Thr His Ile Leu Ser Ser Gly Lys Glu Pro 
            100                 105                 110         


Val Ile Ala Gln Lys Gln Lys His Thr Gly Ala Val Arg Ala Leu Asp 
        115                 120                 125             


Leu Asn Pro Phe Gln Gly Asn Leu Leu Ala Ser Gly Ala Ser Asp Ser 
    130                 135                 140                 


Glu Ile Phe Ile Trp Asp Leu Asn Asn Leu Asn Val Pro Met Thr Leu 
145                 150                 155                 160 


Gly Ser Lys Ser Gln Tyr His Glu Gln Pro Pro Glu Asp Ile Lys Ala 
                165                 170                 175     


Leu Ser Trp Asn Arg Gln Ala Gln His Ile Leu Ser Ser Ala His Pro 
            180                 185                 190         


Ser Gly Lys Ala Val Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile 
        195                 200                 205             


Lys Val Ser Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp 
    210                 215                 220                 


His Pro Asp Ile Ala Thr Gln Leu Val Leu Cys Ser Glu Asp Asp Arg 
225                 230                 235                 240 


Leu Pro Val Ile Gln Leu Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu 
                245                 250                 255     


Lys Val Leu Glu Ser His Ser Arg Gly Ile Leu Ser Val Ser Trp Ser 
            260                 265                 270         


Gln Ala Asp Ala Glu Leu Leu Leu Thr Ser Ala Lys Asp Ser Gln Ile 
        275                 280                 285             


Leu Cys Arg Asn Leu Gly Ser Ser Glu Val Val Tyr Lys Leu Pro Thr 
    290                 295                 300                 


Gln Ser Ser Trp Cys Phe Asp Val Gln Trp Cys Pro Arg Asp Pro Ser 
305                 310                 315                 320 


Val Phe Ser Ala Ala Ser Phe Asn Gly Trp Ile Ser Leu Tyr Ser Val 
                325                 330                 335     


Met Gly Arg Ser Trp Glu Val Gln His Met Arg Gln Ala Asp Lys Val 
            340                 345                 350         


<210> 6247
<211> 1179
<212> PRT
<213> Homo sapiens

<400> 6247
Met Lys Leu Lys Glu Leu Glu Arg Pro Ala Val Gln Ala Trp Ser Pro 
1               5                   10                  15      


Ala Ser Gln Tyr Pro Leu Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
            20                  25                  30          


Leu Asp Ser Ser Phe Ser Thr Asn Gly Thr Leu Glu Ile Phe Glu Val 
        35                  40                  45              


Asp Phe Arg Asp Pro Ser Leu Asp Leu Lys His Arg Gly Val Leu Ser 
    50                  55                  60                  


Ala Leu Ser Arg Phe His Lys Leu Val Trp Gly Ser Phe Gly Ser Gly 
65                  70                  75                  80  


Leu Leu Glu Ser Ser Gly Val Ile Val Gly Gly Gly Asp Asn Gly Met 
                85                  90                  95      


Leu Ile Leu Tyr Asn Val Thr His Ile Leu Ser Ser Gly Lys Glu Pro 
            100                 105                 110         


Val Ile Ala Gln Lys Gln Lys His Thr Gly Ala Val Arg Ala Leu Asp 
        115                 120                 125             


Leu Asn Pro Phe Gln Gly Asn Leu Leu Ala Ser Gly Ala Ser Asp Ser 
    130                 135                 140                 


Glu Ile Phe Ile Trp Asp Leu Asn Asn Leu Asn Val Pro Met Thr Leu 
145                 150                 155                 160 


Gly Ser Lys Ser Gln Gln Pro Pro Glu Asp Ile Lys Ala Leu Ser Trp 
                165                 170                 175     


Asn Arg Gln Ala Gln His Ile Leu Ser Ser Ala His Pro Ser Gly Lys 
            180                 185                 190         


Ala Val Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile Lys Val Ser 
        195                 200                 205             


Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp His Pro Asp 
    210                 215                 220                 


Ile Ala Thr Gln Leu Val Leu Cys Ser Glu Asp Asp Arg Leu Pro Val 
225                 230                 235                 240 


Ile Gln Leu Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Lys Val Leu 
                245                 250                 255     


Glu Ser His Ser Arg Gly Ile Leu Ser Val Ser Trp Ser Gln Ala Asp 
            260                 265                 270         


Ala Glu Leu Leu Leu Thr Ser Ala Lys Asp Ser Gln Ile Leu Cys Arg 
        275                 280                 285             


Asn Leu Gly Ser Ser Glu Val Val Tyr Lys Leu Pro Thr Gln Ser Ser 
    290                 295                 300                 


Trp Cys Phe Asp Val Gln Trp Cys Pro Arg Asp Pro Ser Val Phe Ser 
305                 310                 315                 320 


Ala Ala Ser Phe Asn Gly Trp Ile Ser Leu Tyr Ser Val Met Gly Arg 
                325                 330                 335     


Ser Trp Glu Val Gln His Met Arg Gln Ala Asp Lys Ile Ser Ser Ser 
            340                 345                 350         


Phe Ser Lys Gly Gln Pro Leu Pro Pro Leu Gln Val Pro Glu Gln Val 
        355                 360                 365             


Ala Gln Ala Pro Leu Ile Pro Pro Leu Lys Lys Pro Pro Lys Trp Ile 
    370                 375                 380                 


Arg Arg Pro Thr Gly Val Ser Phe Ala Phe Gly Gly Lys Leu Val Thr 
385                 390                 395                 400 


Phe Gly Leu Pro Ser Thr Pro Ala His Leu Val Pro Gln Pro Cys Pro 
                405                 410                 415     


Arg Leu Val Phe Ile Ser Gln Val Thr Thr Glu Ser Glu Phe Leu Met 
            420                 425                 430         


Arg Ser Ala Glu Leu Gln Glu Ala Leu Gly Ser Gly Asn Leu Leu Asn 
        435                 440                 445             


Tyr Cys Gln Asn Lys Ser Gln Gln Ala Leu Leu Gln Ser Glu Lys Met 
    450                 455                 460                 


Leu Trp Gln Phe Leu Lys Val Thr Leu Glu Gln Asp Ser Arg Met Lys 
465                 470                 475                 480 


Phe Leu Lys Leu Leu Gly Tyr Ser Lys Asp Glu Leu Gln Lys Lys Val 
                485                 490                 495     


Ala Thr Trp Leu Lys Ser Asp Val Gly Leu Gly Glu Ser Pro Gln Pro 
            500                 505                 510         


Lys Gly Asn Asp Leu Asn Ser Asp Arg Gln Gln Ala Phe Cys Ser Gln 
        515                 520                 525             


Ala Ser Lys His Thr Thr Lys Glu Ala Ser Ala Ser Ser Ala Phe Phe 
    530                 535                 540                 


Asp Glu Leu Val Pro Gln Asn Met Thr Pro Trp Glu Ile Pro Ile Thr 
545                 550                 555                 560 


Lys Asp Ile Asp Gly Leu Leu Ser Gln Ala Leu Leu Leu Gly Glu Leu 
                565                 570                 575     


Gly Pro Ala Val Glu Leu Cys Leu Lys Glu Glu Arg Phe Ala Asp Ala 
            580                 585                 590         


Ile Ile Leu Ala Gln Ala Gly Gly Thr Asp Leu Leu Lys Gln Thr Gln 
        595                 600                 605             


Glu Arg Tyr Leu Ala Lys Lys Lys Thr Lys Ile Ser Ser Leu Leu Ala 
    610                 615                 620                 


Cys Val Val Gln Lys Asn Trp Lys Asp Val Val Cys Thr Cys Ser Leu 
625                 630                 635                 640 


Lys Asn Trp Arg Glu Ala Leu Ala Leu Leu Leu Thr Tyr Ser Gly Thr 
                645                 650                 655     


Glu Lys Phe Pro Glu Leu Cys Asp Met Leu Gly Thr Arg Met Glu Gln 
            660                 665                 670         


Glu Gly Ser Arg Ala Leu Thr Ser Glu Ala Arg Leu Cys Tyr Val Cys 
        675                 680                 685             


Ser Gly Ser Val Glu Arg Leu Val Glu Cys Trp Ala Lys Cys His Gln 
    690                 695                 700                 


Ala Leu Ser Pro Met Ala Leu Gln Asp Leu Met Glu Lys Val Met Val 
705                 710                 715                 720 


Leu Asn Arg Ser Leu Glu Gln Leu Arg Gly Pro His Gly Val Ser Pro 
                725                 730                 735     


Gly Pro Ala Thr Thr Tyr Arg Val Thr Gln Tyr Ala Asn Leu Leu Ala 
            740                 745                 750         


Ala Gln Gly Ser Leu Ala Thr Ala Met Ser Phe Leu Pro Arg Asp Cys 
        755                 760                 765             


Ala Gln Pro Pro Val Gln Gln Leu Arg Asp Arg Leu Phe His Ala Gln 
    770                 775                 780                 


Gly Ser Ala Val Leu Gly Gln Gln Ser Pro Pro Phe Pro Phe Pro Arg 
785                 790                 795                 800 


Ile Val Val Gly Ala Thr Leu His Ser Lys Glu Thr Ser Ser Tyr Arg 
                805                 810                 815     


Leu Gly Ser Gln Pro Ser His Gln Val Pro Thr Pro Ser Pro Arg Pro 
            820                 825                 830         


Arg Val Phe Thr Pro Gln Ser Ser Pro Ala Met Pro Leu Ala Pro Ser 
        835                 840                 845             


His Pro Ser Pro Tyr Gln Gly Pro Arg Thr Gln Asn Ile Ser Asp Tyr 
    850                 855                 860                 


Arg Ala Pro Gly Pro Gln Ala Ile Gln Pro Leu Pro Leu Ser Pro Gly 
865                 870                 875                 880 


Val Arg Pro Ala Ser Ser Gln Pro Gln Leu Leu Gly Gly Gln Arg Val 
                885                 890                 895     


Gln Val Pro Asn Pro Val Gly Phe Pro Gly Thr Trp Pro Leu Pro Gly 
            900                 905                 910         


Ser Pro Leu Pro Met Ala Cys Pro Gly Ile Met Arg Pro Gly Ser Thr 
        915                 920                 925             


Ser Leu Pro Glu Thr Pro Arg Leu Phe Pro Leu Leu Pro Leu Arg Pro 
    930                 935                 940                 


Leu Gly Pro Gly Arg Met Val Ser His Thr Pro Ala Pro Pro Ala Ser 
945                 950                 955                 960 


Phe Pro Val Pro Tyr Leu Pro Gly Asp Pro Gly Ala Pro Cys Ser Ser 
                965                 970                 975     


Val Leu Pro Thr Thr Gly Ile Leu Thr Pro His Pro Gly Pro Gln Asp 
            980                 985                 990         


Ser Trp Lys Glu Ala Pro Ala Pro  Arg Gly Asn Leu Gln  Arg Asn Lys 
        995                 1000                 1005             


Leu Pro  Glu Thr Phe Met Pro  Pro Ala Pro Ile Thr  Ala Pro Val 
    1010                 1015                 1020             


Met Ser  Leu Thr Pro Glu Leu  Gln Gly Ile Leu Pro  Ser Gln Pro 
    1025                 1030                 1035             


Pro Val  Ser Ser Val Ser His  Ala Pro Pro Gly Val  Pro Gly Glu 
    1040                 1045                 1050             


Leu Ser  Leu Gln Leu Gln His  Leu Pro Pro Glu Lys  Met Glu Arg 
    1055                 1060                 1065             


Lys Glu  Leu Pro Pro Glu His  Gln Ser Leu Lys Ser  Ser Phe Glu 
    1070                 1075                 1080             


Ala Leu  Leu Gln Arg Cys Ser  Leu Ser Ala Thr Asp  Leu Lys Thr 
    1085                 1090                 1095             


Lys Arg  Lys Leu Glu Glu Ala  Ala Gln Arg Leu Glu  Tyr Leu Tyr 
    1100                 1105                 1110             


Glu Lys  Leu Cys Glu Gly Thr  Leu Ser Pro His Val  Val Ala Gly 
    1115                 1120                 1125             


Leu His  Glu Val Ala Arg Cys  Val Asp Ala Gly Ser  Phe Glu Gln 
    1130                 1135                 1140             


Gly Leu  Ala Val His Ala Gln  Val Ala Gly Cys Ser  Ser Phe Ser 
    1145                 1150                 1155             


Glu Val  Ser Ser Phe Met Pro  Ile Leu Lys Ala Val  Leu Ile Ile 
    1160                 1165                 1170             


Ala His  Lys Leu Leu Val 
    1175                 


<210> 6248
<211> 544
<212> PRT
<213> Homo sapiens

<400> 6248
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Cys Ser Gly Lys Tyr Ser Tyr Ser Leu His Pro Ser Leu Ile Ala 
    530                 535                 540                 


<210> 6249
<211> 562
<212> PRT
<213> Homo sapiens

<400> 6249
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Cys Met Tyr His Leu Gly Val Gly Leu Leu Asp Pro Ser Arg Ser 
    530                 535                 540                 


Phe Trp Ile Ala Ile Pro Trp Ala Cys Pro Gly Leu Gly Val Ala Ala 
545                 550                 555                 560 


Leu Cys 
        


<210> 6250
<211> 562
<212> PRT
<213> Homo sapiens

<400> 6250
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Cys Met Tyr His Leu Gly Val Gly Leu Leu Asp Pro Ser Arg Ser 
    530                 535                 540                 


Phe Trp Ile Ala Ile Pro Trp Ala Cys Pro Gly Leu Gly Val Ala Ala 
545                 550                 555                 560 


Leu Cys 
        


<210> 6251
<211> 423
<212> PRT
<213> Homo sapiens

<400> 6251
Met Glu Asp Lys Arg Ser Leu Ser Met Ala Arg Cys Glu Glu Arg Asn 
1               5                   10                  15      


Ser Arg Gly Gln Asp His Gly Leu Glu Arg Val Pro Phe Pro Pro Gln 
            20                  25                  30          


Leu Gln Ser Glu Thr Tyr Leu His Pro Ala Asp Pro Ser Pro Ala Trp 
        35                  40                  45              


Asp Asp Pro Gly Ser Thr Gly Ser Pro Asn Leu Arg Leu Leu Thr Glu 
    50                  55                  60                  


Glu Ile Ala Phe Gln Pro Leu Ala Glu Glu Ala Ser Phe Arg Arg Pro 
65                  70                  75                  80  


His Pro Asp Gly Asp Val Pro Pro Gln Gly Glu Asp Asn Leu Leu Ser 
                85                  90                  95      


Leu Pro Phe Pro Gln Lys Leu Trp Arg Leu Val Ser Ser Asn Gln Phe 
            100                 105                 110         


Ser Ser Ile Trp Trp Asp Asp Ser Gly Ala Cys Arg Val Ile Asn Gln 
        115                 120                 125             


Lys Leu Phe Glu Lys Glu Ile Leu Lys Arg Asp Val Ala His Lys Val 
    130                 135                 140                 


Phe Ala Thr Thr Ser Ile Lys Ser Phe Phe Arg Gln Leu Asn Leu Tyr 
145                 150                 155                 160 


Gly Phe Arg Lys Arg Arg Gln Cys Thr Phe Arg Thr Phe Thr Arg Ile 
                165                 170                 175     


Phe Ser Ala Lys Arg Leu Val Ser Ile Leu Asn Lys Leu Glu Phe Tyr 
            180                 185                 190         


Cys His Pro Tyr Phe Gln Arg Asp Ser Pro His Leu Leu Val Arg Met 
        195                 200                 205             


Lys Arg Arg Val Gly Val Lys Ser Ala Pro Arg His Gln Glu Glu Asp 
    210                 215                 220                 


Lys Pro Glu Ala Ala Gly Ser Cys Leu Ala Pro Ala Asp Thr Glu Gln 
225                 230                 235                 240 


Gln Asp His Thr Ser Pro Asn Glu Asn Asp Gln Val Thr Pro Gln His 
                245                 250                 255     


Arg Glu Pro Ala Gly Pro Asn Thr Gln Ile Arg Ser Gly Ser Ala Pro 
            260                 265                 270         


Pro Ala Thr Pro Val Met Val Pro Asp Ser Ala Val Ala Ser Asp Asn 
        275                 280                 285             


Ser Pro Val Thr Gln Pro Ala Gly Glu Trp Ser Glu Gly Ser Gln Ala 
    290                 295                 300                 


His Val Thr Pro Val Ala Ala Val Pro Gly Pro Ala Ala Leu Pro Phe 
305                 310                 315                 320 


Leu Tyr Val Pro Gly Ser Pro Thr Gln Met Asn Ser Tyr Gly Pro Val 
                325                 330                 335     


Val Ala Leu Pro Thr Ala Ser Arg Ser Thr Leu Ala Met Asp Thr Thr 
            340                 345                 350         


Gly Leu Pro Ala Pro Gly Met Leu Pro Phe Cys His Leu Trp Val Pro 
        355                 360                 365             


Val Thr Leu Val Ala Ala Gly Ala Ala Gln Pro Ala Ala Ser Met Val 
    370                 375                 380                 


Met Phe Pro His Leu Pro Ala Leu His His His Cys Pro His Ser His 
385                 390                 395                 400 


Arg Thr Ser Gln Tyr Met Pro Ala Ser Asp Gly Pro Gln Ala Tyr Pro 
                405                 410                 415     


Asp Tyr Ala Asp Gln Ser Thr 
            420             


<210> 6252
<211> 224
<212> PRT
<213> Homo sapiens

<400> 6252
Met Pro Thr Leu Phe Lys Gly Val Trp Gly Val Val Glu His Ser Arg 
1               5                   10                  15      


Ala Leu Gly Arg Phe Cys Pro Ala Cys Leu Pro Ser Gly Pro His Leu 
            20                  25                  30          


His Thr Gln Pro Ala Leu Gly Thr Ala Glu Met Thr Leu Leu Ser Ser 
        35                  40                  45              


Gln Ser Ser Ser Leu Val Ala Pro Ser Gly Ser Val Ser Ala Glu Asn 
    50                  55                  60                  


Pro Glu Gln Arg Met Leu Glu Lys Arg Ala Lys Val Ile Glu Glu Leu 
65                  70                  75                  80  


Leu Gln Thr Glu Arg Asp Tyr Ile Arg Asp Leu Glu Met Cys Ile Glu 
                85                  90                  95      


Arg Ile Met Val Pro Met Gln Gln Ala Gln Val Pro Asn Ile Asp Phe 
            100                 105                 110         


Glu Gly Leu Phe Gly Asn Met Gln Met Val Ile Lys Val Ser Lys Gln 
        115                 120                 125             


Leu Leu Ala Ala Leu Glu Ile Ser Asp Ala Val Gly Pro Val Phe Leu 
    130                 135                 140                 


Gly His Arg Asp Glu Leu Glu Gly Thr Tyr Lys Ile Tyr Cys Gln Asn 
145                 150                 155                 160 


His Asp Glu Ala Ile Ala Leu Leu Glu Ile Tyr Glu Lys Asp Glu Lys 
                165                 170                 175     


Ile Gln Lys His Leu Gln Asp Ser Leu Ala Asp Leu Asn Ser Leu Val 
            180                 185                 190         


Leu Lys Lys Gly Cys Thr Asn Tyr Ile Asn Leu Gly Ser Phe Leu Ile 
        195                 200                 205             


Lys Pro Val Gln Arg Val Met Arg Tyr Pro Leu Leu Leu Met Glu Leu 
    210                 215                 220                 


<210> 6253
<211> 625
<212> PRT
<213> Homo sapiens

<400> 6253
Met Arg Leu Pro Glu Arg His Gly Gly Pro Gln Gly Ser Leu Cys Leu 
1               5                   10                  15      


Met Asp Pro Cys Cys Pro Leu Ser Leu Ala Leu Gln Asp Leu Val Glu 
            20                  25                  30          


Arg Asp Cys Asn Gly Asp Thr Pro Asn Leu Ser Phe Tyr Arg Asn Glu 
        35                  40                  45              


Ile Arg Phe Leu Pro Asn Gly Cys Phe Ile Glu Asp Ile Leu Gln Asn 
    50                  55                  60                  


Trp Thr Asp Asn Tyr Asp Leu Leu Glu Asp Asn His Ser Tyr Ile Gln 
65                  70                  75                  80  


Trp Leu Phe Pro Leu Arg Glu Pro Gly Val Asn Trp His Ala Lys Pro 
                85                  90                  95      


Leu Thr Leu Arg Glu Val Glu Val Phe Lys Ser Ser Gln Glu Ile Gln 
            100                 105                 110         


Glu Arg Leu Val Arg Ala Tyr Glu Leu Met Leu Gly Phe Tyr Gly Ile 
        115                 120                 125             


Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg Ala Gln Asn Tyr 
    130                 135                 140                 


Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His Asn Asn Leu Arg 
145                 150                 155                 160 


Ile Thr Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Leu Glu His Phe 
                165                 170                 175     


Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr Leu Val Arg Arg 
            180                 185                 190         


Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr Phe Met Phe Ala 
        195                 200                 205             


Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His Phe Ala Trp Glu 
    210                 215                 220                 


His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro Gln Asp Lys Leu 
225                 230                 235                 240 


Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu Glu Gly Ser Arg 
                245                 250                 255     


Lys Val Glu Glu Glu Gly Ser Pro Gly Asp Pro Asp His Glu Ala Ser 
            260                 265                 270         


Thr Gln Gly Arg Thr Cys Gly Pro Glu His Ser Lys Gly Gly Gly Arg 
        275                 280                 285             


Val Asp Glu Gly Pro Gln Pro Arg Ser Val Glu Pro Gln Asp Ala Gly 
    290                 295                 300                 


Pro Leu Glu Arg Ser Gln Gly Asp Glu Ala Gly Gly His Gly Glu Asp 
305                 310                 315                 320 


Arg Pro Glu Pro Leu Ser Pro Lys Glu Ser Lys Lys Arg Lys Leu Glu 
                325                 330                 335     


Leu Ser Arg Arg Glu Gln Pro Pro Thr Glu Pro Gly Pro Gln Ser Ala 
            340                 345                 350         


Ser Glu Val Glu Lys Ile Ala Leu Asn Leu Glu Gly Cys Ala Leu Ser 
        355                 360                 365             


Gln Gly Ser Leu Arg Thr Gly Thr Gln Glu Val Gly Gly Gln Asp Pro 
    370                 375                 380                 


Gly Glu Ala Val Gln Pro Cys Arg Gln Pro Leu Gly Ala Arg Val Ala 
385                 390                 395                 400 


Asp Lys Val Arg Lys Arg Arg Lys Val Asp Glu Gly Ala Gly Asp Ser 
                405                 410                 415     


Ala Ala Val Ala Ser Gly Gly Ala Gln Thr Leu Ala Leu Ala Gly Ser 
            420                 425                 430         


Pro Ala Pro Ser Gly His Pro Lys Ala Gly His Ser Glu Asn Gly Val 
        435                 440                 445             


Glu Glu Asp Thr Glu Gly Arg Thr Gly Pro Lys Glu Gly Thr Pro Gly 
    450                 455                 460                 


Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly Pro Ala Gly Asp 
465                 470                 475                 480 


Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly 
                485                 490                 495     


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
            500                 505                 510         


Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu 
        515                 520                 525             


Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Glu 
    530                 535                 540                 


Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly Pro Ala Gly Asp 
545                 550                 555                 560 


Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly 
                565                 570                 575     


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
            580                 585                 590         


Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Lys Ala Gly Glu Ala 
        595                 600                 605             


Ala Glu Leu Gln Asp Ala Glu Val Glu Ser Ser Ala Lys Ser Gly Lys 
    610                 615                 620                 


Pro 
625 


<210> 6254
<211> 461
<212> PRT
<213> Homo sapiens

<400> 6254
Met Asp Asp Pro Asp Cys Asp Ser Thr Trp Glu Glu Asp Glu Glu Asp 
1               5                   10                  15      


Ala Glu Asp Ala Glu Asp Glu Asp Cys Glu Asp Gly Glu Ala Ala Gly 
            20                  25                  30          


Ala Arg Asp Ala Asp Ala Gly Asp Glu Asp Glu Glu Ser Glu Glu Pro 
        35                  40                  45              


Arg Ala Ala Arg Pro Ser Ser Phe Gln Ser Arg Met Thr Gly Ser Arg 
    50                  55                  60                  


Asn Trp Arg Ala Thr Arg Asp Met Cys Arg Tyr Arg His Asn Tyr Pro 
65                  70                  75                  80  


Asp Leu Val Glu Arg Asp Cys Asn Gly Asp Thr Pro Asn Leu Ser Phe 
                85                  90                  95      


Tyr Arg Asn Glu Ile Arg Phe Leu Pro Asn Gly Cys Phe Ile Glu Asp 
            100                 105                 110         


Ile Leu Gln Asn Trp Thr Asp Asn Tyr Asp Leu Leu Glu Asp Asn His 
        115                 120                 125             


Ser Tyr Ile Gln Trp Leu Phe Pro Leu Arg Glu Pro Gly Val Asn Trp 
    130                 135                 140                 


His Ala Lys Pro Leu Thr Leu Arg Glu Val Glu Val Phe Lys Ser Ser 
145                 150                 155                 160 


Gln Glu Ile Gln Glu Arg Leu Val Arg Ala Tyr Glu Leu Met Leu Gly 
                165                 170                 175     


Phe Tyr Gly Ile Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg 
            180                 185                 190         


Ala Gln Asn Tyr Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His 
        195                 200                 205             


Asn Asn Leu Arg Ile Thr Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly 
    210                 215                 220                 


Leu Glu His Phe Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr 
225                 230                 235                 240 


Leu Val Arg Arg Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr 
                245                 250                 255     


Phe Met Phe Ala Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His 
            260                 265                 270         


Phe Ala Trp Glu His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro 
        275                 280                 285             


Gln Asp Lys Leu Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu 
    290                 295                 300                 


Glu Gly Ser Arg Lys Val Glu Glu Glu Gly Ser Pro Gly Asp Pro Asp 
305                 310                 315                 320 


His Glu Ala Ser Thr Gln Gly Arg Thr Cys Gly Pro Glu His Ser Lys 
                325                 330                 335     


Gly Gly Gly Arg Val Asp Glu Gly Pro Gln Pro Arg Ser Val Glu Pro 
            340                 345                 350         


Gln Asp Ala Gly Pro Leu Glu Arg Ser Gln Gly Asp Glu Ala Gly Gly 
        355                 360                 365             


His Gly Glu Asp Arg Pro Glu Pro Leu Ser Pro Lys Glu Ser Lys Lys 
    370                 375                 380                 


Arg Lys Leu Glu Leu Ser Arg Arg Glu Gln Pro Pro Thr Glu Pro Gly 
385                 390                 395                 400 


Pro Gln Ser Ala Ser Glu Val Glu Lys Ile Ala Leu Asn Leu Glu Gly 
                405                 410                 415     


Cys Ala Leu Ser Gln Gly Ser Leu Arg Thr Gly Thr Gln Glu Val Gly 
            420                 425                 430         


Gly Gln Asp Pro Gly Glu Ser Ser Cys Pro Cys Cys Arg Gly Trp Gly 
        435                 440                 445             


Leu Arg Ser Cys Cys Gly Leu Pro Ser Gly Ser Ala Ser 
    450                 455                 460     


<210> 6255
<211> 512
<212> PRT
<213> Homo sapiens

<400> 6255
Met Pro Ser Pro Ser Arg Ser Gly Arg Ser Arg Cys Leu Lys Ala Pro 
1               5                   10                  15      


Arg Arg Ser Arg Ser Gly Leu Ser Gly Pro Thr Ser Ser Cys Trp Ala 
            20                  25                  30          


Ser Thr Ile Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg Ala 
        35                  40                  45              


Gln Asn Tyr Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His Asn 
    50                  55                  60                  


Asn Leu Arg Ile Thr Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Leu 
65                  70                  75                  80  


Glu His Phe Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr Leu 
                85                  90                  95      


Val Arg Arg Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr Phe 
            100                 105                 110         


Met Phe Ala Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His Phe 
        115                 120                 125             


Ala Trp Glu His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro Gln 
    130                 135                 140                 


Asp Lys Leu Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu Glu 
145                 150                 155                 160 


Gly Ser Arg Lys Val Glu Glu Glu Gly Ser Pro Gly Asp Pro Asp His 
                165                 170                 175     


Glu Ala Ser Thr Gln Gly Arg Thr Cys Gly Pro Glu His Ser Lys Gly 
            180                 185                 190         


Gly Gly Arg Val Asp Glu Gly Pro Gln Pro Arg Ser Val Glu Pro Gln 
        195                 200                 205             


Asp Ala Gly Pro Leu Glu Arg Ser Gln Gly Asp Glu Ala Gly Gly His 
    210                 215                 220                 


Gly Glu Asp Arg Pro Glu Pro Leu Ser Pro Lys Glu Ser Lys Lys Arg 
225                 230                 235                 240 


Lys Leu Glu Leu Ser Arg Arg Glu Gln Pro Pro Thr Glu Pro Gly Pro 
                245                 250                 255     


Gln Ser Ala Ser Glu Val Glu Lys Ile Ala Leu Asn Leu Glu Gly Cys 
            260                 265                 270         


Ala Leu Ser Gln Gly Ser Leu Arg Thr Gly Thr Gln Glu Val Gly Gly 
        275                 280                 285             


Gln Asp Pro Gly Glu Ala Val Gln Pro Cys Arg Gln Pro Leu Gly Ala 
    290                 295                 300                 


Arg Val Ala Asp Lys Val Arg Lys Arg Arg Lys Val Asp Glu Gly Ala 
305                 310                 315                 320 


Gly Asp Ser Ala Ala Val Ala Ser Gly Gly Ala Gln Thr Leu Ala Leu 
                325                 330                 335     


Ala Gly Ser Pro Ala Pro Ser Gly His Pro Lys Ala Gly His Ser Glu 
            340                 345                 350         


Asn Gly Val Glu Glu Asp Thr Glu Gly Arg Thr Gly Pro Lys Glu Gly 
        355                 360                 365             


Thr Pro Gly Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr 
                405                 410                 415     


Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Glu Ser 
            420                 425                 430         


Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly Pro Ala Gly Asp Glu 
        435                 440                 445             


Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly Pro 
    450                 455                 460                 


Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Ser 
465                 470                 475                 480 


Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Lys Ala Gly Glu Ala Ala 
                485                 490                 495     


Glu Leu Gln Asp Ala Glu Val Glu Ser Ser Ala Lys Ser Gly Lys Pro 
            500                 505                 510         


<210> 6256
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6256
Met Gly Gln Gln Ser Ser Val Arg Arg Leu Lys Arg Ser Val Pro Cys 
1               5                   10                  15      


Glu Ser Asn Glu Ala Asn Glu Ala Asn Glu Ala Asn Lys Thr Met Pro 
            20                  25                  30          


Glu Thr Pro Thr Gly Asp Ser Asp Pro Gln Pro Ala Pro Lys Lys Met 
        35                  40                  45              


Lys Thr Ser Glu Ser Ser Thr Ile Leu Val Val Arg Tyr Arg Arg Asn 
    50                  55                  60                  


Val Lys Arg Thr Ser Pro Glu Glu Leu Val Asn Asp His Ala Arg Glu 
65                  70                  75                  80  


Asn Arg Ile Asn Pro Asp Gln Met Glu Glu Glu Glu Phe Ile Glu Ile 
                85                  90                  95      


Thr Thr Glu Arg Pro Lys Lys 
            100             


<210> 6257
<211> 591
<212> PRT
<213> Homo sapiens

<400> 6257
Met Glu Lys Ala Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys 
1               5                   10                  15      


His Leu Lys Thr Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser 
            20                  25                  30          


Glu Ser His Leu Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr 
        35                  40                  45              


Glu Leu Glu Ala Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val 
    50                  55                  60                  


Glu Leu Leu Leu Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe 
65                  70                  75                  80  


Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ile Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Glu His Leu Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn 
        115                 120                 125             


Leu Ser Ser Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn 
    130                 135                 140                 


Thr Asn Leu Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn 
                165                 170                 175     


Arg Phe Ser Gln Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln 
            180                 185                 190         


Ile His Lys Arg Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys 
        195                 200                 205             


Ser Leu Glu Thr Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn 
    210                 215                 220                 


Lys Asn Glu Ala Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val 
225                 230                 235                 240 


Ala Leu Lys Lys Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe 
                245                 250                 255     


Thr Gly Ala Ile Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala 
            260                 265                 270         


Lys Leu Ser Glu Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr 
        275                 280                 285             


Glu Lys Ile Val Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr 
    290                 295                 300                 


Met Lys Lys Gln Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu 
305                 310                 315                 320 


Asp His Gly Lys Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser 
                325                 330                 335     


Ile Glu Tyr Glu Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys 
            340                 345                 350         


Thr Thr Leu Ala Ala Leu Lys Asp Glu Val Val Ser Val Glu Asn Glu 
        355                 360                 365             


Leu Ser Glu Leu Gln Glu Val Glu Lys Lys Gln Lys Thr Leu Ile Glu 
    370                 375                 380                 


Met Tyr Lys Thr Gln Val Gln Lys Leu Gln Glu Ala Ala Glu Ile Val 
385                 390                 395                 400 


Lys Ser Arg Cys Glu Asn Leu Leu His Lys Asn Asn Gln Ile Thr Lys 
                405                 410                 415     


Thr Lys Asn Lys Asn Val Glu Lys Val Asp Gly Asn His Asn Leu Leu 
            420                 425                 430         


Thr Lys Leu Ser Leu Glu Glu Glu Asn Cys Leu Ile Gln Leu Lys Cys 
        435                 440                 445             


Glu Asn Leu Gln Gln Lys Leu Glu Gln Met Asp Ala Glu Asn Lys Glu 
    450                 455                 460                 


Leu Glu Lys Lys Leu Ala Asn Gln Glu Glu Cys Leu Lys His Ser Asn 
465                 470                 475                 480 


Leu Lys Phe Lys Glu Lys Ser Ala Glu Tyr Thr Ala Leu Ala Arg Gln 
                485                 490                 495     


Leu Glu Ala Ala Leu Glu Glu Gly Arg Gln Lys Val Ala Glu Glu Ile 
            500                 505                 510         


Glu Lys Met Ser Ser Arg Glu Ser Ala Leu Gln Ile Lys Ile Leu Asp 
        515                 520                 525             


Leu Glu Thr Glu Leu Arg Lys Lys Asn Glu Glu Gln Asn Gln Leu Val 
    530                 535                 540                 


Cys Lys Met Asn Ser Lys Ala Gln His Gln Glu Val Cys Leu Lys Glu 
545                 550                 555                 560 


Val Gln Asn Ser Leu Glu Lys Ser Glu Asn Gln Asn Glu Ser Ile Lys 
                565                 570                 575     


Asn Tyr Leu Gln Phe Leu Lys Thr Ser Tyr Val Thr Met Phe Glu 
            580                 585                 590     


<210> 6258
<211> 644
<212> PRT
<213> Homo sapiens

<400> 6258
Met Glu Lys Ala Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys 
1               5                   10                  15      


His Leu Lys Thr Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser 
            20                  25                  30          


Glu Ser His Leu Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr 
        35                  40                  45              


Glu Leu Glu Ala Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val 
    50                  55                  60                  


Glu Leu Leu Leu Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe 
65                  70                  75                  80  


Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ile Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Glu His Leu Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn 
        115                 120                 125             


Leu Ser Ser Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn 
    130                 135                 140                 


Thr Asn Leu Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn 
                165                 170                 175     


Arg Phe Ser Gln Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln 
            180                 185                 190         


Ile His Lys Arg Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys 
        195                 200                 205             


Ser Leu Glu Thr Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn 
    210                 215                 220                 


Lys Asn Glu Ala Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val 
225                 230                 235                 240 


Ala Leu Lys Lys Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe 
                245                 250                 255     


Thr Gly Ala Ile Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala 
            260                 265                 270         


Lys Leu Ser Glu Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr 
        275                 280                 285             


Glu Lys Ile Val Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr 
    290                 295                 300                 


Met Lys Lys Gln Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu 
305                 310                 315                 320 


Asp His Gly Lys Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser 
                325                 330                 335     


Ile Glu Tyr Glu Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys 
            340                 345                 350         


Thr Thr Leu Ala Ala Leu Lys Asp Glu Val Val Ser Val Glu Asn Glu 
        355                 360                 365             


Leu Ser Glu Leu Gln Glu Val Glu Lys Lys Gln Lys Thr Leu Ile Glu 
    370                 375                 380                 


Met Tyr Lys Thr Gln Val Gln Lys Leu Gln Glu Ala Ala Glu Ile Val 
385                 390                 395                 400 


Lys Ser Arg Cys Glu Asn Leu Leu His Lys Asn Asn Gln Ile Thr Lys 
                405                 410                 415     


Thr Lys Asn Lys Asn Val Glu Lys Met Arg Gly Gln Met Glu Ser His 
            420                 425                 430         


Leu Lys Glu Leu Glu Arg Val Cys Asp Ser Leu Thr Ala Ala Glu Arg 
        435                 440                 445             


Arg Leu His Glu Cys Gln Glu Ser Leu Gln Cys Cys Lys Gly Lys Cys 
    450                 455                 460                 


Ala Asp Gln Glu His Thr Ile Arg Glu Leu Gln Gly Gln Val Asp Gly 
465                 470                 475                 480 


Asn His Asn Leu Leu Thr Lys Leu Ser Leu Glu Glu Glu Asn Cys Leu 
                485                 490                 495     


Ile Gln Leu Lys Cys Glu Asn Leu Gln Gln Lys Leu Glu Gln Met Asp 
            500                 505                 510         


Ala Glu Asn Lys Glu Leu Glu Lys Lys Leu Ala Asn Gln Glu Glu Cys 
        515                 520                 525             


Leu Lys His Ser Asn Leu Lys Phe Lys Glu Lys Ser Ala Glu Tyr Thr 
    530                 535                 540                 


Ala Leu Ala Arg Gln Leu Glu Ala Ala Leu Glu Glu Gly Arg Gln Lys 
545                 550                 555                 560 


Val Ala Glu Glu Ile Glu Lys Met Ser Ser Arg Glu Ser Ala Leu Gln 
                565                 570                 575     


Ile Lys Ile Leu Asp Leu Glu Thr Glu Leu Arg Lys Lys Asn Glu Glu 
            580                 585                 590         


Gln Asn Gln Leu Val Cys Lys Met Asn Ser Lys Ala Gln His Gln Glu 
        595                 600                 605             


Val Cys Leu Lys Glu Val Gln Asn Ser Leu Glu Lys Ser Glu Asn Gln 
    610                 615                 620                 


Asn Glu Ser Ile Lys Asn Tyr Leu Gln Phe Leu Lys Thr Ser Tyr Val 
625                 630                 635                 640 


Thr Met Phe Glu 
                


<210> 6259
<211> 841
<212> PRT
<213> Homo sapiens

<400> 6259
Met Met Ala Asp Gly Ala Ala Ala Gly Ala Gly Gly Ser Pro Ser Leu 
1               5                   10                  15      


Arg Glu Leu Arg Ala Arg Met Val Ala Ala Ala Asn Glu Ile Ala Lys 
            20                  25                  30          


Glu Arg Arg Lys Gln Asp Val Val Asn Arg Val Ala Thr His Ser Ser 
        35                  40                  45              


Asn Ile Arg Ser Thr Phe Lys Pro Val Ile Asp Gly Ser Met Leu Lys 
    50                  55                  60                  


Asn Asp Ile Lys Gln Arg Leu Ala Arg Glu Arg Arg Glu Glu Lys Arg 
65                  70                  75                  80  


Arg Gln Gln Asp Ala Asn Lys Glu Thr Gln Leu Leu Glu Lys Glu Arg 
                85                  90                  95      


Lys Thr Lys Leu Gln Tyr Glu Lys Gln Met Glu Glu Arg Gln Arg Lys 
            100                 105                 110         


Leu Lys Glu Arg Lys Glu Lys Glu Glu Gln Arg Arg Ile Ala Ala Glu 
        115                 120                 125             


Glu Lys Arg His Gln Lys Asp Glu Ala Gln Lys Glu Lys Phe Thr Ala 
    130                 135                 140                 


Ile Leu Tyr Arg Thr Leu Glu Arg Arg Arg Leu Ala Asp Asp Tyr Gln 
145                 150                 155                 160 


Gln Lys Arg Trp Ser Trp Gly Gly Ser Ala Met Ala Asn Ser Glu Ser 
                165                 170                 175     


Lys Thr Gly Lys Thr Asp Lys Glu Arg Ser Ser Ser Leu Asn Arg Arg 
            180                 185                 190         


Asp Ser Asn Leu His Ser Ser Thr Asp Lys Glu Gln Ala Glu Arg Lys 
        195                 200                 205             


Pro Arg Val Thr Gly Val Thr Asn Tyr Val Met Gln Tyr Val Thr Val 
    210                 215                 220                 


Pro Leu Arg Lys Cys Thr Ser Asp Glu Leu Arg Ala Val Met Phe Pro 
225                 230                 235                 240 


Met Ser Thr Met Lys Ile Pro Pro Gln Thr Lys Val Glu Glu Ser Pro 
                245                 250                 255     


Leu Glu Lys Val Glu Thr Pro Pro Lys Ala Ser Val Asp Ala Pro Pro 
            260                 265                 270         


Gln Val Asn Val Glu Val Phe Cys Asn Thr Ser Met Glu Ala Ser Pro 
        275                 280                 285             


Lys Ala Gly Val Gly Met Ala Pro Glu Val Ser Thr Asp Ser Phe Pro 
    290                 295                 300                 


Val Val Ser Val Asp Val Ser Pro Val Val Ser Thr Tyr Asp Ser Glu 
305                 310                 315                 320 


Met Ser Met Asp Ala Ser Pro Glu Leu Ser Ile Glu Ala Leu Pro Lys 
                325                 330                 335     


Val Asp Leu Glu Thr Val Pro Lys Val Ser Ile Val Ala Ser Pro Glu 
            340                 345                 350         


Ala Ser Leu Glu Ala Pro Pro Glu Val Ser Leu Glu Ala Leu Pro Glu 
        355                 360                 365             


Val Ser Val Glu Ala Ala Pro Glu Gly Ser Leu Glu Ala Pro Pro Lys 
    370                 375                 380                 


Gly Ser Ala Glu Val Ala Pro Lys Glu Ser Val Lys Gly Ser Pro Lys 
385                 390                 395                 400 


Glu Ser Met Glu Ala Ser Pro Glu Ala Met Val Lys Ala Ser Pro Lys 
                405                 410                 415     


Thr Ser Leu Glu Ala Ser Met Glu Ala Ser Pro Lys Ala Lys Ala Arg 
            420                 425                 430         


Asp Ala Pro Lys Lys Ser Glu Met Asp Lys Gln Ala Leu Ile Pro Ile 
        435                 440                 445             


Ala Lys Lys Arg Leu Ser Ser Tyr Thr Glu Cys Tyr Lys Trp Ser Ser 
    450                 455                 460                 


Ser Pro Glu Asn Ala Cys Gly Leu Pro Ser Pro Ile Ser Thr Asn Arg 
465                 470                 475                 480 


Gln Ile Gln Lys Asn Cys Pro Pro Ser Pro Leu Pro Leu Ile Ser Lys 
                485                 490                 495     


Gln Ser Pro Gln Thr Ser Phe Pro Tyr Lys Ile Met Pro Ile Gln His 
            500                 505                 510         


Thr Leu Ser Val Gln Ser Ala Ser Ser Thr Val Lys Lys Lys Lys Glu 
        515                 520                 525             


Thr Val Ser Lys Thr Thr Asn Arg Cys Glu Ala Leu Ser Gln Arg His 
    530                 535                 540                 


Met Ile Tyr Glu Glu Ser Gly Asn Lys Ser Thr Ala Gly Ile Met Asn 
545                 550                 555                 560 


Ala Glu Ala Ala Thr Lys Ile Leu Thr Glu Leu Arg Arg Leu Ala Arg 
                565                 570                 575     


Glu Gln Arg Glu Lys Glu Glu Glu Glu Arg Gln Arg Glu Glu Met Gln 
            580                 585                 590         


Gln Arg Val Ile Lys Lys Ser Lys Asp Met Ala Lys Glu Ala Val Gly 
        595                 600                 605             


Gly Gln Ala Glu Asp His Leu Lys Leu Lys Asp Gly Gln Gln Gln Asn 
    610                 615                 620                 


Glu Thr Lys Lys Lys Lys Gly Trp Leu Asp Gln Glu Asp Gln Glu Ala 
625                 630                 635                 640 


Pro Leu Gln Lys Gly Asp Ala Lys Ile Lys Ala Gln Glu Glu Ala Asp 
                645                 650                 655     


Lys Arg Lys Lys Glu His Glu Arg Ile Met Leu Gln Asn Leu Gln Glu 
            660                 665                 670         


Arg Leu Glu Arg Lys Lys Arg Ile Glu Glu Ile Met Lys Arg Thr Arg 
        675                 680                 685             


Lys Thr Asp Val Asn Ala Ser Lys Val Thr Glu Thr Ser Ser His Asp 
    690                 695                 700                 


Ile Tyr Glu Glu Ala Glu Ala Asp Asn Glu Glu Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Leu Asn Glu Met Phe Pro Ser Ala Ile Leu Asn Gly Thr Gly Ser Pro 
                725                 730                 735     


Thr Lys Phe Lys Met Pro Phe Asn Asn Ala Lys Lys Met Thr His Lys 
            740                 745                 750         


Leu Val Phe Leu Glu Asp Gly Thr Ser Gln Val Arg Lys Glu Pro Lys 
        755                 760                 765             


Thr Tyr Phe Asn Gly Asp Leu Lys Asn Phe Arg Gln Lys Ser Met Lys 
    770                 775                 780                 


Asp Thr Ser Ile Gln Glu Val Val Ser Arg Pro Ser Ser Lys Arg Met 
785                 790                 795                 800 


Thr Ser His Thr Thr Lys Thr Arg Lys Ala Asp Glu Thr Asn Thr Thr 
                805                 810                 815     


Ser Arg Ser Ser Ala Gln Thr Lys Ser Glu Gly Phe His Asp Ile Leu 
            820                 825                 830         


Pro Lys Ser Ser Asp Thr Phe Arg Gln 
        835                 840     


<210> 6260
<211> 858
<212> PRT
<213> Homo sapiens

<400> 6260
Met Thr Ser Pro Arg Val Ala Ala Ala Asn Glu Ile Ala Lys Glu Arg 
1               5                   10                  15      


Arg Lys Gln Asp Val Val Asn Arg Val Ala Thr His Ser Ser Asn Ile 
            20                  25                  30          


Arg Ser Thr Phe Lys Pro Val Ile Asp Gly Ser Met Leu Lys Asn Asp 
        35                  40                  45              


Ile Lys Gln Arg Leu Ala Arg Glu Arg Arg Glu Glu Lys Arg Arg Gln 
    50                  55                  60                  


Gln Asp Ala Asn Lys Glu Thr Gln Leu Leu Glu Lys Glu Arg Lys Thr 
65                  70                  75                  80  


Lys Leu Gln Tyr Glu Lys Gln Met Glu Glu Arg Gln Arg Lys Leu Lys 
                85                  90                  95      


Glu Arg Lys Glu Lys Glu Glu Gln Arg Arg Ile Ala Ala Glu Glu Lys 
            100                 105                 110         


Arg His Gln Lys Asp Glu Ala Gln Lys Glu Lys Phe Thr Ala Ile Leu 
        115                 120                 125             


Tyr Arg Thr Leu Glu Arg Arg Arg Leu Ala Asp Asp Tyr Gln Gln Lys 
    130                 135                 140                 


Arg Trp Ser Trp Gly Gly Ser Ala Met Ala Asn Ser Glu Ser Lys Thr 
145                 150                 155                 160 


Ala Asn Lys Arg Ser Ala Ser Thr Glu Lys Leu Glu Gln Gly Thr Ser 
                165                 170                 175     


Ala Leu Ile Arg Gln Met Pro Leu Ser Ser Ala Gly Leu Gln Asn Ser 
            180                 185                 190         


Val Ala Lys Arg Lys Thr Asp Lys Glu Arg Ser Ser Ser Leu Asn Arg 
        195                 200                 205             


Arg Asp Ser Asn Leu His Ser Ser Thr Asp Lys Glu Gln Ala Glu Arg 
    210                 215                 220                 


Lys Pro Arg Val Thr Gly Val Thr Asn Tyr Val Met Gln Tyr Val Thr 
225                 230                 235                 240 


Val Pro Leu Arg Lys Cys Thr Ser Asp Glu Leu Arg Ala Val Met Phe 
                245                 250                 255     


Pro Met Ser Thr Met Lys Ile Pro Pro Gln Thr Lys Val Glu Glu Ser 
            260                 265                 270         


Pro Leu Glu Lys Val Glu Thr Pro Pro Lys Ala Ser Val Asp Ala Pro 
        275                 280                 285             


Pro Gln Val Asn Val Glu Val Phe Cys Asn Thr Ser Met Glu Ala Ser 
    290                 295                 300                 


Pro Lys Ala Gly Val Gly Met Ala Pro Glu Val Ser Thr Asp Ser Phe 
305                 310                 315                 320 


Pro Val Val Ser Val Asp Val Ser Pro Val Val Ser Thr Tyr Asp Ser 
                325                 330                 335     


Glu Met Ser Met Asp Ala Ser Pro Glu Leu Ser Ile Glu Ala Leu Pro 
            340                 345                 350         


Lys Val Asp Leu Glu Thr Val Pro Lys Val Ser Ile Val Ala Ser Pro 
        355                 360                 365             


Glu Ala Ser Leu Glu Ala Pro Pro Glu Val Ser Leu Glu Ala Leu Pro 
    370                 375                 380                 


Glu Val Ser Val Glu Ala Ala Pro Glu Gly Ser Leu Glu Ala Pro Pro 
385                 390                 395                 400 


Lys Gly Ser Ala Glu Val Ala Pro Lys Glu Ser Val Lys Gly Ser Pro 
                405                 410                 415     


Lys Glu Ser Met Glu Ala Ser Pro Glu Ala Met Val Lys Ala Ser Pro 
            420                 425                 430         


Lys Thr Ser Leu Glu Ala Ser Met Glu Ala Ser Pro Lys Ala Lys Ala 
        435                 440                 445             


Arg Asp Ala Pro Lys Lys Ser Glu Met Asp Lys Gln Ala Leu Ile Pro 
    450                 455                 460                 


Ile Ala Lys Lys Arg Leu Ser Ser Tyr Thr Glu Cys Tyr Lys Trp Ser 
465                 470                 475                 480 


Ser Ser Pro Glu Asn Ala Cys Gly Leu Pro Ser Pro Ile Ser Thr Asn 
                485                 490                 495     


Arg Gln Ile Gln Lys Asn Cys Pro Pro Ser Pro Leu Pro Leu Ile Ser 
            500                 505                 510         


Lys Gln Ser Pro Gln Thr Ser Phe Pro Tyr Lys Ile Met Pro Ile Gln 
        515                 520                 525             


His Thr Leu Ser Val Gln Ser Ala Ser Ser Thr Val Lys Lys Lys Lys 
    530                 535                 540                 


Glu Thr Val Ser Lys Thr Thr Asn Arg Cys Glu Ala Leu Ser Gln Arg 
545                 550                 555                 560 


His Met Ile Tyr Glu Glu Ser Gly Asn Lys Ser Thr Ala Gly Ile Met 
                565                 570                 575     


Asn Ala Glu Ala Ala Thr Lys Ile Leu Thr Glu Leu Arg Arg Leu Ala 
            580                 585                 590         


Arg Glu Gln Arg Glu Lys Glu Glu Glu Glu Arg Gln Arg Glu Glu Met 
        595                 600                 605             


Gln Gln Arg Val Ile Lys Lys Ser Lys Asp Met Ala Lys Glu Ala Val 
    610                 615                 620                 


Gly Gly Gln Ala Glu Asp His Leu Lys Leu Lys Asp Gly Gln Gln Gln 
625                 630                 635                 640 


Asn Glu Thr Lys Lys Lys Lys Gly Trp Leu Asp Gln Glu Asp Gln Glu 
                645                 650                 655     


Ala Pro Leu Gln Lys Gly Asp Ala Lys Ile Lys Ala Gln Glu Glu Ala 
            660                 665                 670         


Asp Lys Arg Lys Lys Glu His Glu Arg Ile Met Leu Gln Asn Leu Gln 
        675                 680                 685             


Glu Arg Leu Glu Arg Lys Lys Arg Ile Glu Glu Ile Met Lys Arg Thr 
    690                 695                 700                 


Arg Lys Thr Asp Val Asn Ala Ser Lys Val Thr Glu Thr Ser Ser His 
705                 710                 715                 720 


Asp Ile Tyr Glu Glu Ala Glu Ala Asp Asn Glu Glu Ser Asp Lys Asp 
                725                 730                 735     


Ser Leu Asn Glu Met Phe Pro Ser Ala Ile Leu Asn Gly Thr Gly Ser 
            740                 745                 750         


Pro Thr Lys Phe Lys Met Pro Phe Asn Asn Ala Lys Lys Met Thr His 
        755                 760                 765             


Lys Leu Val Phe Leu Glu Asp Gly Thr Ser Gln Val Arg Lys Glu Pro 
    770                 775                 780                 


Lys Thr Tyr Phe Asn Gly Asp Leu Lys Asn Phe Arg Gln Lys Ser Met 
785                 790                 795                 800 


Lys Asp Thr Ser Ile Gln Glu Val Val Ser Arg Pro Ser Ser Lys Arg 
                805                 810                 815     


Met Thr Ser His Thr Thr Lys Thr Arg Lys Ala Asp Glu Thr Asn Thr 
            820                 825                 830         


Thr Ser Arg Ser Ser Ala Gln Thr Lys Ser Glu Gly Phe His Asp Ile 
        835                 840                 845             


Leu Pro Lys Ser Ser Asp Thr Phe Arg Gln 
    850                 855             


<210> 6261
<211> 315
<212> PRT
<213> Homo sapiens

<400> 6261
Met Pro Leu Lys Leu Arg Gly Lys Lys Lys Ala Lys Ser Lys Glu Thr 
1               5                   10                  15      


Ala Gly Leu Val Glu Gly Glu Pro Thr Gly Ala Gly Gly Gly Ser Leu 
            20                  25                  30          


Ser Ala Ser Arg Ala Pro Ala Arg Arg Leu Val Phe His Ala Gln Leu 
        35                  40                  45              


Ala His Gly Ser Ala Thr Gly Arg Val Glu Gly Phe Ser Ser Ile Gln 
    50                  55                  60                  


Glu Leu Tyr Ala Gln Ile Ala Gly Ala Phe Glu Ile Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Leu Tyr Cys Thr Leu Asn Thr Pro Lys Ile Asp Met Glu Arg Leu 
                85                  90                  95      


Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
            100                 105                 110         


Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu Asp Ser Leu Gly 
        115                 120                 125             


Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe Ile Lys Arg Ile 
    130                 135                 140                 


Lys Asp Gly Gly Val Ile Asp Ser Val Lys Thr Ile Cys Val Gly Asp 
145                 150                 155                 160 


His Ile Glu Ser Ile Asn Gly Glu Asn Ile Val Gly Trp Arg His Tyr 
                165                 170                 175     


Asp Val Ala Lys Lys Leu Lys Glu Leu Lys Lys Glu Glu Leu Phe Thr 
            180                 185                 190         


Met Lys Leu Ile Glu Pro Lys Lys Ala Phe Glu Ile Glu Leu Arg Ser 
        195                 200                 205             


Lys Ala Gly Lys Ser Ser Gly Glu Lys Ile Gly Cys Gly Arg Ala Thr 
    210                 215                 220                 


Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr Val Glu Glu Met Pro Ser 
225                 230                 235                 240 


Glu Thr Lys Ala Lys Ala Ile Glu Lys Ile Asp Asp Val Leu Glu Leu 
                245                 250                 255     


Tyr Met Gly Ile Arg Asp Ile Asp Leu Ala Thr Thr Met Phe Glu Ala 
            260                 265                 270         


Gly Lys Asp Lys Val Asn Pro Asp Glu Phe Ala Val Ala Leu Asp Glu 
        275                 280                 285             


Thr Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp Val Trp 
    290                 295                 300                 


Gly Val Ile Gly Asp Ala Lys Arg Arg Gly Leu 
305                 310                 315 


<210> 6262
<211> 828
<212> PRT
<213> Homo sapiens

<400> 6262
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg Val 
            100                 105                 110         


Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu Gly 
        115                 120                 125             


Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln Glu 
    130                 135                 140                 


Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys Thr 
145                 150                 155                 160 


Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu Glu 
                165                 170                 175     


Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn 
            180                 185                 190         


Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro 
        195                 200                 205             


Leu Thr Gln Phe Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys 
    210                 215                 220                 


Lys Pro Ala Ile Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp 
225                 230                 235                 240 


His Lys Ser Arg Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly 
                245                 250                 255     


Ile Lys Thr Val Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala 
            260                 265                 270         


Gln Glu Phe Leu Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys 
        275                 280                 285             


Glu Gln Val Met Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu 
    290                 295                 300                 


Glu Thr Met Glu Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser 
305                 310                 315                 320 


Cys Glu Ser Cys Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser 
                325                 330                 335     


Arg Cys Phe Ser Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp 
            340                 345                 350         


Asp Glu Asn Asn Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met 
        355                 360                 365             


Cys Asn Lys Ile Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp 
    370                 375                 380                 


Arg Asp Ser Ile Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val 
385                 390                 395                 400 


Lys Val Gln Ile His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His 
                405                 410                 415     


Ser Asn Asp Leu Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val 
            420                 425                 430         


Asn Pro Arg Leu Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro 
        435                 440                 445             


Gly Leu Ala Pro Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg 
    450                 455                 460                 


Lys Lys Gln His Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp 
465                 470                 475                 480 


Gly Thr Ile Ile Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser 
                485                 490                 495     


Val Thr Leu Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys 
            500                 505                 510         


Glu Asp Leu Ala Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val 
        515                 520                 525             


Lys Ala Gly Ser Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala 
    530                 535                 540                 


Phe Phe Met Glu Tyr Val Lys Ser Trp Phe Trp Gly Pro Val Val Thr 
545                 550                 555                 560 


Leu Gln Asp Cys Leu Ala Ala Phe Phe Ala Arg Asp Glu Leu Lys Gly 
                565                 570                 575     


Asp Asn Met Tyr Ser Cys Glu Lys Cys Lys Lys Leu Arg Asn Gly Val 
            580                 585                 590         


Lys Phe Cys Lys Val Gln Asn Phe Pro Glu Ile Leu Cys Ile His Leu 
        595                 600                 605             


Lys Arg Phe Arg His Glu Leu Met Phe Ser Thr Lys Ile Ser Thr His 
    610                 615                 620                 


Val Ser Phe Pro Leu Glu Gly Leu Asp Leu Gln Pro Phe Leu Ala Lys 
625                 630                 635                 640 


Asp Ser Pro Ala Gln Ile Val Thr Tyr Asp Leu Leu Ser Val Ile Cys 
                645                 650                 655     


His His Gly Thr Ala Ser Ser Gly His Tyr Ile Ala Tyr Cys Arg Asn 
            660                 665                 670         


Asn Leu Asn Asn Leu Trp Tyr Glu Phe Asp Asp Gln Ser Val Thr Glu 
        675                 680                 685             


Val Ser Glu Ser Thr Val Gln Asn Ala Glu Ala Tyr Val Leu Phe Tyr 
    690                 695                 700                 


Arg Lys Ser Ser Glu Glu Ala Gln Lys Glu Arg Arg Arg Ile Ser Asn 
705                 710                 715                 720 


Leu Leu Asn Ile Met Glu Pro Ser Leu Leu Gln Phe Tyr Ile Ser Arg 
                725                 730                 735     


Gln Trp Leu Asn Lys Phe Lys Thr Phe Ala Glu Pro Gly Pro Ile Ser 
            740                 745                 750         


Asn Asn Asp Phe Leu Cys Ile His Gly Gly Val Pro Pro Arg Lys Ala 
        755                 760                 765             


Gly Tyr Ile Glu Asp Leu Val Leu Met Leu Pro Gln Asn Ile Trp Asp 
    770                 775                 780                 


Asn Leu Tyr Ser Arg Tyr Gly Gly Gly Pro Ala Val Asn His Leu Tyr 
785                 790                 795                 800 


Ile Cys His Thr Cys Gln Ile Glu Ala Glu Lys Ile Glu Lys Arg Arg 
                805                 810                 815     


Lys Thr Glu Leu Glu Ile Phe Ile Arg Val Lys Lys 
            820                 825             


<210> 6263
<211> 942
<212> PRT
<213> Homo sapiens

<400> 6263
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg Val 
            100                 105                 110         


Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu Gly 
        115                 120                 125             


Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln Glu 
    130                 135                 140                 


Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys Thr 
145                 150                 155                 160 


Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu Glu 
                165                 170                 175     


Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn 
            180                 185                 190         


Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro 
        195                 200                 205             


Leu Thr Gln Phe Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys 
    210                 215                 220                 


Lys Pro Ala Ile Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp 
225                 230                 235                 240 


His Lys Ser Arg Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly 
                245                 250                 255     


Ile Lys Thr Val Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala 
            260                 265                 270         


Gln Glu Phe Leu Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys 
        275                 280                 285             


Glu Gln Val Met Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu 
    290                 295                 300                 


Glu Thr Met Glu Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser 
305                 310                 315                 320 


Cys Glu Ser Cys Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser 
                325                 330                 335     


Arg Cys Phe Ser Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp 
            340                 345                 350         


Asp Glu Asn Asn Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met 
        355                 360                 365             


Cys Asn Lys Ile Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp 
    370                 375                 380                 


Arg Asp Ser Ile Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val 
385                 390                 395                 400 


Lys Val Gln Ile His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His 
                405                 410                 415     


Ser Asn Asp Leu Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val 
            420                 425                 430         


Asn Pro Arg Leu Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro 
        435                 440                 445             


Gly Leu Ala Pro Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg 
    450                 455                 460                 


Lys Lys Gln His Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp 
465                 470                 475                 480 


Gly Thr Ile Ile Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser 
                485                 490                 495     


Val Thr Leu Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys 
            500                 505                 510         


Glu Asp Leu Ala Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val 
        515                 520                 525             


Lys Ala Gly Ser Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala 
    530                 535                 540                 


Phe Phe Met Glu Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser 
545                 550                 555                 560 


Trp Phe Trp Gly Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe 
                565                 570                 575     


Phe Ala Arg Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys 
            580                 585                 590         


Cys Lys Lys Leu Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe 
        595                 600                 605             


Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met 
    610                 615                 620                 


Phe Ser Thr Lys Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu 
625                 630                 635                 640 


Asp Leu Gln Pro Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr 
                645                 650                 655     


Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly 
            660                 665                 670         


His Tyr Ile Ala Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu 
        675                 680                 685             


Phe Asp Asp Gln Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn 
    690                 695                 700                 


Ala Glu Ala Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala Gln 
705                 710                 715                 720 


Lys Glu Arg Arg Arg Ile Ser Asn Leu Leu Asn Ile Met Glu Pro Ser 
                725                 730                 735     


Leu Leu Gln Phe Tyr Ile Ser Arg Gln Trp Leu Asn Lys Phe Lys Thr 
            740                 745                 750         


Phe Ala Glu Pro Gly Pro Ile Ser Asn Asn Asp Phe Leu Cys Ile His 
        755                 760                 765             


Gly Gly Val Pro Pro Arg Lys Ala Gly Tyr Ile Glu Asp Leu Val Leu 
    770                 775                 780                 


Met Leu Pro Gln Asn Ile Trp Asp Asn Leu Tyr Ser Arg Tyr Gly Gly 
785                 790                 795                 800 


Gly Pro Ala Val Asn His Leu Tyr Ile Cys His Thr Cys Gln Ile Glu 
                805                 810                 815     


Ala Glu Lys Ile Glu Lys Arg Arg Lys Thr Glu Leu Glu Ile Phe Ile 
            820                 825                 830         


Arg Leu Asn Arg Ala Phe Gln Lys Glu Asp Ser Pro Ala Thr Phe Tyr 
        835                 840                 845             


Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ser Phe Val Lys Gly 
    850                 855                 860                 


Lys Asp Gly Asp Pro Pro Gly Pro Ile Asp Asn Thr Lys Ile Ala Val 
865                 870                 875                 880 


Thr Lys Cys Gly Asn Val Met Leu Arg Gln Gly Ala Asp Ser Gly Gln 
                885                 890                 895     


Ile Ser Glu Glu Thr Trp Asn Phe Leu Gln Ser Ile Tyr Gly Gly Gly 
            900                 905                 910         


Pro Glu Val Ile Leu Arg Pro Pro Val Val His Val Asp Pro Asp Ile 
        915                 920                 925             


Leu Gln Ala Glu Glu Lys Ile Glu Val Glu Thr Arg Ser Leu 
    930                 935                 940         


<210> 6264
<211> 911
<212> PRT
<213> Homo sapiens

<400> 6264
Met Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu 
1               5                   10                  15      


Ile Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp 
            20                  25                  30          


Cys Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys 
        35                  40                  45              


Ser Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His 
    50                  55                  60                  


Ser Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg 
65                  70                  75                  80  


Val Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu 
                85                  90                  95      


Gly Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln 
            100                 105                 110         


Glu Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys 
        115                 120                 125             


Thr Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu 
    130                 135                 140                 


Glu Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly 
145                 150                 155                 160 


Asn Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro 
                165                 170                 175     


Pro Leu Thr Gln Phe Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp 
            180                 185                 190         


Lys Lys Pro Ala Ile Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu 
        195                 200                 205             


Trp His Lys Ser Arg Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln 
    210                 215                 220                 


Gly Ile Lys Thr Val Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp 
225                 230                 235                 240 


Ala Gln Glu Phe Leu Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu 
                245                 250                 255     


Lys Glu Gln Val Met Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr 
            260                 265                 270         


Glu Glu Thr Met Glu Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln 
        275                 280                 285             


Ser Cys Glu Ser Cys Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly 
    290                 295                 300                 


Ser Arg Cys Phe Ser Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln 
305                 310                 315                 320 


Asp Asp Glu Asn Asn Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys 
                325                 330                 335     


Met Cys Asn Lys Ile Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys 
            340                 345                 350         


Asp Arg Asp Ser Ile Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr 
        355                 360                 365             


Val Lys Val Gln Ile His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val 
    370                 375                 380                 


His Ser Asn Asp Leu Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly 
385                 390                 395                 400 


Val Asn Pro Arg Leu Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp 
                405                 410                 415     


Pro Gly Leu Ala Pro Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys 
            420                 425                 430         


Arg Lys Lys Gln His Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe 
        435                 440                 445             


Asp Gly Thr Ile Ile Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val 
    450                 455                 460                 


Ser Val Thr Leu Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly 
465                 470                 475                 480 


Lys Glu Asp Leu Ala Lys Leu His Ser Ser Ser His Pro Thr Ser Ile 
                485                 490                 495     


Val Lys Ala Gly Ser Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile 
            500                 505                 510         


Ala Phe Phe Met Glu Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro 
        515                 520                 525             


Ser Trp Phe Trp Gly Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala 
    530                 535                 540                 


Phe Phe Ala Arg Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu 
545                 550                 555                 560 


Lys Cys Lys Lys Leu Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn 
                565                 570                 575     


Phe Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Leu 
            580                 585                 590         


Met Phe Ser Thr Lys Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly 
        595                 600                 605             


Leu Asp Leu Gln Pro Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val 
    610                 615                 620                 


Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Ser Ser 
625                 630                 635                 640 


Gly His Tyr Ile Ala Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr 
                645                 650                 655     


Glu Phe Asp Asp Gln Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln 
            660                 665                 670         


Asn Ala Glu Ala Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala 
        675                 680                 685             


Gln Lys Glu Arg Arg Arg Ile Ser Asn Leu Leu Asn Ile Met Glu Pro 
    690                 695                 700                 


Ser Leu Leu Gln Phe Tyr Ile Ser Arg Gln Trp Leu Asn Lys Phe Lys 
705                 710                 715                 720 


Thr Phe Ala Glu Pro Gly Pro Ile Ser Asn Asn Asp Phe Leu Cys Ile 
                725                 730                 735     


His Gly Gly Val Pro Pro Arg Lys Ala Gly Tyr Ile Glu Asp Leu Val 
            740                 745                 750         


Leu Met Leu Pro Gln Asn Ile Trp Asp Asn Leu Tyr Ser Arg Tyr Gly 
        755                 760                 765             


Gly Gly Pro Ala Val Asn His Leu Tyr Ile Cys His Thr Cys Gln Ile 
    770                 775                 780                 


Glu Ala Glu Lys Ile Glu Lys Arg Arg Lys Thr Glu Leu Glu Ile Phe 
785                 790                 795                 800 


Ile Arg Leu Asn Arg Ala Phe Gln Lys Glu Asp Ser Pro Ala Thr Phe 
                805                 810                 815     


Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ser Phe Val Lys 
            820                 825                 830         


Gly Lys Asp Gly Asp Pro Pro Gly Pro Ile Asp Asn Thr Lys Ile Ala 
        835                 840                 845             


Val Thr Lys Cys Gly Asn Val Met Leu Arg Gln Gly Ala Asp Ser Gly 
    850                 855                 860                 


Gln Ile Ser Glu Glu Thr Trp Asn Phe Leu Gln Ser Ile Tyr Gly Gly 
865                 870                 875                 880 


Gly Pro Glu Val Ile Leu Arg Pro Pro Val Val His Val Asp Pro Asp 
                885                 890                 895     


Ile Leu Gln Ala Glu Glu Lys Ile Glu Val Glu Thr Arg Ser Leu 
            900                 905                 910     


<210> 6265
<211> 154
<212> PRT
<213> Homo sapiens

<400> 6265
Met Ala Pro Pro Val Arg Tyr Cys Ile Pro Gly Glu Arg Leu Cys Asn 
1               5                   10                  15      


Leu Glu Glu Gly Ser Pro Gly Ser Gly Thr Tyr Thr Arg His Gly Tyr 
            20                  25                  30          


Ile Phe Ser Ser Leu Ala Gly Cys Leu Met Lys Ser Ser Glu Asn Gly 
        35                  40                  45              


Ala Leu Pro Val Val Ser Val Val Arg Glu Thr Glu Ser Gln Leu Leu 
    50                  55                  60                  


Pro Asp Val Gly Ala Ile Val Thr Cys Lys Val Glu Ile Tyr Lys Ser 
65                  70                  75                  80  


Phe Arg Pro Gly Asp Ile Val Leu Ala Lys Val Ile Ser Leu Gly Asp 
                85                  90                  95      


Ala Gln Ser Asn Tyr Leu Leu Thr Thr Ala Glu Asn Glu Leu Gly Val 
            100                 105                 110         


Val Val Ala His Ser Glu Ser Gly Ile Gln Met Val Pro Ile Ser Trp 
        115                 120                 125             


Cys Glu Met Gln Cys Pro Lys Thr His Thr Lys Glu Phe Arg Lys Val 
    130                 135                 140                 


Ala Arg Val Gln Pro Glu Phe Leu Gln Thr 
145                 150                 


<210> 6266
<211> 170
<212> PRT
<213> Homo sapiens

<400> 6266
Met Ala Pro Pro Val Arg Tyr Cys Ile Pro Gly Glu Arg Leu Cys Asn 
1               5                   10                  15      


Leu Glu Glu Gly Ser Pro Gly Ser Gly Thr Tyr Thr Arg His Gly Tyr 
            20                  25                  30          


Ile Phe Ser Ser Leu Ala Gly Cys Leu Met Lys Ser Ser Glu Asn Gly 
        35                  40                  45              


Ala Val Ser Ser Ile Asn Ser Arg Phe Ala Lys Val His Ile Leu Tyr 
    50                  55                  60                  


Val Gly Ser Met Pro Leu Lys Asn Ser Phe Arg Gly Thr Ile Arg Lys 
65                  70                  75                  80  


Glu Asp Val Arg Ala Thr Glu Lys Asp Lys Val Glu Ile Tyr Lys Ser 
                85                  90                  95      


Phe Arg Pro Gly Asp Ile Val Leu Ala Lys Val Ile Ser Leu Gly Asp 
            100                 105                 110         


Ala Gln Ser Asn Tyr Leu Leu Thr Thr Ala Glu Asn Glu Leu Gly Val 
        115                 120                 125             


Val Val Ala His Ser Glu Ser Gly Ile Gln Met Val Pro Ile Ser Trp 
    130                 135                 140                 


Cys Glu Met Gln Cys Pro Lys Thr His Thr Lys Glu Phe Arg Lys Val 
145                 150                 155                 160 


Ala Arg Val Gln Pro Glu Phe Leu Gln Thr 
                165                 170 


<210> 6267
<211> 178
<212> PRT
<213> Homo sapiens

<400> 6267
Met Ala Pro Pro Val Arg Tyr Cys Ile Pro Gly Glu Arg Leu Cys Asn 
1               5                   10                  15      


Leu Glu Glu Gly Ser Pro Gly Ser Gly Thr Tyr Thr Arg His Gly Tyr 
            20                  25                  30          


Ile Phe Ser Ser Leu Ala Gly Cys Leu Met Lys Ser Ser Glu Asn Gly 
        35                  40                  45              


Ala Leu Pro Val Val Ser Val Val Arg Glu Thr Glu Ser Gln Leu Leu 
    50                  55                  60                  


Pro Asp Val Gly Ala Ile Val Thr Cys Lys Val Ser Ser Ile Asn Ser 
65                  70                  75                  80  


Arg Phe Ala Lys Val His Ile Leu Tyr Val Gly Ser Met Pro Leu Lys 
                85                  90                  95      


Asn Ser Phe Arg Gly Thr Ile Arg Lys Glu Asp Val Arg Ala Thr Glu 
            100                 105                 110         


Lys Asp Lys Ile Ser Leu Gly Asp Ala Gln Ser Asn Tyr Leu Leu Thr 
        115                 120                 125             


Thr Ala Glu Asn Glu Leu Gly Val Val Val Ala His Ser Glu Ser Gly 
    130                 135                 140                 


Ile Gln Met Val Pro Ile Ser Trp Cys Glu Met Gln Cys Pro Lys Thr 
145                 150                 155                 160 


His Thr Lys Glu Phe Arg Lys Val Ala Arg Val Gln Pro Glu Phe Leu 
                165                 170                 175     


Gln Thr 
        


<210> 6268
<211> 936
<212> PRT
<213> Homo sapiens

<400> 6268
Met Ala Ala Ala Arg Asp Pro Pro Glu Val Ser Leu Arg Glu Ala Thr 
1               5                   10                  15      


Gln Arg Lys Leu Arg Arg Phe Ser Glu Leu Arg Gly Lys Leu Val Ala 
            20                  25                  30          


Arg Gly Glu Phe Trp Asp Ile Val Ala Ile Thr Ala Ala Asp Glu Lys 
        35                  40                  45              


Gln Glu Leu Ala Tyr Asn Gln Gln Leu Ser Glu Lys Leu Lys Arg Lys 
    50                  55                  60                  


Glu Leu Pro Leu Gly Val Gln Tyr His Val Phe Val Asp Pro Ala Gly 
65                  70                  75                  80  


Ala Lys Ile Gly Asn Gly Gly Ser Thr Leu Cys Ala Leu Gln Cys Leu 
                85                  90                  95      


Glu Lys Leu Tyr Gly Asp Lys Trp Asn Ser Phe Thr Ile Leu Leu Ile 
            100                 105                 110         


His Ser Asp Glu Trp Lys Lys Lys Val Ser Glu Ser Tyr Val Ile Thr 
        115                 120                 125             


Ile Glu Arg Leu Glu Asp Asp Leu Gln Ile Lys Glu Lys Glu Leu Thr 
    130                 135                 140                 


Glu Leu Arg Asn Ile Phe Gly Ser Asp Glu Ala Phe Ser Lys Val Asn 
145                 150                 155                 160 


Leu Asn Tyr Arg Thr Glu Asn Gly Leu Ser Leu Leu His Leu Cys Cys 
                165                 170                 175     


Ile Cys Gly Gly Lys Lys Ser His Ile Arg Thr Leu Met Leu Lys Gly 
            180                 185                 190         


Leu Arg Pro Ser Arg Leu Thr Arg Asn Gly Phe Thr Ala Leu His Leu 
        195                 200                 205             


Ala Val Tyr Lys Asp Asn Ala Glu Leu Ile Thr Ser Leu Leu His Ser 
    210                 215                 220                 


Gly Ala Asp Ile Gln Gln Val Gly Tyr Gly Gly Leu Thr Ala Leu His 
225                 230                 235                 240 


Ile Ala Thr Ile Ala Gly His Leu Glu Ala Ala Asp Val Leu Leu Gln 
                245                 250                 255     


His Gly Ala Asn Val Asn Ile Gln Asp Ala Val Phe Phe Thr Pro Leu 
            260                 265                 270         


His Ile Ala Ala Tyr Tyr Gly His Glu Gln Val Thr Arg Leu Leu Leu 
        275                 280                 285             


Lys Phe Gly Ala Asp Val Asn Val Ser Gly Glu Val Gly Asp Arg Pro 
    290                 295                 300                 


Leu His Leu Ala Ser Ala Lys Gly Phe Leu Asn Ile Ala Lys Leu Leu 
305                 310                 315                 320 


Met Glu Glu Gly Ser Lys Ala Asp Val Asn Ala Gln Asp Asn Glu Asp 
                325                 330                 335     


His Val Pro Leu His Phe Cys Ser Arg Phe Gly His His Asp Ile Val 
            340                 345                 350         


Lys Tyr Leu Leu Gln Ser Asp Leu Glu Val Gln Pro His Val Val Asn 
        355                 360                 365             


Ile Tyr Gly Asp Thr Pro Leu His Leu Ala Cys Tyr Asn Gly Lys Phe 
    370                 375                 380                 


Glu Val Ala Lys Glu Ile Ile Gln Ile Ser Gly Thr Glu Ser Leu Thr 
385                 390                 395                 400 


Lys Glu Asn Ile Phe Ser Glu Thr Ala Phe His Ser Ala Cys Thr Tyr 
                405                 410                 415     


Gly Lys Ser Ile Asp Leu Val Lys Phe Leu Leu Asp Gln Asn Val Ile 
            420                 425                 430         


Asn Ile Asn His Gln Gly Arg Asp Gly His Thr Gly Leu His Ser Ala 
        435                 440                 445             


Cys Tyr His Gly His Ile Arg Leu Val Gln Phe Leu Leu Asp Asn Gly 
    450                 455                 460                 


Ala Asp Met Asn Leu Val Ala Cys Asp Pro Ser Arg Ser Ser Gly Glu 
465                 470                 475                 480 


Lys Asp Glu Gln Thr Cys Leu Met Trp Ala Tyr Glu Lys Gly His Asp 
                485                 490                 495     


Ala Ile Val Thr Leu Leu Lys His Tyr Lys Arg Pro Gln Asp Glu Leu 
            500                 505                 510         


Pro Cys Asn Glu Tyr Ser Gln Pro Gly Gly Asp Gly Ser Tyr Val Ser 
        515                 520                 525             


Val Pro Ser Pro Leu Gly Lys Ile Lys Ser Met Thr Lys Glu Lys Ala 
    530                 535                 540                 


Asp Ile Leu Leu Leu Arg Ala Gly Leu Pro Ser His Phe His Leu Gln 
545                 550                 555                 560 


Leu Ser Glu Ile Glu Phe His Glu Ile Ile Gly Ser Gly Ser Phe Gly 
                565                 570                 575     


Lys Val Tyr Lys Gly Arg Cys Arg Asn Lys Ile Val Ala Ile Lys Arg 
            580                 585                 590         


Tyr Arg Ala Asn Thr Tyr Cys Ser Lys Ser Asp Val Asp Met Phe Cys 
        595                 600                 605             


Arg Glu Val Ser Ile Leu Cys Gln Leu Asn His Pro Cys Val Ile Gln 
    610                 615                 620                 


Phe Val Gly Ala Cys Leu Asn Asp Pro Ser Gln Phe Ala Ile Val Thr 
625                 630                 635                 640 


Gln Tyr Ile Ser Gly Gly Ser Leu Phe Ser Leu Leu His Glu Gln Lys 
                645                 650                 655     


Arg Ile Leu Asp Leu Gln Ser Lys Leu Ile Ile Ala Val Asp Val Ala 
            660                 665                 670         


Lys Gly Met Glu Tyr Leu His Asn Leu Thr Gln Pro Ile Ile His Arg 
        675                 680                 685             


Asp Leu Asn Ser His Asn Ile Leu Leu Tyr Glu Asp Gly His Ala Val 
    690                 695                 700                 


Val Ala Asp Phe Gly Glu Ser Arg Phe Leu Gln Ser Leu Asp Glu Asp 
705                 710                 715                 720 


Asn Met Thr Lys Gln Pro Gly Asn Leu Arg Trp Met Ala Pro Glu Val 
                725                 730                 735     


Phe Thr Gln Cys Thr Arg Tyr Thr Ile Lys Ala Asp Val Phe Ser Tyr 
            740                 745                 750         


Ala Leu Cys Leu Trp Glu Ile Leu Thr Gly Glu Ile Pro Phe Ala His 
        755                 760                 765             


Leu Lys Pro Ala Ala Ala Ala Ala Asp Met Ala Tyr His His Ile Arg 
    770                 775                 780                 


Pro Pro Ile Gly Tyr Ser Ile Pro Lys Pro Ile Ser Ser Leu Leu Ile 
785                 790                 795                 800 


Arg Gly Trp Asn Ala Cys Pro Glu Gly Arg Pro Glu Phe Ser Glu Val 
                805                 810                 815     


Val Met Lys Leu Glu Glu Cys Leu Cys Asn Ile Glu Leu Met Ser Pro 
            820                 825                 830         


Ala Ser Ser Asn Ser Ser Gly Ser Leu Ser Pro Ser Ser Ser Ser Asp 
        835                 840                 845             


Cys Leu Val Asn Arg Gly Gly Pro Gly Arg Ser His Val Ala Ala Leu 
    850                 855                 860                 


Arg Ser Arg Phe Glu Leu Glu Tyr Ala Leu Asn Ala Arg Ser Tyr Ala 
865                 870                 875                 880 


Ala Leu Ser Gln Ser Ala Gly Gln Tyr Ser Ser Gln Gly Leu Ser Leu 
                885                 890                 895     


Glu Glu Met Lys Arg Ser Leu Gln Tyr Thr Pro Ile Asp Lys Tyr Gly 
            900                 905                 910         


Tyr Val Ser Asp Pro Met Ser Ser Met His Phe His Ser Cys Arg Asn 
        915                 920                 925             


Ser Ser Ser Phe Glu Asp Ser Ser 
    930                 935     


<210> 6269
<211> 169
<212> PRT
<213> Homo sapiens

<400> 6269
Met Ala Ala Ala Arg Asp Pro Pro Glu Val Ser Leu Arg Glu Ala Thr 
1               5                   10                  15      


Gln Arg Lys Leu Arg Arg Phe Ser Glu Leu Arg Gly Lys Leu Val Ala 
            20                  25                  30          


Arg Gly Glu Phe Trp Asp Ile Val Ala Ile Thr Ala Ala Asp Glu Lys 
        35                  40                  45              


Gln Glu Leu Ala Tyr Asn Gln Gln Leu Ser Glu Lys Leu Lys Arg Lys 
    50                  55                  60                  


Glu Leu Pro Leu Gly Val Gln Tyr His Val Phe Val Asp Pro Ala Gly 
65                  70                  75                  80  


Ala Lys Ile Gly Asn Gly Gly Ser Thr Leu Cys Ala Leu Gln Cys Leu 
                85                  90                  95      


Glu Lys Leu Tyr Gly Asp Lys Trp Asn Ser Phe Thr Ile Leu Leu Ile 
            100                 105                 110         


His Ser Val Ser Phe Gln Ile Tyr Gln Asn Ala Leu Ala Lys His Pro 
        115                 120                 125             


Val Ser Phe Lys Ala Tyr Trp Ile Gln Asp Val Leu Trp His Leu Ala 
    130                 135                 140                 


Gln Leu Trp Ser Ile Pro Asp Trp Gly Leu Met Phe Gln Leu Gly Lys 
145                 150                 155                 160 


Thr Ala Leu Leu Val Val Leu Thr Ser 
                165                 


<210> 6270
<211> 594
<212> PRT
<213> Homo sapiens

<400> 6270
Met Ala Ala Ala Arg Asp Pro Pro Glu Val Ser Leu Arg Glu Ala Thr 
1               5                   10                  15      


Gln Arg Lys Leu Arg Arg Phe Ser Glu Leu Arg Gly Lys Leu Val Ala 
            20                  25                  30          


Arg Gly Glu Phe Trp Asp Ile Val Ala Ile Thr Ala Ala Asp Glu Lys 
        35                  40                  45              


Gln Glu Leu Ala Tyr Asn Gln Gln Leu Ser Glu Lys Leu Lys Arg Lys 
    50                  55                  60                  


Glu Leu Pro Leu Gly Val Gln Tyr His Val Phe Val Asp Pro Ala Gly 
65                  70                  75                  80  


Ala Lys Ile Gly Asn Gly Gly Ser Thr Leu Cys Ala Leu Gln Cys Leu 
                85                  90                  95      


Glu Lys Leu Tyr Gly Asp Lys Trp Asn Ser Phe Thr Ile Leu Leu Ile 
            100                 105                 110         


His Ser Gly Gly Tyr Ser Gln Arg Leu Pro Asn Ala Ser Ala Leu Gly 
        115                 120                 125             


Lys Ile Phe Thr Ala Leu Pro Leu Gly Asn Pro Ile Tyr Gln Met Leu 
    130                 135                 140                 


Glu Leu Lys Leu Ala Met Tyr Ile Asp Phe Pro Leu Asn Met Asn Pro 
145                 150                 155                 160 


Gly Ile Leu Val Thr Cys Ala Asp Asp Ile Glu Leu Tyr Ser Ile Gly 
                165                 170                 175     


Glu Phe Glu Phe Ile Arg Phe Asp Lys Pro Gly Phe Thr Ala Leu Ala 
            180                 185                 190         


His Pro Ser Ser Leu Thr Ile Gly Thr Thr His Gly Val Phe Val Leu 
        195                 200                 205             


Asp Pro Phe Asp Asp Leu Lys His Arg Asp Leu Glu Tyr Arg Ser Cys 
    210                 215                 220                 


His Arg Phe Leu His Lys Pro Ser Ile Glu Lys Met Tyr Gln Phe Asn 
225                 230                 235                 240 


Ala Val Cys Arg Pro Gly Asn Phe Cys Gln Gln Asp Phe Ala Gly Gly 
                245                 250                 255     


Asp Ile Ala Asp Leu Lys Leu Asp Ser Asp Tyr Val Tyr Thr Asp Ser 
            260                 265                 270         


Leu Phe Tyr Met Asp His Lys Ser Ala Lys Met Leu Leu Ala Phe Tyr 
        275                 280                 285             


Glu Lys Ile Gly Thr Leu Ser Cys Glu Ile Asp Ala Tyr Gly Asp Phe 
    290                 295                 300                 


Leu Gln Ala Leu Gly Pro Gly Ala Thr Val Glu Tyr Thr Arg Asn Thr 
305                 310                 315                 320 


Ser Asn Val Ile Lys Glu Glu Ser Glu Leu Val Glu Met Arg Gln Arg 
                325                 330                 335     


Ile Phe His Leu Leu Lys Gly Thr Ser Leu Asn Val Val Val Leu Asn 
            340                 345                 350         


Asn Ser Lys Phe Tyr His Ile Gly Thr Thr Glu Glu Tyr Leu Phe Tyr 
        355                 360                 365             


Phe Thr Ser Asp Asn Ser Leu Lys Ser Glu Leu Gly Leu Gln Ser Ile 
    370                 375                 380                 


Thr Phe Ser Ile Phe Pro Asp Ile Pro Glu Cys Ser Gly Lys Thr Ser 
385                 390                 395                 400 


Cys Ile Ile Gln Ser Ile Leu Asp Ser Arg Cys Ser Val Ala Pro Gly 
                405                 410                 415     


Ser Val Val Glu Tyr Ser Arg Leu Gly Pro Asp Val Ser Val Gly Glu 
            420                 425                 430         


Asn Cys Ile Ile Ser Gly Ser Tyr Ile Leu Thr Lys Ala Ala Leu Pro 
        435                 440                 445             


Ala His Ser Phe Val Cys Ser Leu Ser Leu Lys Met Asn Arg Cys Leu 
    450                 455                 460                 


Lys Tyr Ala Thr Met Ala Phe Gly Val Gln Asp Asn Leu Lys Lys Ser 
465                 470                 475                 480 


Val Lys Thr Leu Ser Asp Ile Lys Leu Leu Gln Phe Phe Gly Val Cys 
                485                 490                 495     


Phe Leu Ser Cys Leu Asp Val Trp Asn Leu Lys Val Thr Glu Glu Leu 
            500                 505                 510         


Phe Ser Gly Asn Lys Thr Cys Leu Ser Leu Trp Thr Ala Arg Ile Phe 
        515                 520                 525             


Pro Val Cys Ser Ser Leu Ser Asp Ser Val Ile Thr Ser Leu Lys Met 
    530                 535                 540                 


Leu Asn Ala Val Lys Asn Lys Ser Ala Phe Ser Leu Asn Ser Tyr Lys 
545                 550                 555                 560 


Leu Leu Ser Ile Glu Glu Met Leu Ile Tyr Lys Asp Val Glu Asp Met 
                565                 570                 575     


Ile Thr Tyr Arg Glu Gln Ile Phe Leu Glu Ile Ser Leu Lys Ser Ser 
            580                 585                 590         


Leu Met 
        


<210> 6271
<211> 195
<212> PRT
<213> Homo sapiens

<400> 6271
Met Ala Pro Pro Val Arg Tyr Cys Ile Pro Gly Glu Arg Leu Cys Asn 
1               5                   10                  15      


Leu Glu Glu Gly Ser Pro Gly Ser Gly Thr Tyr Thr Arg His Gly Tyr 
            20                  25                  30          


Ile Phe Ser Ser Leu Ala Gly Cys Leu Met Lys Ser Ser Glu Asn Gly 
        35                  40                  45              


Ala Leu Pro Val Val Ser Val Val Arg Glu Thr Glu Ser Gln Leu Leu 
    50                  55                  60                  


Pro Asp Val Gly Ala Ile Val Thr Cys Lys Val Ser Ser Ile Asn Ser 
65                  70                  75                  80  


Arg Phe Ala Lys Val His Ile Leu Tyr Val Gly Ser Met Pro Leu Lys 
                85                  90                  95      


Asn Ser Phe Arg Gly Thr Ile Arg Lys Glu Asp Val Arg Ala Thr Glu 
            100                 105                 110         


Lys Asp Lys Val Glu Ile Tyr Lys Ser Phe Arg Pro Gly Asp Ile Val 
        115                 120                 125             


Leu Ala Lys Val Ile Ser Leu Gly Asp Ala Gln Ser Asn Tyr Leu Leu 
    130                 135                 140                 


Thr Thr Ala Glu Asn Glu Leu Gly Val Val Val Ala His Ser Glu Ser 
145                 150                 155                 160 


Gly Ile Gln Met Val Pro Ile Ser Trp Cys Glu Met Gln Cys Pro Lys 
                165                 170                 175     


Thr His Thr Lys Glu Phe Arg Lys Val Ala Arg Val Gln Pro Glu Phe 
            180                 185                 190         


Leu Gln Thr 
        195 


<210> 6272
<211> 541
<212> PRT
<213> Homo sapiens

<400> 6272
Met Thr Gly Glu Lys Ile Arg Ser Leu Arg Arg Asp His Lys Pro Ser 
1               5                   10                  15      


Lys Glu Glu Gly Asp Leu Leu Glu Pro Gly Asp Glu Glu Ala Ala Ala 
            20                  25                  30          


Ala Leu Gly Gly Thr Phe Thr Arg Ser Arg Ile Gly Lys Gly Gly Lys 
        35                  40                  45              


Ala Cys His Lys Ile Phe Ser Asn His His His Arg Leu Gln Leu Lys 
    50                  55                  60                  


Ala Ala Pro Ala Ser Ser Asn Pro Pro Gly Ala Pro Ala Leu Pro Leu 
65                  70                  75                  80  


His Asn Ser Ser Val Thr Ala Asn Ser Gln Ser Pro Ala Leu Leu Ala 
                85                  90                  95      


Gly Thr Asn Pro Val Ala Val Val Ala Asp Gly Gly Ser Cys Pro Ala 
            100                 105                 110         


His Tyr Pro Val His Glu Cys Val Phe Lys Gly Asp Val Arg Arg Leu 
        115                 120                 125             


Ser Ser Leu Ile Arg Thr His Asn Ile Gly Gln Lys Asp Asn His Gly 
    130                 135                 140                 


Asn Thr Pro Leu His Leu Ala Val Met Leu Gly Asn Lys Glu Cys Ala 
145                 150                 155                 160 


His Leu Leu Leu Ala His Asn Ala Pro Val Lys Val Lys Asn Ala Gln 
                165                 170                 175     


Gly Trp Ser Pro Leu Ala Glu Ala Ile Ser Tyr Gly Asp Arg Gln Met 
            180                 185                 190         


Ile Thr Ala Leu Leu Arg Lys Leu Lys Gln Gln Ser Arg Glu Ser Val 
        195                 200                 205             


Glu Glu Lys Arg Pro Arg Leu Leu Lys Ala Leu Lys Glu Leu Gly Asp 
    210                 215                 220                 


Phe Tyr Leu Glu Leu His Trp Asp Phe Gln Ser Trp Val Pro Leu Leu 
225                 230                 235                 240 


Ser Arg Ile Leu Pro Ser Asp Ala Cys Lys Ile Tyr Lys Gln Gly Ile 
                245                 250                 255     


Asn Ile Arg Leu Asp Thr Thr Leu Ile Asp Phe Thr Asp Met Lys Cys 
            260                 265                 270         


Gln Arg Gly Asp Leu Ser Phe Ile Phe Asn Gly Asp Ala Ala Pro Ser 
        275                 280                 285             


Glu Ser Phe Val Val Leu Asp Asn Glu Gln Lys Val Tyr Gln Arg Ile 
    290                 295                 300                 


His His Glu Glu Ser Glu Met Glu Thr Glu Glu Glu Val Asp Ile Leu 
305                 310                 315                 320 


Met Ser Ser Asp Ile Tyr Ser Ala Thr Leu Ser Thr Lys Ser Ile Ser 
                325                 330                 335     


Phe Thr Arg Ala Gln Thr Gly Trp Leu Phe Arg Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Val Gly Asn Phe Leu Ala Asp Phe Tyr Leu Val Asn Gly Leu Val 
        355                 360                 365             


Leu Glu Ser Arg Lys Arg Arg Glu His Leu Ser Glu Glu Asp Ile Leu 
    370                 375                 380                 


Arg Asn Lys Ala Ile Met Glu Ser Leu Ser Lys Gly Gly Asn Ile Met 
385                 390                 395                 400 


Glu Gln Asn Phe Glu Pro Ile Arg Arg Gln Ser Leu Thr Pro Pro Pro 
                405                 410                 415     


Gln Asn Thr Ile Thr Trp Glu Glu Tyr Ile Ser Ala Glu Asn Gly Lys 
            420                 425                 430         


Ala Pro His Leu Gly Arg Glu Leu Val Cys Lys Glu Ser Lys Lys Thr 
        435                 440                 445             


Phe Lys Ala Thr Ile Ala Met Ser Gln Glu Phe Pro Leu Gly Ile Glu 
    450                 455                 460                 


Leu Leu Leu Asn Val Leu Glu Val Val Ala Pro Phe Lys His Phe Asn 
465                 470                 475                 480 


Lys Leu Arg Glu Phe Val Gln Met Lys Leu Pro Pro Gly Phe Pro Val 
                485                 490                 495     


Lys Leu Asp Ile Pro Val Phe Pro Thr Ile Thr Ala Thr Val Thr Phe 
            500                 505                 510         


Gln Glu Phe Arg Tyr Asp Glu Phe Asp Gly Ser Ile Phe Thr Ile Pro 
        515                 520                 525             


Asp Asp Tyr Lys Glu Asp Pro Ser Arg Phe Pro Asp Leu 
    530                 535                 540     


<210> 6273
<211> 279
<212> PRT
<213> Homo sapiens

<400> 6273
Met Pro Cys Arg Arg Glu Glu Glu Glu Glu Ala Gly Glu Glu Ala Glu 
1               5                   10                  15      


Gly Glu Glu Glu Glu Glu Asp Ser Phe Leu Leu Leu Gln Gln Ser Val 
            20                  25                  30          


Ala Leu Gly Ser Ser Gly Glu Val Asp Arg Leu Val Ala Gln Ile Gly 
        35                  40                  45              


Glu Thr Leu Gln Leu Asp Ala Ala Gln His Ser Pro Ala Ser Pro Cys 
    50                  55                  60                  


Gly Pro Pro Gly Ala Pro Leu Arg Ala Pro Gly Pro Leu Ala Ala Ala 
65                  70                  75                  80  


Val Pro Ala Asp Lys Ala Arg Ser Pro Ala Val Pro Leu Leu Leu Pro 
                85                  90                  95      


Pro Ala Leu Ala Glu Thr Val Gly Pro Ala Pro Pro Gly Val Leu Arg 
            100                 105                 110         


Cys Ala Leu Gly Asp Arg Gly Arg Val Arg Gly Arg Ala Ala Pro Tyr 
        115                 120                 125             


Cys Val Ala Glu Leu Ala Thr Gly Pro Ser Ala Leu Ser Pro Leu Pro 
    130                 135                 140                 


Pro Gln Ala Asp Leu Asp Gly Pro Pro Gly Ala Gly Lys Gln Gly Ile 
145                 150                 155                 160 


Pro Gln Pro Leu Ser Gly Pro Cys Arg Arg Gly Trp Leu Arg Gly Ala 
                165                 170                 175     


Ala Ala Ser Arg Arg Leu Gln Gln Arg Arg Gly Ser Gln Pro Glu Thr 
            180                 185                 190         


Arg Thr Gly Asp Asp Asp Pro His Arg Leu Leu Gln Gln Leu Val Leu 
        195                 200                 205             


Ser Gly Asn Leu Ile Lys Glu Ala Val Arg Arg Leu His Ser Arg Arg 
    210                 215                 220                 


Leu Gln Leu Arg Ala Lys Leu Pro Gln Arg Pro Leu Leu Gly Pro Leu 
225                 230                 235                 240 


Ser Ala Pro Val His Glu Pro Pro Ser Pro Arg Ser Pro Arg Ala Ala 
                245                 250                 255     


Cys Ser Asp Pro Gly Ala Ser Gly Arg Ala Gln Leu Arg Thr Gly Asp 
            260                 265                 270         


Gly Val Leu Val Pro Gly Ser 
        275                 


<210> 6274
<211> 402
<212> PRT
<213> Homo sapiens

<400> 6274
Met Pro Leu His Ser Ser Leu Gly Asn Lys Ser Glu Thr Leu Ser Gln 
1               5                   10                  15      


Lys Lys Asn Asn Asn Asn Lys Glu Lys Thr Lys Arg Asn Ser Arg Asn 
            20                  25                  30          


Pro Pro Arg Thr Ala Leu Lys Glu Gly Lys Met Glu Glu Leu Ser Gln 
        35                  40                  45              


Ala Leu Ala Ser Ser Phe Ser Val Ser Gln Asp Leu Asn Ser Thr Ala 
    50                  55                  60                  


Ala Pro His Pro Arg Leu Ser Gln Tyr Lys Ser Lys Tyr Ser Ser Leu 
65                  70                  75                  80  


Glu Gln Ser Glu Arg Arg Arg Arg Leu Leu Glu Leu Gln Lys Ser Lys 
                85                  90                  95      


Arg Leu Asp Tyr Val Asn His Ala Arg Arg Leu Ala Glu Asp Asp Trp 
            100                 105                 110         


Thr Gly Met Glu Ser Glu Glu Glu Asn Lys Lys Asp Asp Glu Glu Met 
        115                 120                 125             


Asp Ile Asp Thr Val Lys Lys Leu Pro Lys His Tyr Ala Asn Gln Leu 
    130                 135                 140                 


Met Leu Ser Glu Trp Leu Ile Asp Val Pro Ser Asp Leu Gly Gln Glu 
145                 150                 155                 160 


Trp Ile Val Val Val Cys Pro Val Gly Lys Arg Ala Leu Ile Val Ala 
                165                 170                 175     


Ser Arg Gly Ser Thr Ser Ala Tyr Thr Lys Ser Gly Tyr Cys Val Asn 
            180                 185                 190         


Arg Phe Ser Ser Leu Leu Pro Gly Gly Asn Arg Arg Asn Ser Thr Ala 
        195                 200                 205             


Lys Asp Tyr Thr Ile Leu Asp Cys Ile Tyr Asn Glu Val Asn Gln Thr 
    210                 215                 220                 


Tyr Tyr Val Leu Asp Val Met Cys Trp Arg Gly His Pro Phe Tyr Asp 
225                 230                 235                 240 


Cys Gln Thr Asp Phe Arg Phe Tyr Trp Met His Ser Lys Leu Pro Glu 
                245                 250                 255     


Glu Glu Gly Leu Gly Glu Lys Thr Lys Leu Asn Pro Phe Lys Phe Val 
            260                 265                 270         


Gly Leu Lys Asn Phe Pro Cys Thr Pro Glu Ser Leu Cys Asp Val Leu 
        275                 280                 285             


Ser Met Asp Phe Pro Phe Glu Val Asp Gly Leu Leu Phe Tyr His Lys 
    290                 295                 300                 


Gln Thr His Tyr Ser Pro Gly Ser Thr Pro Leu Val Gly Trp Leu Arg 
305                 310                 315                 320 


Pro Tyr Met Val Ser Asp Val Leu Gly Val Ala Val Pro Ala Gly Pro 
                325                 330                 335     


Leu Thr Thr Lys Pro Asp Tyr Ala Gly His Gln Leu Gln Gln Ile Met 
            340                 345                 350         


Glu His Lys Lys Ser Gln Lys Glu Gly Met Lys Glu Lys Leu Thr His 
        355                 360                 365             


Lys Ala Ser Glu Asn Gly His Tyr Glu Leu Glu His Leu Ser Thr Pro 
    370                 375                 380                 


Lys Leu Lys Gly Ser Ser His Ser Pro Asp His Pro Gly Cys Leu Met 
385                 390                 395                 400 


Glu Asn 
        


<210> 6275
<211> 368
<212> PRT
<213> Homo sapiens

<400> 6275
Met Ser Leu Phe Gly Thr Thr Ser Gly Phe Gly Thr Ser Gly Thr Ser 
1               5                   10                  15      


Met Phe Gly Ser Ala Thr Thr Asp Asn His Asn Pro Met Lys Asp Ile 
            20                  25                  30          


Glu Val Thr Ser Ser Pro Asp Asp Ser Ile Gly Cys Leu Ser Phe Ser 
        35                  40                  45              


Pro Pro Thr Leu Pro Gly Asn Phe Leu Ile Ala Gly Ser Trp Ala Asn 
    50                  55                  60                  


Asp Val Arg Cys Trp Glu Val Gln Asp Ser Gly Gln Thr Ile Pro Lys 
65                  70                  75                  80  


Ala Gln Gln Met His Thr Gly Pro Val Leu Asp Val Cys Trp Ser Asp 
                85                  90                  95      


Asp Gly Ser Lys Val Phe Thr Ala Ser Cys Asp Lys Thr Ala Lys Met 
            100                 105                 110         


Trp Asp Leu Ser Ser Asn Gln Ala Ile Gln Ile Ala Gln His Asp Ala 
        115                 120                 125             


Pro Val Lys Thr Ile His Trp Ile Lys Ala Pro Asn Tyr Ser Cys Val 
    130                 135                 140                 


Met Thr Gly Ser Trp Asp Lys Thr Leu Lys Phe Trp Asp Thr Arg Ser 
145                 150                 155                 160 


Ser Asn Pro Met Met Val Leu Gln Leu Pro Glu Arg Cys Tyr Cys Ala 
                165                 170                 175     


Asp Val Ile Tyr Pro Met Ala Val Val Ala Thr Ala Glu Arg Gly Leu 
            180                 185                 190         


Ile Val Tyr Gln Leu Glu Asn Gln Pro Ser Glu Phe Arg Arg Ile Glu 
        195                 200                 205             


Ser Pro Leu Lys His Gln His Arg Cys Val Ala Ile Phe Lys Asp Lys 
    210                 215                 220                 


Gln Asn Lys Pro Thr Gly Phe Ala Leu Gly Ser Ile Glu Gly Arg Val 
225                 230                 235                 240 


Ala Ile His Tyr Ile Asn Pro Pro Asn Pro Ala Lys Asp Asn Phe Thr 
                245                 250                 255     


Phe Lys Cys His Arg Ser Asn Gly Thr Asn Thr Ser Ala Pro Gln Asp 
            260                 265                 270         


Ile Tyr Ala Val Asn Gly Ile Ala Phe His Pro Val His Gly Thr Leu 
        275                 280                 285             


Ala Thr Val Gly Ser Asp Gly Arg Phe Ser Phe Trp Asp Lys Asp Ala 
    290                 295                 300                 


Arg Thr Lys Leu Lys Thr Ser Glu Gln Leu Asp Gln Pro Ile Ser Ala 
305                 310                 315                 320 


Cys Cys Phe Asn His Asn Gly Asn Ile Phe Ala Tyr Ala Ser Ser Tyr 
                325                 330                 335     


Asp Trp Ser Lys Gly His Glu Phe Tyr Asn Pro Gln Lys Lys Asn Tyr 
            340                 345                 350         


Ile Phe Leu Arg Asn Ala Ala Glu Glu Leu Lys Pro Arg Asn Lys Lys 
        355                 360                 365             


<210> 6276
<211> 183
<212> PRT
<213> Homo sapiens

<400> 6276
Met Arg Lys Ser Ser Cys Val Glu Ser Phe Asp Asp Gln Arg Arg Met 
1               5                   10                  15      


Ser Leu His Leu His Gly Ala Asp Cys Asp Pro Lys Thr Gln Asn Glu 
            20                  25                  30          


Met Asn Ile Cys Glu Glu Glu Phe Val Glu Tyr Lys Asn Arg Asp Ala 
        35                  40                  45              


Ile Ser Ala Leu Met Pro Leu Phe Ser Glu Glu Glu Ser Ser Asp Gly 
    50                  55                  60                  


Ser Lys His Asn Asn Gly Leu Pro Asp His Ile Ser Ala Gln Leu Gln 
65                  70                  75                  80  


Asn Thr Tyr Thr Leu Lys Ala Phe Thr Val Gly Ser Lys Cys Val Val 
                85                  90                  95      


Trp Ser Ser Leu Arg Asn Thr Trp Ser Lys Cys Glu Ile Leu Glu Thr 
            100                 105                 110         


Ala Glu Glu Gly Thr Arg Val Leu Asn Leu Ser Asn Gly Met Glu Glu 
        115                 120                 125             


Ile Val Asn Pro Glu Asn Val Trp Asn Gly Ile Pro Lys Leu Asp Lys 
    130                 135                 140                 


Ser Pro Pro Glu Ala Val Ser Gln Arg Val Gly Lys Asp Leu Tyr Phe 
145                 150                 155                 160 


Met Ser Val Gly Asp Thr Thr Ile Lys Glu Lys Gly Phe Gly Gly Asp 
                165                 170                 175     


Gly Asp Leu Thr Val Asp Leu 
            180             


<210> 6277
<211> 606
<212> PRT
<213> Homo sapiens

<400> 6277
Met Pro Ser Pro Gln Leu Leu Val Leu Phe Gly Ser Gln Thr Gly Thr 
1               5                   10                  15      


Ala Gln Asp Val Ser Glu Arg Leu Gly Arg Glu Ala Arg Arg Arg Arg 
            20                  25                  30          


Leu Gly Cys Arg Val Gln Ala Leu Asp Ser Tyr Pro Val Val Asn Leu 
        35                  40                  45              


Ile Asn Glu Pro Leu Val Ile Phe Val Cys Ala Thr Thr Gly Gln Gly 
    50                  55                  60                  


Asp Pro Pro Asp Asn Met Lys Asn Phe Trp Arg Phe Ile Phe Arg Lys 
65                  70                  75                  80  


Asn Leu Pro Ser Thr Ala Leu Cys Gln Met Asp Phe Ala Val Leu Gly 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Ala Lys Phe Asn Phe Val Ala Lys Lys Leu 
            100                 105                 110         


His Arg Arg Leu Leu Gln Leu Gly Gly Ser Ala Leu Leu Pro Val Cys 
        115                 120                 125             


Leu Gly Asp Asp Gln His Glu Leu Gly Pro Asp Ala Ala Val Asp Pro 
    130                 135                 140                 


Trp Leu Arg Asp Leu Trp Asp Arg Val Leu Gly Leu Tyr Pro Pro Pro 
145                 150                 155                 160 


Pro Gly Leu Thr Glu Ile Pro Pro Gly Val Pro Leu Pro Ser Lys Phe 
                165                 170                 175     


Thr Leu Leu Phe Leu Gln Glu Ala Pro Ser Thr Gly Ser Glu Gly Gln 
            180                 185                 190         


Arg Val Ala His Pro Gly Ser Gln Glu Pro Pro Ser Glu Ser Lys Pro 
        195                 200                 205             


Phe Leu Ala Pro Met Ile Ser Asn Gln Arg Val Thr Gly Pro Ser His 
    210                 215                 220                 


Phe Gln Asp Val Arg Leu Ile Glu Phe Asp Ile Leu Gly Ser Gly Ile 
225                 230                 235                 240 


Ser Phe Ala Ala Gly Asp Val Val Leu Ile Gln Pro Ser Asn Ser Ala 
                245                 250                 255     


Ala His Val Gln Arg Phe Cys Gln Val Leu Gly Leu Asp Pro Asp Gln 
            260                 265                 270         


Leu Phe Met Leu Gln Pro Arg Glu Pro Asp Val Ser Ser Pro Thr Arg 
        275                 280                 285             


Leu Pro Gln Pro Cys Ser Met Arg His Leu Val Ser His Tyr Leu Asp 
    290                 295                 300                 


Ile Ala Ser Val Pro Arg Arg Ser Phe Phe Glu Leu Leu Ala Cys Leu 
305                 310                 315                 320 


Ser Leu His Glu Leu Glu Arg Glu Lys Leu Leu Glu Phe Ser Ser Ala 
                325                 330                 335     


Gln Gly Gln Glu Glu Leu Phe Glu Tyr Cys Asn Arg Pro Arg Arg Thr 
            340                 345                 350         


Ile Leu Glu Val Leu Cys Asp Phe Pro His Thr Ala Ala Ala Ile Pro 
        355                 360                 365             


Pro Asp Tyr Leu Leu Asp Leu Ile Pro Val Ile Arg Pro Arg Ala Phe 
    370                 375                 380                 


Ser Ile Ala Ser Ser Leu Leu Thr His Pro Ser Arg Leu Gln Ile Leu 
385                 390                 395                 400 


Val Ala Val Val Gln Phe Gln Thr Arg Leu Lys Glu Pro Arg Arg Gly 
                405                 410                 415     


Leu Cys Ser Ser Trp Leu Ala Ser Leu Asp Pro Gly Gln Gly Pro Val 
            420                 425                 430         


Arg Val Pro Leu Trp Val Arg Pro Gly Ser Leu Ala Phe Pro Glu Thr 
        435                 440                 445             


Pro Asp Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro 
    450                 455                 460                 


Phe Arg Ala Ala Ile Gln Glu Arg Val Ala Gln Gly Gln Thr Gly Asn 
465                 470                 475                 480 


Phe Leu Phe Phe Gly Cys Arg Trp Arg Asp Gln Asp Phe Tyr Trp Glu 
                485                 490                 495     


Ala Glu Trp Gln Glu Leu Glu Lys Arg Asp Cys Leu Thr Leu Ile Pro 
            500                 505                 510         


Ala Phe Ser Arg Glu Gln Pro Pro Ala Leu Phe Ser Ala Leu Gln Glu 
        515                 520                 525             


Gln Lys Val Tyr Val Gln His Arg Leu Arg Glu Leu Gly Ser Leu Val 
    530                 535                 540                 


Trp Glu Leu Leu Asp Arg Gln Gly Ala Tyr Phe Tyr Leu Ala Gly Asn 
545                 550                 555                 560 


Ala Lys Ser Met Pro Ala Asp Val Ser Glu Ala Leu Met Ser Ile Phe 
                565                 570                 575     


Gln Glu Glu Gly Gly Leu Cys Ser Pro Asp Ala Ala Ala Tyr Leu Ala 
            580                 585                 590         


Arg Leu Gln Gln Thr Arg Arg Phe Gln Thr Glu Thr Trp Ala 
        595                 600                 605     


<210> 6278
<211> 139
<212> PRT
<213> Homo sapiens

<400> 6278
Met Ala Glu Ser Asp Trp Asp Thr Val Thr Val Leu Arg Lys Lys Gly 
1               5                   10                  15      


Pro Thr Ala Ala Gln Ala Lys Ser Lys Gln Ala Ile Leu Ala Ala Gln 
            20                  25                  30          


Arg Arg Gly Glu Asp Val Glu Thr Ser Lys Lys Trp Ala Ala Gly Gln 
        35                  40                  45              


Asn Lys Gln His Ser Ile Thr Lys Asn Thr Ala Lys Leu Asp Arg Glu 
    50                  55                  60                  


Thr Glu Glu Leu His His Asp Arg Val Thr Leu Glu Val Gly Lys Val 
65                  70                  75                  80  


Ile Gln Gln Gly Arg Gln Ser Lys Gly Leu Thr Gln Lys Asp Leu Ala 
                85                  90                  95      


Thr Lys Ile Asn Glu Lys Pro Gln Val Ile Ala Asp Tyr Glu Ser Gly 
            100                 105                 110         


Arg Ala Ile Pro Asn Asn Gln Val Leu Gly Lys Ile Glu Arg Ala Ile 
        115                 120                 125             


Gly Glu Cys Pro Ser Thr Leu Arg Arg Val Arg 
    130                 135                 


<210> 6279
<211> 141
<212> PRT
<213> Homo sapiens

<400> 6279
Met Ala Glu Ser Asp Trp Asp Thr Val Thr Val Leu Arg Lys Lys Gly 
1               5                   10                  15      


Pro Thr Ala Ala Gln Ala Lys Ser Lys Gln Ala Ile Leu Ala Ala Gln 
            20                  25                  30          


Arg Arg Gly Glu Asp Val Glu Thr Ser Lys Lys Trp Ala Ala Gly Gln 
        35                  40                  45              


Asn Lys Gln His Ser Ile Thr Lys Asn Thr Ala Lys Leu Asp Arg Glu 
    50                  55                  60                  


Thr Glu Glu Leu His His Asp Arg Val Thr Leu Glu Val Gly Lys Val 
65                  70                  75                  80  


Ile Gln Gln Gly Arg Gln Ser Lys Gly Leu Thr Gln Lys Asp Leu Ala 
                85                  90                  95      


Thr Lys Ile Asn Glu Lys Pro Gln Val Ile Ala Asp Tyr Glu Ser Gly 
            100                 105                 110         


Arg Ala Ile Pro Asn Asn Gln Val Leu Gly Lys Ile Glu Arg Ala Ile 
        115                 120                 125             


Asp Val Gly Thr Arg Ser Ala Arg Val Leu Arg Ala Gln 
    130                 135                 140     


<210> 6280
<211> 49
<212> PRT
<213> Homo sapiens

<400> 6280
Met Ala Thr Gln Arg Lys His Leu Val Lys Asp Phe Asn Pro Tyr Ile 
1               5                   10                  15      


Thr Cys Tyr Ile Cys Lys Gly Tyr Leu Ile Lys Pro Thr Thr Val Thr 
            20                  25                  30          


Glu Cys Leu His Thr Ser Ala Glu Ser Tyr Trp Met Ser Thr Trp Met 
        35                  40                  45              


Ser 
    


<210> 6281
<211> 319
<212> PRT
<213> Homo sapiens

<400> 6281
Met Met Val Leu Lys Val Glu Glu Leu Val Thr Gly Lys Lys Asn Gly 
1               5                   10                  15      


Asn Gly Glu Ala Gly Glu Phe Leu Pro Glu Asp Phe Arg Asp Gly Glu 
            20                  25                  30          


Tyr Glu Ala Ala Val Thr Leu Glu Lys Gln Glu Asp Leu Lys Thr Leu 
        35                  40                  45              


Leu Ala His Pro Val Thr Leu Gly Glu Gln Gln Trp Lys Ser Glu Lys 
    50                  55                  60                  


Gln Arg Glu Ala Glu Leu Lys Lys Lys Lys Leu Glu Gln Arg Ser Lys 
65                  70                  75                  80  


Leu Glu Asn Leu Glu Asp Leu Glu Ile Ile Ile Gln Leu Lys Lys Arg 
                85                  90                  95      


Lys Lys Tyr Arg Lys Thr Lys Val Pro Val Val Lys Glu Pro Glu Pro 
            100                 105                 110         


Glu Ile Ile Thr Glu Pro Val Asp Val Pro Thr Phe Leu Lys Ala Ala 
        115                 120                 125             


Leu Glu Asn Lys Leu Pro Val Val Glu Lys Phe Leu Ser Asp Lys Asn 
    130                 135                 140                 


Asn Pro Asp Val Cys Asp Glu Tyr Lys Arg Thr Ala Leu His Arg Ala 
145                 150                 155                 160 


Cys Leu Glu Gly His Leu Ala Ile Val Glu Lys Leu Met Glu Ala Gly 
                165                 170                 175     


Ala Gln Ile Glu Phe Arg Asp Met Leu Glu Ser Thr Ala Ile His Trp 
            180                 185                 190         


Ala Ser Arg Gly Gly Asn Leu Asp Val Leu Lys Leu Leu Leu Asn Lys 
        195                 200                 205             


Gly Ala Lys Ile Ser Ala Arg Asp Lys Leu Leu Ser Thr Ala Leu His 
    210                 215                 220                 


Val Ala Val Arg Thr Gly His Tyr Glu Cys Ala Glu His Leu Ile Ala 
225                 230                 235                 240 


Cys Glu Ala Asp Leu Asn Ala Lys Asp Arg Glu Gly Asp Thr Pro Leu 
                245                 250                 255     


His Asp Ala Val Arg Leu Asn Arg Tyr Lys Met Ile Arg Leu Leu Ile 
            260                 265                 270         


Met Tyr Gly Ala Asp Leu Asn Ile Lys Asn Cys Ala Gly Lys Thr Pro 
        275                 280                 285             


Met Asp Leu Val Leu His Trp Gln Asn Gly Thr Lys Ala Ile Phe Asp 
    290                 295                 300                 


Ser Leu Arg Glu Asn Ser Tyr Lys Thr Ser Arg Ile Ala Thr Phe 
305                 310                 315                 


<210> 6282
<211> 362
<212> PRT
<213> Homo sapiens

<400> 6282
Met Ser Gly Tyr Gln Arg Arg Pro Gly Ala Thr Pro Leu Ser Arg Ala 
1               5                   10                  15      


Arg Ser Leu Ala Ile Pro Asp Asp Asp Arg Phe Glu Asp Leu Glu Glu 
            20                  25                  30          


Ala Asn Pro Phe Ser Phe Arg Glu Phe Leu Lys Thr Lys Asn Leu Gly 
        35                  40                  45              


Leu Ser Lys Glu Asp Pro Ala Ser Arg Ile Tyr Ala Lys Glu Ala Ser 
    50                  55                  60                  


Arg His Ser Leu Gly Leu Asp His Asn Ser Pro Pro Ser Gln Thr Gly 
65                  70                  75                  80  


Gly Tyr Gly Leu Glu Tyr Gln Gln Pro Phe Phe Glu Asp Pro Thr Gly 
                85                  90                  95      


Ala Gly Asp Leu Leu Asp Glu Glu Glu Asp Glu Asp Thr Gly Trp Ser 
            100                 105                 110         


Gly Ala Tyr Leu Pro Ser Ala Ile Glu Gln Thr His Pro Glu Arg Val 
        115                 120                 125             


Pro Ala Gly Thr Ser Pro Cys Ser Thr Tyr Leu Ser Phe Phe Ser Thr 
    130                 135                 140                 


Pro Ser Glu Leu Ala Gly Pro Glu Ser Leu Pro Ser Trp Ala Leu Ser 
145                 150                 155                 160 


Asp Thr Asp Ser Arg Val Ser Pro Ala Ser Pro Ala Gly Ser Pro Ser 
                165                 170                 175     


Ala Asp Phe Ala Val His Gly Glu Ser Leu Gly Asp Arg His Leu Arg 
            180                 185                 190         


Thr Leu Gln Ile Ser Tyr Asp Ala Leu Lys Asp Glu Asn Ser Lys Leu 
        195                 200                 205             


Arg Arg Lys Leu Asn Glu Val Gln Ser Phe Ser Glu Ala Gln Thr Glu 
    210                 215                 220                 


Met Val Arg Thr Leu Glu Arg Lys Leu Glu Ala Lys Met Ile Lys Glu 
225                 230                 235                 240 


Glu Ser Asp Tyr His Asp Leu Glu Ser Val Val Gln Gln Val Glu Gln 
                245                 250                 255     


Asn Leu Glu Leu Met Thr Lys Arg Ala Val Lys Ala Glu Asn His Val 
            260                 265                 270         


Val Lys Leu Lys Gln Glu Ile Ser Leu Leu Gln Ala Gln Val Ser Asn 
        275                 280                 285             


Phe Gln Arg Glu Asn Glu Ala Leu Arg Cys Gly Gln Gly Ala Ser Leu 
    290                 295                 300                 


Thr Val Val Lys Gln Asn Ala Asp Val Ala Leu Gln Asn Leu Arg Val 
305                 310                 315                 320 


Val Met Asn Ser Ala Gln Ala Ser Ile Lys Gln Leu Val Ser Gly Ala 
                325                 330                 335     


Glu Thr Leu Asn Leu Val Ala Glu Ile Leu Lys Ser Ile Asp Arg Ile 
            340                 345                 350         


Ser Glu Val Lys Asp Glu Glu Glu Asp Ser 
        355                 360         


<210> 6283
<211> 1820
<212> PRT
<213> Homo sapiens

<400> 6283
Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      


Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          


Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              


Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  


Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  


Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      


Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         


Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             


Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 


Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 


Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     


Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         


Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        195                 200                 205             


Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    210                 215                 220                 


Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                245                 250                 255     


Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            260                 265                 270         


Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        275                 280                 285             


Pro Val Ser Ser Lys Phe Gln Lys Arg Lys Met Leu Arg Leu Ser Gln 
    290                 295                 300                 


Asp Val Lys Gly Tyr Ser Phe Ile Lys Asp Leu Gln Trp Ile Gln Val 
305                 310                 315                 320 


Ser Asp Ser Lys Glu Ala Tyr Arg Leu Leu Lys Leu Gly Ile Lys His 
                325                 330                 335     


Gln Ser Val Ala Phe Thr Lys Leu Asn Asn Ala Ser Ser Arg Ser His 
            340                 345                 350         


Ser Ile Phe Thr Val Lys Ile Leu Gln Ile Glu Asp Ser Glu Met Ser 
        355                 360                 365             


Arg Val Ile Arg Val Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser 
    370                 375                 380                 


Glu Arg Thr Met Lys Thr Gln Asn Glu Gly Glu Arg Leu Arg Glu Thr 
385                 390                 395                 400 


Gly Asn Ile Asn Thr Ser Leu Leu Thr Leu Gly Lys Cys Ile Asn Val 
                405                 410                 415     


Leu Lys Asn Ser Glu Lys Ser Lys Phe Gln Gln His Val Pro Phe Arg 
            420                 425                 430         


Glu Ser Lys Leu Thr His Tyr Phe Gln Ser Phe Phe Asn Gly Lys Gly 
        435                 440                 445             


Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala Tyr Asp 
    450                 455                 460                 


Glu Thr Leu Asn Val Leu Lys Phe Ser Ala Ile Ala Gln Lys Val Cys 
465                 470                 475                 480 


Val Pro Asp Thr Leu Asn Ser Ser Gln Glu Lys Leu Phe Gly Pro Val 
                485                 490                 495     


Lys Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys Ile 
            500                 505                 510         


Leu Asn Val Lys Arg Ala Thr Ile Ser Trp Glu Asn Ser Leu Glu Asp 
        515                 520                 525             


Leu Met Glu Asp Glu Asp Leu Val Glu Glu Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


Thr Gln Asn Val Glu Thr Lys Leu Leu Asp Glu Asp Leu Asp Lys Thr 
545                 550                 555                 560 


Leu Glu Glu Asn Lys Ala Phe Ile Ser His Glu Glu Lys Arg Lys Leu 
                565                 570                 575     


Leu Asp Leu Ile Glu Asp Leu Lys Lys Lys Leu Ile Asn Glu Lys Lys 
            580                 585                 590         


Glu Lys Leu Thr Leu Glu Phe Lys Ile Arg Glu Glu Val Thr Gln Glu 
        595                 600                 605             


Phe Thr Gln Tyr Trp Ala Gln Arg Glu Ala Asp Phe Lys Glu Thr Leu 
    610                 615                 620                 


Leu Gln Glu Arg Glu Ile Leu Glu Glu Asn Ala Glu Arg Arg Leu Ala 
625                 630                 635                 640 


Ile Phe Lys Asp Leu Val Gly Lys Cys Asp Thr Arg Glu Glu Ala Ala 
                645                 650                 655     


Lys Asp Ile Cys Ala Thr Lys Val Glu Thr Glu Glu Thr His Asn Tyr 
            660                 665                 670         


Val Gly Phe Glu Asp Ile Ile Asp Ser Leu Gln Asp Asn Val Ala Asp 
        675                 680                 685             


Ile Lys Lys Gln Ala Glu Ile Ala His Leu Tyr Ile Ala Ser Leu Pro 
    690                 695                 700                 


Asp Pro Gln Glu Ala Thr Ala Cys Leu Glu Leu Lys Phe Asn Gln Ile 
705                 710                 715                 720 


Lys Ala Glu Leu Ala Lys Thr Lys Gly Glu Leu Ile Lys Thr Lys Glu 
                725                 730                 735     


Glu Leu Lys Lys Arg Glu Asn Glu Ser Asp Ser Leu Ile Gln Glu Leu 
            740                 745                 750         


Glu Thr Ser Asn Lys Lys Ile Ile Thr Gln Asn Gln Arg Ile Lys Glu 
        755                 760                 765             


Leu Ile Asn Ile Ile Asp Gln Lys Glu Asp Thr Ile Asn Glu Phe Gln 
    770                 775                 780                 


Asn Leu Lys Ser His Met Glu Asn Thr Phe Lys Cys Asn Asp Lys Ala 
785                 790                 795                 800 


Asp Thr Ser Ser Leu Ile Ile Asn Asn Lys Leu Ile Cys Asn Glu Thr 
                805                 810                 815     


Val Glu Val Pro Lys Asp Ser Lys Ser Lys Ile Cys Ser Glu Arg Lys 
            820                 825                 830         


Arg Val Asn Glu Asn Glu Leu Gln Gln Asp Glu Pro Pro Ala Lys Lys 
        835                 840                 845             


Gly Ser Ile His Val Ser Ser Ala Ile Thr Glu Asp Gln Lys Lys Ser 
    850                 855                 860                 


Glu Glu Val Arg Pro Asn Ile Ala Glu Ile Glu Asp Ile Arg Val Leu 
865                 870                 875                 880 


Gln Glu Asn Asn Glu Gly Leu Arg Ala Phe Leu Leu Thr Ile Glu Asn 
                885                 890                 895     


Glu Leu Lys Asn Glu Lys Glu Glu Lys Ala Glu Leu Asn Lys Gln Ile 
            900                 905                 910         


Val His Phe Gln Gln Glu Leu Ser Leu Ser Glu Lys Lys Asn Leu Thr 
        915                 920                 925             


Leu Ser Lys Glu Val Gln Gln Ile Gln Ser Asn Tyr Asp Ile Ala Ile 
    930                 935                 940                 


Ala Glu Leu His Val Gln Lys Ser Lys Asn Gln Glu Gln Glu Glu Lys 
945                 950                 955                 960 


Ile Met Lys Leu Ser Asn Glu Ile Glu Thr Ala Thr Arg Ser Ile Thr 
                965                 970                 975     


Asn Asn Val Ser Gln Ile Lys Leu Met His Thr Lys Ile Asp Glu Leu 
            980                 985                 990         


Arg Thr Leu Asp Ser Val Ser Gln  Ile Ser Asn Ile Asp  Leu Leu Asn 
        995                 1000                 1005             


Leu Arg  Asp Leu Ser Asn Gly  Ser Glu Glu Asp Asn  Leu Pro Asn 
    1010                 1015                 1020             


Thr Gln  Leu Asp Leu Leu Gly  Asn Asp Tyr Leu Val  Ser Lys Gln 
    1025                 1030                 1035             


Val Lys  Glu Tyr Arg Ile Gln  Glu Pro Asn Arg Glu  Asn Ser Phe 
    1040                 1045                 1050             


His Ser  Ser Ile Glu Ala Ile  Trp Glu Glu Cys Lys  Glu Ile Val 
    1055                 1060                 1065             


Lys Ala  Ser Ser Lys Lys Ser  His Gln Ile Glu Glu  Leu Glu Gln 
    1070                 1075                 1080             


Gln Ile  Glu Lys Leu Gln Ala  Glu Val Lys Gly Tyr  Lys Asp Glu 
    1085                 1090                 1095             


Asn Asn  Arg Leu Lys Glu Lys  Glu His Lys Asn Gln  Asp Asp Leu 
    1100                 1105                 1110             


Leu Lys  Glu Lys Glu Thr Leu  Ile Gln Gln Leu Lys  Glu Glu Leu 
    1115                 1120                 1125             


Gln Glu  Lys Asn Val Thr Leu  Asp Val Gln Ile Gln  His Val Val 
    1130                 1135                 1140             


Glu Gly  Lys Arg Ala Leu Ser  Glu Leu Thr Gln Gly  Val Thr Cys 
    1145                 1150                 1155             


Tyr Lys  Ala Lys Ile Lys Glu  Leu Glu Thr Ile Leu  Glu Thr Gln 
    1160                 1165                 1170             


Lys Val  Glu Cys Ser His Ser  Ala Lys Leu Glu Gln  Asp Ile Leu 
    1175                 1180                 1185             


Glu Lys  Glu Ser Ile Ile Leu  Lys Leu Glu Arg Asn  Leu Lys Glu 
    1190                 1195                 1200             


Phe Gln  Glu His Leu Gln Asp  Ser Val Lys Asn Thr  Lys Asp Leu 
    1205                 1210                 1215             


Asn Val  Lys Glu Leu Lys Leu  Lys Glu Glu Ile Thr  Gln Leu Thr 
    1220                 1225                 1230             


Asn Asn  Leu Gln Asp Met Lys  His Leu Leu Gln Leu  Lys Glu Glu 
    1235                 1240                 1245             


Glu Glu  Glu Thr Asn Arg Gln  Glu Thr Glu Lys Leu  Lys Glu Glu 
    1250                 1255                 1260             


Leu Ser  Ala Ser Ser Ala Arg  Thr Gln Asn Leu Lys  Ala Asp Leu 
    1265                 1270                 1275             


Gln Arg  Lys Glu Glu Asp Tyr  Ala Asp Leu Lys Glu  Lys Leu Thr 
    1280                 1285                 1290             


Asp Ala  Lys Lys Gln Ile Lys  Gln Val Gln Lys Glu  Val Ser Val 
    1295                 1300                 1305             


Met Arg  Asp Glu Asp Lys Leu  Leu Arg Ile Lys Ile  Asn Glu Leu 
    1310                 1315                 1320             


Glu Lys  Lys Lys Asn Gln Cys  Ser Gln Glu Leu Asp  Met Lys Gln 
    1325                 1330                 1335             


Arg Thr  Ile Gln Gln Leu Lys  Glu Gln Leu Asn Asn  Gln Lys Val 
    1340                 1345                 1350             


Glu Glu  Ala Ile Gln Gln Tyr  Glu Arg Ala Cys Lys  Asp Leu Asn 
    1355                 1360                 1365             


Val Lys  Glu Lys Ile Ile Glu  Asp Met Arg Met Thr  Leu Glu Glu 
    1370                 1375                 1380             


Gln Glu  Gln Thr Gln Val Glu  Gln Asp Gln Val Leu  Glu Ala Lys 
    1385                 1390                 1395             


Leu Glu  Glu Val Glu Arg Leu  Ala Thr Glu Leu Glu  Lys Trp Lys 
    1400                 1405                 1410             


Glu Lys  Cys Asn Asp Leu Glu  Thr Lys Asn Asn Gln  Arg Ser Asn 
    1415                 1420                 1425             


Lys Glu  His Glu Asn Asn Thr  Asp Val Leu Gly Lys  Leu Thr Asn 
    1430                 1435                 1440             


Leu Gln  Asp Glu Leu Gln Glu  Ser Glu Gln Lys Tyr  Asn Ala Asp 
    1445                 1450                 1455             


Arg Lys  Lys Trp Leu Glu Glu  Lys Met Met Leu Ile  Thr Gln Ala 
    1460                 1465                 1470             


Lys Glu  Ala Glu Asn Ile Arg  Asn Lys Glu Met Lys  Lys Tyr Ala 
    1475                 1480                 1485             


Glu Asp  Arg Glu Arg Phe Phe  Lys Gln Gln Asn Glu  Met Glu Ile 
    1490                 1495                 1500             


Leu Thr  Ala Gln Leu Thr Glu  Lys Asp Ser Asp Leu  Gln Lys Trp 
    1505                 1510                 1515             


Arg Glu  Glu Arg Asp Gln Leu  Val Ala Ala Leu Glu  Ile Gln Leu 
    1520                 1525                 1530             


Lys Ala  Leu Ile Ser Ser Asn  Val Gln Lys Asp Asn  Glu Ile Glu 
    1535                 1540                 1545             


Gln Leu  Lys Arg Ile Ile Ser  Glu Thr Ser Lys Ile  Glu Thr Gln 
    1550                 1555                 1560             


Ile Met  Asp Ile Lys Pro Lys  Arg Ile Ser Ser Ala  Asp Pro Asp 
    1565                 1570                 1575             


Lys Leu  Gln Thr Glu Pro Leu  Ser Thr Ser Phe Glu  Ile Ser Arg 
    1580                 1585                 1590             


Asn Lys  Ile Glu Asp Gly Ser  Val Val Leu Asp Ser  Cys Glu Val 
    1595                 1600                 1605             


Ser Thr  Glu Asn Asp Gln Ser  Thr Arg Phe Pro Lys  Pro Glu Leu 
    1610                 1615                 1620             


Glu Ile  Gln Phe Thr Pro Leu  Gln Pro Asn Lys Met  Ala Val Lys 
    1625                 1630                 1635             


His Pro  Gly Cys Thr Thr Pro  Val Thr Val Lys Ile  Pro Lys Ala 
    1640                 1645                 1650             


Arg Lys  Arg Lys Ser Asn Glu  Met Glu Glu Asp Leu  Val Lys Cys 
    1655                 1660                 1665             


Glu Asn  Lys Lys Asn Ala Thr  Pro Arg Thr Asn Leu  Lys Phe Pro 
    1670                 1675                 1680             


Ile Ser  Asp Asp Arg Asn Ser  Ser Val Lys Lys Glu  Gln Lys Val 
    1685                 1690                 1695             


Ala Ile  Arg Pro Ser Ser Lys  Lys Thr Tyr Ser Leu  Arg Ser Gln 
    1700                 1705                 1710             


Ala Ser  Ile Ile Gly Val Asn  Leu Ala Thr Lys Lys  Lys Glu Gly 
    1715                 1720                 1725             


Thr Leu  Gln Lys Phe Gly Asp  Phe Leu Gln His Ser  Pro Ser Ile 
    1730                 1735                 1740             


Leu Gln  Ser Lys Ala Lys Lys  Ile Ile Glu Thr Met  Ser Ser Ser 
    1745                 1750                 1755             


Lys Leu  Ser Asn Val Glu Ala  Ser Lys Glu Asn Val  Ser Gln Pro 
    1760                 1765                 1770             


Lys Arg  Ala Lys Arg Lys Leu  Tyr Thr Ser Glu Ile  Ser Ser Pro 
    1775                 1780                 1785             


Ile Asp  Ile Ser Gly Gln Val  Ile Leu Met Asp Gln  Lys Met Lys 
    1790                 1795                 1800             


Glu Ser  Asp His Gln Ile Ile  Lys Arg Arg Leu Arg  Thr Lys Thr 
    1805                 1810                 1815             


Ala Lys  
    1820 


<210> 6284
<211> 494
<212> PRT
<213> Homo sapiens

<400> 6284
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser Gly 
        115                 120                 125             


Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu Phe 
    130                 135                 140                 


Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn Ala 
145                 150                 155                 160 


Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro Ala 
                165                 170                 175     


Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile Val 
            180                 185                 190         


Lys Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile Ser Arg Leu 
        195                 200                 205             


Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu Tyr Thr Leu 
    210                 215                 220                 


Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val Met Gln Val 
225                 230                 235                 240 


Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn Lys Lys Val 
                245                 250                 255     


Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu Gly Phe Lys 
            260                 265                 270         


Val Pro Gln Ala Gln Pro Thr Lys Pro Ala Leu Lys Ser Glu Glu Lys 
        275                 280                 285             


Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr Phe Phe Glu 
    290                 295                 300                 


Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu Asp Glu Phe 
305                 310                 315                 320 


Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly Ile Leu Pro 
                325                 330                 335     


Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln Gly His His 
            340                 345                 350         


Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys Ala Thr Val 
        355                 360                 365             


Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr Ser Pro Thr 
    370                 375                 380                 


Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His Val Pro His 
385                 390                 395                 400 


Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu Ser Arg Val 
                405                 410                 415     


Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn Asn Lys Asn 
            420                 425                 430         


Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro Leu Ile Ser 
        435                 440                 445             


His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met Ala Ala Leu 
    450                 455                 460                 


Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser Thr Glu Met 
465                 470                 475                 480 


Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg Cys 
                485                 490                 


<210> 6285
<211> 502
<212> PRT
<213> Homo sapiens

<400> 6285
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Ser Phe Pro Leu Lys Gln 
        115                 120                 125             


Val Ala Arg Glu Ser Gly Pro Pro His Met Lys Asn Phe Val Thr Lys 
    130                 135                 140                 


Val Ser Val Gly Glu Phe Val Gly Glu Gly Glu Gly Lys Ser Lys Lys 
145                 150                 155                 160 


Ile Ser Lys Lys Asn Ala Ala Ile Ala Val Leu Glu Glu Leu Lys Lys 
                165                 170                 175     


Leu Pro Pro Leu Pro Ala Val Glu Arg Val Lys Pro Arg Ile Lys Lys 
            180                 185                 190         


Lys Thr Lys Pro Ile Val Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln 
        195                 200                 205             


Gly Ile Asn Pro Ile Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys 
    210                 215                 220                 


Glu Lys Glu Pro Glu Tyr Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg 
225                 230                 235                 240 


Arg Arg Glu Phe Val Met Gln Val Lys Val Gly Asn His Thr Ala Glu 
                245                 250                 255     


Gly Thr Gly Thr Asn Lys Lys Val Ala Lys Arg Asn Ala Ala Glu Asn 
            260                 265                 270         


Met Leu Glu Ile Leu Gly Phe Lys Val Pro Gln Ala Gln Pro Thr Lys 
        275                 280                 285             


Pro Ala Leu Lys Ser Glu Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp 
    290                 295                 300                 


Gly Arg Lys Val Thr Phe Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly 
305                 310                 315                 320 


Thr Ser Asn Lys Glu Asp Glu Phe Arg Met Pro Tyr Leu Ser His Gln 
                325                 330                 335     


Gln Leu Pro Ala Gly Ile Leu Pro Met Val Pro Glu Val Ala Gln Ala 
            340                 345                 350         


Val Gly Val Ser Gln Gly His His Thr Lys Asp Phe Thr Arg Ala Ala 
        355                 360                 365             


Pro Asn Pro Ala Lys Ala Thr Val Thr Ala Met Ile Ala Arg Glu Leu 
    370                 375                 380                 


Leu Tyr Gly Gly Thr Ser Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn 
385                 390                 395                 400 


Ile Ser Ser Gly His Val Pro His Gly Pro Leu Thr Arg Pro Ser Glu 
                405                 410                 415     


Gln Leu Asp Tyr Leu Ser Arg Val Gln Gly Phe Gln Val Glu Tyr Lys 
            420                 425                 430         


Asp Phe Pro Lys Asn Asn Lys Asn Glu Phe Val Ser Leu Ile Asn Cys 
        435                 440                 445             


Ser Ser Gln Pro Pro Leu Ile Ser His Gly Ile Gly Lys Asp Val Glu 
    450                 455                 460                 


Ser Cys His Asp Met Ala Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu 
465                 470                 475                 480 


Leu Asp Gln Gln Ser Thr Glu Met Pro Arg Thr Gly Asn Gly Pro Met 
                485                 490                 495     


Ser Val Cys Gly Arg Cys 
            500         


<210> 6286
<211> 496
<212> PRT
<213> Homo sapiens

<400> 6286
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser Gly 
        115                 120                 125             


Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu Phe 
    130                 135                 140                 


Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn Ala 
145                 150                 155                 160 


Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro Ala 
                165                 170                 175     


Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile Val 
            180                 185                 190         


Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile Ser 
        195                 200                 205             


Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu Tyr 
    210                 215                 220                 


Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val Met 
225                 230                 235                 240 


Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn Lys 
                245                 250                 255     


Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu Gly 
            260                 265                 270         


Phe Lys Val Pro Gln Ala Gln Pro Thr Lys Pro Ala Leu Lys Ser Glu 
        275                 280                 285             


Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr Phe 
    290                 295                 300                 


Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu Asp 
305                 310                 315                 320 


Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly Ile 
                325                 330                 335     


Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln Gly 
            340                 345                 350         


His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys Ala 
        355                 360                 365             


Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr Ser 
    370                 375                 380                 


Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His Val 
385                 390                 395                 400 


Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu Ser 
                405                 410                 415     


Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn Asn 
            420                 425                 430         


Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro Leu 
        435                 440                 445             


Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met Ala 
    450                 455                 460                 


Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser Thr 
465                 470                 475                 480 


Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg Cys 
                485                 490                 495     


<210> 6287
<211> 490
<212> PRT
<213> Homo sapiens

<400> 6287
Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210> 6288
<211> 490
<212> PRT
<213> Homo sapiens

<400> 6288
Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210> 6289
<211> 502
<212> PRT
<213> Homo sapiens

<400> 6289
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Ser Phe Pro Leu Lys Gln 
        115                 120                 125             


Val Ala Arg Glu Ser Gly Pro Pro His Met Lys Asn Phe Val Thr Lys 
    130                 135                 140                 


Val Ser Val Gly Glu Phe Val Gly Glu Gly Glu Gly Lys Ser Lys Lys 
145                 150                 155                 160 


Ile Ser Lys Lys Asn Ala Ala Ile Ala Val Leu Glu Glu Leu Lys Lys 
                165                 170                 175     


Leu Pro Pro Leu Pro Ala Val Glu Arg Val Lys Pro Arg Ile Lys Lys 
            180                 185                 190         


Lys Thr Lys Pro Ile Val Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln 
        195                 200                 205             


Gly Ile Asn Pro Ile Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys 
    210                 215                 220                 


Glu Lys Glu Pro Glu Tyr Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg 
225                 230                 235                 240 


Arg Arg Glu Phe Val Met Gln Val Lys Val Gly Asn His Thr Ala Glu 
                245                 250                 255     


Gly Thr Gly Thr Asn Lys Lys Val Ala Lys Arg Asn Ala Ala Glu Asn 
            260                 265                 270         


Met Leu Glu Ile Leu Gly Phe Lys Val Pro Gln Ala Gln Pro Thr Lys 
        275                 280                 285             


Pro Ala Leu Lys Ser Glu Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp 
    290                 295                 300                 


Gly Arg Lys Val Thr Phe Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly 
305                 310                 315                 320 


Thr Ser Asn Lys Glu Asp Glu Phe Arg Met Pro Tyr Leu Ser His Gln 
                325                 330                 335     


Gln Leu Pro Ala Gly Ile Leu Pro Met Val Pro Glu Val Ala Gln Ala 
            340                 345                 350         


Val Gly Val Ser Gln Gly His His Thr Lys Asp Phe Thr Arg Ala Ala 
        355                 360                 365             


Pro Asn Pro Ala Lys Ala Thr Val Thr Ala Met Ile Ala Arg Glu Leu 
    370                 375                 380                 


Leu Tyr Gly Gly Thr Ser Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn 
385                 390                 395                 400 


Ile Ser Ser Gly His Val Pro His Gly Pro Leu Thr Arg Pro Ser Glu 
                405                 410                 415     


Gln Leu Asp Tyr Leu Ser Arg Val Gln Gly Phe Gln Val Glu Tyr Lys 
            420                 425                 430         


Asp Phe Pro Lys Asn Asn Lys Asn Glu Phe Val Ser Leu Ile Asn Cys 
        435                 440                 445             


Ser Ser Gln Pro Pro Leu Ile Ser His Gly Ile Gly Lys Asp Val Glu 
    450                 455                 460                 


Ser Cys His Asp Met Ala Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu 
465                 470                 475                 480 


Leu Asp Gln Gln Ser Thr Glu Met Pro Arg Thr Gly Asn Gly Pro Met 
                485                 490                 495     


Ser Val Cys Gly Arg Cys 
            500         


<210> 6290
<211> 217
<212> PRT
<213> Homo sapiens

<400> 6290
Met Ala Glu Gly Ser Gln Ser Ala Pro Glu Ala Gly Asn Asp Met Gly 
1               5                   10                  15      


Asn Asp Asp Ala Ile Gly Gly Asn Val Ser Lys Tyr Ile Val Leu Pro 
            20                  25                  30          


Thr Gly Tyr Cys Gly Gln Pro Lys Lys Gly His Leu Ile Phe Asp Ala 
        35                  40                  45              


Cys Phe Glu Ser Gly Asn Leu Gly Arg Val Asp Gln Val Ser Glu Phe 
    50                  55                  60                  


Glu Tyr Asp Leu Phe Ile Arg Pro Asp Thr Cys Asn Pro Arg Phe Arg 
65                  70                  75                  80  


Val Trp Phe Asn Phe Thr Val Glu Asn Val Lys Glu Ser Gln Arg Val 
                85                  90                  95      


Ile Phe Asn Ile Val Asn Phe Ser Lys Thr Lys Ser Leu Tyr Arg Asp 
            100                 105                 110         


Gly Met Ala Pro Met Val Lys Ser Thr Ser Arg Pro Lys Trp Gln Arg 
        115                 120                 125             


Leu Pro Pro Lys Asn Val Tyr Tyr Tyr Arg Cys Pro Asp His Arg Lys 
    130                 135                 140                 


Asn Tyr Val Met Ser Phe Ala Phe Cys Phe Asp Arg Glu Glu Asp Ile 
145                 150                 155                 160 


Tyr Gln Phe Ala Tyr Cys Tyr Pro Tyr Thr Tyr Thr Arg Phe Gln His 
                165                 170                 175     


Tyr Leu Asp Ser Leu Gln Lys Arg Asn Met Asp Tyr Phe Phe Arg Glu 
            180                 185                 190         


Gln Leu Gly Gln Ser Val Gln Gln Arg Lys Leu Asp Leu Leu Thr Ile 
        195                 200                 205             


Thr Ser Pro Ala Gly Arg Trp Ser Trp 
    210                 215         


<210> 6291
<211> 320
<212> PRT
<213> Homo sapiens

<400> 6291
Met Ala Glu Gly Ser Gln Ser Ala Pro Glu Ala Gly Asn Asp Met Gly 
1               5                   10                  15      


Asn Asp Asp Ala Ile Gly Gly Asn Val Ser Lys Tyr Ile Val Leu Pro 
            20                  25                  30          


Thr Gly Tyr Cys Gly Gln Pro Lys Lys Gly His Leu Ile Phe Asp Ala 
        35                  40                  45              


Cys Phe Glu Ser Gly Asn Leu Gly Arg Val Asp Gln Val Ser Glu Phe 
    50                  55                  60                  


Glu Tyr Asp Leu Phe Ile Arg Pro Asp Thr Cys Asn Pro Arg Phe Arg 
65                  70                  75                  80  


Val Trp Phe Asn Phe Thr Val Glu Asn Val Lys Glu Ser Gln Arg Val 
                85                  90                  95      


Ile Phe Asn Ile Val Asn Phe Ser Lys Thr Lys Ser Leu Tyr Arg Asp 
            100                 105                 110         


Gly Met Ala Pro Met Val Lys Ser Thr Ser Arg Pro Lys Trp Gln Arg 
        115                 120                 125             


Leu Pro Pro Lys Asn Val Tyr Tyr Tyr Arg Cys Pro Asp His Arg Lys 
    130                 135                 140                 


Asn Tyr Val Met Ser Phe Ala Phe Cys Phe Asp Arg Glu Glu Asp Ile 
145                 150                 155                 160 


Tyr Gln Phe Ala Tyr Cys Tyr Pro Tyr Thr Tyr Thr Arg Phe Gln His 
                165                 170                 175     


Tyr Leu Asp Ser Leu Gln Lys Arg Asn Met Asp Tyr Phe Phe Arg Glu 
            180                 185                 190         


Gln Leu Gly Gln Ser Val Gln Gln Arg Lys Leu Asp Leu Leu Thr Ile 
        195                 200                 205             


Thr Ser Pro Asp Asn Leu Arg Glu Gly Ala Glu Gln Lys Val Val Phe 
    210                 215                 220                 


Ile Thr Gly Arg Val His Pro Gly Glu Thr Pro Ser Ser Phe Val Cys 
225                 230                 235                 240 


Gln Gly Ile Ile Asp Phe Leu Val Ser Gln His Pro Ile Ala Cys Val 
                245                 250                 255     


Leu Arg Glu Tyr Leu Val Phe Lys Ile Ala Pro Met Leu Asn Pro Asp 
            260                 265                 270         


Gly Val Tyr Leu Gly Asn Tyr Arg Cys Ser Leu Met Gly Phe Asp Leu 
        275                 280                 285             


Asn Arg His Trp Leu Asp Pro Ser Pro Trp Val His Pro Thr Leu His 
    290                 295                 300                 


Gly Val Lys Gln Leu Ile Val Gln Met Tyr Asn Asp Pro Val Ser Asn 
305                 310                 315                 320 


<210> 6292
<211> 503
<212> PRT
<213> Homo sapiens

<400> 6292
Met Ala Glu Gly Ser Gln Ser Ala Pro Glu Ala Gly Asn Asp Met Gly 
1               5                   10                  15      


Asn Asp Asp Ala Ile Gly Gly Asn Val Ser Lys Tyr Ile Val Leu Pro 
            20                  25                  30          


Thr Gly Tyr Cys Gly Gln Pro Lys Lys Gly His Leu Ile Phe Asp Ala 
        35                  40                  45              


Cys Phe Glu Ser Gly Asn Leu Gly Arg Val Asp Gln Val Ser Glu Phe 
    50                  55                  60                  


Glu Tyr Asp Leu Phe Ile Arg Pro Asp Thr Cys Asn Pro Arg Phe Arg 
65                  70                  75                  80  


Val Trp Phe Asn Phe Thr Val Glu Asn Val Lys Glu Ser Gln Arg Val 
                85                  90                  95      


Ile Phe Asn Ile Val Asn Phe Ser Lys Thr Lys Ser Leu Tyr Arg Asp 
            100                 105                 110         


Gly Met Ala Pro Met Val Lys Ser Thr Ser Arg Pro Lys Trp Gln Arg 
        115                 120                 125             


Leu Pro Pro Lys Asn Val Tyr Tyr Tyr Arg Cys Pro Asp His Arg Lys 
    130                 135                 140                 


Asn Tyr Val Met Ser Phe Ala Phe Cys Phe Asp Arg Glu Glu Asp Ile 
145                 150                 155                 160 


Tyr Gln Phe Ala Tyr Cys Tyr Pro Tyr Thr Tyr Thr Arg Phe Gln His 
                165                 170                 175     


Tyr Leu Asp Ser Leu Gln Lys Arg Asn Met Asp Tyr Phe Phe Arg Glu 
            180                 185                 190         


Gln Leu Gly Gln Ser Val Gln Gln Arg Lys Leu Asp Leu Leu Thr Ile 
        195                 200                 205             


Thr Ser Pro Asp Asn Leu Arg Glu Gly Ala Glu Gln Lys Val Val Phe 
    210                 215                 220                 


Ile Thr Gly Arg Val His Pro Gly Glu Thr Pro Ser Ser Phe Val Cys 
225                 230                 235                 240 


Gln Gly Ile Ile Asp Phe Leu Val Ser Gln His Pro Ile Ala Cys Val 
                245                 250                 255     


Leu Arg Glu Tyr Leu Val Phe Lys Ile Ala Pro Met Leu Asn Pro Asp 
            260                 265                 270         


Gly Val Tyr Leu Gly Asn Tyr Arg Cys Ser Leu Met Gly Phe Asp Leu 
        275                 280                 285             


Asn Arg His Trp Leu Asp Pro Ser Pro Trp Val His Pro Thr Leu His 
    290                 295                 300                 


Gly Val Lys Gln Leu Ile Val Gln Met Tyr Asn Asp Pro Lys Thr Ser 
305                 310                 315                 320 


Leu Glu Phe Tyr Ile Asp Ile His Ala His Ser Thr Met Met Asn Gly 
                325                 330                 335     


Phe Met Tyr Gly Asn Ile Phe Glu Asp Glu Glu Arg Phe Gln Arg Gln 
            340                 345                 350         


Ala Ile Phe Pro Lys Leu Leu Cys Gln Asn Ala Glu Asp Phe Ser Tyr 
        355                 360                 365             


Ser Ser Thr Ser Phe Asn Arg Asp Ala Val Lys Ala Gly Thr Gly Arg 
    370                 375                 380                 


Arg Phe Leu Gly Gly Leu Leu Asp His Thr Ser Tyr Cys Tyr Thr Leu 
385                 390                 395                 400 


Glu Val Ser Phe Tyr Ser Tyr Ile Ile Ser Gly Thr Thr Ala Ala Val 
                405                 410                 415     


Pro Tyr Thr Glu Glu Ala Tyr Met Lys Leu Gly Arg Asn Val Ala Arg 
            420                 425                 430         


Thr Phe Leu Asp Tyr Tyr Arg Leu Asn Pro Val Val Glu Lys Val Ala 
        435                 440                 445             


Ile Pro Met Pro Arg Leu Arg Asn Lys Glu Ile Glu Val Gln Arg Arg 
    450                 455                 460                 


Lys Glu Lys Ser Pro Pro Tyr Lys His Pro Leu Leu Arg Gly Pro Ala 
465                 470                 475                 480 


Ser Asn Tyr Pro Asn Ser Lys Gly Asp Lys Lys Ser Ser Val Asn His 
                485                 490                 495     


Lys Asp Pro Ser Thr Pro Phe 
            500             


<210> 6293
<211> 577
<212> PRT
<213> Homo sapiens

<400> 6293
Met Ser Gln Val Gln Val Gln Val Gln Asn Pro Ser Ala Ala Leu Ser 
1               5                   10                  15      


Gly Ser Gln Ile Leu Asn Lys Asn Gln Ser Leu Leu Ser Gln Pro Leu 
            20                  25                  30          


Met Ser Ile Pro Ser Thr Thr Ser Ser Leu Pro Ser Glu Asn Ala Gly 
        35                  40                  45              


Arg Pro Ile Gln Asn Ser Ala Leu Pro Ser Ala Ser Ile Thr Ser Thr 
    50                  55                  60                  


Ser Ala Ala Ala Glu Ser Ile Thr Pro Thr Val Glu Leu Asn Ala Leu 
65                  70                  75                  80  


Cys Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr 
                85                  90                  95      


Ser Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr 
            100                 105                 110         


Pro Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln 
        115                 120                 125             


Val Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr 
    130                 135                 140                 


Arg Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu 
145                 150                 155                 160 


Gln Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser 
                165                 170                 175     


Glu Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile 
            180                 185                 190         


Ala Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser 
        195                 200                 205             


Gly Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu 
    210                 215                 220                 


Phe Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn 
225                 230                 235                 240 


Ala Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro 
                245                 250                 255     


Ala Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile 
            260                 265                 270         


Val Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile 
        275                 280                 285             


Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu 
    290                 295                 300                 


Tyr Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val 
305                 310                 315                 320 


Met Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn 
                325                 330                 335     


Lys Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu 
            340                 345                 350         


Gly Phe Lys Val Pro Gln Ala Gln Pro Thr Lys Pro Ala Leu Lys Ser 
        355                 360                 365             


Glu Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr 
    370                 375                 380                 


Phe Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu 
385                 390                 395                 400 


Asp Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly 
                405                 410                 415     


Ile Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln 
            420                 425                 430         


Gly His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys 
        435                 440                 445             


Ala Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr 
    450                 455                 460                 


Ser Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His 
465                 470                 475                 480 


Val Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu 
                485                 490                 495     


Ser Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn 
            500                 505                 510         


Asn Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro 
        515                 520                 525             


Leu Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met 
    530                 535                 540                 


Ala Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser 
545                 550                 555                 560 


Thr Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg 
                565                 570                 575     


Cys 
    


<210> 6294
<211> 283
<212> PRT
<213> Homo sapiens

<400> 6294
Met Ser Gly Ala Val Leu Leu Glu Arg Glu Arg Leu Thr Ser Gly Thr 
1               5                   10                  15      


Thr Trp His Thr Ala Gly Leu Leu Trp Gln Leu Arg Pro Ser Asp Val 
            20                  25                  30          


Glu Val Glu Leu Leu Ala His Thr Arg Arg Val Val Ser Arg Glu Leu 
        35                  40                  45              


Glu Glu Glu Thr Gly Leu His Thr Gly Trp Ile Gln Asn Gly Gly Leu 
    50                  55                  60                  


Phe Ile Ala Ser Asn Arg Gln Arg Leu Asp Glu Tyr Lys Arg Leu Met 
65                  70                  75                  80  


Ser Leu Gly Lys Ala Tyr Gly Val Glu Ser His Val Leu Ser Pro Ala 
                85                  90                  95      


Glu Thr Lys Thr Leu Tyr Pro Leu Met Asn Val Asp Asp Leu Tyr Gly 
            100                 105                 110         


Thr Leu Tyr Val Pro His Asp Gly Thr Met Asp Pro Ala Gly Thr Cys 
        115                 120                 125             


Thr Thr Leu Ala Arg Ala Ala Ser Ala Arg Gly Ala Gln Val Ile Glu 
    130                 135                 140                 


Asn Cys Pro Val Thr Gly Ile Arg Val Trp Thr Asp Asp Phe Gly Val 
145                 150                 155                 160 


Arg Arg Val Ala Gly Val Glu Thr Gln His Gly Ser Ile Gln Thr Pro 
                165                 170                 175     


Cys Val Val Asn Cys Ala Gly Val Trp Ala Ser Ala Val Gly Arg Met 
            180                 185                 190         


Ala Gly Val Lys Val Pro Leu Val Ala Met His His Ala Tyr Val Val 
        195                 200                 205             


Thr Glu Arg Ile Glu Gly Ile Gln Asn Met Pro Asn Val Arg Asp His 
    210                 215                 220                 


Asp Ala Ser Val Tyr Leu Arg Leu Gln Gly Asp Ala Leu Ser Val Gly 
225                 230                 235                 240 


Gly Tyr Glu Ala Asn Pro Ile Phe Trp Glu Glu Ala Val Lys Tyr Arg 
                245                 250                 255     


Pro Arg Ala Ala Gly Gly Leu Cys Leu Lys Thr Ser Thr Glu Lys Val 
            260                 265                 270         


Cys Ala Val Trp Ser Asp Asp Leu Arg Arg Ala 
        275                 280             


<210> 6295
<211> 368
<212> PRT
<213> Homo sapiens

<400> 6295
Met Ser Tyr Phe Gly Lys Phe Tyr Leu Val Gly Leu Asp Ala Arg Lys 
1               5                   10                  15      


Ala Ala Asp Trp Leu Phe Ser Ala Asp Val Ser Arg Pro Pro Gly Ser 
            20                  25                  30          


Thr Val Tyr Thr Cys Met Leu Asn His Arg Gly Gly Thr Glu Ser Asp 
        35                  40                  45              


Leu Thr Val Ser Arg Leu Ala Pro Ser His Gln Ala Ser Pro Leu Ala 
    50                  55                  60                  


Pro Ala Phe Glu Gly Asp Gly Tyr Tyr Leu Ala Met Gly Gly Ala Val 
65                  70                  75                  80  


Ala Gln His Asn Trp Ser His Ile Thr Thr Val Leu Gln Asp Gln Lys 
                85                  90                  95      


Ser Gln Cys Gln Leu Ile Asp Ser Ser Glu Asp Leu Gly Met Ile Ser 
            100                 105                 110         


Ile Gln Gly Pro Ala Ser Arg Ala Ile Leu Gln Glu Val Leu Asp Ala 
        115                 120                 125             


Asp Leu Ser Asn Glu Ala Phe Pro Phe Ser Thr His Lys Leu Leu Arg 
    130                 135                 140                 


Ala Ala Gly His Leu Val Arg Ala Met Arg Leu Ser Phe Val Gly Glu 
145                 150                 155                 160 


Leu Gly Trp Glu Leu His Ile Pro Lys Ala Ser Cys Val Pro Val Tyr 
                165                 170                 175     


Arg Ala Val Met Ala Ala Gly Ala Lys His Gly Leu Ile Asn Ala Gly 
            180                 185                 190         


Tyr Arg Ala Ile Asp Ser Leu Ser Ile Glu Lys Gly Tyr Arg His Trp 
        195                 200                 205             


His Ala Asp Leu Arg Pro Asp Asp Ser Pro Leu Glu Ala Gly Leu Ala 
    210                 215                 220                 


Phe Thr Cys Lys Leu Lys Ser Pro Val Pro Phe Leu Gly Arg Glu Ala 
225                 230                 235                 240 


Leu Glu Gln Gln Arg Ala Ala Gly Leu Arg Arg Arg Leu Val Cys Phe 
                245                 250                 255     


Thr Met Glu Glu Pro Leu Trp Thr Arg Pro His Pro Ala Val Ser Gly 
            260                 265                 270         


Ala Pro Ala Phe Ser Thr Ala Ser Ser Ser Lys Val Pro Met Phe Gly 
        275                 280                 285             


Leu Glu Ala Ile Trp Arg Asn Gly Gln Val Val Gly His Val Arg Arg 
    290                 295                 300                 


Ala Asp Phe Gly Phe Ala Ile Asp Lys Thr Ile Ala Tyr Gly Tyr Ile 
305                 310                 315                 320 


His Asp Pro Ser Gly Gly Pro Val Ser Leu Asp Phe Val Lys Ser Gly 
                325                 330                 335     


Asp Tyr Ala Leu Glu Arg Met Gly Val Thr Tyr Gly Ala Gln Ala His 
            340                 345                 350         


Leu Lys Ser Pro Phe Asp Pro Asn Asn Lys Arg Val Lys Gly Ile Tyr 
        355                 360                 365             


<210> 6296
<211> 918
<212> PRT
<213> Homo sapiens

<400> 6296
Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg 
1               5                   10                  15      


Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala 
            20                  25                  30          


Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu 
        35                  40                  45              


Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro 
    50                  55                  60                  


Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln 
65                  70                  75                  80  


Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu 
                85                  90                  95      


Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu 
            100                 105                 110         


Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His 
        115                 120                 125             


Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His 
    130                 135                 140                 


Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly 
                165                 170                 175     


Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro 
            180                 185                 190         


Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp 
        195                 200                 205             


Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala 
    210                 215                 220                 


Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile 
225                 230                 235                 240 


Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu 
                245                 250                 255     


Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly 
            260                 265                 270         


Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu 
        275                 280                 285             


Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile 
    290                 295                 300                 


Gln Asn Met Pro Asn Val Arg Asp His Asp Ala Ser Val Tyr Leu Arg 
305                 310                 315                 320 


Leu Gln Gly Asp Ala Leu Ser Val Gly Gly Tyr Glu Ala Asn Pro Ile 
                325                 330                 335     


Phe Trp Glu Glu Val Ser Asp Lys Phe Ala Phe Gly Leu Phe Asp Leu 
            340                 345                 350         


Asp Trp Glu Val Phe Thr Gln His Ile Glu Gly Ala Ile Asn Arg Val 
        355                 360                 365             


Pro Val Leu Glu Lys Thr Gly Ile Lys Ser Thr Val Cys Gly Pro Glu 
    370                 375                 380                 


Ser Phe Thr Pro Asp His Lys Pro Leu Met Gly Glu Ala Pro Glu Leu 
385                 390                 395                 400 


Arg Gly Phe Phe Leu Gly Cys Gly Phe Asn Ser Ala Gly Met Met Leu 
                405                 410                 415     


Gly Gly Gly Cys Gly Gln Glu Leu Ala His Trp Ile Ile His Gly Arg 
            420                 425                 430         


Pro Glu Lys Asp Met His Gly Tyr Asp Ile Arg Arg Phe His His Ser 
        435                 440                 445             


Leu Thr Asp His Pro Arg Trp Ile Arg Glu Arg Ser His Glu Ser Tyr 
    450                 455                 460                 


Ala Lys Asn Tyr Ser Val Val Phe Pro His Asp Glu Pro Leu Ala Gly 
465                 470                 475                 480 


Arg Asn Met Arg Arg Asp Pro Leu His Glu Glu Leu Leu Gly Gln Gly 
                485                 490                 495     


Cys Val Phe Gln Glu Arg His Gly Trp Glu Arg Pro Gly Trp Phe His 
            500                 505                 510         


Pro Arg Gly Pro Ala Pro Val Leu Glu Tyr Asp Tyr Tyr Gly Ala Tyr 
        515                 520                 525             


Gly Ser Arg Ala His Glu Asp Tyr Ala Tyr Arg Arg Leu Leu Ala Asp 
    530                 535                 540                 


Glu Tyr Thr Phe Ala Phe Pro Pro His His Asp Thr Ile Lys Lys Glu 
545                 550                 555                 560 


Cys Leu Ala Cys Arg Gly Ala Ala Ala Val Phe Asp Met Ser Tyr Phe 
                565                 570                 575     


Gly Lys Phe Tyr Leu Val Gly Leu Asp Ala Arg Lys Ala Ala Asp Trp 
            580                 585                 590         


Leu Phe Ser Ala Asp Val Ser Arg Pro Pro Gly Ser Thr Val Tyr Thr 
        595                 600                 605             


Cys Met Leu Asn His Arg Gly Gly Thr Glu Ser Asp Leu Thr Val Ser 
    610                 615                 620                 


Arg Leu Ala Pro Ser His Gln Ala Ser Pro Leu Ala Pro Ala Phe Glu 
625                 630                 635                 640 


Gly Asp Gly Tyr Tyr Leu Ala Met Gly Gly Ala Val Ala Gln His Asn 
                645                 650                 655     


Trp Ser His Ile Thr Thr Val Leu Gln Asp Gln Lys Ser Gln Cys Gln 
            660                 665                 670         


Leu Ile Asp Ser Ser Glu Asp Leu Gly Met Ile Ser Ile Gln Gly Pro 
        675                 680                 685             


Ala Ser Arg Ala Ile Leu Gln Glu Val Leu Asp Ala Asp Leu Ser Asn 
    690                 695                 700                 


Glu Ala Phe Pro Phe Ser Thr His Lys Leu Leu Arg Ala Ala Gly His 
705                 710                 715                 720 


Leu Val Arg Ala Met Arg Leu Ser Phe Val Gly Glu Leu Gly Trp Glu 
                725                 730                 735     


Leu His Ile Pro Lys Ala Ser Cys Val Pro Val Tyr Arg Ala Val Met 
            740                 745                 750         


Ala Ala Gly Ala Lys His Gly Leu Ile Asn Ala Gly Tyr Arg Ala Ile 
        755                 760                 765             


Asp Ser Leu Ser Ile Glu Lys Gly Tyr Arg His Trp His Ala Asp Leu 
    770                 775                 780                 


Arg Pro Asp Asp Ser Pro Leu Glu Ala Gly Leu Ala Phe Thr Cys Lys 
785                 790                 795                 800 


Leu Lys Ser Pro Val Pro Phe Leu Gly Arg Glu Ala Leu Glu Gln Gln 
                805                 810                 815     


Arg Ala Ala Gly Leu Arg Arg Arg Leu Val Cys Phe Thr Met Glu Asp 
            820                 825                 830         


Lys Val Pro Met Phe Gly Leu Glu Ala Ile Trp Arg Asn Gly Gln Val 
        835                 840                 845             


Val Gly His Val Arg Arg Ala Asp Phe Gly Phe Ala Ile Asp Lys Thr 
    850                 855                 860                 


Ile Ala Tyr Gly Tyr Ile His Asp Pro Ser Gly Gly Pro Val Ser Leu 
865                 870                 875                 880 


Asp Phe Val Lys Ser Gly Asp Tyr Ala Leu Glu Arg Met Gly Val Thr 
                885                 890                 895     


Tyr Gly Ala Gln Ala His Leu Lys Ser Pro Phe Asp Pro Asn Asn Lys 
            900                 905                 910         


Arg Val Lys Gly Ile Tyr 
        915             


<210> 6297
<211> 239
<212> PRT
<213> Homo sapiens

<400> 6297
Met Glu Gly Thr Val Glu Ser Gln Thr Pro Asp Leu Arg Asp Val Glu 
1               5                   10                  15      


Gly Lys Val Gly Arg Lys Thr Pro Glu Gly Leu Leu Arg Gly Leu Arg 
            20                  25                  30          


Gly Glu Cys Glu Leu Gly Thr Ser Gly Ala Leu Leu Leu Pro Gly Ala 
        35                  40                  45              


Ser Ser Thr Gly His Asp Leu Gly Asp Lys Ile Met Ala Leu Lys Met 
    50                  55                  60                  


Glu Leu Ala Tyr Leu Arg Ala Ile Asp Val Lys Ile Leu Gln Gln Leu 
65                  70                  75                  80  


Val Thr Leu Asn Glu Gly Ile Glu Ala Val Arg Trp Leu Leu Glu Glu 
                85                  90                  95      


Arg Gly Thr Leu Thr Ser His Cys Ser Ser Leu Thr Ser Ser Gln Tyr 
            100                 105                 110         


Ser Leu Thr Gly Gly Ser Pro Gly Arg Ser Arg Arg Gly Ser Trp Asp 
        115                 120                 125             


Ser Leu Pro Asp Thr Ser Thr Thr Asp Arg Leu Asp Ser Val Ser Ile 
    130                 135                 140                 


Gly Ser Phe Leu Asp Thr Val Ala Pro Ser Glu Leu Asp Glu Gln Gly 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Arg Ser Glu Met Asp Trp Ala Lys Val Ile Ala 
                165                 170                 175     


Gly Gly Glu Arg Ala Arg Thr Glu Val Asp Val Ala Ala Thr Arg Leu 
            180                 185                 190         


Gly Ser Leu Arg Ala Val Trp Lys Pro Pro Gly Glu Arg Leu Gln Gly 
        195                 200                 205             


Gly Pro Pro Glu Ser Pro Glu Asp Glu Ser Ala Lys Leu Gly Phe Glu 
    210                 215                 220                 


Ala His Trp Phe Trp Glu Gln Cys Gln Asp Asp Val Thr Phe Leu 
225                 230                 235                 


<210> 6298
<211> 97
<212> PRT
<213> Homo sapiens

<400> 6298
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Asp Glu Gly Ile Ser Phe Arg Gly Leu Phe Ile Ile Asp 
            20                  25                  30          


Asp Lys Gly Ile Leu Arg Gln Ile Thr Val Asn Asp Leu Pro Val Gly 
        35                  40                  45              


Arg Ser Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Phe Thr 
    50                  55                  60                  


Asp Lys His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Asp 
65                  70                  75                  80  


Thr Ile Lys Pro Asp Val Gln Lys Ser Lys Glu Tyr Phe Ser Lys Gln 
                85                  90                  95      


Lys 
    


<210> 6299
<211> 555
<212> PRT
<213> Homo sapiens

<400> 6299
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val 
1               5                   10                  15      


Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val 
            20                  25                  30          


Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser 
        35                  40                  45              


Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile 
    50                  55                  60                  


Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser 
65                  70                  75                  80  


Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala 
                85                  90                  95      


Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn 
            100                 105                 110         


Ile Leu Arg Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser 
        115                 120                 125             


Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile 
    130                 135                 140                 


Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp 
145                 150                 155                 160 


Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser 
                165                 170                 175     


Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser 
            180                 185                 190         


Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala 
        195                 200                 205             


Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe 
    210                 215                 220                 


Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp 
225                 230                 235                 240 


Pro Asp Tyr Leu Pro Arg Thr Glu Asn Phe Gly Leu Asp Tyr Asp Ala 
                245                 250                 255     


Phe Gln His Met Val Gly Asp Cys Pro Pro Asp Phe Leu Gln Leu Thr 
            260                 265                 270         


Phe Asn Cys Cys Asn Met Asp Pro Lys Leu Arg Pro Ser Phe Val Glu 
        275                 280                 285             


Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln Glu Glu Glu 
    290                 295                 300                 


Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly Leu Leu Glu 
305                 310                 315                 320 


Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp Lys Ile Pro 
                325                 330                 335     


His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser Arg Ser Gln 
            340                 345                 350         


Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser Val Leu Asp 
        355                 360                 365             


Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro Lys Val Asn 
    370                 375                 380                 


Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile Lys Phe Phe 
385                 390                 395                 400 


Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp Leu Asp Ala 
                405                 410                 415     


Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu Pro Leu Ala 
            420                 425                 430         


Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro Glu Phe Leu 
        435                 440                 445             


His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser Leu Ser Asp 
    450                 455                 460                 


Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val Lys Glu Ile 
465                 470                 475                 480 


Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala His Glu Ala 
                485                 490                 495     


Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly Ser Arg Pro 
            500                 505                 510         


Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu Met Glu Val 
        515                 520                 525             


Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser Thr Ser Gly 
    530                 535                 540                 


Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly 
545                 550                 555 


<210> 6300
<211> 542
<212> PRT
<213> Homo sapiens

<400> 6300
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val 
1               5                   10                  15      


Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val 
            20                  25                  30          


Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser 
        35                  40                  45              


Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile 
    50                  55                  60                  


Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser 
65                  70                  75                  80  


Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala 
                85                  90                  95      


Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn 
            100                 105                 110         


Ile Leu Arg Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala 
        115                 120                 125             


Leu Thr Glu Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser 
    130                 135                 140                 


Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile 
145                 150                 155                 160 


Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp 
                165                 170                 175     


Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser 
            180                 185                 190         


Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser 
        195                 200                 205             


Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala 
    210                 215                 220                 


Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe 
225                 230                 235                 240 


Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp 
                245                 250                 255     


Pro Asp Tyr Leu Pro Arg Thr Glu Met Asp Pro Lys Leu Arg Pro Ser 
            260                 265                 270         


Phe Val Glu Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln 
        275                 280                 285             


Glu Glu Glu Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly 
    290                 295                 300                 


Leu Leu Glu Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp 
305                 310                 315                 320 


Lys Ile Pro His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser 
                325                 330                 335     


Arg Ser Gln Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser 
            340                 345                 350         


Val Leu Asp Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro 
        355                 360                 365             


Lys Val Asn Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile 
    370                 375                 380                 


Lys Phe Phe Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp 
385                 390                 395                 400 


Leu Asp Ala Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu 
                405                 410                 415     


Pro Leu Ala Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro 
            420                 425                 430         


Glu Phe Leu His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser 
        435                 440                 445             


Leu Ser Asp Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val 
    450                 455                 460                 


Lys Glu Ile Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala 
465                 470                 475                 480 


His Glu Ala Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly 
                485                 490                 495     


Ser Arg Pro Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu 
            500                 505                 510         


Met Glu Val Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser 
        515                 520                 525             


Thr Ser Gly Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly 
    530                 535                 540         


<210> 6301
<211> 571
<212> PRT
<213> Homo sapiens

<400> 6301
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val 
1               5                   10                  15      


Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val 
            20                  25                  30          


Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser 
        35                  40                  45              


Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile 
    50                  55                  60                  


Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser 
65                  70                  75                  80  


Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala 
                85                  90                  95      


Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn 
            100                 105                 110         


Ile Leu Arg Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala 
        115                 120                 125             


Leu Thr Glu Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser 
    130                 135                 140                 


Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile 
145                 150                 155                 160 


Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp 
                165                 170                 175     


Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser 
            180                 185                 190         


Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser 
        195                 200                 205             


Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala 
    210                 215                 220                 


Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe 
225                 230                 235                 240 


Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp 
                245                 250                 255     


Pro Asp Tyr Leu Pro Arg Thr Glu Asn Phe Gly Leu Asp Tyr Asp Ala 
            260                 265                 270         


Phe Gln His Met Val Gly Asp Cys Pro Pro Asp Phe Leu Gln Leu Thr 
        275                 280                 285             


Phe Asn Cys Cys Asn Met Asp Pro Lys Leu Arg Pro Ser Phe Val Glu 
    290                 295                 300                 


Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln Glu Glu Glu 
305                 310                 315                 320 


Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly Leu Leu Glu 
                325                 330                 335     


Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp Lys Ile Pro 
            340                 345                 350         


His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser Arg Ser Gln 
        355                 360                 365             


Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser Val Leu Asp 
    370                 375                 380                 


Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro Lys Val Asn 
385                 390                 395                 400 


Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile Lys Phe Phe 
                405                 410                 415     


Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp Leu Asp Ala 
            420                 425                 430         


Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu Pro Leu Ala 
        435                 440                 445             


Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro Glu Phe Leu 
    450                 455                 460                 


His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser Leu Ser Asp 
465                 470                 475                 480 


Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val Lys Glu Ile 
                485                 490                 495     


Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala His Glu Ala 
            500                 505                 510         


Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly Ser Arg Pro 
        515                 520                 525             


Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu Met Glu Val 
    530                 535                 540                 


Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser Thr Ser Gly 
545                 550                 555                 560 


Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly 
                565                 570     


<210> 6302
<211> 471
<212> PRT
<213> Homo sapiens

<400> 6302
Met Leu Gly Ser Trp Gly Cys Tyr Arg Tyr Ala Lys Leu Phe Ser Cys 
1               5                   10                  15      


Ser Leu Ser Thr His Ala Arg Phe Ile Lys Ile Leu Asp Ser Val Leu 
            20                  25                  30          


His His Leu Val Pro Ala Trp Asp His Thr Leu Gly Thr Phe Ser Glu 
        35                  40                  45              


Ile Lys Gln Val Lys Gln Phe Leu Leu Leu Ser Arg Gln Arg Pro Gly 
    50                  55                  60                  


Leu Val Ala Gln Cys Leu Arg Asp Ser Glu Ser Ser Lys Pro Ser Phe 
65                  70                  75                  80  


Met Pro Arg Leu Tyr Ile Asn Arg Arg Leu Ala Met Glu His Arg Ala 
                85                  90                  95      


Cys Pro Ser Arg Asp Pro Ala Cys Lys Asn Ala Val Phe Thr Gln Val 
            100                 105                 110         


Tyr Glu Gly Leu Lys Pro Ser Asp Lys Tyr Glu Lys Pro Leu Asp Tyr 
        115                 120                 125             


Arg Trp Pro Met Arg Tyr Asp Gln Trp Trp Glu Cys Lys Phe Ile Ala 
    130                 135                 140                 


Glu Gly Ile Ile Asp Gln Gly Gly Gly Phe Arg Asp Ser Leu Ala Asp 
145                 150                 155                 160 


Met Ser Glu Glu Leu Cys Pro Ser Ser Ala Asp Thr Pro Val Pro Leu 
                165                 170                 175     


Pro Phe Phe Val Arg Thr Ala Asn Gln Gly Asn Gly Thr Gly Glu Ala 
            180                 185                 190         


Arg Asp Met Tyr Val Pro Asn Pro Ser Cys Arg Asp Phe Ala Lys Tyr 
        195                 200                 205             


Glu Trp Ile Gly Gln Leu Met Gly Ala Ala Leu Arg Gly Lys Glu Phe 
    210                 215                 220                 


Leu Val Leu Ala Leu Pro Gly Phe Val Trp Lys Gln Leu Ser Gly Glu 
225                 230                 235                 240 


Glu Val Ser Trp Ser Lys Asp Phe Pro Ala Val Asp Ser Val Leu Val 
                245                 250                 255     


Lys Leu Leu Glu Val Met Glu Gly Met Asp Lys Glu Thr Phe Glu Phe 
            260                 265                 270         


Lys Phe Gly Lys Glu Leu Thr Phe Thr Thr Val Leu Ser Asp Gln Gln 
        275                 280                 285             


Val Val Glu Leu Ile Pro Gly Gly Ala Gly Ile Val Val Gly Tyr Gly 
    290                 295                 300                 


Asp Arg Ser Arg Phe Ile Gln Leu Val Gln Lys Ala Arg Leu Glu Glu 
305                 310                 315                 320 


Ser Lys Glu Gln Val Ala Ala Met Gln Ala Gly Leu Leu Lys Val Val 
                325                 330                 335     


Pro Gln Ala Val Leu Asp Leu Leu Thr Trp Gln Glu Leu Glu Lys Lys 
            340                 345                 350         


Val Cys Gly Asp Pro Glu Val Thr Val Asp Ala Leu Arg Lys Leu Thr 
        355                 360                 365             


Arg Phe Glu Asp Phe Glu Pro Ser Asp Ser Arg Val Gln Tyr Phe Trp 
    370                 375                 380                 


Glu Ala Leu Asn Asn Phe Thr Asn Glu Asp Arg Ser Arg Phe Leu Arg 
385                 390                 395                 400 


Phe Val Thr Gly Arg Ser Arg Leu Pro Ala Arg Ile Tyr Ile Tyr Pro 
                405                 410                 415     


Asp Lys Leu Gly Tyr Glu Thr Thr Asp Ala Leu Pro Glu Ser Ser Thr 
            420                 425                 430         


Cys Ser Ser Thr Leu Phe Leu Pro His Tyr Ala Ser Ala Lys Val Cys 
        435                 440                 445             


Glu Glu Lys Leu Arg Tyr Ala Ala Tyr Asn Cys Val Ala Ile Asp Thr 
    450                 455                 460                 


Asp Met Ser Pro Trp Glu Glu 
465                 470     


<210> 6303
<211> 274
<212> PRT
<213> Homo sapiens

<400> 6303
Met Ala Ala Pro Glu Ala Glu Val Leu Ser Ser Ala Ala Val Pro Asp 
1               5                   10                  15      


Leu Glu Trp Tyr Glu Lys Ser Glu Glu Thr His Ala Ser Gln Ile Glu 
            20                  25                  30          


Leu Leu Glu Thr Ser Ser Thr Gln Glu Pro Leu Asn Ala Ser Glu Ala 
        35                  40                  45              


Phe Cys Pro Arg Asp Cys Met Val Pro Val Val Phe Pro Gly Pro Val 
    50                  55                  60                  


Ser Gln Glu Gly Cys Cys Gln Phe Thr Cys Glu Leu Leu Lys His Ile 
65                  70                  75                  80  


Met Tyr Gln Arg Gln Gln Leu Pro Leu Pro Tyr Glu Gln Leu Lys His 
                85                  90                  95      


Phe Tyr Arg Lys Pro Ser Pro Gln Ala Glu Glu Met Leu Lys Lys Lys 
            100                 105                 110         


Pro Arg Ala Thr Thr Glu Val Ser Ser Arg Lys Cys Gln Gln Ala Leu 
        115                 120                 125             


Ala Glu Leu Glu Ser Val Leu Ser His Leu Glu Asp Phe Phe Ala Arg 
    130                 135                 140                 


Thr Leu Val Pro Arg Val Leu Ile Leu Leu Gly Gly Asn Ala Leu Ser 
145                 150                 155                 160 


Pro Lys Glu Phe Tyr Glu Leu Asp Leu Ser Leu Leu Ala Pro Tyr Ser 
                165                 170                 175     


Val Asp Gln Ser Leu Ser Thr Ala Ala Cys Leu Arg Arg Leu Phe Arg 
            180                 185                 190         


Ala Ile Phe Met Ala Asp Ala Phe Ser Glu Leu Gln Ala Pro Pro Leu 
        195                 200                 205             


Met Gly Thr Val Val Met Ala Gln Gly His Arg Asn Cys Gly Glu Asp 
    210                 215                 220                 


Trp Phe Arg Pro Lys Leu Asn Tyr Arg Val Pro Ser Arg Gly His Lys 
225                 230                 235                 240 


Leu Thr Val Thr Leu Ser Cys Gly Arg Pro Ser Ile Arg Thr Thr Ala 
                245                 250                 255     


Trp Glu Asp Tyr Ile Trp Phe Gln Ala Pro Val Thr Phe Lys Gly Phe 
            260                 265                 270         


Arg Glu 
        


<210> 6304
<211> 861
<212> PRT
<213> Homo sapiens

<400> 6304
Met Ala Gly Pro Gly Pro Gly Ala Val Leu Glu Ser Pro Arg Gln Leu 
1               5                   10                  15      


Leu Gly Arg Val Arg Phe Leu Ala Glu Ala Ala Arg Ser Leu Arg Ala 
            20                  25                  30          


Gly Arg Pro Leu Pro Ala Ala Leu Ala Phe Val Pro Arg Glu Val Leu 
        35                  40                  45              


Tyr Lys Leu Tyr Lys Asp Pro Ala Gly Pro Ser Arg Val Leu Leu Pro 
    50                  55                  60                  


Val Trp Glu Ala Glu Gly Leu Gly Leu Arg Val Gly Ala Ala Gly Pro 
65                  70                  75                  80  


Ala Pro Gly Thr Gly Ser Gly Pro Leu Arg Ala Ala Arg Asp Ser Ile 
                85                  90                  95      


Glu Leu Arg Arg Gly Ala Cys Val Arg Thr Thr Gly Glu Glu Leu Cys 
            100                 105                 110         


Asn Gly His Gly Leu Trp Val Lys Leu Thr Lys Glu Gln Leu Ala Glu 
        115                 120                 125             


His Leu Gly Asp Cys Gly Leu Gln Glu Gly Trp Leu Leu Val Cys Arg 
    130                 135                 140                 


Pro Ala Glu Gly Gly Ala Arg Leu Val Pro Ile Asp Thr Pro Asn His 
145                 150                 155                 160 


Leu Gln Arg Gln Gln Gln Leu Phe Gly Val Asp Tyr Arg Pro Val Leu 
                165                 170                 175     


Arg Trp Glu Gln Val Val Asp Leu Thr Tyr Ser His Arg Leu Gly Ser 
            180                 185                 190         


Arg Pro Gln Pro Ala Glu Ala Tyr Ala Glu Ala Val Gln Arg Leu Leu 
        195                 200                 205             


Tyr Val Pro Pro Thr Trp Thr Tyr Glu Cys Asp Glu Asp Leu Ile His 
    210                 215                 220                 


Phe Leu Tyr Asp His Leu Gly Lys Glu Asp Glu Asn Leu Gly Ser Val 
225                 230                 235                 240 


Lys Gln Tyr Val Glu Ser Ile Asp Val Ser Ser Tyr Thr Glu Glu Phe 
                245                 250                 255     


Asn Val Ser Cys Leu Thr Asp Ser Asn Ala Asp Thr Tyr Trp Glu Ser 
            260                 265                 270         


Asp Gly Ser Gln Cys Gln His Trp Val Arg Leu Thr Met Lys Lys Gly 
        275                 280                 285             


Thr Ile Val Lys Lys Leu Leu Leu Thr Val Asp Thr Thr Asp Asp Asn 
    290                 295                 300                 


Phe Met Pro Lys Arg Val Val Val Tyr Gly Gly Glu Gly Asp Asn Leu 
305                 310                 315                 320 


Lys Lys Leu Ser Asp Val Ser Ile Asp Glu Thr Leu Ile Gly Asp Val 
                325                 330                 335     


Cys Val Leu Glu Asp Met Thr Val His Leu Pro Ile Ile Glu Ile Arg 
            340                 345                 350         


Ile Val Glu Cys Arg Asp Asp Gly Ile Asp Val Arg Leu Arg Gly Val 
        355                 360                 365             


Lys Ile Lys Ser Ser Arg Gln Arg Glu Leu Gly Leu Asn Ala Asp Leu 
    370                 375                 380                 


Phe Gln Pro Thr Ser Leu Val Arg Tyr Pro Arg Leu Glu Gly Thr Asp 
385                 390                 395                 400 


Pro Glu Val Leu Tyr Arg Arg Ala Val Leu Leu Gln Arg Phe Ile Lys 
                405                 410                 415     


Ile Leu Asp Ser Val Leu His His Leu Val Pro Ala Trp Asp His Thr 
            420                 425                 430         


Leu Gly Thr Phe Ser Glu Ile Lys Gln Val Lys Gln Phe Leu Leu Leu 
        435                 440                 445             


Ser Arg Gln Arg Pro Gly Leu Val Ala Gln Cys Leu Arg Asp Ser Glu 
    450                 455                 460                 


Ser Ser Lys Pro Ser Phe Met Pro Arg Leu Tyr Ile Asn Arg Arg Leu 
465                 470                 475                 480 


Ala Met Glu His Arg Ala Cys Pro Ser Arg Asp Pro Ala Cys Lys Asn 
                485                 490                 495     


Ala Val Phe Thr Gln Val Tyr Glu Gly Leu Lys Pro Ser Asp Lys Tyr 
            500                 505                 510         


Glu Lys Pro Leu Asp Tyr Arg Trp Pro Met Arg Tyr Asp Gln Trp Trp 
        515                 520                 525             


Glu Cys Lys Phe Ile Ala Glu Gly Ile Ile Asp Gln Gly Gly Gly Phe 
    530                 535                 540                 


Arg Asp Ser Leu Ala Asp Met Ser Glu Glu Leu Cys Pro Ser Ser Ala 
545                 550                 555                 560 


Asp Thr Pro Val Pro Leu Pro Phe Phe Val Arg Thr Ala Asn Gln Gly 
                565                 570                 575     


Asn Gly Thr Gly Glu Ala Arg Asp Met Tyr Val Pro Asn Pro Ser Cys 
            580                 585                 590         


Arg Asp Phe Ala Lys Tyr Glu Trp Ile Gly Gln Leu Met Gly Ala Ala 
        595                 600                 605             


Leu Arg Gly Lys Glu Phe Leu Val Leu Ala Leu Pro Gly Phe Val Trp 
    610                 615                 620                 


Lys Gln Leu Ser Gly Glu Glu Val Ser Trp Ser Lys Asp Phe Pro Ala 
625                 630                 635                 640 


Val Asp Ser Val Leu Val Lys Leu Leu Glu Val Met Glu Gly Met Asp 
                645                 650                 655     


Lys Glu Thr Phe Glu Phe Lys Phe Gly Lys Glu Leu Thr Phe Thr Thr 
            660                 665                 670         


Val Leu Ser Asp Gln Gln Val Val Glu Leu Ile Pro Gly Gly Ala Gly 
        675                 680                 685             


Ile Val Val Gly Tyr Gly Asp Arg Ser Arg Phe Ile Gln Leu Val Gln 
    690                 695                 700                 


Lys Ala Arg Leu Glu Glu Ser Lys Glu Gln Val Ala Ala Met Gln Ala 
705                 710                 715                 720 


Gly Leu Leu Lys Val Val Pro Gln Ala Val Leu Asp Leu Leu Thr Trp 
                725                 730                 735     


Gln Glu Leu Glu Lys Lys Val Cys Gly Asp Pro Glu Val Thr Val Asp 
            740                 745                 750         


Ala Leu Arg Lys Leu Thr Arg Phe Glu Asp Phe Glu Pro Ser Asp Ser 
        755                 760                 765             


Arg Val Gln Tyr Phe Trp Glu Ala Leu Asn Asn Phe Thr Asn Glu Asp 
    770                 775                 780                 


Arg Ser Arg Phe Leu Arg Phe Val Thr Gly Arg Ser Arg Leu Pro Ala 
785                 790                 795                 800 


Arg Ile Tyr Ile Tyr Pro Asp Lys Leu Gly Tyr Glu Thr Thr Asp Ala 
                805                 810                 815     


Leu Pro Glu Ser Ser Thr Cys Ser Ser Thr Leu Phe Leu Pro His Tyr 
            820                 825                 830         


Ala Ser Ala Lys Val Cys Glu Glu Lys Leu Arg Tyr Ala Ala Tyr Asn 
        835                 840                 845             


Cys Val Ala Ile Asp Thr Asp Met Ser Pro Trp Glu Glu 
    850                 855                 860     


<210> 6305
<211> 398
<212> PRT
<213> Homo sapiens

<400> 6305
Met Glu Ser Val Leu Ser Lys Tyr Glu Asp Gln Ile Thr Ile Phe Thr 
1               5                   10                  15      


Asp Tyr Leu Glu Glu Tyr Pro Asp Thr Asp Glu Leu Val Trp Ile Leu 
            20                  25                  30          


Gly Lys Gln His Leu Leu Lys Thr Glu Lys Ser Lys Leu Leu Ser Asp 
        35                  40                  45              


Ile Ser Ala Arg Leu Trp Phe Thr Tyr Arg Arg Lys Phe Ser Pro Ile 
    50                  55                  60                  


Gly Gly Thr Gly Pro Ser Ser Asp Ala Gly Trp Gly Cys Met Leu Arg 
65                  70                  75                  80  


Cys Gly Gln Met Met Leu Ala Gln Ala Leu Ile Cys Arg His Leu Gly 
                85                  90                  95      


Arg Asp Trp Ser Trp Glu Lys Gln Lys Glu Gln Pro Lys Glu Tyr Gln 
            100                 105                 110         


Arg Ile Leu Gln Cys Phe Leu Asp Arg Lys Asp Cys Cys Tyr Ser Ile 
        115                 120                 125             


His Gln Met Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Glu 
    130                 135                 140                 


Trp Phe Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Leu 
145                 150                 155                 160 


Phe Asp Glu Trp Asn Ser Leu Ala Val Tyr Val Ser Met Asp Asn Thr 
                165                 170                 175     


Val Val Ile Glu Asp Ile Lys Lys Met Cys Arg Val Leu Pro Leu Ser 
            180                 185                 190         


Ala Asp Thr Ala Gly Asp Arg Pro Pro Asp Ser Leu Thr Ala Ser Asn 
        195                 200                 205             


Gln Ser Lys Gly Thr Ser Ala Tyr Cys Ser Ala Trp Lys Pro Leu Leu 
    210                 215                 220                 


Leu Ile Val Pro Leu Arg Leu Gly Ile Asn Gln Ile Asn Pro Val Tyr 
225                 230                 235                 240 


Val Asp Ala Phe Lys Glu Cys Phe Lys Met Pro Gln Ser Leu Gly Ala 
                245                 250                 255     


Leu Gly Gly Lys Pro Asn Asn Ala Tyr Tyr Phe Ile Gly Phe Leu Gly 
            260                 265                 270         


Asp Glu Leu Ile Phe Leu Asp Pro His Thr Thr Gln Thr Phe Val Asp 
        275                 280                 285             


Thr Glu Glu Asn Gly Thr Val Asn Asp Gln Thr Phe His Cys Leu Gln 
    290                 295                 300                 


Ser Pro Gln Arg Met Asn Ile Leu Asn Leu Asp Pro Ser Val Ala Leu 
305                 310                 315                 320 


Gly Phe Phe Cys Lys Glu Glu Lys Asp Phe Asp Asn Trp Cys Ser Leu 
                325                 330                 335     


Val Gln Lys Glu Ile Leu Lys Glu Asn Leu Arg Met Phe Glu Leu Val 
            340                 345                 350         


Gln Lys His Pro Ser His Trp Pro Pro Phe Val Pro Pro Ala Lys Pro 
        355                 360                 365             


Glu Val Thr Thr Thr Gly Ala Glu Phe Ile Asp Ser Thr Glu Gln Leu 
    370                 375                 380                 


Glu Glu Phe Asp Leu Glu Glu Asp Phe Glu Ile Leu Ser Val 
385                 390                 395             


<210> 6306
<211> 566
<212> PRT
<213> Homo sapiens

<400> 6306
Met Asp Leu His Arg Ala Ala Phe Lys Met Glu Asn Ser Ser Tyr Leu 
1               5                   10                  15      


Pro Asn Pro Leu Ala Ser Pro Ala Leu Met Val Leu Ala Ser Thr Ala 
            20                  25                  30          


Glu Ala Ser Arg Asp Ala Ser Ile Pro Cys Gln Gln Pro Arg Pro Phe 
        35                  40                  45              


Gly Val Pro Val Ser Val Asp Lys Asp Val His Ile Pro Phe Thr Asn 
    50                  55                  60                  


Gly Ser Tyr Thr Phe Ala Ser Met Tyr His Arg Gln Gly Gly Val Pro 
65                  70                  75                  80  


Gly Thr Phe Ala Asn Arg Asp Phe Pro Pro Ser Leu Leu His Leu His 
                85                  90                  95      


Pro Gln Phe Ala Pro Pro Asn Leu Asp Cys Thr Pro Ile Ser Met Leu 
            100                 105                 110         


Asn His Ser Gly Val Gly Ala Phe Arg Pro Phe Ala Ser Thr Glu Asp 
        115                 120                 125             


Arg Glu Ser Tyr Gln Ser Ala Phe Thr Pro Ala Lys Arg Leu Lys Asn 
    130                 135                 140                 


Cys His Asp Thr Glu Ser Pro His Leu Arg Phe Ser Asp Ala Asp Gly 
145                 150                 155                 160 


Lys Glu Tyr Asp Phe Gly Thr Gln Leu Pro Ser Ser Ser Pro Gly Ser 
                165                 170                 175     


Leu Lys Val Asp Asp Thr Gly Lys Lys Ile Phe Ala Val Ser Gly Leu 
            180                 185                 190         


Ile Ser Asp Arg Glu Ala Ser Ser Ser Pro Glu Asp Arg Asn Asp Arg 
        195                 200                 205             


Cys Lys Lys Lys Ala Ala Ala Leu Phe Asp Ser Gln Ala Pro Ile Cys 
    210                 215                 220                 


Pro Ile Cys Gln Val Leu Leu Arg Pro Ser Glu Leu Gln Glu His Met 
225                 230                 235                 240 


Glu Gln Glu Leu Glu Gln Leu Ala Gln Leu Pro Ser Ser Lys Asn Ser 
                245                 250                 255     


Leu Leu Lys Asp Ala Met Ala Pro Gly Thr Pro Lys Ser Leu Leu Leu 
            260                 265                 270         


Ser Ala Ser Ile Lys Arg Glu Gly Glu Ser Pro Thr Ala Ser Pro His 
        275                 280                 285             


Ser Ser Ala Thr Asp Asp Leu His His Ser Asp Arg Tyr Gln Thr Phe 
    290                 295                 300                 


Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn Ala Arg Ile Gly 
305                 310                 315                 320 


Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Arg Glu Gly Ser Cys 
                325                 330                 335     


Met Ala Glu Asp Asp Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg 
            340                 345                 350         


Phe Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr 
        355                 360                 365             


Leu Leu Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly 
    370                 375                 380                 


Lys Glu Asn Pro Asp Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp 
385                 390                 395                 400 


Thr Leu Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro 
                405                 410                 415     


Cys Thr Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg 
            420                 425                 430         


Gly Ala Val Leu Asn Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu 
        435                 440                 445             


Phe Ser Lys Trp Ala Ser Asp Glu Met Pro Ser Thr Ser Asn Gly Glu 
    450                 455                 460                 


Ser Ser Lys Gln Glu Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile 
465                 470                 475                 480 


Glu Lys Ile Thr Glu Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys 
                485                 490                 495     


Ala Arg Val Arg Glu Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr 
            500                 505                 510         


Lys Cys Leu Ile Cys Met Asp Ser Tyr Ser Met Pro Leu Thr Ser Ile 
        515                 520                 525             


Gln Cys Trp His Val His Cys Glu Glu Cys Trp Leu Arg Thr Leu Gly 
    530                 535                 540                 


Ala Lys Lys Leu Cys Pro Gln Cys Asn Thr Ile Thr Ala Pro Gly Asp 
545                 550                 555                 560 


Leu Arg Arg Ile Tyr Leu 
                565     


<210> 6307
<211> 309
<212> PRT
<213> Homo sapiens

<400> 6307
Met Pro Arg Ala Arg Ser Gly Arg Arg Ser Arg Gly Ala Gly Gly Arg 
1               5                   10                  15      


Glu Glu Thr Phe Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn 
            20                  25                  30          


Ala Arg Ile Gly Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Val 
        35                  40                  45              


Cys Pro Leu Cys Asn Arg Pro Leu Ala Gly Ser Glu Gln Glu Met Ser 
    50                  55                  60                  


Arg His Val Glu His Cys Leu Ser Lys Arg Glu Gly Ser Cys Met Ala 
65                  70                  75                  80  


Glu Asp Asp Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg Phe Glu 
                85                  90                  95      


Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr Leu Leu 
            100                 105                 110         


Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly Lys Glu 
        115                 120                 125             


Asn Pro Asp Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp Thr Leu 
    130                 135                 140                 


Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro Cys Thr 
145                 150                 155                 160 


Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg Gly Ala 
                165                 170                 175     


Val Leu Asn Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu Phe Ser 
            180                 185                 190         


Lys Trp Ala Ser Asp Ala Glu Met Pro Ser Thr Ser Asn Gly Glu Ser 
        195                 200                 205             


Ser Lys Gln Glu Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile Glu 
    210                 215                 220                 


Lys Ile Thr Glu Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys Ala 
225                 230                 235                 240 


Arg Val Arg Glu Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr Lys 
                245                 250                 255     


Cys Leu Ile Cys Met Asp Ser Tyr Ser Met Pro Leu Thr Ser Ile Gln 
            260                 265                 270         


Cys Trp His Val His Cys Glu Glu Cys Trp Leu Arg Thr Leu Gly Ala 
        275                 280                 285             


Lys Lys Leu Cys Pro Gln Cys Asn Thr Ile Thr Ala Pro Gly Asp Leu 
    290                 295                 300                 


Arg Arg Ile Tyr Leu 
305                 


<210> 6308
<211> 374
<212> PRT
<213> Homo sapiens

<400> 6308
Met Glu Ser Val Leu Ser Lys Tyr Glu Asp Gln Ile Thr Ile Phe Thr 
1               5                   10                  15      


Asp Tyr Leu Glu Glu Tyr Pro Asp Thr Asp Glu Leu Val Trp Ile Leu 
            20                  25                  30          


Gly Lys Gln His Leu Leu Lys Thr Gly Gly Thr Gly Pro Ser Ser Asp 
        35                  40                  45              


Ala Gly Trp Gly Cys Met Leu Arg Cys Gly Gln Met Met Leu Ala Gln 
    50                  55                  60                  


Ala Leu Ile Cys Arg His Leu Gly Arg Asp Trp Ser Trp Glu Lys Gln 
65                  70                  75                  80  


Lys Glu Gln Pro Lys Glu Tyr Gln Arg Ile Leu Gln Cys Phe Leu Asp 
                85                  90                  95      


Arg Lys Asp Cys Cys Tyr Ser Ile His Gln Met Ala Gln Met Gly Val 
            100                 105                 110         


Gly Glu Gly Lys Ser Ile Gly Glu Trp Phe Gly Pro Asn Thr Val Ala 
        115                 120                 125             


Gln Val Leu Lys Lys Leu Ala Leu Phe Asp Glu Trp Asn Ser Leu Ala 
    130                 135                 140                 


Val Tyr Val Ser Met Asp Asn Thr Val Val Ile Glu Asp Ile Lys Lys 
145                 150                 155                 160 


Met Cys Arg Val Leu Pro Leu Ser Ala Asp Thr Ala Gly Asp Arg Pro 
                165                 170                 175     


Pro Asp Ser Leu Thr Ala Ser Asn Gln Ser Lys Gly Thr Ser Ala Tyr 
            180                 185                 190         


Cys Ser Ala Trp Lys Pro Leu Leu Leu Ile Val Pro Leu Arg Leu Gly 
        195                 200                 205             


Ile Asn Gln Ile Asn Pro Val Tyr Val Asp Ala Phe Lys Glu Cys Phe 
    210                 215                 220                 


Lys Met Pro Gln Ser Leu Gly Ala Leu Gly Gly Lys Pro Asn Asn Ala 
225                 230                 235                 240 


Tyr Tyr Phe Ile Gly Phe Leu Gly Asp Glu Leu Ile Phe Leu Asp Pro 
                245                 250                 255     


His Thr Thr Gln Thr Phe Val Asp Thr Glu Glu Asn Gly Thr Val Asn 
            260                 265                 270         


Asp Gln Thr Phe His Cys Leu Gln Ser Pro Gln Arg Met Asn Ile Leu 
        275                 280                 285             


Asn Leu Asp Pro Ser Val Ala Leu Gly Phe Phe Cys Lys Glu Glu Lys 
    290                 295                 300                 


Asp Phe Asp Asn Trp Cys Ser Leu Val Gln Lys Glu Ile Leu Lys Glu 
305                 310                 315                 320 


Asn Leu Arg Met Phe Glu Leu Val Gln Lys His Pro Ser His Trp Pro 
                325                 330                 335     


Pro Phe Val Pro Pro Ala Lys Pro Glu Val Thr Thr Thr Gly Ala Glu 
            340                 345                 350         


Phe Ile Asp Ser Thr Glu Gln Leu Glu Glu Phe Asp Leu Glu Glu Asp 
        355                 360                 365             


Phe Glu Ile Leu Ser Val 
    370                 


<210> 6309
<211> 185
<212> PRT
<213> Homo sapiens

<400> 6309
Met Glu Gly Cys Val Ser Asn Leu Met Val Cys Asn Leu Ala Tyr Ser 
1               5                   10                  15      


Gly Lys Leu Glu Glu Leu Lys Glu Ser Ile Leu Ala Asp Lys Ser Leu 
            20                  25                  30          


Ala Thr Arg Thr Asp Gln Asp Ser Arg Thr Ala Leu His Trp Ala Cys 
        35                  40                  45              


Ser Ala Gly His Thr Glu Ile Val Glu Phe Leu Leu Gln Leu Gly Val 
    50                  55                  60                  


Pro Val Asn Asp Lys Asp Asp Ala Ala Ser Lys Asn Arg His Glu Ile 
65                  70                  75                  80  


Ala Val Met Leu Leu Glu Gly Gly Ala Asn Pro Asp Ala Lys Asp His 
                85                  90                  95      


Tyr Glu Ala Thr Ala Met His Arg Ala Ala Ala Lys Gly Asn Leu Lys 
            100                 105                 110         


Met Ile His Ile Leu Leu Tyr Tyr Lys Ala Ser Thr Asn Ile Gln Asp 
        115                 120                 125             


Thr Glu Gly Asn Thr Pro Leu His Leu Ala Cys Asp Glu Glu Arg Val 
    130                 135                 140                 


Glu Glu Ala Lys Leu Leu Val Ser Gln Gly Ala Ser Ile Tyr Ile Glu 
145                 150                 155                 160 


Asn Lys Glu Glu Lys Thr Pro Leu Gln Val Ala Lys Gly Gly Leu Gly 
                165                 170                 175     


Leu Ile Leu Lys Arg Met Val Glu Gly 
            180                 185 


<210> 6310
<211> 110
<212> PRT
<213> Homo sapiens

<400> 6310
Met Glu Gly Cys Val Ser Asn Leu Met Val Cys Asn Leu Ala Tyr Ser 
1               5                   10                  15      


Gly Lys Leu Glu Glu Leu Lys Glu Ser Ile Leu Ala Asp Lys Ser Leu 
            20                  25                  30          


Ala Thr Arg Thr Asp Gln Asp Ser Arg Thr Ala Leu His Trp Ala Cys 
        35                  40                  45              


Ser Ala Gly His Thr Glu Ile Val Glu Phe Leu Leu Gln Leu Gly Val 
    50                  55                  60                  


Pro Val Asn Asp Lys Asp Asp Ala Ala Ser Lys Asn Arg His Glu Ile 
65                  70                  75                  80  


Ala Val Met Leu Leu Glu Gly Gly Ala Asn Pro Asp Ala Lys Asp His 
                85                  90                  95      


Tyr Glu Ala Thr Ala Met His Arg Ala Ala Ala Lys Asp Thr 
            100                 105                 110 


<210> 6311
<211> 181
<212> PRT
<213> Homo sapiens

<400> 6311
Met Val Leu Gly Ala Gly Trp Gly Trp Ala Tyr Gln Leu His Leu Leu 
1               5                   10                  15      


Gln Ala Leu Lys Arg Lys Pro Asp Leu Phe Leu Cys Glu Arg Leu Asp 
            20                  25                  30          


Val Lys Ala Val Phe Gln Cys Ala Val Leu Ala Leu Lys Phe Pro Glu 
        35                  40                  45              


Ala Pro Thr Val Lys Ala Ser Cys Gly Phe Phe Thr Glu Leu Leu Pro 
    50                  55                  60                  


Arg Cys Gly Glu Val Glu Ser Val Gly Lys Val Val Gln Glu Asp Gly 
65                  70                  75                  80  


Arg Met Leu Leu Ile Ala Val Leu Glu Ala Ile Gly Gly Gln Ala Ser 
                85                  90                  95      


Arg Ser Leu Met Asp Cys Phe Ala Asp Ile Leu Phe Ala Leu Asn Lys 
            100                 105                 110         


His Cys Phe Ser Leu Leu Ser Met Trp Ile Lys Glu Ala Leu Gln Pro 
        115                 120                 125             


Pro Gly Phe Pro Ser Ala Arg Leu Ser Pro Glu Gln Lys Asp Thr Phe 
    130                 135                 140                 


Ser Gln Gln Ile Leu Arg Glu Arg Val Asn Lys Arg Arg Val Lys Glu 
145                 150                 155                 160 


Met Val Lys Glu Phe Thr Leu Leu Cys Arg Gly Leu His Gly Thr Asp 
                165                 170                 175     


Tyr Thr Ala Asp Tyr 
            180     


<210> 6312
<211> 963
<212> PRT
<213> Homo sapiens

<400> 6312
Met Glu Arg Arg Glu Glu Gln Pro Gly Ala Ala Gly Ala Gly Ala Ala 
1               5                   10                  15      


Pro Ala Leu Asp Phe Thr Val Glu Asn Val Glu Lys Ala Leu His Gln 
            20                  25                  30          


Leu Tyr Tyr Asp Pro Asn Ile Glu Asn Lys Asn Leu Ala Gln Lys Trp 
        35                  40                  45              


Leu Met Gln Ala Gln Val Ser Pro Gln Ala Trp His Phe Ser Trp Gln 
    50                  55                  60                  


Leu Leu Gln Pro Asp Lys Val Pro Glu Ile Gln Tyr Phe Gly Ala Ser 
65                  70                  75                  80  


Ala Leu His Ile Lys Ile Ser Arg Tyr Trp Ser Asp Ile Pro Thr Asp 
                85                  90                  95      


Gln Tyr Glu Ser Leu Lys Ala Gln Leu Phe Thr Gln Ile Thr Arg Phe 
            100                 105                 110         


Ala Ser Gly Ser Lys Ile Val Leu Thr Arg Leu Cys Val Ala Leu Ala 
        115                 120                 125             


Ser Leu Ala Leu Ser Met Met Pro Asp Ala Trp Pro Cys Ala Val Ala 
    130                 135                 140                 


Asp Met Val Arg Leu Phe Gln Ala Glu Asp Ser Pro Val Asp Gly Gln 
145                 150                 155                 160 


Gly Arg Cys Leu Ala Leu Leu Glu Leu Leu Thr Val Leu Pro Glu Glu 
                165                 170                 175     


Phe Gln Thr Ser Arg Leu Pro Gln Tyr Arg Lys Gly Leu Val Arg Thr 
            180                 185                 190         


Ser Leu Ala Val Glu Cys Gly Ala Val Phe Pro Leu Leu Glu Gln Leu 
        195                 200                 205             


Leu Gln Gln Pro Ser Ser Pro Ser Cys Val Arg Gln Lys Val Leu Lys 
    210                 215                 220                 


Cys Phe Ser Ser Trp Val Gln Leu Glu Val Pro Leu Gln Asp Cys Glu 
225                 230                 235                 240 


Ala Leu Ile Gln Ala Ala Phe Ala Ala Leu Gln Asp Ser Glu Leu Phe 
                245                 250                 255     


Asp Ser Ser Val Glu Ala Ile Val Asn Ala Ile Ser Gln Pro Asp Ala 
            260                 265                 270         


Gln Arg Tyr Val Asn Thr Leu Leu Lys Leu Ile Pro Leu Val Leu Gly 
        275                 280                 285             


Leu Gln Glu Gln Leu Arg Gln Ala Val Gln Asn Gly Asp Met Glu Thr 
    290                 295                 300                 


Ser His Gly Ile Cys Arg Ile Ala Val Ala Leu Gly Glu Asn His Ser 
305                 310                 315                 320 


Arg Ala Leu Leu Asp Gln Val Glu His Trp Gln Ser Phe Leu Ala Leu 
                325                 330                 335     


Val Asn Met Ile Met Phe Cys Thr Gly Ile Pro Gly His Tyr Pro Val 
            340                 345                 350         


Asn Glu Thr Thr Ser Ser Leu Thr Leu Thr Phe Trp Tyr Thr Leu Gln 
        355                 360                 365             


Asp Asp Ile Leu Ser Phe Glu Ala Glu Lys Gln Ala Val Tyr Gln Gln 
    370                 375                 380                 


Val Tyr Arg Pro Val Tyr Phe Gln Leu Val Asp Val Leu Leu His Lys 
385                 390                 395                 400 


Ala Gln Phe Pro Ser Asp Glu Glu Tyr Gly Phe Trp Ser Ser Asp Glu 
                405                 410                 415     


Lys Glu Gln Phe Arg Ile Tyr Arg Val Asp Ile Ser Asp Thr Leu Met 
            420                 425                 430         


Tyr Val Tyr Glu Met Leu Gly Ala Glu Leu Leu Ser Asn Leu Tyr Asp 
        435                 440                 445             


Lys Leu Gly Arg Leu Leu Thr Ser Ser Glu Glu Pro Tyr Ser Trp Gln 
    450                 455                 460                 


His Thr Glu Ala Leu Leu Tyr Gly Phe Gln Ser Ile Ala Glu Thr Ile 
465                 470                 475                 480 


Asp Val Asn Tyr Ser Asp Val Val Pro Gly Leu Ile Gly Leu Ile Pro 
                485                 490                 495     


Arg Ile Ser Ile Ser Asn Val Gln Leu Ala Asp Thr Val Met Phe Thr 
            500                 505                 510         


Ile Gly Ala Leu Ser Glu Trp Leu Ala Asp His Pro Val Met Ile Asn 
        515                 520                 525             


Ser Val Leu Pro Leu Val Leu His Ala Leu Gly Asn Pro Glu Leu Ser 
    530                 535                 540                 


Val Ser Ser Val Ser Thr Leu Lys Lys Ile Cys Arg Glu Cys Lys Tyr 
545                 550                 555                 560 


Asp Leu Pro Pro Tyr Ala Ala Asn Ile Val Ala Val Ser Gln Asp Val 
                565                 570                 575     


Leu Met Lys Gln Ile His Lys Thr Ser Gln Cys Met Trp Leu Met Gln 
            580                 585                 590         


Ala Leu Gly Phe Leu Leu Ser Ala Leu Gln Val Glu Glu Ile Leu Lys 
        595                 600                 605             


Asn Leu His Ser Leu Ile Ser Pro Tyr Ile Gln Gln Leu Glu Lys Leu 
    610                 615                 620                 


Ala Glu Glu Ile Pro Asn Pro Ser Asn Lys Leu Ala Ile Val His Ile 
625                 630                 635                 640 


Leu Gly Leu Leu Ser Asn Leu Phe Thr Thr Leu Asp Ile Ser His His 
                645                 650                 655     


Glu Asp Asp His Glu Gly Pro Glu Leu Arg Lys Leu Pro Val Pro Gln 
            660                 665                 670         


Gly Pro Asn Pro Val Val Val Val Leu Gln Gln Val Phe Gln Leu Ile 
        675                 680                 685             


Gln Lys Val Leu Ser Lys Trp Leu Asn Asp Ala Gln Val Val Glu Ala 
    690                 695                 700                 


Val Cys Ala Ile Phe Glu Lys Ser Val Lys Thr Leu Leu Asp Asp Phe 
705                 710                 715                 720 


Ala Pro Met Val Pro Gln Leu Cys Glu Met Leu Gly Arg Met Tyr Ser 
                725                 730                 735     


Thr Ile Pro Gln Ala Ser Ala Leu Asp Leu Thr Arg Gln Leu Val His 
            740                 745                 750         


Ile Phe Ala His Glu Pro Ala His Phe Pro Pro Ile Glu Ala Leu Phe 
        755                 760                 765             


Leu Leu Val Thr Ser Val Thr Leu Thr Leu Phe Gln Gln Gly Pro Arg 
    770                 775                 780                 


Asp His Pro Asp Ile Val Asp Ser Phe Met Gln Leu Leu Ala Gln Ala 
785                 790                 795                 800 


Leu Lys Arg Lys Pro Asp Leu Phe Leu Cys Glu Arg Leu Asp Val Lys 
                805                 810                 815     


Ala Val Phe Gln Cys Ala Val Leu Ala Leu Lys Phe Pro Glu Ala Pro 
            820                 825                 830         


Thr Val Lys Ala Ser Cys Gly Phe Phe Thr Glu Leu Leu Pro Arg Cys 
        835                 840                 845             


Gly Glu Val Glu Ser Val Gly Lys Val Val Gln Glu Asp Gly Arg Met 
    850                 855                 860                 


Leu Leu Ile Ala Val Leu Glu Ala Ile Gly Gly Gln Ala Ser Arg Ser 
865                 870                 875                 880 


Leu Met Asp Cys Phe Ala Asp Ile Leu Phe Ala Leu Asn Lys His Cys 
                885                 890                 895     


Phe Ser Leu Leu Ser Met Trp Ile Lys Glu Ala Leu Gln Pro Pro Gly 
            900                 905                 910         


Phe Pro Ser Ala Arg Leu Ser Pro Glu Gln Lys Asp Thr Phe Ser Gln 
        915                 920                 925             


Gln Ile Leu Arg Glu Arg Val Asn Lys Arg Arg Val Lys Glu Met Val 
    930                 935                 940                 


Lys Glu Phe Thr Leu Leu Cys Arg Gly Leu His Gly Thr Asp Tyr Thr 
945                 950                 955                 960 


Ala Asp Tyr 
            


<210> 6313
<211> 968
<212> PRT
<213> Homo sapiens

<400> 6313
Met Arg Leu Leu Arg His Thr Glu Ser Glu Gln Trp Phe His Arg Phe 
1               5                   10                  15      


Pro Leu Cys Pro Ser Leu Thr Phe Trp Ala Pro Val Ala Met Trp Pro 
            20                  25                  30          


Gln Thr His Cys Val Gly Gly Arg Ser Ser Gly Leu Thr Lys Trp Thr 
        35                  40                  45              


Tyr Ser Phe Ser Ala Ser Leu Gln Asp Gly Ser Phe Pro Tyr Asp Ser 
    50                  55                  60                  


Val Pro Trp Gln Gln Asn Thr Asn Gln Pro Pro Gly Ser Leu Ser Val 
65                  70                  75                  80  


Val Thr Thr Val Trp Gly Val Thr Asn Thr Ser Gln Ser Gln Ala Asp 
                85                  90                  95      


Val Leu Ile Pro His Ala Thr Cys Arg Pro Gly Pro Leu Leu Ile Thr 
            100                 105                 110         


Ala Trp Glu Pro Tyr Gly Gln Cys Gln Gln Pro His Glu Ser Arg Arg 
        115                 120                 125             


Gln Pro His Gly Val Gly His Asp His Gln Gln Pro Arg Pro Gln Leu 
    130                 135                 140                 


Pro Thr Val Cys Gly Ala Ala Ala Ala Val Leu Ser Gln Gly Trp Pro 
145                 150                 155                 160 


Arg Ser Ala Leu His Pro Ala Glu His Val Trp Pro Ala Gln Leu Pro 
                165                 170                 175     


Arg Gln Arg Gly Leu Trp Gly Gln Pro Ala Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Val Ala Ala Ala Ala Ala Thr Ala Thr Ala Thr Ala Thr Ala Thr 
        195                 200                 205             


Val Ala Ala Leu Gln Glu Thr Gln Asn Lys Asp Ile Asn Gln Tyr Gly 
    210                 215                 220                 


Pro Ala Pro Val Leu Leu Pro Asp Leu Leu Lys Asp Gly Leu Gly Asp 
225                 230                 235                 240 


Glu Glu Arg Gly Ala Pro Ile Gly Met Gln Asn Ser Met Asn Pro Ala 
                245                 250                 255     


Ser Met Ala Ala Gly Met Thr Pro Ser Gly Met Ser Gly Pro Pro Met 
            260                 265                 270         


Gly Met Asn Gln Pro Arg Pro Pro Gly Ile Ser Pro Phe Gly Thr His 
        275                 280                 285             


Gly Gln Arg Met Pro Gln Gln Thr Tyr Pro Gly Pro Arg Pro Gln Ser 
    290                 295                 300                 


Leu Pro Ile Gln Asn Ile Lys Arg Pro Tyr Pro Gly Glu Pro Asn Tyr 
305                 310                 315                 320 


Gly Asn Gln Gln Tyr Gly Pro Asn Ser Gln Phe Pro Thr Gln Pro Gly 
                325                 330                 335     


Gln Tyr Pro Ala Pro Asn Pro Pro Arg Pro Leu Thr Ser Pro Asn Tyr 
            340                 345                 350         


Pro Gly Gln Arg Met Pro Ser Gln Pro Ser Ser Gly Gln Tyr Pro Pro 
        355                 360                 365             


Pro Thr Val Asn Met Gly Gln Tyr Tyr Lys Pro Glu Gln Phe Asn Gly 
    370                 375                 380                 


Gln Asn Asn Thr Phe Ser Gly Ser Ser Tyr Ser Asn Tyr Ser Gln Gly 
385                 390                 395                 400 


Asn Val Asn Arg Pro Pro Arg Pro Val Pro Val Ala Asn Tyr Pro His 
                405                 410                 415     


Ser Pro Val Pro Gly Asn Pro Thr Pro Pro Met Thr Pro Gly Ser Ser 
            420                 425                 430         


Ile Pro Pro Tyr Leu Ser Pro Ser Gln Asp Val Lys Pro Pro Phe Pro 
        435                 440                 445             


Pro Asp Ile Lys Pro Asn Met Ser Ala Leu Pro Pro Pro Pro Asp His 
    450                 455                 460                 


Asn Asp Glu Leu Arg Leu Thr Phe Pro Val Arg Asp Gly Val Val Leu 
465                 470                 475                 480 


Glu Pro Phe Arg Leu Glu His Asn Leu Ala Val Ser Asn His Val Phe 
                485                 490                 495     


His Leu Arg Pro Thr Val His Gln Thr Leu Met Trp Ser Asp Leu Glu 
            500                 505                 510         


Leu Gln Phe Lys Cys Tyr His His Glu Asp Arg Gln Met Asn Thr Asn 
        515                 520                 525             


Trp Pro Ala Ser Val Gln Val Ser Val Asn Ala Thr Pro Leu Thr Ile 
    530                 535                 540                 


Glu Arg Gly Asp Asn Lys Thr Ser His Lys Pro Leu His Leu Lys His 
545                 550                 555                 560 


Val Cys Gln Pro Gly Arg Asn Thr Ile Gln Ile Thr Val Thr Ala Cys 
                565                 570                 575     


Cys Cys Ser His Leu Phe Val Leu Gln Leu Val His Arg Pro Ser Val 
            580                 585                 590         


Arg Ser Val Leu Gln Gly Leu Leu Lys Lys Arg Leu Leu Pro Ala Glu 
        595                 600                 605             


His Cys Ile Thr Lys Lys Arg Asn Phe Ser Ser Val Ala Ala Ser Ser 
    610                 615                 620                 


Gly Asn Thr Thr Leu Asn Gly Glu Asp Gly Val Glu Gln Thr Ala Ile 
625                 630                 635                 640 


Lys Val Ser Leu Lys Cys Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro 
                645                 650                 655     


Ala Arg Gly His Asp Cys Lys His Val Gln Cys Phe Asp Leu Glu Ser 
            660                 665                 670         


Tyr Leu Gln Leu Asn Cys Glu Arg Gly Thr Trp Arg Cys Pro Val Cys 
        675                 680                 685             


Lys Thr Ala Leu Leu Glu Gly Leu Glu Val Asp Gln Tyr Met Trp Gly 
    690                 695                 700                 


Ile Leu Asn Ala Ile His Ser Glu Phe Glu Glu Val Thr Ile Asp Pro 
705                 710                 715                 720 


Thr Cys Ser Trp Arg Pro Val Pro Ile Lys Ser Asp Leu His Ile Lys 
                725                 730                 735     


Asp Asp Pro Asp Gly Ile Pro Ser Lys Arg Phe Lys Thr Met Ser Pro 
            740                 745                 750         


Ser Gln Met Ile Met Pro Asn Val Met Glu Met Ile Ala Ala Leu Gly 
        755                 760                 765             


Pro Gly Pro Ser Pro Tyr Pro Leu Pro Pro Pro Pro Gly Gly Thr Asn 
    770                 775                 780                 


Ser Asn Asp Tyr Ser Ser Gln Asn Asn Tyr Gln Gly His Gly Asn Phe 
785                 790                 795                 800 


Asp Phe Pro His Gly Asn Pro Gly Gly Thr Ser Met Asn Asp Phe Met 
                805                 810                 815     


His Gly Pro Pro Gln Leu Ser His Pro Pro Asp Met Pro Asn Asn Met 
            820                 825                 830         


Ala Ala Leu Glu Lys Pro Leu Ser His Pro Met Gln Glu Thr Met Pro 
        835                 840                 845             


His Ala Gly Ser Ser Asp Gln Pro His Pro Ser Ile Gln Gln Gly Leu 
    850                 855                 860                 


His Val Pro His Pro Ser Ser Gln Ser Gly Pro Pro Leu His His Ser 
865                 870                 875                 880 


Gly Ala Pro Pro Pro Pro Pro Ser Gln Pro Pro Arg Gln Pro Pro Gln 
                885                 890                 895     


Ala Ala Pro Ser Ser His Pro His Ser Asp Leu Thr Phe Asn Pro Ser 
            900                 905                 910         


Ser Ala Leu Glu Gly Gln Ala Gly Ala Gln Gly Ala Ser Asp Met Pro 
        915                 920                 925             


Glu Pro Ser Leu Asp Leu Leu Pro Glu Leu Thr Asn Pro Asp Glu Leu 
    930                 935                 940                 


Leu Ser Tyr Leu Asp Pro Pro Asp Leu Pro Ser Asn Ser Asn Asp Asp 
945                 950                 955                 960 


Leu Leu Ser Leu Phe Glu Asn Asn 
                965             


<210> 6314
<211> 200
<212> PRT
<213> Homo sapiens

<400> 6314
Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Ala Glu 
    130                 135                 140                 


Val Gln Ala Val Phe Ser Asp Gly Ala Val Ser Leu His Thr Arg Ser 
145                 150                 155                 160 


Leu Lys Tyr Gly Lys Thr His Phe His Asp Leu Pro Cys Gly Ala Ser 
                165                 170                 175     


Val Ile Leu Gly Asn Asn Gly Phe Ile Trp Ile Tyr Pro Thr Pro Glu 
            180                 185                 190         


His Lys Glu Glu Glu Ala Gly Gly 
        195                 200 


<210> 6315
<211> 263
<212> PRT
<213> Homo sapiens

<400> 6315
Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Arg Arg Arg Ser Ala Glu 
                85                  90                  95      


Asp Glu Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser 
            100                 105                 110         


Ala Glu Val Gln Ala Val Phe Ser Asp Gly Ala Val Ser Leu His Thr 
        115                 120                 125             


Arg Ser Leu Lys Tyr Gly Lys Leu Gly Gln Gly Val Leu Val Gln Val 
    130                 135                 140                 


Ser Pro Ser Leu Val Lys Arg Gln Lys Thr His Phe His Asp Leu Pro 
145                 150                 155                 160 


Cys Gly Ala Ser Val Ile Leu Gly Asn Asn Gly Phe Ile Trp Ile Tyr 
                165                 170                 175     


Pro Thr Pro Glu His Lys Glu Glu Glu Ala Gly Gly Phe Ile Ala Asn 
            180                 185                 190         


Leu Glu Pro Val Ser Leu Ala Asp Arg Glu Val Ile Ser Arg Leu Arg 
        195                 200                 205             


Asn Cys Ile Ile Ser Leu Val Thr Gln Arg Met Met Leu Tyr Asp Thr 
    210                 215                 220                 


Ser Ile Leu Tyr Cys Tyr Glu Ala Ser Leu Pro His Gln Ile Lys Asp 
225                 230                 235                 240 


Ile Leu Lys Pro Glu Ile Met Glu Glu Ile Val Met Glu Thr Arg Gln 
                245                 250                 255     


Arg Leu Leu Glu Gln Glu Gly 
            260             


<210> 6316
<211> 285
<212> PRT
<213> Homo sapiens

<400> 6316
Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Ala Glu 
    130                 135                 140                 


Val Gln Ala Val Phe Ser Asp Gly Ala Val Ser Leu His Thr Arg Ser 
145                 150                 155                 160 


Leu Lys Tyr Gly Lys Val Ser Pro Ser Leu Val Lys Arg Gln Lys Thr 
                165                 170                 175     


His Phe His Asp Leu Pro Cys Gly Ala Ser Val Ile Leu Gly Asn Asn 
            180                 185                 190         


Gly Phe Ile Trp Ile Tyr Pro Thr Pro Glu His Lys Glu Glu Glu Ala 
        195                 200                 205             


Gly Gly Phe Ile Ala Asn Leu Glu Pro Val Ser Leu Ala Asp Arg Glu 
    210                 215                 220                 


Val Ile Ser Arg Leu Arg Asn Cys Ile Ile Ser Leu Val Thr Gln Arg 
225                 230                 235                 240 


Met Met Leu Tyr Asp Thr Ser Ile Leu Tyr Cys Tyr Glu Ala Ser Leu 
                245                 250                 255     


Pro His Gln Ile Lys Asp Ile Leu Lys Pro Glu Ile Met Glu Glu Ile 
            260                 265                 270         


Val Met Glu Thr Arg Gln Arg Leu Leu Glu Gln Glu Gly 
        275                 280                 285 


<210> 6317
<211> 293
<212> PRT
<213> Homo sapiens

<400> 6317
Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Ala Glu 
    130                 135                 140                 


Val Gln Ala Val Phe Ser Asp Gly Ala Val Ser Leu His Thr Arg Ser 
145                 150                 155                 160 


Leu Lys Tyr Gly Lys Leu Gly Gln Gly Val Leu Val Gln Val Ser Pro 
                165                 170                 175     


Ser Leu Val Lys Arg Gln Lys Thr His Phe His Asp Leu Pro Cys Gly 
            180                 185                 190         


Ala Ser Val Ile Leu Gly Asn Asn Gly Phe Ile Trp Ile Tyr Pro Thr 
        195                 200                 205             


Pro Glu His Lys Glu Glu Glu Ala Gly Gly Phe Ile Ala Asn Leu Glu 
    210                 215                 220                 


Pro Val Ser Leu Ala Asp Arg Glu Val Ile Ser Arg Leu Arg Asn Cys 
225                 230                 235                 240 


Ile Ile Ser Leu Val Thr Gln Arg Met Met Leu Tyr Asp Thr Ser Ile 
                245                 250                 255     


Leu Tyr Cys Tyr Glu Ala Ser Leu Pro His Gln Ile Lys Asp Ile Leu 
            260                 265                 270         


Lys Pro Glu Ile Met Glu Glu Ile Val Met Glu Thr Arg Gln Arg Leu 
        275                 280                 285             


Leu Glu Gln Glu Gly 
    290             


<210> 6318
<211> 1064
<212> PRT
<213> Homo sapiens

<400> 6318
Met Ala Ser Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr 
1               5                   10                  15      


Phe Tyr Pro Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala 
            20                  25                  30          


Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val 
        35                  40                  45              


Pro Pro Lys Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp 
    50                  55                  60                  


Leu Val Ile Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly 
65                  70                  75                  80  


Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu 
                85                  90                  95      


Phe Arg Lys Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser 
            100                 105                 110         


Glu Phe Glu Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn 
        115                 120                 125             


Pro Pro Ile Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His 
    130                 135                 140                 


Val Asp Glu Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val 
145                 150                 155                 160 


Glu Lys Glu Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu 
                165                 170                 175     


Tyr Phe Gly Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met 
            180                 185                 190         


Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp 
        195                 200                 205             


Tyr Ser Val Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys 
    210                 215                 220                 


Gly Phe Phe Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His 
225                 230                 235                 240 


Lys Met Thr Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro 
                245                 250                 255     


Phe Asp Lys Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro 
            260                 265                 270         


Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser 
        275                 280                 285             


Thr Asn Phe Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val 
    290                 295                 300                 


Leu Cys Ser Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe 
305                 310                 315                 320 


Val Arg Lys Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys 
                325                 330                 335     


Asp Asn Thr Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala Ala Glu 
            340                 345                 350         


Phe Leu Lys Glu Ser Glu Leu Pro Pro Arg Ala Gly Asn Glu Glu Glu 
        355                 360                 365             


Cys Pro Glu Glu Asp Met Glu Gly Val Glu Asp Gly Glu Glu Gly Asp 
    370                 375                 380                 


Leu Lys Thr Ser Leu Ala Lys His Arg Ile Gly Thr Lys Arg His Arg 
385                 390                 395                 400 


Val Cys Leu Glu Ile Pro Gln Glu Val Ser Gln Ser Glu Leu Phe Pro 
                405                 410                 415     


Lys Glu Asp Leu Ser Ser Glu Gln Tyr Glu Met Thr Glu Cys Pro Ala 
            420                 425                 430         


Ala Leu Ala Pro Val Arg Pro Thr His Ser Ser Val Arg Gln Val Glu 
        435                 440                 445             


Asp Gly Leu Thr Phe Pro Asp Tyr Ser Asp Ser Thr Glu Val Lys Phe 
    450                 455                 460                 


Glu Glu Leu Lys Asn Val Lys Leu Glu Glu Glu Asp Glu Glu Glu Glu 
465                 470                 475                 480 


Gln Ala Ala Ala Ala Leu Asp Leu Ser Val Asn Pro Ala Ser Val Gly 
                485                 490                 495     


Gly Arg Leu Val Phe Ser Gly Ser Lys Lys Lys Ser Ser Ser Ser Leu 
            500                 505                 510         


Gly Ser Gly Ser Ser Arg Asp Ser Ile Ser Ser Asp Ser Glu Thr Ser 
        515                 520                 525             


Glu Pro Leu Ser Cys Arg Ala Gln Gly Gln Thr Gly Val Leu Thr Val 
    530                 535                 540                 


His Ser Tyr Ala Lys Gly Asp Gly Arg Val Thr Val Gly Glu Pro Cys 
545                 550                 555                 560 


Thr Arg Lys Lys Gly Ser Ala Ala Arg Ser Phe Ser Glu Arg Glu Leu 
                565                 570                 575     


Ala Glu Val Ala Asp Glu Tyr Met Phe Ser Leu Glu Glu Asn Lys Lys 
            580                 585                 590         


Ser Lys Gly Arg Arg Gln Pro Leu Ser Lys Leu Pro Arg His His Pro 
        595                 600                 605             


Leu Val Leu Gln Glu Cys Val Ser Asp Asp Glu Thr Ser Glu Gln Leu 
    610                 615                 620                 


Thr Pro Glu Glu Glu Ala Glu Glu Thr Glu Ala Trp Ala Lys Pro Leu 
625                 630                 635                 640 


Ser Gln Leu Trp Gln Asn Arg Pro Pro Asn Phe Glu Ala Glu Lys Glu 
                645                 650                 655     


Phe Asn Glu Thr Met Ala Gln Gln Ala Pro His Cys Ala Val Cys Met 
            660                 665                 670         


Ile Phe Gln Thr Tyr His Gln Val Glu Phe Gly Gly Phe Asn Gln Asn 
        675                 680                 685             


Cys Gly Asn Ala Ser Asp Leu Ala Pro Gln Lys Gln Arg Thr Lys Pro 
    690                 695                 700                 


Leu Ile Pro Glu Met Cys Phe Thr Ser Thr Gly Cys Ser Thr Asp Ile 
705                 710                 715                 720 


Asn Leu Ser Thr Pro Tyr Leu Glu Glu Asp Gly Thr Ser Ile Leu Val 
                725                 730                 735     


Ser Cys Lys Lys Cys Ser Val Arg Val His Ala Ser Cys Tyr Gly Val 
            740                 745                 750         


Pro Pro Ala Lys Ala Ser Glu Asp Trp Met Cys Ser Arg Cys Ser Ala 
        755                 760                 765             


Asn Ala Leu Glu Glu Asp Cys Cys Leu Cys Ser Leu Arg Gly Gly Ala 
    770                 775                 780                 


Leu Gln Arg Ala Asn Asp Asp Arg Trp Val His Val Ser Cys Ala Val 
785                 790                 795                 800 


Ala Ile Leu Glu Ala Arg Phe Val Asn Ile Ala Glu Arg Ser Pro Val 
                805                 810                 815     


Asp Val Ser Lys Ile Pro Leu Pro Arg Phe Lys Leu Lys Cys Ile Phe 
            820                 825                 830         


Cys Lys Lys Arg Arg Lys Arg Thr Ala Gly Cys Cys Val Gln Cys Ser 
        835                 840                 845             


His Gly Arg Cys Pro Thr Ala Phe His Val Ser Cys Ala Gln Ala Ala 
    850                 855                 860                 


Gly Val Met Met Gln Pro Asp Asp Trp Pro Phe Val Val Phe Ile Thr 
865                 870                 875                 880 


Cys Phe Arg His Lys Ile Pro Asn Leu Glu Arg Ala Lys Gly Ala Leu 
                885                 890                 895     


Gln Ser Ile Thr Ala Gly Gln Lys Val Ile Ser Lys His Lys Asn Gly 
            900                 905                 910         


Arg Phe Tyr Gln Cys Glu Val Val Arg Leu Thr Thr Glu Thr Phe Tyr 
        915                 920                 925             


Glu Val Asn Phe Asp Asp Gly Ser Phe Ser Asp Asn Leu Tyr Pro Glu 
    930                 935                 940                 


Asp Ile Val Ser Gln Asp Cys Leu Gln Phe Gly Pro Pro Ala Glu Gly 
945                 950                 955                 960 


Glu Val Val Gln Val Arg Trp Thr Asp Gly Gln Val Tyr Gly Ala Lys 
                965                 970                 975     


Phe Val Ala Ser His Pro Ile Gln Met Tyr Gln Val Glu Phe Glu Asp 
            980                 985                 990         


Gly Ser Gln Leu Val Val Lys Arg  Asp Asp Val Tyr Thr  Leu Asp Glu 
        995                 1000                 1005             


Glu Leu  Pro Lys Arg Val Lys  Ser Arg Leu Ser Val  Ala Ser Asp 
    1010                 1015                 1020             


Met Arg  Phe Asn Glu Ile Phe  Thr Glu Lys Glu Val  Lys Gln Glu 
    1025                 1030                 1035             


Lys Lys  Arg Gln Arg Val Ile  Asn Ser Arg Tyr Arg  Glu Asp Tyr 
    1040                 1045                 1050             


Ile Glu  Pro Ala Leu Tyr Arg  Ala Ile Met Glu 
    1055                 1060                 


<210> 6319
<211> 914
<212> PRT
<213> Homo sapiens

<400> 6319
Met Gly Asp Ser Arg Asp Leu Cys Pro His Leu Asp Ser Ile Gly Glu 
1               5                   10                  15      


Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Gly Thr Cys Gln Ser 
            20                  25                  30          


Cys Gly Val Thr Gly Pro Asn Leu Trp Ala Cys Leu Gln Val Ala Cys 
        35                  40                  45              


Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His 
    50                  55                  60                  


Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg 
65                  70                  75                  80  


Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu 
                85                  90                  95      


Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser 
            100                 105                 110         


Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp 
        115                 120                 125             


Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu 
    130                 135                 140                 


Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu 
145                 150                 155                 160 


Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe Phe Leu Glu Cys 
                165                 170                 175     


Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr 
            180                 185                 190         


Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val 
        195                 200                 205             


Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe 
    210                 215                 220                 


Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met 
225                 230                 235                 240 


Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala 
                245                 250                 255     


Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg 
            260                 265                 270         


Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser 
        275                 280                 285             


Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser 
    290                 295                 300                 


Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala 
305                 310                 315                 320 


Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln 
                325                 330                 335     


Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr 
            340                 345                 350         


Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser 
        355                 360                 365             


Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala 
    370                 375                 380                 


His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu 
385                 390                 395                 400 


Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg 
                405                 410                 415     


Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly 
            420                 425                 430         


Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile 
        435                 440                 445             


Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg 
    450                 455                 460                 


Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro 
465                 470                 475                 480 


Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val 
                485                 490                 495     


Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp 
            500                 505                 510         


Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr 
        515                 520                 525             


Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala 
    530                 535                 540                 


Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys 
545                 550                 555                 560 


Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu 
                565                 570                 575     


Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu 
            580                 585                 590         


Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu 
        595                 600                 605             


Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile 
    610                 615                 620                 


Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly 
625                 630                 635                 640 


Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp 
                645                 650                 655     


Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val 
            660                 665                 670         


Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu 
        675                 680                 685             


Ala Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu 
    690                 695                 700                 


Pro Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe 
705                 710                 715                 720 


Asn Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys 
                725                 730                 735     


Ser His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu 
            740                 745                 750         


Val Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe 
        755                 760                 765             


Gly Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln 
    770                 775                 780                 


Val Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr 
785                 790                 795                 800 


Phe Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val 
                805                 810                 815     


Ile Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val 
            820                 825                 830         


Lys Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile 
        835                 840                 845             


Ala Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp 
    850                 855                 860                 


Tyr Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr 
865                 870                 875                 880 


Gly Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu 
                885                 890                 895     


Gly Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg 
            900                 905                 910         


Ala Val 
        


<210> 6320
<211> 404
<212> PRT
<213> Homo sapiens

<400> 6320
Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Cys Glu Gly Asp Thr 
            180                 185                 190         


Val Pro Asp Phe Gln Glu Thr Arg Pro Arg Asn Tyr Ile Leu Ser Ala 
        195                 200                 205             


Ser Ala Ser Ala Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gln Glu 
    210                 215                 220                 


Leu Arg Val Ala Gln Thr Glu Phe Asp Arg Gln Ala Glu Val Thr Arg 
225                 230                 235                 240 


Leu Leu Leu Glu Gly Ile Ser Ser Thr His Val Asn His Leu Arg Cys 
                245                 250                 255     


Leu His Glu Phe Val Lys Ser Gln Thr Thr Tyr Tyr Ala Gln Cys Tyr 
            260                 265                 270         


Arg His Met Leu Asp Leu Gln Lys Gln Leu Gly Ser Ser Gln Gly Ala 
        275                 280                 285             


Ile Phe Pro Gly Thr Phe Val Gly Thr Thr Glu Pro Ala Ser Pro Pro 
    290                 295                 300                 


Leu Ser Ser Thr Ser Pro Thr Thr Ala Ala Ala Thr Met Pro Val Val 
305                 310                 315                 320 


Pro Ser Val Ala Ser Leu Ala Pro Pro Gly Glu Ala Ser Leu Cys Leu 
                325                 330                 335     


Glu Glu Val Ala Pro Pro Ala Ser Gly Thr Arg Lys Ala Arg Val Leu 
            340                 345                 350         


Tyr Asp Tyr Glu Ala Ala Asp Ser Ser Glu Leu Ala Leu Leu Ala Asp 
        355                 360                 365             


Glu Leu Ile Thr Val Tyr Ser Leu Pro Gly Met Asp Pro Asp Trp Leu 
    370                 375                 380                 


Ile Gly Glu Arg Gly Asn Lys Lys Gly Lys Val Pro Val Thr Tyr Leu 
385                 390                 395                 400 


Glu Leu Leu Ser 
                


<210> 6321
<211> 395
<212> PRT
<213> Homo sapiens

<400> 6321
Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Thr Val Pro Asp Phe 
            180                 185                 190         


Gln Glu Thr Arg Pro Arg Asn Tyr Ile Leu Ser Ala Ser Ala Ser Ala 
        195                 200                 205             


Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gln Glu Leu Arg Val Ala 
    210                 215                 220                 


Gln Thr Glu Phe Asp Arg Gln Ala Glu Val Thr Arg Leu Leu Leu Glu 
225                 230                 235                 240 


Gly Ile Ser Ser Thr His Val Asn His Leu Arg Cys Leu His Glu Phe 
                245                 250                 255     


Val Lys Ser Gln Thr Thr Tyr Tyr Ala Gln Cys Tyr Arg His Met Leu 
            260                 265                 270         


Asp Leu Gln Lys Gln Leu Gly Arg Phe Pro Gly Thr Phe Val Gly Thr 
        275                 280                 285             


Thr Glu Pro Ala Ser Pro Pro Leu Ser Ser Thr Ser Pro Thr Thr Ala 
    290                 295                 300                 


Ala Ala Thr Met Pro Val Val Pro Ser Val Ala Ser Leu Ala Pro Pro 
305                 310                 315                 320 


Gly Glu Ala Ser Leu Cys Leu Glu Glu Val Ala Pro Pro Ala Ser Gly 
                325                 330                 335     


Thr Arg Lys Ala Arg Val Leu Tyr Asp Tyr Glu Ala Ala Asp Ser Ser 
            340                 345                 350         


Glu Leu Ala Leu Leu Ala Asp Glu Leu Ile Thr Val Tyr Ser Leu Pro 
        355                 360                 365             


Gly Met Asp Pro Asp Trp Leu Ile Gly Glu Arg Gly Asn Lys Lys Gly 
    370                 375                 380                 


Lys Val Pro Val Thr Tyr Leu Glu Leu Leu Ser 
385                 390                 395 


<210> 6322
<211> 395
<212> PRT
<213> Homo sapiens

<400> 6322
Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Thr Val Pro Asp Phe 
            180                 185                 190         


Gln Glu Thr Arg Pro Arg Asn Tyr Ile Leu Ser Ala Ser Ala Ser Ala 
        195                 200                 205             


Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gln Glu Leu Arg Val Ala 
    210                 215                 220                 


Gln Thr Glu Phe Asp Arg Gln Ala Glu Val Thr Arg Leu Leu Leu Glu 
225                 230                 235                 240 


Gly Ile Ser Ser Thr His Val Asn His Leu Arg Cys Leu His Glu Phe 
                245                 250                 255     


Val Lys Ser Gln Thr Thr Tyr Tyr Ala Gln Cys Tyr Arg His Met Leu 
            260                 265                 270         


Asp Leu Gln Lys Gln Leu Gly Arg Phe Pro Gly Thr Phe Val Gly Thr 
        275                 280                 285             


Thr Glu Pro Ala Ser Pro Pro Leu Ser Ser Thr Ser Pro Thr Thr Ala 
    290                 295                 300                 


Ala Ala Thr Met Pro Val Val Pro Ser Val Ala Ser Leu Ala Pro Pro 
305                 310                 315                 320 


Gly Glu Ala Ser Leu Cys Leu Glu Glu Val Ala Pro Pro Ala Ser Gly 
                325                 330                 335     


Thr Arg Lys Ala Arg Val Leu Tyr Asp Tyr Glu Ala Ala Asp Ser Ser 
            340                 345                 350         


Glu Leu Ala Leu Leu Ala Asp Glu Leu Ile Thr Val Tyr Ser Leu Pro 
        355                 360                 365             


Gly Met Asp Pro Asp Trp Leu Ile Gly Glu Arg Gly Asn Lys Lys Gly 
    370                 375                 380                 


Lys Val Pro Val Thr Tyr Leu Glu Leu Leu Ser 
385                 390                 395 


<210> 6323
<211> 204
<212> PRT
<213> Homo sapiens

<400> 6323
Met Ser Trp Thr Cys Pro Arg Cys Gln Gln Pro Val Phe Phe Ala Glu 
1               5                   10                  15      


Lys Val Ser Ser Leu Gly Lys Asn Trp His Arg Phe Cys Leu Lys Cys 
            20                  25                  30          


Glu Arg Cys His Ser Ile Leu Ser Pro Gly Gly His Ala Glu His Asn 
        35                  40                  45              


Gly Arg Pro Tyr Cys His Lys Pro Cys Tyr Gly Ala Leu Phe Gly Pro 
    50                  55                  60                  


Arg Gly Val Asn Ile Gly Gly Val Gly Ser Tyr Leu Tyr Asn Pro Pro 
65                  70                  75                  80  


Thr Pro Ser Pro Gly Cys Thr Thr Pro Leu Ser Pro Ser Ser Phe Ser 
                85                  90                  95      


Pro Pro Arg Pro Arg Thr Gly Leu Pro Gln Gly Lys Lys Ser Pro Pro 
            100                 105                 110         


His Met Lys Thr Phe Thr Gly Glu Thr Ser Leu Cys Pro Gly Cys Gly 
        115                 120                 125             


Glu Pro Val Tyr Phe Ala Glu Lys Val Met Ser Leu Gly Arg Asn Trp 
    130                 135                 140                 


His Arg Pro Cys Leu Arg Cys Gln Arg Cys His Lys Thr Leu Thr Ala 
145                 150                 155                 160 


Gly Ser His Ala Glu His Asp Gly Val Pro Tyr Cys His Val Pro Cys 
                165                 170                 175     


Tyr Gly Tyr Leu Phe Gly Pro Lys Gly Val Asn Ile Gly Asp Val Gly 
            180                 185                 190         


Cys Tyr Ile Tyr Asp Pro Val Lys Ile Lys Phe Lys 
        195                 200                 


<210> 6324
<211> 406
<212> PRT
<213> Homo sapiens

<400> 6324
Met Glu Ser Leu Arg Gly Tyr Thr His Ser Asp Ile Gly Tyr Arg Ser 
1               5                   10                  15      


Leu Ala Val Gly Glu Asp Ile Glu Glu Val Asn Asp Glu Lys Leu Thr 
            20                  25                  30          


Val Thr Ser Leu Met Ala Arg Gly Gly Glu Asp Glu Glu Asn Thr Arg 
        35                  40                  45              


Ser Lys Pro Glu Tyr Gly Thr Glu Ala Glu Asn Asn Val Gly Thr Glu 
    50                  55                  60                  


Gly Ser Val Pro Ser Asp Asp Gln Asp Arg Glu Gly Gly Gly Gly His 
65                  70                  75                  80  


Glu Pro Glu Gln Gln Gln Glu Glu Pro Pro Leu Thr Lys Pro Glu Gln 
                85                  90                  95      


Gln Gln Glu Glu Pro Pro Leu Leu Glu Leu Lys Gln Glu Gln Glu Glu 
            100                 105                 110         


Pro Pro Gln Thr Thr Val Glu Gly Pro Gln Pro Ala Glu Gly Pro Gln 
        115                 120                 125             


Thr Ala Glu Gly Pro Gln Pro Pro Glu Arg Lys Arg Arg Arg Arg Thr 
    130                 135                 140                 


Ala Phe Thr Gln Phe Gln Leu Gln Glu Leu Glu Asn Phe Phe Asp Glu 
145                 150                 155                 160 


Ser Gln Tyr Pro Asp Val Val Ala Arg Glu Arg Leu Ala Ala Arg Leu 
                165                 170                 175     


Asn Leu Thr Glu Asp Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala 
            180                 185                 190         


Lys Trp Lys Arg Asn Gln Arg Val Leu Met Leu Arg Asn Thr Ala Thr 
        195                 200                 205             


Ala Asp Leu Ala His Pro Leu Asp Met Phe Leu Gly Gly Ala Tyr Tyr 
    210                 215                 220                 


Ala Ala Pro Ala Leu Asp Pro Ala Leu Cys Val His Leu Val Pro Gln 
225                 230                 235                 240 


Leu Pro Arg Pro Pro Val Leu Pro Val Pro Pro Met Pro Pro Arg Pro 
                245                 250                 255     


Pro Met Val Pro Met Pro Pro Arg Pro Pro Ile Ala Pro Met Pro Pro 
            260                 265                 270         


Met Ala Pro Val Pro Pro Gly Ser Arg Met Ala Pro Val Pro Pro Gly 
        275                 280                 285             


Pro Arg Met Ala Pro Val Pro Pro Trp Pro Pro Met Ala Pro Val Pro 
    290                 295                 300                 


Pro Trp Pro Pro Met Ala Pro Val Pro Thr Gly Pro Pro Met Ala Pro 
305                 310                 315                 320 


Val Pro Pro Gly Pro Pro Met Ala Arg Val Pro Pro Gly Pro Pro Met 
                325                 330                 335     


Ala Arg Val Pro Pro Gly Pro Pro Met Ala Pro Leu Pro Pro Gly Pro 
            340                 345                 350         


Pro Met Ala Pro Leu Pro Pro Gly Pro Pro Met Ala Pro Leu Pro Pro 
        355                 360                 365             


Gly Pro Pro Met Ala Pro Leu Pro Pro Arg Ser His Val Pro His Thr 
    370                 375                 380                 


Gly Leu Ala Pro Val His Ile Thr Trp Ala Pro Val Ile Asn Ser Tyr 
385                 390                 395                 400 


Tyr Ala Cys Pro Phe Phe 
                405     


<210> 6325
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6325
Met Ser Pro Ser Ala Lys Lys Arg Pro Lys Asn Ser Arg Val Ser Lys 
1               5                   10                  15      


Met Gln Asp Glu Lys Leu Arg Asp Glu Thr Glu Gln Pro Val Ser Lys 
            20                  25                  30          


Val Ile Glu Arg Asn Arg Leu Arg Thr Val Leu Lys Asn Leu Ser Leu 
        35                  40                  45              


Leu Lys Leu Leu Lys Ser Ser Asn Arg Arg Ile Gln Glu Leu His Lys 
    50                  55                  60                  


Leu Ala Lys Arg Cys Trp His Ser Leu Leu Ser Val Pro Lys Ile Leu 
65                  70                  75                  80  


Arg Ile Ser Ser Gly Glu Asn Ser Ala Cys Asn Lys Thr Lys Gln Asn 
                85                  90                  95      


Asn Glu Glu Phe Gln Glu Ile Gly Cys Ser Glu Lys Glu Leu Lys Ser 
            100                 105                 110         


Lys Lys Leu Glu Ser Thr Gly Asp Pro Lys Lys Lys Glu Tyr Lys Glu 
        115                 120                 125             


Trp Lys Ser Gln Val Gln Ser Gly Met Arg Asn Lys Glu Lys Thr Ser 
    130                 135                 140                 


Leu Ala Ala Met Pro Arg Lys Glu Lys His Ile Glu Pro Glu Val Pro 
145                 150                 155                 160 


Arg Thr Ser Arg Asp Asp Ser Leu Asn Pro Gly Val Gln Gly Arg Gln 
                165                 170                 175     


Pro Leu Thr Glu Gly Pro Arg Val Ile Phe Ile Lys Pro Tyr Arg Asn 
            180                 185                 190         


Arg Thr Pro Met Gly His Met Lys Gln Leu Asp Val Ala Asp Gln Trp 
        195                 200                 205             


Ile Trp Phe Glu Gly Leu Pro Thr Arg Ile His Leu Pro Ala Pro Arg 
    210                 215                 220                 


Val Met Cys Arg Ser Ser Thr Leu Arg Trp Val Lys Arg Arg Cys Thr 
225                 230                 235                 240 


Arg Phe Cys Ser Ala Ser Leu Glu Met Pro Met Trp His Pro Tyr Lys 
                245                 250                 255     


Val Asp Val Thr Trp Thr Arg Ala Arg Gly Ala Ser Arg Gly Trp Arg 
            260                 265                 270         


Ser Arg His Gln Leu Lys Gly Arg Asn Gly Trp Arg Asn Ser Arg Val 
        275                 280                 285             


Tyr Lys 
    290 


<210> 6326
<211> 547
<212> PRT
<213> Homo sapiens

<400> 6326
Met Ala Gly Thr Lys Asn Lys Thr Arg Ala Gln Ala Lys Thr Glu Lys 
1               5                   10                  15      


Lys Ala Ala Ile Gln Ala Lys Ala Gly Ala Glu Arg Glu Ala Thr Gly 
            20                  25                  30          


Val Val Arg Pro Val Ala Lys Thr Arg Ala Lys Ala Lys Ala Lys Thr 
        35                  40                  45              


Gly Ser Lys Thr Asp Ala Val Ala Glu Met Lys Ala Val Ser Lys Asn 
    50                  55                  60                  


Lys Val Val Ala Glu Thr Lys Glu Gly Ala Leu Ser Glu Pro Lys Thr 
65                  70                  75                  80  


Leu Gly Lys Ala Met Gly Asp Phe Thr Pro Lys Ala Gly Asn Glu Ser 
                85                  90                  95      


Thr Ser Ser Thr Cys Lys Asn Glu Ala Gly Thr Asp Ala Trp Phe Trp 
            100                 105                 110         


Ala Gly Glu Glu Ala Thr Ile Asn Ser Trp Phe Trp Asn Gly Glu Glu 
        115                 120                 125             


Ala Gly Asn Ser Phe Ser Thr Lys Asn Asp Lys Pro Glu Ile Gly Ala 
    130                 135                 140                 


Gln Val Cys Ala Glu Glu Leu Glu Pro Ala Ala Gly Ala Asp Cys Lys 
145                 150                 155                 160 


Pro Arg Ser Gly Ala Glu Glu Glu Glu Glu Glu Asn Val Ile Gly Asn 
                165                 170                 175     


Trp Phe Trp Glu Gly Asp Asp Thr Ser Phe Asp Pro Asn Pro Lys Pro 
            180                 185                 190         


Val Ser Arg Ile Val Lys Pro Gln Pro Val Tyr Glu Ile Asn Glu Lys 
        195                 200                 205             


Asn Arg Pro Lys Asp Trp Ser Glu Val Thr Ile Trp Pro Asn Ala Pro 
    210                 215                 220                 


Ala Val Thr Pro Ala Val Leu Gly Phe Arg Ser Gln Ala Pro Ser Glu 
225                 230                 235                 240 


Ala Ser Pro Pro Ser Tyr Ile Val Leu Ala Ser Ala Glu Glu Asn Ala 
                245                 250                 255     


Cys Ser Leu Pro Val Ala Thr Ala Cys Arg Pro Ser Arg Asn Thr Arg 
            260                 265                 270         


Ser Cys Ser Gln Pro Ile Pro Glu Cys Arg Phe Asp Ser Asp Pro Cys 
        275                 280                 285             


Ile Gln Thr Ile Asp Glu Ile Arg Arg Gln Ile Arg Ile Arg Glu Val 
    290                 295                 300                 


Asn Gly Ile Lys Pro Phe Ala Cys Pro Cys Lys Met Glu Cys Tyr Met 
305                 310                 315                 320 


Asp Ser Glu Glu Phe Glu Lys Leu Val Ser Leu Leu Lys Ser Thr Thr 
                325                 330                 335     


Asp Pro Leu Ile His Lys Ile Ala Arg Ile Ala Met Gly Val His Asn 
            340                 345                 350         


Val His Pro Phe Ala Gln Glu Phe Ile Asn Glu Val Gly Val Val Thr 
        355                 360                 365             


Leu Ile Glu Ser Leu Leu Ser Phe Pro Ser Pro Glu Met Arg Lys Lys 
    370                 375                 380                 


Thr Val Ile Thr Leu Asn Pro Pro Ser Gly Asp Glu Arg Gln Arg Lys 
385                 390                 395                 400 


Ile Glu Leu His Val Lys His Met Cys Lys Glu Thr Met Ser Phe Pro 
                405                 410                 415     


Leu Asn Ser Pro Gly Gln Gln Ser Gly Leu Lys Ile Leu Gly Gln Leu 
            420                 425                 430         


Thr Thr Asp Phe Val His His Tyr Ile Val Ala Asn Tyr Phe Ser Glu 
        435                 440                 445             


Leu Phe His Leu Leu Ser Ser Gly Asn Cys Lys Thr Arg Asn Leu Val 
    450                 455                 460                 


Leu Lys Leu Leu Leu Asn Met Ser Glu Asn Pro Thr Ala Ala Arg Asp 
465                 470                 475                 480 


Met Ile Asn Met Lys Ala Leu Ala Ala Leu Lys Leu Ile Phe Asn Gln 
                485                 490                 495     


Lys Glu Ala Lys Ala Asn Leu Val Ser Gly Val Ala Ile Phe Ile Asn 
            500                 505                 510         


Ile Lys Glu His Ile Arg Lys Gly Ser Ile Val Val Val Asp His Leu 
        515                 520                 525             


Ser Tyr Asn Thr Leu Met Ala Ile Phe Arg Glu Val Lys Glu Ile Ile 
    530                 535                 540                 


Glu Thr Met 
545         


<210> 6327
<211> 626
<212> PRT
<213> Homo sapiens

<400> 6327
Met Cys Ser Thr Leu Lys Lys Cys Gly Thr Tyr Arg Thr Glu Val Ala 
1               5                   10                  15      


Glu Cys His Asp His Gly Ser Thr Phe Gln Gly Arg Lys Lys Gly Gly 
            20                  25                  30          


Ser Ser Phe Arg Asp Asn Phe Asp Lys Arg Ser Cys His Tyr Glu His 
        35                  40                  45              


Gly Gly Tyr Glu Arg Pro Pro Ser His Cys Gln Glu Asn Asp Gly Ser 
    50                  55                  60                  


Val Glu Met Arg Asp Val His Lys Asp Gln Gln Leu Arg His Thr Pro 
65                  70                  75                  80  


Tyr Ser Ile Arg Cys Glu Arg Arg Met Lys Trp His Ser Glu Asp Glu 
                85                  90                  95      


Ile Arg Ile Thr Thr Trp Arg Asn Arg Lys Pro Pro Glu Arg Lys Met 
            100                 105                 110         


Ser Gln Asn Thr Gln Asp Gly Tyr Thr Arg Asn Trp Phe Lys Val Thr 
        115                 120                 125             


Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser Ile 
    130                 135                 140                 


Gln Ser His Cys Ser Asp Arg Phe Thr Pro Val Asp Phe His Tyr Val 
145                 150                 155                 160 


Arg Asn Arg Ala Cys Phe Phe Val Gln Asp Ala Ser Ala Ala Ser Ala 
                165                 170                 175     


Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys Ile 
            180                 185                 190         


Cys Ile Phe Val Asn His Ser Thr Ala Pro Tyr Ser Val Lys Asn Lys 
        195                 200                 205             


Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys Arg 
    210                 215                 220                 


Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe Asp 
225                 230                 235                 240 


Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg Asn 
                245                 250                 255     


Cys Met Ala Ala Thr Leu Lys Ile Ile Glu Arg Asn Phe Pro Glu Leu 
            260                 265                 270         


Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp Gly Leu 
        275                 280                 285             


Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn Leu Ser 
    290                 295                 300                 


Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys Gly Leu 
305                 310                 315                 320 


Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser Thr Phe 
                325                 330                 335     


Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe Pro Lys 
            340                 345                 350         


Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile Val Asp 
        355                 360                 365             


Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe Thr Gly 
    370                 375                 380                 


Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln Tyr Tyr 
385                 390                 395                 400 


Ser Ile Tyr Asp Ser Gly Asp Arg Gln Gly Leu Leu Gly Ala Tyr His 
                405                 410                 415     


Asp Glu Ala Cys Phe Ser Leu Ala Ile Pro Phe Asp Pro Lys Asp Ser 
            420                 425                 430         


Ala Pro Ser Ser Leu Cys Lys Tyr Phe Glu Asp Ser Arg Asn Met Lys 
        435                 440                 445             


Thr Leu Lys Asp Pro Tyr Leu Lys Gly Glu Leu Leu Arg Arg Thr Lys 
    450                 455                 460                 


Arg Asp Ile Val Asp Ser Leu Ser Ala Leu Pro Lys Thr Gln His Asp 
465                 470                 475                 480 


Leu Ser Ser Ile Leu Val Asp Val Trp Cys Gln Thr Glu Arg Met Leu 
                485                 490                 495     


Cys Phe Ser Val Asn Gly Val Phe Lys Glu Val Glu Gly Gln Ser Gln 
            500                 505                 510         


Gly Ser Val Leu Ala Phe Thr Arg Thr Phe Ile Ala Thr Pro Gly Ser 
        515                 520                 525             


Ser Ser Ser Leu Cys Ile Val Asn Asp Glu Leu Phe Val Arg Asp Ala 
    530                 535                 540                 


Ser Pro Gln Glu Thr Gln Ser Ala Phe Ser Ile Pro Val Ser Thr Leu 
545                 550                 555                 560 


Ser Ser Ser Ser Glu Pro Ser Leu Ser Gln Glu Gln Gln Glu Met Val 
                565                 570                 575     


Gln Ala Phe Ser Ala Gln Ser Gly Met Lys Leu Glu Trp Ser Gln Lys 
            580                 585                 590         


Cys Leu Gln Asp Asn Glu Trp Asn Tyr Thr Arg Ala Gly Gln Ala Phe 
        595                 600                 605             


Thr Met Leu Gln Thr Glu Gly Lys Ile Pro Ala Glu Ala Phe Lys Gln 
    610                 615                 620                 


Ile Ser 
625     


<210> 6328
<211> 626
<212> PRT
<213> Homo sapiens

<400> 6328
Met Cys Ser Thr Leu Lys Lys Cys Gly Thr Tyr Arg Thr Glu Val Ala 
1               5                   10                  15      


Glu Cys His Asp His Gly Ser Thr Phe Gln Gly Arg Lys Lys Gly Gly 
            20                  25                  30          


Ser Ser Phe Arg Asp Asn Phe Asp Lys Arg Ser Cys His Tyr Glu His 
        35                  40                  45              


Gly Gly Tyr Glu Arg Pro Pro Ser His Cys Gln Glu Asn Asp Gly Ser 
    50                  55                  60                  


Val Glu Met Arg Asp Val His Lys Asp Gln Gln Leu Arg His Thr Pro 
65                  70                  75                  80  


Tyr Ser Ile Arg Cys Glu Arg Arg Met Lys Trp His Ser Glu Asp Glu 
                85                  90                  95      


Ile Arg Ile Thr Thr Trp Arg Asn Arg Lys Pro Pro Glu Arg Lys Met 
            100                 105                 110         


Ser Gln Asn Thr Gln Asp Gly Tyr Thr Arg Asn Trp Phe Lys Val Thr 
        115                 120                 125             


Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser Ile 
    130                 135                 140                 


Gln Ser His Cys Ser Asp Arg Phe Thr Pro Val Asp Phe His Tyr Val 
145                 150                 155                 160 


Arg Asn Arg Ala Cys Phe Phe Val Gln Asp Ala Ser Ala Ala Ser Ala 
                165                 170                 175     


Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys Ile 
            180                 185                 190         


Cys Ile Phe Val Asn His Ser Thr Ala Pro Tyr Ser Val Lys Asn Lys 
        195                 200                 205             


Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys Arg 
    210                 215                 220                 


Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe Asp 
225                 230                 235                 240 


Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg Asn 
                245                 250                 255     


Cys Met Ala Ala Thr Leu Lys Ile Ile Glu Arg Asn Phe Pro Glu Leu 
            260                 265                 270         


Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp Gly Leu 
        275                 280                 285             


Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn Leu Ser 
    290                 295                 300                 


Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys Gly Leu 
305                 310                 315                 320 


Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser Thr Phe 
                325                 330                 335     


Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe Pro Lys 
            340                 345                 350         


Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile Val Asp 
        355                 360                 365             


Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe Thr Gly 
    370                 375                 380                 


Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln Tyr Tyr 
385                 390                 395                 400 


Ser Ile Tyr Asp Ser Gly Asp Arg Gln Gly Leu Leu Gly Ala Tyr His 
                405                 410                 415     


Asp Glu Ala Cys Phe Ser Leu Ala Ile Pro Phe Asp Pro Lys Asp Ser 
            420                 425                 430         


Ala Pro Ser Ser Leu Cys Lys Tyr Phe Glu Asp Ser Arg Asn Met Lys 
        435                 440                 445             


Thr Leu Lys Asp Pro Tyr Leu Lys Gly Glu Leu Leu Arg Arg Thr Lys 
    450                 455                 460                 


Arg Asp Ile Val Asp Ser Leu Ser Ala Leu Pro Lys Thr Gln His Asp 
465                 470                 475                 480 


Leu Ser Ser Ile Leu Val Asp Val Trp Cys Gln Thr Glu Arg Met Leu 
                485                 490                 495     


Cys Phe Ser Val Asn Gly Val Phe Lys Glu Val Glu Gly Gln Ser Gln 
            500                 505                 510         


Gly Ser Val Leu Ala Phe Thr Arg Thr Phe Ile Ala Thr Pro Gly Ser 
        515                 520                 525             


Ser Ser Ser Leu Cys Ile Val Asn Asp Glu Leu Phe Val Arg Asp Ala 
    530                 535                 540                 


Ser Pro Gln Glu Thr Gln Ser Ala Phe Ser Ile Pro Val Ser Thr Leu 
545                 550                 555                 560 


Ser Ser Ser Ser Glu Pro Ser Leu Ser Gln Glu Gln Gln Glu Met Val 
                565                 570                 575     


Gln Ala Phe Ser Ala Gln Ser Gly Met Lys Leu Glu Trp Ser Gln Lys 
            580                 585                 590         


Cys Leu Gln Asp Asn Glu Trp Asn Tyr Thr Arg Ala Gly Gln Ala Phe 
        595                 600                 605             


Thr Met Leu Gln Thr Glu Gly Lys Ile Pro Ala Glu Ala Phe Lys Gln 
    610                 615                 620                 


Ile Ser 
625     


<210> 6329
<211> 409
<212> PRT
<213> Homo sapiens

<400> 6329
Met Lys Trp His Ser Glu Asp Glu Ile Arg Ile Thr Thr Trp Arg Asn 
1               5                   10                  15      


Arg Lys Pro Pro Glu Arg Lys Met Ser Gln Asn Thr Gln Asp Gly Tyr 
            20                  25                  30          


Thr Arg Asn Trp Phe Lys Val Thr Ile Pro Tyr Gly Ile Lys Tyr Asp 
        35                  40                  45              


Lys Ala Trp Leu Met Asn Ser Ile Gln Ser His Cys Ser Asp Arg Phe 
    50                  55                  60                  


Thr Pro Val Asp Phe His Tyr Val Arg Asn Arg Ala Cys Phe Phe Val 
65                  70                  75                  80  


Gln Asp Ala Ser Ala Ala Ser Ala Leu Lys Asp Val Ser Tyr Lys Ile 
                85                  90                  95      


Tyr Asp Asp Glu Asn Gln Lys Ile Cys Ile Phe Val Asn His Ser Thr 
            100                 105                 110         


Ala Pro Tyr Ser Val Lys Asn Lys Leu Lys Pro Gly Gln Met Glu Met 
        115                 120                 125             


Leu Lys Leu Thr Met Asn Lys Arg Tyr Asn Val Ser Gln Gln Ala Leu 
    130                 135                 140                 


Asp Leu Gln Asn Leu Arg Phe Asp Pro Asp Leu Met Gly Arg Asp Ile 
145                 150                 155                 160 


Asp Ile Ile Leu Asn Arg Arg Asn Cys Met Ala Ala Thr Leu Lys Ile 
                165                 170                 175     


Ile Glu Arg Asn Phe Pro Glu Leu Leu Ser Leu Asn Leu Cys Asn Asn 
            180                 185                 190         


Lys Leu Tyr Gln Leu Asp Gly Leu Ser Asp Ile Thr Glu Lys Ala Pro 
        195                 200                 205             


Lys Val Lys Thr Leu Asn Leu Ser Lys Asn Lys Leu Glu Ser Ala Trp 
    210                 215                 220                 


Glu Leu Gly Lys Val Lys Gly Leu Lys Leu Glu Glu Leu Trp Leu Glu 
225                 230                 235                 240 


Gly Asn Pro Leu Cys Ser Thr Phe Ser Asp Gln Ser Ala Tyr Val Ser 
                245                 250                 255     


Ala Ile Arg Asp Cys Phe Pro Lys Leu Leu Arg Leu Asp Gly Arg Glu 
            260                 265                 270         


Leu Ser Ala Pro Val Ile Val Asp Ile Asp Ser Ser Glu Thr Met Lys 
        275                 280                 285             


Pro Cys Lys Glu Asn Phe Thr Gly Ser Glu Thr Leu Lys His Leu Val 
    290                 295                 300                 


Leu Gln Phe Leu Gln Gln Tyr Tyr Ser Ile Tyr Asp Ser Gly Asp Arg 
305                 310                 315                 320 


Gln Gly Leu Leu Gly Ala Tyr His Asp Glu Ala Cys Phe Ser Leu Ala 
                325                 330                 335     


Ile Pro Phe Asp Pro Lys Asp Ser Ala Pro Ser Ser Leu Cys Lys Tyr 
            340                 345                 350         


Phe Glu Asp Ser Arg Asn Met Lys Thr Leu Lys Asp Pro Tyr Leu Lys 
        355                 360                 365             


Gly Glu Leu Leu Arg Arg Thr Lys Arg Asp Ile Val Asp Ser Leu Ser 
    370                 375                 380                 


Ala Leu Pro Lys Thr Gln His Asp Leu Ser Ser Ile Leu Val Asp Val 
385                 390                 395                 400 


Trp Cys Gln Thr Val Pro Ser Gly Gln 
                405                 


<210> 6330
<211> 441
<212> PRT
<213> Homo sapiens

<400> 6330
Met Ala Ser Val Ala Ala Ala Arg Ala Val Pro Val Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Arg Thr Leu Pro Leu Val Val Ile Leu Gly Ala Thr 
            20                  25                  30          


Gly Thr Gly Lys Ser Thr Leu Ala Leu Gln Leu Gly Gln Arg Leu Gly 
        35                  40                  45              


Gly Glu Ile Val Ser Ala Asp Ser Met Gln Val Tyr Glu Gly Leu Asp 
    50                  55                  60                  


Ile Ile Thr Asn Lys Val Ser Ala Gln Glu Gln Arg Ile Cys Arg His 
65                  70                  75                  80  


His Met Ile Ser Phe Val Asp Pro Leu Val Thr Asn Tyr Thr Val Val 
                85                  90                  95      


Asp Phe Arg Asn Arg Ala Thr Ala Leu Ile Glu Asp Ile Phe Ala Arg 
            100                 105                 110         


Asp Lys Ile Pro Ile Val Val Gly Gly Thr Asn Tyr Tyr Ile Glu Ser 
        115                 120                 125             


Leu Leu Trp Lys Val Leu Val Asn Thr Lys Pro Gln Glu Met Gly Thr 
    130                 135                 140                 


Glu Lys Val Ile Asp Arg Lys Val Glu Leu Glu Lys Glu Asp Gly Leu 
145                 150                 155                 160 


Val Leu His Lys Arg Leu Ser Gln Val Asp Pro Glu Met Ala Ala Lys 
                165                 170                 175     


Leu His Pro His Asp Lys Arg Lys Val Ala Arg Ser Leu Gln Val Phe 
            180                 185                 190         


Glu Glu Thr Gly Ile Ser His Ser Glu Phe Leu His Arg Gln His Thr 
        195                 200                 205             


Glu Glu Gly Gly Gly Pro Leu Gly Gly Pro Leu Lys Phe Ser Asn Pro 
    210                 215                 220                 


Cys Ile Leu Trp Leu His Ala Asp Gln Ala Val Leu Asp Glu Arg Leu 
225                 230                 235                 240 


Asp Lys Arg Val Asp Asp Met Leu Ala Ala Gly Leu Leu Glu Glu Leu 
                245                 250                 255     


Arg Asp Phe His Arg Arg Tyr Asn Gln Lys Asn Val Ser Glu Asn Ser 
            260                 265                 270         


Gln Asp Tyr Gln His Gly Ile Phe Gln Ser Ile Gly Phe Lys Glu Phe 
        275                 280                 285             


His Glu Tyr Leu Ile Thr Glu Gly Lys Cys Thr Leu Glu Thr Ser Asn 
    290                 295                 300                 


Gln Leu Leu Lys Lys Gly Pro Gly Pro Ile Val Pro Pro Val Tyr Gly 
305                 310                 315                 320 


Leu Glu Val Ser Asp Val Ser Lys Trp Glu Glu Ser Val Leu Glu Pro 
                325                 330                 335     


Ala Leu Glu Ile Val Gln Ser Phe Ile Gln Gly His Lys Pro Thr Ala 
            340                 345                 350         


Thr Pro Ile Lys Met Pro Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr 
        355                 360                 365             


His Leu Cys Asp Leu Cys Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp 
    370                 375                 380                 


Ala Ala His Ile Lys Ser Lys Ser His Leu Asn Gln Leu Lys Lys Arg 
385                 390                 395                 400 


Arg Arg Leu Asp Ser Asp Ala Val Asn Thr Ile Glu Ser Gln Ser Val 
                405                 410                 415     


Ser Pro Asp His Asn Lys Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln 
            420                 425                 430         


Asn Asp Gln Glu Leu Lys Cys Ser Val 
        435                 440     


<210> 6331
<211> 385
<212> PRT
<213> Homo sapiens

<400> 6331
Met Ala Ser Val Ala Ala Ala Arg Ala Val Pro Val Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Arg Thr Leu Pro Leu Val Val Ile Leu Gly Ala Thr 
            20                  25                  30          


Gly Thr Gly Lys Ser Thr Leu Ala Leu Gln Leu Gly Gln Arg Leu Gly 
        35                  40                  45              


Gly Glu Ile Val Ser Ala Asp Ser Met Gln Pro Gln Glu Met Gly Thr 
    50                  55                  60                  


Glu Lys Val Ile Asp Arg Lys Val Glu Leu Glu Lys Glu Asp Gly Leu 
65                  70                  75                  80  


Val Leu His Lys Arg Leu Ser Gln Val Asp Pro Glu Met Ala Ala Lys 
                85                  90                  95      


Leu His Pro His Asp Lys Arg Lys Val Ala Arg Ser Leu Gln Val Phe 
            100                 105                 110         


Glu Glu Thr Gly Ile Ser His Ser Glu Phe Leu His Arg Gln His Thr 
        115                 120                 125             


Glu Glu Gly Gly Gly Pro Leu Gly Gly Pro Leu Lys Phe Ser Asn Pro 
    130                 135                 140                 


Cys Ile Leu Trp Leu His Ala Asp Gln Ala Asp Glu Arg Leu Asp Lys 
145                 150                 155                 160 


Arg Val Asp Asp Met Leu Ala Ala Gly Leu Leu Glu Glu Leu Arg Asp 
                165                 170                 175     


Phe His Arg Arg Tyr Asn Gln Lys Asn Val Ser Glu Asn Ser Gln Asp 
            180                 185                 190         


Tyr Gln His Gly Ile Phe Gln Ser Ile Gly Phe Lys Glu Phe His Glu 
        195                 200                 205             


Tyr Leu Ile Thr Glu Gly Lys Cys Thr Leu Glu Thr Ser Asn Gln Leu 
    210                 215                 220                 


Leu Lys Lys Gly Ile Glu Ala Leu Lys Gln Val Thr Lys Arg Tyr Ala 
225                 230                 235                 240 


Arg Lys Gln Asn Arg Trp Val Lys Asn Arg Phe Leu Ser Arg Pro Gly 
                245                 250                 255     


Pro Ile Val Pro Pro Val Tyr Gly Leu Glu Val Ser Asp Val Ser Lys 
            260                 265                 270         


Trp Glu Glu Ser Val Leu Glu Pro Ala Leu Glu Ile Val Gln Ser Phe 
        275                 280                 285             


Ile Gln Gly His Lys Pro Thr Ala Thr Pro Ile Lys Met Pro Tyr Asn 
    290                 295                 300                 


Glu Ala Glu Asn Lys Arg Ser Tyr His Leu Cys Asp Leu Cys Asp Arg 
305                 310                 315                 320 


Ile Ile Ile Gly Asp Arg Glu Trp Ala Ala His Ile Lys Ser Lys Ser 
                325                 330                 335     


His Leu Asn Gln Leu Lys Lys Arg Arg Arg Leu Asp Ser Asp Ala Val 
            340                 345                 350         


Asn Thr Ile Glu Ser Gln Ser Val Ser Pro Asp His Asn Lys Glu Pro 
        355                 360                 365             


Lys Glu Lys Gly Ser Pro Gly Gln Asn Asp Gln Glu Leu Lys Cys Ser 
    370                 375                 380                 


Val 
385 


<210> 6332
<211> 328
<212> PRT
<213> Homo sapiens

<400> 6332
Met Lys Arg Pro Lys Glu Pro Ser Gly Ser Asp Gly Glu Ser Asp Gly 
1               5                   10                  15      


Pro Ile Asp Val Gly Gln Glu Gly Gln Leu Ser Gln Met Ala Arg Pro 
            20                  25                  30          


Leu Ser Thr Pro Ser Ser Ser Gln Met Gln Ala Arg Lys Lys His Arg 
        35                  40                  45              


Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn Ser Ser Leu Ser 
    50                  55                  60                  


Glu Leu Arg Arg Leu Val Pro Thr Ala Phe Glu Lys Gln Gly Ser Ser 
65                  70                  75                  80  


Lys Leu Glu Lys Ala Glu Val Leu Gln Met Thr Val Asp His Leu Lys 
                85                  90                  95      


Met Leu His Ala Thr Gly Gly Thr Gly Phe Phe Asp Ala Arg Ala Leu 
            100                 105                 110         


Ala Val Asp Phe Arg Ser Ile Gly Phe Arg Glu Cys Leu Thr Glu Val 
        115                 120                 125             


Ile Arg Tyr Leu Gly Val Leu Glu Gly Pro Ser Ser Arg Ala Asp Pro 
    130                 135                 140                 


Val Arg Ile Arg Leu Leu Ser His Leu Asn Ser Tyr Ala Ala Glu Met 
145                 150                 155                 160 


Glu Pro Ser Pro Thr Pro Thr Gly Pro Leu Ala Phe Pro Ala Trp Pro 
                165                 170                 175     


Trp Ser Phe Phe His Ser Cys Pro Gly Leu Pro Ala Leu Ser Asn Gln 
            180                 185                 190         


Leu Ala Ile Leu Gly Arg Val Pro Ser Pro Val Leu Pro Gly Val Ser 
        195                 200                 205             


Ser Pro Ala Tyr Pro Ile Pro Ala Leu Arg Thr Ala Pro Leu Arg Arg 
    210                 215                 220                 


Ala Thr Gly Ile Ile Leu Pro Ala Arg Arg Asn Val Leu Pro Ser Arg 
225                 230                 235                 240 


Gly Ala Ser Ser Thr Arg Arg Ala Arg Pro Leu Glu Arg Pro Ala Thr 
                245                 250                 255     


Pro Val Pro Val Ala Pro Ser Ser Arg Ala Ala Arg Ser Ser His Ile 
            260                 265                 270         


Ala Pro Leu Leu Gln Ser Ser Ser Pro Thr Pro Pro Gly Pro Thr Gly 
        275                 280                 285             


Ser Ala Ala Tyr Val Ala Val Pro Thr Pro Asn Ser Ser Ser Pro Gly 
    290                 295                 300                 


Pro Ala Gly Arg Pro Ala Gly Ala Met Leu Tyr His Ser Trp Val Ser 
305                 310                 315                 320 


Glu Ile Thr Glu Ile Gly Ala Phe 
                325             


<210> 6333
<211> 753
<212> PRT
<213> Homo sapiens

<400> 6333
Met Glu Thr Phe Glu Pro Ile Ser Gln Glu Pro Leu Ser Gln Ala Ser 
1               5                   10                  15      


Tyr Asp Lys Ala Pro Asp Pro Val Pro Glu Leu Gln Asp Ser Phe Tyr 
            20                  25                  30          


Ala Glu Leu Gln Arg Ala Glu Ser Leu Gln Glu Lys Ser Ile Lys Glu 
        35                  40                  45              


Ala Lys Thr Lys Cys Arg Thr Ile Ala Ser Leu Leu Thr Ala Ala Pro 
    50                  55                  60                  


Asn Pro His Ser Lys Gly Val Leu Met Phe Lys Lys Arg Arg Gln Arg 
65                  70                  75                  80  


Ala Lys Lys Tyr Thr Leu Val Ser Phe Gly Ala Ala Ala Gly Thr Gly 
                85                  90                  95      


Ala Glu Glu Glu Asp Gly Val Pro Pro Thr Ser Glu Ser Glu Leu Asp 
            100                 105                 110         


Glu Glu Ala Phe Ser Asp Ala Arg Ser Leu Thr Asn Gln Ser Asp Trp 
        115                 120                 125             


Asp Ser Pro Tyr Leu Asp Met Glu Leu Ala Arg Ala Gly Ser Arg Ala 
    130                 135                 140                 


Ser Glu Gly Gln Gly Ser Gly Leu Gly Gly Gln Leu Ser Glu Val Ser 
145                 150                 155                 160 


Gly Arg Gly Val Gln Leu Phe Glu Gln Gln Arg Gln Arg Ala Asp Ser 
                165                 170                 175     


Ser Thr Gln Glu Leu Ala Arg Val Glu Pro Ala Ala Met Leu Asn Gly 
            180                 185                 190         


Glu Gly Leu Gln Ser Pro Pro Arg Ala Gln Ser Ala Pro Pro Glu Ala 
        195                 200                 205             


Ala Val Leu Pro Pro Ser Pro Leu Pro Ala Pro Val Ala Ser Pro Arg 
    210                 215                 220                 


Pro Phe Gln Pro Gly Gly Gly Ala Pro Thr Pro Ala Pro Ser Ile Phe 
225                 230                 235                 240 


Asn Arg Ser Ala Arg Pro Phe Thr Pro Gly Leu Gln Gly Gln Arg Pro 
                245                 250                 255     


Thr Thr Thr Ser Val Ile Phe Arg Pro Leu Ala Pro Lys Arg Ala Asn 
            260                 265                 270         


Asp Ser Leu Gly Gly Leu Ser Pro Ala Pro Pro Pro Phe Leu Ser Ser 
        275                 280                 285             


Gln Gly Pro Thr Pro Leu Pro Ser Phe Thr Ser Gly Val Pro Ser His 
    290                 295                 300                 


Ala Pro Val Ser Gly Ser Pro Ser Thr Pro Arg Ser Ser Gly Pro Val 
305                 310                 315                 320 


Thr Ala Thr Ser Ser Leu Tyr Ile Pro Ala Pro Ser Arg Pro Val Thr 
                325                 330                 335     


Pro Gly Gly Ala Pro Glu Pro Pro Ala Pro Pro Ser Ala Ala Ala Met 
            340                 345                 350         


Thr Ser Thr Ala Ser Ile Phe Leu Ser Ala Pro Leu Arg Pro Ser Ala 
        355                 360                 365             


Arg Pro Glu Ala Pro Ala Pro Gly Pro Gly Ala Pro Glu Pro Pro Ser 
    370                 375                 380                 


Ala Arg Glu Gln Arg Ile Ser Val Pro Ala Ala Arg Thr Gly Ile Leu 
385                 390                 395                 400 


Gln Glu Ala Arg Arg Arg Gly Thr Arg Lys Gln Met Phe Arg Pro Gly 
                405                 410                 415     


Lys Glu Glu Thr Lys Asn Ser Pro Asn Pro Glu Leu Leu Ser Leu Val 
            420                 425                 430         


Gln Asn Leu Asp Glu Lys Pro Arg Ala Gly Gly Ala Glu Ser Gly Pro 
        435                 440                 445             


Glu Glu Asp Ala Leu Ser Leu Gly Ala Glu Ala Cys Asn Phe Met Gln 
    450                 455                 460                 


Pro Val Gly Ala Arg Ser Tyr Lys Thr Leu Pro His Val Thr Pro Lys 
465                 470                 475                 480 


Thr Pro Pro Pro Met Ala Pro Lys Thr Pro Pro Pro Met Thr Pro Lys 
                485                 490                 495     


Thr Pro Pro Pro Val Ala Pro Lys Pro Pro Ser Arg Gly Leu Leu Asp 
            500                 505                 510         


Gly Leu Val Asn Gly Ala Ala Ser Ser Ala Gly Ile Pro Glu Pro Pro 
        515                 520                 525             


Arg Leu Gln Gly Arg Gly Gly Glu Leu Phe Ala Lys Arg Gln Ser Arg 
    530                 535                 540                 


Ala Asp Arg Tyr Val Val Glu Gly Thr Pro Gly Pro Gly Leu Gly Pro 
545                 550                 555                 560 


Arg Pro Arg Ser Pro Ser Pro Thr Pro Ser Leu Pro Pro Ser Trp Lys 
                565                 570                 575     


Tyr Ser Pro Asn Ile Arg Ala Pro Pro Pro Ile Ala Tyr Asn Pro Leu 
            580                 585                 590         


Leu Ser Pro Phe Phe Pro Gln Ala Ala Arg Thr Leu Pro Lys Ala Gln 
        595                 600                 605             


Ser Gln Gly Pro Arg Ala Thr Pro Lys Gln Gly Ile Lys Ala Leu Asp 
    610                 615                 620                 


Phe Met Arg His Gln Pro Tyr Gln Leu Lys Thr Ala Met Phe Cys Phe 
625                 630                 635                 640 


Asp Glu Val Pro Pro Thr Pro Gly Pro Ile Ala Ser Gly Ser Pro Lys 
                645                 650                 655     


Thr Ala Arg Val Gln Glu Ile Arg Arg Phe Ser Thr Pro Ala Pro Gln 
            660                 665                 670         


Pro Thr Ala Glu Pro Leu Ala Pro Thr Val Leu Ala Pro Arg Ala Ala 
        675                 680                 685             


Thr Thr Leu Asp Glu Pro Ile Trp Arg Thr Glu Leu Ala Ser Ala Pro 
    690                 695                 700                 


Val Pro Ser Pro Ala Pro Pro Pro Glu Ala Pro Arg Gly Leu Gly Ala 
705                 710                 715                 720 


Ser Pro Ser Ser Cys Gly Phe Gln Val Ala Arg Pro Arg Phe Ser Ala 
                725                 730                 735     


Thr Arg Thr Gly Leu Gln Ala His Val Trp Arg Pro Gly Ala Gly His 
            740                 745                 750         


Gln 
    


<210> 6334
<211> 346
<212> PRT
<213> Homo sapiens

<400> 6334
Met Glu Ser Val Ser Cys Ser Ala Ala Ala Val Arg Thr Gly Asp Met 
1               5                   10                  15      


Glu Ser Gln Arg Asp Leu Ser Leu Val Pro Glu Arg Leu Gln Arg Arg 
            20                  25                  30          


Glu Gln Glu Arg Gln Leu Glu Val Glu Arg Arg Lys Gln Lys Arg Gln 
        35                  40                  45              


Asn Gln Glu Val Glu Lys Glu Asn Ser His Phe Phe Val Ala Thr Phe 
    50                  55                  60                  


Val Arg Glu Arg Ala Ala Val Glu Glu Leu Leu Glu Arg Ala Glu Ser 
65                  70                  75                  80  


Val Glu Arg Leu Glu Glu Ala Ala Ser Arg Leu Gln Gly Leu Gln Lys 
                85                  90                  95      


Leu Ile Asn Asp Ser Val Phe Phe Leu Ala Ala Tyr Asp Leu Arg Gln 
            100                 105                 110         


Gly Gln Glu Ala Leu Ala Arg Leu Gln Ala Ala Leu Ala Glu Arg Arg 
        115                 120                 125             


Arg Gly Leu Gln Pro Lys Lys Arg Phe Ala Phe Lys Thr Arg Gly Lys 
    130                 135                 140                 


Asp Ala Ala Ser Ser Thr Lys Val Asp Ala Ala Pro Gly Ile Pro Pro 
145                 150                 155                 160 


Ala Val Glu Ser Ile Gln Asp Ser Pro Leu Pro Lys Lys Ala Glu Gly 
                165                 170                 175     


Asp Leu Gly Pro Ser Trp Val Cys Gly Phe Ser Asn Leu Glu Ser Gln 
            180                 185                 190         


Val Leu Glu Lys Arg Ala Ser Glu Leu His Gln Arg Asp Val Leu Leu 
        195                 200                 205             


Thr Glu Leu Ser Asn Cys Thr Val Arg Leu Tyr Gly Asn Pro Asn Thr 
    210                 215                 220                 


Leu Arg Leu Thr Lys Ala His Ser Cys Lys Leu Leu Cys Gly Pro Val 
225                 230                 235                 240 


Ser Thr Ser Val Phe Leu Glu Asp Cys Ser Asp Cys Val Leu Ala Val 
                245                 250                 255     


Ala Cys Gln Gln Leu Arg Ile His Ser Thr Lys Asp Thr Arg Ile Phe 
            260                 265                 270         


Leu Gln Val Thr Ser Arg Ala Ile Val Glu Asp Cys Ser Gly Ile Gln 
        275                 280                 285             


Phe Ala Pro Tyr Thr Trp Ser Tyr Pro Glu Ile Asp Lys Asp Phe Glu 
    290                 295                 300                 


Ser Ser Gly Leu Asp Arg Ser Lys Asn Asn Trp Asn Asp Val Asp Asp 
305                 310                 315                 320 


Phe Asn Trp Leu Ala Arg Asp Met Ala Ser Pro Asn Trp Ser Ile Leu 
                325                 330                 335     


Pro Glu Glu Glu Arg Asn Ile Gln Trp Asp 
            340                 345     


<210> 6335
<211> 522
<212> PRT
<213> Homo sapiens

<400> 6335
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr 
1               5                   10                  15      


Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val 
            20                  25                  30          


Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His Gly Gln Asn 
        35                  40                  45              


Asn Pro Val Gly Asp Tyr Glu His Ala Asp Asp Gln Ala Glu Glu Asp 
    50                  55                  60                  


Ala Leu Gln Met Ala Val Gly Tyr Phe Glu Lys Gly Pro Ile Lys Ala 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Thr Leu Glu Lys His Leu Lys Thr Val Glu 
                85                  90                  95      


Asn Val Ala Trp Lys Asn Gly Leu Ala Ser Glu Glu Ile Asp Ile Leu 
            100                 105                 110         


Leu Asn Ile Ala Leu Ser Gly Lys Phe Gly Asn Ala Val Asn Thr Arg 
        115                 120                 125             


Ile Leu Lys Cys Met Ile Pro Ala Thr Val Ile Ser Glu Asp Ser Val 
    130                 135                 140                 


Val Lys Ala Val Ser Trp Leu Cys Val Gly Lys Cys Ser Gly Ser Thr 
145                 150                 155                 160 


Lys Val Leu Phe Tyr Arg Trp Leu Val Ala Met Phe Asp Phe Ile Asp 
                165                 170                 175     


Arg Lys Glu Gln Ile Asn Leu Leu Tyr Gly Phe Phe Phe Ala Ser Leu 
            180                 185                 190         


Gln Asp Asp Ala Leu Cys Pro Tyr Val Cys His Leu Leu Tyr Leu Leu 
        195                 200                 205             


Thr Lys Lys Glu Asn Val Lys Pro Phe Arg Val Arg Lys Leu Leu Asp 
    210                 215                 220                 


Leu Gln Ala Lys Met Gly Met Gln Pro His Leu Gln Ala Leu Leu Ser 
225                 230                 235                 240 


Leu Tyr Lys Phe Phe Ala Pro Ala Leu Ile Ser Val Ser Leu Pro Val 
                245                 250                 255     


Arg Lys Lys Ile Tyr Phe Lys Asn Ser Glu Asn Leu Trp Lys Thr Ala 
            260                 265                 270         


Leu Leu Ala Val Lys Gln Arg Asn Arg Gly Pro Ser Pro Glu Pro Leu 
        275                 280                 285             


Lys Leu Met Leu Gly Pro Ala Asn Val Arg Pro Leu Lys Arg Lys Trp 
    290                 295                 300                 


Asn Ser Leu Ser Val Ile Pro Val Leu Asn Ser Ser Ser Tyr Thr Lys 
305                 310                 315                 320 


Glu Cys Gly Lys Lys Glu Met Ser Leu Ser Asp Cys Leu Asn Arg Ser 
                325                 330                 335     


Gly Ser Phe Pro Leu Glu Gln Leu Gln Ser Phe Pro Gln Leu Leu Gln 
            340                 345                 350         


Asn Ile His Cys Leu Glu Leu Pro Ser Gln Met Gly Ser Val Leu Asn 
        355                 360                 365             


Asn Ser Leu Leu Leu His Tyr Ile Asn Cys Val Arg Asp Glu Pro Val 
    370                 375                 380                 


Leu Leu Arg Phe Tyr Tyr Trp Leu Ser Gln Thr Leu Gln Glu Glu Cys 
385                 390                 395                 400 


Ile Trp Tyr Lys Val Asn Asn Tyr Glu His Gly Lys Glu Phe Thr Asn 
                405                 410                 415     


Phe Leu Asp Thr Ile Ile Arg Ala Glu Cys Phe Leu Gln Glu Gly Phe 
            420                 425                 430         


Tyr Ser Cys Glu Ala Phe Leu Tyr Lys Ser Leu Pro Leu Trp Asp Gly 
        435                 440                 445             


Leu Cys Cys Arg Ser Gln Phe Leu Gln Leu Val Ser Trp Ile Pro Phe 
    450                 455                 460                 


Ser Ser Phe Ser Glu Val Lys Pro Leu Leu Phe Asp His Leu Ala Gln 
465                 470                 475                 480 


Leu Phe Phe Thr Ser Thr Ile Tyr Phe Lys Cys Ser Val Leu Gln Ser 
                485                 490                 495     


Leu Lys Glu Leu Leu Gln Asn Trp Leu Leu Trp Leu Ser Met Asp Ile 
            500                 505                 510         


His Met Lys Pro Val Thr Asn Ser Pro Leu 
        515                 520         


<210> 6336
<211> 756
<212> PRT
<213> Homo sapiens

<400> 6336
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr 
1               5                   10                  15      


Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val 
            20                  25                  30          


Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His Gly Gln Asn 
        35                  40                  45              


Asn Pro Val Gly Asp Tyr Glu His Ala Asp Asp Gln Ala Glu Glu Asp 
    50                  55                  60                  


Ala Leu Gln Met Ala Val Gly Tyr Phe Glu Lys Gly Pro Ile Lys Ala 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Thr Leu Glu Lys His Leu Lys Thr Val Glu 
                85                  90                  95      


Asn Val Ala Trp Lys Asn Gly Leu Ala Ser Glu Glu Ile Asp Ile Leu 
            100                 105                 110         


Leu Asn Ile Ala Leu Ser Gly Lys Phe Gly Asn Ala Val Asn Thr Arg 
        115                 120                 125             


Ile Leu Lys Cys Met Ile Pro Ala Thr Val Ile Ser Glu Asp Ser Val 
    130                 135                 140                 


Val Lys Ala Val Ser Trp Leu Cys Val Gly Lys Cys Ser Gly Ser Thr 
145                 150                 155                 160 


Lys Val Leu Phe Tyr Arg Trp Leu Val Ala Met Phe Asp Phe Ile Asp 
                165                 170                 175     


Arg Lys Glu Gln Ile Asn Leu Leu Tyr Gly Phe Phe Phe Ala Ser Leu 
            180                 185                 190         


Gln Asp Asp Ala Leu Cys Pro Tyr Val Cys His Leu Leu Tyr Leu Leu 
        195                 200                 205             


Thr Lys Lys Glu Asn Val Lys Pro Phe Arg Val Arg Lys Leu Leu Asp 
    210                 215                 220                 


Leu Gln Ala Lys Met Gly Met Gln Pro His Leu Gln Ala Leu Leu Ser 
225                 230                 235                 240 


Leu Tyr Lys Phe Phe Ala Pro Ala Leu Ile Ser Val Ser Leu Pro Val 
                245                 250                 255     


Arg Lys Lys Ile Tyr Phe Lys Asn Ser Glu Asn Leu Trp Lys Thr Ala 
            260                 265                 270         


Leu Leu Ala Val Lys Gln Arg Asn Arg Gly Pro Ser Pro Glu Pro Leu 
        275                 280                 285             


Lys Leu Met Leu Gly Pro Ala Asn Val Arg Pro Leu Lys Arg Lys Trp 
    290                 295                 300                 


Asn Ser Leu Ser Val Ile Pro Val Leu Asn Ser Ser Ser Tyr Thr Lys 
305                 310                 315                 320 


Glu Cys Gly Lys Lys Glu Met Ser Leu Ser Asp Cys Leu Asn Arg Ser 
                325                 330                 335     


Gly Ser Phe Pro Leu Glu Gln Leu Gln Ser Phe Pro Gln Leu Leu Gln 
            340                 345                 350         


Asn Ile His Cys Leu Glu Leu Pro Ser Gln Met Gly Ser Val Leu Asn 
        355                 360                 365             


Asn Ser Leu Leu Leu His Tyr Ile Asn Cys Val Arg Asp Glu Pro Val 
    370                 375                 380                 


Leu Leu Arg Phe Tyr Tyr Trp Leu Ser Gln Thr Leu Gln Glu Glu Cys 
385                 390                 395                 400 


Ile Trp Tyr Lys Val Asn Asn Tyr Glu His Gly Lys Glu Phe Thr Asn 
                405                 410                 415     


Phe Leu Asp Thr Ile Ile Arg Ala Glu Cys Phe Leu Gln Glu Gly Phe 
            420                 425                 430         


Tyr Ser Cys Glu Ala Phe Leu Tyr Lys Ser Leu Pro Leu Trp Asp Gly 
        435                 440                 445             


Leu Cys Cys Arg Ser Gln Phe Leu Gln Leu Val Ser Trp Ile Pro Phe 
    450                 455                 460                 


Ser Ser Phe Ser Glu Val Lys Pro Leu Leu Phe Asp His Leu Ala Gln 
465                 470                 475                 480 


Leu Phe Phe Thr Ser Thr Ile Tyr Phe Lys Cys Ser Val Leu Gln Ser 
                485                 490                 495     


Leu Lys Glu Leu Leu Gln Asn Trp Leu Leu Trp Leu Ser Met Asp Ile 
            500                 505                 510         


His Met Lys Pro Val Thr Asn Ser Pro Leu Glu Thr Thr Leu Gly Gly 
        515                 520                 525             


Ser Met Asn Ser Val Ser Lys Leu Ile His Tyr Val Gly Trp Leu Ser 
    530                 535                 540                 


Thr Thr Ala Met Arg Leu Glu Ser Asn Asn Thr Phe Leu Leu His Phe 
545                 550                 555                 560 


Ile Leu Asp Phe Tyr Glu Lys Val Cys Asp Ile Tyr Ile Asn Tyr Asn 
                565                 570                 575     


Leu Pro Leu Val Val Leu Phe Pro Pro Gly Ile Phe Tyr Ser Ala Leu 
            580                 585                 590         


Leu Ser Leu Asp Thr Ser Ile Leu Asn Gln Leu Cys Phe Ile Met His 
        595                 600                 605             


Arg Tyr Arg Lys Asn Leu Thr Ala Ala Lys Lys Asn Glu Leu Val Gln 
    610                 615                 620                 


Lys Thr Lys Ser Glu Phe Asn Phe Ser Ser Lys Thr Tyr Gln Glu Phe 
625                 630                 635                 640 


Asn His Tyr Leu Thr Ser Met Val Gly Cys Leu Trp Thr Ser Lys Pro 
                645                 650                 655     


Phe Gly Lys Gly Ile Tyr Ile Asp Pro Glu Ile Leu Glu Lys Thr Gly 
            660                 665                 670         


Val Ala Glu Tyr Lys Asn Ser Leu Asn Val Val His His Pro Ser Phe 
        675                 680                 685             


Leu Ser Tyr Ala Val Ser Phe Leu Leu Gln Glu Ser Pro Glu Glu Arg 
    690                 695                 700                 


Thr Val Asn Val Ser Ser Ile Arg Gly Lys Lys Trp Ser Trp Tyr Leu 
705                 710                 715                 720 


Asp Tyr Leu Phe Ser Gln Gly Leu Gln Gly Leu Lys Leu Phe Ile Arg 
                725                 730                 735     


Ser Ser Val His His Ser Ser Ile Pro Arg Ala Glu Gly Ile Asn Cys 
            740                 745                 750         


Asn Asn Gln Tyr 
        755     


<210> 6337
<211> 310
<212> PRT
<213> Homo sapiens

<400> 6337
Met Ala Asp Ala Ala Ala Thr Ala Gly Ala Gly Gly Ser Gly Thr Arg 
1               5                   10                  15      


Ser Gly Ser Lys Gln Ser Thr Asn Pro Ala Asp Asn Tyr His Leu Ala 
            20                  25                  30          


Arg Arg Arg Thr Leu Gln Val Val Val Ser Ser Leu Leu Thr Glu Ala 
        35                  40                  45              


Gly Phe Glu Ser Ala Glu Lys Ala Ser Val Glu Thr Leu Thr Glu Met 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Ser Glu Ile Gly Arg Ser Ala Lys Ser Tyr Cys 
65                  70                  75                  80  


Glu His Thr Ala Arg Thr Gln Pro Thr Leu Ser Asp Ile Val Val Thr 
                85                  90                  95      


Leu Val Glu Met Gly Phe Asn Val Asp Thr Leu Pro Ala Tyr Ala Lys 
            100                 105                 110         


Arg Ser Gln Arg Met Val Ile Thr Ala Pro Pro Val Thr Asn Gln Pro 
        115                 120                 125             


Val Thr Pro Lys Ala Leu Thr Ala Gly Gln Asn Arg Pro His Pro Pro 
    130                 135                 140                 


His Ile Pro Ser His Phe Pro Glu Phe Pro Asp Pro His Thr Tyr Ile 
145                 150                 155                 160 


Lys Thr Pro Thr Tyr Arg Glu Pro Val Ser Asp Tyr Gln Val Leu Arg 
                165                 170                 175     


Glu Lys Ala Ala Ser Gln Arg Arg Asp Val Glu Arg Ala Leu Thr Arg 
            180                 185                 190         


Phe Met Ala Lys Thr Gly Glu Thr Gln Ser Leu Phe Lys Asp Asp Val 
        195                 200                 205             


Ser Thr Phe Pro Leu Ile Ala Ala Arg Pro Phe Thr Ile Pro Tyr Leu 
    210                 215                 220                 


Thr Ala Leu Leu Pro Ser Glu Leu Glu Met Gln Gln Met Glu Glu Thr 
225                 230                 235                 240 


Asp Ser Ser Glu Gln Asp Glu Gln Thr Asp Thr Glu Asn Leu Ala Leu 
                245                 250                 255     


His Ile Ser Met Glu Asp Ser Gly Ala Glu Lys Glu Asn Thr Ser Val 
            260                 265                 270         


Leu Gln Gln Asn Pro Ser Leu Ser Gly Ser Arg Asn Gly Glu Glu Asn 
        275                 280                 285             


Ile Ile Asp Asn Pro Tyr Leu Arg Pro Val Lys Lys Pro Lys Ile Arg 
    290                 295                 300                 


Arg Lys Lys Ser Leu Ser 
305                 310 


<210> 6338
<211> 644
<212> PRT
<213> Homo sapiens

<400> 6338
Met Glu Glu Thr Met Lys Leu Ala Thr Met Glu Asp Thr Val Glu Tyr 
1               5                   10                  15      


Cys Leu Phe Leu Ile Pro Asp Glu Ser Arg Asp Ser Asp Lys His Lys 
            20                  25                  30          


Glu Ile Leu Gln Lys Tyr Ile Glu Arg Ile Ile Thr Arg Phe Ala Pro 
        35                  40                  45              


Met Leu Val Pro Tyr Ile Trp Gln Asn Gln Pro Phe Asn Leu Lys Tyr 
    50                  55                  60                  


Lys Pro Gly Lys Gly Gly Val Pro Ala His Met Phe Gly Val Thr Lys 
65                  70                  75                  80  


Phe Gly Asp Asn Ile Glu Asp Glu Trp Phe Ile Val Tyr Val Ile Lys 
                85                  90                  95      


Gln Ile Thr Lys Glu Phe Pro Glu Leu Val Ala Arg Ile Glu Asp Asn 
            100                 105                 110         


Asp Gly Glu Phe Leu Leu Ile Glu Ala Ala Asp Phe Leu Pro Lys Trp 
        115                 120                 125             


Leu Asp Pro Glu Asn Ser Thr Asn Arg Val Phe Phe Cys His Gly Glu 
    130                 135                 140                 


Leu Cys Ile Ile Pro Ala Pro Arg Lys Ser Gly Ala Glu Ser Trp Leu 
145                 150                 155                 160 


Pro Thr Thr Pro Pro Thr Ile Pro Gln Ala Leu Asn Ile Ile Thr Ala 
                165                 170                 175     


His Ser Glu Lys Ile Leu Ala Ser Glu Ser Ile Arg Ala Ala Val Asn 
            180                 185                 190         


Arg Arg Ile Arg Gly Tyr Pro Glu Lys Ile Gln Ala Ser Leu His Arg 
        195                 200                 205             


Ala His Cys Phe Leu Pro Ala Gly Ile Val Ala Val Leu Lys Gln Arg 
    210                 215                 220                 


Pro Arg Leu Val Ala Ala Ala Val Gln Ala Phe Tyr Leu Arg Asp Pro 
225                 230                 235                 240 


Ile Asp Leu Arg Ala Cys Arg Val Phe Lys Thr Phe Leu Pro Glu Thr 
                245                 250                 255     


Arg Ile Met Thr Ser Val Thr Phe Thr Lys Cys Leu Tyr Ala Gln Leu 
            260                 265                 270         


Val Gln Gln Arg Phe Val Pro Asp Arg Arg Ser Gly Tyr Arg Leu Pro 
        275                 280                 285             


Pro Pro Ser Asp Pro Gln Tyr Arg Ala His Glu Leu Gly Met Lys Leu 
    290                 295                 300                 


Ala His Gly Phe Glu Ile Leu Cys Ser Lys Cys Ser Pro His Phe Ser 
305                 310                 315                 320 


Asp Cys Lys Lys Ser Leu Val Thr Ala Ser Pro Leu Trp Ala Ser Phe 
                325                 330                 335     


Leu Glu Ser Leu Lys Lys Asn Asp Tyr Phe Lys Gly Leu Ile Glu Gly 
            340                 345                 350         


Ser Ala Gln Tyr Arg Glu Arg Leu Glu Met Ala Glu Asn Tyr Phe Gln 
        355                 360                 365             


Leu Ser Val Asp Trp Pro Glu Ser Ser Leu Ala Met Ser Pro Gly Glu 
    370                 375                 380                 


Glu Ile Leu Thr Leu Leu Gln Thr Ile Pro Phe Asp Ile Glu Asp Leu 
385                 390                 395                 400 


Lys Lys Glu Ala Ala Asn Leu Pro Pro Glu Asp Asp Asp Gln Trp Leu 
                405                 410                 415     


Asp Leu Ser Pro Asp Gln Leu Asp Gln Leu Leu Gln Glu Ala Val Gly 
            420                 425                 430         


Lys Lys Glu Ser Glu Ser Val Ser Lys Glu Glu Lys Glu Gln Asn Tyr 
        435                 440                 445             


Asp Leu Thr Glu Val Ser Glu Ser Met Lys Ala Phe Ile Ser Lys Val 
    450                 455                 460                 


Ser Thr His Lys Gly Ala Glu Leu Pro Arg Glu Pro Ser Glu Ala Pro 
465                 470                 475                 480 


Ile Thr Phe Asp Ala Asp Ser Phe Leu Asn Tyr Phe Asp Lys Ile Leu 
                485                 490                 495     


Gly Pro Arg Pro Asn Glu Ser Asp Ser Asp Asp Leu Asp Asp Glu Asp 
            500                 505                 510         


Phe Glu Cys Leu Asp Ser Asp Asp Asp Leu Asp Phe Glu Thr His Glu 
        515                 520                 525             


Pro Gly Glu Glu Ala Ser Leu Lys Gly Thr Leu Asp Asn Leu Lys Ser 
    530                 535                 540                 


Tyr Met Ala Gln Met Asp Gln Glu Leu Ala His Thr Cys Ile Ser Lys 
545                 550                 555                 560 


Ser Phe Thr Thr Arg Asn Gln Val Glu Pro Val Ser Gln Thr Thr Asp 
                565                 570                 575     


Asn Asn Ser Asp Glu Glu Asp Ser Gly Thr Gly Glu Ser Val Met Ala 
            580                 585                 590         


Pro Val Asp Val Asp Leu Asn Leu Val Ser Asn Ile Leu Glu Ser Tyr 
        595                 600                 605             


Ser Ser Gln Ala Gly Leu Ala Gly Pro Ala Ser Asn Leu Leu Gln Ser 
    610                 615                 620                 


Met Gly Val Gln Leu Pro Asp Asn Thr Asp His Arg Pro Thr Ser Lys 
625                 630                 635                 640 


Pro Thr Lys Asn 
                


<210> 6339
<211> 720
<212> PRT
<213> Homo sapiens

<400> 6339
Met Ser Val Ser Gly Lys Lys Glu Phe Asp Val Lys Gln Ile Leu Arg 
1               5                   10                  15      


Leu Arg Trp Arg Trp Phe Ser His Pro Phe Gln Gly Ser Thr Asn Thr 
            20                  25                  30          


Gly Ser Cys Leu Gln Gln Glu Gly Tyr Glu His Arg Gly Thr Pro Val 
        35                  40                  45              


Gln Gly Arg Leu Lys Ser His Ser Arg Asp Arg Asn Gly Leu Lys Lys 
    50                  55                  60                  


Ser Asn Ser Pro Val His His Asn Ile Leu Ala Pro Val Pro Gly Pro 
65                  70                  75                  80  


Ala Pro Ala His Gln Arg Ala Val Gln Asn Leu Gln Gln His Asn Leu 
                85                  90                  95      


Ile Val His Phe Gln Ala Asn Glu Asp Thr Pro Lys Ser Val Pro Glu 
            100                 105                 110         


Lys Asn Leu Phe Lys Glu Ala Cys Glu Lys Arg Ala Gln Asp Leu Glu 
        115                 120                 125             


Met Met Ala Asp Asp Asn Ile Glu Asp Ser Thr Ala Arg Leu Asp Thr 
    130                 135                 140                 


Gln His Ser Glu Asp Met Asn Ala Thr Arg Ser Glu Glu Gln Phe His 
145                 150                 155                 160 


Val Ile Asn His Ala Glu Gln Thr Leu Arg Lys Met Glu Asn Tyr Leu 
                165                 170                 175     


Lys Glu Lys Gln Leu Cys Asp Val Leu Leu Ile Ala Gly His Leu Arg 
            180                 185                 190         


Ile Pro Ala His Arg Leu Val Leu Ser Ala Val Ser Asp Tyr Phe Ala 
        195                 200                 205             


Ala Met Phe Thr Asn Asp Val Leu Glu Ala Lys Gln Glu Glu Val Arg 
    210                 215                 220                 


Met Glu Gly Val Asp Pro Asn Ala Leu Asn Ser Leu Val Gln Tyr Ala 
225                 230                 235                 240 


Tyr Thr Gly Val Leu Gln Leu Lys Glu Asp Thr Ile Glu Ser Leu Leu 
                245                 250                 255     


Ala Ala Ala Cys Leu Leu Gln Leu Thr Gln Val Ile Asp Val Cys Ser 
            260                 265                 270         


Asn Phe Leu Ile Lys Gln Leu His Pro Ser Asn Cys Leu Gly Ile Arg 
        275                 280                 285             


Ser Phe Gly Asp Ala Gln Gly Cys Thr Glu Leu Leu Asn Val Ala His 
    290                 295                 300                 


Lys Tyr Thr Met Glu His Phe Ile Glu Val Ile Lys Asn Gln Glu Phe 
305                 310                 315                 320 


Leu Leu Leu Pro Ala Asn Glu Ile Ser Lys Leu Leu Cys Ser Asp Asp 
                325                 330                 335     


Ile Asn Val Pro Asp Glu Glu Thr Ile Phe His Ala Leu Met Gln Trp 
            340                 345                 350         


Val Gly His Asp Val Gln Asn Arg Gln Gly Glu Leu Gly Met Leu Leu 
        355                 360                 365             


Ser Tyr Ile Arg Leu Pro Leu Leu Pro Pro Gln Leu Leu Ala Asp Leu 
    370                 375                 380                 


Glu Thr Ser Ser Met Phe Thr Gly Asp Leu Glu Cys Gln Lys Leu Leu 
385                 390                 395                 400 


Met Glu Ala Met Lys Tyr His Leu Leu Pro Glu Arg Arg Ser Met Met 
                405                 410                 415     


Gln Ser Pro Arg Thr Lys Pro Arg Lys Ser Thr Val Gly Ala Leu Tyr 
            420                 425                 430         


Ala Val Gly Gly Met Asp Ala Met Lys Gly Thr Thr Thr Ile Glu Lys 
        435                 440                 445             


Tyr Asp Leu Arg Thr Asn Ser Trp Leu His Ile Gly Thr Met Asn Gly 
    450                 455                 460                 


Arg Arg Leu Gln Phe Gly Val Ala Val Ile Asp Asn Lys Leu Tyr Val 
465                 470                 475                 480 


Val Gly Gly Arg Asp Gly Leu Lys Thr Leu Asn Thr Val Glu Cys Phe 
                485                 490                 495     


Asn Pro Val Gly Lys Ile Trp Thr Val Met Pro Pro Met Ser Thr His 
            500                 505                 510         


Arg His Gly Leu Gly Val Ala Thr Leu Glu Gly Pro Met Tyr Ala Val 
        515                 520                 525             


Gly Gly His Asp Gly Trp Ser Tyr Leu Asn Thr Val Glu Arg Trp Asp 
    530                 535                 540                 


Pro Glu Gly Arg Gln Trp Asn Tyr Val Ala Ser Met Ser Thr Pro Arg 
545                 550                 555                 560 


Ser Thr Val Gly Val Val Ala Leu Asn Asn Lys Leu Tyr Ala Ile Gly 
                565                 570                 575     


Gly Arg Asp Gly Ser Ser Cys Leu Lys Ser Met Glu Tyr Phe Asp Pro 
            580                 585                 590         


His Thr Asn Lys Trp Ser Leu Cys Ala Pro Met Ser Lys Arg Arg Gly 
        595                 600                 605             


Gly Val Gly Val Ala Thr Tyr Asn Gly Phe Leu Tyr Val Val Gly Gly 
    610                 615                 620                 


His Asp Ala Pro Ala Ser Asn His Cys Ser Arg Leu Ser Asp Cys Val 
625                 630                 635                 640 


Glu Arg Tyr Asp Pro Lys Gly Asp Ser Trp Ser Thr Val Ala Pro Leu 
                645                 650                 655     


Ser Val Pro Arg Asp Ala Val Ala Val Cys Pro Leu Gly Asp Lys Leu 
            660                 665                 670         


Tyr Val Val Gly Gly Tyr Asp Gly His Thr Tyr Leu Asn Thr Val Glu 
        675                 680                 685             


Ser Tyr Asp Ala Gln Arg Asn Glu Trp Lys Glu Ser Met Gln Glu Leu 
    690                 695                 700                 


Leu Gln Asn Phe Tyr Thr Thr Gln Lys Leu Lys Glu Thr Leu Gly His 
705                 710                 715                 720 


<210> 6340
<211> 718
<212> PRT
<213> Homo sapiens

<400> 6340
Met Ser Val Ser Gly Lys Lys Glu Phe Asp Val Lys Gln Ile Leu Arg 
1               5                   10                  15      


Leu Arg Trp Arg Trp Phe Ser His Pro Phe Gln Gly Ser Thr Asn Thr 
            20                  25                  30          


Gly Ser Cys Leu Gln Gln Glu Gly Tyr Glu His Arg Gly Thr Pro Val 
        35                  40                  45              


Gln Gly Arg Leu Lys Ser His Ser Arg Asp Arg Asn Gly Leu Lys Lys 
    50                  55                  60                  


Ser Asn Ser Pro Val His His Asn Ile Leu Ala Pro Val Pro Gly Pro 
65                  70                  75                  80  


Ala Pro Ala His Gln Arg Ala Val Gln Asn Leu Gln Gln His Asn Leu 
                85                  90                  95      


Ile Val His Phe Gln Ala Asn Glu Asp Thr Pro Lys Ser Val Pro Glu 
            100                 105                 110         


Lys Asn Leu Phe Lys Glu Ala Cys Glu Lys Arg Ala Gln Asp Leu Glu 
        115                 120                 125             


Met Met Ala Asp Asp Asn Ile Glu Asp Ser Thr Ala Arg Leu Asp Thr 
    130                 135                 140                 


Gln His Ser Glu Asp Met Asn Ala Thr Arg Ser Glu Glu Gln Phe His 
145                 150                 155                 160 


Val Ile Asn His Ala Glu Gln Thr Leu Arg Lys Met Glu Asn Tyr Leu 
                165                 170                 175     


Lys Glu Lys Gln Leu Cys Asp Val Leu Leu Ile Ala Gly His Leu Arg 
            180                 185                 190         


Ile Pro Ala His Arg Leu Val Leu Ser Ala Val Ser Asp Tyr Phe Ala 
        195                 200                 205             


Ala Met Phe Thr Asn Asp Val Leu Glu Ala Lys Gln Glu Glu Val Arg 
    210                 215                 220                 


Met Glu Gly Val Asp Pro Asn Ala Leu Asn Ser Leu Val Gln Tyr Ala 
225                 230                 235                 240 


Tyr Thr Gly Val Leu Gln Leu Lys Glu Asp Thr Ile Glu Ser Leu Leu 
                245                 250                 255     


Ala Ala Ala Cys Leu Leu Gln Leu Thr Gln Val Ile Asp Val Cys Ser 
            260                 265                 270         


Asn Phe Leu Ile Lys Gln Leu His Pro Ser Asn Cys Leu Gly Ile Arg 
        275                 280                 285             


Ser Phe Gly Asp Ala Gln Gly Cys Thr Glu Leu Leu Asn Val Ala His 
    290                 295                 300                 


Lys Tyr Thr Met Glu His Phe Ile Glu Val Ile Lys Asn Gln Glu Phe 
305                 310                 315                 320 


Leu Leu Leu Pro Ala Asn Glu Ile Ser Lys Leu Leu Cys Ser Asp Asp 
                325                 330                 335     


Ile Asn Val Pro Asp Glu Glu Thr Ile Phe His Ala Leu Met Gln Trp 
            340                 345                 350         


Val Gly His Asp Val Gln Asn Arg Gln Gly Glu Leu Gly Met Leu Leu 
        355                 360                 365             


Ser Tyr Ile Arg Leu Pro Leu Leu Pro Pro Gln Leu Leu Ala Asp Leu 
    370                 375                 380                 


Glu Thr Ser Ser Met Phe Thr Gly Asp Leu Glu Cys Gln Lys Leu Leu 
385                 390                 395                 400 


Met Glu Ala Met Lys Tyr His Leu Leu Pro Glu Arg Arg Ser Met Met 
                405                 410                 415     


Gln Ser Pro Arg Thr Lys Pro Arg Lys Ser Thr Val Gly Ala Leu Tyr 
            420                 425                 430         


Ala Val Gly Gly Met Asp Ala Met Lys Gly Thr Thr Thr Ile Glu Lys 
        435                 440                 445             


Tyr Asp Leu Arg Thr Asn Ser Trp Leu His Ile Gly Thr Met Asn Gly 
    450                 455                 460                 


Arg Arg Leu Gln Phe Gly Val Ala Val Ile Asp Asn Lys Leu Tyr Val 
465                 470                 475                 480 


Val Gly Gly Arg Asp Gly Leu Lys Thr Leu Asn Thr Val Glu Cys Phe 
                485                 490                 495     


Asn Pro Val Gly Lys Ile Trp Thr Val Met Pro Pro Met Ser Thr His 
            500                 505                 510         


Arg His Gly Leu Gly Val Ala Thr Leu Glu Gly Pro Met Tyr Ala Val 
        515                 520                 525             


Gly Gly His Asp Gly Trp Ser Tyr Leu Asn Thr Val Glu Arg Trp Asp 
    530                 535                 540                 


Pro Glu Gly Arg Gln Trp Asn Tyr Val Ala Ser Met Ser Thr Pro Arg 
545                 550                 555                 560 


Ser Thr Val Gly Val Val Ala Leu Asn Asn Lys Leu Tyr Ala Ile Gly 
                565                 570                 575     


Gly Arg Asp Gly Ser Ser Cys Leu Lys Ser Met Glu Tyr Phe Asp Pro 
            580                 585                 590         


His Thr Asn Lys Trp Ser Leu Cys Ala Pro Met Ser Lys Arg Arg Gly 
        595                 600                 605             


Gly Val Gly Val Ala Thr Tyr Asn Gly Phe Leu Tyr Val Val Gly Gly 
    610                 615                 620                 


His Asp Ala Pro Ala Ser Asn His Cys Ser Arg Leu Ser Asp Cys Val 
625                 630                 635                 640 


Glu Arg Tyr Asp Pro Lys Gly Asp Ser Trp Ser Thr Val Ala Pro Leu 
                645                 650                 655     


Ser Val Pro Arg Asp Ala Val Ala Val Cys Pro Leu Gly Asp Lys Leu 
            660                 665                 670         


Tyr Val Val Gly Gly Tyr Asp Gly His Thr Tyr Leu Asn Thr Val Glu 
        675                 680                 685             


Ser Tyr Asp Ala Gln Arg Asn Glu Trp Lys Glu Glu Val Pro Val Asn 
    690                 695                 700                 


Ile Gly Arg Ala Gly Ala Cys Val Val Val Val Lys Leu Pro 
705                 710                 715             


<210> 6341
<211> 377
<212> PRT
<213> Homo sapiens

<400> 6341
Met Asn Gly Pro Val Ser Pro Lys Ser Lys Ala Arg Pro Ser Ser Pro 
1               5                   10                  15      


Ser Thr Ser Trp His Arg Pro Ala Ser Pro Cys Pro Ser Pro Gly Pro 
            20                  25                  30          


Gly His Thr Leu Pro Pro Lys Pro Pro Ser Pro Arg Gly Thr Thr Ala 
        35                  40                  45              


Ser Pro Lys Gly Arg Val Arg Arg Lys Glu Glu Ala Lys Glu Ser Pro 
    50                  55                  60                  


Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln Ser Lys Arg Arg Ala Ser 
65                  70                  75                  80  


Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser Pro Ala Pro Ser Pro Ala 
                85                  90                  95      


Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys Glu Gln Pro Pro Ala Glu 
            100                 105                 110         


Thr Pro Thr Ala Pro Ala Pro Pro Val Thr Pro Ser Lys Pro Met Ala 
        115                 120                 125             


Gly Thr Thr Asp Arg Glu Glu Ala Thr Arg Leu Leu Ala Glu Lys Arg 
    130                 135                 140                 


Arg Gln Ala Arg Glu Gln Arg Glu Arg Glu Glu Gln Glu Arg Arg Leu 
145                 150                 155                 160 


Gln Ala Glu Arg Asp Lys Arg Met Arg Glu Glu Gln Leu Ala Arg Glu 
                165                 170                 175     


Ala Glu Ala Arg Ala Glu Arg Glu Ala Glu Ala Arg Arg Arg Glu Glu 
            180                 185                 190         


Gln Glu Ala Arg Glu Lys Ala Gln Ala Glu Gln Glu Glu Gln Glu Arg 
        195                 200                 205             


Leu Gln Lys Gln Lys Glu Glu Ala Glu Ala Arg Ser Arg Glu Glu Ala 
    210                 215                 220                 


Glu Arg Gln Arg Leu Glu Arg Glu Lys His Phe Gln Gln Gln Glu Gln 
225                 230                 235                 240 


Glu Arg Gln Glu Arg Arg Lys Arg Leu Glu Glu Ile Met Lys Arg Thr 
                245                 250                 255     


Arg Lys Ser Glu Val Ser Glu Thr Lys Lys Gln Asp Ser Lys Glu Ala 
            260                 265                 270         


Asn Ala Asn Gly Ser Ser Pro Glu Pro Val Lys Ala Val Glu Ala Arg 
        275                 280                 285             


Ser Pro Gly Leu Gln Lys Glu Ala Val Gln Lys Glu Glu Pro Ile Pro 
    290                 295                 300                 


Gln Glu Pro Gln Trp Ser Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu 
305                 310                 315                 320 


Val Asn Gly Leu Gln Pro Leu Pro Ala His Gln Glu Asn Gly Phe Ser 
                325                 330                 335     


Thr Asn Gly Pro Ser Gly Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr 
            340                 345                 350         


Leu Leu Pro Phe Ala Glu Ala Glu Ala Phe Leu Lys Lys Ala Val Val 
        355                 360                 365             


Gln Ser Pro Gln Val Thr Glu Val Leu 
    370                 375         


<210> 6342
<211> 808
<212> PRT
<213> Homo sapiens

<400> 6342
Met Glu Ser Gly Pro Arg Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala 
1               5                   10                  15      


Val Val Ala Arg Thr Pro Pro Glu Pro Arg Pro Ser Pro Glu Gly Asp 
            20                  25                  30          


Pro Ser Pro Pro Pro Pro Pro Met Ser Ala Leu Val Pro Asp Thr Pro 
        35                  40                  45              


Pro Asp Thr Pro Pro Ala Met Lys Asn Ala Thr Ser Ser Lys Gln Leu 
    50                  55                  60                  


Pro Leu Glu Pro Glu Ser Pro Ser Gly Gln Val Gly Pro Arg Pro Ala 
65                  70                  75                  80  


Pro Pro Gln Glu Glu Ser Pro Ser Ser Glu Ala Lys Ser Arg Gly Pro 
                85                  90                  95      


Thr Pro Pro Ala Met Gly Pro Arg Asp Ala Arg Pro Pro Arg Arg Ser 
            100                 105                 110         


Ser Gln Pro Ser Pro Thr Ala Val Pro Ala Ser Asp Ser Pro Pro Thr 
        115                 120                 125             


Lys Gln Glu Val Lys Lys Ala Gly Glu Arg His Lys Leu Ala Lys Glu 
    130                 135                 140                 


Arg Arg Glu Glu Arg Ala Lys Tyr Leu Ala Ala Lys Lys Ala Val Trp 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Lys Ala Lys Ala Leu Arg Glu Lys Gln Leu Gln 
                165                 170                 175     


Glu Arg Arg Arg Arg Leu Glu Glu Gln Arg Leu Lys Ala Glu Gln Arg 
            180                 185                 190         


Arg Ala Ala Leu Glu Glu Arg Gln Arg Gln Lys Leu Glu Lys Asn Lys 
        195                 200                 205             


Glu Arg Tyr Glu Ala Ala Ile Gln Arg Ser Val Lys Lys Thr Trp Ala 
    210                 215                 220                 


Glu Ile Arg Gln Gln Arg Trp Ser Trp Ala Gly Ala Leu His His Ser 
225                 230                 235                 240 


Ser Pro Gly His Lys Thr Ser Gly Ser Arg Cys Ser Val Ser Ala Val 
                245                 250                 255     


Asn Leu Pro Lys His Val Asp Ser Ile Ile Asn Lys Arg Leu Ser Lys 
            260                 265                 270         


Ser Ser Ala Thr Leu Trp Asn Ser Pro Ser Arg Asn Arg Ser Leu Gln 
        275                 280                 285             


Leu Ser Ala Trp Glu Ser Ser Ile Val Asp Arg Leu Met Thr Pro Thr 
    290                 295                 300                 


Leu Ser Phe Leu Ala Arg Ser Arg Ser Ala Val Thr Leu Pro Arg Asn 
305                 310                 315                 320 


Gly Arg Asp Gln Ala Val Pro Val Cys Pro Arg Ser Ala Ser Ala Ser 
                325                 330                 335     


Pro Leu Thr Pro Cys Ser Val Thr Arg Ser Val His Arg Cys Ala Pro 
            340                 345                 350         


Ala Gly Glu Arg Gly Glu Arg Arg Lys Pro Asn Ala Gly Gly Ser Pro 
        355                 360                 365             


Ala Pro Val Arg Arg Arg Pro Glu Ala Ser Pro Val Gln Lys Lys Glu 
    370                 375                 380                 


Lys Lys Asp Lys Glu Arg Glu Asn Glu Lys Glu Lys Ser Ala Leu Ala 
385                 390                 395                 400 


Arg Glu Arg Ser Leu Lys Lys Arg Gln Ser Leu Pro Ala Ser Pro Arg 
                405                 410                 415     


Ala Arg Leu Ser Ala Ser Thr Ala Ser Glu Leu Ser Pro Lys Ser Lys 
            420                 425                 430         


Ala Arg Pro Ser Ser Pro Ser Thr Ser Trp His Arg Pro Ala Ser Pro 
        435                 440                 445             


Cys Pro Ser Pro Gly Pro Gly His Thr Leu Pro Pro Lys Pro Pro Ser 
    450                 455                 460                 


Pro Arg Gly Thr Thr Ala Ser Pro Lys Gly Arg Val Arg Arg Lys Glu 
465                 470                 475                 480 


Glu Ala Lys Glu Ser Pro Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln 
                485                 490                 495     


Ser Lys Arg Arg Ala Ser Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser 
            500                 505                 510         


Pro Ala Pro Ser Pro Ala Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys 
        515                 520                 525             


Glu Gln Pro Pro Ala Glu Thr Pro Thr Asp Ala Ala Val Leu Thr Ser 
    530                 535                 540                 


Pro Pro Ala Pro Ala Pro Pro Val Thr Pro Ser Lys Pro Met Ala Gly 
545                 550                 555                 560 


Thr Thr Asp Arg Glu Glu Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg 
                565                 570                 575     


Gln Ala Arg Glu Gln Arg Glu Arg Glu Glu Gln Glu Arg Arg Leu Gln 
            580                 585                 590         


Ala Glu Arg Asp Lys Arg Met Arg Glu Glu Gln Leu Ala Arg Glu Ala 
        595                 600                 605             


Glu Ala Arg Ala Glu Arg Glu Ala Glu Ala Arg Arg Arg Glu Glu Gln 
    610                 615                 620                 


Glu Ala Arg Glu Lys Ala Gln Ala Glu Gln Glu Glu Gln Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Gln Lys Glu Glu Ala Glu Ala Arg Ser Arg Glu Glu Ala Glu 
                645                 650                 655     


Arg Gln Arg Leu Glu Arg Glu Lys His Phe Gln Gln Gln Glu Gln Glu 
            660                 665                 670         


Arg Gln Glu Arg Arg Lys Arg Leu Glu Glu Ile Met Lys Arg Thr Arg 
        675                 680                 685             


Lys Ser Glu Val Ser Glu Thr Lys Lys Gln Asp Ser Lys Glu Ala Asn 
    690                 695                 700                 


Ala Asn Gly Ser Ser Pro Glu Pro Val Lys Ala Val Glu Ala Arg Ser 
705                 710                 715                 720 


Pro Gly Leu Gln Lys Glu Ala Val Gln Lys Glu Glu Pro Ile Pro Gln 
                725                 730                 735     


Glu Pro Gln Trp Ser Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu Val 
            740                 745                 750         


Asn Gly Leu Gln Pro Leu Pro Ala His Gln Glu Asn Gly Phe Ser Thr 
        755                 760                 765             


Asn Gly Pro Ser Gly Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr Leu 
    770                 775                 780                 


Leu Pro Phe Ala Glu Ala Glu Ala Phe Leu Lys Lys Ala Val Val Gln 
785                 790                 795                 800 


Ser Pro Gln Val Thr Glu Val Leu 
                805             


<210> 6343
<211> 841
<212> PRT
<213> Homo sapiens

<400> 6343
Met Glu Ser Gly Pro Arg Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala 
1               5                   10                  15      


Val Val Ala Arg Thr Pro Pro Glu Pro Arg Pro Ser Pro Glu Gly Asp 
            20                  25                  30          


Pro Ser Pro Pro Pro Pro Pro Met Ser Ala Leu Val Pro Asp Thr Pro 
        35                  40                  45              


Pro Asp Thr Pro Pro Ala Met Lys Asn Ala Thr Ser Ser Lys Gln Leu 
    50                  55                  60                  


Pro Leu Glu Pro Glu Ser Pro Ser Gly Gln Val Gly Pro Arg Pro Ala 
65                  70                  75                  80  


Pro Pro Gln Glu Glu Ser Pro Ser Ser Glu Ala Lys Ser Arg Gly Pro 
                85                  90                  95      


Thr Pro Pro Ala Met Gly Pro Arg Asp Ala Arg Pro Pro Arg Arg Ser 
            100                 105                 110         


Ser Gln Pro Ser Pro Thr Ala Val Pro Ala Ser Asp Ser Pro Pro Thr 
        115                 120                 125             


Lys Gln Glu Val Lys Lys Ala Gly Glu Arg His Lys Leu Ala Lys Glu 
    130                 135                 140                 


Arg Arg Glu Glu Arg Ala Lys Tyr Leu Ala Ala Lys Lys Ala Val Trp 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Lys Ala Lys Ala Leu Arg Glu Lys Gln Leu Gln 
                165                 170                 175     


Glu Arg Arg Arg Arg Leu Glu Glu Gln Arg Leu Lys Ala Glu Gln Arg 
            180                 185                 190         


Arg Ala Ala Leu Glu Glu Arg Gln Arg Gln Lys Leu Glu Lys Asn Lys 
        195                 200                 205             


Glu Arg Tyr Glu Ala Ala Ile Gln Arg Ser Val Lys Lys Thr Trp Ala 
    210                 215                 220                 


Glu Ile Arg Gln Gln Arg Trp Ser Trp Ala Gly Ala Leu His His Ser 
225                 230                 235                 240 


Ser Pro Gly His Lys Thr Ser Gly Ser Arg Cys Ser Val Ser Ala Val 
                245                 250                 255     


Asn Leu Pro Lys His Val Asp Ser Ile Ile Asn Lys Arg Leu Ser Lys 
            260                 265                 270         


Ser Ser Ala Thr Leu Trp Asn Ser Pro Ser Arg Asn Arg Ser Leu Gln 
        275                 280                 285             


Leu Ser Ala Trp Glu Ser Ser Ile Val Asp Arg Leu Met Thr Pro Thr 
    290                 295                 300                 


Leu Ser Phe Leu Ala Arg Ser Arg Ser Ala Val Thr Leu Pro Arg Asn 
305                 310                 315                 320 


Gly Arg Asp Gln Gly Arg Gly Cys Asp Pro Gly Arg Gly Pro Thr Trp 
                325                 330                 335     


Gly Arg Ala Gly Ala Ser Leu Ala Arg Gly Pro Gln Pro Asp Arg Thr 
            340                 345                 350         


His Pro Ser Ala Ala Val Pro Val Cys Pro Arg Ser Ala Ser Ala Ser 
        355                 360                 365             


Pro Leu Thr Pro Cys Ser Val Thr Arg Ser Val His Arg Cys Ala Pro 
    370                 375                 380                 


Ala Gly Glu Arg Gly Glu Arg Arg Lys Pro Asn Ala Gly Gly Ser Pro 
385                 390                 395                 400 


Ala Pro Val Arg Arg Arg Pro Glu Ala Ser Pro Val Gln Lys Lys Glu 
                405                 410                 415     


Lys Lys Asp Lys Glu Arg Glu Asn Glu Lys Glu Lys Ser Ala Leu Ala 
            420                 425                 430         


Arg Glu Arg Ser Leu Lys Lys Arg Gln Ser Leu Pro Ala Ser Pro Arg 
        435                 440                 445             


Ala Arg Leu Ser Ala Ser Thr Ala Ser Glu Leu Ser Pro Lys Ser Lys 
    450                 455                 460                 


Ala Arg Pro Ser Ser Pro Ser Thr Ser Trp His Arg Pro Ala Ser Pro 
465                 470                 475                 480 


Cys Pro Ser Pro Gly Pro Gly His Thr Leu Pro Pro Lys Pro Pro Ser 
                485                 490                 495     


Pro Arg Gly Thr Thr Ala Ser Pro Lys Gly Arg Val Arg Arg Lys Glu 
            500                 505                 510         


Glu Ala Lys Glu Ser Pro Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln 
        515                 520                 525             


Ser Lys Arg Arg Ala Ser Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser 
    530                 535                 540                 


Pro Ala Pro Ser Pro Ala Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys 
545                 550                 555                 560 


Glu Gln Pro Pro Ala Glu Thr Pro Thr Asp Ala Ala Val Leu Thr Ser 
                565                 570                 575     


Pro Pro Ala Pro Ala Pro Pro Val Thr Pro Ser Lys Pro Met Ala Gly 
            580                 585                 590         


Thr Thr Asp Arg Glu Glu Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg 
        595                 600                 605             


Gln Ala Arg Glu Gln Arg Glu Arg Glu Glu Gln Glu Arg Arg Leu Gln 
    610                 615                 620                 


Ala Glu Arg Asp Lys Arg Met Arg Glu Glu Gln Leu Ala Arg Glu Ala 
625                 630                 635                 640 


Glu Ala Arg Ala Glu Arg Glu Ala Glu Ala Arg Arg Arg Glu Glu Gln 
                645                 650                 655     


Glu Ala Arg Glu Lys Ala Gln Ala Glu Gln Glu Glu Gln Glu Arg Leu 
            660                 665                 670         


Gln Lys Gln Lys Glu Glu Ala Glu Ala Arg Ser Arg Glu Glu Ala Glu 
        675                 680                 685             


Arg Gln Arg Leu Glu Arg Glu Lys His Phe Gln Gln Gln Glu Gln Glu 
    690                 695                 700                 


Arg Gln Glu Arg Arg Lys Arg Leu Glu Glu Ile Met Lys Arg Thr Arg 
705                 710                 715                 720 


Lys Ser Glu Val Ser Glu Thr Lys Gln Lys Gln Asp Ser Lys Glu Ala 
                725                 730                 735     


Asn Ala Asn Gly Ser Ser Pro Glu Pro Val Lys Ala Val Glu Ala Arg 
            740                 745                 750         


Ser Pro Gly Leu Gln Lys Glu Ala Val Gln Lys Glu Glu Pro Ile Pro 
        755                 760                 765             


Gln Glu Pro Gln Trp Ser Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu 
    770                 775                 780                 


Val Asn Gly Leu Gln Pro Leu Pro Ala His Gln Glu Asn Gly Phe Ser 
785                 790                 795                 800 


Thr Asn Gly Pro Ser Gly Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr 
                805                 810                 815     


Leu Leu Pro Phe Ala Glu Ala Glu Ala Phe Leu Lys Lys Ala Val Val 
            820                 825                 830         


Gln Ser Pro Gln Val Thr Glu Val Leu 
        835                 840     


<210> 6344
<211> 164
<212> PRT
<213> Homo sapiens

<400> 6344
Asn Leu Pro Lys His Val Asp Ser Ile Ile Asn Lys Arg Gln Arg Leu 
1               5                   10                  15      


Glu Arg Glu Lys His Phe Gln Gln Gln Glu Gln Glu Arg Gln Glu Arg 
            20                  25                  30          


Arg Lys Arg Leu Glu Glu Ile Met Lys Arg Thr Arg Lys Ser Glu Val 
        35                  40                  45              


Ser Glu Thr Lys Lys Gln Asp Ser Lys Glu Ala Asn Ala Asn Gly Ser 
    50                  55                  60                  


Ser Pro Glu Pro Val Lys Ala Val Glu Ala Arg Ser Pro Gly Leu Gln 
65                  70                  75                  80  


Lys Glu Ala Val Gln Lys Glu Glu Pro Ile Pro Gln Glu Pro Gln Trp 
                85                  90                  95      


Ser Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu Val Asn Gly Leu Gln 
            100                 105                 110         


Pro Leu Pro Ala His Gln Glu Asn Gly Phe Ser Thr Asn Gly Pro Ser 
        115                 120                 125             


Gly Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr Leu Leu Pro Phe Ala 
    130                 135                 140                 


Glu Ala Glu Ala Phe Leu Lys Lys Ala Val Val Gln Ser Pro Gln Val 
145                 150                 155                 160 


Thr Glu Val Leu 
                


<210> 6345
<211> 114
<212> PRT
<213> Homo sapiens

<400> 6345
Met Val Ile Arg Val Tyr Ile Ala Ser Ser Ser Gly Ser Thr Ala Ile 
1               5                   10                  15      


Lys Lys Lys Gln Gln Asp Val Leu Gly Phe Leu Glu Ala Asn Lys Ile 
            20                  25                  30          


Gly Phe Glu Glu Lys Asp Ile Ala Ala Asn Glu Glu Asn Arg Lys Trp 
        35                  40                  45              


Met Arg Glu Asn Val Pro Glu Asn Ser Arg Pro Ala Thr Gly Tyr Pro 
    50                  55                  60                  


Leu Pro Pro Gln Ile Phe Asn Glu Ser Gln Tyr Arg Gly Asp Tyr Asp 
65                  70                  75                  80  


Ala Phe Phe Glu Ala Arg Glu Asn Asn Ala Val Tyr Ala Phe Leu Gly 
                85                  90                  95      


Leu Thr Ala Pro Pro Gly Ser Lys Glu Ala Glu Val Gln Ala Lys Gln 
            100                 105                 110         


Gln Ala 
        


<210> 6346
<211> 178
<212> PRT
<213> Homo sapiens

<400> 6346
Met Ser Gly Phe Ser Thr Glu Glu Arg Ala Ala Pro Phe Ser Leu Glu 
1               5                   10                  15      


Tyr Arg Val Phe Leu Lys Asn Glu Lys Gly Gln Tyr Ile Ser Pro Phe 
            20                  25                  30          


His Asp Ile Pro Ile Tyr Ala Asp Lys Asp Val Phe His Met Val Val 
        35                  40                  45              


Glu Val Pro Arg Trp Ser Asn Ala Lys Met Glu Ile Ala Thr Lys Asp 
    50                  55                  60                  


Pro Leu Asn Pro Ile Lys Gln Asp Val Lys Lys Gly Lys Leu Arg Tyr 
65                  70                  75                  80  


Val Ala Asn Leu Phe Pro Tyr Lys Gly Tyr Ile Trp Asn Tyr Gly Ala 
                85                  90                  95      


Ile Pro Gln Thr Trp Glu Asp Pro Gly His Asn Asp Lys His Thr Gly 
            100                 105                 110         


Cys Cys Gly Asp Asn Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys 
        115                 120                 125             


Val Cys Ala Arg Gly Glu Ile Ile Gly Val Lys Val Leu Gly Ile Leu 
    130                 135                 140                 


Ala Met Ile Asp Glu Gly Glu Thr Asp Trp Lys Val Ile Ala Ile Asn 
145                 150                 155                 160 


Val Asp Asp Pro Asp Ala Ala Asn Tyr Asn Val Cys Asn Ser Val Val 
                165                 170                 175     


Ile Leu 
        


<210> 6347
<211> 289
<212> PRT
<213> Homo sapiens

<400> 6347
Met Ser Gly Phe Ser Thr Glu Glu Arg Ala Ala Pro Phe Ser Leu Glu 
1               5                   10                  15      


Tyr Arg Val Phe Leu Lys Asn Glu Lys Gly Gln Tyr Ile Ser Pro Phe 
            20                  25                  30          


His Asp Ile Pro Ile Tyr Ala Asp Lys Asp Val Phe His Met Val Val 
        35                  40                  45              


Glu Val Pro Arg Trp Ser Asn Ala Lys Met Glu Ile Ala Thr Lys Asp 
    50                  55                  60                  


Pro Leu Asn Pro Ile Lys Gln Asp Val Lys Lys Gly Lys Leu Arg Tyr 
65                  70                  75                  80  


Val Ala Asn Leu Phe Pro Tyr Lys Gly Tyr Ile Trp Asn Tyr Gly Ala 
                85                  90                  95      


Ile Pro Gln Thr Trp Glu Asp Pro Gly His Asn Asp Lys His Thr Gly 
            100                 105                 110         


Cys Cys Gly Asp Asn Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys 
        115                 120                 125             


Val Cys Ala Arg Gly Glu Ile Ile Gly Val Lys Val Leu Gly Ile Leu 
    130                 135                 140                 


Ala Met Ile Asp Glu Gly Glu Thr Asp Trp Lys Val Ile Ala Ile Asn 
145                 150                 155                 160 


Val Asp Asp Pro Asp Ala Ala Asn Tyr Asn Asp Ile Asn Asp Val Lys 
                165                 170                 175     


Arg Leu Lys Pro Gly Tyr Leu Glu Ala Thr Val Asp Trp Phe Arg Arg 
            180                 185                 190         


Tyr Lys Val Pro Asp Gly Lys Pro Glu Asn Glu Phe Ala Phe Asn Ala 
        195                 200                 205             


Glu Phe Lys Asp Lys Asp Phe Ala Ile Asp Ile Ile Lys Ser Thr His 
    210                 215                 220                 


Asp His Trp Lys Ala Leu Val Thr Lys Lys Thr Asn Gly Lys Gly Ile 
225                 230                 235                 240 


Ser Cys Met Asn Thr Thr Leu Ser Glu Ser Pro Phe Lys Cys Asp Pro 
                245                 250                 255     


Asp Ala Ala Arg Ala Ile Val Asp Ala Leu Pro Pro Pro Cys Glu Ser 
            260                 265                 270         


Ala Cys Thr Val Pro Thr Asp Val Asp Lys Trp Phe His His Gln Lys 
        275                 280                 285             


Asn 
    


<210> 6348
<211> 700
<212> PRT
<213> Homo sapiens

<400> 6348
Met Thr Glu Arg Cys Ser Leu Trp Ser Ala Leu Ser Ala Ala Ala Cys 
1               5                   10                  15      


Cys Phe Tyr Arg Gly Ser Phe Val Gln Phe Ser Lys Glu Lys Tyr Ile 
            20                  25                  30          


Leu Asp Ser Ser Pro Glu Lys Leu His Lys Glu Leu Glu Glu Glu Leu 
        35                  40                  45              


Lys Leu Ser Ser Thr Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg 
    50                  55                  60                  


Ile Pro Arg Glu Val Ser Glu Thr Leu Val Gln Arg Asn Gly Asp Phe 
65                  70                  75                  80  


Leu Ile Arg Asp Ser Leu Thr Ser Leu Gly Asp Tyr Val Leu Thr Cys 
                85                  90                  95      


Arg Trp Arg Asn Gln Ala Leu His Phe Lys Ile Asn Lys Val Val Val 
            100                 105                 110         


Lys Ala Gly Glu Ser Tyr Thr His Ile Gln Tyr Leu Phe Glu Gln Glu 
        115                 120                 125             


Ser Phe Asp His Val Pro Ala Leu Val Arg Tyr His Val Gly Ser Arg 
    130                 135                 140                 


Lys Ala Val Ser Glu Gln Ser Gly Ala Ile Ile Tyr Cys Pro Val Asn 
145                 150                 155                 160 


Arg Thr Phe Pro Leu Arg Tyr Leu Glu Ala Ser Tyr Gly Leu Gly Gln 
                165                 170                 175     


Gly Ser Ser Lys Pro Ala Ser Pro Val Ser Pro Ser Gly Pro Lys Gly 
            180                 185                 190         


Ser His Met Lys Arg Arg Ser Val Thr Met Thr Asp Gly Leu Thr Ala 
        195                 200                 205             


Asp Lys Val Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr Ser Leu Pro 
    210                 215                 220                 


Arg Pro Arg Asp Ser Ile Arg Ser Cys Ala Leu Ser Met Asp Gln Ile 
225                 230                 235                 240 


Pro Asp Leu His Ser Pro Met Ser Pro Ile Ser Glu Ser Pro Ser Ser 
                245                 250                 255     


Pro Ala Tyr Ser Thr Val Thr Arg Val His Ala Ala Pro Ala Ala Pro 
            260                 265                 270         


Ser Ala Thr Ala Leu Pro Ala Ser Pro Val Ala Arg Arg Ser Ser Glu 
        275                 280                 285             


Pro Gln Leu Cys Pro Gly Ser Ala Pro Lys Thr His Gly Glu Ser Asp 
    290                 295                 300                 


Lys Gly Pro His Thr Ser Pro Ser His Thr Leu Gly Lys Ala Ser Pro 
305                 310                 315                 320 


Ser Pro Ser Leu Ser Ser Tyr Ser Asp Pro Asp Ser Gly His Tyr Cys 
                325                 330                 335     


Gln Leu Gln Pro Pro Val Arg Gly Ser Arg Glu Trp Ala Ala Thr Glu 
            340                 345                 350         


Thr Ser Ser Gln Gln Ala Arg Ser Tyr Gly Glu Arg Leu Lys Glu Leu 
        355                 360                 365             


Ser Glu Asn Gly Ala Pro Glu Gly Asp Trp Gly Lys Thr Phe Thr Val 
    370                 375                 380                 


Pro Ile Val Glu Val Thr Ser Ser Phe Asn Pro Ala Thr Phe Gln Ser 
385                 390                 395                 400 


Leu Leu Ile Pro Arg Asp Asn Arg Pro Leu Glu Val Gly Leu Leu Arg 
                405                 410                 415     


Lys Val Lys Glu Leu Leu Ala Glu Val Asp Ala Arg Thr Leu Ala Arg 
            420                 425                 430         


His Val Thr Lys Val Asp Cys Leu Val Ala Arg Ile Leu Gly Val Thr 
        435                 440                 445             


Lys Glu Met Gln Thr Leu Met Gly Val Arg Trp Gly Met Glu Leu Leu 
    450                 455                 460                 


Thr Leu Pro His Gly Arg Gln Leu Arg Leu Asp Leu Leu Glu Arg Phe 
465                 470                 475                 480 


His Thr Met Ser Ile Met Leu Ala Val Asp Ile Leu Gly Cys Thr Gly 
                485                 490                 495     


Ser Ala Glu Glu Arg Ala Ala Leu Leu His Lys Thr Ile Gln Leu Ala 
            500                 505                 510         


Ala Glu Leu Arg Gly Thr Met Gly Asn Met Phe Ser Phe Ala Ala Val 
        515                 520                 525             


Met Gly Ala Leu Asp Met Ala Gln Ile Ser Arg Leu Glu Gln Thr Trp 
    530                 535                 540                 


Val Thr Leu Arg Gln Arg His Thr Glu Gly Ala Ile Leu Tyr Glu Lys 
545                 550                 555                 560 


Lys Leu Lys Pro Phe Leu Lys Ser Leu Asn Glu Gly Lys Glu Gly Pro 
                565                 570                 575     


Pro Leu Ser Asn Thr Thr Phe Pro His Val Leu Pro Leu Ile Thr Leu 
            580                 585                 590         


Leu Glu Cys Asp Ser Ala Pro Pro Glu Gly Pro Glu Pro Trp Gly Ser 
        595                 600                 605             


Thr Glu His Gly Val Glu Val Val Leu Ala His Leu Glu Ala Ala Arg 
    610                 615                 620                 


Thr Val Ala His His Gly Gly Leu Tyr His Thr Asn Ala Glu Val Lys 
625                 630                 635                 640 


Leu Gln Gly Phe Gln Ala Arg Pro Glu Leu Leu Glu Val Phe Ser Thr 
                645                 650                 655     


Glu Phe Gln Met Arg Leu Leu Trp Gly Ser Gln Gly Ala Ser Ser Ser 
            660                 665                 670         


Gln Ala Arg Arg Tyr Glu Lys Phe Asp Lys Val Leu Thr Ala Leu Ser 
        675                 680                 685             


His Lys Leu Glu Pro Ala Val Arg Ser Ser Glu Leu 
    690                 695                 700 


<210> 6349
<211> 792
<212> PRT
<213> Homo sapiens

<400> 6349
Met Ala Pro Ala Leu Pro Ser Pro His Lys Ala Val Ala Arg Pro Glu 
1               5                   10                  15      


Leu Leu Leu Asp Thr Ala Ala His Ser Gly Lys Leu Arg Ala Pro Asp 
            20                  25                  30          


Gly Gly Glu Gly Ala Glu Cys Ala Gly His Asn Gly Gly Pro Ser Trp 
        35                  40                  45              


Gly Val Gly Gln Gly Gln Ser Gln Glu Pro Ser Arg Gln Gly Ile Pro 
    50                  55                  60                  


Gln Ala Pro Trp Leu Val Ser Trp Gln Arg Arg Gly Phe Pro Pro Ser 
65                  70                  75                  80  


Ser Phe Cys Pro Gly Pro Leu Arg Thr Glu Lys Leu Arg Ala Gly Arg 
                85                  90                  95      


Cys Pro Leu Leu Leu Cys Gly Gly Ala Ala Gly Glu Pro Glu Ala Gly 
            100                 105                 110         


Ser Asp Tyr Val Lys Phe Ser Lys Glu Lys Tyr Ile Leu Asp Ser Ser 
        115                 120                 125             


Pro Glu Lys Leu His Lys Glu Leu Glu Glu Glu Leu Lys Leu Ser Ser 
    130                 135                 140                 


Thr Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro Arg Glu 
145                 150                 155                 160 


Val Ser Glu Thr Leu Val Gln Arg Asn Gly Asp Phe Leu Ile Arg Asp 
                165                 170                 175     


Ser Leu Thr Ser Leu Gly Asp Tyr Val Leu Thr Cys Arg Trp Arg Asn 
            180                 185                 190         


Gln Ala Leu His Phe Lys Ile Asn Lys Val Val Val Lys Ala Gly Glu 
        195                 200                 205             


Ser Tyr Thr His Ile Gln Tyr Leu Phe Glu Gln Glu Ser Phe Asp His 
    210                 215                 220                 


Val Pro Ala Leu Val Arg Tyr His Val Gly Ser Arg Lys Ala Val Ser 
225                 230                 235                 240 


Glu Gln Ser Gly Ala Ile Ile Tyr Cys Pro Val Asn Arg Thr Phe Pro 
                245                 250                 255     


Leu Arg Tyr Leu Glu Ala Ser Tyr Gly Leu Gly Gln Gly Ser Ser Lys 
            260                 265                 270         


Pro Ala Ser Pro Val Ser Pro Ser Gly Pro Lys Gly Ser His Met Lys 
        275                 280                 285             


Arg Arg Ser Val Thr Met Thr Asp Gly Leu Thr Ala Asp Lys Val Thr 
    290                 295                 300                 


Arg Ser Asp Gly Cys Pro Thr Ser Thr Ser Leu Pro Arg Pro Arg Asp 
305                 310                 315                 320 


Ser Ile Arg Ser Cys Ala Leu Ser Met Asp Gln Ile Pro Asp Leu His 
                325                 330                 335     


Ser Pro Met Ser Pro Ile Ser Glu Ser Pro Ser Ser Pro Ala Tyr Ser 
            340                 345                 350         


Thr Val Thr Arg Val His Ala Ala Pro Ala Ala Pro Ser Ala Thr Ala 
        355                 360                 365             


Leu Pro Ala Ser Pro Val Ala Arg Arg Ser Ser Glu Pro Gln Leu Cys 
    370                 375                 380                 


Pro Gly Ser Ala Pro Lys Thr His Gly Glu Ser Asp Lys Gly Pro His 
385                 390                 395                 400 


Thr Ser Pro Ser His Thr Leu Gly Lys Ala Ser Pro Ser Pro Ser Leu 
                405                 410                 415     


Ser Ser Tyr Ser Asp Pro Asp Ser Gly His Tyr Cys Gln Leu Gln Pro 
            420                 425                 430         


Pro Val Arg Gly Ser Arg Glu Trp Ala Ala Thr Glu Thr Ser Ser Gln 
        435                 440                 445             


Gln Ala Arg Ser Tyr Gly Glu Arg Leu Lys Glu Leu Ser Glu Asn Gly 
    450                 455                 460                 


Ala Pro Glu Gly Asp Trp Gly Lys Thr Phe Thr Val Pro Ile Val Glu 
465                 470                 475                 480 


Val Thr Ser Ser Phe Asn Pro Ala Thr Phe Gln Ser Leu Leu Ile Pro 
                485                 490                 495     


Arg Asp Asn Arg Pro Leu Glu Val Gly Leu Leu Arg Lys Val Lys Glu 
            500                 505                 510         


Leu Leu Ala Glu Val Asp Ala Arg Thr Leu Ala Arg His Val Thr Lys 
        515                 520                 525             


Val Asp Cys Leu Val Ala Arg Ile Leu Gly Val Thr Lys Glu Met Gln 
    530                 535                 540                 


Thr Leu Met Gly Val Arg Trp Gly Met Glu Leu Leu Thr Leu Pro His 
545                 550                 555                 560 


Gly Arg Gln Leu Arg Leu Asp Leu Leu Glu Arg Phe His Thr Met Ser 
                565                 570                 575     


Ile Met Leu Ala Val Asp Ile Leu Gly Cys Thr Gly Ser Ala Glu Glu 
            580                 585                 590         


Arg Ala Ala Leu Leu His Lys Thr Ile Gln Leu Ala Ala Glu Leu Arg 
        595                 600                 605             


Gly Thr Met Gly Asn Met Phe Ser Phe Ala Ala Val Met Gly Ala Leu 
    610                 615                 620                 


Asp Met Ala Gln Ile Ser Arg Leu Glu Gln Thr Trp Val Thr Leu Arg 
625                 630                 635                 640 


Gln Arg His Thr Glu Gly Ala Ile Leu Tyr Glu Lys Lys Leu Lys Pro 
                645                 650                 655     


Phe Leu Lys Ser Leu Asn Glu Gly Lys Glu Gly Pro Pro Leu Ser Asn 
            660                 665                 670         


Thr Thr Phe Pro His Val Leu Pro Leu Ile Thr Leu Leu Glu Cys Asp 
        675                 680                 685             


Ser Ala Pro Pro Glu Gly Pro Glu Pro Trp Gly Ser Thr Glu His Gly 
    690                 695                 700                 


Val Glu Val Val Leu Ala His Leu Glu Ala Ala Arg Thr Val Ala His 
705                 710                 715                 720 


His Gly Gly Leu Tyr His Thr Asn Ala Glu Val Lys Leu Gln Gly Phe 
                725                 730                 735     


Gln Ala Arg Pro Glu Leu Leu Glu Val Phe Ser Thr Glu Phe Gln Met 
            740                 745                 750         


Arg Leu Leu Trp Gly Ser Gln Gly Ala Ser Ser Ser Gln Ala Arg Arg 
        755                 760                 765             


Tyr Glu Lys Phe Asp Lys Val Leu Thr Ala Leu Ser His Lys Leu Glu 
    770                 775                 780                 


Pro Ala Val Arg Ser Ser Glu Leu 
785                 790         


<210> 6350
<211> 703
<212> PRT
<213> Homo sapiens

<400> 6350
Met Thr Ala Val Gly Arg Arg Cys Pro Ala Leu Gly Ser Arg Gly Ala 
1               5                   10                  15      


Ala Gly Glu Pro Glu Ala Gly Ser Asp Tyr Val Lys Phe Ser Lys Glu 
            20                  25                  30          


Lys Tyr Ile Leu Asp Ser Ser Pro Glu Lys Leu His Lys Glu Leu Glu 
        35                  40                  45              


Glu Glu Leu Lys Leu Ser Ser Thr Asp Leu Arg Ser His Ala Trp Tyr 
    50                  55                  60                  


His Gly Arg Ile Pro Arg Glu Val Ser Glu Thr Leu Val Gln Arg Asn 
65                  70                  75                  80  


Gly Asp Phe Leu Ile Arg Asp Ser Leu Thr Ser Leu Gly Asp Tyr Val 
                85                  90                  95      


Leu Thr Cys Arg Trp Arg Asn Gln Ala Leu His Phe Lys Ile Asn Lys 
            100                 105                 110         


Val Val Val Lys Ala Gly Glu Ser Tyr Thr His Ile Gln Tyr Leu Phe 
        115                 120                 125             


Glu Gln Glu Ser Phe Asp His Val Pro Ala Leu Val Arg Tyr His Val 
    130                 135                 140                 


Gly Ser Arg Lys Ala Val Ser Glu Gln Ser Gly Ala Ile Ile Tyr Cys 
145                 150                 155                 160 


Pro Val Asn Arg Thr Phe Pro Leu Arg Tyr Leu Glu Ala Ser Tyr Gly 
                165                 170                 175     


Leu Gly Gln Gly Ser Ser Lys Pro Ala Ser Pro Val Ser Pro Ser Gly 
            180                 185                 190         


Pro Lys Gly Ser His Met Lys Arg Arg Ser Val Thr Met Thr Asp Gly 
        195                 200                 205             


Leu Thr Ala Asp Lys Val Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr 
    210                 215                 220                 


Ser Leu Pro Arg Pro Arg Asp Ser Ile Arg Ser Cys Ala Leu Ser Met 
225                 230                 235                 240 


Asp Gln Ile Pro Asp Leu His Ser Pro Met Ser Pro Ile Ser Glu Ser 
                245                 250                 255     


Pro Ser Ser Pro Ala Tyr Ser Thr Val Thr Arg Val His Ala Ala Pro 
            260                 265                 270         


Ala Ala Pro Ser Ala Thr Ala Leu Pro Ala Ser Pro Val Ala Arg Arg 
        275                 280                 285             


Ser Ser Glu Pro Gln Leu Cys Pro Gly Ser Ala Pro Lys Thr His Gly 
    290                 295                 300                 


Glu Ser Asp Lys Gly Pro His Thr Ser Pro Ser His Thr Leu Gly Lys 
305                 310                 315                 320 


Ala Ser Pro Ser Pro Ser Leu Ser Ser Tyr Ser Asp Pro Asp Ser Gly 
                325                 330                 335     


His Tyr Cys Gln Leu Gln Pro Pro Val Arg Gly Ser Arg Glu Trp Ala 
            340                 345                 350         


Ala Thr Glu Thr Ser Ser Gln Gln Ala Arg Ser Tyr Gly Glu Arg Leu 
        355                 360                 365             


Lys Glu Leu Ser Glu Asn Gly Ala Pro Glu Gly Asp Trp Gly Lys Thr 
    370                 375                 380                 


Phe Thr Val Pro Ile Val Glu Val Thr Ser Ser Phe Asn Pro Ala Thr 
385                 390                 395                 400 


Phe Gln Ser Leu Leu Ile Pro Arg Asp Asn Arg Pro Leu Glu Val Gly 
                405                 410                 415     


Leu Leu Arg Lys Val Lys Glu Leu Leu Ala Glu Val Asp Ala Arg Thr 
            420                 425                 430         


Leu Ala Arg His Val Thr Lys Val Asp Cys Leu Val Ala Arg Ile Leu 
        435                 440                 445             


Gly Val Thr Lys Glu Met Gln Thr Leu Met Gly Val Arg Trp Gly Met 
    450                 455                 460                 


Glu Leu Leu Thr Leu Pro His Gly Arg Gln Leu Arg Leu Asp Leu Leu 
465                 470                 475                 480 


Glu Arg Phe His Thr Met Ser Ile Met Leu Ala Val Asp Ile Leu Gly 
                485                 490                 495     


Cys Thr Gly Ser Ala Glu Glu Arg Ala Ala Leu Leu His Lys Thr Ile 
            500                 505                 510         


Gln Leu Ala Ala Glu Leu Arg Gly Thr Met Gly Asn Met Phe Ser Phe 
        515                 520                 525             


Ala Ala Val Met Gly Ala Leu Asp Met Ala Gln Ile Ser Arg Leu Glu 
    530                 535                 540                 


Gln Thr Trp Val Thr Leu Arg Gln Arg His Thr Glu Gly Ala Ile Leu 
545                 550                 555                 560 


Tyr Glu Lys Lys Leu Lys Pro Phe Leu Lys Ser Leu Asn Glu Gly Lys 
                565                 570                 575     


Glu Gly Pro Pro Leu Ser Asn Thr Thr Phe Pro His Val Leu Pro Leu 
            580                 585                 590         


Ile Thr Leu Leu Glu Cys Asp Ser Ala Pro Pro Glu Gly Pro Glu Pro 
        595                 600                 605             


Trp Gly Ser Thr Glu His Gly Val Glu Val Val Leu Ala His Leu Glu 
    610                 615                 620                 


Ala Ala Arg Thr Val Ala His His Gly Gly Leu Tyr His Thr Asn Ala 
625                 630                 635                 640 


Glu Val Lys Leu Gln Gly Phe Gln Ala Arg Pro Glu Leu Leu Glu Val 
                645                 650                 655     


Phe Ser Thr Glu Phe Gln Met Arg Leu Leu Trp Gly Ser Gln Gly Ala 
            660                 665                 670         


Ser Ser Ser Gln Ala Arg Arg Tyr Glu Lys Phe Asp Lys Val Leu Thr 
        675                 680                 685             


Ala Leu Ser His Lys Leu Glu Pro Ala Val Arg Ser Ser Glu Leu 
    690                 695                 700             


<210> 6351
<211> 622
<212> PRT
<213> Homo sapiens

<400> 6351
Met Asp Gln Leu Pro Gln Lys Asn Leu Leu Arg Leu His Pro Ala Gly 
1               5                   10                  15      


Ser Ala Gly Cys Ser Thr Gly Val Glu Ser Ser Ser Met Asp Gly Phe 
            20                  25                  30          


Trp Met Glu Val Glu Gln Ile Gln Gln Arg Asp Glu Leu Arg Glu Glu 
        35                  40                  45              


Asp Ser Gly Gly Asn Glu Gly Gln Leu Pro Glu Glu Gly Glu Ala Glu 
    50                  55                  60                  


Ser Gln Trp Leu Gln Asp Thr Gly Leu Ser Gly Leu Leu Gly Gly Leu 
65                  70                  75                  80  


Gly Leu Asp Gly Asp His Gln Glu Leu Leu Ser Thr Leu Thr Gln Thr 
                85                  90                  95      


Gln Val Ala Ala Val Cys Arg Arg Leu Asp Ile Tyr Ala Arg Ser Val 
            100                 105                 110         


Arg Arg Gln His Lys Thr Pro Val Arg Asp Val Arg Asp Val Phe Gly 
        115                 120                 125             


Val Phe Asn Ser Gly Lys Met Ser Ser Glu Asn Gly Asp Ser Gly Met 
    130                 135                 140                 


Lys Gly Ala Gln Leu Ser Ser Gly Ala Ser Lys Phe Pro Pro Ala Ala 
145                 150                 155                 160 


Glu Pro Gly Gly Leu Gln Glu Gln Ala Gly Arg Glu Glu Ala Phe Asn 
                165                 170                 175     


Met Asp Ser Ala Tyr Ser Glu Gln Ala Ala Val Leu Leu Gln Arg Ser 
            180                 185                 190         


Arg Pro Ser Arg Gly Gly Thr Ser Ala Trp Gly Lys Cys Ser Leu Pro 
        195                 200                 205             


Lys Phe Thr Val Pro Lys Gly Arg Leu Gly Val Thr Arg Ile Gly Asp 
    210                 215                 220                 


Leu Ser Leu Gln Asp Met Arg Lys Val Pro Ser Leu Ala Leu Ile Glu 
225                 230                 235                 240 


Leu Thr Ala Leu Cys Asp Ile Leu Gly Leu Asp Leu Lys Arg Ser Lys 
                245                 250                 255     


Ala Gly Lys Trp Lys Ala Ala Glu Thr Arg Leu Phe Gly Val Pro Leu 
            260                 265                 270         


Asp Ser Leu Leu Glu Ala Asp His Lys Val Leu Pro Ser Thr Gln Val 
        275                 280                 285             


Pro Leu Val Leu Gln Ala Leu Leu Ser Cys Leu Glu Lys Arg Gly Leu 
    290                 295                 300                 


Asp Met Glu Gly Ile Leu Arg Val Pro Gly Ser Gln Ala Arg Val Lys 
305                 310                 315                 320 


Gly Leu Glu Gln Lys Leu Glu Arg Asp Phe Tyr Ala Gly Leu Phe Ser 
                325                 330                 335     


Trp Asp Glu Val His His Asn Asp Ala Ser Asp Leu Leu Lys Arg Phe 
            340                 345                 350         


Ile Arg Lys Leu Pro Thr Pro Leu Leu Thr Ala Glu Tyr Leu Pro Ala 
        355                 360                 365             


Phe Ala Val Val Pro Asn Ile Pro Asn Leu Lys Gln Arg Leu Gln Val 
    370                 375                 380                 


Leu His Leu Leu Ile Leu Ile Leu Pro Glu Pro Asn Arg Asn Ala Leu 
385                 390                 395                 400 


Lys Ala Leu Leu Glu Phe Leu Arg Lys Val Val Ala Arg Glu Gln His 
                405                 410                 415     


Asn Lys Met Thr Leu Arg Asn Val Ser Thr Val Met Ala Pro Asn Leu 
            420                 425                 430         


Phe Leu His Gln Gly Arg Pro Pro Lys Leu Pro Lys Gly Lys Glu Lys 
        435                 440                 445             


Gln Leu Ala Glu Gly Ala Ala Glu Val Val Gln Ile Met Val His Tyr 
    450                 455                 460                 


Gln Asp Leu Leu Trp Thr Val Ala Ser Phe Leu Val Ala Gln Val Arg 
465                 470                 475                 480 


Lys Leu Asn Asp Ser Ser Ser Arg Arg Pro Gln Leu Cys Asp Ala Gly 
                485                 490                 495     


Leu Lys Thr Trp Leu Arg Arg Met His Ala Asp Arg Asp Lys Ala Gly 
            500                 505                 510         


Asp Gly Leu Glu Ala Thr Pro Lys Val Ala Lys Ile Gln Val Val Trp 
        515                 520                 525             


Pro Ile Lys Asp Pro Leu Lys Val Pro Leu Thr Pro Ser Thr Lys Val 
    530                 535                 540                 


Ala His Val Leu Arg Gln Phe Thr Glu His Leu Ser Pro Gly Ser Lys 
545                 550                 555                 560 


Gly Gln Glu Asp Ser Glu Asp Met Asp Ser Leu Leu Leu His His Arg 
                565                 570                 575     


Ser Met Glu Ser Ala Asn Ile Leu Leu Tyr Glu Val Gly Gly Asn Ile 
            580                 585                 590         


Asn Glu His Arg Leu Asp Pro Asp Ala Tyr Leu Leu Asp Leu Tyr Arg 
        595                 600                 605             


Ala Asn Pro His Gly Glu Trp Val Leu Lys Gln Asn Pro Thr 
    610                 615                 620         


<210> 6352
<211> 281
<212> PRT
<213> Homo sapiens

<400> 6352
Met Ala Thr Glu Leu Gln Cys Pro Asp Ser Met Pro Cys His Asn Gln 
1               5                   10                  15      


Gln Val Asn Ser Ala Ser Thr Pro Ser Pro Glu Gln Leu Arg Pro Gly 
            20                  25                  30          


Asp Leu Ile Leu Asp His Ala Gly Gly Asn Arg Ala Ser Arg Ala Lys 
        35                  40                  45              


Val Ile Leu Leu Thr Gly Tyr Ala His Ser Ser Leu Pro Ala Glu Leu 
    50                  55                  60                  


Asp Ser Gly Ala Cys Gly Gly Ser Ser Leu Asn Ser Glu Gly Asn Ser 
65                  70                  75                  80  


Gly Ser Gly Asp Ser Ser Ser Tyr Asp Ala Pro Ala Gly Asn Ser Phe 
                85                  90                  95      


Leu Glu Asp Cys Glu Leu Ser Arg Gln Ile Gly Ala Gln Leu Lys Leu 
            100                 105                 110         


Leu Pro Met Asn Asp Gln Ile Arg Glu Leu Gln Thr Ile Ile Arg Asp 
        115                 120                 125             


Lys Thr Ala Ser Arg Gly Asp Phe Met Phe Ser Ala Asp Arg Leu Ile 
    130                 135                 140                 


Arg Leu Val Val Glu Glu Gly Leu Asn Gln Leu Pro Tyr Lys Glu Cys 
145                 150                 155                 160 


Met Val Thr Thr Pro Thr Gly Tyr Lys Tyr Glu Gly Val Lys Phe Glu 
                165                 170                 175     


Lys Gly Asn Cys Gly Val Ser Ile Met Arg Ser Gly Glu Ala Met Glu 
            180                 185                 190         


Gln Gly Leu Arg Asp Cys Cys Arg Ser Ile Arg Ile Gly Lys Ile Leu 
        195                 200                 205             


Ile Gln Ser Asp Glu Glu Thr Gln Arg Ala Lys Val Tyr Tyr Ala Lys 
    210                 215                 220                 


Phe Pro Pro Asp Ile Tyr Arg Arg Lys Val Leu Leu Met Tyr Pro Ile 
225                 230                 235                 240 


Leu Ser Thr Gly Asn Thr Val Ile Glu Ala Val Lys Val Leu Ile Glu 
                245                 250                 255     


His Gly Val Gln Pro Ser Val Ile Ile Leu Leu Ser Leu Phe Ser Thr 
            260                 265                 270         


Pro His Gly Glu Phe Ser Met Arg Gln 
        275                 280     


<210> 6353
<211> 309
<212> PRT
<213> Homo sapiens

<400> 6353
Met Ala Thr Glu Leu Gln Cys Pro Asp Ser Met Pro Cys His Asn Gln 
1               5                   10                  15      


Gln Val Asn Ser Ala Ser Thr Pro Ser Pro Glu Gln Leu Arg Pro Gly 
            20                  25                  30          


Asp Leu Ile Leu Asp His Ala Gly Gly Asn Arg Ala Ser Arg Ala Lys 
        35                  40                  45              


Val Ile Leu Leu Thr Gly Tyr Ala His Ser Ser Leu Pro Ala Glu Leu 
    50                  55                  60                  


Asp Ser Gly Ala Cys Gly Gly Ser Ser Leu Asn Ser Glu Gly Asn Ser 
65                  70                  75                  80  


Gly Ser Gly Asp Ser Ser Ser Tyr Asp Ala Pro Ala Gly Asn Ser Phe 
                85                  90                  95      


Leu Glu Asp Cys Glu Leu Ser Arg Gln Ile Gly Ala Gln Leu Lys Leu 
            100                 105                 110         


Leu Pro Met Asn Asp Gln Ile Arg Glu Leu Gln Thr Ile Ile Arg Asp 
        115                 120                 125             


Lys Thr Ala Ser Arg Gly Asp Phe Met Phe Ser Ala Asp Arg Leu Ile 
    130                 135                 140                 


Arg Leu Val Val Glu Glu Gly Leu Asn Gln Leu Pro Tyr Lys Glu Cys 
145                 150                 155                 160 


Met Val Thr Thr Pro Thr Gly Tyr Lys Tyr Glu Gly Val Lys Phe Glu 
                165                 170                 175     


Lys Gly Asn Cys Gly Val Ser Ile Met Arg Ser Gly Glu Ala Met Glu 
            180                 185                 190         


Gln Gly Leu Arg Asp Cys Cys Arg Ser Ile Arg Ile Gly Lys Ile Leu 
        195                 200                 205             


Ile Gln Ser Asp Glu Glu Thr Gln Arg Ala Lys Val Tyr Tyr Ala Lys 
    210                 215                 220                 


Phe Pro Pro Asp Ile Tyr Arg Arg Lys Val Leu Leu Met Tyr Pro Ile 
225                 230                 235                 240 


Leu Ser Thr Gly Asn Thr Val Ile Glu Ala Val Lys Val Leu Ile Glu 
                245                 250                 255     


His Gly Val Gln Pro Ser Val Ile Ile Leu Leu Ser Leu Phe Ser Thr 
            260                 265                 270         


Pro His Gly Ala Lys Ser Ile Ile Gln Glu Phe Pro Glu Ile Thr Ile 
        275                 280                 285             


Leu Thr Thr Glu Val His Pro Val Ala Pro Thr His Phe Gly Gln Lys 
    290                 295                 300                 


Tyr Phe Gly Thr Asp 
305                 


<210> 6354
<211> 210
<212> PRT
<213> Homo sapiens

<400> 6354
Met Val Ser Gly Ser Glu Gln Lys Phe Leu Ile Gly Leu Gly Lys Ser 
1               5                   10                  15      


Gln Ile Tyr Thr Trp Asp Gly Arg Gln Ser Asp Arg Trp Ile Lys Leu 
            20                  25                  30          


Asp Leu Lys Thr Glu Leu Pro Arg Asp Thr Leu Leu Ser Val Glu Ile 
        35                  40                  45              


Val His Glu Leu Lys Gly Glu Gly Lys Ala Gln Arg Lys Ile Ser Ala 
    50                  55                  60                  


Ile His Ile Leu Asp Val Leu Val Leu Asn Gly Thr Asp Val Arg Glu 
65                  70                  75                  80  


Gln His Phe Asn Gln Arg Ile Gln Leu Ala Glu Lys Phe Val Lys Ala 
                85                  90                  95      


Val Ser Lys Pro Ser Arg Pro Asp Met Asn Pro Ile Arg Val Lys Glu 
            100                 105                 110         


Val Tyr Arg Leu Glu Glu Met Glu Lys Ile Phe Val Arg Leu Glu Met 
        115                 120                 125             


Lys Ile Ile Lys Gly Ser Ser Gly Thr Pro Lys Leu Ser Tyr Thr Gly 
    130                 135                 140                 


Arg Asp Asp Arg His Phe Val Pro Met Gly Leu Tyr Ile Val Arg Thr 
145                 150                 155                 160 


Val Asn Glu Pro Trp Thr Met Gly Phe Ser Lys Ser Phe Lys Lys Lys 
                165                 170                 175     


Phe Phe Tyr Asn Lys Lys Thr Lys Asp Ser Thr Phe Asp Leu Pro Ala 
            180                 185                 190         


Asp Ser Ile Ala Pro Phe His Leu Pro Ser Leu Ala Cys Leu Ser Lys 
        195                 200                 205             


Met Asp 
    210 


<210> 6355
<211> 372
<212> PRT
<213> Homo sapiens

<400> 6355
Met Lys Arg Arg Thr Asp Pro Glu Cys Thr Ala Pro Ile Lys Lys Gln 
1               5                   10                  15      


Lys Lys Arg Val Ala Glu Leu Ala Leu Ser Leu Ser Ser Thr Ser Asp 
            20                  25                  30          


Asp Glu Pro Pro Ser Ser Val Ser His Gly Ala Lys Ala Ser Thr Thr 
        35                  40                  45              


Ser Leu Ser Gly Ser Asp Ser Glu Thr Glu Gly Lys Gln His Ser Ser 
    50                  55                  60                  


Asp Ser Phe Asp Asp Ala Phe Lys Ala Asp Ser Leu Val Glu Gly Thr 
65                  70                  75                  80  


Ser Ser Arg Tyr Ser Met Tyr Asn Ser Val Ser Gln Lys Leu Met Ala 
                85                  90                  95      


Lys Met Gly Phe Arg Glu Gly Glu Gly Leu Gly Lys Tyr Ser Gln Gly 
            100                 105                 110         


Arg Lys Asp Ile Val Glu Ala Ser Ser Gln Lys Gly Arg Arg Gly Leu 
        115                 120                 125             


Gly Leu Thr Leu Arg Gly Phe Asp Gln Glu Leu Asn Val Asp Trp Arg 
    130                 135                 140                 


Asp Glu Pro Glu Pro Ser Ala Cys Glu Gln Val Ser Trp Phe Pro Glu 
145                 150                 155                 160 


Cys Thr Thr Glu Ile Pro Asp Thr Gln Glu Met Ser Asp Trp Met Val 
                165                 170                 175     


Val Gly Lys Arg Lys Met Ile Ile Glu Asp Glu Thr Glu Phe Cys Gly 
            180                 185                 190         


Glu Glu Leu Leu His Ser Val Leu Gln Cys Lys Lys Pro Leu Val Lys 
        195                 200                 205             


Asp Arg Glu Ala Glu Leu Leu Tyr Phe Ala Asp Val Cys Ala Gly Pro 
    210                 215                 220                 


Gly Gly Phe Ser Glu Tyr Val Leu Trp Arg Lys Lys Trp His Ala Lys 
225                 230                 235                 240 


Gly Phe Gly Met Thr Leu Lys Gly Pro Asn Asp Phe Lys Leu Glu Asp 
                245                 250                 255     


Phe Tyr Ser Ala Ser Ser Glu Leu Phe Glu Pro Tyr Tyr Gly Glu Gly 
            260                 265                 270         


Gly Ile Asp Gly Asp Gly Asp Ile Thr Arg Pro Glu Asn Ile Ser Ala 
        275                 280                 285             


Phe Arg Asn Phe Val Leu Asp Asn Thr Asp Arg Lys Gly Val His Phe 
    290                 295                 300                 


Leu Met Ala Asp Gly Gly Phe Ser Val Glu Gly Gln Glu Asn Leu Gln 
305                 310                 315                 320 


Glu Ile Leu Ser Lys Gln Leu Leu Leu Cys Gln Phe Leu Met Ala Leu 
                325                 330                 335     


Ser Ile Val Arg Thr Gly Gly His Phe Ile Cys Lys Thr Phe Asp Leu 
            340                 345                 350         


Phe Thr Pro Phe Ser Val Gly Leu Val Tyr Leu Leu Tyr Cys Cys Phe 
        355                 360                 365             


Glu Arg Val Cys 
    370         


<210> 6356
<211> 204
<212> PRT
<213> Homo sapiens

<400> 6356
Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ile Ala Ser 
                85                  90                  95      


Val Ile Asn Ser Ala Leu Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val 
            100                 105                 110         


Asp Ile Phe Ala Glu Leu Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr 
        115                 120                 125             


Val Ala Val Ser Ile Ile Ala Lys Lys Glu Val Leu Leu Asp Gln Pro 
    130                 135                 140                 


Gly Arg Glu Glu Glu Asn Gly Ser Thr Ser Lys Thr Ile Val Tyr His 
145                 150                 155                 160 


Leu Asp Glu Gly Val Tyr Gly Ile Phe Asn Ser Val Leu Phe Asp Asn 
                165                 170                 175     


Ile Cys Pro Thr Pro Ile Leu Gln Lys Ser Lys Asn His Ser Pro Cys 
            180                 185                 190         


Tyr Met Ser Leu Glu Ser Ile His Phe Ile Ala Val 
        195                 200                 


<210> 6357
<211> 480
<212> PRT
<213> Homo sapiens

<400> 6357
Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ala Glu Met 
                85                  90                  95      


Glu Leu Val Gln His Ile Gly Ile Pro Ala Ser Lys Ile Ile Cys Ala 
            100                 105                 110         


Asn Pro Cys Lys Gln Ile Ala Gln Ile Lys Tyr Ala Ala Lys His Gly 
        115                 120                 125             


Ile Gln Leu Leu Ser Phe Asp Asn Glu Met Glu Leu Ala Lys Val Val 
    130                 135                 140                 


Lys Ser His Pro Ser Ala Lys Met Val Leu Cys Ile Ala Thr Asp Asp 
145                 150                 155                 160 


Ser His Ser Leu Ser Cys Leu Ser Leu Lys Phe Gly Val Ser Leu Lys 
                165                 170                 175     


Ser Cys Arg His Leu Leu Glu Asn Ala Lys Lys His His Val Glu Val 
            180                 185                 190         


Val Gly Val Ser Phe His Ile Gly Ser Gly Cys Pro Asp Pro Gln Ala 
        195                 200                 205             


Tyr Ala Gln Ser Ile Ala Asp Ala Arg Leu Val Phe Glu Met Gly Thr 
    210                 215                 220                 


Glu Leu Gly His Lys Met His Val Leu Asp Leu Gly Gly Gly Phe Pro 
225                 230                 235                 240 


Gly Thr Glu Gly Ala Lys Val Arg Phe Glu Glu Ile Ala Ser Val Ile 
                245                 250                 255     


Asn Ser Ala Leu Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val Asp Ile 
            260                 265                 270         


Phe Ala Glu Leu Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr Val Ala 
        275                 280                 285             


Val Ser Ile Ile Ala Lys Lys Glu Val Leu Leu Asp Gln Pro Gly Arg 
    290                 295                 300                 


Glu Ala Pro Leu Pro Pro Pro His Ile Ala Thr Cys Ala Ala Ser Glu 
305                 310                 315                 320 


Pro Ser Pro Pro Ala Glu Glu Asn Gly Ser Thr Ser Lys Thr Ile Val 
                325                 330                 335     


Tyr His Leu Asp Glu Gly Val Tyr Gly Ile Phe Asn Ser Val Leu Phe 
            340                 345                 350         


Asp Asn Ile Cys Pro Thr Pro Ile Leu Gln Lys Lys Pro Ser Thr Glu 
        355                 360                 365             


Gln Pro Leu Tyr Ser Ser Ser Leu Trp Gly Pro Ala Val Asp Gly Cys 
    370                 375                 380                 


Asp Cys Val Ala Glu Gly Leu Trp Leu Pro Gln Leu His Val Gly Asp 
385                 390                 395                 400 


Trp Leu Val Phe Asp Asn Met Gly Ala Tyr Thr Val Gly Met Gly Ser 
                405                 410                 415     


Pro Phe Trp Gly Thr Gln Ala Cys His Ile Thr Tyr Ala Met Ser Arg 
            420                 425                 430         


Val Ala Trp Glu Ala Leu Arg Arg Gln Leu Met Ala Ala Glu Gln Glu 
        435                 440                 445             


Asp Asp Val Glu Gly Val Cys Lys Pro Leu Ser Cys Gly Trp Glu Ile 
    450                 455                 460                 


Thr Asp Thr Leu Cys Val Gly Pro Val Phe Thr Pro Ala Ser Ile Met 
465                 470                 475                 480 


<210> 6358
<211> 460
<212> PRT
<213> Homo sapiens

<400> 6358
Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ala Glu Met 
                85                  90                  95      


Glu Leu Val Gln His Ile Gly Ile Pro Ala Ser Lys Ile Ile Cys Ala 
            100                 105                 110         


Asn Pro Cys Lys Gln Ile Ala Gln Ile Lys Tyr Ala Ala Lys His Gly 
        115                 120                 125             


Ile Gln Leu Leu Ser Phe Asp Asn Glu Met Glu Leu Ala Lys Val Val 
    130                 135                 140                 


Lys Ser His Pro Ser Ala Lys Met Val Leu Cys Ile Ala Thr Asp Asp 
145                 150                 155                 160 


Ser His Ser Leu Ser Cys Leu Ser Leu Lys Phe Gly Val Ser Leu Lys 
                165                 170                 175     


Ser Cys Arg His Leu Leu Glu Asn Ala Lys Lys His His Val Glu Val 
            180                 185                 190         


Val Gly Val Ser Phe His Ile Gly Ser Gly Cys Pro Asp Pro Gln Ala 
        195                 200                 205             


Tyr Ala Gln Ser Ile Ala Asp Ala Arg Leu Val Phe Glu Met Gly Thr 
    210                 215                 220                 


Glu Leu Gly His Lys Met His Val Leu Asp Leu Gly Gly Gly Phe Pro 
225                 230                 235                 240 


Gly Thr Glu Gly Ala Lys Val Arg Phe Glu Glu Ile Ala Ser Val Ile 
                245                 250                 255     


Asn Ser Ala Leu Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val Asp Ile 
            260                 265                 270         


Phe Ala Glu Leu Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr Val Ala 
        275                 280                 285             


Val Ser Ile Ile Ala Lys Lys Glu Val Leu Leu Asp Gln Pro Gly Arg 
    290                 295                 300                 


Glu Glu Glu Asn Gly Ser Thr Ser Lys Thr Ile Val Tyr His Leu Asp 
305                 310                 315                 320 


Glu Gly Val Tyr Gly Ile Phe Asn Ser Val Leu Phe Asp Asn Ile Cys 
                325                 330                 335     


Pro Thr Pro Ile Leu Gln Lys Lys Pro Ser Thr Glu Gln Pro Leu Tyr 
            340                 345                 350         


Ser Ser Ser Leu Trp Gly Pro Ala Val Asp Gly Cys Asp Cys Val Ala 
        355                 360                 365             


Glu Gly Leu Trp Leu Pro Gln Leu His Val Gly Asp Trp Leu Val Phe 
    370                 375                 380                 


Asp Asn Met Gly Ala Tyr Thr Val Gly Met Gly Ser Pro Phe Trp Gly 
385                 390                 395                 400 


Thr Gln Ala Cys His Ile Thr Tyr Ala Met Ser Arg Val Ala Trp Glu 
                405                 410                 415     


Ala Leu Arg Arg Gln Leu Met Ala Ala Glu Gln Glu Asp Asp Val Glu 
            420                 425                 430         


Gly Val Cys Lys Pro Leu Ser Cys Gly Trp Glu Ile Thr Asp Thr Leu 
        435                 440                 445             


Cys Val Gly Pro Val Phe Thr Pro Ala Ser Ile Met 
    450                 455                 460 


<210> 6359
<211> 835
<212> PRT
<213> Homo sapiens

<400> 6359
Met Lys Arg Arg Thr Asp Pro Glu Cys Thr Ala Pro Ile Lys Lys Gln 
1               5                   10                  15      


Lys Lys Arg Val Ala Glu Leu Ala Leu Ser Leu Ser Ser Thr Ser Asp 
            20                  25                  30          


Asp Glu Pro Pro Ser Ser Val Ser His Gly Ala Lys Ala Ser Thr Thr 
        35                  40                  45              


Ser Leu Ser Gly Ser Asp Ser Glu Thr Glu Gly Lys Gln His Ser Ser 
    50                  55                  60                  


Asp Ser Phe Asp Asp Ala Phe Lys Ala Asp Ser Leu Val Glu Gly Thr 
65                  70                  75                  80  


Ser Ser Arg Tyr Ser Met Tyr Asn Ser Val Ser Gln Lys Leu Met Ala 
                85                  90                  95      


Lys Met Gly Phe Arg Glu Gly Glu Gly Leu Gly Lys Tyr Ser Gln Gly 
            100                 105                 110         


Arg Lys Asp Ile Val Glu Ala Ser Ser Gln Lys Gly Arg Arg Gly Leu 
        115                 120                 125             


Gly Leu Thr Leu Arg Gly Phe Asp Gln Glu Leu Asn Val Asp Trp Arg 
    130                 135                 140                 


Asp Glu Pro Glu Pro Ser Ala Cys Glu Gln Val Ser Trp Phe Pro Glu 
145                 150                 155                 160 


Cys Thr Thr Glu Ile Pro Asp Thr Gln Glu Met Ser Asp Trp Met Val 
                165                 170                 175     


Val Gly Lys Arg Lys Met Ile Ile Glu Asp Glu Thr Glu Phe Cys Gly 
            180                 185                 190         


Glu Glu Leu Leu His Ser Val Leu Gln Cys Lys Ser Val Phe Asp Val 
        195                 200                 205             


Leu Asp Gly Glu Glu Met Arg Arg Ala Arg Thr Arg Ala Asn Pro Tyr 
    210                 215                 220                 


Glu Met Ile Arg Gly Val Phe Phe Leu Asn Arg Ala Ala Met Lys Met 
225                 230                 235                 240 


Ala Asn Met Asp Phe Val Phe Asp Arg Met Phe Thr Asn Pro Arg Asp 
                245                 250                 255     


Ser Tyr Gly Lys Pro Leu Val Lys Asp Arg Glu Ala Glu Leu Leu Tyr 
            260                 265                 270         


Phe Ala Asp Val Cys Ala Gly Pro Gly Gly Phe Ser Glu Tyr Val Leu 
        275                 280                 285             


Trp Arg Lys Lys Trp His Ala Lys Gly Phe Gly Met Thr Leu Lys Gly 
    290                 295                 300                 


Pro Asn Asp Phe Lys Leu Glu Asp Phe Tyr Ser Ala Ser Ser Glu Leu 
305                 310                 315                 320 


Phe Glu Pro Tyr Tyr Gly Glu Gly Gly Ile Asp Gly Asp Gly Asp Ile 
                325                 330                 335     


Thr Arg Pro Glu Asn Ile Ser Ala Phe Arg Asn Phe Val Leu Asp Asn 
            340                 345                 350         


Thr Asp Arg Lys Gly Val His Phe Leu Met Ala Asp Gly Gly Phe Ser 
        355                 360                 365             


Val Glu Gly Gln Glu Asn Leu Gln Glu Ile Leu Ser Lys Gln Leu Leu 
    370                 375                 380                 


Leu Cys Gln Phe Leu Met Ala Leu Ser Ile Val Arg Thr Gly Gly His 
385                 390                 395                 400 


Phe Ile Cys Lys Thr Phe Asp Leu Phe Thr Pro Phe Ser Val Gly Leu 
                405                 410                 415     


Val Tyr Leu Leu Tyr Cys Cys Phe Glu Arg Val Cys Leu Phe Lys Pro 
            420                 425                 430         


Ile Thr Ser Arg Pro Ala Asn Ser Glu Arg Tyr Val Val Cys Lys Gly 
        435                 440                 445             


Leu Lys Val Gly Ile Asp Asp Val Arg Asp Tyr Leu Phe Ala Val Asn 
    450                 455                 460                 


Ile Lys Leu Asn Gln Leu Arg Asn Thr Asp Ser Asp Val Asn Leu Val 
465                 470                 475                 480 


Val Pro Leu Glu Val Ile Lys Gly Asp His Glu Phe Thr Asp Tyr Met 
                485                 490                 495     


Ile Arg Ser Asn Glu Ser His Cys Ser Leu Gln Ile Lys Ala Leu Ala 
            500                 505                 510         


Lys Ile His Ala Phe Val Gln Asp Thr Thr Leu Ser Glu Pro Arg Gln 
        515                 520                 525             


Ala Glu Ile Arg Lys Glu Cys Leu Arg Leu Trp Gly Ile Pro Asp Gln 
    530                 535                 540                 


Ala Arg Val Ala Pro Ser Ser Ser Asp Pro Lys Ser Lys Phe Phe Glu 
545                 550                 555                 560 


Leu Ile Gln Gly Thr Glu Ile Asp Ile Phe Ser Tyr Lys Pro Thr Leu 
                565                 570                 575     


Leu Thr Ser Lys Thr Leu Glu Lys Ile Arg Pro Val Phe Asp Tyr Arg 
            580                 585                 590         


Cys Met Val Ser Gly Ser Glu Gln Lys Phe Leu Ile Gly Leu Gly Lys 
        595                 600                 605             


Ser Gln Ile Tyr Thr Trp Asp Gly Arg Gln Ser Asp Arg Trp Ile Lys 
    610                 615                 620                 


Leu Asp Leu Lys Thr Glu Leu Pro Arg Asp Thr Leu Leu Ser Val Glu 
625                 630                 635                 640 


Ile Val His Glu Leu Lys Gly Glu Gly Lys Ala Gln Arg Lys Ile Ser 
                645                 650                 655     


Ala Ile His Ile Leu Asp Val Leu Val Leu Asn Gly Thr Asp Val Arg 
            660                 665                 670         


Glu Gln His Phe Asn Gln Arg Ile Gln Leu Ala Glu Lys Phe Val Lys 
        675                 680                 685             


Ala Val Ser Lys Pro Ser Arg Pro Asp Met Asn Pro Ile Arg Val Lys 
    690                 695                 700                 


Glu Val Tyr Arg Leu Glu Glu Met Glu Lys Ile Phe Val Arg Leu Glu 
705                 710                 715                 720 


Met Lys Ile Ile Lys Gly Ser Ser Gly Thr Pro Lys Leu Ser Tyr Thr 
                725                 730                 735     


Gly Arg Asp Asp Arg His Phe Val Pro Met Gly Leu Tyr Ile Val Arg 
            740                 745                 750         


Thr Val Asn Glu Pro Trp Thr Met Gly Phe Ser Lys Ser Phe Lys Lys 
        755                 760                 765             


Lys Phe Phe Tyr Asn Lys Lys Thr Lys Asp Ser Thr Phe Asp Leu Pro 
    770                 775                 780                 


Ala Asp Ser Ile Ala Pro Phe His Ile Cys Tyr Tyr Gly Arg Leu Phe 
785                 790                 795                 800 


Trp Glu Trp Gly Asp Gly Ile Arg Val His Asp Ser Gln Lys Pro Gln 
                805                 810                 815     


Asp Gln Asp Lys Leu Ser Lys Glu Asp Val Leu Ser Phe Ile Gln Met 
            820                 825                 830         


His Arg Ala 
        835 


<210> 6360
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6360
Xaa Gln Glu Leu Leu Lys Glu Lys Thr Leu Ala Glu Gln Asn Leu Glu 
1               5                   10                  15      


Asp Thr Arg Gln Gln Leu Leu Ala Ala Arg Ser Ser Gln Ala Lys Ala 
            20                  25                  30          


Ile Asn Thr Leu Glu Thr Arg Val Arg Glu Leu Glu Gln Thr Leu Gln 
        35                  40                  45              


Ala Ser Glu Glu Gln Leu Gln Gln Ser Lys Gly Ile Val Ala Ala Gln 
    50                  55                  60                  


Glu Thr Gln Ile Gln Glu Leu Val Ser Ala Tyr Trp Ser Cys Cys Ile 
65                  70                  75                  80  


Pro Gly Pro 
            


<210> 6361
<211> 767
<212> PRT
<213> Homo sapiens

<400> 6361
Met Phe Ala Lys Leu Lys Lys Lys Ile Ala Glu Glu Thr Ala Val Ala 
1               5                   10                  15      


Gln Arg Pro Gly Gly Ala Thr Arg Ile Pro Arg Ser Val Ser Lys Glu 
            20                  25                  30          


Ser Val Ala Ser Met Gly Ala Asp Ser Gly Asp Asp Phe Ala Ser Asp 
        35                  40                  45              


Gly Ser Ser Ser Arg Glu Asp Leu Ser Ser Gln Leu Leu Arg Arg Asn 
    50                  55                  60                  


Glu Gln Ile Arg Lys Leu Glu Ala Arg Leu Ser Asp Tyr Ala Glu Gln 
65                  70                  75                  80  


Val Arg Asn Leu Gln Lys Ile Lys Glu Lys Leu Glu Ile Ala Leu Glu 
                85                  90                  95      


Lys His Gln Asp Ser Ser Met Arg Lys Phe Gln Glu Gln Asn Glu Thr 
            100                 105                 110         


Phe Gln Ala Asn Arg Ala Lys Met Ala Glu Gly Leu Ala Leu Ala Leu 
        115                 120                 125             


Ala Arg Lys Asp Gln Glu Trp Ser Glu Lys Met Asp Gln Leu Glu Lys 
    130                 135                 140                 


Glu Lys Asn Ile Leu Thr Ala Gln Leu Gln Glu Met Lys Asn Gln Ser 
145                 150                 155                 160 


Met Asn Leu Phe Gln Arg Arg Asp Glu Met Asp Glu Leu Glu Gly Phe 
                165                 170                 175     


Gln Gln Gln Glu Leu Ser Lys Ile Lys His Met Leu Leu Lys Lys Glu 
            180                 185                 190         


Glu Ser Leu Gly Lys Met Glu Gln Glu Leu Glu Ala Arg Thr Arg Glu 
        195                 200                 205             


Leu Ser Arg Thr Gln Glu Glu Leu Met Asn Ser Asn Gln Met Ser Ser 
    210                 215                 220                 


Asp Leu Ser Gln Lys Leu Glu Glu Leu Gln Arg His Tyr Ser Thr Leu 
225                 230                 235                 240 


Glu Glu Gln Arg Asp His Val Ile Ala Ser Lys Thr Gly Ala Glu Ser 
                245                 250                 255     


Lys Ile Thr Ala Leu Glu Gln Lys Glu Gln Glu Leu Gln Ala Leu Ile 
            260                 265                 270         


Gln Gln Leu Ser Ile Asp Leu Gln Lys Val Thr Ala Glu Thr Gln Glu 
        275                 280                 285             


Lys Glu Asp Val Ile Thr His Leu Gln Glu Lys Val Ala Ser Leu Glu 
    290                 295                 300                 


Lys Arg Leu Glu Gln Asn Leu Ser Gly Glu Glu His Leu Gln Glu Leu 
305                 310                 315                 320 


Leu Lys Glu Lys Thr Leu Ala Glu Gln Asn Leu Glu Asp Thr Arg Gln 
                325                 330                 335     


Gln Leu Leu Ala Ala Arg Ser Ser Gln Ala Lys Ala Ile Asn Thr Leu 
            340                 345                 350         


Glu Thr Arg Val Arg Glu Leu Glu Gln Thr Leu Gln Ala Ser Glu Glu 
        355                 360                 365             


Gln Leu Gln Gln Ser Lys Gly Ile Val Ala Ala Gln Glu Thr Gln Ile 
    370                 375                 380                 


Gln Glu Leu Ala Ala Ala Asn Gln Glu Ser Ser His Val Gln Gln Gln 
385                 390                 395                 400 


Ala Leu Ala Leu Glu Gln Gln Phe Leu Glu Arg Thr Gln Ala Leu Glu 
                405                 410                 415     


Ala Gln Ile Val Ala Leu Glu Arg Thr Arg Ala Ala Asp Gln Thr Thr 
            420                 425                 430         


Ala Glu Gln Gly Met Arg Gln Leu Glu Gln Glu Asn Ala Ala Leu Lys 
        435                 440                 445             


Glu Cys Arg Asn Glu Tyr Glu Arg Ser Leu Gln Asn His Gln Phe Glu 
    450                 455                 460                 


Leu Lys Lys Leu Lys Glu Glu Trp Ser Gln Arg Glu Ile Val Ser Val 
465                 470                 475                 480 


Ala Met Ala Gln Ala Leu Glu Glu Val Arg Lys Gln Arg Glu Glu Phe 
                485                 490                 495     


Gln Gln Gln Ala Ala Asn Leu Thr Ala Ile Ile Asp Glu Lys Glu Gln 
            500                 505                 510         


Asn Leu Arg Glu Lys Thr Glu Val Leu Leu Gln Lys Glu Gln Glu Ile 
        515                 520                 525             


Leu Gln Leu Glu Arg Gly His Asn Ser Ala Leu Leu Gln Ile His Gln 
    530                 535                 540                 


Leu Gln Ala Glu Leu Glu Ala Leu Arg Thr Leu Lys Ala Glu Glu Ala 
545                 550                 555                 560 


Ala Val Val Ala Glu Gln Glu Asp Leu Leu Arg Leu Arg Gly Pro Leu 
                565                 570                 575     


Gln Ala Glu Ala Leu Ser Val Asn Glu Ser His Val Thr Ser Arg Ala 
            580                 585                 590         


Met Gln Asp Pro Val Phe Gln Leu Pro Thr Ala Gly Arg Thr Pro Asn 
        595                 600                 605             


Gly Glu Val Gly Ala Met Asp Leu Thr Gln Leu Gln Lys Glu Lys Gln 
    610                 615                 620                 


Asp Leu Glu Gln Gln Leu Leu Glu Lys Asn Lys Thr Ile Lys Gln Met 
625                 630                 635                 640 


Gln Gln Arg Met Leu Glu Leu Arg Lys Thr Leu Gln Lys Glu Leu Lys 
                645                 650                 655     


Ile Arg Pro Asp Asn Glu Leu Phe Glu Val Arg Glu Lys Pro Gly Pro 
            660                 665                 670         


Glu Met Ala Asn Met Ala Pro Ser Val Thr Asn Asn Thr Asp Leu Thr 
        675                 680                 685             


Asp Ala Arg Glu Ile Asn Phe Glu Tyr Leu Lys His Val Val Leu Lys 
    690                 695                 700                 


Phe Met Ser Cys Arg Glu Ser Glu Ala Phe His Leu Ile Lys Ala Val 
705                 710                 715                 720 


Ser Val Leu Leu Asn Phe Ser Gln Glu Glu Glu Asn Met Leu Lys Glu 
                725                 730                 735     


Thr Leu Glu Tyr Lys Met Ser Trp Phe Gly Ser Lys Pro Ala Pro Lys 
            740                 745                 750         


Gly Ser Ile Arg Pro Ser Ile Ser Asn Pro Arg Ile Pro Trp Ser 
        755                 760                 765         


<210> 6362
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6362
Xaa Ala Lys Ile Lys Ala Arg Asp Leu Arg Gly Lys Lys Lys Glu Glu 
1               5                   10                  15      


Leu Leu Lys Gln Leu Asp Asp Leu Lys Val Glu Leu Ser Gln Leu Arg 
            20                  25                  30          


Val Ala Lys Val Thr Gly Gly Ala Ala Ser Lys Leu Ser Lys Ile Arg 
        35                  40                  45              


Val Val Arg Lys Ser Ile Ala Arg Val Leu Thr Val Ile Asn Gln Thr 
    50                  55                  60                  


Gln Lys Glu Asn Leu Arg Lys Phe Tyr Lys Ala Ala Ala Gly Gly Pro 
65                  70                  75                  80  


Cys Ile Gln Met Asp Arg Val Leu Pro Gln Pro Pro Ala Cys Ser Cys 
                85                  90                  95      


<210> 6363
<211> 344
<212> PRT
<213> Homo sapiens

<400> 6363
Met Arg Arg Arg Arg Glu Glu Glu Gly Ile Gln Leu Arg Lys Gln Lys 
1               5                   10                  15      


Arg Glu Gln Gln Leu Phe Lys Arg Arg Asn Val Glu Leu Ile Asn Glu 
            20                  25                  30          


Glu Ala Ala Met Phe Asp Ser Leu Leu Met Asp Ser Tyr Val Ser Ser 
        35                  40                  45              


Thr Thr Gly Glu Ser Val Ile Thr Arg Glu Met Val Glu Met Leu Phe 
    50                  55                  60                  


Ser Asp Asp Ser Asp Leu Gln Leu Ala Thr Thr Gln Lys Phe Arg Lys 
65                  70                  75                  80  


Leu Leu Ser Lys Glu Pro Ser Pro Pro Ile Asp Glu Val Ile Asn Thr 
                85                  90                  95      


Pro Arg Val Val Asp Arg Phe Val Glu Phe Leu Lys Arg Asn Glu Asn 
            100                 105                 110         


Cys Thr Leu Gln Ala Val Trp Ala Leu Gly Asn Ile Ala Gly Asp Ser 
        115                 120                 125             


Ser Val Cys Arg Asp Tyr Val Leu Asn Cys Ser Ile Leu Asn Pro Leu 
    130                 135                 140                 


Leu Thr Leu Leu Thr Lys Ser Thr Arg Leu Thr Met Thr Arg Asn Ala 
145                 150                 155                 160 


Val Trp Ala Leu Ser Asn Leu Cys Arg Gly Lys Asn Pro Pro Pro Glu 
                165                 170                 175     


Phe Ala Lys Val Ser Pro Cys Leu Pro Val Leu Ser Arg Leu Leu Phe 
            180                 185                 190         


Ser Ser Asp Ser Asp Leu Leu Ala Asp Ala Cys Trp Ala Leu Ser Tyr 
        195                 200                 205             


Leu Ser Asp Gly Pro Asn Glu Lys Ile Gln Ala Val Ile Asp Ser Gly 
    210                 215                 220                 


Val Cys Arg Arg Leu Val Glu Leu Leu Met His Asn Asp Tyr Lys Val 
225                 230                 235                 240 


Ala Ser Pro Ala Leu Arg Ala Val Gly Asn Ile Val Thr Gly Asp Asp 
                245                 250                 255     


Ile Gln Thr Gln Val Ile Leu Asn Cys Ser Ala Leu Pro Cys Leu Leu 
            260                 265                 270         


His Leu Leu Ser Ser Pro Lys Glu Ser Ile Arg Lys Glu Ala Cys Trp 
        275                 280                 285             


Thr Ile Ser Asn Ile Thr Ala Gly Asn Arg Ala Gln Ile Gln Ala Val 
    290                 295                 300                 


Ile Asp Ala Asn Ile Phe Pro Val Leu Ile Glu Ile Leu Gln Lys Ala 
305                 310                 315                 320 


Glu Phe Arg Thr Arg Lys Glu Ala Ala Trp Ala Ile Thr Asn Ala Thr 
                325                 330                 335     


Ser Gly Gly Thr Pro Glu Gln Ile 
            340                 


<210> 6364
<211> 193
<212> PRT
<213> Homo sapiens

<400> 6364
Met Pro Thr Thr Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Thr Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser 
    50                  55                  60                  


Ser Gly Ser Pro Ile Gly Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro 
65                  70                  75                  80  


Pro Ser Phe Asn Leu His Pro Ala Pro His Leu Leu Ala Ser Met His 
                85                  90                  95      


Leu Gln Lys Leu Asn Ser Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro 
            100                 105                 110         


Gly Gln Pro Gly Glu Ala Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala 
        115                 120                 125             


Gln Ala Gly Gly Ala Glu Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser 
    130                 135                 140                 


Pro Ala Ile Ile Asp Ser Asp Pro Val Asp Glu Glu Val Leu Met Ser 
145                 150                 155                 160 


Leu Val Val Glu Leu Gly Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu 
                165                 170                 175     


Trp Leu Gly Gln Asn Glu Phe Asp Phe Thr Ala Asp Phe Pro Ser Ser 
            180                 185                 190         


Cys 
    


<210> 6365
<211> 536
<212> PRT
<213> Homo sapiens

<400> 6365
Met Glu Thr Met Ala Ser Pro Gly Lys Asp Asn Tyr Arg Met Lys Ser 
1               5                   10                  15      


Tyr Lys Asn Asn Ala Leu Asn Pro Glu Glu Met Arg Arg Arg Arg Glu 
            20                  25                  30          


Glu Glu Gly Ile Gln Leu Arg Lys Gln Lys Arg Glu Gln Gln Leu Phe 
        35                  40                  45              


Lys Arg Arg Asn Val Glu Leu Ile Asn Glu Glu Ala Ala Met Phe Asp 
    50                  55                  60                  


Ser Leu Leu Met Asp Ser Tyr Val Ser Ser Thr Thr Gly Glu Ser Val 
65                  70                  75                  80  


Ile Thr Arg Glu Met Val Glu Met Leu Phe Ser Asp Asp Ser Asp Leu 
                85                  90                  95      


Gln Leu Ala Thr Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys Glu Pro 
            100                 105                 110         


Ser Pro Pro Ile Asp Glu Val Ile Asn Thr Pro Arg Val Val Asp Arg 
        115                 120                 125             


Phe Val Glu Phe Leu Lys Arg Asn Glu Asn Cys Thr Leu Gln Phe Glu 
    130                 135                 140                 


Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser Gly Thr Ser Gln Gln Thr 
145                 150                 155                 160 


Lys Ile Val Ile Glu Ala Gly Ala Val Pro Ile Phe Ile Glu Leu Leu 
                165                 170                 175     


Asn Ser Asp Phe Glu Asp Val Gln Glu Gln Ala Val Trp Ala Leu Gly 
            180                 185                 190         


Asn Ile Ala Gly Asp Ser Ser Val Cys Arg Asp Tyr Val Leu Asn Cys 
        195                 200                 205             


Ser Ile Leu Asn Pro Leu Leu Thr Leu Leu Thr Lys Ser Thr Arg Leu 
    210                 215                 220                 


Thr Met Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu Cys Arg Gly 
225                 230                 235                 240 


Lys Asn Pro Pro Pro Glu Phe Ala Lys Val Ser Pro Cys Leu Pro Val 
                245                 250                 255     


Leu Ser Arg Leu Leu Phe Ser Ser Asp Ser Asp Leu Leu Ala Asp Ala 
            260                 265                 270         


Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Glu Lys Ile Gln 
        275                 280                 285             


Ala Val Ile Asp Ser Gly Val Cys Arg Arg Leu Val Glu Leu Leu Met 
    290                 295                 300                 


His Asn Asp Tyr Lys Val Ala Ser Pro Ala Leu Arg Ala Val Gly Asn 
305                 310                 315                 320 


Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu Asn Cys Ser 
                325                 330                 335     


Ala Leu Pro Cys Leu Leu His Leu Leu Ser Ser Pro Lys Glu Ser Ile 
            340                 345                 350         


Arg Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala Gly Asn Arg 
        355                 360                 365             


Ala Gln Ile Gln Ala Val Ile Asp Ala Asn Ile Phe Pro Val Leu Ile 
    370                 375                 380                 


Glu Ile Leu Gln Lys Ala Glu Phe Arg Thr Arg Lys Glu Ala Ala Trp 
385                 390                 395                 400 


Ala Ile Thr Asn Ala Thr Ser Gly Gly Thr Pro Glu Gln Ile Arg Tyr 
                405                 410                 415     


Leu Val Ser Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu Thr Val 
            420                 425                 430         


Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu Asn Ile 
        435                 440                 445             


Leu Arg Leu Gly Glu Gln Glu Gly Lys Arg Ser Gly Ser Gly Val Asn 
    450                 455                 460                 


Pro Tyr Cys Gly Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys Ile Glu 
465                 470                 475                 480 


Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala Phe Asp 
                485                 490                 495     


Leu Ile Glu His Tyr Phe Gly Val Glu Asp Asp Asp Ser Ser Leu Ala 
            500                 505                 510         


Pro Gln Val Asp Glu Thr Gln Gln Gln Phe Ile Phe Gln Gln Pro Glu 
        515                 520                 525             


Ala Pro Met Glu Gly Phe Gln Leu 
    530                 535     


<210> 6366
<211> 922
<212> PRT
<213> Homo sapiens

<400> 6366
Met Ile Thr Ser Ala Ala Gly Ile Ile Ser Leu Leu Asp Glu Asp Glu 
1               5                   10                  15      


Pro Gln Leu Lys Glu Phe Ala Leu His Lys Leu Asn Ala Val Val Asn 
            20                  25                  30          


Asp Phe Trp Ala Glu Ile Ser Glu Ser Val Asp Lys Ile Glu Val Leu 
        35                  40                  45              


Tyr Glu Asp Glu Gly Phe Arg Ser Arg Gln Phe Ala Ala Leu Val Ala 
    50                  55                  60                  


Ser Lys Val Phe Tyr His Leu Gly Ala Phe Glu Glu Ser Leu Asn Tyr 
65                  70                  75                  80  


Ala Leu Gly Ala Gly Asp Leu Phe Asn Val Asn Asp Asn Ser Glu Tyr 
                85                  90                  95      


Val Glu Thr Ile Ile Ala Lys Cys Ile Asp His Tyr Thr Lys Gln Cys 
            100                 105                 110         


Val Glu Asn Ala Asp Leu Pro Glu Gly Glu Lys Lys Pro Ile Asp Gln 
        115                 120                 125             


Arg Leu Glu Gly Ile Val Asn Lys Met Phe Gln Arg Cys Leu Asp Asp 
    130                 135                 140                 


His Lys Tyr Lys Gln Ala Ile Gly Ile Ala Leu Glu Thr Arg Arg Leu 
145                 150                 155                 160 


Asp Val Phe Glu Lys Thr Ile Leu Glu Ser Asn Asp Val Pro Gly Met 
                165                 170                 175     


Leu Ala Tyr Ser Leu Lys Leu Cys Met Ser Leu Met Gln Asn Lys Gln 
            180                 185                 190         


Phe Arg Asn Lys Val Leu Arg Val Leu Val Lys Ile Tyr Met Asn Leu 
        195                 200                 205             


Glu Lys Pro Asp Phe Ile Asn Val Cys Gln Cys Leu Ile Phe Leu Asp 
    210                 215                 220                 


Asp Pro Gln Ala Val Ser Asp Ile Leu Glu Lys Leu Val Lys Glu Asp 
225                 230                 235                 240 


Asn Leu Leu Met Ala Tyr Gln Ile Cys Phe Asp Leu Tyr Glu Ser Ala 
                245                 250                 255     


Ser Gln Gln Phe Leu Ser Ser Val Ile Gln Asn Leu Arg Thr Val Gly 
            260                 265                 270         


Thr Pro Ile Ala Ser Val Pro Gly Ser Thr Asn Thr Gly Thr Val Pro 
        275                 280                 285             


Gly Ser Glu Lys Asp Ser Asp Ser Met Glu Thr Glu Glu Lys Thr Ser 
    290                 295                 300                 


Ser Ala Phe Val Gly Lys Thr Pro Glu Ala Ser Pro Glu Pro Lys Asp 
305                 310                 315                 320 


Gln Thr Leu Lys Met Ile Lys Ile Leu Ser Gly Glu Met Ala Ile Glu 
                325                 330                 335     


Leu His Leu Gln Phe Leu Ile Arg Asn Asn Asn Thr Asp Leu Met Ile 
            340                 345                 350         


Leu Lys Asn Thr Lys Asp Ala Val Arg Asn Ser Val Cys His Thr Ala 
        355                 360                 365             


Thr Val Ile Ala Asn Ser Phe Met His Cys Gly Thr Thr Ser Asp Gln 
    370                 375                 380                 


Phe Leu Arg Asp Asn Leu Glu Trp Leu Ala Arg Ala Thr Asn Trp Ala 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Ala Ser Leu Gly Val Ile His Lys Gly His Glu 
                405                 410                 415     


Lys Glu Ala Leu Gln Leu Met Ala Thr Tyr Leu Pro Lys Asp Thr Ser 
            420                 425                 430         


Pro Gly Ser Ala Tyr Gln Glu Gly Gly Gly Leu Tyr Ala Leu Gly Leu 
        435                 440                 445             


Ile His Ala Asn His Gly Gly Asp Ile Ile Asp Tyr Leu Leu Asn Gln 
    450                 455                 460                 


Leu Lys Asn Ala Ser Asn Asp Ile Val Arg His Gly Gly Ser Leu Gly 
465                 470                 475                 480 


Leu Gly Leu Ala Ala Met Gly Thr Ala Arg Gln Asp Val Tyr Asp Leu 
                485                 490                 495     


Leu Lys Thr Asn Leu Tyr Gln Asp Asp Ala Val Thr Gly Glu Ala Ala 
            500                 505                 510         


Gly Leu Ala Leu Gly Leu Val Met Leu Gly Ser Lys Asn Ala Gln Ala 
        515                 520                 525             


Ile Glu Asp Met Val Gly Tyr Ala Gln Glu Thr Gln His Glu Lys Ile 
    530                 535                 540                 


Leu Arg Gly Leu Ala Val Gly Ile Ala Leu Val Met Tyr Gly Arg Met 
545                 550                 555                 560 


Glu Glu Ala Asp Ala Leu Ile Glu Ser Leu Cys Arg Asp Lys Asp Pro 
                565                 570                 575     


Ile Leu Arg Arg Ser Gly Met Tyr Thr Val Ala Met Ala Tyr Cys Gly 
            580                 585                 590         


Ser Gly Asn Asn Lys Ala Ile Arg Arg Leu Leu His Val Ala Val Ser 
        595                 600                 605             


Asp Val Asn Asp Asp Val Arg Arg Ala Ala Val Glu Ser Leu Gly Phe 
    610                 615                 620                 


Ile Leu Phe Arg Thr Pro Glu Gln Cys Pro Ser Val Val Ser Leu Leu 
625                 630                 635                 640 


Ser Glu Ser Tyr Asn Pro His Val Arg Tyr Gly Ala Ala Met Ala Leu 
                645                 650                 655     


Gly Ile Cys Cys Ala Gly Thr Gly Asn Lys Glu Ala Ile Asn Leu Leu 
            660                 665                 670         


Glu Pro Met Thr Asn Asp Pro Val Asn Tyr Val Arg Gln Gly Ala Leu 
        675                 680                 685             


Ile Ala Ser Ala Leu Ile Met Ile Gln Gln Thr Glu Ile Thr Cys Pro 
    690                 695                 700                 


Lys Val Asn Gln Phe Arg Gln Leu Tyr Ser Lys Val Ile Asn Asp Lys 
705                 710                 715                 720 


His Asp Asp Val Met Ala Lys Phe Gly Ala Ile Leu Ala Gln Gly Ile 
                725                 730                 735     


Leu Asp Ala Gly Gly His Asn Val Thr Ile Ser Leu Gln Ser Arg Thr 
            740                 745                 750         


Gly His Thr His Met Pro Ser Val Val Gly Val Leu Val Phe Thr Gln 
        755                 760                 765             


Phe Trp Phe Trp Phe Pro Leu Ser His Phe Leu Ser Leu Ala Tyr Thr 
    770                 775                 780                 


Pro Thr Cys Val Ile Gly Leu Asn Lys Asp Leu Lys Val Ser Thr Ala 
785                 790                 795                 800 


Val Leu Ser Ile Thr Ala Lys Ala Lys Lys Lys Glu Lys Glu Lys Glu 
                805                 810                 815     


Lys Lys Glu Glu Glu Lys Met Glu Val Asp Glu Ala Glu Lys Lys Glu 
            820                 825                 830         


Glu Lys Glu Lys Lys Lys Glu Pro Glu Pro Asn Phe Gln Leu Leu Asp 
        835                 840                 845             


Asn Pro Ala Arg Val Met Pro Ala Gln Leu Lys Val Leu Thr Met Pro 
    850                 855                 860                 


Glu Thr Cys Arg Tyr Gln Pro Phe Lys Pro Leu Ser Ile Gly Gly Ile 
865                 870                 875                 880 


Ile Ile Leu Lys Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro 
                885                 890                 895     


Val Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu 
            900                 905                 910         


Pro Pro Glu Pro Phe Glu Tyr Ile Asp Asp 
        915                 920         


<210> 6367
<211> 408
<212> PRT
<213> Homo sapiens

<400> 6367
Met Pro Glu Glu Gln Ala Phe Ser Val Leu Val Lys Ile Met Phe Asp 
1               5                   10                  15      


Tyr Gly Leu Arg Glu Leu Phe Lys Gln Asn Phe Glu Asp Leu His Cys 
            20                  25                  30          


Lys Phe Tyr Gln Leu Glu Arg Leu Met Gln Glu Tyr Ile Pro Asp Leu 
        35                  40                  45              


Tyr Asn His Phe Leu Asp Ile Ser Leu Glu Ala His Met Tyr Ala Ser 
    50                  55                  60                  


Gln Trp Phe Leu Thr Leu Phe Thr Ala Lys Phe Pro Leu Tyr Met Val 
65                  70                  75                  80  


Phe His Ile Ile Asp Leu Leu Leu Cys Glu Gly Ile Ser Val Ile Phe 
                85                  90                  95      


Asn Val Ala Leu Gly Leu Leu Lys Thr Ser Lys Asp Asp Leu Leu Leu 
            100                 105                 110         


Thr Asp Phe Glu Gly Ala Leu Lys Phe Phe Arg Val Gln Leu Pro Lys 
        115                 120                 125             


Arg Tyr Arg Ser Glu Glu Asn Ala Lys Lys Leu Met Glu Leu Ala Cys 
    130                 135                 140                 


Asn Met Lys Ile Ser Gln Lys Lys Leu Lys Lys Tyr Glu Lys Glu Tyr 
145                 150                 155                 160 


His Thr Met Arg Glu Gln Gln Ala Gln Gln Glu Asp Pro Ile Glu Arg 
                165                 170                 175     


Phe Glu Arg Glu Asn Arg Arg Leu Gln Glu Ala Asn Met Arg Leu Glu 
            180                 185                 190         


Gln Glu Asn Asp Asp Leu Ala His Glu Leu Val Thr Ser Lys Ile Ala 
        195                 200                 205             


Leu Arg Lys Asp Leu Asp Asn Ala Glu Glu Lys Ala Asp Ala Leu Asn 
    210                 215                 220                 


Lys Glu Leu Leu Met Thr Lys Gln Lys Leu Ile Asp Ala Glu Glu Glu 
225                 230                 235                 240 


Lys Arg Arg Leu Glu Glu Glu Ser Ala Gln Leu Lys Glu Met Cys Arg 
                245                 250                 255     


Arg Glu Leu Asp Lys Ala Glu Ser Glu Ile Lys Lys Asn Ser Ser Ile 
            260                 265                 270         


Ile Gly Asp Tyr Lys Gln Ile Cys Ser Gln Leu Ser Glu Arg Leu Glu 
        275                 280                 285             


Lys Gln Gln Thr Ala Asn Lys Val Glu Ile Glu Lys Ile Arg Gln Lys 
    290                 295                 300                 


Val Asp Asp Cys Glu Arg Cys Arg Glu Phe Phe Asn Lys Glu Gly Arg 
305                 310                 315                 320 


Val Lys Gly Ile Ser Ser Thr Lys Glu Val Leu Asp Glu Asp Thr Asp 
                325                 330                 335     


Glu Glu Lys Glu Thr Leu Lys Asn Gln Leu Arg Glu Met Glu Leu Glu 
            340                 345                 350         


Leu Ala Gln Thr Lys Leu Gln Leu Val Glu Ala Glu Cys Lys Ile Gln 
        355                 360                 365             


Asp Leu Glu His His Leu Gly Leu Ala Leu Asn Glu Val Gln Ala Ala 
    370                 375                 380                 


Lys Lys Thr Trp Phe Asn Arg Thr Leu Ser Ser Ile Lys Thr Ala Thr 
385                 390                 395                 400 


Gly Val Gln Gly Lys Glu Thr Cys 
                405             


<210> 6368
<211> 1069
<212> PRT
<213> Homo sapiens

<400> 6368
Met Asp Asp Lys Ala Ser Val Gly Lys Ile Ser Val Ser Ser Asp Ser 
1               5                   10                  15      


Val Ser Thr Leu Asn Ser Glu Asp Phe Val Leu Val Ser Arg Gln Gly 
            20                  25                  30          


Asp Glu Thr Pro Ser Thr Asn Asn Gly Ser Asp Asp Glu Lys Thr Gly 
        35                  40                  45              


Leu Lys Ile Val Gly Asn Gly Ser Glu Gln Gln Leu Gln Lys Glu Leu 
    50                  55                  60                  


Ala Asp Val Leu Met Asp Pro Pro Met Asp Asp Gln Pro Gly Glu Lys 
65                  70                  75                  80  


Glu Leu Val Lys Arg Ser Gln Leu Asp Gly Glu Gly Asp Gly Pro Leu 
                85                  90                  95      


Ser Asn Gln Leu Ser Ala Ser Ser Thr Ile Asn Pro Val Pro Leu Val 
            100                 105                 110         


Gly Leu Gln Lys Pro Glu Met Ser Leu Pro Val Lys Pro Gly Gln Gly 
        115                 120                 125             


Asp Ser Glu Ala Ser Ser Pro Phe Thr Pro Val Ala Asp Glu Asp Ser 
    130                 135                 140                 


Val Val Phe Ser Lys Leu Thr Tyr Leu Gly Cys Ala Ser Val Asn Ala 
145                 150                 155                 160 


Pro Arg Ser Glu Val Glu Ala Leu Arg Met Met Ser Ile Leu Arg Ser 
                165                 170                 175     


Gln Cys Gln Ile Ser Leu Asp Val Thr Leu Ser Val Pro Asn Val Ser 
            180                 185                 190         


Glu Gly Ile Val Arg Leu Leu Asp Pro Gln Thr Asn Thr Glu Ile Ala 
        195                 200                 205             


Asn Tyr Pro Ile Tyr Lys Ile Leu Phe Cys Val Arg Gly His Asp Gly 
    210                 215                 220                 


Thr Pro Glu Ser Asp Cys Phe Ala Phe Thr Glu Ser His Tyr Asn Ala 
225                 230                 235                 240 


Glu Leu Phe Arg Ile His Val Phe Arg Cys Glu Ile Gln Glu Ala Val 
                245                 250                 255     


Ser Arg Ile Leu Tyr Ser Phe Ala Thr Ala Phe Arg Arg Ser Ala Lys 
            260                 265                 270         


Gln Thr Pro Leu Ser Ala Thr Ala Ala Pro Gln Thr Pro Asp Ser Asp 
        275                 280                 285             


Ile Phe Thr Phe Ser Val Ser Leu Glu Ile Lys Glu Asp Asp Gly Lys 
    290                 295                 300                 


Gly Tyr Phe Ser Ala Val Pro Lys Asp Lys Asp Arg Gln Cys Phe Lys 
305                 310                 315                 320 


Leu Arg Gln Gly Ile Asp Lys Lys Ile Val Ile Tyr Val Gln Gln Thr 
                325                 330                 335     


Thr Asn Lys Glu Leu Ala Ile Glu Arg Cys Phe Gly Leu Leu Leu Ser 
            340                 345                 350         


Pro Gly Lys Asp Val Arg Asn Ser Asp Met His Leu Leu Asp Leu Glu 
        355                 360                 365             


Ser Met Gly Lys Ser Ser Asp Gly Lys Ser Tyr Val Ile Thr Gly Ser 
    370                 375                 380                 


Trp Asn Pro Lys Ser Pro His Phe Gln Val Val Asn Glu Glu Thr Pro 
385                 390                 395                 400 


Lys Asp Lys Val Leu Phe Met Thr Thr Ala Val Asp Leu Val Ile Thr 
                405                 410                 415     


Glu Val Gln Glu Pro Val Arg Phe Leu Leu Glu Thr Lys Val Arg Val 
            420                 425                 430         


Cys Ser Pro Asn Glu Arg Leu Phe Trp Pro Phe Ser Lys Arg Ser Thr 
        435                 440                 445             


Thr Glu Asn Phe Phe Leu Lys Leu Lys Gln Ile Lys Gln Arg Glu Arg 
    450                 455                 460                 


Lys Asn Asn Thr Asp Thr Leu Tyr Glu Val Val Cys Leu Glu Ser Glu 
465                 470                 475                 480 


Ser Glu Arg Glu Arg Arg Lys Thr Thr Ala Ser Pro Ser Val Arg Leu 
                485                 490                 495     


Pro Gln Ser Gly Ser Gln Ser Ser Val Ile Pro Ser Pro Pro Glu Asp 
            500                 505                 510         


Asp Glu Glu Glu Asp Asn Asp Glu Pro Leu Leu Ser Gly Ser Gly Asp 
        515                 520                 525             


Val Ser Lys Glu Cys Ala Glu Lys Ile Leu Glu Thr Trp Gly Glu Leu 
    530                 535                 540                 


Leu Ser Lys Trp His Leu Asn Leu Asn Val Arg Pro Lys Gln Leu Ser 
545                 550                 555                 560 


Ser Leu Val Arg Asn Gly Val Pro Glu Ala Leu Arg Gly Glu Val Trp 
                565                 570                 575     


Gln Leu Leu Ala Gly Cys His Asn Asn Asp His Leu Val Glu Lys Tyr 
            580                 585                 590         


Arg Ile Leu Ile Thr Lys Glu Ser Pro Gln Asp Ser Ala Ile Thr Arg 
        595                 600                 605             


Asp Ile Asn Arg Thr Phe Pro Ala His Asp Tyr Phe Lys Asp Thr Gly 
    610                 615                 620                 


Gly Asp Gly Gln Asp Ser Leu Tyr Lys Ile Cys Lys Ala Tyr Ser Val 
625                 630                 635                 640 


Tyr Asp Glu Glu Ile Gly Tyr Cys Gln Gly Gln Ser Phe Leu Ala Ala 
                645                 650                 655     


Val Leu Leu Leu His Met Pro Glu Glu Gln Ala Phe Ser Val Leu Val 
            660                 665                 670         


Lys Ile Met Phe Asp Tyr Gly Leu Arg Glu Leu Phe Lys Gln Asn Phe 
        675                 680                 685             


Glu Asp Leu His Cys Lys Phe Tyr Gln Leu Glu Arg Leu Met Gln Glu 
    690                 695                 700                 


Tyr Ile Pro Asp Leu Tyr Asn His Phe Leu Asp Ile Ser Leu Glu Ala 
705                 710                 715                 720 


His Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe Thr Ala Lys Phe 
                725                 730                 735     


Pro Leu Tyr Met Val Phe His Ile Ile Asp Leu Leu Leu Cys Glu Gly 
            740                 745                 750         


Ile Ser Val Ile Phe Asn Val Ala Leu Gly Leu Leu Lys Thr Ser Lys 
        755                 760                 765             


Asp Asp Leu Leu Leu Thr Asp Phe Glu Gly Ala Leu Lys Phe Phe Arg 
    770                 775                 780                 


Val Gln Leu Pro Lys Arg Tyr Arg Ser Glu Glu Asn Ala Lys Lys Leu 
785                 790                 795                 800 


Met Glu Leu Ala Cys Asn Met Lys Ile Ser Gln Lys Lys Leu Lys Lys 
                805                 810                 815     


Tyr Glu Lys Glu Tyr His Thr Met Arg Glu Gln Gln Ala Gln Gln Glu 
            820                 825                 830         


Asp Pro Ile Glu Arg Phe Glu Arg Glu Asn Arg Arg Leu Gln Glu Ala 
        835                 840                 845             


Asn Met Arg Leu Glu Gln Glu Asn Asp Asp Leu Ala His Glu Leu Val 
    850                 855                 860                 


Thr Ser Lys Ile Ala Leu Arg Lys Asp Leu Asp Asn Ala Glu Glu Lys 
865                 870                 875                 880 


Ala Asp Ala Leu Asn Lys Glu Leu Leu Met Thr Lys Gln Lys Leu Ile 
                885                 890                 895     


Asp Ala Glu Glu Glu Lys Arg Arg Leu Glu Glu Glu Ser Ala Gln Leu 
            900                 905                 910         


Lys Glu Met Cys Arg Arg Glu Leu Asp Lys Ala Glu Ser Glu Ile Lys 
        915                 920                 925             


Lys Asn Ser Ser Ile Ile Gly Asp Tyr Lys Gln Ile Cys Ser Gln Leu 
    930                 935                 940                 


Ser Glu Arg Leu Glu Lys Gln Gln Thr Ala Asn Lys Val Glu Ile Glu 
945                 950                 955                 960 


Lys Ile Arg Gln Lys Val Asp Asp Cys Glu Arg Cys Arg Glu Phe Phe 
                965                 970                 975     


Asn Lys Glu Gly Arg Val Lys Gly Ile Ser Ser Thr Lys Glu Val Leu 
            980                 985                 990         


Asp Glu Asp Thr Asp Glu Glu Lys  Glu Thr Leu Lys Asn  Gln Leu Arg 
        995                 1000                 1005             


Glu Met  Glu Leu Glu Leu Ala  Gln Thr Lys Leu Gln  Leu Val Glu 
    1010                 1015                 1020             


Ala Glu  Cys Lys Ile Gln Asp  Leu Glu His His Leu  Gly Leu Ala 
    1025                 1030                 1035             


Leu Asn  Glu Val Gln Ala Ala  Lys Lys Thr Trp Phe  Asn Arg Thr 
    1040                 1045                 1050             


Leu Ser  Ser Ile Lys Thr Ala  Thr Gly Val Gln Gly  Lys Glu Thr 
    1055                 1060                 1065             


Cys 
    


<210> 6369
<211> 935
<212> PRT
<213> Homo sapiens

<400> 6369
Met Gln Arg Lys Leu Val Thr Leu Val Asn Cys Gln Leu Val Glu Glu 
1               5                   10                  15      


Glu Gly Arg Val Arg Ala Met Arg Ala Ala Arg Ser Leu Gly Glu Arg 
            20                  25                  30          


Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro Gln Gln Leu Ser 
        35                  40                  45              


Ala Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys Gln Phe Leu Gly 
    50                  55                  60                  


Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu Leu Ala Leu Glu 
65                  70                  75                  80  


Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu Phe Val Val Gln 
                85                  90                  95      


Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr Ser Ile Gly His 
            100                 105                 110         


Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys Val Thr Lys Arg 
        115                 120                 125             


Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu Phe Arg Ser Tyr 
    130                 135                 140                 


Glu Ala Leu Arg Arg Glu His Asp Ala Gln Ile Val His Ile Ala Met 
145                 150                 155                 160 


Glu Ala Gly Leu Arg Ile Ser Pro Glu Gln Trp Ser Ser Leu Leu Tyr 
                165                 170                 175     


Gly Asp Leu Ala His Lys Ser His Met Gln Ser Ile Ile Asp Lys Leu 
            180                 185                 190         


Gln Ser Pro Glu Ser Phe Ala Lys Ser Val Gln Glu Leu Thr Ile Val 
        195                 200                 205             


Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg Leu Arg Pro His 
    210                 215                 220                 


Leu Glu Leu Leu Ala Asn Ile Asp Pro Asn Pro Asp Ala Val Ser Pro 
225                 230                 235                 240 


Thr Trp Glu Gln Leu Glu Asn Ala Met Val Ala Val Lys Thr Val Val 
                245                 250                 255     


His Gly Leu Val Asp Phe Ile Gln Asn Tyr Ser Arg Lys Gly His Glu 
            260                 265                 270         


Thr Pro Gln Pro Gln Pro Asn Ser Lys Tyr Lys Thr Ser Met Cys Arg 
        275                 280                 285             


Asp Leu Arg Gln Gln Gly Gly Cys Pro Arg Gly Thr Asn Cys Thr Phe 
    290                 295                 300                 


Ala His Ser Gln Glu Glu Leu Glu Lys Tyr Arg Leu Arg Asn Lys Lys 
305                 310                 315                 320 


Ile Asn Ala Thr Val Arg Thr Phe Pro Leu Leu Asn Lys Val Gly Val 
                325                 330                 335     


Asn Asn Thr Val Thr Thr Thr Ala Gly Asn Val Ile Ser Val Ile Gly 
            340                 345                 350         


Ser Thr Glu Thr Thr Gly Lys Ile Val Pro Ser Thr Asn Gly Ile Ser 
        355                 360                 365             


Asn Ala Glu Asn Ser Val Ser Gln Leu Ile Ser Arg Ser Thr Asp Ser 
    370                 375                 380                 


Thr Leu Arg Ala Leu Glu Thr Val Lys Lys Val Gly Lys Val Gly Ala 
385                 390                 395                 400 


Asn Gly Gln Asn Ala Ala Gly Pro Ser Ala Asp Ser Val Thr Glu Asn 
                405                 410                 415     


Lys Ile Gly Ser Pro Pro Lys Thr Pro Val Ser Asn Val Ala Ala Thr 
            420                 425                 430         


Ser Ala Gly Pro Ser Asn Val Gly Thr Glu Leu Asn Ser Val Pro Gln 
        435                 440                 445             


Lys Ser Ser Pro Phe Leu Thr Arg Val Pro Val Tyr Pro Pro His Ser 
    450                 455                 460                 


Glu Asn Ile Gln Tyr Phe Gln Asp Pro Arg Thr Gln Ile Pro Phe Glu 
465                 470                 475                 480 


Val Pro Gln Tyr Pro Gln Thr Gly Tyr Tyr Pro Pro Pro Pro Thr Val 
                485                 490                 495     


Pro Ala Gly Val Ala Pro Cys Val Pro Arg Phe Val Arg Ser Asn Asn 
            500                 505                 510         


Val Pro Glu Ser Ser Leu Pro Pro Ala Ser Met Pro Tyr Ala Asp His 
        515                 520                 525             


Tyr Ser Thr Phe Ser Pro Arg Asp Arg Met Asn Ser Ser Pro Tyr Gln 
    530                 535                 540                 


Pro Pro Pro Pro Gln Pro Tyr Gly Pro Val Pro Pro Val Pro Ser Gly 
545                 550                 555                 560 


Met Tyr Ala Pro Val Tyr Asp Ser Arg Arg Ile Trp Arg Pro Pro Met 
                565                 570                 575     


Tyr Gln Arg Asp Asp Ile Ile Arg Ser Asn Ser Leu Pro Pro Met Asp 
            580                 585                 590         


Val Met His Ser Ser Val Tyr Gln Thr Ser Leu Arg Glu Arg Tyr Asn 
        595                 600                 605             


Ser Leu Asp Gly Tyr Tyr Ser Val Ala Cys Gln Pro Pro Ser Glu Pro 
    610                 615                 620                 


Arg Thr Thr Val Pro Leu Pro Arg Glu Pro Cys Gly His Leu Lys Thr 
625                 630                 635                 640 


Ser Cys Glu Glu Gln Ile Arg Arg Lys Pro Asp Gln Trp Ala Gln Tyr 
                645                 650                 655     


His Thr Gln Lys Ala Pro Leu Val Ser Ser Thr Leu Pro Val Ala Thr 
            660                 665                 670         


Gln Ser Pro Thr Pro Pro Ser Pro Leu Phe Ser Val Asp Phe Arg Ala 
        675                 680                 685             


Asp Phe Ser Glu Ser Val Ser Gly Thr Lys Phe Glu Glu Asp His Leu 
    690                 695                 700                 


Ser His Tyr Ser Pro Trp Ser Cys Gly Thr Ile Gly Ser Cys Ile Asn 
705                 710                 715                 720 


Ala Ile Asp Ser Glu Pro Lys Asp Val Ile Ala Asn Ser Asn Ala Val 
                725                 730                 735     


Leu Met Asp Leu Asp Ser Gly Asp Val Lys Arg Arg Val His Leu Phe 
            740                 745                 750         


Glu Thr Gln Arg Arg Thr Lys Glu Glu Asp Pro Ile Ile Pro Phe Ser 
        755                 760                 765             


Asp Gly Pro Ile Ile Ser Lys Trp Gly Ala Ile Ser Arg Ser Ser Arg 
    770                 775                 780                 


Thr Gly Tyr His Thr Thr Asp Pro Val Gln Ala Thr Ala Ser Gln Gly 
785                 790                 795                 800 


Ser Ala Thr Lys Pro Ile Ser Val Ser Asp Tyr Val Pro Tyr Val Asn 
                805                 810                 815     


Ala Val Asp Ser Arg Trp Ser Ser Tyr Gly Asn Glu Ala Thr Ser Ser 
            820                 825                 830         


Ala His Tyr Val Glu Arg Asp Arg Phe Ile Val Thr Asp Leu Ser Gly 
        835                 840                 845             


His Arg Lys His Ser Ser Thr Gly Asp Leu Leu Ser Leu Glu Leu Gln 
    850                 855                 860                 


Gln Ala Lys Ser Asn Ser Leu Leu Leu Gln Arg Glu Ala Asn Ala Leu 
865                 870                 875                 880 


Ala Met Gln Gln Lys Trp Asn Ser Leu Asp Glu Gly Arg His Leu Thr 
                885                 890                 895     


Leu Asn Leu Leu Ser Lys Glu Ile Glu Leu Arg Asn Gly Glu Val Lys 
            900                 905                 910         


Lys Leu Asn Leu Ser Ala Ser Cys Leu Met Tyr Leu Phe Ser Ala Ala 
        915                 920                 925             


Ala Ser Trp Leu Tyr His Tyr 
    930                 935 


<210> 6370
<211> 478
<212> PRT
<213> Homo sapiens

<400> 6370
Met Pro Val Gln Ala Ala Gln Trp Thr Glu Phe Leu Ser Cys Pro Ile 
1               5                   10                  15      


Cys Tyr Asn Glu Phe Asp Glu Asn Val His Lys Pro Ile Ser Leu Gly 
            20                  25                  30          


Cys Ser His Thr Val Cys Lys Thr Cys Leu Asn Lys Leu His Arg Lys 
        35                  40                  45              


Ala Cys Pro Phe Asp Gln Thr Ala Ile Asn Thr Asp Ile Asp Val Leu 
    50                  55                  60                  


Pro Val Asn Phe Ala Leu Leu Gln Leu Val Gly Ala Gln Val Pro Asp 
65                  70                  75                  80  


His Gln Ser Ile Lys Leu Ser Asn Leu Gly Glu Asn Lys His Tyr Glu 
                85                  90                  95      


Val Ala Lys Lys Cys Val Glu Asp Leu Ala Leu Tyr Leu Lys Pro Leu 
            100                 105                 110         


Ser Gly Gly Lys Gly Val Ala Ser Leu Asn Gln Ser Ala Leu Ser Arg 
        115                 120                 125             


Pro Met Gln Arg Lys Leu Val Thr Leu Val Asn Cys Gln Leu Val Glu 
    130                 135                 140                 


Glu Glu Gly Arg Val Arg Ala Met Arg Ala Ala Arg Ser Leu Gly Glu 
145                 150                 155                 160 


Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro Gln Gln Leu 
                165                 170                 175     


Ser Ala Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys Gln Phe Leu 
            180                 185                 190         


Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu Leu Ala Leu 
        195                 200                 205             


Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu Phe Val Val 
    210                 215                 220                 


Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr Ser Ile Gly 
225                 230                 235                 240 


His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys Val Thr Lys 
                245                 250                 255     


Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu Phe Arg Ser 
            260                 265                 270         


Tyr Glu Ala Leu Arg Arg Glu His Asp Ala Gln Ile Val His Ile Ala 
        275                 280                 285             


Met Glu Ala Gly Leu Arg Ile Ser Pro Glu Gln Trp Ser Ser Leu Leu 
    290                 295                 300                 


Tyr Gly Asp Leu Ala His Lys Ser His Met Gln Ser Ile Ile Asp Lys 
305                 310                 315                 320 


Leu Gln Ser Pro Glu Ser Phe Ala Lys Ser Val Gln Glu Leu Thr Ile 
                325                 330                 335     


Val Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg Leu Arg Pro 
            340                 345                 350         


His Leu Glu Leu Leu Ala Asn Ile Asp Pro Asn Pro Asp Ala Val Ser 
        355                 360                 365             


Pro Thr Trp Glu Gln Leu Glu Asn Ala Met Val Ala Val Lys Thr Val 
    370                 375                 380                 


Val His Gly Leu Val Asp Phe Ile Gln Asn Tyr Ser Arg Lys Gly His 
385                 390                 395                 400 


Glu Thr Pro Gln Pro Gln Pro Asn Ser Lys Tyr Lys Thr Ser Met Cys 
                405                 410                 415     


Arg Asp Leu Arg Gln Gln Gly Gly Cys Pro Arg Gly Thr Asn Cys Thr 
            420                 425                 430         


Phe Ala His Ser Gln Glu Glu Leu Glu Lys Tyr Arg Leu Arg Asn Lys 
        435                 440                 445             


Lys Ile Asn Ala Thr Glu Val Leu Lys Gln Gln Gly Lys Leu Phe Gln 
    450                 455                 460                 


Val Gln Thr Glu Phe Gln Met Gln Lys Thr Val Phe Pro Ser 
465                 470                 475             


<210> 6371
<211> 1191
<212> PRT
<213> Homo sapiens

<400> 6371
Met Pro Val Gln Ala Ala Gln Trp Thr Glu Phe Leu Ser Cys Pro Ile 
1               5                   10                  15      


Cys Tyr Asn Glu Phe Asp Glu Asn Val His Lys Pro Ile Ser Leu Gly 
            20                  25                  30          


Cys Ser His Thr Val Cys Lys Thr Cys Leu Asn Lys Leu His Arg Lys 
        35                  40                  45              


Ala Cys Pro Phe Asp Gln Thr Ala Ile Asn Thr Asp Ile Asp Val Leu 
    50                  55                  60                  


Pro Val Asn Phe Ala Leu Leu Gln Leu Val Gly Ala Gln Val Pro Asp 
65                  70                  75                  80  


His Gln Ser Ile Lys Leu Ser Asn Leu Gly Glu Asn Lys His Tyr Glu 
                85                  90                  95      


Val Ala Lys Lys Cys Val Glu Asp Leu Ala Leu Tyr Leu Lys Pro Leu 
            100                 105                 110         


Ser Gly Gly Lys Gly Val Ala Ser Leu Asn Gln Ser Ala Leu Ser Arg 
        115                 120                 125             


Pro Met Gln Arg Lys Leu Val Thr Leu Val Asn Cys Gln Leu Val Glu 
    130                 135                 140                 


Glu Glu Gly Arg Val Arg Ala Met Arg Ala Ala Arg Ser Leu Gly Glu 
145                 150                 155                 160 


Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro Gln Gln Leu 
                165                 170                 175     


Ser Ala Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys Gln Phe Leu 
            180                 185                 190         


Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu Leu Ala Leu 
        195                 200                 205             


Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu Phe Val Val 
    210                 215                 220                 


Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr Ser Ile Gly 
225                 230                 235                 240 


His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys Val Thr Lys 
                245                 250                 255     


Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu Phe Arg Ser 
            260                 265                 270         


Tyr Glu Ala Leu Arg Arg Glu His Asp Ala Gln Ile Val His Ile Ala 
        275                 280                 285             


Met Glu Ala Gly Leu Arg Ile Ser Pro Glu Gln Trp Ser Ser Leu Leu 
    290                 295                 300                 


Tyr Gly Asp Leu Ala His Lys Ser His Met Gln Ser Ile Ile Asp Lys 
305                 310                 315                 320 


Leu Gln Ser Pro Glu Ser Phe Ala Lys Ser Val Gln Glu Leu Thr Ile 
                325                 330                 335     


Val Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg Leu Arg Pro 
            340                 345                 350         


His Leu Glu Leu Leu Ala Asn Ile Asp Pro Asn Pro Asp Ala Val Ser 
        355                 360                 365             


Pro Thr Trp Glu Gln Leu Glu Asn Ala Met Val Ala Val Lys Thr Val 
    370                 375                 380                 


Val His Gly Leu Val Asp Phe Ile Gln Asn Tyr Ser Arg Lys Gly His 
385                 390                 395                 400 


Glu Thr Pro Gln Pro Gln Pro Asn Ser Lys Tyr Lys Thr Ser Met Cys 
                405                 410                 415     


Arg Asp Leu Arg Gln Gln Gly Gly Cys Pro Arg Gly Thr Asn Cys Thr 
            420                 425                 430         


Phe Ala His Ser Gln Glu Glu Leu Glu Lys Tyr Arg Leu Arg Asn Lys 
        435                 440                 445             


Lys Ile Asn Ala Thr Val Arg Thr Phe Pro Leu Leu Asn Lys Val Gly 
    450                 455                 460                 


Val Asn Asn Thr Val Thr Thr Thr Ala Gly Asn Val Ile Ser Val Ile 
465                 470                 475                 480 


Gly Ser Thr Glu Thr Thr Gly Lys Ile Val Pro Ser Thr Asn Gly Ile 
                485                 490                 495     


Ser Asn Ala Glu Asn Ser Val Ser Gln Leu Ile Ser Arg Ser Thr Asp 
            500                 505                 510         


Ser Thr Leu Arg Ala Leu Glu Thr Val Lys Lys Val Gly Lys Val Gly 
        515                 520                 525             


Ala Asn Gly Gln Asn Ala Ala Gly Pro Ser Ala Asp Ser Val Thr Glu 
    530                 535                 540                 


Asn Lys Ile Gly Ser Pro Pro Lys Thr Pro Val Ser Asn Val Ala Ala 
545                 550                 555                 560 


Thr Ser Ala Gly Pro Ser Asn Val Gly Thr Glu Leu Asn Ser Val Pro 
                565                 570                 575     


Gln Lys Ser Ser Pro Phe Leu Thr Arg Val Pro Val Tyr Pro Pro His 
            580                 585                 590         


Ser Glu Asn Ile Gln Tyr Phe Gln Asp Pro Arg Thr Gln Ile Pro Phe 
        595                 600                 605             


Glu Val Pro Gln Tyr Pro Gln Thr Gly Tyr Tyr Pro Pro Pro Pro Thr 
    610                 615                 620                 


Val Pro Ala Gly Val Ala Pro Cys Val Pro Arg Phe Val Arg Ser Asn 
625                 630                 635                 640 


Asn Val Pro Glu Ser Ser Leu Pro Pro Ala Ser Met Pro Tyr Ala Asp 
                645                 650                 655     


His Tyr Ser Thr Phe Ser Pro Arg Asp Arg Met Asn Ser Ser Pro Tyr 
            660                 665                 670         


Gln Pro Pro Pro Pro Gln Pro Tyr Gly Pro Val Pro Pro Val Pro Ser 
        675                 680                 685             


Gly Met Tyr Ala Pro Val Tyr Asp Ser Arg Arg Ile Trp Arg Pro Pro 
    690                 695                 700                 


Met Tyr Gln Arg Asp Asp Ile Ile Arg Ser Asn Ser Leu Pro Pro Met 
705                 710                 715                 720 


Asp Val Met His Ser Ser Val Tyr Gln Thr Ser Leu Arg Glu Arg Tyr 
                725                 730                 735     


Asn Ser Leu Asp Gly Tyr Tyr Ser Val Ala Cys Gln Pro Pro Ser Glu 
            740                 745                 750         


Pro Arg Thr Thr Val Pro Leu Pro Arg Glu Pro Cys Gly His Leu Lys 
        755                 760                 765             


Thr Ser Cys Glu Glu Gln Ile Arg Arg Lys Pro Asp Gln Trp Ala Gln 
    770                 775                 780                 


Tyr His Thr Gln Lys Ala Pro Leu Val Ser Ser Thr Leu Pro Val Ala 
785                 790                 795                 800 


Thr Gln Ser Pro Thr Pro Pro Ser Pro Leu Phe Ser Val Asp Phe Arg 
                805                 810                 815     


Ala Asp Phe Ser Glu Ser Val Ser Gly Thr Lys Phe Glu Glu Asp His 
            820                 825                 830         


Leu Ser His Tyr Ser Pro Trp Ser Cys Gly Thr Ile Gly Ser Cys Ile 
        835                 840                 845             


Asn Ala Ile Asp Ser Glu Pro Lys Asp Val Ile Ala Asn Ser Asn Ala 
    850                 855                 860                 


Val Leu Met Asp Leu Asp Ser Gly Asp Val Lys Arg Arg Val His Leu 
865                 870                 875                 880 


Phe Glu Thr Gln Arg Arg Thr Lys Glu Glu Asp Pro Ile Ile Pro Phe 
                885                 890                 895     


Ser Asp Gly Pro Ile Ile Ser Lys Trp Gly Ala Ile Ser Arg Ser Ser 
            900                 905                 910         


Arg Thr Gly Tyr His Thr Thr Asp Pro Val Gln Ala Thr Ala Ser Gln 
        915                 920                 925             


Gly Ser Ala Thr Lys Pro Ile Ser Val Ser Asp Tyr Val Pro Tyr Val 
    930                 935                 940                 


Asn Ala Val Asp Ser Arg Trp Ser Ser Tyr Gly Asn Glu Ala Thr Ser 
945                 950                 955                 960 


Ser Ala His Tyr Val Glu Arg Asp Arg Phe Ile Val Thr Asp Leu Ser 
                965                 970                 975     


Gly His Arg Lys His Ser Ser Thr Gly Asp Leu Leu Ser Leu Glu Leu 
            980                 985                 990         


Gln Gln Ala Lys Ser Asn Ser Leu  Leu Leu Gln Arg Glu  Ala Asn Ala 
        995                 1000                 1005             


Leu Ala  Met Gln Gln Lys Trp  Asn Ser Leu Asp Glu  Gly Arg His 
    1010                 1015                 1020             


Leu Thr  Leu Asn Leu Leu Ser  Lys Glu Ile Glu Leu  Arg Asn Gly 
    1025                 1030                 1035             


Glu Leu  Gln Ser Asp Tyr Thr  Glu Asp Ala Thr Asp  Thr Lys Pro 
    1040                 1045                 1050             


Asp Arg  Asp Ile Glu Leu Glu  Leu Ser Ala Leu Asp  Thr Asp Glu 
    1055                 1060                 1065             


Pro Asp  Gly Gln Ser Glu Pro  Ile Glu Glu Ile Leu  Asp Ile Gln 
    1070                 1075                 1080             


Leu Gly  Ile Ser Ser Gln Asn  Asp Gln Leu Leu Asn  Gly Met Ala 
    1085                 1090                 1095             


Val Glu  Asn Gly His Pro Val  Gln Gln His Gln Lys  Glu Pro Pro 
    1100                 1105                 1110             


Lys Gln  Lys Lys Gln Ser Leu  Gly Glu Asp His Val  Ile Leu Glu 
    1115                 1120                 1125             


Glu Gln  Lys Thr Ile Leu Pro  Val Thr Ser Cys Phe  Ser Gln Pro 
    1130                 1135                 1140             


Leu Pro  Val Ser Ile Ser Asn  Ala Ser Cys Leu Pro  Ile Thr Thr 
    1145                 1150                 1155             


Ser Val  Ser Ala Gly Asn Leu  Ile Leu Lys Thr His  Val Met Ser 
    1160                 1165                 1170             


Glu Asp  Lys Asn Asp Phe Leu  Lys Pro Val Ala Asn  Gly Lys Met 
    1175                 1180                 1185             


Val Asn  Ser 
    1190     


<210> 6372
<211> 522
<212> PRT
<213> Homo sapiens

<400> 6372
Met Ala Ala Ser Ala Lys Arg Lys Gln Glu Glu Lys His Leu Lys Met 
1               5                   10                  15      


Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp Cys 
            20                  25                  30          


Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe Val 
        35                  40                  45              


Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His Arg 
    50                  55                  60                  


Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu Phe 
65                  70                  75                  80  


Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly Leu 
                85                  90                  95      


Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln Lys 
            100                 105                 110         


Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr Val 
        115                 120                 125             


Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile Ser 
    130                 135                 140                 


Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro Leu 
145                 150                 155                 160 


Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys Gly 
                165                 170                 175     


Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln Gln 
            180                 185                 190         


Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile Phe 
        195                 200                 205             


Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn Phe 
    210                 215                 220                 


Ala His Phe Asn Ser His Ala Gly Gly Ser Ala Ala Ser Val Asn Ala 
225                 230                 235                 240 


Asn Phe Ala His Phe Asp Asn Phe Pro Lys Ser Ser Ser Ala Asp Phe 
                245                 250                 255     


Gly Thr Phe Asn Thr Ser Gln Ser His Gln Thr Ala Ser Ala Val Ser 
            260                 265                 270         


Lys Val Ser Thr Asn Lys Ala Gly Leu Gln Thr Ala Asp Lys Tyr Ala 
        275                 280                 285             


Ala Leu Ala Asn Leu Asp Asn Ile Phe Ser Ala Gly Gln Gly Gly Asp 
    290                 295                 300                 


Gln Gly Ser Gly Phe Gly Thr Thr Gly Lys Ala Pro Val Gly Ser Val 
305                 310                 315                 320 


Val Ser Val Pro Ser Gln Ser Ser Ala Ser Ser Asp Lys Tyr Ala Ala 
                325                 330                 335     


Leu Ala Glu Leu Asp Ser Val Phe Ser Ser Ala Ala Thr Ser Ser Asn 
            340                 345                 350         


Ala Tyr Thr Ser Thr Ser Asn Ala Ser Ser Asn Val Phe Gly Thr Val 
        355                 360                 365             


Pro Val Val Ala Ser Ala Gln Thr Gln Pro Ala Ser Ser Ser Val Pro 
    370                 375                 380                 


Ala Pro Phe Gly Ala Thr Pro Ser Thr Asn Pro Phe Val Ala Ala Ala 
385                 390                 395                 400 


Gly Pro Ser Val Ala Ser Ser Thr Asn Pro Phe Gln Thr Asn Ala Arg 
                405                 410                 415     


Gly Ala Thr Ala Ala Thr Phe Gly Thr Ala Ser Met Ser Met Pro Thr 
            420                 425                 430         


Gly Phe Gly Thr Pro Ala Pro Tyr Ser Leu Pro Thr Ser Phe Ser Gly 
        435                 440                 445             


Ser Phe Gln Gln Pro Ala Phe Pro Ala Gln Ala Ala Phe Pro Gln Gln 
    450                 455                 460                 


Thr Ala Phe Ser Gln Gln Pro Asn Gly Ala Gly Phe Ala Ala Phe Gly 
465                 470                 475                 480 


Gln Thr Lys Pro Val Val Thr Pro Phe Gly Gln Val Ala Ala Ala Gly 
                485                 490                 495     


Val Ser Ser Asn Pro Phe Met Thr Gly Ala Pro Thr Gly Gln Phe Pro 
            500                 505                 510         


Thr Gly Ser Ser Ser Thr Asn Pro Phe Leu 
        515                 520         


<210> 6373
<211> 507
<212> PRT
<213> Homo sapiens

<400> 6373
Met Gln Asp Asp Ser Ile Glu Ala Ser Thr Ser Ile Ser Gln Leu Leu 
1               5                   10                  15      


Arg Glu Ser Tyr Leu Ala Glu Thr Arg His Arg Gly Asn Asn Glu Arg 
            20                  25                  30          


Ser Arg Ala Glu Pro Ser Ser Asn Pro Cys His Phe Gly Ser Pro Ser 
        35                  40                  45              


Gly Ala Ala Glu Gly Gly Gly Gly Gln Asp Asp Leu Pro Asp Leu Ser 
    50                  55                  60                  


Ala Phe Leu Ser Gln Glu Glu Leu Asp Glu Ser Val Asn Leu Ala Arg 
65                  70                  75                  80  


Leu Ala Ile Asn Tyr Asp Pro Leu Glu Lys Ala Asp Glu Thr Gln Ala 
                85                  90                  95      


Arg Lys Arg Leu Ser Pro Asp Gln Met Lys His Ser Pro Asn Leu Ser 
            100                 105                 110         


Phe Glu Pro Asn Phe Cys Gln Asp Asn Pro Arg Ser Pro Thr Ser Ser 
        115                 120                 125             


Lys Glu Ser Pro Gln Glu Ala Lys Arg Pro Gln Tyr Cys Ser Glu Thr 
    130                 135                 140                 


Gln Ser Lys Lys Val Phe Leu Asn Lys Ala Ala Asp Phe Ile Glu Glu 
145                 150                 155                 160 


Leu Ser Ser Leu Phe Lys Ser His Ser Ser Lys Arg Ile Arg Pro Arg 
                165                 170                 175     


Ala Cys Lys Asn His Lys Ser Lys Leu Glu Ser Gln Asn Lys Val Met 
            180                 185                 190         


Gln Glu Asn Ser Ser Ser Phe Ser Asp Leu Ser Glu Arg Arg Glu Arg 
        195                 200                 205             


Ser Ser Val Pro Ile Pro Ile Pro Ala Asp Thr Arg Asp Asn Glu Val 
    210                 215                 220                 


Asn His Ala Leu Glu Gln Gln Glu Ala Lys Arg Arg Glu Ala Glu Gln 
225                 230                 235                 240 


Ala Ala Ser Glu Ala Ala Gly Gly Asp Thr Thr Pro Gly Ser Ser Pro 
                245                 250                 255     


Ser Ser Leu Tyr Tyr Glu Glu Pro Leu Gly Gln Pro Pro Arg Phe Thr 
            260                 265                 270         


Gln Lys Leu Arg Ser Arg Glu Val Pro Glu Gly Thr Arg Val Gln Leu 
        275                 280                 285             


Asp Cys Ile Val Val Gly Ile Pro Pro Pro Gln Val Arg Trp Tyr Cys 
    290                 295                 300                 


Glu Gly Lys Glu Leu Glu Asn Ser Pro Asp Ile His Ile Val Gln Ala 
305                 310                 315                 320 


Gly Asn Leu His Ser Leu Thr Ile Ala Glu Ala Phe Glu Glu Asp Thr 
                325                 330                 335     


Gly Arg Tyr Ser Cys Phe Ala Ser Asn Ile Tyr Gly Thr Asp Ser Thr 
            340                 345                 350         


Ser Ala Glu Ile Tyr Ile Glu Gly Val Ser Ser Ser Asp Ser Glu Gly 
        355                 360                 365             


Asp Pro Asn Lys Glu Glu Met Asn Arg Ile Gln Lys Pro Asn Glu Val 
    370                 375                 380                 


Ser Ser Pro Pro Thr Thr Ser Ala Val Ile Pro Pro Ala Val Pro Gln 
385                 390                 395                 400 


Ala Gln His Leu Val Ala Gln Pro Arg Val Ala Thr Ile Gln Gln Cys 
                405                 410                 415     


Gln Ser Pro Thr Asn Tyr Leu Gln Gly Leu Asp Gly Lys Pro Ile Ile 
            420                 425                 430         


Ala Ala Pro Val Phe Thr Lys Met Leu Gln Asn Leu Ser Ala Ser Glu 
        435                 440                 445             


Gly Gln Leu Val Val Phe Glu Cys Arg Val Lys Gly Ala Pro Ser Pro 
    450                 455                 460                 


Lys Val Glu Trp Tyr Arg Glu Gly Thr Leu Ile Glu Asp Ser Pro Asp 
465                 470                 475                 480 


Phe Arg Ile Leu Gln Lys Lys Pro Arg Ser Met Ala Glu Pro Gly Lys 
                485                 490                 495     


Asp Asp Phe Asn Phe Asn Leu Leu Val Tyr Glu 
            500                 505         


<210> 6374
<211> 1049
<212> PRT
<213> Homo sapiens

<400> 6374
Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 
65                  70                  75                  80  


Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 
                85                  90                  95      


Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 
        115                 120                 125             


Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 
    130                 135                 140                 


Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 
145                 150                 155                 160 


Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 
                165                 170                 175     


Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 
            180                 185                 190         


Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 
        195                 200                 205             


Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 
    210                 215                 220                 


Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 
225                 230                 235                 240 


Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 
                245                 250                 255     


Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 
            260                 265                 270         


Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 
        275                 280                 285             


Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 
305                 310                 315                 320 


Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 
                325                 330                 335     


Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 
            340                 345                 350         


Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 
    370                 375                 380                 


Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 
385                 390                 395                 400 


Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 
                405                 410                 415     


Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 
            420                 425                 430         


Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 
        435                 440                 445             


Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 
    450                 455                 460                 


Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 
465                 470                 475                 480 


Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 
                485                 490                 495     


Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 
            500                 505                 510         


Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 
        515                 520                 525             


Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 
    530                 535                 540                 


Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 
545                 550                 555                 560 


Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 
                565                 570                 575     


Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 
            580                 585                 590         


Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 
        595                 600                 605             


Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 
    610                 615                 620                 


Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 
625                 630                 635                 640 


Gly Met Leu Ala Asp Ile Pro Val Thr Ile Cys Thr Tyr Pro Phe Val 
                645                 650                 655     


Phe Asp Ala Gln Ala Lys Thr Thr Leu Leu Gln Thr Asp Ala Val Leu 
            660                 665                 670         


Gln Met Gln Met Ala Ile Asp Gln Ala His Arg Gln Asn Val Ser Ser 
        675                 680                 685             


Leu Phe Leu Pro Val Ile Glu Ser Val Asn Pro Cys Leu Ile Leu Val 
    690                 695                 700                 


Val Arg Arg Glu Asn Ile Val Gly Asp Ala Met Glu Val Leu Arg Lys 
705                 710                 715                 720 


Thr Lys Asn Ile Asp Tyr Lys Lys Pro Leu Lys Val Ile Phe Val Gly 
                725                 730                 735     


Glu Asp Ala Val Asp Ala Gly Gly Val Arg Lys Glu Phe Phe Leu Leu 
            740                 745                 750         


Ile Met Arg Glu Leu Leu Asp Pro Lys Tyr Gly Met Phe Arg Tyr Tyr 
        755                 760                 765             


Glu Asp Ser Arg Leu Ile Trp Phe Ser Asp Lys Thr Phe Glu Asp Ser 
    770                 775                 780                 


Asp Leu Phe His Leu Ile Gly Val Ile Cys Gly Leu Ala Ile Tyr Asn 
785                 790                 795                 800 


Cys Thr Ile Val Asp Leu His Phe Pro Leu Ala Leu Tyr Lys Lys Leu 
                805                 810                 815     


Leu Lys Lys Lys Pro Ser Leu Asp Asp Leu Lys Glu Leu Met Pro Asp 
            820                 825                 830         


Val Gly Arg Ser Met Gln Gln Leu Leu Asp Tyr Pro Glu Asp Asp Ile 
        835                 840                 845             


Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Thr Val Glu Asn Phe Gly 
    850                 855                 860                 


Ala Thr Glu Val Lys Glu Leu Val Leu Asn Gly Ala Asp Thr Ala Val 
865                 870                 875                 880 


Asn Lys Gln Asn Arg Gln Glu Phe Val Asp Ala Tyr Val Asp Tyr Ile 
                885                 890                 895     


Phe Asn Lys Ser Val Ala Ser Leu Phe Asp Ala Phe His Ala Gly Phe 
            900                 905                 910         


His Lys Val Cys Gly Gly Lys Val Leu Leu Leu Phe Gln Pro Asn Glu 
        915                 920                 925             


Leu Gln Ala Met Val Ile Gly Asn Thr Asn Tyr Asp Trp Lys Glu Leu 
    930                 935                 940                 


Glu Lys Asn Thr Glu Tyr Lys Gly Glu Tyr Trp Ala Glu His Pro Thr 
945                 950                 955                 960 


Ile Lys Ile Phe Trp Glu Val Phe His Glu Leu Pro Leu Glu Lys Lys 
                965                 970                 975     


Lys Gln Phe Leu Leu Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile Leu 
            980                 985                 990         


Gly Met Lys Ser Leu Lys Leu Val  Ile Gln Ser Thr Gly  Gly Gly Glu 
        995                 1000                 1005             


Glu Tyr  Leu Pro Val Ser His  Thr Cys Phe Asn Leu  Leu Asp Leu 
    1010                 1015                 1020             


Pro Lys  Tyr Thr Glu Lys Glu  Thr Leu Arg Ser Lys  Leu Ile Gln 
    1025                 1030                 1035             


Ala Ile  Asp His Asn Glu Gly  Phe Ser Leu Ile 
    1040                 1045                 


<210> 6375
<211> 241
<212> PRT
<213> Homo sapiens

<400> 6375
Met Asn Ser Gly Arg Pro Glu Thr Met Glu Asn Leu Pro Ala Leu Tyr 
1               5                   10                  15      


Thr Ile Phe Gln Gly Glu Val Ala Met Val Thr Asp Tyr Gly Ala Phe 
            20                  25                  30          


Ile Lys Ile Pro Gly Cys Arg Lys Gln Gly Leu Val His Arg Thr His 
        35                  40                  45              


Met Ser Ser Cys Arg Val Asp Lys Pro Ser Glu Ile Val Asp Val Gly 
    50                  55                  60                  


Asp Lys Val Trp Val Lys Leu Ile Gly Arg Glu Met Lys Asn Asp Arg 
65                  70                  75                  80  


Ile Lys Val Ser Leu Ser Met Lys Val Val Asn Gln Gly Thr Gly Lys 
                85                  90                  95      


Asp Leu Asp Pro Asn Asn Val Ile Ile Glu Gln Glu Glu Arg Arg Arg 
            100                 105                 110         


Arg Ser Phe Gln Asp Tyr Thr Gly Gln Lys Ile Thr Leu Glu Ala Val 
        115                 120                 125             


Leu Asn Thr Thr Cys Lys Lys Cys Gly Cys Lys Gly His Phe Ala Lys 
    130                 135                 140                 


Asp Cys Phe Met Gln Pro Gly Gly Thr Lys Tyr Ser Leu Ile Pro Asp 
145                 150                 155                 160 


Glu Glu Glu Glu Lys Glu Glu Ala Lys Ser Ala Glu Phe Glu Lys Pro 
                165                 170                 175     


Asp Pro Thr Arg Asn Pro Ser Arg Lys Arg Lys Lys Glu Lys Lys Lys 
            180                 185                 190         


Lys Lys His Arg Asp Arg Lys Ser Ser Asp Ser Asp Ser Ser Asp Ser 
        195                 200                 205             


Glu Ser Asp Thr Gly Lys Arg Ala Arg His Thr Ser Lys Asp Ser Lys 
    210                 215                 220                 


Ala Ala Lys Lys Lys Lys Lys Lys Lys Lys His Lys Lys Lys His Lys 
225                 230                 235                 240 


Glu 
    


<210> 6376
<211> 289
<212> PRT
<213> Homo sapiens

<400> 6376
Met Ile Ile Asn Trp Asn Gln Val Ser Val Leu Trp Lys Cys Leu Leu 
1               5                   10                  15      


Lys Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp Arg Arg Ala 
            20                  25                  30          


Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro Ile His Gln 
        35                  40                  45              


Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu Ala Glu Ser 
    50                  55                  60                  


Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe Ser Ile Gln 
65                  70                  75                  80  


Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser Leu Glu Ser 
                85                  90                  95      


Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys His Phe Ala 
            100                 105                 110         


Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe Glu Asp Ser 
        115                 120                 125             


Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val Ala Glu Met 
    130                 135                 140                 


Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr Trp Asp Gln 
145                 150                 155                 160 


Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu Ser Arg Gly 
                165                 170                 175     


Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro Met Thr Tyr 
            180                 185                 190         


Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro Asp Tyr Gln 
        195                 200                 205             


Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met Glu Leu Val 
    210                 215                 220                 


Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala Phe Met Asp 
225                 230                 235                 240 


Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu Gly Lys Arg 
                245                 250                 255     


Ser Met Gln Gln Leu Asp Pro Ser Pro Ala Arg Lys Leu Leu Lys Leu 
            260                 265                 270         


Gln Leu Gln Asn Pro Pro Ala Ile His Gly Ser Gly Ser Gly Ser Cys 
        275                 280                 285             


Gln 
    


<210> 6377
<211> 249
<212> PRT
<213> Homo sapiens

<400> 6377
Met Thr Ser Val Thr Arg Ser Glu Ile Ile Asp Glu Leu Ser Arg Ser 
1               5                   10                  15      


Ile Ser Val Asp Leu Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu 
            20                  25                  30          


Ser Ser Phe Gln Phe Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp 
        35                  40                  45              


Thr Lys Gly Phe Ser Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu 
    50                  55                  60                  


Ser Glu Glu Leu Lys His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr 
65                  70                  75                  80  


Leu Gln Lys Cys Phe Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser 
                85                  90                  95      


Leu Glu Ala Ser Val Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser 
            100                 105                 110         


Leu Glu Arg Gln Thr Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu 
        115                 120                 125             


Ala Lys Glu Ile Leu Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr Glu 
    130                 135                 140                 


Val Lys Val Glu Pro Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu Val 
145                 150                 155                 160 


Leu Asn Thr Lys Pro Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser Lys 
                165                 170                 175     


Val Phe Asp Cys Met Glu Leu Val Met Asp Glu Leu Gln Gly Ser Val 
            180                 185                 190         


Lys Gln Leu Gln Ala Phe Met Asp Glu Ser Thr Gln Cys Phe Gln Lys 
        195                 200                 205             


Val Ser Val Gln Leu Gly Lys Arg Ser Met Gln Gln Leu Asp Pro Ser 
    210                 215                 220                 


Pro Ala Arg Lys Leu Leu Lys Leu Gln Leu Gln Asn Pro Pro Ala Ile 
225                 230                 235                 240 


His Gly Ser Gly Ser Gly Ser Cys Gln 
                245                 


<210> 6378
<211> 284
<212> PRT
<213> Homo sapiens

<400> 6378
Met Thr Ser Val Thr Arg Ser Glu Ile Ile Asp Glu Gln Ser Ala Ser 
1               5                   10                  15      


Tyr Gln Asp Arg Arg Gln Ser Trp Arg Arg Ala Ser Met Lys Glu Thr 
            20                  25                  30          


Asn Arg Arg Lys Ser Leu His Pro Ile His Gln Gly Ile Thr Glu Leu 
        35                  40                  45              


Ser Arg Ser Ile Ser Val Asp Leu Ala Glu Ser Lys Arg Leu Gly Cys 
    50                  55                  60                  


Leu Leu Leu Ser Ser Phe Gln Phe Ser Ile Gln Lys Leu Glu Pro Phe 
65                  70                  75                  80  


Leu Arg Asp Thr Lys Gly Phe Ser Leu Glu Ser Phe Arg Ala Lys Ala 
                85                  90                  95      


Ser Ser Leu Ser Glu Glu Leu Lys His Phe Ala Asp Gly Leu Glu Thr 
            100                 105                 110         


Asp Gly Thr Leu Gln Lys Cys Phe Glu Asp Ser Asn Gly Lys Ala Ser 
        115                 120                 125             


Asp Phe Ser Leu Glu Ala Ser Val Ala Glu Met Lys Glu Tyr Ile Thr 
    130                 135                 140                 


Lys Phe Ser Leu Glu Arg Gln Thr Trp Asp Gln Leu Leu Leu His Tyr 
145                 150                 155                 160 


Gln Gln Glu Ala Lys Glu Ile Leu Ser Arg Gly Ser Thr Glu Ala Lys 
                165                 170                 175     


Ile Thr Glu Val Lys Val Glu Pro Met Thr Tyr Leu Gly Ser Ser Gln 
            180                 185                 190         


Asn Glu Val Leu Asn Thr Lys Pro Asp Tyr Gln Lys Ile Leu Gln Asn 
        195                 200                 205             


Gln Ser Lys Val Phe Asp Cys Met Glu Leu Val Met Asp Glu Leu Gln 
    210                 215                 220                 


Gly Ser Val Lys Gln Leu Gln Ala Phe Met Asp Glu Ser Thr Gln Cys 
225                 230                 235                 240 


Phe Gln Lys Val Ser Val Gln Leu Gly Lys Arg Ser Met Gln Gln Leu 
                245                 250                 255     


Asp Pro Ser Pro Ala Arg Lys Leu Leu Lys Leu Gln Leu Gln Asn Pro 
            260                 265                 270         


Pro Ala Ile His Gly Ser Gly Ser Gly Ser Cys Gln 
        275                 280                 


<210> 6379
<211> 356
<212> PRT
<213> Homo sapiens

<400> 6379
Met Thr Ser Val Thr Arg Ser Glu Ile Ile Asp Glu Lys Gly Pro Val 
1               5                   10                  15      


Met Ser Lys Thr His Asp His Gln Leu Glu Ser Ser Leu Ser Pro Val 
            20                  25                  30          


Glu Val Phe Ala Lys Thr Ser Ala Ser Leu Glu Met Asn Gln Gly Val 
        35                  40                  45              


Ser Glu Glu Arg Ile His Leu Gly Ser Ser Pro Lys Lys Gly Gly Asn 
    50                  55                  60                  


Cys Asp Leu Ser His Gln Glu Arg Leu Gln Ser Lys Ser Leu His Leu 
65                  70                  75                  80  


Ser Pro Gln Glu Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp 
                85                  90                  95      


Arg Arg Ala Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro 
            100                 105                 110         


Ile His Gln Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu 
        115                 120                 125             


Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe 
    130                 135                 140                 


Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser 
145                 150                 155                 160 


Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys 
                165                 170                 175     


His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe 
            180                 185                 190         


Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val 
        195                 200                 205             


Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr 
    210                 215                 220                 


Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu 
225                 230                 235                 240 


Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro 
                245                 250                 255     


Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro 
            260                 265                 270         


Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met 
        275                 280                 285             


Glu Leu Val Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala 
    290                 295                 300                 


Phe Met Asp Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu 
305                 310                 315                 320 


Gly Lys Arg Ser Met Gln Gln Leu Asp Pro Ser Pro Ala Arg Lys Leu 
                325                 330                 335     


Leu Lys Leu Gln Leu Gln Asn Pro Pro Ala Ile His Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Cys Gln 
        355     


<210> 6380
<211> 356
<212> PRT
<213> Homo sapiens

<400> 6380
Met Thr Ser Val Thr Arg Ser Glu Ile Ile Asp Glu Lys Gly Pro Val 
1               5                   10                  15      


Met Ser Lys Thr His Asp His Gln Leu Glu Ser Ser Leu Ser Pro Val 
            20                  25                  30          


Glu Val Phe Ala Lys Thr Ser Ala Ser Leu Glu Met Asn Gln Gly Val 
        35                  40                  45              


Ser Glu Glu Arg Ile His Leu Gly Ser Ser Pro Lys Lys Gly Gly Asn 
    50                  55                  60                  


Cys Asp Leu Ser His Gln Glu Arg Leu Gln Ser Lys Ser Leu His Leu 
65                  70                  75                  80  


Ser Pro Gln Glu Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp 
                85                  90                  95      


Arg Arg Ala Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro 
            100                 105                 110         


Ile His Gln Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu 
        115                 120                 125             


Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe 
    130                 135                 140                 


Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser 
145                 150                 155                 160 


Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys 
                165                 170                 175     


His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe 
            180                 185                 190         


Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val 
        195                 200                 205             


Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr 
    210                 215                 220                 


Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu 
225                 230                 235                 240 


Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro 
                245                 250                 255     


Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro 
            260                 265                 270         


Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met 
        275                 280                 285             


Glu Leu Val Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala 
    290                 295                 300                 


Phe Met Asp Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu 
305                 310                 315                 320 


Gly Lys Arg Ser Met Gln Gln Leu Asp Pro Ser Pro Ala Arg Lys Leu 
                325                 330                 335     


Leu Lys Leu Gln Leu Gln Asn Pro Pro Ala Ile His Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Cys Gln 
        355     


<210> 6381
<211> 538
<212> PRT
<213> Homo sapiens

<400> 6381
Met Ala Ala Ala Ala Ser Val Thr Gly Arg Val Thr Trp Ala Ala Ser 
1               5                   10                  15      


Pro Met Arg Ser Leu Gly Leu Gly Arg Arg Leu Ser Leu Pro Gly Pro 
            20                  25                  30          


Arg Leu Asp Ala Val Thr Ala Ala Val Asn Pro Ser Leu Ser Asp His 
        35                  40                  45              


Gly Asn Gly Leu Gly Arg Gly Thr Arg Gly Ser Gly Cys Ser Gly Gly 
    50                  55                  60                  


Ser Leu Val Ala Asp Trp Gly Gly Gly Ala Ala Ala Ala Ala Ala Val 
65                  70                  75                  80  


Ala Leu Ala Leu Ala Pro Ala Leu Ser Thr Met Arg Arg Gly Ser Ser 
                85                  90                  95      


Glu Ser Glu Leu Ala Ala Arg Trp Glu Ala Glu Ala Val Ala Ala Ala 
            100                 105                 110         


Lys Ala Ala Ala Lys Ala Glu Ala Glu Ala Thr Ala Glu Thr Val Ala 
        115                 120                 125             


Glu Gln Val Arg Val Asp Ala Gly Ala Ala Gly Glu Pro Glu Cys Lys 
    130                 135                 140                 


Ala Gly Glu Glu Gln Pro Lys Val Leu Ala Pro Ala Pro Ala Gln Pro 
145                 150                 155                 160 


Ser Ala Ala Glu Glu Gly Asn Thr Gln Val Leu Gln Arg Pro Pro Pro 
                165                 170                 175     


Thr Leu Pro Pro Ser Lys Pro Lys Pro Val Gln Gly Leu Cys Pro His 
            180                 185                 190         


Gly Lys Pro Arg Asp Lys Gly Arg Ser Cys Lys Arg Ser Ser Gly His 
        195                 200                 205             


Gly Ser Gly Glu Asn Gly Ser Gln Arg Pro Val Thr Val Asp Ser Ser 
    210                 215                 220                 


Lys Ala Arg Thr Ser Leu Asp Ala Leu Lys Ile Ser Ile Arg Gln Leu 
225                 230                 235                 240 


Lys Trp Lys Glu Phe Pro Phe Gly Arg Arg Leu Pro Cys Asp Ile Tyr 
                245                 250                 255     


Trp His Gly Val Ser Phe His Asp Asn Asp Ile Phe Ser Gly Gln Val 
            260                 265                 270         


Asn Lys Phe Pro Gly Met Thr Glu Met Val Arg Lys Ile Thr Leu Ser 
        275                 280                 285             


Arg Ala Val Arg Thr Met Gln Asn Leu Phe Pro Glu Glu Tyr Asn Phe 
    290                 295                 300                 


Tyr Pro Arg Ser Trp Ile Leu Pro Asp Glu Phe Gln Leu Phe Val Ala 
305                 310                 315                 320 


Gln Val Gln Met Val Lys Asp Asp Asp Pro Ser Trp Lys Pro Thr Phe 
                325                 330                 335     


Ile Val Lys Pro Asp Gly Gly Cys Gln Gly Asp Gly Ile Tyr Leu Ile 
            340                 345                 350         


Lys Asp Pro Ser Asp Ile Arg Leu Ala Gly Thr Leu Gln Ser Arg Pro 
        355                 360                 365             


Ala Val Val Gln Glu Tyr Ile Cys Lys Pro Leu Leu Ile Asp Lys Leu 
    370                 375                 380                 


Lys Phe Asp Ile Arg Leu Tyr Val Leu Leu Lys Ser Leu Asp Pro Leu 
385                 390                 395                 400 


Glu Ile Tyr Ile Ala Lys Asp Gly Leu Ser Arg Phe Cys Thr Glu Pro 
                405                 410                 415     


Tyr Gln Glu Pro Thr Pro Lys Asn Leu His Arg Ile Phe Met His Leu 
            420                 425                 430         


Thr Asn Tyr Ser Leu Asn Ile His Ser Gly Asn Phe Ile His Ser Asp 
        435                 440                 445             


Ser Ala Ser Thr Gly Ser Lys Arg Thr Phe Ser Ser Ile Leu Cys Arg 
    450                 455                 460                 


Leu Ser Ser Lys Gly Val Asp Ile Lys Lys Val Trp Ser Asp Ile Ile 
465                 470                 475                 480 


Ser Val Val Ile Lys Thr Val Ile Ala Leu Thr Pro Glu Leu Lys Val 
                485                 490                 495     


Phe Tyr Gln Ser Asp Ile Pro Thr Gly Arg Pro Gly Pro Thr Cys Phe 
            500                 505                 510         


Gln Val Thr Ile Ala Ser Ser Gln Pro Ala Phe Pro Ala Leu Thr Gly 
        515                 520                 525             


Leu Lys Arg Ala Leu Trp Leu Arg Val Gly 
    530                 535             


<210> 6382
<211> 451
<212> PRT
<213> Homo sapiens

<400> 6382
Met Thr Glu Met Val Arg Lys Ile Thr Leu Ser Arg Ala Val Arg Thr 
1               5                   10                  15      


Met Gln Asn Leu Phe Pro Glu Glu Tyr Ile Cys Lys Pro Leu Leu Ile 
            20                  25                  30          


Asp Lys Leu Lys Phe Asp Ile Arg Leu Tyr Val Leu Leu Lys Ser Leu 
        35                  40                  45              


Asp Pro Leu Glu Ile Tyr Ile Ala Lys Asp Gly Leu Ser Arg Phe Cys 
    50                  55                  60                  


Thr Glu Pro Tyr Gln Glu Pro Thr Pro Lys Asn Leu His Arg Ile Phe 
65                  70                  75                  80  


Met His Leu Thr Asn Tyr Ser Leu Asn Ile His Ser Gly Asn Phe Ile 
                85                  90                  95      


His Ser Asp Ser Ala Ser Thr Gly Ser Lys Arg Thr Phe Ser Ser Ile 
            100                 105                 110         


Leu Cys Arg Leu Ser Ser Lys Gly Val Asp Ile Lys Lys Val Trp Ser 
        115                 120                 125             


Asp Ile Ile Ser Val Val Ile Lys Thr Val Ile Ala Leu Thr Pro Glu 
    130                 135                 140                 


Leu Lys Val Phe Tyr Gln Ser Asp Ile Pro Thr Gly Arg Pro Gly Pro 
145                 150                 155                 160 


Thr Cys Phe Gln Ile Leu Gly Phe Asp Ile Leu Leu Met Lys Asn Leu 
                165                 170                 175     


Lys Pro Ile Leu Leu Glu Val Asn Ala Asn Pro Ser Met Arg Ile Glu 
            180                 185                 190         


His Glu His Glu Leu Ser Pro Gly Val Phe Glu Asn Val Pro Ser Leu 
        195                 200                 205             


Val Asp Glu Glu Val Lys Val Ala Val Ile Arg Asp Thr Leu Arg Leu 
    210                 215                 220                 


Met Asp Pro Leu Lys Lys Lys Arg Glu Asn Gln Ser Gln Gln Leu Glu 
225                 230                 235                 240 


Lys Pro Phe Ala Gly Lys Glu Asp Ala Leu Asp Gly Glu Leu Thr Ser 
                245                 250                 255     


Ala Pro Asp Cys Asn Ala Asn Pro Glu Ala His Leu Pro Ser Ile Cys 
            260                 265                 270         


Leu Lys Gln Val Phe Pro Lys Tyr Ala Lys Gln Phe Asn Tyr Leu Arg 
        275                 280                 285             


Leu Val Asp Arg Met Ala Asn Leu Phe Ile Arg Phe Leu Gly Ile Lys 
    290                 295                 300                 


Gly Thr Met Lys Leu Gly Pro Thr Gly Phe Arg Thr Phe Ile Arg Ser 
305                 310                 315                 320 


Cys Lys Leu Ser Ser Ser Ser Leu Ser Met Ala Ala Val Asp Ile Leu 
                325                 330                 335     


Tyr Ile Asp Ile Thr Arg Arg Trp Asn Ser Met Thr Leu Asp Gln Arg 
            340                 345                 350         


Asp Ser Gly Met Cys Leu Gln Ala Phe Val Glu Ala Phe Phe Phe Leu 
        355                 360                 365             


Ala Gln Arg Lys Phe Lys Met Leu Pro Leu His Glu Gln Val Ala Ser 
    370                 375                 380                 


Leu Ile Asp Leu Cys Glu Tyr His Leu Ser Leu Leu Asp Glu Lys Arg 
385                 390                 395                 400 


Leu Val Cys Gly Arg Gly Val Pro Ser Gly Gly Arg Pro Pro His Arg 
                405                 410                 415     


Gly Pro Pro Gln Glu Pro Ser Pro Ser Ala Gln Pro Ala Gly Asp Asn 
            420                 425                 430         


Pro Pro Pro Arg Thr Ser Cys Ala Asn Lys Leu Ser His Pro Arg His 
        435                 440                 445             


Thr Leu Ser 
    450     


<210> 6383
<211> 547
<212> PRT
<213> Homo sapiens

<400> 6383
Met Lys Val Val Lys Ser Ala Glu His Tyr Thr Glu Thr Ala Leu Asp 
1               5                   10                  15      


Glu Ile Arg Leu Leu Lys Ser Val Arg Asn Ser Asp Pro Asn Asp Pro 
            20                  25                  30          


Asn Arg Glu Met Val Val Gln Leu Leu Asp Asp Phe Lys Ile Ser Gly 
        35                  40                  45              


Val Asn Gly Thr His Ile Cys Met Val Phe Glu Val Leu Gly His His 
    50                  55                  60                  


Leu Leu Lys Trp Ile Ile Lys Ser Asn Tyr Gln Gly Leu Pro Leu Pro 
65                  70                  75                  80  


Cys Val Lys Lys Ile Ile Gln Gln Val Leu Gln Gly Leu Asp Tyr Leu 
                85                  90                  95      


His Thr Lys Cys Arg Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile 
            100                 105                 110         


Leu Leu Ser Val Asn Glu Gln Tyr Ile Arg Arg Leu Ala Ala Glu Ala 
        115                 120                 125             


Thr Glu Trp Gln Arg Ser Gly Ala Pro Pro Pro Ser Gly Ser Ala Val 
    130                 135                 140                 


Ser Thr Ala Pro Gln Pro Lys Pro Ala Asp Lys Met Ser Lys Asn Lys 
145                 150                 155                 160 


Lys Lys Lys Leu Lys Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu 
                165                 170                 175     


Lys Arg Met Gln Glu Ile Glu Glu Met Glu Lys Glu Ser Gly Pro Gly 
            180                 185                 190         


Gln Lys Arg Pro Asn Lys Gln Glu Glu Ser Glu Ser Pro Val Glu Arg 
        195                 200                 205             


Pro Leu Lys Glu Asn Pro Pro Asn Lys Met Thr Gln Glu Lys Leu Glu 
    210                 215                 220                 


Glu Ser Ser Thr Ile Gly Gln Asp Gln Thr Leu Met Glu Arg Asp Thr 
225                 230                 235                 240 


Glu Gly Gly Ala Ala Glu Ile Asn Cys Asn Gly Val Ile Glu Val Ile 
                245                 250                 255     


Asn Tyr Thr Gln Asn Ser Asn Asn Glu Thr Leu Arg His Lys Glu Asp 
            260                 265                 270         


Leu His Asn Ala Asn Asp Cys Asp Val Gln Asn Leu Asn Gln Glu Ser 
        275                 280                 285             


Ser Phe Leu Ser Ser Gln Asn Gly Asp Ser Ser Thr Ser Gln Glu Thr 
    290                 295                 300                 


Asp Ser Cys Thr Pro Ile Thr Ser Glu Val Ser Asp Thr Met Val Cys 
305                 310                 315                 320 


Gln Ser Ser Ser Thr Val Gly Gln Ser Phe Ser Glu Gln His Ile Ser 
                325                 330                 335     


Gln Leu Gln Glu Ser Ile Arg Ala Glu Ile Pro Cys Glu Asp Glu Gln 
            340                 345                 350         


Glu Gln Glu His Asn Gly Pro Leu Asp Asn Lys Gly Lys Ser Thr Ala 
        355                 360                 365             


Gly Asn Phe Leu Val Asn Pro Leu Glu Pro Lys Asn Ala Glu Lys Leu 
    370                 375                 380                 


Lys Val Lys Ile Ala Asp Leu Gly Asn Ala Cys Trp His Lys His Phe 
385                 390                 395                 400 


Thr Glu Asp Ile Gln Thr Arg Gln Tyr Arg Ser Leu Glu Val Leu Ile 
                405                 410                 415     


Gly Ser Gly Tyr Asn Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met 
            420                 425                 430         


Ala Phe Glu Leu Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly 
        435                 440                 445             


Glu Glu Tyr Thr Arg Asp Glu Asp His Ile Val His Ile Ile Glu Leu 
    450                 455                 460                 


Ile Gly Arg Ile Pro Arg Arg Phe Ser Leu Ser Gly Lys Tyr Ser Gln 
465                 470                 475                 480 


Asp Phe Phe Ser His Arg Gly Asp Leu Lys His Ile Thr Lys Leu Lys 
                485                 490                 495     


Pro Trp Gly Leu Phe Glu Val Leu Val Glu Lys Tyr Glu Trp Ser Gln 
            500                 505                 510         


Glu Glu Ala Ala Gly Phe Thr Asp Phe Leu Leu Pro Met Leu Glu Leu 
        515                 520                 525             


Ile Pro Glu Lys Arg Ala Thr Ala Ala Glu Cys Leu Arg His Pro Trp 
    530                 535                 540                 


Leu Asn Ser 
545         


<210> 6384
<211> 655
<212> PRT
<213> Homo sapiens

<400> 6384
Met Glu Arg Lys Val Leu Ala Leu Gln Ala Arg Lys Lys Arg Thr Lys 
1               5                   10                  15      


Ala Lys Lys Asp Lys Ala Gln Arg Lys Ser Glu Thr Gln His Arg Gly 
            20                  25                  30          


Ser Ala Pro His Ser Glu Ser Asp Leu Pro Glu Gln Glu Glu Glu Ile 
        35                  40                  45              


Leu Gly Ser Asp Asp Asp Glu Gln Glu Asp Pro Asn Asp Tyr Cys Lys 
    50                  55                  60                  


Gly Gly Tyr His Leu Val Lys Ile Gly Asp Leu Phe Asn Gly Arg Tyr 
65                  70                  75                  80  


His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu 
                85                  90                  95      


Ser Trp Asp Ile Gln Gly Lys Lys Phe Val Ala Met Lys Val Val Lys 
            100                 105                 110         


Ser Ala Glu His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Arg Leu Leu 
        115                 120                 125             


Lys Ser Val Arg Asn Ser Asp Pro Asn Asp Pro Asn Arg Glu Met Val 
    130                 135                 140                 


Val Gln Leu Leu Asp Asp Phe Lys Ile Ser Gly Val Asn Gly Thr His 
145                 150                 155                 160 


Ile Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp Ile 
                165                 170                 175     


Ile Lys Ser Asn Tyr Gln Gly Leu Pro Leu Pro Cys Val Lys Lys Ile 
            180                 185                 190         


Ile Gln Gln Val Leu Gln Gly Leu Asp Tyr Leu His Thr Lys Cys Arg 
        195                 200                 205             


Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Leu Ser Val Asn 
    210                 215                 220                 


Glu Gln Tyr Ile Arg Arg Leu Ala Ala Glu Ala Thr Glu Trp Gln Arg 
225                 230                 235                 240 


Ser Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro Gln 
                245                 250                 255     


Pro Lys Pro Ala Asp Lys Met Ser Lys Asn Lys Lys Lys Lys Leu Lys 
            260                 265                 270         


Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Met Gln Glu 
        275                 280                 285             


Ile Glu Glu Met Glu Lys Glu Ser Gly Pro Gly Gln Lys Arg Pro Asn 
    290                 295                 300                 


Lys Gln Glu Glu Ser Glu Ser Pro Val Glu Arg Pro Leu Lys Glu Asn 
305                 310                 315                 320 


Pro Pro Asn Lys Met Thr Gln Glu Lys Leu Glu Glu Ser Ser Thr Ile 
                325                 330                 335     


Gly Gln Asp Gln Thr Leu Met Glu Arg Asp Thr Glu Gly Gly Ala Ala 
            340                 345                 350         


Glu Ile Asn Cys Asn Gly Val Ile Glu Val Ile Asn Tyr Thr Gln Asn 
        355                 360                 365             


Ser Asn Asn Glu Thr Leu Arg His Lys Glu Asp Leu His Asn Ala Asn 
    370                 375                 380                 


Asp Cys Asp Val Gln Asn Leu Asn Gln Glu Ser Ser Phe Leu Ser Ser 
385                 390                 395                 400 


Gln Asn Gly Asp Ser Ser Thr Ser Gln Glu Thr Asp Ser Cys Thr Pro 
                405                 410                 415     


Ile Thr Ser Glu Val Ser Asp Thr Met Val Cys Gln Ser Ser Ser Thr 
            420                 425                 430         


Val Gly Gln Ser Phe Ser Glu Gln His Ile Ser Gln Leu Gln Glu Ser 
        435                 440                 445             


Ile Arg Ala Glu Ile Pro Cys Glu Asp Glu Gln Glu Gln Glu His Asn 
    450                 455                 460                 


Gly Pro Leu Asp Asn Lys Gly Lys Ser Thr Ala Gly Asn Phe Leu Val 
465                 470                 475                 480 


Asn Pro Leu Glu Pro Lys Asn Ala Glu Lys Leu Lys Val Lys Ile Ala 
                485                 490                 495     


Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr Glu Asp Ile 
            500                 505                 510         


Gln Thr Arg Gln Tyr Arg Ser Leu Glu Val Leu Ile Gly Ser Gly Tyr 
        515                 520                 525             


Asn Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu Leu 
    530                 535                 540                 


Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly Glu Glu Tyr Thr 
545                 550                 555                 560 


Arg Asp Glu Asp His Ile Ala Leu Ile Ile Glu Leu Leu Gly Lys Val 
                565                 570                 575     


Pro Arg Lys Leu Ile Val Ala Gly Lys Tyr Ser Lys Glu Phe Phe Thr 
            580                 585                 590         


Lys Lys Gly Asp Leu Lys His Ile Thr Lys Leu Lys Pro Trp Gly Leu 
        595                 600                 605             


Phe Glu Val Leu Val Glu Lys Tyr Glu Trp Ser Gln Glu Glu Ala Ala 
    610                 615                 620                 


Gly Phe Thr Asp Phe Leu Leu Pro Met Leu Glu Leu Ile Pro Glu Lys 
625                 630                 635                 640 


Arg Ala Thr Ala Ala Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
                645                 650                 655 


<210> 6385
<211> 287
<212> PRT
<213> Homo sapiens

<400> 6385
Met Ala Ala Ser Leu Trp Met Gly Asp Leu Glu Pro Tyr Met Asp Glu 
1               5                   10                  15      


Asn Phe Ile Ser Arg Ala Phe Ala Thr Met Gly Glu Thr Val Met Ser 
            20                  25                  30          


Val Lys Ile Ile Arg Asn Arg Leu Thr Gly Ile Pro Ala Gly Tyr Cys 
        35                  40                  45              


Phe Val Glu Phe Ala Asp Leu Ala Thr Ala Glu Lys Cys Leu His Lys 
    50                  55                  60                  


Ile Asn Gly Lys Pro Leu Pro Gly Ala Thr Pro Ala Lys Arg Phe Lys 
65                  70                  75                  80  


Leu Asn Tyr Ala Thr Tyr Gly Lys Gln Pro Asp Asn Ser Pro Glu Tyr 
                85                  90                  95      


Ser Leu Phe Val Gly Asp Leu Thr Pro Asp Val Asp Asp Gly Met Leu 
            100                 105                 110         


Tyr Glu Phe Phe Val Lys Val Tyr Pro Ser Cys Arg Gly Gly Lys Val 
        115                 120                 125             


Val Leu Asp Gln Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Lys Phe 
    130                 135                 140                 


Thr Asp Glu Leu Glu Gln Lys Arg Ala Leu Thr Glu Cys Gln Gly Ala 
145                 150                 155                 160 


Val Gly Leu Gly Ser Lys Pro Val Arg Leu Ser Val Ala Ile Pro Lys 
                165                 170                 175     


Ala Ser Arg Val Lys Pro Val Glu Tyr Ser Gln Met Tyr Ser Tyr Ser 
            180                 185                 190         


Tyr Asn Gln Tyr Tyr Gln Gln Tyr Gln Asn Tyr Tyr Ala Gln Trp Gly 
        195                 200                 205             


Tyr Asp Gln Asn Thr Gly Ser Tyr Ser Tyr Ser Tyr Pro Gln Tyr Gly 
    210                 215                 220                 


Tyr Thr Gln Ser Thr Met Gln Thr Tyr Glu Glu Val Gly Asp Asp Ala 
225                 230                 235                 240 


Leu Glu Asp Pro Met Pro Gln Leu Asp Val Thr Glu Ala Asn Lys Glu 
                245                 250                 255     


Phe Met Glu Gln Ser Glu Glu Leu Tyr Asp Ala Leu Met Asp Cys His 
            260                 265                 270         


Trp Gln Pro Leu Asp Thr Val Ser Ser Glu Ile Pro Ala Met Met 
        275                 280                 285         


<210> 6386
<211> 145
<212> PRT
<213> Homo sapiens

<400> 6386
Met Ala Glu Arg Asn Glu Asp His His Leu Gln Val Leu Lys Glu Ser 
1               5                   10                  15      


Glu Val Leu Leu Gln Ala Lys Arg Ala Glu Leu Glu Lys Leu Lys Ser 
            20                  25                  30          


Gln Val Thr Ser Gln Gln Gln Glu Met Ala Val Leu Asp Arg Gln Leu 
        35                  40                  45              


Gly His Lys Lys Glu Glu Leu His Leu Leu Gln Gly Ser Met Val Gln 
    50                  55                  60                  


Ala Lys Ala Asp Leu Gln Glu Ala Leu Arg Leu Gly Glu Thr Glu Val 
65                  70                  75                  80  


Thr Glu Lys Cys Asn His Ile Arg Glu Val Lys Ser Leu Leu Glu Glu 
                85                  90                  95      


Leu Ser Phe Gln Lys Gly Glu Leu Asn Val Gln Ile Ser Glu Arg Lys 
            100                 105                 110         


Thr Gln Leu Thr Leu Ile Lys Gln Glu Ile Glu Lys Glu Glu Glu Asn 
        115                 120                 125             


Leu Gln Val Val Leu Arg Gln Met Ser Lys His Lys Thr Ala Phe Leu 
    130                 135                 140                 


Gln 
145 


<210> 6387
<211> 1007
<212> PRT
<213> Homo sapiens

<400> 6387
Met Gln His Leu Lys Ser Lys Lys Arg Glu Glu Arg Trp Met Arg Ala 
1               5                   10                  15      


Ser Lys Arg Gln Ser Glu Lys Glu Met Glu Glu Leu His His Asn Ile 
            20                  25                  30          


Asp Asp Leu Leu Gln Glu Lys Lys Ser Leu Glu Cys Glu Val Glu Glu 
        35                  40                  45              


Leu His Arg Thr Val Gln Lys Arg Gln Gln Gln Lys Asp Phe Ile Asp 
    50                  55                  60                  


Gly Asn Val Glu Ser Leu Met Thr Glu Leu Glu Ile Glu Lys Ser Leu 
65                  70                  75                  80  


Lys His His Glu Asp Ile Val Asp Glu Ile Glu Cys Ile Glu Lys Thr 
                85                  90                  95      


Leu Leu Lys Arg Arg Ser Glu Leu Arg Glu Ala Asp Arg Leu Leu Ala 
            100                 105                 110         


Glu Ala Glu Ser Glu Leu Ser Cys Thr Lys Glu Lys Val Cys Leu Leu 
        115                 120                 125             


Val Val Trp Gly Val Ser Ser Val Trp Thr Lys Asn Ala Val Glu Lys 
    130                 135                 140                 


Phe Thr Asp Ala Lys Arg Ser Leu Leu Gln Thr Glu Ser Asp Ala Glu 
145                 150                 155                 160 


Glu Leu Glu Arg Arg Ala Gln Glu Thr Ala Val Asn Leu Val Lys Ala 
                165                 170                 175     


Asp Gln Gln Leu Arg Ser Leu Gln Ala Asp Ala Lys Asp Leu Glu Gln 
            180                 185                 190         


His Lys Ile Lys Gln Glu Glu Ile Leu Lys Glu Ile Asn Lys Ile Val 
        195                 200                 205             


Ala Ala Lys Asp Ser Asp Phe Gln Cys Leu Ser Lys Lys Lys Glu Lys 
    210                 215                 220                 


Leu Thr Glu Glu Leu Gln Lys Leu Gln Lys Asp Ile Glu Met Ala Glu 
225                 230                 235                 240 


Arg Asn Glu Asp His His Leu Gln Val Leu Lys Glu Ser Glu Val Leu 
                245                 250                 255     


Leu Gln Ala Lys Arg Ala Glu Leu Glu Lys Leu Lys Ser Gln Val Thr 
            260                 265                 270         


Ser Gln Gln Gln Glu Met Ala Val Leu Asp Arg Gln Leu Gly His Lys 
        275                 280                 285             


Lys Glu Glu Leu His Leu Leu Gln Gly Ser Met Val Gln Ala Lys Ala 
    290                 295                 300                 


Asp Leu Gln Glu Ala Leu Arg Leu Gly Glu Thr Glu Val Thr Glu Lys 
305                 310                 315                 320 


Cys Asn His Ile Arg Glu Val Lys Ser Leu Leu Glu Glu Leu Ser Phe 
                325                 330                 335     


Gln Lys Gly Glu Leu Asn Val Gln Ile Ser Glu Arg Lys Thr Gln Leu 
            340                 345                 350         


Thr Leu Ile Lys Gln Glu Ile Glu Lys Glu Glu Glu Asn Leu Gln Val 
        355                 360                 365             


Val Leu Arg Gln Met Ser Lys His Lys Thr Glu Leu Lys Asn Ile Leu 
    370                 375                 380                 


Asp Met Leu Gln Leu Glu Asn His Glu Leu Gln Gly Leu Lys Leu Gln 
385                 390                 395                 400 


His Asp Gln Arg Val Ser Glu Leu Glu Lys Thr Gln Val Ala Val Leu 
                405                 410                 415     


Glu Glu Lys Leu Glu Leu Glu Asn Leu Gln Gln Ile Ser Gln Gln Gln 
            420                 425                 430         


Lys Gly Glu Ile Glu Trp Gln Lys Gln Leu Leu Glu Arg Asp Lys Arg 
        435                 440                 445             


Glu Ile Glu Arg Met Thr Ala Glu Ser Arg Ala Leu Gln Ser Cys Val 
    450                 455                 460                 


Glu Cys Leu Ser Lys Glu Lys Glu Asp Leu Gln Glu Lys Cys Asp Ile 
465                 470                 475                 480 


Trp Glu Lys Lys Leu Ala Gln Thr Lys Arg Val Leu Ala Ala Ala Glu 
                485                 490                 495     


Glu Asn Ser Lys Met Glu Gln Ser Asn Leu Glu Lys Leu Glu Leu Asn 
            500                 505                 510         


Val Arg Lys Leu Gln Gln Glu Leu Asp Gln Leu Asn Arg Asp Lys Leu 
        515                 520                 525             


Ser Leu His Asn Asp Ile Ser Ala Met Gln Gln Gln Leu Gln Glu Lys 
    530                 535                 540                 


Arg Glu Ala Val Asn Ser Leu Gln Glu Glu Leu Ala Asn Val Gln Asp 
545                 550                 555                 560 


His Leu Asn Leu Ala Lys Gln Asp Leu Leu His Thr Thr Lys His Gln 
                565                 570                 575     


Asp Val Leu Leu Ser Glu Gln Thr Arg Leu Gln Lys Asp Ile Ser Glu 
            580                 585                 590         


Trp Ala Asn Arg Phe Glu Asp Cys Gln Lys Glu Glu Glu Thr Lys Gln 
        595                 600                 605             


Gln Gln Leu Gln Val Leu Gln Asn Glu Ile Glu Glu Asn Lys Leu Lys 
    610                 615                 620                 


Leu Val Gln Gln Glu Met Met Phe Gln Arg Leu Gln Lys Glu Arg Glu 
625                 630                 635                 640 


Ser Glu Glu Ser Lys Leu Glu Thr Ser Lys Val Thr Leu Lys Glu Gln 
                645                 650                 655     


Gln His Gln Leu Glu Lys Glu Leu Thr Asp Gln Lys Ser Lys Leu Asp 
            660                 665                 670         


Gln Val Leu Ser Lys Val Leu Ala Ala Glu Glu Arg Val Arg Thr Leu 
        675                 680                 685             


Gln Glu Glu Glu Arg Trp Cys Glu Ser Leu Glu Lys Thr Leu Ser Gln 
    690                 695                 700                 


Thr Lys Arg Gln Leu Ser Glu Arg Glu Gln Gln Leu Val Glu Lys Ser 
705                 710                 715                 720 


Gly Glu Leu Leu Ala Leu Gln Lys Glu Ala Asp Ser Met Arg Ala Asp 
                725                 730                 735     


Phe Ser Leu Leu Arg Asn Gln Phe Leu Thr Glu Arg Lys Lys Ala Glu 
            740                 745                 750         


Lys Gln Val Ala Ser Leu Lys Glu Ala Leu Lys Ile Gln Arg Ser Gln 
        755                 760                 765             


Leu Glu Lys Asn Leu Leu Glu Gln Lys Gln Glu Asn Ser Cys Ile Gln 
    770                 775                 780                 


Lys Glu Met Ala Thr Ile Glu Leu Val Ala Gln Asp Asn His Glu Arg 
785                 790                 795                 800 


Ala Arg Arg Leu Met Lys Glu Leu Asn Gln Met Gln Tyr Glu Tyr Thr 
                805                 810                 815     


Glu Leu Lys Lys Gln Met Ala Asn Gln Lys Asp Leu Glu Arg Arg Gln 
            820                 825                 830         


Met Glu Ile Ser Asp Ala Met Arg Thr Leu Lys Ser Glu Val Lys Asp 
        835                 840                 845             


Glu Ile Arg Thr Ser Leu Lys Asn Leu Asn Gln Phe Leu Pro Glu Leu 
    850                 855                 860                 


Pro Ala Asp Leu Glu Ala Ile Leu Glu Arg Asn Glu Asn Leu Glu Gly 
865                 870                 875                 880 


Glu Leu Glu Ser Leu Lys Glu Asn Leu Pro Phe Thr Met Asn Glu Gly 
                885                 890                 895     


Pro Phe Glu Glu Lys Leu Asn Phe Ser Gln Val His Ile Met Asp Glu 
            900                 905                 910         


His Trp Arg Gly Glu Ala Leu Arg Glu Lys Leu Arg His Arg Glu Asp 
        915                 920                 925             


Arg Leu Lys Ala Gln Leu Arg His Cys Met Ser Lys Gln Ala Glu Val 
    930                 935                 940                 


Leu Ile Lys Gly Lys Arg Gln Thr Glu Gly Thr Leu His Ser Leu Arg 
945                 950                 955                 960 


Arg Gln Val Asp Ala Leu Gly Glu Leu Val Thr Ser Thr Ser Ala Asp 
                965                 970                 975     


Ser Ala Ser Ser Pro Ser Leu Ser Gln Leu Glu Ser Ser Leu Thr Glu 
            980                 985                 990         


Asp Ser Gln Leu Gly Gln Asn Gln  Glu Lys Asn Ala Ser  Ala Arg 
        995                 1000                 1005         


<210> 6388
<211> 994
<212> PRT
<213> Homo sapiens

<400> 6388
Met Lys Ala Gln Lys Ser Gly Lys Glu Gln Gln Leu Asp Ile Met Asn 
1               5                   10                  15      


Lys Gln Tyr Gln Gln Leu Glu Ser Arg Leu Asp Glu Ile Leu Ser Arg 
            20                  25                  30          


Ile Ala Lys Glu Thr Glu Glu Ile Lys Asp Leu Glu Glu Gln Leu Thr 
        35                  40                  45              


Glu Gly Gln Ile Ala Ala Asn Glu Ala Leu Lys Lys Asp Leu Glu Gly 
    50                  55                  60                  


Val Ile Ser Gly Leu Gln Glu Tyr Leu Gly Thr Ile Lys Gly Gln Ala 
65                  70                  75                  80  


Thr Gln Ala Gln Asn Glu Cys Arg Lys Leu Arg Asp Glu Lys Glu Thr 
                85                  90                  95      


Leu Leu Gln Arg Leu Thr Glu Val Glu Gln Glu Arg Asp Gln Leu Glu 
            100                 105                 110         


Ile Val Ala Met Asp Ala Glu Asn Met Arg Lys Glu Leu Ala Glu Leu 
        115                 120                 125             


Glu Ser Ala Leu Gln Glu Gln His Glu Val Asn Ala Ser Leu Gln Gln 
    130                 135                 140                 


Thr Gln Gly Asp Leu Ser Ala Tyr Glu Ala Glu Leu Glu Ala Arg Leu 
145                 150                 155                 160 


Asn Leu Arg Asp Ala Glu Ala Asn Gln Leu Lys Glu Glu Leu Glu Lys 
                165                 170                 175     


Val Thr Arg Leu Thr Gln Leu Glu Gln Ser Ala Leu Gln Ala Glu Leu 
            180                 185                 190         


Glu Lys Glu Arg Gln Ala Leu Lys Asn Ala Leu Gly Lys Ala Gln Phe 
        195                 200                 205             


Ser Glu Glu Lys Glu Gln Glu Asn Ser Glu Leu His Ala Lys Leu Lys 
    210                 215                 220                 


His Leu Gln Asp Asp Asn Asn Leu Leu Lys Gln Gln Leu Lys Asp Phe 
225                 230                 235                 240 


Gln Asn His Leu Asn His Val Val Asp Gly Leu Val Arg Pro Glu Glu 
                245                 250                 255     


Val Ala Ala Arg Val Asp Glu Leu Arg Arg Lys Leu Lys Leu Gly Thr 
            260                 265                 270         


Gly Glu Met Asn Ile His Ser Pro Ser Asp Val Leu Gly Lys Ser Leu 
        275                 280                 285             


Ala Asp Leu Gln Lys Gln Phe Ser Glu Ile Leu Ala Arg Ser Lys Trp 
    290                 295                 300                 


Glu Arg Asp Glu Ala Gln Val Arg Glu Arg Lys Leu Gln Glu Glu Met 
305                 310                 315                 320 


Ala Leu Gln Gln Glu Lys Leu Ala Thr Gly Gln Glu Glu Phe Arg Gln 
                325                 330                 335     


Ala Cys Glu Arg Ala Leu Glu Ala Arg Met Asn Phe Asp Lys Arg Gln 
            340                 345                 350         


His Glu Ala Arg Ile Gln Gln Met Glu Asn Glu Ile His Tyr Leu Gln 
        355                 360                 365             


Glu Asn Leu Lys Ser Met Glu Glu Ile Gln Gly Leu Thr Asp Leu Gln 
    370                 375                 380                 


Leu Gln Glu Ala Asp Glu Glu Lys Glu Arg Ile Leu Ala Gln Leu Arg 
385                 390                 395                 400 


Glu Leu Glu Lys Lys Lys Lys Leu Glu Asp Ala Lys Ser Gln Glu Gln 
                405                 410                 415     


Val Phe Gly Leu Asp Lys Glu Leu Lys Lys Leu Lys Lys Ala Val Ala 
            420                 425                 430         


Thr Ser Asp Lys Leu Ala Thr Ala Glu Leu Thr Ile Ala Lys Asp Gln 
        435                 440                 445             


Leu Lys Ser Leu His Gly Thr Val Met Lys Ile Asn Gln Glu Arg Ala 
    450                 455                 460                 


Glu Glu Leu Gln Glu Ala Glu Arg Phe Ser Arg Lys Ala Ala Gln Ala 
465                 470                 475                 480 


Ala Arg Asp Leu Thr Arg Ala Glu Ala Glu Ile Glu Leu Leu Gln Asn 
                485                 490                 495     


Leu Leu Arg Gln Lys Gly Glu Gln Phe Arg Leu Glu Met Glu Lys Thr 
            500                 505                 510         


Gly Val Gly Thr Gly Ala Asn Ser Gln Val Leu Glu Ile Glu Lys Leu 
        515                 520                 525             


Asn Glu Thr Met Glu Arg Gln Arg Thr Glu Ile Ala Arg Leu Gln Asn 
    530                 535                 540                 


Val Leu Asp Leu Thr Gly Ser Asp Asn Lys Gly Gly Phe Glu Asn Val 
545                 550                 555                 560 


Leu Glu Glu Ile Ala Glu Leu Arg Arg Glu Val Ser Tyr Gln Asn Asp 
                565                 570                 575     


Tyr Ile Ser Ser Met Ala Asp Pro Phe Lys Arg Arg Gly Tyr Trp Tyr 
            580                 585                 590         


Phe Met Pro Pro Pro Pro Ser Ser Lys Val Ser Ser His Ser Ser Gln 
        595                 600                 605             


Ala Thr Lys Asp Ser Gly Val Gly Leu Lys Tyr Ser Ala Ser Thr Pro 
    610                 615                 620                 


Val Arg Lys Pro Arg Pro Gly Gln Gln Asp Gly Lys Glu Gly Ser Gln 
625                 630                 635                 640 


Pro Pro Pro Ala Ser Gly Tyr Trp Val Tyr Ser Pro Ile Arg Ser Gly 
                645                 650                 655     


Leu His Lys Leu Phe Pro Ser Arg Asp Ala Asp Ser Gly Gly Asp Ser 
            660                 665                 670         


Gln Glu Glu Ser Glu Leu Asp Asp Gln Glu Glu Pro Pro Phe Val Pro 
        675                 680                 685             


Pro Pro Gly Tyr Met Met Tyr Thr Val Leu Pro Asp Gly Ser Pro Val 
    690                 695                 700                 


Pro Gln Gly Met Ala Leu Tyr Ala Pro Pro Pro Pro Leu Pro Asn Asn 
705                 710                 715                 720 


Ser Arg Pro Leu Thr Pro Gly Thr Val Val Tyr Gly Pro Pro Pro Ala 
                725                 730                 735     


Gly Ala Pro Met Val Tyr Gly Pro Pro Pro Pro Asn Phe Ser Ile Pro 
            740                 745                 750         


Phe Ile Pro Met Gly Val Leu His Cys Asn Val Pro Glu His His Asn 
        755                 760                 765             


Leu Glu Asn Glu Val Ser Arg Leu Glu Asp Ile Met Gln His Leu Lys 
    770                 775                 780                 


Ser Lys Lys Arg Glu Glu Arg Trp Met Arg Ala Ser Lys Arg Gln Ser 
785                 790                 795                 800 


Glu Lys Glu Met Glu Glu Leu His His Asn Ile Asp Asp Leu Leu Gln 
                805                 810                 815     


Glu Lys Lys Ser Leu Glu Cys Glu Val Glu Glu Leu His Arg Thr Val 
            820                 825                 830         


Gln Lys Arg Gln Gln Gln Lys Asp Phe Ile Asp Gly Asn Val Glu Ser 
        835                 840                 845             


Leu Met Thr Glu Leu Glu Ile Glu Lys Ser Leu Lys His His Glu Asp 
    850                 855                 860                 


Ile Val Asp Glu Ile Glu Cys Ile Glu Lys Thr Leu Leu Lys Arg Arg 
865                 870                 875                 880 


Ser Glu Leu Arg Glu Ala Asp Arg Leu Leu Ala Glu Ala Glu Ser Glu 
                885                 890                 895     


Leu Ser Cys Thr Lys Glu Lys Thr Lys Asn Ala Val Glu Lys Phe Thr 
            900                 905                 910         


Asp Ala Lys Arg Ser Leu Leu Gln Thr Glu Ser Asp Ala Glu Glu Leu 
        915                 920                 925             


Glu Arg Arg Ala Gln Glu Thr Ala Val Asn Leu Val Lys Ala Asp Gln 
    930                 935                 940                 


Gln Leu Arg Ser Leu Gln Ala Asp Ala Lys Asp Leu Glu Gln His Lys 
945                 950                 955                 960 


Ile Lys Gln Glu Glu Ile Leu Lys Glu Ile Asn Lys Ile Val Ala Ala 
                965                 970                 975     


Lys Asp Ser Asp Phe Gln Cys Leu Ser Lys Lys Lys Glu Lys Leu Thr 
            980                 985                 990         


Glu Glu 
        


<210> 6389
<211> 1773
<212> PRT
<213> Homo sapiens

<400> 6389
Met Lys Ala Gln Lys Ser Gly Lys Glu Gln Gln Leu Asp Ile Met Asn 
1               5                   10                  15      


Lys Gln Tyr Gln Gln Leu Glu Ser Arg Leu Asp Glu Ile Leu Ser Arg 
            20                  25                  30          


Ile Ala Lys Glu Thr Glu Glu Ile Lys Asp Leu Glu Glu Gln Leu Thr 
        35                  40                  45              


Glu Gly Gln Ile Ala Ala Asn Glu Ala Leu Lys Lys Asp Leu Glu Gly 
    50                  55                  60                  


Val Ile Ser Gly Leu Gln Glu Tyr Leu Gly Thr Ile Lys Gly Gln Ala 
65                  70                  75                  80  


Thr Gln Ala Gln Asn Glu Cys Arg Lys Leu Arg Asp Glu Lys Glu Thr 
                85                  90                  95      


Leu Leu Gln Arg Leu Thr Glu Val Glu Gln Glu Arg Asp Gln Leu Glu 
            100                 105                 110         


Ile Val Ala Met Asp Ala Glu Asn Met Arg Lys Glu Leu Ala Glu Leu 
        115                 120                 125             


Glu Ser Ala Leu Gln Glu Gln His Glu Val Asn Ala Ser Leu Gln Gln 
    130                 135                 140                 


Thr Gln Gly Asp Leu Ser Ala Tyr Glu Ala Glu Leu Glu Ala Arg Leu 
145                 150                 155                 160 


Asn Leu Arg Asp Ala Glu Ala Asn Gln Leu Lys Glu Glu Leu Glu Lys 
                165                 170                 175     


Val Thr Arg Leu Thr Gln Leu Glu Gln Ser Ala Leu Gln Ala Glu Leu 
            180                 185                 190         


Glu Lys Glu Arg Gln Ala Leu Lys Asn Ala Leu Gly Lys Ala Gln Phe 
        195                 200                 205             


Ser Glu Glu Lys Glu Gln Glu Asn Ser Glu Leu His Ala Lys Leu Lys 
    210                 215                 220                 


His Leu Gln Asp Asp Asn Asn Leu Leu Lys Gln Gln Leu Lys Asp Phe 
225                 230                 235                 240 


Gln Asn His Leu Asn His Val Val Asp Gly Leu Val Arg Pro Glu Glu 
                245                 250                 255     


Val Ala Ala Arg Val Asp Glu Leu Arg Arg Lys Leu Lys Leu Gly Thr 
            260                 265                 270         


Gly Glu Met Asn Ile His Ser Pro Ser Asp Val Leu Gly Lys Ser Leu 
        275                 280                 285             


Ala Asp Leu Gln Lys Gln Phe Ser Glu Ile Leu Ala Arg Ser Lys Trp 
    290                 295                 300                 


Glu Arg Asp Glu Ala Gln Val Arg Glu Arg Lys Leu Gln Glu Glu Met 
305                 310                 315                 320 


Ala Leu Gln Gln Glu Lys Leu Ala Thr Gly Gln Glu Glu Phe Arg Gln 
                325                 330                 335     


Ala Cys Glu Arg Ala Leu Glu Ala Arg Met Asn Phe Asp Lys Arg Gln 
            340                 345                 350         


His Glu Ala Arg Ile Gln Gln Met Glu Asn Glu Ile His Tyr Leu Gln 
        355                 360                 365             


Glu Asn Leu Lys Ser Met Glu Glu Ile Gln Gly Leu Thr Asp Leu Gln 
    370                 375                 380                 


Leu Gln Glu Ala Asp Glu Glu Lys Glu Arg Ile Leu Ala Gln Leu Arg 
385                 390                 395                 400 


Glu Leu Glu Lys Lys Lys Lys Leu Glu Asp Ala Lys Ser Gln Glu Gln 
                405                 410                 415     


Val Phe Gly Leu Asp Lys Glu Leu Lys Lys Leu Lys Lys Ala Val Ala 
            420                 425                 430         


Thr Ser Asp Lys Leu Ala Thr Ala Glu Leu Thr Ile Ala Lys Asp Gln 
        435                 440                 445             


Leu Lys Ser Leu His Gly Thr Val Met Lys Ile Asn Gln Glu Arg Ala 
    450                 455                 460                 


Glu Glu Leu Gln Glu Ala Glu Arg Phe Ser Arg Lys Ala Ala Gln Ala 
465                 470                 475                 480 


Ala Arg Asp Leu Thr Arg Ala Glu Ala Glu Ile Glu Leu Leu Gln Asn 
                485                 490                 495     


Leu Leu Arg Gln Lys Gly Glu Gln Phe Arg Leu Glu Met Glu Lys Thr 
            500                 505                 510         


Gly Val Gly Thr Gly Ala Asn Ser Gln Val Leu Glu Ile Glu Lys Leu 
        515                 520                 525             


Asn Glu Thr Met Glu Arg Gln Arg Thr Glu Ile Ala Arg Leu Gln Asn 
    530                 535                 540                 


Val Leu Asp Leu Thr Gly Ser Asp Asn Lys Gly Gly Phe Glu Asn Val 
545                 550                 555                 560 


Leu Glu Glu Ile Ala Glu Leu Arg Arg Glu Val Ser Tyr Gln Asn Asp 
                565                 570                 575     


Tyr Ile Ser Ser Met Ala Asp Pro Phe Lys Arg Arg Gly Tyr Trp Tyr 
            580                 585                 590         


Phe Met Pro Pro Pro Pro Ser Ser Lys Val Ser Ser His Ser Ser Gln 
        595                 600                 605             


Ala Thr Lys Asp Ser Gly Val Gly Leu Lys Tyr Ser Ala Ser Thr Pro 
    610                 615                 620                 


Val Arg Lys Pro Arg Pro Gly Gln Gln Asp Gly Lys Glu Gly Ser Gln 
625                 630                 635                 640 


Pro Pro Pro Ala Ser Gly Tyr Trp Val Tyr Ser Pro Ile Arg Ser Gly 
                645                 650                 655     


Leu His Lys Leu Phe Pro Ser Arg Asp Ala Asp Ser Gly Gly Asp Ser 
            660                 665                 670         


Gln Glu Glu Ser Glu Leu Asp Asp Gln Glu Glu Pro Pro Phe Val Pro 
        675                 680                 685             


Pro Pro Gly Tyr Met Met Tyr Thr Val Leu Pro Asp Gly Ser Pro Val 
    690                 695                 700                 


Pro Gln Gly Met Ala Leu Tyr Ala Pro Pro Pro Pro Leu Pro Asn Asn 
705                 710                 715                 720 


Ser Arg Pro Leu Thr Pro Gly Thr Val Val Tyr Gly Pro Pro Pro Ala 
                725                 730                 735     


Gly Ala Pro Met Val Tyr Gly Pro Pro Pro Pro Asn Phe Ser Ile Pro 
            740                 745                 750         


Phe Ile Pro Met Gly Val Leu His Cys Asn Val Pro Glu His His Asn 
        755                 760                 765             


Leu Glu Asn Glu Val Ser Arg Leu Glu Asp Ile Met Gln His Leu Lys 
    770                 775                 780                 


Ser Lys Lys Arg Glu Glu Arg Trp Met Arg Ala Ser Lys Arg Gln Ser 
785                 790                 795                 800 


Glu Lys Glu Met Glu Glu Leu His His Asn Ile Asp Asp Leu Leu Gln 
                805                 810                 815     


Glu Lys Lys Ser Leu Glu Cys Glu Val Glu Glu Leu His Arg Thr Val 
            820                 825                 830         


Gln Lys Arg Gln Gln Gln Lys Asp Phe Ile Asp Gly Asn Val Glu Ser 
        835                 840                 845             


Leu Met Thr Glu Leu Glu Ile Glu Lys Ser Leu Lys His His Glu Asp 
    850                 855                 860                 


Ile Val Asp Glu Ile Glu Cys Ile Glu Lys Thr Leu Leu Lys Arg Arg 
865                 870                 875                 880 


Ser Glu Leu Arg Glu Ala Asp Arg Leu Leu Ala Glu Ala Glu Ser Glu 
                885                 890                 895     


Leu Ser Cys Thr Lys Glu Lys Thr Lys Asn Ala Val Glu Lys Phe Thr 
            900                 905                 910         


Asp Ala Lys Arg Ser Leu Leu Gln Thr Glu Ser Asp Ala Glu Glu Leu 
        915                 920                 925             


Glu Arg Arg Ala Gln Glu Thr Ala Val Asn Leu Val Lys Ala Asp Gln 
    930                 935                 940                 


Gln Leu Arg Ser Leu Gln Ala Asp Ala Lys Asp Leu Glu Gln His Lys 
945                 950                 955                 960 


Ile Lys Gln Glu Glu Ile Leu Lys Glu Ile Asn Lys Ile Val Ala Ala 
                965                 970                 975     


Lys Asp Ser Asp Phe Gln Cys Leu Ser Lys Lys Lys Glu Lys Leu Thr 
            980                 985                 990         


Glu Glu Leu Gln Lys Leu Gln Lys  Asp Ile Glu Met Ala  Glu Arg Asn 
        995                 1000                 1005             


Glu Asp  His His Leu Gln Val  Leu Lys Glu Ser Glu  Val Leu Leu 
    1010                 1015                 1020             


Gln Ala  Lys Arg Ala Glu Leu  Glu Lys Leu Lys Ser  Gln Val Thr 
    1025                 1030                 1035             


Ser Gln  Gln Gln Glu Met Ala  Val Leu Asp Arg Gln  Leu Gly His 
    1040                 1045                 1050             


Lys Lys  Glu Glu Leu His Leu  Leu Gln Gly Ser Met  Val Gln Ala 
    1055                 1060                 1065             


Lys Ala  Asp Leu Gln Glu Ala  Leu Arg Leu Gly Glu  Thr Glu Val 
    1070                 1075                 1080             


Thr Glu  Lys Cys Asn His Ile  Arg Glu Val Lys Ser  Leu Leu Glu 
    1085                 1090                 1095             


Glu Leu  Ser Phe Gln Lys Gly  Glu Leu Asn Val Gln  Ile Ser Glu 
    1100                 1105                 1110             


Arg Lys  Thr Gln Leu Thr Leu  Ile Lys Gln Glu Ile  Glu Lys Glu 
    1115                 1120                 1125             


Glu Glu  Asn Leu Gln Val Val  Leu Arg Gln Met Ser  Lys His Lys 
    1130                 1135                 1140             


Thr Glu  Leu Lys Asn Ile Leu  Asp Met Leu Gln Leu  Glu Asn His 
    1145                 1150                 1155             


Glu Leu  Gln Gly Leu Lys Leu  Gln His Asp Gln Arg  Val Ser Glu 
    1160                 1165                 1170             


Leu Glu  Lys Thr Gln Val Ala  Val Leu Glu Glu Lys  Leu Glu Leu 
    1175                 1180                 1185             


Glu Asn  Leu Gln Gln Ile Ser  Gln Gln Gln Lys Gly  Glu Ile Glu 
    1190                 1195                 1200             


Trp Gln  Lys Gln Leu Leu Glu  Arg Asp Lys Arg Glu  Ile Glu Arg 
    1205                 1210                 1215             


Met Thr  Ala Glu Ser Arg Ala  Leu Gln Ser Cys Val  Glu Cys Leu 
    1220                 1225                 1230             


Ser Lys  Glu Lys Glu Asp Leu  Gln Glu Lys Cys Asp  Ile Trp Glu 
    1235                 1240                 1245             


Lys Lys  Leu Ala Gln Thr Lys  Arg Val Leu Ala Ala  Ala Glu Glu 
    1250                 1255                 1260             


Asn Ser  Lys Met Glu Gln Ser  Asn Leu Glu Lys Leu  Glu Leu Asn 
    1265                 1270                 1275             


Val Arg  Lys Leu Gln Gln Glu  Leu Asp Gln Leu Asn  Arg Asp Lys 
    1280                 1285                 1290             


Leu Ser  Leu His Asn Asp Ile  Ser Ala Met Gln Gln  Gln Leu Gln 
    1295                 1300                 1305             


Glu Lys  Arg Glu Ala Val Asn  Ser Leu Gln Glu Glu  Leu Ala Asn 
    1310                 1315                 1320             


Val Gln  Asp His Leu Asn Leu  Ala Lys Gln Asp Leu  Leu His Thr 
    1325                 1330                 1335             


Thr Lys  His Gln Asp Val Leu  Leu Ser Glu Gln Thr  Arg Leu Gln 
    1340                 1345                 1350             


Lys Asp  Ile Ser Glu Trp Ala  Asn Arg Phe Glu Asp  Cys Gln Lys 
    1355                 1360                 1365             


Glu Glu  Glu Thr Lys Gln Gln  Gln Leu Gln Val Leu  Gln Asn Glu 
    1370                 1375                 1380             


Ile Glu  Glu Asn Lys Leu Lys  Leu Val Gln Gln Glu  Met Met Phe 
    1385                 1390                 1395             


Gln Arg  Leu Gln Lys Glu Arg  Glu Ser Glu Glu Ser  Lys Leu Glu 
    1400                 1405                 1410             


Thr Ser  Lys Val Thr Leu Lys  Glu Gln Gln His Gln  Leu Glu Lys 
    1415                 1420                 1425             


Glu Leu  Thr Asp Gln Lys Ser  Lys Leu Asp Gln Val  Leu Ser Lys 
    1430                 1435                 1440             


Val Leu  Ala Ala Glu Glu Arg  Val Arg Thr Leu Gln  Glu Glu Glu 
    1445                 1450                 1455             


Arg Trp  Cys Glu Ser Leu Glu  Lys Thr Leu Ser Gln  Thr Lys Arg 
    1460                 1465                 1470             


Gln Leu  Ser Glu Arg Glu Gln  Gln Leu Val Glu Lys  Ser Gly Glu 
    1475                 1480                 1485             


Leu Leu  Ala Leu Gln Lys Glu  Ala Asp Ser Met Arg  Ala Asp Phe 
    1490                 1495                 1500             


Ser Leu  Leu Arg Asn Gln Phe  Leu Thr Glu Arg Lys  Lys Ala Glu 
    1505                 1510                 1515             


Lys Gln  Val Ala Ser Leu Lys  Glu Ala Leu Lys Ile  Gln Arg Ser 
    1520                 1525                 1530             


Gln Leu  Glu Lys Asn Leu Leu  Glu Gln Lys Gln Glu  Asn Ser Cys 
    1535                 1540                 1545             


Ile Gln  Lys Glu Met Ala Thr  Ile Glu Leu Val Ala  Gln Asp Asn 
    1550                 1555                 1560             


His Glu  Arg Ala Arg Arg Leu  Met Lys Glu Leu Asn  Gln Met Gln 
    1565                 1570                 1575             


Tyr Glu  Tyr Thr Glu Leu Lys  Lys Gln Met Ala Asn  Gln Lys Asp 
    1580                 1585                 1590             


Leu Glu  Arg Arg Gln Met Glu  Ile Ser Asp Ala Met  Arg Thr Leu 
    1595                 1600                 1605             


Lys Ser  Glu Val Lys Asp Glu  Ile Arg Thr Ser Leu  Lys Asn Leu 
    1610                 1615                 1620             


Asn Gln  Phe Leu Pro Glu Leu  Pro Ala Asp Leu Glu  Ala Ile Leu 
    1625                 1630                 1635             


Glu Arg  Asn Glu Asn Leu Glu  Gly Glu Leu Glu Ser  Leu Lys Glu 
    1640                 1645                 1650             


Asn Leu  Pro Phe Thr Met Asn  Glu Gly Pro Phe Glu  Glu Lys Leu 
    1655                 1660                 1665             


Asn Phe  Ser Gln Val His Ile  Met Asp Glu His Trp  Arg Gly Glu 
    1670                 1675                 1680             


Ala Leu  Arg Glu Lys Leu Arg  His Arg Glu Asp Arg  Leu Lys Ala 
    1685                 1690                 1695             


Gln Leu  Arg His Cys Met Ser  Lys Gln Ala Glu Val  Leu Ile Lys 
    1700                 1705                 1710             


Gly Lys  Arg Gln Thr Glu Gly  Thr Leu His Ser Leu  Arg Arg Gln 
    1715                 1720                 1725             


Val Asp  Ala Leu Gly Glu Leu  Val Thr Ser Thr Ser  Ala Asp Ser 
    1730                 1735                 1740             


Ala Ser  Ser Pro Ser Leu Ser  Gln Leu Glu Ser Ser  Leu Thr Glu 
    1745                 1750                 1755             


Asp Ser  Gln Leu Gly Gln Asn  Gln Glu Lys Asn Ala  Ser Ala Arg 
    1760                 1765                 1770             


<210> 6390
<211> 828
<212> PRT
<213> Homo sapiens

<400> 6390
Met Glu Lys Gln Lys Gln Glu Ile Ala Gly Lys Gln Lys Glu Ile Lys 
1               5                   10                  15      


Asp Leu Gln Ile Ala Ile Asp Ser Leu Asp Ser Lys Asp Pro Lys His 
            20                  25                  30          


Ser His Met Lys Ala Gln Lys Ser Gly Lys Glu Gln Gln Leu Asp Ile 
        35                  40                  45              


Met Asn Lys Gln Tyr Gln Gln Leu Glu Ser Arg Leu Asp Glu Ile Leu 
    50                  55                  60                  


Ser Arg Ile Ala Lys Glu Thr Glu Glu Ile Lys Asp Leu Glu Glu Gln 
65                  70                  75                  80  


Leu Thr Glu Gly Gln Ile Ala Ala Asn Glu Ala Leu Lys Lys Asp Leu 
                85                  90                  95      


Glu Gly Val Ile Ser Gly Leu Gln Glu Tyr Leu Gly Thr Ile Lys Gly 
            100                 105                 110         


Gln Ala Thr Gln Ala Gln Asn Glu Cys Arg Lys Leu Arg Asp Glu Lys 
        115                 120                 125             


Glu Thr Leu Leu Gln Arg Leu Thr Glu Val Glu Gln Glu Arg Asp Gln 
    130                 135                 140                 


Leu Glu Ile Val Ala Met Asp Ala Glu Asn Met Arg Lys Glu Leu Ala 
145                 150                 155                 160 


Glu Leu Glu Ser Ala Leu Gln Glu Gln His Glu Val Asn Ala Ser Leu 
                165                 170                 175     


Gln Gln Thr Gln Gly Asp Leu Ser Ala Tyr Glu Ala Glu Leu Glu Ala 
            180                 185                 190         


Arg Leu Asn Leu Arg Asp Ala Glu Ala Asn Gln Leu Lys Glu Glu Leu 
        195                 200                 205             


Glu Lys Val Thr Arg Leu Thr Gln Leu Glu Gln Ser Ala Leu Gln Ala 
    210                 215                 220                 


Glu Leu Glu Lys Glu Arg Gln Ala Leu Lys Asn Ala Leu Gly Lys Ala 
225                 230                 235                 240 


Gln Phe Ser Glu Glu Lys Glu Gln Glu Asn Ser Glu Leu His Ala Lys 
                245                 250                 255     


Leu Lys His Leu Gln Asp Asp Asn Asn Leu Leu Lys Gln Gln Leu Lys 
            260                 265                 270         


Asp Phe Gln Asn His Leu Asn His Val Val Asp Gly Leu Val Arg Pro 
        275                 280                 285             


Glu Glu Val Ala Ala Arg Val Asp Glu Leu Arg Arg Lys Leu Lys Leu 
    290                 295                 300                 


Gly Thr Gly Glu Met Asn Ile His Ser Pro Ser Asp Val Leu Gly Lys 
305                 310                 315                 320 


Ser Leu Ala Asp Leu Gln Lys Gln Phe Ser Glu Ile Leu Ala Arg Ser 
                325                 330                 335     


Lys Trp Glu Arg Asp Glu Ala Gln Val Arg Glu Arg Lys Leu Gln Glu 
            340                 345                 350         


Glu Met Ala Leu Gln Gln Glu Lys Leu Ala Thr Gly Gln Glu Glu Phe 
        355                 360                 365             


Arg Gln Ala Cys Glu Arg Ala Leu Glu Ala Arg Met Asn Phe Asp Lys 
    370                 375                 380                 


Arg Gln His Glu Ala Arg Ile Gln Gln Met Glu Asn Glu Ile His Tyr 
385                 390                 395                 400 


Leu Gln Glu Asn Leu Lys Ser Met Glu Glu Ile Gln Gly Leu Thr Asp 
                405                 410                 415     


Leu Gln Leu Gln Glu Ala Asp Glu Glu Lys Glu Arg Ile Leu Ala Gln 
            420                 425                 430         


Leu Arg Glu Leu Glu Lys Lys Lys Lys Leu Glu Asp Ala Lys Ser Gln 
        435                 440                 445             


Glu Gln Val Phe Gly Leu Asp Lys Glu Leu Lys Lys Leu Lys Lys Ala 
    450                 455                 460                 


Val Ala Thr Ser Asp Lys Leu Ala Thr Ala Glu Leu Thr Ile Ala Lys 
465                 470                 475                 480 


Asp Gln Leu Lys Ser Leu His Gly Thr Val Met Lys Ile Asn Gln Glu 
                485                 490                 495     


Arg Ala Glu Glu Leu Gln Glu Ala Glu Arg Phe Ser Arg Lys Ala Ala 
            500                 505                 510         


Gln Ala Ala Arg Asp Leu Thr Arg Ala Glu Ala Glu Ile Glu Leu Leu 
        515                 520                 525             


Gln Asn Leu Leu Arg Gln Lys Gly Glu Gln Phe Arg Leu Glu Met Glu 
    530                 535                 540                 


Lys Thr Gly Val Gly Thr Gly Ala Asn Ser Gln Val Leu Glu Ile Glu 
545                 550                 555                 560 


Lys Leu Asn Glu Thr Met Glu Arg Gln Arg Thr Glu Ile Ala Arg Leu 
                565                 570                 575     


Gln Asn Val Leu Asp Leu Thr Gly Ser Asp Asn Lys Gly Gly Phe Glu 
            580                 585                 590         


Asn Val Leu Glu Glu Ile Ala Glu Leu Arg Arg Glu Val Ser Tyr Gln 
        595                 600                 605             


Asn Asp Tyr Ile Ser Ser Met Ala Asp Pro Phe Lys Arg Arg Gly Tyr 
    610                 615                 620                 


Trp Tyr Phe Met Pro Pro Pro Pro Ser Ser Lys Val Ser Ser His Ser 
625                 630                 635                 640 


Ser Gln Ala Thr Lys Asp Ser Gly Val Gly Leu Lys Tyr Ser Ala Ser 
                645                 650                 655     


Thr Pro Val Arg Lys Pro Arg Pro Gly Gln Gln Asp Gly Lys Glu Gly 
            660                 665                 670         


Ser Gln Pro Pro Pro Ala Ser Gly Tyr Trp Val Tyr Ser Pro Ile Arg 
        675                 680                 685             


Ser Gly Leu His Lys Leu Phe Pro Ser Arg Asp Ala Asp Ser Gly Gly 
    690                 695                 700                 


Asp Ser Gln Glu Glu Ser Glu Leu Asp Asp Gln Glu Glu Pro Pro Phe 
705                 710                 715                 720 


Val Pro Pro Pro Gly Tyr Met Met Tyr Thr Val Leu Pro Asp Gly Ser 
                725                 730                 735     


Pro Val Pro Gln Gly Met Ala Leu Tyr Ala Pro Pro Pro Pro Leu Pro 
            740                 745                 750         


Asn Asn Ser Arg Pro Leu Thr Pro Gly Thr Val Val Tyr Gly Pro Pro 
        755                 760                 765             


Pro Ala Gly Ala Pro Met Val Tyr Gly Pro Pro Pro Pro Asn Phe Ser 
    770                 775                 780                 


Ile Pro Phe Ile Pro Met Gly Val Leu His Cys Asn Val Pro Glu His 
785                 790                 795                 800 


His Asn Leu Val Ser Gly Lys Thr Tyr Asn Ser Leu Ser Thr Leu Leu 
                805                 810                 815     


Pro Trp Val Thr Asp Lys Val Ile Tyr Leu Met Ser 
            820                 825             


<210> 6391
<211> 2325
<212> PRT
<213> Homo sapiens

<400> 6391
Met Lys Lys Gly Ser Gln Gln Lys Ile Phe Ser Lys Ala Lys Ile Pro 
1               5                   10                  15      


Ser Ser Ser His Ser Pro Ile Pro Ser Ser Met Ser Asn Met Arg Ser 
            20                  25                  30          


Arg Ser Leu Ser Pro Leu Ile Gly Ser Glu Thr Leu Pro Phe His Ser 
        35                  40                  45              


Gly Gly Gln Trp Cys Glu Gln Val Glu Ile Ala Asp Glu Asn Asn Met 
    50                  55                  60                  


Leu Leu Asp Tyr Gln Asp His Lys Gly Ala Asp Ser His Ala Gly Val 
65                  70                  75                  80  


Arg Tyr Ile Thr Glu Ala Leu Ile Lys Lys Leu Thr Lys Gln Asp Asn 
                85                  90                  95      


Leu Ala Leu Ile Lys Ser Leu Asn Leu Ser Leu Ser Lys Asp Gly Gly 
            100                 105                 110         


Lys Lys Phe Lys Tyr Ile Glu Asn Leu Glu Lys Cys Val Lys Leu Glu 
        115                 120                 125             


Val Leu Asn Leu Ser Tyr Asn Leu Ile Gly Lys Ile Glu Lys Leu Asp 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Leu Asn Leu Ser Tyr Asn Lys Ile Ser 
145                 150                 155                 160 


Lys Ile Glu Gly Ile Glu Asn Met Cys Asn Leu Gln Lys Leu Asn Leu 
                165                 170                 175     


Ala Gly Asn Glu Ile Glu His Ile Pro Val Trp Leu Gly Lys Lys Leu 
            180                 185                 190         


Lys Ser Leu Arg Val Leu Asn Leu Lys Gly Asn Lys Ile Ser Ser Leu 
        195                 200                 205             


Gln Asp Ile Ser Lys Leu Lys Pro Leu Gln Asp Leu Ile Ser Leu Ile 
    210                 215                 220                 


Leu Val Glu Asn Pro Val Val Thr Leu Pro His Tyr Leu Gln Phe Thr 
225                 230                 235                 240 


Ile Phe His Leu Arg Ser Leu Glu Ser Leu Glu Gly Gln Pro Val Thr 
                245                 250                 255     


Thr Gln Asp Arg Gln Glu Ala Phe Glu Arg Phe Ser Leu Glu Glu Val 
            260                 265                 270         


Glu Arg Leu Glu Arg Asp Leu Glu Lys Lys Met Ile Glu Thr Glu Glu 
        275                 280                 285             


Leu Lys Ser Lys Gln Thr Arg Phe Leu Glu Glu Ile Lys Asn Gln Asp 
    290                 295                 300                 


Lys Leu Asn Lys Ser Leu Lys Glu Glu Ala Met Leu Gln Lys Gln Ser 
305                 310                 315                 320 


Cys Glu Glu Leu Lys Ser Asp Leu Asn Thr Lys Asn Glu Leu Leu Lys 
                325                 330                 335     


Gln Lys Thr Ile Glu Leu Thr Arg Ala Cys Gln Lys Gln Tyr Glu Leu 
            340                 345                 350         


Glu Gln Glu Leu Ala Phe Tyr Lys Ile Asp Ala Lys Phe Glu Pro Leu 
        355                 360                 365             


Asn Tyr Tyr Pro Ser Glu Tyr Ala Glu Ile Asp Lys Ala Pro Asp Glu 
    370                 375                 380                 


Ser Pro Tyr Ile Gly Lys Ser Arg Tyr Lys Arg Asn Met Phe Ala Thr 
385                 390                 395                 400 


Glu Ser Tyr Ile Ile Asp Ser Ala Gln Ala Val Gln Ile Lys Lys Met 
                405                 410                 415     


Glu Pro Asp Glu Gln Leu Arg Asn Asp His Met Asn Leu Arg Gly His 
            420                 425                 430         


Thr Pro Leu Asp Thr Gln Leu Glu Asp Lys Glu Lys Lys Ile Ser Ala 
        435                 440                 445             


Ala Gln Thr Arg Leu Ser Glu Leu His Asp Glu Ile Glu Lys Ala Glu 
    450                 455                 460                 


Gln Gln Ile Leu Arg Ala Thr Glu Glu Phe Lys Gln Leu Glu Glu Ala 
465                 470                 475                 480 


Ile Gln Leu Lys Lys Ile Ser Glu Ala Gly Lys Asp Leu Leu Tyr Lys 
                485                 490                 495     


Gln Leu Ser Gly Arg Leu Gln Leu Val Asn Lys Leu Arg Gln Glu Ala 
            500                 505                 510         


Leu Asp Leu Glu Leu Gln Met Glu Lys Gln Lys Gln Glu Ile Ala Gly 
        515                 520                 525             


Lys Gln Lys Glu Ile Lys Asp Leu Gln Ile Ala Ile Asp Ser Leu Asp 
    530                 535                 540                 


Ser Lys Asp Pro Lys His Ser His Met Lys Ala Gln Lys Ser Gly Lys 
545                 550                 555                 560 


Glu Gln Gln Leu Asp Ile Met Asn Lys Gln Tyr Gln Gln Leu Glu Ser 
                565                 570                 575     


Arg Leu Asp Glu Ile Leu Ser Arg Ile Ala Lys Glu Thr Glu Glu Ile 
            580                 585                 590         


Lys Asp Leu Glu Glu Gln Leu Thr Glu Gly Gln Ile Ala Ala Asn Glu 
        595                 600                 605             


Ala Leu Lys Lys Asp Leu Glu Gly Val Ile Ser Gly Leu Gln Glu Tyr 
    610                 615                 620                 


Leu Gly Thr Ile Lys Gly Gln Ala Thr Gln Ala Gln Asn Glu Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Asp Glu Lys Glu Thr Leu Leu Gln Arg Leu Thr Glu Val 
                645                 650                 655     


Glu Gln Glu Arg Asp Gln Leu Glu Ile Val Ala Met Asp Ala Glu Asn 
            660                 665                 670         


Met Arg Lys Glu Leu Ala Glu Leu Glu Ser Ala Leu Gln Glu Gln His 
        675                 680                 685             


Glu Val Asn Ala Ser Leu Gln Gln Thr Gln Gly Asp Leu Ser Ala Tyr 
    690                 695                 700                 


Glu Ala Glu Leu Glu Ala Arg Leu Asn Leu Arg Asp Ala Glu Ala Asn 
705                 710                 715                 720 


Gln Leu Lys Glu Glu Leu Glu Lys Val Thr Arg Leu Thr Gln Leu Glu 
                725                 730                 735     


Gln Ser Ala Leu Gln Ala Glu Leu Glu Lys Glu Arg Gln Ala Leu Lys 
            740                 745                 750         


Asn Ala Leu Gly Lys Ala Gln Phe Ser Glu Glu Lys Glu Gln Glu Asn 
        755                 760                 765             


Ser Glu Leu His Ala Lys Leu Lys His Leu Gln Asp Asp Asn Asn Leu 
    770                 775                 780                 


Leu Lys Gln Gln Leu Lys Asp Phe Gln Asn His Leu Asn His Val Val 
785                 790                 795                 800 


Asp Gly Leu Val Arg Pro Glu Glu Val Ala Ala Arg Val Asp Glu Leu 
                805                 810                 815     


Arg Arg Lys Leu Lys Leu Gly Thr Gly Glu Met Asn Ile His Ser Pro 
            820                 825                 830         


Ser Asp Val Leu Gly Lys Ser Leu Ala Asp Leu Gln Lys Gln Phe Ser 
        835                 840                 845             


Glu Ile Leu Ala Arg Ser Lys Trp Glu Arg Asp Glu Ala Gln Val Arg 
    850                 855                 860                 


Glu Arg Lys Leu Gln Glu Glu Met Ala Leu Gln Gln Glu Lys Leu Ala 
865                 870                 875                 880 


Thr Gly Gln Glu Glu Phe Arg Gln Ala Cys Glu Arg Ala Leu Glu Ala 
                885                 890                 895     


Arg Met Asn Phe Asp Lys Arg Gln His Glu Ala Arg Ile Gln Gln Met 
            900                 905                 910         


Glu Asn Glu Ile His Tyr Leu Gln Glu Asn Leu Lys Ser Met Glu Glu 
        915                 920                 925             


Ile Gln Gly Leu Thr Asp Leu Gln Leu Gln Glu Ala Asp Glu Glu Lys 
    930                 935                 940                 


Glu Arg Ile Leu Ala Gln Leu Arg Glu Leu Glu Lys Lys Lys Lys Leu 
945                 950                 955                 960 


Glu Asp Ala Lys Ser Gln Glu Gln Val Phe Gly Leu Asp Lys Glu Leu 
                965                 970                 975     


Lys Lys Leu Lys Lys Ala Val Ala Thr Ser Asp Lys Leu Ala Thr Ala 
            980                 985                 990         


Glu Leu Thr Ile Ala Lys Asp Gln  Leu Lys Ser Leu His  Gly Thr Val 
        995                 1000                 1005             


Met Lys  Ile Asn Gln Glu Arg  Ala Glu Glu Leu Gln  Glu Ala Glu 
    1010                 1015                 1020             


Arg Phe  Ser Arg Lys Ala Ala  Gln Ala Ala Arg Asp  Leu Thr Arg 
    1025                 1030                 1035             


Ala Glu  Ala Glu Ile Glu Leu  Leu Gln Asn Leu Leu  Arg Gln Lys 
    1040                 1045                 1050             


Gly Glu  Gln Phe Arg Leu Glu  Met Glu Lys Thr Gly  Val Gly Thr 
    1055                 1060                 1065             


Gly Ala  Asn Ser Gln Val Leu  Glu Ile Glu Lys Leu  Asn Glu Thr 
    1070                 1075                 1080             


Met Glu  Arg Gln Arg Thr Glu  Ile Ala Arg Leu Gln  Asn Val Leu 
    1085                 1090                 1095             


Asp Leu  Thr Gly Ser Asp Asn  Lys Gly Gly Phe Glu  Asn Val Leu 
    1100                 1105                 1110             


Glu Glu  Ile Ala Glu Leu Arg  Arg Glu Val Ser Tyr  Gln Asn Asp 
    1115                 1120                 1125             


Tyr Ile  Ser Ser Met Ala Asp  Pro Phe Lys Arg Arg  Gly Tyr Trp 
    1130                 1135                 1140             


Tyr Phe  Met Pro Pro Pro Pro  Ser Ser Lys Val Ser  Ser His Ser 
    1145                 1150                 1155             


Ser Gln  Ala Thr Lys Asp Ser  Gly Val Gly Leu Lys  Tyr Ser Ala 
    1160                 1165                 1170             


Ser Thr  Pro Val Arg Lys Pro  Arg Pro Gly Gln Gln  Asp Gly Lys 
    1175                 1180                 1185             


Glu Gly  Ser Gln Pro Pro Pro  Ala Ser Gly Tyr Trp  Val Tyr Ser 
    1190                 1195                 1200             


Pro Ile  Arg Ser Gly Leu His  Lys Leu Phe Pro Ser  Arg Asp Ala 
    1205                 1210                 1215             


Asp Ser  Gly Gly Asp Ser Gln  Glu Glu Ser Glu Leu  Asp Asp Gln 
    1220                 1225                 1230             


Glu Glu  Pro Pro Phe Val Pro  Pro Pro Gly Tyr Met  Met Tyr Thr 
    1235                 1240                 1245             


Val Leu  Pro Asp Gly Ser Pro  Val Pro Gln Gly Met  Ala Leu Tyr 
    1250                 1255                 1260             


Ala Pro  Pro Pro Pro Leu Pro  Asn Asn Ser Arg Pro  Leu Thr Pro 
    1265                 1270                 1275             


Gly Thr  Val Val Tyr Gly Pro  Pro Pro Ala Gly Ala  Pro Met Val 
    1280                 1285                 1290             


Tyr Gly  Pro Pro Pro Pro Asn  Phe Ser Ile Pro Phe  Ile Pro Met 
    1295                 1300                 1305             


Gly Val  Leu His Cys Asn Val  Pro Glu His His Asn  Leu Glu Asn 
    1310                 1315                 1320             


Glu Val  Ser Arg Leu Glu Asp  Ile Met Gln His Leu  Lys Ser Lys 
    1325                 1330                 1335             


Lys Arg  Glu Glu Arg Trp Met  Arg Ala Ser Lys Arg  Gln Ser Glu 
    1340                 1345                 1350             


Lys Glu  Met Glu Glu Leu His  His Asn Ile Asp Asp  Leu Leu Gln 
    1355                 1360                 1365             


Glu Lys  Lys Ser Leu Glu Cys  Glu Val Glu Glu Leu  His Arg Thr 
    1370                 1375                 1380             


Val Gln  Lys Arg Gln Gln Gln  Lys Asp Phe Ile Asp  Gly Asn Val 
    1385                 1390                 1395             


Glu Ser  Leu Met Thr Glu Leu  Glu Ile Glu Lys Ser  Leu Lys His 
    1400                 1405                 1410             


His Glu  Asp Ile Val Asp Glu  Ile Glu Cys Ile Glu  Lys Thr Leu 
    1415                 1420                 1425             


Leu Lys  Arg Arg Ser Glu Leu  Arg Glu Ala Asp Arg  Leu Leu Ala 
    1430                 1435                 1440             


Glu Ala  Glu Ser Glu Leu Ser  Cys Thr Lys Glu Lys  Thr Lys Asn 
    1445                 1450                 1455             


Ala Val  Glu Lys Phe Thr Asp  Ala Lys Arg Ser Leu  Leu Gln Thr 
    1460                 1465                 1470             


Glu Ser  Asp Ala Glu Glu Leu  Glu Arg Arg Ala Gln  Glu Thr Ala 
    1475                 1480                 1485             


Val Asn  Leu Val Lys Ala Asp  Gln Gln Leu Arg Ser  Leu Gln Ala 
    1490                 1495                 1500             


Asp Ala  Lys Asp Leu Glu Gln  His Lys Ile Lys Gln  Glu Glu Ile 
    1505                 1510                 1515             


Leu Lys  Glu Ile Asn Lys Ile  Val Ala Ala Lys Asp  Ser Asp Phe 
    1520                 1525                 1530             


Gln Cys  Leu Ser Lys Lys Lys  Glu Lys Leu Thr Glu  Glu Leu Gln 
    1535                 1540                 1545             


Lys Leu  Gln Lys Asp Ile Glu  Met Ala Glu Arg Asn  Glu Asp His 
    1550                 1555                 1560             


His Leu  Gln Val Leu Lys Glu  Ser Glu Val Leu Leu  Gln Ala Lys 
    1565                 1570                 1575             


Arg Ala  Glu Leu Glu Lys Leu  Lys Ser Gln Val Thr  Ser Gln Gln 
    1580                 1585                 1590             


Gln Glu  Met Ala Val Leu Asp  Arg Gln Leu Gly His  Lys Lys Glu 
    1595                 1600                 1605             


Glu Leu  His Leu Leu Gln Gly  Ser Met Val Gln Ala  Lys Ala Asp 
    1610                 1615                 1620             


Leu Gln  Glu Ala Leu Arg Leu  Gly Glu Thr Glu Val  Thr Glu Lys 
    1625                 1630                 1635             


Cys Asn  His Ile Arg Glu Val  Lys Ser Leu Leu Glu  Glu Leu Ser 
    1640                 1645                 1650             


Phe Gln  Lys Gly Glu Leu Asn  Val Gln Ile Ser Glu  Arg Lys Thr 
    1655                 1660                 1665             


Gln Leu  Thr Leu Ile Lys Gln  Glu Ile Glu Lys Glu  Glu Glu Asn 
    1670                 1675                 1680             


Leu Gln  Val Val Leu Arg Gln  Met Ser Lys His Lys  Thr Glu Leu 
    1685                 1690                 1695             


Lys Asn  Ile Leu Asp Met Leu  Gln Leu Glu Asn His  Glu Leu Gln 
    1700                 1705                 1710             


Gly Leu  Lys Leu Gln His Asp  Gln Arg Val Ser Glu  Leu Glu Lys 
    1715                 1720                 1725             


Thr Gln  Val Ala Val Leu Glu  Glu Lys Leu Glu Leu  Glu Asn Leu 
    1730                 1735                 1740             


Gln Gln  Ile Ser Gln Gln Gln  Lys Gly Glu Ile Glu  Trp Gln Lys 
    1745                 1750                 1755             


Gln Leu  Leu Glu Arg Asp Lys  Arg Glu Ile Glu Arg  Met Thr Ala 
    1760                 1765                 1770             


Glu Ser  Arg Ala Leu Gln Ser  Cys Val Glu Cys Leu  Ser Lys Glu 
    1775                 1780                 1785             


Lys Glu  Asp Leu Gln Glu Lys  Cys Asp Ile Trp Glu  Lys Lys Leu 
    1790                 1795                 1800             


Ala Gln  Thr Lys Arg Val Leu  Ala Ala Ala Glu Glu  Asn Ser Lys 
    1805                 1810                 1815             


Met Glu  Gln Ser Asn Leu Glu  Lys Leu Glu Leu Asn  Val Arg Lys 
    1820                 1825                 1830             


Leu Gln  Gln Glu Leu Asp Gln  Leu Asn Arg Asp Lys  Leu Ser Leu 
    1835                 1840                 1845             


His Asn  Asp Ile Ser Ala Met  Gln Gln Gln Leu Gln  Glu Lys Arg 
    1850                 1855                 1860             


Glu Ala  Val Asn Ser Leu Gln  Glu Glu Leu Ala Asn  Val Gln Asp 
    1865                 1870                 1875             


His Leu  Asn Leu Ala Lys Gln  Asp Leu Leu His Thr  Thr Lys His 
    1880                 1885                 1890             


Gln Asp  Val Leu Leu Ser Glu  Gln Thr Arg Leu Gln  Lys Asp Ile 
    1895                 1900                 1905             


Ser Glu  Trp Ala Asn Arg Phe  Glu Asp Cys Gln Lys  Glu Glu Glu 
    1910                 1915                 1920             


Thr Lys  Gln Gln Gln Leu Gln  Val Leu Gln Asn Glu  Ile Glu Glu 
    1925                 1930                 1935             


Asn Lys  Leu Lys Leu Val Gln  Gln Glu Met Met Phe  Gln Arg Leu 
    1940                 1945                 1950             


Gln Lys  Glu Arg Glu Ser Glu  Glu Ser Lys Leu Glu  Thr Ser Lys 
    1955                 1960                 1965             


Val Thr  Leu Lys Glu Gln Gln  His Gln Leu Glu Lys  Glu Leu Thr 
    1970                 1975                 1980             


Asp Gln  Lys Ser Lys Leu Asp  Gln Val Leu Ser Lys  Val Leu Ala 
    1985                 1990                 1995             


Ala Glu  Glu Arg Val Arg Thr  Leu Gln Glu Glu Glu  Arg Trp Cys 
    2000                 2005                 2010             


Glu Ser  Leu Glu Lys Thr Leu  Ser Gln Thr Lys Arg  Gln Leu Ser 
    2015                 2020                 2025             


Glu Arg  Glu Gln Gln Leu Val  Glu Lys Ser Gly Glu  Leu Leu Ala 
    2030                 2035                 2040             


Leu Gln  Lys Glu Ala Asp Ser  Met Arg Ala Asp Phe  Ser Leu Leu 
    2045                 2050                 2055             


Arg Asn  Gln Phe Leu Thr Glu  Arg Lys Lys Ala Glu  Lys Gln Val 
    2060                 2065                 2070             


Ala Ser  Leu Lys Glu Ala Leu  Lys Ile Gln Arg Ser  Gln Leu Glu 
    2075                 2080                 2085             


Lys Asn  Leu Leu Glu Gln Lys  Gln Glu Asn Ser Cys  Ile Gln Lys 
    2090                 2095                 2100             


Glu Met  Ala Thr Ile Glu Leu  Val Ala Gln Asp Asn  His Glu Arg 
    2105                 2110                 2115             


Ala Arg  Arg Leu Met Lys Glu  Leu Asn Gln Met Gln  Tyr Glu Tyr 
    2120                 2125                 2130             


Thr Glu  Leu Lys Lys Gln Met  Ala Asn Gln Lys Asp  Leu Glu Arg 
    2135                 2140                 2145             


Arg Gln  Met Glu Ile Ser Asp  Ala Met Arg Thr Leu  Lys Ser Glu 
    2150                 2155                 2160             


Val Lys  Asp Glu Ile Arg Thr  Ser Leu Lys Asn Leu  Asn Gln Phe 
    2165                 2170                 2175             


Leu Pro  Glu Leu Pro Ala Asp  Leu Glu Ala Ile Leu  Glu Arg Asn 
    2180                 2185                 2190             


Glu Asn  Leu Glu Gly Glu Leu  Glu Ser Leu Lys Glu  Asn Leu Pro 
    2195                 2200                 2205             


Phe Thr  Met Asn Glu Gly Pro  Phe Glu Glu Lys Leu  Asn Phe Ser 
    2210                 2215                 2220             


Gln Val  His Ile Met Asp Glu  His Trp Arg Gly Glu  Ala Leu Arg 
    2225                 2230                 2235             


Glu Lys  Leu Arg His Arg Glu  Asp Arg Leu Lys Ala  Gln Leu Arg 
    2240                 2245                 2250             


His Cys  Met Ser Lys Gln Ala  Glu Val Leu Ile Lys  Gly Lys Arg 
    2255                 2260                 2265             


Gln Thr  Glu Gly Thr Leu His  Ser Leu Arg Arg Gln  Val Asp Ala 
    2270                 2275                 2280             


Leu Gly  Glu Leu Val Thr Ser  Thr Ser Ala Asp Ser  Ala Ser Ser 
    2285                 2290                 2295             


Pro Ser  Leu Ser Gln Leu Glu  Ser Ser Leu Thr Glu  Asp Ser Gln 
    2300                 2305                 2310             


Leu Gly  Gln Asn Gln Glu Lys  Asn Ala Ser Ala Arg  
    2315                 2320                 2325 


<210> 6392
<211> 452
<212> PRT
<213> Homo sapiens

<400> 6392
Met Lys Lys Gly Ser Gln Gln Lys Ile Phe Ser Lys Ala Lys Ile Pro 
1               5                   10                  15      


Ser Ser Ser His Ser Pro Ile Pro Ser Ser Met Ser Asn Met Arg Ser 
            20                  25                  30          


Arg Ser Leu Ser Pro Leu Ile Gly Ser Glu Thr Leu Pro Phe His Ser 
        35                  40                  45              


Gly Gly Gln Trp Cys Glu Gln Val Glu Ile Ala Asp Glu Asn Asn Met 
    50                  55                  60                  


Leu Leu Asp Tyr Gln Asp His Lys Gly Ala Asp Ser His Ala Gly Val 
65                  70                  75                  80  


Arg Tyr Ile Thr Glu Ala Leu Ile Lys Lys Leu Thr Lys Gln Asp Asn 
                85                  90                  95      


Leu Ala Leu Ile Lys Ser Leu Asn Leu Ser Leu Ser Lys Asp Gly Gly 
            100                 105                 110         


Lys Lys Phe Lys Tyr Ile Glu Asn Leu Glu Lys Cys Val Lys Leu Glu 
        115                 120                 125             


Val Leu Asn Leu Ser Tyr Asn Leu Ile Gly Lys Ile Glu Lys Leu Asp 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Leu Asn Leu Ser Tyr Asn Lys Ile Ser 
145                 150                 155                 160 


Lys Ile Glu Gly Ile Glu Asn Met Cys Asn Leu Gln Lys Leu Asn Leu 
                165                 170                 175     


Ala Gly Asn Glu Ile Glu His Ile Pro Val Trp Leu Gly Lys Lys Leu 
            180                 185                 190         


Lys Ser Leu Arg Val Leu Asn Leu Lys Gly Asn Lys Ile Ser Ser Leu 
        195                 200                 205             


Gln Asp Ile Ser Lys Leu Lys Pro Leu Gln Asp Leu Ile Ser Leu Ile 
    210                 215                 220                 


Leu Val Glu Asn Pro Val Val Thr Leu Pro His Tyr Leu Gln Phe Thr 
225                 230                 235                 240 


Ile Phe His Leu Arg Ser Leu Glu Ser Leu Glu Gly Gln Pro Val Thr 
                245                 250                 255     


Thr Gln Asp Arg Gln Glu Ala Phe Glu Arg Phe Ser Leu Glu Glu Val 
            260                 265                 270         


Glu Arg Leu Glu Arg Asp Leu Glu Lys Lys Met Ile Glu Thr Glu Glu 
        275                 280                 285             


Leu Lys Ser Lys Gln Thr Arg Phe Leu Glu Glu Ile Lys Asn Gln Asp 
    290                 295                 300                 


Lys Leu Asn Lys Ser Leu Lys Glu Glu Ala Met Leu Gln Lys Gln Ser 
305                 310                 315                 320 


Cys Glu Glu Leu Lys Ser Asp Leu Asn Thr Lys Asn Glu Leu Leu Lys 
                325                 330                 335     


Gln Lys Thr Ile Glu Leu Thr Arg Ala Cys Gln Lys Gln Tyr Glu Leu 
            340                 345                 350         


Glu Gln Glu Leu Ala Phe Tyr Lys Ile Asp Ala Lys Phe Glu Pro Leu 
        355                 360                 365             


Asn Tyr Tyr Pro Ser Glu Tyr Ala Glu Ile Asp Lys Ala Pro Asp Glu 
    370                 375                 380                 


Ser Pro Tyr Ile Gly Lys Ser Arg Tyr Lys Arg Asn Met Phe Ala Thr 
385                 390                 395                 400 


Glu Ser Tyr Ile Ile Asp Ser Ala Gln Ala Val Gln Ile Lys Lys Met 
                405                 410                 415     


Glu Pro Asp Glu Gln Leu Arg Asn Asp His Met Asn Leu Arg Gly His 
            420                 425                 430         


Thr Pro Leu Asp Thr Gln Leu Glu Asp His Lys Leu Asp Tyr Gln Asn 
        435                 440                 445             


Cys Met Met Lys 
    450         


<210> 6393
<211> 350
<212> PRT
<213> Homo sapiens

<400> 6393
Met Cys Cys Asp Ser Asp Phe Val Ala Arg Asn Lys Ser Gln Asp Ser 
1               5                   10                  15      


Gly Ile Ala Glu Met Glu Glu Leu Pro Val Pro His Asn Ile Lys Ile 
            20                  25                  30          


Ser Asn Ile Thr Cys Asp Ser Phe Lys Ile Ser Trp Glu Met Asp Ser 
        35                  40                  45              


Lys Ser Lys Asp Arg Ile Thr His Tyr Phe Ile Asp Leu Asn Lys Lys 
    50                  55                  60                  


Glu Asn Lys Asn Ser Asn Lys Phe Lys His Lys Asp Val Pro Thr Lys 
65                  70                  75                  80  


Leu Val Ala Lys Ala Val Pro Leu Pro Met Thr Val Arg Gly His Trp 
                85                  90                  95      


Phe Leu Ser Pro Arg Thr Glu Tyr Thr Val Ala Val Gln Thr Ala Ser 
            100                 105                 110         


Lys Gln Val Asp Gly Asp Tyr Val Val Ser Glu Trp Ser Glu Ile Ile 
        115                 120                 125             


Glu Phe Cys Thr Ala Asp Tyr Ser Lys Val His Leu Thr Gln Leu Leu 
    130                 135                 140                 


Glu Lys Ala Glu Val Ile Ala Gly Arg Met Leu Lys Phe Ser Val Phe 
145                 150                 155                 160 


Tyr Arg Asn Gln His Lys Glu Tyr Phe Asp Tyr Val Arg Glu His His 
                165                 170                 175     


Gly Asn Ala Met Gln Pro Ser Val Lys Asp Asn Ser Gly Ser His Gly 
            180                 185                 190         


Ser Pro Ile Ser Gly Lys Leu Glu Gly Ile Phe Phe Ser Cys Ser Thr 
        195                 200                 205             


Glu Phe Asn Thr Gly Lys Pro Pro Gln Asp Ser Pro Tyr Gly Arg Tyr 
    210                 215                 220                 


Arg Phe Glu Ile Ala Ala Glu Lys Leu Phe Asn Pro Asn Thr Asn Leu 
225                 230                 235                 240 


Tyr Phe Gly Asp Phe Tyr Cys Met Tyr Thr Ala Tyr His Tyr Val Ile 
                245                 250                 255     


Leu Val Ile Ala Pro Val Gly Ser Pro Gly Asp Glu Phe Cys Lys Gln 
            260                 265                 270         


Arg Leu Pro Gln Leu Asn Ser Lys Asp Asn Lys Phe Leu Thr Cys Thr 
        275                 280                 285             


Glu Glu Asp Gly Val Leu Val Tyr His His Ala Gln Asp Val Ile Leu 
    290                 295                 300                 


Glu Val Ile Tyr Thr Asp Pro Val Asp Leu Ser Val Gly Thr Val Ala 
305                 310                 315                 320 


Glu Ile Thr Gly His Gln Leu Met Ser Leu Ser Thr Ala Asn Ala Lys 
                325                 330                 335     


Lys Asp Pro Ser Cys Lys Thr Cys Asn Ile Ser Val Gly Arg 
            340                 345                 350 


<210> 6394
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6394
Met Glu Val Pro Arg Leu Asp His Ala Leu Asn Ser Pro Thr Ser Pro 
1               5                   10                  15      


Cys Glu Glu Val Ile Lys Asn Leu Ser Leu Glu Ala Ile Gln Leu Cys 
            20                  25                  30          


Asp Arg Asp Gly Asn Lys Ser Gln Asp Ser Gly Ile Ala Glu Met Glu 
        35                  40                  45              


Glu Leu Pro Val Pro His Asn Ile Lys Ile Ser Asn Ile Thr Cys Asp 
    50                  55                  60                  


Ser Phe Lys Ile Ser Trp Glu Met Asp Ser Lys Ser Lys Asp Arg Ile 
65                  70                  75                  80  


Thr His Tyr Phe Ile Asp Leu Asn Lys Lys Glu Asn Lys Asn Ser Asn 
                85                  90                  95      


Lys Phe Lys His Lys Asp Val Pro Thr Lys Leu Val Ala Lys Ala Val 
            100                 105                 110         


Pro Leu Pro Met Thr Val Arg Gly His Trp Phe Leu Ser Pro Arg Thr 
        115                 120                 125             


Glu Tyr Thr Val Ala Val Gln Thr Ala Ser Lys Gln Val Asp Gly Asp 
    130                 135                 140                 


Tyr Val Val Ser Glu Trp Ser Glu Ile Ile Glu Phe Cys Thr Ala Asp 
145                 150                 155                 160 


Tyr Ser Lys Val His Leu Thr Gln Leu Leu Glu Lys Ala Glu Val Ile 
                165                 170                 175     


Ala Gly Arg Met Leu Lys Phe Ser Val Phe Tyr Arg Asn Gln His Lys 
            180                 185                 190         


Glu Tyr Phe Asp Tyr Val Arg Glu His His Gly Asn Ala Met Gln Pro 
        195                 200                 205             


Ser Val Lys Asp Asn Ser Gly Ser His Gly Ser Pro Ile Ser Gly Lys 
    210                 215                 220                 


Leu Glu Gly Ile Phe Phe Ser Cys Ser Thr Glu Phe Asn Thr Gly Lys 
225                 230                 235                 240 


Pro Pro Gln Asp Ser Pro Tyr Gly Arg Tyr Arg Phe Glu Ile Ala Ala 
                245                 250                 255     


Glu Lys Leu Phe Asn Pro Asn Thr Asn Leu Tyr Phe Gly Asp Phe Tyr 
            260                 265                 270         


Cys Met Tyr Thr Ala Tyr His Tyr Val Ile Leu Val Ile Ala Pro Val 
        275                 280                 285             


Gly Ser Pro Gly Asp Glu Phe Cys Lys Gln Arg Leu Pro Gln Leu Asn 
    290                 295                 300                 


Ser Lys Asp Asn Lys Phe Leu Thr Cys Thr Glu Glu Asp Gly Val Leu 
305                 310                 315                 320 


Val Tyr His His Ala Gln Asp Val Ile Leu Glu Val Ile Tyr Thr Asp 
                325                 330                 335     


Pro Val Asp Leu Ser Val Gly Thr Val Ala Glu Ile Thr Gly His Gln 
            340                 345                 350         


Leu Met Ser Leu Ser Thr Ala Asn Ala Lys Lys Asp Pro Ser Cys Lys 
        355                 360                 365             


Thr Cys Asn Ile Ser Val Gly Arg 
    370                 375     


<210> 6395
<211> 420
<212> PRT
<213> Homo sapiens

<400> 6395
Met Leu Lys Ala Val Ile Leu Ile Gly Gly Pro Gln Lys Gly Thr Arg 
1               5                   10                  15      


Phe Arg Pro Leu Ser Phe Glu Val Pro Lys Pro Leu Phe Pro Val Ala 
            20                  25                  30          


Gly Val Pro Met Ile Gln His His Ile Glu Ala Cys Ala Gln Val Pro 
        35                  40                  45              


Gly Met Gln Glu Ile Leu Leu Ile Gly Phe Tyr Gln Pro Asp Glu Pro 
    50                  55                  60                  


Leu Thr Gln Phe Leu Glu Ala Ala Gln Gln Glu Phe Asn Leu Pro Val 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Phe Ala Pro Leu Gly Thr Gly Gly Gly Leu Tyr 
                85                  90                  95      


His Phe Arg Asp Gln Ile Leu Ala Gly Ser Pro Glu Ala Phe Phe Val 
            100                 105                 110         


Leu Asn Ala Asp Val Cys Ser Asp Phe Pro Leu Ser Ala Met Leu Glu 
        115                 120                 125             


Ala His Arg Arg Gln Arg His Pro Phe Leu Leu Leu Gly Thr Thr Ala 
    130                 135                 140                 


Asn Arg Thr Gln Ser Leu Asn Tyr Gly Cys Ile Val Glu Asn Pro Gln 
145                 150                 155                 160 


Thr His Glu Val Leu His Tyr Val Glu Lys Pro Ser Thr Phe Ile Ser 
                165                 170                 175     


Asp Ile Ile Asn Cys Gly Ile Tyr Leu Phe Ser Pro Glu Ala Leu Lys 
            180                 185                 190         


Pro Leu Arg Asp Val Phe Gln Arg Asn Gln Gln Asp Gly Gln Leu Glu 
        195                 200                 205             


Asp Ser Pro Gly Leu Trp Pro Gly Ala Gly Thr Ile Arg Leu Glu Gln 
    210                 215                 220                 


Asp Val Phe Ser Ala Leu Ala Gly Gln Gly Gln Ile Tyr Val His Leu 
225                 230                 235                 240 


Thr Asp Gly Ile Trp Ser Gln Ile Lys Ser Ala Gly Ser Ala Leu Tyr 
                245                 250                 255     


Ala Ser Arg Leu Tyr Leu Ser Arg Tyr Gln Asp Thr His Pro Glu Arg 
            260                 265                 270         


Leu Ala Lys His Thr Pro Gly Gly Pro Trp Ile Arg Gly Asn Val Tyr 
        275                 280                 285             


Ile His Pro Thr Ala Lys Val Ala Pro Ser Ala Val Leu Gly Pro Asn 
    290                 295                 300                 


Val Ser Ile Gly Lys Gly Val Thr Val Gly Glu Gly Val Arg Leu Arg 
305                 310                 315                 320 


Glu Ser Ile Val Leu His Gly Ala Thr Leu Gln Glu His Thr Cys Val 
                325                 330                 335     


Leu His Ser Ile Val Gly Trp Gly Ser Thr Val Gly Arg Trp Ala Arg 
            340                 345                 350         


Val Glu Gly Thr Pro Ser Asp Pro Asn Pro Asn Asp Pro Arg Ala Arg 
        355                 360                 365             


Met Asp Ser Glu Ser Leu Phe Lys Asp Gly Lys Leu Leu Pro Ala Ile 
    370                 375                 380                 


Thr Ile Leu Gly Cys Arg Val Arg Ile Pro Ala Glu Val Leu Ile Leu 
385                 390                 395                 400 


Asn Ser Ile Val Leu Pro His Lys Glu Leu Ser Arg Ser Phe Thr Asn 
                405                 410                 415     


Gln Ile Ile Leu 
            420 


<210> 6396
<211> 136
<212> PRT
<213> Homo sapiens

<400> 6396
Asp Pro Leu Ser Trp Leu Ser Gly Pro Trp Gly Gln Val Pro Ala Gly 
1               5                   10                  15      


Ile Cys Pro Pro Arg His Arg Gly Trp Tyr His Phe Arg Asp Gln Ile 
            20                  25                  30          


Leu Ala Gly Ser Pro Glu Ala Phe Phe Val Leu Asn Ala Asp Val Cys 
        35                  40                  45              


Ser Asp Phe Pro Leu Ser Ala Met Leu Glu Ala His Arg Arg Gln Arg 
    50                  55                  60                  


His Pro Phe Leu Leu Leu Gly Thr Thr Ala Asn Arg Thr Gln Ser Leu 
65                  70                  75                  80  


Asn Tyr Gly Cys Ile Val Glu Asn Pro Gln Thr His Glu Val Leu His 
                85                  90                  95      


Tyr Val Glu Lys Pro Ser Thr Phe Ile Ser Asp Ile Ile Asn Cys Gly 
            100                 105                 110         


Ile Tyr Leu Phe Ser Pro Glu Ala Leu Lys Pro Leu Arg Asp Val Phe 
        115                 120                 125             


Gln Arg Asn Gln Gln Asp Gly Gln 
    130                 135     


<210> 6397
<211> 454
<212> PRT
<213> Homo sapiens

<400> 6397
Met Glu Arg Lys Asp Phe Glu Thr Trp Leu Asp Asn Ile Ser Val Thr 
1               5                   10                  15      


Phe Leu Ser Leu Thr Asp Leu Gln Lys Asn Glu Thr Leu Asp His Leu 
            20                  25                  30          


Ile Ser Leu Ser Gly Ala Val Gln Leu Arg His Leu Ser Asn Asn Leu 
        35                  40                  45              


Glu Thr Leu Leu Lys Arg Asp Phe Leu Lys Leu Leu Pro Leu Glu Leu 
    50                  55                  60                  


Ser Phe Tyr Leu Leu Lys Trp Leu Asp Pro Gln Thr Leu Leu Thr Cys 
65                  70                  75                  80  


Cys Leu Val Ser Lys Gln Trp Asn Lys Val Ile Ser Ala Cys Thr Glu 
                85                  90                  95      


Val Trp Gln Thr Ala Cys Lys Asn Leu Gly Trp Gln Ile Asp Asp Ser 
            100                 105                 110         


Val Gln Asp Ala Leu His Trp Lys Lys Val Tyr Leu Lys Ala Ile Leu 
        115                 120                 125             


Arg Met Lys Gln Leu Glu Asp His Glu Ala Phe Glu Thr Ser Ser Leu 
    130                 135                 140                 


Ile Gly His Ser Ala Arg Val Tyr Ala Leu Tyr Tyr Lys Asp Gly Leu 
145                 150                 155                 160 


Leu Cys Thr Gly Ser Asp Asp Leu Ser Ala Lys Leu Trp Asp Val Ser 
                165                 170                 175     


Thr Gly Gln Cys Val Tyr Gly Ile Gln Thr His Thr Cys Ala Ala Val 
            180                 185                 190         


Lys Phe Asp Glu Gln Lys Leu Val Thr Gly Ser Phe Asp Asn Thr Val 
        195                 200                 205             


Ala Cys Trp Glu Trp Ser Ser Gly Ala Arg Thr Gln His Phe Arg Gly 
    210                 215                 220                 


His Thr Gly Ala Val Phe Ser Val Asp Tyr Asn Asp Glu Leu Asp Ile 
225                 230                 235                 240 


Leu Val Ser Gly Ser Ala Asp Phe Thr Val Lys Val Trp Ala Leu Ser 
                245                 250                 255     


Ala Gly Thr Cys Leu Asn Thr Leu Thr Gly His Thr Glu Trp Val Thr 
            260                 265                 270         


Lys Val Val Leu Gln Lys Cys Lys Val Lys Ser Leu Leu His Ser Pro 
        275                 280                 285             


Gly Asp Tyr Ile Leu Leu Ser Ala Asp Lys Tyr Glu Ile Lys Ile Trp 
    290                 295                 300                 


Pro Ile Gly Arg Glu Ile Asn Cys Lys Cys Leu Lys Thr Leu Ser Val 
305                 310                 315                 320 


Ser Glu Asp Arg Ser Ile Cys Leu Gln Pro Arg Leu His Phe Asp Gly 
                325                 330                 335     


Lys Tyr Ile Val Cys Ser Ser Ala Leu Gly Leu Tyr Gln Trp Asp Phe 
            340                 345                 350         


Ala Ser Tyr Asp Ile Leu Arg Val Ile Lys Thr Pro Glu Ile Ala Asn 
        355                 360                 365             


Leu Ala Leu Leu Gly Phe Gly Asp Ile Phe Ala Leu Leu Phe Asp Asn 
    370                 375                 380                 


Arg Tyr Leu Tyr Ile Met Asp Leu Arg Thr Glu Ser Leu Ile Ser Arg 
385                 390                 395                 400 


Trp Pro Leu Pro Glu Tyr Arg Lys Ser Lys Arg Gly Ser Ser Phe Leu 
                405                 410                 415     


Ala Gly Glu Ala Ser Trp Leu Asn Gly Leu Asp Gly His Asn Asp Thr 
            420                 425                 430         


Gly Leu Val Phe Ala Thr Ser Met Pro Asp His Ser Ile His Leu Val 
        435                 440                 445             


Leu Trp Lys Glu His Gly 
    450                 


<210> 6398
<211> 123
<212> PRT
<213> Homo sapiens

<400> 6398
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Arg Pro Trp Cys Val Leu Gln Gly Cys Trp 
65                  70                  75                  80  


Ser Thr Thr Cys Trp Arg Cys Lys Phe Ala Met Thr Ser Trp Arg Thr 
                85                  90                  95      


Ala Ala Trp Arg Lys Ile Leu Glu Lys Ala Ser Asp Phe Pro His Leu 
            100                 105                 110         


Pro Thr Ile Ile Thr Gly Lys Thr Val Asn Ser 
        115                 120             


<210> 6399
<211> 277
<212> PRT
<213> Homo sapiens

<400> 6399
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala 
65                  70                  75                  80  


Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp 
                85                  90                  95      


Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile 
            100                 105                 110         


Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg 
        115                 120                 125             


Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met 
    130                 135                 140                 


Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln 
145                 150                 155                 160 


Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu 
                165                 170                 175     


Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Arg Val Phe Gln Lys Leu 
            180                 185                 190         


Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg 
        195                 200                 205             


Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu 
    210                 215                 220                 


Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro 
225                 230                 235                 240 


Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly 
                245                 250                 255     


Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly 
            260                 265                 270         


Asp Val Asn Leu Pro 
        275         


<210> 6400
<211> 570
<212> PRT
<213> Homo sapiens

<400> 6400
Met Ser Ser Ile Gly Glu Gly Ile Asp Phe Ser Gln Glu Arg Gln Lys 
1               5                   10                  15      


Ile Ser Gly Leu Arg Thr Leu Glu Gln Ser Val Gly Glu Trp Leu Glu 
            20                  25                  30          


Ser Ile Gly Leu Gln Gln Tyr Glu Ser Lys Leu Leu Leu Asn Gly Phe 
        35                  40                  45              


Asp Asp Val His Phe Leu Gly Ser Asn Val Met Glu Glu Gln Asp Leu 
    50                  55                  60                  


Arg Asp Ile Gly Ile Ser Asp Pro Gln His Arg Arg Lys Leu Leu Gln 
65                  70                  75                  80  


Ala Ala Arg Ser Leu Pro Lys Val Lys Ala Leu Gly Tyr Asp Gly Asn 
                85                  90                  95      


Ser Pro Pro Ser Val Pro Ser Trp Leu Asp Ser Leu Gly Leu Gln Asp 
            100                 105                 110         


Tyr Val His Ser Phe Leu Ser Ser Gly Tyr Ser Ser Ile Asp Thr Val 
        115                 120                 125             


Lys Asn Leu Trp Glu Leu Glu Leu Val Asn Val Leu Lys Val Gln Leu 
    130                 135                 140                 


Leu Gly His Arg Lys Arg Ile Ile Ala Ser Leu Ala Asp Arg Pro Tyr 
145                 150                 155                 160 


Glu Glu Pro Pro Gln Lys Pro Pro Arg Phe Ser Gln Leu Arg Cys Gln 
                165                 170                 175     


Asp Leu Leu Ser Gln Thr Ser Ser Pro Leu Ser Gln Asn Asp Ser Cys 
            180                 185                 190         


Thr Gly Arg Ser Ala Asp Leu Leu Leu Pro Pro Gly Asp Thr Gly Arg 
        195                 200                 205             


Arg Arg His Asp Ser Leu His Asp Pro Ala Ala Pro Ser Arg Ala Glu 
    210                 215                 220                 


Arg Phe Arg Ile Gln Glu Glu His Arg Glu Ala Lys Leu Thr Leu Arg 
225                 230                 235                 240 


Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln Ser Trp Gln His 
                245                 250                 255     


Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr Glu Ala Asn Tyr 
            260                 265                 270         


Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Thr Glu Ser Thr Gln 
        275                 280                 285             


Asp Ala Cys Ala Lys Met Arg Lys Ser Thr Glu His Met Lys Lys Ile 
    290                 295                 300                 


Pro Thr Ile Ile Leu Ser Ile Thr Tyr Lys Gly Val Lys Phe Ile Asp 
305                 310                 315                 320 


Ala Ser Asn Lys Asn Val Ile Ala Glu His Glu Ile Arg Asn Ile Ser 
                325                 330                 335     


Cys Ala Ala Gln Asp Pro Glu Asp Leu Cys Thr Phe Ala Tyr Ile Thr 
            340                 345                 350         


Lys Asp Leu Gln Thr Ser His His Tyr Cys His Val Phe Ser Thr Val 
        355                 360                 365             


Asp Val Asn Leu Thr Tyr Glu Ile Ile Leu Thr Leu Gly Gln Ala Phe 
    370                 375                 380                 


Glu Val Ala Tyr Gln Leu Ala Leu Gln Ala Gln Lys Ser Arg Ala Thr 
385                 390                 395                 400 


Gly Ala Ser Ala Ala Glu Met Ile Glu Thr Lys Ser Ser Lys Pro Val 
                405                 410                 415     


Pro Lys Pro Arg Val Gly Val Arg Lys Ser Ala Val Pro Leu Pro Pro 
            420                 425                 430         


Asp Ser Arg Cys Cys Tyr Cys His Thr Cys Thr Thr His Arg Pro Ser 
        435                 440                 445             


Tyr Leu Pro Leu Pro Ser Val Ser Pro Gly Val Lys Leu Glu Pro Pro 
    450                 455                 460                 


Asp Met Asp Gln Asp Ala Gln Ser His Ala Ser Val Ser Trp Val Val 
465                 470                 475                 480 


Asp Pro Lys Pro Asp Ser Lys Arg Ser Leu Ser Thr Asn His Thr Arg 
                485                 490                 495     


Leu Glu Leu Val Cys Cys Ser Gln Pro Glu Asn Glu Leu Val Ser Thr 
            500                 505                 510         


Ile Ser Gly Asp Lys Pro Lys Ser Phe Leu Glu Pro Leu Leu Phe Val 
        515                 520                 525             


Met Pro Thr Thr Ala Tyr Asn His Asn Cys Pro Glu Trp Arg Ser Gln 
    530                 535                 540                 


Lys Asp Gly Gly Cys Ser Thr Ser Glu Cys Pro His His Leu Cys Leu 
545                 550                 555                 560 


Glu Lys Pro Gly Val Leu Ser Leu Glu Met 
                565                 570 


<210> 6401
<211> 594
<212> PRT
<213> Homo sapiens

<400> 6401
Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys 
1               5                   10                  15      


Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val 
            20                  25                  30          


Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp 
        35                  40                  45              


Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro 
    50                  55                  60                  


Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly 
65                  70                  75                  80  


Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg 
                85                  90                  95      


Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala 
            100                 105                 110         


Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly 
        115                 120                 125             


Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro 
    130                 135                 140                 


Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr 
145                 150                 155                 160 


Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr 
                165                 170                 175     


Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Arg Arg Lys Leu Leu Pro Gly Arg Ile Gln Leu Trp Gly 
        195                 200                 205             


His Gly Ile Ala Val Asp Trp Ala Glu Pro Glu Val Glu Val Asp Glu 
    210                 215                 220                 


Asp Thr Met Ser Ser Val Lys Ile Leu Tyr Val Arg Asn Leu Met Leu 
225                 230                 235                 240 


Ser Thr Ser Glu Glu Met Ile Glu Lys Glu Phe Asn Asn Ile Lys Pro 
                245                 250                 255     


Gly Ala Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His 
            260                 265                 270         


Phe Ser Asn Arg Glu Asp Ala Val Glu Ala Met Lys Ala Leu Asn Gly 
        275                 280                 285             


Lys Val Leu Asp Gly Ser Pro Ile Glu Val Thr Leu Ala Lys Pro Val 
    290                 295                 300                 


Asp Lys Asp Ser Tyr Val Arg Tyr Thr Arg Gly Thr Gly Gly Arg Gly 
305                 310                 315                 320 


Thr Met Leu Gln Gly Glu Tyr Thr Tyr Ser Leu Gly Gln Val Tyr Asp 
                325                 330                 335     


Pro Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe Tyr Ala Pro Gln Thr 
            340                 345                 350         


Tyr Ala Ala Ile Pro Ser Leu His Phe Pro Ala Thr Lys Gly His Leu 
        355                 360                 365             


Ser Asn Arg Ala Ile Ile Arg Ala Pro Ser Val Arg Glu Ile Tyr Met 
    370                 375                 380                 


Asn Val Pro Val Gly Ala Ala Gly Val Arg Gly Leu Gly Gly Arg Gly 
385                 390                 395                 400 


Tyr Leu Ala Tyr Thr Gly Leu Gly Arg Gly Tyr Gln Val Lys Gly Asp 
                405                 410                 415     


Lys Arg Glu Asp Lys Leu Tyr Asp Ile Leu Pro Gly Met Glu Leu Thr 
            420                 425                 430         


Pro Met Asn Pro Val Thr Leu Lys Pro Gln Gly Ile Lys Leu Ala Pro 
        435                 440                 445             


Gln Ile Leu Glu Glu Ile Cys Gln Lys Asn Asn Trp Gly Gln Pro Val 
    450                 455                 460                 


Tyr Gln Leu His Ser Ala Ile Gly Gln Asp Gln Arg Gln Leu Phe Leu 
465                 470                 475                 480 


Tyr Lys Ile Thr Ile Pro Ala Leu Ala Ser Gln Asn Pro Ala Ile His 
                485                 490                 495     


Pro Phe Thr Pro Pro Lys Leu Ser Ala Phe Val Asp Glu Ala Lys Thr 
            500                 505                 510         


Tyr Ala Ala Glu Tyr Thr Leu Gln Thr Leu Gly Ile Pro Thr Asp Gly 
        515                 520                 525             


Gly Asp Gly Thr Met Ala Thr Ala Ala Ala Ala Ala Thr Ala Phe Pro 
    530                 535                 540                 


Gly Tyr Ala Val Pro Asn Ala Thr Ala Pro Val Ser Ala Ala Gln Leu 
545                 550                 555                 560 


Lys Gln Ala Val Thr Leu Gly Gln Asp Leu Ala Ala Tyr Thr Thr Tyr 
                565                 570                 575     


Glu Val Tyr Pro Thr Phe Ala Val Thr Ala Arg Gly Asp Gly Tyr Gly 
            580                 585                 590         


Thr Phe 
        


<210> 6402
<211> 594
<212> PRT
<213> Homo sapiens

<400> 6402
Met Glu Ala Val Cys Leu Gly Thr Cys Pro Glu Pro Glu Ala Ser Met 
1               5                   10                  15      


Ser Thr Ala Ile Pro Gly Leu Lys Lys Gly Asn Asn Ala Leu Gln Ser 
            20                  25                  30          


Ile Ile Leu Gln Thr Leu Leu Glu Lys Glu Asn Gly Gln Arg Lys Tyr 
        35                  40                  45              


Gly Gly Pro Pro Pro Gly Trp Asp Ala Ala Pro Pro Glu Arg Gly Cys 
    50                  55                  60                  


Glu Ile Phe Ile Gly Lys Leu Pro Arg Asp Leu Phe Glu Asp Glu Leu 
65                  70                  75                  80  


Ile Pro Leu Cys Glu Lys Ile Gly Lys Ile Tyr Glu Met Arg Met Met 
                85                  90                  95      


Met Asp Phe Asn Gly Asn Asn Arg Gly Tyr Ala Phe Val Thr Phe Ser 
            100                 105                 110         


Asn Lys Val Glu Ala Lys Asn Ala Ile Lys Gln Leu Asn Asn Tyr Glu 
        115                 120                 125             


Ile Arg Asn Gly Arg Leu Leu Gly Val Cys Ala Ser Val Asp Asn Cys 
    130                 135                 140                 


Arg Leu Phe Val Gly Gly Ile Pro Lys Thr Lys Lys Arg Glu Glu Ile 
145                 150                 155                 160 


Leu Ser Glu Met Lys Lys Val Thr Glu Gly Val Val Asp Val Ile Val 
                165                 170                 175     


Tyr Pro Ser Ala Ala Asp Lys Thr Lys Asn Arg Gly Phe Ala Phe Val 
            180                 185                 190         


Glu Tyr Glu Ser His Arg Ala Ala Ala Met Ala Arg Arg Lys Leu Leu 
        195                 200                 205             


Pro Gly Arg Ile Gln Leu Trp Gly His Gly Ile Ala Val Asp Trp Ala 
    210                 215                 220                 


Glu Pro Glu Val Glu Val Asp Glu Asp Thr Met Ser Ser Val Lys Ile 
225                 230                 235                 240 


Leu Tyr Val Arg Asn Leu Met Leu Ser Thr Ser Glu Glu Met Ile Glu 
                245                 250                 255     


Lys Glu Phe Asn Asn Ile Lys Pro Gly Ala Val Glu Arg Val Lys Lys 
            260                 265                 270         


Ile Arg Asp Tyr Ala Phe Val His Phe Ser Asn Arg Glu Asp Ala Val 
        275                 280                 285             


Glu Ala Met Lys Ala Leu Asn Gly Lys Val Leu Asp Gly Ser Pro Ile 
    290                 295                 300                 


Glu Val Thr Leu Ala Lys Pro Val Asp Lys Asp Ser Tyr Val Arg Tyr 
305                 310                 315                 320 


Thr Arg Gly Thr Gly Gly Arg Gly Thr Met Leu Gln Gly Glu Tyr Thr 
                325                 330                 335     


Tyr Ser Leu Gly Gln Val Tyr Asp Pro Thr Thr Thr Tyr Leu Gly Ala 
            340                 345                 350         


Pro Val Phe Tyr Ala Pro Gln Thr Tyr Ala Ala Ile Pro Ser Leu His 
        355                 360                 365             


Phe Pro Ala Thr Lys Gly His Leu Ser Asn Arg Ala Ile Ile Arg Ala 
    370                 375                 380                 


Pro Ser Val Arg Gly Ala Ala Gly Val Arg Gly Leu Gly Gly Arg Gly 
385                 390                 395                 400 


Tyr Leu Ala Tyr Thr Gly Leu Gly Arg Gly Tyr Gln Val Lys Gly Asp 
                405                 410                 415     


Lys Arg Glu Asp Lys Leu Tyr Asp Ile Leu Pro Gly Met Glu Leu Thr 
            420                 425                 430         


Pro Met Asn Pro Val Thr Leu Lys Pro Gln Gly Ile Lys Leu Ala Pro 
        435                 440                 445             


Gln Ile Leu Glu Glu Ile Cys Gln Lys Asn Asn Trp Gly Gln Pro Val 
    450                 455                 460                 


Tyr Gln Leu His Ser Ala Ile Gly Gln Asp Gln Arg Gln Leu Phe Leu 
465                 470                 475                 480 


Tyr Lys Ile Thr Ile Pro Ala Leu Ala Ser Gln Asn Pro Ala Ile His 
                485                 490                 495     


Pro Phe Thr Pro Pro Lys Leu Ser Ala Phe Val Asp Glu Ala Lys Thr 
            500                 505                 510         


Tyr Ala Ala Glu Tyr Thr Leu Gln Thr Leu Gly Ile Pro Thr Asp Gly 
        515                 520                 525             


Gly Asp Gly Thr Met Ala Thr Ala Ala Ala Ala Ala Thr Ala Phe Pro 
    530                 535                 540                 


Gly Tyr Ala Val Pro Asn Ala Thr Ala Pro Val Ser Ala Ala Gln Leu 
545                 550                 555                 560 


Lys Gln Ala Val Thr Leu Gly Gln Asp Leu Ala Ala Tyr Thr Thr Tyr 
                565                 570                 575     


Glu Val Tyr Pro Thr Phe Ala Val Thr Ala Arg Gly Asp Gly Tyr Gly 
            580                 585                 590         


Thr Phe 
        


<210> 6403
<211> 586
<212> PRT
<213> Homo sapiens

<400> 6403
Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys 
1               5                   10                  15      


Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val 
            20                  25                  30          


Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp 
        35                  40                  45              


Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro 
    50                  55                  60                  


Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly 
65                  70                  75                  80  


Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg 
                85                  90                  95      


Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala 
            100                 105                 110         


Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly 
        115                 120                 125             


Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro 
    130                 135                 140                 


Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr 
145                 150                 155                 160 


Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr 
                165                 170                 175     


Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Arg Arg Lys Leu Leu Pro Gly Arg Ile Gln Leu Trp Gly 
        195                 200                 205             


His Gly Ile Ala Val Asp Trp Ala Glu Pro Glu Val Glu Val Asp Glu 
    210                 215                 220                 


Asp Thr Met Ser Ser Val Lys Ile Leu Tyr Val Arg Asn Leu Met Leu 
225                 230                 235                 240 


Ser Thr Ser Glu Glu Met Ile Glu Lys Glu Phe Asn Asn Ile Lys Pro 
                245                 250                 255     


Gly Ala Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His 
            260                 265                 270         


Phe Ser Asn Arg Glu Asp Ala Val Glu Ala Met Lys Ala Leu Asn Gly 
        275                 280                 285             


Lys Val Leu Asp Gly Ser Pro Ile Glu Val Thr Leu Ala Lys Pro Val 
    290                 295                 300                 


Asp Lys Asp Ser Tyr Val Arg Tyr Thr Arg Gly Thr Gly Gly Arg Gly 
305                 310                 315                 320 


Thr Met Leu Gln Gly Glu Tyr Thr Tyr Ser Leu Gly Gln Val Tyr Asp 
                325                 330                 335     


Pro Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe Tyr Ala Pro Gln Thr 
            340                 345                 350         


Tyr Ala Ala Ile Pro Ser Leu His Phe Pro Ala Thr Lys Gly His Leu 
        355                 360                 365             


Ser Asn Arg Ala Ile Ile Arg Ala Pro Ser Val Arg Gly Ala Ala Gly 
    370                 375                 380                 


Val Arg Gly Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu Gly 
385                 390                 395                 400 


Arg Gly Tyr Gln Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr Asp 
                405                 410                 415     


Ile Leu Pro Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu Lys 
            420                 425                 430         


Pro Gln Gly Ile Lys Leu Ala Pro Gln Ile Leu Glu Glu Ile Cys Gln 
        435                 440                 445             


Lys Asn Asn Trp Gly Gln Pro Val Tyr Gln Leu His Ser Ala Ile Gly 
    450                 455                 460                 


Gln Asp Gln Arg Gln Leu Phe Leu Tyr Lys Ile Thr Ile Pro Ala Leu 
465                 470                 475                 480 


Ala Ser Gln Asn Pro Ala Ile His Pro Phe Thr Pro Pro Lys Leu Ser 
                485                 490                 495     


Ala Phe Val Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu Gln 
            500                 505                 510         


Thr Leu Gly Ile Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr Ala 
        515                 520                 525             


Ala Ala Ala Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala Thr 
    530                 535                 540                 


Ala Pro Val Ser Ala Ala Gln Leu Lys Gln Ala Val Thr Leu Gly Gln 
545                 550                 555                 560 


Asp Leu Ala Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala Val 
                565                 570                 575     


Thr Ala Arg Gly Asp Gly Tyr Gly Thr Phe 
            580                 585     


<210> 6404
<211> 586
<212> PRT
<213> Homo sapiens

<400> 6404
Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys 
1               5                   10                  15      


Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val 
            20                  25                  30          


Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp 
        35                  40                  45              


Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro 
    50                  55                  60                  


Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly 
65                  70                  75                  80  


Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg 
                85                  90                  95      


Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala 
            100                 105                 110         


Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly 
        115                 120                 125             


Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro 
    130                 135                 140                 


Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr 
145                 150                 155                 160 


Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr 
                165                 170                 175     


Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Arg Arg Lys Leu Leu Pro Gly Arg Ile Gln Leu Trp Gly 
        195                 200                 205             


His Gly Ile Ala Val Asp Trp Ala Glu Pro Glu Val Glu Val Asp Glu 
    210                 215                 220                 


Asp Thr Met Ser Ser Val Lys Ile Leu Tyr Val Arg Asn Leu Met Leu 
225                 230                 235                 240 


Ser Thr Ser Glu Glu Met Ile Glu Lys Glu Phe Asn Asn Ile Lys Pro 
                245                 250                 255     


Gly Ala Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His 
            260                 265                 270         


Phe Ser Asn Arg Glu Asp Ala Val Glu Ala Met Lys Ala Leu Asn Gly 
        275                 280                 285             


Lys Val Leu Asp Gly Ser Pro Ile Glu Val Thr Leu Ala Lys Pro Val 
    290                 295                 300                 


Asp Lys Asp Ser Tyr Val Arg Tyr Thr Arg Gly Thr Gly Gly Arg Gly 
305                 310                 315                 320 


Thr Met Leu Gln Gly Glu Tyr Thr Tyr Ser Leu Gly Gln Val Tyr Asp 
                325                 330                 335     


Pro Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe Tyr Ala Pro Gln Thr 
            340                 345                 350         


Tyr Ala Ala Ile Pro Ser Leu His Phe Pro Ala Thr Lys Gly His Leu 
        355                 360                 365             


Ser Asn Arg Ala Ile Ile Arg Ala Pro Ser Val Arg Gly Ala Ala Gly 
    370                 375                 380                 


Val Arg Gly Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu Gly 
385                 390                 395                 400 


Arg Gly Tyr Gln Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr Asp 
                405                 410                 415     


Ile Leu Pro Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu Lys 
            420                 425                 430         


Pro Gln Gly Ile Lys Leu Ala Pro Gln Ile Leu Glu Glu Ile Cys Gln 
        435                 440                 445             


Lys Asn Asn Trp Gly Gln Pro Val Tyr Gln Leu His Ser Ala Ile Gly 
    450                 455                 460                 


Gln Asp Gln Arg Gln Leu Phe Leu Tyr Lys Ile Thr Ile Pro Ala Leu 
465                 470                 475                 480 


Ala Ser Gln Asn Pro Ala Ile His Pro Phe Thr Pro Pro Lys Leu Ser 
                485                 490                 495     


Ala Phe Val Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu Gln 
            500                 505                 510         


Thr Leu Gly Ile Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr Ala 
        515                 520                 525             


Ala Ala Ala Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala Thr 
    530                 535                 540                 


Ala Pro Val Ser Ala Ala Gln Leu Lys Gln Ala Val Thr Leu Gly Gln 
545                 550                 555                 560 


Asp Leu Ala Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala Val 
                565                 570                 575     


Thr Ala Arg Gly Asp Gly Tyr Gly Thr Phe 
            580                 585     


<210> 6405
<211> 513
<212> PRT
<213> Homo sapiens

<400> 6405
Met Gln Arg Thr Phe Ala Trp Leu Leu Asp Arg Val Gln His Leu Gly 
1               5                   10                  15      


Ala Pro Val Thr Leu Arg Ala Ser Tyr Leu Glu Ile Tyr Asn Glu Gln 
            20                  25                  30          


Val Arg Asp Leu Leu Ser Leu Gly Ser Pro Arg Pro Leu Pro Val Arg 
        35                  40                  45              


Trp Asn Lys Thr Arg Gly Phe Tyr Val Glu Gln Leu Arg Val Val Glu 
    50                  55                  60                  


Phe Gly Ser Leu Glu Ala Leu Met Glu Leu Leu Gln Thr Gly Leu Ser 
65                  70                  75                  80  


Arg Arg Arg Asn Ser Ala His Thr Leu Asn Gln Ala Ser Ser Arg Ser 
                85                  90                  95      


His Ala Leu Leu Thr Leu Tyr Ile Ser Arg Gln Thr Ala Gln Gln Met 
            100                 105                 110         


Pro Ser Val Asp Pro Gly Glu Pro Pro Val Gly Gly Lys Leu Cys Phe 
        115                 120                 125             


Val Asp Leu Ala Gly Ser Glu Lys Val Ala Ala Thr Gly Ser Arg Gly 
    130                 135                 140                 


Glu Leu Met Leu Glu Ala Asn Ser Ile Asn Arg Ser Leu Leu Ala Leu 
145                 150                 155                 160 


Gly His Cys Ile Ser Leu Leu Leu Asp Pro Gln Arg Lys Gln Ser His 
                165                 170                 175     


Ile Pro Phe Arg Asp Ser Lys Leu Thr Lys Leu Leu Ala Asp Ser Leu 
            180                 185                 190         


Gly Gly Arg Gly Val Thr Leu Met Val Ala Cys Val Ser Pro Ser Ala 
        195                 200                 205             


Gln Cys Leu Pro Glu Thr Leu Ser Thr Leu Arg Tyr Ala Ser Arg Ala 
    210                 215                 220                 


Gln Arg Val Thr Thr Arg Pro Gln Ala Pro Lys Ser Pro Val Ala Lys 
225                 230                 235                 240 


Gln Pro Gln Arg Leu Glu Thr Glu Met Leu Gln Leu Gln Glu Glu Asn 
                245                 250                 255     


Arg Arg Leu Gln Phe Gln Leu Asp Gln Met Asp Cys Lys Ala Ser Gly 
            260                 265                 270         


Leu Ser Gly Ala Arg Val Ala Trp Ala Gln Arg Asn Leu Tyr Gly Met 
        275                 280                 285             


Leu Gln Glu Phe Met Leu Glu Asn Glu Arg Leu Arg Lys Glu Lys Ser 
    290                 295                 300                 


Gln Leu Gln Asn Ser Arg Asp Leu Ala Gln Asn Glu Gln Arg Ile Leu 
305                 310                 315                 320 


Ala Gln Gln Val His Ala Leu Glu Arg Arg Leu Leu Ser Ala Cys Tyr 
                325                 330                 335     


His His Gln Gln Gly Pro Gly Leu Thr Pro Pro Cys Pro Cys Leu Met 
            340                 345                 350         


Ala Pro Ala Pro Pro Cys His Ala Leu Pro Pro Leu Tyr Ser Cys Pro 
        355                 360                 365             


Cys Cys His Ile Cys Pro Leu Cys Arg Val Pro Leu Ala His Trp Ala 
    370                 375                 380                 


Cys Leu Pro Gly Glu His His Leu Pro Gln Val Leu Asp Pro Glu Ala 
385                 390                 395                 400 


Ser Gly Gly Arg Pro Pro Ser Ala Arg Pro Pro Pro Trp Ala Pro Pro 
                405                 410                 415     


Cys Ser Pro Gly Ser Ala Lys Cys Pro Arg Glu Arg Ser His Ser Asp 
            420                 425                 430         


Trp Thr Gln Thr Arg Val Leu Ala Glu Met Leu Thr Glu Glu Glu Val 
        435                 440                 445             


Val Pro Ser Ala Pro Pro Leu Pro Val Arg Pro Pro Lys Thr Ser Pro 
    450                 455                 460                 


Gly Leu Arg Gly Gly Ala Gly Val Pro Asn Leu Ala Gln Arg Leu Glu 
465                 470                 475                 480 


Ala Leu Arg Asp Gln Ile Gly Ser Ser Leu Arg Arg Gly Arg Ser Gln 
                485                 490                 495     


Pro Pro Cys Ser Glu Gly Ala Arg Ser Pro Gly Gln Val Leu Pro Pro 
            500                 505                 510         


His 
    


<210> 6406
<211> 261
<212> PRT
<213> Homo sapiens

<400> 6406
Met Val Lys Gly Glu Lys Gly Pro Lys Gly Lys Lys Ile Thr Leu Lys 
1               5                   10                  15      


Val Ala Arg Asn Cys Ile Lys Ile Thr Phe Asp Gly Lys Lys Arg Leu 
            20                  25                  30          


Asp Leu Ser Lys Met Gly Ile Thr Thr Phe Pro Lys Cys Ile Leu Arg 
        35                  40                  45              


Leu Ser Asp Met Asp Glu Leu Asp Leu Ser Arg Asn Leu Ile Arg Lys 
    50                  55                  60                  


Ile Pro Asp Ser Ile Ser Lys Phe Gln Asn Leu Arg Trp Leu Asp Leu 
65                  70                  75                  80  


His Ser Asn Tyr Ile Asp Lys Leu Pro Glu Ser Ile Gly Gln Met Thr 
                85                  90                  95      


Ser Leu Leu Tyr Leu Asn Val Ser Asn Asn Arg Leu Thr Ser Asn Gly 
            100                 105                 110         


Leu Pro Val Glu Leu Lys Gln Leu Lys Asn Ile Arg Ala Val Asn Leu 
        115                 120                 125             


Gly Leu Asn His Leu Asp Ser Val Pro Thr Thr Leu Gly Ala Leu Lys 
    130                 135                 140                 


Glu Leu His Glu Val Gly Leu His Asp Asn Leu Leu Asn Asn Ile Pro 
145                 150                 155                 160 


Val Ser Ile Ser Lys Leu Pro Lys Leu Lys Lys Leu Asn Ile Lys Arg 
                165                 170                 175     


Asn Pro Phe Pro Lys Pro Gly Glu Ser Glu Ile Phe Ile Asp Ser Ile 
            180                 185                 190         


Arg Arg Leu Glu Asn Leu Tyr Val Val Glu Glu Lys Asp Leu Cys Ala 
        195                 200                 205             


Ala Cys Leu Arg Lys Cys Gln Asn Ala Arg Asp Asn Leu Asn Arg Ile 
    210                 215                 220                 


Lys Asn Met Ala Thr Thr Thr Pro Arg Lys Thr Ile Phe Pro Asn Leu 
225                 230                 235                 240 


Ile Ser Pro Asn Ser Met Ala Lys Asp Ser Trp Glu Asp Trp Arg Ile 
                245                 250                 255     


Arg Leu Thr Ser Ser 
            260     


<210> 6407
<211> 589
<212> PRT
<213> Homo sapiens

<400> 6407
Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln Ala Ile Arg 
1               5                   10                  15      


Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Thr Ala Arg Arg Ser His 
            20                  25                  30          


Ala His Pro Leu Glu Pro Leu Pro Pro Gly Ile Phe Gly Gln Arg Leu 
        35                  40                  45              


Glu Glu Thr Val His His Glu Arg Lys Tyr Gly Pro Arg Leu Ala Pro 
    50                  55                  60                  


Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg Gly Leu Thr 
65                  70                  75                  80  


Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu Val Arg Asp 
                85                  90                  95      


Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe Asp Ser Thr 
            100                 105                 110         


Thr Asp Val His Thr Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu 
        115                 120                 125             


Leu Pro Glu Pro Val Val Pro Phe Ala Arg Tyr Glu Asp Phe Leu Ser 
    130                 135                 140                 


Cys Ala Gln Leu Leu Thr Lys Asp Glu Gly Glu Gly Thr Leu Glu Leu 
145                 150                 155                 160 


Ala Lys Gln Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn Leu Leu Arg 
                165                 170                 175     


Tyr Ile Cys Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn 
            180                 185                 190         


Lys Met Ser Val Gln Asn Leu Ala Thr Val Phe Gly Pro Asn Ile Leu 
        195                 200                 205             


Arg Pro Gln Val Glu Asp Pro Val Thr Ile Met Glu Gly Thr Ser Leu 
    210                 215                 220                 


Val Gln His Leu Met Thr Val Leu Ile Arg Lys His Ser Gln Leu Phe 
225                 230                 235                 240 


Thr Ala Pro Val Pro Glu Gly Pro Thr Ser Pro Arg Gly Gly Leu Gln 
                245                 250                 255     


Cys Ala Val Gly Trp Gly Ser Glu Glu Val Thr Arg Asp Ser Gln Gly 
            260                 265                 270         


Glu Pro Gly Gly Pro Gly Leu Pro Ala His Arg Thr Ser Ser Leu Asp 
        275                 280                 285             


Gly Ala Ala Val Ala Val Leu Ser Arg Thr Ala Pro Thr Gly Pro Gly 
    290                 295                 300                 


Ser Arg Cys Ser Pro Gly Lys Lys Val Gln Thr Leu Pro Ser Trp Lys 
305                 310                 315                 320 


Ser Ser Phe Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly 
                325                 330                 335     


Gly Ser Ser Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu 
            340                 345                 350         


Met Asn Gly Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly 
        355                 360                 365             


Asp Arg Leu Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Thr Tyr Asp 
    370                 375                 380                 


Asn Val Pro Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser 
385                 390                 395                 400 


Met Ala Trp Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser 
                405                 410                 415     


Leu Ser Ser Cys Thr Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser 
            420                 425                 430         


Ser Leu His Thr Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser 
        435                 440                 445             


Ser Glu Asp Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala 
    450                 455                 460                 


Gly Ala Gly Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Thr 
465                 470                 475                 480 


Arg Glu His Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Thr Glu 
                485                 490                 495     


Leu Arg Ala Glu Leu Cys Arg Gln Arg Thr Glu Tyr Glu Arg Ser Val 
            500                 505                 510         


Lys Arg Ile Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg 
        515                 520                 525             


Leu Glu Glu Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu 
    530                 535                 540                 


Ile Lys Leu Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg 
545                 550                 555                 560 


Asn Gln Leu Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Thr Leu Gly 
                565                 570                 575     


Ser Leu Thr Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
            580                 585                 


<210> 6408
<211> 402
<212> PRT
<213> Homo sapiens

<400> 6408
Met Ser Ala Glu Gly Ala Glu Pro Gly Pro Gly Ser Gly Ser Gly Pro 
1               5                   10                  15      


Gly Pro Gly Pro Leu Cys Pro Glu His Gly Gln Ala Leu Ser Trp Phe 
            20                  25                  30          


Cys Gly Ser Glu Arg Arg Pro Val Cys Ala Ala Cys Ala Gly Leu Gly 
        35                  40                  45              


Gly Arg Cys Arg Gly His Arg Ile Arg Arg Ala Glu Glu Arg Ala Glu 
    50                  55                  60                  


Glu Leu Arg Asn Lys Ile Val Asp Gln Cys Glu Arg Leu Gln Leu Gln 
65                  70                  75                  80  


Ser Ala Ala Ile Thr Lys Tyr Val Ala Asp Val Leu Pro Gly Lys Asn 
                85                  90                  95      


Gln Arg Ala Val Ser Met Ala Ser Ala Ala Arg Glu Leu Val Ile Gln 
            100                 105                 110         


Arg Leu Ser Leu Val Arg Ser Leu Cys Glu Ser Glu Glu Gln Arg Leu 
        115                 120                 125             


Leu Glu Gln Val His Gly Glu Glu Glu Arg Ala His Gln Ser Ile Leu 
    130                 135                 140                 


Thr Gln Arg Val His Trp Ala Glu Ala Leu Gln Lys Leu Asp Thr Ile 
145                 150                 155                 160 


Arg Thr Gly Leu Val Gly Met Leu Thr His Leu Asp Asp Leu Gln Leu 
                165                 170                 175     


Ile Gln Lys Glu Gln Glu Ile Phe Glu Arg Thr Glu Glu Ala Glu Gly 
            180                 185                 190         


Ile Leu Asp Pro Gln Glu Ser Glu Met Leu Asn Phe Asn Glu Lys Cys 
        195                 200                 205             


Thr Arg Ser Pro Leu Leu Thr Gln Leu Trp Ala Thr Ala Val Leu Gly 
    210                 215                 220                 


Ser Leu Ser Gly Thr Glu Asp Ile Arg Ile Asp Glu Arg Thr Val Ser 
225                 230                 235                 240 


Pro Phe Leu Gln Leu Ser Asp Asp Arg Lys Thr Leu Thr Phe Ser Thr 
                245                 250                 255     


Lys Lys Ser Lys Ala Cys Ala Asp Gly Pro Glu Arg Phe Asp His Trp 
            260                 265                 270         


Pro Asn Ala Leu Ala Ala Thr Ser Phe Gln Asn Gly Leu His Ala Trp 
        275                 280                 285             


Met Val Asn Val Gln Asn Ser Cys Ala Tyr Lys Val Gly Val Ala Ser 
    290                 295                 300                 


Gly His Leu Pro Arg Lys Gly Ser Gly Ser Asp Cys Arg Leu Gly His 
305                 310                 315                 320 


Asn Ala Phe Ser Trp Val Phe Ser Arg Tyr Asp Gln Glu Phe Arg Phe 
                325                 330                 335     


Ser His Asn Gly Gln His Glu Pro Leu Gly Leu Leu Arg Gly Pro Ala 
            340                 345                 350         


Gln Leu Gly Val Val Leu Asp Leu Gln Val Gln Glu Leu Leu Phe Tyr 
        355                 360                 365             


Glu Pro Ala Ser Gly Thr Val Leu Cys Ala His His Val Ser Phe Pro 
    370                 375                 380                 


Gly Pro Leu Phe Pro Val Phe Ala Val Ala Asp Gln Thr Ile Ser Ile 
385                 390                 395                 400 


Val Arg 
        


<210> 6409
<211> 85
<212> PRT
<213> Homo sapiens

<400> 6409
Met Leu Arg Arg Lys Pro Thr Arg Leu Glu Leu Lys Leu Asp Asp Ile 
1               5                   10                  15      


Glu Glu Phe Glu Asn Ile Arg Lys Asp Leu Glu Thr Arg Lys Lys Gln 
            20                  25                  30          


Lys Glu Asp Val Glu Val Val Gly Gly Ser Asp Gly Glu Gly Ala Ile 
        35                  40                  45              


Gly Leu Ser Ser Asp Pro Lys Ser Arg Glu Gln Met Ile Asn Asp Arg 
    50                  55                  60                  


Ile Gly Tyr Lys Pro Gln Pro Lys Pro Asn Asn Arg Ser Ser Gln Phe 
65                  70                  75                  80  


Gly Ser Leu Glu Phe 
                85  


<210> 6410
<211> 247
<212> PRT
<213> Homo sapiens

<400> 6410
Met Leu Ser Asp Gly Cys Gly Ser Glu Glu Lys Ile Ser Val Pro Ser 
1               5                   10                  15      


Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser Arg Gln Val Pro Ala Ser 
            20                  25                  30          


His Asp Ser Glu Leu Met Ala Phe Met Thr Arg Lys Leu Trp Asp Leu 
        35                  40                  45              


Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile Leu Ser Lys Asp Gln 
    50                  55                  60                  


Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr Leu Arg Pro His Pro 
65                  70                  75                  80  


Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu Glu Thr Met Cys Val 
                85                  90                  95      


Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg Phe Leu Ser Asp Tyr 
            100                 105                 110         


Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln Glu Asp Ser Glu Ser 
        115                 120                 125             


Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp Met Thr Ala Lys Lys 
    130                 135                 140                 


Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro Glu Val Asp Phe Asp 
145                 150                 155                 160 


Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu Leu Val Val Glu Gly 
                165                 170                 175     


Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala Arg Leu Arg Thr Leu 
            180                 185                 190         


Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly Ile Met Met Phe Asp 
        195                 200                 205             


Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr Gln Arg Cys Leu Arg 
    210                 215                 220                 


Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu Gln Arg Leu Tyr Pro 
225                 230                 235                 240 


Asn Gly Val Pro Phe Lys Val 
                245         


<210> 6411
<211> 487
<212> PRT
<213> Homo sapiens

<400> 6411
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro 
145                 150                 155                 160 


Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu 
                165                 170                 175     


Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala 
            180                 185                 190         


Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly 
        195                 200                 205             


Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr 
    210                 215                 220                 


Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu 
225                 230                 235                 240 


Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg 
                245                 250                 255     


Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly 
            260                 265                 270         


Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val Glu 
        275                 280                 285             


Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu 
    290                 295                 300                 


Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro 
305                 310                 315                 320 


Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln 
                325                 330                 335     


Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser 
            340                 345                 350         


Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile 
        355                 360                 365             


Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp 
    370                 375                 380                 


Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met 
385                 390                 395                 400 


Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr 
                405                 410                 415     


Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala 
            420                 425                 430         


Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe 
        435                 440                 445             


Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro 
    450                 455                 460                 


Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro 
465                 470                 475                 480 


Gly Pro Ser Pro Ser Pro Gln 
                485         


<210> 6412
<211> 339
<212> PRT
<213> Homo sapiens

<400> 6412
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr Ile 
        115                 120                 125             


Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe Tyr 
    130                 135                 140                 


Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp Gln 
145                 150                 155                 160 


Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg Glu 
                165                 170                 175     


Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn Tyr 
        195                 200                 205             


Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu Lys 
    210                 215                 220                 


Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys Trp 
225                 230                 235                 240 


Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile 
                245                 250                 255     


Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His Cys 
            260                 265                 270         


Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val Val 
        275                 280                 285             


Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile Val 
    290                 295                 300                 


Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln 
305                 310                 315                 320 


Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu 
                325                 330                 335     


Thr Leu Asp 
            


<210> 6413
<211> 520
<212> PRT
<213> Homo sapiens

<400> 6413
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr 
65                  70                  75                  80  


Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu 
                85                  90                  95      


Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln 
            100                 105                 110         


Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu 
        115                 120                 125             


Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu 
    130                 135                 140                 


Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp 
145                 150                 155                 160 


Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp 
                165                 170                 175     


Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro 
            180                 185                 190         


Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser 
        195                 200                 205             


Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly 
    210                 215                 220                 


Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn 
225                 230                 235                 240 


Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser 
                245                 250                 255     


Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu 
            260                 265                 270         


Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu 
        275                 280                 285             


Arg Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu 
    290                 295                 300                 


Gly Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val 
305                 310                 315                 320 


Glu Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg 
                325                 330                 335     


Leu Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly 
            340                 345                 350         


Pro Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile 
        355                 360                 365             


Gln Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg 
    370                 375                 380                 


Ser Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg 
385                 390                 395                 400 


Ile Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro 
                405                 410                 415     


Asp Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val 
            420                 425                 430         


Met Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu 
        435                 440                 445             


Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys 
    450                 455                 460                 


Ala Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys 
465                 470                 475                 480 


Phe Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
                485                 490                 495     


Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys 
            500                 505                 510         


Pro Gly Pro Ser Pro Ser Pro Gln 
        515                 520 


<210> 6414
<211> 520
<212> PRT
<213> Homo sapiens

<400> 6414
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr 
65                  70                  75                  80  


Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu 
                85                  90                  95      


Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln 
            100                 105                 110         


Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu 
        115                 120                 125             


Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu 
    130                 135                 140                 


Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp 
145                 150                 155                 160 


Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp 
                165                 170                 175     


Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro 
            180                 185                 190         


Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser 
        195                 200                 205             


Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly 
    210                 215                 220                 


Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn 
225                 230                 235                 240 


Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser 
                245                 250                 255     


Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu 
            260                 265                 270         


Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu 
        275                 280                 285             


Arg Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu 
    290                 295                 300                 


Gly Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val 
305                 310                 315                 320 


Glu Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg 
                325                 330                 335     


Leu Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly 
            340                 345                 350         


Pro Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile 
        355                 360                 365             


Gln Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg 
    370                 375                 380                 


Ser Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg 
385                 390                 395                 400 


Ile Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro 
                405                 410                 415     


Asp Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val 
            420                 425                 430         


Met Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu 
        435                 440                 445             


Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys 
    450                 455                 460                 


Ala Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys 
465                 470                 475                 480 


Phe Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
                485                 490                 495     


Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys 
            500                 505                 510         


Pro Gly Pro Ser Pro Ser Pro Gln 
        515                 520 


<210> 6415
<211> 277
<212> PRT
<213> Homo sapiens

<400> 6415
Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr Gln Arg 
1               5                   10                  15      


Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu Gln Arg 
            20                  25                  30          


Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg Asn Gln 
        35                  40                  45              


Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly Arg Val 
    50                  55                  60                  


Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val Glu Glu His 
65                  70                  75                  80  


Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu Pro Lys 
                85                  90                  95      


Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro Ile Arg 
            100                 105                 110         


Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln Glu Ile 
        115                 120                 125             


Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser Gln Glu 
    130                 135                 140                 


Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile Lys Ser 
145                 150                 155                 160 


Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp Asn Thr 
                165                 170                 175     


Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met Asp Ala 
            180                 185                 190         


Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr Gln Asp 
        195                 200                 205             


Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala Ala Leu 
    210                 215                 220                 


Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe Ser Pro 
225                 230                 235                 240 


Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro 
                245                 250                 255     


Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro Gly Pro 
            260                 265                 270         


Ser Pro Ser Pro Gln 
        275         


<210> 6416
<211> 437
<212> PRT
<213> Homo sapiens

<400> 6416
Met Ala Gly Gly Pro Pro Lys Ala Leu Pro Ser Thr Gly Pro His Ser 
1               5                   10                  15      


Leu Arg Asp Met Pro His Pro Leu Ala Gly Ser Ser Ser Glu Glu Ala 
            20                  25                  30          


Val Gly Gly Asp Ser Thr Pro Ser Pro Asp Leu Leu Met Ala Arg Ser 
        35                  40                  45              


Phe Gly Asp Lys Asp Leu Ile Leu Pro Asn Gly Gly Thr Pro Ala Gly 
    50                  55                  60                  


Thr Ser Ser Pro Ala Ser Ser Ser Ser Leu Leu Asn Arg Leu Gln Leu 
65                  70                  75                  80  


Asp Asp Asp Ile Asp Gly Glu Thr Arg Asp Leu Phe Val Ile Val Asp 
                85                  90                  95      


Asp Pro Lys Lys His Val Cys Thr Met Glu Thr Tyr Ile Thr Tyr Arg 
            100                 105                 110         


Ile Thr Thr Lys Ser Thr Arg Val Glu Phe Asp Leu Pro Glu Tyr Ser 
        115                 120                 125             


Val Arg Arg Arg Tyr Gln Asp Phe Asp Trp Leu Arg Ser Lys Leu Glu 
    130                 135                 140                 


Glu Ser Gln Pro Thr His Leu Ile Pro Pro Leu Pro Glu Lys Phe Val 
145                 150                 155                 160 


Val Lys Gly Val Val Asp Arg Phe Ser Glu Glu Phe Val Glu Thr Arg 
                165                 170                 175     


Arg Lys Ala Leu Asp Lys Phe Leu Lys Arg Ile Thr Asp His Pro Val 
            180                 185                 190         


Leu Ser Phe Asn Glu His Phe Asn Ile Phe Leu Thr Ala Lys Asp Leu 
        195                 200                 205             


Asn Ala Tyr Lys Lys Gln Gly Ile Ala Leu Leu Thr Arg Met Gly Glu 
    210                 215                 220                 


Ser Val Lys His Val Thr Gly Gly Tyr Lys Leu Arg Thr Arg Pro Leu 
225                 230                 235                 240 


Glu Phe Ala Ala Ile Gly Asp Tyr Leu Asp Thr Phe Ala Leu Lys Leu 
                245                 250                 255     


Gly Thr Ile Asp Arg Ile Ala Gln Arg Ile Ile Lys Glu Glu Ile Glu 
            260                 265                 270         


Tyr Leu Val Glu Leu Arg Glu Tyr Gly Pro Val Tyr Ser Thr Trp Ser 
        275                 280                 285             


Ala Leu Glu Gly Glu Leu Ala Glu Pro Leu Glu Gly Val Ser Ala Cys 
    290                 295                 300                 


Ile Gly Asn Cys Ser Thr Ala Leu Glu Glu Leu Thr Asp Asp Met Thr 
305                 310                 315                 320 


Glu Asp Phe Leu Pro Val Leu Arg Glu Tyr Ile Leu Tyr Ser Asp Ser 
                325                 330                 335     


Met Lys Ser Val Leu Lys Lys Arg Asp Gln Val Gln Ala Glu Tyr Glu 
            340                 345                 350         


Ala Lys Leu Glu Ala Val Ala Leu Arg Lys Glu Asp Arg Pro Lys Val 
        355                 360                 365             


Pro Ala Asp Val Glu Lys Cys Gln Asp Arg Met Glu Cys Phe Asn Ala 
    370                 375                 380                 


Asp Leu Lys Ala Asp Met Glu Arg Trp Gln Asn Asn Lys Arg Gln Asp 
385                 390                 395                 400 


Phe Arg Gln Leu Leu Met Gly Met Ala Asp Lys Asn Ile Gln Tyr Tyr 
                405                 410                 415     


Glu Lys Cys Leu Met Ala Trp Glu Ser Ile Ile Pro Leu Leu Gln Glu 
            420                 425                 430         


Lys Gln Glu Ala Lys 
        435         


<210> 6417
<211> 420
<212> PRT
<213> Homo sapiens

<400> 6417
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175     


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190         


Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr 
        195                 200                 205             


Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe 
    210                 215                 220                 


Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp 
225                 230                 235                 240 


Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg 
                245                 250                 255     


Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser 
            260                 265                 270         


Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn 
        275                 280                 285             


Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu 
    290                 295                 300                 


Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys 
305                 310                 315                 320 


Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr 
                325                 330                 335     


Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His 
            340                 345                 350         


Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val 
        355                 360                 365             


Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile 
    370                 375                 380                 


Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu 
385                 390                 395                 400 


Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu 
                405                 410                 415     


Leu Thr Leu Asp 
            420 


<210> 6418
<211> 278
<212> PRT
<213> Homo sapiens

<400> 6418
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe 
                165                 170                 175     


Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile 
            180                 185                 190         


Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val 
        195                 200                 205             


Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val 
    210                 215                 220                 


Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met 
225                 230                 235                 240 


Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr 
                245                 250                 255     


Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg 
            260                 265                 270         


Lys Leu Leu Thr Leu Asp 
        275             


<210> 6419
<211> 226
<212> PRT
<213> Homo sapiens

<400> 6419
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175     


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190         


Leu Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr 
        195                 200                 205             


Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr 
    210                 215                 220                 


Cys Ala 
225     


<210> 6420
<211> 226
<212> PRT
<213> Homo sapiens

<400> 6420
Met His Gln Thr Cys Val Arg Leu Glu Arg Glu Ala Ser Ala Arg Pro 
1               5                   10                  15      


Ser Pro Gly Pro Val Leu Pro Pro Arg Pro Leu Pro Ser His Thr Glu 
            20                  25                  30          


Leu Gln Ile Arg Glu Gly Pro Lys Arg Thr Ile Arg Ala Ala Ala Glu 
        35                  40                  45              


Gly Ala Pro Cys Val Gly Arg Val Arg Cys Ala Pro Gly Asn Arg Gly 
    50                  55                  60                  


Gly Arg Glu Gly Ala Ser Gly Val Arg Gly Gly Val Ala Gln Val Pro 
65                  70                  75                  80  


Pro Arg Leu Pro Ala Pro Pro Ile Gly Pro Glu Arg Asp Asp Leu Ala 
                85                  90                  95      


Gly Gly Ala Gly Arg Lys Pro Leu Pro Ser Thr Ala Ala Ala Ser Ser 
            100                 105                 110         


Pro Gly Ser Ala Ala Ala Ala Thr Ala Ala Leu Cys Pro Pro Ala Arg 
        115                 120                 125             


Leu Ser Thr Pro Ser Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val 
    130                 135                 140                 


Thr Gly Ser Arg Glu Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile 
145                 150                 155                 160 


Leu Asp Gly Lys Arg Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp 
                165                 170                 175     


Asn Ala Leu Arg Asp Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala 
            180                 185                 190         


Thr Pro Pro Gln Ile Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu 
        195                 200                 205             


Leu Phe Val Glu Ala Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys 
    210                 215                 220                 


Leu Ala 
225     


<210> 6421
<211> 505
<212> PRT
<213> Homo sapiens

<400> 6421
Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile 
1               5                   10                  15      


Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro 
        35                  40                  45              


Glu Val Glu Pro Asp Leu Gly Glu Lys Val His Thr Glu Gly Arg Ser 
    50                  55                  60                  


Glu Pro Ile Leu Leu Pro Ser Arg Leu Pro Glu Pro Ala Gly Gly Pro 
65                  70                  75                  80  


Gln Pro Gly Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser 
                85                  90                  95      


Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln 
            100                 105                 110         


Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr 
        115                 120                 125             


Glu Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser 
    130                 135                 140                 


Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu 
145                 150                 155                 160 


His Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser 
                165                 170                 175     


Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg 
            180                 185                 190         


Arg Arg Ala Ala Ser Met Asp Ser Ser Ser Lys Leu Leu Arg Gly Arg 
        195                 200                 205             


Ser Lys Ala Pro Lys Lys Lys Pro Ser Val Leu Pro Ala Pro Pro Glu 
    210                 215                 220                 


Gly Ala Thr Pro Thr Ser Pro Val Gly His Phe Ala Lys Trp Ser Gly 
225                 230                 235                 240 


Ser Pro Cys Ser Arg Asn Arg Glu Glu Ala Asp Met Trp Thr Thr Phe 
                245                 250                 255     


Arg Pro Arg Ser Ser Ser Asn Ala Ser Ser Val Ser Thr Arg Leu Ser 
            260                 265                 270         


Pro Leu Arg Pro Glu Ser Glu Val Leu Ala Glu Glu Ile Pro Ala Ser 
        275                 280                 285             


Val Ser Ser Tyr Ala Gly Gly Val Pro Pro Thr Leu Asn Glu Gly Leu 
    290                 295                 300                 


Glu Leu Leu Asp Gly Leu Asn Leu Thr Ser Ser His Ser Leu Leu Ser 
305                 310                 315                 320 


Arg Ser Gly Leu Ser Gly Phe Ser Leu Gln His Pro Gly Val Thr Gly 
                325                 330                 335     


Pro Leu His Thr Tyr Ser Ser Ser Leu Phe Ser Pro Ala Glu Gly Pro 
            340                 345                 350         


Leu Ser Ala Gly Glu Gly Cys Phe Ser Ser Ser Gln Ala Leu Glu Ala 
        355                 360                 365             


Leu Leu Thr Ser Asp Thr Pro Pro Pro Pro Ala Asp Val Leu Met Thr 
    370                 375                 380                 


Gln Val Asp Pro Ile Leu Ser Gln Ala Pro Thr Leu Leu Leu Leu Gly 
385                 390                 395                 400 


Gly Leu Pro Ser Ser Ser Lys Leu Ala Thr Gly Val Gly Leu Cys Pro 
                405                 410                 415     


Lys Pro Leu Glu Ala Pro Gly Pro Ser Ser Leu Val Pro Thr Leu Ser 
            420                 425                 430         


Met Ile Ala Pro Pro Pro Val Met Ala Ser Ala Pro Ile Pro Lys Ala 
        435                 440                 445             


Leu Gly Thr Pro Val Leu Thr Pro Pro Thr Glu Ala Ala Ser Gln Asp 
    450                 455                 460                 


Arg Met Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu 
465                 470                 475                 480 


Cys Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly 
                485                 490                 495     


Leu Asp Phe Asn Phe Glu Pro Asp Pro 
            500                 505 


<210> 6422
<211> 353
<212> PRT
<213> Homo sapiens

<400> 6422
Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
1               5                   10                  15      


Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
            20                  25                  30          


Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
        35                  40                  45              


Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
    50                  55                  60                  


Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
65                  70                  75                  80  


Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                85                  90                  95      


Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
            100                 105                 110         


Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
        115                 120                 125             


Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
    130                 135                 140                 


Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
145                 150                 155                 160 


Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                165                 170                 175     


Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
            180                 185                 190         


Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
        195                 200                 205             


Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
225                 230                 235                 240 


Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                245                 250                 255     


Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
            260                 265                 270         


Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
        275                 280                 285             


Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
    290                 295                 300                 


Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                325                 330                 335     


Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
            340                 345                 350         


Gln 
    


<210> 6423
<211> 392
<212> PRT
<213> Homo sapiens

<400> 6423
Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210> 6424
<211> 392
<212> PRT
<213> Homo sapiens

<400> 6424
Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210> 6425
<211> 70
<212> PRT
<213> Homo sapiens

<400> 6425
Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys 
65                  70  


<210> 6426
<211> 70
<212> PRT
<213> Homo sapiens

<400> 6426
Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys 
65                  70  


<210> 6427
<211> 177
<212> PRT
<213> Homo sapiens

<400> 6427
Met Pro Gly Leu Thr Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val 
1               5                   10                  15      


Lys Gly Gly Glu Thr Val Met Val Asn Ala Ala Ala Gly Ala Val Gly 
            20                  25                  30          


Ser Val Val Gly Gln Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly 
        35                  40                  45              


Ala Val Gly Ser Asp Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe 
    50                  55                  60                  


Asp Val Val Phe Asn Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu 
65                  70                  75                  80  


Lys Lys Ala Ser Pro Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly 
                85                  90                  95      


Gly Glu Phe Ser Asn Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg 
            100                 105                 110         


Ile Ala Ile Cys Gly Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu 
        115                 120                 125             


Pro Pro Gly Pro Pro Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met 
    130                 135                 140                 


Glu Ala Phe Val Val Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala 
145                 150                 155                 160 


Leu Lys Asp Leu Leu Lys Trp Val Leu Glu Leu Pro Tyr Phe Val Ile 
                165                 170                 175     


Asp 
    


<210> 6428
<211> 420
<212> PRT
<213> Homo sapiens

<400> 6428
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175     


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190         


Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr 
        195                 200                 205             


Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe 
    210                 215                 220                 


Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp 
225                 230                 235                 240 


Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg 
                245                 250                 255     


Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser 
            260                 265                 270         


Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn 
        275                 280                 285             


Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu 
    290                 295                 300                 


Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys 
305                 310                 315                 320 


Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr 
                325                 330                 335     


Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His 
            340                 345                 350         


Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val 
        355                 360                 365             


Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile 
    370                 375                 380                 


Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu 
385                 390                 395                 400 


Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu 
                405                 410                 415     


Leu Thr Leu Asp 
            420 


<210> 6429
<211> 278
<212> PRT
<213> Homo sapiens

<400> 6429
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe 
                165                 170                 175     


Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile 
            180                 185                 190         


Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val 
        195                 200                 205             


Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val 
    210                 215                 220                 


Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met 
225                 230                 235                 240 


Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr 
                245                 250                 255     


Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg 
            260                 265                 270         


Lys Leu Leu Thr Leu Asp 
        275             


<210> 6430
<211> 226
<212> PRT
<213> Homo sapiens

<400> 6430
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175     


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190         


Leu Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr 
        195                 200                 205             


Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr 
    210                 215                 220                 


Cys Ala 
225     


<210> 6431
<211> 262
<212> PRT
<213> Homo sapiens

<400> 6431
Met Ser Arg Tyr Leu Arg Pro Pro Asn Thr Ser Leu Phe Val Arg Asn 
1               5                   10                  15      


Val Ala Asp Asp Thr Arg Ser Glu Asp Leu Arg Arg Glu Phe Gly Arg 
            20                  25                  30          


Tyr Gly Pro Ile Val Asp Val Tyr Val Pro Leu Asp Phe Tyr Thr Arg 
        35                  40                  45              


Arg Pro Arg Gly Phe Ala Tyr Val Gln Phe Glu Asp Val Arg Asp Ala 
    50                  55                  60                  


Glu Asp Ala Leu His Asn Leu Asp Arg Lys Trp Ile Cys Gly Arg Gln 
65                  70                  75                  80  


Ile Glu Ile Gln Phe Ala Gln Gly Asp Arg Lys Thr Pro Asn Gln Met 
                85                  90                  95      


Lys Ala Lys Glu Gly Arg Asn Val Tyr Ser Ser Ser Arg Tyr Asp Asp 
            100                 105                 110         


Tyr Asp Arg Tyr Arg Arg Ser Arg Ser Arg Ser Tyr Glu Arg Arg Arg 
        115                 120                 125             


Ser Arg Ser Arg Ser Phe Asp Tyr Asn Tyr Arg Arg Ser Tyr Ser Pro 
    130                 135                 140                 


Arg Asn Ser Arg Pro Thr Gly Arg Pro Arg Arg Ser Arg Ser His Ser 
145                 150                 155                 160 


Asp Asn Asp Arg Phe Lys His Arg Asn Arg Ser Phe Ser Arg Ser Lys 
                165                 170                 175     


Ser Asn Ser Arg Ser Arg Ser Lys Ser Gln Pro Lys Lys Glu Met Lys 
            180                 185                 190         


Ala Lys Ser Arg Ser Arg Ser Ala Ser His Thr Lys Thr Arg Gly Thr 
        195                 200                 205             


Ser Lys Thr Asp Ser Lys Thr His Tyr Lys Ser Gly Ser Arg Tyr Glu 
    210                 215                 220                 


Lys Glu Ser Arg Lys Lys Glu Pro Pro Arg Ser Lys Ser Gln Ser Arg 
225                 230                 235                 240 


Ser Gln Ser Arg Ser Arg Ser Lys Ser Arg Ser Arg Ser Trp Thr Ser 
                245                 250                 255     


Pro Lys Ser Ser Gly His 
            260         


<210> 6432
<211> 173
<212> PRT
<213> Homo sapiens

<400> 6432
Met Ser Arg Tyr Leu Arg Pro Pro Asn Thr Ser Leu Phe Val Arg Asn 
1               5                   10                  15      


Val Ala Asp Asp Thr Arg Ser Glu Asp Leu Arg Arg Glu Phe Gly Arg 
            20                  25                  30          


Tyr Gly Pro Ile Val Asp Val Tyr Val Pro Leu Asp Phe Tyr Thr Arg 
        35                  40                  45              


Arg Pro Arg Gly Phe Ala Tyr Val Gln Phe Glu Asp Val Arg Asp Ala 
    50                  55                  60                  


Glu Asp Ala Leu His Asn Leu Asp Arg Lys Trp Ile Cys Gly Arg Gln 
65                  70                  75                  80  


Ile Glu Ile Gln Phe Ala Gln Gly Asp Arg Lys Thr Pro Asn Gln Met 
                85                  90                  95      


Lys Ala Lys Glu Gly Arg Asn Val Tyr Ser Ser Ser Arg Tyr Asp Asp 
            100                 105                 110         


Tyr Asp Arg Tyr Arg Arg Ser Arg Ser Arg Ser Tyr Glu Arg Arg Arg 
        115                 120                 125             


Ser Arg Ser Arg Ser Phe Asp Tyr Asn Tyr Arg Arg Ser Tyr Ser Pro 
    130                 135                 140                 


Arg Asn Ser Arg Pro Thr Gly Arg Pro Arg Arg Ser Arg Ser His Ser 
145                 150                 155                 160 


Asp Asn Asp Ser Gln Val Ser Lys Lys Lys Asn Glu Arg 
                165                 170             


<210> 6433
<211> 222
<212> PRT
<213> Homo sapiens

<400> 6433
Met Ser Ala Phe Gly His Asp Glu Ala Trp Met Glu Ala Gly Gly Phe 
1               5                   10                  15      


Gly Leu Glu Ala Ala Glu Arg Thr Glu Tyr Gln Ser Leu Cys Lys Ser 
            20                  25                  30          


Lys Leu Leu Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Ile Ile 
        35                  40                  45              


Ser Arg Phe Met Tyr Asn Ser Phe Gly Cys Ala Cys Gln Ala Thr Val 
    50                  55                  60                  


Gly Ile Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Gln Ile Val 
65                  70                  75                  80  


Gln Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe His Ser Leu 
                85                  90                  95      


Ile Pro Ser Tyr Ile Arg Asp Ser Thr Ile Ala Val Val Val Tyr Asp 
            100                 105                 110         


Ile Thr Asn Ile Asn Ser Phe Lys Glu Thr Asp Lys Trp Val Glu His 
        115                 120                 125             


Val Arg Ala Glu Arg Gly Asp Asp Val Val Ile Met Leu Leu Gly Asn 
    130                 135                 140                 


Lys Ile Asp Leu Asp Asn Lys Arg Gln Val Thr Ala Glu Gln Gly Glu 
145                 150                 155                 160 


Glu Lys Ser Arg Asn Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys 
                165                 170                 175     


Thr Gly Tyr Asn Val Lys Lys Leu Phe Arg Arg Val Ala Ser Ala Leu 
            180                 185                 190         


Leu Ser Thr Arg Thr Ser Pro Pro Pro Lys Glu Gly Thr Val Glu Ile 
        195                 200                 205             


Glu Leu Glu Ser Phe Glu Glu Ser Gly Asn Arg Ser Tyr Cys 
    210                 215                 220         


<210> 6434
<211> 115
<212> PRT
<213> Homo sapiens

<400> 6434
Met Val Gln Ile Ile Lys Asp Thr Asn Glu Phe Lys Thr Phe Leu Thr 
1               5                   10                  15      


Ala Ala Gly His Lys Leu Ala Val Val Gln Phe Ser Ser Lys Arg Cys 
            20                  25                  30          


Gly Pro Cys Lys Arg Met Phe Pro Val Phe His Ala Met Ser Val Lys 
        35                  40                  45              


Tyr Gln Asn Val Phe Phe Ala Asn Val Asp Val Asn Asn Ser Pro Glu 
    50                  55                  60                  


Leu Ala Glu Thr Cys His Ile Lys Thr Ile Pro Thr Phe Gln Met Phe 
65                  70                  75                  80  


Lys Lys Ser Gln Lys Val Thr Leu Phe Ser Arg Ile Lys Arg Ile Ile 
                85                  90                  95      


Cys Cys Tyr Arg Ser Gly Phe Met Ser Asn Leu Cys Leu Ala Asp Asp 
            100                 105                 110         


Gly Asn Glu 
        115 


<210> 6435
<211> 127
<212> PRT
<213> Homo sapiens

<400> 6435
Met Val Gln Ile Ile Lys Asp Thr Asn Glu Phe Lys Thr Phe Leu Thr 
1               5                   10                  15      


Ala Ala Gly His Lys Leu Ala Val Val Gln Phe Ser Ser Lys Arg Cys 
            20                  25                  30          


Gly Pro Cys Lys Arg Met Phe Pro Val Phe His Ala Met Ser Val Lys 
        35                  40                  45              


Tyr Gln Asn Val Phe Phe Ala Asn Val Asp Val Asn Asn Ser Pro Glu 
    50                  55                  60                  


Leu Ala Glu Thr Cys His Ile Lys Thr Ile Pro Thr Phe Gln Met Phe 
65                  70                  75                  80  


Lys Lys Ser Gln Lys Val Thr Leu Phe Ser Arg Ile Lys Arg Ile Ile 
                85                  90                  95      


Cys Cys Tyr Arg Ser Gly Phe Met Ser Asn Leu Ile Phe Glu Phe Cys 
            100                 105                 110         


Gly Ala Asp Ala Lys Lys Leu Glu Ala Lys Thr Gln Glu Leu Met 
        115                 120                 125         


<210> 6436
<211> 588
<212> PRT
<213> Homo sapiens

<400> 6436
Met His Arg Ser Ala Pro Ser Gln Thr Thr Lys Arg Ser Arg Ser Pro 
1               5                   10                  15      


Phe Ser Thr Thr Arg Arg Ser Trp Asp Asp Ser Glu Ser Ser Gly Thr 
            20                  25                  30          


Asn Leu Asn Ile Asp Asn Glu Asp Tyr Ser Arg Tyr Pro Pro Arg Glu 
        35                  40                  45              


Tyr Arg Ala Ser Gly Ser Arg Arg Gly Met Ala Tyr Gly His Ile Asp 
    50                  55                  60                  


Ser Tyr Gly Ala Asp Asp Ser Glu Glu Glu Gly Ala Gly Pro Val Glu 
65                  70                  75                  80  


Arg Pro Pro Val Arg Gly Lys Thr Gly Lys Phe Lys Asp Asp Lys Leu 
                85                  90                  95      


Tyr Asp Pro Glu Lys Gly Ala Arg Ser Leu Ala Gly Pro Pro Pro His 
            100                 105                 110         


Phe Ser Ser Phe Ser Arg Asp Val Arg Glu Glu Arg Asp Lys Leu Asp 
        115                 120                 125             


Pro Val Pro Ala Ala Arg Cys Ser Ala Ser Arg Ala Asp Phe Leu Pro 
    130                 135                 140                 


Gln Ser Ser Val Ala Ser Gln Ser Ser Ser Glu Gly Lys Leu Ala Thr 
145                 150                 155                 160 


Lys Gly Asp Ser Ser Glu Arg Glu Arg Arg Glu Gln Asn Leu Pro Ala 
                165                 170                 175     


Arg Pro Ser Arg Ala Pro Val Ser Ile Cys Gly Gly Gly Glu Asn Thr 
            180                 185                 190         


Ser Lys Ser Ala Glu Glu Pro Val Val Arg Pro Lys Ile Arg Asn Leu 
        195                 200                 205             


Ala Ser Pro Asn Cys Val Lys Pro Lys Ile Phe Phe Asp Thr Asp Asp 
    210                 215                 220                 


Asp Asp Asp Met Pro His Ser Thr Ser Arg Trp Arg Asp Thr Ala Asn 
225                 230                 235                 240 


Asp Asn Glu Gly His Ser Asp Gly Leu Ala Arg Arg Gly Arg Gly Glu 
                245                 250                 255     


Ser Ser Ser Gly Tyr Pro Glu Pro Lys Tyr Pro Glu Asp Lys Arg Glu 
            260                 265                 270         


Ala Arg Ser Asp Gln Val Lys Pro Glu Lys Val Pro Arg Arg Arg Arg 
        275                 280                 285             


Thr Met Ala Asp Pro Asp Phe Trp Thr His Ser Asp Asp Tyr Tyr Lys 
    290                 295                 300                 


Tyr Cys Asp Glu Asp Ser Asp Ser Asp Lys Glu Trp Ile Ala Ala Leu 
305                 310                 315                 320 


Arg Arg Lys Tyr Arg Ser Arg Glu Gln Thr Leu Ser Ser Ser Gly Glu 
                325                 330                 335     


Ser Trp Glu Thr Leu Pro Gly Lys Glu Glu Arg Glu Pro Pro Gln Ala 
            340                 345                 350         


Lys Val Ser Ala Ser Thr Gly Thr Ser Pro Gly Pro Gly Ala Ser Ala 
        355                 360                 365             


Ser Ala Gly Ala Gly Ala Gly Ala Ser Ala Gly Ser Asn Gly Ser Asn 
    370                 375                 380                 


Tyr Leu Glu Glu Val Arg Glu Pro Ser Leu Gln Glu Glu Gln Ala Ser 
385                 390                 395                 400 


Leu Glu Glu Gly Glu Ile Pro Trp Leu Gln Tyr His Glu Asn Asp Ser 
                405                 410                 415     


Ser Ser Glu Gly Asp Asn Asp Ser Gly His Glu Leu Met Gln Pro Gly 
            420                 425                 430         


Val Phe Met Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val 
        435                 440                 445             


Ser Glu Asp Leu Glu Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp 
    450                 455                 460                 


Gly Leu Gly Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu 
465                 470                 475                 480 


Thr Tyr Met Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala 
                485                 490                 495     


Leu Ala His Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro 
            500                 505                 510         


Pro Ala Ser Lys Glu Ser Ile Asp Ala Leu Pro Glu Ile Leu Val Thr 
        515                 520                 525             


Glu Asp His Gly Ala Val Gly Gln Glu Met Cys Cys Pro Ile Cys Cys 
    530                 535                 540                 


Ser Glu Tyr Val Lys Gly Glu Val Ala Thr Glu Leu Pro Cys His His 
545                 550                 555                 560 


Tyr Phe His Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr 
                565                 570                 575     


Cys Pro Val Cys Arg Cys Met Phe Pro Pro Pro Leu 
            580                 585             


<210> 6437
<211> 203
<212> PRT
<213> Homo sapiens

<400> 6437
Met Pro Glu Gln Phe Ser Val Ala Glu Phe Leu Ala Val Thr Ala Glu 
1               5                   10                  15      


Asp Leu Ser Ser Pro Ala Gly Ala Ala Ala Phe Ala Ala Lys Met Pro 
            20                  25                  30          


Arg Tyr Arg Gly Ala Ala Leu Ala Arg Glu Glu Ile Leu Glu Gly Asp 
        35                  40                  45              


Gln Ala Ile Leu Gln Arg Ile Lys Lys Ala Val Arg Ala Ile His Ser 
    50                  55                  60                  


Ser Gly Leu Gly His Val Glu Asn Glu Glu Gln Tyr Arg Glu Ala Val 
65                  70                  75                  80  


Glu Ser Leu Gly Asn Ser His Leu Ser Gln Asn Ser His Glu Leu Ser 
                85                  90                  95      


Thr Gly Phe Leu Asn Leu Ala Val Phe Thr Arg Glu Val Ala Ala Leu 
            100                 105                 110         


Phe Lys Asn Leu Ile Gln Asn Leu Asn Asn Ile Val Ser Phe Pro Leu 
        115                 120                 125             


Asp Ser Leu Met Lys Gly Gln Leu Arg Asp Gly Arg Gln Asp Ser Lys 
    130                 135                 140                 


Lys Gln Leu Glu Lys Ala Trp Lys Asp Tyr Glu Ala Lys Met Ala Lys 
145                 150                 155                 160 


Leu Glu Lys Glu Arg Asp Arg Ala Arg Val Thr Gly Gly Ile Pro Ala 
                165                 170                 175     


Trp Asn Leu Gly Ile Pro Ala Lys Pro His Pro Thr Leu Lys Arg Ala 
            180                 185                 190         


Ser Glu Ser Pro Gln Ala Pro Pro Asp Pro Ala 
        195                 200             


<210> 6438
<211> 643
<212> PRT
<213> Homo sapiens

<400> 6438
Met Gly Gln Glu Ser Ser Lys Pro Val Trp Pro Asn Pro Thr Gly Gly 
1               5                   10                  15      


Tyr Gln Ser Asn Thr Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val 
            20                  25                  30          


Ser Phe Arg Pro Pro Thr Ser Gln Arg Glu Arg Ile Ala Ser Gln Arg 
        35                  40                  45              


Lys Thr Asn Ser Glu Val Pro Met His Arg Ser Ala Pro Ser Gln Thr 
    50                  55                  60                  


Thr Lys Arg Ser Arg Ser Pro Phe Ser Thr Thr Arg Arg Ser Trp Asp 
65                  70                  75                  80  


Asp Ser Glu Ser Ser Gly Thr Asn Leu Asn Ile Asp Asn Glu Asp Tyr 
                85                  90                  95      


Ser Arg Tyr Pro Pro Arg Glu Tyr Arg Ala Ser Gly Ser Arg Arg Gly 
            100                 105                 110         


Met Ala Tyr Gly His Ile Asp Ser Tyr Gly Ala Asp Asp Ser Glu Glu 
        115                 120                 125             


Glu Gly Ala Gly Pro Val Glu Arg Pro Pro Val Arg Gly Lys Thr Gly 
    130                 135                 140                 


Lys Phe Lys Asp Asp Lys Leu Tyr Asp Pro Glu Lys Gly Ala Arg Ser 
145                 150                 155                 160 


Leu Ala Gly Pro Pro Pro His Phe Ser Ser Phe Ser Arg Asp Val Arg 
                165                 170                 175     


Glu Glu Arg Asp Lys Leu Asp Pro Val Pro Ala Ala Arg Cys Ser Ala 
            180                 185                 190         


Ser Arg Ala Asp Phe Leu Pro Gln Ser Ser Val Ala Ser Gln Ser Ser 
        195                 200                 205             


Ser Glu Gly Lys Leu Ala Thr Lys Gly Asp Ser Ser Glu Arg Glu Arg 
    210                 215                 220                 


Arg Glu Gln Asn Leu Pro Ala Arg Pro Ser Arg Ala Pro Val Ser Ile 
225                 230                 235                 240 


Cys Gly Gly Gly Glu Asn Thr Ser Lys Ser Ala Glu Glu Pro Val Val 
                245                 250                 255     


Arg Pro Lys Ile Arg Asn Leu Ala Ser Pro Asn Cys Val Lys Pro Lys 
            260                 265                 270         


Ile Phe Phe Asp Thr Asp Asp Asp Asp Asp Met Pro His Ser Thr Ser 
        275                 280                 285             


Arg Trp Arg Asp Thr Ala Asn Asp Asn Glu Gly His Ser Asp Gly Leu 
    290                 295                 300                 


Ala Arg Arg Gly Arg Gly Glu Ser Ser Ser Gly Tyr Pro Glu Pro Lys 
305                 310                 315                 320 


Tyr Pro Glu Asp Lys Arg Glu Ala Arg Ser Asp Gln Val Lys Pro Glu 
                325                 330                 335     


Lys Val Pro Arg Arg Arg Arg Thr Met Ala Asp Pro Asp Phe Trp Thr 
            340                 345                 350         


His Ser Asp Asp Tyr Tyr Lys Tyr Cys Asp Glu Asp Ser Asp Ser Asp 
        355                 360                 365             


Lys Glu Trp Ile Ala Ala Leu Arg Arg Lys Tyr Arg Ser Arg Glu Gln 
    370                 375                 380                 


Thr Leu Ser Ser Ser Gly Glu Ser Trp Glu Thr Leu Pro Gly Lys Glu 
385                 390                 395                 400 


Glu Arg Glu Pro Pro Gln Ala Lys Val Ser Ala Ser Thr Gly Thr Ser 
                405                 410                 415     


Pro Gly Pro Gly Ala Ser Ala Ser Ala Gly Ala Gly Ala Gly Ala Ser 
            420                 425                 430         


Ala Gly Ser Asn Gly Ser Asn Tyr Leu Glu Glu Val Arg Glu Pro Ser 
        435                 440                 445             


Leu Gln Glu Glu Gln Ala Ser Leu Glu Glu Gly Glu Ile Pro Trp Leu 
    450                 455                 460                 


Gln Tyr His Glu Asn Asp Ser Ser Ser Glu Gly Asp Asn Asp Ser Gly 
465                 470                 475                 480 


His Glu Leu Met Gln Pro Gly Val Phe Met Leu Asp Gly Asn Asn Asn 
                485                 490                 495     


Leu Glu Asp Asp Ser Ser Val Ser Glu Asp Leu Glu Val Asp Trp Ser 
            500                 505                 510         


Leu Phe Asp Gly Phe Ala Asp Gly Leu Gly Val Ala Glu Ala Ile Ser 
        515                 520                 525             


Tyr Val Asp Pro Gln Phe Leu Thr Tyr Met Ala Leu Glu Glu Arg Leu 
    530                 535                 540                 


Ala Gln Ala Met Glu Thr Ala Leu Ala His Leu Glu Ser Leu Ala Val 
545                 550                 555                 560 


Asp Val Glu Val Ala Asn Pro Pro Ala Ser Lys Glu Ser Ile Asp Ala 
                565                 570                 575     


Leu Pro Glu Ile Leu Val Thr Glu Asp His Gly Ala Val Gly Gln Glu 
            580                 585                 590         


Met Cys Cys Pro Ile Cys Cys Ser Glu Tyr Val Lys Gly Glu Val Ala 
        595                 600                 605             


Thr Glu Leu Pro Cys His His Tyr Phe His Lys Pro Cys Val Ser Ile 
    610                 615                 620                 


Trp Leu Gln Lys Ser Gly Thr Cys Pro Val Cys Arg Cys Met Phe Pro 
625                 630                 635                 640 


Pro Pro Leu 
            


<210> 6439
<211> 455
<212> PRT
<213> Homo sapiens

<400> 6439
Met Gly Gln Glu Ser Ser Lys Pro Val Trp Pro Asn Pro Thr Gly Gly 
1               5                   10                  15      


Tyr Gln Ser Asn Thr Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val 
            20                  25                  30          


Ser Phe Arg Pro Pro Thr Ser Gln Arg Glu Arg Ile Ala Ser Gln Arg 
        35                  40                  45              


Lys Thr Asn Ser Glu Val Pro Met His Arg Ser Ala Pro Ser Gln Thr 
    50                  55                  60                  


Thr Lys Arg Ser Arg Ser Pro Phe Ser Thr Thr Arg Arg Ser Trp Asp 
65                  70                  75                  80  


Asp Ser Glu Ser Ser Gly Thr Asn Leu Asn Ile Asp Asn Glu Asp Tyr 
                85                  90                  95      


Ser Ser Thr Ser Arg Trp Arg Asp Thr Ala Asn Asp Asn Glu Gly His 
            100                 105                 110         


Ser Asp Gly Leu Ala Arg Arg Gly Arg Gly Glu Ser Ser Ser Gly Tyr 
        115                 120                 125             


Pro Glu Pro Lys Tyr Pro Glu Asp Lys Arg Glu Ala Arg Ser Asp Gln 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Pro Arg Arg Arg Arg Thr Met Ala Asp Pro 
145                 150                 155                 160 


Asp Phe Trp Thr His Ser Asp Asp Tyr Tyr Lys Tyr Cys Asp Glu Asp 
                165                 170                 175     


Ser Asp Ser Asp Lys Glu Trp Ile Ala Ala Leu Arg Arg Lys Tyr Arg 
            180                 185                 190         


Ser Arg Glu Gln Thr Leu Ser Ser Ser Gly Glu Ser Trp Glu Thr Leu 
        195                 200                 205             


Pro Gly Lys Glu Glu Arg Glu Pro Pro Gln Ala Lys Val Ser Ala Ser 
    210                 215                 220                 


Thr Gly Thr Ser Pro Gly Pro Gly Ala Ser Ala Ser Ala Gly Ala Gly 
225                 230                 235                 240 


Ala Gly Ala Ser Ala Gly Ser Asn Gly Ser Asn Tyr Leu Glu Glu Val 
                245                 250                 255     


Arg Glu Pro Ser Leu Gln Glu Glu Gln Ala Ser Leu Glu Glu Gly Glu 
            260                 265                 270         


Ile Pro Trp Leu Gln Tyr His Glu Asn Asp Ser Ser Ser Glu Gly Asp 
        275                 280                 285             


Asn Asp Ser Gly His Glu Leu Met Gln Pro Gly Val Phe Met Leu Asp 
    290                 295                 300                 


Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu Asp Leu Glu 
305                 310                 315                 320 


Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu Gly Val Ala 
                325                 330                 335     


Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr Met Ala Leu 
            340                 345                 350         


Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala His Leu Glu 
        355                 360                 365             


Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala Ser Lys Glu 
    370                 375                 380                 


Ser Ile Asp Ala Leu Pro Glu Ile Leu Val Thr Glu Asp His Gly Ala 
385                 390                 395                 400 


Val Gly Gln Glu Met Cys Cys Pro Ile Cys Cys Ser Glu Tyr Val Lys 
                405                 410                 415     


Gly Glu Val Ala Thr Glu Leu Pro Cys His His Tyr Phe His Lys Pro 
            420                 425                 430         


Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro Val Cys Arg 
        435                 440                 445             


Cys Met Phe Pro Pro Pro Leu 
    450                 455 


<210> 6440
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6440
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 6441
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6441
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 6442
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6442
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 6443
<211> 503
<212> PRT
<213> Homo sapiens

<400> 6443
Met Lys Cys Glu His Cys Thr Arg Lys Glu Cys Ser Lys Lys Thr Lys 
1               5                   10                  15      


Thr Asp Asp Gln Glu Asn Val Ser Ala Asp Ala Pro Ser Pro Ala Gln 
            20                  25                  30          


Glu Asn Gly Glu Lys Gly Glu Phe His Lys Leu Ala Asp Ala Lys Ile 
        35                  40                  45              


Phe Leu Ser Asp Cys Leu Ala Cys Asp Ser Cys Met Thr Ala Glu Glu 
    50                  55                  60                  


Gly Val Gln Leu Ser Gln Gln Asn Ala Lys Asp Phe Phe Arg Val Leu 
65                  70                  75                  80  


Asn Leu Asn Lys Lys Cys Asp Thr Ser Lys His Lys Val Leu Val Val 
                85                  90                  95      


Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala Ala Lys Phe Asn Leu 
            100                 105                 110         


Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly Phe Leu Lys Ser Leu 
        115                 120                 125             


Gly Val His Tyr Val Phe Asp Thr Thr Ile Ala Ala Asp Phe Ser Ile 
    130                 135                 140                 


Leu Glu Ser Gln Lys Glu Phe Val Arg Arg Tyr Arg Gln His Ser Glu 
145                 150                 155                 160 


Glu Glu Arg Thr Leu Pro Met Leu Thr Ser Ala Cys Pro Gly Trp Val 
                165                 170                 175     


Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile Thr Ala His Leu Cys 
            180                 185                 190         


Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser Leu Val Lys Asp Tyr 
        195                 200                 205             


Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys Ile Phe His Val Ile 
    210                 215                 220                 


Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala Leu Gln Glu Ser Leu 
225                 230                 235                 240 


Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp Cys Val Leu Thr Ser 
                245                 250                 255     


Gly Lys Val Leu Ile Ser Trp Trp Cys Thr Pro Val Ile Thr Ala Thr 
            260                 265                 270         


Gln Glu Ala Ala Ala Arg Glu Ser Leu Glu Pro Gly Arg Gln Arg Leu 
        275                 280                 285             


Gln Arg Asp Lys Ile Ala Pro Leu Asp Ser Ser Leu Gly Gly Gly Gly 
    290                 295                 300                 


Glu Ile Ala Gln Ile Met Glu Gln Gly Asp Leu Ser Val Arg Asp Ala 
305                 310                 315                 320 


Ala Val Asp Thr Leu Phe Gly Asp Leu Lys Glu Asp Lys Val Thr Arg 
                325                 330                 335     


His Asp Gly Ala Ser Ser Asp Gly His Leu Ala His Ile Phe Arg His 
            340                 345                 350         


Ala Ala Lys Glu Leu Phe Asn Glu Asp Val Glu Glu Val Thr Tyr Arg 
        355                 360                 365             


Ala Leu Arg Asn Lys Asp Phe Gln Glu Val Thr Leu Glu Lys Asn Gly 
    370                 375                 380                 


Glu Val Val Leu Arg Phe Ala Ala Ala Tyr Gly Phe Arg Asn Ile Gln 
385                 390                 395                 400 


Asn Met Ile Leu Lys Leu Lys Lys Gly Lys Phe Pro Phe His Phe Val 
                405                 410                 415     


Glu Val Leu Ala Cys Ala Gly Gly Cys Leu Asn Gly Arg Gly Gln Ala 
            420                 425                 430         


Gln Thr Pro Asp Gly His Ala Asp Lys Ala Leu Leu Arg Gln Met Glu 
        435                 440                 445             


Gly Ile Tyr Ala Asp Ile Pro Val Arg Arg Pro Glu Ser Ser Ala His 
    450                 455                 460                 


Val Gln Glu Leu Tyr Gln Glu Trp Leu Glu Gly Ile Asn Ser Pro Lys 
465                 470                 475                 480 


Ala Arg Glu Val Leu His Thr Thr Tyr Gln Ser Gln Glu Arg Gly Thr 
                485                 490                 495     


His Ser Leu Asp Ile Lys Trp 
            500             


<210> 6444
<211> 115
<212> PRT
<213> Homo sapiens

<400> 6444
Met Ala Thr Glu Pro Glu Ala Ala Glu Pro Val Val Pro Ser Leu Val 
1               5                   10                  15      


Asp Arg Tyr Phe Thr Arg Trp Tyr Lys Pro Asp Val Lys Gly Lys Phe 
            20                  25                  30          


Cys Glu Asp His Cys Ile Leu Gln His Ser Asn Arg Ile Cys Val Ile 
        35                  40                  45              


Thr Leu Ala Glu Ser His Pro Val Leu Gln Ser Gly Lys Thr Ile Lys 
    50                  55                  60                  


Ser Ile Ser Tyr Gln Ile Ser Thr Asn Cys Ser Arg Leu Gln Asn Lys 
65                  70                  75                  80  


Val Ser Gly Lys Phe Lys Arg Arg Ile Ile Tyr Leu Glu Lys Val Glu 
                85                  90                  95      


Asp Val Ile Lys Arg Lys Met Met Pro Leu Ser Leu Gly Leu His Leu 
            100                 105                 110         


Pro His Ser 
        115 


<210> 6445
<211> 521
<212> PRT
<213> Homo sapiens

<400> 6445
Met Asn Val Ser Leu Ser Gln Lys Thr Val Lys Ile His Arg Leu Phe 
1               5                   10                  15      


Pro Met Leu Ala Phe Ser Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp 
            20                  25                  30          


Leu Gln Lys Trp Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn 
        35                  40                  45              


His Ala Cys Leu Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser 
    50                  55                  60                  


Ile Met Lys Arg Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg 
65                  70                  75                  80  


Tyr Gly Gly Gly Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys 
                85                  90                  95      


Val Val Glu Arg Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu 
            100                 105                 110         


Asp Tyr Lys Thr Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Asp 
        115                 120                 125             


Gly Phe Trp Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala 
    130                 135                 140                 


Leu Glu Gln Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly 
145                 150                 155                 160 


Lys Met Asn Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg 
                165                 170                 175     


Lys Glu Glu Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His 
            180                 185                 190         


Gly Glu Leu Cys Ile Ser Glu Asn Glu Arg Arg Leu Val Ser Lys Glu 
        195                 200                 205             


Ala Trp Ser Lys Leu Gln Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro 
    210                 215                 220                 


Ser Tyr Lys Glu Cys Cys Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly 
225                 230                 235                 240 


Glu Glu Asn Glu Ala Leu His Lys Met Ile Ala Asn Glu Gln Lys Thr 
                245                 250                 255     


Ser Leu Pro Asn Leu Phe Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn 
            260                 265                 270         


Trp Pro Glu Asp Thr Asp Val Leu Tyr Ile Val Ser Gln Phe Phe Val 
        275                 280                 285             


Glu Glu Trp Arg Lys Phe Val Arg Lys Pro Thr Arg Cys Ser Pro Val 
    290                 295                 300                 


Ser Ser Val Gly Asn Ser Ala Leu Leu Cys Pro His Gly Gly Leu Met 
305                 310                 315                 320 


Phe Thr Phe Ala Ser Met Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu 
                325                 330                 335     


Ile Trp Pro Ser Glu Trp Gln Met Ile Gln Lys Leu Phe Val Val Asp 
            340                 345                 350         


His Val Ile Lys Ile Thr Arg Ile Glu Val Gly Asp Val Asn Pro Ser 
        355                 360                 365             


Glu Thr Gln Tyr Ile Ser Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu 
    370                 375                 380                 


Gly Leu Leu Cys Gln Gln Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala 
385                 390                 395                 400 


Thr Ile Tyr Val His Lys Val Val Asp Asn Lys Lys Val Met Lys Asp 
                405                 410                 415     


Ser Ala Pro Glu Leu Asn Val Ser Ser Ser Glu Thr Glu Glu Asp Lys 
            420                 425                 430         


Glu Glu Ala Lys Pro Asp Gly Glu Lys Asp Pro Asp Phe Asn Gln Ile 
        435                 440                 445             


Met His Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser Ile Asp 
    450                 455                 460                 


Gly Lys Ile Leu Ser Asp Asp Cys Ala Thr Leu Gly Thr Leu Gly Val 
465                 470                 475                 480 


Ile Pro Glu Ser Val Ile Leu Leu Lys Ala Asp Glu Pro Ile Ala Asp 
                485                 490                 495     


Tyr Ala Ala Met Asp Asp Val Met Gln Val Cys Met Pro Glu Glu Gly 
            500                 505                 510         


Phe Lys Gly Thr Gly Leu Leu Gly His 
        515                 520     


<210> 6446
<211> 327
<212> PRT
<213> Homo sapiens

<400> 6446
Met Thr Ala Val Gly Ala Glu Arg Leu Thr Ser Val Arg Ala Trp Leu 
1               5                   10                  15      


Ser Cys Cys Gly Ala Cys Val Cys Val Phe Leu Phe Leu Cys Leu Cys 
            20                  25                  30          


Val Phe Pro Leu Arg Val His Val His Val Trp Gly Gly Glu Cys Arg 
        35                  40                  45              


Val Asp Ile Ala Val Phe Val Ser Lys His Met Ile Val Ala Leu Met 
    50                  55                  60                  


His Val Thr Gly Ala Ala Gly Leu Leu Arg Leu Cys Val Arg Ala Cys 
65                  70                  75                  80  


Val Cys Met Arg Val Cys Ala Thr Ala His Met Tyr Arg Val Asp Lys 
                85                  90                  95      


Ser Phe Thr Ser Arg Arg Ser Val Trp Arg Ser Asp Gly Gln Asn Gln 
            100                 105                 110         


His Phe Pro Gln Ala Leu Asp Leu Ser Arg Val Asn Leu Val Pro Ser 
        115                 120                 125             


Tyr Thr Pro Ser Leu Tyr Pro Lys Asn Thr Asp Leu Phe Glu Met Ile 
    130                 135                 140                 


Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser Phe Pro 
145                 150                 155                 160 


Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser Val His 
                165                 170                 175     


Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu Pro Gln 
            180                 185                 190         


Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr Ser Ile 
        195                 200                 205             


Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys Leu Glu 
    210                 215                 220                 


Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly Lys Glu 
225                 230                 235                 240 


His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu Val Phe 
                245                 250                 255     


Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg Leu Leu 
            260                 265                 270         


Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile Ser Cys 
        275                 280                 285             


Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val Cys Glu 
    290                 295                 300                 


Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys Val Trp 
305                 310                 315                 320 


Leu Asp Leu Gly Thr Ala His 
                325         


<210> 6447
<211> 692
<212> PRT
<213> Homo sapiens

<400> 6447
Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
1               5                   10                  15      


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
            20                  25                  30          


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
        35                  40                  45              


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
    50                  55                  60                  


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
65                  70                  75                  80  


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
                85                  90                  95      


Lys Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu 
            100                 105                 110         


Val Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg 
        115                 120                 125             


Leu Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile 
    130                 135                 140                 


Ser Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val 
145                 150                 155                 160 


Cys Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys 
                165                 170                 175     


Ala Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn 
            180                 185                 190         


Phe Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu 
        195                 200                 205             


Glu Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu 
    210                 215                 220                 


Glu Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg 
225                 230                 235                 240 


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr 
                245                 250                 255     


Cys Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu 
            260                 265                 270         


Pro Tyr Thr Glu Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
        275                 280                 285             


Gly Asn Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe 
    290                 295                 300                 


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val 
305                 310                 315                 320 


Gln Ala Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val 
                325                 330                 335     


Thr Ala Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro 
            340                 345                 350         


Ala Val Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys 
        355                 360                 365             


Leu Ile Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys 
    370                 375                 380                 


Leu Glu Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu 
385                 390                 395                 400 


Leu His Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp 
                405                 410                 415     


Lys Met Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys 
            420                 425                 430         


Arg Val Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser 
        435                 440                 445             


Asn Lys Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala 
    450                 455                 460                 


Pro Asn Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Leu Ile 
465                 470                 475                 480 


Pro Gly Lys Ser Ala Ser Arg Phe Gly Arg Arg Gly Ser Ala Ile Gly 
                485                 490                 495     


Ile Gly Thr Val Glu Glu Val Val Val Arg Gly Ala Ala Gly Ser Gly 
            500                 505                 510         


Gly Cys Leu His Ala Leu Phe Ser Ala Arg Ser Gln Asp Gly Gly His 
        515                 520                 525             


Ile Gly Asp Val Ala Pro Leu Pro Pro Gly Gln Ala Pro Gly Arg Ala 
    530                 535                 540                 


Gly Trp Ser Gly Gly Ser Ser Asp Gly Thr Gln His Leu Leu Trp Gly 
545                 550                 555                 560 


Leu Ser Leu Ile Val Pro Gly Lys Ser Pro Thr Arg Lys Lys Ser Gly 
                565                 570                 575     


Pro Phe Gly Ser Arg Arg Ser Ser Ala Ile Gly Ile Glu Asn Ile Gln 
            580                 585                 590         


Glu Val Gln Glu Lys Arg Glu Ser Pro Pro Ala Gly Gln Lys Thr Pro 
        595                 600                 605             


Asp Ser Gly His Val Ser Gln Glu Pro Lys Ser Glu Asn Ser Ser Thr 
    610                 615                 620                 


Gln Ser Ser Pro Glu Met Pro Thr Thr Lys Asn Arg Ala Glu Thr Ala 
625                 630                 635                 640 


Ala Gln Arg Ala Glu Ala Leu Lys Leu Pro Leu Leu Val Gln Cys Gln 
                645                 650                 655     


Gln Leu Arg Gln Arg Gly Gly Gly Asp Gly Gly Cys Gly Arg Arg Gly 
            660                 665                 670         


His Arg Pro Gly Glu Arg Val Ile Leu Arg Asn Thr Pro Gln Ala Gly 
        675                 680                 685             


Leu Leu His Leu 
    690         


<210> 6448
<211> 694
<212> PRT
<213> Homo sapiens

<400> 6448
Met Ala Gln Leu Arg Pro Ala Val Pro Pro Gly Arg Pro Arg Arg Gly 
1               5                   10                  15      


Ser Leu Pro Ala Gly Ala Ser Trp Gln Asn Thr Asp Leu Phe Glu Met 
            20                  25                  30          


Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser Phe 
        35                  40                  45              


Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser Val 
    50                  55                  60                  


His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu Pro 
65                  70                  75                  80  


Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr Ser 
                85                  90                  95      


Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys Leu 
            100                 105                 110         


Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly Lys 
        115                 120                 125             


Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu Val 
    130                 135                 140                 


Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg Leu 
145                 150                 155                 160 


Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile Ser 
                165                 170                 175     


Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val Cys 
            180                 185                 190         


Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys Ala 
        195                 200                 205             


Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn Phe 
    210                 215                 220                 


Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu Glu 
225                 230                 235                 240 


Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu Glu 
                245                 250                 255     


Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg Gly 
            260                 265                 270         


Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr Cys 
        275                 280                 285             


Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu Pro 
    290                 295                 300                 


Tyr Thr Glu Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile Gly 
305                 310                 315                 320 


Asn Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe Val 
                325                 330                 335     


Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val Gln 
            340                 345                 350         


Ala Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val Thr 
        355                 360                 365             


Ala Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro Ala 
    370                 375                 380                 


Val Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys Leu 
385                 390                 395                 400 


Ile Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys Leu 
                405                 410                 415     


Glu Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu Leu 
            420                 425                 430         


His Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp Lys 
        435                 440                 445             


Met Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys Arg 
    450                 455                 460                 


Val Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser Asn 
465                 470                 475                 480 


Lys Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala Pro 
                485                 490                 495     


Asn Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Ile Val Pro 
            500                 505                 510         


Gly Lys Ser Pro Thr Arg Lys Lys Ser Gly Pro Phe Gly Ser Arg Arg 
        515                 520                 525             


Ser Ser Ala Ile Gly Ile Glu Asn Ile Gln Glu Val Gln Glu Lys Arg 
    530                 535                 540                 


Glu Ser Pro Pro Ala Gly Gln Lys Thr Pro Asp Ser Gly His Val Ser 
545                 550                 555                 560 


Gln Glu Pro Lys Ser Glu Asn Ser Ser Thr Gln Ser Ser Pro Glu Met 
                565                 570                 575     


Pro Thr Thr Lys Asn Arg Ala Glu Thr Ala Ala Gln Arg Ala Glu Ala 
            580                 585                 590         


Leu Lys Asp Phe Ser Arg Ser Ser Ser Ser Ala Ser Ser Phe Ala Ser 
        595                 600                 605             


Val Val Glu Glu Thr Glu Gly Val Asp Gly Glu Asp Thr Gly Leu Glu 
    610                 615                 620                 


Ser Val Ser Ser Ser Gly Thr Pro His Lys Arg Asp Ser Phe Ile Tyr 
625                 630                 635                 640 


Ser Thr Trp Leu Glu Asp Ser Val Ser Thr Thr Ser Gly Gly Ser Ser 
                645                 650                 655     


Pro Gly Pro Ser Arg Ser Pro His Pro Asp Ala Gly Lys Leu Gly Asp 
            660                 665                 670         


Pro Ala Cys Pro Glu Ile Lys Ile Gln Leu Glu Ala Ser Glu Gln His 
        675                 680                 685             


Met Pro Gln Leu Gly Cys 
    690                 


<210> 6449
<211> 693
<212> PRT
<213> Homo sapiens

<400> 6449
Met Ala Gln Leu Arg Pro Ala Val Pro Pro Gly Arg Pro Arg Arg Gly 
1               5                   10                  15      


Ser Leu Pro Ala Gly Ala Ser Trp Gln Asn Thr Asp Leu Phe Glu Met 
            20                  25                  30          


Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser Phe 
        35                  40                  45              


Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser Val 
    50                  55                  60                  


His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu Pro 
65                  70                  75                  80  


Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr Ser 
                85                  90                  95      


Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys Leu 
            100                 105                 110         


Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly Lys 
        115                 120                 125             


Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu Val 
    130                 135                 140                 


Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg Leu 
145                 150                 155                 160 


Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile Ser 
                165                 170                 175     


Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val Cys 
            180                 185                 190         


Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys Ala 
        195                 200                 205             


Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn Phe 
    210                 215                 220                 


Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu Glu 
225                 230                 235                 240 


Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu Glu 
                245                 250                 255     


Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg Gly 
            260                 265                 270         


Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr Cys 
        275                 280                 285             


Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu Pro 
    290                 295                 300                 


Tyr Thr Glu Gly Asp Ala Gln Leu Gln Arg Lys Arg His Ile Gly Asn 
305                 310                 315                 320 


Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe Val Pro 
                325                 330                 335     


Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val Gln Ala 
            340                 345                 350         


Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val Thr Ala 
        355                 360                 365             


Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro Ala Val 
    370                 375                 380                 


Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys Leu Ile 
385                 390                 395                 400 


Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys Leu Glu 
                405                 410                 415     


Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu Leu His 
            420                 425                 430         


Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp Lys Met 
        435                 440                 445             


Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys Arg Val 
    450                 455                 460                 


Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser Asn Lys 
465                 470                 475                 480 


Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala Pro Asn 
                485                 490                 495     


Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Ile Val Pro Gly 
            500                 505                 510         


Lys Ser Pro Thr Arg Lys Lys Ser Gly Pro Phe Gly Ser Arg Arg Ser 
        515                 520                 525             


Ser Ala Ile Gly Ile Glu Asn Ile Gln Glu Val Gln Glu Lys Arg Glu 
    530                 535                 540                 


Ser Pro Pro Ala Gly Gln Lys Thr Pro Asp Ser Gly His Val Ser Gln 
545                 550                 555                 560 


Glu Pro Lys Ser Glu Asn Ser Ser Thr Gln Ser Ser Pro Glu Met Pro 
                565                 570                 575     


Thr Thr Lys Asn Arg Ala Glu Thr Ala Ala Gln Arg Ala Glu Ala Leu 
            580                 585                 590         


Lys Asp Phe Ser Arg Ser Ser Ser Ser Ala Ser Ser Phe Ala Ser Val 
        595                 600                 605             


Val Glu Glu Thr Glu Gly Val Asp Gly Glu Asp Thr Gly Leu Glu Ser 
    610                 615                 620                 


Val Ser Ser Ser Gly Thr Pro His Lys Arg Asp Ser Phe Ile Tyr Ser 
625                 630                 635                 640 


Thr Trp Leu Glu Asp Ser Val Ser Thr Thr Ser Gly Gly Ser Ser Pro 
                645                 650                 655     


Gly Pro Ser Arg Ser Pro His Pro Asp Ala Gly Lys Leu Gly Asp Pro 
            660                 665                 670         


Ala Cys Pro Glu Ile Lys Ile Gln Leu Glu Ala Ser Glu Gln His Met 
        675                 680                 685             


Pro Gln Leu Gly Cys 
    690             


<210> 6450
<211> 663
<212> PRT
<213> Homo sapiens

<400> 6450
Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
1               5                   10                  15      


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
            20                  25                  30          


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
        35                  40                  45              


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
    50                  55                  60                  


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
65                  70                  75                  80  


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
                85                  90                  95      


Lys Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu 
            100                 105                 110         


Val Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg 
        115                 120                 125             


Leu Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile 
    130                 135                 140                 


Ser Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val 
145                 150                 155                 160 


Cys Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys 
                165                 170                 175     


Ala Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn 
            180                 185                 190         


Phe Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu 
        195                 200                 205             


Glu Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu 
    210                 215                 220                 


Glu Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg 
225                 230                 235                 240 


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr 
                245                 250                 255     


Cys Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu 
            260                 265                 270         


Pro Tyr Thr Glu Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
        275                 280                 285             


Gly Asn Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe 
    290                 295                 300                 


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val 
305                 310                 315                 320 


Gln Ala Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val 
                325                 330                 335     


Thr Ala Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro 
            340                 345                 350         


Ala Val Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys 
        355                 360                 365             


Leu Ile Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys 
    370                 375                 380                 


Leu Glu Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu 
385                 390                 395                 400 


Leu His Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp 
                405                 410                 415     


Lys Met Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys 
            420                 425                 430         


Arg Val Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser 
        435                 440                 445             


Asn Lys Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala 
    450                 455                 460                 


Pro Asn Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Ile Val 
465                 470                 475                 480 


Pro Gly Lys Ser Pro Thr Arg Lys Lys Ser Gly Pro Phe Gly Ser Arg 
                485                 490                 495     


Arg Ser Ser Ala Ile Gly Ile Glu Asn Ile Gln Glu Val Gln Glu Lys 
            500                 505                 510         


Arg Glu Ser Pro Pro Ala Gly Gln Lys Thr Pro Asp Ser Gly His Val 
        515                 520                 525             


Ser Gln Glu Pro Lys Ser Glu Asn Ser Ser Thr Gln Ser Ser Pro Glu 
    530                 535                 540                 


Met Pro Thr Thr Lys Asn Arg Ala Glu Thr Ala Ala Gln Arg Ala Glu 
545                 550                 555                 560 


Ala Leu Lys Asp Phe Ser Arg Ser Ser Ser Ser Ala Ser Ser Phe Ala 
                565                 570                 575     


Ser Val Val Glu Glu Thr Glu Gly Val Asp Gly Glu Asp Thr Gly Leu 
            580                 585                 590         


Glu Ser Val Ser Ser Ser Gly Thr Pro His Lys Arg Asp Ser Phe Ile 
        595                 600                 605             


Tyr Ser Thr Trp Leu Glu Asp Ser Val Ser Thr Thr Ser Gly Gly Ser 
    610                 615                 620                 


Ser Pro Gly Pro Ser Arg Ser Pro His Pro Asp Ala Gly Lys Leu Gly 
625                 630                 635                 640 


Asp Pro Ala Cys Pro Glu Ile Lys Ile Gln Leu Glu Ala Ser Glu Gln 
                645                 650                 655     


His Met Pro Gln Leu Gly Cys 
            660             


<210> 6451
<211> 247
<212> PRT
<213> Homo sapiens

<400> 6451
Met Leu Val Leu Arg Ser Ala Leu Thr Arg Ala Leu Ala Ser Arg Thr 
1               5                   10                  15      


Leu Ala Pro Gln Met Cys Ser Ser Phe Ala Thr Gly Pro Arg Gln Tyr 
            20                  25                  30          


Asp Gly Ile Phe Tyr Glu Phe Arg Ser Tyr Tyr Leu Lys Pro Ser Lys 
        35                  40                  45              


Met Asn Glu Phe Leu Glu Asn Phe Glu Lys Asn Ala His Leu Arg Thr 
    50                  55                  60                  


Ala His Ser Glu Leu Val Gly Tyr Trp Ser Val Glu Phe Gly Gly Arg 
65                  70                  75                  80  


Met Asn Thr Val Phe His Ile Trp Lys Tyr Asp Asn Phe Ala His Arg 
                85                  90                  95      


Thr Glu Val Arg Lys Ala Leu Ala Lys Asp Lys Glu Trp Gln Glu Gln 
            100                 105                 110         


Phe Leu Ile Pro Asn Leu Ala Leu Ile Asp Lys Gln Glu Ser Glu Ile 
        115                 120                 125             


Thr Tyr Leu Val Pro Trp Cys Lys Leu Glu Lys Pro Pro Lys Glu Gly 
    130                 135                 140                 


Val Tyr Glu Leu Ala Thr Phe Gln Met Lys Pro Gly Gly Pro Ala Leu 
145                 150                 155                 160 


Trp Gly Asp Ala Phe Lys Arg Ala Val His Ala His Val Asn Leu Gly 
                165                 170                 175     


Tyr Thr Lys Leu Val Gly Val Phe His Thr Glu Tyr Gly Ala Leu Asn 
            180                 185                 190         


Arg Val His Val Leu Trp Trp Asn Glu Ser Ala Asp Ser Arg Ala Ala 
        195                 200                 205             


Gly Arg His Lys Ser His Glu Asp Pro Arg Val Val Ala Ala Val Arg 
    210                 215                 220                 


Glu Ser Val Asn Tyr Leu Val Ser Gln Gln Asn Met Leu Leu Ile Pro 
225                 230                 235                 240 


Thr Ser Phe Ser Pro Leu Lys 
                245         


<210> 6452
<211> 1197
<212> PRT
<213> Homo sapiens

<400> 6452
Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln 
1               5                   10                  15      


Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly 
            20                  25                  30          


Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu 
        35                  40                  45              


Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser 
65                  70                  75                  80  


Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu 
                85                  90                  95      


Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg 
            100                 105                 110         


Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln 
        115                 120                 125             


Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu 
    130                 135                 140                 


Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu 
145                 150                 155                 160 


Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr 
                165                 170                 175     


Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu 
            180                 185                 190         


Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln 
        195                 200                 205             


Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met 
    210                 215                 220                 


Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met 
                245                 250                 255     


Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys 
            260                 265                 270         


Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys 
        275                 280                 285             


Asp Lys Glu Thr Gly Gly Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala 
    290                 295                 300                 


Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys 
                325                 330                 335     


Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Val 
            340                 345                 350         


Lys Lys Ile Thr Asp Gly Leu His Ala Leu Gln Glu Ala Ser Asn Lys 
        355                 360                 365             


Asp Ala Glu Ala Leu Ala Ala Ala Gln Gln His Phe Asn Ala Val Ser 
    370                 375                 380                 


Ala Gly Leu Ser Ser Asn Glu Asp Gly Ala Glu Ala Thr Leu Ala Gly 
385                 390                 395                 400 


Gln Met Met Ala Cys Lys Asn Asp Ile Ser Lys Ala Gln Thr Glu Ala 
                405                 410                 415     


Lys Gln Ala Gln Met Lys Leu Lys His Ala Gln Gln Glu Leu Lys Asn 
            420                 425                 430         


Lys Gln Ala Glu Val Lys Lys Met Asp Ser Gly Tyr Arg Lys Asp Gln 
        435                 440                 445             


Glu Ala Leu Glu Ala Val Lys Arg Leu Lys Glu Lys Leu Glu Ala Glu 
    450                 455                 460                 


Met Lys Lys Leu Asn Tyr Glu Glu Asn Lys Glu Glu Ser Leu Leu Glu 
465                 470                 475                 480 


Lys Arg Arg Gln Leu Ser Arg Asp Ile Gly Arg Leu Lys Glu Thr Tyr 
                485                 490                 495     


Glu Ala Leu Leu Ala Arg Phe Pro Asn Leu Arg Phe Ala Tyr Lys Asp 
            500                 505                 510         


Pro Glu Lys Asn Trp Asn Arg Asn Cys Val Lys Gly Leu Val Ala Ser 
        515                 520                 525             


Leu Ile Ser Val Lys Asp Thr Ser Ala Thr Thr Ala Leu Glu Leu Val 
    530                 535                 540                 


Ala Gly Glu Arg Leu Tyr Asn Val Val Val Asp Thr Glu Val Thr Gly 
545                 550                 555                 560 


Lys Lys Leu Leu Glu Arg Gly Glu Leu Lys Arg Arg Tyr Thr Ile Ile 
                565                 570                 575     


Pro Leu Asn Lys Ile Ser Ala Arg Cys Ile Ala Pro Glu Thr Leu Arg 
            580                 585                 590         


Val Ala Gln Asn Leu Val Gly Pro Asp Asn Val His Val Ala Leu Ser 
        595                 600                 605             


Leu Val Glu Tyr Lys Pro Glu Leu Gln Lys Ala Met Glu Phe Val Phe 
    610                 615                 620                 


Gly Thr Thr Phe Val Cys Asp Asn Met Asp Asn Ala Lys Lys Val Ala 
625                 630                 635                 640 


Phe Asp Lys Arg Ile Met Thr Arg Thr Val Thr Leu Gly Gly Asp Val 
                645                 650                 655     


Phe Asp Pro His Gly Thr Leu Ser Gly Gly Ala Arg Ser Gln Ala Ala 
            660                 665                 670         


Ser Ile Leu Thr Lys Phe Gln Glu Leu Lys Asp Val Gln Asp Glu Leu 
        675                 680                 685             


Arg Ile Lys Glu Asn Glu Leu Arg Ala Leu Glu Glu Glu Leu Ala Gly 
    690                 695                 700                 


Leu Lys Asn Thr Ala Glu Lys Tyr Arg Gln Leu Lys Gln Gln Trp Glu 
705                 710                 715                 720 


Met Lys Thr Glu Glu Ala Asp Leu Leu Gln Thr Lys Leu Gln Gln Ser 
                725                 730                 735     


Ser Tyr His Lys Gln Gln Glu Glu Leu Asp Ala Leu Lys Lys Thr Ile 
            740                 745                 750         


Glu Glu Ser Glu Glu Thr Leu Lys Asn Thr Lys Glu Ile Gln Arg Lys 
        755                 760                 765             


Ala Glu Glu Lys Tyr Glu Val Leu Glu Asn Lys Met Lys Asn Ala Glu 
    770                 775                 780                 


Ala Glu Arg Glu Arg Glu Leu Lys Asp Ala Gln Lys Lys Leu Asp Cys 
785                 790                 795                 800 


Ala Lys Thr Lys Ala Asp Ala Ser Ser Lys Lys Met Lys Glu Lys Gln 
                805                 810                 815     


Gln Glu Val Glu Ala Ile Thr Leu Glu Leu Glu Glu Leu Lys Arg Glu 
            820                 825                 830         


His Thr Ser Tyr Lys Gln Gln Leu Glu Ala Val Asn Glu Ala Ile Lys 
        835                 840                 845             


Ser Tyr Glu Ser Gln Ile Glu Val Met Ala Ala Glu Val Ala Lys Asn 
    850                 855                 860                 


Lys Glu Ser Val Asn Lys Ala Gln Glu Glu Val Thr Lys Gln Lys Glu 
865                 870                 875                 880 


Val Ile Thr Ala Gln Asp Thr Val Ile Lys Ala Lys Tyr Ala Glu Val 
                885                 890                 895     


Ala Lys His Lys Glu Gln Asn Asn Asp Ser Gln Leu Lys Ile Lys Glu 
            900                 905                 910         


Leu Asp His Asn Ile Ser Lys His Lys Arg Glu Ala Glu Asp Gly Ala 
        915                 920                 925             


Ala Lys Val Ser Lys Met Leu Lys Asp Tyr Asp Trp Ile Asn Ala Glu 
    930                 935                 940                 


Arg His Leu Phe Gly Gln Pro Asn Ser Ala Tyr Asp Phe Lys Thr Asn 
945                 950                 955                 960 


Asn Pro Lys Glu Ala Gly Gln Arg Leu Gln Lys Leu Gln Glu Met Lys 
                965                 970                 975     


Glu Lys Leu Gly Arg Asn Val Asn Met Arg Ala Met Asn Val Leu Thr 
            980                 985                 990         


Glu Ala Glu Glu Arg Tyr Asn Asp  Leu Met Lys Lys Lys  Arg Ile Val 
        995                 1000                 1005             


Glu Asn  Asp Lys Ser Lys Ile  Leu Thr Thr Ile Glu  Asp Leu Asp 
    1010                 1015                 1020             


Gln Lys  Lys Asn Gln Ala Leu  Asn Ile Ala Trp Gln  Lys Val Asn 
    1025                 1030                 1035             


Lys Asp  Phe Gly Ser Ile Phe  Ser Thr Leu Leu Pro  Gly Ala Asn 
    1040                 1045                 1050             


Ala Met  Leu Ala Pro Pro Glu  Gly Gln Thr Val Leu  Asp Gly Leu 
    1055                 1060                 1065             


Glu Phe  Lys Val Ala Leu Gly  Asn Thr Trp Lys Glu  Asn Leu Thr 
    1070                 1075                 1080             


Glu Leu  Ser Gly Gly Gln Arg  Ser Leu Val Ala Leu  Ser Leu Ile 
    1085                 1090                 1095             


Leu Ser  Met Leu Leu Phe Lys  Pro Ala Pro Ile Tyr  Ile Leu Asp 
    1100                 1105                 1110             


Glu Val  Asp Ala Ala Leu Asp  Leu Ser His Thr Gln  Asn Ile Gly 
    1115                 1120                 1125             


Gln Met  Leu Arg Thr His Phe  Thr His Ser Gln Phe  Ile Val Val 
    1130                 1135                 1140             


Ser Leu  Lys Glu Gly Met Phe  Asn Asn Ala Asn Val  Leu Phe Lys 
    1145                 1150                 1155             


Thr Lys  Phe Val Asp Gly Val  Ser Thr Val Ala Arg  Phe Thr Gln 
    1160                 1165                 1170             


Cys Gln  Asn Gly Lys Ile Ser  Lys Glu Ala Lys Ser  Lys Ala Lys 
    1175                 1180                 1185             


Pro Pro  Lys Gly Ala His Val  Glu Val 
    1190                 1195         


<210> 6453
<211> 1197
<212> PRT
<213> Homo sapiens

<400> 6453
Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln 
1               5                   10                  15      


Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly 
            20                  25                  30          


Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu 
        35                  40                  45              


Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser 
65                  70                  75                  80  


Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu 
                85                  90                  95      


Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg 
            100                 105                 110         


Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln 
        115                 120                 125             


Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu 
    130                 135                 140                 


Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu 
145                 150                 155                 160 


Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr 
                165                 170                 175     


Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu 
            180                 185                 190         


Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln 
        195                 200                 205             


Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met 
    210                 215                 220                 


Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met 
                245                 250                 255     


Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys 
            260                 265                 270         


Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys 
        275                 280                 285             


Asp Lys Glu Thr Gly Gly Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala 
    290                 295                 300                 


Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys 
                325                 330                 335     


Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Val 
            340                 345                 350         


Lys Lys Ile Thr Asp Gly Leu His Ala Leu Gln Glu Ala Ser Asn Lys 
        355                 360                 365             


Asp Ala Glu Ala Leu Ala Ala Ala Gln Gln His Phe Asn Ala Val Ser 
    370                 375                 380                 


Ala Gly Leu Ser Ser Asn Glu Asp Gly Ala Glu Ala Thr Leu Ala Gly 
385                 390                 395                 400 


Gln Met Met Ala Cys Lys Asn Asp Ile Ser Lys Ala Gln Thr Glu Ala 
                405                 410                 415     


Lys Gln Ala Gln Met Lys Leu Lys His Ala Gln Gln Glu Leu Lys Asn 
            420                 425                 430         


Lys Gln Ala Glu Val Lys Lys Met Asp Ser Gly Tyr Arg Lys Asp Gln 
        435                 440                 445             


Glu Ala Leu Glu Ala Val Lys Arg Leu Lys Glu Lys Leu Glu Ala Glu 
    450                 455                 460                 


Met Lys Lys Leu Asn Tyr Glu Glu Asn Lys Glu Glu Ser Leu Leu Glu 
465                 470                 475                 480 


Lys Arg Arg Gln Leu Ser Arg Asp Ile Gly Arg Leu Lys Glu Thr Tyr 
                485                 490                 495     


Glu Ala Leu Leu Ala Arg Phe Pro Asn Leu Arg Phe Ala Tyr Lys Asp 
            500                 505                 510         


Pro Glu Lys Asn Trp Asn Arg Asn Cys Val Lys Gly Leu Val Ala Ser 
        515                 520                 525             


Leu Ile Ser Val Lys Asp Thr Ser Ala Thr Thr Ala Leu Glu Leu Val 
    530                 535                 540                 


Ala Gly Glu Arg Leu Tyr Asn Val Val Val Asp Thr Glu Val Thr Gly 
545                 550                 555                 560 


Lys Lys Leu Leu Glu Arg Gly Glu Leu Lys Arg Arg Tyr Thr Ile Ile 
                565                 570                 575     


Pro Leu Asn Lys Ile Ser Ala Arg Cys Ile Ala Pro Glu Thr Leu Arg 
            580                 585                 590         


Val Ala Gln Asn Leu Val Gly Pro Asp Asn Val His Val Ala Leu Ser 
        595                 600                 605             


Leu Val Glu Tyr Lys Pro Glu Leu Gln Lys Ala Met Glu Phe Val Phe 
    610                 615                 620                 


Gly Thr Thr Phe Val Cys Asp Asn Met Asp Asn Ala Lys Lys Val Ala 
625                 630                 635                 640 


Phe Asp Lys Arg Ile Met Thr Arg Thr Val Thr Leu Gly Gly Asp Val 
                645                 650                 655     


Phe Asp Pro His Gly Thr Leu Ser Gly Gly Ala Arg Ser Gln Ala Ala 
            660                 665                 670         


Ser Ile Leu Thr Lys Phe Gln Glu Leu Lys Asp Val Gln Asp Glu Leu 
        675                 680                 685             


Arg Ile Lys Glu Asn Glu Leu Arg Ala Leu Glu Glu Glu Leu Ala Gly 
    690                 695                 700                 


Leu Lys Asn Thr Ala Glu Lys Tyr Arg Gln Leu Lys Gln Gln Trp Glu 
705                 710                 715                 720 


Met Lys Thr Glu Glu Ala Asp Leu Leu Gln Thr Lys Leu Gln Gln Ser 
                725                 730                 735     


Ser Tyr His Lys Gln Gln Glu Glu Leu Asp Ala Leu Lys Lys Thr Ile 
            740                 745                 750         


Glu Glu Ser Glu Glu Thr Leu Lys Asn Thr Lys Glu Ile Gln Arg Lys 
        755                 760                 765             


Ala Glu Glu Lys Tyr Glu Val Leu Glu Asn Lys Met Lys Asn Ala Glu 
    770                 775                 780                 


Ala Glu Arg Glu Arg Glu Leu Lys Asp Ala Gln Lys Lys Leu Asp Cys 
785                 790                 795                 800 


Ala Lys Thr Lys Ala Asp Ala Ser Ser Lys Lys Met Lys Glu Lys Gln 
                805                 810                 815     


Gln Glu Val Glu Ala Ile Thr Leu Glu Leu Glu Glu Leu Lys Arg Glu 
            820                 825                 830         


His Thr Ser Tyr Lys Gln Gln Leu Glu Ala Val Asn Glu Ala Ile Lys 
        835                 840                 845             


Ser Tyr Glu Ser Gln Ile Glu Val Met Ala Ala Glu Val Ala Lys Asn 
    850                 855                 860                 


Lys Glu Ser Val Asn Lys Ala Gln Glu Glu Val Thr Lys Gln Lys Glu 
865                 870                 875                 880 


Val Ile Thr Ala Gln Asp Thr Val Ile Lys Ala Lys Tyr Ala Glu Val 
                885                 890                 895     


Ala Lys His Lys Glu Gln Asn Asn Asp Ser Gln Leu Lys Ile Lys Glu 
            900                 905                 910         


Leu Asp His Asn Ile Ser Lys His Lys Arg Glu Ala Glu Asp Gly Ala 
        915                 920                 925             


Ala Lys Val Ser Lys Met Leu Lys Asp Tyr Asp Trp Ile Asn Ala Glu 
    930                 935                 940                 


Arg His Leu Phe Gly Gln Pro Asn Ser Ala Tyr Asp Phe Lys Thr Asn 
945                 950                 955                 960 


Asn Pro Lys Glu Ala Gly Gln Arg Leu Gln Lys Leu Gln Glu Met Lys 
                965                 970                 975     


Glu Lys Leu Gly Arg Asn Val Asn Met Arg Ala Met Asn Val Leu Thr 
            980                 985                 990         


Glu Ala Glu Glu Arg Tyr Asn Asp  Leu Met Lys Lys Lys  Arg Ile Val 
        995                 1000                 1005             


Glu Asn  Asp Lys Ser Lys Ile  Leu Thr Thr Ile Glu  Asp Leu Asp 
    1010                 1015                 1020             


Gln Lys  Lys Asn Gln Ala Leu  Asn Ile Ala Trp Gln  Lys Val Asn 
    1025                 1030                 1035             


Lys Asp  Phe Gly Ser Ile Phe  Ser Thr Leu Leu Pro  Gly Ala Asn 
    1040                 1045                 1050             


Ala Met  Leu Ala Pro Pro Glu  Gly Gln Thr Val Leu  Asp Gly Leu 
    1055                 1060                 1065             


Glu Phe  Lys Val Ala Leu Gly  Asn Thr Trp Lys Glu  Asn Leu Thr 
    1070                 1075                 1080             


Glu Leu  Ser Gly Gly Gln Arg  Ser Leu Val Ala Leu  Ser Leu Ile 
    1085                 1090                 1095             


Leu Ser  Met Leu Leu Phe Lys  Pro Ala Pro Ile Tyr  Ile Leu Asp 
    1100                 1105                 1110             


Glu Val  Asp Ala Ala Leu Asp  Leu Ser His Thr Gln  Asn Ile Gly 
    1115                 1120                 1125             


Gln Met  Leu Arg Thr His Phe  Thr His Ser Gln Phe  Ile Val Val 
    1130                 1135                 1140             


Ser Leu  Lys Glu Gly Met Phe  Asn Asn Ala Asn Val  Leu Phe Lys 
    1145                 1150                 1155             


Thr Lys  Phe Val Asp Gly Val  Ser Thr Val Ala Arg  Phe Thr Gln 
    1160                 1165                 1170             


Cys Gln  Asn Gly Lys Ile Ser  Lys Glu Ala Lys Ser  Lys Ala Lys 
    1175                 1180                 1185             


Pro Pro  Lys Gly Ala His Val  Glu Val 
    1190                 1195         


<210> 6454
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6454
Met Ser Leu Pro Arg Phe Gln Arg Val Asn Phe Gly Pro Tyr Asp Asn 
1               5                   10                  15      


Tyr Ile Pro Val Ser Glu Leu Ser Lys Lys Ser Trp Asn Gln Gln His 
            20                  25                  30          


Phe Ala Leu Leu Phe Pro Lys Pro Gln Arg Pro Gly Thr Lys Arg Arg 
        35                  40                  45              


Ser Lys Pro Ser Gln Ile Arg Asp Asn Thr Val Ser Ile Ile Asp Glu 
    50                  55                  60                  


Glu Gln Leu Arg Gly Asp Arg Arg Gln Pro Leu Trp Met Tyr Arg Ser 
65                  70                  75                  80  


Leu Met Arg Ile Ser Glu Arg Pro Ser Val Tyr Leu Ala Ala Arg Arg 
                85                  90                  95      


Gln Pro Leu Lys Pro Thr Arg Thr Val Glu Val Asp Ser Lys Ala Ala 
            100                 105                 110         


Glu Ile Gly Lys Lys Gly Glu Asp Lys Thr Thr Gln Lys Asp Thr Thr 
        115                 120                 125             


Asp Ser Glu Ser Glu Leu Lys Gln Gly Lys Lys Asp Ser Lys Lys Gly 
    130                 135                 140                 


Lys Asp Ile Glu Lys Gly Lys Glu Glu Lys Leu Asp Ala Lys Lys Asp 
145                 150                 155                 160 


Ser Lys Lys Gly Lys Lys Asp Ala Glu Lys Gly Lys Asp Ser Ala Thr 
                165                 170                 175     


Glu Ser Glu Asp Glu Lys Gly Gly Ala Lys Lys Asp Asn Lys Lys Asp 
            180                 185                 190         


Lys Lys Asp Ser Asn Lys Gly Lys Asp Ser Ala Thr Glu Ser Glu Gly 
        195                 200                 205             


Glu Lys Gly Gly Thr Glu Lys Asp Ser Lys Lys Gly Lys Lys Asp Ser 
    210                 215                 220                 


Lys Lys Gly Lys Asp Ser Ala Ile Glu Leu Gln Ala Val Lys Ala Asp 
225                 230                 235                 240 


Glu Lys Lys Asp Glu Asp Gly Lys Lys Asp Ala Asn Lys Gly Asp Glu 
                245                 250                 255     


Ser Lys Asp Ala Lys Lys Asp Ala Lys Glu Ile Lys Lys Gly Lys Lys 
            260                 265                 270         


Asp Lys Lys Lys Pro Ser Ser Thr Asp Ser Asp Ser Lys Asp Asp Val 
        275                 280                 285             


Lys Lys Glu Ser Lys Lys Asp Ala Thr Lys Asp Ala Lys Lys Val Ala 
    290                 295                 300                 


Lys Lys Asp Thr Glu Lys Glu Ser Ala Asp Ser Lys Lys Asp Ala Lys 
305                 310                 315                 320 


Lys Asn Ala Lys Lys Asp Ala Lys Lys Asp Ala Lys Lys Asn Ala Lys 
                325                 330                 335     


Lys Asp Glu Lys Lys Asp Ala Lys Lys Lys Gly Lys 
            340                 345             


<210> 6455
<211> 504
<212> PRT
<213> Homo sapiens

<400> 6455
Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Phe Gln Arg Pro Gln 
1               5                   10                  15      


Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg 
            20                  25                  30          


Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile 
        35                  40                  45              


Met Met Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro 
    50                  55                  60                  


Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly 
65                  70                  75                  80  


Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr 
                85                  90                  95      


Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe 
            100                 105                 110         


Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr 
        115                 120                 125             


Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile 
    130                 135                 140                 


Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser 
                165                 170                 175     


Thr Pro Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser 
            180                 185                 190         


Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr 
        195                 200                 205             


Pro Val Thr Ala Ala Ser Asp Gln Lys Gln Glu Glu Lys Pro Lys Pro 
    210                 215                 220                 


Asp Pro Val Leu Lys Ser Pro Ser Pro Val Leu Arg Leu Val Leu Ser 
225                 230                 235                 240 


Gly Glu Lys Lys Glu Gln Glu Gly Gln Thr Ser Glu Thr Thr Ala Ile 
                245                 250                 255     


Val Ser Ile Ala Glu Leu Pro Leu Pro Pro Ser Pro Thr Thr Val Ser 
            260                 265                 270         


Ser Val Ala Arg Ser Thr Ile Ala Ala Pro Thr Ser Ser Ala Leu Ser 
        275                 280                 285             


Ser Gln Pro Ile Phe Thr Thr Ala Ile Asp Asp Arg Cys Glu Leu Ser 
    290                 295                 300                 


Ser Pro Arg Glu Asp Thr Ile Pro Ile Pro Ser Leu Thr Ser Cys Thr 
305                 310                 315                 320 


Glu Thr Ser Asp Pro Leu Pro Thr Asn Glu Asn Asp Asp Asp Ile Cys 
                325                 330                 335     


Lys Lys Pro Cys Ser Val Ala Pro Asn Asp Ile Pro Leu Val Ser Ser 
            340                 345                 350         


Thr Asn Leu Ile Asn Glu Ile Asn Gly Val Ser Glu Lys Leu Ser Ala 
        355                 360                 365             


Thr Glu Ser Ile Val Glu Ile Val Lys Gln Glu Val Leu Pro Leu Thr 
    370                 375                 380                 


Leu Glu Leu Glu Ile Leu Glu Asn Pro Pro Glu Glu Met Lys Leu Glu 
385                 390                 395                 400 


Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr Val Pro Ser Phe Pro Pro 
                405                 410                 415     


Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro His Thr Pro Val Ile Val 
            420                 425                 430         


Pro Ala Ala Ala Thr Thr Val Ser Ser Pro Ser Ala Ala Ile Thr Val 
        435                 440                 445             


Gln Arg Val Leu Glu Glu Asp Glu Ser Ile Arg Thr Cys Leu Ser Glu 
    450                 455                 460                 


Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu Val Glu Ala Asp Gly Gln 
465                 470                 475                 480 


Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser Arg Arg Ser Pro 
                485                 490                 495     


Val Pro Glu Thr Ser Asn Glu Cys 
            500                 


<210> 6456
<211> 247
<212> PRT
<213> Homo sapiens

<400> 6456
Met Leu Lys Phe Leu Val Trp Phe Leu Gln Trp Cys Val Cys Val Leu 
1               5                   10                  15      


Val Gln Pro Ala Lys Glu Leu Leu His Cys Leu Lys Met Gln Met Arg 
            20                  25                  30          


Ile Ser Lys Tyr Thr Lys Cys Leu Gln Ala Gln Ile Ala Ile Thr Val 
        35                  40                  45              


Pro Lys Thr Trp Lys Lys Pro Lys Asp Arg Thr Arg Thr Thr Glu Glu 
    50                  55                  60                  


Met Leu Glu Ala Glu Leu Glu Leu Lys Ala Glu Glu Glu Leu Ser Ile 
65                  70                  75                  80  


Asp Lys Val Leu Glu Ser Glu Gln Asp Lys Met Ser Gln Gly Phe His 
                85                  90                  95      


Pro Glu Arg Asp Pro Ser Asp Leu Lys Lys Val Lys Ala Val Glu Glu 
            100                 105                 110         


Asn Gly Glu Glu Ala Glu Pro Val Arg Asn Gly Ala Glu Ser Val Ser 
        115                 120                 125             


Glu Gly Glu Gly Ile Asp Ala Asn Ser Gly Ser Thr Asp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Val Thr Phe Pro Phe Lys Pro Glu Ser Trp Lys Pro Thr Asp 
145                 150                 155                 160 


Thr Glu Gly Lys Lys Gln Tyr Asp Arg Glu Phe Leu Leu Asp Phe Gln 
                165                 170                 175     


Phe Met Pro Ala Cys Ile Gln Lys Pro Glu Gly Leu Pro Pro Ile Ser 
            180                 185                 190         


Asp Val Val Leu Asp Lys Ile Asn Gln Pro Lys Leu Pro Met Arg Thr 
        195                 200                 205             


Leu Asp Pro Arg Ile Leu Pro Arg Gly Pro Asp Phe Thr Pro Ala Phe 
    210                 215                 220                 


Ala Asp Phe Gly Arg Gln Thr Pro Gly Gly Arg Gly Val Pro Val Ser 
225                 230                 235                 240 


Ala Ser Ser Leu Gln Leu Thr 
                245         


<210> 6457
<211> 1305
<212> PRT
<213> Homo sapiens

<400> 6457
Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Phe Gln Arg Pro Gln 
1               5                   10                  15      


Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg 
            20                  25                  30          


Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile 
        35                  40                  45              


Met Met Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro 
    50                  55                  60                  


Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly 
65                  70                  75                  80  


Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr 
                85                  90                  95      


Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe 
            100                 105                 110         


Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr 
        115                 120                 125             


Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile 
    130                 135                 140                 


Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser 
                165                 170                 175     


Thr Pro Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser 
            180                 185                 190         


Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr 
        195                 200                 205             


Pro Val Thr Ala Ala Ser Asp Gln Lys Gln Ala Gln Ile Ala Ile Thr 
    210                 215                 220                 


Val Pro Lys Thr Trp Lys Lys Pro Lys Asp Arg Thr Arg Thr Thr Glu 
225                 230                 235                 240 


Glu Met Leu Glu Ala Glu Leu Glu Leu Lys Ala Glu Glu Glu Leu Ser 
                245                 250                 255     


Ile Asp Lys Val Leu Glu Ser Glu Gln Asp Lys Met Ser Gln Gly Phe 
            260                 265                 270         


His Pro Glu Arg Asp Pro Ser Asp Leu Lys Lys Val Lys Ala Val Glu 
        275                 280                 285             


Glu Asn Gly Glu Glu Ala Glu Pro Val Arg Asn Gly Ala Glu Ser Val 
    290                 295                 300                 


Ser Glu Gly Glu Gly Ile Asp Ala Asn Ser Gly Ser Thr Asp Ser Ser 
305                 310                 315                 320 


Gly Asp Gly Val Thr Phe Pro Phe Lys Pro Glu Ser Trp Lys Pro Thr 
                325                 330                 335     


Asp Thr Glu Gly Lys Lys Gln Tyr Asp Arg Glu Phe Leu Leu Asp Phe 
            340                 345                 350         


Gln Phe Met Pro Ala Cys Ile Gln Lys Pro Glu Gly Leu Pro Pro Ile 
        355                 360                 365             


Ser Asp Val Val Leu Asp Lys Ile Asn Gln Pro Lys Leu Pro Met Arg 
    370                 375                 380                 


Thr Leu Asp Pro Arg Ile Leu Pro Arg Gly Pro Asp Phe Thr Pro Ala 
385                 390                 395                 400 


Phe Ala Asp Phe Gly Arg Gln Thr Pro Gly Gly Arg Gly Val Pro Leu 
                405                 410                 415     


Leu Asn Val Gly Ser Arg Arg Ser Gln Pro Gly Gln Arg Arg Glu Pro 
            420                 425                 430         


Arg Lys Ile Ile Thr Val Ser Val Lys Glu Asp Val His Leu Lys Lys 
        435                 440                 445             


Ala Glu Asn Ala Trp Lys Pro Ser Gln Lys Arg Asp Ser Gln Ala Asp 
    450                 455                 460                 


Asp Pro Glu Asn Ile Lys Thr Gln Glu Leu Phe Arg Lys Val Arg Ser 
465                 470                 475                 480 


Ile Leu Asn Lys Leu Thr Pro Gln Met Phe Asn Gln Leu Met Lys Gln 
                485                 490                 495     


Val Ser Gly Leu Thr Val Asp Thr Glu Glu Arg Leu Lys Gly Val Ile 
            500                 505                 510         


Asp Leu Val Phe Glu Lys Ala Ile Asp Glu Pro Ser Phe Ser Val Ala 
        515                 520                 525             


Tyr Ala Asn Met Cys Arg Cys Leu Val Thr Leu Lys Val Pro Met Ala 
    530                 535                 540                 


Asp Lys Pro Gly Asn Thr Val Asn Phe Arg Lys Leu Leu Leu Asn Arg 
545                 550                 555                 560 


Cys Gln Lys Glu Phe Glu Lys Asp Lys Ala Asp Asp Asp Val Phe Glu 
                565                 570                 575     


Lys Lys Gln Lys Glu Leu Glu Ala Ala Ser Ala Pro Glu Glu Arg Thr 
            580                 585                 590         


Arg Leu His Asp Glu Leu Glu Glu Ala Lys Asp Lys Ala Arg Arg Arg 
        595                 600                 605             


Ser Ile Gly Asn Ile Lys Phe Ile Gly Glu Leu Phe Lys Leu Lys Met 
    610                 615                 620                 


Leu Thr Glu Ala Ile Met His Asp Cys Val Val Lys Leu Leu Lys Asn 
625                 630                 635                 640 


His Asp Glu Glu Ser Leu Glu Cys Leu Cys Arg Leu Leu Thr Thr Ile 
                645                 650                 655     


Gly Lys Asp Leu Asp Phe Glu Lys Ala Lys Pro Arg Met Asp Gln Tyr 
            660                 665                 670         


Phe Asn Gln Met Glu Lys Ile Val Lys Glu Arg Lys Thr Ser Ser Arg 
        675                 680                 685             


Ile Arg Phe Met Leu Gln Asp Val Ile Asp Leu Arg Leu Cys Asn Trp 
    690                 695                 700                 


Val Ser Arg Arg Ala Asp Gln Gly Pro Lys Thr Ile Glu Gln Ile His 
705                 710                 715                 720 


Lys Glu Ala Lys Ile Glu Glu Gln Glu Glu Gln Arg Lys Val Gln Gln 
                725                 730                 735     


Leu Met Thr Lys Glu Lys Arg Arg Pro Gly Val Gln Arg Val Asp Glu 
            740                 745                 750         


Gly Gly Trp Asn Thr Val Gln Gly Ala Lys Asn Ser Arg Val Leu Asp 
        755                 760                 765             


Pro Ser Lys Phe Leu Lys Ile Thr Lys Pro Thr Ile Asp Glu Lys Ile 
    770                 775                 780                 


Gln Leu Val Pro Lys Ala Gln Leu Gly Ser Trp Gly Lys Gly Ser Ser 
785                 790                 795                 800 


Gly Gly Ala Lys Ala Ser Glu Thr Asp Ala Leu Arg Ser Ser Ala Ser 
                805                 810                 815     


Ser Leu Asn Arg Phe Ser Ala Leu Gln Pro Pro Ala Pro Ser Gly Ser 
            820                 825                 830         


Thr Pro Ser Thr Pro Val Glu Phe Asp Ser Arg Arg Thr Leu Thr Ser 
        835                 840                 845             


Arg Gly Ser Met Gly Arg Glu Lys Asn Asp Lys Pro Leu Pro Ser Ala 
    850                 855                 860                 


Thr Ala Arg Pro Asn Thr Phe Met Arg Gly Gly Ser Ser Lys Asp Leu 
865                 870                 875                 880 


Leu Asp Asn Gln Ser Gln Glu Glu Gln Arg Arg Glu Met Leu Glu Thr 
                885                 890                 895     


Val Lys Gln Leu Thr Gly Gly Val Asp Val Glu Arg Asn Ser Thr Glu 
            900                 905                 910         


Ala Glu Arg Asn Lys Thr Arg Glu Ser Ala Lys Pro Glu Ile Ser Ala 
        915                 920                 925             


Met Ser Ala His Asp Lys Ala Ala Leu Ser Glu Glu Glu Leu Glu Arg 
    930                 935                 940                 


Lys Ser Lys Ser Ile Ile Asp Glu Phe Leu His Ile Asn Asp Phe Lys 
945                 950                 955                 960 


Glu Ala Met Gln Cys Val Glu Glu Leu Asn Ala Gln Gly Leu Leu His 
                965                 970                 975     


Val Phe Val Arg Val Gly Val Glu Ser Thr Leu Glu Arg Ser Gln Ile 
            980                 985                 990         


Thr Arg Asp His Met Gly Gln Leu  Leu Tyr Gln Leu Val  Gln Ser Glu 
        995                 1000                 1005             


Lys Leu  Ser Lys Gln Asp Phe  Phe Lys Gly Phe Ser  Glu Thr Leu 
    1010                 1015                 1020             


Glu Leu  Ala Asp Asp Met Ala  Ile Asp Ile Pro His  Ile Trp Leu 
    1025                 1030                 1035             


Tyr Leu  Ala Glu Leu Val Thr  Pro Met Leu Lys Glu  Gly Gly Ile 
    1040                 1045                 1050             


Ser Met  Arg Glu Leu Thr Ile  Glu Phe Ser Lys Pro  Leu Leu Pro 
    1055                 1060                 1065             


Val Gly  Arg Ala Gly Val Leu  Leu Ser Glu Ile Leu  His Leu Leu 
    1070                 1075                 1080             


Cys Lys  Gln Met Ser His Lys  Lys Val Gly Ala Leu  Trp Arg Glu 
    1085                 1090                 1095             


Ala Asp  Leu Ser Trp Lys Asp  Phe Leu Pro Glu Gly  Glu Asp Val 
    1100                 1105                 1110             


His Asn  Phe Leu Leu Glu Gln  Lys Leu Asp Phe Ile  Glu Ser Asp 
    1115                 1120                 1125             


Ser Pro  Cys Ser Ser Glu Ala  Leu Ser Lys Lys Glu  Leu Ser Ala 
    1130                 1135                 1140             


Glu Glu  Leu Tyr Lys Arg Leu  Glu Lys Leu Ile Ile  Glu Asp Lys 
    1145                 1150                 1155             


Ala Asn  Asp Glu Gln Ile Phe  Asp Trp Val Glu Ala  Asn Leu Asp 
    1160                 1165                 1170             


Glu Ile  Gln Met Ser Ser Pro  Thr Phe Leu Arg Ala  Leu Met Thr 
    1175                 1180                 1185             


Ala Val  Cys Lys Ala Ala Ile  Ile Ala Asp Ser Ser  Thr Phe Arg 
    1190                 1195                 1200             


Val Asp  Thr Ala Val Ile Lys  Gln Arg Val Pro Ile  Leu Leu Lys 
    1205                 1210                 1215             


Tyr Leu  Asp Ser Asp Thr Glu  Lys Glu Leu Gln Ala  Leu Tyr Ala 
    1220                 1225                 1230             


Leu Gln  Ala Ser Ile Val Lys  Leu Asp Gln Pro Ala  Asn Leu Leu 
    1235                 1240                 1245             


Arg Met  Phe Phe Asp Cys Leu  Tyr Asp Glu Glu Val  Ile Ser Glu 
    1250                 1255                 1260             


Asp Ala  Phe Tyr Lys Trp Glu  Ser Ser Lys Asp Pro  Ala Glu Gln 
    1265                 1270                 1275             


Asn Gly  Lys Gly Val Ala Leu  Lys Ser Val Thr Ala  Phe Phe Thr 
    1280                 1285                 1290             


Trp Leu  Arg Glu Ala Glu Glu  Glu Ser Glu Asp Asn  
    1295                 1300                 1305 


<210> 6458
<211> 1591
<212> PRT
<213> Homo sapiens

<400> 6458
Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Gly Gly Phe Arg Pro Ile 
1               5                   10                  15      


Gln Phe Phe Gln Arg Pro Gln Ile Gln Pro Pro Arg Ala Thr Ile Pro 
            20                  25                  30          


Asn Ser Ser Pro Ser Ile Arg Pro Gly Ala Gln Thr Pro Thr Ala Val 
        35                  40                  45              


Tyr Gln Ala Asn Gln His Ile Met Met Val Asn His Leu Pro Met Pro 
    50                  55                  60                  


Tyr Pro Val Pro Gln Gly Pro Gln Tyr Cys Ile Pro Gln Tyr Arg His 
65                  70                  75                  80  


Ser Gly Pro Pro Tyr Val Gly Pro Pro Gln Gln Tyr Pro Val Gln Pro 
                85                  90                  95      


Pro Gly Pro Gly Pro Phe Tyr Pro Gly Pro Gly Pro Gly Asp Phe Pro 
            100                 105                 110         


Asn Ala Tyr Gly Thr Pro Phe Tyr Pro Ser Gln Pro Val Tyr Gln Ser 
        115                 120                 125             


Ala Pro Ile Ile Val Pro Thr Gln Gln Gln Pro Pro Pro Ala Lys Arg 
    130                 135                 140                 


Glu Lys Lys Thr Ile Arg Ile Arg Asp Pro Asn Gln Gly Gly Lys Asp 
145                 150                 155                 160 


Ile Thr Glu Glu Ile Met Ser Gly Gly Gly Ser Arg Asn Pro Thr Pro 
                165                 170                 175     


Pro Ile Gly Arg Pro Thr Ser Thr Pro Thr Pro Pro Gln Leu Pro Ser 
            180                 185                 190         


Gln Val Pro Glu His Ser Pro Val Val Tyr Gly Thr Val Glu Ser Ala 
        195                 200                 205             


His Leu Ala Ala Ser Thr Pro Val Thr Ala Ala Ser Asp Gln Lys Gln 
    210                 215                 220                 


Glu Glu Lys Pro Lys Pro Asp Pro Val Leu Lys Ser Pro Ser Pro Val 
225                 230                 235                 240 


Leu Arg Leu Val Leu Ser Gly Glu Lys Lys Glu Gln Glu Gly Gln Thr 
                245                 250                 255     


Ser Glu Thr Thr Ala Ile Val Ser Ile Ala Glu Leu Pro Leu Pro Pro 
            260                 265                 270         


Ser Pro Thr Thr Val Ser Ser Val Ala Arg Ser Thr Ile Ala Ala Pro 
        275                 280                 285             


Thr Ser Ser Ala Leu Ser Ser Gln Pro Ile Phe Thr Thr Ala Ile Asp 
    290                 295                 300                 


Asp Arg Cys Glu Leu Ser Ser Pro Arg Glu Asp Thr Ile Pro Ile Pro 
305                 310                 315                 320 


Ser Leu Thr Ser Cys Thr Glu Thr Ser Asp Pro Leu Pro Thr Asn Glu 
                325                 330                 335     


Asn Asp Asp Asp Ile Cys Lys Lys Pro Cys Ser Val Ala Pro Asn Asp 
            340                 345                 350         


Ile Pro Leu Val Ser Ser Thr Asn Leu Ile Asn Glu Ile Asn Gly Val 
        355                 360                 365             


Ser Glu Lys Leu Ser Ala Thr Glu Ser Ile Val Glu Ile Val Lys Gln 
    370                 375                 380                 


Glu Val Leu Pro Leu Thr Leu Glu Leu Glu Ile Leu Glu Asn Pro Pro 
385                 390                 395                 400 


Glu Glu Met Lys Leu Glu Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr 
                405                 410                 415     


Val Pro Ser Phe Pro Pro Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro 
            420                 425                 430         


His Thr Pro Val Ile Val Pro Ala Ala Ala Thr Thr Val Ser Ser Pro 
        435                 440                 445             


Ser Ala Ala Ile Thr Val Gln Arg Val Leu Glu Glu Asp Glu Ser Ile 
    450                 455                 460                 


Arg Thr Cys Leu Ser Glu Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu 
465                 470                 475                 480 


Val Glu Ala Asp Gly Gln Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu 
                485                 490                 495     


Asn Ser Arg Arg Ser Pro Val Pro Ala Gln Ile Ala Ile Thr Val Pro 
            500                 505                 510         


Lys Thr Trp Lys Lys Pro Lys Asp Arg Thr Arg Thr Thr Glu Glu Met 
        515                 520                 525             


Leu Glu Ala Glu Leu Glu Leu Lys Ala Glu Glu Glu Leu Ser Ile Asp 
    530                 535                 540                 


Lys Val Leu Glu Ser Glu Gln Asp Lys Met Ser Gln Gly Phe His Pro 
545                 550                 555                 560 


Glu Arg Asp Pro Ser Asp Leu Lys Lys Val Lys Ala Val Glu Glu Asn 
                565                 570                 575     


Gly Glu Glu Ala Glu Pro Val Arg Asn Gly Ala Glu Ser Val Ser Glu 
            580                 585                 590         


Gly Glu Gly Ile Asp Ala Asn Ser Gly Ser Thr Asp Ser Ser Gly Asp 
        595                 600                 605             


Gly Val Thr Phe Pro Phe Lys Pro Glu Ser Trp Lys Pro Thr Asp Thr 
    610                 615                 620                 


Glu Gly Lys Lys Gln Tyr Asp Arg Glu Phe Leu Leu Asp Phe Gln Phe 
625                 630                 635                 640 


Met Pro Ala Cys Ile Gln Lys Pro Glu Gly Leu Pro Pro Ile Ser Asp 
                645                 650                 655     


Val Val Leu Asp Lys Ile Asn Gln Pro Lys Leu Pro Met Arg Thr Leu 
            660                 665                 670         


Asp Pro Arg Ile Leu Pro Arg Gly Pro Asp Phe Thr Pro Ala Phe Ala 
        675                 680                 685             


Asp Phe Gly Arg Gln Thr Pro Gly Gly Arg Gly Val Pro Leu Leu Asn 
    690                 695                 700                 


Val Gly Ser Arg Arg Ser Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys 
705                 710                 715                 720 


Ile Ile Thr Val Ser Val Lys Glu Asp Val His Leu Lys Lys Ala Glu 
                725                 730                 735     


Asn Ala Trp Lys Pro Ser Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro 
            740                 745                 750         


Glu Asn Ile Lys Thr Gln Glu Leu Phe Arg Lys Val Arg Ser Ile Leu 
        755                 760                 765             


Asn Lys Leu Thr Pro Gln Met Phe Asn Gln Leu Met Lys Gln Val Ser 
    770                 775                 780                 


Gly Leu Thr Val Asp Thr Glu Glu Arg Leu Lys Gly Val Ile Asp Leu 
785                 790                 795                 800 


Val Phe Glu Lys Ala Ile Asp Glu Pro Ser Phe Ser Val Ala Tyr Ala 
                805                 810                 815     


Asn Met Cys Arg Cys Leu Val Thr Leu Lys Val Pro Met Ala Asp Lys 
            820                 825                 830         


Pro Gly Asn Thr Val Asn Phe Arg Lys Leu Leu Leu Asn Arg Cys Gln 
        835                 840                 845             


Lys Glu Phe Glu Lys Asp Lys Ala Asp Asp Asp Val Phe Glu Lys Lys 
    850                 855                 860                 


Gln Lys Glu Leu Glu Ala Ala Ser Ala Pro Glu Glu Arg Thr Arg Leu 
865                 870                 875                 880 


His Asp Glu Leu Glu Glu Ala Lys Asp Lys Ala Arg Arg Arg Ser Ile 
                885                 890                 895     


Gly Asn Ile Lys Phe Ile Gly Glu Leu Phe Lys Leu Lys Met Leu Thr 
            900                 905                 910         


Glu Ala Ile Met His Asp Cys Val Val Lys Leu Leu Lys Asn His Asp 
        915                 920                 925             


Glu Glu Ser Leu Glu Cys Leu Cys Arg Leu Leu Thr Thr Ile Gly Lys 
    930                 935                 940                 


Asp Leu Asp Phe Glu Lys Ala Lys Pro Arg Met Asp Gln Tyr Phe Asn 
945                 950                 955                 960 


Gln Met Glu Lys Ile Val Lys Glu Arg Lys Thr Ser Ser Arg Ile Arg 
                965                 970                 975     


Phe Met Leu Gln Asp Val Ile Asp Leu Arg Leu Cys Asn Trp Val Ser 
            980                 985                 990         


Arg Arg Ala Asp Gln Gly Pro Lys  Thr Ile Glu Gln Ile  His Lys Glu 
        995                 1000                 1005             


Ala Lys  Ile Glu Glu Gln Glu  Glu Gln Arg Lys Val  Gln Gln Leu 
    1010                 1015                 1020             


Met Thr  Lys Glu Lys Arg Arg  Pro Gly Val Gln Arg  Val Asp Glu 
    1025                 1030                 1035             


Gly Gly  Trp Asn Thr Val Gln  Gly Ala Lys Asn Ser  Arg Val Leu 
    1040                 1045                 1050             


Asp Pro  Ser Lys Phe Leu Lys  Ile Thr Lys Pro Thr  Ile Asp Glu 
    1055                 1060                 1065             


Lys Ile  Gln Leu Val Pro Lys  Ala Gln Leu Gly Ser  Trp Gly Lys 
    1070                 1075                 1080             


Gly Ser  Ser Gly Gly Ala Lys  Ala Ser Glu Thr Asp  Ala Leu Arg 
    1085                 1090                 1095             


Ser Ser  Ala Ser Ser Leu Asn  Arg Phe Ser Ala Leu  Gln Pro Pro 
    1100                 1105                 1110             


Ala Pro  Ser Gly Ser Thr Pro  Ser Thr Pro Val Glu  Phe Asp Ser 
    1115                 1120                 1125             


Arg Arg  Thr Leu Thr Ser Arg  Gly Ser Met Gly Arg  Glu Lys Asn 
    1130                 1135                 1140             


Asp Lys  Pro Leu Pro Ser Ala  Thr Ala Arg Pro Asn  Thr Phe Met 
    1145                 1150                 1155             


Arg Gly  Gly Ser Ser Lys Asp  Leu Leu Asp Asn Gln  Ser Gln Glu 
    1160                 1165                 1170             


Glu Gln  Arg Arg Glu Met Leu  Glu Thr Val Lys Gln  Leu Thr Gly 
    1175                 1180                 1185             


Gly Val  Asp Val Glu Arg Asn  Ser Thr Glu Ala Glu  Arg Asn Lys 
    1190                 1195                 1200             


Thr Arg  Glu Ser Ala Lys Pro  Glu Ile Ser Ala Met  Ser Ala His 
    1205                 1210                 1215             


Asp Lys  Ala Ala Leu Ser Glu  Glu Glu Leu Glu Arg  Lys Ser Lys 
    1220                 1225                 1230             


Ser Ile  Ile Asp Glu Phe Leu  His Ile Asn Asp Phe  Lys Glu Ala 
    1235                 1240                 1245             


Met Gln  Cys Val Glu Glu Leu  Asn Ala Gln Gly Leu  Leu His Val 
    1250                 1255                 1260             


Phe Val  Arg Val Gly Val Glu  Ser Thr Leu Glu Arg  Ser Gln Ile 
    1265                 1270                 1275             


Thr Arg  Asp His Met Gly Gln  Leu Leu Tyr Gln Leu  Val Gln Ser 
    1280                 1285                 1290             


Glu Lys  Leu Ser Lys Gln Asp  Phe Phe Lys Gly Phe  Ser Glu Thr 
    1295                 1300                 1305             


Leu Glu  Leu Ala Asp Asp Met  Ala Ile Asp Ile Pro  His Ile Trp 
    1310                 1315                 1320             


Leu Tyr  Leu Ala Glu Leu Val  Thr Pro Met Leu Lys  Glu Gly Gly 
    1325                 1330                 1335             


Ile Ser  Met Arg Glu Leu Thr  Ile Glu Phe Ser Lys  Pro Leu Leu 
    1340                 1345                 1350             


Pro Val  Gly Arg Ala Gly Val  Leu Leu Ser Glu Ile  Leu His Leu 
    1355                 1360                 1365             


Leu Cys  Lys Gln Met Ser His  Lys Lys Val Gly Ala  Leu Trp Arg 
    1370                 1375                 1380             


Glu Ala  Asp Leu Ser Trp Lys  Asp Phe Leu Pro Glu  Gly Glu Asp 
    1385                 1390                 1395             


Val His  Asn Phe Leu Leu Glu  Gln Lys Leu Asp Phe  Ile Glu Ser 
    1400                 1405                 1410             


Asp Ser  Pro Cys Ser Ser Glu  Ala Leu Ser Lys Lys  Glu Leu Ser 
    1415                 1420                 1425             


Ala Glu  Glu Leu Tyr Lys Arg  Leu Glu Lys Leu Ile  Ile Glu Asp 
    1430                 1435                 1440             


Lys Ala  Asn Asp Glu Gln Ile  Phe Asp Trp Val Glu  Ala Asn Leu 
    1445                 1450                 1455             


Asp Glu  Ile Gln Met Ser Ser  Pro Thr Phe Leu Arg  Ala Leu Met 
    1460                 1465                 1470             


Thr Ala  Val Cys Lys Ala Ala  Ile Ile Ala Asp Ser  Ser Thr Phe 
    1475                 1480                 1485             


Arg Val  Asp Thr Ala Val Ile  Lys Gln Arg Val Pro  Ile Leu Leu 
    1490                 1495                 1500             


Lys Tyr  Leu Asp Ser Asp Thr  Glu Lys Glu Leu Gln  Ala Leu Tyr 
    1505                 1510                 1515             


Ala Leu  Gln Ala Ser Ile Val  Lys Leu Asp Gln Pro  Ala Asn Leu 
    1520                 1525                 1530             


Leu Arg  Met Phe Phe Asp Cys  Leu Tyr Asp Glu Glu  Val Ile Ser 
    1535                 1540                 1545             


Glu Asp  Ala Phe Tyr Lys Trp  Glu Ser Ser Lys Asp  Pro Ala Glu 
    1550                 1555                 1560             


Gln Asn  Gly Lys Gly Val Ala  Leu Lys Ser Val Thr  Ala Phe Phe 
    1565                 1570                 1575             


Thr Trp  Leu Arg Glu Ala Glu  Glu Glu Ser Glu Asp  Asn 
    1580                 1585                 1590     


<210> 6459
<211> 333
<212> PRT
<213> Homo sapiens

<400> 6459
Met Ser Gly Asp Glu Met Ile Phe Asp Pro Thr Met Ser Lys Lys Lys 
1               5                   10                  15      


Lys Lys Lys Lys Lys Pro Phe Met Leu Asp Glu Glu Gly Asp Thr Gln 
            20                  25                  30          


Thr Glu Glu Thr Gln Pro Ser Glu Thr Lys Glu Val Glu Pro Glu Pro 
        35                  40                  45              


Thr Glu Asp Lys Asp Leu Glu Ala Asp Glu Glu Asp Thr Arg Lys Lys 
    50                  55                  60                  


Asp Ala Ser Asp Asp Leu Asp Asp Leu Asn Phe Phe Asn Gln Lys Lys 
65                  70                  75                  80  


Lys Lys Lys Lys Thr Lys Lys Ile Phe Asp Ile Asp Glu Ala Glu Glu 
                85                  90                  95      


Gly Val Lys Asp Leu Lys Ile Glu Ser Asp Val Gln Glu Pro Thr Glu 
            100                 105                 110         


Pro Glu Asp Asp Leu Asp Ile Met Leu Gly Asn Lys Lys Lys Lys Lys 
        115                 120                 125             


Lys Asn Val Lys Phe Pro Asp Glu Asp Glu Ile Leu Glu Lys Asp Glu 
    130                 135                 140                 


Ala Leu Glu Asp Glu Asp Asn Lys Lys Asp Asp Gly Ile Ser Phe Ser 
145                 150                 155                 160 


Asn Gln Thr Gly Pro Ala Trp Ala Gly Ser Glu Arg Asp Tyr Thr Tyr 
                165                 170                 175     


Glu Glu Leu Leu Asn Arg Val Phe Asn Ile Met Arg Glu Lys Asn Pro 
            180                 185                 190         


Asp Met Val Ala Gly Glu Lys Arg Lys Phe Val Met Lys Pro Pro Gln 
        195                 200                 205             


Val Val Arg Val Gly Thr Lys Lys Thr Ser Phe Val Asn Phe Thr Asp 
    210                 215                 220                 


Ile Cys Lys Leu Leu His Arg Gln Pro Lys His Leu Leu Ala Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Leu Gly Thr Ser Gly Ser Ile Asp Gly Asn Asn Gln Leu 
                245                 250                 255     


Val Ile Lys Gly Arg Phe Gln Gln Lys Gln Ile Glu Asn Val Leu Arg 
            260                 265                 270         


Arg Tyr Ile Lys Glu Tyr Val Thr Cys His Thr Cys Arg Ser Pro Asp 
        275                 280                 285             


Thr Ile Leu Gln Lys Asp Thr Arg Leu Tyr Phe Leu Gln Cys Glu Thr 
    290                 295                 300                 


Cys His Ser Arg Cys Ser Val Ala Ser Ile Lys Thr Gly Phe Gln Ala 
305                 310                 315                 320 


Val Thr Gly Lys Arg Ala Gln Leu Arg Ala Lys Ala Asn 
                325                 330             


<210> 6460
<211> 872
<212> PRT
<213> Homo sapiens

<400> 6460
Met Gly Glu Gly Gly Leu Pro Pro Ala Phe Gln Leu Leu Leu Arg Ala 
1               5                   10                  15      


Cys Asp Gln Gly Asp Thr Glu Thr Ala Arg Arg Leu Leu Glu Pro Gly 
            20                  25                  30          


Ala Ala Glu Pro Ala Glu Arg Gly Ala Glu Pro Glu Ala Gly Ala Glu 
        35                  40                  45              


Pro Ala Gly Ala Glu Val Ala Gly Pro Gly Ala Ala Ala Ala Gly Ala 
    50                  55                  60                  


Val Gly Ala Pro Val Pro Val Asp Cys Ser Asp Glu Ala Gly Asn Thr 
65                  70                  75                  80  


Ala Leu Gln Phe Ala Ala Ala Gly Gly His Glu Pro Leu Val Arg Phe 
                85                  90                  95      


Leu Leu Arg Arg Gly Ala Ser Val Asn Ser Arg Asn His Tyr Gly Trp 
            100                 105                 110         


Ser Ala Leu Met Gln Ala Ala Arg Phe Gly His Val Ser Val Ala His 
        115                 120                 125             


Leu Leu Leu Asp His Gly Ala Asp Val Asn Ala Gln Asn Arg Leu Gly 
    130                 135                 140                 


Ala Ser Val Leu Thr Val Ala Ser Arg Gly Gly His Leu Gly Val Val 
145                 150                 155                 160 


Lys Leu Leu Leu Glu Ala Gly Ala Phe Val Asp His His His Pro Ser 
                165                 170                 175     


Gly Glu Gln Leu Gly Leu Gly Gly Ser Arg Asp Glu Pro Leu Asp Ile 
            180                 185                 190         


Thr Ala Leu Met Ala Ala Ile Gln His Gly His Glu Ala Val Val Arg 
        195                 200                 205             


Leu Leu Met Glu Trp Gly Ala Asp Pro Asn His Ala Ala Arg Thr Val 
    210                 215                 220                 


Gly Trp Ser Pro Leu Met Leu Ala Ala Leu Thr Gly Arg Leu Gly Val 
225                 230                 235                 240 


Ala Gln Gln Leu Val Glu Lys Gly Ala Asn Pro Asp His Leu Ser Val 
                245                 250                 255     


Leu Glu Lys Thr Ala Phe Glu Val Ala Leu Asp Cys Lys His Arg Asp 
            260                 265                 270         


Leu Val Asp Tyr Leu Asp Pro Leu Thr Thr Val Arg Pro Lys Thr Asp 
        275                 280                 285             


Glu Glu Lys Arg Arg Pro Asp Ile Phe His Ala Leu Lys Met Gly Asn 
    290                 295                 300                 


Phe Gln Leu Val Lys Glu Ile Ala Asp Glu Asp Pro Ser His Val Asn 
305                 310                 315                 320 


Leu Val Asn Gly Asp Gly Ala Thr Pro Leu Met Leu Ala Ala Val Thr 
                325                 330                 335     


Gly Gln Leu Ala Leu Val Gln Leu Leu Val Glu Arg His Ala Asp Val 
            340                 345                 350         


Asp Lys Gln Asp Ser Val His Gly Trp Thr Ala Leu Met Gln Ala Thr 
        355                 360                 365             


Tyr His Gly Asn Lys Glu Ile Val Lys Tyr Leu Leu Asn Gln Gly Ala 
    370                 375                 380                 


Asp Val Thr Leu Arg Ala Lys Asn Gly Tyr Thr Ala Phe Asp Leu Val 
385                 390                 395                 400 


Met Leu Leu Asn Asp Pro Asp Thr Glu Leu Val Arg Leu Leu Ala Ser 
                405                 410                 415     


Val Cys Met Gln Val Asn Lys Asp Lys Gly Arg Pro Ser His Gln Pro 
            420                 425                 430         


Pro Leu Pro His Ser Lys Val Arg Gln Pro Trp Ser Ile Pro Val Leu 
        435                 440                 445             


Pro Asp Asp Lys Gly Gly Leu Lys Ser Trp Trp Asn Arg Met Ser Asn 
    450                 455                 460                 


Arg Phe Arg Lys Leu Lys Leu Met Gln Thr Leu Pro Arg Gly Leu Ser 
465                 470                 475                 480 


Ser Asn Gln Pro Leu Pro Phe Ser Asp Glu Pro Glu Pro Ala Leu Asp 
                485                 490                 495     


Ser Thr Met Arg Ala Ala Pro Gln Asp Lys Thr Ser Arg Ser Ala Leu 
            500                 505                 510         


Pro Asp Ala Ala Pro Val Thr Lys Asp Asn Gly Pro Gly Ser Thr Arg 
        515                 520                 525             


Gly Glu Lys Glu Asp Thr Leu Leu Thr Thr Met Leu Arg Asn Gly Ala 
    530                 535                 540                 


Pro Leu Thr Arg Leu Pro Ser Asp Lys Leu Lys Ala Val Ile Pro Pro 
545                 550                 555                 560 


Phe Leu Pro Pro Ser Ser Phe Glu Leu Trp Ser Ser Asp Arg Ser Arg 
                565                 570                 575     


Thr Arg His Asn Gly Lys Ala Asp Pro Met Lys Thr Ala Leu Pro Gln 
            580                 585                 590         


Arg Ala Ser Arg Gly His Pro Val Gly Gly Gly Gly Thr Asp Thr Thr 
        595                 600                 605             


Pro Val Arg Pro Val Lys Phe Pro Ser Leu Pro Arg Ser Pro Ala Ser 
    610                 615                 620                 


Ser Ala Asn Ser Gly Asn Phe Asn His Ser Pro His Ser Ser Gly Gly 
625                 630                 635                 640 


Ser Ser Gly Val Gly Val Ser Arg His Gly Gly Glu Leu Leu Asn Arg 
                645                 650                 655     


Ser Gly Gly Ser Ile Asp Asn Val Leu Ser Gln Ile Ala Ala Gln Arg 
            660                 665                 670         


Lys Lys Ala Ala Gly Leu Leu Glu Gln Lys Pro Ser His Arg Ser Ser 
        675                 680                 685             


Pro Val Gly Pro Ala Pro Gly Ser Ser Pro Ser Glu Leu Pro Ala Ser 
    690                 695                 700                 


Pro Ala Gly Gly Ser Ala Pro Val Gly Lys Gln Lys Leu Glu Thr Ser 
705                 710                 715                 720 


Lys Arg Pro Pro Ser Gly Thr Ser Thr Thr Ser Lys Ser Thr Ser Pro 
                725                 730                 735     


Thr Leu Thr Pro Ser Pro Ser Pro Lys Gly His Thr Ala Glu Ser Ser 
            740                 745                 750         


Val Ser Ser Ser Ser Ser His Arg Gln Ser Lys Ser Ser Gly Gly Ser 
        755                 760                 765             


Ser Ser Gly Thr Ile Thr Asp Glu Asp Glu Leu Thr Gly Ile Leu Lys 
    770                 775                 780                 


Lys Leu Ser Leu Glu Lys Tyr Gln Pro Ile Phe Glu Glu Gln Glu Val 
785                 790                 795                 800 


Asp Met Glu Ala Phe Leu Thr Leu Thr Asp Gly Asp Leu Lys Glu Leu 
                805                 810                 815     


Gly Ile Lys Thr Asp Gly Ser Arg Gln Gln Ile Leu Ala Ala Ile Ser 
            820                 825                 830         


Glu Leu Asn Ala Gly Lys Gly Arg Glu Arg Gln Ile Leu Gln Glu Thr 
        835                 840                 845             


Ile His Asn Phe His Ser Ser Phe Glu Ser Ser Ala Ser Asn Thr Arg 
    850                 855                 860                 


Ala Pro Gly Asn Ser Pro Cys Ala 
865                 870         


<210> 6461
<211> 160
<212> PRT
<213> Homo sapiens

<400> 6461
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 6462
<211> 160
<212> PRT
<213> Homo sapiens

<400> 6462
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 6463
<211> 929
<212> PRT
<213> Homo sapiens

<400> 6463
Met Gln Gly Leu Pro Asp Pro Pro Ser Gln Arg Gly Ile Ile Pro Arg 
1               5                   10                  15      


Ala Phe Glu His Val Phe Glu Ser Val Gln Cys Ala Glu Asn Thr Lys 
            20                  25                  30          


Phe Leu Val Arg Ala Ser Tyr Leu Glu Ile Tyr Asn Glu Asp Val Arg 
        35                  40                  45              


Asp Leu Leu Gly Ala Asp Thr Lys Gln Lys Leu Glu Leu Lys Glu His 
    50                  55                  60                  


Pro Glu Lys Gly Val Tyr Val Lys Gly Leu Ser Met His Thr Val His 
65                  70                  75                  80  


Ser Val Ala Gln Cys Glu His Ile Met Glu Thr Gly Trp Lys Asn Arg 
                85                  90                  95      


Ser Val Gly Tyr Thr Leu Met Asn Lys Asp Ser Ser Arg Ser His Ser 
            100                 105                 110         


Ile Phe Thr Ile Ser Ile Glu Met Ser Ala Val Asp Glu Arg Gly Lys 
        115                 120                 125             


Asp His Leu Arg Ala Gly Lys Leu Asn Leu Val Asp Leu Ala Gly Ser 
    130                 135                 140                 


Glu Arg Gln Ser Lys Thr Gly Ala Thr Gly Glu Arg Leu Lys Glu Ala 
145                 150                 155                 160 


Thr Lys Ile Asn Leu Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala 
                165                 170                 175     


Leu Val Asp Gly Arg Cys Lys His Val Pro Tyr Arg Asp Ser Lys Leu 
            180                 185                 190         


Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Thr Lys Thr Leu Met 
        195                 200                 205             


Val Ala Cys Leu Ser Pro Ala Asp Asn Asn Tyr Asp Glu Thr Leu Ser 
    210                 215                 220                 


Thr Leu Arg Tyr Ala Asn Arg Ala Lys Asn Ile Arg Asn Lys Pro Arg 
225                 230                 235                 240 


Ile Asn Glu Asp Pro Lys Asp Ala Leu Leu Arg Glu Tyr Gln Glu Glu 
                245                 250                 255     


Ile Lys Lys Leu Lys Ala Ile Leu Thr Gln Gln Met Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Leu Leu Ser Arg Gln Val Pro Pro Asp Pro Val Gln Val 
        275                 280                 285             


Glu Glu Lys Leu Leu Pro Gln Pro Val Ile Gln His Asp Val Glu Ala 
    290                 295                 300                 


Glu Lys Gln Leu Ile Arg Glu Glu Tyr Glu Glu Arg Leu Ala Arg Leu 
305                 310                 315                 320 


Lys Ala Asp Tyr Lys Ala Glu Gln Glu Ser Arg Ala Arg Leu Glu Glu 
                325                 330                 335     


Asp Ile Thr Ala Met Arg Asn Ser Tyr Asp Val Arg Leu Ser Thr Leu 
            340                 345                 350         


Glu Glu Asn Leu Arg Lys Glu Thr Glu Ala Val Leu Gln Val Gly Val 
        355                 360                 365             


Leu Tyr Lys Ala Glu Val Met Ser Arg Ala Glu Phe Ala Ser Ser Ala 
    370                 375                 380                 


Glu Tyr Pro Pro Ala Phe Gln Tyr Glu Thr Val Val Lys Pro Lys Val 
385                 390                 395                 400 


Phe Ser Thr Thr Asp Thr Leu Pro Ser Asp Asp Val Ser Lys Thr Gln 
                405                 410                 415     


Val Ser Ser Arg Phe Ala Glu Leu Pro Lys Val Glu Pro Ser Lys Ser 
            420                 425                 430         


Glu Ile Ser Leu Gly Ser Ser Glu Ser Ser Ser Leu Glu Glu Thr Ser 
        435                 440                 445             


Val Ser Glu Ala Phe Pro Gly Pro Glu Glu Pro Ser Asn Val Glu Val 
    450                 455                 460                 


Ser Met Pro Thr Glu Glu Ser Arg Ser Arg Tyr Phe Leu Asp Glu Cys 
465                 470                 475                 480 


Leu Gly Gln Glu Ala Ala Gly His Leu Leu Gly Glu Gln Asn Tyr Leu 
                485                 490                 495     


Pro Gln Glu Glu Pro Gln Glu Val Pro Leu Gln Gly Leu Leu Gly Leu 
            500                 505                 510         


Gln Asp Pro Phe Ala Glu Val Glu Ala Lys Leu Ala Arg Leu Ser Ser 
        515                 520                 525             


Thr Val Ala Arg Thr Asp Ala Pro Gln Ala Asp Val Pro Lys Val Pro 
    530                 535                 540                 


Val Gln Val Pro Ala Pro Thr Asp Leu Leu Glu Pro Ser Asp Ala Arg 
545                 550                 555                 560 


Pro Glu Ala Glu Ala Ala Asp Asp Phe Pro Pro Arg Pro Glu Val Asp 
                565                 570                 575     


Leu Ala Ser Glu Val Ala Leu Glu Val Val Arg Thr Ala Glu Pro Gly 
            580                 585                 590         


Val Trp Leu Glu Ala Gln Ala Pro Val Ala Leu Val Ala Gln Pro Glu 
        595                 600                 605             


Pro Leu Pro Ala Thr Ala Gly Val Lys Arg Glu Ser Val Gly Met Glu 
    610                 615                 620                 


Val Ala Val Leu Thr Asp Asp Pro Leu Pro Val Val Asp Gln Gln Gln 
625                 630                 635                 640 


Val Leu Ala Arg Leu Gln Leu Leu Glu Gln Gln Val Val Gly Gly Glu 
                645                 650                 655     


Gln Ala Lys Asn Lys Asp Leu Lys Glu Lys His Lys Arg Arg Lys Arg 
            660                 665                 670         


Tyr Ala Asp Glu Arg Arg Lys Gln Leu Val Ala Ala Leu Gln Asn Ser 
        675                 680                 685             


Asp Glu Asp Ser Gly Asp Trp Val Leu Leu Asn Val Tyr Asp Ser Ile 
    690                 695                 700                 


Gln Glu Glu Val Arg Ala Lys Ser Lys Leu Leu Glu Lys Met Gln Arg 
705                 710                 715                 720 


Lys Leu Arg Ala Ala Glu Val Glu Ile Lys Asp Leu Gln Ser Glu Phe 
                725                 730                 735     


Gln Leu Glu Lys Ile Asp Tyr Leu Ala Thr Ile Arg Arg Gln Glu Arg 
            740                 745                 750         


Asp Ser Met Leu Leu Gln Gln Leu Leu Glu Gln Val Gln Pro Leu Ile 
        755                 760                 765             


Arg Arg Asp Cys Asn Tyr Ser Asn Leu Glu Lys Ile Leu Arg Glu Ser 
    770                 775                 780                 


Cys Trp Asp Glu Asp Asn Gly Phe Trp Lys Ile Pro His Pro Val Ile 
785                 790                 795                 800 


Thr Lys Thr Ser Leu Pro Val Ala Val Ser Thr Gly Pro Gln Asn Lys 
                805                 810                 815     


Pro Ala Arg Lys Thr Ser Ala Ala Asp Asn Gly Glu Pro Asn Met Glu 
            820                 825                 830         


Asp Asp Arg Tyr Arg Leu Met Leu Ser Arg Ser Asn Ser Glu Asn Ile 
        835                 840                 845             


Ala Ser Asn Tyr Phe Arg Ser Lys Arg Ala Ser Gln Ile Leu Ser Thr 
    850                 855                 860                 


Asp Ala Arg Lys Ser Leu Thr His His Asn Ser Pro Pro Gly Leu Ser 
865                 870                 875                 880 


Cys Pro Leu Ser Asn Asn Ser Ala Ile Pro Pro Thr Gln Ala Pro Glu 
                885                 890                 895     


Met Pro Gln Pro Arg Pro Phe Arg Leu Glu Ser Leu Asp Ile Pro Phe 
            900                 905                 910         


Thr Lys Ala Lys Arg Lys Lys Ser Lys Ser Asn Phe Gly Ser Glu Pro 
        915                 920                 925             


Leu 
    


<210> 6464
<211> 141
<212> PRT
<213> Homo sapiens

<400> 6464
Met Asn Lys His Val Leu Lys Ile Gln Lys Glu Leu Glu Glu Ala Lys 
1               5                   10                  15      


Glu Lys Leu Ala Arg Gln His Lys Arg Arg Ser Asp Asp Asp Asp Arg 
            20                  25                  30          


Ser Ser Asp Arg Lys Asp Gly Val Leu Glu Glu Gln Ile Glu Arg Leu 
        35                  40                  45              


Gln Glu Lys Val Glu Ser Ala Gln Ser Glu Gln Lys Asn Leu Phe Leu 
    50                  55                  60                  


Val Ile Phe Gln Arg Phe Ile Met Ile Leu Thr Glu His Leu Val Arg 
65                  70                  75                  80  


Cys Glu Thr Asp Gly Thr Ser Val Leu Thr Pro Trp Tyr Lys Asn Cys 
                85                  90                  95      


Ile Glu Arg Leu Gln Gln Ile Phe Leu Gln Val Cys Gly Glu Leu Arg 
            100                 105                 110         


Leu Gly Asn Asn Thr Ile Leu Ser His Lys Asp Phe Ser Leu Lys Lys 
        115                 120                 125             


Ile Leu Val Lys Phe Val Arg Arg Leu Tyr Ser Thr Cys 
    130                 135                 140     


<210> 6465
<211> 790
<212> PRT
<213> Homo sapiens

<400> 6465
Met Ser Arg Arg Arg His Ser Asp Glu Asn Asp Gly Gly Gln Pro His 
1               5                   10                  15      


Lys Arg Arg Lys Thr Ser Asp Ala Asn Glu Thr Glu Asp His Leu Glu 
            20                  25                  30          


Ser Leu Ile Cys Lys Val Gly Glu Lys Ser Ala Cys Ser Leu Glu Ser 
        35                  40                  45              


Asn Leu Glu Gly Leu Ala Gly Val Leu Glu Ala Asp Leu Pro Asn Tyr 
    50                  55                  60                  


Lys Ser Lys Ile Leu Arg Leu Leu Cys Thr Val Ala Arg Leu Leu Pro 
65                  70                  75                  80  


Glu Lys Leu Thr Ile Tyr Thr Thr Leu Val Gly Leu Leu Asn Ala Arg 
                85                  90                  95      


Asn Tyr Asn Phe Gly Gly Glu Phe Val Glu Ala Met Ile Arg Gln Leu 
            100                 105                 110         


Lys Glu Ser Leu Lys Ala Asn Asn Tyr Asn Glu Ala Val Tyr Leu Val 
        115                 120                 125             


Arg Phe Leu Ser Asp Leu Val Asn Cys His Val Ile Ala Ala Pro Ser 
    130                 135                 140                 


Met Val Ala Met Phe Glu Asn Phe Val Ser Val Thr Gln Glu Glu Asp 
145                 150                 155                 160 


Val Pro Gln Val Arg Arg Asp Trp Tyr Val Tyr Ala Phe Leu Ser Ser 
                165                 170                 175     


Leu Pro Trp Val Gly Lys Glu Leu Tyr Glu Lys Lys Asp Ala Glu Met 
            180                 185                 190         


Asp Arg Ile Phe Ala Asn Thr Glu Ser Tyr Leu Lys Arg Arg Gln Lys 
        195                 200                 205             


Thr His Val Pro Met Leu Gln Val Trp Thr Ala Asp Lys Pro His Pro 
    210                 215                 220                 


Gln Glu Glu Tyr Leu Asp Cys Leu Trp Ala Gln Ile Gln Lys Leu Lys 
225                 230                 235                 240 


Lys Asp Arg Trp Gln Glu Arg His Ile Leu Arg Pro Tyr Leu Ala Phe 
                245                 250                 255     


Asp Ser Ile Leu Cys Glu Ala Leu Gln His Asn Leu Pro Pro Phe Thr 
            260                 265                 270         


Pro Pro Pro His Thr Glu Asp Ser Val Tyr Pro Met Pro Arg Val Ile 
        275                 280                 285             


Phe Arg Met Phe Asp Tyr Thr Asp Asp Pro Glu Gly Pro Val Met Pro 
    290                 295                 300                 


Gly Ser His Ser Val Glu Arg Phe Val Ile Glu Glu Asn Leu His Cys 
305                 310                 315                 320 


Ile Ile Lys Ser His Trp Lys Glu Arg Lys Thr Cys Ala Ala Gln Leu 
                325                 330                 335     


Val Ser Tyr Pro Gly Lys Asn Lys Ile Pro Leu Asn Tyr His Ile Val 
            340                 345                 350         


Glu Val Ile Phe Ala Glu Leu Phe Gln Leu Pro Ala Pro Pro His Ile 
        355                 360                 365             


Asp Val Met Tyr Thr Thr Leu Leu Ile Glu Leu Cys Lys Leu Gln Pro 
    370                 375                 380                 


Gly Ser Leu Pro Gln Val Leu Ala Gln Ala Thr Glu Met Leu Tyr Met 
385                 390                 395                 400 


Arg Leu Asp Thr Met Asn Thr Thr Cys Val Asp Arg Phe Ile Asn Trp 
                405                 410                 415     


Phe Ser His His Leu Ser Asn Phe Gln Phe Arg Trp Ser Trp Glu Asp 
            420                 425                 430         


Trp Ser Asp Cys Leu Ser Gln Asp Pro Glu Ser Pro Lys Pro Lys Phe 
        435                 440                 445             


Val Arg Glu Val Leu Glu Lys Cys Met Arg Leu Ser Tyr His Gln Arg 
    450                 455                 460                 


Ile Leu Asp Ile Val Pro Pro Thr Phe Ser Ala Leu Cys Pro Ala Asn 
465                 470                 475                 480 


Pro Thr Cys Ile Tyr Lys Tyr Gly Asp Glu Ser Ser Asn Ser Leu Pro 
                485                 490                 495     


Gly His Ser Val Ala Leu Cys Leu Ala Val Ala Phe Lys Ser Lys Ala 
            500                 505                 510         


Thr Asn Asp Glu Ile Phe Ser Ile Leu Lys Asp Val Pro Asn Pro Asn 
        515                 520                 525             


Gln Asp Asp Asp Asp Asp Glu Gly Phe Ser Phe Asn Pro Leu Lys Ile 
    530                 535                 540                 


Glu Val Phe Val Gln Thr Leu Leu His Leu Ala Ala Lys Ser Phe Ser 
545                 550                 555                 560 


His Ser Phe Ser Ala Leu Ala Lys Phe His Glu Val Phe Lys Thr Leu 
                565                 570                 575     


Ala Glu Ser Asp Glu Gly Lys Leu His Val Leu Arg Val Met Phe Glu 
            580                 585                 590         


Val Trp Arg Asn His Pro Gln Met Ile Ala Val Leu Val Asp Lys Met 
        595                 600                 605             


Ile Arg Thr Gln Ile Val Asp Cys Ala Ala Val Ala Asn Trp Ile Phe 
    610                 615                 620                 


Ser Ser Glu Leu Ser Arg Asp Phe Thr Arg Leu Phe Val Trp Glu Ile 
625                 630                 635                 640 


Leu His Ser Thr Ile Arg Lys Met Asn Lys His Val Leu Lys Ile Gln 
                645                 650                 655     


Lys Glu Leu Glu Glu Ala Lys Glu Lys Leu Ala Arg Gln His Lys Arg 
            660                 665                 670         


Arg Ser Asp Asp Asp Asp Arg Ser Ser Asp Arg Lys Asp Gly Val Leu 
        675                 680                 685             


Glu Glu Gln Ile Glu Arg Leu Gln Glu Lys Val Glu Ser Ala Gln Ser 
    690                 695                 700                 


Glu Gln Lys Asn Leu Phe Leu Val Ile Phe Gln Arg Phe Ile Met Ile 
705                 710                 715                 720 


Leu Thr Glu His Leu Val Arg Cys Glu Thr Asp Gly Thr Ser Val Leu 
                725                 730                 735     


Thr Pro Trp Tyr Lys Asn Cys Ile Glu Arg Leu Gln Gln Ile Phe Leu 
            740                 745                 750         


Gln His His Gln Ile Ile Gln Gln Tyr Met Val Thr Leu Glu Asn Leu 
        755                 760                 765             


Leu Phe Thr Ala Glu Leu Asp Pro His Ile Leu Ala Val Phe Gln Gln 
    770                 775                 780                 


Phe Cys Ala Leu Gln Ala 
785                 790 


<210> 6466
<211> 232
<212> PRT
<213> Homo sapiens

<400> 6466
Met Ser Gln Val Leu Ser Ile Leu Gly Met His Thr Leu Met Ser Asn 
1               5                   10                  15      


Gln Gln Tyr Tyr Gln Ala Leu Ser Ser Ser Ser Ile Met Asn Lys Glu 
            20                  25                  30          


Gly Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp 
        35                  40                  45              


Glu Glu Pro Asn Ser Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys 
    50                  55                  60                  


Asn Asn Asp Pro Lys Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn 
65                  70                  75                  80  


Ile Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ala Leu Lys Glu Asn 
                85                  90                  95      


Ser Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro 
            100                 105                 110         


Val Ala Tyr Ala Leu Ala Glu Met Leu Lys Glu Asn Lys Val Leu Lys 
        115                 120                 125             


Thr Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Arg 
    130                 135                 140                 


Leu Val Glu Ala Leu Pro Tyr Asn Thr Ser Leu Val Glu Met Lys Ile 
145                 150                 155                 160 


Asp Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val 
                165                 170                 175     


Ser Met Leu Glu Lys Asn Ala Thr Leu Leu Lys Phe Gly Tyr His Phe 
            180                 185                 190         


Thr Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn 
        195                 200                 205             


Asn Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile 
    210                 215                 220                 


Ile Pro Lys Cys Arg Ser Gly Val 
225                 230         


<210> 6467
<211> 800
<212> PRT
<213> Homo sapiens

<400> 6467
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile 
                325                 330                 335     


Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val 
            340                 345                 350         


Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe 
        355                 360                 365             


Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu 
    370                 375                 380                 


Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe 
385                 390                 395                 400 


Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His 
                405                 410                 415     


Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu 
            420                 425                 430         


Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro 
        435                 440                 445             


Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp 
    450                 455                 460                 


Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr 
465                 470                 475                 480 


Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val 
                485                 490                 495     


Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys 
            500                 505                 510         


Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His 
        515                 520                 525             


Val His Ser Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys 
    530                 535                 540                 


Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn 
545                 550                 555                 560 


Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr 
                565                 570                 575     


Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln 
            580                 585                 590         


Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln 
        595                 600                 605             


Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr 
    610                 615                 620                 


Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln 
625                 630                 635                 640 


Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp 
                645                 650                 655     


Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg 
            660                 665                 670         


Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu 
        675                 680                 685             


Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr 
    690                 695                 700                 


Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser 
705                 710                 715                 720 


Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp 
                725                 730                 735     


Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr 
            740                 745                 750         


Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp 
        755                 760                 765             


Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys 
    770                 775                 780                 


Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
785                 790                 795                 800 


<210> 6468
<211> 356
<212> PRT
<213> Homo sapiens

<400> 6468
Met Arg Arg Phe Leu Arg Pro Gly His Asp Pro Val Arg Glu Arg Leu 
1               5                   10                  15      


Lys Arg Asp Leu Phe Gln Phe Asn Lys Thr Val Glu His Gly Phe Pro 
            20                  25                  30          


His Gln Pro Ser Ala Leu Gly Tyr Ser Pro Ser Leu Arg Ile Leu Ala 
        35                  40                  45              


Ile Gly Thr Arg Ser Gly Ala Ile Lys Leu Tyr Gly Ala Pro Gly Val 
    50                  55                  60                  


Glu Phe Met Gly Leu His Gln Glu Asn Asn Ala Val Thr Gln Ile His 
65                  70                  75                  80  


Leu Leu Pro Gly Gln Cys Gln Leu Val Thr Leu Leu Asp Asp Asn Ser 
                85                  90                  95      


Leu His Leu Trp Ser Leu Lys Val Lys Gly Gly Ala Ser Glu Leu Gln 
            100                 105                 110         


Glu Asp Glu Ser Phe Thr Leu Arg Gly Pro Pro Gly Ala Ala Pro Ser 
        115                 120                 125             


Ala Thr Gln Ile Thr Val Val Leu Pro His Ser Ser Cys Glu Leu Leu 
    130                 135                 140                 


Tyr Leu Gly Thr Glu Ser Gly Asn Val Phe Val Val Gln Leu Pro Ala 
145                 150                 155                 160 


Phe Arg Ala Leu Glu Asp Arg Thr Ile Ser Ser Asp Ala Val Leu Gln 
                165                 170                 175     


Arg Leu Pro Glu Glu Ala Arg His Arg Arg Val Phe Glu Met Val Glu 
            180                 185                 190         


Ala Leu Gln Glu His Pro Arg Asp Pro Asn Gln Ile Leu Ile Gly Tyr 
        195                 200                 205             


Ser Arg Gly Leu Val Val Ile Trp Asp Leu Gln Gly Ser Arg Val Leu 
    210                 215                 220                 


Tyr His Phe Leu Ser Ser Gln Gln Leu Glu Asn Ile Trp Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Arg Leu Leu Val Ser Cys His Ser Asp Gly Ser Tyr Cys Gln 
                245                 250                 255     


Trp Pro Val Ser Ser Glu Ala Gln Gln Pro Glu Pro Leu Arg Ser Leu 
            260                 265                 270         


Val Pro Tyr Gly Pro Phe Pro Cys Lys Ala Ile Thr Arg Ile Leu Trp 
        275                 280                 285             


Leu Thr Thr Arg Gln Gly Leu Pro Phe Thr Ile Phe Gln Gly Gly Met 
    290                 295                 300                 


Pro Arg Ala Ser Tyr Gly Asp Arg His Cys Ile Ser Val Ile His Asp 
305                 310                 315                 320 


Gly Gln Gln Thr Ala Phe Asp Phe Thr Ser Arg Val Ile Gly Phe Thr 
                325                 330                 335     


Val Leu Thr Glu Ala Asp Pro Ala Ala Ser Arg Arg Ala Ser Gly Val 
            340                 345                 350         


Gly Ala Gln Gly 
        355     


<210> 6469
<211> 841
<212> PRT
<213> Homo sapiens

<400> 6469
Met Gly Ala Arg Ala Ala Gly Thr Ser Ser Gly Gly Gly Pro Arg Pro 
1               5                   10                  15      


Cys Leu Ala Arg Gly Leu Ser Ala Ser Pro Phe Pro Ala Lys Gln Gln 
            20                  25                  30          


His Pro Gln Ala Gly Ala Ser Pro Ala Glu Leu Gln Gln Arg Ala Tyr 
        35                  40                  45              


Tyr Arg Ala Arg Gln Asp Ala Ala Ser Gln Pro Gly Leu Gly Phe Leu 
    50                  55                  60                  


Ile Ser Pro Ser Ser Cys Ser Ser Trp Gly Pro Gly Ser Phe Thr Arg 
65                  70                  75                  80  


Ser Cys Gly Tyr Pro Thr Leu Cys Ser Ser Trp Ile Ser Lys Arg Glu 
                85                  90                  95      


Pro Gly Glu Leu Ser Gly Val Trp Thr Ser Ala Trp Arg Thr His Ala 
            100                 105                 110         


Ala Phe Thr Gly Ser Gln Asp Leu Cys Leu Tyr Lys Gly Leu Gly Ser 
        115                 120                 125             


Ile Tyr Glu Asp Lys Thr Ala Leu Ser Leu Leu Gly Leu Gly Glu Glu 
    130                 135                 140                 


Thr Asn Glu Glu Asp Glu Glu Glu Ser Asp Asn Gln Ser Val His Ser 
145                 150                 155                 160 


Ser Ser Glu Pro Leu Arg Asn Leu His Leu Asp Ile Gly Ala Leu Gly 
                165                 170                 175     


Gly Asp Phe Glu Tyr Glu Glu Ser Leu Arg Thr Ser Gln Pro Glu Glu 
            180                 185                 190         


Lys Lys Asp Val Ser Leu Asp Ser Asp Ala Ala Gly Pro Pro Thr Pro 
        195                 200                 205             


Cys Lys Pro Ser Ser Pro Gly Ala Asp Ser Ser Leu Ser Ser Ala Val 
    210                 215                 220                 


Gly Lys Gly Arg Gln Gly Ser Gly Ala Arg Pro Gly Leu Pro Glu Lys 
225                 230                 235                 240 


Glu Glu Asn Glu Lys Ser Glu Pro Lys Ile Cys Arg Asn Leu Val Thr 
                245                 250                 255     


Pro Lys Ala Asp Pro Thr Gly Ser Glu Pro Ala Lys Ala Ser Glu Lys 
            260                 265                 270         


Glu Ala Pro Glu Asp Thr Val Asp Ala Gly Glu Glu Gly Ser Arg Arg 
        275                 280                 285             


Glu Glu Ala Ala Lys Glu Pro Lys Lys Lys Ala Ser Ala Leu Glu Glu 
    290                 295                 300                 


Gly Ser Ser Asp Ala Ser Gln Glu Leu Glu Ile Ser Glu His Met Lys 
305                 310                 315                 320 


Glu Pro Gln Leu Ser Asp Ser Ile Ala Ser Asp Pro Lys Ser Phe His 
                325                 330                 335     


Gly Leu Asp Phe Gly Phe Arg Ser Arg Ile Ser Glu His Leu Leu Asp 
            340                 345                 350         


Val Asp Val Leu Ser Pro Val Leu Gly Gly Ala Cys Arg Gln Ala Gln 
        355                 360                 365             


Gln Pro Leu Gly Ile Glu Asp Lys Asp Asp Ser Gln Ser Ser Gln Asp 
    370                 375                 380                 


Glu Leu Gln Ser Lys Gln Ser Lys Gly Leu Glu Glu Arg Tyr His Arg 
385                 390                 395                 400 


Leu Ser Pro Pro Leu Pro His Glu Glu Arg Ala Gln Ser Pro Pro Arg 
                405                 410                 415     


Ser Leu Ala Thr Glu Glu Glu Pro Pro Gln Gly Pro Glu Gly Gln Pro 
            420                 425                 430         


Glu Trp Lys Glu Ala Glu Glu Leu Gly Glu Asp Ser Ala Ala Ser Leu 
        435                 440                 445             


Ser Leu Gln Leu Ser Leu Gln Arg Arg Ser Thr Glu Pro Val Ala Pro 
    450                 455                 460                 


Pro Glu Gln Leu Ser Glu Ala Ala Leu Lys Ala Met Glu Glu Ala Val 
465                 470                 475                 480 


Ala Gln Val Leu Glu Gln Asp Gln Arg His Leu Leu Glu Ser Lys Gln 
                485                 490                 495     


Glu Lys Met Gln Gln Leu Arg Glu Lys Leu Cys Gln Glu Glu Glu Glu 
            500                 505                 510         


Glu Ile Leu Arg Leu His Gln Gln Lys Glu Gln Ser Leu Ser Ser Leu 
        515                 520                 525             


Arg Glu Arg Leu Gln Lys Ala Ile Glu Glu Glu Glu Ala Arg Met Arg 
    530                 535                 540                 


Glu Glu Glu Ser Gln Arg Leu Ser Trp Leu Arg Ala Gln Val Gln Ser 
545                 550                 555                 560 


Ser Thr Gln Ala Asp Glu Asp Gln Ile Arg Ala Glu Gln Glu Ala Ser 
                565                 570                 575     


Leu Gln Lys Leu Arg Glu Glu Leu Glu Ser Gln Gln Lys Ala Glu Arg 
            580                 585                 590         


Ala Ser Leu Glu Gln Lys Asn Arg Gln Met Leu Glu Gln Leu Lys Glu 
        595                 600                 605             


Glu Ile Glu Ala Ser Glu Lys Ser Glu Gln Ala Ala Leu Asn Ala Ala 
    610                 615                 620                 


Lys Glu Lys Ala Leu Gln Gln Leu Arg Glu Gln Leu Glu Gly Glu Arg 
625                 630                 635                 640 


Lys Glu Ala Val Ala Thr Leu Glu Lys Glu His Ser Ala Glu Leu Glu 
                645                 650                 655     


Arg Leu Cys Ser Ser Leu Glu Ala Lys His Arg Glu Val Val Ser Ser 
            660                 665                 670         


Leu Gln Lys Lys Ile Gln Glu Ala Gln Gln Lys Glu Glu Ala Gln Leu 
        675                 680                 685             


Gln Lys Cys Leu Gly Gln Val Glu His Arg Val His Gln Lys Ser Tyr 
    690                 695                 700                 


His Val Ala Gly Tyr Glu His Glu Leu Ser Ser Leu Leu Arg Glu Lys 
705                 710                 715                 720 


Arg Gln Glu Val Glu Gly Glu His Glu Arg Arg Leu Asp Lys Met Lys 
                725                 730                 735     


Glu Glu His Gln Gln Val Met Ala Lys Ala Arg Glu Gln Tyr Glu Ala 
            740                 745                 750         


Glu Glu Arg Lys Gln Arg Ala Glu Leu Leu Gly His Leu Thr Gly Glu 
        755                 760                 765             


Leu Glu Arg Leu Gln Arg Ala His Glu Arg Glu Leu Glu Thr Val Arg 
    770                 775                 780                 


Gln Glu Gln His Lys Arg Leu Glu Asp Leu Arg Arg Arg His Arg Glu 
785                 790                 795                 800 


Gln Glu Arg Lys Leu Gln Asp Leu Glu Leu Asp Leu Glu Thr Arg Ala 
                805                 810                 815     


Lys Asp Val Lys Ala Arg Leu Ala Leu Leu Glu Val Gln Val Arg Asp 
            820                 825                 830         


Leu Gln Glu Ser Leu Thr Ser Glu Ser 
        835                 840     


<210> 6470
<211> 350
<212> PRT
<213> Homo sapiens

<400> 6470
Met Ile Arg Gly Phe Glu Ala Pro Met Ala Glu Asn Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Val Ile Phe Cys His Asp Ser Pro Lys Arg Val Leu Val 
            20                  25                  30          


Ser Val Ile Arg Thr Thr Pro Ile Lys Pro Thr Cys Gly Gly Gly Gly 
        35                  40                  45              


Glu Pro Glu Pro Pro Pro Pro Leu Ile Pro Thr Ser Pro Gly Phe Ser 
    50                  55                  60                  


Asp Phe Met Val Tyr Pro Trp Arg Trp Gly Glu Asn Ala His Asn Val 
65                  70                  75                  80  


Thr Leu Ser Pro Gly Ala Ala Gly Ala Ala Ala Ser Ala Ala Leu Pro 
                85                  90                  95      


Ala Ala Ala Ala Ala Glu His Ser Gly Leu Arg Gly Arg Gly Ala Pro 
            100                 105                 110         


Pro Pro Ala Ala Ser Ala Ser Ala Ala Ala Ser Gly Gly Glu Asp Glu 
        115                 120                 125             


Glu Glu Ala Ser Ser Pro Asp Ser Gly His Leu Lys Asp Gly Ile Arg 
    130                 135                 140                 


Arg Gly Arg Pro Arg Ala Asp Thr Val Arg Asp Leu Ile Asn Glu Gly 
145                 150                 155                 160 


Glu His Ser Ser Ser Arg Ile Arg Cys Asn Ile Cys Asn Arg Val Phe 
                165                 170                 175     


Pro Arg Glu Lys Ser Leu Gln Ala His Lys Arg Thr His Thr Gly Glu 
            180                 185                 190         


Arg Pro Tyr Leu Cys Asp Tyr Pro Asp Cys Gly Lys Ala Phe Val Gln 
        195                 200                 205             


Ser Gly Gln Leu Lys Thr His Gln Arg Leu His Thr Gly Glu Lys Pro 
    210                 215                 220                 


Phe Val Cys Ser Glu Asn Gly Cys Leu Ser Arg Phe Thr His Ala Asn 
225                 230                 235                 240 


Arg His Cys Pro Lys His Pro Tyr Ala Arg Leu Lys Arg Glu Glu Pro 
                245                 250                 255     


Thr Asp Thr Leu Ser Lys His Gln Ala Ala Asp Asn Lys Ala Ala Ala 
            260                 265                 270         


Glu Trp Leu Ala Arg Tyr Trp Glu Met Arg Glu Gln Arg Thr Pro Thr 
        275                 280                 285             


Leu Lys Gly Lys Leu Val Gln Lys Ala Asp Gln Glu Gln Gln Asp Pro 
    290                 295                 300                 


Leu Glu Tyr Leu Gln Ser Asp Glu Glu Asp Asp Glu Lys Arg Gly Ala 
305                 310                 315                 320 


Gln Arg Arg Leu Gln Glu Gln Arg Glu Arg Leu His Gly Ala Leu Ala 
                325                 330                 335     


Leu Ile Glu Leu Ala Asn Leu Thr Gly Ala Pro Leu Arg Gln 
            340                 345                 350 


<210> 6471
<211> 378
<212> PRT
<213> Homo sapiens

<400> 6471
Met Asn Met Ile Trp Arg Asn Ser Ile Ser Cys Leu Arg Leu Gly Lys 
1               5                   10                  15      


Val Pro His Arg Tyr Gln Ser Gly Tyr His Pro Val Ala Pro Leu Gly 
            20                  25                  30          


Ser Arg Ile Leu Thr Asp Pro Ala Lys Val Phe Glu His Asn Met Trp 
        35                  40                  45              


Asp His Met Gln Trp Ser Lys Glu Glu Glu Ala Ala Ala Arg Lys Lys 
    50                  55                  60                  


Val Lys Glu Asn Ser Ala Val Arg Val Leu Leu Glu Glu Gln Val Lys 
65                  70                  75                  80  


Tyr Glu Arg Glu Ala Ser Lys Tyr Trp Asp Thr Phe Tyr Lys Ile His 
                85                  90                  95      


Lys Asn Lys Phe Phe Lys Asp Arg Asn Trp Leu Leu Arg Glu Phe Pro 
            100                 105                 110         


Glu Ile Leu Pro Val Asp Gln Lys Pro Glu Glu Lys Ala Arg Glu Ser 
        115                 120                 125             


Ser Trp Asp His Val Lys Thr Ser Ala Thr Asn Arg Phe Ser Arg Met 
    130                 135                 140                 


His Cys Pro Thr Val Pro Asp Glu Lys Asn His Tyr Glu Lys Ser Ser 
145                 150                 155                 160 


Gly Ser Ser Glu Gly Gln Ser Lys Thr Glu Ser Asp Phe Ser Asn Leu 
                165                 170                 175     


Asp Ser Glu Lys His Lys Lys Gly Pro Met Glu Thr Gly Leu Phe Pro 
            180                 185                 190         


Gly Ser Asn Ala Thr Phe Arg Ile Leu Glu Val Gly Cys Gly Ala Gly 
        195                 200                 205             


Asn Ser Val Phe Pro Ile Leu Asn Thr Leu Glu Asn Ser Pro Glu Ser 
    210                 215                 220                 


Phe Leu Tyr Cys Cys Asp Phe Ala Ser Gly Ala Val Glu Leu Val Lys 
225                 230                 235                 240 


Ser His Ser Ser Tyr Arg Ala Thr Gln Cys Phe Ala Phe Val His Asp 
                245                 250                 255     


Val Cys Asp Asp Gly Leu Pro Tyr Pro Phe Pro Asp Gly Ile Leu Asp 
            260                 265                 270         


Val Ile Leu Leu Val Phe Val Leu Ser Ser Ile His Pro Asp Arg Met 
        275                 280                 285             


Gln Gly Val Val Asn Arg Leu Ser Lys Leu Leu Lys Pro Gly Gly Met 
    290                 295                 300                 


Leu Leu Phe Arg Asp Tyr Gly Arg Tyr Asp Lys Thr Gln Leu Arg Phe 
305                 310                 315                 320 


Lys Lys Gly His Cys Leu Ser Glu Asn Phe Tyr Val Arg Gly Asp Gly 
                325                 330                 335     


Thr Arg Ala Tyr Phe Phe Thr Lys Gly Glu Val His Ser Met Phe Cys 
            340                 345                 350         


Lys Ala Ser Leu Asp Glu Lys Gln Asn Leu Val Asp Arg Arg Leu Gln 
        355                 360                 365             


Val Asn Arg Lys Lys Gln Val Lys Met His 
    370                 375             


<210> 6472
<211> 598
<212> PRT
<213> Homo sapiens

<400> 6472
Met Gly Leu Arg Ala Ser Arg Pro Ser Lys Leu Thr Trp Lys Lys Trp 
1               5                   10                  15      


Ala Thr Thr Ala Ala Ser Asn Ser Cys Ser Arg Ser Val Ser Ser Cys 
            20                  25                  30          


Arg Arg Cys Thr Gly Gly Arg Leu Met Lys Glu Pro Trp Arg Arg Pro 
        35                  40                  45              


Ser Ser Ser Ile Cys Tyr Thr Ser Arg Ser Ser Thr Ile Lys Phe Ser 
    50                  55                  60                  


Ser Asn Lys Phe Lys Thr Leu Ser Val Leu Leu Ser His Leu His Leu 
65                  70                  75                  80  


Phe Arg Leu His Val Lys Ile Ser Gln Pro Ser Leu Pro Ile Ser Ser 
                85                  90                  95      


Arg Gly Ala Ala Ser Ser Ser Gln Phe Gln Gly Leu Pro Ser Arg Ser 
            100                 105                 110         


Ala Ile Phe Gln Gln Gln Pro Glu Asn Cys Ser Ser Pro Pro Asn Val 
        115                 120                 125             


Ala Leu Thr Cys Leu Gly Met Gln Gln Pro Ala Gln Ser Gln Gln Val 
    130                 135                 140                 


Thr Ile Gln Val Gln Glu Pro Val Asp Met Leu Ser Asn Met Pro Gly 
145                 150                 155                 160 


Thr Ala Ala Gly Ser Ser Gly Arg Gly Ile Ser Ile Ser Pro Ser Ala 
                165                 170                 175     


Gly Gln Met Gln Met Gln His Arg Thr Asn Leu Met Ala Thr Leu Ser 
            180                 185                 190         


Tyr Gly His Arg Pro Leu Ser Lys Gln Leu Ser Ala Asp Ser Ala Glu 
        195                 200                 205             


Ala His Ser Ala His Gln Gln Pro Pro His Tyr Thr Thr Ser Ala Leu 
    210                 215                 220                 


Gln Gln Ala Leu Leu Ser Pro Thr Pro Pro Asp Tyr Thr Arg His Gln 
225                 230                 235                 240 


Gln Val Pro His Ile Leu Gln Gly Leu Leu Ser Pro Arg His Ser Leu 
                245                 250                 255     


Thr Gly His Ser Asp Ile Arg Leu Pro Pro Thr Glu Phe Ala Gln Leu 
            260                 265                 270         


Ile Lys Arg Gln Gln Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Glu Tyr Gln Glu Leu Phe Arg His Met Asn Gln Gly Asp Ala 
    290                 295                 300                 


Gly Ser Leu Ala Pro Ser Leu Gly Gly Gln Ser Met Thr Glu Arg Gln 
305                 310                 315                 320 


Ala Leu Ser Tyr Gln Asn Ala Asp Ser Tyr His His His Thr Ser Pro 
                325                 330                 335     


Gln His Leu Leu Gln Ile Arg Ala Gln Glu Cys Val Ser Gln Ala Ser 
            340                 345                 350         


Ser Pro Thr Pro Pro His Gly Tyr Ala His Gln Pro Ala Leu Met His 
        355                 360                 365             


Ser Glu Ser Met Glu Glu Asp Cys Ser Cys Glu Gly Ala Lys Asp Gly 
    370                 375                 380                 


Phe Gln Asp Ser Lys Ser Ser Ser Thr Leu Thr Lys Gly Cys His Asp 
385                 390                 395                 400 


Ser Pro Leu Leu Leu Ser Thr Gly Gly Pro Gly Asp Pro Glu Ser Leu 
                405                 410                 415     


Leu Gly Thr Val Ser His Ala Gln Glu Leu Gly Ile His Pro Tyr Gly 
            420                 425                 430         


His Gln Pro Thr Ala Ala Phe Ser Lys Asn Lys Val Pro Ser Arg Glu 
        435                 440                 445             


Pro Val Ile Gly Asn Cys Met Asp Arg Ser Ser Pro Gly Gln Ala Val 
    450                 455                 460                 


Glu Leu Pro Asp His Asn Gly Leu Gly Tyr Pro Ala Arg Pro Ser Val 
465                 470                 475                 480 


His Glu His His Arg Pro Arg Ala Leu Gln Arg His His Thr Ile Gln 
                485                 490                 495     


Asn Ser Asp Asp Ala Tyr Val Gln Leu Asp Asn Leu Pro Gly Met Ser 
            500                 505                 510         


Leu Val Ala Gly Lys Ala Leu Ser Ser Ala Arg Met Ser Asp Ala Val 
        515                 520                 525             


Leu Ser Gln Ser Ser Leu Met Gly Ser Gln Gln Phe Gln Asp Gly Glu 
    530                 535                 540                 


Asn Glu Glu Cys Gly Ala Ser Leu Gly Gly His Glu His Pro Asp Leu 
545                 550                 555                 560 


Ser Asp Gly Ser Gln His Leu Asn Ser Ser Cys Tyr Pro Ser Thr Cys 
                565                 570                 575     


Ile Thr Asp Ile Leu Leu Ser Tyr Lys His Pro Glu Val Ser Phe Ser 
            580                 585                 590         


Met Glu Gln Ala Gly Val 
        595             


<210> 6473
<211> 1321
<212> PRT
<213> Homo sapiens

<400> 6473
Met Ala Ala Ala Ala Ala Ser Gly Ala Gly Gly Ala Ala Gly Ala Gly 
1               5                   10                  15      


Thr Gly Gly Ala Gly Pro Ala Gly Arg Leu Leu Pro Pro Pro Ala Pro 
            20                  25                  30          


Gly Ser Pro Ala Ala Pro Ala Ala Val Ser Pro Ala Ala Gly Gln Pro 
        35                  40                  45              


Arg Pro Pro Ala Pro Ala Ser Arg Gly Pro Met Pro Ala Arg Ile Gly 
    50                  55                  60                  


Tyr Tyr Glu Ile Asp Arg Thr Ile Gly Lys Gly Asn Phe Ala Val Val 
65                  70                  75                  80  


Lys Arg Ala Thr His Leu Val Thr Lys Ala Lys Val Ala Ile Lys Ile 
                85                  90                  95      


Ile Asp Lys Thr Gln Leu Asp Glu Glu Asn Leu Lys Lys Ile Phe Arg 
            100                 105                 110         


Glu Val Gln Ile Met Lys Met Leu Cys His Pro His Ile Ile Arg Leu 
        115                 120                 125             


Tyr Gln Val Met Glu Thr Glu Arg Met Ile Tyr Leu Val Thr Glu Tyr 
    130                 135                 140                 


Ala Ser Gly Gly Glu Ile Phe Asp His Leu Val Ala His Gly Arg Met 
145                 150                 155                 160 


Ala Glu Lys Glu Ala Arg Arg Lys Phe Lys Gln Ile Val Thr Ala Val 
                165                 170                 175     


Tyr Phe Cys His Cys Arg Asn Ile Val His Arg Asp Leu Lys Ala Glu 
            180                 185                 190         


Asn Leu Leu Leu Asp Ala Asn Leu Asn Ile Lys Ile Ala Asp Phe Gly 
        195                 200                 205             


Phe Ser Asn Leu Phe Thr Pro Gly Gln Leu Leu Lys Thr Trp Cys Gly 
    210                 215                 220                 


Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe Glu Gly Lys Glu Tyr Asp 
225                 230                 235                 240 


Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Val Val Leu Tyr Val Leu 
                245                 250                 255     


Val Cys Gly Ala Leu Pro Phe Asp Gly Ser Thr Leu Gln Asn Leu Arg 
            260                 265                 270         


Ala Arg Val Leu Ser Gly Lys Phe Arg Ile Pro Phe Phe Met Ser Thr 
        275                 280                 285             


Glu Cys Glu His Leu Ile Arg His Met Leu Val Leu Asp Pro Asn Lys 
    290                 295                 300                 


Arg Leu Ser Met Glu Gln Ile Cys Lys His Lys Trp Met Lys Leu Gly 
305                 310                 315                 320 


Asp Ala Asp Pro Asn Phe Asp Arg Leu Ile Ala Glu Cys Gln Gln Leu 
                325                 330                 335     


Lys Glu Glu Arg Gln Val Asp Pro Leu Asn Glu Asp Val Leu Leu Ala 
            340                 345                 350         


Met Glu Asp Met Gly Leu Asp Lys Glu Gln Thr Leu Gln Ser Leu Arg 
        355                 360                 365             


Ser Asp Ala Tyr Asp His Tyr Ser Ala Ile Tyr Ser Leu Leu Cys Asp 
    370                 375                 380                 


Arg His Lys Arg His Lys Thr Leu Arg Leu Gly Ala Leu Pro Ser Met 
385                 390                 395                 400 


Pro Arg Ala Leu Ala Phe Gln Ala Pro Val Asn Ile Gln Ala Glu Gln 
                405                 410                 415     


Ala Gly Thr Ala Met Asn Ile Ser Val Pro Gln Val Gln Leu Ile Asn 
            420                 425                 430         


Pro Glu Asn Gln Ile Val Glu Pro Asp Gly Thr Leu Asn Leu Asp Ser 
        435                 440                 445             


Asp Glu Gly Glu Glu Pro Ser Pro Glu Ala Leu Val Arg Tyr Leu Ser 
    450                 455                 460                 


Met Arg Arg His Thr Val Gly Val Ala Asp Pro Arg Thr Glu Val Met 
465                 470                 475                 480 


Glu Asp Leu Gln Lys Leu Leu Pro Gly Phe Pro Gly Val Asn Pro Gln 
                485                 490                 495     


Ala Pro Phe Leu Gln Val Ala Pro Asn Val Asn Phe Met His Asn Leu 
            500                 505                 510         


Leu Pro Met Gln Asn Leu Gln Pro Thr Gly Gln Leu Glu Tyr Lys Glu 
        515                 520                 525             


Gln Ser Leu Leu Gln Pro Pro Thr Leu Gln Leu Leu Asn Gly Met Gly 
    530                 535                 540                 


Pro Leu Gly Arg Arg Ala Ser Asp Gly Gly Ala Asn Ile Gln Leu His 
545                 550                 555                 560 


Ala Gln Gln Leu Leu Lys Arg Pro Arg Gly Pro Ser Pro Leu Val Thr 
                565                 570                 575     


Met Thr Pro Ala Val Pro Ala Val Thr Pro Val Asp Glu Glu Ser Ser 
            580                 585                 590         


Asp Gly Glu Pro Asp Gln Glu Ala Val Gln Ser Ser Thr Tyr Lys Asp 
        595                 600                 605             


Ser Asn Thr Leu His Leu Pro Thr Glu Arg Phe Ser Pro Val Arg Arg 
    610                 615                 620                 


Phe Ser Asp Gly Ala Ala Ser Ile Gln Ala Phe Lys Ala His Leu Glu 
625                 630                 635                 640 


Lys Met Gly Asn Asn Ser Ser Ile Lys Gln Leu Gln Gln Glu Cys Glu 
                645                 650                 655     


Gln Leu Gln Lys Met Tyr Gly Gly Gln Ile Asp Glu Arg Thr Leu Glu 
            660                 665                 670         


Lys Thr Gln Gln Gln His Met Leu Tyr Gln Gln Glu Gln His His Gln 
        675                 680                 685             


Ile Leu Gln Gln Gln Ile Gln Asp Ser Ile Cys Pro Pro Gln Pro Ser 
    690                 695                 700                 


Pro Pro Leu Gln Ala Ala Cys Glu Asn Gln Pro Ala Leu Leu Thr His 
705                 710                 715                 720 


Gln Leu Gln Arg Leu Arg Ile Gln Pro Ser Ser Pro Pro Pro Asn His 
                725                 730                 735     


Pro Asn Asn His Leu Phe Arg Gln Pro Ser Asn Ser Pro Pro Pro Met 
            740                 745                 750         


Ser Ser Ala Met Ile Gln Pro His Gly Ala Ala Ser Ser Ser Gln Phe 
        755                 760                 765             


Gln Gly Leu Pro Ser Arg Ser Ala Ile Phe Gln Gln Gln Pro Glu Asn 
    770                 775                 780                 


Cys Ser Ser Pro Pro Asn Val Ala Leu Thr Cys Leu Gly Met Gln Gln 
785                 790                 795                 800 


Pro Ala Gln Ser Gln Gln Val Thr Ile Gln Val Gln Glu Pro Val Asp 
                805                 810                 815     


Met Leu Ser Asn Met Pro Gly Thr Ala Ala Gly Ser Ser Gly Arg Gly 
            820                 825                 830         


Ile Ser Ile Ser Pro Ser Ala Gly Gln Met Gln Met Gln His Arg Thr 
        835                 840                 845             


Asn Leu Met Ala Thr Leu Ser Tyr Gly His Arg Pro Leu Ser Lys Gln 
    850                 855                 860                 


Leu Ser Ala Asp Ser Ala Glu Ala His Ser Leu Asn Val Asn Arg Phe 
865                 870                 875                 880 


Ser Pro Ala Asn Tyr Asp Gln Ala His Leu His Pro His Leu Phe Ser 
                885                 890                 895     


Asp Gln Ser Arg Gly Ser Pro Ser Ser Tyr Ser Pro Ser Thr Gly Val 
            900                 905                 910         


Gly Phe Ser Pro Thr Gln Ala Leu Lys Val Pro Pro Leu Asp Gln Phe 
        915                 920                 925             


Pro Thr Phe Pro Pro Ser Ala His Gln Gln Pro Pro His Tyr Thr Thr 
    930                 935                 940                 


Ser Ala Leu Gln Gln Ala Leu Leu Ser Pro Thr Pro Pro Asp Tyr Thr 
945                 950                 955                 960 


Arg His Gln Gln Val Pro His Ile Leu Gln Gly Leu Leu Ser Pro Arg 
                965                 970                 975     


His Ser Leu Thr Gly His Ser Asp Ile Arg Leu Pro Pro Thr Glu Phe 
            980                 985                 990         


Ala Gln Leu Ile Lys Arg Gln Gln  Gln Gln Arg Gln Gln  Gln Gln Gln 
        995                 1000                 1005             


Gln Gln  Gln Gln Gln Glu Tyr  Gln Glu Leu Phe Arg  His Met Asn 
    1010                 1015                 1020             


Gln Gly  Asp Ala Gly Ser Leu  Ala Pro Ser Leu Gly  Gly Gln Ser 
    1025                 1030                 1035             


Met Thr  Glu Arg Gln Ala Leu  Ser Tyr Gln Asn Ala  Asp Ser Tyr 
    1040                 1045                 1050             


His His  His Thr Ser Pro Gln  His Leu Leu Gln Ile  Arg Ala Gln 
    1055                 1060                 1065             


Glu Cys  Val Ser Gln Ala Ser  Ser Pro Thr Pro Pro  His Gly Tyr 
    1070                 1075                 1080             


Ala His  Gln Pro Ala Leu Met  His Ser Glu Ser Met  Glu Glu Asp 
    1085                 1090                 1095             


Cys Ser  Cys Glu Gly Ala Lys  Asp Gly Phe Gln Asp  Ser Lys Ser 
    1100                 1105                 1110             


Ser Ser  Thr Leu Thr Lys Gly  Cys His Asp Ser Pro  Leu Leu Leu 
    1115                 1120                 1125             


Ser Thr  Gly Gly Pro Gly Asp  Pro Glu Ser Leu Leu  Gly Thr Val 
    1130                 1135                 1140             


Ser His  Ala Gln Glu Leu Gly  Ile His Pro Tyr Gly  His Gln Pro 
    1145                 1150                 1155             


Thr Ala  Ala Phe Ser Lys Asn  Lys Val Pro Ser Arg  Glu Pro Val 
    1160                 1165                 1170             


Ile Gly  Asn Cys Met Asp Arg  Ser Ser Pro Gly Gln  Ala Val Glu 
    1175                 1180                 1185             


Leu Pro  Asp His Asn Gly Leu  Gly Tyr Pro Ala Arg  Pro Ser Val 
    1190                 1195                 1200             


His Glu  His His Arg Pro Arg  Ala Leu Gln Arg His  His Thr Ile 
    1205                 1210                 1215             


Gln Asn  Ser Asp Asp Ala Tyr  Val Gln Leu Asp Asn  Leu Pro Gly 
    1220                 1225                 1230             


Met Ser  Leu Val Ala Gly Lys  Ala Leu Ser Ser Ala  Arg Met Ser 
    1235                 1240                 1245             


Asp Ala  Val Leu Ser Gln Ser  Ser Leu Met Gly Ser  Gln Gln Phe 
    1250                 1255                 1260             


Gln Asp  Gly Glu Asn Glu Glu  Cys Gly Ala Ser Leu  Gly Gly His 
    1265                 1270                 1275             


Glu His  Pro Asp Leu Ser Asp  Gly Ser Gln His Leu  Asn Ser Ser 
    1280                 1285                 1290             


Cys Tyr  Pro Ser Thr Cys Ile  Thr Asp Ile Leu Leu  Ser Tyr Lys 
    1295                 1300                 1305             


His Pro  Glu Val Ser Phe Ser  Met Glu Gln Ala Gly  Val 
    1310                 1315                 1320     


<210> 6474
<211> 522
<212> PRT
<213> Homo sapiens

<400> 6474
Met Pro Arg Lys Lys Ala Ala Ala Ala Ala Trp Glu Glu Pro Ser Ser 
1               5                   10                  15      


Gly Asn Gly Thr Ala Arg Ala Gly Pro Arg Lys Arg Gly Gly Pro Ala 
            20                  25                  30          


Gly Arg Lys Arg Glu Arg Pro Glu Arg Cys Ser Ser Ser Ser Gly Gly 
        35                  40                  45              


Gly Ser Ser Gly Asp Glu Asp Gly Leu Glu Leu Asp Gly Ala Pro Gly 
    50                  55                  60                  


Gly Gly Lys Arg Ala Ala Arg Pro Ala Thr Ala Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Ala Ala Val Val Ile Thr Glu Pro Glu His Thr Lys Glu Arg Val Lys 
                85                  90                  95      


Leu Glu Gly Ser Lys Cys Lys Gly Gln Leu Leu Ile Phe Gly Ala Thr 
            100                 105                 110         


Asn Trp Asp Leu Ile Gly Arg Lys Glu Val Pro Lys Gln Gln Ala Ala 
        115                 120                 125             


Tyr Arg Asn Leu Gly Gln Asn Leu Trp Gly Pro His Arg Tyr Gly Cys 
    130                 135                 140                 


Leu Ala Gly Val Arg Val Arg Thr Val Val Ser Gly Ser Cys Ala Ala 
145                 150                 155                 160 


His Ser Leu Leu Ile Thr Thr Glu Gly Lys Leu Trp Ser Trp Gly Arg 
                165                 170                 175     


Asn Glu Lys Gly Gln Leu Gly His Gly Asp Thr Lys Arg Val Glu Ala 
            180                 185                 190         


Pro Arg Leu Ile Glu Gly Leu Ser His Glu Val Ile Val Ser Ala Ala 
        195                 200                 205             


Cys Gly Arg Asn His Thr Leu Ala Leu Thr Glu Thr Gly Ser Val Phe 
    210                 215                 220                 


Ala Phe Gly Glu Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr 
225                 230                 235                 240 


Asp Ala Val Pro Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile 
                245                 250                 255     


Thr Lys Met Ala Cys Gly Ala Glu Phe Ser Met Ile Met Asp Cys Lys 
            260                 265                 270         


Gly Asn Leu Tyr Ser Phe Gly Cys Pro Glu Tyr Gly Gln Leu Gly His 
        275                 280                 285             


Asn Ser Asp Gly Lys Phe Ile Ala Arg Ala Gln Arg Ile Glu Tyr Asp 
    290                 295                 300                 


Cys Glu Leu Val Pro Arg Arg Val Ala Ile Phe Ile Glu Lys Thr Lys 
305                 310                 315                 320 


Asp Gly Gln Ile Leu Pro Val Pro Asn Val Val Val Arg Asp Val Ala 
                325                 330                 335     


Cys Gly Ala Asn His Thr Leu Val Leu Asp Ser Gln Lys Arg Val Phe 
            340                 345                 350         


Ser Trp Gly Phe Gly Gly Tyr Gly Arg Leu Gly His Ala Glu Gln Lys 
        355                 360                 365             


Asp Glu Met Val Pro Arg Leu Val Lys Leu Phe Asp Phe Pro Gly Arg 
    370                 375                 380                 


Gly Ala Ser Gln Ile Tyr Ala Gly Tyr Thr Cys Ser Phe Ala Val Ser 
385                 390                 395                 400 


Glu Val Gly Gly Leu Phe Phe Trp Gly Ala Thr Asn Thr Ser Arg Glu 
                405                 410                 415     


Ser Thr Met Tyr Pro Lys Ala Val Gln Asp Leu Cys Gly Trp Arg Ile 
            420                 425                 430         


Arg Ser Leu Ala Cys Gly Lys Ser Ser Ile Ile Val Ala Ala Asp Glu 
        435                 440                 445             


Ser Thr Ile Ser Trp Gly Pro Ser Pro Thr Phe Gly Glu Leu Gly Tyr 
    450                 455                 460                 


Gly Asp His Lys Pro Lys Ser Ser Thr Ala Ala Gln Glu Val Lys Thr 
465                 470                 475                 480 


Leu Asp Gly Ile Phe Ser Glu Gln Val Ala Met Gly Tyr Ser His Ser 
                485                 490                 495     


Leu Val Ile Ala Arg Asp Glu Ser Glu Thr Glu Lys Glu Lys Ile Lys 
            500                 505                 510         


Lys Leu Pro Glu Tyr Asn Pro Arg Thr Leu 
        515                 520         


<210> 6475
<211> 522
<212> PRT
<213> Homo sapiens

<400> 6475
Met Pro Arg Lys Lys Ala Ala Ala Ala Ala Trp Glu Glu Pro Ser Ser 
1               5                   10                  15      


Gly Asn Gly Thr Ala Arg Ala Gly Pro Arg Lys Arg Gly Gly Pro Ala 
            20                  25                  30          


Gly Arg Lys Arg Glu Arg Pro Glu Arg Cys Ser Ser Ser Ser Gly Gly 
        35                  40                  45              


Gly Ser Ser Gly Asp Glu Asp Gly Leu Glu Leu Asp Gly Ala Pro Gly 
    50                  55                  60                  


Gly Gly Lys Arg Ala Ala Arg Pro Ala Thr Ala Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Ala Ala Val Val Ile Thr Glu Pro Glu His Thr Lys Glu Arg Val Lys 
                85                  90                  95      


Leu Glu Gly Ser Lys Cys Lys Gly Gln Leu Leu Ile Phe Gly Ala Thr 
            100                 105                 110         


Asn Trp Asp Leu Ile Gly Arg Lys Glu Val Pro Lys Gln Gln Ala Ala 
        115                 120                 125             


Tyr Arg Asn Leu Gly Gln Asn Leu Trp Gly Pro His Arg Tyr Gly Cys 
    130                 135                 140                 


Leu Ala Gly Val Arg Val Arg Thr Val Val Ser Gly Ser Cys Ala Ala 
145                 150                 155                 160 


His Ser Leu Leu Ile Thr Thr Glu Gly Lys Leu Trp Ser Trp Gly Arg 
                165                 170                 175     


Asn Glu Lys Gly Gln Leu Gly His Gly Asp Thr Lys Arg Val Glu Ala 
            180                 185                 190         


Pro Arg Leu Ile Glu Gly Leu Ser His Glu Val Ile Val Ser Ala Ala 
        195                 200                 205             


Cys Gly Arg Asn His Thr Leu Ala Leu Thr Glu Thr Gly Ser Val Phe 
    210                 215                 220                 


Ala Phe Gly Glu Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr 
225                 230                 235                 240 


Asp Ala Val Pro Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile 
                245                 250                 255     


Thr Lys Met Ala Cys Gly Ala Glu Phe Ser Met Ile Met Asp Cys Lys 
            260                 265                 270         


Gly Asn Leu Tyr Ser Phe Gly Cys Pro Glu Tyr Gly Gln Leu Gly His 
        275                 280                 285             


Asn Ser Asp Gly Lys Phe Ile Ala Arg Ala Gln Arg Ile Glu Tyr Asp 
    290                 295                 300                 


Cys Glu Leu Val Pro Arg Arg Val Ala Ile Phe Ile Glu Lys Thr Lys 
305                 310                 315                 320 


Asp Gly Gln Ile Leu Pro Val Pro Asn Val Val Val Arg Asp Val Ala 
                325                 330                 335     


Cys Gly Ala Asn His Thr Leu Val Leu Asp Ser Gln Lys Arg Val Phe 
            340                 345                 350         


Ser Trp Gly Phe Gly Gly Tyr Gly Arg Leu Gly His Ala Glu Gln Lys 
        355                 360                 365             


Asp Glu Met Val Pro Arg Leu Val Lys Leu Phe Asp Phe Pro Gly Arg 
    370                 375                 380                 


Gly Ala Ser Gln Ile Tyr Ala Gly Tyr Thr Cys Ser Phe Ala Val Ser 
385                 390                 395                 400 


Glu Val Gly Gly Leu Phe Phe Trp Gly Ala Thr Asn Thr Ser Arg Glu 
                405                 410                 415     


Ser Thr Met Tyr Pro Lys Ala Val Gln Asp Leu Cys Gly Trp Arg Ile 
            420                 425                 430         


Arg Ser Leu Ala Cys Gly Lys Ser Ser Ile Ile Val Ala Ala Asp Glu 
        435                 440                 445             


Ser Thr Ile Ser Trp Gly Pro Ser Pro Thr Phe Gly Glu Leu Gly Tyr 
    450                 455                 460                 


Gly Asp His Lys Pro Lys Ser Ser Thr Ala Ala Gln Glu Val Lys Thr 
465                 470                 475                 480 


Leu Asp Gly Ile Phe Ser Glu Gln Val Ala Met Gly Tyr Ser His Ser 
                485                 490                 495     


Leu Val Ile Ala Arg Asp Glu Ser Glu Thr Glu Lys Glu Lys Ile Lys 
            500                 505                 510         


Lys Leu Pro Glu Tyr Asn Pro Arg Thr Leu 
        515                 520         


<210> 6476
<211> 183
<212> PRT
<213> Homo sapiens

<400> 6476
Met Thr Asp Gln Thr Tyr Cys Asp Arg Leu Val Gln Asp Thr Pro Phe 
1               5                   10                  15      


Leu Thr Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile 
            20                  25                  30          


Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Thr Asn Lys Glu Ala 
        35                  40                  45              


Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp 
    50                  55                  60                  


Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe 
65                  70                  75                  80  


Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro 
                85                  90                  95      


Ser Arg His Ala Leu Gln Asn Ser Asp Cys Thr Glu Leu Asp Ser Gly 
            100                 105                 110         


Ser Gln Ser Gly Glu Leu Ser Asn Arg Gly Pro Met Ser Phe Leu Ala 
        115                 120                 125             


Gly Leu Gly Leu Ala Val Gly Leu Ala Leu Leu Leu Tyr Cys Tyr Pro 
    130                 135                 140                 


Pro Asp Pro Lys Gly Leu Pro Gly Thr Arg Arg Val Leu Gly Phe Ser 
145                 150                 155                 160 


Pro Val Ile Ile Asp Arg His Val Ser Arg Tyr Leu Leu Ala Phe Leu 
                165                 170                 175     


Ala Asp Asp Leu Gly Gly Leu 
            180             


<210> 6477
<211> 163
<212> PRT
<213> Homo sapiens

<400> 6477
Met Leu Asp Leu Leu Asp Ile Glu Gly Leu Tyr Pro Leu Tyr Asn Arg 
1               5                   10                  15      


Val Glu Arg Tyr Leu Glu Glu Phe Pro Glu Glu Arg Lys Thr Leu Gln 
            20                  25                  30          


Ile Asp Gly Pro Tyr Asp Glu Ala Phe Tyr Gln Lys Leu Leu Asp Leu 
        35                  40                  45              


Ser Thr Glu Asp Asp Gly Thr Val Ala Phe Ala Leu Thr Lys Val Gln 
    50                  55                  60                  


Gln Tyr Arg Val Ala Met Thr Ala Lys Asp Cys Ser Ile Met Ile Ala 
65                  70                  75                  80  


Leu Ser Pro Cys Leu Gln Asp Ala Ser Ser Asp Gln Arg Pro Val Val 
                85                  90                  95      


Pro Ser Ser Arg Ser Arg Phe Ala Phe Ser Val Ser Val Leu Asp Leu 
            100                 105                 110         


Asp Leu Lys Pro Tyr Glu Ser Ile Pro His Gln Tyr Lys Leu Asp Gly 
        115                 120                 125             


Lys Ile Val Asn Tyr Tyr Ser Lys Thr Val Arg Ala Lys Asp Asn Ala 
    130                 135                 140                 


Val Met Ser Thr Arg Phe Lys Glu Ser Glu Asp Cys Thr Leu Val Leu 
145                 150                 155                 160 


His Lys Val 
            


<210> 6478
<211> 258
<212> PRT
<213> Homo sapiens

<400> 6478
Met Ala Arg Pro Pro Val Pro Gly Ser Val Val Val Pro Asn Trp His 
1               5                   10                  15      


Glu Ser Ala Glu Gly Lys Glu Tyr Leu Ala Cys Ile Leu Arg Lys Asn 
            20                  25                  30          


Arg Arg Arg Val Phe Gly Leu Leu Glu Arg Pro Val Leu Leu Pro Pro 
        35                  40                  45              


Val Ser Ile Asp Thr Ala Ser Tyr Lys Ile Phe Val Ser Gly Lys Ser 
    50                  55                  60                  


Gly Val Gly Lys Thr Ala Leu Val Ala Lys Leu Ala Gly Leu Glu Val 
65                  70                  75                  80  


Pro Val Val His His Glu Thr Thr Gly Ile Gln Thr Thr Val Val Phe 
                85                  90                  95      


Trp Pro Ala Lys Leu Gln Ala Ser Ser Arg Val Val Met Phe Arg Phe 
            100                 105                 110         


Glu Phe Trp Asp Cys Gly Glu Ser Ala Leu Lys Lys Phe Asp His Met 
        115                 120                 125             


Leu Leu Ala Cys Met Glu Asn Thr Asp Ala Phe Leu Phe Leu Phe Ser 
    130                 135                 140                 


Phe Thr Asp Arg Ala Ser Phe Glu Asp Leu Pro Gly Gln Leu Ala Arg 
145                 150                 155                 160 


Ile Ala Gly Glu Ala Pro Gly Val Val Arg Met Val Ile Gly Ser Lys 
                165                 170                 175     


Phe Asp Gln Tyr Met His Thr Asp Val Pro Glu Arg Asp Leu Thr Ala 
            180                 185                 190         


Phe Arg Gln Ala Trp Glu Leu Pro Leu Leu Arg Val Lys Ser Val Pro 
        195                 200                 205             


Gly Arg Arg Leu Ala Asp Gly Arg Thr Leu Asp Gly Arg Ala Gly Leu 
    210                 215                 220                 


Ala Asp Val Ala His Ile Leu Asn Gly Leu Ala Glu Gln Leu Trp His 
225                 230                 235                 240 


Gln Asp Gln Val Ala Ala Gly Leu Leu Pro Asn Pro Pro Glu Ser Ala 
                245                 250                 255     


Pro Glu 
        


<210> 6479
<211> 110
<212> PRT
<213> Homo sapiens

<400> 6479
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Gln Phe Ile Arg Ser 
1               5                   10                  15      


Val Gly Glu Gly Thr Ile Asn Gly Leu Leu Gly Glu Leu Leu Glu Thr 
            20                  25                  30          


Arg Val Leu Ser Gln Glu Glu Ile Glu Ile Val Lys Cys Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Ala Arg Ala Leu Leu Asp Ser Val Ile Arg Lys 
    50                  55                  60                  


Gly Ala Pro Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser His Leu Ala Gly Thr Leu Gly Leu Ser Ala Gly Pro Thr Ser Gly 
                85                  90                  95      


Asn His Leu Thr Thr Gln Asp Ser Gln Ile Val Leu Pro Ser 
            100                 105                 110 


<210> 6480
<211> 307
<212> PRT
<213> Homo sapiens

<400> 6480
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Arg Ser Glu 
    290                 295                 300                 


Phe Phe Asn 
305         


<210> 6481
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 6481
Met Glu Pro Gly Glu Val Lys Asp Arg Ile Leu Glu Asn Ile Ser Leu 
1               5                   10                  15      


Ser Val Lys Lys Leu Gln Ser Tyr Phe Ala Ala Cys Glu Asp Glu Ile 
            20                  25                  30          


Pro Ala Ile Arg Asn His Asp Lys Val Leu Gln Arg Leu Cys Glu His 
        35                  40                  45              


Leu Asp His Ala Leu Leu Tyr Gly Leu Gln Asp Leu Ser Ser Gly Tyr 
    50                  55                  60                  


Trp Val Leu Val Val His Phe Thr Arg Arg Glu Ala Ile Lys Gln Ile 
65                  70                  75                  80  


Glu Val Leu Gln His Val Ala Thr Asn Leu Gly Arg Ser Arg Ala Trp 
                85                  90                  95      


Leu Tyr Leu Ala Leu Asn Glu Asn Ser Leu Glu Ser Tyr Leu Arg Leu 
            100                 105                 110         


Phe Gln Glu Asn Leu Gly Leu Leu His Lys Tyr Tyr Val Lys Asn Ala 
        115                 120                 125             


Leu Val Cys Ser His Asp His Leu Thr Leu Phe Leu Thr Leu Val Ser 
    130                 135                 140                 


Gly Leu Glu Phe Ile Arg Phe Glu Leu Asp Leu Asp Ala Pro Tyr Leu 
145                 150                 155                 160 


Asp Leu Ala Pro Tyr Met Pro Asp Tyr Tyr Lys Pro Gln Tyr Leu Leu 
                165                 170                 175     


Asp Phe Glu Asp Arg Leu Pro Ser Ser Val His Gly Ser Asp Ser Leu 
            180                 185                 190         


Ser Leu Asn Ser Phe Asn Ser Val Thr Ser Thr Asn Leu Glu Trp Asp 
        195                 200                 205             


Asp Ser Ala Ile Ala Pro Ser Ser Glu Asp Tyr Asp Phe Gly Asp Val 
    210                 215                 220                 


Phe Pro Ala Val Pro Ser Val Pro Ser Thr Asp Trp Glu Asp Gly Asp 
225                 230                 235                 240 


Leu Thr Asp Thr Val Ser Gly Pro Arg Ser Thr Ala Ser Asp Leu Thr 
                245                 250                 255     


Ser Ser Lys Ala Ser Thr Arg Ser Pro Thr Gln Arg Gln Asn Pro Phe 
            260                 265                 270         


Asn Glu Glu Pro Ala Glu Thr Val Ser Ser Ser Asp Thr Thr Pro Val 
        275                 280                 285             


His Thr Thr Ser Gln Glu Lys Glu Glu Ala Gln Ala Leu Asp Pro Pro 
    290                 295                 300                 


Asp Ala Cys Thr Glu Leu Glu Val Ile Arg Val Thr Lys Lys Lys Lys 
305                 310                 315                 320 


Ile Gly Lys Lys Lys Lys Ser Arg Ser Asp Glu Glu Ala Ser Pro Leu 
                325                 330                 335     


His Pro Ala Cys Ser Gln Lys Lys Cys Ala Lys Gln Gly Asp Gly Asp 
            340                 345                 350         


Ser Arg Asn Gly Ser Pro Ser Leu Gly Arg Asp Ser Pro Asp Thr Met 
        355                 360                 365             


Leu Ala Ser Pro Gln Glu Glu Gly Glu Gly Pro Ser Ser Thr Thr Glu 
    370                 375                 380                 


Ser Ser Glu Arg Ser Glu Pro Gly Leu Leu Ile Pro Glu Met Lys Asp 
385                 390                 395                 400 


Thr Ser Met Glu Arg Leu Gly Gln Pro Leu Ser Lys Val Ile Asp Gln 
                405                 410                 415     


Leu Asn Gly Gln Leu Asp Pro Ser Thr Trp Cys Ser Arg Ala Glu Pro 
            420                 425                 430         


Pro Asp Gln Ser Phe Arg Thr Gly Ser Pro Gly Asp Ala Pro Glu Arg 
        435                 440                 445             


Pro Pro Leu Cys Asp Phe Ser Glu Gly Leu Ser Ala Pro Met Asp Phe 
    450                 455                 460                 


Tyr Arg Phe Thr Val Glu Ser Pro Ser Thr Val Thr Ser Gly Gly Gly 
465                 470                 475                 480 


His His Asp Pro Ala Gly Leu Gly Gln Pro Leu His Val Pro Ser Ser 
                485                 490                 495     


Pro Glu Ala Ala Gly Gln Glu Glu Glu Gly Gly Gly Gly Glu Gly Gln 
            500                 505                 510         


Thr Pro Arg Pro Leu Glu Asp Thr Thr Arg Glu Ala Gln Glu Leu Glu 
        515                 520                 525             


Ala Gln Leu Ser Leu Val Arg Glu Gly Pro Val Ser Glu Pro Glu Pro 
    530                 535                 540                 


Gly Thr Gln Glu Val Leu Cys Gln Leu Lys Arg Asp Gln Pro Ser Pro 
545                 550                 555                 560 


Cys Leu Ser Ser Ala Glu Asp Ser Gly Val Asp Glu Gly Gln Gly Ser 
                565                 570                 575     


Pro Ser Glu Met Val His Ser Ser Glu Phe Arg Val Asp Asn Asn His 
            580                 585                 590         


Leu Leu Leu Leu Met Ile His Val Phe Arg Glu Asn Glu Glu Gln Leu 
        595                 600                 605             


Phe Lys Met Ile Arg Met Ser Thr Gly His Met Glu Gly Asn Leu Gln 
    610                 615                 620                 


Leu Leu Tyr Val Leu Leu Thr Asp Cys Tyr Val Tyr Leu Leu Arg Lys 
625                 630                 635                 640 


Gly Ala Thr Glu Lys Pro Tyr Leu Val Glu Glu Ala Val Ser Tyr Asn 
                645                 650                 655     


Glu Leu Asp Tyr Val Ser Val Gly Leu Asp Gln Gln Thr Val Lys Leu 
            660                 665                 670         


Val Cys Thr Asn Arg Arg Lys Gln Phe Leu Leu Asp Thr Ala Asp Val 
        675                 680                 685             


Ala Leu Ala Glu Phe Phe Leu Ala Ser Leu Lys Ser Ala Met Ile Lys 
    690                 695                 700                 


Gly Cys Arg Glu Pro Pro Tyr Pro Ser Ile Leu Thr Asp Ala Thr Met 
705                 710                 715                 720 


Glu Lys Leu Ala Leu Ala Lys Phe Val Ala Gln Glu Ser Lys Cys Glu 
                725                 730                 735     


Ala Ser Ala Val Thr Val Arg Phe Tyr Gly Leu Val His Trp Glu Asp 
            740                 745                 750         


Pro Thr Asp Glu Ser Leu Gly Pro Thr Pro Cys His Cys Ser Pro Pro 
        755                 760                 765             


Glu Gly Thr Ile Thr Lys Glu Gly Met Leu His Tyr Lys Ala Gly Thr 
    770                 775                 780                 


Ser Tyr Leu Gly Lys Glu His Trp Lys Thr Cys Phe Val Val Leu Ser 
785                 790                 795                 800 


Asn Gly Ile Leu Tyr Gln Tyr Pro Asp Arg Thr Asp Val Ile Pro Leu 
                805                 810                 815     


Leu Ser Val Asn Met Gly Gly Glu Gln Cys Gly Gly Cys Arg Arg Ala 
            820                 825                 830         


Asn Thr Thr Asp Arg Pro His Ala Phe Gln Val Ile Leu Ser Asp Arg 
        835                 840                 845             


Pro Cys Leu Glu Leu Ser Ala Glu Ser Glu Ala Glu Met Ala Glu Trp 
    850                 855                 860                 


Met Gln His Leu Cys Gln Ala Val Ser Lys Gly Val Ile Pro Gln Gly 
865                 870                 875                 880 


Val Ala Pro Ser Pro Cys Ile Pro Cys Cys Leu Val Leu Thr Asp Asp 
                885                 890                 895     


Arg Leu Phe Thr Cys His Glu Asp Cys Gln Thr Ser Phe Phe Arg Ser 
            900                 905                 910         


Leu Gly Thr Ala Lys Leu Gly Asp Ile Ser Ala Val Ser Thr Glu Pro 
        915                 920                 925             


Gly Lys Glu Tyr Cys Val Leu Glu Phe Ser Gln Asp Ser Gln Gln Leu 
    930                 935                 940                 


Leu Pro Pro Trp Val Ile Tyr Leu Ser Cys Thr Ser Glu Leu Asp Arg 
945                 950                 955                 960 


Leu Leu Ser Ala Leu Asn Ser Gly Trp Lys Thr Ile Tyr Gln Val Asp 
                965                 970                 975     


Leu Pro His Thr Ala Ile Gln Glu Ala Ser Asn Lys Lys Lys Phe Glu 
            980                 985                 990         


Asp Ala Leu Ser Leu Ile His Ser  Ala Trp Gln Arg Ser  Asp Ser Leu 
        995                 1000                 1005             


Cys Arg  Gly Arg Ala Ser Arg  Asp Pro Trp Cys 
    1010                 1015                 


<210> 6482
<211> 105
<212> PRT
<213> Homo sapiens

<400> 6482
Met Lys Pro Phe Glu Asp Ala Leu Lys Asn Gln Pro Leu Gly Pro Val 
1               5                   10                  15      


Leu Ser Lys Ala Ala Ser Val Glu Cys Ile Ser Pro Val Ser Pro Arg 
            20                  25                  30          


Ala Pro Asp Ala Lys Met Leu Glu Glu Leu Gln Ala Glu Thr Trp Tyr 
        35                  40                  45              


Gln Gly Glu Met Ser Arg Lys Glu Ala Glu Gly Leu Leu Glu Lys Asp 
    50                  55                  60                  


Gly Asp Phe Leu Val Arg Lys Ser Thr Thr Asn Pro Gly Ser Phe Val 
65                  70                  75                  80  


Leu Thr Gly Met His Asn Gly Gln Ala Lys His Leu Leu Leu Val Asp 
                85                  90                  95      


Pro Glu Gly Thr Arg Ser Asn Ser Tyr 
            100                 105 


<210> 6483
<211> 105
<212> PRT
<213> Homo sapiens

<400> 6483
Met Lys Pro Phe Glu Asp Ala Leu Lys Asn Gln Pro Leu Gly Pro Val 
1               5                   10                  15      


Leu Ser Lys Ala Ala Ser Val Glu Cys Ile Ser Pro Val Ser Pro Arg 
            20                  25                  30          


Ala Pro Asp Ala Lys Met Leu Glu Glu Leu Gln Ala Glu Thr Trp Tyr 
        35                  40                  45              


Gln Gly Glu Met Ser Arg Lys Glu Ala Glu Gly Leu Leu Glu Lys Asp 
    50                  55                  60                  


Gly Asp Phe Leu Val Arg Lys Ser Thr Thr Asn Pro Gly Ser Phe Val 
65                  70                  75                  80  


Leu Thr Gly Met His Asn Gly Gln Ala Lys His Leu Leu Leu Val Asp 
                85                  90                  95      


Pro Glu Gly Thr Arg Ser Asn Ser Tyr 
            100                 105 


<210> 6484
<211> 594
<212> PRT
<213> Homo sapiens

<400> 6484
Met Leu Pro Arg Thr Lys Tyr Asn Arg Phe Arg Asn Asp Ser Val Thr 
1               5                   10                  15      


Ser Val Asp Asp Leu Leu His Ser Leu Ser Val Ser Gly Gly Gly Gly 
            20                  25                  30          


Lys Val Ser Ala Ala Arg Ala Thr Pro Ala Ala Ala Pro Tyr Leu Val 
        35                  40                  45              


Ser Gly Glu Ala Leu Arg Lys Ala Pro Asp Asp Gly Pro Gly Ser Leu 
    50                  55                  60                  


Gly His Leu Leu His Lys Val Ser His Leu Lys Leu Ser Ser Ser Gly 
65                  70                  75                  80  


Leu Arg Gly Leu Ser Ser Ala Ala Arg Glu Arg Ala Gly Ala Arg Leu 
                85                  90                  95      


Ser Gly Ser Cys Ser Ala Pro Ser Leu Ala Ala Pro Asp Gly Ser Ala 
            100                 105                 110         


Pro Ser Ala Pro Arg Ala Pro Ala Met Ser Ala Ala Arg Lys Gly Arg 
        115                 120                 125             


Pro Gly Asp Glu Pro Leu Pro Arg Pro Pro Arg Gly Ala Pro His Ala 
    130                 135                 140                 


Ser Asp Gln Val Leu Gly Pro Gly Val Thr Tyr Val Val Lys Tyr Leu 
145                 150                 155                 160 


Gly Cys Ile Glu Val Leu Arg Ser Met Arg Ser Leu Asp Phe Ser Thr 
                165                 170                 175     


Arg Thr Gln Ile Thr Arg Glu Ala Ile Ser Arg Val Cys Glu Ala Val 
            180                 185                 190         


Pro Gly Ala Lys Gly Ala Phe Lys Lys Arg Lys Pro Pro Ser Lys Met 
        195                 200                 205             


Leu Ser Ser Ile Leu Gly Lys Ser Asn Leu Gln Phe Ala Gly Met Ser 
    210                 215                 220                 


Ile Ser Leu Thr Ile Ser Thr Ala Ser Leu Asn Leu Arg Thr Pro Asp 
225                 230                 235                 240 


Ser Lys Gln Ile Ile Ala Asn His His Met Arg Ser Ile Ser Phe Ala 
                245                 250                 255     


Ser Gly Gly Asp Pro Asp Thr Thr Asp Tyr Val Ala Tyr Val Ala Lys 
            260                 265                 270         


Asp Pro Val Asn Arg Arg Ala Cys His Ile Leu Glu Cys Cys Asp Gly 
        275                 280                 285             


Leu Ala Gln Asp Val Ile Gly Ser Ile Gly Gln Ala Phe Glu Leu Arg 
    290                 295                 300                 


Phe Lys Gln Tyr Leu Gln Cys Pro Thr Lys Ile Pro Ala Leu His Asp 
305                 310                 315                 320 


Arg Met Gln Ser Leu Asp Glu Pro Trp Thr Glu Glu Glu Gly Asp Gly 
                325                 330                 335     


Ser Asp His Pro Tyr Tyr Asn Ser Ile Pro Ser Lys Met Pro Pro Pro 
            340                 345                 350         


Gly Gly Phe Leu Asp Thr Arg Leu Lys Pro Arg Pro His Ala Pro Asp 
        355                 360                 365             


Thr Ala Gln Phe Ala Gly Lys Glu Gln Thr Tyr Tyr Gln Gly Arg His 
    370                 375                 380                 


Leu Gly Asp Thr Phe Gly Glu Asp Trp Gln Gln Thr Pro Leu Arg Gln 
385                 390                 395                 400 


Gly Ser Ser Asp Ile Tyr Ser Thr Pro Glu Gly Lys Leu His Val Ala 
                405                 410                 415     


Pro Thr Gly Glu Ala Pro Thr Tyr Val Asn Thr Gln Gln Ile Pro Pro 
            420                 425                 430         


Gln Ala Trp Pro Ala Ala Val Ser Ser Ala Glu Ser Ser Pro Arg Lys 
        435                 440                 445             


Asp Leu Phe Asp Met Lys Pro Phe Glu Asp Ala Leu Lys Asn Gln Pro 
    450                 455                 460                 


Leu Gly Pro Val Leu Ser Lys Ala Ala Ser Val Glu Cys Ile Ser Pro 
465                 470                 475                 480 


Val Ser Pro Arg Ala Pro Asp Ala Lys Met Leu Glu Glu Leu Gln Ala 
                485                 490                 495     


Glu Thr Trp Tyr Gln Gly Glu Met Ser Arg Lys Glu Ala Glu Gly Leu 
            500                 505                 510         


Leu Glu Lys Asp Gly Asp Phe Leu Val Arg Lys Ser Thr Thr Asn Pro 
        515                 520                 525             


Gly Ser Phe Val Leu Thr Gly Met His Asn Gly Gln Ala Lys His Leu 
    530                 535                 540                 


Leu Leu Val Asp Pro Glu Gly Thr Ile Arg Thr Lys Asp Arg Val Phe 
545                 550                 555                 560 


Asp Ser Ile Ser His Leu Ile Asn His His Leu Glu Ser Ser Leu Pro 
                565                 570                 575     


Ile Val Ser Ala Gly Ser Glu Leu Cys Leu Gln Gln Pro Val Glu Arg 
            580                 585                 590         


Lys Gln 
        


<210> 6485
<211> 230
<212> PRT
<213> Homo sapiens

<400> 6485
Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp Val Glu 
1               5                   10                  15      


Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Cys Asp Val Ser Trp 
            20                  25                  30          


Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val Arg Ile 
        35                  40                  45              


Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr Met Val 
    50                  55                  60                  


Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala Gly Lys 
65                  70                  75                  80  


Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu Met Pro 
                85                  90                  95      


Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro Gly Ile 
            100                 105                 110         


Thr Trp Ile Met Lys Pro Asp Thr Arg Ser Ser Asp Asp Gln Lys Asp 
        115                 120                 125             


Asp Ile Pro Val Glu Asn Tyr Val Ala Gln Arg Tyr Ile Glu Asn Pro 
    130                 135                 140                 


Tyr Leu Ile Gly Gly Arg Lys Phe Asp Leu Arg Val Tyr Val Leu Val 
145                 150                 155                 160 


Met Ser Tyr Ile Pro Leu Arg Ala Trp Leu Tyr Arg Asp Gly Phe Ala 
                165                 170                 175     


Arg Phe Ser Asn Thr Arg Phe Thr Leu Asn Ser Ile Asp Asp Gln Tyr 
            180                 185                 190         


Val His Leu Thr Asn Val Ala Val Gln Lys Thr Ser Pro Asp Tyr His 
        195                 200                 205             


Pro Lys Lys Val Ala Pro Gly Gly Gln Cys Val Pro Ile Thr Asp Ser 
    210                 215                 220                 


Gln Gln Pro Gly Arg Leu 
225                 230 


<210> 6486
<211> 355
<212> PRT
<213> Homo sapiens

<400> 6486
Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp Val Glu 
1               5                   10                  15      


Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Cys Asp Val Ser Trp 
            20                  25                  30          


Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val Arg Ile 
        35                  40                  45              


Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr Met Val 
    50                  55                  60                  


Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala Gly Lys 
65                  70                  75                  80  


Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu Met Pro 
                85                  90                  95      


Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro Gly Ile 
            100                 105                 110         


Thr Trp Ile Met Lys Pro Asp Thr Arg Ser Ser Asp Asp Gln Lys Asp 
        115                 120                 125             


Asp Ile Pro Val Glu Asn Tyr Val Ala Gln Arg Tyr Ile Glu Asn Pro 
    130                 135                 140                 


Tyr Leu Ile Gly Gly Arg Lys Phe Asp Leu Arg Val Tyr Val Leu Val 
145                 150                 155                 160 


Met Ser Tyr Ile Pro Leu Arg Ala Trp Leu Tyr Arg Asp Gly Phe Ala 
                165                 170                 175     


Arg Phe Ser Asn Thr Arg Phe Thr Leu Asn Ser Ile Asp Asp Gln Tyr 
            180                 185                 190         


Val His Leu Thr Asn Val Ala Val Gln Lys Thr Ser Pro Asp Tyr His 
        195                 200                 205             


Pro Lys Lys Gly Cys Lys Trp Thr Leu Gln Arg Phe Arg Gln Tyr Leu 
    210                 215                 220                 


Ala Ser Lys His Gly Pro Glu Ala Val Glu Thr Leu Phe Arg Asp Ile 
225                 230                 235                 240 


Asp Asn Ile Phe Val Lys Ser Leu Gln Ser Val Gln Lys Val Ile Ile 
                245                 250                 255     


Ser Asp Lys His Cys Phe Glu Leu Tyr Gly Tyr Asp Ile Leu Ile Asp 
            260                 265                 270         


Gln Asp Leu Lys Pro Trp Leu Leu Glu Val Asn Ala Ser Pro Ser Leu 
        275                 280                 285             


Thr Ala Ser Ser Gln Glu Asp Tyr Glu Leu Lys Thr Cys Leu Leu Glu 
    290                 295                 300                 


Asp Thr Leu His Val Val Asp Met Glu Ala Arg Leu Arg Gln Arg Ser 
305                 310                 315                 320 


Glu Glu Thr Thr Glu Ala Ala Leu Leu Leu Pro Ser Ser Ser Glu Glu 
                325                 330                 335     


Ser Phe Gln Leu Ile Pro Ser Cys Gln Glu Glu Ile Ser Leu Ser Arg 
            340                 345                 350         


Pro Cys Val 
        355 


<210> 6487
<211> 279
<212> PRT
<213> Homo sapiens

<400> 6487
Met Ser Arg Pro Lys Asn Gln Asn Tyr Lys Gly His Gly Leu Ser Lys 
1               5                   10                  15      


Gly Lys Glu Arg Glu Gln Arg Ala Ser Ile Arg Phe Lys Thr Thr Leu 
            20                  25                  30          


Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp Val Glu 
        35                  40                  45              


Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Cys Asp Val Ser Trp 
    50                  55                  60                  


Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val Arg Ile 
65                  70                  75                  80  


Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr Met Val 
                85                  90                  95      


Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala Gly Lys 
            100                 105                 110         


Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu Met Pro 
        115                 120                 125             


Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro Gly Ile 
    130                 135                 140                 


Thr Trp Ile Met Lys Pro Val Ala Arg Ser Gln Gly Lys Gly Ile Phe 
145                 150                 155                 160 


Leu Phe Arg Arg Leu Lys Asp Ile Val Asp Trp Arg Lys Asp Thr Arg 
                165                 170                 175     


Ser Ser Asp Asp Gln Lys Asp Asp Ile Pro Val Glu Asn Tyr Val Ala 
            180                 185                 190         


Gln Arg Tyr Ile Glu Asn Pro Tyr Leu Ile Gly Gly Arg Lys Phe Asp 
        195                 200                 205             


Leu Arg Val Tyr Val Leu Val Met Ser Met Phe Thr Ser Pro Thr Trp 
    210                 215                 220                 


Leu Cys Lys Lys His Leu Pro Thr Thr Thr Gln Arg Arg Ala Ala Ser 
225                 230                 235                 240 


Gly Arg Cys Ser Ala Ser Gly Ser Thr Trp Arg Pro Asn Thr Gly Pro 
                245                 250                 255     


Arg Gln Trp Arg His Ser Ser Gly Thr Ser Thr Thr Ser Leu Ser Lys 
            260                 265                 270         


Ala Cys Arg Val Cys Arg Arg 
        275                 


<210> 6488
<211> 371
<212> PRT
<213> Homo sapiens

<400> 6488
Met Ser Arg Pro Lys Asn Gln Asn Tyr Lys Gly His Gly Leu Ser Lys 
1               5                   10                  15      


Gly Lys Glu Arg Glu Gln Arg Ala Ser Ile Arg Phe Lys Thr Thr Leu 
            20                  25                  30          


Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp Val Glu 
        35                  40                  45              


Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Cys Asp Val Ser Trp 
    50                  55                  60                  


Leu Arg Glu Asn Leu Glu Arg Glu Ala Gly Lys Leu Glu Ala Ala Lys 
65                  70                  75                  80  


Cys Asp Phe Phe Pro Lys Thr Phe Glu Met Pro Cys Glu Tyr His Leu 
                85                  90                  95      


Phe Val Glu Glu Phe Arg Lys Asn Pro Gly Ile Thr Trp Ile Met Lys 
            100                 105                 110         


Pro Val Ala Arg Ser Gln Gly Lys Gly Ile Phe Leu Phe Arg Arg Leu 
        115                 120                 125             


Lys Asp Ile Val Asp Trp Arg Lys Asp Thr Arg Ser Ser Asp Asp Gln 
    130                 135                 140                 


Lys Asp Asp Ile Pro Val Glu Asn Tyr Val Ala Gln Arg Tyr Ile Glu 
145                 150                 155                 160 


Asn Pro Tyr Leu Ile Gly Gly Arg Lys Phe Asp Leu Arg Val Tyr Val 
                165                 170                 175     


Leu Val Met Ser Tyr Ile Pro Leu Arg Ala Trp Leu Tyr Arg Asp Gly 
            180                 185                 190         


Phe Ala Arg Phe Ser Asn Thr Arg Phe Thr Leu Asn Ser Ile Asp Asp 
        195                 200                 205             


Gln Tyr Val His Leu Thr Asn Val Ala Val Gln Lys Thr Ser Pro Asp 
    210                 215                 220                 


Tyr His Pro Lys Lys Leu His Pro Thr Val Gly Pro Leu Cys Ile His 
225                 230                 235                 240 


Ser Pro Glu Asn Gly Ser Leu Ser Val Thr Pro Trp Pro Trp Asp Ala 
                245                 250                 255     


His Met Gly Cys Lys Trp Thr Leu Gln Arg Phe Arg Gln Tyr Leu Ala 
            260                 265                 270         


Ser Lys His Gly Pro Glu Ala Val Glu Thr Leu Phe Arg Asp Ile Asp 
        275                 280                 285             


Asn Ile Phe Val Lys Ser Leu Gln Ser Val Gln Lys Val Ile Ile Ser 
    290                 295                 300                 


Asp Lys His Cys Phe Glu Leu Tyr Gly Tyr Asp Ile Leu Ile Asp Gln 
305                 310                 315                 320 


Asp Leu Lys Pro Trp Leu Leu Glu Val Asn Ala Ser Pro Ser Leu Thr 
                325                 330                 335     


Ala Ser Ser Gln Glu Asp Tyr Glu Leu Lys Thr Cys Leu Leu Glu Asp 
            340                 345                 350         


Thr Leu His Val Val Asp Met Glu Ala Ser Phe Ser Pro Ile Ile Pro 
        355                 360                 365             


Ala Glu Val 
    370     


<210> 6489
<211> 439
<212> PRT
<213> Homo sapiens

<400> 6489
Met Val Pro Ser Arg Glu Ala Leu Leu Gly Pro Gly Thr Thr Ala Ile 
1               5                   10                  15      


Arg Cys Pro Lys Lys Leu Gln Asn Gln Asn Tyr Lys Gly His Gly Leu 
            20                  25                  30          


Ser Lys Gly Lys Glu Arg Glu Gln Arg Ala Ser Ile Arg Phe Lys Thr 
        35                  40                  45              


Thr Leu Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp 
    50                  55                  60                  


Val Glu Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Cys Asp Val 
65                  70                  75                  80  


Ser Trp Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val 
                85                  90                  95      


Arg Ile Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr 
            100                 105                 110         


Met Val Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala 
        115                 120                 125             


Gly Lys Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu 
    130                 135                 140                 


Met Pro Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Ile Thr Trp Ile Met Lys Pro Val Ala Arg Ser Gln Gly Lys Gly 
                165                 170                 175     


Ile Phe Leu Phe Arg Arg Leu Lys Asp Ile Val Asp Trp Arg Lys Asp 
            180                 185                 190         


Thr Arg Ser Ser Asp Asp Gln Lys Asp Asp Ile Pro Val Glu Asn Tyr 
        195                 200                 205             


Val Ala Gln Arg Tyr Ile Glu Asn Pro Tyr Leu Ile Gly Gly Arg Lys 
    210                 215                 220                 


Phe Asp Leu Arg Val Tyr Val Leu Val Met Ser Val Phe Ala Glu Cys 
225                 230                 235                 240 


Leu Leu Trp Ser Gly His Arg Arg Gln Asp Val His Leu Thr Asn Val 
                245                 250                 255     


Ala Val Gln Lys Thr Ser Pro Asp Tyr His Pro Lys Lys Gly Cys Lys 
            260                 265                 270         


Trp Thr Leu Gln Arg Phe Arg Gln Tyr Leu Ala Ser Lys His Gly Pro 
        275                 280                 285             


Glu Ala Val Glu Thr Leu Phe Arg Asp Ile Asp Asn Ile Phe Val Lys 
    290                 295                 300                 


Ser Leu Gln Ser Val Gln Lys Val Ile Ile Ser Asp Lys His Cys Phe 
305                 310                 315                 320 


Glu Leu Tyr Gly Tyr Asp Ile Leu Ile Asp Gln Asp Leu Lys Pro Trp 
                325                 330                 335     


Leu Leu Glu Val Asn Ala Ser Pro Ser Leu Thr Ala Ser Ser Gln Glu 
            340                 345                 350         


Asp Tyr Glu Leu Lys Thr Cys Leu Leu Glu Asp Thr Leu His Val Val 
        355                 360                 365             


Asp Met Glu Ala Arg Leu Thr Gly Arg Glu Lys Arg Val Gly Gly Phe 
    370                 375                 380                 


Asp Leu Met Trp Asn Asp Gly Pro Val Ser Arg Glu Glu Gly Ala Pro 
385                 390                 395                 400 


Asp Leu Ser Gly Met Gly Asn Phe Val Thr Asn Thr His Leu Gly Cys 
                405                 410                 415     


Val Asn Asp Arg Lys Lys Gln Leu Arg Gln Leu Phe Cys Ser Leu Gln 
            420                 425                 430         


Val Gln Lys Lys Ala Ser Ser 
        435                 


<210> 6490
<211> 166
<212> PRT
<213> Homo sapiens

<400> 6490
Met Lys Glu Met Leu Ala Lys Asp Leu Glu Glu Ser Gln Gly Gly Lys 
1               5                   10                  15      


Ser Ser Glu Val Leu Ser Ala Thr Glu Leu Arg Val Gln Leu Ala Gln 
            20                  25                  30          


Lys Glu Gln Glu Leu Ala Arg Ala Lys Glu Ala Leu Gln Ala Met Lys 
        35                  40                  45              


Ala Asp Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln 
    50                  55                  60                  


Met Gln Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg 
65                  70                  75                  80  


Asp Phe Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala 
                85                  90                  95      


Val Lys Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp 
            100                 105                 110         


Glu Leu Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu 
        115                 120                 125             


Arg Ser Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala 
    130                 135                 140                 


Glu Leu Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val 
145                 150                 155                 160 


Pro Lys Arg His Ser Leu 
                165     


<210> 6491
<211> 775
<212> PRT
<213> Homo sapiens

<400> 6491
Met Met Glu Asp Asn Lys Gln Leu Ala Leu Arg Ile Asp Gly Ala Val 
1               5                   10                  15      


Gln Ser Ala Ser Gln Glu Val Thr Asn Leu Arg Ala Glu Leu Thr Ala 
            20                  25                  30          


Thr Asn Arg Arg Leu Ala Glu Leu Ser Gly Gly Gly Gly Pro Gly Pro 
        35                  40                  45              


Gly Pro Gly Ala Ala Ala Ser Ala Ser Ala Ala Gly Asp Ser Ala Ala 
    50                  55                  60                  


Thr Asn Met Glu Asn Pro Gln Leu Gly Ala Gln Val Leu Leu Arg Glu 
65                  70                  75                  80  


Glu Val Ser Arg Leu Gln Glu Glu Val His Leu Leu Arg Gln Met Lys 
                85                  90                  95      


Glu Met Leu Ala Lys Asp Leu Glu Glu Ser Gln Gly Gly Lys Ser Ser 
            100                 105                 110         


Glu Val Leu Ser Ala Thr Glu Leu Arg Val Gln Leu Ala Gln Lys Glu 
        115                 120                 125             


Gln Glu Leu Ala Arg Ala Lys Glu Ala Leu Gln Ala Met Lys Ala Asp 
    130                 135                 140                 


Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln Met Gln 
145                 150                 155                 160 


Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg Asp Phe 
                165                 170                 175     


Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala Val Lys 
            180                 185                 190         


Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp Glu Leu 
        195                 200                 205             


Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu Arg Ser 
    210                 215                 220                 


Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val Pro Lys 
                245                 250                 255     


Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu Asn Gly Asn Gln 
            260                 265                 270         


Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala Ala Ile Arg Gln 
        275                 280                 285             


Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His Pro Ala Asp Arg 
    290                 295                 300                 


Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln Pro Ser Val Ile 
305                 310                 315                 320 


Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser Thr Pro Ser Asp 
                325                 330                 335     


Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys Asn Gly Asp Ser 
            340                 345                 350         


Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro Ile Val Gln Ser Leu 
        355                 360                 365             


Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys Glu Lys Met Gly 
    370                 375                 380                 


Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly Lys Gln Arg Lys Ser 
385                 390                 395                 400 


Leu Asp Pro Gly Leu Phe Asp Asp Ser Asp Ser Gln Cys Ser Pro Thr 
                405                 410                 415     


Arg Gln Ser Leu Ser Leu Ser Glu Gly Glu Glu Gln Met Asp Arg Leu 
            420                 425                 430         


Gln Gln Val Glu Leu Val Arg Thr Thr Pro Met Ser His Trp Lys Ala 
        435                 440                 445             


Gly Thr Val Gln Ala Trp Leu Glu Val Val Met Ala Met Pro Met Tyr 
    450                 455                 460                 


Val Lys Ala Cys Thr Glu Asn Val Lys Ser Gly Lys Val Leu Leu Ser 
465                 470                 475                 480 


Leu Ser Asp Glu Asp Leu Gln Leu Gly Leu Gly Val Cys Ser Ser Leu 
                485                 490                 495     


His Arg Arg Lys Leu Arg Leu Ala Ile Glu Asp Tyr Arg Asp Ala Glu 
            500                 505                 510         


Ala Gly Arg Ser Leu Ser Lys Ala Ala Glu Leu Asp His His Trp Val 
        515                 520                 525             


Ala Lys Ala Trp Leu Asn Asp Ile Gly Leu Ser Gln Tyr Ser Gln Ala 
    530                 535                 540                 


Phe Gln Asn His Leu Val Asp Gly Arg Met Leu Asn Ser Leu Met Lys 
545                 550                 555                 560 


Arg Asp Leu Glu Lys His Leu Asn Val Ser Lys Lys Phe His Gln Val 
                565                 570                 575     


Ser Ile Leu Leu Gly Ile Glu Leu Leu Tyr Gln Val Asn Phe Ser Arg 
            580                 585                 590         


Glu Ala Leu Gln Glu Arg Arg Ala Arg Cys Glu Thr Gln Asn Ile Asp 
        595                 600                 605             


Pro Val Val Trp Thr Asn Gln Arg Val Leu Lys Trp Val Arg Asp Ile 
    610                 615                 620                 


Asp Leu Lys Glu Tyr Ala Asp Asn Leu Thr Asn Ser Gly Val His Gly 
625                 630                 635                 640 


Ala Val Leu Val Leu Glu Pro Thr Phe Asn Ala Glu Ala Met Ala Thr 
                645                 650                 655     


Ala Leu Gly Ile Pro Ser Gly Lys His Ile Leu Arg Arg His Leu Ala 
            660                 665                 670         


Glu Glu Met Ser Ala Val Phe His Pro Ala Asn Ser Thr Gly Ile Arg 
        675                 680                 685             


Glu Ala Glu Arg Phe Gly Thr Pro Pro Gly Arg Ala Ser Ser Val Thr 
    690                 695                 700                 


Arg Ala Gly Lys Glu Glu Asn Ser Ser Gly Leu Lys Tyr Lys Ala Gly 
705                 710                 715                 720 


Arg Leu Pro Leu Gly Lys Ile Gly Arg Gly Phe Ser Ser Lys Asp Pro 
                725                 730                 735     


Asp Phe His Asp Asp Tyr Gly Ser Leu Gln Asn Glu Asp Cys Gly Asp 
            740                 745                 750         


Asp Asp Pro Gln Ser Arg Leu Glu Gln Cys Arg Leu Glu Gly Tyr Asn 
        755                 760                 765             


Ser Leu Glu Val Thr Asn Val 
    770                 775 


<210> 6492
<211> 286
<212> PRT
<213> Homo sapiens

<400> 6492
Met Tyr Ser Leu Asp Arg Ile Phe Ala Gly Phe Arg Thr Arg Ser Gln 
1               5                   10                  15      


Met Leu Leu Gly His Ile Glu Glu Gln Asp Lys Val Leu His Cys Gln 
            20                  25                  30          


Phe Ser Asp Asn Ser Asp Asp Glu Glu Ser Glu Gly Gln Glu Lys Ser 
        35                  40                  45              


Gly Thr Arg Cys Arg Ser Arg Ser Trp Ile Gln Lys Pro Asp Ser Val 
    50                  55                  60                  


Cys Ser Leu Val Glu Leu Ser Asp Thr Gln Asp Glu Thr Gln Lys Ser 
65                  70                  75                  80  


Asp Leu Glu Asn Glu Asp Leu Lys Ile Asp Cys Leu Gln Glu Ser Gln 
                85                  90                  95      


Glu Leu Asn Leu Gln Lys Leu Lys Asn Ser Glu Arg Ile Leu Thr Glu 
            100                 105                 110         


Ala Lys Gln Lys Met Arg Glu Leu Thr Ile Asn Ile Lys Met Lys Glu 
        115                 120                 125             


Asp Leu Ile Lys Glu Leu Ile Lys Thr Gly Asn Asp Ala Lys Ser Val 
    130                 135                 140                 


Ser Lys Gln Tyr Ser Leu Lys Val Thr Lys Leu Glu His Asp Ala Glu 
145                 150                 155                 160 


Gln Ala Lys Val Glu Leu Ile Glu Thr Gln Lys Gln Leu Gln Glu Leu 
                165                 170                 175     


Glu Asn Lys Asp Leu Ser Asp Val Ala Met Lys Val Lys Leu Gln Lys 
            180                 185                 190         


Glu Phe Arg Lys Lys Met Asp Ala Ala Lys Leu Arg Val Gln Val Leu 
        195                 200                 205             


Gln Lys Lys Gln Gln Asp Ser Lys Lys Leu Ala Ser Leu Ser Ile Gln 
    210                 215                 220                 


Asn Glu Lys Arg Ala Asn Glu Leu Glu Gln Ser Val Asp His Met Lys 
225                 230                 235                 240 


Tyr Gln Lys Ile Gln Leu Gln Arg Lys Leu Arg Glu Glu Asn Glu Lys 
                245                 250                 255     


Arg Lys Gln Leu Asp Ala Val Ile Lys Arg Asp Gln Gln Lys Ile Lys 
            260                 265                 270         


Val Ile Leu Ser Tyr Ile Pro Ala Lys Tyr Asn Met Lys Cys 
        275                 280                 285     


<210> 6493
<211> 553
<212> PRT
<213> Homo sapiens

<400> 6493
Met Asn Lys Asn Thr Ser Thr Val Val Ser Pro Ser Leu Leu Glu Lys 
1               5                   10                  15      


Asp Pro Ala Phe Gln Met Ile Thr Ile Ala Lys Glu Thr Gly Leu Gly 
            20                  25                  30          


Leu Lys Val Leu Gly Gly Ile Asn Arg Asn Glu Gly Pro Leu Val Tyr 
        35                  40                  45              


Ile Gln Glu Ile Ile Pro Gly Gly Asp Cys Tyr Lys Asp Gly Arg Leu 
    50                  55                  60                  


Lys Pro Gly Asp Gln Leu Val Ser Val Asn Lys Glu Ser Met Ile Gly 
65                  70                  75                  80  


Val Ser Phe Glu Glu Ala Lys Ser Ile Ile Thr Gly Ala Lys Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Trp Glu Ile Ala Phe Ile Arg Gln Lys Ser Asp Asn 
            100                 105                 110         


Ile Gln Pro Glu Asn Leu Ser Cys Thr Ser Leu Ile Glu Ala Ser Gly 
        115                 120                 125             


Glu Tyr Gly Pro Gln Ala Ser Thr Leu Ser Leu Phe Ser Ser Pro Pro 
    130                 135                 140                 


Glu Ile Leu Ile Pro Lys Thr Ser Ser Thr Pro Lys Thr Asn Asn Asp 
145                 150                 155                 160 


Ile Leu Ser Ser Cys Glu Ile Lys Thr Gly Tyr Asn Lys Thr Val Gln 
                165                 170                 175     


Ile Pro Ile Thr Ser Glu Asn Ser Thr Val Gly Leu Ser Asn Thr Asp 
            180                 185                 190         


Val Ala Ser Ala Trp Thr Glu Asn Tyr Gly Leu Gln Glu Lys Ile Ser 
        195                 200                 205             


Leu Asn Pro Ser Val Arg Phe Lys Ala Glu Lys Leu Glu Met Ala Leu 
    210                 215                 220                 


Asn Tyr Leu Gly Ile Gln Pro Thr Lys Glu Gln His Gln Ala Leu Arg 
225                 230                 235                 240 


Gln Gln Val Gln Ala Asp Ser Lys Gly Thr Val Ser Phe Gly Asp Phe 
                245                 250                 255     


Val Gln Val Ala Arg Asn Leu Phe Cys Leu Gln Leu Asp Glu Val Asn 
            260                 265                 270         


Val Gly Ala His Glu Ile Ser Asn Ile Leu Asp Ser Gln Leu Leu Pro 
        275                 280                 285             


Cys Asp Ser Ser Glu Ala Asp Glu Met Glu Arg Leu Lys Cys Glu Arg 
    290                 295                 300                 


Asp Asp Ala Leu Lys Glu Val Asn Thr Leu Lys Glu Lys Leu Leu Glu 
305                 310                 315                 320 


Ser Asp Lys Gln Arg Lys Gln Leu Thr Glu Glu Leu Gln Asn Val Lys 
                325                 330                 335     


Gln Glu Ala Lys Ala Val Val Glu Glu Thr Arg Ala Leu Arg Ser Arg 
            340                 345                 350         


Ile His Leu Ala Glu Ala Ala Gln Arg Gln Ala His Gly Met Glu Met 
        355                 360                 365             


Asp Tyr Glu Glu Val Ile Arg Leu Leu Glu Ala Lys Ile Thr Glu Leu 
    370                 375                 380                 


Lys Ala Gln Leu Ala Asp Tyr Ser Asp Gln Asn Lys Glu Ser Val Gln 
385                 390                 395                 400 


Asp Leu Lys Lys Arg Ile Met Val Leu Asp Cys Gln Leu Arg Lys Ser 
                405                 410                 415     


Glu Met Ala Arg Lys Thr Phe Glu Ala Ser Thr Glu Lys Leu Leu His 
            420                 425                 430         


Phe Val Glu Ala Ile Gln Glu Val Phe Ser Asp Asn Ser Thr Pro Leu 
        435                 440                 445             


Ser Asn Leu Ser Glu Arg Arg Ala Val Leu Ala Ser Gln Thr Ser Leu 
    450                 455                 460                 


Thr Pro Leu Gly Arg Asn Gly Arg Ser Ile Pro Ala Thr Leu Ala Leu 
465                 470                 475                 480 


Glu Ser Lys Glu Leu Val Lys Ser Val Arg Ala Leu Leu Asp Met Asp 
                485                 490                 495     


Cys Leu Pro Tyr Gly Trp Glu Glu Ala Tyr Thr Ala Asp Gly Ile Lys 
            500                 505                 510         


Tyr Phe Ile Asn His Val Thr Gln Thr Thr Ser Trp Ile His Pro Val 
        515                 520                 525             


Met Ser Val Leu Asn Leu Ser Arg Ser Glu Glu Asn Glu Glu Asp Cys 
    530                 535                 540                 


Ser Arg Glu Leu Pro Asn Gln Lys Ser 
545                 550             


<210> 6494
<211> 187
<212> PRT
<213> Homo sapiens

<400> 6494
Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Val Ser Gly Ser Gly 
1               5                   10                  15      


Lys Ser Thr Val Gly Ala Leu Leu Ala Ser Glu Leu Gly Trp Lys Phe 
            20                  25                  30          


Tyr Asp Ala Asp Asp Tyr His Pro Glu Glu Asn Arg Arg Lys Met Gly 
        35                  40                  45              


Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu Cys Asn 
    50                  55                  60                  


Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg Val Val 
65                  70                  75                  80  


Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu Thr Gln 
                85                  90                  95      


Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys Glu Ala 
            100                 105                 110         


Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly Ser Phe 
        115                 120                 125             


Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe Met Pro 
    130                 135                 140                 


Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro Ala Ala 
145                 150                 155                 160 


Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser Glu Ile 
                165                 170                 175     


Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys 
            180                 185         


<210> 6495
<211> 377
<212> PRT
<213> Homo sapiens

<400> 6495
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Ile Met Ser Leu Ala Gly Lys Gly Asn Gln His Leu Val Thr Cys Phe 
            340                 345                 350         


Pro His Pro Val Ser Gly Gly Arg Ala Asn Cys Pro Ile Ser Thr Leu 
        355                 360                 365             


Ile Gln Ser Pro Trp Cys Gly Trp Gly 
    370                 375         


<210> 6496
<211> 740
<212> PRT
<213> Homo sapiens

<400> 6496
Met Glu Ala Asp Gly Asp Gly Glu Glu Leu Ala Arg Leu Arg Ser Val 
1               5                   10                  15      


Phe Ala Ala Cys Asp Ala Asn Arg Ser Gly Arg Leu Glu Arg Glu Glu 
            20                  25                  30          


Phe Arg Ala Leu Cys Thr Glu Leu Arg Val Arg Pro Ala Asp Ala Glu 
        35                  40                  45              


Ala Val Phe Gln Arg Leu Asp Ala Asp Arg Asp Gly Ala Ile Thr Phe 
    50                  55                  60                  


Gln Glu Phe Ala Arg Gly Phe Leu Gly Ser Leu Arg Gly Gly Arg Arg 
65                  70                  75                  80  


Arg Asp Trp Gly Pro Leu Asp Pro Ala Pro Ala Val Ser Glu Ala Gly 
                85                  90                  95      


Pro Glu Thr His Asp Ser Glu Glu Asp Glu Gly Asp Glu Asp Ala Ala 
            100                 105                 110         


Ala Ala Leu Ala Thr Ser Cys Gly Pro Ala Ser Pro Gly Arg Ala Trp 
        115                 120                 125             


Gln Asp Phe Gln Ala Arg Leu Gly Asp Glu Ala Lys Phe Ile Pro Arg 
    130                 135                 140                 


Glu Glu Gln Val Ser Thr Leu Tyr Gln Asn Ile Asn Leu Val Glu Pro 
145                 150                 155                 160 


Arg Leu Ile Gln Pro Tyr Glu His Val Ile Lys Asn Phe Ile Arg Glu 
                165                 170                 175     


Ile Arg Leu Gln Ser Thr Glu Met Glu Asn Leu Ala Ile Ala Val Lys 
            180                 185                 190         


Arg Ala Gln Asp Lys Ala Ala Met Gln Leu Ser Glu Leu Glu Glu Glu 
        195                 200                 205             


Met Asp Gln Arg Ile Gln Ala Ala Glu His Lys Thr Arg Lys Asp Glu 
    210                 215                 220                 


Lys Arg Lys Ala Glu Glu Ala Leu Ser Asp Leu Arg Arg Gln Tyr Glu 
225                 230                 235                 240 


Thr Glu Val Gly Asp Leu Gln Val Thr Ile Lys Lys Leu Arg Lys Leu 
                245                 250                 255     


Glu Glu Gln Ser Lys Arg Val Ser Gln Lys Glu Asp Val Ala Ala Leu 
            260                 265                 270         


Lys Lys Gln Ile Tyr Asp Leu Ser Met Glu Asn Gln Lys Val Lys Lys 
        275                 280                 285             


Asp Leu Leu Glu Ala Gln Thr Asn Ile Ala Phe Leu Gln Ser Glu Leu 
    290                 295                 300                 


Asp Ala Leu Lys Ser Asp Tyr Ala Asp Gln Ser Leu Asn Thr Glu Arg 
305                 310                 315                 320 


Asp Leu Glu Ile Ile Arg Ala Tyr Thr Glu Asp Arg Asn Ser Leu Glu 
                325                 330                 335     


Arg Gln Ile Glu Ile Leu Gln Thr Ala Asn Arg Lys Leu His Asp Ser 
            340                 345                 350         


Asn Asp Gly Leu Arg Ser Ala Leu Glu Asn Ser Tyr Ser Lys Phe Asn 
        355                 360                 365             


Arg Ser Leu His Ile Asn Asn Ile Ser Pro Gly Asn Thr Ile Ser Arg 
    370                 375                 380                 


Ser Ser Pro Lys Phe Ile Gly His Ser Pro Gln Pro Leu Gly Tyr Asp 
385                 390                 395                 400 


Arg Ser Ser Arg Ser Ser Tyr Val Asp Glu Asp Cys Asp Ser Leu Ala 
                405                 410                 415     


Leu Cys Asp Pro Leu Gln Arg Thr Asn Cys Glu Val Asp Ser Leu Pro 
            420                 425                 430         


Glu Ser Cys Phe Asp Ser Gly Leu Ser Thr Leu Arg Asp Pro Asn Glu 
        435                 440                 445             


Tyr Asp Ser Glu Val Glu Tyr Lys His Gln Arg Gly Phe Gln Arg Ser 
    450                 455                 460                 


His Gly Val Gln Glu Ser Phe Gly Gly Asp Ala Ser Asp Thr Asp Val 
465                 470                 475                 480 


Pro Asp Ile Arg Asp Glu Glu Thr Phe Gly Leu Glu Asp Val Ala Ser 
                485                 490                 495     


Val Leu Asp Trp Lys Pro Gln Gly Ser Val Ser Glu Gly Ser Ile Val 
            500                 505                 510         


Ser Ser Ser Arg Lys Pro Ile Ser Ala Leu Ser Pro Gln Thr Asp Leu 
        515                 520                 525             


Val Asp Asp Asn Ala Lys Ser Phe Ser Ser Gln Lys Ala Tyr Lys Ile 
    530                 535                 540                 


Val Leu Ala Gly Asp Ala Ala Val Gly Lys Ser Ser Phe Leu Met Arg 
545                 550                 555                 560 


Leu Cys Lys Asn Glu Phe Arg Glu Asn Ile Ser Ala Thr Leu Gly Val 
                565                 570                 575     


Asp Phe Gln Met Lys Thr Leu Ile Val Asp Gly Glu Arg Thr Val Leu 
            580                 585                 590         


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Ile Ala Lys 
        595                 600                 605             


Ser Tyr Phe Arg Lys Ala Asp Gly Val Leu Leu Leu Tyr Asp Val Thr 
    610                 615                 620                 


Cys Glu Lys Ser Phe Leu Asn Ile Arg Glu Trp Val Asp Met Ile Glu 
625                 630                 635                 640 


Asp Ala Ala His Glu Thr Val Pro Ile Met Leu Val Gly Asn Lys Ala 
                645                 650                 655     


Asp Ile Arg Asp Thr Ala Ala Thr Glu Gly Gln Lys Cys Val Pro Gly 
            660                 665                 670         


His Phe Gly Glu Lys Leu Ala Met Thr Tyr Gly Ala Leu Phe Cys Glu 
        675                 680                 685             


Thr Ser Ala Lys Asp Gly Ser Asn Ile Val Glu Ala Val Leu His Leu 
    690                 695                 700                 


Ala Arg Glu Val Lys Lys Arg Thr Asp Lys Asp Asp Ser Arg Ser Ile 
705                 710                 715                 720 


Thr Asn Leu Thr Gly Thr Asn Ser Lys Lys Ser Pro Gln Met Lys Asn 
                725                 730                 735     


Cys Cys Asn Gly 
            740 


<210> 6497
<211> 1374
<212> PRT
<213> Homo sapiens

<400> 6497
Met Glu Glu Asn Glu Ser Gln Lys Cys Glu Pro Cys Leu Pro Tyr Ser 
1               5                   10                  15      


Ala Asp Arg Arg Gln Met Gln Glu Gln Gly Lys Gly Asn Leu His Val 
            20                  25                  30          


Thr Ser Pro Glu Asp Ala Glu Cys Arg Arg Thr Lys Glu Arg Leu Ser 
        35                  40                  45              


Asn Gly Asn Ser Arg Gly Ser Val Ser Lys Ser Ser Arg Asn Ile Pro 
    50                  55                  60                  


Arg Arg His Thr Leu Gly Gly Pro Arg Ser Ser Lys Glu Ile Leu Gly 
65                  70                  75                  80  


Met Gln Thr Ser Glu Met Asp Arg Lys Arg Glu Ala Phe Leu Glu His 
                85                  90                  95      


Leu Lys Gln Lys Tyr Pro His His Ala Ser Ala Ile Met Gly His Gln 
            100                 105                 110         


Glu Arg Leu Arg Asp Gln Thr Arg Ser Pro Lys Leu Ser His Ser Pro 
        115                 120                 125             


Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr Ser 
    130                 135                 140                 


Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro Phe 
145                 150                 155                 160 


Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser Thr 
                165                 170                 175     


Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr Gly 
            180                 185                 190         


Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala Asp 
        195                 200                 205             


Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met 
    210                 215                 220                 


Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser 
225                 230                 235                 240 


Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg 
                245                 250                 255     


Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His 
            260                 265                 270         


Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val 
        275                 280                 285             


Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala 
    290                 295                 300                 


His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro 
305                 310                 315                 320 


His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg 
                325                 330                 335     


Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser 
            340                 345                 350         


Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu 
        355                 360                 365             


Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile 
    370                 375                 380                 


Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His 
385                 390                 395                 400 


Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp 
                405                 410                 415     


Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala 
            420                 425                 430         


Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln 
        435                 440                 445             


Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro 
    450                 455                 460                 


Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp 
465                 470                 475                 480 


Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro 
                485                 490                 495     


His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys 
            500                 505                 510         


Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala 
        515                 520                 525             


Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln 
    530                 535                 540                 


Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Ser 
545                 550                 555                 560 


Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr Asp Ser Ala 
                565                 570                 575     


Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala Leu Glu Ser 
            580                 585                 590         


Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser Ala Ile His 
        595                 600                 605             


Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu Arg Leu Gln 
    610                 615                 620                 


Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu Leu Leu Arg 
625                 630                 635                 640 


Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys Val Met Glu 
                645                 650                 655     


Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg Val Leu Val 
            660                 665                 670         


Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys Ile Val Lys 
        675                 680                 685             


Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys Lys Asp Ser 
    690                 695                 700                 


Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu Asp Gly Ala 
705                 710                 715                 720 


Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu Lys Gly Glu 
                725                 730                 735     


Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg Ile Glu Val 
            740                 745                 750         


Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu Asp Ser Leu 
        755                 760                 765             


Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met Leu Arg Arg 
    770                 775                 780                 


His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala Gln Ala Ala 
785                 790                 795                 800 


Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val Leu Lys Ser 
                805                 810                 815     


Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His Ser Thr Gly 
            820                 825                 830         


Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser Gly Met Met 
        835                 840                 845             


Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro Ser Gln His 
    850                 855                 860                 


Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His Val Ala Ser 
865                 870                 875                 880 


Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln Met Ser Gln 
                885                 890                 895     


Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala Met Gln Ser 
            900                 905                 910         


Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn Arg Ala Val 
        915                 920                 925             


Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg Gln Asn Leu 
    930                 935                 940                 


Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu Glu Ala Gln 
945                 950                 955                 960 


Ala Asn Ile Met Lys Ser Ile Pro Asn Leu Glu Met Pro Pro Ala Thr 
                965                 970                 975     


Gly Pro Leu Pro Arg Gly Asp Ala Pro Val Asp Lys Val Glu Leu Ser 
            980                 985                 990         


Asp Ser Pro Asn Ser Glu Gln Asp  Leu Glu Lys Leu Gly  Gly Lys Ser 
        995                 1000                 1005             


Pro Pro  Pro Pro Pro Pro Pro  Pro Arg Arg Ser Tyr  Leu Pro Gly 
    1010                 1015                 1020             


Ser Gly  Leu Thr Thr Thr Arg  Ser Gly Asp Val Val  Tyr Thr Gly 
    1025                 1030                 1035             


Arg Lys  Glu Asn Ile Thr Ala  Lys Ala Ser Ser Glu  Asp Ala Gly 
    1040                 1045                 1050             


Pro Ser  Pro Gln Thr Arg Ala  Thr Lys Tyr Pro Ala  Glu Glu Pro 
    1055                 1060                 1065             


Ala Ser  Ala Trp Thr Pro Ser  Pro Pro Pro Val Thr  Thr Ser Ser 
    1070                 1075                 1080             


Ser Lys  Asp Glu Glu Glu Glu  Glu Glu Glu Gly Asp  Lys Ile Met 
    1085                 1090                 1095             


Ala Glu  Leu Gln Ala Phe Gln  Lys Cys Ser Phe Met  Asp Val Asn 
    1100                 1105                 1110             


Ser Asn  Ser His Ala Glu Pro  Ser Arg Ala Asp Ser  His Val Lys 
    1115                 1120                 1125             


Asp Thr  Arg Ser Gly Ala Thr  Val Pro Pro Lys Glu  Lys Lys Asn 
    1130                 1135                 1140             


Leu Glu  Phe Phe His Glu Asp  Val Arg Lys Ser Asp  Val Glu Tyr 
    1145                 1150                 1155             


Glu Asn  Gly Pro Gln Met Glu  Phe Gln Lys Gly Ser  Ser Gly Ala 
    1160                 1165                 1170             


Pro Gln  Thr Ser Arg Met Pro  Val Pro Met Ser Ala  Lys Asn Arg 
    1175                 1180                 1185             


Pro Gly  Thr Leu Asp Lys Pro  Gly Lys Gln Ser Lys  Leu Gln Asp 
    1190                 1195                 1200             


Pro Arg  Gln Tyr Arg Gln Ala  Asn Gly Ser Ala Lys  Lys Ser Gly 
    1205                 1210                 1215             


Gly Asp  Phe Lys Pro Thr Ser  Pro Ser Leu Pro Ala  Ser Lys Ile 
    1220                 1225                 1230             


Pro Ala  Leu Ser Pro Ser Ser  Gly Lys Ser Ser Ser  Leu Pro Ser 
    1235                 1240                 1245             


Ser Ser  Gly Asp Ser Ser Asn  Leu Pro Asn Pro Pro  Ala Thr Lys 
    1250                 1255                 1260             


Pro Ser  Ile Ala Ser Asn Pro  Leu Ser Pro Gln Thr  Gly Pro Pro 
    1265                 1270                 1275             


Ala His  Ser Ala Ser Leu Ile  Pro Ser Val Ser Asn  Gly Ser Leu 
    1280                 1285                 1290             


Lys Phe  Gln Ser Leu Thr His  Thr Gly Lys Gly His  His Leu Ser 
    1295                 1300                 1305             


Phe Ser  Pro Gln Ser Gln Asn  Gly Arg Ala Pro Pro  Pro Leu Ser 
    1310                 1315                 1320             


Phe Ser  Ser Ser Pro Pro Ser  Pro Ala Ser Ser Val  Ser Leu Asn 
    1325                 1330                 1335             


Gln Gly  Ala Lys Gly Thr Arg  Thr Ile His Thr Pro  Ser Leu Thr 
    1340                 1345                 1350             


Ser Tyr  Lys Ala Gln Asn Gly  Ser Ser Ser Lys Ala  Thr Pro Ser 
    1355                 1360                 1365             


Thr Ala  Lys Glu Thr Ser 
    1370                 


<210> 6498
<211> 1943
<212> PRT
<213> Homo sapiens

<400> 6498
Met Glu Glu Asn Glu Ser Gln Lys Cys Glu Pro Cys Leu Pro Tyr Ser 
1               5                   10                  15      


Ala Asp Arg Arg Gln Met Gln Glu Gln Gly Lys Gly Asn Leu His Val 
            20                  25                  30          


Thr Ser Pro Glu Asp Ala Glu Cys Arg Arg Thr Lys Glu Arg Leu Ser 
        35                  40                  45              


Asn Gly Asn Ser Arg Gly Ser Val Ser Lys Ser Ser Arg Asn Ile Pro 
    50                  55                  60                  


Arg Arg His Thr Leu Gly Gly Pro Arg Ser Ser Lys Glu Ile Leu Gly 
65                  70                  75                  80  


Met Gln Thr Ser Glu Met Asp Arg Lys Arg Glu Ala Phe Leu Glu His 
                85                  90                  95      


Leu Lys Gln Lys Tyr Pro His His Ala Ser Ala Ile Met Gly His Gln 
            100                 105                 110         


Glu Arg Leu Arg Asp Gln Thr Arg Ser Pro Lys Leu Ser His Ser Pro 
        115                 120                 125             


Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr Ser 
    130                 135                 140                 


Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro Phe 
145                 150                 155                 160 


Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser Thr 
                165                 170                 175     


Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr Gly 
            180                 185                 190         


Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala Asp 
        195                 200                 205             


Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met 
    210                 215                 220                 


Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser 
225                 230                 235                 240 


Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg 
                245                 250                 255     


Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His 
            260                 265                 270         


Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val 
        275                 280                 285             


Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala 
    290                 295                 300                 


His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro 
305                 310                 315                 320 


His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg 
                325                 330                 335     


Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser 
            340                 345                 350         


Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu 
        355                 360                 365             


Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile 
    370                 375                 380                 


Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His 
385                 390                 395                 400 


Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp 
                405                 410                 415     


Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala 
            420                 425                 430         


Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln 
        435                 440                 445             


Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro 
    450                 455                 460                 


Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp 
465                 470                 475                 480 


Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro 
                485                 490                 495     


His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys 
            500                 505                 510         


Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala 
        515                 520                 525             


Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln 
    530                 535                 540                 


Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Arg 
545                 550                 555                 560 


Glu Arg Met Gln Ala Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu 
                565                 570                 575     


Val Gln Ser Ala Leu Phe Lys Gly Pro Ile Thr Ser Tyr Ser Lys Asp 
            580                 585                 590         


Ala Ser Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr 
        595                 600                 605             


Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala 
    610                 615                 620                 


Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser 
625                 630                 635                 640 


Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu 
                645                 650                 655     


Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu 
            660                 665                 670         


Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys 
        675                 680                 685             


Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg 
    690                 695                 700                 


Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys 
                725                 730                 735     


Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu 
            740                 745                 750         


Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu 
        755                 760                 765             


Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg 
    770                 775                 780                 


Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu 
785                 790                 795                 800 


Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met 
                805                 810                 815     


Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala 
            820                 825                 830         


Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val 
        835                 840                 845             


Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His 
    850                 855                 860                 


Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser 
865                 870                 875                 880 


Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro 
                885                 890                 895     


Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His 
            900                 905                 910         


Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln 
        915                 920                 925             


Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala 
    930                 935                 940                 


Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn 
945                 950                 955                 960 


Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg 
                965                 970                 975     


Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu 
            980                 985                 990         


Glu Ala Gln Ala Asn Ile Met Lys  Ser Ile Pro Asn Leu  Glu Met Pro 
        995                 1000                 1005             


Pro Ala  Thr Gly Pro Leu Pro  Arg Gly Asp Ala Pro  Val Asp Lys 
    1010                 1015                 1020             


Val Glu  Leu Ser Glu Asp Ser  Pro Asn Ser Glu Gln  Asp Leu Glu 
    1025                 1030                 1035             


Lys Leu  Gly Gly Lys Ser Pro  Pro Pro Pro Pro Pro  Pro Pro Arg 
    1040                 1045                 1050             


Arg Ser  Tyr Leu Pro Gly Ser  Gly Leu Thr Thr Thr  Arg Ser Gly 
    1055                 1060                 1065             


Asp Val  Val Tyr Thr Gly Arg  Lys Glu Asn Ile Thr  Ala Lys Ala 
    1070                 1075                 1080             


Ser Ser  Glu Asp Ala Gly Pro  Ser Pro Gln Thr Arg  Ala Thr Lys 
    1085                 1090                 1095             


Tyr Pro  Ala Glu Glu Pro Ala  Ser Ala Trp Thr Pro  Ser Pro Pro 
    1100                 1105                 1110             


Pro Val  Thr Thr Ser Ser Ser  Lys Asp Glu Glu Glu  Glu Glu Glu 
    1115                 1120                 1125             


Glu Gly  Asp Lys Ile Met Ala  Glu Leu Gln Ala Phe  Gln Lys Cys 
    1130                 1135                 1140             


Ser Phe  Met Asp Val Asn Ser  Asn Ser His Ala Glu  Pro Ser Arg 
    1145                 1150                 1155             


Ala Asp  Ser His Val Lys Asp  Thr Arg Ser Gly Ala  Thr Val Pro 
    1160                 1165                 1170             


Pro Lys  Glu Lys Lys Asn Leu  Glu Phe Phe His Glu  Asp Val Arg 
    1175                 1180                 1185             


Lys Ser  Asp Val Glu Tyr Glu  Asn Gly Pro Gln Met  Glu Phe Gln 
    1190                 1195                 1200             


Lys Val  Thr Thr Gly Ala Val  Arg Pro Ser Asp Pro  Pro Lys Trp 
    1205                 1210                 1215             


Glu Arg  Gly Met Glu Asn Ser  Ile Ser Asp Ala Ser  Arg Thr Ser 
    1220                 1225                 1230             


Glu Tyr  Lys Thr Glu Ile Ile  Met Lys Glu Asn Ser  Ile Ser Asn 
    1235                 1240                 1245             


Met Ser  Leu Leu Arg Asp Ser  Arg Asn Tyr Ser Gln  Glu Thr Val 
    1250                 1255                 1260             


Pro Lys  Ala Ser Phe Gly Phe  Ser Gly Ile Ser Pro  Leu Glu Asp 
    1265                 1270                 1275             


Glu Ile  Asn Lys Gly Ser Lys  Ile Ser Gly Leu Gln  Tyr Ser Ile 
    1280                 1285                 1290             


Pro Asp  Thr Glu Asn Gln Thr  Leu Asn Tyr Gly Lys  Thr Lys Glu 
    1295                 1300                 1305             


Met Glu  Lys Gln Asn Thr Asp  Lys Cys His Val Ser  Ser His Thr 
    1310                 1315                 1320             


Arg Leu  Thr Glu Ser Ser Val  His Asp Phe Lys Thr  Glu Asp Gln 
    1325                 1330                 1335             


Glu Val  Ile Thr Thr Asp Phe  Gly Gln Val Val Leu  Arg Pro Lys 
    1340                 1345                 1350             


Glu Ala  Arg His Ala Asn Val  Asn Pro Asn Glu Asp  Gly Glu Ser 
    1355                 1360                 1365             


Ser Ser  Ser Ser Pro Thr Glu  Glu Asn Ala Ala Thr  Asp Asn Ile 
    1370                 1375                 1380             


Ala Phe  Met Ile Thr Glu Thr  Thr Val Gln Val Leu  Ser Ser Gly 
    1385                 1390                 1395             


Glu Val  His Asp Ile Val Ser  Gln Lys Gly Glu Asp  Ile Gln Thr 
    1400                 1405                 1410             


Val Asn  Ile Asp Ala Arg Lys  Glu Met Thr Pro Arg  Gln Glu Gly 
    1415                 1420                 1425             


Thr Asp  Asn Glu Asp Pro Val  Val Cys Leu Asp Lys  Lys Pro Val 
    1430                 1435                 1440             


Ile Ile  Ile Phe Asp Glu Pro  Met Asp Ile Arg Ser  Ala Tyr Lys 
    1445                 1450                 1455             


Arg Leu  Ser Thr Ile Phe Glu  Glu Cys Asp Glu Glu  Leu Glu Arg 
    1460                 1465                 1470             


Met Met  Met Glu Glu Lys Ile  Glu Glu Glu Glu Glu  Glu Glu Asn 
    1475                 1480                 1485             


Gly Asp  Ser Val Val Gln Asn  Asn Asn Thr Ser Gln  Met Ser His 
    1490                 1495                 1500             


Lys Lys  Val Ala Pro Gly Asn  Leu Arg Thr Gly Gln  Gln Val Glu 
    1505                 1510                 1515             


Thr Lys  Ser Gln Pro His Ser  Leu Ala Thr Glu Thr  Arg Asn Pro 
    1520                 1525                 1530             


Gly Gly  Gln Glu Met Asn Arg  Thr Glu Leu Asn Lys  Phe Ser His 
    1535                 1540                 1545             


Val Asp  Ser Pro Asn Ser Glu  Cys Lys Gly Glu Asp  Ala Thr Asp 
    1550                 1555                 1560             


Asp Gln  Phe Glu Ser Pro Lys  Lys Lys Phe Lys Phe  Lys Phe Pro 
    1565                 1570                 1575             


Lys Lys  Gln Leu Ala Ala Leu  Thr Gln Ala Ile Arg  Thr Gly Thr 
    1580                 1585                 1590             


Lys Thr  Gly Lys Lys Thr Leu  Gln Val Val Val Tyr  Glu Glu Glu 
    1595                 1600                 1605             


Glu Glu  Asp Gly Thr Leu Lys  Gln His Lys Glu Ala  Lys Arg Phe 
    1610                 1615                 1620             


Glu Ile  Ala Arg Ser Gln Pro  Glu Asp Thr Pro Glu  Asn Thr Val 
    1625                 1630                 1635             


Arg Arg  Gln Glu Gln Pro Ser  Ile Glu Ser Thr Ser  Pro Ile Ser 
    1640                 1645                 1650             


Arg Thr  Asp Glu Ile Arg Lys  Asn Thr Tyr Arg Thr  Leu Asp Ser 
    1655                 1660                 1665             


Leu Glu  Gln Thr Ile Lys Gln  Leu Glu Asn Thr Ile  Ser Glu Met 
    1670                 1675                 1680             


Ser Pro  Lys Ala Leu Val Asp  Thr Ser Cys Ser Ser  Asn Arg Asp 
    1685                 1690                 1695             


Ser Val  Ala Ser Ser Ser His  Ile Ala Gln Glu Ala  Ser Pro Arg 
    1700                 1705                 1710             


Pro Leu  Leu Val Pro Asp Glu  Gly Pro Thr Ala Leu  Glu Pro Pro 
    1715                 1720                 1725             


Thr Ser  Ile Pro Ser Ala Ser  Arg Lys Gly Ser Ser  Gly Ala Pro 
    1730                 1735                 1740             


Gln Thr  Ser Arg Met Pro Val  Pro Met Ser Ala Lys  Asn Arg Pro 
    1745                 1750                 1755             


Gly Thr  Leu Asp Lys Pro Gly  Lys Gln Ser Lys Leu  Gln Asp Pro 
    1760                 1765                 1770             


Arg Gln  Tyr Arg Gln Ala Asn  Gly Ser Ala Lys Lys  Ser Gly Gly 
    1775                 1780                 1785             


Asp Phe  Lys Pro Thr Ser Pro  Ser Leu Pro Ala Ser  Lys Ile Pro 
    1790                 1795                 1800             


Ala Leu  Ser Pro Ser Ser Gly  Lys Ser Ser Ser Leu  Pro Ser Ser 
    1805                 1810                 1815             


Ser Gly  Asp Ser Ser Asn Leu  Pro Asn Pro Pro Ala  Thr Lys Pro 
    1820                 1825                 1830             


Ser Ile  Ala Ser Asn Pro Leu  Ser Pro Gln Thr Gly  Pro Pro Ala 
    1835                 1840                 1845             


His Ser  Ala Ser Leu Ile Pro  Ser Val Ser Asn Gly  Ser Leu Lys 
    1850                 1855                 1860             


Phe Gln  Ser Leu Thr His Thr  Gly Lys Gly His His  Leu Ser Phe 
    1865                 1870                 1875             


Ser Pro  Gln Ser Gln Asn Gly  Arg Ala Pro Pro Pro  Leu Ser Phe 
    1880                 1885                 1890             


Ser Ser  Ser Pro Pro Ser Pro  Ala Ser Ser Val Ser  Leu Asn Gln 
    1895                 1900                 1905             


Gly Ala  Lys Gly Thr Arg Thr  Ile His Thr Pro Ser  Leu Thr Ser 
    1910                 1915                 1920             


Tyr Lys  Ala Gln Asn Gly Ser  Ser Ser Lys Ala Thr  Pro Ser Thr 
    1925                 1930                 1935             


Ala Lys  Glu Thr Ser 
    1940             


<210> 6499
<211> 1264
<212> PRT
<213> Homo sapiens

<400> 6499
Met Gln Thr Ser Glu Met Asp Arg Lys Arg Glu Ala Phe Leu Glu His 
1               5                   10                  15      


Leu Lys Gln Lys Tyr Pro His His Ala Ser Ala Ile Met Gly His Gln 
            20                  25                  30          


Glu Arg Leu Arg Asp Gln Thr Arg Ser Pro Lys Leu Ser His Ser Pro 
        35                  40                  45              


Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr Ser 
    50                  55                  60                  


Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro Phe 
65                  70                  75                  80  


Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser Thr 
                85                  90                  95      


Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr Gly 
            100                 105                 110         


Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala Asp 
        115                 120                 125             


Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met 
    130                 135                 140                 


Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser 
145                 150                 155                 160 


Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg 
                165                 170                 175     


Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His 
            180                 185                 190         


Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val 
        195                 200                 205             


Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala 
    210                 215                 220                 


His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro 
225                 230                 235                 240 


His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg 
                245                 250                 255     


Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser 
            260                 265                 270         


Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu 
        275                 280                 285             


Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile 
    290                 295                 300                 


Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His 
305                 310                 315                 320 


Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp 
                325                 330                 335     


Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala 
            340                 345                 350         


Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln 
        355                 360                 365             


Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro 
    370                 375                 380                 


Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp 
385                 390                 395                 400 


Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro 
                405                 410                 415     


His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys 
            420                 425                 430         


Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala 
        435                 440                 445             


Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln 
    450                 455                 460                 


Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Arg 
465                 470                 475                 480 


Glu Arg Met Gln Ala Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu 
                485                 490                 495     


Val Gln Ser Ala Leu Phe Lys Gly Pro Ile Thr Ser Tyr Ser Lys Asp 
            500                 505                 510         


Ala Ser Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr 
        515                 520                 525             


Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala 
    530                 535                 540                 


Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser 
545                 550                 555                 560 


Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu 
                565                 570                 575     


Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu 
            580                 585                 590         


Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys 
        595                 600                 605             


Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg 
    610                 615                 620                 


Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys 
625                 630                 635                 640 


Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys 
                645                 650                 655     


Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu 
            660                 665                 670         


Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu 
        675                 680                 685             


Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg 
    690                 695                 700                 


Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu 
705                 710                 715                 720 


Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met 
                725                 730                 735     


Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala 
            740                 745                 750         


Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val 
        755                 760                 765             


Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His 
    770                 775                 780                 


Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser 
785                 790                 795                 800 


Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro 
                805                 810                 815     


Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His 
            820                 825                 830         


Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln 
        835                 840                 845             


Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala 
    850                 855                 860                 


Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn 
865                 870                 875                 880 


Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg 
                885                 890                 895     


Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu 
            900                 905                 910         


Glu Ala Gln Ala Asn Ile Met Lys Ser Ile Pro Asn Leu Glu Met Pro 
        915                 920                 925             


Pro Ala Thr Gly Pro Leu Pro Arg Gly Asp Ala Pro Val Asp Lys Val 
    930                 935                 940                 


Glu Leu Ser Glu Asp Ser Pro Asn Ser Glu Gln Asp Leu Glu Lys Leu 
945                 950                 955                 960 


Gly Gly Lys Ser Pro Pro Pro Pro Pro Pro Pro Pro Arg Arg Ser Tyr 
                965                 970                 975     


Leu Pro Gly Ser Gly Leu Thr Thr Thr Arg Ser Gly Asp Val Val Tyr 
            980                 985                 990         


Thr Gly Arg Lys Glu Asn Ile Thr  Ala Lys Ala Ser Ser  Glu Asp Ala 
        995                 1000                 1005             


Gly Pro  Ser Pro Gln Thr Arg  Ala Thr Lys Tyr Pro  Ala Glu Glu 
    1010                 1015                 1020             


Pro Ala  Ser Ala Trp Thr Pro  Ser Pro Pro Pro Val  Thr Thr Ser 
    1025                 1030                 1035             


Ser Ser  Lys Asp Glu Glu Glu  Glu Glu Glu Glu Gly  Asp Lys Ile 
    1040                 1045                 1050             


Met Ala  Glu Leu Gln Gly Ser  Ser Gly Ala Pro Gln  Thr Ser Arg 
    1055                 1060                 1065             


Met Pro  Val Pro Met Ser Ala  Lys Asn Arg Pro Gly  Thr Leu Asp 
    1070                 1075                 1080             


Lys Pro  Gly Lys Gln Ser Lys  Leu Gln Asp Pro Arg  Gln Tyr Arg 
    1085                 1090                 1095             


Gln Ala  Asn Gly Ser Ala Lys  Lys Ser Gly Gly Asp  Phe Lys Pro 
    1100                 1105                 1110             


Thr Ser  Pro Ser Leu Pro Ala  Ser Lys Ile Pro Ala  Leu Ser Pro 
    1115                 1120                 1125             


Ser Ser  Gly Lys Ser Ser Ser  Leu Pro Ser Ser Ser  Gly Asp Ser 
    1130                 1135                 1140             


Ser Asn  Leu Pro Asn Pro Pro  Ala Thr Lys Pro Ser  Ile Ala Ser 
    1145                 1150                 1155             


Asn Pro  Leu Ser Pro Gln Thr  Gly Pro Pro Ala His  Ser Ala Ser 
    1160                 1165                 1170             


Leu Ile  Pro Ser Val Ser Asn  Gly Ser Leu Lys Phe  Gln Ser Leu 
    1175                 1180                 1185             


Thr His  Thr Gly Lys Gly His  His Leu Ser Phe Ser  Pro Gln Ser 
    1190                 1195                 1200             


Gln Asn  Gly Arg Ala Pro Pro  Pro Leu Ser Phe Ser  Ser Ser Pro 
    1205                 1210                 1215             


Pro Ser  Pro Ala Ser Ser Val  Ser Leu Asn Gln Gly  Ala Lys Gly 
    1220                 1225                 1230             


Thr Arg  Thr Ile His Thr Pro  Ser Leu Thr Ser Tyr  Lys Ala Gln 
    1235                 1240                 1245             


Asn Gly  Ser Ser Ser Lys Ala  Thr Pro Ser Thr Ala  Lys Glu Thr 
    1250                 1255                 1260             


Ser 
    


<210> 6500
<211> 176
<212> PRT
<213> Homo sapiens

<400> 6500
Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Gly Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly 
            20                  25                  30          


Ser Ser Cys Cys Val Pro Ile Cys Cys Cys Lys Pro Val Cys Cys Cys 
        35                  40                  45              


Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys 
    50                  55                  60                  


Gly Gly Cys Gly Ser Cys Gly Ser Ser Lys Gly Gly Cys Gly Ser Cys 
65                  70                  75                  80  


Gly Cys Ser Gln Ser Asn Cys Cys Lys Pro Cys Cys Ser Ser Ser Gly 
                85                  90                  95      


Cys Gly Ser Phe Cys Cys Gln Ser Ser Cys Ser Lys Pro Cys Cys Cys 
            100                 105                 110         


Gln Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln 
        115                 120                 125             


Ser Ser Cys Cys Gln Ser Ser Cys Phe Lys Pro Cys Cys Cys Gln Ser 
    130                 135                 140                 


Ser Cys Cys Val Pro Val Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys 
145                 150                 155                 160 


Cys Ser Gln Ser Ser Cys Cys Val Pro Ile Cys Cys Gln Tyr Lys Ile 
                165                 170                 175     


<210> 6501
<211> 170
<212> PRT
<213> Homo sapiens

<400> 6501
Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Tyr Gly 
            20                  25                  30          


Ser Gly Cys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Val Cys Cys 
        35                  40                  45              


Cys Lys Pro Val Cys Cys Cys Val Pro Ala Cys Ser Cys Ser Ser Cys 
    50                  55                  60                  


Gly Ser Cys Gly Gly Ser Lys Gly Asp Cys Gly Cys Gly Ser Cys Gly 
65                  70                  75                  80  


Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln Cys Asn Cys 
                85                  90                  95      


Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Cys Cys Gln Ser 
            100                 105                 110         


Ser Cys Cys Asn Pro Cys Cys Cys Gln Ser Ser Cys Cys Val Pro Val 
        115                 120                 125             


Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln Ser Ser Cys 
    130                 135                 140                 


Cys Val Pro Ser Ser Cys Cys Arg Ser Cys Cys Ser Lys Ser Ser Cys 
145                 150                 155                 160 


Cys Val Pro Ile Cys Cys Gln Tyr Lys Ile 
                165                 170 


<210> 6502
<211> 722
<212> PRT
<213> Homo sapiens

<400> 6502
Met Ile Asp Ser Val Lys Leu Arg Arg Asp Ser Ala Ala Asp Phe Phe 
1               5                   10                  15      


Ser His Tyr Glu Tyr Leu Cys Ala Leu Gln Asn Ser Val Pro Leu Pro 
            20                  25                  30          


Ala Val Arg Ala Cys Leu Arg Glu Gly Val Leu Asp Phe Asn Ala Asp 
        35                  40                  45              


Arg Leu Arg Gly Val Asp Trp Ala Pro Leu Leu Ser Thr Leu Lys Ile 
    50                  55                  60                  


Asn Lys Asp Leu Pro Leu Val Ser Ile Lys Ser Phe Phe Gln Pro Trp 
65                  70                  75                  80  


Leu Gly Asp Thr Gly Ser Asp Met Asn Lys Phe Cys Arg Ser Arg Val 
                85                  90                  95      


Pro Ala Ile Arg Tyr Lys Asp Val Thr Phe Gln Leu Cys Lys Ala Leu 
            100                 105                 110         


Lys Gly Cys Leu Ser Ile Ser Ser Val Leu Lys Asn Leu Glu Leu Asn 
        115                 120                 125             


Gly Leu Ile Leu Arg Glu Arg Asp Leu Thr Ile Leu Ala Lys Gly Leu 
    130                 135                 140                 


Asn Lys Ser Ala Ser Leu Val His Leu Ser Leu Ala Asn Cys Pro Ile 
145                 150                 155                 160 


Gly Asp Gly Gly Leu Glu Ile Ile Cys Gln Gly Ile Lys Ser Ser Ile 
                165                 170                 175     


Thr Leu Lys Thr Val Asn Phe Thr Gly Cys Asn Leu Thr Trp Gln Gly 
            180                 185                 190         


Ala Asp His Met Ala Lys Ile Leu Lys Tyr Gln Thr Met Arg Arg His 
        195                 200                 205             


Glu Glu Thr Trp Ala Glu Ser Leu Arg Tyr Arg Arg Pro Asp Leu Asp 
    210                 215                 220                 


Cys Met Ala Gly Leu Arg Arg Ile Thr Leu Asn Cys Asn Thr Leu Ile 
225                 230                 235                 240 


Gly Asp Leu Gly Ala Cys Ala Phe Ala Asp Ser Leu Ser Glu Asp Leu 
                245                 250                 255     


Trp Leu Arg Ala Leu Asp Leu Gln Gln Cys Gly Leu Thr Asn Glu Gly 
            260                 265                 270         


Ala Lys Ala Leu Leu Glu Ala Leu Glu Thr Asn Thr Thr Leu Val Val 
        275                 280                 285             


Leu Asp Ile Arg Lys Asn Pro Leu Ile Asp His Ser Met Met Lys Ala 
    290                 295                 300                 


Val Ile Lys Lys Val Leu Gln Asn Gly Arg Ser Ala Lys Ser Glu Tyr 
305                 310                 315                 320 


Gln Trp Ile Thr Ser Pro Ser Val Lys Glu Pro Ser Lys Thr Ala Lys 
                325                 330                 335     


Gln Lys Arg Arg Thr Ile Ile Leu Gly Ser Gly His Lys Gly Lys Ala 
            340                 345                 350         


Thr Ile Arg Ile Val Gly Leu Ala Thr Lys Lys Pro Val Ser Ser Gly 
        355                 360                 365             


Arg Lys His Ser Leu Gly Lys Glu Tyr Tyr Ala Pro Ala Pro Leu Pro 
    370                 375                 380                 


Pro Gly Val Ser Gly Phe Leu Pro Trp Arg Thr Ala Glu Arg Ala Lys 
385                 390                 395                 400 


Arg His Arg Gly Phe Pro Leu Ile Lys Thr Arg Asp Ile Cys Asn Gln 
                405                 410                 415     


Leu Gln Gln Pro Gly Phe Pro Val Thr Val Thr Val Glu Ser Pro Ser 
            420                 425                 430         


Ser Ser Glu Val Glu Glu Val Asp Asp Ser Ser Glu Ser Val His Glu 
        435                 440                 445             


Val Pro Glu Lys Thr Ser Ile Glu Gln Glu Ala Leu Gln Glu Lys Leu 
    450                 455                 460                 


Glu Glu Cys Leu Lys Gln Leu Lys Glu Glu Arg Val Ile Arg Leu Lys 
465                 470                 475                 480 


Val Asp Lys Arg Val Ser Glu Leu Glu His Glu Asn Ala Gln Leu Arg 
                485                 490                 495     


Asn Ile Asn Phe Ser Leu Ser Glu Ala Leu His Ala Gln Ser Leu Thr 
            500                 505                 510         


Asn Met Ile Leu Asp Asp Glu Gly Val Leu Gly Ser Ile Glu Asn Ser 
        515                 520                 525             


Phe Gln Lys Phe His Ala Phe Leu Asp Leu Leu Lys Asp Ala Gly Leu 
    530                 535                 540                 


Gly Gln Leu Ala Thr Met Ala Gly Ile Asp Gln Ser Asp Phe Gln Leu 
545                 550                 555                 560 


Leu Gly His Pro Gln Met Thr Ser Thr Val Ser Asn Pro Pro Lys Glu 
                565                 570                 575     


Glu Lys Lys Ala Leu Glu Asp Glu Lys Pro Glu Pro Lys Gln Asn Ala 
            580                 585                 590         


Leu Gly Gln Met Gln Asn Ile Gln Val Ser Ile Cys Met Gln Ser Ala 
        595                 600                 605             


Tyr Asn Glu Gly Thr Leu Met Lys Phe Gln Lys Ile Thr Gly Asp Ala 
    610                 615                 620                 


Arg Ile Pro Leu Pro Leu Asp Ser Phe Pro Val Pro Val Ser Thr Pro 
625                 630                 635                 640 


Glu Gly Leu Gly Thr Ser Ser Asn Asn Leu Gly Val Pro Ala Thr Glu 
                645                 650                 655     


Gln Arg Gln Glu Ser Phe Glu Gly Phe Ile Ala Arg Met Cys Ser Pro 
            660                 665                 670         


Ser Pro Asp Ala Thr Ser Gly Thr Gly Ser Gln Arg Lys Glu Glu Glu 
        675                 680                 685             


Leu Ser Arg Asn Ser Arg Ser Ser Ser Glu Lys Lys Thr Lys Thr Gly 
    690                 695                 700                 


Glu Tyr Thr Lys Lys His Ser Asp Lys Gln His Pro Gly Lys Asp Leu 
705                 710                 715                 720 


His Ser 
        


<210> 6503
<211> 373
<212> PRT
<213> Homo sapiens

<400> 6503
Met Ala Leu Asn Val Ala Pro Val Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Gln Phe Gln Arg Gly Thr Cys Ser Arg Ser Asp Glu 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Pro Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Thr His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Thr Ala Ala Ala Met 
                85                  90                  95      


Leu Ala Gln Gln Met Gln Phe Met Phe Pro Gly Thr Pro Leu His Pro 
            100                 105                 110         


Val Pro Thr Phe Pro Val Gly Pro Ala Ile Gly Thr Asn Thr Ala Ile 
        115                 120                 125             


Ser Phe Ala Pro Tyr Leu Ala Pro Val Thr Pro Gly Val Gly Leu Val 
    130                 135                 140                 


Pro Thr Glu Ile Leu Pro Thr Thr Pro Val Ile Val Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Val Thr Val Pro Gly Ser Thr Ala Thr Gln Lys Leu Leu Arg Thr 
                165                 170                 175     


Asp Lys Leu Glu Val Cys Arg Glu Phe Gln Arg Gly Asn Cys Ala Arg 
            180                 185                 190         


Gly Glu Thr Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile 
        195                 200                 205             


Asp Thr Ser Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly 
    210                 215                 220                 


Arg Cys Met Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu 
225                 230                 235                 240 


Gln Ala Lys Ile Lys Ala Ala Gln His Gln Ala Asn Gln Ala Ala Val 
                245                 250                 255     


Ala Ala Gln Ala Ala Ala Ala Ala Ala Thr Val Met Ala Phe Pro Pro 
            260                 265                 270         


Gly Ala Leu His Pro Leu Pro Lys Arg Gln Ala Leu Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ser Ala Val Phe Asn Pro Ser Val Leu His Tyr Gln Gln Ala 
    290                 295                 300                 


Leu Thr Ser Ala Gln Leu Gln Gln His Ala Ala Phe Ile Pro Thr Gly 
305                 310                 315                 320 


Ser Val Leu Cys Met Thr Pro Ala Thr Ser Ile Asp Asn Ser Glu Ile 
                325                 330                 335     


Ile Ser Arg Asn Gly Met Glu Cys Gln Glu Ser Ala Leu Arg Ile Thr 
            340                 345                 350         


Lys His Cys Tyr Cys Thr Tyr Tyr Pro Val Ser Ser Ser Ile Glu Leu 
        355                 360                 365             


Pro Gln Thr Ala Cys 
    370             


<210> 6504
<211> 106
<212> PRT
<213> Homo sapiens

<400> 6504
Met Thr Gln Ser Thr Ala Lys Ala Met Lys Arg Pro Leu Glu Ala Thr 
1               5                   10                  15      


Val Asp Leu Ala Phe Pro Pro Gly Ala Leu His Pro Leu Pro Lys Arg 
            20                  25                  30          


Gln Ala Leu Glu Lys Ser Asn Gly Thr Ser Ala Val Phe Asn Pro Ser 
        35                  40                  45              


Val Leu His Tyr Gln Gln Ala Leu Thr Ser Ala Gln Leu Gln Gln His 
    50                  55                  60                  


Ala Ala Phe Ile Pro Thr Val Pro Met Met His Ser Ala Thr Ser Ala 
65                  70                  75                  80  


Thr Val Ser Ala Ala Thr Thr Pro Ala Thr Ser Val Pro Phe Ala Ala 
                85                  90                  95      


Thr Ala Thr Ala Asn Gln Leu Val Tyr Ser 
            100                 105     


<210> 6505
<211> 304
<212> PRT
<213> Homo sapiens

<400> 6505
Met Ala Lys Ile Glu Lys Asn Ala Pro Thr Met Glu Lys Lys Pro Glu 
1               5                   10                  15      


Leu Phe Asn Ile Met Glu Val Asp Gly Val Pro Thr Leu Ile Leu Ser 
            20                  25                  30          


Lys Glu Trp Trp Glu Lys Val Cys Asn Phe Gln Ala Lys Pro Asp Asp 
        35                  40                  45              


Leu Ile Leu Ala Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met His Glu 
    50                  55                  60                  


Ile Leu Asp Met Ile Leu Asn Asp Gly Asp Val Glu Lys Cys Lys Arg 
65                  70                  75                  80  


Ala Gln Thr Leu Asp Arg His Ala Phe Leu Glu Leu Lys Phe Pro His 
                85                  90                  95      


Lys Glu Lys Pro Asp Leu Glu Phe Val Leu Glu Met Ser Ser Pro Gln 
            100                 105                 110         


Leu Ile Lys Thr His Leu Pro Ser His Leu Ile Pro Pro Ser Ile Trp 
        115                 120                 125             


Lys Glu Asn Cys Lys Ile Val Tyr Val Ala Arg Asn Pro Lys Asp Cys 
    130                 135                 140                 


Leu Val Ser Tyr Tyr His Phe His Arg Met Ala Ser Phe Met Pro Asp 
145                 150                 155                 160 


Pro Gln Asn Leu Glu Glu Phe Tyr Glu Lys Phe Met Ser Gly Lys Val 
                165                 170                 175     


Val Gly Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp Ala Ala Lys 
            180                 185                 190         


Asp Met His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Ile Lys Lys Asn 
        195                 200                 205             


Pro Lys His Glu Ile His Lys Val Leu Glu Phe Leu Glu Lys Thr Trp 
    210                 215                 220                 


Ser Gly Asp Val Ile Asn Lys Ile Val His His Thr Ser Phe Asp Val 
225                 230                 235                 240 


Met Lys Asp Asn Pro Met Ala Asn His Thr Ala Val Pro Ala His Ile 
                245                 250                 255     


Phe Asn His Ser Ile Ser Lys Phe Met Arg Lys Gly Met Pro Gly Asp 
            260                 265                 270         


Trp Lys Asn His Phe Thr Val Ala Leu Asn Glu Asn Phe Asp Lys His 
        275                 280                 285             


Tyr Glu Lys Lys Met Ala Gly Ser Thr Leu Asn Phe Cys Leu Glu Ile 
    290                 295                 300                 


<210> 6506
<211> 395
<212> PRT
<213> Homo sapiens

<400> 6506
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210> 6507
<211> 481
<212> PRT
<213> Homo sapiens

<400> 6507
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Asn Leu Pro Asn His 
    290                 295                 300                 


Leu Val Ile Pro Thr Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 6508
<211> 867
<212> PRT
<213> Homo sapiens

<400> 6508
Met Gln Ala Glu Ala Ala Asp Trp Phe Ser Ser Met Pro Phe Gln Lys 
1               5                   10                  15      


His Val Tyr Tyr Pro Leu Ala Ser Gly Pro Glu Gly Pro Asp Val Ala 
            20                  25                  30          


Val Ala Ala Ala Ala Ala Gly Ala Ala Ser Met Ala Cys Ala Pro Pro 
        35                  40                  45              


Ser Ala Ala Ser Gly Pro Leu Pro Phe Phe Gln Phe Arg Pro Arg Leu 
    50                  55                  60                  


Glu Ser Val Asp Trp Arg Arg Leu Ser Ala Ile Asp Val Asp Lys Val 
65                  70                  75                  80  


Ala Gly Ala Val Asp Val Leu Thr Leu Gln Glu Asn Ile Met Asn Ile 
                85                  90                  95      


Thr Phe Cys Lys Leu Glu Asp Glu Lys Cys Pro His Cys Gln Ser Gly 
            100                 105                 110         


Val Asp Pro Val Leu Leu Lys Leu Ile Arg Leu Ala Gln Phe Thr Ile 
        115                 120                 125             


Glu Tyr Leu Leu His Ser Gln Glu Phe Leu Thr Ser Gln Leu His Thr 
    130                 135                 140                 


Leu Glu Glu Arg Leu Arg Leu Ser His Cys Asp Gly Glu Gln Ser Lys 
145                 150                 155                 160 


Lys Leu Leu Thr Lys Gln Ala Gly Glu Ile Lys Thr Leu Lys Glu Glu 
                165                 170                 175     


Cys Lys Arg Arg Lys Lys Met Ile Ser Thr Gln Gln Leu Met Ile Glu 
            180                 185                 190         


Ala Lys Ala Asn Tyr Tyr Gln Cys His Phe Cys Asp Lys Ala Phe Met 
        195                 200                 205             


Asn Gln Ala Phe Leu Gln Ser His Ile Gln Arg Arg His Thr Glu Glu 
    210                 215                 220                 


Asn Ser His Phe Glu Tyr Gln Lys Asn Ala Gln Ile Glu Lys Leu Arg 
225                 230                 235                 240 


Ser Glu Ile Val Val Leu Lys Glu Glu Leu Gln Leu Thr Arg Ser Glu 
                245                 250                 255     


Leu Glu Ala Ala His His Ala Ser Ala Val Arg Phe Ser Lys Glu Tyr 
            260                 265                 270         


Glu Met Gln Lys Thr Lys Glu Glu Asp Phe Leu Lys Leu Phe Asp Arg 
        275                 280                 285             


Trp Lys Glu Glu Glu Lys Glu Lys Leu Val Asp Glu Met Glu Lys Val 
    290                 295                 300                 


Lys Glu Met Phe Met Lys Glu Phe Lys Glu Leu Thr Ser Lys Asn Ser 
305                 310                 315                 320 


Ala Leu Glu Tyr Gln Leu Ser Glu Ile Gln Lys Ser Asn Met Gln Ile 
                325                 330                 335     


Lys Ser Asn Ile Gly Thr Leu Lys Asp Ala His Glu Phe Lys Glu Asp 
            340                 345                 350         


Arg Ser Pro Tyr Pro Gln Asp Phe His Asn Val Met Gln Leu Leu Asp 
        355                 360                 365             


Ser Gln Glu Ser Lys Trp Thr Ala Arg Val Gln Ala Ile His Gln Glu 
    370                 375                 380                 


His Lys Lys Glu Lys Gly Arg Leu Leu Ser His Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Thr Ser Met Ile Asp Asp Leu Asn Ala Ser Asn Val Phe Tyr Lys Lys 
                405                 410                 415     


Arg Ile Glu Glu Leu Gly Gln Arg Leu Gln Glu Gln Asn Glu Leu Ile 
            420                 425                 430         


Ile Thr Gln Arg Gln Gln Ile Lys Asp Phe Thr Cys Asn Pro Leu Asn 
        435                 440                 445             


Ser Ile Ser Glu Pro Lys Gly Asn Pro Leu Ala Trp Gln Ala Phe Glu 
    450                 455                 460                 


Ser Gln Pro Ala Ala Pro Ala Val Pro Met Asn Ala Pro Ala Leu His 
465                 470                 475                 480 


Thr Leu Glu Thr Lys Ser Ser Leu Pro Met Val His Glu Gln Ala Phe 
                485                 490                 495     


Ser Ser His Ile Leu Glu Pro Ile Glu Glu Leu Ser Glu Glu Glu Lys 
            500                 505                 510         


Gly Arg Glu Asn Glu Gln Lys Leu Asn Asn Asn Lys Met His Leu Arg 
        515                 520                 525             


Lys Ala Leu Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met 
    530                 535                 540                 


Val Glu Gln Asn Leu Met Glu Lys Leu Glu Thr Leu Gly Ile Asn Ala 
545                 550                 555                 560 


Asp Ile Arg Gly Ile Ser Ser Asp Gln Leu His Arg Val Leu Lys Ser 
                565                 570                 575     


Val Glu Ser Glu Arg His Lys Gln Glu Arg Glu Ile Pro Asn Phe His 
            580                 585                 590         


Gln Ile Arg Glu Phe Leu Glu His Gln Val Ser Cys Lys Ile Glu Glu 
        595                 600                 605             


Lys Ala Leu Leu Ser Ser Asp Gln Cys Ser Val Ser Gln Met Asp Thr 
    610                 615                 620                 


Leu Ser Thr Gly Glu Val Pro Lys Met Ile Gln Leu Pro Ser Lys Asn 
625                 630                 635                 640 


Arg Gln Leu Ile Arg Gln Lys Ala Val Ser Thr Asp Arg Thr Ser Val 
                645                 650                 655     


Pro Lys Ile Lys Lys Asn Val Met Glu Asp Pro Phe Pro Arg Lys Ser 
            660                 665                 670         


Ser Thr Ile Thr Thr Pro Pro Phe Ser Ser Glu Glu Glu Gln Glu Asp 
        675                 680                 685             


Asp Asp Leu Ile Arg Ala Tyr Ala Ser Pro Gly Pro Leu Pro Val Pro 
    690                 695                 700                 


Pro Pro Gln Asn Lys Gly Ser Phe Gly Lys Asn Thr Val Lys Ser Asp 
705                 710                 715                 720 


Ala Asp Gly Thr Glu Gly Ser Glu Ile Glu Asp Thr Asp Asp Ser Pro 
                725                 730                 735     


Lys Pro Ala Gly Val Ala Val Lys Thr Pro Thr Glu Lys Val Glu Lys 
            740                 745                 750         


Met Phe Pro His Arg Lys Asn Val Asn Lys Pro Val Gly Gly Thr Asn 
        755                 760                 765             


Val Pro Glu Met Phe Ile Lys Lys Glu Glu Leu Gln Glu Leu Lys Cys 
    770                 775                 780                 


Ala Asp Val Glu Asp Glu Asp Trp Asp Ile Ser Ser Leu Glu Glu Glu 
785                 790                 795                 800 


Ile Ser Leu Gly Lys Lys Ser Gly Lys Glu Gln Lys Glu Pro Pro Pro 
                805                 810                 815     


Ala Lys Asn Glu Pro His Phe Ala His Val Leu Asn Ala Trp Gly Ala 
            820                 825                 830         


Phe Asn Pro Lys Gly Pro Lys Gly Glu Gly Leu Gln Glu Asn Glu Ser 
        835                 840                 845             


Ser Thr Leu Lys Ser Ser Leu Val Thr Val Thr Asp Trp Ser Asp Thr 
    850                 855                 860                 


Ser Asp Val 
865         


<210> 6509
<211> 92
<212> PRT
<213> Homo sapiens

<400> 6509
Met Ala Thr Pro Pro Lys Arg Arg Ala Val Glu Ala Thr Gly Glu Lys 
1               5                   10                  15      


Val Leu Arg Tyr Glu Thr Phe Ile Ser Asp Val Leu Gln Arg Asp Leu 
            20                  25                  30          


Arg Lys Val Leu Asp His Arg Asp Lys Val Tyr Glu Gln Leu Ala Lys 
        35                  40                  45              


Tyr Leu Gln Leu Arg Asn Val Ile Glu Arg Leu Gln Val Lys Thr Met 
    50                  55                  60                  


Gly Leu Gly Thr Ile Phe Leu Val Cys Val Gly Lys Gly Gly Lys Trp 
65                  70                  75                  80  


Glu Glu Arg Leu Gln Thr Gln Pro Cys His Leu Thr 
                85                  90          


<210> 6510
<211> 843
<212> PRT
<213> Homo sapiens

<400> 6510
Met Ala Val Glu Asp Ser Thr Leu Gln Val Val Val Arg Val Arg Pro 
1               5                   10                  15      


Pro Thr Pro Arg Glu Leu Asp Ser Gln Arg Arg Pro Val Val Gln Val 
            20                  25                  30          


Val Asp Glu Arg Val Leu Val Phe Asn Pro Glu Glu Pro Asp Gly Gly 
        35                  40                  45              


Phe Pro Gly Leu Lys Trp Gly Gly Thr His Asp Gly Pro Lys Lys Lys 
    50                  55                  60                  


Gly Lys Asp Leu Thr Phe Val Phe Asp Arg Val Phe Gly Glu Ala Ala 
65                  70                  75                  80  


Thr Gln Gln Asp Val Phe Gln His Thr Thr His Ser Val Leu Asp Ser 
                85                  90                  95      


Phe Leu Gln Gly Tyr Asn Cys Ser Val Phe Ala Tyr Gly Ala Thr Gly 
            100                 105                 110         


Ala Gly Lys Thr His Thr Met Leu Gly Arg Glu Gly Asp Pro Gly Ile 
        115                 120                 125             


Met Tyr Leu Thr Thr Val Glu Leu Tyr Arg Arg Leu Glu Ala Arg Gln 
    130                 135                 140                 


Gln Glu Lys His Phe Glu Val Leu Ile Ser Tyr Gln Glu Val Tyr Asn 
145                 150                 155                 160 


Glu Gln Ile His Asp Leu Leu Glu Pro Lys Gly Pro Leu Ala Ile Arg 
                165                 170                 175     


Glu Asp Pro Asp Lys Gly Val Val Val Gln Gly Leu Ser Phe His Gln 
            180                 185                 190         


Pro Ala Ser Ala Glu Gln Leu Leu Glu Ile Leu Thr Arg Gly Asn Arg 
        195                 200                 205             


Asn Arg Thr Gln His Pro Thr Asp Ala Asn Ala Thr Ser Ser Arg Ser 
    210                 215                 220                 


His Ala Ile Phe Gln Ile Phe Val Lys Gln Gln Asp Arg Val Pro Gly 
225                 230                 235                 240 


Leu Thr Gln Ala Val Gln Val Ala Lys Met Ser Leu Ile Asp Leu Ala 
                245                 250                 255     


Gly Ser Glu Arg Ala Ser Ser Thr His Ala Lys Gly Glu Arg Leu Arg 
            260                 265                 270         


Glu Gly Ala Asn Ile Asn Arg Ser Leu Leu Ala Leu Ile Asn Val Leu 
        275                 280                 285             


Asn Ala Leu Ala Asp Ala Lys Gly Arg Lys Thr His Val Pro Tyr Arg 
    290                 295                 300                 


Asp Ser Lys Leu Thr Arg Leu Leu Lys Asp Ser Leu Gly Gly Asn Cys 
305                 310                 315                 320 


Arg Thr Val Met Ile Ala Ala Ile Ser Pro Ser Ser Leu Thr Tyr Glu 
                325                 330                 335     


Asp Thr Tyr Asn Thr Leu Lys Tyr Ala Asp Arg Ala Lys Glu Ile Arg 
            340                 345                 350         


Leu Ser Leu Lys Ser Asn Val Thr Ser Leu Asp Cys His Ile Ser Gln 
        355                 360                 365             


Tyr Ala Thr Ile Cys Gln Gln Leu Gln Ala Glu Val Ala Ala Leu Arg 
    370                 375                 380                 


Lys Lys Leu Gln Val Tyr Glu Gly Gly Gly Gln Pro Pro Pro Gln Asp 
385                 390                 395                 400 


Leu Pro Gly Ser Pro Lys Ser Gly Pro Pro Pro Glu His Leu Pro Ser 
                405                 410                 415     


Ser Pro Leu Pro Pro His Pro Pro Ser Gln Pro Cys Thr Pro Glu Leu 
            420                 425                 430         


Pro Ala Gly Pro Arg Ala Leu Gln Glu Glu Ser Leu Gly Met Glu Ala 
        435                 440                 445             


Gln Val Glu Arg Ala Met Glu Gly Asn Ser Ser Asp Gln Glu Gln Ser 
    450                 455                 460                 


Pro Glu Asp Glu Asp Glu Gly Pro Ala Glu Glu Val Pro Thr Gln Met 
465                 470                 475                 480 


Pro Glu Gln Asn Pro Thr His Ala Leu Pro Glu Ser Pro Arg Leu Thr 
                485                 490                 495     


Leu Gln Pro Lys Pro Val Val Gly His Phe Ser Ala Arg Glu Leu Asp 
            500                 505                 510         


Gly Asp Arg Ser Lys Gln Leu Ala Leu Lys Val Leu Cys Val Ala Gln 
        515                 520                 525             


Arg Gln Tyr Ser Leu Leu Gln Ala Ala Asn Leu Leu Thr Pro Asp Met 
    530                 535                 540                 


Ile Thr Glu Phe Glu Thr Leu Gln Gln Leu Val Gln Glu Glu Lys Ile 
545                 550                 555                 560 


Glu Pro Gly Ala Glu Ala Leu Arg Thr Ser Gly Leu Ala Arg Gly Ala 
                565                 570                 575     


Pro Leu Ala Gln Glu Leu Cys Ser Glu Ser Ile Pro Val Pro Ser Pro 
            580                 585                 590         


Leu Cys Pro Glu Pro Pro Gly Tyr Thr Gly Pro Val Thr Arg Thr Met 
        595                 600                 605             


Ala Arg Arg Leu Ser Gly Pro Leu His Thr Leu Gly Ile Pro Pro Gly 
    610                 615                 620                 


Pro Asn Cys Thr Pro Ala Gln Gly Ser Arg Trp Pro Met Glu Lys Lys 
625                 630                 635                 640 


Arg Arg Arg Pro Ser Ala Leu Glu Ala Asp Ser Pro Met Ala Pro Lys 
                645                 650                 655     


Arg Gly Thr Lys Arg Gln Arg Gln Ser Phe Leu Pro Cys Leu Arg Arg 
            660                 665                 670         


Gly Ser Leu Pro Asp Thr Gln Pro Ser Gln Gly Pro Ser Thr Pro Lys 
        675                 680                 685             


Gly Glu Arg Ala Ser Ser Pro Cys His Ser Pro Arg Val Cys Pro Ala 
    690                 695                 700                 


Thr Val Ile Lys Ser Arg Val Pro Leu Gly Pro Ser Ala Met Gln Asn 
705                 710                 715                 720 


Cys Ser Thr Pro Leu Ala Leu Pro Thr Arg Asp Leu Asn Ala Thr Phe 
                725                 730                 735     


Asp Leu Ser Glu Glu Pro Pro Ser Lys Pro Ser Phe His Glu Cys Ile 
            740                 745                 750         


Gly Trp Asp Lys Ile Pro Gln Glu Leu Ser Arg Leu Asp Gln Pro Phe 
        755                 760                 765             


Ile Pro Arg Ala Pro Val Pro Leu Phe Thr Met Lys Gly Pro Lys Pro 
    770                 775                 780                 


Thr Ser Ser Leu Pro Gly Thr Ser Ala Cys Lys Lys Lys Arg Val Ala 
785                 790                 795                 800 


Ser Ser Ser Val Ser His Gly Arg Ser Arg Ile Ala Arg Leu Pro Ser 
                805                 810                 815     


Ser Thr Leu Lys Arg Pro Gly Pro Leu Tyr Ser Gln Val Thr Gly Thr 
            820                 825                 830         


Arg Asp Arg Asp Ser Leu Gly His Gly Gly Arg 
        835                 840             


<210> 6511
<211> 186
<212> PRT
<213> Homo sapiens

<400> 6511
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
            20                  25                  30          


Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
    130                 135                 140                 


Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Thr Pro Gln Gly Pro Arg 
            180                 185     


<210> 6512
<211> 606
<212> PRT
<213> Homo sapiens

<400> 6512
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
            20                  25                  30          


Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
    130                 135                 140                 


Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys 
            180                 185                 190         


Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
        195                 200                 205             


Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
    210                 215                 220                 


Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser 
225                 230                 235                 240 


Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly 
                245                 250                 255     


Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
            260                 265                 270         


Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
        275                 280                 285             


Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
    290                 295                 300                 


Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser 
305                 310                 315                 320 


Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                325                 330                 335     


Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys 
            340                 345                 350         


Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu 
        355                 360                 365             


Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp 
    370                 375                 380                 


Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg 
385                 390                 395                 400 


Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly 
                405                 410                 415     


Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
            420                 425                 430         


Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe 
        435                 440                 445             


Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu 
    450                 455                 460                 


Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
465                 470                 475                 480 


Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                485                 490                 495     


Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile 
            500                 505                 510         


Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
        515                 520                 525             


Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
    530                 535                 540                 


Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
545                 550                 555                 560 


Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                565                 570                 575     


Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp 
            580                 585                 590         


Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
        595                 600                 605     


<210> 6513
<211> 1011
<212> PRT
<213> Homo sapiens

<400> 6513
Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
                565                 570                 575     


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
            580                 585                 590         


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
        595                 600                 605             


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
    610                 615                 620                 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
625                 630                 635                 640 


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
                645                 650                 655     


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
            660                 665                 670         


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
        675                 680                 685             


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
    690                 695                 700                 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
705                 710                 715                 720 


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
                725                 730                 735     


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
            740                 745                 750         


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
        755                 760                 765             


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
    770                 775                 780                 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
785                 790                 795                 800 


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
                805                 810                 815     


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
            820                 825                 830         


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
        835                 840                 845             


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
    850                 855                 860                 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
865                 870                 875                 880 


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
                885                 890                 895     


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
            900                 905                 910         


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
        915                 920                 925             


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
    930                 935                 940                 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
945                 950                 955                 960 


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
                965                 970                 975     


Leu Leu Asn Ser Gln Gln Leu Thr Pro Val His Arg His Pro His Phe 
            980                 985                 990         


Thr Gln Leu Pro Pro Thr His Phe  Ser Pro Ser Met Glu  Ile Met Gln 
        995                 1000                 1005             


Val Arg  Lys 
    1010     


<210> 6514
<211> 1027
<212> PRT
<213> Homo sapiens

<400> 6514
Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Asp Arg Gly Asp Ser Ser Thr Leu Thr Lys 
                565                 570                 575     


Gln Glu Leu Lys Phe Ile Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
            580                 585                 590         


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
        595                 600                 605             


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
    610                 615                 620                 


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
625                 630                 635                 640 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
                645                 650                 655     


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
            660                 665                 670         


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
        675                 680                 685             


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
    690                 695                 700                 


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
705                 710                 715                 720 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
                725                 730                 735     


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
            740                 745                 750         


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
        755                 760                 765             


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
    770                 775                 780                 


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
785                 790                 795                 800 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
                805                 810                 815     


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
            820                 825                 830         


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
        835                 840                 845             


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
    850                 855                 860                 


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
865                 870                 875                 880 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
                885                 890                 895     


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
            900                 905                 910         


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
        915                 920                 925             


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
    930                 935                 940                 


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
945                 950                 955                 960 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
                965                 970                 975     


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
            980                 985                 990         


Leu Leu Asn Ser Gln Gln Leu Thr  Pro Val His Arg His  Pro His Phe 
        995                 1000                 1005             


Thr Gln  Leu Pro Pro Thr His  Phe Ser Pro Ser Met  Glu Ile Met 
    1010                 1015                 1020             


Gln Val  Arg Lys 
    1025         


<210> 6515
<211> 188
<212> PRT
<213> Homo sapiens

<400> 6515
Met Thr Ala Pro Ser Cys Ala Phe Pro Val Gln Phe Arg Gln Pro Ser 
1               5                   10                  15      


Val Ser Gly Leu Ser Gln Ile Thr Lys Ser Leu Tyr Ile Ser Asn Gly 
            20                  25                  30          


Val Ala Ala Asn Asn Lys Leu Met Leu Ser Ser Asn Gln Ile Thr Met 
        35                  40                  45              


Val Ile Asn Val Ser Val Glu Val Val Asn Thr Leu Tyr Glu Asp Ile 
    50                  55                  60                  


Gln Tyr Met Gln Val Pro Val Ala Asp Ser Pro Asn Ser Arg Leu Cys 
65                  70                  75                  80  


Asp Phe Phe Asp Pro Ile Ala Asp His Ile His Ser Val Glu Met Lys 
                85                  90                  95      


Gln Gly Arg Thr Leu Leu His Cys Ala Ala Gly Val Ser Arg Ser Ala 
            100                 105                 110         


Ala Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ala Met Ser Leu Leu 
        115                 120                 125             


Asp Ala His Thr Trp Thr Lys Ser Cys Arg Pro Ile Ile Arg Pro Asn 
    130                 135                 140                 


Ser Gly Phe Trp Glu Gln Leu Ile His Tyr Glu Phe Gln Leu Phe Gly 
145                 150                 155                 160 


Lys Asn Thr Val His Met Val Ser Ser Pro Val Gly Met Ile Pro Asp 
                165                 170                 175     


Ile Tyr Glu Lys Glu Val Arg Leu Met Ile Pro Leu 
            180                 185             


<210> 6516
<211> 126
<212> PRT
<213> Homo sapiens

<400> 6516
Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Ala Glu Ser Arg Ser Val Ala Gln Ala Lys Val Gln Trp Cys Asp Leu 
                85                  90                  95      


Ser Pro Leu Gln Pro Leu Leu Pro Gly Phe Lys Arg Phe Ser Cys Leu 
            100                 105                 110         


Ser Leu Pro Asn Gly Met Gln Phe Leu Leu Val Ser Leu Ile 
        115                 120                 125     


<210> 6517
<211> 179
<212> PRT
<213> Homo sapiens

<400> 6517
Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Met Val Cys Asn Ser Cys Trp Leu Ala Ser Ser Glu Asn Val Thr Pro 
                85                  90                  95      


Gly Tyr Ile Glu His His Cys Ala Cys Ala Ser Pro His Pro Arg Cys 
            100                 105                 110         


Leu Val Ser Asn Val Pro Pro Val Ser Gly Ala Leu Met His Cys Phe 
        115                 120                 125             


Trp Ala Cys Leu Thr Thr Ala Ala Phe Phe Gly Pro Gln Ser Phe Thr 
    130                 135                 140                 


Thr Cys His Met Ser Phe Leu Val Ser Arg Asp Ile Leu Phe Tyr Ile 
145                 150                 155                 160 


Tyr Gly Phe Met Pro Phe Ile Ser Val Val Ile Trp Arg Phe Lys Lys 
                165                 170                 175     


Glu Arg Trp 
            


<210> 6518
<211> 179
<212> PRT
<213> Homo sapiens

<400> 6518
Met Gly Leu Ile Phe Ala Lys Leu Trp Ser Leu Phe Cys Asn Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Leu Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Val Lys Asn Thr His Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asn Thr Glu Phe Ile Ile Leu Val Val Asp Ser Ile Asp Arg 
                85                  90                  95      


Glu Arg Leu Ala Ile Thr Lys Glu Glu Leu Tyr Arg Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Ala Val Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Met Lys Gly Cys Met Thr Ala Ala Glu Ile Ser Lys Tyr Leu Thr Leu 
    130                 135                 140                 


Ser Ser Ile Lys Asp His Pro Trp His Ile Gln Ser Cys Cys Ala Leu 
145                 150                 155                 160 


Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Thr Ser Arg Ile 
                165                 170                 175     


Gly Val Arg 
            


<210> 6519
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 6519
Met Ser Gln Thr Gln Asp Tyr Glu Cys Arg Ser His Asn Val Asp Leu 
1               5                   10                  15      


Pro Glu Ser Arg Ile Pro Gly Ser Asn Thr Arg Leu Glu Trp Val Glu 
            20                  25                  30          


Ile Ile Glu Pro Arg Thr Arg Glu Arg Met Tyr Ala Asn Leu Val Thr 
        35                  40                  45              


Gly Glu Cys Val Trp Asp Pro Pro Ala Gly Val Arg Ile Lys Arg Thr 
    50                  55                  60                  


Ser Glu Asn Gln Trp Trp Glu Leu Phe Asp Pro Asn Thr Ser Arg Phe 
65                  70                  75                  80  


Tyr Tyr Tyr Asn Ala Ser Thr Gln Arg Thr Val Trp His Arg Pro Gln 
                85                  90                  95      


Gly Cys Asp Ile Ile Pro Leu Ala Lys Leu Gln Thr Leu Lys Gln Asn 
            100                 105                 110         


Thr Glu Ser Pro Arg Ala Ser Ala Glu Ser Ser Pro Gly Arg Gly Ser 
        115                 120                 125             


Ser Val Ser Arg Glu Gly Ser Thr Ser Ser Ser Leu Glu Pro Glu Pro 
    130                 135                 140                 


Asp Thr Glu Lys Ala Gln Glu Leu Pro Ala Arg Ala Gly Arg Pro Ala 
145                 150                 155                 160 


Ala Phe Gly Thr Val Lys Glu Asp Ser Gly Ser Ser Ser Pro Pro Gly 
                165                 170                 175     


Val Phe Leu Glu Lys Asp Tyr Glu Ile Tyr Arg Asp Tyr Ser Ala Asp 
            180                 185                 190         


Gly Gln Leu Leu His Tyr Arg Thr Ser Ser Leu Arg Trp Asn Ser Gly 
        195                 200                 205             


Ala Lys Glu Arg Met Leu Ile Lys Val Ala Asp Arg Glu Pro Ser Phe 
    210                 215                 220                 


Leu Ala Ala Gln Gly Asn Gly Tyr Ala Pro Asp Gly Pro Pro Gly Val 
225                 230                 235                 240 


Arg Ser Arg Arg Pro Ser Gly Ser Gln His Ser Pro Ser Leu Gln Thr 
                245                 250                 255     


Phe Ala Pro Glu Ala Asp Gly Thr Ile Phe Phe Pro Glu Arg Arg Pro 
            260                 265                 270         


Ser Pro Phe Leu Lys Arg Ala Glu Leu Pro Gly Ser Ser Ser Pro Leu 
        275                 280                 285             


Leu Ala Gln Pro Arg Lys Pro Ser Gly Asp Ser Gln Pro Ser Ser Pro 
    290                 295                 300                 


Arg Tyr Gly Tyr Glu Pro Pro Leu Tyr Glu Glu Pro Pro Val Glu Tyr 
305                 310                 315                 320 


Gln Ala Pro Ile Tyr Asp Glu Pro Pro Met Asp Val Gln Phe Glu Ala 
                325                 330                 335     


Gly Gly Gly Tyr Gln Ala Gly Ser Pro Gln Arg Ser Pro Gly Arg Lys 
            340                 345                 350         


Pro Arg Pro Phe Leu Gln Pro Asn Lys Gln Gly Pro Pro Ser Pro Cys 
        355                 360                 365             


Gln Gln Leu Val Leu Thr Lys Gln Lys Cys Pro Glu Arg Phe Leu Ser 
    370                 375                 380                 


Leu Glu Tyr Ser Pro Ala Gly Lys Glu Tyr Val Arg Gln Leu Val Tyr 
385                 390                 395                 400 


Val Glu Gln Ala Gly Ser Ser Pro Lys Leu Arg Ala Gly Pro Arg His 
                405                 410                 415     


Lys Tyr Ala Pro Asn Pro Gly Gly Gly Ser Tyr Ser Leu Gln Pro Ser 
            420                 425                 430         


Pro Cys Leu Leu Arg Asp Gln Arg Leu Gly Val Lys Ser Gly Asp Tyr 
        435                 440                 445             


Ser Thr Met Glu Gly Pro Glu Leu Arg His Ser Gln Pro Pro Thr Pro 
    450                 455                 460                 


Leu Pro Gln Ala Gln Glu Asp Ala Met Ser Trp Ser Ser Gln Gln Asp 
465                 470                 475                 480 


Thr Leu Ser Ser Thr Gly Tyr Ser Pro Gly Thr Arg Lys Arg Lys Ser 
                485                 490                 495     


Arg Lys Pro Ser Leu Cys Gln Ala Thr Ser Ala Thr Pro Thr Glu Gly 
            500                 505                 510         


Pro Gly Asp Leu Leu Val Glu Gln Pro Leu Ala Glu Glu Gln Pro Pro 
        515                 520                 525             


Cys Gly Thr Ser Leu Ala Pro Val Lys Arg Ala Glu Gly Glu Ala Glu 
    530                 535                 540                 


Gly Ala Arg Gly Ala Ala Glu Pro Phe Leu Ala Gln Ala Arg Leu Ala 
545                 550                 555                 560 


Trp Glu Ala Gln Gln Ala His Phe His Met Lys Gln Arg Ser Ser Trp 
                565                 570                 575     


Asp Ser Gln Gln Asp Gly Ser Gly Tyr Glu Ser Asp Gly Ala Leu Pro 
            580                 585                 590         


Leu Pro Met Pro Gly Pro Val Val Arg Ala Phe Ser Glu Asp Glu Ala 
        595                 600                 605             


Leu Ala Gln Gln Glu Asn Arg His Trp Arg Arg Gly Thr Phe Glu Lys 
    610                 615                 620                 


Leu Gly Phe Pro Gln Ile Leu Leu Glu Lys Ser Val Ser Val Gln Thr 
625                 630                 635                 640 


Asn Leu Ala Ser Pro Glu Pro Tyr Leu His Pro Ser Gln Ser Glu Asp 
                645                 650                 655     


Leu Ala Ala Cys Ala Gln Phe Glu Ser Ser Arg Gln Ser Arg Ser Gly 
            660                 665                 670         


Val Pro Ser Ser Ser Cys Val Phe Pro Thr Phe Thr Leu Arg Lys Pro 
        675                 680                 685             


Ser Ser Glu Thr Asp Ile Glu Asn Trp Ala Ser Lys His Phe Asn Lys 
    690                 695                 700                 


His Thr Gln Gly Leu Phe Arg Arg Lys Val Ser Ile Ala Asn Met Leu 
705                 710                 715                 720 


Ala Trp Ser Ser Glu Ser Ile Lys Lys Pro Met Ile Val Thr Ser Asp 
                725                 730                 735     


Arg His Val Lys Lys Glu Ala Cys Glu Leu Phe Lys Leu Ile Gln Met 
            740                 745                 750         


Tyr Met Gly Asp Arg Arg Ala Lys Ala Asp Pro Leu His Val Ala Leu 
        755                 760                 765             


Glu Val Ala Thr Lys Gly Trp Ser Val Gln Gly Leu Arg Asp Glu Leu 
    770                 775                 780                 


Tyr Ile Gln Leu Cys Arg Gln Thr Thr Glu Asn Phe Arg Leu Glu Ser 
785                 790                 795                 800 


Leu Ala Arg Gly Trp Glu Leu Met Ala Ile Cys Leu Ala Phe Phe Pro 
                805                 810                 815     


Pro Thr Pro Lys Phe His Ser Tyr Leu Glu Gly Tyr Ile Tyr Arg His 
            820                 825                 830         


Met Asp Pro Val Asn Asp Thr Lys Val Thr Gln His Ile Lys Glu Leu 
        835                 840                 845             


Leu Glu Arg Asn Thr Lys Lys Lys Ser Lys Leu Arg Lys Lys Pro Lys 
    850                 855                 860                 


Pro Tyr Val Glu Glu Pro Asp Gly Val Ala Ile Ser Thr Tyr Ala Lys 
865                 870                 875                 880 


Tyr Cys Tyr His Lys Leu Gln Lys Ala Ala Leu Thr Gly Ala Lys Lys 
                885                 890                 895     


Gly Leu Lys Lys Pro Asn Val Glu Glu Ile Arg His Ala Lys Asn Ala 
            900                 905                 910         


Val Phe Ser Pro Ser Met Phe Gly Ser Ala Leu Gln Glu Val Met Gly 
        915                 920                 925             


Met Gln Arg Glu Arg Tyr Pro Glu Arg Gln Leu Pro Trp Val Gln Thr 
    930                 935                 940                 


Arg Leu Ser Glu Glu Val Leu Ala Leu Asn Gly Asp Gln Thr Glu Gly 
945                 950                 955                 960 


Ile Phe Arg Val Pro Gly Asp Ile Asp Glu Val Asn Ala Leu Lys Leu 
                965                 970                 975     


Gln Val Asp Gln Trp Lys Val Pro Thr Gly Leu Glu Asp Pro His Val 
            980                 985                 990         


Pro Ala Ser Leu Leu Lys Leu Trp  Tyr Arg Glu Leu Glu  Glu Pro Leu 
        995                 1000                 1005             


Ile Pro  His Glu Phe Tyr Glu  Gln Cys Ile Ala His  Tyr Asp Ser 
    1010                 1015                 1020             


Pro Glu  Ala Ala Val Ala Val  Val His Ala Leu Pro  Arg Ile Asn 
    1025                 1030                 1035             


Arg Met  Val Leu Cys Tyr Leu  Ile Arg Phe Leu Gln  Val Phe Val 
    1040                 1045                 1050             


Gln Pro  Ala Asn Val Ala Val  Thr Lys Met Asp Val  Ser Asn Leu 
    1055                 1060                 1065             


Ala Met  Val Met Ala Pro Asn  Cys Leu Arg Cys Gln  Ser Asp Asp 
    1070                 1075                 1080             


Pro Arg  Val Ile Phe Glu Asn  Thr Arg Lys Glu Met  Ser Phe Leu 
    1085                 1090                 1095             


Arg Val  Leu Ile Gln His Leu  Asp Thr Ser Phe Met  Glu Gly Val 
    1100                 1105                 1110             


Leu 
    


<210> 6520
<211> 273
<212> PRT
<213> Homo sapiens

<400> 6520
Met Gly Gln Lys Val Thr Gly Gly Ile Lys Thr Val Asp Met Arg Asp 
1               5                   10                  15      


Pro Thr Tyr Arg Pro Leu Lys Gln Glu Leu Gln Gly Leu Asp Tyr Cys 
            20                  25                  30          


Lys Pro Thr Arg Leu Asp Leu Leu Leu Asp Met Pro Pro Val Ser Tyr 
        35                  40                  45              


Asp Val Gln Leu Leu His Ser Trp Asn Asn Asn Asp Arg Ser Leu Asn 
    50                  55                  60                  


Val Phe Val Lys Glu Asp Asp Lys Leu Ile Phe His Arg His Pro Val 
65                  70                  75                  80  


Ala Gln Ser Thr Asp Ala Ile Arg Gly Lys Val Gly Tyr Thr Arg Gly 
                85                  90                  95      


Leu His Val Trp Gln Ile Thr Trp Ala Met Arg Gln Arg Gly Thr His 
            100                 105                 110         


Ala Val Val Gly Val Ala Thr Ala Asp Ala Pro Leu His Ser Val Gly 
        115                 120                 125             


Tyr Thr Thr Leu Val Gly Asn Asn His Glu Ser Trp Gly Trp Asp Leu 
    130                 135                 140                 


Gly Arg Asn Arg Leu Tyr His Asp Gly Lys Asn Gln Pro Ser Lys Thr 
145                 150                 155                 160 


Tyr Pro Ala Phe Leu Glu Pro Asp Glu Thr Phe Ile Val Pro Asp Ser 
                165                 170                 175     


Phe Leu Val Ala Leu Asp Met Asp Asp Gly Thr Leu Ser Phe Ile Val 
            180                 185                 190         


Asp Gly Gln Tyr Met Gly Val Ala Phe Arg Gly Leu Lys Gly Lys Lys 
        195                 200                 205             


Leu Tyr Pro Val Val Ser Ala Val Trp Gly His Cys Glu Ile Arg Met 
    210                 215                 220                 


Arg Tyr Leu Asn Gly Leu Asp Pro Glu Pro Leu Pro Leu Met Asp Leu 
225                 230                 235                 240 


Cys Arg Arg Ser Val Arg Leu Ala Leu Gly Arg Glu Arg Leu Gly Glu 
                245                 250                 255     


Ile His Thr Leu Pro Leu Pro Ala Ser Leu Lys Ala Tyr Leu Leu Tyr 
            260                 265                 270         


Gln 
    


<210> 6521
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 6521
Met Pro Arg Gly Glu Ala Pro Gly Pro Gly Arg Arg Gly Ala Lys Asp 
1               5                   10                  15      


Glu Ala Leu Gly Glu Glu Ser Gly Glu Arg Trp Ser Pro Glu Phe His 
            20                  25                  30          


Leu Gln Arg Lys Leu Ala Asp Ser Ser His Ser Glu Gln Gln Asp Arg 
        35                  40                  45              


Asn Arg Val Ser Glu Glu Leu Ile Met Val Val Gln Glu Met Lys Lys 
    50                  55                  60                  


Tyr Phe Pro Ser Glu Arg Arg Asn Lys Pro Ser Thr Leu Asp Ala Leu 
65                  70                  75                  80  


Asn Tyr Ala Leu Arg Cys Val His Ser Val Gln Ala Asn Ser Glu Phe 
                85                  90                  95      


Phe Gln Ile Leu Ser Gln Asn Gly Ala Pro Gln Ala Asp Val Ser Met 
            100                 105                 110         


Tyr Ser Leu Glu Glu Leu Ala Thr Ile Ala Ser Glu His Thr Ser Lys 
        115                 120                 125             


Asn Thr Asp Thr Phe Val Ala Val Phe Ser Phe Leu Ser Gly Arg Leu 
    130                 135                 140                 


Val His Ile Ser Glu Gln Ala Ala Leu Ile Leu Asn Arg Lys Lys Asp 
145                 150                 155                 160 


Val Leu Ala Ser Ser His Phe Val Asp Leu Leu Ala Pro Gln Asp Met 
                165                 170                 175     


Arg Val Phe Tyr Ala His Thr Ala Arg Ala Gln Leu Pro Phe Trp Asn 
            180                 185                 190         


Asn Trp Thr Gln Arg Ala Ala Ala Arg Tyr Glu Cys Ala Pro Val Lys 
        195                 200                 205             


Pro Phe Phe Cys Arg Ile Arg Gly Gly Glu Asp Arg Lys Gln Glu Lys 
    210                 215                 220                 


Cys His Ser Pro Phe Arg Ile Ile Pro Tyr Leu Ile His Val His His 
225                 230                 235                 240 


Pro Ala Gln Pro Glu Leu Glu Ser Glu Pro Cys Cys Leu Thr Val Val 
                245                 250                 255     


Glu Lys Ile His Ser Gly Tyr Glu Ala Pro Arg Ile Pro Val Asn Lys 
            260                 265                 270         


Arg Ile Phe Thr Thr Thr His Thr Pro Gly Cys Val Phe Leu Glu Val 
        275                 280                 285             


Asp Glu Lys Ala Val Pro Leu Leu Gly Tyr Leu Pro Gln Asp Leu Ile 
    290                 295                 300                 


Gly Thr Ser Ile Leu Ser Tyr Leu His Pro Glu Asp Arg Ser Leu Met 
305                 310                 315                 320 


Val Ala Ile His Gln Lys Val Leu Lys Tyr Ala Gly His Pro Pro Phe 
                325                 330                 335     


Glu His Ser Pro Ile Arg Phe Cys Thr Gln Asn Gly Asp Tyr Ile Ile 
            340                 345                 350         


Leu Asp Ser Ser Trp Ser Ser Phe Val Asn Pro Trp Ser Arg Lys Ile 
        355                 360                 365             


Ser Phe Ile Ile Gly Arg His Lys Val Arg Thr Ser Pro Leu Asn Glu 
    370                 375                 380                 


Asp Val Phe Ala Thr Lys Ile Lys Lys Met Asn Asp Asn Asp Lys Asp 
385                 390                 395                 400 


Ile Thr Glu Leu Gln Glu Gln Ile Tyr Lys Leu Leu Leu Gln Pro Val 
                405                 410                 415     


His Val Ser Val Ser Ser Gly Tyr Gly Ser Leu Gly Ser Ser Gly Ser 
            420                 425                 430         


Gln Glu Gln Leu Val Ser Ile Ala Ser Ser Ser Glu Ala Ser Gly His 
        435                 440                 445             


Arg Val Glu Glu Thr Lys Ala Glu Gln Met Thr Leu Gln Gln Val Tyr 
    450                 455                 460                 


Ala Ser Val Asn Lys Ile Lys Asn Leu Gly Gln Gln Leu Tyr Ile Glu 
465                 470                 475                 480 


Ser Met Thr Lys Ser Ser Phe Lys Pro Val Thr Gly Thr Arg Thr Glu 
                485                 490                 495     


Pro Asn Gly Gly Gly Glu Ser Ala Asn Gly Gly Gly Glu Cys Lys Thr 
            500                 505                 510         


Phe Thr Ser Phe His Gln Thr Leu Lys Asn Asn Ser Val Tyr Thr Glu 
        515                 520                 525             


Pro Cys Glu Asp Leu Arg Asn Asp Glu His Ser Pro Ser Tyr Gln Gln 
    530                 535                 540                 


Ile Asn Cys Ile Asp Ser Val Ile Arg Tyr Leu Lys Ser Tyr Asn Ile 
545                 550                 555                 560 


Pro Ala Leu Lys Arg Lys Cys Ile Ser Cys Thr Asn Thr Thr Ser Ser 
                565                 570                 575     


Ser Ser Glu Glu Asp Lys Gln Asn His Lys Ala Asp Asp Val Gln Ala 
            580                 585                 590         


Leu Gln Ala Gly Leu Gln Ile Pro Ala Ile Pro Lys Ser Glu Met Pro 
        595                 600                 605             


Thr Asn Gly Arg Ser Ile Asp Thr Gly Gly Gly Ala Pro Gln Ile Leu 
    610                 615                 620                 


Ser Thr Ala Met Leu Ser Leu Gly Ser Gly Ile Ser Gln Cys Gly Tyr 
625                 630                 635                 640 


Ser Ser Thr Ile Val His Val Pro Pro Pro Glu Thr Ala Arg Asp Ala 
                645                 650                 655     


Thr Leu Phe Cys Glu Pro Trp Thr Leu Asn Met Gln Pro Ala Pro Leu 
            660                 665                 670         


Thr Ser Glu Glu Phe Lys His Val Gly Leu Thr Ala Ala Val Leu Ser 
        675                 680                 685             


Ala His Thr Gln Lys Glu Glu Gln Asn Tyr Val Asp Lys Phe Arg Glu 
    690                 695                 700                 


Lys Ile Leu Ser Ser Pro Tyr Ser Ser Tyr Leu Gln Gln Glu Ser Arg 
705                 710                 715                 720 


Ser Lys Ala Lys Tyr Ser Tyr Phe Gln Gly Asp Ser Thr Ser Lys Gln 
                725                 730                 735     


Thr Arg Ser Ala Gly Cys Arg Lys Gly Lys His Lys Arg Lys Lys Leu 
            740                 745                 750         


Pro Glu Pro Pro Asp Ser Ser Ser Ser Asn Thr Gly Ser Gly Pro Arg 
        755                 760                 765             


Arg Gly Ala His Gln Asn Ala Gln Pro Cys Cys Pro Ser Ala Ala Ser 
    770                 775                 780                 


Ser Pro His Thr Ser Ser Pro Thr Phe Pro Pro Ala Ala Met Val Pro 
785                 790                 795                 800 


Ser Gln Ala Pro Tyr Leu Val Pro Ala Phe Pro Leu Pro Ala Ala Thr 
                805                 810                 815     


Ser Pro Gly Arg Glu Tyr Ala Ala Pro Gly Thr Ala Pro Glu Gly Leu 
            820                 825                 830         


His Gly Leu Pro Leu Ser Glu Gly Leu Gln Pro Tyr Pro Ala Phe Pro 
        835                 840                 845             


Phe Pro Tyr Leu Asp Thr Phe Met Thr Val Phe Leu Pro Asp Pro Pro 
    850                 855                 860                 


Val Cys Pro Leu Leu Ser Pro Ser Phe Leu Pro Cys Pro Phe Leu Gly 
865                 870                 875                 880 


Ala Thr Ala Ser Ser Ala Ile Ser Pro Ser Met Ser Ser Ala Met Ser 
                885                 890                 895     


Pro Thr Leu Asp Pro Pro Pro Ser Val Thr Ser Gln Arg Arg Glu Glu 
            900                 905                 910         


Glu Lys Trp Glu Ala Gln Ser Glu Gly His Pro Phe Ile Thr Ser Arg 
        915                 920                 925             


Ser Ser Ser Pro Leu Gln Leu Asn Leu Leu Gln Glu Glu Met Pro Arg 
    930                 935                 940                 


Pro Ser Glu Ser Pro Asp Gln Met Arg Arg Asn Thr Cys Pro Gln Thr 
945                 950                 955                 960 


Glu Tyr Gln Cys Val Thr Gly Asn Asn Gly Ser Glu Ser Ser Pro Ala 
                965                 970                 975     


Thr Thr Gly Ala Leu Ser Thr Gly Ser Pro Pro Arg Glu Asn Pro Ser 
            980                 985                 990         


His Pro Thr Ala Ser Ala Leu Ser  Thr Gly Ser Pro Pro  Met Lys Asn 
        995                 1000                 1005             


Pro Ser  His Pro Thr Ala Ser  Ala Leu Ser Thr Gly  Ser Pro Pro 
    1010                 1015                 1020             


Met Lys  Asn Pro Ser His Pro  Thr Ala Ser Thr Leu  Ser Met Gly 
    1025                 1030                 1035             


Leu Pro  Pro Ser Arg Thr Pro  Ser His Pro Thr Ala  Thr Val Leu 
    1040                 1045                 1050             


Ser Thr  Gly Ser Pro Pro Ser  Glu Ser Pro Ser Arg  Thr Gly Ser 
    1055                 1060                 1065             


Ala Ala  Ser Gly Ser Ser Asp  Ser Ser Ile Tyr Leu  Thr Ser Ser 
    1070                 1075                 1080             


Val Tyr  Ser Ser Lys Ile Ser  Gln Asn Gly Gln Gln  Ser Gln Asp 
    1085                 1090                 1095             


Val Gln  Lys Lys Glu Thr Phe  Pro Asn Val Ala Glu  Glu Pro Ile 
    1100                 1105                 1110             


Trp Arg  Met Ile Arg Gln Thr  Pro Glu Arg Ile Leu  Met Thr Tyr 
    1115                 1120                 1125             


Gln Val  Pro Glu Arg Val Lys  Glu Val Val Leu Lys  Glu Asp Leu 
    1130                 1135                 1140             


Glu Lys  Leu Glu Ser Met Arg  Gln Gln Gln Pro Gln  Phe Ser His 
    1145                 1150                 1155             


Gly Gln  Lys Glu Glu Leu Ala  Lys Val Tyr Asn Trp  Ile Gln Ser 
    1160                 1165                 1170             


Gln Thr  Val Thr Gln Glu Ile  Asp Ile Gln Ala Cys  Val Thr Cys 
    1175                 1180                 1185             


Glu Asn  Glu Asp Ser Ala Asp  Gly Ala Ala Thr Ser  Cys Gly Gln 
    1190                 1195                 1200             


Val Leu  Val Glu Asp Ser Cys  
    1205                 1210 


<210> 6522
<211> 378
<212> PRT
<213> Homo sapiens

<400> 6522
Met Pro Arg Gly Glu Ala Pro Gly Pro Gly Arg Arg Gly Ala Lys Asp 
1               5                   10                  15      


Glu Ala Leu Gly Glu Glu Ser Gly Glu Arg Trp Ser Pro Glu Phe His 
            20                  25                  30          


Leu Gln Arg Lys Leu Ala Asp Ser Ser His Ser Glu Gln Gln Asp Arg 
        35                  40                  45              


Asn Arg Val Ser Glu Glu Leu Ile Met Val Val Gln Glu Met Lys Lys 
    50                  55                  60                  


Tyr Phe Pro Ser Glu Arg Arg Asn Lys Pro Ser Thr Leu Asp Ala Leu 
65                  70                  75                  80  


Asn Tyr Ala Leu Arg Cys Val His Ser Val Gln Ala Asn Ser Glu Phe 
                85                  90                  95      


Phe Gln Ile Leu Ser Gln Asn Gly Ala Pro Gln Ala Asp Val Ser Met 
            100                 105                 110         


Tyr Ser Leu Glu Glu Leu Ala Thr Ile Ala Ser Glu His Thr Ser Lys 
        115                 120                 125             


Asn Thr Asp Thr Phe Val Ala Val Phe Ser Phe Leu Ser Gly Arg Leu 
    130                 135                 140                 


Val His Ile Ser Glu Gln Ala Ala Leu Ile Leu Asn Arg Lys Lys Asp 
145                 150                 155                 160 


Val Leu Ala Ser Ser His Phe Val Asp Leu Leu Ala Pro Gln Asp Met 
                165                 170                 175     


Arg Val Phe Tyr Ala His Thr Ala Arg Ala Gln Leu Pro Phe Trp Asn 
            180                 185                 190         


Asn Trp Thr Gln Arg Ala Ala Arg Tyr Glu Cys Ala Pro Val Lys Pro 
        195                 200                 205             


Phe Phe Cys Arg Ile Arg Gly Gly Glu Asp Arg Lys Gln Glu Lys Cys 
    210                 215                 220                 


His Ser Pro Phe Arg Ile Ile Pro Tyr Leu Ile His Val His His Pro 
225                 230                 235                 240 


Ala Gln Pro Glu Leu Glu Ser Glu Pro Cys Cys Leu Thr Val Val Glu 
                245                 250                 255     


Lys Ile His Ser Gly Tyr Glu Ala Pro Arg Ile Pro Val Asn Lys Arg 
            260                 265                 270         


Ile Phe Thr Thr Thr His Thr Pro Gly Cys Val Phe Leu Glu Val Asp 
        275                 280                 285             


Glu Lys Ala Val Pro Leu Leu Gly Tyr Leu Pro Gln Asp Leu Ile Gly 
    290                 295                 300                 


Thr Ser Ile Leu Ser Tyr Leu His Pro Glu Asp Arg Ser Leu Met Val 
305                 310                 315                 320 


Ala Ile His Gln Lys Val Leu Lys Tyr Ala Gly His Pro Pro Phe Glu 
                325                 330                 335     


His Ser Pro Ile Arg Phe Cys Thr Gln Asn Gly Asp Tyr Ile Ile Leu 
            340                 345                 350         


Asp Ser Ser Trp Ser Ser Phe Val Asn Pro Trp Ser Arg Lys Ile Ser 
        355                 360                 365             


Phe Ile Ile Gly Arg His Lys Val Arg Thr 
    370                 375             


<210> 6523
<211> 597
<212> PRT
<213> Homo sapiens

<400> 6523
Met Glu Arg Pro Ala Pro Leu Ala Val Leu Pro Phe Ser Asp Pro Ala 
1               5                   10                  15      


His Ala Leu Ser Leu Leu Arg Gly Leu Ser Gln Leu Arg Ala Glu Arg 
            20                  25                  30          


Lys Phe Leu Asp Val Thr Leu Glu Ala Ala Gly Gly Arg Asp Phe Pro 
        35                  40                  45              


Ala His Arg Ala Val Leu Ala Ala Ala Ser Pro Tyr Phe Arg Ala Met 
    50                  55                  60                  


Phe Ala Gly Gln Leu Arg Glu Ser Arg Ala Glu Arg Val Arg Leu His 
65                  70                  75                  80  


Gly Val Pro Pro Asp Met Leu Gln Leu Leu Leu Asp Phe Ser Tyr Thr 
                85                  90                  95      


Gly Arg Val Ala Val Ser Gly Asp Asn Ala Glu Pro Leu Leu Arg Ala 
            100                 105                 110         


Ala Asp Leu Leu Gln Phe Pro Ala Val Lys Glu Ala Cys Gly Ala Phe 
        115                 120                 125             


Leu Gln Gln Gln Leu Asp Leu Ala Asn Cys Leu Asp Met Gln Asp Phe 
    130                 135                 140                 


Ala Glu Ala Phe Ser Cys Ser Gly Leu Ala Ser Ala Ala Gln Arg Phe 
145                 150                 155                 160 


Ile Leu Arg His Val Gly Glu Leu Gly Ala Glu Gln Leu Glu Arg Leu 
                165                 170                 175     


Pro Leu Ala Arg Leu Leu Arg Tyr Leu Arg Asp Asp Gly Leu Cys Val 
            180                 185                 190         


Pro Lys Glu Glu Ala Ala Tyr Gln Leu Ala Leu Arg Trp Val Arg Ala 
        195                 200                 205             


Asp Pro Pro Arg Arg Ala Ala His Trp Pro Gln Leu Leu Glu Ala Val 
    210                 215                 220                 


Arg Leu Pro Phe Val Arg Arg Phe Tyr Leu Leu Ala His Val Glu Ala 
225                 230                 235                 240 


Glu Pro Leu Val Ala Arg Cys Pro Pro Cys Leu Arg Leu Leu Arg Glu 
                245                 250                 255     


Ala Arg Asp Phe Gln Ala Ala Arg Tyr Asp Arg His Asp Arg Gly Pro 
            260                 265                 270         


Cys Pro Arg Met Arg Pro Arg Pro Ser Thr Gly Leu Ala Glu Ile Leu 
        275                 280                 285             


Val Leu Val Gly Gly Cys Asp Gln Asp Cys Asp Glu Leu Val Thr Val 
    290                 295                 300                 


Asp Cys Tyr Asn Pro Gln Thr Gly Gln Trp Arg Tyr Leu Ala Glu Phe 
305                 310                 315                 320 


Pro Asp His Leu Gly Gly Gly Tyr Ser Ile Val Ala Leu Gly Asn Asp 
                325                 330                 335     


Ile Tyr Val Thr Gly Gly Ser Asp Gly Ser Arg Leu Tyr Asp Cys Val 
            340                 345                 350         


Trp Arg Tyr Asn Ser Ser Val Asn Glu Trp Ala Glu Val Ala Pro Met 
        355                 360                 365             


Leu Lys Ala Arg Glu Tyr His Ser Ser Ser Val Leu Asp Gly Leu Leu 
    370                 375                 380                 


Tyr Val Val Ala Ala Asp Ser Thr Glu Arg Tyr Asp His Thr Thr Asp 
385                 390                 395                 400 


Ser Trp Glu Ala Leu Gln Pro Met Thr Tyr Pro Met Asp Asn Cys Ser 
                405                 410                 415     


Thr Thr Ala Cys Arg Gly Arg Leu Tyr Ala Ile Gly Ser Leu Ala Gly 
            420                 425                 430         


Lys Glu Thr Met Val Met Gln Cys Tyr Asp Pro Asp Thr Asp Leu Trp 
        435                 440                 445             


Ser Leu Val Asp Cys Gly Gln Leu Pro Pro Trp Ser Phe Ala Pro Lys 
    450                 455                 460                 


Thr Ala Thr Leu Asn Gly Leu Met Tyr Phe Val Arg Asp Asp Ser Ala 
465                 470                 475                 480 


Glu Val Asp Val Tyr Asn Pro Thr Arg Asn Glu Trp Asp Lys Ile Pro 
                485                 490                 495     


Ser Met Asn Gln Val His Val Gly Gly Ser Leu Ala Val Leu Gly Gly 
            500                 505                 510         


Lys Leu Tyr Val Ser Gly Gly Tyr Asp Asn Thr Phe Glu Leu Ser Asp 
        515                 520                 525             


Val Val Glu Ala Tyr Asp Pro Glu Thr Arg Ala Trp Ser Val Val Gly 
    530                 535                 540                 


Arg Leu Pro Glu Pro Thr Phe Trp His Gly Ser Val Ser Ile Phe Arg 
545                 550                 555                 560 


Gln Phe Met Pro Gln Thr Phe Ser Gly Gly Arg Gly Phe Glu Leu Asp 
                565                 570                 575     


Ser Gly Ser Asp Asp Met Asp Pro Gly Arg Pro Arg Pro Pro Arg Asp 
            580                 585                 590         


Pro Asp Glu Leu His 
        595         


<210> 6524
<211> 539
<212> PRT
<213> Homo sapiens

<400> 6524
Met Glu Arg Pro Ala Pro Leu Ala Val Leu Pro Phe Ser Asp Pro Ala 
1               5                   10                  15      


His Ala Leu Ser Leu Leu Arg Gly Leu Ser Gln Leu Arg Ala Glu Arg 
            20                  25                  30          


Lys Phe Leu Asp Val Thr Leu Glu Ala Ala Gly Gly Arg Asp Phe Pro 
        35                  40                  45              


Ala His Arg Ala Val Leu Ala Ala Ala Ser Pro Tyr Phe Arg Ala Met 
    50                  55                  60                  


Phe Ala Gly Gln Leu Arg Glu Ser Arg Ala Glu Arg Val Arg Leu His 
65                  70                  75                  80  


Gly Val Pro Pro Asp Met Leu Gln Leu Leu Leu Asp Phe Ser Tyr Thr 
                85                  90                  95      


Gly Arg Val Ala Val Ser Gly Asp Asn Ala Glu Pro Leu Leu Arg Ala 
            100                 105                 110         


Ala Asp Leu Leu Gln Phe Pro Ala Val Lys Glu Ala Cys Gly Ala Phe 
        115                 120                 125             


Leu Gln Gln Gln Leu Asp Leu Ala Asn Cys Leu Asp Met Gln Asp Phe 
    130                 135                 140                 


Ala Glu Ala Phe Ser Cys Ser Gly Leu Ala Ser Ala Ala Gln Arg Phe 
145                 150                 155                 160 


Ile Leu Arg His Val Gly Glu Leu Gly Ala Glu Gln Leu Glu Arg Leu 
                165                 170                 175     


Pro Leu Ala Arg Leu Leu Arg Tyr Leu Arg Asp Asp Gly Leu Cys Val 
            180                 185                 190         


Pro Lys Glu Glu Ala Ala Tyr Gln Leu Ala Leu Arg Trp Val Arg Ala 
        195                 200                 205             


Asp Pro Pro Arg Arg Ala Ala His Trp Pro Gln Leu Leu Glu Ala Val 
    210                 215                 220                 


Arg Leu Pro Phe Val Arg Arg Phe Tyr Leu Leu Ala His Val Glu Ala 
225                 230                 235                 240 


Glu Pro Leu Val Ala Arg Cys Pro Pro Cys Leu Arg Leu Leu Arg Glu 
                245                 250                 255     


Ala Arg Asp Phe Gln Ala Ala Arg Tyr Asp Arg His Asp Arg Gly Pro 
            260                 265                 270         


Cys Pro Arg Met Arg Pro Arg Pro Ser Thr Gly Leu Ala Glu Ile Leu 
        275                 280                 285             


Val Leu Val Gly Gly Cys Asp Gln Asp Cys Asp Glu Leu Val Thr Val 
    290                 295                 300                 


Asp Cys Tyr Asn Pro Gln Thr Gly Gln Trp Arg Tyr Leu Ala Glu Phe 
305                 310                 315                 320 


Pro Asp His Leu Gly Gly Gly Tyr Ser Ile Val Ala Leu Gly Asn Asp 
                325                 330                 335     


Ile Tyr Val Thr Gly Gly Ser Asp Gly Ser Arg Leu Tyr Asp Cys Val 
            340                 345                 350         


Trp Arg Tyr Asn Ser Ser Val Asn Glu Trp Ala Glu Val Ala Pro Met 
        355                 360                 365             


Leu Lys Ala Arg Glu Tyr His Ser Ser Ser Val Leu Asp Gly Leu Leu 
    370                 375                 380                 


Tyr Val Val Ala Ala Asp Ser Thr Glu Arg Tyr Asp His Thr Thr Asp 
385                 390                 395                 400 


Ser Trp Glu Ala Leu Gln Pro Met Thr Tyr Pro Met Asp Asn Cys Ser 
                405                 410                 415     


Thr Thr Ala Cys Arg Gly Arg Leu Tyr Ala Ile Gly Ser Leu Ala Gly 
            420                 425                 430         


Lys Glu Thr Met Val Met Gln Cys Tyr Asp Pro Asp Thr Asp Leu Trp 
        435                 440                 445             


Ser Leu Val Asp Cys Gly Gln Leu Pro Pro Trp Ser Phe Ala Pro Lys 
    450                 455                 460                 


Thr Ala Thr Leu Asn Gly Leu Met Tyr Phe Val Arg Asp Asp Ser Ala 
465                 470                 475                 480 


Glu Val Asp Val Tyr Asn Pro Thr Arg Asn Glu Trp Asp Lys Ile Pro 
                485                 490                 495     


Ser Met Asn Gln Val Asn Phe Gln Ala Gly Gln His Trp Lys His Arg 
            500                 505                 510         


Leu Val Leu Ile Leu Gln Pro Lys Cys His Arg Asp Glu Cys Leu Gly 
        515                 520                 525             


Ser Thr Ala Met Met Gly Gly Ser His Leu Asn 
    530                 535                 


<210> 6525
<211> 688
<212> PRT
<213> Homo sapiens

<400> 6525
Met Asp Gly Ser Phe Val Gln His Ser Val Arg Val Leu Gln Glu Leu 
1               5                   10                  15      


Asn Lys Gln Arg Glu Lys Gly Gln Tyr Cys Asp Ala Thr Leu Asp Val 
            20                  25                  30          


Gly Gly Leu Val Phe Lys Ala His Trp Ser Val Leu Ala Cys Cys Ser 
        35                  40                  45              


His Phe Phe Gln Ser Leu Tyr Gly Asp Gly Ser Gly Gly Ser Val Val 
    50                  55                  60                  


Leu Pro Ala Gly Phe Ala Glu Ile Phe Gly Leu Leu Leu Asp Phe Phe 
65                  70                  75                  80  


Tyr Thr Gly His Leu Ala Leu Thr Ser Gly Asn Arg Asp Gln Val Leu 
                85                  90                  95      


Leu Ala Ala Arg Glu Leu Arg Val Pro Glu Ala Val Glu Leu Cys Gln 
            100                 105                 110         


Ser Phe Lys Pro Lys Thr Ser Val Gly Gln Ala Ala Gly Gly Gln Ser 
        115                 120                 125             


Gly Leu Gly Pro Pro Ala Ser Gln Asn Val Asn Ser His Val Lys Glu 
    130                 135                 140                 


Pro Ala Gly Leu Glu Glu Glu Glu Val Ser Arg Thr Leu Gly Leu Val 
145                 150                 155                 160 


Pro Arg Asp Gln Glu Pro Arg Gly Ser His Ser Pro Gln Arg Pro Gln 
                165                 170                 175     


Leu His Ser Pro Ala Gln Ser Glu Gly Pro Ser Ser Leu Cys Gly Lys 
            180                 185                 190         


Leu Lys Gln Ala Leu Lys Pro Cys Pro Leu Glu Asp Lys Lys Pro Glu 
        195                 200                 205             


Asp Cys Lys Val Pro Pro Arg Pro Leu Glu Ala Glu Gly Ala Gln Leu 
    210                 215                 220                 


Gln Gly Gly Ser Asn Glu Trp Glu Val Val Val Gln Val Glu Asp Asp 
225                 230                 235                 240 


Gly Asp Gly Asp Tyr Met Ser Glu Pro Glu Ala Val Leu Thr Arg Arg 
                245                 250                 255     


Lys Ser Asn Val Ile Arg Lys Pro Cys Ala Ala Glu Pro Ala Leu Ser 
            260                 265                 270         


Ala Gly Ser Leu Ala Ala Glu Pro Ala Glu Asn Arg Lys Gly Thr Ala 
        275                 280                 285             


Val Pro Val Glu Cys Pro Thr Cys His Lys Lys Phe Leu Ser Lys Tyr 
    290                 295                 300                 


Tyr Leu Lys Val His Asn Arg Lys His Thr Gly Glu Lys Pro Phe Glu 
305                 310                 315                 320 


Cys Pro Lys Cys Gly Lys Cys Tyr Phe Arg Lys Glu Asn Leu Leu Glu 
                325                 330                 335     


His Glu Ala Arg Asn Cys Met Asn Arg Ser Glu Gln Val Phe Thr Cys 
            340                 345                 350         


Ser Val Cys Gln Glu Thr Phe Arg Arg Arg Met Glu Leu Arg Val His 
        355                 360                 365             


Met Val Ser His Thr Gly Glu Met Pro Tyr Lys Cys Ser Ser Cys Ser 
    370                 375                 380                 


Gln Gln Phe Met Gln Lys Lys Asp Leu Gln Ser His Met Ile Lys Leu 
385                 390                 395                 400 


His Gly Ala Pro Lys Pro His Ala Cys Pro Thr Cys Ala Lys Cys Phe 
                405                 410                 415     


Leu Ser Arg Thr Glu Leu Gln Leu His Glu Ala Phe Lys His Arg Gly 
            420                 425                 430         


Glu Lys Leu Phe Val Cys Glu Glu Cys Gly His Arg Ala Ser Ser Arg 
        435                 440                 445             


Asn Gly Leu Gln Met His Ile Lys Ala Lys His Arg Asn Glu Arg Pro 
    450                 455                 460                 


His Val Cys Glu Phe Cys Ser His Ala Phe Thr Gln Lys Ala Asn Leu 
465                 470                 475                 480 


Asn Met His Leu Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys His 
                485                 490                 495     


Leu Cys Gly Lys Thr Phe Arg Thr Gln Ala Ser Leu Asp Lys His Asn 
            500                 505                 510         


Arg Thr His Thr Gly Glu Arg Pro Phe Ser Cys Glu Phe Cys Glu Gln 
        515                 520                 525             


Arg Phe Thr Glu Lys Gly Pro Leu Leu Arg His Val Ala Ser Arg His 
    530                 535                 540                 


Gln Glu Gly Arg Pro His Phe Cys Gln Ile Cys Gly Lys Thr Phe Lys 
545                 550                 555                 560 


Ala Val Glu Gln Leu Arg Val His Val Arg Arg His Lys Gly Val Arg 
                565                 570                 575     


Lys Phe Glu Cys Thr Glu Cys Gly Tyr Lys Phe Thr Arg Gln Ala His 
            580                 585                 590         


Leu Arg Arg His Met Glu Ile His Asp Arg Val Glu Asn Tyr Asn Pro 
        595                 600                 605             


Arg Gln Arg Lys Leu Arg Asn Leu Ile Ile Glu Asp Glu Lys Met Val 
    610                 615                 620                 


Val Val Ala Leu Gln Pro Pro Ala Glu Leu Glu Val Gly Ser Ala Glu 
625                 630                 635                 640 


Val Ile Val Glu Ser Leu Ala Gln Gly Gly Leu Ala Ser Gln Leu Pro 
                645                 650                 655     


Gly Gln Arg Leu Cys Ala Glu Glu Ser Phe Thr Gly Pro Gly Val Leu 
            660                 665                 670         


Glu Pro Ser Leu Ile Ile Thr Ala Ala Val Pro Glu Asp Cys Asp Thr 
        675                 680                 685             


<210> 6526
<211> 174
<212> PRT
<213> Homo sapiens

<400> 6526
Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys Arg Thr 
1               5                   10                  15      


Thr Cys Cys Arg Thr Thr Cys Trp Lys Pro Thr Thr Val Thr Thr Cys 
            20                  25                  30          


Ser Ser Thr Pro Cys Cys Gln Pro Ala Cys Cys Val Ser Ser Cys Cys 
        35                  40                  45              


Gln Pro Cys Cys Arg Pro Thr Cys Cys Gln Asn Thr Cys Cys Arg Thr 
    50                  55                  60                  


Thr Cys Cys Gln Pro Thr Cys Val Thr Ser Cys Cys Gln Pro Ser Cys 
65                  70                  75                  80  


Cys Ser Thr Pro Cys Cys Gln Pro Thr Cys Cys Gly Ser Ser Cys Cys 
                85                  90                  95      


Gly Gln Thr Ser Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser Cys Ala 
            100                 105                 110         


Pro Val Tyr Cys Arg Arg Thr Cys Tyr Tyr Pro Thr Thr Val Cys Leu 
        115                 120                 125             


Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Asn Cys Cys Gln Pro Cys 
    130                 135                 140                 


Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr Cys Phe 
145                 150                 155                 160 


Gln Pro Thr Cys Val Ser Ser Cys Cys Gln Pro Ser Cys Cys 
                165                 170                 


<210> 6527
<211> 198
<212> PRT
<213> Homo sapiens

<400> 6527
Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Ser 
1               5                   10                  15      


Gln Asp Leu Cys Gln Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr 
            20                  25                  30          


Thr Cys Cys Arg Thr Thr Cys Tyr Arg Pro Ser Cys Cys Val Ser Ser 
        35                  40                  45              


Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys 
    50                  55                  60                  


Cys Arg Pro Pro Arg Cys Cys Ile Ser Ser Cys Cys Arg Pro Ser Cys 
65                  70                  75                  80  


Cys Met Ser Ser Cys Cys Lys Pro Gln Cys Cys Gln Ser Val Cys Cys 
                85                  90                  95      


Gln Pro Thr Thr Thr Cys Cys His Pro Arg Cys Cys Ile Ser Ser Cys 
            100                 105                 110         


Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro Gln Cys Cys 
        115                 120                 125             


Gln Ser Val Cys Cys Gln Pro Asn Cys Cys Arg Pro Ser Cys Ser Ile 
    130                 135                 140                 


Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg Pro 
145                 150                 155                 160 


Cys Cys Cys Val Arg Pro Val Cys Gly Arg Val Ser Cys His Thr Thr 
                165                 170                 175     


Cys Tyr Arg Pro Thr Cys Val Ile Ser Ser Cys Pro Arg Pro Leu Cys 
            180                 185                 190         


Cys Ala Ser Ser Cys Cys 
        195             


<210> 6528
<211> 431
<212> PRT
<213> Homo sapiens

<400> 6528
Met Thr Ser Asp Cys Ser Ser Thr His Cys Ser Pro Glu Ser Cys Gly 
1               5                   10                  15      


Thr Ala Ser Gly Cys Ala Pro Ala Ser Ser Cys Ser Val Glu Thr Ala 
            20                  25                  30          


Cys Leu Pro Gly Thr Cys Ala Thr Ser Arg Cys Gln Thr Pro Ser Phe 
        35                  40                  45              


Leu Ser Arg Ser Arg Gly Leu Thr Gly Cys Leu Leu Pro Cys Tyr Phe 
    50                  55                  60                  


Thr Gly Ser Cys Asn Ser Pro Cys Leu Val Gly Asn Cys Ala Trp Cys 
65                  70                  75                  80  


Glu Asp Gly Val Phe Thr Ser Asn Glu Lys Glu Thr Met Gln Phe Leu 
                85                  90                  95      


Asn Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg Ser Leu Glu Glu 
            100                 105                 110         


Thr Asn Ala Glu Leu Glu Ser Arg Ile Gln Glu Gln Cys Glu Gln Asp 
        115                 120                 125             


Ile Pro Met Val Cys Pro Asp Tyr Gln Arg Tyr Phe Asn Thr Ile Glu 
    130                 135                 140                 


Asp Leu Gln Gln Lys Ile Leu Cys Thr Lys Ala Glu Asn Ser Arg Leu 
145                 150                 155                 160 


Ala Val Gln Leu Asp Asn Cys Lys Leu Ala Thr Asp Asp Phe Lys Ser 
                165                 170                 175     


Lys Tyr Glu Ser Glu Leu Ser Leu Arg Gln Leu Leu Glu Ala Asp Ile 
            180                 185                 190         


Ser Ser Leu His Gly Ile Leu Glu Glu Leu Thr Leu Cys Lys Ser Asp 
        195                 200                 205             


Leu Glu Ala His Val Glu Ser Leu Lys Glu Asp Leu Leu Cys Leu Lys 
    210                 215                 220                 


Lys Asn His Glu Glu Glu Val Asn Leu Leu Arg Glu Gln Leu Gly Asp 
225                 230                 235                 240 


Arg Leu Ser Val Glu Leu Asp Thr Ala Pro Thr Leu Asp Leu Asn Arg 
                245                 250                 255     


Val Leu Asp Glu Met Arg Cys Gln Cys Glu Thr Val Leu Ala Asn Asn 
            260                 265                 270         


Arg Arg Glu Ala Glu Glu Trp Leu Ala Val Gln Thr Glu Glu Leu Asn 
        275                 280                 285             


Gln Gln Gln Leu Ser Ser Ala Glu Gln Leu Gln Gly Cys Gln Met Glu 
    290                 295                 300                 


Ile Leu Glu Leu Lys Arg Thr Ala Ser Ala Leu Glu Ile Glu Leu Gln 
305                 310                 315                 320 


Ala Gln Gln Ser Leu Thr Glu Ser Leu Glu Cys Thr Val Ala Glu Thr 
                325                 330                 335     


Glu Ala Gln Tyr Ser Ser Gln Leu Ala Gln Ile Gln Cys Leu Ile Asp 
            340                 345                 350         


Asn Leu Glu Asn Gln Leu Ala Glu Ile Arg Cys Asp Leu Glu Arg Gln 
        355                 360                 365             


Asn Gln Glu Tyr Gln Val Leu Leu Asp Val Lys Ala Arg Leu Glu Gly 
    370                 375                 380                 


Glu Ile Asn Thr Tyr Trp Gly Leu Leu Asp Ser Glu Asp Ser Arg Leu 
385                 390                 395                 400 


Ser Cys Ser Pro Cys Ser Thr Thr Cys Thr Ser Ser Asn Thr Cys Glu 
                405                 410                 415     


Pro Cys Ser Ala Tyr Val Ile Cys Thr Val Glu Asn Cys Cys Leu 
            420                 425                 430     


<210> 6529
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6529
Met Ala Gly Ser Leu Pro Pro Cys Val Val Asp Cys Gly Thr Gly Tyr 
1               5                   10                  15      


Thr Lys Leu Gly Tyr Ala Gly Asn Thr Glu Pro Gln Phe Ile Ile Pro 
            20                  25                  30          


Ser Cys Ile Ala Ile Arg Glu Ser Ala Lys Val Val Asp Gln Ala Gln 
        35                  40                  45              


Arg Arg Val Leu Arg Gly Val Asp Asp Leu Asp Phe Phe Ile Gly Asp 
    50                  55                  60                  


Glu Ala Ile Asp Lys Pro Thr Tyr Ala Thr Lys Trp Pro Ile Arg His 
65                  70                  75                  80  


Gly Ile Ile Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gln Val 
                85                  90                  95      


Val Phe Lys Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Met 
            100                 105                 110         


Thr Glu Pro Pro Leu Asn Thr Pro Glu Asn Arg Glu Tyr Leu Ala Glu 
        115                 120                 125             


Ile Met Phe Glu Ser Phe Asn Val Pro Gly Leu Tyr Ile Ala Val Gln 
    130                 135                 140                 


Ala Val Leu Ala Leu Ala Ala Ser Trp Thr Ser Arg Gln Val Gly Glu 
145                 150                 155                 160 


Arg Thr Leu Thr Gly Ile Val Ile Asp Ser Gly Asp Gly Val Thr His 
                165                 170                 175     


Val Ile Pro Val Ala Glu Gly Tyr Val Ile Gly Ser Cys Ile Lys His 
            180                 185                 190         


Ile Pro Ile Ala Gly Arg Asp Ile Thr Tyr Phe Ile Gln Gln Leu Leu 
        195                 200                 205             


Arg Glu Arg Glu Val Gly Ile Pro Pro Glu Gln Ser Leu Glu Thr Ala 
    210                 215                 220                 


Lys Ala Ile Lys Glu Lys Tyr Cys Tyr Ile Cys Pro Asp Ile Val Lys 
225                 230                 235                 240 


Glu Phe Ala Lys Tyr Asp Val Asp Pro Arg Lys Trp Ile Lys Gln Tyr 
                245                 250                 255     


Thr Gly Ile Asn Ala Ile Asn Gln Lys Lys Phe Val Ile Asp Val Gly 
            260                 265                 270         


Tyr Glu Arg Phe Leu Gly Pro Glu Ile Phe Phe His Pro Glu Phe Ala 
        275                 280                 285             


Asn Pro Asp Phe Met Glu Ser Ile Ser Asp Val Val Asp Glu Val Ile 
    290                 295                 300                 


Gln Asn Cys Pro Ile Asp Val Arg Arg Pro Leu Tyr Lys Pro Glu Phe 
305                 310                 315                 320 


Phe Gln Val Cys His Thr Lys Lys Asp Tyr Glu Glu Tyr Gly Pro Ser 
                325                 330                 335     


Ile Cys Arg His Asn Pro Val Phe Gly Val Met Ser 
            340                 345             


<210> 6530
<211> 90
<212> PRT
<213> Homo sapiens

<400> 6530
Met Asp Asn Met Ser Pro Arg Leu Arg Ala Phe Leu Ser Glu Pro Ile 
1               5                   10                  15      


Gly Glu Lys Asp Val Cys Trp Val Asp Gly Ile Ser His Glu Leu Ala 
            20                  25                  30          


Ile Asn Leu Val Thr Lys Gly Ile Asn Lys Ala Tyr Ile Leu Leu Gly 
        35                  40                  45              


Gln Phe Leu Leu Met His Lys Asn Glu Ala Glu Phe Gln Arg Trp Leu 
    50                  55                  60                  


Ile Cys Cys Phe Gly Ala Thr Glu Cys Glu Ala Gln Gln Thr Ser His 
65                  70                  75                  80  


Cys Leu Lys Glu Trp Cys Ala Cys Phe Leu 
                85                  90  


<210> 6531
<211> 82
<212> PRT
<213> Homo sapiens

<400> 6531
Met Ala Ser Ser Ser Gly Ala Gly Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Asn Leu Asn Ala Val Arg Glu Thr Met Asp Val Leu Leu Glu Ile Ser 
            20                  25                  30          


Arg Ile Leu Asn Thr Gly Leu Asp Met Glu Thr Leu Ser Ile Cys Val 
        35                  40                  45              


Arg Leu Cys Glu Gln Gly Ile Asn Pro Glu Ala Leu Ser Ser Val Ile 
    50                  55                  60                  


Lys Glu Leu Arg Lys Ala Thr Glu Ala Leu Lys Ala Ala Glu Asn Met 
65                  70                  75                  80  


Thr Ser 
        


<210> 6532
<211> 1243
<212> PRT
<213> Homo sapiens

<400> 6532
Met Glu Thr Arg Ala Ala Glu Asn Thr Ala Ile Phe Met Cys Lys Cys 
1               5                   10                  15      


Cys Asn Leu Phe Ser Pro Asn Gln Ser Glu Leu Leu Ser His Val Ser 
            20                  25                  30          


Glu Lys His Met Glu Glu Gly Val Asn Val Asp Glu Ile Ile Ile Pro 
        35                  40                  45              


Leu Arg Pro Leu Ser Thr Pro Glu Pro Pro Asn Ser Ser Lys Thr Gly 
    50                  55                  60                  


Asp Glu Phe Leu Val Met Lys Arg Lys Arg Gly Arg Pro Lys Gly Ser 
65                  70                  75                  80  


Thr Lys Lys Ser Ser Thr Glu Glu Glu Leu Ala Glu Asn Ile Val Ser 
                85                  90                  95      


Pro Thr Glu Asp Ser Pro Leu Ala Pro Glu Glu Gly Asn Ser Leu Pro 
            100                 105                 110         


Pro Ser Ser Leu Glu Cys Ser Lys Cys Cys Arg Lys Phe Ser Asn Thr 
        115                 120                 125             


Arg Gln Leu Arg Lys His Ile Cys Ile Ile Val Leu Asn Leu Gly Glu 
    130                 135                 140                 


Glu Glu Gly Glu Ala Gly Asn Glu Ser Asp Leu Glu Leu Glu Lys Lys 
145                 150                 155                 160 


Cys Lys Glu Asp Asp Arg Glu Lys Ala Ser Lys Arg Pro Arg Ser Gln 
                165                 170                 175     


Lys Thr Glu Lys Val Gln Lys Ile Ser Gly Lys Glu Ala Arg Gln Leu 
            180                 185                 190         


Ser Gly Ala Lys Lys Pro Ile Ile Ser Val Val Leu Thr Ala His Glu 
        195                 200                 205             


Ala Ile Pro Gly Ala Thr Lys Ile Val Pro Val Glu Ala Gly Pro Pro 
    210                 215                 220                 


Glu Thr Gly Ala Thr Asn Ser Glu Thr Thr Ser Ala Asp Leu Val Pro 
225                 230                 235                 240 


Arg Arg Gly Tyr Gln Glu Tyr Ala Ile Gln Gln Thr Pro Tyr Glu Gln 
                245                 250                 255     


Pro Met Lys Ser Ser Arg Leu Gly Pro Thr Gln Leu Lys Ile Phe Thr 
            260                 265                 270         


Cys Glu Tyr Cys Asn Lys Val Phe Lys Phe Lys His Ser Leu Gln Ala 
        275                 280                 285             


His Leu Arg Ile His Thr Asn Glu Lys Pro Tyr Lys Cys Pro Gln Cys 
    290                 295                 300                 


Ser Tyr Ala Ser Ala Ile Lys Ala Asn Leu Asn Val His Leu Arg Lys 
305                 310                 315                 320 


His Thr Gly Glu Lys Phe Ala Cys Asp Tyr Cys Ser Phe Thr Cys Leu 
                325                 330                 335     


Ser Lys Gly His Leu Lys Val His Ile Glu Arg Val His Lys Lys Ile 
            340                 345                 350         


Lys Gln His Cys Arg Phe Cys Lys Lys Lys Tyr Ser Asp Val Lys Asn 
        355                 360                 365             


Leu Ile Lys His Ile Arg Asp Ala His Asp Pro Gln Asp Lys Lys Val 
    370                 375                 380                 


Lys Glu Ala Leu Asp Glu Leu Cys Leu Met Thr Arg Glu Gly Lys Arg 
385                 390                 395                 400 


Gln Leu Leu Tyr Asp Cys His Ile Cys Glu Arg Lys Phe Lys Asn Glu 
                405                 410                 415     


Leu Asp Arg Asp Arg His Met Leu Val His Gly Asp Lys Trp Pro Phe 
            420                 425                 430         


Ala Cys Glu Leu Cys Gly His Gly Ala Thr Lys Tyr Gln Ala Leu Glu 
        435                 440                 445             


Leu His Val Arg Lys His Pro Phe Val Tyr Val Cys Ala Val Cys Arg 
    450                 455                 460                 


Lys Lys Phe Val Ser Ser Ile Arg Leu Arg Thr His Ile Lys Glu Val 
465                 470                 475                 480 


His Gly Ala Ala Gln Glu Ala Leu Val Phe Thr Ser Ser Ile Asn Gln 
                485                 490                 495     


Ser Phe Cys Leu Leu Glu Pro Gly Gly Asp Ile Gln Gln Glu Ala Leu 
            500                 505                 510         


Gly Asp Gln Leu Gln Leu Val Glu Glu Glu Phe Ala Leu Gln Gly Val 
        515                 520                 525             


Asn Ala Leu Lys Glu Glu Ala Cys Pro Gly Asp Thr Gln Leu Glu Glu 
    530                 535                 540                 


Gly Arg Lys Glu Pro Glu Ala Pro Gly Glu Met Pro Ala Pro Ala Val 
545                 550                 555                 560 


His Leu Ala Ser Pro Gln Ala Glu Ser Thr Ala Leu Pro Pro Cys Glu 
                565                 570                 575     


Leu Glu Thr Thr Val Val Ser Ser Ser Asp Leu His Ser Gln Glu Val 
            580                 585                 590         


Val Ser Asp Asp Phe Leu Leu Lys Asn Asp Thr Ser Ser Ala Glu Ala 
        595                 600                 605             


His Ala Ala Pro Glu Lys Pro Pro Asp Met Gln His Arg Ser Ser Val 
    610                 615                 620                 


Gln Thr Gln Gly Glu Val Ile Thr Leu Leu Leu Ser Lys Ala Gln Ser 
625                 630                 635                 640 


Ala Gly Ser Asp Gln Glu Ser His Gly Ala Gln Ser Pro Leu Gly Glu 
                645                 650                 655     


Gly Gln Asn Met Ala Val Leu Ser Ala Gly Asp Pro Asp Pro Ser Arg 
            660                 665                 670         


Cys Leu Arg Ser Asn Pro Ala Glu Ala Ser Asp Leu Leu Pro Pro Val 
        675                 680                 685             


Ala Gly Gly Gly Asp Thr Ile Thr His Gln Pro Asp Ser Cys Lys Ala 
    690                 695                 700                 


Ala Pro Glu His Arg Ser Gly Ile Thr Ala Phe Met Lys Val Leu Asn 
705                 710                 715                 720 


Ser Leu Gln Lys Lys Gln Met Asn Thr Ser Leu Cys Glu Arg Ile Arg 
                725                 730                 735     


Lys Val Tyr Gly Asp Leu Glu Cys Glu Tyr Cys Gly Lys Leu Phe Trp 
            740                 745                 750         


Tyr Gln Val His Phe Asp Met His Val Arg Thr His Thr Arg Glu His 
        755                 760                 765             


Leu Tyr Tyr Cys Ser Gln Cys His Tyr Ser Ser Ile Thr Lys Asn Cys 
    770                 775                 780                 


Leu Lys Arg His Val Ile Gln Lys His Ser Asn Ile Leu Leu Lys Cys 
785                 790                 795                 800 


Pro Thr Asp Gly Cys Asp Tyr Ser Thr Pro Asp Lys Tyr Lys Leu Gln 
                805                 810                 815     


Ala His Leu Lys Val His Thr Ala Leu Asp Lys Arg Ser Tyr Ser Cys 
            820                 825                 830         


Pro Val Cys Glu Lys Ser Phe Ser Glu Asp Arg Leu Ile Lys Ser His 
        835                 840                 845             


Ile Lys Thr Asn His Pro Glu Val Ser Met Ser Thr Ile Ser Glu Val 
    850                 855                 860                 


Leu Gly Arg Arg Val Gln Leu Lys Gly Leu Ile Gly Lys Arg Ala Met 
865                 870                 875                 880 


Lys Cys Pro Tyr Cys Asp Phe Tyr Phe Met Lys Asn Gly Ser Asp Leu 
                885                 890                 895     


Gln Arg His Ile Trp Ala His Glu Gly Val Lys Pro Phe Lys Cys Ser 
            900                 905                 910         


Leu Cys Glu Tyr Ala Thr Arg Ser Lys Ser Asn Leu Lys Ala His Met 
        915                 920                 925             


Asn Arg His Ser Thr Glu Lys Thr His Leu Cys Asp Met Cys Gly Lys 
    930                 935                 940                 


Lys Phe Lys Ser Lys Gly Thr Leu Lys Ser His Lys Leu Leu His Thr 
945                 950                 955                 960 


Ala Asp Gly Lys Gln Phe Lys Cys Thr Val Cys Asp Tyr Thr Ala Ala 
                965                 970                 975     


Gln Lys Pro Gln Leu Leu Arg His Met Glu Gln His Val Ser Phe Lys 
            980                 985                 990         


Pro Phe Arg Cys Ala His Cys His  Tyr Ser Cys Asn Ile  Ser Gly Ser 
        995                 1000                 1005             


Leu Lys  Arg His Tyr Asn Arg  Lys His Pro Asn Glu  Glu Tyr Ala 
    1010                 1015                 1020             


Asn Val  Gly Thr Gly Glu Leu  Ala Ala Glu Val Leu  Ile Gln Gln 
    1025                 1030                 1035             


Gly Gly  Leu Lys Cys Pro Val  Cys Ser Phe Val Tyr  Gly Thr Lys 
    1040                 1045                 1050             


Trp Glu  Phe Asn Arg His Leu  Lys Asn Lys His Gly  Leu Lys Val 
    1055                 1060                 1065             


Val Glu  Ile Asp Gly Asp Pro  Lys Trp Glu Thr Ala  Thr Glu Ala 
    1070                 1075                 1080             


Pro Glu  Glu Pro Ser Thr Gln  Tyr Leu His Ile Thr  Glu Ala Glu 
    1085                 1090                 1095             


Glu Asp  Val Gln Gly Thr Gln  Ala Ala Val Ala Ala  Leu Gln Asp 
    1100                 1105                 1110             


Leu Arg  Tyr Thr Ser Glu Ser  Gly Asp Arg Leu Asp  Pro Thr Ala 
    1115                 1120                 1125             


Val Asn  Ile Leu Gln Gln Ile  Ile Glu Leu Gly Ala  Glu Thr His 
    1130                 1135                 1140             


Asp Ala  Thr Ala Leu Ala Ser  Val Val Ala Met Ala  Pro Gly Thr 
    1145                 1150                 1155             


Val Thr  Val Val Lys Gln Val  Thr Glu Glu Glu Pro  Ser Ser Asn 
    1160                 1165                 1170             


His Thr  Val Met Ile Gln Glu  Thr Val Gln Gln Ala  Ser Val Glu 
    1175                 1180                 1185             


Leu Ala  Glu Gln His His Leu  Val Val Ser Ser Asp  Asp Val Glu 
    1190                 1195                 1200             


Gly Ile  Glu Thr Val Thr Val  Tyr Thr Gln Gly Gly  Glu Ala Ser 
    1205                 1210                 1215             


Glu Phe  Ile Val Tyr Val Gln  Glu Ala Met Gln Pro  Val Glu Glu 
    1220                 1225                 1230             


Gln Ala  Val Glu Gln Pro Ala  Gln Glu Leu 
    1235                 1240             


<210> 6533
<211> 757
<212> PRT
<213> Homo sapiens

<400> 6533
Met Ala Leu Gly Glu Glu Lys Ala Glu Ala Glu Ala Ser Glu Asp Thr 
1               5                   10                  15      


Lys Ala Gln Ser Tyr Gly Arg Gly Ser Cys Arg Glu Arg Glu Leu Asp 
            20                  25                  30          


Ile Pro Gly Pro Met Ser Gly Glu Gln Pro Pro Arg Leu Glu Ala Glu 
        35                  40                  45              


Gly Gly Leu Ile Ser Pro Val Trp Gly Ala Glu Gly Ile Pro Ala Pro 
    50                  55                  60                  


Thr Cys Trp Ile Gly Thr Asp Pro Gly Gly Pro Ser Arg Ala His Gln 
65                  70                  75                  80  


Pro Gln Ala Ser Asp Ala Asn Arg Glu Pro Val Ala Glu Arg Ser Glu 
                85                  90                  95      


Pro Ala Leu Ser Gly Leu Pro Pro Ala Thr Met Gly Ser Gly Asp Leu 
            100                 105                 110         


Leu Leu Ser Gly Glu Ser Gln Val Glu Lys Thr Lys Leu Ser Ser Ser 
        115                 120                 125             


Glu Glu Phe Pro Gln Thr Leu Ser Leu Pro Arg Thr Thr Thr Ile Cys 
    130                 135                 140                 


Ser Gly His Asp Ala Asp Thr Glu Asp Asp Pro Ser Leu Ala Asp Leu 
145                 150                 155                 160 


Pro Gln Ala Leu Asp Leu Ser Gln Gln Pro His Ser Ser Gly Leu Ser 
                165                 170                 175     


Cys Leu Ser Gln Trp Lys Ser Val Leu Ser Pro Gly Ser Ala Ala Gln 
            180                 185                 190         


Pro Ser Ser Cys Ser Ile Ser Ala Ser Ser Thr Gly Ser Ser Leu Gln 
        195                 200                 205             


Gly His Gln Glu Arg Ala Glu Pro Arg Gly Gly Ser Leu Ala Lys Val 
    210                 215                 220                 


Ser Ser Ser Leu Glu Pro Val Val Pro Gln Glu Pro Ser Ser Val Val 
225                 230                 235                 240 


Gly Leu Gly Pro Arg Pro Gln Trp Ser Pro Gln Pro Val Phe Ser Gly 
                245                 250                 255     


Gly Asp Ala Ser Gly Leu Gly Arg Arg Arg Leu Ser Phe Gln Ala Glu 
            260                 265                 270         


Tyr Trp Ala Cys Val Leu Pro Asp Ser Leu Pro Pro Ser Pro Asp Arg 
        275                 280                 285             


His Ser Pro Leu Trp Asn Pro Asn Lys Glu Tyr Glu Asp Leu Leu Asp 
    290                 295                 300                 


Tyr Thr Tyr Pro Leu Arg Pro Gly Pro Gln Leu Pro Lys His Leu Asp 
305                 310                 315                 320 


Ser Arg Val Pro Ala Asp Pro Val Leu Gln Asp Ser Gly Val Asp Leu 
                325                 330                 335     


Asp Ser Phe Ser Val Ser Pro Ala Ser Thr Leu Lys Ser Pro Thr Asn 
            340                 345                 350         


Val Ser Pro Asn Cys Pro Pro Ala Glu Ala Thr Ala Leu Pro Phe Ser 
        355                 360                 365             


Gly Pro Arg Glu Pro Ser Leu Lys Gln Trp Pro Ser Arg Val Pro Gln 
    370                 375                 380                 


Lys Gln Gly Gly Met Gly Leu Ala Ser Trp Ser Gln Leu Ala Ser Thr 
385                 390                 395                 400 


Pro Arg Ala Pro Gly Ser Arg Asp Ala Arg Trp Glu Arg Arg Glu Pro 
                405                 410                 415     


Ala Leu Arg Gly Ala Lys Asp Arg Leu Thr Ile Gly Lys His Leu Asp 
            420                 425                 430         


Met Gly Ser Pro Gln Leu Arg Thr Arg Asp Arg Gly Trp Pro Ser Pro 
        435                 440                 445             


Arg Pro Glu Arg Glu Lys Arg Thr Ser Gln Ser Ala Arg Arg Pro Thr 
    450                 455                 460                 


Cys Thr Glu Ser Arg Trp Lys Ser Glu Glu Glu Val Glu Ser Asp Asp 
465                 470                 475                 480 


Glu Tyr Leu Ala Leu Pro Ala Arg Leu Thr Gln Val Ser Ser Leu Val 
                485                 490                 495     


Ser Tyr Leu Gly Ser Ile Ser Thr Leu Val Thr Leu Pro Thr Gly Asp 
            500                 505                 510         


Ile Lys Gly Gln Ser Pro Leu Glu Val Ser Asp Ser Asp Gly Pro Ala 
        515                 520                 525             


Ser Phe Pro Ser Ser Ser Ser Gln Ser Gln Leu Pro Pro Gly Ala Ala 
    530                 535                 540                 


Leu Gln Gly Ser Gly Asp Pro Glu Gly Gln Asn Pro Cys Phe Leu Arg 
545                 550                 555                 560 


Ser Phe Val Arg Ala His Asp Ser Ala Gly Glu Gly Ser Leu Gly Ser 
                565                 570                 575     


Ser Gln Ala Leu Gly Val Ser Ser Gly Leu Leu Lys Thr Arg Pro Ser 
            580                 585                 590         


Leu Pro Ala Arg Leu Asp Arg Trp Pro Phe Ser Asp Pro Asp Val Glu 
        595                 600                 605             


Gly Gln Leu Pro Arg Lys Gly Gly Glu Gln Gly Lys Glu Ser Leu Val 
    610                 615                 620                 


Gln Cys Val Lys Thr Phe Cys Cys Gln Leu Glu Glu Leu Ile Cys Trp 
625                 630                 635                 640 


Leu Tyr Asn Val Ala Asp Val Thr Asp His Gly Thr Ala Ala Arg Ser 
                645                 650                 655     


Asn Leu Thr Ser Leu Lys Ser Ser Leu Gln Leu Tyr Arg Gln Phe Lys 
            660                 665                 670         


Lys Asp Ile Asp Glu His Gln Ser Leu Thr Glu Ser Val Leu Gln Lys 
        675                 680                 685             


Gly Glu Ile Leu Leu Gln Cys Leu Leu Glu Asn Thr Pro Val Leu Glu 
    690                 695                 700                 


Asp Val Leu Gly Arg Ile Ala Lys Gln Ser Gly Glu Leu Glu Ser His 
705                 710                 715                 720 


Ala Asp Arg Leu Tyr Asp Ser Ile Leu Ala Ser Leu Asp Met Leu Ala 
                725                 730                 735     


Gly Cys Thr Leu Ile Pro Asp Lys Lys Pro Met Ala Ala Met Glu His 
            740                 745                 750         


Pro Cys Glu Gly Val 
        755         


<210> 6534
<211> 179
<212> PRT
<213> Homo sapiens

<400> 6534
Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 
65                  70                  75                  80  


Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 
                85                  90                  95      


Gln Tyr Trp Lys Glu Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu 
            100                 105                 110         


Ala Leu Lys Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp 
        115                 120                 125             


Asn Glu Ile Ala Arg Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val 
    130                 135                 140                 


Ala Glu His Val Gln Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly 
145                 150                 155                 160 


Glu Pro Leu Asp Asn Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser 
                165                 170                 175     


Glu Glu Glu 
            


<210> 6535
<211> 102
<212> PRT
<213> Homo sapiens

<400> 6535
Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 
65                  70                  75                  80  


Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 
                85                  90                  95      


Gln Tyr Trp Lys Glu Val 
            100         


<210> 6536
<211> 752
<212> PRT
<213> Homo sapiens

<400> 6536
Met Ala Glu Pro Ala Ser Val Thr Val Thr Phe Asp Asp Val Ala Leu 
1               5                   10                  15      


Tyr Phe Ser Glu Gln Glu Trp Glu Ile Leu Glu Lys Trp Gln Lys Gln 
            20                  25                  30          


Met Tyr Lys Gln Glu Met Lys Thr Asn Tyr Glu Thr Leu Asp Ser Leu 
        35                  40                  45              


Gly Tyr Ala Phe Ser Lys Pro Asp Leu Ile Thr Trp Met Glu Gln Gly 
    50                  55                  60                  


Arg Met Leu Leu Ile Ser Glu Gln Gly Cys Leu Asp Lys Thr Arg Arg 
65                  70                  75                  80  


Thr Thr Ser Pro Pro Thr Asp Glu Gln Leu Asn Met Lys Asn Thr Gly 
                85                  90                  95      


Lys Leu Leu Cys Phe Asp Asp Glu Gly Thr Pro Arg Thr Lys Glu Glu 
            100                 105                 110         


Asp Cys Arg Leu Asn Gly Pro Gln Lys Gln Asp Leu Cys Ala Ala Leu 
        115                 120                 125             


Arg Gly Lys Glu Arg Lys Ile Leu Leu Ala Gln Thr Ala Thr Phe Gln 
    130                 135                 140                 


Ser Pro Ser Leu Arg Glu Thr Glu Ile Leu Asn Lys Lys Val Ser Ile 
145                 150                 155                 160 


Thr Ala Tyr Asp Pro Asp Lys Lys Asp Leu Arg His Lys Pro Arg Glu 
                165                 170                 175     


Thr Pro Gly Arg Leu Glu Ile Pro Thr Gly Pro Arg Cys Tyr Ser Cys 
            180                 185                 190         


Tyr Val Cys Arg Lys Val Phe Gln Val Arg Arg Asp Leu Leu Lys His 
        195                 200                 205             


Lys Arg Ser His Ser Lys Ser Gln Leu Cys Arg Tyr Pro Lys Tyr Lys 
    210                 215                 220                 


Asn Ser Ser Arg Gly Lys Ser Glu Leu Arg Arg Thr Gln Arg Leu Leu 
225                 230                 235                 240 


Cys Gln Lys Lys Arg Phe Gln Cys Ser Glu Cys Glu Lys Ser Tyr Phe 
                245                 250                 255     


Leu Lys Gly Ser Leu Val Thr His Gln Val Val His Thr Gly Gln Arg 
            260                 265                 270         


Pro Tyr Pro Cys Pro Glu Cys Asp Lys Thr Phe Arg Tyr Arg Ala Asn 
        275                 280                 285             


Leu Lys Lys His Leu Cys Leu His Arg Gly Glu Arg Pro Phe Cys Cys 
    290                 295                 300                 


Gly Glu Cys Gly Arg Ala Phe Val Gln Gln Cys Glu Leu Thr Glu His 
305                 310                 315                 320 


Leu Arg Leu His Ser Gly Glu Lys Pro Phe Gln Cys Pro Gln Cys Asp 
                325                 330                 335     


Arg Cys Phe Arg Leu Lys Arg Gly Met Lys Val His Leu Thr Gln His 
            340                 345                 350         


Ser Gly Lys Arg Pro Phe His Cys Pro Glu Cys Gly Arg Ser Phe Ser 
        355                 360                 365             


Arg Lys Ala Ala Leu Lys Thr His Gln Arg Thr His Ser Glu Glu Lys 
    370                 375                 380                 


Pro Phe Ser Cys Gly Glu Cys Gly Arg Lys Phe Ile Tyr Lys Ile Lys 
385                 390                 395                 400 


Leu Asp Glu His Ile Arg Val His Thr Gly Glu Lys Pro Phe Ser Cys 
                405                 410                 415     


Pro Glu Cys Asn Lys Ser Phe Arg Leu Lys Arg Ser Leu Lys Ala His 
            420                 425                 430         


Gly Leu Gln His Ile Gly Lys Arg Pro Phe Gln Cys Pro Glu Cys Ser 
        435                 440                 445             


Arg Gly Phe Phe Trp Arg Asn Ala Met Arg Ala His Gln Arg Leu His 
    450                 455                 460                 


Ser Glu Gln Lys Pro Phe Pro Cys Ala Glu Cys Gly Lys Arg Phe Thr 
465                 470                 475                 480 


Arg Pro Ser Lys Leu Ala Cys His Thr Arg Val His Asp Arg Gln Lys 
                485                 490                 495     


Glu Phe Pro Cys Gly Glu Cys Lys Lys Thr Phe Ser Gln Gln Ser Arg 
            500                 505                 510         


Leu Thr Gln His Leu Lys Val His Thr Thr Glu Lys Pro Phe Ser Cys 
        515                 520                 525             


Ala Glu Cys Gly Arg Ser Phe Arg Arg Arg Ala His Leu Thr Glu His 
    530                 535                 540                 


Thr Arg Leu His Ser Gly Glu Glu Pro Phe Gln Cys Pro Glu Cys Asp 
545                 550                 555                 560 


Lys Ser Phe Ser Trp Lys Ala Ser Met Lys Phe His Gln Arg Met His 
                565                 570                 575     


Arg Asp Glu Lys Pro Phe Ala Cys Gly Glu Cys Asp Lys Thr Tyr Thr 
            580                 585                 590         


His Gln Ser Gln Leu Thr Glu His Leu Arg Leu His Ser Gly Glu Lys 
        595                 600                 605             


Pro Tyr Gln Cys Pro Glu Cys Glu Lys Thr Phe Arg Leu Lys Gly Asn 
    610                 615                 620                 


Leu Lys Ser His Leu Leu Gln His Ser Gly Gln Lys Pro Phe Ser Cys 
625                 630                 635                 640 


Val Met Cys Gly Lys Ser Phe Thr Gln Gln Tyr Arg Leu Thr Glu His 
                645                 650                 655     


Ile Arg Val His Ser Gly Glu Lys Pro Phe Gln Cys Pro Glu Cys Asp 
            660                 665                 670         


Lys Ser Tyr Cys Ile Arg Gly Ser Leu Lys Val His Leu Tyr Lys His 
        675                 680                 685             


Ser Gly Glu Arg Pro Phe Gln Cys Pro Glu Cys Gly Lys Gly Phe Leu 
    690                 695                 700                 


Gln Lys Arg Ser Leu Lys Ala His Leu Cys Leu His Ser Gly Glu Arg 
705                 710                 715                 720 


Pro Phe Ser Cys Asp Glu Cys Gly Arg Ser Phe Thr Tyr Val Gly Ala 
                725                 730                 735     


Leu Lys Thr His Ile Ala Val His Ala Lys Glu Lys Pro Ser Ser Leu 
            740                 745                 750         


<210> 6537
<211> 644
<212> PRT
<213> Homo sapiens

<400> 6537
Met Phe Leu Thr Tyr Met Glu Thr Val Thr Lys Glu Leu Val Ser Trp 
1               5                   10                  15      


Met Arg Gly His Glu Ser Ser Val Phe Ser Ile Ser Val His Ala Ser 
            20                  25                  30          


Gly Lys Tyr Ala Ile Thr Thr Ser Ser Asp Thr Ala Gln Leu Trp Asp 
        35                  40                  45              


Leu Asp Thr Phe Gln Arg Lys Arg Lys Leu Asn Ile Arg Gln Ser Val 
    50                  55                  60                  


Gly Ile Gln Lys Val Phe Phe Leu Pro Leu Ser Asn Thr Ile Leu Ser 
65                  70                  75                  80  


Cys Phe Lys Asp Asn Ser Ile Phe Ala Trp Glu Cys Asp Thr Leu Phe 
                85                  90                  95      


Cys Lys Tyr Gln Leu Pro Ala Pro Pro Glu Ser Ser Ser Ile Leu Tyr 
            100                 105                 110         


Lys Val Phe Ala Val Thr Arg Asp Gly Arg Ile Leu Ala Ala Gly Gly 
        115                 120                 125             


Lys Ser Asn His Leu His Leu Trp Cys Leu Glu Ala Arg Gln Leu Phe 
    130                 135                 140                 


Arg Ile Ile Gln Met Pro Thr Lys Val Arg Ala Ile Arg His Leu Glu 
145                 150                 155                 160 


Phe Leu Pro Asp Ser Phe Asp Ala Gly Ser Asn Gln Val Leu Gly Val 
                165                 170                 175     


Leu Ser Gln Asp Gly Ile Met Arg Phe Ile Asn Met Gln Thr Cys Lys 
            180                 185                 190         


Leu Leu Phe Glu Ile Gly Ser Leu Asp Glu Gly Ile Ser Ser Ser Ala 
        195                 200                 205             


Ile Ser Pro His Gly Arg Tyr Ile Ala Ser Ile Met Glu Asn Gly Ser 
    210                 215                 220                 


Leu Asn Ile Tyr Ser Val Gln Ala Leu Thr Gln Glu Ile Asn Lys Pro 
225                 230                 235                 240 


Pro Pro Pro Leu Val Lys Val Ile Glu Asp Leu Pro Lys Asn Lys Leu 
                245                 250                 255     


Ser Ser Ser Asp Leu Lys Met Lys Val Thr Ser Gly Arg Val Gln Gln 
            260                 265                 270         


Pro Ala Lys Ser Arg Glu Ser Lys Met Gln Thr Arg Ile Leu Lys Gln 
        275                 280                 285             


Asp Leu Thr Gly Asp Phe Glu Ser Lys Lys Asn Glu Leu Pro Asp Gly 
    290                 295                 300                 


Leu Asn Lys Lys Arg Leu Gln Ile Leu Leu Lys Gly Tyr Gly Glu Tyr 
305                 310                 315                 320 


Pro Thr Lys Tyr Arg Met Phe Ile Trp Arg Ser Leu Leu Gln Leu Pro 
                325                 330                 335     


Glu Asn His Thr Ala Phe Ser Thr Leu Ile Asp Lys Gly Thr His Val 
            340                 345                 350         


Ala Phe Leu Asn Leu Gln Lys Lys Tyr Pro Ile Lys Ser Arg Lys Leu 
        355                 360                 365             


Leu Arg Val Leu Gln Arg Thr Leu Ser Ala Leu Ala His Trp Ser Val 
    370                 375                 380                 


Ile Phe Ser Asp Thr Pro Tyr Leu Pro Leu Leu Ala Phe Pro Phe Val 
385                 390                 395                 400 


Lys Leu Phe Gln Asn Asn Gln Leu Ile Cys Phe Glu Val Ile Ala Thr 
                405                 410                 415     


Leu Ile Ile Asn Trp Cys Gln His Trp Phe Glu Tyr Phe Pro Asn Pro 
            420                 425                 430         


Pro Ile Asn Ile Leu Ser Met Ile Glu Asn Val Leu Ala Phe His Asp 
        435                 440                 445             


Lys Glu Leu Leu Gln His Phe Ile Asp His Asp Ile Thr Ser Gln Leu 
    450                 455                 460                 


Tyr Ala Trp Pro Leu Leu Glu Thr Val Phe Ser Glu Val Leu Thr Arg 
465                 470                 475                 480 


Glu Glu Trp Leu Lys Leu Phe Asp Asn Ile Phe Ser Asn His Pro Ser 
                485                 490                 495     


Phe Leu Leu Met Thr Val Val Ala Tyr Asn Ile Cys Ser Arg Thr Pro 
            500                 505                 510         


Leu Leu Ser Cys Asn Leu Lys Asp Asp Phe Glu Phe Phe Phe His His 
        515                 520                 525             


Arg Asn Asn Leu Asp Ile Asn Val Val Ile Arg Gln Val Tyr His Leu 
    530                 535                 540                 


Met Glu Thr Thr Pro Thr Asp Ile His Pro Asp Ser Met Leu Asn Val 
545                 550                 555                 560 


Phe Val Ala Leu Thr Lys Gly Gln Tyr Pro Val Phe Asn Gln Tyr Pro 
                565                 570                 575     


Lys Phe Ile Val Asp Tyr Gln Thr Gln Glu Arg Glu Arg Ile Arg Asn 
            580                 585                 590         


Asp Glu Leu Asp Tyr Leu Arg Glu Arg Gln Leu Lys Ile Cys Lys Leu 
        595                 600                 605             


Lys Ser Thr Ser Lys Glu Leu Lys Met Lys Leu Gly Thr Arg Asn Arg 
    610                 615                 620                 


Ser Cys Phe Val Lys Leu Lys Lys Gln Glu Glu Lys Cys Ser Tyr Lys 
625                 630                 635                 640 


Arg Arg Arg Lys 
                


<210> 6538
<211> 244
<212> PRT
<213> Homo sapiens

<400> 6538
Met Pro His Lys Ile Gly Phe Val Val Val Ser Ser Ser Gly His Glu 
1               5                   10                  15      


Asp Gly Phe Ser Ala Arg Glu Leu Met Ile His Ala Pro Thr Val Ser 
            20                  25                  30          


Gly Trp Arg Ser Pro Arg Phe Cys Gln Phe Pro Gln Glu Ile Val Leu 
        35                  40                  45              


Gln Met Val Glu Arg Cys Arg Ile Arg Lys Leu Gln Leu Leu Ala His 
    50                  55                  60                  


Gln Tyr Met Ile Ser Ser Lys Ile Glu Phe Tyr Ile Ser Glu Ser Leu 
65                  70                  75                  80  


Pro Glu Tyr Phe Ala Pro Tyr Gln Ala Glu Arg Phe Arg Arg Leu Gly 
                85                  90                  95      


Tyr Val Ser Leu Cys Asp Asn Glu Lys Thr Gly Cys Lys Ala Arg Glu 
            100                 105                 110         


Leu Lys Ser Val Tyr Val Asp Ala Val Gly Gln Phe Leu Lys Leu Ile 
        115                 120                 125             


Phe His Gln Asn His Val Asn Lys Tyr Asn Ile Tyr Asn Gln Val Ala 
    130                 135                 140                 


Leu Val Ala Ile Asn Ile Ile Gly Asp Pro Ala Asp Phe Ser Asp Glu 
145                 150                 155                 160 


Ser Asn Thr Ala Ser Arg Glu Lys Leu Ile Asp His Tyr Leu Gly His 
                165                 170                 175     


Asn Ser Glu Asp Pro Ala Leu Glu Gly Thr Tyr Ala Ser Ser Val Arg 
            180                 185                 190         


Thr Gly Gly Glu Ser Thr Phe Gly Glu Leu Lys Gly Pro Ala Val Pro 
        195                 200                 205             


Ser Ser Val Thr Leu Ser Val Leu Gly Thr Ser Leu Gly Gln Trp Phe 
    210                 215                 220                 


Pro Cys His Leu Pro Ala Val Asp Asp Asn Glu Gly Thr Pro Phe Gln 
225                 230                 235                 240 


Arg Cys Leu Val 
                


<210> 6539
<211> 925
<212> PRT
<213> Homo sapiens

<400> 6539
Met Pro His Lys Ile Gly Phe Val Val Val Ser Ser Ser Gly His Glu 
1               5                   10                  15      


Asp Gly Phe Ser Ala Arg Glu Leu Met Ile His Ala Pro Thr Val Ser 
            20                  25                  30          


Gly Trp Arg Ser Pro Arg Phe Cys Gln Phe Pro Gln Glu Ile Val Leu 
        35                  40                  45              


Gln Met Val Glu Arg Cys Arg Ile Arg Lys Leu Gln Leu Leu Ala His 
    50                  55                  60                  


Gln Tyr Met Ile Ser Ser Lys Ile Glu Phe Tyr Ile Ser Glu Ser Leu 
65                  70                  75                  80  


Pro Glu Tyr Phe Ala Pro Tyr Gln Ala Glu Arg Phe Arg Arg Leu Gly 
                85                  90                  95      


Tyr Val Ser Leu Cys Asp Asn Glu Lys Thr Gly Cys Lys Ala Arg Glu 
            100                 105                 110         


Leu Lys Ser Val Tyr Val Asp Ala Val Gly Gln Phe Leu Lys Leu Ile 
        115                 120                 125             


Phe His Gln Asn His Val Asn Lys Tyr Asn Ile Tyr Asn Gln Val Ala 
    130                 135                 140                 


Leu Val Ala Ile Asn Ile Ile Gly Asp Pro Ala Asp Phe Ser Asp Glu 
145                 150                 155                 160 


Ser Asn Thr Ala Ser Arg Glu Lys Leu Ile Asp His Tyr Leu Gly His 
                165                 170                 175     


Asn Ser Glu Asp Pro Ala Leu Glu Gly Thr Tyr Ala Arg Lys Ser Asp 
            180                 185                 190         


Tyr Ile Ser Pro Leu Asp Asp Leu Ala Phe Asp Met Tyr Gln Asp Pro 
        195                 200                 205             


Glu Val Ala Gln Ile Ile Arg Lys Leu Asp Glu Arg Lys Arg Glu Ala 
    210                 215                 220                 


Val Gln Lys Glu Arg Tyr Asp Tyr Ala Lys Lys Leu Lys Gln Ala Ile 
225                 230                 235                 240 


Ala Asp Leu Gln Lys Val Gly Glu Arg Leu Gly Arg Tyr Glu Val Glu 
                245                 250                 255     


Lys Arg Cys Ala Val Glu Lys Glu Asp Tyr Asp Leu Ala Lys Glu Lys 
            260                 265                 270         


Lys Gln Gln Met Glu Gln Tyr Arg Ala Glu Val Tyr Glu Gln Leu Glu 
        275                 280                 285             


Leu His Ser Leu Leu Asp Ala Glu Leu Met Arg Arg Pro Phe Asp Leu 
    290                 295                 300                 


Pro Leu Gln Pro Leu Ala Arg Ser Gly Ser Pro Cys His Gln Lys Pro 
305                 310                 315                 320 


Met Pro Ser Leu Pro Gln Leu Glu Glu Arg Gly Thr Glu Asn Gln Phe 
                325                 330                 335     


Ala Glu Pro Phe Leu Gln Glu Lys Pro Ser Ser Tyr Ser Leu Thr Ile 
            340                 345                 350         


Ser Pro Gln His Ser Ala Val Asp Pro Leu Leu Pro Ala Thr Asp Pro 
        355                 360                 365             


His Pro Lys Ile Asn Ala Glu Ser Leu Pro Tyr Asp Glu Arg Pro Leu 
    370                 375                 380                 


Pro Ala Ile Arg Lys His Tyr Gly Glu Ala Val Val Glu Pro Glu Met 
385                 390                 395                 400 


Ser Asn Ala Asp Ile Ser Asp Ala Arg Arg Gly Gly Met Leu Gly Glu 
                405                 410                 415     


Pro Glu Pro Leu Thr Glu Lys Ala Leu Arg Glu Ala Ser Ser Ala Ile 
            420                 425                 430         


Asp Val Leu Gly Glu Thr Leu Val Ala Glu Ala Tyr Cys Lys Thr Trp 
        435                 440                 445             


Ser Tyr Arg Glu Asp Ala Leu Leu Ala Leu Ser Lys Lys Leu Met Glu 
    450                 455                 460                 


Met Pro Val Gly Thr Pro Lys Glu Asp Leu Lys Asn Thr Leu Arg Ala 
465                 470                 475                 480 


Ser Val Phe Leu Val Arg Arg Ala Ile Lys Asp Ile Val Thr Ser Val 
                485                 490                 495     


Phe Gln Ala Ser Leu Lys Leu Leu Lys Met Ile Ile Thr Gln Tyr Ile 
            500                 505                 510         


Pro Lys His Lys Leu Ser Lys Leu Glu Thr Ala His Cys Val Glu Arg 
        515                 520                 525             


Thr Ile Pro Val Leu Leu Thr Arg Thr Gly Asp Ser Ser Ala Arg Leu 
    530                 535                 540                 


Arg Val Thr Ala Ala Asn Phe Ile Gln Glu Met Ala Leu Phe Lys Glu 
545                 550                 555                 560 


Val Lys Ser Leu Gln Ile Ile Pro Ser Tyr Leu Val Gln Pro Leu Lys 
                565                 570                 575     


Ala Asn Ser Ser Val His Leu Ala Met Ser Gln Met Gly Leu Leu Ala 
            580                 585                 590         


Arg Leu Leu Lys Asp Leu Gly Thr Gly Ser Ser Gly Phe Thr Ile Asp 
        595                 600                 605             


Asn Val Met Lys Phe Ser Val Ser Ala Leu Glu His Arg Val Tyr Glu 
    610                 615                 620                 


Val Arg Glu Thr Ala Val Arg Ile Ile Leu Asp Met Tyr Arg Gln His 
625                 630                 635                 640 


Gln Ala Ser Ile Leu Glu Tyr Leu Pro Pro Asp Asp Ser Asn Thr Arg 
                645                 650                 655     


Arg Asn Ile Leu Tyr Lys Thr Ile Phe Glu Gly Phe Ala Lys Ile Asp 
            660                 665                 670         


Gly Arg Ala Thr Asp Ala Glu Met Arg Ala Arg Arg Lys Ala Ala Thr 
        675                 680                 685             


Glu Glu Ala Glu Lys Gln Lys Lys Glu Glu Ile Lys Ala Leu Gln Gly 
    690                 695                 700                 


Gln Leu Ala Ala Leu Lys Glu Ile Gln Ala Glu Val Gln Glu Lys Glu 
705                 710                 715                 720 


Ser Asp Ala Val Lys Pro Lys Asn Gln Asp Ile Gln Gly Gly Lys Ala 
                725                 730                 735     


Ala Pro Ala Glu Ala Leu Gly Ile Pro Asp Glu His Tyr Leu Asp Asn 
            740                 745                 750         


Leu Cys Ile Phe Cys Gly Glu Arg Ser Glu Ser Phe Thr Glu Glu Gly 
        755                 760                 765             


Leu Asp Leu His Tyr Trp Lys His Cys Leu Met Leu Thr Arg Cys Asp 
    770                 775                 780                 


His Cys Lys Gln Val Val Glu Ile Ser Ser Leu Thr Glu His Leu Leu 
785                 790                 795                 800 


Thr Glu Cys Asp Lys Lys Asp Gly Phe Gly Lys Cys Tyr Arg Cys Ser 
                805                 810                 815     


Glu Ala Val Phe Lys Glu Glu Leu Pro Arg His Ile Lys His Lys Asp 
            820                 825                 830         


Cys Asn Pro Ala Lys Pro Glu Lys Leu Ala Asn Arg Cys Pro Leu Cys 
        835                 840                 845             


His Glu Asn Phe Ser Pro Gly Glu Glu Ala Trp Lys Ala His Leu Met 
    850                 855                 860                 


Gly Pro Ala Gly Cys Thr Met Asn Leu Arg Lys Thr His Ile Leu Gln 
865                 870                 875                 880 


Lys Ala Pro Ala Leu Gln Pro Gly Lys Ser Ser Ala Val Ala Ala Ser 
                885                 890                 895     


Gly Pro Leu Gly Ser Lys Ala Gly Ser Lys Ile Pro Thr Pro Lys Gly 
            900                 905                 910         


Gly Leu Ser Lys Ser Ser Ser Arg Thr Tyr Ala Lys Arg 
        915                 920                 925 


<210> 6540
<211> 714
<212> PRT
<213> Homo sapiens

<400> 6540
Met Ala Arg Ala Gly Ser Cys Gly Gly Ala Ala Ala Gly Ala Gly Arg 
1               5                   10                  15      


Pro Glu Pro Trp Glu Leu Ser Leu Glu Glu Val Leu Lys Ala Tyr Glu 
            20                  25                  30          


Gln Pro Leu Asn Glu Glu Gln Ala Trp Ala Val Cys Phe Gln Gly Cys 
        35                  40                  45              


Arg Gly Leu Arg Gly Ser Pro Gly Arg Arg Leu Arg Asp Thr Gly Asp 
    50                  55                  60                  


Leu Leu Leu Arg Gly Asp Gly Ser Val Gly Ala Arg Glu Pro Glu Ala 
65                  70                  75                  80  


Ala Glu Pro Ala Thr Met Val Val Pro Leu Ala Ser Ser Glu Ala Gln 
                85                  90                  95      


Thr Val Gln Ser Leu Gly Phe Ala Ile Tyr Arg Ala Leu Asp Trp Gly 
            100                 105                 110         


Leu Asp Glu Ser Glu Glu Arg Glu Leu Ser Pro Gln Leu Glu Arg Leu 
        115                 120                 125             


Ile Asp Leu Met Ala Asn Asn Asp Ser Glu Asp Ser Gly Cys Gly Ala 
    130                 135                 140                 


Ala Asp Glu Gly Tyr Gly Gly Pro Glu Glu Glu Glu Glu Ala Glu Gly 
145                 150                 155                 160 


Val Pro Arg Ser Val Arg Thr Phe Ala Gln Ala Met Arg Leu Cys Ala 
                165                 170                 175     


Ala Arg Leu Thr Asp Pro Arg Gly Ala Gln Ala His Tyr Gln Ala Val 
            180                 185                 190         


Cys Arg Ala Leu Phe Val Glu Thr Leu Glu Leu Arg Ala Phe Leu Ala 
        195                 200                 205             


Arg Val Arg Glu Ala Lys Glu Met Leu Gln Lys Leu Arg Glu Asp Glu 
    210                 215                 220                 


Pro His Leu Glu Thr Pro Arg Ala Glu Leu Asp Ser Leu Gly His Thr 
225                 230                 235                 240 


Asp Trp Ala Arg Leu Trp Val Gln Leu Met Arg Glu Leu Arg Arg Gly 
                245                 250                 255     


Val Lys Leu Lys Lys Val Gln Glu Gln Glu Phe Asn Pro Leu Pro Thr 
            260                 265                 270         


Glu Phe Gln Leu Thr Pro Phe Glu Met Leu Met Gln Asp Ile Arg Ala 
        275                 280                 285             


Arg Asn Tyr Lys Leu Arg Lys Val Met Val Asp Gly Asp Ile Pro Pro 
    290                 295                 300                 


Arg Val Lys Lys Asp Ala His Glu Leu Ile Leu Asp Phe Ile Arg Ser 
305                 310                 315                 320 


Arg Pro Pro Leu Lys Gln Val Ser Glu Arg Arg Leu Arg Pro Leu Pro 
                325                 330                 335     


Pro Lys Gln Arg Ser Leu His Glu Lys Ile Leu Glu Glu Ile Lys Gln 
            340                 345                 350         


Glu Arg Arg Leu Arg Pro Val Arg Gly Glu Gly Trp Ala Ala Arg Gly 
        355                 360                 365             


Phe Gly Ser Leu Pro Cys Ile Leu Asn Ala Cys Ser Gly Asp Ala Lys 
    370                 375                 380                 


Ser Thr Ser Cys Ile Asn Leu Ser Val Thr Asp Ala Gly Gly Ser Ala 
385                 390                 395                 400 


Gln Arg Pro Arg Pro Arg Val Leu Leu Lys Ala Pro Thr Leu Ala Glu 
                405                 410                 415     


Met Glu Glu Met Asn Thr Ser Glu Glu Glu Glu Ser Pro Cys Gly Glu 
            420                 425                 430         


Val Thr Leu Lys Arg Asp Arg Ser Phe Ser Glu His Asp Leu Ala Gln 
        435                 440                 445             


Leu Arg Ser Glu Val Ala Ser Gly Leu Gln Ser Ala Thr His Pro Pro 
    450                 455                 460                 


Gly Gly Thr Glu Pro Pro Arg Pro Arg Ala Gly Ser Ala His Val Trp 
465                 470                 475                 480 


Arg Pro Gly Ser Arg Asp Gln Gly Thr Cys Pro Ala Ser Val Ser Asp 
                485                 490                 495     


Pro Ser His Pro Leu Leu Ser Asn Arg Gly Ser Ser Gly Asp Arg Pro 
            500                 505                 510         


Glu Ala Ser Met Thr Pro Asp Ala Lys His Leu Trp Leu Glu Phe Ser 
        515                 520                 525             


His Pro Val Glu Ser Leu Ala Leu Thr Val Glu Glu Val Met Asp Val 
    530                 535                 540                 


Arg Arg Val Leu Val Lys Ala Glu Met Glu Lys Phe Leu Gln Asn Lys 
545                 550                 555                 560 


Glu Leu Phe Ser Ser Leu Lys Lys Gly Lys Ile Cys Cys Cys Cys Arg 
                565                 570                 575     


Ala Lys Phe Pro Leu Phe Ser Trp Pro Pro Ser Cys Leu Phe Cys Lys 
            580                 585                 590         


Arg Ala Val Cys Thr Ser Cys Ser Ile Lys Met Lys Met Pro Ser Lys 
        595                 600                 605             


Lys Phe Gly His Ile Pro Val Tyr Thr Leu Gly Phe Glu Ser Pro Gln 
    610                 615                 620                 


Arg Val Ser Ala Ala Lys Thr Ala Pro Ile Gln Arg Arg Asp Ile Phe 
625                 630                 635                 640 


Gln Ser Leu Gln Gly Pro Gln Trp Gln Ser Val Glu Glu Ala Phe Pro 
                645                 650                 655     


His Ile Tyr Ser His Gly Cys Val Leu Lys Asp Val Cys Ser Glu Cys 
            660                 665                 670         


Thr Ser Phe Val Ala Asp Val Val Arg Ser Ser Arg Lys Ser Val Asp 
        675                 680                 685             


Val Leu Asn Thr Thr Pro Arg Arg Ser Arg Gln Thr Gln Ser Leu Tyr 
    690                 695                 700                 


Ile Pro Asn Thr Arg Thr Leu Asp Phe Lys 
705                 710                 


<210> 6541
<211> 435
<212> PRT
<213> Homo sapiens

<400> 6541
Met Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe 
1               5                   10                  15      


Ser Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val 
            20                  25                  30          


Val Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu 
        35                  40                  45              


Asp Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu 
    50                  55                  60                  


Cys Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln 
65                  70                  75                  80  


Pro Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala 
                85                  90                  95      


Ser Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe 
            100                 105                 110         


His Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr 
        115                 120                 125             


Ile Lys Tyr Pro Lys Ala Cys Leu Gln Gly Ile Thr Phe Thr Arg Asp 
    130                 135                 140                 


Gly Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val 
145                 150                 155                 160 


Ser Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg His Phe Asp Thr 
                165                 170                 175     


Asp Thr Gln Asp Leu Thr Gly Ile Glu Trp Ala Pro Asn Gly Cys Val 
            180                 185                 190         


Leu Ala Val Trp Asp Thr Cys Leu Glu Tyr Lys Ile Leu Leu Tyr Ser 
        195                 200                 205             


Leu Asp Gly Arg Leu Leu Ser Thr Tyr Ser Ala Tyr Glu Trp Ser Leu 
    210                 215                 220                 


Gly Ile Lys Ser Val Ala Trp Ser Pro Ser Ser Gln Phe Leu Ala Val 
225                 230                 235                 240 


Gly Ser Tyr Asp Gly Lys Val Arg Ile Leu Asn His Val Thr Trp Lys 
                245                 250                 255     


Met Ile Thr Glu Phe Gly His Pro Ala Ala Ile Asn Asp Pro Lys Ile 
            260                 265                 270         


Val Val Tyr Lys Glu Ala Glu Lys Ser Pro Gln Leu Gly Leu Gly Cys 
        275                 280                 285             


Leu Ser Phe Pro Pro Pro Arg Ala Gly Ala Gly Pro Leu Pro Ser Ser 
    290                 295                 300                 


Glu Ser Lys Tyr Glu Ile Ala Ser Val Pro Val Ser Leu Gln Thr Leu 
305                 310                 315                 320 


Lys Pro Val Thr Asp Arg Ala Asn Pro Lys Ile Gly Ile Gly Met Leu 
                325                 330                 335     


Ala Phe Ser Pro Asp Ser Tyr Phe Leu Ala Thr Arg Asn Asp Asn Ile 
            340                 345                 350         


Pro Asn Ala Val Trp Val Trp Asp Ile Gln Lys Leu Arg Leu Phe Ala 
        355                 360                 365             


Val Leu Glu Gln Leu Ser Pro Val Arg Ala Phe Gln Trp Asp Pro Gln 
    370                 375                 380                 


Gln Pro Arg Leu Ala Ile Cys Thr Gly Gly Ser Arg Leu Tyr Leu Trp 
385                 390                 395                 400 


Ser Pro Ala Gly Cys Met Ser Val Gln Val Pro Gly Glu Gly Lys His 
                405                 410                 415     


Ile Pro Glu Ala Thr Asp Val Ala Ala Leu Leu Cys Ala Val Trp His 
            420                 425                 430         


His Thr Gly 
        435 


<210> 6542
<211> 272
<212> PRT
<213> Homo sapiens

<400> 6542
Met Leu Gln Leu Arg Asp Ser Val Asp Ser Ala Gly Thr Ser Pro Thr 
1               5                   10                  15      


Ala Val Leu Ala Ala Gly Glu Glu Val Gly Ala Gly Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Arg Pro Gly Ala Gly Thr Pro Leu Arg Gln Thr Leu Trp Pro 
        35                  40                  45              


Leu Ser Ile His Asp Pro Thr Arg Arg Ala Arg Val Lys Glu Tyr Phe 
    50                  55                  60                  


Val Phe Arg Pro Gly Ser Ile Glu Gln Ala Val Glu Glu Ile Arg Val 
65                  70                  75                  80  


Val Val Arg Pro Val Glu Asp Gly Glu Ile Gln Gly Val Trp Leu Leu 
                85                  90                  95      


Thr Glu Val Asp His Trp Asn Asn Glu Lys Glu Arg Leu Val Leu Val 
            100                 105                 110         


Thr Glu Gln Ser Leu Leu Ile Cys Lys Tyr Asp Phe Ile Ser Leu Gln 
        115                 120                 125             


Cys Gln Gln Val Val Arg Ile Ala Leu Asn Ala Val Asp Thr Ile Ser 
    130                 135                 140                 


Tyr Gly Glu Phe Gln Phe Pro Pro Lys Ser Leu Asn Lys Arg Glu Gly 
145                 150                 155                 160 


Phe Gly Ile Arg Ile Gln Trp Asp Lys Gln Ser Arg Pro Ser Phe Ile 
                165                 170                 175     


Asn Arg Trp Asn Pro Trp Ser Thr Asn Val Pro Tyr Ala Thr Phe Thr 
            180                 185                 190         


Glu His Pro Met Ala Gly Ala Asp Glu Lys Thr Ala Ser Leu Cys Gln 
        195                 200                 205             


Leu Glu Ser Phe Lys Ala Leu Leu Ile Gln Ala Val Lys Lys Ala Gln 
    210                 215                 220                 


Lys Glu Ser Pro Leu Pro Gly Gln Ala Asn Gly Val Leu Ile Leu Glu 
225                 230                 235                 240 


Arg Pro Leu Leu Ile Glu Thr Tyr Val Gly Leu Met Ser Phe Ile Asn 
                245                 250                 255     


Asn Glu Ala Lys Leu Gly Tyr Ser Met Thr Arg Gly Lys Ile Gly Phe 
            260                 265                 270         


<210> 6543
<211> 289
<212> PRT
<213> Homo sapiens

<400> 6543
Met Trp Pro Phe Pro Ser Arg Ser Leu Phe Pro Pro Pro Thr Gln Ala 
1               5                   10                  15      


Trp Leu Gln Thr Val Ser Ser Asp Pro Glu Ala Gln Gly Trp Gly Ala 
            20                  25                  30          


Trp Asn Glu Thr Lys Glu Ile Leu Gly Pro Glu Gly Gly Glu Gly Lys 
        35                  40                  45              


Glu Glu Lys Glu Glu Glu Glu Asp Ala Glu Glu Asp Gln Asp Gly Asp 
    50                  55                  60                  


Ala Gly Phe Leu Leu Ser Leu Leu Glu Gln Glu Asn Leu Ala Glu Cys 
65                  70                  75                  80  


Pro Leu Pro Asp Gln Glu Leu Glu Ala Ile Lys Met Lys Val Cys Ala 
                85                  90                  95      


Met Glu Gln Ala Glu Gly Thr Pro Arg Pro Pro Gly Val Gln Gln Gln 
            100                 105                 110         


Ala Glu Glu Glu Glu Gly Thr Ala Ala Gly Gln Leu Leu Ser Pro Glu 
        115                 120                 125             


Thr Val Gly Cys Pro Leu Ser Gly Thr Pro Glu Glu Lys Val Glu Ala 
    130                 135                 140                 


Asp His Arg Ser Val Tyr Val Gly Asn Val Asp Tyr Gly Gly Ser Ala 
145                 150                 155                 160 


Glu Glu Leu Glu Ala His Phe Ser Arg Cys Gly Glu Val His Arg Val 
                165                 170                 175     


Thr Ile Leu Cys Asp Lys Phe Ser Gly His Pro Lys Gly Tyr Ala Tyr 
            180                 185                 190         


Ile Glu Phe Ala Thr Lys Gly Ser Val Gln Ala Ala Val Glu Leu Asp 
        195                 200                 205             


Gln Ser Leu Phe Arg Gly Arg Val Ile Lys Val Leu Pro Lys Arg Thr 
    210                 215                 220                 


Asn Phe Pro Gly Ile Ser Ser Thr Asp Arg Gly Gly Leu Arg Gly His 
225                 230                 235                 240 


Pro Gly Ser Arg Gly Ala Pro Phe Pro His Ser Gly Leu Gln Gly Arg 
                245                 250                 255     


Pro Arg Leu Arg Pro Gln Gly Gln Asn Arg Thr Pro Ala Ala Leu Thr 
            260                 265                 270         


Pro Leu Trp Ala Arg Pro Leu Pro Trp Val Val Val Ser His Val Ile 
        275                 280                 285             


Lys 
    


<210> 6544
<211> 421
<212> PRT
<213> Homo sapiens

<400> 6544
Met Phe Glu Ile Leu Thr Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
1               5                   10                  15      


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Thr Val 
            20                  25                  30          


Thr Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
        35                  40                  45              


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
    50                  55                  60                  


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
65                  70                  75                  80  


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
                85                  90                  95      


Gln Arg Thr Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
            100                 105                 110         


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
        115                 120                 125             


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Thr Arg Leu Pro Leu 
    130                 135                 140                 


Leu Met Asp Thr Leu Cys Leu Lys Thr Gln Gly His Ser Glu Arg Tyr 
145                 150                 155                 160 


Lys Ala Ala Ser Arg Ala Leu Lys Ala Ile Ser Lys Leu Val Arg Gln 
                165                 170                 175     


Cys Asn Glu Gly Ala His Arg Met Glu Arg Met Glu Gln Met Tyr Thr 
            180                 185                 190         


Leu His Thr Gln Leu Asp Phe Ser Lys Val Lys Ser Leu Pro Leu Ile 
        195                 200                 205             


Ser Ala Ser Arg Trp Leu Leu Lys Arg Gly Glu Leu Phe Leu Val Glu 
    210                 215                 220                 


Glu Thr Gly Leu Phe Arg Lys Ile Ala Ser Arg Pro Thr Cys Tyr Leu 
225                 230                 235                 240 


Phe Leu Phe Asn Asp Val Leu Val Val Thr Lys Lys Lys Ser Glu Glu 
                245                 250                 255     


Ser Tyr Met Val Gln Asp Tyr Ala Gln Met Asn His Ile Gln Val Glu 
            260                 265                 270         


Lys Ile Glu Pro Ser Glu Leu Pro Leu Pro Gly Gly Gly Asn Arg Ser 
        275                 280                 285             


Ser Ser Val Pro His Pro Phe Gln Val Thr Leu Leu Arg Asn Ser Glu 
    290                 295                 300                 


Gly Arg Gln Glu Gln Leu Leu Leu Ser Ser Asp Ser Ala Ser Asp Arg 
305                 310                 315                 320 


Ala Arg Trp Ile Val Ala Leu Thr His Ser Glu Arg Gln Trp Gln Gly 
                325                 330                 335     


Leu Ser Ser Lys Gly Asp Leu Pro Gln Val Glu Ile Thr Lys Ala Phe 
            340                 345                 350         


Phe Ala Lys Gln Ala Asp Glu Val Thr Leu Gln Gln Ala Asp Val Val 
        355                 360                 365             


Leu Val Leu Gln Gln Glu Asp Gly Trp Leu Tyr Gly Glu Arg Leu Arg 
    370                 375                 380                 


Asp Gly Glu Thr Gly Trp Phe Pro Glu Asp Phe Ala Arg Phe Ile Thr 
385                 390                 395                 400 


Ser Arg Val Ala Val Glu Gly Asn Val Arg Arg Met Glu Arg Leu Arg 
                405                 410                 415     


Val Glu Thr Asp Val 
            420     


<210> 6545
<211> 421
<212> PRT
<213> Homo sapiens

<400> 6545
Met Phe Glu Ile Leu Thr Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
1               5                   10                  15      


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Thr Val 
            20                  25                  30          


Thr Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
        35                  40                  45              


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
    50                  55                  60                  


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
65                  70                  75                  80  


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
                85                  90                  95      


Gln Arg Thr Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
            100                 105                 110         


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
        115                 120                 125             


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Thr Arg Leu Pro Leu 
    130                 135                 140                 


Leu Met Asp Thr Leu Cys Leu Lys Thr Gln Gly His Ser Glu Arg Tyr 
145                 150                 155                 160 


Lys Ala Ala Ser Arg Ala Leu Lys Ala Ile Ser Lys Leu Val Arg Gln 
                165                 170                 175     


Cys Asn Glu Gly Ala His Arg Met Glu Arg Met Glu Gln Met Tyr Thr 
            180                 185                 190         


Leu His Thr Gln Leu Asp Phe Ser Lys Val Lys Ser Leu Pro Leu Ile 
        195                 200                 205             


Ser Ala Ser Arg Trp Leu Leu Lys Arg Gly Glu Leu Phe Leu Val Glu 
    210                 215                 220                 


Glu Thr Gly Leu Phe Arg Lys Ile Ala Ser Arg Pro Thr Cys Tyr Leu 
225                 230                 235                 240 


Phe Leu Phe Asn Asp Val Leu Val Val Thr Lys Lys Lys Ser Glu Glu 
                245                 250                 255     


Ser Tyr Met Val Gln Asp Tyr Ala Gln Met Asn His Ile Gln Val Glu 
            260                 265                 270         


Lys Ile Glu Pro Ser Glu Leu Pro Leu Pro Gly Gly Gly Asn Arg Ser 
        275                 280                 285             


Ser Ser Val Pro His Pro Phe Gln Val Thr Leu Leu Arg Asn Ser Glu 
    290                 295                 300                 


Gly Arg Gln Glu Gln Leu Leu Leu Ser Ser Asp Ser Ala Ser Asp Arg 
305                 310                 315                 320 


Ala Arg Trp Ile Val Ala Leu Thr His Ser Glu Arg Gln Trp Gln Gly 
                325                 330                 335     


Leu Ser Ser Lys Gly Asp Leu Pro Gln Val Glu Ile Thr Lys Ala Phe 
            340                 345                 350         


Phe Ala Lys Gln Ala Asp Glu Val Thr Leu Gln Gln Ala Asp Val Val 
        355                 360                 365             


Leu Val Leu Gln Gln Glu Asp Gly Trp Leu Tyr Gly Glu Arg Leu Arg 
    370                 375                 380                 


Asp Gly Glu Thr Gly Trp Phe Pro Glu Asp Phe Ala Arg Phe Ile Thr 
385                 390                 395                 400 


Ser Arg Val Ala Val Glu Gly Asn Val Arg Arg Met Glu Arg Leu Arg 
                405                 410                 415     


Val Glu Thr Asp Val 
            420     


<210> 6546
<211> 709
<212> PRT
<213> Homo sapiens

<400> 6546
Met Ala Gln Arg His Ser Asp Ser Ser Leu Glu Glu Lys Leu Leu Gly 
1               5                   10                  15      


His Arg Phe His Ser Glu Leu Arg Leu Asp Ala Gly Gly Asn Pro Ala 
            20                  25                  30          


Ser Gly Leu Pro Met Val Arg Gly Ser Pro Arg Val Arg Asp Asp Ala 
        35                  40                  45              


Ala Phe Gln Pro Gln Val Pro Ala Pro Pro Gln Pro Arg Pro Pro Gly 
    50                  55                  60                  


His Glu Glu Pro Trp Pro Ile Val Leu Ser Thr Glu Ser Pro Ala Ala 
65                  70                  75                  80  


Leu Lys Leu Gly Thr Gln Gln Leu Ile Pro Lys Ser Leu Ala Val Ala 
                85                  90                  95      


Ser Lys Ala Lys Thr Pro Ala Arg His Gln Ser Phe Gly Ala Ala Val 
            100                 105                 110         


Leu Ser Arg Glu Ala Ala Arg Arg Asp Pro Lys Leu Leu Pro Ala Pro 
        115                 120                 125             


Ser Phe Ser Leu Asp Asp Met Asp Val Asp Lys Asp Pro Gly Gly Met 
    130                 135                 140                 


Leu Arg Arg Asn Leu Arg Asn Gln Ser Tyr Arg Ala Ala Met Lys Gly 
145                 150                 155                 160 


Leu Gly Lys Pro Gly Gly Gln Gly Asp Ala Ile Gln Leu Ser Pro Lys 
                165                 170                 175     


Leu Gln Ala Leu Ala Glu Glu Pro Ser Gln Pro His Thr Arg Ser Pro 
            180                 185                 190         


Ala Lys Asn Lys Lys Thr Leu Gly Arg Lys Arg Gly His Lys Gly Ser 
        195                 200                 205             


Phe Lys Asp Asp Pro Gln Leu Tyr Gln Glu Ile Gln Glu Arg Gly Leu 
    210                 215                 220                 


Asn Thr Ser Gln Glu Ser Asp Asp Asp Ile Leu Asp Glu Ser Ser Ser 
225                 230                 235                 240 


Pro Glu Gly Thr Gln Lys Val Asp Ala Thr Ile Val Val Lys Ser Tyr 
                245                 250                 255     


Arg Pro Ala Gln Val Thr Trp Ser Gln Leu Pro Glu Val Val Glu Leu 
            260                 265                 270         


Gly Ile Leu Asp Gln Leu Ser Thr Glu Glu Arg Lys Arg Gln Glu Ala 
        275                 280                 285             


Met Phe Glu Ile Leu Thr Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
    290                 295                 300                 


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Thr Val 
305                 310                 315                 320 


Thr Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
                325                 330                 335     


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
            340                 345                 350         


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
        355                 360                 365             


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
    370                 375                 380                 


Gln Arg Thr Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
385                 390                 395                 400 


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
                405                 410                 415     


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Thr Arg Leu Pro Leu 
            420                 425                 430         


Leu Met Asp Thr Leu Cys Leu Lys Thr Gln Gly His Ser Glu Arg Tyr 
        435                 440                 445             


Lys Ala Ala Ser Arg Ala Leu Lys Ala Ile Ser Lys Leu Val Arg Gln 
    450                 455                 460                 


Cys Asn Glu Gly Ala His Arg Met Glu Arg Met Glu Gln Met Tyr Thr 
465                 470                 475                 480 


Leu His Thr Gln Leu Asp Phe Ser Lys Val Lys Ser Leu Pro Leu Ile 
                485                 490                 495     


Ser Ala Ser Arg Trp Leu Leu Lys Arg Gly Glu Leu Phe Leu Val Glu 
            500                 505                 510         


Glu Thr Gly Leu Phe Arg Lys Ile Ala Ser Arg Pro Thr Cys Tyr Leu 
        515                 520                 525             


Phe Leu Phe Asn Asp Val Leu Val Val Thr Lys Lys Lys Ser Glu Glu 
    530                 535                 540                 


Ser Tyr Met Val Gln Asp Tyr Ala Gln Met Asn His Ile Gln Val Glu 
545                 550                 555                 560 


Lys Ile Glu Pro Ser Glu Leu Pro Leu Pro Gly Gly Gly Asn Arg Ser 
                565                 570                 575     


Ser Ser Val Pro His Pro Phe Gln Val Thr Leu Leu Arg Asn Ser Glu 
            580                 585                 590         


Gly Arg Gln Glu Gln Leu Leu Leu Ser Ser Asp Ser Ala Ser Asp Arg 
        595                 600                 605             


Ala Arg Trp Ile Val Ala Leu Thr His Ser Glu Arg Gln Trp Gln Gly 
    610                 615                 620                 


Leu Ser Ser Lys Gly Asp Leu Pro Gln Val Glu Ile Thr Lys Ala Phe 
625                 630                 635                 640 


Phe Ala Lys Gln Ala Asp Glu Val Thr Leu Gln Gln Ala Asp Val Val 
                645                 650                 655     


Leu Val Leu Gln Gln Glu Asp Gly Trp Leu Tyr Gly Glu Arg Leu Arg 
            660                 665                 670         


Asp Gly Glu Thr Gly Trp Phe Pro Glu Asp Phe Ala Arg Phe Ile Thr 
        675                 680                 685             


Ser Arg Val Ala Val Glu Gly Asn Val Arg Arg Met Glu Arg Leu Arg 
    690                 695                 700                 


Val Glu Thr Asp Val 
705                 


<210> 6547
<211> 428
<212> PRT
<213> Homo sapiens

<400> 6547
Met Val Trp Gln Val Leu Glu Gly Leu Ser Gln Asp Ser Ala Lys Arg 
1               5                   10                  15      


Leu Arg Phe Val Ala Gly Val Ile Phe Val Asp Glu Gly Ala Ala Cys 
            20                  25                  30          


Gly Gln Ser Leu Glu Glu Arg Ser Lys Thr Leu Ala Glu Val Lys Pro 
        35                  40                  45              


Ile Leu Gln Ala Thr Gly Phe Pro Trp His Val Val Ala Leu Glu Glu 
    50                  55                  60                  


Val Phe Ser Leu Pro Pro Ser Val Leu Trp Cys Ser Ala Gln Glu Leu 
65                  70                  75                  80  


Val Gly Ser Glu Gly Ala Tyr Lys Ala Ala Val Asp Ser Phe Leu Gln 
                85                  90                  95      


Gln Gln His Val Leu Gly Ala Gly Gly Gly Pro Gly Pro Thr Gln Gly 
            100                 105                 110         


Glu Glu Gln Pro Pro Gln Pro Pro Leu Asp Pro Gln Asn Leu Ala Arg 
        115                 120                 125             


Pro Pro Ala Pro Ala Gln Thr Glu Ala Leu Ser Gln Leu Phe Cys Ser 
    130                 135                 140                 


Val Arg Thr Leu Thr Ala Lys Glu Glu Leu Leu Gln Thr Leu Arg Thr 
145                 150                 155                 160 


His Leu Ile Leu His Met Ala Arg Ala His Gly Tyr Ser Lys Val Met 
                165                 170                 175     


Thr Gly Asp Ser Cys Thr Arg Leu Ala Ile Lys Leu Met Thr Asn Leu 
            180                 185                 190         


Ala Leu Gly Arg Gly Ala Phe Leu Ala Trp Asp Thr Gly Phe Ser Asp 
        195                 200                 205             


Glu Arg His Gly Asp Val Val Val Val Arg Pro Met Arg Asp His Thr 
    210                 215                 220                 


Leu Lys Glu Val Ala Phe Tyr Asn Arg Leu Phe Ser Val Pro Ser Val 
225                 230                 235                 240 


Phe Thr Pro Ala Val Asp Thr Lys Ala Pro Glu Lys Ala Ser Ile His 
                245                 250                 255     


Arg Leu Met Glu Ala Phe Ile Leu Arg Leu Gln Thr Gln Phe Pro Ser 
            260                 265                 270         


Thr Val Ser Thr Val Tyr Arg Thr Ser Glu Lys Leu Val Lys Gly Pro 
        275                 280                 285             


Arg Asp Gly Pro Ala Ala Gly Asp Ser Gly Pro Arg Cys Leu Leu Cys 
    290                 295                 300                 


Met Cys Ala Leu Asp Val Asp Ala Ala Asp Ser Ala Thr Ala Phe Gly 
305                 310                 315                 320 


Ala Gln Thr Ser Ser Arg Leu Ser Gln Met Gln Ser Pro Ile Pro Leu 
                325                 330                 335     


Thr Glu Thr Arg Thr Pro Pro Gly Pro Cys Cys Ser Pro Gly Val Gly 
            340                 345                 350         


Trp Ala Gln Arg Cys Gly Gln Gly Ala Cys Arg Arg Glu Asp Pro Gln 
        355                 360                 365             


Ala Cys Ile Glu Glu Gln Leu Cys Tyr Ser Cys Arg Val Asn Met Lys 
    370                 375                 380                 


Asp Leu Pro Ser Leu Asp Pro Leu Pro Pro Tyr Ile Leu Ala Glu Ala 
385                 390                 395                 400 


Gln Leu Arg Thr Gln Arg Ala Trp Gly Leu Gln Glu Ile Arg Asp Cys 
                405                 410                 415     


Leu Ile Glu Asp Ser Asp Asp Glu Ala Gly Gln Ser 
            420                 425             


<210> 6548
<211> 138
<212> PRT
<213> Homo sapiens

<400> 6548
Met Gly Glu Gln Ala Asp Gly Lys Asp Ser Ile Ala Arg Gln Val Ala 
1               5                   10                  15      


Pro Glu Ser His Trp Pro Glu Leu Arg Val Leu Ile Leu Val Val Ser 
            20                  25                  30          


Ala Glu Lys Lys Leu Thr Gly Ser Thr Val Gly Met Arg Ala Ser Val 
        35                  40                  45              


Glu Thr Ser Pro Leu Leu Arg Phe Arg Ala Glu Ser Val Val Pro Ala 
    50                  55                  60                  


His Gly Gly Asp Gly Pro Leu His Pro Gly Ala Arg Leu Pro Gln Leu 
65                  70                  75                  80  


Arg Pro Ala Asp His Glu Gly Gln Gln Pro Val Pro Arg His Leu Pro 
                85                  90                  95      


Arg His Leu Pro Pro Ser Leu Thr Ser Met Pro Ser Pro Gly Ala Ser 
            100                 105                 110         


Ser Thr Trp Cys Thr Ala Ser Thr Pro Thr Thr Gly Thr Pro Arg Trp 
        115                 120                 125             


Arg Thr Pro Leu Thr Arg Ala Pro Met Pro 
    130                 135             


<210> 6549
<211> 198
<212> PRT
<213> Homo sapiens

<400> 6549
Met Ser Thr Val Asp Leu Ala Arg Val Gly Ala Cys Ile Leu Lys His 
1               5                   10                  15      


Ala Val Thr Gly Glu Ala Val Glu Leu Arg Ser Leu Trp Arg Glu His 
            20                  25                  30          


Ala Cys Val Val Ala Gly Leu Arg Arg Phe Gly Cys Val Val Cys Arg 
        35                  40                  45              


Trp Ile Ala Gln Asp Leu Ser Ser Leu Ala Gly Leu Leu Asp Gln His 
    50                  55                  60                  


Gly Val Arg Leu Val Gly Val Gly Pro Glu Ala Leu Gly Leu Gln Glu 
65                  70                  75                  80  


Phe Leu Asp Gly Asp Tyr Phe Ala Gly Glu Leu Tyr Leu Asp Glu Ser 
                85                  90                  95      


Lys Gln Leu Tyr Lys Glu Leu Gly Phe Lys Arg Tyr Asn Ser Leu Ser 
            100                 105                 110         


Ile Leu Pro Ala Ala Leu Gly Lys Pro Val Arg Asp Val Ala Ala Lys 
        115                 120                 125             


Ala Lys Ala Val Gly Ile Gln Gly Asn Leu Ser Gly Asp Leu Leu Gln 
    130                 135                 140                 


Ser Gly Gly Leu Leu Val Val Ser Lys Gly Gly Asp Lys Val Leu Leu 
145                 150                 155                 160 


His Phe Val Gln Lys Ser Pro Gly Asp Tyr Val Pro Lys Glu His Ile 
                165                 170                 175     


Leu Gln Val Leu Gly Ile Ser Ala Glu Val Cys Ala Ser Asp Pro Pro 
            180                 185                 190         


Gln Cys Asp Arg Glu Val 
        195             


<210> 6550
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6550
Xaa Ser Arg Glu Arg Gly Ser Arg Ser Glu Glu Pro Gly Ala Gly Asn 
1               5                   10                  15      


Arg Glu Ser Gly Ser Arg Glu Pro Gly Leu Ala Ala Ala Ala Met Ser 
            20                  25                  30          


Thr Val Asp Leu Ala Arg Val Gly Ala Cys Ile Leu Lys His Ala Val 
        35                  40                  45              


Thr Gly Glu Ala Val Glu Leu Arg Ser Leu Trp Arg Glu His Ala Cys 
    50                  55                  60                  


Val Val Ala Gly Leu Arg Arg Phe Gly Cys Val Val Cys Arg Trp Ile 
65                  70                  75                  80  


Ala Gln Asp Leu Ser Ser Leu Ala Gly Leu Leu Asp Gln His Gly Val 
                85                  90                  95      


Arg Leu Val Gly Val Gly Pro Glu Ala Leu Gly Leu Gln Glu Phe Leu 
            100                 105                 110         


Asp Gly Asp Tyr Phe Ala Gly Glu Leu Tyr Leu Asp Glu Ser Lys Gln 
        115                 120                 125             


Leu Tyr Lys Glu Leu Gly Phe Lys Arg Tyr Asn Ser Leu Ser Ile Leu 
    130                 135                 140                 


Pro Ala Ala Leu Gly Lys Pro Val Arg Asp Val Ala Ala Lys Ala Lys 
145                 150                 155                 160 


Ala Val Gly Ile Gln Gly Asn Leu Ser Gly Asp Leu Leu Gln Ser Gly 
                165                 170                 175     


Gly Leu Leu Val Val Ser Lys Glu Val Pro Arg Arg Leu Arg Pro Gln 
            180                 185                 190         


Gly Ala His Pro Ala Gly Pro Gly His Leu Cys Gly Gly Leu Cys Gln 
        195                 200                 205             


Arg Pro Ala Ser Val 
    210             


<210> 6551
<211> 850
<212> PRT
<213> Homo sapiens

<400> 6551
Met Ala Glu Val Glu Ala Val Gln Leu Lys Glu Glu Gly Asn Arg His 
1               5                   10                  15      


Phe Gln Leu Gln Asp Tyr Lys Ala Ala Thr Asn Ser Tyr Ser Gln Ala 
            20                  25                  30          


Leu Lys Leu Thr Lys Asp Lys Ala Leu Leu Ala Thr Leu Tyr Arg Asn 
        35                  40                  45              


Arg Ala Ala Cys Gly Leu Lys Thr Glu Ser Tyr Val Gln Ala Ala Ser 
    50                  55                  60                  


Asp Ala Ser Arg Ala Ile Asp Ile Asn Ser Ser Asp Ile Lys Ala Leu 
65                  70                  75                  80  


Tyr Arg Arg Cys Gln Ala Leu Glu His Leu Gly Lys Leu Asp Gln Ala 
                85                  90                  95      


Phe Lys Asp Val Gln Arg Cys Ala Thr Leu Glu Pro Arg Asn Gln Asn 
            100                 105                 110         


Phe Gln Glu Met Leu Arg Arg Leu Asn Thr Ser Ile Gln Glu Lys Leu 
        115                 120                 125             


Arg Val Gln Phe Ser Thr Asp Ser Arg Val Gln Lys Met Phe Glu Ile 
    130                 135                 140                 


Leu Leu Asp Glu Asn Ser Glu Ala Asp Lys Arg Glu Lys Ala Ala Asn 
145                 150                 155                 160 


Asn Leu Ile Val Leu Gly Arg Glu Glu Ala Gly Ala Glu Lys Ile Phe 
                165                 170                 175     


Gln Asn Asn Gly Val Ala Leu Leu Leu Gln Leu Leu Asp Thr Lys Lys 
            180                 185                 190         


Pro Glu Leu Val Leu Ala Ala Val Arg Thr Leu Ser Gly Met Cys Ser 
        195                 200                 205             


Gly His Gln Ala Arg Ala Thr Val Ile Leu His Ala Val Arg Ile Asp 
    210                 215                 220                 


Arg Ile Cys Ser Leu Met Ala Val Glu Asn Glu Glu Met Ser Leu Ala 
225                 230                 235                 240 


Val Cys Asn Leu Leu Gln Ala Ile Ile Asp Ser Leu Ser Gly Glu Asp 
                245                 250                 255     


Lys Arg Glu His Arg Gly Lys Glu Glu Ala Leu Val Leu Asp Thr Lys 
            260                 265                 270         


Lys Asp Leu Lys Gln Ile Thr Ser His Leu Leu Asp Met Leu Val Ser 
        275                 280                 285             


Lys Lys Val Ser Gly Gln Gly Arg Asp Gln Ala Leu Asn Leu Leu Asn 
    290                 295                 300                 


Lys Asn Val Pro Arg Lys Asp Leu Ala Ile His Asp Asn Ser Arg Thr 
305                 310                 315                 320 


Ile Tyr Val Val Asp Asn Gly Leu Arg Lys Ile Leu Lys Val Val Gly 
                325                 330                 335     


Gln Val Pro Asp Leu Pro Ser Cys Leu Pro Leu Thr Asp Asn Thr Arg 
            340                 345                 350         


Met Leu Ala Ser Ile Leu Ile Asn Lys Leu Tyr Asp Asp Leu Arg Cys 
        355                 360                 365             


Asp Pro Glu Arg Asp His Phe Arg Lys Ile Cys Glu Glu Tyr Ile Thr 
    370                 375                 380                 


Gly Lys Phe Asp Pro Gln Asp Met Asp Lys Asn Leu Asn Ala Ile Gln 
385                 390                 395                 400 


Thr Val Ser Gly Ile Leu Gln Gly Pro Phe Asp Leu Gly Asn Gln Leu 
                405                 410                 415     


Leu Gly Leu Lys Gly Val Met Glu Met Met Val Ala Leu Cys Gly Ser 
            420                 425                 430         


Glu Arg Glu Thr Asp Gln Leu Val Ala Val Glu Ala Leu Ile His Ala 
        435                 440                 445             


Ser Thr Lys Leu Ser Arg Ala Thr Phe Ile Ile Thr Asn Gly Val Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ile Tyr Lys Thr Thr Lys Asn Glu Lys Ile Lys Ile 
465                 470                 475                 480 


Arg Thr Leu Val Thr Ser Asp Lys Thr Ile Leu Tyr Ser Val Ala Thr 
                485                 490                 495     


Thr Leu Val Asn Cys Thr Asn Ser Tyr Asp Val Lys Glu Val Ile Pro 
            500                 505                 510         


Glu Leu Val Gln Leu Ala Lys Phe Ser Lys Gln His Val Pro Glu Glu 
        515                 520                 525             


His Pro Lys Asp Lys Lys Asp Phe Ile Asp Met Arg Val Lys Arg Leu 
    530                 535                 540                 


Leu Lys Ala Gly Val Ile Ser Ala Leu Ala Cys Met Val Lys Ala Asp 
545                 550                 555                 560 


Ser Ala Ile Leu Thr Asp Gln Thr Lys Glu Leu Leu Ala Arg Val Phe 
                565                 570                 575     


Leu Ala Leu Cys Asp Asn Pro Lys Asp Arg Gly Thr Ile Val Ala Gln 
            580                 585                 590         


Gly Gly Gly Lys Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp Val 
        595                 600                 605             


Gly Lys Val Lys Ala Ala His Ala Leu Ala Lys Ile Ala Ala Val Ser 
    610                 615                 620                 


Asn Pro Asp Ile Ala Phe Pro Gly Glu Arg Val Tyr Glu Val Val Arg 
625                 630                 635                 640 


Pro Leu Val Arg Leu Leu Asp Thr Gln Arg Asp Gly Leu Gln Asn Tyr 
                645                 650                 655     


Glu Ala Leu Leu Gly Leu Thr Asn Leu Ser Gly Arg Ser Asp Lys Leu 
            660                 665                 670         


Arg Gln Lys Ile Phe Lys Glu Arg Ala Leu Pro Asp Ile Glu Asn Tyr 
        675                 680                 685             


Met Phe Glu Asn His Asp Gln Leu Arg Gln Ala Ala Thr Glu Cys Met 
    690                 695                 700                 


Cys Asn Met Val Leu His Lys Glu Val Gln Glu Arg Phe Leu Ala Asp 
705                 710                 715                 720 


Gly Asn Asp Arg Leu Lys Leu Val Val Leu Leu Cys Gly Glu Asp Asp 
                725                 730                 735     


Asp Lys Val Gln Asn Ala Ala Ala Gly Ala Leu Ala Met Leu Thr Ala 
            740                 745                 750         


Ala His Lys Lys Leu Cys Leu Lys Met Thr Gln Val Thr Thr Gln Trp 
        755                 760                 765             


Leu Glu Ile Leu Gln Arg Leu Cys Leu His Asp Gln Leu Ser Val Gln 
    770                 775                 780                 


His Arg Gly Leu Val Ile Ala Tyr Asn Leu Leu Ala Ala Asp Ala Glu 
785                 790                 795                 800 


Leu Ala Lys Lys Leu Val Glu Ser Glu Leu Leu Glu Ile Leu Thr Val 
                805                 810                 815     


Val Gly Lys Gln Glu Pro Asp Glu Lys Lys Ala Glu Val Val Gln Thr 
            820                 825                 830         


Ala Arg Glu Cys Leu Ile Lys Cys Met Asp Tyr Gly Phe Ile Lys Pro 
        835                 840                 845             


Val Ser 
    850 


<210> 6552
<211> 183
<212> PRT
<213> Homo sapiens

<400> 6552
Met Met Gln Ile Cys Asp Thr Tyr Asn Gln Lys His Ser Leu Phe Asn 
1               5                   10                  15      


Ala Met Asn Arg Phe Ile Gly Ala Val Asn Asn Met Asp Gln Thr Val 
            20                  25                  30          


Met Val Pro Ser Leu Leu Arg Asp Val Pro Leu Ala Asp Pro Gly Leu 
        35                  40                  45              


Asp Asn Asp Val Gly Val Glu Val Gly Gly Ser Gly Gly Cys Leu Glu 
    50                  55                  60                  


Glu Arg Thr Pro Pro Val Pro Asp Ser Gly Ser Ala Asn Gly Ser Phe 
65                  70                  75                  80  


Phe Ala Pro Ser Arg Asp Met Tyr Ser His Tyr Val Leu Leu Lys Ser 
                85                  90                  95      


Ile Arg Asn Asp Ile Glu Trp Gly Val Leu His Gln Pro Pro Pro Pro 
            100                 105                 110         


Ala Gly Ser Glu Glu Gly Ser Ala Trp Lys Ser Lys Asp Ile Leu Val 
        115                 120                 125             


Asp Leu Gly His Leu Glu Gly Ala Asp Ala Gly Glu Glu Asp Leu Glu 
    130                 135                 140                 


Gln Gln Phe His Tyr His Leu Arg Gly Leu His Thr Val Leu Ser Lys 
145                 150                 155                 160 


Leu Thr Arg Lys Ala Asn Ile Leu Thr Asn Arg Tyr Lys Gln Glu Ile 
                165                 170                 175     


Gly Phe Gly Asn Trp Gly His 
            180             


<210> 6553
<211> 121
<212> PRT
<213> Homo sapiens

<400> 6553
Met Phe Asn Lys Cys Ser Phe His Ser Ser Ile Tyr Arg Pro Ala Ala 
1               5                   10                  15      


Asp Asn Ser Ala Ser Ser Leu Cys Ala Ile Ile Cys Phe Leu Asn Leu 
            20                  25                  30          


Val Ile Glu Cys Asp Leu Glu Thr Asn Ser Glu Ile Asn Lys Leu Ile 
        35                  40                  45              


Ile Tyr Leu Phe Ser Gln Asn Asn Arg Ile Arg Phe Ser Lys Leu Leu 
    50                  55                  60                  


Leu Lys Ile Leu Phe Tyr Ile Ser Ile Phe Ser Tyr Pro Glu Leu Met 
65                  70                  75                  80  


Cys Glu Gln Tyr Val Thr Phe Ile Lys Pro Gly Ile His Tyr Gly Gln 
                85                  90                  95      


Val Ser Lys Lys His Ile Ile Tyr Ser Thr Phe Leu Ser Lys Asn Phe 
            100                 105                 110         


Lys Phe Gln Leu Leu Arg Val Cys Trp 
        115                 120     


<210> 6554
<211> 323
<212> PRT
<213> Homo sapiens

<400> 6554
Met Glu Ser Arg Val Ala Asp Ala Gly Thr Gly Glu Thr Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Thr Thr Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Thr Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Thr Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Thr Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Thr Ser Phe Asp Asn Thr Gly Asn Val Cys Ile Trp 
        115                 120                 125             


Pro Ser Glu Glu Val Leu Ala Tyr Tyr Cys Leu Lys His Asn Asn Ile 
    130                 135                 140                 


Phe Arg Ala Leu Ala Val Cys Glu Leu Gly Gly Gly Met Thr Cys Leu 
145                 150                 155                 160 


Ala Gly Leu Met Val Ala Ile Ser Ala Asp Val Lys Glu Val Leu Leu 
                165                 170                 175     


Thr Asp Gly Asn Glu Lys Ala Ile Arg Asn Val Gln Asp Ile Ile Thr 
            180                 185                 190         


Arg Asn Gln Lys Ala Gly Val Phe Lys Thr Gln Lys Ile Ser Ser Cys 
        195                 200                 205             


Val Leu Arg Trp Asp Asn Glu Thr Asp Val Ser Gln Leu Glu Gly His 
    210                 215                 220                 


Phe Asp Ile Val Met Cys Ala Asp Cys Leu Phe Leu Asp Gln Tyr Arg 
225                 230                 235                 240 


Ala Ser Leu Val Asp Ala Ile Lys Arg Leu Leu Gln Pro Arg Gly Lys 
                245                 250                 255     


Ala Met Val Phe Ala Pro Arg Arg Gly Asn Thr Leu Asn Gln Phe Cys 
            260                 265                 270         


Asn Leu Ala Glu Lys Ala Gly Phe Cys Ile Gln Arg His Glu Asn Tyr 
        275                 280                 285             


Asp Glu His Ile Ser Asn Phe His Ser Lys Leu Lys Lys Glu Asn Pro 
    290                 295                 300                 


Asp Ile Tyr Glu Glu Asn Leu His Tyr Pro Leu Leu Leu Ile Leu Thr 
305                 310                 315                 320 


Lys His Gly 
            


<210> 6555
<211> 1039
<212> PRT
<213> Homo sapiens

<400> 6555
Met Ala Val Gln Leu Val Pro Asp Ser Ala Leu Gly Leu Leu Met Met 
1               5                   10                  15      


Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys Leu 
            20                  25                  30          


Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp Leu 
        35                  40                  45              


Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Ala 
    50                  55                  60                  


Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg Arg 
65                  70                  75                  80  


Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu Tyr 
                85                  90                  95      


Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp Asn 
            100                 105                 110         


Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr Lys 
        115                 120                 125             


Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser Tyr 
    130                 135                 140                 


Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val Arg 
145                 150                 155                 160 


Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys Glu 
                165                 170                 175     


His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr Lys 
            180                 185                 190         


Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met Ser 
        195                 200                 205             


Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val Lys 
    210                 215                 220                 


Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly Ile 
225                 230                 235                 240 


Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe Gln 
                245                 250                 255     


Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser Val 
            260                 265                 270         


Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe Gly 
        275                 280                 285             


His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu Ile 
    290                 295                 300                 


Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp 
305                 310                 315                 320 


Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser Glu 
                325                 330                 335     


Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys Leu 
            340                 345                 350         


Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly Ser 
        355                 360                 365             


Leu Leu Ser Ser Gly Ser Gln Glu Ser Asp Ser Ser Gln Ser Ala Lys 
    370                 375                 380                 


Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gln Glu Ala Leu Glu Glu 
385                 390                 395                 400 


Thr Leu Arg Gln Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu Arg Glu 
                405                 410                 415     


Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro Leu Asp Pro Gly 
            420                 425                 430         


Glu Glu Pro Pro Ile Val Arg Arg Arg Ile Gly Thr Ala Phe Lys Leu 
        435                 440                 445             


Asp Glu Gln Lys Ile Leu Pro Lys Gly Glu Glu Ala Glu Leu Glu Arg 
    450                 455                 460                 


Leu Glu Arg Glu Phe Ala Ile Gln Ser Gln Ile Thr Glu Ala Ala Arg 
465                 470                 475                 480 


Arg Leu Ala Ser Asp Pro Asn Val Ser Lys Lys Leu Lys Lys Gln Arg 
                485                 490                 495     


Lys Thr Ser Tyr Leu Asn Ala Leu Lys Lys Leu Gln Glu Ile Glu Asn 
            500                 505                 510         


Ala Ile Asn Glu Asn Arg Ile Lys Ser Gly Lys Lys Pro Thr Gln Arg 
        515                 520                 525             


Ala Ser Leu Ile Ile Asp Asp Gly Asn Ile Ala Ser Glu Asp Ser Ser 
    530                 535                 540                 


Leu Ser Asp Ala Leu Val Leu Glu Asp Glu Asp Ser Gln Val Thr Ser 
545                 550                 555                 560 


Thr Ile Ser Pro Leu His Ser Pro His Lys Gly Leu Pro Pro Arg Pro 
                565                 570                 575     


Pro Ser His Asn Arg Pro Pro Pro Pro Gln Ser Leu Glu Gly Leu Arg 
            580                 585                 590         


Gln Met His Tyr His Arg Asn Asp Tyr Asp Lys Ser Pro Ile Lys Pro 
        595                 600                 605             


Lys Met Trp Ser Glu Ser Ser Leu Asp Glu Pro Tyr Glu Lys Val Lys 
    610                 615                 620                 


Lys Arg Ser Ser His Ser His Ser Ser Ser His Lys Arg Phe Pro Ser 
625                 630                 635                 640 


Thr Gly Ser Cys Ala Glu Ala Gly Gly Gly Ser Asn Ser Leu Gln Asn 
                645                 650                 655     


Ser Pro Ile Arg Gly Leu Pro His Trp Asn Ser Gln Ser Ser Met Pro 
            660                 665                 670         


Ser Thr Pro Asp Leu Arg Val Arg Ser Pro His Tyr Val His Ser Thr 
        675                 680                 685             


Arg Ser Val Asp Ile Ser Pro Thr Arg Leu His Ser Leu Ala Leu His 
    690                 695                 700                 


Phe Arg His Arg Ser Ser Ser Leu Glu Ser Gln Gly Lys Leu Leu Gly 
705                 710                 715                 720 


Ser Glu Asn Asp Thr Gly Ser Pro Asp Phe Tyr Thr Pro Arg Thr Arg 
                725                 730                 735     


Ser Ser Asn Gly Ser Asp Pro Met Asp Asp Cys Ser Ser Cys Thr Ser 
            740                 745                 750         


His Ser Ser Ser Glu His Tyr Tyr Pro Ala Gln Met Asn Ala Asn Tyr 
        755                 760                 765             


Ser Thr Leu Ala Glu Asp Ser Pro Ser Lys Ala Arg Gln Arg Gln Arg 
    770                 775                 780                 


Gln Arg Gln Arg Ala Ala Gly Ala Leu Gly Ser Ala Ser Ser Gly Ser 
785                 790                 795                 800 


Met Pro Asn Leu Ala Ala Arg Gly Gly Ala Gly Gly Ala Gly Gly Ala 
                805                 810                 815     


Gly Gly Gly Val Tyr Leu His Ser Gln Ser Gln Pro Ser Ser Gln Tyr 
            820                 825                 830         


Arg Ile Lys Glu Tyr Pro Leu Tyr Ile Glu Gly Gly Ala Thr Pro Val 
        835                 840                 845             


Val Val Arg Ser Leu Glu Ser Asp Gln Glu Gly His Tyr Ser Val Lys 
    850                 855                 860                 


Ala Gln Phe Lys Thr Ser Asn Ser Tyr Thr Ala Gly Gly Leu Phe Lys 
865                 870                 875                 880 


Glu Ser Trp Arg Gly Gly Gly Gly Asp Glu Gly Asp Thr Gly Arg Leu 
                885                 890                 895     


Thr Pro Ser Arg Ser Gln Ile Leu Arg Thr Pro Ser Leu Gly Arg Glu 
            900                 905                 910         


Gly Ala His Asp Lys Gly Ala Gly Arg Ala Ala Val Ser Asp Glu Leu 
        915                 920                 925             


Arg Gln Trp Tyr Gln Arg Ser Thr Ala Ser His Lys Glu His Ser Arg 
    930                 935                 940                 


Leu Ser His Thr Ser Ser Thr Ser Ser Asp Ser Gly Ser Gln Tyr Ser 
945                 950                 955                 960 


Thr Ser Ser Gln Ser Thr Phe Val Ala His Ser Arg Val Thr Arg Met 
                965                 970                 975     


Pro Gln Met Cys Lys Ala Thr Ser Ala Ala Leu Pro Gln Ser Gln Arg 
            980                 985                 990         


Ser Ser Thr Pro Ser Ser Glu Ile  Gly Ala Thr Pro Pro  Ser Ser Pro 
        995                 1000                 1005             


His His  Ile Leu Thr Trp Gln  Thr Gly Glu Ala Thr  Glu Asn Ser 
    1010                 1015                 1020             


Pro Ile  Leu Asp Gly Ser Glu  Ser Pro Pro His Gln  Ser Thr Asp 
    1025                 1030                 1035             


Glu 
    


<210> 6556
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6556
Met Tyr Arg Gln Arg Phe Leu Tyr Ser Leu Tyr Arg His Thr His Trp 
1               5                   10                  15      


Val Arg Cys Ala Lys Phe Ser Pro Asp Gly Arg Leu Ile Val Ser Cys 
            20                  25                  30          


Ser Glu Asp Lys Thr Ile Lys Ile Trp Asp Thr Thr Asn Lys Gln Cys 
        35                  40                  45              


Val Asn Asn Phe Ser Asp Ser Val Gly Asp Leu Ser Leu Leu Phe His 
    50                  55                  60                  


Phe Gln Lys Val Glu Ser Tyr Leu His Gln Glu Val Gln Thr His Arg 
65                  70                  75                  80  


Ser Tyr Tyr Gly Gly Leu Thr Leu Met Asn Cys Ile Val Lys Val Leu 
                85                  90                  95      


Pro Lys Glu Ile Ser Lys Asp Tyr Ile Leu Ile His His His Ile Phe 
            100                 105                 110         


Leu Ile Ser Thr Gln Glu His His Ile Pro Met Arg Lys Lys Leu Arg 
        115                 120                 125             


Leu 
    


<210> 6557
<211> 725
<212> PRT
<213> Homo sapiens

<400> 6557
Met His Pro Glu Pro Ser Glu Pro Ala Thr Gly Gly Ala Ala Glu Leu 
1               5                   10                  15      


Asp Cys Ala Gln Glu Pro Gly Val Glu Glu Ser Ala Gly Asp His Gly 
            20                  25                  30          


Ser Ala Gly Arg Gly Gly Cys Lys Glu Glu Ile Asn Asp Pro Lys Glu 
        35                  40                  45              


Ile Cys Val Gly Ser Ser Asp Thr Ser Tyr His Ser Gln Gln Lys Gln 
    50                  55                  60                  


Ser Gly Asp Asn Gly Ser Gly Gly His Phe Ala His Pro Arg Glu Asp 
65                  70                  75                  80  


Arg Glu Asp Arg Gly Pro Arg Met Thr Lys Ser Ser Leu Gln Lys Leu 
                85                  90                  95      


Cys Lys Gln His Lys Leu Tyr Ile Thr Pro Ala Leu Asn Asp Thr Leu 
            100                 105                 110         


Tyr Leu His Phe Lys Gly Phe Asp Arg Ile Glu Asn Leu Glu Glu Tyr 
        115                 120                 125             


Thr Gly Leu Arg Cys Leu Trp Leu Gln Ser Asn Gly Ile Gln Lys Ile 
    130                 135                 140                 


Glu Asn Leu Glu Ala Gln Thr Glu Leu Arg Cys Leu Phe Leu Gln Met 
145                 150                 155                 160 


Asn Leu Leu Arg Lys Ile Glu Asn Leu Glu Pro Leu Gln Lys Leu Asp 
                165                 170                 175     


Ala Leu Asn Leu Ser Asn Asn Tyr Ile Lys Thr Ile Glu Asn Leu Ser 
            180                 185                 190         


Cys Leu Pro Val Leu Asn Thr Leu Gln Met Ala His Asn His Leu Glu 
        195                 200                 205             


Thr Val Glu Asp Ile Gln His Leu Gln Glu Cys Leu Arg Leu Cys Val 
    210                 215                 220                 


Leu Asp Leu Ser His Asn Lys Leu Ser Asp Pro Glu Ile Leu Ser Ile 
225                 230                 235                 240 


Leu Glu Ser Met Pro Asp Leu Arg Val Leu Asn Leu Met Gly Asn Pro 
                245                 250                 255     


Val Ile Arg Gln Ile Pro Asn Tyr Arg Arg Thr Val Thr Val Arg Leu 
            260                 265                 270         


Lys His Leu Thr Tyr Leu Asp Asp Arg Pro Val Phe Pro Lys Asp Arg 
        275                 280                 285             


Ala Cys Ala Glu Ala Trp Ala Arg Gly Gly Tyr Ala Ala Glu Lys Glu 
    290                 295                 300                 


Glu Arg Gln Gln Trp Glu Ser Arg Glu Arg Lys Lys Ile Thr Asp Ser 
305                 310                 315                 320 


Ile Glu Ala Leu Ala Met Ile Lys Gln Arg Ala Glu Glu Arg Lys Arg 
                325                 330                 335     


Gln Arg Glu Ser Gln Glu Arg Gly Glu Met Thr Ser Ser Asp Asp Gly 
            340                 345                 350         


Glu Asn Val Pro Ala Ser Ala Glu Gly Lys Glu Glu Pro Pro Gly Asp 
        355                 360                 365             


Arg Glu Thr Arg Gln Lys Met Glu Leu Phe Val Lys Glu Ser Phe Glu 
    370                 375                 380                 


Ala Lys Asp Glu Leu Cys Pro Glu Lys Pro Ser Gly Glu Glu Pro Pro 
385                 390                 395                 400 


Val Glu Ala Lys Arg Glu Asp Gly Gly Pro Glu Pro Glu Gly Thr Leu 
                405                 410                 415     


Pro Ala Glu Thr Leu Leu Leu Ser Ser Pro Val Glu Val Lys Gly Glu 
            420                 425                 430         


Asp Gly Asp Gly Glu Pro Glu Gly Thr Leu Pro Ala Glu Ala Pro Pro 
        435                 440                 445             


Pro Pro Pro Pro Val Glu Val Lys Gly Glu Asp Gly Asp Gln Glu Pro 
    450                 455                 460                 


Glu Gly Thr Leu Pro Ala Glu Thr Leu Leu Leu Ser Pro Pro Val Lys 
465                 470                 475                 480 


Val Lys Gly Glu Asp Gly Asp Arg Glu Pro Glu Gly Thr Leu Pro Ala 
                485                 490                 495     


Glu Ala Pro Pro Pro Pro Pro Leu Gly Ala Ala Arg Glu Glu Pro Thr 
            500                 505                 510         


Pro Gln Ala Val Ala Thr Glu Gly Val Phe Val Thr Glu Leu Asp Gly 
        515                 520                 525             


Thr Arg Thr Glu Asp Leu Glu Thr Ile Arg Leu Glu Thr Lys Glu Thr 
    530                 535                 540                 


Phe Cys Ile Asp Asp Leu Pro Asp Leu Glu Asp Asp Asp Glu Thr Gly 
545                 550                 555                 560 


Lys Ser Leu Glu Asp Gln Asn Met Cys Phe Pro Lys Ile Glu Val Ile 
                565                 570                 575     


Ser Ser Leu Ser Asp Asp Ser Asp Pro Glu Leu Asp Tyr Thr Ser Leu 
            580                 585                 590         


Pro Val Leu Glu Asn Leu Pro Thr Asp Thr Leu Ser Asn Ile Phe Ala 
        595                 600                 605             


Val Ser Lys Asp Thr Ser Lys Ala Ala Arg Val Pro Phe Thr Asp Ile 
    610                 615                 620                 


Phe Lys Lys Glu Ala Lys Arg Asp Leu Glu Ile Arg Lys Gln Asp Thr 
625                 630                 635                 640 


Lys Ser Pro Arg Pro Leu Ile Gln Glu Leu Ser Asp Glu Asp Pro Ser 
                645                 650                 655     


Gly Gln Leu Leu Met Pro Pro Thr Cys Gln Arg Asp Ala Ala Pro Leu 
            660                 665                 670         


Thr Ser Ser Gly Asp Arg Asp Ser Asp Phe Leu Ala Ala Ser Ser Pro 
        675                 680                 685             


Val Pro Thr Glu Ser Ala Ala Thr Pro Pro Glu Thr Cys Val Gly Val 
    690                 695                 700                 


Ala Gln Pro Ser Gln Ala Leu Pro Thr Trp Asp Leu Thr Ala Phe Pro 
705                 710                 715                 720 


Ala Pro Lys Ala Ser 
                725 


<210> 6558
<211> 318
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6558
Xaa Gly Ile Asn Gly Ser Glu Gly Asp Gly Ala Glu Ile Ala Glu Lys 
1               5                   10                  15      


Phe Val Phe Phe Ile Gly Ser Lys Asn Gly Gly Lys Thr Thr Ile Ile 
            20                  25                  30          


Leu Arg Cys Leu Asp Arg Asp Glu Pro Pro Lys Pro Thr Leu Ala Leu 
        35                  40                  45              


Glu Tyr Thr Tyr Gly Arg Arg Ala Lys Gly His Asn Thr Pro Lys Asp 
    50                  55                  60                  


Ile Ala His Phe Trp Glu Leu Gly Gly Gly Thr Ser Leu Leu Asp Leu 
65                  70                  75                  80  


Ile Ser Ile Pro Ile Thr Gly Asp Thr Leu Arg Thr Phe Ser Leu Val 
                85                  90                  95      


Leu Val Leu Asp Leu Ser Lys Pro Asn Asp Leu Trp Pro Thr Met Glu 
            100                 105                 110         


Asn Leu Leu Gln Ala Thr Lys Ser His Val Asp Lys Val Ile Met Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Ala Lys Ala Val Ser Glu Met Arg Gln Lys Ile 
    130                 135                 140                 


Trp Asn Asn Met Pro Lys Asp His Pro Asp His Glu Leu Ile Asp Pro 
145                 150                 155                 160 


Phe Pro Val Pro Leu Val Ile Ile Gly Ser Lys Tyr Asp Val Phe Gln 
                165                 170                 175     


Asp Phe Glu Ser Glu Lys Arg Lys Val Ile Cys Lys Thr Leu Arg Phe 
            180                 185                 190         


Val Ala His Tyr Tyr Gly Ala Ser Leu Met Phe Thr Ser Lys Ser Glu 
        195                 200                 205             


Ala Leu Leu Leu Lys Ile Arg Gly Val Ile Asn Gln Leu Ala Phe Gly 
    210                 215                 220                 


Ile Asp Lys Ser Lys Ser Ile Cys Val Asp Gln Asn Lys Pro Leu Phe 
225                 230                 235                 240 


Ile Thr Ala Gly Leu Asp Ser Phe Gly Gln Ile Gly Ser Pro Pro Val 
                245                 250                 255     


Pro Glu Asn Asp Ile Gly Lys Leu His Ala His Ser Pro Met Glu Leu 
            260                 265                 270         


Trp Lys Lys Val Tyr Glu Lys Leu Phe Pro Pro Lys Ser Ile Asn Thr 
        275                 280                 285             


Leu Lys Asp Ile Lys Asp Pro Ala Arg Asp Pro Gln Tyr Ala Glu Asn 
    290                 295                 300                 


Glu Val Asp Glu Met Arg Ile Gln Lys Asp Leu Val Leu Ser 
305                 310                 315             


<210> 6559
<211> 852
<212> PRT
<213> Homo sapiens

<400> 6559
Met Glu Ala Leu Gly Pro Gly Gly Asp Arg Ala Ser Pro Ala Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Asp Leu Trp His Leu Ser Met Arg Ala Asp Ser Ala 
            20                  25                  30          


Tyr Ser Ser Phe Ser Ala Ala Ser Gly Gly Pro Glu Pro Arg Thr Gln 
        35                  40                  45              


Ser Pro Gly Thr Asp Leu Leu Pro Tyr Leu Asp Trp Asp Tyr Val Arg 
    50                  55                  60                  


Val Val Trp Gly Gly Pro Gly Pro Ala Pro Pro Asp Ala Ala Leu Cys 
65                  70                  75                  80  


Thr Ser Pro Arg Pro Arg Pro Ala Val Ala Ala Arg Ser Gly Pro Gln 
                85                  90                  95      


Pro Thr Glu Val Pro Gly Thr Pro Gly Pro Leu Asn Arg Gln Ala Thr 
            100                 105                 110         


Pro Leu Leu Tyr Ala Leu Ala Ala Glu Ala Glu Ala Ala Ala Gln Ala 
        115                 120                 125             


Ala Glu Pro Pro Ser Pro Pro Ala Ser Arg Ala Ala Tyr Arg Gln Arg 
    130                 135                 140                 


Leu Gln Gly Ala Gln Arg Arg Val Leu Arg Glu Thr Ser Phe Gln Arg 
145                 150                 155                 160 


Lys Glu Leu Arg Met Ser Leu Pro Ala Arg Leu Arg Pro Thr Val Pro 
                165                 170                 175     


Ala Arg Pro Pro Ala Thr His Pro Arg Ser Ala Ser Leu Ser His Pro 
            180                 185                 190         


Gly Gly Glu Gly Glu Pro Ala Arg Ser Arg Ala Pro Ala Pro Gly Thr 
        195                 200                 205             


Ala Gly Arg Gly Pro Leu Ala Asn Gln Gln Arg Lys Trp Cys Phe Ser 
    210                 215                 220                 


Glu Pro Gly Lys Leu Asp Arg Val Gly Arg Gly Gly Gly Pro Ala Arg 
225                 230                 235                 240 


Glu Cys Leu Gly Glu Ala Cys Ser Ser Ser Gly Leu Pro Gly Pro Glu 
                245                 250                 255     


Pro Leu Glu Phe Gln His Pro Ala Leu Ala Lys Phe Glu Asp His Glu 
            260                 265                 270         


Val Gly Trp Leu Pro Glu Thr Gln Pro Gln Gly Ser Met Asn Leu Asp 
        275                 280                 285             


Ser Gly Ser Leu Lys Leu Gly Asp Ala Phe Arg Pro Ala Ser Arg Ser 
    290                 295                 300                 


Arg Ser Ala Ser Gly Glu Val Leu Gly Ser Trp Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Thr Ile Pro Ile Val Gln Ala Val Pro Gln Gly Ala Glu Thr Pro Arg 
                325                 330                 335     


Pro Leu Phe Gln Thr Lys Leu Ser Arg Phe Leu Pro Gln Lys Glu Ala 
            340                 345                 350         


Ala Val Met Tyr Pro Ala Glu Leu Pro Gln Ser Ser Pro Ala Asp Ser 
        355                 360                 365             


Glu Gln Arg Val Ser Glu Thr Cys Ile Val Pro Ala Trp Leu Pro Ser 
    370                 375                 380                 


Leu Pro Asp Glu Val Phe Leu Glu Glu Ala Pro Leu Val Arg Met Arg 
385                 390                 395                 400 


Ser Pro Pro Asp Pro His Ala Ser Gln Gly Pro Pro Ala Ser Val His 
                405                 410                 415     


Ala Ser Asp Gln Pro Tyr Gly Thr Gly Leu Gly Gln Arg Thr Gly Gln 
            420                 425                 430         


Val Thr Val Pro Thr Glu Tyr Pro Leu His Glu Cys Pro Gly Thr Ala 
        435                 440                 445             


Gly Ala Asp Asp Cys Trp Gln Gly Val Asn Gly Ser Val Gly Ile Ser 
    450                 455                 460                 


Arg Pro Thr Ser His Thr Pro Thr Gly Thr Ala Asn Asp Asn Ile Pro 
465                 470                 475                 480 


Thr Ile Asp Pro Thr Gly Leu Thr Thr Asn Pro Pro Thr Ala Ala Glu 
                485                 490                 495     


Ser Asp Leu Leu Lys Pro Val Pro Ala Asp Ala Leu Gly Leu Ser Gly 
            500                 505                 510         


Asn Asp Thr Pro Gly Pro Ser His Asn Thr Ala Leu Ala Arg Gly Thr 
        515                 520                 525             


Gly Gln Pro Gly Ser Arg Pro Thr Trp Pro Ser Gln Cys Leu Glu Glu 
    530                 535                 540                 


Leu Val Gln Glu Leu Ala Arg Leu Asp Pro Ser Leu Cys Asp Pro Leu 
545                 550                 555                 560 


Ala Ser Gln Pro Ser Pro Glu Pro Pro Leu Gly Leu Leu Asp Gly Leu 
                565                 570                 575     


Ile Pro Leu Ala Glu Val Arg Ala Ala Met Arg Pro Ala Cys Gly Glu 
            580                 585                 590         


Ala Gly Glu Glu Ala Ala Ser Thr Phe Glu Pro Gly Ser Tyr Gln Phe 
        595                 600                 605             


Ser Phe Thr Gln Leu Leu Pro Ala Pro Arg Glu Glu Thr Arg Leu Glu 
    610                 615                 620                 


Asn Pro Ala Thr His Pro Val Leu Asp Gln Pro Cys Gly Gln Gly Leu 
625                 630                 635                 640 


Pro Ala Pro Asn Asn Ser Ile Gln Gly Lys Lys Val Glu Leu Ala Ala 
                645                 650                 655     


Arg Leu Gln Lys Met Leu Gln Asp Leu His Thr Glu Gln Glu Arg Leu 
            660                 665                 670         


Gln Gly Glu Ala Gln Ala Trp Ala Arg Arg Gln Ala Ala Leu Glu Ala 
        675                 680                 685             


Ala Val Arg Gln Ala Cys Ala Pro Gln Glu Leu Glu Arg Phe Ser Arg 
    690                 695                 700                 


Phe Met Ala Asp Leu Glu Arg Val Leu Gly Leu Leu Leu Leu Leu Gly 
705                 710                 715                 720 


Ser Arg Leu Ala Arg Val Arg Arg Ala Leu Ala Arg Ala Ala Ser Asp 
                725                 730                 735     


Ser Asp Pro Asp Glu Gln Ala Ser Leu Leu Gln Arg Leu Arg Leu Leu 
            740                 745                 750         


Gln Arg Gln Glu Glu Asp Ala Lys Glu Leu Lys Glu His Val Ala Arg 
        755                 760                 765             


Arg Glu Arg Ala Val Arg Glu Val Leu Val Arg Ala Leu Pro Val Glu 
    770                 775                 780                 


Glu Leu Arg Val Tyr Cys Ala Leu Leu Ala Gly Lys Ala Ala Val Leu 
785                 790                 795                 800 


Ala Gln Gln Arg Asn Leu Asp Glu Arg Ile Arg Leu Leu Gln Asp Gln 
                805                 810                 815     


Leu Asp Ala Ile Arg Asp Asp Leu Gly His His Ala Pro Ser Pro Ser 
            820                 825                 830         


Pro Ala Arg Pro Pro Gly Thr Cys Pro Pro Val Gln Pro Pro Phe Pro 
        835                 840                 845             


Leu Leu Leu Thr 
    850         


<210> 6560
<211> 591
<212> PRT
<213> Homo sapiens

<400> 6560
Met Ala Gln Gly Ser Val Ser Phe Asn Asp Val Thr Val Asp Phe Thr 
1               5                   10                  15      


Gln Glu Glu Trp Gln His Leu Asp His Ala Gln Lys Thr Leu Tyr Met 
            20                  25                  30          


Asp Val Met Leu Glu Asn Tyr Cys His Leu Ile Ser Val Gly Cys His 
        35                  40                  45              


Met Thr Lys Pro Asp Val Ile Leu Lys Leu Glu Arg Gly Glu Glu Pro 
    50                  55                  60                  


Trp Thr Ser Phe Ala Gly His Thr Cys Leu Glu Glu Asn Trp Lys Ala 
65                  70                  75                  80  


Glu Asp Phe Leu Val Lys Phe Lys Glu His Gln Glu Lys Tyr Ser Arg 
                85                  90                  95      


Ser Val Val Ser Ile Asn His Lys Lys Leu Val Lys Glu Lys Ser Lys 
            100                 105                 110         


Ile Tyr Glu Lys Thr Phe Thr Leu Gly Lys Asn Pro Val Asn Ser Lys 
        115                 120                 125             


Asn Leu Pro Pro Glu Tyr Asp Thr His Gly Arg Ile Leu Lys Asn Val 
    130                 135                 140                 


Ser Glu Leu Ile Ile Ser Asn Leu Asn Pro Ala Arg Lys Arg Leu Ser 
145                 150                 155                 160 


Glu Tyr Asn Gly Tyr Gly Lys Ser Leu Leu Ser Thr Lys Gln Glu Thr 
                165                 170                 175     


Thr His Pro Glu Val Lys Ser His Asn Gln Ser Ala Arg Ala Phe Ser 
            180                 185                 190         


His Asn Glu Val Leu Met Gln Tyr Gln Lys Thr Glu Thr Pro Ala Gln 
        195                 200                 205             


Ser Phe Gly Tyr Asn Asp Cys Glu Lys Ser Phe Leu Gln Arg Gly Gly 
    210                 215                 220                 


Leu Ile Thr His Ser Arg Pro Tyr Lys Gly Glu Asn Pro Ser Val Tyr 
225                 230                 235                 240 


Asn Lys Lys Arg Arg Ala Thr Asn Ile Glu Lys Lys His Thr Cys Asn 
                245                 250                 255     


Glu Cys Gly Lys Ser Phe Cys Arg Lys Ser Val Leu Ile Leu His Gln 
            260                 265                 270         


Gly Ile His Ser Glu Glu Lys Pro Tyr Gln Cys His Gln Cys Gly Asn 
        275                 280                 285             


Ala Phe Arg Arg Lys Ser Tyr Leu Ile Asp His Gln Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Tyr Glu Cys Asn Asp Cys Gly Lys Ser Phe Arg Gln 
305                 310                 315                 320 


Lys Thr Thr Leu Ser Leu His Gln Arg Ile His Thr Gly Glu Lys Pro 
                325                 330                 335     


Tyr Ile Cys Lys Glu Cys Gly Lys Ser Phe His Gln Lys Ala Asn Leu 
            340                 345                 350         


Thr Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ile Cys Asn 
        355                 360                 365             


Glu Cys Gly Lys Ser Phe Ser Gln Lys Thr Thr Leu Ala Leu His Glu 
    370                 375                 380                 


Lys Thr His Asn Glu Glu Lys Pro Tyr Ile Cys Ser Glu Cys Gly Lys 
385                 390                 395                 400 


Ser Phe Arg Gln Lys Thr Thr Leu Val Ala His Gln Arg Thr His Thr 
                405                 410                 415     


Gly Glu Lys Ser Tyr Glu Cys Pro His Cys Gly Lys Ala Phe Arg Met 
            420                 425                 430         


Lys Ser Tyr Leu Ile Asp His His Arg Thr His Thr Gly Glu Lys Pro 
        435                 440                 445             


Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe Ser Gln Lys Thr Asn Leu 
    450                 455                 460                 


Asn Leu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Asn 
465                 470                 475                 480 


Glu Cys Gly Lys Ser Phe Arg Gln Lys Ala Thr Leu Thr Val His Gln 
                485                 490                 495     


Lys Ile His Thr Gly Gln Lys Ser Tyr Glu Cys Pro Gln Cys Gly Lys 
            500                 505                 510         


Ala Phe Ser Arg Lys Ser Tyr Leu Ile His His Gln Arg Thr His Thr 
        515                 520                 525             


Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Cys Phe Arg Gln 
    530                 535                 540                 


Lys Thr Asn Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro 
545                 550                 555                 560 


Tyr Val Cys Asn Glu Cys Gly Lys Ser Phe Ser Tyr Lys Arg Asn Leu 
                565                 570                 575     


Ile Val His Gln Arg Thr His Lys Gly Glu Asn Ile Glu Met Gln 
            580                 585                 590     


<210> 6561
<211> 977
<212> PRT
<213> Homo sapiens

<400> 6561
Met Gly Trp Lys Pro Ser Glu Ala Arg Gly Gln Ser Gln Ser Phe Gln 
1               5                   10                  15      


Ala Ser Gly Leu Gln Pro Arg Ser Leu Lys Ala Ala Arg Arg Ala Thr 
            20                  25                  30          


Gly Arg Pro Asp Arg Ser Arg Ala Ala Arg Pro Thr Met Asp Pro Ser 
        35                  40                  45              


Ala His Arg Ser Arg Ala Ala Pro Pro Asn Met Asp Pro Asp Pro Gln 
    50                  55                  60                  


Ala Gly Val Gln Val Gly Met Arg Val Val Arg Gly Val Asp Trp Lys 
65                  70                  75                  80  


Trp Gly Gln Gln Asp Gly Gly Glu Gly Gly Val Gly Thr Val Val Glu 
                85                  90                  95      


Leu Gly Arg His Gly Ser Pro Ser Thr Pro Asp Arg Thr Val Val Val 
            100                 105                 110         


Gln Trp Asp Gln Gly Thr Arg Thr Asn Tyr Arg Ala Gly Tyr Gln Gly 
        115                 120                 125             


Ala His Asp Leu Leu Leu Tyr Asp Asn Ala Gln Ile Gly Val Arg His 
    130                 135                 140                 


Pro Asn Ile Ile Cys Asp Cys Cys Lys Lys His Gly Leu Arg Gly Met 
145                 150                 155                 160 


Arg Trp Lys Cys Arg Val Cys Leu Asp Tyr Asp Leu Cys Thr Gln Cys 
                165                 170                 175     


Tyr Met His Asn Lys His Glu Leu Ala His Ala Phe Asp Arg Tyr Glu 
            180                 185                 190         


Thr Ala His Ser Arg Pro Val Thr Leu Ser Pro Arg Gln Gly Leu Pro 
        195                 200                 205             


Arg Ile Pro Leu Arg Gly Ile Phe Gln Gly Ala Lys Val Val Arg Gly 
    210                 215                 220                 


Pro Asp Trp Glu Trp Gly Ser Gln Asp Gly Gly Glu Gly Lys Pro Gly 
225                 230                 235                 240 


Arg Val Val Asp Ile Arg Gly Trp Asp Val Glu Thr Gly Arg Ser Val 
                245                 250                 255     


Ala Ser Val Thr Trp Ala Asp Gly Thr Thr Asn Val Tyr Arg Val Gly 
            260                 265                 270         


His Lys Gly Lys Val Asp Leu Lys Cys Val Gly Glu Ala Ala Gly Gly 
        275                 280                 285             


Phe Tyr Tyr Lys Asp His Leu Pro Arg Leu Gly Lys Pro Ala Glu Leu 
    290                 295                 300                 


Gln Arg Arg Val Ser Ala Asp Ser Gln Pro Phe Gln His Gly Asp Lys 
305                 310                 315                 320 


Val Lys Cys Leu Leu Asp Thr Asp Val Leu Arg Glu Met Gln Glu Gly 
                325                 330                 335     


His Gly Gly Trp Asn Pro Arg Met Ala Glu His His Ser Phe Trp Val 
            340                 345                 350         


Gly Asp Val Val Arg Val Ile Gly Asp Leu Asp Thr Val Lys Arg Leu 
        355                 360                 365             


Gln Ala Gly His Gly Glu Trp Thr Asp Asp Met Ala Pro Ala Leu Gly 
    370                 375                 380                 


Arg Val Gly Lys Val Val Lys Val Phe Gly Asp Gly Asn Leu Arg Val 
385                 390                 395                 400 


Ala Val Ala Gly Gln Arg Trp Thr Phe Ser Pro Ser Cys Leu Val Ala 
                405                 410                 415     


Tyr Arg Pro Glu Glu Asp Ala Asn Leu Asp Val Ala Glu Arg Ala Arg 
            420                 425                 430         


Glu Asn Lys Ser Ser Leu Ser Val Ala Leu Asp Lys Leu Arg Ala Gln 
        435                 440                 445             


Lys Ser Asp Pro Glu His Pro Gly Arg Leu Val Val Glu Val Ala Leu 
    450                 455                 460                 


Gly Asn Ala Ala Arg Ala Leu Asp Leu Leu Arg Arg Arg Pro Glu Gln 
465                 470                 475                 480 


Val Asp Thr Lys Asn Gln Gly Arg Thr Ala Leu Gln Val Ala Ala Tyr 
                485                 490                 495     


Leu Gly Gln Val Glu Leu Ile Arg Leu Leu Leu Gln Ala Arg Ala Gly 
            500                 505                 510         


Val Asp Leu Pro Asp Asp Glu Gly Asn Thr Ala Leu His Tyr Ala Ala 
        515                 520                 525             


Leu Gly Asn Gln Pro Glu Ala Thr Arg Val Leu Leu Ser Ala Gly Cys 
    530                 535                 540                 


Arg Ala Asp Ala Ile Asn Ser Thr Gln Ser Thr Ala Leu His Val Ala 
545                 550                 555                 560 


Val Gln Arg Gly Phe Leu Glu Val Val Arg Ala Leu Cys Glu Arg Gly 
                565                 570                 575     


Cys Asp Val Asn Leu Pro Asp Ala His Ser Asp Thr Pro Leu His Ser 
            580                 585                 590         


Ala Ile Ser Ala Gly Thr Gly Ala Ser Gly Ile Val Glu Val Leu Thr 
        595                 600                 605             


Glu Val Pro Asn Ile Asp Val Thr Ala Thr Asn Ser Gln Gly Phe Thr 
    610                 615                 620                 


Leu Leu His His Ala Ser Leu Lys Gly His Ala Leu Ala Val Arg Lys 
625                 630                 635                 640 


Ile Leu Ala Arg Ala Arg Gln Leu Val Asp Ala Lys Lys Glu Asp Gly 
                645                 650                 655     


Phe Thr Ala Leu His Leu Ala Ala Leu Asn Asn His Arg Glu Val Ala 
            660                 665                 670         


Gln Ile Leu Ile Arg Glu Gly Arg Cys Asp Val Asn Val Arg Asn Arg 
        675                 680                 685             


Lys Leu Gln Ser Pro Leu His Leu Ala Val Gln Gln Ala His Val Gly 
    690                 695                 700                 


Leu Val Pro Leu Leu Val Asp Ala Gly Cys Ser Val Asn Ala Glu Asp 
705                 710                 715                 720 


Glu Glu Gly Asp Thr Ala Leu His Val Ala Leu Gln Arg His Gln Leu 
                725                 730                 735     


Leu Pro Leu Val Ala Asp Gly Ala Gly Gly Asp Pro Gly Pro Leu Gln 
            740                 745                 750         


Leu Leu Ser Arg Leu Gln Ala Ser Gly Leu Pro Gly Ser Ala Glu Leu 
        755                 760                 765             


Thr Val Gly Ala Ala Val Ala Cys Phe Leu Ala Leu Glu Gly Ala Asp 
    770                 775                 780                 


Val Ser Tyr Thr Asn His Arg Gly Arg Ser Pro Leu Asp Leu Ala Ala 
785                 790                 795                 800 


Glu Gly Arg Val Leu Lys Ala Leu Gln Gly Cys Ala Gln Arg Phe Arg 
                805                 810                 815     


Glu Arg Gln Ala Gly Gly Gly Ala Ala Pro Gly Pro Arg Gln Thr Leu 
            820                 825                 830         


Gly Thr Pro Asn Thr Val Thr Asn Leu His Val Gly Ala Ala Pro Gly 
        835                 840                 845             


Pro Glu Ala Ala Glu Cys Leu Val Cys Ser Glu Leu Ala Leu Leu Val 
    850                 855                 860                 


Leu Phe Ser Pro Cys Gln His Arg Thr Val Cys Glu Glu Cys Ala Arg 
865                 870                 875                 880 


Arg Met Lys Lys Cys Ile Arg Cys Gln Val Val Val Ser Lys Lys Leu 
                885                 890                 895     


Arg Pro Asp Gly Ser Glu Val Ala Ser Ala Ala Pro Ala Pro Gly Pro 
            900                 905                 910         


Pro Arg Gln Leu Val Glu Glu Leu Gln Ser Arg Tyr Arg Gln Met Glu 
        915                 920                 925             


Glu Arg Ile Thr Cys Pro Ile Cys Ile Asp Ser His Ile Arg Leu Val 
    930                 935                 940                 


Phe Gln Cys Gly His Gly Ala Cys Ala Pro Cys Gly Ser Ala Leu Ser 
945                 950                 955                 960 


Ala Cys Pro Ile Cys Arg Gln Pro Ile Arg Asp Arg Ile Gln Ile Phe 
                965                 970                 975     


Val 
    


<210> 6562
<211> 753
<212> PRT
<213> Homo sapiens

<400> 6562
Met Asp Pro Asp Pro Gln Ala Gly Val Gln Val Gly Met Arg Val Val 
1               5                   10                  15      


Arg Gly Val Asp Trp Lys Trp Gly Gln Gln Asp Gly Gly Glu Gly Gly 
            20                  25                  30          


Val Gly Thr Val Val Glu Leu Gly Arg His Gly Ser Pro Ser Thr Pro 
        35                  40                  45              


Asp Arg Thr Val Val Val Gln Trp Asp Gln Gly Thr Arg Thr Asn Tyr 
    50                  55                  60                  


Arg Ala Gly Tyr Gln Gly Ala His Asp Leu Leu Leu Tyr Asp Asn Ala 
65                  70                  75                  80  


Gln Ile Gly Val Arg His Pro Asn Ile Ile Cys Asp Cys Cys Lys Lys 
                85                  90                  95      


His Gly Leu Arg Gly Met Arg Trp Lys Cys Arg Val Cys Leu Asp Tyr 
            100                 105                 110         


Asp Leu Cys Thr Gln Cys Tyr Met His Asn Lys His Glu Leu Ala His 
        115                 120                 125             


Ala Phe Asp Arg Tyr Glu Thr Ala His Ser Arg Pro Val Thr Leu Ser 
    130                 135                 140                 


Pro Arg Gln Gly Leu Pro Arg Ile Pro Leu Arg Gly Ile Phe Gln Gly 
145                 150                 155                 160 


Ala Lys Val Val Arg Gly Pro Asp Trp Glu Trp Gly Ser Gln Asp Gly 
                165                 170                 175     


Lys Pro Ala Glu Leu Gln Arg Arg Val Ser Ala Asp Ser Gln Pro Phe 
            180                 185                 190         


Gln His Gly Asp Lys Val Lys Cys Leu Leu Asp Thr Asp Val Leu Arg 
        195                 200                 205             


Glu Met Gln Glu Gly His Gly Gly Trp Asn Pro Arg Met Ala Glu Phe 
    210                 215                 220                 


Ile Gly Gln Thr Gly Thr Val His Arg Ile Thr Asp Arg Gly Asp Val 
225                 230                 235                 240 


Arg Val Gln Phe Asn His Glu Thr Arg Trp Thr Phe His Pro Gly Ala 
                245                 250                 255     


Leu Thr Lys His His Ser Phe Trp Val Gly Asp Val Val Arg Val Ile 
            260                 265                 270         


Gly Asp Leu Asp Thr Val Lys Arg Leu Gln Ala Gly His Gly Glu Trp 
        275                 280                 285             


Thr Asp Asp Met Ala Pro Ala Leu Gly Arg Val Gly Lys Val Val Lys 
    290                 295                 300                 


Val Phe Gly Asp Gly Asn Leu Arg Val Ala Val Ala Gly Gln Arg Trp 
305                 310                 315                 320 


Thr Phe Ser Pro Ser Cys Leu Val Ala Tyr Arg Pro Glu Glu Asp Ala 
                325                 330                 335     


Asn Leu Asp Val Ala Glu Arg Ala Arg Glu Asn Lys Ser Ser Leu Ser 
            340                 345                 350         


Val Ala Leu Asp Lys Leu Arg Ala Gln Lys Ser Asp Pro Glu His Pro 
        355                 360                 365             


Gly Arg Leu Val Val Glu Val Ala Leu Gly Asn Ala Ala Arg Ala Leu 
    370                 375                 380                 


Asp Leu Leu Arg Arg Arg Pro Glu Gln Val Asp Thr Lys Asn Gln Gly 
385                 390                 395                 400 


Arg Thr Ala Leu Gln Val Ala Ala Tyr Leu Gly Gln Val Glu Leu Ile 
                405                 410                 415     


Arg Leu Leu Leu Gln Ala Arg Ala Gly Val Asp Leu Pro Asp Asp Glu 
            420                 425                 430         


Gly Asn Thr Ala Leu His Tyr Ala Ala Leu Gly Asn Gln Pro Glu Ala 
        435                 440                 445             


Thr Arg Val Leu Leu Ser Ala Gly Cys Arg Ala Asp Ala Ile Asn Ser 
    450                 455                 460                 


Thr Gln Ser Thr Ala Leu His Val Ala Val Gln Arg Gly Phe Leu Glu 
465                 470                 475                 480 


Val Val Arg Ala Leu Cys Glu Arg Gly Cys Asp Val Asn Leu Pro Asp 
                485                 490                 495     


Ala His Ser Asp Thr Pro Leu His Ser Ala Ile Ser Ala Gly Thr Gly 
            500                 505                 510         


Ala Ser Gly Ile Val Glu Val Leu Thr Glu Val Pro Asn Ile Asp Val 
        515                 520                 525             


Thr Ala Thr Asn Ser Gln Gly Phe Thr Leu Leu His His Ala Ser Leu 
    530                 535                 540                 


Lys Gly His Ala Leu Ala Val Arg Lys Ile Leu Ala Arg Ala Arg Gln 
545                 550                 555                 560 


Leu Val Asp Ala Lys Lys Glu Asp Gly Phe Thr Ala Leu His Leu Ala 
                565                 570                 575     


Ala Leu Asn Asn His Arg Glu Val Ala Gln Ile Leu Ile Arg Glu Gly 
            580                 585                 590         


Arg Cys Asp Val Asn Val Arg Asn Arg Lys Leu Gln Ser Pro Leu His 
        595                 600                 605             


Leu Ala Val Gln Gln Ala His Val Gly Leu Val Pro Leu Leu Val Asp 
    610                 615                 620                 


Ala Gly Cys Ser Val Asn Ala Glu Asp Glu Glu Gly Asp Thr Ala Leu 
625                 630                 635                 640 


His Val Ala Leu Gln Arg His Gln Leu Leu Pro Leu Val Ala Asp Gly 
                645                 650                 655     


Ala Gly Gly Asp Pro Gly Pro Leu Gln Leu Leu Ser Arg Leu Gln Ala 
            660                 665                 670         


Ser Gly Leu Pro Gly Ser Ala Glu Leu Thr Val Gly Ala Ala Val Ala 
        675                 680                 685             


Cys Phe Leu Ala Leu Glu Gly Ala Asp Val Ser Tyr Thr Asn His Arg 
    690                 695                 700                 


Gly Arg Ser Pro Leu Asp Leu Ala Ala Glu Gly Arg Val Leu Lys Ala 
705                 710                 715                 720 


Leu Gln Gly Cys Ala Gln Arg Phe Arg Val Arg Ala Gln Asp Glu Glu 
                725                 730                 735     


Val His Gln Val Pro Gly Gly Arg Gln Gln Glu Thr Ala Pro Arg Arg 
            740                 745                 750         


Leu 
    


<210> 6563
<211> 386
<212> PRT
<213> Homo sapiens

<400> 6563
Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
1               5                   10                  15      


Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly Leu Tyr 
    50                  55                  60                  


Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
            100                 105                 110         


Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
        115                 120                 125             


Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
    130                 135                 140                 


Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu Pro Leu 
145                 150                 155                 160 


Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu Leu Arg 
                165                 170                 175     


Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met Lys Ile 
            180                 185                 190         


Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr Glu Asp 
        195                 200                 205             


Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly Thr Lys 
    210                 215                 220                 


Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile Pro Ala 
225                 230                 235                 240 


Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe Arg Arg 
                245                 250                 255     


Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys Glu Ala 
            260                 265                 270         


Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg Val Ile 
        275                 280                 285             


Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys Arg Leu 
    290                 295                 300                 


Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg Gly Asp 
305                 310                 315                 320 


Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr Pro Gln 
                325                 330                 335     


Thr Arg Gln Ile Leu Lys Gln Gln Tyr Pro Gln His Ser Leu His Ser 
            340                 345                 350         


Met Cys Thr Gln Leu Asp Val His Trp Thr Leu Ala Thr Phe Ser Lys 
        355                 360                 365             


Met Gln Lys Lys Ala Thr Gly Phe Gln Glu Asn Val Pro Val Pro Asp 
    370                 375                 380                 


Pro Phe 
385     


<210> 6564
<211> 335
<212> PRT
<213> Homo sapiens

<400> 6564
Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg 
1               5                   10                  15      


Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu 
            20                  25                  30          


Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys 
        35                  40                  45              


Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr 
    50                  55                  60                  


Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu 
65                  70                  75                  80  


Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu 
                85                  90                  95      


Ala Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser 
            100                 105                 110         


Glu Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr 
        115                 120                 125             


Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val 
    130                 135                 140                 


Asn Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile 
145                 150                 155                 160 


Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro 
                165                 170                 175     


Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu 
            180                 185                 190         


Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly 
        195                 200                 205             


Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro 
    210                 215                 220                 


Asp Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser 
225                 230                 235                 240 


Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Val Asp Asp 
                245                 250                 255     


Ile Asn Ala Asp Lys Asn Ile Ser Ser Ala Gln Ile Val Gly Pro Gly 
            260                 265                 270         


Pro Lys Pro Glu Ala Ser Ala Lys Leu Pro Ser Arg Pro Ala Asp Asn 
        275                 280                 285             


Tyr Asp Asn Phe Val Leu Pro Glu Leu Pro Ser Val Pro Asp Thr Leu 
    290                 295                 300                 


Pro Thr Ala Ser Ala Gly Ala Ser Thr Ser Ala Ser Glu Asp Ile Asp 
305                 310                 315                 320 


Phe Asp Asp Leu Ser Arg Arg Phe Glu Glu Leu Lys Lys Lys Thr 
                325                 330                 335 


<210> 6565
<211> 366
<212> PRT
<213> Homo sapiens

<400> 6565
Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg 
1               5                   10                  15      


Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu 
            20                  25                  30          


Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys 
        35                  40                  45              


Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr 
    50                  55                  60                  


Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu 
65                  70                  75                  80  


Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu 
                85                  90                  95      


Ala Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser 
            100                 105                 110         


Glu Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr 
        115                 120                 125             


Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val 
    130                 135                 140                 


Asn Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile 
145                 150                 155                 160 


Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro 
                165                 170                 175     


Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu 
            180                 185                 190         


Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly 
        195                 200                 205             


Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro 
    210                 215                 220                 


Asp Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser 
225                 230                 235                 240 


Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp Phe 
                245                 250                 255     


Asn Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His Pro 
            260                 265                 270         


Pro Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu Ser Val Asp Asp Ile 
        275                 280                 285             


Asn Ala Asp Lys Asn Ile Ser Ser Ala Gln Ile Val Gly Pro Gly Pro 
    290                 295                 300                 


Lys Pro Glu Ala Ser Ala Lys Leu Pro Ser Arg Pro Ala Asp Asn Tyr 
305                 310                 315                 320 


Asp Asn Phe Val Leu Pro Glu Leu Pro Ser Val Pro Asp Thr Leu Pro 
                325                 330                 335     


Thr Ala Ser Ala Gly Ala Ser Thr Ser Ala Ser Glu Asp Ile Asp Phe 
            340                 345                 350         


Asp Asp Leu Ser Arg Arg Phe Glu Glu Leu Lys Lys Lys Thr 
        355                 360                 365     


<210> 6566
<211> 315
<212> PRT
<213> Homo sapiens

<400> 6566
Met Glu Lys Tyr Glu Lys Leu Ala Lys Thr Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Val Val Phe Lys Cys Arg Asn Lys Thr Ser Gly Gln Val Val Ala Val 
            20                  25                  30          


Lys Lys Phe Val Glu Ser Glu Asp Asp Pro Val Val Lys Lys Ile Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Met Leu Lys Gln Leu Lys His Pro Asn Leu Val 
    50                  55                  60                  


Asn Leu Ile Glu Val Phe Arg Arg Lys Arg Lys Met His Leu Val Phe 
65                  70                  75                  80  


Glu Tyr Cys Asp His Thr Leu Leu Asn Glu Leu Glu Arg Asn Pro Asn 
                85                  90                  95      


Gly Val Ala Asp Gly Val Ile Lys Ser Val Leu Trp Gln Thr Leu Gln 
            100                 105                 110         


Ala Leu Asn Phe Cys His Ile His Asn Cys Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Ile Thr Lys Gln Gly Ile Ile Lys Ile Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Gln Ile Leu Ile Pro Gly Asp Ala Tyr Thr Asp Tyr 
145                 150                 155                 160 


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp Thr 
                165                 170                 175     


Gln Tyr Gly Ser Ser Val Asp Ile Trp Ala Ile Gly Cys Val Phe Ala 
            180                 185                 190         


Glu Leu Leu Thr Gly Gln Pro Leu Trp Pro Gly Lys Ser Asp Val Asp 
        195                 200                 205             


Gln Leu Tyr Leu Ile Ile Arg Thr Leu Gly Lys Leu Ile Pro Arg His 
    210                 215                 220                 


Gln Ser Ile Phe Lys Ser Asn Gly Phe Phe His Gly Ile Ser Ile Pro 
225                 230                 235                 240 


Glu Pro Glu Asp Met Glu Thr Leu Glu Glu Lys Phe Ser Asp Val His 
                245                 250                 255     


Pro Val Ala Leu Asn Phe Met Lys Gly Cys Leu Lys Met Asn Pro Asp 
            260                 265                 270         


Asp Arg Leu Thr Cys Ser Gln Leu Leu Glu Ser Ser Tyr Phe Asp Ser 
        275                 280                 285             


Phe Gln Glu Ala Gln Ile Lys Arg Lys Ala Arg Asn Glu Gly Arg Asn 
    290                 295                 300                 


Arg Arg Arg Gln Gln Val Leu Pro Leu Lys Ser 
305                 310                 315 


<210> 6567
<211> 315
<212> PRT
<213> Homo sapiens

<400> 6567
Met Ala Asn Asp Pro Leu Glu Gly Phe His Glu Val Asn Leu Ala Ser 
1               5                   10                  15      


Pro Thr Ser Pro Asp Leu Leu Gly Val Tyr Glu Ser Gly Thr Gln Glu 
            20                  25                  30          


Gln Thr Thr Ser Pro Ser Val Ile Tyr Arg Pro His Pro Ser Ala Leu 
        35                  40                  45              


Ser Ser Val Pro Ile Gln Ala Asn Ala Leu Asp Val Ser Glu Leu Pro 
    50                  55                  60                  


Thr Gln Pro Val Tyr Ser Ser Pro Arg Arg Leu Asn Cys Ala Glu Ile 
65                  70                  75                  80  


Ser Ser Ile Ser Phe His Val Thr Asp Pro Ala Pro Cys Ser Thr Ser 
                85                  90                  95      


Gly Val Thr Ala Gly Leu Thr Lys Leu Thr Thr Arg Lys Asp Asn Tyr 
            100                 105                 110         


Asn Ala Glu Arg Glu Phe Leu Gln Gly Ala Thr Ile Thr Glu Ala Cys 
        115                 120                 125             


Asp Gly Ser Asp Asp Ile Phe Gly Leu Ser Thr Asp Ser Leu Ser Arg 
    130                 135                 140                 


Leu Arg Ser Pro Ser Val Leu Glu Val Arg Glu Lys Gly Tyr Glu Arg 
145                 150                 155                 160 


Leu Lys Glu Glu Leu Ala Lys Ala Gln Arg Glu Leu Lys Leu Lys Asp 
                165                 170                 175     


Glu Glu Cys Glu Arg Leu Ser Lys Val Arg Asp Gln Leu Gly Gln Glu 
            180                 185                 190         


Leu Glu Glu Leu Thr Ala Ser Leu Phe Glu Glu Ala His Lys Met Val 
        195                 200                 205             


Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu Lys Glu 
    210                 215                 220                 


Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala Leu Lys 
225                 230                 235                 240 


Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu Pro Leu 
                245                 250                 255     


Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn Lys Ser 
            260                 265                 270         


Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val Ile Gln 
        275                 280                 285             


Pro Ile Val Lys Asp Cys Lys Glu Val Thr His Gln Gly Leu Ser Pro 
    290                 295                 300                 


Leu Thr Leu Leu Ile Leu Val Ser Ser His His 
305                 310                 315 


<210> 6568
<211> 357
<212> PRT
<213> Homo sapiens

<400> 6568
Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210> 6569
<211> 385
<212> PRT
<213> Homo sapiens

<400> 6569
Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Leu Ala Pro Ser Thr 
            340                 345                 350         


Leu Cys Ser Phe Ile Ser Ser Ser Ser Gly Val Ser Gly Val Gly Ala 
        355                 360                 365             


Glu Arg Arg Pro Arg Pro Thr Thr Val Thr Ala Val His Ser Gly Ser 
    370                 375                 380                 


Lys 
385 


<210> 6570
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6570
Met Lys Lys Glu His Val Leu His Cys Gln Phe Ser Ala Trp Tyr Pro 
1               5                   10                  15      


Phe Phe Arg Gly Val Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
            20                  25                  30          


Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
        35                  40                  45              


Arg Asp Asp Pro Pro Thr His Ser Gln Pro Asp Ser Asp Asp Glu Ala 
    50                  55                  60                  


Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn Thr Ala Thr Leu Thr Ala 
65                  70                  75                  80  


Pro Glu Phe Pro Glu Phe Ala Thr Lys Val Gln Glu Ala Ile Asn Ser 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Pro Lys Leu Asn Trp Ser Ala Pro Arg Asp 
            100                 105                 110         


Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Thr Leu Ser 
        115                 120                 125             


Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr Arg Asp Phe 
    130                 135                 140                 


Thr Gln Pro Phe Ile His Cys Thr Asp Asp Ser Pro Asp Pro Cys Ile 
145                 150                 155                 160 


Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
                165                 170                 175     


Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Val Val Phe Asp 
            180                 185                 190         


Ile Tyr Arg Asp Ser Arg Gly Lys Val Trp Leu Ile Asp Phe Asn Pro 
        195                 200                 205             


Phe Gly Glu Val Thr Asp Ser Leu Leu Phe Thr Trp Glu Glu Leu Ile 
    210                 215                 220                 


Ser Glu Asn Asn Leu Asn Gly Asp Phe Ser Glu Val Asp Ala Gln Glu 
225                 230                 235                 240 


Gln Asp Ser Pro Ala Phe Arg Cys Thr Asn Ser Glu Val Thr Val Gln 
                245                 250                 255     


Pro Ser Pro Tyr Leu Ser Tyr Arg Leu Pro Lys Asp Phe Val Asp Leu 
            260                 265                 270         


Ser Thr Gly Glu Asp Ala His Lys Leu Ile Asp Phe Leu Lys Leu Lys 
        275                 280                 285             


Arg Asn Gln Gln Glu Asp Asp 
    290                 295 


<210> 6571
<211> 1090
<212> PRT
<213> Homo sapiens

<400> 6571
Met Glu Gln Pro Lys Gly Val Asp Trp Thr Val Ile Ile Leu Thr Cys 
1               5                   10                  15      


Gln Tyr Lys Asp Ser Val Gln Val Phe Gln Arg Glu Leu Glu Val Arg 
            20                  25                  30          


Gln Lys Arg Glu Gln Ile Pro Ala Gly Thr Leu Leu Leu Ala Val Glu 
        35                  40                  45              


Asp Pro Glu Lys Arg Val Gly Ser Gly Gly Ala Thr Leu Asn Ala Leu 
    50                  55                  60                  


Leu Val Ala Ala Glu His Leu Ser Ala Arg Ala Gly Phe Thr Trp Ile 
65                  70                  75                  80  


Cys Val Gly Val Ser Leu Trp Ile Arg Gly Cys His Pro Pro Gly Arg 
                85                  90                  95      


Leu Pro Glu Ala Ser Val His Arg Ala Phe Pro Leu Leu Gln Val Val 
            100                 105                 110         


Thr Ser Asp Val Leu His Ser Ala Trp Ile Leu Ile Leu His Met Gly 
        115                 120                 125             


Arg Asp Phe Pro Phe Asp Asp Cys Gly Arg Ala Phe Thr Cys Leu Pro 
    130                 135                 140                 


Val Glu Asn Pro Glu Ala Pro Val Glu Ala Leu Val Cys Asn Leu Asp 
145                 150                 155                 160 


Cys Leu Leu Asp Ile Met Thr Tyr Arg Leu Gly Pro Gly Ser Pro Pro 
                165                 170                 175     


Gly Val Trp Val Cys Ser Thr Asp Met Leu Leu Ser Val Pro Ala Asn 
            180                 185                 190         


Pro Gly Ile Ser Trp Asp Ser Phe Arg Gly Ala Arg Val Ile Ala Leu 
        195                 200                 205             


Pro Gly Ser Pro Ala Tyr Ala Gln Asn His Gly Val Tyr Leu Thr Asp 
    210                 215                 220                 


Pro Gln Gly Leu Val Leu Asp Ile Tyr Tyr Gln Gly Thr Glu Ala Glu 
225                 230                 235                 240 


Ile Gln Arg Cys Val Arg Pro Asp Gly Arg Val Pro Leu Val Ser Gly 
                245                 250                 255     


Val Val Phe Phe Ser Val Glu Thr Ala Glu Arg Leu Leu Ala Thr His 
            260                 265                 270         


Val Ser Pro Pro Leu Asp Ala Cys Thr Tyr Leu Gly Leu Asp Ser Gly 
        275                 280                 285             


Ala Arg Pro Val Gln Leu Ser Leu Phe Phe Asp Ile Leu His Cys Met 
    290                 295                 300                 


Ala Glu Asn Val Thr Arg Glu Asp Phe Leu Val Gly Arg Pro Pro Glu 
305                 310                 315                 320 


Leu Gly Gln Gly Asp Ala Asp Val Ala Gly Tyr Leu Gln Ser Ala Arg 
                325                 330                 335     


Ala Gln Leu Trp Arg Glu Leu Arg Asp Gln Pro Leu Thr Met Ala Tyr 
            340                 345                 350         


Val Ser Ser Gly Ser Tyr Ser Tyr Met Thr Ser Ser Ala Ser Glu Phe 
        355                 360                 365             


Leu Leu Ser Leu Thr Leu Pro Gly Ala Pro Gly Ala Gln Ile Val His 
    370                 375                 380                 


Ser Gln Val Glu Glu Gln Gln Leu Leu Ala Ala Gly Ser Ser Val Val 
385                 390                 395                 400 


Ser Cys Leu Leu Glu Gly Pro Val Gln Leu Gly Pro Gly Ser Val Leu 
                405                 410                 415     


Gln His Cys His Leu Gln Gly Pro Ile His Ile Gly Ala Gly Cys Leu 
            420                 425                 430         


Val Thr Gly Leu Asp Thr Ala His Ser Lys Ala Leu His Gly Arg Glu 
        435                 440                 445             


Leu Arg Asp Leu Val Leu Gln Gly His His Thr Arg Leu His Gly Ser 
    450                 455                 460                 


Pro Gly His Ala Phe Thr Leu Val Gly Arg Leu Asp Ser Trp Glu Arg 
465                 470                 475                 480 


Gln Gly Ala Gly Thr Tyr Leu Asn Val Pro Trp Ser Glu Phe Phe Lys 
                485                 490                 495     


Arg Thr Gly Val Arg Ala Trp Asp Leu Trp Asp Pro Glu Thr Leu Pro 
            500                 505                 510         


Ala Glu Tyr Cys Leu Pro Ser Ala Arg Leu Phe Pro Val Leu His Pro 
        515                 520                 525             


Ser Arg Glu Leu Gly Pro Gln Asp Leu Leu Trp Met Leu Asp His Gln 
    530                 535                 540                 


Glu Asp Gly Gly Glu Ala Leu Arg Ala Trp Arg Ala Ser Trp Arg Leu 
545                 550                 555                 560 


Ser Trp Glu Gln Leu Gln Pro Cys Leu Asp Arg Ala Ala Thr Leu Ala 
                565                 570                 575     


Ser Arg Arg Asp Leu Phe Phe Arg Gln Ala Leu His Lys Ala Arg His 
            580                 585                 590         


Val Leu Glu Ala Arg Gln Asp Leu Ser Leu Arg Pro Leu Ile Trp Ala 
        595                 600                 605             


Ala Val Arg Glu Gly Cys Pro Gly Pro Leu Leu Ala Thr Leu Asp Gln 
    610                 615                 620                 


Val Ala Ala Gly Ala Gly Asp Pro Gly Val Ala Ala Arg Ala Leu Ala 
625                 630                 635                 640 


Cys Val Ala Asp Val Leu Gly Cys Met Ala Glu Gly Arg Gly Gly Leu 
                645                 650                 655     


Arg Ser Gly Pro Ala Ala Asn Pro Glu Trp Met Arg Pro Phe Ser Tyr 
            660                 665                 670         


Leu Glu Cys Gly Asp Leu Ala Ala Gly Val Glu Ala Leu Ala Gln Glu 
        675                 680                 685             


Arg Asp Lys Trp Leu Ser Arg Pro Ala Leu Leu Val Arg Ala Ala Arg 
    690                 695                 700                 


His Tyr Glu Gly Ala Gly Gln Ile Leu Ile Arg Gln Ala Val Met Ser 
705                 710                 715                 720 


Ala Gln His Phe Val Ser Thr Glu Gln Val Glu Leu Pro Gly Pro Gly 
                725                 730                 735     


Gln Trp Val Val Ala Glu Cys Pro Ala Arg Val Asp Phe Ser Gly Gly 
            740                 745                 750         


Trp Ser Asp Thr Pro Pro Leu Ala Tyr Glu Leu Gly Gly Ala Val Leu 
        755                 760                 765             


Gly Leu Ala Val Arg Val Asp Gly Arg Arg Pro Ile Gly Ala Arg Ala 
    770                 775                 780                 


Arg Arg Ile Pro Glu Pro Glu Leu Trp Leu Ala Val Gly Pro Arg Gln 
785                 790                 795                 800 


Asp Glu Met Thr Val Lys Ile Val Cys Arg Cys Leu Ala Asp Leu Arg 
                805                 810                 815     


Asp Tyr Cys Gln Pro His Ala Pro Gly Ala Leu Leu Lys Ala Ala Phe 
            820                 825                 830         


Ile Cys Ala Gly Ile Val His Val His Ser Glu Leu Gln Leu Ser Thr 
        835                 840                 845             


Ser Ser Ile Leu Ala Gly Thr Ala Leu Ala Ala Leu Gln Arg Ala Ala 
    850                 855                 860                 


Gly Arg Val Val Gly Thr Glu Ala Leu Ile His Ala Val Leu His Leu 
865                 870                 875                 880 


Glu Gln Val Leu Thr Thr Gly Gly Gly Trp Gln Asp Gln Val Gly Gly 
                885                 890                 895     


Leu Met Pro Gly Ile Lys Val Gly Arg Ser Arg Ala Gln Leu Pro Leu 
            900                 905                 910         


Lys Val Glu Val Glu Glu Val Thr Val Pro Glu Gly Phe Val Gln Lys 
        915                 920                 925             


Leu Asn Asp His Leu Leu Leu Val Tyr Thr Gly Lys Thr Arg Leu Ala 
    930                 935                 940                 


Arg Asn Leu Leu Gln Asp Val Leu Arg Ser Trp Tyr Ala Arg Leu Pro 
945                 950                 955                 960 


Ala Val Val Gln Asn Ala His Ser Leu Val Arg Gln Thr Glu Glu Cys 
                965                 970                 975     


Ala Glu Gly Phe Arg Gln Gly Ser Leu Pro Leu Leu Gly Gln Cys Leu 
            980                 985                 990         


Thr Ser Tyr Trp Glu Gln Lys Lys  Leu Met Ala Pro Gly  Cys Glu Pro 
        995                 1000                 1005             


Leu Thr  Val Arg Arg Met Met  Asp Val Leu Ala Pro  His Val His 
    1010                 1015                 1020             


Gly Gln  Ser Leu Ala Gly Ala  Gly Gly Gly Gly Phe  Leu Tyr Leu 
    1025                 1030                 1035             


Leu Thr  Lys Glu Pro Gln Gln  Lys Glu Ala Leu Glu  Ala Val Leu 
    1040                 1045                 1050             


Ala Lys  Thr Glu Gly Leu Gly  Asn Tyr Ser Ile His  Leu Val Glu 
    1055                 1060                 1065             


Val Asp  Thr Gln Gly Leu Ser  Leu Lys Leu Leu Gly  Thr Glu Ala 
    1070                 1075                 1080             


Ser Thr  Cys Cys Pro Phe Pro  
    1085                 1090 


<210> 6572
<211> 105
<212> PRT
<213> Homo sapiens

<400> 6572
Met Leu Glu Leu Ala Gln Asp Arg Leu Gln Phe Glu Thr Val Glu Val 
1               5                   10                  15      


Ser Glu Pro Ser Met Leu Gln Lys Ile Leu Thr Thr Arg Arg Arg Glu 
            20                  25                  30          


Thr Gly Gly Asn Glu Pro Leu Pro Val Pro Thr Leu Gln His His Leu 
        35                  40                  45              


Ala Pro Pro Ala Glu Ala Arg Lys Val Pro Ser Ala Ser Gln Val Gln 
    50                  55                  60                  


Ala Ile Lys Cys Phe Leu Ser Lys Cys Trp Ser Leu Asn Ile Ser Thr 
65                  70                  75                  80  


Lys Glu Tyr Ala Tyr Leu Lys Gly Thr Val Leu Phe Asn Pro Gly Lys 
                85                  90                  95      


Gly Lys Glu Asn Asp Cys Asn His His 
            100                 105 


<210> 6573
<211> 470
<212> PRT
<213> Homo sapiens

<400> 6573
Met Ala Gly Glu Asn His Gln Trp Gln Gly Ser Ile Leu Tyr Asn Met 
1               5                   10                  15      


Leu Met Ser Ala Lys Gln Thr Arg Ala Ala Pro Glu Ala Pro Glu Thr 
            20                  25                  30          


Arg Leu Val Asp Gln Cys Trp Gly Cys Ser Cys Gly Asp Glu Pro Gly 
        35                  40                  45              


Val Gly Arg Glu Gly Leu Leu Gly Gly Arg Asn Val Ala Leu Leu Tyr 
    50                  55                  60                  


Arg Cys Cys Phe Cys Gly Lys Asp His Pro Arg Gln Gly Ser Ile Leu 
65                  70                  75                  80  


Tyr Ser Met Leu Thr Ser Ala Lys Gln Thr Tyr Ala Ala Pro Lys Ala 
                85                  90                  95      


Pro Glu Ala Thr Leu Gly Pro Cys Trp Gly Cys Ser Cys Gly Ser Asp 
            100                 105                 110         


Pro Gly Val Gly Arg Ala Gly Leu Pro Gly Gly Arg Pro Val Ala Leu 
        115                 120                 125             


Leu Tyr Arg Cys Cys Phe Cys Gly Glu Asp His Pro Arg Gln Gly Ser 
    130                 135                 140                 


Ile Leu Tyr Ser Leu Leu Thr Ser Ser Lys Gln Thr His Val Ala Pro 
145                 150                 155                 160 


Ala Ala Pro Glu Ala Arg Pro Gly Gly Ala Trp Trp Asp Arg Ser Tyr 
                165                 170                 175     


Phe Ala Gln Arg Pro Gly Gly Lys Glu Ala Leu Pro Gly Gly Arg Ala 
            180                 185                 190         


Thr Ala Leu Leu Tyr Arg Cys Cys Phe Cys Gly Glu Asp His Pro Gln 
        195                 200                 205             


Gln Gly Ser Thr Leu Tyr Cys Val Pro Thr Ser Thr Asn Gln Ala Gln 
    210                 215                 220                 


Ala Ala Pro Glu Glu Arg Pro Arg Ala Pro Trp Trp Asp Thr Ser Ser 
225                 230                 235                 240 


Gly Ala Leu Arg Pro Val Ala Leu Lys Ser Pro Gln Val Val Cys Glu 
                245                 250                 255     


Ala Ala Ser Ala Gly Leu Leu Lys Thr Leu Arg Phe Val Lys Tyr Leu 
            260                 265                 270         


Pro Cys Phe Gln Val Leu Pro Leu Asp Gln Gln Leu Val Leu Val Arg 
        275                 280                 285             


Asn Cys Trp Ala Ser Leu Leu Met Leu Glu Leu Ala Gln Asp Arg Leu 
    290                 295                 300                 


Gln Phe Glu Thr Val Glu Val Ser Glu Pro Ser Met Leu Gln Lys Ile 
305                 310                 315                 320 


Leu Thr Thr Arg Arg Arg Glu Thr Gly Gly Asn Glu Pro Leu Pro Val 
                325                 330                 335     


Pro Thr Leu Gln His His Leu Ala Pro Pro Ala Glu Ala Arg Lys Val 
            340                 345                 350         


Pro Ser Ala Ser Gln Val Gln Ala Ile Lys Cys Phe Leu Ser Lys Cys 
        355                 360                 365             


Trp Ser Leu Asn Ile Ser Thr Lys Glu Tyr Ala Tyr Leu Lys Gly Thr 
    370                 375                 380                 


Val Leu Phe Asn Pro Asp Val Pro Gly Leu Gln Cys Val Lys Tyr Ile 
385                 390                 395                 400 


Gln Gly Leu Gln Trp Gly Thr Gln Gln Ile Leu Ser Glu His Thr Arg 
                405                 410                 415     


Met Thr His Gln Gly Pro His Asp Arg Phe Ile Glu Leu Asn Ser Thr 
            420                 425                 430         


Leu Phe Leu Leu Arg Phe Ile Asn Ala Asn Val Ile Ala Glu Leu Phe 
        435                 440                 445             


Phe Arg Pro Ile Ile Gly Thr Val Ser Met Asp Asp Met Met Leu Glu 
    450                 455                 460                 


Met Leu Cys Thr Lys Ile 
465                 470 


<210> 6574
<211> 675
<212> PRT
<213> Homo sapiens

<400> 6574
Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15      


Ala Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Ser Arg His Leu 
            20                  25                  30          


Gly Gly Glu Gln Ser Gln Ala Gly Ala Pro Glu Gly Ser Lys Met Leu 
        35                  40                  45              


Arg Ala Thr Ala Pro Cys Trp Phe Arg Pro Gly Tyr Pro Glu Ala Lys 
    50                  55                  60                  


Lys Val Ala Lys Glu Ala Ala Pro Glu Ala Ser Arg His Leu Gly Ala 
65                  70                  75                  80  


Glu Gln Ser Pro Ala Gly Ala Pro Glu Gly Ser Lys Met Leu Arg Ala 
                85                  90                  95      


Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu Ala Lys Lys Val 
            100                 105                 110         


Ala Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro Leu Pro Ser His 
        115                 120                 125             


Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln Met His Lys Gln 
    130                 135                 140                 


Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln Asn Arg Gly Pro 
145                 150                 155                 160 


Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu Ser Cys Tyr Phe 
                165                 170                 175     


Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala Ala Pro Arg Leu 
            180                 185                 190         


Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro Arg Lys Arg Lys 
        195                 200                 205             


Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr Gly Tyr Thr Asp 
    210                 215                 220                 


Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg Ser Arg Gly Ser 
225                 230                 235                 240 


Lys Val Gly Arg Gln Pro Gly Lys Thr Arg Asn Arg Ser Gly Met Ala 
                245                 250                 255     


Cys Lys Thr Thr Ala Thr Thr Ser Ser Lys Arg Ile Val Arg Arg Ala 
            260                 265                 270         


Ser Leu Pro Ser Leu Ser Leu Lys Lys Pro Ile Ile Leu Arg Ser Ser 
        275                 280                 285             


Gly Cys Gln Val Pro Thr Val Leu Arg Arg Gly Tyr Leu Gln Leu Phe 
    290                 295                 300                 


Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala Glu Glu 
305                 310                 315                 320 


Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro Asn Lys 
                325                 330                 335     


Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu Lys Gly 
            340                 345                 350         


Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu Tyr Ser 
        355                 360                 365             


Arg Leu Gln Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu Asn Gly 
    370                 375                 380                 


Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu Phe Thr 
385                 390                 395                 400 


Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys Cys Arg 
                405                 410                 415     


Cys Gly Thr Glu Tyr Leu Val Ser Ser Ser Gly Arg Cys Val Arg Asp 
            420                 425                 430         


Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln Val Ala 
        435                 440                 445             


Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro Gly Ser 
    450                 455                 460                 


Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg Lys Glu 
465                 470                 475                 480 


Ser Leu Asp Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser Arg Asp 
                485                 490                 495     


Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr Thr Thr 
            500                 505                 510         


His Gly Leu Glu Leu Thr Arg Val Thr Val Val Asp Ala Asp Met Arg 
        515                 520                 525             


Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val Asp Tyr 
    530                 535                 540                 


Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys Thr Ser 
545                 550                 555                 560 


Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe Ser Ala 
                565                 570                 575     


Gln Thr Ile Leu Ile Gly His Ser Leu Glu Ser Asp Leu Leu Ala Leu 
            580                 585                 590         


Lys Leu Ile His Ser Thr Val Val Asp Thr Ala Val Leu Phe Pro His 
        595                 600                 605             


Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala Ala Asp 
    610                 615                 620                 


Tyr Leu Ala Gln Ile Ile Gln Asp Ser Gln Asp Gly His Asn Ser Ser 
625                 630                 635                 640 


Glu Asp Ala Ser Ala Cys Leu Gln Leu Val Met Trp Lys Val Arg Gln 
                645                 650                 655     


Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Ser Pro Ala Ala Leu 
            660                 665                 670         


Ala Cys Pro 
        675 


<210> 6575
<211> 236
<212> PRT
<213> Homo sapiens

<400> 6575
Met His Thr Thr Gln Lys Asp Thr Thr Tyr Thr Lys Ile Phe Val Gly 
1               5                   10                  15      


Gly Leu Pro Tyr His Thr Thr Asp Ala Ser Leu Arg Lys Tyr Phe Glu 
            20                  25                  30          


Val Phe Gly Glu Ile Glu Glu Ala Val Val Ile Thr Asp Arg Gln Thr 
        35                  40                  45              


Gly Lys Ser Arg Gly Tyr Gly Phe Val Thr Met Ala Asp Arg Ala Ala 
    50                  55                  60                  


Ala Glu Arg Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp Gly Arg Lys 
65                  70                  75                  80  


Ala Asn Val Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg Ile Met Gln 
                85                  90                  95      


Pro Gly Phe Ala Phe Gly Val Gln Gln Leu His Pro Ala Leu Ile Gln 
            100                 105                 110         


Arg Pro Phe Gly Ile Pro Ala His Tyr Val Tyr Pro Gln Ala Phe Val 
        115                 120                 125             


Gln Pro Gly Val Val Ile Pro His Val Gln Pro Thr Ala Ala Ala Ala 
    130                 135                 140                 


Ser Thr Thr Pro Tyr Ile Asp Tyr Thr Gly Ala Ala Tyr Ala Gln Tyr 
145                 150                 155                 160 


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Asp Gln Tyr 
                165                 170                 175     


Pro Tyr Ala Ala Ser Pro Ala Ala Ala Gly Tyr Val Thr Ala Gly Gly 
            180                 185                 190         


Tyr Gly Tyr Ala Val Gln Gln Pro Ile Thr Ala Ala Ala Pro Gly Thr 
        195                 200                 205             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe Gly Gln 
    210                 215                 220                 


Tyr Gln Pro Gln Gln Leu Gln Thr Asp Arg Met Gln 
225                 230                 235     


<210> 6576
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 6576
Met Ala Pro Val His Gly Asp Asp Ser Leu Ser Asp Ser Gly Ser Phe 
1               5                   10                  15      


Val Ser Ser Arg Ala Arg Arg Glu Lys Lys Ser Lys Lys Gly Arg Gln 
            20                  25                  30          


Glu Ala Leu Glu Arg Leu Lys Lys Ala Lys Ala Gly Glu Lys Tyr Lys 
        35                  40                  45              


Tyr Glu Val Glu Asp Phe Thr Gly Val Tyr Glu Glu Val Asp Glu Glu 
    50                  55                  60                  


Gln Tyr Ser Lys Leu Val Gln Ala Arg Gln Asp Asp Asp Trp Ile Val 
65                  70                  75                  80  


Asp Asp Asp Gly Ile Gly Tyr Val Glu Asp Gly Arg Glu Ile Phe Asp 
                85                  90                  95      


Asp Asp Leu Glu Asp Asp Ala Leu Asp Ala Asp Glu Lys Gly Lys Asp 
            100                 105                 110         


Gly Lys Ala Arg Asn Lys Asp Lys Arg Asn Val Lys Lys Leu Ala Val 
        115                 120                 125             


Thr Lys Pro Asn Asn Ile Lys Ser Met Phe Ile Ala Cys Ala Gly Lys 
    130                 135                 140                 


Lys Thr Ala Asp Lys Ala Val Asp Leu Ser Lys Asp Gly Leu Leu Gly 
145                 150                 155                 160 


Asp Ile Leu Gln Asp Leu Asn Thr Glu Thr Pro Gln Ile Thr Pro Pro 
                165                 170                 175     


Pro Val Met Ile Leu Lys Lys Lys Arg Ser Ile Gly Ala Ser Pro Asn 
            180                 185                 190         


Pro Phe Ser Val His Thr Ala Thr Ala Val Pro Ser Gly Lys Ile Ala 
        195                 200                 205             


Ser Pro Val Ser Arg Lys Glu Pro Pro Leu Thr Pro Val Pro Leu Lys 
    210                 215                 220                 


Arg Ala Glu Phe Ala Gly Asp Asp Val Gln Val Glu Ser Thr Glu Glu 
225                 230                 235                 240 


Glu Gln Glu Ser Gly Ala Met Glu Phe Glu Asp Gly Asp Phe Asp Glu 
                245                 250                 255     


Pro Met Glu Val Glu Glu Val Asp Leu Glu Pro Met Ala Ala Lys Ala 
            260                 265                 270         


Trp Asp Lys Glu Ser Glu Pro Ala Glu Glu Val Lys Gln Glu Ala Asp 
        275                 280                 285             


Ser Gly Lys Gly Thr Val Ser Tyr Leu Gly Ser Phe Leu Pro Asp Val 
    290                 295                 300                 


Ser Cys Trp Asp Ile Asp Gln Glu Gly Asp Ser Ser Phe Ser Val Gln 
305                 310                 315                 320 


Glu Val Gln Val Asp Ser Ser His Leu Pro Leu Val Lys Gly Ala Asp 
                325                 330                 335     


Glu Glu Gln Val Phe His Phe Tyr Trp Leu Asp Ala Tyr Glu Asp Gln 
            340                 345                 350         


Tyr Asn Gln Pro Gly Val Val Phe Leu Phe Gly Lys Val Trp Ile Glu 
        355                 360                 365             


Ser Ala Glu Thr His Val Ser Cys Cys Val Met Val Lys Asn Ile Glu 
    370                 375                 380                 


Arg Thr Leu Tyr Phe Leu Pro Arg Glu Met Lys Ile Asp Leu Asn Thr 
385                 390                 395                 400 


Gly Lys Glu Thr Gly Thr Pro Ile Ser Met Lys Asp Val Tyr Glu Glu 
                405                 410                 415     


Phe Asp Glu Lys Ile Ala Thr Lys Tyr Lys Ile Met Lys Phe Lys Ser 
            420                 425                 430         


Lys Pro Val Glu Lys Asn Tyr Ala Phe Glu Ile Pro Asp Val Pro Glu 
        435                 440                 445             


Lys Ser Glu Tyr Leu Glu Val Lys Tyr Ser Ala Glu Met Pro Gln Leu 
    450                 455                 460                 


Pro Gln Asp Leu Lys Gly Glu Thr Phe Ser His Val Phe Gly Thr Asn 
465                 470                 475                 480 


Thr Ser Ser Leu Glu Leu Phe Leu Met Asn Arg Lys Ile Lys Gly Pro 
                485                 490                 495     


Cys Trp Leu Glu Val Lys Ser Pro Gln Leu Leu Asn Gln Pro Val Ser 
            500                 505                 510         


Trp Cys Lys Val Glu Ala Met Ala Leu Lys Pro Asp Leu Val Asn Val 
        515                 520                 525             


Ile Lys Asp Val Ser Pro Pro Pro Leu Val Val Met Ala Phe Ser Met 
    530                 535                 540                 


Lys Thr Met Gln Asn Ala Lys Asn His Gln Asn Glu Ile Ile Ala Met 
545                 550                 555                 560 


Ala Ala Leu Val His His Ser Phe Ala Leu Asp Lys Ala Ala Pro Lys 
                565                 570                 575     


Pro Pro Phe Gln Ser His Phe Cys Val Val Ser Lys Pro Lys Asp Cys 
            580                 585                 590         


Ile Phe Pro Tyr Ala Phe Lys Glu Val Ile Glu Lys Lys Asn Val Lys 
        595                 600                 605             


Val Glu Val Ala Ala Thr Glu Arg Thr Leu Leu Gly Phe Phe Leu Ala 
    610                 615                 620                 


Lys Val His Lys Ile Asp Pro Asp Ile Ile Val Gly His Asn Ile Tyr 
625                 630                 635                 640 


Gly Phe Glu Leu Glu Val Leu Leu Gln Arg Ile Asn Val Cys Lys Ala 
                645                 650                 655     


Pro His Trp Ser Lys Ile Gly Arg Leu Lys Arg Ser Asn Met Pro Lys 
            660                 665                 670         


Leu Gly Gly Arg Ser Gly Phe Gly Glu Arg Asn Ala Thr Cys Gly Arg 
        675                 680                 685             


Met Ile Cys Asp Val Glu Ile Ser Ala Lys Glu Leu Ile Arg Cys Lys 
    690                 695                 700                 


Ser Tyr His Leu Ser Glu Leu Val Gln Gln Ile Leu Lys Thr Glu Arg 
705                 710                 715                 720 


Val Val Ile Pro Met Glu Asn Ile Gln Asn Met Tyr Ser Glu Ser Ser 
                725                 730                 735     


Gln Leu Leu Tyr Leu Leu Glu His Thr Trp Lys Asp Ala Lys Phe Ile 
            740                 745                 750         


Leu Gln Ile Met Cys Glu Leu Asn Val Leu Pro Leu Ala Leu Gln Ile 
        755                 760                 765             


Thr Asn Ile Ala Gly Asn Ile Met Ser Arg Thr Leu Met Gly Gly Arg 
    770                 775                 780                 


Ser Glu Arg Asn Glu Phe Leu Leu Leu His Ala Phe Tyr Glu Asn Asn 
785                 790                 795                 800 


Tyr Ile Val Pro Asp Lys Gln Ile Phe Arg Lys Pro Gln Gln Lys Leu 
                805                 810                 815     


Gly Asp Glu Asp Glu Glu Ile Asp Gly Asp Thr Asn Lys Tyr Lys Lys 
            820                 825                 830         


Gly Arg Lys Lys Ala Ala Tyr Ala Gly Gly Leu Val Leu Asp Pro Lys 
        835                 840                 845             


Val Gly Phe Tyr Asp Lys Phe Ile Leu Leu Leu Asp Phe Asn Ser Leu 
    850                 855                 860                 


Tyr Pro Ser Ile Ile Gln Glu Phe Asn Ile Cys Phe Thr Thr Val Gln 
865                 870                 875                 880 


Arg Val Ala Ser Glu Ala Gln Lys Val Thr Glu Asp Gly Glu Gln Glu 
                885                 890                 895     


Gln Ile Pro Glu Leu Pro Asp Pro Ser Leu Glu Met Gly Ile Leu Pro 
            900                 905                 910         


Arg Glu Ile Arg Lys Leu Val Glu Arg Arg Lys Gln Val Lys Gln Leu 
        915                 920                 925             


Met Lys Gln Gln Asp Leu Asn Pro Asp Leu Ile Leu Gln Tyr Asp Ile 
    930                 935                 940                 


Arg Gln Lys Ala Leu Lys Leu Thr Ala Asn Ser Met Tyr Gly Cys Leu 
945                 950                 955                 960 


Gly Phe Ser Tyr Ser Arg Phe Tyr Ala Lys Pro Leu Ala Ala Leu Val 
                965                 970                 975     


Thr Tyr Lys Gly Arg Glu Ile Leu Met His Thr Lys Glu Met Val Gln 
            980                 985                 990         


Lys Met Asn Leu Glu Val Ile Tyr  Gly Asp Thr Asp Ser  Ile Met Ile 
        995                 1000                 1005             


Asn Thr  Asn Ser Thr Asn Leu  Glu Glu Val Phe Lys  Leu Gly Asn 
    1010                 1015                 1020             


Lys Val  Lys Ser Glu Val Asn  Lys Leu Tyr Lys Leu  Leu Glu Ile 
    1025                 1030                 1035             


Asp Ile  Asp Gly Val Phe Lys  Ser Leu Leu Leu Leu  Lys Lys Lys 
    1040                 1045                 1050             


Lys Tyr  Ala Ala Leu Val Val  Glu Pro Thr Ser Asp  Gly Asn Tyr 
    1055                 1060                 1065             


Val Thr  Lys Gln Glu Leu Lys  Gly Leu Asp Ile Val  Arg Arg Asp 
    1070                 1075                 1080             


Trp Cys  Asp Leu Ala Lys Asp  Thr Gly Asn Phe Val  Ile Gly Gln 
    1085                 1090                 1095             


Ile Leu  Ser Asp Gln Ser Arg  Asp Thr Ile Val Glu  Asn Ile Gln 
    1100                 1105                 1110             


Lys Arg  Leu Ile Glu Ile Gly  Glu Asn Val Leu Asn  Gly Ser Val 
    1115                 1120                 1125             


Pro Val  Ser Gln Phe Glu Ile  Asn Lys Ala Leu Thr  Lys Asp Pro 
    1130                 1135                 1140             


Gln Asp  Tyr Pro Asp Lys Lys  Ser Leu Pro His Val  His Val Ala 
    1145                 1150                 1155             


Leu Trp  Ile Asn Ser Gln Gly  Gly Arg Lys Val Lys  Ala Gly Asp 
    1160                 1165                 1170             


Thr Val  Ser Tyr Val Ile Cys  Gln Asp Gly Ser Asn  Leu Thr Ala 
    1175                 1180                 1185             


Ser Gln  Arg Ala Tyr Ala Pro  Glu Gln Leu Gln Lys  Gln Asp Asn 
    1190                 1195                 1200             


Leu Thr  Ile Asp Thr Gln Tyr  Tyr Leu Ala Gln Gln  Ile His Pro 
    1205                 1210                 1215             


Val Val  Ala Arg Ile Cys Glu  Pro Ile Asp Gly Ile  Asp Ala Val 
    1220                 1225                 1230             


Leu Ile  Ala Thr Trp Leu Gly  Leu Asp Pro Thr Gln  Phe Arg Val 
    1235                 1240                 1245             


His His  Tyr His Lys Asp Glu  Glu Asn Asp Ala Leu  Leu Gly Gly 
    1250                 1255                 1260             


Pro Ala  Gln Leu Thr Asp Glu  Glu Lys Tyr Arg Asp  Cys Glu Arg 
    1265                 1270                 1275             


Phe Lys  Cys Pro Cys Pro Thr  Cys Gly Thr Glu Asn  Ile Tyr Asp 
    1280                 1285                 1290             


Asn Val  Phe Asp Gly Ser Gly  Thr Asp Met Glu Pro  Ser Leu Tyr 
    1295                 1300                 1305             


Arg Cys  Ser Asn Ile Asp Cys  Lys Ala Ser Pro Leu  Thr Phe Thr 
    1310                 1315                 1320             


Val Gln  Leu Ser Asn Lys Leu  Ile Met Asp Ile Arg  Arg Phe Ile 
    1325                 1330                 1335             


Lys Lys  Tyr Tyr Asp Gly Trp  Leu Ile Cys Glu Glu  Pro Thr Cys 
    1340                 1345                 1350             


Arg Asn  Arg Thr Arg His Leu  Pro Leu Gln Phe Ser  Arg Thr Gly 
    1355                 1360                 1365             


Pro Leu  Cys Pro Ala Cys Met  Lys Ala Thr Leu Gln  Pro Glu Tyr 
    1370                 1375                 1380             


Ser Asp  Lys Ser Leu Tyr Thr  Gln Leu Cys Phe Tyr  Arg Tyr Ile 
    1385                 1390                 1395             


Phe Asp  Ala Glu Cys Ala Leu  Glu Lys Leu Thr Thr  Asp His Glu 
    1400                 1405                 1410             


Lys Asp  Lys Leu Lys Lys Gln  Phe Phe Thr Pro Lys  Val Leu Gln 
    1415                 1420                 1425             


Asp Tyr  Arg Lys Leu Lys Asn  Thr Ala Glu Gln Phe  Leu Ser Arg 
    1430                 1435                 1440             


Ser Gly  Tyr Ser Glu Val Asn  Leu Ser Lys Leu Phe  Ala Gly Cys 
    1445                 1450                 1455             


Ala Val  Lys Ser 
    1460         


<210> 6577
<211> 890
<212> PRT
<213> Homo sapiens

<400> 6577
Met Ser Ala Asn Asn Ser Pro Pro Ser Ala Gln Lys Ser Val Leu Pro 
1               5                   10                  15      


Thr Ala Ile Pro Ala Val Leu Pro Ala Ala Ser Pro Cys Ser Ser Pro 
            20                  25                  30          


Lys Thr Gly Leu Ser Ala Arg Leu Ser Asn Gly Ser Phe Ser Ala Pro 
        35                  40                  45              


Ser Leu Thr Asn Ser Arg Gly Ser Val His Thr Val Ser Phe Leu Leu 
    50                  55                  60                  


Gln Ile Gly Leu Thr Arg Glu Ser Val Thr Ile Glu Ala Gln Glu Leu 
65                  70                  75                  80  


Ser Leu Ser Ala Val Lys Asp Leu Val Cys Ser Ile Val Tyr Gln Lys 
                85                  90                  95      


Phe Pro Glu Cys Gly Phe Phe Gly Met Tyr Asp Lys Ile Leu Leu Phe 
            100                 105                 110         


Arg His Asp Met Asn Ser Glu Asn Ile Leu Gln Leu Ile Thr Ser Ala 
        115                 120                 125             


Asp Glu Ile His Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Leu 
    130                 135                 140                 


Ala Thr Val Glu Asp Phe Gln Ile Arg Pro His Thr Leu Tyr Val His 
145                 150                 155                 160 


Ser Tyr Lys Ala Pro Thr Phe Cys Asp Tyr Cys Gly Glu Met Leu Trp 
                165                 170                 175     


Gly Leu Val Arg Gln Gly Leu Lys Cys Glu Gly Cys Gly Leu Asn Tyr 
            180                 185                 190         


His Lys Arg Cys Ala Phe Lys Ile Pro Asn Asn Cys Ser Gly Val Arg 
        195                 200                 205             


Lys Arg Arg Leu Ser Asn Val Ser Leu Pro Gly Pro Gly Leu Ser Val 
    210                 215                 220                 


Pro Arg Pro Leu Gln Pro Glu Tyr Val Ala Leu Pro Ser Glu Glu Ser 
225                 230                 235                 240 


His Val His Gln Glu Pro Ser Lys Arg Ile Pro Ser Trp Ser Gly Arg 
                245                 250                 255     


Pro Ile Trp Met Glu Lys Met Val Met Cys Arg Val Lys Val Pro His 
            260                 265                 270         


Thr Phe Ala Val His Ser Tyr Thr Arg Pro Thr Ile Cys Gln Tyr Cys 
        275                 280                 285             


Lys Arg Leu Leu Lys Gly Leu Phe Arg Gln Gly Met Gln Cys Lys Asp 
    290                 295                 300                 


Cys Lys Phe Asn Cys His Lys Arg Cys Ala Ser Lys Val Pro Arg Asp 
305                 310                 315                 320 


Cys Leu Gly Glu Val Thr Phe Asn Gly Glu Pro Ser Ser Leu Gly Thr 
                325                 330                 335     


Asp Thr Asp Ile Pro Met Asp Ile Asp Asn Asn Asp Ile Asn Ser Asp 
            340                 345                 350         


Ser Ser Arg Gly Leu Asp Asp Thr Glu Glu Pro Ser Pro Pro Glu Asp 
        355                 360                 365             


Lys Met Phe Phe Leu Asp Pro Ser Asp Leu Asp Val Glu Arg Asp Glu 
    370                 375                 380                 


Glu Ala Val Lys Thr Ile Ser Pro Ser Thr Ser Asn Asn Ile Pro Leu 
385                 390                 395                 400 


Met Arg Val Val Gln Ser Ile Lys His Thr Lys Arg Lys Ser Ser Thr 
                405                 410                 415     


Met Val Lys Glu Gly Trp Met Val His Tyr Thr Ser Arg Asp Asn Leu 
            420                 425                 430         


Arg Lys Arg His Tyr Trp Arg Leu Asp Ser Lys Cys Leu Thr Leu Phe 
        435                 440                 445             


Gln Asn Glu Ser Gly Ser Lys Tyr Tyr Lys Glu Ile Pro Leu Ser Glu 
    450                 455                 460                 


Ile Leu Arg Ile Ser Ser Pro Arg Asp Phe Thr Asn Ile Ser Gln Gly 
465                 470                 475                 480 


Ser Asn Pro His Cys Phe Glu Ile Ile Thr Asp Thr Met Val Tyr Phe 
                485                 490                 495     


Val Gly Glu Asn Asn Gly Asp Ser Ser His Asn Pro Val Leu Ala Ala 
            500                 505                 510         


Thr Gly Val Gly Leu Asp Val Ala Gln Ser Trp Glu Lys Ala Ile Arg 
        515                 520                 525             


Gln Ala Leu Met Pro Val Thr Pro Gln Ala Ser Val Cys Thr Ser Pro 
    530                 535                 540                 


Gly Gln Gly Lys Asp His Lys Asp Leu Ser Thr Ser Ile Ser Val Ser 
545                 550                 555                 560 


Asn Cys Gln Ile Gln Glu Asn Val Asp Ile Ser Thr Val Tyr Gln Ile 
                565                 570                 575     


Phe Ala Asp Glu Val Leu Gly Ser Gly Gln Phe Gly Ile Val Tyr Gly 
            580                 585                 590         


Gly Lys His Arg Lys Thr Gly Arg Asp Val Ala Ile Lys Val Ile Asp 
        595                 600                 605             


Lys Met Arg Phe Pro Thr Lys Gln Glu Ser Gln Leu Arg Asn Glu Val 
    610                 615                 620                 


Ala Ile Leu Gln Asn Leu His His Pro Gly Ile Val Asn Leu Glu Cys 
625                 630                 635                 640 


Met Phe Glu Thr Pro Glu Arg Val Phe Val Val Met Glu Lys Leu His 
                645                 650                 655     


Gly Asp Met Leu Glu Met Ile Leu Ser Ser Glu Lys Ser Arg Leu Pro 
            660                 665                 670         


Glu Arg Ile Thr Lys Phe Met Val Thr Gln Ile Leu Val Ala Leu Arg 
        675                 680                 685             


Asn Leu His Phe Lys Asn Ile Val His Cys Asp Leu Lys Pro Glu Asn 
    690                 695                 700                 


Val Leu Leu Ala Ser Ala Glu Pro Phe Pro Gln Val Lys Leu Cys Asp 
705                 710                 715                 720 


Phe Gly Phe Ala Arg Ile Ile Gly Glu Lys Ser Phe Arg Arg Ser Val 
                725                 730                 735     


Val Gly Thr Pro Ala Tyr Leu Ala Pro Glu Val Leu Arg Ser Lys Gly 
            740                 745                 750         


Tyr Asn Arg Ser Leu Asp Met Trp Ser Val Gly Val Ile Ile Tyr Val 
        755                 760                 765             


Ser Leu Ser Gly Thr Phe Pro Phe Asn Glu Asp Glu Asp Ile Asn Asp 
    770                 775                 780                 


Gln Ile Gln Asn Ala Ala Phe Met Tyr Pro Pro Asn Pro Trp Arg Glu 
785                 790                 795                 800 


Ile Ser Gly Glu Ala Ile Asp Leu Ile Asn Asn Leu Leu Gln Val Lys 
                805                 810                 815     


Met Arg Lys Arg Tyr Ser Val Asp Lys Ser Leu Ser His Pro Trp Leu 
            820                 825                 830         


Gln Asp Tyr Gln Thr Trp Leu Asp Leu Arg Glu Phe Glu Thr Arg Ile 
        835                 840                 845             


Gly Glu Arg Tyr Ile Thr His Glu Ser Asp Asp Ala Arg Trp Glu Ile 
    850                 855                 860                 


His Ala Tyr Thr His Asn Leu Val Tyr Pro Lys His Phe Ile Met Ala 
865                 870                 875                 880 


Pro Asn Pro Asp Asp Met Glu Glu Asp Pro 
                885                 890 


<210> 6578
<211> 1468
<212> PRT
<213> Homo sapiens

<400> 6578
Met Ala Pro Val His Gly Asp Asp Cys Glu Ile Gly Ala Ser Ala Leu 
1               5                   10                  15      


Ser Asp Ser Gly Ser Phe Val Ser Ser Arg Ala Arg Arg Glu Lys Lys 
            20                  25                  30          


Ser Lys Lys Gly Arg Gln Glu Ala Leu Glu Arg Leu Lys Lys Ala Lys 
        35                  40                  45              


Ala Gly Glu Lys Tyr Lys Tyr Glu Val Glu Asp Phe Thr Gly Val Tyr 
    50                  55                  60                  


Glu Glu Val Asp Glu Glu Gln Tyr Ser Lys Leu Val Gln Ala Arg Gln 
65                  70                  75                  80  


Asp Asp Asp Trp Ile Val Asp Asp Asp Gly Ile Gly Tyr Val Glu Asp 
                85                  90                  95      


Gly Arg Glu Ile Phe Asp Asp Asp Leu Glu Asp Asp Ala Leu Asp Ala 
            100                 105                 110         


Asp Glu Lys Gly Lys Asp Gly Lys Ala Arg Asn Lys Asp Lys Arg Asn 
        115                 120                 125             


Val Lys Lys Leu Ala Val Thr Lys Pro Asn Asn Ile Lys Ser Met Phe 
    130                 135                 140                 


Ile Ala Cys Ala Gly Lys Lys Thr Ala Asp Lys Ala Val Asp Leu Ser 
145                 150                 155                 160 


Lys Asp Gly Leu Leu Gly Asp Ile Leu Gln Asp Leu Asn Thr Glu Thr 
                165                 170                 175     


Pro Gln Ile Thr Pro Pro Pro Val Met Ile Leu Lys Lys Lys Arg Ser 
            180                 185                 190         


Ile Gly Ala Ser Pro Asn Pro Phe Ser Val His Thr Ala Thr Ala Val 
        195                 200                 205             


Pro Ser Gly Lys Ile Ala Ser Pro Val Ser Arg Lys Glu Pro Pro Leu 
    210                 215                 220                 


Thr Pro Val Pro Leu Lys Arg Ala Glu Phe Ala Gly Asp Asp Val Gln 
225                 230                 235                 240 


Val Glu Ser Thr Glu Glu Glu Gln Glu Ser Gly Ala Met Glu Phe Glu 
                245                 250                 255     


Asp Gly Asp Phe Asp Glu Pro Met Glu Val Glu Glu Val Asp Leu Glu 
            260                 265                 270         


Pro Met Ala Ala Lys Ala Trp Asp Lys Glu Ser Glu Pro Ala Glu Glu 
        275                 280                 285             


Val Lys Gln Glu Ala Asp Ser Gly Lys Gly Thr Val Ser Tyr Leu Gly 
    290                 295                 300                 


Ser Phe Leu Pro Asp Val Ser Cys Trp Asp Ile Asp Gln Glu Gly Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Val Gln Glu Val Gln Val Asp Ser Ser His Leu Pro 
                325                 330                 335     


Leu Val Lys Gly Ala Asp Glu Glu Gln Val Phe His Phe Tyr Trp Leu 
            340                 345                 350         


Asp Ala Tyr Glu Asp Gln Tyr Asn Gln Pro Gly Val Val Phe Leu Phe 
        355                 360                 365             


Gly Lys Val Trp Ile Glu Ser Ala Glu Thr His Val Ser Cys Cys Val 
    370                 375                 380                 


Met Val Lys Asn Ile Glu Arg Thr Leu Tyr Phe Leu Pro Arg Glu Met 
385                 390                 395                 400 


Lys Ile Asp Leu Asn Thr Gly Lys Glu Thr Gly Thr Pro Ile Ser Met 
                405                 410                 415     


Lys Asp Val Tyr Glu Glu Phe Asp Glu Lys Ile Ala Thr Lys Tyr Lys 
            420                 425                 430         


Ile Met Lys Phe Lys Ser Lys Pro Val Glu Lys Asn Tyr Ala Phe Glu 
        435                 440                 445             


Ile Pro Asp Val Pro Glu Lys Ser Glu Tyr Leu Glu Val Lys Tyr Ser 
    450                 455                 460                 


Ala Glu Met Pro Gln Leu Pro Gln Asp Leu Lys Gly Glu Thr Phe Ser 
465                 470                 475                 480 


His Val Phe Gly Thr Asn Thr Ser Ser Leu Glu Leu Phe Leu Met Asn 
                485                 490                 495     


Arg Lys Ile Lys Gly Pro Cys Trp Leu Glu Val Lys Ser Pro Gln Leu 
            500                 505                 510         


Leu Asn Gln Pro Val Ser Trp Cys Lys Val Glu Ala Met Ala Leu Lys 
        515                 520                 525             


Pro Asp Leu Val Asn Val Ile Lys Asp Val Ser Pro Pro Pro Leu Val 
    530                 535                 540                 


Val Met Ala Phe Ser Met Lys Thr Met Gln Asn Ala Lys Asn His Gln 
545                 550                 555                 560 


Asn Glu Ile Ile Ala Met Ala Ala Leu Val His His Ser Phe Ala Leu 
                565                 570                 575     


Asp Lys Ala Ala Pro Lys Pro Pro Phe Gln Ser His Phe Cys Val Val 
            580                 585                 590         


Ser Lys Pro Lys Asp Cys Ile Phe Pro Tyr Ala Phe Lys Glu Val Ile 
        595                 600                 605             


Glu Lys Lys Asn Val Lys Val Glu Val Ala Ala Thr Glu Arg Thr Leu 
    610                 615                 620                 


Leu Gly Phe Phe Leu Ala Lys Val His Lys Ile Asp Pro Asp Ile Ile 
625                 630                 635                 640 


Val Gly His Asn Ile Tyr Gly Phe Glu Leu Glu Val Leu Leu Gln Arg 
                645                 650                 655     


Ile Asn Val Cys Lys Ala Pro His Trp Ser Lys Ile Gly Arg Leu Lys 
            660                 665                 670         


Arg Ser Asn Met Pro Lys Leu Gly Gly Arg Ser Gly Phe Gly Glu Arg 
        675                 680                 685             


Asn Ala Thr Cys Gly Arg Met Ile Cys Asp Val Glu Ile Ser Ala Lys 
    690                 695                 700                 


Glu Leu Ile Arg Cys Lys Ser Tyr His Leu Ser Glu Leu Val Gln Gln 
705                 710                 715                 720 


Ile Leu Lys Thr Glu Arg Val Val Ile Pro Met Glu Asn Ile Gln Asn 
                725                 730                 735     


Met Tyr Ser Glu Ser Ser Gln Leu Leu Tyr Leu Leu Glu His Thr Trp 
            740                 745                 750         


Lys Asp Ala Lys Phe Ile Leu Gln Ile Met Cys Glu Leu Asn Val Leu 
        755                 760                 765             


Pro Leu Ala Leu Gln Ile Thr Asn Ile Ala Gly Asn Ile Met Ser Arg 
    770                 775                 780                 


Thr Leu Met Gly Gly Arg Ser Glu Arg Asn Glu Phe Leu Leu Leu His 
785                 790                 795                 800 


Ala Phe Tyr Glu Asn Asn Tyr Ile Val Pro Asp Lys Gln Ile Phe Arg 
                805                 810                 815     


Lys Pro Gln Gln Lys Leu Gly Asp Glu Asp Glu Glu Ile Asp Gly Asp 
            820                 825                 830         


Thr Asn Lys Tyr Lys Lys Gly Arg Lys Lys Ala Ala Tyr Ala Gly Gly 
        835                 840                 845             


Leu Val Leu Asp Pro Lys Val Gly Phe Tyr Asp Lys Phe Ile Leu Leu 
    850                 855                 860                 


Leu Asp Phe Asn Ser Leu Tyr Pro Ser Ile Ile Gln Glu Phe Asn Ile 
865                 870                 875                 880 


Cys Phe Thr Thr Val Gln Arg Val Ala Ser Glu Ala Gln Lys Val Thr 
                885                 890                 895     


Glu Asp Gly Glu Gln Glu Gln Ile Pro Glu Leu Pro Asp Pro Ser Leu 
            900                 905                 910         


Glu Met Gly Ile Leu Pro Arg Glu Ile Arg Lys Leu Val Glu Arg Arg 
        915                 920                 925             


Lys Gln Val Lys Gln Leu Met Lys Gln Gln Asp Leu Asn Pro Asp Leu 
    930                 935                 940                 


Ile Leu Gln Tyr Asp Ile Arg Gln Lys Ala Leu Lys Leu Thr Ala Asn 
945                 950                 955                 960 


Ser Met Tyr Gly Cys Leu Gly Phe Ser Tyr Ser Arg Phe Tyr Ala Lys 
                965                 970                 975     


Pro Leu Ala Ala Leu Val Thr Tyr Lys Gly Arg Glu Ile Leu Met His 
            980                 985                 990         


Thr Lys Glu Met Val Gln Lys Met  Asn Leu Glu Val Ile  Tyr Gly Asp 
        995                 1000                 1005             


Thr Asp  Ser Ile Met Ile Asn  Thr Asn Ser Thr Asn  Leu Glu Glu 
    1010                 1015                 1020             


Val Phe  Lys Leu Gly Asn Lys  Val Lys Ser Glu Val  Asn Lys Leu 
    1025                 1030                 1035             


Tyr Lys  Leu Leu Glu Ile Asp  Ile Asp Gly Val Phe  Lys Ser Leu 
    1040                 1045                 1050             


Leu Leu  Leu Lys Lys Lys Lys  Tyr Ala Ala Leu Val  Val Glu Pro 
    1055                 1060                 1065             


Thr Ser  Asp Gly Asn Tyr Val  Thr Lys Gln Glu Leu  Lys Gly Leu 
    1070                 1075                 1080             


Asp Ile  Val Arg Arg Asp Trp  Cys Asp Leu Ala Lys  Asp Thr Gly 
    1085                 1090                 1095             


Asn Phe  Val Ile Gly Gln Ile  Leu Ser Asp Gln Ser  Arg Asp Thr 
    1100                 1105                 1110             


Ile Val  Glu Asn Ile Gln Lys  Arg Leu Ile Glu Ile  Gly Glu Asn 
    1115                 1120                 1125             


Val Leu  Asn Gly Ser Val Pro  Val Ser Gln Phe Glu  Ile Asn Lys 
    1130                 1135                 1140             


Ala Leu  Thr Lys Asp Pro Gln  Asp Tyr Pro Asp Lys  Lys Ser Leu 
    1145                 1150                 1155             


Pro His  Val His Val Ala Leu  Trp Ile Asn Ser Gln  Gly Gly Arg 
    1160                 1165                 1170             


Lys Val  Lys Ala Gly Asp Thr  Val Ser Tyr Val Ile  Cys Gln Asp 
    1175                 1180                 1185             


Gly Ser  Asn Leu Thr Ala Ser  Gln Arg Ala Tyr Ala  Pro Glu Gln 
    1190                 1195                 1200             


Leu Gln  Lys Gln Asp Asn Leu  Thr Ile Asp Thr Gln  Tyr Tyr Leu 
    1205                 1210                 1215             


Ala Gln  Gln Ile His Pro Val  Val Ala Arg Ile Cys  Glu Pro Ile 
    1220                 1225                 1230             


Asp Gly  Ile Asp Ala Val Leu  Ile Ala Thr Trp Leu  Gly Leu Asp 
    1235                 1240                 1245             


Pro Thr  Gln Phe Arg Val His  His Tyr His Lys Asp  Glu Glu Asn 
    1250                 1255                 1260             


Asp Ala  Leu Leu Gly Gly Pro  Ala Gln Leu Thr Asp  Glu Glu Lys 
    1265                 1270                 1275             


Tyr Arg  Asp Cys Glu Arg Phe  Lys Cys Pro Cys Pro  Thr Cys Gly 
    1280                 1285                 1290             


Thr Glu  Asn Ile Tyr Asp Asn  Val Phe Asp Gly Ser  Gly Thr Asp 
    1295                 1300                 1305             


Met Glu  Pro Ser Leu Tyr Arg  Cys Ser Asn Ile Asp  Cys Lys Ala 
    1310                 1315                 1320             


Ser Pro  Leu Thr Phe Thr Val  Gln Leu Ser Asn Lys  Leu Ile Met 
    1325                 1330                 1335             


Asp Ile  Arg Arg Phe Ile Lys  Lys Tyr Tyr Asp Gly  Trp Leu Ile 
    1340                 1345                 1350             


Cys Glu  Glu Pro Thr Cys Arg  Asn Arg Thr Arg His  Leu Pro Leu 
    1355                 1360                 1365             


Gln Phe  Ser Arg Thr Gly Pro  Leu Cys Pro Ala Cys  Met Lys Ala 
    1370                 1375                 1380             


Thr Leu  Gln Pro Glu Tyr Ser  Asp Lys Ser Leu Tyr  Thr Gln Leu 
    1385                 1390                 1395             


Cys Phe  Tyr Arg Tyr Ile Phe  Asp Ala Glu Cys Ala  Leu Glu Lys 
    1400                 1405                 1410             


Leu Thr  Thr Asp His Glu Lys  Asp Lys Leu Lys Lys  Gln Phe Phe 
    1415                 1420                 1425             


Thr Pro  Lys Val Leu Gln Asp  Tyr Arg Lys Leu Lys  Asn Thr Ala 
    1430                 1435                 1440             


Glu Gln  Phe Leu Ser Arg Ser  Gly Tyr Ser Glu Val  Asn Leu Ser 
    1445                 1450                 1455             


Lys Leu  Phe Ala Gly Cys Ala  Val Lys Ser 
    1460                 1465             


<210> 6579
<211> 132
<212> PRT
<213> Homo sapiens

<400> 6579
Met Val Glu Pro Phe Leu Gly Thr Trp Lys Leu Val Ser Ser Glu Asn 
1               5                   10                  15      


Phe Glu Asp Tyr Met Lys Glu Leu Gly Val Asn Phe Ala Ala Arg Asn 
            20                  25                  30          


Met Ala Gly Leu Val Lys Pro Thr Val Thr Ile Ser Val Asp Gly Lys 
        35                  40                  45              


Met Met Thr Ile Arg Thr Glu Ser Ser Phe Gln Asp Thr Lys Ile Ser 
    50                  55                  60                  


Phe Lys Leu Gly Glu Glu Phe Asp Glu Thr Thr Ala Asp Asn Arg Lys 
65                  70                  75                  80  


Val Lys Ser Thr Ile Thr Leu Glu Asn Gly Ser Met Ile His Val Gln 
                85                  90                  95      


Lys Trp Leu Gly Lys Glu Thr Thr Ile Lys Arg Lys Ile Val Asp Glu 
            100                 105                 110         


Lys Met Val Val Glu Cys Lys Met Asn Asn Ile Val Ser Thr Arg Ile 
        115                 120                 125             


Tyr Glu Lys Val 
    130         


<210> 6580
<211> 184
<212> PRT
<213> Homo sapiens

<400> 6580
Met Asp Arg Gly Glu Gln Gly Leu Leu Arg Thr Asp Pro Val Pro Glu 
1               5                   10                  15      


Glu Gly Glu Asp Val Ala Ala Thr Ile Ser Ala Thr Glu Thr Leu Ser 
            20                  25                  30          


Glu Glu Glu Gln Glu Glu Leu Arg Arg Glu Leu Ala Lys Val Glu Glu 
        35                  40                  45              


Glu Ile Gln Thr Leu Ser Gln Val Leu Ala Ala Lys Glu Lys His Leu 
    50                  55                  60                  


Ala Glu Ile Lys Arg Lys Leu Gly Ile Asn Ser Leu Gln Glu Leu Lys 
65                  70                  75                  80  


Gln Asn Ile Ala Lys Gly Trp Gln Asp Val Thr Ala Thr Ser Ala Tyr 
                85                  90                  95      


Lys Lys Thr Ser Glu Thr Leu Ser Gln Ala Gly Gln Lys Ala Ser Ala 
            100                 105                 110         


Ala Phe Ser Ser Val Gly Ser Val Ile Thr Lys Lys Leu Glu Asp Val 
        115                 120                 125             


Lys Asn Ser Pro Thr Phe Lys Ser Phe Glu Glu Lys Val Glu Asn Leu 
    130                 135                 140                 


Lys Ser Lys Val Gly Gly Thr Lys Pro Ala Gly Gly Asp Phe Gly Glu 
145                 150                 155                 160 


Val Leu Asn Ser Ala Ala Asn Ala Ser Ala Thr Thr Thr Glu Pro Leu 
                165                 170                 175     


Pro Glu Lys Thr Gln Glu Ser Leu 
            180                 


<210> 6581
<211> 224
<212> PRT
<213> Homo sapiens

<400> 6581
Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe 
1               5                   10                  15      


Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser 
            20                  25                  30          


Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu 
        35                  40                  45              


Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr 
    50                  55                  60                  


Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg 
65                  70                  75                  80  


Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly 
            100                 105                 110         


Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln 
        115                 120                 125             


Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu Thr Leu Ser 
    130                 135                 140                 


Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val Gly Ser Val 
145                 150                 155                 160 


Ile Thr Lys Lys Leu Glu Asp Val Lys Asn Ser Pro Thr Phe Lys Ser 
                165                 170                 175     


Phe Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys 
            180                 185                 190         


Pro Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala 
        195                 200                 205             


Ser Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu 
    210                 215                 220                 


<210> 6582
<211> 94
<212> PRT
<213> Homo sapiens

<400> 6582
Pro Arg Ala Ala Arg Ser Arg Gly Pro Ala Val Ser Arg Pro Arg Ala 
1               5                   10                  15      


Pro Arg Pro Glu Leu Thr Thr Glu Ala Gly Glu Pro Ala Arg Arg Cys 
            20                  25                  30          


Val Pro Pro Tyr Glu His Arg Pro Gly Met Gln Cys Ala Val Thr Thr 
        35                  40                  45              


Pro Pro Pro Ser Tyr Tyr Pro Tyr Pro Asn Leu Arg Trp Asp Thr Ser 
    50                  55                  60                  


His Phe Lys Lys Ser Gly Gly Pro Gln Arg Asn Asn Tyr Val Ile His 
65                  70                  75                  80  


Pro Glu Phe Val Ser Glu Thr Tyr Pro Asp Tyr Arg Cys Trp 
                85                  90                  


<210> 6583
<211> 369
<212> PRT
<213> Homo sapiens

<400> 6583
Met Pro Val Val Thr Thr Asp Ala Glu Ser Glu Thr Gly Ile Pro Lys 
1               5                   10                  15      


Ser Leu Ser Asn Glu Pro Pro Ser Glu Thr Met Glu Glu Ile Glu His 
            20                  25                  30          


Thr Cys Pro Gln Pro Arg Leu Thr Leu Thr Ala Pro Ala Pro Phe Ala 
        35                  40                  45              


Asp Glu Thr Asn Cys Gln Cys Gln Ala Pro His Glu Lys Leu Thr Ile 
    50                  55                  60                  


Ala Gln Ala Arg Leu Gly Thr Pro Ala Asp Arg Pro Val Arg Val Tyr 
65                  70                  75                  80  


Ala Asp Gly Ile Phe Asp Leu Phe His Ser Gly His Ala Arg Ala Leu 
                85                  90                  95      


Met Gln Ala Lys Thr Leu Phe Pro Asn Ser Tyr Leu Leu Val Gly Val 
            100                 105                 110         


Cys Ser Asp Asp Leu Thr His Lys Phe Lys Gly Phe Thr Val Met Asn 
        115                 120                 125             


Glu Ala Glu Arg Tyr Glu Ala Leu Arg His Cys Arg Tyr Val Asp Glu 
    130                 135                 140                 


Val Ile Arg Asp Ala Pro Trp Thr Leu Thr Pro Glu Phe Leu Glu Lys 
145                 150                 155                 160 


His Lys Ile Asp Phe Val Ala His Asp Asp Ile Pro Tyr Ser Ser Ala 
                165                 170                 175     


Gly Ser Asp Asp Val Tyr Lys His Ile Lys Glu Ala Gly Met Phe Val 
            180                 185                 190         


Pro Thr Gln Arg Thr Glu Gly Ile Ser Thr Ser Asp Ile Ile Thr Arg 
        195                 200                 205             


Ile Val Arg Asp Tyr Asp Val Tyr Ala Arg Arg Asn Leu Gln Arg Gly 
    210                 215                 220                 


Tyr Thr Ala Lys Glu Leu Asn Val Ser Phe Ile Asn Glu Lys Arg Tyr 
225                 230                 235                 240 


Arg Phe Gln Asn Gln Val Asp Lys Met Lys Glu Lys Val Lys Asn Val 
                245                 250                 255     


Glu Glu Arg Ser Lys Glu Phe Val Asn Arg Val Glu Glu Lys Ser His 
            260                 265                 270         


Asp Leu Ile Gln Lys Trp Glu Glu Lys Ser Arg Glu Phe Ile Gly Asn 
        275                 280                 285             


Phe Leu Glu Leu Phe Gly Pro Asp Gly Ala Trp Lys Gln Met Phe Gln 
    290                 295                 300                 


Glu Arg Ser Ser Arg Met Leu Gln Ala Leu Ser Pro Lys Gln Ser Pro 
305                 310                 315                 320 


Val Ser Ser Pro Thr Arg Ser Arg Ser Pro Ser Arg Ser Pro Ser Pro 
                325                 330                 335     


Thr Phe Ser Trp Leu Pro Leu Lys Thr Ser Pro Pro Ser Ser Pro Lys 
            340                 345                 350         


Ala Ala Ser Ala Ser Ile Ser Ser Met Ser Glu Gly Asp Glu Asp Glu 
        355                 360                 365             


Lys 
    


<210> 6584
<211> 351
<212> PRT
<213> Homo sapiens

<400> 6584
Met Val Gly His Gln Glu Cys Ile Met Glu Glu Asp Asn Arg Ala Pro 
1               5                   10                  15      


Gln Leu Trp Arg Lys Thr Leu Thr Ala Pro Ala Pro Phe Ala Asp Glu 
            20                  25                  30          


Thr Asn Cys Gln Cys Gln Ala Pro His Glu Lys Leu Thr Ile Ala Gln 
        35                  40                  45              


Ala Arg Leu Gly Thr Pro Ala Asp Arg Pro Val Arg Val Tyr Ala Asp 
    50                  55                  60                  


Gly Ile Phe Asp Leu Phe His Ser Gly His Ala Arg Ala Leu Met Gln 
65                  70                  75                  80  


Ala Lys Thr Leu Phe Pro Asn Ser Tyr Leu Leu Val Gly Val Cys Ser 
                85                  90                  95      


Asp Asp Leu Thr His Lys Phe Lys Gly Phe Thr Val Met Asn Glu Ala 
            100                 105                 110         


Glu Arg Tyr Glu Ala Leu Arg His Cys Arg Tyr Val Asp Glu Val Ile 
        115                 120                 125             


Arg Asp Ala Pro Trp Thr Leu Thr Pro Glu Phe Leu Glu Lys His Lys 
    130                 135                 140                 


Ile Asp Phe Val Ala His Asp Asp Ile Pro Tyr Ser Ser Ala Gly Ser 
145                 150                 155                 160 


Asp Asp Val Tyr Lys His Ile Lys Glu Ala Gly Met Phe Val Pro Thr 
                165                 170                 175     


Gln Arg Thr Glu Gly Ile Ser Thr Ser Asp Ile Ile Thr Arg Ile Val 
            180                 185                 190         


Arg Asp Tyr Asp Val Tyr Ala Arg Arg Asn Leu Gln Arg Gly Tyr Thr 
        195                 200                 205             


Ala Lys Glu Leu Asn Val Ser Phe Ile Asn Glu Lys Arg Tyr Arg Phe 
    210                 215                 220                 


Gln Asn Gln Val Asp Lys Met Lys Glu Lys Val Lys Asn Val Glu Glu 
225                 230                 235                 240 


Arg Ser Lys Glu Phe Val Asn Arg Val Glu Glu Lys Ser His Asp Leu 
                245                 250                 255     


Ile Gln Lys Trp Glu Glu Lys Ser Arg Glu Phe Ile Gly Asn Phe Leu 
            260                 265                 270         


Glu Leu Phe Gly Pro Asp Gly Ala Trp Lys Gln Met Phe Gln Glu Arg 
        275                 280                 285             


Ser Ser Arg Met Leu Gln Ala Leu Ser Pro Lys Gln Ser Pro Val Ser 
    290                 295                 300                 


Ser Pro Thr Arg Ser Arg Ser Pro Ser Arg Ser Pro Ser Pro Thr Phe 
305                 310                 315                 320 


Ser Trp Leu Pro Leu Lys Thr Ser Pro Pro Ser Ser Pro Lys Ala Ala 
                325                 330                 335     


Ser Ala Ser Ile Ser Ser Met Ser Glu Gly Asp Glu Asp Glu Lys 
            340                 345                 350     


<210> 6585
<211> 199
<212> PRT
<213> Homo sapiens

<400> 6585
Met Ala Asp Lys Ser Lys Phe Ile Glu Tyr Ile Asp Glu Ala Leu Glu 
1               5                   10                  15      


Lys Ser Lys Glu Thr Ala Leu Ser His Leu Phe Phe Thr Tyr Gln Gly 
            20                  25                  30          


Ile Pro Tyr Pro Ile Thr Met Cys Thr Ser Glu Thr Phe Gln Ala Leu 
        35                  40                  45              


Asp Thr Phe Glu Ala Arg His Asp Asp Ile Val Leu Ala Ser Tyr Pro 
    50                  55                  60                  


Lys Cys Gly Ser Asn Trp Ile Leu His Ile Val Ser Glu Leu Ile Tyr 
65                  70                  75                  80  


Ala Val Ser Lys Lys Lys Tyr Lys Tyr Pro Glu Phe Pro Val Leu Glu 
                85                  90                  95      


Cys Gly Asp Ser Glu Lys Tyr Gln Asn Leu Ala Ala Gly Ile Lys Gln 
            100                 105                 110         


Ile Ala Glu Phe Leu Gly Phe Phe Leu Thr Gly Glu Gln Ile Gln Thr 
        115                 120                 125             


Ile Ser Val Gln Ser Thr Phe Gln Ala Met Arg Ala Lys Ser Gln Asp 
    130                 135                 140                 


Thr His Gly Ala Val Gly Pro Phe Leu Phe Arg Lys Gly Glu Val Gly 
145                 150                 155                 160 


Asp Trp Lys Asn Leu Phe Ser Glu Ile Gln Asn Gln Glu Met Asp Glu 
                165                 170                 175     


Lys Phe Lys Glu Cys Leu Ala Gly Thr Ser Leu Gly Ala Lys Leu Lys 
            180                 185                 190         


Tyr Glu Ser Tyr Cys Gln Gly 
        195                 


<210> 6586
<211> 508
<212> PRT
<213> Homo sapiens

<400> 6586
Met Arg Cys Pro Lys Ser Ala Val Thr Met Arg Asn Glu Glu Leu Leu 
1               5                   10                  15      


Leu Ser Asn Gly Thr Ala Asn Lys Met Asn Gly Ala Leu Asp His Ser 
            20                  25                  30          


Asp Gln Pro Asp Pro Asp Ala Ile Lys Met Phe Val Gly Gln Ile Pro 
        35                  40                  45              


Arg Ser Trp Ser Glu Lys Glu Leu Lys Glu Leu Phe Glu Pro Tyr Gly 
    50                  55                  60                  


Ala Val Tyr Gln Ile Asn Val Leu Arg Asp Arg Ser Gln Asn Pro Pro 
65                  70                  75                  80  


Gln Ser Lys Gly Cys Cys Phe Val Thr Phe Tyr Thr Arg Lys Ala Ala 
                85                  90                  95      


Leu Glu Ala Gln Asn Ala Leu His Asn Ile Lys Thr Leu Pro Gly Met 
            100                 105                 110         


His His Pro Ile Gln Met Lys Pro Ala Asp Ser Glu Lys Ser Asn Ala 
        115                 120                 125             


Val Glu Asp Arg Lys Leu Phe Ile Gly Met Val Ser Lys Lys Cys Asn 
    130                 135                 140                 


Glu Asn Asp Ile Arg Val Met Phe Ser Pro Phe Gly Gln Ile Glu Glu 
145                 150                 155                 160 


Cys Arg Ile Leu Arg Gly Pro Asp Gly Leu Ser Arg Gly Cys Ala Phe 
                165                 170                 175     


Val Thr Phe Ser Thr Arg Ala Met Ala Gln Asn Ala Ile Lys Ala Met 
            180                 185                 190         


His Gln Ser Gln Thr Met Glu Gly Cys Ser Ser Pro Ile Val Val Lys 
        195                 200                 205             


Phe Ala Asp Thr Gln Lys Asp Lys Glu Gln Arg Arg Leu Gln Gln Gln 
    210                 215                 220                 


Leu Ala Gln Gln Met Gln Gln Leu Asn Thr Ala Thr Trp Gly Asn Leu 
225                 230                 235                 240 


Thr Gly Leu Gly Gly Leu Thr Pro Gln Tyr Leu Ala Leu Leu Gln Gln 
                245                 250                 255     


Ala Thr Ser Ser Ser Asn Leu Gly Ala Phe Ser Gly Ile Gln Gln Met 
            260                 265                 270         


Ala Gly Met Asn Ala Leu Gln Leu Gln Asn Leu Ala Thr Leu Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Gln Thr Ser Ala Thr Ser Thr Asn Ala Asn Pro 
    290                 295                 300                 


Leu Ser Thr Thr Ser Ser Ala Leu Gly Ala Leu Thr Ser Pro Val Ala 
305                 310                 315                 320 


Ala Ser Thr Pro Asn Ser Thr Ala Gly Ala Ala Met Asn Ser Leu Thr 
                325                 330                 335     


Ser Leu Gly Thr Leu Gln Gly Leu Ala Gly Ala Thr Val Gly Leu Asn 
            340                 345                 350         


Asn Ile Asn Ala Leu Ala Gly Met Ala Ala Leu Asn Gly Gly Leu Gly 
        355                 360                 365             


Ala Thr Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr 
    370                 375                 380                 


Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr 
385                 390                 395                 400 


Leu Tyr Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln 
                405                 410                 415     


Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln 
            420                 425                 430         


Glu Phe Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn 
        435                 440                 445             


Val Ile Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys 
    450                 455                 460                 


Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala 
465                 470                 475                 480 


Ile Gln Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val 
                485                 490                 495     


Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
            500                 505             


<210> 6587
<211> 404
<212> PRT
<213> Homo sapiens

<400> 6587
Met Gly Ser Ser Gln Glu Glu Gly Leu Arg Cys Gln Pro Ser Gln Pro 
1               5                   10                  15      


Asp His Asp Ala Asp Gly His Cys Gly Pro Asp Leu Glu Gly Ala Glu 
            20                  25                  30          


Arg Ala Ser Ala Thr Pro Gly Pro Pro Gly Leu Leu Asn Ser His Arg 
        35                  40                  45              


Pro Ala Asp Ser Asp Asp Thr Asn Ala Ala Gly Pro Ser Ala Ala Leu 
    50                  55                  60                  


Leu Glu Gly Leu Leu Leu Gly Gly Gly Lys Pro Ser Pro His Ser Thr 
65                  70                  75                  80  


Arg Pro Gly Pro Phe Phe Tyr Ile Gly Gly Ser Asn Gly Ala Thr Ile 
                85                  90                  95      


Ile Ser Ser Tyr Cys Lys Ser Lys Gly Trp Gln Arg Ile His Asp Ser 
            100                 105                 110         


Arg Arg Asp Asp Tyr Thr Leu Lys Trp Cys Glu Val Lys Ser Arg Asp 
        115                 120                 125             


Ser Tyr Gly Ser Phe Arg Glu Gly Glu Gln Leu Leu Tyr Gln Leu Pro 
    130                 135                 140                 


Asn Asn Lys Leu Leu Thr Thr Lys Ile Gly Leu Leu Ser Thr Leu Arg 
145                 150                 155                 160 


Gly Arg Ala Arg Ala Met Ser Lys Ala Ser Lys Val Pro Gly Gly Val 
                165                 170                 175     


Gln Ala Arg Leu Glu Lys Asp Ala Ala Ala Pro Ala Leu Glu Asp Leu 
            180                 185                 190         


Pro Trp Thr Ser Pro Gly Tyr Leu Arg Pro Gln Arg Val Leu Arg Met 
        195                 200                 205             


Glu Glu Phe Phe Pro Glu Thr Tyr Arg Leu Asp Leu Lys His Glu Arg 
    210                 215                 220                 


Glu Ala Phe Phe Thr Leu Phe Asp Glu Thr Gln Ile Trp Ile Cys Lys 
225                 230                 235                 240 


Pro Thr Ala Ser Asn Gln Gly Lys Gly Ile Phe Leu Leu Arg Asn Gln 
                245                 250                 255     


Glu Glu Val Ala Ala Leu Gln Ala Lys Thr Arg Ser Met Glu Asp Asp 
            260                 265                 270         


Pro Ile His His Lys Thr Pro Phe Arg Gly Pro Gln Ala Arg Val Val 
        275                 280                 285             


Gln Arg Tyr Ile Gln Asn Pro Leu Leu Val Asp Gly Arg Lys Phe Asp 
    290                 295                 300                 


Val Arg Ser Tyr Leu Leu Ile Ala Cys Thr Thr Pro Tyr Met Ile Phe 
305                 310                 315                 320 


Phe Gly His Gly Tyr Ala Arg Leu Thr Leu Ser Leu Tyr Asp Pro His 
                325                 330                 335     


Ser Ser Asp Leu Gly Gly His Leu Thr Asn Gln Phe Met Gln Lys Lys 
            340                 345                 350         


Ser Pro Leu Tyr Met Leu Leu Lys Glu His Thr Val Trp Ser Met Glu 
        355                 360                 365             


His Leu Asn Arg Tyr Ile Ser Asp Thr Phe Trp Lys Ala Arg Gly Leu 
    370                 375                 380                 


Ala Lys Asp Trp Val Phe Thr Thr Leu Lys Val Arg Pro Leu Cys Pro 
385                 390                 395                 400 


Pro Val Trp Glu 
                


<210> 6588
<211> 673
<212> PRT
<213> Homo sapiens

<400> 6588
Met Asp His Ser Cys Thr Arg Phe Ile His Arg Arg Gly Pro Pro Thr 
1               5                   10                  15      


Arg Thr Arg Ala Gly Phe Lys Arg Gly Lys Arg Pro Arg Ile Gln Gln 
            20                  25                  30          


Arg Pro Arg Ala Arg Val Ser Gly Thr Ile Pro Ala Ser Arg Leu His 
        35                  40                  45              


Pro Ala Pro Ala Ser Gln Pro Gly Pro Cys Pro Ala Pro Gly His Cys 
    50                  55                  60                  


Pro Val Gly Pro Ala His Glu Arg Pro Met Gly Ser Ser Gln Glu Glu 
65                  70                  75                  80  


Gly Leu Arg Cys Gln Pro Ser Gln Pro Asp His Asp Ala Asp Gly His 
                85                  90                  95      


Cys Gly Pro Asp Leu Glu Gly Ala Glu Arg Ala Ser Ala Thr Pro Gly 
            100                 105                 110         


Pro Pro Gly Leu Leu Asn Ser His Arg Pro Ala Asp Ser Asp Asp Thr 
        115                 120                 125             


Asn Ala Ala Gly Pro Ser Ala Ala Leu Leu Glu Gly Leu Leu Leu Gly 
    130                 135                 140                 


Gly Gly Lys Pro Ser Pro His Ser Thr Arg Pro Gly Pro Phe Phe Tyr 
145                 150                 155                 160 


Ile Gly Gly Ser Asn Gly Ala Thr Ile Ile Ser Ser Tyr Cys Lys Ser 
                165                 170                 175     


Lys Gly Trp Gln Arg Ile His Asp Ser Arg Arg Asp Asp Tyr Thr Leu 
            180                 185                 190         


Lys Trp Cys Glu Val Lys Ser Arg Asp Ser Tyr Gly Ser Phe Arg Glu 
        195                 200                 205             


Gly Glu Gln Leu Leu Tyr Gln Leu Pro Asn Asn Lys Leu Leu Thr Thr 
    210                 215                 220                 


Lys Ile Gly Leu Leu Ser Thr Leu Arg Gly Arg Ala Arg Ala Met Ser 
225                 230                 235                 240 


Lys Ala Ser Lys Val Pro Gly Gly Val Gln Ala Arg Leu Glu Lys Asp 
                245                 250                 255     


Ala Ala Ala Pro Ala Leu Glu Asp Leu Pro Trp Thr Ser Pro Gly Tyr 
            260                 265                 270         


Leu Arg Pro Gln Arg Val Leu Arg Met Glu Glu Phe Phe Pro Glu Thr 
        275                 280                 285             


Tyr Arg Leu Asp Leu Lys His Glu Arg Glu Ala Phe Phe Thr Leu Phe 
    290                 295                 300                 


Asp Glu Thr Gln Ile Trp Ile Cys Lys Pro Thr Ala Ser Asn Gln Gly 
305                 310                 315                 320 


Lys Gly Ile Phe Leu Leu Arg Asn Gln Glu Glu Val Ala Ala Leu Gln 
                325                 330                 335     


Ala Lys Thr Arg Ser Met Glu Asp Asp Pro Ile His His Lys Thr Pro 
            340                 345                 350         


Phe Arg Gly Pro Gln Ala Arg Val Val Gln Arg Tyr Ile Gln Asn Pro 
        355                 360                 365             


Leu Leu Val Asp Gly Arg Lys Phe Asp Val Arg Ser Tyr Leu Leu Ile 
    370                 375                 380                 


Ala Cys Thr Thr Pro Tyr Met Ile Phe Phe Gly His Gly Tyr Ala Arg 
385                 390                 395                 400 


Leu Thr Leu Ser Leu Tyr Asp Pro His Ser Ser Asp Leu Gly Gly His 
                405                 410                 415     


Leu Thr Asn Gln Phe Met Gln Lys Lys Ser Pro Leu Tyr Met Leu Leu 
            420                 425                 430         


Lys Glu His Thr Val Trp Ser Met Glu His Leu Asn Arg Tyr Ile Ser 
        435                 440                 445             


Asp Thr Phe Trp Lys Ala Arg Gly Leu Ala Lys Asp Trp Val Phe Thr 
    450                 455                 460                 


Thr Leu Lys Lys Arg Met Gln Gln Ile Met Ala His Cys Phe Leu Ala 
465                 470                 475                 480 


Ala Lys Pro Lys Leu Asp Cys Lys Leu Gly Tyr Phe Asp Leu Ile Gly 
                485                 490                 495     


Cys Asp Phe Leu Ile Asp Asp Asn Phe Lys Val Trp Leu Leu Glu Met 
            500                 505                 510         


Asn Ser Asn Pro Ala Leu His Thr Asn Cys Glu Val Leu Lys Glu Val 
        515                 520                 525             


Ile Pro Gly Val Val Ile Glu Thr Leu Asp Leu Val Leu Glu Thr Phe 
    530                 535                 540                 


Arg Lys Ser Leu Arg Gly Gln Lys Met Leu Pro Leu Leu Ser Gln Arg 
545                 550                 555                 560 


Arg Phe Val Leu Leu His Asn Gly Glu Ala Asp Pro Arg Pro His Leu 
                565                 570                 575     


Gly Gly Ser Cys Ser Leu Arg Arg Trp Pro Pro Leu Pro Thr Arg Gln 
            580                 585                 590         


Ala Lys Ser Ser Gly Pro Pro Met Pro His Ala Pro Asp Gln Pro Gly 
        595                 600                 605             


Ala Arg Arg Pro Ala Pro Pro Pro Leu Val Pro Gln Arg Pro Arg Pro 
    610                 615                 620                 


Pro Gly Pro Asp Leu Asp Ser Ala His Asp Gly Glu Pro Gln Ala Pro 
625                 630                 635                 640 


Gly Thr Glu Gln Ser Gly Thr Gly Asn Arg His Pro Ala Gln Glu Pro 
                645                 650                 655     


Ser Pro Gly Thr Ala Lys Glu Glu Arg Glu Glu Pro Glu Asn Ala Arg 
            660                 665                 670         


Pro 
    


<210> 6589
<211> 673
<212> PRT
<213> Homo sapiens

<400> 6589
Met Asp His Ser Cys Thr Arg Phe Ile His Arg Arg Gly Pro Pro Thr 
1               5                   10                  15      


Arg Thr Arg Ala Gly Phe Lys Arg Gly Lys Arg Pro Arg Ile Gln Gln 
            20                  25                  30          


Arg Pro Arg Ala Arg Val Ser Gly Thr Ile Pro Ala Ser Arg Leu His 
        35                  40                  45              


Pro Ala Pro Ala Ser Gln Pro Gly Pro Cys Pro Ala Pro Gly His Cys 
    50                  55                  60                  


Pro Val Gly Pro Ala His Glu Arg Pro Met Gly Ser Ser Gln Glu Glu 
65                  70                  75                  80  


Gly Leu Arg Cys Gln Pro Ser Gln Pro Asp His Asp Ala Asp Gly His 
                85                  90                  95      


Cys Gly Pro Asp Leu Glu Gly Ala Glu Arg Ala Ser Ala Thr Pro Gly 
            100                 105                 110         


Pro Pro Gly Leu Leu Asn Ser His Arg Pro Ala Asp Ser Asp Asp Thr 
        115                 120                 125             


Asn Ala Ala Gly Pro Ser Ala Ala Leu Leu Glu Gly Leu Leu Leu Gly 
    130                 135                 140                 


Gly Gly Lys Pro Ser Pro His Ser Thr Arg Pro Gly Pro Phe Phe Tyr 
145                 150                 155                 160 


Ile Gly Gly Ser Asn Gly Ala Thr Ile Ile Ser Ser Tyr Cys Lys Ser 
                165                 170                 175     


Lys Gly Trp Gln Arg Ile His Asp Ser Arg Arg Asp Asp Tyr Thr Leu 
            180                 185                 190         


Lys Trp Cys Glu Val Lys Ser Arg Asp Ser Tyr Gly Ser Phe Arg Glu 
        195                 200                 205             


Gly Glu Gln Leu Leu Tyr Gln Leu Pro Asn Asn Lys Leu Leu Thr Thr 
    210                 215                 220                 


Lys Ile Gly Leu Leu Ser Thr Leu Arg Gly Arg Ala Arg Ala Met Ser 
225                 230                 235                 240 


Lys Ala Ser Lys Val Pro Gly Gly Val Gln Ala Arg Leu Glu Lys Asp 
                245                 250                 255     


Ala Ala Ala Pro Ala Leu Glu Asp Leu Pro Trp Thr Ser Pro Gly Tyr 
            260                 265                 270         


Leu Arg Pro Gln Arg Val Leu Arg Met Glu Glu Phe Phe Pro Glu Thr 
        275                 280                 285             


Tyr Arg Leu Asp Leu Lys His Glu Arg Glu Ala Phe Phe Thr Leu Phe 
    290                 295                 300                 


Asp Glu Thr Gln Ile Trp Ile Cys Lys Pro Thr Ala Ser Asn Gln Gly 
305                 310                 315                 320 


Lys Gly Ile Phe Leu Leu Arg Asn Gln Glu Glu Val Ala Ala Leu Gln 
                325                 330                 335     


Ala Lys Thr Arg Ser Met Glu Asp Asp Pro Ile His His Lys Thr Pro 
            340                 345                 350         


Phe Arg Gly Pro Gln Ala Arg Val Val Gln Arg Tyr Ile Gln Asn Pro 
        355                 360                 365             


Leu Leu Val Asp Gly Arg Lys Phe Asp Val Arg Ser Tyr Leu Leu Ile 
    370                 375                 380                 


Ala Cys Thr Thr Pro Tyr Met Ile Phe Phe Gly His Gly Tyr Ala Arg 
385                 390                 395                 400 


Leu Thr Leu Ser Leu Tyr Asp Pro His Ser Ser Asp Leu Gly Gly His 
                405                 410                 415     


Leu Thr Asn Gln Phe Met Gln Lys Lys Ser Pro Leu Tyr Met Leu Leu 
            420                 425                 430         


Lys Glu His Thr Val Trp Ser Met Glu His Leu Asn Arg Tyr Ile Ser 
        435                 440                 445             


Asp Thr Phe Trp Lys Ala Arg Gly Leu Ala Lys Asp Trp Val Phe Thr 
    450                 455                 460                 


Thr Leu Lys Lys Arg Met Gln Gln Ile Met Ala His Cys Phe Leu Ala 
465                 470                 475                 480 


Ala Lys Pro Lys Leu Asp Cys Lys Leu Gly Tyr Phe Asp Leu Ile Gly 
                485                 490                 495     


Cys Asp Phe Leu Ile Asp Asp Asn Phe Lys Val Trp Leu Leu Glu Met 
            500                 505                 510         


Asn Ser Asn Pro Ala Leu His Thr Asn Cys Glu Val Leu Lys Glu Val 
        515                 520                 525             


Ile Pro Gly Val Val Ile Glu Thr Leu Asp Leu Val Leu Glu Thr Phe 
    530                 535                 540                 


Arg Lys Ser Leu Arg Gly Gln Lys Met Leu Pro Leu Leu Ser Gln Arg 
545                 550                 555                 560 


Arg Phe Val Leu Leu His Asn Gly Glu Ala Asp Pro Arg Pro His Leu 
                565                 570                 575     


Gly Gly Ser Cys Ser Leu Arg Arg Trp Pro Pro Leu Pro Thr Arg Gln 
            580                 585                 590         


Ala Lys Ser Ser Gly Pro Pro Met Pro His Ala Pro Asp Gln Pro Gly 
        595                 600                 605             


Ala Arg Arg Pro Ala Pro Pro Pro Leu Val Pro Gln Arg Pro Arg Pro 
    610                 615                 620                 


Pro Gly Pro Asp Leu Asp Ser Ala His Asp Gly Glu Pro Gln Ala Pro 
625                 630                 635                 640 


Gly Thr Glu Gln Ser Gly Thr Gly Asn Arg His Pro Ala Gln Glu Pro 
                645                 650                 655     


Ser Pro Gly Thr Ala Lys Glu Glu Arg Glu Glu Pro Glu Asn Ala Arg 
            660                 665                 670         


Pro 
    


<210> 6590
<211> 130
<212> PRT
<213> Homo sapiens

<400> 6590
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp 
    130 


<210> 6591
<211> 293
<212> PRT
<213> Homo sapiens

<400> 6591
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn 
145                 150                 155                 160 


Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala 
                165                 170                 175     


Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu 
            180                 185                 190         


Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys 
        195                 200                 205             


Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp 
    210                 215                 220                 


Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val 
225                 230                 235                 240 


Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn Ser Ala 
                245                 250                 255     


Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser Ser Asp 
            260                 265                 270         


Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys Gly Thr 
        275                 280                 285             


Pro Val His Ser Ser 
    290             


<210> 6592
<211> 266
<212> PRT
<213> Homo sapiens

<400> 6592
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala 
        35                  40                  45              


Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala 
    50                  55                  60                  


Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro 
                85                  90                  95      


Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys 
            100                 105                 110         


Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr 
        115                 120                 125             


Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro 
    130                 135                 140                 


Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr 
                165                 170                 175     


Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser 
            180                 185                 190         


Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu 
        195                 200                 205             


Val Phe Val Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met 
    210                 215                 220                 


Ala Leu Asn Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro 
225                 230                 235                 240 


Gln Asp Ser Ser Asp Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His 
                245                 250                 255     


Lys His Cys Gly Thr Pro Val His Ser Ser 
            260                 265     


<210> 6593
<211> 1223
<212> PRT
<213> Homo sapiens

<400> 6593
Met Met Ser Leu Ser Val Arg Pro Gln Arg Arg Leu Leu Ser Ala Arg 
1               5                   10                  15      


Val Asn Arg Ser Gln Ser Phe Ala Gly Val Leu Gly Ser His Glu Arg 
            20                  25                  30          


Gly Pro Ser Leu Ser Phe Arg Ser Phe Pro Val Phe Ser Pro Pro Gly 
        35                  40                  45              


Pro Pro Arg Lys Pro Pro Ala Leu Ser Arg Val Ser Arg Met Phe Ser 
    50                  55                  60                  


Val Ala His Pro Ala Ala Lys Val Pro Gln Pro Glu Arg Leu Asp Leu 
65                  70                  75                  80  


Val Tyr Thr Ala Leu Lys Arg Gly Leu Thr Ala Tyr Leu Glu Val His 
                85                  90                  95      


Gln Gln Glu Gln Glu Lys Leu Gln Gly Gln Ile Arg Glu Ser Lys Arg 
            100                 105                 110         


Asn Ser Arg Leu Gly Phe Leu Tyr Asp Leu Asp Lys Gln Val Lys Ser 
        115                 120                 125             


Ile Glu Arg Phe Leu Arg Arg Leu Glu Phe His Ala Ser Lys Ile Asp 
    130                 135                 140                 


Glu Leu Tyr Glu Ala Tyr Cys Val Gln Arg Arg Leu Arg Asp Gly Ala 
145                 150                 155                 160 


Tyr Asn Met Val Arg Ala Tyr Thr Thr Gly Ser Pro Gly Ser Arg Glu 
                165                 170                 175     


Ala Arg Asp Ser Leu Ala Glu Ala Thr Arg Gly His Arg Glu Tyr Thr 
            180                 185                 190         


Glu Ser Met Cys Leu Leu Glu Ser Glu Leu Glu Ala Gln Leu Gly Glu 
        195                 200                 205             


Phe His Leu Arg Met Lys Gly Leu Ala Gly Phe Ala Arg Leu Cys Val 
    210                 215                 220                 


Gly Asp Gln Tyr Glu Ile Cys Met Lys Tyr Gly Arg Gln Arg Trp Lys 
225                 230                 235                 240 


Leu Arg Gly Arg Ile Glu Gly Ser Gly Lys Gln Val Trp Asp Ser Glu 
                245                 250                 255     


Glu Thr Ile Phe Leu Pro Leu Leu Thr Glu Phe Leu Ser Ile Lys Val 
            260                 265                 270         


Thr Glu Leu Lys Gly Leu Ala Asn His Val Val Val Gly Ser Val Ser 
        275                 280                 285             


Cys Glu Thr Lys Asp Leu Phe Ala Ala Leu Pro Gln Val Val Ala Val 
    290                 295                 300                 


Asp Ile Asn Asp Leu Gly Thr Ile Lys Leu Ser Leu Glu Val Thr Trp 
305                 310                 315                 320 


Ser Pro Phe Asp Lys Asp Asp Gln Pro Ser Ala Ala Ser Ser Val Asn 
                325                 330                 335     


Lys Ala Ser Thr Val Thr Lys Arg Phe Ser Thr Tyr Ser Gln Ser Pro 
            340                 345                 350         


Pro Asp Thr Pro Ser Leu Arg Glu Gln Ala Phe Tyr Asn Met Leu Arg 
        355                 360                 365             


Arg Gln Glu Glu Leu Glu Asn Gly Thr Ala Trp Ser Leu Ser Ser Glu 
    370                 375                 380                 


Ser Ser Asp Asp Ser Ser Ser Pro Gln Leu Ser Gly Thr Ala Arg His 
385                 390                 395                 400 


Ser Pro Ala Pro Arg Pro Leu Val Gln Gln Pro Glu Pro Leu Pro Ile 
                405                 410                 415     


Gln Val Ala Phe Arg Arg Pro Glu Thr Pro Ser Ser Gly Pro Leu Asp 
            420                 425                 430         


Glu Glu Gly Ala Val Ala Pro Val Leu Ala Asn Gly His Ala Pro Tyr 
        435                 440                 445             


Ser Arg Thr Leu Ser His Ile Ser Glu Ala Ser Val Asp Ala Ala Leu 
    450                 455                 460                 


Ala Glu Ala Ser Val Glu Ala Val Gly Pro Glu Ser Leu Ala Trp Gly 
465                 470                 475                 480 


Pro Ser Pro Pro Thr His Pro Ala Pro Thr His Gly Glu His Pro Ser 
                485                 490                 495     


Pro Val Pro Pro Ala Leu Asp Pro Gly His Ser Ala Thr Ser Ser Thr 
            500                 505                 510         


Leu Gly Thr Thr Gly Ser Val Pro Thr Ser Thr Asp Pro Ala Pro Ser 
        515                 520                 525             


Ala His Leu Asp Ser Val His Lys Ser Thr Asp Ser Gly Pro Ser Glu 
    530                 535                 540                 


Leu Pro Gly Pro Thr His Thr Thr Thr Gly Ser Thr Tyr Ser Ala Ile 
545                 550                 555                 560 


Thr Thr Thr His Ser Ala Pro Ser Pro Leu Thr His Thr Thr Thr Gly 
                565                 570                 575     


Ser Thr His Lys Pro Ile Ile Ser Thr Leu Thr Thr Thr Gly Pro Thr 
            580                 585                 590         


Leu Asn Ile Ile Gly Pro Val Gln Thr Thr Thr Ser Pro Thr His Thr 
        595                 600                 605             


Met Pro Ser Pro Thr His Thr Thr Ala Ser Pro Thr His Thr Ser Thr 
    610                 615                 620                 


Ser Pro Thr His Thr Pro Thr Ser Pro Thr His Lys Thr Ser Met Ser 
625                 630                 635                 640 


Pro Pro Thr Thr Thr Ser Pro Thr Pro Ser Gly Met Gly Leu Val Gln 
                645                 650                 655     


Thr Ala Thr Ser Pro Thr His Pro Thr Thr Ser Pro Thr His Pro Thr 
            660                 665                 670         


Thr Ser Pro Ile Leu Ile Asn Val Ser Pro Ser Thr Ser Leu Glu Leu 
        675                 680                 685             


Ala Thr Leu Ser Ser Pro Ser Lys His Ser Asp Pro Thr Leu Pro Gly 
    690                 695                 700                 


Thr Asp Ser Leu Pro Cys Ser Pro Pro Val Ser Asn Ser Tyr Thr Gln 
705                 710                 715                 720 


Ala Asp Pro Met Ala Pro Arg Thr Pro His Pro Ser Pro Ala His Ser 
                725                 730                 735     


Ser Arg Lys Pro Leu Thr Ser Pro Ala Pro Asp Pro Ser Glu Ser Thr 
            740                 745                 750         


Val Gln Ser Leu Ser Pro Thr Pro Ser Pro Pro Thr Pro Ala Pro Gln 
        755                 760                 765             


His Ser Asp Leu Cys Leu Ala Met Ala Val Gln Thr Pro Val Pro Thr 
    770                 775                 780                 


Ala Ala Gly Gly Ser Gly Asp Arg Ser Leu Glu Glu Ala Leu Gly Ala 
785                 790                 795                 800 


Leu Met Ala Ala Leu Asp Asp Tyr Arg Gly Gln Phe Pro Glu Leu Gln 
                805                 810                 815     


Gly Leu Glu Gln Glu Val Thr Arg Leu Glu Ser Leu Leu Met Gln Arg 
            820                 825                 830         


Gln Gly Leu Thr Arg Ser Arg Ala Ser Ser Leu Ser Ile Thr Val Glu 
        835                 840                 845             


His Ala Leu Glu Ser Phe Ser Phe Leu Asn Glu Asp Glu Asp Glu Asp 
    850                 855                 860                 


Asn Asp Val Pro Gly Asp Arg Pro Pro Ser Ser Pro Glu Ala Gly Ala 
865                 870                 875                 880 


Glu Asp Ser Ile Asp Ser Pro Ser Ala Arg Pro Leu Ser Thr Gly Cys 
                885                 890                 895     


Pro Ala Leu Asp Ala Ala Leu Val Arg His Leu Tyr His Cys Ser Arg 
            900                 905                 910         


Leu Leu Leu Lys Leu Gly Thr Phe Gly Pro Leu Arg Cys Gln Glu Ala 
        915                 920                 925             


Trp Ala Leu Glu Arg Leu Leu Arg Glu Ala Arg Val Leu Glu Ala Val 
    930                 935                 940                 


Cys Glu Phe Ser Arg Arg Trp Glu Ile Pro Ala Ser Ser Ala Gln Glu 
945                 950                 955                 960 


Val Val Gln Phe Ser Ala Ser Arg Pro Gly Phe Leu Thr Phe Trp Asp 
                965                 970                 975     


Gln Cys Thr Glu Arg Leu Ser Cys Phe Leu Cys Pro Val Glu Arg Val 
            980                 985                 990         


Leu Leu Thr Phe Cys Asn Gln Tyr  Gly Ala Arg Leu Ser  Leu Arg Gln 
        995                 1000                 1005             


Pro Gly  Leu Ala Glu Ala Val  Cys Val Lys Phe Leu  Glu Asp Ala 
    1010                 1015                 1020             


Leu Gly  Gln Lys Leu Pro Arg  Arg Pro Gln Pro Gly  Pro Gly Glu 
    1025                 1030                 1035             


Gln Leu  Thr Val Phe Gln Phe  Trp Ser Phe Val Glu  Thr Leu Asp 
    1040                 1045                 1050             


Ser Pro  Thr Met Glu Ala Tyr  Val Thr Glu Thr Ala  Glu Glu Val 
    1055                 1060                 1065             


Leu Leu  Val Arg Asn Leu Asn  Ser Asp Asp Gln Ala  Val Val Leu 
    1070                 1075                 1080             


Lys Ala  Leu Arg Leu Ala Pro  Glu Gly Arg Leu Arg  Arg Asp Gly 
    1085                 1090                 1095             


Leu Arg  Ala Leu Ser Ser Leu  Leu Val His Gly Asn  Asn Lys Val 
    1100                 1105                 1110             


Met Ala  Ala Val Ser Thr Gln  Leu Arg Ser Leu Ser  Leu Gly Pro 
    1115                 1120                 1125             


Thr Phe  Arg Glu Arg Ala Leu  Leu Cys Phe Leu Asp  Gln Leu Glu 
    1130                 1135                 1140             


Asp Glu  Asp Val Gln Thr Arg  Val Ala Gly Cys Leu  Ala Leu Gly 
    1145                 1150                 1155             


Cys Ile  Lys Ala Pro Glu Gly  Ile Glu Pro Leu Val  Tyr Leu Cys 
    1160                 1165                 1170             


Gln Thr  Asp Thr Glu Ala Val  Arg Glu Ala Ala Arg  Gln Ser Leu 
    1175                 1180                 1185             


Gln Gln  Cys Gly Glu Glu Gly  Gln Ser Ala His Arg  Arg Leu Glu 
    1190                 1195                 1200             


Glu Ser  Leu Asp Ala Leu Pro  Arg Ile Phe Gly Pro  Gly Ser Met 
    1205                 1210                 1215             


Ala Ser  Thr Ala Phe 
    1220             


<210> 6594
<211> 40
<212> PRT
<213> Homo sapiens

<400> 6594
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu 
1               5                   10                  15      


Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala 
            20                  25                  30          


Lys His Ser Ser Thr Glu Glu Lys 
        35                  40  


<210> 6595
<211> 137
<212> PRT
<213> Homo sapiens

<400> 6595
Met Lys Pro Pro Ala Ala Gln Gly Ser Pro Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Ala Leu Asp Ser Ala Ala Ala Glu Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Cys Glu Phe Asp Ala Val Leu Ala Asp Phe Ala Ser Pro Phe His Glu 
        35                  40                  45              


Arg His Phe His Tyr Glu Glu His Leu Glu Arg Met Lys Arg Arg Ser 
    50                  55                  60                  


Ser Ala Ser Val Ser Asp Ser Ser Gly Phe Ser Asp Ser Glu Ser Ala 
65                  70                  75                  80  


Asp Ser Leu Tyr Arg Asn Ser Phe Ser Phe Ser Asp Glu Lys Leu Asn 
                85                  90                  95      


Ser Pro Thr Asp Ser Thr Pro Ala Leu Leu Ser Ala Thr Val Thr Pro 
            100                 105                 110         


Gln Lys Ala Lys Leu Gly Asp Thr Lys Glu Leu Glu Ala Phe Ile Ala 
        115                 120                 125             


Asp Leu Asp Lys Thr Leu Ala Ser Met 
    130                 135         


<210> 6596
<211> 530
<212> PRT
<213> Homo sapiens

<400> 6596
Met Pro Asn Val Leu Leu Pro Pro Lys Glu Ser Asn Leu Phe Lys Arg 
1               5                   10                  15      


Ile Leu Lys Cys Tyr Glu Gln Lys Gln Tyr Lys Asn Gly Leu Lys Phe 
            20                  25                  30          


Cys Lys Met Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr 
        35                  40                  45              


Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu 
    50                  55                  60                  


Ala Tyr Glu Phe Val Arg Lys Gly Leu Arg Asn Asp Val Lys Ser His 
65                  70                  75                  80  


Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr 
                85                  90                  95      


Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Leu Asp Lys Asp 
            100                 105                 110         


Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg 
        115                 120                 125             


Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg 
    130                 135                 140                 


Pro Thr Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu 
145                 150                 155                 160 


Leu Lys Asp Tyr Asp Met Ala Leu Lys Leu Leu Glu Glu Phe Arg Gln 
                165                 170                 175     


Thr Gln Gln Val Pro Pro Asn Lys Ile Asp Tyr Glu Tyr Ser Glu Leu 
            180                 185                 190         


Ile Leu Tyr Gln Asn Gln Val Met Arg Glu Ala Asp Leu Leu Gln Glu 
        195                 200                 205             


Ser Leu Glu His Ile Glu Met Tyr Glu Lys Gln Ile Cys Asp Lys Leu 
    210                 215                 220                 


Leu Val Glu Glu Ile Lys Gly Glu Ile Leu Leu Lys Leu Gly Arg Leu 
225                 230                 235                 240 


Lys Glu Ala Ser Glu Val Phe Lys Asn Leu Ile Asp Arg Asn Ala Glu 
                245                 250                 255     


Asn Trp Cys Tyr Tyr Glu Gly Leu Glu Lys Ala Leu Gln Ile Ser Thr 
            260                 265                 270         


Leu Glu Glu Arg Leu Gln Ile Tyr Glu Glu Ile Ser Lys Gln His Pro 
        275                 280                 285             


Lys Ala Ile Thr Pro Arg Arg Leu Pro Leu Thr Leu Val Pro Gly Glu 
    290                 295                 300                 


Arg Phe Arg Glu Leu Met Asp Lys Phe Leu Arg Val Asn Phe Ser Lys 
305                 310                 315                 320 


Gly Cys Pro Pro Leu Phe Thr Thr Leu Lys Ser Leu Tyr Tyr Asn Thr 
                325                 330                 335     


Glu Lys Val Ser Ile Ile Gln Glu Leu Val Thr Asn Tyr Glu Ala Ser 
            340                 345                 350         


Leu Lys Thr Cys Asp Phe Phe Ser Pro Tyr Glu Asn Gly Glu Lys Glu 
        355                 360                 365             


Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Phe Leu Ala Gln His Phe 
    370                 375                 380                 


Asp Lys Leu Gly Gln Tyr Ser Leu Ala Leu Asp Tyr Ile Asn Ala Ala 
385                 390                 395                 400 


Ile Ala Ser Thr Pro Thr Leu Ile Glu Leu Phe Tyr Met Lys Ala Lys 
                405                 410                 415     


Ile Tyr Lys His Ile Gly Asn Leu Lys Glu Ala Ala Lys Trp Met Asp 
            420                 425                 430         


Glu Ala Gln Ser Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
        435                 440                 445             


Ala Lys Tyr Met Leu Arg Ala Asn Met Ile Lys Glu Ala Glu Glu Met 
    450                 455                 460                 


Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Met Glu Asn Leu Asn 
465                 470                 475                 480 


Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ile Ser Ala Tyr Gln 
                485                 490                 495     


Arg Leu Gly Arg Tyr Gly Asp Ala Leu Lys Lys Cys His Glu Val Glu 
            500                 505                 510         


Arg His Ser Pro Ser Thr Trp Thr Thr Gly Gly Lys Glu Pro Gln Met 
        515                 520                 525             


His Pro 
    530 


<210> 6597
<211> 864
<212> PRT
<213> Homo sapiens

<400> 6597
Met Pro Asn Val Leu Leu Pro Pro Lys Glu Ser Asn Leu Phe Lys Arg 
1               5                   10                  15      


Ile Leu Lys Cys Tyr Glu Gln Lys Gln Tyr Lys Asn Gly Leu Lys Phe 
            20                  25                  30          


Cys Lys Met Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr 
        35                  40                  45              


Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu 
    50                  55                  60                  


Ala Tyr Glu Phe Val Arg Lys Gly Leu Arg Asn Asp Val Lys Ser His 
65                  70                  75                  80  


Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr 
                85                  90                  95      


Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Leu Asp Lys Asp 
            100                 105                 110         


Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg 
        115                 120                 125             


Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg 
    130                 135                 140                 


Pro Thr Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu 
145                 150                 155                 160 


Leu Lys Asp Tyr Asp Met Ala Leu Lys Leu Leu Glu Glu Phe Arg Gln 
                165                 170                 175     


Thr Gln Gln Val Pro Pro Asn Lys Ile Asp Tyr Glu Tyr Ser Glu Leu 
            180                 185                 190         


Ile Leu Tyr Gln Asn Gln Val Met Arg Glu Ala Asp Leu Leu Gln Glu 
        195                 200                 205             


Ser Leu Glu His Ile Glu Met Tyr Glu Lys Gln Ile Cys Asp Lys Leu 
    210                 215                 220                 


Leu Val Glu Glu Ile Lys Gly Glu Ile Leu Leu Lys Leu Gly Arg Leu 
225                 230                 235                 240 


Lys Glu Ala Ser Glu Val Phe Lys Asn Leu Ile Asp Arg Asn Ala Glu 
                245                 250                 255     


Asn Trp Cys Tyr Tyr Glu Gly Leu Glu Lys Ala Leu Gln Ile Ser Thr 
            260                 265                 270         


Leu Glu Glu Arg Leu Gln Ile Tyr Glu Glu Ile Ser Lys Gln His Pro 
        275                 280                 285             


Lys Ala Ile Thr Pro Arg Arg Leu Pro Leu Thr Leu Val Pro Gly Glu 
    290                 295                 300                 


Arg Phe Arg Glu Leu Met Asp Lys Phe Leu Arg Val Asn Phe Ser Lys 
305                 310                 315                 320 


Gly Cys Pro Pro Leu Phe Thr Thr Leu Lys Ser Leu Tyr Tyr Asn Thr 
                325                 330                 335     


Glu Lys Val Ser Ile Ile Gln Glu Leu Val Thr Asn Tyr Glu Ala Ser 
            340                 345                 350         


Leu Lys Thr Cys Asp Phe Phe Ser Pro Tyr Glu Asn Gly Glu Lys Glu 
        355                 360                 365             


Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Phe Leu Ala Gln His Phe 
    370                 375                 380                 


Asp Lys Leu Gly Gln Tyr Ser Leu Ala Leu Asp Tyr Ile Asn Ala Ala 
385                 390                 395                 400 


Ile Ala Ser Thr Pro Thr Leu Ile Glu Leu Phe Tyr Met Lys Ala Lys 
                405                 410                 415     


Ile Tyr Lys His Ile Gly Asn Leu Lys Glu Ala Ala Lys Trp Met Asp 
            420                 425                 430         


Glu Ala Gln Ser Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
        435                 440                 445             


Ala Lys Tyr Met Leu Arg Ala Asn Met Ile Lys Glu Ala Glu Glu Met 
    450                 455                 460                 


Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Met Glu Asn Leu Asn 
465                 470                 475                 480 


Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ile Ser Ala Tyr Gln 
                485                 490                 495     


Arg Leu Gly Arg Tyr Gly Asp Ala Leu Lys Lys Cys His Glu Val Glu 
            500                 505                 510         


Arg His Phe Phe Glu Ile Thr Asp Asp Gln Phe Asp Phe His Thr Tyr 
        515                 520                 525             


Cys Met Arg Lys Met Thr Leu Arg Ala Tyr Val Asp Leu Leu Arg Leu 
    530                 535                 540                 


Glu Asp Ile Leu Arg Arg His Ala Phe Tyr Phe Lys Ala Ala Arg Ser 
545                 550                 555                 560 


Ala Ile Glu Ile Tyr Leu Lys Leu Tyr Asp Asn Pro Leu Thr Asn Glu 
                565                 570                 575     


Ser Lys Gln Gln Glu Ile Asn Ser Glu Asn Leu Ser Ala Lys Glu Leu 
            580                 585                 590         


Lys Lys Met Leu Ser Lys Gln Arg Arg Ala Gln Lys Lys Ala Lys Leu 
        595                 600                 605             


Glu Glu Glu Arg Lys His Ala Glu Arg Glu Arg Gln Gln Lys Asn Gln 
    610                 615                 620                 


Lys Lys Lys Arg Asp Glu Glu Glu Glu Glu Ala Ser Gly Leu Lys Glu 
625                 630                 635                 640 


Glu Leu Ile Pro Glu Lys Leu Glu Arg Val Glu Asn Pro Leu Glu Glu 
                645                 650                 655     


Ala Val Lys Phe Leu Ile Pro Leu Lys Asn Leu Val Ala Asp Asn Ile 
            660                 665                 670         


Asp Thr His Leu Leu Ala Phe Glu Ile Tyr Phe Arg Lys Gly Lys Phe 
        675                 680                 685             


Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asn Ser Asn 
    690                 695                 700                 


Asn Pro Trp Leu His Glu Cys Leu Ile Arg Phe Ser Lys Ser Val Ser 
705                 710                 715                 720 


Asn His Ser Asn Leu Pro Asp Ile Val Ser Lys Val Leu Ser Gln Glu 
                725                 730                 735     


Met Gln Lys Ile Phe Val Lys Lys Asp Leu Glu Ser Phe Asn Glu Asp 
            740                 745                 750         


Phe Leu Lys Arg Asn Ala Thr Ser Leu Gln His Leu Leu Ser Gly Ala 
        755                 760                 765             


Lys Met Met Tyr Phe Leu Asp Lys Ser Arg Gln Glu Lys Ala Ile Ala 
    770                 775                 780                 


Ile Ala Thr Arg Leu Asp Glu Thr Ile Lys Asp Lys Asp Val Lys Thr 
785                 790                 795                 800 


Leu Ile Lys Val Ser Glu Ala Leu Leu Asp Gly Ser Phe Gly Asn Cys 
                805                 810                 815     


Ser Ser Gln Tyr Glu Glu Tyr Arg Met Ala Cys His Asn Leu Leu Pro 
            820                 825                 830         


Phe Thr Ser Ala Phe Leu Pro Ala Val Asn Glu Val Asp Asn Pro Asn 
        835                 840                 845             


Val Ala Leu Asn His Thr Ala Asn Tyr Asp Val Leu Ala Asn Glu Ile 
    850                 855                 860                 


<210> 6598
<211> 555
<212> PRT
<213> Homo sapiens

<400> 6598
Met Gln Ser Cys Glu Ser Ser Gly Asp Ser Ala Asp Asp Pro Leu Ser 
1               5                   10                  15      


Arg Gly Leu Arg Arg Arg Gly Gln Pro Arg Val Val Val Ile Gly Ala 
            20                  25                  30          


Gly Leu Ala Gly Leu Ala Ala Ala Lys Ala Leu Leu Glu Gln Gly Phe 
        35                  40                  45              


Thr Asp Val Thr Val Leu Glu Ala Ser Ser His Ile Gly Gly Arg Val 
    50                  55                  60                  


Gln Ser Val Lys Leu Gly His Ala Thr Phe Glu Leu Gly Ala Thr Trp 
65                  70                  75                  80  


Ile His Gly Ser His Gly Asn Pro Ile Tyr His Leu Ala Glu Ala Asn 
                85                  90                  95      


Gly Leu Leu Glu Glu Thr Thr Asp Gly Glu Arg Ser Val Gly Arg Ile 
            100                 105                 110         


Ser Leu Tyr Ser Lys Asn Gly Val Ala Cys Tyr Leu Thr Asn His Gly 
        115                 120                 125             


Arg Arg Ile Pro Lys Asp Val Val Glu Glu Phe Ser Asp Leu Tyr Asn 
    130                 135                 140                 


Glu Val Tyr Asn Leu Thr Gln Glu Phe Phe Arg His Asp Lys Pro Val 
145                 150                 155                 160 


Asn Ala Glu Ser Gln Asn Ser Val Gly Val Phe Thr Arg Glu Glu Val 
                165                 170                 175     


Arg Asn Arg Ile Arg Asn Asp Pro Asp Asp Pro Glu Ala Thr Lys Arg 
            180                 185                 190         


Leu Lys Leu Ala Met Ile Gln Gln Tyr Leu Lys Val Glu Ser Cys Glu 
        195                 200                 205             


Ser Ser Ser His Ser Met Asp Glu Val Ser Leu Ser Ala Phe Gly Glu 
    210                 215                 220                 


Trp Thr Glu Ile Pro Gly Ala His His Ile Ile Pro Ser Gly Phe Met 
225                 230                 235                 240 


Arg Val Val Glu Leu Leu Ala Glu Gly Ile Pro Ala His Val Ile Gln 
                245                 250                 255     


Leu Gly Lys Pro Val Arg Cys Ile His Trp Asp Gln Ala Ser Ala Arg 
            260                 265                 270         


Pro Arg Gly Pro Glu Ile Glu Pro Arg Gly Glu Gly Asp His Asn His 
        275                 280                 285             


Asp Thr Gly Glu Gly Gly Gln Gly Gly Glu Glu Pro Arg Gly Gly Arg 
    290                 295                 300                 


Trp Asp Glu Asp Glu Gln Trp Ser Val Val Val Glu Cys Glu Asp Cys 
305                 310                 315                 320 


Glu Leu Ile Pro Ala Asp His Val Ile Val Thr Val Ser Leu Gly Val 
                325                 330                 335     


Leu Lys Arg Gln Tyr Thr Ser Phe Phe Arg Pro Gly Leu Pro Thr Glu 
            340                 345                 350         


Lys Val Ala Ala Ile His Arg Leu Gly Ile Gly Thr Thr Asp Lys Ile 
        355                 360                 365             


Phe Leu Glu Phe Glu Glu Pro Phe Trp Gly Pro Glu Cys Asn Ser Leu 
    370                 375                 380                 


Gln Phe Val Trp Glu Asp Glu Ala Glu Ser His Thr Leu Thr Tyr Pro 
385                 390                 395                 400 


Pro Glu Leu Trp Tyr Arg Lys Ile Cys Gly Phe Asp Val Leu Tyr Pro 
                405                 410                 415     


Pro Glu Arg Tyr Gly His Val Leu Ser Gly Trp Ile Cys Gly Glu Glu 
            420                 425                 430         


Ala Leu Val Met Glu Lys Cys Asp Asp Glu Ala Val Ala Glu Ile Cys 
        435                 440                 445             


Thr Glu Met Leu Arg Gln Phe Thr Gly Asn Pro Asn Ile Pro Lys Pro 
    450                 455                 460                 


Arg Arg Ile Leu Arg Ser Ala Trp Gly Ser Asn Pro Tyr Phe Arg Gly 
465                 470                 475                 480 


Ser Tyr Ser Tyr Thr Gln Val Gly Ser Ser Gly Ala Asp Val Glu Lys 
                485                 490                 495     


Leu Ala Lys Pro Leu Pro Tyr Thr Glu Ser Ser Lys Thr Ala Pro Met 
            500                 505                 510         


Gln Val Leu Phe Ser Gly Glu Ala Thr His Arg Lys Tyr Tyr Ser Thr 
        515                 520                 525             


Thr His Gly Ala Leu Leu Ser Gly Gln Arg Glu Ala Ala Arg Leu Ile 
    530                 535                 540                 


Glu Met Tyr Arg Asp Leu Phe Gln Gln Gly Thr 
545                 550                 555 


<210> 6599
<211> 209
<212> PRT
<213> Homo sapiens

<400> 6599
Met Ala Pro Val Gly Val Glu Lys Lys Leu Leu Leu Gly Pro Asn Gly 
1               5                   10                  15      


Pro Ala Val Ala Ala Ala Gly Asp Leu Thr Ser Glu Glu Glu Glu Gly 
            20                  25                  30          


Gln Ser Leu Trp Ser Ser Ile Leu Ser Glu Val Ser Thr Arg Ala Arg 
        35                  40                  45              


Ser Lys Leu Pro Ser Gly Lys Asn Ile Leu Val Phe Gly Glu Asp Gly 
    50                  55                  60                  


Ser Gly Lys Thr Thr Leu Met Thr Lys Leu Gln Gly Ala Glu His Gly 
65                  70                  75                  80  


Lys Lys Gly Arg Gly Leu Glu Tyr Leu Tyr Leu Ser Val His Asp Glu 
                85                  90                  95      


Asp Arg Asp Asp His Thr Arg Cys Asn Val Trp Ile Leu Asp Gly Asp 
            100                 105                 110         


Leu Tyr His Lys Gly Leu Leu Lys Phe Ala Val Ser Ala Glu Ser Leu 
        115                 120                 125             


Pro Glu Thr Leu Val Ile Phe Val Ala Asp Met Ser Arg Pro Trp Thr 
    130                 135                 140                 


Val Met Glu Ser Leu Gln Lys Trp Ala Ser Val Leu Arg Glu His Ile 
145                 150                 155                 160 


Asp Lys Met Lys Ile Pro Pro Glu Lys Met Arg Glu Leu Glu Arg Lys 
                165                 170                 175     


Phe Val Lys Asp Phe Gln Asp Tyr Met Glu Pro Glu Glu Gly Cys Gln 
            180                 185                 190         


Glu Gly Pro Leu Ser Asn Arg Val Glu Gln Met Arg Pro Arg Asn His 
        195                 200                 205             


Trp 
    


<210> 6600
<211> 285
<212> PRT
<213> Homo sapiens

<400> 6600
Asn Trp Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys Leu Leu 
1               5                   10                  15      


Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln Cys Ser 
            20                  25                  30          


Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr Leu Leu 
        35                  40                  45              


Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly Lys Lys 
    50                  55                  60                  


Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys Leu Pro 
65                  70                  75                  80  


Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val Asn Glu 
                85                  90                  95      


Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu Asp Thr 
            100                 105                 110         


Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg Ile Glu 
        115                 120                 125             


His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe Pro Gly 
    130                 135                 140                 


Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu Leu Thr 
145                 150                 155                 160 


Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg Glu Tyr 
                165                 170                 175     


Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu Tyr Asp 
            180                 185                 190         


Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys Asp Phe 
        195                 200                 205             


Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg Asp Gln 
    210                 215                 220                 


Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser Gly Gln 
225                 230                 235                 240 


Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg Trp Asp 
                245                 250                 255     


Gly Asn Glu Met Ala Lys Arg Ala Lys Ala Tyr Phe Lys Thr Phe Val 
            260                 265                 270         


Pro Gln Phe Gln Glu Ala Ala Phe Ala Asn Gly Lys Leu 
        275                 280                 285 


<210> 6601
<211> 383
<212> PRT
<213> Homo sapiens

<400> 6601
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 
            20                  25                  30          


Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Ala Tyr Phe Lys Thr 
        355                 360                 365             


Phe Val Pro Gln Phe Gln Glu Ala Ala Phe Ala Asn Gly Lys Leu 
    370                 375                 380             


<210> 6602
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6602
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 
            20                  25                  30          


Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Arg Glu Ser Asn Arg 
        355                 360                 365             


Asp Gly Glu Glu Ser Ser Ser Ala 
    370                 375     


<210> 6603
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6603
Met Ile Arg Ala Phe Pro Thr Thr Thr Pro Arg Ser Leu His Leu Phe 
1               5                   10                  15      


Thr Ser Ser Thr Phe Leu Ala Arg Ala Leu Pro Gly Ala Phe Pro Thr 
            20                  25                  30          


Gly Ala Cys Glu Glu Arg Leu Ser Val Pro Glu Ser Thr Pro Phe Thr 
        35                  40                  45              


Ala Val Leu Lys Phe Ala Ala Glu Glu Phe Lys Val Pro Ala Ala Thr 
    50                  55                  60                  


Ser Ala Ile Ile Thr Asn Asp Gly Ile Gly Ile Asn Pro Ala Gln Thr 
65                  70                  75                  80  


Ala Gly Asn Val Phe Leu Lys His Gly Ser Glu Leu Arg Ile Ile Pro 
                85                  90                  95      


Arg Asp Arg Val Gly Ser Cys 
            100             


<210> 6604
<211> 655
<212> PRT
<213> Homo sapiens

<400> 6604
Met Ala Thr Pro Val Val Thr Lys Thr Ala Trp Lys Leu Gln Glu Ile 
1               5                   10                  15      


Val Ala His Ala Ser Asn Val Ser Ser Leu Val Leu Gly Lys Ala Ser 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Gly Gly Asp Asp Cys Arg Val Asn Leu Trp 
        35                  40                  45              


Ser Ile Asn Lys Pro Asn Cys Ile Met Ser Leu Thr Gly His Thr Ser 
    50                  55                  60                  


Pro Val Glu Ser Val Arg Leu Asn Thr Pro Glu Glu Leu Ile Val Ala 
65                  70                  75                  80  


Gly Ser Gln Ser Gly Ser Ile Arg Val Trp Asp Leu Glu Ala Ala Lys 
                85                  90                  95      


Ile Leu Arg Thr Leu Met Gly His Lys Ala Asn Ile Cys Ser Leu Asp 
            100                 105                 110         


Phe His Pro Tyr Gly Glu Phe Val Ala Ser Gly Ser Gln Asp Thr Asn 
        115                 120                 125             


Ile Lys Leu Trp Asp Ile Arg Arg Lys Gly Cys Val Phe Arg Tyr Arg 
    130                 135                 140                 


Gly His Ser Gln Ala Val Arg Cys Leu Arg Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Trp Leu Ala Ser Ala Ala Asp Asp His Thr Val Lys Leu Trp Asp Leu 
                165                 170                 175     


Thr Ala Gly Lys Met Met Ser Glu Phe Pro Gly His Thr Gly Pro Val 
            180                 185                 190         


Asn Val Val Glu Phe His Pro Asn Glu Tyr Leu Leu Ala Ser Gly Ser 
        195                 200                 205             


Ser Asp Arg Thr Ile Arg Phe Trp Asp Leu Glu Lys Phe Gln Val Val 
    210                 215                 220                 


Ser Cys Ile Glu Gly Glu Pro Gly Pro Val Arg Ser Val Leu Phe Asn 
225                 230                 235                 240 


Pro Asp Gly Cys Cys Leu Tyr Ser Gly Cys Gln Asp Ser Leu Arg Val 
                245                 250                 255     


Tyr Gly Trp Glu Pro Glu Arg Cys Phe Asp Val Val Leu Val Asn Trp 
            260                 265                 270         


Gly Lys Val Ala Asp Leu Ala Ile Cys Asn Asp Gln Leu Ile Gly Val 
        275                 280                 285             


Ala Phe Ser Gln Ser Asn Val Ser Ser Tyr Val Val Asp Leu Thr Arg 
    290                 295                 300                 


Val Thr Arg Thr Gly Thr Val Ala Arg Asp Pro Val Gln Asp His Arg 
305                 310                 315                 320 


Pro Leu Ala Gln Pro Leu Pro Asn Pro Ser Ala Pro Leu Arg Arg Ile 
                325                 330                 335     


Tyr Glu Arg Pro Ser Thr Thr Cys Ser Lys Pro Gln Arg Val Lys Gln 
            340                 345                 350         


Asn Ser Glu Ser Glu Arg Arg Ser Pro Ser Ser Glu Asp Asp Arg Asp 
        355                 360                 365             


Glu Arg Glu Ser Arg Ala Glu Ile Gln Asn Ala Glu Asp Tyr Asn Glu 
    370                 375                 380                 


Ile Phe Gln Pro Lys Asn Ser Ile Ser Arg Thr Pro Pro Arg Arg Ser 
385                 390                 395                 400 


Glu Pro Phe Pro Ala Pro Pro Glu Asp Asp Ala Ala Thr Ala Lys Glu 
                405                 410                 415     


Ala Ala Lys Pro Ser Pro Ala Met Asp Val Gln Phe Pro Val Pro Asn 
            420                 425                 430         


Leu Glu Val Leu Pro Arg Pro Pro Val Val Ala Ser Thr Pro Ala Pro 
        435                 440                 445             


Lys Ala Glu Pro Ala Ile Ile Pro Ala Thr Arg Asn Glu Pro Ile Gly 
    450                 455                 460                 


Leu Lys Ala Ser Asp Phe Leu Pro Ala Val Lys Ile Pro Gln Gln Ala 
465                 470                 475                 480 


Glu Leu Val Asp Glu Asp Ala Met Ser Gln Ile Arg Lys Gly His Asp 
                485                 490                 495     


Thr Met Cys Val Val Leu Thr Ser Arg His Lys Asn Leu Asp Thr Val 
            500                 505                 510         


Arg Ala Val Trp Thr Met Gly Asp Ile Lys Thr Ser Val Asp Ser Ala 
        515                 520                 525             


Val Ala Ile Asn Asp Leu Ser Val Val Val Asp Leu Leu Asn Ile Val 
    530                 535                 540                 


Asn Gln Lys Ala Ser Leu Trp Lys Leu Asp Leu Cys Thr Thr Val Leu 
545                 550                 555                 560 


Pro Gln Ile Glu Lys Leu Leu Gln Ser Lys Tyr Glu Ser Tyr Val Gln 
                565                 570                 575     


Thr Gly Cys Thr Ser Leu Lys Leu Ile Leu Gln Arg Phe Leu Pro Leu 
            580                 585                 590         


Ile Thr Asp Met Leu Ala Ala Pro Pro Ser Val Gly Val Asp Ile Ser 
        595                 600                 605             


Arg Glu Glu Arg Leu His Lys Cys Arg Leu Cys Tyr Lys Gln Leu Lys 
    610                 615                 620                 


Ser Ile Ser Gly Leu Val Lys Ser Lys Ser Gly Leu Ser Gly Arg His 
625                 630                 635                 640 


Gly Ser Thr Phe Arg Glu Leu His Leu Leu Met Ala Ser Leu Asp 
                645                 650                 655 


<210> 6605
<211> 54
<212> PRT
<213> Homo sapiens

<400> 6605
Met Phe Leu Ser Ala Val Phe Phe Ala Lys Ser Lys Ser Asn Glu Thr 
1               5                   10                  15      


Lys Ser Pro Leu Arg Gly Lys Glu Lys Asn Thr Leu Pro Leu Asn Gly 
            20                  25                  30          


Gly Leu Lys Met Thr Leu Ile Tyr Lys Glu Lys Thr Glu Gly Gly Asp 
        35                  40                  45              


Thr Asp Ser Glu Ile Leu 
    50                  


<210> 6606
<211> 818
<212> PRT
<213> Homo sapiens

<400> 6606
Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Thr Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Thr Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Thr His Lys 
        35                  40                  45              


Lys Leu Thr Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Thr Thr Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Thr Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Thr Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Thr Arg Trp Gln Gln Thr Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Thr Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Thr Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Thr Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Thr Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Thr Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Thr Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Thr Glu Met Met Thr Thr Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Thr Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Thr 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Leu Arg Lys Ile 
            500                 505                 510         


Gln Ser Met Gly Val Arg Val Met Asp Thr Asn Trp Val Ala Arg Arg 
        515                 520                 525             


Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro Pro Ser Met Gln 
    530                 535                 540                 


Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser 
                565                 570                 575     


Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Thr Ser Thr Thr Lys Ser 
            580                 585                 590         


Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser 
        595                 600                 605             


Gln Gly Thr Ala Cys Ala Gly Thr Gln Pro Gly Ala Gln Pro Gly Ala 
    610                 615                 620                 


Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser 
625                 630                 635                 640 


Pro His Thr Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile Pro Pro 
                645                 650                 655     


Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser Ala Gly 
            660                 665                 670         


Gln Pro Ser Pro Val Ser Leu Ser Pro Thr Pro Pro Ser Thr Pro Ser 
        675                 680                 685             


Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln 
    690                 695                 700                 


Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val Phe Thr 
705                 710                 715                 720 


Ser Thr Leu Ser Lys Ser Arg Pro Thr Pro Lys Pro Arg Gln Arg Pro 
                725                 730                 735     


Thr Leu Pro Pro Pro Gln Pro Pro Thr Val Asn Leu Ser Ala Ser Ser 
            740                 745                 750         


Pro Gln Ser Thr Glu Ala Pro Met Leu Asp Gly Met Ser Pro Gly Glu 
        755                 760                 765             


Ser Met Ser Thr Asp Leu Val His Phe Asp Ile Pro Ser Ile His Ile 
    770                 775                 780                 


Glu Leu Gly Ser Thr Leu Arg Leu Ser Pro Leu Glu His Met Arg Arg 
785                 790                 795                 800 


His Ser Val Thr Asp Lys Arg Asp Ser Glu Glu Glu Ser Glu Ser Thr 
                805                 810                 815     


Ala Leu 
        


<210> 6607
<211> 337
<212> PRT
<213> Homo sapiens

<400> 6607
Met Thr Asn Asn Ser Gly Ser Lys Ala Glu Leu Val Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Val Tyr 
            20                  25                  30          


Leu Gly Ile Thr Thr Thr Asn Gly Glu Asp Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Val Lys His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Thr Ile Leu Gln Gly Gly Val Gly Ile Pro His Met His Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Asn Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Leu His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Thr Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys His Leu Ile Gly Thr Val Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Phe Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Arg Ala Met Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Val Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Gln Thr Gly Lys Gln Thr Glu Lys Asn Lys Asn Asn Val Lys Asp 
                325                 330                 335     


Asn 
    


<210> 6608
<211> 535
<212> PRT
<213> Homo sapiens

<400> 6608
Met Ser Glu Gly Glu Ser Gln Thr Val Leu Ser Ser Gly Ser Asp Pro 
1               5                   10                  15      


Lys Val Glu Ser Ser Ser Ser Ala Pro Gly Leu Thr Ser Val Ser Pro 
            20                  25                  30          


Pro Val Thr Ser Thr Thr Ser Ala Ala Ser Pro Glu Glu Glu Glu Glu 
        35                  40                  45              


Ser Glu Asp Glu Ser Glu Ile Leu Glu Glu Ser Pro Cys Gly Arg Trp 
    50                  55                  60                  


Gln Lys Arg Arg Glu Glu Val Asn Gln Arg Asn Val Pro Gly Ile Asp 
65                  70                  75                  80  


Ser Ala Tyr Leu Ala Met Asp Thr Glu Glu Gly Val Glu Val Val Trp 
                85                  90                  95      


Asn Glu Val Gln Phe Ser Glu Arg Lys Asn Tyr Lys Leu Gln Glu Glu 
            100                 105                 110         


Lys Val Arg Ala Val Phe Asp Asn Leu Ile Gln Leu Glu His Leu Asn 
        115                 120                 125             


Ile Val Lys Phe His Lys Tyr Trp Ala Asp Ile Lys Glu Asn Lys Ala 
    130                 135                 140                 


Arg Val Ile Phe Ile Thr Glu Tyr Met Ser Ser Gly Ser Leu Lys Gln 
145                 150                 155                 160 


Phe Leu Lys Lys Thr Lys Lys Asn His Lys Thr Met Asn Glu Lys Ala 
                165                 170                 175     


Trp Lys Arg Trp Cys Thr Gln Ile Leu Ser Ala Leu Ser Tyr Leu His 
            180                 185                 190         


Ser Cys Asp Pro Pro Ile Ile His Gly Asn Leu Thr Cys Asp Thr Ile 
        195                 200                 205             


Phe Ile Gln His Asn Gly Leu Ile Lys Ile Gly Ser Val Ala Pro Asp 
    210                 215                 220                 


Thr Ile Asn Asn His Val Lys Thr Cys Arg Glu Glu Gln Lys Asn Leu 
225                 230                 235                 240 


His Phe Phe Ala Pro Glu Tyr Gly Glu Val Thr Asn Val Thr Thr Ala 
                245                 250                 255     


Val Asp Ile Tyr Ser Phe Gly Met Cys Ala Leu Glu Met Ala Val Leu 
            260                 265                 270         


Glu Ile Gln Gly Asn Gly Glu Ser Ser Tyr Val Pro Gln Glu Ala Ile 
        275                 280                 285             


Ser Ser Ala Ile Gln Leu Leu Glu Asp Pro Leu Gln Arg Glu Phe Ile 
    290                 295                 300                 


Gln Lys Cys Leu Gln Ser Glu Pro Ala Arg Arg Pro Thr Ala Arg Glu 
305                 310                 315                 320 


Leu Leu Phe His Pro Ala Leu Phe Glu Val Pro Ser Leu Lys Leu Leu 
                325                 330                 335     


Ala Ala His Cys Ile Val Gly His Gln His Met Ile Pro Glu Asn Ala 
            340                 345                 350         


Leu Glu Glu Ile Thr Lys Asn Met Asp Thr Ser Ala Val Leu Ala Glu 
        355                 360                 365             


Ile Pro Ala Gly Pro Gly Arg Glu Pro Val Gln Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Ser Pro Ala Leu Glu Leu Asp Lys Phe Leu Glu Asp Val Arg Asn Gly 
385                 390                 395                 400 


Ile Tyr Pro Leu Thr Ala Phe Gly Leu Pro Arg Pro Gln Gln Pro Gln 
                405                 410                 415     


Gln Glu Glu Val Thr Ser Pro Val Val Pro Pro Ser Val Lys Thr Pro 
            420                 425                 430         


Thr Pro Glu Pro Ala Glu Val Glu Thr Arg Lys Val Val Leu Met Gln 
        435                 440                 445             


Cys Asn Ile Glu Ser Val Glu Glu Gly Val Lys His His Leu Thr Leu 
    450                 455                 460                 


Leu Leu Lys Leu Glu Asp Lys Leu Asn Arg His Leu Ser Cys Asp Leu 
465                 470                 475                 480 


Met Pro Asn Glu Asn Ile Pro Glu Leu Ala Ala Glu Leu Val Gln Leu 
                485                 490                 495     


Gly Phe Ile Ser Glu Ala Asp Gln Ser Arg Leu Thr Ser Leu Leu Glu 
            500                 505                 510         


Glu Thr Leu Asn Lys Phe Asn Phe Ala Arg Asn Ser Thr Leu Asn Ser 
        515                 520                 525             


Ala Ala Val Thr Val Ser Ser 
    530                 535 


<210> 6609
<211> 722
<212> PRT
<213> Homo sapiens

<400> 6609
Met Glu Thr Ser Asp Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys 
1               5                   10                  15      


Gln Asn Leu Ser Glu Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr 
            20                  25                  30          


Asn Leu Tyr Ser Pro Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala 
        35                  40                  45              


Leu Pro Ala Met Lys Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly 
    50                  55                  60                  


Cys Gly Lys Thr Phe Val Ser Leu Leu Ile Cys Glu His His Leu Lys 
65                  70                  75                  80  


Lys Phe Pro Gln Gly Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln 
                85                  90                  95      


Ile Pro Val Tyr Glu Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu 
            100                 105                 110         


Arg His Gly Tyr Arg Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn 
        115                 120                 125             


Val Pro Val Glu Gln Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr 
    130                 135                 140                 


Pro Gln Ile Leu Val Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu 
145                 150                 155                 160 


Ser Ile Phe Thr Leu Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys 
                165                 170                 175     


Gln His Pro Tyr Asn Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu 
            180                 185                 190         


Gly Gly Ser Ser Gly Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser 
        195                 200                 205             


Val Gly Val Gly Asp Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile 
    210                 215                 220                 


Cys Lys Leu Cys Ala Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys 
225                 230                 235                 240 


His Asn Leu Glu Glu Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe 
                245                 250                 255     


Phe Arg Lys Val Glu Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile 
            260                 265                 270         


Ala Gln Leu Met Arg Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys 
        275                 280                 285             


Asp Leu Glu Asn Leu Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln 
    290                 295                 300                 


Lys Tyr Glu Gln Trp Ile Val Thr Val Gln Lys Ala Cys Met Val Phe 
305                 310                 315                 320 


Gln Met Pro Asp Lys Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe 
                325                 330                 335     


Leu Tyr Thr Ser His Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser 
            340                 345                 350         


Glu His Ala Arg Met Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe 
        355                 360                 365             


Ser Asn Val Arg Ala Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr 
    370                 375                 380                 


Gln Arg Phe Glu Glu Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp 
385                 390                 395                 400 


Pro Ser Asn Glu Asn Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln 
                405                 410                 415     


Glu Glu Tyr His Leu Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys 
            420                 425                 430         


Thr Arg Ala Leu Val Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro 
        435                 440                 445             


Lys Leu Ser Phe Leu Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr 
    450                 455                 460                 


Asn Gln Asn Thr Gly Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp 
465                 470                 475                 480 


Ala Phe Lys Ala Ser Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val 
                485                 490                 495     


Ala Asp Glu Gly Ile Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr 
            500                 505                 510         


Glu Tyr Val Gly Asn Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly 
        515                 520                 525             


Arg Ala Arg Gly Ser Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val 
    530                 535                 540                 


Ile Glu Lys Glu Gln Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp 
545                 550                 555                 560 


Ser Ile Leu Arg Leu Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys 
                565                 570                 575     


Ile Leu His Ile Gln Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu 
            580                 585                 590         


Lys Pro Lys Pro Val Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg 
        595                 600                 605             


Lys Cys Lys Ala Leu Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu 
    610                 615                 620                 


Glu Cys His Tyr Thr Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val 
625                 630                 635                 640 


Ser Arg Pro His Pro Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg 
                645                 650                 655     


Ala Lys Ile Phe Cys Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile 
            660                 665                 670         


His Val Lys Tyr Lys Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser 
        675                 680                 685             


Phe Val Val Glu Asp Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys 
    690                 695                 700                 


Trp Lys Asp Phe His Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met 
705                 710                 715                 720 


Ser Lys 
        


<210> 6610
<211> 880
<212> PRT
<213> Homo sapiens

<400> 6610
Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp 
        35                  40                  45              


Phe Lys Lys Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg 
    50                  55                  60                  


Leu Gln Pro Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser 
65                  70                  75                  80  


Asp Leu Ser Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln 
                85                  90                  95      


Ile Cys Ser Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu 
            100                 105                 110         


Cys Leu Leu Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu 
        115                 120                 125             


Ala Leu Glu Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu 
    130                 135                 140                 


Lys Gly Ile Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu 
145                 150                 155                 160 


Thr Ser Asp Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn 
                165                 170                 175     


Leu Ser Glu Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu 
            180                 185                 190         


Tyr Ser Pro Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro 
        195                 200                 205             


Ala Met Lys Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly 
    210                 215                 220                 


Lys Thr Phe Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe 
225                 230                 235                 240 


Pro Gln Gly Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro 
                245                 250                 255     


Val Tyr Glu Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His 
            260                 265                 270         


Gly Tyr Arg Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro 
        275                 280                 285             


Val Glu Gln Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln 
    290                 295                 300                 


Ile Leu Val Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile 
305                 310                 315                 320 


Phe Thr Leu Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His 
                325                 330                 335     


Pro Tyr Asn Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly 
            340                 345                 350         


Ser Ser Gly Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly 
        355                 360                 365             


Val Gly Asp Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys 
    370                 375                 380                 


Leu Cys Ala Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn 
385                 390                 395                 400 


Leu Glu Glu Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg 
                405                 410                 415     


Lys Val Glu Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln 
            420                 425                 430         


Leu Met Arg Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu 
        435                 440                 445             


Glu Asn Leu Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr 
    450                 455                 460                 


Glu Gln Trp Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met 
465                 470                 475                 480 


Pro Asp Lys Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr 
                485                 490                 495     


Thr Ser His Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His 
            500                 505                 510         


Ala Arg Met Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn 
        515                 520                 525             


Val Arg Ala Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg 
    530                 535                 540                 


Phe Glu Glu Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser 
545                 550                 555                 560 


Asn Glu Asn Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu 
                565                 570                 575     


Tyr His Leu Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg 
            580                 585                 590         


Ala Leu Val Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu 
        595                 600                 605             


Ser Phe Leu Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln 
    610                 615                 620                 


Asn Thr Gly Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe 
625                 630                 635                 640 


Lys Ala Ser Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp 
                645                 650                 655     


Glu Gly Ile Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr 
            660                 665                 670         


Val Gly Asn Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala 
        675                 680                 685             


Arg Gly Ser Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu 
    690                 695                 700                 


Lys Glu Gln Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile 
705                 710                 715                 720 


Leu Arg Leu Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu 
                725                 730                 735     


His Ile Gln Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro 
            740                 745                 750         


Lys Pro Val Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys 
        755                 760                 765             


Lys Ala Leu Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys 
    770                 775                 780                 


His Tyr Thr Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg 
785                 790                 795                 800 


Pro His Pro Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys 
                805                 810                 815     


Ile Phe Cys Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val 
            820                 825                 830         


Lys Tyr Lys Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val 
        835                 840                 845             


Val Glu Asp Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys 
    850                 855                 860                 


Asp Phe His Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
865                 870                 875                 880 


<210> 6611
<211> 925
<212> PRT
<213> Homo sapiens

<400> 6611
Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys 
                245                 250                 255     


Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe 
            260                 265                 270         


Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly 
        275                 280                 285             


Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu 
    290                 295                 300                 


Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg 
305                 310                 315                 320 


Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln 
                325                 330                 335     


Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val 
            340                 345                 350         


Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu 
        355                 360                 365             


Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn 
    370                 375                 380                 


Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp 
                405                 410                 415     


Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala 
            420                 425                 430         


Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu 
        435                 440                 445             


Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu 
    450                 455                 460                 


Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg 
465                 470                 475                 480 


Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu 
                485                 490                 495     


Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp 
            500                 505                 510         


Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys 
        515                 520                 525             


Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His 
    530                 535                 540                 


Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met 
545                 550                 555                 560 


Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala 
                565                 570                 575     


Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu 
            580                 585                 590         


Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn 
        595                 600                 605             


Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu 
    610                 615                 620                 


Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val 
625                 630                 635                 640 


Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu 
                645                 650                 655     


Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly 
            660                 665                 670         


Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser 
        675                 680                 685             


Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile 
    690                 695                 700                 


Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn 
705                 710                 715                 720 


Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser 
                725                 730                 735     


Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln 
            740                 745                 750         


Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu 
        755                 760                 765             


Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln 
    770                 775                 780                 


Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val 
785                 790                 795                 800 


Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu 
                805                 810                 815     


Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr 
            820                 825                 830         


Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro 
        835                 840                 845             


Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys 
    850                 855                 860                 


Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys 
865                 870                 875                 880 


Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp 
                885                 890                 895     


Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His 
            900                 905                 910         


Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
        915                 920                 925 


<210> 6612
<211> 328
<212> PRT
<213> Homo sapiens

<400> 6612
Met Asp Gly Glu Asp Ile Pro Asp Phe Ser Ser Leu Lys Glu Glu Thr 
1               5                   10                  15      


Ala Tyr Trp Lys Glu Leu Ser Leu Lys Tyr Lys Gln Ser Phe Gln Glu 
            20                  25                  30          


Ala Arg Asp Glu Leu Val Glu Phe Gln Glu Gly Ser Arg Glu Leu Glu 
        35                  40                  45              


Ala Glu Leu Glu Ala Gln Leu Val Gln Ala Glu Gln Arg Asn Arg Asp 
    50                  55                  60                  


Leu Gln Ala Asp Asn Gln Arg Leu Lys Tyr Glu Val Glu Ala Leu Lys 
65                  70                  75                  80  


Glu Lys Leu Glu His Gln Tyr Ala Gln Ser Tyr Lys Gln Val Ser Val 
                85                  90                  95      


Leu Glu Asp Asp Leu Ser Gln Thr Arg Ala Ile Lys Glu Gln Leu His 
            100                 105                 110         


Lys Tyr Val Arg Glu Leu Glu Gln Ala Asn Asp Asp Leu Glu Arg Ala 
        115                 120                 125             


Lys Arg Ala Thr Ile Val Ser Leu Glu Asp Phe Glu Gln Arg Leu Asn 
    130                 135                 140                 


Gln Ala Ile Glu Arg Asn Ala Phe Leu Glu Ser Glu Leu Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Leu Leu Val Ser Val Gln Arg Leu Lys Asp Glu Ala Arg Asp 
                165                 170                 175     


Leu Arg Gln Glu Leu Ala Val Arg Glu Arg Gln Gln Glu Val Thr Arg 
            180                 185                 190         


Lys Ser Ala Pro Ser Ser Pro Thr Leu Asp Cys Glu Lys Met Asp Ser 
        195                 200                 205             


Ala Val Gln Ala Ser Leu Ser Leu Pro Ala Thr Pro Val Gly Lys Gly 
    210                 215                 220                 


Thr Glu Asn Thr Phe Pro Ser Pro Lys Ala Ile Pro Asn Gly Phe Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Thr Pro Ser Ala Arg Ile Ser Ala Leu Asn Ile Val 
                245                 250                 255     


Gly Asp Leu Leu Arg Lys Val Gly Ala Leu Glu Ser Lys Leu Ala Ala 
            260                 265                 270         


Cys Arg Asn Phe Ala Lys Asp Gln Ala Ser Arg Lys Ser Tyr Ile Ser 
        275                 280                 285             


Gly Asn Val Asn Cys Gly Val Leu Asn Gly Asn Gly Thr Lys Phe Ser 
    290                 295                 300                 


Arg Ser Gly His Thr Ser Phe Phe Asp Lys Gly Gln Glu Lys Val Ile 
305                 310                 315                 320 


Phe Pro Thr Leu Phe Met Gly Gln 
                325             


<210> 6613
<211> 965
<212> PRT
<213> Homo sapiens

<400> 6613
Met Ala Leu Leu Cys Gly Leu Gly Gln Val Thr Leu Arg Ile Trp Val 
1               5                   10                  15      


Ser Leu Pro Ser Gln Ser Glu Asn Gly Ile Gly Phe Leu Ala Ala Arg 
            20                  25                  30          


Ala Phe Leu Arg Ser Gly Gly Met Glu Ala Leu Thr Thr Gln Leu Gly 
        35                  40                  45              


Pro Gly Arg Glu Gly Ser Ser Ser Pro Asn Ser Lys Gln Glu Leu Gln 
    50                  55                  60                  


Pro Tyr Ser Gly Ser Ser Ala Leu Lys Pro Asn Gln Val Gly Glu Thr 
65                  70                  75                  80  


Ser Leu Tyr Gly Val Pro Ile Val Ser Leu Val Ile Asp Gly Gln Glu 
                85                  90                  95      


Arg Leu Cys Leu Ala Gln Ile Ser Asn Thr Leu Leu Lys Asn Tyr Ser 
            100                 105                 110         


Tyr Asn Glu Ile His Asn Arg Arg Val Ala Leu Gly Ile Thr Cys Val 
        115                 120                 125             


Gln Cys Thr Pro Val Gln Leu Glu Ile Leu Arg Arg Ala Gly Ala Met 
    130                 135                 140                 


Pro Ile Ser Ser Arg Arg Cys Gly Met Ile Thr Lys Arg Glu Ala Glu 
145                 150                 155                 160 


Arg Leu Cys Lys Ser Phe Leu Gly Glu His Lys Pro Pro Lys Leu Pro 
                165                 170                 175     


Glu Asn Phe Ala Phe Asp Val Val His Glu Cys Ala Trp Gly Ser Arg 
            180                 185                 190         


Gly Ser Phe Ile Pro Ala Arg Tyr Asn Ser Ser Arg Ala Lys Cys Ile 
        195                 200                 205             


Lys Cys Gly Tyr Cys Ser Met Tyr Phe Ser Pro Asn Lys Phe Ile Phe 
    210                 215                 220                 


His Ser His Arg Thr Pro Asp Ala Lys Tyr Thr Gln Pro Asp Ala Ala 
225                 230                 235                 240 


Asn Phe Asn Ser Trp Arg Arg His Leu Lys Leu Ser Asp Lys Ser Ala 
                245                 250                 255     


Thr Asp Glu Leu Ser His Ala Trp Glu Asp Val Lys Ala Met Phe Asn 
            260                 265                 270         


Gly Gly Thr Arg Lys Arg Thr Phe Ser Leu Gln Gly Gly Gly Gly Gly 
        275                 280                 285             


Gly Ala Asn Gly Gly Ser Gly Gly Gln Gly Lys Gly Gly Ala Gly Gly 
    290                 295                 300                 


Gly Gly Gly Gly Gly Pro Gly Cys Gly Ala Glu Met Ala Pro Gly Pro 
305                 310                 315                 320 


Pro Pro His Lys Ser Leu Arg Cys Gly Glu Asp Glu Ala Ala Gly Pro 
                325                 330                 335     


Pro Gly Pro Pro Pro Pro His Pro Gln Arg Gly Leu Gly Leu Ala Thr 
            340                 345                 350         


Gly Ala Ser Gly Pro Ala Gly Pro Gly Gly Pro Gly Gly Gly Ala Gly 
        355                 360                 365             


Val Arg Ser Tyr Pro Val Ile Pro Val Pro Ser Lys Gly Phe Gly Leu 
    370                 375                 380                 


Leu Gln Lys Leu Pro Pro Pro Leu Phe Pro His Pro Tyr Gly Phe Pro 
385                 390                 395                 400 


Thr Ala Phe Gly Leu Cys Pro Lys Lys Asp Asp Pro Val Leu Gly Ala 
                405                 410                 415     


Gly Glu Pro Lys Gly Gly Pro Gly Thr Gly Ser Gly Gly Gly Gly Ala 
            420                 425                 430         


Gly Thr Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser His Leu Pro Pro 
        435                 440                 445             


Gly Ala Gly Ala Gly Pro Gly Gly Gly Ala Met Phe Trp Gly His Gln 
    450                 455                 460                 


Pro Ser Gly Ala Ala Lys Asp Ala Ala Ala Val Ala Ala Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Thr Val Tyr Pro Thr Phe Pro Met Phe Trp Pro Ala Ala Gly 
                485                 490                 495     


Ser Leu Pro Val Pro Ser Tyr Pro Ala Ala Gln Ser Gln Ala Lys Ala 
            500                 505                 510         


Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        515                 520                 525             


Gly Ser Gly Ala Pro Glu Pro Leu Asp Gly Ala Glu Pro Ala Lys Glu 
    530                 535                 540                 


Ser Gly Leu Gly Ala Glu Glu Arg Cys Pro Ser Ala Leu Ser Arg Gly 
545                 550                 555                 560 


Pro Leu Asp Glu Asp Gly Thr Asp Glu Ala Leu Pro Pro Pro Leu Ala 
                565                 570                 575     


Pro Leu Pro Pro Pro Pro Pro Pro Pro Ala Arg Lys Gly Ser Tyr Val 
            580                 585                 590         


Ser Ala Phe Arg Pro Val Val Lys Asp Thr Glu Ser Ile Ala Lys Leu 
        595                 600                 605             


Tyr Gly Ser Ala Arg Glu Ala Tyr Gly Ala Gly Pro Ala Arg Gly Pro 
    610                 615                 620                 


Gly Pro Gly Ala Gly Ser Gly Gly Tyr Val Ser Pro Asp Phe Leu Ser 
625                 630                 635                 640 


Glu Gly Ser Ser Ser Tyr Asn Ser Ala Ser Pro Asp Val Asp Thr Ala 
                645                 650                 655     


Asp Glu Pro Glu Val Asp Val Glu Ser Asn Arg Phe Pro Asp Asp Glu 
            660                 665                 670         


Asp Ala Gln Glu Glu Thr Glu Pro Ser Ala Pro Ser Ala Gly Gly Gly 
        675                 680                 685             


Pro Asp Gly Glu Gln Pro Thr Gly Pro Pro Ser Ala Thr Ser Ser Gly 
    690                 695                 700                 


Ala Asp Gly Pro Ala Asn Ser Pro Asp Gly Gly Ser Pro Arg Pro Arg 
705                 710                 715                 720 


Arg Arg Leu Gly Pro Pro Pro Ala Gly Arg Pro Ala Phe Gly Asp Leu 
                725                 730                 735     


Ala Ala Glu Asp Leu Val Arg Arg Pro Glu Arg Ser Pro Pro Ser Gly 
            740                 745                 750         


Gly Gly Gly Tyr Glu Leu Arg Glu Pro Cys Gly Pro Leu Gly Gly Pro 
        755                 760                 765             


Ala Pro Ala Lys Val Phe Ala Pro Glu Arg Asp Glu His Val Lys Ser 
    770                 775                 780                 


Ala Ala Val Ala Leu Gly Pro Ala Ala Ser Tyr Val Cys Thr Pro Glu 
785                 790                 795                 800 


Ala His Glu Pro Asp Lys Glu Asp Asn His Ser Pro Ala Asp Asp Leu 
                805                 810                 815     


Glu Thr Arg Lys Ser Tyr Pro Asp Gln Arg Ser Ile Ser Gln Pro Ser 
            820                 825                 830         


Pro Ala Asn Thr Asp Arg Gly Glu Asp Gly Leu Thr Leu Asp Val Thr 
        835                 840                 845             


Gly Thr His Leu Val Glu Lys Asp Ile Glu Asn Leu Ala Arg Glu Glu 
    850                 855                 860                 


Leu Gln Lys Leu Leu Leu Glu Gln Met Glu Leu Arg Lys Lys Leu Glu 
865                 870                 875                 880 


Arg Glu Phe Gln Ser Leu Lys Asp Asn Phe Gln Asp Gln Met Lys Arg 
                885                 890                 895     


Glu Leu Ala Tyr Arg Glu Glu Met Val Gln Gln Leu Gln Ile Val Arg 
            900                 905                 910         


Asp Thr Leu Cys Asn Glu Leu Asp Gln Glu Arg Lys Ala Arg Tyr Ala 
        915                 920                 925             


Ile Gln Gln Lys Leu Lys Glu Ala His Asp Ala Leu His His Phe Ser 
    930                 935                 940                 


Cys Lys Met Leu Thr Pro Arg His Cys Thr Gly Asn Cys Ser Phe Lys 
945                 950                 955                 960 


Pro Pro Leu Leu Pro 
                965 


<210> 6614
<211> 600
<212> PRT
<213> Homo sapiens

<400> 6614
Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser Val 
        115                 120                 125             


Tyr Leu Ser Tyr Glu Lys Arg Ala Glu Thr Leu Ala Val Glu Ile Lys 
    130                 135                 140                 


Glu Leu Gln Gly Gln Leu Ala Asp Tyr Asn Met Leu Val Asp Lys Leu 
145                 150                 155                 160 


Asn Thr Asn Thr Glu Met Glu Glu Val Met Asn Asp Tyr Asn Met Leu 
                165                 170                 175     


Lys Ala Gln Asn Asp Arg Glu Thr Gln Ser Leu Asp Val Ile Phe Thr 
            180                 185                 190         


Glu Arg Gln Ala Lys Glu Lys Gln Ile Arg Ser Val Glu Glu Glu Ile 
        195                 200                 205             


Glu Gln Glu Lys Gln Ala Thr Asp Asp Ile Ile Lys Asn Met Ser Phe 
    210                 215                 220                 


Glu Asn Gln Val Lys Tyr Leu Glu Met Lys Thr Thr Asn Glu Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Asp Thr Leu Gln Gln Gln Leu Asp Ser Gln Asn Met 
                245                 250                 255     


Lys Lys Glu Ser Leu Glu Ala Glu Ile Ala His Ser Gln Val Lys Gln 
            260                 265                 270         


Glu Ala Val Leu Leu His Glu Lys Leu Tyr Glu Leu Glu Ser His Arg 
        275                 280                 285             


Asp Gln Met Ile Ala Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala 
305                 310                 315                 320 


Ser Met Glu Arg Gln Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe 
                325                 330                 335     


Ile Glu Glu Ile Arg Gln Leu Asp Met Asp Leu Glu Glu His Gln Gly 
            340                 345                 350         


Glu Met Asn Gln Lys Tyr Lys Glu Leu Lys Lys Arg Glu Glu His Met 
        355                 360                 365             


Asp Thr Phe Ile Glu Thr Phe Glu Glu Thr Lys Asn Gln Glu Leu Lys 
    370                 375                 380                 


Arg Lys Ala Gln Ile Glu Ala Asn Ile Val Ala Leu Leu Glu His Cys 
385                 390                 395                 400 


Ser Arg Asn Ile Asn Arg Ile Glu Gln Ile Ser Ser Ile Thr Asn Gln 
                405                 410                 415     


Glu Leu Lys Met Met Gln Asp Asp Leu Asn Phe Lys Ser Thr Glu Val 
            420                 425                 430         


Gln Lys Ser Gln Ser Thr Ala Gln Asn Leu Thr Ser Asp Ile Gln Arg 
        435                 440                 445             


Leu Gln Leu Asp Leu Gln Lys Met Glu Leu Leu Glu Ser Lys Met Thr 
    450                 455                 460                 


Glu Glu Gln His Ser Leu Lys Ser Lys Ile Lys Gln Met Thr Thr Asp 
465                 470                 475                 480 


Leu Glu Ile Tyr Asn Asp Leu Pro Ala Leu Lys Ser Ser Gly Glu Glu 
                485                 490                 495     


Lys Ile Lys Lys Leu His Gln Glu Arg Met Ile Leu Ser Thr His Arg 
            500                 505                 510         


Asn Ala Phe Lys Lys Ile Met Glu Lys Gln Asn Ile Glu Tyr Glu Ala 
        515                 520                 525             


Leu Lys Thr Gln Leu Gln Glu Asn Glu Thr His Ser Gln Leu Thr Asn 
    530                 535                 540                 


Leu Glu Arg Lys Trp Gln His Leu Glu Gln Asn Asn Phe Ala Met Lys 
545                 550                 555                 560 


Glu Phe Ile Ala Thr Lys Ser Gln Glu Ser Asp Tyr Gln Pro Ile Lys 
                565                 570                 575     


Lys Asn Val Thr Lys Gln Ile Ala Glu Tyr Asn Lys Thr Ile Val Asp 
            580                 585                 590         


Ala Leu His Ser Thr Ser Gly Asn 
        595                 600 


<210> 6615
<211> 193
<212> PRT
<213> Homo sapiens

<400> 6615
Met Leu Val Ala Gly Asn Asp Arg Val Gln Ala Val Ile Thr Gln Met 
1               5                   10                  15      


Glu Glu Val Cys Gln Thr Ile Glu Asp Asn Ser Arg Arg Gln Lys Gln 
            20                  25                  30          


Leu Leu Asn Gln Arg Phe Glu Ser Leu Cys Ala Val Leu Glu Glu Arg 
        35                  40                  45              


Lys Gly Glu Leu Leu Gln Ala Leu Ala Arg Glu Gln Glu Glu Lys Leu 
    50                  55                  60                  


Gln Arg Val Arg Gly Leu Ile Arg Gln Tyr Gly Asp His Leu Glu Ala 
65                  70                  75                  80  


Ser Ser Lys Leu Val Glu Ser Ala Ile Gln Ser Met Glu Glu Pro Gln 
                85                  90                  95      


Met Ala Leu Tyr Leu Gln Gln Ala Lys Glu Leu Ile Asn Lys Val Gly 
            100                 105                 110         


Ala Met Ser Lys Val Glu Leu Ala Gly Arg Pro Glu Pro Gly Tyr Glu 
        115                 120                 125             


Ser Met Glu Gln Phe Thr Val Arg Val Glu His Val Ala Glu Met Leu 
    130                 135                 140                 


Arg Thr Ile Asp Phe Gln Pro Gly Ala Ser Gly Glu Glu Glu Glu Val 
145                 150                 155                 160 


Ala Pro Asp Gly Glu Glu Gly Ser Ala Gly Pro Glu Glu Glu Arg Pro 
                165                 170                 175     


Asp Gly Pro Leu Gly Pro Tyr Ser Ala Tyr Val Ser Leu Cys Gly Ala 
            180                 185                 190         


Pro 
    


<210> 6616
<211> 358
<212> PRT
<213> Homo sapiens

<400> 6616
Met Asn Phe Thr Val Gly Phe Lys Pro Leu Leu Gly Asp Ala His Ser 
1               5                   10                  15      


Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 
            20                  25                  30          


Phe Ser Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 
        35                  40                  45              


Lys Cys Ala Asn Asp Val Phe Gln Ala Ser Asn Pro Leu Trp Gln Ser 
    50                  55                  60                  


Arg Gly Ser Thr Thr Val Ser Ser Gly Gly Arg Phe Arg Cys Pro Ser 
65                  70                  75                  80  


Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 
                85                  90                  95      


Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 
            100                 105                 110         


Ser Arg Pro Leu His Ser Lys Ala Glu Gln His Leu Met Cys Glu Glu 
        115                 120                 125             


His Glu Glu Glu Lys Ile Asn Ile Tyr Cys Leu Ser Cys Glu Val Pro 
    130                 135                 140                 


Thr Cys Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Glu Val 
145                 150                 155                 160 


Ala Pro Leu Pro Thr Ile Tyr Lys Arg Gln Lys Ser Glu Leu Ser Asp 
                165                 170                 175     


Gly Ile Ala Met Leu Val Ala Gly Asn Asp Arg Val Gln Ala Val Ile 
            180                 185                 190         


Thr Gln Met Glu Glu Val Cys Gln Thr Ile Glu Asp Asn Ser Arg Arg 
        195                 200                 205             


Gln Lys Gln Leu Leu Asn Gln Arg Phe Glu Ser Leu Cys Ala Val Leu 
    210                 215                 220                 


Glu Glu Arg Lys Gly Glu Leu Leu Gln Ala Leu Ala Arg Glu Gln Glu 
225                 230                 235                 240 


Glu Lys Leu Gln Arg Val Arg Gly Leu Ile Arg Gln Tyr Gly Asp His 
                245                 250                 255     


Leu Glu Ala Ser Ser Lys Leu Val Glu Ser Ala Ile Gln Ser Met Glu 
            260                 265                 270         


Glu Pro Gln Met Ala Leu Tyr Leu Gln Gln Ala Lys Glu Leu Ile Asn 
        275                 280                 285             


Lys Val Gly Ala Met Ser Lys Val Glu Leu Ala Gly Arg Pro Glu Pro 
    290                 295                 300                 


Gly Tyr Glu Ser Met Glu Gln Phe Thr Val Arg Val Glu His Val Ala 
305                 310                 315                 320 


Glu Met Leu Arg Thr Ile Asp Phe Gln Pro Gly Ala Ser Gly Glu Glu 
                325                 330                 335     


Glu Glu Val Ala Pro Asp Gly Glu Glu Gly Ser Ala Gly Pro Glu Glu 
            340                 345                 350         


Glu Arg Pro Asp Gly Pro 
        355             


<210> 6617
<211> 251
<212> PRT
<213> Homo sapiens

<400> 6617
Met Ala Ala Ser Thr Met Ser Ile Cys Ser Ser Ala Cys Thr Asp Ser 
1               5                   10                  15      


Trp Arg Val Val Asp Cys Pro Glu Ser Cys Cys Glu Pro Cys Cys Cys 
            20                  25                  30          


Ala Pro Ala Pro Ser Leu Thr Leu Val Cys Thr Pro Val Ser Cys Val 
        35                  40                  45              


Ser Ser Pro Cys Cys Gln Thr Ala Cys Glu Pro Ser Ala Cys Gln Ser 
    50                  55                  60                  


Gly Tyr Thr Ser Ser Cys Thr Thr Pro Cys Tyr Gln Gln Ser Ser Cys 
65                  70                  75                  80  


Gln Pro Asp Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val 
                85                  90                  95      


Pro Val Cys Cys Val Pro Val Cys Cys Val Pro Val Cys Asn Lys Pro 
            100                 105                 110         


Val Cys Phe Val Pro Thr Cys Ser Glu Ser Ser Pro Ser Cys Cys Gln 
        115                 120                 125             


Gln Ser Ser Cys Gln Pro Thr Cys Cys Thr Ser Ser Pro Cys Gln Gln 
    130                 135                 140                 


Ala Cys Cys Val Pro Val Cys Ser Lys Ser Val Cys Tyr Val Pro Val 
145                 150                 155                 160 


Cys Ser Gly Ala Ser Thr Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro 
                165                 170                 175     


Ala Cys Cys Thr Ala Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu 
            180                 185                 190         


Leu Cys His Pro Val Cys Lys Ser Thr Cys Cys Val Pro Val Pro Ser 
        195                 200                 205             


Cys Gly Ala Ser Ala Ser Ser Cys Gln Pro Ser Cys Cys Arg Thr Ala 
    210                 215                 220                 


Ser Cys Val Ser Leu Leu Cys Arg Pro Val Cys Ser Arg Pro Ala Cys 
225                 230                 235                 240 


Tyr Ser Leu Cys Ser Gly Gln Lys Ser Ser Cys 
                245                 250     


<210> 6618
<211> 375
<212> PRT
<213> Homo sapiens

<400> 6618
Met Ala Ala Ser Thr Met Ser Val Cys Ser Ser Asp Leu Ser Tyr Gly 
1               5                   10                  15      


Ser Arg Val Cys Leu Pro Gly Ser Cys Asp Ser Cys Ser Asp Ser Trp 
            20                  25                  30          


Gln Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Cys Ala 
        35                  40                  45              


Pro Ser Cys Cys Ala Pro Ala Pro Cys Leu Ser Leu Val Cys Thr Pro 
    50                  55                  60                  


Val Ser Arg Val Ser Ser Pro Cys Cys Pro Val Thr Cys Glu Pro Ser 
65                  70                  75                  80  


Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys Gln 
                85                  90                  95      


Gln Ser Ser Cys Gln Leu Ala Cys Cys Ala Ser Ser Pro Cys Gln Gln 
            100                 105                 110         


Ala Cys Cys Met Pro Val Cys Cys Lys Thr Val Cys Cys Lys Pro Val 
        115                 120                 125             


Tyr Cys Val Pro Val Cys Ser Gly Asp Ser Ser Cys Cys Gln Gln Ser 
    130                 135                 140                 


Ser Cys Gln Ser Ala Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys 
145                 150                 155                 160 


Cys Val Pro Ile Cys Cys Lys Pro Val Cys Ser Gly Ile Ser Ser Ser 
                165                 170                 175     


Cys Cys Gln Gln Ser Ser Cys Val Ser Cys Val Ser Ser Pro Cys Cys 
            180                 185                 190         


Gln Ala Val Cys Glu Pro Ser Pro Cys Gln Ser Gly Cys Ile Ser Ser 
        195                 200                 205             


Cys Thr Pro Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys 
    210                 215                 220                 


Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Cys Cys Lys 
225                 230                 235                 240 


Pro Val Cys Cys Val Pro Thr Cys Ser Asp Asp Ser Gly Ser Cys Cys 
                245                 250                 255     


Gln Pro Ala Cys Cys Thr Ser Ser Gln Ser Gln Gln Gly Cys Cys Val 
            260                 265                 270         


Pro Val Cys Cys Lys Pro Val Cys Cys Val Pro Val Cys Ser Gly Ala 
        275                 280                 285             


Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr 
    290                 295                 300                 


Thr Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro 
305                 310                 315                 320 


Val Cys Arg Pro Thr Cys Cys Val Pro Val Pro Ser Cys Cys Ala Pro 
                325                 330                 335     


Thr Ser Ser Cys Gln Ala Ser Cys Cys Arg Pro Ala Ser Cys Val Ser 
            340                 345                 350         


Leu Leu Cys Arg Pro Ala Cys Ser Arg Pro Ala Cys Cys Gly Pro Thr 
        355                 360                 365             


Ser Thr Gln Lys Ser Ser Cys 
    370                 375 


<210> 6619
<211> 528
<212> PRT
<213> Homo sapiens

<400> 6619
Met Ala Thr Arg Val Glu Glu Ala Ala Arg Gly Arg Gly Gly Gly Ala 
1               5                   10                  15      


Glu Glu Ala Thr Glu Ala Gly Arg Gly Gly Arg Arg Arg Ser Pro Arg 
            20                  25                  30          


Gln Lys Phe Glu Ile Gly Thr Met Glu Glu Ala Gly Ile Cys Gly Leu 
        35                  40                  45              


Gly Val Lys Ala Asp Met Leu Cys Asn Ser Gln Ser Asn Asp Ile Leu 
    50                  55                  60                  


Gln His Gln Gly Ser Asn Cys Gly Gly Thr Ser Asn Lys His Ser Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Gly Ser Asp Phe Ile Thr Glu Asn Arg Asn Leu Val 
                85                  90                  95      


Ser Pro Ala Tyr Cys Thr Gln Glu Ser Arg Glu Glu Ile Pro Gly Gly 
            100                 105                 110         


Glu Ala Arg Thr Asp Pro Pro Asp Gly Gln Gln Asp Ser Glu Cys Asn 
        115                 120                 125             


Arg Asn Lys Glu Lys Thr Leu Gly Lys Glu Val Leu Leu Leu Met Gln 
    130                 135                 140                 


Ala Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu Cys 
145                 150                 155                 160 


Lys Lys Tyr Ala Asp Leu Leu Glu Glu Ser Arg Ser Val Gln Lys Gln 
                165                 170                 175     


Met Lys Ile Leu Gln Lys Lys Gln Ala Gln Ile Val Lys Glu Lys Val 
            180                 185                 190         


His Leu Gln Ser Glu His Ser Lys Ala Ile Leu Ala Arg Ser Lys Leu 
        195                 200                 205             


Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Lys Thr Leu Lys Glu 
    210                 215                 220                 


Glu Asn Met Gln Gln Ala Arg Glu Glu Glu Glu Arg Arg Lys Glu Ala 
225                 230                 235                 240 


Thr Ala His Phe Gln Ile Thr Leu Asn Glu Ile Gln Ala Gln Leu Glu 
                245                 250                 255     


Gln His Asp Ile His Asn Ala Lys Leu Arg Gln Glu Asn Ile Glu Leu 
            260                 265                 270         


Gly Glu Lys Leu Lys Lys Leu Ile Glu Gln Tyr Ala Leu Arg Glu Glu 
        275                 280                 285             


His Ile Asp Lys Val Phe Lys His Lys Glu Leu Gln Gln Gln Leu Val 
    290                 295                 300                 


Asp Ala Lys Leu Gln Gln Thr Thr Gln Leu Ile Lys Glu Ala Asp Glu 
305                 310                 315                 320 


Lys His Gln Arg Glu Arg Glu Phe Leu Leu Lys Glu Ala Thr Glu Ser 
                325                 330                 335     


Arg His Lys Tyr Glu Gln Met Lys Gln Gln Glu Val Gln Leu Lys Gln 
            340                 345                 350         


Gln Leu Ser Leu Tyr Met Asp Lys Phe Glu Glu Phe Gln Thr Thr Met 
        355                 360                 365             


Ala Lys Ser Asn Glu Leu Phe Thr Thr Phe Arg Gln Glu Met Glu Lys 
    370                 375                 380                 


Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Ile Ile Trp Arg 
385                 390                 395                 400 


Thr Lys Trp Glu Asn Asn Asn Lys Ala Leu Leu Gln Met Ala Glu Glu 
                405                 410                 415     


Lys Thr Val Arg Asp Lys Glu Tyr Lys Ala Leu Gln Ile Lys Leu Glu 
            420                 425                 430         


Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Glu Leu 
        435                 440                 445             


Asn Glu Lys Val Glu Val Leu Lys Glu Gln Val Ser Ile Lys Ala Ala 
    450                 455                 460                 


Ile Lys Ala Ala Asn Arg Asp Leu Ala Thr Pro Val Met Gln Pro Cys 
465                 470                 475                 480 


Thr Ala Leu Asp Ser His Lys Glu Leu Asn Thr Ser Ser Lys Arg Ala 
                485                 490                 495     


Leu Gly Ala His Leu Glu Ala Glu Pro Lys Ser Gln Arg Ser Ala Val 
            500                 505                 510         


Gln Lys Pro Pro Ser Thr Gly Ser Ala Pro Ala Ile Glu Ser Val Asp 
        515                 520                 525             


<210> 6620
<211> 132
<212> PRT
<213> Homo sapiens

<400> 6620
Met Arg Ala Ser Pro Cys Ile Ser Gln Pro Ala Ala Ser Trp His Pro 
1               5                   10                  15      


Arg Pro Ser Ala Leu Arg Pro Thr Ala Gly Ser Gly Pro Asp Thr Arg 
            20                  25                  30          


Thr Pro Gly Thr Val Glu Asp Gly Ser Ala Pro Cys Pro Ala Phe Arg 
        35                  40                  45              


Ser Pro Ala Val Ser Pro Cys Gly Glu Glu Pro Cys Cys Phe Gln Ile 
    50                  55                  60                  


Ser Pro Ala Glu Glu Thr Leu Glu Leu Gly Arg Leu Val Ser Pro Gly 
65                  70                  75                  80  


Asn Cys Asp Thr Leu Ser Pro Arg Ala Ala Gly Phe Tyr Ala Cys His 
                85                  90                  95      


Val Arg Ser Leu Ile Pro Cys Arg Ser Thr Lys Gly Arg Trp Pro Leu 
            100                 105                 110         


Thr Ala Ser Ala Ala Gly Leu Ser Arg His Ala Gln Cys Gly Pro Ser 
        115                 120                 125             


Leu Gly Leu Gly 
    130         


<210> 6621
<211> 647
<212> PRT
<213> Homo sapiens

<400> 6621
Met Ala Glu Phe Arg Val Arg Val Ser Thr Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Thr Trp Asp Lys Val Ser Val Ser Ile Val Gly Thr Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Thr Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Thr Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Thr Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Thr Leu Val Leu Gln Glu Gly Thr Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Thr Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Thr Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Thr Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Thr Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Thr Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Thr Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Thr Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Thr 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Thr Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Thr Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Thr His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Thr Leu Ala Thr Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Ser Thr Gly Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn 
                405                 410                 415     


Met Lys Gln Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg 
            420                 425                 430         


Thr Arg Gly Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly 
        435                 440                 445             


Met Gln Ile Trp Gly Ala Val Glu Arg Phe Val Ser Glu Ile Ile Gly 
    450                 455                 460                 


Ile Tyr Tyr Pro Ser Asp Glu Ser Val Gln Asp Asp Arg Glu Leu Gln 
465                 470                 475                 480 


Ala Trp Val Arg Glu Ile Phe Ser Lys Gly Phe Leu Asn Gln Glu Ser 
                485                 490                 495     


Ser Gly Ile Pro Ser Ser Leu Glu Thr Arg Glu Ala Leu Val Gln Tyr 
            500                 505                 510         


Val Thr Met Val Ile Phe Thr Cys Ser Ala Lys His Ala Ala Val Ser 
        515                 520                 525             


Ala Gly Gln Phe Asp Ser Cys Ala Trp Met Pro Asn Leu Pro Pro Ser 
    530                 535                 540                 


Met Gln Leu Pro Pro Pro Thr Ser Lys Gly Leu Ala Thr Cys Glu Gly 
545                 550                 555                 560 


Phe Ile Ala Thr Leu Pro Pro Val Asn Ala Thr Cys Asp Val Ile Leu 
                565                 570                 575     


Ala Leu Trp Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg Pro Leu Gly 
            580                 585                 590         


Thr Tyr Pro Asp Glu His Phe Thr Glu Glu Ala Pro Arg Arg Ser Ile 
        595                 600                 605             


Ala Thr Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly Ile Gln Glu 
    610                 615                 620                 


Arg Asn Gln Gly Leu Val Leu Pro Tyr Thr Tyr Leu Asp Pro Pro Leu 
625                 630                 635                 640 


Ile Glu Asn Ser Val Ser Ile 
                645         


<210> 6622
<211> 676
<212> PRT
<213> Homo sapiens

<400> 6622
Met Ala Glu Phe Arg Val Arg Val Ser Thr Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Thr Trp Asp Lys Val Ser Val Ser Ile Val Gly Thr Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Thr Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Thr Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Thr Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Thr Leu Val Leu Gln Glu Gly Thr Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Thr Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Thr Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Thr Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Thr Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Thr Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Thr Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Thr Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Thr 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Thr Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Thr Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Thr His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Thr Leu Ala Thr Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Leu Leu Ile Pro His Thr Arg Tyr Thr Leu His Ile Asn Thr Leu Ala 
                405                 410                 415     


Arg Glu Leu Leu Ile Val Pro Gly Gln Val Val Asp Arg Ser Thr Gly 
            420                 425                 430         


Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn Met Lys Gln 
        435                 440                 445             


Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg Thr Arg Gly 
    450                 455                 460                 


Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly Met Gln Ile 
465                 470                 475                 480 


Trp Gly Ala Val Glu Arg Phe Val Ser Glu Ile Ile Gly Ile Tyr Tyr 
                485                 490                 495     


Pro Ser Asp Glu Ser Val Gln Asp Asp Arg Glu Leu Gln Ala Trp Val 
            500                 505                 510         


Arg Glu Ile Phe Ser Lys Gly Phe Leu Asn Gln Glu Ser Ser Gly Ile 
        515                 520                 525             


Pro Ser Ser Leu Glu Thr Arg Glu Ala Leu Val Gln Tyr Val Thr Met 
    530                 535                 540                 


Val Ile Phe Thr Cys Ser Ala Lys His Ala Ala Val Ser Ala Gly Gln 
545                 550                 555                 560 


Phe Asp Ser Cys Ala Trp Met Pro Asn Leu Pro Pro Ser Met Gln Leu 
                565                 570                 575     


Pro Pro Pro Thr Ser Lys Gly Leu Ala Thr Cys Glu Gly Phe Ile Ala 
            580                 585                 590         


Thr Leu Pro Pro Val Asn Ala Thr Cys Asp Val Ile Leu Ala Leu Trp 
        595                 600                 605             


Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg Pro Leu Gly Thr Tyr Pro 
    610                 615                 620                 


Asp Glu His Phe Thr Glu Glu Ala Pro Arg Arg Ser Ile Ala Thr Phe 
625                 630                 635                 640 


Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly Ile Gln Glu Arg Asn Gln 
                645                 650                 655     


Gly Leu Val Leu Pro Tyr Thr Tyr Leu Asp Pro Pro Leu Ile Glu Asn 
            660                 665                 670         


Ser Val Ser Ile 
        675     


<210> 6623
<211> 554
<212> PRT
<213> Homo sapiens

<400> 6623
Met Ala Thr Ser Ala Asp Ser Pro Ser Ser Pro Leu Gly Ala Glu Asp 
1               5                   10                  15      


Leu Leu Ser Asp Ser Ser Glu Pro Pro Gly Leu Asn Gln Val Ser Ser 
            20                  25                  30          


Glu Val Thr Ser Gln Leu Tyr Ala Ser Leu Arg Leu Ser Arg Gln Ala 
        35                  40                  45              


Glu Ala Thr Ala Arg Ala Gln Leu Tyr Leu Pro Ser Thr Ser Pro Pro 
    50                  55                  60                  


His Glu Gly Leu Asp Gly Phe Ala Gln Glu Leu Ser Arg Ser Leu Ser 
65                  70                  75                  80  


Val Gly Leu Glu Lys Asn Leu Lys Lys Lys Asp Gly Ser Lys His Ile 
                85                  90                  95      


Phe Glu Met Glu Ser Val Arg Gly Gln Leu Gln Thr Met Leu Gln Thr 
            100                 105                 110         


Ser Arg Asp Thr Ala Tyr Arg Asp Pro Leu Ile Pro Gly Ala Gly Ser 
        115                 120                 125             


Glu Arg Arg Glu Glu Asp Ser Phe Asp Ser Asp Ser Thr Ala Thr Leu 
    130                 135                 140                 


Leu Asn Thr Arg Pro Leu Gln Asp Leu Ser Pro Ser Ser Ser Ala Gln 
145                 150                 155                 160 


Ala Leu Glu Glu Leu Phe Pro Arg Tyr Thr Ser Leu Arg Pro Gly Pro 
                165                 170                 175     


Pro Leu Asn Pro Pro Asp Phe Gln Gly Leu Arg Asp Ala Leu Asp Ser 
            180                 185                 190         


Glu His Thr Arg Arg Lys His Cys Glu Arg His Ile Gln Ser Leu Gln 
        195                 200                 205             


Thr Arg Val Leu Glu Leu Gln Gln Gln Leu Ala Val Ala Val Ala Ala 
    210                 215                 220                 


Asp Arg Lys Lys Asp Thr Met Ile Glu Gln Leu Asp Lys Thr Leu Ala 
225                 230                 235                 240 


Arg Val Val Glu Gly Trp Asn Arg His Glu Ala Glu Arg Thr Glu Val 
                245                 250                 255     


Leu Arg Gly Leu Gln Glu Glu His Gln Ala Ala Glu Leu Thr Arg Ser 
            260                 265                 270         


Lys Gln Gln Glu Thr Val Thr Arg Leu Glu Gln Ser Leu Ser Glu Ala 
        275                 280                 285             


Met Glu Ala Leu Asn Arg Glu Gln Glu Ser Ala Arg Leu Gln Gln Arg 
    290                 295                 300                 


Glu Arg Glu Thr Leu Glu Glu Glu Arg Gln Ala Leu Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Ala Glu Gln Gln Arg Cys Cys Val Leu Gln Glu Glu Arg Asp Ala 
                325                 330                 335     


Ala Arg Ala Gly Gln Leu Ser Glu His Arg Glu Leu Glu Thr Leu Arg 
            340                 345                 350         


Ala Ala Leu Glu Glu Glu Arg Gln Thr Trp Ala Gln Gln Glu His Gln 
        355                 360                 365             


Leu Lys Glu His Tyr Gln Ala Leu Gln Glu Glu Ser Gln Ala Gln Leu 
    370                 375                 380                 


Glu Arg Glu Lys Glu Lys Ser Gln Arg Glu Ala Gln Ala Ala Trp Glu 
385                 390                 395                 400 


Thr Gln His Gln Leu Ala Leu Val Gln Ser Glu Val Arg Arg Leu Glu 
                405                 410                 415     


Gly Glu Leu Asp Thr Ala Arg Arg Glu Arg Asp Ala Leu Gln Leu Glu 
            420                 425                 430         


Met Ser Leu Val Gln Ala Arg Tyr Glu Ser Gln Arg Ile Gln Leu Glu 
        435                 440                 445             


Ser Glu Leu Ala Val Gln Leu Glu Gln Arg Val Thr Glu Arg Leu Ala 
    450                 455                 460                 


Gln Ala Gln Glu Ser Ser Leu Arg Gln Ala Ala Ser Leu Arg Glu His 
465                 470                 475                 480 


His Arg Lys Gln Leu Gln Asp Leu Ser Gly Gln His Gln Gln Glu Leu 
                485                 490                 495     


Ala Ser Gln Leu Ala Gln Phe Lys Val Glu Met Ala Glu Arg Glu Glu 
            500                 505                 510         


Arg Gln Gln Gln Val Ala Glu Asp Tyr Glu Leu Arg Leu Leu Leu Leu 
        515                 520                 525             


Asp Pro Pro Ala Pro Gly Leu Arg Ser Pro Arg Arg Arg Arg Gly Gly 
    530                 535                 540                 


Ser Gly Leu Cys Leu Pro Trp Pro Trp Pro 
545                 550                 


<210> 6624
<211> 925
<212> PRT
<213> Homo sapiens

<400> 6624
Met Ala Thr Ser Ala Asp Ser Pro Ser Ser Pro Leu Gly Ala Glu Asp 
1               5                   10                  15      


Leu Leu Ser Asp Ser Ser Glu Pro Pro Gly Leu Asn Gln Val Ser Ser 
            20                  25                  30          


Glu Val Thr Ser Gln Leu Tyr Ala Ser Leu Arg Leu Ser Arg Gln Ala 
        35                  40                  45              


Glu Ala Thr Ala Arg Ala Gln Leu Tyr Leu Pro Ser Thr Ser Pro Pro 
    50                  55                  60                  


His Glu Gly Leu Asp Gly Phe Ala Gln Glu Leu Ser Arg Ser Leu Ser 
65                  70                  75                  80  


Val Gly Leu Glu Lys Asn Leu Lys Lys Lys Asp Gly Ser Lys His Ile 
                85                  90                  95      


Phe Glu Met Glu Ser Val Arg Gly Gln Leu Gln Thr Met Leu Gln Thr 
            100                 105                 110         


Ser Arg Asp Thr Ala Tyr Arg Asp Pro Leu Ile Pro Gly Ala Gly Ser 
        115                 120                 125             


Glu Arg Arg Glu Glu Asp Ser Phe Asp Ser Asp Ser Thr Ala Thr Leu 
    130                 135                 140                 


Leu Asn Thr Arg Pro Leu Gln Asp Leu Ser Pro Ser Ser Ser Ala Gln 
145                 150                 155                 160 


Ala Leu Glu Glu Leu Phe Pro Arg Tyr Thr Ser Leu Arg Pro Gly Pro 
                165                 170                 175     


Pro Leu Asn Pro Pro Asp Phe Gln Gly Leu Arg Asp Ala Leu Asp Ser 
            180                 185                 190         


Glu His Thr Arg Arg Lys His Cys Glu Arg His Ile Gln Ser Leu Gln 
        195                 200                 205             


Thr Arg Val Leu Glu Leu Gln Gln Gln Leu Ala Val Ala Val Ala Ala 
    210                 215                 220                 


Asp Arg Lys Lys Asp Thr Met Ile Glu Gln Leu Asp Lys Thr Leu Ala 
225                 230                 235                 240 


Arg Val Val Glu Gly Trp Asn Arg His Glu Ala Glu Arg Thr Glu Val 
                245                 250                 255     


Leu Arg Gly Leu Gln Glu Glu His Gln Ala Ala Glu Leu Thr Arg Ser 
            260                 265                 270         


Lys Gln Gln Glu Thr Val Thr Arg Leu Glu Gln Ser Leu Ser Glu Ala 
        275                 280                 285             


Met Glu Ala Leu Asn Arg Glu Gln Glu Ser Ala Arg Leu Gln Gln Arg 
    290                 295                 300                 


Glu Arg Glu Thr Leu Glu Glu Glu Arg Gln Ala Leu Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Ala Glu Gln Gln Arg Cys Cys Val Leu Gln Glu Glu Arg Asp Ala 
                325                 330                 335     


Ala Arg Ala Gly Gln Leu Ser Glu His Arg Glu Leu Glu Thr Leu Arg 
            340                 345                 350         


Ala Ala Leu Glu Glu Glu Arg Gln Thr Trp Ala Gln Gln Glu His Gln 
        355                 360                 365             


Leu Lys Glu His Tyr Gln Ala Leu Gln Glu Glu Ser Gln Ala Gln Leu 
    370                 375                 380                 


Glu Arg Glu Lys Glu Lys Ser Gln Arg Glu Ala Gln Ala Ala Trp Glu 
385                 390                 395                 400 


Thr Gln His Gln Leu Ala Leu Val Gln Ser Glu Val Arg Arg Leu Glu 
                405                 410                 415     


Gly Glu Leu Asp Thr Ala Arg Arg Glu Arg Asp Ala Leu Gln Leu Glu 
            420                 425                 430         


Met Ser Leu Val Gln Ala Arg Tyr Glu Ser Gln Arg Ile Gln Leu Glu 
        435                 440                 445             


Ser Glu Leu Ala Val Gln Leu Glu Gln Arg Val Thr Glu Arg Leu Ala 
    450                 455                 460                 


Gln Ala Gln Glu Ser Ser Leu Arg Gln Ala Ala Ser Leu Arg Glu His 
465                 470                 475                 480 


His Arg Lys Gln Leu Gln Asp Leu Ser Gly Gln His Gln Gln Glu Leu 
                485                 490                 495     


Ala Ser Gln Leu Ala Gln Phe Lys Val Glu Met Ala Glu Arg Glu Glu 
            500                 505                 510         


Arg Gln Gln Gln Val Ala Glu Asp Tyr Glu Leu Arg Leu Ala Arg Glu 
        515                 520                 525             


Gln Ala Arg Val Cys Glu Leu Gln Ser Gly Asn Gln Gln Leu Glu Glu 
    530                 535                 540                 


Gln Arg Val Glu Leu Val Glu Arg Leu Gln Ala Met Leu Gln Ala His 
545                 550                 555                 560 


Trp Asp Glu Ala Asn Gln Leu Leu Ser Thr Thr Leu Pro Pro Pro Asn 
                565                 570                 575     


Pro Pro Ala Pro Pro Ala Gly Pro Ser Ser Pro Gly Pro Gln Glu Pro 
            580                 585                 590         


Glu Lys Glu Glu Arg Arg Val Trp Thr Met Pro Pro Met Ala Val Ala 
        595                 600                 605             


Leu Lys Pro Val Leu Gln Gln Ser Arg Glu Ala Arg Asp Glu Leu Pro 
    610                 615                 620                 


Gly Ala Pro Pro Val Leu Cys Ser Ser Ser Ser Asp Leu Ser Leu Leu 
625                 630                 635                 640 


Leu Gly Pro Ser Phe Gln Ser Gln His Ser Phe Gln Pro Leu Glu Pro 
                645                 650                 655     


Lys Pro Asp Leu Thr Ser Ser Thr Ala Gly Ala Phe Ser Ala Leu Gly 
            660                 665                 670         


Ala Phe His Pro Asp His Arg Ala Glu Arg Pro Phe Pro Glu Glu Asp 
        675                 680                 685             


Pro Gly Pro Asp Gly Glu Gly Leu Leu Lys Gln Gly Leu Pro Pro Ala 
    690                 695                 700                 


Gln Leu Glu Gly Leu Lys Asn Phe Leu His Gln Leu Leu Glu Thr Val 
705                 710                 715                 720 


Pro Gln Asn Asn Glu Asn Pro Ser Val Asp Leu Leu Pro Pro Lys Ser 
                725                 730                 735     


Gly Pro Leu Thr Val Pro Ser Trp Glu Glu Ala Pro Gln Val Pro Arg 
            740                 745                 750         


Ile Pro Pro Pro Val His Lys Thr Lys Val Pro Leu Ala Met Ala Ser 
        755                 760                 765             


Ser Leu Phe Arg Val Pro Glu Pro Pro Ser Ser His Ser Gln Gly Ser 
    770                 775                 780                 


Gly Pro Ser Ser Gly Ser Pro Glu Arg Gly Gly Asp Gly Leu Thr Phe 
785                 790                 795                 800 


Pro Arg Gln Leu Met Glu Val Ser Gln Leu Leu Arg Leu Tyr Gln Ala 
                805                 810                 815     


Arg Gly Trp Gly Ala Leu Pro Ala Glu Asp Leu Leu Leu Tyr Leu Lys 
            820                 825                 830         


Arg Leu Glu His Ser Gly Tyr Lys Pro Gly Arg Lys Glu Glu Gly Phe 
        835                 840                 845             


Ser Gly Trp Lys Leu Asp Tyr Gly Glu Trp Ser Gly Thr Asp Gly Arg 
    850                 855                 860                 


Gly Asp Asn Val Pro Arg Arg Asn Thr Asp Ser Arg Leu Gly Glu Ile 
865                 870                 875                 880 


Pro Arg Lys Glu Ile Pro Ser Gln Ala Val Pro Arg Arg Leu Ala Thr 
                885                 890                 895     


Ala Pro Lys Thr Glu Lys Pro Pro Ala Arg Lys Lys Ser Gly His Pro 
            900                 905                 910         


Ala Pro Ser Ser Met Arg Ser Arg Gly Gly Val Trp Arg 
        915                 920                 925 


<210> 6625
<211> 986
<212> PRT
<213> Homo sapiens

<400> 6625
Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Ser Tyr His Thr Leu Ala Tyr Val His 
    290                 295                 300                 


Thr Thr Gly Gln Val Val Ser Phe Gly His Gly Pro Ser Asp Thr Ser 
305                 310                 315                 320 


Lys Pro Thr His Pro Glu Ala Leu Thr Glu Asn Phe Asp Ile Ser Cys 
                325                 330                 335     


Leu Ile Ser Ala Glu Asp Phe Val Asp Val Gln Val Lys His Ile Phe 
            340                 345                 350         


Ala Gly Thr Tyr Ala Asn Phe Val Thr Thr His Gln Asp Thr Ser Ser 
        355                 360                 365             


Thr Arg Ala Pro Gly Lys Thr Leu Pro Glu Ile Ser Arg Ile Ser Gln 
    370                 375                 380                 


Ser Met Ala Glu Lys Trp Ile Ala Val Lys Arg Arg Ser Thr Glu His 
385                 390                 395                 400 


Glu Met Ala Lys Ser Glu Ile Arg Met Ile Phe Ser Ser Pro Ala Cys 
                405                 410                 415     


Leu Thr Ala Ser Phe Leu Lys Lys Arg Gly Thr Gly Glu Thr Thr Ser 
            420                 425                 430         


Ile Asp Val Asp Leu Glu Met Ala Arg Asp Thr Phe Lys Lys Leu Thr 
        435                 440                 445             


Lys Lys Glu Trp Ile Ser Ser Met Ile Thr Thr Cys Leu Glu Asp Asp 
    450                 455                 460                 


Leu Leu Arg Ala Leu Pro Cys His Ser Pro His Gln Glu Ala Leu Ser 
465                 470                 475                 480 


Val Phe Leu Leu Leu Pro Glu Cys Pro Val Met His Asp Ser Lys Asn 
                485                 490                 495     


Trp Lys Asn Leu Val Val Pro Phe Ala Lys Ala Val Cys Glu Met Ser 
            500                 505                 510         


Lys Gln Ser Leu Gln Val Leu Lys Lys Cys Trp Ala Phe Leu Gln Glu 
        515                 520                 525             


Ser Ser Leu Asn Pro Leu Ile Gln Met Leu Lys Ala Ala Ile Ile Ser 
    530                 535                 540                 


Gln Leu Leu His Gln Thr Lys Thr Glu Gln Asp His Cys Asn Val Lys 
545                 550                 555                 560 


Ala Leu Leu Gly Met Met Lys Glu Leu His Lys Val Asn Lys Ala Asn 
                565                 570                 575     


Cys Arg Leu Pro Glu Asn Thr Phe Asn Ile Asn Glu Leu Ser Asn Leu 
            580                 585                 590         


Leu Asn Phe Tyr Ile Asp Arg Gly Arg Gln Leu Phe Arg Asp Asn His 
        595                 600                 605             


Leu Met Ser Glu Lys Lys Ala Tyr Met Leu Met His Glu Thr Ile Leu 
    610                 615                 620                 


Gln Lys Lys Asp Glu Phe Pro Pro Ser Pro Arg Phe Ile Leu Arg Val 
625                 630                 635                 640 


Arg Arg Ser Arg Leu Val Lys Asp Ala Leu Arg Gln Leu Ser Gln Ala 
                645                 650                 655     


Glu Ala Thr Asp Phe Cys Lys Val Leu Val Val Glu Phe Ile Asn Glu 
            660                 665                 670         


Ile Cys Pro Glu Ser Gly Gly Val Ser Ser Glu Phe Phe His Cys Met 
        675                 680                 685             


Phe Glu Glu Met Thr Lys Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu 
    690                 695                 700                 


Met Gly Ser Cys Met Trp Phe Pro Ala Lys Pro Lys Pro Glu Lys Lys 
705                 710                 715                 720 


Arg Tyr Phe Leu Phe Gly Met Leu Cys Gly Leu Ser Leu Phe Asn Leu 
                725                 730                 735     


Asn Val Ala Asn Leu Pro Phe Pro Leu Ala Leu Tyr Lys Lys Leu Leu 
            740                 745                 750         


Asp Gln Lys Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Arg Leu 
        755                 760                 765             


Gly Lys Ser Leu Gln Glu Val Leu Asp Asp Ala Ala Asp Asp Ile Gly 
    770                 775                 780                 


Asp Ala Leu Cys Ile Arg Phe Ser Ile His Trp Asp Gln Asn Asp Val 
785                 790                 795                 800 


Asp Leu Ile Pro Asn Gly Ile Ser Ile Pro Val Asp Gln Thr Asn Lys 
                805                 810                 815     


Arg Asp Tyr Val Ser Lys Tyr Ile Asp Tyr Ile Phe Asn Val Ser Val 
            820                 825                 830         


Lys Ala Val Tyr Glu Glu Phe Gln Arg Gly Phe Tyr Arg Val Cys Glu 
        835                 840                 845             


Lys Glu Ile Leu Arg His Phe Tyr Pro Glu Glu Leu Met Thr Ala Ile 
    850                 855                 860                 


Ile Gly Asn Thr Asp Tyr Asp Trp Lys Gln Phe Glu Gln Asn Ser Lys 
865                 870                 875                 880 


Tyr Glu Gln Gly Tyr Gln Lys Ser His Pro Thr Ile Gln Leu Phe Trp 
                885                 890                 895     


Lys Ala Phe His Lys Leu Thr Leu Asp Glu Lys Lys Lys Phe Leu Phe 
            900                 905                 910         


Phe Leu Thr Gly Arg Asp Arg Leu His Ala Arg Gly Ile Gln Lys Met 
        915                 920                 925             


Glu Ile Val Phe Arg Cys Pro Glu Thr Phe Ser Glu Arg Asp His Pro 
    930                 935                 940                 


Thr Ser Ile Thr Cys His Asn Ile Leu Ser Leu Pro Lys Tyr Ser Thr 
945                 950                 955                 960 


Met Glu Arg Met Glu Glu Ala Leu Gln Val Ala Ile Asn Asn Asn Arg 
                965                 970                 975     


Gly Phe Val Ser Pro Met Leu Thr Gln Ser 
            980                 985     


<210> 6626
<211> 144
<212> PRT
<213> Homo sapiens

<400> 6626
Met Thr Thr Arg Gln Ala Thr Lys Asp Pro Leu Leu Arg Gly Val Ser 
1               5                   10                  15      


Pro Thr Pro Ser Lys Ile Pro Val Arg Ser Gln Lys Arg Thr Pro Phe 
            20                  25                  30          


Pro Thr Val Thr Ser Cys Ala Val Asp Gln Glu Asn Gln Asp Pro Arg 
        35                  40                  45              


Arg Trp Val Gln Lys Pro Pro Leu Asn Ile Gln Arg Pro Leu Val Asp 
    50                  55                  60                  


Ser Ala Gly Pro Arg Pro Lys Ala Arg His Gln Ala Glu Thr Ser Gln 
65                  70                  75                  80  


Arg Leu Val Gly Ile Ser Gln Pro Arg Asn Pro Leu Glu Glu Leu Arg 
                85                  90                  95      


Pro Ser Pro Arg Gly Gln Asn Val Gly Pro Gly Pro Pro Ala Gln Thr 
            100                 105                 110         


Val Leu Val Pro Ala Pro Gly Lys Leu Phe Ala Leu Arg Arg Ser Pro 
        115                 120                 125             


Phe Pro Pro Ala Lys Cys His Leu Ala Arg Cys His Gly Leu Tyr Leu 
    130                 135                 140                 


<210> 6627
<211> 108
<212> PRT
<213> Homo sapiens

<400> 6627
Met Ala Asp Pro Arg Val Arg Gln Ile Lys Ile Lys Thr Gly Val Val 
1               5                   10                  15      


Lys Arg Leu Val Lys Glu Lys Val Met Tyr Glu Lys Glu Ala Lys Gln 
            20                  25                  30          


Gln Glu Glu Lys Ile Glu Lys Met Arg Ala Glu Asp Gly Glu Asn Tyr 
        35                  40                  45              


Asp Ile Lys Lys Gln Ala Glu Ile Leu Gln Glu Ser Arg Met Met Ile 
    50                  55                  60                  


Pro Asp Cys Gln Arg Arg Leu Glu Ala Ala Tyr Leu Asp Leu Gln Arg 
65                  70                  75                  80  


Ile Leu Glu Asn Glu Lys Asp Leu Glu Glu Ala Glu Glu Tyr Lys Glu 
                85                  90                  95      


Ala Arg Leu Val Leu Asp Ser Val Lys Leu Glu Ala 
            100                 105             


<210> 6628
<211> 446
<212> PRT
<213> Homo sapiens

<400> 6628
Met Arg Glu Cys Leu Ser Ile His Ile Gly Gln Ala Gly Ile Gln Ile 
1               5                   10                  15      


Gly Asp Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asn Gly Val Val Leu Asp Thr Gln Gln Asp Gln Leu Glu Asn Ala Lys 
        35                  40                  45              


Met Glu His Thr Asn Ala Ser Phe Asp Thr Phe Phe Cys Glu Thr Arg 
    50                  55                  60                  


Ala Gly Lys His Val Pro Arg Ala Leu Phe Val Asp Leu Glu Pro Thr 
65                  70                  75                  80  


Val Ile Asp Gly Ile Arg Thr Gly Gln His Arg Ser Leu Phe His Pro 
                85                  90                  95      


Glu Gln Leu Leu Ser Gly Lys Glu Asp Ala Ala Asn Asn Tyr Ala Arg 
            100                 105                 110         


Gly Arg Tyr Ser Val Gly Ser Glu Val Ile Asp Leu Val Leu Glu Arg 
        115                 120                 125             


Thr Arg Lys Leu Ala Glu Gln Cys Gly Gly Leu Gln Gly Phe Leu Ile 
    130                 135                 140                 


Phe Arg Ser Phe Gly Gly Gly Thr Gly Ser Gly Phe Thr Ser Leu Leu 
145                 150                 155                 160 


Met Glu Arg Leu Thr Gly Glu Tyr Ser Arg Lys Thr Lys Leu Glu Phe 
                165                 170                 175     


Ser Val Tyr Pro Ala Pro Arg Ile Ser Thr Ala Val Val Glu Pro Tyr 
            180                 185                 190         


Asn Ser Val Leu Thr Thr His Ser Thr Thr Glu His Thr Asp Cys Thr 
        195                 200                 205             


Phe Met Val Asp Asn Glu Ala Val Tyr Asp Ile Cys His Arg Lys Leu 
    210                 215                 220                 


Gly Val Glu Cys Pro Ser His Ala Ser Ile Asn Arg Leu Val Val Gln 
225                 230                 235                 240 


Val Val Ser Ser Ile Thr Ala Ser Leu Arg Phe Glu Gly Pro Leu Asn 
                245                 250                 255     


Val Asp Leu Ile Glu Phe Gln Thr Asn Leu Val Pro Tyr Pro Arg Ile 
            260                 265                 270         


His Phe Pro Met Thr Ala Phe Ala Pro Ile Val Ser Ala Asp Lys Ala 
        275                 280                 285             


Tyr His Glu Gln Phe Ser Val Ser Asp Ile Thr Thr Ala Cys Phe Glu 
    290                 295                 300                 


Ser Ser Asn Gln Leu Val Lys Cys Asp Pro Arg Leu Gly Lys Tyr Met 
305                 310                 315                 320 


Ala Cys Cys Leu Leu Tyr Arg Gly Asp Val Val Pro Lys Glu Val Asn 
                325                 330                 335     


Ala Ala Ile Ala Ala Thr Lys Ser Arg His Ser Val Gln Phe Val Asp 
            340                 345                 350         


Trp Cys Pro Thr Gly Phe Lys Val Gly Ile Asn Asn Arg Pro Pro Thr 
        355                 360                 365             


Val Met Pro Gly Gly Asp Leu Ala Lys Val His Arg Ser Ile Cys Met 
    370                 375                 380                 


Leu Ser Asn Thr Thr Ala Ile Val Glu Ala Trp Ala Arg Leu Asp His 
385                 390                 395                 400 


Lys Phe Asp Leu Met Tyr Ala Lys Arg Ala Phe Leu His Trp Tyr Leu 
                405                 410                 415     


Arg Glu Gly Met Glu Glu Ala Glu Phe Leu Glu Ala Arg Glu Asp Leu 
            420                 425                 430         


Ala Ala Leu Glu Arg Asp Tyr Glu Glu Val Ala Gln Ser Phe 
        435                 440                 445     


<210> 6629
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6629
Met Gly Ser Ser Lys Lys Val Thr Leu Ser Val Leu Ser Arg Glu Gln 
1               5                   10                  15      


Ser Glu Gly Val Gly Ala Arg Val Arg Arg Ser Ile Gly Arg Pro Glu 
            20                  25                  30          


Leu Lys Asn Leu Asp Pro Phe Leu Leu Phe Asp Glu Phe Lys Gly Gly 
        35                  40                  45              


Arg Pro Gly Gly Phe Pro Asp His Pro His Arg Gly Phe Glu Thr Val 
    50                  55                  60                  


Ser Tyr Leu Leu Glu Gly Gly Ser Met Ala His Glu Asp Phe Cys Gly 
65                  70                  75                  80  


His Thr Gly Lys Met Asn Pro Gly Asp Leu Gln Trp Met Thr Ala Gly 
                85                  90                  95      


Arg Gly Ile Leu His Ala Glu Met Pro Cys Ser Glu Glu Pro Ala His 
            100                 105                 110         


Gly Leu Gln Leu Trp Val Asn Leu Arg Ser Ser Glu Lys Met Val Glu 
        115                 120                 125             


Pro Gln Tyr Gln Glu Leu Lys Ser Glu Glu Ile Pro Lys Pro Ser Lys 
    130                 135                 140                 


Asp Gly Val Thr Val Ala Val Ile Ser Gly Glu Ala Leu Gly Ile Lys 
145                 150                 155                 160 


Ser Lys Val Tyr Thr Arg Thr Pro Thr Leu Tyr Leu Asp Phe Lys Leu 
                165                 170                 175     


Asp Pro Gly Ala Lys His Ser Gln Pro Ile Pro Lys Gly Trp Thr Ser 
            180                 185                 190         


Phe Ile Tyr Thr Ile Ser Gly Asp Val Tyr Ile Gly Pro Asp Asp Ala 
        195                 200                 205             


Gln Gln Lys Ile Glu Pro His His Thr Ala Val Leu Gly Glu Gly Asp 
    210                 215                 220                 


Ser Val Gln Val Glu Asn Lys Asp Pro Lys Arg Ser His Phe Val Leu 
225                 230                 235                 240 


Ile Ala Gly Glu Pro Leu Arg Glu Pro Val Ile Gln His Gly Pro Phe 
                245                 250                 255     


Val Met Asn Thr Asn Glu Glu Ile Ser Gln Ala Ile Leu Asp Phe Arg 
            260                 265                 270         


Asn Ala Lys Asn Gly Phe Glu Arg Ala Lys Thr Trp Lys Ser Lys Ile 
        275                 280                 285             


Gly Asn 
    290 


<210> 6630
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6630
Met Gly Ser Ser Lys Lys Val Thr Leu Ser Val Leu Ser Arg Glu Gln 
1               5                   10                  15      


Ser Glu Gly Val Gly Ala Arg Val Arg Arg Ser Ile Gly Arg Pro Glu 
            20                  25                  30          


Leu Lys Asn Leu Asp Pro Phe Leu Leu Phe Asp Glu Phe Lys Gly Gly 
        35                  40                  45              


Arg Pro Gly Gly Phe Pro Asp His Pro His Arg Gly Phe Glu Thr Val 
    50                  55                  60                  


Ser Tyr Leu Leu Glu Gly Gly Ser Met Ala His Glu Asp Phe Cys Gly 
65                  70                  75                  80  


His Thr Gly Lys Met Asn Pro Gly Asp Leu Gln Trp Met Thr Ala Gly 
                85                  90                  95      


Arg Gly Ile Leu His Ala Glu Met Pro Cys Ser Glu Glu Pro Ala His 
            100                 105                 110         


Gly Leu Gln Leu Trp Val Asn Leu Arg Ser Ser Glu Lys Met Val Glu 
        115                 120                 125             


Pro Gln Tyr Gln Glu Leu Lys Ser Glu Glu Ile Pro Lys Pro Ser Lys 
    130                 135                 140                 


Asp Gly Val Thr Val Ala Val Ile Ser Gly Glu Ala Leu Gly Ile Lys 
145                 150                 155                 160 


Ser Lys Val Tyr Thr Arg Thr Pro Thr Leu Tyr Leu Asp Phe Lys Leu 
                165                 170                 175     


Asp Pro Gly Ala Lys His Ser Gln Pro Ile Pro Lys Gly Trp Thr Ser 
            180                 185                 190         


Phe Ile Tyr Thr Ile Ser Gly Asp Val Tyr Ile Gly Pro Asp Asp Ala 
        195                 200                 205             


Gln Gln Lys Ile Glu Pro His His Thr Ala Val Leu Gly Glu Gly Asp 
    210                 215                 220                 


Ser Val Gln Val Glu Asn Lys Asp Pro Lys Arg Ser His Phe Val Leu 
225                 230                 235                 240 


Ile Ala Gly Glu Pro Leu Arg Glu Pro Val Ile Gln His Gly Pro Phe 
                245                 250                 255     


Val Met Asn Thr Asn Glu Glu Ile Ser Gln Ala Ile Leu Asp Phe Arg 
            260                 265                 270         


Asn Ala Lys Asn Gly Phe Glu Arg Ala Lys Thr Trp Lys Ser Lys Ile 
        275                 280                 285             


Gly Asn 
    290 


<210> 6631
<211> 399
<212> PRT
<213> Homo sapiens

<400> 6631
Met Asp Phe Phe Ser Ser His Leu Leu Ala Asp Ser Ser Ser Pro Ala 
1               5                   10                  15      


Thr Asn Ser Ser His Thr Asp Ala His Glu Ile Leu Val Ser Asp Phe 
            20                  25                  30          


Leu Val Ser Asp Glu Asn Leu Gln Lys Met Glu Asn Val Leu Asp Leu 
        35                  40                  45              


Trp Ser Ser Gly Leu Lys Thr Asn Ile Ile Ser Glu Leu Ser Lys Trp 
    50                  55                  60                  


Arg Leu Asn Phe Ile Asp Trp His Arg Met Glu Met Arg Lys Glu Lys 
65                  70                  75                  80  


Glu Lys His Ala Ala His Leu Lys Gln Leu Cys Asn Gln Ile Asn Glu 
                85                  90                  95      


Leu Lys Glu Leu Gln Lys Thr Phe Glu Ile Ser Ile Gly Arg Lys Asp 
            100                 105                 110         


Glu Val Ile Ser Ser Leu Ser His Ala Ile Gly Lys Gln Lys Glu Lys 
        115                 120                 125             


Ile Glu Leu Met Arg Thr Phe Phe His Trp Arg Ile Gly His Val Arg 
    130                 135                 140                 


Ala Arg Gln Asp Val Tyr Glu Gly Lys Leu Ala Asp Gln Tyr Tyr Gln 
145                 150                 155                 160 


Arg Thr Leu Leu Lys Lys Val Trp Lys Val Trp Arg Ser Val Val Gln 
                165                 170                 175     


Lys Gln Trp Lys Asp Val Val Glu Arg Ala Cys Gln Ala Arg Ala Glu 
            180                 185                 190         


Glu Val Cys Ile Gln Ile Ser Asn Asp Tyr Glu Ala Lys Val Ala Met 
        195                 200                 205             


Leu Ser Gly Ala Leu Glu Asn Ala Lys Ala Glu Ile Gln Arg Met Gln 
    210                 215                 220                 


His Glu Lys Glu His Phe Glu Asp Ser Met Lys Lys Ala Phe Met Arg 
225                 230                 235                 240 


Gly Val Cys Ala Leu Asn Leu Glu Ala Met Thr Ile Phe Gln Asn Arg 
                245                 250                 255     


Asn Asp Ala Gly Ile Asp Ser Thr Asn Asn Lys Lys Glu Glu Tyr Gly 
            260                 265                 270         


Pro Gly Val Gln Gly Lys Glu His Ser Ala His Leu Asp Pro Ser Ala 
        275                 280                 285             


Pro Pro Met Pro Leu Pro Val Thr Ser Pro Leu Leu Pro Ser Pro Pro 
    290                 295                 300                 


Ala Ala Val Gly Gly Ala Ser Ala Thr Ala Val Pro Ser Ala Ala Ser 
305                 310                 315                 320 


Met Thr Ser Thr Arg Ala Ala Ser Ala Ser Ser Val His Val Pro Val 
                325                 330                 335     


Ser Ala Leu Gly Ala Gly Ser Ala Ala Thr Ala Ala Ser Glu Glu Met 
            340                 345                 350         


Gln Thr Ile Pro Gln Ala Thr Ala Ala Lys Tyr Pro Arg Thr Ile His 
        355                 360                 365             


Pro Glu Ser Ser Thr Ser Ala Ser Arg Ser Leu Gly Thr Arg Ser Ala 
    370                 375                 380                 


His Thr Gln Ser Leu Thr Ser Val His Ser Ile Lys Val Val Asp 
385                 390                 395                 


<210> 6632
<211> 242
<212> PRT
<213> Homo sapiens

<400> 6632
Met Ala Ala Val Lys Ala Ser Thr Ser Lys Ala Thr Arg Pro Trp Tyr 
1               5                   10                  15      


Ser His Pro Val Tyr Ala Arg Tyr Trp Gln His Tyr His Gln Ala Met 
            20                  25                  30          


Ala Trp Met Gln Ser His His Asn Ala Tyr Arg Lys Ala Val Glu Ser 
        35                  40                  45              


Cys Phe Asn Leu Pro Trp Tyr Leu Pro Ser Ala Leu Leu Pro Gln Ser 
    50                  55                  60                  


Ser Tyr Asp Asn Glu Ala Ala Tyr Pro Gln Ser Phe Tyr Asp His His 
65                  70                  75                  80  


Val Ala Trp Gln Asp Tyr Pro Cys Ser Ser Ser His Phe Arg Arg Ser 
                85                  90                  95      


Gly Gln His Pro Arg Tyr Ser Ser Arg Ile Gln Ala Ser Thr Lys Glu 
            100                 105                 110         


Asp Gln Ala Leu Ser Lys Glu Glu Glu Met Glu Thr Glu Ser Asp Ala 
        115                 120                 125             


Glu Val Glu Cys Asp Leu Ser Asn Met Glu Ile Thr Glu Glu Leu Arg 
    130                 135                 140                 


Gln Tyr Phe Ala Glu Thr Glu Arg His Arg Glu Glu Arg Arg Arg Gln 
145                 150                 155                 160 


Gln Gln Leu Asp Ala Glu Arg Leu Asp Ser Tyr Val Asn Ala Asp His 
                165                 170                 175     


Asp Leu Tyr Cys Asn Thr Arg Arg Ser Val Glu Ala Pro Thr Glu Arg 
            180                 185                 190         


Pro Gly Glu Arg Arg Gln Ala Glu Met Lys Arg Leu Tyr Gly Asp Ser 
        195                 200                 205             


Ala Ala Lys Ile Gln Ala Met Glu Ala Ala Val Gln Leu Ser Phe Asp 
    210                 215                 220                 


Lys His Cys Asp Arg Lys Gln Pro Lys Tyr Trp Pro Val Ile Pro Leu 
225                 230                 235                 240 


Lys Phe 
        


<210> 6633
<211> 493
<212> PRT
<213> Homo sapiens

<400> 6633
Met Glu Arg Ser Pro Asp Val Ser Pro Gly Pro Ser Arg Ser Phe Lys 
1               5                   10                  15      


Glu Glu Leu Leu Cys Ala Val Cys Tyr Asp Pro Phe Arg Asp Ala Val 
            20                  25                  30          


Thr Leu Arg Cys Gly His Asn Phe Cys Arg Gly Cys Val Ser Arg Cys 
        35                  40                  45              


Trp Glu Val Gln Val Ser Pro Thr Cys Pro Val Cys Lys Asp Arg Ala 
    50                  55                  60                  


Ser Pro Ala Asp Leu Arg Thr Asn His Thr Leu Asn Asn Leu Val Glu 
65                  70                  75                  80  


Lys Leu Leu Arg Glu Glu Ala Glu Gly Ala Arg Trp Thr Ser Tyr Arg 
                85                  90                  95      


Phe Ser Arg Val Cys Arg Leu His Arg Gly Gln Leu Ser Leu Phe Cys 
            100                 105                 110         


Leu Glu Asp Lys Glu Leu Leu Cys Cys Ser Cys Gln Ala Asp Pro Arg 
        115                 120                 125             


His Gln Gly His Arg Val Gln Pro Val Lys Asp Thr Ala His Asp Phe 
    130                 135                 140                 


Arg Val Arg Ser Leu Ile Ala Glu Glu Arg Arg Asn Phe Leu Pro Thr 
145                 150                 155                 160 


His Gln Trp Ile Val Thr Lys Thr Arg Leu Gln Thr Ser Ser Pro Asn 
                165                 170                 175     


Leu Gln Ser Arg Arg Gln Gly Gln Val Gln Glu His Gly Ala Cys Thr 
            180                 185                 190         


Ala Gly Glu Gly Gln Gly Leu Leu Gly His Ala Ala Leu Leu Asp Ala 
        195                 200                 205             


Met Ala Glu Glu Thr Arg Gln Lys Gln Leu Leu Ala Asp Glu Lys Met 
    210                 215                 220                 


Lys Gln Leu Thr Glu Glu Thr Glu Val Leu Ala His Glu Ile Glu Arg 
225                 230                 235                 240 


Leu Gln Met Glu Met Lys Glu Asp Asp Val Ser Phe Leu Met Lys His 
                245                 250                 255     


Lys Ser Arg Lys Arg Arg Leu Phe Cys Thr Met Glu Pro Glu Pro Val 
            260                 265                 270         


Gln Pro Gly Met Leu Ile Asp Val Cys Lys Tyr Leu Gly Ser Leu Gln 
        275                 280                 285             


Tyr Arg Val Trp Lys Lys Met Leu Ala Ser Val Glu Ser Val Pro Phe 
    290                 295                 300                 


Ser Phe Asp Pro Asn Thr Ala Ala Gly Trp Leu Ser Val Ser Asp Asp 
305                 310                 315                 320 


Leu Thr Ser Val Thr Asn His Gly Tyr Arg Val Gln Val Glu Asn Pro 
                325                 330                 335     


Glu Arg Phe Ser Ser Ala Pro Cys Leu Leu Gly Ser Arg Val Phe Ser 
            340                 345                 350         


Gln Gly Ser His Ala Trp Glu Val Ala Leu Gly Gly Leu Gln Ser Trp 
        355                 360                 365             


Arg Val Gly Val Val Arg Val Arg Gln Asp Ser Gly Ala Glu Gly His 
    370                 375                 380                 


Ser His Ser Cys Tyr His Asp Thr Arg Ser Gly Phe Trp Tyr Val Cys 
385                 390                 395                 400 


Arg Thr Gln Gly Val Glu Gly Asp His Cys Val Thr Ser Asp Pro Ala 
                405                 410                 415     


Thr Ser Pro Leu Val Leu Ala Ile Pro Arg Arg Leu Arg Val Glu Leu 
            420                 425                 430         


Glu Cys Glu Glu Gly Glu Leu Ser Phe Tyr Asp Ala Glu Arg His Cys 
        435                 440                 445             


His Leu Tyr Thr Phe His Ala Arg Phe Gly Glu Val Arg Pro Tyr Phe 
    450                 455                 460                 


Tyr Leu Gly Gly Ala Arg Gly Ala Gly Pro Pro Glu Pro Leu Arg Ile 
465                 470                 475                 480 


Cys Pro Leu His Ile Ser Val Lys Glu Glu Leu Asp Gly 
                485                 490             


<210> 6634
<211> 490
<212> PRT
<213> Homo sapiens

<400> 6634
Met Asn Leu Ala Glu Ile Cys Asp Asn Ala Lys Lys Gly Arg Glu Tyr 
1               5                   10                  15      


Ala Leu Leu Gly Asn Tyr Asp Ser Ser Met Val Tyr Tyr Gln Gly Val 
            20                  25                  30          


Met Gln Gln Ile Gln Arg His Cys Gln Ser Val Arg Asp Pro Ala Ile 
        35                  40                  45              


Lys Gly Lys Trp Gln Gln Val Arg Gln Glu Leu Leu Glu Glu Tyr Glu 
    50                  55                  60                  


Gln Val Lys Ser Ile Val Ser Thr Leu Glu Ser Phe Lys Ile Asp Lys 
65                  70                  75                  80  


Pro Pro Asp Phe Pro Val Ser Cys Gln Asp Glu Pro Phe Arg Asp Pro 
                85                  90                  95      


Ala Val Trp Pro Pro Pro Val Pro Ala Glu His Arg Ala Pro Pro Gln 
            100                 105                 110         


Ile Arg Arg Pro Asn Arg Glu Val Arg Pro Leu Arg Lys Glu Met Ala 
        115                 120                 125             


Gly Val Gly Ala Arg Gly Pro Val Gly Arg Ala His Pro Ile Ser Lys 
    130                 135                 140                 


Ser Glu Lys Pro Ser Thr Ser Arg Asp Lys Asp Tyr Arg Ala Arg Gly 
145                 150                 155                 160 


Arg Asp Asp Lys Gly Arg Lys Asn Met Gln Asp Gly Ala Ser Asp Gly 
                165                 170                 175     


Glu Met Pro Lys Phe Asp Gly Ala Gly Tyr Asp Lys Asp Leu Val Glu 
            180                 185                 190         


Ala Leu Glu Arg Asp Ile Val Ser Arg Asn Pro Ser Ile His Trp Asp 
        195                 200                 205             


Asp Ile Ala Asp Leu Glu Glu Ala Lys Lys Leu Leu Arg Glu Ala Val 
    210                 215                 220                 


Val Leu Pro Met Trp Met Pro Asp Phe Phe Lys Gly Ile Arg Arg Pro 
225                 230                 235                 240 


Trp Lys Gly Val Leu Met Val Gly Pro Pro Gly Thr Gly Lys Thr Met 
                245                 250                 255     


Leu Ala Lys Ala Val Ala Thr Glu Cys Gly Thr Thr Phe Phe Asn Val 
            260                 265                 270         


Ser Ser Ser Thr Leu Thr Ser Lys Tyr Arg Gly Glu Ser Glu Lys Leu 
        275                 280                 285             


Val Arg Leu Leu Phe Glu Met Ala Arg Phe Tyr Ala Pro Thr Thr Ile 
    290                 295                 300                 


Phe Ile Asp Glu Ile Asp Ser Ile Cys Ser Arg Arg Gly Thr Ser Asp 
305                 310                 315                 320 


Glu His Glu Ala Ser Arg Arg Val Lys Ser Glu Leu Leu Ile Gln Met 
                325                 330                 335     


Asp Gly Val Gly Gly Ala Leu Glu Asn Asp Asp Pro Ser Lys Met Val 
            340                 345                 350         


Met Val Leu Ala Ala Thr Asn Phe Pro Trp Asp Ile Asp Glu Ala Leu 
        355                 360                 365             


Arg Arg Arg Leu Glu Lys Arg Ile Tyr Ile Pro Leu Pro Thr Ala Lys 
    370                 375                 380                 


Gly Arg Ala Glu Leu Leu Lys Ile Asn Leu Arg Glu Val Glu Leu Asp 
385                 390                 395                 400 


Pro Asp Ile Gln Leu Glu Asp Ile Ala Glu Lys Ile Glu Gly Tyr Ser 
                405                 410                 415     


Gly Ala Asp Ile Thr Asn Val Cys Arg Asp Ala Ser Leu Met Ala Met 
            420                 425                 430         


Arg Arg Arg Ile Asn Gly Leu Ser Pro Glu Glu Ile Arg Ala Leu Ser 
        435                 440                 445             


Lys Glu Glu Leu Gln Met Pro Val Thr Lys Gly Asp Phe Glu Leu Ala 
    450                 455                 460                 


Leu Lys Lys Ile Ala Lys Ser Val Ser Ala Ala Asp Leu Glu Lys Tyr 
465                 470                 475                 480 


Glu Lys Trp Met Val Glu Phe Gly Ser Ala 
                485                 490 


<210> 6635
<211> 490
<212> PRT
<213> Homo sapiens

<400> 6635
Met Asn Leu Ala Glu Ile Cys Asp Asn Ala Lys Lys Gly Arg Glu Tyr 
1               5                   10                  15      


Ala Leu Leu Gly Asn Tyr Asp Ser Ser Met Val Tyr Tyr Gln Gly Val 
            20                  25                  30          


Met Gln Gln Ile Gln Arg His Cys Gln Ser Val Arg Asp Pro Ala Ile 
        35                  40                  45              


Lys Gly Lys Trp Gln Gln Val Arg Gln Glu Leu Leu Glu Glu Tyr Glu 
    50                  55                  60                  


Gln Val Lys Ser Ile Val Ser Thr Leu Glu Ser Phe Lys Ile Asp Lys 
65                  70                  75                  80  


Pro Pro Asp Phe Pro Val Ser Cys Gln Asp Glu Pro Phe Arg Asp Pro 
                85                  90                  95      


Ala Val Trp Pro Pro Pro Val Pro Ala Glu His Arg Ala Pro Pro Gln 
            100                 105                 110         


Ile Arg Arg Pro Asn Arg Glu Val Arg Pro Leu Arg Lys Glu Met Ala 
        115                 120                 125             


Gly Val Gly Ala Arg Gly Pro Val Gly Arg Ala His Pro Ile Ser Lys 
    130                 135                 140                 


Ser Glu Lys Pro Ser Thr Ser Arg Asp Lys Asp Tyr Arg Ala Arg Gly 
145                 150                 155                 160 


Arg Asp Asp Lys Gly Arg Lys Asn Met Gln Asp Gly Ala Ser Asp Gly 
                165                 170                 175     


Glu Met Pro Lys Phe Asp Gly Ala Gly Tyr Asp Lys Asp Leu Val Glu 
            180                 185                 190         


Ala Leu Glu Arg Asp Ile Val Ser Arg Asn Pro Ser Ile His Trp Asp 
        195                 200                 205             


Asp Ile Ala Asp Leu Glu Glu Ala Lys Lys Leu Leu Arg Glu Ala Val 
    210                 215                 220                 


Val Leu Pro Met Trp Met Pro Asp Phe Phe Lys Gly Ile Arg Arg Pro 
225                 230                 235                 240 


Trp Lys Gly Val Leu Met Val Gly Pro Pro Gly Thr Gly Lys Thr Met 
                245                 250                 255     


Leu Ala Lys Ala Val Ala Thr Glu Cys Gly Thr Thr Phe Phe Asn Val 
            260                 265                 270         


Ser Ser Ser Thr Leu Thr Ser Lys Tyr Arg Gly Glu Ser Glu Lys Leu 
        275                 280                 285             


Val Arg Leu Leu Phe Glu Met Ala Arg Phe Tyr Ala Pro Thr Thr Ile 
    290                 295                 300                 


Phe Ile Asp Glu Ile Asp Ser Ile Cys Ser Arg Arg Gly Thr Ser Asp 
305                 310                 315                 320 


Glu His Glu Ala Ser Arg Arg Val Lys Ser Glu Leu Leu Ile Gln Met 
                325                 330                 335     


Asp Gly Val Gly Gly Ala Leu Glu Asn Asp Asp Pro Ser Lys Met Val 
            340                 345                 350         


Met Val Leu Ala Ala Thr Asn Phe Pro Trp Asp Ile Asp Glu Ala Leu 
        355                 360                 365             


Arg Arg Arg Leu Glu Lys Arg Ile Tyr Ile Pro Leu Pro Thr Ala Lys 
    370                 375                 380                 


Gly Arg Ala Glu Leu Leu Lys Ile Asn Leu Arg Glu Val Glu Leu Asp 
385                 390                 395                 400 


Pro Asp Ile Gln Leu Glu Asp Ile Ala Glu Lys Ile Glu Gly Tyr Ser 
                405                 410                 415     


Gly Ala Asp Ile Thr Asn Val Cys Arg Asp Ala Ser Leu Met Ala Met 
            420                 425                 430         


Arg Arg Arg Ile Asn Gly Leu Ser Pro Glu Glu Ile Arg Ala Leu Ser 
        435                 440                 445             


Lys Glu Glu Leu Gln Met Pro Val Thr Lys Gly Asp Phe Glu Leu Ala 
    450                 455                 460                 


Leu Lys Lys Ile Ala Lys Ser Val Ser Ala Ala Asp Leu Glu Lys Tyr 
465                 470                 475                 480 


Glu Lys Trp Met Val Glu Phe Gly Ser Ala 
                485                 490 


<210> 6636
<211> 355
<212> PRT
<213> Homo sapiens

<400> 6636
Met Asp Phe Ile Phe His Glu Lys Gln Glu Gly Phe Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ala Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Glu Tyr Leu Ala Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Glu Asn Met Asp Asp Thr Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Phe Trp Gly Leu Glu Ile Ile His Phe Asn Asn 
                85                  90                  95      


Pro Glu Tyr Gln Lys Leu Gly Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Gln His Trp Phe Thr Ile Arg Lys Phe Gly Lys 
        115                 120                 125             


His Trp Phe Asn Leu Asn Ser Leu Leu Ala Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Cys Leu Ala Asn Phe Leu Ala Arg Leu Gln Gln Gln Ala Tyr 
145                 150                 155                 160 


Ser Val Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Ile Ile Ser Val Glu Glu Met Asp Thr Pro Lys Leu Asn 
            180                 185                 190         


Gly Lys Lys Leu Val Lys Gln Lys Glu His Arg Val Tyr Lys Thr Val 
        195                 200                 205             


Leu Glu Lys Val Ser Glu Glu Ser Asp Glu Ser Gly Thr Ser Asp Gln 
    210                 215                 220                 


Asp Glu Glu Asp Phe Gln Arg Ala Leu Glu Leu Ser Arg Gln Glu Thr 
225                 230                 235                 240 


Asn Arg Glu Asp Glu His Leu Arg Ser Thr Ile Glu Leu Ser Met Gln 
                245                 250                 255     


Gly Ser Ser Gly Asn Thr Ser Gln Asp Leu Pro Lys Thr Ser Cys Val 
            260                 265                 270         


Thr Pro Ala Ser Glu Gln Pro Lys Lys Ile Lys Glu Asp Tyr Phe Glu 
        275                 280                 285             


Lys His Gln Gln Glu Gln Lys Gln Gln Gln Gln Gln Ser Asp Leu Pro 
    290                 295                 300                 


Gly His Ser Ser Tyr Leu His Glu Arg Pro Thr Thr Ser Ser Arg Ala 
305                 310                 315                 320 


Ile Glu Ser Asp Leu Ser Asp Asp Ile Ser Glu Gly Thr Val Gln Ala 
                325                 330                 335     


Ala Val Asp Thr Ile Leu Glu Ile Met Arg Lys Asn Leu Lys Ile Lys 
            340                 345                 350         


Gly Glu Lys 
        355 


<210> 6637
<211> 1969
<212> PRT
<213> Homo sapiens

<400> 6637
Met Ala Ala Arg Ser Ala Pro Ser Cys His Leu Arg Leu Glu Trp Val 
1               5                   10                  15      


Tyr Gly Tyr Arg Gly His Gln Cys Arg Asn Asn Leu Tyr Tyr Thr Ala 
            20                  25                  30          


Ala Lys Glu Ile Val Tyr Phe Val Ala Gly Val Gly Val Val Tyr Ser 
        35                  40                  45              


Pro Arg Glu His Arg Gln Lys Phe Tyr Arg Gly His Ser Asp Asp Ile 
    50                  55                  60                  


Ile Ser Leu Ala Leu His Pro Glu Arg Val Leu Val Ala Thr Gly Gln 
65                  70                  75                  80  


Val Gly Lys Glu Pro Tyr Ile Cys Ile Trp Asp Ser Tyr Thr Val Gln 
                85                  90                  95      


Thr Ile Ser Val Leu Lys Asp Val His Thr His Gly Ile Ala Cys Leu 
            100                 105                 110         


Ala Phe Asp Leu Asp Gly Gln Arg Leu Val Ser Val Gly Leu Asp Ser 
        115                 120                 125             


Lys Asn Ala Val Cys Val Trp Asp Trp Lys Arg Gly Lys Met Leu Ser 
    130                 135                 140                 


Met Ala Pro Gly His Thr Asp Arg Ile Phe Asp Ile Ser Trp Asp Leu 
145                 150                 155                 160 


Tyr Gln Pro Asn Lys Leu Val Ser Cys Gly Val Lys His Ile Lys Phe 
                165                 170                 175     


Trp Ser Leu Cys Gly Asn Ala Leu Thr Pro Lys Arg Gly Val Phe Gly 
            180                 185                 190         


Lys Thr Gly Asp Leu Gln Thr Ile Leu Cys Leu Ala Cys Ala Arg Asp 
        195                 200                 205             


Glu Leu Thr Tyr Ser Gly Ala Leu Asn Gly Asp Ile Tyr Val Trp Lys 
    210                 215                 220                 


Gly Ile Asn Leu Ile Arg Thr Ile Gln Gly Ala His Ala Ala Gly Ile 
225                 230                 235                 240 


Phe Ser Met Asn Ala Cys Glu Glu Gly Phe Ala Thr Gly Gly Arg Asp 
                245                 250                 255     


Gly Cys Ile Arg Leu Trp Asp Leu Thr Phe Lys Pro Ile Thr Val Ile 
            260                 265                 270         


Asp Leu Arg Glu Thr Asp Gln Gly Tyr Lys Gly Leu Ser Val Arg Ser 
        275                 280                 285             


Val Cys Trp Arg Gly Asp His Ile Leu Val Gly Thr Gln Asp Ser Glu 
    290                 295                 300                 


Ile Phe Glu Ile Val Val Gln Glu Arg Asn Lys Pro Phe Leu Ile Met 
305                 310                 315                 320 


Gln Gly His Cys Glu Gly Glu Leu Trp Ala Leu Ala Val His Pro Thr 
                325                 330                 335     


Lys Pro Leu Ala Val Thr Gly Ser Asp Asp Arg Ser Val Arg Ile Trp 
            340                 345                 350         


Ser Leu Val Asp His Ala Leu Ile Ala Arg Cys Asn Met Glu Glu Pro 
        355                 360                 365             


Ile Arg Cys Ala Ala Val Asn Ala Asp Gly Ile His Leu Ala Leu Gly 
    370                 375                 380                 


Met Lys Asp Gly Ser Phe Thr Val Leu Arg Val Arg Asp Met Thr Glu 
385                 390                 395                 400 


Val Val His Ile Lys Asp Arg Lys Glu Ala Ile His Glu Leu Lys Tyr 
                405                 410                 415     


Ser Pro Asp Gly Thr Tyr Leu Ala Val Gly Cys Asn Asp Ser Ser Val 
            420                 425                 430         


Asp Ile Tyr Gly Val Ala Gln Arg Tyr Lys Lys Val Gly Glu Cys Leu 
        435                 440                 445             


Gly Ser Leu Ser Phe Ile Thr His Leu Asp Trp Ser Ser Asp Ser Arg 
    450                 455                 460                 


Tyr Leu Gln Thr Asn Asp Gly Asn Gly Lys Arg Leu Phe Tyr Arg Met 
465                 470                 475                 480 


Pro Gly Gly Lys Glu Val Thr Ser Thr Glu Glu Ile Lys Gly Val His 
                485                 490                 495     


Trp Ala Ser Trp Thr Cys Val Ser Gly Leu Glu Val Asn Gly Ile Trp 
            500                 505                 510         


Pro Lys Tyr Ser Asp Ile Asn Asp Ile Asn Ser Val Asp Gly Asn Tyr 
        515                 520                 525             


Ile Gly Gln Val Leu Val Thr Ala Asp Asp Tyr Gly Ile Ile Lys Leu 
    530                 535                 540                 


Phe Arg Tyr Pro Cys Leu Arg Lys Gly Ala Lys Phe Arg Lys Tyr Ile 
545                 550                 555                 560 


Gly His Ser Ala His Val Thr Asn Val Arg Trp Ser His Asp Tyr Gln 
                565                 570                 575     


Trp Val Ile Ser Ile Gly Gly Ala Asp His Ser Val Phe Gln Trp Lys 
            580                 585                 590         


Phe Ile Pro Glu Arg Lys Leu Lys Asp Ala Val His Ile Ala Pro Gln 
        595                 600                 605             


Glu Ser Leu Ala Asp Ser His Ser Asp Glu Ser Asp Ser Asp Leu Ser 
    610                 615                 620                 


Asp Val Pro Glu Leu Asp Ser Glu Ile Glu Gln Glu Thr Gln Leu Thr 
625                 630                 635                 640 


Tyr Arg Arg Gln Val Tyr Lys Glu Asp Leu Pro Gln Leu Lys Glu Gln 
                645                 650                 655     


Cys Lys Glu Lys Gln Lys Ser Ala Thr Ser Lys Arg Arg Glu Arg Ala 
            660                 665                 670         


Pro Gly Asn Ser Ile Arg Leu His Phe Val His Gly Tyr Arg Gly Tyr 
        675                 680                 685             


Asp Cys Arg Ser Asn Leu Phe Tyr Thr Gln Ile Gly Glu Ile Val Tyr 
    690                 695                 700                 


His Val Ala Ala Val Gly Val Ile Tyr Asn Arg Gln Gln Asn Thr Gln 
705                 710                 715                 720 


Arg Phe Tyr Leu Gly His Asp Asp Asp Ile Leu Cys Leu Thr Ile His 
                725                 730                 735     


Pro Leu Lys Asp Tyr Val Ala Thr Gly Gln Val Gly Arg Asp Pro Ser 
            740                 745                 750         


Ile His Ile Trp Asp Thr Glu Thr Ile Lys Pro Leu Ser Ile Leu Lys 
        755                 760                 765             


Gly His His Gln Tyr Gly Val Ser Ala Val Asp Phe Ser Ala Asp Gly 
    770                 775                 780                 


Lys Arg Leu Ala Ser Val Gly Ile Asp Asp Ser His Thr Val Val Leu 
785                 790                 795                 800 


Trp Asp Trp Lys Lys Gly Glu Lys Leu Ser Ile Ala Arg Gly Ser Lys 
                805                 810                 815     


Asp Lys Ile Phe Val Val Lys Met Asn Pro Tyr Val Pro Asp Lys Leu 
            820                 825                 830         


Ile Thr Ala Gly Ile Lys His Met Lys Phe Trp Arg Lys Ala Gly Gly 
        835                 840                 845             


Gly Leu Ile Gly Arg Lys Gly Tyr Ile Gly Thr Leu Gly Lys Asn Asp 
    850                 855                 860                 


Thr Met Met Cys Ala Val Tyr Gly Trp Thr Glu Glu Met Ala Phe Ser 
865                 870                 875                 880 


Gly Thr Ser Thr Gly Asp Val Cys Ile Trp Arg Asp Ile Phe Leu Val 
                885                 890                 895     


Lys Thr Val Lys Ala His Asp Gly Pro Val Phe Ser Met His Ala Leu 
            900                 905                 910         


Glu Lys Gly Phe Val Thr Gly Gly Lys Asp Gly Ile Val Ala Leu Trp 
        915                 920                 925             


Asp Asp Ser Phe Glu Arg Cys Leu Lys Thr Tyr Ala Ile Lys Arg Ala 
    930                 935                 940                 


Ala Leu Ala Pro Gly Ser Lys Gly Leu Leu Leu Glu Asp Asn Pro Ser 
945                 950                 955                 960 


Ile Arg Ala Ile Ser Leu Gly His Gly His Ile Leu Val Gly Thr Lys 
                965                 970                 975     


Asn Gly Glu Ile Leu Glu Val Asp Lys Ser Gly Pro Ile Thr Leu Leu 
            980                 985                 990         


Val Gln Gly His Met Glu Gly Glu  Val Trp Gly Leu Ala  Thr His Pro 
        995                 1000                 1005             


Tyr Leu  Pro Ile Cys Ala Thr  Val Ser Asp Asp Lys  Thr Leu Arg 
    1010                 1015                 1020             


Ile Trp  Asp Leu Ser Pro Ser  His Cys Met Leu Ala  Val Arg Lys 
    1025                 1030                 1035             


Leu Lys  Lys Gly Gly Arg Cys  Cys Cys Phe Ser Pro  Asp Gly Lys 
    1040                 1045                 1050             


Ala Leu  Ala Val Gly Leu Asn  Asp Gly Ser Phe Leu  Met Ala Asn 
    1055                 1060                 1065             


Ala Asp  Thr Leu Glu Asp Leu  Val Ser Phe His His  Arg Lys Asp 
    1070                 1075                 1080             


Met Ile  Ser Asp Ile Arg Phe  Ser Pro Gly Ser Gly  Lys Tyr Leu 
    1085                 1090                 1095             


Ala Val  Ala Ser His Asp Ser  Phe Ile Asp Ile Tyr  Asn Val Met 
    1100                 1105                 1110             


Ser Ser  Lys Arg Val Gly Ile  Cys Lys Gly Ala Thr  Ser Tyr Ile 
    1115                 1120                 1125             


Thr His  Ile Asp Trp Asp Ile  Arg Gly Lys Leu Leu  Gln Val Asn 
    1130                 1135                 1140             


Thr Gly  Ala Lys Glu Gln Leu  Phe Phe Glu Ala Pro  Arg Gly Lys 
    1145                 1150                 1155             


Lys Gln  Thr Ile Pro Ser Val  Glu Val Glu Lys Ile  Ala Trp Ala 
    1160                 1165                 1170             


Ser Trp  Thr Ser Val Leu Gly  Leu Cys Cys Glu Gly  Ile Trp Pro 
    1175                 1180                 1185             


Val Ile  Gly Glu Val Thr Asp  Val Thr Ala Ser Cys  Leu Thr Ser 
    1190                 1195                 1200             


Asp Lys  Met Val Leu Ala Thr  Gly Asp Asp Leu Gly  Phe Val Lys 
    1205                 1210                 1215             


Leu Phe  Arg Tyr Pro Thr Lys  Gly Lys Phe Gly Lys  Phe Lys Arg 
    1220                 1225                 1230             


Tyr Val  Ala His Ser Thr His  Val Thr Asn Val Arg  Trp Thr Tyr 
    1235                 1240                 1245             


Asp Asp  Ser Met Leu Val Thr  Leu Gly Gly Thr Asp  Met Ser Leu 
    1250                 1255                 1260             


Met Val  Trp Thr Asn Glu Met  Glu Gly Tyr Arg Glu  Lys Arg Pro 
    1265                 1270                 1275             


Cys Asp  Ser Glu Glu Ser Asp  Ile Asp Ser Glu Glu  Asp Gly Gly 
    1280                 1285                 1290             


Tyr Asp  Ser Asp Val Thr Arg  Glu Asn Glu Ile Ser  Tyr Thr Ile 
    1295                 1300                 1305             


Arg Ala  Leu Ser Thr Asn Ile  Arg Pro Met Leu Gly  Ile Lys Pro 
    1310                 1315                 1320             


His Leu  Gln Gln Lys Glu Pro  Ser Ile Asp Glu Arg  Pro Pro Val 
    1325                 1330                 1335             


Ser Arg  Ala Pro Pro Gln Pro  Glu Lys Leu Gln Thr  Asn Asn Val 
    1340                 1345                 1350             


Gly Lys  Lys Lys Arg Pro Ile  Glu Asp Leu Val Leu  Glu Leu Ile 
    1355                 1360                 1365             


Phe Gly  Tyr Arg Gly Arg Asp  Cys Arg Asn Asn Val  His Tyr Leu 
    1370                 1375                 1380             


Asn Asp  Gly Asp Asp Ile Ile  Tyr His Thr Ala Ser  Val Gly Ile 
    1385                 1390                 1395             


Leu His  Asn Val Ala Thr Gly  Ser Gln Ser Phe Tyr  Gln Glu His 
    1400                 1405                 1410             


Asn Asp  Asp Ile Leu Cys Leu  Thr Val Asn Gln His  Pro Lys Phe 
    1415                 1420                 1425             


Ile Asn  Ile Val Ala Thr Gly  Gln Val Gly Asp Ser  Ala Asp Met 
    1430                 1435                 1440             


Ser Ala  Thr Ala Pro Ser Ile  His Ile Trp Asp Ala  Met Asn Lys 
    1445                 1450                 1455             


Gln Thr  Leu Ser Ile Leu Arg  Cys Tyr His Ser Lys  Gly Val Cys 
    1460                 1465                 1470             


Ser Val  Ser Phe Ser Ala Thr  Gly Lys Leu Leu Leu  Ser Val Gly 
    1475                 1480                 1485             


Leu Asp  Pro Glu His Thr Ile  Thr Ile Trp Arg Trp  Gln Glu Gly 
    1490                 1495                 1500             


Ala Lys  Ile Ala Ser Arg Ala  Gly His Asn Gln Arg  Ile Phe Val 
    1505                 1510                 1515             


Ala Glu  Phe Arg Pro Asp Ser  Asp Thr Gln Phe Val  Ser Val Gly 
    1520                 1525                 1530             


Val Lys  His Val Lys Phe Trp  Thr Leu Ala Gly Arg  Ala Leu Leu 
    1535                 1540                 1545             


Ser Lys  Lys Gly Leu Leu Ser  Thr Leu Glu Asp Ala  Arg Met Gln 
    1550                 1555                 1560             


Thr Met  Leu Ala Ile Ala Phe  Gly Ala Asn Asn Leu  Thr Phe Thr 
    1565                 1570                 1575             


Gly Thr  Ile Ser Gly Asp Val  Cys Val Trp Lys Asp  His Ile Leu 
    1580                 1585                 1590             


Cys Arg  Ile Val Ala Arg Ala  His Asn Gly Pro Val  Phe Ala Met 
    1595                 1600                 1605             


Tyr Thr  Thr Leu Arg Asp Gly  Leu Ile Val Thr Gly  Gly Lys Glu 
    1610                 1615                 1620             


Arg Pro  Ser Lys Glu Gly Gly  Ala Val Lys Leu Trp  Asp Gln Glu 
    1625                 1630                 1635             


Leu Arg  Arg Cys Arg Ala Phe  Arg Leu Glu Thr Gly  Gln Ala Thr 
    1640                 1645                 1650             


Asp Cys  Val Arg Ser Val Cys  Arg Gly Lys Gly Lys  Ile Leu Val 
    1655                 1660                 1665             


Gly Thr  Arg Asn Ala Glu Ile  Ile Glu Val Gly Glu  Lys Asn Ala 
    1670                 1675                 1680             


Ala Cys  Asn Ile Leu Val Asn  Gly His Val Asp Gly  Pro Ile Trp 
    1685                 1690                 1695             


Gly Leu  Ala Thr His Pro Ser  Arg Asp Phe Phe Leu  Ser Ala Ala 
    1700                 1705                 1710             


Glu Asp  Gly Thr Val Arg Leu  Trp Asp Ile Ala Asp  Lys Lys Met 
    1715                 1720                 1725             


Leu Asn  Lys Val Asn Leu Gly  His Ala Ala Arg Thr  Val Cys Tyr 
    1730                 1735                 1740             


Ser Pro  Glu Gly Asp Met Val  Ala Ile Gly Met Lys  Asn Gly Glu 
    1745                 1750                 1755             


Phe Ile  Ile Leu Leu Val Ser  Ser Leu Lys Ile Trp  Gly Lys Lys 
    1760                 1765                 1770             


Arg Asp  Arg Arg Cys Ala Ile  His Asp Ile Arg Phe  Ser Pro Asp 
    1775                 1780                 1785             


Ser Arg  Tyr Leu Ala Val Gly  Ser Ser Glu Asn Ser  Val Asp Phe 
    1790                 1795                 1800             


Tyr Asp  Leu Thr Leu Gly Pro  Thr Leu Asn Arg Ile  Ser Tyr Cys 
    1805                 1810                 1815             


Lys Asp  Ile Pro Ser Phe Val  Ile Gln Met Asp Phe  Ser Ala Asp 
    1820                 1825                 1830             


Ser Ser  Tyr Leu Gln Val Ser  Ser Gly Cys Tyr Lys  Arg His Val 
    1835                 1840                 1845             


Tyr Glu  Val Pro Ser Gly Lys  His Leu Met Asp His  Ala Ala Ile 
    1850                 1855                 1860             


Asp Arg  Ile Thr Trp Ala Thr  Trp Thr Ser Ile Leu  Gly Asp Glu 
    1865                 1870                 1875             


Val Leu  Gly Ile Trp Ser Arg  His Ala Glu Lys Ala  Asp Val Asn 
    1880                 1885                 1890             


Cys Ala  Cys Val Ser His Ser  Gly Ile Ser Leu Val  Thr Gly Asp 
    1895                 1900                 1905             


Asp Phe  Gly Met Val Lys Leu  Phe Asp Phe Pro Cys  Pro Glu Lys 
    1910                 1915                 1920             


Phe Ala  Lys His Lys Arg Phe  Leu Gly His Ser Pro  His Val Thr 
    1925                 1930                 1935             


Asn Ile  Arg Phe Thr Ser Gly  Asp Arg His Val Val  Ser Ala Gly 
    1940                 1945                 1950             


Gly Asp  Asp Cys Ser Leu Phe  Val Trp Lys Cys Val  His Thr Pro 
    1955                 1960                 1965             


His 
    


<210> 6638
<211> 381
<212> PRT
<213> Homo sapiens

<400> 6638
Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 
1               5                   10                  15      


Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 
            20                  25                  30          


Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 
        35                  40                  45              


Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 
    50                  55                  60                  


Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 
65                  70                  75                  80  


Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 
                85                  90                  95      


Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 
            100                 105                 110         


Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 
        115                 120                 125             


Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 
    130                 135                 140                 


Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 
145                 150                 155                 160 


Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 
                165                 170                 175     


Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 
            180                 185                 190         


Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 
        195                 200                 205             


Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 
    210                 215                 220                 


Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 
225                 230                 235                 240 


Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 
                245                 250                 255     


Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 
            260                 265                 270         


Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 
        275                 280                 285             


Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 
    290                 295                 300                 


Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 
305                 310                 315                 320 


Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 
                325                 330                 335     


Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Glu Phe Cys 
            340                 345                 350         


Ser Leu Glu Gly Ile Glu Cys Gln Ala Ser Glu Pro Lys Leu Ser His 
        355                 360                 365             


His Ile Pro Ser Asp Leu His Val Tyr Ile Gln Met Ala 
    370                 375                 380     


<210> 6639
<211> 447
<212> PRT
<213> Homo sapiens

<400> 6639
Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
1               5                   10                  15      


Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
            20                  25                  30          


Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
        35                  40                  45              


Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
    50                  55                  60                  


Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
65                  70                  75                  80  


Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                85                  90                  95      


Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
            100                 105                 110         


Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
        115                 120                 125             


Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
    130                 135                 140                 


Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
145                 150                 155                 160 


Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                165                 170                 175     


Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
            180                 185                 190         


Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
        195                 200                 205             


Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
    210                 215                 220                 


Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
225                 230                 235                 240 


Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                245                 250                 255     


Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
            260                 265                 270         


Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
        275                 280                 285             


Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
    290                 295                 300                 


Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
305                 310                 315                 320 


Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                325                 330                 335     


Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
            340                 345                 350         


Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
        355                 360                 365             


Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
    370                 375                 380                 


Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
385                 390                 395                 400 


Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                405                 410                 415     


Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
            420                 425                 430         


Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
        435                 440                 445         


<210> 6640
<211> 470
<212> PRT
<213> Homo sapiens

<400> 6640
Met Asp Leu Arg Asp Gln Glu Leu Val Lys Ile Val Gly Ile Arg Tyr 
1               5                   10                  15      


Glu Val Gly Pro Pro Thr Leu Cys Cys Leu Lys Leu Ala Phe Ile Asp 
            20                  25                  30          


Pro Ala Thr Gly Lys Leu Met Asp Lys Ser Phe Ser Ile Arg Tyr His 
        35                  40                  45              


Asp Met Pro Asp Val Ile Asp Phe Leu Val Leu Arg Gln Phe Tyr Asp 
    50                  55                  60                  


Glu Ala Arg Gln Arg Asn Trp Gln Ser Cys Asp Arg Phe Arg Ser Ile 
65                  70                  75                  80  


Ile Asp Asp Ala Trp Trp Phe Gly Thr Val Leu Ser Gln Glu Pro Tyr 
                85                  90                  95      


Gln Pro Gln Tyr Pro Asp Ser His Phe Gln Cys Tyr Ile Val Arg Trp 
            100                 105                 110         


Asp Asn Thr Glu Ile Glu Lys Leu Ser Pro Trp Asp Met Glu Pro Ile 
        115                 120                 125             


Pro Asp Asn Val Asp Pro Pro Glu Glu Leu Gly Ala Ser Ile Ser Val 
    130                 135                 140                 


Thr Thr Asp Glu Leu Glu Lys Leu Leu Tyr Lys Pro Gln Ala Gly Glu 
145                 150                 155                 160 


Trp Gly Gln Lys Ser Arg Asp Glu Glu Cys Asp Arg Ile Ile Ser Gly 
                165                 170                 175     


Ile Asp Gln Leu Leu Asn Leu Asp Ile Ala Ala Ala Phe Ala Gly Pro 
            180                 185                 190         


Val Asp Leu Cys Thr Tyr Pro Lys Tyr Cys Thr Val Val Ala Tyr Pro 
        195                 200                 205             


Thr Asp Leu Tyr Thr Ile Arg Met Arg Leu Val Asn Arg Phe Tyr Arg 
    210                 215                 220                 


Arg Leu Ser Ala Leu Val Trp Glu Val Arg Tyr Ile Glu His Asn Ala 
225                 230                 235                 240 


Arg Thr Phe Asn Glu Pro Glu Ser Val Ile Ala Arg Ser Ala Lys Lys 
                245                 250                 255     


Ile Thr Asp Gln Leu Leu Lys Phe Ile Lys Asn Gln His Cys Thr Asn 
            260                 265                 270         


Ile Ser Glu Leu Ser Asn Thr Ser Glu Asn Asp Glu Gln Asn Ala Glu 
        275                 280                 285             


Asp Leu Asp Asp Ser Asp Leu Pro Lys Thr Ser Ser Gly Arg Arg Arg 
    290                 295                 300                 


Asp Tyr Arg Asp Ile Ile Asp Thr Pro Met Asp Phe Gly Thr Val Arg 
305                 310                 315                 320 


Glu Thr Leu Asp Ala Gly Asn Tyr Asp Ser Pro Leu Glu Phe Cys Lys 
                325                 330                 335     


Asp Ile Arg Leu Ile Phe Ser Asn Ala Lys Ala Tyr Thr Pro Asn Lys 
            340                 345                 350         


Arg Ser Lys Ile Tyr Ser Met Thr Leu Arg Leu Ser Ala Leu Phe Glu 
        355                 360                 365             


Glu Lys Met Lys Lys Ile Ser Ser Asp Phe Lys Ile Gly Gln Lys Phe 
    370                 375                 380                 


Asn Glu Lys Leu Arg Arg Ser Gln Arg Phe Lys Gln Arg Gln Asn Cys 
385                 390                 395                 400 


Lys Gly Asp Ser Gln Pro Asn Lys Ser Ile Arg Asn Leu Lys Pro Lys 
                405                 410                 415     


Arg Leu Lys Ser Gln Thr Lys Ile Ile Pro Glu Leu Val Gly Ser Pro 
            420                 425                 430         


Thr Gln Ser Thr Ser Ser Arg Thr Ala Tyr Leu Gly Thr His Lys Thr 
        435                 440                 445             


Ser Ala Gly Ile Ser Ser Gly Val Thr Ser Gly Leu Phe Arg Phe Ser 
    450                 455                 460                 


Arg Ile Ile Arg Lys Glu 
465                 470 


<210> 6641
<211> 171
<212> PRT
<213> Homo sapiens

<400> 6641
Met Cys Gly Arg Ala Pro Pro Pro Glu Ile Thr Gly Arg Glu Pro Gly 
1               5                   10                  15      


Tyr His Leu Val Glu Gln Ser Cys Trp Leu Lys Pro Leu Pro Arg Asn 
            20                  25                  30          


Leu Gly His Ser Leu Phe Trp Thr Val Trp Lys Pro Arg Pro Val Ser 
        35                  40                  45              


Gln Leu Val Ala Gln Gln Val Thr Gln Gln Phe Val Pro Pro Thr Gln 
    50                  55                  60                  


Ser Lys Lys Glu Lys Lys Asp Lys Val Glu Lys Glu Lys Ser Glu Lys 
65                  70                  75                  80  


Glu Thr Thr Ser Lys Lys Asn Ser His Lys Lys Thr Arg Pro Arg Leu 
                85                  90                  95      


Lys Asn Val Asp Arg Ser Ser Ala Gln His Leu Glu Val Thr Val Gly 
            100                 105                 110         


Asp Leu Thr Val Ile Ile Thr Asp Phe Lys Glu Lys Thr Lys Ser Pro 
        115                 120                 125             


Pro Ala Ser Ser Ala Ala Ser Ala Asp Gln His Ser Gln Ser Gly Ser 
    130                 135                 140                 


Ser Ser Asp Asn Thr Glu Arg Gly Met Ser Arg Ser Ser Ser Pro Arg 
145                 150                 155                 160 


Gly Glu Ala Ser Ser Leu Asn Gly Glu Ser His 
                165                 170     


<210> 6642
<211> 138
<212> PRT
<213> Homo sapiens

<400> 6642
Met Gly Asp Lys Lys Ser Pro Thr Arg Lys Pro Arg Pro Val Ser Gln 
1               5                   10                  15      


Leu Val Ala Gln Gln Val Thr Gln Gln Phe Val Pro Pro Thr Gln Ser 
            20                  25                  30          


Lys Lys Glu Lys Lys Asp Lys Val Glu Lys Glu Lys Ser Glu Lys Glu 
        35                  40                  45              


Thr Thr Ser Lys Lys Asn Ser His Lys Lys Thr Arg Pro Arg Leu Lys 
    50                  55                  60                  


Asn Val Asp Arg Ser Ser Ala Gln His Leu Glu Val Thr Val Gly Asp 
65                  70                  75                  80  


Leu Thr Val Ile Ile Thr Asp Phe Lys Glu Lys Thr Lys Ser Pro Pro 
                85                  90                  95      


Ala Ser Ser Ala Ala Ser Ala Asp Gln His Ser Gln Ser Gly Ser Ser 
            100                 105                 110         


Ser Asp Asn Thr Glu Arg Gly Met Ser Arg Ser Ser Ser Pro Arg Gly 
        115                 120                 125             


Glu Ala Ser Ser Leu Asn Gly Glu Ser His 
    130                 135             


<210> 6643
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6643
Met Gly His Cys Cys Cys Lys Pro Tyr Asn Cys Leu Gln Cys Leu Asp 
1               5                   10                  15      


Lys Thr Asn Glu Ser Ala Leu Val Lys Glu Lys Glu Leu Ser Ile Glu 
            20                  25                  30          


Leu Ala Asn Ile Arg Asp Glu Val Ala Phe His Thr Ala Lys Cys Glu 
        35                  40                  45              


Lys Leu Gln Lys Glu Lys Glu Glu Leu Glu Arg Arg Phe Glu Asp Glu 
    50                  55                  60                  


Val Lys Arg Leu Gly Trp Gln Gln Gln Ala Glu Leu Gln Glu Leu Glu 
65                  70                  75                  80  


Glu Arg Leu Gln Leu Gln Phe Glu Ala Glu Met Ala Arg Leu Gln Glu 
                85                  90                  95      


Glu His Gly Asp Gln Leu Leu Ser Ile Arg Cys Gln His Gln Glu Gln 
            100                 105                 110         


Val Glu Asp Leu Thr Ala Ser His Asp Ala Ala Leu Leu Glu Met Glu 
        115                 120                 125             


Asn Asn His Thr Val Ala Ile Thr Ile Leu Gln Asp Asp His Asp His 
    130                 135                 140                 


Lys Val Gln Glu Leu Met Ser Thr His Glu Leu Glu Lys Lys Glu Leu 
145                 150                 155                 160 


Glu Glu Asn Phe Glu Lys Leu Arg Leu Ser Leu Gln Asp Gln Val Asp 
                165                 170                 175     


Thr Leu Thr Phe Gln Ser Gln Ser Leu Arg Asp Arg Ala Arg Arg Phe 
            180                 185                 190         


Glu Glu Ala Leu Arg Lys Asn Thr Glu Glu Gln Leu Glu Ile Ala Leu 
        195                 200                 205             


Ala Pro Tyr Gln His Leu Glu Glu Asp Met Lys Ser Leu Lys Gln Val 
    210                 215                 220                 


Leu Glu Met Lys Asn Gln Gln Ile His Glu Gln Glu Lys Lys Ile Leu 
225                 230                 235                 240 


Glu Leu Glu Lys Leu Ala Glu Lys Asn Ile Ile Leu Glu Glu Lys Ile 
                245                 250                 255     


Gln Val Leu Gln Gln Gln Asn Glu Asp Leu Lys Ala Arg Ile Asp Gln 
            260                 265                 270         


Asn Thr Val Val Thr Arg Gln Leu Ser Glu Glu Asn Ala Asn Leu Gln 
        275                 280                 285             


Glu Tyr Val Glu Lys Glu Thr Gln Glu Lys Lys Arg Leu Ser Arg Thr 
    290                 295                 300                 


Asn Glu Glu Leu Leu Trp Lys Leu Gln Thr Gly Asp Pro Thr Ser Pro 
305                 310                 315                 320 


Ile Lys Leu Ser Pro Thr Ser Pro Val Tyr Arg Gly Ser Ser Ser Gly 
                325                 330                 335     


Pro Ser Ser Pro Ala Arg Val Ser Thr Thr Pro Arg 
            340                 345             


<210> 6644
<211> 887
<212> PRT
<213> Homo sapiens

<400> 6644
Met Asn Ser Gly Gly Gly Leu Pro Pro Pro Ser Ala Ala Ala Ser Pro 
1               5                   10                  15      


Ser Ser Ser Ser Leu Ala Ala Ala Val Ala Val Val Ala Pro Pro Gly 
            20                  25                  30          


Val Gly Gly Val Pro Gly Gly Ala Ala Val Gly Val Lys Leu Lys Tyr 
        35                  40                  45              


Cys Arg Tyr Tyr Ala Lys Asp Lys Thr Cys Phe Tyr Gly Glu Glu Cys 
    50                  55                  60                  


Gln Phe Leu His Glu Asp Pro Ala Ala Gly Ala Ala Pro Gly Leu Gly 
65                  70                  75                  80  


Leu His Ser Asn Ser Val Pro Leu Ala Leu Ala Gly Ala Pro Val Ala 
                85                  90                  95      


Gly Phe Pro Pro Gly Ala Val Ala Gly Gly Gly Ala Gly Pro Pro Pro 
            100                 105                 110         


Gly Pro Lys Lys Pro Asp Leu Gly Asp Pro Gly Thr Gly Ala Ala Ala 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Gly Gly Leu Asp Gly Pro Arg Leu Ala Ile 
    130                 135                 140                 


Pro Gly Met Asp Gly Gly Ala Leu Thr Asp Thr Ser Leu Thr Asp Ser 
145                 150                 155                 160 


Tyr Phe Ser Thr Ser Phe Ile Gly Val Asn Gly Phe Gly Ser Pro Val 
                165                 170                 175     


Glu Thr Lys Tyr Pro Leu Met Gln Arg Met Thr Asn Ser Ser Ser Ser 
            180                 185                 190         


Pro Ser Leu Leu Asn Asp Ser Ala Lys Pro Tyr Ser Ala His Asp Pro 
        195                 200                 205             


Leu Thr Ser Pro Ala Ser Ser Leu Phe Asn Asp Phe Gly Ala Leu Asn 
    210                 215                 220                 


Ile Ser Gln Arg Arg Lys Pro Arg Lys Tyr Arg Leu Gly Met Leu Glu 
225                 230                 235                 240 


Glu Arg Leu Val Pro Met Gly Ser Lys Ala Arg Lys Ala Lys Asn Pro 
                245                 250                 255     


Ile Gly Cys Leu Ala Asp Arg Cys Lys Ser Gly Val Pro Ile Asn Met 
            260                 265                 270         


Val Trp Trp Asn Arg Val Thr Glu Asn Asn Leu Gln Thr Pro Asn Pro 
        275                 280                 285             


Thr Ala Ser Glu Phe Ile Pro Lys Gly Gly Ser Thr Ser Arg Leu Ser 
    290                 295                 300                 


Asn Val Ser Gln Ser Asn Met Ser Ala Phe Ser Gln Val Phe Ser His 
305                 310                 315                 320 


Pro Ser Met Gly Ser Pro Ala Thr Ala Gly Leu Ala Pro Gly Met Ser 
                325                 330                 335     


Leu Ser Ala Gly Ser Ser Pro Leu His Ser Pro Lys Ile Thr Pro His 
            340                 345                 350         


Thr Ser Pro Ala Pro Arg Arg Arg Ser His Thr Pro Asn Pro Ala Ser 
        355                 360                 365             


Tyr Met Val Pro Ser Ser Ala Ser Thr Ser Val Asn Asn Pro Val Ser 
    370                 375                 380                 


Gln Thr Pro Ser Ser Gly Gln Val Ile Gln Lys Glu Thr Val Gly Gly 
385                 390                 395                 400 


Thr Thr Tyr Phe Tyr Thr Asp Thr Thr Pro Ala Pro Leu Thr Gly Met 
                405                 410                 415     


Val Phe Pro Asn Tyr His Ile Tyr Pro Pro Thr Ala Pro His Val Ala 
            420                 425                 430         


Tyr Met Gln Pro Lys Ala Asn Ala Pro Ser Phe Phe Met Ala Asp Glu 
        435                 440                 445             


Leu Arg Gln Glu Leu Ile Asn Arg His Leu Ile Thr Met Ala Gln Ile 
    450                 455                 460                 


Asp Gln Ala Asp Met Pro Ala Val Pro Thr Glu Val Asp Ser Tyr His 
465                 470                 475                 480 


Ser Leu Phe Pro Leu Glu Pro Leu Pro Pro Pro Asn Arg Ile Gln Lys 
                485                 490                 495     


Ser Ser Asn Phe Gly Tyr Ile Thr Ser Cys Tyr Lys Ala Val Asn Ser 
            500                 505                 510         


Lys Asp Asp Leu Pro Tyr Cys Leu Arg Arg Ile His Gly Phe Arg Leu 
        515                 520                 525             


Val Asn Thr Lys Cys Met Val Leu Val Asp Met Trp Lys Lys Ile Gln 
    530                 535                 540                 


His Ser Asn Ile Val Thr Leu Arg Glu Val Phe Thr Thr Lys Ala Phe 
545                 550                 555                 560 


Ala Glu Pro Ser Leu Val Phe Ala Tyr Asp Phe His Ala Gly Gly Glu 
                565                 570                 575     


Thr Met Met Ser Arg His Phe Asn Asp Pro Asn Ala Asp Ala Tyr Phe 
            580                 585                 590         


Thr Lys Arg Lys Trp Gly Gln His Glu Gly Pro Leu Pro Arg Gln His 
        595                 600                 605             


Ala Gly Leu Leu Pro Glu Ser Leu Ile Trp Ala Tyr Ile Val Gln Leu 
    610                 615                 620                 


Ser Ser Ala Leu Arg Thr Ile His Thr Ala Gly Leu Ala Cys Arg Val 
625                 630                 635                 640 


Met Asp Pro Thr Lys Ile Leu Ile Thr Gly Lys Thr Arg Leu Arg Val 
                645                 650                 655     


Asn Cys Val Gly Val Phe Asp Val Leu Thr Phe Asp Asn Ser Gln Asn 
            660                 665                 670         


Asn Asn Pro Leu Ala Leu Met Ala Gln Tyr Gln Gln Ala Asp Leu Ile 
        675                 680                 685             


Ser Leu Gly Lys Val Val Leu Ala Leu Ala Cys Asn Ser Leu Ala Gly 
    690                 695                 700                 


Ile Gln Arg Glu Asn Leu Gln Lys Ala Met Glu Leu Val Thr Ile Asn 
705                 710                 715                 720 


Tyr Ser Ser Asp Leu Lys Asn Leu Ile Leu Tyr Leu Leu Thr Asp Gln 
                725                 730                 735     


Asn Arg Met Arg Ser Val Asn Asp Ile Met Pro Met Ile Gly Ala Arg 
            740                 745                 750         


Phe Tyr Thr Gln Leu Asp Ala Ala Gln Met Arg Asn Asp Val Ile Glu 
        755                 760                 765             


Glu Asp Leu Ala Lys Glu Val Gln Asn Gly Arg Leu Phe Arg Leu Leu 
    770                 775                 780                 


Ala Lys Leu Gly Thr Ile Asn Glu Arg Pro Glu Phe Gln Lys Asp Pro 
785                 790                 795                 800 


Thr Trp Ser Glu Thr Gly Asp Arg Tyr Leu Leu Lys Leu Phe Arg Asp 
                805                 810                 815     


His Leu Phe His Gln Val Thr Glu Ala Gly Ala Pro Trp Ile Asp Leu 
            820                 825                 830         


Ser His Ile Ile Ser Cys Leu Asn Lys Leu Asp Ala Gly Val Pro Glu 
        835                 840                 845             


Lys Ile Ser Leu Ile Ser Arg Asp Glu Lys Ser Val Leu Val Val Thr 
    850                 855                 860                 


Tyr Ser Asp Leu Lys Arg Cys Phe Glu Asn Thr Phe Gln Glu Leu Ile 
865                 870                 875                 880 


Ala Ala Ala Asn Gly Gln Leu 
                885         


<210> 6645
<211> 569
<212> PRT
<213> Homo sapiens

<400> 6645
Met Ala Thr Leu Val Val Asn Lys Leu Gly Ala Gly Val Asp Ser Gly 
1               5                   10                  15      


Arg Gln Gly Ser Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly 
            20                  25                  30          


Val Cys Glu Asp Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu 
        35                  40                  45              


Leu Leu Cys Gly His Thr Val Cys His Asp Cys Leu Thr Arg Leu Pro 
    50                  55                  60                  


Leu His Gly Arg Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp 
65                  70                  75                  80  


Leu Gly Asp Ser Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu 
                85                  90                  95      


Glu Leu Leu Glu Arg Leu Gln Asn Gly Pro Ile Gly Gln Tyr Gly Ala 
            100                 105                 110         


Ala Glu Glu Ser Ile Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp 
        115                 120                 125             


Glu Asp Glu Ala His Leu Ala Ser Val Tyr Cys Thr Val Cys Ala Thr 
    130                 135                 140                 


His Leu Cys Ser Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu 
145                 150                 155                 160 


Ala Lys His Arg Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr 
                165                 170                 175     


Met Cys Ser Gln His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu 
            180                 185                 190         


Glu Gly Cys Gln Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr 
        195                 200                 205             


Gly Lys His Gln Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn 
    210                 215                 220                 


Gln Ile Arg Ala Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe 
225                 230                 235                 240 


Thr Glu Glu Ile Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln 
                245                 250                 255     


His Ile Glu Gly Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala 
            260                 265                 270         


His Thr Glu His Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Ile 
        275                 280                 285             


Arg Ala Tyr Phe Tyr Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu 
    290                 295                 300                 


Met Ala Leu Ser Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp 
305                 310                 315                 320 


Leu Arg Gln Gln Gln Glu Asp Met Thr Ile Leu Leu Ser Glu Val Ser 
                325                 330                 335     


Ala Ala Cys Leu His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg 
            340                 345                 350         


Val Val Leu Ala Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln 
        355                 360                 365             


Lys Gln Gln Gln Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp 
    370                 375                 380                 


Ala Ser Ile Pro Val Thr Phe Thr Lys Asp Asn Arg Val His Ile Gly 
385                 390                 395                 400 


Pro Lys Met Glu Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly 
                405                 410                 415     


Lys Thr Thr Ile Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro 
            420                 425                 430         


Ile Pro Thr Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu 
        435                 440                 445             


Lys Phe Thr Ile Trp Asp Val Gly Gly Lys His Lys Leu Arg Pro Leu 
    450                 455                 460                 


Trp Lys His Tyr Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp 
465                 470                 475                 480 


Ser Ser His Arg Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys 
                485                 490                 495     


Leu Leu Thr Glu Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala 
            500                 505                 510         


Asn Lys Gln Asp Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu 
        515                 520                 525             


Leu Leu Ser Leu His Lys Leu Cys Cys Gly Arg Ser Trp Tyr Ile Gln 
    530                 535                 540                 


Gly Cys Asp Ala Arg Ser Val Phe Gln Ile Ile Cys Asp Gln Tyr Thr 
545                 550                 555                 560 


Gly Lys Glu Val Val Thr Glu Lys Gly 
                565                 


<210> 6646
<211> 686
<212> PRT
<213> Homo sapiens

<400> 6646
Met Gly Arg Ile His Gln Ala Met Val Thr Ser Leu Asn Glu Asp Asn 
1               5                   10                  15      


Glu Ser Val Thr Val Glu Trp Ile Glu Asn Gly Asp Thr Lys Gly Lys 
            20                  25                  30          


Glu Ile Asp Leu Glu Ser Ile Phe Ser Leu Asn Pro Asp Leu Val Pro 
        35                  40                  45              


Asp Glu Glu Ile Glu Pro Ser Pro Glu Thr Pro Pro Pro Pro Ala Ser 
    50                  55                  60                  


Ser Ala Lys Val Asn Lys Ile Val Lys Asn Arg Arg Thr Val Ala Ser 
65                  70                  75                  80  


Ile Lys Asn Asp Pro Pro Ser Arg Asp Asn Arg Val Val Gly Ser Ala 
                85                  90                  95      


Arg Ala Arg Pro Ser Gln Phe Pro Glu Gln Ser Ser Ser Ala Gln Gln 
            100                 105                 110         


Asn Gly Ser Val Ser Asp Ile Ser Pro Val Gln Ala Ala Lys Lys Glu 
        115                 120                 125             


Phe Gly Pro Pro Ser Arg Arg Lys Ser Asn Cys Val Lys Glu Val Glu 
    130                 135                 140                 


Lys Leu Gln Glu Lys Arg Glu Lys Arg Arg Leu Gln Gln Gln Glu Leu 
145                 150                 155                 160 


Arg Glu Lys Arg Ala Gln Asp Val Asp Ala Thr Asn Pro Asn Tyr Glu 
                165                 170                 175     


Ile Met Cys Met Ile Arg Asp Phe Arg Gly Ser Leu Asp Tyr Arg Pro 
            180                 185                 190         


Leu Thr Thr Ala Asp Pro Ile Asp Glu His Arg Ile Cys Val Cys Val 
        195                 200                 205             


Arg Lys Arg Pro Leu Asn Lys Lys Glu Thr Gln Met Lys Asp Leu Asp 
    210                 215                 220                 


Val Ile Thr Ile Pro Ser Lys Asp Val Val Met Val His Glu Pro Lys 
225                 230                 235                 240 


Gln Lys Val Asp Leu Thr Arg Tyr Leu Glu Asn Gln Thr Phe Arg Phe 
                245                 250                 255     


Asp Tyr Ala Phe Asp Asp Ser Ala Pro Asn Glu Met Val Tyr Arg Phe 
            260                 265                 270         


Thr Ala Arg Pro Leu Val Glu Thr Ile Phe Glu Arg Gly Met Ala Thr 
        275                 280                 285             


Cys Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr His Thr Met Gly 
    290                 295                 300                 


Gly Asp Phe Ser Gly Lys Asn Gln Asp Cys Ser Lys Gly Ile Tyr Ala 
305                 310                 315                 320 


Leu Ala Ala Arg Asp Val Phe Leu Met Leu Lys Lys Pro Asn Tyr Lys 
                325                 330                 335     


Lys Leu Glu Leu Gln Val Tyr Ala Thr Phe Phe Glu Ile Tyr Ser Gly 
            340                 345                 350         


Lys Val Phe Asp Leu Leu Asn Arg Lys Thr Lys Leu Arg Val Leu Glu 
        355                 360                 365             


Asp Gly Lys Gln Gln Val Gln Val Val Gly Leu Gln Glu Arg Glu Val 
    370                 375                 380                 


Lys Cys Val Glu Asp Val Leu Lys Leu Ile Asp Ile Gly Asn Ser Cys 
385                 390                 395                 400 


Arg Thr Ser Gly Gln Thr Ser Ala Asn Ala His Ser Ser Arg Ser His 
                405                 410                 415     


Ala Val Phe Gln Ile Ile Leu Arg Arg Lys Gly Lys Leu His Gly Lys 
            420                 425                 430         


Phe Ser Leu Ile Asp Leu Ala Gly Asn Glu Arg Gly Ala Asp Thr Ser 
        435                 440                 445             


Ser Ala Asp Arg Gln Thr Arg Leu Glu Gly Ala Glu Ile Asn Lys Ser 
    450                 455                 460                 


Leu Leu Ala Leu Lys Glu Cys Ile Arg Ala Leu Gly Arg Asn Lys Pro 
465                 470                 475                 480 


His Thr Pro Phe Arg Ala Ser Lys Leu Thr Gln Val Leu Arg Asp Ser 
                485                 490                 495     


Phe Ile Gly Glu Asn Ser Arg Thr Cys Met Ile Ala Thr Ile Ser Pro 
            500                 505                 510         


Gly Met Ala Ser Cys Glu Asn Thr Leu Asn Thr Leu Arg Tyr Ala Asn 
        515                 520                 525             


Arg Val Lys Glu Leu Thr Val Asp Pro Thr Ala Ala Gly Asp Val Arg 
    530                 535                 540                 


Pro Ile Met His His Pro Pro Asn Gln Ile Asp Asp Leu Glu Thr Gln 
545                 550                 555                 560 


Trp Gly Val Gly Ser Ser Pro Gln Arg Asp Asp Leu Lys Leu Leu Cys 
                565                 570                 575     


Glu Gln Asn Glu Glu Glu Val Ser Pro Gln Leu Phe Thr Phe His Glu 
            580                 585                 590         


Ala Val Ser Gln Met Val Glu Met Glu Glu Gln Val Val Glu Asp His 
        595                 600                 605             


Arg Ala Val Phe Gln Glu Ser Ile Arg Trp Leu Glu Asp Glu Lys Ala 
    610                 615                 620                 


Leu Leu Glu Met Thr Glu Glu Val Asp Tyr Asp Val Asp Ser Tyr Ala 
625                 630                 635                 640 


Thr Gln Leu Glu Ala Ile Leu Glu Gln Lys Ile Asp Ile Leu Thr Glu 
                645                 650                 655     


Leu Arg Asp Lys Val Lys Ser Phe Arg Ala Ala Leu Gln Glu Glu Glu 
            660                 665                 670         


Gln Ala Ser Lys Gln Ile Asn Pro Lys Arg Pro Arg Ala Leu 
        675                 680                 685     


<210> 6647
<211> 205
<212> PRT
<213> Homo sapiens

<400> 6647
Met Ser Val Asp Pro Met Thr Tyr Glu Ala Gln Phe Phe Gly Phe Thr 
1               5                   10                  15      


Pro Gln Thr Cys Met Leu Arg Ile Tyr Ile Ala Phe Gln Asp Tyr Leu 
            20                  25                  30          


Phe Glu Val Met Gln Ala Val Glu Gln Val Ile Leu Lys Lys Leu Asp 
        35                  40                  45              


Gly Ile Pro Asp Cys Asp Ile Ser Pro Val Gln Ile Arg Lys Cys Thr 
    50                  55                  60                  


Glu Lys Phe Leu Cys Phe Met Lys Gly His Phe Asp Asn Leu Phe Ser 
65                  70                  75                  80  


Lys Met Glu Gln Leu Phe Leu Gln Leu Ile Leu Arg Ile Pro Ser Asn 
                85                  90                  95      


Ile Leu Leu Pro Glu Asp Lys Cys Lys Glu Thr Pro Tyr Ser Glu Glu 
            100                 105                 110         


Asp Phe Gln His Leu Gln Lys Glu Ile Glu Gln Leu Gln Glu Lys Tyr 
        115                 120                 125             


Lys Thr Glu Leu Cys Thr Lys Gln Ala Leu Leu Ala Glu Leu Glu Glu 
    130                 135                 140                 


Gln Lys Ile Val Gln Ala Lys Leu Lys Gln Thr Leu Thr Phe Phe Asp 
145                 150                 155                 160 


Glu Leu His Asn Val Gly Arg Asp His Gly Thr Ser Asp Phe Arg Glu 
                165                 170                 175     


Ser Leu Val Ser Leu Val Gln Asn Ser Arg Lys Leu Gln Asn Ile Arg 
            180                 185                 190         


Asp Asn Val Glu Lys Glu Ser Lys Arg Leu Lys Ile Ser 
        195                 200                 205 


<210> 6648
<211> 621
<212> PRT
<213> Homo sapiens

<400> 6648
Met Val Leu Cys Pro Val Ile Gly Lys Leu Leu His Lys Arg Val Val 
1               5                   10                  15      


Leu Ala Ser Ala Ser Pro Arg Arg Gln Glu Ile Leu Ser Asn Ala Gly 
            20                  25                  30          


Leu Arg Phe Glu Val Val Pro Ser Lys Phe Lys Glu Lys Leu Asp Lys 
        35                  40                  45              


Ala Ser Phe Ala Thr Pro Tyr Gly Tyr Ala Met Glu Thr Ala Lys Gln 
    50                  55                  60                  


Lys Ala Leu Glu Val Ala Asn Arg Leu Tyr Gln Lys Asp Leu Arg Ala 
65                  70                  75                  80  


Pro Asp Val Val Ile Gly Ala Asp Thr Ile Val Thr Val Gly Gly Leu 
                85                  90                  95      


Ile Leu Glu Lys Pro Val Asp Lys Gln Asp Ala Tyr Arg Met Leu Ser 
            100                 105                 110         


Arg Leu Ser Gly Arg Glu His Ser Val Phe Thr Gly Val Ala Ile Val 
        115                 120                 125             


His Cys Ser Ser Lys Asp His Gln Leu Asp Thr Arg Val Ser Glu Phe 
    130                 135                 140                 


Tyr Glu Glu Thr Lys Val Lys Phe Ser Glu Leu Ser Glu Glu Leu Leu 
145                 150                 155                 160 


Trp Glu Tyr Val His Ser Gly Glu Pro Met Asp Lys Ala Gly Gly Tyr 
                165                 170                 175     


Gly Ile Gln Ala Leu Gly Gly Met Leu Val Glu Ser Val His Gly Asp 
            180                 185                 190         


Phe Leu Asn Val Val Gly Phe Pro Leu Asn His Phe Cys Lys Gln Leu 
        195                 200                 205             


Val Lys Leu Tyr Tyr Pro Pro Arg Pro Glu Asp Leu Arg Arg Ser Val 
    210                 215                 220                 


Lys His Asp Ser Ile Pro Ala Ala Asp Thr Phe Glu Asp Leu Ser Asp 
225                 230                 235                 240 


Val Glu Gly Gly Gly Ser Glu Pro Thr Gln Arg Asp Ala Gly Ser Arg 
                245                 250                 255     


Asp Glu Lys Ala Glu Ala Gly Glu Ala Gly Gln Ala Thr Ala Glu Ala 
            260                 265                 270         


Glu Cys His Arg Thr Arg Glu Thr Leu Pro Pro Phe Pro Thr Arg Leu 
        275                 280                 285             


Leu Glu Leu Ile Glu Gly Phe Met Leu Ser Lys Gly Leu Leu Thr Ala 
    290                 295                 300                 


Cys Lys Leu Lys Val Phe Asp Leu Leu Lys Asp Glu Ala Pro Gln Lys 
305                 310                 315                 320 


Ala Ala Asp Ile Ala Ser Lys Val Asp Ala Ser Ala Cys Gly Met Glu 
                325                 330                 335     


Arg Leu Leu Asp Ile Cys Ala Ala Met Gly Leu Leu Glu Lys Thr Glu 
            340                 345                 350         


Gln Gly Tyr Ser Asn Thr Glu Thr Ala Asn Val Tyr Leu Ala Ser Asp 
        355                 360                 365             


Gly Glu Tyr Ser Leu His Gly Phe Ile Met His Asn Asn Asp Leu Thr 
    370                 375                 380                 


Trp Asn Leu Phe Thr Tyr Leu Glu Phe Ala Ile Arg Glu Gly Thr Asn 
385                 390                 395                 400 


Gln His His Arg Ala Leu Gly Lys Lys Ala Glu Asp Leu Phe Gln Asp 
                405                 410                 415     


Ala Tyr Tyr Gln Ser Pro Glu Thr Arg Leu Arg Phe Met Arg Ala Met 
            420                 425                 430         


His Gly Met Thr Lys Leu Thr Ala Cys Gln Val Ala Thr Ala Phe Asn 
        435                 440                 445             


Leu Ser Arg Phe Ser Ser Ala Cys Asp Val Gly Gly Cys Thr Gly Ala 
    450                 455                 460                 


Leu Ala Arg Glu Leu Ala Arg Glu Tyr Pro Arg Met Gln Val Thr Val 
465                 470                 475                 480 


Phe Asp Leu Pro Asp Ile Ile Glu Leu Ala Ala His Phe Gln Pro Pro 
                485                 490                 495     


Gly Pro Gln Ala Val Gln Ile His Phe Ala Ala Gly Asp Phe Phe Arg 
            500                 505                 510         


Asp Pro Leu Pro Ser Ala Glu Leu Tyr Val Leu Cys Arg Ile Leu His 
        515                 520                 525             


Asp Trp Pro Asp Asp Lys Val His Lys Leu Leu Ser Arg Val Ala Glu 
    530                 535                 540                 


Ser Cys Lys Pro Gly Ala Gly Leu Leu Leu Val Glu Thr Leu Leu Asp 
545                 550                 555                 560 


Glu Glu Lys Arg Val Ala Gln Arg Ala Leu Met Gln Ser Leu Asn Met 
                565                 570                 575     


Leu Val Gln Thr Glu Gly Lys Glu Arg Ser Leu Gly Glu Tyr Gln Cys 
            580                 585                 590         


Leu Leu Glu Leu His Gly Phe His Gln Val Gln Val Val His Leu Gly 
        595                 600                 605             


Gly Val Leu Asp Ala Ile Leu Ala Thr Lys Val Ala Pro 
    610                 615                 620     


<210> 6649
<211> 846
<212> PRT
<213> Homo sapiens

<400> 6649
Met Leu Phe Thr Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Thr Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Thr Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Thr Phe Leu Ser Asn Glu Glu Phe Thr Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Thr Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Thr Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Thr His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Thr Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Thr Ile Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Thr Tyr Glu Tyr Val Lys Phe Ile Gly Asn Phe Lys Ser Leu Asn Ser 
    210                 215                 220                 


Val Ser Ser Ser Ala His Asn Gly Phe Glu Gly Thr Ile Gln Arg Thr 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Thr Val Arg 
                245                 250                 255     


Leu Ala Thr Pro Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Glu Thr Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Thr Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Thr Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Thr Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Thr Pro Thr Lys Ile Pro Thr Asp Thr Ser Thr Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Val Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Ile Asn Ser Gln Ser Val Gly Ser Ser Leu Thr Gln 
                485                 490                 495     


Pro Val Met Ser Gln Ala Thr Asn Leu Pro Ile Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Thr Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Ser Asn Ile Gln Gln Leu 
            580                 585                 590         


Ala Pro Ile Asn Met Gln Gly Gln Val Val Pro Thr Asn Gln Ile Gln 
        595                 600                 605             


Ser Gly Met Asn Thr Gly His Ile Gly Thr Thr Gln His Met Ile Gln 
    610                 615                 620                 


Gln Gln Thr Leu Gln Ser Thr Ser Thr Gln Ser Gln Gln Asn Val Leu 
625                 630                 635                 640 


Ser Gly His Ser Gln Gln Thr Ser Leu Pro Ser Gln Thr Gln Ser Thr 
                645                 650                 655     


Leu Thr Ala Pro Leu Tyr Asn Thr Met Val Ile Ser Gln Pro Ala Ala 
            660                 665                 670         


Gly Ser Met Val Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Thr Gln 
        675                 680                 685             


Ser Ala Ala Val Thr Thr Phe Thr Gln Asp Arg Gln Ile Arg Phe Ser 
    690                 695                 700                 


Gln Gly Gln Gln Leu Val Thr Lys Leu Val Thr Ala Pro Val Ala Cys 
705                 710                 715                 720 


Gly Ala Val Met Val Pro Ser Thr Met Leu Met Gly Gln Val Val Thr 
                725                 730                 735     


Ala Tyr Pro Thr Phe Ala Thr Gln Gln Gln Gln Ser Gln Thr Leu Ser 
            740                 745                 750         


Val Thr Gln Gln Gln Gln Gln Gln Ser Ser Gln Glu Gln Gln Leu Thr 
        755                 760                 765             


Ser Val Gln Gln Pro Ser Gln Ala Gln Leu Thr Gln Pro Pro Gln Gln 
    770                 775                 780                 


Phe Leu Gln Thr Ser Arg Leu Leu His Gly Asn Pro Ser Thr Gln Leu 
785                 790                 795                 800 


Ile Leu Ser Ala Ala Phe Pro Leu Gln Gln Ser Thr Phe Pro Gln Ser 
                805                 810                 815     


His His Gln Gln His Gln Ser Gln Gln Gln Gln Gln Leu Ser Arg His 
            820                 825                 830         


Arg Thr Asp Ser Leu Pro Asp Pro Ser Lys Val Gln Pro Gln 
        835                 840                 845     


<210> 6650
<211> 605
<212> PRT
<213> Homo sapiens

<400> 6650
Met Val Leu Cys Pro Val Ile Gly Lys Leu Leu His Lys Arg Val Val 
1               5                   10                  15      


Leu Ala Ser Ala Ser Pro Arg Arg Gln Glu Ile Leu Ser Asn Ala Gly 
            20                  25                  30          


Leu Arg Phe Glu Val Val Pro Ser Lys Phe Lys Glu Lys Leu Asp Lys 
        35                  40                  45              


Ala Ser Phe Ala Thr Pro Tyr Gly Tyr Ala Met Glu Thr Ala Lys Gln 
    50                  55                  60                  


Lys Ala Leu Glu Val Ala Asn Arg Leu Tyr Gln Thr Val Gly Gly Leu 
65                  70                  75                  80  


Ile Leu Glu Lys Pro Val Asp Lys Gln Asp Ala Tyr Arg Met Leu Ser 
                85                  90                  95      


Arg Leu Ser Gly Arg Glu His Ser Val Phe Thr Gly Val Ala Ile Val 
            100                 105                 110         


His Cys Ser Ser Lys Asp His Gln Leu Asp Thr Arg Val Ser Glu Phe 
        115                 120                 125             


Tyr Glu Glu Thr Lys Val Lys Phe Ser Glu Leu Ser Glu Glu Leu Leu 
    130                 135                 140                 


Trp Glu Tyr Val His Ser Gly Glu Pro Met Asp Lys Ala Gly Gly Tyr 
145                 150                 155                 160 


Gly Ile Gln Ala Leu Gly Gly Met Leu Val Glu Ser Val His Gly Asp 
                165                 170                 175     


Phe Leu Asn Val Val Gly Phe Pro Leu Asn His Phe Cys Lys Gln Leu 
            180                 185                 190         


Val Lys Leu Tyr Tyr Pro Pro Arg Pro Glu Asp Leu Arg Arg Ser Val 
        195                 200                 205             


Lys His Asp Ser Ile Pro Ala Ala Asp Thr Phe Glu Asp Leu Ser Asp 
    210                 215                 220                 


Val Glu Gly Gly Gly Ser Glu Pro Thr Gln Arg Asp Ala Gly Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ala Glu Ala Gly Glu Ala Gly Gln Ala Thr Ala Glu Ala 
                245                 250                 255     


Glu Cys His Arg Thr Arg Glu Thr Leu Pro Pro Phe Pro Thr Arg Leu 
            260                 265                 270         


Leu Glu Leu Ile Glu Gly Phe Met Leu Ser Lys Gly Leu Leu Thr Ala 
        275                 280                 285             


Cys Lys Leu Lys Val Phe Asp Leu Leu Lys Asp Glu Ala Pro Gln Lys 
    290                 295                 300                 


Ala Ala Asp Ile Ala Ser Lys Val Asp Ala Ser Ala Cys Gly Met Glu 
305                 310                 315                 320 


Arg Leu Leu Asp Ile Cys Ala Ala Met Gly Leu Leu Glu Lys Thr Glu 
                325                 330                 335     


Gln Gly Tyr Ser Asn Thr Glu Thr Ala Asn Val Tyr Leu Ala Ser Asp 
            340                 345                 350         


Gly Glu Tyr Ser Leu His Gly Phe Ile Met His Asn Asn Asp Leu Thr 
        355                 360                 365             


Trp Asn Leu Phe Thr Tyr Leu Glu Phe Ala Ile Arg Glu Gly Thr Asn 
    370                 375                 380                 


Gln His His Arg Ala Leu Gly Lys Lys Ala Glu Asp Leu Phe Gln Asp 
385                 390                 395                 400 


Ala Tyr Tyr Gln Ser Pro Glu Thr Arg Leu Arg Phe Met Arg Ala Met 
                405                 410                 415     


His Gly Met Thr Lys Leu Thr Ala Cys Gln Val Ala Thr Ala Phe Asn 
            420                 425                 430         


Leu Ser Arg Phe Ser Ser Ala Cys Asp Val Gly Gly Cys Thr Gly Ala 
        435                 440                 445             


Leu Ala Arg Glu Leu Ala Arg Glu Tyr Pro Arg Met Gln Val Thr Val 
    450                 455                 460                 


Phe Asp Leu Pro Asp Ile Ile Glu Leu Ala Ala His Phe Gln Pro Pro 
465                 470                 475                 480 


Gly Pro Gln Ala Val Gln Ile His Phe Ala Ala Gly Asp Phe Phe Arg 
                485                 490                 495     


Asp Pro Leu Pro Ser Ala Glu Leu Tyr Val Leu Cys Arg Ile Leu His 
            500                 505                 510         


Asp Trp Pro Asp Asp Lys Val His Lys Leu Leu Ser Arg Val Ala Glu 
        515                 520                 525             


Ser Cys Lys Pro Gly Ala Gly Leu Leu Leu Val Glu Thr Leu Leu Asp 
    530                 535                 540                 


Glu Glu Lys Arg Val Ala Gln Arg Ala Leu Met Gln Ser Leu Asn Met 
545                 550                 555                 560 


Leu Val Gln Thr Glu Gly Lys Glu Arg Ser Leu Gly Glu Tyr Gln Cys 
                565                 570                 575     


Leu Leu Glu Leu His Gly Phe His Gln Val Gln Val Val His Leu Gly 
            580                 585                 590         


Gly Val Leu Asp Ala Ile Leu Ala Thr Lys Val Ala Pro 
        595                 600                 605 


<210> 6651
<211> 231
<212> PRT
<213> Homo sapiens

<400> 6651
Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
1               5                   10                  15      


Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
            20                  25                  30          


Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
        35                  40                  45              


Arg Lys Ile Lys Pro Lys Asn Ser Lys Gln Ala Glu Arg Glu Glu Lys 
    50                  55                  60                  


Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
65                  70                  75                  80  


Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                85                  90                  95      


Leu Ala Gly Ala Ala Gly Gly Pro Gly Ile Gly Arg Ala Ala Gly Arg 
            100                 105                 110         


Gly Ile Pro Ala Gly Val Pro Met Pro Gln Ala Pro Ala Gly Leu Ala 
        115                 120                 125             


Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
    130                 135                 140                 


Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser 
145                 150                 155                 160 


Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Gly Pro Pro 
                165                 170                 175     


Pro Pro Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly Pro Pro 
            180                 185                 190         


Pro Gly Met Arg Pro Pro Met Gly Pro Pro Met Gly Ile Pro Pro Gly 
        195                 200                 205             


Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
    210                 215                 220                 


Pro Gly Met Arg Gly Leu Leu 
225                 230     


<210> 6652
<211> 284
<212> PRT
<213> Homo sapiens

<400> 6652
Met Trp Arg Gly Leu Ala Leu Ala Arg Ala Ile Gly Cys Ala Ala Arg 
1               5                   10                  15      


Gly Arg Gly Gln Trp Ala Val Arg Ala Ala Asp Cys Ala Gln Ser Gly 
            20                  25                  30          


Arg His Pro Gly Pro Ala Val Val Cys Gly Arg Arg Leu Ile Ser Val 
        35                  40                  45              


Leu Glu Gln Ile Arg His Phe Val Met Met Pro Glu Ile Asn Thr Asn 
    50                  55                  60                  


His Leu Asp Lys Gln Gln Val Gln Leu Leu Ala Glu Met Cys Ile Leu 
65                  70                  75                  80  


Ile Asp Glu Asn Asp Asn Lys Ile Gly Ala Glu Thr Lys Lys Asn Cys 
                85                  90                  95      


His Leu Asn Glu Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe Ser 
            100                 105                 110         


Val Phe Leu Phe Asn Thr Glu Asn Lys Leu Leu Leu Gln Gln Arg Ser 
        115                 120                 125             


Asp Ala Lys Ile Thr Phe Pro Gly Cys Phe Thr Asn Thr Cys Cys Ser 
    130                 135                 140                 


His Pro Leu Ser Asn Pro Ala Glu Leu Glu Glu Ser Asp Ala Leu Gly 
145                 150                 155                 160 


Val Arg Arg Ala Ala Gln Arg Arg Leu Lys Ala Glu Leu Gly Ile Pro 
                165                 170                 175     


Leu Glu Glu Val Pro Pro Glu Glu Ile Asn Tyr Leu Thr Arg Ile His 
            180                 185                 190         


Tyr Lys Ala Gln Ser Asp Gly Ile Trp Gly Glu His Glu Ile Asp Tyr 
        195                 200                 205             


Ile Leu Leu Val Arg Lys Asn Val Thr Leu Asn Pro Asp Pro Asn Glu 
    210                 215                 220                 


Ile Lys Ser Tyr Cys Tyr Val Ser Lys Glu Glu Leu Lys Glu Leu Leu 
225                 230                 235                 240 


Lys Lys Ala Ala Ser Gly Glu Ile Lys Ile Thr Pro Trp Phe Lys Ile 
                245                 250                 255     


Ile Ala Ala Thr Phe Leu Phe Lys Trp Trp Asp Asn Leu Asn His Leu 
            260                 265                 270         


Asn Gln Phe Val Asp His Glu Lys Ile Tyr Arg Met 
        275                 280                 


<210> 6653
<211> 59
<212> PRT
<213> Homo sapiens

<400> 6653
Met Thr Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Gln Ser Asp Ser Val Lys Gly Lys Arg Arg Asp Asp Gly Leu Ser 
            20                  25                  30          


Ala Ala Ala Arg Lys Gln Arg Asp Ser Glu Ile Met Gln Gln Lys Gln 
        35                  40                  45              


Lys Lys Ala Asn Glu Lys Lys Glu Glu Pro Lys 
    50                  55                  


<210> 6654
<211> 1012
<212> PRT
<213> Homo sapiens

<400> 6654
Met Glu Glu Tyr Glu Lys Phe Cys Glu Lys Ser Leu Ala Arg Ile Gln 
1               5                   10                  15      


Glu Ala Ser Leu Ser Thr Glu Ser Phe Leu Pro Ala Gln Ser Glu Ser 
            20                  25                  30          


Ile Ser Leu Ile Arg Phe His Gly Val Ala Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ile Glu Lys Arg Lys Glu Met Gln Gln Glu Lys Gln Lys Ala Leu 
    50                  55                  60                  


Asp Val Glu Ala Arg Lys Gln Val Asn Arg Lys Lys Ala Leu Leu Thr 
65                  70                  75                  80  


Arg Val Gln Glu Ile Leu Asp Asn Val Gln Val Arg Lys Ala Pro Asn 
                85                  90                  95      


Ala Ser Asp Phe Asp Gln Trp Glu Met Glu Thr Val Tyr Ser Asn Ser 
            100                 105                 110         


Glu Val Arg Asn Leu Asn Val Pro Ala Thr Phe Pro Asn Ser Phe Pro 
        115                 120                 125             


Ser His Thr Glu His Ser Thr Ala Ala Lys Leu Asp Lys Ile Ala Gly 
    130                 135                 140                 


Ile Leu Pro Leu Asp Asn Glu Asp Gln Cys Lys Thr Asp Gly Ile Asp 
145                 150                 155                 160 


Leu Ala Arg Asp Ser Glu Gly Phe Asn Ser Pro Lys Gln Cys Asp Ser 
                165                 170                 175     


Ser Asn Ile Ser His Val Glu Asn Glu Ala Phe Pro Lys Thr Ser Ser 
            180                 185                 190         


Ala Thr Pro Gln Glu Thr Leu Ile Ser Asp Gly Pro Phe Ser Val Asn 
        195                 200                 205             


Glu Gln Gln Asp Leu Pro Leu Leu Ala Glu Val Ile Pro Asp Pro Tyr 
    210                 215                 220                 


Val Met Ser Leu Gln Asn Leu Met Lys Lys Ser Lys Glu Tyr Ile Glu 
225                 230                 235                 240 


Arg Glu Gln Ser Arg Arg Ser Leu Arg Gly Ser Ile Asn Arg Ile Val 
                245                 250                 255     


Asn Glu Ser His Leu Asp Lys Glu His Asp Ala Val Glu Val Ala Asp 
            260                 265                 270         


Cys Val Lys Glu Lys Gly Gln Leu Thr Gly Lys His Cys Val Ser Val 
        275                 280                 285             


Ile Pro Asp Lys Pro Ser Leu Asn Lys Ser Asn Val Leu Leu Gln Gly 
    290                 295                 300                 


Ala Ser Thr Gln Ala Ser Ser Met Ser Met Pro Val Leu Ala Ser Phe 
305                 310                 315                 320 


Ser Lys Val Asp Ile Pro Ile Arg Thr Gly His Pro Thr Val Leu Glu 
                325                 330                 335     


Ser Asn Ser Asp Phe Lys Val Ile Pro Thr Phe Val Thr Glu Asn Asn 
            340                 345                 350         


Val Ile Lys Ser Leu Thr Gly Ser Tyr Ala Lys Leu Pro Ser Pro Glu 
        355                 360                 365             


Pro Ser Met Ser Pro Lys Met His Arg Arg Arg Ser Arg Thr Ser Ser 
    370                 375                 380                 


Ala Cys His Ile Leu Ile Asn Asn Pro Ile Asn Ala Cys Glu Leu Ser 
385                 390                 395                 400 


Pro Lys Gly Lys Glu Gln Ala Met Asp Leu Ile Ile Gln Asp Thr Asp 
                405                 410                 415     


Glu Asn Thr Asn Val Pro Glu Ile Met Pro Lys Leu Pro Thr Asp Leu 
            420                 425                 430         


Ala Gly Val Cys Ser Ser Lys Val Tyr Val Gly Lys Asn Thr Ser Glu 
        435                 440                 445             


Val Lys Glu Asp Val Val Leu Gly Lys Ser Asn Gln Val Cys Gln Ser 
    450                 455                 460                 


Ser Gly Asn His Leu Glu Asn Lys Val Thr His Gly Leu Val Thr Val 
465                 470                 475                 480 


Glu Gly Gln Leu Thr Ser Asp Glu Arg Gly Ala His Ile Met Asn Ser 
                485                 490                 495     


Thr Cys Ala Ala Met Pro Lys Leu His Glu Pro Tyr Ala Ser Ser Gln 
            500                 505                 510         


Cys Ile Ala Ser Pro Asn Phe Gly Thr Val Ser Gly Leu Lys Pro Ala 
        515                 520                 525             


Ser Met Leu Glu Lys Asn Cys Ser Leu Gln Thr Glu Leu Asn Lys Ser 
    530                 535                 540                 


Tyr Asp Val Lys Asn Pro Ser Pro Leu Leu Met Gln Asn Gln Asn Thr 
545                 550                 555                 560 


Arg Gln Gln Met Asp Thr Pro Met Val Ser Cys Gly Asn Glu Gln Phe 
                565                 570                 575     


Leu Asp Asn Ser Phe Glu Lys Val Lys Arg Arg Leu Asp Leu Asp Ile 
            580                 585                 590         


Asp Gly Leu Gln Lys Glu Asn Cys Pro Tyr Val Ile Thr Ser Gly Ile 
        595                 600                 605             


Thr Glu Gln Glu Arg Gln His Leu Pro Glu Lys Arg Tyr Pro Lys Gly 
    610                 615                 620                 


Ser Gly Phe Val Asn Lys Asn Lys Met Leu Gly Thr Ser Ser Lys Glu 
625                 630                 635                 640 


Ser Glu Glu Leu Leu Lys Ser Lys Met Leu Ala Phe Glu Glu Met Arg 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln His Ala Gln Gln Leu Ser Leu Leu Ile Ala 
            660                 665                 670         


Glu Gln Glu Arg Glu Gln Glu Arg Leu Gln Lys Glu Ile Glu Glu Gln 
        675                 680                 685             


Glu Lys Met Leu Lys Glu Lys Lys Ala Met Thr Ala Glu Ala Ser Glu 
    690                 695                 700                 


Leu Asp Ile Asn Asn Ala Val Glu Leu Glu Trp Arg Lys Ile Ser Asp 
705                 710                 715                 720 


Ser Ser Leu Leu Glu Thr Met Leu Ser Gln Ala Asp Ser Leu His Thr 
                725                 730                 735     


Ser Asn Ser Asn Ser Ser Gly Phe Thr Asn Ser Ala Met Gln Tyr Ser 
            740                 745                 750         


Phe Val Ser Ala Asn Glu Ala Pro Phe Tyr Leu Trp Gly Ser Ser Thr 
        755                 760                 765             


Ser Gly Leu Thr Lys Leu Ser Val Thr Arg Pro Phe Gly Arg Ala Lys 
    770                 775                 780                 


Thr Arg Trp Ser Gln Val Phe Ser Leu Glu Ile Gln Ala Lys Phe Asn 
785                 790                 795                 800 


Lys Ile Thr Ala Val Ala Lys Gly Phe Leu Thr Arg Arg Leu Met Gln 
                805                 810                 815     


Thr Asp Lys Leu Lys Gln Leu Arg Gln Thr Val Lys Asp Thr Met Glu 
            820                 825                 830         


Phe Ile Arg Ser Phe Gln Ser Glu Ala Pro Leu Lys Arg Gly Ile Val 
        835                 840                 845             


Ser Ala Gln Asp Ala Ser Leu Gln Glu Arg Val Leu Ala Gln Leu Arg 
    850                 855                 860                 


Ala Ala Leu Tyr Gly Ile His Asp Ile Phe Phe Val Met Asp Ala Ala 
865                 870                 875                 880 


Glu Arg Met Ser Ile Leu His His Asp Arg Glu Val Arg Lys Glu Lys 
                885                 890                 895     


Met Leu Arg Gln Met Asp Lys Met Lys Ser Pro Arg Val Ala Leu Ser 
            900                 905                 910         


Ala Ala Thr Gln Lys Ser Leu Asp Arg Lys Lys Tyr Met Lys Ala Ala 
        915                 920                 925             


Glu Met Gly Met Pro Asn Lys Lys Phe Leu Val Lys Gln Asn Pro Ser 
    930                 935                 940                 


Glu Thr Arg Val Leu Gln Pro Asn Gln Gly Gln Asn Ala Pro Val His 
945                 950                 955                 960 


Arg Leu Leu Ser Arg Gln Gly Thr Pro Lys Thr Ser Val Lys Gly Val 
                965                 970                 975     


Val Gln Asn Arg Gln Lys Pro Ser Gln Ser Arg Val Pro Asn Arg Val 
            980                 985                 990         


Pro Val Ser Gly Val Tyr Ala Gly  Lys Ile Gln Arg Lys  Arg Pro Asn 
        995                 1000                 1005             


Val Ala  Thr Ile 
    1010         


<210> 6655
<211> 88
<212> PRT
<213> Homo sapiens

<400> 6655
Met Ala Ser Ala Ser Ala Arg Gly Asn Gln Asp Lys Asp Ala His Phe 
1               5                   10                  15      


Pro Pro Pro Ser Lys Gln Ser Leu Leu Phe Cys Pro Lys Ser Lys Leu 
            20                  25                  30          


His Ile His Arg Ala Glu Ile Ser Lys Ile Met Arg Glu Cys Gln Glu 
        35                  40                  45              


Glu Ser Phe Trp Lys Arg Ala Leu Pro Phe Ser Leu Val Ser Met Leu 
    50                  55                  60                  


Val Thr Gln Gly Leu Val Tyr Gln Gly Tyr Leu Ala Ala Asn Ser Arg 
65                  70                  75                  80  


Phe Gly Ser Leu Pro Lys Val Ala 
                85              


<210> 6656
<211> 245
<212> PRT
<213> Homo sapiens

<400> 6656
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 
            180                 185                 190         


Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 
        195                 200                 205             


Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 
    210                 215                 220                 


Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 
225                 230                 235                 240 


Asp Thr Trp Asp Glu 
                245 


<210> 6657
<211> 516
<212> PRT
<213> Homo sapiens

<400> 6657
Met Ser Tyr Pro Ala Asp Asp Tyr Glu Ser Glu Ala Ala Tyr Asp Pro 
1               5                   10                  15      


Tyr Ala Tyr Pro Ser Asp Tyr Asp Met His Thr Gly Asp Pro Lys Gln 
            20                  25                  30          


Asp Leu Ala Tyr Glu Arg Gln Tyr Glu Gln Gln Thr Tyr Gln Val Ile 
        35                  40                  45              


Pro Glu Val Ile Lys Asn Phe Ile Gln Tyr Phe His Lys Thr Val Ser 
    50                  55                  60                  


Asp Leu Ile Asp Gln Lys Val Tyr Glu Leu Gln Ala Ser Arg Val Ser 
65                  70                  75                  80  


Ser Asp Val Ile Asp Gln Lys Val Tyr Glu Ile Gln Asp Ile Tyr Glu 
                85                  90                  95      


Asn Ser Trp Thr Lys Leu Thr Glu Arg Phe Phe Lys Asn Thr Pro Trp 
            100                 105                 110         


Pro Glu Ala Glu Ala Ile Ala Pro Gln Val Gly Asn Asp Ala Val Phe 
        115                 120                 125             


Leu Ile Leu Tyr Lys Glu Leu Tyr Tyr Arg His Ile Tyr Ala Lys Val 
    130                 135                 140                 


Ser Phe Gln Ser Phe Ser Gln Tyr Arg Cys Lys Thr Ala Lys Lys Ser 
145                 150                 155                 160 


Glu Glu Glu Ile Asp Phe Leu Arg Ser Asn Pro Lys Ile Trp Asn Val 
                165                 170                 175     


His Ser Val Leu Asn Val Leu His Ser Leu Val Asp Lys Ser Asn Ile 
            180                 185                 190         


Asn Arg Gln Leu Glu Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val 
        195                 200                 205             


Ala Gly Glu Tyr Gly Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe 
    210                 215                 220                 


Ser Leu Val Gly Leu Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr 
225                 230                 235                 240 


Gln Ala Ile Lys Val Leu Glu Asn Ile Glu Leu Asn Lys Lys Ser Met 
                245                 250                 255     


Tyr Ser Arg Val Pro Glu Cys Gln Val Thr Thr Tyr Tyr Tyr Val Gly 
            260                 265                 270         


Phe Ala Tyr Leu Met Met Arg Arg Tyr Gln Asp Ala Ile Arg Val Phe 
        275                 280                 285             


Ala Asn Ile Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln Arg 
    290                 295                 300                 


Thr Thr Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met His 
305                 310                 315                 320 


Ala Leu Leu Ala Ile Ala Leu Thr Met Tyr Pro Met Arg Ile Asp Glu 
                325                 330                 335     


Ser Ile His Leu Gln Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg 
            340                 345                 350         


Met Gln Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr Ser 
        355                 360                 365             


Cys Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val His 
    370                 375                 380                 


Pro Asn Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe Ser 
385                 390                 395                 400 


Asp Glu Val Gln Gln Gln Ala Gln Leu Ser Thr Ile Arg Ser Phe Leu 
                405                 410                 415     


Lys Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp 
            420                 425                 430         


Leu Thr Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His Lys 
        435                 440                 445             


Met Lys Asn Leu Val Trp Thr Ser Gly Ile Ser Ala Leu Asp Gly Glu 
    450                 455                 460                 


Phe Gln Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met Ile 
465                 470                 475                 480 


His Ile Ala Asp Thr Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe Ile 
                485                 490                 495     


Arg Gln Ile His Lys Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met 
            500                 505                 510         


Gly Gln Arg Pro 
        515     


<210> 6658
<211> 833
<212> PRT
<213> Homo sapiens

<400> 6658
Leu Ser Arg Arg Val Pro Cys Val Arg Arg Gly Cys Arg Pro Pro Leu 
1               5                   10                  15      


Pro Pro Leu Pro Gly Ser Gln Ser Arg Ala Trp Ser Arg Asp Arg Glu 
            20                  25                  30          


Ala Pro Leu Asp Pro Gly Arg Pro Ala Gln Ser Gly Arg Arg Pro Thr 
        35                  40                  45              


Ser Arg Ser Val Ser His Ala Cys Ser Trp Asn Gly Gly Ser Leu Asp 
    50                  55                  60                  


Pro Leu Glu Gly Thr Pro Ala Leu Leu Arg Ser Ala Glu Arg Leu Met 
65                  70                  75                  80  


Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser Trp 
                85                  90                  95      


Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Ile Thr Ser Tyr 
            100                 105                 110         


Asp Phe His Ser Glu Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser 
        115                 120                 125             


Leu Phe His Cys Arg Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro 
    130                 135                 140                 


Met Lys Pro Leu Glu Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp 
145                 150                 155                 160 


Pro Lys Ile Cys Pro Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn 
                165                 170                 175     


Ser Asp Leu Trp Val Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu 
            180                 185                 190         


Thr Phe Cys His Gln Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser 
        195                 200                 205             


Ala Gly Val Ala Thr Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr 
    210                 215                 220                 


Gly Tyr Trp Trp Cys Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu 
225                 230                 235                 240 


Lys Thr Leu Arg Ile Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu 
                245                 250                 255     


Val Ile His Val Pro Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser 
            260                 265                 270         


Tyr Arg Tyr Pro Arg Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys 
        275                 280                 285             


Leu Ala Glu Phe Gln Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln 
    290                 295                 300                 


Glu Lys Glu Leu Val Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu 
305                 310                 315                 320 


Tyr Ile Ala Arg Ala Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala 
                325                 330                 335     


Met Phe Leu Asp Arg Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro 
            340                 345                 350         


Pro Ala Leu Phe Ile Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala 
        355                 360                 365             


Ser Ala Arg Ala Val Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu 
    370                 375                 380                 


Glu Val Thr Asn Val Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe 
385                 390                 395                 400 


Pro Gln Ser Glu Gly Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu 
                405                 410                 415     


Cys Lys Thr Gly Phe Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys 
            420                 425                 430         


Ser Gln Gly Tyr Asp Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu 
        435                 440                 445             


Phe Lys Cys Pro Ile Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp 
    450                 455                 460                 


Glu Val Leu Ala Arg His Gly Ser Lys Ile Trp Val Asn Glu Glu Thr 
465                 470                 475                 480 


Lys Leu Val Tyr Phe Gln Gly Thr Lys Asp Thr Pro Leu Glu His His 
                485                 490                 495     


Leu Tyr Val Val Ser Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr 
            500                 505                 510         


Thr Pro Gly Phe Ser His Ser Cys Ser Met Ser Gln Asn Phe Asp Met 
        515                 520                 525             


Phe Val Ser His Tyr Ser Ser Val Ser Thr Pro Pro Cys Val His Val 
    530                 535                 540                 


Tyr Lys Leu Ser Gly Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg 
545                 550                 555                 560 


Phe Trp Ala Ser Met Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val 
                565                 570                 575     


Pro Pro Glu Ile Phe His Phe His Thr Arg Ser Asp Val Arg Leu Tyr 
            580                 585                 590         


Gly Met Ile Tyr Lys Pro His Ala Leu Gln Pro Gly Lys Lys His Pro 
        595                 600                 605             


Thr Val Leu Phe Val Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn 
    610                 615                 620                 


Ser Phe Lys Gly Ile Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu 
625                 630                 635                 640 


Gly Tyr Ala Val Val Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly 
                645                 650                 655     


Leu Arg Phe Glu Gly Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile 
            660                 665                 670         


Glu Asp Gln Val Glu Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe 
        675                 680                 685             


Ile Asp Leu Ser Arg Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe 
    690                 695                 700                 


Leu Ser Leu Met Gly Leu Ile His Lys Pro Gln Val Phe Lys Val Ala 
705                 710                 715                 720 


Ile Ala Gly Ala Pro Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr 
                725                 730                 735     


Thr Glu Arg Tyr Met Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu 
            740                 745                 750         


Ala Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn 
        755                 760                 765             


Arg Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe 
    770                 775                 780                 


His Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr 
785                 790                 795                 800 


Gln Leu Gln Ile Tyr Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu 
                805                 810                 815     


Ser Gly Glu His Tyr Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr 
            820                 825                 830         


Leu 
    


<210> 6659
<211> 1690
<212> PRT
<213> Homo sapiens

<400> 6659
Met Asp Cys Leu Leu Glu Leu Ser Ala Thr Asp Thr Lys Ile Glu Glu 
1               5                   10                  15      


Ser Ser Ser Gln Ser Phe Val Ala Ser Glu Asn Gln Val Gly Ala Ala 
            20                  25                  30          


Glu Ser Lys Ile Met Glu Lys Arg Pro Glu Glu Glu Ser Glu Asp Ser 
        35                  40                  45              


Lys Met Asp Ser Phe Leu Asp Met Gln Leu Thr Glu Asp Leu Asp Ser 
    50                  55                  60                  


Leu Ile Gln Asn Ala Phe Glu Lys Leu Asn Ser Ser Pro Asp Asp Gln 
65                  70                  75                  80  


Val Tyr Ser Phe Leu Pro Ser Gln Asp Val Asn Ser Phe Asn Asp Ser 
                85                  90                  95      


Ser Glu Phe Ile Asn Pro Asp Ser Ser Asn Met Thr Pro Ile Phe Ser 
            100                 105                 110         


Thr Gln Asn Met Asn Leu Asn Gly Glu Asn Leu Glu Asn Ser Gly Ser 
        115                 120                 125             


Thr Leu Ser Leu Asn Pro Leu Pro Ser His Ser Val Leu Asn Glu Ser 
    130                 135                 140                 


Lys Cys Phe Ile Lys Asp Asn Thr Leu Ala Leu Glu Ser Asn Tyr Pro 
145                 150                 155                 160 


Glu Asp Ser Leu Leu Ser Ser Ser Leu Asn Val Ala Ser Asp Ser Ile 
                165                 170                 175     


Ala Gly Cys Ser Ser Leu Asn Gln Lys Gln Lys Glu Leu Leu Glu Ser 
            180                 185                 190         


Glu Cys Val Glu Ala Gln Phe Ser Glu Ala Pro Val Asp Leu Asp Ala 
        195                 200                 205             


Ser Glu Pro Gln Ala Cys Leu Asn Leu Pro Gly Leu Asp Leu Pro Gly 
    210                 215                 220                 


Thr Gly Gly Asp Gln Lys Ser Thr Arg Val Ser Asp Val Phe Leu Pro 
225                 230                 235                 240 


Ser Glu Gly Phe Asn Phe Lys Pro His Lys His Pro Glu Leu Pro Thr 
                245                 250                 255     


Lys Gly Lys Asp Val Ser Tyr Cys Pro Val Leu Ala Pro Leu Pro Leu 
            260                 265                 270         


Leu Leu Pro Pro Pro Pro Pro Pro Pro Met Trp Asn Pro Met Ile Pro 
        275                 280                 285             


Ala Phe Asp Leu Phe Gln Gly Asn His Gly Phe Val Ala Pro Val Val 
    290                 295                 300                 


Thr Thr Ala Ala His Trp Arg Ser Val Asn Tyr Thr Phe Pro Pro Ser 
305                 310                 315                 320 


Val Ile Ser His Thr Ser Pro Thr Lys Val Trp Arg Asn Lys Asp Gly 
                325                 330                 335     


Thr Ser Ala Tyr Gln Val Gln Glu Thr Pro Val Ser Gln Val Val Arg 
            340                 345                 350         


Lys Lys Thr Ser Tyr Val Gly Leu Val Leu Val Leu Leu Arg Gly Leu 
        355                 360                 365             


Pro Gly Ser Gly Lys Ser Phe Leu Ala Arg Thr Leu Gln Glu Asp Asn 
    370                 375                 380                 


Pro Ser Gly Val Ile Leu Ser Thr Asp Asp Tyr Phe Tyr Ile Asn Gly 
385                 390                 395                 400 


Gln Tyr Gln Phe Asp Val Lys Tyr Leu Gly Glu Ala His Glu Trp Asn 
                405                 410                 415     


Gln Asn Arg Ala Lys Glu Ala Phe Glu Lys Lys Ile Ser Pro Ile Ile 
            420                 425                 430         


Ile Asp Asn Thr Asn Leu Gln Ala Trp Glu Met Lys Pro Tyr Val Ala 
        435                 440                 445             


Leu Ser Gln Lys His Lys Tyr Lys Val Leu Phe Arg Glu Pro Asp Thr 
    450                 455                 460                 


Trp Trp Lys Phe Lys Pro Lys Glu Leu Ala Arg Arg Asn Ile His Gly 
465                 470                 475                 480 


Val Ser Lys Glu Lys Ile Thr Arg Met Leu Glu His Tyr Gln Arg Phe 
                485                 490                 495     


Val Ser Val Pro Ile Ile Met Ser Ser Ser Val Pro Glu Lys Ile Glu 
            500                 505                 510         


Arg Ile Glu Leu Cys Ala Tyr Ser Cys Glu Asp Arg Ser Thr Ser Pro 
        515                 520                 525             


Arg Asp Asp Glu Asp Ile Ile Ser Glu Lys Glu Glu Asn Ile Leu Ser 
    530                 535                 540                 


Leu Ser Leu Lys His Leu Glu Phe Thr Glu Glu Lys Asn Leu Asp Val 
545                 550                 555                 560 


Thr Lys Glu Thr Met Leu Pro Glu Asn Val Ala Tyr Leu Ser Asn Ala 
                565                 570                 575     


Asp Leu Asn Lys Arg Arg Lys Glu Ile Ser Asp Met Asn Pro Ser Ile 
            580                 585                 590         


Gln Ser Ala Leu Ile Leu Glu Thr Pro His Met Tyr Phe Ser Asp Ser 
        595                 600                 605             


Glu Ser Lys Leu Gln Ala Thr Asp Lys Ser Glu Asn Glu Gln Ile Glu 
    610                 615                 620                 


Met Val Ala Val Lys Gly Tyr Ser Lys Thr Asp Thr Asp Ser Ser Met 
625                 630                 635                 640 


Glu Arg Val Ser Pro Ser Thr Cys Cys Ser Glu Asn Asn Gln Glu Asp 
                645                 650                 655     


Cys Asp Leu Ala Asn Ser Gly Pro Leu Gln Asn Glu Lys Ser Ser Pro 
            660                 665                 670         


Gly Glu Ile Val Glu Glu Arg Ala Thr Val Thr Lys Lys Ala Phe Gly 
        675                 680                 685             


Lys Gln Lys Ser Lys Ser Thr Leu Glu Lys Phe Pro Arg His Glu Leu 
    690                 695                 700                 


Ser Asn Phe Val Gly Asp Trp Pro Val Asp Lys Thr Ile Gly Gln Arg 
705                 710                 715                 720 


Thr Lys Arg Asn Arg Lys Thr Glu Lys Thr Ser Ser Val Gln Ser Asp 
                725                 730                 735     


Lys Lys Tyr Asn Tyr Pro Gln Ser His Lys Leu Val Asn Ser Val Ser 
            740                 745                 750         


Val Asn Thr Asp Cys Val Gln Gln Arg Gly Ser Pro His Glu Ser Val 
        755                 760                 765             


Glu Asp Gly Arg Lys Ser Gln Cys Asp Asp Ala Ser Glu Pro Leu Asn 
    770                 775                 780                 


Ser Tyr Lys Tyr Asp Ala Tyr Lys Asn Ile Asp Lys Asn Ser Phe Asn 
785                 790                 795                 800 


Ile Met Gly Asp Trp Pro Ser Ser Asp Ser Leu Ala Gln Arg Glu His 
                805                 810                 815     


Arg Ser Arg Met Pro Lys Thr Gly Leu Ser Glu Pro Asn Leu Glu Ile 
            820                 825                 830         


Gly Thr Asn Asp Lys Met Asn Glu Ile Ser Leu Ser Thr Ala His Glu 
        835                 840                 845             


Ala Cys Trp Gly Thr Ser Ser Gln Lys Leu Lys Thr Leu Gly Ser Ser 
    850                 855                 860                 


Asn Leu Gly Ser Ser Glu Met Leu Leu Ser Glu Met Thr Cys Glu Ser 
865                 870                 875                 880 


Gln Thr Cys Leu Ser Lys Lys Ser His Gly Gln His Thr Ser Leu Pro 
                885                 890                 895     


Leu Thr Phe Thr Asn Ser Ala Pro Thr Val Ser Gly Val Val Glu Pro 
            900                 905                 910         


Gln Thr Leu Ala Glu Cys Gln Glu Gln Met Pro Lys Arg Asp Pro Gly 
        915                 920                 925             


Lys Glu Val Gly Met Cys Thr Gln Thr Glu Pro Gln Asp Phe Ala Leu 
    930                 935                 940                 


Leu Trp Lys Ile Glu Lys Asn Lys Ile Ser Ile Ser Asp Ser Ile Lys 
945                 950                 955                 960 


Val Leu Thr Gly Arg Leu Asp Gly Phe Lys Pro Lys Val Phe Asn Ile 
                965                 970                 975     


Asn Thr Lys Ser Asp Val Gln Glu Ala Ile Pro Tyr Arg Val Met Tyr 
            980                 985                 990         


Asp Lys Ser Thr Phe Val Glu Glu  Ser Glu Leu Thr Ser  Ala Asp Glu 
        995                 1000                 1005             


Ser Glu  Asn Leu Asn Ile Leu  Cys Lys Leu Phe Gly  Ser Phe Ser 
    1010                 1015                 1020             


Leu Glu  Ala Leu Lys Asp Leu  Tyr Glu Arg Cys Asn  Lys Asp Ile 
    1025                 1030                 1035             


Ile Trp  Ala Thr Ser Leu Leu  Leu Asp Ser Glu Thr  Lys Leu Cys 
    1040                 1045                 1050             


Glu Asp  Thr Glu Phe Glu Asn  Phe Gln Lys Ser Cys  Asp Gly Ser 
    1055                 1060                 1065             


Gln Ile  Gly Pro Phe Ser Leu  Gly Leu Asn Leu Lys  Glu Ile Ile 
    1070                 1075                 1080             


Ser Gln  Arg Gly Thr Leu Glu  Asn Ser Asn Ser Pro  Val Pro Glu 
    1085                 1090                 1095             


Phe Ser  His Gly Ile Gly Ile  Ser Asn Ala Asp Ser  Gln Ser Thr 
    1100                 1105                 1110             


Cys Asp  Ala Glu Arg Gly Asn  Ser Glu Gln Ala Glu  Met Arg Ala 
    1115                 1120                 1125             


Val Thr  Pro Glu Asn His Glu  Ser Met Thr Ser Ile  Phe Pro Ser 
    1130                 1135                 1140             


Ala Ala  Val Gly Leu Lys Asn  Asn Asn Asp Ile Leu  Pro Asn Ser 
    1145                 1150                 1155             


Gln Glu  Glu Leu Leu Tyr Ser  Ser Lys Gln Ser Phe  Pro Gly Ile 
    1160                 1165                 1170             


Leu Lys  Ala Thr Thr Pro Lys  Asp Met Ser Glu Thr  Glu Lys Asn 
    1175                 1180                 1185             


Leu Val  Val Thr Glu Thr Gly  Asp Asn Ile His Ser  Pro Ser His 
    1190                 1195                 1200             


Phe Ser  Asp Ile Phe Asn Phe  Val Ser Ser Thr Ser  Asn Leu Glu 
    1205                 1210                 1215             


Leu Asn  Glu Glu Ile Tyr Phe  Thr Asp Ser Leu Glu  Ile Lys Arg 
    1220                 1225                 1230             


Asn Glu  Asn Phe Pro Lys Asp  Tyr Val Lys Phe Ser  Asp Glu Glu 
    1235                 1240                 1245             


Glu Phe  Met Asn Glu Asp Glu  Lys Glu Met Lys Glu  Ile Leu Met 
    1250                 1255                 1260             


Ala Gly  Ser Ser Leu Ser Ala  Gly Val Ser Gly Glu  Asp Lys Thr 
    1265                 1270                 1275             


Glu Ile  Leu Asn Pro Thr Pro  Ala Met Ala Lys Ser  Leu Thr Ile 
    1280                 1285                 1290             


Asp Cys  Leu Glu Leu Ala Leu  Pro Pro Glu Leu Ala  Phe Gln Leu 
    1295                 1300                 1305             


Asn Glu  Leu Phe Gly Pro Val  Gly Ile Asp Ser Gly  Ser Leu Thr 
    1310                 1315                 1320             


Val Glu  Asp Cys Val Val His  Ile Asp Leu Asn Leu  Ala Lys Val 
    1325                 1330                 1335             


Ile His  Glu Lys Trp Lys Glu  Ser Val Met Glu Arg  Gln Arg Gln 
    1340                 1345                 1350             


Glu Glu  Val Ser Cys Gly Lys  Phe Met Gln Asp Pro  Ser Leu Val 
    1355                 1360                 1365             


Gly His  Thr Gly Leu Asp Asn  Pro Glu Gln Lys Ser  Ser Gln Arg 
    1370                 1375                 1380             


Thr Gly  Lys Lys Leu Leu Lys  Thr Leu Thr Ala Ser  Glu Met Leu 
    1385                 1390                 1395             


Pro Leu  Leu Asp His Trp Asn  Thr Gln Thr Lys Lys  Val Ser Leu 
    1400                 1405                 1410             


Arg Glu  Ile Met Ser Glu Glu  Ile Ala Leu Gln Glu  Lys His Asn 
    1415                 1420                 1425             


Leu Lys  Arg Glu Thr Leu Met  Phe Glu Lys Asp Cys  Ala Thr Lys 
    1430                 1435                 1440             


Leu Lys  Glu Lys Gln Leu Phe  Lys Ile Phe Pro Ala  Ile Asn Gln 
    1445                 1450                 1455             


Asn Phe  Leu Val Asp Ile Phe  Lys Asp His Asn Tyr  Ser Leu Glu 
    1460                 1465                 1470             


His Thr  Val Gln Phe Leu Asn  Cys Val Leu Glu Gly  Asp Pro Val 
    1475                 1480                 1485             


Lys Thr  Val Val Ala Gln Glu  Phe Val His Gln Asn  Glu Asn Val 
    1490                 1495                 1500             


Thr Ser  His Thr Gly Gln Lys  Ser Lys Glu Lys Lys  Pro Lys Lys 
    1505                 1510                 1515             


Leu Lys  Glu Thr Glu Glu Thr  Pro Ser Glu Leu Ser  Phe Gln Asp 
    1520                 1525                 1530             


Phe Glu  Tyr Pro Asp Tyr Asp  Asp Tyr Arg Ala Glu  Ala Phe Leu 
    1535                 1540                 1545             


His Gln  Gln Lys Arg Met Glu  Cys Tyr Ser Lys Ala  Lys Glu Ala 
    1550                 1555                 1560             


Tyr Arg  Ile Gly Lys Lys Asn  Val Ala Thr Phe Tyr  Ala Gln Gln 
    1565                 1570                 1575             


Gly Thr  Leu His Glu Gln Lys  Met Lys Glu Ala Asn  His Leu Ala 
    1580                 1585                 1590             


Ala Ile  Glu Ile Phe Glu Lys  Val Asn Ala Ser Leu  Leu Pro Gln 
    1595                 1600                 1605             


Asn Val  Leu Asp Leu His Gly  Leu His Val Asp Glu  Ala Leu Glu 
    1610                 1615                 1620             


His Leu  Met Arg Val Leu Glu  Lys Lys Thr Glu Glu  Phe Lys Gln 
    1625                 1630                 1635             


Asn Gly  Gly Lys Pro Tyr Leu  Ser Val Ile Thr Gly  Arg Gly Asn 
    1640                 1645                 1650             


His Ser  Gln Gly Gly Val Ala  Arg Ile Lys Pro Ala  Val Ile Lys 
    1655                 1660                 1665             


Tyr Leu  Ile Ser His Ser Phe  Arg Phe Ser Glu Ile  Lys Pro Gly 
    1670                 1675                 1680             


Cys Leu  Lys Val Met Leu Lys  
    1685                 1690 


<210> 6660
<211> 158
<212> PRT
<213> Homo sapiens

<400> 6660
Met Gly Ser Gly Ser Ser Arg Ser Ser Arg Thr Leu Arg Arg Arg Arg 
1               5                   10                  15      


Ser Pro Glu Ser Leu Pro Ala Gly Pro Gly Ala Ala Ala Leu Glu Gly 
            20                  25                  30          


Gly Thr Arg Arg Arg Val Pro Val Ala Ala Ala Glu Val Pro Gly Ala 
        35                  40                  45              


Ala Ala Glu Glu Ala Pro Gly Arg Asp Pro Ser Pro Val Ala Pro Pro 
    50                  55                  60                  


Asp Gly Arg Asp Glu Thr Leu Arg Leu Leu Asp Glu Leu Leu Ala Glu 
65                  70                  75                  80  


Ser Ala Ala Trp Gly Pro Pro Glu Pro Ala Pro Arg Arg Pro Ala Arg 
                85                  90                  95      


Leu Arg Pro Thr Ala Val Ala Gly Ser Ala Val Cys Ala Glu Gln Ser 
            100                 105                 110         


Thr Glu Gly His Pro Gly Ser Gly Asn Val Ser Glu Ala Pro Gly Ser 
        115                 120                 125             


Gly Arg Lys Lys Pro Glu Arg Pro Ala Ala Ile Ser Tyr Asp His Ser 
    130                 135                 140                 


Glu Glu Gly Leu Met Ala Ser Ile Glu Arg Glu Tyr Cys Arg 
145                 150                 155             


<210> 6661
<211> 245
<212> PRT
<213> Homo sapiens

<400> 6661
Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
65                  70                  75                  80  


Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                85                  90                  95      


Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Asp Asn 
    130                 135                 140                 


Ser Gln Gly Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu 
        195                 200                 205             


Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala 
225                 230                 235                 240 


Glu Gly Ala Glu Asn 
                245 


<210> 6662
<211> 337
<212> PRT
<213> Homo sapiens

<400> 6662
Met Glu Gln Pro Trp Pro Pro Pro Gly Pro Trp Ser Leu Pro Arg Ala 
1               5                   10                  15      


Glu Gly Glu Ala Glu Glu Glu Ser Asp Phe Asp Val Phe Pro Ser Ser 
            20                  25                  30          


Pro Arg Cys Pro Gln Leu Pro Gly Gly Gly Ala Gln Met Tyr Ser His 
        35                  40                  45              


Gly Ile Glu Leu Ala Cys Gln Lys Gln Lys Glu Phe Val Lys Ser Ser 
    50                  55                  60                  


Val Ala Cys Lys Trp Asn Leu Ala Glu Ala Gln Gln Lys Leu Gly Ser 
65                  70                  75                  80  


Leu Ala Leu His Asn Ser Glu Ser Leu Asp Gln Glu His Ala Lys Ala 
                85                  90                  95      


Gln Thr Ala Val Ser Glu Leu Arg Gln Arg Glu Glu Glu Trp Arg Gln 
            100                 105                 110         


Lys Glu Glu Ala Leu Val Gln Arg Glu Lys Met Cys Leu Trp Ser Thr 
        115                 120                 125             


Asp Ala Ile Ser Lys Asp Val Phe Asn Lys Ser Phe Ile Asn Gln Asp 
    130                 135                 140                 


Lys Arg Lys Asp Thr Glu Asp Glu Asp Lys Ser Glu Ser Phe Met Gln 
145                 150                 155                 160 


Lys Tyr Glu Gln Lys Ile Arg His Phe Gly Met Leu Ser Arg Trp Asp 
                165                 170                 175     


Asp Ser Gln Arg Phe Leu Ser Asp His Pro Tyr Leu Val Cys Glu Glu 
            180                 185                 190         


Thr Ala Lys Tyr Leu Ile Leu Trp Cys Phe His Leu Glu Ala Glu Lys 
        195                 200                 205             


Lys Gly Ala Leu Met Glu Gln Ile Ala His Gln Ala Val Val Met Gln 
    210                 215                 220                 


Phe Ile Met Glu Met Ala Lys Asn Cys Asn Val Asp Pro Arg Gly Cys 
225                 230                 235                 240 


Phe Arg Leu Phe Phe Gln Lys Ala Lys Ala Glu Glu Glu Gly Tyr Phe 
                245                 250                 255     


Glu Ala Phe Lys Asn Glu Leu Glu Ala Phe Lys Ser Arg Val Arg Leu 
            260                 265                 270         


Tyr Ser Gln Ser Gln Ser Phe Gln Pro Met Thr Val Gln Asn His Val 
        275                 280                 285             


Pro His Ser Gly Val Gly Ser Ile Gly Leu Leu Glu Ser Leu Pro Gln 
    290                 295                 300                 


Asn Pro Asp Tyr Leu Gln Tyr Ser Ile Ser Thr Ala Leu Cys Ser Leu 
305                 310                 315                 320 


Asn Ser Val Val His Lys Glu Asp Asp Glu Pro Lys Met Met Asp Thr 
                325                 330                 335     


Val 
    


<210> 6663
<211> 308
<212> PRT
<213> Homo sapiens

<400> 6663
Met Glu Gln Pro Trp Pro Pro Pro Gly Pro Trp Ser Leu Pro Arg Ala 
1               5                   10                  15      


Glu Gly Glu Ala Glu Glu Glu Ser Asp Phe Asp Val Phe Pro Ser Ser 
            20                  25                  30          


Pro Arg Cys Pro Gln Leu Pro Gly Gly Gly Ala Gln Met Tyr Ser His 
        35                  40                  45              


Gly Ile Glu Leu Ala Cys Gln Lys Gln Lys Glu Phe Val Lys Ser Ser 
    50                  55                  60                  


Val Ala Cys Lys Trp Asn Leu Ala Glu Ala Gln Gln Lys Leu Gly Ser 
65                  70                  75                  80  


Leu Ala Leu His Asn Ser Glu Ser Leu Asp Gln Glu His Ala Lys Ala 
                85                  90                  95      


Gln Thr Ala Val Ser Glu Leu Arg Gln Arg Glu Glu Glu Trp Arg Gln 
            100                 105                 110         


Lys Glu Glu Ala Leu Val Gln Arg Glu Lys Met Cys Leu Trp Ser Thr 
        115                 120                 125             


Asp Ala Ile Ser Lys Asp Val Phe Asn Lys Ser Phe Ile Asn Gln Asp 
    130                 135                 140                 


Lys Arg Lys Asp Thr Glu Asp Glu Asp Lys Ser Glu Ser Phe Met Gln 
145                 150                 155                 160 


Lys Tyr Glu Gln Lys Ile Arg His Phe Gly Met Leu Ser Arg Trp Asp 
                165                 170                 175     


Asp Ser Gln Arg Phe Leu Ser Asp His Pro Tyr Leu Val Cys Glu Glu 
            180                 185                 190         


Thr Ala Lys Tyr Leu Ile Leu Trp Cys Phe His Leu Glu Ala Glu Lys 
        195                 200                 205             


Lys Gly Ala Leu Met Glu Gln Ile Ala His Gln Ala Val Val Met Gln 
    210                 215                 220                 


Phe Ile Met Glu Met Ala Lys Asn Cys Asn Val Asp Pro Arg Gly Cys 
225                 230                 235                 240 


Phe Arg Leu Phe Phe Gln Lys Ala Lys Ala Glu Glu Glu Gly Tyr Phe 
                245                 250                 255     


Glu Ala Phe Lys Asn Glu Leu Glu Ala Phe Lys Ser Arg Val Arg Leu 
            260                 265                 270         


Tyr Ser Gln Ser Gln Ser Phe Gln Pro Met Thr Val Gln Asn His Val 
        275                 280                 285             


Pro His Ser Gly Val Gly Ser Ile Gly Leu Leu Glu Ser Leu Pro Gln 
    290                 295                 300                 


Ala Pro Arg Phe 
305             


<210> 6664
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 6664
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His Val Arg Thr Arg 
            820                 825                 830         


Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser Val Phe 
        835                 840                 845             


Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala Gln Trp Gln Arg 
    850                 855                 860                 


Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn Tyr Met Thr Gln 
865                 870                 875                 880 


Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp Pro Leu Ser Glu 
                885                 890                 895     


Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Val Lys Gly Val 
            900                 905                 910         


Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe Arg Pro Ala Ser 
        915                 920                 925             


Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser Met Glu Asn Leu 
    930                 935                 940                 


Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala Leu Gln Thr Ser 
945                 950                 955                 960 


Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg Ser Pro Leu Ile 
                965                 970                 975     


Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser Glu Thr Ser Ser 
            980                 985                 990         


Ser Arg Pro Gly Gly Tyr Arg Leu  Phe Ser Ser Ser Arg  Pro Pro Thr 
        995                 1000                 1005             


Glu Met  Lys Gln Ser Gly Leu  Gly Ser Gln Cys Thr  Gly Leu Phe 
    1010                 1015                 1020             


Ser Thr  Thr Val Leu Gly Gly  Ser Ser Ser Ala Pro  Asn Leu Gln 
    1025                 1030                 1035             


Asp Tyr  Ala Arg Ser His Gly  Lys Lys Leu Pro Pro  Ala Ser Leu 
    1040                 1045                 1050             


Lys His  Arg Asp Gly Phe Glu  Gly Cys Ser Met Val  Pro Thr Ile 
    1055                 1060                 1065             


Tyr Pro  Leu Glu Thr Leu His  Asn Ala Leu Ser Leu  Arg Gln Val 
    1070                 1075                 1080             


Ser Glu  Phe Leu Ser Arg Val  Cys Gln Arg His Thr  Asp Ala Gln 
    1085                 1090                 1095             


Ala Gln  Ala Ser Ala Ala Leu  Phe Asp Ser Met His  Ser Ser Gln 
    1100                 1105                 1110             


Ala Ser  Asp Asn Pro Phe Ser  Pro Pro Arg Thr Leu  His Ser Pro 
    1115                 1120                 1125             


Pro Leu  Gln Leu Gln Gln Arg  Ser Glu Lys Pro Pro  Trp Tyr Ser 
    1130                 1135                 1140             


Ser Gly  Pro Ser Ser Thr Val  Ser Ser Ala Gly Pro  Ser Ser Pro 
    1145                 1150                 1155             


Thr Thr  Val Asp Gly Asn Ser  Gln Phe Gly Phe Ser  Asp Gln Pro 
    1160                 1165                 1170             


Ser Leu  Asn Ser His Val Ala  Glu Glu His Gln Gly  Leu Gly Leu 
    1175                 1180                 1185             


Leu Gln  Glu Thr Pro Gly Ser  Gly Ala Gln Glu Leu  Ser Ile Glu 
    1190                 1195                 1200             


Gly Glu  Gln Glu Leu Phe Glu  Pro Asn Gln Ser Pro  Gln Val Pro 
    1205                 1210                 1215             


Pro Met  Glu Thr Ser Gln Pro  Tyr Glu Glu Val Ser  Gln Pro Cys 
    1220                 1225                 1230             


Gln Glu  Val Pro Asp Ile Ser  Gln Pro Cys Gln Asp  Ile Ser Glu 
    1235                 1240                 1245             


Ala Leu  Ser Gln Pro Cys Gln  Lys Val Pro Asp Ile  Ser Gln Gln 
    1250                 1255                 1260             


Cys Gln  Glu Asn His Asp Asn  Gly Asn His Thr Cys  Gln Glu Val 
    1265                 1270                 1275             


Pro His  Ile Ser Gln Pro Cys  Gln Lys Ser Ser Gln  Leu Cys Gln 
    1280                 1285                 1290             


Lys Val  Ser Glu Glu Val Cys  Gln Leu Cys Leu Glu  Asn Ser Glu 
    1295                 1300                 1305             


Glu Val  Ser Gln Pro Cys Gln  Gly Val Ser Val Glu  Val Gly Lys 
    1310                 1315                 1320             


Leu Val  His Lys Phe His Val  Gly Val Gly Ser Leu  Val Gln Glu 
    1325                 1330                 1335             


Thr Leu  Val Glu Val Gly Ser  Pro Ala Glu Glu Ile  Pro Glu Glu 
    1340                 1345                 1350             


Val Ile  Gln Pro Tyr Gln Glu  Phe Ser Val Glu Val  Gly Arg Leu 
    1355                 1360                 1365             


Ala Gln  Glu Thr Ser Ala Ile  Asn Leu Leu Ser Gln  Gly Ile Pro 
    1370                 1375                 1380             


Glu Ile  Asp Lys Pro Ser Gln  Glu Phe Pro Glu Glu  Ile Asp Leu 
    1385                 1390                 1395             


Gln Ala  Gln Glu Val Pro Glu  Glu Ile Asn 
    1400                 1405             


<210> 6665
<211> 175
<212> PRT
<213> Homo sapiens

<400> 6665
Met Ile Leu Asn Val Leu Glu Tyr Gly Ser Gln Gln Val Ala Asp Leu 
1               5                   10                  15      


Thr Leu Asn Leu Asp Asp Tyr Ile Asp Ala Glu His Leu Gly Asp Phe 
            20                  25                  30          


His Arg Thr Tyr Lys Asn Ser Glu Glu Leu Arg Ser Arg Ile Val Ser 
        35                  40                  45              


Gly Ile Ile Thr Pro Ile His Glu Gln Trp Glu Lys Ala Asn Val Ser 
    50                  55                  60                  


Ser Pro His Arg Glu Phe Pro Pro Ala Thr Ala Arg Glu Val Asp Pro 
65                  70                  75                  80  


Leu Arg Ile Pro Pro His His Pro His Thr Ser Arg Gln Pro Pro Trp 
                85                  90                  95      


Cys Asp Pro Leu Gly Pro Phe Val Val Gly Gly Glu Asp Leu Asp Pro 
            100                 105                 110         


Phe Gly Pro Arg Arg Gly Gly Met Ile Val Asp Pro Leu Arg Ser Gly 
        115                 120                 125             


Phe Pro Arg Ala Leu Ile Asp Pro Ser Ser Gly Leu Pro Asn Arg Leu 
    130                 135                 140                 


Pro Pro Gly Ala Val Pro Pro Gly Ala Arg Phe Asp Pro Phe Gly Pro 
145                 150                 155                 160 


Ile Gly Thr Ser Pro Pro Gly Pro Arg Pro Asp Arg Arg Gly Gln 
                165                 170                 175 


<210> 6666
<211> 183
<212> PRT
<213> Homo sapiens

<400> 6666
Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Phe Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Glu Tyr 
                85                  90                  95      


Gly Ser Gln Gln Val Ala Asp Leu Thr Leu Asn Leu Asp Asp Tyr Ile 
            100                 105                 110         


Asp Ala Glu His Leu Gly Asp Phe His Arg Thr Tyr Lys Asn Ser Glu 
        115                 120                 125             


Glu Leu Arg Ser Arg Ile Val Ser Gly Ile Ile Thr Pro Ile His Glu 
    130                 135                 140                 


Gln Trp Glu Lys Ala Asn Val Ser Ser Pro His Arg Glu Phe Pro Pro 
145                 150                 155                 160 


Ala Thr Ala Arg Glu Val Asp Pro Leu Arg Ile Pro Pro His His Pro 
                165                 170                 175     


His Thr Ser Arg Gln Pro Pro 
            180             


<210> 6667
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6667
Met Pro Val His Thr Leu Ser Pro Gly Ala Pro Ser Ala Pro Ala Leu 
1               5                   10                  15      


Pro Cys Arg Leu Arg Thr Arg Val Pro Gly Tyr Leu Leu Arg Gly Pro 
            20                  25                  30          


Ala Asp Gly Gly Ala Arg Lys Pro Ser Ala Val Glu Arg Leu Glu Ala 
        35                  40                  45              


Asp Lys Ala Lys Tyr Val Lys Ser Leu His Val Ala Asn Thr Arg Gln 
    50                  55                  60                  


Glu Pro Val Gln Pro Leu Leu Ser Lys Gln Pro Leu Phe Ser Pro Glu 
65                  70                  75                  80  


Thr Arg Arg Thr Val Leu Thr Pro Ser Arg Arg Ala Leu Pro Gly Pro 
                85                  90                  95      


Cys Arg Arg Pro Gln Leu Asp Leu Asp Ile Leu Ser Ser Leu Ile Asp 
            100                 105                 110         


Leu Cys Asp Ser Pro Val Ser Pro Ala Glu Ala Ser Arg Thr Pro Gly 
        115                 120                 125             


Arg Ala Glu Gly Ala Gly Arg Pro Pro Pro Ala Thr Pro Pro Arg Pro 
    130                 135                 140                 


Pro Pro Ser Thr Ser Ala Val Arg Arg Val Asp Val Arg Pro Leu Pro 
145                 150                 155                 160 


Ala Ser Pro Ala Arg Pro Cys Pro Ser Pro Gly Pro Ala Ala Ala Ser 
                165                 170                 175     


Ser Pro Ala Arg Pro Pro Gly Leu Gln Arg Ser Lys Ser Asp Leu Ser 
            180                 185                 190         


Glu Arg Phe Ser Arg Ala Ala Ala Asp Leu Glu Arg Phe Phe Asn Phe 
        195                 200                 205             


Cys Gly Leu Asp Pro Glu Glu Ala Arg Gly Leu Gly Val Ala His Leu 
    210                 215                 220                 


Ala Arg Ala Ser Ser Asp Ile Val Ser Leu Ala Gly Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Gly Ser Ser Glu Gly Gly Cys Ser Arg Arg Ser Ser Val Thr Val 
                245                 250                 255     


Glu Glu Arg Ala Arg Glu Arg Val Pro Tyr Gly Val Ser Val Val Glu 
            260                 265                 270         


Arg Asn Ala Arg Val Ile Lys Trp Leu Tyr Gly Leu Arg Gln Ala Arg 
        275                 280                 285             


Glu Ser Pro Ala Ala Glu Gly 
    290                 295 


<210> 6668
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6668
Met Pro Val His Thr Leu Ser Pro Gly Ala Pro Ser Ala Pro Ala Leu 
1               5                   10                  15      


Pro Cys Arg Leu Arg Thr Arg Val Pro Gly Tyr Leu Leu Arg Gly Pro 
            20                  25                  30          


Ala Asp Gly Gly Ala Arg Lys Pro Ser Ala Val Glu Arg Leu Glu Ala 
        35                  40                  45              


Asp Lys Ala Lys Tyr Val Lys Ser Leu His Val Ala Asn Thr Arg Gln 
    50                  55                  60                  


Glu Pro Val Gln Pro Leu Leu Ser Lys Gln Pro Leu Phe Ser Pro Glu 
65                  70                  75                  80  


Thr Arg Arg Thr Val Leu Thr Pro Ser Arg Arg Ala Leu Pro Gly Pro 
                85                  90                  95      


Cys Arg Arg Pro Gln Leu Asp Leu Asp Ile Leu Ser Ser Leu Ile Asp 
            100                 105                 110         


Leu Cys Asp Ser Pro Val Ser Pro Ala Glu Ala Ser Arg Thr Pro Gly 
        115                 120                 125             


Arg Ala Glu Gly Ala Gly Arg Pro Pro Pro Ala Thr Pro Pro Arg Pro 
    130                 135                 140                 


Pro Pro Ser Thr Ser Ala Val Arg Arg Val Asp Val Arg Pro Leu Pro 
145                 150                 155                 160 


Ala Ser Pro Ala Arg Pro Cys Pro Ser Pro Gly Pro Ala Ala Ala Ser 
                165                 170                 175     


Ser Pro Ala Arg Pro Pro Gly Leu Gln Arg Ser Lys Ser Asp Leu Ser 
            180                 185                 190         


Glu Arg Phe Ser Arg Ala Ala Ala Asp Leu Glu Arg Phe Phe Asn Phe 
        195                 200                 205             


Cys Gly Leu Asp Pro Glu Glu Ala Arg Gly Leu Gly Val Ala His Leu 
    210                 215                 220                 


Ala Arg Ala Ser Ser Asp Ile Val Ser Leu Ala Gly Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Gly Ser Ser Glu Gly Gly Cys Ser Arg Arg Ser Ser Val Thr Val 
                245                 250                 255     


Glu Glu Arg Ala Arg Glu Arg Val Pro Tyr Gly Val Ser Val Val Glu 
            260                 265                 270         


Arg Asn Ala Arg Val Ile Lys Trp Leu Tyr Gly Leu Arg Gln Ala Arg 
        275                 280                 285             


Glu Ser Pro Ala Ala Glu Gly 
    290                 295 


<210> 6669
<211> 137
<212> PRT
<213> Homo sapiens

<400> 6669
Met Gly Leu Arg Ala Gly Gly Thr Leu Gly Arg Ala Gly Ala Gly Arg 
1               5                   10                  15      


Gly Ala Pro Glu Gly Pro Gly Pro Ser Gly Gly Ala Gln Gly Gly Ser 
            20                  25                  30          


Ile His Ser Gly Arg Ile Ala Ala Val His Asn Val Pro Leu Ser Val 
        35                  40                  45              


Leu Ile Arg Pro Leu Pro Ser Val Leu Asp Pro Ala Lys Val Gln Ser 
    50                  55                  60                  


Leu Val Asp Thr Ile Arg Glu Asp Pro Asp Ser Val Pro Pro Ile Asp 
65                  70                  75                  80  


Val Leu Trp Ile Lys Gly Ala Gln Gly Gly Asp Tyr Phe Tyr Ser Phe 
                85                  90                  95      


Gly Gly Cys His Arg Tyr Ala Ala Tyr Gln Gln Leu Gln Arg Glu Thr 
            100                 105                 110         


Ile Pro Ala Lys Leu Val Gln Ser Thr Leu Ser Asp Leu Arg Val Tyr 
        115                 120                 125             


Leu Gly Ala Ser Thr Pro Asp Leu Gln 
    130                 135         


<210> 6670
<211> 576
<212> PRT
<213> Homo sapiens

<400> 6670
Met Lys Cys His Tyr Glu Ala Leu Gly Val Arg Arg Asp Ala Ser Glu 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Leu Asp Asn Ala Ala Glu Ala Ala Glu Gln Phe Lys Leu 
        35                  40                  45              


Ile Gln Ala Ala Tyr Asp Val Leu Ser Asp Pro Gln Glu Arg Ala Trp 
    50                  55                  60                  


Tyr Asp Asn His Arg Glu Ala Leu Leu Lys Gly Gly Phe Asp Gly Glu 
65                  70                  75                  80  


Tyr Gln Asp Asp Ser Leu Asp Leu Leu Arg Tyr Phe Thr Val Thr Cys 
                85                  90                  95      


Tyr Ser Gly Tyr Gly Asp Asp Glu Lys Gly Phe Tyr Thr Val Tyr Arg 
            100                 105                 110         


Asn Val Phe Glu Met Ile Ala Lys Glu Glu Leu Glu Ser Val Leu Glu 
        115                 120                 125             


Glu Glu Val Asp Asp Phe Pro Thr Phe Gly Asp Ser Gln Ser Asp Tyr 
    130                 135                 140                 


Asp Thr Val Val His Pro Phe Tyr Ala Tyr Trp Gln Ser Phe Cys Thr 
145                 150                 155                 160 


Gln Lys Asn Phe Ala Trp Lys Glu Glu Tyr Asp Thr Arg Gln Ala Ser 
                165                 170                 175     


Asn Arg Trp Glu Lys Arg Ala Met Glu Lys Glu Asn Lys Lys Ile Arg 
            180                 185                 190         


Asp Lys Ala Arg Lys Glu Lys Asn Glu Leu Val Arg Gln Leu Val Ala 
        195                 200                 205             


Phe Ile Arg Lys Arg Asp Lys Arg Val Gln Ala His Arg Lys Leu Val 
    210                 215                 220                 


Glu Glu Gln Asn Ala Glu Lys Ala Arg Lys Ala Glu Glu Met Arg Arg 
225                 230                 235                 240 


Gln Gln Lys Leu Lys Gln Ala Lys Leu Val Glu Gln Tyr Arg Glu Gln 
                245                 250                 255     


Ser Trp Met Thr Met Ala Asn Leu Glu Lys Glu Leu Gln Glu Met Glu 
            260                 265                 270         


Ala Arg Tyr Glu Lys Glu Phe Gly Asp Gly Ser Asp Glu Asn Glu Met 
        275                 280                 285             


Glu Glu His Glu Leu Lys Asp Glu Glu Asp Gly Lys Asp Ser Asp Glu 
    290                 295                 300                 


Ala Glu Asp Ala Glu Leu Tyr Asp Asp Leu Tyr Cys Pro Ala Cys Asp 
305                 310                 315                 320 


Lys Ser Phe Lys Thr Glu Lys Ala Met Lys Asn His Glu Lys Ser Lys 
                325                 330                 335     


Lys His Arg Glu Met Val Ala Leu Leu Lys Gln Gln Leu Glu Glu Glu 
            340                 345                 350         


Glu Glu Asn Phe Ser Arg Pro Gln Ile Asp Glu Asn Pro Leu Asp Asp 
        355                 360                 365             


Asn Ser Glu Glu Glu Met Glu Asp Ala Pro Lys Gln Lys Leu Ser Lys 
    370                 375                 380                 


Lys Gln Lys Lys Lys Lys Gln Lys Pro Ala Gln Asp Val Pro Gly Lys 
385                 390                 395                 400 


Asp Ser Tyr Leu Pro Ala Ala His Phe Gln Met Ala Trp Gly Lys Lys 
                405                 410                 415     


Cys Val Leu Gly Glu Arg Arg Asp Gly Glu Ser Glu His Lys Cys Ala 
            420                 425                 430         


Lys Met Leu Leu Glu Asn Arg Gln Asn Tyr Asp Asp Asn Phe Asn Val 
        435                 440                 445             


Asn Gly Pro Gly Glu Gly Val Lys Val Asp Pro Glu Asp Thr Asn Leu 
    450                 455                 460                 


Asn Gln Asp Ser Ala Lys Glu Leu Glu Asp Ser Pro Gln Glu Asn Val 
465                 470                 475                 480 


Ser Val Thr Glu Ile Ile Lys Pro Cys Asp Asp Pro Lys Ser Glu Ala 
                485                 490                 495     


Lys Ser Val Pro Lys Pro Lys Gly Lys Lys Thr Lys Asp Met Lys Lys 
            500                 505                 510         


Pro Val Arg Val Pro Ala Glu Pro Gln Thr Met Ser Val Leu Ile Ser 
        515                 520                 525             


Cys Thr Thr Cys His Ser Glu Phe Pro Ser Arg Asn Lys Leu Phe Asp 
    530                 535                 540                 


His Leu Lys Ala Thr Gly His Ala Arg Ala Pro Ser Ser Ser Ser Leu 
545                 550                 555                 560 


Asn Ser Ala Thr Ser Ser Gln Ser Lys Lys Glu Lys Arg Lys Asn Arg 
                565                 570                 575     


<210> 6671
<211> 265
<212> PRT
<213> Homo sapiens

<400> 6671
Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn Cys Gly His 
1               5                   10                  15      


Arg Phe His Val Leu Val Ala Ser Gln Asp Phe Val Glu Ser Val Leu 
            20                  25                  30          


Val Arg Thr Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile Val His Asp 
        35                  40                  45              


Lys Val Leu Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe Arg Ser Ser 
    50                  55                  60                  


Pro Asp Leu Thr Gly Val Val Thr Ile Tyr Glu Asp Leu Arg Arg Lys 
65                  70                  75                  80  


Gly Leu Glu Phe Pro Met Thr Asp Leu Asp Met Leu Ser Pro Ile His 
                85                  90                  95      


Thr Pro Gln Arg Thr Val Phe Asn Ser Glu Thr Gln Ser Gly Gln Asp 
            100                 105                 110         


Ser Val Gly Thr Asp Ser Ser Gln Gln Glu Asp Ser Gly Gln His Ala 
        115                 120                 125             


Ala Pro Leu Pro Ala Pro Pro Ile Leu Ser Gly Asp Thr Pro Ile Ala 
    130                 135                 140                 


Pro Thr Pro Glu Gln Ile Gly Lys Leu Arg Ser Glu Leu Glu Met Val 
145                 150                 155                 160 


Ser Gly Asn Val Arg Val Met Ser Glu Met Leu Thr Glu Leu Val Pro 
                165                 170                 175     


Thr Gln Ala Glu Pro Ala Asp Leu Glu Leu Leu Gln Glu Leu Asn Arg 
            180                 185                 190         


Thr Cys Arg Ala Met Gln Gln Arg Val Leu Glu Leu Ile Pro Gln Ile 
        195                 200                 205             


Ala Asn Glu Gln Leu Thr Glu Glu Leu Leu Ile Val Asn Asp Asn Leu 
    210                 215                 220                 


Asn Asn Val Phe Leu Arg His Glu Arg Asp Arg Gly Leu Thr Val Leu 
225                 230                 235                 240 


Pro Arg Leu Val Ser Asn Ser Trp Pro Gln Ala Val Leu Pro Pro Trp 
                245                 250                 255     


Pro Pro Lys Ala Leu Val Leu Gln Ala 
            260                 265 


<210> 6672
<211> 2090
<212> PRT
<213> Homo sapiens

<400> 6672
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu 
            100                 105                 110         


Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser 
    130                 135                 140                 


Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln 
145                 150                 155                 160 


Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser 
                165                 170                 175     


Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu 
            180                 185                 190         


Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val 
        195                 200                 205             


Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu 
    210                 215                 220                 


Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu 
225                 230                 235                 240 


Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser 
                245                 250                 255     


Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser 
            260                 265                 270         


Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser 
        275                 280                 285             


Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His 
    290                 295                 300                 


Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu 
305                 310                 315                 320 


Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn 
                325                 330                 335     


Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val 
            340                 345                 350         


Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu 
        355                 360                 365             


Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu 
    370                 375                 380                 


Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met 
385                 390                 395                 400 


Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu 
                405                 410                 415     


Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala 
            420                 425                 430         


Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala 
        435                 440                 445             


Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr 
    450                 455                 460                 


Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn 
465                 470                 475                 480 


Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Lys Leu Ala Glu 
                485                 490                 495     


Tyr Glu Asn Leu Thr Asn Lys Leu Gln Arg Asn Leu Glu Asn Val Leu 
            500                 505                 510         


Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu 
        515                 520                 525             


Gln Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys 
    530                 535                 540                 


Arg Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu 
545                 550                 555                 560 


Tyr Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro 
                565                 570                 575     


Ser Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly 
            580                 585                 590         


Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu 
        595                 600                 605             


Leu Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys 
    610                 615                 620                 


Leu Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu 
625                 630                 635                 640 


Asp Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln 
                645                 650                 655     


Arg His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu 
            660                 665                 670         


Lys Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu 
        675                 680                 685             


Ala His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu 
    690                 695                 700                 


Gln Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg 
705                 710                 715                 720 


Leu Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala 
                725                 730                 735     


Ser Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu 
            740                 745                 750         


Glu Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu 
        755                 760                 765             


Gln Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu 
    770                 775                 780                 


Arg Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg 
785                 790                 795                 800 


Glu Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala 
                805                 810                 815     


Gln Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala 
            820                 825                 830         


Leu Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln 
        835                 840                 845             


Glu Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu 
    850                 855                 860                 


Leu Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu 
865                 870                 875                 880 


Lys Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met 
                885                 890                 895     


Leu Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg 
            900                 905                 910         


Gln Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr 
        915                 920                 925             


Gln Gln Ser Leu Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His 
    930                 935                 940                 


Lys Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala 
945                 950                 955                 960 


Ser Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His 
                965                 970                 975     


Asp Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn 
            980                 985                 990         


Ile His Lys Ala Thr Cys Glu Thr  Ala Asp Arg Glu Arg  Ala Glu Met 
        995                 1000                 1005             


Ser Thr  Glu Ile Ser Arg Leu  Gln Ser Lys Ile Lys  Glu Met Gln 
    1010                 1015                 1020             


Gln Ala  Thr Ser Pro Leu Ser  Met Leu Gln Ser Gly  Cys Gln Val 
    1025                 1030                 1035             


Ile Gly  Glu Glu Glu Val Glu  Gly Asp Gly Ala Leu  Ser Leu Leu 
    1040                 1045                 1050             


Gln Gln  Gly Glu Gln Leu Leu  Glu Glu Asn Gly Asp  Val Leu Leu 
    1055                 1060                 1065             


Ser Leu  Gln Arg Ala His Glu  Gln Ala Val Lys Glu  Asn Val Lys 
    1070                 1075                 1080             


Met Ala  Thr Glu Ile Ser Arg  Leu Gln Gln Arg Leu  Gln Lys Leu 
    1085                 1090                 1095             


Glu Pro  Gly Leu Val Met Ser  Ser Cys Leu Asp Glu  Pro Ala Thr 
    1100                 1105                 1110             


Glu Phe  Phe Gly Asn Thr Ala  Glu Gln Thr Glu Gln  Phe Leu Gln 
    1115                 1120                 1125             


Gln Asn  Arg Thr Lys Gln Val  Glu Gly Val Thr Arg  Arg His Val 
    1130                 1135                 1140             


Leu Ser  Asp Leu Glu Asp Asp  Glu Val Arg Asp Leu  Gly Ser Thr 
    1145                 1150                 1155             


Gly Thr  Ser Ser Val Gln Arg  Gln Glu Val Lys Ile  Glu Glu Ser 
    1160                 1165                 1170             


Glu Ala  Ser Val Glu Gly Phe  Ser Glu Leu Glu Asn  Ser Glu Glu 
    1175                 1180                 1185             


Thr Arg  Thr Glu Ser Trp Glu  Leu Lys Asn Gln Ile  Ser Gln Leu 
    1190                 1195                 1200             


Gln Glu  Gln Leu Met Met Leu  Cys Ala Asp Cys Asp  Arg Ala Ser 
    1205                 1210                 1215             


Glu Lys  Lys Gln Asp Leu Leu  Phe Asp Val Ser Val  Leu Lys Lys 
    1220                 1225                 1230             


Lys Leu  Lys Met Leu Glu Arg  Ile Pro Glu Ala Ser  Pro Lys Tyr 
    1235                 1240                 1245             


Lys Leu  Leu Tyr Glu Asp Val  Ser Arg Glu Asn Asp  Cys Leu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Arg Met Met Glu  Thr Arg Tyr Asp Glu  Ala Leu Glu 
    1265                 1270                 1275             


Asn Asn  Lys Glu Leu Thr Ala  Glu Val Phe Arg Leu  Gln Asp Glu 
    1280                 1285                 1290             


Leu Lys  Lys Met Glu Glu Val  Thr Glu Thr Phe Leu  Ser Leu Glu 
    1295                 1300                 1305             


Lys Ser  Tyr Asp Glu Val Lys  Ile Glu Asn Glu Gly  Leu Asn Val 
    1310                 1315                 1320             


Leu Val  Leu Arg Leu Gln Gly  Lys Ile Glu Lys Leu  Gln Glu Ser 
    1325                 1330                 1335             


Val Val  Gln Arg Cys Asp Cys  Cys Leu Trp Glu Ala  Ser Leu Glu 
    1340                 1345                 1350             


Asn Leu  Glu Ile Glu Pro Asp  Gly Asn Ile Leu Gln  Leu Asn Gln 
    1355                 1360                 1365             


Thr Leu  Glu Glu Cys Val Pro  Arg Val Arg Ser Val  His His Val 
    1370                 1375                 1380             


Ile Glu  Glu Cys Lys Gln Glu  Asn Gln Tyr Leu Glu  Gly Asn Thr 
    1385                 1390                 1395             


Gln Leu  Leu Glu Lys Val Lys  Ala His Glu Ile Ala  Trp Leu His 
    1400                 1405                 1410             


Gly Thr  Ile Gln Thr His Gln  Glu Arg Pro Arg Val  Gln Asn Gln 
    1415                 1420                 1425             


Val Ile  Leu Glu Glu Asn Thr  Thr Leu Leu Gly Phe  Gln Asp Lys 
    1430                 1435                 1440             


His Phe  Gln His Gln Ala Thr  Ile Ala Glu Leu Glu  Leu Glu Lys 
    1445                 1450                 1455             


Thr Lys  Leu Gln Glu Leu Thr  Arg Lys Leu Lys Glu  Arg Val Thr 
    1460                 1465                 1470             


Ile Leu  Val Lys Gln Lys Asp  Val Leu Ser His Gly  Glu Lys Glu 
    1475                 1480                 1485             


Glu Glu  Leu Lys Ala Met Met  His Asp Leu Gln Ile  Thr Cys Ser 
    1490                 1495                 1500             


Glu Met  Gln Gln Lys Val Glu  Leu Leu Arg Tyr Glu  Ser Glu Lys 
    1505                 1510                 1515             


Leu Gln  Gln Glu Asn Ser Ile  Leu Arg Asn Glu Ile  Thr Thr Leu 
    1520                 1525                 1530             


Asn Glu  Glu Asp Ser Ile Ser  Asn Leu Lys Leu Gly  Thr Leu Asn 
    1535                 1540                 1545             


Gly Ser  Gln Glu Glu Met Trp  Gln Lys Thr Glu Thr  Val Lys Gln 
    1550                 1555                 1560             


Glu Asn  Ala Ala Val Gln Lys  Met Val Glu Asn Leu  Lys Lys Gln 
    1565                 1570                 1575             


Ile Ser  Glu Leu Lys Ile Lys  Asn Gln Gln Leu Asp  Leu Glu Asn 
    1580                 1585                 1590             


Thr Glu  Leu Ser Gln Lys Asn  Ser Gln Asn Gln Glu  Lys Leu Gln 
    1595                 1600                 1605             


Glu Leu  Asn Gln Arg Leu Thr  Glu Met Leu Cys Gln  Lys Glu Lys 
    1610                 1615                 1620             


Glu Pro  Gly Asn Ser Ala Leu  Glu Glu Arg Glu Gln  Glu Lys Phe 
    1625                 1630                 1635             


Asn Leu  Lys Glu Glu Leu Glu  Arg Cys Lys Val Gln  Ser Ser Thr 
    1640                 1645                 1650             


Leu Val  Ser Ser Leu Glu Ala  Glu Leu Ser Glu Val  Lys Ile Gln 
    1655                 1660                 1665             


Thr His  Ile Val Gln Gln Glu  Asn His Leu Leu Lys  Asp Glu Leu 
    1670                 1675                 1680             


Glu Lys  Met Lys Gln Leu His  Arg Cys Pro Asp Leu  Ser Asp Phe 
    1685                 1690                 1695             


Gln Gln  Lys Ile Ser Ser Val  Leu Ser Tyr Asn Glu  Lys Leu Leu 
    1700                 1705                 1710             


Lys Glu  Lys Glu Ala Leu Ser  Glu Glu Leu Asn Ser  Cys Val Asp 
    1715                 1720                 1725             


Lys Leu  Ala Lys Ser Ser Leu  Leu Glu His Arg Ile  Ala Thr Met 
    1730                 1735                 1740             


Lys Gln  Glu Gln Lys Ser Trp  Glu His Gln Ser Ala  Ser Leu Lys 
    1745                 1750                 1755             


Ser Gln  Leu Val Ala Ser Gln  Glu Lys Val Gln Asn  Leu Glu Asp 
    1760                 1765                 1770             


Thr Val  Gln Asn Val Asn Leu  Gln Met Ser Arg Met  Lys Ser Asp 
    1775                 1780                 1785             


Leu Arg  Val Thr Gln Gln Glu  Lys Glu Ala Leu Lys  Gln Glu Val 
    1790                 1795                 1800             


Met Ser  Leu His Lys Gln Leu  Gln Asn Ala Gly Gly  Lys Ser Trp 
    1805                 1810                 1815             


Ala Pro  Glu Ile Ala Thr His  Pro Ser Gly Leu His  Asn Gln Gln 
    1820                 1825                 1830             


Lys Arg  Leu Ser Trp Asp Lys  Leu Asp His Leu Met  Asn Glu Glu 
    1835                 1840                 1845             


Gln Gln  Leu Leu Trp Gln Glu  Asn Glu Arg Leu Gln  Thr Met Val 
    1850                 1855                 1860             


Gln Asn  Thr Lys Ala Glu Leu  Thr His Ser Arg Glu  Lys Val Arg 
    1865                 1870                 1875             


Gln Leu  Glu Ser Asn Leu Leu  Pro Lys His Gln Lys  His Leu Asn 
    1880                 1885                 1890             


Pro Ser  Gly Thr Met Asn Pro  Thr Glu Gln Glu Lys  Leu Ser Leu 
    1895                 1900                 1905             


Lys Arg  Glu Cys Asp Gln Phe  Gln Lys Glu Gln Ser  Pro Ala Asn 
    1910                 1915                 1920             


Arg Lys  Val Ser Gln Met Asn  Ser Leu Glu Gln Glu  Leu Glu Thr 
    1925                 1930                 1935             


Ile His  Leu Glu Asn Glu Gly  Leu Lys Lys Lys Gln  Val Lys Leu 
    1940                 1945                 1950             


Asp Glu  Gln Leu Met Glu Met  Gln His Leu Arg Ser  Thr Ala Thr 
    1955                 1960                 1965             


Pro Ser  Pro Ser Pro His Ala  Trp Asp Leu Gln Leu  Leu Gln Gln 
    1970                 1975                 1980             


Gln Ala  Cys Pro Met Val Pro  Arg Glu Gln Phe Leu  Gln Leu Gln 
    1985                 1990                 1995             


Arg Gln  Leu Leu Gln Ala Glu  Arg Ile Asn Gln His  Leu Gln Glu 
    2000                 2005                 2010             


Glu Leu  Glu Asn Arg Thr Ser  Glu Thr Asn Thr Pro  Gln Gly Asn 
    2015                 2020                 2025             


Gln Glu  Gln Leu Val Thr Val  Met Glu Glu Arg Met  Ile Glu Val 
    2030                 2035                 2040             


Glu Gln  Lys Leu Lys Leu Val  Lys Arg Leu Leu Gln  Glu Lys Val 
    2045                 2050                 2055             


Asn Gln  Leu Lys Glu Gln Val  Ser Leu Pro Gly His  Leu Cys Ser 
    2060                 2065                 2070             


Pro Thr  Ser His Ser Ser Phe  Asn Ser Ser Phe Thr  Ser Leu Tyr 
    2075                 2080                 2085             


Cys His  
    2090 


<210> 6673
<211> 1377
<212> PRT
<213> Homo sapiens

<400> 6673
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu 
            100                 105                 110         


Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser 
    130                 135                 140                 


Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln 
145                 150                 155                 160 


Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser 
                165                 170                 175     


Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu 
            180                 185                 190         


Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val 
        195                 200                 205             


Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu 
    210                 215                 220                 


Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu 
225                 230                 235                 240 


Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser 
                245                 250                 255     


Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser 
            260                 265                 270         


Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser 
        275                 280                 285             


Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His 
    290                 295                 300                 


Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu 
305                 310                 315                 320 


Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn 
                325                 330                 335     


Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val 
            340                 345                 350         


Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu 
        355                 360                 365             


Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu 
    370                 375                 380                 


Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met 
385                 390                 395                 400 


Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu 
                405                 410                 415     


Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala 
            420                 425                 430         


Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala 
        435                 440                 445             


Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr 
    450                 455                 460                 


Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn 
465                 470                 475                 480 


Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Lys Leu Ala Glu 
                485                 490                 495     


Tyr Glu Asn Leu Thr Asn Lys Leu Gln Arg Asn Leu Glu Asn Val Leu 
            500                 505                 510         


Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu 
        515                 520                 525             


Gln Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys 
    530                 535                 540                 


Arg Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu 
545                 550                 555                 560 


Tyr Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro 
                565                 570                 575     


Ser Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly 
            580                 585                 590         


Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu 
        595                 600                 605             


Leu Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys 
    610                 615                 620                 


Leu Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu 
625                 630                 635                 640 


Asp Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln 
                645                 650                 655     


Arg His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu 
            660                 665                 670         


Lys Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu 
        675                 680                 685             


Ala His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu 
    690                 695                 700                 


Gln Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg 
705                 710                 715                 720 


Leu Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala 
                725                 730                 735     


Ser Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu 
            740                 745                 750         


Glu Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu 
        755                 760                 765             


Gln Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu 
    770                 775                 780                 


Arg Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg 
785                 790                 795                 800 


Tyr Glu Ser Glu Lys Leu Gln Gln Glu Asn Ser Ile Leu Arg Asn Glu 
                805                 810                 815     


Ile Thr Thr Leu Asn Glu Glu Asp Ser Ile Ser Asn Leu Lys Leu Gly 
            820                 825                 830         


Thr Leu Asn Gly Ser Gln Glu Glu Met Trp Gln Lys Thr Glu Thr Val 
        835                 840                 845             


Lys Gln Glu Asn Ala Ala Val Gln Lys Met Val Glu Asn Leu Lys Lys 
    850                 855                 860                 


Gln Ile Ser Glu Leu Lys Ile Lys Asn Gln Gln Leu Asp Leu Glu Asn 
865                 870                 875                 880 


Thr Glu Leu Ser Gln Lys Asn Ser Gln Asn Gln Glu Lys Leu Gln Glu 
                885                 890                 895     


Leu Asn Gln Arg Leu Thr Glu Met Leu Cys Gln Lys Glu Lys Glu Pro 
            900                 905                 910         


Gly Asn Ser Ala Leu Glu Glu Arg Glu Gln Glu Lys Phe Asn Leu Lys 
        915                 920                 925             


Glu Glu Leu Glu Arg Cys Lys Val Gln Ser Ser Thr Leu Val Ser Ser 
    930                 935                 940                 


Leu Glu Ala Glu Leu Ser Glu Val Lys Ile Gln Thr His Ile Val Gln 
945                 950                 955                 960 


Gln Glu Asn His Leu Leu Lys Asp Glu Leu Glu Lys Met Lys Gln Leu 
                965                 970                 975     


His Arg Cys Pro Asp Leu Ser Asp Phe Gln Gln Lys Ile Ser Ser Val 
            980                 985                 990         


Leu Ser Tyr Asn Glu Lys Leu Leu  Lys Glu Lys Glu Ala  Leu Ser Glu 
        995                 1000                 1005             


Glu Leu  Asn Ser Cys Val Asp  Lys Leu Ala Lys Ser  Ser Leu Leu 
    1010                 1015                 1020             


Glu His  Arg Ile Ala Thr Met  Lys Gln Glu Gln Lys  Ser Trp Glu 
    1025                 1030                 1035             


His Gln  Ser Ala Ser Leu Lys  Ser Gln Leu Val Ala  Ser Gln Glu 
    1040                 1045                 1050             


Lys Val  Gln Asn Leu Glu Asp  Thr Val Gln Asn Val  Asn Leu Gln 
    1055                 1060                 1065             


Met Ser  Arg Met Lys Ser Asp  Leu Arg Val Thr Gln  Gln Glu Lys 
    1070                 1075                 1080             


Glu Ala  Leu Lys Gln Glu Val  Met Ser Leu His Lys  Gln Leu Gln 
    1085                 1090                 1095             


Asn Ala  Gly Gly Lys Ser Trp  Ala Pro Glu Ile Ala  Thr His Pro 
    1100                 1105                 1110             


Ser Gly  Leu His Asn Gln Gln  Lys Arg Leu Ser Trp  Asp Lys Leu 
    1115                 1120                 1125             


Asp His  Leu Met Asn Glu Glu  Gln Gln Leu Leu Trp  Gln Glu Asn 
    1130                 1135                 1140             


Glu Arg  Leu Gln Thr Met Val  Gln Asn Thr Lys Ala  Glu Leu Thr 
    1145                 1150                 1155             


His Ser  Arg Glu Lys Val Arg  Gln Leu Glu Ser Asn  Leu Leu Pro 
    1160                 1165                 1170             


Lys His  Gln Lys His Leu Asn  Pro Ser Gly Thr Met  Asn Pro Thr 
    1175                 1180                 1185             


Glu Gln  Glu Lys Leu Ser Leu  Lys Arg Glu Cys Asp  Gln Phe Gln 
    1190                 1195                 1200             


Lys Glu  Gln Ser Pro Ala Asn  Arg Lys Val Ser Gln  Met Asn Ser 
    1205                 1210                 1215             


Leu Glu  Gln Glu Leu Glu Thr  Ile His Leu Glu Asn  Glu Gly Leu 
    1220                 1225                 1230             


Lys Lys  Lys Gln Val Lys Leu  Asp Glu Gln Leu Met  Glu Met Gln 
    1235                 1240                 1245             


His Leu  Arg Ser Thr Ala Thr  Pro Ser Pro Ser Pro  His Ala Trp 
    1250                 1255                 1260             


Asp Leu  Gln Leu Leu Gln Gln  Gln Ala Cys Pro Met  Val Pro Arg 
    1265                 1270                 1275             


Glu Gln  Phe Leu Gln Leu Gln  Arg Gln Leu Leu Gln  Ala Glu Arg 
    1280                 1285                 1290             


Ile Asn  Gln His Leu Gln Glu  Glu Leu Glu Asn Arg  Thr Ser Glu 
    1295                 1300                 1305             


Thr Asn  Thr Pro Gln Gly Asn  Gln Glu Gln Leu Val  Thr Val Met 
    1310                 1315                 1320             


Glu Glu  Arg Met Ile Glu Val  Glu Gln Lys Leu Lys  Leu Val Lys 
    1325                 1330                 1335             


Arg Leu  Leu Gln Glu Lys Val  Asn Gln Leu Lys Glu  Gln Val Ser 
    1340                 1345                 1350             


Leu Pro  Gly His Leu Cys Ser  Pro Thr Ser His Ser  Ser Phe Asn 
    1355                 1360                 1365             


Ser Ser  Phe Thr Ser Leu Tyr  Cys His 
    1370                 1375         


<210> 6674
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 6674
Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr His Ser Gly Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln Pro Ala Ser Gly Val Ala 
            20                  25                  30          


Tyr Ser His Pro Thr Thr Val Ala Ser Tyr Thr Val His Gln Ala Pro 
        35                  40                  45              


Val Ala Ala His Thr Val Thr Ala Ala Tyr Ala Pro Ala Ala Ala Thr 
    50                  55                  60                  


Val Ala Val Ala Arg Pro Ala Pro Val Ala Val Ala Ala Ala Ala Thr 
65                  70                  75                  80  


Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala His Thr Ala Thr Asp Tyr 
                85                  90                  95      


Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro Pro Pro Pro Pro Pro Ala 
            100                 105                 110         


Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser Tyr Val Arg Ser Thr Ala 
        115                 120                 125             


Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr Tyr Gln Gln Pro Thr Ala 
    130                 135                 140                 


Thr Ala Ala Ala Val Ala Ala Ala Ala Gln Pro Gln Pro Ser Val Ala 
145                 150                 155                 160 


Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala Gly Tyr Ser Gln Gly Ala 
                165                 170                 175     


Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg Gln Val Thr Ala Ile Lys 
            180                 185                 190         


Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr Phe Ser Ile Tyr Pro Val 
        195                 200                 205             


Ser Ser Thr Val Gln Pro Val Ala Ala Ala Ala Thr Val Val Pro Ser 
    210                 215                 220                 


Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr Ala Val Thr Tyr Ser Gly 
225                 230                 235                 240 


Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val Tyr Ser Ala Ala Ser Ser 
                245                 250                 255     


Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys Gln Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr Gly Thr Thr Phe Thr Lys 
        275                 280                 285             


Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys Pro Lys Gln Pro Pro Lys 
    290                 295                 300                 


Pro Pro Gln Ile His Tyr Cys Asp Val Cys Lys Ile Ser Cys Ala Gly 
305                 310                 315                 320 


Pro Gln Thr Tyr Lys Glu His Leu Glu Gly Gln Lys His Lys Lys Lys 
                325                 330                 335     


Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr Ser Ser Ser Asn Ser Ser 
            340                 345                 350         


Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys Glu Leu Cys Asp Val Ser 
        355                 360                 365             


Cys Thr Gly Ala Asp Ala Tyr Ala Ala His Ile Arg Gly Ala Lys His 
    370                 375                 380                 


Gln Lys Val Val Lys Leu His Thr Lys Leu Gly Lys Pro Ile Pro Ser 
385                 390                 395                 400 


Thr Glu Pro Asn Val Val Ser Gln Ala Thr Ser Ser Thr Ala Val Ser 
                405                 410                 415     


Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser Ile Ala Ala Asn Asn Cys 
            420                 425                 430         


Thr Val Asn Thr Ser Ser Val Ala Thr Ser Ser Met Lys Gly Leu Thr 
        435                 440                 445             


Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr Ser Asn Thr Lys Val Ser 
    450                 455                 460                 


Ala Val Pro Thr Asn Met Ala Ala Lys Lys Thr Ser Thr Pro Lys Ile 
465                 470                 475                 480 


Asn Phe Val Gly Gly Asn Lys Leu Gln Ser Thr Gly Asn Lys Ala Glu 
                485                 490                 495     


Asp Ile Lys Gly Thr Glu Cys Val Lys Ser Thr Pro Val Thr Ser Ala 
            500                 505                 510         


Val Gln Ile Pro Glu Val Lys Gln Asp Thr Val Ser Glu Pro Val Thr 
        515                 520                 525             


Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp Val Gln Pro Val Gly His 
    530                 535                 540                 


Asp Tyr Val Glu Glu Val Arg Asn Asp Glu Gly Lys Val Ile Arg Phe 
545                 550                 555                 560 


His Cys Lys Leu Cys Glu Cys Ser Phe Asn Asp Pro Asn Ala Lys Glu 
                565                 570                 575     


Met His Leu Lys Gly Arg Arg His Arg Leu Gln Tyr Lys Lys Lys Val 
            580                 585                 590         


Asn Pro Asp Leu Gln Val Glu Val Lys Pro Ser Ile Arg Ala Arg Lys 
        595                 600                 605             


Ile Gln Glu Glu Lys Met Arg Lys Gln Met Gln Lys Glu Glu Tyr Trp 
    610                 615                 620                 


Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg Met Glu Met Arg Arg Tyr 
625                 630                 635                 640 


Glu Glu Asp Met Tyr Trp Arg Arg Met Glu Glu Glu Gln His His Trp 
                645                 650                 655     


Asp Asp Arg Arg Arg Met Pro Asp Gly Gly Tyr Pro His Gly Pro Pro 
            660                 665                 670         


Gly Pro Leu Gly Leu Leu Gly Val Arg Pro Gly Met Pro Pro Gln Pro 
        675                 680                 685             


Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp Ser Ser Asp Asp Arg Tyr 
    690                 695                 700                 


Val Met Thr Lys His Ala Thr Ile Tyr Pro Thr Glu Glu Glu Leu Gln 
705                 710                 715                 720 


Ala Val Gln Lys Ile Val Ser Ile Thr Glu Arg Ala Leu Lys Leu Val 
                725                 730                 735     


Ser Asp Ser Leu Ser Glu His Glu Lys Asn Lys Asn Lys Glu Gly Asp 
            740                 745                 750         


Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala Leu Lys Gly Val Leu Arg 
        755                 760                 765             


Val Gly Val Leu Ala Lys Gly Leu Leu Leu Arg Gly Asp Arg Asn Val 
    770                 775                 780                 


Asn Leu Val Leu Leu Cys Ser Glu Lys Pro Ser Lys Thr Leu Leu Ser 
785                 790                 795                 800 


Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu Ala Val Ile Ser Pro Glu 
                805                 810                 815     


Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu Ala Ala Ile Ile Leu Asn 
            820                 825                 830         


Ser Cys Val Glu Pro Lys Met Gln Val Thr Ile Thr Leu Thr Ser Pro 
        835                 840                 845             


Ile Ile Arg Glu Glu Asn Met Arg Glu Gly Asp Val Thr Ser Gly Met 
    850                 855                 860                 


Val Lys Asp Pro Pro Asp Val Leu Asp Arg Gln Lys Cys Leu Asp Ala 
865                 870                 875                 880 


Leu Ala Ala Leu Arg His Ala Lys Trp Phe Gln Gln Ala Arg Ala Asn 
                885                 890                 895     


Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile Leu Arg Asp Leu Cys 
            900                 905                 910         


Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser Trp Ala Met Glu Leu 
        915                 920                 925             


Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser Pro Gln Ser Pro Gly 
    930                 935                 940                 


Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser Ser Gly Ile Ile Leu 
945                 950                 955                 960 


Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys Asp Pro Phe Asp 
                965                 970                 975     


Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu Asp Ile Thr Ser Ser 
            980                 985                 990         


Ala Gln Phe Ala Leu Arg Leu Leu  Ala Phe Arg Gln Ile  His Lys Val 
        995                 1000                 1005             


Leu Gly  Met Asp Pro Leu Pro  Gln Met Ser Gln Arg  Phe Asn Ile 
    1010                 1015                 1020             


His Asn  Asn Arg Lys Arg Arg  Arg Asp Ser Asp Gly  Met Asp Leu 
    1025                 1030                 1035             


Lys Leu  Arg Gly Lys Lys Thr  Lys Lys Ile Met Ile  Thr Phe Lys 
    1040                 1045                 1050             


Lys Cys  Leu 
    1055     


<210> 6675
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6675
Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Ile 
            20                  25                  30          


Cys Cys Cys Lys Pro Val Cys Cys Cys Val Pro Ala Cys Ser Cys Thr 
        35                  40                  45              


Ser Cys Gly Ser Cys Gly Gly Ser Lys Gly Cys Cys Gly Ser Cys Gly 
    50                  55                  60                  


Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys 
65                  70                  75                  80  


Gly Ser Cys Gly Cys Ser Gln Cys Ser Cys Cys Lys Pro Cys Tyr Cys 
                85                  90                  95      


Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys Pro 
            100                 105                 110         


Cys Cys Ser Gln Ala Ser Cys Cys Val Pro Ile Cys Cys Gln Cys Lys 
        115                 120                 125             


Ile 
    


<210> 6676
<211> 447
<212> PRT
<213> Homo sapiens

<400> 6676
Met Pro Met Pro Thr Glu Gly Thr Pro Pro Pro Leu Ser Gly Thr Pro 
1               5                   10                  15      


Ile Pro Val Pro Ala Tyr Phe Arg His Ala Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Lys Arg Pro Arg Gly Leu Ser Arg Ser Leu Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Lys Gly Ser Ile Pro Ile Ser Arg Leu Phe Pro Pro Arg Thr Pro Gly 
    50                  55                  60                  


Trp His Gln Leu Gln Pro Arg Arg Val Ser Phe Arg Gly Glu Ala Ser 
65                  70                  75                  80  


Glu Thr Leu Gln Ser Pro Gly Tyr Asp Pro Ser Arg Pro Glu Ser Phe 
                85                  90                  95      


Phe Gln Gln Ser Phe Gln Arg Leu Ser Arg Leu Gly His Gly Ser Tyr 
            100                 105                 110         


Gly Glu Val Phe Lys Val Arg Ser Lys Glu Asp Gly Arg Leu Tyr Ala 
        115                 120                 125             


Val Lys Arg Ser Met Ser Pro Phe Arg Gly Pro Lys Asp Arg Ala Arg 
    130                 135                 140                 


Lys Leu Ala Glu Val Gly Ser His Glu Lys Val Gly Gln His Pro Cys 
145                 150                 155                 160 


Cys Val Arg Leu Glu Gln Ala Trp Glu Glu Gly Gly Ile Leu Tyr Leu 
                165                 170                 175     


Gln Thr Glu Leu Cys Gly Pro Ser Leu Gln Gln His Cys Glu Ala Trp 
            180                 185                 190         


Gly Ala Ser Leu Pro Glu Ala Gln Val Trp Gly Tyr Leu Arg Asp Thr 
        195                 200                 205             


Leu Leu Ala Leu Ala His Leu His Ser Gln Gly Leu Val His Leu Asp 
    210                 215                 220                 


Val Lys Pro Ala Asn Ile Phe Leu Gly Pro Arg Gly Arg Cys Lys Leu 
225                 230                 235                 240 


Gly Asp Phe Gly Leu Leu Val Glu Leu Gly Thr Ala Gly Ala Gly Glu 
                245                 250                 255     


Val Gln Glu Gly Asp Pro Arg Tyr Met Ala Pro Glu Leu Leu Gln Gly 
            260                 265                 270         


Ser Tyr Gly Thr Ala Ala Asp Val Phe Ser Leu Gly Leu Thr Ile Leu 
        275                 280                 285             


Glu Val Ala Cys Asn Met Glu Leu Pro His Gly Gly Glu Gly Trp Gln 
    290                 295                 300                 


Gln Leu Arg Gln Gly Tyr Leu Pro Pro Glu Phe Thr Ala Gly Leu Ser 
305                 310                 315                 320 


Ser Glu Leu Arg Ser Val Leu Val Met Met Leu Glu Pro Asp Pro Lys 
                325                 330                 335     


Leu Arg Ala Thr Ala Glu Ala Leu Leu Ala Leu Pro Val Leu Arg Gln 
            340                 345                 350         


Pro Arg Ala Trp Gly Val Leu Trp Cys Met Ala Ala Glu Ala Leu Ser 
        355                 360                 365             


Arg Gly Trp Ala Leu Trp Gln Ala Leu Leu Ala Leu Leu Cys Trp Leu 
    370                 375                 380                 


Trp His Gly Leu Ala His Pro Ala Ser Trp Leu Gln Pro Leu Gly Pro 
385                 390                 395                 400 


Pro Ala Thr Pro Pro Gly Ser Pro Pro Cys Ser Leu Leu Leu Asp Ser 
                405                 410                 415     


Ser Leu Ser Ser Asn Trp Asp Asp Asp Ser Leu Gly Pro Cys Val Leu 
            420                 425                 430         


Lys Arg Thr Glu Gly Ala Leu Glu Cys Ser Gln Met Glu Gly Leu 
        435                 440                 445         


<210> 6677
<211> 334
<212> PRT
<213> Homo sapiens

<400> 6677
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
                325                 330                 


<210> 6678
<211> 390
<212> PRT
<213> Homo sapiens

<400> 6678
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr Gln Leu 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe 
            340                 345                 350         


His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln 
        355                 360                 365             


Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys 
    370                 375                 380                 


Leu Ile Gln Arg Arg Asp 
385                 390 


<210> 6679
<211> 390
<212> PRT
<213> Homo sapiens

<400> 6679
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr Gln Leu 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe 
            340                 345                 350         


His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln 
        355                 360                 365             


Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys 
    370                 375                 380                 


Leu Ile Gln Arg Arg Asp 
385                 390 


<210> 6680
<211> 366
<212> PRT
<213> Homo sapiens

<400> 6680
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr Gln Leu 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Ala Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Phe His Val Tyr Asn Tyr Gln Met Pro 
                325                 330                 335     


Pro Gln Cys Pro Val Gly Glu Gln Arg Arg Asn Leu Trp Thr Glu Ala 
            340                 345                 350         


Tyr Lys Trp Trp Tyr Leu Val Cys Leu Ile Gln Arg Arg Asp 
        355                 360                 365     


<210> 6681
<211> 382
<212> PRT
<213> Homo sapiens

<400> 6681
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
            340                 345                 350         


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
        355                 360                 365             


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
    370                 375                 380         


<210> 6682
<211> 613
<212> PRT
<213> Homo sapiens

<400> 6682
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser 
                165                 170                 175     


Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser 
            180                 185                 190         


Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe 
        195                 200                 205             


Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys 
    210                 215                 220                 


Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg 
225                 230                 235                 240 


Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val 
                245                 250                 255     


Asp Val Gln Lys Ile Val Gly Ser Gln Ile His Phe His Gly Lys Lys 
            260                 265                 270         


Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His 
        275                 280                 285             


Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe 
    290                 295                 300                 


Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln 
305                 310                 315                 320 


Ile Thr Pro Asn Pro Val Thr Gln His Val Gln Ser Ala Ala Asn Pro 
                325                 330                 335     


Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser 
            340                 345                 350         


Ser Ala Ala Ala Ser Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val 
        355                 360                 365             


Pro Asn Thr Val Phe Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr 
    370                 375                 380                 


Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys 
385                 390                 395                 400 


Ile Ile Thr Asn Arg Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser 
                405                 410                 415     


Phe Val Asn Asp Val Asp Val Gln Lys Ile Val Gly Ser Gln Ile His 
            420                 425                 430         


Phe His Gly Lys Lys Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys 
        435                 440                 445             


Leu Cys Ala Arg His Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro 
    450                 455                 460                 


Pro Pro Pro Gln Phe Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr 
465                 470                 475                 480 


Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro Val Thr Gln His Val Gln 
                485                 490                 495     


Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly Gln Val Ile Thr Gly Cys 
            500                 505                 510         


Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr Pro Thr Tyr Pro Asp Ser 
        515                 520                 525             


Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
    530                 535                 540                 


Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe Gln Val Thr Ala Gly Tyr 
545                 550                 555                 560 


Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser 
                565                 570                 575     


Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe Pro Val Cys Glu Ile Cys 
            580                 585                 590         


Lys Ile Leu Val Leu Lys Asn Ala Ala Ala Phe Leu Cys His Ser Lys 
        595                 600                 605             


Val Asn Arg Ser Ile 
    610             


<210> 6683
<211> 127
<212> PRT
<213> Homo sapiens

<400> 6683
Met Arg Pro Leu Asp Ile Val Glu Leu Ala Glu Pro Glu Glu Val Glu 
1               5                   10                  15      


Val Leu Glu Pro Glu Glu Asp Phe Glu Gln Phe Leu Leu Pro Val Ile 
            20                  25                  30          


Asn Glu Met Arg Glu Asp Ile Ala Ser Leu Thr Arg Glu His Gly Arg 
        35                  40                  45              


Ala Tyr Leu Arg Asn Arg Ser Lys Leu Trp Glu Met Asp Asn Met Leu 
    50                  55                  60                  


Ile Gln Ile Lys Thr Gln Val Glu Ala Ser Glu Glu Ser Ala Leu Asn 
65                  70                  75                  80  


His Leu Gln Asn Pro Gly Asp Ala Ala Glu Gly Arg Ala Ala Lys Arg 
                85                  90                  95      


Cys Glu Lys Ala Glu Glu Lys Ala Lys Glu Ile Ala Lys Met Ala Glu 
            100                 105                 110         


Met Leu Val Glu Leu Val Arg Arg Ile Glu Lys Ser Glu Ser Ser 
        115                 120                 125         


<210> 6684
<211> 178
<212> PRT
<213> Homo sapiens

<400> 6684
Met Met Arg Ala Met Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe 
1               5                   10                  15      


Gly Ser Pro Glu Glu Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ala 
            20                  25                  30          


Ser Asn Ile Phe Gly Pro Thr Glu Glu Pro Gln Asn Ile Pro Lys Arg 
        35                  40                  45              


Thr Asn Pro Pro Gly Gly Lys Gly Ser Gly Ile Phe Asp Glu Ser Thr 
    50                  55                  60                  


Pro Val Gln Thr Arg Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser 
65                  70                  75                  80  


Asp Ile Phe Gly Ser Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro 
                85                  90                  95      


Asn Lys Pro Lys Asp His Val Phe Leu Cys Glu Gly Glu Glu Pro Lys 
            100                 105                 110         


Ser Asp Leu Lys Ala Ala Arg Ser Ile Pro Ala Gly Ala Glu Pro Gly 
        115                 120                 125             


Glu Lys Gly Ser Ala Arg Lys Ala Gly Pro Ala Lys Glu Gln Glu Pro 
    130                 135                 140                 


Met Pro Thr Val Asp Ser His Glu Pro Arg Leu Gly Pro Arg Pro Arg 
145                 150                 155                 160 


Ser His Asn Lys Val Leu Asn Pro Pro Gly Gly Lys Ser Ser Ile Ser 
                165                 170                 175     


Phe Tyr 
        


<210> 6685
<211> 218
<212> PRT
<213> Homo sapiens

<400> 6685
Met Phe Gln Val Pro Asp Ser Glu Gly Gly Arg Ala Gly Ser Arg Lys 
1               5                   10                  15      


Trp Gln Leu Leu Thr Gly Ser Leu Ala Ser Thr Ser Pro Ser Leu Leu 
            20                  25                  30          


Ser Gly Gln Gly Pro Trp Ala Pro Leu Gln Arg Ala Met Lys Pro Pro 
        35                  40                  45              


Gly Gly Glu Ser Ser Asn Leu Phe Gly Ser Pro Glu Glu Ala Thr Pro 
    50                  55                  60                  


Ser Ser Arg Pro Asn Arg Met Ala Ser Asn Ile Phe Gly Pro Thr Glu 
65                  70                  75                  80  


Glu Pro Gln Asn Ile Pro Lys Arg Thr Asn Pro Pro Gly Gly Lys Gly 
                85                  90                  95      


Ser Gly Ile Phe Asp Glu Ser Thr Pro Val Gln Thr Arg Gln His Leu 
            100                 105                 110         


Asn Pro Pro Gly Gly Lys Thr Ser Asp Ile Phe Gly Ser Pro Val Thr 
        115                 120                 125             


Ala Thr Ser Arg Leu Ala His Pro Asn Lys Pro Lys Asp His Val Phe 
    130                 135                 140                 


Leu Cys Glu Gly Glu Glu Pro Lys Ser Asp Leu Lys Ala Ala Arg Ser 
145                 150                 155                 160 


Ile Pro Ala Gly Ala Glu Pro Gly Glu Lys Gly Ser Ala Arg Lys Ala 
                165                 170                 175     


Gly Pro Ala Lys Glu Gln Glu Pro Met Pro Thr Val Asp Ser His Glu 
            180                 185                 190         


Pro Arg Leu Gly Pro Arg Pro Arg Ser His Asn Lys Val Leu Asn Pro 
        195                 200                 205             


Pro Gly Gly Lys Ser Ser Ile Ser Phe Tyr 
    210                 215             


<210> 6686
<211> 1621
<212> PRT
<213> Homo sapiens

<400> 6686
Met Ala Gly Gly Arg Gly Ala Pro Gly Arg Gly Arg Asp Glu Pro Pro 
1               5                   10                  15      


Glu Ser Tyr Pro Gln Arg Gln Asp His Glu Leu Gln Ala Leu Glu Ala 
            20                  25                  30          


Ile Tyr Gly Ala Asp Phe Gln Asp Leu Arg Pro Asp Ala Cys Gly Pro 
        35                  40                  45              


Val Lys Glu Pro Pro Glu Ile Asn Leu Val Leu Tyr Pro Gln Gly Leu 
    50                  55                  60                  


Thr Gly Glu Glu Val Tyr Val Lys Val Asp Leu Arg Val Lys Cys Pro 
65                  70                  75                  80  


Pro Thr Tyr Pro Asp Val Val Pro Glu Ile Glu Leu Lys Asn Ala Lys 
                85                  90                  95      


Gly Leu Ser Asn Glu Ser Val Asn Leu Leu Lys Ser Arg Leu Glu Glu 
            100                 105                 110         


Leu Ala Lys Lys His Cys Gly Glu Val Met Ile Phe Glu Leu Ala Tyr 
        115                 120                 125             


His Val Gln Ser Phe Leu Ser Glu His Asn Lys Pro Pro Pro Lys Ser 
    130                 135                 140                 


Phe His Glu Glu Met Leu Glu Arg Arg Ala Gln Glu Glu Gln Gln Arg 
145                 150                 155                 160 


Leu Leu Glu Ala Lys Arg Lys Glu Glu Gln Glu Gln Arg Glu Ile Leu 
                165                 170                 175     


His Glu Ile Gln Arg Arg Lys Glu Glu Ile Lys Glu Glu Lys Lys Arg 
            180                 185                 190         


Lys Glu Met Ala Lys Gln Glu Arg Leu Glu Ile Ala Ser Leu Ser Asn 
        195                 200                 205             


Gln Asp His Thr Ser Lys Lys Asp Pro Gly Gly His Arg Thr Ala Ala 
    210                 215                 220                 


Ile Leu His Gly Gly Ser Pro Asp Phe Val Gly Asn Gly Lys His Arg 
225                 230                 235                 240 


Ala Asn Ser Ser Gly Arg Ser Arg Arg Glu Arg Gln Tyr Ser Val Cys 
                245                 250                 255     


Asn Ser Glu Asp Ser Pro Gly Ser Cys Glu Ile Leu Tyr Phe Asn Met 
            260                 265                 270         


Gly Ser Pro Asp Gln Leu Met Val His Lys Gly Lys Cys Ile Gly Ser 
        275                 280                 285             


Asp Glu Gln Leu Gly Lys Leu Val Tyr Asn Ala Leu Glu Thr Ala Thr 
    290                 295                 300                 


Gly Gly Phe Val Leu Leu Tyr Glu Trp Val Leu Gln Trp Gln Lys Lys 
305                 310                 315                 320 


Met Gly Pro Phe Leu Thr Ser Gln Glu Lys Glu Lys Ile Asp Lys Cys 
                325                 330                 335     


Lys Lys Gln Ile Gln Gly Thr Glu Thr Glu Phe Asn Ser Leu Val Lys 
            340                 345                 350         


Leu Ser His Pro Asn Val Val Arg Tyr Leu Ala Met Asn Leu Lys Glu 
        355                 360                 365             


Gln Asp Asp Ser Ile Val Val Asp Ile Leu Val Glu His Ile Ser Gly 
    370                 375                 380                 


Val Ser Leu Ala Ala His Leu Ser His Ser Gly Pro Ile Pro Val His 
385                 390                 395                 400 


Gln Leu Arg Arg Tyr Thr Ala Gln Leu Leu Ser Gly Leu Asp Tyr Leu 
                405                 410                 415     


His Ser Asn Ser Val Val His Lys Val Leu Ser Ala Ser Asn Val Leu 
            420                 425                 430         


Val Asp Ala Glu Gly Thr Val Lys Ile Thr Asp Tyr Ser Ile Ser Lys 
        435                 440                 445             


Arg Leu Ala Asp Ile Cys Lys Glu Asp Val Phe Glu Gln Thr Arg Val 
    450                 455                 460                 


Arg Phe Ser Asp Asn Ala Leu Pro Tyr Lys Thr Gly Lys Lys Gly Asp 
465                 470                 475                 480 


Val Trp Arg Leu Gly Leu Leu Leu Leu Ser Leu Ser Gln Gly Gln Glu 
                485                 490                 495     


Cys Gly Glu Tyr Pro Val Thr Ile Pro Ser Asp Leu Pro Ala Asp Phe 
            500                 505                 510         


Gln Asp Phe Leu Lys Lys Cys Val Cys Leu Asp Asp Lys Glu Arg Trp 
        515                 520                 525             


Ser Pro Gln Gln Leu Leu Lys His Ser Phe Ile Asn Pro Gln Pro Lys 
    530                 535                 540                 


Met Pro Leu Val Glu Gln Ser Pro Glu Asp Ser Glu Gly Gln Asp Tyr 
545                 550                 555                 560 


Val Glu Thr Val Ile Pro Ser Asn Arg Leu Pro Ser Ala Ala Phe Phe 
                565                 570                 575     


Ser Glu Thr Gln Arg Gln Phe Ser Arg Tyr Phe Ile Glu Phe Glu Glu 
            580                 585                 590         


Leu Gln Leu Leu Gly Lys Gly Ala Phe Gly Ala Val Ile Lys Val Gln 
        595                 600                 605             


Asn Lys Leu Asp Gly Cys Cys Tyr Ala Val Lys Arg Ile Pro Ile Asn 
    610                 615                 620                 


Pro Ala Ser Arg Gln Phe Arg Arg Ile Lys Gly Glu Val Thr Leu Leu 
625                 630                 635                 640 


Ser Arg Leu His His Glu Asn Ile Val Arg Tyr Tyr Asn Ala Trp Ile 
                645                 650                 655     


Glu Arg His Glu Arg Pro Ala Gly Pro Gly Thr Pro Pro Pro Asp Ser 
            660                 665                 670         


Gly Pro Leu Ala Lys Asp Asp Arg Ala Ala Arg Gly Gln Pro Ala Ser 
        675                 680                 685             


Asp Thr Asp Gly Leu Asp Ser Val Glu Ala Ala Ala Pro Pro Pro Ile 
    690                 695                 700                 


Leu Ser Ser Ser Val Glu Trp Ser Thr Ser Gly Glu Arg Ser Ala Ser 
705                 710                 715                 720 


Ala Arg Phe Pro Ala Thr Gly Pro Gly Ser Ser Asp Asp Glu Asp Asp 
                725                 730                 735     


Asp Glu Asp Glu His Gly Gly Val Phe Ser Gln Ser Phe Leu Pro Ala 
            740                 745                 750         


Ser Asp Ser Glu Ser Asp Ile Ile Phe Asp Asn Glu Asp Glu Asn Ser 
        755                 760                 765             


Lys Ser Gln Asn Gln Met Glu Tyr Cys Glu Lys Ser Thr Leu Arg Asp 
    770                 775                 780                 


Thr Ile Asp Gln Gly Leu Tyr Arg Asp Thr Val Arg Leu Trp Arg Leu 
785                 790                 795                 800 


Phe Arg Glu Ile Leu Asp Gly Leu Ala Tyr Ile His Glu Lys Gly Met 
                805                 810                 815     


Ile His Arg Asp Leu Lys Pro Val Asn Ile Phe Leu Asp Ser Asp Asp 
            820                 825                 830         


His Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Asp His Leu Ala Phe 
        835                 840                 845             


Ser Ala Asp Ser Lys Gln Asp Asp Gln Thr Gly Asp Leu Ile Lys Ser 
    850                 855                 860                 


Asp Pro Ser Gly His Leu Thr Gly Met Val Gly Thr Ala Leu Tyr Val 
865                 870                 875                 880 


Ser Pro Glu Val Gln Gly Ser Thr Lys Ser Ala Tyr Asn Gln Lys Val 
                885                 890                 895     


Asp Leu Phe Ser Leu Gly Ile Ile Phe Phe Glu Met Ser Tyr His Pro 
            900                 905                 910         


Met Val Thr Ala Ser Glu Arg Ile Phe Val Leu Asn Gln Leu Arg Asp 
        915                 920                 925             


Pro Thr Ser Pro Lys Phe Pro Glu Asp Phe Asp Asp Gly Glu His Ala 
    930                 935                 940                 


Lys Gln Lys Ser Val Ile Ser Trp Leu Leu Asn His Asp Pro Ala Lys 
945                 950                 955                 960 


Arg Pro Thr Ala Thr Glu Leu Leu Lys Ser Glu Leu Leu Pro Pro Pro 
                965                 970                 975     


Gln Met Glu Glu Ser Glu Leu His Glu Val Leu His His Thr Leu Thr 
            980                 985                 990         


Asn Val Asp Gly Lys Ala Tyr Arg  Thr Met Met Ala Gln  Ile Phe Ser 
        995                 1000                 1005             


Gln Arg  Ile Ser Pro Ala Ile  Asp Tyr Thr Tyr Asp  Ser Asp Ile 
    1010                 1015                 1020             


Leu Lys  Gly Asn Phe Ser Ile  Arg Thr Ala Lys Met  Gln Gln His 
    1025                 1030                 1035             


Val Cys  Glu Thr Ile Ile Arg  Ile Phe Lys Arg His  Gly Ala Val 
    1040                 1045                 1050             


Gln Leu  Cys Thr Pro Leu Leu  Leu Pro Arg Asn Arg  Gln Ile Tyr 
    1055                 1060                 1065             


Glu His  Asn Glu Ala Ala Leu  Phe Met Asp His Ser  Gly Met Leu 
    1070                 1075                 1080             


Val Met  Leu Pro Phe Asp Leu  Arg Ile Pro Phe Ala  Arg Tyr Val 
    1085                 1090                 1095             


Ala Arg  Asn Asn Ile Leu Asn  Leu Lys Arg Tyr Cys  Ile Glu Arg 
    1100                 1105                 1110             


Val Phe  Arg Pro Arg Lys Leu  Asp Arg Phe His Pro  Lys Glu Leu 
    1115                 1120                 1125             


Leu Glu  Cys Ala Phe Asp Ile  Val Thr Ser Thr Thr  Asn Ser Phe 
    1130                 1135                 1140             


Leu Pro  Thr Ala Glu Ile Ile  Tyr Thr Ile Tyr Glu  Ile Ile Gln 
    1145                 1150                 1155             


Glu Phe  Pro Ala Leu Gln Glu  Arg Asn Tyr Ser Ile  Tyr Leu Asn 
    1160                 1165                 1170             


His Thr  Met Leu Leu Lys Ala  Ile Leu Leu His Cys  Gly Ile Pro 
    1175                 1180                 1185             


Glu Asp  Lys Leu Ser Gln Val  Tyr Ile Ile Leu Tyr  Asp Ala Val 
    1190                 1195                 1200             


Thr Glu  Lys Leu Thr Arg Arg  Glu Val Glu Ala Lys  Phe Cys Asn 
    1205                 1210                 1215             


Leu Ser  Leu Ser Ser Asn Ser  Leu Cys Arg Leu Tyr  Lys Phe Ile 
    1220                 1225                 1230             


Glu Gln  Lys Gly Asp Leu Gln  Asp Leu Met Pro Thr  Ile Asn Ser 
    1235                 1240                 1245             


Leu Ile  Lys Gln Lys Thr Gly  Ile Ala Gln Leu Val  Lys Tyr Gly 
    1250                 1255                 1260             


Leu Lys  Asp Leu Glu Glu Val  Val Gly Leu Leu Lys  Lys Leu Gly 
    1265                 1270                 1275             


Ile Lys  Leu Gln Val Leu Ile  Asn Leu Gly Leu Val  Tyr Lys Val 
    1280                 1285                 1290             


Gln Gln  His Asn Gly Ile Ile  Phe Gln Phe Val Ala  Phe Ile Lys 
    1295                 1300                 1305             


Arg Arg  Gln Arg Ala Val Pro  Glu Ile Leu Ala Ala  Gly Gly Arg 
    1310                 1315                 1320             


Tyr Asp  Leu Leu Ile Pro Gln  Phe Arg Gly Pro Gln  Ala Leu Gly 
    1325                 1330                 1335             


Pro Val  Pro Thr Ala Ile Gly  Val Ser Ile Ala Ile  Asp Lys Ile 
    1340                 1345                 1350             


Ser Ala  Ala Val Leu Asn Met  Glu Glu Ser Val Thr  Ile Ser Ser 
    1355                 1360                 1365             


Cys Asp  Leu Leu Val Val Ser  Val Gly Gln Met Ser  Met Ser Arg 
    1370                 1375                 1380             


Ala Ile  Asn Leu Thr Gln Lys  Leu Trp Thr Ala Gly  Ile Thr Ala 
    1385                 1390                 1395             


Glu Ile  Met Tyr Asp Trp Ser  Gln Ser Gln Glu Glu  Leu Gln Glu 
    1400                 1405                 1410             


Tyr Cys  Arg His His Glu Ile  Thr Tyr Val Ala Leu  Val Ser Asp 
    1415                 1420                 1425             


Lys Glu  Gly Ser His Val Lys  Val Lys Ser Phe Glu  Lys Glu Arg 
    1430                 1435                 1440             


Gln Thr  Glu Lys Arg Val Leu  Glu Thr Glu Leu Val  Asp His Val 
    1445                 1450                 1455             


Leu Gln  Lys Leu Arg Thr Lys  Val Thr Asp Glu Arg  Asn Gly Arg 
    1460                 1465                 1470             


Glu Ala  Ser Asp Asn Leu Ala  Val Gln Asn Leu Lys  Gly Ser Phe 
    1475                 1480                 1485             


Ser Asn  Ala Ser Gly Leu Phe  Glu Ile His Gly Ala  Thr Val Val 
    1490                 1495                 1500             


Pro Ile  Val Ser Val Leu Ala  Pro Glu Lys Leu Ser  Ala Ser Thr 
    1505                 1510                 1515             


Arg Arg  Arg Tyr Glu Thr Gln  Val Gln Thr Arg Leu  Gln Thr Ser 
    1520                 1525                 1530             


Leu Ala  Asn Leu His Gln Lys  Ser Ser Glu Ile Glu  Ile Leu Ala 
    1535                 1540                 1545             


Val Asp  Leu Pro Lys Glu Thr  Ile Leu Gln Phe Leu  Ser Leu Glu 
    1550                 1555                 1560             


Trp Asp  Ala Asp Glu Gln Ala  Phe Asn Thr Thr Val  Lys Gln Leu 
    1565                 1570                 1575             


Leu Ser  Arg Leu Pro Lys Gln  Arg Tyr Leu Lys Leu  Val Cys Asp 
    1580                 1585                 1590             


Glu Ile  Tyr Asn Ile Lys Val  Glu Lys Lys Val Ser  Val Leu Phe 
    1595                 1600                 1605             


Leu Tyr  Ser Tyr Arg Asp Asp  Tyr Tyr Arg Ile Leu  Phe 
    1610                 1615                 1620     


<210> 6687
<211> 795
<212> PRT
<213> Homo sapiens

<400> 6687
Met Lys Phe Thr Asn Thr Lys Val Gln Met Met Gln Asn Val His Leu 
1               5                   10                  15      


Ala Pro Glu Thr Asp Glu Asp Asp Leu Tyr Ser Gly Tyr Asn Asp Tyr 
            20                  25                  30          


Asn Pro Ile Tyr Asp Ile Glu Glu Leu Glu Asn Asp Ala Ala Phe Gln 
        35                  40                  45              


Gln Ala Val Arg Thr Ser His Gly Arg Arg Pro Pro Ile Thr Ala Lys 
    50                  55                  60                  


Ile Ser Ser Thr Ala Val Thr Arg Pro Ile Ala Thr Gly Tyr Gly Ser 
65                  70                  75                  80  


Lys Thr Ser Leu Ala Ser Ser Ile Gly Arg Pro Met Thr Gly Ala Ile 
                85                  90                  95      


Gln Asp Gly Val Thr Arg Pro Met Thr Ala Val Arg Ala Ala Gly Phe 
            100                 105                 110         


Thr Lys Ala Ala Leu Arg Gly Ser Ala Phe Asp Pro Leu Ser Gln Ser 
        115                 120                 125             


Arg Gly Pro Ala Ser Pro Leu Glu Ala Lys Lys Lys Asp Ser Pro Glu 
    130                 135                 140                 


Glu Lys Ile Lys Gln Leu Glu Lys Glu Val Asn Glu Leu Val Glu Glu 
145                 150                 155                 160 


Ser Cys Ile Ala Asn Ser Cys Gly Asp Leu Lys Leu Ala Leu Glu Lys 
                165                 170                 175     


Ala Lys Asp Ala Gly Arg Lys Glu Arg Val Leu Val Arg Gln Arg Glu 
            180                 185                 190         


Gln Val Thr Thr Pro Glu Asn Ile Asn Leu Asp Leu Thr Tyr Ser Val 
        195                 200                 205             


Leu Phe Asn Leu Ala Ser Gln Tyr Ser Val Asn Glu Met Tyr Ala Glu 
    210                 215                 220                 


Ala Leu Asn Thr Tyr Gln Val Ile Val Lys Asn Lys Met Phe Ser Asn 
225                 230                 235                 240 


Ala Gly Ile Leu Lys Met Asn Met Gly Asn Ile Tyr Leu Lys Gln Arg 
                245                 250                 255     


Asn Tyr Ser Lys Ala Ile Lys Phe Tyr Arg Met Ala Leu Asp Gln Val 
            260                 265                 270         


Pro Ser Val Asn Lys Gln Met Arg Ile Lys Ile Met Gln Asn Ile Gly 
        275                 280                 285             


Val Thr Phe Ile Gln Ala Gly Gln Tyr Ser Asp Ala Ile Asn Ser Tyr 
    290                 295                 300                 


Glu His Ile Met Ser Met Ala Pro Asn Leu Lys Ala Gly Tyr Asn Leu 
305                 310                 315                 320 


Thr Ile Cys Tyr Phe Ala Ile Gly Asp Arg Glu Lys Met Lys Lys Ala 
                325                 330                 335     


Phe Gln Lys Leu Ile Thr Val Pro Leu Glu Ile Asp Glu Asp Lys Tyr 
            340                 345                 350         


Ile Ser Pro Ser Asp Asp Pro His Thr Asn Leu Val Thr Glu Ala Ile 
        355                 360                 365             


Lys Asn Asp His Leu Arg Gln Met Glu Arg Glu Arg Lys Ala Met Ala 
    370                 375                 380                 


Glu Lys Tyr Ile Met Thr Ser Ala Lys Leu Ile Ala Pro Val Ile Glu 
385                 390                 395                 400 


Thr Ser Phe Ala Ala Gly Tyr Asp Trp Cys Val Glu Val Val Lys Ala 
                405                 410                 415     


Ser Gln Tyr Val Glu Leu Ala Asn Asp Leu Glu Ile Asn Lys Ala Val 
            420                 425                 430         


Thr Tyr Leu Arg Gln Lys Asp Tyr Asn Gln Ala Val Glu Ile Leu Lys 
        435                 440                 445             


Val Leu Glu Lys Lys Asp Ser Arg Val Lys Ser Ala Ala Ala Thr Asn 
    450                 455                 460                 


Leu Ser Ala Leu Tyr Tyr Met Gly Lys Asp Phe Ala Gln Ala Ser Ser 
465                 470                 475                 480 


Tyr Ala Asp Ile Ala Val Asn Ser Asp Arg Tyr Asn Pro Ala Ala Leu 
                485                 490                 495     


Thr Asn Lys Gly Asn Thr Val Phe Ala Asn Gly Asp Tyr Glu Lys Ala 
            500                 505                 510         


Ala Glu Phe Tyr Lys Glu Ala Leu Arg Asn Asp Ser Ser Cys Thr Glu 
        515                 520                 525             


Ala Leu Tyr Asn Ile Gly Leu Thr Tyr Glu Lys Leu Asn Arg Leu Asp 
    530                 535                 540                 


Glu Ala Leu Asp Cys Phe Leu Lys Leu His Ala Ile Leu Arg Asn Ser 
545                 550                 555                 560 


Ala Glu Val Leu Tyr Gln Ile Ala Asn Ile Tyr Glu Leu Met Glu Asn 
                565                 570                 575     


Pro Ser Gln Ala Ile Glu Trp Leu Met Gln Val Val Ser Val Ile Pro 
            580                 585                 590         


Thr Asp Pro Gln Val Leu Ser Lys Leu Gly Glu Leu Tyr Asp Arg Glu 
        595                 600                 605             


Gly Asp Lys Ser Gln Ala Phe Gln Tyr Tyr Tyr Glu Ser Tyr Arg Tyr 
    610                 615                 620                 


Phe Pro Cys Asn Ile Glu Val Ile Glu Trp Leu Gly Ala Tyr Tyr Ile 
625                 630                 635                 640 


Asp Thr Gln Phe Trp Glu Lys Ala Ile Gln Tyr Phe Glu Arg Ala Ser 
                645                 650                 655     


Leu Ile Gln Pro Thr Gln Val Lys Trp Gln Leu Met Val Ala Ser Cys 
            660                 665                 670         


Phe Arg Arg Ser Gly Asn Tyr Gln Lys Ala Leu Asp Thr Tyr Lys Asp 
        675                 680                 685             


Thr His Arg Lys Phe Pro Glu Asn Val Glu Cys Ser Gly Ser Val Arg 
    690                 695                 700                 


Thr Gly His Met Glu Arg Asp Pro Leu Asn Leu Leu Pro Arg Lys Ser 
705                 710                 715                 720 


Val Leu Pro Gly Pro Glu Ile Ala Lys Cys Asn Tyr Phe Ser Gly Glu 
                725                 730                 735     


Lys Tyr Tyr Leu Ser Ala Phe Leu Ser Ser Ser Leu His Arg Ser Trp 
            740                 745                 750         


Ile Lys Arg Cys Ser Arg Ile Cys Gln Lys Thr Glu Glu Val Gly Lys 
        755                 760                 765             


Asn Glu Arg Asn Lys Gly Thr Ala His Lys Val Arg Gln Arg Trp Gln 
    770                 775                 780                 


Trp Gly Leu Pro Trp Gln Lys Arg Arg Lys Cys 
785                 790                 795 


<210> 6688
<211> 63
<212> PRT
<213> Homo sapiens

<400> 6688
Met Ser Tyr Tyr Arg Ser Tyr Tyr Gly Gly Leu Gly Tyr Gly Tyr Gly 
1               5                   10                  15      


Gly Phe Gly Gly Trp Gly Tyr Gly Tyr Gly Cys Gly Tyr Gly Ser Phe 
            20                  25                  30          


Arg Arg Leu Gly Tyr Gly Cys Gly Tyr Gly Gly Tyr Gly Phe Ser Cys 
        35                  40                  45              


Cys Arg Pro Leu Tyr Tyr Gly Gly Tyr Gly Phe Ser Ala Phe Tyr 
    50                  55                  60              


<210> 6689
<211> 44
<212> PRT
<213> Homo sapiens

<400> 6689
Met Ser Tyr Tyr Gly Asn Tyr Tyr Gly Gly Leu Gly Tyr Gly Tyr Asp 
1               5                   10                  15      


Cys Lys Tyr Ser Tyr Thr Ser Gly Phe Gly Ala Phe Arg Ile Leu Asp 
            20                  25                  30          


Cys Gly Tyr Arg Cys Gly Cys Gly Gly Val Trp Ile 
        35                  40                  


<210> 6690
<211> 44
<212> PRT
<213> Homo sapiens

<400> 6690
Met Ser Tyr Tyr Ser His Leu Ser Gly Gly Leu Gly Cys Gly Leu Ala 
1               5                   10                  15      


Val Ala Val Thr Met Gly Arg Thr Val Ala Val Ala Glu Tyr Gly Arg 
            20                  25                  30          


Cys Arg His Gly Cys His Ser Ser Tyr Ser Ala Arg 
        35                  40                  


<210> 6691
<211> 45
<212> PRT
<213> Homo sapiens

<400> 6691
Met Cys Tyr Tyr His Asn Tyr Tyr Gly Ser Leu Asp Tyr Gly Cys Ser 
1               5                   10                  15      


Tyr Gly Ser Glu Tyr Gly Asn Ser Gly Tyr Ala Cys Asn Phe Pro Cys 
            20                  25                  30          


Ser Tyr Gly Arg Phe Leu Leu Ala Pro Arg Lys Lys Phe 
        35                  40                  45  


<210> 6692
<211> 207
<212> PRT
<213> Homo sapiens

<400> 6692
Met Pro His Ser His Cys His Ser Leu Arg Ser Phe His Asn Ala Pro 
1               5                   10                  15      


Pro Leu Ser Ala Ile Thr His Gly Thr Asn Pro Ile Thr Phe Glu Asp 
            20                  25                  30          


Arg Leu Cys Leu Pro Ser Ser Phe His Ser Arg Thr Cys Phe Leu Asp 
        35                  40                  45              


Asn Phe Gln Glu Thr Cys Asn Glu Thr Thr Ser Cys Gln Met Thr Asn 
    50                  55                  60                  


Cys Glu Gln Asp Leu Phe Thr Asp Asp Ser Cys Val Gln Ser Asn Cys 
65                  70                  75                  80  


Phe Pro Gly Val Val Gln Thr Thr Tyr Ser Asn Ser Arg Pro Cys Glu 
                85                  90                  95      


Arg Thr Ala Cys Gln Ser Glu Ser Ser Ser Ala Gly Leu Ala Cys Val 
            100                 105                 110         


Ser Gln Pro Cys Gln Ser Glu Ser Thr Gln Gln Met Gly Phe Val Ala 
        115                 120                 125             


Gln Ser Cys Gln Pro Ala Ser Leu Lys Gly Asn Ser Cys Pro Pro Lys 
    130                 135                 140                 


Thr Ser Lys Ser Lys Asn Phe Glu Thr Leu Glu Arg Ala Ser Ser Gln 
145                 150                 155                 160 


Cys Gln Cys Gln Ser Gln Asn Pro Glu Ser Ser Ser Cys Arg Pro Leu 
                165                 170                 175     


Val Asn Val Ala Pro Glu Pro Gln Leu Leu Glu Ser Ser Pro Gly Val 
            180                 185                 190         


Glu Pro Thr Cys Cys Val Thr Gly Gly Ser Gln Leu Pro Ser Lys 
        195                 200                 205         


<210> 6693
<211> 214
<212> PRT
<213> Homo sapiens

<400> 6693
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu His Val Phe Val 
                165                 170                 175     


Phe His His Ser Leu Phe Gly Ala Thr Phe Gly Glu His His Phe Gln 
            180                 185                 190         


Pro Cys Pro Leu Pro Ser Gly Asn Lys Ala Pro Ile Ser Thr Trp Ser 
        195                 200                 205             


Gly Asp Ser Trp Leu Leu 
    210                 


<210> 6694
<211> 214
<212> PRT
<213> Homo sapiens

<400> 6694
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu His Val Phe Val 
                165                 170                 175     


Phe His His Ser Leu Phe Gly Ala Thr Phe Gly Glu His His Phe Gln 
            180                 185                 190         


Pro Cys Pro Leu Pro Ser Gly Asn Lys Ala Pro Ile Ser Thr Trp Ser 
        195                 200                 205             


Gly Asp Ser Trp Leu Leu 
    210                 


<210> 6695
<211> 478
<212> PRT
<213> Homo sapiens

<400> 6695
Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His 
    130                 135                 140                 


Trp Gln Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala 
145                 150                 155                 160 


Ala Arg Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu 
                165                 170                 175     


Ile Arg Ala Arg Asn Pro Ala Phe Gln Pro Gln Thr Leu Met Asp Phe 
            180                 185                 190         


Gly Ser Gly Thr Gly Ser Val Thr Trp Ala Ala His Ser Ile Trp Gly 
        195                 200                 205             


Gln Ser Leu Arg Glu Tyr Met Cys Val Asp Arg Ser Ala Ala Met Leu 
    210                 215                 220                 


Val Leu Ala Glu Lys Leu Leu Lys Gly Gly Ser Glu Ser Gly Glu Pro 
225                 230                 235                 240 


Tyr Ile Pro Gly Val Phe Phe Arg Gln Phe Leu Pro Val Ser Pro Lys 
                245                 250                 255     


Val Gln Phe Asp Val Val Val Ser Ala Phe Ser Leu Ser Glu Leu Pro 
            260                 265                 270         


Ser Lys Ala Asp Arg Thr Glu Val Val Gln Thr Leu Trp Arg Lys Thr 
        275                 280                 285             


Gly His Phe Leu Val Leu Val Glu Asn Gly Thr Lys Ala Gly His Ser 
    290                 295                 300                 


Leu Leu Met Asp Ala Arg Asp Leu Val Leu Lys Gly Lys Glu Lys Ser 
305                 310                 315                 320 


Pro Leu Asp Pro Arg Pro Gly Phe Val Phe Ala Pro Cys Pro His Glu 
                325                 330                 335     


Leu Pro Cys Pro Gln Leu Thr Asn Leu Ala Cys Ser Phe Ser Gln Ala 
            340                 345                 350         


Tyr His Pro Ile Pro Phe Ser Trp Asn Lys Lys Pro Lys Glu Glu Lys 
        355                 360                 365             


Phe Ser Met Val Ile Leu Ala Arg Gly Ser Pro Glu Glu Ala His Arg 
    370                 375                 380                 


Trp Pro Arg Ile Thr Gln Pro Val Leu Lys Arg Pro Arg His Val His 
385                 390                 395                 400 


Cys His Leu Cys Cys Pro Asp Gly His Met Gln His Ala Val Leu Thr 
                405                 410                 415     


Ala Arg Arg His Gly Arg Tyr Gly Gly Cys Asp Gln Asn Gln Trp Asp 
            420                 425                 430         


Val Ala Gly Ser Cys Ser Pro Arg Gln His Leu Phe Pro Gln Gly Phe 
        435                 440                 445             


Val Ser Leu Cys Pro Cys Gln Leu Leu Gly Arg Ser Phe Thr Cys Ala 
    450                 455                 460                 


Tyr Ser Val Cys Val Ser Ser Ile Tyr Gly Ser Gly Ser Leu 
465                 470                 475             


<210> 6696
<211> 257
<212> PRT
<213> Homo sapiens

<400> 6696
Met Glu Glu Glu Ala Ser Ser Pro Gly Leu Gly Cys Ser Lys Pro His 
1               5                   10                  15      


Leu Glu Lys Leu Thr Leu Gly Ile Thr Arg Ile Leu Glu Ser Ser Pro 
            20                  25                  30          


Gly Val Thr Glu Val Thr Ile Ile Glu Lys Pro Pro Ala Glu Arg His 
        35                  40                  45              


Met Ile Ser Ser Trp Glu Gln Lys Asn Asn Cys Val Met Pro Glu Asp 
    50                  55                  60                  


Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His Met Thr Trp Ser 
65                  70                  75                  80  


Val Lys Leu Asp Ala Ser Asp Asp Gln Pro Glu Lys Pro His Phe Asp 
                85                  90                  95      


Ser Arg Ser Val Ile Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys 
            100                 105                 110         


Val Cys Leu Val Tyr Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr 
        115                 120                 125             


Glu Ile Trp Phe Leu Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp 
    130                 135                 140                 


Thr Phe Thr Ala Tyr Tyr Arg Leu Leu Ile Thr His Leu Gly Leu Pro 
145                 150                 155                 160 


Gln Trp Gln Tyr Ala Phe Thr Ser Tyr Gly Ile Ser Pro Gln Ala Lys 
                165                 170                 175     


Gln Trp Phe Ser Met Tyr Lys Pro Ile Thr Tyr Asn Thr Asn Leu Leu 
            180                 185                 190         


Thr Glu Glu Thr Asp Ser Phe Val Asn Lys Leu Asp Pro Ser Lys Val 
        195                 200                 205             


Phe Lys Ser Lys Asn Lys Ile Val Ile Pro Lys Lys Lys Gly Pro Val 
    210                 215                 220                 


Gln Pro Ala Gly Gly Gln Lys Gly Pro Ser Gly Pro Ser Gly Pro Ser 
225                 230                 235                 240 


Thr Ser Ser Thr Ser Lys Ser Ser Ser Gly Ser Gly Asn Pro Thr Arg 
                245                 250                 255     


Lys 
    


<210> 6697
<211> 263
<212> PRT
<213> Homo sapiens

<400> 6697
Met Leu Ser Ser Lys Gly Leu Thr Val Val Asp Val Tyr Gln Gly Trp 
1               5                   10                  15      


Cys Gly Pro Cys Lys Pro Val Val Ser Leu Phe Gln Lys Met Arg Ile 
            20                  25                  30          


Glu Val Gly Leu Asp Leu Leu His Phe Ala Leu Ala Glu Ala Asp Arg 
        35                  40                  45              


Leu Asp Val Leu Glu Lys Tyr Arg Gly Lys Cys Glu Pro Thr Phe Leu 
    50                  55                  60                  


Phe Tyr Ala Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val 
65                  70                  75                  80  


Ser His Gly Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu 
                85                  90                  95      


Arg Thr Cys Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly 
            100                 105                 110         


Lys Thr Asp Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile 
        115                 120                 125             


Leu Thr Asn Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe 
    130                 135                 140                 


Tyr Gln His Lys Ala Gly Glu Glu Ala Phe Glu Lys Leu Val His His 
145                 150                 155                 160 


Met Cys Ser Gly Pro Ser His Leu Leu Ile Leu Thr Arg Thr Glu Gly 
                165                 170                 175     


Phe Glu Asp Val Val Thr Thr Trp Arg Thr Val Met Gly Pro Arg Asp 
            180                 185                 190         


Pro Asn Val Ala Arg Arg Glu Gln Pro Glu Ser Leu Arg Ala Gln Tyr 
        195                 200                 205             


Gly Thr Glu Met Pro Phe Asn Ala Val His Gly Ser Arg Asp Arg Glu 
    210                 215                 220                 


Asp Ala Asp Arg Glu Leu Ala Leu Leu Phe Pro Ser Leu Lys Phe Ser 
225                 230                 235                 240 


Asp Lys Asp Thr Glu Ala Pro Gln Gly Glu Ser Ser Thr Gln Pro Arg 
                245                 250                 255     


Leu Lys Ile Thr Asp Leu Asp 
            260             


<210> 6698
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6698
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 6699
<211> 541
<212> PRT
<213> Homo sapiens

<400> 6699
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Thr Met Arg Val Asn Asp Leu Val Gly Thr 
225                 230                 235                 240 


Ser Met Thr Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Thr Asn Thr Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Arg Pro Arg Glu Glu Ser Leu Ala Glu Lys Lys 
305                 310                 315                 320 


Tyr Thr Ser Gln Gly Gln Gly Asp Leu Asp Ser Val Leu Ser Gln Leu 
                325                 330                 335     


Asn Phe Thr His Thr Ser Glu Asp Leu Leu Gln Ala Glu Val Thr Cys 
            340                 345                 350         


Leu Glu Gly Ser Leu Glu Ser Val Ser Ala Thr Cys Lys Gln Leu Ser 
        355                 360                 365             


Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu Ala His 
    370                 375                 380                 


Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln Ile Leu 
385                 390                 395                 400 


Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys Met Glu 
                405                 410                 415     


Ile Ser His Leu Thr Gln Glu Leu His Gln Arg Asp Ile Thr Ile Ala 
            420                 425                 430         


Ser Thr Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg Ala Glu 
        435                 440                 445             


Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile Leu Asp 
    450                 455                 460                 


Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu Met Val 
465                 470                 475                 480 


Met Lys Leu Glu Leu Gly Leu His Glu Cys Ser Leu Pro Val Ser Pro 
                485                 490                 495     


Leu Gly Ser Ile Ala Thr Arg Phe Leu Glu Glu Glu Glu Leu Arg Ser 
            500                 505                 510         


His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu Lys Arg 
        515                 520                 525             


Glu Ser Glu Lys Thr Val Arg Gln Phe Thr Ala Leu Lys 
    530                 535                 540     


<210> 6700
<211> 160
<212> PRT
<213> Homo sapiens

<400> 6700
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 6701
<211> 160
<212> PRT
<213> Homo sapiens

<400> 6701
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 6702
<211> 1063
<212> PRT
<213> Homo sapiens

<400> 6702
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 
                245                 250                 255     


Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 
            260                 265                 270         


Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 
        275                 280                 285             


Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 
    290                 295                 300                 


Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 
305                 310                 315                 320 


Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr 
                325                 330                 335     


Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro 
            340                 345                 350         


Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro 
        355                 360                 365             


Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro 
    370                 375                 380                 


His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala 
385                 390                 395                 400 


Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile 
                405                 410                 415     


Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly 
            420                 425                 430         


Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu 
        435                 440                 445             


Arg Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile 
    450                 455                 460                 


Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp 
465                 470                 475                 480 


Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu 
                485                 490                 495     


Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln 
            500                 505                 510         


His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp 
        515                 520                 525             


Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln 
    530                 535                 540                 


Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg 
545                 550                 555                 560 


Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu 
                565                 570                 575     


Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe 
            580                 585                 590         


Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg 
        595                 600                 605             


Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe 
    610                 615                 620                 


Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu 
625                 630                 635                 640 


Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly 
                645                 650                 655     


Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile 
            660                 665                 670         


Ile Ser Gly Val Glu Met Gln Leu Leu Gln Glu Lys Leu Arg Ser Gly 
        675                 680                 685             


Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys 
    690                 695                 700                 


Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe 
705                 710                 715                 720 


Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val 
                725                 730                 735     


Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala 
            740                 745                 750         


Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro 
        755                 760                 765             


Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser 
    770                 775                 780                 


Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg 
785                 790                 795                 800 


Glu Leu Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn 
                805                 810                 815     


Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser 
            820                 825                 830         


Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu 
        835                 840                 845             


Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu 
    850                 855                 860                 


Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile 
865                 870                 875                 880 


Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln 
                885                 890                 895     


Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val 
            900                 905                 910         


Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg 
        915                 920                 925             


Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala 
    930                 935                 940                 


Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu 
945                 950                 955                 960 


Leu Pro Pro Gly Thr Ala Ala Pro Ser Gly Trp Ala Gln Ala Pro Leu 
                965                 970                 975     


Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly Leu Val Asp Pro 
            980                 985                 990         


Gln Ile Gln Leu Pro Leu Leu Ala  Ala Arg Arg Tyr Lys  Leu Gln Lys 
        995                 1000                 1005             


Gln Leu  Asp Ser Leu Thr Ala  Arg Thr Pro Ser Glu  Gly Glu Ala 
    1010                 1015                 1020             


Gly Thr  Gln Arg Gln Gln Lys  Leu Ser Ser Leu Gln  Leu Glu Leu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Lys Ala Ala  Ser His Leu Arg Gln  Leu Met Asp 
    1040                 1045                 1050             


Glu Pro  Pro Ala Pro Gly Ser  Pro Glu Leu 
    1055                 1060             


<210> 6703
<211> 539
<212> PRT
<213> Homo sapiens

<400> 6703
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 6704
<211> 225
<212> PRT
<213> Homo sapiens

<400> 6704
Met Ala Ala Gly Ser Glu Ala Thr Thr Pro Val Ile Val Ala Ala Gly 
1               5                   10                  15      


Ala Gly Gly Glu Glu Gly Glu His Val Lys Pro Phe Lys Pro Glu Lys 
            20                  25                  30          


Ala Lys Glu Ile Ile Met Ser Leu Gln Gln Pro Ala Ile Phe Cys Asn 
        35                  40                  45              


Met Val Phe Asp Trp Pro Ala Arg His Trp Asn Ala Lys Tyr Leu Ser 
    50                  55                  60                  


Gln Val Leu His Gly Lys Gln Ile Arg Phe Arg Met Gly Met Lys Ser 
65                  70                  75                  80  


Met Ser Thr Val Pro Gln Phe Glu Thr Thr Cys Asn Tyr Val Glu Ala 
                85                  90                  95      


Thr Leu Glu Glu Phe Leu Thr Trp Asn Cys Asp Gln Ser Ser Ile Ser 
            100                 105                 110         


Gly Pro Phe Arg Asp Tyr Asp His Ser Lys Phe Trp Ala Tyr Ala Asp 
        115                 120                 125             


Tyr Lys Tyr Phe Val Ser Leu Phe Glu Asp Lys Thr Asp Leu Phe Gln 
    130                 135                 140                 


Asp Val Lys Trp Ser Asp Phe Gly Phe Pro Gly Arg Asn Gly Gln Glu 
145                 150                 155                 160 


Ser Thr Leu Trp Ile Gly Ser Leu Gly Ala His Thr Pro Cys His Leu 
                165                 170                 175     


Asp Ser Tyr Gly Cys Asn Leu Val Phe Gln Val Gln Gly Arg Leu Glu 
            180                 185                 190         


Cys Asn Gly Met Ile Ile Ala Pro Gly Pro Gln Ala Ile Leu Leu Pro 
        195                 200                 205             


Gln Pro Leu Lys Tyr Leu Gly Leu Gln Glu Thr Met Ala Ser Leu Ser 
    210                 215                 220                 


Ser 
225 


<210> 6705
<211> 856
<212> PRT
<213> Homo sapiens

<400> 6705
Met Asp Ile Ser Lys Gly Leu Pro Gly Met Gln Gly Gly Leu His Ile 
1               5                   10                  15      


Trp Ile Ser Glu Asn Arg Lys Met Val Pro Val Pro Glu Gly Ala Tyr 
            20                  25                  30          


Gly Asn Phe Phe Glu Glu His Cys Tyr Val Ile Leu His Val Pro Gln 
        35                  40                  45              


Ser Pro Lys Ala Thr Gln Gly Ala Ser Ser Asp Leu His Tyr Trp Val 
    50                  55                  60                  


Gly Lys Gln Ala Gly Ala Glu Ala Gln Gly Ala Ala Glu Ala Phe Gln 
65                  70                  75                  80  


Gln Arg Leu Gln Asp Glu Leu Gly Gly Gln Thr Val Leu His Arg Glu 
                85                  90                  95      


Ala Gln Gly His Glu Ser Asp Cys Phe Cys Ser Tyr Phe Arg Pro Gly 
            100                 105                 110         


Ile Ile Tyr Arg Lys Gly Gly Leu Ala Ser Asp Leu Lys His Val Glu 
        115                 120                 125             


Thr Asn Leu Phe Asn Ile Gln Arg Leu Leu His Ile Lys Gly Arg Lys 
    130                 135                 140                 


His Val Ser Ala Thr Glu Val Glu Leu Ser Trp Asn Ser Phe Asn Lys 
145                 150                 155                 160 


Gly Asp Ile Phe Leu Leu Asp Leu Gly Lys Met Met Ile Gln Trp Asn 
                165                 170                 175     


Gly Pro Lys Thr Ser Ile Ser Glu Lys Ala Arg Gly Leu Ala Leu Thr 
            180                 185                 190         


Tyr Ser Leu Arg Asp Arg Glu Arg Gly Gly Gly Arg Ala Gln Ile Gly 
        195                 200                 205             


Val Val Asp Asp Glu Ala Lys Ala Pro Asp Leu Met Gln Ile Met Glu 
    210                 215                 220                 


Ala Val Leu Gly Arg Arg Val Gly Ser Leu Arg Ala Ala Thr Pro Ser 
225                 230                 235                 240 


Lys Asp Ile Asn Gln Leu Gln Lys Ala Asn Val Arg Leu Tyr His Val 
                245                 250                 255     


Tyr Glu Lys Gly Lys Asp Leu Val Val Leu Glu Leu Ala Thr Pro Pro 
            260                 265                 270         


Leu Thr Gln Asp Leu Leu Gln Glu Glu Asp Phe Tyr Ile Leu Asp Gln 
        275                 280                 285             


Gly Gly Phe Lys Ile Tyr Val Trp Gln Gly Arg Met Ser Ser Leu Gln 
    290                 295                 300                 


Glu Arg Lys Ala Ala Phe Ser Arg Ala Val Gly Phe Ile Gln Ala Lys 
305                 310                 315                 320 


Gly Tyr Pro Thr Tyr Thr Asn Val Glu Val Val Asn Asp Gly Ala Glu 
                325                 330                 335     


Ser Ala Ala Phe Lys Gln Leu Phe Arg Thr Trp Ser Glu Lys Arg Arg 
            340                 345                 350         


Arg Asn Gln Lys Leu Gly Gly Arg Asp Lys Ser Ile His Val Lys Leu 
        355                 360                 365             


Asp Val Gly Lys Leu His Thr Gln Pro Lys Leu Ala Ala Gln Leu Arg 
    370                 375                 380                 


Met Val Asp Asp Gly Ser Gly Lys Val Glu Val Trp Cys Ile Gln Asp 
385                 390                 395                 400 


Leu His Arg Gln Pro Val Asp Pro Lys Arg His Gly Gln Leu Cys Ala 
                405                 410                 415     


Gly Asn Cys Tyr Leu Val Leu Tyr Thr Tyr Gln Arg Leu Gly Arg Val 
            420                 425                 430         


Gln Tyr Ile Leu Tyr Leu Trp Gln Gly His Gln Ala Thr Ala Asp Glu 
        435                 440                 445             


Ile Glu Ala Leu Asn Ser Asn Ala Glu Glu Leu Asp Val Met Tyr Gly 
    450                 455                 460                 


Gly Val Leu Val Gln Glu His Val Thr Met Gly Ser Glu Pro Pro His 
465                 470                 475                 480 


Phe Leu Ala Ile Phe Gln Gly Gln Leu Val Ile Phe Gln Glu Arg Ala 
                485                 490                 495     


Gly His His Gly Lys Gly Gln Ser Ala Ser Thr Thr Arg Leu Phe Gln 
            500                 505                 510         


Val Gln Gly Thr Asp Ser His Asn Thr Arg Thr Met Glu Val Pro Ala 
        515                 520                 525             


Arg Ala Ser Ser Leu Asn Ser Ser Asp Ile Phe Leu Leu Val Thr Ala 
    530                 535                 540                 


Ser Val Cys Tyr Leu Trp Phe Gly Lys Gly Cys Asn Gly Asp Gln Arg 
545                 550                 555                 560 


Glu Met Ala Arg Val Val Val Thr Val Ile Ser Arg Lys Asn Glu Glu 
                565                 570                 575     


Thr Val Leu Glu Gly Gln Glu Pro Pro His Phe Trp Glu Ala Leu Gly 
            580                 585                 590         


Gly Arg Ala Pro Tyr Pro Ser Asn Lys Arg Leu Pro Glu Glu Val Pro 
        595                 600                 605             


Ser Phe Gln Pro Arg Leu Phe Glu Cys Ser Ser His Met Gly Cys Leu 
    610                 615                 620                 


Val Leu Ala Glu Val Gly Phe Phe Ser Gln Glu Asp Leu Asp Lys Tyr 
625                 630                 635                 640 


Asp Ile Met Leu Leu Asp Thr Trp Gln Glu Ile Phe Leu Trp Leu Gly 
                645                 650                 655     


Glu Ala Ala Ser Glu Trp Lys Glu Ala Val Ala Trp Gly Gln Glu Tyr 
            660                 665                 670         


Leu Lys Thr His Pro Ala Gly Arg Ser Pro Ala Thr Pro Ile Val Leu 
        675                 680                 685             


Val Lys Gln Gly His Glu Pro Pro Thr Phe Ile Gly Trp Phe Phe Thr 
    690                 695                 700                 


Trp Asp Pro Tyr Lys Trp Thr Ser His Pro Ser His Lys Glu Val Val 
705                 710                 715                 720 


Asp Gly Ser Pro Ala Ala Ala Ser Thr Ile Ser Glu Ile Thr Ala Glu 
                725                 730                 735     


Val Asn Asn Leu Arg Leu Ser Arg Trp Pro Gly Asn Gly Arg Ala Gly 
            740                 745                 750         


Ala Val Ala Leu Gln Ala Leu Lys Gly Ser Gln Asp Ser Ser Glu Asn 
        755                 760                 765             


Asp Leu Val Arg Ser Pro Lys Ser Ala Gly Ser Arg Thr Ser Ser Ser 
    770                 775                 780                 


Val Ser Ser Thr Ser Ala Thr Ile Asn Gly Gly Leu Arg Arg Glu Gln 
785                 790                 795                 800 


Leu Met His Gln Ala Val Glu Asp Leu Pro Glu Gly Val Asp Pro Ala 
                805                 810                 815     


Arg Arg Glu Phe Tyr Leu Ser Asp Ser Asp Phe Gln Asp Ile Phe Gly 
            820                 825                 830         


Lys Ser Lys Glu Glu Phe Tyr Ser Met Ala Thr Trp Arg Gln Arg Gln 
        835                 840                 845             


Glu Lys Lys Gln Leu Gly Phe Phe 
    850                 855     


<210> 6706
<211> 868
<212> PRT
<213> Homo sapiens

<400> 6706
Met Ala Ser Phe Pro Glu Thr Asp Phe Gln Ile Cys Leu Leu Cys Lys 
1               5                   10                  15      


Glu Met Cys Gly Ser Pro Ala Pro Leu Ser Ser Asn Ser Ser Ala Ser 
            20                  25                  30          


Ser Ser Ser Ser Gln Thr Ser Thr Ser Ser Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Ala Ala Ala Arg Arg Leu His Val Leu Pro Cys Leu His Ala 
    50                  55                  60                  


Phe Cys Arg Pro Cys Leu Glu Ala His Arg Leu Pro Ala Ala Gly Gly 
65                  70                  75                  80  


Gly Ala Ala Gly Glu Pro Leu Lys Leu Arg Cys Pro Val Cys Asp Gln 
                85                  90                  95      


Lys Val Val Leu Ala Glu Ala Ala Gly Met Asp Ala Leu Pro Ser Ser 
            100                 105                 110         


Ala Phe Leu Leu Ser Asn Leu Leu Asp Ala Val Val Ala Thr Ala Asp 
        115                 120                 125             


Glu Pro Pro Pro Lys Asn Gly Arg Ala Gly Ala Pro Ala Gly Ala Gly 
    130                 135                 140                 


Gly His Ser Asn His Arg His His Ala His His Ala His Pro Arg Ala 
145                 150                 155                 160 


Ser Ala Ser Ala Pro Pro Leu Pro Gln Ala Pro Gln Pro Pro Ala Pro 
                165                 170                 175     


Ser Arg Ser Ala Pro Gly Gly Pro Ala Ala Ser Pro Ser Ala Leu Leu 
            180                 185                 190         


Leu Arg Arg Pro His Gly Cys Ser Ser Cys Asp Glu Gly Asn Ala Ala 
        195                 200                 205             


Ser Ser Arg Cys Leu Asp Cys Gln Glu His Leu Cys Asp Asn Cys Val 
    210                 215                 220                 


Arg Ala His Gln Arg Val Arg Leu Thr Lys Asp His Tyr Ile Glu Arg 
225                 230                 235                 240 


Gly Pro Pro Gly Pro Gly Ala Ala Ala Ala Ala Gln Gln Leu Gly Leu 
                245                 250                 255     


Gly Pro Pro Phe Pro Gly Pro Pro Phe Ser Ile Leu Ser Val Phe Pro 
            260                 265                 270         


Glu Arg Leu Gly Phe Cys Gln His His Asp Asp Glu Val Leu His Leu 
        275                 280                 285             


Tyr Cys Asp Thr Cys Ser Val Pro Ile Cys Arg Glu Cys Thr Met Gly 
    290                 295                 300                 


Arg His Gly Gly His Ser Phe Ile Tyr Leu Gln Glu Ala Leu Gln Asp 
305                 310                 315                 320 


Ser Arg Ala Leu Thr Ile Gln Leu Leu Ala Asp Ala Gln Gln Gly Arg 
                325                 330                 335     


Gln Ala Ile Gln Leu Ser Ile Glu Gln Ala Gln Thr Val Ala Glu Gln 
            340                 345                 350         


Val Glu Met Lys Ala Lys Val Val Gln Ser Glu Val Lys Ala Val Thr 
        355                 360                 365             


Ala Arg His Lys Lys Ala Leu Glu Glu Arg Glu Cys Glu Leu Leu Trp 
    370                 375                 380                 


Lys Val Glu Lys Ile Arg Gln Val Lys Ala Lys Ser Leu Tyr Leu Gln 
385                 390                 395                 400 


Val Glu Lys Leu Arg Gln Asn Leu Asn Lys Leu Glu Ser Thr Ile Ser 
                405                 410                 415     


Ala Val Gln Gln Val Leu Glu Glu Gly Arg Ala Leu Asp Ile Leu Leu 
            420                 425                 430         


Ala Arg Asp Arg Met Leu Ala Gln Val Gln Glu Leu Lys Thr Val Arg 
        435                 440                 445             


Ser Leu Leu Gln Pro Gln Glu Asp Asp Arg Val Met Phe Thr Pro Pro 
    450                 455                 460                 


Asp Gln Ala Leu Tyr Leu Ala Ile Lys Ser Phe Gly Phe Val Ser Ser 
465                 470                 475                 480 


Gly Ala Phe Ala Pro Leu Thr Lys Ala Thr Gly Asp Gly Leu Lys Arg 
                485                 490                 495     


Ala Leu Gln Gly Lys Val Ala Ser Phe Thr Val Ile Gly Tyr Asp His 
            500                 505                 510         


Asp Gly Glu Pro Arg Leu Ser Gly Gly Asp Leu Met Ser Ala Val Val 
        515                 520                 525             


Leu Gly Pro Asp Gly Asn Leu Phe Gly Ala Glu Val Ser Asp Gln Gln 
    530                 535                 540                 


Asn Gly Thr Tyr Val Val Ser Tyr Arg Pro Gln Leu Glu Gly Glu His 
545                 550                 555                 560 


Leu Val Ser Val Thr Leu Cys Asn Gln His Ile Glu Asn Ser Pro Phe 
                565                 570                 575     


Lys Val Val Val Lys Ser Gly Arg Ser Tyr Val Gly Ile Gly Leu Pro 
            580                 585                 590         


Gly Leu Ser Phe Gly Ser Glu Gly Asp Ser Asp Gly Lys Leu Cys Arg 
        595                 600                 605             


Pro Trp Gly Val Ser Val Asp Lys Glu Gly Tyr Ile Ile Val Ala Asp 
    610                 615                 620                 


Arg Ser Asn Asn Arg Ile Gln Val Phe Lys Pro Cys Gly Ala Phe His 
625                 630                 635                 640 


His Lys Phe Gly Thr Leu Gly Ser Arg Pro Gly Gln Phe Asp Arg Pro 
                645                 650                 655     


Ala Gly Val Ala Cys Asp Ala Ser Arg Arg Ile Val Val Ala Asp Lys 
            660                 665                 670         


Asp Asn His Arg Ile Gln Ile Phe Thr Phe Glu Gly Gln Phe Leu Leu 
        675                 680                 685             


Lys Phe Gly Glu Lys Gly Thr Lys Asn Gly Gln Phe Asn Tyr Pro Trp 
    690                 695                 700                 


Asp Val Ala Val Asn Ser Glu Gly Lys Ile Leu Val Ser Asp Thr Arg 
705                 710                 715                 720 


Asn His Arg Ile Gln Leu Phe Gly Pro Asp Gly Val Phe Leu Asn Lys 
                725                 730                 735     


Tyr Gly Phe Glu Gly Ala Leu Trp Lys His Phe Asp Ser Pro Arg Gly 
            740                 745                 750         


Val Ala Phe Asn His Glu Gly His Leu Val Val Thr Asp Phe Asn Asn 
        755                 760                 765             


His Arg Leu Leu Val Ile His Pro Asp Cys Gln Ser Ala Arg Phe Leu 
    770                 775                 780                 


Gly Ser Glu Gly Thr Gly Asn Gly Gln Phe Leu Arg Pro Gln Gly Val 
785                 790                 795                 800 


Ala Val Asp Gln Glu Gly Arg Ile Ile Val Ala Asp Ser Arg Asn His 
                805                 810                 815     


Arg Val Gln Met Phe Glu Ser Asn Gly Ser Phe Leu Cys Lys Phe Gly 
            820                 825                 830         


Ala Gln Gly Ser Gly Phe Gly Gln Met Asp Arg Pro Ser Gly Ile Ala 
        835                 840                 845             


Ile Thr Pro Asp Gly Met Ile Val Val Val Asp Phe Gly Asn Asn Arg 
    850                 855                 860                 


Ile Leu Val Phe 
865             


<210> 6707
<211> 368
<212> PRT
<213> Homo sapiens

<400> 6707
Met Arg Glu Pro Val Leu Thr Trp Cys Val Pro Leu Glu Leu Leu Cys 
1               5                   10                  15      


Ser His Pro Leu Pro Leu Ser Ala Phe Leu Lys Ser Gln Val Lys Leu 
            20                  25                  30          


Tyr Thr Tyr Arg Ala Cys Ala Gly Lys Asp Glu Met Gly Lys Met Val 
        35                  40                  45              


Ser Val Ile Asn Thr Val Asp Thr Ser His Glu Asp Met Ile His Asp 
    50                  55                  60                  


Ala Gln Met Asp Tyr Tyr Gly Thr Arg Leu Ala Thr Cys Ser Ser Asp 
65                  70                  75                  80  


Arg Ser Val Lys Ile Phe Asp Val Arg Asn Gly Gly Gln Ile Leu Ile 
                85                  90                  95      


Ala Asp Leu Arg Gly His Glu Gly Pro Val Trp Gln Val Ala Trp Ala 
            100                 105                 110         


His Pro Met Tyr Gly Asn Ile Leu Ala Ser Cys Ser Tyr Asp Arg Lys 
        115                 120                 125             


Val Ile Ile Trp Arg Glu Glu Asn Gly Thr Trp Glu Lys Ser His Glu 
    130                 135                 140                 


His Ala Gly His Asp Ser Ser Val Asn Ser Val Cys Trp Ala Pro His 
145                 150                 155                 160 


Asp Tyr Gly Leu Ile Leu Ala Cys Gly Ser Ser Asp Gly Ala Ile Ser 
                165                 170                 175     


Leu Leu Thr Tyr Thr Gly Glu Gly Gln Trp Glu Val Lys Lys Ile Asn 
            180                 185                 190         


Asn Ala His Thr Ile Gly Cys Asn Ala Val Ser Trp Ala Pro Ala Val 
        195                 200                 205             


Val Pro Gly Ser Leu Ile Asp His Pro Ser Gly Gln Lys Pro Asn Tyr 
    210                 215                 220                 


Ile Lys Arg Phe Ala Ser Gly Gly Cys Asp Asn Leu Ile Lys Leu Trp 
225                 230                 235                 240 


Lys Glu Glu Glu Asp Gly Gln Trp Lys Glu Glu Gln Lys Leu Glu Ala 
                245                 250                 255     


His Ser Asp Trp Val Arg Asp Val Ala Trp Ala Pro Ser Ile Gly Leu 
            260                 265                 270         


Pro Thr Ser Thr Ile Ala Ser Cys Ser Gln Asp Gly Arg Val Phe Ile 
        275                 280                 285             


Trp Thr Cys Asp Asp Ala Ser Ser Asn Thr Trp Ser Pro Lys Leu Leu 
    290                 295                 300                 


His Lys Phe Asn Asp Val Val Trp His Val Ser Trp Ser Ile Thr Ala 
305                 310                 315                 320 


Asn Ile Leu Ala Val Ser Gly Gly Asp Asn Lys Val Thr Leu Trp Lys 
                325                 330                 335     


Glu Ser Val Asp Gly Gln Trp Val Cys Ile Ser Asp Val Asn Lys Gly 
            340                 345                 350         


Gln Gly Ser Val Ser Ala Ser Val Thr Glu Gly Gln Gln Asn Glu Gln 
        355                 360                 365             


<210> 6708
<211> 352
<212> PRT
<213> Homo sapiens

<400> 6708
Met Asp Ile Asp Lys Asp Leu Glu Ala Pro Leu Tyr Leu Thr Pro Glu 
1               5                   10                  15      


Gly Trp Ser Leu Phe Leu Gln Arg Tyr Tyr Gln Val Val His Glu Gly 
            20                  25                  30          


Ala Glu Leu Arg His Leu Asp Thr Gln Val Gln Arg Cys Glu Asp Ile 
        35                  40                  45              


Leu Gln Gln Leu Gln Ala Val Val Pro Gln Ile Asp Met Glu Gly Asp 
    50                  55                  60                  


Arg Asn Ile Trp Ile Val Lys Pro Gly Ala Lys Ser Arg Gly Arg Gly 
65                  70                  75                  80  


Ile Met Cys Met Asp His Leu Glu Glu Met Leu Lys Leu Val Asn Gly 
                85                  90                  95      


Asn Pro Val Val Met Lys Asp Gly Lys Trp Val Val Gln Lys Tyr Ile 
            100                 105                 110         


Glu Arg Pro Leu Leu Ile Phe Gly Thr Lys Phe Asp Leu Arg Gln Trp 
        115                 120                 125             


Phe Leu Val Thr Asp Trp Asn Pro Leu Thr Val Trp Phe Tyr Arg Asp 
    130                 135                 140                 


Ser Tyr Ile Arg Phe Ser Thr Gln Pro Phe Ser Leu Lys Asn Leu Asp 
145                 150                 155                 160 


Asn Ser Val His Leu Cys Asn Asn Ser Ile Gln Lys His Leu Glu Asn 
                165                 170                 175     


Ser Cys His Arg His Pro Leu Leu Pro Pro Asp Asn Met Trp Ser Ser 
            180                 185                 190         


Gln Arg Phe Gln Ala His Leu Gln Glu Met Gly Ala Pro Asn Ala Trp 
        195                 200                 205             


Ser Thr Ile Ile Val Pro Gly Met Lys Asp Ala Val Ile His Ala Leu 
    210                 215                 220                 


Gln Thr Ser Gln Asp Thr Val Gln Cys Arg Lys Ala Ser Phe Glu Leu 
225                 230                 235                 240 


Tyr Gly Ala Asp Phe Val Phe Gly Glu Asp Phe Gln Pro Trp Leu Ile 
                245                 250                 255     


Glu Ile Asn Ala Ser Pro Thr Met Ala Pro Ser Thr Ala Val Thr Ala 
            260                 265                 270         


Arg Leu Cys Ala Gly Val Gln Ala Asp Thr Leu Arg Val Val Ile Asp 
        275                 280                 285             


Arg Met Leu Asp Arg Asn Cys Asp Thr Gly Ala Phe Glu Leu Ile Tyr 
    290                 295                 300                 


Lys Gln Pro Val Thr Thr Ser Pro Ala Ser Thr Pro Arg Pro Ser Cys 
305                 310                 315                 320 


Leu Leu Pro Met Tyr Ser Asp Thr Arg Ala Arg Ser Ser Asp Asp Ser 
                325                 330                 335     


Thr Ala Ser Trp Trp Ala Leu Arg Pro Cys Arg Pro Gln Ala Arg Pro 
            340                 345                 350         


<210> 6709
<211> 192
<212> PRT
<213> Homo sapiens

<400> 6709
Met Gly Lys Gly Cys Lys Val Val Val Cys Gly Leu Leu Ser Val Gly 
1               5                   10                  15      


Lys Thr Ala Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Thr Ile Gly 
            20                  25                  30          


Met Glu Asp Cys Glu Thr Met Glu Asp Val Tyr Met Ala Ser Val Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Lys Glu Gln Leu His Leu Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Gln Glu Gly Val Glu Leu Pro Lys His Tyr Phe Ser Phe Ala Asp 
65                  70                  75                  80  


Gly Phe Val Leu Val Tyr Ser Val Asn Asn Leu Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Phe Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Ala Ile Val Val Leu Gly Asn Lys Ile Asp Leu Ser Glu Gln Arg 
        115                 120                 125             


Gln Val Asp Ala Glu Val Ala Gln Gln Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Arg Leu Trp Glu Val Thr Val Thr Asp Arg Lys Thr Leu Ile Glu Pro 
145                 150                 155                 160 


Phe Thr Leu Leu Ala Ser Lys Leu Ser Gln Pro Gln Ser Lys Ser Ser 
                165                 170                 175     


Phe Pro Leu Pro Gly Arg Lys Asn Lys Gly Asn Ser Asn Ser Glu Asn 
            180                 185                 190         


<210> 6710
<211> 472
<212> PRT
<213> Homo sapiens

<400> 6710
Met Ser Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Ala Ala Lys Ala Asp Gln Ala Tyr Glu Asp Ile Arg Val Ser Lys 
            20                  25                  30          


Val Thr Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Lys Phe Leu Ala 
        35                  40                  45              


Ile Ile Val Glu Ala Gly Gly Gly Gly Ala Phe Ile Val Leu Pro Leu 
    50                  55                  60                  


Ala Lys Thr Gly Arg Val Asp Lys Asn Tyr Pro Leu Val Thr Gly His 
65                  70                  75                  80  


Thr Ala Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Ala Ser Asp Asp Thr Thr Ile Met Val Trp Gln Ile Pro 
            100                 105                 110         


Asp Tyr Thr Pro Met Arg Asn Ile Thr Glu Pro Ile Ile Thr Leu Glu 
        115                 120                 125             


Gly His Ser Lys Arg Val Gly Ile Leu Ser Trp His Pro Thr Ala Arg 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Gly Asp Asn Val Ile Ile Ile Trp Asn 
145                 150                 155                 160 


Val Gly Thr Gly Glu Val Leu Leu Ser Leu Asp Asp Met His Pro Asp 
                165                 170                 175     


Val Ile His Ser Val Cys Trp Asn Ser Asn Gly Ser Leu Leu Ala Thr 
            180                 185                 190         


Thr Cys Lys Asp Lys Thr Leu Arg Ile Ile Asp Pro Arg Lys Gly Gln 
        195                 200                 205             


Val Val Ala Glu Arg Phe Ala Ala His Glu Gly Met Arg Pro Met Arg 
    210                 215                 220                 


Ala Val Phe Thr Arg Gln Gly His Ile Phe Thr Thr Gly Phe Thr Arg 
225                 230                 235                 240 


Met Ser Gln Arg Glu Leu Gly Leu Trp Asp Pro Asn Asn Phe Glu Glu 
                245                 250                 255     


Pro Val Ala Leu Gln Glu Met Asp Thr Ser Asn Gly Val Leu Leu Pro 
            260                 265                 270         


Phe Tyr Asp Pro Asp Ser Ser Ile Val Tyr Leu Cys Gly Lys Gly Asp 
        275                 280                 285             


Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp Glu Pro Pro Phe Val His 
    290                 295                 300                 


Tyr Leu Asn Thr Phe Ser Ser Lys Glu Pro Gln Arg Gly Met Gly Phe 
305                 310                 315                 320 


Met Pro Lys Arg Gly Leu Asp Val Ser Lys Cys Glu Ile Ala Arg Phe 
                325                 330                 335     


Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Ile Met Thr Val Pro 
            340                 345                 350         


Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Pro Gly 
        355                 360                 365             


Pro Glu Pro Ala Leu Glu Ala Asp Glu Trp Leu Ser Gly Gln Asp Ala 
    370                 375                 380                 


Glu Pro Val Leu Ile Ser Leu Arg Asp Gly Tyr Val Pro Pro Lys His 
385                 390                 395                 400 


Arg Glu Leu Arg Val Thr Lys Arg Asn Ile Leu Asp Val Arg Pro Pro 
                405                 410                 415     


Ser Gly Pro Arg Arg Ser Gln Ser Ala Ser Asp Ala Pro Leu Ser Gln 
            420                 425                 430         


Gln His Thr Leu Glu Thr Leu Leu Glu Glu Ile Lys Ala Leu Arg Glu 
        435                 440                 445             


Arg Val Gln Ala Gln Glu Gln Arg Ile Thr Ala Leu Glu Asn Met Leu 
    450                 455                 460                 


Cys Glu Leu Val Asp Gly Thr Asp 
465                 470         


<210> 6711
<211> 875
<212> PRT
<213> Homo sapiens

<400> 6711
Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe 
1               5                   10                  15      


Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg 
            20                  25                  30          


Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu 
        35                  40                  45              


Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu 
    50                  55                  60                  


Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met 
65                  70                  75                  80  


Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr 
                85                  90                  95      


Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro 
            100                 105                 110         


Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu 
        115                 120                 125             


Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val 
    130                 135                 140                 


Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp 
145                 150                 155                 160 


Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys 
                165                 170                 175     


Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys 
            180                 185                 190         


Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys 
        195                 200                 205             


Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe 
    210                 215                 220                 


Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile 
225                 230                 235                 240 


Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys 
                245                 250                 255     


Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu 
            260                 265                 270         


Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu 
        275                 280                 285             


Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp 
    290                 295                 300                 


Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser 
305                 310                 315                 320 


Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu 
                325                 330                 335     


Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg 
            340                 345                 350         


Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser 
        355                 360                 365             


Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu 
    370                 375                 380                 


Glu Ala Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu Trp 
385                 390                 395                 400 


Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro Leu 
                405                 410                 415     


His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile Ser 
            420                 425                 430         


Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met Arg 
        435                 440                 445             


Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg Gly 
    450                 455                 460                 


Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp Asn 
465                 470                 475                 480 


Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val Asn 
                485                 490                 495     


Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln His 
            500                 505                 510         


Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile His 
        515                 520                 525             


Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr Pro 
    530                 535                 540                 


Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn Ile 
545                 550                 555                 560 


Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu Leu 
                565                 570                 575     


Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly Asn 
            580                 585                 590         


Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val Leu 
        595                 600                 605             


Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr Tyr 
    610                 615                 620                 


Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys Gly 
625                 630                 635                 640 


Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His Gly 
                645                 650                 655     


Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro Leu 
            660                 665                 670         


Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met Gly 
        675                 680                 685             


Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn Thr 
    690                 695                 700                 


Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys Lys 
705                 710                 715                 720 


Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His Ala 
                725                 730                 735     


Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn Phe 
            740                 745                 750         


Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala Gln 
        755                 760                 765             


Pro Pro Gly Pro Ala Gln Ile Leu Pro Pro Gly Leu Thr Pro Gly Leu 
    770                 775                 780                 


Pro Tyr Pro His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln Pro 
785                 790                 795                 800 


Arg Pro Pro Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val 
                805                 810                 815     


Pro Thr Gly Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg 
            820                 825                 830         


Gly Asn Tyr Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys Pro 
        835                 840                 845             


Arg Asn Arg Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr Arg 
    850                 855                 860                 


Asp Leu Asp Ala Pro Asp Asp Val Asp Phe Phe 
865                 870                 875 


<210> 6712
<211> 271
<212> PRT
<213> Homo sapiens

<400> 6712
Met Ala Ala Val Glu Lys Arg Arg Gln Ala Val Pro Pro Pro Ala Gly 
1               5                   10                  15      


Phe Thr Asp Ser Gly Arg Gln Ser Val Ser Arg Ala Ala Gly Ala Ala 
            20                  25                  30          


Glu Ser Glu Glu Asp Phe Leu Arg Gln Val Gly Val Thr Glu Met Leu 
        35                  40                  45              


Arg Ala Ala Leu Leu Lys Val Leu Glu Ala Arg Pro Glu Glu Pro Ile 
    50                  55                  60                  


Ala Phe Leu Ala His Tyr Phe Glu Asn Met Gly Leu Arg Ser Pro Val 
65                  70                  75                  80  


Asn Gly Gly Ala Gly Glu Pro Pro Gly Gln Leu Leu Leu Gln Gln Gln 
                85                  90                  95      


Arg Leu Gly Arg Ala Leu Trp His Leu Arg Leu Ala His His Ser Gln 
            100                 105                 110         


Arg Ala Ala Phe Asn Asn Asn Val Ser Val Ala Tyr Glu Cys Leu Ser 
        115                 120                 125             


Ala Gly Gly Arg Arg Lys Arg Pro Gly Leu Asp Gly Arg Thr Tyr Ser 
    130                 135                 140                 


Glu Leu Leu Arg Arg Ile Cys Arg Asp Gly Gln Ala Pro Glu Glu Val 
145                 150                 155                 160 


Val Ala Pro Leu Leu Arg Lys Val Gln Cys Arg Asp His Glu Ala Val 
                165                 170                 175     


Pro Leu Ser Val Phe Arg Ala Gly Thr Leu Thr Cys Phe Val Leu Leu 
            180                 185                 190         


Glu Phe Val Ala Arg Ala Gly Ala Leu Phe Gln Leu Leu Glu Asp Ser 
        195                 200                 205             


Ala Ala Ala Val Ala Asp Arg Arg Val Gly Gln Ala Val Leu Asp Thr 
    210                 215                 220                 


Leu Glu Gly Ala Leu Gln Ala Ser Asp Ala Ala Ala Pro Ala Arg Phe 
225                 230                 235                 240 


Leu Glu Ala Gly Ser Arg Leu Ala Pro Met Thr Arg Glu Glu Phe Leu 
                245                 250                 255     


Glu Arg Ala Ala Ala Leu Phe Ile Ala Lys Val Lys Pro Val Gly 
            260                 265                 270     


<210> 6713
<211> 658
<212> PRT
<213> Homo sapiens

<400> 6713
Met Gly Gly His Leu Ser Pro Trp Pro Thr Tyr Thr Ser Gly Gln Thr 
1               5                   10                  15      


Ile Leu Gln Asn Arg Lys Pro Cys Ser Asp Asp Tyr Arg Lys Arg Val 
            20                  25                  30          


Gly Ser Cys Gln Gln His Pro Phe Arg Thr Ala Lys Pro Gln Tyr Leu 
        35                  40                  45              


Glu Glu Leu Glu Asn Tyr Leu Arg Lys Glu Leu Leu Leu Leu Asp Leu 
    50                  55                  60                  


Gly Thr Asp Ser Thr Gln Glu Leu Arg Leu Gln Pro Tyr Arg Glu Ile 
65                  70                  75                  80  


Phe Glu Phe Phe Ile Glu Asp Phe Lys Thr Tyr Lys Pro Leu Leu Ser 
                85                  90                  95      


Ser Ile Lys Asn Ala Tyr Glu Gly Met Leu Ala His Gln Arg Glu Lys 
            100                 105                 110         


Ile Arg Ala Leu Glu Pro Leu Lys Ala Lys Leu Val Thr Val Asn Glu 
        115                 120                 125             


Asp Cys Asn Glu Arg Ile Leu Ala Met Arg Ala Glu Glu Lys Tyr Glu 
    130                 135                 140                 


Ile Ser Leu Leu Lys Lys Glu Lys Met Asn Leu Leu Lys Leu Ile Asp 
145                 150                 155                 160 


Lys Lys Asn Glu Glu Lys Ile Ser Leu Gln Ser Glu Val Thr Lys Leu 
                165                 170                 175     


Arg Lys Asn Leu Ala Glu Glu Tyr Leu His Tyr Leu Ser Glu Arg Asp 
            180                 185                 190         


Ala Cys Lys Ile Leu Ile Ala Asp Leu Asn Glu Leu Arg Tyr Gln Arg 
        195                 200                 205             


Glu Asp Met Ser Leu Ala Gln Ser Pro Gly Ile Trp Gly Glu Asp Pro 
    210                 215                 220                 


Val Lys Leu Thr Leu Ala Leu Lys Met Thr Arg Gln Asp Leu Thr Arg 
225                 230                 235                 240 


Thr Gln Met Glu Leu Asn Asn Met Lys Ala Asn Phe Gly Asp Val Val 
                245                 250                 255     


Pro Arg Arg Asp Phe Glu Met Gln Glu Lys Thr Asn Lys Asp Leu Gln 
            260                 265                 270         


Glu Gln Leu Asp Thr Leu Arg Ala Ser Tyr Glu Glu Val Arg Lys Glu 
        275                 280                 285             


His Glu Ile Leu Met Gln Leu His Met Ser Thr Leu Lys Glu Arg Asp 
    290                 295                 300                 


Gln Phe Phe Ser Glu Leu Gln Glu Ile Gln Arg Thr Ser Thr Pro Arg 
305                 310                 315                 320 


Pro Asp Trp Thr Lys Cys Lys Asp Val Val Ala Gly Gly Pro Glu Arg 
                325                 330                 335     


Trp Gln Met Leu Ala Glu Gly Lys Asn Ser Asp Gln Leu Val Asp Val 
            340                 345                 350         


Leu Leu Glu Glu Ile Gly Ser Gly Leu Leu Arg Glu Lys Asp Phe Phe 
        355                 360                 365             


Pro Gly Leu Gly Tyr Gly Glu Ala Ile Pro Ala Phe Leu Arg Phe Asp 
    370                 375                 380                 


Gly Leu Val Glu Asn Lys Lys Pro Ser Lys Lys Asp Val Val Asn Leu 
385                 390                 395                 400 


Leu Lys Asp Ala Trp Lys Glu Arg Leu Ala Glu Glu Gln Lys Glu Thr 
                405                 410                 415     


Phe Pro Asp Phe Phe Phe Asn Phe Leu Glu His Arg Phe Gly Pro Ser 
            420                 425                 430         


Asp Ala Met Ala Trp Ala Tyr Thr Ile Phe Glu Asn Ile Lys Ile Phe 
        435                 440                 445             


His Ser Asn Glu Val Met Ser Gln Phe Tyr Ala Val Leu Met Gly Lys 
    450                 455                 460                 


Arg Ser Glu Asn Val Tyr Val Thr Gln Lys Glu Thr Val Ala Gln Leu 
465                 470                 475                 480 


Leu Lys Glu Met Thr Asn Ala Asp Ser Gln Asn Glu Gly Leu Leu Thr 
                485                 490                 495     


Met Glu Gln Phe Asn Thr Val Leu Lys Ser Thr Phe Pro Leu Lys Thr 
            500                 505                 510         


Glu Glu Gln Ile Gln Glu Leu Met Glu Ala Gly Gly Trp His Pro Ser 
        515                 520                 525             


Ser Ser Asn Ala Asp Leu Leu Asn Tyr Arg Ser Leu Phe Met Glu Asp 
    530                 535                 540                 


Glu Glu Gly Gln Ser Glu Pro Phe Val Gln Lys Leu Trp Glu Gln Tyr 
545                 550                 555                 560 


Met Asp Glu Lys Asp Glu Tyr Leu Gln Gln Leu Lys Gln Glu Leu Gly 
                565                 570                 575     


Ile Glu Leu His Glu Glu Val Thr Leu Pro Lys Leu Arg Gly Gly Leu 
            580                 585                 590         


Met Thr Ile Asp Pro Ser Leu Asp Lys Gln Thr Val Asn Thr Tyr Met 
        595                 600                 605             


Ser Gln Ala Phe Gln Leu Pro Glu Ser Glu Met Pro Glu Glu Gly Asp 
    610                 615                 620                 


Glu Lys Glu Glu Ala Val Val Glu Ile Leu Gln Thr Ala Leu Glu Arg 
625                 630                 635                 640 


Leu Gln Val Ile Asp Ile Arg Arg Val Gly Pro Arg Glu Pro Glu Pro 
                645                 650                 655     


Ala Ser 
        


<210> 6714
<211> 428
<212> PRT
<213> Homo sapiens

<400> 6714
Met Glu Pro Leu Lys Val Glu Lys Phe Ala Thr Ala Lys Arg Gly Asn 
1               5                   10                  15      


Gly Leu Arg Ala Val Thr Pro Leu Arg Pro Gly Glu Leu Leu Phe Arg 
            20                  25                  30          


Ser Asp Pro Leu Ala Tyr Thr Val Cys Lys Gly Ser Arg Gly Val Val 
        35                  40                  45              


Cys Asp Arg Cys Leu Leu Gly Lys Glu Lys Leu Met Arg Cys Ser Gln 
    50                  55                  60                  


Cys Arg Val Ala Lys Tyr Cys Ser Ala Lys Cys Gln Lys Lys Ala Trp 
65                  70                  75                  80  


Pro Asp His Lys Arg Glu Cys Lys Cys Leu Lys Ser Cys Lys Pro Arg 
                85                  90                  95      


Tyr Pro Pro Asp Ser Val Arg Leu Leu Gly Arg Val Val Phe Lys Leu 
            100                 105                 110         


Met Asp Gly Ala Pro Ser Glu Ser Glu Lys Leu Tyr Ser Phe Tyr Asp 
        115                 120                 125             


Leu Glu Ser Asn Ile Asn Lys Leu Thr Glu Asp Lys Lys Glu Gly Leu 
    130                 135                 140                 


Arg Gln Leu Val Met Thr Phe Gln His Phe Met Arg Glu Glu Ile Gln 
145                 150                 155                 160 


Asp Ala Ser Gln Leu Pro Pro Ala Phe Asp Leu Phe Glu Ala Phe Ala 
                165                 170                 175     


Lys Val Ile Cys Asn Ser Phe Thr Ile Cys Asn Ala Glu Met Gln Glu 
            180                 185                 190         


Val Gly Val Gly Leu Tyr Pro Ser Ile Ser Leu Leu Asn His Ser Cys 
        195                 200                 205             


Asp Pro Asn Cys Ser Ile Val Phe Asn Gly Pro His Leu Leu Leu Arg 
    210                 215                 220                 


Ala Val Arg Asp Ile Glu Val Gly Glu Glu Leu Thr Ile Cys Tyr Leu 
225                 230                 235                 240 


Asp Met Leu Met Thr Ser Glu Glu Arg Arg Lys Gln Leu Arg Asp Gln 
                245                 250                 255     


Tyr Cys Phe Glu Cys Asp Cys Phe Arg Cys Gln Thr Gln Asp Lys Asp 
            260                 265                 270         


Ala Asp Met Leu Thr Gly Asp Glu Gln Val Trp Lys Glu Val Gln Glu 
        275                 280                 285             


Ser Leu Lys Lys Ile Glu Glu Leu Lys Ala His Trp Lys Trp Glu Gln 
    290                 295                 300                 


Val Leu Ala Met Cys Gln Ala Ile Ile Ser Ser Asn Ser Glu Arg Leu 
305                 310                 315                 320 


Pro Asp Ile Asn Ile Tyr Gln Leu Lys Val Leu Asp Cys Ala Met Asp 
                325                 330                 335     


Ala Cys Ile Asn Leu Gly Leu Leu Glu Glu Ala Leu Phe Tyr Gly Thr 
            340                 345                 350         


Arg Thr Met Glu Pro Tyr Arg Ile Phe Phe Pro Gly Ser His Pro Val 
        355                 360                 365             


Arg Gly Val Gln Val Met Lys Val Gly Lys Leu Gln Leu His Gln Gly 
    370                 375                 380                 


Met Phe Pro Gln Ala Met Lys Asn Leu Arg Leu Ala Phe Asp Ile Met 
385                 390                 395                 400 


Arg Val Thr His Gly Arg Glu His Ser Leu Ile Glu Asp Leu Ile Leu 
                405                 410                 415     


Leu Leu Glu Glu Cys Asp Ala Asn Ile Arg Ala Ser 
            420                 425             


<210> 6715
<211> 373
<212> PRT
<213> Homo sapiens

<400> 6715
Met Ser Ser Gly Asn Tyr Gln Gln Ser Glu Ala Leu Ser Lys Pro Thr 
1               5                   10                  15      


Phe Ser Glu Glu Gln Ala Ser Ala Leu Val Glu Ser Val Phe Gly Leu 
            20                  25                  30          


Lys Val Ser Lys Val Arg Pro Leu Pro Ser Tyr Asp Asp Gln Asn Phe 
        35                  40                  45              


His Val Tyr Val Ser Lys Thr Lys Asp Gly Pro Thr Glu Tyr Val Leu 
    50                  55                  60                  


Lys Ile Ser Asn Thr Lys Ala Ser Lys Asn Pro Asp Leu Ile Glu Val 
65                  70                  75                  80  


Gln Asn His Ile Ile Met Phe Leu Lys Ala Ala Gly Phe Pro Thr Ala 
                85                  90                  95      


Ser Val Cys His Thr Lys Gly Asp Asn Thr Ala Ser Leu Val Ser Val 
            100                 105                 110         


Asp Ser Gly Ser Glu Ile Lys Ser Tyr Leu Val Arg Leu Leu Thr Tyr 
        115                 120                 125             


Leu Pro Gly Arg Pro Ile Ala Glu Leu Pro Val Ser Pro Gln Leu Leu 
    130                 135                 140                 


Tyr Glu Ile Gly Lys Leu Ala Ala Lys Leu Asp Lys Thr Leu Gln Arg 
145                 150                 155                 160 


Phe His His Pro Lys Leu Ser Ser Leu His Arg Glu Asn Phe Ile Trp 
                165                 170                 175     


Asn Leu Lys Asn Val Pro Leu Leu Glu Lys Tyr Leu Tyr Ala Leu Gly 
            180                 185                 190         


Gln Asn Arg Asn Arg Glu Ile Val Glu His Val Ile His Leu Phe Lys 
        195                 200                 205             


Glu Glu Val Met Thr Lys Leu Ser His Phe Arg Glu Cys Ile Asn His 
    210                 215                 220                 


Gly Asp Leu Asn Asp His Asn Ile Leu Ile Glu Ser Ser Lys Ser Ala 
225                 230                 235                 240 


Ser Gly Asn Ala Glu Tyr Gln Val Ser Gly Ile Leu Asp Phe Gly Asp 
                245                 250                 255     


Met Ser Tyr Gly Tyr Tyr Val Phe Glu Val Ala Ile Thr Ile Met Tyr 
            260                 265                 270         


Met Met Ile Glu Ser Lys Ser Pro Ile Gln Val Gly Gly His Val Leu 
        275                 280                 285             


Ala Gly Phe Glu Ser Ile Thr Pro Leu Thr Ala Val Glu Lys Gly Ala 
    290                 295                 300                 


Leu Phe Leu Leu Val Cys Ser Arg Phe Cys Gln Ser Leu Val Met Ala 
305                 310                 315                 320 


Ala Tyr Ser Cys Gln Leu Tyr Pro Glu Asn Lys Asp Tyr Leu Met Val 
                325                 330                 335     


Thr Ala Lys Thr Gly Trp Lys His Leu Gln Gln Met Phe Asp Met Gly 
            340                 345                 350         


Gln Lys Ala Val Glu Glu Ile Trp Phe Glu Thr Ala Lys Ser Tyr Glu 
        355                 360                 365             


Ser Gly Ile Ser Met 
    370             


<210> 6716
<211> 921
<212> PRT
<213> Homo sapiens

<400> 6716
Met Ala Leu Leu Cys Gly Leu Gly Gln Val Thr Leu Arg Ile Trp Val 
1               5                   10                  15      


Ser Leu Pro Ser Gln Ser Glu Asn Gly Ile Gly Ser Gly Gly Met Glu 
            20                  25                  30          


Ala Leu Thr Thr Gln Leu Gly Pro Gly Arg Glu Gly Ser Ser Ser Pro 
        35                  40                  45              


Asn Ser Lys Gln Glu Leu Gln Pro Tyr Ser Gly Ser Ser Ala Leu Lys 
    50                  55                  60                  


Pro Asn Gln Val Gly Glu Thr Ser Leu Tyr Gly Val Pro Ile Val Ser 
65                  70                  75                  80  


Leu Val Ile Asp Gly Gln Glu Arg Leu Cys Leu Ala Gln Ile Ser Asn 
                85                  90                  95      


Thr Leu Leu Lys Asn Tyr Ser Tyr Asn Glu Ile His Asn Arg Arg Val 
            100                 105                 110         


Ala Leu Gly Ile Thr Cys Val Gln Cys Thr Pro Val Gln Leu Glu Ile 
        115                 120                 125             


Leu Arg Arg Ala Gly Ala Met Pro Ile Ser Ser Arg Arg Cys Gly Met 
    130                 135                 140                 


Ile Thr Lys Arg Glu Ala Glu Arg Leu Cys Lys Ser Phe Leu Gly Glu 
145                 150                 155                 160 


His Lys Pro Pro Lys Leu Pro Glu Asn Phe Ala Phe Asp Val Val His 
                165                 170                 175     


Glu Cys Ala Trp Gly Ser Arg Gly Ser Phe Ile Pro Ala Arg Tyr Asn 
            180                 185                 190         


Ser Ser Arg Ala Lys Cys Ile Lys Cys Gly Tyr Cys Ser Met Tyr Phe 
        195                 200                 205             


Ser Pro Asn Lys Phe Ile Phe His Ser His Arg Thr Pro Asp Ala Lys 
    210                 215                 220                 


Tyr Thr Gln Pro Asp Ala Ala Asn Phe Asn Ser Trp Arg Arg His Leu 
225                 230                 235                 240 


Lys Leu Ser Asp Lys Ser Ala Thr Asp Glu Leu Ser His Ala Trp Glu 
                245                 250                 255     


Asp Val Lys Ala Met Phe Asn Gly Gly Thr Arg Cys Gly Ala Glu Met 
            260                 265                 270         


Ala Pro Gly Pro Pro Pro His Lys Ser Leu Arg Cys Gly Glu Asp Glu 
        275                 280                 285             


Ala Ala Gly Pro Pro Gly Pro Pro Pro Pro His Pro Gln Arg Gly Leu 
    290                 295                 300                 


Gly Leu Ala Thr Gly Ala Ser Gly Pro Ala Gly Pro Gly Gly Pro Gly 
305                 310                 315                 320 


Gly Gly Ala Gly Val Arg Ser Tyr Pro Val Ile Pro Val Pro Ser Lys 
                325                 330                 335     


Gly Phe Gly Leu Leu Gln Lys Leu Pro Pro Pro Leu Phe Pro His Pro 
            340                 345                 350         


Tyr Gly Phe Pro Thr Ala Phe Gly Leu Cys Pro Lys Lys Asp Asp Pro 
        355                 360                 365             


Val Leu Gly Ala Gly Glu Pro Lys Gly Gly Pro Gly Thr Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ala Gly Thr Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser 
385                 390                 395                 400 


His Leu Pro Pro Gly Ala Gly Ala Gly Pro Gly Gly Gly Ala Met Phe 
                405                 410                 415     


Trp Gly His Gln Pro Ser Gly Ala Ala Lys Asp Ala Ala Ala Val Ala 
            420                 425                 430         


Ala Ala Ala Ala Ala Ala Thr Val Tyr Pro Thr Phe Pro Met Phe Trp 
        435                 440                 445             


Pro Ala Ala Gly Ser Leu Pro Val Pro Ser Tyr Pro Ala Ala Gln Ser 
    450                 455                 460                 


Gln Ala Lys Ala Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Gly Ser Gly Ala Pro Glu Pro Leu Asp Gly Ala Glu 
                485                 490                 495     


Pro Ala Lys Glu Ser Gly Leu Gly Ala Glu Glu Arg Cys Pro Ser Ala 
            500                 505                 510         


Leu Ser Arg Gly Pro Leu Asp Glu Asp Gly Thr Asp Glu Ala Leu Pro 
        515                 520                 525             


Pro Pro Leu Ala Pro Leu Pro Pro Pro Pro Pro Pro Pro Ala Arg Lys 
    530                 535                 540                 


Gly Ser Tyr Val Ser Ala Phe Arg Pro Val Val Lys Asp Thr Glu Ser 
545                 550                 555                 560 


Ile Ala Lys Leu Tyr Gly Ser Ala Arg Glu Ala Tyr Gly Ala Gly Pro 
                565                 570                 575     


Ala Arg Gly Pro Gly Pro Gly Ala Gly Ser Gly Gly Tyr Val Ser Pro 
            580                 585                 590         


Asp Phe Leu Ser Glu Gly Ser Ser Ser Tyr Asn Ser Ala Ser Pro Asp 
        595                 600                 605             


Val Asp Thr Ala Asp Glu Pro Glu Val Asp Val Glu Ser Asn Arg Phe 
    610                 615                 620                 


Pro Asp Asp Glu Asp Ala Gln Glu Glu Thr Glu Pro Ser Ala Pro Ser 
625                 630                 635                 640 


Ala Gly Gly Gly Pro Asp Gly Glu Gln Pro Thr Gly Pro Pro Ser Ala 
                645                 650                 655     


Thr Ser Ser Gly Ala Asp Gly Pro Ala Asn Ser Pro Asp Gly Gly Ser 
            660                 665                 670         


Pro Arg Pro Arg Arg Arg Leu Gly Pro Pro Pro Ala Gly Arg Pro Ala 
        675                 680                 685             


Phe Gly Asp Leu Ala Ala Glu Asp Leu Val Arg Arg Pro Glu Arg Ser 
    690                 695                 700                 


Pro Pro Ser Gly Gly Gly Gly Tyr Glu Leu Arg Glu Pro Cys Gly Pro 
705                 710                 715                 720 


Leu Gly Gly Pro Ala Pro Ala Lys Val Phe Ala Pro Glu Arg Asp Glu 
                725                 730                 735     


His Val Lys Ser Ala Ala Val Ala Leu Gly Pro Ala Ala Ser Tyr Val 
            740                 745                 750         


Cys Thr Pro Glu Ala His Glu Pro Asp Lys Glu Asp Asn His Ser Pro 
        755                 760                 765             


Ala Asp Asp Leu Glu Thr Arg Lys Ser Tyr Pro Asp Gln Arg Ser Ile 
    770                 775                 780                 


Ser Gln Pro Ser Pro Ala Asn Thr Asp Arg Gly Glu Asp Gly Leu Thr 
785                 790                 795                 800 


Leu Asp Val Thr Gly Thr His Leu Val Glu Lys Asp Ile Glu Asn Leu 
                805                 810                 815     


Ala Arg Glu Glu Leu Gln Lys Leu Leu Leu Glu Gln Met Glu Leu Arg 
            820                 825                 830         


Lys Lys Leu Glu Arg Glu Phe Gln Ser Leu Lys Asp Asn Phe Gln Asp 
        835                 840                 845             


Gln Met Lys Arg Glu Leu Ala Tyr Arg Glu Glu Met Val Gln Gln Leu 
    850                 855                 860                 


Gln Ile Val Arg Asp Thr Leu Cys Asn Glu Leu Asp Gln Glu Arg Lys 
865                 870                 875                 880 


Ala Arg Tyr Ala Ile Gln Gln Lys Leu Lys Glu Ala His Asp Ala Leu 
                885                 890                 895     


His His Phe Ser Cys Lys Met Leu Thr Pro Arg His Cys Thr Gly Asn 
            900                 905                 910         


Cys Ser Phe Lys Pro Pro Leu Leu Pro 
        915                 920     


<210> 6717
<211> 464
<212> PRT
<213> Homo sapiens

<400> 6717
Met Ala Met Thr Ala Gly Thr Thr Thr Thr Phe Pro Met Ser Asn His 
1               5                   10                  15      


Thr Arg Glu Arg Val Thr Val Ala Lys Leu Thr Leu Glu Asn Phe Tyr 
            20                  25                  30          


Ser Asn Leu Ile Leu Gln His Glu Glu Arg Glu Thr Arg Gln Lys Lys 
        35                  40                  45              


Leu Glu Val Ala Met Glu Glu Glu Gly Leu Ala Asp Glu Glu Lys Lys 
    50                  55                  60                  


Leu Arg Arg Ser Gln His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Arg Leu Gly Leu Asp Asp Phe Glu Ser Leu Lys Val Ile 
                85                  90                  95      


Gly Arg Gly Ala Phe Gly Glu Val Arg Leu Val Gln Lys Lys Asp Thr 
            100                 105                 110         


Gly His Ile Tyr Ala Met Lys Ile Leu Arg Lys Ser Asp Met Leu Glu 
        115                 120                 125             


Lys Glu Gln Val Ala His Ile Arg Ala Glu Arg Asp Ile Leu Val Glu 
    130                 135                 140                 


Ala Asp Gly Ala Trp Val Val Lys Met Phe Tyr Ser Phe Gln Asp Lys 
145                 150                 155                 160 


Arg Asn Leu Tyr Leu Ile Met Glu Phe Leu Pro Gly Gly Asp Met Met 
                165                 170                 175     


Thr Leu Leu Met Lys Lys Asp Thr Leu Thr Glu Glu Glu Thr Gln Phe 
            180                 185                 190         


Tyr Ile Ser Glu Thr Val Leu Ala Ile Asp Ala Ile His Gln Leu Gly 
        195                 200                 205             


Phe Ile His Arg Asp Ile Lys Pro Asp Asn Leu Leu Leu Asp Ala Lys 
    210                 215                 220                 


Gly His Val Lys Leu Ser Asp Phe Gly Leu Cys Thr Gly Leu Lys Lys 
225                 230                 235                 240 


Ala His Arg Thr Glu Phe Tyr Arg Asn Leu Thr His Asn Pro Pro Ser 
                245                 250                 255     


Asp Phe Ser Phe Gln Asn Met Asn Ser Lys Arg Lys Ala Glu Thr Trp 
            260                 265                 270         


Lys Lys Asn Arg Arg Gln Leu Ala Tyr Ser Thr Val Gly Thr Pro Asp 
        275                 280                 285             


Tyr Ile Ala Pro Glu Val Phe Met Gln Thr Gly Tyr Asn Lys Leu Cys 
    290                 295                 300                 


Asp Trp Trp Ser Leu Gly Val Ile Met Tyr Glu Met Leu Ile Gly Tyr 
305                 310                 315                 320 


Pro Pro Phe Cys Ser Glu Thr Pro Gln Glu Thr Tyr Arg Lys Val Met 
                325                 330                 335     


Asn Trp Lys Glu Thr Leu Val Phe Pro Pro Glu Val Pro Ile Ser Glu 
            340                 345                 350         


Lys Ala Lys Asp Leu Ile Leu Arg Phe Cys Ile Asp Ser Glu Asn Arg 
        355                 360                 365             


Ile Gly Asn Ser Gly Val Glu Glu Ile Lys Gly His Pro Phe Phe Glu 
    370                 375                 380                 


Gly Val Asp Trp Glu His Ile Arg Glu Arg Pro Ala Ala Ile Pro Ile 
385                 390                 395                 400 


Glu Ile Lys Ser Ile Asp Asp Thr Ser Asn Phe Asp Asp Phe Pro Glu 
                405                 410                 415     


Ser Asp Ile Leu Gln Pro Val Pro Asn Thr Thr Glu Pro Asp Tyr Lys 
            420                 425                 430         


Ser Lys Asp Trp Val Phe Leu Asn Tyr Thr Tyr Lys Arg Phe Glu Gly 
        435                 440                 445             


Leu Thr Gln Arg Gly Ser Ile Pro Thr Tyr Met Lys Ala Gly Lys Leu 
    450                 455                 460                 


<210> 6718
<211> 1316
<212> PRT
<213> Homo sapiens

<400> 6718
Met Ala Ser Lys Gly Ala Gly Met Ser Phe Ser Arg Lys Ser Tyr Arg 
1               5                   10                  15      


Leu Thr Ser Asp Ala Glu Lys Ser Arg Val Thr Gly Ile Val Gln Glu 
            20                  25                  30          


Lys Leu Leu Asn Asp Tyr Leu Asn Arg Ile Phe Ser Ser Ser Glu His 
        35                  40                  45              


Ala Pro Pro Ala Ala Thr Ser Arg Lys Pro Leu Asn Phe Gln Asn Leu 
    50                  55                  60                  


Pro Glu His Leu Asp Gln Leu Leu Gln Val Asp Asn Glu Glu Glu Glu 
65                  70                  75                  80  


Ser Gln Gly Gln Val Glu Gly Arg Leu Gly Pro Ser Thr Val Val Leu 
                85                  90                  95      


Asp His Thr Gly Gly Phe Glu Gly Leu Leu Leu Val Asp Asp Asp Leu 
            100                 105                 110         


Leu Gly Val Ile Gly His Ser Asn Phe Gly Thr Ile Arg Ser Thr Thr 
        115                 120                 125             


Cys Val Tyr Lys Gly Lys Trp Leu Tyr Glu Val Leu Ile Ser Ser Gln 
    130                 135                 140                 


Gly Leu Met Gln Ile Gly Trp Cys Thr Ile Ser Cys Arg Phe Asn Gln 
145                 150                 155                 160 


Glu Glu Gly Val Gly Asp Thr His Asn Ser Tyr Ala Tyr Asp Gly Asn 
                165                 170                 175     


Arg Val Arg Lys Trp Asn Val Thr Thr Thr Asn Tyr Gly Lys Ala Trp 
            180                 185                 190         


Ala Ala Gly Asp Ile Val Ser Cys Leu Ile Asp Leu Asp Asp Gly Thr 
        195                 200                 205             


Leu Ser Phe Cys Leu Asn Gly Val Ser Leu Gly Thr Ala Phe Glu Asn 
    210                 215                 220                 


Leu Ser Arg Gly Leu Gly Met Ala Tyr Phe Pro Ala Ile Ser Leu Ser 
225                 230                 235                 240 


Phe Lys Glu Ser Val Ala Phe Asn Phe Gly Ser Arg Pro Leu Arg Tyr 
                245                 250                 255     


Pro Val Ala Gly Tyr Arg Pro Leu Gln Asp Pro Pro Ser Ala Asp Leu 
            260                 265                 270         


Val Arg Ala Gln Arg Leu Leu Gly Cys Phe Arg Ala Val Leu Ser Val 
        275                 280                 285             


Glu Leu Asp Pro Val Glu Gly Arg Leu Leu Asp Lys Glu Ser Ser Lys 
    290                 295                 300                 


Trp Arg Leu Arg Gly Gln Pro Thr Val Leu Leu Thr Leu Ala His Ile 
305                 310                 315                 320 


Phe His His Phe Ala Pro Leu Leu Arg Lys Val Tyr Leu Val Glu Ala 
                325                 330                 335     


Val Leu Met Ser Phe Leu Leu Gly Ile Val Glu Lys Gly Thr Pro Thr 
            340                 345                 350         


Gln Ala Gln Ser Val Val His Gln Val Leu Asp Leu Leu Trp Leu Phe 
        355                 360                 365             


Met Glu Asp Tyr Glu Val Gln Asp Cys Leu Lys Gln Leu Met Met Ser 
    370                 375                 380                 


Leu Leu Arg Leu Tyr Arg Phe Ser Pro Ile Val Pro Asp Leu Gly Leu 
385                 390                 395                 400 


Gln Ile His Tyr Leu Arg Leu Thr Ile Ala Ile Leu Arg His Glu Lys 
                405                 410                 415     


Ser Arg Lys Phe Leu Leu Ser Asn Val Leu Phe Asp Val Leu Arg Ser 
            420                 425                 430         


Val Val Phe Phe Tyr Ile Lys Ser Pro Leu Arg Val Glu Glu Ala Gly 
        435                 440                 445             


Leu Gln Glu Leu Ile Pro Thr Thr Trp Trp Pro His Cys Ser Ser Arg 
    450                 455                 460                 


Glu Gly Lys Glu Ser Thr Glu Met Lys Glu Glu Thr Ala Glu Glu Arg 
465                 470                 475                 480 


Leu Arg Arg Arg Ala Tyr Glu Arg Gly Cys Gln Arg Leu Arg Lys Arg 
                485                 490                 495     


Ile Glu Val Val Glu Glu Leu Gln Val Gln Ile Leu Lys Leu Leu Leu 
            500                 505                 510         


Asp Asn Lys Asp Asp Asn Gly Gly Glu Ala Ser Arg Tyr Ile Phe Leu 
        515                 520                 525             


Thr Lys Phe Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly Asn 
    530                 535                 540                 


Met Pro Met Leu Cys Pro Pro Glu Tyr Met Val Cys Phe Leu His Arg 
545                 550                 555                 560 


Leu Ile Ser Ala Leu Arg Tyr Tyr Trp Asp Glu Tyr Lys Ala Ser Asn 
                565                 570                 575     


Pro His Ala Ser Phe Ser Glu Glu Ala Tyr Ile Pro Pro Gln Val Phe 
            580                 585                 590         


Tyr Asn Gly Lys Val Asp Tyr Phe Asp Leu Gln Arg Leu Gly Gly Leu 
        595                 600                 605             


Leu Ser His Leu Arg Lys Thr Leu Lys Asp Asp Leu Ala Ser Lys Ala 
    610                 615                 620                 


Asn Ile Val Ile Asp Pro Leu Glu Leu Gln Ser Thr Ala Met Asp Asp 
625                 630                 635                 640 


Leu Asp Glu Asp Glu Glu Pro Ala Pro Ala Met Ala Gln Arg Pro Met 
                645                 650                 655     


Gln Ala Leu Ala Val Gly Gly Pro Leu Pro Leu Pro Arg Pro Gly Trp 
            660                 665                 670         


Leu Ser Ser Pro Thr Leu Gly Arg Ala Asn Arg Phe Leu Ser Thr Ala 
        675                 680                 685             


Ala Val Ser Leu Met Thr Pro Arg Arg Pro Leu Ser Thr Ser Glu Lys 
    690                 695                 700                 


Val Lys Val Arg Thr Leu Ser Val Glu Gln Arg Thr Arg Glu Asp Ile 
705                 710                 715                 720 


Glu Gly Ser His Trp Asn Glu Gly Leu Leu Leu Gly Arg Pro Pro Glu 
                725                 730                 735     


Glu Pro Glu Gln Pro Leu Thr Glu Asn Ser Leu Leu Glu Val Leu Asp 
            740                 745                 750         


Gly Ala Val Met Met Tyr Asn Leu Ser Val His Gln Gln Leu Gly Lys 
        755                 760                 765             


Met Val Gly Val Ser Asp Asp Val Asn Glu Tyr Ala Met Ala Leu Arg 
    770                 775                 780                 


Asp Thr Glu Asp Lys Leu Arg Arg Cys Pro Lys Arg Arg Lys Asp Ile 
785                 790                 795                 800 


Leu Ala Glu Leu Thr Lys Ser Gln Lys Val Phe Ser Glu Lys Leu Asp 
                805                 810                 815     


His Leu Ser Arg Arg Leu Ala Trp Val His Ala Thr Val Tyr Ser Gln 
            820                 825                 830         


Glu Lys Met Leu Asp Ile Tyr Trp Leu Leu Arg Val Cys Leu Arg Thr 
        835                 840                 845             


Ile Glu His Gly Asp Arg Thr Gly Ser Leu Phe Ala Phe Met Pro Glu 
    850                 855                 860                 


Phe Tyr Leu Ser Val Ala Ile Asn Ser Tyr Ser Ala Leu Lys Asn Tyr 
865                 870                 875                 880 


Phe Gly Pro Val His Ser Met Glu Glu Leu Pro Gly Tyr Glu Glu Thr 
                885                 890                 895     


Leu Thr Arg Leu Ala Ala Ile Leu Ala Lys His Phe Ala Asp Ala Arg 
            900                 905                 910         


Ile Val Gly Thr Asp Ile Arg Asp Ser Leu Met Gln Ala Leu Ala Ser 
        915                 920                 925             


Tyr Val Cys Tyr Pro His Ser Leu Arg Ala Val Glu Arg Ile Pro Glu 
    930                 935                 940                 


Glu Gln Arg Ile Ala Met Val Arg Asn Leu Leu Ala Pro Tyr Glu Gln 
945                 950                 955                 960 


Arg Pro Trp Ala Gln Thr Asn Trp Ile Leu Val Arg Leu Trp Arg Gly 
                965                 970                 975     


Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu Leu Lys Thr 
            980                 985                 990         


Lys Leu Glu Asp Ala Asn Leu Pro  Ser Leu Gln Lys Pro  Cys Pro Ser 
        995                 1000                 1005             


Thr Leu  Leu Gln Gln His Met  Ala Asp Leu Leu Gln  Gln Gly Pro 
    1010                 1015                 1020             


Asp Val  Ala Pro Ser Phe Leu  Asn Ser Val Leu Asn  Gln Leu Asn 
    1025                 1030                 1035             


Trp Ala  Phe Ser Glu Phe Ile  Gly Met Ile Gln Glu  Ile Gln Gln 
    1040                 1045                 1050             


Ala Ala  Glu Arg Leu Glu Arg  Asn Phe Val Asp Ser  Arg Gln Leu 
    1055                 1060                 1065             


Lys Val  Cys Ala Thr Cys Phe  Asp Leu Ser Val Ser  Leu Leu Arg 
    1070                 1075                 1080             


Val Leu  Glu Met Thr Ile Thr  Leu Val Pro Glu Ile  Phe Leu Asp 
    1085                 1090                 1095             


Trp Thr  Arg Pro Thr Ser Glu  Met Leu Leu Arg Arg  Leu Ala Gln 
    1100                 1105                 1110             


Leu Leu  Asn Gln Val Leu Asn  Arg Val Thr Ala Glu  Arg Asn Leu 
    1115                 1120                 1125             


Phe Asp  Arg Val Val Thr Leu  Arg Leu Pro Gly Leu  Glu Ser Val 
    1130                 1135                 1140             


Asp His  Tyr Pro Ile Leu Val  Ala Val Thr Gly Ile  Leu Val Gln 
    1145                 1150                 1155             


Leu Leu  Val Arg Gly Pro Ala  Ser Glu Arg Glu Gln  Ala Thr Ser 
    1160                 1165                 1170             


Val Leu  Leu Ala Asp Pro Cys  Phe Gln Leu Arg Ser  Ile Cys Tyr 
    1175                 1180                 1185             


Leu Leu  Gly Gln Pro Glu Pro  Pro Ala Pro Gly Thr  Ala Leu Pro 
    1190                 1195                 1200             


Ala Pro  Asp Arg Lys Arg Phe  Ser Leu Gln Ser Tyr  Ala Asp Tyr 
    1205                 1210                 1215             


Ile Ser  Ala Asp Glu Leu Ala  Gln Val Glu Gln Met  Leu Ala His 
    1220                 1225                 1230             


Leu Thr  Ser Ala Ser Ala Gln  Ala Ala Ala Ala Ser  Leu Pro Thr 
    1235                 1240                 1245             


Ser Glu  Glu Asp Leu Cys Pro  Ile Cys Tyr Ala His  Pro Ile Ser 
    1250                 1255                 1260             


Ala Val  Phe Gln Pro Cys Gly  His Lys Ser Cys Lys  Ala Cys Ile 
    1265                 1270                 1275             


Asn Gln  His Leu Met Asn Asn  Lys Asp Cys Phe Phe  Cys Lys Thr 
    1280                 1285                 1290             


Thr Thr  Ser Asn Leu Leu Ala  Cys Leu Tyr Pro His  Trp Trp Glu 
    1295                 1300                 1305             


Pro Ser  His Gly Pro Asn Cys  Ala 
    1310                 1315     


<210> 6719
<211> 680
<212> PRT
<213> Homo sapiens

<400> 6719
Met Pro Ser Val Ser Lys Ala Ala Ala Ala Ala Leu Ser Gly Ser Pro 
1               5                   10                  15      


Pro Gln Thr Glu Lys Pro Thr His Tyr Arg Tyr Leu Lys Glu Phe Arg 
            20                  25                  30          


Thr Glu Gln Cys Pro Leu Phe Ser Gln His Lys Cys Ala Gln His Arg 
        35                  40                  45              


Pro Phe Thr Cys Phe His Trp His Phe Leu Asn Gln Arg Arg Arg Arg 
    50                  55                  60                  


Pro Leu Arg Arg Arg Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val Tyr 
65                  70                  75                  80  


Cys Ser Lys Tyr Asn Glu Ala Thr Gly Val Cys Pro Asp Gly Asp Glu 
                85                  90                  95      


Cys Pro Tyr Leu His Arg Thr Thr Gly Asp Thr Glu Arg Lys Tyr His 
            100                 105                 110         


Leu Arg Tyr Tyr Lys Thr Gly Thr Cys Ile His Glu Thr Asp Ala Arg 
        115                 120                 125             


Gly His Cys Val Lys Asn Gly Leu His Cys Ala Phe Ala His Gly Pro 
    130                 135                 140                 


Leu Asp Leu Arg Pro Pro Val Cys Asp Val Arg Glu Leu Gln Ala Gln 
145                 150                 155                 160 


Glu Ala Leu Gln Asn Gly Gln Leu Gly Gly Gly Glu Gly Val Pro Asp 
                165                 170                 175     


Leu Gln Pro Gly Val Leu Ala Ser Gln Ala Met Ile Glu Lys Ile Leu 
            180                 185                 190         


Ser Glu Asp Pro Arg Trp Gln Asp Ala Asn Phe Val Leu Gly Ser Tyr 
        195                 200                 205             


Lys Thr Glu Gln Cys Pro Lys Pro Pro Arg Leu Cys Arg Gln Gly Tyr 
    210                 215                 220                 


Ala Cys Pro His Tyr His Asn Ser Arg Asp Arg Arg Arg Asn Pro Arg 
225                 230                 235                 240 


Arg Phe Gln Tyr Arg Ser Thr Pro Cys Pro Ser Val Lys His Gly Asp 
                245                 250                 255     


Glu Trp Gly Glu Pro Ser Arg Cys Asp Gly Gly Asp Gly Cys Gln Tyr 
            260                 265                 270         


Cys His Ser Arg Thr Glu Gln Gln Phe His Pro Glu Ser Thr Lys Cys 
        275                 280                 285             


Asn Asp Met Arg Gln Thr Gly Tyr Cys Pro Arg Gly Pro Phe Cys Ala 
    290                 295                 300                 


Phe Ala His Val Glu Lys Ser Leu Gly Met Val Asn Glu Trp Gly Cys 
305                 310                 315                 320 


His Asp Leu His Leu Thr Ser Pro Ser Ser Thr Gly Ser Gly Gln Pro 
                325                 330                 335     


Gly Asn Ala Lys Arg Arg Asp Ser Pro Ala Glu Gly Gly Pro Arg Gly 
            340                 345                 350         


Ser Glu Gln Asp Ser Lys Gln Asn His Leu Ala Val Phe Ala Ala Val 
        355                 360                 365             


His Pro Pro Ala Pro Ser Val Ser Ser Ser Val Ala Ser Ser Leu Ala 
    370                 375                 380                 


Ser Ser Ala Gly Ser Gly Ser Ser Ser Pro Thr Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Pro Ala Arg Ala Leu Pro Leu Gly Pro Ala Ser Ser Thr Val Glu Ala 
                405                 410                 415     


Val Leu Gly Ser Ala Leu Asp Leu His Leu Ser Asn Val Asn Ile Ala 
            420                 425                 430         


Ser Leu Glu Lys Asp Leu Glu Glu Gln Asp Gly His Asp Leu Gly Ala 
        435                 440                 445             


Ala Gly Pro Arg Ser Leu Ala Gly Ser Ala Pro Val Ala Ile Pro Gly 
    450                 455                 460                 


Ser Leu Pro Arg Ala Pro Ser Leu His Ser Pro Ser Ser Ala Ser Thr 
465                 470                 475                 480 


Ser Pro Leu Gly Ser Leu Ser Gln Pro Leu Pro Gly Pro Val Gly Ser 
                485                 490                 495     


Ser Ala Met Thr Pro Pro Gln Gln Pro Pro Pro Leu Arg Ser Glu Pro 
            500                 505                 510         


Gly Thr Leu Gly Ser Ala Ala Ser Ser Tyr Ser Pro Leu Gly Leu Asn 
        515                 520                 525             


Gly Val Pro Gly Ser Ile Trp Asp Phe Val Ser Gly Ser Phe Ser Pro 
    530                 535                 540                 


Ser Pro Ser Pro Ile Leu Ser Ala Gly Pro Pro Ser Ser Ser Ser Ala 
545                 550                 555                 560 


Ser Pro Asn Gly Ala Glu Leu Ala Arg Val Arg Arg Gln Leu Asp Glu 
                565                 570                 575     


Ala Lys Arg Lys Ile Arg Gln Trp Glu Glu Ser Trp Gln Gln Val Lys 
            580                 585                 590         


Gln Val Cys Asp Ala Trp Gln Arg Glu Ala Gln Glu Ala Lys Glu Arg 
        595                 600                 605             


Ala Arg Val Ala Asp Ser Asp Arg Gln Leu Ala Leu Gln Lys Lys Glu 
    610                 615                 620                 


Glu Val Glu Ala Gln Val Ile Phe Gln Leu Arg Ala Lys Gln Cys Val 
625                 630                 635                 640 


Ala Cys Arg Glu Arg Ala His Gly Ala Val Leu Arg Pro Cys Gln His 
                645                 650                 655     


His Ile Leu Cys Glu Pro Cys Ala Ala Thr Ala Pro Glu Cys Pro Tyr 
            660                 665                 670         


Cys Lys Gly Gln Pro Leu Gln Trp 
        675                 680 


<210> 6720
<211> 153
<212> PRT
<213> Homo sapiens

<400> 6720
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro 
145                 150             


<210> 6721
<211> 793
<212> PRT
<213> Homo sapiens

<400> 6721
Met Gly Gln Cys Tyr Asn Leu Glu Asp Asp Asp Leu Glu Thr Asp Val 
1               5                   10                  15      


Asn Lys Leu Ser Ser Lys Pro Gly Leu Asp Arg Pro Glu Glu Glu Leu 
            20                  25                  30          


Met Gln Tyr Glu Val Met Cys Leu Glu Leu Ser Tyr Ser Phe Glu Glu 
        35                  40                  45              


Leu Gln Ser Lys Leu Gly Asp Asp Leu Asn Ser Glu Lys Thr Gln Tyr 
    50                  55                  60                  


Ala Asn His His His Ile Pro Ala Ala Ala Ser Ser Lys Gln His Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Gln Ser Ser Cys Gly Gln Glu Arg Glu Tyr Ala Val 
                85                  90                  95      


Gln Thr Ser Leu Leu Cys Arg Val Lys Thr Gly Arg Ser Thr Val His 
            100                 105                 110         


Leu Gly Ser Lys Lys Asn Pro Gly Val Asn Leu Tyr Gln Asn Val Gln 
        115                 120                 125             


Ser Asn Ser Leu Arg Arg Asp Ser Ser Glu Ser Glu Ile Pro Asp Ile 
    130                 135                 140                 


Gln Ala Ser Pro Lys Ala Asp Ala Trp Asp Val Asp Ala Ile Phe Cys 
145                 150                 155                 160 


Pro Arg Met Ser Ala Ser Phe Ser Asn Ser Thr Arg Thr Arg Glu Val 
                165                 170                 175     


Val Lys Val Ile Asp Lys Leu Leu Gln Thr His Leu Lys Arg Val Pro 
            180                 185                 190         


Phe His Asp Pro Tyr Leu Tyr Met Ala Lys Ala Arg Arg Thr Ser Ser 
        195                 200                 205             


Val Val Asp Phe Lys Met Met Ala Phe Pro Asp Val Trp Gly His Cys 
    210                 215                 220                 


Pro Pro Pro Thr Thr Gln Pro Met Leu Glu Arg Lys Cys Gly Val Gln 
225                 230                 235                 240 


Arg Ile Arg Ile Phe Glu Asp Ile Arg Arg Leu Ile Gln Pro Ser Asp 
                245                 250                 255     


Val Ile Asn Lys Val Val Phe Ser Leu Asp Glu Pro Trp Pro Leu Gln 
            260                 265                 270         


Asp Asn Ala Ser Asn Cys Leu Arg Phe Phe Ser Lys Phe Glu Ser Gly 
        275                 280                 285             


Asn Leu Arg Lys Ala Ile Gln Val Arg Glu Phe Glu Tyr Asp Leu Leu 
    290                 295                 300                 


Val Asn Ala Asp Val Asn Ser Thr Gln His Gln Gln Trp Phe Tyr Phe 
305                 310                 315                 320 


Lys Val Ser Gly Met Gln Ala Ala Ile Pro Tyr His Phe Asn Ile Ile 
                325                 330                 335     


Asn Cys Glu Lys Pro Asn Ser Gln Phe Asn Tyr Gly Met Gln Pro Thr 
            340                 345                 350         


Leu Tyr Ser Val Lys Glu Ala Leu Leu Gly Lys Pro Thr Trp Ile Arg 
        355                 360                 365             


Thr Gly His Glu Ile Cys Tyr Tyr Lys Asn His Tyr Arg Gln Ser Thr 
    370                 375                 380                 


Ala Val Ala Gly Gly Ala Ser Gly Lys Cys Tyr Tyr Thr Leu Thr Phe 
385                 390                 395                 400 


Ala Val Thr Phe Pro His Ser Glu Asp Val Cys Tyr Leu Ala Tyr His 
                405                 410                 415     


Tyr Pro Tyr Thr Tyr Thr Ala Leu Met Thr His Leu Asp Ile Leu Glu 
            420                 425                 430         


Lys Ser Val Asn Leu Lys Glu Val Tyr Phe Arg Gln Asp Val Leu Cys 
        435                 440                 445             


Gln Thr Leu Gly Gly Asn Pro Cys Pro Leu Val Thr Ile Thr Ala Met 
    450                 455                 460                 


Pro Glu Ser Asn Ser Asp Glu His Leu Glu Gln Phe Arg His Arg Pro 
465                 470                 475                 480 


Tyr Gln Val Ile Thr Ala Arg Val His Pro Gly Glu Ser Asn Ala Ser 
                485                 490                 495     


Trp Val Met Lys Gly Thr Leu Glu Phe Leu Val Ser Ser Asp Pro Val 
            500                 505                 510         


Ala Arg Leu Leu Arg Glu Asn Phe Ile Phe Lys Ile Ile Pro Met Leu 
        515                 520                 525             


Asn Pro Asp Gly Val Ile Asn Gly Asn His Arg Cys Ser Leu Ser Gly 
    530                 535                 540                 


Glu Asp Leu Asn Arg Gln Trp Leu Ser Pro Ser Ala His Leu Gln Pro 
545                 550                 555                 560 


Thr Ile Tyr His Ala Lys Gly Leu Leu Tyr His Leu Ser Ser Ile Gly 
                565                 570                 575     


Arg Ser Pro Val Val Phe Cys Asp Phe His Gly His Ser Gln Lys Lys 
            580                 585                 590         


Asn Val Phe Leu Tyr Gly Cys Ser Ile Lys Glu Thr Leu Trp Gln Ala 
        595                 600                 605             


Ala Cys Thr Val Gly Thr Ser Thr Ile Leu Glu Glu Val Asn Tyr Arg 
    610                 615                 620                 


Thr Leu Pro Lys Ile Leu Asp Lys Leu Ala Pro Ala Phe Thr Met Ser 
625                 630                 635                 640 


Ser Cys Ser Phe Leu Val Glu Lys Ser Arg Ala Ser Thr Ala Arg Val 
                645                 650                 655     


Val Val Trp Arg Glu Met Gly Val Ser Arg Ser Tyr Thr Met Glu Ser 
            660                 665                 670         


Ser Tyr Cys Gly Cys Asn Gln Gly Pro Tyr Gln Cys Thr Gln Arg Leu 
        675                 680                 685             


Leu Glu Arg Thr Lys Asn Glu Arg Ala His Pro Val Asp Gly Leu Gln 
    690                 695                 700                 


Gly Leu Gln Phe Gly Thr Arg Glu Leu Glu Glu Met Gly Ala Met Phe 
705                 710                 715                 720 


Cys Leu Gly Leu Leu Ile Leu Glu Leu Lys Ser Ala Ser Cys Ser His 
                725                 730                 735     


Gln Leu Leu Ala Gln Ala Ala Thr Leu Leu Ser Ala Glu Glu Asp Ala 
            740                 745                 750         


Leu Asp Gln His Leu Gln Arg Leu Lys Ser Ser Asn Phe Leu Pro Lys 
        755                 760                 765             


His Ile Trp Phe Ala Tyr His Phe Phe Ala Ile Thr Asn Phe Phe Lys 
    770                 775                 780                 


Met Asn Leu Leu Leu His Val Ser Pro 
785                 790             


<210> 6722
<211> 50
<212> PRT
<213> Homo sapiens

<400> 6722
Met Met Gln Asn Val His Leu Ala Pro Glu Thr Asp Glu Asp Asp Leu 
1               5                   10                  15      


Tyr Ser Gly Tyr Asn Asp Tyr Asn Pro Ile Tyr Asp Ile Glu Glu Leu 
            20                  25                  30          


Glu Asn Asp Ala Ala Phe Gln Gln Ala Val Arg Thr Ser His Gly Arg 
        35                  40                  45              


Arg Pro 
    50  


<210> 6723
<211> 432
<212> PRT
<213> Homo sapiens

<400> 6723
Met Thr Ala Val Arg Ala Ala Gly Phe Thr Lys Ala Ala Leu Arg Gly 
1               5                   10                  15      


Ser Ala Phe Asp Pro Leu Ser Gln Ser Arg Gly Pro Ala Ser Pro Leu 
            20                  25                  30          


Glu Ala Lys Lys Lys Asp Ser Pro Glu Glu Lys Ile Lys Gln Leu Glu 
        35                  40                  45              


Lys Glu Val Asn Glu Leu Val Glu Glu Ser Cys Ile Ala Asn Ser Cys 
    50                  55                  60                  


Gly Asp Leu Lys Leu Ala Leu Glu Lys Ala Lys Asp Ala Gly Arg Lys 
65                  70                  75                  80  


Glu Arg Val Leu Val Arg Gln Arg Glu Gln Val Thr Thr Pro Glu Asn 
                85                  90                  95      


Ile Asn Leu Asp Leu Thr Tyr Ser Val Leu Phe Asn Leu Ala Ser Gln 
            100                 105                 110         


Tyr Ser Val Asn Glu Met Tyr Ala Glu Ala Leu Asn Thr Tyr Gln Val 
        115                 120                 125             


Ile Val Lys Asn Lys Met Phe Ser Asn Ala Gly Ile Leu Lys Met Asn 
    130                 135                 140                 


Met Gly Asn Ile Tyr Leu Lys Gln Arg Asn Tyr Ser Lys Ala Ile Lys 
145                 150                 155                 160 


Phe Tyr Arg Met Ala Leu Asp Gln Val Pro Ser Val Asn Lys Gln Met 
                165                 170                 175     


Arg Ile Lys Ile Met Gln Asn Ile Gly Val Thr Phe Ile Gln Ala Asp 
            180                 185                 190         


Arg Glu Lys Met Lys Lys Ala Phe Gln Lys Leu Ile Thr Val Pro Leu 
        195                 200                 205             


Glu Ile Asp Glu Asp Lys Tyr Ile Ser Pro Ser Asp Asp Pro His Thr 
    210                 215                 220                 


Asn Leu Val Thr Glu Ala Ile Lys Asn Asp His Leu Arg Gln Met Glu 
225                 230                 235                 240 


Arg Glu Arg Lys Ala Met Ala Glu Lys Tyr Ile Met Thr Ser Ala Lys 
                245                 250                 255     


Leu Ile Ala Pro Val Ile Glu Thr Ser Phe Ala Ala Gly Tyr Asp Trp 
            260                 265                 270         


Cys Val Glu Val Val Lys Ala Ser Gln Tyr Val Glu Leu Ala Asn Asp 
        275                 280                 285             


Leu Glu Ile Asn Lys Ala Val Thr Tyr Leu Arg Gln Lys Asp Tyr Asn 
    290                 295                 300                 


Gln Ala Val Glu Ile Leu Lys Val Leu Glu Lys Lys Asp Ser Arg Val 
305                 310                 315                 320 


Lys Ser Ala Ala Ala Thr Asn Leu Ser Ala Leu Tyr Tyr Met Gly Lys 
                325                 330                 335     


Asp Phe Ala Gln Ala Ser Ser Tyr Ala Asp Ile Ala Val Asn Ser Asp 
            340                 345                 350         


Arg Tyr Asn Pro Ala Ala Leu Thr Asn Lys Gly Asn Thr Val Phe Ala 
        355                 360                 365             


Asn Gly Asp Tyr Glu Lys Ala Ala Glu Phe Tyr Lys Glu Ala Leu Arg 
    370                 375                 380                 


Asn Asp Ser Ser Cys Thr Glu Ala Leu Tyr Asn Ile Gly Leu Thr Tyr 
385                 390                 395                 400 


Glu Lys Leu Asn Arg Leu Asp Glu Ala Leu Asp Cys Phe Leu Lys Leu 
                405                 410                 415     


His Ala Ile Leu Arg Asn Ser Ala Glu Val Leu Tyr Gln Ile Ala Asn 
            420                 425                 430         


<210> 6724
<211> 128
<212> PRT
<213> Homo sapiens

<400> 6724
Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu Leu Gly 
1               5                   10                  15      


Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu Ala Arg 
            20                  25                  30          


Gln Met Ala Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp 
        35                  40                  45              


Glu Val Tyr Pro Ala Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser 
    50                  55                  60                  


Glu Leu Leu Met Ile Ile Gln Met Glu Thr Gln Ser Ser Met Arg Lys 
65                  70                  75                  80  


Lys Val Cys Asp Ile Ala Ala Glu Leu Ala Arg Asn Leu Ile Asp Glu 
                85                  90                  95      


Asp Gly Asn Asn Gln Trp Pro Glu Gly Leu Lys Phe Leu Phe Asp Ser 
            100                 105                 110         


Val Ser Ser Gln Asn Val Gly Leu Arg Glu Ala Ala Leu His Ile Phe 
        115                 120                 125             


<210> 6725
<211> 921
<212> PRT
<213> Homo sapiens

<400> 6725
Met Arg Pro Glu Gly Ala Gly Met Glu Leu Gly Gly Gly Glu Glu Arg 
1               5                   10                  15      


Leu Pro Glu Glu Ser Arg Arg Glu His Trp Gln Leu Leu Gly Asn Leu 
            20                  25                  30          


Lys Thr Thr Val Glu Gly Leu Val Ser Thr Asn Ser Pro Asn Val Trp 
        35                  40                  45              


Ser Lys Tyr Gly Gly Leu Glu Arg Leu Cys Arg Asp Met Gln Ser Ile 
    50                  55                  60                  


Leu Tyr His Gly Leu Ile Arg Asp Gln Ala Cys Arg Arg Gln Thr Asp 
65                  70                  75                  80  


Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser Pro His Ser Ala 
                85                  90                  95      


Leu His Val Glu Lys Phe Ile Ser Val His Glu Asn Asp Gln Ser Ser 
            100                 105                 110         


Ala Asp Gly Ala Ser Glu Arg Ala Val Ala Glu Leu Trp Leu Gln His 
        115                 120                 125             


Ser Leu Gln Tyr His Cys Leu Ser Ala Gln Leu Arg Pro Leu Leu Gly 
    130                 135                 140                 


Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Asp Ala Ala Phe Leu Leu 
145                 150                 155                 160 


Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu Glu Ala Val Glu 
                165                 170                 175     


Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala Ser Met Phe Ala 
            180                 185                 190         


Arg Lys His Glu Ser Pro Leu Leu Val Thr Lys Ser Gln Ser Leu Thr 
        195                 200                 205             


Ala Leu Pro Ser Ser Thr Tyr Thr Pro Pro Asn Ser Tyr Ala Gln His 
    210                 215                 220                 


Ser Tyr Phe Gly Ser Phe Ser Ser Leu His Gln Ser Val Pro Asn Asn 
225                 230                 235                 240 


Gly Ser Glu Arg Arg Ser Thr Ser Phe Pro Leu Ser Gly Pro Pro Arg 
                245                 250                 255     


Lys Pro Gln Glu Ser Arg Gly His Val Ser Pro Ala Glu Asp Gln Thr 
            260                 265                 270         


Ile Gln Ala Pro Pro Val Ser Val Ser Ala Leu Ala Arg Asp Ser Pro 
        275                 280                 285             


Leu Thr Pro Asn Glu Met Ser Ser Ser Thr Leu Thr Ser Pro Ile Glu 
    290                 295                 300                 


Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Gly Asp Ala Ser Glu 
305                 310                 315                 320 


Gly Pro Glu Tyr Leu Ala Ile Gly Asn Leu Asp Pro Arg Gly Arg Thr 
                325                 330                 335     


Ala Ser Cys Gln Ser His Ser Ser Asn Ala Glu Ser Ser Ser Ser Asn 
            340                 345                 350         


Leu Phe Ser Ser Ser Ser Ser Gln Lys Pro Asp Ser Ala Ala Ser Ser 
        355                 360                 365             


Leu Gly Asp Gln Glu Gly Gly Gly Glu Ser Gln Leu Ser Ser Val Leu 
    370                 375                 380                 


Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Leu Thr Val Thr Ser Gly 
385                 390                 395                 400 


Ala Lys Lys Ser His Ile Arg Ser His Ser Asp Thr Ser Ile Ala Ser 
                405                 410                 415     


Arg Gly Ala Pro Glu Ser Cys Asn Asp Lys Ala Lys Leu Arg Gly Pro 
            420                 425                 430         


Leu Pro Tyr Ser Gly Gln Ser Ser Glu Val Ser Thr Pro Ser Ser Leu 
        435                 440                 445             


Tyr Met Glu Tyr Glu Gly Gly Arg Tyr Leu Cys Ser Gly Glu Gly Met 
    450                 455                 460                 


Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr Leu Ser Glu 
465                 470                 475                 480 


Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn Ala His Phe 
                485                 490                 495     


Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met Lys Cys Asn 
            500                 505                 510         


Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu Glu Asp Ser 
        515                 520                 525             


Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu Arg Arg Gln 
    530                 535                 540                 


Gln Ile Arg Thr Lys Asn Leu Leu Pro Met Tyr Gln Glu Ala Glu His 
545                 550                 555                 560 


Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser Ser Arg Asp 
                565                 570                 575     


Ser Ala Gln Leu Ser Asp Ser Gly Ser Ala Asp Glu Val Asp Glu Phe 
            580                 585                 590         


Glu Ile Gln Asp Gly Ser Glu Gly Ser Asn Leu Thr His Ile Ser Lys 
        595                 600                 605             


Asn Gly Leu Ser Val Ser Leu Ala Ser Met Phe Ser Asp Ala Asp Ile 
    610                 615                 620                 


Arg Arg Asn Thr Ala Ser Ser Ser Lys Ser Phe Val Ser Ser Gln Ser 
625                 630                 635                 640 


Phe Ser His Cys Phe Leu His Ser Thr Ser Ala Glu Ala Val Ala Met 
                645                 650                 655     


Gly Leu Leu Lys Gln Phe Glu Gly Met Gln Leu Pro Ala Ala Ser Glu 
            660                 665                 670         


Leu Glu Trp Leu Val Pro Glu His Asp Ala Pro Gln Lys Leu Leu Pro 
        675                 680                 685             


Ile Pro Asp Ser Leu Pro Ile Ser Pro Asp Asp Gly Gln His Ala Asp 
    690                 695                 700                 


Ile Tyr Lys Leu Arg Ile Arg Val Arg Gly Asn Leu Glu Trp Ala Pro 
705                 710                 715                 720 


Pro Arg Pro Gln Ile Ile Phe Asn Val His Pro Ala Pro Thr Arg Lys 
                725                 730                 735     


Ile Ala Val Ala Lys Gln Asn Tyr Arg Cys Ala Gly Cys Gly Ile Arg 
            740                 745                 750         


Thr Asp Pro Asp Tyr Ile Lys Arg Leu Arg Tyr Cys Glu Tyr Leu Gly 
        755                 760                 765             


Lys Tyr Phe Cys Gln Cys Cys His Glu Asn Ala Gln Met Ala Ile Pro 
    770                 775                 780                 


Ser Arg Val Leu Arg Lys Trp Asp Phe Ser Lys Tyr Tyr Val Ser Asn 
785                 790                 795                 800 


Phe Ser Lys Asp Leu Leu Ile Lys Ile Trp Asn Asp Pro Leu Phe Asn 
                805                 810                 815     


Val Gln Asp Ile Asn Ser Ala Leu Tyr Arg Lys Val Lys Leu Leu Asn 
            820                 825                 830         


Gln Val Arg Leu Leu Arg Val Gln Leu Cys His Met Lys Asn Met Phe 
        835                 840                 845             


Lys Thr Cys Arg Leu Ala Lys Glu Leu Leu Asp Ser Phe Asp Thr Val 
    850                 855                 860                 


Pro Gly His Leu Thr Glu Asp Leu His Leu Tyr Ser Leu Asn Asp Leu 
865                 870                 875                 880 


Thr Ala Thr Arg Lys Gly Glu Leu Gly Pro Arg Leu Ala Glu Leu Thr 
                885                 890                 895     


Arg Ala Gly Ala Thr His Val Glu Arg Cys Met Val Arg Lys Ser His 
            900                 905                 910         


Cys Ser Met Gln Leu Ser Pro Cys Phe 
        915                 920     


<210> 6726
<211> 547
<212> PRT
<213> Homo sapiens

<400> 6726
Met Arg Ala Leu Thr Val Gln Arg Val Lys Phe Ala Met Asp Leu Pro 
1               5                   10                  15      


Leu Leu Lys Arg Ala Gly Gln Asp Leu Ala Glu Lys Thr Lys Asn Phe 
            20                  25                  30          


Val Ser Arg Ser Leu Val Ile Gly Glu Val Leu Ser Met Ala Asp Met 
        35                  40                  45              


Ala Thr Gly Val Lys Cys Gly Ile Ile Tyr Trp Leu Phe Gly Gly Ala 
    50                  55                  60                  


Ile Arg Asn Leu Gly Ser Pro Glu His Val Thr Lys Trp Phe Gln Pro 
65                  70                  75                  80  


Leu Gln Glu Gln Lys Tyr Thr Gly Met Phe Ala Met Thr Glu Arg Gly 
                85                  90                  95      


His Gly Ser Asn Ala Arg Gly Ile Gln Thr Glu Ala Thr Phe Asp Leu 
            100                 105                 110         


Ser Ala Gln Glu Phe Val Ile Asp Thr Pro Cys Glu Asn Ala Glu Lys 
        115                 120                 125             


Met Tyr Ile Gly Asn Ala Met Tyr Gly Asn Tyr Ala Ala Val Phe Ala 
    130                 135                 140                 


Gln Leu Ile Ile Asp Gly Arg Ser Gln Gly Pro His Cys Phe Ile Val 
145                 150                 155                 160 


Pro Val Arg Asp Glu Asn Gly Ser Leu Tyr Pro Gly Val Thr Ala Ile 
                165                 170                 175     


Asp Met Met Tyr Lys Glu Gly Leu His Gly Val Asp Asn Gly Ile Leu 
            180                 185                 190         


Ile Phe Asp Lys Val Arg Ile Pro Arg Glu Asn Leu Leu Asp Lys Phe 
        195                 200                 205             


Gly Ser Val Ala Pro Asp Gly Gln Tyr His Ser Pro Ile Arg Asn Lys 
    210                 215                 220                 


Ser Ala Arg Phe Asn Ala Met Leu Ala Ala Leu Thr Pro Ser Arg Leu 
225                 230                 235                 240 


Ala Val Ala Phe Gln Ala Met Gly Ala Met Lys Leu Gly Leu Thr Ile 
                245                 250                 255     


Ala Ile Arg Tyr Ser His Ser Arg Arg Gln Phe Gly Pro Lys Thr Lys 
            260                 265                 270         


Glu Glu Val Lys Ile Ile Glu His Gln Thr Gln Thr Leu Arg Leu Met 
        275                 280                 285             


Pro His Leu Ala Thr Ala Leu Ala Leu Thr Phe Val Ser Arg Tyr Ala 
    290                 295                 300                 


Gly Ala Leu Leu Asp Glu Asp Val Phe Gln Gly Lys Glu Leu Val Asn 
305                 310                 315                 320 


Ser Arg Ser Leu Gln Ala Leu Val Ala Gly Leu Lys Ala Tyr Ser Thr 
                325                 330                 335     


Trp Glu Asn Ile Arg Cys Leu Gln Asp Cys Arg Glu Cys Thr Gly Gly 
            340                 345                 350         


Met Gly Tyr Met Met Glu Asn Arg Ile Ser Gly Leu Lys Cys Asp Thr 
        355                 360                 365             


Asp Val Phe Ala Thr Phe Glu Gly Asp Asp Val Val Met Leu Gln Val 
    370                 375                 380                 


Val Gly Arg Glu Leu Leu Ala Gln Tyr Thr Lys Gln Tyr Glu Glu Lys 
385                 390                 395                 400 


Pro Leu Phe Gly Leu Leu Gln Asn Trp Ala Glu Ser Val Gly Asp Lys 
                405                 410                 415     


Leu Arg Thr Ser Phe Leu Ala Phe Asn Met Asp Thr Val Asp Asp Leu 
            420                 425                 430         


Ala Phe Leu Leu Lys Ala Val Lys Phe Arg Glu Arg Val Leu Gln Arg 
        435                 440                 445             


Gly Leu Val Ala Arg Ile Tyr Tyr Lys Val Lys Thr Lys Lys Glu Asp 
    450                 455                 460                 


Phe Phe His Ala Trp Asn Ser Cys Leu His His Val Ala Ser Leu Ser 
465                 470                 475                 480 


Leu Ala His Thr His Arg Val Thr Leu Glu Gln Phe Ser Leu Ala Val 
                485                 490                 495     


Lys Ser Cys Pro Asp Gln Glu Asp Gln Thr Leu Leu Met Lys Phe Cys 
            500                 505                 510         


Leu Leu Tyr Gly Thr Lys Leu Val Phe Gln Glu Arg Ala Trp Tyr Leu 
        515                 520                 525             


Glu His Lys Tyr Leu Thr Pro Met Ala Ser Thr Arg Ile Arg Asn Gln 
    530                 535                 540                 


Glu Arg Cys 
545         


<210> 6727
<211> 2028
<212> PRT
<213> Homo sapiens

<400> 6727
Met Asp Val Thr Val Ser Glu Leu Leu Glu Leu Phe Leu Gln Ser Pro 
1               5                   10                  15      


Leu Val Thr Trp Val Lys Thr Phe Gly Pro Phe Gly Ser Gly Ser Gln 
            20                  25                  30          


Asp Asn Leu Thr Met Tyr Met Asp Leu Val Asp Gly Ile Phe Leu Asn 
        35                  40                  45              


Gln Ile Met Leu Gln Ile Asp Pro Arg Pro Thr Asn Gln Arg Ile Asn 
    50                  55                  60                  


Lys His Val Asn Asn Asp Val Asn Leu Arg Ile Gln Asn Leu Thr Ile 
65                  70                  75                  80  


Leu Val Arg Asn Ile Lys Thr Tyr Tyr Gln Glu Val Leu Gln Gln Leu 
                85                  90                  95      


Ile Val Met Asn Leu Pro Asn Val Leu Met Ile Gly Arg Asp Pro Leu 
            100                 105                 110         


Ser Gly Lys Ser Met Glu Glu Ile Lys Lys Val Leu Leu Leu Val Leu 
        115                 120                 125             


Gly Cys Ala Val Gln Cys Glu Arg Lys Glu Glu Phe Ile Glu Arg Ile 
    130                 135                 140                 


Lys Gln Leu Asp Ile Glu Thr Gln Ala Gly Ile Val Ala His Ile Gln 
145                 150                 155                 160 


Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Leu Glu 
                165                 170                 175     


Leu Pro Asp Val Ala Pro Glu Glu Leu Glu Ala Leu Ser Arg Ser Met 
            180                 185                 190         


Val Leu His Leu Arg Arg Leu Ile Asp Gln Arg Asp Glu Cys Thr Glu 
        195                 200                 205             


Leu Ile Val Asp Leu Thr Gln Glu Arg Asp Tyr Leu Gln Ala Gln His 
    210                 215                 220                 


Pro Pro Ser Pro Ile Lys Ser Ser Ser Ala Asp Ser Thr Pro Ser Pro 
225                 230                 235                 240 


Thr Ser Ser Leu Ser Ser Glu Asp Lys Gln His Leu Ala Val Glu Leu 
                245                 250                 255     


Ala Asp Thr Lys Ala Arg Leu Arg Arg Val Arg Gln Glu Leu Glu Asp 
            260                 265                 270         


Lys Thr Glu Gln Leu Val Asp Thr Arg His Glu Val Asp Gln Leu Val 
        275                 280                 285             


Leu Glu Leu Gln Lys Val Lys Gln Glu Asn Ile Gln Leu Ala Ala Asp 
    290                 295                 300                 


Ala Arg Ser Ala Arg Ala Tyr Arg Asp Glu Leu Asp Ser Leu Arg Glu 
305                 310                 315                 320 


Lys Ala Asn Arg Val Glu Arg Leu Glu Leu Glu Leu Thr Arg Cys Lys 
                325                 330                 335     


Glu Lys Leu His Asp Val Asp Phe Tyr Lys Ala Arg Met Glu Glu Leu 
            340                 345                 350         


Arg Glu Asp Asn Ile Ile Leu Ile Glu Thr Lys Ala Met Leu Glu Glu 
        355                 360                 365             


Gln Leu Thr Ala Ala Arg Ala Arg Gly Asp Lys Val His Glu Leu Glu 
    370                 375                 380                 


Lys Glu Asn Leu Gln Leu Lys Ser Lys Leu His Asp Leu Glu Leu Asp 
385                 390                 395                 400 


Arg Asp Thr Asp Lys Lys Arg Ile Glu Glu Leu Leu Glu Glu Asn Met 
                405                 410                 415     


Val Leu Glu Ile Ala Gln Lys Gln Ser Met Asn Glu Ser Ala His Leu 
            420                 425                 430         


Gly Trp Glu Leu Glu Gln Leu Ser Lys Asn Ala Asp Leu Ser Asp Ala 
        435                 440                 445             


Ser Arg Lys Ser Phe Val Phe Glu Leu Asn Glu Cys Ala Ser Ser Arg 
    450                 455                 460                 


Ile Leu Lys Leu Glu Lys Glu Asn Gln Ser Leu Gln Ser Thr Ile Gln 
465                 470                 475                 480 


Gly Leu Arg Asp Ala Ser Leu Val Leu Glu Glu Ser Gly Leu Lys Cys 
                485                 490                 495     


Gly Glu Leu Glu Lys Glu Asn His Gln Leu Ser Lys Lys Ile Glu Lys 
            500                 505                 510         


Leu Gln Thr Gln Leu Glu Arg Glu Lys Gln Ser Asn Gln Asp Leu Glu 
        515                 520                 525             


Thr Leu Ser Glu Glu Leu Ile Arg Glu Lys Glu Gln Leu Gln Ser Asp 
    530                 535                 540                 


Met Glu Thr Leu Lys Ala Asp Lys Ala Arg Gln Ile Lys Asp Leu Glu 
545                 550                 555                 560 


Gln Glu Lys Asp His Leu Asn Arg Ala Met Trp Ser Leu Arg Glu Arg 
                565                 570                 575     


Ser Gln Val Ser Ser Glu Ala Arg Met Lys Asp Val Glu Lys Glu Asn 
            580                 585                 590         


Lys Ala Leu His Gln Thr Val Thr Glu Ala Asn Gly Lys Leu Ser Gln 
        595                 600                 605             


Leu Glu Phe Glu Lys Arg Gln Leu His Arg Asp Leu Glu Gln Ala Lys 
    610                 615                 620                 


Glu Lys Gly Glu Arg Ala Glu Lys Leu Glu Arg Glu Leu Gln Arg Leu 
625                 630                 635                 640 


Gln Glu Glu Asn Gly Arg Leu Ala Arg Lys Val Thr Ser Leu Glu Thr 
                645                 650                 655     


Ala Thr Glu Lys Val Glu Ala Leu Glu His Glu Ser Gln Gly Leu Gln 
            660                 665                 670         


Leu Glu Asn Arg Thr Leu Arg Lys Ser Leu Asp Thr Leu Gln Asn Val 
        675                 680                 685             


Ser Leu Gln Leu Glu Gly Leu Glu Arg Asp Asn Lys Gln Leu Asp Ala 
    690                 695                 700                 


Glu Asn Leu Glu Leu Arg Arg Leu Val Glu Thr Met Arg Phe Thr Ser 
705                 710                 715                 720 


Thr Lys Leu Ala Gln Met Glu Arg Glu Asn Gln Gln Leu Glu Arg Glu 
                725                 730                 735     


Lys Glu Glu Leu Arg Lys Asn Val Asp Leu Leu Lys Ala Leu Gly Lys 
            740                 745                 750         


Lys Ser Glu Arg Leu Glu Leu Ser Tyr Gln Ser Val Ser Ala Glu Asn 
        755                 760                 765             


Leu Arg Leu Gln Gln Ser Leu Glu Ser Ser Ser His Lys Thr Gln Thr 
    770                 775                 780                 


Leu Glu Ser Glu Leu Gly Glu Leu Glu Ala Glu Arg Gln Ala Leu Arg 
785                 790                 795                 800 


Arg Asp Leu Glu Ala Leu Arg Leu Ala Asn Ala Gln Leu Glu Gly Ala 
                805                 810                 815     


Glu Lys Asp Arg Lys Ala Leu Glu Gln Glu Val Ala Gln Leu Glu Lys 
            820                 825                 830         


Asp Lys Lys Leu Leu Glu Lys Glu Ala Lys Arg Leu Trp Gln Gln Val 
        835                 840                 845             


Glu Leu Lys Asp Ala Val Leu Asp Asp Ser Thr Ala Lys Leu Ser Ala 
    850                 855                 860                 


Val Glu Lys Glu Ser Arg Ala Leu Asp Lys Glu Leu Ala Arg Cys Arg 
865                 870                 875                 880 


Asp Ala Ala Gly Lys Leu Lys Glu Leu Glu Lys Asp Asn Arg Asp Leu 
                885                 890                 895     


Thr Lys Gln Val Thr Val His Ala Arg Thr Leu Thr Thr Leu Arg Glu 
            900                 905                 910         


Asp Leu Val Leu Glu Lys Leu Lys Ser Gln Gln Leu Ser Ser Glu Leu 
        915                 920                 925             


Asp Lys Leu Ser Gln Glu Leu Glu Lys Val Gly Leu Asn Arg Glu Leu 
    930                 935                 940                 


Leu Leu Gln Glu Asp Asp Ser Gly Ser Asp Thr Lys Tyr Lys Ile Leu 
945                 950                 955                 960 


Glu Gly Arg Asn Glu Ser Ala Leu Lys Thr Thr Leu Ala Met Lys Glu 
                965                 970                 975     


Glu Lys Ile Val Leu Leu Glu Ala Gln Met Glu Glu Lys Ala Ser Leu 
            980                 985                 990         


Asn Arg Gln Leu Glu Ser Glu Leu  Gln Met Leu Lys Lys  Glu Cys Glu 
        995                 1000                 1005             


Thr Leu  Arg Gln Asn Gln Gly  Glu Gly Gln His Leu  Gln Asn Ser 
    1010                 1015                 1020             


Phe Lys  His Pro Ala Gly Lys  Thr Ala Ala Ser His  Gln Gly Lys 
    1025                 1030                 1035             


Glu Ala  Trp Gly Pro Gly His  Lys Glu Ala Thr Met  Glu Leu Leu 
    1040                 1045                 1050             


Arg Val  Lys Asp Arg Ala Ile  Glu Leu Glu Arg Asn  Asn Ala Ala 
    1055                 1060                 1065             


Leu Gln  Ala Glu Lys Gln Leu  Leu Lys Glu Gln Leu  Gln His Leu 
    1070                 1075                 1080             


Glu Thr  Gln Asn Val Thr Phe  Ser Ser Gln Ile Leu  Thr Leu Gln 
    1085                 1090                 1095             


Lys Gln  Ser Ala Phe Leu Gln  Glu His Asn Thr Thr  Leu Gln Thr 
    1100                 1105                 1110             


Gln Thr  Ala Lys Leu Gln Val  Glu Asn Ser Thr Leu  Ser Ser Gln 
    1115                 1120                 1125             


Ser Ala  Ala Leu Thr Ala Gln  Tyr Thr Leu Leu Gln  Asn His His 
    1130                 1135                 1140             


Thr Ala  Lys Glu Thr Glu Asn  Glu Ser Leu Gln Arg  Gln Gln Glu 
    1145                 1150                 1155             


Gln Leu  Thr Ala Ala Tyr Glu  Ala Leu Leu Gln Asp  His Glu His 
    1160                 1165                 1170             


Leu Gly  Thr Leu His Glu Arg  Gln Ser Ala Glu Tyr  Glu Ala Leu 
    1175                 1180                 1185             


Ile Arg  Gln His Ser Cys Leu  Lys Thr Leu His Arg  Asn Leu Glu 
    1190                 1195                 1200             


Leu Glu  His Lys Glu Leu Gly  Glu Arg His Gly Asp  Met Leu Lys 
    1205                 1210                 1215             


Arg Lys  Ala Glu Leu Glu Glu  Arg Glu Lys Val Leu  Thr Thr Glu 
    1220                 1225                 1230             


Arg Glu  Ala Leu Gln Gln Glu  Gln Arg Thr Asn Ala  Leu Ala Met 
    1235                 1240                 1245             


Gly Glu  Asn Gln Arg Leu Arg  Gly Glu Leu Asp Arg  Val Asn Phe 
    1250                 1255                 1260             


Leu His  His Gln Leu Lys Gly  Glu Tyr Glu Glu Leu  His Ala His 
    1265                 1270                 1275             


Thr Lys  Glu Leu Lys Thr Ser  Leu Asn Asn Ala Gln  Leu Glu Leu 
    1280                 1285                 1290             


Asn Arg  Trp Gln Ala Arg Phe  Asp Glu Leu Lys Glu  Gln His Gln 
    1295                 1300                 1305             


Thr Met  Asp Ile Ser Leu Thr  Lys Leu Asp Asn His  Cys Glu Leu 
    1310                 1315                 1320             


Leu Ser  Arg Leu Lys Gly Asn  Leu Glu Glu Glu Asn  His His Leu 
    1325                 1330                 1335             


Leu Ser  Gln Ile Gln Leu Leu  Ser Gln Gln Asn Gln  Met Leu Leu 
    1340                 1345                 1350             


Glu Gln  Asn Met Glu Asn Lys  Glu Gln Tyr His Glu  Glu Gln Lys 
    1355                 1360                 1365             


Gln Tyr  Ile Asp Lys Leu Asn  Ala Leu Arg Arg His  Lys Glu Lys 
    1370                 1375                 1380             


Leu Glu  Glu Lys Ile Met Asp  Gln Tyr Lys Phe Tyr  Asp Pro Pro 
    1385                 1390                 1395             


Pro Lys  Lys Lys Asn His Trp  Ile Gly Ala Lys Ala  Leu Val Lys 
    1400                 1405                 1410             


Leu Ile  Lys Pro Lys Lys Glu  Gly Ser Arg Glu Arg  Leu Lys Ser 
    1415                 1420                 1425             


Thr Val  Asp Ser Pro Pro Trp  Gln Leu Glu Ser Ser  Asp Pro Ala 
    1430                 1435                 1440             


Ser Pro  Ala Ala Ser Gln Pro  Leu Arg Ser Gln Ala  Glu Asn Pro 
    1445                 1450                 1455             


Asp Thr  Pro Ala Leu Gly Ser  Asn Cys Ala Glu Glu  Arg Asp Ala 
    1460                 1465                 1470             


His Asn  Gly Ser Val Gly Lys  Gly Pro Gly Asp Leu  Lys Pro Lys 
    1475                 1480                 1485             


Arg Gly  Ser Pro His Arg Gly  Ser Leu Asp Arg Thr  Asp Ala Ser 
    1490                 1495                 1500             


Thr Asp  Leu Ala Met Arg Ser  Trp Pro Ser Glu Leu  Gly Ser Arg 
    1505                 1510                 1515             


Thr Cys  Ser Thr Ser Ala Thr  Thr Thr Ala Pro Ser  Asn Ser Thr 
    1520                 1525                 1530             


Pro Ile  Ala Arg His Pro Gly  Arg Thr Lys Gly Tyr  Asn Ser Asp 
    1535                 1540                 1545             


Asp Asn  Leu Cys Glu Pro Ser  Leu Glu Phe Glu Val  Pro Asn His 
    1550                 1555                 1560             


Arg Gln  Tyr Val Ser Arg Pro  Ser Ser Leu Glu Ser  Ser Arg Asn 
    1565                 1570                 1575             


Thr Ser  Ser Asn Ser Ser Pro  Leu Asn Leu Lys Gly  Ser Ser Glu 
    1580                 1585                 1590             


Gln Leu  His Gly Arg Ser Glu  Ser Phe Ser Ser Glu  Asp Leu Ile 
    1595                 1600                 1605             


Pro Ser  Arg Asp Leu Ala Thr  Leu Pro Arg Glu Ala  Ser Thr Pro 
    1610                 1615                 1620             


Gly Arg  Asn Ala Leu Gly Arg  His Glu Tyr Pro Leu  Pro Arg Asn 
    1625                 1630                 1635             


Gly Pro  Leu Pro Gln Glu Gly  Ala Gln Lys Arg Gly  Thr Ala Pro 
    1640                 1645                 1650             


Pro Tyr  Val Gly Val Arg Pro  Cys Ser Ala Ser Pro  Ser Ser Glu 
    1655                 1660                 1665             


Met Val  Thr Leu Glu Glu Phe  Leu Glu Glu Ser Asn  Arg Ser Ser 
    1670                 1675                 1680             


Pro Thr  His Asp Thr Pro Ser  Cys Arg Asp Asp Leu  Leu Ser Asp 
    1685                 1690                 1695             


Tyr Phe  Arg Lys Ala Ser Asp  Pro Pro Ala Ile Gly  Gly Gln Pro 
    1700                 1705                 1710             


Gly Pro  Pro Ala Lys Lys Glu  Gly Ala Lys Met Pro  Thr Asn Phe 
    1715                 1720                 1725             


Val Ala  Pro Thr Val Lys Met  Ala Ala Pro Thr Ser  Glu Gly Arg 
    1730                 1735                 1740             


Pro Leu  Lys Pro Gly Gln Tyr  Val Lys Pro Asn Phe  Arg Leu Thr 
    1745                 1750                 1755             


Glu Ala  Glu Ala Pro Pro Ser  Val Ala Pro Arg Gln  Ala Gln Pro 
    1760                 1765                 1770             


Pro Gln  Ser Leu Ser Leu Gly  Arg Pro Arg Gln Ala  Pro Val Pro 
    1775                 1780                 1785             


Pro Ala  Ser His Ala Pro Ala  Ser Arg Ser Ala Ser  Leu Ser Arg 
    1790                 1795                 1800             


Ala Phe  Ser Leu Ala Ser Ala  Asp Leu Leu Arg Ala  Ser Gly Pro 
    1805                 1810                 1815             


Glu Ala  Cys Lys Gln Glu Ser  Pro Gln Lys Leu Gly  Ala Pro Glu 
    1820                 1825                 1830             


Ala Leu  Gly Gly Arg Glu Thr  Gly Ser His Thr Leu  Gln Ser Pro 
    1835                 1840                 1845             


Ala Pro  Pro Ser Ser His Ser  Leu Ala Arg Glu Arg  Thr Pro Leu 
    1850                 1855                 1860             


Val Gly  Lys Ala Gly Ser Ser  Cys Gln Gly Pro Gly  Pro Arg Ser 
    1865                 1870                 1875             


Arg Pro  Leu Asp Thr Arg Arg  Phe Ser Leu Ala Pro  Pro Lys Glu 
    1880                 1885                 1890             


Glu Arg  Leu Ala Pro Leu His  Gln Ser Ala Thr Ala  Pro Ala Ile 
    1895                 1900                 1905             


Ala Thr  Ala Gly Ala Gly Ala  Ala Ala Ala Gly Ser  Gly Ser Asn 
    1910                 1915                 1920             


Ser Gln  Leu Leu His Phe Ser  Pro Ala Ala Ala Pro  Ala Ala Arg 
    1925                 1930                 1935             


Thr Lys  Pro Lys Ala Pro Pro  Arg Ser Gly Glu Val  Ala Thr Ile 
    1940                 1945                 1950             


Thr Pro  Val Arg Ala Gly Leu  Ser Leu Ser Glu Gly  Asp Gly Val 
    1955                 1960                 1965             


Pro Gly  Gln Gly Cys Ser Glu  Gly Leu Pro Ala Lys  Ser Pro Gly 
    1970                 1975                 1980             


Arg Ser  Pro Asp Leu Ala Pro  His Leu Gly Arg Ala  Leu Glu Asp 
    1985                 1990                 1995             


Cys Ser  Arg Gly Ser Val Ser  Lys Ser Ser Pro Ala  Ser Pro Glu 
    2000                 2005                 2010             


Pro Gly  Gly Asp Pro Gln Thr  Val Trp Tyr Glu Tyr  Gly Cys Val 
    2015                 2020                 2025             


<210> 6728
<211> 1276
<212> PRT
<213> Homo sapiens

<400> 6728
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu 
            100                 105                 110         


Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser 
    130                 135                 140                 


Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln 
145                 150                 155                 160 


Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser 
                165                 170                 175     


Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu 
            180                 185                 190         


Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val 
        195                 200                 205             


Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu 
    210                 215                 220                 


Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu 
225                 230                 235                 240 


Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser 
                245                 250                 255     


Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser 
            260                 265                 270         


Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser 
        275                 280                 285             


Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His 
    290                 295                 300                 


Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu 
305                 310                 315                 320 


Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn 
                325                 330                 335     


Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val 
            340                 345                 350         


Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu 
        355                 360                 365             


Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu 
    370                 375                 380                 


Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met 
385                 390                 395                 400 


Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu 
                405                 410                 415     


Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala 
            420                 425                 430         


Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala 
        435                 440                 445             


Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr 
    450                 455                 460                 


Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn 
465                 470                 475                 480 


Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Lys Leu Ala Glu 
                485                 490                 495     


Tyr Glu Asn Leu Thr Asn Lys Leu Gln Arg Asn Leu Glu Asn Val Leu 
            500                 505                 510         


Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu 
        515                 520                 525             


Gln Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys 
    530                 535                 540                 


Arg Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu 
545                 550                 555                 560 


Tyr Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro 
                565                 570                 575     


Ser Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly 
            580                 585                 590         


Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu 
        595                 600                 605             


Leu Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys 
    610                 615                 620                 


Leu Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu 
625                 630                 635                 640 


Asp Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln 
                645                 650                 655     


Arg His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu 
            660                 665                 670         


Lys Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu 
        675                 680                 685             


Ala His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu 
    690                 695                 700                 


Gln Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg 
705                 710                 715                 720 


Leu Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala 
                725                 730                 735     


Ser Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu 
            740                 745                 750         


Glu Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu 
        755                 760                 765             


Gln Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu 
    770                 775                 780                 


Arg Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg 
785                 790                 795                 800 


Tyr Glu Ser Glu Lys Leu Gln Gln Glu Asn Ser Ile Leu Arg Asn Glu 
                805                 810                 815     


Ile Thr Thr Leu Asn Glu Glu Asp Ser Ile Ser Asn Leu Lys Leu Gly 
            820                 825                 830         


Thr Leu Asn Gly Ser Gln Glu Glu Met Trp Gln Lys Thr Glu Thr Val 
        835                 840                 845             


Lys Gln Glu Asn Ala Ala Val Gln Lys Met Val Glu Asn Leu Lys Lys 
    850                 855                 860                 


Gln Ile Ser Glu Leu Lys Ile Lys Asn Gln Gln Leu Asp Leu Glu Asn 
865                 870                 875                 880 


Thr Glu Leu Ser Gln Lys Asn Ser Gln Asn Gln Glu Lys Leu Gln Glu 
                885                 890                 895     


Leu Asn Gln Arg Leu Thr Glu Met Leu Cys Gln Lys Glu Lys Glu Pro 
            900                 905                 910         


Gly Asn Ser Ala Leu Glu Glu Arg Glu Gln Glu Lys Phe Asn Leu Lys 
        915                 920                 925             


Glu Glu Leu Glu Arg Cys Lys Val Gln Ser Ser Thr Leu Val Ser Ser 
    930                 935                 940                 


Leu Glu Ala Glu Leu Ser Glu Val Lys Ile Gln Thr His Ile Val Gln 
945                 950                 955                 960 


Gln Glu Asn His Leu Leu Lys Asp Glu Leu Glu Lys Met Lys Gln Leu 
                965                 970                 975     


His Arg Cys Pro Asp Leu Ser Asp Phe Gln Gln Lys Ile Ser Ser Val 
            980                 985                 990         


Leu Ser Tyr Asn Glu Lys Leu Leu  Lys Glu Lys Glu Ala  Leu Ser Glu 
        995                 1000                 1005             


Glu Leu  Asn Ser Cys Val Asp  Lys Leu Ala Lys Ser  Ser Leu Leu 
    1010                 1015                 1020             


Glu His  Arg Ile Ala Thr Met  Lys Gln Glu Gln Lys  Ser Trp Glu 
    1025                 1030                 1035             


His Gln  Ser Ala Ser Leu Lys  Ser Gln Leu Val Ala  Ser Gln Glu 
    1040                 1045                 1050             


Lys Val  Gln Asn Leu Glu Asp  Thr Val Gln Asn Val  Asn Leu Gln 
    1055                 1060                 1065             


Met Ser  Arg Met Lys Ser Asp  Leu Arg Val Thr Gln  Gln Glu Lys 
    1070                 1075                 1080             


Glu Ala  Leu Lys Gln Glu Val  Met Ser Leu His Lys  Gln Leu Gln 
    1085                 1090                 1095             


Asn Ala  Gly Gly Lys Ser Trp  Ala Pro Glu Ile Ala  Thr His Pro 
    1100                 1105                 1110             


Ser Gly  Leu His Asn Gln Gln  Lys Arg Leu Ser Trp  Asp Lys Leu 
    1115                 1120                 1125             


Asp His  Leu Met Asn Glu Glu  Gln Gln Leu Leu Trp  Gln Glu Asn 
    1130                 1135                 1140             


Glu Arg  Leu Gln Thr Met Val  Gln Asn Thr Lys Ala  Glu Leu Thr 
    1145                 1150                 1155             


His Ser  Arg Glu Lys Val Arg  Gln Leu Glu Ser Asn  Leu Leu Pro 
    1160                 1165                 1170             


Lys His  Gln Lys His Leu Asn  Pro Ser Gly Thr Met  Asn Pro Thr 
    1175                 1180                 1185             


Glu Gln  Glu Lys Leu Ser Leu  Lys Arg Glu Cys Asp  Gln Phe Gln 
    1190                 1195                 1200             


Lys Glu  Gln Ser Pro Ala Asn  Arg Lys Val Ser Gln  Met Asn Ser 
    1205                 1210                 1215             


Leu Glu  Gln Glu Leu Glu Thr  Ile His Leu Glu Asn  Glu Gly Leu 
    1220                 1225                 1230             


Lys Lys  Lys Gln Val Lys Leu  Asp Glu Gln Leu Met  Glu Asn Ser 
    1235                 1240                 1245             


Val Val  Gly Ser Ser Arg Glu  Gly Cys Ser Ser Leu  Pro Glu Ile 
    1250                 1255                 1260             


Val Cys  Glu Asp Ala Ala Pro  Glu Val His Cys Asp  Ala 
    1265                 1270                 1275     


<210> 6729
<211> 998
<212> PRT
<213> Homo sapiens

<400> 6729
Met Lys Asp Ser Gly Asp Ser Lys Asp Gln Gln Leu Met Val Ala Leu 
1               5                   10                  15      


Arg Val Arg Pro Ile Ser Val Ala Glu Leu Glu Glu Gly Ala Thr Leu 
            20                  25                  30          


Ile Ala His Lys Val Asp Glu Gln Met Val Val Leu Met Asp Pro Met 
        35                  40                  45              


Glu Asp Pro Asp Asp Ile Leu Arg Ala His Arg Ser Arg Glu Lys Ser 
    50                  55                  60                  


Tyr Leu Phe Asp Val Ala Phe Asp Phe Thr Ala Thr Gln Glu Met Val 
65                  70                  75                  80  


Tyr Gln Ala Thr Thr Lys Ser Leu Ile Glu Gly Val Ile Ser Gly Tyr 
                85                  90                  95      


Asn Ala Thr Val Phe Ala Tyr Gly Pro Thr Gly Cys Gly Lys Thr Tyr 
            100                 105                 110         


Thr Met Leu Gly Thr Asp Gln Glu Pro Gly Ile Tyr Val Gln Thr Leu 
        115                 120                 125             


Asn Asp Leu Phe Arg Ala Ile Glu Glu Thr Ser Asn Asp Met Glu Tyr 
    130                 135                 140                 


Glu Val Ser Met Ser Tyr Leu Glu Ile Tyr Asn Glu Met Ile Arg Asp 
145                 150                 155                 160 


Leu Leu Asn Pro Ser Leu Gly Tyr Leu Glu Leu Arg Glu Asp Ser Lys 
                165                 170                 175     


Gly Val Ile Gln Val Ala Gly Ile Thr Glu Val Ser Thr Ile Asn Ala 
            180                 185                 190         


Lys Glu Ile Met Gln Leu Leu Met Lys Gly Asn Arg Gln Arg Thr Gln 
        195                 200                 205             


Glu Pro Thr Ala Ala Asn Gln Thr Ser Ser Arg Ser His Ala Val Leu 
    210                 215                 220                 


Gln Val Thr Val Arg Gln Arg Ser Arg Val Lys Asn Ile Leu Gln Glu 
225                 230                 235                 240 


Val Arg Gln Gly Arg Leu Phe Met Ile Asp Leu Ala Gly Ser Glu Arg 
                245                 250                 255     


Ala Ser Gln Thr Gln Asn Arg Gly Gln Arg Met Lys Glu Gly Ala His 
            260                 265                 270         


Ile Asn Arg Ser Leu Leu Ala Leu Gly Asn Cys Ile Asn Ala Leu Ser 
        275                 280                 285             


Asp Lys Gly Ser Asn Lys Tyr Ile Asn Tyr Arg Asp Ser Lys Leu Thr 
    290                 295                 300                 


Arg Leu Leu Lys Asp Ser Leu Gly Gly Asn Ser Arg Thr Val Met Ile 
305                 310                 315                 320 


Ala His Ile Ser Pro Ala Ser Ser Ala Phe Glu Glu Ser Arg Asn Thr 
                325                 330                 335     


Leu Thr Tyr Ala Gly Arg Ala Lys Asn Ile Lys Thr Arg Val Lys Gln 
            340                 345                 350         


Asn Leu Leu Asn Val Ser Tyr His Ile Ala Gln Tyr Thr Ser Ile Ile 
        355                 360                 365             


Ala Asp Leu Arg Gly Glu Ile Gln Arg Leu Lys Arg Lys Ile Asp Glu 
    370                 375                 380                 


Gln Thr Gly Arg Gly Gln Ala Arg Gly Arg Gln Asp Arg Gly Asp Ile 
385                 390                 395                 400 


Arg His Ile Gln Ala Glu Val Gln Leu His Ser Gly Gln Gly Glu Lys 
                405                 410                 415     


Ala Gly Met Gly Gln Leu Arg Glu Gln Leu Ala Ser Ala Phe Gln Glu 
            420                 425                 430         


Gln Met Asp Val Arg Arg Arg Leu Leu Glu Leu Glu Asn Arg Ala Met 
        435                 440                 445             


Glu Val Gln Ile Asp Thr Ser Arg His Leu Leu Thr Ile Ala Gly Trp 
    450                 455                 460                 


Lys His Glu Lys Ser Arg Arg Ala Leu Lys Trp Arg Glu Glu Gln Arg 
465                 470                 475                 480 


Lys Glu Cys Tyr Ala Lys Asp Asp Ser Glu Lys Asp Ser Asp Thr Gly 
                485                 490                 495     


Asp Asp Gln Pro Asp Ile Leu Glu Pro Pro Glu Val Ala Ala Ala Arg 
            500                 505                 510         


Glu Ser Ile Ala Ala Leu Val Asp Glu Gln Lys Gln Leu Arg Lys Gln 
        515                 520                 525             


Lys Leu Ala Leu Glu Gln Arg Cys Arg Glu Leu Arg Ala Arg Gly Arg 
    530                 535                 540                 


Arg Leu Glu Glu Thr Leu Pro Arg Arg Ile Gly Ser Glu Glu Gln Arg 
545                 550                 555                 560 


Glu Val Leu Ser Leu Leu Cys Arg Val His Glu Leu Glu Val Glu Asn 
                565                 570                 575     


Thr Glu Met Gln Ser His Ala Leu Leu Arg Asp Gly Ala Leu Arg His 
            580                 585                 590         


Arg His Glu Ala Val Arg Arg Leu Glu Gln His Arg Ser Leu Cys Asp 
        595                 600                 605             


Glu Ile Ile Gln Gly Gln Arg Gln Ile Ile Asp Asp Tyr Asn Leu Ala 
    610                 615                 620                 


Val Pro Gln Arg Leu Glu Glu Leu Tyr Glu Val Tyr Leu Arg Glu Leu 
625                 630                 635                 640 


Glu Glu Gly Ser Leu Glu Gln Ala Thr Ile Met Asp Gln Val Ala Ser 
                645                 650                 655     


Arg Ala Leu Gln Asp Ser Ser Leu Pro Lys Ile Thr Pro Ala Gly Thr 
            660                 665                 670         


Ser Leu Thr Pro Asp Ser Asp Leu Glu Ser Val Lys Thr Leu Ser Ser 
        675                 680                 685             


Asp Ala Gln His Leu Gln Asn Ser Ala Leu Pro Pro Leu Ser Thr Glu 
    690                 695                 700                 


Ser Glu Gly His His Val Phe Lys Ala Gly Thr Gly Ala Trp Gln Ala 
705                 710                 715                 720 


Lys Ser Ser Ser Val Pro Thr Pro Pro Pro Ile Gln Leu Gly Ser Leu 
                725                 730                 735     


Val Thr Gln Glu Ala Pro Ala Gln Asp Ser Leu Gly Ser Trp Ile Asn 
            740                 745                 750         


Ser Ser Pro Asp Ser Ser Glu Asn Leu Ser Glu Ile Pro Leu Ser His 
        755                 760                 765             


Lys Glu Arg Lys Glu Ile Leu Thr Gly Thr Lys Cys Ile Trp Val Lys 
    770                 775                 780                 


Ala Ala Arg Arg Arg Ser Arg Ala Leu Gly Thr Glu Gly Arg His Leu 
785                 790                 795                 800 


Leu Ala Pro Ala Thr Glu Arg Ser Ser Leu Ser Leu His Ser Leu Ser 
                805                 810                 815     


Glu Gly Asp Asp Ala Arg Pro Pro Gly Pro Leu Ala Cys Lys Arg Pro 
            820                 825                 830         


Pro Ser Pro Thr Leu Gln His Ala Ala Ser Glu Asp Asn Leu Ser Ser 
        835                 840                 845             


Ser Thr Gly Glu Ala Pro Ser Arg Ala Val Gly His His Gly Asp Gly 
    850                 855                 860                 


Pro Arg Pro Trp Leu Arg Gly Gln Lys Lys Ser Leu Gly Lys Lys Arg 
865                 870                 875                 880 


Glu Glu Ser Leu Glu Ala Lys Arg Arg Lys Arg Arg Ser Arg Ser Phe 
                885                 890                 895     


Glu Val Thr Gly Gln Gly Leu Ser His Pro Lys Thr His Leu Leu Gly 
            900                 905                 910         


Pro His Gln Ala Glu Arg Ile Ser Asp His Arg Met Pro Val Cys Arg 
        915                 920                 925             


His Pro Ala Pro Gly Ile Arg His Leu Gly Lys Val Thr Leu Pro Leu 
    930                 935                 940                 


Ala Lys Val Lys Leu Pro Pro Ser Gln Asn Thr Gly Pro Gly Asp Ser 
945                 950                 955                 960 


Ser Pro Leu Ala Val Pro Pro Asn Pro Gly Gly Gly Ser Arg Arg Ala 
                965                 970                 975     


Thr Arg Gly Pro Arg Leu Pro His Gly Thr Ser Thr His Gly Lys Asp 
            980                 985                 990         


Gly Cys Ser Arg His Asn 
        995             


<210> 6730
<211> 397
<212> PRT
<213> Homo sapiens

<400> 6730
Met Thr Ala Glu Glu Gly Val Gln Leu Ser Gln Gln Asn Ala Lys Asp 
1               5                   10                  15      


Phe Phe Arg Val Leu Asn Leu Asn Lys Lys Cys Asp Thr Ser Lys His 
            20                  25                  30          


Lys Val Leu Val Val Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala 
        35                  40                  45              


Ala Lys Phe Asn Leu Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly 
    50                  55                  60                  


Phe Leu Lys Ser Leu Gly Val His Tyr Val Phe Asp Thr Thr Ile Ala 
65                  70                  75                  80  


Ala Asp Phe Ser Ile Leu Glu Ser Gln Lys Glu Phe Val Arg Arg Tyr 
                85                  90                  95      


Arg Gln His Ser Glu Glu Glu Arg Thr Leu Pro Met Leu Thr Ser Ala 
            100                 105                 110         


Cys Pro Gly Trp Val Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile 
        115                 120                 125             


Thr Ala His Leu Cys Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys 
145                 150                 155                 160 


Ile Phe His Val Ile Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala 
                165                 170                 175     


Leu Gln Glu Ser Leu Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp 
            180                 185                 190         


Cys Val Leu Thr Ser Gly Glu Ile Ala Gln Ile Met Glu Gln Gly Asp 
        195                 200                 205             


Leu Ser Val Arg Asp Ala Ala Val Asp Thr Leu Phe Gly Asp Leu Lys 
    210                 215                 220                 


Glu Asp Lys Val Thr Arg His Asp Gly Ala Ser Ser Asp Gly His Leu 
225                 230                 235                 240 


Ala His Ile Phe Arg His Ala Ala Lys Glu Leu Phe Asn Glu Asp Val 
                245                 250                 255     


Glu Glu Val Thr Tyr Arg Ala Leu Arg Asn Lys Asp Phe Gln Glu Val 
            260                 265                 270         


Thr Leu Glu Lys Asn Gly Glu Val Val Leu Arg Phe Ala Ala Ala Tyr 
        275                 280                 285             


Gly Phe Arg Asn Ile Gln Asn Met Ile Leu Lys Leu Lys Lys Gly Lys 
    290                 295                 300                 


Phe Pro Phe His Phe Val Glu Val Leu Ala Cys Ala Gly Gly Cys Leu 
305                 310                 315                 320 


Asn Gly Arg Gly Gln Ala Gln Thr Pro Asp Gly His Ala Asp Lys Ala 
                325                 330                 335     


Leu Leu Arg Gln Met Glu Gly Ile Tyr Ala Asp Ile Pro Val Arg Arg 
            340                 345                 350         


Pro Glu Ser Ser Ala His Val Gln Glu Leu Tyr Gln Glu Trp Leu Glu 
        355                 360                 365             


Gly Ile Asn Ser Pro Lys Ala Arg Glu Val Leu His Thr Thr Tyr Gln 
    370                 375                 380                 


Ser Gln Glu Arg Gly Thr His Ser Leu Asp Ile Lys Trp 
385                 390                 395         


<210> 6731
<211> 1200
<212> PRT
<213> Homo sapiens

<400> 6731
Met Lys Val Ala Gly Gly Leu Glu Leu Gly Ala Ala Ala Leu Leu Ser 
1               5                   10                  15      


Ala Ser Pro Arg Ala Leu Val Thr Leu Ser Thr Gly Pro Thr Cys Ser 
            20                  25                  30          


Ile Leu Pro Lys Asn Pro Leu Phe Pro Gln Asn Leu Ser Ser Gln Pro 
        35                  40                  45              


Cys Ile Lys Met Glu Gly Asp Lys Ser Leu Thr Phe Ser Ser Tyr Gly 
    50                  55                  60                  


Leu Gln Trp Cys Leu Tyr Glu Leu Asp Lys Glu Glu Phe Gln Thr Phe 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Lys Lys Ser Ser Glu Ser Thr Thr Cys Ser Ile 
                85                  90                  95      


Pro Gln Phe Glu Ile Glu Asn Ala Asn Val Glu Cys Leu Ala Leu Leu 
            100                 105                 110         


Leu His Glu Tyr Tyr Gly Ala Ser Leu Ala Trp Ala Thr Ser Ile Ser 
        115                 120                 125             


Ile Phe Glu Asn Met Asn Leu Arg Thr Leu Ser Glu Lys Ala Arg Asp 
    130                 135                 140                 


Asp Met Lys Arg His Ser Pro Glu Asp Pro Glu Ala Thr Met Thr Asp 
145                 150                 155                 160 


Gln Gly Pro Ser Lys Glu Lys Val Pro Gly Ile Ser Gln Ala Val Gln 
                165                 170                 175     


Gln Asp Ser Ala Thr Ala Ala Glu Thr Lys Glu Gln Glu Ile Ser Gln 
            180                 185                 190         


Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu Glu Gln Glu 
        195                 200                 205             


Ile Ser Gln Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu 
    210                 215                 220                 


Glu Gln Gly His Gly Gly Asp Thr Trp Asp Tyr Lys Ser His Val Met 
225                 230                 235                 240 


Thr Lys Phe Ala Glu Glu Glu Asp Val Arg Arg Ser Phe Glu Asn Thr 
                245                 250                 255     


Ala Ala Asp Trp Pro Glu Met Gln Thr Leu Ala Gly Ala Phe Asp Ser 
            260                 265                 270         


Asp Arg Trp Gly Phe Arg Pro Arg Thr Val Val Leu His Gly Lys Ser 
        275                 280                 285             


Gly Ile Gly Lys Ser Ala Leu Ala Arg Arg Ile Val Leu Cys Trp Ala 
    290                 295                 300                 


Gln Gly Gly Leu Tyr Gln Gly Met Phe Ser Tyr Val Phe Phe Leu Pro 
305                 310                 315                 320 


Val Arg Glu Met Gln Arg Lys Lys Glu Ser Ser Val Thr Glu Phe Ile 
                325                 330                 335     


Ser Arg Glu Trp Pro Asp Ser Gln Ala Pro Val Thr Glu Ile Met Ser 
            340                 345                 350         


Arg Pro Glu Arg Leu Leu Phe Ile Ile Asp Gly Phe Asp Asp Leu Gly 
        355                 360                 365             


Ser Val Leu Asn Asn Asp Thr Lys Leu Cys Lys Asp Trp Ala Glu Lys 
    370                 375                 380                 


Gln Pro Pro Phe Thr Leu Ile Arg Ser Leu Leu Arg Lys Val Leu Leu 
385                 390                 395                 400 


Pro Glu Ser Phe Leu Ile Val Thr Val Arg Asp Val Gly Thr Glu Lys 
                405                 410                 415     


Leu Lys Ser Glu Val Val Ser Pro Arg Tyr Leu Leu Val Arg Gly Ile 
            420                 425                 430         


Ser Gly Glu Gln Arg Ile His Leu Leu Leu Glu Arg Gly Ile Gly Glu 
        435                 440                 445             


His Gln Lys Thr Gln Gly Leu Arg Ala Ile Met Asn Asn Arg Glu Leu 
    450                 455                 460                 


Leu Asp Gln Cys Gln Val Pro Ala Val Gly Ser Leu Ile Cys Val Ala 
465                 470                 475                 480 


Leu Gln Leu Gln Asp Val Val Gly Glu Ser Val Ala Pro Phe Asn Gln 
                485                 490                 495     


Thr Leu Thr Gly Leu His Ala Ala Phe Val Phe His Gln Leu Thr Pro 
            500                 505                 510         


Arg Gly Val Val Arg Arg Cys Leu Asn Leu Glu Glu Arg Val Val Leu 
        515                 520                 525             


Lys Arg Phe Cys Arg Met Ala Val Glu Gly Val Trp Asn Arg Lys Ser 
    530                 535                 540                 


Val Phe Asp Gly Asp Asp Leu Met Val Gln Gly Leu Gly Glu Ser Glu 
545                 550                 555                 560 


Leu Arg Ala Leu Phe His Met Asn Ile Leu Leu Pro Asp Ser His Cys 
                565                 570                 575     


Glu Glu Tyr Tyr Thr Phe Phe His Leu Ser Leu Gln Asp Phe Cys Ala 
            580                 585                 590         


Ala Leu Tyr Tyr Val Leu Glu Gly Leu Glu Ile Glu Pro Ala Leu Cys 
        595                 600                 605             


Pro Leu Tyr Val Glu Lys Thr Lys Arg Ser Met Glu Leu Lys Gln Ala 
    610                 615                 620                 


Gly Phe His Ile His Ser Leu Trp Met Lys Arg Phe Leu Phe Gly Leu 
625                 630                 635                 640 


Val Ser Glu Asp Val Arg Arg Pro Leu Glu Val Leu Leu Gly Cys Pro 
                645                 650                 655     


Val Pro Leu Gly Val Lys Gln Lys Leu Leu His Trp Val Ser Leu Leu 
            660                 665                 670         


Gly Gln Gln Pro Asn Ala Thr Thr Pro Gly Asp Thr Leu Asp Ala Phe 
        675                 680                 685             


His Cys Leu Phe Glu Thr Gln Asp Lys Glu Phe Val Arg Leu Ala Leu 
    690                 695                 700                 


Asn Ser Phe Gln Glu Val Trp Leu Pro Ile Asn Gln Asn Leu Asp Leu 
705                 710                 715                 720 


Ile Ala Ser Ser Phe Cys Leu Gln His Cys Pro Tyr Leu Arg Lys Ile 
                725                 730                 735     


Arg Val Asp Val Lys Gly Ile Phe Pro Arg Asp Glu Ser Ala Glu Ala 
            740                 745                 750         


Cys Pro Val Val Pro Leu Trp Met Arg Asp Lys Thr Leu Ile Glu Glu 
        755                 760                 765             


Gln Trp Glu Asp Phe Cys Ser Met Leu Gly Thr His Pro His Leu Arg 
    770                 775                 780                 


Gln Leu Asp Leu Gly Ser Ser Ile Leu Thr Glu Arg Ala Met Lys Thr 
785                 790                 795                 800 


Leu Cys Ala Lys Leu Arg His Pro Thr Cys Lys Ile Gln Thr Leu Met 
                805                 810                 815     


Phe Arg Asn Ala Gln Ile Thr Pro Gly Val Gln His Leu Trp Arg Ile 
            820                 825                 830         


Val Met Ala Asn Arg Asn Leu Arg Ser Leu Asn Leu Gly Gly Thr His 
        835                 840                 845             


Leu Lys Glu Glu Asp Val Arg Met Ala Cys Glu Ala Leu Lys His Pro 
    850                 855                 860                 


Lys Cys Leu Leu Glu Ser Leu Arg Leu Asp Cys Cys Gly Leu Thr His 
865                 870                 875                 880 


Ala Cys Tyr Leu Lys Ile Ser Gln Ile Leu Thr Thr Ser Pro Ser Leu 
                885                 890                 895     


Lys Ser Leu Ser Leu Ala Gly Asn Lys Val Thr Asp Gln Gly Val Met 
            900                 905                 910         


Pro Leu Ser Asp Ala Leu Arg Val Ser Gln Cys Ala Leu Gln Lys Leu 
        915                 920                 925             


Ile Leu Glu Asp Cys Gly Ile Thr Ala Thr Gly Cys Gln Ser Leu Ala 
    930                 935                 940                 


Ser Ala Leu Val Ser Asn Arg Ser Leu Thr His Leu Cys Leu Ser Asn 
945                 950                 955                 960 


Asn Ser Leu Gly Asn Glu Gly Val Asn Leu Leu Cys Arg Ser Met Arg 
                965                 970                 975     


Leu Pro His Cys Ser Leu Gln Arg Leu Met Leu Asn Gln Cys His Leu 
            980                 985                 990         


Asp Thr Ala Gly Cys Gly Phe Leu  Ala Leu Ala Leu Met  Gly Asn Ser 
        995                 1000                 1005             


Trp Leu  Thr His Leu Ser Leu  Ser Met Asn Pro Val  Glu Asp Asn 
    1010                 1015                 1020             


Gly Val  Lys Leu Leu Cys Glu  Val Met Arg Glu Pro  Ser Cys His 
    1025                 1030                 1035             


Leu Gln  Asp Leu Glu Leu Val  Lys Cys His Leu Thr  Ala Ala Cys 
    1040                 1045                 1050             


Cys Glu  Ser Leu Ser Cys Val  Ile Ser Arg Ser Arg  His Leu Lys 
    1055                 1060                 1065             


Ser Leu  Asp Leu Thr Asp Asn  Ala Leu Gly Asp Gly  Gly Val Ala 
    1070                 1075                 1080             


Ala Leu  Cys Glu Gly Leu Lys  Gln Lys Asn Ser Val  Leu Ala Arg 
    1085                 1090                 1095             


Leu Gly  Leu Lys Ala Cys Gly  Leu Thr Ser Asp Cys  Cys Glu Ala 
    1100                 1105                 1110             


Leu Ser  Leu Ala Leu Ser Cys  Asn Arg His Leu Thr  Ser Leu Asn 
    1115                 1120                 1125             


Leu Val  Gln Asn Asn Phe Ser  Pro Lys Gly Met Met  Lys Leu Cys 
    1130                 1135                 1140             


Ser Ala  Phe Ala Cys Pro Thr  Ser Asn Leu Gln Ile  Ile Gly Leu 
    1145                 1150                 1155             


Trp Lys  Trp Gln Tyr Pro Val  Gln Ile Arg Lys Leu  Leu Glu Glu 
    1160                 1165                 1170             


Val Gln  Leu Leu Lys Pro Arg  Val Val Ile Asp Gly  Ser Trp His 
    1175                 1180                 1185             


Ser Phe  Asp Glu Asp Asp Arg  Tyr Trp Trp Lys Asn  
    1190                 1195                 1200 


<210> 6732
<211> 928
<212> PRT
<213> Homo sapiens

<400> 6732
Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys 
1               5                   10                  15      


Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Glu Gln Ser Tyr 
            20                  25                  30          


Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Ala Tyr 
        35                  40                  45              


Ser Gly Thr Pro Leu Thr Glu Glu Lys Glu Lys Ile Val Trp Val Arg 
    50                  55                  60                  


Phe Glu Asn Ala Asp Leu Asn Asp Thr Ser Arg Asn Leu Glu Phe His 
65                  70                  75                  80  


Glu Ile His Ser Thr Gly Asn Glu Pro Pro Leu Leu Ile Met Ile Gly 
                85                  90                  95      


Tyr Ser Asp Gly Met Gln Val Trp Ser Ile Pro Ile Ser Gly Glu Ala 
            100                 105                 110         


Gln Glu Leu Phe Ser Val Arg His Gly Pro Ile Arg Ala Ala Arg Ile 
        115                 120                 125             


Leu Pro Ala Pro Gln Phe Gly Ala Gln Lys Cys Asp Asn Phe Ala Glu 
    130                 135                 140                 


Lys Arg Pro Leu Leu Gly Val Cys Lys Ser Ile Gly Ser Ser Gly Thr 
145                 150                 155                 160 


Ser Pro Pro Tyr Cys Cys Val Asp Leu Tyr Ser Leu Arg Thr Gly Glu 
                165                 170                 175     


Met Val Lys Ser Ile Gln Phe Lys Thr Pro Ile Tyr Asp Leu His Cys 
            180                 185                 190         


Asn Lys Arg Ile Leu Val Val Val Leu Gln Glu Lys Ile Ala Ala Phe 
        195                 200                 205             


Asp Ser Cys Thr Phe Thr Lys Lys Phe Phe Val Thr Ser Cys Tyr Pro 
    210                 215                 220                 


Cys Pro Gly Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu 
225                 230                 235                 240 


Ala Tyr Ala Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly 
                245                 250                 255     


Ala Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala 
            260                 265                 270         


Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr 
        275                 280                 285             


Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala 
    290                 295                 300                 


Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr 
305                 310                 315                 320 


Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu 
                325                 330                 335     


Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys 
            340                 345                 350         


Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr 
        355                 360                 365             


Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His 
    370                 375                 380                 


Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His 
385                 390                 395                 400 


Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp 
                405                 410                 415     


Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe 
            420                 425                 430         


Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser 
        435                 440                 445             


Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu 
    450                 455                 460                 


Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser 
465                 470                 475                 480 


Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly 
                485                 490                 495     


Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro 
            500                 505                 510         


Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro 
        515                 520                 525             


Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg 
    530                 535                 540                 


Thr Gly Pro Tyr Leu Phe Gly Ala Gly Cys Phe Ser Ile Lys Ala Pro 
545                 550                 555                 560 


Cys Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met Gly 
                565                 570                 575     


Gly Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp Phe 
            580                 585                 590         


Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln Val 
        595                 600                 605             


Val Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val Glu 
    610                 615                 620                 


His Met Met Glu Pro Arg Pro Leu Ser Thr Ala Pro Lys Ile Ser Asp 
625                 630                 635                 640 


Asp Thr Pro Leu Glu Met Met Thr Ser Pro Arg Ala Ser Trp Thr Leu 
                645                 650                 655     


Val Arg Thr Pro Gln Trp Asn Glu Leu Gln Pro Pro Phe Asn Ala Asn 
            660                 665                 670         


His Pro Leu Leu Leu Ala Ala Asp Ala Val Gln Tyr Tyr Gln Phe Leu 
        675                 680                 685             


Leu Ala Gly Leu Val Pro Pro Gly Ser Pro Gly Pro Ile Thr Arg His 
    690                 695                 700                 


Gly Ser Tyr Asp Ser Leu Ala Ser Asp His Ser Gly Gln Glu Asp Glu 
705                 710                 715                 720 


Glu Trp Leu Ser Gln Val Glu Ile Val Thr His Thr Gly Pro His Arg 
                725                 730                 735     


Arg Leu Trp Met Gly Pro Gln Phe Gln Phe Lys Thr Ile His Pro Ser 
            740                 745                 750         


Gly Gln Thr Thr Val Ile Ser Ser Ser Ser Ser Val Leu Gln Ser His 
        755                 760                 765             


Gly Pro Ser Asp Thr Pro Gln Pro Leu Leu Asp Phe Asp Thr Asp Asp 
    770                 775                 780                 


Leu Asp Leu Asn Ser Leu Arg Ile Gln Pro Val Arg Ser Asp Pro Val 
785                 790                 795                 800 


Ser Met Pro Gly Ser Ser Arg Pro Val Ser Asp Arg Arg Gly Val Ser 
                805                 810                 815     


Thr Val Ile Asp Ala Ala Ser Gly Thr Phe Asp Arg Ser Val Thr Leu 
            820                 825                 830         


Leu Glu Val Cys Gly Ser Trp Pro Glu Gly Phe Gly Leu Arg His Met 
        835                 840                 845             


Ser Ser Met Glu His Thr Glu Glu Gly Leu Arg Glu Arg Leu Ala Asp 
    850                 855                 860                 


Ala Met Ala Glu Ser Pro Ser Arg Asp Val Val Gly Ser Gly Thr Glu 
865                 870                 875                 880 


Leu Gln Arg Glu Gly Ser Ile Glu Thr Leu Ser Asn Ser Ser Gly Ser 
                885                 890                 895     


Thr Ser Gly Ser Ile Pro Arg Asn Phe Asp Gly Tyr Arg Ser Pro Leu 
            900                 905                 910         


Pro Thr Asn Glu Ser Gln Pro Leu Ser Leu Phe Pro Thr Gly Phe Pro 
        915                 920                 925             


<210> 6733
<211> 166
<212> PRT
<213> Homo sapiens

<400> 6733
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Leu Glu Asn Cys Cys Arg Pro Ser Tyr Cys Gln Thr Thr Cys Cys Arg 
            20                  25                  30          


Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro 
        35                  40                  45              


Gln Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys His Pro Ser 
    50                  55                  60                  


Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys 
65                  70                  75                  80  


Cys Gln Pro Thr Cys Cys Arg Pro Gln Cys Cys Gln Thr Thr Cys Cys 
                85                  90                  95      


Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Arg Pro Gln Cys Cys Gln 
            100                 105                 110         


Ser Val Cys Cys Gln Pro Thr Cys Cys Cys Pro Ser Tyr Cys Val Ser 
        115                 120                 125             


Ser Cys Cys Arg Pro Gln Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr 
    130                 135                 140                 


Cys Cys Arg Pro Ser Cys Cys Val Ser Arg Cys Tyr Arg Pro His Cys 
145                 150                 155                 160 


Gly Gln Ser Leu Cys Cys 
                165     


<210> 6734
<211> 367
<212> PRT
<213> Homo sapiens

<400> 6734
Met Asp Asp Ala Ala Val Leu Lys Arg Arg Gly Tyr Leu Leu Gly Ile 
1               5                   10                  15      


Asn Leu Gly Glu Gly Ser Tyr Ala Lys Val Lys Ser Ala Tyr Ser Glu 
            20                  25                  30          


Arg Leu Lys Phe Asn Val Ala Ile Lys Ile Ile Asp Arg Lys Lys Ala 
        35                  40                  45              


Pro Ala Asp Phe Leu Glu Lys Phe Leu Pro Arg Glu Ile Glu Ile Leu 
    50                  55                  60                  


Ala Met Leu Asn His Cys Ser Ile Ile Lys Thr Tyr Glu Ile Phe Glu 
65                  70                  75                  80  


Thr Ser His Gly Lys Val Tyr Ile Val Met Glu Leu Ala Val Gln Gly 
                85                  90                  95      


Asp Leu Leu Glu Leu Ile Lys Thr Arg Gly Ala Leu His Glu Asp Glu 
            100                 105                 110         


Ala Arg Lys Lys Phe His Gln Leu Ser Leu Ala Ile Lys Tyr Cys His 
        115                 120                 125             


Asp Leu Asp Val Val His Arg Asp Leu Lys Cys Asp Asn Leu Leu Leu 
    130                 135                 140                 


Asp Lys Asp Phe Asn Ile Lys Leu Ser Asp Phe Ser Phe Ser Lys Arg 
145                 150                 155                 160 


Cys Leu Arg Asp Asp Ser Gly Arg Met Ala Leu Ser Lys Thr Phe Cys 
                165                 170                 175     


Gly Ser Pro Ala Tyr Ala Ala Pro Glu Val Leu Gln Gly Ile Pro Tyr 
            180                 185                 190         


Gln Pro Lys Val Tyr Asp Ile Trp Ser Leu Gly Val Ile Leu Tyr Ile 
        195                 200                 205             


Met Val Cys Gly Ser Met Pro Tyr Asp Asp Ser Asn Ile Lys Lys Met 
    210                 215                 220                 


Leu Arg Ile Gln Lys Glu His Arg Val Asn Phe Pro Arg Ser Lys His 
225                 230                 235                 240 


Leu Thr Gly Glu Cys Lys Asp Leu Ile Tyr His Met Leu Gln Pro Asp 
                245                 250                 255     


Val Asn Arg Arg Leu His Ile Asp Glu Ile Leu Ser His Cys Trp Met 
            260                 265                 270         


Gln Pro Lys Ala Arg Gly Ser Pro Ser Val Ala Ile Asn Lys Glu Gly 
        275                 280                 285             


Glu Ser Ser Arg Gly Thr Glu Pro Leu Trp Thr Pro Glu Pro Gly Ser 
    290                 295                 300                 


Asp Lys Lys Ser Ala Thr Lys Leu Glu Pro Glu Gly Glu Ala Gln Pro 
305                 310                 315                 320 


Gln Ala Gln Pro Glu Thr Lys Pro Glu Gly Thr Ala Met Gln Met Ser 
                325                 330                 335     


Arg Gln Ser Glu Ile Leu Gly Phe Pro Ser Lys Pro Ser Thr Met Glu 
            340                 345                 350         


Thr Glu Glu Gly Pro Pro Gln Gln Pro Pro Glu Thr Arg Ala Gln 
        355                 360                 365         


<210> 6735
<211> 90
<212> PRT
<213> Homo sapiens

<400> 6735
Met Ser His Tyr Gly Ser Tyr Tyr Gly Gly Leu Gly Tyr Ser Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          


Cys Arg Arg Gly Ser Gly Cys Gly Tyr Gly Gly Tyr Gly Tyr Gly Ser 
        35                  40                  45              


Gly Phe Gly Ser Tyr Gly Tyr Gly Ser Gly Phe Gly Gly Tyr Gly Tyr 
    50                  55                  60                  


Gly Ser Gly Phe Gly Gly Tyr Gly Tyr Gly Cys Cys Arg Pro Ser Tyr 
65                  70                  75                  80  


Asn Gly Gly Tyr Gly Phe Ser Gly Phe Tyr 
                85                  90  


<210> 6736
<211> 172
<212> PRT
<213> Homo sapiens

<400> 6736
Met Ser Tyr Asn Cys Cys Ser Arg Asn Phe Ser Ser Cys Ser His Gly 
1               5                   10                  15      


Gly Tyr Leu His Tyr Pro Gly Ser Ser Cys Gly Ser Ser Tyr Pro Ser 
            20                  25                  30          


Asn Leu Val Tyr Ser Thr Asp Leu Cys Ser Pro Ser Thr Cys Gln Leu 
        35                  40                  45              


Gly Ser Ser Leu Tyr Arg Gly Cys Gln Glu Thr Cys Trp Arg Pro Asn 
    50                  55                  60                  


Ser Cys Gln Thr Leu Cys Val Glu Ser Ser Pro Cys His Thr Ser Cys 
65                  70                  75                  80  


Tyr Tyr Pro Arg Thr His Met Leu Cys Asn Ser Cys Leu Thr Met His 
                85                  90                  95      


Val Gly Ser Arg Gly Phe Gly Ser Asn Ser Cys Cys Ser Leu Ser Cys 
            100                 105                 110         


Gly Ser Arg Ser Cys Ser Ser Leu Gly Cys Gly Ser Asn Gly Phe Arg 
        115                 120                 125             


Tyr Leu Asn Tyr Arg Ile His Thr Ser Pro Ser Gln Ser Tyr Arg Ser 
    130                 135                 140                 


Arg Phe Cys His Pro Ile Tyr Phe Pro Pro Arg Arg Trp Phe His Ser 
145                 150                 155                 160 


Ser Cys Tyr Gln Pro Phe Cys Arg Ser Gly Phe Tyr 
                165                 170         


<210> 6737
<211> 517
<212> PRT
<213> Homo sapiens

<400> 6737
Met Ser Gly Ser Cys Ser Ser Arg Lys Cys Phe Ser Val Pro Ala Thr 
1               5                   10                  15      


Ser Leu Cys Ser Thr Glu Val Ser Cys Gly Gly Pro Ile Cys Leu Pro 
            20                  25                  30          


Ser Ser Cys Gln Ser Gln Thr Trp Gln Leu Val Thr Cys Gln Asp Ser 
        35                  40                  45              


Cys Gly Ser Ser Ser Cys Gly Pro Gln Cys Arg Gln Pro Ser Cys Pro 
    50                  55                  60                  


Val Ser Ser Cys Ala Gln Pro Leu Cys Cys Asp Pro Val Ile Cys Glu 
65                  70                  75                  80  


Pro Ser Cys Ser Val Ser Ser Gly Cys Gln Pro Val Cys Cys Glu Ala 
                85                  90                  95      


Thr Thr Cys Glu Pro Ser Cys Ser Val Ser Asn Cys Tyr Gln Pro Val 
            100                 105                 110         


Cys Phe Glu Ala Thr Ile Cys Glu Pro Ser Cys Ser Val Ser Asn Cys 
        115                 120                 125             


Cys Gln Pro Val Cys Phe Glu Ala Thr Val Cys Glu Pro Ser Cys Ser 
    130                 135                 140                 


Val Ser Ser Cys Ala Gln Pro Val Cys Cys Glu Pro Ala Ile Cys Glu 
145                 150                 155                 160 


Pro Ser Cys Ser Val Ser Ser Cys Cys Gln Pro Val Gly Ser Glu Ala 
                165                 170                 175     


Thr Ser Cys Gln Pro Val Leu Cys Val Pro Thr Ser Cys Gln Pro Val 
            180                 185                 190         


Leu Cys Lys Ser Ser Cys Cys Gln Pro Val Val Cys Glu Pro Ser Cys 
        195                 200                 205             


Cys Ser Ala Val Cys Thr Leu Pro Ser Ser Cys Gln Pro Val Val Cys 
    210                 215                 220                 


Glu Pro Ser Cys Cys Gln Pro Val Cys Pro Thr Pro Thr Cys Ser Val 
225                 230                 235                 240 


Thr Ser Ser Cys Gln Ala Val Cys Cys Asp Pro Ser Pro Cys Glu Pro 
                245                 250                 255     


Ser Cys Ser Glu Ser Ser Ile Cys Gln Pro Ala Thr Cys Val Ala Leu 
            260                 265                 270         


Val Cys Glu Pro Val Cys Leu Arg Pro Val Cys Cys Val Gln Ser Ser 
        275                 280                 285             


Cys Glu Pro Pro Ser Val Pro Ser Thr Cys Gln Glu Pro Ser Cys Cys 
    290                 295                 300                 


Val Ser Ser Ile Cys Gln Pro Ile Cys Ser Glu Pro Ser Pro Cys Ser 
305                 310                 315                 320 


Pro Ala Val Cys Val Ser Ser Pro Cys Gln Pro Thr Cys Tyr Val Val 
                325                 330                 335     


Lys Arg Cys Pro Ser Val Cys Pro Glu Pro Val Ser Cys Pro Ser Thr 
            340                 345                 350         


Ser Cys Arg Pro Leu Ser Cys Ser Pro Gly Ser Ser Ala Ser Ala Ile 
        355                 360                 365             


Cys Arg Pro Thr Cys Pro Arg Thr Phe Tyr Ile Pro Ser Ser Ser Lys 
    370                 375                 380                 


Arg Pro Cys Ser Ala Thr Ile Ser Tyr Arg Pro Val Ser Arg Pro Ile 
385                 390                 395                 400 


Cys Arg Pro Ile Cys Ser Gly Leu Leu Thr Tyr Arg Gln Pro Tyr Met 
                405                 410                 415     


Thr Ser Ile Ser Tyr Arg Pro Ala Cys Tyr Arg Pro Cys Tyr Ser Ile 
            420                 425                 430         


Leu Arg Arg Pro Ala Cys Val Thr Ser Tyr Ser Cys Arg Pro Val Tyr 
        435                 440                 445             


Phe Arg Pro Ser Cys Thr Glu Ser Asp Ser Cys Lys Arg Asp Cys Lys 
    450                 455                 460                 


Lys Ser Thr Ser Ser Gln Leu Asp Cys Val Asp Thr Thr Pro Cys Lys 
465                 470                 475                 480 


Val Asp Val Ser Glu Glu Ala Pro Cys Gln Pro Thr Glu Ala Lys Pro 
                485                 490                 495     


Ile Ser Pro Thr Thr Arg Glu Ala Ala Ala Ala Gln Pro Ala Ala Ser 
            500                 505                 510         


Lys Pro Ala Asn Cys 
        515         


<210> 6738
<211> 341
<212> PRT
<213> Homo sapiens

<400> 6738
Met Ala Asp Gly Cys Cys Pro Gly Asn Thr Thr Ala Ile Pro Ala Val 
1               5                   10                  15      


Pro Thr Ile Thr Thr Tyr Pro Val Lys Gly Gly Phe Arg His Ala Leu 
            20                  25                  30          


Cys Leu Pro Ser Ser Cys His Ser Arg Met Trp Gln Leu Val Thr Cys 
        35                  40                  45              


Gln Glu Ser Cys Gln Pro Ser Ile Gly Ala Pro Ser Gly Cys Asp Pro 
    50                  55                  60                  


Ala Ser Cys Gln Pro Thr Arg Leu Pro Ala Thr Ser Cys Val Gly Phe 
65                  70                  75                  80  


Val Cys Gln Pro Met Cys Ser His Ala Ala Cys Tyr Gln Ser Gly Thr 
                85                  90                  95      


Gly Gln Ser Pro Cys Leu Val Ser Ser Cys Gln Pro Ser Cys Ser Glu 
            100                 105                 110         


Ser Thr Cys Cys Gln Glu Lys Cys Cys Asp Ala Ser Pro Cys Gln Gln 
        115                 120                 125             


Ser Ser Cys Gln Glu Ser Val Cys Met Ser Gly Ser Cys Gln Ala Ala 
    130                 135                 140                 


Cys Gly Gln Ser Val Cys Cys Asp Ala Gly Ser Cys Gln Pro Ser Cys 
145                 150                 155                 160 


Ser Glu Val Thr Ser Cys Pro Glu Thr Ser Cys Leu Pro Thr Ile Cys 
                165                 170                 175     


Thr Ala Ser Pro Cys Gln Pro Thr Trp Cys Gln Gly Ser Ser Cys Gln 
            180                 185                 190         


Pro Val Ser Gly Glu Gly Gln Pro Cys Lys Ser Thr Tyr Tyr Gln Pro 
        195                 200                 205             


Ile Cys Tyr Ile Phe Lys Pro Cys Gln Ser Ala Leu Tyr Met Pro Val 
    210                 215                 220                 


Pro Cys Gln Pro Ser Thr Cys Val Phe Ser Ser Cys Asn Thr Thr Cys 
225                 230                 235                 240 


Cys Val Pro Ser His Cys Gln Pro Pro His Cys Gln Leu Val Pro Ser 
                245                 250                 255     


Thr Cys Phe Ile Tyr Gln Pro Val Ala Asn Cys Gln Ala Pro Cys Ser 
            260                 265                 270         


Thr Lys Asn Cys Cys Lys Pro Ala Ser Cys Asp Thr Val Ile Ser Gly 
        275                 280                 285             


Gln Pro Thr Cys Asp Gly Pro Pro Ser Tyr Asn Gln Ser Gly Cys Lys 
    290                 295                 300                 


Ser Ala Cys Cys Val Thr Gly Leu Gly Thr Ser Pro Ser Ser Gly Ser 
305                 310                 315                 320 


Asn Cys Leu Pro Thr Ser Cys Gln Pro Ser Cys Glu Ser Ser Phe Cys 
                325                 330                 335     


Lys Ala Thr Leu Cys 
            340     


<210> 6739
<211> 195
<212> PRT
<213> Homo sapiens

<400> 6739
Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Ser Cys Gly 
1               5                   10                  15      


Gln Gly Leu Gly Gln Glu Ser Cys Cys Arg Pro Ser Cys Cys Gln Thr 
            20                  25                  30          


Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Ile Ser Ser 
        35                  40                  45              


Cys Cys Arg Pro Ser Cys Cys Ile Ser Ser Cys Cys Lys Pro Ser Cys 
    50                  55                  60                  


Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Ile Ser Ser Cys Cys 
65                  70                  75                  80  


Arg Pro Ser Cys Cys Ile Ser Ser Cys Cys Lys Pro Ser Cys Cys Arg 
                85                  90                  95      


Thr Thr Cys Cys Arg Pro Ser Cys Cys Ile Ser Ser Cys Cys Arg Pro 
            100                 105                 110         


Ser Cys Cys Ile Ser Ser Cys Cys Lys Pro Ser Cys Cys Gln Thr Thr 
        115                 120                 125             


Cys Cys Arg Pro Ser Cys Cys Ile Ser Ser Cys Tyr Arg Pro Gln Cys 
    130                 135                 140                 


Cys Gln Pro Ser Cys Cys Arg Pro Ala Cys Cys Ile Ser Ser Cys Cys 
145                 150                 155                 160 


His Pro Ser Cys Cys Val Ser Ser Cys Arg Cys Pro Phe Ser Cys Pro 
                165                 170                 175     


Thr Thr Cys Cys Arg Thr Thr Cys Phe His Pro Ile Cys Cys Gly Ser 
            180                 185                 190         


Ser Cys Cys 
        195 


<210> 6740
<211> 195
<212> PRT
<213> Homo sapiens

<400> 6740
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser His Gln Gly Cys Gly 
1               5                   10                  15      


Arg Asp Leu Cys Gln Glu Thr Cys Cys Arg Pro Ser Cys Cys Glu Thr 
            20                  25                  30          


Thr Cys Cys Arg Thr Thr Tyr Cys Arg Pro Ser Cys Cys Val Ser Ser 
        35                  40                  45              


Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys 
    50                  55                  60                  


Cys Arg Pro Arg Cys Cys Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys 
65                  70                  75                  80  


Val Ser Ser Cys Cys Lys Pro Gln Cys Cys Gln Ser Met Cys Cys Gln 
                85                  90                  95      


Pro Thr Cys Cys Arg Pro Arg Cys Cys Ile Ser Ser Cys Cys Arg Pro 
            100                 105                 110         


Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln Ser Val 
        115                 120                 125             


Cys Cys Gln Pro Thr Cys Cys His Pro Ser Cys Ser Ile Ser Ser Cys 
    130                 135                 140                 


Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg Pro Cys Cys Cys 
145                 150                 155                 160 


Leu Arg Pro Val Cys Gly Arg Val Ser Cys His Thr Thr Cys Tyr Arg 
                165                 170                 175     


Pro Thr Cys Val Ile Ser Ser Cys Pro Arg Pro Leu Cys Cys Ala Ser 
            180                 185                 190         


Ser Cys Cys 
        195 


<210> 6741
<211> 210
<212> PRT
<213> Homo sapiens

<400> 6741
Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Gln Asp Leu Cys Gln Glu Thr Cys Cys Arg Pro Ser Cys Cys Glu Thr 
            20                  25                  30          


Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser 
        35                  40                  45              


Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys 
    50                  55                  60                  


Ser Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Tyr 
65                  70                  75                  80  


Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln 
                85                  90                  95      


Pro Ala Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Glu Thr 
            100                 105                 110         


Thr Cys Cys His Pro Arg Cys Cys Ile Ser Ser Cys Cys Arg Pro Ser 
        115                 120                 125             


Cys Cys Val Ser Ser Cys Cys Lys Pro Gln Cys Cys Gln Ser Val Cys 
    130                 135                 140                 


Cys Gln Pro Asn Cys Cys Arg Pro Ser Cys Ser Ile Ser Ser Cys Cys 
145                 150                 155                 160 


Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg Pro Cys Cys Cys Val 
                165                 170                 175     


Arg Pro Val Cys Gly Arg Val Ser Cys His Thr Thr Cys Tyr Arg Pro 
            180                 185                 190         


Thr Cys Val Ile Ser Ser Cys Pro Arg Pro Leu Cys Cys Ala Ser Ser 
        195                 200                 205             


Cys Cys 
    210 


<210> 6742
<211> 128
<212> PRT
<213> Homo sapiens

<400> 6742
Met Thr Gly Ser Cys Cys Gly Ser Thr Leu Ser Ser Leu Ser Tyr Gly 
1               5                   10                  15      


Gly Gly Cys Cys Gln Pro Cys Cys Cys Arg Asp Pro Cys Cys Cys Arg 
            20                  25                  30          


Pro Val Thr Cys Gln Thr Thr Val Cys Arg Pro Val Thr Cys Val Pro 
        35                  40                  45              


Arg Cys Thr Arg Pro Ile Cys Glu Pro Cys Arg Arg Pro Val Cys Cys 
    50                  55                  60                  


Asp Pro Cys Ser Leu Gln Glu Gly Cys Cys Arg Pro Ile Thr Cys Cys 
65                  70                  75                  80  


Pro Ser Ser Cys Thr Ala Val Val Cys Arg Pro Cys Cys Trp Ala Thr 
                85                  90                  95      


Thr Cys Cys Gln Pro Val Ser Val Gln Ser Pro Cys Cys Arg Pro Pro 
            100                 105                 110         


Cys Gly Gln Pro Thr Pro Cys Ser Thr Thr Cys Arg Thr Ser Ser Cys 
        115                 120                 125             


<210> 6743
<211> 128
<212> PRT
<213> Homo sapiens

<400> 6743
Met Thr Gly Ser Cys Cys Gly Ser Thr Phe Ser Ser Leu Ser Tyr Gly 
1               5                   10                  15      


Gly Gly Cys Cys Gln Pro Cys Cys Cys Arg Asp Pro Cys Cys Cys Arg 
            20                  25                  30          


Pro Val Thr Cys Gln Thr Thr Val Cys Arg Pro Val Thr Cys Val Pro 
        35                  40                  45              


Arg Cys Thr Arg Pro Ile Cys Glu Pro Cys Arg Arg Pro Val Cys Cys 
    50                  55                  60                  


Asp Pro Cys Ser Leu Gln Glu Gly Cys Cys Arg Pro Ile Thr Cys Cys 
65                  70                  75                  80  


Pro Ser Ser Cys Thr Ala Val Val Cys Arg Pro Cys Cys Trp Ala Thr 
                85                  90                  95      


Thr Cys Cys Gln Pro Val Ser Val Gln Ser Pro Cys Cys Arg Pro Pro 
            100                 105                 110         


Cys Gly Gln Pro Thr Pro Cys Ser Thr Thr Cys Arg Thr Ser Ser Cys 
        115                 120                 125             


<210> 6744
<211> 98
<212> PRT
<213> Homo sapiens

<400> 6744
Met Asp Cys Cys Ala Ser Arg Gly Cys Ser Val Pro Thr Gly Pro Ala 
1               5                   10                  15      


Thr Thr Ile Cys Ser Ser Asp Lys Ser Cys Arg Cys Gly Val Cys Leu 
            20                  25                  30          


Pro Ser Thr Cys Pro His Thr Val Trp Leu Leu Glu Pro Thr Cys Cys 
        35                  40                  45              


Asp Asn Cys Pro Pro Pro Cys His Ile Pro Gln Pro Cys Val Pro Thr 
    50                  55                  60                  


Cys Phe Leu Leu Asn Ser Cys Gln Pro Thr Pro Gly Leu Glu Thr Leu 
65                  70                  75                  80  


Asn Leu Thr Thr Phe Thr Gln Pro Cys Cys Glu Pro Cys Leu Pro Arg 
                85                  90                  95      


Gly Cys 
        


<210> 6745
<211> 98
<212> PRT
<213> Homo sapiens

<400> 6745
Met Asp Cys Cys Ala Ser Arg Ser Cys Ser Val Pro Thr Gly Pro Ala 
1               5                   10                  15      


Thr Thr Ile Cys Ser Ser Asp Lys Ser Cys Arg Cys Gly Val Cys Leu 
            20                  25                  30          


Pro Ser Thr Cys Pro His Thr Val Trp Leu Leu Glu Pro Ile Cys Cys 
        35                  40                  45              


Asp Asn Cys Pro Pro Pro Cys His Ile Pro Gln Pro Cys Val Pro Thr 
    50                  55                  60                  


Cys Phe Leu Leu Asn Ser Cys Gln Pro Thr Pro Gly Leu Glu Thr Leu 
65                  70                  75                  80  


Asn Leu Thr Thr Phe Thr Gln Pro Cys Cys Glu Pro Cys Leu Pro Arg 
                85                  90                  95      


Gly Cys 
        


<210> 6746
<211> 98
<212> PRT
<213> Homo sapiens

<400> 6746
Met Tyr Cys Cys Ala Leu Arg Ser Cys Ser Val Pro Thr Gly Pro Ala 
1               5                   10                  15      


Thr Thr Phe Cys Ser Phe Asp Lys Ser Cys Arg Cys Gly Val Cys Leu 
            20                  25                  30          


Pro Ser Thr Cys Pro His Glu Ile Ser Leu Leu Gln Pro Ile Cys Cys 
        35                  40                  45              


Asp Thr Cys Pro Pro Pro Cys Cys Lys Pro Asp Thr Tyr Val Pro Thr 
    50                  55                  60                  


Cys Trp Leu Leu Asn Asn Cys His Pro Thr Pro Gly Leu Ser Gly Ile 
65                  70                  75                  80  


Asn Leu Thr Thr Tyr Val Gln Pro Gly Cys Glu Ser Pro Cys Glu Pro 
                85                  90                  95      


Arg Cys 
        


<210> 6747
<211> 96
<212> PRT
<213> Homo sapiens

<400> 6747
Met Cys His Thr Ser Cys Ser Ser Gly Cys Gln Pro Ala Cys Cys Ala 
1               5                   10                  15      


Pro Ser Pro Cys Gln Ala Ser Cys Tyr Ile Pro Val Gly Cys Gln Ser 
            20                  25                  30          


Ser Val Cys Val Pro Val Ser Phe Lys Pro Ala Val Cys Val Pro Val 
        35                  40                  45              


Arg Cys Gln Ser Ser Val Cys Val Pro Val Ser Cys Arg Pro Val Val 
    50                  55                  60                  


Tyr Ala Ala Pro Ser Cys Gln Ser Ser Gly Cys Cys Gln Pro Ser Cys 
65                  70                  75                  80  


Thr Ser Val Leu Cys Arg Pro Ile Ser Cys Ser Thr Pro Ser Cys Cys 
                85                  90                  95      


<210> 6748
<211> 112
<212> PRT
<213> Homo sapiens

<400> 6748
Met Cys His Thr Ser His Ser Ser Gly Cys Pro Met Ala Cys Pro Gly 
1               5                   10                  15      


Ser Pro Cys Cys Val Pro Ser Thr Cys Tyr Pro Pro Glu Gly Tyr Gly 
            20                  25                  30          


Thr Ser Cys Cys Cys Ser Ala Pro Cys Val Ala Leu Leu Cys Arg Pro 
        35                  40                  45              


Leu Cys Gly Val Ser Thr Cys Cys Gln Pro Ala Cys Cys Val Pro Ser 
    50                  55                  60                  


Pro Cys Gln Val Ala Cys Cys Val Pro Val Ser Cys Lys Pro Val Leu 
65                  70                  75                  80  


Cys Val Ala Ser Phe Cys Pro Thr Ser Gly Cys Cys Gln Pro Phe Cys 
                85                  90                  95      


Pro Thr Leu Val Tyr Arg Pro Val Thr Trp Ser Thr Pro Thr Gly Cys 
            100                 105                 110         


<210> 6749
<211> 221
<212> PRT
<213> Homo sapiens

<400> 6749
Met Ala Thr Ser Thr Met Ser Val Cys Ser Ser Ala Tyr Ser Asp Ser 
1               5                   10                  15      


Trp Gln Val Asp Ala Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Cys 
            20                  25                  30          


Ala Thr Ser Cys Cys Ala Pro Ala Pro Cys Leu Thr Leu Val Cys Thr 
        35                  40                  45              


Pro Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro 
    50                  55                  60                  


Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys 
65                  70                  75                  80  


Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln 
                85                  90                  95      


Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Val Pro 
            100                 105                 110         


Val Cys Cys Lys Pro Val Cys Cys Lys Pro Ile Cys Cys Val Pro Val 
        115                 120                 125             


Cys Ser Gly Ala Ser Ser Ser Cys Cys Gln Gln Ser Ser Arg Gln Pro 
    130                 135                 140                 


Ala Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu 
145                 150                 155                 160 


Leu Cys Arg Pro Val Cys Arg Ser Thr Cys Cys Val Pro Ile Pro Ser 
                165                 170                 175     


Cys Cys Ala Pro Ala Ser Thr Cys Gln Pro Ser Cys Cys Arg Pro Ala 
            180                 185                 190         


Ser Cys Val Ser Leu Leu Cys Arg Pro Thr Cys Ser Arg Leu Ser Ser 
        195                 200                 205             


Ala Cys Cys Gly Leu Ser Ser Gly Gln Lys Ser Ser Cys 
    210                 215                 220     


<210> 6750
<211> 255
<212> PRT
<213> Homo sapiens

<400> 6750
Met Ala Ala Ser Thr Met Ser Ile Cys Ser Ser Ala Cys Thr Asn Ser 
1               5                   10                  15      


Trp Gln Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Leu Pro Cys Gly 
            20                  25                  30          


Thr Pro Ser Cys Cys Ala Pro Ala Pro Cys Leu Thr Leu Val Cys Thr 
        35                  40                  45              


Pro Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro 
    50                  55                  60                  


Ser Ala Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys 
65                  70                  75                  80  


Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln 
                85                  90                  95      


Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Val Pro 
            100                 105                 110         


Val Cys Cys Gly Ala Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro 
        115                 120                 125             


Ala Cys Cys Ala Ser Ser Ser Cys Gln Gln Ser Cys Arg Val Pro Val 
    130                 135                 140                 


Cys Cys Lys Ala Val Cys Cys Val Pro Thr Cys Ser Glu Ser Ser Ser 
145                 150                 155                 160 


Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser 
                165                 170                 175     


Pro Cys Gln Gln Ser Cys Cys Val Ser Val Cys Cys Lys Pro Val Cys 
            180                 185                 190         


Cys Lys Ser Ile Cys Cys Val Pro Val Cys Ser Gly Ala Ser Ser Pro 
        195                 200                 205             


Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Cys 
    210                 215                 220                 


Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Val Cys Ser 
225                 230                 235                 240 


Arg Pro Ala Ser Cys Ser Phe Ser Ser Gly Gln Lys Ser Ser Cys 
                245                 250                 255 


<210> 6751
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6751
Met Cys Gly Ser Tyr Tyr Arg Asn Tyr Asn Gly Gly His Gly Tyr Gly 
1               5                   10                  15      


Cys Cys Gly Tyr Gly Gly Leu Gly Cys Gly Tyr Gly Gly Cys Gly Tyr 
            20                  25                  30          


Gly Cys Cys Gly Tyr Gly Gly Leu Gly Phe Gly Tyr Gly Gly Leu Asp 
        35                  40                  45              


Cys Gly Tyr Gly Gly Leu Gly Cys Gly Tyr Gly Ser Phe Cys Gly Cys 
    50                  55                  60                  


Gly Tyr Arg Gly Leu Asp Cys Gly Tyr Gly Cys Gly Tyr Gly Tyr Val 
65                  70                  75                  80  


Ser His Ser Phe Cys Gly Cys Gly Tyr Arg Cys Gly Ser Gly Tyr Gly 
                85                  90                  95      


Ser Ser Phe Gly Tyr Tyr Tyr 
            100             


<210> 6752
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 6752
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Ala Phe Thr Glu 
            100                 105                 110         


Thr Lys Gly Asn Val Ile Cys Leu Gly Lys Glu Val Phe Lys Gly Lys 
        115                 120                 125             


Lys Pro Asp Lys Asp Asn Arg Cys Arg Tyr Ile Leu Lys Thr Lys Phe 
    130                 135                 140                 


Arg Glu Met Trp Lys Ser Trp Pro Gly Asp Ser Lys Glu Val Gln Val 
145                 150                 155                 160 


Met Ala Glu Arg Tyr Lys Met Leu Ile Pro Phe Ser Asn Pro Arg Val 
                165                 170                 175     


Leu Pro Gly Pro Phe Ser Tyr Thr Val Val Leu Tyr Gly Pro Ala Gly 
            180                 185                 190         


Leu Gly Lys Thr Thr Leu Ala Gln Lys Leu Met Leu Asp Trp Ala Glu 
        195                 200                 205             


Asp Asn Leu Ile His Lys Phe Lys Tyr Ala Phe Tyr Leu Ser Cys Arg 
    210                 215                 220                 


Glu Leu Ser Arg Leu Gly Pro Cys Ser Phe Ala Glu Leu Val Phe Arg 
225                 230                 235                 240 


Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro His Ile Leu Ala Gln Ala 
                245                 250                 255     


Arg Lys Ile Leu Phe Val Ile Asp Gly Phe Asp Glu Leu Gly Ala Ala 
            260                 265                 270         


Pro Gly Ala Leu Ile Glu Asp Ile Cys Gly Asp Trp Glu Lys Lys Lys 
        275                 280                 285             


Pro Val Pro Val Leu Leu Gly Ser Leu Leu Asn Arg Val Met Leu Pro 
    290                 295                 300                 


Lys Ala Ala Leu Leu Val Thr Thr Arg Pro Arg Ala Leu Arg Asp Leu 
305                 310                 315                 320 


Arg Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val Glu Gly Phe Leu 
                325                 330                 335     


Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His Phe Gly Asp Glu Asp 
            340                 345                 350         


Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser Asn Ala Ala Leu Phe 
        355                 360                 365             


Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile Val Cys Thr Thr Leu 
    370                 375                 380                 


Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val Pro Thr Cys Leu Thr 
385                 390                 395                 400 


Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser Arg Phe Pro Gln Gly 
                405                 410                 415     


Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser Leu Leu Ala Ala Gln 
            420                 425                 430         


Gly Leu Trp Ala Gln Thr Ser Val Leu His Arg Glu Asp Leu Glu Arg 
        435                 440                 445             


Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe Leu Asp Gly Asp Ile 
    450                 455                 460                 


Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr Ser Phe Ile His Leu 
465                 470                 475                 480 


Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr Thr Leu Glu Lys Glu 
                485                 490                 495     


Glu Glu Glu Asp Arg Asp Gly His Thr Trp Asp Ile Gly Asp Val Gln 
            500                 505                 510         


Lys Leu Leu Ser Gly Val Glu Arg Leu Arg Asn Pro Asp Leu Ile Gln 
        515                 520                 525             


Ala Gly Tyr Tyr Ser Phe Gly Leu Ala Asn Glu Lys Arg Ala Lys Glu 
    530                 535                 540                 


Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro Asp Ile Lys Gln Glu 
545                 550                 555                 560 


Leu Leu Arg Cys Asp Ile Ser Cys Lys Gly Gly His Ser Thr Val Thr 
                565                 570                 575     


Asp Leu Gln Glu Leu Leu Gly Cys Leu Tyr Glu Ser Gln Glu Glu Glu 
            580                 585                 590         


Leu Val Lys Glu Val Met Ala Gln Phe Lys Glu Ile Ser Leu His Leu 
        595                 600                 605             


Asn Ala Val Asp Val Val Pro Ser Ser Phe Cys Val Lys His Cys Arg 
    610                 615                 620                 


Asn Leu Gln Lys Met Ser Leu Gln Val Ile Lys Glu Asn Leu Pro Glu 
625                 630                 635                 640 


Asn Val Thr Ala Ser Glu Ser Asp Ala Glu Val Glu Arg Ser Gln Asp 
                645                 650                 655     


Asp Gln His Met Leu Pro Phe Trp Thr Asp Leu Cys Ser Ile Phe Gly 
            660                 665                 670         


Ser Asn Lys Asp Leu Met Gly Leu Ala Ile Asn Asp Ser Phe Leu Ser 
        675                 680                 685             


Ala Ser Leu Val Arg Ile Leu Cys Glu Gln Ile Ala Ser Asp Thr Cys 
    690                 695                 700                 


His Leu Gln Arg Val Val Phe Lys Asn Ile Ser Pro Ala Asp Ala His 
705                 710                 715                 720 


Arg Asn Leu Cys Leu Ala Leu Arg Gly His Lys Thr Val Thr Tyr Leu 
                725                 730                 735     


Thr Leu Gln Gly Asn Asp Gln Asp Asp Met Phe Pro Ala Leu Cys Glu 
            740                 745                 750         


Val Leu Arg His Pro Glu Cys Asn Leu Arg Tyr Leu Gly Leu Val Ser 
        755                 760                 765             


Cys Ser Ala Thr Thr Gln Gln Trp Ala Asp Leu Ser Leu Ala Leu Glu 
    770                 775                 780                 


Val Asn Gln Ser Leu Thr Cys Val Asn Leu Ser Asp Asn Glu Leu Leu 
785                 790                 795                 800 


Asp Glu Gly Ala Lys Leu Leu Tyr Thr Thr Leu Arg His Pro Lys Cys 
                805                 810                 815     


Phe Leu Gln Arg Leu Ser Leu Glu Asn Cys His Leu Thr Glu Ala Asn 
            820                 825                 830         


Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Arg Glu Leu Thr His 
        835                 840                 845             


Leu Cys Leu Ala Lys Asn Pro Ile Gly Asn Thr Gly Val Lys Phe Leu 
    850                 855                 860                 


Cys Glu Gly Leu Arg Tyr Pro Glu Cys Lys Leu Gln Thr Leu Val Leu 
865                 870                 875                 880 


Trp Asn Cys Asp Ile Thr Ser Asp Gly Cys Cys Asp Leu Thr Lys Leu 
                885                 890                 895     


Leu Gln Glu Lys Ser Ser Leu Leu Cys Leu Asp Leu Gly Leu Asn His 
            900                 905                 910         


Ile Gly Val Lys Gly Met Lys Phe Leu Cys Glu Ala Leu Arg Lys Pro 
        915                 920                 925             


Leu Cys Asn Leu Arg Cys Leu Trp Leu Trp Gly Cys Ser Ile Pro Pro 
    930                 935                 940                 


Phe Ser Cys Glu Asp Leu Cys Ser Ala Leu Ser Cys Asn Gln Ser Leu 
945                 950                 955                 960 


Val Thr Leu Asp Leu Gly Gln Asn Pro Leu Gly Ser Ser Gly Val Lys 
                965                 970                 975     


Met Leu Phe Glu Thr Leu Thr Cys Ser Ser Gly Thr Leu Arg Thr Leu 
            980                 985                 990         


Arg Leu Lys Ile Asp Asp Phe Asn  Asp Glu Leu Asn Lys  Leu Leu Glu 
        995                 1000                 1005             


Glu Ile  Glu Glu Lys Asn Pro  Gln Leu Ile Ile Asp  Thr Glu Lys 
    1010                 1015                 1020             


His His  Pro Trp Ala Glu Arg  Pro Ser Ser His Asp  Phe Met Ile 
    1025                 1030                 1035             


<210> 6753
<211> 253
<212> PRT
<213> Homo sapiens

<400> 6753
Met Glu Leu Glu Gln Arg Glu Gly Thr Met Ala Ala Val Gly Phe Glu 
1               5                   10                  15      


Glu Phe Ser Ala Pro Pro Gly Ser Glu Leu Ala Leu Pro Pro Leu Phe 
            20                  25                  30          


Gly Gly His Ile Leu Glu Ser Glu Leu Glu Thr Glu Val Glu Phe Val 
        35                  40                  45              


Ser Gly Gly Leu Gly Gly Ser Gly Leu Arg Glu Arg Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ala Ala Arg Gly Arg Arg Arg Arg Gln Arg Glu Leu Asn Arg Arg 
65                  70                  75                  80  


Lys Tyr Gln Ala Leu Gly Arg Arg Cys Arg Glu Ile Glu Gln Val Asn 
                85                  90                  95      


Glu Arg Val Leu Asn Arg Leu His Gln Val Gln Arg Ile Thr Arg Arg 
            100                 105                 110         


Leu Gln Gln Glu Arg Arg Phe Leu Met Arg Val Leu Asp Ser Tyr Gly 
        115                 120                 125             


Asp Asp Tyr Arg Ala Ser Gln Phe Thr Ile Val Leu Glu Asp Glu Gly 
    130                 135                 140                 


Ser Gln Gly Thr Asp Ala Pro Thr Pro Gly Asn Ala Glu Asn Glu Pro 
145                 150                 155                 160 


Pro Glu Lys Glu Thr Leu Ser Pro Pro Arg Arg Thr Pro Ala Pro Pro 
                165                 170                 175     


Glu Pro Gly Ser Pro Ala Pro Gly Glu Gly Pro Ser Gly Arg Lys Arg 
            180                 185                 190         


Arg Arg Val Pro Arg Asp Gly Arg Arg Ala Gly Asn Ala Leu Thr Pro 
        195                 200                 205             


Glu Leu Ala Pro Val Gln Ile Lys Val Glu Glu Asp Phe Gly Phe Glu 
    210                 215                 220                 


Ala Asp Glu Ala Leu Asp Ser Ser Trp Val Ser Arg Gly Pro Asp Lys 
225                 230                 235                 240 


Leu Leu Pro Tyr Pro Thr Leu Ala Ser Pro Ala Ser Asp 
                245                 250             


<210> 6754
<211> 892
<212> PRT
<213> Homo sapiens

<400> 6754
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Arg Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu 
    690                 695                 700                 


His Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser 
705                 710                 715                 720 


Leu Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln 
                725                 730                 735     


Gly Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg 
            740                 745                 750         


Cys Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile 
        755                 760                 765             


Ala Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly 
    770                 775                 780                 


Phe Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys 
785                 790                 795                 800 


Arg Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala 
                805                 810                 815     


Cys Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu 
            820                 825                 830         


Leu Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu 
        835                 840                 845             


Cys Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Trp 
    850                 855                 860                 


Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala Ala 
865                 870                 875                 880 


Leu Arg Val Thr Lys Pro Tyr Leu Asp Ile Gly Cys 
                885                 890         


<210> 6755
<211> 1062
<212> PRT
<213> Homo sapiens

<400> 6755
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Arg Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu 
    690                 695                 700                 


His Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser 
705                 710                 715                 720 


Leu Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln 
                725                 730                 735     


Gly Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg 
            740                 745                 750         


Cys Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile 
        755                 760                 765             


Ala Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly 
    770                 775                 780                 


Phe Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys 
785                 790                 795                 800 


Arg Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala 
                805                 810                 815     


Cys Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu 
            820                 825                 830         


Leu Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu 
        835                 840                 845             


Cys Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu 
    850                 855                 860                 


Lys Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr 
865                 870                 875                 880 


Leu Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu 
                885                 890                 895     


Leu Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro 
            900                 905                 910         


Thr Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser 
        915                 920                 925             


Ala Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu 
    930                 935                 940                 


Arg Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp 
945                 950                 955                 960 


Leu Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu 
                965                 970                 975     


Trp Leu Asp Ser Cys Gly Leu Thr Ala Lys Ala Cys Glu Asn Leu Tyr 
            980                 985                 990         


Phe Thr Leu Gly Ile Asn Gln Thr  Leu Thr Asp Leu Tyr  Leu Thr Asn 
        995                 1000                 1005             


Asn Ala  Leu Gly Asp Thr Gly  Val Arg Leu Leu Cys  Lys Arg Leu 
    1010                 1015                 1020             


Ser His  Pro Gly Cys Lys Leu  Arg Val Leu Trp Leu  Phe Gly Met 
    1025                 1030                 1035             


Asp Leu  Asn Lys Met Thr His  Ser Arg Leu Ala Ala  Leu Arg Val 
    1040                 1045                 1050             


Thr Lys  Pro Tyr Leu Asp Ile  Gly Cys 
    1055                 1060         


<210> 6756
<211> 1004
<212> PRT
<213> Homo sapiens

<400> 6756
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Lys 
    850                 855                 860                 


Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr Leu 
865                 870                 875                 880 


Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu Leu 
                885                 890                 895     


Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro Thr 
            900                 905                 910         


Cys Lys Leu Gln Thr Leu Arg Leu Asp Ser Cys Gly Leu Thr Ala Lys 
        915                 920                 925             


Ala Cys Glu Asn Leu Tyr Phe Thr Leu Gly Ile Asn Gln Thr Leu Thr 
    930                 935                 940                 


Asp Leu Tyr Leu Thr Asn Asn Ala Leu Gly Asp Thr Gly Val Arg Leu 
945                 950                 955                 960 


Leu Cys Lys Arg Leu Ser His Pro Gly Cys Lys Leu Arg Val Leu Trp 
                965                 970                 975     


Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala Ala 
            980                 985                 990         


Leu Arg Val Thr Lys Pro Tyr Leu  Asp Ile Gly Cys 
        995                 1000                 


<210> 6757
<211> 108
<212> PRT
<213> Homo sapiens

<400> 6757
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp 
            100                 105             


<210> 6758
<211> 256
<212> PRT
<213> Homo sapiens

<400> 6758
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 6759
<211> 256
<212> PRT
<213> Homo sapiens

<400> 6759
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 6760
<211> 256
<212> PRT
<213> Homo sapiens

<400> 6760
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 6761
<211> 256
<212> PRT
<213> Homo sapiens

<400> 6761
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 6762
<211> 276
<212> PRT
<213> Homo sapiens

<400> 6762
Met Ser Phe Glu Gly Gly Asp Gly Ala Gly Pro Ala Met Leu Ala Thr 
1               5                   10                  15      


Gly Thr Ala Arg Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala 
            20                  25                  30          


Val Val Gly Ala Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu 
        35                  40                  45              


Val Leu Leu Thr Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys 
    50                  55                  60                  


Ala Tyr Ala Ala His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg 
65                  70                  75                  80  


Cys Leu His Asp Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg 
                85                  90                  95      


Pro Pro Ala Pro Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser 
            100                 105                 110         


Pro Pro Arg Pro Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp 
        115                 120                 125             


Glu Pro Thr Glu Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp 
    130                 135                 140                 


Asn Gly Gly Leu Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu 
145                 150                 155                 160 


Pro Pro Phe Cys Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu 
                165                 170                 175     


Ser Glu Glu Thr Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala 
            180                 185                 190         


Ser Ala Leu Pro Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val 
        195                 200                 205             


Pro Val Trp Gly Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp 
    210                 215                 220                 


Glu Glu Asn Gly Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala 
225                 230                 235                 240 


Ser Met Arg Ala Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe 
                245                 250                 255     


Gly Asp Leu Pro Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu 
            260                 265                 270         


Lys Arg Lys Tyr 
        275     


<210> 6763
<211> 301
<212> PRT
<213> Homo sapiens

<400> 6763
Met Thr Arg His Gly Lys Asn Cys Thr Ala Gly Ala Val Tyr Thr Tyr 
1               5                   10                  15      


His Glu Lys Lys Lys Asp Thr Ala Ala Ser Gly Tyr Gly Thr Gln Asn 
            20                  25                  30          


Ile Arg Leu Ser Arg Asp Ala Val Lys Asp Phe Asp Cys Cys Cys Leu 
        35                  40                  45              


Ser Leu Gln Pro Cys His Asp Pro Val Val Thr Pro Asp Gly Tyr Leu 
    50                  55                  60                  


Tyr Glu Arg Glu Ala Ile Leu Glu Tyr Ile Leu His Gln Lys Lys Glu 
65                  70                  75                  80  


Ile Ala Arg Gln Met Lys Ala Tyr Glu Lys Gln Arg Gly Thr Arg Arg 
                85                  90                  95      


Glu Glu Gln Lys Glu Leu Gln Arg Ala Ala Ser Gln Asp His Val Arg 
            100                 105                 110         


Gly Phe Leu Glu Lys Glu Ser Ala Ile Val Ser Arg Pro Leu Asn Pro 
        115                 120                 125             


Phe Thr Ala Lys Ala Leu Ser Gly Thr Ser Pro Asp Asp Val Gln Pro 
    130                 135                 140                 


Gly Pro Ser Val Gly Pro Pro Ser Lys Asp Lys Asp Lys Val Leu Pro 
145                 150                 155                 160 


Ser Phe Trp Ile Pro Ser Leu Thr Pro Glu Ala Lys Ala Thr Lys Leu 
                165                 170                 175     


Glu Lys Pro Ser Arg Thr Val Thr Cys Pro Met Ser Gly Lys Pro Leu 
            180                 185                 190         


Arg Met Ser Asp Leu Thr Pro Val His Phe Thr Pro Leu Asp Ser Ser 
        195                 200                 205             


Val Asp Arg Val Gly Leu Ile Thr Arg Ser Glu Arg Tyr Val Cys Ala 
    210                 215                 220                 


Val Thr Arg Asp Ser Leu Ser Asn Ala Thr Pro Cys Ala Val Leu Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Val Val Thr Leu Glu Cys Val Glu Lys Leu Ile Arg 
                245                 250                 255     


Lys Asp Met Val Asp Pro Val Thr Gly Asp Lys Leu Thr Asp Arg Asp 
            260                 265                 270         


Ile Ile Val Leu Gln Arg Gly Gly Thr Gly Phe Ala Gly Ser Gly Val 
        275                 280                 285             


Lys Leu Gln Ala Glu Lys Ser Arg Pro Val Met Gln Ala 
    290                 295                 300     


<210> 6764
<211> 203
<212> PRT
<213> Homo sapiens

<400> 6764
Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly Arg Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Arg Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Thr 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr His Phe Arg Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Arg Thr Val Arg Gly Met Leu Pro His Lys Thr Lys Arg Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Arg Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
            100                 105                 110         


Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg 
        115                 120                 125             


Leu Lys Pro Thr Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu 
    130                 135                 140                 


Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Leu Met Arg 
                165                 170                 175     


Leu Arg Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr 
            180                 185                 190         


Thr Glu Val Leu Lys Thr His Gly Leu Leu Val 
        195                 200             


<210> 6765
<211> 229
<212> PRT
<213> Homo sapiens

<400> 6765
Met Thr Cys Cys Ser Gln Val Pro Pro Arg Arg Arg Pro Ser Leu Ala 
1               5                   10                  15      


Leu Ser Pro Arg Leu Asp Cys Asn Gly Leu Asn Gly Val Pro Gly Ser 
            20                  25                  30          


Ile Trp Asp Phe Val Ser Gly Ser Phe Ser Pro Ser Pro Ser Pro Ile 
        35                  40                  45              


Leu Ser Ala Gly Pro Pro Ser Ser Ser Ser Ala Ser Pro Asn Gly Ala 
    50                  55                  60                  


Glu Leu Ala Arg Val Arg Arg Gln Leu Asp Glu Ala Lys Arg Lys Ile 
65                  70                  75                  80  


Arg Gln Trp Glu Glu Ser Trp Gln Gln Val Lys Gln Val Cys Asp Ala 
                85                  90                  95      


Trp Gln Arg Glu Ala Gln Glu Ala Lys Glu Arg Ala Arg Val Ala Asp 
            100                 105                 110         


Ser Asp Arg Gln Leu Ala Leu Gln Lys Lys Glu Glu Val Glu Ala Gln 
        115                 120                 125             


Val Lys Gln Leu Gln Glu Glu Leu Glu Gly Leu Gly Val Ala Ser Thr 
    130                 135                 140                 


Leu Pro Gly Leu Arg Gly Cys Gly Asp Ile Gly Thr Ile Pro Leu Pro 
145                 150                 155                 160 


Lys Leu His Ser Leu Gln Ser Gln Leu Arg Leu Asp Leu Glu Ala Val 
                165                 170                 175     


Asp Gly Val Ile Phe Gln Leu Arg Ala Lys Gln Cys Val Ala Cys Arg 
            180                 185                 190         


Glu Arg Ala His Gly Ala Val Leu Arg Pro Cys Gln His His Ile Leu 
        195                 200                 205             


Cys Glu Pro Cys Ala Ala Thr Ala Pro Glu Cys Pro Tyr Cys Lys Gly 
    210                 215                 220                 


Gln Pro Leu Gln Trp 
225                 


<210> 6766
<211> 760
<212> PRT
<213> Homo sapiens

<400> 6766
Met Met Glu Glu Arg Ala Ala Ala Ala Val Ala Ala Ala Ala Ser Ser 
1               5                   10                  15      


Cys Arg Pro Leu Gly Ser Gly Ala Gly Pro Gly Pro Thr Gly Ala Ala 
            20                  25                  30          


Pro Val Ser Ala Pro Ala Pro Gly Pro Gly Pro Ala Gly Lys Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Ser Pro Gly Pro Thr Ala Gly Pro Glu Pro Leu Ser 
    50                  55                  60                  


Leu Pro Gly Ile Leu His Phe Ile Gln His Glu Trp Ala Arg Phe Glu 
65                  70                  75                  80  


Ala Glu Lys Ala Arg Trp Glu Ala Glu Arg Ala Glu Leu Gln Ala Gln 
                85                  90                  95      


Val Ala Phe Leu Gln Gly Glu Arg Lys Gly Gln Glu Asn Leu Lys Thr 
            100                 105                 110         


Asp Leu Val Arg Arg Ile Lys Met Leu Glu Tyr Ala Leu Lys Gln Glu 
        115                 120                 125             


Arg Ala Lys Tyr His Lys Leu Lys Phe Gly Thr Asp Leu Asn Gln Gly 
    130                 135                 140                 


Glu Lys Lys Ala Asp Val Ser Glu Gln Val Ser Asn Gly Pro Val Glu 
145                 150                 155                 160 


Ser Val Thr Leu Glu Asn Ser Pro Leu Val Trp Lys Glu Gly Arg Gln 
                165                 170                 175     


Leu Leu Arg Gln Tyr Leu Glu Glu Val Gly Tyr Thr Asp Thr Ile Leu 
            180                 185                 190         


Asp Met Arg Ser Lys Arg Val Arg Ser Leu Leu Gly Arg Ser Leu Glu 
        195                 200                 205             


Leu Asn Gly Ala Val Glu Pro Ser Glu Gly Ala Pro Arg Ala Pro Pro 
    210                 215                 220                 


Gly Pro Ala Gly Leu Ser Gly Gly Glu Ser Leu Leu Val Lys Gln Ile 
225                 230                 235                 240 


Glu Glu Gln Ile Lys Arg Asn Ala Ala Gly Lys Asp Gly Lys Glu Arg 
                245                 250                 255     


Leu Gly Gly Ser Val Leu Gly Gln Ile Pro Phe Leu Gln Asn Cys Glu 
            260                 265                 270         


Asp Glu Asp Ser Asp Glu Asp Asp Glu Leu Asp Ser Val Gln His Lys 
        275                 280                 285             


Lys Gln Arg Val Lys Leu Pro Ser Lys Ala Leu Val Pro Glu Met Glu 
    290                 295                 300                 


Asp Glu Asp Glu Glu Asp Asp Ser Glu Asp Ala Ile Asn Glu Phe Asp 
305                 310                 315                 320 


Phe Leu Gly Ser Gly Glu Asp Gly Glu Gly Ala Pro Asp Pro Arg Arg 
                325                 330                 335     


Cys Thr Val Asp Gly Ser Pro His Glu Leu Glu Ser Arg Arg Val Lys 
            340                 345                 350         


Leu Gln Gly Ile Leu Ala Asp Leu Arg Asp Val Asp Gly Leu Pro Pro 
        355                 360                 365             


Lys Val Thr Gly Pro Pro Pro Gly Thr Pro Gln Pro Arg Pro His Glu 
    370                 375                 380                 


Gly Ser Phe Gly Phe Ser Ser Asp Val Phe Ile Met Asp Thr Ile Gly 
385                 390                 395                 400 


Gly Gly Glu Val Ser Leu Gly Asp Leu Ala Asp Leu Thr Val Thr Asn 
                405                 410                 415     


Asp Asn Asp Leu Ser Cys Asp Leu Ser Asp Ser Lys Asp Ala Phe Lys 
            420                 425                 430         


Lys Thr Trp Asn Pro Lys Phe Thr Leu Arg Ser His Tyr Asp Gly Ile 
        435                 440                 445             


Arg Ser Leu Ala Phe His His Ser Gln Ser Ala Leu Leu Thr Ala Ser 
    450                 455                 460                 


Glu Asp Gly Thr Leu Lys Leu Trp Asn Leu Gln Lys Ala Val Thr Ala 
465                 470                 475                 480 


Lys Lys Asn Ala Ala Leu Asp Val Glu Pro Ile His Ala Phe Arg Ala 
                485                 490                 495     


His Arg Gly Pro Val Leu Ala Val Ala Met Gly Ser Asn Ser Glu Tyr 
            500                 505                 510         


Cys Tyr Ser Gly Gly Ala Asp Ala Cys Ile His Ser Trp Lys Ile Pro 
        515                 520                 525             


Asp Leu Ser Met Asp Pro Tyr Asp Gly Tyr Asp Pro Ser Val Leu Ser 
    530                 535                 540                 


His Val Leu Glu Gly His Gly Asp Ala Val Trp Gly Leu Ala Phe Ser 
545                 550                 555                 560 


Pro Thr Ser Gln Arg Leu Ala Ser Cys Ser Ala Asp Gly Thr Val Arg 
                565                 570                 575     


Ile Trp Asp Pro Ser Ser Ser Ser Pro Ala Cys Leu Cys Thr Phe Pro 
            580                 585                 590         


Thr Ala Ser Glu His Gly Val Pro Thr Ser Val Ala Phe Thr Ser Thr 
        595                 600                 605             


Glu Pro Ala His Ile Val Ala Ser Phe Arg Ser Gly Asp Thr Val Leu 
    610                 615                 620                 


Tyr Asp Met Glu Val Gly Ser Ala Leu Leu Thr Leu Glu Ser Arg Gly 
625                 630                 635                 640 


Ser Ser Gly Pro Thr Gln Ile Asn Gln Val Val Ser His Pro Asn Gln 
                645                 650                 655     


Pro Leu Thr Ile Thr Ala His Asp Asp Arg Gly Ile Arg Phe Leu Asp 
            660                 665                 670         


Asn Arg Thr Gly Lys Pro Val His Ser Met Val Ala His Leu Asp Ala 
        675                 680                 685             


Val Thr Cys Leu Ala Val Asp Pro Asn Gly Ala Phe Leu Met Ser Gly 
    690                 695                 700                 


Ser His Asp Cys Ser Leu Arg Leu Trp Ser Leu Asp Asn Lys Thr Cys 
705                 710                 715                 720 


Val Gln Glu Ile Thr Ala His Arg Lys Lys His Glu Glu Ala Ile His 
                725                 730                 735     


Ala Val Ala Cys His Pro Ser Lys Ala Leu Ile Ala Ser Ala Gly Ala 
            740                 745                 750         


Asp Ala Leu Ala Lys Val Phe Val 
        755                 760 


<210> 6767
<211> 108
<212> PRT
<213> Homo sapiens

<400> 6767
Met Thr Pro Glu Glu Leu Gln Lys Arg Glu Glu Glu Glu Phe Asn Thr 
1               5                   10                  15      


Gly Pro Leu Ser Val Leu Thr Gln Ser Val Lys Asn Asn Thr Gln Val 
            20                  25                  30          


Leu Ile Asn Cys Arg Asn Asn Lys Lys Leu Leu Gly Arg Val Lys Ala 
        35                  40                  45              


Phe Asp Arg His Cys Asn Met Val Leu Glu Asn Val Lys Glu Met Trp 
    50                  55                  60                  


Thr Glu Val Pro Lys Ser Gly Lys Gly Lys Lys Lys Ser Lys Pro Val 
65                  70                  75                  80  


Asn Lys Asp Arg Tyr Ile Ser Lys Met Phe Leu Arg Gly Asp Ser Val 
                85                  90                  95      


Ile Val Val Leu Arg Asn Pro Leu Ile Ala Gly Lys 
            100                 105             


<210> 6768
<211> 424
<212> PRT
<213> Homo sapiens

<400> 6768
Met Val Gln Thr Leu Tyr Tyr Ser Ala Asp His Lys Leu Leu Asp Gly 
1               5                   10                  15      


Asn Leu Leu Asp Gly Gln Ala Glu Val Phe Gly Ser Asp Asp Asp His 
            20                  25                  30          


Ile Gln Phe Val Gln Lys Lys Pro Pro Arg Glu Asn Gly His Lys Gln 
        35                  40                  45              


Ile Ser Ser Ser Ser Thr Gly Cys Leu Ser Ser Pro Asn Ala Thr Val 
    50                  55                  60                  


Gln Ser Pro Lys His Glu Trp Lys Ile Val Ala Ser Glu Lys Thr Ser 
65                  70                  75                  80  


Asn Asn Thr Tyr Leu Cys Leu Ala Val Leu Asp Gly Ile Phe Cys Val 
                85                  90                  95      


Ile Phe Leu His Gly Arg Asn Ser Pro Gln Ser Ser Pro Thr Ser Thr 
            100                 105                 110         


Pro Lys Leu Ser Lys Ser Leu Ser Phe Glu Met Gln Gln Asp Glu Leu 
        115                 120                 125             


Ile Glu Lys Pro Met Ser Pro Met Gln Tyr Ala Arg Ser Gly Leu Gly 
    130                 135                 140                 


Thr Ala Glu Met Asn Gly Lys Leu Ile Ala Ala Gly Gly Tyr Asn Arg 
145                 150                 155                 160 


Glu Glu Cys Leu Arg Thr Val Glu Cys Tyr Asn Pro His Thr Asp His 
                165                 170                 175     


Trp Ser Phe Leu Ala Pro Met Arg Thr Pro Arg Ala Arg Phe Gln Met 
            180                 185                 190         


Ala Val Leu Met Gly Gln Leu Tyr Val Val Gly Gly Ser Asn Gly His 
        195                 200                 205             


Ser Asp Asp Leu Ser Cys Gly Glu Met Tyr Asp Ser Asn Ile Asp Asp 
    210                 215                 220                 


Trp Ile Pro Val Pro Glu Leu Arg Thr Asn Arg Cys Asn Ala Gly Val 
225                 230                 235                 240 


Cys Ala Leu Asn Gly Lys Leu Tyr Ile Val Gly Gly Ser Asp Pro Tyr 
                245                 250                 255     


Gly Gln Lys Gly Leu Lys Asn Cys Asp Val Phe Asp Pro Val Thr Lys 
            260                 265                 270         


Leu Trp Thr Ser Cys Ala Pro Leu Asn Ile Arg Arg His Gln Ser Ala 
        275                 280                 285             


Val Cys Glu Leu Gly Gly Tyr Leu Tyr Ile Ile Gly Gly Ala Glu Ser 
    290                 295                 300                 


Trp Asn Cys Leu Asn Thr Val Glu Arg Tyr Asn Pro Glu Asn Asn Thr 
305                 310                 315                 320 


Trp Thr Leu Ile Ala Pro Met Asn Val Ala Arg Arg Gly Ala Gly Val 
                325                 330                 335     


Ala Val Leu Asn Gly Lys Leu Phe Val Cys Gly Gly Phe Asp Gly Ser 
            340                 345                 350         


His Ala Ile Ser Cys Val Glu Met Tyr Asp Pro Thr Arg Asn Glu Trp 
        355                 360                 365             


Lys Met Met Gly Asn Met Thr Ser Pro Arg Ser Asn Ala Gly Ile Ala 
    370                 375                 380                 


Thr Val Gly Asn Thr Ile Tyr Ala Val Gly Gly Phe Asp Gly Asn Glu 
385                 390                 395                 400 


Phe Leu Asn Thr Val Glu Val Tyr Asn Leu Glu Ser Asn Glu Trp Ser 
                405                 410                 415     


Pro Tyr Thr Lys Ile Phe Gln Phe 
            420                 


<210> 6769
<211> 160
<212> PRT
<213> Homo sapiens

<400> 6769
Met Asn Asn Ala Arg Tyr Leu Trp Lys Arg Ile Pro Pro Ala Ile Lys 
1               5                   10                  15      


Ser Ala Asn Ser Glu Leu Gly Gly Ile Trp Ser Val Gly Gln Arg Ile 
            20                  25                  30          


Trp Gln Arg Asp Phe Pro Gly Ile Tyr Thr Thr Ile Asn Ala His Gln 
        35                  40                  45              


Trp Ser Glu Thr Val Gln Pro Ile Met Glu Ala Leu Arg Asp Ala Thr 
    50                  55                  60                  


Arg Arg Arg Ala Phe Ala Leu Val Ser Gln Ala Tyr Thr Ser Ile Ile 
65                  70                  75                  80  


Ala Asp Asp Phe Ala Ala Phe Val Gly Leu Pro Val Glu Glu Ala Val 
                85                  90                  95      


Lys Gly Ile Leu Glu Gln Gly Trp Gln Ala Asp Ser Thr Thr Arg Met 
            100                 105                 110         


Val Leu Pro Arg Lys Pro Val Ala Gly Ala Leu Asp Val Ser Phe Asn 
        115                 120                 125             


Lys Phe Ile Pro Leu Ser Glu Pro Ala Pro Val Pro Pro Ile Pro Asn 
    130                 135                 140                 


Glu Gln Gln Leu Ala Arg Leu Thr Asp Tyr Val Ala Phe Leu Glu Asn 
145                 150                 155                 160 


<210> 6770
<211> 308
<212> PRT
<213> Homo sapiens

<400> 6770
Met Met Glu Glu Ile Ser Ile Met Val Ala Tyr Asp Ala His Val Phe 
1               5                   10                  15      


Ser Gln Leu His Asp Glu Asp Phe Leu Thr Ser Leu Val Ala Ile Ser 
            20                  25                  30          


Lys Pro Arg Ser Met Val Pro Thr Lys Lys Leu Lys Lys Tyr Glu Lys 
        35                  40                  45              


Glu Tyr Gln Thr Met Arg Glu Ser Gln Leu Gln Gln Glu Asp Pro Met 
    50                  55                  60                  


Asp Arg Tyr Lys Arg Glu Asn Arg Arg Leu Gln Glu Ala Ser Met Arg 
65                  70                  75                  80  


Leu Glu Gln Glu Asn Asp Asp Leu Ala His Glu Leu Val Thr Ser Lys 
                85                  90                  95      


Ile Ala Leu Arg Asn Asp Leu Asp Gln Ala Glu Asp Lys Ala Asp Val 
            100                 105                 110         


Leu Asn Lys Glu Leu Leu Leu Thr Lys Gln Arg Leu Val Glu Thr Glu 
        115                 120                 125             


Glu Glu Lys Arg Lys Gln Glu Glu Glu Thr Ala Gln Leu Lys Glu Val 
    130                 135                 140                 


Phe Arg Lys Gln Leu Glu Lys Ala Glu Tyr Glu Ile Lys Lys Thr Thr 
145                 150                 155                 160 


Ala Ile Ile Ala Glu Tyr Lys Gln Ile Cys Ser Gln Leu Ser Thr Arg 
                165                 170                 175     


Leu Glu Lys Gln Gln Ala Ala Ser Lys Glu Glu Leu Glu Val Val Lys 
            180                 185                 190         


Gly Lys Met Met Ala Cys Lys His Cys Ser Asp Ile Phe Ser Lys Glu 
        195                 200                 205             


Gly Ala Leu Lys Leu Ala Ala Thr Gly Arg Glu Asp Gln Gly Ile Glu 
    210                 215                 220                 


Thr Asp Asp Glu Lys Asp Ser Leu Lys Lys Gln Leu Arg Glu Met Glu 
225                 230                 235                 240 


Leu Glu Leu Ala Gln Thr Lys Leu Gln Leu Val Glu Ala Lys Cys Lys 
                245                 250                 255     


Ile Gln Glu Leu Glu His Gln Arg Gly Ala Leu Met Asn Glu Ile Gln 
            260                 265                 270         


Ala Ala Lys Asn Ser Trp Phe Ser Lys Thr Leu Asn Ser Ile Lys Thr 
        275                 280                 285             


Ala Thr Gly Thr Gln Pro Leu Gln Pro Ala Pro Val Thr Gln Pro Pro 
    290                 295                 300                 


Lys Glu Ser Thr 
305             


<210> 6771
<211> 1199
<212> PRT
<213> Homo sapiens

<400> 6771
Met Ala Ser Ala Gly Thr Gln His Tyr Ser Ile Gly Leu Arg Gln Lys 
1               5                   10                  15      


Asn Ser Phe Lys Gln Ser Gly Pro Ser Gly Thr Val Pro Ala Thr Pro 
            20                  25                  30          


Pro Glu Lys Pro Ser Glu Gly Arg Val Trp Pro Gln Ala His Gln Gln 
        35                  40                  45              


Val Lys Pro Ile Trp Lys Leu Glu Lys Lys Gln Val Glu Thr Leu Ser 
    50                  55                  60                  


Ala Gly Leu Gly Pro Gly Leu Leu Gly Val Pro Pro Gln Pro Ala Tyr 
65                  70                  75                  80  


Phe Phe Cys Pro Ser Thr Leu Cys Ser Ser Gly Thr Thr Ala Val Ile 
                85                  90                  95      


Ala Gly His Ser Ser Ser Cys Tyr Leu His Ser Leu Pro Asp Leu Phe 
            100                 105                 110         


Asn Ser Thr Leu Leu Tyr Arg Arg Ser Ser Tyr Arg Gln Lys Pro Tyr 
        115                 120                 125             


Gln Gln Leu Glu Ser Phe Cys Leu Arg Ser Ser Pro Ser Glu Lys Ser 
    130                 135                 140                 


Pro Phe Ser Leu Pro Gln Lys Ser Leu Pro Val Ser Leu Thr Ala Asn 
145                 150                 155                 160 


Lys Ala Thr Ser Ser Met Val Phe Ser Met Ala Gln Pro Met Ala Ser 
                165                 170                 175     


Ser Ser Thr Glu Pro Tyr Leu Cys Leu Ala Ala Ala Gly Glu Asn Pro 
            180                 185                 190         


Ser Gly Lys Ser Leu Ala Ser Ala Ile Ser Gly Lys Ile Pro Ser Pro 
        195                 200                 205             


Leu Ser Ser Ser Tyr Lys Pro Met Leu Asn Asn Asn Ser Phe Met Trp 
    210                 215                 220                 


Pro Asn Ser Thr Pro Val Pro Leu Leu Gln Thr Thr Gln Gly Leu Lys 
225                 230                 235                 240 


Pro Val Ser Pro Pro Lys Ile Gln Pro Val Ser Trp His His Ser Gly 
                245                 250                 255     


Gly Thr Gly Asp Cys Ala Pro Gln Pro Val Asp His Lys Val Pro Lys 
            260                 265                 270         


Ser Ile Gly Thr Val Pro Ala Asp Ala Ser Ala His Ile Ala Leu Ser 
        275                 280                 285             


Thr Ala Ser Ser His Asp Thr Ser Thr Thr Ser Val Ala Ser Ser Trp 
    290                 295                 300                 


Tyr Asn Arg Asn Asn Leu Ala Met Arg Ala Glu Pro Leu Ser Cys Ala 
305                 310                 315                 320 


Leu Asp Asp Ser Ser Asp Ser Gln Asp Pro Thr Lys Glu Ile Arg Phe 
                325                 330                 335     


Thr Glu Ala Val Arg Lys Leu Thr Ala Arg Gly Phe Glu Lys Met Pro 
            340                 345                 350         


Arg Gln Gly Cys Gln Leu Glu Gln Ser Ser Phe Leu Asn Pro Ser Phe 
        355                 360                 365             


Gln Trp Asn Val Leu Asn Arg Ser Arg Arg Trp Lys Pro Pro Ala Val 
    370                 375                 380                 


Asn Gln Gln Phe Pro Gln Glu Asp Ala Gly Ser Val Arg Arg Val Leu 
385                 390                 395                 400 


Pro Gly Ala Ser Asp Thr Leu Gly Leu Asp Asn Thr Val Phe Cys Thr 
                405                 410                 415     


Lys Arg Ile Ser Ile His Leu Leu Ala Ser His Ala Ser Gly Leu Asn 
            420                 425                 430         


His Asn Pro Ala Cys Glu Ser Val Ile Asp Ser Ser Ala Phe Gly Glu 
        435                 440                 445             


Gly Lys Ala Pro Gly Pro Pro Phe Pro Gln Thr Leu Gly Ile Ala Asn 
    450                 455                 460                 


Val Ala Thr Arg Leu Ser Ser Ile Gln Leu Gly Gln Ser Glu Lys Glu 
465                 470                 475                 480 


Arg Pro Glu Glu Ala Arg Glu Leu Asp Ser Ser Asp Arg Asp Ile Ser 
                485                 490                 495     


Ser Ala Thr Asp Leu Gln Pro Asp Gln Ala Glu Thr Glu Asp Thr Glu 
            500                 505                 510         


Glu Glu Leu Val Asp Gly Leu Glu Asp Cys Cys Ser Arg Asp Glu Asn 
        515                 520                 525             


Glu Glu Glu Glu Gly Asp Ser Glu Cys Ser Ser Leu Ser Ala Val Ser 
    530                 535                 540                 


Pro Ser Glu Ser Val Ala Met Ile Ser Arg Ser Cys Met Glu Ile Leu 
545                 550                 555                 560 


Thr Lys Pro Leu Ser Asn His Glu Lys Val Val Arg Pro Ala Leu Ile 
                565                 570                 575     


Tyr Ser Leu Phe Pro Asn Val Pro Pro Thr Ile Tyr Phe Gly Thr Arg 
            580                 585                 590         


Asp Glu Arg Val Glu Lys Leu Pro Trp Glu Gln Arg Lys Leu Leu Arg 
        595                 600                 605             


Trp Lys Met Ser Thr Val Thr Pro Asn Ile Val Lys Gln Thr Ile Gly 
    610                 615                 620                 


Arg Ser His Phe Lys Ile Ser Lys Arg Asn Asp Asp Trp Leu Gly Cys 
625                 630                 635                 640 


Trp Gly His His Met Lys Ser Pro Ser Phe Arg Ser Ile Arg Glu His 
                645                 650                 655     


Gln Lys Leu Asn His Phe Pro Gly Ser Phe Gln Ile Gly Arg Lys Asp 
            660                 665                 670         


Arg Leu Trp Arg Asn Leu Ser Arg Met Gln Ser Arg Phe Gly Lys Lys 
        675                 680                 685             


Glu Phe Ser Phe Phe Pro Gln Ser Phe Ile Leu Pro Gln Asp Ala Lys 
    690                 695                 700                 


Leu Leu Arg Lys Ala Trp Glu Ser Ser Ser Arg Gln Lys Trp Ile Val 
705                 710                 715                 720 


Lys Pro Pro Ala Ser Ala Arg Gly Ile Gly Ile Gln Val Ile His Lys 
                725                 730                 735     


Trp Ser Gln Leu Pro Lys Arg Arg Pro Leu Leu Val Gln Arg Tyr Leu 
            740                 745                 750         


His Lys Pro Tyr Leu Ile Ser Gly Ser Lys Phe Asp Leu Arg Ile Tyr 
        755                 760                 765             


Val Tyr Val Thr Ser Tyr Asp Pro Leu Arg Ile Tyr Leu Phe Ser Asp 
    770                 775                 780                 


Gly Leu Val Arg Phe Ala Ser Cys Lys Tyr Ser Pro Ser Met Lys Ser 
785                 790                 795                 800 


Leu Gly Asn Lys Phe Met His Leu Thr Asn Tyr Ser Val Asn Lys Lys 
                805                 810                 815     


Asn Ala Glu Tyr Gln Ala Asn Ala Asp Glu Met Ala Cys Gln Gly His 
            820                 825                 830         


Lys Trp Ala Leu Lys Ala Leu Trp Asn Tyr Leu Ser Gln Lys Gly Val 
        835                 840                 845             


Asn Ser Asp Ala Ile Trp Glu Lys Ile Lys Asp Val Val Val Lys Thr 
    850                 855                 860                 


Ile Ile Ser Ser Glu Pro Tyr Val Thr Ser Leu Leu Lys Met Tyr Val 
865                 870                 875                 880 


Arg Arg Pro Tyr Ser Cys His Glu Leu Phe Gly Phe Asp Ile Met Leu 
                885                 890                 895     


Asp Glu Asn Leu Lys Pro Trp Val Leu Glu Val Asn Ile Ser Pro Ser 
            900                 905                 910         


Leu His Ser Ser Ser Pro Leu Asp Ile Ser Ile Lys Gly Gln Met Ile 
        915                 920                 925             


Arg Asp Leu Leu Asn Leu Ala Gly Phe Val Leu Pro Asn Ala Glu Asp 
    930                 935                 940                 


Ile Ile Ser Ser Pro Ser Ser Cys Ser Ser Ser Thr Thr Ser Leu Pro 
945                 950                 955                 960 


Thr Ser Pro Gly Asp Lys Cys Arg Met Ala Pro Glu His Val Thr Ala 
                965                 970                 975     


Gln Lys Met Lys Lys Ala Tyr Tyr Leu Thr Gln Lys Ile Pro Asp Gln 
            980                 985                 990         


Asp Phe Tyr Ala Ser Val Leu Asp  Val Leu Thr Pro Asp  Asp Val Arg 
        995                 1000                 1005             


Ile Leu  Val Glu Met Glu Asp  Glu Phe Ser Arg Arg  Gly Gln Phe 
    1010                 1015                 1020             


Glu Arg  Ile Phe Pro Ser His  Ile Ser Ser Arg Tyr  Leu Arg Phe 
    1025                 1030                 1035             


Phe Glu  Gln Pro Arg Tyr Phe  Asn Ile Leu Thr Thr  Gln Trp Glu 
    1040                 1045                 1050             


Gln Lys  Tyr His Gly Asn Lys  Leu Lys Gly Val Asp  Leu Leu Arg 
    1055                 1060                 1065             


Ser Trp  Cys Tyr Lys Gly Phe  His Met Gly Val Val  Ser Asp Ser 
    1070                 1075                 1080             


Ala Pro  Val Trp Ser Leu Pro  Thr Ser Leu Leu Thr  Ile Ser Lys 
    1085                 1090                 1095             


Asp Asp  Val Ile Leu Asn Ala  Phe Ser Lys Ser Glu  Thr Ser Lys 
    1100                 1105                 1110             


Leu Gly  Lys Gln Ser Ser Cys  Glu Val Ser Leu Leu  Leu Ser Glu 
    1115                 1120                 1125             


Asp Gly  Thr Thr Pro Lys Ser  Lys Lys Thr Gln Ala  Gly Leu Ser 
    1130                 1135                 1140             


Pro Tyr  Pro Gln Lys Pro Ser  Ser Ser Lys Asp Ser  Glu Asp Thr 
    1145                 1150                 1155             


Ser Lys  Glu Pro Ser Leu Ser  Thr Gln Thr Leu Pro  Val Ile Lys 
    1160                 1165                 1170             


Cys Ser  Gly Gln Thr Ser Arg  Leu Ser Ala Ser Ser  Thr Phe Gln 
    1175                 1180                 1185             


Ser Ile  Ser Asp Ser Leu Leu  Ala Val Ser Pro 
    1190                 1195                 


<210> 6772
<211> 778
<212> PRT
<213> Homo sapiens

<400> 6772
Arg Ile Gln Glu Gln Leu Glu Ser Ser Phe Thr Gly Leu Thr Asp Glu 
1               5                   10                  15      


Lys Val Lys Ala Tyr Leu Ser Leu His Pro Gln Val Leu Asp Glu Phe 
            20                  25                  30          


Val Ser Glu Ser Val Ser Ala Glu Thr Val Glu Lys Trp Leu Lys Arg 
        35                  40                  45              


Lys Asn Asn Lys Ser Glu Asp Glu Ser Ala Pro Lys Glu Val Ser Arg 
    50                  55                  60                  


Tyr Gln Asp Thr Asn Met Gln Gly Val Val Tyr Glu Leu Asn Ser Tyr 
65                  70                  75                  80  


Ile Glu Gln Arg Leu Asp Thr Gly Gly Asp Asn Gln Leu Leu Leu Tyr 
                85                  90                  95      


Glu Leu Ser Ser Ile Ile Lys Ile Ala Thr Lys Ala Asp Gly Phe Ala 
            100                 105                 110         


Leu Tyr Phe Leu Gly Glu Cys Asn Asn Ser Leu Cys Ile Phe Thr Pro 
        115                 120                 125             


Pro Gly Ile Lys Glu Gly Lys Pro Arg Leu Ile Pro Ala Gly Pro Ile 
    130                 135                 140                 


Thr Gln Gly Thr Thr Val Ser Ala Tyr Val Ala Lys Ser Arg Lys Thr 
145                 150                 155                 160 


Leu Leu Val Glu Asp Ile Leu Gly Asp Glu Arg Phe Pro Arg Gly Thr 
                165                 170                 175     


Gly Leu Glu Ser Gly Thr Arg Ile Gln Ser Val Leu Cys Leu Pro Ile 
            180                 185                 190         


Val Thr Ala Ile Gly Asp Leu Ile Gly Ile Leu Glu Leu Tyr Arg His 
        195                 200                 205             


Trp Gly Lys Glu Ala Phe Cys Leu Ser His Gln Glu Val Ala Thr Ala 
    210                 215                 220                 


Asn Leu Ala Trp Ala Ser Val Ala Ile His Gln Val Gln Val Cys Arg 
225                 230                 235                 240 


Gly Leu Ala Lys Gln Thr Glu Leu Asn Asp Phe Leu Leu Asp Val Ser 
                245                 250                 255     


Lys Thr Tyr Phe Asp Asn Ile Val Ala Ile Asp Ser Leu Leu Glu His 
            260                 265                 270         


Ile Met Ile Tyr Ala Lys Asn Leu Val Asn Ala Asp Arg Cys Ala Leu 
        275                 280                 285             


Phe Gln Val Asp His Lys Asn Lys Glu Leu Tyr Ser Asp Leu Phe Asp 
    290                 295                 300                 


Ile Gly Glu Glu Lys Glu Gly Lys Pro Val Phe Lys Lys Thr Lys Glu 
305                 310                 315                 320 


Ile Arg Phe Ser Ile Glu Lys Gly Ile Ala Gly Gln Val Ala Arg Thr 
                325                 330                 335     


Gly Glu Val Leu Asn Ile Pro Asp Ala Tyr Ala Asp Pro Arg Phe Asn 
            340                 345                 350         


Arg Glu Val Asp Leu Tyr Thr Gly Tyr Thr Thr Arg Asn Ile Leu Cys 
        355                 360                 365             


Met Pro Ile Val Ser Arg Gly Ser Val Ile Gly Val Val Gln Met Val 
    370                 375                 380                 


Asn Lys Ile Ser Gly Ser Ala Phe Ser Lys Thr Asp Glu Asn Asn Phe 
385                 390                 395                 400 


Lys Met Phe Ala Val Phe Cys Ala Leu Ala Leu His Cys Ala Asn Met 
                405                 410                 415     


Tyr His Arg Ile Arg His Ser Glu Cys Ile Tyr Arg Val Thr Met Glu 
            420                 425                 430         


Lys Leu Ser Tyr His Ser Ile Cys Thr Ser Glu Glu Trp Gln Gly Leu 
        435                 440                 445             


Met Gln Phe Thr Leu Pro Val Arg Leu Cys Lys Glu Ile Glu Leu Phe 
    450                 455                 460                 


His Phe Asp Ile Gly Pro Phe Glu Asn Met Trp Pro Gly Ile Phe Val 
465                 470                 475                 480 


Tyr Met Val His Arg Ser Cys Gly Thr Ser Cys Phe Glu Leu Glu Lys 
                485                 490                 495     


Leu Cys Arg Phe Ile Met Ser Val Lys Lys Asn Tyr Arg Arg Val Pro 
            500                 505                 510         


Tyr His Asn Trp Lys His Ala Val Thr Val Ala His Cys Met Tyr Ala 
        515                 520                 525             


Ile Leu Gln Asn Asn His Thr Leu Phe Thr Asp Leu Glu Arg Lys Gly 
    530                 535                 540                 


Leu Leu Ile Ala Cys Leu Cys His Asp Leu Asp His Arg Gly Phe Ser 
545                 550                 555                 560 


Asn Ser Tyr Leu Gln Lys Phe Asp His Pro Leu Ala Ala Leu Tyr Ser 
                565                 570                 575     


Thr Ser Thr Met Glu Gln His His Phe Ser Gln Thr Val Ser Ile Leu 
            580                 585                 590         


Gln Leu Glu Gly His Asn Ile Phe Ser Thr Leu Ser Ser Ser Glu Tyr 
        595                 600                 605             


Glu Gln Val Leu Glu Ile Ile Arg Lys Ala Ile Ile Ala Thr Asp Leu 
    610                 615                 620                 


Ala Leu Tyr Phe Gly Asn Arg Lys Gln Leu Glu Glu Met Tyr Gln Thr 
625                 630                 635                 640 


Gly Ser Leu Asn Leu Asn Asn Gln Ser His Arg Asp Arg Val Ile Gly 
                645                 650                 655     


Leu Met Met Thr Ala Cys Asp Leu Cys Ser Val Thr Lys Leu Trp Pro 
            660                 665                 670         


Val Thr Lys Leu Thr Ala Asn Asp Ile Tyr Ala Glu Phe Trp Ala Glu 
        675                 680                 685             


Gly Asp Glu Met Lys Lys Leu Gly Ile Gln Pro Ile Pro Met Met Asp 
    690                 695                 700                 


Arg Asp Lys Lys Asp Glu Val Pro Gln Gly Gln Leu Gly Phe Tyr Asn 
705                 710                 715                 720 


Ala Val Ala Ile Pro Cys Tyr Thr Thr Leu Thr Gln Ile Leu Pro Pro 
                725                 730                 735     


Thr Glu Pro Leu Leu Lys Ala Cys Arg Asp Asn Leu Ser Gln Trp Glu 
            740                 745                 750         


Lys Val Ile Arg Gly Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro Ser 
        755                 760                 765             


Val Ala Gln Lys Ala Ala Ala Ser Glu Asp 
    770                 775             


<210> 6773
<211> 426
<212> PRT
<213> Homo sapiens

<400> 6773
Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Glu 
            180                 185                 190         


Leu Phe Arg Ala Pro Val Leu Arg Val Met Gly Pro Arg Glu Ala Arg 
        195                 200                 205             


Gly Ala Ala Leu Gly Gly Val Val Leu Arg Cys Asp Thr Arg Leu His 
    210                 215                 220                 


Pro Gln Lys Arg Asp Thr Pro Leu Gln Phe Ala Phe Tyr Lys Tyr Ser 
225                 230                 235                 240 


Arg Ala Val Arg Arg Phe Asp Trp Gly Ala Glu Tyr Thr Val Pro Glu 
                245                 250                 255     


Pro Glu Val Glu Glu Leu Glu Ser Tyr Trp Cys Glu Ala Ala Thr Ala 
            260                 265                 270         


Thr Arg Ser Val Arg Lys Arg Ser Pro Trp Leu Gln Leu Pro Gly Pro 
        275                 280                 285             


Gly Ser Pro Leu Asp Pro Ala Ser Thr Thr Ala Pro Ala Pro Trp Ala 
    290                 295                 300                 


Ala Ala Leu Ala Pro Gly Asn Arg Pro Leu Ser Phe Arg Lys Pro Pro 
305                 310                 315                 320 


Val Ser Arg Ser Val Pro Leu Val Thr Ser Val Arg Asn Thr Thr Ser 
                325                 330                 335     


Thr Gly Leu Gln Phe Pro Ala Ser Gly Ala Pro Thr Ala Gly Pro Pro 
            340                 345                 350         


Ala Cys Ala Pro Pro Thr Pro Leu Glu Gln Ser Ala Gly Ala Leu Lys 
        355                 360                 365             


Pro Asp Val Asp Leu Leu Leu Arg Glu Met Gln Leu Leu Lys Gly Leu 
    370                 375                 380                 


Leu Ser Arg Val Val Leu Glu Leu Lys Glu Pro Gln Ala Leu Arg Glu 
385                 390                 395                 400 


Leu Arg Gly Thr Pro Glu Thr Pro Thr Ser His Phe Ala Val Ser Pro 
                405                 410                 415     


Gly Thr Pro Glu Thr Thr Pro Val Glu Ser 
            420                 425     


<210> 6774
<211> 592
<212> PRT
<213> Homo sapiens

<400> 6774
Met Asp Val Met Leu Glu Asn Tyr Cys His Leu Ile Ser Val Gly Cys 
1               5                   10                  15      


His Met Thr Lys Pro Asp Val Ile Leu Lys Leu Glu Arg Gly Glu Glu 
            20                  25                  30          


Pro Trp Thr Ser Phe Ala Gly His Thr Cys Leu Glu Glu Asn Trp Lys 
        35                  40                  45              


Ala Glu Asp Phe Leu Val Lys Phe Lys Glu His Gln Glu Lys Tyr Ser 
    50                  55                  60                  


Arg Ser Val Val Ser Ile Asn His Lys Lys Leu Val Lys Glu Lys Ser 
65                  70                  75                  80  


Lys Ile Tyr Glu Lys Thr Phe Thr Leu Gly Lys Asn Pro Val Asn Ser 
                85                  90                  95      


Lys Asn Leu Pro Pro Glu Tyr Asp Thr His Gly Arg Ile Leu Lys Asn 
            100                 105                 110         


Val Ser Glu Leu Ile Ile Ser Asn Leu Asn Pro Ala Arg Lys Arg Leu 
        115                 120                 125             


Ser Glu Tyr Asn Gly Tyr Gly Lys Ser Leu Leu Ser Thr Lys Gln Glu 
    130                 135                 140                 


Thr Thr His Pro Glu Val Lys Ser His Asn Gln Ser Ala Arg Ala Phe 
145                 150                 155                 160 


Ser His Asn Glu Val Leu Met Gln Tyr Gln Lys Thr Glu Thr Pro Ala 
                165                 170                 175     


Gln Ser Phe Gly Tyr Asn Asp Cys Glu Lys Ser Phe Leu Gln Arg Gly 
            180                 185                 190         


Gly Leu Ile Thr His Ser Arg Pro Tyr Lys Gly Glu Asn Pro Ser Val 
        195                 200                 205             


Tyr Asn Lys Lys Arg Arg Ala Thr Asn Ile Glu Lys Lys His Thr Cys 
    210                 215                 220                 


Asn Glu Cys Gly Lys Ser Phe Cys Arg Lys Ser Val Leu Ile Leu His 
225                 230                 235                 240 


Gln Gly Ile His Ser Glu Glu Lys Pro Tyr Gln Cys His Gln Cys Gly 
                245                 250                 255     


Asn Ala Phe Arg Arg Lys Ser Tyr Leu Ile Asp His Gln Arg Thr His 
            260                 265                 270         


Thr Gly Glu Lys Pro Phe Val Cys Asn Glu Cys Gly Lys Ser Phe Arg 
        275                 280                 285             


Leu Lys Thr Ala Leu Thr Asp His Gln Arg Thr His Thr Gly Glu Lys 
    290                 295                 300                 


Ser Tyr Glu Cys Leu Gln Cys Arg Asn Ala Phe Arg Leu Lys Ser His 
305                 310                 315                 320 


Leu Ile Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys 
                325                 330                 335     


Asn Asp Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu Ser Leu His 
            340                 345                 350         


Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Lys Glu Cys Gly 
        355                 360                 365             


Lys Ser Phe His Gln Lys Ala Asn Leu Thr Val His Gln Arg Thr His 
    370                 375                 380                 


Thr Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Ser 
385                 390                 395                 400 


Gln Lys Thr Thr Leu Ala Leu His Glu Lys Thr His Asn Glu Glu Lys 
                405                 410                 415     


Pro Tyr Ile Cys Ser Glu Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr 
            420                 425                 430         


Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Ser Tyr Glu Cys 
        435                 440                 445             


Pro His Cys Gly Lys Ala Phe Arg Met Lys Ser Tyr Leu Ile Asp His 
    450                 455                 460                 


His Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly 
465                 470                 475                 480 


Lys Ser Phe Ser Gln Lys Thr Asn Leu Asn Leu His Gln Arg Ile His 
                485                 490                 495     


Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ser Phe Arg 
            500                 505                 510         


Gln Lys Ala Thr Leu Thr Val His Gln Lys Ile His Thr Gly Gln Lys 
        515                 520                 525             


Ser Tyr Glu Cys Pro Gln Cys Gly Lys Ala Phe Ser Arg Lys Ser Tyr 
    530                 535                 540                 


Leu Ile His His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
545                 550                 555                 560 


Ser Glu Cys Gly Lys Cys Phe Arg Gln Lys Thr Asn Leu Ile Val His 
                565                 570                 575     


Gln Arg Thr His Thr Gly Gly Glu Asp Gly Leu Thr Gly Cys Leu Ser 
            580                 585                 590         


<210> 6775
<211> 214
<212> PRT
<213> Homo sapiens

<400> 6775
Met Glu Val Thr Gly Val Ser Ala Pro Thr Val Thr Val Phe Ile Ser 
1               5                   10                  15      


Ser Ser Leu Asn Thr Phe Arg Ser Glu Lys Arg Tyr Ser Arg Ser Leu 
            20                  25                  30          


Thr Ile Ala Glu Phe Lys Cys Lys Leu Glu Leu Leu Val Gly Ser Pro 
        35                  40                  45              


Ala Ser Cys Met Glu Leu Glu Leu Tyr Gly Val Asp Asp Lys Phe Tyr 
    50                  55                  60                  


Ser Lys Leu Asp Gln Glu Asp Ala Leu Leu Gly Ser Tyr Pro Val Asp 
65                  70                  75                  80  


Asp Gly Cys Arg Ile His Val Ile Asp His Ser Gly Ala Arg Leu Gly 
                85                  90                  95      


Glu Tyr Glu Asp Val Ser Arg Val Glu Lys Tyr Thr Ile Ser Gln Glu 
            100                 105                 110         


Ala Tyr Asp Gln Arg Gln Asp Thr Val Arg Ser Phe Leu Lys Arg Ser 
        115                 120                 125             


Lys Leu Gly Arg Tyr Asn Glu Glu Glu Arg Ala Gln Gln Glu Ala Glu 
    130                 135                 140                 


Ala Ala Gln Arg Leu Ala Glu Glu Lys Ala Gln Ala Ser Ser Ile Pro 
145                 150                 155                 160 


Val Gly Ser Arg Cys Glu Val Arg Ala Ala Gly Gln Ser Pro Arg Arg 
                165                 170                 175     


Gly Thr Val Met Tyr Val Gly Ala Trp Leu Ala Gly Pro Val Pro Gly 
            180                 185                 190         


Ser Arg Ala Pro Arg Pro Gly Gly Asn Val Gly Gly Thr Val Glu Pro 
        195                 200                 205             


Arg Arg Pro Arg Ser Ala 
    210                 


<210> 6776
<211> 62
<212> PRT
<213> Homo sapiens

<400> 6776
Met Ser Ile Gln Trp Lys Thr Arg Gln Leu Gln Ser Lys Leu His Glu 
1               5                   10                  15      


Ala Asp Ile Val Val Leu Gly Ser Pro Lys Pro Glu Glu Ile Pro Leu 
            20                  25                  30          


Thr Trp Ile Gln Pro Gly Thr Thr Val Leu Asn Cys Ser His Asp Phe 
        35                  40                  45              


Leu Ser Glu Ser Leu Ile Ile Ile Arg Arg Met Ala Ile Phe 
    50                  55                  60          


<210> 6777
<211> 422
<212> PRT
<213> Homo sapiens

<400> 6777
Met Tyr Pro Asn Pro Leu Ile Tyr Cys Thr Cys Trp Asp Pro Trp Asn 
1               5                   10                  15      


Leu Gly Pro Arg Lys Leu Ile Lys Thr Pro Gln Leu Pro Arg Lys Asn 
            20                  25                  30          


Ser Thr Gly Ser Ser Lys Leu Thr Pro Leu Val Pro Ala Pro Lys Asn 
        35                  40                  45              


His Asn Tyr Leu Gln Pro Thr Lys Pro Val Val Ser Pro Lys Met Lys 
    50                  55                  60                  


Ile His Ser Ala Arg Gln Glu Glu Thr Asn Lys Ser Phe Tyr Glu Val 
65                  70                  75                  80  


Ile Asn Val Ser Pro Gly Tyr Gln Leu Val Arg Asn Arg Glu Gln Ile 
                85                  90                  95      


Ser Val Thr Leu Gly Asp Glu Met Phe Asp Arg Lys Lys Arg Trp Glu 
            100                 105                 110         


Ser Glu Ile Pro Asp Lys Gly Arg Phe Ser Arg Thr Asn Ile Ile Ser 
        115                 120                 125             


Asp Leu Glu Glu Gln Ile Ser Glu Leu Thr Ala Ile Ile Glu Gln Met 
    130                 135                 140                 


Asn Arg Asp His Gln Ser Ala Gln Lys Leu Leu Ser Ser Glu Met Asp 
145                 150                 155                 160 


Leu Arg Cys Ala Glu Met Lys Gln Asn Phe Glu Asn Lys Asn Arg Glu 
                165                 170                 175     


Leu Lys Glu Ala His Glu Ala Glu Leu Ser Glu Leu Glu Asn Asn Tyr 
            180                 185                 190         


Lys Ala Ala Leu Lys Ala Glu Lys Leu Ala Ala Gln Glu Lys Leu Glu 
        195                 200                 205             


Glu Met Gly Lys Glu Tyr Lys Tyr Leu Lys Asn Met Phe Arg Thr Tyr 
    210                 215                 220                 


Gln Asp Ser Ile Tyr Asp Glu Met Glu Glu Lys Trp Ser Lys Gln Lys 
225                 230                 235                 240 


Ala Lys Trp Lys Lys Asp Glu Lys Phe Glu Arg Glu Asn Ile Leu Leu 
                245                 250                 255     


Gln Gln Lys Lys Lys Met Thr Lys Lys Phe Glu Met Glu Ser Gly Glu 
            260                 265                 270         


Glu Asp Lys Lys Ile Asn Glu Ser Cys Ser Ala Val Phe Glu Asn Phe 
        275                 280                 285             


Ile Gln Glu Lys Glu Glu Leu Leu Lys Gln His Gln Ser Asp Thr Leu 
    290                 295                 300                 


Gln Leu Glu Glu Leu Arg Lys Thr Lys Glu Val Met Gln Glu Glu Leu 
305                 310                 315                 320 


His Ala Gln Ala Leu Ile Leu Glu Ser Leu Asn Thr Asn Leu Tyr Tyr 
                325                 330                 335     


Thr Gln Leu Glu Leu Gln Lys Glu Lys Ala Ile Val Gly Asn Leu Glu 
            340                 345                 350         


Lys Met Leu Gln Thr Lys Phe Ala Glu Thr Glu Glu Lys Tyr Lys His 
        355                 360                 365             


Thr Ile Gln Ile Leu Thr Glu Glu Asn Ile His Leu Lys Gln Lys Ile 
    370                 375                 380                 


Ile Ser Lys Asn Glu Glu Ile Cys Glu Gly Cys Ser Gly Arg Leu Ala 
385                 390                 395                 400 


Ser Ile Thr Val Ser Lys Asp Asp Ser Asp Thr Val Gln Asp Gly Ser 
                405                 410                 415     


Lys Lys Gly Gln Glu Ser 
            420         


<210> 6778
<211> 459
<212> PRT
<213> Homo sapiens

<400> 6778
Met Val Pro Phe Gly Pro Phe Ala Phe Met Pro Gly Lys Leu Val His 
1               5                   10                  15      


Thr Asn Glu Val Thr Val Leu Leu Gly Asp Asn Trp Phe Ala Lys Cys 
            20                  25                  30          


Ser Ala Lys Gln Ala Val Gly Leu Val Glu His Arg Lys Glu His Val 
        35                  40                  45              


Arg Lys Thr Ile Asp Asp Leu Lys Lys Val Met Lys Asn Phe Glu Ser 
    50                  55                  60                  


Arg Val Glu Phe Thr Glu Asp Leu Gln Lys Met Ser Asp Ala Ala Gly 
65                  70                  75                  80  


Asp Ile Val Asp Ile Arg Glu Glu Ile Lys Cys Asp Phe Glu Phe Lys 
                85                  90                  95      


Ala Lys His Arg Ile Ala His Lys Pro His Ser Lys Pro Lys Thr Ser 
            100                 105                 110         


Asp Ile Phe Glu Ala Asp Ile Ala Asn Asp Val Lys Ser Lys Asp Leu 
        115                 120                 125             


Leu Ala Asp Lys Glu Leu Trp Ala Arg Leu Glu Glu Leu Glu Arg Gln 
    130                 135                 140                 


Glu Glu Leu Leu Gly Glu Leu Asp Ser Lys Pro Asp Thr Val Ile Ala 
145                 150                 155                 160 


Asn Gly Glu Asp Thr Thr Ser Ser Glu Glu Glu Lys Glu Asp Arg Asn 
                165                 170                 175     


Thr Asn Val Asn Ala Met His Gln Val Thr Asp Ser His Thr Pro Cys 
            180                 185                 190         


His Lys Asp Val Ala Ser Ser Glu Pro Phe Ser Gly Gln Val Asn Ser 
        195                 200                 205             


Gln Leu Asn Cys Ser Val Asn Gly Ser Ser Ser Tyr His Ser Asp Asp 
    210                 215                 220                 


Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asn Ile Asp Asp Asp 
225                 230                 235                 240 


Asp Gly Asp Asn Asp His Glu Ala Leu Gly Val Gly Asp Asn Ser Ile 
                245                 250                 255     


Pro Thr Ile Tyr Phe Ser His Thr Val Glu Pro Lys Arg Val Arg Ile 
            260                 265                 270         


Asn Thr Gly Lys Asn Thr Thr Leu Lys Phe Ser Glu Lys Lys Glu Glu 
        275                 280                 285             


Ala Lys Arg Lys Arg Lys Asn Ser Thr Gly Ser Gly His Ser Ala Gln 
    290                 295                 300                 


Glu Leu Pro Thr Ile Arg Thr Pro Ala Asp Ile Tyr Arg Ala Phe Val 
305                 310                 315                 320 


Asp Val Val Asn Gly Glu Tyr Val Pro Arg Lys Ser Ile Leu Lys Ser 
                325                 330                 335     


Arg Ser Arg Glu Asn Ser Val Cys Ser Asp Thr Ser Glu Ser Ser Ala 
            340                 345                 350         


Ala Glu Phe Asp Asp Arg Arg Gly Val Leu Arg Ser Ile Ser Cys Glu 
        355                 360                 365             


Glu Ala Thr Cys Ser Asp Thr Ser Glu Ser Ile Leu Glu Glu Glu Pro 
    370                 375                 380                 


Gln Glu Asn Gln Lys Lys Leu Leu Pro Leu Ser Val Thr Pro Glu Ala 
385                 390                 395                 400 


Phe Ser Gly Thr Val Ile Glu Lys Glu Phe Val Ser Pro Ser Leu Thr 
                405                 410                 415     


Pro Pro Pro Ala Ile Ala His Pro Ala Leu Pro Thr Ile Pro Glu Arg 
            420                 425                 430         


Lys Glu Val Leu Leu Glu Ala Ser Glu Glu Thr Gly Lys Arg Val Ser 
        435                 440                 445             


Lys Phe Lys Ala Ala Arg Leu Gln Gln Lys Asp 
    450                 455                 


<210> 6779
<211> 355
<212> PRT
<213> Homo sapiens

<400> 6779
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Leu Thr His Ser 
        35                  40                  45              


Leu Gly Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Ile Ser Lys 
    50                  55                  60                  


Ile Arg Glu Glu Tyr Pro Asp Arg Ile Met Asn Thr Phe Ser Val Met 
65                  70                  75                  80  


Pro Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn Ala Thr 
                85                  90                  95      


Leu Ser Val His Gln Leu Val Glu Asn Thr Asp Glu Thr Tyr Ser Ile 
            100                 105                 110         


Asp Asn Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr 
        115                 120                 125             


Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr Met Ser 
    130                 135                 140                 


Gly Val Thr Thr Cys Leu Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu 
145                 150                 155                 160 


Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His Phe Phe 
                165                 170                 175     


Met Pro Gly Phe Ala Pro Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg 
            180                 185                 190         


Ala Leu Thr Val Pro Glu Leu Thr Gln Gln Met Phe Asp Ser Lys Asn 
        195                 200                 205             


Met Met Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr Val Ala 
    210                 215                 220                 


Ala Ile Phe Arg Gly Arg Met Ser Met Lys Glu Val Asp Glu Gln Met 
225                 230                 235                 240 


Leu Asn Val Gln Asn Lys Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro 
                245                 250                 255     


Asn Asn Val Lys Thr Ala Val Cys Asp Ile Pro Pro Arg Gly Leu Lys 
            260                 265                 270         


Met Ser Ala Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe 
        275                 280                 285             


Lys Arg Ile Ser Glu Gln Phe Thr Ala Met Phe Arg Arg Lys Ala Phe 
    290                 295                 300                 


Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met Glu Phe Thr Glu 
305                 310                 315                 320 


Ala Glu Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln 
                325                 330                 335     


Asp Ala Thr Ala Asp Glu Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu 
            340                 345                 350         


Asp Glu Ala 
        355 


<210> 6780
<211> 84
<212> PRT
<213> Homo sapiens

<400> 6780
Met Lys Val Lys Ile Lys Cys Trp Asn Gly Val Ala Thr Trp Leu Trp 
1               5                   10                  15      


Val Ala Asn Asp Glu Asn Cys Gly Ile Cys Arg Met Ala Phe Asn Gly 
            20                  25                  30          


Cys Cys Pro Asp Cys Lys Val Pro Gly Asp Asp Cys Pro Leu Val Trp 
        35                  40                  45              


Gly Gln Cys Ser His Cys Phe His Met His Cys Ile Leu Lys Trp Leu 
    50                  55                  60                  


His Ala Gln Gln Val Gln Gln His Cys Pro Met Cys Arg Gln Glu Trp 
65                  70                  75                  80  


Lys Phe Lys Glu 
                


<210> 6781
<211> 471
<212> PRT
<213> Homo sapiens

<400> 6781
Met Lys Met Gln Val Phe Cys Lys Ser Ile Glu Asp Met Thr Val Lys 
1               5                   10                  15      


Ala Glu Gln Ser Gln Gln Glu Ala Ala Lys Lys His Glu Glu Glu Lys 
            20                  25                  30          


Lys Glu Leu Glu Arg Lys Leu Ser Asp Leu Glu Lys Lys Met Glu Thr 
        35                  40                  45              


Ser His Asn Gln Cys Gln Glu Leu Lys Ala Arg Tyr Glu Arg Ala Thr 
    50                  55                  60                  


Ser Glu Thr Lys Thr Lys His Glu Glu Ile Leu Gln Asn Leu Gln Lys 
65                  70                  75                  80  


Thr Leu Leu Asp Thr Glu Asp Lys Leu Lys Gly Ala Arg Glu Glu Asn 
                85                  90                  95      


Ser Gly Leu Leu Gln Glu Leu Glu Glu Leu Arg Lys Gln Ala Asp Lys 
            100                 105                 110         


Ala Lys Ala Ala Gln Thr Ala Glu Asp Ala Met Gln Ile Met Glu Gln 
        115                 120                 125             


Met Thr Lys Glu Lys Thr Glu Thr Leu Ala Ser Leu Glu Asp Thr Lys 
    130                 135                 140                 


Gln Thr Asn Ala Lys Leu Gln Asn Glu Leu Asp Thr Leu Lys Glu Asn 
145                 150                 155                 160 


Asn Leu Lys Asn Val Glu Glu Leu Asn Lys Ser Lys Glu Leu Leu Thr 
                165                 170                 175     


Val Glu Asn Gln Lys Met Glu Glu Phe Arg Lys Glu Ile Glu Thr Leu 
            180                 185                 190         


Lys Gln Ala Ala Ala Gln Lys Ser Gln Gln Leu Ser Ala Leu Gln Glu 
        195                 200                 205             


Glu Asn Val Lys Leu Ala Glu Glu Leu Gly Arg Ser Arg Asp Glu Val 
    210                 215                 220                 


Thr Ser His Gln Lys Leu Glu Glu Glu Arg Ser Val Leu Asn Asn Gln 
225                 230                 235                 240 


Leu Leu Glu Met Lys Lys Arg Glu Ser Lys Phe Ile Lys Asp Ala Asp 
                245                 250                 255     


Glu Glu Lys Ala Ser Leu Gln Lys Ser Ile Ser Ile Thr Ser Ala Leu 
            260                 265                 270         


Leu Thr Glu Lys Asp Ala Glu Leu Glu Lys Leu Arg Asn Glu Val Thr 
        275                 280                 285             


Val Leu Arg Gly Glu Asn Ala Ser Ala Lys Ser Leu His Ser Val Val 
    290                 295                 300                 


Gln Thr Leu Glu Ser Asp Lys Val Lys Leu Glu Leu Lys Val Lys Asn 
305                 310                 315                 320 


Leu Glu Leu Gln Leu Lys Glu Asn Lys Arg Gln Leu Ser Ser Ser Ser 
                325                 330                 335     


Gly Asn Thr Asp Thr Gln Ala Asp Glu Asp Glu Arg Ala Gln Glu Ser 
            340                 345                 350         


Gln Val Met Ile Asp Phe Leu Asn Ser Val Ile Val Asp Leu Gln Arg 
        355                 360                 365             


Lys Asn Gln Asp Leu Lys Met Lys Val Glu Met Met Ser Glu Ala Ala 
    370                 375                 380                 


Leu Asn Gly Asn Gly Asp Asp Leu Asn Asn Tyr Asp Ser Asp Asp Gln 
385                 390                 395                 400 


Glu Lys Gln Ser Lys Lys Lys Pro Arg Leu Phe Cys Asp Ile Cys Asp 
                405                 410                 415     


Cys Phe Asp Leu His Asp Thr Glu Asp Cys Pro Thr Gln Ala Gln Met 
            420                 425                 430         


Ser Glu Asp Pro Pro His Ser Thr His His Gly Ser Arg Gly Glu Glu 
        435                 440                 445             


Arg Pro Tyr Cys Glu Ile Cys Glu Met Phe Gly His Trp Ala Thr Asn 
    450                 455                 460                 


Cys Asn Asp Asp Glu Thr Phe 
465                 470     


<210> 6782
<211> 533
<212> PRT
<213> Homo sapiens

<400> 6782
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Thr 
    530             


<210> 6783
<211> 556
<212> PRT
<213> Homo sapiens

<400> 6783
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Gly Thr Lys Lys Lys Lys Gly Leu Asp Ser Met Thr 
    530                 535                 540                 


Ser Thr Val Ala Ala Gly Trp Leu Asp Arg Arg Val 
545                 550                 555     


<210> 6784
<211> 102
<212> PRT
<213> Homo sapiens

<400> 6784
Met Leu Ser Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln 
1               5                   10                  15      


Leu Glu Asp Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu 
            20                  25                  30          


Arg His Leu Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn 
        35                  40                  45              


Glu Leu Lys Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr 
    50                  55                  60                  


Thr Ala Tyr Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys 
65                  70                  75                  80  


Ala Thr Ala Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe 
                85                  90                  95      


Gly Asp Met Arg Arg Lys 
            100         


<210> 6785
<211> 204
<212> PRT
<213> Homo sapiens

<400> 6785
Met Glu Ala Glu Pro Lys Gly Leu Leu Glu Thr Glu Pro Leu Gln Gly 
1               5                   10                  15      


Thr Asp Glu Asp Ala Val Ala Ser Ala Asp Phe Ser Ser Met Leu Ser 
            20                  25                  30          


Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln Leu Glu Asp 
        35                  40                  45              


Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu Arg His Leu 
    50                  55                  60                  


Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn Glu Leu Lys 
65                  70                  75                  80  


Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr Thr Ala Tyr 
                85                  90                  95      


Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys Ala Thr Ala 
            100                 105                 110         


Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe Gly Asp Met 
        115                 120                 125             


Ser Tyr Ser Ile Arg His Ser Ile Ser Met Pro Ala Met Arg Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys Ser Phe Glu Glu Arg Val Glu Thr Thr Val Thr Ser 
145                 150                 155                 160 


Leu Lys Thr Lys Val Gly Gly Thr Asn Pro Asn Gly Gly Ser Phe Glu 
                165                 170                 175     


Glu Val Leu Ser Ser Thr Ala His Ala Ser Ala Gln Ser Leu Ala Gly 
            180                 185                 190         


Gly Ser Arg Arg Thr Lys Glu Glu Glu Leu Gln Cys 
        195                 200                 


<210> 6786
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6786
Xaa Tyr Leu Val Ala Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu 
1               5                   10                  15      


Thr Val Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu 
            20                  25                  30          


Asn Ile Leu Arg Leu Gly Glu Gln Glu Ser Lys Gln Asn Gly Ile Gly 
        35                  40                  45              


Ile Asn Pro Tyr Cys Ala Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys 
    50                  55                  60                  


Ile Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala 
65                  70                  75                  80  


Phe Asp Leu Ile Glu His Tyr Phe Gly Val Glu Glu Asp Asp Pro Ser 
                85                  90                  95      


Ile Val Pro Gln Val Asp Glu Asn Gln Gln Gln Phe Ile Phe Gln Gln 
            100                 105                 110         


Gln Glu Ala Pro Met Asp Gly Phe Gln Leu 
        115                 120         


<210> 6787
<211> 378
<212> PRT
<213> Homo sapiens

<400> 6787
Met Glu Val Lys Pro Pro Pro Gly Arg Pro Gln Pro Asp Ser Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Gly Glu Glu Gly His Asp Pro Lys Glu Pro Glu 
            20                  25                  30          


Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp 
        35                  40                  45              


Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys 
    50                  55                  60                  


Val Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe 
65                  70                  75                  80  


Val Thr Tyr Ser Cys Val Glu Glu Val Asp Ala Ala Met Cys Ala Arg 
                85                  90                  95      


Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser 
            100                 105                 110         


Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr Val Lys Lys Ile 
        115                 120                 125             


Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp 
    130                 135                 140                 


Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu Val Met Glu Asp 
145                 150                 155                 160 


Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp 
                165                 170                 175     


His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr His Thr Ile Asn 
            180                 185                 190         


Gly His Asn Cys Glu Val Lys Lys Ala Leu Ser Lys Gln Glu Met Gln 
        195                 200                 205             


Ser Ala Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Phe Met 
    210                 215                 220                 


Gly Arg Gly Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser 
                245                 250                 255     


Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly 
            260                 265                 270         


Asp Gly Gly Asn Tyr Gly Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly 
        275                 280                 285             


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
    290                 295                 300                 


Gly Gly Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly 
305                 310                 315                 320 


Gly Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser 
                325                 330                 335     


Gly Gln Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly 
            340                 345                 350         


Gly Arg Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Tyr Gly Ser Arg Arg Phe 
    370                 375             


<210> 6788
<211> 1020
<212> PRT
<213> Homo sapiens

<400> 6788
Met Arg Arg Phe Leu Arg Pro Gly His Asp Pro Val Arg Glu Arg Leu 
1               5                   10                  15      


Lys Arg Asp Leu Phe Gln Phe Asn Lys Thr Val Glu His Gly Phe Pro 
            20                  25                  30          


His Gln Pro Ser Ala Leu Gly Tyr Ser Pro Ser Leu Arg Ile Leu Ala 
        35                  40                  45              


Ile Gly Thr Arg Ser Gly Ala Ile Lys Leu Tyr Gly Ala Pro Gly Val 
    50                  55                  60                  


Glu Phe Met Gly Leu His Gln Glu Asn Asn Ala Val Thr Gln Ile His 
65                  70                  75                  80  


Leu Leu Pro Gly Gln Cys Gln Leu Val Thr Leu Leu Asp Asp Asn Ser 
                85                  90                  95      


Leu His Leu Trp Ser Leu Lys Val Lys Gly Gly Ala Ser Glu Leu Gln 
            100                 105                 110         


Glu Asp Glu Ser Phe Thr Leu Arg Gly Pro Pro Gly Ala Ala Pro Ser 
        115                 120                 125             


Ala Thr Gln Ile Thr Val Val Leu Pro His Ser Ser Cys Glu Leu Leu 
    130                 135                 140                 


Tyr Leu Gly Thr Glu Ser Gly Asn Val Phe Val Val Gln Leu Pro Ala 
145                 150                 155                 160 


Phe Arg Ala Leu Glu Asp Arg Thr Ile Ser Ser Asp Ala Val Leu Gln 
                165                 170                 175     


Arg Leu Pro Glu Glu Ala Arg His Arg Arg Val Phe Glu Met Val Glu 
            180                 185                 190         


Ala Leu Gln Glu His Pro Arg Asp Pro Asn Gln Ile Leu Ile Gly Tyr 
        195                 200                 205             


Ser Arg Gly Leu Val Val Ile Trp Asp Leu Gln Gly Ser Arg Val Leu 
    210                 215                 220                 


Tyr His Phe Leu Ser Ser Gln Gln Leu Glu Asn Ile Trp Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Arg Leu Leu Val Ser Cys His Ser Asp Gly Ser Tyr Cys Gln 
                245                 250                 255     


Trp Pro Val Ser Ser Glu Ala Gln Gln Pro Glu Pro Leu Arg Ser Leu 
            260                 265                 270         


Val Pro Tyr Gly Pro Phe Pro Cys Lys Ala Ile Thr Arg Ile Leu Trp 
        275                 280                 285             


Leu Thr Thr Arg Gln Gly Leu Pro Phe Thr Ile Phe Gln Gly Gly Met 
    290                 295                 300                 


Pro Arg Ala Ser Tyr Gly Asp Arg His Cys Ile Ser Val Ile His Asp 
305                 310                 315                 320 


Gly Gln Gln Thr Ala Phe Asp Phe Thr Ser Arg Val Ile Gly Phe Thr 
                325                 330                 335     


Val Leu Thr Glu Ala Asp Pro Ala Ala Thr Phe Asp Asp Pro Tyr Ala 
            340                 345                 350         


Leu Val Val Leu Ala Glu Glu Glu Leu Val Val Ile Asp Leu Gln Thr 
        355                 360                 365             


Ala Gly Trp Pro Pro Val Gln Leu Pro Tyr Leu Ala Ser Leu His Cys 
    370                 375                 380                 


Ser Ala Ile Thr Cys Ser His His Val Ser Asn Ile Pro Leu Lys Leu 
385                 390                 395                 400 


Trp Glu Arg Ile Ile Ala Ala Gly Ser Arg Gln Asn Ala His Phe Ser 
                405                 410                 415     


Thr Met Glu Trp Pro Ile Asp Gly Gly Thr Ser Leu Thr Pro Ala Pro 
            420                 425                 430         


Pro Gln Arg Asp Leu Leu Leu Thr Gly His Glu Asp Gly Thr Val Arg 
        435                 440                 445             


Phe Trp Asp Ala Ser Gly Val Cys Leu Arg Leu Leu Tyr Lys Leu Ser 
    450                 455                 460                 


Thr Val Arg Val Phe Leu Thr Asp Thr Asp Pro Asn Glu Asn Phe Ser 
465                 470                 475                 480 


Ala Gln Gly Glu Asp Glu Trp Pro Pro Leu Arg Lys Val Gly Ser Phe 
                485                 490                 495     


Asp Pro Tyr Ser Asp Asp Pro Arg Leu Gly Ile Gln Lys Ile Phe Leu 
            500                 505                 510         


Cys Lys Tyr Ser Gly Tyr Leu Ala Val Ala Gly Thr Ala Gly Gln Val 
        515                 520                 525             


Leu Val Leu Glu Leu Asn Asp Glu Ala Ala Glu Gln Ala Val Glu Gln 
    530                 535                 540                 


Val Glu Ala Asp Leu Leu Gln Asp Gln Glu Gly Tyr Arg Trp Lys Gly 
545                 550                 555                 560 


His Glu Arg Leu Ala Ala Arg Ser Gly Pro Val Arg Phe Glu Pro Gly 
                565                 570                 575     


Phe Gln Pro Phe Val Leu Val Gln Cys Gln Pro Pro Ala Val Val Thr 
            580                 585                 590         


Ser Leu Ala Leu His Ser Glu Trp Arg Leu Val Ala Phe Gly Thr Ser 
        595                 600                 605             


His Gly Phe Gly Leu Phe Asp His Gln Gln Arg Arg Gln Val Phe Val 
    610                 615                 620                 


Lys Cys Thr Leu His Pro Ser Asp Gln Leu Ala Leu Glu Gly Pro Leu 
625                 630                 635                 640 


Ser Arg Val Lys Ser Leu Lys Lys Ser Leu Arg Gln Ser Phe Arg Arg 
                645                 650                 655     


Met Arg Arg Ser Arg Val Ser Ser Arg Lys Arg His Pro Ala Gly Pro 
            660                 665                 670         


Pro Gly Glu Ala Gln Glu Gly Ser Ala Lys Ala Glu Arg Pro Gly Leu 
        675                 680                 685             


Gln Asn Met Glu Leu Ala Pro Val Gln Arg Lys Ile Glu Ala Arg Ser 
    690                 695                 700                 


Ala Glu Asp Ser Phe Thr Gly Phe Val Arg Thr Leu Tyr Phe Ala Asp 
705                 710                 715                 720 


Thr Tyr Leu Lys Asp Ser Ser Arg His Cys Pro Ser Leu Trp Ala Gly 
                725                 730                 735     


Thr Asn Gly Gly Thr Ile Tyr Ala Phe Ser Leu Arg Val Pro Pro Ala 
            740                 745                 750         


Glu Arg Arg Met Asp Glu Pro Val Arg Ala Glu Gln Ala Lys Glu Ile 
        755                 760                 765             


Gln Leu Met His Arg Ala Pro Val Val Gly Ile Leu Val Leu Asp Gly 
    770                 775                 780                 


His Ser Val Pro Leu Pro Glu Pro Leu Glu Val Ala His Asp Leu Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Met Gln Gly Ser His Gln Leu Leu Val Val Ser Glu 
                805                 810                 815     


Glu Gln Phe Lys Val Phe Thr Leu Pro Lys Val Ser Ala Lys Leu Lys 
            820                 825                 830         


Leu Lys Leu Thr Ala Leu Glu Gly Ser Arg Val Arg Arg Val Ser Val 
        835                 840                 845             


Ala His Phe Gly Ser Arg Arg Ala Glu Asp Tyr Gly Glu His His Leu 
    850                 855                 860                 


Ala Val Leu Thr Asn Leu Gly Asp Ile Gln Val Val Ser Leu Pro Leu 
865                 870                 875                 880 


Leu Lys Pro Gln Val Arg Tyr Ser Cys Ile Arg Arg Glu Asp Val Ser 
                885                 890                 895     


Gly Ile Ala Ser Cys Val Phe Thr Lys Tyr Gly Gln Gly Phe Tyr Leu 
            900                 905                 910         


Ile Ser Pro Ser Glu Phe Glu Arg Phe Ser Leu Ser Thr Lys Trp Leu 
        915                 920                 925             


Val Glu Pro Arg Cys Leu Val Asp Ser Ala Glu Thr Lys Asn His Arg 
    930                 935                 940                 


Pro Gly Asn Gly Ala Gly Pro Lys Lys Ala Pro Ser Arg Ala Arg Asn 
945                 950                 955                 960 


Ser Gly Thr Gln Ser Asp Gly Glu Glu Lys Gln Pro Gly Leu Val Met 
                965                 970                 975     


Glu Arg Ala Leu Leu Ser Asp Glu Arg Val Leu Lys Glu Ile Gln Ser 
            980                 985                 990         


Thr Leu Glu Gly Asp Arg Gly Ser  Gly Asn Trp Arg Ser  His Arg Ala 
        995                 1000                 1005             


Ala Val  Gly Cys Ser Leu Ser  Asn Gly Gly Ala Glu  
    1010                 1015                 1020 


<210> 6789
<211> 485
<212> PRT
<213> Homo sapiens

<400> 6789
Met Ala Ala Glu Leu Tyr Ala Pro Ala Ser Ala Ala Ala Ala Asp Leu 
1               5                   10                  15      


Ala Asn Ser Asn Ala Gly Ala Ala Val Gly Arg Lys Ala Gly Pro Arg 
            20                  25                  30          


Ser Pro Pro Ser Ala Pro Ala Pro Ala Pro Pro Pro Pro Ala Pro Ala 
        35                  40                  45              


Pro Pro Thr Leu Gly Asn Asn His Gln Glu Ser Pro Gly Trp Arg Cys 
    50                  55                  60                  


Cys Arg Pro Thr Leu Arg Glu Arg Asn Ala Leu Met Phe Asn Asn Glu 
65                  70                  75                  80  


Leu Met Ala Asp Val His Phe Val Val Gly Pro Pro Gly Ala Thr Arg 
                85                  90                  95      


Thr Val Pro Ala His Lys Tyr Val Leu Ala Val Gly Ser Ser Val Phe 
            100                 105                 110         


Tyr Ala Met Phe Tyr Gly Asp Leu Ala Glu Val Lys Ser Glu Ile His 
        115                 120                 125             


Ile Pro Asp Val Glu Pro Ala Ala Phe Leu Ile Leu Leu Lys Tyr Met 
    130                 135                 140                 


Tyr Ser Asp Glu Ile Asp Leu Glu Ala Asp Thr Val Leu Ala Thr Leu 
145                 150                 155                 160 


Tyr Ala Ala Lys Lys Tyr Ile Val Pro Ala Leu Ala Lys Ala Cys Val 
                165                 170                 175     


Asn Phe Leu Glu Thr Ser Leu Glu Ala Lys Asn Ala Cys Val Leu Leu 
            180                 185                 190         


Ser Gln Ser Arg Leu Phe Glu Glu Pro Glu Leu Thr Gln Arg Cys Trp 
        195                 200                 205             


Glu Val Ile Asp Ala Gln Ala Glu Met Ala Leu Arg Ser Glu Gly Phe 
    210                 215                 220                 


Cys Glu Ile Asp Arg Gln Thr Leu Glu Ile Ile Val Thr Arg Glu Ala 
225                 230                 235                 240 


Leu Asn Thr Lys Glu Ala Val Val Phe Glu Ala Val Leu Asn Trp Ala 
                245                 250                 255     


Glu Ala Glu Cys Lys Arg Gln Gly Leu Pro Ile Thr Pro Arg Asn Lys 
            260                 265                 270         


Arg His Val Leu Gly Arg Ala Leu Tyr Leu Val Arg Ile Pro Thr Met 
        275                 280                 285             


Thr Leu Glu Glu Phe Ala Asn Gly Ala Ala Gln Ser Asp Ile Leu Thr 
    290                 295                 300                 


Leu Glu Glu Thr His Ser Ile Phe Leu Trp Tyr Thr Ala Thr Asn Lys 
305                 310                 315                 320 


Pro Arg Leu Asp Phe Pro Leu Thr Lys Arg Lys Gly Leu Ala Pro Gln 
                325                 330                 335     


Arg Cys His Arg Phe Gln Ser Ser Ala Tyr Arg Ser Asn Gln Trp Arg 
            340                 345                 350         


Tyr Arg Gly Arg Cys Asp Ser Ile Gln Phe Ala Val Asp Arg Arg Val 
        355                 360                 365             


Phe Ile Ala Gly Leu Gly Leu Tyr Gly Ser Ser Ser Gly Lys Ala Glu 
    370                 375                 380                 


Tyr Ser Val Lys Ile Glu Leu Lys Arg Leu Gly Val Val Leu Ala Gln 
385                 390                 395                 400 


Asn Leu Thr Lys Phe Met Ser Asp Gly Ser Ser Asn Thr Phe Pro Val 
                405                 410                 415     


Trp Phe Glu His Pro Val Gln Val Glu Gln Asp Thr Phe Tyr Thr Ala 
            420                 425                 430         


Ser Ala Val Leu Asp Gly Ser Glu Leu Ser Tyr Phe Gly Gln Glu Gly 
        435                 440                 445             


Met Thr Glu Val Gln Cys Gly Lys Val Ala Phe Gln Phe Gln Cys Ser 
    450                 455                 460                 


Ser Asp Ser Thr Asn Gly Thr Gly Val Gln Gly Gly Gln Ile Pro Glu 
465                 470                 475                 480 


Leu Ile Phe Tyr Ala 
                485 


<210> 6790
<211> 960
<212> PRT
<213> Homo sapiens

<400> 6790
Met Ser Arg Leu Ile Val Lys Asn Leu Pro Asn Gly Met Lys Glu Glu 
1               5                   10                  15      


Arg Phe Arg Gln Leu Phe Ala Ala Phe Gly Thr Leu Thr Asp Cys Ser 
            20                  25                  30          


Leu Lys Phe Thr Lys Asp Gly Lys Phe Arg Lys Phe Gly Phe Ile Gly 
        35                  40                  45              


Phe Lys Ser Glu Glu Glu Ala Gln Lys Ala Gln Lys His Phe Asn Lys 
    50                  55                  60                  


Ser Phe Ile Asp Thr Ser Arg Ile Thr Val Glu Phe Cys Lys Ser Phe 
65                  70                  75                  80  


Gly Asp Pro Ala Lys Pro Arg Ala Trp Ser Lys His Ala Gln Lys Pro 
                85                  90                  95      


Ser Gln Pro Lys Gln Pro Pro Lys Asp Ser Thr Thr Pro Glu Ile Lys 
            100                 105                 110         


Lys Asp Glu Lys Lys Lys Lys Val Ala Gly Gln Leu Glu Lys Leu Lys 
        115                 120                 125             


Glu Asp Thr Glu Phe Gln Glu Phe Leu Ser Val His Gln Arg Arg Ala 
    130                 135                 140                 


Gln Ala Ala Thr Trp Ala Asn Asp Gly Leu Asp Ala Glu Pro Ser Lys 
145                 150                 155                 160 


Gly Lys Ser Lys Pro Ala Ser Asp Tyr Leu Asn Phe Asp Ser Asp Ser 
                165                 170                 175     


Gly Gln Glu Ser Glu Glu Glu Gly Ala Gly Glu Asp Leu Glu Glu Glu 
            180                 185                 190         


Ala Ser Leu Glu Pro Lys Ala Ala Val Gln Lys Glu Leu Ser Asp Met 
        195                 200                 205             


Asp Tyr Leu Lys Ser Lys Met Val Lys Ala Gly Ser Ser Ser Ser Ser 
    210                 215                 220                 


Glu Glu Glu Glu Ser Glu Asp Glu Ala Val His Cys Asp Glu Gly Ser 
225                 230                 235                 240 


Glu Ala Glu Glu Glu Asp Ser Ser Ala Thr Pro Val Leu Gln Glu Arg 
                245                 250                 255     


Asp Ser Lys Gly Ala Gly Gln Glu Gln Gly Met Pro Ala Gly Lys Lys 
            260                 265                 270         


Arg Pro Pro Glu Ala Arg Ala Glu Thr Glu Lys Pro Ala Asn Gln Lys 
        275                 280                 285             


Glu Pro Thr Thr Cys His Thr Val Lys Leu Arg Gly Ala Pro Phe Asn 
    290                 295                 300                 


Val Thr Glu Lys Asn Val Met Glu Phe Leu Ala Pro Leu Lys Pro Val 
305                 310                 315                 320 


Ala Ile Arg Ile Val Arg Asn Ala His Gly Asn Lys Thr Gly Tyr Ile 
                325                 330                 335     


Phe Val Asp Phe Ser Asn Glu Glu Glu Val Lys Gln Ala Leu Lys Cys 
            340                 345                 350         


Asn Arg Glu Tyr Met Gly Gly Arg Tyr Ile Glu Val Phe Arg Glu Lys 
        355                 360                 365             


Asn Val Pro Thr Thr Lys Gly Ala Pro Lys Asn Thr Thr Lys Ser Trp 
    370                 375                 380                 


Gln Gly Arg Ile Leu Gly Glu Asn Glu Glu Glu Glu Asp Leu Ala Glu 
385                 390                 395                 400 


Ser Gly Arg Leu Phe Val Arg Asn Leu Pro Tyr Thr Ser Thr Glu Glu 
                405                 410                 415     


Asp Leu Glu Lys Leu Phe Ser Lys Tyr Gly Pro Leu Ser Glu Leu His 
            420                 425                 430         


Tyr Pro Ile Asp Ser Leu Thr Lys Lys Pro Lys Gly Phe Ala Phe Ile 
        435                 440                 445             


Thr Phe Met Phe Pro Glu His Ala Val Lys Ala Tyr Ser Glu Val Asp 
    450                 455                 460                 


Gly Gln Val Phe Gln Gly Arg Met Leu His Val Leu Pro Ser Thr Ile 
465                 470                 475                 480 


Lys Lys Glu Ala Ser Glu Asp Ala Ser Ala Leu Gly Ser Ser Ser Tyr 
                485                 490                 495     


Lys Lys Lys Lys Glu Ala Gln Asp Lys Ala Asn Ser Ala Ser Ser His 
            500                 505                 510         


Asn Trp Asn Thr Leu Phe Met Gly Pro Asn Ala Val Ala Asp Ala Ile 
        515                 520                 525             


Ala Gln Lys Tyr Asn Ala Thr Lys Ser Gln Val Phe Asp His Glu Thr 
    530                 535                 540                 


Lys Gly Ser Val Ala Val Arg Val Ala Leu Gly Glu Thr Gln Leu Val 
545                 550                 555                 560 


Gln Glu Val Arg Arg Phe Leu Ile Asp Asn Gly Val Ser Leu Asp Ser 
                565                 570                 575     


Phe Ser Gln Ala Ala Ala Glu Arg Ser Lys Thr Val Ile Leu Val Lys 
            580                 585                 590         


Asn Leu Pro Ala Gly Thr Leu Ala Ala Gln Leu Gln Glu Thr Phe Gly 
        595                 600                 605             


His Phe Gly Ser Leu Gly Arg Val Leu Leu Pro Glu Gly Gly Ile Thr 
    610                 615                 620                 


Ala Ile Val Glu Phe Leu Glu Pro Leu Glu Ala Arg Lys Ala Phe Arg 
625                 630                 635                 640 


His Leu Ala Tyr Ser Lys Phe His His Val Pro Leu Tyr Leu Glu Trp 
                645                 650                 655     


Ala Pro Val Gly Val Phe Ser Ser Thr Ala Pro Gln Lys Lys Lys Leu 
            660                 665                 670         


Gln Asp Thr Pro Ser Glu Pro Met Glu Lys Asp Pro Ala Glu Pro Glu 
        675                 680                 685             


Thr Val Pro Asp Gly Glu Thr Pro Glu Asp Glu Asn Pro Thr Glu Glu 
    690                 695                 700                 


Gly Ala Asp Asn Ser Ser Ala Lys Met Glu Glu Glu Glu Glu Glu Glu 
705                 710                 715                 720 


Glu Glu Glu Glu Glu Ser Leu Pro Gly Cys Thr Leu Phe Ile Lys Asn 
                725                 730                 735     


Leu Asn Phe Asp Thr Thr Glu Glu Lys Leu Lys Glu Val Phe Ser Lys 
            740                 745                 750         


Val Gly Thr Val Lys Ser Cys Ser Ile Ser Lys Lys Lys Asn Lys Ala 
        755                 760                 765             


Gly Val Leu Leu Ser Met Gly Phe Gly Phe Val Glu Tyr Arg Lys Pro 
    770                 775                 780                 


Glu Gln Ala Gln Lys Ala Leu Lys Gln Leu Gln Gly His Val Val Asp 
785                 790                 795                 800 


Gly His Lys Leu Glu Val Arg Ile Ser Glu Arg Ala Thr Lys Pro Ala 
                805                 810                 815     


Val Thr Leu Ala Arg Lys Lys Gln Val Pro Arg Lys Gln Thr Thr Ser 
            820                 825                 830         


Lys Ile Leu Val Arg Asn Ile Pro Phe Gln Ala His Ser Arg Glu Ile 
        835                 840                 845             


Arg Glu Leu Phe Ser Thr Phe Gly Glu Leu Lys Thr Val Arg Leu Pro 
    850                 855                 860                 


Lys Lys Met Thr Gly Thr Gly Thr His Arg Gly Phe Gly Phe Val Asp 
865                 870                 875                 880 


Phe Leu Thr Lys Gln Asp Ala Lys Arg Ala Phe Asn Ala Leu Cys His 
                885                 890                 895     


Ser Thr His Leu Tyr Gly Arg Arg Leu Val Leu Glu Trp Ala Asp Ser 
            900                 905                 910         


Glu Val Thr Leu Gln Ala Leu Arg Arg Lys Thr Ala Ala His Phe His 
        915                 920                 925             


Glu Pro Pro Lys Lys Lys Arg Ser Val Val Leu Asp Glu Ile Leu Glu 
    930                 935                 940                 


Gln Leu Glu Gly Ser Asp Ser Asp Ser Glu Glu Gln Thr Leu Gln Leu 
945                 950                 955                 960 


<210> 6791
<211> 222
<212> PRT
<213> Homo sapiens

<400> 6791
Met Glu Arg Ile Glu Gly Ala Ser Val Gly Arg Cys Ala Ala Ser Pro 
1               5                   10                  15      


Tyr Leu Arg Pro Leu Thr Leu His Tyr Arg Gln Asn Gly Ala Gln Lys 
            20                  25                  30          


Ser Trp Asp Phe Met Lys Thr His Asp Ser Val Thr Val Leu Leu Phe 
        35                  40                  45              


Asn Ser Ser Arg Arg Ser Leu Val Leu Val Lys Gln Phe Arg Pro Ala 
    50                  55                  60                  


Val Tyr Ala Gly Glu Val Glu Arg Arg Phe Pro Gly Ser Leu Ala Ala 
65                  70                  75                  80  


Val Asp Gln Asp Gly Pro Arg Glu Leu Gln Pro Ala Leu Pro Gly Ser 
                85                  90                  95      


Ala Gly Val Thr Val Glu Leu Cys Ala Gly Leu Val Asp Gln Pro Gly 
            100                 105                 110         


Leu Ser Leu Glu Glu Val Ala Cys Lys Glu Ala Trp Glu Glu Cys Gly 
        115                 120                 125             


Tyr His Leu Ala Pro Ser Asp Leu Arg Arg Val Ala Thr Tyr Trp Ser 
    130                 135                 140                 


Gly Val Gly Leu Thr Gly Ser Arg Gln Thr Met Phe Tyr Thr Glu Val 
145                 150                 155                 160 


Thr Asp Ala Gln Arg Ser Gly Pro Gly Gly Gly Leu Val Glu Glu Gly 
                165                 170                 175     


Glu Leu Ile Glu Val Val His Leu Pro Leu Glu Gly Ala Gln Ala Phe 
            180                 185                 190         


Ala Asp Asp Pro Asp Ile Pro Lys Thr Leu Gly Val Ile Phe Gly Val 
        195                 200                 205             


Ser Trp Phe Leu Ser Gln Val Ala Pro Asn Leu Asp Leu Gln 
    210                 215                 220         


<210> 6792
<211> 291
<212> PRT
<213> Homo sapiens

<400> 6792
Met Asn Met Ile Trp Arg Asn Ser Ile Ser Cys Leu Arg Leu Gly Lys 
1               5                   10                  15      


Val Pro His Arg Tyr Gln Ser Gly Tyr His Pro Val Ala Pro Leu Gly 
            20                  25                  30          


Ser Arg Ile Leu Thr Asp Pro Ala Lys Val Phe Glu His Asn Met Trp 
        35                  40                  45              


Asp His Met Gln Trp Ser Lys Glu Glu Glu Ala Ala Ala Arg Lys Lys 
    50                  55                  60                  


Val Lys Glu Asn Ser Ala Val Arg Val Leu Leu Glu Glu Gln Val Lys 
65                  70                  75                  80  


Tyr Glu Arg Glu Ala Ser Lys Tyr Trp Asp Thr Phe Tyr Lys Ile His 
                85                  90                  95      


Lys Asn Lys Phe Phe Lys Asp Arg Asn Trp Leu Leu Arg Glu Phe Pro 
            100                 105                 110         


Glu Ile Leu Pro Val Asp Gln Lys Pro Glu Glu Lys Ala Arg Glu Ser 
        115                 120                 125             


Ser Trp Asp His Val Lys Thr Ser Ala Thr Asn Arg Phe Ser Arg Met 
    130                 135                 140                 


His Cys Pro Thr Val Pro Asp Glu Lys Asn His Tyr Glu Lys Ser Ser 
145                 150                 155                 160 


Gly Ser Ser Glu Gly Gln Ser Lys Thr Glu Ser Asp Phe Ser Asn Leu 
                165                 170                 175     


Asp Ser Glu Lys His Lys Lys Gly Pro Met Glu Thr Gly Leu Phe Pro 
            180                 185                 190         


Gly Ser Asn Ala Thr Phe Arg Ile Leu Glu Val Gly Cys Gly Ala Gly 
        195                 200                 205             


Asn Ser Val Phe Pro Ile Leu Asn Thr Leu Glu Asn Ser Pro Glu Ser 
    210                 215                 220                 


Phe Leu Tyr Cys Cys Asp Phe Ala Ser Gly Ala Val Glu Leu Val Lys 
225                 230                 235                 240 


Ser His Ser Ser Tyr Arg Ala Thr Gln Cys Phe Ala Phe Val His Asp 
                245                 250                 255     


Val Cys Asp Asp Gly Leu Pro Tyr Pro Phe Pro Asp Gly Ile Leu Asp 
            260                 265                 270         


Val Ile Leu Leu Val Phe Val Leu Ser Ser Ile His Pro Asp Arg Thr 
        275                 280                 285             


Leu Phe Ile 
    290     


<210> 6793
<211> 209
<212> PRT
<213> Homo sapiens

<400> 6793
Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val 
1               5                   10                  15      


Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg 
            20                  25                  30          


Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp 
        35                  40                  45              


Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val 
    50                  55                  60                  


Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe 
65                  70                  75                  80  


Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu 
                85                  90                  95      


Phe Glu Leu Thr Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu 
            100                 105                 110         


Ser Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro 
        115                 120                 125             


Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr 
    130                 135                 140                 


Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser 
145                 150                 155                 160 


Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile 
                165                 170                 175     


Asp Ile Ile Ala Glu Leu Arg Tyr Asp Leu Pro Ala Ser Tyr Lys Phe 
            180                 185                 190         


His Lys Lys Lys Ser Val Asp Ile Glu Val Asp Leu Ile Arg Phe Ser 
        195                 200                 205             


Phe 
    


<210> 6794
<211> 167
<212> PRT
<213> Homo sapiens

<400> 6794
Met Pro Ala Tyr His Ser Ser Leu Met Asp Pro Asp Thr Lys Leu Ile 
1               5                   10                  15      


Gly Asn Met Ala Leu Leu Pro Ile Arg Ser Gln Phe Lys Gly Pro Ala 
            20                  25                  30          


Pro Arg Glu Thr Lys Asp Thr Asp Ile Val Asp Glu Ala Ile Tyr Tyr 
        35                  40                  45              


Phe Lys Ala Asn Val Phe Phe Lys Asn Tyr Glu Ile Lys Asn Glu Ala 
    50                  55                  60                  


Asp Arg Thr Leu Ile Tyr Ile Thr Leu Tyr Ile Ser Glu Cys Leu Lys 
65                  70                  75                  80  


Lys Leu Gln Lys Cys Asn Ser Lys Ser Gln Gly Glu Lys Glu Met Tyr 
                85                  90                  95      


Thr Leu Gly Ile Thr Asn Phe Pro Ile Pro Gly Glu Pro Gly Phe Pro 
            100                 105                 110         


Leu Asn Ala Ile Tyr Ala Lys Pro Ala Asn Lys Gln Glu Asp Glu Val 
        115                 120                 125             


Met Arg Ala Tyr Leu Gln Gln Leu Arg Gln Glu Thr Gly Leu Arg Leu 
    130                 135                 140                 


Cys Glu Lys Val Ile Lys Gly Asp Leu Lys Phe Ser Ala Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Leu Asn Lys Asn Lys 
                165         


<210> 6795
<211> 1357
<212> PRT
<213> Homo sapiens

<400> 6795
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Ala Gly Asn Pro Leu Val Gln 
        35                  40                  45              


Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn Pro Ala Pro Gly Leu 
    50                  55                  60                  


Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro Val Gln Val Met Gln 
65                  70                  75                  80  


Asn Ala Asn His Val Thr Ser Ser Pro Val Ala Ser Gln Pro Ile Phe 
                85                  90                  95      


Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val Arg Pro Val Gln Asn 
            100                 105                 110         


Ala Met Asn Gln Val Gly Ile Val Leu Asn Val Gln Gln Gly Gln Thr 
        115                 120                 125             


Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly Thr Gln Phe Val Lys 
    130                 135                 140                 


Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln Met Thr Pro Val Arg 
145                 150                 155                 160 


Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr Asn Thr Phe Thr Thr 
                165                 170                 175     


Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr Val Pro Gln Ser Gln 
            180                 185                 190         


Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser Thr Thr Pro Thr Ala 
        195                 200                 205             


Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val Gln Ser Pro Gly Gln 
    210                 215                 220                 


Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro Ser Phe Pro Ser Pro 
225                 230                 235                 240 


Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val Lys Arg Pro Gly Val 
                245                 250                 255     


Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu Val Asn Thr Leu Asn 
            260                 265                 270         


Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro Val Val Val Ser Asn 
        275                 280                 285             


Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser Gly Pro Glu Ser Ser 
    290                 295                 300                 


Met Lys Val Thr Ser Ser Ile Pro Val Phe Asp Leu Gln Asp Gly Gly 
305                 310                 315                 320 


Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln Phe Arg Val Thr Glu Ala 
                325                 330                 335     


Leu Arg Gly His Met Cys Tyr Cys Cys Pro Glu Met Val Glu Tyr Gln 
            340                 345                 350         


Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro Ser Val Pro Ser Ala Ala 
        355                 360                 365             


Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro Val Ala Ser Thr Pro Ser 
    370                 375                 380                 


Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro Thr Lys Val Pro Glu Pro 
385                 390                 395                 400 


Asn Glu Asn Val Gly Asp Ala Val Gln Thr Lys Leu Ile Met Leu Val 
                405                 410                 415     


Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly Lys Val Ala Gln Leu Thr 
            420                 425                 430         


Asn Phe Pro Lys Val Ala Thr Ser Phe Arg Cys Pro His Cys Thr Lys 
        435                 440                 445             


Arg Leu Lys Asn Asn Ile Arg Phe Met Asn His Met Lys His His Val 
    450                 455                 460                 


Glu Leu Asp Gln Gln Asn Gly Glu Val Asp Gly His Thr Ile Cys Gln 
465                 470                 475                 480 


His Cys Tyr Arg Gln Phe Ser Thr Pro Phe Gln Leu Gln Cys His Leu 
                485                 490                 495     


Glu Asn Val His Ser Pro Tyr Glu Ser Thr Thr Lys Cys Lys Ile Cys 
            500                 505                 510         


Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe Leu Gln His Met Lys Asp 
        515                 520                 525             


Thr His Lys Pro Gly Glu Met Pro Tyr Val Cys Gln Val Cys Gln Tyr 
    530                 535                 540                 


Arg Ser Ser Leu Tyr Ser Glu Val Asp Val His Phe Arg Met Ile His 
545                 550                 555                 560 


Glu Asp Thr Arg His Leu Leu Cys Pro Tyr Cys Leu Lys Val Phe Lys 
                565                 570                 575     


Asn Gly Asn Ala Phe Gln Gln His Tyr Met Arg His Gln Lys Arg Asn 
            580                 585                 590         


Val Tyr His Cys Asn Lys Cys Arg Leu Gln Phe Leu Phe Ala Lys Asp 
        595                 600                 605             


Lys Ile Glu His Lys Leu Gln His His Lys Thr Phe Arg Lys Pro Lys 
    610                 615                 620                 


Gln Leu Glu Gly Leu Lys Pro Gly Thr Lys Val Thr Ile Arg Ala Ser 
625                 630                 635                 640 


Arg Gly Gln Pro Arg Thr Val Pro Val Ser Ser Asn Asp Thr Pro Pro 
                645                 650                 655     


Ser Ala Leu Gln Glu Ala Ala Pro Leu Thr Ser Ser Met Asp Pro Leu 
            660                 665                 670         


Pro Val Phe Leu Tyr Pro Pro Val Gln Arg Ser Ile Gln Lys Arg Ala 
        675                 680                 685             


Val Arg Lys Met Ser Val Met Gly Arg Gln Thr Cys Leu Glu Cys Ser 
    690                 695                 700                 


Phe Glu Ile Pro Asp Phe Pro Asn His Phe Pro Thr Tyr Val His Cys 
705                 710                 715                 720 


Ser Leu Cys Arg Tyr Ser Thr Cys Cys Ser Arg Ala Tyr Ala Asn His 
                725                 730                 735     


Met Ile Asn Asn His Val Pro Arg Lys Ser Pro Lys Tyr Leu Ala Leu 
            740                 745                 750         


Phe Lys Asn Ser Val Ser Gly Ile Lys Leu Ala Cys Thr Ser Cys Thr 
        755                 760                 765             


Phe Val Thr Ser Val Gly Asp Ala Met Ala Lys His Leu Val Phe Asn 
    770                 775                 780                 


Pro Ser His Arg Ser Ser Ser Ile Leu Pro Arg Gly Leu Thr Trp Ile 
785                 790                 795                 800 


Ala His Ser Arg His Gly Gln Thr Arg Asp Arg Val His Asp Arg Asn 
                805                 810                 815     


Val Lys Asn Met Tyr Pro Pro Pro Ser Phe Pro Thr Asn Lys Ala Ala 
            820                 825                 830         


Thr Val Lys Ser Ala Gly Ala Thr Pro Ala Glu Pro Glu Glu Leu Leu 
        835                 840                 845             


Thr Pro Leu Ala Pro Ala Leu Pro Ser Pro Ala Ser Thr Ala Thr Pro 
    850                 855                 860                 


Pro Pro Thr Pro Thr His Pro Gln Ala Leu Ala Leu Pro Pro Leu Ala 
865                 870                 875                 880 


Thr Glu Gly Ala Glu Cys Leu Asn Val Asp Asp Gln Asp Glu Gly Ser 
                885                 890                 895     


Pro Val Thr Gln Glu Pro Glu Leu Ala Ser Gly Gly Gly Gly Ser Gly 
            900                 905                 910         


Gly Val Gly Lys Lys Glu Gln Leu Ser Val Lys Lys Leu Arg Val Val 
        915                 920                 925             


Leu Phe Ala Leu Cys Cys Asn Thr Glu Gln Ala Ala Glu His Phe Arg 
    930                 935                 940                 


Asn Pro Gln Arg Arg Ile Arg Arg Trp Leu Arg Arg Phe Gln Ala Ser 
945                 950                 955                 960 


Gln Gly Glu Asn Leu Glu Gly Lys Tyr Leu Ser Phe Glu Ala Glu Glu 
                965                 970                 975     


Lys Leu Ala Glu Trp Val Leu Thr Gln Arg Glu Gln Gln Leu Pro Val 
            980                 985                 990         


Asn Glu Glu Thr Leu Phe Gln Lys  Ala Thr Lys Ile Gly  Arg Ser Leu 
        995                 1000                 1005             


Glu Gly  Gly Phe Lys Ile Ser  Tyr Glu Trp Ala Val  Arg Phe Met 
    1010                 1015                 1020             


Leu Arg  His His Leu Thr Pro  His Ala Arg Arg Ala  Val Ala His 
    1025                 1030                 1035             


Thr Leu  Pro Lys Asp Val Ala  Glu Asn Ala Gly Leu  Phe Ile Asp 
    1040                 1045                 1050             


Phe Val  Gln Arg Gln Ile His  Asn Gln Asp Leu Pro  Leu Ser Met 
    1055                 1060                 1065             


Ile Val  Ala Ile Asp Glu Ile  Ser Leu Phe Leu Asp  Thr Glu Val 
    1070                 1075                 1080             


Leu Ser  Ser Asp Asp Arg Lys  Glu Asn Ala Leu Gln  Thr Val Gly 
    1085                 1090                 1095             


Thr Gly  Glu Pro Trp Cys Asp  Val Val Leu Ala Ile  Leu Ala Asp 
    1100                 1105                 1110             


Gly Thr  Val Leu Pro Thr Leu  Val Phe Tyr Arg Gly  Gln Met Asp 
    1115                 1120                 1125             


Gln Pro  Ala Asn Met Pro Asp  Ser Ile Leu Leu Glu  Ala Lys Glu 
    1130                 1135                 1140             


Ser Gly  Tyr Ser Asp Asp Glu  Ile Met Glu Leu Trp  Ser Thr Arg 
    1145                 1150                 1155             


Val Trp  Gln Lys His Thr Ala  Cys Gln Arg Ser Lys  Gly Met Leu 
    1160                 1165                 1170             


Val Met  Asp Cys His Arg Thr  His Leu Ser Glu Glu  Val Leu Ala 
    1175                 1180                 1185             


Met Leu  Ser Ala Ser Ser Thr  Leu Pro Ala Val Val  Pro Ala Gly 
    1190                 1195                 1200             


Cys Ser  Ser Lys Ile Gln Pro  Leu Asp Val Cys Ile  Lys Arg Thr 
    1205                 1210                 1215             


Val Lys  Asn Phe Leu His Lys  Lys Trp Lys Glu Gln  Ala Arg Glu 
    1220                 1225                 1230             


Met Ala  Asp Thr Ala Cys Asp  Ser Asp Val Leu Leu  Gln Leu Val 
    1235                 1240                 1245             


Leu Val  Trp Leu Gly Glu Val  Leu Gly Val Ile Gly  Asp Cys Pro 
    1250                 1255                 1260             


Glu Leu  Val Gln Arg Ser Phe  Leu Val Ala Ser Val  Leu Pro Gly 
    1265                 1270                 1275             


Pro Asp  Gly Asn Ile Asn Ser  Pro Thr Arg Asn Ala  Asp Met Gln 
    1280                 1285                 1290             


Glu Glu  Leu Ile Ala Ser Leu  Glu Glu Gln Leu Lys  Leu Ser Gly 
    1295                 1300                 1305             


Glu His  Ser Glu Ser Ser Thr  Pro Arg Pro Arg Ser  Ser Pro Glu 
    1310                 1315                 1320             


Glu Thr  Ile Glu Pro Glu Ser  Leu His Gln Leu Phe  Glu Gly Glu 
    1325                 1330                 1335             


Ser Glu  Thr Glu Ser Phe Tyr  Gly Phe Glu Glu Ala  Asp Leu Asp 
    1340                 1345                 1350             


Leu Met  Glu Ile 
    1355         


<210> 6796
<211> 95
<212> PRT
<213> Homo sapiens

<400> 6796
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Gly Tyr His Ser 
                85                  90                  95  


<210> 6797
<211> 235
<212> PRT
<213> Homo sapiens

<400> 6797
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Thr Gln Asp Trp Lys Pro Ala 
225                 230                 235 


<210> 6798
<211> 362
<212> PRT
<213> Homo sapiens

<400> 6798
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Phe Thr Glu Ile Ser His Arg Ile Leu Cys Ser Tyr 
225                 230                 235                 240 


Asn Thr Asn Ile Glu Glu Leu Phe Ala Glu Ile Asp Gln Cys Leu Ala 
                245                 250                 255     


Ile Asn Arg Ser Val Leu Gln Gln Leu Glu Glu Lys Cys Gly His Glu 
            260                 265                 270         


Ile Thr Glu Glu Glu Trp Glu Lys Ile Gln Val Gln Ala Leu Arg Arg 
        275                 280                 285             


Glu Thr His Glu Cys Ser Ile Cys Leu Ala Pro Leu Ser Ala Ala Gly 
    290                 295                 300                 


Gly Gln Arg Val Gly Ala Gly Arg Arg Ser Arg Glu Met Ala Leu Leu 
305                 310                 315                 320 


Ser Cys Ser His Val Phe His His Ala Cys Leu Leu Ala Leu Glu Glu 
                325                 330                 335     


Phe Ser Val Gly Asp Arg Pro Pro Phe His Ala Cys Pro Leu Cys Arg 
            340                 345                 350         


Ser Cys Tyr Gln Lys Lys Ile Leu Glu Cys 
        355                 360         


<210> 6799
<211> 425
<212> PRT
<213> Homo sapiens

<400> 6799
Met Asp Lys Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe 
1               5                   10                  15      


Arg Gln Ala Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln 
            20                  25                  30          


Lys Thr Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu 
        35                  40                  45              


Ser Leu Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu 
    50                  55                  60                  


Val Asn Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu 
65                  70                  75                  80  


Asp Ser Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp 
                85                  90                  95      


Lys Val Ile Ser Gly Ile Ala Arg Glu Lys Leu Pro Lys Val Arg Arg 
            100                 105                 110         


Gln Glu Val Ser Ser Pro Arg Lys Glu Thr Ser Ala Arg Ser Leu Gly 
        115                 120                 125             


Ser Pro Leu Leu His Glu Arg Gly Asn Ile Glu Lys Thr Phe Trp Asp 
    130                 135                 140                 


Leu Lys Glu Glu Phe His Lys Ile Cys Met Leu Ala Lys Ala Gln Lys 
145                 150                 155                 160 


Asp His Leu Ser Lys Leu Asn Ile Pro Asp Thr Ala Thr Glu Thr Gln 
                165                 170                 175     


Cys Ser Val Pro Ile Gln Cys Thr Asp Lys Thr Asp Lys Gln Glu Ala 
            180                 185                 190         


Leu Phe Lys Pro Gln Ala Lys Asp Asp Ile Asn Arg Gly Ala Pro Ser 
        195                 200                 205             


Ile Thr Ser Val Thr Pro Arg Gly Leu Cys Arg Asp Glu Glu Asp Thr 
    210                 215                 220                 


Ser Phe Glu Ser Leu Ser Lys Phe Asn Val Lys Phe Pro Pro Met Asp 
225                 230                 235                 240 


Asn Asp Ser Thr Phe Leu His Ser Thr Pro Glu Arg Pro Gly Ile Leu 
                245                 250                 255     


Ser Pro Ala Thr Ser Glu Ala Val Cys Gln Glu Lys Phe Asn Met Glu 
            260                 265                 270         


Phe Arg Asp Asn Pro Gly Asn Phe Val Lys Thr Glu Glu Thr Leu Phe 
        275                 280                 285             


Glu Ile Gln Gly Ile Asp Pro Ile Ala Ser Ala Ile Gln Asn Leu Lys 
    290                 295                 300                 


Thr Thr Asp Lys Thr Lys Pro Ser Asn Leu Val Asn Thr Cys Ile Arg 
305                 310                 315                 320 


Thr Thr Leu Asp Arg Ala Ala Cys Leu Pro Pro Gly Asp His Asn Ala 
                325                 330                 335     


Leu Tyr Val Asn Ser Phe Pro Leu Leu Asp Pro Ser Asp Ala Pro Phe 
            340                 345                 350         


Pro Ser Leu Asp Ser Pro Gly Lys Ala Ile Arg Gly Pro Gln Gln Pro 
        355                 360                 365             


Ile Trp Lys Pro Phe Pro Asn Gln Asp Ser Asp Ser Val Val Leu Ser 
    370                 375                 380                 


Gly Thr Asp Ser Glu Leu His Ile Pro Arg Val Cys Glu Phe Cys Gln 
385                 390                 395                 400 


Ala Val Phe Pro Pro Ser Ile Thr Ser Arg Gly Asp Phe Leu Arg His 
                405                 410                 415     


Leu Asn Ser His Phe Asn Gly Glu Thr 
            420                 425 


<210> 6800
<211> 212
<212> PRT
<213> Homo sapiens

<400> 6800
Met Ala Pro Trp Gly Lys Arg Leu Ala Gly Val Arg Gly Val Leu Leu 
1               5                   10                  15      


Asp Ile Ser Gly Val Leu Tyr Asp Ser Gly Ala Gly Gly Gly Thr Ala 
            20                  25                  30          


Ile Ala Gly Ser Val Glu Ala Val Ala Arg Leu Lys Arg Ser Arg Leu 
        35                  40                  45              


Lys Val Arg Phe Cys Thr Asn Glu Ser Gln Lys Ser Arg Ala Glu Leu 
    50                  55                  60                  


Val Gly Gln Leu Gln Arg Leu Gly Phe Asp Ile Ser Glu Gln Glu Val 
65                  70                  75                  80  


Thr Ala Pro Ala Pro Ala Ala Cys Gln Ile Leu Lys Glu Gln Gly Leu 
                85                  90                  95      


Arg Pro Tyr Leu Leu Ile His Asp Gly Val Arg Ser Glu Phe Asp Gln 
            100                 105                 110         


Ile Asp Thr Ser Asn Pro Asn Cys Val Val Ile Ala Asp Ala Gly Glu 
        115                 120                 125             


Ser Phe Ser Tyr Gln Asn Met Asn Asn Ala Phe Gln Val Leu Met Glu 
    130                 135                 140                 


Leu Glu Lys Pro Val Leu Ile Ser Leu Gly Lys Gly Arg Tyr Tyr Lys 
145                 150                 155                 160 


Glu Thr Ser Gly Leu Met Leu Asp Val Gly Pro Tyr Met Lys Ala Leu 
                165                 170                 175     


Glu Tyr Ala Cys Gly Ile Lys Ala Glu Val Val Gly Lys Pro Ser Pro 
            180                 185                 190         


Glu Phe Phe Lys Ser Ala Leu Gln Ala Ile Gly Val Glu Ala His Gln 
        195                 200                 205             


Leu Leu Ser Val 
    210         


<210> 6801
<211> 955
<212> PRT
<213> Homo sapiens

<400> 6801
Met Glu Val Gly Ser Glu Glu Glu Lys Trp Glu Lys Leu Asp Ala Glu 
1               5                   10                  15      


Phe Asp His Phe Val Val Asp Met Lys Pro Phe Val Leu Lys Leu Pro 
            20                  25                  30          


His Arg Thr Glu Arg Gln Arg Cys Ala Leu Trp Ile Arg Lys Leu Cys 
        35                  40                  45              


Glu Pro Ser Gly Thr Gly Ala Gly Ile Met Gly Arg Lys Asn Arg Asn 
    50                  55                  60                  


Leu Tyr Ala Lys Leu Leu Leu His Met Leu Lys Arg Gly Ala Leu Glu 
65                  70                  75                  80  


Gly Pro Phe Thr His Arg Pro Glu Pro Gly Thr Leu Lys Ile Leu Pro 
                85                  90                  95      


Ser Tyr Met Ser Ile Tyr Phe Asp Glu Pro Asn Pro Ala Arg Ala Lys 
            100                 105                 110         


Gly Ser Ser Pro Glu Gly Leu Pro Ala Trp Val Leu Gly Glu Leu Glu 
        115                 120                 125             


Thr Ser Glu His Lys Leu Asn Glu Ser Trp Lys Leu Ser Ser Gly Glu 
    130                 135                 140                 


Asp Asn Thr Leu Val Gln Ser Pro Thr Asp Val Tyr Ser Arg Glu Gln 
145                 150                 155                 160 


Tyr Thr Gly Lys Leu Arg Val Arg Ser His Ser Leu Ser Pro Thr His 
                165                 170                 175     


Arg Glu Asp Gly Gln Asn Ile Thr Pro Lys Ile Cys Glu Val Tyr Ser 
            180                 185                 190         


Lys Lys Ser Pro Val Ser Leu Asp Asp Ser Asp Ile Glu Ala Arg Leu 
        195                 200                 205             


Asn Ser Trp Asn Leu Gly Ile Glu Asn Pro Arg Tyr Leu Arg Gln Lys 
    210                 215                 220                 


Pro Ile Pro Val Ser Leu Met Thr Pro Lys Phe Ser Leu Arg Lys Ser 
225                 230                 235                 240 


Ser Ser Phe His Asp Asp His Phe Leu Ser Arg Ile Arg Glu Lys Glu 
                245                 250                 255     


Leu Asp Met Lys Thr Lys Met Met Glu Ala Lys Phe His Glu Glu Lys 
            260                 265                 270         


Leu Lys Leu Gln Gln Lys His Asp Ala Asp Val Gln Lys Ile Leu Glu 
        275                 280                 285             


Arg Lys Asn Asn Glu Ile Glu Glu Leu Lys Thr Leu Tyr Arg Ser Lys 
    290                 295                 300                 


Gln His Glu Thr Glu Glu Thr Ile Arg Lys Leu Glu Lys Lys Val Gln 
305                 310                 315                 320 


Thr Leu Ile Arg Asp Cys Gln Val Ile Arg Glu Thr Lys Glu Asp Gln 
                325                 330                 335     


Ile Ala Glu Leu Lys Lys Ile Cys Glu Gln Ser Thr Glu Ser Leu Asn 
            340                 345                 350         


Asn Asp Trp Glu Lys Lys Leu His Asn Ala Val Ala Glu Met Glu Gln 
        355                 360                 365             


Glu Lys Phe Asp Leu Gln Lys Gln His Thr Glu Asn Ile Gln Glu Leu 
    370                 375                 380                 


Leu Glu Asp Thr Asn Val Arg Leu Asn Lys Met Glu Ser Glu Tyr Met 
385                 390                 395                 400 


Ala Gln Thr Gln Ser Thr Asn His Met Ile Lys Glu Leu Glu Ala Arg 
                405                 410                 415     


Val Gln Gln Leu Thr Gly Glu Ala Glu Asn Ser Asn Leu Gln Arg Gln 
            420                 425                 430         


Lys Leu Ile Gln Glu Lys Ala Glu Leu Glu Arg Cys Tyr Gln Ile Thr 
        435                 440                 445             


Cys Ser Glu Leu Gln Glu Val Lys Ala Arg Arg Asn Thr Leu His Lys 
    450                 455                 460                 


Glu Lys Asp His Leu Val Asn Asp Tyr Glu Gln Asn Met Lys Leu Leu 
465                 470                 475                 480 


Gln Thr Lys Tyr Asp Ala Asp Ile Asn Leu Leu Lys Gln Glu His Ala 
                485                 490                 495     


Leu Ser Ala Ser Lys Ala Ser Ser Met Ile Glu Glu Leu Glu Gln Asn 
            500                 505                 510         


Val Cys Gln Leu Lys Gln Gln Leu Gln Glu Ser Glu Leu Gln Arg Lys 
        515                 520                 525             


Gln Gln Leu Arg Asp Gln Glu Asn Lys Phe Gln Met Glu Lys Ser His 
    530                 535                 540                 


Leu Lys His Ile Tyr Glu Lys Lys Ala His Asp Leu Gln Ser Glu Leu 
545                 550                 555                 560 


Asp Lys Gly Lys Glu Asp Thr Gln Lys Lys Ile His Lys Phe Glu Glu 
                565                 570                 575     


Ala Leu Lys Glu Lys Glu Glu Gln Leu Thr Arg Val Thr Glu Val Gln 
            580                 585                 590         


Arg Leu Gln Ala Gln Gln Ala Asp Ala Ala Leu Glu Glu Phe Lys Arg 
        595                 600                 605             


Gln Val Glu Leu Asn Ser Glu Lys Val Tyr Ala Glu Met Lys Glu Gln 
    610                 615                 620                 


Met Glu Lys Val Glu Ala Asp Leu Thr Arg Ser Lys Ser Leu Arg Glu 
625                 630                 635                 640 


Lys Gln Ser Lys Glu Phe Leu Trp Gln Leu Glu Asp Ile Arg Gln Arg 
                645                 650                 655     


Tyr Glu Gln Gln Ile Val Glu Leu Lys Leu Glu His Glu Gln Glu Lys 
            660                 665                 670         


Thr His Leu Leu Gln Gln His Asn Ala Glu Lys Asp Ser Leu Val Arg 
        675                 680                 685             


Asp His Glu Arg Glu Ile Glu Asn Leu Glu Lys Gln Leu Arg Ala Ala 
    690                 695                 700                 


Asn Met Glu His Glu Asn Gln Ile Gln Glu Phe Lys Lys Arg Asp Ala 
705                 710                 715                 720 


Gln Val Ile Ala Asp Met Glu Ala Gln Val His Lys Leu Arg Glu Glu 
                725                 730                 735     


Leu Ile Asn Val Asn Ser Gln Arg Lys Gln Gln Leu Val Glu Leu Gly 
            740                 745                 750         


Leu Leu Arg Glu Glu Glu Lys Gln Arg Ala Thr Arg Glu His Glu Ile 
        755                 760                 765             


Val Val Asn Lys Leu Lys Ala Glu Ser Glu Lys Met Lys Ile Glu Leu 
    770                 775                 780                 


Lys Lys Thr His Ala Ala Glu Thr Glu Met Thr Leu Glu Lys Ala Asn 
785                 790                 795                 800 


Ser Lys Leu Lys Gln Ile Glu Lys Glu Tyr Thr Gln Lys Leu Ala Lys 
                805                 810                 815     


Ser Ser Gln Ile Ile Ala Glu Leu Gln Thr Thr Ile Ser Ser Leu Lys 
            820                 825                 830         


Glu Glu Asn Ser Gln Gln Gln Leu Ala Ala Glu Arg Arg Leu Gln Asp 
        835                 840                 845             


Val Arg Gln Lys Phe Glu Asp Glu Lys Lys Gln Leu Ile Arg Asp Asn 
    850                 855                 860                 


Asp Gln Ala Ile Lys Val Leu Gln Asp Glu Leu Glu Asn Arg Ser Asn 
865                 870                 875                 880 


Gln Val Arg Cys Ala Glu Lys Lys Leu Gln His Lys Glu Leu Glu Ser 
                885                 890                 895     


Gln Glu Gln Ile Thr Tyr Ile Arg Gln Glu Tyr Glu Thr Lys Leu Lys 
            900                 905                 910         


Gly Leu Met Pro Ala Ser Leu Arg Gln Glu Leu Glu Asp Thr Ile Ser 
        915                 920                 925             


Ser Leu Lys Ser Gln Val Asn Phe Leu Gln Lys Arg Ala Ser Ile Leu 
    930                 935                 940                 


Gln Glu Glu Leu Thr Thr Tyr Gln Gly Arg Arg 
945                 950                 955 


<210> 6802
<211> 422
<212> PRT
<213> Homo sapiens

<400> 6802
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu 
                165                 170                 175     


Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp 
            180                 185                 190         


Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp 
        195                 200                 205             


Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg 
    210                 215                 220                 


Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro 
225                 230                 235                 240 


Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp 
                245                 250                 255     


Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg 
            260                 265                 270         


Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Leu Asn Arg Val 
        275                 280                 285             


Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn Ile 
    290                 295                 300                 


Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys Asn 
305                 310                 315                 320 


His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala Glu 
                325                 330                 335     


Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile Asn 
            340                 345                 350         


Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys Asp 
        355                 360                 365             


Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile Glu 
    370                 375                 380                 


Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln Val 
385                 390                 395                 400 


Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Thr Gly Glu Thr 
                405                 410                 415     


Thr Ser Lys Arg Lys Lys 
            420         


<210> 6803
<211> 100
<212> PRT
<213> Homo sapiens

<400> 6803
Met Arg Lys Arg Leu Ser Ala Pro Glu Leu Arg Leu Ser Leu Thr Lys 
1               5                   10                  15      


Gly Pro Gly Asn Asp Gly Ala Ser Pro Thr Gln Ser Ala Pro Ser Ser 
            20                  25                  30          


Pro Asp Gly Ser Ser Asp Leu Glu Ile Asp Glu Leu Glu Thr Pro Ser 
        35                  40                  45              


Asp Ser Glu Gln Leu Asp Ser Gly His Glu Phe Glu Trp Glu Asp Glu 
    50                  55                  60                  


Leu Pro Arg Ala Glu Gly Leu Gly Thr Ser Glu Thr Ala Glu Arg Leu 
65                  70                  75                  80  


Gly Arg Gly Cys Met Trp Asp Val Thr Gly Glu Asp Gly His His Trp 
                85                  90                  95      


Arg Val Phe Arg 
            100 


<210> 6804
<211> 352
<212> PRT
<213> Homo sapiens

<400> 6804
Met Gly Lys Val Glu Asn Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu 
1               5                   10                  15      


Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ile Leu Gln Cys Leu 
            20                  25                  30          


Ser Asn Thr Arg Glu Leu Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met 
        35                  40                  45              


Arg Asp Leu His His Gly Ser Asn Ala His Thr Ala Leu Val Glu Glu 
    50                  55                  60                  


Phe Ala Lys Leu Ile Gln Thr Ile Trp Thr Ser Ser Pro Asn Asp Val 
65                  70                  75                  80  


Val Ser Pro Ser Glu Phe Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg 
                85                  90                  95      


Phe Val Gly Tyr Asn Gln Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu 
            100                 105                 110         


Leu Asp Gly Leu His Asn Glu Val Asn Arg Val Thr Leu Arg Pro Lys 
        115                 120                 125             


Ser Asn Pro Glu Asn Leu Asp His Leu Pro Asp Asp Glu Lys Gly Arg 
    130                 135                 140                 


Gln Met Trp Arg Lys Tyr Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp 
145                 150                 155                 160 


Leu Phe Val Gly Gln Leu Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly 
                165                 170                 175     


Tyr Cys Ser Thr Val Phe Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile 
            180                 185                 190         


Ala Lys Arg Gly Tyr Pro Glu Val Thr Leu Met Asp Cys Met Arg Leu 
        195                 200                 205             


Phe Thr Lys Glu Asp Val Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys 
    210                 215                 220                 


Arg Cys Arg Gly Arg Lys Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg 
225                 230                 235                 240 


Phe Pro Lys Ile Leu Val Leu His Leu Lys Arg Phe Ser Glu Ser Arg 
                245                 250                 255     


Ile Arg Thr Ser Lys Leu Thr Thr Phe Val Asn Phe Pro Leu Arg Asp 
            260                 265                 270         


Leu Asp Leu Arg Glu Phe Ala Ser Glu Asn Thr Asn His Ala Val Tyr 
        275                 280                 285             


Asn Leu Tyr Ala Val Ser Asn His Ser Gly Thr Thr Met Gly Gly His 
    290                 295                 300                 


Tyr Thr Ala Tyr Cys Arg Ser Pro Gly Thr Gly Glu Trp His Thr Phe 
305                 310                 315                 320 


Asn Asp Ser Ser Val Thr Pro Met Ser Ser Ser Gln Val Arg Thr Ser 
                325                 330                 335     


Asp Ala Tyr Leu Leu Phe Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
            340                 345                 350         


<210> 6805
<211> 498
<212> PRT
<213> Homo sapiens

<400> 6805
Met Val Ile Glu Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu 
1               5                   10                  15      


Lys Thr Cys Arg Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys 
            20                  25                  30          


Glu Asn Lys Thr Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu 
        35                  40                  45              


Gly Pro Asp Val Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser 
    50                  55                  60                  


Thr Thr Asp Thr Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys 
65                  70                  75                  80  


Gln Lys Gln Ile Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu 
                85                  90                  95      


Glu Lys Lys Ile Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Lys Leu 
            100                 105                 110         


Val Glu Val Ile Glu Glu Val Asn Lys Val Lys Gln Glu Lys Thr Val 
        115                 120                 125             


Leu Asn Ser Glu Val Leu Glu Gln Arg Lys Val Leu Glu Lys Cys Asn 
    130                 135                 140                 


Arg Val Ser Met Leu Ala Val Glu Glu Tyr Glu Glu Met Gln Val Asn 
145                 150                 155                 160 


Leu Glu Leu Glu Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala Gln 
                165                 170                 175     


Glu Met Phe Ile Glu Gln Asn Lys Leu Lys Arg Gln Ser His Leu Leu 
            180                 185                 190         


Leu Gln Ser Ser Ile Pro Asp Gln Gln Leu Leu Lys Ala Leu Asp Glu 
        195                 200                 205             


Asn Ala Lys Leu Thr Gln Gln Leu Glu Glu Glu Arg Ile Gln His Gln 
    210                 215                 220                 


Gln Lys Val Lys Glu Leu Glu Glu Gln Leu Glu Asn Glu Thr Leu His 
225                 230                 235                 240 


Lys Glu Ile His Asn Leu Lys Gln Gln Leu Glu Leu Leu Glu Glu Asp 
                245                 250                 255     


Lys Lys Glu Leu Glu Leu Lys Tyr Gln Asn Ser Glu Glu Lys Ala Arg 
            260                 265                 270         


Asn Leu Lys His Ser Val Asp Glu Leu Gln Lys Arg Val Asn Gln Ser 
        275                 280                 285             


Glu Asn Ser Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro 
    290                 295                 300                 


Pro Pro Pro Asn Pro Ile Arg Ser Leu Met Ser Met Ile Arg Lys Arg 
305                 310                 315                 320 


Ser His Pro Ser Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gln Pro 
                325                 330                 335     


Glu Thr Thr Glu Glu Val Thr Asp Leu Lys Arg Gln Ala Val Glu Glu 
            340                 345                 350         


Met Met Asp Arg Ile Lys Lys Gly Val His Leu Arg Pro Val Asn Gln 
        355                 360                 365             


Thr Ala Arg Pro Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser 
    370                 375                 380                 


Ala Val Asp Glu Leu Lys Gly Ile Leu Gly Thr Leu Asn Lys Ser Thr 
385                 390                 395                 400 


Ser Ser Arg Ser Leu Lys Ser Leu Asp Pro Glu Asn Ser Glu Thr Glu 
                405                 410                 415     


Leu Glu Arg Ile Leu Arg Arg Arg Lys Val Thr Ala Glu Ala Asp Ser 
            420                 425                 430         


Ser Ser Pro Thr Gly Ile Leu Ala Thr Ser Glu Ser Lys Ser Met Pro 
        435                 440                 445             


Val Leu Gly Ser Val Ser Ser Val Thr Lys Thr Ala Leu Asn Lys Lys 
    450                 455                 460                 


Thr Leu Glu Ala Glu Phe Asn Ser Pro Ser Pro Pro Thr Pro Glu Pro 
465                 470                 475                 480 


Gly Glu Gly Pro Arg Lys Leu Glu Gly Cys Thr Ser Ser Lys Val Thr 
                485                 490                 495     


Phe Gln 
        


<210> 6806
<211> 649
<212> PRT
<213> Homo sapiens

<400> 6806
Met Asn Ser Ser Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu 
1               5                   10                  15      


Lys Glu Gln Ala Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln 
            20                  25                  30          


Lys Thr Lys Glu Lys Cys Asp Lys Ile Arg Gln Glu Arg Asp Glu Ala 
        35                  40                  45              


Val Lys Lys Leu Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu 
    50                  55                  60                  


Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg 
65                  70                  75                  80  


Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr 
                85                  90                  95      


Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val 
            100                 105                 110         


Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr 
        115                 120                 125             


Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile 
    130                 135                 140                 


Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Lys Leu Val Glu Val Ile 
                165                 170                 175     


Glu Glu Val Asn Lys Val Lys Gln Glu Lys Thr Val Leu Asn Ser Glu 
            180                 185                 190         


Val Leu Glu Gln Arg Lys Val Leu Glu Lys Cys Asn Arg Val Ser Met 
        195                 200                 205             


Leu Ala Val Glu Glu Tyr Glu Glu Met Gln Val Asn Leu Glu Leu Glu 
    210                 215                 220                 


Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala Gln Glu Met Phe Ile 
225                 230                 235                 240 


Glu Gln Asn Lys Leu Lys Arg Gln Ser His Leu Leu Leu Gln Ser Ser 
                245                 250                 255     


Ile Pro Asp Gln Gln Leu Leu Lys Ala Leu Asp Glu Asn Ala Lys Leu 
            260                 265                 270         


Thr Gln Gln Leu Glu Glu Glu Arg Ile Gln His Gln Gln Lys Val Lys 
        275                 280                 285             


Glu Leu Glu Glu Gln Leu Glu Asn Glu Thr Leu His Lys Glu Ile His 
    290                 295                 300                 


Asn Leu Lys Gln Gln Leu Glu Leu Leu Glu Glu Asp Lys Lys Glu Leu 
305                 310                 315                 320 


Glu Leu Lys Tyr Gln Asn Ser Glu Glu Lys Ala Arg Asn Leu Lys His 
                325                 330                 335     


Ser Val Asp Glu Leu Gln Lys Arg Val Asn Gln Ser Glu Asn Ser Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Asn 
        355                 360                 365             


Pro Ile Arg Ser Leu Met Ser Met Ile Arg Lys Arg Ser His Pro Ser 
    370                 375                 380                 


Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gln Pro Glu Thr Thr Glu 
385                 390                 395                 400 


Glu Val Thr Asp Leu Lys Arg Gln Ala Val Glu Glu Met Met Asp Arg 
                405                 410                 415     


Ile Lys Lys Gly Val His Leu Arg Pro Val Asn Gln Thr Ala Arg Pro 
            420                 425                 430         


Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser Ala Val Asp Glu 
        435                 440                 445             


Leu Lys Gly Ile Leu Gly Thr Leu Asn Lys Ser Thr Ser Ser Arg Ser 
    450                 455                 460                 


Leu Lys Ser Leu Asp Pro Glu Asn Ser Glu Thr Glu Leu Glu Arg Ile 
465                 470                 475                 480 


Leu Arg Arg Arg Lys Val Thr Ala Glu Ala Asp Ser Ser Ser Pro Thr 
                485                 490                 495     


Gly Ile Leu Ala Thr Ser Glu Ser Lys Ser Met Pro Val Leu Gly Ser 
            500                 505                 510         


Val Ser Ser Val Thr Lys Thr Ala Leu Asn Lys Lys Thr Leu Glu Ala 
        515                 520                 525             


Glu Phe Asn Ser Pro Ser Pro Pro Thr Pro Glu Pro Gly Glu Gly Pro 
    530                 535                 540                 


Arg Lys Leu Glu Gly Cys Thr Ser Ser Lys Val Thr Phe Gln Pro Pro 
545                 550                 555                 560 


Ser Ser Ile Gly Cys Arg Lys Lys Tyr Ile Asp Gly Glu Lys Gln Ala 
                565                 570                 575     


Glu Pro Val Val Val Leu Asp Pro Val Ser Thr His Glu Pro Gln Thr 
            580                 585                 590         


Lys Asp Gln Val Ala Glu Lys Asp Pro Thr Gln His Lys Glu Asp Glu 
        595                 600                 605             


Gly Glu Ile Gln Pro Glu Asn Lys Glu Asp Ser Ile Glu Asn Phe Phe 
    610                 615                 620                 


Pro Phe His Phe Gly Phe Glu Gly Val Leu Pro Leu Ala Gly Val Thr 
625                 630                 635                 640 


Leu Ser Thr Lys Ala Arg Asp Pro Lys 
                645                 


<210> 6807
<211> 278
<212> PRT
<213> Homo sapiens

<400> 6807
Met Gly Lys Ser Ser Glu Trp Cys Glu Arg Ile Ala Gly Ile Gln Lys 
1               5                   10                  15      


Phe Val Leu Glu Lys Trp Thr Lys Lys Ala Lys Pro Glu Asp Thr Leu 
            20                  25                  30          


Asn Leu Cys Gln Leu Leu Asn Asn Asp Leu Ala Ser Thr Val Val Ser 
        35                  40                  45              


Tyr Pro Arg Arg Phe Val Gly Leu Gly Thr Leu Pro Met Gln Ala Pro 
    50                  55                  60                  


Glu Leu Ala Val Lys Glu Met Glu Arg Cys Val Lys Glu Leu Gly Phe 
65                  70                  75                  80  


Pro Gly Val Gln Ile Gly Thr His Val Asn Glu Trp Asp Leu Asn Ala 
                85                  90                  95      


Gln Glu Leu Phe Pro Val Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser 
            100                 105                 110         


Leu Phe Val His Pro Trp Asp Met Gln Met Asp Gly Arg Met Ala Lys 
        115                 120                 125             


Tyr Trp Leu Pro Trp Leu Val Gly Met Pro Ala Glu Thr Thr Ile Ala 
    130                 135                 140                 


Ile Cys Ser Met Ile Met Gly Gly Val Phe Glu Lys Phe Pro Lys Leu 
145                 150                 155                 160 


Lys Val Cys Phe Ala His Gly Gly Gly Ala Phe Pro Phe Thr Val Gly 
                165                 170                 175     


Arg Ile Ser His Gly Phe Ser Met Arg Pro Asp Leu Cys Ala Gln Asp 
            180                 185                 190         


Asn Pro Met Asn Pro Lys Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala 
        195                 200                 205             


Leu Val His Asp Pro Leu Ser Leu Lys Leu Leu Thr Asp Val Ile Gly 
    210                 215                 220                 


Lys Asp Lys Val Ile Leu Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu 
225                 230                 235                 240 


Leu Glu Pro Gly Lys Leu Ile Glu Ser Met Glu Glu Phe Asp Glu Glu 
                245                 250                 255     


Thr Lys Asn Lys Leu Lys Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu 
            260                 265                 270         


Glu Arg Lys Gln Phe Glu 
        275             


<210> 6808
<211> 455
<212> PRT
<213> Homo sapiens

<400> 6808
Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
1               5                   10                  15      


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu 
            20                  25                  30          


Pro Asn Ile Arg Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu 
        35                  40                  45              


Ile Arg Arg Thr Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser 
    50                  55                  60                  


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
65                  70                  75                  80  


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
                85                  90                  95      


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
            100                 105                 110         


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
        115                 120                 125             


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
    130                 135                 140                 


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
145                 150                 155                 160 


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
                165                 170                 175     


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
            180                 185                 190         


Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr Lys Gln His 
        195                 200                 205             


Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile Ile Lys Phe 
    210                 215                 220                 


Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu Thr Pro Lys 
225                 230                 235                 240 


Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala Val Val Gly 
                245                 250                 255     


Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp Asp Glu Glu 
            260                 265                 270         


Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met Lys Leu Asn 
        275                 280                 285             


Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu Lys Glu Ser 
    290                 295                 300                 


Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser Pro Ile Asn 
305                 310                 315                 320 


Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu Pro Gly Tyr 
                325                 330                 335     


Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe Ala Gln Tyr 
            340                 345                 350         


Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Tyr Gln Thr Leu 
        355                 360                 365             


Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly Val Ser Met 
    370                 375                 380                 


Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met Leu Met Val 
385                 390                 395                 400 


Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp Arg Thr Arg 
                405                 410                 415     


Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile Phe Gly Met 
            420                 425                 430         


Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg Asn Asp Met 
        435                 440                 445             


Lys Lys Lys Ala Lys Leu Phe 
    450                 455 


<210> 6809
<211> 652
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6809
Xaa Ser His Ala Phe Ile Ser Gln Trp Val Cys Arg His Trp Arg Asp 
1               5                   10                  15      


Pro Val Ala His Pro Gln Asp Pro His His Pro Ser Glu Lys Pro Val 
            20                  25                  30          


Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly Glu Val Leu Arg 
        35                  40                  45              


Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr Cys Lys Val Cys 
    50                  55                  60                  


Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys Asn Gly Glu Tyr 
65                  70                  75                  80  


Leu Cys Thr Leu Asp Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys 
                85                  90                  95      


Lys Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp 
            100                 105                 110         


Cys Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu 
        115                 120                 125             


Thr Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn 
    130                 135                 140                 


Gly Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe 
145                 150                 155                 160 


Lys Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys 
                165                 170                 175     


Asp Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val 
            180                 185                 190         


Lys Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala 
        195                 200                 205             


Gly Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn 
    210                 215                 220                 


Gln Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val 
225                 230                 235                 240 


Trp His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg 
                245                 250                 255     


Pro Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser 
            260                 265                 270         


Ile Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu 
        275                 280                 285             


Ile Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile 
    290                 295                 300                 


Tyr Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr 
305                 310                 315                 320 


Ser Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro 
                325                 330                 335     


Arg Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg 
            340                 345                 350         


Asp Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro 
        355                 360                 365             


Val Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln 
    370                 375                 380                 


His Phe His Arg Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro 
385                 390                 395                 400 


Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu 
                405                 410                 415     


Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro 
            420                 425                 430         


Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser 
        435                 440                 445             


Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu 
    450                 455                 460                 


Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln 
465                 470                 475                 480 


Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu 
                485                 490                 495     


Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr 
            500                 505                 510         


Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala 
        515                 520                 525             


Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr 
    530                 535                 540                 


Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg 
545                 550                 555                 560 


Asp Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg Met Asp 
                565                 570                 575     


Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr 
            580                 585                 590         


Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu 
        595                 600                 605             


Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg 
    610                 615                 620                 


Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp 
625                 630                 635                 640 


Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
                645                 650         


<210> 6810
<211> 278
<212> PRT
<213> Homo sapiens

<400> 6810
Met Thr Gln Gln Trp Arg Glu Val Asn Glu Asp Arg Glu Ala Val Ala 
1               5                   10                  15      


Gln Ala Arg Ser Trp Gln Ser Leu Asn Leu Gly Asp Arg Asp Met Gly 
            20                  25                  30          


Val Ser Phe Ile Glu Thr Ala Leu Ala Leu Ser Ala Ala Arg Ala Arg 
        35                  40                  45              


Arg Pro Leu Leu Thr Ser His Pro Pro Ser Arg Pro Phe Gln Pro Pro 
    50                  55                  60                  


Lys His Thr Pro Ser Pro Pro Pro Ala Pro Arg Val Asn Ser Arg His 
65                  70                  75                  80  


Pro Gly Arg Ser Val Ser Leu Ser Leu Pro Ser Ala Ser Gln Ala Pro 
                85                  90                  95      


Pro Val Pro Leu Ala Ser Pro Glu Gly Arg Pro His Thr Val Gly Ala 
            100                 105                 110         


Pro His Ala Ser Thr Trp Lys Arg Thr Arg Gly Arg Gln Arg Ala Arg 
        115                 120                 125             


Pro Pro Lys Ile Val Lys Glu Ala Glu Val Pro Gln Ala Ala Leu Gly 
    130                 135                 140                 


Val Pro Ala Gln Gly Thr Gly Asp Asn Gly His Thr Pro Val Glu Glu 
145                 150                 155                 160 


Glu Val Gly Gly Ile Pro Val Pro Ala Pro Gly Leu Leu Gln Val Thr 
                165                 170                 175     


Glu Arg Arg Gln Pro Leu Ser Ser Val Ser Ser Leu Glu Val His Phe 
            180                 185                 190         


Asp Leu Leu Asp Leu Thr Glu Leu Thr Asp Met Ser Asp Gln Glu Leu 
        195                 200                 205             


Ala Glu Val Phe Ala Asp Ser Asp Asp Glu Asn Leu Asn Thr Glu Ser 
    210                 215                 220                 


Pro Ala Gly Leu His Pro Leu Pro Arg Ala Gly Tyr Leu Arg Ser Pro 
225                 230                 235                 240 


Ser Trp Thr Arg Thr Arg Ala Glu Gln Ser His Glu Lys Gln Pro Leu 
                245                 250                 255     


Gly Asp Pro Glu Arg Gln Ala Thr Val Leu Asp Thr Phe Leu Thr Val 
            260                 265                 270         


Glu Arg Pro Gln Glu Asp 
        275             


<210> 6811
<211> 179
<212> PRT
<213> Homo sapiens

<400> 6811
Met Thr Asp Leu Val Ala Val Trp Asp Val Ala Leu Ser Asp Gly Val 
1               5                   10                  15      


His Lys Ile Glu Phe Glu His Gly Thr Thr Ser Gly Lys Arg Val Val 
            20                  25                  30          


Tyr Val Asp Gly Lys Glu Glu Ile Arg Lys Glu Trp Met Phe Lys Leu 
        35                  40                  45              


Val Gly Lys Glu Thr Phe Tyr Val Gly Ala Ala Lys Thr Lys Ala Thr 
    50                  55                  60                  


Ile Asn Ile Asp Ala Ile Ser Gly Phe Ala Tyr Glu Tyr Thr Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Lys Ser Leu Lys Lys Tyr Met Glu Asp Arg Ser Lys Thr 
                85                  90                  95      


Thr Asn Thr Trp Val Leu His Met Asp Gly Glu Asn Phe Arg Ile Val 
            100                 105                 110         


Leu Glu Lys Asp Ala Met Asp Val Trp Cys Asn Gly Lys Lys Leu Glu 
        115                 120                 125             


Thr Ala Gly Glu Phe Val Asp Asp Gly Thr Glu Thr His Phe Ser Ile 
    130                 135                 140                 


Gly Asn His Asp Cys Tyr Ile Lys Ala Val Ser Ser Gly Lys Arg Lys 
145                 150                 155                 160 


Glu Gly Ile Ile His Thr Leu Ile Val Asp Asn Arg Glu Ile Pro Glu 
                165                 170                 175     


Ile Ala Ser 
            


<210> 6812
<211> 179
<212> PRT
<213> Homo sapiens

<400> 6812
Met Thr Asp Leu Val Ala Val Trp Asp Val Ala Leu Ser Asp Gly Val 
1               5                   10                  15      


His Lys Ile Glu Phe Glu His Gly Thr Thr Ser Gly Lys Arg Val Val 
            20                  25                  30          


Tyr Val Asp Gly Lys Glu Glu Ile Arg Lys Glu Trp Met Phe Lys Leu 
        35                  40                  45              


Val Gly Lys Glu Thr Phe Tyr Val Gly Ala Ala Lys Thr Lys Ala Thr 
    50                  55                  60                  


Ile Asn Ile Asp Ala Ile Ser Gly Phe Ala Tyr Glu Tyr Thr Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Lys Ser Leu Lys Lys Tyr Met Glu Asp Arg Ser Lys Thr 
                85                  90                  95      


Thr Asn Thr Trp Val Leu His Met Asp Gly Glu Asn Phe Arg Ile Val 
            100                 105                 110         


Leu Glu Lys Asp Ala Met Asp Val Trp Cys Asn Gly Lys Lys Leu Glu 
        115                 120                 125             


Thr Ala Gly Glu Phe Val Asp Asp Gly Thr Glu Thr His Phe Ser Ile 
    130                 135                 140                 


Gly Asn His Asp Cys Tyr Ile Lys Ala Val Ser Ser Gly Lys Arg Lys 
145                 150                 155                 160 


Glu Gly Ile Ile His Thr Leu Ile Val Asp Asn Arg Glu Ile Pro Glu 
                165                 170                 175     


Ile Ala Ser 
            


<210> 6813
<211> 350
<212> PRT
<213> Homo sapiens

<400> 6813
Met Gly Pro Cys Asn Leu Ser Ser Ala Ala Gly Pro Thr Ala Glu Lys 
1               5                   10                  15      


Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu Gly Gln Gly Thr Ser Val 
            20                  25                  30          


Val Ala Gln Gly Pro Ser Arg Pro Leu Pro Ser Thr Ala Asn Val Val 
        35                  40                  45              


Val Ile Gly Gly Gly Ser Leu Gly Cys Gln Thr Leu Tyr His Leu Ala 
    50                  55                  60                  


Lys Leu Gly Met Ser Gly Ala Val Leu Leu Glu Arg Glu Arg Leu Thr 
65                  70                  75                  80  


Ser Gly Thr Thr Trp His Thr Ala Gly Leu Leu Trp Gln Leu Arg Pro 
                85                  90                  95      


Ser Asp Val Glu Val Glu Leu Leu Ala His Thr Arg Arg Val Val Ser 
            100                 105                 110         


Arg Glu Leu Glu Glu Glu Thr Gly Leu His Thr Gly Trp Ile Gln Asn 
        115                 120                 125             


Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln Arg Leu Asp Glu Tyr Lys 
    130                 135                 140                 


Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly Val Glu Ser His Val Leu 
145                 150                 155                 160 


Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro Leu Met Asn Val Asp Asp 
                165                 170                 175     


Leu Tyr Gly Thr Leu Tyr Val Pro His Asp Gly Thr Met Asp Pro Ala 
            180                 185                 190         


Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala Ser Ala Arg Gly Ala Gln 
        195                 200                 205             


Val Ile Glu Asn Cys Pro Val Thr Gly Ile Arg Val Trp Thr Asp Asp 
    210                 215                 220                 


Phe Gly Val Arg Arg Val Ala Gly Val Glu Thr Gln His Gly Ser Ile 
225                 230                 235                 240 


Gln Thr Pro Cys Val Val Asn Cys Ala Gly Val Trp Ala Ser Ala Val 
                245                 250                 255     


Gly Arg Met Ala Gly Val Lys Val Pro Leu Val Ala Met His His Ala 
            260                 265                 270         


Tyr Val Val Thr Glu Arg Ile Glu Gly Ile Gln Asn Met Pro Asn Val 
        275                 280                 285             


Arg Asp His Asp Ala Ser Val Tyr Leu Arg Leu Gln Gly Asp Ala Leu 
    290                 295                 300                 


Ser Val Gly Gly Tyr Glu Ala Asn Pro Ile Phe Trp Glu Glu Ala Val 
305                 310                 315                 320 


Lys Tyr Arg Pro Arg Ala Ala Gly Gly Leu Cys Leu Lys Thr Ser Thr 
                325                 330                 335     


Glu Lys Val Cys Ala Val Trp Ser Asp Asp Leu Arg Arg Ala 
            340                 345                 350 


<210> 6814
<211> 666
<212> PRT
<213> Homo sapiens

<400> 6814
Met Ala Arg Ala Gly Ser Cys Gly Gly Ala Ala Ala Gly Ala Gly Arg 
1               5                   10                  15      


Pro Glu Pro Trp Glu Leu Ser Leu Glu Glu Val Leu Lys Ala Tyr Glu 
            20                  25                  30          


Gln Pro Leu Asn Glu Glu Gln Ala Trp Ala Val Cys Phe Gln Gly Cys 
        35                  40                  45              


Arg Gly Leu Arg Gly Ser Pro Gly Arg Arg Leu Arg Asp Thr Gly Asp 
    50                  55                  60                  


Leu Leu Leu Arg Gly Asp Gly Ser Val Gly Ala Arg Glu Pro Glu Ala 
65                  70                  75                  80  


Ala Glu Pro Ala Thr Met Val Val Pro Leu Ala Ser Ser Glu Ala Gln 
                85                  90                  95      


Thr Val Gln Ser Leu Gly Phe Ala Ile Tyr Arg Ala Leu Asp Trp Gly 
            100                 105                 110         


Leu Asp Glu Ser Glu Glu Arg Glu Leu Ser Pro Gln Leu Glu Arg Leu 
        115                 120                 125             


Ile Asp Leu Met Ala Asn Asn Asp Ser Glu Asp Ser Gly Cys Gly Ala 
    130                 135                 140                 


Ala Asp Glu Gly Tyr Gly Gly Pro Glu Glu Glu Glu Glu Ala Glu Gly 
145                 150                 155                 160 


Val Pro Arg Ser Val Arg Thr Phe Ala Gln Ala Met Arg Leu Cys Ala 
                165                 170                 175     


Ala Arg Leu Thr Asp Pro Arg Gly Ala Gln Ala His Tyr Gln Ala Val 
            180                 185                 190         


Cys Arg Ala Leu Phe Val Glu Thr Leu Glu Leu Arg Ala Phe Leu Ala 
        195                 200                 205             


Arg Val Arg Glu Ala Lys Glu Met Leu Gln Lys Leu Arg Glu Asp Glu 
    210                 215                 220                 


Pro His Leu Glu Thr Pro Arg Ala Glu Leu Asp Ser Leu Gly His Thr 
225                 230                 235                 240 


Asp Trp Ala Arg Leu Trp Val Gln Leu Met Arg Glu Leu Arg Arg Gly 
                245                 250                 255     


Val Lys Leu Lys Lys Val Gln Glu Gln Glu Phe Asn Pro Leu Pro Thr 
            260                 265                 270         


Glu Phe Gln Leu Thr Pro Phe Glu Met Leu Met Gln Asp Ile Arg Ala 
        275                 280                 285             


Arg Asn Tyr Lys Leu Arg Lys Val Met Val Asp Gly Asp Ile Pro Pro 
    290                 295                 300                 


Arg Val Lys Lys Asp Ala His Glu Leu Ile Leu Asp Phe Ile Arg Ser 
305                 310                 315                 320 


Arg Pro Pro Leu Lys Gln Val Ser Glu Arg Arg Leu Arg Pro Leu Pro 
                325                 330                 335     


Pro Lys Gln Arg Ser Leu His Glu Lys Ile Leu Glu Glu Ile Lys Gln 
            340                 345                 350         


Glu Arg Arg Leu Arg Pro Val Arg Gly Glu Gly Trp Ala Ala Arg Gly 
        355                 360                 365             


Phe Gly Ser Leu Pro Cys Ile Leu Asn Ala Cys Ser Gly Asp Ala Lys 
    370                 375                 380                 


Ser Thr Ser Cys Ile Asn Leu Ser Val Thr Asp Ala Gly Gly Ser Ala 
385                 390                 395                 400 


Gln Arg Pro Arg Pro Arg Val Leu Leu Lys Ala Pro Thr Leu Ala Glu 
                405                 410                 415     


Met Glu Glu Met Asn Thr Ser Glu Glu Glu Glu Ser Pro Cys Gly Glu 
            420                 425                 430         


Val Thr Leu Lys Arg Asp Arg Ser Phe Ser Glu His Asp Leu Ala Gln 
        435                 440                 445             


Leu Arg Ser Glu Val Ala Ser Gly Leu Gln Ser Ala Thr His Pro Pro 
    450                 455                 460                 


Gly Gly Thr Glu Pro Pro Arg Pro Arg Ala Gly Ser Ala His Val Trp 
465                 470                 475                 480 


Arg Pro Gly Ser Arg Asp Gln Gly Thr Cys Pro Ala Ser Val Ser Asp 
                485                 490                 495     


Pro Ser His Pro Leu Leu Ser Asn Arg Gly Ser Ser Gly Asp Arg Pro 
            500                 505                 510         


Glu Ala Ser Met Thr Pro Asp Ala Lys His Leu Trp Leu Glu Phe Ser 
        515                 520                 525             


His Pro Val Glu Ser Leu Ala Leu Thr Val Glu Glu Val Met Asp Val 
    530                 535                 540                 


Arg Arg Val Leu Val Lys Ala Glu Met Glu Lys Phe Leu Gln Asn Lys 
545                 550                 555                 560 


Glu Leu Phe Ser Ser Leu Lys Lys Gly Lys Ile Cys Cys Cys Cys Arg 
                565                 570                 575     


Ala Lys Phe Pro Leu Phe Ser Trp Pro Pro Ser Cys Leu Phe Cys Lys 
            580                 585                 590         


Arg Ser Leu Gln Gly Pro Gln Trp Gln Ser Val Glu Glu Ala Phe Pro 
        595                 600                 605             


His Ile Tyr Ser His Gly Cys Val Leu Lys Asp Val Cys Ser Glu Cys 
    610                 615                 620                 


Thr Ser Phe Val Ala Asp Val Val Arg Ser Ser Arg Lys Ser Val Asp 
625                 630                 635                 640 


Val Leu Asn Thr Thr Pro Arg Arg Ser Arg Gln Thr Gln Ser Leu Tyr 
                645                 650                 655     


Ile Pro Asn Thr Arg Thr Leu Asp Phe Lys 
            660                 665     


<210> 6815
<211> 157
<212> PRT
<213> Homo sapiens

<400> 6815
Met Glu Thr Leu Gln Ser Glu Thr Lys Thr Arg Val Leu Pro Ser Trp 
1               5                   10                  15      


Leu Thr Ala Gln Val Ala Thr Lys Asn Val Ala Pro Met Lys Ala Pro 
            20                  25                  30          


Lys Arg Met Arg Met Ala Ala Val Pro Val Ala Ala Ala Arg Leu Pro 
        35                  40                  45              


Ala Thr Arg Thr Val Tyr Cys Met Asn Glu Ala Glu Ile Val Asp Val 
    50                  55                  60                  


Ala Leu Gly Ile Leu Ile Glu Ser Arg Lys Gln Glu Lys Ala Cys Glu 
65                  70                  75                  80  


Gln Pro Ala Leu Ala Gly Ala Asp Asn Pro Glu His Ser Pro Pro Cys 
                85                  90                  95      


Ser Val Ser Pro His Thr Ser Ser Gly Ser Ser Ser Glu Glu Glu Asp 
            100                 105                 110         


Ser Gly Lys Gln Ala Leu Ala Pro Gly Leu Ser Pro Ser Gln Arg Pro 
        115                 120                 125             


Gly Gly Ser Ser Ser Ala Cys Ser Arg Ser Pro Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Asp Val Leu Lys Tyr Val Arg Glu Ile Phe Phe Ser 
145                 150                 155         


<210> 6816
<211> 267
<212> PRT
<213> Homo sapiens

<400> 6816
Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Thr Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro 
        115                 120                 125             


Asp Gly Val Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu 
    130                 135                 140                 


Gln Lys Gly Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu 
145                 150                 155                 160 


Glu His Leu Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe 
                165                 170                 175     


Pro Gly Leu Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val 
            180                 185                 190         


Trp Glu Gly Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu 
        195                 200                 205             


Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys 
    210                 215                 220                 


Ile Gln Val Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser 
225                 230                 235                 240 


Ala Glu Lys Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp 
                245                 250                 255     


Tyr Lys Ser Cys Ala His Asp Trp Val Tyr Glu 
            260                 265         


<210> 6817
<211> 292
<212> PRT
<213> Homo sapiens

<400> 6817
Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Thr Met Ala Asn Leu 
    130                 135                 140                 


Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu 
145                 150                 155                 160 


Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val 
                165                 170                 175     


Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu Lys Gln His Tyr 
            180                 185                 190         


Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu Val Lys Tyr Met 
        195                 200                 205             


Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val 
    210                 215                 220                 


Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys 
225                 230                 235                 240 


Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile 
                245                 250                 255     


Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys Glu Ile Ser Leu 
            260                 265                 270         


Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser Cys Ala His Asp 
        275                 280                 285             


Trp Val Tyr Glu 
    290         


<210> 6818
<211> 163
<212> PRT
<213> Homo sapiens

<400> 6818
Met Lys Ser Ser Gln Thr Phe Glu Glu Gln Thr Glu Cys Ile Val Asn 
1               5                   10                  15      


Thr Leu Leu Met Asp Phe Leu Ser Pro Thr Leu Gln Val Ala Ser Arg 
            20                  25                  30          


Asn Leu Cys Cys Val Asp Glu Val Asp Ser Gly Glu Pro Cys Ser Phe 
        35                  40                  45              


Asp Val Ala Ile Ile Ala Gly Arg Leu Arg Met Leu Gly Asp Gln Phe 
    50                  55                  60                  


Asn Gly Glu Leu Glu Ala Ser Ala Lys Asn Val Ile Ala Glu Thr Ile 
65                  70                  75                  80  


Lys Gly Gln Thr Gly Ala Ile Leu Gln Asp Thr Val Glu Ser Leu Ser 
                85                  90                  95      


Lys Thr Trp Cys Ala Gln Asp Ser Ser Leu Ala Tyr Glu Arg Ala Phe 
            100                 105                 110         


Leu Ala Val Ser Val Lys Leu Leu Glu Tyr Met Ala His Ile Ala Pro 
        115                 120                 125             


Glu Val Val Gly Gln Val Ala Ile Pro Met Thr Gly Met Ile Asn Gly 
    130                 135                 140                 


Asn Gln Ala Ile Arg Glu Phe Ile Gln Gly Gln Gly Gly Trp Glu Asn 
145                 150                 155                 160 


Leu Glu Ser 
            


<210> 6819
<211> 185
<212> PRT
<213> Homo sapiens

<400> 6819
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Thr Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Thr Ala His Glu Thr Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly 
            100                 105                 110         


Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Thr Asp Ser 
        115                 120                 125             


Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asn Ser Asp Glu Ala 
    130                 135                 140                 


Asp Leu Val Pro Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Val Val 
145                 150                 155                 160 


Ile Ser Phe Tyr Glu Glu Arg Leu Thr Trp His Ser Tyr Pro Ser Glu 
                165                 170                 175     


Asp Asp Asp Lys Lys Asp Asp Lys Asn 
            180                 185 


<210> 6820
<211> 449
<212> PRT
<213> Homo sapiens

<400> 6820
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210> 6821
<211> 246
<212> PRT
<213> Homo sapiens

<400> 6821
Met Ser Gly Ala Gly Glu Ala Leu Ala Pro Gly Pro Val Gly Pro Gln 
1               5                   10                  15      


Arg Val Ala Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala Gln Gly 
            20                  25                  30          


Lys Cys Asp Lys Asp Asn Thr Glu Lys Asp Ile Thr Gln Ala Thr Asn 
        35                  40                  45              


Ser His Phe Thr His Gly Glu Met Gln Asp Gln Ser Ile Trp Gly Asn 
    50                  55                  60                  


Pro Ser Asp Gly Glu Leu Ile Arg Thr Gln Pro Gln Arg Leu Pro Gln 
65                  70                  75                  80  


Leu Gln Thr Ser Ala Gln Val Pro Ser Gly Glu Glu Ile Gly Lys Ile 
                85                  90                  95      


Lys Asn Gly His Thr Gly Leu Ser Asn Gly Asn Gly Ile His His Gly 
            100                 105                 110         


Ala Lys His Gly Ser Ala Asp Asn Arg Lys Leu Ser Ala Pro Val Ser 
        115                 120                 125             


Gln Lys Met His Arg Lys Ile Gln Ser Ser Leu Ser Val Asn Ser Asp 
    130                 135                 140                 


Ile Ser Lys Lys Ser Lys Val Asn Ala Val Phe Ser Gln Lys Thr Gly 
145                 150                 155                 160 


Ser Ser Pro Glu Asp Cys Cys Val His Cys Ile Leu Ala Cys Leu Phe 
                165                 170                 175     


Cys Glu Phe Leu Thr Leu Cys Asn Ile Val Leu Gly Gln Ala Ser Cys 
            180                 185                 190         


Gly Ile Cys Thr Ser Glu Ala Cys Cys Cys Cys Cys Gly Asp Glu Met 
        195                 200                 205             


Gly Asp Asp Cys Asn Cys Pro Cys Asp Met Asp Cys Gly Ile Met Asp 
    210                 215                 220                 


Ala Cys Cys Glu Ser Ser Asp Cys Leu Glu Ile Cys Met Glu Cys Cys 
225                 230                 235                 240 


Gly Ile Cys Phe Pro Ser 
                245     


<210> 6822
<211> 9
<212> PRT
<213> Homo sapiens

<400> 6822
Met Ser Tyr Tyr Gln Arg Pro Phe Ser 
1               5                   


<210> 6823
<211> 666
<212> PRT
<213> Homo sapiens

<400> 6823
Met Asn Thr Gly Arg Asp Ser Gln Ser Pro Asp Ser Ala Lys Gly Phe 
1               5                   10                  15      


Arg Ser Val Arg Pro Asn Leu Gln Asp Lys Arg Ser Pro Thr Gln Ser 
            20                  25                  30          


Gln Ile Thr Val Asn Gly Asn Ser Gly Gly Ala Val Ser Pro Met Ser 
        35                  40                  45              


Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro Ala Ser 
    50                  55                  60                  


Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp Ser Thr 
65                  70                  75                  80  


Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr Ser Ser 
                85                  90                  95      


Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val Thr Val 
            100                 105                 110         


Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu Ser Gly 
        115                 120                 125             


Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp Trp Tyr 
    130                 135                 140                 


Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Asp Asp Asp 
145                 150                 155                 160 


Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn Ala Gly Leu Tyr Asn 
                165                 170                 175     


Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln Thr Tyr 
            180                 185                 190         


Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala Phe Lys 
        195                 200                 205             


Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro Val Pro 
    210                 215                 220                 


Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp Trp Asp 
225                 230                 235                 240 


Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu Pro Arg 
                245                 250                 255     


Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln His Glu 
            260                 265                 270         


Arg Pro Thr Asp Arg Ile Asn Pro Asp Asp Ile Asp Leu Glu Asn Glu 
        275                 280                 285             


Pro Trp Tyr Lys Phe Phe Ser Glu Leu Glu Phe Gly Arg Pro Pro Pro 
    290                 295                 300                 


Lys Lys Pro Leu Asp Tyr Val Gln Asp His Ser Ser Gly Val Phe Asn 
305                 310                 315                 320 


Glu Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu Glu Arg Pro 
                325                 330                 335     


Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg Arg Lys Ser 
            340                 345                 350         


Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln Ser Ala Ser 
        355                 360                 365             


Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser Thr Thr Leu 
    370                 375                 380                 


Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser Arg Ala Lys 
385                 390                 395                 400 


Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp Met Gly 
                405                 410                 415     


Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu Lys Leu 
            420                 425                 430         


Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys Glu Leu 
        435                 440                 445             


Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile Asp Gln 
    450                 455                 460                 


Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe Pro Ile 
465                 470                 475                 480 


Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro Ala Arg 
                485                 490                 495     


Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile Ala Lys 
            500                 505                 510         


Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg Lys Gly 
        515                 520                 525             


Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr Glu Gly 
    530                 535                 540                 


Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser Tyr Val 
545                 550                 555                 560 


Glu Val Val Lys Lys Asn Thr Lys Gly Ala Glu Asp Tyr Pro Asp Pro 
                565                 570                 575     


Pro Ile Pro His Ser Tyr Ser Ser Asp Arg Ile His Ser Leu Ser Ser 
            580                 585                 590         


Asn Lys Pro Gln Arg Pro Val Phe Thr His Glu Asn Ile Gln Gly Gly 
        595                 600                 605             


Gly Glu Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn Glu Asp 
    610                 615                 620                 


Glu Leu Glu Leu Arg Glu Ser Asp Val Ile Asp Val Met Glu Lys Cys 
625                 630                 635                 640 


Asp Asp Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe Phe Gly 
                645                 650                 655     


Thr Phe Pro Gly Asn Tyr Val Lys Arg Leu 
            660                 665     


<210> 6824
<211> 823
<212> PRT
<213> Homo sapiens

<400> 6824
Met Thr Leu Leu Ser Ser Gln Ser Ser Ser Leu Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Val Ser Ala Glu Asn Pro Glu Gln Arg Met Leu Glu Lys Arg Ala 
            20                  25                  30          


Lys Val Ile Glu Glu Leu Leu Gln Thr Glu Arg Asp Tyr Ile Arg Asp 
        35                  40                  45              


Leu Glu Met Cys Ile Glu Arg Ile Met Val Pro Met Gln Gln Ala Gln 
    50                  55                  60                  


Val Pro Asn Ile Asp Phe Glu Gly Leu Phe Gly Asn Met Gln Met Val 
65                  70                  75                  80  


Ile Lys Val Ser Lys Gln Leu Leu Ala Ala Leu Glu Ile Ser Asp Ala 
                85                  90                  95      


Val Gly Pro Val Phe Leu Gly His Arg Asp Glu Leu Glu Gly Thr Tyr 
            100                 105                 110         


Lys Ile Tyr Cys Gln Asn His Asp Glu Ala Ile Ala Leu Leu Glu Ile 
        115                 120                 125             


Tyr Glu Lys Asp Glu Lys Ile Gln Lys His Leu Gln Asp Ser Leu Ala 
    130                 135                 140                 


Asp Leu Asn Ser Leu Val Leu Lys Lys Gly Cys Thr Asn Tyr Ile Asn 
145                 150                 155                 160 


Leu Gly Ser Phe Leu Ile Lys Pro Val Gln Arg Val Met Arg Tyr Pro 
                165                 170                 175     


Leu Leu Leu Met Glu Leu Leu Asn Ser Thr Pro Glu Ser His Pro Asp 
            180                 185                 190         


Lys Val Pro Leu Thr Asn Ala Val Leu Ala Val Lys Glu Ile Asn Val 
        195                 200                 205             


Asn Ile Asn Glu Tyr Lys Arg Arg Lys Asp Leu Val Leu Lys Tyr Arg 
    210                 215                 220                 


Lys Gly Asp Glu Asp Ser Leu Met Glu Lys Ile Ser Lys Leu Asn Ile 
225                 230                 235                 240 


His Ser Ile Ile Lys Lys Ser Asn Arg Val Ser Ser His Leu Lys His 
                245                 250                 255     


Leu Thr Gly Phe Ala Pro Gln Ile Lys Asp Glu Val Phe Glu Glu Thr 
            260                 265                 270         


Glu Lys Asn Phe Arg Met Gln Glu Arg Leu Ile Lys Ser Phe Ile Arg 
        275                 280                 285             


Asp Leu Ser Leu Tyr Leu Gln His Ile Arg Glu Ser Ala Cys Val Lys 
    290                 295                 300                 


Val Val Ala Ala Val Ser Met Trp Asp Val Cys Met Glu Arg Gly His 
305                 310                 315                 320 


Arg Asp Leu Glu Gln Phe Glu Arg Val His Arg Tyr Ile Ser Asp Gln 
                325                 330                 335     


Leu Phe Thr Asn Phe Lys Glu Arg Thr Glu Arg Leu Val Ile Ser Pro 
            340                 345                 350         


Leu Asn Gln Leu Leu Ser Met Phe Thr Gly Pro His Lys Leu Val Gln 
        355                 360                 365             


Lys Arg Phe Asp Lys Leu Leu Asp Phe Tyr Asn Cys Thr Glu Arg Ala 
    370                 375                 380                 


Glu Lys Leu Lys Asp Lys Lys Thr Leu Glu Glu Leu Gln Ser Ala Arg 
385                 390                 395                 400 


Asn Asn Tyr Glu Ala Leu Asn Ala Gln Leu Leu Asp Glu Leu Pro Lys 
                405                 410                 415     


Phe His Gln Tyr Ala Gln Gly Leu Phe Thr Asn Cys Val His Gly Tyr 
            420                 425                 430         


Ala Glu Ala His Cys Asp Phe Val His Gln Ala Leu Glu Gln Leu Lys 
        435                 440                 445             


Pro Leu Leu Ser Leu Leu Lys Val Ala Gly Arg Glu Gly Asn Leu Ile 
    450                 455                 460                 


Ala Ile Phe His Glu Glu His Ser Arg Val Leu Gln Gln Leu Gln Val 
465                 470                 475                 480 


Phe Thr Phe Phe Pro Glu Ser Leu Pro Ala Thr Lys Lys Pro Phe Glu 
                485                 490                 495     


Arg Lys Thr Ile Asp Arg Gln Ser Ala Arg Lys Pro Leu Leu Gly Leu 
            500                 505                 510         


Pro Ser Tyr Met Leu Gln Ser Glu Glu Leu Arg Ala Ser Leu Leu Ala 
        515                 520                 525             


Arg Tyr Pro Pro Glu Lys Leu Phe Gln Ala Glu Arg Asn Phe Asn Ala 
    530                 535                 540                 


Ala Gln Asp Leu Asp Val Ser Leu Leu Glu Gly Asp Leu Val Gly Val 
545                 550                 555                 560 


Ile Lys Lys Lys Asp Pro Met Gly Ser Gln Asn Arg Trp Leu Ile Asp 
                565                 570                 575     


Asn Gly Val Thr Lys Gly Phe Val Tyr Ser Ser Phe Leu Lys Pro Tyr 
            580                 585                 590         


Asn Pro Arg Arg Ser His Ser Asp Ala Ser Val Gly Ser His Ser Ser 
        595                 600                 605             


Thr Glu Ser Glu His Gly Ser Ser Ser Pro Arg Phe Pro Arg Gln Asn 
    610                 615                 620                 


Ser Gly Ser Thr Leu Thr Phe Asn Pro Ser Ser Met Ala Val Ser Phe 
625                 630                 635                 640 


Thr Ser Gly Ser Cys Gln Lys Gln Pro Gln Asp Ala Ser Pro Pro Pro 
                645                 650                 655     


Lys Glu Cys Asp Gln Gly Thr Leu Ser Ala Ser Leu Asn Pro Ser Asn 
            660                 665                 670         


Ser Glu Ser Ser Pro Ser Arg Cys Pro Ser Asp Pro Asp Ser Thr Ser 
        675                 680                 685             


Gln Pro Arg Ser Gly Asp Ser Ala Asp Val Ala Arg Asp Val Lys Gln 
    690                 695                 700                 


Pro Thr Ala Thr Pro Arg Ser Tyr Arg Asn Phe Arg His Pro Glu Ile 
705                 710                 715                 720 


Val Gly Tyr Ser Val Pro Gly Arg Asn Gly Gln Ser Gln Asp Leu Val 
                725                 730                 735     


Lys Gly Cys Ala Arg Thr Ala Gln Ala Pro Glu Asp Arg Ser Thr Glu 
            740                 745                 750         


Pro Asp Gly Ser Glu Ala Glu Gly Asn Gln Val Tyr Phe Ala Val Tyr 
        755                 760                 765             


Thr Phe Lys Ala Arg Asn Pro Asn Glu Leu Ser Val Ser Ala Asn Gln 
    770                 775                 780                 


Lys Leu Lys Ile Leu Glu Phe Lys Asp Val Thr Gly Asn Thr Glu Trp 
785                 790                 795                 800 


Trp Leu Ala Glu Val Asn Gly Lys Lys Gly Tyr Val Pro Ser Asn Tyr 
                805                 810                 815     


Ile Arg Lys Thr Glu Tyr Thr 
            820             


<210> 6825
<211> 987
<212> PRT
<213> Homo sapiens

<400> 6825
Met Ala Glu Ser Ser Ser Glu Ser Asp His Phe Arg Cys Arg Asp Arg 
1               5                   10                  15      


Leu Ser Pro Trp Ala Ala Arg Ser Thr His Arg Gly Thr Arg Ser Leu 
            20                  25                  30          


Pro Thr Val Glu Val Thr Glu Lys Val Asn Thr Ile Thr Ser Thr Leu 
        35                  40                  45              


Gln Asp Thr Ser Arg Asn Leu Arg Gln Val Asp Gln Met Leu Gly Arg 
    50                  55                  60                  


Tyr Arg Glu Tyr Ser Asn Gly Gln Ala Gly Ala Ile Glu His Leu Lys 
65                  70                  75                  80  


Glu Ser Leu Glu Gln Ser Ile Asp Gln Leu Arg Ser Gln Arg Leu Leu 
                85                  90                  95      


Arg Asn Ser Gly Gly Arg Ser Ile Ser Val Thr Ser Leu Ser Ala Ser 
            100                 105                 110         


Asp Leu Asp Gly Gly Thr Gly Ser Glu Leu His His Phe Pro Pro Thr 
        115                 120                 125             


Ser Pro Leu Lys Asp Tyr Gly Asp Pro Gln Gly Ile Lys Arg Met Arg 
    130                 135                 140                 


Ser Arg Thr Gly Val Arg Phe Val Gln Glu Thr Asp Asp Met Thr Gln 
145                 150                 155                 160 


Leu His Gly Phe His Gln Ser Leu Arg Asp Leu Ser Ser Glu Gln Ile 
                165                 170                 175     


Arg Leu Gly Asp Asp Phe Asn Arg Glu Leu Ser Arg Arg Ser Arg Ser 
            180                 185                 190         


Asp Ala Glu Thr Lys Arg Ala Leu Glu Glu Leu Thr Glu Lys Leu Asn 
        195                 200                 205             


Glu Ala Gln Lys Gln Glu Val Val Ser Asp Arg Val Glu Arg Arg Leu 
    210                 215                 220                 


Gln Glu Leu Glu Arg Glu Met Arg Thr Glu Arg Glu Leu Val Glu Arg 
225                 230                 235                 240 


Arg Gln Asp Gln Leu Gly Leu Met Ser Leu Gln Leu Gln Glu Ala Leu 
                245                 250                 255     


Lys Lys Gln Glu Ala Lys Ala Asp Glu His Glu Gly Ala Ile Lys Asn 
            260                 265                 270         


Lys Leu Arg Gln Thr Glu Thr Glu Lys Asn Gln Leu Glu Gln Glu Leu 
        275                 280                 285             


Glu Leu Ser Arg Arg Leu Leu Asn Gln Ser Glu Gly Ser Arg Glu Thr 
    290                 295                 300                 


Leu Leu His Gln Val Glu Glu Leu Arg Thr Gln Leu Thr Lys Ala Glu 
305                 310                 315                 320 


Gly Asp Arg Lys Gly Leu Gln His Gln Val Ser Gln Ile Ser Lys Gln 
                325                 330                 335     


Gln Ser Asn Tyr Gln Asp Glu Gln Gly Glu Asp Trp Arg Phe Arg Arg 
            340                 345                 350         


Gly Val Glu Arg Glu Lys Gln Asp Leu Glu Lys Gln Met Ser Asp Leu 
        355                 360                 365             


Arg Val Gln Leu Asn Phe Ser Ala Met Ala Ser Glu Leu Glu Glu Val 
    370                 375                 380                 


Lys Arg Cys Met Glu Arg Lys Asp Lys Glu Lys Ala His Leu Ala Ser 
385                 390                 395                 400 


Gln Val Glu Asn Leu Thr Arg Glu Leu Glu Asn Gly Glu Lys Gln Gln 
                405                 410                 415     


Leu Gln Met Leu Asp Arg Leu Lys Glu Ile Gln Asn His Phe Asp Thr 
            420                 425                 430         


Cys Glu Ala Glu Arg Lys His Ala Asp Leu Gln Ile Ser Glu Leu Thr 
        435                 440                 445             


Arg His Ala Glu Asp Ala Thr Lys Gln Ala Glu Arg Tyr Leu Ser Glu 
    450                 455                 460                 


Leu Gln Gln Ser Glu Ala Leu Lys Glu Glu Ala Glu Lys Arg Arg Glu 
465                 470                 475                 480 


Asp Leu Lys Leu Lys Ala Gln Glu Ser Ile Arg Gln Trp Lys Leu Lys 
                485                 490                 495     


His Lys Lys Leu Glu Arg Ala Leu Glu Lys Gln Ser Glu Thr Val Asp 
            500                 505                 510         


Glu Leu Thr Gly Lys Asn Asn Gln Ile Leu Lys Glu Lys Asp Glu Leu 
        515                 520                 525             


Lys Thr Gln Leu Tyr Ala Ala Leu Gln Gln Ile Glu Asn Leu Arg Lys 
    530                 535                 540                 


Glu Leu Asn Asp Val Leu Thr Lys Arg Ala Leu Gln Glu Glu Glu Leu 
545                 550                 555                 560 


His Ser Lys Glu Glu Lys Leu Arg Asp Ile Lys Ser His Gln Ala Asp 
                565                 570                 575     


Leu Glu Leu Glu Val Lys Asn Ser Leu Asp Thr Ile His Arg Leu Glu 
            580                 585                 590         


Ser Glu Leu Lys Lys Gln Ser Lys Ile Gln Ser Gln Met Lys Val Glu 
        595                 600                 605             


Lys Ala His Leu Glu Glu Glu Ile Ala Glu Leu Lys Lys Ser Gln Ala 
    610                 615                 620                 


Gln Asp Lys Ala Lys Leu Leu Glu Met Gln Glu Ser Ile Lys Asp Leu 
625                 630                 635                 640 


Ser Ala Ile Arg Ala Asp Leu Ala Asn Lys Leu Ala Glu Glu Glu Arg 
                645                 650                 655     


Ala Lys Lys Ala Val Leu Lys Asp Leu Ser Asp Leu Thr Ala Gln Ala 
            660                 665                 670         


Lys Ser Arg Asp Glu Glu Thr Ala Thr Ile Ile Thr Gln Leu Lys Leu 
        675                 680                 685             


Glu Arg Asp Val His Gln Arg Glu Leu Lys Asp Leu Thr Ser Ser Leu 
    690                 695                 700                 


Gln Ser Val Lys Thr Lys His Glu Gln Asn Ile Gln Glu Leu Met Lys 
705                 710                 715                 720 


His Phe Lys Lys Glu Lys Ser Glu Ala Glu Asn His Ile Arg Thr Leu 
                725                 730                 735     


Lys Ala Glu Ser Leu Glu Glu Lys Asn Met Ala Lys Ile His Arg Gly 
            740                 745                 750         


Gln Leu Glu Lys Leu Lys Ser Gln Cys Asp Arg Leu Thr Glu Glu Leu 
        755                 760                 765             


Thr Gln Asn Glu Asn Glu Asn Lys Lys Leu Lys Leu Lys Tyr Gln Cys 
    770                 775                 780                 


Leu Lys Asp Gln Leu Glu Glu Arg Glu Lys His Ile Ser Ile Glu Glu 
785                 790                 795                 800 


Glu His Leu Arg Arg Met Glu Glu Ala Arg Leu Gln Leu Lys Asp Gln 
                805                 810                 815     


Leu Leu Cys Leu Glu Thr Glu Gln Glu Ser Ile Leu Gly Val Ile Gly 
            820                 825                 830         


Lys Glu Ile Asp Ala Ala Cys Lys Thr Phe Ser Lys Asp Ser Val Glu 
        835                 840                 845             


Lys Leu Lys Val Phe Ser Ser Gly Pro Asp Ile His Tyr Asp Pro His 
    850                 855                 860                 


Arg Trp Leu Ala Glu Ser Lys Thr Lys Leu Gln Trp Leu Cys Glu Glu 
865                 870                 875                 880 


Leu Lys Glu Arg Glu Asn Arg Glu Lys Asn Leu Arg His Gln Leu Met 
                885                 890                 895     


Leu Cys Arg Gln Gln Leu Arg Asn Leu Thr Glu Asn Lys Glu Ser Glu 
            900                 905                 910         


Leu Gln Cys Leu Phe Gln Gln Ile Glu Arg Gln Glu Gln Leu Leu Asp 
        915                 920                 925             


Glu Ile His Arg Glu Lys Arg Asp Leu Leu Glu Glu Thr Gln Arg Lys 
    930                 935                 940                 


Asp Glu Glu Met Gly Ser Leu Gln Asp Arg Val Ile Ala Leu Glu Thr 
945                 950                 955                 960 


Ser Thr Gln Val Ala Leu Asp His Leu Glu Ser Val Pro Glu Lys Leu 
                965                 970                 975     


Ser Leu Leu Glu Asp Phe Lys Asp Phe Arg Arg 
            980                 985         


<210> 6826
<211> 1718
<212> PRT
<213> Homo sapiens

<400> 6826
Met Ser Gly Thr Ser Ser Pro Glu Ala Val Lys Lys Leu Leu Glu Asn 
1               5                   10                  15      


Met Gln Ser Asp Leu Arg Ala Leu Ser Leu Glu Cys Lys Lys Lys Phe 
            20                  25                  30          


Pro Pro Val Lys Glu Ala Ala Glu Ser Gly Ile Ile Lys Val Lys Thr 
        35                  40                  45              


Ile Ala Ala Arg Asn Thr Glu Ile Leu Ala Ala Leu Lys Glu Asn Ser 
    50                  55                  60                  


Ser Glu Val Val Gln Pro Phe Leu Met Gly Cys Gly Thr Lys Glu Pro 
65                  70                  75                  80  


Lys Ile Thr Gln Leu Cys Leu Ala Ala Ile Gln Arg Leu Met Ser His 
                85                  90                  95      


Glu Val Val Ser Glu Thr Ala Ala Gly Asn Ile Ile Asn Met Leu Trp 
            100                 105                 110         


Gln Leu Met Glu Asn Ser Leu Glu Glu Leu Lys Leu Leu Gln Thr Val 
        115                 120                 125             


Leu Val Leu Leu Thr Thr Asn Thr Val Val His Asp Glu Ala Leu Ser 
    130                 135                 140                 


Lys Ala Ile Val Leu Cys Phe Arg Leu His Phe Thr Lys Asp Asn Ile 
145                 150                 155                 160 


Thr Asn Asn Thr Ala Ala Ala Thr Val Arg Gln Val Val Thr Val Val 
                165                 170                 175     


Phe Glu Arg Met Val Ala Glu Asp Glu Arg His Arg Asp Ile Ile Glu 
            180                 185                 190         


Gln Pro Val Leu Val Gln Gly Asn Ser Asn Arg Arg Ser Val Ser Thr 
        195                 200                 205             


Leu Lys Pro Cys Ala Lys Asp Ala Tyr Met Leu Phe Gln Asp Leu Cys 
    210                 215                 220                 


Gln Leu Val Asn Ala Asp Ala Pro Tyr Trp Leu Val Gly Met Thr Glu 
225                 230                 235                 240 


Met Thr Arg Thr Phe Gly Leu Glu Leu Leu Glu Ser Val Leu Asn Asp 
                245                 250                 255     


Phe Pro Gln Val Phe Leu Gln His Gln Glu Phe Ser Phe Leu Leu Lys 
            260                 265                 270         


Glu Arg Val Cys Pro Leu Val Ile Lys Leu Phe Ser Pro Asn Ile Lys 
        275                 280                 285             


Phe Arg Gln Gly Ser Ser Thr Ser Ser Ser Pro Ala Pro Val Glu Lys 
    290                 295                 300                 


Pro Tyr Phe Pro Ile Cys Met Arg Leu Leu Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Ile Lys Gln Phe Tyr Ser Leu Leu Val Thr Glu Cys Glu Ile Phe Leu 
                325                 330                 335     


Ser Leu Leu Val Lys Phe Leu Asp Ala Asp Lys Pro Gln Trp Leu Arg 
            340                 345                 350         


Ala Val Ala Val Glu Ser Ile His Arg Phe Cys Val Gln Pro Gln Leu 
        355                 360                 365             


Leu Arg Ser Phe Cys Gln Ser Tyr Asp Met Lys Gln His Ser Thr Lys 
    370                 375                 380                 


Val Phe Arg Asp Ile Val Asn Ala Leu Gly Ser Phe Ile Gln Ser Leu 
385                 390                 395                 400 


Phe Leu Val Pro Pro Thr Gly Asn Pro Ala Thr Ser Asn Gln Ala Gly 
                405                 410                 415     


Asn Asn Asn Leu Gly Gly Ser Val Ser Ala Pro Ala Asn Ser Gly Met 
            420                 425                 430         


Val Gly Ile Gly Gly Gly Val Thr Leu Leu Pro Ala Phe Glu Tyr Arg 
        435                 440                 445             


Gly Thr Trp Ile Pro Ile Leu Thr Ile Thr Val Gln Gly Ser Ala Lys 
    450                 455                 460                 


Ala Thr Tyr Leu Glu Met Leu Asp Lys Val Glu Pro Pro Thr Ile Pro 
465                 470                 475                 480 


Glu Gly Tyr Ala Met Ser Val Ala Phe His Cys Leu Leu Asp Leu Val 
                485                 490                 495     


Arg Gly Ile Thr Ser Met Ile Glu Gly Glu Leu Gly Glu Leu Glu Thr 
            500                 505                 510         


Glu Cys Gln Thr Thr Thr Glu Glu Gly Ser Ser Pro Thr Gln Ser Thr 
        515                 520                 525             


Glu Gln Gln Asp Leu Gln Ser Thr Ser Asp Gln Met Asp Lys Glu Ile 
    530                 535                 540                 


Val Ser Arg Ala Val Trp Glu Glu Met Val Asn Ala Cys Trp Cys Gly 
545                 550                 555                 560 


Leu Leu Ala Ala Leu Ser Leu Leu Leu Asp Ala Ser Thr Asp Glu Ala 
                565                 570                 575     


Ala Thr Glu Asn Ile Leu Lys Ala Glu Leu Thr Met Ala Ala Leu Cys 
            580                 585                 590         


Gly Arg Leu Gly Leu Val Thr Ser Arg Asp Ala Phe Ile Thr Ala Ile 
        595                 600                 605             


Cys Lys Gly Ser Leu Pro Pro His Tyr Ala Leu Thr Val Leu Asn Thr 
    610                 615                 620                 


Thr Thr Ala Ala Thr Leu Ser Asn Lys Ser Tyr Ser Val Gln Gly Gln 
625                 630                 635                 640 


Ser Val Met Met Ile Ser Pro Ser Ser Glu Ser His Gln Gln Val Val 
                645                 650                 655     


Ala Val Gly Gln Pro Leu Ala Val Gln Pro Gln Gly Thr Val Met Leu 
            660                 665                 670         


Thr Ser Lys Asn Ile Gln Cys Met Arg Thr Leu Leu Asn Leu Ala His 
        675                 680                 685             


Cys His Gly Ala Val Leu Gly Thr Ser Trp Gln Leu Val Leu Ala Thr 
    690                 695                 700                 


Leu Gln His Leu Val Trp Ile Leu Gly Leu Lys Pro Ser Ser Gly Gly 
705                 710                 715                 720 


Ala Leu Lys Pro Gly Arg Ala Val Glu Gly Pro Ser Thr Val Leu Thr 
                725                 730                 735     


Thr Ala Val Met Thr Asp Leu Pro Val Ile Ser Asn Ile Leu Ser Arg 
            740                 745                 750         


Leu Phe Glu Ser Ser Gln Tyr Leu Asp Asp Val Ser Leu His His Leu 
        755                 760                 765             


Ile Asn Ala Leu Cys Ser Leu Ser Leu Glu Ala Met Asp Met Ala Tyr 
    770                 775                 780                 


Gly Asn Asn Lys Glu Pro Ser Leu Phe Ala Val Ala Lys Leu Leu Glu 
785                 790                 795                 800 


Thr Gly Leu Val Asn Met His Arg Ile Glu Ile Leu Trp Arg Pro Leu 
                805                 810                 815     


Thr Gly His Leu Leu Glu Lys Val Cys Gln His Pro Asn Ser Arg Met 
            820                 825                 830         


Arg Glu Trp Gly Ala Glu Ala Leu Thr Ser Leu Ile Lys Ala Gly Leu 
        835                 840                 845             


Thr Phe Asn His Asp Pro Pro Leu Ser Gln Asn Gln Arg Leu Gln Leu 
    850                 855                 860                 


Leu Leu Leu Asn Pro Leu Lys Glu Met Ser Asn Ile Asn His Pro Asp 
865                 870                 875                 880 


Ile Arg Leu Lys Gln Leu Glu Cys Val Leu Gln Ile Leu Gln Ser Gln 
                885                 890                 895     


Gly Asp Ser Leu Gly Pro Gly Trp Pro Leu Val Leu Gly Val Met Gly 
            900                 905                 910         


Ala Ile Arg Asn Asp Gln Gly Glu Ser Leu Ile Arg Thr Ala Phe Gln 
        915                 920                 925             


Cys Leu Gln Leu Val Val Thr Asp Phe Leu Pro Thr Met Pro Cys Thr 
    930                 935                 940                 


Cys Leu Gln Ile Val Val Asp Val Ala Gly Ser Phe Gly Leu His Asn 
945                 950                 955                 960 


Gln Glu Leu Asn Ile Ser Leu Thr Ser Ile Gly Leu Leu Trp Asn Ile 
                965                 970                 975     


Ser Asp Tyr Phe Phe Gln Arg Gly Glu Thr Ile Glu Lys Glu Leu Asn 
            980                 985                 990         


Lys Glu Glu Ala Ala Gln Gln Lys  Gln Ala Glu Glu Lys  Gly Val Val 
        995                 1000                 1005             


Leu Asn  Arg Pro Phe His Pro  Ala Pro Pro Phe Asp  Cys Leu Trp 
    1010                 1015                 1020             


Leu Cys  Leu Tyr Ala Lys Leu  Gly Glu Leu Cys Val  Asp Pro Arg 
    1025                 1030                 1035             


Pro Ala  Val Arg Lys Ser Ala  Gly Gln Thr Leu Phe  Ser Thr Ile 
    1040                 1045                 1050             


Gly Ala  His Gly Thr Leu Leu  Gln His Ser Thr Trp  His Thr Val 
    1055                 1060                 1065             


Ile Trp  Lys Val Leu Phe His  Leu Leu Asp Arg Val  Arg Glu Ser 
    1070                 1075                 1080             


Ser Thr  Thr Ala Asp Lys Glu  Lys Ile Glu Ser Gly  Gly Gly Asn 
    1085                 1090                 1095             


Ile Leu  Ile His His Ser Arg  Asp Thr Ala Glu Lys  Gln Trp Ala 
    1100                 1105                 1110             


Glu Thr  Trp Val Leu Thr Leu  Ala Gly Val Ala Arg  Ile Phe Asn 
    1115                 1120                 1125             


Thr Arg  Arg Tyr Leu Leu Gln  Pro Leu Gly Asp Phe  Ser Arg Ala 
    1130                 1135                 1140             


Trp Asp  Val Leu Leu Asp His  Ile Gln Ser Ala Ala  Leu Ser Lys 
    1145                 1150                 1155             


Asn Asn  Glu Val Ser Leu Ala  Ala Leu Lys Ser Phe  Gln Glu Ile 
    1160                 1165                 1170             


Leu Gln  Ile Val Ser Pro Val  Arg Asp Ser Asp Lys  Pro Glu Thr 
    1175                 1180                 1185             


Pro Pro  Val Val Asn Val Pro  Val Pro Val Leu Ile  Gly Pro Ile 
    1190                 1195                 1200             


Ser Gly  Met Ser Arg Pro Phe  Val Arg Thr Asp Ser  Ile Gly Glu 
    1205                 1210                 1215             


Lys Leu  Gly Arg Tyr Ser Ser  Ser Glu Pro Pro Ile  Val Thr Asp 
    1220                 1225                 1230             


Glu Leu  Glu Asp Leu Asn Leu  Trp Trp Ala Ala Trp  Asn Thr Trp 
    1235                 1240                 1245             


Tyr Arg  Ile Gly Ser Glu Ser  Thr Lys Pro Pro Ile  Thr Phe Asp 
    1250                 1255                 1260             


Lys Leu  Thr Phe Ile Pro Ser  Gln Pro Phe Leu Thr  Ala Leu Ile 
    1265                 1270                 1275             


Gln Ile  Phe Pro Ala Leu Tyr  Gln His Ile Lys Thr  Gly Phe Asn 
    1280                 1285                 1290             


Met Asp  Asp Leu Gln Lys Leu  Gly Val Ile Leu His  Ser Ala Ile 
    1295                 1300                 1305             


Ser Val  Pro Ile Ser Ser Asp  Ala Ser Pro Phe Ile  Leu Pro Ser 
    1310                 1315                 1320             


Tyr Thr  Glu Ala Val Leu Thr  Ser Leu Gln Glu Ala  Val Leu Thr 
    1325                 1330                 1335             


Ala Leu  Asp Val Leu Gln Lys  Ala Ile Cys Val Gly  Pro Glu Asn 
    1340                 1345                 1350             


Met Gln  Ile Met Tyr Pro Ala  Ile Phe Asp Gln Leu  Leu Ala Phe 
    1355                 1360                 1365             


Val Glu  Phe Ser Cys Lys Pro  Pro Gln Tyr Gly Gln  Leu Glu Thr 
    1370                 1375                 1380             


Lys His  Ile Ala Asn Ala Lys  Tyr Asn Gln Ile Gln  Leu Phe Ala 
    1385                 1390                 1395             


Pro Ala  Glu Trp Val Ala Leu  Asn Tyr Val Pro Phe  Ala Glu Arg 
    1400                 1405                 1410             


Ser Leu  Glu Val Val Val Asp  Leu Tyr Gln Lys Thr  Ala Cys His 
    1415                 1420                 1425             


Lys Ala  Val Val Asn Glu Lys  Val Leu Gln Asn Ile  Ile Lys Thr 
    1430                 1435                 1440             


Leu Arg  Val Pro Leu Ser Leu  Lys Tyr Ser Cys Pro  Ser Glu Ser 
    1445                 1450                 1455             


Thr Trp  Lys Leu Ala Val Ser  Ser Leu Leu Arg Val  Leu Ser Ile 
    1460                 1465                 1470             


Gly Leu  Pro Val Ala Arg Gln  His Ala Ser Ser Gly  Lys Phe Asp 
    1475                 1480                 1485             


Ser Met  Trp Pro Glu Leu Ala  Asn Thr Phe Glu Asp  Phe Leu Phe 
    1490                 1495                 1500             


Thr Lys  Ser Ile Pro Pro Asp  Asn Leu Ser Ile Gln  Glu Phe Gln 
    1505                 1510                 1515             


Arg Asn  Glu Asn Ile Asp Val  Glu Val Val Gln Leu  Ile Ser Asn 
    1520                 1525                 1530             


Glu Ile  Leu Pro Tyr Ala Asn  Phe Ile Pro Lys Glu  Phe Val Gly 
    1535                 1540                 1545             


Gln Ile  Met Thr Met Leu Asn  Lys Gly Ser Ile His  Ser Gln Ser 
    1550                 1555                 1560             


Ser Ser  Phe Thr Glu Ala Glu  Ile Asp Ile Arg Leu  Arg Glu Glu 
    1565                 1570                 1575             


Phe Ser  Lys Met Cys Phe Glu  Thr Leu Leu Gln Phe  Ser Phe Ser 
    1580                 1585                 1590             


Asn Lys  Val Thr Thr Pro Gln  Glu Gly Tyr Ile Ser  Arg Met Ala 
    1595                 1600                 1605             


Leu Ser  Val Leu Leu Lys Arg  Ser Gln Asp Val Leu  His Arg Tyr 
    1610                 1615                 1620             


Ile Glu  Asp Glu Arg Leu Ser  Gly Lys Cys Pro Leu  Pro Arg Gln 
    1625                 1630                 1635             


Gln Val  Thr Glu Ile Ile Phe  Val Leu Lys Ala Val  Ser Thr Leu 
    1640                 1645                 1650             


Ile Asp  Ser Leu Lys Lys Thr  Gln Pro Glu Asn Val  Asp Gly Asn 
    1655                 1660                 1665             


Thr Trp  Ala Gln Val Ile Ala  Leu Tyr Pro Thr Leu  Val Glu Cys 
    1670                 1675                 1680             


Ile Thr  Cys Ser Ser Ser Glu  Val Cys Ser Ala Leu  Lys Glu Ala 
    1685                 1690                 1695             


Leu Val  Pro Phe Lys Asp Phe  Met Gln Pro Pro Ala  Ser Arg Val 
    1700                 1705                 1710             


Gln Asn  Gly Glu Ser 
    1715             


<210> 6827
<211> 699
<212> PRT
<213> Homo sapiens

<400> 6827
Met Ser Ser Arg Lys Val Leu Ala Ile Gln Ala Arg Lys Arg Arg Pro 
1               5                   10                  15      


Lys Arg Glu Lys His Pro Lys Lys Pro Glu Pro Gln Gln Lys Ala Pro 
            20                  25                  30          


Leu Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu 
        35                  40                  45              


Pro Asp Pro Thr Pro Pro Glu Pro Glu Glu Glu Ile Leu Gly Ser Asp 
    50                  55                  60                  


Asp Glu Glu Gln Glu Asp Pro Ala Asp Tyr Cys Lys Gly Gly Tyr His 
65                  70                  75                  80  


Pro Val Lys Ile Gly Asp Leu Phe Asn Gly Arg Tyr His Val Ile Arg 
                85                  90                  95      


Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu Cys Trp Asp Met 
            100                 105                 110         


Gln Gly Lys Arg Phe Val Ala Met Lys Val Val Lys Ser Ala Gln His 
        115                 120                 125             


Tyr Thr Glu Thr Ala Leu Asp Glu Ile Lys Leu Leu Lys Cys Val Arg 
    130                 135                 140                 


Glu Ser Asp Pro Ser Asp Pro Asn Lys Asp Met Val Val Gln Leu Ile 
145                 150                 155                 160 


Asp Asp Phe Lys Ile Ser Gly Met Asn Gly Ile His Val Cys Met Val 
                165                 170                 175     


Phe Glu Val Leu Gly His His Leu Leu Lys Trp Ile Ile Lys Ser Asn 
            180                 185                 190         


Tyr Gln Gly Leu Pro Val Arg Cys Val Lys Ser Ile Ile Arg Gln Val 
        195                 200                 205             


Leu Gln Gly Leu Asp Tyr Leu His Ser Lys Cys Lys Ile Ile His Thr 
    210                 215                 220                 


Asp Ile Lys Pro Glu Asn Ile Leu Met Cys Val Asp Asp Ala Tyr Val 
225                 230                 235                 240 


Arg Arg Met Ala Ala Glu Ala Thr Glu Trp Gln Lys Ala Gly Ala Pro 
                245                 250                 255     


Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro Gln Gln Lys Pro Ile 
            260                 265                 270         


Gly Lys Ile Ser Lys Asn Lys Lys Lys Lys Leu Lys Lys Lys Gln Lys 
        275                 280                 285             


Arg Gln Ala Glu Leu Leu Glu Lys Arg Leu Gln Glu Ile Glu Glu Leu 
    290                 295                 300                 


Glu Arg Glu Ala Glu Arg Lys Ile Ile Glu Glu Asn Ile Thr Ser Ala 
305                 310                 315                 320 


Ala Pro Ser Asn Asp Gln Asp Gly Glu Tyr Cys Pro Glu Val Lys Leu 
                325                 330                 335     


Lys Thr Thr Gly Leu Glu Glu Ala Ala Glu Ala Glu Thr Ala Lys Asp 
            340                 345                 350         


Asn Gly Glu Ala Glu Asp Gln Glu Glu Lys Glu Asp Ala Glu Lys Glu 
        355                 360                 365             


Asn Ile Glu Lys Asp Glu Asp Asp Val Asp Gln Glu Leu Ala Asn Ile 
    370                 375                 380                 


Asp Pro Thr Trp Ile Glu Ser Pro Lys Thr Asn Gly His Ile Glu Asn 
385                 390                 395                 400 


Gly Pro Phe Ser Leu Glu Gln Gln Leu Asp Asp Glu Asp Asp Asp Glu 
                405                 410                 415     


Glu Asp Cys Pro Asn Pro Glu Glu Tyr Asn Leu Asp Glu Pro Asn Ala 
            420                 425                 430         


Glu Ser Asp Tyr Thr Tyr Ser Ser Ser Tyr Glu Gln Phe Asn Gly Glu 
        435                 440                 445             


Leu Pro Asn Gly Arg His Lys Ile Pro Glu Ser Gln Phe Pro Glu Phe 
    450                 455                 460                 


Ser Thr Ser Leu Phe Ser Gly Ser Leu Glu Pro Val Ala Cys Gly Ser 
465                 470                 475                 480 


Val Leu Ser Glu Gly Ser Pro Leu Thr Glu Gln Glu Glu Ser Ser Pro 
                485                 490                 495     


Ser His Asp Arg Ser Arg Thr Val Ser Ala Ser Ser Thr Gly Asp Leu 
            500                 505                 510         


Pro Lys Ala Lys Thr Arg Ala Ala Asp Leu Leu Val Asn Pro Leu Asp 
        515                 520                 525             


Pro Arg Asn Ala Asp Lys Ile Arg Val Lys Ile Ala Asp Leu Gly Asn 
    530                 535                 540                 


Ala Cys Trp Val His Lys His Phe Thr Glu Asp Ile Gln Thr Arg Gln 
545                 550                 555                 560 


Tyr Arg Ser Ile Glu Val Leu Ile Gly Ala Gly Tyr Ser Thr Pro Ala 
                565                 570                 575     


Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu Leu Ala Thr Gly Asp 
            580                 585                 590         


Tyr Leu Phe Glu Pro His Ser Gly Glu Asp Tyr Ser Arg Asp Glu Asp 
        595                 600                 605             


His Ile Ala His Ile Ile Glu Leu Leu Gly Ser Ile Pro Arg His Phe 
    610                 615                 620                 


Ala Leu Ser Gly Lys Tyr Ser Arg Glu Phe Phe Asn Arg Arg Gly Glu 
625                 630                 635                 640 


Leu Arg His Ile Thr Lys Leu Lys Pro Trp Ser Leu Phe Asp Val Leu 
                645                 650                 655     


Val Glu Lys Tyr Gly Trp Pro His Glu Asp Ala Ala Gln Phe Thr Asp 
            660                 665                 670         


Phe Leu Ile Pro Met Leu Glu Met Val Pro Glu Lys Arg Ala Ser Ala 
        675                 680                 685             


Gly Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
    690                 695                 


<210> 6828
<211> 370
<212> PRT
<213> Homo sapiens

<400> 6828
Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Asn Ala Leu Pro Leu 
1               5                   10                  15      


Met Leu Ala Glu Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly 
            20                  25                  30          


Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Gln Val Glu 
        35                  40                  45              


Pro Ala Asn Lys Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr Tyr Glu 
    50                  55                  60                  


Leu Ala Leu Gln Thr Gly Lys Val Ile Glu Gln Met Gly Lys Phe Tyr 
65                  70                  75                  80  


Pro Glu Leu Lys Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu Glu Arg 
                85                  90                  95      


Gly Gln Lys Ile Ser Glu Gln Ile Val Ile Gly Thr Pro Gly Thr Val 
            100                 105                 110         


Leu Asp Trp Cys Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys Ile Lys 
        115                 120                 125             


Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Ala Thr Gln Gly His 
    130                 135                 140                 


Gln Asp Gln Ser Ile Arg Ile Gln Arg Met Leu Pro Arg Asn Cys Gln 
145                 150                 155                 160 


Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Lys Phe Ala 
                165                 170                 175     


Gln Lys Val Val Pro Asp Pro Asn Val Ile Lys Leu Lys Arg Glu Glu 
            180                 185                 190         


Glu Thr Leu Asp Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser Ser Arg 
        195                 200                 205             


Asp Glu Lys Phe Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile Thr Ile 
    210                 215                 220                 


Ala Gln Ala Met Ile Phe Cys His Thr Arg Lys Thr Ala Ser Trp Leu 
225                 230                 235                 240 


Ala Ala Glu Leu Ser Lys Glu Gly His Gln Val Ala Leu Leu Ser Gly 
                245                 250                 255     


Glu Met Met Val Glu Gln Arg Ala Ala Val Ile Glu Arg Phe Arg Glu 
            260                 265                 270         


Gly Lys Glu Lys Val Leu Val Thr Thr Asn Val Cys Ala Arg Gly Ile 
        275                 280                 285             


Asp Val Glu Gln Val Ser Val Val Ile Asn Phe Asp Leu Pro Val Asp 
    290                 295                 300                 


Lys Asp Gly Asn Pro Asp Asn Glu Thr Tyr Leu His Arg Ile Gly Arg 
305                 310                 315                 320 


Thr Gly Arg Phe Gly Lys Arg Gly Leu Ala Val Asn Met Val Asp Ser 
                325                 330                 335     


Lys His Ser Met Asn Ile Leu Asn Arg Ile Gln Glu His Phe Asn Lys 
            340                 345                 350         


Lys Ile Glu Arg Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu Lys Ile 
        355                 360                 365             


Ala Asn 
    370 


<210> 6829
<211> 879
<212> PRT
<213> Homo sapiens

<400> 6829
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn Glu Glu Lys Ile Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Ile Val His Pro Ser Gln Glu Glu Asp Arg His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val Arg Leu Ser Arg Asp 
    210                 215                 220                 


Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro Asp Pro Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Ile Ile Glu Gln Leu Leu Ser Asn Ile Phe 
                245                 250                 255     


His Lys Glu Lys Asn Glu Ser Ala Ile Val Ser Ala Ile Gln Ile Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His Ile Glu 
        275                 280                 285             


Ile Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn Lys Ser 
    290                 295                 300                 


Val Leu Glu Ala Ile Arg Gly Arg Leu Gly Ser Phe His Glu Leu Leu 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Lys Ser Val Met Lys Thr Thr Trp Gly Val Leu 
                325                 330                 335     


Asp Pro Pro Val Gly Asn Thr Arg Leu Asn Val Ile Arg Leu Ile Ser 
            340                 345                 350         


Ser Leu Leu Gln Thr Asn Thr Ser Ser Ile Asn Gly Asp Leu Met Glu 
        355                 360                 365             


Leu Asn Ser Ile Gly Val Ile Leu Asn Met Phe Phe Lys Tyr Thr Trp 
    370                 375                 380                 


Asn Asn Phe Leu His Thr Gln Val Glu Ile Cys Ile Ala Leu Ile Leu 
385                 390                 395                 400 


Ala Ser Pro Phe Glu Asn Thr Glu Asn Ala Thr Ile Thr Asp Gln Asp 
                405                 410                 415     


Ser Thr Gly Asp Asn Leu Leu Leu Lys His Leu Phe Gln Lys Cys Gln 
            420                 425                 430         


Leu Ile Glu Arg Ile Leu Glu Ala Trp Glu Met Asn Glu Lys Lys Gln 
        435                 440                 445             


Ala Glu Gly Gly Arg Arg His Gly Tyr Met Gly His Leu Thr Arg Ile 
    450                 455                 460                 


Ala Asn Cys Ile Val His Ser Thr Asp Lys Gly Pro Asn Ser Ala Leu 
465                 470                 475                 480 


Val Gln Gln Leu Ile Lys Asp Leu Pro Asp Glu Val Arg Glu Arg Trp 
                485                 490                 495     


Glu Thr Phe Cys Thr Ser Ser Leu Gly Glu Thr Asn Lys Arg Asn Thr 
            500                 505                 510         


Val Asp Leu Val Thr Thr Cys His Ile His Ser Ser Ser Asp Asp Glu 
        515                 520                 525             


Ile Asp Phe Lys Glu Thr Gly Phe Ser Gln Asp Ser Ser Leu Gln Gln 
    530                 535                 540                 


Ala Phe Ser Asp Tyr Gln Met Gln Gln Met Thr Ser Asn Phe Ile Asp 
545                 550                 555                 560 


Gln Phe Gly Phe Asn Asp Glu Lys Phe Ala Asp Gln Asp Asp Ile Gly 
                565                 570                 575     


Asn Val Ser Phe Asp Arg Val Ser Asp Ile Asn Phe Thr Leu Asn Thr 
            580                 585                 590         


Asn Glu Ser Gly Asn Ile Ala Leu Phe Glu Ala Cys Cys Lys Glu Arg 
        595                 600                 605             


Ile Gln Gln Phe Asp Asp Gly Gly Ser Asp Glu Glu Asp Ile Trp Glu 
    610                 615                 620                 


Glu Lys His Ile Ala Phe Thr Pro Glu Ser Gln Arg Arg Ser Ser Ser 
625                 630                 635                 640 


Gly Ser Thr Asp Ser Glu Glu Ser Thr Asp Ser Glu Glu Glu Asp Gly 
                645                 650                 655     


Ala Lys Gln Asp Leu Phe Glu Pro Ser Ser Ala Asn Thr Glu Asp Lys 
            660                 665                 670         


Met Glu Val Asp Leu Ser Glu Pro Pro Asn Trp Ser Ala Asn Phe Asp 
        675                 680                 685             


Val Pro Met Glu Thr Thr His Gly Ala Pro Leu Asp Ser Val Gly Ser 
    690                 695                 700                 


Asp Val Trp Ser Thr Glu Glu Pro Met Pro Thr Lys Glu Thr Gly Trp 
705                 710                 715                 720 


Ala Ser Phe Ser Glu Phe Thr Ser Ser Leu Ser Thr Lys Asp Ser Leu 
                725                 730                 735     


Arg Ser Asn Ser Pro Val Glu Met Glu Thr Ser Thr Glu Pro Met Asp 
            740                 745                 750         


Pro Leu Thr Pro Ser Ala Ala Ala Leu Ala Val Gln Pro Glu Ala Ala 
        755                 760                 765             


Gly Ser Val Ala Met Glu Ala Ser Ser Asp Gly Glu Glu Asp Ala Glu 
    770                 775                 780                 


Ser Thr Asp Lys Val Thr Glu Thr Val Met Asn Gly Gly Met Lys Glu 
785                 790                 795                 800 


Thr Leu Ser Leu Thr Val Asp Ala Lys Thr Glu Thr Ala Val Phe Lys 
                805                 810                 815     


Arg Leu Leu Gly Gly Cys Ser Glu Glu Gly Lys Leu Ser Thr Ser Gln 
            820                 825                 830         


Asp Ala Ala Cys Lys Asp Ala Glu Glu Cys Pro Glu Thr Ala Glu Ala 
        835                 840                 845             


Lys Cys Ala Ala Pro Arg Pro Pro Ser Ser Ser Pro Glu Gln Arg Thr 
    850                 855                 860                 


Gly Gln Pro Ser Ala Pro Gly Asp Thr Ser Val Asn Gly Pro Val 
865                 870                 875                 


<210> 6830
<211> 873
<212> PRT
<213> Homo sapiens

<400> 6830
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn Glu Glu Lys Ile Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Ile Val His Pro Ser Gln Glu Glu Asp Arg His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val Arg Leu Ser Arg Asp 
    210                 215                 220                 


Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro Asp Pro Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Ile Ile Glu Gln Leu Leu Ser Asn Ile Phe 
                245                 250                 255     


His Lys Glu Lys Asn Glu Ser Ala Ile Val Ser Ala Ile Gln Ile Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His Ile Glu 
        275                 280                 285             


Ile Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn Lys Ser 
    290                 295                 300                 


Val Leu Glu Ala Ile Arg Gly Arg Leu Gly Ser Phe His Glu Leu Leu 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Lys Ser Val Met Lys Thr Thr Trp Gly Val Leu 
                325                 330                 335     


Asp Pro Pro Val Gly Asn Thr Arg Leu Asn Val Ile Arg Leu Ile Ser 
            340                 345                 350         


Ser Leu Leu Gln Thr Asn Thr Ser Ser Ile Asn Gly Asp Leu Met Glu 
        355                 360                 365             


Leu Asn Ser Ile Gly Val Ile Leu Asn Met Phe Phe Lys Tyr Thr Trp 
    370                 375                 380                 


Asn Asn Phe Leu His Thr Gln Val Glu Ile Cys Ile Ala Leu Ile Leu 
385                 390                 395                 400 


Ala Ser Pro Phe Glu Asn Thr Glu Asn Ala Thr Ile Thr Asp Gln Asp 
                405                 410                 415     


Ser Thr Gly Asp Asn Leu Leu Leu Lys His Leu Phe Gln Lys Cys Gln 
            420                 425                 430         


Leu Ile Glu Arg Ile Leu Glu Ala Trp Glu Met Asn Glu Lys Lys Gln 
        435                 440                 445             


Ala Glu Gly Gly Arg Arg His Gly Tyr Met Gly His Leu Thr Arg Ile 
    450                 455                 460                 


Ala Asn Cys Ile Val His Ser Thr Asp Lys Gly Pro Asn Ser Ala Leu 
465                 470                 475                 480 


Val Gln Gln Leu Ile Lys Asp Leu Pro Asp Glu Val Arg Glu Arg Trp 
                485                 490                 495     


Glu Thr Phe Cys Thr Ser Ser Leu Gly Glu Thr Asn Lys Arg Asn Thr 
            500                 505                 510         


Val Asp Leu Val Thr Thr Cys His Ile His Ser Ser Ser Asp Asp Glu 
        515                 520                 525             


Ile Asp Phe Lys Glu Thr Gly Phe Ser Gln Asp Ser Ser Leu Gln Gln 
    530                 535                 540                 


Ala Phe Ser Asp Tyr Gln Met Gln Gln Met Thr Ser Asn Phe Ile Asp 
545                 550                 555                 560 


Gln Phe Gly Phe Asn Asp Glu Lys Phe Ala Asp Gln Asp Asp Ile Gly 
                565                 570                 575     


Asn Val Ser Phe Asp Arg Val Ser Asp Ile Asn Phe Thr Leu Asn Thr 
            580                 585                 590         


Asn Glu Ser Gly Asn Ile Ala Leu Phe Glu Ala Cys Cys Lys Glu Arg 
        595                 600                 605             


Ile Gln Gln Phe Asp Asp Gly Gly Ser Asp Glu Glu Asp Ile Trp Glu 
    610                 615                 620                 


Glu Lys His Ile Ala Phe Thr Pro Glu Ser Gln Arg Arg Ser Ser Ser 
625                 630                 635                 640 


Gly Ser Thr Asp Ser Glu Glu Ser Thr Asp Ser Glu Glu Glu Asp Gly 
                645                 650                 655     


Ala Lys Gln Asp Leu Phe Glu Pro Ser Ser Ala Asn Thr Glu Asp Lys 
            660                 665                 670         


Met Glu Val Asp Leu Ser Glu Pro Pro Asn Trp Ser Ala Asn Phe Asp 
        675                 680                 685             


Val Pro Met Glu Thr Thr His Gly Ala Pro Leu Asp Ser Val Gly Ser 
    690                 695                 700                 


Asp Val Trp Ser Thr Glu Glu Pro Met Pro Thr Lys Glu Thr Gly Trp 
705                 710                 715                 720 


Ala Ser Phe Ser Glu Phe Thr Ser Ser Leu Ser Thr Lys Asp Ser Leu 
                725                 730                 735     


Arg Ser Asn Ser Pro Val Glu Met Glu Thr Ser Thr Glu Pro Met Asp 
            740                 745                 750         


Pro Leu Thr Pro Ser Ala Ala Ala Leu Ala Val Gln Pro Glu Ala Ala 
        755                 760                 765             


Gly Ser Val Ala Met Glu Ala Ser Ser Asp Gly Glu Glu Asp Ala Glu 
    770                 775                 780                 


Ser Thr Asp Lys Val Thr Glu Thr Val Met Asn Gly Gly Met Lys Glu 
785                 790                 795                 800 


Thr Leu Ser Leu Thr Val Asp Ala Lys Thr Glu Thr Ala Val Phe Lys 
                805                 810                 815     


Ser Glu Glu Gly Lys Leu Ser Thr Ser Gln Asp Ala Ala Cys Lys Asp 
            820                 825                 830         


Ala Glu Glu Cys Pro Glu Thr Ala Glu Ala Lys Cys Ala Ala Pro Arg 
        835                 840                 845             


Pro Pro Ser Ser Ser Pro Glu Gln Arg Thr Gly Gln Pro Ser Ala Pro 
    850                 855                 860                 


Gly Asp Thr Ser Val Asn Gly Pro Val 
865                 870             


<210> 6831
<211> 879
<212> PRT
<213> Homo sapiens

<400> 6831
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn Glu Glu Lys Ile Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Ile Val His Pro Ser Gln Glu Glu Asp Arg His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val Arg Leu Ser Arg Asp 
    210                 215                 220                 


Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro Asp Pro Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Ile Ile Glu Gln Leu Leu Ser Asn Ile Phe 
                245                 250                 255     


His Lys Glu Lys Asn Glu Ser Ala Ile Val Ser Ala Ile Gln Ile Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His Ile Glu 
        275                 280                 285             


Ile Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn Lys Ser 
    290                 295                 300                 


Val Leu Glu Ala Ile Arg Gly Arg Leu Gly Ser Phe His Glu Leu Leu 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Lys Ser Val Met Lys Thr Thr Trp Gly Val Leu 
                325                 330                 335     


Asp Pro Pro Val Gly Asn Thr Arg Leu Asn Val Ile Arg Leu Ile Ser 
            340                 345                 350         


Ser Leu Leu Gln Thr Asn Thr Ser Ser Ile Asn Gly Asp Leu Met Glu 
        355                 360                 365             


Leu Asn Ser Ile Gly Val Ile Leu Asn Met Phe Phe Lys Tyr Thr Trp 
    370                 375                 380                 


Asn Asn Phe Leu His Thr Gln Val Glu Ile Cys Ile Ala Leu Ile Leu 
385                 390                 395                 400 


Ala Ser Pro Phe Glu Asn Thr Glu Asn Ala Thr Ile Thr Asp Gln Asp 
                405                 410                 415     


Ser Thr Gly Asp Asn Leu Leu Leu Lys His Leu Phe Gln Lys Cys Gln 
            420                 425                 430         


Leu Ile Glu Arg Ile Leu Glu Ala Trp Glu Met Asn Glu Lys Lys Gln 
        435                 440                 445             


Ala Glu Gly Gly Arg Arg His Gly Tyr Met Gly His Leu Thr Arg Ile 
    450                 455                 460                 


Ala Asn Cys Ile Val His Ser Thr Asp Lys Gly Pro Asn Ser Ala Leu 
465                 470                 475                 480 


Val Gln Gln Leu Ile Lys Asp Leu Pro Asp Glu Val Arg Glu Arg Trp 
                485                 490                 495     


Glu Thr Phe Cys Thr Ser Ser Leu Gly Glu Thr Asn Lys Arg Asn Thr 
            500                 505                 510         


Val Asp Leu Val Thr Thr Cys His Ile His Ser Ser Ser Asp Asp Glu 
        515                 520                 525             


Ile Asp Phe Lys Glu Thr Gly Phe Ser Gln Asp Ser Ser Leu Gln Gln 
    530                 535                 540                 


Ala Phe Ser Asp Tyr Gln Met Gln Gln Met Thr Ser Asn Phe Ile Asp 
545                 550                 555                 560 


Gln Phe Gly Phe Asn Asp Glu Lys Phe Ala Asp Gln Asp Asp Ile Gly 
                565                 570                 575     


Asn Val Ser Phe Asp Arg Val Ser Asp Ile Asn Phe Thr Leu Asn Thr 
            580                 585                 590         


Asn Glu Ser Gly Asn Ile Ala Leu Phe Glu Ala Cys Cys Lys Glu Arg 
        595                 600                 605             


Ile Gln Gln Phe Asp Asp Gly Gly Ser Asp Glu Glu Asp Ile Trp Glu 
    610                 615                 620                 


Glu Lys His Ile Ala Phe Thr Pro Glu Ser Gln Arg Arg Ser Ser Ser 
625                 630                 635                 640 


Gly Ser Thr Asp Ser Glu Glu Ser Thr Asp Ser Glu Glu Glu Asp Gly 
                645                 650                 655     


Ala Lys Gln Asp Leu Phe Glu Pro Ser Ser Ala Asn Thr Glu Asp Lys 
            660                 665                 670         


Met Glu Val Asp Leu Ser Glu Pro Pro Asn Trp Ser Ala Asn Phe Asp 
        675                 680                 685             


Val Pro Met Glu Thr Thr His Gly Ala Pro Leu Asp Ser Val Gly Ser 
    690                 695                 700                 


Asp Val Trp Ser Thr Glu Glu Pro Met Pro Thr Lys Glu Thr Gly Trp 
705                 710                 715                 720 


Ala Ser Phe Ser Glu Phe Thr Ser Ser Leu Ser Thr Lys Asp Ser Leu 
                725                 730                 735     


Arg Ser Asn Ser Pro Val Glu Met Glu Thr Ser Thr Glu Pro Met Asp 
            740                 745                 750         


Pro Leu Thr Pro Ser Ala Ala Ala Leu Ala Val Gln Pro Glu Ala Ala 
        755                 760                 765             


Gly Ser Val Ala Met Glu Ala Ser Ser Asp Gly Glu Glu Asp Ala Glu 
    770                 775                 780                 


Ser Thr Asp Lys Val Thr Glu Thr Val Met Asn Gly Gly Met Lys Glu 
785                 790                 795                 800 


Thr Leu Ser Leu Thr Val Asp Ala Lys Thr Glu Thr Ala Val Phe Lys 
                805                 810                 815     


Arg Val Leu Lys Ser Tyr Arg Glu Glu Gly Lys Leu Ser Thr Ser Gln 
            820                 825                 830         


Asp Ala Ala Cys Lys Asp Ala Glu Glu Cys Pro Glu Thr Ala Glu Ala 
        835                 840                 845             


Lys Cys Ala Ala Pro Arg Pro Pro Ser Ser Ser Pro Glu Gln Arg Thr 
    850                 855                 860                 


Gly Gln Pro Ser Ala Pro Gly Asp Thr Ser Val Asn Gly Pro Val 
865                 870                 875                 


<210> 6832
<211> 377
<212> PRT
<213> Homo sapiens

<400> 6832
Met Ser Asp Glu Val Phe Ser Thr Thr Leu Ala Tyr Thr Lys Ser Pro 
1               5                   10                  15      


Lys Val Thr Lys Arg Thr Thr Phe Gln Asp Glu Leu Ile Arg Ala Ile 
            20                  25                  30          


Thr Ala Arg Ser Ala Arg Gln Arg Ser Ser Glu Tyr Ser Asp Asp Phe 
        35                  40                  45              


Asp Ser Asp Glu Ile Val Ser Leu Gly Asp Phe Ser Asp Thr Ser Ala 
    50                  55                  60                  


Asp Glu Asn Ser Val Asn Lys Lys Met Asn Asp Phe His Ile Ser Asp 
65                  70                  75                  80  


Asp Glu Glu Lys Asn Pro Ser Lys Leu Leu Phe Leu Lys Thr Asn Lys 
                85                  90                  95      


Ser Asn Gly Asn Ile Thr Lys Asp Glu Pro Val Cys Ala Ile Lys Asn 
            100                 105                 110         


Glu Glu Glu Met Ala Pro Asp Gly Cys Glu Asp Ile Val Val Lys Ser 
        115                 120                 125             


Phe Ser Glu Ser Gln Asn Lys Asp Glu Glu Phe Glu Lys Asp Lys Ile 
    130                 135                 140                 


Lys Met Lys Pro Lys Pro Arg Ile Leu Ser Ile Lys Ser Thr Ser Ser 
145                 150                 155                 160 


Ala Glu Asn Asn Ser Leu Asp Thr Asp Asp His Phe Lys Pro Ser Pro 
                165                 170                 175     


Arg Pro Arg Ser Met Leu Lys Lys Lys Ser His Met Glu Glu Lys Asp 
            180                 185                 190         


Gly Leu Glu Asp Lys Glu Thr Ala Leu Ser Glu Glu Leu Glu Leu His 
        195                 200                 205             


Ser Ala Pro Ser Ser Leu Pro Thr Pro Asn Gly Ile Gln Leu Glu Ala 
    210                 215                 220                 


Glu Lys Lys Ala Phe Ser Glu Asn Leu Asp Pro Glu Asp Ser Cys Leu 
225                 230                 235                 240 


Thr Ser Leu Ala Ser Ser Ser Leu Lys Gln Ile Leu Gly Asp Ser Phe 
                245                 250                 255     


Ser Pro Gly Ser Glu Gly Asn Ala Ser Gly Lys Asp Pro Asn Glu Glu 
            260                 265                 270         


Ile Thr Glu Asn His Asn Ser Leu Lys Ser Asp Glu Asn Lys Glu Asn 
        275                 280                 285             


Ser Phe Ser Ala Asp His Val Thr Thr Ala Val Glu Lys Ser Lys Glu 
    290                 295                 300                 


Ser Gln Val Thr Ala Asp Asp Leu Glu Glu Glu Lys Ala Lys Ala Glu 
305                 310                 315                 320 


Leu Ile Met Asp Asp Asp Arg Thr Val Asp Pro Leu Leu Ser Lys Ser 
                325                 330                 335     


Gln Ser Ile Leu Ile Ser Thr Ser Ala Thr Ala Ser Ser Lys Lys Thr 
            340                 345                 350         


Ile Glu Asp Arg Asn Ile Lys Asn Lys Lys Ser Thr Asn Asn Arg Ala 
        355                 360                 365             


Ser Ser Ala Ser Ala Ser Lys Ala Ser 
    370                 375         


<210> 6833
<211> 191
<212> PRT
<213> Homo sapiens

<400> 6833
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
65                  70                  75                  80  


Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Thr Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg 
        115                 120                 125             


Arg Val Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Lys Leu Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro 
145                 150                 155                 160 


Phe Val Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala 
                165                 170                 175     


Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
            180                 185                 190     


<210> 6834
<211> 191
<212> PRT
<213> Homo sapiens

<400> 6834
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
65                  70                  75                  80  


Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Thr Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg 
        115                 120                 125             


Arg Val Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Lys Leu Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro 
145                 150                 155                 160 


Phe Val Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala 
                165                 170                 175     


Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
            180                 185                 190     


<210> 6835
<211> 189
<212> PRT
<213> Homo sapiens

<400> 6835
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Ala 
            20                  25                  30          


Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu Thr Asp 
        35                  40                  45              


Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly Leu Arg 
    50                  55                  60                  


Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp Gly Tyr 
65                  70                  75                  80  


Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg Val Glu 
                85                  90                  95      


Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu Val Thr 
            100                 105                 110         


Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg Arg Val 
        115                 120                 125             


Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val Lys Leu 
    130                 135                 140                 


Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro Phe Val 
145                 150                 155                 160 


Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala Phe Pro 
                165                 170                 175     


Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
            180                 185                 


<210> 6836
<211> 191
<212> PRT
<213> Homo sapiens

<400> 6836
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
65                  70                  75                  80  


Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Thr Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg 
        115                 120                 125             


Arg Val Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Lys Leu Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro 
145                 150                 155                 160 


Phe Val Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala 
                165                 170                 175     


Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
            180                 185                 190     


<210> 6837
<211> 334
<212> PRT
<213> Homo sapiens

<400> 6837
Met Ala Glu Glu Val Arg Arg Glu Glu Ala Ser Gly Val Gly Arg Ala 
1               5                   10                  15      


Arg Thr Pro Thr Pro Gly Ala Leu Arg Ala Pro Gln Leu Val Thr Glu 
            20                  25                  30          


Ala Pro Pro Leu His Pro Gly His Thr Leu Met Lys Ala Thr Val Leu 
        35                  40                  45              


Met Arg Gln Pro Gly Arg Val Gln Glu Ile Val Gly Ala Leu Arg Lys 
    50                  55                  60                  


Gly Gly Gly Asp Arg Leu Gln Val Ile Ser Asp Phe Asp Met Thr Leu 
65                  70                  75                  80  


Ser Arg Phe Ala Tyr Asn Gly Lys Arg Cys Pro Ser Ser Tyr Asn Ile 
                85                  90                  95      


Leu Asp Asn Ser Lys Ile Ile Ser Glu Glu Cys Arg Lys Glu Leu Thr 
            100                 105                 110         


Ala Leu Leu His His Tyr Tyr Pro Ile Glu Ile Asp Pro His Arg Thr 
        115                 120                 125             


Val Lys Glu Lys Leu Pro His Met Val Glu Trp Trp Thr Lys Ala His 
    130                 135                 140                 


Asn Leu Leu Cys Gln Gln Lys Ile Gln Lys Phe Gln Ile Ala Gln Val 
145                 150                 155                 160 


Val Arg Glu Ser Asn Ala Met Leu Arg Glu Gly Tyr Lys Thr Phe Phe 
                165                 170                 175     


Asn Thr Leu Tyr His Asn Asn Ile Pro Leu Phe Ile Phe Ser Ala Gly 
            180                 185                 190         


Ile Gly Asp Ile Leu Glu Glu Ile Ile Arg Gln Met Lys Val Phe His 
        195                 200                 205             


Pro Asn Ile His Ile Val Ser Asn Tyr Met Asp Phe Asn Glu Asp Gly 
    210                 215                 220                 


Phe Leu Gln Gly Phe Lys Gly Gln Leu Ile His Thr Tyr Asn Lys Asn 
225                 230                 235                 240 


Ser Ser Ala Cys Glu Asn Ser Gly Tyr Phe Gln Gln Leu Glu Gly Lys 
                245                 250                 255     


Thr Asn Val Ile Leu Leu Gly Asp Ser Ile Gly Asp Leu Thr Met Ala 
            260                 265                 270         


Asp Gly Val Pro Gly Val Gln Asn Ile Leu Lys Ile Gly Phe Leu Asn 
        275                 280                 285             


Asp Lys Val Glu Glu Arg Arg Glu Arg Tyr Met Asp Ser Tyr Asp Ile 
    290                 295                 300                 


Val Leu Glu Lys Asp Glu Thr Leu Asp Val Val Asn Gly Leu Leu Gln 
305                 310                 315                 320 


His Ile Leu Cys Gln Gly Val Gln Leu Glu Met Gln Gly Pro 
                325                 330                 


<210> 6838
<211> 176
<212> PRT
<213> Homo sapiens

<400> 6838
Met Ala Ala Ser Thr Asp Met Ala Gly Leu Glu Glu Ser Phe Arg Lys 
1               5                   10                  15      


Phe Ala Ile His Gly Asp Pro Lys Ala Ser Gly Gln Glu Met Asn Gly 
            20                  25                  30          


Lys Asn Trp Ala Lys Leu Cys Lys Asp Cys Lys Val Ala Asp Gly Lys 
        35                  40                  45              


Ser Val Thr Gly Thr Asp Val Asp Ile Val Phe Ser Lys Val Lys Gly 
    50                  55                  60                  


Lys Ser Ala Arg Val Ile Asn Tyr Glu Glu Phe Lys Lys Ala Leu Glu 
65                  70                  75                  80  


Glu Leu Ala Thr Lys Arg Phe Lys Gly Lys Ser Lys Glu Glu Ala Phe 
                85                  90                  95      


Asp Ala Ile Cys Gln Leu Val Ala Gly Lys Glu Pro Ala Asn Val Gly 
            100                 105                 110         


Val Thr Lys Ala Lys Thr Gly Gly Ala Val Asp Arg Leu Thr Asp Thr 
        115                 120                 125             


Ser Arg Tyr Thr Gly Ser His Lys Glu Arg Phe Asp Glu Ser Gly Lys 
    130                 135                 140                 


Gly Lys Gly Ile Ala Gly Arg Gln Asp Ile Leu Asp Asp Ser Gly Tyr 
145                 150                 155                 160 


Val Ser Ala Tyr Lys Asn Ala Gly Thr Tyr Asp Ala Lys Val Lys Lys 
                165                 170                 175     


<210> 6839
<211> 303
<212> PRT
<213> Homo sapiens

<400> 6839
Met Asp Ser Leu Pro Asp Glu Phe Phe Val Arg His Pro Ala Val Glu 
1               5                   10                  15      


Asp Gln Arg Lys Glu Glu Thr Glu Asn Lys Leu Glu Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Asn Lys Gln Glu Asn Asp Ile Pro Thr Asp Leu Val Pro Val 
        35                  40                  45              


Asn Leu Leu Leu Glu Val Lys Lys Leu Leu Asn Ala Ile Asn Thr Leu 
    50                  55                  60                  


Pro Lys Gly Val Val Pro His Ile Lys Lys Phe Leu Gln Glu Asp Phe 
65                  70                  75                  80  


Ser Phe Gln Thr Met Gln Arg Glu Val Ala Ala Asn Ser Gln Asn Gly 
                85                  90                  95      


Glu Glu Ile Val Pro Ala Leu Thr Leu Arg Phe Leu Ile Thr Gln Leu 
            100                 105                 110         


Glu Ala Ala Leu Arg Asn Ile Gln Ala Gly Asn Tyr Thr Ala His Gln 
        115                 120                 125             


Ile Asn Ile Gly Tyr Tyr Leu Thr Leu Leu Phe Leu Tyr Gly Val Ala 
    130                 135                 140                 


Leu Thr Glu Arg Gly Lys Lys Glu Asp Tyr Thr Glu Ala Glu Asn Lys 
145                 150                 155                 160 


Phe Leu Val Met Lys Met Met Ile Gln Glu Asn Glu Ile Cys Glu Asn 
                165                 170                 175     


Phe Met Ser Leu Val Tyr Phe Gly Arg Gly Leu Leu Arg Cys Ala Gln 
            180                 185                 190         


Lys Arg Tyr Asn Gly Gly Leu Leu Glu Phe His Lys Ser Leu Gln Glu 
        195                 200                 205             


Ile Gly Asp Lys Asn Asp His Trp Phe Asp Ile Asp Pro Thr Glu Asp 
    210                 215                 220                 


Glu Asp Leu Pro Thr Thr Phe Lys Asp Leu Leu Asn Asn Phe Ile Lys 
225                 230                 235                 240 


Thr Thr Glu Ser Asn Ile Met Lys Gln Thr Ile Cys Ser Tyr Leu Asp 
                245                 250                 255     


Cys Glu Arg Ser Cys Glu Ala Asp Ile Leu Lys Asn Thr Ser Tyr Lys 
            260                 265                 270         


Gly Phe Phe Gln Leu Met Cys Ser Lys Ser Cys Cys Val Tyr Phe His 
        275                 280                 285             


Lys Ile Cys Trp Lys Lys Phe Lys Asn Leu Lys Tyr Pro Gly Phe 
    290                 295                 300             


<210> 6840
<211> 622
<212> PRT
<213> Homo sapiens

<400> 6840
Met Asp Leu Leu Thr Arg Glu Asn Val Ala Leu Lys Val Glu Ser Ala 
1               5                   10                  15      


Gln Gln Pro Lys Gln Val Leu Lys Met Glu Val Ala Val Leu Lys Lys 
            20                  25                  30          


Leu Gln Gly Lys Asp His Val Cys Arg Phe Ile Gly Cys Gly Arg Asn 
        35                  40                  45              


Glu Lys Phe Asn Tyr Val Val Met Gln Leu Gln Gly Arg Asn Leu Ala 
    50                  55                  60                  


Asp Leu Arg Arg Ser Gln Pro Arg Gly Thr Phe Thr Leu Ser Thr Thr 
65                  70                  75                  80  


Leu Arg Leu Gly Lys Gln Ile Leu Glu Ser Ile Glu Ala Ile His Ser 
                85                  90                  95      


Val Gly Phe Leu His Arg Asp Ile Lys Pro Ser Asn Phe Ala Met Gly 
            100                 105                 110         


Arg Leu Pro Ser Thr Tyr Arg Lys Cys Tyr Met Leu Asp Phe Gly Leu 
        115                 120                 125             


Ala Arg Gln Tyr Thr Asn Thr Thr Gly Asp Val Arg Pro Pro Arg Asn 
    130                 135                 140                 


Val Ala Gly Phe Arg Gly Thr Val Arg Tyr Ala Ser Val Asn Ala His 
145                 150                 155                 160 


Lys Asn Arg Glu Met Gly Arg His Asp Asp Leu Trp Ser Leu Phe Tyr 
                165                 170                 175     


Met Leu Val Glu Phe Ala Val Gly Gln Leu Pro Trp Arg Lys Ile Lys 
            180                 185                 190         


Asp Lys Glu Gln Val Gly Met Ile Lys Glu Lys Tyr Glu His Arg Met 
        195                 200                 205             


Leu Leu Lys His Met Pro Ser Glu Phe His Leu Phe Leu Asp His Ile 
    210                 215                 220                 


Ala Ser Leu Asp Tyr Phe Thr Lys Pro Asp Tyr Gln Leu Ile Met Ser 
225                 230                 235                 240 


Val Phe Glu Asn Ser Met Lys Glu Arg Gly Ile Ala Glu Asn Glu Ala 
                245                 250                 255     


Phe Asp Trp Glu Lys Ala Gly Thr Asp Ala Leu Leu Ser Thr Ser Thr 
            260                 265                 270         


Ser Thr Pro Pro Gln Gln Asn Thr Arg Gln Thr Ala Ala Met Phe Gly 
        275                 280                 285             


Val Val Asn Val Thr Pro Val Pro Gly Asp Leu Leu Arg Glu Asn Thr 
    290                 295                 300                 


Glu Asp Val Leu Gln Gly Glu His Leu Ser Asp Gln Glu Asn Ala Pro 
305                 310                 315                 320 


Pro Ile Leu Pro Gly Arg Pro Ser Glu Gly Leu Gly Pro Ser Pro His 
                325                 330                 335     


Leu Val Pro His Pro Gly Gly Pro Glu Ala Glu Val Trp Glu Glu Thr 
            340                 345                 350         


Asp Val Asn Arg Asn Lys Leu Arg Ile Asn Ile Gly Lys Ser Pro Cys 
        355                 360                 365             


Val Glu Glu Glu Gln Ser Arg Gly Met Gly Val Pro Ser Ser Pro Val 
    370                 375                 380                 


Arg Ala Pro Pro Asp Ser Pro Thr Thr Pro Val Arg Ser Leu Arg Tyr 
385                 390                 395                 400 


Arg Arg Val Asn Ser Pro Glu Ser Glu Arg Leu Ser Thr Ala Asp Gly 
                405                 410                 415     


Arg Val Glu Leu Pro Glu Arg Arg Ser Arg Met Asp Leu Pro Gly Ser 
            420                 425                 430         


Pro Ser Arg Gln Ala Cys Ser Ser Gln Pro Ala Gln Met Leu Ser Val 
        435                 440                 445             


Asp Thr Gly His Ala Asp Arg Gln Ala Ser Gly Arg Met Asp Val Ser 
    450                 455                 460                 


Ala Ser Val Glu Gln Glu Ala Leu Ser Asn Ala Phe Arg Ser Val Pro 
465                 470                 475                 480 


Leu Ala Glu Glu Glu Asp Phe Asp Ser Lys Glu Trp Val Ile Ile Asp 
                485                 490                 495     


Lys Glu Thr Glu Leu Lys Asp Phe Pro Pro Gly Ala Glu Pro Ser Thr 
            500                 505                 510         


Ser Gly Thr Thr Asp Glu Glu Pro Glu Glu Leu Arg Pro Leu Pro Glu 
        515                 520                 525             


Glu Gly Glu Glu Arg Arg Arg Leu Gly Ala Glu Pro Pro Phe Pro Leu 
    530                 535                 540                 


Thr Pro Ala Leu Gly Thr Pro Pro Ser Thr Glu Arg Val Gly Pro His 
545                 550                 555                 560 


Arg Pro Thr Glu Thr Val Gly Gly Gly Gln Thr Leu Gly Ala Leu Pro 
                565                 570                 575     


Pro Ala Val Gln Pro Pro Ala Thr Thr Gly Val Leu Arg Val Leu Leu 
            580                 585                 590         


Leu His Ala Gly Asp Gly Ala Leu Pro Ser Pro Arg Arg Arg Arg Leu 
        595                 600                 605             


Leu Gly Leu Leu Arg Phe Pro His Ser Ala Gln Pro Leu Gly 
    610                 615                 620         


<210> 6841
<211> 148
<212> PRT
<213> Homo sapiens

<400> 6841
Met Ala Ala Ala Met Val Pro Gly Arg Ser Glu Ser Trp Glu Arg Gly 
1               5                   10                  15      


Glu Pro Gly Arg Pro Ala Leu Tyr Phe Cys Gly Ser Ile Arg Gly Gly 
            20                  25                  30          


Arg Glu Asp Arg Thr Leu Tyr Glu Arg Ile Val Ser Arg Leu Arg Arg 
        35                  40                  45              


Phe Gly Thr Val Leu Thr Glu His Val Ala Ala Ala Glu Leu Gly Ala 
    50                  55                  60                  


Arg Gly Glu Glu Ala Ala Gly Gly Asp Arg Leu Ile His Glu Gln Asp 
65                  70                  75                  80  


Leu Glu Trp Leu Gln Gln Ala Asp Val Val Val Ala Glu Val Thr Gln 
                85                  90                  95      


Pro Ser Leu Gly Val Gly Tyr Glu Leu Gly Arg Ala Val Ala Phe Asn 
            100                 105                 110         


Lys Arg Ile Leu Cys Leu Phe Arg Pro Gln Ser Gly Arg Gly Glu His 
        115                 120                 125             


Pro Lys Pro Pro Ser Trp Leu Ser Met Asp Pro Ala Leu Ser Ser Phe 
    130                 135                 140                 


Pro Gly Gly Leu 
145             


<210> 6842
<211> 201
<212> PRT
<213> Homo sapiens

<400> 6842
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Leu Glu Asn Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg 
            20                  25                  30          


Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro 
        35                  40                  45              


Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser 
    50                  55                  60                  


Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys 
65                  70                  75                  80  


Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys 
                85                  90                  95      


Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg 
            100                 105                 110         


Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro 
        115                 120                 125             


Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser 
    130                 135                 140                 


Cys Cys Ile Ser Ser Ser Cys Cys Pro Ser Cys Cys Glu Ser Ser Cys 
145                 150                 155                 160 


Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly Arg Val Ser Cys 
                165                 170                 175     


His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser Thr Cys Pro Arg 
            180                 185                 190         


Pro Leu Cys Cys Ala Ser Ser Cys Cys 
        195                 200     


<210> 6843
<211> 128
<212> PRT
<213> Homo sapiens

<400> 6843
Met Thr Gly Ser Cys Cys Gly Ser Thr Leu Ser Ser Leu Ser Tyr Gly 
1               5                   10                  15      


Gly Gly Cys Cys Gln Pro Cys Cys Cys Arg Asp Pro Cys Cys Cys Arg 
            20                  25                  30          


Pro Val Thr Cys Gln Thr Thr Val Cys Arg Pro Val Thr Cys Val Pro 
        35                  40                  45              


Arg Cys Thr Arg Pro Ile Cys Glu Pro Cys Arg Arg Pro Val Cys Cys 
    50                  55                  60                  


Asp Pro Cys Ser Leu Gln Glu Gly Cys Cys Arg Pro Ile Thr Cys Cys 
65                  70                  75                  80  


Pro Ser Ser Cys Thr Ala Val Val Cys Arg Pro Cys Cys Trp Ala Thr 
                85                  90                  95      


Thr Cys Cys Gln Pro Val Ser Val Gln Ser Pro Cys Cys Arg Pro Pro 
            100                 105                 110         


Cys Gly Gln Pro Thr Pro Cys Ser Thr Thr Cys Arg Thr Ser Ser Cys 
        115                 120                 125             


<210> 6844
<211> 379
<212> PRT
<213> Homo sapiens

<400> 6844
Met Ser Leu Arg Leu Ser Ser Ala Ser Arg Arg Ser Cys Pro Arg Pro 
1               5                   10                  15      


Thr Thr Gly Ser Leu Arg Leu Tyr Gly Gly Gly Thr Ser Phe Gly Thr 
            20                  25                  30          


Gly Asn Ser Cys Gly Ile Ser Gly Ile Gly Ser Gly Phe Ser Ser Ala 
        35                  40                  45              


Phe Gly Gly Ser Ser Ser Gly Gly Asn Thr Gly Gly Gly Asn Pro Cys 
    50                  55                  60                  


Ala Gly Phe Thr Val Asn Glu Arg Gly Leu Leu Ser Gly Asn Glu Lys 
65                  70                  75                  80  


Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Ser 
                85                  90                  95      


Val His Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu Gln Lys Ile Lys 
            100                 105                 110         


Gly Trp Tyr Glu Lys Phe Gly Pro Gly Ser Cys Arg Gly Leu Asp His 
        115                 120                 125             


Asp Tyr Ser Arg Tyr Phe Pro Ile Ile Asp Asp Leu Lys Asn Gln Ile 
    130                 135                 140                 


Ile Ala Ser Thr Thr Ser Asn Ala Asn Ala Val Leu Gln Ile Asp Asn 
145                 150                 155                 160 


Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Leu 
                165                 170                 175     


Ala Leu His Gln Ser Val Glu Ala Asp Val Asn Gly Leu Arg Arg Val 
            180                 185                 190         


Leu Asp Glu Ile Thr Leu Cys Arg Thr Asp Leu Glu Ile Gln Tyr Glu 
        195                 200                 205             


Thr Leu Ser Glu Glu Met Thr Tyr Leu Lys Lys Asn His Lys Glu Glu 
    210                 215                 220                 


Met Gln Val Leu Gln Cys Ala Ala Gly Gly Asn Val Asn Val Glu Ile 
225                 230                 235                 240 


Glu Leu Gln Ser Leu Leu Ala Thr Lys His Ser Leu Glu Cys Ser Leu 
                245                 250                 255     


Thr Glu Thr Glu Ser Asn Tyr Cys Ala Gln Leu Ala Gln Ile Gln Ala 
            260                 265                 270         


Gln Ile Gly Ala Leu Glu Glu Gln Leu His Gln Val Arg Thr Glu Thr 
        275                 280                 285             


Glu Gly Gln Lys Leu Glu Tyr Glu Gln Leu Leu Asp Ile Lys Leu His 
    290                 295                 300                 


Leu Glu Lys Glu Ile Glu Thr Tyr Cys Leu Leu Ile Gly Gly Asp Asp 
305                 310                 315                 320 


Gly Ala Cys Lys Ser Gly Gly Tyr Lys Ser Lys Asp Tyr Gly Ser Gly 
                325                 330                 335     


Asn Val Gly Ser Gln Val Lys Asp Pro Ala Lys Ala Ile Val Val Lys 
            340                 345                 350         


Lys Val Leu Glu Glu Val Asp Gln Arg Ser Lys Ile Leu Thr Thr Arg 
        355                 360                 365             


Leu His Ser Leu Glu Glu Lys Ser Gln Ser Asn 
    370                 375                 


<210> 6845
<211> 255
<212> PRT
<213> Homo sapiens

<400> 6845
Met Asp Lys Asp Glu Glu Ala Leu Lys Ala Ala Gln Ala Glu Leu Lys 
1               5                   10                  15      


Glu Ala Arg Arg Gln Trp His His Leu Gln Val Glu Ile Glu Ser Leu 
            20                  25                  30          


His Ala Val Glu Arg Gly Leu Glu Asn Ser Leu His Ala Ser Glu Gln 
        35                  40                  45              


His Tyr Gln Met Gln Leu Gln Asp Leu Glu Thr Val Ile Glu Gly Leu 
    50                  55                  60                  


Glu Lys Glu Leu Gln Glu Val Arg Arg Gly Ile Glu Lys Gln Leu Gln 
65                  70                  75                  80  


Glu His Glu Met Leu Leu Asn Thr Lys Met Arg Leu Glu Gln Glu Ile 
                85                  90                  95      


Ala Thr Tyr Arg His Leu Leu Glu Lys Glu Glu Ile Arg Tyr Tyr Gly 
            100                 105                 110         


Cys Ile Gln Gly Gly Lys Lys Asp Lys Lys Pro Thr Thr Ser Arg Val 
        115                 120                 125             


Gly Phe Val Leu Pro Ser Ala Ile Ile Asn Glu Ile Ser Phe Thr Thr 
    130                 135                 140                 


Lys Val Pro Gln Lys Tyr Glu Asn Glu Asn Val Glu Thr Val Thr Lys 
145                 150                 155                 160 


Gln Ala Ile Leu Asn Gly Ser Ile Val Lys Glu Ser Thr Glu Ala His 
                165                 170                 175     


Gly Thr Ile Gln Thr Glu Lys Val Asp Glu Val Ile Lys Glu Trp Glu 
            180                 185                 190         


Gly Ser Phe Phe Lys Asp Asn Pro Arg Leu Arg Lys Lys Ser Val Ser 
        195                 200                 205             


Leu Arg Phe Asp Leu His Leu Ala Ala Thr Asp Glu Gly Cys Leu Glu 
    210                 215                 220                 


Thr Lys Gln Asp Asn Leu Pro Asp Ile Glu Val Arg Leu Ile Met Arg 
225                 230                 235                 240 


Arg Ser Cys Ser Ile Pro Ser Ile Lys Pro Pro Ser Thr Ala Asn 
                245                 250                 255 


<210> 6846
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6846
Met Glu Leu Ser Gln Leu Leu Asn Glu Ile Arg Ala Asn Tyr Glu Lys 
1               5                   10                  15      


Ile Leu Thr Arg Asn Gln Ile Glu Thr Val Leu Ser Thr Arg Ile Gln 
            20                  25                  30          


Leu Glu Glu Asp Ile Ser Lys Lys Met Asp Lys Asp Glu Glu Ala Leu 
        35                  40                  45              


Lys Ala Ala Gln Ala Glu Leu Lys Glu Ala Arg Arg Gln Trp His His 
    50                  55                  60                  


Leu Gln Val Glu Ile Glu Ser Leu His Ala Val Glu Arg Gly Leu Glu 
65                  70                  75                  80  


Asn Ser Leu His Ala Ser Glu Gln His Tyr Gln Met Gln Leu Gln Asp 
                85                  90                  95      


Leu Glu Thr Val Ile Glu Gly Leu Glu Lys Glu Leu Gln Glu Val Arg 
            100                 105                 110         


Arg Gly Ile Glu Lys Gln Leu Gln Glu His Glu Met Leu Leu Asn Thr 
        115                 120                 125             


Lys Met Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg His Leu Leu Glu 
    130                 135                 140                 


Lys Glu Glu Ile Arg Tyr Tyr Gly Cys Ile Gln Gly Gly Lys Lys Asp 
145                 150                 155                 160 


Lys Lys Pro Thr Thr Ser Arg Val Gly Phe Val Leu Pro Ser Ala Ile 
                165                 170                 175     


Ile Asn Glu Ile Ser Phe Thr Thr Lys Val Pro Gln Lys Tyr Glu Asn 
            180                 185                 190         


Glu Asn Val Glu Thr Val Thr Lys Gln Ala Ile Leu Asn Gly Ser Ile 
        195                 200                 205             


Val Lys Glu Ser Thr Glu Ala His Gly Thr Ile Gln Thr Glu Lys Val 
    210                 215                 220                 


Asp Glu Val Ile Lys Glu Trp Glu Gly Ser Phe Phe Lys Asp Asn Pro 
225                 230                 235                 240 


Arg Leu Arg Lys Lys Ser Val Ser Leu Arg Phe Asp Leu His Leu Ala 
                245                 250                 255     


Ala Thr Asp Glu Gly Cys Leu Glu Thr Lys Gln Asp Asn Leu Pro Asp 
            260                 265                 270         


Ile Glu Val Arg Leu Ile Met Arg Arg Ser Cys Ser Ile Pro Ser Ile 
        275                 280                 285             


Lys Pro Pro Ser Thr Ala Asn 
    290                 295 


<210> 6847
<211> 619
<212> PRT
<213> Homo sapiens

<400> 6847
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu Ala Gln Val Met Leu Ala Leu Ala Ser His Leu Ser 
                85                  90                  95      


Thr Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu 
            100                 105                 110         


Cys Gln Glu Asn Gln Trp Leu Arg Asp Glu Leu Ala Gly Thr Gln Gln 
        115                 120                 125             


Arg Leu Gln Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu Glu Lys 
    130                 135                 140                 


Lys His Leu Glu Phe Leu Gly Gln Leu Arg Gln Tyr Asp Glu Asp Gly 
145                 150                 155                 160 


His Thr Ser Glu Glu Lys Glu Gly Asp Ala Thr Lys Asp Ser Leu Asp 
                165                 170                 175     


Asp Leu Phe Pro Asn Glu Glu Glu Glu Asp Pro Ser Asn Gly Leu Ser 
            180                 185                 190         


Arg Gly Gln Gly Ala Thr Ala Ala Gln Gln Gly Gly Tyr Glu Ile Pro 
        195                 200                 205             


Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala Ala Gln 
    210                 215                 220                 


Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu Glu Asp 
225                 230                 235                 240 


Leu Glu Arg Thr Ser Gly Arg Gly His Pro Asp Val Ala Thr Met Leu 
                245                 250                 255     


Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys Glu Ala 
            260                 265                 270         


Ala His Leu Leu Asn Asp Ala Leu Ser Ile Arg Glu Ser Thr Leu Gly 
        275                 280                 285             


Pro Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu Ala Val Leu 
    290                 295                 300                 


Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu Cys Gln Arg 
305                 310                 315                 320 


Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Thr Asn His Pro Asp Val 
                325                 330                 335     


Ala Lys Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn Gln Gly Lys 
            340                 345                 350         


Tyr Glu Ala Val Glu Arg Tyr Tyr Gln Arg Ala Leu Ala Ile Tyr Glu 
        355                 360                 365             


Gly Gln Leu Gly Pro Asp Asn Pro Asn Val Ala Arg Thr Lys Asn Asn 
    370                 375                 380                 


Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Tyr Ala Glu Ala Glu Thr 
385                 390                 395                 400 


Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Val Gln Glu Phe Gly Ser 
                405                 410                 415     


Val Asp Asp Asp His Lys Pro Ile Trp Met His Ala Glu Glu Arg Glu 
            420                 425                 430         


Glu Met Ser Lys Ser Arg His His Glu Gly Gly Thr Pro Tyr Ala Glu 
        435                 440                 445             


Tyr Gly Gly Trp Tyr Lys Ala Cys Lys Val Ser Ser Pro Thr Val Asn 
    450                 455                 460                 


Thr Thr Leu Arg Asn Leu Gly Ala Leu Tyr Arg Arg Gln Gly Lys Leu 
465                 470                 475                 480 


Glu Ala Ala Glu Thr Leu Glu Glu Cys Ala Leu Arg Ser Arg Arg Gln 
                485                 490                 495     


Gly Thr Asp Pro Ile Ser Gln Thr Lys Val Ala Glu Leu Leu Gly Glu 
            500                 505                 510         


Ser Asp Gly Arg Arg Thr Ser Gln Glu Gly Pro Gly Asp Ser Val Lys 
        515                 520                 525             


Phe Glu Gly Gly Glu Asp Ala Ser Val Ala Val Glu Trp Ser Gly Asp 
    530                 535                 540                 


Gly Ser Gly Thr Leu Gln Arg Ser Gly Ser Leu Gly Lys Ile Arg Asp 
545                 550                 555                 560 


Val Leu Arg Arg Ser Ser Glu Leu Leu Val Arg Lys Leu Gln Gly Thr 
                565                 570                 575     


Glu Pro Arg Pro Ser Ser Ser Asn Met Lys Arg Ala Ala Ser Leu Asn 
            580                 585                 590         


Tyr Leu Asn Gln Pro Ser Ala Ala Pro Leu Gln Val Ser Arg Gly Leu 
        595                 600                 605             


Ser Ala Ser Thr Met Asp Leu Ser Ser Ser Ser 
    610                 615                 


<210> 6848
<211> 619
<212> PRT
<213> Homo sapiens

<400> 6848
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu Ala Gln Val Met Leu Ala Leu Ala Ser His Leu Ser 
                85                  90                  95      


Thr Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu 
            100                 105                 110         


Cys Gln Glu Asn Gln Trp Leu Arg Asp Glu Leu Ala Gly Thr Gln Gln 
        115                 120                 125             


Arg Leu Gln Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu Glu Lys 
    130                 135                 140                 


Lys His Leu Glu Phe Leu Gly Gln Leu Arg Gln Tyr Asp Glu Asp Gly 
145                 150                 155                 160 


His Thr Ser Glu Glu Lys Glu Gly Asp Ala Thr Lys Asp Ser Leu Asp 
                165                 170                 175     


Asp Leu Phe Pro Asn Glu Glu Glu Glu Asp Pro Ser Asn Gly Leu Ser 
            180                 185                 190         


Arg Gly Gln Gly Ala Thr Ala Ala Gln Gln Gly Gly Tyr Glu Ile Pro 
        195                 200                 205             


Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala Ala Gln 
    210                 215                 220                 


Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu Glu Asp 
225                 230                 235                 240 


Leu Glu Arg Thr Ser Gly Arg Gly His Pro Asp Val Ala Thr Met Leu 
                245                 250                 255     


Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys Glu Ala 
            260                 265                 270         


Ala His Leu Leu Asn Asp Ala Leu Ser Ile Arg Glu Ser Thr Leu Gly 
        275                 280                 285             


Pro Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu Ala Val Leu 
    290                 295                 300                 


Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu Cys Gln Arg 
305                 310                 315                 320 


Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Thr Asn His Pro Asp Val 
                325                 330                 335     


Ala Lys Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn Gln Gly Lys 
            340                 345                 350         


Tyr Glu Ala Val Glu Arg Tyr Tyr Gln Arg Ala Leu Ala Ile Tyr Glu 
        355                 360                 365             


Gly Gln Leu Gly Pro Asp Asn Pro Asn Val Ala Arg Thr Lys Asn Asn 
    370                 375                 380                 


Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Tyr Ala Glu Ala Glu Thr 
385                 390                 395                 400 


Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Val Gln Glu Phe Gly Ser 
                405                 410                 415     


Val Asp Asp Asp His Lys Pro Ile Trp Met His Ala Glu Glu Arg Glu 
            420                 425                 430         


Glu Met Ser Lys Ser Arg His His Glu Gly Gly Thr Pro Tyr Ala Glu 
        435                 440                 445             


Tyr Gly Gly Trp Tyr Lys Ala Cys Lys Val Ser Ser Pro Thr Val Asn 
    450                 455                 460                 


Thr Thr Leu Arg Asn Leu Gly Ala Leu Tyr Arg Arg Gln Gly Lys Leu 
465                 470                 475                 480 


Glu Ala Ala Glu Thr Leu Glu Glu Cys Ala Leu Arg Ser Arg Arg Gln 
                485                 490                 495     


Gly Thr Asp Pro Ile Ser Gln Thr Lys Val Ala Glu Leu Leu Gly Glu 
            500                 505                 510         


Ser Asp Gly Arg Arg Thr Ser Gln Glu Gly Pro Gly Asp Ser Val Lys 
        515                 520                 525             


Phe Glu Gly Gly Glu Asp Ala Ser Val Ala Val Glu Trp Ser Gly Asp 
    530                 535                 540                 


Gly Ser Gly Thr Leu Gln Arg Ser Gly Ser Leu Gly Lys Ile Arg Asp 
545                 550                 555                 560 


Val Leu Arg Arg Ser Ser Glu Leu Leu Val Arg Lys Leu Gln Gly Thr 
                565                 570                 575     


Glu Pro Arg Pro Ser Ser Ser Asn Met Lys Arg Ala Ala Ser Leu Asn 
            580                 585                 590         


Tyr Leu Asn Gln Pro Ser Ala Ala Pro Leu Gln Val Ser Arg Gly Leu 
        595                 600                 605             


Ser Ala Ser Thr Met Asp Leu Ser Ser Ser Ser 
    610                 615                 


<210> 6849
<211> 389
<212> PRT
<213> Homo sapiens

<400> 6849
Met Leu Arg Trp Thr Val His Leu Glu Gly Gly Pro Arg Arg Val Asn 
1               5                   10                  15      


His Ala Ala Val Ala Val Gly His Arg Val Tyr Ser Phe Gly Gly Tyr 
            20                  25                  30          


Cys Ser Gly Glu Asp Tyr Glu Thr Leu Arg Gln Ile Asp Val His Ile 
        35                  40                  45              


Phe Asn Ala Val Ser Leu Arg Trp Thr Lys Leu Pro Pro Val Lys Ser 
    50                  55                  60                  


Ala Ile Arg Gly Gln Ala Pro Val Val Pro Tyr Met Arg Tyr Gly His 
65                  70                  75                  80  


Ser Thr Val Leu Ile Asp Asp Thr Val Leu Leu Trp Gly Gly Arg Asn 
                85                  90                  95      


Asp Thr Glu Gly Ala Cys Asn Val Leu Tyr Ala Phe Asp Val Asn Thr 
            100                 105                 110         


His Lys Trp Phe Thr Pro Arg Val Ser Gly Thr Val Pro Gly Ala Arg 
        115                 120                 125             


Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile Met Tyr Ile Phe Gly 
    130                 135                 140                 


Gly Tyr Glu Gln Gln Ala Asp Cys Phe Ser Asn Asp Ile His Lys Leu 
145                 150                 155                 160 


Asp Thr Ser Thr Met Thr Trp Thr Leu Ile Cys Thr Lys Gly Ser Pro 
                165                 170                 175     


Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met Leu Gly Ser His Met 
            180                 185                 190         


Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly Pro Phe His Ser Asn 
        195                 200                 205             


Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe Asp Thr Arg Thr Glu 
    210                 215                 220                 


Ala Trp Leu Asp Cys Pro Pro Thr Pro Val Leu Pro Glu Gly Arg Arg 
225                 230                 235                 240 


Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu Tyr Ile Phe Gly Gly 
                245                 250                 255     


Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp Leu Trp Lys Phe Asn 
            260                 265                 270         


Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro Lys Gly Lys Gly Pro 
        275                 280                 285             


Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val Gly Asp Lys Ile Val 
    290                 295                 300                 


Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu Gly Leu Gly Asp Glu 
305                 310                 315                 320 


Phe Asp Leu Ile Asp His Ser Asp Leu His Ile Leu Asp Phe Ser Pro 
                325                 330                 335     


Ser Leu Lys Thr Leu Cys Lys Leu Ala Val Ile Gln Tyr Asn Leu Asp 
            340                 345                 350         


Gln Ser Cys Leu Pro His Asp Ile Arg Trp Glu Leu Asn Ala Met Thr 
        355                 360                 365             


Thr Asn Ser Asn Ile Ser Arg Pro Ile Val Ser Ser Pro Phe Ala Tyr 
    370                 375                 380                 


Pro Leu Pro Ser Ala 
385                 


<210> 6850
<211> 182
<212> PRT
<213> Homo sapiens

<400> 6850
Met Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Thr Phe His Gln Ala Asn Thr Glu Gln Pro Lys Leu Ser Arg Asp 
            20                  25                  30          


Glu Gln Arg Gly Arg Gly Ala Leu Leu Gln Asp Ile Cys Lys Gly Thr 
        35                  40                  45              


Lys Leu Lys Lys Val Thr Asn Ile Asn Asp Arg Ser Ala Pro Ile Leu 
    50                  55                  60                  


Glu Thr Pro Pro Pro Pro Pro Pro Val Ile Arg Asn Gly Ala Arg Asp 
65                  70                  75                  80  


Ala Pro Pro Pro Pro Pro Pro Tyr Arg Met His Gly Ser Glu Pro Pro 
                85                  90                  95      


Ser Arg Gly Lys Pro Pro Pro Pro Pro Ser Arg Thr Pro Ala Gly Pro 
            100                 105                 110         


Pro Pro Pro Pro Pro Pro Pro Leu Arg Asn Gly His Arg Asp Ser Ile 
        115                 120                 125             


Thr Thr Val Arg Ser Phe Leu Asp Asp Phe Glu Ser Lys Tyr Ser Phe 
    130                 135                 140                 


His Pro Val Glu Asp Phe Pro Ala Pro Glu Glu Tyr Lys His Phe Gln 
145                 150                 155                 160 


Arg Ile Tyr Pro Ser Lys Thr Asn Arg Ala Ala Arg Gly Ala Pro Pro 
                165                 170                 175     


Leu Pro Pro Ile Leu Arg 
            180         


<210> 6851
<211> 276
<212> PRT
<213> Homo sapiens

<400> 6851
Met Thr Ser Phe Arg Leu Ala Leu Ile Gln Leu Gln Ile Ser Ser Ile 
1               5                   10                  15      


Lys Ser Asp Asn Val Thr Arg Ala Cys Ser Phe Ile Arg Glu Ala Ala 
            20                  25                  30          


Thr Gln Gly Ala Lys Ile Val Ser Leu Pro Glu Cys Phe Asn Ser Pro 
        35                  40                  45              


Tyr Gly Ala Lys Tyr Phe Pro Glu Tyr Ala Glu Lys Ile Pro Gly Glu 
    50                  55                  60                  


Ser Thr Gln Lys Leu Ser Glu Val Ala Lys Glu Cys Ser Ile Tyr Leu 
65                  70                  75                  80  


Ile Gly Gly Ser Ile Pro Glu Glu Asp Ala Gly Lys Leu Tyr Asn Thr 
                85                  90                  95      


Cys Ala Val Phe Gly Pro Asp Gly Thr Leu Leu Ala Lys Tyr Arg Lys 
            100                 105                 110         


Ile His Leu Phe Asp Ile Asp Val Pro Gly Lys Ile Thr Phe Gln Glu 
        115                 120                 125             


Ser Lys Thr Leu Ser Pro Gly Asp Ser Phe Ser Thr Phe Asp Thr Pro 
    130                 135                 140                 


Tyr Cys Arg Val Gly Leu Gly Ile Cys Tyr Asp Met Arg Phe Ala Glu 
145                 150                 155                 160 


Leu Ala Gln Ile Tyr Ala Gln Arg Gly Cys Gln Leu Leu Val Tyr Pro 
                165                 170                 175     


Gly Ala Phe Asn Leu Thr Thr Gly Pro Ala His Trp Glu Leu Leu Gln 
            180                 185                 190         


Arg Ser Arg Ala Val Asp Asn Gln Val Tyr Val Ala Thr Ala Ser Pro 
        195                 200                 205             


Ala Arg Asp Asp Lys Ala Ser Tyr Val Ala Trp Gly His Ser Thr Val 
    210                 215                 220                 


Val Asn Pro Trp Gly Glu Val Leu Ala Lys Ala Gly Thr Glu Glu Ala 
225                 230                 235                 240 


Ile Val Tyr Ser Asp Ile Asp Leu Lys Lys Leu Ala Glu Ile Arg Gln 
                245                 250                 255     


Gln Ile Pro Val Phe Arg Gln Lys Arg Ser Asp Leu Tyr Ala Val Glu 
            260                 265                 270         


Met Lys Lys Pro 
        275     


<210> 6852
<211> 491
<212> PRT
<213> Homo sapiens

<400> 6852
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Asp Gly Glu 
        35                  40                  45              


Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys Ile Ser Glu 
    50                  55                  60                  


Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys His Asp Ile 
65                  70                  75                  80  


Thr Gln Val Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu Asp Arg Leu 
                85                  90                  95      


Glu Arg Leu Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu Glu Arg Glu 
            100                 105                 110         


Phe Arg Gln Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser Glu Lys Asn 
        115                 120                 125             


Asn Glu Cys His Glu Pro Glu Lys Ser Phe Ser Leu Asp Ser Thr Ile 
    130                 135                 140                 


Asp Ala Asp Gln Arg Val Leu Arg Ile Gln Asn Thr Asp Asp Asn Asp 
145                 150                 155                 160 


Lys Tyr Asp Met Ser Phe Asn Gln Asn Ser Ala Ser Gly Lys His Glu 
                165                 170                 175     


His Leu Asn Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys Lys Glu Ser 
            180                 185                 190         


Leu Met Asp Leu Ser His Leu Asn Lys Trp Glu Ser Ile Pro Asn Thr 
        195                 200                 205             


Glu Lys Ser Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe His Gln Ser 
    210                 215                 220                 


Ser Ala Leu Thr Arg His Gln Arg Ile His Thr Arg Glu Lys Pro Tyr 
225                 230                 235                 240 


Lys Cys Lys Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser Ser Leu Ser 
                245                 250                 255     


Arg His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Ala 
            260                 265                 270         


Ser Asp Lys Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser Pro Ser Ser 
        275                 280                 285             


Gly Ile Ile Gln His Lys Lys Ile His Thr Arg Ala Lys Ser Tyr Lys 
    290                 295                 300                 


Cys Ser Ser Cys Glu Arg Val Phe Ser Arg Ser Val His Leu Thr Gln 
305                 310                 315                 320 


His Gln Lys Ile His Lys Glu Met Pro Cys Lys Cys Thr Val Cys Gly 
                325                 330                 335     


Ser Asp Phe Cys His Thr Ser Tyr Leu Leu Glu His Gln Arg Val His 
            340                 345                 350         


His Glu Glu Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu Ala Tyr Ile 
        355                 360                 365             


Lys Gln Gln Gly Ile His Phe Arg Glu Lys Pro Tyr Thr Cys Ser Glu 
    370                 375                 380                 


Cys Gly Lys Asp Phe Arg Leu Asn Ser His Leu Ile Gln His Gln Arg 
385                 390                 395                 400 


Ile His Thr Gly Glu Lys Ala His Glu Cys Asn Glu Cys Gly Lys Ala 
                405                 410                 415     


Phe Ser Gln Thr Ser Cys Leu Ile Gln His His Lys Met His Arg Lys 
            420                 425                 430         


Glu Lys Ser Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe Ser His Ser 
        435                 440                 445             


Ser Asp Leu Ile Leu Gln Gln Glu Val Leu Thr Arg Gln Lys Ala Phe 
    450                 455                 460                 


Asp Cys Asp Val Trp Glu Lys Asn Ser Ser Gln Arg Ala His Leu Val 
465                 470                 475                 480 


Gln His Gln Ser Ile His Thr Lys Glu Asn Ser 
                485                 490     


<210> 6853
<211> 362
<212> PRT
<213> Homo sapiens

<400> 6853
Met Ala His Ser Ser Phe Phe Pro Asp Glu Tyr Phe Thr Cys Ser Ser 
1               5                   10                  15      


Leu Cys Leu Ser Cys Gly Val Gly Cys Lys Lys Ser Met Asn His Gly 
            20                  25                  30          


Lys Glu Gly Val Pro His Glu Ala Lys Ser Arg Cys Arg Tyr Ser His 
        35                  40                  45              


Gln Tyr Asp Asn Arg Val Tyr Thr Cys Lys Ala Cys Tyr Glu Arg Gly 
    50                  55                  60                  


Glu Glu Val Ser Val Val Pro Lys Thr Ser Ala Ser Thr Asp Ser Pro 
65                  70                  75                  80  


Trp Met Gly Leu Ala Lys Tyr Ala Trp Ser Gly Tyr Val Ile Glu Cys 
                85                  90                  95      


Pro Asn Cys Gly Val Val Tyr Arg Ser Arg Gln Tyr Trp Phe Gly Asn 
            100                 105                 110         


Gln Asp Pro Val Asp Thr Val Val Arg Thr Glu Ile Val His Val Trp 
        115                 120                 125             


Pro Gly Thr Asp Gly Phe Leu Lys Asp Asn Asn Asn Ala Ala Gln Arg 
    130                 135                 140                 


Leu Leu Asp Gly Met Asn Phe Met Ala Gln Ser Val Ser Glu Leu Ser 
145                 150                 155                 160 


Leu Gly Pro Thr Lys Ala Val Thr Ser Trp Leu Thr Asp Gln Ile Ala 
                165                 170                 175     


Pro Ala Tyr Trp Arg Pro Asn Ser Gln Ile Leu Ser Cys Asn Lys Cys 
            180                 185                 190         


Ala Thr Ser Phe Lys Asp Asn Asp Thr Lys His His Cys Arg Ala Cys 
        195                 200                 205             


Gly Glu Gly Phe Cys Asp Ser Cys Ser Ser Lys Thr Arg Pro Val Pro 
    210                 215                 220                 


Glu Arg Gly Trp Gly Pro Ala Pro Val Arg Val Cys Asp Asn Cys Tyr 
225                 230                 235                 240 


Glu Ala Arg Asn Val Gln Leu Ala Val Thr Glu Ala Gln Val Asp Asp 
                245                 250                 255     


Glu Gly Gly Thr Leu Ile Ala Arg Lys Val Gly Glu Ala Val Gln Asn 
            260                 265                 270         


Thr Leu Gly Ala Val Val Thr Ala Ile Asp Ile Pro Leu Gly Leu Val 
        275                 280                 285             


Lys Asp Ala Ala Arg Pro Ala Tyr Trp Val Pro Asp His Glu Ile Leu 
    290                 295                 300                 


His Cys His Asn Cys Arg Lys Glu Phe Ser Ile Lys Leu Ser Lys His 
305                 310                 315                 320 


His Cys Arg Ala Cys Gly Gln Gly Phe Cys Asp Glu Cys Ser His Asp 
                325                 330                 335     


Arg Arg Ala Val Pro Ser Arg Gly Trp Asp His Pro Val Arg Val Cys 
            340                 345                 350         


Phe Asn Cys Asn Lys Lys Pro Gly Asp Leu 
        355                 360         


<210> 6854
<211> 115
<212> PRT
<213> Homo sapiens

<400> 6854
Met Ser Gly Glu Pro Gly Gln Thr Ser Val Ala Pro Pro Pro Glu Glu 
1               5                   10                  15      


Val Glu Pro Gly Ser Gly Val Arg Ile Val Val Glu Tyr Cys Glu Pro 
            20                  25                  30          


Cys Gly Phe Glu Ala Thr Tyr Leu Glu Leu Ala Ser Ala Val Lys Glu 
        35                  40                  45              


Gln Tyr Pro Gly Ile Glu Ile Glu Ser Arg Leu Gly Gly Thr Gly Ala 
    50                  55                  60                  


Phe Glu Ile Glu Ile Asn Gly Gln Leu Val Phe Ser Lys Leu Glu Asn 
65                  70                  75                  80  


Gly Gly Phe Pro Tyr Glu Lys Asp Leu Ile Glu Ala Ile Arg Arg Ala 
                85                  90                  95      


Ser Asn Gly Glu Thr Leu Glu Lys Ile Thr Asn Ser Arg Pro Pro Cys 
            100                 105                 110         


Val Ile Leu 
        115 


<210> 6855
<211> 168
<212> PRT
<213> Homo sapiens

<400> 6855
Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu Glu Glu Ala Ser 
1               5                   10                  15      


Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu Lys Ser Lys Arg 
            20                  25                  30          


Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys Ala Val Gln Arg 
        35                  40                  45              


Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu Asn Glu Asn Gln 
    50                  55                  60                  


Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg Glu Leu Gly Tyr 
65                  70                  75                  80  


Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val Ile Arg Gln Ser 
            100                 105                 110         


Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu Gly Pro Trp Glu 
        115                 120                 125             


Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly Gly Ser Glu Asp 
    130                 135                 140                 


Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu Glu Pro Gln Arg 
145                 150                 155                 160 


Pro Ser Pro Ser Glu Pro Gly Thr 
                165             


<210> 6856
<211> 168
<212> PRT
<213> Homo sapiens

<400> 6856
Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu Glu Glu Ala Ser 
1               5                   10                  15      


Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu Lys Ser Lys Arg 
            20                  25                  30          


Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys Ala Val Gln Arg 
        35                  40                  45              


Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu Asn Glu Asn Gln 
    50                  55                  60                  


Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg Glu Leu Gly Tyr 
65                  70                  75                  80  


Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val Ile Arg Gln Ser 
            100                 105                 110         


Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu Gly Pro Trp Glu 
        115                 120                 125             


Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly Gly Ser Glu Asp 
    130                 135                 140                 


Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu Glu Pro Gln Arg 
145                 150                 155                 160 


Pro Ser Pro Ser Glu Pro Gly Thr 
                165             


<210> 6857
<211> 215
<212> PRT
<213> Homo sapiens

<400> 6857
Met Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro 
1               5                   10                  15      


Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu 
        35                  40                  45              


Glu Glu Ala Ser Pro His Gln Val Thr Pro Leu Thr Trp His Phe Pro 
    50                  55                  60                  


Trp Gln Arg Ala Ser Gly Glu Gly His His Leu Lys Ser Lys Arg Pro 
65                  70                  75                  80  


Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys Ala Val Gln Arg Ile 
                85                  90                  95      


Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu Asn Glu Asn Gln Ala 
            100                 105                 110         


Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg Glu Leu Gly Tyr Pro 
        115                 120                 125             


Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val Ile Arg Gln Ser Ala 
145                 150                 155                 160 


Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu Gly Pro Trp Glu Arg 
                165                 170                 175     


Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly Gly Ser Glu Asp Gln 
            180                 185                 190         


Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu Glu Pro Gln Arg Pro 
        195                 200                 205             


Ser Pro Ser Glu Pro Gly Thr 
    210                 215 


<210> 6858
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 6858
Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      


Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          


Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              


Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  


Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  


Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      


Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         


Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             


Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 


Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 


Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     


Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         


Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        195                 200                 205             


Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    210                 215                 220                 


Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                245                 250                 255     


Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            260                 265                 270         


Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        275                 280                 285             


Pro Val Ser Ser Lys Phe Gln Lys Arg Lys Met Leu Arg Leu Ser Gln 
    290                 295                 300                 


Asp Val Lys Gly Tyr Ser Phe Ile Lys Asp Leu Gln Trp Ile Gln Val 
305                 310                 315                 320 


Ser Asp Ser Lys Glu Ala Tyr Arg Leu Leu Lys Leu Gly Ile Lys His 
                325                 330                 335     


Gln Ser Val Ala Phe Thr Lys Leu Asn Asn Ala Ser Ser Arg Ser His 
            340                 345                 350         


Ser Ile Phe Thr Val Lys Ile Leu Gln Ile Glu Asp Ser Glu Met Ser 
        355                 360                 365             


Arg Val Ile Arg Val Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser 
    370                 375                 380                 


Glu Arg Thr Met Lys Thr Gln Asn Glu Gly Glu Arg Leu Arg Glu Thr 
385                 390                 395                 400 


Gly Asn Ile Asn Thr Ser Leu Leu Thr Leu Gly Lys Cys Ile Asn Val 
                405                 410                 415     


Leu Lys Asn Ser Glu Lys Ser Lys Phe Gln Gln His Val Pro Phe Arg 
            420                 425                 430         


Glu Ser Lys Leu Thr His Tyr Phe Gln Ser Phe Phe Asn Gly Lys Gly 
        435                 440                 445             


Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala Tyr Asp 
    450                 455                 460                 


Glu Thr Leu Asn Val Leu Lys Phe Ser Ala Ile Ala Gln Lys Val Cys 
465                 470                 475                 480 


Val Pro Asp Thr Leu Asn Ser Ser Gln Glu Lys Leu Phe Gly Pro Val 
                485                 490                 495     


Lys Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys Ile 
            500                 505                 510         


Leu Asn Val Lys Arg Ala Thr Ile Ser Trp Glu Asn Ser Leu Glu Asp 
        515                 520                 525             


Leu Met Glu Asp Glu Asp Leu Val Glu Glu Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


Thr Gln Asn Val Glu Thr Lys Leu Leu Asp Glu Asp Leu Asp Lys Thr 
545                 550                 555                 560 


Leu Glu Glu Asn Lys Ala Phe Ile Ser His Glu Glu Lys Arg Lys Leu 
                565                 570                 575     


Leu Asp Leu Ile Glu Asp Leu Lys Lys Lys Leu Ile Asn Glu Lys Lys 
            580                 585                 590         


Glu Lys Leu Thr Leu Glu Phe Lys Ile Arg Glu Glu Val Thr Gln Glu 
        595                 600                 605             


Phe Thr Gln Tyr Trp Ala Gln Arg Glu Ala Asp Phe Lys Glu Thr Leu 
    610                 615                 620                 


Leu Gln Glu Arg Glu Ile Leu Glu Glu Asn Ala Glu Arg Arg Leu Ala 
625                 630                 635                 640 


Ile Phe Lys Asp Leu Val Gly Lys Cys Asp Thr Arg Glu Glu Ala Ala 
                645                 650                 655     


Lys Asp Ile Cys Ala Thr Lys Val Glu Thr Glu Glu Thr His Asn Tyr 
            660                 665                 670         


Val Gly Phe Glu Asp Ile Ile Asp Ser Leu Gln Asp Asn Val Ala Asp 
        675                 680                 685             


Ile Lys Lys Gln Ala Glu Ile Ala His Leu Tyr Ile Ala Ser Leu Pro 
    690                 695                 700                 


Asp Pro Gln Glu Ala Thr Ala Cys Leu Glu Leu Lys Phe Asn Gln Ile 
705                 710                 715                 720 


Lys Ala Glu Leu Ala Lys Thr Lys Gly Glu Leu Ile Lys Thr Lys Glu 
                725                 730                 735     


Glu Leu Lys Lys Arg Glu Asn Glu Ser Asp Ser Leu Ile Gln Glu Leu 
            740                 745                 750         


Glu Thr Ser Asn Lys Lys Ile Ile Thr Gln Asn Gln Arg Ile Lys Glu 
        755                 760                 765             


Leu Ile Asn Ile Ile Asp Gln Lys Glu Asp Thr Ile Asn Glu Phe Gln 
    770                 775                 780                 


Asn Leu Lys Ser His Met Glu Asn Thr Phe Lys Cys Asn Asp Lys Ala 
785                 790                 795                 800 


Asp Thr Ser Ser Leu Ile Ile Asn Asn Lys Leu Ile Cys Asn Glu Thr 
                805                 810                 815     


Val Glu Val Pro Lys Asp Ser Lys Ser Lys Ile Cys Ser Glu Arg Lys 
            820                 825                 830         


Arg Val Asn Glu Asn Glu Leu Gln Gln Asp Glu Pro Pro Ala Lys Lys 
        835                 840                 845             


Gly Ser Ile His Val Ser Ser Ala Ile Thr Glu Asp Gln Lys Lys Ser 
    850                 855                 860                 


Glu Glu Val Arg Pro Asn Ile Ala Glu Ile Glu Asp Ile Arg Val Leu 
865                 870                 875                 880 


Gln Glu Asn Asn Glu Gly Leu Arg Ala Phe Leu Leu Thr Ile Glu Asn 
                885                 890                 895     


Glu Leu Lys Asn Glu Lys Glu Glu Lys Ala Glu Leu Asn Lys Gln Ile 
            900                 905                 910         


Val His Phe Gln Gln Glu Leu Ser Leu Ser Glu Lys Lys Asn Leu Thr 
        915                 920                 925             


Leu Ser Lys Glu Val Gln Gln Ile Gln Ser Asn Tyr Asp Ile Ala Ile 
    930                 935                 940                 


Ala Glu Leu His Val Gln Lys Ser Lys Asn Gln Glu Gln Glu Glu Lys 
945                 950                 955                 960 


Ile Met Lys Leu Ser Asn Glu Ile Glu Thr Ala Thr Arg Ser Ile Thr 
                965                 970                 975     


Asn Asn Val Ser Gln Ile Lys Leu Met His Thr Lys Ile Asp Glu Leu 
            980                 985                 990         


Arg Thr Leu Asp Ser Val Ser Gln  Ile Ser Asn Ile Asp  Leu Leu Asn 
        995                 1000                 1005             


Leu Arg  Asp Leu Ser Asn Gly  Ser Glu Glu Asp Asn  Leu Pro Asn 
    1010                 1015                 1020             


Thr Gln  Leu Asp Leu Leu Gly  Asn Asp Tyr Leu Val  Ser Lys Gln 
    1025                 1030                 1035             


Val Lys  Glu Tyr Arg Ile Gln  Glu Pro Asn Arg Glu  Asn Ser Phe 
    1040                 1045                 1050             


His Ser  Ser Ile Glu Ala Ile  Trp Glu Glu Cys Lys  Glu Ile Val 
    1055                 1060                 1065             


Lys Ala  Ser Ser Lys Lys Ser  His Gln Ile Glu Glu  Leu Glu Gln 
    1070                 1075                 1080             


Gln Ile  Glu Lys Leu Gln Ala  Glu Val Lys Gly Tyr  Lys Asp Glu 
    1085                 1090                 1095             


Asn Asn  Arg Leu Lys Glu Lys  Glu His Lys Asn Gln  Asp Asp Leu 
    1100                 1105                 1110             


Leu Lys  Glu Lys Glu Thr Leu  Ile Gln Gln Leu Lys  Glu Glu Leu 
    1115                 1120                 1125             


Gln Glu  Lys Asn Val Thr Leu  Asp Val Gln Ile Gln  His Val Val 
    1130                 1135                 1140             


Glu Gly  Lys Arg Ala Leu Ser  Glu Leu Thr Gln Gly  Val Thr Cys 
    1145                 1150                 1155             


Tyr Lys  Ala Lys Ile Lys Glu  Leu Glu Thr Ile Leu  Glu Thr Gln 
    1160                 1165                 1170             


Lys Val  Glu Cys Ser His Ser  Ala Lys Leu Glu Gln  Asp Ile Leu 
    1175                 1180                 1185             


Glu Lys  Glu Ser Ile Ile Leu  Lys Leu Glu Arg Asn  Leu Lys Glu 
    1190                 1195                 1200             


Phe Gln  Glu His Leu Gln Asp  Ser Val Lys Asn Thr  Lys Asp Leu 
    1205                 1210                 1215             


Asn Val  Lys Glu Leu Lys Leu  Lys Glu Glu Ile Thr  Gln Leu Thr 
    1220                 1225                 1230             


Asn Asn  Leu Gln Asp Met Lys  His Leu Leu Gln Leu  Lys Glu Glu 
    1235                 1240                 1245             


Glu Glu  Glu Thr Asn Arg Gln  Glu Thr Glu Lys Leu  Lys Glu Glu 
    1250                 1255                 1260             


Leu Ser  Ala Ser Ser Ala Arg  Thr Gln Asn Leu Lys  Ala Asp Leu 
    1265                 1270                 1275             


Gln Arg  Lys Glu Glu Asp Tyr  Ala Asp Leu Lys Glu  Lys Leu Thr 
    1280                 1285                 1290             


Asp Ala  Lys Lys Gln Ile Lys  Gln Val Gln Lys Glu  Val Ser Val 
    1295                 1300                 1305             


Met Arg  Asp Glu Asp Lys Leu  Leu Arg Ile Lys Ile  Asn Glu Leu 
    1310                 1315                 1320             


Glu Lys  Lys Lys Asn Gln Cys  Ser Gln Glu Leu Asp  Met Lys Gln 
    1325                 1330                 1335             


Arg Thr  Ile Gln Gln Leu Lys  Glu Gln Leu Asn Asn  Gln Lys Val 
    1340                 1345                 1350             


Glu Glu  Ala Ile Gln Gln Tyr  Glu Arg Ala Cys Lys  Asp Leu Asn 
    1355                 1360                 1365             


Val Lys  Glu Lys Ile Ile Glu  Asp Met Arg Met Thr  Leu Glu Glu 
    1370                 1375                 1380             


Gln Glu  Gln Thr Gln Val Glu  Gln Asp Gln Val Leu  Glu Ala Lys 
    1385                 1390                 1395             


Leu Glu  Glu Val Glu Arg Leu  Ala Thr Glu Leu Glu  Lys Trp Lys 
    1400                 1405                 1410             


Glu Lys  Cys Asn Asp Leu Glu  Thr Lys Asn Asn Gln  Arg Ser Asn 
    1415                 1420                 1425             


Lys Glu  His Glu Asn Asn Thr  Asp Val Leu Gly Lys  Leu Thr Asn 
    1430                 1435                 1440             


Leu Gln  Asp Glu Leu Gln Glu  Ser Glu Gln Lys Tyr  Asn Ala Asp 
    1445                 1450                 1455             


Arg Lys  Lys Trp Leu Glu Glu  Lys Met Met Leu Ile  Thr Gln Ala 
    1460                 1465                 1470             


Lys Glu  Ala Glu Asn Ile Arg  Asn Lys Glu Met Lys  Lys Tyr Ala 
    1475                 1480                 1485             


Glu Asp  Arg Glu Arg Phe Phe  Lys Gln Gln Asn Glu  Met Glu Ile 
    1490                 1495                 1500             


Leu Thr  Ala Gln Leu Thr Glu  Lys Asp Ser Asp Leu  Gln Lys Trp 
    1505                 1510                 1515             


Arg Glu  Glu Arg Asp Gln Leu  Val Ala Ala Leu Glu  Ile Gln Leu 
    1520                 1525                 1530             


Lys Ala  Leu Ile Ser Ser Asn  Val Gln Lys Asp Asn  Glu Ile Glu 
    1535                 1540                 1545             


Gln Leu  Lys Arg Ile Ile Ser  Glu Thr Ser Lys Ile  Glu Thr Gln 
    1550                 1555                 1560             


Ile Met  Asp Ile Lys Pro Lys  Arg Ile Ser Ser Ala  Asp Pro Asp 
    1565                 1570                 1575             


Lys Leu  Gln Thr Glu Pro Leu  Ser Thr Ser Phe Glu  Ile Ser Arg 
    1580                 1585                 1590             


Asn Lys  Ile Glu Asp Gly Ser  Val Val Leu Asp Ser  Cys Glu Val 
    1595                 1600                 1605             


Ser Thr  Glu Asn Asp Gln Ser  Thr Arg Phe Pro Lys  Pro Glu Leu 
    1610                 1615                 1620             


Glu Ile  Gln Phe Thr Pro Leu  Gln Pro Asn Lys Met  Ala Val Lys 
    1625                 1630                 1635             


His Pro  Gly Cys Thr Thr Pro  Val Thr Val Lys Ile  Pro Lys Ala 
    1640                 1645                 1650             


Arg Lys  Arg Lys Ser Asn Glu  Met Glu Glu Ser Ala  Ser Pro Pro 
    1655                 1660                 1665             


Pro Lys  Glu Cys Ser Ser Ser  Pro Ala Met Glu Gln  Ser Trp Lys 
    1670                 1675                 1680             


Glu Asn  Asp Phe Asp Lys Leu  Arg Glu Glu Gly Phe  Arg Arg Ser 
    1685                 1690                 1695             


Asn Tyr  Ser Glu Leu Gln Glu  Glu Ile Gln Thr Lys  Gly Lys Glu 
    1700                 1705                 1710             


Val Glu  Asn Phe Glu Lys Asn  Leu Asp 
    1715                 1720         


<210> 6859
<211> 404
<212> PRT
<213> Homo sapiens

<400> 6859
Met Arg Arg Asp Val Asn Gly Val Thr Lys Ser Arg Phe Glu Met Phe 
1               5                   10                  15      


Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro Lys Glu Leu 
            20                  25                  30          


Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu Cys Arg Cys 
        35                  40                  45              


Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile Glu Gly Arg 
65                  70                  75                  80  


Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu Arg Lys Leu 
                85                  90                  95      


Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu Arg Thr Phe 
            100                 105                 110         


Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn Gly Cys Thr 
        115                 120                 125             


Lys Thr Thr Asp Ala Glu Gly Cys Pro Leu Leu Glu Gln Leu Asn Ile 
    130                 135                 140                 


Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala Leu Val Arg 
145                 150                 155                 160 


Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys Thr Gln Leu 
                165                 170                 175     


Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro Glu Leu Val 
            180                 185                 190         


Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu Gly Leu Ile 
        195                 200                 205             


Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys Ala Ser Gly 
    210                 215                 220                 


Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly Gln Asn Cys 
225                 230                 235                 240 


Pro Arg Leu Arg Ile Leu Glu Val Ala Arg Cys Ser Gln Leu Thr Asp 
                245                 250                 255     


Val Gly Phe Thr Thr Leu Ala Arg Asn Cys His Glu Leu Glu Lys Met 
            260                 265                 270         


Asp Leu Glu Glu Cys Val Gln Ile Thr Asp Ser Thr Leu Ile Gln Leu 
        275                 280                 285             


Ser Ile His Cys Pro Arg Leu Gln Val Leu Ser Leu Ser His Cys Glu 
    290                 295                 300                 


Leu Ile Thr Asp Asp Gly Ile Arg His Leu Gly Asn Gly Ala Cys Ala 
305                 310                 315                 320 


His Asp Gln Leu Glu Val Ile Glu Leu Asp Asn Cys Pro Leu Ile Thr 
                325                 330                 335     


Asp Ala Ser Leu Glu His Leu Lys Ser Cys His Ser Leu Glu Arg Ile 
            340                 345                 350         


Glu Leu Tyr Asp Cys Gln Gln Ile Thr Arg Ala Gly Ile Lys Arg Leu 
        355                 360                 365             


Arg Thr His Leu Pro Asn Ile Lys Val His Ala Tyr Phe Ala Pro Val 
    370                 375                 380                 


Thr Pro Pro Pro Ser Val Gly Gly Ser Arg Gln Arg Phe Cys Arg Cys 
385                 390                 395                 400 


Cys Ile Ile Leu 
                


<210> 6860
<211> 416
<212> PRT
<213> Homo sapiens

<400> 6860
Met Ala His Ser Pro Val Ala Val Gln Val Pro Gly Met Gln Asn Asn 
1               5                   10                  15      


Ile Ala Asp Pro Glu Glu Leu Phe Thr Lys Leu Glu Arg Ile Gly Lys 
            20                  25                  30          


Gly Ser Phe Gly Glu Val Phe Lys Gly Ile Asp Asn Arg Thr Gln Gln 
        35                  40                  45              


Val Val Ala Ile Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile 
    50                  55                  60                  


Glu Asp Ile Gln Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Ser 
65                  70                  75                  80  


Tyr Val Thr Lys Tyr Tyr Gly Ser Tyr Leu Lys Gly Ser Lys Leu Trp 
                85                  90                  95      


Ile Ile Met Glu Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Arg 
            100                 105                 110         


Ala Gly Pro Phe Asp Glu Phe Gln Ile Ala Thr Met Leu Lys Glu Ile 
        115                 120                 125             


Leu Lys Gly Leu Asp Tyr Leu His Ser Glu Lys Lys Ile His Arg Asp 
    130                 135                 140                 


Ile Lys Ala Ala Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu 
145                 150                 155                 160 


Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg 
                165                 170                 175     


Asn Thr Phe Val Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Gln 
            180                 185                 190         


Gln Ser Ala Tyr Asp Ser Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr 
        195                 200                 205             


Ala Ile Glu Leu Ala Lys Gly Glu Pro Pro Asn Ser Asp Met His Pro 
    210                 215                 220                 


Met Arg Val Leu Phe Leu Ile Pro Lys Asn Asn Pro Pro Thr Leu Val 
225                 230                 235                 240 


Gly Asp Phe Thr Lys Ser Phe Lys Glu Phe Ile Asp Ala Cys Leu Asn 
                245                 250                 255     


Lys Asp Pro Ser Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys 
            260                 265                 270         


Phe Ile Val Lys Asn Ser Lys Lys Thr Ser Tyr Leu Thr Glu Leu Ile 
        275                 280                 285             


Asp Arg Phe Lys Arg Trp Lys Ala Glu Gly His Ser Asp Asp Glu Ser 
    290                 295                 300                 


Asp Ser Glu Gly Ser Asp Ser Glu Ser Thr Ser Arg Glu Asn Asn Thr 
305                 310                 315                 320 


His Pro Glu Trp Ser Phe Thr Thr Val Arg Lys Lys Pro Asp Pro Lys 
                325                 330                 335     


Lys Val Gln Asn Gly Ala Glu Gln Asp Leu Val Gln Thr Leu Ser Cys 
            340                 345                 350         


Leu Ser Met Ile Ile Thr Pro Ala Phe Ala Glu Leu Lys Gln Gln Asp 
        355                 360                 365             


Glu Asn Asn Ala Ser Arg Asn Gln Ala Ile Glu Glu Leu Glu Lys Ser 
    370                 375                 380                 


Ile Ala Val Ala Glu Ala Ala Cys Pro Gly Ile Thr Asp Lys Met Val 
385                 390                 395                 400 


Lys Lys Leu Ile Glu Lys Phe Gln Lys Cys Ser Ala Asp Glu Ser Pro 
                405                 410                 415     


<210> 6861
<211> 339
<212> PRT
<213> Homo sapiens

<400> 6861
Met Ala His Ser Pro Val Ala Val Gln Val Pro Gly Met Gln Gly Ser 
1               5                   10                  15      


Lys Leu Trp Ile Ile Met Glu Tyr Leu Gly Gly Gly Ser Ala Leu Asp 
            20                  25                  30          


Leu Leu Arg Ala Gly Pro Phe Asp Glu Phe Gln Ile Ala Thr Met Leu 
        35                  40                  45              


Lys Glu Ile Leu Lys Gly Leu Asp Tyr Leu His Ser Glu Lys Lys Ile 
    50                  55                  60                  


His Arg Asp Ile Lys Ala Ala Asn Val Leu Leu Ser Glu Gln Gly Asp 
65                  70                  75                  80  


Val Lys Leu Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Gln 
                85                  90                  95      


Ile Lys Arg Asn Thr Phe Val Gly Thr Pro Phe Trp Met Ala Pro Glu 
            100                 105                 110         


Val Ile Gln Gln Ser Ala Tyr Asp Ser Lys Ala Asp Ile Trp Ser Leu 
        115                 120                 125             


Gly Ile Thr Ala Ile Glu Leu Ala Lys Gly Glu Pro Pro Asn Ser Asp 
    130                 135                 140                 


Met His Pro Met Arg Val Leu Phe Leu Ile Pro Lys Asn Asn Pro Pro 
145                 150                 155                 160 


Thr Leu Val Gly Asp Phe Thr Lys Ser Phe Lys Glu Phe Ile Asp Ala 
                165                 170                 175     


Cys Leu Asn Lys Asp Pro Ser Phe Arg Pro Thr Ala Lys Glu Leu Leu 
            180                 185                 190         


Lys His Lys Phe Ile Val Lys Asn Ser Lys Lys Thr Ser Tyr Leu Thr 
        195                 200                 205             


Glu Leu Ile Asp Arg Phe Lys Arg Trp Lys Ala Glu Gly His Ser Asp 
    210                 215                 220                 


Asp Glu Ser Asp Ser Glu Gly Ser Asp Ser Glu Ser Thr Ser Arg Glu 
225                 230                 235                 240 


Asn Asn Thr His Pro Glu Trp Ser Phe Thr Thr Val Arg Lys Lys Pro 
                245                 250                 255     


Asp Pro Lys Lys Val Gln Asn Gly Ala Glu Gln Asp Leu Val Gln Thr 
            260                 265                 270         


Leu Ser Cys Leu Ser Met Ile Ile Thr Pro Ala Phe Ala Glu Leu Lys 
        275                 280                 285             


Gln Gln Asp Glu Asn Asn Ala Ser Arg Asn Gln Ala Ile Glu Glu Leu 
    290                 295                 300                 


Glu Lys Ser Ile Ala Val Ala Glu Ala Ala Cys Pro Gly Ile Thr Asp 
305                 310                 315                 320 


Lys Met Val Lys Lys Leu Ile Glu Lys Phe Gln Lys Cys Ser Ala Asp 
                325                 330                 335     


Glu Ser Pro 
            


<210> 6862
<211> 874
<212> PRT
<213> Homo sapiens

<400> 6862
Met Glu Val Leu Arg Glu Lys Val Glu Glu Glu Glu Glu Ala Glu Arg 
1               5                   10                  15      


Glu Glu Ala Ala Glu Trp Ala Glu Trp Ala Arg Met Glu Lys Met Met 
            20                  25                  30          


Arg Pro Val Glu Val Arg Lys Glu Glu Ile Thr Leu Lys Gln Glu Thr 
        35                  40                  45              


Leu Arg Asp Leu Glu Lys Lys Leu Ser Glu Ile Gln Ile Thr Val Ser 
    50                  55                  60                  


Ala Glu Leu Pro Ala Phe Thr Lys Asp Thr Ile Asp Ile Ser Lys Leu 
65                  70                  75                  80  


Pro Ile Ser Tyr Lys Thr Asn Thr Pro Lys Glu Glu His Leu Leu Gln 
                85                  90                  95      


Val Ala Asp Asn Phe Ser Arg Gln Tyr Ser His Leu Cys Pro Asp Arg 
            100                 105                 110         


Val Pro Leu Phe Leu His Pro Leu Asn Glu Cys Glu Val Pro Lys Phe 
        115                 120                 125             


Val Ser Thr Thr Leu Arg Pro Thr Leu Met Pro Tyr Pro Glu Leu Tyr 
    130                 135                 140                 


Asn Trp Asp Ser Cys Ala Gln Phe Val Ser Asp Phe Leu Thr Met Val 
145                 150                 155                 160 


Pro Leu Pro Asp Pro Leu Lys Pro Pro Ser His Leu Tyr Ser Ser Thr 
                165                 170                 175     


Thr Val Leu Lys Tyr Gln Lys Gly Asn Cys Phe Asp Phe Ser Thr Leu 
            180                 185                 190         


Leu Cys Ser Met Leu Ile Gly Ser Gly Tyr Asp Ala Tyr Cys Val Asn 
        195                 200                 205             


Gly Tyr Gly Ser Leu Asp Leu Cys His Met Asp Leu Thr Arg Glu Val 
    210                 215                 220                 


Cys Pro Leu Thr Val Lys Pro Lys Glu Thr Ile Lys Lys Glu Glu Lys 
225                 230                 235                 240 


Val Leu Pro Lys Lys Tyr Thr Ile Lys Pro Pro Arg Asp Leu Cys Ser 
                245                 250                 255     


Arg Phe Glu Gln Glu Gln Glu Val Lys Lys Gln Gln Glu Ile Arg Ala 
            260                 265                 270         


Gln Glu Lys Lys Arg Leu Arg Glu Glu Glu Glu Arg Leu Met Glu Ala 
        275                 280                 285             


Glu Lys Ala Lys Pro Asp Ala Leu His Gly Leu Arg Val His Ser Trp 
    290                 295                 300                 


Val Leu Val Leu Ser Gly Lys Arg Glu Val Pro Glu Asn Phe Phe Ile 
305                 310                 315                 320 


Asp Pro Phe Thr Gly His Ser Tyr Ser Thr Gln Asp Glu His Phe Leu 
                325                 330                 335     


Gly Ile Glu Ser Leu Trp Asn His Lys Asn Tyr Trp Ile Asn Met Gln 
            340                 345                 350         


Asp Cys Trp Asn Cys Cys Lys Asp Leu Ile Phe Asp Leu Gly Asp Pro 
        355                 360                 365             


Val Arg Trp Glu Tyr Met Leu Leu Gly Thr Asp Lys Ser Gln Leu Ser 
    370                 375                 380                 


Leu Thr Glu Glu Asp Asp Ser Gly Ile Asn Asp Glu Asp Asp Val Glu 
385                 390                 395                 400 


Asn Leu Gly Lys Glu Asp Glu Asp Lys Ser Phe Asp Met Pro His Ser 
                405                 410                 415     


Trp Val Glu Gln Ile Glu Ile Ser Pro Glu Ala Phe Glu Thr Arg Cys 
            420                 425                 430         


Pro Asn Gly Lys Lys Val Ile Gln Tyr Lys Arg Ala Lys Leu Glu Lys 
        435                 440                 445             


Trp Ala Pro Tyr Leu Asn Ser Asn Gly Leu Val Ser Arg Leu Thr Thr 
    450                 455                 460                 


Tyr Glu Asp Leu Gln Cys Thr Asn Ile Leu Glu Ile Lys Glu Trp Tyr 
465                 470                 475                 480 


Gln Asn Arg Glu Asp Met Leu Glu Leu Lys His Ile Asn Lys Thr Thr 
                485                 490                 495     


Asp Leu Lys Thr Asp Tyr Phe Lys Pro Gly His Pro Gln Ala Leu Arg 
            500                 505                 510         


Val His Ser Tyr Lys Ser Met Gln Pro Glu Met Asp Arg Val Ile Glu 
        515                 520                 525             


Phe Tyr Glu Thr Ala Arg Val Asp Gly Leu Met Lys Arg Glu Glu Thr 
    530                 535                 540                 


Pro Arg Thr Met Thr Glu Tyr Tyr Gln Gly Arg Pro Asp Phe Leu Ser 
545                 550                 555                 560 


Tyr Arg His Ala Ser Phe Gly Pro Arg Val Lys Lys Leu Thr Leu Ser 
                565                 570                 575     


Ser Ala Glu Ser Asn Pro Arg Pro Ile Val Lys Ile Thr Glu Arg Phe 
            580                 585                 590         


Phe Arg Asn Pro Ala Lys Pro Ala Glu Glu Asp Val Ala Glu Arg Val 
        595                 600                 605             


Phe Leu Val Ala Glu Glu Arg Ile Gln Leu Arg Tyr His Cys Arg Glu 
    610                 615                 620                 


Asp His Ile Thr Ala Ser Lys Arg Glu Phe Leu Arg Arg Thr Glu Val 
625                 630                 635                 640 


Asp Ser Lys Gly Asn Lys Ile Ile Met Thr Pro Asp Met Cys Ile Ser 
                645                 650                 655     


Phe Glu Val Glu Pro Met Glu His Thr Lys Lys Leu Leu Tyr Gln Tyr 
            660                 665                 670         


Glu Ala Met Met His Leu Lys Arg Glu Glu Lys Leu Ser Arg His Gln 
        675                 680                 685             


Val Trp Glu Ser Glu Leu Glu Val Leu Glu Ile Leu Lys Leu Arg Glu 
    690                 695                 700                 


Glu Glu Glu Ala Ala His Thr Leu Thr Ile Ser Ile Tyr Asp Thr Lys 
705                 710                 715                 720 


Arg Asn Glu Lys Ser Lys Glu Tyr Arg Glu Ala Met Glu Arg Met Met 
                725                 730                 735     


His Glu Glu His Leu Arg Gln Val Glu Thr Gln Leu Asp Tyr Leu Ala 
            740                 745                 750         


Pro Phe Leu Ala Gln Leu Pro Pro Gly Glu Lys Leu Thr Cys Trp Gln 
        755                 760                 765             


Ala Val Arg Leu Lys Asp Glu Cys Leu Ser Asp Phe Lys Gln Arg Leu 
    770                 775                 780                 


Ile Asn Lys Ala Asn Leu Ile Gln Ala Arg Phe Glu Lys Glu Thr Gln 
785                 790                 795                 800 


Glu Leu Gln Lys Lys Gln Gln Trp Tyr Gln Glu Asn Gln Val Thr Leu 
                805                 810                 815     


Thr Pro Glu Asp Glu Asp Leu Tyr Leu Ser Tyr Cys Ser Gln Ala Met 
            820                 825                 830         


Phe Arg Ile Arg Ile Leu Glu Gln Arg Leu Asn Arg His Lys Glu Leu 
        835                 840                 845             


Ala Pro Leu Lys Tyr Leu Ala Leu Glu Glu Lys Leu Tyr Lys Asp Pro 
    850                 855                 860                 


Arg Leu Gly Glu Leu Gln Lys Ile Phe Ala 
865                 870                 


<210> 6863
<211> 482
<212> PRT
<213> Homo sapiens

<400> 6863
Met Glu Gln Ser Asn Leu Glu Lys Leu Glu Leu Asn Val Arg Lys Leu 
1               5                   10                  15      


Gln Gln Glu Leu Asp Gln Leu Asn Arg Asp Lys Leu Ser Leu His Asn 
            20                  25                  30          


Asp Ile Ser Ala Met Gln Gln Gln Leu Gln Glu Lys Arg Glu Ala Val 
        35                  40                  45              


Asn Ser Leu Gln Glu Glu Leu Ala Asn Val Gln Asp His Leu Asn Leu 
    50                  55                  60                  


Ala Lys Gln Asp Leu Leu His Thr Thr Lys His Gln Asp Val Leu Leu 
65                  70                  75                  80  


Ser Glu Gln Thr Arg Leu Gln Lys Asp Ile Ser Glu Trp Ala Asn Arg 
                85                  90                  95      


Phe Glu Asp Cys Gln Lys Glu Glu Glu Thr Lys Gln Gln Gln Leu Gln 
            100                 105                 110         


Val Leu Gln Asn Glu Ile Glu Glu Asn Lys Leu Lys Leu Val Gln Gln 
        115                 120                 125             


Glu Met Met Phe Gln Arg Leu Gln Lys Glu Arg Glu Ser Glu Lys Ser 
    130                 135                 140                 


Lys Leu Asp Gln Val Leu Ser Lys Val Leu Ala Ala Glu Glu Arg Val 
145                 150                 155                 160 


Arg Thr Leu Gln Glu Glu Glu Arg Trp Cys Glu Ser Leu Glu Lys Thr 
                165                 170                 175     


Leu Ser Gln Thr Lys Arg Gln Leu Ser Glu Arg Glu Gln Gln Leu Val 
            180                 185                 190         


Glu Lys Ser Gly Glu Leu Leu Ala Leu Gln Lys Glu Ala Asp Ser Met 
        195                 200                 205             


Arg Ala Asp Phe Ser Leu Leu Arg Asn Gln Phe Leu Thr Glu Arg Lys 
    210                 215                 220                 


Lys Ala Glu Lys Gln Val Ala Ser Leu Lys Glu Ala Leu Lys Ile Gln 
225                 230                 235                 240 


Arg Ser Gln Leu Glu Lys Asn Leu Leu Glu Gln Lys Gln Glu Asn Ser 
                245                 250                 255     


Cys Ile Gln Lys Glu Met Ala Thr Ile Glu Leu Val Ala Gln Asp Asn 
            260                 265                 270         


His Glu Arg Ala Arg Arg Leu Met Lys Glu Leu Asn Gln Met Gln Tyr 
        275                 280                 285             


Glu Tyr Thr Glu Leu Lys Lys Gln Met Ala Asn Gln Lys Asp Leu Glu 
    290                 295                 300                 


Arg Arg Gln Met Glu Ile Ser Asp Ala Met Arg Thr Leu Lys Ser Glu 
305                 310                 315                 320 


Val Lys Asp Glu Ile Arg Thr Ser Leu Lys Asn Leu Asn Gln Phe Leu 
                325                 330                 335     


Pro Glu Leu Pro Ala Asp Leu Glu Ala Ile Leu Glu Arg Asn Glu Asn 
            340                 345                 350         


Leu Glu Gly Glu Leu Glu Ser Leu Lys Glu Asn Leu Pro Phe Thr Met 
        355                 360                 365             


Asn Glu Gly Pro Phe Glu Glu Lys Leu Asn Phe Ser Gln Val His Ile 
    370                 375                 380                 


Met Asp Glu His Trp Arg Gly Glu Ala Leu Arg Glu Lys Leu Arg His 
385                 390                 395                 400 


Arg Glu Asp Arg Leu Lys Ala Gln Leu Arg His Cys Met Ser Lys Gln 
                405                 410                 415     


Ala Glu Val Leu Ile Lys Gly Lys Arg Gln Thr Glu Gly Thr Leu His 
            420                 425                 430         


Ser Leu Arg Arg Gln Val Asp Ala Leu Gly Glu Leu Val Thr Ser Thr 
        435                 440                 445             


Ser Ala Asp Ser Ala Ser Ser Pro Ser Leu Ser Gln Leu Glu Ser Ser 
    450                 455                 460                 


Leu Thr Glu Asp Ser Gln Leu Gly Gln Asn Gln Glu Lys Asn Ala Ser 
465                 470                 475                 480 


Ala Arg 
        


<210> 6864
<211> 1259
<212> PRT
<213> Homo sapiens

<400> 6864
Met Ala Leu Arg Pro Gly Ala Gly Ser Gly Gly Gly Gly Ala Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ser Ala Gly Gly Gly Gly Phe Met Phe Pro Val Ala 
            20                  25                  30          


Gly Gly Ile Arg Pro Pro Gln Ala Gly Leu Met Pro Met Gln Gln Gln 
        35                  40                  45              


Gly Phe Pro Met Val Ser Val Met Gln Pro Asn Met Gln Gly Ile Met 
    50                  55                  60                  


Gly Met Asn Tyr Ser Ser Gln Met Ser Gln Gly Pro Ile Ala Met Gln 
65                  70                  75                  80  


Ala Gly Ile Pro Met Gly Pro Met Pro Ala Ala Gly Met Pro Tyr Leu 
                85                  90                  95      


Gly Gln Ala Pro Phe Leu Gly Met Arg Pro Pro Gly Pro Gln Tyr Thr 
            100                 105                 110         


Pro Asp Met Gln Lys Gln Phe Ala Glu Glu Gln Gln Lys Arg Phe Glu 
        115                 120                 125             


Gln Gln Gln Lys Leu Leu Glu Glu Glu Arg Lys Arg Arg Gln Phe Glu 
    130                 135                 140                 


Glu Gln Lys Gln Lys Leu Arg Leu Leu Ser Ser Val Lys Pro Lys Thr 
145                 150                 155                 160 


Gly Glu Lys Ser Arg Asp Asp Ala Leu Glu Ala Ile Lys Gly Asn Leu 
                165                 170                 175     


Asp Gly Phe Ser Arg Asp Ala Lys Met His Pro Thr Pro Ala Ser His 
            180                 185                 190         


Pro Lys Lys Pro Gly Val Gly Val Phe Pro Ser Gln Asp Pro Ala Gln 
        195                 200                 205             


Pro Arg Met Pro Pro Trp Ile Tyr Asn Glu Ser Leu Val Pro Asp Ala 
    210                 215                 220                 


Tyr Lys Lys Ile Leu Glu Thr Thr Met Thr Pro Thr Gly Ile Asp Thr 
225                 230                 235                 240 


Ala Lys Leu Tyr Pro Ile Leu Met Ser Ser Gly Leu Pro Arg Glu Thr 
                245                 250                 255     


Leu Gly Gln Ile Trp Ala Leu Ala Asn Arg Thr Thr Pro Gly Lys Leu 
            260                 265                 270         


Thr Lys Glu Glu Leu Tyr Thr Val Leu Ala Met Ile Ala Val Thr Gln 
        275                 280                 285             


Arg Gly Val Pro Ala Met Ser Pro Asp Ala Leu Asn Gln Phe Pro Ala 
    290                 295                 300                 


Ala Pro Ile Pro Thr Leu Ser Gly Phe Ser Met Thr Leu Pro Thr Pro 
305                 310                 315                 320 


Val Ser Gln Pro Thr Val Ile Pro Ser Gly Pro Ala Gly Ser Met Pro 
                325                 330                 335     


Leu Ser Leu Gly Gln Pro Val Met Gly Ile Asn Leu Val Gly Pro Val 
            340                 345                 350         


Gly Gly Ala Ala Ala Gln Ala Ser Ser Gly Phe Ile Pro Thr Tyr Pro 
        355                 360                 365             


Ala Asn Gln Val Val Lys Pro Glu Glu Asp Asp Phe Gln Asp Phe Gln 
    370                 375                 380                 


Asp Ala Ser Lys Ser Gly Ser Leu Asp Asp Ser Phe Ser Asp Phe Gln 
385                 390                 395                 400 


Glu Leu Pro Ala Ser Ser Lys Thr Ser Asn Ser Gln His Gly Asn Ser 
                405                 410                 415     


Ala Pro Ser Leu Leu Met Pro Leu Pro Gly Thr Lys Ala Leu Pro Ser 
            420                 425                 430         


Met Asp Lys Tyr Ala Val Phe Lys Gly Ile Ala Ala Asp Lys Ser Ser 
        435                 440                 445             


Glu Asn Thr Val Pro Pro Gly Asp Pro Gly Asp Lys Tyr Ser Ala Phe 
    450                 455                 460                 


Arg Glu Leu Glu Gln Thr Ala Glu Asn Lys Pro Leu Gly Glu Ser Phe 
465                 470                 475                 480 


Ala Glu Phe Arg Ser Ala Gly Thr Asp Asp Gly Phe Thr Asp Phe Lys 
                485                 490                 495     


Thr Ala Asp Ser Val Ser Pro Leu Glu Pro Pro Thr Lys Asp Lys Thr 
            500                 505                 510         


Phe Pro Pro Ser Phe Pro Ser Gly Thr Ile Gln Gln Lys Gln Gln Thr 
        515                 520                 525             


Gln Val Lys Asn Pro Leu Asn Leu Ala Asp Leu Asp Met Phe Ser Ser 
    530                 535                 540                 


Val Asn Cys Ser Ser Glu Lys Pro Leu Ser Phe Ser Ala Val Phe Ser 
545                 550                 555                 560 


Thr Ser Lys Ser Val Ser Thr Pro Gln Ser Thr Gly Ser Ala Ala Thr 
                565                 570                 575     


Met Thr Ala Leu Ala Ala Thr Lys Thr Ser Ser Leu Ala Asp Asp Phe 
            580                 585                 590         


Gly Glu Phe Ser Leu Phe Gly Glu Tyr Ser Gly Leu Ala Pro Val Gly 
        595                 600                 605             


Glu Gln Asp Asp Phe Ala Asp Phe Met Ala Phe Ser Asn Ser Ser Ile 
    610                 615                 620                 


Ser Ser Glu Gln Lys Pro Asp Asp Lys Tyr Asp Ala Leu Lys Glu Glu 
625                 630                 635                 640 


Ala Ser Pro Val Pro Leu Thr Ser Asn Val Gly Ser Thr Val Lys Gly 
                645                 650                 655     


Gly Gln Asn Ser Thr Ala Ala Ser Thr Lys Tyr Asp Val Phe Arg Gln 
            660                 665                 670         


Leu Ser Leu Glu Gly Ser Gly Leu Gly Val Glu Asp Leu Lys Asp Asn 
        675                 680                 685             


Thr Pro Ser Gly Lys Ser Asp Asp Asp Phe Ala Asp Phe His Ser Ser 
    690                 695                 700                 


Lys Phe Ser Ser Ile Asn Ser Asp Lys Ser Leu Gly Glu Lys Ala Val 
705                 710                 715                 720 


Ala Phe Arg His Thr Lys Glu Asp Ser Ala Ser Val Lys Ser Leu Asp 
                725                 730                 735     


Leu Pro Ser Ile Gly Gly Ser Ser Val Gly Lys Glu Asp Ser Glu Asp 
            740                 745                 750         


Ala Leu Ser Val Gln Phe Asp Met Lys Leu Ala Asp Val Gly Gly Asp 
        755                 760                 765             


Leu Lys His Val Met Ser Asp Ser Ser Leu Asp Leu Pro Thr Val Ser 
    770                 775                 780                 


Gly Gln His Pro Pro Ala Ala Asp Ile Glu Asp Leu Lys Tyr Ala Ala 
785                 790                 795                 800 


Phe Gly Ser Tyr Ser Ser Asn Phe Ala Val Ser Thr Leu Thr Ser Tyr 
                805                 810                 815     


Asp Trp Ser Asp Arg Asp Asp Ala Thr Gln Gly Arg Lys Leu Ser Pro 
            820                 825                 830         


Phe Val Leu Ser Ala Gly Ser Gly Ser Pro Ser Ala Thr Ser Ile Leu 
        835                 840                 845             


Gln Lys Lys Glu Thr Ser Phe Gly Ser Ser Glu Asn Ile Thr Met Thr 
    850                 855                 860                 


Ser Leu Ser Lys Val Thr Thr Phe Val Ser Glu Asp Ala Leu Pro Glu 
865                 870                 875                 880 


Thr Thr Phe Pro Ala Leu Ala Ser Phe Lys Asp Thr Ile Pro Gln Thr 
                885                 890                 895     


Ser Glu Gln Lys Glu Tyr Glu Asn Arg Asp Tyr Lys Asp Phe Thr Lys 
            900                 905                 910         


Gln Asp Leu Pro Thr Ala Glu Arg Ser Gln Glu Ala Thr Cys Pro Ser 
        915                 920                 925             


Pro Ala Ser Ser Gly Ala Ser Gln Glu Thr Pro Asn Glu Cys Ser Asp 
    930                 935                 940                 


Asp Phe Gly Glu Phe Gln Ser Glu Lys Pro Lys Ile Ser Lys Phe Asp 
945                 950                 955                 960 


Phe Leu Val Ala Thr Ser Gln Ser Lys Met Lys Ser Ser Glu Glu Met 
                965                 970                 975     


Ile Lys Ser Glu Leu Ala Thr Phe Asp Leu Ser Val Gln Gly Ser His 
            980                 985                 990         


Lys Arg Ser Leu Ser Leu Gly Asp  Lys Glu Ile Ser Arg  Ser Ser Pro 
        995                 1000                 1005             


Ser Pro  Ala Leu Glu Gln Pro  Phe Arg Asp Arg Ser  Asn Thr Leu 
    1010                 1015                 1020             


Asn Glu  Lys Pro Ala Leu Pro  Val Ile Arg Asp Lys  Tyr Lys Asp 
    1025                 1030                 1035             


Leu Thr  Gly Glu Val Glu Glu  Asn Glu Arg Tyr Ala  Tyr Glu Trp 
    1040                 1045                 1050             


Gln Arg  Cys Leu Gly Ser Ala  Leu Asn Val Ile Lys  Lys Ala Asn 
    1055                 1060                 1065             


Asp Thr  Leu Asn Gly Ile Ser  Ser Ser Ser Val Cys  Thr Glu Val 
    1070                 1075                 1080             


Ile Gln  Ser Ala Gln Gly Met  Glu Tyr Leu Leu Gly  Val Val Glu 
    1085                 1090                 1095             


Val Tyr  Arg Val Thr Lys Arg  Val Glu Leu Gly Ile  Lys Ala Thr 
    1100                 1105                 1110             


Ala Val  Cys Ser Glu Lys Leu  Gln Gln Leu Leu Lys  Asp Ile Asp 
    1115                 1120                 1125             


Lys Val  Trp Asn Asn Leu Ile  Gly Phe Met Ser Leu  Ala Thr Leu 
    1130                 1135                 1140             


Thr Cys  Cys Trp Glu Lys Met  Thr Val Ile Thr Lys  His Leu Ser 
    1145                 1150                 1155             


Pro Tyr  His Glu Leu Leu Glu  Glu Lys Pro Asp Glu  Asn Ser Leu 
    1160                 1165                 1170             


Asp Phe  Ser Ser Cys Met Leu  Arg Pro Gly Ile Lys  Asn Ala Gln 
    1175                 1180                 1185             


Glu Leu  Ala Cys Gly Val Cys  Leu Leu Asn Val Asp  Ser Arg Ser 
    1190                 1195                 1200             


Arg Lys  Glu Glu Lys Pro Ala  Glu Glu His Pro Lys  Lys Ala Phe 
    1205                 1210                 1215             


Asn Ser  Glu Thr Asp Ser Phe  Lys Leu Ala Tyr Gly  Gly His Gln 
    1220                 1225                 1230             


Tyr His  Ala Ser Cys Ala Asn  Phe Trp Ile Asn Cys  Val Glu Pro 
    1235                 1240                 1245             


Lys Pro  Pro Gly Leu Val Leu  Pro Asp Leu Leu 
    1250                 1255                 


<210> 6865
<211> 385
<212> PRT
<213> Homo sapiens

<400> 6865
Met Ala Leu Arg Pro Gly Ala Gly Ser Gly Gly Gly Gly Ala Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ser Ala Gly Gly Gly Gly Phe Met Phe Pro Val Ala 
            20                  25                  30          


Gly Gly Ile Arg Pro Pro Gln Ala Gly Leu Met Pro Met Gln Gln Gln 
        35                  40                  45              


Gly Phe Pro Met Val Ser Val Met Gln Pro Asn Met Gln Gly Ile Met 
    50                  55                  60                  


Gly Met Asn Tyr Ser Ser Gln Met Ser Gln Gly Pro Ile Ala Met Gln 
65                  70                  75                  80  


Ala Gly Ile Pro Met Gly Pro Met Pro Ala Ala Gly Met Pro Tyr Leu 
                85                  90                  95      


Gly Gln Ala Pro Phe Leu Gly Met Arg Pro Pro Gly Pro Gln Tyr Thr 
            100                 105                 110         


Pro Asp Met Gln Lys Gln Phe Ala Glu Glu Gln Gln Lys Arg Phe Glu 
        115                 120                 125             


Gln Gln Gln Lys Leu Leu Glu Glu Glu Arg Lys Arg Arg Gln Phe Glu 
    130                 135                 140                 


Glu Gln Lys Gln Lys Leu Arg Leu Leu Ser Ser Val Lys Pro Lys Thr 
145                 150                 155                 160 


Gly Glu Lys Ser Arg Asp Asp Ala Leu Glu Ala Ile Lys Gly Asn Leu 
                165                 170                 175     


Asp Gly Phe Ser Arg Asp Ala Lys Met His Pro Thr Pro Ala Ser His 
            180                 185                 190         


Pro Lys Lys Pro Asp Cys Pro Thr Ser Ser His Ser Thr Lys Thr Val 
        195                 200                 205             


Ser Pro Ser Pro Ala Phe Leu Asp Glu Glu Glu Phe Ser Asp Phe Met 
    210                 215                 220                 


Gln Gly Pro Val Glu Val Pro Pro Cys Gly Pro Ser Ser Thr Ser Gln 
225                 230                 235                 240 


Pro Phe Gln Ser Phe His Pro Ser Thr Pro Leu Gly Gln Leu His Thr 
                245                 250                 255     


Gln Lys Ala Gly Thr Gln Pro Leu Pro Pro Ser Gln Ser Pro Val Pro 
            260                 265                 270         


Phe Ala Leu His Gly Val Pro Gly Gln Ile Pro Tyr Phe Ser Thr Ala 
        275                 280                 285             


Ser Ala Ser His Ser Val Pro Glu Ala Gly Pro Ser Leu Glu Glu Lys 
    290                 295                 300                 


Phe Leu Val Ser Cys Asp Ile Ser Thr Ser Gly Gln Glu Gln Ile Lys 
305                 310                 315                 320 


Leu Asn Thr Ser Glu Val Gly His Lys Ala Leu Gly Pro Gly Ser Ser 
                325                 330                 335     


Lys Lys Tyr Pro Ser Leu Met Ala Ser Asn Gly Val Ala Val Asp Gly 
            340                 345                 350         


Cys Val Trp Glu Tyr Phe Pro His Arg Ile Leu Leu Ser Pro Glu Cys 
        355                 360                 365             


Leu Leu Gly Phe Thr Met Arg Val Trp Phe Gln Met Pro Ile Arg Lys 
    370                 375                 380                 


Ser 
385 


<210> 6866
<211> 312
<212> PRT
<213> Homo sapiens

<400> 6866
Met Ala Asp Phe Gly Ile Ser Ala Gly Gln Phe Val Ala Val Val Trp 
1               5                   10                  15      


Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu 
            20                  25                  30          


Gln Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn Ile Lys 
        35                  40                  45              


Gln Leu Leu Gln Ser Ala His Lys Glu Ser Ser Phe Asp Ile Ile Leu 
    50                  55                  60                  


Ser Gly Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala Glu Ile Leu 
65                  70                  75                  80  


Ala Glu Ile Ala Arg Ile Leu Arg Pro Gly Gly Cys Leu Phe Leu Lys 
                85                  90                  95      


Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val Lys Thr Ala 
            100                 105                 110         


Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val Glu Val Lys 
        115                 120                 125             


Glu Leu Gln Arg Glu Pro Leu Thr Pro Glu Glu Val Gln Ser Val Arg 
    130                 135                 140                 


Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val Gln Ile Thr 
145                 150                 155                 160 


Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gln Leu Lys Leu 
                165                 170                 175     


Ser Ile Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala Val Asp Pro 
            180                 185                 190         


Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met Glu Asp Asp 
        195                 200                 205             


Ser Met Asp Leu Ile Asp Ser Asp Glu Leu Leu Asp Pro Glu Asp Leu 
    210                 215                 220                 


Lys Lys Pro Asp Pro Ala Ser Leu Arg Ala Ala Ser Cys Gly Glu Gly 
225                 230                 235                 240 


Lys Lys Arg Lys Ala Cys Lys Asn Cys Thr Cys Gly Leu Ala Glu Glu 
                245                 250                 255     


Leu Glu Lys Glu Lys Ser Arg Glu Gln Met Ser Ser Gln Pro Lys Ser 
            260                 265                 270         


Ala Cys Gly Asn Cys Tyr Leu Gly Asp Ala Phe Arg Cys Ala Ser Cys 
        275                 280                 285             


Pro Tyr Leu Gly Met Pro Ala Phe Lys Pro Gly Glu Lys Val Leu Leu 
    290                 295                 300                 


Ser Asp Ser Asn Leu His Asp Ala 
305                 310         


<210> 6867
<211> 351
<212> PRT
<213> Homo sapiens

<400> 6867
Met Asn Glu Ser Asn Asp Ser Thr Asn Tyr Asp Met Ala Pro Tyr Tyr 
1               5                   10                  15      


Glu Ala Leu Cys Lys Ser Leu Asp Trp Gln Ile Asp Val Asp Leu Leu 
            20                  25                  30          


Asn Lys Met Lys Lys Ala Asn Glu Asp Glu Leu Lys Arg Leu Asp Glu 
        35                  40                  45              


Glu Leu Glu Asp Ala Glu Lys Asn Leu Gly Glu Ser Glu Ile Arg Asp 
    50                  55                  60                  


Ala Met Met Ala Lys Ala Glu Tyr Leu Cys Arg Ile Gly Asp Lys Glu 
65                  70                  75                  80  


Gly Ala Leu Thr Ala Phe Arg Lys Thr Tyr Asp Lys Thr Val Ala Leu 
                85                  90                  95      


Gly His Arg Leu Asp Ile Val Phe Tyr Leu Leu Arg Ile Gly Leu Phe 
            100                 105                 110         


Tyr Met Asp Asn Asp Leu Ile Thr Arg Asn Thr Glu Lys Ala Lys Ser 
        115                 120                 125             


Leu Ile Glu Glu Gly Gly Asp Trp Asp Arg Arg Asn Arg Leu Lys Val 
    130                 135                 140                 


Tyr Gln Gly Leu Tyr Cys Val Ala Ile Arg Asp Phe Lys Gln Ala Ala 
145                 150                 155                 160 


Glu Leu Phe Leu Asp Thr Val Ser Thr Phe Thr Ser Tyr Glu Leu Met 
                165                 170                 175     


Asp Tyr Lys Thr Phe Val Thr Tyr Thr Val Tyr Val Ser Met Ile Ala 
            180                 185                 190         


Leu Glu Arg Pro Asp Leu Arg Glu Lys Val Ile Lys Gly Ala Glu Ile 
        195                 200                 205             


Leu Glu Val Leu His Ser Leu Pro Ala Val Arg Gln Tyr Leu Phe Ser 
    210                 215                 220                 


Leu Tyr Glu Cys Arg Tyr Ser Val Phe Phe Gln Ser Leu Ala Val Val 
225                 230                 235                 240 


Glu Gln Glu Met Lys Lys Asp Trp Leu Phe Ala Pro His Tyr Arg Tyr 
                245                 250                 255     


Tyr Val Arg Glu Met Arg Ile His Ala Tyr Ser Gln Leu Leu Glu Ser 
            260                 265                 270         


Tyr Arg Ser Leu Thr Leu Gly Tyr Met Ala Glu Ala Phe Gly Val Gly 
        275                 280                 285             


Val Glu Phe Ile Asp Gln Glu Leu Ser Arg Phe Ile Ala Ala Gly Arg 
    290                 295                 300                 


Leu His Cys Lys Ile Asp Lys Val Asn Glu Ile Val Glu Thr Asn Arg 
305                 310                 315                 320 


Pro Asp Ser Lys Asn Trp Gln Tyr Gln Glu Thr Ile Lys Lys Gly Asp 
                325                 330                 335     


Leu Leu Leu Asn Arg Val Gln Lys Leu Ser Arg Val Ile Asn Met 
            340                 345                 350     


<210> 6868
<211> 137
<212> PRT
<213> Homo sapiens

<400> 6868
Met Ile Leu Pro Thr Lys Ala Met Ala Thr Gln Glu Leu Thr Val Lys 
1               5                   10                  15      


Arg Lys Leu Ser Gly Asn Thr Leu Gln Val Gln Ala Ser Ser Pro Val 
            20                  25                  30          


Ala Leu Gly Val Arg Ile Pro Thr Val Ala Leu His Met Met Glu Leu 
        35                  40                  45              


Phe Asp Thr Thr Val Glu Gln Leu Tyr Ser Ile Phe Thr Val Lys Glu 
    50                  55                  60                  


Leu Thr Asn Lys Lys Ile Ile Met Lys Trp Arg Cys Gly Asn Trp Pro 
65                  70                  75                  80  


Glu Glu His Tyr Ala Met Val Ala Leu Asn Phe Val Pro Thr Leu Gly 
                85                  90                  95      


Gln Thr Glu Leu Gln Leu Lys Glu Phe Leu Ser Ile Cys Lys Glu Glu 
            100                 105                 110         


Asn Met Lys Phe Cys Trp Gln Lys Gln His Phe Glu Glu Ile Lys Gly 
        115                 120                 125             


Ser Leu Gln Leu Thr Pro Leu Asn Gly 
    130                 135         


<210> 6869
<211> 931
<212> PRT
<213> Homo sapiens

<400> 6869
Met Ala Glu Val Glu Ala Val Gln Leu Lys Glu Glu Gly Asn Arg His 
1               5                   10                  15      


Phe Gln Leu Gln Asp Tyr Lys Ala Ala Thr Asn Ser Tyr Ser Gln Ala 
            20                  25                  30          


Leu Lys Leu Thr Lys Asp Lys Ala Leu Leu Ala Thr Leu Tyr Arg Asn 
        35                  40                  45              


Arg Ala Ala Cys Gly Leu Lys Thr Glu Ser Tyr Val Gln Ala Ala Ser 
    50                  55                  60                  


Asp Ala Ser Arg Ala Ile Asp Ile Asn Ser Ser Asp Ile Lys Ala Leu 
65                  70                  75                  80  


Tyr Arg Arg Cys Gln Ala Leu Glu His Leu Gly Lys Leu Asp Gln Ala 
                85                  90                  95      


Phe Lys Asp Val Gln Arg Cys Ala Thr Leu Glu Pro Arg Asn Gln Asn 
            100                 105                 110         


Phe Gln Glu Met Leu Arg Arg Leu Asn Thr Ser Ile Gln Glu Lys Leu 
        115                 120                 125             


Arg Val Gln Phe Ser Thr Asp Ser Arg Val Gln Lys Met Phe Glu Ile 
    130                 135                 140                 


Leu Leu Asp Glu Asn Ser Glu Ala Asp Lys Arg Glu Lys Ala Ala Asn 
145                 150                 155                 160 


Asn Leu Ile Val Leu Gly Arg Glu Glu Ala Gly Ala Glu Lys Ile Phe 
                165                 170                 175     


Gln Asn Asn Gly Val Ala Leu Leu Leu Gln Leu Leu Asp Thr Lys Lys 
            180                 185                 190         


Pro Glu Leu Val Leu Ala Ala Val Arg Thr Leu Ser Gly Met Cys Ser 
        195                 200                 205             


Gly His Gln Ala Arg Ala Thr Val Ile Leu His Ala Val Arg Ile Asp 
    210                 215                 220                 


Arg Ile Cys Ser Leu Met Ala Val Glu Asn Glu Glu Met Ser Leu Ala 
225                 230                 235                 240 


Val Cys Asn Leu Leu Gln Ala Ile Ile Asp Ser Leu Ser Gly Glu Asp 
                245                 250                 255     


Lys Arg Glu His Arg Gly Lys Glu Glu Ala Leu Val Leu Asp Thr Lys 
            260                 265                 270         


Lys Asp Leu Lys Gln Ile Thr Ser His Leu Leu Asp Met Leu Val Ser 
        275                 280                 285             


Lys Lys Val Ser Gly Gln Gly Arg Asp Gln Ala Leu Asn Leu Leu Asn 
    290                 295                 300                 


Lys Asn Val Pro Arg Lys Asp Leu Ala Ile His Asp Asn Ser Arg Thr 
305                 310                 315                 320 


Ile Tyr Val Val Asp Asn Gly Leu Arg Lys Ile Leu Lys Val Val Gly 
                325                 330                 335     


Gln Val Pro Asp Leu Pro Ser Cys Leu Pro Leu Thr Asp Asn Thr Arg 
            340                 345                 350         


Met Leu Ala Ser Ile Leu Ile Asn Lys Leu Tyr Asp Asp Leu Arg Cys 
        355                 360                 365             


Asp Pro Glu Arg Asp His Phe Arg Lys Ile Cys Glu Glu Tyr Ile Thr 
    370                 375                 380                 


Gly Lys Phe Asp Pro Gln Asp Met Asp Lys Asn Leu Asn Ala Ile Gln 
385                 390                 395                 400 


Thr Val Ser Gly Ile Leu Gln Gly Pro Phe Asp Leu Gly Asn Gln Leu 
                405                 410                 415     


Leu Gly Leu Lys Gly Val Met Glu Met Met Val Ala Leu Cys Gly Ser 
            420                 425                 430         


Glu Arg Glu Thr Asp Gln Leu Val Ala Val Glu Ala Leu Ile His Ala 
        435                 440                 445             


Ser Thr Lys Leu Ser Arg Ala Thr Phe Ile Ile Thr Asn Gly Val Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ile Tyr Lys Thr Thr Lys Asn Glu Lys Ile Lys Ile 
465                 470                 475                 480 


Arg Thr Leu Val Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr Asp 
                485                 490                 495     


Tyr Gly Leu Arg Gln Phe Ala Glu Gly Ser Thr Glu Lys Leu Ala Lys 
            500                 505                 510         


Gln Cys Arg Lys Trp Leu Cys Asn Met Ser Ile Asp Thr Arg Thr Arg 
        515                 520                 525             


Arg Trp Ala Val Glu Gly Leu Ala Tyr Leu Thr Leu Asp Ala Asp Val 
    530                 535                 540                 


Lys Asp Asp Phe Val Gln Asp Val Pro Ala Leu Gln Ala Met Phe Glu 
545                 550                 555                 560 


Leu Ala Lys Ala Gly Thr Ser Asp Lys Thr Ile Leu Tyr Ser Val Ala 
                565                 570                 575     


Thr Thr Leu Val Asn Cys Thr Asn Ser Tyr Asp Val Lys Glu Val Ile 
            580                 585                 590         


Pro Glu Leu Val Gln Leu Ala Lys Phe Ser Lys Gln His Val Pro Glu 
        595                 600                 605             


Glu His Pro Lys Asp Lys Lys Asp Phe Ile Asp Met Arg Val Lys Arg 
    610                 615                 620                 


Leu Leu Lys Ala Gly Val Ile Ser Ala Leu Ala Cys Met Val Lys Ala 
625                 630                 635                 640 


Asp Ser Ala Ile Leu Thr Asp Gln Thr Lys Glu Leu Leu Ala Arg Val 
                645                 650                 655     


Phe Leu Ala Leu Cys Asp Asn Pro Lys Asp Arg Gly Thr Ile Val Ala 
            660                 665                 670         


Gln Gly Gly Gly Lys Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp 
        675                 680                 685             


Val Gly Lys Val Lys Ala Ala His Ala Leu Ala Lys Ile Ala Ala Val 
    690                 695                 700                 


Ser Asn Pro Asp Ile Ala Phe Pro Gly Glu Arg Val Tyr Glu Val Val 
705                 710                 715                 720 


Arg Pro Leu Val Arg Leu Leu Asp Thr Gln Arg Asp Gly Leu Gln Asn 
                725                 730                 735     


Tyr Glu Ala Leu Leu Gly Leu Thr Asn Leu Ser Gly Arg Ser Asp Lys 
            740                 745                 750         


Leu Arg Gln Lys Ile Phe Lys Glu Arg Ala Leu Pro Asp Ile Glu Asn 
        755                 760                 765             


Tyr Met Phe Glu Asn His Asp Gln Leu Arg Gln Ala Ala Thr Glu Cys 
    770                 775                 780                 


Met Cys Asn Met Val Leu His Lys Glu Val Gln Glu Arg Phe Leu Ala 
785                 790                 795                 800 


Asp Gly Asn Asp Arg Leu Lys Leu Val Val Leu Leu Cys Gly Glu Asp 
                805                 810                 815     


Asp Asp Lys Val Gln Asn Ala Ala Ala Gly Ala Leu Ala Met Leu Thr 
            820                 825                 830         


Ala Ala His Lys Lys Leu Cys Leu Lys Met Thr Gln Val Thr Thr Gln 
        835                 840                 845             


Trp Leu Glu Ile Leu Gln Arg Leu Cys Leu His Asp Gln Leu Ser Val 
    850                 855                 860                 


Gln His Arg Gly Leu Val Ile Ala Tyr Asn Leu Leu Ala Ala Asp Ala 
865                 870                 875                 880 


Glu Leu Ala Lys Lys Leu Val Glu Ser Glu Leu Leu Glu Ile Leu Thr 
                885                 890                 895     


Val Val Gly Lys Gln Glu Pro Asp Glu Lys Lys Ala Glu Val Val Gln 
            900                 905                 910         


Thr Ala Arg Glu Cys Leu Ile Lys Cys Met Asp Tyr Gly Phe Ile Lys 
        915                 920                 925             


Pro Val Ser 
    930     


<210> 6870
<211> 105
<212> PRT
<213> Homo sapiens

<400> 6870
Met Ala Leu Arg Tyr Pro Met Ala Val Gly Leu Asn Lys Gly His Lys 
1               5                   10                  15      


Val Thr Lys Asn Val Ser Lys Pro Arg His Ser Arg Arg Arg Gly Arg 
            20                  25                  30          


Leu Thr Lys His Thr Lys Phe Val Arg Asp Met Ile Arg Glu Val Cys 
        35                  40                  45              


Gly Phe Ala Pro Tyr Glu Arg Arg Ala Met Glu Leu Leu Lys Val Ser 
    50                  55                  60                  


Lys Asp Lys Arg Ala Leu Lys Phe Ile Lys Lys Arg Val Gly Thr His 
65                  70                  75                  80  


Ile Arg Ala Lys Arg Lys Arg Glu Glu Leu Ser Asn Val Leu Ala Ala 
                85                  90                  95      


Met Arg Lys Ala Ala Ala Lys Lys Asp 
            100                 105 


<210> 6871
<211> 220
<212> PRT
<213> Homo sapiens

<400> 6871
Met Asn Ser Met Asp Arg His Ile Gln Gln Thr Asn Asp Arg Leu Gln 
1               5                   10                  15      


Cys Ile Lys Gln His Leu Gln Asn Pro Ala Asn Phe His Asn Ala Ala 
            20                  25                  30          


Thr Glu Leu Leu Asp Trp Cys Gly Asp Pro Arg Ala Phe Gln Arg Pro 
        35                  40                  45              


Phe Glu Gln Ser Leu Met Gly Cys Leu Thr Val Val Ser Arg Val Ala 
    50                  55                  60                  


Ala Gln Gln Gly Phe Asp Leu Asp Leu Gly Tyr Arg Leu Leu Ala Val 
65                  70                  75                  80  


Cys Ala Ala Asn Arg Asp Lys Phe Thr Pro Lys Ser Ala Ala Leu Leu 
                85                  90                  95      


Ser Ser Trp Cys Glu Glu Leu Gly Arg Leu Leu Leu Leu Arg His Gln 
            100                 105                 110         


Lys Ser Arg Gln Ser Asp Pro Pro Gly Lys Leu Pro Met Gln Pro Pro 
        115                 120                 125             


Leu Ser Ser Met Ser Ser Met Lys Pro Thr Leu Ser His Ser Asp Gly 
    130                 135                 140                 


Ser Phe Pro Tyr Asp Ser Val Pro Trp Leu Pro Ala Tyr Pro Ala Cys 
145                 150                 155                 160 


Thr Pro Pro Pro Ser Gln Ser His Pro Asn Ser Cys Ser Leu Lys Gln 
                165                 170                 175     


Lys Gln Pro Leu Ala Phe Pro Pro Pro Leu Cys Ser Ile Trp Leu Thr 
            180                 185                 190         


Thr Leu Gln Gly Leu Leu Gly Ser Leu Ser Cys Val His Phe Val Ser 
        195                 200                 205             


Gly Trp Ser Val Pro Arg Glu Pro His Gly Leu Gly 
    210                 215                 220 


<210> 6872
<211> 117
<212> PRT
<213> Homo sapiens

<400> 6872
Met Val Gln Arg Leu Thr Tyr Arg Arg Arg Leu Ser Tyr Asn Thr Ala 
1               5                   10                  15      


Ser Asn Lys Thr Arg Leu Ser Arg Thr Pro Gly Asn Arg Ile Val Tyr 
            20                  25                  30          


Leu Tyr Thr Lys Lys Val Gly Lys Ala Pro Lys Ser Ala Cys Gly Val 
        35                  40                  45              


Cys Pro Gly Arg Leu Arg Gly Val Arg Ala Val Arg Pro Lys Val Leu 
    50                  55                  60                  


Met Arg Leu Ser Lys Thr Lys Lys His Val Ser Arg Ala Tyr Gly Gly 
65                  70                  75                  80  


Ser Met Cys Ala Lys Cys Val Arg Asp Arg Ile Lys Arg Ala Phe Leu 
                85                  90                  95      


Ile Glu Glu Gln Lys Ile Val Val Lys Val Leu Lys Ala Gln Ala Gln 
            100                 105                 110         


Ser Gln Lys Ala Lys 
        115         


<210> 6873
<211> 117
<212> PRT
<213> Homo sapiens

<400> 6873
Met Val Gln Arg Leu Thr Tyr Arg Arg Arg Leu Ser Tyr Asn Thr Ala 
1               5                   10                  15      


Ser Asn Lys Thr Arg Leu Ser Arg Thr Pro Gly Asn Arg Ile Val Tyr 
            20                  25                  30          


Leu Tyr Thr Lys Lys Val Gly Lys Ala Pro Lys Ser Ala Cys Gly Val 
        35                  40                  45              


Cys Pro Gly Arg Leu Arg Gly Val Arg Ala Val Arg Pro Lys Val Leu 
    50                  55                  60                  


Met Arg Leu Ser Lys Thr Lys Lys His Val Ser Arg Ala Tyr Gly Gly 
65                  70                  75                  80  


Ser Met Cys Ala Lys Cys Val Arg Asp Arg Ile Lys Arg Ala Phe Leu 
                85                  90                  95      


Ile Glu Glu Gln Lys Ile Val Val Lys Val Leu Lys Ala Gln Ala Gln 
            100                 105                 110         


Ser Gln Lys Ala Lys 
        115         


<210> 6874
<211> 117
<212> PRT
<213> Homo sapiens

<400> 6874
Met Val Gln Arg Leu Thr Tyr Arg Arg Arg Leu Ser Tyr Asn Thr Ala 
1               5                   10                  15      


Ser Asn Lys Thr Arg Leu Ser Arg Thr Pro Gly Asn Arg Ile Val Tyr 
            20                  25                  30          


Leu Tyr Thr Lys Lys Val Gly Lys Ala Pro Lys Ser Ala Cys Gly Val 
        35                  40                  45              


Cys Pro Gly Arg Leu Arg Gly Val Arg Ala Val Arg Pro Lys Val Leu 
    50                  55                  60                  


Met Arg Leu Ser Lys Thr Lys Lys His Val Ser Arg Ala Tyr Gly Gly 
65                  70                  75                  80  


Ser Met Cys Ala Lys Cys Val Arg Asp Arg Ile Lys Arg Ala Phe Leu 
                85                  90                  95      


Ile Glu Glu Gln Lys Ile Val Val Lys Val Leu Lys Ala Gln Ala Gln 
            100                 105                 110         


Ser Gln Lys Ala Lys 
        115         


<210> 6875
<211> 633
<212> PRT
<213> Homo sapiens

<400> 6875
Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr Cys Asp Cys Lys Ile Phe Lys Ile 
        35                  40                  45              


Cys Leu Val Val Thr Lys Glu Val Ser Arg Asp Ser Ser Leu Leu Arg 
    50                  55                  60                  


Asp Asp Leu Ile Gln Asp Val Glu Ile Gln Ile Ile Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Pro Pro Ile Val Gln Asn Cys Cys Leu Pro Ala Val Val Glu Arg 
                85                  90                  95      


Ser Asp Asn Phe Cys Arg Ala Gly Leu Ala Val Val Leu Arg His Ile 
            100                 105                 110         


Ile Gln Lys Ser Tyr Glu Ala Asp Pro Leu Lys Lys Glu Leu Leu Glu 
        115                 120                 125             


Leu Leu Gly Phe Lys Lys Thr Cys Leu Lys Ala Cys Ala Glu Val Ser 
    130                 135                 140                 


Gln Trp Thr Arg Leu Cys Glu Leu Thr Ile Pro Leu Ala Ile Glu Asn 
145                 150                 155                 160 


Phe Leu Arg Glu Ser Ser Asp Gln Pro Pro Thr Ile Pro Val Glu Ile 
                165                 170                 175     


Leu Gln Leu Glu Lys Lys Leu Ser Glu Pro Val Arg Val His Asn Asp 
            180                 185                 190         


Asp Lys Leu Arg Arg Gln Lys Leu Lys Gln Gln Lys Ala Asp Gly Val 
        195                 200                 205             


Gly Pro Pro Leu Thr Lys Gly Lys Ala Lys Ser Lys Val His Thr Gln 
    210                 215                 220                 


Glu Thr Ser Glu Gly Leu Asp Ser Ser Ser Lys Ser Leu Glu Leu Lys 
225                 230                 235                 240 


Val Ala Phe Ser Lys Leu Thr Val Gln Glu Glu Pro Ala Thr Thr Asn 
                245                 250                 255     


Arg Glu Pro Ser His Ile Arg Lys Ala Lys Ala Ser Asp Leu Pro Pro 
            260                 265                 270         


Leu Glu His Val Phe Ala Glu Gly Leu Tyr Phe Thr Leu Ala Asp Ile 
        275                 280                 285             


Val Leu Leu Pro Cys Ile His His Phe Leu Val Ile Ile Ser Arg Lys 
    290                 295                 300                 


Phe Ser Glu Lys Leu Val Glu Phe Pro Leu Leu Ala Ser Trp Tyr Gln 
305                 310                 315                 320 


Arg Ile Gln Glu Val Pro Gly Val Lys Thr Ala Ala Ser Lys Cys Gly 
                325                 330                 335     


Ile Gln Phe Leu His Leu Pro Lys Leu Leu Thr Thr Ser Thr Glu Gln 
            340                 345                 350         


His Pro Asn Leu Cys Glu Val Pro Gly Val Glu Glu Gln Ser Asp Pro 
        355                 360                 365             


Leu Phe Ile Gly Gly Pro Arg Pro Thr Met Ala Lys Leu Met Glu Lys 
    370                 375                 380                 


Gly Ile Glu Val Met Phe Ser Pro His Pro Cys Pro Thr Trp Thr Leu 
385                 390                 395                 400 


Asp Trp Asn Val Leu Pro Ala Ala Val Ser Pro Lys Glu Gly Lys Met 
                405                 410                 415     


Ser Ser Asp Arg Ala Leu Arg Lys Gln Gln Gln Leu Asn Asn Leu Val 
            420                 425                 430         


Tyr Val Val Thr Asn Gln Ala Lys Pro Gly Asp Arg Ile Val Asp Phe 
        435                 440                 445             


Cys Ser Gly Gly Gly His Val Gly Ile Val Leu Ala His Met Leu Pro 
    450                 455                 460                 


Ser Cys Gln Val Thr Leu Ile Glu Asn Lys Glu Leu Ser Leu Ile Arg 
465                 470                 475                 480 


Ala Lys Lys Arg Ser Asp Glu Leu Gly Leu Ser Asn Ile Trp Phe Ile 
                485                 490                 495     


Gln Ala Asn Met Glu Tyr Phe Thr Gly Met Phe Asn Ile Gly Val Ala 
            500                 505                 510         


Leu His Ala Cys Gly Val Ala Thr Asp Met Val Ile Glu His Cys Ile 
        515                 520                 525             


Lys Thr Arg Ala Ser Phe Val Thr Cys Pro Cys Cys Tyr Gly Phe Ile 
    530                 535                 540                 


Gln Asn Thr Ser Lys Phe Asn Phe Pro Lys Ser Glu Gln Phe Lys Lys 
545                 550                 555                 560 


Thr Leu Ser Tyr Lys Glu His Met Ile Leu Cys Arg Phe Ala Asp Gln 
                565                 570                 575     


Thr Ala Val Gln Leu Pro Pro Gln Arg Arg Leu Ile Gly Lys Gln Cys 
            580                 585                 590         


Met Cys Leu Val Asp Leu Asp Arg Ala Arg Ala Ala Glu Glu Cys Gly 
        595                 600                 605             


Tyr Ser Val Gln Val Ile Ser Met Glu Pro Glu Ser Cys Ser Pro Lys 
    610                 615                 620                 


Asn Asn Met Ile Val Gly Val Pro Ile 
625                 630             


<210> 6876
<211> 546
<212> PRT
<213> Homo sapiens

<400> 6876
Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr Cys Asp Cys Lys Ile Phe Lys Ile 
        35                  40                  45              


Cys Leu Val Val Thr Lys Glu Val Ser Gln Trp Thr Arg Leu Cys Glu 
    50                  55                  60                  


Leu Thr Ile Pro Leu Ala Ile Glu Asn Phe Leu Arg Glu Ser Ser Asp 
65                  70                  75                  80  


Gln Pro Pro Thr Ile Pro Val Glu Ile Leu Gln Leu Glu Lys Lys Leu 
                85                  90                  95      


Ser Glu Pro Val Arg Val His Asn Asp Asp Lys Leu Arg Arg Gln Lys 
            100                 105                 110         


Leu Lys Gln Gln Lys Ala Asp Gly Val Gly Pro Pro Leu Thr Lys Gly 
        115                 120                 125             


Lys Ala Lys Ser Lys Val His Thr Gln Glu Thr Ser Glu Gly Leu Asp 
    130                 135                 140                 


Ser Ser Ser Lys Ser Leu Glu Leu Lys Val Ala Phe Ser Lys Leu Thr 
145                 150                 155                 160 


Val Gln Glu Glu Pro Ala Thr Thr Asn Arg Glu Pro Ser His Ile Arg 
                165                 170                 175     


Lys Ala Lys Ala Ser Asp Leu Pro Pro Leu Glu His Val Phe Ala Glu 
            180                 185                 190         


Gly Leu Tyr Phe Thr Leu Ala Asp Ile Val Leu Leu Pro Cys Ile His 
        195                 200                 205             


His Phe Leu Val Ile Ile Ser Arg Lys Phe Ser Glu Lys Leu Val Glu 
    210                 215                 220                 


Phe Pro Leu Leu Ala Ser Trp Tyr Gln Arg Ile Gln Glu Val Pro Gly 
225                 230                 235                 240 


Val Lys Thr Ala Ala Ser Lys Cys Gly Ile Gln Phe Leu His Leu Pro 
                245                 250                 255     


Lys Leu Leu Thr Thr Ser Thr Glu Gln His Pro Asn Leu Cys Glu Val 
            260                 265                 270         


Pro Gly Val Glu Glu Gln Ser Asp Pro Leu Phe Ile Gly Gly Pro Arg 
        275                 280                 285             


Pro Thr Met Ala Lys Leu Met Glu Lys Gly Ile Glu Val Met Phe Ser 
    290                 295                 300                 


Pro His Pro Cys Pro Thr Trp Thr Leu Asp Trp Asn Val Leu Pro Ala 
305                 310                 315                 320 


Ala Val Ser Pro Lys Glu Gly Lys Met Ser Ser Asp Arg Ala Leu Arg 
                325                 330                 335     


Lys Gln Gln Gln Leu Asn Asn Leu Val Tyr Val Val Thr Asn Gln Ala 
            340                 345                 350         


Lys Pro Gly Asp Arg Ile Val Asp Phe Cys Ser Gly Gly Gly His Val 
        355                 360                 365             


Gly Ile Val Leu Ala His Met Leu Pro Ser Cys Gln Val Thr Leu Ile 
    370                 375                 380                 


Glu Asn Lys Glu Leu Ser Leu Ile Arg Ala Lys Lys Arg Ser Asp Glu 
385                 390                 395                 400 


Leu Gly Leu Ser Asn Ile Trp Phe Ile Gln Ala Asn Met Glu Tyr Phe 
                405                 410                 415     


Thr Gly Met Phe Asn Ile Gly Val Ala Leu His Ala Cys Gly Val Ala 
            420                 425                 430         


Thr Asp Met Val Ile Glu His Cys Ile Lys Thr Arg Ala Ser Phe Val 
        435                 440                 445             


Thr Cys Pro Cys Cys Tyr Gly Phe Ile Gln Asn Thr Ser Lys Phe Asn 
    450                 455                 460                 


Phe Pro Lys Ser Glu Gln Phe Lys Lys Thr Leu Ser Tyr Lys Glu His 
465                 470                 475                 480 


Met Ile Leu Cys Arg Phe Ala Asp Gln Thr Ala Val Gln Leu Pro Pro 
                485                 490                 495     


Gln Arg Arg Leu Ile Gly Lys Gln Cys Met Cys Leu Val Asp Leu Asp 
            500                 505                 510         


Arg Ala Arg Ala Ala Glu Glu Cys Gly Tyr Ser Val Gln Val Ile Ser 
        515                 520                 525             


Met Glu Pro Glu Ser Cys Ser Pro Lys Asn Asn Met Ile Val Gly Val 
    530                 535                 540                 


Pro Ile 
545     


<210> 6877
<211> 513
<212> PRT
<213> Homo sapiens

<400> 6877
Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn Thr Asn Leu 
1               5                   10                  15      


Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu Leu Ser Cys 
            20                  25                  30          


Leu Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn Arg Phe Ser 
        35                  40                  45              


Gln Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln Ile His Lys 
    50                  55                  60                  


Arg Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys Ser Leu Glu 
65                  70                  75                  80  


Thr Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn Lys Asn Glu 
                85                  90                  95      


Ala Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val Ala Leu Lys 
            100                 105                 110         


Lys Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe Thr Gly Ala 
        115                 120                 125             


Ile Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala Lys Leu Ser 
    130                 135                 140                 


Glu Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr Met Lys Lys 
                165                 170                 175     


Gln Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu Asp His Gly 
            180                 185                 190         


Lys Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser Ile Glu Tyr 
        195                 200                 205             


Glu Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys Thr Thr Leu 
    210                 215                 220                 


Ala Ala Leu Lys Asp Glu Val Val Ser Val Glu Asn Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Gln Glu Val Glu Lys Lys Gln Lys Thr Leu Ile Glu Met Tyr Lys 
                245                 250                 255     


Thr Gln Val Gln Lys Leu Gln Glu Ala Ala Glu Ile Val Lys Ser Arg 
            260                 265                 270         


Cys Glu Asn Leu Leu His Lys Asn Asn Gln Ile Thr Lys Thr Lys Asn 
        275                 280                 285             


Lys Asn Val Glu Lys Met Arg Gly Gln Met Glu Ser His Leu Lys Glu 
    290                 295                 300                 


Leu Glu Arg Val Cys Asp Ser Leu Thr Ala Ala Glu Arg Arg Leu His 
305                 310                 315                 320 


Glu Cys Gln Glu Ser Leu Gln Cys Cys Lys Gly Lys Cys Ala Asp Gln 
                325                 330                 335     


Glu His Thr Ile Arg Glu Leu Gln Gly Gln Val Asp Gly Asn His Asn 
            340                 345                 350         


Leu Leu Thr Lys Leu Ser Leu Glu Glu Glu Asn Cys Leu Ile Gln Leu 
        355                 360                 365             


Lys Cys Glu Asn Leu Gln Gln Lys Leu Glu Gln Met Asp Ala Glu Asn 
    370                 375                 380                 


Lys Glu Leu Glu Lys Lys Leu Ala Asn Gln Glu Glu Cys Leu Lys His 
385                 390                 395                 400 


Ser Asn Leu Lys Phe Lys Glu Lys Ser Ala Glu Tyr Thr Ala Leu Ala 
                405                 410                 415     


Arg Gln Leu Glu Ala Ala Leu Glu Glu Gly Arg Gln Lys Val Ala Glu 
            420                 425                 430         


Glu Ile Glu Lys Met Ser Ser Arg Glu Ser Ala Leu Gln Ile Lys Ile 
        435                 440                 445             


Leu Asp Leu Glu Thr Glu Leu Arg Lys Lys Asn Glu Glu Gln Asn Gln 
    450                 455                 460                 


Leu Val Cys Lys Met Asn Ser Lys Ala Gln His Gln Glu Val Cys Leu 
465                 470                 475                 480 


Lys Glu Val Gln Asn Ser Leu Glu Lys Ser Glu Asn Gln Asn Glu Ser 
                485                 490                 495     


Ile Lys Asn Tyr Leu Gln Phe Leu Lys Thr Ser Tyr Val Thr Met Phe 
            500                 505                 510         


Glu 
    


<210> 6878
<211> 388
<212> PRT
<213> Homo sapiens

<400> 6878
Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu Gln Lys Gln Ser Arg 
1               5                   10                  15      


Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg Asn Gln Val Arg Lys 
            20                  25                  30          


Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser Pro Glu Ala Pro Gly 
        35                  40                  45              


Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly Ser Ala His Leu Ala 
    50                  55                  60                  


Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr Gly Ala Thr Leu Arg 
65                  70                  75                  80  


Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala Ile Leu Leu His Phe 
                85                  90                  95      


Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys Ile Tyr Thr Phe Asn 
            100                 105                 110         


Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp Thr Ile Ala Lys Tyr 
        115                 120                 125             


Leu Asp Asn Ile His Leu His Pro Glu Glu Glu Lys Tyr Arg Lys Ile 
    130                 135                 140                 


Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile Asn Cys Leu Glu Gly 
145                 150                 155                 160 


Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln Lys Val Leu Leu Pro 
                165                 170                 175     


Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr Val Leu Ser Glu Thr 
            180                 185                 190         


Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His Lys Glu Gln Leu Leu 
        195                 200                 205             


Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg Gln Arg Arg Val Phe 
    210                 215                 220                 


Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu Pro Gly Asp Phe Phe 
225                 230                 235                 240 


Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln Arg Leu Arg Ser Glu 
                245                 250                 255     


Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys Ala Met Arg Glu Lys 
            260                 265                 270         


Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr Thr Leu Leu Arg Val 
        275                 280                 285             


Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr Phe Tyr Ala Arg Glu 
    290                 295                 300                 


Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu Ala Leu Gln Ser Asp 
305                 310                 315                 320 


Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly Gln Lys Leu Ser Glu 
                325                 330                 335     


Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu Val Pro Ser Ala Leu 
            340                 345                 350         


Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu Asp Ile Lys Ala Ala 
        355                 360                 365             


Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu Leu Leu Ser Ala Ile 
    370                 375                 380                 


Glu Lys Leu Leu 
385             


<210> 6879
<211> 896
<212> PRT
<213> Homo sapiens

<400> 6879
Met Asp Gly Ala Ala Gly Pro Gly Asp Gly Pro Ala Arg Glu Ala Leu 
1               5                   10                  15      


Gln Ser Leu Ser Gln Arg Leu Arg Val Gln Glu Gln Glu Met Glu Leu 
            20                  25                  30          


Val Lys Ala Ala Leu Ala Glu Ala Leu Arg Leu Leu Arg Leu Gln Val 
        35                  40                  45              


Pro Pro Ser Ser Leu Gln Gly Ser Gly Thr Pro Ala Pro Pro Gly Asp 
    50                  55                  60                  


Ser Leu Ala Ala Pro Pro Gly Leu Pro Pro Thr Cys Thr Pro Ser Leu 
65                  70                  75                  80  


Val Ser Arg Gly Thr Gln Thr Glu Thr Glu Val Glu Leu Lys Ser Ser 
                85                  90                  95      


Pro Gly Pro Pro Gly Leu Ser Asn Gly Pro Pro Ala Pro Gln Gly Ala 
            100                 105                 110         


Ser Glu Glu Pro Ser Gly Thr Gln Ser Glu Gly Gly Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ala Gly Ser Pro Gly Pro Pro Gly Ile Leu Arg Pro Leu Gln 
    130                 135                 140                 


Pro Pro Gln Arg Ala Asp Thr Pro Arg Arg Asn Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ser Pro Ser Glu Arg Pro Arg Gln Lys Leu Ser Arg Lys Ala Ile Ser 
                165                 170                 175     


Ser Ala Asn Leu Leu Val Arg Ser Gly Ser Thr Glu Ser Arg Gly Gly 
            180                 185                 190         


Lys Asp Pro Leu Ser Ser Pro Gly Gly Pro Gly Ser Arg Arg Ser Asn 
        195                 200                 205             


Tyr Asn Leu Glu Gly Ile Ser Val Lys Met Phe Leu Arg Gly Arg Pro 
    210                 215                 220                 


Ile Thr Met Tyr Ile Pro Ser Gly Ile Arg Ser Leu Glu Glu Leu Pro 
225                 230                 235                 240 


Ser Gly Pro Pro Pro Glu Thr Leu Ser Leu Asp Trp Val Tyr Gly Tyr 
                245                 250                 255     


Arg Gly Arg Asp Ser Arg Ser Asn Leu Phe Val Leu Arg Ser Gly Glu 
            260                 265                 270         


Val Val Tyr Phe Ile Ala Cys Val Val Val Leu Tyr Arg Pro Gly Gly 
        275                 280                 285             


Gly Pro Gly Gly Pro Gly Gly Gly Gly Gln Arg His Tyr Arg Gly His 
    290                 295                 300                 


Thr Asp Cys Val Arg Cys Leu Ala Val His Pro Asp Gly Val Arg Val 
305                 310                 315                 320 


Ala Ser Gly Gln Thr Ala Gly Val Asp Lys Asp Gly Lys Pro Leu Gln 
                325                 330                 335     


Pro Val Val His Ile Trp Asp Ser Glu Thr Leu Leu Lys Leu Gln Glu 
            340                 345                 350         


Ile Gly Leu Gly Ala Phe Glu Arg Gly Val Gly Ala Leu Ala Phe Ser 
        355                 360                 365             


Ala Ala Asp Gln Gly Ala Phe Leu Cys Val Val Asp Asp Ser Asn Glu 
    370                 375                 380                 


His Met Leu Ser Val Trp Asp Cys Ser Arg Gly Met Lys Leu Ala Glu 
385                 390                 395                 400 


Ile Lys Ser Thr Asn Asp Ser Val Leu Ala Val Gly Phe Asn Pro Arg 
                405                 410                 415     


Asp Ser Ser Cys Ile Val Thr Ser Gly Lys Ser His Val His Phe Trp 
            420                 425                 430         


Asn Trp Ser Gly Gly Val Gly Val Pro Gly Asn Gly Thr Leu Thr Arg 
        435                 440                 445             


Lys Gln Gly Val Phe Gly Lys Tyr Lys Lys Pro Lys Phe Ile Pro Cys 
    450                 455                 460                 


Phe Val Phe Leu Pro Asp Gly Asp Ile Leu Thr Gly Asp Ser Glu Gly 
465                 470                 475                 480 


Asn Ile Leu Thr Trp Gly Arg Ser Pro Ser Asp Ser Lys Thr Pro Gly 
                485                 490                 495     


Arg Gly Gly Ala Lys Glu Thr Tyr Gly Ile Val Ala Gln Ala His Ala 
            500                 505                 510         


His Glu Gly Ser Ile Phe Ala Leu Cys Leu Arg Arg Asp Gly Thr Val 
        515                 520                 525             


Leu Ser Gly Gly Gly Arg Asp Arg Arg Leu Val Gln Trp Gly Pro Gly 
    530                 535                 540                 


Leu Val Ala Leu Gln Glu Ala Glu Ile Pro Glu His Phe Gly Ala Val 
545                 550                 555                 560 


Arg Ala Ile Ala Glu Gly Leu Gly Ser Glu Leu Leu Val Gly Thr Thr 
                565                 570                 575     


Lys Asn Ala Leu Leu Arg Gly Asp Leu Ala Gln Gly Phe Ser Pro Val 
            580                 585                 590         


Ile Gln Gly His Thr Asp Glu Leu Trp Gly Leu Cys Thr His Pro Ser 
        595                 600                 605             


Gln Asn Arg Phe Leu Thr Cys Gly His Asp Arg Gln Leu Cys Leu Trp 
    610                 615                 620                 


Asp Gly Glu Ser His Ala Leu Ala Trp Ser Ile Asp Leu Lys Glu Thr 
625                 630                 635                 640 


Gly Leu Cys Ala Asp Phe His Pro Ser Gly Ala Val Val Ala Val Gly 
                645                 650                 655     


Leu Asn Thr Gly Arg Trp Leu Val Leu Asp Thr Glu Thr Arg Glu Ile 
            660                 665                 670         


Val Ser Asp Val Ile Asp Gly Asn Glu Gln Leu Ser Val Val Arg Tyr 
        675                 680                 685             


Ser Pro Asp Gly Leu Tyr Leu Ala Ile Gly Ser His Asp Asn Val Ile 
    690                 695                 700                 


Tyr Ile Tyr Ser Val Ser Ser Asp Gly Ala Lys Ser Ser Arg Phe Gly 
705                 710                 715                 720 


Arg Cys Met Gly His Ser Ser Phe Ile Thr His Leu Asp Trp Ser Lys 
                725                 730                 735     


Asp Gly Asn Phe Ile Met Ser Asn Ser Gly Asp Tyr Glu Ile Leu Tyr 
            740                 745                 750         


Trp Asp Val Ala Gly Gly Cys Lys Gln Leu Lys Asn Arg Tyr Glu Ser 
        755                 760                 765             


Arg Asp Arg Glu Trp Ala Thr Tyr Thr Cys Val Leu Gly Phe His Val 
    770                 775                 780                 


Tyr Gly Val Trp Pro Asp Gly Ser Asp Gly Thr Asp Ile Asn Ser Leu 
785                 790                 795                 800 


Cys Arg Ser His Asn Glu Arg Val Val Ala Val Ala Asp Asp Phe Cys 
                805                 810                 815     


Lys Val His Leu Phe Gln Tyr Pro Cys Ala Arg Ala Lys Ala Pro Ser 
            820                 825                 830         


Arg Met Tyr Gly Gly His Gly Ser His Val Thr Ser Val Arg Phe Thr 
        835                 840                 845             


His Asp Asp Ser His Leu Val Ser Leu Gly Gly Lys Asp Ala Ser Ile 
    850                 855                 860                 


Phe Gln Trp Arg Val Leu Gly Ala Gly Gly Ala Gly Pro Ala Pro Ala 
865                 870                 875                 880 


Thr Pro Ser Arg Thr Pro Ser Leu Ser Pro Ala Ser Ser Leu Asp Val 
                885                 890                 895     


<210> 6880
<211> 977
<212> PRT
<213> Homo sapiens

<400> 6880
Met Gly Ala Glu Glu Glu Val Leu Val Thr Leu Ser Gly Gly Ala Pro 
1               5                   10                  15      


Trp Gly Phe Arg Leu His Gly Gly Ala Glu Gln Arg Lys Pro Leu Gln 
            20                  25                  30          


Val Ser Lys Ile Arg Arg Arg Ser Gln Ala Gly Arg Ala Gly Leu Arg 
        35                  40                  45              


Glu Arg Asp Gln Leu Leu Ala Ile Asn Gly Val Ser Cys Thr Asn Leu 
    50                  55                  60                  


Ser His Ala Ser Ala Met Ser Leu Ile Asp Ala Ser Gly Asn Gln Leu 
65                  70                  75                  80  


Val Leu Thr Val Gln Arg Leu Ala Asp Glu Gly Pro Val Gln Ser Pro 
                85                  90                  95      


Ser Pro His Glu Leu Gln Val Leu Ser Pro Leu Ser Pro Leu Ser Pro 
            100                 105                 110         


Glu Pro Pro Gly Ala Pro Val Pro Gln Pro Leu Gln Pro Gly Ser Leu 
        115                 120                 125             


Arg Ser Pro Pro Asp Ser Glu Ala Tyr Tyr Gly Glu Thr Asp Ser Asp 
    130                 135                 140                 


Ala Asp Gly Pro Ala Thr Gln Glu Lys Pro Arg Arg Pro Arg Arg Arg 
145                 150                 155                 160 


Gly Pro Thr Arg Pro Thr Pro Pro Gly Ala Pro Pro Asp Glu Val Tyr 
                165                 170                 175     


Leu Ser Asp Ser Pro Ala Glu Pro Ala Pro Thr Ile Pro Gly Pro Pro 
            180                 185                 190         


Ser Gln Gly Asp Ser Arg Val Ser Ser Pro Ser Trp Glu Asp Gly Ala 
        195                 200                 205             


Ala Leu Gln Pro Pro Pro Ala Glu Ala Leu Leu Leu Pro His Gly Pro 
    210                 215                 220                 


Leu Arg Pro Gly Pro His Leu Ile Pro Met Val Gly Pro Val Pro His 
225                 230                 235                 240 


Pro Val Ala Glu Asp Leu Thr Thr Thr Tyr Thr Gln Lys Ala Lys Gln 
                245                 250                 255     


Ala Lys Leu Gln Arg Ala Glu Ser Leu Gln Glu Lys Ser Ile Lys Glu 
            260                 265                 270         


Ala Lys Thr Lys Cys Arg Thr Ile Ala Ser Leu Leu Thr Ala Ala Pro 
        275                 280                 285             


Asn Pro His Ser Lys Gly Val Leu Met Phe Lys Lys Arg Arg Gln Arg 
    290                 295                 300                 


Ala Lys Lys Tyr Thr Leu Val Ser Phe Gly Ala Ala Ala Gly Thr Gly 
305                 310                 315                 320 


Ala Glu Glu Glu Asp Gly Val Pro Pro Thr Ser Glu Ser Glu Leu Asp 
                325                 330                 335     


Glu Glu Ala Phe Ser Asp Ala Arg Ser Leu Thr Asn Gln Ser Asp Trp 
            340                 345                 350         


Asp Ser Pro Tyr Leu Asp Met Glu Leu Ala Arg Ala Gly Ser Arg Ala 
        355                 360                 365             


Ser Glu Gly Gln Gly Ser Gly Leu Gly Gly Gln Leu Ser Glu Val Ser 
    370                 375                 380                 


Gly Arg Gly Val Gln Leu Phe Glu Gln Gln Arg Gln Arg Ala Asp Ser 
385                 390                 395                 400 


Ser Thr Gln Glu Leu Ala Arg Val Glu Pro Ala Ala Met Leu Asn Gly 
                405                 410                 415     


Glu Gly Leu Gln Ser Pro Pro Arg Ala Gln Ser Ala Pro Pro Glu Ala 
            420                 425                 430         


Ala Val Leu Pro Pro Ser Pro Leu Pro Ala Pro Val Ala Ser Pro Arg 
        435                 440                 445             


Pro Phe Gln Pro Gly Gly Gly Ala Pro Thr Pro Ala Pro Ser Ile Phe 
    450                 455                 460                 


Asn Arg Ser Ala Arg Pro Phe Thr Pro Gly Leu Gln Gly Gln Arg Pro 
465                 470                 475                 480 


Thr Thr Thr Ser Val Ile Phe Arg Pro Leu Ala Pro Lys Arg Ala Asn 
                485                 490                 495     


Asp Ser Leu Gly Gly Leu Ser Pro Ala Pro Pro Pro Phe Leu Ser Ser 
            500                 505                 510         


Gln Gly Pro Thr Pro Leu Pro Ser Phe Thr Ser Gly Val Pro Ser His 
        515                 520                 525             


Ala Pro Val Ser Gly Ser Pro Ser Thr Pro Arg Ser Ser Gly Pro Val 
    530                 535                 540                 


Thr Ala Thr Ser Ser Leu Tyr Ile Pro Ala Pro Ser Arg Pro Val Thr 
545                 550                 555                 560 


Pro Gly Gly Ala Pro Glu Pro Pro Ala Pro Pro Ser Ala Ala Ala Met 
                565                 570                 575     


Thr Ser Thr Ala Ser Ile Phe Leu Ser Ala Pro Leu Arg Pro Ser Ala 
            580                 585                 590         


Arg Pro Glu Ala Pro Ala Pro Gly Pro Gly Ala Pro Glu Pro Pro Ser 
        595                 600                 605             


Ala Arg Glu Gln Arg Ile Ser Val Pro Ala Ala Arg Thr Gly Ile Leu 
    610                 615                 620                 


Gln Glu Ala Arg Arg Arg Gly Thr Arg Lys Gln Met Phe Arg Pro Gly 
625                 630                 635                 640 


Lys Glu Glu Thr Lys Asn Ser Pro Asn Pro Glu Leu Leu Ser Leu Val 
                645                 650                 655     


Gln Asn Leu Asp Glu Lys Pro Arg Ala Gly Gly Ala Glu Ser Gly Pro 
            660                 665                 670         


Glu Glu Asp Ala Leu Ser Leu Gly Ala Glu Ala Cys Asn Phe Met Gln 
        675                 680                 685             


Pro Val Gly Ala Arg Ser Tyr Lys Thr Leu Pro His Val Thr Pro Lys 
    690                 695                 700                 


Thr Pro Pro Pro Met Ala Pro Lys Thr Pro Pro Pro Met Thr Pro Lys 
705                 710                 715                 720 


Thr Pro Pro Pro Val Ala Pro Lys Pro Pro Ser Arg Gly Leu Leu Asp 
                725                 730                 735     


Gly Leu Val Asn Gly Ala Ala Ser Ser Ala Gly Ile Pro Glu Pro Pro 
            740                 745                 750         


Arg Leu Gln Gly Arg Gly Gly Glu Leu Phe Ala Lys Arg Gln Ser Arg 
        755                 760                 765             


Ala Asp Arg Tyr Val Val Glu Gly Thr Pro Gly Pro Gly Leu Gly Pro 
    770                 775                 780                 


Arg Pro Arg Ser Pro Ser Pro Thr Pro Ser Leu Pro Pro Ser Trp Lys 
785                 790                 795                 800 


Tyr Ser Pro Asn Ile Arg Ala Pro Pro Pro Ile Ala Tyr Asn Pro Leu 
                805                 810                 815     


Leu Ser Pro Phe Phe Pro Gln Ala Ala Arg Thr Leu Pro Lys Ala Gln 
            820                 825                 830         


Ser Gln Gly Pro Arg Ala Thr Pro Lys Gln Gly Ile Lys Ala Leu Asp 
        835                 840                 845             


Phe Met Arg His Gln Pro Tyr Gln Leu Lys Thr Ala Met Phe Cys Phe 
    850                 855                 860                 


Asp Glu Val Pro Pro Thr Pro Gly Pro Ile Ala Ser Gly Ser Pro Lys 
865                 870                 875                 880 


Thr Ala Arg Val Gln Glu Ile Arg Arg Phe Ser Thr Pro Ala Pro Gln 
                885                 890                 895     


Pro Thr Ala Glu Pro Leu Ala Pro Thr Val Leu Ala Pro Arg Ala Ala 
            900                 905                 910         


Thr Thr Leu Asp Glu Pro Ile Trp Arg Thr Glu Leu Ala Ser Ala Pro 
        915                 920                 925             


Val Pro Ser Pro Ala Pro Pro Pro Glu Ala Pro Arg Gly Leu Gly Ala 
    930                 935                 940                 


Ser Pro Ser Ser Cys Gly Phe Gln Val Ala Arg Pro Arg Phe Ser Ala 
945                 950                 955                 960 


Thr Arg Thr Gly Leu Gln Ala His Val Trp Arg Pro Gly Ala Gly His 
                965                 970                 975     


Gln 
    


<210> 6881
<211> 918
<212> PRT
<213> Homo sapiens

<400> 6881
Met Gly Thr Thr Ala Pro Gly Pro Ile His Leu Leu Glu Leu Cys Asp 
1               5                   10                  15      


Gln Lys Leu Met Glu Phe Leu Cys Asn Met Asp Asn Lys Asp Leu Val 
            20                  25                  30          


Trp Leu Glu Glu Ile Gln Glu Glu Ala Glu Arg Met Phe Thr Arg Glu 
        35                  40                  45              


Phe Ser Lys Glu Pro Glu Leu Met Pro Lys Thr Pro Ser Gln Lys Asn 
    50                  55                  60                  


Arg Arg Lys Lys Arg Arg Ile Ser Tyr Val Gln Asp Glu Asn Arg Asp 
65                  70                  75                  80  


Pro Ile Arg Arg Arg Leu Ser Arg Arg Lys Ser Arg Ser Ser Gln Leu 
                85                  90                  95      


Ser Ser Arg Arg Leu Arg Ser Lys Asp Ser Val Glu Lys Leu Ala Thr 
            100                 105                 110         


Val Val Gly Glu Asn Gly Ser Val Leu Arg Arg Val Thr Arg Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Thr Met Ala Leu Ala Ala Pro Ser Ser Pro 
    130                 135                 140                 


Thr Pro Glu Ser Pro Thr Met Leu Thr Lys Lys Pro Glu Asp Asn His 
145                 150                 155                 160 


Thr Gln Cys Gln Leu Val Pro Val Val Glu Ile Gly Ile Ser Glu Arg 
                165                 170                 175     


Gln Asn Ala Glu Gln His Val Thr Gln Leu Met Ser Thr Glu Pro Leu 
            180                 185                 190         


Pro Arg Thr Leu Ser Pro Thr Pro Ala Ser Ala Thr Ala Pro Thr Ser 
        195                 200                 205             


Gln Gly Ile Pro Thr Ser Asp Glu Glu Ser Thr Pro Lys Lys Ser Lys 
    210                 215                 220                 


Ala Arg Ile Leu Glu Ser Ile Thr Val Ser Ser Leu Met Ala Thr Pro 
225                 230                 235                 240 


Gln Asp Pro Lys Gly Gln Gly Val Gly Thr Gly Arg Ser Ala Ser Lys 
                245                 250                 255     


Leu Arg Ile Ala Gln Val Ser Pro Gly Pro Arg Asp Ser Pro Ala Phe 
            260                 265                 270         


Pro Asp Ser Pro Trp Arg Glu Arg Val Leu Ala Pro Ile Leu Pro Asp 
        275                 280                 285             


Asn Phe Ser Thr Pro Thr Gly Ser Arg Thr Asp Ser Gln Ser Val Arg 
    290                 295                 300                 


His Ser Pro Ile Ala Pro Ser Ser Pro Ser Pro Gln Val Leu Ala Gln 
305                 310                 315                 320 


Lys Tyr Ser Leu Val Ala Lys Gln Glu Ser Val Val Arg Arg Ala Ser 
                325                 330                 335     


Arg Arg Leu Ala Lys Lys Thr Ala Glu Glu Pro Ala Ala Ser Gly Arg 
            340                 345                 350         


Ile Ile Cys His Ser Tyr Leu Glu Arg Leu Leu Asn Val Glu Val Pro 
        355                 360                 365             


Gln Lys Val Gly Ser Glu Gln Lys Glu Pro Pro Glu Glu Ala Glu Pro 
    370                 375                 380                 


Val Ala Ala Ala Glu Pro Glu Val Pro Glu Asn Asn Gly Asn Asn Ser 
385                 390                 395                 400 


Trp Pro His Asn Asp Thr Glu Ile Ala Asn Ser Thr Pro Asn Pro Lys 
                405                 410                 415     


Pro Ala Ala Ser Ser Pro Glu Thr Pro Ser Ala Gly Gln Gln Glu Ala 
            420                 425                 430         


Lys Thr Asp Gln Ala Asp Gly Pro Arg Glu Pro Pro Gln Ser Ala Arg 
        435                 440                 445             


Arg Lys Arg Ser Tyr Lys Gln Ala Val Ser Glu Leu Asp Glu Glu Gln 
    450                 455                 460                 


His Leu Glu Asp Glu Glu Leu Gln Pro Pro Arg Ser Lys Thr Pro Ser 
465                 470                 475                 480 


Ser Pro Cys Pro Ala Ser Lys Val Val Arg Pro Leu Arg Thr Phe Leu 
                485                 490                 495     


His Thr Val Gln Arg Asn Gln Met Leu Met Thr Pro Thr Ser Ala Pro 
            500                 505                 510         


Arg Ser Val Met Lys Ser Phe Ile Lys Arg Asn Thr Pro Leu Arg Met 
        515                 520                 525             


Asp Pro Lys Cys Ser Phe Val Glu Lys Glu Arg Gln Arg Leu Glu Asn 
    530                 535                 540                 


Leu Arg Arg Lys Glu Glu Ala Glu Gln Leu Arg Arg Gln Lys Val Glu 
545                 550                 555                 560 


Glu Asp Lys Arg Arg Arg Leu Glu Glu Val Lys Leu Lys Arg Glu Glu 
                565                 570                 575     


Arg Leu Arg Lys Val Leu Gln Ala Arg Glu Arg Val Glu Gln Met Lys 
            580                 585                 590         


Glu Glu Lys Lys Lys Gln Ile Glu Gln Lys Phe Ala Gln Ile Asp Glu 
        595                 600                 605             


Lys Thr Glu Lys Ala Lys Glu Glu Arg Leu Ala Glu Glu Lys Ala Lys 
    610                 615                 620                 


Lys Lys Ala Ala Ala Lys Lys Met Glu Glu Val Glu Ala Arg Arg Lys 
625                 630                 635                 640 


Gln Glu Glu Glu Ala Arg Arg Leu Arg Trp Leu Gln Gln Glu Glu Glu 
                645                 650                 655     


Glu Arg Arg His Gln Glu Leu Leu Gln Lys Lys Lys Glu Glu Glu Gln 
            660                 665                 670         


Glu Arg Leu Arg Lys Ala Ala Glu Ala Lys Arg Leu Ala Glu Gln Arg 
        675                 680                 685             


Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu 
    690                 695                 700                 


Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Gln Leu Ala 
705                 710                 715                 720 


Glu Gln Glu Arg Arg Arg Glu Gln Glu Arg Leu Gln Ala Glu Arg Glu 
                725                 730                 735     


Leu Gln Glu Arg Glu Lys Ala Leu Arg Leu Gln Lys Glu Gln Leu Gln 
            740                 745                 750         


Arg Glu Leu Glu Glu Lys Lys Lys Lys Glu Glu Gln Gln Arg Leu Ala 
        755                 760                 765             


Glu Arg Gln Leu Gln Glu Glu Gln Glu Lys Lys Ala Lys Glu Ala Ala 
    770                 775                 780                 


Gly Ala Ser Lys Ala Leu Asn Val Thr Val Asp Val Gln Ser Pro Ala 
785                 790                 795                 800 


Cys Thr Ser Tyr Gln Met Thr Pro Gln Gly His Arg Ala Pro Pro Lys 
                805                 810                 815     


Ile Asn Pro Asp Asn Tyr Gly Met Asp Leu Asn Ser Asp Asp Ser Thr 
            820                 825                 830         


Asp Asp Glu Ala His Pro Arg Lys Pro Ile Pro Thr Trp Ala Arg Gly 
        835                 840                 845             


Thr Pro Leu Ser Gln Ala Ile Ile His Gln Tyr Tyr His Pro Pro Asn 
    850                 855                 860                 


Leu Leu Glu Leu Phe Gly Thr Ile Leu Pro Leu Asp Leu Glu Asp Ile 
865                 870                 875                 880 


Phe Lys Lys Ser Lys Pro Arg Tyr His Lys Arg Thr Ser Ser Ala Val 
                885                 890                 895     


Trp Asn Ser Pro Pro Leu Gln Gly Ala Arg Val Pro Ser Ser Leu Ala 
            900                 905                 910         


Tyr Ser Leu Lys Lys His 
        915             


<210> 6882
<211> 575
<212> PRT
<213> Homo sapiens

<400> 6882
Met Thr Ser Lys Lys Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp 
1               5                   10                  15      


Ala Leu Ala Gly Leu Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln 
            20                  25                  30          


Gly His Arg Val Ala Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg 
        35                  40                  45              


Val Ala Leu Leu Ser Gly Gly Gly Ser Gly His Glu Pro Ala His Ala 
    50                  55                  60                  


Gly Phe Ile Gly Lys Gly Met Leu Thr Gly Val Ile Ala Gly Ala Val 
65                  70                  75                  80  


Phe Thr Ser Pro Ala Val Gly Ser Ile Leu Ala Ala Ile Arg Ala Val 
                85                  90                  95      


Ala Gln Ala Gly Thr Val Gly Thr Leu Leu Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Arg Leu Asn Phe Gly Leu Ala Arg Glu Gln Ala Arg Ala Glu 
        115                 120                 125             


Gly Ile Pro Val Glu Met Val Val Ile Gly Asp Asp Ser Ala Phe Thr 
    130                 135                 140                 


Val Leu Lys Lys Ala Gly Arg Arg Gly Leu Cys Gly Thr Val Leu Ile 
145                 150                 155                 160 


His Lys Val Ala Gly Ala Leu Ala Glu Ala Gly Val Gly Leu Glu Glu 
                165                 170                 175     


Ile Ala Lys Gln Val Asn Val Val Ala Lys Ala Met Gly Thr Leu Gly 
            180                 185                 190         


Val Ser Leu Ser Ser Cys Ser Val Pro Gly Ser Lys Pro Thr Phe Glu 
        195                 200                 205             


Leu Ser Ala Asp Glu Val Glu Leu Gly Leu Gly Ile His Gly Glu Ala 
    210                 215                 220                 


Gly Val Arg Arg Ile Lys Met Ala Thr Ala Asp Glu Ile Val Lys Leu 
225                 230                 235                 240 


Met Leu Asp His Met Thr Asn Thr Thr Asn Ala Ser His Val Pro Val 
                245                 250                 255     


Gln Pro Gly Ser Ser Val Val Met Met Val Asn Asn Leu Gly Gly Leu 
            260                 265                 270         


Ser Phe Leu Glu Leu Gly Ile Ile Ala Asp Ala Thr Val Arg Ser Leu 
        275                 280                 285             


Glu Gly Arg Gly Val Lys Ile Ala Arg Ala Leu Val Gly Thr Phe Met 
    290                 295                 300                 


Ser Ala Leu Glu Met Pro Gly Ile Ser Leu Thr Leu Leu Leu Val Asp 
305                 310                 315                 320 


Glu Pro Leu Leu Lys Leu Ile Asp Ala Glu Thr Thr Ala Ala Ala Trp 
                325                 330                 335     


Pro Asn Val Ala Ala Val Ser Ile Thr Gly Arg Lys Arg Ser Arg Val 
            340                 345                 350         


Ala Pro Ala Glu Pro Gln Glu Ala Pro Asp Ser Thr Ala Ala Gly Gly 
        355                 360                 365             


Ser Ala Ser Lys Arg Met Ala Leu Val Leu Glu Arg Val Cys Ser Thr 
    370                 375                 380                 


Leu Leu Gly Leu Glu Glu His Leu Asn Ala Leu Asp Arg Ala Ala Gly 
385                 390                 395                 400 


Asp Gly Asp Cys Gly Thr Thr His Ser Arg Ala Ala Arg Ala Ile Gln 
                405                 410                 415     


Glu Trp Leu Lys Glu Gly Pro Pro Pro Ala Ser Pro Ala Gln Leu Leu 
            420                 425                 430         


Ser Lys Leu Ser Val Leu Leu Leu Glu Lys Met Gly Gly Ser Ser Gly 
        435                 440                 445             


Ala Leu Tyr Gly Leu Phe Leu Thr Ala Ala Ala Gln Pro Leu Lys Ala 
    450                 455                 460                 


Lys Thr Ser Leu Pro Ala Trp Ser Ala Ala Met Asp Ala Gly Leu Glu 
465                 470                 475                 480 


Ala Met Gln Lys Tyr Gly Lys Ala Ala Pro Gly Asp Arg Thr Met Leu 
                485                 490                 495     


Asp Ser Leu Trp Ala Ala Gly Gln Glu Leu Gln Ala Trp Lys Ser Pro 
            500                 505                 510         


Gly Ala Asp Leu Leu Gln Val Leu Thr Lys Ala Val Lys Ser Ala Glu 
        515                 520                 525             


Ala Ala Ala Glu Ala Thr Lys Asn Met Glu Ala Gly Ala Gly Arg Ala 
    530                 535                 540                 


Ser Tyr Ile Ser Ser Ala Arg Leu Glu Gln Pro Asp Pro Gly Ala Val 
545                 550                 555                 560 


Ala Ala Ala Ala Ile Leu Arg Ala Ile Leu Glu Val Leu Gln Ser 
                565                 570                 575 


<210> 6883
<211> 359
<212> PRT
<213> Homo sapiens

<400> 6883
Met Ala Ala Pro Cys Ala Glu Asp Pro Ser Leu Glu Arg His Phe Lys 
1               5                   10                  15      


Gly His Arg Asp Ala Val Thr Cys Val Asp Phe Ser Ile Asn Thr Lys 
            20                  25                  30          


Gln Leu Ala Ser Gly Ser Met Asp Ser Cys Leu Met Val Trp His Met 
        35                  40                  45              


Lys Pro Gln Ser Arg Ala Tyr Arg Phe Thr Gly His Lys Asp Ala Val 
    50                  55                  60                  


Thr Cys Val Asn Phe Ser Pro Ser Gly His Leu Leu Ala Ser Gly Ser 
65                  70                  75                  80  


Arg Asp Lys Thr Val Arg Ile Trp Val Pro Asn Val Lys Gly Glu Ser 
                85                  90                  95      


Thr Val Phe Arg Ala His Thr Ala Thr Val Arg Ser Val His Phe Cys 
            100                 105                 110         


Ser Asp Gly Gln Ser Phe Val Thr Ala Ser Asp Asp Lys Thr Val Lys 
        115                 120                 125             


Val Trp Ala Thr His Arg Gln Lys Phe Leu Phe Ser Leu Ser Gln His 
    130                 135                 140                 


Ile Asn Trp Val Arg Cys Ala Lys Phe Ser Pro Asp Gly Arg Leu Ile 
145                 150                 155                 160 


Val Ser Ala Ser Asp Asp Lys Thr Val Lys Leu Trp Asp Lys Ser Ser 
                165                 170                 175     


Arg Glu Cys Val His Ser Tyr Cys Glu His Gly Gly Phe Val Thr Tyr 
            180                 185                 190         


Val Asp Phe His Pro Ser Gly Thr Cys Ile Ala Ala Ala Gly Met Asp 
        195                 200                 205             


Asn Thr Val Lys Val Trp Asp Val Arg Thr His Arg Leu Leu Gln His 
    210                 215                 220                 


Tyr Gln Leu His Ser Ala Ala Val Asn Gly Leu Ser Phe His Pro Ser 
225                 230                 235                 240 


Gly Asn Tyr Leu Ile Thr Ala Ser Ser Asp Ser Thr Leu Lys Ile Leu 
                245                 250                 255     


Asp Leu Met Glu Gly Arg Leu Leu Tyr Thr Leu His Gly His Gln Gly 
            260                 265                 270         


Pro Ala Thr Thr Val Ala Phe Ser Arg Thr Gly Glu Tyr Phe Ala Ser 
        275                 280                 285             


Gly Gly Ser Asp Glu Gln Val Met Val Trp Lys Ser Asn Phe Asp Ile 
    290                 295                 300                 


Val Asp His Gly Glu Val Thr Lys Val Pro Arg Pro Pro Ala Thr Leu 
305                 310                 315                 320 


Ala Ser Ser Met Gly Asn Leu Thr Val Ser Ile Leu Glu Gln Arg Leu 
                325                 330                 335     


Thr Leu Thr Glu Asp Lys Leu Lys Gln Cys Leu Glu Asn Gln Gln Leu 
            340                 345                 350         


Ile Met Gln Arg Ala Thr Pro 
        355                 


<210> 6884
<211> 210
<212> PRT
<213> Homo sapiens

<400> 6884
Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu 
            100                 105                 110         


Ser Gly Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu 
        115                 120                 125             


Pro Gly Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala 
    130                 135                 140                 


Ala Asn Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp 
145                 150                 155                 160 


Gln Asp Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro 
                165                 170                 175     


Asn His Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu 
            180                 185                 190         


Asp Lys Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly 
        195                 200                 205             


Leu Gln 
    210 


<210> 6885
<211> 496
<212> PRT
<213> Homo sapiens

<400> 6885
Met Asp Gln Asp Tyr Glu Arg Arg Leu Leu Arg Gln Ile Val Ile Gln 
1               5                   10                  15      


Asn Glu Asn Thr Met Pro Arg Val Thr Glu Met Arg Arg Thr Leu Thr 
            20                  25                  30          


Pro Ala Ser Ser Pro Val Ser Ser Pro Ser Lys His Gly Asp Arg Phe 
        35                  40                  45              


Ile Pro Ser Arg Ala Gly Ala Asn Trp Ser Val Asn Phe His Arg Ile 
    50                  55                  60                  


Asn Glu Asn Glu Lys Ser Pro Ser Gln Asn Arg Lys Ala Lys Asp Ala 
65                  70                  75                  80  


Thr Ser Asp Asn Gly Lys Asp Gly Leu Ala Tyr Ser Ala Leu Leu Lys 
                85                  90                  95      


Asn Glu Leu Leu Gly Ala Gly Ile Glu Lys Val Gln Asp Pro Gln Thr 
            100                 105                 110         


Glu Asp Arg Arg Leu Gln Pro Ser Thr Pro Glu Lys Lys Gly Leu Phe 
        115                 120                 125             


Thr Tyr Ser Leu Ser Thr Lys Arg Ser Ser Pro Asp Asp Gly Asn Asp 
    130                 135                 140                 


Val Ser Pro Tyr Ser Leu Ser Pro Val Ser Asn Lys Ser Gln Lys Leu 
145                 150                 155                 160 


Leu Arg Ser Pro Arg Lys Pro Thr Arg Lys Ile Ser Lys Ile Pro Phe 
                165                 170                 175     


Lys Val Leu Asp Ala Pro Glu Leu Gln Asp Asp Phe Tyr Leu Asn Leu 
            180                 185                 190         


Val Asp Trp Ser Ser Leu Asn Val Leu Ser Val Gly Leu Gly Thr Cys 
        195                 200                 205             


Val Tyr Leu Trp Ser Ala Cys Thr Ser Gln Val Thr Arg Leu Cys Asp 
    210                 215                 220                 


Leu Ser Val Glu Gly Asp Ser Val Thr Ser Val Gly Trp Ser Glu Arg 
225                 230                 235                 240 


Gly Asn Leu Val Ala Val Gly Thr His Lys Gly Phe Val Gln Ile Trp 
                245                 250                 255     


Asp Ala Ala Ala Gly Lys Lys Leu Ser Met Leu Glu Gly His Thr Ala 
            260                 265                 270         


Arg Val Gly Ala Leu Ala Trp Asn Ala Glu Gln Leu Ser Ser Gly Ser 
        275                 280                 285             


Arg Asp Arg Met Ile Leu Gln Arg Asp Ile Arg Thr Pro Pro Leu Gln 
    290                 295                 300                 


Ser Glu Arg Arg Leu Gln Gly His Arg Gln Glu Val Cys Gly Leu Lys 
305                 310                 315                 320 


Trp Ser Thr Asp His Gln Leu Leu Ala Ser Gly Gly Asn Asp Asn Lys 
                325                 330                 335     


Leu Leu Val Trp Asn His Ser Ser Leu Ser Pro Val Gln Gln Tyr Thr 
            340                 345                 350         


Glu His Leu Ala Ala Val Lys Ala Ile Ala Trp Ser Pro His Gln His 
        355                 360                 365             


Gly Leu Leu Ala Ser Gly Gly Gly Thr Ala Asp Arg Cys Ile Arg Phe 
    370                 375                 380                 


Trp Asn Thr Leu Thr Gly Gln Pro Leu Gln Cys Ile Asp Thr Gly Ser 
385                 390                 395                 400 


Gln Val Cys Asn Leu Ala Trp Ser Lys His Ala Asn Glu Leu Val Ser 
                405                 410                 415     


Thr His Gly Tyr Ser Gln Asn Gln Ile Leu Val Trp Lys Tyr Pro Ser 
            420                 425                 430         


Leu Thr Gln Val Ala Lys Leu Thr Gly His Ser Tyr Arg Val Leu Tyr 
        435                 440                 445             


Leu Ala Met Ser Pro Asp Gly Glu Ala Ile Val Thr Gly Ala Gly Asp 
    450                 455                 460                 


Glu Thr Leu Arg Phe Trp Asn Val Phe Ser Lys Thr Arg Ser Thr Lys 
465                 470                 475                 480 


Val Lys Trp Glu Ser Val Ser Val Leu Asn Leu Phe Thr Arg Ile Arg 
                485                 490                 495     


<210> 6886
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6886
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 6887
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6887
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 6888
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6888
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 6889
<211> 117
<212> PRT
<213> Homo sapiens

<400> 6889
Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Ile Leu Lys Val 
65                  70                  75                  80  


Cys Gln Ile Ser Arg Leu Tyr Arg Leu Leu Val Val Thr Ile Ile His 
                85                  90                  95      


Leu His Phe Leu Lys Gln Val Lys Ser Ser Val Gly Asp Arg Ile Asn 
            100                 105                 110         


Met Ala Asn Trp Val 
        115         


<210> 6890
<211> 1057
<212> PRT
<213> Homo sapiens

<400> 6890
Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 
65                  70                  75                  80  


Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 
                85                  90                  95      


Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 
        115                 120                 125             


Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 
    130                 135                 140                 


Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 
145                 150                 155                 160 


Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 
                165                 170                 175     


Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 
            180                 185                 190         


Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 
        195                 200                 205             


Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 
    210                 215                 220                 


Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 
225                 230                 235                 240 


Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 
                245                 250                 255     


Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 
            260                 265                 270         


Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 
        275                 280                 285             


Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 
305                 310                 315                 320 


Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 
                325                 330                 335     


Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 
            340                 345                 350         


Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 
    370                 375                 380                 


Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 
385                 390                 395                 400 


Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 
                405                 410                 415     


Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 
            420                 425                 430         


Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 
        435                 440                 445             


Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 
    450                 455                 460                 


Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 
465                 470                 475                 480 


Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 
                485                 490                 495     


Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 
            500                 505                 510         


Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 
        515                 520                 525             


Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 
    530                 535                 540                 


Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 
545                 550                 555                 560 


Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 
                565                 570                 575     


Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 
            580                 585                 590         


Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 
        595                 600                 605             


Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 
    610                 615                 620                 


Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 
625                 630                 635                 640 


Gly Met Asp Val Asn His Gly Leu Thr Glu Leu Ala Asp Ile Pro Val 
                645                 650                 655     


Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr Thr 
            660                 665                 670         


Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp Gln 
        675                 680                 685             


Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu Ser 
    690                 695                 700                 


Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val Gly 
705                 710                 715                 720 


Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys Lys 
                725                 730                 735     


Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly Gly 
            740                 745                 750         


Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp Pro 
        755                 760                 765             


Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp Phe 
    770                 775                 780                 


Ser Asp Lys Thr Phe Glu Asp Ser Asp Leu Phe His Leu Ile Gly Val 
785                 790                 795                 800 


Ile Cys Gly Leu Ala Ile Tyr Asn Cys Thr Ile Val Asp Leu His Phe 
                805                 810                 815     


Pro Leu Ala Leu Tyr Lys Lys Leu Leu Lys Lys Lys Pro Ser Leu Asp 
            820                 825                 830         


Asp Leu Lys Glu Leu Met Pro Asp Val Gly Arg Ser Met Gln Gln Leu 
        835                 840                 845             


Leu Asp Tyr Pro Glu Asp Asp Ile Glu Glu Thr Phe Cys Leu Asn Phe 
    850                 855                 860                 


Thr Ile Thr Val Glu Asn Phe Gly Ala Thr Glu Val Lys Glu Leu Val 
865                 870                 875                 880 


Leu Asn Gly Ala Asp Thr Ala Val Asn Lys Gln Asn Arg Gln Glu Phe 
                885                 890                 895     


Val Asp Ala Tyr Val Asp Tyr Ile Phe Asn Lys Ser Val Ala Ser Leu 
            900                 905                 910         


Phe Asp Ala Phe His Ala Gly Phe His Lys Val Cys Gly Gly Lys Val 
        915                 920                 925             


Leu Leu Leu Phe Gln Pro Asn Glu Leu Gln Ala Met Val Ile Gly Asn 
    930                 935                 940                 


Thr Asn Tyr Asp Trp Lys Glu Leu Glu Lys Asn Thr Glu Tyr Lys Gly 
945                 950                 955                 960 


Glu Tyr Trp Ala Glu His Pro Thr Ile Lys Ile Phe Trp Glu Val Phe 
                965                 970                 975     


His Glu Leu Pro Leu Glu Lys Lys Lys Gln Phe Leu Leu Phe Leu Thr 
            980                 985                 990         


Gly Ser Asp Arg Ile Pro Ile Leu  Gly Met Lys Ser Leu  Lys Leu Val 
        995                 1000                 1005             


Ile Gln  Ser Thr Gly Gly Gly  Glu Glu Tyr Leu Pro  Val Ser His 
    1010                 1015                 1020             


Thr Cys  Phe Asn Leu Leu Asp  Leu Pro Lys Tyr Thr  Glu Lys Glu 
    1025                 1030                 1035             


Thr Leu  Arg Ser Lys Leu Ile  Gln Ala Ile Asp His  Asn Glu Gly 
    1040                 1045                 1050             


Phe Ser  Leu Ile 
    1055         


<210> 6891
<211> 359
<212> PRT
<213> Homo sapiens

<400> 6891
Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
1               5                   10                  15      


Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
            20                  25                  30          


Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
        35                  40                  45              


Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
    50                  55                  60                  


Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
65                  70                  75                  80  


Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Val Trp 
                85                  90                  95      


Val Pro Lys Gln Lys Pro Leu Asp Pro Val Leu Glu Ser Val Thr Leu 
            100                 105                 110         


Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
        115                 120                 125             


Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
    130                 135                 140                 


Gln Tyr Tyr Gln Ala Leu Ser Ser Ser Ser Ile Met Asn Lys Glu Gly 
145                 150                 155                 160 


Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                165                 170                 175     


Glu Pro Asn Ser Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
            180                 185                 190         


Asn Asp Pro Lys Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
        195                 200                 205             


Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ala Leu Lys Glu Asn Ser 
    210                 215                 220                 


Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
225                 230                 235                 240 


Ala Tyr Ala Leu Ala Glu Met Leu Lys Glu Asn Lys Val Leu Lys Thr 
                245                 250                 255     


Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Arg Leu 
            260                 265                 270         


Val Glu Ala Leu Pro Tyr Asn Thr Ser Leu Val Glu Met Lys Ile Asp 
        275                 280                 285             


Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Ser 
    290                 295                 300                 


Met Leu Glu Lys Asn Ala Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
305                 310                 315                 320 


Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                325                 330                 335     


Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
            340                 345                 350         


Pro Lys Cys Arg Ser Gly Val 
        355                 


<210> 6892
<211> 237
<212> PRT
<213> Homo sapiens

<400> 6892
Met Glu Val Met Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg 
1               5                   10                  15      


Arg Ala Asp Arg Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser 
            20                  25                  30          


Cys His Lys Lys Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr 
        35                  40                  45              


Gln Ser Glu Gln Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His 
    50                  55                  60                  


Met Lys Gln Leu Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg 
65                  70                  75                  80  


Glu Glu Arg Leu Lys Ala Gln Gln Asn Thr Val Leu Tyr Leu Leu Gln 
                85                  90                  95      


Gln Lys Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala Pro Lys 
            100                 105                 110         


Asp Asp Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala Asp Leu 
        115                 120                 125             


Lys Arg His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu Arg Lys 
    130                 135                 140                 


Glu Asn Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys Gly Pro 
145                 150                 155                 160 


Ile Glu Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr Ser Glu 
                165                 170                 175     


Leu Trp Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser Ser Thr 
            180                 185                 190         


Trp Gln Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile Pro Ile 
        195                 200                 205             


Pro Asn Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro Leu Met 
    210                 215                 220                 


Glu Leu Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn 
225                 230                 235         


<210> 6893
<211> 485
<212> PRT
<213> Homo sapiens

<400> 6893
Met Asn Gly Thr Leu Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu 
            20                  25                  30          


Arg Glu Leu Phe Glu Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Met Lys Val Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Asn Asn Val Glu Asp Arg Lys Leu Phe Ile Gly 
            100                 105                 110         


Met Ile Ser Lys Lys Cys Thr Glu Asn Asp Ile Arg Val Met Phe Ser 
        115                 120                 125             


Ser Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp Gly 
    130                 135                 140                 


Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Thr Thr Arg Ala Met Ala 
145                 150                 155                 160 


Gln Thr Ala Ile Lys Ala Met His Gln Ala Gln Thr Met Glu Gly Cys 
                165                 170                 175     


Ser Ser Pro Met Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys Glu 
            180                 185                 190         


Gln Lys Arg Met Ala Gln Gln Leu Gln Gln Gln Met Gln Gln Ile Ser 
        195                 200                 205             


Ala Ala Ser Val Trp Gly Asn Leu Ala Gly Leu Asn Thr Leu Gly Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Tyr Leu Gln Leu Leu Gln Gln Thr Ala Ser Ser 
225                 230                 235                 240 


Gly Asn Leu Asn Thr Leu Ser Ser Leu His Pro Met Gly Gly Leu Asn 
                245                 250                 255     


Ala Met Gln Leu Gln Asn Leu Ala Ala Leu Ala Ala Ala Ala Ser Ala 
            260                 265                 270         


Ala Gln Asn Thr Pro Ser Gly Thr Asn Ala Leu Thr Thr Ser Ser Ser 
        275                 280                 285             


Pro Leu Ser Val Leu Thr Ser Ser Gly Ser Ser Pro Ser Ser Ser Ser 
    290                 295                 300                 


Ser Asn Ser Val Asn Pro Ile Ala Ser Leu Gly Ala Leu Gln Thr Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Ala Gly Leu Asn Val Gly Ser Leu Ala Gly Met Ala 
                325                 330                 335     


Ala Leu Asn Gly Gly Leu Gly Ser Ser Gly Leu Ser Asn Gly Thr Gly 
            340                 345                 350         


Ser Thr Met Glu Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr 
        355                 360                 365             


Ala Ala Ala Ala Leu Pro Thr Leu Tyr Asn Gln Asn Leu Leu Thr Gln 
    370                 375                 380                 


Gln Ser Ile Gly Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala 
385                 390                 395                 400 


Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln Asp Leu 
                405                 410                 415     


Leu Gln Met Phe Met Pro Phe Gly Asn Val Val Ser Ala Lys Val Phe 
            420                 425                 430         


Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr 
        435                 440                 445             


Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln Ser Met Asn Gly Phe 
    450                 455                 460                 


Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser Lys Asn 
465                 470                 475                 480 


Asp Ser Lys Pro Tyr 
                485 


<210> 6894
<211> 483
<212> PRT
<213> Homo sapiens

<400> 6894
Met Asn Gly Thr Leu Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu 
            20                  25                  30          


Arg Glu Leu Phe Glu Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Met Lys Val Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Asn Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Ile Ser Lys Lys Cys Thr Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Ser Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Thr Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Thr Ala Ile Lys Ala Met His Gln Ala Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Met Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Lys Arg Met Ala Gln Gln Leu Gln Gln Gln Met Gln Gln Ile 
        195                 200                 205             


Ser Ala Ala Ser Val Trp Gly Asn Leu Ala Gly Leu Asn Thr Leu Gly 
    210                 215                 220                 


Pro Gln Tyr Leu Ala Leu Leu Gln Gln Thr Ala Ser Ser Gly Asn Leu 
225                 230                 235                 240 


Asn Thr Leu Ser Ser Leu His Pro Met Gly Gly Leu Asn Ala Met Gln 
                245                 250                 255     


Leu Gln Asn Leu Ala Ala Leu Ala Ala Ala Ala Ser Ala Ala Gln Asn 
            260                 265                 270         


Thr Pro Ser Gly Thr Asn Ala Leu Thr Thr Ser Ser Ser Pro Leu Ser 
        275                 280                 285             


Val Leu Thr Ser Ser Ala Gly Ser Ser Pro Ser Ser Ser Ser Ser Asn 
    290                 295                 300                 


Ser Val Asn Pro Ile Ala Ser Leu Gly Ala Leu Gln Thr Leu Ala Gly 
305                 310                 315                 320 


Ala Thr Ala Gly Leu Asn Val Gly Ser Leu Ala Gly Met Ala Ala Leu 
                325                 330                 335     


Asn Gly Gly Leu Gly Ser Ser Gly Leu Ser Asn Gly Thr Gly Ser Thr 
            340                 345                 350         


Met Glu Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala 
        355                 360                 365             


Ala Ala Leu Pro Thr Leu Tyr Asn Gln Asn Leu Leu Thr Gln Gln Ser 
    370                 375                 380                 


Ile Gly Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala Asn Leu 
385                 390                 395                 400 


Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln Asp Leu Leu Gln 
                405                 410                 415     


Met Phe Met Pro Phe Gly Asn Val Val Ser Ala Lys Val Phe Ile Asp 
            420                 425                 430         


Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr Asp Asn 
        435                 440                 445             


Pro Val Ser Ala Gln Ala Ala Ile Gln Ser Met Asn Gly Phe Gln Ile 
    450                 455                 460                 


Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser Lys Asn Asp Ser 
465                 470                 475                 480 


Lys Pro Tyr 
            


<210> 6895
<211> 1189
<212> PRT
<213> Homo sapiens

<400> 6895
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Ser Thr Lys Glu Asp Arg Arg Ser Glu Glu Lys Ala Ala Ala Met 
    530                 535                 540                 


Ala Ala Ser Lys Lys Thr Ala Pro Pro Gly Ser Ala Val Gly Lys Gln 
545                 550                 555                 560 


Pro Ala Pro Arg Asn Leu Val Pro Lys Lys Ser Ser Phe Ala Asn Val 
                565                 570                 575     


Ala Ala Ala Thr Pro Ala Ile Lys Lys Pro Pro Ser Gly Phe Lys Gly 
            580                 585                 590         


Thr Ile Pro Lys Arg Pro Trp Leu Ser Ala Thr Pro Ser Ser Gly Ala 
        595                 600                 605             


Ser Ala Ala Arg Gln Ala Gly Pro Ala Pro Ala Ala Ala Thr Ala Ala 
    610                 615                 620                 


Ser Lys Lys Phe Pro Gly Ser Ala Ala Leu Val Gly Ala Val Arg Lys 
625                 630                 635                 640 


Pro Val Val Pro Ser Val Pro Met Ala Ser Pro Ala Pro Gly Arg Leu 
                645                 650                 655     


Gly Ala Met Ser Ala Ala Pro Ser Gln Pro Asn Ser Gln Ile Arg Gln 
            660                 665                 670         


Asn Ile Arg Arg Ser Leu Lys Glu Ile Leu Trp Lys Arg Val Asn Asp 
        675                 680                 685             


Ser Asp Asp Leu Ile Met Thr Glu Asn Glu Val Gly Lys Ile Ala Leu 
    690                 695                 700                 


His Ile Glu Lys Glu Met Phe Asn Leu Phe Gln Val Thr Asp Asn Arg 
705                 710                 715                 720 


Tyr Lys Ser Lys Tyr Arg Ser Ile Met Phe Asn Leu Lys Asp Pro Lys 
                725                 730                 735     


Asn Gln Gly Leu Phe His Arg Val Leu Arg Glu Glu Ile Ser Leu Ala 
            740                 745                 750         


Lys Leu Val Arg Leu Lys Pro Glu Glu Leu Val Ser Lys Glu Leu Ser 
        755                 760                 765             


Thr Trp Lys Glu Arg Pro Ala Arg Ser Val Met Glu Ser Arg Thr Lys 
    770                 775                 780                 


Leu His Asn Glu Ser Lys Lys Thr Ala Pro Arg Gln Glu Ala Ile Pro 
785                 790                 795                 800 


Asp Leu Glu Asp Ser Pro Pro Val Ser Asp Ser Glu Glu Gln Gln Glu 
                805                 810                 815     


Ser Ala Arg Ala Val Pro Glu Lys Ser Thr Ala Pro Leu Leu Asp Val 
            820                 825                 830         


Phe Ser Ser Met Leu Lys Asp Thr Thr Ser Gln His Arg Ala His Leu 
        835                 840                 845             


Phe Asp Leu Asn Cys Lys Ile Cys Thr Gly Gln Val Pro Ser Ala Glu 
    850                 855                 860                 


Asp Glu Pro Ala Pro Lys Lys Gln Lys Leu Ser Ala Ser Val Lys Lys 
865                 870                 875                 880 


Glu Asp Leu Lys Ser Lys His Asp Ser Ser Ala Pro Asp Pro Ala Pro 
                885                 890                 895     


Asp Ser Ala Asp Glu Val Met Pro Glu Ala Val Pro Glu Val Ala Ser 
            900                 905                 910         


Glu Pro Gly Leu Glu Ser Ala Ser His Pro Asn Val Asp Arg Thr Tyr 
        915                 920                 925             


Phe Pro Gly Pro Pro Gly Asp Gly His Pro Glu Pro Ser Pro Leu Glu 
    930                 935                 940                 


Asp Leu Ser Pro Cys Pro Ala Ser Cys Gly Ser Gly Val Val Thr Thr 
945                 950                 955                 960 


Val Thr Val Ser Gly Arg Asp Pro Arg Thr Ala Pro Ser Ser Ser Cys 
                965                 970                 975     


Thr Ala Val Ala Ser Ala Ala Ser Arg Pro Asp Ser Thr His Met Val 
            980                 985                 990         


Glu Ala Arg Gln Asp Val Pro Lys  Pro Val Leu Thr Ser  Val Met Val 
        995                 1000                 1005             


Pro Lys  Ser Ile Leu Ala Lys  Pro Ser Ser Ser Pro  Asp Pro Arg 
    1010                 1015                 1020             


Tyr Leu  Ser Val Pro Pro Ser  Pro Asn Ile Ser Thr  Ser Glu Ser 
    1025                 1030                 1035             


Arg Ser  Pro Pro Glu Gly Asp  Thr Thr Leu Phe Leu  Ser Arg Leu 
    1040                 1045                 1050             


Ser Thr  Ile Trp Lys Gly Phe  Ile Asn Met Gln Ser  Val Ala Lys 
    1055                 1060                 1065             


Phe Val  Thr Lys Ala Tyr Pro  Val Ser Gly Cys Phe  Asp Tyr Leu 
    1070                 1075                 1080             


Ser Glu  Asp Leu Pro Asp Thr  Ile His Ile Gly Gly  Arg Ile Ala 
    1085                 1090                 1095             


Pro Lys  Thr Val Trp Asp Tyr  Val Gly Lys Leu Lys  Ser Ser Val 
    1100                 1105                 1110             


Ser Lys  Glu Leu Cys Leu Ile  Arg Phe His Pro Ala  Thr Glu Glu 
    1115                 1120                 1125             


Glu Glu  Val Ala Tyr Ile Ser  Leu Tyr Ser Tyr Phe  Ser Ser Arg 
    1130                 1135                 1140             


Gly Arg  Phe Gly Val Val Ala  Asn Asn Asn Arg His  Val Lys Asp 
    1145                 1150                 1155             


Leu Tyr  Leu Ile Pro Leu Ser  Ala Gln Asp Pro Val  Pro Ser Lys 
    1160                 1165                 1170             


Leu Leu  Pro Phe Glu Gly Pro  Gly Lys Arg Arg Leu  Ser Gly Trp 
    1175                 1180                 1185             


Arg 
    


<210> 6896
<211> 1189
<212> PRT
<213> Homo sapiens

<400> 6896
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Ser Thr Lys Glu Asp Arg Arg Ser Glu Glu Lys Ala Ala Ala Met 
    530                 535                 540                 


Ala Ala Ser Lys Lys Thr Ala Pro Pro Gly Ser Ala Val Gly Lys Gln 
545                 550                 555                 560 


Pro Ala Pro Arg Asn Leu Val Pro Lys Lys Ser Ser Phe Ala Asn Val 
                565                 570                 575     


Ala Ala Ala Thr Pro Ala Ile Lys Lys Pro Pro Ser Gly Phe Lys Gly 
            580                 585                 590         


Thr Ile Pro Lys Arg Pro Trp Leu Ser Ala Thr Pro Ser Ser Gly Ala 
        595                 600                 605             


Ser Ala Ala Arg Gln Ala Gly Pro Ala Pro Ala Ala Ala Thr Ala Ala 
    610                 615                 620                 


Ser Lys Lys Phe Pro Gly Ser Ala Ala Leu Val Gly Ala Val Arg Lys 
625                 630                 635                 640 


Pro Val Val Pro Ser Val Pro Met Ala Ser Pro Ala Pro Gly Arg Leu 
                645                 650                 655     


Gly Ala Met Ser Ala Ala Pro Ser Gln Pro Asn Ser Gln Ile Arg Gln 
            660                 665                 670         


Asn Ile Arg Arg Ser Leu Lys Glu Ile Leu Trp Lys Arg Val Asn Asp 
        675                 680                 685             


Ser Asp Asp Leu Ile Met Thr Glu Asn Glu Val Gly Lys Ile Ala Leu 
    690                 695                 700                 


His Ile Glu Lys Glu Met Phe Asn Leu Phe Gln Val Thr Asp Asn Arg 
705                 710                 715                 720 


Tyr Lys Ser Lys Tyr Arg Ser Ile Met Phe Asn Leu Lys Asp Pro Lys 
                725                 730                 735     


Asn Gln Gly Leu Phe His Arg Val Leu Arg Glu Glu Ile Ser Leu Ala 
            740                 745                 750         


Lys Leu Val Arg Leu Lys Pro Glu Glu Leu Val Ser Lys Glu Leu Ser 
        755                 760                 765             


Thr Trp Lys Glu Arg Pro Ala Arg Ser Val Met Glu Ser Arg Thr Lys 
    770                 775                 780                 


Leu His Asn Glu Ser Lys Lys Thr Ala Pro Arg Gln Glu Ala Ile Pro 
785                 790                 795                 800 


Asp Leu Glu Asp Ser Pro Pro Val Ser Asp Ser Glu Glu Gln Gln Glu 
                805                 810                 815     


Ser Ala Arg Ala Val Pro Glu Lys Ser Thr Ala Pro Leu Leu Asp Val 
            820                 825                 830         


Phe Ser Ser Met Leu Lys Asp Thr Thr Ser Gln His Arg Ala His Leu 
        835                 840                 845             


Phe Asp Leu Asn Cys Lys Ile Cys Thr Gly Gln Val Pro Ser Ala Glu 
    850                 855                 860                 


Asp Glu Pro Ala Pro Lys Lys Gln Lys Leu Ser Ala Ser Val Lys Lys 
865                 870                 875                 880 


Glu Asp Leu Lys Ser Lys His Asp Ser Ser Ala Pro Asp Pro Ala Pro 
                885                 890                 895     


Asp Ser Ala Asp Glu Val Met Pro Glu Ala Val Pro Glu Val Ala Ser 
            900                 905                 910         


Glu Pro Gly Leu Glu Ser Ala Ser His Pro Asn Val Asp Arg Thr Tyr 
        915                 920                 925             


Phe Pro Gly Pro Pro Gly Asp Gly His Pro Glu Pro Ser Pro Leu Glu 
    930                 935                 940                 


Asp Leu Ser Pro Cys Pro Ala Ser Cys Gly Ser Gly Val Val Thr Thr 
945                 950                 955                 960 


Val Thr Val Ser Gly Arg Asp Pro Arg Thr Ala Pro Ser Ser Ser Cys 
                965                 970                 975     


Thr Ala Val Ala Ser Ala Ala Ser Arg Pro Asp Ser Thr His Met Val 
            980                 985                 990         


Glu Ala Arg Gln Asp Val Pro Lys  Pro Val Leu Thr Ser  Val Met Val 
        995                 1000                 1005             


Pro Lys  Ser Ile Leu Ala Lys  Pro Ser Ser Ser Pro  Asp Pro Arg 
    1010                 1015                 1020             


Tyr Leu  Ser Val Pro Pro Ser  Pro Asn Ile Ser Thr  Ser Glu Ser 
    1025                 1030                 1035             


Arg Ser  Pro Pro Glu Gly Asp  Thr Thr Leu Phe Leu  Ser Arg Leu 
    1040                 1045                 1050             


Ser Thr  Ile Trp Lys Gly Phe  Ile Asn Met Gln Ser  Val Ala Lys 
    1055                 1060                 1065             


Phe Val  Thr Lys Ala Tyr Pro  Val Ser Gly Cys Phe  Asp Tyr Leu 
    1070                 1075                 1080             


Ser Glu  Asp Leu Pro Asp Thr  Ile His Ile Gly Gly  Arg Ile Ala 
    1085                 1090                 1095             


Pro Lys  Thr Val Trp Asp Tyr  Val Gly Lys Leu Lys  Ser Ser Val 
    1100                 1105                 1110             


Ser Lys  Glu Leu Cys Leu Ile  Arg Phe His Pro Ala  Thr Glu Glu 
    1115                 1120                 1125             


Glu Glu  Val Ala Tyr Ile Ser  Leu Tyr Ser Tyr Phe  Ser Ser Arg 
    1130                 1135                 1140             


Gly Arg  Phe Gly Val Val Ala  Asn Asn Asn Arg His  Val Lys Asp 
    1145                 1150                 1155             


Leu Tyr  Leu Ile Pro Leu Ser  Ala Gln Asp Pro Val  Pro Ser Lys 
    1160                 1165                 1170             


Leu Leu  Pro Phe Glu Gly Pro  Gly Lys Arg Arg Leu  Ser Gly Trp 
    1175                 1180                 1185             


Arg 
    


<210> 6897
<211> 2240
<212> PRT
<213> Homo sapiens

<400> 6897
Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Ser Thr Lys Glu Asp Arg Arg Ser Glu Glu Lys Ala Ala Ala Met 
    530                 535                 540                 


Ala Ala Ser Lys Lys Thr Ala Pro Pro Gly Ser Ala Val Gly Lys Gln 
545                 550                 555                 560 


Pro Ala Pro Arg Asn Leu Val Pro Lys Lys Ser Ser Phe Ala Asn Val 
                565                 570                 575     


Ala Ala Ala Thr Pro Ala Ile Lys Lys Pro Pro Ser Gly Phe Lys Gly 
            580                 585                 590         


Thr Ile Pro Lys Arg Pro Trp Leu Ser Ala Thr Pro Ser Ser Gly Ala 
        595                 600                 605             


Ser Ala Ala Arg Gln Ala Gly Pro Ala Pro Ala Ala Ala Thr Ala Ala 
    610                 615                 620                 


Ser Lys Lys Phe Pro Gly Ser Ala Ala Leu Val Gly Ala Val Arg Lys 
625                 630                 635                 640 


Pro Val Val Pro Ser Val Pro Met Ala Ser Pro Ala Pro Gly Arg Leu 
                645                 650                 655     


Gly Ala Met Ser Ala Ala Pro Ser Gln Pro Asn Ser Gln Ile Arg Gln 
            660                 665                 670         


Asn Ile Arg Arg Ser Leu Lys Glu Ile Leu Trp Lys Arg Val Asn Asp 
        675                 680                 685             


Ser Asp Asp Leu Ile Met Thr Glu Asn Glu Val Gly Lys Ile Ala Leu 
    690                 695                 700                 


His Ile Glu Lys Glu Met Phe Asn Leu Phe Gln Val Thr Asp Asn Arg 
705                 710                 715                 720 


Tyr Lys Ser Lys Tyr Arg Ser Ile Met Phe Asn Leu Lys Asp Pro Lys 
                725                 730                 735     


Asn Gln Gly Leu Phe His Arg Val Leu Arg Glu Glu Ile Ser Leu Ala 
            740                 745                 750         


Lys Leu Val Arg Leu Lys Pro Glu Glu Leu Val Ser Lys Glu Leu Ser 
        755                 760                 765             


Thr Trp Lys Glu Arg Pro Ala Arg Ser Val Met Glu Ser Arg Thr Lys 
    770                 775                 780                 


Leu His Asn Glu Ser Lys Lys Thr Ala Pro Arg Gln Glu Ala Ile Pro 
785                 790                 795                 800 


Asp Leu Glu Asp Ser Pro Pro Val Ser Asp Ser Glu Glu Gln Gln Glu 
                805                 810                 815     


Ser Ala Arg Ala Val Pro Glu Lys Ser Thr Ala Pro Leu Leu Asp Val 
            820                 825                 830         


Phe Ser Ser Met Leu Lys Asp Thr Thr Ser Gln His Arg Ala His Leu 
        835                 840                 845             


Phe Asp Leu Asn Cys Lys Ile Cys Thr Gly Gln Val Pro Ser Ala Glu 
    850                 855                 860                 


Asp Glu Pro Ala Pro Lys Lys Gln Lys Leu Ser Ala Ser Val Lys Lys 
865                 870                 875                 880 


Glu Asp Leu Lys Ser Lys His Asp Ser Ser Ala Pro Asp Pro Ala Pro 
                885                 890                 895     


Asp Ser Ala Asp Glu Val Met Pro Glu Ala Val Pro Glu Val Ala Ser 
            900                 905                 910         


Glu Pro Gly Leu Glu Ser Ala Ser His Pro Asn Val Asp Arg Thr Tyr 
        915                 920                 925             


Phe Pro Gly Pro Pro Gly Asp Gly His Pro Glu Pro Ser Pro Leu Glu 
    930                 935                 940                 


Asp Leu Ser Pro Cys Pro Ala Ser Cys Gly Ser Gly Val Val Thr Thr 
945                 950                 955                 960 


Val Thr Val Ser Gly Arg Asp Pro Arg Thr Ala Pro Ser Ser Ser Cys 
                965                 970                 975     


Thr Ala Val Ala Ser Ala Ala Ser Arg Pro Asp Ser Thr His Met Val 
            980                 985                 990         


Glu Ala Arg Gln Asp Val Pro Lys  Pro Val Leu Thr Ser  Val Met Val 
        995                 1000                 1005             


Pro Lys  Ser Ile Leu Ala Lys  Pro Ser Ser Ser Pro  Asp Pro Arg 
    1010                 1015                 1020             


Tyr Leu  Ser Val Pro Pro Ser  Pro Asn Ile Ser Thr  Ser Glu Ser 
    1025                 1030                 1035             


Arg Ser  Pro Pro Glu Gly Asp  Thr Thr Leu Phe Leu  Ser Arg Leu 
    1040                 1045                 1050             


Ser Thr  Ile Trp Lys Gly Phe  Ile Asn Met Gln Ser  Val Ala Lys 
    1055                 1060                 1065             


Phe Val  Thr Lys Ala Tyr Pro  Val Ser Gly Cys Phe  Asp Tyr Leu 
    1070                 1075                 1080             


Ser Glu  Asp Leu Pro Asp Thr  Ile His Ile Gly Gly  Arg Ile Ala 
    1085                 1090                 1095             


Pro Lys  Thr Val Trp Asp Tyr  Val Gly Lys Leu Lys  Ser Ser Val 
    1100                 1105                 1110             


Ser Lys  Glu Leu Cys Leu Ile  Arg Phe His Pro Ala  Thr Glu Glu 
    1115                 1120                 1125             


Glu Glu  Val Ala Tyr Ile Ser  Leu Tyr Ser Tyr Phe  Ser Ser Arg 
    1130                 1135                 1140             


Gly Arg  Phe Gly Val Val Ala  Asn Asn Asn Arg His  Val Lys Asp 
    1145                 1150                 1155             


Leu Tyr  Leu Ile Pro Leu Ser  Ala Gln Asp Pro Val  Pro Ser Lys 
    1160                 1165                 1170             


Leu Leu  Pro Phe Glu Gly Pro  Gly Leu Glu Ser Pro  Arg Pro Asn 
    1175                 1180                 1185             


Ile Ile  Leu Gly Leu Val Ile  Cys Gln Lys Ile Lys  Arg Pro Ala 
    1190                 1195                 1200             


Asn Ser  Gly Glu Leu Asp Lys  Met Asp Glu Lys Arg  Thr Arg Leu 
    1205                 1210                 1215             


Gln Pro  Glu Glu Ala Asp Val  Pro Ala Tyr Pro Lys  Val Ala Thr 
    1220                 1225                 1230             


Val Pro  Gln Ser Glu Lys Lys  Pro Ser Lys Tyr Pro  Leu Cys Ser 
    1235                 1240                 1245             


Ala Asp  Ala Ala Val Ser Thr  Thr Pro Pro Gly Ser  Pro Pro Pro 
    1250                 1255                 1260             


Pro Pro  Pro Leu Pro Glu Pro  Pro Val Leu Lys Val  Leu Ser Ser 
    1265                 1270                 1275             


Leu Lys  Pro Ala Ala Pro Ser  Pro Ala Thr Ala Ala  Thr Thr Ala 
    1280                 1285                 1290             


Ala Ala  Ala Ser Thr Ala Ala  Ser Ser Thr Ala Ser  Ser Ala Ser 
    1295                 1300                 1305             


Lys Thr  Ala Ser Pro Leu Glu  His Ile Leu Gln Thr  Leu Phe Gly 
    1310                 1315                 1320             


Lys Lys  Lys Ser Phe Asp Pro  Ser Ala Arg Glu Pro  Pro Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gly Leu Pro Gln Glu  Pro Lys Thr Thr Ala  Glu Asp Gly 
    1340                 1345                 1350             


Val Pro  Ala Pro Pro Leu Leu  Asp Pro Ile Val Gln  Gln Phe Gly 
    1355                 1360                 1365             


Gln Phe  Ser Lys Asp Lys Ala  Leu Glu Glu Glu Glu  Asp Asp Arg 
    1370                 1375                 1380             


Pro Tyr  Asp Pro Glu Glu Glu  Tyr Asp Pro Glu Arg  Ala Phe Asp 
    1385                 1390                 1395             


Thr Gln  Leu Val Glu Arg Gly  Arg Arg His Glu Val  Glu Arg Ala 
    1400                 1405                 1410             


Pro Glu  Ala Ala Ala Ala Glu  Arg Glu Glu Val Ala  Tyr Asp Pro 
    1415                 1420                 1425             


Glu Asp  Glu Thr Ile Leu Glu  Glu Ala Lys Val Thr  Val Asp Asp 
    1430                 1435                 1440             


Leu Pro  Asn Arg Met Cys Ala  Asp Val Arg Arg Asn  Ser Val Glu 
    1445                 1450                 1455             


Arg Pro  Ala Glu Pro Val Ala  Gly Ala Ala Thr Pro  Ser Leu Val 
    1460                 1465                 1470             


Glu Gln  Gln Lys Met Leu Glu  Glu Leu Asn Lys Gln  Ile Glu Glu 
    1475                 1480                 1485             


Gln Lys  Arg Gln Leu Glu Glu  Gln Glu Glu Ala Leu  Arg Gln Gln 
    1490                 1495                 1500             


Arg Ala  Ala Val Gly Val Ser  Met Ala His Phe Ser  Val Ser Asp 
    1505                 1510                 1515             


Ala Leu  Met Ser Pro Pro Pro  Lys Ser Ser Leu Pro  Lys Ala Glu 
    1520                 1525                 1530             


Leu Phe  Gln Gln Glu Gln Gln  Ser Ala Asp Lys Pro  Ala Ser Leu 
    1535                 1540                 1545             


Pro Pro  Ala Ser Gln Ala Ser  Asn His Arg Asp Pro  Arg Gln Ala 
    1550                 1555                 1560             


Arg Arg  Leu Ala Thr Glu Thr  Gly Glu Gly Glu Gly  Glu Pro Leu 
    1565                 1570                 1575             


Ser Arg  Leu Ser Ala Arg Gly  Ala Gln Gly Ala Leu  Pro Glu Arg 
    1580                 1585                 1590             


Asp Ala  Ser Arg Gly Gly Leu  Val Gly Gln Ala Pro  Met Pro Val 
    1595                 1600                 1605             


Pro Glu  Glu Lys Glu Pro Ala  Ser Ser Pro Trp Ala  Ser Gly Glu 
    1610                 1615                 1620             


Lys Pro  Pro Ala Gly Ser Glu  Gln Asp Gly Trp Lys  Ala Glu Pro 
    1625                 1630                 1635             


Gly Glu  Gly Thr Arg Pro Ala  Thr Val Gly Asp Ser  Ser Ala Arg 
    1640                 1645                 1650             


Pro Ala  Arg Arg Val Leu Leu  Pro Thr Pro Pro Cys  Gly Ala Leu 
    1655                 1660                 1665             


Gln Pro  Gly Phe Pro Leu Gln  His Asp Gly Glu Arg  Asp Pro Phe 
    1670                 1675                 1680             


Thr Cys  Pro Gly Phe Ala Ser  Gln Asp Lys Ala Leu  Gly Ser Ala 
    1685                 1690                 1695             


Gln Tyr  Glu Asp Pro Arg Asn  Leu His Ser Ala Gly  Arg Ser Ser 
    1700                 1705                 1710             


Ser Pro  Ala Gly Glu Thr Glu  Gly Asp Arg Glu Pro  Gln Ala Arg 
    1715                 1720                 1725             


Pro Gly  Glu Gly Thr Ala Pro  Leu Pro Pro Pro Gly  Gln Lys Val 
    1730                 1735                 1740             


Gly Gly  Ser Gln Pro Pro Phe  Gln Gly Gln Arg Glu  Pro Gly Pro 
    1745                 1750                 1755             


His Ala  Leu Gly Met Ser Gly  Leu His Gly Pro Asn  Phe Pro Gly 
    1760                 1765                 1770             


Pro Arg  Gly Pro Ala Pro Pro  Phe Pro Glu Glu Asn  Ile Ala Ser 
    1775                 1780                 1785             


Asn Asp  Gly Pro Arg Gly Pro  Pro Pro Ala Arg Phe  Gly Ala Gln 
    1790                 1795                 1800             


Lys Gly  Pro Ile Pro Ser Leu  Phe Ser Gly Gln His  Gly Pro Pro 
    1805                 1810                 1815             


Pro Tyr  Gly Asp Ser Arg Gly  Pro Ser Pro Ser Tyr  Leu Gly Gly 
    1820                 1825                 1830             


Pro Arg  Gly Val Ala Pro Ser  Gln Phe Glu Glu Arg  Lys Asp Pro 
    1835                 1840                 1845             


His Gly  Glu Lys Arg Glu Phe  Gln Asp Ala Pro Tyr  Asn Glu Val 
    1850                 1855                 1860             


Thr Gly  Ala Pro Ala Gln Phe  Glu Gly Thr Glu Gln  Ala Pro Phe 
    1865                 1870                 1875             


Leu Gly  Ser Arg Gly Gly Ala  Pro Phe Gln Phe Gly  Gly Gln Arg 
    1880                 1885                 1890             


Arg Pro  Leu Leu Ser Gln Leu  Lys Gly Pro Arg Gly  Gly Pro Pro 
    1895                 1900                 1905             


Pro Ser  Gln Phe Gly Gly Gln  Arg Gly Pro Pro Pro  Gly His Phe 
    1910                 1915                 1920             


Val Gly  Pro Arg Gly Pro His  Pro Ser Gln Phe Glu  Thr Ala Arg 
    1925                 1930                 1935             


Gly Pro  His Pro Asn Gln Phe  Glu Gly Pro Arg Gly  Gln Ala Pro 
    1940                 1945                 1950             


Asn Phe  Met Pro Gly Pro Arg  Gly Ile Gln Pro Gln  Gln Phe Glu 
    1955                 1960                 1965             


Asp Gln  Arg Val His Ser Pro  Pro Arg Phe Thr Asn  Gln Arg Ala 
    1970                 1975                 1980             


Pro Ala  Pro Leu Gln Phe Gly  Gly Leu Arg Gly Ser  Ala Pro Phe 
    1985                 1990                 1995             


Ser Glu  Lys Asn Glu Gln Thr  Pro Ser Arg Phe His  Phe Gln Gly 
    2000                 2005                 2010             


Gln Ala  Pro Gln Val Met Lys  Pro Gly Pro Arg Pro  Leu Leu Glu 
    2015                 2020                 2025             


Leu Pro  Ser His Pro Pro Gln  His Arg Lys Asp Arg  Trp Glu Glu 
    2030                 2035                 2040             


Ala Gly  Pro Pro Ser Ala Leu  Ser Ser Ser Ala Pro  Gly Gln Gly 
    2045                 2050                 2055             


Pro Glu  Ala Asp Gly Gln Trp  Ala Ser Ala Asp Phe  Arg Glu Gly 
    2060                 2065                 2070             


Lys Gly  His Glu Tyr Arg Asn  Gln Thr Phe Glu Gly  Arg Gln Arg 
    2075                 2080                 2085             


Glu Arg  Phe Asp Val Gly Pro  Lys Glu Lys Pro Leu  Glu Glu Pro 
    2090                 2095                 2100             


Asp Ala  Gln Gly Arg Ala Ser  Glu Asp Arg Arg Arg  Glu Arg Glu 
    2105                 2110                 2115             


Arg Gly  Arg Asn Trp Ser Arg  Glu Arg Asp Trp Asp  Arg Pro Arg 
    2120                 2125                 2130             


Glu Trp  Asp Arg His Arg Asp  Lys Asp Ser Ser Arg  Asp Trp Asp 
    2135                 2140                 2145             


Arg Asn  Arg Glu Arg Ser Ala  Asn Arg Asp Arg Glu  Arg Glu Ala 
    2150                 2155                 2160             


Asp Arg  Gly Lys Glu Trp Asp  Arg Ser Arg Glu Arg  Ser Arg Asn 
    2165                 2170                 2175             


Arg Glu  Arg Glu Arg Asp Arg  Arg Arg Asp Arg Asp  Arg Ser Arg 
    2180                 2185                 2190             


Ser Arg  Glu Arg Asp Arg Asp  Lys Ala Arg Asp Arg  Glu Arg Gly 
    2195                 2200                 2205             


Arg Asp  Arg Lys Asp Arg Ser  Lys Ser Lys Glu Ser  Ala Arg Asp 
    2210                 2215                 2220             


Pro Lys  Pro Glu Ala Ser Arg  Ala Ser Asp Ala Gly  Thr Ala Ser 
    2225                 2230                 2235             


Gln Ala  
    2240 


<210> 6898
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6898
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg 
    130                 135                 140                 


Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210> 6899
<211> 277
<212> PRT
<213> Homo sapiens

<400> 6899
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala 
65                  70                  75                  80  


Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp 
                85                  90                  95      


Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile 
            100                 105                 110         


Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg 
        115                 120                 125             


Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met 
    130                 135                 140                 


Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln 
145                 150                 155                 160 


Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu 
                165                 170                 175     


Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Arg Val Phe Gln Lys Leu 
            180                 185                 190         


Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg 
        195                 200                 205             


Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu 
    210                 215                 220                 


Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro 
225                 230                 235                 240 


Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly 
                245                 250                 255     


Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly 
            260                 265                 270         


Asp Val Asn Leu Pro 
        275         


<210> 6900
<211> 414
<212> PRT
<213> Homo sapiens

<400> 6900
Met Gly Thr Val Thr Glu Asp Leu Ile Arg Arg Asn Ala Glu His Asn 
1               5                   10                  15      


Asp Cys Val Ile Phe Ser Leu Glu Glu Leu Ser Leu His Gln Gln Glu 
            20                  25                  30          


Ile Glu Arg Leu Glu His Ile Asp Lys Trp Cys Arg Asp Leu Lys Ile 
        35                  40                  45              


Leu Tyr Leu Gln Asn Asn Leu Ile Gly Lys Ile Glu Asn Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Leu Glu Tyr Leu Asn Leu Ala Leu Asn Asn Ile Glu Lys 
65                  70                  75                  80  


Ile Glu Asn Leu Glu Gly Cys Glu Glu Leu Ala Lys Leu Asp Leu Thr 
                85                  90                  95      


Val Asn Phe Ile Gly Glu Leu Ser Ser Ile Lys Asn Leu Gln His Asn 
            100                 105                 110         


Ile His Leu Lys Glu Leu Phe Leu Met Gly Asn Pro Cys Ala Ser Phe 
        115                 120                 125             


Asp His Tyr Arg Glu Phe Val Val Ala Thr Leu Pro Gln Leu Lys Trp 
    130                 135                 140                 


Leu Asp Gly Lys Glu Ile Glu Pro Ser Glu Arg Ile Lys Ala Leu Gln 
145                 150                 155                 160 


Asp Tyr Ser Val Ile Glu Pro Gln Ile Arg Glu Gln Glu Lys Asp His 
                165                 170                 175     


Cys Leu Lys Arg Ala Lys Leu Lys Glu Glu Ala Gln Arg Lys His Gln 
            180                 185                 190         


Glu Glu Asp Lys Asn Glu Asp Lys Arg Ser Asn Ala Gly Phe Asp Gly 
        195                 200                 205             


Arg Trp Tyr Thr Asp Ile Asn Ala Thr Leu Ser Ser Leu Glu Ser Lys 
    210                 215                 220                 


Asp His Leu Gln Ala Pro Asp Thr Glu Glu His Asn Thr Lys Lys Leu 
225                 230                 235                 240 


Asp Asn Ser Glu Asp Asp Leu Glu Phe Trp Asn Lys Pro Cys Leu Phe 
                245                 250                 255     


Thr Pro Glu Ser Arg Leu Glu Thr Leu Arg His Met Glu Lys Gln Arg 
            260                 265                 270         


Lys Lys Gln Glu Lys Leu Ser Glu Lys Lys Lys Lys Val Lys Pro Pro 
        275                 280                 285             


Arg Thr Leu Ile Thr Glu Asp Gly Lys Ala Leu Asn Val Asn Glu Pro 
    290                 295                 300                 


Lys Ile Asp Phe Ser Leu Lys Asp Asn Glu Lys Gln Ile Ile Leu Asp 
305                 310                 315                 320 


Leu Ala Val Tyr Arg Tyr Met Asp Thr Ser Leu Ile Asp Val Asp Val 
                325                 330                 335     


Gln Pro Thr Tyr Val Arg Val Met Ile Lys Gly Lys Pro Phe Gln Leu 
            340                 345                 350         


Val Leu Pro Ala Glu Val Lys Pro Asp Ser Ser Ser Ala Lys Arg Ser 
        355                 360                 365             


Gln Thr Thr Gly His Leu Val Ile Cys Met Pro Lys Val Gly Glu Val 
    370                 375                 380                 


Ile Thr Gly Gly Gln Arg Ala Phe Lys Ser Met Lys Thr Thr Ser Asp 
385                 390                 395                 400 


Arg Ser Arg Glu Gln Thr Asn Thr Ser Tyr Ser Thr Gly Phe 
                405                 410                 


<210> 6901
<211> 842
<212> PRT
<213> Homo sapiens

<400> 6901
Met Ser Ser Ser His Phe Ala Ser Arg His Arg Lys Asp Ile Ser Thr 
1               5                   10                  15      


Glu Met Ile Arg Thr Lys Ile Ala His Arg Lys Ser Leu Ser Gln Lys 
            20                  25                  30          


Glu Asn Arg His Lys Glu Tyr Glu Arg Asn Arg His Phe Gly Leu Lys 
        35                  40                  45              


Asp Val Asn Ile Pro Thr Leu Glu Gly Arg Ile Leu Val Glu Leu Asp 
    50                  55                  60                  


Glu Thr Ser Gln Gly Leu Val Pro Glu Lys Thr Asn Val Lys Pro Arg 
65                  70                  75                  80  


Ala Met Lys Thr Ile Leu Gly Asp Gln Arg Lys Gln Met Leu Gln Lys 
                85                  90                  95      


Tyr Lys Glu Glu Lys Gln Leu Gln Lys Leu Lys Glu Gln Arg Glu Lys 
            100                 105                 110         


Ala Lys Arg Gly Ile Phe Lys Val Gly Arg Tyr Arg Pro Asp Met Pro 
        115                 120                 125             


Cys Phe Leu Leu Ser Asn Gln Asn Ala Val Lys Ala Glu Pro Lys Lys 
    130                 135                 140                 


Ala Ile Pro Ser Ser Val Arg Ile Thr Arg Ser Lys Ala Lys Asp Gln 
145                 150                 155                 160 


Met Glu Gln Thr Lys Ile Asp Asn Glu Ser Asp Val Arg Ala Ile Arg 
                165                 170                 175     


Pro Gly Pro Arg Gln Thr Ser Glu Lys Lys Val Ser Asp Lys Glu Lys 
            180                 185                 190         


Lys Val Val Gln Pro Val Met Pro Thr Ser Leu Arg Met Thr Arg Ser 
        195                 200                 205             


Ala Thr Gln Ala Ala Lys Gln Val Pro Arg Thr Val Ser Ser Thr Thr 
    210                 215                 220                 


Ala Arg Lys Pro Val Thr Arg Ala Ala Asn Glu Asn Glu Pro Glu Gly 
225                 230                 235                 240 


Lys Val Pro Ser Lys Gly Arg Pro Ala Lys Asn Val Glu Thr Lys Pro 
                245                 250                 255     


Asp Lys Gly Ile Ser Cys Lys Val Asp Ser Glu Glu Asn Thr Leu Asn 
            260                 265                 270         


Ser Gln Thr Asn Ala Thr Ser Gly Met Asn Pro Asp Gly Val Leu Ser 
        275                 280                 285             


Lys Met Glu Asn Leu Pro Glu Ile Asn Thr Ala Lys Ile Lys Gly Lys 
    290                 295                 300                 


Asn Ser Phe Ala Pro Lys Asp Phe Met Phe Gln Pro Leu Asp Gly Leu 
305                 310                 315                 320 


Lys Thr Tyr Gln Val Thr Pro Met Thr Pro Arg Ser Ala Asn Ala Phe 
                325                 330                 335     


Leu Thr Pro Ser Tyr Thr Trp Thr Pro Leu Lys Thr Glu Val Asp Glu 
            340                 345                 350         


Ser Gln Ala Thr Lys Glu Ile Leu Ala Gln Lys Cys Lys Thr Tyr Ser 
        355                 360                 365             


Thr Lys Thr Ile Gln Gln Asp Ser Asn Lys Leu Pro Cys Pro Leu Gly 
    370                 375                 380                 


Pro Leu Thr Val Trp His Glu Glu His Val Leu Asn Lys Asn Glu Ala 
385                 390                 395                 400 


Thr Thr Lys Asn Leu Asn Gly Leu Pro Ile Lys Glu Val Pro Ser Leu 
                405                 410                 415     


Glu Arg Asn Glu Gly Arg Ile Ala Gln Pro His His Gly Val Pro Tyr 
            420                 425                 430         


Phe Arg Asn Ile Leu Gln Ser Glu Thr Glu Lys Leu Thr Ser His Cys 
        435                 440                 445             


Phe Glu Trp Asp Arg Lys Leu Glu Leu Asp Ile Pro Asp Asp Ala Lys 
    450                 455                 460                 


Asp Leu Ile Arg Thr Ala Val Gly Gln Thr Arg Leu Leu Met Lys Glu 
465                 470                 475                 480 


Arg Phe Lys Gln Phe Glu Gly Leu Val Asp Asp Cys Glu Tyr Lys Arg 
                485                 490                 495     


Gly Ile Lys Glu Thr Thr Cys Thr Asp Leu Asp Gly Phe Trp Asp Met 
            500                 505                 510         


Val Ser Phe Gln Ile Glu Asp Val Ile His Lys Phe Asn Asn Leu Ile 
        515                 520                 525             


Lys Leu Glu Glu Ser Gly Trp Gln Val Asn Asn Asn Met Asn His Asn 
    530                 535                 540                 


Met Asn Lys Asn Val Phe Arg Lys Lys Val Val Ser Gly Ile Ala Ser 
545                 550                 555                 560 


Lys Pro Lys Gln Asp Asp Ala Gly Arg Ile Ala Ala Arg Asn Arg Leu 
                565                 570                 575     


Ala Ala Ile Lys Asn Ala Met Arg Glu Arg Ile Arg Gln Glu Glu Cys 
            580                 585                 590         


Ala Glu Thr Ala Val Ser Val Ile Pro Lys Glu Val Asp Lys Ile Val 
        595                 600                 605             


Phe Asp Ala Gly Phe Phe Arg Val Glu Ser Pro Val Lys Leu Phe Ser 
    610                 615                 620                 


Gly Leu Ser Val Ser Ser Glu Gly Pro Ser Gln Arg Leu Gly Thr Pro 
625                 630                 635                 640 


Lys Ser Val Asn Lys Ala Val Ser Gln Ser Arg Asn Glu Met Gly Ile 
                645                 650                 655     


Pro Gln Gln Thr Thr Ser Pro Glu Asn Ala Gly Pro Gln Asn Thr Lys 
            660                 665                 670         


Ser Glu His Val Lys Lys Thr Leu Phe Leu Ser Ile Pro Glu Ser Arg 
        675                 680                 685             


Ser Ser Ile Glu Asp Ala Gln Cys Pro Gly Leu Pro Asp Leu Ile Glu 
    690                 695                 700                 


Glu Asn His Val Val Asn Lys Thr Asp Leu Lys Val Asp Cys Leu Ser 
705                 710                 715                 720 


Ser Glu Arg Met Ser Leu Pro Leu Leu Ala Gly Gly Val Ala Asp Asp 
                725                 730                 735     


Ile Asn Thr Asn Lys Lys Glu Gly Ile Ser Asp Val Val Glu Gly Met 
            740                 745                 750         


Glu Leu Asn Ser Ser Ile Thr Ser Gln Asp Val Leu Met Ser Ser Pro 
        755                 760                 765             


Glu Lys Asn Thr Ala Ser Gln Asn Ser Ile Leu Glu Glu Gly Glu Thr 
    770                 775                 780                 


Lys Ile Ser Gln Ser Glu Leu Phe Asp Asn Lys Ser Leu Thr Thr Glu 
785                 790                 795                 800 


Cys His Leu Leu Asp Ser Val Gly Ser Cys Tyr Val Ala Arg Ala Gly 
                805                 810                 815     


Leu Glu Val Leu Gly Ser Ser Asp Pro Thr Thr Ser Ala Ser Arg Val 
            820                 825                 830         


Ala Gly Thr Thr Ala Arg Ser Lys Leu Gln 
        835                 840         


<210> 6902
<211> 569
<212> PRT
<213> Homo sapiens

<400> 6902
Met Leu Cys Ser Pro Ser Phe Cys Lys Leu Cys Trp Lys Arg Gln Arg 
1               5                   10                  15      


Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp Ala 
            20                  25                  30          


Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro Arg 
        35                  40                  45              


Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly Lys 
    50                  55                  60                  


Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg Gly 
65                  70                  75                  80  


Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala Ile 
                85                  90                  95      


Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly Val 
            100                 105                 110         


Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro Lys 
        115                 120                 125             


Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr Glu 
    130                 135                 140                 


Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr Lys 
145                 150                 155                 160 


Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala Ala 
                165                 170                 175     


Met Ala Arg Arg Lys Leu Leu Pro Gly Arg Ile Gln Leu Trp Gly His 
            180                 185                 190         


Gly Ile Ala Val Asp Trp Ala Glu Pro Glu Val Glu Val Asp Glu Asp 
        195                 200                 205             


Thr Met Ser Ser Val Lys Ile Leu Tyr Val Arg Asn Leu Met Leu Ser 
    210                 215                 220                 


Thr Ser Glu Glu Met Ile Glu Lys Glu Phe Asn Asn Ile Lys Pro Gly 
225                 230                 235                 240 


Ala Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His Phe 
                245                 250                 255     


Ser Asn Arg Glu Asp Ala Val Glu Ala Met Lys Ala Leu Asn Gly Lys 
            260                 265                 270         


Val Leu Asp Gly Ser Pro Ile Glu Val Thr Leu Ala Lys Pro Val Asp 
        275                 280                 285             


Lys Asp Ser Tyr Val Arg Tyr Thr Arg Gly Thr Gly Gly Arg Gly Thr 
    290                 295                 300                 


Met Leu Gln Gly Glu Tyr Thr Tyr Ser Leu Gly Gln Val Tyr Asp Pro 
305                 310                 315                 320 


Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe Tyr Ala Pro Gln Thr Tyr 
                325                 330                 335     


Ala Ala Ile Pro Ser Leu His Phe Pro Ala Thr Lys Gly His Leu Ser 
            340                 345                 350         


Asn Arg Ala Ile Ile Arg Ala Pro Ser Val Arg Gly Ala Ala Gly Val 
        355                 360                 365             


Arg Gly Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu Gly Arg 
    370                 375                 380                 


Gly Tyr Gln Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr Asp Ile 
385                 390                 395                 400 


Leu Pro Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu Lys Pro 
                405                 410                 415     


Gln Gly Ile Lys Leu Ala Pro Gln Ile Leu Glu Glu Ile Cys Gln Lys 
            420                 425                 430         


Asn Asn Trp Gly Gln Pro Val Tyr Gln Leu His Ser Ala Ile Gly Gln 
        435                 440                 445             


Asp Gln Arg Gln Leu Phe Leu Tyr Lys Ile Thr Ile Pro Ala Leu Ala 
    450                 455                 460                 


Ser Gln Asn Pro Ala Ile His Pro Phe Thr Pro Pro Lys Leu Ser Ala 
465                 470                 475                 480 


Phe Val Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu Gln Thr 
                485                 490                 495     


Leu Gly Ile Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr Ala Ala 
            500                 505                 510         


Ala Ala Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala Thr Ala 
        515                 520                 525             


Pro Val Ser Ala Ala Gln Leu Lys Gln Ala Val Thr Leu Gly Gln Asp 
    530                 535                 540                 


Leu Ala Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala Val Thr 
545                 550                 555                 560 


Ala Arg Gly Asp Gly Tyr Gly Thr Phe 
                565                 


<210> 6903
<211> 587
<212> PRT
<213> Homo sapiens

<400> 6903
Met Ser Thr Ala Ile Pro Gly Leu Lys Lys Gly Asn Asn Ala Leu Gln 
1               5                   10                  15      


Ser Ile Ile Leu Gln Thr Leu Leu Glu Lys Glu Asn Gly Gln Arg Lys 
            20                  25                  30          


Tyr Gly Gly Pro Pro Pro Gly Trp Asp Ala Ala Pro Pro Glu Arg Gly 
        35                  40                  45              


Cys Glu Ile Phe Ile Gly Lys Leu Pro Arg Asp Leu Phe Glu Asp Glu 
    50                  55                  60                  


Leu Ile Pro Leu Cys Glu Lys Ile Gly Lys Ile Tyr Glu Met Arg Met 
65                  70                  75                  80  


Met Met Asp Phe Asn Gly Asn Asn Arg Gly Tyr Ala Phe Val Thr Phe 
                85                  90                  95      


Ser Asn Lys Val Glu Ala Lys Asn Ala Ile Lys Gln Leu Asn Asn Tyr 
            100                 105                 110         


Glu Ile Arg Asn Gly Arg Leu Leu Gly Val Cys Ala Ser Val Asp Asn 
        115                 120                 125             


Cys Arg Leu Phe Val Gly Gly Ile Pro Lys Thr Lys Lys Arg Glu Glu 
    130                 135                 140                 


Ile Leu Ser Glu Met Lys Lys Val Thr Glu Gly Val Val Asp Val Ile 
145                 150                 155                 160 


Val Tyr Pro Ser Ala Ala Asp Lys Thr Lys Asn Arg Gly Phe Ala Phe 
                165                 170                 175     


Val Glu Tyr Glu Ser His Arg Ala Ala Ala Met Ala Arg Arg Lys Leu 
            180                 185                 190         


Leu Pro Gly Arg Ile Gln Leu Trp Gly His Gly Ile Ala Val Asp Trp 
        195                 200                 205             


Ala Glu Pro Glu Val Glu Val Asp Glu Asp Thr Met Ser Ser Val Lys 
    210                 215                 220                 


Ile Leu Tyr Val Arg Asn Leu Met Leu Ser Thr Ser Glu Glu Met Ile 
225                 230                 235                 240 


Glu Lys Glu Phe Asn Asn Ile Lys Pro Gly Ala Val Glu Arg Val Lys 
                245                 250                 255     


Lys Ile Arg Asp Tyr Ala Phe Val His Phe Ser Asn Arg Glu Asp Ala 
            260                 265                 270         


Val Glu Ala Met Lys Ala Leu Asn Gly Lys Val Leu Asp Gly Ser Pro 
        275                 280                 285             


Ile Glu Val Thr Leu Ala Lys Pro Val Asp Lys Asp Ser Tyr Val Arg 
    290                 295                 300                 


Tyr Thr Arg Gly Thr Gly Gly Arg Gly Thr Met Leu Gln Gly Glu Tyr 
305                 310                 315                 320 


Thr Tyr Ser Leu Gly Gln Val Tyr Asp Pro Thr Thr Thr Tyr Leu Gly 
                325                 330                 335     


Ala Pro Val Phe Tyr Ala Pro Gln Thr Tyr Ala Ala Ile Pro Ser Leu 
            340                 345                 350         


His Phe Pro Ala Thr Lys Gly His Leu Ser Asn Arg Ala Ile Ile Arg 
        355                 360                 365             


Ala Pro Ser Val Arg Glu Ile Tyr Met Asn Val Pro Val Gly Ala Ala 
    370                 375                 380                 


Gly Val Arg Gly Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu 
385                 390                 395                 400 


Gly Arg Gly Tyr Gln Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr 
                405                 410                 415     


Asp Ile Leu Pro Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu 
            420                 425                 430         


Lys Pro Gln Gly Ile Lys Leu Ala Pro Gln Ile Leu Glu Glu Ile Cys 
        435                 440                 445             


Gln Lys Asn Asn Trp Gly Gln Pro Val Tyr Gln Leu His Ser Ala Ile 
    450                 455                 460                 


Gly Gln Asp Gln Arg Gln Leu Phe Leu Tyr Lys Ile Thr Ile Pro Ala 
465                 470                 475                 480 


Leu Ala Ser Gln Asn Pro Ala Ile His Pro Phe Thr Pro Pro Lys Leu 
                485                 490                 495     


Ser Ala Phe Val Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu 
            500                 505                 510         


Gln Thr Leu Gly Ile Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr 
        515                 520                 525             


Ala Ala Ala Ala Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala 
    530                 535                 540                 


Thr Ala Pro Val Ser Ala Ala Gln Leu Lys Gln Ala Val Thr Leu Gly 
545                 550                 555                 560 


Gln Asp Leu Ala Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala 
                565                 570                 575     


Val Thr Ala Arg Gly Asp Gly Tyr Gly Thr Phe 
            580                 585         


<210> 6904
<211> 539
<212> PRT
<213> Homo sapiens

<400> 6904
Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys 
1               5                   10                  15      


Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val 
            20                  25                  30          


Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp 
        35                  40                  45              


Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro 
    50                  55                  60                  


Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly 
65                  70                  75                  80  


Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg 
                85                  90                  95      


Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala 
            100                 105                 110         


Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly 
        115                 120                 125             


Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro 
    130                 135                 140                 


Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr 
145                 150                 155                 160 


Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr 
                165                 170                 175     


Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Arg Arg Lys Leu Leu Pro Gly Ala Val Glu Arg Val Lys 
        195                 200                 205             


Lys Ile Arg Asp Tyr Ala Phe Val His Phe Ser Asn Arg Glu Asp Ala 
    210                 215                 220                 


Val Glu Ala Met Lys Ala Leu Asn Gly Lys Val Leu Asp Gly Ser Pro 
225                 230                 235                 240 


Ile Glu Val Thr Leu Ala Lys Pro Val Asp Lys Asp Ser Tyr Val Arg 
                245                 250                 255     


Tyr Thr Arg Gly Thr Gly Gly Arg Gly Thr Met Leu Gln Gly Glu Tyr 
            260                 265                 270         


Thr Tyr Ser Leu Gly Gln Val Tyr Asp Pro Thr Thr Thr Tyr Leu Gly 
        275                 280                 285             


Ala Pro Val Phe Tyr Ala Pro Gln Thr Tyr Ala Ala Ile Pro Ser Leu 
    290                 295                 300                 


His Phe Pro Ala Thr Lys Gly His Leu Ser Asn Arg Ala Ile Ile Arg 
305                 310                 315                 320 


Ala Pro Ser Val Arg Glu Ile Tyr Met Asn Val Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Val Arg Gly Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu 
            340                 345                 350         


Gly Arg Gly Tyr Gln Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr 
        355                 360                 365             


Asp Ile Leu Pro Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu 
    370                 375                 380                 


Lys Pro Gln Gly Ile Lys Leu Ala Pro Gln Ile Leu Glu Glu Ile Cys 
385                 390                 395                 400 


Gln Lys Asn Asn Trp Gly Gln Pro Val Tyr Gln Leu His Ser Ala Ile 
                405                 410                 415     


Gly Gln Asp Gln Arg Gln Leu Phe Leu Tyr Lys Ile Thr Ile Pro Ala 
            420                 425                 430         


Leu Ala Ser Gln Asn Pro Ala Ile His Pro Phe Thr Pro Pro Lys Leu 
        435                 440                 445             


Ser Ala Phe Val Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu 
    450                 455                 460                 


Gln Thr Leu Gly Ile Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala 
                485                 490                 495     


Thr Ala Pro Val Ser Ala Ala Gln Leu Lys Gln Ala Val Thr Leu Gly 
            500                 505                 510         


Gln Asp Leu Ala Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala 
        515                 520                 525             


Val Thr Ala Arg Gly Asp Gly Tyr Gly Thr Phe 
    530                 535                 


<210> 6905
<211> 347
<212> PRT
<213> Homo sapiens

<400> 6905
Phe Ser Leu Phe Pro Ala Val Asp Asn Glu Glu Ala Ala Leu Leu His 
1               5                   10                  15      


Glu Glu Ala Thr Met Thr Ile Glu Glu Leu Leu Thr Arg Tyr Gly Gln 
            20                  25                  30          


Asn Cys His Lys Gly Pro Pro His Ser Lys Ser Gly Ala Ser Asp Lys 
        35                  40                  45              


Leu Pro Arg Val Ala Lys Ser Lys Phe Phe Glu Asp Ser Glu Asp Glu 
    50                  55                  60                  


Ser Asp Glu Ala Glu Glu Glu Glu Glu Asp Ser Glu Glu Cys Ser Glu 
65                  70                  75                  80  


Glu Glu Asp Gly Tyr Ser Ser Glu Glu Ala Glu Asn Glu Glu Asp Glu 
                85                  90                  95      


Asp Asp Thr Glu Glu Ala Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Met Met Val Pro Gly Met Glu Gly Lys Glu Glu Pro Gly Ser Asp Ser 
        115                 120                 125             


Gly Thr Thr Ala Val Val Ala Leu Ile Arg Gly Lys Gln Leu Ile Val 
    130                 135                 140                 


Ala Asn Ala Gly Asp Ser Arg Cys Val Val Ser Glu Ala Gly Lys Ala 
145                 150                 155                 160 


Leu Asp Met Ser Tyr Asp His Lys Pro Glu Asp Glu Val Glu Leu Ala 
                165                 170                 175     


Arg Ile Lys Asn Ala Gly Gly Lys Val Thr Met Asp Gly Arg Val Asn 
            180                 185                 190         


Gly Gly Leu Asn Leu Ser Arg Ala Ile Gly Asp His Phe Tyr Lys Arg 
        195                 200                 205             


Asn Lys Asn Leu Pro Pro Glu Glu Gln Met Ile Ser Ala Leu Pro Asp 
    210                 215                 220                 


Ile Lys Val Leu Thr Leu Thr Asp Asp His Glu Phe Met Val Ile Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Trp Asn Val Met Ser Ser Gln Glu Val Val Asp Phe 
                245                 250                 255     


Ile Gln Ser Lys Ile Ser Gln Arg Asp Glu Asn Gly Glu Leu Arg Leu 
            260                 265                 270         


Leu Ser Ser Ile Val Glu Glu Leu Leu Asp Gln Cys Leu Ala Pro Asp 
        275                 280                 285             


Thr Ser Gly Asp Gly Thr Gly Cys Asp Asn Met Thr Cys Ile Ile Ile 
    290                 295                 300                 


Cys Phe Lys Pro Arg Asn Thr Ala Glu Leu Gln Pro Glu Ser Gly Lys 
305                 310                 315                 320 


Arg Lys Leu Glu Glu Val Leu Ser Thr Glu Gly Ala Glu Glu Asn Gly 
                325                 330                 335     


Asn Ser Asp Lys Lys Lys Lys Ala Lys Arg Asp 
            340                 345         


<210> 6906
<211> 405
<212> PRT
<213> Homo sapiens

<400> 6906
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Met Val Pro Gly Lys Glu Gly Gly 
            260                 265                 270         


Val Pro Leu Ala Pro Asn Gln Pro Val His Gly Thr Gln Ala Asp Gln 
        275                 280                 285             


Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg Thr His Cys Ala Ala 
    290                 295                 300                 


Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val Ser Asn Ser Ser Glu 
305                 310                 315                 320 


Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr Ile Phe Val Arg Lys 
                325                 330                 335     


Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln Val Thr Leu Thr Ser 
            340                 345                 350         


Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys Asn Leu Glu Leu Glu 
        355                 360                 365             


Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser Pro Glu Thr Glu Ser 
    370                 375                 380                 


Pro Leu Gln Gly Ser Leu Pro Cys Ser Trp Pro Leu Pro Cys Leu Leu 
385                 390                 395                 400 


Ser Pro Ser Thr Val 
                405 


<210> 6907
<211> 674
<212> PRT
<213> Homo sapiens

<400> 6907
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met 
            100                 105                 110         


Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser 
        115                 120                 125             


Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr 
    130                 135                 140                 


Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser 
145                 150                 155                 160 


Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe 
                165                 170                 175     


Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met 
            180                 185                 190         


Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly 
        195                 200                 205             


Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val 
    210                 215                 220                 


Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val 
225                 230                 235                 240 


Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln 
                245                 250                 255     


Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro 
            260                 265                 270         


Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu 
        275                 280                 285             


Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val 
    290                 295                 300                 


Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser 
305                 310                 315                 320 


Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile 
                325                 330                 335     


Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln 
            340                 345                 350         


Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro 
        355                 360                 365             


Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile 
    370                 375                 380                 


Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp 
385                 390                 395                 400 


Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile 
                405                 410                 415     


Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly 
            420                 425                 430         


Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser 
    450                 455                 460                 


Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys 
465                 470                 475                 480 


Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val 
                485                 490                 495     


Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly 
            500                 505                 510         


Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu 
        515                 520                 525             


Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala 
    530                 535                 540                 


Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val 
545                 550                 555                 560 


Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile 
                565                 570                 575     


Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu 
            580                 585                 590         


Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met 
        595                 600                 605             


Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln 
    610                 615                 620                 


Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala 
625                 630                 635                 640 


Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser 
                645                 650                 655     


Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys 
            660                 665                 670         


Gly Lys 
        


<210> 6908
<211> 879
<212> PRT
<213> Homo sapiens

<400> 6908
Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly 
1               5                   10                  15      


Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro 
            20                  25                  30          


Ala Phe Gly Gly Gly Val Cys Cys Phe Glu His Leu Pro Gly Gly Asp 
        35                  40                  45              


Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly 
    50                  55                  60                  


Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu 
65                  70                  75                  80  


Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser 
                85                  90                  95      


Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val Pro Thr 
        115                 120                 125             


Asn Ser Gly Gly Gly Gly Ala Thr Gly Gly Ser Pro Gly Glu Arg Lys 
    130                 135                 140                 


Arg Thr Arg Leu Gly Gly Pro Ala Ala Arg His Arg Tyr Glu Val Val 
145                 150                 155                 160 


Thr Glu Leu Gly Pro Glu Glu Val Arg Trp Phe Tyr Lys Glu Asp Lys 
                165                 170                 175     


Lys Thr Trp Lys Pro Phe Ile Gly Tyr Asp Ser Leu Arg Ile Glu Leu 
            180                 185                 190         


Ala Phe Arg Thr Leu Leu Gln Thr Thr Gly Ala Arg Pro Gln Gly Gly 
        195                 200                 205             


Asp Arg Asp Gly Asp His Val Cys Ser Pro Thr Gly Pro Ala Ser Ser 
    210                 215                 220                 


Ser Gly Glu Asp Asp Asp Glu Asp Arg Ala Cys Gly Phe Cys Gln Ser 
225                 230                 235                 240 


Thr Thr Gly His Glu Pro Glu Met Val Glu Leu Val Asn Ile Glu Pro 
                245                 250                 255     


Val Cys Val Arg Gly Gly Leu Tyr Glu Val Asp Val Thr Gln Gly Glu 
            260                 265                 270         


Cys Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val Met Arg 
        275                 280                 285             


Gly Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu Glu Glu 
    290                 295                 300                 


Ser Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly Gln Gln 
305                 310                 315                 320 


Met Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp Gly Lys 
                325                 330                 335     


Asp Gly Ser Gly Ile Asn Tyr Ser Ala Val His Ser Phe Lys Leu Ser 
            340                 345                 350         


Arg Asn His Val Asp Trp His Ser Val Asp Glu Val Tyr Leu Tyr Ser 
        355                 360                 365             


Asp Ala Thr Thr Ser Lys Ile Ala Arg Thr Val Thr Gln Lys Leu Gly 
    370                 375                 380                 


Phe Ser Lys Ala Ser Ser Ser Gly Thr Arg Leu His Arg Gly Tyr Val 
385                 390                 395                 400 


Glu Glu Ala Thr Leu Glu Asp Lys Pro Ser Gln Thr Thr His Ile Val 
                405                 410                 415     


Phe Val Val His Gly Ile Gly Gln Lys Met Asp Gln Gly Arg Ile Ile 
            420                 425                 430         


Lys Asn Thr Ala Met Met Arg Glu Ala Ala Arg Lys Ile Glu Glu Arg 
        435                 440                 445             


His Phe Ser Asn His Ala Thr His Val Glu Phe Leu Pro Val Glu Trp 
    450                 455                 460                 


Arg Ser Lys Leu Thr Leu Asp Gly Asp Thr Val Asp Ser Ile Thr Pro 
465                 470                 475                 480 


Asp Lys Val Arg Gly Leu Arg Asp Met Leu Asn Ser Ser Ala Met Asp 
                485                 490                 495     


Ile Met Tyr Tyr Thr Ser Pro Leu Tyr Arg Asp Glu Leu Val Lys Gly 
            500                 505                 510         


Leu Gln Gln Glu Leu Asn Arg Leu Tyr Ser Leu Phe Cys Ser Arg Asn 
        515                 520                 525             


Pro Asp Phe Glu Glu Lys Gly Gly Lys Val Ser Ile Val Ser His Ser 
    530                 535                 540                 


Leu Gly Cys Val Ile Thr Tyr Asp Ile Met Thr Gly Trp Asn Pro Val 
545                 550                 555                 560 


Arg Leu Tyr Glu Gln Leu Leu Gln Lys Glu Glu Glu Leu Pro Asp Glu 
                565                 570                 575     


Arg Trp Met Ser Tyr Glu Glu Arg His Leu Leu Asp Glu Leu Tyr Ile 
            580                 585                 590         


Thr Lys Arg Arg Leu Lys Glu Ile Glu Glu Arg Leu His Gly Leu Lys 
        595                 600                 605             


Ala Ser Ser Met Thr Gln Thr Pro Ala Leu Lys Phe Lys Val Glu Asn 
    610                 615                 620                 


Phe Phe Cys Met Gly Ser Pro Leu Ala Val Phe Leu Ala Leu Arg Gly 
625                 630                 635                 640 


Ile Arg Pro Gly Asn Thr Gly Ser Gln Asp His Ile Leu Pro Arg Glu 
                645                 650                 655     


Ile Cys Asn Arg Leu Leu Asn Ile Phe His Pro Thr Asp Pro Val Ala 
            660                 665                 670         


Tyr Arg Leu Glu Pro Leu Ile Leu Lys His Tyr Ser Asn Ile Ser Pro 
        675                 680                 685             


Val Gln Ile His Trp Tyr Asn Thr Ser Asn Pro Leu Pro Tyr Glu His 
    690                 695                 700                 


Met Lys Pro Ser Phe Leu Asn Pro Ala Lys Glu Pro Thr Ser Val Ser 
705                 710                 715                 720 


Glu Asn Glu Gly Ile Ser Thr Ile Pro Ser Pro Val Thr Ser Pro Val 
                725                 730                 735     


Leu Ser Arg Arg His Tyr Gly Glu Ser Ile Thr Asn Ile Gly Lys Ala 
            740                 745                 750         


Ser Ile Leu Gly Ala Ala Ser Ile Gly Lys Gly Leu Gly Gly Met Leu 
        755                 760                 765             


Phe Ser Arg Phe Gly Arg Ser Ser Thr Thr Gln Ser Ser Glu Thr Ser 
    770                 775                 780                 


Lys Asp Ser Met Glu Asp Glu Lys Lys Pro Val Ala Ser Pro Ser Ala 
785                 790                 795                 800 


Thr Thr Val Gly Thr Gln Thr Leu Pro His Ser Ser Ser Gly Phe Leu 
                805                 810                 815     


Asp Ser Ala Leu Glu Leu Asp His Arg Ile Asp Phe Glu Leu Arg Glu 
            820                 825                 830         


Gly Leu Val Glu Ser Arg Tyr Trp Ser Ala Val Thr Ser His Thr Ala 
        835                 840                 845             


Tyr Trp Ser Ser Leu Asp Val Ala Leu Phe Leu Leu Thr Phe Met Tyr 
    850                 855                 860                 


Lys His Glu His Asp Asp Asp Ala Lys Pro Asn Leu Asp Pro Ile 
865                 870                 875                 


<210> 6909
<211> 771
<212> PRT
<213> Homo sapiens

<400> 6909
Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly 
1               5                   10                  15      


Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro 
            20                  25                  30          


Ala Phe Gly Gly Gly Val Cys Cys Phe Glu His Leu Pro Gly Gly Asp 
        35                  40                  45              


Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly 
    50                  55                  60                  


Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu 
65                  70                  75                  80  


Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser 
                85                  90                  95      


Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val Pro Thr 
        115                 120                 125             


Asn Ser Gly Gly Gly Leu Tyr Glu Val Asp Val Thr Gln Gly Glu Cys 
    130                 135                 140                 


Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val Met Arg Gly 
145                 150                 155                 160 


Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu Glu Glu Ser 
                165                 170                 175     


Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly Gln Gln Met 
            180                 185                 190         


Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp Gly Lys Asp 
        195                 200                 205             


Ala Val His Ser Phe Lys Leu Ser Arg Asn His Val Asp Trp His Ser 
    210                 215                 220                 


Val Asp Glu Val Tyr Leu Tyr Ser Asp Ala Thr Thr Ser Lys Ile Ala 
225                 230                 235                 240 


Arg Thr Val Thr Gln Lys Leu Gly Phe Ser Lys Ala Ser Ser Ser Gly 
                245                 250                 255     


Thr Arg Leu His Arg Gly Tyr Val Glu Glu Ala Thr Leu Glu Asp Lys 
            260                 265                 270         


Pro Ser Gln Thr Thr His Ile Val Phe Val Val His Gly Ile Gly Gln 
        275                 280                 285             


Lys Met Asp Gln Gly Arg Ile Ile Lys Asn Thr Ala Met Met Arg Glu 
    290                 295                 300                 


Ala Ala Arg Lys Ile Glu Glu Arg His Phe Ser Asn His Ala Thr His 
305                 310                 315                 320 


Val Glu Phe Leu Pro Val Glu Trp Arg Ser Lys Leu Thr Leu Asp Gly 
                325                 330                 335     


Asp Thr Val Asp Ser Ile Thr Pro Asp Lys Val Arg Gly Leu Arg Asp 
            340                 345                 350         


Met Leu Asn Ser Ser Ala Met Asp Ile Met Tyr Tyr Thr Ser Pro Leu 
        355                 360                 365             


Tyr Arg Asp Glu Leu Val Lys Gly Leu Gln Gln Glu Leu Asn Arg Leu 
    370                 375                 380                 


Tyr Ser Leu Phe Cys Ser Arg Asn Pro Asp Phe Glu Glu Lys Gly Gly 
385                 390                 395                 400 


Lys Val Ser Ile Val Ser His Ser Leu Gly Cys Val Ile Thr Tyr Asp 
                405                 410                 415     


Ile Met Thr Gly Trp Asn Pro Val Arg Leu Tyr Glu Gln Leu Leu Gln 
            420                 425                 430         


Lys Glu Glu Glu Leu Pro Asp Glu Arg Trp Met Ser Tyr Glu Glu Arg 
        435                 440                 445             


His Leu Leu Asp Glu Leu Tyr Ile Thr Lys Arg Arg Leu Lys Glu Ile 
    450                 455                 460                 


Glu Glu Arg Leu His Gly Leu Lys Ala Ser Ser Met Thr Gln Thr Pro 
465                 470                 475                 480 


Ala Leu Lys Phe Lys Val Glu Asn Phe Phe Cys Met Gly Ser Pro Leu 
                485                 490                 495     


Ala Val Phe Leu Ala Leu Arg Gly Ile Arg Pro Gly Asn Thr Gly Ser 
            500                 505                 510         


Gln Asp His Ile Leu Pro Arg Glu Ile Cys Asn Arg Leu Leu Asn Ile 
        515                 520                 525             


Phe His Pro Thr Asp Pro Val Ala Tyr Arg Leu Glu Pro Leu Ile Leu 
    530                 535                 540                 


Lys His Tyr Ser Asn Ile Ser Pro Val Gln Ile His Trp Tyr Asn Thr 
545                 550                 555                 560 


Ser Asn Pro Leu Pro Tyr Glu His Met Lys Pro Ser Phe Leu Asn Pro 
                565                 570                 575     


Ala Lys Glu Pro Thr Ser Val Ser Glu Asn Glu Gly Ile Ser Thr Ile 
            580                 585                 590         


Pro Ser Pro Val Thr Ser Pro Val Leu Ser Arg Arg His Tyr Gly Glu 
        595                 600                 605             


Ser Ile Thr Asn Ile Gly Lys Ala Ser Ile Leu Gly Ala Ala Ser Ile 
    610                 615                 620                 


Gly Lys Gly Leu Gly Gly Met Leu Phe Ser Arg Phe Gly Arg Ser Ser 
625                 630                 635                 640 


Thr Thr Gln Ser Ser Glu Thr Ser Lys Asp Ser Met Glu Asp Glu Lys 
                645                 650                 655     


Lys Pro Val Ala Ser Pro Ser Ala Thr Thr Val Gly Thr Gln Thr Leu 
            660                 665                 670         


Pro His Ser Ser Ser Gly Phe Leu Asp Ser Ala Tyr Phe Arg Leu Gln 
        675                 680                 685             


Glu Ser Phe Phe Asn Leu Pro Gln Leu Leu Phe Pro Glu Asn Val Met 
    690                 695                 700                 


Gln Asn Lys Asp Asn Ala Leu Val Glu Leu Asp His Arg Ile Asp Phe 
705                 710                 715                 720 


Glu Leu Arg Glu Gly Leu Val Glu Ser Arg Tyr Trp Ser Ala Val Thr 
                725                 730                 735     


Ser His Thr Ala Tyr Trp Ser Ser Leu Asp Val Ala Leu Phe Leu Leu 
            740                 745                 750         


Thr Phe Met Tyr Lys His Glu His Asp Asp Asp Ala Lys Pro Asn Leu 
        755                 760                 765             


Asp Pro Ile 
    770     


<210> 6910
<211> 392
<212> PRT
<213> Homo sapiens

<400> 6910
Met Gly Thr Thr Cys Leu His Leu Gly Thr Leu Glu Gln Ser Leu Val 
1               5                   10                  15      


Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn 
            20                  25                  30          


Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser 
        35                  40                  45              


Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp 
    50                  55                  60                  


Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu 
65                  70                  75                  80  


Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu 
                85                  90                  95      


Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln 
            100                 105                 110         


Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala 
        115                 120                 125             


Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro 
    130                 135                 140                 


Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg 
145                 150                 155                 160 


Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys 
                165                 170                 175     


Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly 
            180                 185                 190         


Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile 
        195                 200                 205             


Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala 
    210                 215                 220                 


Met Ile Thr Arg Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr 
225                 230                 235                 240 


Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val 
                245                 250                 255     


Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe 
            260                 265                 270         


Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu 
        275                 280                 285             


Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser 
    290                 295                 300                 


Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro 
305                 310                 315                 320 


Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu 
                325                 330                 335     


Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn 
            340                 345                 350         


Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val 
        355                 360                 365             


Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val 
    370                 375                 380                 


Leu Arg Lys Leu Leu Thr Leu Asp 
385                 390         


<210> 6911
<211> 206
<212> PRT
<213> Homo sapiens

<400> 6911
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu 
                165                 170                 175     


Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr 
            180                 185                 190         


Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
        195                 200                 205     


<210> 6912
<211> 145
<212> PRT
<213> Homo sapiens

<400> 6912
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe 
        115                 120                 125             


Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys 
    130                 135                 140                 


Ala 
145 


<210> 6913
<211> 339
<212> PRT
<213> Homo sapiens

<400> 6913
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr Ile 
        115                 120                 125             


Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe Tyr 
    130                 135                 140                 


Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp Gln 
145                 150                 155                 160 


Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg Glu 
                165                 170                 175     


Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn Tyr 
        195                 200                 205             


Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu Lys 
    210                 215                 220                 


Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys Trp 
225                 230                 235                 240 


Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile 
                245                 250                 255     


Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His Cys 
            260                 265                 270         


Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val Val 
        275                 280                 285             


Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile Val 
    290                 295                 300                 


Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln 
305                 310                 315                 320 


Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu 
                325                 330                 335     


Thr Leu Asp 
            


<210> 6914
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6914
Met Gln Phe Gly Glu Leu Leu Ala Ala Val Arg Lys Ala Gln Ala Asn 
1               5                   10                  15      


Val Met Leu Phe Leu Glu Glu Lys Glu Gln Ala Ala Leu Ser Gln Ala 
            20                  25                  30          


Asn Gly Ile Lys Ala His Leu Glu Tyr Arg Ser Ala Glu Met Glu Lys 
        35                  40                  45              


Ser Lys Gln Glu Leu Glu Thr Met Ala Ala Ile Ser Asn Thr Val Gln 
    50                  55                  60                  


Phe Leu Glu Glu Tyr Cys Lys Phe Lys Asn Thr Glu Asp Ile Thr Phe 
65                  70                  75                  80  


Pro Ser Val Tyr Ile Gly Leu Lys Asp Lys Leu Ser Gly Ile Arg Lys 
                85                  90                  95      


Val Ile Thr Glu Ser Thr Val His Leu Ile Gln Leu Leu Glu Asn Tyr 
            100                 105                 110         


Lys Lys Lys Leu Gln Glu Phe Ser Lys Glu Glu Glu Tyr Asp Ile Arg 
        115                 120                 125             


Thr Gln Val Ser Ala Ile Val Gln Arg Lys Tyr Trp Thr Ser Lys Pro 
    130                 135                 140                 


Glu Pro Ser Thr Arg Glu Gln Phe Leu Gln Tyr Val His Asp Ile Thr 
145                 150                 155                 160 


Phe Asp Pro Asp Thr Ala His Lys Tyr Leu Arg Leu Gln Glu Glu Asn 
                165                 170                 175     


Arg Lys Val Thr Asn Thr Thr Pro Trp Glu His Pro Tyr Pro Asp Leu 
            180                 185                 190         


Pro Ser Arg Phe Leu His Trp Arg Gln Val Leu Ser Gln Gln Ser Leu 
        195                 200                 205             


Tyr Leu His Arg Tyr Tyr Phe Glu Val Glu Ile Phe Gly Ala Gly Thr 
    210                 215                 220                 


Tyr Val Gly Leu Thr Cys Lys Gly Ile Asp Gln Lys Gly Glu Glu Arg 
225                 230                 235                 240 


Ser Ser Cys Ile Ser Gly Asn Asn Phe Ser Trp Ser Leu Gln Trp Asn 
                245                 250                 255     


Gly Lys Glu Phe Thr Ala Trp Tyr Ser Asp Met Glu Thr Pro Leu Lys 
            260                 265                 270         


Ala Gly Pro Phe Trp Arg Leu Gly Val Tyr Ile Asp Phe Pro Gly Gly 
        275                 280                 285             


Ile Leu Ser Phe Tyr Gly Val Glu Tyr Asp Ser Met Thr Leu Val His 
    290                 295                 300                 


Lys Phe Ala Cys Lys Phe Ser Glu Pro Val Tyr Ala Ala Phe Trp Leu 
305                 310                 315                 320 


Ser Lys Lys Glu Asn Ala Ile Arg Ile Val Asp Leu Gly Glu Glu Pro 
                325                 330                 335     


Glu Lys Pro Ala Pro Ser Leu Val Gly Thr Ala Pro 
            340                 345             


<210> 6915
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6915
Met Gln Phe Gly Glu Leu Leu Ala Ala Val Arg Lys Ala Gln Ala Asn 
1               5                   10                  15      


Val Met Leu Phe Leu Glu Glu Lys Glu Gln Ala Ala Leu Ser Gln Ala 
            20                  25                  30          


Asn Gly Ile Lys Ala His Leu Glu Tyr Arg Ser Ala Glu Met Glu Lys 
        35                  40                  45              


Ser Lys Gln Glu Leu Glu Thr Met Ala Ala Ile Ser Asn Thr Val Gln 
    50                  55                  60                  


Phe Leu Glu Glu Tyr Cys Lys Phe Lys Asn Thr Glu Asp Ile Thr Phe 
65                  70                  75                  80  


Pro Ser Val Tyr Ile Gly Leu Lys Asp Lys Leu Ser Gly Ile Arg Lys 
                85                  90                  95      


Val Ile Thr Glu Ser Thr Val His Leu Ile Gln Leu Leu Glu Asn Tyr 
            100                 105                 110         


Lys Lys Lys Leu Gln Glu Phe Ser Lys Glu Glu Glu Tyr Asp Ile Arg 
        115                 120                 125             


Thr Gln Val Ser Ala Ile Val Gln Arg Lys Tyr Trp Thr Ser Lys Pro 
    130                 135                 140                 


Glu Pro Ser Thr Arg Glu Gln Phe Leu Gln Tyr Val His Asp Ile Thr 
145                 150                 155                 160 


Phe Asp Pro Asp Thr Ala His Lys Tyr Leu Arg Leu Gln Glu Glu Asn 
                165                 170                 175     


Arg Lys Val Thr Asn Thr Thr Pro Trp Glu His Pro Tyr Pro Asp Leu 
            180                 185                 190         


Pro Ser Arg Phe Leu His Trp Arg Gln Val Leu Ser Gln Gln Ser Leu 
        195                 200                 205             


Tyr Leu His Arg Tyr Tyr Phe Glu Val Glu Ile Phe Gly Ala Gly Thr 
    210                 215                 220                 


Tyr Val Gly Leu Thr Cys Lys Gly Ile Asp Gln Lys Gly Glu Glu Arg 
225                 230                 235                 240 


Ser Ser Cys Ile Ser Gly Asn Asn Phe Ser Trp Ser Leu Gln Trp Asn 
                245                 250                 255     


Gly Lys Glu Phe Thr Ala Trp Tyr Ser Asp Met Glu Thr Pro Leu Lys 
            260                 265                 270         


Ala Gly Pro Phe Trp Arg Leu Gly Val Tyr Ile Asp Phe Pro Gly Gly 
        275                 280                 285             


Ile Leu Ser Phe Tyr Gly Val Glu Tyr Asp Ser Met Thr Leu Val His 
    290                 295                 300                 


Lys Phe Ala Cys Lys Phe Ser Glu Pro Val Tyr Ala Ala Phe Trp Leu 
305                 310                 315                 320 


Ser Lys Lys Glu Asn Ala Ile Arg Ile Val Asp Leu Gly Glu Glu Pro 
                325                 330                 335     


Glu Lys Pro Ala Pro Ser Leu Val Gly Thr Ala Pro 
            340                 345             


<210> 6916
<211> 228
<212> PRT
<213> Homo sapiens

<400> 6916
Met Ile Asp Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr 
1               5                   10                  15      


Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe 
            20                  25                  30          


Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp 
        35                  40                  45              


Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg 
    50                  55                  60                  


Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser 
65                  70                  75                  80  


Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn 
                85                  90                  95      


Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu 
            100                 105                 110         


Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys 
        115                 120                 125             


Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr 
    130                 135                 140                 


Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His 
145                 150                 155                 160 


Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val 
                165                 170                 175     


Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile 
            180                 185                 190         


Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu 
        195                 200                 205             


Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu 
    210                 215                 220                 


Leu Thr Leu Asp 
225             


<210> 6917
<211> 482
<212> PRT
<213> Homo sapiens

<400> 6917
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
    130                 135                 140                 


Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
145                 150                 155                 160 


Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                165                 170                 175     


Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
            180                 185                 190         


Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
        195                 200                 205             


Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
    210                 215                 220                 


Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
225                 230                 235                 240 


Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                245                 250                 255     


Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Pro His Val Lys Ala Pro 
            260                 265                 270         


Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
        275                 280                 285             


Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
    290                 295                 300                 


Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
305                 310                 315                 320 


Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                325                 330                 335     


Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
            340                 345                 350         


Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
        355                 360                 365             


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
    370                 375                 380                 


Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
385                 390                 395                 400 


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                405                 410                 415     


Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
            420                 425                 430         


Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
        435                 440                 445             


Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
    450                 455                 460                 


Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
465                 470                 475                 480 


Arg Arg 
        


<210> 6918
<211> 339
<212> PRT
<213> Homo sapiens

<400> 6918
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr Ile 
        115                 120                 125             


Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe Tyr 
    130                 135                 140                 


Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp Gln 
145                 150                 155                 160 


Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg Glu 
                165                 170                 175     


Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn Tyr 
        195                 200                 205             


Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu Lys 
    210                 215                 220                 


Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys Trp 
225                 230                 235                 240 


Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile 
                245                 250                 255     


Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His Cys 
            260                 265                 270         


Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val Val 
        275                 280                 285             


Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile Val 
    290                 295                 300                 


Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln 
305                 310                 315                 320 


Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu 
                325                 330                 335     


Thr Leu Asp 
            


<210> 6919
<211> 206
<212> PRT
<213> Homo sapiens

<400> 6919
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu 
                165                 170                 175     


Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr 
            180                 185                 190         


Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
        195                 200                 205     


<210> 6920
<211> 145
<212> PRT
<213> Homo sapiens

<400> 6920
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe 
        115                 120                 125             


Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys 
    130                 135                 140                 


Ala 
145 


<210> 6921
<211> 228
<212> PRT
<213> Homo sapiens

<400> 6921
Met Ile Asp Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr 
1               5                   10                  15      


Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe 
            20                  25                  30          


Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp 
        35                  40                  45              


Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg 
    50                  55                  60                  


Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser 
65                  70                  75                  80  


Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn 
                85                  90                  95      


Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu 
            100                 105                 110         


Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys 
        115                 120                 125             


Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr 
    130                 135                 140                 


Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His 
145                 150                 155                 160 


Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val 
                165                 170                 175     


Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile 
            180                 185                 190         


Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu 
        195                 200                 205             


Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu 
    210                 215                 220                 


Leu Thr Leu Asp 
225             


<210> 6922
<211> 933
<212> PRT
<213> Homo sapiens

<400> 6922
Met Phe Trp Lys Phe Asp Leu Asn Thr Thr Ser His Val Asp Lys Leu 
1               5                   10                  15      


Leu Asp Lys Glu His Val Thr Leu Gln Glu Leu Met Asp Glu Asp Asp 
            20                  25                  30          


Ile Leu Gln Glu Cys Lys Ala Gln Asn Gln Lys Leu Leu Asp Phe Leu 
        35                  40                  45              


Cys Arg Gln Gln Cys Met Glu Glu Leu Val Ser Leu Ile Thr Gln Asp 
    50                  55                  60                  


Pro Pro Leu Asp Met Glu Glu Lys Val Arg Phe Lys Tyr Pro Asn Thr 
65                  70                  75                  80  


Ala Cys Glu Leu Leu Thr Cys Asp Val Pro Gln Ile Ser Asp Arg Leu 
                85                  90                  95      


Gly Gly Asp Glu Ser Leu Leu Ser Leu Leu Tyr Asp Phe Leu Asp His 
            100                 105                 110         


Glu Pro Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Thr Ile 
        115                 120                 125             


Gly Asn Leu Ile Ala Arg Lys Thr Glu Gln Val Ile Thr Phe Leu Lys 
    130                 135                 140                 


Lys Lys Asp Lys Phe Ile Ser Leu Val Leu Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Leu Met Asp Leu Leu Leu Arg Leu Val Ser Cys Val Glu Pro Ala 
                165                 170                 175     


Gly Leu Arg Gln Asp Val Leu His Trp Leu Asn Glu Glu Lys Val Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Leu Ile His Pro Ser Gln Asp Glu Asp Arg Gln 
        195                 200                 205             


Ser Asn Ala Ser Gln Thr Leu Cys Asp Ile Val Arg Leu Gly Arg Asp 
    210                 215                 220                 


Gln Gly Ser Gln Leu Gln Glu Ala Leu Glu Pro Asp Pro Leu Leu Thr 
225                 230                 235                 240 


Ala Leu Glu Ser Arg Gln Asp Cys Val Glu Gln Leu Leu Lys Asn Met 
                245                 250                 255     


Phe Asp Gly Asp Arg Thr Glu Ser Cys Leu Val Ser Gly Thr Gln Val 
            260                 265                 270         


Leu Leu Thr Leu Leu Glu Thr Arg Arg Val Gly Thr Glu Gly Leu Val 
        275                 280                 285             


Asp Ser Phe Ser Gln Gly Leu Glu Arg Ser Tyr Ala Val Ser Ser Ser 
    290                 295                 300                 


Val Leu His Gly Ile Glu Pro Arg Leu Lys Asp Phe His Gln Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Pro Lys Lys Lys Ala Ile Leu Thr Thr Ile Gly Val Leu 
                325                 330                 335     


Glu Glu Pro Leu Gly Asn Ala Arg Leu His Gly Ala Arg Leu Met Ala 
            340                 345                 350         


Ala Leu Leu His Thr Asn Thr Pro Ser Ile Asn Gln Glu Leu Cys Arg 
        355                 360                 365             


Leu Asn Thr Met Asp Leu Leu Leu Asp Leu Phe Phe Lys Tyr Thr Trp 
    370                 375                 380                 


Asn Asn Phe Leu His Phe Gln Val Glu Leu Cys Ile Ala Ala Ile Leu 
385                 390                 395                 400 


Ser His Ala Ala Arg Glu Glu Arg Thr Glu Ala Ser Gly Ser Glu Ser 
                405                 410                 415     


Arg Val Glu Pro Pro His Glu Asn Gly Asn Arg Ser Leu Glu Thr Pro 
            420                 425                 430         


Gln Pro Ala Ala Ser Leu Pro Asp Asn Thr Met Val Thr His Leu Phe 
        435                 440                 445             


Gln Lys Cys Cys Leu Val Gln Arg Ile Leu Glu Ala Trp Glu Ala Asn 
    450                 455                 460                 


Asp His Thr Gln Ala Ala Gly Gly Met Arg Arg Gly Asn Met Gly His 
465                 470                 475                 480 


Leu Thr Arg Ile Ala Asn Ala Val Val Gln Asn Leu Glu Arg Gly Pro 
                485                 490                 495     


Val Gln Thr His Ile Ser Glu Val Ile Arg Gly Leu Pro Ala Asp Cys 
            500                 505                 510         


Arg Gly Arg Trp Glu Ser Phe Val Glu Glu Thr Leu Thr Glu Thr Asn 
        515                 520                 525             


Arg Arg Asn Thr Val Asp Leu Ala Phe Ser Asp Tyr Gln Ile Gln Gln 
    530                 535                 540                 


Met Thr Ala Asn Phe Val Asp Gln Phe Gly Phe Asn Asp Glu Glu Phe 
545                 550                 555                 560 


Ala Asp Gln Asp Asp Asn Ile Asn Ala Pro Phe Asp Arg Ile Ala Glu 
                565                 570                 575     


Ile Asn Phe Asn Ile Asp Ala Asp Glu Asp Ser Pro Ser Ala Ala Leu 
            580                 585                 590         


Phe Glu Ala Cys Cys Ser Asp Arg Ile Gln Pro Phe Asp Asp Asp Glu 
        595                 600                 605             


Asp Glu Asp Ile Trp Glu Asp Ser Asp Thr Arg Cys Ala Ala Arg Val 
    610                 615                 620                 


Met Ala Arg Pro Arg Phe Gly Ala Pro His Ala Ser Glu Ser Cys Ser 
625                 630                 635                 640 


Lys Asn Gly Pro Glu Arg Gly Gly Gln Asp Gly Lys Ala Ser Leu Glu 
                645                 650                 655     


Ala His Arg Asp Ala Pro Gly Ala Gly Ala Pro Pro Ala Pro Gly Lys 
            660                 665                 670         


Lys Glu Ala Pro Pro Val Glu Gly Asp Ser Glu Gly Ala Met Trp Thr 
        675                 680                 685             


Ala Val Phe Asp Glu Pro Ala Asn Ser Thr Pro Thr Ala Pro Gly Val 
    690                 695                 700                 


Val Arg Asp Val Gly Ser Ser Val Trp Ala Ala Gly Thr Ser Ala Pro 
705                 710                 715                 720 


Glu Glu Lys Gly Trp Ala Lys Phe Thr Asp Phe Gln Pro Phe Cys Cys 
                725                 730                 735     


Ser Glu Ser Gly Pro Arg Cys Ser Ser Pro Val Asp Thr Glu Cys Ser 
            740                 745                 750         


His Ala Glu Gly Ser Arg Ser Gln Gly Pro Glu Lys Ala Phe Ser Pro 
        755                 760                 765             


Ala Ser Pro Cys Ala Trp Asn Val Cys Val Thr Arg Lys Ala Pro Leu 
    770                 775                 780                 


Leu Ala Ser Asp Ser Ser Ser Ser Gly Gly Ser His Ser Glu Asp Gly 
785                 790                 795                 800 


Asp Gln Lys Ala Ala Ser Ala Met Asp Ala Val Ser Arg Gly Pro Gly 
                805                 810                 815     


Arg Glu Ala Pro Pro Leu Pro Thr Val Ala Arg Thr Glu Glu Ala Val 
            820                 825                 830         


Gly Arg Val Gly Cys Ala Asp Ser Arg Leu Leu Ser Pro Ala Cys Pro 
        835                 840                 845             


Ala Pro Lys Glu Val Thr Ala Ala Pro Ala Val Ala Val Pro Pro Glu 
    850                 855                 860                 


Ala Thr Val Ala Ile Thr Thr Ala Leu Ser Lys Ala Gly Pro Ala Ile 
865                 870                 875                 880 


Pro Thr Pro Ala Val Ser Ser Ala Leu Ala Val Ala Val Pro Leu Gly 
                885                 890                 895     


Pro Ile Met Ala Val Thr Ala Ala Pro Ala Met Val Ala Thr Leu Gly 
            900                 905                 910         


Thr Val Thr Lys Asp Gly Lys Thr Asp Ala Pro Pro Glu Gly Ala Ala 
        915                 920                 925             


Leu Asn Gly Pro Val 
    930             


<210> 6923
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6923
Met Phe Trp Lys Phe Asp Leu Asn Thr Thr Ser His Val Asp Lys Leu 
1               5                   10                  15      


Leu Asp Lys Glu His Val Thr Leu Gln Glu Leu Met Asp Glu Asp Asp 
            20                  25                  30          


Ile Leu Gln Glu Cys Lys Ala Gln Asn Gln Lys Leu Leu Asp Phe Leu 
        35                  40                  45              


Cys Arg Gln Gln Cys Met Glu Glu Leu Val Ser Leu Ile Thr Gln Asp 
    50                  55                  60                  


Pro Pro Leu Asp Met Glu Glu Lys Val Arg Phe Lys Tyr Pro Asn Thr 
65                  70                  75                  80  


Ala Cys Glu Leu Leu Thr Cys Asp Val Pro Gln Ile Ser Asp Arg Leu 
                85                  90                  95      


Gly Gly Asp Glu Ser Leu Leu Ser Leu Leu Tyr Asp Phe Leu Asp His 
            100                 105                 110         


Glu Pro Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Thr Ile 
        115                 120                 125             


Gly Asn Leu Ile Ala Arg Lys Thr Glu Gln Val Ile Thr Phe Leu Lys 
    130                 135                 140                 


Lys Lys Asp Lys Phe Ile Ser Leu Val Leu Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Leu Met Asp Leu Leu Leu Arg Leu Val Ser Cys Val Glu Pro Ala 
                165                 170                 175     


Gly Leu Arg Gln Asp Val Leu His Trp Leu Asn Glu Glu Lys Val Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Leu Ile His Pro Ser Gln Asp Glu Asp Arg Gln 
        195                 200                 205             


Ser Asn Ala Ser Gln Thr Leu Cys Asp Ile Val Arg Leu Gly Arg Asp 
    210                 215                 220                 


Gln Gly Ser Gln Leu Gln Glu Ala Leu Glu Pro Asp Pro Leu Leu Thr 
225                 230                 235                 240 


Ala Leu Glu Ser Gln Asp Cys Val Glu Gln Leu Leu Lys Asn Met Phe 
                245                 250                 255     


Asp Gly Asp Arg Thr Glu Ser Cys Leu Val Ser Gly Thr Gln Val Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Val Gly Thr Glu Gly Leu Val Asp 
        275                 280                 285             


Ser Phe Ser Gln Gly Leu Glu Arg Ser Tyr Ala Val Ser Ser Ser Val 
    290                 295                 300                 


Leu His Gly Ile Glu Pro Arg Leu Lys Asp Phe His Gln Leu Leu Leu 
305                 310                 315                 320 


Asn Pro Pro Lys Lys Lys Ala Ile Leu Thr Thr Ile Gly Val Leu Glu 
                325                 330                 335     


Glu Pro Leu Gly Asn Ala Arg Leu His Gly Ala Arg Leu Met Ala Ala 
            340                 345                 350         


Leu Leu His Thr Asn Thr Pro Ser Ile Asn Gln Glu Leu Cys Arg Leu 
        355                 360                 365             


Asn Thr Met Asp Leu Leu Leu Asp Leu Phe Phe Lys Tyr Thr Trp Asn 
    370                 375                 380                 


Asn Phe Leu His Phe Gln Val Glu Leu Cys Ile Ala Ala Ile Leu Ser 
385                 390                 395                 400 


His Ala Ala Arg Glu Glu Arg Thr Glu Ala Ser Gly Ser Glu Ser Arg 
                405                 410                 415     


Val Glu Pro Pro His Glu Asn Gly Asn Arg Ser Leu Glu Thr Pro Gln 
            420                 425                 430         


Pro Ala Ala Ser Leu Pro Asp Asn Thr Met Val Thr His Leu Phe Gln 
        435                 440                 445             


Lys Cys Cys Leu Val Gln Arg Ile Leu Glu Ala Trp Glu Ala Asn Asp 
    450                 455                 460                 


His Thr Gln Ala Ala Gly Gly Met Arg Arg Gly Asn Met Gly His Leu 
465                 470                 475                 480 


Thr Arg Ile Ala Asn Ala Val Val Gln Asn Leu Glu Arg Gly Pro Val 
                485                 490                 495     


Gln Thr His Ile Ser Glu Val Ile Arg Gly Leu Pro Ala Asp Cys Arg 
            500                 505                 510         


Gly Arg Trp Glu Ser Phe Val Glu Glu Thr Leu Thr Glu Thr Asn Arg 
        515                 520                 525             


Arg Asn Thr Val Asp Leu Ala Phe Ser Asp Tyr Gln Ile Gln Gln Met 
    530                 535                 540                 


Thr Ala Asn Phe Val Asp Gln Phe Gly Phe Asn Asp Glu Glu Phe Ala 
545                 550                 555                 560 


Asp Gln Asp Asp Asn Ile Asn Ala Pro Phe Asp Arg Ile Ala Glu Ile 
                565                 570                 575     


Asn Phe Asn Ile Asp Ala Asp Glu Asp Ser Pro Ser Ala Ala Leu Phe 
            580                 585                 590         


Glu Ala Cys Cys Ser Asp Arg Ile Gln Pro Phe Asp Asp Asp Glu Asp 
        595                 600                 605             


Glu Asp Ile Trp Glu Asp Ser Asp Thr Arg Cys Ala Ala Arg Val Met 
    610                 615                 620                 


Ala Arg Pro Arg Phe Gly Ala Pro His Ala Ser Glu Ser Cys Ser Lys 
625                 630                 635                 640 


Asn Gly Pro Glu Arg Gly Gly Gln Asp Gly Lys Ala Ser Leu Glu Ala 
                645                 650                 655     


His Arg Asp Ala Pro Gly Ala Gly Ala Pro Pro Ala Pro Gly Lys Lys 
            660                 665                 670         


Glu Ala Pro Pro Val Glu Gly Asp Ser Glu Gly Ala Met Trp Thr Ala 
        675                 680                 685             


Val Phe Asp Glu Pro Ala Asn Ser Thr Pro Thr Ala Pro Gly Val Val 
    690                 695                 700                 


Arg Asp Val Gly Ser Ser Val Trp Ala Ala Gly Thr Ser Ala Pro Glu 
705                 710                 715                 720 


Glu Lys Gly Trp Ala Lys Phe Thr Asp Phe Gln Pro Phe Cys Cys Ser 
                725                 730                 735     


Glu Ser Gly Pro Arg Cys Ser Ser Pro Val Asp Thr Glu Cys Ser His 
            740                 745                 750         


Ala Glu Gly Ser Arg Ser Gln Gly Pro Glu Lys Ala Phe Ser Pro Ala 
        755                 760                 765             


Ser Pro Cys Ala Trp Asn Val Cys Val Thr Arg Lys Ala Pro Leu Leu 
    770                 775                 780                 


Ala Ser Asp Ser Ser Ser Ser Gly Gly Ser His Ser Glu Asp Gly Asp 
785                 790                 795                 800 


Gln Lys Ala Ala Ser Ala Met Asp Ala Val Ser Arg Gly Pro Gly Arg 
                805                 810                 815     


Glu Ala Pro Pro Leu Pro Thr Val Ala Arg Thr Glu Glu Ala Val Gly 
            820                 825                 830         


Arg Val Gly Cys Ala Asp Ser Arg Leu Leu Ser Pro Ala Cys Pro Ala 
        835                 840                 845             


Pro Lys Glu Val Thr Ala Ala Pro Ala Val Ala Val Pro Pro Glu Ala 
    850                 855                 860                 


Thr Val Ala Ile Thr Thr Ala Leu Ser Lys Ala Gly Pro Ala Ile Pro 
865                 870                 875                 880 


Thr Pro Ala Val Ser Ser Ala Leu Ala Val Ala Val Pro Leu Gly Pro 
                885                 890                 895     


Ile Met Ala Val Thr Ala Ala Pro Ala Met Val Ala Thr Leu Gly Thr 
            900                 905                 910         


Val Thr Lys Asp Gly Lys Thr Asp Ala Pro Pro Glu Gly Ala Ala Leu 
        915                 920                 925             


Asn Gly Pro Val 
    930         


<210> 6924
<211> 262
<212> PRT
<213> Homo sapiens

<400> 6924
Met Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly 
            20                  25                  30          


Gln Cys Pro Trp Arg Gly Ala Gly Ser Phe Leu Asp Pro Glu Ile Lys 
        35                  40                  45              


Ala Phe Leu Glu Glu Asn Thr Glu Val Thr Ser Ser Gly Ser Leu Thr 
    50                  55                  60                  


Pro Glu Ile Gln Leu Arg Leu Leu Thr Pro Arg Cys Lys Phe Trp Trp 
65                  70                  75                  80  


Glu Arg Ala Asp Leu Trp Pro His Ser Asp Pro Tyr Trp Ala Ile Tyr 
                85                  90                  95      


Trp Pro Gly Gly Gln Ala Leu Ser Arg Tyr Leu Leu Asp Asn Pro Asp 
            100                 105                 110         


Val Val Arg Gly Lys Ser Val Leu Asp Leu Gly Ser Gly Cys Gly Ala 
        115                 120                 125             


Thr Ala Ile Ala Ala Lys Met Ser Gly Ala Ser Arg Ile Leu Ala Asn 
    130                 135                 140                 


Asp Ile Asp Pro Ile Ala Gly Met Ala Ile Thr Leu Asn Cys Glu Leu 
145                 150                 155                 160 


Asn Arg Leu Asn Pro Phe Pro Ile Leu Ile Gln Asn Ile Leu Asn Leu 
                165                 170                 175     


Glu Gln Asp Lys Trp Asp Leu Val Val Leu Gly Asp Met Phe Tyr Asp 
            180                 185                 190         


Glu Asp Leu Ala Asp Ser Leu His Gln Trp Leu Lys Lys Cys Phe Trp 
        195                 200                 205             


Thr Tyr Arg Thr Arg Val Leu Ile Gly Asp Pro Gly Arg Pro Gln Phe 
    210                 215                 220                 


Ser Gly His Ser Ile Gln His His Leu His Lys Val Val Glu Tyr Ser 
225                 230                 235                 240 


Leu Leu Glu Ser Thr Arg Gln Glu Asn Ser Gly Leu Thr Thr Ser Thr 
                245                 250                 255     


Val Trp Gly Phe Gln Pro 
            260         


<210> 6925
<211> 905
<212> PRT
<213> Homo sapiens

<400> 6925
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Thr Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Thr Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Thr Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Thr Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Thr Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Thr Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Thr Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Thr Thr Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys 
        435                 440                 445             


Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro 
            500                 505                 510         


Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser 
        515                 520                 525             


Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Thr 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Ala Ile Pro Pro Gly Lys 
        675                 680                 685             


Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala Lys Gly Ser 
    690                 695                 700                 


Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser Val Thr Ile 
705                 710                 715                 720 


Asn Thr Ala Pro Phe Gln Ala Met Gln Thr Val Phe Asn Val Asn Ala 
                725                 730                 735     


Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro Tyr Ser 
            740                 745                 750         


Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln Thr Pro Pro 
        755                 760                 765             


Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Thr Val His Ser Gln 
    770                 775                 780                 


Glu Thr Ala Gln Thr Asn Val Phe Pro Arg Pro Thr Gln Pro Phe Val 
785                 790                 795                 800 


Asn Ser Arg Gly Ser Val Arg Gly Cys Thr Arg Gly Gly Arg Leu Ile 
                805                 810                 815     


Thr Asn Ser Tyr Arg Ser Pro Gly Gly Tyr Lys Gly Phe Asp Thr Tyr 
            820                 825                 830         


Arg Gly Leu Pro Ser Ile Ser Asn Gly Asn Tyr Ser Gln Leu Gln Phe 
        835                 840                 845             


Gln Ala Arg Glu Tyr Ser Gly Ala Pro Tyr Ser Gln Arg Asp Asn Phe 
    850                 855                 860                 


Gln Gln Cys Tyr Lys Arg Gly Gly Thr Ser Gly Gly Pro Arg Ala Asn 
865                 870                 875                 880 


Ser Arg Ala Asn Cys Phe Ile Met Arg Asn Ser Leu Leu Leu Ile Lys 
                885                 890                 895     


Gln Gln Gly Gly Val Ile Leu Leu Arg 
            900                 905 


<210> 6926
<211> 368
<212> PRT
<213> Homo sapiens

<400> 6926
Met Ser Leu Phe Gly Thr Thr Ser Gly Phe Gly Thr Ser Gly Thr Ser 
1               5                   10                  15      


Met Phe Gly Ser Ala Thr Thr Asp Asn His Asn Pro Met Lys Asp Ile 
            20                  25                  30          


Glu Val Thr Ser Ser Pro Asp Asp Ser Ile Gly Cys Leu Ser Phe Ser 
        35                  40                  45              


Pro Pro Thr Leu Pro Gly Asn Phe Leu Ile Ala Gly Ser Trp Ala Asn 
    50                  55                  60                  


Asp Val Arg Cys Trp Glu Val Gln Asp Ser Gly Gln Thr Ile Pro Lys 
65                  70                  75                  80  


Ala Gln Gln Met His Thr Gly Pro Val Leu Asp Val Cys Trp Ser Asp 
                85                  90                  95      


Asp Gly Ser Lys Val Phe Thr Ala Ser Cys Asp Lys Thr Ala Lys Met 
            100                 105                 110         


Trp Asp Leu Ser Ser Asn Gln Ala Ile Gln Ile Ala Gln His Asp Ala 
        115                 120                 125             


Pro Val Lys Thr Ile His Trp Ile Lys Ala Pro Asn Tyr Ser Cys Val 
    130                 135                 140                 


Met Thr Gly Ser Trp Asp Lys Thr Leu Lys Phe Trp Asp Thr Arg Ser 
145                 150                 155                 160 


Ser Asn Pro Met Met Val Leu Gln Leu Pro Glu Arg Cys Tyr Cys Ala 
                165                 170                 175     


Asp Val Ile Tyr Pro Met Ala Val Val Ala Thr Ala Glu Arg Gly Leu 
            180                 185                 190         


Ile Val Tyr Gln Leu Glu Asn Gln Pro Ser Glu Phe Arg Arg Ile Glu 
        195                 200                 205             


Ser Pro Leu Lys His Gln His Arg Cys Val Ala Ile Phe Lys Asp Lys 
    210                 215                 220                 


Gln Asn Lys Pro Thr Gly Phe Ala Leu Gly Ser Ile Glu Gly Arg Val 
225                 230                 235                 240 


Ala Ile His Tyr Ile Asn Pro Pro Asn Pro Ala Lys Asp Asn Phe Thr 
                245                 250                 255     


Phe Lys Cys His Arg Ser Asn Gly Thr Asn Thr Ser Ala Pro Gln Asp 
            260                 265                 270         


Ile Tyr Ala Val Asn Gly Ile Ala Phe His Pro Val His Gly Thr Leu 
        275                 280                 285             


Ala Thr Val Gly Ser Asp Gly Arg Phe Ser Phe Trp Asp Lys Asp Ala 
    290                 295                 300                 


Arg Thr Lys Leu Lys Thr Ser Glu Gln Leu Asp Gln Pro Ile Ser Ala 
305                 310                 315                 320 


Cys Cys Phe Asn His Asn Gly Asn Ile Phe Ala Tyr Ala Ser Ser Tyr 
                325                 330                 335     


Asp Trp Ser Lys Gly His Glu Phe Tyr Asn Pro Gln Lys Lys Asn Tyr 
            340                 345                 350         


Ile Phe Leu Arg Asn Ala Ala Glu Glu Leu Lys Pro Arg Asn Lys Lys 
        355                 360                 365             


<210> 6927
<211> 368
<212> PRT
<213> Homo sapiens

<400> 6927
Met Ser Leu Phe Gly Thr Thr Ser Gly Phe Gly Thr Ser Gly Thr Ser 
1               5                   10                  15      


Met Phe Gly Ser Ala Thr Thr Asp Asn His Asn Pro Met Lys Asp Ile 
            20                  25                  30          


Glu Val Thr Ser Ser Pro Asp Asp Ser Ile Gly Cys Leu Ser Phe Ser 
        35                  40                  45              


Pro Pro Thr Leu Pro Gly Asn Phe Leu Ile Ala Gly Ser Trp Ala Asn 
    50                  55                  60                  


Asp Val Arg Cys Trp Glu Val Gln Asp Ser Gly Gln Thr Ile Pro Lys 
65                  70                  75                  80  


Ala Gln Gln Met His Thr Gly Pro Val Leu Asp Val Cys Trp Ser Asp 
                85                  90                  95      


Asp Gly Ser Lys Val Phe Thr Ala Ser Cys Asp Lys Thr Ala Lys Met 
            100                 105                 110         


Trp Asp Leu Ser Ser Asn Gln Ala Ile Gln Ile Ala Gln His Asp Ala 
        115                 120                 125             


Pro Val Lys Thr Ile His Trp Ile Lys Ala Pro Asn Tyr Ser Cys Val 
    130                 135                 140                 


Met Thr Gly Ser Trp Asp Lys Thr Leu Lys Phe Trp Asp Thr Arg Ser 
145                 150                 155                 160 


Ser Asn Pro Met Met Val Leu Gln Leu Pro Glu Arg Cys Tyr Cys Ala 
                165                 170                 175     


Asp Val Ile Tyr Pro Met Ala Val Val Ala Thr Ala Glu Arg Gly Leu 
            180                 185                 190         


Ile Val Tyr Gln Leu Glu Asn Gln Pro Ser Glu Phe Arg Arg Ile Glu 
        195                 200                 205             


Ser Pro Leu Lys His Gln His Arg Cys Val Ala Ile Phe Lys Asp Lys 
    210                 215                 220                 


Gln Asn Lys Pro Thr Gly Phe Ala Leu Gly Ser Ile Glu Gly Arg Val 
225                 230                 235                 240 


Ala Ile His Tyr Ile Asn Pro Pro Asn Pro Ala Lys Asp Asn Phe Thr 
                245                 250                 255     


Phe Lys Cys His Arg Ser Asn Gly Thr Asn Thr Ser Ala Pro Gln Asp 
            260                 265                 270         


Ile Tyr Ala Val Asn Gly Ile Ala Phe His Pro Val His Gly Thr Leu 
        275                 280                 285             


Ala Thr Val Gly Ser Asp Gly Arg Phe Ser Phe Trp Asp Lys Asp Ala 
    290                 295                 300                 


Arg Thr Lys Leu Lys Thr Ser Glu Gln Leu Asp Gln Pro Ile Ser Ala 
305                 310                 315                 320 


Cys Cys Phe Asn His Asn Gly Asn Ile Phe Ala Tyr Ala Ser Ser Tyr 
                325                 330                 335     


Asp Trp Ser Lys Gly His Glu Phe Tyr Asn Pro Gln Lys Lys Asn Tyr 
            340                 345                 350         


Ile Phe Leu Arg Asn Ala Ala Glu Glu Leu Lys Pro Arg Asn Lys Lys 
        355                 360                 365             


<210> 6928
<211> 914
<212> PRT
<213> Homo sapiens

<400> 6928
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser 
        35                  40                  45              


Ser Pro Ile Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro 
    50                  55                  60                  


Ser Lys Leu Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp 
65                  70                  75                  80  


Arg Glu Ile Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys 
                85                  90                  95      


Gln Gln Gln Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys 
            100                 105                 110         


Pro Val Ser Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln 
        115                 120                 125             


Ile Ile Tyr Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile 
    130                 135                 140                 


Phe Glu Gly Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro 
145                 150                 155                 160 


Ser Asp Thr Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met 
                165                 170                 175     


Arg Lys Lys Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys 
            180                 185                 190         


Gln Arg Glu Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala 
        195                 200                 205             


Trp Glu Lys Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala 
    210                 215                 220                 


Lys Glu Ser Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile 
225                 230                 235                 240 


Arg Lys Gln Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg 
                245                 250                 255     


Gly Ala Gly Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser 
            260                 265                 270         


Glu Ile Ile Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met 
        275                 280                 285             


Arg Gln Leu Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg 
    290                 295                 300                 


Arg Val Lys Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys 
305                 310                 315                 320 


Val Tyr Lys Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys 
                325                 330                 335     


Glu Ile Phe Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu 
            340                 345                 350         


Ile Ala Ser Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr 
        355                 360                 365             


Tyr Tyr Leu Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg 
    370                 375                 380                 


Asn Tyr Gly Lys Arg Arg Gly Arg Asn Gln Gln Ile Ala Arg Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr 
                405                 410                 415     


Glu Lys Lys Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys 
            420                 425                 430         


Glu Asp Ser Lys Glu Asn Thr Lys Glu Lys Asp Lys Ile Asp Gly Thr 
        435                 440                 445             


Ala Glu Glu Thr Glu Glu Arg Glu Gln Ala Thr Pro Arg Gly Arg Lys 
    450                 455                 460                 


Thr Ala Asn Ser Gln Gly Arg Arg Lys Gly Arg Ile Thr Arg Ser Met 
465                 470                 475                 480 


Thr Asn Glu Ala Ala Ala Ala Ser Ala Ala Ala Ala Ala Ala Thr Glu 
                485                 490                 495     


Glu Pro Pro Pro Pro Leu Pro Pro Pro Pro Glu Pro Ile Ser Thr Glu 
            500                 505                 510         


Pro Val Glu Thr Ser Arg Trp Thr Glu Glu Glu Met Glu Val Ala Lys 
        515                 520                 525             


Lys Gly Leu Val Glu His Gly Arg Asn Trp Ala Ala Ile Ala Lys Met 
    530                 535                 540                 


Val Gly Thr Lys Ser Glu Ala Gln Cys Lys Asn Phe Tyr Phe Asn Tyr 
545                 550                 555                 560 


Lys Arg Arg His Asn Leu Asp Asn Leu Leu Gln Gln His Lys Gln Lys 
                565                 570                 575     


Thr Ser Arg Lys Pro Arg Glu Glu Arg Asp Val Ser Gln Cys Glu Ser 
            580                 585                 590         


Val Ala Ser Thr Val Ser Ala Gln Glu Asp Glu Asp Ile Glu Ala Ser 
        595                 600                 605             


Asn Glu Glu Glu Asn Pro Glu Asp Ser Glu Gly Ala Glu Asn Ser Ser 
    610                 615                 620                 


Asp Thr Glu Ser Ala Pro Ser Pro Ser Pro Val Glu Ala Val Lys Pro 
625                 630                 635                 640 


Ser Glu Asp Ser Pro Glu Asn Ala Thr Ser Arg Gly Asn Thr Glu Pro 
                645                 650                 655     


Ala Val Glu Leu Glu Pro Thr Thr Glu Thr Ala Pro Ser Thr Ser Pro 
            660                 665                 670         


Ser Leu Ala Val Pro Ser Thr Lys Pro Ala Glu Asp Glu Ser Val Glu 
        675                 680                 685             


Thr Gln Val Asn Asp Ser Ile Ser Ala Glu Thr Ala Glu Gln Met Asp 
    690                 695                 700                 


Val Asp Gln Gln Glu His Ser Ala Glu Glu Gly Ser Val Cys Asp Pro 
705                 710                 715                 720 


Pro Pro Ala Thr Lys Ala Asp Ser Val Asp Val Glu Val Arg Val Pro 
                725                 730                 735     


Glu Asn His Ala Ser Lys Val Glu Gly Asp Asn Thr Lys Glu Arg Asp 
            740                 745                 750         


Leu Asp Arg Ala Ser Glu Lys Val Glu Pro Arg Asp Glu Asp Leu Val 
        755                 760                 765             


Val Ala Gln Gln Ile Asn Ala Gln Arg Pro Glu Pro Gln Ser Asp Asn 
    770                 775                 780                 


Asp Ser Ser Ala Thr Cys Ser Ala Asp Glu Asp Val Asp Gly Glu Pro 
785                 790                 795                 800 


Glu Arg Gln Arg Met Phe Pro Met Asp Ser Lys Pro Ser Leu Leu Asn 
                805                 810                 815     


Pro Thr Gly Ser Ile Leu Val Ser Ser Pro Leu Lys Pro Asn Pro Leu 
            820                 825                 830         


Asp Leu Pro Gln Leu Gln His Arg Ala Ala Val Ile Pro Pro Met Val 
        835                 840                 845             


Ser Cys Thr Pro Cys Asn Ile Pro Ile Gly Thr Pro Val Ser Gly Tyr 
    850                 855                 860                 


Ala Leu Tyr Gln Arg His Ile Lys Ala Met His Glu Ser Ala Leu Leu 
865                 870                 875                 880 


Glu Glu Gln Arg Gln Arg Gln Glu Gln Ile Asp Leu Glu Cys Arg Ser 
                885                 890                 895     


Ser Thr Ser Pro Cys Gly Thr Ser Lys Ser Pro Asn Arg Glu Trp Glu 
            900                 905                 910         


Gly Arg 
        


<210> 6929
<211> 2343
<212> PRT
<213> Homo sapiens

<400> 6929
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser 
        35                  40                  45              


Ser Pro Ile Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro 
    50                  55                  60                  


Ser Lys Leu Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp 
65                  70                  75                  80  


Arg Glu Ile Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys 
                85                  90                  95      


Gln Gln Gln Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys 
            100                 105                 110         


Pro Val Ser Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln 
        115                 120                 125             


Ile Ile Tyr Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile 
    130                 135                 140                 


Phe Glu Gly Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro 
145                 150                 155                 160 


Ser Asp Thr Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met 
                165                 170                 175     


Arg Lys Lys Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys 
            180                 185                 190         


Gln Arg Glu Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala 
        195                 200                 205             


Trp Glu Lys Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala 
    210                 215                 220                 


Lys Glu Ser Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile 
225                 230                 235                 240 


Arg Lys Gln Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg 
                245                 250                 255     


Gly Ala Gly Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser 
            260                 265                 270         


Glu Ile Ile Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met 
        275                 280                 285             


Arg Gln Leu Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg 
    290                 295                 300                 


Arg Val Lys Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys 
305                 310                 315                 320 


Val Tyr Lys Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys 
                325                 330                 335     


Glu Ile Phe Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu 
            340                 345                 350         


Ile Ala Ser Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr 
        355                 360                 365             


Tyr Tyr Leu Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg 
    370                 375                 380                 


Asn Tyr Gly Lys Arg Arg Gly Arg Asn Gln Gln Ile Ala Arg Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr 
                405                 410                 415     


Glu Lys Lys Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys 
            420                 425                 430         


Glu Asp Ser Lys Glu Asn Thr Lys Glu Lys Asp Lys Ile Asp Gly Thr 
        435                 440                 445             


Ala Glu Glu Thr Glu Glu Arg Glu Gln Ala Thr Pro Arg Gly Arg Lys 
    450                 455                 460                 


Thr Ala Asn Ser Gln Gly Arg Arg Lys Gly Arg Ile Thr Arg Ser Met 
465                 470                 475                 480 


Thr Asn Glu Ala Ala Ala Ala Ser Ala Ala Ala Ala Ala Ala Thr Glu 
                485                 490                 495     


Glu Pro Pro Pro Pro Leu Pro Pro Pro Pro Glu Pro Ile Ser Thr Glu 
            500                 505                 510         


Pro Val Glu Thr Ser Arg Trp Thr Glu Glu Glu Met Glu Val Ala Lys 
        515                 520                 525             


Lys Gly Leu Val Glu His Gly Arg Asn Trp Ala Ala Ile Ala Lys Met 
    530                 535                 540                 


Val Gly Thr Lys Ser Glu Ala Gln Cys Lys Asn Phe Tyr Phe Asn Tyr 
545                 550                 555                 560 


Lys Arg Arg His Asn Leu Asp Asn Leu Leu Gln Gln His Lys Gln Lys 
                565                 570                 575     


Thr Ser Arg Lys Pro Arg Glu Glu Arg Asp Val Ser Gln Cys Glu Ser 
            580                 585                 590         


Val Ala Ser Thr Val Ser Ala Gln Glu Asp Glu Asp Ile Glu Ala Ser 
        595                 600                 605             


Asn Glu Glu Glu Asn Pro Glu Asp Ser Glu Gly Ala Glu Asn Ser Ser 
    610                 615                 620                 


Asp Thr Glu Ser Ala Pro Ser Pro Ser Pro Val Glu Ala Val Lys Pro 
625                 630                 635                 640 


Ser Glu Asp Ser Pro Glu Asn Ala Thr Ser Arg Gly Asn Thr Glu Pro 
                645                 650                 655     


Ala Val Glu Leu Glu Pro Thr Thr Glu Thr Ala Pro Ser Thr Ser Pro 
            660                 665                 670         


Ser Leu Ala Val Pro Ser Thr Lys Pro Ala Glu Asp Glu Ser Val Glu 
        675                 680                 685             


Thr Gln Val Asn Asp Ser Ile Ser Ala Glu Thr Ala Glu Gln Met Asp 
    690                 695                 700                 


Val Asp Gln Gln Glu His Ser Ala Glu Glu Gly Ser Val Cys Asp Pro 
705                 710                 715                 720 


Pro Pro Ala Thr Lys Ala Asp Ser Val Asp Val Glu Val Arg Val Pro 
                725                 730                 735     


Glu Asn His Ala Ser Lys Val Glu Gly Asp Asn Thr Lys Glu Arg Asp 
            740                 745                 750         


Leu Asp Arg Ala Ser Glu Lys Val Glu Pro Arg Asp Glu Asp Leu Val 
        755                 760                 765             


Val Ala Gln Gln Ile Asn Ala Gln Arg Pro Glu Pro Gln Ser Asp Asn 
    770                 775                 780                 


Asp Ser Ser Ala Thr Cys Ser Ala Asp Glu Asp Val Asp Gly Glu Pro 
785                 790                 795                 800 


Glu Arg Gln Arg Met Phe Pro Met Asp Ser Lys Pro Ser Leu Leu Asn 
                805                 810                 815     


Pro Thr Gly Ser Ile Leu Val Ser Ser Pro Leu Lys Pro Asn Pro Leu 
            820                 825                 830         


Asp Leu Pro Gln Leu Gln His Arg Ala Ala Val Ile Pro Pro Met Val 
        835                 840                 845             


Ser Cys Thr Pro Cys Asn Ile Pro Ile Gly Thr Pro Val Ser Gly Tyr 
    850                 855                 860                 


Ala Leu Tyr Gln Arg His Ile Lys Ala Met His Glu Ser Ala Leu Leu 
865                 870                 875                 880 


Glu Glu Gln Arg Gln Arg Gln Glu Gln Ile Asp Leu Glu Cys Arg Ser 
                885                 890                 895     


Ser Thr Ser Pro Cys Gly Thr Ser Lys Ser Pro Asn Arg Glu Trp Glu 
            900                 905                 910         


Val Leu Gln Pro Ala Pro His Gln Val Ile Thr Asn Leu Pro Glu Gly 
        915                 920                 925             


Val Arg Leu Pro Thr Thr Arg Pro Thr Arg Pro Pro Pro Pro Leu Ile 
    930                 935                 940                 


Pro Ser Ser Lys Thr Thr Val Ala Ser Glu Lys Pro Ser Phe Ile Met 
945                 950                 955                 960 


Gly Gly Ser Ile Ser Gln Gly Thr Pro Gly Thr Tyr Leu Thr Ser His 
                965                 970                 975     


Asn Gln Ala Ser Tyr Thr Gln Glu Thr Pro Lys Pro Ser Val Gly Ser 
            980                 985                 990         


Ile Ser Leu Gly Leu Pro Arg Gln  Gln Glu Ser Ala Lys  Ser Ala Thr 
        995                 1000                 1005             


Leu Pro  Tyr Ile Lys Gln Glu  Glu Phe Ser Pro Arg  Ser Gln Asn 
    1010                 1015                 1020             


Ser Gln  Pro Glu Gly Leu Leu  Val Arg Ala Gln His  Glu Gly Val 
    1025                 1030                 1035             


Val Arg  Gly Thr Ala Gly Ala  Ile Gln Glu Gly Ser  Ile Thr Arg 
    1040                 1045                 1050             


Gly Thr  Pro Thr Ser Lys Ile  Ser Val Glu Ser Ile  Pro Ser Leu 
    1055                 1060                 1065             


Arg Gly  Ser Ile Thr Gln Gly  Thr Pro Ala Leu Pro  Gln Thr Gly 
    1070                 1075                 1080             


Ile Pro  Thr Glu Ala Leu Val  Lys Gly Ser Ile Ser  Arg Met Pro 
    1085                 1090                 1095             


Ile Glu  Asp Ser Ser Pro Glu  Lys Gly Arg Glu Glu  Ala Ala Ser 
    1100                 1105                 1110             


Lys Gly  His Val Ile Tyr Glu  Gly Lys Ser Gly His  Ile Leu Ser 
    1115                 1120                 1125             


Tyr Asp  Asn Ile Lys Asn Ala  Arg Glu Gly Thr Arg  Ser Pro Arg 
    1130                 1135                 1140             


Thr Ala  His Glu Ile Ser Leu  Lys Arg Ser Tyr Glu  Ser Val Glu 
    1145                 1150                 1155             


Gly Asn  Ile Lys Gln Gly Met  Ser Met Arg Glu Ser  Pro Val Ser 
    1160                 1165                 1170             


Ala Pro  Leu Glu Gly Leu Ile  Cys Arg Ala Leu Pro  Arg Gly Ser 
    1175                 1180                 1185             


Pro His  Ser Asp Leu Lys Glu  Arg Thr Val Leu Ser  Gly Ser Ile 
    1190                 1195                 1200             


Met Gln  Gly Thr Pro Arg Ala  Thr Thr Glu Ser Phe  Glu Asp Gly 
    1205                 1210                 1215             


Leu Lys  Tyr Pro Lys Gln Ile  Lys Arg Glu Ser Pro  Pro Ile Arg 
    1220                 1225                 1230             


Ala Phe  Glu Gly Ala Ile Thr  Lys Gly Lys Pro Tyr  Asp Gly Ile 
    1235                 1240                 1245             


Thr Thr  Ile Lys Glu Met Gly  Arg Ser Ile His Glu  Ile Pro Arg 
    1250                 1255                 1260             


Gln Asp  Ile Leu Thr Gln Glu  Ser Arg Lys Thr Pro  Glu Val Val 
    1265                 1270                 1275             


Gln Ser  Thr Arg Pro Ile Ile  Glu Gly Ser Ile Ser  Gln Gly Thr 
    1280                 1285                 1290             


Pro Ile  Lys Phe Asp Asn Asn  Ser Gly Gln Ser Ala  Ile Lys His 
    1295                 1300                 1305             


Asn Val  Lys Ser Leu Ile Thr  Gly Pro Ser Lys Leu  Ser Arg Gly 
    1310                 1315                 1320             


Met Pro  Pro Leu Glu Ile Val  Pro Glu Asn Ile Lys  Val Val Glu 
    1325                 1330                 1335             


Arg Gly  Lys Tyr Glu Asp Val  Lys Ala Gly Glu Thr  Val Arg Ser 
    1340                 1345                 1350             


Arg His  Thr Ser Val Val Ser  Ser Gly Pro Ser Val  Leu Arg Ser 
    1355                 1360                 1365             


Thr Leu  His Glu Ala Pro Lys  Ala Gln Leu Ser Pro  Gly Ile Tyr 
    1370                 1375                 1380             


Asp Asp  Thr Ser Ala Arg Arg  Thr Pro Val Ser Tyr  Gln Asn Thr 
    1385                 1390                 1395             


Met Ser  Arg Gly Ser Pro Met  Met Asn Arg Thr Ser  Asp Val Ser 
    1400                 1405                 1410             


Ser Asn  Lys Ser Thr Asn His  Glu Arg Lys Ser Thr  Leu Thr Pro 
    1415                 1420                 1425             


Thr Gln  Arg Glu Ser Ile Pro  Ala Lys Ser Pro Val  Pro Gly Val 
    1430                 1435                 1440             


Asp Pro  Val Val Ser His Ser  Pro Phe Asp Pro His  His Arg Gly 
    1445                 1450                 1455             


Ser Thr  Ala Gly Glu Val Tyr  Arg Ser His Leu Pro  Thr His Leu 
    1460                 1465                 1470             


Asp Pro  Ala Met Pro Phe His  Arg Ala Leu Asp Pro  Ala Ala Ala 
    1475                 1480                 1485             


Tyr Leu  Phe Gln Arg Gln Leu  Ser Pro Thr Pro Gly  Tyr Pro Ser 
    1490                 1495                 1500             


Gln Tyr  Gln Leu Tyr Ala Met  Glu Asn Thr Arg Gln  Thr Ile Leu 
    1505                 1510                 1515             


Asn Asp  Tyr Ile Thr Ser Gln  Gln Met Gln Val Asn  Leu Arg Pro 
    1520                 1525                 1530             


Asp Val  Ala Arg Gly Leu Ser  Pro Arg Glu Gln Pro  Leu Gly Leu 
    1535                 1540                 1545             


Pro Tyr  Pro Ala Thr Arg Gly  Ile Ile Asp Leu Thr  Asn Met Pro 
    1550                 1555                 1560             


Pro Thr  Ile Leu Val Pro His  Pro Gly Gly Thr Ser  Thr Pro Pro 
    1565                 1570                 1575             


Met Asp  Arg Ile Thr Tyr Ile  Pro Gly Thr Gln Ile  Thr Phe Pro 
    1580                 1585                 1590             


Pro Arg  Pro Tyr Asn Ser Ala  Ser Met Ser Pro Gly  His Pro Thr 
    1595                 1600                 1605             


His Leu  Ala Ala Ala Ala Ser  Ala Glu Arg Glu Arg  Glu Arg Glu 
    1610                 1615                 1620             


Arg Glu  Lys Glu Arg Glu Arg  Glu Arg Ile Ala Ala  Ala Ser Ser 
    1625                 1630                 1635             


Asp Leu  Tyr Leu Arg Pro Gly  Ser Glu Gln Pro Gly  Arg Pro Gly 
    1640                 1645                 1650             


Ser His  Gly Tyr Val Arg Ser  Pro Ser Pro Ser Val  Arg Thr Gln 
    1655                 1660                 1665             


Glu Thr  Met Leu Gln Gln Arg  Pro Ser Val Phe Gln  Gly Thr Asn 
    1670                 1675                 1680             


Gly Thr  Ser Val Ile Thr Pro  Leu Asp Pro Thr Ala  Gln Leu Arg 
    1685                 1690                 1695             


Ile Met  Pro Leu Pro Ala Gly  Gly Pro Ser Ile Ser  Gln Gly Leu 
    1700                 1705                 1710             


Pro Ala  Ser Arg Tyr Asn Thr  Ala Ala Asp Ala Leu  Ala Ala Leu 
    1715                 1720                 1725             


Val Asp  Ala Ala Ala Ser Ala  Pro Gln Met Asp Val  Ser Lys Thr 
    1730                 1735                 1740             


Lys Glu  Ser Lys His Glu Ala  Ala Arg Leu Glu Glu  Asn Leu Arg 
    1745                 1750                 1755             


Ser Arg  Ser Ala Ala Val Ser  Glu Gln Gln Gln Leu  Glu Gln Lys 
    1760                 1765                 1770             


Thr Leu  Glu Val Glu Lys Arg  Ser Val Gln Cys Leu  Tyr Thr Ser 
    1775                 1780                 1785             


Ser Ala  Phe Pro Ser Gly Lys  Pro Gln Pro His Ser  Ser Val Val 
    1790                 1795                 1800             


Tyr Ser  Glu Ala Gly Lys Asp  Lys Gly Pro Pro Pro  Lys Ser Arg 
    1805                 1810                 1815             


Tyr Glu  Glu Glu Leu Arg Thr  Arg Gly Lys Thr Thr  Ile Thr Ala 
    1820                 1825                 1830             


Ala Asn  Phe Ile Asp Val Ile  Ile Thr Arg Gln Ile  Ala Ser Asp 
    1835                 1840                 1845             


Lys Asp  Ala Arg Glu Arg Gly  Ser Gln Ser Ser Asp  Ser Ser Ser 
    1850                 1855                 1860             


Ser Leu  Ser Ser His Arg Tyr  Glu Thr Pro Ser Asp  Ala Ile Glu 
    1865                 1870                 1875             


Val Ile  Ser Pro Ala Ser Ser  Pro Ala Pro Pro Gln  Glu Lys Leu 
    1880                 1885                 1890             


Gln Thr  Tyr Gln Pro Glu Val  Val Lys Ala Asn Gln  Ala Glu Asn 
    1895                 1900                 1905             


Asp Pro  Thr Arg Gln Tyr Glu  Gly Pro Leu His His  Tyr Arg Pro 
    1910                 1915                 1920             


Gln Gln  Glu Ser Pro Ser Pro  Gln Gln Gln Leu Pro  Pro Ser Ser 
    1925                 1930                 1935             


Gln Ala  Glu Gly Met Gly Gln  Val Pro Arg Thr His  Arg Leu Ile 
    1940                 1945                 1950             


Thr Leu  Ala Asp His Ile Cys  Gln Ile Ile Thr Gln  Asp Phe Ala 
    1955                 1960                 1965             


Arg Asn  Gln Val Ser Ser Gln  Thr Pro Gln Gln Pro  Pro Thr Ser 
    1970                 1975                 1980             


Thr Phe  Gln Asn Ser Pro Ser  Ala Leu Val Ser Thr  Pro Val Arg 
    1985                 1990                 1995             


Thr Lys  Thr Ser Asn Arg Tyr  Ser Pro Glu Ser Gln  Ala Gln Ser 
    2000                 2005                 2010             


Val His  His Gln Arg Pro Gly  Ser Arg Val Ser Pro  Glu Asn Leu 
    2015                 2020                 2025             


Val Asp  Lys Ser Arg Gly Ser  Arg Pro Gly Lys Ser  Pro Glu Arg 
    2030                 2035                 2040             


Ser His  Val Ser Ser Glu Pro  Tyr Glu Pro Ile Ser  Pro Pro Gln 
    2045                 2050                 2055             


Val Pro  Val Val His Glu Lys  Gln Asp Ser Leu Leu  Leu Leu Ser 
    2060                 2065                 2070             


Gln Arg  Gly Ala Glu Pro Ala  Glu Gln Arg Asn Asp  Ala Arg Ser 
    2075                 2080                 2085             


Pro Gly  Ser Ile Ser Tyr Leu  Pro Ser Phe Phe Thr  Lys Leu Glu 
    2090                 2095                 2100             


Asn Thr  Ser Pro Met Val Lys  Ser Lys Lys Gln Glu  Ile Phe Arg 
    2105                 2110                 2115             


Lys Leu  Asn Ser Ser Gly Gly  Gly Asp Ser Asp Met  Ala Ala Ala 
    2120                 2125                 2130             


Gln Pro  Gly Thr Glu Ile Phe  Asn Leu Pro Ala Val  Thr Thr Ser 
    2135                 2140                 2145             


Gly Ser  Val Ser Ser Arg Gly  His Ser Phe Ala Asp  Pro Ala Ser 
    2150                 2155                 2160             


Asn Leu  Gly Leu Glu Asp Ile  Ile Arg Lys Ala Leu  Met Gly Ser 
    2165                 2170                 2175             


Phe Asp  Asp Lys Val Glu Asp  His Gly Val Val Met  Ser Gln Pro 
    2180                 2185                 2190             


Met Gly  Val Val Pro Gly Thr  Ala Asn Thr Ser Val  Val Thr Ser 
    2195                 2200                 2205             


Gly Glu  Thr Arg Arg Glu Glu  Gly Asp Pro Ser Pro  His Ser Gly 
    2210                 2215                 2220             


Val Cys  Lys Pro Lys Leu Ile  Ser Lys Ser Asn Ser  Arg Lys Ser 
    2225                 2230                 2235             


Lys Ser  Pro Ile Pro Gly Gln  Gly Tyr Leu Gly Thr  Glu Arg Pro 
    2240                 2245                 2250             


Ser Ser  Val Ser Ser Val His  Ser Glu Gly Asp Tyr  His Arg Gln 
    2255                 2260                 2265             


Thr Pro  Gly Trp Ala Trp Glu  Asp Arg Pro Ser Ser  Thr Gly Ser 
    2270                 2275                 2280             


Thr Gln  Phe Pro Tyr Asn Pro  Leu Thr Met Arg Met  Leu Ser Ser 
    2285                 2290                 2295             


Thr Pro  Pro Thr Pro Ile Ala  Cys Ala Pro Ser Ala  Val Asn Gln 
    2300                 2305                 2310             


Ala Ala  Pro His Gln Gln Asn  Arg Ile Trp Glu Arg  Glu Pro Ala 
    2315                 2320                 2325             


Pro Leu  Leu Ser Ala Gln Tyr  Glu Thr Leu Ser Asp  Ser Asp Asp 
    2330                 2335                 2340             


<210> 6930
<211> 2337
<212> PRT
<213> Homo sapiens

<400> 6930
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 
        35                  40                  45              


Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 
65                  70                  75                  80  


Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 
                85                  90                  95      


Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 
            100                 105                 110         


Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro 
        115                 120                 125             


Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys 
    130                 135                 140                 


Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile 
145                 150                 155                 160 


Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu 
                165                 170                 175     


Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile 
            180                 185                 190         


Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln 
        195                 200                 205             


Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser 
    210                 215                 220                 


Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr 
225                 230                 235                 240 


Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly 
                245                 250                 255     


Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr 
            260                 265                 270         


Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met Arg Lys Lys 
        275                 280                 285             


Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys Gln Arg Glu 
    290                 295                 300                 


Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala Trp Glu Lys 
305                 310                 315                 320 


Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala Lys Glu Ser 
                325                 330                 335     


Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile Arg Lys Gln 
            340                 345                 350         


Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg Gly Ala Gly 
        355                 360                 365             


Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser Glu Ile Ile 
    370                 375                 380                 


Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met Arg Gln Leu 
385                 390                 395                 400 


Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg Arg Val Lys 
                405                 410                 415     


Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys Val Tyr Lys 
            420                 425                 430         


Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys Glu Ile Phe 
        435                 440                 445             


Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu Ile Ala Ser 
    450                 455                 460                 


Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr Tyr Tyr Leu 
465                 470                 475                 480 


Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg Asn Tyr Gly 
                485                 490                 495     


Lys Arg Arg Gly Arg Asn Gln Gln Ile Ala Arg Pro Ser Gln Glu Glu 
            500                 505                 510         


Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr Glu Lys Lys 
        515                 520                 525             


Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys Glu Asp Ser 
    530                 535                 540                 


Lys Glu Asn Thr Lys Glu Lys Asp Lys Ile Asp Gly Thr Ala Glu Glu 
545                 550                 555                 560 


Thr Glu Glu Arg Glu Gln Ala Thr Pro Arg Gly Arg Lys Thr Ala Asn 
                565                 570                 575     


Ser Gln Gly Arg Arg Lys Gly Arg Ile Thr Arg Ser Met Thr Asn Glu 
            580                 585                 590         


Ala Ala Ala Ala Ser Ala Ala Ala Ala Ala Ala Thr Glu Glu Pro Pro 
        595                 600                 605             


Pro Pro Leu Pro Pro Pro Pro Glu Pro Ile Ser Thr Glu Pro Val Glu 
    610                 615                 620                 


Thr Ser Arg Trp Thr Glu Glu Glu Met Glu Val Ala Lys Lys Gly Leu 
625                 630                 635                 640 


Val Glu His Gly Arg Asn Trp Ala Ala Ile Ala Lys Met Val Gly Thr 
                645                 650                 655     


Lys Ser Glu Ala Gln Cys Lys Asn Phe Tyr Phe Asn Tyr Lys Arg Arg 
            660                 665                 670         


His Asn Leu Asp Asn Leu Leu Gln Gln His Lys Gln Lys Thr Ser Arg 
        675                 680                 685             


Lys Pro Arg Glu Glu Arg Asp Val Ser Gln Cys Glu Ser Val Ala Ser 
    690                 695                 700                 


Thr Val Ser Ala Gln Glu Asp Glu Asp Ile Glu Ala Ser Asn Glu Glu 
705                 710                 715                 720 


Glu Asn Pro Glu Asp Ser Glu Gly Ala Glu Asn Ser Ser Asp Thr Glu 
                725                 730                 735     


Ser Ala Pro Ser Pro Ser Pro Val Glu Ala Val Lys Pro Ser Glu Asp 
            740                 745                 750         


Ser Pro Glu Asn Ala Thr Ser Arg Gly Asn Thr Glu Pro Ala Val Glu 
        755                 760                 765             


Leu Glu Pro Thr Thr Glu Thr Ala Pro Ser Thr Ser Pro Ser Leu Ala 
    770                 775                 780                 


Val Pro Ser Thr Lys Pro Ala Glu Asp Glu Ser Val Glu Thr Gln Val 
785                 790                 795                 800 


Asn Asp Ser Ile Ser Ala Glu Thr Ala Glu Gln Met Asp Val Asp Gln 
                805                 810                 815     


Gln Glu His Ser Ala Glu Glu Gly Ser Val Cys Asp Pro Pro Pro Ala 
            820                 825                 830         


Thr Lys Ala Asp Ser Val Asp Val Glu Val Arg Val Pro Glu Asn His 
        835                 840                 845             


Ala Ser Lys Val Glu Gly Asp Asn Thr Lys Glu Arg Asp Leu Asp Arg 
    850                 855                 860                 


Ala Ser Glu Lys Val Glu Pro Arg Asp Glu Asp Leu Val Val Ala Gln 
865                 870                 875                 880 


Gln Ile Asn Ala Gln Arg Pro Glu Pro Gln Ser Asp Asn Asp Ser Ser 
                885                 890                 895     


Ala Thr Cys Ser Ala Asp Glu Asp Val Asp Gly Glu Pro Glu Arg Gln 
            900                 905                 910         


Arg Met Phe Pro Met Asp Ser Lys Pro Ser Leu Leu Asn Pro Thr Gly 
        915                 920                 925             


Ser Ile Leu Val Ser Ser Pro Leu Lys Pro Asn Pro Leu Asp Leu Pro 
    930                 935                 940                 


Gln Leu Gln His Arg Ala Ala Val Ile Pro Pro Met Val Ser Cys Thr 
945                 950                 955                 960 


Pro Cys Asn Ile Pro Ile Gly Thr Pro Val Ser Gly Tyr Ala Leu Tyr 
                965                 970                 975     


Gln Arg His Ile Lys Ala Met His Glu Ser Ala Leu Leu Glu Glu Gln 
            980                 985                 990         


Arg Gln Arg Gln Glu Gln Ile Asp  Leu Glu Cys Arg Ser  Ser Thr Ser 
        995                 1000                 1005             


Pro Cys  Gly Thr Ser Lys Ser  Pro Asn Arg Glu Trp  Glu Val Leu 
    1010                 1015                 1020             


Gln Pro  Ala Pro His Gln Val  Ile Thr Asn Leu Pro  Glu Gly Val 
    1025                 1030                 1035             


Arg Leu  Pro Thr Thr Arg Pro  Thr Arg Pro Pro Pro  Pro Leu Ile 
    1040                 1045                 1050             


Pro Ser  Ser Lys Thr Thr Val  Ala Ser Glu Lys Pro  Ser Phe Ile 
    1055                 1060                 1065             


Met Gly  Gly Ser Ile Ser Gln  Gly Thr Pro Gly Thr  Tyr Leu Thr 
    1070                 1075                 1080             


Ser His  Asn Gln Ala Ser Tyr  Thr Gln Glu Thr Pro  Lys Pro Ser 
    1085                 1090                 1095             


Val Gly  Ser Ile Ser Leu Gly  Leu Pro Arg Gln Gln  Glu Ser Ala 
    1100                 1105                 1110             


Lys Ser  Ala Thr Leu Pro Tyr  Ile Lys Gln Glu Glu  Phe Ser Pro 
    1115                 1120                 1125             


Arg Ser  Gln Asn Ser Gln Pro  Glu Gly Leu Leu Val  Arg Ala Gln 
    1130                 1135                 1140             


His Glu  Gly Val Val Arg Gly  Thr Ala Gly Ala Ile  Gln Glu Gly 
    1145                 1150                 1155             


Ser Ile  Thr Arg Gly Thr Pro  Thr Ser Lys Ile Ser  Val Glu Ser 
    1160                 1165                 1170             


Ile Pro  Ser Leu Arg Gly Ser  Ile Thr Gln Gly Thr  Pro Ala Leu 
    1175                 1180                 1185             


Pro Gln  Thr Gly Ile Pro Thr  Glu Ala Leu Val Lys  Gly Ser Ile 
    1190                 1195                 1200             


Ser Arg  Met Pro Ile Glu Asp  Ser Ser Pro Glu Lys  Gly Arg Glu 
    1205                 1210                 1215             


Glu Ala  Ala Ser Lys Gly His  Val Ile Tyr Glu Gly  Lys Ser Gly 
    1220                 1225                 1230             


His Ile  Leu Ser Tyr Asp Asn  Ile Lys Asn Ala Arg  Glu Gly Thr 
    1235                 1240                 1245             


Arg Ser  Pro Arg Thr Ala His  Glu Ile Ser Leu Lys  Arg Ser Tyr 
    1250                 1255                 1260             


Glu Ser  Val Glu Gly Asn Ile  Lys Gln Gly Met Ser  Met Arg Glu 
    1265                 1270                 1275             


Ser Pro  Val Ser Ala Pro Leu  Glu Gly Leu Ile Cys  Arg Ala Leu 
    1280                 1285                 1290             


Pro Arg  Gly Ser Pro His Ser  Asp Leu Lys Glu Arg  Thr Val Leu 
    1295                 1300                 1305             


Ser Gly  Ser Ile Met Gln Gly  Thr Pro Arg Ala Thr  Thr Glu Ser 
    1310                 1315                 1320             


Phe Glu  Asp Gly Leu Lys Tyr  Pro Lys Gln Ile Lys  Arg Glu Ser 
    1325                 1330                 1335             


Pro Pro  Ile Arg Ala Phe Glu  Gly Ala Ile Thr Lys  Gly Lys Pro 
    1340                 1345                 1350             


Tyr Asp  Gly Ile Thr Thr Ile  Lys Glu Met Gly Arg  Ser Ile His 
    1355                 1360                 1365             


Glu Ile  Pro Arg Gln Asp Ile  Leu Thr Gln Glu Ser  Arg Lys Thr 
    1370                 1375                 1380             


Pro Glu  Val Val Gln Ser Thr  Arg Pro Ile Ile Glu  Gly Ser Ile 
    1385                 1390                 1395             


Ser Gln  Gly Thr Pro Ile Lys  Phe Asp Asn Asn Ser  Gly Gln Ser 
    1400                 1405                 1410             


Ala Ile  Lys His Asn Val Lys  Ser Leu Ile Thr Gly  Pro Ser Lys 
    1415                 1420                 1425             


Leu Ser  Arg Gly Met Pro Pro  Leu Glu Ile Val Pro  Glu Asn Ile 
    1430                 1435                 1440             


Lys Val  Val Glu Arg Gly Lys  Tyr Glu Asp Val Lys  Ala Gly Glu 
    1445                 1450                 1455             


Thr Val  Arg Ser Arg His Thr  Ser Val Val Ser Ser  Gly Pro Ser 
    1460                 1465                 1470             


Val Leu  Arg Ser Thr Leu His  Glu Ala Pro Lys Ala  Gln Leu Ser 
    1475                 1480                 1485             


Pro Gly  Ile Tyr Asp Asp Thr  Ser Ala Arg Arg Thr  Pro Val Ser 
    1490                 1495                 1500             


Tyr Gln  Asn Thr Met Ser Arg  Gly Ser Pro Met Met  Asn Arg Thr 
    1505                 1510                 1515             


Ser Asp  Val Thr Ile Ser Ser  Asn Lys Ser Thr Asn  His Glu Arg 
    1520                 1525                 1530             


Lys Ser  Thr Leu Thr Pro Thr  Gln Arg Glu Ser Ile  Pro Ala Lys 
    1535                 1540                 1545             


Ser Pro  Val Pro Gly Val Asp  Pro Val Val Ser His  Ser Pro Phe 
    1550                 1555                 1560             


Asp Pro  His His Arg Gly Ser  Thr Ala Gly Glu Val  Tyr Arg Ser 
    1565                 1570                 1575             


His Leu  Pro Thr His Leu Asp  Pro Ala Met Pro Phe  His Arg Ala 
    1580                 1585                 1590             


Leu Asp  Pro Ala Ala Ala Ala  Tyr Leu Phe Gln Arg  Gln Leu Ser 
    1595                 1600                 1605             


Pro Thr  Pro Gly Tyr Pro Ser  Gln Tyr Gln Leu Tyr  Ala Met Glu 
    1610                 1615                 1620             


Asn Thr  Arg Gln Thr Ile Leu  Asn Asp Tyr Ile Thr  Ser Gln Gln 
    1625                 1630                 1635             


Met Gln  Val Asn Leu Arg Pro  Asp Val Ala Arg Gly  Leu Ser Pro 
    1640                 1645                 1650             


Arg Glu  Gln Pro Leu Gly Leu  Pro Tyr Pro Ala Thr  Arg Gly Ile 
    1655                 1660                 1665             


Ile Asp  Leu Thr Asn Met Pro  Pro Thr Ile Leu Val  Pro His Pro 
    1670                 1675                 1680             


Gly Gly  Thr Ser Thr Pro Pro  Met Asp Arg Ile Thr  Tyr Ile Pro 
    1685                 1690                 1695             


Gly Thr  Gln Ile Thr Phe Pro  Pro Arg Pro Tyr Asn  Ser Ala Ser 
    1700                 1705                 1710             


Met Ser  Pro Gly His Pro Thr  His Leu Ala Ala Ala  Ala Ser Ala 
    1715                 1720                 1725             


Glu Arg  Glu Arg Glu Arg Glu  Arg Glu Lys Glu Arg  Glu Arg Glu 
    1730                 1735                 1740             


Arg Ile  Ala Ala Ala Ser Ser  Asp Leu Tyr Leu Arg  Pro Gly Ser 
    1745                 1750                 1755             


Glu Gln  Pro Gly Arg Pro Gly  Ser His Gly Tyr Val  Arg Ser Pro 
    1760                 1765                 1770             


Ser Pro  Ser Val Arg Thr Gln  Glu Thr Met Leu Gln  Gln Arg Pro 
    1775                 1780                 1785             


Ser Val  Phe Gln Gly Thr Asn  Gly Thr Ser Val Ile  Thr Pro Leu 
    1790                 1795                 1800             


Asp Pro  Thr Ala Gln Leu Arg  Ile Met Pro Leu Pro  Ala Gly Gly 
    1805                 1810                 1815             


Pro Ser  Ile Ser Gln Gly Leu  Pro Ala Ser Arg Tyr  Asn Thr Ala 
    1820                 1825                 1830             


Ala Asp  Ala Leu Ala Ala Leu  Val Asp Ala Ala Ala  Ser Ala Pro 
    1835                 1840                 1845             


Gln Met  Asp Val Ser Lys Thr  Lys Glu Ile Ser Ser  His Arg Tyr 
    1850                 1855                 1860             


Glu Thr  Pro Ser Asp Ala Ile  Glu Val Ile Ser Pro  Ala Ser Ser 
    1865                 1870                 1875             


Pro Ala  Pro Pro Gln Glu Lys  Leu Gln Thr Tyr Gln  Pro Glu Val 
    1880                 1885                 1890             


Val Lys  Ala Asn Gln Ala Glu  Asn Asp Pro Thr Arg  Gln Tyr Glu 
    1895                 1900                 1905             


Gly Pro  Leu His His Tyr Arg  Pro Gln Gln Glu Ser  Pro Ser Pro 
    1910                 1915                 1920             


Gln Gln  Gln Leu Pro Pro Ser  Ser Gln Ala Glu Gly  Met Gly Gln 
    1925                 1930                 1935             


Val Pro  Arg Thr His Arg Leu  Ile Thr Leu Ala Asp  His Ile Cys 
    1940                 1945                 1950             


Gln Ile  Ile Thr Gln Asp Phe  Ala Arg Asn Gln Val  Ser Ser Gln 
    1955                 1960                 1965             


Thr Pro  Gln Gln Pro Pro Thr  Ser Thr Phe Gln Asn  Ser Pro Ser 
    1970                 1975                 1980             


Ala Leu  Val Ser Thr Pro Val  Arg Thr Lys Thr Ser  Asn Arg Tyr 
    1985                 1990                 1995             


Ser Pro  Glu Ser Gln Ala Gln  Ser Val His His Gln  Arg Pro Gly 
    2000                 2005                 2010             


Ser Arg  Val Ser Pro Glu Asn  Leu Val Asp Lys Ser  Arg Gly Ser 
    2015                 2020                 2025             


Arg Pro  Gly Lys Ser Pro Glu  Arg Ser His Val Ser  Ser Glu Pro 
    2030                 2035                 2040             


Tyr Glu  Pro Ile Ser Pro Pro  Gln Val Pro Val Val  His Glu Lys 
    2045                 2050                 2055             


Gln Asp  Ser Leu Leu Leu Leu  Ser Gln Arg Gly Ala  Glu Pro Ala 
    2060                 2065                 2070             


Glu Gln  Arg Asn Asp Ala Arg  Ser Pro Gly Ser Ile  Ser Tyr Leu 
    2075                 2080                 2085             


Pro Ser  Phe Phe Thr Lys Leu  Glu Asn Thr Ser Pro  Met Val Lys 
    2090                 2095                 2100             


Ser Lys  Lys Gln Glu Ile Phe  Arg Lys Leu Asn Ser  Ser Gly Gly 
    2105                 2110                 2115             


Gly Asp  Ser Asp Met Ala Ala  Ala Gln Pro Gly Thr  Glu Ile Phe 
    2120                 2125                 2130             


Asn Leu  Pro Ala Val Thr Thr  Ser Gly Ser Val Ser  Ser Arg Gly 
    2135                 2140                 2145             


His Ser  Phe Ala Asp Pro Ala  Ser Asn Leu Gly Leu  Glu Asp Ile 
    2150                 2155                 2160             


Ile Arg  Lys Ala Leu Met Gly  Ser Phe Asp Asp Lys  Val Glu Asp 
    2165                 2170                 2175             


His Gly  Val Val Met Ser Gln  Pro Met Gly Val Val  Pro Gly Thr 
    2180                 2185                 2190             


Ala Asn  Thr Ser Val Val Thr  Ser Gly Glu Thr Arg  Arg Glu Glu 
    2195                 2200                 2205             


Gly Asp  Pro Ser Pro His Ser  Gly Gly Val Cys Lys  Pro Lys Leu 
    2210                 2215                 2220             


Ile Ser  Lys Ser Asn Ser Arg  Lys Ser Lys Ser Pro  Ile Pro Gly 
    2225                 2230                 2235             


Gln Gly  Tyr Leu Gly Thr Glu  Arg Pro Ser Ser Val  Ser Ser Val 
    2240                 2245                 2250             


His Ser  Glu Gly Asp Tyr His  Arg Gln Thr Pro Gly  Trp Ala Trp 
    2255                 2260                 2265             


Glu Asp  Arg Pro Ser Ser Thr  Gly Ser Thr Gln Phe  Pro Tyr Asn 
    2270                 2275                 2280             


Pro Leu  Thr Met Arg Met Leu  Ser Ser Thr Pro Pro  Thr Pro Ile 
    2285                 2290                 2295             


Ala Cys  Ala Pro Ser Ala Val  Asn Gln Ala Ala Pro  His Gln Gln 
    2300                 2305                 2310             


Asn Arg  Ile Trp Glu Arg Glu  Pro Ala Pro Leu Leu  Ser Ala Gln 
    2315                 2320                 2325             


Tyr Glu  Thr Leu Ser Asp Ser  Asp Asp 
    2330                 2335         


<210> 6931
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 6931
Met Pro Pro Leu Glu Ile Val Pro Glu Asn Ile Lys Val Val Glu Arg 
1               5                   10                  15      


Gly Lys Tyr Glu Asp Val Lys Ala Gly Glu Thr Val Arg Ser Arg His 
            20                  25                  30          


Thr Ser Val Val Ser Ser Gly Pro Ser Val Leu Arg Ser Thr Leu His 
        35                  40                  45              


Glu Ala Pro Lys Ala Gln Leu Ser Pro Gly Ile Tyr Asp Asp Thr Ser 
    50                  55                  60                  


Ala Arg Arg Thr Pro Val Ser Tyr Gln Asn Thr Met Ser Arg Gly Ser 
65                  70                  75                  80  


Pro Met Met Asn Arg Thr Ser Asp Val Thr Ile Ser Ser Asn Lys Ser 
                85                  90                  95      


Thr Asn His Glu Arg Lys Ser Thr Leu Thr Pro Thr Gln Arg Glu Ser 
            100                 105                 110         


Ile Pro Ala Lys Ser Pro Val Pro Gly Val Asp Pro Val Val Ser His 
        115                 120                 125             


Ser Pro Phe Asp Pro His His Arg Gly Ser Thr Ala Gly Glu Val Tyr 
    130                 135                 140                 


Arg Ser His Leu Pro Thr His Leu Asp Pro Ala Met Pro Phe His Arg 
145                 150                 155                 160 


Ala Leu Asp Pro Ala Ala Ala Ala Tyr Leu Phe Gln Arg Gln Leu Ser 
                165                 170                 175     


Pro Thr Pro Gly Tyr Pro Ser Gln Tyr Gln Leu Tyr Ala Met Glu Asn 
            180                 185                 190         


Thr Arg Gln Thr Ile Leu Asn Asp Tyr Ile Thr Ser Gln Gln Met Gln 
        195                 200                 205             


Val Asn Leu Arg Pro Asp Val Ala Arg Gly Leu Ser Pro Arg Glu Gln 
    210                 215                 220                 


Pro Leu Gly Leu Pro Tyr Pro Ala Thr Arg Gly Ile Ile Asp Leu Thr 
225                 230                 235                 240 


Asn Met Pro Pro Thr Ile Leu Val Pro His Pro Gly Gly Thr Ser Thr 
                245                 250                 255     


Pro Pro Met Asp Arg Ile Thr Tyr Ile Pro Gly Thr Gln Ile Thr Phe 
            260                 265                 270         


Pro Pro Arg Pro Tyr Asn Ser Ala Ser Met Ser Pro Gly His Pro Thr 
        275                 280                 285             


His Leu Ala Ala Ala Ala Ser Ala Glu Arg Glu Arg Glu Arg Glu Arg 
    290                 295                 300                 


Glu Lys Glu Arg Glu Arg Glu Arg Ile Ala Ala Ala Ser Ser Asp Leu 
305                 310                 315                 320 


Tyr Leu Arg Pro Gly Ser Glu Gln Pro Gly Arg Pro Gly Ser His Gly 
                325                 330                 335     


Tyr Val Arg Ser Pro Ser Pro Ser Val Arg Thr Gln Glu Thr Met Leu 
            340                 345                 350         


Gln Gln Arg Pro Ser Val Phe Gln Gly Thr Asn Gly Thr Ser Val Ile 
        355                 360                 365             


Thr Pro Leu Asp Pro Thr Ala Gln Leu Arg Ile Met Pro Leu Pro Ala 
    370                 375                 380                 


Gly Gly Pro Ser Ile Ser Gln Gly Leu Pro Ala Ser Arg Tyr Asn Thr 
385                 390                 395                 400 


Ala Ala Asp Ala Leu Ala Ala Leu Val Asp Ala Ala Ala Ser Ala Pro 
                405                 410                 415     


Gln Met Asp Val Ser Lys Thr Lys Glu Ser Lys His Glu Ala Ala Arg 
            420                 425                 430         


Leu Glu Glu Asn Leu Arg Ser Arg Ser Ala Ala Val Ser Glu Gln Gln 
        435                 440                 445             


Gln Leu Glu Gln Lys Thr Leu Glu Val Glu Lys Arg Ser Val Gln Cys 
    450                 455                 460                 


Leu Tyr Thr Ser Ser Ala Phe Pro Ser Gly Lys Pro Gln Pro His Ser 
465                 470                 475                 480 


Ser Val Val Tyr Ser Glu Ala Gly Lys Asp Lys Gly Pro Pro Pro Lys 
                485                 490                 495     


Ser Arg Tyr Glu Glu Glu Leu Arg Thr Arg Gly Lys Thr Thr Ile Thr 
            500                 505                 510         


Ala Ala Asn Phe Ile Asp Val Ile Ile Thr Arg Gln Ile Ala Ser Asp 
        515                 520                 525             


Lys Asp Ala Arg Glu Arg Gly Ser Gln Ser Ser Asp Ser Ser Ser Ser 
    530                 535                 540                 


Leu Ser Ser His Arg Tyr Glu Thr Pro Ser Asp Ala Ile Glu Val Ile 
545                 550                 555                 560 


Ser Pro Ala Ser Ser Pro Ala Pro Pro Gln Glu Lys Leu Gln Thr Tyr 
                565                 570                 575     


Gln Pro Glu Val Val Lys Ala Asn Gln Ala Glu Asn Asp Pro Thr Arg 
            580                 585                 590         


Gln Tyr Glu Gly Pro Leu His His Tyr Arg Pro Gln Gln Glu Ser Pro 
        595                 600                 605             


Ser Pro Gln Gln Gln Leu Pro Pro Ser Ser Gln Ala Glu Gly Met Gly 
    610                 615                 620                 


Gln Val Pro Arg Thr His Arg Leu Ile Thr Leu Ala Asp His Ile Cys 
625                 630                 635                 640 


Gln Ile Ile Thr Gln Asp Phe Ala Arg Asn Gln Val Ser Ser Gln Thr 
                645                 650                 655     


Pro Gln Gln Pro Pro Thr Ser Thr Phe Gln Asn Ser Pro Ser Ala Leu 
            660                 665                 670         


Val Ser Thr Pro Val Arg Thr Lys Thr Ser Asn Arg Tyr Ser Pro Glu 
        675                 680                 685             


Ser Gln Ala Gln Ser Val His His Gln Arg Pro Gly Ser Arg Val Ser 
    690                 695                 700                 


Pro Glu Asn Leu Val Asp Lys Ser Arg Gly Ser Arg Pro Gly Lys Ser 
705                 710                 715                 720 


Pro Glu Arg Ser His Val Ser Ser Glu Pro Tyr Glu Pro Ile Ser Pro 
                725                 730                 735     


Pro Gln Val Pro Val Val His Glu Lys Gln Asp Ser Leu Leu Leu Leu 
            740                 745                 750         


Ser Gln Arg Gly Ala Glu Pro Ala Glu Gln Arg Asn Asp Ala Arg Ser 
        755                 760                 765             


Pro Gly Ser Ile Ser Tyr Leu Pro Ser Phe Phe Thr Lys Leu Glu Asn 
    770                 775                 780                 


Thr Ser Pro Met Val Lys Ser Lys Lys Gln Glu Ile Phe Arg Lys Leu 
785                 790                 795                 800 


Asn Ser Ser Gly Gly Gly Asp Ser Asp Met Ala Ala Ala Gln Pro Gly 
                805                 810                 815     


Thr Glu Ile Phe Asn Leu Pro Ala Val Thr Thr Ser Gly Ser Val Ser 
            820                 825                 830         


Ser Arg Gly His Ser Phe Ala Asp Pro Ala Ser Asn Leu Gly Leu Glu 
        835                 840                 845             


Asp Ile Ile Arg Lys Ala Leu Met Gly Ser Phe Asp Asp Lys Val Glu 
    850                 855                 860                 


Asp His Gly Val Val Met Ser Gln Pro Met Gly Val Val Pro Gly Thr 
865                 870                 875                 880 


Ala Asn Thr Ser Val Val Thr Ser Gly Glu Thr Arg Arg Glu Glu Gly 
                885                 890                 895     


Asp Pro Ser Pro His Ser Gly Gly Val Cys Lys Pro Lys Leu Ile Ser 
            900                 905                 910         


Lys Ser Asn Ser Arg Lys Ser Lys Ser Pro Ile Pro Gly Gln Gly Tyr 
        915                 920                 925             


Leu Gly Thr Glu Arg Pro Ser Ser Val Ser Ser Val His Ser Glu Gly 
    930                 935                 940                 


Asp Tyr His Arg Gln Thr Pro Gly Trp Ala Trp Glu Asp Arg Pro Ser 
945                 950                 955                 960 


Ser Thr Gly Ser Thr Gln Phe Pro Tyr Asn Pro Leu Thr Met Arg Met 
                965                 970                 975     


Leu Ser Ser Thr Pro Pro Thr Pro Ile Ala Cys Ala Pro Ser Ala Val 
            980                 985                 990         


Asn Gln Ala Ala Pro His Gln Gln  Asn Arg Ile Trp Glu  Arg Glu Pro 
        995                 1000                 1005             


Ala Pro  Leu Leu Ser Ala Gln  Tyr Glu Thr Leu Ser  Asp Ser Asp 
    1010                 1015                 1020             


Asp 
    


<210> 6932
<211> 1606
<212> PRT
<213> Homo sapiens

<400> 6932
Met Leu Leu His Leu Cys Ser Val Lys Asn Leu Tyr Gln Asn Arg Phe 
1               5                   10                  15      


Leu Gly Leu Ala Ala Met Ala Ser Pro Ser Arg Asn Ser Gln Ser Arg 
            20                  25                  30          


Arg Arg Cys Lys Glu Pro Leu Arg Tyr Ser Tyr Asn Pro Asp Gln Phe 
        35                  40                  45              


His Asn Met Asp Leu Arg Gly Gly Pro His Asp Gly Val Thr Ile Pro 
    50                  55                  60                  


Arg Ser Thr Ser Asp Thr Asp Leu Val Thr Ser Asp Ser Arg Ser Thr 
65                  70                  75                  80  


Leu Met Val Ser Ser Ser Tyr Tyr Ser Ile Gly His Ser Gln Asp Leu 
                85                  90                  95      


Val Ile His Trp Asp Ile Lys Glu Glu Val Asp Ala Gly Asp Trp Ile 
            100                 105                 110         


Gly Met Tyr Leu Ile Asp Glu Val Leu Ser Glu Asn Phe Leu Asp Tyr 
        115                 120                 125             


Lys Asn Arg Gly Val Asn Gly Ser His Arg Gly Gln Ile Ile Trp Lys 
    130                 135                 140                 


Ile Asp Ala Ser Ser Tyr Phe Val Glu Pro Glu Thr Lys Ile Cys Phe 
145                 150                 155                 160 


Lys Tyr Tyr His Gly Val Ser Gly Ala Leu Arg Ala Thr Thr Pro Ser 
                165                 170                 175     


Val Thr Val Lys Asn Ser Ala Ala Pro Ile Phe Lys Ser Ile Gly Ala 
            180                 185                 190         


Asp Glu Thr Val Gln Gly Gln Gly Ser Arg Arg Leu Ile Ser Phe Ser 
        195                 200                 205             


Leu Ser Asp Phe Gln Ala Met Gly Leu Lys Lys Gly Met Phe Phe Asn 
    210                 215                 220                 


Pro Asp Pro Tyr Leu Lys Ile Ser Ile Gln Pro Gly Lys His Ser Ile 
225                 230                 235                 240 


Phe Pro Ala Leu Pro His His Gly Gln Glu Arg Arg Ser Lys Ile Ile 
                245                 250                 255     


Gly Asn Thr Val Asn Pro Ile Trp Gln Ala Glu Gln Phe Ser Phe Val 
            260                 265                 270         


Ser Leu Pro Thr Asp Val Leu Glu Ile Glu Val Lys Asp Lys Phe Ala 
        275                 280                 285             


Lys Ser Arg Pro Ile Ile Lys Arg Phe Leu Gly Lys Leu Ser Met Pro 
    290                 295                 300                 


Val Gln Arg Leu Leu Glu Arg His Ala Ile Gly Asp Arg Val Val Ser 
305                 310                 315                 320 


Tyr Thr Leu Gly Arg Arg Leu Pro Thr Asp His Val Ser Gly Gln Leu 
                325                 330                 335     


Gln Phe Arg Phe Glu Ile Thr Ser Ser Ile His Pro Asp Asp Glu Glu 
            340                 345                 350         


Ile Ser Leu Ser Thr Glu Pro Glu Ser Ala Gln Ile Gln Asp Ser Pro 
        355                 360                 365             


Met Asn Asn Leu Met Glu Ser Gly Ser Gly Glu Pro Arg Ser Glu Ala 
    370                 375                 380                 


Pro Glu Ser Ser Glu Ser Trp Lys Pro Glu Gln Leu Gly Glu Gly Ser 
385                 390                 395                 400 


Val Pro Asp Gly Pro Gly Asn Gln Ser Ile Glu Leu Ser Arg Pro Ala 
                405                 410                 415     


Glu Glu Ala Ala Val Ile Thr Glu Ala Gly Asp Gln Gly Met Val Ser 
            420                 425                 430         


Val Gly Pro Glu Gly Ala Gly Glu Leu Leu Ala Gln Val Gln Lys Asp 
        435                 440                 445             


Ile Gln Pro Ala Pro Ser Ala Glu Glu Leu Ala Glu Gln Leu Asp Leu 
    450                 455                 460                 


Gly Glu Glu Ala Ser Ala Leu Leu Leu Glu Asp Gly Glu Ala Pro Ala 
465                 470                 475                 480 


Ser Thr Lys Glu Glu Pro Leu Glu Glu Glu Ala Thr Thr Gln Ser Arg 
                485                 490                 495     


Ala Gly Arg Glu Glu Glu Glu Lys Glu Gln Glu Glu Glu Gly Asp Val 
            500                 505                 510         


Ser Thr Leu Glu Gln Gly Glu Gly Arg Leu Gln Leu Arg Ala Ser Val 
        515                 520                 525             


Lys Arg Lys Ser Arg Pro Cys Ser Leu Pro Val Ser Glu Leu Glu Thr 
    530                 535                 540                 


Val Ile Ala Ser Ala Cys Gly Asp Pro Glu Thr Pro Arg Thr His Tyr 
545                 550                 555                 560 


Ile Arg Ile His Thr Leu Leu His Ser Met Pro Ser Ala Gln Gly Gly 
                565                 570                 575     


Ser Ala Ala Glu Glu Glu Asp Gly Ala Glu Glu Glu Ser Thr Leu Lys 
            580                 585                 590         


Asp Ser Ser Glu Lys Asp Gly Leu Ser Glu Val Asp Thr Val Ala Ala 
        595                 600                 605             


Asp Pro Ser Ala Leu Glu Glu Asp Arg Glu Glu Pro Glu Gly Ala Thr 
    610                 615                 620                 


Pro Gly Thr Ala His Pro Gly His Ser Gly Gly His Phe Pro Ser Leu 
625                 630                 635                 640 


Ala Asn Gly Ala Ala Gln Asp Gly Asp Thr His Pro Ser Thr Gly Ser 
                645                 650                 655     


Glu Ser Asp Ser Ser Pro Arg Gln Gly Gly Asp His Ser Cys Glu Gly 
            660                 665                 670         


Cys Asp Ala Ser Cys Cys Ser Pro Ser Cys Tyr Ser Ser Ser Cys Tyr 
        675                 680                 685             


Ser Thr Ser Cys Tyr Ser Ser Ser Cys Tyr Ser Ala Ser Cys Tyr Ser 
    690                 695                 700                 


Pro Ser Cys Tyr Asn Gly Asn Arg Phe Ala Ser His Thr Arg Phe Ser 
705                 710                 715                 720 


Ser Val Asp Ser Ala Lys Ile Ser Glu Ser Thr Val Phe Ser Ser Gln 
                725                 730                 735     


Asp Asp Glu Glu Glu Glu Asn Ser Ala Phe Glu Ser Val Pro Asp Ser 
            740                 745                 750         


Met Gln Ser Pro Glu Leu Asp Pro Glu Ser Thr Asn Gly Ala Gly Pro 
        755                 760                 765             


Trp Gln Asp Glu Leu Ala Ala Pro Ser Gly His Val Glu Arg Ser Pro 
    770                 775                 780                 


Glu Gly Leu Glu Ser Pro Val Ala Gly Pro Ser Asn Arg Arg Glu Gly 
785                 790                 795                 800 


Glu Cys Pro Ile Leu His Asn Ser Gln Pro Val Ser Gln Leu Pro Ser 
                805                 810                 815     


Leu Arg Pro Glu His His His Tyr Pro Thr Ile Asp Glu Pro Leu Pro 
            820                 825                 830         


Pro Asn Trp Glu Ala Arg Ile Asp Ser His Gly Arg Val Phe Tyr Val 
        835                 840                 845             


Asp His Val Asn Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Ala Ala 
    850                 855                 860                 


Thr Pro Asp Gly Met Arg Arg Ser Gly Ser Ile Gln Gln Met Glu Gln 
865                 870                 875                 880 


Leu Asn Arg Arg Tyr Gln Asn Ile Gln Arg Thr Ile Ala Thr Glu Arg 
                885                 890                 895     


Ser Glu Glu Asp Ser Gly Ser Gln Ser Cys Glu Gln Ala Pro Ala Gly 
            900                 905                 910         


Gly Gly Gly Gly Gly Gly Ser Asp Ser Glu Ala Glu Ser Ser Gln Ser 
        915                 920                 925             


Ser Leu Asp Leu Arg Arg Glu Gly Ser Leu Ser Pro Val Asn Ser Gln 
    930                 935                 940                 


Lys Ile Thr Leu Leu Leu Gln Ser Pro Ala Val Lys Phe Ile Thr Asn 
945                 950                 955                 960 


Pro Glu Phe Phe Thr Val Leu His Ala Asn Tyr Ser Ala Tyr Arg Val 
                965                 970                 975     


Phe Thr Ser Ser Thr Cys Leu Lys His Met Ile Leu Lys Val Arg Arg 
            980                 985                 990         


Asp Ala Arg Asn Phe Glu Arg Tyr  Gln His Asn Arg Asp  Leu Val Asn 
        995                 1000                 1005             


Phe Ile  Asn Met Phe Ala Asp  Thr Arg Leu Glu Leu  Pro Arg Gly 
    1010                 1015                 1020             


Trp Glu  Ile Lys Thr Asp Gln  Gln Gly Lys Ser Phe  Phe Val Asp 
    1025                 1030                 1035             


His Asn  Ser Arg Ala Thr Thr  Phe Ile Asp Pro Arg  Ile Pro Leu 
    1040                 1045                 1050             


Gln Asn  Gly Arg Leu Pro Asn  His Leu Thr His Arg  Gln His Leu 
    1055                 1060                 1065             


Gln Arg  Leu Arg Ser Tyr Ser  Ala Gly Glu Ala Ser  Glu Val Ser 
    1070                 1075                 1080             


Arg Asn  Arg Gly Ala Ser Leu  Leu Ala Arg Pro Gly  His Ser Leu 
    1085                 1090                 1095             


Val Ala  Ala Ile Arg Ser Gln  His Gln His Glu Ser  Leu Pro Leu 
    1100                 1105                 1110             


Ala Tyr  Asn Asp Lys Ile Val  Ala Phe Leu Arg Gln  Pro Asn Ile 
    1115                 1120                 1125             


Phe Glu  Met Leu Gln Glu Arg  Gln Pro Ser Leu Ala  Arg Asn His 
    1130                 1135                 1140             


Thr Leu  Arg Glu Lys Ile His  Tyr Ile Arg Thr Glu  Gly Asn His 
    1145                 1150                 1155             


Gly Leu  Glu Lys Leu Ser Cys  Asp Ala Asp Leu Val  Ile Leu Leu 
    1160                 1165                 1170             


Ser Leu  Phe Glu Glu Glu Ile  Met Ser Tyr Val Pro  Leu Gln Ala 
    1175                 1180                 1185             


Ala Phe  His Pro Gly Tyr Ser  Phe Ser Pro Arg Cys  Ser Pro Cys 
    1190                 1195                 1200             


Ser Ser  Pro Gln Asn Ser Pro  Gly Leu Gln Arg Ala  Ser Ala Arg 
    1205                 1210                 1215             


Ala Pro  Ser Pro Tyr Arg Arg  Asp Phe Glu Ala Lys  Leu Arg Asn 
    1220                 1225                 1230             


Phe Tyr  Arg Lys Leu Glu Ala  Lys Gly Phe Gly Gln  Gly Pro Gly 
    1235                 1240                 1245             


Lys Ile  Lys Leu Ile Ile Arg  Arg Asp His Leu Leu  Glu Gly Thr 
    1250                 1255                 1260             


Phe Asn  Gln Val Met Ala Tyr  Ser Arg Lys Glu Leu  Gln Arg Asn 
    1265                 1270                 1275             


Lys Leu  Tyr Val Thr Phe Val  Gly Glu Glu Gly Leu  Asp Tyr Ser 
    1280                 1285                 1290             


Gly Pro  Ser Arg Glu Phe Phe  Phe Leu Leu Ser Gln  Glu Leu Phe 
    1295                 1300                 1305             


Asn Pro  Tyr Tyr Gly Leu Phe  Glu Tyr Ser Ala Asn  Asp Thr Tyr 
    1310                 1315                 1320             


Thr Val  Gln Ile Ser Pro Met  Ser Ala Phe Val Glu  Asn His Leu 
    1325                 1330                 1335             


Glu Trp  Phe Arg Phe Ser Gly  Arg Ile Leu Gly Leu  Ala Leu Ile 
    1340                 1345                 1350             


His Gln  Tyr Leu Leu Asp Ala  Phe Phe Thr Arg Pro  Phe Tyr Lys 
    1355                 1360                 1365             


Ala Leu  Leu Arg Leu Pro Cys  Asp Leu Ser Asp Leu  Glu Tyr Leu 
    1370                 1375                 1380             


Asp Glu  Glu Phe His Gln Ser  Leu Gln Trp Met Lys  Asp Asn Asn 
    1385                 1390                 1395             


Ile Thr  Asp Ile Leu Asp Leu  Thr Phe Thr Val Asn  Glu Glu Val 
    1400                 1405                 1410             


Phe Gly  Gln Val Thr Glu Arg  Glu Leu Lys Ser Gly  Gly Ala Asn 
    1415                 1420                 1425             


Thr Gln  Val Thr Glu Lys Asn  Lys Lys Glu Tyr Ile  Glu Arg Met 
    1430                 1435                 1440             


Val Lys  Trp Arg Val Glu Arg  Gly Val Val Gln Gln  Thr Glu Ala 
    1445                 1450                 1455             


Leu Val  Arg Gly Phe Tyr Glu  Val Val Asp Ser Arg  Leu Val Ser 
    1460                 1465                 1470             


Val Phe  Asp Ala Arg Glu Leu  Glu Leu Val Ile Ala  Gly Thr Ala 
    1475                 1480                 1485             


Glu Ile  Asp Leu Asn Asp Trp  Arg Asn Asn Thr Glu  Tyr Arg Gly 
    1490                 1495                 1500             


Gly Tyr  His Asp Gly His Leu  Val Ile Arg Trp Phe  Trp Ala Ala 
    1505                 1510                 1515             


Val Glu  Arg Phe Asn Asn Glu  Gln Arg Leu Arg Leu  Leu Gln Phe 
    1520                 1525                 1530             


Val Thr  Gly Thr Ser Ser Val  Pro Tyr Glu Gly Phe  Ala Ala Leu 
    1535                 1540                 1545             


Arg Gly  Ser Asn Gly Leu Arg  Arg Phe Cys Ile Glu  Lys Trp Gly 
    1550                 1555                 1560             


Lys Ile  Thr Ser Leu Pro Arg  Ala His Thr Cys Phe  Asn Arg Leu 
    1565                 1570                 1575             


Asp Leu  Pro Pro Tyr Pro Ser  Tyr Ser Met Leu Tyr  Glu Lys Leu 
    1580                 1585                 1590             


Leu Thr  Ala Val Glu Glu Thr  Ser Thr Phe Gly Leu  Glu 
    1595                 1600                 1605     


<210> 6933
<211> 402
<212> PRT
<213> Homo sapiens

<400> 6933
Met Ala Ala Leu Cys Arg Thr Ala Glu Ser Gln Ala Glu Leu Gln Cys 
1               5                   10                  15      


Thr Gln Leu Asp Leu Glu Arg Lys Leu Lys Leu Asn Glu Asn Ala Ile 
            20                  25                  30          


Ser Arg Leu Gln Ala Asn Gln Lys Ser Val Leu Val Ser Val Ser Glu 
        35                  40                  45              


Val Lys Ala Val Ala Glu Met Gln Phe Gly Glu Leu Leu Ala Ala Val 
    50                  55                  60                  


Arg Lys Ala Gln Ala Asn Val Met Leu Phe Leu Glu Glu Lys Glu Gln 
65                  70                  75                  80  


Ala Ala Leu Ser Gln Ala Asn Gly Ile Lys Ala His Leu Glu Tyr Arg 
                85                  90                  95      


Ser Ala Glu Met Glu Lys Ser Lys Gln Glu Leu Glu Thr Met Ala Ala 
            100                 105                 110         


Ile Ser Asn Thr Val Gln Phe Leu Glu Glu Tyr Cys Lys Phe Lys Asn 
        115                 120                 125             


Thr Glu Asp Ile Thr Phe Pro Ser Val Tyr Ile Gly Leu Lys Asp Lys 
    130                 135                 140                 


Leu Ser Gly Ile Arg Lys Val Ile Thr Glu Ser Thr Val His Leu Ile 
145                 150                 155                 160 


Gln Leu Leu Glu Asn Tyr Lys Lys Lys Leu Gln Glu Phe Ser Lys Glu 
                165                 170                 175     


Glu Glu Tyr Asp Ile Arg Thr Gln Val Ser Ala Ile Val Gln Arg Lys 
            180                 185                 190         


Tyr Trp Thr Ser Lys Pro Glu Pro Ser Thr Arg Glu Gln Phe Leu Gln 
        195                 200                 205             


Tyr Val His Asp Ile Thr Phe Asp Pro Asp Thr Ala His Lys Tyr Leu 
    210                 215                 220                 


Arg Leu Gln Glu Glu Asn Arg Lys Val Thr Asn Thr Thr Pro Trp Glu 
225                 230                 235                 240 


His Pro Tyr Pro Asp Leu Pro Ser Arg Phe Leu His Trp Arg Gln Val 
                245                 250                 255     


Leu Ser Gln Gln Ser Leu Tyr Leu His Arg Tyr Tyr Phe Glu Val Glu 
            260                 265                 270         


Ile Phe Gly Ala Gly Thr Tyr Val Gly Leu Thr Cys Lys Gly Ile Asp 
        275                 280                 285             


Gln Lys Gly Glu Glu Arg Ser Ser Cys Ile Ser Gly Asn Asn Phe Ser 
    290                 295                 300                 


Trp Ser Leu Gln Trp Asn Gly Lys Glu Phe Thr Ala Trp Tyr Ser Asp 
305                 310                 315                 320 


Met Glu Thr Pro Leu Lys Ala Gly Pro Phe Trp Arg Leu Gly Val Tyr 
                325                 330                 335     


Ile Asp Phe Pro Gly Gly Ile Leu Ser Phe Tyr Gly Val Glu Tyr Asp 
            340                 345                 350         


Ser Met Thr Leu Val His Lys Phe Ala Cys Lys Phe Ser Glu Pro Val 
        355                 360                 365             


Tyr Ala Ala Phe Trp Leu Ser Lys Lys Glu Asn Ala Ile Arg Ile Val 
    370                 375                 380                 


Asp Leu Gly Glu Glu Pro Glu Lys Pro Ala Pro Ser Leu Val Gly Thr 
385                 390                 395                 400 


Ala Pro 
        


<210> 6934
<211> 558
<212> PRT
<213> Homo sapiens

<400> 6934
Met His Arg Ser Ala Pro Ser Gln Thr Thr Lys Arg Ser Arg Ser Pro 
1               5                   10                  15      


Phe Ser Thr Thr Arg Arg Ser Trp Asp Asp Ser Glu Ser Ser Gly Thr 
            20                  25                  30          


Asn Leu Asn Ile Asp Asn Glu Asp Tyr Ser Arg Tyr Pro Pro Arg Glu 
        35                  40                  45              


Tyr Arg Ala Ser Gly Ser Arg Arg Gly Met Ala Tyr Gly His Ile Asp 
    50                  55                  60                  


Ser Tyr Gly Ala Asp Asp Ser Glu Glu Glu Gly Ala Gly Pro Val Glu 
65                  70                  75                  80  


Arg Pro Pro Val Arg Gly Lys Thr Gly Lys Phe Lys Asp Asp Lys Leu 
                85                  90                  95      


Leu Asp Pro Val Pro Ala Ala Arg Cys Ser Ala Ser Arg Ala Asp Phe 
            100                 105                 110         


Leu Pro Gln Ser Ser Val Ala Ser Gln Ser Ser Ser Glu Gly Lys Leu 
        115                 120                 125             


Ala Thr Lys Gly Asp Ser Ser Glu Arg Glu Arg Arg Glu Gln Asn Leu 
    130                 135                 140                 


Pro Ala Arg Pro Ser Arg Ala Pro Val Ser Ile Cys Gly Gly Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Lys Ser Ala Glu Glu Pro Val Val Arg Pro Lys Ile Arg 
                165                 170                 175     


Asn Leu Ala Ser Pro Asn Cys Val Lys Pro Lys Ile Phe Phe Asp Thr 
            180                 185                 190         


Asp Asp Asp Asp Asp Met Pro His Ser Thr Ser Arg Trp Arg Asp Thr 
        195                 200                 205             


Ala Asn Asp Asn Glu Gly His Ser Asp Gly Leu Ala Arg Arg Gly Arg 
    210                 215                 220                 


Gly Glu Ser Ser Ser Gly Tyr Pro Glu Pro Lys Tyr Pro Glu Asp Lys 
225                 230                 235                 240 


Arg Glu Ala Arg Ser Asp Gln Val Lys Pro Glu Lys Val Pro Arg Arg 
                245                 250                 255     


Arg Arg Thr Met Ala Asp Pro Asp Phe Trp Thr His Ser Asp Asp Tyr 
            260                 265                 270         


Tyr Lys Tyr Cys Asp Glu Asp Ser Asp Ser Asp Lys Glu Trp Ile Ala 
        275                 280                 285             


Ala Leu Arg Arg Lys Tyr Arg Ser Arg Glu Gln Thr Leu Ser Ser Ser 
    290                 295                 300                 


Gly Glu Ser Trp Glu Thr Leu Pro Gly Lys Glu Glu Arg Glu Pro Pro 
305                 310                 315                 320 


Gln Ala Lys Val Ser Ala Ser Thr Gly Thr Ser Pro Gly Pro Gly Ala 
                325                 330                 335     


Ser Ala Ser Ala Gly Ala Gly Ala Gly Ala Ser Ala Gly Ser Asn Gly 
            340                 345                 350         


Ser Asn Tyr Leu Glu Glu Val Arg Glu Pro Ser Leu Gln Glu Glu Gln 
        355                 360                 365             


Ala Ser Leu Glu Glu Gly Glu Ile Pro Trp Leu Gln Tyr His Glu Asn 
    370                 375                 380                 


Asp Ser Ser Ser Glu Gly Asp Asn Asp Ser Gly His Glu Leu Met Gln 
385                 390                 395                 400 


Pro Gly Val Phe Met Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser 
                405                 410                 415     


Ser Val Ser Glu Asp Leu Glu Val Asp Trp Ser Leu Phe Asp Gly Phe 
            420                 425                 430         


Ala Asp Gly Leu Gly Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln 
        435                 440                 445             


Phe Leu Thr Tyr Met Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu 
    450                 455                 460                 


Thr Ala Leu Ala His Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala 
465                 470                 475                 480 


Asn Pro Pro Ala Ser Lys Glu Ser Ile Asp Ala Leu Pro Glu Ile Leu 
                485                 490                 495     


Val Thr Glu Asp His Gly Ala Val Gly Gln Glu Met Cys Cys Pro Ile 
            500                 505                 510         


Cys Cys Ser Glu Tyr Val Lys Gly Glu Val Ala Thr Glu Leu Pro Cys 
        515                 520                 525             


His His Tyr Phe His Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser 
    530                 535                 540                 


Gly Thr Cys Pro Val Cys Arg Cys Met Phe Pro Pro Pro Leu 
545                 550                 555             


<210> 6935
<211> 1196
<212> PRT
<213> Homo sapiens

<400> 6935
Val Pro Pro Cys Pro Ala Glu Leu Arg Ser Val Thr Asn Gly Gln Ser 
1               5                   10                  15      


Asn Gln Pro Ser Asn Glu Gly Asp Ala Ile Lys Val Phe Val Arg Ile 
            20                  25                  30          


Arg Pro Pro Ala Glu Arg Ser Gly Ser Ala Asp Gly Glu Gln Asn Leu 
        35                  40                  45              


Cys Leu Ser Val Leu Ser Ser Thr Ser Leu Arg Leu His Ser Asn Pro 
    50                  55                  60                  


Glu Pro Lys Thr Phe Thr Phe Asp His Val Ala Asp Val Asp Thr Thr 
65                  70                  75                  80  


Gln Glu Ser Val Phe Ala Thr Val Ala Lys Ser Ile Val Glu Ser Cys 
                85                  90                  95      


Met Ser Gly Tyr Asn Gly Thr Ile Phe Ala Tyr Gly Gln Thr Gly Ser 
            100                 105                 110         


Gly Lys Thr Phe Thr Met Met Gly Pro Ser Glu Ser Asp Asn Phe Ser 
        115                 120                 125             


His Asn Leu Arg Gly Val Ile Pro Arg Ser Phe Glu Tyr Leu Phe Ser 
    130                 135                 140                 


Leu Ile Asp Arg Glu Lys Glu Lys Ala Gly Ala Gly Lys Ser Phe Leu 
145                 150                 155                 160 


Cys Lys Cys Ser Phe Ile Glu Ile Tyr Asn Glu Gln Ile Tyr Asp Leu 
                165                 170                 175     


Leu Asp Ser Ala Ser Ala Gly Leu Tyr Leu Arg Glu His Ile Lys Lys 
            180                 185                 190         


Gly Val Phe Val Val Gly Ala Val Glu Gln Val Val Thr Ser Ala Ala 
        195                 200                 205             


Glu Ala Tyr Gln Val Leu Ser Gly Gly Trp Arg Asn Arg Arg Val Ala 
    210                 215                 220                 


Ser Thr Ser Met Asn Arg Glu Ser Ser Arg Ser His Ala Val Phe Thr 
225                 230                 235                 240 


Ile Thr Ile Glu Ser Met Glu Lys Ser Asn Glu Ile Val Asn Ile Arg 
                245                 250                 255     


Thr Ser Leu Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln Lys 
            260                 265                 270         


Asp Thr His Ala Glu Gly Met Arg Leu Lys Glu Ala Gly Asn Ile Asn 
        275                 280                 285             


Arg Ser Leu Ser Cys Leu Gly Gln Val Ile Thr Ala Leu Val Asp Val 
    290                 295                 300                 


Gly Asn Gly Lys Gln Arg His Val Cys Tyr Arg Asp Ser Lys Leu Thr 
305                 310                 315                 320 


Phe Leu Leu Arg Asp Ser Leu Gly Gly Asn Ala Lys Thr Ala Ile Ile 
                325                 330                 335     


Ala Asn Val His Pro Gly Ser Arg Cys Phe Gly Glu Thr Leu Ser Thr 
            340                 345                 350         


Leu Asn Phe Ala Gln Arg Ala Lys Leu Ile Lys Asn Lys Ala Val Val 
        355                 360                 365             


Asn Glu Asp Thr Gln Gly Asn Val Ser Gln Leu Gln Ala Glu Val Lys 
    370                 375                 380                 


Arg Leu Lys Glu Gln Leu Ala Glu Leu Ala Ser Gly Gln Thr Pro Pro 
385                 390                 395                 400 


Glu Ser Phe Leu Thr Arg Asp Lys Lys Lys Thr Asn Tyr Met Glu Tyr 
                405                 410                 415     


Phe Gln Glu Ala Met Leu Phe Phe Lys Lys Ser Glu Gln Glu Lys Lys 
            420                 425                 430         


Ser Leu Ile Glu Lys Val Thr Gln Leu Glu Asp Leu Thr Leu Lys Lys 
        435                 440                 445             


Glu Lys Phe Ile Gln Ser Asn Lys Met Ile Val Lys Phe Arg Glu Asp 
    450                 455                 460                 


Gln Ile Ile Arg Leu Glu Lys Leu His Lys Glu Ser Arg Gly Gly Phe 
465                 470                 475                 480 


Leu Pro Glu Glu Gln Asp Arg Leu Leu Ser Glu Leu Arg Asn Glu Ile 
                485                 490                 495     


Gln Thr Leu Arg Glu Gln Ile Glu His His Pro Arg Val Ala Lys Tyr 
            500                 505                 510         


Ala Met Glu Asn His Ser Leu Arg Glu Glu Asn Arg Arg Leu Arg Leu 
        515                 520                 525             


Leu Glu Pro Val Lys Arg Ala Gln Glu Met Asp Ala Gln Thr Ile Ala 
    530                 535                 540                 


Lys Leu Glu Lys Ala Phe Ser Glu Ile Ser Gly Met Glu Lys Ser Asp 
545                 550                 555                 560 


Lys Asn Gln Gln Gly Phe Ser Pro Lys Ala Gln Lys Glu Pro Cys Leu 
                565                 570                 575     


Phe Ala Asn Thr Glu Lys Leu Lys Ala Gln Leu Leu Gln Ile Gln Thr 
            580                 585                 590         


Glu Leu Asn Asn Ser Lys Gln Glu Tyr Glu Glu Phe Lys Glu Leu Thr 
        595                 600                 605             


Arg Lys Arg Gln Leu Glu Leu Glu Ser Glu Leu Gln Ser Leu Gln Lys 
    610                 615                 620                 


Ala Asn Leu Asn Leu Glu Asn Leu Leu Glu Ala Thr Lys Ala Cys Lys 
625                 630                 635                 640 


Arg Gln Glu Val Ser Gln Leu Asn Lys Ile His Ala Glu Thr Leu Lys 
                645                 650                 655     


Ile Ile Thr Thr Pro Thr Lys Ala Tyr Gln Leu His Ser Arg Pro Val 
            660                 665                 670         


Pro Lys Leu Ser Pro Glu Met Gly Ser Phe Gly Ser Leu Tyr Thr Gln 
        675                 680                 685             


Asn Ser Ser Ile Leu Asp Asn Asp Ile Leu Asn Glu Pro Val Pro Pro 
    690                 695                 700                 


Glu Met Asn Glu Gln Ala Phe Glu Ala Ile Ser Glu Glu Leu Arg Thr 
705                 710                 715                 720 


Val Gln Glu Gln Met Ser Ala Leu Gln Ala Lys Leu Asp Glu Glu Glu 
                725                 730                 735     


His Lys Asn Leu Lys Leu Gln Gln His Val Asp Lys Leu Glu His His 
            740                 745                 750         


Ser Thr Gln Met Gln Glu Leu Phe Ser Ser Glu Arg Ile Asp Trp Thr 
        755                 760                 765             


Lys Gln Gln Glu Glu Leu Leu Ser Gln Leu Asn Val Leu Glu Lys Gln 
    770                 775                 780                 


Leu Gln Glu Thr Gln Thr Lys Asn Asp Phe Leu Lys Ser Glu Val His 
785                 790                 795                 800 


Asp Leu Arg Val Val Leu His Ser Ala Asp Lys Glu Leu Ser Ser Val 
                805                 810                 815     


Lys Leu Glu Tyr Ser Ser Phe Lys Thr Asn Gln Glu Lys Glu Phe Asn 
            820                 825                 830         


Lys Leu Ser Glu Arg His Met His Val Gln Leu Gln Leu Asp Asn Leu 
        835                 840                 845             


Arg Leu Glu Asn Glu Lys Leu Leu Glu Ser Lys Ala Cys Leu Gln Asp 
    850                 855                 860                 


Ser Tyr Asp Asn Leu Gln Glu Ile Met Lys Phe Glu Ile Asp Gln Leu 
865                 870                 875                 880 


Ser Arg Asn Leu Gln Asn Phe Lys Lys Glu Asn Glu Thr Leu Lys Ser 
                885                 890                 895     


Asp Leu Asn Asn Leu Met Glu Leu Leu Glu Ala Glu Lys Glu Arg Asn 
            900                 905                 910         


Asn Lys Leu Ser Leu Gln Phe Glu Glu Asp Lys Glu Asn Ser Ser Lys 
        915                 920                 925             


Glu Ile Leu Lys Val Leu Glu Ala Val Arg Gln Glu Lys Gln Lys Glu 
    930                 935                 940                 


Thr Ala Lys Cys Glu Gln Gln Met Ala Lys Val Gln Lys Leu Glu Glu 
945                 950                 955                 960 


Ser Leu Leu Ala Thr Glu Lys Val Ile Ser Ser Leu Glu Lys Ser Arg 
                965                 970                 975     


Asp Ser Asp Lys Lys Val Val Ala Asp Leu Met Asn Gln Ile Gln Glu 
            980                 985                 990         


Leu Arg Thr Ser Val Cys Glu Lys  Thr Glu Thr Ile Asp  Thr Leu Lys 
        995                 1000                 1005             


Gln Glu  Leu Lys Asp Ile Asn  Cys Lys Tyr Asn Ser  Ala Leu Val 
    1010                 1015                 1020             


Asp Arg  Glu Glu Ser Arg Val  Leu Ile Lys Lys Gln  Glu Val Asp 
    1025                 1030                 1035             


Ile Leu  Asp Leu Lys Glu Thr  Leu Arg Leu Arg Ile  Leu Ser Glu 
    1040                 1045                 1050             


Asp Ile  Glu Arg Asp Met Leu  Cys Glu Asp Leu Ala  His Ala Thr 
    1055                 1060                 1065             


Glu Gln  Leu Asn Met Leu Thr  Glu Ala Ser Lys Lys  His Ser Gly 
    1070                 1075                 1080             


Leu Leu  Gln Ser Ala Gln Arg  Thr Asp Gln Glu Gly  Ser Pro Asp 
    1085                 1090                 1095             


Ser Gly  Thr Ser Ala Gln Ala  Lys Pro Lys Glu Arg  Gly Ser Arg 
    1100                 1105                 1110             


Thr Glu  Glu Glu Tyr Asn Phe  Lys Met Arg Gln Leu  Glu His Val 
    1115                 1120                 1125             


Met Asp  Ser Ala Ala Glu Asp  Pro Gln Ser Pro Lys  Thr Pro Pro 
    1130                 1135                 1140             


His Phe  Gln Thr His Leu Ala  Lys Leu Leu Glu Thr  Gln Glu Gln 
    1145                 1150                 1155             


Glu Ile  Glu Asp Gly Arg Ala  Ser Lys Thr Ser Leu  Glu His Leu 
    1160                 1165                 1170             


Val Thr  Lys Leu Asn Glu Asp  Arg Glu Val Lys Asn  Ala Glu Ile 
    1175                 1180                 1185             


Leu Arg  Met Lys Glu Gln Leu  Arg 
    1190                 1195     


<210> 6936
<211> 1087
<212> PRT
<213> Homo sapiens

<400> 6936
Met Asp Pro Phe Thr Glu Lys Leu Leu Glu Arg Thr Arg Ala Arg Arg 
1               5                   10                  15      


Glu Asn Leu Gln Arg Lys Met Ala Glu Arg Pro Thr Ala Ala Pro Arg 
            20                  25                  30          


Ser Met Thr His Ala Lys Arg Ala Arg Gln Pro Leu Ser Glu Ala Ser 
        35                  40                  45              


Asn Gln Gln Pro Leu Ser Gly Gly Glu Glu Lys Ser Cys Thr Lys Pro 
    50                  55                  60                  


Ser Pro Ser Lys Lys Arg Cys Ser Asp Asn Thr Glu Val Glu Val Ser 
65                  70                  75                  80  


Asn Leu Glu Asn Lys Gln Pro Val Glu Ser Thr Ser Ala Lys Ser Cys 
                85                  90                  95      


Ser Pro Ser Pro Val Ser Pro Gln Val Gln Pro Gln Ala Ala Asp Thr 
            100                 105                 110         


Ile Ser Asp Ser Val Ala Val Pro Ala Ser Leu Leu Gly Met Arg Arg 
        115                 120                 125             


Gly Leu Asn Ser Arg Leu Glu Ala Thr Ala Ala Ser Ser Val Lys Thr 
    130                 135                 140                 


Arg Met Gln Lys Leu Ala Glu Gln Arg Arg Arg Trp Asp Asn Asp Asp 
145                 150                 155                 160 


Met Thr Asp Asp Ile Pro Glu Ser Ser Leu Phe Ser Pro Met Pro Ser 
                165                 170                 175     


Glu Glu Lys Ala Ala Ser Pro Pro Arg Pro Leu Leu Ser Asn Ala Ser 
            180                 185                 190         


Ala Thr Pro Val Gly Arg Arg Gly Arg Leu Ala Asn Leu Ala Ala Thr 
        195                 200                 205             


Ile Cys Ser Trp Glu Asp Asp Val Asn His Ser Phe Ala Lys Gln Asn 
    210                 215                 220                 


Ser Val Gln Glu Gln Pro Gly Thr Ala Cys Leu Ser Lys Phe Ser Ser 
225                 230                 235                 240 


Ala Ser Gly Ala Ser Ala Arg Ile Asn Ser Ser Ser Val Lys Gln Glu 
                245                 250                 255     


Ala Thr Phe Cys Ser Gln Arg Asp Gly Asp Ala Ser Leu Asn Lys Ala 
            260                 265                 270         


Leu Ser Ser Ser Ala Asp Asp Ala Ser Leu Val Asn Ala Ser Ile Ser 
        275                 280                 285             


Ser Ser Val Lys Ala Thr Ser Pro Val Lys Ser Thr Thr Ser Ile Thr 
    290                 295                 300                 


Asp Ala Lys Ser Cys Glu Gly Gln Asn Pro Glu Leu Leu Pro Lys Thr 
305                 310                 315                 320 


Pro Ile Ser Pro Leu Lys Thr Gly Val Ser Lys Pro Ile Val Lys Ser 
                325                 330                 335     


Thr Leu Ser Gln Thr Val Pro Ser Lys Gly Glu Leu Ser Arg Glu Ile 
            340                 345                 350         


Cys Leu Gln Ser Gln Ser Lys Asp Lys Ser Thr Thr Pro Gly Gly Thr 
        355                 360                 365             


Gly Ile Lys Pro Phe Leu Glu Arg Phe Gly Glu Arg Cys Gln Glu His 
    370                 375                 380                 


Ser Lys Glu Ser Pro Ala Arg Ser Thr Pro His Arg Thr Pro Ile Ile 
385                 390                 395                 400 


Thr Pro Asn Thr Lys Ala Ile Gln Glu Arg Leu Phe Lys Gln Asp Thr 
                405                 410                 415     


Ser Ser Ser Thr Thr His Leu Ala Gln Gln Leu Lys Gln Glu Arg Gln 
            420                 425                 430         


Lys Glu Leu Ala Cys Leu Arg Gly Arg Phe Asp Lys Gly Asn Ile Trp 
        435                 440                 445             


Ser Ala Glu Lys Gly Gly Asn Ser Lys Ser Lys Gln Leu Glu Thr Lys 
    450                 455                 460                 


Gln Glu Thr His Cys Gln Ser Thr Pro Leu Lys Lys His Gln Gly Val 
465                 470                 475                 480 


Ser Lys Thr Gln Ser Leu Pro Val Thr Glu Lys Val Thr Glu Asn Gln 
                485                 490                 495     


Ile Pro Ala Lys Asn Ser Ser Thr Glu Pro Lys Glu Val Ile Arg Glu 
            500                 505                 510         


Ile Glu Met Ser Val Asp Asp Asp Asp Ile Asn Ser Ser Lys Val Ile 
        515                 520                 525             


Asn Asp Leu Phe Ser Asp Val Leu Glu Glu Gly Glu Leu Asp Met Glu 
    530                 535                 540                 


Lys Ser Gln Glu Glu Met Asp Gln Ala Leu Ala Glu Ser Ser Glu Glu 
545                 550                 555                 560 


Gln Glu Asp Ala Leu Asn Ile Ser Ser Met Ser Leu Leu Ala Pro Leu 
                565                 570                 575     


Ala Gln Thr Val Gly Val Val Ser Pro Glu Ser Leu Val Ser Thr Pro 
            580                 585                 590         


Arg Leu Glu Leu Lys Asp Thr Ser Arg Ser Asp Glu Ser Pro Lys Pro 
        595                 600                 605             


Gly Lys Phe Gln Arg Thr Arg Val Pro Arg Ala Glu Ser Gly Asp Ser 
    610                 615                 620                 


Leu Gly Ser Glu Asp Arg Asp Leu Leu Tyr Ser Ile Asp Ala Tyr Arg 
625                 630                 635                 640 


Ser Gln Arg Phe Lys Glu Thr Glu Arg Pro Ser Ile Lys Gln Val Ile 
                645                 650                 655     


Val Arg Lys Glu Asp Val Thr Ser Lys Leu Asp Glu Lys Asn Asn Ala 
            660                 665                 670         


Phe Pro Cys Gln Val Asn Ile Lys Gln Lys Met Gln Glu Leu Asn Asn 
        675                 680                 685             


Glu Ile Asn Met Gln Gln Thr Val Ile Tyr Gln Ala Ser Gln Ala Leu 
    690                 695                 700                 


Asn Cys Cys Val Asp Glu Glu His Gly Lys Gly Ser Leu Glu Glu Ala 
705                 710                 715                 720 


Glu Ala Glu Arg Leu Leu Leu Ile Ala Thr Gly Lys Arg Thr Leu Leu 
                725                 730                 735     


Ile Asp Glu Leu Asn Lys Leu Lys Asn Glu Gly Pro Gln Arg Lys Asn 
            740                 745                 750         


Lys Ala Ser Pro Gln Ser Glu Phe Met Pro Ser Lys Gly Ser Val Thr 
        755                 760                 765             


Leu Ser Glu Ile Arg Leu Pro Leu Lys Ala Asp Phe Val Cys Ser Thr 
    770                 775                 780                 


Val Gln Lys Pro Asp Ala Ala Asn Tyr Tyr Tyr Leu Ile Ile Leu Lys 
785                 790                 795                 800 


Ala Gly Ala Glu Asn Met Val Ala Thr Pro Leu Ala Ser Thr Ser Asn 
                805                 810                 815     


Ser Leu Asn Gly Asp Ala Leu Thr Phe Thr Thr Thr Phe Thr Leu Gln 
            820                 825                 830         


Asp Val Ser Asn Asp Phe Glu Ile Asn Ile Glu Val Tyr Ser Leu Val 
        835                 840                 845             


Gln Lys Lys Asp Pro Ser Gly Leu Asp Lys Lys Lys Lys Thr Ser Lys 
    850                 855                 860                 


Ser Lys Ala Ile Thr Pro Lys Arg Leu Leu Thr Ser Ile Thr Thr Lys 
865                 870                 875                 880 


Ser Asn Ile His Ser Ser Val Met Ala Ser Pro Gly Gly Leu Ser Ala 
                885                 890                 895     


Val Arg Thr Ser Asn Phe Ala Leu Val Gly Ser Tyr Thr Leu Ser Leu 
            900                 905                 910         


Ser Ser Val Gly Asn Thr Lys Phe Val Leu Asp Lys Val Pro Phe Leu 
        915                 920                 925             


Ser Ser Leu Glu Gly His Ile Tyr Leu Lys Ile Lys Cys Gln Val Asn 
    930                 935                 940                 


Ser Ser Val Glu Glu Arg Gly Phe Leu Thr Ile Phe Glu Asp Val Ser 
945                 950                 955                 960 


Gly Phe Gly Ala Trp His Arg Arg Trp Cys Val Leu Ser Gly Asn Cys 
                965                 970                 975     


Ile Ser Tyr Trp Thr Tyr Pro Asp Asp Glu Lys Arg Lys Asn Pro Ile 
            980                 985                 990         


Gly Arg Ile Asn Leu Ala Asn Cys  Thr Ser Arg Gln Ile  Glu Pro Ala 
        995                 1000                 1005             


Asn Arg  Glu Phe Cys Ala Arg  Arg Asn Thr Phe Glu  Leu Ile Thr 
    1010                 1015                 1020             


Val Arg  Pro Gln Arg Glu Asp  Asp Arg Glu Thr Leu  Val Ser Gln 
    1025                 1030                 1035             


Cys Arg  Asp Thr Leu Cys Val  Thr Lys Asn Trp Leu  Ser Ala Asp 
    1040                 1045                 1050             


Thr Lys  Glu Glu Arg Asp Leu  Trp Met Gln Lys Leu  Asn Gln Val 
    1055                 1060                 1065             


Leu Val  Asp Ile Arg Leu Trp  Gln Pro Asp Ala Cys  Tyr Lys Pro 
    1070                 1075                 1080             


Ile Gly  Lys Pro 
    1085         


<210> 6937
<211> 215
<212> PRT
<213> Homo sapiens

<400> 6937
Met Val Phe Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser 
1               5                   10                  15      


Phe Gly Pro His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp 
            20                  25                  30          


Gln Asn Arg Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln 
        35                  40                  45              


Ala Met Pro Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe 
    50                  55                  60                  


Pro His Ser Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala 
65                  70                  75                  80  


Asp Ile Asn Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu 
                85                  90                  95      


Ala Arg Glu Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val 
            100                 105                 110         


Met Lys Ala Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Glu Val Lys 
        115                 120                 125             


Lys Leu Gln Lys Ala Ala Leu Leu Lys Ala Ser Pro Lys Lys Ala Pro 
    130                 135                 140                 


Gly Thr Lys Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Val Pro Ala Lys Lys Ile Thr Ala Ala Ser Lys Lys Ala Pro Ala Gln 
                165                 170                 175     


Lys Val Pro Ala Gln Lys Ala Thr Gly Gln Lys Ala Ala Pro Ala Pro 
            180                 185                 190         


Lys Ala Gln Lys Gly Gln Lys Ala Pro Ala Gln Lys Ala Pro Ala Pro 
        195                 200                 205             


Lys Ala Ser Gly Lys Lys Ala 
    210                 215 


<210> 6938
<211> 991
<212> PRT
<213> Homo sapiens

<400> 6938
Met Glu Glu Tyr Glu Lys Phe Cys Glu Lys Ser Leu Ala Arg Ile Gln 
1               5                   10                  15      


Glu Ala Ser Leu Ser Thr Glu Ser Phe Leu Pro Ala Gln Ser Glu Ser 
            20                  25                  30          


Ile Ser Leu Ile Arg Phe His Gly Val Ala Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ile Glu Lys Arg Lys Glu Met Gln Gln Glu Lys Gln Lys Ala Leu 
    50                  55                  60                  


Asp Val Glu Ala Arg Lys Gln Val Asn Arg Lys Lys Ala Leu Leu Thr 
65                  70                  75                  80  


Arg Val Gln Glu Ile Leu Asp Asn Val Gln Val Arg Lys Ala Pro Asn 
                85                  90                  95      


Ala Ser Asp Phe Asp Gln Trp Glu Met Glu Thr Val Tyr Ser Asn Ser 
            100                 105                 110         


Glu Val Arg Asn Leu Asn Val Pro Ala Thr Phe Pro Asn Ser Phe Pro 
        115                 120                 125             


Ser His Thr Glu His Ser Thr Ala Ala Lys Leu Asp Lys Ile Ala Gly 
    130                 135                 140                 


Ile Leu Pro Leu Asp Asn Glu Asp Gln Cys Lys Thr Asp Gly Ile Asp 
145                 150                 155                 160 


Leu Ala Arg Asp Ser Glu Gly Phe Asn Ser Pro Lys Gln Cys Asp Ser 
                165                 170                 175     


Ser Asn Ile Ser His Val Glu Asn Glu Ala Phe Pro Lys Thr Ser Ser 
            180                 185                 190         


Ala Thr Pro Gln Glu Thr Leu Ile Ser Asp Gly Pro Phe Ser Val Asn 
        195                 200                 205             


Glu Gln Gln Asp Leu Pro Leu Leu Ala Glu Val Ile Pro Asp Pro Tyr 
    210                 215                 220                 


Val Met Ser Leu Gln Asn Leu Met Lys Lys Ser Lys Glu Tyr Ile Glu 
225                 230                 235                 240 


Arg Glu Gln Ser Arg Arg Ser Leu Arg Gly Ser Ile Asn Arg Ile Val 
                245                 250                 255     


Asn Glu Ser His Leu Asp Lys Glu His Asp Ala Val Glu Val Ala Asp 
            260                 265                 270         


Cys Val Lys Glu Lys Gly Gln Leu Thr Gly Lys His Cys Val Ser Val 
        275                 280                 285             


Ile Pro Asp Lys Pro Ser Leu Asn Lys Ser Asn Val Leu Leu Gln Gly 
    290                 295                 300                 


Ala Ser Thr Gln Ala Ser Ser Met Ser Met Pro Val Leu Ala Ser Phe 
305                 310                 315                 320 


Ser Lys Val Asp Ile Pro Ile Arg Thr Gly His Pro Thr Val Leu Glu 
                325                 330                 335     


Ser Asn Ser Asp Phe Lys Val Ile Pro Thr Phe Val Thr Glu Asn Asn 
            340                 345                 350         


Val Ile Lys Ser Leu Thr Gly Ser Tyr Ala Lys Leu Pro Ser Pro Glu 
        355                 360                 365             


Pro Ser Met Ser Pro Lys Met His Arg Arg Arg Ser Arg Thr Ser Ser 
    370                 375                 380                 


Ala Cys His Ile Leu Ile Asn Asn Pro Ile Asn Ala Cys Glu Leu Ser 
385                 390                 395                 400 


Pro Lys Gly Lys Glu Gln Ala Met Asp Leu Ile Ile Gln Asp Thr Asp 
                405                 410                 415     


Glu Asn Thr Asn Val Pro Glu Ile Met Pro Lys Leu Pro Thr Asp Leu 
            420                 425                 430         


Ala Gly Val Cys Ser Ser Lys Val Tyr Val Gly Lys Asn Thr Ser Glu 
        435                 440                 445             


Val Lys Glu Asp Val Val Leu Gly Lys Ser Asn Gln Val Cys Gln Ser 
    450                 455                 460                 


Ser Gly Asn His Leu Glu Asn Lys Val Thr His Gly Leu Val Thr Val 
465                 470                 475                 480 


Glu Gly Gln Leu Thr Ser Asp Glu Arg Gly Ala His Ile Met Asn Ser 
                485                 490                 495     


Thr Cys Ala Ala Met Pro Lys Leu His Glu Pro Tyr Ala Ser Ser Gln 
            500                 505                 510         


Cys Ile Ala Ser Pro Asn Phe Gly Thr Val Ser Gly Leu Lys Pro Ala 
        515                 520                 525             


Ser Met Leu Glu Lys Asn Cys Ser Leu Gln Thr Glu Leu Asn Lys Ser 
    530                 535                 540                 


Tyr Asp Val Lys Asn Pro Ser Pro Leu Leu Met Gln Asn Gln Asn Thr 
545                 550                 555                 560 


Arg Gln Gln Met Asp Thr Pro Met Val Ser Cys Gly Asn Glu Gln Phe 
                565                 570                 575     


Leu Asp Asn Ser Phe Glu Lys Val Lys Arg Arg Leu Asp Leu Asp Ile 
            580                 585                 590         


Asp Gly Leu Gln Lys Glu Asn Cys Pro Tyr Val Ile Thr Ser Gly Ile 
        595                 600                 605             


Thr Glu Gln Glu Arg Gln His Leu Pro Glu Lys Arg Tyr Pro Lys Gly 
    610                 615                 620                 


Ser Gly Phe Val Asn Lys Asn Lys Met Leu Gly Thr Ser Ser Lys Glu 
625                 630                 635                 640 


Ser Glu Glu Leu Leu Lys Ser Lys Met Leu Ala Phe Glu Glu Met Arg 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln His Ala Gln Gln Leu Ser Leu Leu Ile Ala 
            660                 665                 670         


Glu Gln Glu Arg Glu Gln Glu Arg Leu Gln Lys Glu Ile Glu Glu Gln 
        675                 680                 685             


Glu Lys Met Leu Lys Glu Lys Lys Ala Met Thr Ala Glu Ala Ser Glu 
    690                 695                 700                 


Leu Asp Ile Asn Asn Ala Val Glu Leu Glu Trp Arg Lys Ile Ser Asp 
705                 710                 715                 720 


Ser Ser Leu Leu Glu Thr Met Leu Ser Gln Ala Asp Ser Leu His Thr 
                725                 730                 735     


Ser Asn Ser Asn Ser Ser Gly Phe Thr Asn Ser Ala Met Gln Tyr Ser 
            740                 745                 750         


Phe Val Ser Ala Asn Glu Ala Pro Phe Tyr Leu Trp Gly Ser Ser Thr 
        755                 760                 765             


Ser Gly Leu Thr Lys Leu Ser Val Thr Arg Pro Phe Gly Arg Ala Lys 
    770                 775                 780                 


Thr Arg Trp Ser Gln Val Phe Ser Leu Glu Ile Gln Ala Lys Phe Asn 
785                 790                 795                 800 


Lys Ile Thr Ala Val Ala Lys Gly Phe Leu Thr Arg Arg Leu Met Gln 
                805                 810                 815     


Thr Asp Lys Leu Lys Gln Leu Arg Gln Thr Val Lys Asp Thr Met Glu 
            820                 825                 830         


Phe Ile Arg Ser Phe Gln Ser Glu Ala Pro Leu Lys Arg Gly Ile Val 
        835                 840                 845             


Ser Ala Gln Asp Ala Ser Leu Gln Glu Arg Val Leu Ala Gln Leu Arg 
    850                 855                 860                 


Ala Ala Leu Tyr Gly Ile His Asp Ile Phe Phe Val Met Asp Ala Ala 
865                 870                 875                 880 


Glu Arg Met Ser Ile Leu His His Asp Arg Glu Val Arg Lys Glu Lys 
                885                 890                 895     


Met Leu Arg Gln Met Asp Lys Met Lys Ser Pro Arg Val Ala Leu Ser 
            900                 905                 910         


Ala Ala Thr Gln Lys Ser Leu Asp Arg Lys Lys Tyr Met Lys Ala Ala 
        915                 920                 925             


Glu Met Gly Met Pro Asn Lys Lys Phe Leu Val Lys Gln Asn Pro Ser 
    930                 935                 940                 


Glu Thr Arg Val Leu Gln Pro Asn Gln Gly Gln Asn Ala Pro Val His 
945                 950                 955                 960 


Arg Leu Leu Ser Arg Gln Gly Ser Ile Cys Arg Lys Asn Pro Lys Lys 
                965                 970                 975     


Ala Ala Lys Cys Cys Asp Asn Leu Arg Arg Gln His Ser Leu Gly 
            980                 985                 990     


<210> 6939
<211> 991
<212> PRT
<213> Homo sapiens

<400> 6939
Met Glu Glu Tyr Glu Lys Phe Cys Glu Lys Ser Leu Ala Arg Ile Gln 
1               5                   10                  15      


Glu Ala Ser Leu Ser Thr Glu Ser Phe Leu Pro Ala Gln Ser Glu Ser 
            20                  25                  30          


Ile Ser Leu Ile Arg Phe His Gly Val Ala Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ile Glu Lys Arg Lys Glu Met Gln Gln Glu Lys Gln Lys Ala Leu 
    50                  55                  60                  


Asp Val Glu Ala Arg Lys Gln Val Asn Arg Lys Lys Ala Leu Leu Thr 
65                  70                  75                  80  


Arg Val Gln Glu Ile Leu Asp Asn Val Gln Val Arg Lys Ala Pro Asn 
                85                  90                  95      


Ala Ser Asp Phe Asp Gln Trp Glu Met Glu Thr Val Tyr Ser Asn Ser 
            100                 105                 110         


Glu Val Arg Asn Leu Asn Val Pro Ala Thr Phe Pro Asn Ser Phe Pro 
        115                 120                 125             


Ser His Thr Glu His Ser Thr Ala Ala Lys Leu Asp Lys Ile Ala Gly 
    130                 135                 140                 


Ile Leu Pro Leu Asp Asn Glu Asp Gln Cys Lys Thr Asp Gly Ile Asp 
145                 150                 155                 160 


Leu Ala Arg Asp Ser Glu Gly Phe Asn Ser Pro Lys Gln Cys Asp Ser 
                165                 170                 175     


Ser Asn Ile Ser His Val Glu Asn Glu Ala Phe Pro Lys Thr Ser Ser 
            180                 185                 190         


Ala Thr Pro Gln Glu Thr Leu Ile Ser Asp Gly Pro Phe Ser Val Asn 
        195                 200                 205             


Glu Gln Gln Asp Leu Pro Leu Leu Ala Glu Val Ile Pro Asp Pro Tyr 
    210                 215                 220                 


Val Met Ser Leu Gln Asn Leu Met Lys Lys Ser Lys Glu Tyr Ile Glu 
225                 230                 235                 240 


Arg Glu Gln Ser Arg Arg Ser Leu Arg Gly Ser Ile Asn Arg Ile Val 
                245                 250                 255     


Asn Glu Ser His Leu Asp Lys Glu His Asp Ala Val Glu Val Ala Asp 
            260                 265                 270         


Cys Val Lys Glu Lys Gly Gln Leu Thr Gly Lys His Cys Val Ser Val 
        275                 280                 285             


Ile Pro Asp Lys Pro Ser Leu Asn Lys Ser Asn Val Leu Leu Gln Gly 
    290                 295                 300                 


Ala Ser Thr Gln Ala Ser Ser Met Ser Met Pro Val Leu Ala Ser Phe 
305                 310                 315                 320 


Ser Lys Val Asp Ile Pro Ile Arg Thr Gly His Pro Thr Val Leu Glu 
                325                 330                 335     


Ser Asn Ser Asp Phe Lys Val Ile Pro Thr Phe Val Thr Glu Asn Asn 
            340                 345                 350         


Val Ile Lys Ser Leu Thr Gly Ser Tyr Ala Lys Leu Pro Ser Pro Glu 
        355                 360                 365             


Pro Ser Met Ser Pro Lys Met His Arg Arg Arg Ser Arg Thr Ser Ser 
    370                 375                 380                 


Ala Cys His Ile Leu Ile Asn Asn Pro Ile Asn Ala Cys Glu Leu Ser 
385                 390                 395                 400 


Pro Lys Gly Lys Glu Gln Ala Met Asp Leu Ile Ile Gln Asp Thr Asp 
                405                 410                 415     


Glu Asn Thr Asn Val Pro Glu Ile Met Pro Lys Leu Pro Thr Asp Leu 
            420                 425                 430         


Ala Gly Val Cys Ser Ser Lys Val Tyr Val Gly Lys Asn Thr Ser Glu 
        435                 440                 445             


Val Lys Glu Asp Val Val Leu Gly Lys Ser Asn Gln Val Cys Gln Ser 
    450                 455                 460                 


Ser Gly Asn His Leu Glu Asn Lys Val Thr His Gly Leu Val Thr Val 
465                 470                 475                 480 


Glu Gly Gln Leu Thr Ser Asp Glu Arg Gly Ala His Ile Met Asn Ser 
                485                 490                 495     


Thr Cys Ala Ala Met Pro Lys Leu His Glu Pro Tyr Ala Ser Ser Gln 
            500                 505                 510         


Cys Ile Ala Ser Pro Asn Phe Gly Thr Val Ser Gly Leu Lys Pro Ala 
        515                 520                 525             


Ser Met Leu Glu Lys Asn Cys Ser Leu Gln Thr Glu Leu Asn Lys Ser 
    530                 535                 540                 


Tyr Asp Val Lys Asn Pro Ser Pro Leu Leu Met Gln Asn Gln Asn Thr 
545                 550                 555                 560 


Arg Gln Gln Met Asp Thr Pro Met Val Ser Cys Gly Asn Glu Gln Phe 
                565                 570                 575     


Leu Asp Asn Ser Phe Glu Lys Val Lys Arg Arg Leu Asp Leu Asp Ile 
            580                 585                 590         


Asp Gly Leu Gln Lys Glu Asn Cys Pro Tyr Val Ile Thr Ser Gly Ile 
        595                 600                 605             


Thr Glu Gln Glu Arg Gln His Leu Pro Glu Lys Arg Tyr Pro Lys Gly 
    610                 615                 620                 


Ser Gly Phe Val Asn Lys Asn Lys Met Leu Gly Thr Ser Ser Lys Glu 
625                 630                 635                 640 


Ser Glu Glu Leu Leu Lys Ser Lys Met Leu Ala Phe Glu Glu Met Arg 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln His Ala Gln Gln Leu Ser Leu Leu Ile Ala 
            660                 665                 670         


Glu Gln Glu Arg Glu Gln Glu Arg Leu Gln Lys Glu Ile Glu Glu Gln 
        675                 680                 685             


Glu Lys Met Leu Lys Glu Lys Lys Ala Met Thr Ala Glu Ala Ser Glu 
    690                 695                 700                 


Leu Asp Ile Asn Asn Ala Val Glu Leu Glu Trp Arg Lys Ile Ser Asp 
705                 710                 715                 720 


Ser Ser Leu Leu Glu Thr Met Leu Ser Gln Ala Asp Ser Leu His Thr 
                725                 730                 735     


Ser Asn Ser Asn Ser Ser Gly Phe Thr Asn Ser Ala Met Gln Tyr Ser 
            740                 745                 750         


Phe Val Ser Ala Asn Glu Ala Pro Phe Tyr Leu Trp Gly Ser Ser Thr 
        755                 760                 765             


Ser Gly Leu Thr Lys Leu Ser Val Thr Arg Pro Phe Gly Arg Ala Lys 
    770                 775                 780                 


Thr Arg Trp Ser Gln Val Phe Ser Leu Glu Ile Gln Ala Lys Phe Asn 
785                 790                 795                 800 


Lys Ile Thr Ala Val Ala Lys Gly Phe Leu Thr Arg Arg Leu Met Gln 
                805                 810                 815     


Thr Asp Lys Leu Lys Gln Leu Arg Gln Thr Val Lys Asp Thr Met Glu 
            820                 825                 830         


Phe Ile Arg Ser Phe Gln Ser Glu Ala Pro Leu Lys Arg Gly Ile Val 
        835                 840                 845             


Ser Ala Gln Asp Ala Ser Leu Gln Glu Arg Val Leu Ala Gln Leu Arg 
    850                 855                 860                 


Ala Ala Leu Tyr Gly Ile His Asp Ile Phe Phe Val Met Asp Ala Ala 
865                 870                 875                 880 


Glu Arg Met Ser Ile Leu His His Asp Arg Glu Val Arg Lys Glu Lys 
                885                 890                 895     


Met Leu Arg Gln Met Asp Lys Met Lys Ser Pro Arg Val Ala Leu Ser 
            900                 905                 910         


Ala Ala Thr Gln Lys Ser Leu Asp Arg Lys Lys Tyr Met Lys Ala Ala 
        915                 920                 925             


Glu Met Gly Met Pro Asn Lys Lys Phe Leu Val Lys Gln Asn Pro Ser 
    930                 935                 940                 


Glu Thr Arg Val Leu Gln Pro Asn Gln Gly Gln Asn Ala Pro Val His 
945                 950                 955                 960 


Arg Leu Leu Ser Arg Gln Gly Ser Ile Cys Arg Lys Asn Pro Lys Lys 
                965                 970                 975     


Ala Ala Lys Cys Cys Asp Asn Leu Arg Arg Gln His Ser Leu Gly 
            980                 985                 990     


<210> 6940
<211> 332
<212> PRT
<213> Homo sapiens

<400> 6940
Met Ala Thr Ile Lys Ser Glu Leu Ile Lys Asn Phe Ala Glu Glu Glu 
1               5                   10                  15      


Ala Ile His His Asn Lys Ile Ser Ile Val Gly Thr Gly Ser Val Gly 
            20                  25                  30          


Val Ala Cys Ala Ile Ser Ile Leu Leu Lys Gly Leu Ser Asp Glu Leu 
        35                  40                  45              


Val Leu Val Asp Val Asp Glu Gly Lys Leu Lys Gly Glu Thr Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Pro Phe Met Lys Met Pro Asn Ile Val Ser Ser 
65                  70                  75                  80  


Lys Asp Tyr Leu Val Thr Ala Asn Ser Asn Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Lys Lys Gly Glu Thr Arg Leu Asp Leu Val Gln Arg 
            100                 105                 110         


Asn Val Ser Ile Phe Lys Leu Met Ile Pro Asn Ile Thr Gln Tyr Ser 
        115                 120                 125             


Pro His Cys Lys Leu Leu Ile Val Thr Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Leu Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Phe Ile Gly Gln 
                165                 170                 175     


Arg Leu Gly Ile His Ser Glu Ser Cys His Gly Leu Ile Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Val Asn Ile Ala Gly 
        195                 200                 205             


Val Pro Leu Lys Asp Leu Asn Pro Asp Ile Gly Thr Asp Lys Asp Pro 
    210                 215                 220                 


Glu Gln Trp Glu Asn Val His Lys Lys Val Ile Ser Ser Gly Tyr Glu 
225                 230                 235                 240 


Met Val Lys Met Lys Gly Tyr Thr Ser Trp Gly Ile Ser Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Thr Glu Ser Ile Leu Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Leu Ser Lys Gly Leu Tyr Gly Ile Asn Glu Asp Ile Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Glu Asn Gly Ile Thr Asp Leu Ile 
    290                 295                 300                 


Lys Val Lys Leu Thr Leu Glu Glu Glu Ala Cys Leu Gln Lys Ser Ala 
305                 310                 315                 320 


Glu Thr Leu Trp Glu Ile Gln Lys Glu Leu Lys Leu 
                325                 330         


<210> 6941
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6941
Met Met Ala Lys Lys Pro Pro Lys Pro Ala Pro Arg Arg Ile Phe Gln 
1               5                   10                  15      


Glu Arg Leu Lys Ile Thr Ala Leu Pro Leu Tyr Phe Glu Gly Phe Leu 
            20                  25                  30          


Leu Ile Lys Arg Ser Gly Tyr Arg Glu Tyr Glu His Tyr Trp Thr Glu 
        35                  40                  45              


Leu Arg Gly Thr Thr Leu Phe Phe Tyr Thr Asp Lys Lys Ser Ile Ile 
    50                  55                  60                  


Tyr Val Asp Lys Leu Asp Ile Val Asp Leu Thr Cys Leu Thr Glu Gln 
65                  70                  75                  80  


Asn Ser Thr Glu Lys Asn Cys Ala Lys Phe Thr Leu Val Leu Pro Lys 
                85                  90                  95      


Glu Glu Val Gln Leu Lys Thr Glu Asn Thr Glu Ser Gly Glu Glu Trp 
            100                 105                 110         


Arg Gly Phe Ile Leu Thr Val Thr Glu Leu Ser Val Pro Gln Asn Val 
        115                 120                 125             


Ser Leu Leu Pro Gly Gln Val Ile Lys Leu His Glu Val Leu Glu Arg 
    130                 135                 140                 


Glu Lys Lys Arg Arg Ile Glu Thr Glu Gln Ser Thr Ser Val Glu Lys 
145                 150                 155                 160 


Glu Lys Glu Pro Thr Glu Asp Tyr Val Asp Val Leu Asn Pro Met Pro 
                165                 170                 175     


Ala Cys Phe Tyr Thr Val Ser Arg Lys Glu Ala Thr Glu Met Leu Gln 
            180                 185                 190         


Lys Asn Pro Ser Leu Gly Asn Met Ile Leu Arg Pro Gly Ser Asp Ser 
        195                 200                 205             


Arg Asn Tyr Ser Ile Thr Ile Arg Gln Glu Ile Asp Ile Pro Arg Ile 
    210                 215                 220                 


Lys His Tyr Lys Val Met Ser Val Gly Gln Asn Tyr Thr Ile Glu Leu 
225                 230                 235                 240 


Glu Lys Pro Val Thr Leu Pro Asn Leu Phe Ser Val Ile Asp Tyr Phe 
                245                 250                 255     


Val Lys Glu Thr Arg Gly Asn Leu Arg Pro Phe Ile Cys Ser Thr Asp 
            260                 265                 270         


Glu Asn Thr Gly Gln Glu Pro Ser Met Glu Gly Arg Ser Glu Lys Leu 
        275                 280                 285             


Lys Lys Asn Pro His Ile Ala 
    290                 295 


<210> 6942
<211> 455
<212> PRT
<213> Homo sapiens

<400> 6942
Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln 
1               5                   10                  15      


Pro Arg Trp Phe Leu Leu Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser 
            20                  25                  30          


Pro Glu Asp Ala Trp Lys Gly Cys Lys Gly Ser Ile Gln Met Ala Val 
        35                  40                  45              


Cys Glu Ile Gln Val His Ser Val Asp Asn Thr Arg Met Asp Leu Ile 
    50                  55                  60                  


Ile Pro Gly Glu Gln Tyr Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu 
65                  70                  75                  80  


Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr 
                85                  90                  95      


Asp Ser Arg Thr Gln Lys Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn 
            100                 105                 110         


Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val 
        115                 120                 125             


Gln Gln Val Asp Lys Thr Lys Glu Val Thr Thr Thr Gly Val Ser Asn 
    130                 135                 140                 


Ser Glu Glu Gly Ile Asp Val Gly Thr Leu Leu Lys Ser Thr Cys Asn 
145                 150                 155                 160 


Thr Phe Leu Lys Thr Leu Glu Glu Cys Met Gln Ile Ala Asn Ala Ala 
                165                 170                 175     


Phe Thr Ser Glu Leu Leu Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu 
            180                 185                 190         


Ala Met Leu Lys Ser Ser Lys Met Lys His Pro Ile Ile Pro Ile His 
        195                 200                 205             


Asn Ser Leu Glu Arg Gln Met Glu Leu Ser Thr Cys Glu Asn Gly Ser 
    210                 215                 220                 


Leu Asn Met Glu Ile Asn Gly Glu Glu Glu Ile Leu Met Lys Asn Lys 
225                 230                 235                 240 


Asn Ser Leu Tyr Leu Lys Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser 
                245                 250                 255     


Glu Glu Asn Thr Asp Asp Asn Ile Thr Val Gln Gly Glu Ile Arg Lys 
            260                 265                 270         


Glu Asp Gly Met Glu Asn Leu Lys Asn His Asp Asn Asn Leu Thr Gln 
        275                 280                 285             


Ser Gly Ser Asp Ser Ser Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly 
    290                 295                 300                 


Lys Glu Val Ile Pro Thr Phe Phe Ser Thr Met Asn Thr Ser Phe Ser 
305                 310                 315                 320 


Asp Ile Glu Leu Leu Glu Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu 
                325                 330                 335     


Ala Ser Cys Tyr Ala Val Val Pro Val Leu Asp Lys Leu Gly Pro Thr 
            340                 345                 350         


Val Phe Ala Pro Val Lys Met Asp Leu Val Gly Asn Ile Lys Lys Val 
        355                 360                 365             


Asn Gln Lys Tyr Ile Thr Asn Lys Glu Glu Phe Thr Thr Leu Gln Lys 
    370                 375                 380                 


Ile Val Leu His Glu Val Glu Ala Asp Val Ala Gln Val Arg Asn Ser 
385                 390                 395                 400 


Ala Thr Glu Ala Leu Leu Trp Leu Lys Arg Gly Leu Lys Phe Leu Lys 
                405                 410                 415     


Gly Phe Leu Thr Glu Val Lys Asn Gly Glu Lys Asp Ile Gln Thr Ala 
            420                 425                 430         


Leu Asn Asn Ala Tyr Gly Lys Thr Leu Arg Gln His His Gly Trp Val 
        435                 440                 445             


Val Arg Gly Val Phe Ala Val 
    450                 455 


<210> 6943
<211> 439
<212> PRT
<213> Homo sapiens

<400> 6943
Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln 
1               5                   10                  15      


Pro Arg Trp Phe Leu Leu Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser 
            20                  25                  30          


Pro Glu Asp Ala Trp Lys Gly Cys Lys Gly Ser Ile Gln Met Ala Val 
        35                  40                  45              


Cys Glu Ile Gln Val His Ser Val Asp Asn Thr Arg Met Asp Leu Ile 
    50                  55                  60                  


Ile Pro Gly Glu Gln Tyr Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu 
65                  70                  75                  80  


Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr 
                85                  90                  95      


Asp Ser Arg Thr Gln Lys Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn 
            100                 105                 110         


Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val 
        115                 120                 125             


Gln Gln Val Asp Lys Thr Lys Glu Val Thr Thr Thr Gly Val Ser Asn 
    130                 135                 140                 


Ser Glu Glu Gly Ile Asp Val Gly Thr Leu Leu Lys Ser Thr Cys Asn 
145                 150                 155                 160 


Thr Phe Leu Lys Thr Leu Glu Glu Cys Met Gln Ile Ala Asn Ala Ala 
                165                 170                 175     


Phe Thr Ser Glu Leu Leu Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu 
            180                 185                 190         


Ala Met Leu Lys Ser Ser Lys Met Lys His Pro Ile Ile Pro Ile His 
        195                 200                 205             


Asn Ser Leu Glu Arg Gln Met Glu Leu Ser Thr Cys Glu Asn Gly Ser 
    210                 215                 220                 


Leu Asn Met Glu Ile Asn Gly Glu Glu Glu Ile Leu Met Lys Asn Lys 
225                 230                 235                 240 


Asn Ser Leu Tyr Leu Lys Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser 
                245                 250                 255     


Glu Glu Asn Thr Asp Asp Asn Ile Thr Val Gln Gly Glu Ile Arg Lys 
            260                 265                 270         


Glu Asp Gly Met Glu Asn Leu Lys Asn His Asp Asn Asn Leu Thr Gln 
        275                 280                 285             


Ser Gly Ser Asp Ser Ser Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly 
    290                 295                 300                 


Lys Glu Val Ile Pro Thr Phe Phe Ser Thr Met Asn Thr Ser Phe Ser 
305                 310                 315                 320 


Asp Ile Glu Leu Leu Glu Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu 
                325                 330                 335     


Ala Ser Cys Tyr Ala Val Val Pro Val Leu Asp Lys Leu Gly Pro Thr 
            340                 345                 350         


Val Phe Ala Pro Val Lys Met Asp Leu Val Gly Asn Ile Lys Lys Val 
        355                 360                 365             


Asn Gln Lys Tyr Ile Thr Asn Lys Glu Glu Phe Thr Thr Leu Gln Lys 
    370                 375                 380                 


Ile Val Leu His Glu Val Glu Ala Asp Val Ala Gln Val Arg Asn Ser 
385                 390                 395                 400 


Ala Thr Glu Ala Leu Leu Trp Leu Lys Arg Gly Leu Lys Phe Leu Lys 
                405                 410                 415     


Gly Phe Leu Thr Glu Val Lys Asn Gly Glu Lys Asp Ile Gln Thr Ala 
            420                 425                 430         


Leu Ser Val Gly Met Trp Val 
        435                 


<210> 6944
<211> 327
<212> PRT
<213> Homo sapiens

<400> 6944
Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp Asp 
1               5                   10                  15      


Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala Tyr Tyr Thr Arg 
            20                  25                  30          


His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Arg Thr Arg Ser Leu Ser Gln Arg Gly Leu Gly Asn Cys Ser Ala Asn 
    50                  55                  60                  


Glu Ser Trp Thr Glu Val Ser Trp Pro Cys Arg Asn Ser Gln Ser Ser 
65                  70                  75                  80  


Glu Lys Ala Ile Asn Leu Gly Lys Lys Lys Ser Ser Trp Lys Ala Phe 
                85                  90                  95      


Phe Gly Val Val Glu Lys Glu Asp Ser Gln Ser Thr Pro Ala Lys Val 
            100                 105                 110         


Ser Ala Gln Gly Gln Arg Thr Leu Glu Tyr Gln Asp Ser His Ser Gln 
        115                 120                 125             


Gln Trp Ser Arg Cys Leu Ser Asn Val Glu Gln Cys Leu Glu His Glu 
    130                 135                 140                 


Ala Val Asp Pro Lys Val Ile Ser Ile Ala Asn Arg Val Ala Glu Ile 
145                 150                 155                 160 


Val Tyr Ser Trp Pro Pro Pro Gln Ala Thr Gln Ala Gly Gly Phe Lys 
                165                 170                 175     


Ser Lys Glu Ile Phe Val Thr Glu Gly Leu Ser Phe Gln Leu Gln Gly 
            180                 185                 190         


His Val Pro Val Ala Ser Ser Ser Lys Lys Asp Glu Glu Glu Gln Ile 
        195                 200                 205             


Leu Ala Lys Ile Val Glu Leu Leu Lys Tyr Ser Gly Asp Gln Leu Glu 
    210                 215                 220                 


Arg Lys Leu Lys Lys Asp Lys Ala Leu Met Gly His Phe Gln Asp Gly 
225                 230                 235                 240 


Leu Ser Tyr Ser Val Phe Lys Thr Ile Thr Asp Gln Val Leu Met Gly 
                245                 250                 255     


Val Asp Pro Arg Gly Glu Ser Glu Val Lys Ala Gln Gly Phe Lys Ala 
            260                 265                 270         


Ala Leu Val Ile Asp Val Thr Ala Lys Leu Thr Ala Ile Asp Asn His 
        275                 280                 285             


Pro Met Asn Arg Val Leu Gly Phe Gly Thr Lys Tyr Leu Lys Glu Asn 
    290                 295                 300                 


Phe Ser Pro Trp Ile Gln Gln His Gly Gly Trp Glu Lys Ile Leu Gly 
305                 310                 315                 320 


Ile Ser His Glu Glu Val Asp 
                325         


<210> 6945
<211> 1742
<212> PRT
<213> Homo sapiens

<400> 6945
Met Met Glu Gly Asn Gly Thr Glu Asn Ser Cys Ser Arg Thr Arg Gly 
1               5                   10                  15      


Trp Leu Gln Gln Asp Asn Asp Ala Lys Pro Trp Leu Trp Lys Phe Ser 
            20                  25                  30          


Asn Cys Phe Ser Arg Pro Glu Gln Thr Leu Pro His Ser Pro Gln Thr 
        35                  40                  45              


Lys Glu Tyr Met Glu Asn Lys Lys Val Ala Val Glu Leu Lys Asp Val 
    50                  55                  60                  


Pro Ser Pro Leu His Ala Gly Ser Lys Leu Phe Pro Ala Val Pro Leu 
65                  70                  75                  80  


Pro Asp Ile Arg Ser Leu Gln Gln Pro Lys Ile Gln Leu Ser Ser Val 
                85                  90                  95      


Pro Lys Val Ser Cys Cys Ala His Cys Pro Asn Glu Pro Ser Thr Ser 
            100                 105                 110         


Pro Met Arg Phe Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Ser Ser 
        115                 120                 125             


Leu Ile His Pro Gly Ala Leu Leu Asp Ser Gln Ser Thr Arg Thr Ile 
    130                 135                 140                 


Thr Cys Gln Val Gly Ser Gly Phe Ala Phe Gln Ser Ala Ser Ser Leu 
145                 150                 155                 160 


Gln Asn Ala Ser Ala Arg Asn Asn Leu Ala Gly Ile Ala Ser Asp Phe 
                165                 170                 175     


Pro Ser Met Cys Leu Glu Ser Asn Leu Ser Ser Cys Lys His Leu Pro 
            180                 185                 190         


Cys Cys Gly Lys Leu His Phe Gln Ser Cys His Gly Asn Val His Lys 
        195                 200                 205             


Leu His Gln Phe Pro Ser Leu Gln Gly Cys Thr Ser Ala Gly Tyr Phe 
    210                 215                 220                 


Pro Cys Ser Asp Phe Thr Ser Gly Ala Pro Gly His Leu Glu Glu His 
225                 230                 235                 240 


Ile Ser Gln Ser Glu Leu Thr Pro His Leu Cys Thr Asn Ser Leu His 
                245                 250                 255     


Leu Asn Val Val Pro Pro Val Cys Leu Lys Gly Ser Leu Tyr Cys Glu 
            260                 265                 270         


Asp Cys Leu Asn Lys Pro Ala Arg Asn Ser Ile Ile Asp Ala Ala Lys 
        275                 280                 285             


Val Trp Pro Asn Ile Pro Pro Pro Asn Thr Gln Pro Ala Pro Leu Ala 
    290                 295                 300                 


Val Pro Leu Cys Asn Gly Cys Gly Thr Lys Gly Thr Gly Lys Glu Thr 
305                 310                 315                 320 


Thr Leu Leu Leu Ala Thr Ser Leu Gly Lys Ala Ala Ser Lys Phe Gly 
                325                 330                 335     


Ser Pro Glu Val Ala Val Ala Gly Gln Val Leu Glu Asn Leu Pro Pro 
            340                 345                 350         


Ile Gly Val Phe Trp Asp Ile Glu Asn Cys Ser Val Pro Ser Gly Arg 
        355                 360                 365             


Ser Ala Thr Ala Val Val Gln Arg Ile Arg Glu Lys Phe Phe Lys Gly 
    370                 375                 380                 


His Arg Glu Ala Glu Phe Ile Cys Val Cys Asp Ile Ser Lys Glu Asn 
385                 390                 395                 400 


Lys Glu Val Ile Gln Glu Leu Asn Asn Cys Gln Val Thr Val Ala His 
                405                 410                 415     


Ile Asn Ala Thr Ala Lys Asn Ala Ala Asp Asp Lys Leu Arg Gln Ser 
            420                 425                 430         


Leu Arg Arg Phe Ala Asn Thr His Thr Ala Pro Ala Thr Val Val Leu 
        435                 440                 445             


Val Ser Thr Asp Val Asn Phe Ala Leu Glu Leu Ser Asp Leu Arg His 
    450                 455                 460                 


Arg His Gly Phe His Ile Ile Leu Val His Lys Asn Gln Ala Ser Glu 
465                 470                 475                 480 


Ala Leu Leu His His Ala Asn Glu Leu Ile Arg Phe Glu Glu Phe Ile 
                485                 490                 495     


Ser Asp Leu Pro Pro Arg Leu Pro Leu Lys Met Pro Gln Cys His Thr 
            500                 505                 510         


Leu Leu Tyr Val Tyr Asn Leu Pro Ala Asn Lys Asp Gly Lys Ser Val 
        515                 520                 525             


Ser Asn Arg Leu Arg Arg Leu Ser Asp Asn Cys Gly Gly Lys Val Leu 
    530                 535                 540                 


Ser Ile Thr Gly Cys Ser Ala Ile Leu Arg Phe Ile Asn Gln Asp Ser 
545                 550                 555                 560 


Ala Glu Arg Ala Gln Lys Arg Met Glu Asn Glu Asp Val Phe Gly Asn 
                565                 570                 575     


Arg Ile Ile Val Ser Phe Thr Pro Lys Asn Arg Glu Leu Cys Glu Thr 
            580                 585                 590         


Lys Ser Ser Asn Ala Ile Ala Asp Lys Val Lys Ser Pro Lys Lys Leu 
        595                 600                 605             


Lys Asn Pro Lys Leu Cys Leu Ile Lys Asp Ala Ser Glu Gln Ser Ser 
    610                 615                 620                 


Ser Ala Lys Ala Thr Pro Gly Lys Gly Ser Gln Ala Asn Ser Gly Ser 
625                 630                 635                 640 


Ala Thr Lys Asn Thr Asn Val Lys Ser Leu Gln Glu Leu Cys Arg Met 
                645                 650                 655     


Glu Ser Lys Thr Gly His Arg Asn Ser Glu His Gln Gln Gly His Leu 
            660                 665                 670         


Arg Leu Val Val Pro Thr His Gly Asn Ser Ser Ala Ala Val Ser Thr 
        675                 680                 685             


Pro Lys Asn Ser Gly Val Ala Glu Pro Val Tyr Lys Thr Ser Gln Lys 
    690                 695                 700                 


Lys Glu Asn Leu Ser Ala Arg Ser Val Thr Ser Ser Pro Val Glu Lys 
705                 710                 715                 720 


Lys Asp Lys Glu Glu Thr Val Phe Gln Val Ser Tyr Pro Ser Ala Phe 
                725                 730                 735     


Ser Lys Leu Val Ala Ser Arg Gln Val Ser Pro Leu Leu Ala Ser Gln 
            740                 745                 750         


Ser Trp Ser Ser Arg Ser Met Ser Pro Asn Leu Leu Asn Arg Ala Ser 
        755                 760                 765             


Pro Leu Ala Phe Asn Ile Ala Asn Ser Ser Ser Glu Ala Asp Cys Pro 
    770                 775                 780                 


Asp Pro Phe Ala Asn Gly Ala Asp Val Gln Val Ser Asn Ile Asp Tyr 
785                 790                 795                 800 


Arg Leu Ser Arg Lys Glu Leu Gln Gln Leu Leu Gln Glu Ala Phe Ala 
                805                 810                 815     


Arg His Gly Lys Val Lys Ser Val Glu Leu Ser Pro His Thr Asp Tyr 
            820                 825                 830         


Gln Leu Lys Ala Val Val Gln Met Glu Asn Leu Gln Asp Ala Ile Gly 
        835                 840                 845             


Ala Val Asn Ser Leu His Arg Tyr Lys Ile Gly Ser Lys Lys Ile Leu 
    850                 855                 860                 


Val Ser Leu Ala Thr Gly Ala Ala Ser Lys Ser Leu Ser Leu Leu Ser 
865                 870                 875                 880 


Ala Glu Thr Met Ser Val Leu Gln Asp Ala Pro Ala Cys Cys Leu Pro 
                885                 890                 895     


Leu Phe Lys Phe Thr Asp Ile Tyr Glu Lys Lys Phe Gly His Lys Leu 
            900                 905                 910         


Asn Val Ser Asp Leu Tyr Lys Leu Thr Asp Thr Val Ala Ile Arg Glu 
        915                 920                 925             


Gln Gly Asn Gly Arg Leu Val Cys Leu Leu Pro Ser Ser Gln Ala Arg 
    930                 935                 940                 


Gln Ser Pro Leu Gly Ser Ser Gln Ser His Asp Gly Ser Ser Thr Asn 
945                 950                 955                 960 


Cys Ser Pro Ile Ile Phe Glu Glu Leu Glu Tyr His Glu Pro Val Cys 
                965                 970                 975     


Arg Gln His Cys Ser Asn Lys Asp Phe Ser Glu His Glu Phe Asp Pro 
            980                 985                 990         


Asp Ser Tyr Lys Ile Pro Phe Val  Ile Leu Ser Leu Lys  Thr Phe Ala 
        995                 1000                 1005             


Pro Gln  Val His Ser Leu Leu  Gln Thr His Glu Gly  Thr Val Pro 
    1010                 1015                 1020             


Leu Leu  Ser Phe Pro Asp Cys  Tyr Ile Ala Glu Phe  Gly Asp Leu 
    1025                 1030                 1035             


Glu Val  Val Gln Glu Asn Gln  Gly Gly Val Pro Leu  Glu His Phe 
    1040                 1045                 1050             


Ile Thr  Cys Val Pro Gly Val  Asn Ile Ala Thr Ala  Gln Asn Gly 
    1055                 1060                 1065             


Ile Lys  Val Val Lys Trp Ile  His Asn Lys Pro Pro  Pro Pro Asn 
    1070                 1075                 1080             


Thr Asp  Pro Trp Leu Leu Arg  Ser Lys Ser Pro Val  Gly Asn Pro 
    1085                 1090                 1095             


Gln Leu  Ile Gln Phe Ser Arg  Glu Val Ile Asp Leu  Leu Lys Ser 
    1100                 1105                 1110             


Gln Pro  Ser Cys Val Ile Pro  Ile Ser His Phe Ile  Pro Ser Tyr 
    1115                 1120                 1125             


His His  His Phe Ala Lys Gln  Cys Arg Val Ser Asp  Tyr Gly Tyr 
    1130                 1135                 1140             


Ser Lys  Leu Ile Glu Leu Leu  Glu Ala Val Pro His  Val Leu Gln 
    1145                 1150                 1155             


Ile Leu  Gly Met Gly Ser Lys  Arg Leu Leu Thr Leu  Thr His Arg 
    1160                 1165                 1170             


Ala Gln  Val Lys Arg Phe Thr  Gln Asp Leu Leu Lys  Leu Leu Lys 
    1175                 1180                 1185             


Ser Gln  Ala Ser Lys Gln Val  Ile Val Arg Glu Phe  Ser Gln Ala 
    1190                 1195                 1200             


Tyr His  Trp Cys Phe Ser Lys  Asp Trp Asp Val Thr  Glu Tyr Gly 
    1205                 1210                 1215             


Val Cys  Glu Leu Ile Asp Ile  Val Ser Glu Ile Pro  Asp Thr Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ser Gln Gln Asp  Asn Glu Met Val Ile  Cys Ile Pro 
    1235                 1240                 1245             


Lys Arg  Glu Arg Thr Gln Asp  Glu Ile Glu Arg Thr  Lys Gln Phe 
    1250                 1255                 1260             


Ser Lys  Asp Val Val Asp Leu  Leu Arg His Gln Pro  His Phe Arg 
    1265                 1270                 1275             


Met Pro  Phe Asn Lys Phe Ile  Pro Ser Tyr His His  His Phe Gly 
    1280                 1285                 1290             


Arg Gln  Cys Lys Leu Ala Tyr  Tyr Gly Phe Thr Lys  Leu Leu Glu 
    1295                 1300                 1305             


Leu Phe  Glu Ala Ile Pro Asp  Thr Leu Gln Val Leu  Glu Cys Gly 
    1310                 1315                 1320             


Glu Glu  Lys Ile Leu Thr Leu  Thr Glu Val Glu Arg  Phe Lys Ala 
    1325                 1330                 1335             


Leu Ala  Ala Gln Phe Val Lys  Leu Leu Arg Ser Gln  Lys Asp Asn 
    1340                 1345                 1350             


Cys Leu  Met Met Thr Asp Leu  Leu Thr Glu Tyr Ala  Lys Thr Phe 
    1355                 1360                 1365             


Gly Tyr  Thr Phe Arg Leu Gln  Asp Tyr Asp Val Ser  Ser Ile Ser 
    1370                 1375                 1380             


Ala Leu  Thr Gln Lys Leu Cys  His Val Val Lys Val  Ala Asp Ile 
    1385                 1390                 1395             


Glu Ser  Gly Arg Gln Ile Gln  Leu Ile Asn Arg Lys  Ser Leu Arg 
    1400                 1405                 1410             


Ser Leu  Thr Ala Gln Leu Leu  Val Leu Leu Met Ser  Trp Glu Gly 
    1415                 1420                 1425             


Thr Thr  His Leu Ser Val Glu  Glu Leu Lys Arg His  Tyr Glu Ser 
    1430                 1435                 1440             


Thr His  Asn Thr Pro Leu Asn  Pro Cys Glu Tyr Gly  Phe Met Thr 
    1445                 1450                 1455             


Leu Thr  Glu Leu Leu Lys Ser  Leu Pro Tyr Leu Val  Glu Val Phe 
    1460                 1465                 1470             


Thr Asn  Asp Lys Met Glu Glu  Cys Val Lys Leu Thr  Ser Leu Tyr 
    1475                 1480                 1485             


Leu Phe  Ala Lys Asn Val Arg  Ser Leu Leu His Thr  Tyr His Tyr 
    1490                 1495                 1500             


Gln Gln  Ile Phe Leu His Glu  Phe Ser Met Ala Tyr  Thr Lys Tyr 
    1505                 1510                 1515             


Val Gly  Glu Thr Leu Gln Pro  Lys Thr Tyr Gly His  Ser Ser Val 
    1520                 1525                 1530             


Glu Glu  Leu Leu Gly Ala Ile  Pro Gln Val Val Trp  Ile Lys Gly 
    1535                 1540                 1545             


His Gly  His Lys Arg Ile Val  Val Leu Lys Asn Asp  Met Lys Ser 
    1550                 1555                 1560             


Arg Leu  Ser Ser Leu Ser Leu  Ser Pro Ala Asn His  Glu Asn Gln 
    1565                 1570                 1575             


Pro Ser  Glu Gly Glu Arg Ile  Leu Glu Val Pro Glu  Ser His Thr 
    1580                 1585                 1590             


Ala Ser  Glu Leu Lys Leu Gly  Ala Asp Gly Ser Gly  Pro Ser His 
    1595                 1600                 1605             


Thr Glu  Gln Glu Leu Leu Arg  Leu Thr Asp Asp Ser  Pro Val Asp 
    1610                 1615                 1620             


Leu Leu  Cys Ala Pro Val Pro  Ser Cys Leu Pro Ser  Pro Gln Leu 
    1625                 1630                 1635             


Arg Pro  Asp Pro Val Ile Leu  Gln Ser Ala Asp Leu  Ile Gln Phe 
    1640                 1645                 1650             


Glu Glu  Arg Pro Gln Glu Pro  Ser Glu Ile Met Ile  Leu Asn Gln 
    1655                 1660                 1665             


Glu Glu  Lys Met Glu Ile Pro  Ile Pro Gly Lys Ser  Lys Thr Leu 
    1670                 1675                 1680             


Thr Ser  Asp Ser Ser Ser Ser  Cys Ile Ser Ala Ala  Val Pro Val 
    1685                 1690                 1695             


Pro Pro  Cys Pro Ser Ser Glu  Thr Ser Glu Ser Leu  Leu Ser Lys 
    1700                 1705                 1710             


Asp Pro  Val Glu Ser Pro Ala  Lys Lys Gln Pro Lys  Asn Arg Val 
    1715                 1720                 1725             


Lys Leu  Ala Ala Asn Phe Ser  Leu Ala Pro Ile Thr  Lys Leu 
    1730                 1735                 1740         


<210> 6946
<211> 276
<212> PRT
<213> Homo sapiens

<400> 6946
Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp Asp 
1               5                   10                  15      


Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala Tyr Tyr Thr Arg 
            20                  25                  30          


His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Arg Thr Arg Ser Leu Ser Gln Arg Gly Leu Gly Asn Cys Ser Ala Asn 
    50                  55                  60                  


Glu Ser Trp Thr Glu Val Ser Trp Pro Cys Arg Asn Ser Gln Ser Ser 
65                  70                  75                  80  


Glu Lys Ala Ile Asn Leu Gly Lys Lys Lys Ser Ser Trp Lys Ala Phe 
                85                  90                  95      


Phe Gly Val Val Glu Lys Glu Asp Ser Gln Ser Thr Pro Ala Lys Val 
            100                 105                 110         


Ser Ala Gln Gly Gln Arg Thr Leu Glu Tyr Gln Asp Ser His Ser Gln 
        115                 120                 125             


Gln Trp Ser Arg Cys Leu Ser Asn Val Glu Gln Cys Leu Glu His Glu 
    130                 135                 140                 


Ala Val Asp Pro Lys Val Ile Ser Ile Ala Asn Arg Val Ala Glu Ile 
145                 150                 155                 160 


Val Tyr Ser Trp Pro Pro Pro Gln Ala Thr Gln Ala Gly Gly Phe Lys 
                165                 170                 175     


Ser Lys Glu Ile Phe Val Thr Glu Gly Leu Ser Phe Gln Leu Gln Gly 
            180                 185                 190         


His Val Pro Val Ala Ser Ser Ser Lys Lys Asp Glu Glu Glu Gln Ile 
        195                 200                 205             


Leu Ala Lys Ile Val Glu Leu Leu Lys Tyr Ser Gly Asp Gln Leu Glu 
    210                 215                 220                 


Arg Lys Glu Lys Glu Trp Glu Glu Ser Ala Lys Thr Lys Ile Lys Met 
225                 230                 235                 240 


Ala Leu Leu Trp Arg Ser Ser Gly Gly Gly Pro Arg Val Leu Ser Ile 
                245                 250                 255     


Pro Glu Ala Phe Met Lys Asn Ser Phe Thr Leu Thr Pro Pro Gly Phe 
            260                 265                 270         


Ser Glu His Asn 
        275     


<210> 6947
<211> 183
<212> PRT
<213> Homo sapiens

<400> 6947
Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210> 6948
<211> 319
<212> PRT
<213> Homo sapiens

<400> 6948
Met Leu Arg Cys Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg 
1               5                   10                  15      


His Leu Gly Arg Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp 
            20                  25                  30          


Ser Tyr Phe Ser Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr 
        35                  40                  45              


Tyr Ser Ile His Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser 
    50                  55                  60                  


Ile Gly Gln Trp Tyr Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys 
65                  70                  75                  80  


Leu Ala Val Phe Asp Thr Trp Ser Ser Leu Ala Val His Ile Ala Met 
                85                  90                  95      


Asp Asn Thr Val Val Met Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser 
            100                 105                 110         


Val Pro Cys Ala Gly Ala Thr Ala Phe Pro Ala Asp Ser Asp Arg His 
        115                 120                 125             


Cys Asn Gly Phe Pro Ala Gly Ala Glu Val Thr Asn Arg Pro Ser Pro 
    130                 135                 140                 


Trp Arg Pro Leu Val Leu Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp 
145                 150                 155                 160 


Ile Asn Glu Ala Tyr Val Glu Thr Leu Lys His Cys Phe Met Met Pro 
                165                 170                 175     


Gln Ser Leu Gly Val Ile Gly Gly Lys Pro Asn Ser Ala His Tyr Phe 
            180                 185                 190         


Ile Gly Tyr Val Gly Glu Glu Leu Ile Tyr Leu Asp Pro His Thr Thr 
        195                 200                 205             


Gln Pro Ala Val Glu Pro Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser 
    210                 215                 220                 


Phe His Cys Gln His Pro Pro Cys Arg Met Ser Ile Ala Glu Leu Asp 
225                 230                 235                 240 


Pro Ser Ile Ala Val Gly Phe Phe Cys Lys Thr Glu Asp Asp Phe Asn 
                245                 250                 255     


Asp Trp Cys Gln Gln Val Lys Lys Leu Ser Leu Leu Gly Gly Ala Leu 
            260                 265                 270         


Pro Met Phe Glu Leu Val Glu Leu Gln Pro Ser His Leu Ala Cys Pro 
        275                 280                 285             


Asp Val Leu Asn Leu Ser Leu Asp Ser Ser Asp Val Glu Arg Leu Glu 
    290                 295                 300                 


Arg Phe Phe Asp Ser Glu Asp Glu Asp Phe Glu Ile Leu Ser Leu 
305                 310                 315                 


<210> 6949
<211> 187
<212> PRT
<213> Homo sapiens

<400> 6949
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Arg Asn Phe Ser 
            180                 185         


<210> 6950
<211> 89
<212> PRT
<213> Homo sapiens

<400> 6950
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 6951
<211> 89
<212> PRT
<213> Homo sapiens

<400> 6951
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 6952
<211> 490
<212> PRT
<213> Homo sapiens

<400> 6952
Met Glu Asp Ser Ala Ser Ala Ser Leu Ser Ser Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr Ser Thr Ser Thr Pro Ala Ala Pro Thr Ala Arg Lys Gln Leu Asp 
            20                  25                  30          


Lys Glu Gln Val Arg Lys Ala Val Asp Ala Leu Leu Thr His Cys Lys 
        35                  40                  45              


Ser Arg Lys Asn Asn Tyr Gly Leu Leu Leu Asn Glu Asn Glu Ser Leu 
    50                  55                  60                  


Phe Leu Met Val Val Leu Trp Lys Ile Pro Ser Lys Glu Leu Arg Val 
65                  70                  75                  80  


Arg Leu Thr Leu Pro His Ser Ile Arg Ser Asp Ser Glu Asp Ile Cys 
                85                  90                  95      


Leu Phe Thr Lys Asp Glu Pro Asn Ser Thr Pro Glu Lys Thr Glu Gln 
            100                 105                 110         


Phe Tyr Arg Lys Leu Leu Asn Lys His Gly Ile Lys Thr Val Ser Gln 
        115                 120                 125             


Ile Ile Ser Leu Gln Thr Leu Lys Lys Glu Tyr Lys Ser Tyr Glu Ala 
    130                 135                 140                 


Lys Leu Arg Leu Leu Ser Ser Phe Asp Phe Phe Leu Thr Asp Ala Arg 
145                 150                 155                 160 


Ile Arg Arg Leu Leu Pro Ser Leu Ile Gly Arg His Phe Tyr Gln Arg 
                165                 170                 175     


Lys Lys Val Pro Val Ser Val Asn Leu Leu Ser Lys Asn Leu Ser Arg 
            180                 185                 190         


Glu Ile Asn Asp Cys Ile Gly Gly Thr Val Leu Asn Ile Ser Lys Ser 
        195                 200                 205             


Gly Ser Cys Ser Ala Ile Arg Ile Gly His Val Gly Met Gln Ile Glu 
    210                 215                 220                 


His Ile Ile Glu Asn Ile Val Ala Val Thr Lys Gly Leu Ser Glu Lys 
225                 230                 235                 240 


Leu Pro Glu Lys Trp Glu Ser Val Lys Leu Leu Phe Val Lys Thr Glu 
                245                 250                 255     


Lys Ser Ala Ala Leu Pro Ile Phe Ser Ser Phe Val Ser Asn Trp Asp 
            260                 265                 270         


Glu Ala Thr Lys Arg Ser Leu Leu Asn Lys Lys Lys Lys Glu Ala Arg 
        275                 280                 285             


Arg Lys Arg Arg Glu Arg Asn Phe Glu Lys Gln Lys Glu Arg Lys Lys 
    290                 295                 300                 


Lys Arg Gln Gln Ala Arg Lys Thr Ala Ser Val Leu Ser Lys Asp Asp 
305                 310                 315                 320 


Val Ala Pro Glu Ser Gly Asp Thr Thr Val Lys Lys Pro Glu Ser Lys 
                325                 330                 335     


Lys Glu Gln Thr Pro Glu His Gly Lys Lys Lys Arg Gly Arg Gly Lys 
            340                 345                 350         


Ala Gln Val Lys Ala Thr Asn Glu Ser Glu Asp Glu Ile Pro Gln Leu 
        355                 360                 365             


Val Pro Ile Gly Lys Lys Thr Pro Ala Asn Glu Lys Val Glu Ile Gln 
    370                 375                 380                 


Lys His Ala Thr Gly Lys Lys Ser Pro Ala Lys Ser Pro Asn Pro Ser 
385                 390                 395                 400 


Thr Pro Arg Gly Lys Lys Arg Lys Ala Leu Pro Ala Ser Glu Thr Pro 
                405                 410                 415     


Lys Ala Ala Glu Ser Glu Thr Pro Gly Lys Ser Pro Glu Lys Lys Pro 
            420                 425                 430         


Lys Ile Lys Glu Glu Ala Val Lys Glu Lys Ser Pro Ser Leu Gly Lys 
        435                 440                 445             


Lys Asp Ala Arg Gln Thr Pro Lys Lys Pro Glu Ala Lys Phe Phe Thr 
    450                 455                 460                 


Thr Pro Ser Lys Ser Val Arg Lys Ala Ser His Thr Pro Lys Lys Trp 
465                 470                 475                 480 


Pro Lys Lys Pro Lys Val Pro Gln Ser Thr 
                485                 490 


<210> 6953
<211> 164
<212> PRT
<213> Homo sapiens

<400> 6953
Met Ala Glu Pro Ala Ser Val Ala Ala Glu Ser Leu Ala Gly Ser Arg 
1               5                   10                  15      


Ala Arg Ala Ala Arg Thr Val Leu Gly Gln Val Val Leu Pro Gly Glu 
            20                  25                  30          


Glu Leu Leu Leu Pro Glu Gln Glu Asp Ala Glu Gly Pro Gly Gly Ala 
        35                  40                  45              


Val Glu Arg Pro Leu Ser Leu Asn Ala Arg Ala Cys Ser Arg Val Arg 
    50                  55                  60                  


Val Val Cys Gly Pro Gly Leu Arg Arg Cys Gly Asp Arg Leu Leu Val 
65                  70                  75                  80  


Thr Lys Cys Gly Arg Leu Arg His Lys Glu Pro Gly Ser Gly Ser Gly 
                85                  90                  95      


Gly Gly Val Tyr Trp Val Asp Ser Gln Gln Lys Arg Tyr Val Pro Val 
            100                 105                 110         


Lys Gly Asp His Val Ile Gly Ile Val Thr Ala Lys Ser Gly Asp Ile 
        115                 120                 125             


Phe Lys Val Asp Val Gly Gly Ser Glu Pro Ala Ser Leu Ser Tyr Leu 
    130                 135                 140                 


Ser Phe Glu Gly Ala Thr Lys Arg Asn Arg Pro Asn Val Gln Ala Ile 
145                 150                 155                 160 


Ser Ser Arg Leu 
                


<210> 6954
<211> 835
<212> PRT
<213> Homo sapiens

<400> 6954
Met Thr Cys Asn Lys His Gly Cys Arg Gln Ala Phe His Val Thr Cys 
1               5                   10                  15      


Ala Gln Phe Ala Gly Leu Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp 
            20                  25                  30          


Asn Val Gln Tyr Cys Gly Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys 
        35                  40                  45              


Lys Ser Lys Arg Gly Ser Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp 
    50                  55                  60                  


Ser Ser Ser His Ser Gln Asp Lys His His Glu Lys Glu Lys Lys Lys 
65                  70                  75                  80  


Tyr Lys Glu Lys Asp Lys His Lys Gln Lys His Lys Lys Gln Pro Glu 
                85                  90                  95      


Pro Ser Pro Ala Leu Val Pro Ser Leu Thr Val Thr Thr Glu Lys Thr 
            100                 105                 110         


Tyr Thr Ser Thr Ser Asn Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu 
        115                 120                 125             


Glu Asp Thr Thr Ala Arg Phe Thr Asn Ala Asn Phe Gln Glu Val Ser 
    130                 135                 140                 


Ala His Thr Ser Ser Gly Lys Asp Val Ser Glu Thr Arg Gly Ser Glu 
145                 150                 155                 160 


Gly Lys Gly Lys Lys Ser Ser Ala His Ser Ser Gly Gln Arg Gly Arg 
                165                 170                 175     


Lys Pro Gly Gly Gly Arg Asn Pro Gly Thr Thr Val Ser Ala Ala Ser 
            180                 185                 190         


Pro Phe Pro Gln Gly Ser Phe Ser Gly Thr Pro Gly Ser Val Lys Ser 
        195                 200                 205             


Ser Ser Gly Ser Ser Val Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr 
    210                 215                 220                 


Asp Ser Asp Leu Arg Asn Asp Ser Tyr Ser His Ser Gln Gln Ser Ser 
225                 230                 235                 240 


Ala Thr Lys Asp Val His Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly 
                245                 250                 255     


Val Asn Ser Phe Ser Thr Leu Ile Gly Leu Pro Ser Thr Ser Ala Val 
            260                 265                 270         


Thr Ser Gln Pro Lys Ser Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn 
        275                 280                 285             


Ser Ser Leu Pro Thr Ala Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile 
    290                 295                 300                 


Glu Glu Glu Thr Val Lys Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser 
305                 310                 315                 320 


Lys His Gly Pro Gly Arg Pro Lys Gly Asn Lys Asn Gln Glu Asn Val 
                325                 330                 335     


Ser His Leu Ser Val Ser Ser Ala Ser Pro Thr Ser Ser Val Ala Ser 
            340                 345                 350         


Ala Ala Gly Ser Ile Thr Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu 
        355                 360                 365             


Leu Arg Asn Gly Ser Leu Gln Ser Leu Ser Val Gly Ser Ser Pro Val 
    370                 375                 380                 


Gly Ser Glu Ile Ser Met Gln Tyr Arg His Asp Gly Ala Cys Pro Thr 
385                 390                 395                 400 


Thr Ser Ile Tyr Asn Ser Asn Asp Val Ala Val Ser Phe Pro Asn Val 
                405                 410                 415     


Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser Ser Ser His Leu Pro 
            420                 425                 430         


Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly Ala Leu Ser Pro Ser 
        435                 440                 445             


Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr Thr Gln Ala Asn Thr 
    450                 455                 460                 


Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser His Met Tyr Gly Asn 
465                 470                 475                 480 


Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala Gln Ser Glu Asn Asn 
                485                 490                 495     


Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg Asn Leu Val Gly Arg 
            500                 505                 510         


Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg Ser Pro Val Ser Ser 
        515                 520                 525             


Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser Ser Leu Glu Asn Leu 
    530                 535                 540                 


Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu Glu Arg Gln Trp Ser 
545                 550                 555                 560 


Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr Pro Ser Asp Ile Leu 
                565                 570                 575     


Gly Met Leu Lys Ser Leu His Gln Leu Gln Val Glu Asn Arg Arg Leu 
            580                 585                 590         


Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys Glu Arg Leu Gln Leu 
        595                 600                 605             


Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr Ile Thr Ala Asn Pro 
    610                 615                 620                 


Ser Pro Ser His Gln Ile His Thr Phe Ser Ala Gln Thr Ala Pro Thr 
625                 630                 635                 640 


Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His Ile Gly Asn Ser Phe 
                645                 650                 655     


Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln Asp Leu Thr Ser Ser 
            660                 665                 670         


Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser Thr Pro Pro Pro Ala 
        675                 680                 685             


Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val Ser Gly Val Gln Gln 
    690                 695                 700                 


Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser Gly Met Gln Pro Val 
705                 710                 715                 720 


Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly Gly Ile Ile Gly Ala 
                725                 730                 735     


Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile Val Gly Ala Leu Asn 
            740                 745                 750         


Gly Val Met Gln Thr Pro Val Thr Met Ser Gln Asn Pro Thr Pro Leu 
        755                 760                 765             


Thr His Thr Thr Val Pro Pro Asn Ala Thr His Pro Met Pro Ala Thr 
    770                 775                 780                 


Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu Ser Asp Gln Gln Arg 
785                 790                 795                 800 


Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln Leu Leu Asn Ser Gln 
                805                 810                 815     


Gln Leu Thr Pro Asn Met Val Lys Glu Phe Ser Ala Gln Ile Ile Ala 
            820                 825                 830         


Trp Arg Pro 
        835 


<210> 6955
<211> 539
<212> PRT
<213> Homo sapiens

<400> 6955
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 6956
<211> 147
<212> PRT
<213> Homo sapiens

<400> 6956
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Thr His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Thr Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Thr Arg Arg Thr 
        35                  40                  45              


Arg Thr Phe Ser Ala Thr Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Thr 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Asp Val Glu 
                85                  90                  95      


Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Thr Tyr Lys Met Cys 
            100                 105                 110         


Ser Ile Pro Pro Lys Asn Glu Lys Leu Gln Ala Val Glu Val Val Ile 
        115                 120                 125             


Thr His Leu Ala Pro Gly Thr Lys His Glu Thr Trp Ser Gly His Val 
    130                 135                 140                 


Ile Ser Ser 
145         


<210> 6957
<211> 316
<212> PRT
<213> Homo sapiens

<400> 6957
Met Thr Pro Ser Glu Gly Ala Arg Ala Gly Thr Gly Arg Glu Leu Glu 
1               5                   10                  15      


Met Leu Asp Ser Leu Leu Ala Leu Gly Gly Leu Val Leu Leu Arg Asp 
            20                  25                  30          


Ser Val Glu Trp Glu Gly Arg Ser Leu Leu Lys Ala Leu Val Lys Lys 
        35                  40                  45              


Ser Ala Leu Cys Gly Glu Gln Val His Ile Leu Gly Cys Glu Val Ser 
    50                  55                  60                  


Glu Glu Glu Phe Arg Glu Gly Phe Asp Ser Asp Ile Asn Asn Arg Leu 
65                  70                  75                  80  


Val Tyr His Asp Phe Phe Arg Asp Pro Leu Asn Trp Ser Lys Thr Glu 
                85                  90                  95      


Glu Ala Phe Pro Gly Gly Pro Leu Gly Ala Leu Arg Ala Met Cys Lys 
            100                 105                 110         


Arg Thr Asp Pro Val Pro Val Thr Ile Ala Leu Asp Ser Leu Ser Trp 
        115                 120                 125             


Leu Leu Leu Arg Leu Pro Cys Thr Thr Leu Cys Gln Val Leu His Ala 
    130                 135                 140                 


Val Ser His Gln Asp Ser Cys Pro Gly Asp Ser Ser Ser Val Gly Lys 
145                 150                 155                 160 


Val Ser Val Leu Gly Leu Leu His Glu Glu Leu His Gly Pro Gly Pro 
                165                 170                 175     


Val Gly Ala Leu Ser Ser Leu Ala Gln Thr Glu Val Thr Leu Gly Gly 
            180                 185                 190         


Thr Met Gly Gln Ala Ser Ala His Ile Leu Cys Arg Arg Pro Arg Gln 
        195                 200                 205             


Arg Pro Thr Asp Gln Thr Gln Trp Phe Ser Ile Leu Pro Asp Phe Ser 
    210                 215                 220                 


Leu Asp Leu Gln Glu Gly Pro Ser Val Glu Ser Gln Pro Tyr Ser Asp 
225                 230                 235                 240 


Pro His Ile Pro Pro Val Asp Pro Thr Thr His Leu Thr Phe Asn Leu 
                245                 250                 255     


His Leu Ser Lys Lys Glu Arg Glu Ala Arg Asp Ser Leu Ile Leu Pro 
            260                 265                 270         


Phe Gln Phe Ser Ser Glu Lys Gln Gln Ala Leu Leu Arg Pro Arg Pro 
        275                 280                 285             


Gly Gln Ala Thr Ser His Ile Phe Tyr Glu Pro Asp Ala Tyr Asp Asp 
    290                 295                 300                 


Leu Asp Gln Glu Asp Pro Asp Asp Asp Leu Asp Ile 
305                 310                 315     


<210> 6958
<211> 316
<212> PRT
<213> Homo sapiens

<400> 6958
Met Thr Pro Ser Glu Gly Ala Arg Ala Gly Thr Gly Arg Glu Leu Glu 
1               5                   10                  15      


Met Leu Asp Ser Leu Leu Ala Leu Gly Gly Leu Val Leu Leu Arg Asp 
            20                  25                  30          


Ser Val Glu Trp Glu Gly Arg Ser Leu Leu Lys Ala Leu Val Lys Lys 
        35                  40                  45              


Ser Ala Leu Cys Gly Glu Gln Val His Ile Leu Gly Cys Glu Val Ser 
    50                  55                  60                  


Glu Glu Glu Phe Arg Glu Gly Phe Asp Ser Asp Ile Asn Asn Arg Leu 
65                  70                  75                  80  


Val Tyr His Asp Phe Phe Arg Asp Pro Leu Asn Trp Ser Lys Thr Glu 
                85                  90                  95      


Glu Ala Phe Pro Gly Gly Pro Leu Gly Ala Leu Arg Ala Met Cys Lys 
            100                 105                 110         


Arg Thr Asp Pro Val Pro Val Thr Ile Ala Leu Asp Ser Leu Ser Trp 
        115                 120                 125             


Leu Leu Leu Arg Leu Pro Cys Thr Thr Leu Cys Gln Val Leu His Ala 
    130                 135                 140                 


Val Ser His Gln Asp Ser Cys Pro Gly Asp Ser Ser Ser Val Gly Lys 
145                 150                 155                 160 


Val Ser Val Leu Gly Leu Leu His Glu Glu Leu His Gly Pro Gly Pro 
                165                 170                 175     


Val Gly Ala Leu Ser Ser Leu Ala Gln Thr Glu Val Thr Leu Gly Gly 
            180                 185                 190         


Thr Met Gly Gln Ala Ser Ala His Ile Leu Cys Arg Arg Pro Arg Gln 
        195                 200                 205             


Arg Pro Thr Asp Gln Thr Gln Trp Phe Ser Ile Leu Pro Asp Phe Ser 
    210                 215                 220                 


Leu Asp Leu Gln Glu Gly Pro Ser Val Glu Ser Gln Pro Tyr Ser Asp 
225                 230                 235                 240 


Pro His Ile Pro Pro Val Asp Pro Thr Thr His Leu Thr Phe Asn Leu 
                245                 250                 255     


His Leu Ser Lys Lys Glu Arg Glu Ala Arg Asp Ser Leu Ile Leu Pro 
            260                 265                 270         


Phe Gln Phe Ser Ser Glu Lys Gln Gln Ala Leu Leu Arg Pro Arg Pro 
        275                 280                 285             


Gly Gln Ala Thr Ser His Ile Phe Tyr Glu Pro Asp Ala Tyr Asp Asp 
    290                 295                 300                 


Leu Asp Gln Glu Asp Pro Asp Asp Asp Leu Asp Ile 
305                 310                 315     


<210> 6959
<211> 269
<212> PRT
<213> Homo sapiens

<400> 6959
Met Asn Gln Glu Asp Leu Asp Pro Asp Ser Thr Thr Asp Val Gly Asp 
1               5                   10                  15      


Val Thr Asn Thr Glu Glu Glu Leu Ile Arg Glu Cys Glu Glu Met Trp 
            20                  25                  30          


Lys Asp Met Glu Glu Cys Gln Asn Lys Leu Ser Leu Ile Gly Thr Glu 
        35                  40                  45              


Thr Leu Thr Asp Ser Asn Ala Gln Leu Ser Leu Leu Ile Met Gln Val 
    50                  55                  60                  


Lys Cys Leu Thr Ala Glu Leu Ser Gln Trp Gln Lys Lys Thr Pro Glu 
65                  70                  75                  80  


Thr Ile Pro Leu Thr Glu Asp Val Leu Ile Thr Leu Gly Lys Glu Glu 
                85                  90                  95      


Phe Gln Lys Leu Arg Gln Asp Leu Glu Met Val Leu Ser Thr Lys Glu 
            100                 105                 110         


Ser Lys Asn Glu Lys Leu Lys Glu Asp Leu Glu Arg Glu Gln Arg Trp 
        115                 120                 125             


Leu Asp Glu Gln Gln Gln Ile Met Glu Ser Leu Asn Val Leu His Ser 
    130                 135                 140                 


Glu Leu Lys Asn Lys Val Glu Thr Phe Ser Glu Ser Arg Ile Phe Asn 
145                 150                 155                 160 


Glu Leu Lys Thr Lys Met Leu Asn Ile Lys Glu Tyr Lys Glu Lys Leu 
                165                 170                 175     


Leu Ser Thr Leu Gly Glu Phe Leu Glu Asp His Phe Pro Leu Pro Asp 
            180                 185                 190         


Arg Ser Val Lys Lys Lys Lys Lys Asn Ile Gln Glu Ser Ser Val Asn 
        195                 200                 205             


Leu Ile Thr Leu His Glu Met Leu Glu Ile Leu Ile Asn Arg Leu Phe 
    210                 215                 220                 


Asp Val Pro His Asp Pro Tyr Val Lys Ile Ser Asp Ser Phe Trp Pro 
225                 230                 235                 240 


Pro Tyr Val Glu Leu Leu Leu Arg Asn Gly Ile Ala Leu Arg His Pro 
                245                 250                 255     


Glu Asp Pro Thr Arg Ile Arg Leu Glu Ala Phe His Gln 
            260                 265                 


<210> 6960
<211> 390
<212> PRT
<213> Homo sapiens

<400> 6960
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


Leu Asn Cys Val Met Lys Lys His Lys Glu Leu Ser Ser Leu Gln Lys 
        115                 120                 125             


Ile Pro Ser Gln Gln Arg Lys Lys Ile Ser Ser Gly Lys Ser Glu Pro 
    130                 135                 140                 


Pro Leu Gly Asn Glu Lys Ile Ser Ala Glu Ala Val Gly Val Asp Ile 
145                 150                 155                 160 


Ser Gly Arg Phe Met Thr Ser Gly Lys Lys Lys Ala Val Val Ile Arg 
                165                 170                 175     


His Leu Tyr Asn Glu Asp Asn Val Asp Ile Ser Glu Asp Thr Leu Ser 
            180                 185                 190         


Pro Ile Thr Asp Val Asn Glu Ala Val Asp Val Ser Asp Leu Asn Ala 
        195                 200                 205             


Thr Glu Ile Lys Met Pro Glu Val Lys Val Pro Glu Ile Lys Ala Glu 
    210                 215                 220                 


Gln Gln Asp Val Asn Val Asn Pro Glu Ile Thr Ala Leu Gln Thr Met 
225                 230                 235                 240 


Leu Ala Glu Cys Gln Glu Asn Leu Lys Lys Leu Thr Ser Ile Glu Lys 
                245                 250                 255     


Arg Leu Asp Cys Leu Glu Gln Lys Met Lys Gly Lys Val Met Val Asp 
            260                 265                 270         


Glu Asn Thr Trp Thr Asn Leu Leu Ser Arg Val Thr Leu Leu Glu Thr 
        275                 280                 285             


Glu Met Leu Leu Ser Lys Lys Asn Asp Glu Phe Ile Glu Phe Asn Glu 
    290                 295                 300                 


Val Ser Glu Asp Tyr Ala Ser Cys Ser Asp Met Asp Leu Leu Asn Pro 
305                 310                 315                 320 


His Arg Lys Ser Glu Val Glu Arg Pro Ala Ser Ile Pro Leu Ser Ser 
                325                 330                 335     


Gly Tyr Ser Thr Ala Ser Ser Asp Ser Thr Pro Arg Ala Ser Thr Val 
            340                 345                 350         


Asn Tyr Cys Gly Leu Asn Glu Ile Ser Glu Glu Thr Thr Ile Gln Lys 
        355                 360                 365             


Met Glu Arg Met Lys Lys Met Phe Glu Glu Thr Ala Glu Leu Leu Lys 
    370                 375                 380                 


Cys Pro Asn His Tyr Leu 
385                 390 


<210> 6961
<211> 126
<212> PRT
<213> Homo sapiens

<400> 6961
Met Pro Phe Phe Gly Asn Thr Phe Ser Pro Lys Lys Thr Pro Pro Arg 
1               5                   10                  15      


Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Thr Arg 
            20                  25                  30          


Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Thr Met Asn Leu Ala 
        35                  40                  45              


Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala Glu Thr Gly 
    50                  55                  60                  


Val Ser Gly Gly Val Asp Arg Arg Glu Val Gln Arg Leu Arg Arg Arg 
65                  70                  75                  80  


Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp 
                85                  90                  95      


Ile Leu Leu Asp Met Leu Ser Glu Ser Thr Ala Glu Ser His Leu Met 
            100                 105                 110         


Glu Lys Glu Leu Asp Glu Leu Arg Ile Ser Arg Lys Arg Lys 
        115                 120                 125     


<210> 6962
<211> 236
<212> PRT
<213> Homo sapiens

<400> 6962
Met Gln Val Gln Asp Asp Gly Val Asn Leu Ile Pro Phe Ala Lys Cys 
1               5                   10                  15      


Ser Arg Val Val Ser Arg Ser Pro Pro Pro Arg Leu Pro Ser Gln Ser 
            20                  25                  30          


Leu Arg Pro Met Pro Gln Arg Tyr Gly Asp Val Phe Trp Lys Asn Leu 
        35                  40                  45              


Asn Gln Arg Pro Thr Pro Thr Trp Leu Glu Glu Gln His Ile Pro Pro 
    50                  55                  60                  


Met Leu Arg Ala Thr Gly Cys Ser Gln Leu Gly Leu Tyr Pro Pro Glu 
65                  70                  75                  80  


Gln Leu Pro Pro Pro Glu Met Leu Trp Arg Arg Lys Lys Arg Arg Pro 
                85                  90                  95      


Cys Leu Glu Gly Met Gln Gln Gln Gly Leu Gly Gly Val Pro Ala Arg 
            100                 105                 110         


Val Arg Ala Val Thr Tyr His Leu Glu Asp Leu Arg Arg Arg Gln Ser 
        115                 120                 125             


Ile Ile Asn Glu Leu Lys Lys Ala Gln Trp Gly Ser Ser Gly Ala Ala 
    130                 135                 140                 


Ser Glu Pro Val Val Leu Gly Glu Glu Gly Cys Gly Phe Pro Ser Thr 
145                 150                 155                 160 


Asn Glu Tyr Pro Asp Leu Glu Glu Glu Arg Ala Thr Tyr Pro Gln Glu 
                165                 170                 175     


Glu Asp Arg Phe Leu Thr Pro Gly Arg Ala Gln Leu Leu Trp Ser Pro 
            180                 185                 190         


Trp Ser Pro Leu Asp Gln Glu Glu Ala Cys Ala Ser Arg Gln Leu His 
        195                 200                 205             


Ser Leu Ala Ser Phe Ser Thr Val Thr Ala Arg Arg Asn Pro Leu His 
    210                 215                 220                 


Asn Pro Trp Gly Met Glu Leu Ala Ala Ser Glu Glu 
225                 230                 235     


<210> 6963
<211> 559
<212> PRT
<213> Homo sapiens

<400> 6963
Met Asn Pro Leu Phe Gly Pro Asn Leu Phe Leu Leu Gln Gln Glu Gln 
1               5                   10                  15      


Gln Gly Leu Ala Gly Pro Leu Gly Asp Ser Leu Gly Gly Asp His Phe 
            20                  25                  30          


Ala Gly Gly Gly Asp Leu Pro Pro Ala Pro Leu Ser Pro Ala Gly Pro 
        35                  40                  45              


Ala Ala Tyr Ser Pro Pro Gly Pro Gly Pro Ala Pro Pro Ala Ala Met 
    50                  55                  60                  


Ala Leu Arg Asn Asp Leu Gly Ser Asn Ile Asn Val Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Leu Arg Phe Arg Cys Phe Leu Ala Lys Val His Glu Leu Glu Arg 
                85                  90                  95      


Arg Asn Arg Leu Leu Glu Lys Gln Leu Gln Gln Ala Leu Glu Glu Gly 
            100                 105                 110         


Lys Gln Gly Arg Arg Gly Leu Gly Arg Arg Asp Gln Ala Val Gln Thr 
        115                 120                 125             


Gly Phe Val Ser Pro Ile Arg Pro Leu Gly Leu Gln Leu Gly Ala Arg 
    130                 135                 140                 


Pro Ala Ala Val Cys Ser Pro Ser Ala Arg Val Leu Gly Ser Pro Ala 
145                 150                 155                 160 


Arg Ser Pro Ala Gly Pro Leu Ala Pro Ser Ala Ala Ser Leu Ser Ser 
                165                 170                 175     


Ser Ser Thr Ser Thr Ser Thr Thr Tyr Ser Ser Ser Ala Arg Phe Met 
            180                 185                 190         


Pro Gly Thr Ile Trp Ser Phe Ser His Ala Arg Arg Leu Gly Pro Gly 
        195                 200                 205             


Leu Glu Pro Thr Leu Val Gln Gly Pro Gly Leu Ser Trp Val His Pro 
    210                 215                 220                 


Asp Gly Val Gly Val Gln Ile Asp Thr Ile Thr Pro Glu Ile Arg Ala 
225                 230                 235                 240 


Leu Tyr Asn Val Leu Ala Lys Val Lys Arg Glu Arg Asp Glu Tyr Lys 
                245                 250                 255     


Arg Arg Trp Glu Glu Glu Tyr Thr Val Arg Ile Gln Leu Gln Asp Arg 
            260                 265                 270         


Val Asn Glu Leu Gln Glu Glu Ala Gln Glu Ala Asp Ala Cys Gln Glu 
        275                 280                 285             


Glu Leu Ala Leu Lys Val Glu Gln Leu Lys Ala Glu Leu Val Val Phe 
    290                 295                 300                 


Lys Gly Leu Met Ser Asn Asn Leu Ser Glu Leu Asp Thr Lys Ile Gln 
305                 310                 315                 320 


Glu Lys Ala Met Lys Val Asp Met Asp Ile Cys Arg Arg Ile Asp Ile 
                325                 330                 335     


Thr Ala Lys Leu Cys Asp Val Ala Gln Gln Arg Asn Cys Glu Asp Met 
            340                 345                 350         


Ile Gln Met Phe Gln Val Pro Ser Met Gly Gly Arg Lys Arg Glu Arg 
        355                 360                 365             


Lys Ala Ala Val Glu Glu Asp Thr Ser Leu Ser Glu Ser Glu Gly Pro 
    370                 375                 380                 


Arg Gln Pro Asp Gly Asp Glu Glu Glu Ser Thr Ala Leu Ser Ile Asn 
385                 390                 395                 400 


Glu Glu Met Gln Arg Met Leu Asn Gln Leu Arg Glu Tyr Asp Phe Glu 
                405                 410                 415     


Asp Asp Cys Asp Ser Leu Thr Trp Glu Glu Thr Glu Glu Thr Leu Leu 
            420                 425                 430         


Leu Trp Glu Asp Phe Ser Gly Tyr Ala Met Ala Ala Ala Glu Ala Gln 
        435                 440                 445             


Gly Glu Gln Glu Asp Ser Leu Glu Lys Val Ile Lys Asp Thr Glu Ser 
    450                 455                 460                 


Leu Phe Lys Thr Arg Glu Lys Glu Tyr Gln Glu Thr Ile Asp Gln Ile 
465                 470                 475                 480 


Glu Leu Glu Leu Ala Thr Ala Lys Asn Asp Met Asn Arg His Leu His 
                485                 490                 495     


Glu Tyr Met Glu Met Cys Ser Met Lys Arg Gly Leu Asp Val Gln Met 
            500                 505                 510         


Glu Thr Cys Arg Arg Leu Ile Thr Gln Ser Gly Asp Arg Lys Ser Pro 
        515                 520                 525             


Ala Phe Thr Ala Val Pro Leu Ser Asp Pro Pro Pro Pro Pro Ser Glu 
    530                 535                 540                 


Ala Glu Asp Ser Asp Arg Asp Val Ser Ser Asp Ser Ser Met Arg 
545                 550                 555                 


<210> 6964
<211> 393
<212> PRT
<213> Homo sapiens

<400> 6964
Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val 
1               5                   10                  15      


Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp 
            20                  25                  30          


Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln 
        35                  40                  45              


Asp Phe Arg Glu Asp Gln Asp Ala Ala Phe Phe Lys Ala Trp Ala Ile 
    50                  55                  60                  


Phe Lys Gly Lys Tyr Lys Glu Gly Asp Thr Gly Gly Pro Ala Val Trp 
65                  70                  75                  80  


Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu 
                85                  90                  95      


Val Pro Glu Arg Gly Arg Met Asp Val Ala Glu Pro Tyr Lys Val Tyr 
            100                 105                 110         


Gln Leu Leu Pro Pro Gly Ile Val Ser Gly Gln Pro Gly Thr Gln Lys 
        115                 120                 125             


Val Pro Ser Lys Arg Gln His Ser Ser Val Ser Ser Glu Arg Lys Glu 
    130                 135                 140                 


Glu Glu Asp Ala Met Gln Asn Cys Thr Leu Ser Pro Ser Val Leu Gln 
145                 150                 155                 160 


Asp Ser Leu Asn Asn Glu Glu Glu Gly Ala Ser Gly Gly Ala Val His 
                165                 170                 175     


Ser Asp Ile Gly Ser Ser Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu 
            180                 185                 190         


Val Thr Asp Thr Thr Glu Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu 
        195                 200                 205             


Glu Phe Leu Leu Pro Pro Glu Pro Asp Tyr Ser Leu Leu Leu Thr Phe 
    210                 215                 220                 


Ile Tyr Asn Gly Arg Val Val Gly Glu Ala Gln Val Gln Ser Leu Asp 
225                 230                 235                 240 


Cys Arg Leu Val Ala Glu Pro Ser Gly Ser Glu Ser Ser Met Glu Gln 
                245                 250                 255     


Val Leu Phe Pro Lys Pro Gly Pro Leu Glu Pro Thr Gln Arg Leu Leu 
            260                 265                 270         


Ser Gln Leu Glu Arg Gly Ile Leu Val Ala Ser Asn Pro Arg Gly Leu 
        275                 280                 285             


Phe Val Gln Arg Leu Cys Pro Ile Pro Ile Ser Trp Asn Ala Pro Gln 
    290                 295                 300                 


Ala Pro Pro Gly Pro Gly Pro His Leu Leu Pro Ser Asn Glu Cys Val 
305                 310                 315                 320 


Glu Leu Phe Arg Thr Ala Tyr Phe Cys Arg Asp Leu Val Arg Tyr Phe 
                325                 330                 335     


Gln Gly Leu Gly Pro Pro Pro Lys Phe Gln Val Thr Leu Asn Phe Trp 
            340                 345                 350         


Glu Glu Ser His Gly Ser Ser His Thr Pro Gln Asn Leu Ile Thr Val 
        355                 360                 365             


Lys Met Glu Gln Ala Phe Ala Arg Tyr Leu Leu Glu Gln Thr Pro Glu 
    370                 375                 380                 


Gln Gln Ala Ala Ile Leu Ser Leu Val 
385                 390             


<210> 6965
<211> 817
<212> PRT
<213> Homo sapiens

<400> 6965
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Gln Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu 
    


<210> 6966
<211> 138
<212> PRT
<213> Homo sapiens

<400> 6966
Met Ile Leu Gln Gln Pro Leu Gln Arg Gly Pro Gln Gly Gly Ala Gln 
1               5                   10                  15      


Arg Leu Pro Arg Ala Ala Leu Gly Val Thr Trp Gly Leu Asp Ala Ser 
            20                  25                  30          


Ser Pro Leu Arg Gly Ala Val Pro Met Ser Thr Lys Arg Arg Leu Glu 
        35                  40                  45              


Glu Glu Gln Glu Pro Leu Arg Lys Gln Phe Leu Ser Glu Glu Asn Met 
    50                  55                  60                  


Ala Thr His Phe Ser Gln Leu Ser Leu His Asn Asp His Pro Tyr Cys 
65                  70                  75                  80  


Ser Pro Pro Met Thr Phe Ser Pro Ala Leu Pro Pro Leu Arg Ser Pro 
                85                  90                  95      


Cys Ser Glu Leu Leu Leu Trp Arg Tyr Pro Gly Ser Leu Ile Pro Glu 
            100                 105                 110         


Ala Leu Arg Leu Leu Arg Leu Gly Asp Thr Pro Ser Pro Pro Tyr Pro 
        115                 120                 125             


Ala Thr Pro Ala Gly Asp Ile Met Glu Leu 
    130                 135             


<210> 6967
<211> 1433
<212> PRT
<213> Homo sapiens

<400> 6967
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Cys Tyr Leu Arg Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His 
            820                 825                 830         


Val Arg Thr Arg Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu 
        835                 840                 845             


Leu Ser Val Phe Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala 
    850                 855                 860                 


Gln Trp Gln Arg Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn 
865                 870                 875                 880 


Tyr Met Thr Gln Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp 
                885                 890                 895     


Pro Leu Ser Glu Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly 
            900                 905                 910         


Val Lys Gly Val Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe 
        915                 920                 925             


Arg Pro Ala Ser Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser 
    930                 935                 940                 


Met Glu Asn Leu Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala 
945                 950                 955                 960 


Leu Gln Thr Ser Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg 
                965                 970                 975     


Ser Pro Leu Ile Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser 
            980                 985                 990         


Glu Thr Ser Ser Ser Arg Pro Gly  Gly Tyr Arg Leu Phe  Ser Ser Ser 
        995                 1000                 1005             


Arg Pro  Pro Thr Glu Met Lys  Gln Ser Gly Leu Gly  Ser Gln Cys 
    1010                 1015                 1020             


Thr Gly  Leu Phe Ser Thr Thr  Val Leu Gly Gly Ser  Ser Ser Ala 
    1025                 1030                 1035             


Pro Asn  Leu Gln Asp Tyr Ala  Arg Ser His Gly Lys  Lys Leu Pro 
    1040                 1045                 1050             


Pro Ala  Ser Leu Lys His Arg  Asp Glu Leu Leu Phe  Val Pro Ala 
    1055                 1060                 1065             


Val Lys  Arg Phe Ser Val Ser  Phe Ala Lys His Pro  Thr Asn Gly 
    1070                 1075                 1080             


Phe Glu  Gly Cys Ser Met Val  Pro Thr Ile Tyr Pro  Leu Glu Thr 
    1085                 1090                 1095             


Leu His  Asn Ala Leu Ser Leu  Arg Gln Val Ser Glu  Phe Leu Ser 
    1100                 1105                 1110             


Arg Val  Cys Gln Arg His Thr  Asp Ala Gln Ala Gln  Ala Ser Ala 
    1115                 1120                 1125             


Ala Leu  Phe Asp Ser Met His  Ser Ser Gln Ala Ser  Asp Asn Pro 
    1130                 1135                 1140             


Phe Ser  Pro Pro Arg Thr Leu  His Ser Pro Pro Leu  Gln Leu Gln 
    1145                 1150                 1155             


Gln Arg  Ser Glu Lys Pro Pro  Trp Tyr Ser Ser Gly  Pro Ser Ser 
    1160                 1165                 1170             


Thr Val  Ser Ser Ala Gly Pro  Ser Ser Pro Thr Thr  Val Asp Gly 
    1175                 1180                 1185             


Asn Ser  Gln Phe Gly Phe Ser  Asp Gln Pro Ser Leu  Asn Ser His 
    1190                 1195                 1200             


Val Ala  Glu Glu His Gln Gly  Leu Gly Leu Leu Gln  Glu Thr Pro 
    1205                 1210                 1215             


Gly Ser  Gly Ala Gln Glu Leu  Ser Ile Glu Gly Glu  Gln Glu Leu 
    1220                 1225                 1230             


Phe Glu  Pro Asn Gln Ser Pro  Gln Val Pro Pro Met  Glu Thr Ser 
    1235                 1240                 1245             


Gln Pro  Tyr Glu Glu Val Ser  Gln Pro Cys Gln Glu  Val Pro Asp 
    1250                 1255                 1260             


Ile Ser  Gln Pro Cys Gln Asp  Ile Ser Glu Ala Leu  Ser Gln Pro 
    1265                 1270                 1275             


Cys Gln  Lys Val Pro Asp Ile  Ser Gln Gln Cys Gln  Glu Asn His 
    1280                 1285                 1290             


Asp Asn  Gly Asn His Thr Cys  Gln Glu Val Pro His  Ile Ser Gln 
    1295                 1300                 1305             


Pro Cys  Gln Lys Ser Ser Gln  Leu Cys Gln Lys Val  Ser Glu Glu 
    1310                 1315                 1320             


Val Cys  Gln Leu Cys Leu Glu  Asn Ser Glu Glu Val  Ser Gln Pro 
    1325                 1330                 1335             


Cys Gln  Gly Val Ser Val Glu  Val Gly Lys Leu Val  His Lys Phe 
    1340                 1345                 1350             


His Val  Gly Val Gly Ser Leu  Val Gln Glu Thr Leu  Val Glu Val 
    1355                 1360                 1365             


Gly Ser  Pro Ala Glu Glu Ile  Pro Glu Glu Val Ile  Gln Pro Tyr 
    1370                 1375                 1380             


Gln Glu  Phe Ser Val Glu Val  Gly Arg Leu Ala Gln  Glu Thr Ser 
    1385                 1390                 1395             


Ala Ile  Asn Leu Leu Ser Gln  Gly Ile Pro Glu Ile  Asp Lys Pro 
    1400                 1405                 1410             


Ser Gln  Glu Phe Pro Glu Glu  Ile Asp Leu Gln Ala  Gln Glu Val 
    1415                 1420                 1425             


Pro Glu  Glu Ile Asn 
    1430             


<210> 6968
<211> 144
<212> PRT
<213> Homo sapiens

<400> 6968
Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly Arg Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Arg Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Thr 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr His Phe Arg Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Arg Thr Val Arg Gly Met Leu Pro His Lys Thr Lys Arg Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Arg Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
            100                 105                 110         


Gly Asn Arg Pro Arg Arg Thr Trp Arg Arg Lys Leu Thr Asn Thr Gln 
        115                 120                 125             


Arg Ser Ser Arg Pro Thr Asp Ser Trp Ser Glu Pro Asn Lys Asp Cys 
    130                 135                 140                 


<210> 6969
<211> 135
<212> PRT
<213> Homo sapiens

<400> 6969
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210> 6970
<211> 135
<212> PRT
<213> Homo sapiens

<400> 6970
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210> 6971
<211> 227
<212> PRT
<213> Homo sapiens

<400> 6971
Met Glu Pro Gln Gly Tyr Pro Ala Phe Gly Trp Asp His Ser Leu His 
1               5                   10                  15      


Lys Arg Lys Arg Leu Pro Pro Val Lys Arg Ser Leu Val Tyr Tyr Leu 
            20                  25                  30          


Lys Asn Arg Glu Val Arg Leu Gln Asn Glu Thr Ser Tyr Ser Arg Val 
        35                  40                  45              


Leu His Gly Tyr Ala Ala Gln Gln Leu Pro Ser Leu Leu Lys Glu Arg 
    50                  55                  60                  


Glu Phe His Leu Gly Thr Leu Asn Lys Val Phe Ala Ser Gln Trp Leu 
65                  70                  75                  80  


Asn His Arg Gln Val Val Cys Gly Thr Lys Cys Asn Thr Leu Phe Val 
                85                  90                  95      


Val Asp Val Gln Thr Ser Gln Ile Thr Lys Ile Pro Ile Leu Lys Asp 
            100                 105                 110         


Arg Glu Pro Gly Gly Val Thr Gln Gln Gly Cys Gly Ile His Ala Ile 
        115                 120                 125             


Glu Leu Asn Pro Ser Arg Thr Leu Leu Ala Thr Gly Gly Asp Asn Pro 
    130                 135                 140                 


Asn Ser Leu Ala Ile Tyr Arg Leu Pro Thr Leu Asp Pro Val Cys Val 
145                 150                 155                 160 


Gly Asp Asp Gly His Lys Asp Trp Ile Phe Ser Ile Ala Trp Ile Ser 
                165                 170                 175     


Asp Thr Met Ala Val Ser Gly Ser Arg Asp Gly Ser Met Gly Leu Trp 
            180                 185                 190         


Glu Val Thr Asp Asp Val Leu Thr Lys Ser Asp Ala Arg His Asn Val 
        195                 200                 205             


Ser Arg Val Pro Val Tyr Ala His Ile Thr His Lys Ala Leu Lys Asp 
    210                 215                 220                 


Ile Pro Lys 
225         


<210> 6972
<211> 517
<212> PRT
<213> Homo sapiens

<400> 6972
Met Thr Arg Leu Gly Thr Val Pro Arg Lys Ala Leu Glu Met Ser Cys 
1               5                   10                  15      


Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu Ala Glu Phe Glu Met Thr 
            20                  25                  30          


Leu Glu Arg Asp Val Leu Gln Pro Leu Ser Arg Leu Ser Glu Glu Glu 
        35                  40                  45              


Leu Pro Ala Ile Leu Lys His Lys Lys Ser Leu Gln Lys Leu Val Ser 
    50                  55                  60                  


Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser Gln Ala Thr Lys Asn Ser 
65                  70                  75                  80  


Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro Gly Ser His Ser His Thr 
                85                  90                  95      


Thr Met Ala Asn Lys Val Glu Thr Leu Lys Glu Glu Glu Glu Glu Leu 
            100                 105                 110         


Lys Arg Lys Val Glu Gln Cys Arg Asp Glu Tyr Leu Ala Asp Leu Tyr 
        115                 120                 125             


His Phe Val Thr Lys Glu Asp Ser Tyr Ala Asn Tyr Phe Ile Arg Leu 
    130                 135                 140                 


Leu Glu Ile Gln Ala Asp Tyr His Arg Arg Ser Leu Ser Ser Leu Asp 
145                 150                 155                 160 


Thr Ala Leu Ala Glu Leu Arg Glu Asn His Gly Gln Ala Asp His Ser 
                165                 170                 175     


Pro Ser Met Thr Ala Thr His Phe Pro Arg Val Tyr Gly Val Ser Leu 
            180                 185                 190         


Ala Thr His Leu Gln Glu Leu Gly Arg Glu Ile Ala Leu Pro Ile Glu 
        195                 200                 205             


Ala Cys Val Met Met Leu Leu Ser Glu Gly Met Lys Glu Glu Gly Leu 
    210                 215                 220                 


Phe Arg Leu Ala Ala Gly Ala Ser Val Leu Lys Arg Leu Lys Gln Thr 
225                 230                 235                 240 


Met Ala Ser Asp Pro His Ser Leu Glu Glu Phe Cys Ser Asp Pro His 
                245                 250                 255     


Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro 
            260                 265                 270         


Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp Met Arg Ala Ala Ser Leu 
        275                 280                 285             


Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu Gln Glu Val Cys Ser Arg 
    290                 295                 300                 


Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg Tyr Leu Met Lys Phe Leu 
305                 310                 315                 320 


Ala Arg Leu Ala Glu Glu Gln Glu Val Asn Lys Met Thr Pro Ser Asn 
                325                 330                 335     


Ile Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Pro Glu Lys Glu 
            340                 345                 350         


Gly Asp Gln Ala Gln Leu Asp Ala Ala Ser Val Ser Ser Ile Gln Val 
        355                 360                 365             


Val Gly Val Val Glu Ala Leu Ile Gln Ser Ala Asp Thr Leu Phe Pro 
    370                 375                 380                 


Gly Asp Ile Asn Phe Asn Val Ser Gly Leu Phe Ser Ala Val Thr Leu 
385                 390                 395                 400 


Gln Asp Thr Val Ser Asp Arg Leu Ala Ser Glu Glu Leu Pro Ser Thr 
                405                 410                 415     


Ala Val Pro Thr Pro Ala Thr Thr Pro Ala Pro Ala Pro Ala Pro Ala 
            420                 425                 430         


Pro Ala Pro Ala Pro Ala Leu Ala Ser Ala Ala Thr Lys Glu Arg Thr 
        435                 440                 445             


Glu Ser Glu Val Pro Pro Arg Pro Ala Ser Pro Lys Val Thr Arg Ser 
    450                 455                 460                 


Pro Pro Glu Thr Ala Ala Pro Val Glu Asp Met Ala Arg Arg Ser Pro 
465                 470                 475                 480 


Arg Gly Ala Thr Gly Arg Lys Glu Arg Phe Ala Cys Ser Tyr Gly Thr 
                485                 490                 495     


Asp Ser Ser Leu Ala Asp Met Phe Phe Val Arg Leu Val Asn Lys Leu 
            500                 505                 510         


Phe Trp Thr Lys Leu 
        515         


<210> 6973
<211> 305
<212> PRT
<213> Homo sapiens

<400> 6973
Met Asp Leu Ser Gly Val Lys Lys Lys Ser Leu Leu Gly Val Lys Glu 
1               5                   10                  15      


Asn Asn Lys Lys Ser Ser Thr Arg Ala Pro Ser Pro Thr Lys Arg Lys 
            20                  25                  30          


Asp Arg Ser Asp Glu Lys Ser Lys Asp Arg Ser Lys Asp Lys Gly Ala 
        35                  40                  45              


Thr Lys Glu Ser Ser Glu Lys Asp Arg Gly Arg Asp Lys Thr Arg Lys 
    50                  55                  60                  


Arg Arg Ser Ala Ser Ser Gly Ser Ser Ser Thr Arg Ser Arg Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Gly Ser Ser Thr Ser Thr Gly Ser Ser Ser Gly 
                85                  90                  95      


Ser Ser Ser Ser Ser Ala Ser Ser Arg Ser Gly Ser Ser Ser Thr Ser 
            100                 105                 110         


Arg Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Pro Ser Pro Ser Arg 
        115                 120                 125             


Arg Arg His Asp Asn Arg Arg Arg Ser Arg Ser Lys Ser Lys Pro Pro 
    130                 135                 140                 


Lys Arg Asp Glu Lys Glu Arg Lys Arg Arg Ser Pro Ser Pro Lys Pro 
145                 150                 155                 160 


Thr Lys Val His Ile Gly Arg Leu Thr Arg Asn Val Thr Lys Asp His 
                165                 170                 175     


Ile Met Glu Ile Phe Ser Thr Tyr Gly Lys Ile Lys Met Ile Asp Met 
            180                 185                 190         


Pro Val Glu Arg Met His Pro His Leu Ser Lys Gly Tyr Ala Tyr Val 
        195                 200                 205             


Glu Phe Glu Asn Pro Asp Glu Ala Glu Lys Ala Leu Lys His Met Asp 
    210                 215                 220                 


Gly Gly Gln Ile Asp Gly Gln Glu Ile Thr Ala Thr Ala Val Leu Ala 
225                 230                 235                 240 


Pro Trp Pro Arg Pro Pro Pro Arg Arg Phe Ser Pro Pro Arg Arg Met 
                245                 250                 255     


Leu Pro Pro Pro Pro Met Trp Arg Arg Ser Pro Pro Arg Met Arg Arg 
            260                 265                 270         


Arg Ser Arg Ser Pro Arg Arg Arg Ser Pro Val Arg Arg Arg Ser Arg 
        275                 280                 285             


Ser Pro Gly Arg Arg Arg His Arg Ser Arg Ser Ser Ser Asn Ser Ser 
    290                 295                 300                 


Arg 
305 


<210> 6974
<211> 308
<212> PRT
<213> Homo sapiens

<400> 6974
Met Ile His Asp Ala Gln Met Asp Tyr Tyr Gly Thr Arg Leu Ala Thr 
1               5                   10                  15      


Cys Ser Ser Asp Arg Ser Val Lys Ile Phe Asp Val Arg Asn Gly Gly 
            20                  25                  30          


Gln Ile Leu Ile Ala Asp Leu Arg Gly His Glu Gly Pro Val Trp Gln 
        35                  40                  45              


Val Ala Trp Ala His Pro Met Tyr Gly Asn Ile Leu Ala Ser Cys Ser 
    50                  55                  60                  


Tyr Asp Arg Lys Val Ile Ile Trp Arg Glu Glu Asn Gly Thr Trp Glu 
65                  70                  75                  80  


Lys Ser His Glu His Ala Gly His Asp Ser Ser Val Asn Ser Val Cys 
                85                  90                  95      


Trp Ala Pro His Asp Tyr Gly Leu Ile Leu Ala Cys Gly Ser Ser Asp 
            100                 105                 110         


Gly Ala Ile Ser Leu Leu Thr Tyr Thr Gly Glu Gly Gln Trp Glu Val 
        115                 120                 125             


Lys Lys Ile Asn Asn Ala His Thr Ile Gly Cys Asn Ala Val Ser Trp 
    130                 135                 140                 


Ala Pro Ala Val Val Pro Gly Ser Leu Ile Asp His Pro Ser Gly Gln 
145                 150                 155                 160 


Lys Pro Asn Tyr Ile Lys Arg Phe Ala Ser Gly Gly Cys Asp Asn Leu 
                165                 170                 175     


Ile Lys Leu Trp Lys Glu Glu Glu Asp Gly Gln Trp Lys Glu Glu Gln 
            180                 185                 190         


Lys Leu Glu Ala His Ser Asp Trp Val Arg Asp Val Ala Trp Ala Pro 
        195                 200                 205             


Ser Ile Gly Leu Pro Thr Ser Thr Ile Ala Ser Cys Ser Gln Asp Gly 
    210                 215                 220                 


Arg Val Phe Ile Trp Thr Cys Asp Asp Ala Ser Ser Asn Thr Trp Ser 
225                 230                 235                 240 


Pro Lys Leu Leu His Lys Phe Asn Asp Val Val Trp His Val Ser Trp 
                245                 250                 255     


Ser Ile Thr Ala Asn Ile Leu Ala Val Ser Gly Gly Asp Asn Lys Val 
            260                 265                 270         


Thr Leu Trp Lys Glu Ser Val Asp Gly Gln Trp Val Cys Ile Ser Asp 
        275                 280                 285             


Val Asn Lys Gly Gln Gly Ser Val Ser Ala Ser Val Thr Glu Gly Gln 
    290                 295                 300                 


Gln Asn Glu Gln 
305             


<210> 6975
<211> 513
<212> PRT
<213> Homo sapiens

<400> 6975
Met Ser Ile Glu Ile Glu Ser Ser Asp Val Ile Arg Leu Ile Met Gln 
1               5                   10                  15      


Tyr Leu Lys Glu Asn Ser Leu His Arg Ala Leu Ala Thr Leu Gln Glu 
            20                  25                  30          


Glu Thr Thr Val Ser Leu Asn Thr Val Asp Ser Ile Glu Ser Phe Val 
        35                  40                  45              


Ala Asp Ile Asn Ser Gly His Trp Asp Thr Val Leu Gln Ala Ile Gln 
    50                  55                  60                  


Ser Leu Lys Leu Pro Asp Lys Thr Leu Ile Asp Leu Tyr Glu Gln Val 
65                  70                  75                  80  


Val Leu Glu Leu Ile Glu Leu Arg Glu Leu Gly Ala Ala Arg Ser Leu 
                85                  90                  95      


Leu Arg Gln Thr Asp Pro Met Ile Met Leu Lys Gln Thr Gln Pro Glu 
            100                 105                 110         


Arg Tyr Ile His Leu Glu Asn Leu Leu Ala Arg Ser Tyr Phe Asp Pro 
        115                 120                 125             


Arg Glu Ala Tyr Pro Asp Gly Ser Ser Lys Glu Lys Arg Arg Ala Ala 
    130                 135                 140                 


Ile Ala Gln Ala Leu Ala Gly Glu Val Ser Val Val Pro Pro Ser Arg 
145                 150                 155                 160 


Leu Met Ala Leu Leu Gly Gln Ala Leu Lys Trp Gln Gln His Gln Gly 
                165                 170                 175     


Leu Leu Pro Pro Gly Met Thr Ile Asp Leu Phe Arg Gly Lys Ala Ala 
            180                 185                 190         


Val Lys Asp Val Glu Glu Glu Lys Phe Pro Thr Gln Leu Ser Arg His 
        195                 200                 205             


Ile Lys Phe Gly Gln Lys Ser His Val Glu Cys Ala Arg Phe Ser Pro 
    210                 215                 220                 


Asp Gly Gln Tyr Leu Val Thr Gly Ser Val Asp Gly Phe Ile Glu Val 
225                 230                 235                 240 


Trp Asn Phe Thr Thr Gly Lys Ile Arg Lys Asp Leu Lys Tyr Gln Ala 
                245                 250                 255     


Gln Asp Asn Phe Met Met Met Asp Asp Ala Val Leu Cys Met Cys Phe 
            260                 265                 270         


Ser Arg Asp Thr Glu Met Leu Ala Thr Gly Ala Gln Asp Gly Lys Ile 
        275                 280                 285             


Lys Val Trp Lys Ile Gln Ser Gly Gln Cys Leu Arg Arg Phe Glu Arg 
    290                 295                 300                 


Ala His Ser Lys Gly Val Thr Cys Leu Ser Phe Ser Lys Asp Ser Ser 
305                 310                 315                 320 


Gln Ile Leu Ser Ala Ser Phe Asp Gln Thr Ile Arg Ile His Gly Leu 
                325                 330                 335     


Lys Ser Gly Lys Thr Leu Lys Glu Phe Arg Gly His Ser Ser Phe Val 
            340                 345                 350         


Asn Glu Ala Thr Phe Thr Gln Asp Gly His Tyr Ile Ile Ser Ala Ser 
        355                 360                 365             


Ser Asp Gly Thr Val Lys Ile Trp Asn Met Lys Thr Thr Glu Cys Ser 
    370                 375                 380                 


Asn Thr Phe Lys Ser Leu Gly Ser Thr Ala Gly Thr Asp Ile Thr Val 
385                 390                 395                 400 


Asn Ser Val Ile Leu Leu Pro Lys Asn Pro Glu His Phe Val Val Cys 
                405                 410                 415     


Asn Arg Ser Asn Thr Val Val Ile Met Asn Met Gln Gly Gln Ile Val 
            420                 425                 430         


Arg Ser Phe Ser Ser Gly Lys Arg Glu Gly Gly Asp Phe Val Cys Cys 
        435                 440                 445             


Ala Leu Ser Pro Arg Gly Glu Trp Ile Tyr Cys Val Gly Glu Asp Phe 
    450                 455                 460                 


Val Leu Tyr Cys Phe Ser Thr Val Thr Gly Lys Leu Glu Arg Thr Leu 
465                 470                 475                 480 


Thr Val His Glu Lys Asp Val Ile Gly Ile Ala His His Pro His Gln 
                485                 490                 495     


Asn Leu Ile Ala Thr Tyr Ser Glu Asp Gly Leu Leu Lys Leu Trp Lys 
            500                 505                 510         


Pro 
    


<210> 6976
<211> 711
<212> PRT
<213> Homo sapiens

<400> 6976
Met Ser Ser Val Gln Ser Gln Gln Glu Gln Leu Ser Gln Ser Asp Pro 
1               5                   10                  15      


Ser Pro Ser Pro Asn Ser Cys Ser Ser Phe Glu Leu Ile Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Leu Tyr Glu Pro Val Ser Pro His Trp Phe Tyr Cys Lys 
        35                  40                  45              


Ile Ile Asp Ser Lys Glu Thr Trp Ile Pro Phe Asn Ser Glu Asp Ser 
    50                  55                  60                  


Gln Gln Leu Glu Glu Ala Tyr Ser Ser Gly Lys Gly Cys Asn Gly Arg 
65                  70                  75                  80  


Val Val Pro Thr Asp Gly Gly Arg Tyr Asp Val His Leu Gly Glu Arg 
                85                  90                  95      


Met Arg Tyr Ala Val Tyr Trp Asp Glu Leu Ala Ser Glu Val Arg Arg 
            100                 105                 110         


Cys Thr Trp Phe Tyr Lys Gly Asp Lys Asp Asn Lys Tyr Val Pro Tyr 
        115                 120                 125             


Ser Glu Ser Phe Ser Gln Val Leu Glu Glu Thr Tyr Met Leu Ala Val 
    130                 135                 140                 


Thr Leu Asp Glu Trp Lys Lys Lys Leu Glu Ser Pro Asn Arg Glu Ile 
145                 150                 155                 160 


Ile Ile Leu His Asn Pro Lys Leu Met Val His Tyr Gln Pro Val Ala 
                165                 170                 175     


Gly Ser Asp Asp Trp Gly Ser Thr Pro Thr Glu Gln Gly Arg Pro Arg 
            180                 185                 190         


Thr Val Lys Arg Gly Val Glu Asn Ile Ser Val Asp Ile His Cys Gly 
        195                 200                 205             


Glu Pro Leu Gln Ile Asp His Leu Val Phe Val Val His Gly Ile Gly 
    210                 215                 220                 


Pro Ala Cys Asp Leu Arg Phe Arg Ser Ile Val Gln Cys Val Asn Asp 
225                 230                 235                 240 


Phe Arg Ser Val Ser Leu Asn Leu Leu Gln Thr His Phe Lys Lys Ala 
                245                 250                 255     


Gln Glu Asn Gln Gln Ile Gly Arg Val Glu Phe Leu Pro Val Asn Trp 
            260                 265                 270         


His Ser Pro Leu His Ser Thr Gly Val Asp Val Asp Leu Gln Arg Ile 
        275                 280                 285             


Thr Leu Pro Ser Ile Asn Arg Leu Arg His Phe Thr Asn Asp Thr Ile 
    290                 295                 300                 


Leu Asp Val Phe Phe Tyr Asn Ser Pro Thr Tyr Cys Gln Thr Ile Val 
305                 310                 315                 320 


Asp Thr Val Ala Ser Glu Met Asn Arg Ile Tyr Thr Leu Phe Leu Gln 
                325                 330                 335     


Arg Asn Pro Asp Phe Lys Gly Gly Val Ser Ile Ala Gly His Ser Leu 
            340                 345                 350         


Gly Ser Leu Ile Leu Phe Asp Ile Leu Thr Asn Gln Lys Asp Ser Leu 
        355                 360                 365             


Gly Asp Ile Asp Ser Glu Lys Asp Ser Leu Asn Ile Val Met Asp Gln 
    370                 375                 380                 


Gly Asp Thr Pro Thr Leu Glu Glu Asp Leu Lys Lys Leu Gln Leu Ser 
385                 390                 395                 400 


Glu Phe Phe Asp Ile Phe Glu Lys Glu Lys Val Asp Lys Glu Ala Leu 
                405                 410                 415     


Ala Leu Cys Thr Asp Arg Asp Leu Gln Glu Ile Gly Ile Pro Leu Gly 
            420                 425                 430         


Pro Arg Lys Lys Ile Leu Asn Tyr Phe Ser Thr Arg Lys Asn Ser Met 
        435                 440                 445             


Gly Ile Lys Arg Pro Ala Pro Gln Pro Ala Ser Gly Ala Asn Ile Pro 
    450                 455                 460                 


Lys Glu Ser Glu Phe Cys Ser Ser Ser Asn Thr Arg Asn Gly Asp Tyr 
465                 470                 475                 480 


Leu Asp Val Gly Ile Gly Gln Val Ser Val Lys Tyr Pro Arg Leu Ile 
                485                 490                 495     


Tyr Lys Pro Glu Ile Phe Phe Ala Phe Gly Ser Pro Ile Gly Met Phe 
            500                 505                 510         


Leu Thr Val Arg Gly Leu Lys Arg Ile Asp Pro Asn Tyr Arg Phe Pro 
        515                 520                 525             


Thr Cys Lys Gly Phe Phe Asn Ile Tyr His Pro Phe Asp Pro Val Ala 
    530                 535                 540                 


Tyr Arg Ile Glu Pro Met Val Val Pro Gly Val Glu Phe Glu Pro Met 
545                 550                 555                 560 


Leu Ile Pro His His Lys Gly Arg Lys Arg Met His Leu Glu Leu Arg 
                565                 570                 575     


Glu Gly Leu Thr Arg Met Ser Met Asp Leu Lys Asn Asn Leu Leu Gly 
            580                 585                 590         


Ser Leu Arg Met Ala Trp Lys Ser Phe Thr Arg Ala Pro Tyr Pro Ala 
        595                 600                 605             


Leu Gln Ala Ser Glu Thr Pro Glu Glu Thr Glu Ala Glu Pro Glu Ser 
    610                 615                 620                 


Thr Ser Glu Lys Pro Ser Asp Val Asn Thr Glu Glu Thr Ser Val Ala 
625                 630                 635                 640 


Val Lys Glu Glu Val Leu Pro Ile Asn Val Gly Met Leu Asn Gly Gly 
                645                 650                 655     


Gln Arg Ile Asp Tyr Val Leu Gln Glu Lys Pro Ile Glu Ser Phe Asn 
            660                 665                 670         


Glu Tyr Leu Phe Ala Leu Gln Ser His Leu Cys Tyr Trp Glu Ser Glu 
        675                 680                 685             


Asp Thr Val Leu Leu Val Leu Lys Glu Ile Tyr Gln Thr Gln Gly Ile 
    690                 695                 700                 


Phe Leu Asp Gln Pro Leu Gln 
705                 710     


<210> 6977
<211> 1116
<212> PRT
<213> Homo sapiens

<400> 6977
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Val Glu Gln Leu Lys Glu Glu Leu Ser 
        435                 440                 445             


Ser Lys Glu Ala Gln Trp Glu Glu Leu Lys Lys Lys Ala Ala Gly Leu 
    450                 455                 460                 


Gln Ala Glu Ile Gly Gln Val Lys Gln Glu Leu Ser Arg Lys Asp Thr 
465                 470                 475                 480 


Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu Thr Asn Gln Phe 
                485                 490                 495     


Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu Ser Leu Thr Ala 
            500                 505                 510         


Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val Asp Ala Leu Arg 
        515                 520                 525             


Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys Lys Thr Lys Gln 
    530                 535                 540                 


Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala Gly Glu Ile His 
545                 550                 555                 560 


Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys Val Asn Val Leu 
                565                 570                 575     


Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg Asp Lys Glu Lys 
            580                 585                 590         


Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu Gln Ala Asp Thr 
        595                 600                 605             


Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu Ala Leu Ala Glu 
    610                 615                 620                 


Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg Asp Arg Asp Glu 
625                 630                 635                 640 


Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys Asp Leu Lys Asp 
                645                 650                 655     


Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu Ser Glu Lys Glu 
            660                 665                 670         


Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser Leu Ala Ser Ser 
        675                 680                 685             


Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu Ile Ala Leu Glu 
    690                 695                 700                 


Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln Leu Lys Lys Ala 
705                 710                 715                 720 


His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu Met Ser Asp Arg 
                725                 730                 735     


Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys Asp Glu Ser Ser 
            740                 745                 750         


Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile Leu Lys Glu Val 
        755                 760                 765             


Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala Glu Leu Glu Arg 
    770                 775                 780                 


Gln Val Lys Asp Gln Asn Lys Lys Val Ala Asn Leu Lys His Lys Glu 
785                 790                 795                 800 


Gln Val Glu Lys Lys Lys Ser Ala Gln Met Leu Glu Glu Ala Arg Arg 
                805                 810                 815     


Arg Glu Asp Asn Leu Asn Asp Ser Ser Gln Gln Leu Gln Asp Ser Leu 
            820                 825                 830         


Arg Lys Lys Asp Asp Arg Ile Glu Glu Leu Glu Glu Ala Leu Arg Glu 
        835                 840                 845             


Ser Val Gln Ile Thr Ala Glu Arg Glu Met Val Leu Ala Gln Glu Glu 
    850                 855                 860                 


Ser Ala Arg Thr Asn Ala Glu Lys Gln Val Glu Glu Leu Leu Met Ala 
865                 870                 875                 880 


Met Glu Lys Val Lys Gln Glu Leu Glu Ser Met Lys Ala Lys Leu Ser 
                885                 890                 895     


Ser Thr Gln Gln Ser Leu Ala Glu Lys Glu Thr His Leu Thr Asn Leu 
            900                 905                 910         


Arg Ala Glu Arg Arg Lys His Leu Glu Glu Val Leu Glu Met Lys Gln 
        915                 920                 925             


Glu Ala Leu Leu Ala Ala Ile Ser Glu Lys Asp Ala Asn Ile Ala Leu 
    930                 935                 940                 


Leu Glu Leu Ser Ser Ser Lys Lys Lys Thr Gln Glu Glu Val Ala Ala 
945                 950                 955                 960 


Leu Lys Arg Glu Lys Asp Arg Leu Val Gln Gln Leu Lys Gln Gln Thr 
                965                 970                 975     


Gln Asn Arg Met Lys Leu Met Ala Asp Asn Tyr Glu Asp Asp His Phe 
            980                 985                 990         


Lys Ser Ser His Ser Asn Gln Thr  Asn His Lys Pro Ser  Pro Asp Gln 
        995                 1000                 1005             


Ile Ile  Gln Pro Leu Leu Glu  Leu Asp Gln Asn Arg  Ser Lys Leu 
    1010                 1015                 1020             


Lys Leu  Tyr Ile Gly His Leu  Thr Thr Leu Cys His  Asp Arg Asp 
    1025                 1030                 1035             


Pro Leu  Ile Leu Arg Gly Leu  Thr Pro Pro Ala Ser  Tyr Asn Leu 
    1040                 1045                 1050             


Asp Asp  Asp Gln Ala Ala Trp  Glu Asn Glu Leu Gln  Lys Met Thr 
    1055                 1060                 1065             


Arg Gly  Gln Leu Gln Asp Glu  Leu Glu Lys Gly Glu  Arg Asp Asn 
    1070                 1075                 1080             


Ala Glu  Leu Gln Glu Phe Ala  Asn Ala Ile Leu Gln  Gln Ile Ala 
    1085                 1090                 1095             


Asp His  Cys Pro Asp Ile Leu  Glu Gln Val Val Asn  Ala Leu Glu 
    1100                 1105                 1110             


Glu Ser  Ser 
    1115     


<210> 6978
<211> 410
<212> PRT
<213> Homo sapiens

<400> 6978
Met Gln Asn Ile His Gly Lys Glu Ile Asp Leu Leu Arg Thr Thr Val 
1               5                   10                  15      


Lys Val Pro Gly Lys Arg Leu Pro Arg Ala Thr Pro Ala Thr Ala Pro 
            20                  25                  30          


Gly Thr Ser Pro Arg Ala Asn Gly Leu Ser Val Glu Arg Ser Asn Thr 
        35                  40                  45              


Gln Leu Gly Gly Gly Thr Ala Ser Gly Pro Ala Glu Val Leu Ser Ser 
    50                  55                  60                  


Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ser Asn Arg Lys Lys 
65                  70                  75                  80  


His Arg Arg Lys Lys Ser Thr Gly Thr Pro Arg Pro Asp Gly Pro Ser 
                85                  90                  95      


Ser Ala Thr Glu Glu Ala Glu Glu Ser Phe Glu Phe Val Val Val Ser 
            100                 105                 110         


Leu Thr Gly Gln Thr Trp His Phe Glu Ala Ser Thr Ala Glu Glu Arg 
        115                 120                 125             


Glu Leu Trp Val Gln Ser Val Gln Ala Gln Ile Leu Ala Ser Leu Gln 
    130                 135                 140                 


Gly Cys Arg Ser Ala Lys Asp Lys Thr Arg Leu Gly Asn Gln Asn Ala 
145                 150                 155                 160 


Ala Leu Ala Val Gln Ala Val Arg Thr Val Arg Gly Asn Ser Phe Cys 
                165                 170                 175     


Ile Asp Cys Asp Ala Pro Asn Pro Asp Trp Ala Ser Leu Asn Leu Gly 
            180                 185                 190         


Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg His Leu Gly Ala 
        195                 200                 205             


His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Pro Glu 
    210                 215                 220                 


Leu Leu Ala Val Met Thr Ala Met Gly Asn Ala Leu Ala Asn Ser Val 
225                 230                 235                 240 


Trp Glu Gly Ala Leu Gly Gly Tyr Ser Lys Pro Gly Pro Asp Ala Cys 
                245                 250                 255     


Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu 
            260                 265                 270         


Phe Leu Ala Pro Leu Pro Ser Ser Asp Val Pro Leu Gly Gln Gln Leu 
        275                 280                 285             


Leu Arg Ala Val Val Glu Asp Asp Leu Arg Leu Leu Val Met Leu Leu 
    290                 295                 300                 


Ala His Gly Ser Lys Glu Glu Val Asn Glu Thr Tyr Gly Asp Gly Asp 
305                 310                 315                 320 


Gly Arg Thr Ala Leu His Leu Ser Ser Ala Met Ala Asn Val Val Phe 
                325                 330                 335     


Thr Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Arg Ser Arg Asp Ala 
            340                 345                 350         


Arg Gly Leu Thr Pro Leu Ala Tyr Ala Arg Arg Ala Gly Ser Gln Glu 
        355                 360                 365             


Cys Ala Asp Ile Leu Ile Gln His Gly Cys Pro Gly Glu Gly Cys Gly 
    370                 375                 380                 


Leu Ala Pro Thr Pro Asn Arg Glu Pro Ala Asn Gly Thr Asn Pro Ser 
385                 390                 395                 400 


Ala Glu Leu His Arg Ser Pro Ser Leu Leu 
                405                 410 


<210> 6979
<211> 163
<212> PRT
<213> Homo sapiens

<400> 6979
Met Ser Asp Ser Pro Ala Gly Ser Asn Pro Arg Thr Pro Glu Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Gly Gly Gly Lys Arg Pro Ala Val Pro Ala Ala 
            20                  25                  30          


Val Ser Leu Leu Pro Pro Ala Asp Pro Leu Arg Gln Ala Asn Arg Leu 
        35                  40                  45              


Pro Ile Arg Val Leu Lys Met Leu Ser Ala His Thr Gly His Leu Leu 
    50                  55                  60                  


His Pro Glu Tyr Leu Gln Pro Leu Ser Ser Thr Pro Val Ser Pro Ile 
65                  70                  75                  80  


Glu Leu Asp Ala Lys Lys Ser Pro Leu Ala Leu Leu Ala Gln Thr Cys 
                85                  90                  95      


Ser Gln Ile Gly Ser Pro Gly Ser Leu Ser Leu Arg Asn Pro His Thr 
            100                 105                 110         


Leu Gly Leu Ser Arg Tyr His Pro Tyr Gly Lys Ser His Leu Ser Thr 
        115                 120                 125             


Ala Gly Gly Leu Ala Val Pro Ser Leu Pro Thr Ala Gly Pro Tyr Tyr 
    130                 135                 140                 


Ser Pro Tyr Ala Leu Tyr Gly Gln Arg Leu Ala Ser Ala Ser Ala Leu 
145                 150                 155                 160 


Gly Tyr Gln 
            


<210> 6980
<211> 911
<212> PRT
<213> Homo sapiens

<400> 6980
Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Ser 
1               5                   10                  15      


Leu Ala Ala Pro Gly Gly Gly Gly Ala Ala Ala Gln Gln Leu Val Cys 
            20                  25                  30          


Gly Gly Gln Phe Gly Gly Ala Gly Pro Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Ser Gln Gln Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His 
65                  70                  75                  80  


Pro Asn Ile Tyr Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu 
                85                  90                  95      


Ala Leu Gln Asn Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser 
            100                 105                 110         


Phe Val Asn Ser Gln Glu Trp Thr Leu Ser Arg Ser Val Pro Glu Leu 
        115                 120                 125             


Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val 
    130                 135                 140                 


His Arg Tyr Leu Thr Gly Thr Tyr Val Gln Glu Glu Ser Pro Glu Gly 
145                 150                 155                 160 


Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu 
                165                 170                 175     


Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp 
            180                 185                 190         


Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe 
        195                 200                 205             


Gln Thr Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala 
    210                 215                 220                 


Ser Glu Val Pro Met Val Leu Val Gly Thr Gln Asp Ala Ile Ser Ala 
225                 230                 235                 240 


Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Thr 
                245                 250                 255     


Asp Leu Lys Arg Cys Thr Tyr Tyr Glu Thr Cys Ala Thr Tyr Gly Leu 
            260                 265                 270         


Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu 
        275                 280                 285             


Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn 
    290                 295                 300                 


Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His 
305                 310                 315                 320 


Ile Asn Gln Ala Thr Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser 
                325                 330                 335     


Ser Ser Val Pro Ser Thr Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile 
            340                 345                 350         


Glu Thr Ile Ala Ala Ser Ser Thr Pro Thr Pro Ile Arg Lys Gln Ser 
        355                 360                 365             


Lys Arg Arg Ser Asn Ile Phe Thr Ser Arg Lys Gly Ala Asp Leu Asp 
    370                 375                 380                 


Arg Glu Lys Lys Ala Ala Glu Cys Lys Val Asp Ser Ile Gly Ser Gly 
385                 390                 395                 400 


Arg Ala Ile Pro Ile Lys Gln Gly Ile Leu Leu Lys Arg Ser Gly Lys 
                405                 410                 415     


Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Thr Leu Cys Asp Asn 
            420                 425                 430         


Gly Leu Leu Thr Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Ile 
        435                 440                 445             


His Gly Lys Glu Ile Asp Leu Leu Arg Thr Thr Val Lys Val Pro Gly 
    450                 455                 460                 


Lys Arg Leu Pro Arg Ala Thr Pro Ala Thr Ala Pro Gly Thr Ser Pro 
465                 470                 475                 480 


Arg Ala Asn Gly Leu Ser Val Glu Arg Ser Asn Thr Gln Leu Gly Gly 
                485                 490                 495     


Gly Thr Gly Ala Pro His Ser Ala Ser Ser Ala Ser Leu His Ser Glu 
            500                 505                 510         


Arg Pro Leu Ser Ser Ser Ala Trp Ala Gly Pro Arg Pro Glu Gly Leu 
        515                 520                 525             


His Gln Arg Ser Cys Ser Val Ser Ser Ala Asp Gln Trp Ser Glu Ala 
    530                 535                 540                 


Thr Thr Ser Leu Pro Pro Gly Met Gln His Pro Ala Ser Gly Pro Ala 
545                 550                 555                 560 


Glu Val Leu Ser Ser Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His 
                565                 570                 575     


Ser Asn Arg Lys Lys His Arg Arg Lys Lys Ser Thr Gly Thr Pro Arg 
            580                 585                 590         


Pro Asp Gly Pro Ser Ser Ala Thr Glu Glu Ala Glu Glu Ser Phe Glu 
        595                 600                 605             


Phe Val Val Val Ser Leu Thr Gly Gln Thr Trp His Phe Glu Ala Ser 
    610                 615                 620                 


Thr Ala Glu Glu Arg Glu Leu Trp Val Gln Ser Val Gln Ala Gln Ile 
625                 630                 635                 640 


Leu Ala Ser Leu Gln Gly Cys Arg Ser Ala Lys Asp Lys Thr Arg Leu 
                645                 650                 655     


Gly Asn Gln Asn Ala Ala Leu Ala Val Gln Ala Val Arg Thr Val Arg 
            660                 665                 670         


Gly Asn Ser Phe Cys Ile Asp Cys Asp Ala Pro Asn Pro Asp Trp Ala 
        675                 680                 685             


Ser Leu Asn Leu Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His 
    690                 695                 700                 


Arg His Leu Gly Ala His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp 
705                 710                 715                 720 


Asp Trp Pro Pro Glu Leu Leu Ala Val Met Thr Ala Met Gly Asn Ala 
                725                 730                 735     


Leu Ala Asn Ser Val Trp Glu Gly Ala Leu Gly Gly Tyr Ser Lys Pro 
            740                 745                 750         


Gly Pro Asp Ala Cys Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys 
        755                 760                 765             


Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro Ser Ser Asp Val Pro 
    770                 775                 780                 


Leu Gly Gln Gln Leu Leu Arg Ala Val Val Glu Asp Asp Leu Arg Leu 
785                 790                 795                 800 


Leu Val Met Leu Leu Ala His Gly Ser Lys Glu Glu Val Asn Glu Thr 
                805                 810                 815     


Tyr Gly Asp Gly Asp Gly Arg Thr Ala Leu His Leu Ser Ser Ala Met 
            820                 825                 830         


Ala Asn Val Val Phe Thr Gln Leu Leu Ile Trp Tyr Gly Val Asp Val 
        835                 840                 845             


Arg Ser Arg Asp Ala Arg Gly Leu Thr Pro Leu Ala Tyr Ala Arg Arg 
    850                 855                 860                 


Ala Gly Ser Gln Glu Cys Ala Asp Ile Leu Ile Gln His Gly Cys Pro 
865                 870                 875                 880 


Gly Glu Gly Cys Gly Leu Ala Pro Thr Pro Asn Arg Glu Pro Ala Asn 
                885                 890                 895     


Gly Thr Asn Pro Ser Ala Glu Leu His Arg Ser Pro Ser Leu Leu 
            900                 905                 910     


<210> 6981
<211> 352
<212> PRT
<213> Homo sapiens

<400> 6981
Met Asp Ile Asp Lys Asp Leu Glu Ala Pro Leu Tyr Leu Thr Pro Glu 
1               5                   10                  15      


Gly Trp Ser Leu Phe Leu Gln Arg Tyr Tyr Gln Val Val His Glu Gly 
            20                  25                  30          


Ala Glu Leu Arg His Leu Asp Thr Gln Val Gln Arg Cys Glu Asp Ile 
        35                  40                  45              


Leu Gln Gln Leu Gln Ala Val Val Pro Gln Ile Asp Met Glu Gly Asp 
    50                  55                  60                  


Arg Asn Ile Trp Ile Val Lys Pro Gly Ala Lys Ser Arg Gly Arg Gly 
65                  70                  75                  80  


Ile Met Cys Met Asp His Leu Glu Glu Met Leu Lys Leu Val Asn Gly 
                85                  90                  95      


Asn Pro Val Val Met Lys Asp Gly Lys Trp Val Val Gln Lys Tyr Ile 
            100                 105                 110         


Glu Arg Pro Leu Leu Ile Phe Gly Thr Lys Phe Asp Leu Arg Gln Trp 
        115                 120                 125             


Phe Leu Val Thr Asp Trp Asn Pro Leu Thr Val Trp Phe Tyr Arg Asp 
    130                 135                 140                 


Ser Tyr Ile Arg Phe Ser Thr Gln Pro Phe Ser Leu Lys Asn Leu Asp 
145                 150                 155                 160 


Asn Ser Val His Leu Cys Asn Asn Ser Ile Gln Lys His Leu Glu Asn 
                165                 170                 175     


Ser Cys His Arg His Pro Leu Leu Pro Pro Asp Asn Met Trp Ser Ser 
            180                 185                 190         


Gln Arg Phe Gln Ala His Leu Gln Glu Met Gly Ala Pro Asn Ala Trp 
        195                 200                 205             


Ser Thr Ile Ile Val Pro Gly Met Lys Asp Ala Val Ile His Ala Leu 
    210                 215                 220                 


Gln Thr Ser Gln Asp Thr Val Gln Cys Arg Lys Ala Ser Phe Glu Leu 
225                 230                 235                 240 


Tyr Gly Ala Asp Phe Val Phe Gly Glu Asp Phe Gln Pro Trp Leu Ile 
                245                 250                 255     


Glu Ile Asn Ala Ser Pro Thr Met Ala Pro Ser Thr Ala Val Thr Ala 
            260                 265                 270         


Arg Leu Cys Ala Gly Val Gln Ala Asp Thr Leu Arg Val Val Ile Asp 
        275                 280                 285             


Arg Met Leu Asp Arg Asn Cys Asp Thr Gly Ala Phe Glu Leu Ile Tyr 
    290                 295                 300                 


Lys Gln Pro Val Thr Thr Ser Pro Ala Ser Thr Pro Arg Pro Ser Cys 
305                 310                 315                 320 


Leu Leu Pro Met Tyr Ser Asp Thr Arg Ala Arg Ser Ser Asp Asp Ser 
                325                 330                 335     


Thr Ala Ser Trp Trp Ala Leu Arg Pro Cys Arg Pro Gln Ala Arg Pro 
            340                 345                 350         


<210> 6982
<211> 168
<212> PRT
<213> Homo sapiens

<400> 6982
Met Thr Ala Thr Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Thr Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu Leu Leu Leu 
        35                  40                  45              


Gln Pro Val Thr Ile Ser Arg Asn Glu Lys Glu Lys Val Leu Ile Glu 
    50                  55                  60                  


Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys Gln Ala Asp 
65                  70                  75                  80  


Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe Met Met Met 
                85                  90                  95      


Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val Glu Gly Tyr 
            100                 105                 110         


Asp Ile Ser Phe Leu Ile Thr Asn Phe His Thr Glu Gln Met Tyr Lys 
        115                 120                 125             


His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu Ile Asp Lys 
    130                 135                 140                 


Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala Arg Ile Val 
145                 150                 155                 160 


Ala Glu Glu Phe Leu Lys Asn Phe 
                165             


<210> 6983
<211> 330
<212> PRT
<213> Homo sapiens

<400> 6983
Met Glu Arg Phe Met Glu Gln Val Val Phe Lys Tyr Leu Arg Ala Glu 
1               5                   10                  15      


Pro Glu Asp His Tyr Phe Leu Met Thr Glu Pro Pro Leu Asn Thr Pro 
            20                  25                  30          


Glu Asn Arg Glu Tyr Leu Ala Glu Ile Met Phe Glu Ser Phe Asn Val 
        35                  40                  45              


Pro Gly Leu Tyr Ile Ala Val Gln Ala Val Leu Ala Leu Ala Ala Ser 
    50                  55                  60                  


Trp Thr Ser Arg Gln Val Gly Glu Arg Thr Leu Thr Gly Ile Val Ile 
65                  70                  75                  80  


Asp Ser Gly Asp Gly Val Thr His Val Ile Pro Val Ala Glu Gly Tyr 
                85                  90                  95      


Val Ile Gly Ser Cys Ile Lys His Ile Pro Ile Ala Gly Arg Asp Ile 
            100                 105                 110         


Thr Tyr Phe Ile Gln Gln Leu Leu Arg Glu Arg Glu Val Gly Ile Pro 
        115                 120                 125             


Pro Glu Gln Ser Leu Glu Thr Ala Lys Ala Ile Lys Glu Lys Tyr Cys 
    130                 135                 140                 


Tyr Ile Cys Pro Asp Ile Val Lys Glu Phe Ala Lys Tyr Asp Val Asp 
145                 150                 155                 160 


Pro Arg Lys Trp Ile Lys Gln Tyr Thr Gly Ile Asn Ala Ile Asn Gln 
                165                 170                 175     


Lys Lys Phe Val Ile Asp Val Gly Tyr Glu Arg Phe Leu Gly Pro Glu 
            180                 185                 190         


Ile Phe Phe His Pro Glu Phe Ala Asn Pro Asp Phe Met Glu Ser Ile 
        195                 200                 205             


Ser Asp Val Val Asp Glu Val Ile Gln Asn Cys Pro Ile Asp Val Arg 
    210                 215                 220                 


Arg Pro Leu Tyr Lys Asn Val Val Leu Ser Gly Gly Ser Thr Met Phe 
225                 230                 235                 240 


Arg Asp Phe Gly Arg Arg Leu Gln Arg Asp Leu Lys Arg Val Val Asp 
                245                 250                 255     


Ala Arg Leu Arg Leu Ser Glu Glu Leu Ser Gly Gly Arg Ile Lys Pro 
            260                 265                 270         


Lys Pro Val Glu Val Gln Val Val Thr His His Met Gln Arg Tyr Ala 
        275                 280                 285             


Val Trp Phe Gly Gly Ser Met Leu Ala Ser Thr Pro Glu Phe Phe Gln 
    290                 295                 300                 


Val Cys His Thr Lys Lys Asp Tyr Glu Glu Tyr Gly Pro Ser Ile Cys 
305                 310                 315                 320 


Arg His Asn Pro Val Phe Gly Val Met Ser 
                325                 330 


<210> 6984
<211> 297
<212> PRT
<213> Homo sapiens

<400> 6984
Met Lys Thr Leu Ser Pro Asp Arg Ile Gln Pro His Ile Met Thr Asp 
1               5                   10                  15      


Val Pro Ala Thr Phe Thr Gln Ala Glu Cys Asn Gly Asp Lys Pro Pro 
            20                  25                  30          


Glu Asn Gly Gln Gln Thr Ile Thr Lys Ile Ser Glu Glu Leu Thr Asp 
        35                  40                  45              


Val Asp Ser Pro Leu Pro His Tyr Arg Val Glu Pro Ser Leu Glu Gly 
    50                  55                  60                  


Ala Leu Thr Lys Gly Ser Gln Glu Glu Arg Arg Lys Leu Gln Gly Asn 
65                  70                  75                  80  


Met Leu Leu Asn Ser Ser Met Glu Asp Lys Met Leu Lys Glu Asn Pro 
                85                  90                  95      


Glu Glu Lys Leu Phe Ile Val His Lys Ala Ile Thr Asp Leu Ser Leu 
            100                 105                 110         


Gln Glu Thr Ser Ala Asp Glu Met Thr Phe Arg Glu Gly His Gln Trp 
        115                 120                 125             


Glu Lys Ile Pro Leu Ser Gly Ser Asn Gln Glu Ile Arg Arg Gln Lys 
    130                 135                 140                 


Glu Arg Ile Thr Glu Gln Pro Leu Lys Glu Glu Glu Asp Glu Asp Arg 
145                 150                 155                 160 


Lys Asn Lys Gly His Gln Ala Ala Glu Ile Glu Trp Leu Gly Phe Arg 
                165                 170                 175     


Lys Pro Ser Gln Ala Asp Met Leu His Ser Lys His Asp Glu Glu Gln 
            180                 185                 190         


Lys Val Trp Asp Glu Glu Ile Asp Asp Asp Asp Asp Asp Asn Cys Asn 
        195                 200                 205             


Asn Asp Glu Asp Glu Val Arg Val Ile Glu Phe Lys Lys Lys His Glu 
    210                 215                 220                 


Glu Val Ser Gln Phe Lys Glu Glu Gly Asp Ala Ser Glu Asp Ser Pro 
225                 230                 235                 240 


Leu Ser Ser Ala Ser Ser Gln Ala Val Thr Pro Asp Glu Gln Pro Thr 
                245                 250                 255     


Leu Gly Lys Lys Ser Asp Ile Ser Arg Asn Ala Tyr Ser Arg Tyr Asn 
            260                 265                 270         


Thr Ile Ser Tyr Arg Lys Ile Arg Lys Gly Asn Thr Lys Gln Arg Ile 
        275                 280                 285             


Asp Glu Phe Glu Ser Met Met His Leu 
    290                 295         


<210> 6985
<211> 357
<212> PRT
<213> Homo sapiens

<400> 6985
Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro Pro Pro Gln Asn 
1               5                   10                  15      


Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln Asp Tyr Ala Gly 
            20                  25                  30          


Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser Thr Gln Ala His 
        35                  40                  45              


Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn Gly Ser Leu Thr 
    50                  55                  60                  


Gln Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser Gln Thr Gln 
65                  70                  75                  80  


Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg Leu His Val 
                85                  90                  95      


Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe 
            100                 105                 110         


Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg 
        115                 120                 125             


Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala 
    130                 135                 140                 


Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys 
145                 150                 155                 160 


Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Met 
                165                 170                 175     


Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro Val Val Gly Ala 
            180                 185                 190         


Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe Gln Ala Asp Val 
        195                 200                 205             


Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly Arg Gly Gly Ile 
    210                 215                 220                 


Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro Tyr Pro Thr Ala 
225                 230                 235                 240 


Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu Arg Gly Arg Gly 
                245                 250                 255     


Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro Thr Ala Ile Pro 
            260                 265                 270         


Ala Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr Gly Ala Asp Leu 
        275                 280                 285             


Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln Pro Ala Thr Ala Thr 
    290                 295                 300                 


Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Tyr Ser Asp Gly Tyr 
305                 310                 315                 320 


Gly Arg Val Tyr Thr Ala Asp Pro Tyr His Ala Leu Ala Pro Ala Ala 
                325                 330                 335     


Ser Tyr Gly Val Gly Ala Val Ala Ser Leu Tyr Arg Gly Gly Tyr Ser 
            340                 345                 350         


Arg Phe Ala Pro Tyr 
        355         


<210> 6986
<211> 128
<212> PRT
<213> Homo sapiens

<400> 6986
Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro Pro Pro Gln Asn 
1               5                   10                  15      


Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln Asp Tyr Ala Gly 
            20                  25                  30          


Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser Thr Gln Ala His 
        35                  40                  45              


Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn Gly Ser Leu Thr 
    50                  55                  60                  


Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser Gln Thr Gln Ser 
65                  70                  75                  80  


Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg Leu His Val Ser 
                85                  90                  95      


Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly 
            100                 105                 110         


Phe Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser 
        115                 120                 125             


<210> 6987
<211> 356
<212> PRT
<213> Homo sapiens

<400> 6987
Met Gln Gly Ile Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro 
1               5                   10                  15      


Tyr Ile Gln Ile Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly 
            20                  25                  30          


Tyr Trp Gly Asn Lys Gly Gly Val Asn Ile Cys Leu Lys Leu Tyr Gly 
        35                  40                  45              


Tyr Tyr Val Ser Ile Ile Asn Cys His Leu Pro Pro His Ile Ser Asn 
    50                  55                  60                  


Asn Tyr Gln Arg Leu Glu His Phe Asp Arg Ile Leu Glu Met Gln Asn 
65                  70                  75                  80  


Cys Glu Gly Arg Asp Ile Pro Asn Ile Leu Asp His Asp Leu Ile Ile 
                85                  90                  95      


Trp Phe Gly Asp Met Asn Phe Arg Ile Glu Asp Phe Gly Leu His Phe 
            100                 105                 110         


Val Arg Glu Ser Ile Lys Asn Arg Cys Tyr Gly Gly Leu Trp Glu Lys 
        115                 120                 125             


Asp Gln Leu Ser Ile Ala Lys Lys His Asp Pro Leu Leu Arg Glu Phe 
    130                 135                 140                 


Gln Glu Gly Arg Leu Leu Phe Pro Pro Thr Tyr Lys Phe Asp Arg Asn 
145                 150                 155                 160 


Ser Asn Asp Tyr Asp Thr Ser Glu Lys Lys Arg Lys Pro Ala Trp Thr 
                165                 170                 175     


Asp Arg Ile Leu Trp Arg Leu Lys Arg Gln Pro Cys Ala Gly Pro Asp 
            180                 185                 190         


Thr Pro Ile Pro Pro Ala Ser His Phe Ser Leu Ser Leu Arg Gly Tyr 
        195                 200                 205             


Ser Ser His Met Thr Tyr Gly Ile Ser Asp His Lys Pro Val Ser Gly 
    210                 215                 220                 


Thr Phe Asp Leu Glu Leu Lys Pro Leu Val Ser Ala Pro Leu Ile Val 
225                 230                 235                 240 


Leu Met Pro Glu Asp Leu Trp Thr Val Glu Asn Asp Met Met Val Ser 
                245                 250                 255     


Tyr Ser Ser Thr Ser Asp Phe Pro Ser Ser Pro Trp Asp Trp Ile Gly 
            260                 265                 270         


Leu Tyr Lys Val Gly Leu Arg Asp Val Asn Asp Tyr Val Ser Tyr Ala 
        275                 280                 285             


Trp Val Gly Asp Ser Lys Val Ser Cys Ser Asp Asn Leu Asn Gln Val 
    290                 295                 300                 


Tyr Ile Asp Ile Ser Asn Ile Pro Thr Thr Glu Asp Glu Phe Leu Leu 
305                 310                 315                 320 


Cys Tyr Tyr Ser Asn Ser Leu Arg Ser Val Val Gly Ile Ser Arg Pro 
                325                 330                 335     


Phe Gln Ile Pro Pro Gly Ser Leu Arg Glu Asp Pro Leu Gly Glu Ala 
            340                 345                 350         


Gln Pro Gln Ile 
        355     


<210> 6988
<211> 583
<212> PRT
<213> Homo sapiens

<400> 6988
Met Leu Ser Glu Ser Lys Glu Gly Glu Glu Lys Glu Glu Val Thr Met 
1               5                   10                  15      


Asp Thr Ser Glu Asn Arg Pro Glu Asn Asp Val Pro Glu Pro Pro Met 
            20                  25                  30          


Pro Ile Ala Asp Gln Val Ser Asn Asp Asp Arg Pro Glu Gly Ser Val 
        35                  40                  45              


Glu Asp Glu Glu Lys Lys Glu Ser Ser Leu Pro Lys Ser Phe Lys Arg 
    50                  55                  60                  


Lys Ile Ser Val Val Ser Ala Thr Lys Gly Val Pro Ala Gly Asn Ser 
65                  70                  75                  80  


Asp Thr Glu Gly Gly Gln Pro Gly Arg Lys Arg Arg Trp Gly Ala Ser 
                85                  90                  95      


Thr Ala Thr Thr Gln Lys Lys Pro Ser Ile Ser Ile Thr Thr Glu Ser 
            100                 105                 110         


Leu Lys Ser Leu Ile Pro Asp Ile Lys Pro Leu Ala Gly Gln Glu Ala 
        115                 120                 125             


Val Val Asp Leu His Ala Asp Asp Ser Arg Ile Ser Glu Asp Glu Thr 
    130                 135                 140                 


Glu Arg Asn Gly Asp Asp Gly Thr His Asp Lys Gly Leu Lys Ile Cys 
145                 150                 155                 160 


Arg Thr Val Thr Gln Val Val Pro Ala Glu Gly Gln Glu Asn Gly Gln 
                165                 170                 175     


Arg Glu Glu Glu Glu Glu Glu Lys Glu Pro Glu Ala Glu Pro Pro Val 
            180                 185                 190         


Pro Pro Gln Val Ser Val Glu Val Ala Leu Pro Pro Pro Ala Glu His 
        195                 200                 205             


Glu Val Lys Lys Val Thr Leu Gly Asp Thr Leu Thr Arg Arg Ser Ile 
    210                 215                 220                 


Ser Gln Gln Lys Ser Gly Val Ser Ile Thr Ile Asp Asp Pro Val Arg 
225                 230                 235                 240 


Thr Ala Gln Val Pro Ser Pro Pro Arg Gly Lys Ile Ser Asn Ile Val 
                245                 250                 255     


His Ile Ser Asn Leu Val Arg Pro Phe Thr Leu Gly Gln Leu Lys Glu 
            260                 265                 270         


Leu Leu Gly Arg Thr Gly Thr Leu Val Glu Glu Ala Phe Trp Ile Asp 
        275                 280                 285             


Lys Ile Lys Ser His Cys Phe Val Thr Tyr Ser Thr Val Glu Glu Ala 
    290                 295                 300                 


Val Ala Thr Arg Thr Ala Leu His Gly Val Lys Trp Pro Gln Ser Asn 
305                 310                 315                 320 


Pro Lys Phe Leu Cys Ala Asp Tyr Ala Glu Gln Asp Glu Leu Asp Tyr 
                325                 330                 335     


His Arg Gly Leu Leu Val Asp Arg Pro Ser Glu Thr Lys Thr Glu Glu 
            340                 345                 350         


Gln Gly Ile Pro Arg Pro Leu His Pro Pro Pro Pro Pro Pro Val Gln 
        355                 360                 365             


Pro Pro Gln His Pro Arg Ala Glu Gln Arg Glu Gln Glu Arg Ala Val 
    370                 375                 380                 


Arg Glu Gln Trp Ala Glu Arg Glu Arg Glu Met Glu Arg Arg Glu Arg 
385                 390                 395                 400 


Thr Arg Ser Glu Arg Glu Trp Asp Arg Asp Lys Val Arg Glu Gly Pro 
                405                 410                 415     


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Arg Lys Glu Arg Ala Lys 
            420                 425                 430         


Ser Lys Glu Lys Lys Ser Glu Lys Lys Glu Lys Ala Gln Glu Glu Pro 
        435                 440                 445             


Pro Ala Lys Leu Leu Asp Asp Leu Phe Arg Lys Thr Lys Ala Ala Pro 
    450                 455                 460                 


Cys Ile Tyr Trp Leu Pro Leu Thr Asp Ser Gln Ile Val Gln Lys Glu 
465                 470                 475                 480 


Ala Glu Arg Ala Glu Arg Ala Lys Glu Arg Glu Lys Arg Arg Lys Glu 
                485                 490                 495     


Gln Glu Glu Glu Glu Gln Lys Glu Arg Glu Lys Glu Ala Glu Arg Glu 
            500                 505                 510         


Arg Asn Arg Gln Leu Glu Arg Glu Lys Arg Arg Glu His Ser Arg Glu 
        515                 520                 525             


Arg Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg Gly Asp Arg 
    530                 535                 540                 


Asp Arg Asp Arg Glu Arg Asp Arg Glu Arg Gly Arg Glu Arg Asp Arg 
545                 550                 555                 560 


Arg Asp Thr Lys Arg His Ser Arg Ser Arg Ser Arg Ser Thr Pro Val 
                565                 570                 575     


Arg Asp Arg Gly Gly Arg Arg 
            580             


<210> 6989
<211> 442
<212> PRT
<213> Homo sapiens

<400> 6989
Met Ala Asn Ser Phe Ala Ala Arg Ile Phe Thr Thr Leu Ser Asp Leu 
1               5                   10                  15      


Gln Thr Asn Met Ala Asn Leu Lys Val Ile Gly Ile Val Ile Gly Lys 
            20                  25                  30          


Thr Asp Val Lys Gly Phe Pro Asp Arg Lys Asn Ile Gly Ser Glu Arg 
        35                  40                  45              


Tyr Thr Phe Ser Phe Thr Ile Arg Asp Ser Pro Ala His Phe Val Asn 
    50                  55                  60                  


Ala Ala Ser Trp Gly Asn Glu Asp Tyr Ile Lys Ser Leu Ser Asp Ser 
65                  70                  75                  80  


Phe Arg Val Gly Asp Cys Val Ile Ile Glu Asn Pro Leu Ile Gln Arg 
                85                  90                  95      


Lys Glu Ile Glu Arg Glu Glu Lys Phe Ser Pro Ala Thr Pro Ser Asn 
            100                 105                 110         


Cys Lys Leu Leu Leu Ser Glu Asn His Ser Thr Val Lys Val Cys Ser 
        115                 120                 125             


Ser Tyr Glu Val Asp Thr Lys Leu Leu Ser Leu Ile His Leu Pro Val 
    130                 135                 140                 


Lys Glu Ser His Asp Tyr Tyr Ser Leu Gly Asp Ile Val Ala Asn Gly 
145                 150                 155                 160 


His Ser Leu Asn Gly Arg Ile Ile Asn Val Leu Ala Ala Val Lys Ser 
                165                 170                 175     


Val Gly Glu Pro Lys Tyr Phe Thr Thr Ser Asp Arg Arg Lys Gly Gln 
            180                 185                 190         


Arg Cys Glu Val Arg Leu Tyr Asp Glu Thr Glu Ser Ser Phe Ala Met 
        195                 200                 205             


Thr Cys Trp Asp Asn Glu Ser Ile Leu Leu Ala Gln Ser Trp Met Pro 
    210                 215                 220                 


Arg Glu Thr Val Ile Phe Ala Ser Asp Val Arg Ile Asn Phe Asp Lys 
225                 230                 235                 240 


Phe Arg Asn Cys Met Thr Ala Thr Val Ile Ser Lys Thr Ile Ile Thr 
                245                 250                 255     


Thr Asn Pro Asp Ile Pro Glu Ala Asn Ile Leu Leu Asn Phe Ile Arg 
            260                 265                 270         


Glu Asn Lys Glu Thr Asn Val Leu Asp Asp Glu Ile Asp Ser Tyr Phe 
        275                 280                 285             


Lys Glu Ser Ile Asn Leu Ser Thr Ile Val Asp Val Tyr Thr Val Glu 
    290                 295                 300                 


Gln Leu Lys Gly Lys Ala Leu Lys Asn Glu Gly Lys Ala Asp Pro Ser 
305                 310                 315                 320 


Tyr Gly Ile Leu Tyr Ala Tyr Ile Ser Thr Leu Asn Ile Asp Asp Glu 
                325                 330                 335     


Thr Thr Lys Val Val Arg Asn Arg Cys Ser Ser Cys Gly Tyr Ile Val 
            340                 345                 350         


Asn Glu Ala Ser Asn Met Cys Thr Thr Cys Asn Lys Asn Ser Leu Asp 
        355                 360                 365             


Phe Lys Ser Val Phe Leu Ser Phe His Val Leu Ile Asp Leu Thr Asp 
    370                 375                 380                 


His Thr Gly Thr Leu His Ser Cys Ser Leu Thr Gly Ser Val Ala Glu 
385                 390                 395                 400 


Glu Thr Leu Gly Cys Thr Phe Val Leu Ser His Arg Ala Arg Ser Gly 
                405                 410                 415     


Leu Lys Ile Ser Val Leu Ser Cys Lys Leu Ala Asp Pro Thr Glu Ala 
            420                 425                 430         


Ser Arg Asn Leu Ser Gly Gln Lys His Val 
        435                 440         


<210> 6990
<211> 208
<212> PRT
<213> Homo sapiens

<400> 6990
Met Ala Gly Thr Ala Arg His Asp Arg Glu Met Ala Ile Gln Ala Lys 
1               5                   10                  15      


Lys Lys Leu Thr Thr Ala Thr Asp Pro Ile Glu Arg Leu Arg Leu Gln 
            20                  25                  30          


Cys Leu Ala Arg Gly Ser Ala Gly Ile Lys Gly Leu Gly Arg Val Phe 
        35                  40                  45              


Arg Ile Met Asp Asp Asp Asn Asn Arg Thr Leu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Met Lys Gly Leu Asn Asp Tyr Ala Val Val Met Glu Lys Glu Glu Val 
65                  70                  75                  80  


Glu Glu Leu Phe Arg Arg Phe Asp Lys Asp Gly Asn Gly Thr Ile Asp 
                85                  90                  95      


Phe Asn Glu Phe Leu Leu Thr Leu Arg Pro Pro Met Ser Arg Ala Arg 
            100                 105                 110         


Lys Glu Val Ile Met Gln Ala Phe Arg Lys Leu Asp Lys Thr Gly Asp 
        115                 120                 125             


Gly Val Ile Thr Ile Glu Asp Leu Arg Glu Val Tyr Asn Ala Lys His 
    130                 135                 140                 


His Pro Lys Tyr Gln Asn Gly Glu Trp Ser Glu Glu Gln Val Phe Arg 
145                 150                 155                 160 


Lys Phe Leu Asp Asn Phe Asp Ser Pro Tyr Asp Lys Asp Gly Leu Val 
                165                 170                 175     


Thr Pro Glu Glu Phe Met Asn Tyr Tyr Ala Gly Val Ser Ala Ser Ile 
            180                 185                 190         


Asp Thr Asp Val Tyr Phe Ile Ile Met Met Arg Thr Ala Trp Lys Leu 
        195                 200                 205             


<210> 6991
<211> 208
<212> PRT
<213> Homo sapiens

<400> 6991
Met Ala Gly Thr Ala Arg His Asp Arg Glu Met Ala Ile Gln Ala Lys 
1               5                   10                  15      


Lys Lys Leu Thr Thr Ala Thr Asp Pro Ile Glu Arg Leu Arg Leu Gln 
            20                  25                  30          


Cys Leu Ala Arg Gly Ser Ala Gly Ile Lys Gly Leu Gly Arg Val Phe 
        35                  40                  45              


Arg Ile Met Asp Asp Asp Asn Asn Arg Thr Leu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Met Lys Gly Leu Asn Asp Tyr Ala Val Val Met Glu Lys Glu Glu Val 
65                  70                  75                  80  


Glu Glu Leu Phe Arg Arg Phe Asp Lys Asp Gly Asn Gly Thr Ile Asp 
                85                  90                  95      


Phe Asn Glu Phe Leu Leu Thr Leu Arg Pro Pro Met Ser Arg Ala Arg 
            100                 105                 110         


Lys Glu Val Ile Met Gln Ala Phe Arg Lys Leu Asp Lys Thr Gly Asp 
        115                 120                 125             


Gly Val Ile Thr Ile Glu Asp Leu Arg Glu Val Tyr Asn Ala Lys His 
    130                 135                 140                 


His Pro Lys Tyr Gln Asn Gly Glu Trp Ser Glu Glu Gln Val Phe Arg 
145                 150                 155                 160 


Lys Phe Leu Asp Asn Phe Asp Ser Pro Tyr Asp Lys Asp Gly Leu Val 
                165                 170                 175     


Thr Pro Glu Glu Phe Met Asn Tyr Tyr Ala Gly Val Ser Ala Ser Ile 
            180                 185                 190         


Asp Thr Asp Val Tyr Phe Ile Ile Met Met Arg Thr Ala Trp Lys Leu 
        195                 200                 205             


<210> 6992
<211> 262
<212> PRT
<213> Homo sapiens

<400> 6992
His Ser Tyr Ser Glu Gly Leu Gly His Pro Arg Val Ser Gln Ala Leu 
1               5                   10                  15      


Val Thr Phe His Gln Gln Lys Pro Ile Glu Pro Arg Arg Glu Leu Leu 
            20                  25                  30          


Thr Gln Pro Cys Arg Gln Lys Asp Pro Ala Asn Val Asp Tyr Glu Asp 
        35                  40                  45              


Leu Phe Leu Tyr Ser Asn Ala Val Ala Glu Glu Ala Ala Cys Pro Val 
    50                  55                  60                  


Ser Ala Pro Glu Glu Ala Ser Pro Lys Pro Val Leu Cys His Gln Ser 
65                  70                  75                  80  


Lys Glu Arg Lys Pro Ser Ala Glu Met Asn Arg Ile Thr Thr Lys Glu 
                85                  90                  95      


Ala Thr Ser Ser Cys Pro Pro Lys Ser Pro Leu Gly Glu Thr Arg Gln 
            100                 105                 110         


Lys Leu Trp Arg Ser Leu Lys Met Leu Pro Glu Arg Gly Gln Arg Val 
        115                 120                 125             


Arg Gln Gln Lys Ser His Leu Ala Thr Val Asn Leu Ser Ser Leu Leu 
    130                 135                 140                 


Asp Val Arg Arg Ser Thr Val Ile Ser Gly Pro Gly Thr Gly Lys Gly 
145                 150                 155                 160 


Ser Gln Asp His Ser Gly Asp Pro Thr Ser Gly Asp Arg Gly Tyr Thr 
                165                 170                 175     


Asp Pro Cys Val Ala Thr Ser Leu Lys Ser Pro Ser Gln Pro Gln Ala 
            180                 185                 190         


Pro Lys Asp Arg Lys Val Pro Thr Arg Lys Ala Glu Arg Ser Val Ser 
        195                 200                 205             


Cys Ile Glu Val Thr Pro Gly Asp Arg Ser Trp His Gln Met Val Val 
    210                 215                 220                 


Arg Ala Leu Ser Ser Gln Glu Ser Lys Pro Glu His Gln Gly Leu Ala 
225                 230                 235                 240 


Glu Pro Glu Asn Asp Gln Leu Pro Glu Glu Tyr Gln Gln Pro Pro Pro 
                245                 250                 255     


Phe Ala Pro Gly Tyr Cys 
            260         


<210> 6993
<211> 646
<212> PRT
<213> Homo sapiens

<400> 6993
Met Ser Tyr Thr Gly Phe Val Gln Gly Ser Glu Thr Thr Leu Gln Ser 
1               5                   10                  15      


Thr Tyr Ser Asp Thr Ser Ala Gln Pro Thr Cys Asp Tyr Gly Tyr Gly 
            20                  25                  30          


Thr Trp Asn Ser Gly Thr Asn Arg Gly Tyr Glu Gly Tyr Gly Tyr Gly 
        35                  40                  45              


Tyr Gly Tyr Gly Gln Asp Asn Thr Thr Asn Tyr Gly Tyr Gly Met Ala 
    50                  55                  60                  


Thr Ser His Ser Trp Glu Met Pro Ser Ser Asp Thr Asn Ala Asn Thr 
65                  70                  75                  80  


Ser Ala Ser Gly Ser Ala Ser Ala Asp Ser Val Leu Ser Arg Ile Asn 
                85                  90                  95      


Gln Arg Leu Asp Met Val Pro His Leu Glu Thr Asp Met Met Gln Gly 
            100                 105                 110         


Gly Val Tyr Gly Ser Gly Gly Glu Arg Tyr Asp Ser Tyr Glu Ser Cys 
        115                 120                 125             


Asp Ser Arg Ala Val Leu Ser Glu Arg Asp Leu Tyr Arg Ser Gly Tyr 
    130                 135                 140                 


Asp Tyr Ser Glu Leu Asp Pro Glu Met Glu Met Ala Tyr Glu Gly Gln 
145                 150                 155                 160 


Tyr Asp Ala Tyr Arg Asp Gln Phe Arg Met Arg Gly Asn Asp Thr Phe 
                165                 170                 175     


Gly Pro Arg Ala Gln Gly Trp Ala Arg Asp Ala Arg Ser Gly Arg Pro 
            180                 185                 190         


Met Ala Ser Gly Tyr Gly Arg Met Trp Glu Asp Pro Met Gly Ala Arg 
        195                 200                 205             


Gly Gln Cys Met Ser Gly Ala Ser Arg Leu Pro Ser Leu Phe Ser Gln 
    210                 215                 220                 


Asn Ile Ile Pro Glu Tyr Gly Met Phe Gln Gly Met Arg Gly Gly Gly 
225                 230                 235                 240 


Ala Phe Pro Gly Gly Ser Arg Phe Gly Phe Gly Phe Gly Asn Gly Met 
                245                 250                 255     


Lys Gln Met Arg Arg Thr Trp Lys Thr Trp Thr Thr Ala Asp Phe Arg 
            260                 265                 270         


Thr Lys Lys Lys Lys Arg Lys Gln Gly Gly Ser Pro Asp Glu Pro Asp 
        275                 280                 285             


Ser Lys Ala Thr Arg Thr Asp Cys Ser Asp Asn Ser Asp Ser Asp Asn 
    290                 295                 300                 


Asp Glu Gly Thr Glu Gly Glu Ala Thr Glu Gly Leu Glu Gly Thr Glu 
305                 310                 315                 320 


Ala Val Glu Lys Gly Ser Arg Val Asp Gly Glu Asp Glu Glu Gly Lys 
                325                 330                 335     


Glu Asp Gly Arg Glu Glu Gly Lys Glu Asp Pro Glu Lys Gly Ala Leu 
            340                 345                 350         


Thr Thr Gln Asp Glu Asn Gly Gln Thr Lys Arg Lys Leu Gln Ala Gly 
        355                 360                 365             


Lys Lys Ser Gln Asp Lys Gln Lys Lys Arg Gln Arg Asp Arg Met Val 
    370                 375                 380                 


Glu Arg Ile Gln Phe Val Cys Ser Leu Cys Lys Tyr Arg Thr Phe Tyr 
385                 390                 395                 400 


Glu Asp Glu Met Ala Ser His Leu Asp Ser Lys Phe His Lys Glu His 
                405                 410                 415     


Phe Lys Tyr Val Gly Thr Lys Leu Pro Lys Gln Thr Ala Asp Phe Leu 
            420                 425                 430         


Gln Glu Tyr Val Thr Asn Lys Thr Lys Lys Thr Glu Glu Leu Arg Lys 
        435                 440                 445             


Thr Val Glu Asp Leu Asp Gly Leu Ile His Gln Ile Tyr Arg Asp Gln 
    450                 455                 460                 


Asp Leu Thr Gln Glu Ile Ala Met Glu His Phe Val Lys Lys Val Glu 
465                 470                 475                 480 


Ala Ala His Cys Ala Ala Cys Asp Leu Phe Ile Pro Met Gln Phe Gly 
                485                 490                 495     


Ile Ile Gln Lys His Leu Lys Thr Met Asp His Asn Arg Asn Arg Arg 
            500                 505                 510         


Leu Met Met Glu Gln Ser Lys Lys Ser Ser Leu Met Val Ala Arg Ser 
        515                 520                 525             


Ile Leu Asn Asn Lys Leu Ile Ser Lys Lys Leu Glu Arg Tyr Leu Lys 
    530                 535                 540                 


Gly Glu Asn Pro Phe Thr Asp Ser Pro Glu Glu Glu Lys Glu Gln Glu 
545                 550                 555                 560 


Glu Ala Glu Gly Gly Ala Leu Asp Glu Gly Ala Gln Gly Glu Ala Ala 
                565                 570                 575     


Gly Ile Ser Glu Gly Ala Glu Gly Val Pro Ala Gln Pro Pro Val Pro 
            580                 585                 590         


Pro Glu Pro Ala Pro Gly Ala Val Ser Pro Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Glu Glu Glu Glu Glu Gly Ala Val Pro Leu Leu Gly Gly Ala Leu Gln 
    610                 615                 620                 


Arg Gln Ile Arg Gly Ile Pro Gly Leu Asp Val Glu Asp Asp Glu Glu 
625                 630                 635                 640 


Gly Gly Gly Gly Ala Pro 
                645     


<210> 6994
<211> 466
<212> PRT
<213> Homo sapiens

<400> 6994
Met Arg Gly Pro Asn Ser Gly Thr Glu Lys Gly Arg Leu Val Ile Pro 
1               5                   10                  15      


Glu Lys Gln Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro Arg 
            20                  25                  30          


Phe Lys Arg Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly Pro 
        35                  40                  45              


Gln Thr Arg Ser Asp Leu Leu Leu Ser Gly Arg Asp Trp Asn Thr Leu 
    50                  55                  60                  


Ile Val Gly Lys Leu Ser Pro Trp Ile Arg Pro Asp Ser Lys Val Glu 
65                  70                  75                  80  


Lys Ile Arg Arg Asn Ser Glu Ala Leu Glu Val Gln Phe Ile Ile Thr 
                85                  90                  95      


Gly Thr Asn His His Ser Glu Lys Glu Phe Cys Ser Tyr Leu Gln Tyr 
            100                 105                 110         


Leu Glu Tyr Leu Ser Gln Asn Arg Pro Pro Pro Asn Ala Tyr Glu Leu 
        115                 120                 125             


Phe Ala Lys Gly Tyr Glu Asp Tyr Leu Gln Ser Pro Leu Gln Pro Leu 
    130                 135                 140                 


Met Asp Asn Leu Glu Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro 
145                 150                 155                 160 


Ile Lys Tyr Ser Gln Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp 
                165                 170                 175     


Arg Val Pro Glu Glu Glu Lys Asp Thr Asn Val Gln Val Leu Met Val 
            180                 185                 190         


Leu Gly Ala Gly Arg Gly Pro Leu Val Asn Ala Ser Leu Arg Ala Ala 
        195                 200                 205             


Lys Gln Ala Asp Arg Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro 
    210                 215                 220                 


Asn Ala Val Val Thr Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser 
225                 230                 235                 240 


Gln Val Thr Val Val Ser Ser Asp Met Arg Glu Trp Val Ala Pro Glu 
                245                 250                 255     


Lys Ala Asp Ile Ile Val Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn 
            260                 265                 270         


Glu Leu Ser Pro Glu Cys Leu Asp Gly Ala Gln His Phe Leu Lys Asp 
        275                 280                 285             


Asp Gly Val Ser Ile Pro Gly Glu Tyr Thr Ser Phe Leu Ala Pro Ile 
    290                 295                 300                 


Ser Ser Ser Lys Leu Tyr Asn Glu Val Arg Ala Cys Arg Glu Lys Asp 
305                 310                 315                 320 


Arg Asp Pro Glu Ala Gln Phe Glu Met Pro Tyr Val Val Arg Leu His 
                325                 330                 335     


Asn Phe His Gln Leu Ser Ala Pro Gln Pro Cys Phe Thr Phe Ser His 
            340                 345                 350         


Pro Asn Arg Asp Pro Met Ile Asp Asn Asn Arg Tyr Cys Thr Leu Glu 
        355                 360                 365             


Phe Pro Val Glu Val Asn Thr Val Leu His Gly Phe Ala Gly Tyr Phe 
    370                 375                 380                 


Glu Thr Val Leu Tyr Gln Asp Ile Thr Leu Ser Ile Arg Pro Glu Thr 
385                 390                 395                 400 


His Ser Pro Gly Met Phe Ser Trp Phe Pro Ile Leu Phe Pro Ile Lys 
                405                 410                 415     


Gln Pro Ile Thr Val Arg Glu Gly Gln Thr Ile Cys Val Arg Phe Trp 
            420                 425                 430         


Arg Cys Ser Asn Ser Lys Lys Val Trp Tyr Glu Trp Ala Val Thr Ala 
        435                 440                 445             


Pro Val Cys Ser Ala Ile His Asn Pro Thr Gly Arg Ser Tyr Thr Ile 
    450                 455                 460                 


Gly Leu 
465     


<210> 6995
<211> 620
<212> PRT
<213> Homo sapiens

<400> 6995
Met Arg Gly Pro Asn Ser Gly Thr Glu Lys Gly Arg Leu Val Ile Pro 
1               5                   10                  15      


Glu Lys Gln Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro Arg 
            20                  25                  30          


Phe Lys Arg Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly Pro 
        35                  40                  45              


Gln Thr Arg Ser Asp Leu Leu Leu Ser Gly Arg Asp Trp Asn Thr Leu 
    50                  55                  60                  


Ile Val Gly Lys Leu Ser Pro Trp Ile Arg Pro Asp Ser Lys Val Glu 
65                  70                  75                  80  


Lys Ile Arg Arg Asn Ser Glu Ala Ala Met Leu Gln Glu Leu Asn Phe 
                85                  90                  95      


Gly Ala Tyr Leu Gly Leu Pro Ala Phe Leu Leu Pro Leu Asn Gln Glu 
            100                 105                 110         


Asp Asn Thr Asn Leu Ala Arg Val Leu Thr Asn His Ile His Thr Gly 
        115                 120                 125             


His His Ser Ser Met Phe Trp Met Arg Val Pro Leu Val Ala Pro Glu 
    130                 135                 140                 


Asp Leu Arg Asp Asp Ile Ile Glu Asn Ala Pro Thr Thr His Thr Glu 
145                 150                 155                 160 


Glu Tyr Ser Gly Glu Glu Lys Thr Trp Met Trp Trp His Asn Phe Arg 
                165                 170                 175     


Thr Leu Cys Asp Tyr Ser Lys Arg Ile Ala Val Ala Leu Glu Ile Gly 
            180                 185                 190         


Ala Asp Leu Pro Ser Asn His Val Ile Asp Arg Trp Leu Gly Glu Pro 
        195                 200                 205             


Ile Lys Ala Ala Ile Leu Pro Thr Ser Ile Phe Leu Thr Asn Lys Lys 
    210                 215                 220                 


Gly Phe Pro Val Leu Ser Lys Met His Gln Arg Leu Ile Phe Arg Leu 
225                 230                 235                 240 


Leu Lys Leu Glu Val Gln Phe Ile Ile Thr Gly Thr Asn His His Ser 
                245                 250                 255     


Glu Lys Glu Phe Cys Ser Tyr Leu Gln Tyr Leu Glu Tyr Leu Ser Gln 
            260                 265                 270         


Asn Arg Pro Pro Pro Asn Ala Tyr Glu Leu Phe Ala Lys Gly Tyr Glu 
        275                 280                 285             


Asp Tyr Leu Gln Ser Pro Leu Gln Pro Leu Met Asp Asn Leu Glu Ser 
    290                 295                 300                 


Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro Ile Lys Tyr Ser Gln Tyr 
305                 310                 315                 320 


Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp Arg Val Pro Glu Glu Glu 
                325                 330                 335     


Lys Asp Thr Asn Val Gln Val Leu Met Val Leu Gly Ala Gly Arg Gly 
            340                 345                 350         


Pro Leu Val Asn Ala Ser Leu Arg Ala Ala Lys Gln Ala Asp Arg Arg 
        355                 360                 365             


Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro Asn Ala Val Val Thr Leu 
    370                 375                 380                 


Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser Gln Val Thr Val Val Ser 
385                 390                 395                 400 


Ser Asp Met Arg Glu Trp Val Ala Pro Glu Lys Ala Asp Ile Ile Val 
                405                 410                 415     


Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn Glu Leu Ser Pro Glu Cys 
            420                 425                 430         


Leu Asp Gly Ala Gln His Phe Leu Lys Asp Asp Gly Val Ser Ile Pro 
        435                 440                 445             


Gly Glu Tyr Thr Ser Phe Leu Ala Pro Ile Ser Ser Ser Lys Leu Tyr 
    450                 455                 460                 


Asn Glu Val Arg Ala Cys Arg Glu Lys Asp Arg Asp Pro Glu Ala Gln 
465                 470                 475                 480 


Phe Glu Met Pro Tyr Val Val Arg Leu His Asn Phe His Gln Leu Ser 
                485                 490                 495     


Ala Pro Gln Pro Cys Phe Thr Phe Ser His Pro Asn Arg Asp Pro Met 
            500                 505                 510         


Ile Asp Asn Asn Arg Tyr Cys Thr Leu Glu Phe Pro Val Glu Val Asn 
        515                 520                 525             


Thr Val Leu His Gly Phe Ala Gly Tyr Phe Glu Thr Val Leu Tyr Gln 
    530                 535                 540                 


Asp Ile Thr Leu Ser Ile Arg Pro Glu Thr His Ser Pro Gly Met Phe 
545                 550                 555                 560 


Ser Trp Phe Pro Ile Leu Phe Pro Ile Lys Gln Pro Ile Thr Val Arg 
                565                 570                 575     


Glu Gly Gln Thr Ile Cys Val Arg Phe Trp Arg Cys Ser Asn Ser Lys 
            580                 585                 590         


Lys Val Trp Tyr Glu Trp Ala Val Thr Ala Pro Val Cys Ser Ala Ile 
        595                 600                 605             


His Asn Pro Thr Gly Arg Ser Tyr Thr Ile Gly Leu 
    610                 615                 620 


<210> 6996
<211> 756
<212> PRT
<213> Homo sapiens

<400> 6996
Met Pro Ser Val Ser Lys Ala Ala Ala Ala Ala Leu Ser Gly Ser Pro 
1               5                   10                  15      


Pro Gln Thr Glu Lys Pro Thr His Tyr Arg Tyr Leu Lys Glu Phe Arg 
            20                  25                  30          


Thr Glu Gln Cys Pro Leu Phe Ser Gln His Lys Cys Ala Gln His Arg 
        35                  40                  45              


Pro Phe Thr Cys Phe His Trp His Phe Leu Asn Gln Arg Arg Arg Arg 
    50                  55                  60                  


Pro Leu Arg Arg Arg Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val Tyr 
65                  70                  75                  80  


Cys Ser Lys Tyr Asn Glu Ala Thr Gly Val Cys Pro Asp Gly Asp Glu 
                85                  90                  95      


Ser Leu Leu Gly Val Leu Tyr Pro Leu Trp Ala Pro Pro Pro Val Pro 
            100                 105                 110         


Ala Pro Val Gly Ala Pro Thr Val His Pro Phe Leu Ala Arg Trp Phe 
        115                 120                 125             


Ser His Val Pro Trp Glu Pro Ala Gly Ser Ala Asp Pro Arg Ala Ser 
    130                 135                 140                 


Ser Thr Pro Ala Gly Gly Thr Thr Trp Ala Thr Gly Leu Leu Gly Asp 
145                 150                 155                 160 


Phe Asp Ala Cys Gly Ser Gln Ser Arg Glu Cys Val Lys Gly Val Trp 
                165                 170                 175     


Trp Thr Leu Leu Gly Phe Arg Cys Pro Tyr Leu His Arg Thr Thr Gly 
            180                 185                 190         


Asp Thr Glu Arg Lys Tyr His Leu Arg Tyr Tyr Lys Thr Gly Thr Cys 
        195                 200                 205             


Ile His Glu Thr Asp Ala Arg Gly His Cys Val Lys Asn Gly Leu His 
    210                 215                 220                 


Cys Ala Phe Ala His Gly Pro Leu Asp Leu Arg Pro Pro Val Cys Asp 
225                 230                 235                 240 


Val Arg Glu Leu Gln Ala Gln Glu Ala Leu Gln Asn Gly Gln Leu Gly 
                245                 250                 255     


Gly Gly Glu Gly Val Pro Asp Leu Gln Pro Gly Val Leu Ala Ser Gln 
            260                 265                 270         


Ala Met Ile Glu Lys Ile Leu Ser Glu Asp Pro Arg Trp Gln Ala Leu 
        275                 280                 285             


Leu Pro Val Ala Leu Leu Arg His Arg Val Ala His Phe Ser Asp Ala 
    290                 295                 300                 


Asn Phe Val Leu Gly Ser Tyr Lys Thr Glu Gln Cys Pro Lys Pro Pro 
305                 310                 315                 320 


Arg Leu Cys Arg Gln Gly Tyr Ala Cys Pro His Tyr His Asn Ser Arg 
                325                 330                 335     


Asp Arg Arg Arg Asn Pro Arg Arg Phe Gln Tyr Arg Ser Thr Pro Cys 
            340                 345                 350         


Pro Ser Val Lys His Gly Asp Glu Trp Gly Glu Pro Ser Arg Cys Asp 
        355                 360                 365             


Gly Gly Asp Gly Cys Gln Tyr Cys His Ser Arg Thr Glu Gln Gln Phe 
    370                 375                 380                 


His Pro Glu Gly Pro Val Gly Ser Pro Val Ser Gly Ala Phe Ser Val 
385                 390                 395                 400 


Phe Ser His Ala Gly Leu Val Ala Asp Pro Ser Leu Trp Tyr Pro Ala 
                405                 410                 415     


Glu Trp Ser Trp His His Val Gly His Ser Arg Thr Ile Asn Pro Glu 
            420                 425                 430         


Gly Asp Lys Pro Ser Arg Leu Gly Pro Ala Pro Glu Asn Ile Lys Arg 
        435                 440                 445             


Gly Asn Asp Phe Ala Cys Asp Gly Arg Ala Asp Ala Ala Gly Met Ala 
    450                 455                 460                 


Pro His Val Cys Val Phe Pro Ile Tyr Lys Ser Thr Lys Cys Asn Asp 
465                 470                 475                 480 


Met Arg Gln Thr Gly Tyr Cys Pro Arg Gly Pro Phe Cys Ala Phe Ala 
                485                 490                 495     


His Val Glu Lys Ser Leu Gly Met Val Asn Glu Trp Gly Cys His Asp 
            500                 505                 510         


Leu His Leu Thr Ser Pro Ser Ser Thr Gly Ser Gly Gln Pro Gly Asn 
        515                 520                 525             


Ala Lys Arg Arg Asp Ser Pro Ala Glu Gly Gly Pro Arg Gly Ser Glu 
    530                 535                 540                 


Gln Asp Ser Lys Gln Gly Val Arg Ala His Gly Val Tyr Val Phe Glu 
545                 550                 555                 560 


Gln Asn His Leu Ala Val Phe Ala Ala Val His Pro Pro Ala Pro Ser 
                565                 570                 575     


Val Ser Ser Ser Val Ala Ser Ser Leu Ala Ser Ser Ala Gly Ser Gly 
            580                 585                 590         


Ser Ser Ser Pro Thr Ala Leu Pro Ala Pro Pro Ala Arg Ala Leu Pro 
        595                 600                 605             


Leu Gly Pro Ala Ser Ser Thr Val Glu Ala Val Leu Ala Leu Glu Pro 
    610                 615                 620                 


Thr Pro Ser Ser Pro Thr Ser Ser Ala Val Gln Gly Val Ala Gly Glu 
625                 630                 635                 640 


Leu Gly Met Gly Ser Gly Gly Gln Gly Cys Trp Ser His Val Val Gly 
                645                 650                 655     


Ala Leu Ala Ala Val Pro Ala Trp Thr His Ser Gly Asp Leu Glu Trp 
            660                 665                 670         


Asp Pro Ser Thr Ile Arg Thr Arg Val Asn Val Gly Gly Gly Pro Ala 
        675                 680                 685             


Ala Arg Pro Ala Met Thr Leu Ala Arg Glu Pro Gln Leu Leu Val Val 
    690                 695                 700                 


Gly Gly Cys Pro Thr Arg Asn Cys Ser Gly Pro Ala Ala Ser Pro Gln 
705                 710                 715                 720 


Gln Leu Leu Asp Asp Ala Gly Gln Gly Gly Arg Gly Glu Arg Asp Ser 
                725                 730                 735     


Ser Gln Arg Pro Leu Arg Pro Gln Thr Thr His Arg Gln Asp Thr Arg 
            740                 745                 750         


Pro Val Pro Ser 
        755     


<210> 6997
<211> 182
<212> PRT
<213> Homo sapiens

<400> 6997
Met Thr Pro Pro Gln Gln Pro Pro Pro Leu Arg Ser Glu Pro Gly Thr 
1               5                   10                  15      


Leu Gly Ser Ala Ala Ser Ser Tyr Ser Pro Leu Gly Leu Asn Gly Val 
            20                  25                  30          


Pro Gly Ser Ile Trp Asp Phe Val Ser Gly Ser Phe Ser Pro Ser Pro 
        35                  40                  45              


Ser Pro Ile Leu Ser Ala Gly Pro Pro Ser Ser Ser Ser Ala Ser Pro 
    50                  55                  60                  


Asn Gly Ala Glu Leu Ala Arg Val Arg Arg Gln Leu Asp Glu Ala Lys 
65                  70                  75                  80  


Arg Lys Ile Arg Gln Trp Glu Glu Ser Trp Gln Gln Val Lys Gln Val 
                85                  90                  95      


Cys Asp Ala Trp Gln Arg Glu Ala Gln Glu Ala Lys Glu Arg Ala Arg 
            100                 105                 110         


Val Ala Asp Ser Asp Arg Gln Leu Ala Leu Gln Lys Lys Glu Glu Val 
        115                 120                 125             


Glu Ala Gln Val Ile Phe Gln Leu Arg Ala Lys Gln Cys Val Ala Cys 
    130                 135                 140                 


Arg Glu Arg Ala His Gly Ala Val Leu Arg Pro Cys Gln His His Ile 
145                 150                 155                 160 


Leu Cys Glu Pro Cys Ala Ala Thr Ala Pro Glu Cys Pro Tyr Cys Lys 
                165                 170                 175     


Gly Gln Pro Leu Gln Trp 
            180         


<210> 6998
<211> 147
<212> PRT
<213> Homo sapiens

<400> 6998
Met Glu Gly Glu Pro Pro Pro Val Glu Glu Arg Arg Arg Leu Gln Glu 
1               5                   10                  15      


Glu Leu Asn Glu Phe Val Glu Ser Gly Cys Arg Thr Leu Glu Glu Val 
            20                  25                  30          


Thr Ala Ser Leu Gly Trp Asp Leu Asp Ser Leu Asp Pro Gly Glu Glu 
        35                  40                  45              


Glu Ala Ala Glu Asp Glu Val Val Ile Cys Pro Tyr Asp Ser Asn His 
    50                  55                  60                  


His Met Pro Lys Ser Ser Leu Ala Lys His Met Ala Ser Cys Arg Leu 
65                  70                  75                  80  


Arg Lys Met Gly Tyr Thr Lys Glu Glu Glu Asp Glu Met Tyr Asn Pro 
                85                  90                  95      


Glu Phe Phe Tyr Glu Asn Val Lys Ile Pro Ser Ile Thr Leu Asn Lys 
            100                 105                 110         


Asp Ser Gln Phe Gln Ile Ile Lys Gln Ala Arg Thr Ala Val Gly Lys 
        115                 120                 125             


Asp Ser Asp Cys Tyr Asn Gln Ile Ile Gly Val Ser Ile Lys Arg Asn 
    130                 135                 140                 


Tyr Lys Ile 
145         


<210> 6999
<211> 173
<212> PRT
<213> Homo sapiens

<400> 6999
Met Gly Thr Phe Asp Leu Trp Thr Asp Tyr Leu Gly Leu Ala His Leu 
1               5                   10                  15      


Val Arg Ala Leu Ser Gly Lys Glu Gly Pro Glu Thr Arg Leu Ser Pro 
            20                  25                  30          


Gln Pro Glu Pro Glu Pro Met Leu Glu Pro Asp Gln Lys Arg Ser Leu 
        35                  40                  45              


Glu Ser Ser Pro Ala Pro Glu Arg Leu Cys Ser Phe Cys Lys His Asn 
    50                  55                  60                  


Gly Glu Ser Arg Ala Ile Tyr Gln Ser His Val Leu Lys Asp Glu Ala 
65                  70                  75                  80  


Gly Arg Val Leu Cys Pro Ile Leu Arg Asp Tyr Val Cys Pro Gln Cys 
                85                  90                  95      


Gly Ala Thr Arg Glu Arg Ala His Thr Arg Arg Phe Cys Pro Leu Thr 
            100                 105                 110         


Gly Gln Gly Tyr Thr Ser Val Tyr Ser His Thr Thr Arg Asn Ser Ala 
        115                 120                 125             


Gly Lys Lys Leu Val Arg Pro Asp Lys Ala Lys Thr Gln Asp Thr Gly 
    130                 135                 140                 


His Arg Arg Gly Gly Gly Gly Gly Ala Gly Phe Arg Gly Ala Gly Lys 
145                 150                 155                 160 


Ser Glu Pro Ser Pro Ser Cys Ser Pro Ser Met Ser Thr 
                165                 170             


<210> 7000
<211> 573
<212> PRT
<213> Homo sapiens

<400> 7000
Met Ser Ala Phe Cys Leu Gly Leu Val Gly Arg Ala Ser Ala Pro Ala 
1               5                   10                  15      


Glu Pro Asp Ser Ala Cys Cys Met Glu Leu Pro Ala Ala Ala Gly Asp 
            20                  25                  30          


Ala Val Arg Ser Pro Ala Ala Ala Ala Ala Leu Ile Phe Pro Gly Gly 
        35                  40                  45              


Ser Gly Glu Leu Glu Leu Ala Leu Glu Glu Glu Leu Ala Leu Leu Ala 
    50                  55                  60                  


Ala Gly Glu Arg Pro Ser Asp Pro Gly Glu His Pro Gln Ala Glu Pro 
65                  70                  75                  80  


Gly Ser Leu Ala Glu Gly Ala Gly Pro Gln Pro Pro Pro Ser Gln Asp 
                85                  90                  95      


Pro Glu Leu Leu Ser Val Ile Arg Gln Lys Glu Lys Asp Leu Val Leu 
            100                 105                 110         


Ala Ala Arg Leu Gly Lys Ala Leu Leu Glu Arg Asn Gln Asp Met Ser 
        115                 120                 125             


Arg Gln Tyr Glu Gln Met His Lys Glu Leu Thr Asp Lys Leu Glu His 
    130                 135                 140                 


Leu Glu Gln Glu Lys His Glu Leu Arg Arg Arg Phe Glu Asn Arg Glu 
145                 150                 155                 160 


Gly Glu Trp Glu Gly Arg Val Ser Glu Leu Glu Ser Asp Val Lys Gln 
                165                 170                 175     


Leu Gln Asp Glu Leu Glu Arg Gln Gln Ile His Leu Arg Glu Ala Asp 
            180                 185                 190         


Arg Glu Lys Ser Arg Ala Val Gln Glu Leu Ser Glu Gln Asn Gln Arg 
        195                 200                 205             


Leu Leu Asp Gln Leu Ser Arg Ala Ser Glu Val Glu Arg Gln Leu Ser 
    210                 215                 220                 


Met Gln Val His Ala Leu Arg Glu Asp Phe Arg Glu Lys Asn Ser Ser 
225                 230                 235                 240 


Thr Asn Gln His Ile Ile Arg Leu Glu Ser Leu Gln Ala Glu Ile Lys 
                245                 250                 255     


Met Leu Ser Asp Arg Lys Arg Glu Leu Glu His Arg Leu Ser Ala Thr 
            260                 265                 270         


Leu Glu Glu Asn Asp Leu Leu Gln Gly Thr Val Glu Glu Leu Gln Asp 
        275                 280                 285             


Arg Val Leu Ile Leu Glu Arg Gln Gly His Asp Lys Asp Leu Gln Leu 
    290                 295                 300                 


His Gln Ser Gln Leu Glu Leu Gln Glu Val Arg Leu Ser Cys Arg Gln 
305                 310                 315                 320 


Leu Gln Val Lys Val Glu Glu Leu Thr Glu Glu Arg Ser Leu Gln Ser 
                325                 330                 335     


Ser Ala Ala Thr Ser Thr Ser Leu Leu Ser Glu Ile Glu Gln Ser Met 
            340                 345                 350         


Glu Ala Glu Glu Leu Glu Gln Glu Arg Glu Gln Leu Arg Leu Gln Leu 
        355                 360                 365             


Trp Glu Ala Tyr Cys Gln Val Arg Tyr Leu Cys Ser His Leu Arg Gly 
    370                 375                 380                 


Asn Asp Ser Ala Asp Ser Ala Val Ser Thr Asp Ser Ser Met Asp Glu 
385                 390                 395                 400 


Ser Ser Glu Thr Ser Ser Ala Lys Asp Val Pro Ala Gly Ser Leu Arg 
                405                 410                 415     


Thr Ala Leu Asn Glu Leu Lys Arg Leu Ile Gln Ser Ile Val Asp Gly 
            420                 425                 430         


Met Glu Pro Thr Val Thr Leu Leu Ser Val Glu Met Thr Ala Leu Lys 
        435                 440                 445             


Glu Glu Arg Asp Arg Leu Arg Val Thr Ser Glu Asp Lys Glu Pro Lys 
    450                 455                 460                 


Glu Gln Leu Gln Lys Ala Ile Arg Asp Arg Asp Glu Ala Ile Ala Lys 
465                 470                 475                 480 


Lys Asn Ala Val Glu Leu Glu Leu Ala Lys Cys Arg Met Asp Met Met 
                485                 490                 495     


Ser Leu Asn Ser Gln Leu Leu Asp Ala Ile Gln Gln Lys Leu Asn Leu 
            500                 505                 510         


Ser Gln Gln Leu Glu Ala Trp Gln Asp Asp Met His Arg Val Ile Asp 
        515                 520                 525             


Arg Gln Leu Met Asp Thr His Leu Lys Glu Arg Ser Gln Pro Ala Ala 
    530                 535                 540                 


Ala Leu Cys Arg Gly His Ser Ala Gly Arg Gly Asp Glu Pro Ser Ile 
545                 550                 555                 560 


Ala Glu Gly Lys Arg Leu Phe Ser Phe Phe Arg Lys Ile 
                565                 570             


<210> 7001
<211> 361
<212> PRT
<213> Homo sapiens

<400> 7001
Met Ala Leu Asn Val Ala Pro Val Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Gln Phe Gln Arg Gly Thr Cys Ser Arg Ser Asp Glu 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Pro Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Thr His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Thr Ala Ala Ala Met 
                85                  90                  95      


Leu Ala Gln Gln Met Gln Phe Met Phe Pro Gly Thr Pro Leu His Pro 
            100                 105                 110         


Val Pro Thr Phe Pro Val Gly Pro Ala Ile Gly Thr Asn Thr Ala Ile 
        115                 120                 125             


Ser Phe Ala Pro Tyr Leu Ala Pro Val Thr Pro Gly Val Gly Leu Val 
    130                 135                 140                 


Pro Thr Glu Ile Leu Pro Thr Thr Pro Val Ile Val Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Val Thr Val Pro Gly Ser Thr Ala Thr Gln Lys Leu Leu Arg Thr 
                165                 170                 175     


Asp Lys Leu Glu Val Cys Arg Glu Phe Gln Arg Gly Asn Cys Ala Arg 
            180                 185                 190         


Gly Glu Thr Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile 
        195                 200                 205             


Asp Thr Ser Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly 
    210                 215                 220                 


Arg Cys Met Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu 
225                 230                 235                 240 


Gln Ala Lys Ile Lys Ala Ala Gln His Gln Ala Asn Gln Ala Ala Val 
                245                 250                 255     


Ala Ala Gln Ala Ala Ala Ala Ala Ala Thr Val Met Ala Phe Pro Pro 
            260                 265                 270         


Gly Ala Leu His Pro Leu Pro Lys Arg Gln Ala Leu Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ser Ala Val Phe Asn Pro Ser Val Leu His Tyr Gln Gln Ala 
    290                 295                 300                 


Leu Thr Ser Ala Gln Leu Gln Gln His Ala Ala Phe Ile Pro Thr Asp 
305                 310                 315                 320 


Asn Ser Glu Ile Ile Ser Arg Asn Gly Met Glu Cys Gln Glu Ser Ala 
                325                 330                 335     


Leu Arg Ile Thr Lys His Cys Tyr Cys Thr Tyr Tyr Pro Val Ser Ser 
            340                 345                 350         


Ser Ile Glu Leu Pro Gln Thr Ala Cys 
        355                 360     


<210> 7002
<211> 1032
<212> PRT
<213> Homo sapiens

<400> 7002
Met Ala Phe Thr Asn Tyr Ser Ser Leu Asn Arg Ala Gln Leu Thr Phe 
1               5                   10                  15      


Glu Tyr Leu His Thr Asn Ser Thr Thr His Glu Phe Leu Phe Gly Ala 
            20                  25                  30          


Leu Ala Glu Leu Val Asp Asn Ala Arg Asp Ala Asp Ala Thr Arg Ile 
        35                  40                  45              


Asp Ile Tyr Ala Glu Arg Arg Glu Asp Leu Arg Gly Gly Phe Met Leu 
    50                  55                  60                  


Cys Phe Leu Asp Asp Gly Ala Gly Met Asp Pro Ser Asp Ala Ala Ser 
65                  70                  75                  80  


Val Ile Gln Phe Gly Lys Ser Ala Lys Arg Thr Pro Glu Ser Thr Gln 
                85                  90                  95      


Ile Gly Gln Tyr Gly Asn Gly Leu Lys Ser Gly Ser Met Arg Ile Gly 
            100                 105                 110         


Lys Asp Phe Ile Leu Phe Thr Lys Lys Glu Asp Thr Met Thr Cys Leu 
        115                 120                 125             


Phe Leu Ser Arg Thr Phe His Glu Glu Glu Gly Ile Asp Glu Val Ile 
    130                 135                 140                 


Val Pro Leu Pro Thr Trp Asn Ala Arg Thr Arg Glu Pro Val Thr Asp 
145                 150                 155                 160 


Asn Val Glu Lys Phe Ala Ile Glu Thr Glu Leu Ile Tyr Lys Tyr Ser 
                165                 170                 175     


Pro Phe Arg Thr Glu Glu Glu Val Met Thr Gln Phe Met Lys Ile Pro 
            180                 185                 190         


Gly Asp Ser Gly Thr Leu Val Ile Ile Phe Asn Leu Lys Leu Met Asp 
        195                 200                 205             


Asn Gly Glu Pro Glu Leu Asp Ile Ile Ser Asn Pro Arg Asp Ile Gln 
    210                 215                 220                 


Met Ala Glu Thr Ser Pro Glu Gly Thr Lys Pro Glu Arg Arg Ser Phe 
225                 230                 235                 240 


Arg Ala Tyr Ala Ala Val Leu Tyr Ile Asp Pro Arg Met Arg Ile Phe 
                245                 250                 255     


Ile His Gly His Lys Val Gln Thr Lys Arg Leu Ser Cys Cys Leu Tyr 
            260                 265                 270         


Lys Pro Arg Met Tyr Lys Tyr Thr Ser Ser Arg Phe Lys Thr Arg Ala 
        275                 280                 285             


Glu Gln Glu Val Lys Lys Ala Glu His Val Ala Arg Ile Ala Glu Glu 
    290                 295                 300                 


Lys Ala Arg Glu Ala Glu Ser Lys Ala Arg Thr Leu Glu Val Arg Leu 
305                 310                 315                 320 


Gly Gly Asp Leu Thr Arg Asp Ser Arg Val Met Leu Arg Gln Val Gln 
                325                 330                 335     


Asn Arg Ala Ile Thr Leu Arg Arg Glu Ala Asp Val Lys Lys Arg Ile 
            340                 345                 350         


Lys Glu Ala Lys Gln Arg Ala Leu Lys Glu Pro Lys Glu Leu Asn Phe 
        355                 360                 365             


Val Phe Gly Val Asn Ile Glu His Arg Asp Leu Asp Gly Met Phe Ile 
    370                 375                 380                 


Tyr Asn Cys Ser Arg Leu Ile Lys Met Tyr Glu Lys Val Gly Pro Gln 
385                 390                 395                 400 


Leu Glu Gly Gly Met Ala Cys Gly Gly Val Val Gly Val Val Asp Val 
                405                 410                 415     


Pro Tyr Leu Val Leu Glu Pro Thr His Asn Lys Gln Asp Phe Ala Asp 
            420                 425                 430         


Ala Lys Glu Tyr Arg His Leu Leu Arg Ala Met Gly Glu His Leu Ala 
        435                 440                 445             


Gln Tyr Trp Lys Asp Ile Ala Ile Ala Gln Arg Gly Ile Ile Lys Phe 
    450                 455                 460                 


Trp Asp Glu Phe Gly Tyr Leu Ser Ala Asn Trp Asn Gln Pro Pro Ser 
465                 470                 475                 480 


Ser Glu Leu Arg Tyr Lys Arg Arg Arg Ala Met Glu Ile Pro Thr Thr 
                485                 490                 495     


Ile Gln Cys Asp Leu Cys Leu Lys Trp Arg Thr Leu Pro Phe Gln Leu 
            500                 505                 510         


Ser Ser Val Glu Lys Asp Tyr Pro Asp Thr Trp Val Cys Ser Met Asn 
        515                 520                 525             


Pro Asp Pro Glu Gln Asp Arg Cys Glu Ala Ser Glu Gln Lys Gln Lys 
    530                 535                 540                 


Val Pro Leu Gly Thr Phe Arg Lys Asp Met Lys Thr Gln Glu Glu Lys 
545                 550                 555                 560 


Gln Lys Gln Leu Thr Glu Lys Ile Arg Gln Gln Gln Glu Lys Leu Glu 
                565                 570                 575     


Ala Leu Gln Lys Thr Thr Pro Ile Arg Ser Gln Ala Asp Leu Lys Lys 
            580                 585                 590         


Leu Pro Leu Glu Val Thr Thr Arg Pro Ser Thr Glu Glu Pro Val Arg 
        595                 600                 605             


Arg Pro Gln Arg Pro Arg Ser Pro Pro Leu Pro Ala Val Ile Arg Asn 
    610                 615                 620                 


Ala Pro Ser Arg Pro Pro Ser Leu Pro Thr Pro Arg Pro Ala Ser Gln 
625                 630                 635                 640 


Pro Arg Lys Ala Pro Val Ile Ser Ser Thr Pro Lys Leu Pro Ala Leu 
                645                 650                 655     


Ala Ala Arg Glu Glu Ala Ser Thr Ser Arg Leu Leu Gln Pro Pro Glu 
            660                 665                 670         


Ala Pro Arg Lys Pro Ala Asn Thr Leu Val Lys Thr Ala Ser Arg Pro 
        675                 680                 685             


Ala Pro Leu Val Gln Gln Leu Ser Pro Ser Leu Leu Pro Asn Ser Lys 
    690                 695                 700                 


Ser Pro Arg Glu Val Pro Ser Pro Lys Val Ile Lys Thr Pro Val Val 
705                 710                 715                 720 


Lys Lys Thr Glu Ser Pro Ile Lys Leu Ser Pro Ala Thr Pro Ser Arg 
                725                 730                 735     


Lys Arg Ser Val Ala Val Ser Asp Glu Glu Glu Val Glu Glu Glu Ala 
            740                 745                 750         


Glu Arg Arg Lys Glu Arg Cys Lys Arg Gly Arg Phe Val Val Lys Glu 
        755                 760                 765             


Glu Lys Lys Asp Ser Asn Glu Leu Ser Asp Ser Ala Gly Glu Glu Asp 
    770                 775                 780                 


Ser Ala Asp Leu Lys Arg Ala Gln Lys Asp Lys Gly Leu His Val Glu 
785                 790                 795                 800 


Val Arg Val Asn Arg Glu Trp Tyr Thr Gly Arg Val Thr Ala Val Glu 
                805                 810                 815     


Val Gly Lys His Val Val Arg Trp Lys Val Lys Phe Asp Tyr Val Pro 
            820                 825                 830         


Thr Asp Thr Thr Pro Arg Asp Arg Trp Val Glu Lys Gly Ser Glu Asp 
        835                 840                 845             


Val Arg Leu Met Lys Pro Pro Ser Pro Glu His Gln Ser Leu Asp Thr 
    850                 855                 860                 


Gln Gln Glu Gly Gly Glu Glu Glu Val Gly Pro Val Ala Gln Gln Ala 
865                 870                 875                 880 


Ile Ala Val Ala Glu Pro Ser Thr Ser Glu Cys Leu Arg Ile Glu Pro 
                885                 890                 895     


Asp Thr Thr Ala Leu Ser Thr Asn His Glu Thr Ile Asp Leu Leu Val 
            900                 905                 910         


Gln Ile Leu Arg Asn Cys Leu Arg Tyr Phe Leu Pro Pro Ser Phe Pro 
        915                 920                 925             


Ile Ser Lys Lys Gln Leu Ser Ala Met Asn Ser Asp Glu Leu Ile Ser 
    930                 935                 940                 


Phe Pro Leu Lys Glu Tyr Phe Lys Gln Tyr Glu Val Gly Leu Gln Asn 
945                 950                 955                 960 


Leu Cys Asn Ser Tyr Gln Ser Arg Ala Asp Ser Arg Ala Lys Ala Ser 
                965                 970                 975     


Glu Glu Ser Leu Arg Thr Ser Glu Arg Lys Leu Arg Glu Thr Glu Glu 
            980                 985                 990         


Lys Leu Gln Lys Leu Arg Thr Asn  Ile Val Ala Leu Leu  Gln Lys Val 
        995                 1000                 1005             


Gln Glu  Asp Ile Asp Ile Asn  Thr Asp Asp Glu Leu  Asp Ala Tyr 
    1010                 1015                 1020             


Ile Glu  Asp Leu Ile Thr Lys  Gly Asp 
    1025                 1030         


<210> 7003
<211> 1980
<212> PRT
<213> Homo sapiens

<400> 7003
Met Asn Pro Thr Asn Pro Phe Ser Gly Gln Gln Pro Ser Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ser Ser Asn Val Gly Thr Leu Pro Ser Lys Pro Pro Phe Arg 
            20                  25                  30          


Phe Gly Gln Pro Ser Leu Phe Gly Gln Asn Ser Thr Leu Ser Gly Lys 
        35                  40                  45              


Ser Ser Gly Phe Ser Gln Val Ser Ser Phe Pro Ala Ser Ser Gly Val 
    50                  55                  60                  


Ser His Ser Ser Ser Val Gln Thr Leu Gly Phe Thr Gln Thr Ser Ser 
65                  70                  75                  80  


Val Gly Pro Phe Ser Gly Leu Glu His Thr Ser Thr Phe Val Ala Thr 
                85                  90                  95      


Ser Gly Pro Ser Ser Ser Ser Val Leu Gly Asn Thr Gly Phe Ser Phe 
            100                 105                 110         


Lys Ser Pro Thr Ser Val Gly Ala Phe Pro Ser Thr Ser Ala Phe Gly 
        115                 120                 125             


Gln Glu Ala Gly Glu Ile Val Asn Ser Gly Phe Gly Lys Thr Glu Phe 
    130                 135                 140                 


Ser Phe Lys Pro Leu Glu Asn Ala Val Phe Lys Pro Ile Leu Gly Ala 
145                 150                 155                 160 


Glu Ser Glu Pro Glu Lys Thr Gln Ser Gln Ile Ala Ser Gly Phe Phe 
                165                 170                 175     


Thr Phe Ser His Pro Ile Ser Ser Ala Pro Gly Gly Leu Ala Pro Phe 
            180                 185                 190         


Ser Phe Pro Gln Val Thr Ser Ser Ser Ala Thr Thr Ser Asn Phe Thr 
        195                 200                 205             


Phe Ser Lys Pro Val Ser Ser Asn Asn Ser Leu Ser Ala Phe Thr Pro 
    210                 215                 220                 


Ala Leu Ser Asn Gln Asn Val Glu Glu Glu Lys Arg Gly Pro Lys Ser 
225                 230                 235                 240 


Ile Phe Gly Ser Ser Asn Asn Ser Phe Ser Ser Phe Pro Val Ser Ser 
                245                 250                 255     


Ala Val Leu Gly Glu Pro Phe Gln Ala Ser Lys Ala Gly Val Arg Gln 
            260                 265                 270         


Gly Cys Glu Glu Ala Val Ser Gln Val Glu Pro Leu Pro Ser Leu Met 
        275                 280                 285             


Lys Gly Leu Lys Arg Lys Glu Asp Gln Asp Arg Ser Pro Arg Arg His 
    290                 295                 300                 


Gly His Glu Pro Ala Glu Asp Ser Asp Pro Leu Ser Arg Gly Asp His 
305                 310                 315                 320 


Pro Pro Asp Lys Arg Pro Val Arg Leu Asn Arg Pro Arg Gly Gly Thr 
                325                 330                 335     


Leu Phe Gly Arg Thr Ile Gln Asp Val Phe Lys Ser Asn Lys Glu Val 
            340                 345                 350         


Gly Arg Leu Gly Asn Lys Glu Ala Lys Lys Glu Thr Gly Phe Val Glu 
        355                 360                 365             


Ser Ala Glu Ser Asp His Met Ala Ile Pro Gly Gly Asn Gln Ser Val 
    370                 375                 380                 


Leu Ala Pro Ser Arg Ile Pro Gly Val Asn Lys Glu Glu Glu Thr Glu 
385                 390                 395                 400 


Ser Arg Glu Lys Lys Glu Asp Ser Leu Arg Gly Thr Pro Ala Arg Gln 
                405                 410                 415     


Ser Asn Arg Ser Glu Ser Thr Asp Ser Leu Gly Gly Leu Ser Pro Ser 
            420                 425                 430         


Glu Val Thr Ala Ile Gln Cys Lys Asn Ile Pro Asp Tyr Leu Asn Asp 
        435                 440                 445             


Arg Thr Ile Leu Glu Asn His Phe Gly Lys Ile Ala Lys Val Gln Arg 
    450                 455                 460                 


Ile Phe Thr Arg Arg Ser Lys Lys Leu Ala Val Val His Phe Phe Asp 
465                 470                 475                 480 


His Ala Ser Ala Ala Leu Ala Arg Lys Lys Gly Lys Ser Leu His Lys 
                485                 490                 495     


Asp Met Ala Ile Phe Trp His Arg Lys Lys Ile Ser Pro Asn Lys Lys 
            500                 505                 510         


Pro Phe Ser Leu Lys Glu Lys Lys Pro Gly Asp Gly Glu Val Ser Pro 
        515                 520                 525             


Ser Thr Glu Asp Ala Pro Phe Gln His Ser Pro Leu Gly Lys Ala Ala 
    530                 535                 540                 


Gly Arg Thr Gly Ala Ser Ser Leu Leu Asn Lys Ser Ser Pro Val Lys 
545                 550                 555                 560 


Lys Pro Ser Leu Leu Lys Ala His Gln Phe Glu Gly Asp Ser Phe Asp 
                565                 570                 575     


Ser Ala Ser Glu Gly Ser Glu Gly Leu Gly Pro Cys Val Leu Ser Leu 
            580                 585                 590         


Ser Thr Leu Ile Gly Thr Val Ala Glu Thr Ser Lys Glu Lys Tyr Arg 
        595                 600                 605             


Leu Leu Asp Gln Arg Asp Arg Ile Met Arg Gln Ala Arg Val Lys Arg 
    610                 615                 620                 


Thr Asp Leu Asp Lys Ala Arg Thr Phe Val Gly Thr Cys Leu Asp Met 
625                 630                 635                 640 


Cys Pro Glu Lys Glu Arg Tyr Met Arg Glu Thr Arg Ser Gln Leu Ser 
                645                 650                 655     


Val Phe Glu Val Val Pro Gly Thr Asp Gln Val Asp His Ala Ala Ala 
            660                 665                 670         


Val Lys Glu Tyr Ser Arg Ser Ser Ala Asp Gln Glu Glu Pro Leu Pro 
        675                 680                 685             


His Glu Leu Arg Pro Leu Pro Val Leu Ser Arg Thr Met Asp Tyr Leu 
    690                 695                 700                 


Val Thr Gln Ile Met Asp Gln Lys Glu Gly Ser Leu Arg Asp Trp Tyr 
705                 710                 715                 720 


Asp Phe Val Trp Asn Arg Thr Arg Gly Ile Arg Lys Asp Ile Thr Gln 
                725                 730                 735     


Gln His Leu Cys Asp Pro Leu Thr Val Ser Leu Ile Glu Lys Cys Thr 
            740                 745                 750         


Arg Phe His Ile His Cys Ala His Phe Met Cys Glu Glu Pro Met Ser 
        755                 760                 765             


Ser Phe Asp Ala Lys Ile Asn Asn Glu Asn Met Thr Lys Cys Leu Gln 
    770                 775                 780                 


Ser Leu Lys Glu Met Tyr Gln Asp Leu Arg Asn Lys Gly Val Phe Cys 
785                 790                 795                 800 


Ala Ser Glu Ala Glu Phe Gln Gly Tyr Asn Val Leu Leu Ser Leu Asn 
                805                 810                 815     


Lys Gly Asp Ile Leu Arg Glu Val Gln Gln Phe His Pro Ala Val Arg 
            820                 825                 830         


Asn Ser Ser Glu Val Lys Phe Ala Val Gln Ala Phe Ala Ala Leu Asn 
        835                 840                 845             


Ser Asn Asn Phe Val Arg Phe Phe Lys Leu Val Gln Ser Ala Ser Tyr 
    850                 855                 860                 


Leu Asn Ala Cys Leu Leu His Cys Tyr Phe Ser Gln Ile Arg Lys Asp 
865                 870                 875                 880 


Ala Leu Arg Ala Leu Asn Phe Ala Tyr Thr Val Ser Thr Gln Arg Ser 
                885                 890                 895     


Thr Ile Phe Pro Leu Asp Gly Val Val Arg Met Leu Leu Phe Arg Asp 
            900                 905                 910         


Cys Glu Glu Ala Thr Asp Phe Leu Thr Cys His Gly Leu Thr Val Ser 
        915                 920                 925             


Asp Gly Cys Val Glu Leu Asn Arg Ser Ala Phe Leu Glu Pro Glu Gly 
    930                 935                 940                 


Leu Ser Lys Thr Arg Lys Ser Val Phe Ile Thr Arg Lys Leu Thr Val 
945                 950                 955                 960 


Ser Val Gly Glu Ile Val Asn Gly Gly Pro Leu Pro Pro Val Pro Arg 
                965                 970                 975     


His Thr Pro Val Cys Ser Phe Asn Ser Gln Asn Lys Tyr Ile Gly Glu 
            980                 985                 990         


Ser Leu Ala Ala Glu Leu Pro Val  Ser Thr Gln Arg Pro  Gly Ser Asp 
        995                 1000                 1005             


Thr Val  Gly Gly Gly Arg Gly  Glu Glu Cys Gly Val  Glu Pro Asp 
    1010                 1015                 1020             


Ala Pro  Leu Ser Ser Leu Pro  Gln Ser Leu Pro Ala  Pro Ala Pro 
    1025                 1030                 1035             


Ser Pro  Val Pro Leu Pro Pro  Val Leu Ala Leu Thr  Pro Ser Val 
    1040                 1045                 1050             


Ala Pro  Ser Leu Phe Gln Leu  Ser Val Gln Pro Glu  Pro Pro Pro 
    1055                 1060                 1065             


Pro Glu  Pro Val Pro Met Tyr  Ser Asp Glu Asp Leu  Ala Gln Val 
    1070                 1075                 1080             


Val Asp  Glu Leu Ile Gln Glu  Ala Leu Gln Arg Asp  Cys Glu Glu 
    1085                 1090                 1095             


Val Gly  Ser Ala Gly Ala Ala  Tyr Ala Ala Ala Ala  Leu Gly Val 
    1100                 1105                 1110             


Ser Asn  Ala Ala Met Glu Asp  Leu Leu Thr Ala Ala  Thr Thr Gly 
    1115                 1120                 1125             


Ile Leu  Arg His Ile Ala Ala  Glu Glu Val Ser Lys  Glu Arg Glu 
    1130                 1135                 1140             


Arg Arg  Glu Gln Glu Arg Gln  Arg Ala Glu Glu Glu  Arg Leu Lys 
    1145                 1150                 1155             


Gln Glu  Arg Glu Leu Val Leu  Ser Glu Leu Ser Gln  Gly Leu Ala 
    1160                 1165                 1170             


Val Glu  Leu Met Glu Arg Val  Met Met Glu Phe Val  Arg Glu Thr 
    1175                 1180                 1185             


Cys Ser  Gln Glu Leu Lys Asn  Ala Val Glu Thr Asp  Gln Arg Val 
    1190                 1195                 1200             


Arg Val  Ala Arg Cys Cys Glu  Asp Val Cys Ala His  Leu Val Asp 
    1205                 1210                 1215             


Leu Phe  Leu Val Glu Glu Ile  Phe Gln Thr Ala Lys  Glu Thr Leu 
    1220                 1225                 1230             


Gln Glu  Leu Gln Cys Phe Cys  Lys Tyr Leu Gln Arg  Trp Arg Glu 
    1235                 1240                 1245             


Ala Val  Thr Ala Arg Lys Lys  Leu Arg Arg Gln Met  Arg Ala Phe 
    1250                 1255                 1260             


Pro Ala  Ala Pro Cys Cys Val  Asp Val Ser Asp Arg  Leu Arg Ala 
    1265                 1270                 1275             


Leu Ala  Pro Ser Ala Glu Cys  Pro Ile Ala Glu Glu  Asn Leu Ala 
    1280                 1285                 1290             


Arg Gly  Leu Leu Asp Leu Gly  His Ala Gly Arg Leu  Gly Ile Ser 
    1295                 1300                 1305             


Cys Thr  Arg Leu Arg Arg Leu  Arg Asn Lys Thr Ala  His Gln Met 
    1310                 1315                 1320             


Lys Val  Gln His Phe Tyr Gln  Gln Leu Leu Ser Asp  Val Ala Trp 
    1325                 1330                 1335             


Ala Ser  Leu Asp Leu Pro Ser  Leu Val Ala Glu His  Leu Pro Gly 
    1340                 1345                 1350             


Arg Gln  Glu His Val Phe Trp  Lys Leu Val Leu Val  Leu Pro Asp 
    1355                 1360                 1365             


Val Glu  Glu Gln Ser Pro Glu  Ser Cys Gly Arg Ile  Leu Ala Asn 
    1370                 1375                 1380             


Trp Leu  Lys Val Lys Phe Met  Gly Asp Glu Gly Ser  Val Asp Asp 
    1385                 1390                 1395             


Thr Ser  Ser Asp Ala Gly Gly  Ile Gln Thr Leu Ser  Leu Phe Asn 
    1400                 1405                 1410             


Ser Leu  Ser Ser Lys Gly Asp  Gln Met Ile Ser Val  Asn Val Cys 
    1415                 1420                 1425             


Ile Lys  Val Ala His Gly Ala  Leu Ser Asp Gly Ala  Ile Asp Ala 
    1430                 1435                 1440             


Val Glu  Thr Gln Lys Asp Leu  Leu Gly Ala Ser Gly  Leu Met Leu 
    1445                 1450                 1455             


Leu Leu  Pro Pro Lys Met Lys  Ser Glu Asp Met Ala  Glu Glu Asp 
    1460                 1465                 1470             


Val Tyr  Trp Leu Ser Ala Leu  Leu Gln Leu Lys Gln  Leu Leu Gln 
    1475                 1480                 1485             


Ala Lys  Pro Phe Gln Pro Ala  Leu Pro Leu Val Val  Leu Val Pro 
    1490                 1495                 1500             


Ser Pro  Gly Gly Asp Ala Val  Glu Lys Glu Val Glu  Asp Gly Leu 
    1505                 1510                 1515             


Met Leu  Gln Asp Leu Val Ser  Ala Lys Leu Ile Ser  Asp Tyr Thr 
    1520                 1525                 1530             


Val Thr  Glu Ile Pro Asp Thr  Ile Asn Asp Leu Gln  Gly Ser Thr 
    1535                 1540                 1545             


Lys Val  Leu Gln Ala Val Gln  Trp Leu Val Ser His  Cys Pro His 
    1550                 1555                 1560             


Ser Leu  Asp Leu Cys Cys Gln  Thr Leu Ile Gln Tyr  Val Glu Asp 
    1565                 1570                 1575             


Gly Ile  Gly His Glu Phe Ser  Gly Arg Phe Phe His  Asp Arg Arg 
    1580                 1585                 1590             


Glu Arg  Arg Leu Gly Gly Leu  Ala Ser Gln Glu Pro  Gly Ala Ile 
    1595                 1600                 1605             


Ile Glu  Leu Phe Asn Ser Val  Leu Gln Phe Leu Ala  Ser Val Val 
    1610                 1615                 1620             


Ser Ser  Glu Gln Leu Cys Asp  Leu Ser Trp Pro Val  Thr Glu Phe 
    1625                 1630                 1635             


Ala Glu  Ala Gly Gly Ser Arg  Leu Leu Pro His Leu  His Trp Asn 
    1640                 1645                 1650             


Ala Pro  Glu His Leu Ala Trp  Leu Lys Gln Ala Val  Leu Gly Phe 
    1655                 1660                 1665             


Gln Leu  Pro Gln Met Asp Leu  Pro Pro Leu Gly Ala  Pro Trp Leu 
    1670                 1675                 1680             


Pro Val  Cys Ser Met Val Val  Gln Tyr Ala Ser Gln  Ile Pro Ser 
    1685                 1690                 1695             


Ser Arg  Gln Thr Gln Pro Val  Leu Gln Ser Gln Val  Glu Asn Leu 
    1700                 1705                 1710             


Leu His  Arg Thr Tyr Cys Arg  Trp Lys Ser Lys Ser  Pro Ser Pro 
    1715                 1720                 1725             


Val His  Gly Ala Gly Pro Ser  Val Met Glu Ile Pro  Trp Asp Asp 
    1730                 1735                 1740             


Leu Ile  Ala Leu Cys Ile Asn  His Lys Leu Arg Asp  Trp Thr Pro 
    1745                 1750                 1755             


Pro Arg  Leu Pro Val Thr Ser  Glu Ala Leu Ser Glu  Asp Gly Gln 
    1760                 1765                 1770             


Ile Cys  Val Tyr Phe Phe Lys  Asn Asp Leu Lys Lys  Tyr Asp Val 
    1775                 1780                 1785             


Pro Leu  Ser Trp Glu Gln Ala  Arg Leu Gln Thr Gln  Lys Glu Leu 
    1790                 1795                 1800             


Gln Leu  Arg Glu Gly Arg Leu  Ala Ile Lys Pro Phe  His Pro Ser 
    1805                 1810                 1815             


Ala Asn  Asn Phe Pro Ile Pro  Leu Leu His Met His  Arg Asn Trp 
    1820                 1825                 1830             


Lys Arg  Ser Thr Glu Cys Ala  Gln Glu Gly Arg Ile  Pro Ser Thr 
    1835                 1840                 1845             


Glu Asp  Leu Met Arg Gly Ala  Ser Ala Glu Glu Leu  Leu Ala Gln 
    1850                 1855                 1860             


Cys Leu  Ser Ser Ser Leu Leu  Leu Glu Lys Glu Glu  Asn Lys Arg 
    1865                 1870                 1875             


Phe Glu  Asp Gln Leu Gln Gln  Trp Leu Ser Glu Asp  Ser Gly Ala 
    1880                 1885                 1890             


Phe Thr  Asp Leu Thr Ser Leu  Pro Leu Tyr Leu Pro  Gln Thr Leu 
    1895                 1900                 1905             


Val Ser  Leu Ser His Thr Ile  Glu Pro Val Met Lys  Thr Ser Val 
    1910                 1915                 1920             


Thr Thr  Ser Pro Gln Ser Asp  Met Met Arg Glu Gln  Leu Gln Leu 
    1925                 1930                 1935             


Ser Glu  Ala Thr Gly Thr Cys  Leu Gly Glu Arg Leu  Lys His Leu 
    1940                 1945                 1950             


Glu Arg  Leu Ile Arg Ser Ser  Arg Glu Glu Glu Val  Ala Ser Glu 
    1955                 1960                 1965             


Leu His  Leu Ser Ala Leu Leu  Asp Met Val Asp Ile  
    1970                 1975                 1980 


<210> 7004
<211> 170
<212> PRT
<213> Homo sapiens

<400> 7004
Met Gly Lys Arg Tyr Phe Cys Asp Tyr Cys Asp Arg Ser Phe Gln Asp 
1               5                   10                  15      


Asn Leu His Asn Arg Lys Lys His Leu Asn Gly Leu Gln His Leu Lys 
            20                  25                  30          


Ala Lys Lys Val Trp Tyr Asp Met Phe Arg Asp Ala Ala Ala Ile Leu 
        35                  40                  45              


Leu Asp Glu Gln Asn Lys Arg Pro Cys Arg Lys Phe Leu Leu Thr Gly 
    50                  55                  60                  


Gln Cys Asp Phe Gly Ser Asn Cys Arg Phe Ser His Met Ser Glu Arg 
65                  70                  75                  80  


Asp Leu Gln Glu Leu Ser Ile Gln Val Glu Glu Glu Arg Arg Ala Arg 
                85                  90                  95      


Glu Trp Leu Leu Asp Ala Pro Glu Leu Pro Glu Gly His Leu Glu Asp 
            100                 105                 110         


Trp Leu Glu Lys Arg Ala Lys Arg Leu Ser Ser Ala Pro Ser Ser Arg 
        115                 120                 125             


Ala Glu Pro Ile Arg Thr Thr Val Phe Gln Tyr Pro Val Gly Trp Pro 
    130                 135                 140                 


Pro Val Gln Glu Leu Pro Pro Ser Leu Arg Ala Pro Pro Pro Gly Gly 
145                 150                 155                 160 


Trp Pro Leu Gln Pro Arg Val Gln Trp Gly 
                165                 170 


<210> 7005
<211> 96
<212> PRT
<213> Homo sapiens

<400> 7005
Met Cys His Thr Ser Cys Ser Pro Ala Cys Gln Pro Thr Cys Cys Ile 
1               5                   10                  15      


His Ser Pro Cys Gln Ala Ser Cys Tyr Val Pro Val Ser Cys Gln Ser 
            20                  25                  30          


Ser Val Cys Met Pro Val Ser Cys Thr Arg Ile Val Cys Val Ala Pro 
        35                  40                  45              


Ser Cys Gln Pro Ser Val Cys Val Pro Val Ser Cys Arg Pro Ile Ile 
    50                  55                  60                  


Tyr Val Thr Pro Ser Cys Gln Ser Ser Gly Cys Cys Gln Pro Pro Cys 
65                  70                  75                  80  


Thr Thr Ala Leu Cys Arg Pro Ile Ser Cys Ser Thr Pro Ser Cys Cys 
                85                  90                  95      


<210> 7006
<211> 292
<212> PRT
<213> Homo sapiens

<400> 7006
Met Ala Ala Ser Thr Met Ser Ile Arg Ser Ser Ala Tyr Ser Asp Ser 
1               5                   10                  15      


Trp Gln Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Cys 
            20                  25                  30          


Ala Thr Ser Cys Cys Ala Pro Ala Pro Cys Leu Thr Leu Val Cys Thr 
        35                  40                  45              


Pro Val Ser Arg Val Ser Ser Pro Cys Cys Gln Val Thr Cys Glu Pro 
    50                  55                  60                  


Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys 
65                  70                  75                  80  


Gln Gln Ser Ser Cys Gln Pro Ala Tyr Cys Thr Ser Ser Pro Cys Gln 
                85                  90                  95      


Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Val Pro 
            100                 105                 110         


Val Cys Cys Gly Ala Ser Ser Cys Cys Gln Gln Ser Ser Tyr Gln Pro 
        115                 120                 125             


Ala Cys Cys Ala Ser Ser Ser Cys Gln Pro Ala Cys Cys Val Pro Val 
    130                 135                 140                 


Cys Cys Lys Pro Val Cys Cys Ala Pro Thr Cys Ser Glu Asp Ser Tyr 
145                 150                 155                 160 


Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser 
                165                 170                 175     


Pro Cys Gln Gln Ser Tyr Cys Val Pro Val Cys Cys Lys Pro Val Cys 
            180                 185                 190         


Cys Lys Pro Ile Cys Cys Val Pro Val Cys Ser Gly Ala Ser Ser Leu 
        195                 200                 205             


Cys Cys Gln Gln Ser Gly Cys Gln Pro Ala Cys Cys Thr Thr Ser Cys 
    210                 215                 220                 


Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Val Cys Arg 
225                 230                 235                 240 


Pro Ala Cys Cys Val Pro Val Ser Ser Cys Cys Ala Pro Thr Ser Ser 
                245                 250                 255     


Arg Gln Pro Ser Tyr Cys Arg Gln Ala Ser Cys Val Ser Leu Leu Cys 
            260                 265                 270         


Arg Pro Val Cys Ser Arg Pro Ala Cys Tyr Ser Phe Ser Ser Gly Gln 
        275                 280                 285             


Lys Ser Ser Cys 
    290         


<210> 7007
<211> 535
<212> PRT
<213> Homo sapiens

<400> 7007
Met Lys Lys Ile Ser Leu Lys Thr Leu Arg Lys Ser Phe Asn Leu Asn 
1               5                   10                  15      


Lys Ser Lys Glu Glu Thr Asp Phe Met Val Val Gln Gln Pro Ser Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Lys Asp Asp Ser Leu Phe Gly Ser Cys Tyr Gly 
        35                  40                  45              


Lys Asp Met Ala Ser Cys Asp Ile Asn Gly Glu Asp Glu Lys Gly Gly 
    50                  55                  60                  


Lys Asn Arg Ser Lys Ser Glu Ser Leu Met Gly Thr Leu Lys Arg Arg 
65                  70                  75                  80  


Leu Ser Ala Lys Gln Lys Ser Lys Gly Lys Ala Gly Thr Pro Ser Gly 
                85                  90                  95      


Ser Ser Ala Asp Glu Asp Thr Phe Ser Ser Ser Ser Ala Pro Ile Val 
            100                 105                 110         


Phe Lys Asp Val Arg Ala Gln Arg Pro Ile Arg Ser Thr Ser Leu Arg 
        115                 120                 125             


Ser His His Tyr Ser Pro Ala Pro Trp Pro Leu Arg Pro Thr Asn Ser 
    130                 135                 140                 


Glu Glu Thr Cys Ile Lys Met Glu Val Arg Val Lys Ala Leu Val His 
145                 150                 155                 160 


Ser Ser Ser Pro Ser Pro Ala Leu Asn Gly Val Arg Lys Asp Phe His 
                165                 170                 175     


Asp Leu Gln Ser Glu Thr Thr Cys Gln Glu Gln Ala Asn Ser Leu Lys 
            180                 185                 190         


Ser Ser Ala Ser His Asn Gly Asp Leu His Leu His Leu Asp Glu His 
        195                 200                 205             


Val Pro Val Val Ile Gly Leu Met Pro Gln Asp Tyr Ile Gln Tyr Thr 
    210                 215                 220                 


Val Pro Leu Asp Glu Gly Met Tyr Pro Leu Glu Gly Ser Arg Ser Tyr 
225                 230                 235                 240 


Cys Leu Asp Ser Ser Ser Pro Met Glu Val Ser Ala Val Pro Pro Gln 
                245                 250                 255     


Val Gly Gly Arg Ala Phe Pro Glu Asp Glu Ser Gln Val Asp Gln Asp 
            260                 265                 270         


Leu Val Val Ala Pro Glu Ile Phe Val Asp Gln Ser Val Asn Gly Leu 
        275                 280                 285             


Leu Ile Gly Thr Thr Gly Val Met Leu Gln Ser Pro Arg Ala Gly His 
    290                 295                 300                 


Asp Asp Val Pro Pro Leu Ser Pro Leu Leu Pro Pro Met Gln Asn Asn 
305                 310                 315                 320 


Gln Ile Gln Arg Asn Phe Ser Gly Leu Thr Gly Thr Glu Ala His Val 
                325                 330                 335     


Ala Glu Ser Met Arg Cys His Leu Asn Phe Asp Pro Asn Ser Ala Pro 
            340                 345                 350         


Gly Val Ala Arg Val Tyr Asp Ser Val Gln Ser Ser Gly Pro Met Val 
        355                 360                 365             


Val Thr Ser Leu Thr Glu Glu Leu Lys Lys Leu Ala Lys Gln Gly Trp 
    370                 375                 380                 


Tyr Trp Gly Pro Ile Thr Arg Trp Glu Ala Glu Gly Lys Leu Ala Asn 
385                 390                 395                 400 


Val Pro Asp Gly Ser Phe Leu Val Arg Asp Ser Ser Asp Asp Arg Tyr 
                405                 410                 415     


Leu Leu Ser Leu Ser Phe Arg Ser His Gly Lys Thr Leu His Thr Arg 
            420                 425                 430         


Ile Glu His Ser Asn Gly Arg Phe Ser Phe Tyr Glu Gln Pro Asp Val 
        435                 440                 445             


Glu Gly His Thr Ser Ile Val Asp Leu Ile Glu His Ser Ile Arg Asp 
    450                 455                 460                 


Ser Glu Asn Gly Ala Phe Cys Tyr Ser Arg Ser Arg Leu Pro Gly Ser 
465                 470                 475                 480 


Ala Thr Tyr Pro Val Arg Leu Thr Asn Pro Val Ser Arg Phe Met Gln 
                485                 490                 495     


Val Arg Ser Leu Gln Tyr Leu Cys Arg Phe Val Ile Arg Gln Tyr Thr 
            500                 505                 510         


Arg Ile Asp Leu Ile Gln Lys Leu Pro Leu Pro Asn Lys Met Lys Asp 
        515                 520                 525             


Tyr Leu Gln Glu Lys His Tyr 
    530                 535 


<210> 7008
<211> 419
<212> PRT
<213> Homo sapiens

<400> 7008
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys 
1               5                   10                  15      


Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu 
            20                  25                  30          


Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala 
        35                  40                  45              


Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His 
    50                  55                  60                  


Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr 
65                  70                  75                  80  


Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu 
                85                  90                  95      


Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg 
            100                 105                 110         


Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser 
        115                 120                 125             


Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His 
    130                 135                 140                 


Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn 
145                 150                 155                 160 


Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys 
                165                 170                 175     


Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val 
            180                 185                 190         


Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys 
        195                 200                 205             


Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val 
    210                 215                 220                 


Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile 
225                 230                 235                 240 


His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln 
                245                 250                 255     


Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys 
            260                 265                 270         


Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg 
        275                 280                 285             


Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp 
    290                 295                 300                 


Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe 
305                 310                 315                 320 


Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu 
                325                 330                 335     


Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp 
            340                 345                 350         


Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg 
        355                 360                 365             


Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu 
    370                 375                 380                 


Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys 
385                 390                 395                 400 


Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro 
                405                 410                 415     


Phe Phe Arg 
            


<210> 7009
<211> 320
<212> PRT
<213> Homo sapiens

<400> 7009
Met Ser Lys Ser Ala Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Thr Thr Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Lys Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Pro Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Arg Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Asp 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Cys Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Val Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210> 7010
<211> 578
<212> PRT
<213> Homo sapiens

<400> 7010
Met Glu Leu Glu Asn Ile Val Ala Asn Ser Leu Leu Leu Lys Ala Arg 
1               5                   10                  15      


Gln Gly Gly Tyr Gly Lys Lys Ser Gly Arg Ser Lys Lys Trp Lys Glu 
            20                  25                  30          


Ile Leu Thr Leu Pro Pro Val Ser Gln Cys Ser Glu Leu Arg His Ser 
        35                  40                  45              


Ile Glu Lys Asp Tyr Ser Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
    50                  55                  60                  


Arg Leu Phe Arg Gln Phe Cys Asp Thr Lys Pro Thr Leu Lys Arg His 
65                  70                  75                  80  


Ile Glu Phe Leu Asp Ala Val Ala Glu Tyr Glu Val Ala Asp Asp Glu 
                85                  90                  95      


Asp Arg Ser Asp Cys Gly Leu Ser Ile Leu Asp Arg Phe Phe Asn Asp 
            100                 105                 110         


Lys Leu Ala Ala Pro Leu Pro Glu Ile Pro Pro Asp Val Val Thr Glu 
        115                 120                 125             


Cys Arg Leu Gly Leu Lys Glu Glu Asn Pro Ser Lys Lys Ala Phe Glu 
    130                 135                 140                 


Glu Cys Thr Arg Val Ala His Asn Tyr Leu Arg Gly Glu Pro Phe Glu 
145                 150                 155                 160 


Glu Tyr Gln Glu Ser Ser Tyr Phe Ser Gln Phe Leu Gln Trp Lys Trp 
                165                 170                 175     


Leu Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg His Tyr Arg Val 
            180                 185                 190         


Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala 
        195                 200                 205             


Thr Gly Lys Met Tyr Ala Cys Lys Lys Leu Gln Lys Lys Arg Ile Lys 
    210                 215                 220                 


Lys Arg Lys Gly Glu Ala Met Ala Leu Asn Glu Lys Arg Ile Leu Glu 
225                 230                 235                 240 


Lys Val Gln Ser Arg Phe Val Val Ser Leu Ala Tyr Ala Tyr Glu Thr 
                245                 250                 255     


Lys Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu 
            260                 265                 270         


Lys Phe His Ile Tyr Asn Leu Gly Asn Pro Gly Phe Asp Glu Gln Arg 
        275                 280                 285             


Ala Val Phe Tyr Ala Ala Glu Leu Cys Cys Gly Leu Glu Asp Leu Gln 
    290                 295                 300                 


Arg Glu Arg Ile Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu 
305                 310                 315                 320 


Asp Asp Arg Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Thr Glu 
                325                 330                 335     


Ile Pro Glu Gly Gln Arg Val Arg Gly Arg Val Gly Thr Val Gly Tyr 
            340                 345                 350         


Met Ala Pro Glu Val Val Asn Asn Glu Lys Tyr Thr Phe Ser Pro Asp 
        355                 360                 365             


Trp Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Gln Gly His Ser 
    370                 375                 380                 


Pro Phe Lys Lys Tyr Lys Glu Lys Val Lys Trp Glu Glu Val Asp Gln 
385                 390                 395                 400 


Arg Ile Lys Asn Asp Thr Glu Glu Tyr Ser Glu Lys Phe Ser Glu Asp 
                405                 410                 415     


Ala Lys Ser Ile Cys Arg Met Leu Leu Thr Lys Asn Pro Ser Lys Arg 
            420                 425                 430         


Leu Gly Cys Arg Gly Glu Gly Ala Ala Gly Val Lys Gln His Pro Val 
        435                 440                 445             


Phe Lys Asp Ile Asn Phe Arg Arg Leu Glu Ala Asn Met Leu Glu Pro 
    450                 455                 460                 


Pro Phe Cys Pro Asp Pro His Ala Val Tyr Cys Lys Asp Val Leu Asp 
465                 470                 475                 480 


Ile Glu Gln Phe Ser Val Val Lys Gly Ile Tyr Leu Asp Thr Ala Asp 
                485                 490                 495     


Glu Asp Phe Tyr Ala Arg Phe Ala Thr Gly Cys Val Ser Ile Pro Trp 
            500                 505                 510         


Gln Asn Glu Met Ile Glu Ser Gly Cys Phe Lys Asp Ile Asn Lys Ser 
        515                 520                 525             


Glu Ser Glu Glu Ala Leu Pro Leu Asp Leu Asp Lys Asn Ile His Thr 
    530                 535                 540                 


Pro Val Ser Arg Pro Asn Arg Gly Phe Phe Tyr Arg Leu Phe Arg Arg 
545                 550                 555                 560 


Gly Gly Cys Leu Thr Met Val Pro Ser Glu Lys Glu Val Glu Pro Lys 
                565                 570                 575     


Gln Cys 
        


<210> 7011
<211> 874
<212> PRT
<213> Homo sapiens

<400> 7011
Met Asn Gln Arg Ser His Leu Gly Thr Thr Tyr Leu Asp Thr Ala Lys 
1               5                   10                  15      


Gly Ala Val Glu Thr Phe Met Lys Leu Arg Ala Arg Asp Pro Ala Ser 
            20                  25                  30          


Arg Gly Asp Arg Tyr Met Leu Val Thr Phe Glu Glu Pro Pro Tyr Ala 
        35                  40                  45              


Ile Lys Ala Gly Trp Lys Glu Asn His Ala Thr Phe Met Asn Glu Leu 
    50                  55                  60                  


Lys Asn Leu Gln Ala Glu Gly Leu Thr Thr Leu Gly Gln Ser Leu Arg 
65                  70                  75                  80  


Thr Ala Phe Asp Leu Leu Asn Leu Asn Arg Leu Val Thr Gly Ile Asp 
                85                  90                  95      


Asn Tyr Gly Gln Gly Arg Asn Pro Phe Phe Leu Glu Pro Ala Ile Ile 
            100                 105                 110         


Ile Thr Ile Thr Asp Gly Ser Lys Leu Thr Thr Thr Ser Gly Val Gln 
        115                 120                 125             


Asp Glu Leu His Leu Pro Leu Asn Ser Pro Leu Pro Gly Ser Glu Leu 
    130                 135                 140                 


Thr Lys Glu Pro Phe Arg Trp Asp Gln Arg Leu Phe Ala Leu Val Leu 
145                 150                 155                 160 


Arg Leu Pro Gly Thr Met Ser Val Glu Ser Glu Gln Leu Thr Gly Val 
                165                 170                 175     


Pro Leu Asp Asp Ser Ala Ile Thr Pro Met Cys Glu Val Thr Gly Gly 
            180                 185                 190         


Arg Ser Tyr Ser Val Cys Ser Pro Arg Met Leu Asn Gln Cys Leu Glu 
        195                 200                 205             


Ser Leu Val Gln Lys Val Gln Ser Gly Val Val Ile Asn Phe Glu Lys 
    210                 215                 220                 


Ala Gly Pro Asp Pro Ser Pro Val Glu Asp Gly Gln Pro Asp Ile Ser 
225                 230                 235                 240 


Arg Pro Phe Gly Ser Gln Pro Trp His Ser Cys His Lys Leu Ile Tyr 
                245                 250                 255     


Val Arg Pro Asn Pro Lys Thr Gly Val Pro Ile Gly His Trp Pro Val 
            260                 265                 270         


Pro Glu Ser Phe Trp Pro Asp Gln Asn Ser Pro Thr Leu Pro Pro Arg 
        275                 280                 285             


Thr Ser His Pro Val Val Lys Phe Ser Cys Thr Asp Cys Glu Pro Met 
    290                 295                 300                 


Val Ile Asp Lys Leu Pro Phe Asp Lys Tyr Glu Leu Glu Pro Ser Pro 
305                 310                 315                 320 


Leu Thr Gln Phe Ile Leu Glu Arg Lys Ser Pro Gln Thr Cys Trp Gln 
                325                 330                 335     


Val Tyr Val Ser Asn Ser Ala Lys Tyr Ser Glu Leu Gly His Pro Phe 
            340                 345                 350         


Gly Tyr Leu Lys Ala Ser Thr Ala Leu Asn Cys Val Asn Leu Phe Val 
        355                 360                 365             


Met Pro Tyr Asn Tyr Pro Val Leu Leu Pro Leu Leu Asp Asp Leu Phe 
    370                 375                 380                 


Lys Val His Lys Ala Lys Pro Thr Leu Lys Trp Arg Gln Ser Phe Glu 
385                 390                 395                 400 


Ser Tyr Leu Lys Thr Met Pro Pro Tyr Tyr Leu Gly Pro Leu Lys Lys 
                405                 410                 415     


Ala Val Arg Met Met Gly Ala Pro Asn Leu Ile Ala Asp Ser Met Glu 
            420                 425                 430         


Tyr Gly Leu Ser Tyr Ser Val Ile Ser Tyr Leu Lys Lys Leu Ser Gln 
        435                 440                 445             


Gln Ala Lys Ile Glu Ser Asp Arg Val Ile Gly Ser Val Gly Lys Lys 
    450                 455                 460                 


Val Val Gln Glu Thr Gly Ile Lys Val Arg Ser Arg Ser His Gly Leu 
465                 470                 475                 480 


Ser Met Ala Tyr Arg Lys Asp Phe Gln Gln Leu Leu Gln Gly Ile Ser 
                485                 490                 495     


Glu Asp Val Pro His Arg Leu Leu Asp Leu Asn Met Lys Glu Tyr Thr 
            500                 505                 510         


Gly Phe Gln Val Ala Leu Leu Asn Lys Asp Leu Lys Pro Gln Thr Phe 
        515                 520                 525             


Arg Asn Ala Tyr Asp Ile Pro Arg Arg Asn Leu Leu Asp His Leu Thr 
    530                 535                 540                 


Arg Met Arg Ser Asn Leu Leu Lys Ser Thr Arg Arg Phe Leu Lys Gly 
545                 550                 555                 560 


Gln Asp Glu Asp Gln Val His Ser Val Pro Ile Ala Gln Met Gly Asn 
                565                 570                 575     


Tyr Gln Glu Tyr Leu Lys Gln Val Pro Ser Pro Leu Arg Glu Leu Asp 
            580                 585                 590         


Pro Asp Gln Pro Arg Arg Leu His Thr Phe Gly Asn Pro Phe Lys Leu 
        595                 600                 605             


Asp Lys Lys Gly Met Met Ile Asp Glu Ala Asp Glu Phe Val Ala Gly 
    610                 615                 620                 


Pro Gln Asn Lys His Lys Arg Pro Gly Glu Pro Asn Met Gln Gly Ile 
625                 630                 635                 640 


Pro Lys Arg Arg Arg Cys Met Ser Pro Leu Leu Arg Gly Arg Gln Gln 
                645                 650                 655     


Asn Pro Val Val Asn Asn His Ile Gly Gly Lys Gly Pro Pro Ala Pro 
            660                 665                 670         


Thr Thr Gln Ala Gln Pro Asp Leu Ile Lys Pro Leu Pro Leu His Lys 
        675                 680                 685             


Ile Ser Glu Thr Thr Asn Asp Ser Ile Ile His Asp Val Val Glu Asn 
    690                 695                 700                 


His Val Ala Asp Gln Leu Ser Ser Asp Ile Thr Pro Asn Ala Met Asp 
705                 710                 715                 720 


Thr Glu Phe Ser Ala Ser Ser Pro Ala Ser Leu Leu Glu Arg Pro Thr 
                725                 730                 735     


Asn His Met Glu Ala Leu Gly His Asp His Leu Gly Thr Asn Asp Leu 
            740                 745                 750         


Thr Val Gly Gly Phe Leu Glu Asn His Glu Glu Pro Arg Asp Lys Glu 
        755                 760                 765             


Gln Cys Ala Glu Glu Asn Ile Pro Ala Ser Ser Leu Asn Lys Gly Lys 
    770                 775                 780                 


Lys Leu Met His Cys Arg Ser His Glu Glu Val Asn Thr Glu Leu Lys 
785                 790                 795                 800 


Ala Gln Ile Met Lys Glu Ile Arg Lys Pro Gly Arg Lys Tyr Glu Arg 
                805                 810                 815     


Ile Phe Thr Leu Leu Lys His Val Gln Gly Ser Leu Gln Thr Arg Leu 
            820                 825                 830         


Ile Phe Leu Gln Asn Val Ile Lys Glu Ala Ser Arg Phe Lys Lys Arg 
        835                 840                 845             


Met Leu Ile Glu Gln Leu Glu Asn Phe Leu Asp Glu Ile His Arg Arg 
    850                 855                 860                 


Ala Asn Gln Ile Asn His Ile Asn Ser Asn 
865                 870                 


<210> 7012
<211> 779
<212> PRT
<213> Homo sapiens

<400> 7012
Met Ala Asp Tyr Ser Asn Lys Leu Tyr Tyr Gln Leu Glu Gln Glu Thr 
1               5                   10                  15      


Gly Ile Gln Thr Gly Tyr Thr Arg Thr Gly Ser Ile Phe Leu Ala Gln 
            20                  25                  30          


Thr Gln Asp Arg Leu Ile Ser Leu Lys Arg Ile Asn Ala Gly Leu Asn 
        35                  40                  45              


Val Ile Gly Ile Pro Ser Glu Ile Ile Ser Pro Lys Lys Val Ala Glu 
    50                  55                  60                  


Leu His His Leu Leu Asn Val His Asp Leu Val Gly Ala Met His Val 
65                  70                  75                  80  


Pro Glu Asp Ala Val Val Ser Ser Ala Asp Val Ala Leu Ala Leu Ala 
                85                  90                  95      


Ser Ala Ala Ser Gln Asn Gly Val Gln Ile Tyr Asp Arg Thr Ser Val 
            100                 105                 110         


Leu His Val Met Val Lys Lys Gly Gln Val Thr Gly Val Glu Thr Asp 
        115                 120                 125             


Lys Gly Gln Ile Glu Cys Gln Tyr Phe Val Asn Cys Ala Gly Gln Trp 
    130                 135                 140                 


Ala Tyr Glu Leu Gly Leu Ser Asn Glu Glu Pro Val Ser Ile Pro Leu 
145                 150                 155                 160 


His Ala Cys Glu His Phe Tyr Leu Leu Thr Arg Pro Leu Glu Thr Pro 
                165                 170                 175     


Leu Gln Ser Ser Thr Pro Thr Ile Val Asp Ala Asp Gly Arg Ile Tyr 
            180                 185                 190         


Ile Arg Asn Trp Gln Gly Gly Ile Leu Ser Gly Gly Phe Glu Lys Asn 
        195                 200                 205             


Pro Lys Pro Ile Phe Thr Glu Gly Lys Asn Gln Leu Glu Ile Gln Asn 
    210                 215                 220                 


Leu Gln Glu Asp Trp Asp His Phe Glu Pro Leu Leu Ser Ser Leu Leu 
225                 230                 235                 240 


Arg Arg Met Pro Glu Leu Glu Thr Leu Glu Ile Met Lys Leu Val Asn 
                245                 250                 255     


Cys Pro Glu Thr Phe Thr Pro Asp Met Arg Cys Ile Met Gly Glu Ser 
            260                 265                 270         


Pro Ala Val Gln Gly Tyr Phe Val Leu Ala Gly Met Asn Ser Ala Gly 
        275                 280                 285             


Leu Ser Phe Gly Gly Gly Ala Gly Lys Tyr Leu Ala Glu Trp Met Val 
    290                 295                 300                 


His Gly Tyr Pro Ser Glu Asn Val Trp Glu Leu Asp Leu Lys Arg Phe 
305                 310                 315                 320 


Gly Ala Leu Gln Ser Ser Arg Thr Phe Leu Arg His Arg Val Met Glu 
                325                 330                 335     


Val Met Pro Leu Met Tyr Asp Leu Lys Val Pro Arg Trp Asp Phe Gln 
            340                 345                 350         


Thr Gly Arg Gln Leu Arg Thr Ser Pro Leu Tyr Asp Arg Leu Asp Ala 
        355                 360                 365             


Gln Gly Ala Arg Trp Met Glu Lys His Gly Phe Glu Arg Pro Lys Tyr 
    370                 375                 380                 


Phe Val Pro Pro Asp Lys Asp Leu Leu Ala Leu Glu Gln Ser Lys Thr 
385                 390                 395                 400 


Phe Tyr Lys Pro Asp Trp Phe Asp Ile Val Glu Ser Glu Val Lys Cys 
                405                 410                 415     


Cys Lys Glu Ala Val Cys Val Ile Asp Met Ser Ser Phe Thr Lys Phe 
            420                 425                 430         


Glu Ile Thr Ser Thr Gly Asp Gln Ala Leu Glu Val Leu Gln Tyr Leu 
        435                 440                 445             


Phe Ser Asn Asp Leu Asp Val Pro Val Gly His Ile Val His Thr Gly 
    450                 455                 460                 


Met Leu Asn Glu Gly Gly Gly Tyr Glu Asn Asp Cys Ser Ile Ala Arg 
465                 470                 475                 480 


Leu Asn Lys Arg Ser Phe Phe Met Ile Ser Pro Thr Asp Gln Gln Val 
                485                 490                 495     


His Cys Trp Ala Trp Leu Lys Lys His Met Pro Lys Asp Ser Asn Leu 
            500                 505                 510         


Leu Leu Glu Asp Val Thr Trp Lys Tyr Thr Ala Leu Asn Leu Ile Gly 
        515                 520                 525             


Pro Arg Ala Val Asp Val Leu Ser Glu Leu Ser Tyr Ala Pro Met Thr 
    530                 535                 540                 


Pro Asp His Phe Pro Ser Leu Phe Cys Lys Glu Met Ser Val Gly Tyr 
545                 550                 555                 560 


Ala Asn Gly Ile Arg Val Met Ser Met Thr His Thr Gly Glu Pro Gly 
                565                 570                 575     


Phe Met Leu Tyr Ile Pro Ile Glu Tyr Ala Leu His Val Tyr Asn Glu 
            580                 585                 590         


Val Met Ser Val Gly Gln Lys Tyr Gly Ile Arg Asn Ala Gly Tyr Tyr 
        595                 600                 605             


Ala Leu Arg Ser Leu Arg Ile Glu Lys Phe Phe Ala Phe Trp Gly Gln 
    610                 615                 620                 


Asp Ile Asn Asn Leu Thr Thr Pro Leu Glu Cys Gly Arg Glu Ser Arg 
625                 630                 635                 640 


Val Lys Leu Glu Lys Gly Met Asp Phe Ile Gly Arg Asp Ala Leu Leu 
                645                 650                 655     


Gln Gln Lys Gln Asn Gly Val Tyr Lys Arg Leu Thr Met Phe Ile Leu 
            660                 665                 670         


Asp Asp His Asp Ser Asp Leu Asp Leu Trp Pro Trp Trp Gly Glu Pro 
        675                 680                 685             


Ile Tyr Arg Asn Gly Gln Tyr Val Gly Lys Thr Thr Ser Ser Ala Tyr 
    690                 695                 700                 


Ser Tyr Ser Leu Glu Arg His Val Cys Leu Gly Phe Val His Asn Phe 
705                 710                 715                 720 


Ser Glu Asp Thr Gly Glu Glu Gln Val Val Thr Ala Asp Phe Ile Asn 
                725                 730                 735     


Arg Gly Glu Tyr Glu Ile Asp Ile Ala Gly Tyr Arg Phe Gln Ala Lys 
            740                 745                 750         


Ala Lys Leu Tyr Pro Val Ala Ser Leu Phe Thr Gln Lys Arg Arg Lys 
        755                 760                 765             


Asp Asp Met Glu Leu Ser Asp Leu His Gly Lys 
    770                 775                 


<210> 7013
<211> 396
<212> PRT
<213> Homo sapiens

<400> 7013
Met Ala Thr Arg Val Glu Glu Ala Ala Arg Gly Arg Gly Gly Gly Ala 
1               5                   10                  15      


Glu Glu Ala Thr Glu Ala Gly Arg Gly Gly Arg Arg Arg Ser Pro Arg 
            20                  25                  30          


Gln Lys Leu Glu Glu Ser Arg Ser Val Gln Lys Gln Met Lys Ile Leu 
        35                  40                  45              


Gln Lys Lys Gln Ala Gln Ile Val Lys Glu Lys Val His Leu Gln Ser 
    50                  55                  60                  


Glu His Ser Lys Ala Ile Leu Ala Arg Ser Lys Leu Glu Ser Leu Cys 
65                  70                  75                  80  


Arg Glu Leu Gln Arg His Asn Lys Thr Leu Lys Glu Glu Asn Met Gln 
                85                  90                  95      


Gln Ala Arg Glu Glu Glu Glu Arg Arg Lys Glu Ala Thr Ala His Phe 
            100                 105                 110         


Gln Ile Thr Leu Asn Glu Ile Gln Ala Gln Leu Glu Gln His Asp Ile 
        115                 120                 125             


His Asn Ala Lys Leu Arg Gln Glu Asn Ile Glu Leu Gly Glu Lys Leu 
    130                 135                 140                 


Lys Lys Leu Ile Glu Gln Tyr Ala Leu Arg Glu Glu His Ile Asp Lys 
145                 150                 155                 160 


Val Phe Lys His Lys Glu Leu Gln Gln Gln Leu Val Asp Ala Lys Leu 
                165                 170                 175     


Gln Gln Thr Thr Gln Leu Ile Lys Glu Ala Asp Glu Lys His Gln Arg 
            180                 185                 190         


Glu Arg Glu Phe Leu Leu Lys Glu Ala Thr Glu Ser Arg His Lys Tyr 
        195                 200                 205             


Glu Gln Met Lys Gln Gln Glu Val Gln Leu Lys Gln Gln Leu Ser Leu 
    210                 215                 220                 


Tyr Met Asp Lys Phe Glu Glu Phe Gln Thr Thr Met Ala Lys Ser Asn 
225                 230                 235                 240 


Glu Leu Phe Thr Thr Phe Arg Gln Glu Met Glu Lys Met Thr Lys Lys 
                245                 250                 255     


Ile Lys Lys Leu Glu Lys Glu Thr Ile Ile Trp Arg Thr Lys Trp Glu 
            260                 265                 270         


Asn Asn Asn Lys Ala Leu Leu Gln Met Ala Glu Glu Lys Thr Val Arg 
        275                 280                 285             


Asp Lys Glu Tyr Lys Ala Leu Gln Ile Lys Leu Glu Arg Leu Glu Lys 
    290                 295                 300                 


Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Glu Leu Asn Glu Lys Val 
305                 310                 315                 320 


Glu Val Leu Lys Glu Gln Val Ser Ile Lys Ala Ala Ile Lys Ala Ala 
                325                 330                 335     


Asn Arg Asp Leu Ala Thr Pro Val Met Gln Pro Cys Thr Ala Leu Asp 
            340                 345                 350         


Ser His Lys Glu Leu Asn Thr Ser Ser Lys Arg Ala Leu Gly Ala His 
        355                 360                 365             


Leu Glu Ala Glu Pro Lys Ser Gln Arg Ser Ala Val Gln Lys Pro Pro 
    370                 375                 380                 


Ser Thr Gly Ser Ala Pro Ala Ile Glu Ser Val Asp 
385                 390                 395     


<210> 7014
<211> 480
<212> PRT
<213> Homo sapiens

<400> 7014
Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ala Glu Met 
                85                  90                  95      


Glu Leu Val Gln His Ile Gly Ile Pro Ala Ser Lys Ile Ile Cys Ala 
            100                 105                 110         


Asn Pro Cys Lys Gln Ile Ala Gln Ile Lys Tyr Ala Ala Lys His Gly 
        115                 120                 125             


Ile Gln Leu Leu Ser Phe Asp Asn Glu Met Glu Leu Ala Lys Val Val 
    130                 135                 140                 


Lys Ser His Pro Ser Ala Lys Met Val Leu Cys Ile Ala Thr Asp Asp 
145                 150                 155                 160 


Ser His Ser Leu Ser Cys Leu Ser Leu Lys Phe Gly Val Ser Leu Lys 
                165                 170                 175     


Ser Cys Arg His Leu Leu Glu Asn Ala Lys Lys His His Val Glu Val 
            180                 185                 190         


Val Gly Val Ser Phe His Ile Gly Ser Gly Cys Pro Asp Pro Gln Ala 
        195                 200                 205             


Tyr Ala Gln Ser Ile Ala Asp Ala Arg Leu Val Phe Glu Met Gly Thr 
    210                 215                 220                 


Glu Leu Gly His Lys Met His Val Leu Asp Leu Gly Gly Gly Phe Pro 
225                 230                 235                 240 


Gly Thr Glu Gly Ala Lys Val Arg Phe Glu Glu Ile Ala Ser Val Ile 
                245                 250                 255     


Asn Ser Ala Leu Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val Asp Ile 
            260                 265                 270         


Phe Ala Glu Leu Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr Val Ala 
        275                 280                 285             


Val Ser Ile Ile Ala Lys Lys Glu Val Leu Leu Asp Gln Pro Gly Arg 
    290                 295                 300                 


Glu Ala Pro Leu Pro Pro Pro His Ile Ala Thr Cys Ala Ala Ser Glu 
305                 310                 315                 320 


Pro Ser Pro Pro Ala Glu Glu Asn Gly Ser Thr Ser Lys Thr Ile Val 
                325                 330                 335     


Tyr His Leu Asp Glu Gly Val Tyr Gly Ile Phe Asn Ser Val Leu Phe 
            340                 345                 350         


Asp Asn Ile Cys Pro Thr Pro Ile Leu Gln Lys Lys Pro Ser Thr Glu 
        355                 360                 365             


Gln Pro Leu Tyr Ser Ser Ser Leu Trp Gly Pro Ala Val Asp Gly Cys 
    370                 375                 380                 


Asp Cys Val Ala Glu Gly Leu Trp Leu Pro Gln Leu His Val Gly Asp 
385                 390                 395                 400 


Trp Leu Val Phe Asp Asn Met Gly Ala Tyr Thr Val Gly Met Gly Ser 
                405                 410                 415     


Pro Phe Trp Gly Thr Gln Ala Cys His Ile Thr Tyr Ala Met Ser Arg 
            420                 425                 430         


Val Ala Trp Glu Ala Leu Arg Arg Gln Leu Met Ala Ala Glu Gln Glu 
        435                 440                 445             


Asp Asp Val Glu Gly Val Cys Lys Pro Leu Ser Cys Gly Trp Glu Ile 
    450                 455                 460                 


Thr Asp Thr Leu Cys Val Gly Pro Val Phe Thr Pro Ala Ser Ile Met 
465                 470                 475                 480 


<210> 7015
<211> 1257
<212> PRT
<213> Homo sapiens

<400> 7015
Met Ala His Phe Ser Ser Glu Asp Gln Ala Met Leu Gln Ala Met Leu 
1               5                   10                  15      


Arg Arg Leu Phe Gln Ser Val Lys Glu Lys Ile Thr Gly Ala Pro Ser 
            20                  25                  30          


Leu Glu Cys Ala Glu Glu Ile Leu Leu His Leu Glu Glu Thr Asp Glu 
        35                  40                  45              


Asn Phe His Asn Tyr Glu Phe Val Lys Tyr Leu Arg Gln His Ile Gly 
    50                  55                  60                  


Asn Thr Leu Gly Ser Met Ile Glu Glu Glu Met Glu Lys Cys Thr Ser 
65                  70                  75                  80  


Asp Arg Asn Gln Gly Glu Glu Cys Gly Tyr Asp Thr Val Val Gln Gln 
                85                  90                  95      


Val Thr Lys Arg Thr Gln Glu Ser Lys Glu Tyr Lys Glu Met Met His 
            100                 105                 110         


Tyr Leu Lys Asn Ile Met Ile Ala Val Val Glu Ser Met Ile Asn Lys 
        115                 120                 125             


Phe Glu Glu Asp Glu Thr Arg Asn Gln Glu Arg Gln Lys Lys Ile Gln 
    130                 135                 140                 


Lys Glu Lys Ser His Ser Tyr Arg Thr Asp Asn Cys Ser Asp Ser Asp 
145                 150                 155                 160 


Ser Ser Leu Asn Gln Ser Tyr Lys Phe Cys Gln Gly Lys Leu Gln Leu 
                165                 170                 175     


Ile Leu Asp Gln Leu Asp Pro Gly Gln Pro Lys Glu Val Arg Tyr Glu 
            180                 185                 190         


Ala Leu Gln Thr Leu Cys Ser Ala Pro Pro Ser Asp Val Leu Asn Cys 
        195                 200                 205             


Glu Asn Trp Thr Thr Leu Cys Glu Lys Leu Thr Val Ser Leu Ser Asp 
    210                 215                 220                 


Pro Asp Pro Val Phe Ser Asp Arg Ile Leu Lys Phe Cys Ala Gln Thr 
225                 230                 235                 240 


Phe Leu Leu Ser Pro Leu His Met Thr Lys Glu Ile Tyr Thr Ser Leu 
                245                 250                 255     


Ala Lys Tyr Leu Glu Ser Tyr Phe Leu Ser Arg Glu Asn His Ile Pro 
            260                 265                 270         


Thr Leu Ser Ala Gly Val Asp Ile Thr Asn Pro Asn Met Thr Arg Leu 
        275                 280                 285             


Leu Lys Lys Val Arg Leu Leu Asn Glu Tyr Gln Lys Glu Ala Pro Ser 
    290                 295                 300                 


Phe Trp Ile Arg His Pro Glu Lys Tyr Met Glu Glu Ile Val Glu Ser 
305                 310                 315                 320 


Thr Leu Ser Leu Leu Thr Val Lys His Asn Gln Ser His Val Val Ser 
                325                 330                 335     


Gln Lys Ile Leu Asp Pro Ile Tyr Phe Phe Ala Leu Val Asp Thr Lys 
            340                 345                 350         


Ala Val Trp Phe Lys Lys Trp Met His Ala His Tyr Ser Arg Thr Thr 
        355                 360                 365             


Val Leu Arg Leu Leu Glu Thr Lys Tyr Lys Ser Leu Val Thr Thr Ala 
    370                 375                 380                 


Ile Gln Gln Cys Val Gln Tyr Phe Glu Met Cys Lys Thr Arg Lys Ala 
385                 390                 395                 400 


Asp Glu Thr Leu Gly His Ser Lys His Cys Arg Asn Lys Gln Lys Thr 
                405                 410                 415     


Phe Tyr Tyr Leu Gly Gln Glu Leu Gln Tyr Ile Tyr Phe Ile His Ser 
            420                 425                 430         


Leu Cys Leu Leu Gly Arg Leu Leu Ile Tyr Lys Gln Gly Arg Lys Leu 
        435                 440                 445             


Phe Pro Ile Lys Leu Lys Asn Lys Lys Gly Leu Val Ser Leu Ile Asp 
    450                 455                 460                 


Leu Leu Val Leu Phe Thr Gln Leu Ile Tyr Tyr Ser Pro Ser Cys Pro 
465                 470                 475                 480 


Lys Met Thr Ser Ala Ala His Ser Glu Asn Tyr Ser Pro Ala Ser Met 
                485                 490                 495     


Val Thr Glu Val Leu Trp Ile Leu Ser Asp Gln Lys Glu Cys Ala Val 
            500                 505                 510         


Glu Cys Leu Tyr Asn Asn Ile Val Ile Glu Thr Leu Leu Gln Pro Ile 
        515                 520                 525             


His Asn Leu Met Lys Gly Asn Glu Ala Ser Pro Asn Cys Ser Glu Thr 
    530                 535                 540                 


Ala Leu Ile His Ile Ala Gly Ile Leu Ala Arg Ile Ala Ser Val Glu 
545                 550                 555                 560 


Glu Gly Leu Ile Leu Leu Leu Tyr Gly Ala Asn Met Asn Ser Ser Glu 
                565                 570                 575     


Glu Ser Pro Thr Gly Ala His Ile Ile Ala Gln Phe Ser Lys Lys Leu 
            580                 585                 590         


Leu Asp Glu Asp Ile Ser Ile Phe Ser Gly Ser Glu Met Leu Pro Val 
        595                 600                 605             


Val Lys Gly Ala Phe Ile Ser Val Cys Arg His Ile Tyr Ser Thr Cys 
    610                 615                 620                 


Glu Gly Leu Gln Val Leu Ile Thr Tyr Asn Leu His Glu Ser Ile Ala 
625                 630                 635                 640 


Lys Ala Trp Lys Lys Thr Ser Leu Leu Ser Glu Arg Ile Pro Thr Pro 
                645                 650                 655     


Val Glu Gly Ser Asp Ser Val Ser Ser Val Ser Gln Glu Ser Gln Asn 
            660                 665                 670         


Ile Met Ala Trp Glu Asp Asn Leu Leu Asp Asp Leu Leu His Phe Ala 
        675                 680                 685             


Ala Thr Pro Lys Gly Leu Leu Leu Leu Gln Arg Thr Gly Ala Ile Asn 
    690                 695                 700                 


Glu Cys Val Thr Phe Ile Phe Asn Arg Tyr Ala Lys Lys Leu Gln Val 
705                 710                 715                 720 


Ser Arg His Lys Lys Phe Gly Tyr Gly Val Leu Val Thr Arg Val Ala 
                725                 730                 735     


Ser Thr Ala Ala Gly Gly Ile Ala Leu Lys Lys Ser Gly Phe Ile Asn 
            740                 745                 750         


Glu Leu Ile Thr Glu Leu Trp Ser Asn Leu Glu Tyr Gly Arg Asp Asp 
        755                 760                 765             


Val Arg Val Thr His Pro Arg Thr Thr Pro Val Asp Pro Ile Asp Arg 
    770                 775                 780                 


Ser Cys Gln Lys Ser Phe Leu Ala Leu Val Asn Leu Leu Ser Tyr Pro 
785                 790                 795                 800 


Ala Ile Tyr Glu Leu Val Arg Asn Gln Asp Leu Pro Asn Lys Thr Glu 
                805                 810                 815     


Tyr Ser Leu Arg Glu Val Pro Thr Cys Val Ile Asp Ile Ile Asp Arg 
            820                 825                 830         


Leu Ile Ile Leu Asn Ser Glu Ala Lys Ile Arg Ser Leu Phe Asn Tyr 
        835                 840                 845             


Glu Gln Ser His Ile Phe Gly Leu Arg Asp Phe Ile Ile Asp Gly Leu 
    850                 855                 860                 


Ser Val Glu Arg Asn His Val Leu Val Arg Ile Asn Leu Val Gly Gly 
865                 870                 875                 880 


Pro Leu Glu Arg Ile Leu Pro Pro Arg Leu Leu Glu Lys Ser Asp Asn 
                885                 890                 895     


Pro Tyr Pro Trp Pro Met Phe Ser Ser Tyr Pro Leu Pro Asn Cys Tyr 
            900                 905                 910         


Leu Ser Asp Ile Thr Arg Asn Ala Gly Ile Lys Gln Asp Asn Asp Leu 
        915                 920                 925             


Asp Lys Leu Leu Leu Cys Leu Lys Ile Ser Asp Lys Gln Thr Glu Trp 
    930                 935                 940                 


Ile Glu Asn Cys Gln Arg Gln Phe Cys Lys Met Met Lys Ala Lys Pro 
945                 950                 955                 960 


Asp Ile Ile Ser Gly Glu Ala Leu Ile Glu Leu Leu Glu Lys Phe Val 
                965                 970                 975     


Leu His Leu Thr Glu Ser Pro Ser Glu Cys Tyr Phe Pro Ser Val Glu 
            980                 985                 990         


Tyr Thr Ala Thr Asp Ala Asn Val  Lys Asn Glu Ser Leu  Ser Ser Val 
        995                 1000                 1005             


Gln Gln  Leu Gly Ile Lys Met  Thr Val Arg Tyr Gly  Lys Phe Leu 
    1010                 1015                 1020             


Ser Leu  Leu Lys Asp Gly Ala  Glu Asn Asp Leu Thr  Trp Val Leu 
    1025                 1030                 1035             


Lys His  Cys Glu Arg Phe Leu  Lys Gln Gln Gln Thr  Ser Ile Lys 
    1040                 1045                 1050             


Ser Ser  Leu Leu Cys Leu Gln  Gly Asn Tyr Ala Gly  His Asp Trp 
    1055                 1060                 1065             


Phe Val  Ser Ser Leu Phe Met  Ile Met Leu Gly Asp  Lys Glu Lys 
    1070                 1075                 1080             


Thr Phe  Gln Phe Leu His Gln  Phe Ser Arg Leu Leu  Thr Ser Ala 
    1085                 1090                 1095             


Phe Leu  Trp Leu Pro Arg Leu  His Ile Ser Ser Tyr  Leu Pro Asn 
    1100                 1105                 1110             


Asp Thr  Val Glu Ser Gly Ile  His Pro Val Tyr Phe  Cys Ser Thr 
    1115                 1120                 1125             


His Tyr  Ile Glu Met Leu Leu  Lys Ala Glu Leu Pro  Leu Val Phe 
    1130                 1135                 1140             


Ser Ala  Phe His Met Ser Gly  Phe Ala Pro Ser Gln  Ile Cys Leu 
    1145                 1150                 1155             


Gln Trp  Ile Thr Gln Cys Phe  Trp Asn Tyr Leu Asp  Trp Ile Glu 
    1160                 1165                 1170             


Ile Cys  His Tyr Ile Ala Thr  Cys Val Phe Leu Gly  Pro Asp Tyr 
    1175                 1180                 1185             


Gln Val  Tyr Ile Cys Ile Ala  Val Phe Lys His Leu  Gln Gln Asp 
    1190                 1195                 1200             


Ile Leu  Gln His Thr Gln Thr  Gln Asp Leu Gln Val  Phe Leu Lys 
    1205                 1210                 1215             


Glu Glu  Ala Leu His Gly Phe  Arg Val Ser Asp Tyr  Phe Glu Tyr 
    1220                 1225                 1230             


Met Glu  Ile Leu Glu Gln Asn  Tyr Arg Thr Val Leu  Leu Arg Asp 
    1235                 1240                 1245             


Met Arg  Asn Ile Arg Leu Gln  Ser Thr 
    1250                 1255         


<210> 7016
<211> 203
<212> PRT
<213> Homo sapiens

<400> 7016
Met Ala Thr Pro Tyr Val Thr Asp Glu Thr Gly Gly Lys Tyr Ile Ala 
1               5                   10                  15      


Ser Thr Gln Arg Pro Asp Gly Thr Trp Arg Lys Gln Arg Arg Val Lys 
            20                  25                  30          


Glu Gly Tyr Val Pro Gln Glu Glu Val Pro Val Tyr Glu Asn Lys Tyr 
        35                  40                  45              


Val Lys Phe Phe Lys Ser Lys Pro Glu Leu Pro Pro Gly Leu Ser Pro 
    50                  55                  60                  


Glu Ala Thr Ala Pro Val Thr Pro Ser Arg Pro Glu Gly Gly Glu Pro 
65                  70                  75                  80  


Gly Leu Ser Lys Thr Ala Lys Arg Asn Leu Lys Arg Lys Glu Lys Arg 
                85                  90                  95      


Arg Gln Gln Gln Glu Lys Gly Glu Ala Glu Ala Leu Ser Arg Thr Leu 
            100                 105                 110         


Asp Lys Val Ser Leu Glu Glu Thr Ala Gln Leu Pro Ser Ala Pro Gln 
        115                 120                 125             


Gly Ser Arg Ala Ala Pro Thr Ala Ala Ser Asp Gln Pro Asp Ser Ala 
    130                 135                 140                 


Ala Thr Thr Glu Lys Ala Lys Lys Ile Lys Asn Leu Lys Lys Lys Leu 
145                 150                 155                 160 


Arg Gln Val Glu Glu Leu Gln Gln Arg Ile Gln Ala Gly Glu Val Ser 
                165                 170                 175     


Gln Pro Ser Lys Glu Gln Leu Glu Lys Leu Ala Arg Arg Arg Ala Leu 
            180                 185                 190         


Glu Glu Glu Leu Glu Asp Leu Glu Leu Gly Leu 
        195                 200             


<210> 7017
<211> 242
<212> PRT
<213> Homo sapiens

<400> 7017
Met Ala Ala Val Lys Ala Ser Thr Ser Lys Ala Thr Arg Pro Trp Tyr 
1               5                   10                  15      


Ser His Pro Val Tyr Ala Arg Tyr Trp Gln His Tyr His Gln Ala Met 
            20                  25                  30          


Ala Trp Met Gln Ser His His Asn Ala Tyr Arg Lys Ala Val Glu Ser 
        35                  40                  45              


Cys Phe Asn Leu Pro Trp Tyr Leu Pro Ser Ala Leu Leu Pro Gln Ser 
    50                  55                  60                  


Ser Tyr Asp Asn Glu Ala Ala Tyr Pro Gln Ser Phe Tyr Asp His His 
65                  70                  75                  80  


Val Ala Trp Gln Asp Tyr Pro Cys Ser Ser Ser His Phe Arg Arg Ser 
                85                  90                  95      


Gly Gln His Pro Arg Tyr Ser Ser Arg Ile Gln Ala Ser Thr Lys Glu 
            100                 105                 110         


Asp Gln Ala Leu Ser Lys Glu Glu Glu Met Glu Thr Glu Ser Asp Ala 
        115                 120                 125             


Glu Val Glu Cys Asp Leu Ser Asn Met Glu Ile Thr Glu Glu Leu Arg 
    130                 135                 140                 


Gln Tyr Phe Ala Glu Thr Glu Arg His Arg Glu Glu Arg Arg Arg Gln 
145                 150                 155                 160 


Gln Gln Leu Asp Ala Glu Arg Leu Asp Ser Tyr Val Asn Ala Asp His 
                165                 170                 175     


Asp Leu Tyr Cys Asn Thr Arg Arg Ser Val Glu Ala Pro Thr Glu Arg 
            180                 185                 190         


Pro Gly Glu Arg Arg Gln Ala Glu Met Lys Arg Leu Tyr Gly Asp Ser 
        195                 200                 205             


Ala Ala Lys Ile Gln Ala Met Glu Ala Ala Val Gln Leu Ser Phe Asp 
    210                 215                 220                 


Lys His Cys Asp Arg Lys Gln Pro Lys Tyr Trp Pro Val Ile Pro Leu 
225                 230                 235                 240 


Lys Phe 
        


<210> 7018
<211> 245
<212> PRT
<213> Homo sapiens

<400> 7018
Met Ile Gly Val Ser Phe Glu Glu Ala Lys Ser Ile Ile Thr Gly Ala 
1               5                   10                  15      


Lys Leu Ser Thr Arg Leu Glu Ser Ala Trp Glu Ile Ala Phe Ile Arg 
            20                  25                  30          


Gln Lys Ser Asp Asn Ile Gln Pro Glu Asn Leu Ser Cys Thr Ser Leu 
        35                  40                  45              


Ile Glu Ala Ser Gly Glu Tyr Gly Pro Gln Ala Ser Thr Leu Ser Leu 
    50                  55                  60                  


Phe Ser Ser Pro Pro Glu Ile Leu Ile Pro Lys Thr Ser Ser Thr Pro 
65                  70                  75                  80  


Lys Thr Asn Asn Asp Ile Leu Ser Ser Cys Glu Ile Lys Thr Gly Tyr 
                85                  90                  95      


Asn Lys Thr Val Gln Ile Pro Ile Thr Ser Glu Asn Ser Thr Val Gly 
            100                 105                 110         


Leu Ser Asn Thr Asp Val Ala Ser Ala Trp Thr Glu Asn Tyr Gly Leu 
        115                 120                 125             


Gln Glu Lys Ile Ser Leu Asn Pro Ser Val Arg Phe Lys Ala Glu Lys 
    130                 135                 140                 


Leu Glu Met Ala Leu Asn Tyr Leu Gly Ile Gln Pro Thr Lys Glu Gln 
145                 150                 155                 160 


His Gln Ala Leu Arg Gln Gln Val Gln Ala Asp Ser Lys Gly Thr Val 
                165                 170                 175     


Ser Phe Gly Asp Phe Val Gln Val Ala Arg Asn Leu Phe Cys Leu Gln 
            180                 185                 190         


Leu Asp Glu Val Asn Val Gly Ala His Glu Ile Ser Asn Ile Leu Asp 
        195                 200                 205             


Ser Gln Leu Leu Pro Cys Asp Ser Ser Glu Ala Asp Glu Met Glu Arg 
    210                 215                 220                 


Leu Lys Cys Glu Arg Asp Asp Ala Leu Lys Glu Val Asn Thr Leu Lys 
225                 230                 235                 240 


Trp Pro Gly Gln Asn 
                245 


<210> 7019
<211> 339
<212> PRT
<213> Homo sapiens

<400> 7019
Met Met Asp Ser Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe 
1               5                   10                  15      


Ser Tyr Ala Gly Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys 
            20                  25                  30          


Ile Ala Leu Leu Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn 
        35                  40                  45              


Ala Glu Ile Arg Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp 
    50                  55                  60                  


Ala Glu Trp Asn Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser 
65                  70                  75                  80  


Gly Ala Lys Val Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr 
                85                  90                  95      


Gln Tyr Phe Ala Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu 
            100                 105                 110         


Glu Asp Leu Lys Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr 
        115                 120                 125             


Ser Val Asn Ala Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe 
    130                 135                 140                 


Glu Glu Thr Gln Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys 
145                 150                 155                 160 


Pro Lys Ala Lys Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln 
                165                 170                 175     


Phe Met Glu Glu Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val 
            180                 185                 190         


Arg Arg Ala Ile Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile 
        195                 200                 205             


Glu Met Glu Leu Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro 
    210                 215                 220                 


Gly Lys Gln Gln Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile 
225                 230                 235                 240 


Ile Pro Arg Gln Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile 
                245                 250                 255     


Leu Asn Lys Leu Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly 
            260                 265                 270         


Val Asp Ile Asn Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val 
        275                 280                 285             


Trp Glu Pro Ala Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu 
    290                 295                 300                 


Ala Ala Cys Leu Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg 
305                 310                 315                 320 


Ser Thr Val Asp Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly 
                325                 330                 335     


Arg Pro His 
            


<210> 7020
<211> 255
<212> PRT
<213> Homo sapiens

<400> 7020
Met Ala Ser Ser Asp Leu Glu Gln Leu Cys Ser His Val Asn Glu Lys 
1               5                   10                  15      


Ile Gly Asn Ile Lys Lys Thr Leu Ser Leu Arg Asn Cys Gly Gln Glu 
            20                  25                  30          


Pro Thr Leu Lys Thr Val Leu Asn Lys Ile Gly Asp Glu Ile Ile Val 
        35                  40                  45              


Ile Asn Glu Leu Leu Asn Lys Leu Glu Leu Glu Ile Gln Tyr Gln Glu 
    50                  55                  60                  


Gln Thr Asn Asn Ser Leu Lys Glu Leu Cys Glu Ser Leu Glu Glu Asp 
65                  70                  75                  80  


Tyr Lys Asp Ile Glu His Leu Lys Glu Asn Val Pro Ser His Leu Pro 
                85                  90                  95      


Gln Val Thr Val Thr Gln Ser Cys Val Lys Gly Ser Asp Leu Asp Pro 
            100                 105                 110         


Glu Glu Pro Ile Lys Val Glu Glu Pro Glu Pro Val Lys Lys Pro Pro 
        115                 120                 125             


Lys Glu Gln Arg Ser Ile Lys Glu Met Pro Phe Ile Thr Cys Asp Glu 
    130                 135                 140                 


Phe Asn Gly Val Pro Ser Tyr Met Lys Ser Arg Leu Thr Tyr Asn Gln 
145                 150                 155                 160 


Ile Asn Asp Val Ile Lys Glu Ile Asn Lys Ala Val Ile Ser Lys Tyr 
                165                 170                 175     


Lys Ile Leu His Gln Pro Lys Lys Ser Met Asn Ser Val Thr Arg Asn 
            180                 185                 190         


Leu Tyr His Arg Phe Ile Asp Glu Glu Thr Lys Asp Thr Lys Gly Arg 
        195                 200                 205             


Tyr Phe Ile Val Glu Ala Asp Ile Lys Glu Phe Thr Thr Leu Lys Ala 
    210                 215                 220                 


Asp Lys Lys Phe His Val Leu Leu Asn Ile Leu Arg His Cys Arg Arg 
225                 230                 235                 240 


Leu Ser Glu Val Arg Gly Gly Gly Leu Thr Arg Tyr Val Ile Thr 
                245                 250                 255 


<210> 7021
<211> 146
<212> PRT
<213> Homo sapiens

<400> 7021
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Asp 
1               5                   10                  15      


Gln Gly Leu Cys Gln Glu Thr Cys Cys Arg Pro Ser Cys Cys Gln Thr 
            20                  25                  30          


Thr Cys Cys Cys Pro Ser Cys Val Val Ser Ser Cys Cys Arg Pro Ser 
        35                  40                  45              


Cys Ser Gln Thr Thr Cys Cys Gln Thr Thr Cys Cys Arg Pro Ser Cys 
    50                  55                  60                  


Cys His Pro Val Cys Cys Gln Thr Thr Cys Arg Pro Ser Cys Gly Val 
65                  70                  75                  80  


Ser Ser Cys Cys Arg Pro Leu Cys Cys Gln Thr Thr Cys His Pro Ser 
                85                  90                  95      


Cys Gly Met Ser Ser Cys Cys Arg Pro Leu Cys Cys Gln Thr Thr Cys 
            100                 105                 110         


Arg Pro Ser Cys Gly Val Ser Ser Cys Cys Arg Pro Leu Cys Cys Gln 
        115                 120                 125             


Thr Thr Cys Cys Arg Ala Thr Cys Cys Arg Pro Ser Cys Cys Gly Ser 
    130                 135                 140                 


Ser Cys 
145     


<210> 7022
<211> 431
<212> PRT
<213> Homo sapiens

<400> 7022
Met Thr Ser Asp Cys Ser Ser Thr His Cys Ser Pro Glu Ser Cys Gly 
1               5                   10                  15      


Thr Ala Ser Gly Cys Ala Pro Ala Ser Ser Cys Ser Val Glu Thr Ala 
            20                  25                  30          


Cys Leu Pro Gly Thr Cys Ala Thr Ser Arg Cys Gln Thr Pro Ser Phe 
        35                  40                  45              


Leu Ser Arg Ser Arg Gly Leu Thr Gly Cys Leu Leu Pro Cys Tyr Phe 
    50                  55                  60                  


Thr Gly Ser Cys Asn Ser Pro Cys Leu Val Gly Asn Cys Ala Trp Cys 
65                  70                  75                  80  


Glu Asp Gly Val Phe Thr Ser Asn Glu Lys Glu Thr Met Gln Phe Leu 
                85                  90                  95      


Asn Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg Ser Leu Glu Glu 
            100                 105                 110         


Thr Asn Ala Glu Leu Glu Ser Arg Ile Gln Glu Gln Cys Glu Gln Asp 
        115                 120                 125             


Ile Pro Met Val Cys Pro Asp Tyr Gln Arg Tyr Phe Asn Thr Ile Glu 
    130                 135                 140                 


Asp Leu Gln Gln Lys Ile Leu Cys Thr Lys Ala Glu Asn Ser Arg Leu 
145                 150                 155                 160 


Ala Val Gln Leu Asp Asn Cys Lys Leu Ala Thr Asp Asp Phe Lys Ser 
                165                 170                 175     


Lys Tyr Glu Ser Glu Leu Ser Leu Arg Gln Leu Leu Glu Ala Asp Ile 
            180                 185                 190         


Ser Ser Leu His Gly Ile Leu Glu Glu Leu Thr Leu Cys Lys Ser Asp 
        195                 200                 205             


Leu Glu Ala His Val Glu Ser Leu Lys Glu Asp Leu Leu Cys Leu Lys 
    210                 215                 220                 


Lys Asn His Glu Glu Glu Val Asn Leu Leu Arg Glu Gln Leu Gly Asp 
225                 230                 235                 240 


Arg Leu Ser Val Glu Leu Asp Thr Ala Pro Thr Leu Asp Leu Asn Arg 
                245                 250                 255     


Val Leu Asp Glu Met Arg Cys Gln Cys Glu Thr Val Leu Ala Asn Asn 
            260                 265                 270         


Arg Arg Glu Ala Glu Glu Trp Leu Ala Val Gln Thr Glu Glu Leu Asn 
        275                 280                 285             


Gln Gln Gln Leu Ser Ser Ala Glu Gln Leu Gln Gly Cys Gln Met Glu 
    290                 295                 300                 


Ile Leu Glu Leu Lys Arg Thr Ala Ser Ala Leu Glu Ile Glu Leu Gln 
305                 310                 315                 320 


Ala Gln Gln Ser Leu Thr Glu Ser Leu Glu Cys Thr Val Ala Glu Thr 
                325                 330                 335     


Glu Ala Gln Tyr Ser Ser Gln Leu Ala Gln Ile Gln Cys Leu Ile Asp 
            340                 345                 350         


Asn Leu Glu Asn Gln Leu Ala Glu Ile Arg Cys Asp Leu Glu Arg Gln 
        355                 360                 365             


Asn Gln Glu Tyr Gln Val Leu Leu Asp Val Lys Ala Arg Leu Glu Gly 
    370                 375                 380                 


Glu Ile Asn Thr Tyr Trp Gly Leu Leu Asp Ser Glu Asp Ser Arg Leu 
385                 390                 395                 400 


Ser Cys Ser Pro Cys Ser Thr Thr Cys Thr Ser Ser Asn Thr Cys Glu 
                405                 410                 415     


Pro Cys Ser Ala Tyr Val Ile Cys Thr Val Glu Asn Cys Cys Leu 
            420                 425                 430     


<210> 7023
<211> 156
<212> PRT
<213> Homo sapiens

<400> 7023
Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Gly Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly 
            20                  25                  30          


Ser Ser Cys Cys Val Pro Ile Cys Cys Cys Lys Pro Val Cys Cys Cys 
        35                  40                  45              


Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys 
    50                  55                  60                  


Gly Gly Cys Gly Ser Cys Gly Ser Ser Lys Gly Gly Cys Gly Ser Cys 
65                  70                  75                  80  


Gly Cys Ser Gln Ser Asn Cys Cys Lys Pro Cys Cys Ser Ser Ser Gly 
                85                  90                  95      


Cys Gly Ser Phe Cys Cys Gln Ser Ser Cys Ser Lys Pro Cys Cys Cys 
            100                 105                 110         


Gln Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln 
        115                 120                 125             


Ser Ser Cys Cys Gln Ser Ser Cys Phe Lys Pro Cys Cys Cys Gln Ser 
    130                 135                 140                 


Ser Cys Cys Val Pro Val Cys Cys Gln Cys Lys Ile 
145                 150                 155     


<210> 7024
<211> 202
<212> PRT
<213> Homo sapiens

<400> 7024
Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Tyr Gly 
            20                  25                  30          


Ser Gly Cys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Val Cys Cys 
        35                  40                  45              


Cys Lys Pro Val Cys Cys Cys Val Pro Ala Cys Ser Cys Ser Ser Cys 
    50                  55                  60                  


Gly Ser Cys Gly Gly Ser Lys Gly Asp Cys Gly Ser Cys Gly Gly Ser 
65                  70                  75                  80  


Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser 
                85                  90                  95      


Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly 
            100                 105                 110         


Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly 
        115                 120                 125             


Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln Cys Asn Cys 
    130                 135                 140                 


Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Cys Cys Gln Ser 
145                 150                 155                 160 


Ser Cys Cys Asn Pro Cys Cys Cys Gln Ser Ser Cys Cys Val Pro Val 
                165                 170                 175     


Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln Ser Ser Cys 
            180                 185                 190         


Cys Val Pro Val Cys Cys Gln Cys Lys Ile 
        195                 200         


<210> 7025
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7025
Met Gly Cys Cys Gly Cys Ser Glu Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly 
            20                  25                  30          


Ser Ser Cys Cys Val Pro Val Cys Cys Cys Lys Pro Val Cys Cys Cys 
        35                  40                  45              


Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys 
    50                  55                  60                  


Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln Cys Ser 
                85                  90                  95      


Cys Tyr Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys 
            100                 105                 110         


Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln Ser Ser Cys Cys Lys 
        115                 120                 125             


Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser 
    130                 135                 140                 


Cys Cys Asn Pro Cys Cys Ser Gln Ser Ser Cys Cys Val Pro Val Cys 
145                 150                 155                 160 


Cys Gln Cys Lys Ile 
                165 


<210> 7026
<211> 1034
<212> PRT
<213> Homo sapiens

<400> 7026
Met Ala Ser Val Phe Met Cys Gly Val Glu Asp Leu Leu Phe Ser Gly 
1               5                   10                  15      


Ser Arg Phe Val Trp Asn Leu Thr Val Ser Thr Leu Arg Arg Trp Tyr 
            20                  25                  30          


Thr Glu Arg Leu Arg Ala Cys His Gln Val Leu Arg Thr Trp Cys Gly 
        35                  40                  45              


Leu Gln Asp Val Tyr Gln Met Thr Glu Gly Arg His Cys Gln Val His 
    50                  55                  60                  


Leu Leu Asp Asp Arg Arg Leu Glu Leu Leu Val Gln Pro Lys Leu Leu 
65                  70                  75                  80  


Ala Arg Glu Leu Leu Asp Leu Val Ala Ser His Phe Asn Leu Lys Glu 
                85                  90                  95      


Lys Glu Tyr Phe Gly Ile Thr Phe Ile Asp Asp Thr Gly Gln Gln Asn 
            100                 105                 110         


Trp Leu Gln Leu Asp His Arg Val Leu Asp His Asp Leu Pro Lys Lys 
        115                 120                 125             


Pro Gly Pro Thr Ile Leu His Phe Ala Val Arg Phe Tyr Ile Glu Ser 
    130                 135                 140                 


Ile Ser Phe Leu Lys Asp Lys Thr Thr Val Glu Leu Phe Phe Leu Asn 
145                 150                 155                 160 


Ala Lys Ala Cys Val His Lys Gly Gln Ile Glu Val Glu Ser Glu Thr 
                165                 170                 175     


Ile Phe Lys Leu Ala Ala Phe Ile Leu Gln Glu Ala Lys Gly Asp Tyr 
            180                 185                 190         


Thr Ser Asp Glu Asn Ala Arg Lys Asp Leu Lys Thr Leu Pro Ala Phe 
        195                 200                 205             


Pro Thr Lys Thr Leu Gln Glu His Pro Ser Leu Ala Tyr Cys Glu Asp 
    210                 215                 220                 


Arg Val Ile Glu His Tyr Leu Lys Ile Lys Gly Leu Thr Arg Gly Gln 
225                 230                 235                 240 


Ala Val Val Gln Tyr Met Lys Ile Val Glu Ala Leu Pro Thr Tyr Gly 
                245                 250                 255     


Val His Tyr Tyr Ala Val Lys Asp Lys Gln Gly Leu Pro Trp Trp Leu 
            260                 265                 270         


Gly Ile Ser Tyr Lys Gly Ile Gly Gln Tyr Asp Ile Gln Asp Lys Val 
        275                 280                 285             


Lys Pro Arg Lys Leu Phe Gln Trp Lys Gln Leu Glu Asn Leu Tyr Phe 
    290                 295                 300                 


Arg Glu Lys Lys Phe Ala Val Glu Val His Asp Pro Arg Arg Ile Ser 
305                 310                 315                 320 


Val Ser Arg Arg Thr Phe Gly Gln Ser Gly Leu Phe Val Gln Thr Trp 
                325                 330                 335     


Tyr Ala Asn Ser Ser Leu Ile Lys Ser Ile Trp Val Met Ala Ile Ser 
            340                 345                 350         


Gln His Gln Phe Tyr Leu Asp Arg Lys Gln Ser Lys Ala Lys Ile Pro 
        355                 360                 365             


Ser Ala Arg Ser Leu Asp Glu Ile Ala Met Asp Leu Thr Glu Thr Gly 
    370                 375                 380                 


Thr Gln Arg Ala Ser Lys Leu Val Thr Leu Glu Thr Lys Ser Gln Phe 
385                 390                 395                 400 


Ile Met Ala Ser Asn Gly Ser Leu Ile Ser Ser Gly Ser Gln Asp Ser 
                405                 410                 415     


Glu Val Ser Glu Glu Gln Lys Arg Glu Lys Ile Leu Glu Leu Lys Lys 
            420                 425                 430         


Lys Glu Lys Leu Leu Gln Glu Lys Leu Leu Lys Lys Val Glu Glu Leu 
        435                 440                 445             


Lys Lys Ile Cys Leu Arg Glu Ala Glu Leu Thr Gly Lys Met Pro Lys 
    450                 455                 460                 


Glu Tyr Pro Leu Asn Ile Gly Glu Lys Pro Pro Gln Val Arg Arg Arg 
465                 470                 475                 480 


Val Gly Thr Ala Phe Lys Leu Asp Asp Asn Leu Leu Pro Ser Glu Glu 
                485                 490                 495     


Asp Pro Ala Leu Gln Glu Leu Glu Ser Asn Phe Leu Ile Gln Gln Lys 
            500                 505                 510         


Leu Val Glu Ala Ala Lys Lys Leu Ala Asn Glu Pro Asp Leu Cys Lys 
        515                 520                 525             


Thr Val Lys Lys Lys Arg Lys Gln Asp Tyr Thr Asp Ala Met Lys Lys 
    530                 535                 540                 


Leu Gln Glu Ile Glu Asn Ala Ile Asn Glu Tyr Arg Ile Arg Cys Gly 
545                 550                 555                 560 


Lys Lys Pro Ser Gln Lys Ala Thr Val Leu Pro Glu Asp Ile Ile Pro 
                565                 570                 575     


Ser Glu Ser Ser Ser Leu Ser Asp Thr Thr Thr Tyr Asp Asp Pro Ser 
            580                 585                 590         


Asp Ala Phe Thr Phe Pro Gly Gln Arg Ser Ser Ser Val Pro His Ser 
        595                 600                 605             


Pro Arg Ile Leu Pro Pro Lys Ser Leu Gly Ile Glu Arg Ile His Phe 
    610                 615                 620                 


Arg Lys Ser Ser Ile Asn Glu Gln Phe Val Asp Thr Arg Gln Ser Arg 
625                 630                 635                 640 


Glu Met Leu Ser Thr His Ser Ser Pro Tyr Lys Thr Leu Glu Arg Arg 
                645                 650                 655     


Pro Gln Gly Gly Arg Ser Met Pro Thr Thr Pro Val Leu Thr Arg Asn 
            660                 665                 670         


Ala Tyr Ser Ser Ser His Leu Glu Pro Glu Ser Ser Ser Gln His Cys 
        675                 680                 685             


Arg Gln Arg Ser Gly Ser Leu Glu Ser Gln Ser His Leu Leu Ser Glu 
    690                 695                 700                 


Met Asp Ser Asp Lys Pro Phe Phe Ser Leu Ser Lys Ser Gln Arg Ser 
705                 710                 715                 720 


Ser Ser Thr Glu Ile Leu Asp Asp Gly Ser Ser Tyr Thr Ser Gln Ser 
                725                 730                 735     


Ser Thr Glu Tyr Tyr Cys Val Thr Pro Val Thr Gly Pro Tyr Tyr Thr 
            740                 745                 750         


Thr Gln Thr Leu Asp Thr Arg Thr Arg Gly Arg Arg Arg Ser Lys Lys 
        755                 760                 765             


Gln Asn Val Ser Thr Ser Asn Ser Gly Ser Met Pro Asn Leu Ala Gln 
    770                 775                 780                 


Lys Asp Ser Leu Arg Asn Gly Val Tyr Ser Lys Ser Gln Glu Pro Pro 
785                 790                 795                 800 


Ser Ser Ser Tyr Tyr Ile Ala Gly Tyr Thr Pro Tyr Ala Glu Cys Asp 
                805                 810                 815     


Phe Tyr Tyr Ser Gly Gly Tyr Val Tyr Glu Asn Asp Thr Glu Gly Gln 
            820                 825                 830         


Tyr Ser Val Asn Pro Ser Tyr Arg Ser Ser Ala His Tyr Gly Tyr Glu 
        835                 840                 845             


Arg Gln Arg Asp Tyr Ser Arg Ser Phe His Glu Asp Glu Val Asp Arg 
    850                 855                 860                 


Val Pro His Asn Pro Tyr Ala Thr Leu Arg Leu Pro Arg Lys Ala Ala 
865                 870                 875                 880 


Ala Lys Ser Glu His Ile Thr Lys Asn Ile His Lys Ala Leu Val Ala 
                885                 890                 895     


Glu His Leu Arg Gly Trp Tyr Gln Arg Ala Ser Gly Gln Lys Asp Gln 
            900                 905                 910         


Gly His Ser Pro Gln Thr Ser Phe Asp Ser Asp Arg Gly Ser Gln Arg 
        915                 920                 925             


Cys Leu Gly Phe Ala Gly Leu Gln Val Pro Cys Ser Pro Ser Ser Arg 
    930                 935                 940                 


Ala Ser Ser Tyr Ser Ser Val Ser Ser Thr Asn Ala Ser Gly Asn Trp 
945                 950                 955                 960 


Arg Thr Gln Leu Thr Ile Gly Leu Ser Asp Tyr Glu Thr Pro Ala His 
                965                 970                 975     


Ser Ser Tyr Thr Ser Cys Tyr Gly Asn Val Tyr Asn Pro Leu Pro Ser 
            980                 985                 990         


Pro Ser Arg Gln Tyr Thr Glu Ile  Ser Gln Leu Asp Gly  Thr Asp Gly 
        995                 1000                 1005             


Asn Gln  Leu Glu Asp Asn Leu  Glu Ser Ser Glu Gln  Arg Leu Phe 
    1010                 1015                 1020             


Trp His  Glu Asp Ser Lys Pro  Gly Thr Leu Val 
    1025                 1030                 


<210> 7027
<211> 166
<212> PRT
<213> Homo sapiens

<400> 7027
Met Leu Ser Gln Ser Cys Asn Leu Asp Pro Leu Thr Glu Thr Tyr Gly 
1               5                   10                  15      


Ile Pro Phe Tyr Leu Gln Tyr Leu Ala His Trp Pro Glu Tyr Phe Ile 
            20                  25                  30          


Val Ala Glu Ala Pro Gly Gly Glu Leu Met Gly Tyr Ile Met Gly Lys 
        35                  40                  45              


Ala Glu Gly Ser Val Ala Arg Glu Glu Trp His Gly His Val Thr Ala 
    50                  55                  60                  


Leu Ser Val Ala Pro Glu Phe Arg Arg Leu Gly Leu Ala Ala Lys Leu 
65                  70                  75                  80  


Met Glu Leu Leu Glu Glu Ile Ser Glu Arg Lys Gly Gly Phe Phe Val 
                85                  90                  95      


Asp Leu Phe Val Arg Val Ser Asn Gln Val Ala Val Asn Met Tyr Lys 
            100                 105                 110         


Gln Leu Gly Tyr Ser Val Tyr Arg Thr Val Ile Glu Tyr Tyr Ser Ala 
        115                 120                 125             


Ser Asn Gly Glu Pro Asp Glu Asp Ala Tyr Asp Met Arg Lys Ala Leu 
    130                 135                 140                 


Ser Arg Asp Thr Glu Lys Lys Ser Ile Ile Pro Leu Pro His Pro Val 
145                 150                 155                 160 


Arg Pro Glu Asp Ile Glu 
                165     


<210> 7028
<211> 132
<212> PRT
<213> Homo sapiens

<400> 7028
Met Arg Ala Ser Pro Cys Ile Ser Gln Pro Ala Ala Ser Trp His Pro 
1               5                   10                  15      


Arg Pro Ser Ala Leu Arg Pro Thr Ala Gly Ser Gly Pro Asp Thr Arg 
            20                  25                  30          


Thr Pro Gly Thr Val Glu Asp Gly Ser Ala Pro Cys Pro Ala Phe Arg 
        35                  40                  45              


Ser Pro Ala Val Ser Pro Cys Gly Glu Glu Pro Cys Cys Phe Gln Ile 
    50                  55                  60                  


Ser Pro Ala Glu Glu Thr Leu Glu Leu Gly Arg Leu Val Ser Pro Gly 
65                  70                  75                  80  


Asn Cys Asp Thr Leu Ser Pro Arg Ala Ala Gly Phe Tyr Ala Cys His 
                85                  90                  95      


Val Arg Ser Leu Ile Pro Cys Arg Ser Thr Lys Gly Arg Trp Pro Leu 
            100                 105                 110         


Thr Ala Ser Ala Ala Gly Leu Ser Arg His Ala Gln Cys Gly Pro Ser 
        115                 120                 125             


Leu Gly Leu Gly 
    130         


<210> 7029
<211> 124
<212> PRT
<213> Homo sapiens

<400> 7029
Met Arg Ala Ser Pro Cys Ile Ser Gln Pro Ala Ala Ser Trp His Pro 
1               5                   10                  15      


Arg Pro Ser Ala Leu Arg Pro Thr Ala Gly Ser Gly Pro Asp Thr Arg 
            20                  25                  30          


Thr Pro Gly Thr Val Glu Asp Gly Ser Ala Pro Cys Pro Ala Phe Arg 
        35                  40                  45              


Ser Pro Ala Val Ser Pro Cys Gly Glu Glu Pro Cys Cys Phe Gln Ile 
    50                  55                  60                  


Ser Pro Ala Glu Glu Thr Leu Glu Leu Gly Arg Leu Val Ser Pro Gly 
65                  70                  75                  80  


Asn Cys Asp Thr Leu Ser Pro Arg Ala Ala Gly Phe Tyr Ala Cys His 
                85                  90                  95      


Val Arg Ser Leu Ile Pro Cys Arg Ser Thr Lys Gly Arg Trp Pro Leu 
            100                 105                 110         


Thr Ala Ser Ala Ala Gly Leu Ser Ser Phe Ser Gly 
        115                 120                 


<210> 7030
<211> 111
<212> PRT
<213> Homo sapiens

<400> 7030
Leu Met Asp Leu Asp Ser Gly Asp Val Lys Arg Arg Val His Leu Phe 
1               5                   10                  15      


Glu Thr Gln Arg Arg Thr Lys Glu Glu Asp Pro Ile Ile Pro Phe Ser 
            20                  25                  30          


Asp Gly Pro Ile Ile Ser Lys Trp Gly Ala Ile Ser Arg Ser Ser Arg 
        35                  40                  45              


Thr Gly Tyr His Thr Thr Asp Pro Val Gln Ala Thr Ala Ser Gln Gly 
    50                  55                  60                  


Ser Ala Thr Lys Pro Ile Ser Val Ser Gly Gly Val His Met Ala Thr 
65                  70                  75                  80  


Arg Pro His His Gln His Thr Met Leu Lys Gly Thr Asp Ser Leu Leu 
                85                  90                  95      


Leu Ile Tyr Leu Val Ile Glu Ser Ile Pro Val Leu Gly Thr Phe 
            100                 105                 110     


<210> 7031
<211> 132
<212> PRT
<213> Homo sapiens

<400> 7031
Met Arg Ala Ser Pro Cys Ile Ser Gln Pro Ala Ala Ser Trp His Pro 
1               5                   10                  15      


Arg Pro Ser Ala Leu Arg Pro Thr Ala Gly Ser Gly Pro Asp Thr Arg 
            20                  25                  30          


Thr Pro Gly Thr Val Glu Asp Gly Ser Ala Pro Cys Pro Ala Phe Arg 
        35                  40                  45              


Ser Pro Ala Val Ser Pro Cys Gly Glu Glu Pro Cys Cys Phe Gln Ile 
    50                  55                  60                  


Ser Pro Ala Glu Glu Thr Leu Glu Leu Gly Arg Leu Val Ser Pro Gly 
65                  70                  75                  80  


Asn Cys Asp Thr Leu Ser Pro Arg Ala Ala Gly Phe Tyr Ala Cys His 
                85                  90                  95      


Val Arg Ser Leu Ile Pro Cys Arg Ser Thr Lys Gly Arg Trp Pro Leu 
            100                 105                 110         


Thr Ala Ser Ala Ala Gly Leu Ser Arg His Ala Gln Cys Gly Pro Ser 
        115                 120                 125             


Leu Gly Leu Gly 
    130         


<210> 7032
<211> 124
<212> PRT
<213> Homo sapiens

<400> 7032
Met Arg Ala Ser Pro Cys Ile Ser Gln Pro Ala Ala Ser Trp His Pro 
1               5                   10                  15      


Arg Pro Ser Ala Leu Arg Pro Thr Ala Gly Ser Gly Pro Asp Thr Arg 
            20                  25                  30          


Thr Pro Gly Thr Val Glu Asp Gly Ser Ala Pro Cys Pro Ala Phe Arg 
        35                  40                  45              


Ser Pro Ala Val Ser Pro Cys Gly Glu Glu Pro Cys Cys Phe Gln Ile 
    50                  55                  60                  


Ser Pro Ala Glu Glu Thr Leu Glu Leu Gly Arg Leu Val Ser Pro Gly 
65                  70                  75                  80  


Asn Cys Asp Thr Leu Ser Pro Arg Ala Ala Gly Phe Tyr Ala Cys His 
                85                  90                  95      


Val Arg Ser Leu Ile Pro Cys Arg Ser Thr Lys Gly Arg Trp Pro Leu 
            100                 105                 110         


Thr Ala Ser Ala Ala Gly Leu Ser Ser Phe Ser Gly 
        115                 120                 


<210> 7033
<211> 345
<212> PRT
<213> Homo sapiens

<400> 7033
Met Leu Pro Asn Thr Gly Arg Leu Ala Gly Cys Thr Val Phe Ile Thr 
1               5                   10                  15      


Gly Ala Ser Arg Gly Ile Gly Lys Ala Ile Ala Leu Lys Ala Ala Lys 
            20                  25                  30          


Asp Gly Ala Asn Ile Val Ile Ala Ala Lys Thr Ala Gln Pro His Pro 
        35                  40                  45              


Lys Leu Leu Gly Thr Ile Tyr Thr Ala Ala Glu Glu Ile Glu Ala Val 
    50                  55                  60                  


Gly Gly Lys Ala Leu Pro Cys Ile Val Asp Val Arg Asp Glu Gln Gln 
65                  70                  75                  80  


Ile Ser Ala Ala Val Glu Lys Ala Ile Lys Lys Phe Gly Ala Tyr Thr 
                85                  90                  95      


Ile Ala Lys Tyr Gly Met Ser Met Tyr Val Leu Gly Met Ala Glu Glu 
            100                 105                 110         


Phe Lys Gly Glu Ile Ala Val Asn Ala Leu Trp Pro Lys Thr Ala Ile 
        115                 120                 125             


His Thr Ala Ala Met Asp Met Leu Gly Gly Pro Gly Ile Glu Ser Gln 
    130                 135                 140                 


Cys Arg Lys Val Asp Ile Ile Ala Asp Ala Ala Tyr Ser Ile Phe Gln 
145                 150                 155                 160 


Lys Pro Lys Ser Phe Thr Gly Asn Phe Val Ile Asp Glu Asn Ile Leu 
                165                 170                 175     


Lys Glu Glu Gly Ile Glu Asn Phe Asp Val Tyr Ala Ile Lys Pro Gly 
            180                 185                 190         


His Pro Leu Gln Pro Asp Phe Phe Leu Asp Glu Tyr Pro Glu Ala Val 
        195                 200                 205             


Ser Lys Lys Val Glu Ser Thr Gly Ala Val Pro Glu Phe Lys Glu Glu 
    210                 215                 220                 


Lys Leu Gln Leu Gln Pro Lys Pro Arg Ser Gly Ala Val Glu Glu Thr 
225                 230                 235                 240 


Phe Arg Ile Val Lys Asp Ser Leu Ser Asp Asp Val Val Lys Ala Thr 
                245                 250                 255     


Gln Ala Ile Tyr Leu Phe Glu Leu Ser Gly Glu Asp Gly Gly Thr Trp 
            260                 265                 270         


Phe Leu Asp Leu Lys Ser Lys Gly Gly Asn Val Gly Tyr Gly Glu Pro 
        275                 280                 285             


Ser Asp Gln Ala Asp Val Val Met Ser Met Thr Thr Asp Asp Phe Val 
    290                 295                 300                 


Lys Met Phe Ser Gly Lys Leu Lys Pro Thr Met Ala Phe Met Ser Gly 
305                 310                 315                 320 


Lys Leu Lys Ile Lys Gly Asn Met Ala Leu Ala Ile Lys Leu Glu Lys 
                325                 330                 335     


Leu Met Asn Gln Met Asn Ala Arg Leu 
            340                 345 


<210> 7034
<211> 418
<212> PRT
<213> Homo sapiens

<400> 7034
Met Leu Pro Asn Thr Gly Arg Leu Ala Gly Cys Thr Val Phe Ile Thr 
1               5                   10                  15      


Gly Ala Ser Arg Gly Ile Gly Lys Ala Ile Ala Leu Lys Ala Ala Lys 
            20                  25                  30          


Asp Gly Ala Asn Ile Val Ile Ala Ala Lys Thr Ala Gln Pro His Pro 
        35                  40                  45              


Lys Leu Leu Gly Thr Ile Tyr Thr Ala Ala Glu Glu Ile Glu Ala Val 
    50                  55                  60                  


Gly Gly Lys Ala Leu Pro Cys Ile Val Asp Val Arg Asp Glu Gln Gln 
65                  70                  75                  80  


Ile Ser Ala Ala Val Glu Lys Ala Ile Lys Lys Phe Gly Gly Ile Asp 
                85                  90                  95      


Ile Leu Val Asn Asn Ala Ser Ala Ile Ser Leu Thr Asn Thr Leu Asp 
            100                 105                 110         


Thr Pro Thr Lys Arg Leu Asp Leu Met Met Asn Val Asn Thr Arg Gly 
        115                 120                 125             


Thr Tyr Leu Ala Ser Lys Ala Cys Ile Pro Tyr Leu Lys Lys Ser Lys 
    130                 135                 140                 


Val Ala His Ile Leu Asn Ile Ser Pro Pro Leu Asn Leu Asn Pro Val 
145                 150                 155                 160 


Trp Phe Lys Gln His Cys Ala Tyr Thr Ile Ala Lys Tyr Gly Met Ser 
                165                 170                 175     


Met Tyr Val Leu Gly Met Ala Glu Glu Phe Lys Gly Glu Ile Ala Val 
            180                 185                 190         


Asn Ala Leu Trp Pro Lys Thr Ala Ile His Thr Ala Ala Met Asp Met 
        195                 200                 205             


Leu Gly Gly Pro Gly Ile Glu Ser Gln Cys Arg Lys Val Asp Ile Ile 
    210                 215                 220                 


Ala Asp Ala Ala Tyr Ser Ile Phe Gln Lys Pro Lys Ser Phe Thr Gly 
225                 230                 235                 240 


Asn Phe Val Ile Asp Glu Asn Ile Leu Lys Glu Glu Gly Ile Glu Asn 
                245                 250                 255     


Phe Asp Val Tyr Ala Ile Lys Pro Gly His Pro Leu Gln Pro Asp Phe 
            260                 265                 270         


Phe Leu Asp Glu Tyr Pro Glu Ala Val Ser Lys Lys Val Glu Ser Thr 
        275                 280                 285             


Gly Ala Val Pro Glu Phe Lys Glu Glu Lys Leu Gln Leu Gln Pro Lys 
    290                 295                 300                 


Pro Arg Ser Gly Ala Val Glu Glu Thr Phe Arg Ile Val Lys Asp Ser 
305                 310                 315                 320 


Leu Ser Asp Asp Val Val Lys Ala Thr Gln Ala Ile Tyr Leu Phe Glu 
                325                 330                 335     


Leu Ser Gly Glu Asp Gly Gly Thr Trp Phe Leu Asp Leu Lys Ser Lys 
            340                 345                 350         


Gly Gly Asn Val Gly Tyr Gly Glu Pro Ser Asp Gln Ala Asp Val Val 
        355                 360                 365             


Met Ser Met Thr Thr Asp Asp Phe Val Lys Met Phe Ser Gly Lys Leu 
    370                 375                 380                 


Lys Pro Thr Met Ala Phe Met Ser Gly Lys Leu Lys Ile Lys Gly Asn 
385                 390                 395                 400 


Met Ala Leu Ala Ile Lys Leu Glu Lys Leu Met Asn Gln Met Asn Ala 
                405                 410                 415     


Arg Leu 
        


<210> 7035
<211> 358
<212> PRT
<213> Homo sapiens

<400> 7035
Met Pro Gly Cys Glu Leu Pro Val Gly Thr Cys Pro Asp Met Cys Pro 
1               5                   10                  15      


Ala Ala Glu Arg Ala Gln Arg Glu Arg Glu His Arg Leu His Arg Leu 
            20                  25                  30          


Glu Val Val Pro Gly Cys Arg Gln Asp Pro Pro Arg Ala Asp Pro Gln 
        35                  40                  45              


Arg Ala Val Lys Glu Tyr Ser Arg Pro Ala Ala Gly Lys Pro Arg Pro 
    50                  55                  60                  


Pro Pro Ser Gln Leu Arg Pro Pro Ser Val Leu Leu Ala Thr Val Arg 
65                  70                  75                  80  


Tyr Leu Ala Gly Glu Val Ala Glu Ser Ala Asp Ile Ala Arg Ala Glu 
                85                  90                  95      


Val Ala Ser Phe Val Ala Asp Arg Leu Arg Ala Val Leu Leu Asp Leu 
            100                 105                 110         


Ala Leu Gln Gly Ala Gly Asp Ala Glu Ala Ala Val Val Leu Glu Ala 
        115                 120                 125             


Ala Leu Ala Thr Leu Leu Thr Val Val Ala Arg Leu Gly Pro Asp Ala 
    130                 135                 140                 


Ala Arg Gly Pro Ala Asp Pro Val Leu Leu Gln Ala Gln Val Gln Glu 
145                 150                 155                 160 


Gly Phe Gly Ser Leu Arg Arg Cys Tyr Ala Arg Gly Ala Gly Pro His 
                165                 170                 175     


Pro Arg Gln Pro Ala Phe Gln Gly Leu Phe Leu Leu Tyr Asn Leu Gly 
            180                 185                 190         


Ser Val Glu Ala Leu His Glu Val Leu Gln Leu Pro Ala Ala Leu Arg 
        195                 200                 205             


Ala Cys Pro Pro Leu Arg Lys Ala Leu Ala Val Asp Ala Ala Phe Arg 
    210                 215                 220                 


Glu Gly Asn Ala Ala Arg Leu Phe Arg Leu Leu Gln Thr Leu Pro Tyr 
225                 230                 235                 240 


Leu Pro Ser Cys Ala Val Gln Cys His Val Gly His Ala Arg Arg Glu 
                245                 250                 255     


Ala Leu Ala Arg Phe Ala Arg Ala Phe Ser Thr Pro Lys Gly Gln Thr 
            260                 265                 270         


Leu Pro Leu Gly Phe Met Val Asn Leu Leu Ala Leu Asp Gly Leu Arg 
        275                 280                 285             


Glu Ala Arg Asp Leu Cys Gln Ala His Gly Leu Pro Leu Asp Gly Glu 
    290                 295                 300                 


Glu Arg Val Val Phe Leu Arg Gly Arg Tyr Val Glu Glu Gly Leu Pro 
305                 310                 315                 320 


Pro Ala Ser Thr Cys Lys Val Leu Val Glu Ser Lys Leu Arg Gly Arg 
                325                 330                 335     


Thr Leu Glu Glu Val Val Met Ala Glu Glu Glu Asp Glu Gly Thr Asp 
            340                 345                 350         


Arg Pro Gly Ser Pro Ala 
        355             


<210> 7036
<211> 49
<212> PRT
<213> Homo sapiens

<400> 7036
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met 
    


<210> 7037
<211> 865
<212> PRT
<213> Homo sapiens

<400> 7037
Met Pro Ala Val Ser Leu Pro Pro Lys Glu Asn Ala Leu Phe Lys Arg 
1               5                   10                  15      


Ile Leu Arg Cys Tyr Glu His Lys Gln Tyr Arg Asn Gly Leu Lys Phe 
            20                  25                  30          


Cys Lys Gln Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr 
        35                  40                  45              


Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu 
    50                  55                  60                  


Ala Tyr Glu Leu Val Arg Arg Gly Leu Arg Asn Asp Leu Lys Ser His 
65                  70                  75                  80  


Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr 
                85                  90                  95      


Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Trp Asp Lys Asp 
            100                 105                 110         


Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg 
        115                 120                 125             


Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg 
    130                 135                 140                 


Pro Ala Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu 
145                 150                 155                 160 


Leu Glu Asp Tyr Glu Met Ala Ala Lys Ile Leu Glu Glu Phe Arg Lys 
                165                 170                 175     


Thr Gln Gln Thr Ser Pro Asp Lys Val Asp Tyr Glu Tyr Ser Glu Leu 
            180                 185                 190         


Leu Leu Tyr Gln Asn Gln Val Leu Arg Glu Ala Gly Leu Tyr Arg Glu 
        195                 200                 205             


Ala Leu Glu His Leu Cys Thr Tyr Glu Lys Gln Ile Cys Asp Lys Leu 
    210                 215                 220                 


Ala Val Glu Glu Thr Lys Gly Glu Leu Leu Leu Gln Leu Cys Arg Leu 
225                 230                 235                 240 


Glu Asp Ala Ala Asp Val Tyr Arg Gly Leu Gln Glu Arg Asn Pro Glu 
                245                 250                 255     


Asn Trp Ala Tyr Tyr Lys Gly Leu Glu Lys Ala Leu Lys Pro Ala Asn 
            260                 265                 270         


Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys Tyr Pro 
        275                 280                 285             


Arg Gly Leu Val Pro Arg Arg Leu Pro Leu Asn Phe Leu Ser Gly Glu 
    290                 295                 300                 


Lys Phe Lys Glu Cys Leu Asp Lys Phe Leu Arg Met Asn Phe Ser Lys 
305                 310                 315                 320 


Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Lys Asp Lys 
                325                 330                 335     


Glu Lys Val Ala Ile Ile Glu Glu Leu Val Val Gly Tyr Glu Thr Ser 
            340                 345                 350         


Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys Glu Glu 
        355                 360                 365             


Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln His Tyr 
    370                 375                 380                 


Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn Thr Ala 
385                 390                 395                 400 


Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys Ala Lys 
                405                 410                 415     


Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp Met Asp 
            420                 425                 430         


Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
        435                 440                 445             


Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu Glu Met 
    450                 455                 460                 


Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn Leu Asn 
465                 470                 475                 480 


Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala Tyr Lys 
                485                 490                 495     


Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu Ile Glu 
            500                 505                 510         


Arg His Phe Ile Glu Ile Thr Asp Asp Gln Phe Asp Phe His Thr Tyr 
        515                 520                 525             


Cys Met Arg Lys Ile Thr Leu Arg Ser Tyr Val Asp Leu Leu Lys Leu 
    530                 535                 540                 


Glu Asp Val Leu Arg Gln His Pro Phe Tyr Phe Lys Ala Ala Arg Ile 
545                 550                 555                 560 


Ala Ile Glu Ile Tyr Leu Lys Leu His Asp Asn Pro Leu Thr Asp Glu 
                565                 570                 575     


Asn Lys Glu His Glu Ala Asp Thr Ala Asn Met Ser Asp Lys Glu Leu 
            580                 585                 590         


Lys Lys Leu Arg Asn Lys Gln Arg Arg Ala Gln Lys Lys Ala Gln Ile 
        595                 600                 605             


Glu Glu Glu Lys Lys Asn Ala Glu Lys Glu Lys Gln Gln Arg Asn Gln 
    610                 615                 620                 


Lys Lys Lys Lys Asp Asp Asp Asp Glu Glu Ile Gly Gly Pro Lys Glu 
625                 630                 635                 640 


Glu Leu Ile Pro Glu Lys Leu Ala Lys Val Glu Thr Pro Leu Glu Glu 
                645                 650                 655     


Ala Ile Lys Phe Leu Thr Pro Leu Lys Asn Leu Val Lys Asn Lys Ile 
            660                 665                 670         


Glu Thr His Leu Phe Ala Phe Glu Ile Tyr Phe Arg Lys Glu Lys Phe 
        675                 680                 685             


Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asp Ser Ser 
    690                 695                 700                 


His Pro Trp Leu His Glu Cys Met Ile Arg Leu Phe Asn Thr Val Cys 
705                 710                 715                 720 


Glu Ser Lys Asp Leu Ser Asp Thr Val Arg Thr Val Leu Lys Gln Glu 
                725                 730                 735     


Met Asn Arg Leu Phe Gly Ala Thr Asn Pro Lys Asn Phe Asn Glu Thr 
            740                 745                 750         


Phe Leu Lys Arg Asn Ser Asp Ser Leu Pro His Arg Leu Ser Ala Ala 
        755                 760                 765             


Lys Met Val Tyr Tyr Leu Asp Pro Ser Ser Gln Lys Arg Ala Ile Glu 
    770                 775                 780                 


Leu Ala Thr Thr Leu Asp Glu Ser Leu Thr Asn Arg Asn Leu Gln Thr 
785                 790                 795                 800 


Cys Met Glu Val Leu Glu Ala Leu Tyr Asp Gly Ser Leu Gly Asp Cys 
                805                 810                 815     


Lys Glu Ala Ala Glu Ile Tyr Arg Ala Asn Cys His Lys Leu Phe Pro 
            820                 825                 830         


Tyr Ala Leu Ala Phe Met Pro Pro Gly Tyr Glu Glu Asp Met Lys Ile 
        835                 840                 845             


Thr Val Asn Gly Asp Ser Ser Ala Glu Ala Glu Glu Leu Ala Asn Glu 
    850                 855                 860                 


Ile 
865 


<210> 7038
<211> 598
<212> PRT
<213> Homo sapiens

<400> 7038
Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu 
1               5                   10                  15      


Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser 
            20                  25                  30          


Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His 
        35                  40                  45              


Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro 
    50                  55                  60                  


Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn 
65                  70                  75                  80  


Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val 
                85                  90                  95      


Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr 
            100                 105                 110         


Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys 
        115                 120                 125             


Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp 
    130                 135                 140                 


Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys 
145                 150                 155                 160 


Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg 
                165                 170                 175     


Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser 
            180                 185                 190         


Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val 
        195                 200                 205             


Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu 
    210                 215                 220                 


Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys 
225                 230                 235                 240 


Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe 
                245                 250                 255     


Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr 
            260                 265                 270         


Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu 
        275                 280                 285             


Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu 
    290                 295                 300                 


Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro 
305                 310                 315                 320 


Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val 
                325                 330                 335     


Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr 
            340                 345                 350         


Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe 
        355                 360                 365             


Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe 
    370                 375                 380                 


Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu 
385                 390                 395                 400 


Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys 
                405                 410                 415     


Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala 
            420                 425                 430         


Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe 
        435                 440                 445             


Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala 
    450                 455                 460                 


Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys 
465                 470                 475                 480 


Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala 
                485                 490                 495     


Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr 
            500                 505                 510         


Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly 
        515                 520                 525             


Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys 
    530                 535                 540                 


Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser 
545                 550                 555                 560 


Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser 
                565                 570                 575     


Gly Arg Ala Ile Arg Lys Arg Glu Val Glu Thr Gly Asp Met Ser Trp 
            580                 585                 590         


Leu Thr Gly Lys Gly Ser 
        595             


<210> 7039
<211> 605
<212> PRT
<213> Homo sapiens

<400> 7039
Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu 
1               5                   10                  15      


Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser 
            20                  25                  30          


Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His 
        35                  40                  45              


Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro 
    50                  55                  60                  


Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn 
65                  70                  75                  80  


Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val 
                85                  90                  95      


Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr 
            100                 105                 110         


Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys 
        115                 120                 125             


Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp 
    130                 135                 140                 


Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys 
145                 150                 155                 160 


Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg 
                165                 170                 175     


Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser 
            180                 185                 190         


Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val 
        195                 200                 205             


Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu 
    210                 215                 220                 


Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys 
225                 230                 235                 240 


Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe 
                245                 250                 255     


Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr 
            260                 265                 270         


Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu 
        275                 280                 285             


Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu 
    290                 295                 300                 


Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro 
305                 310                 315                 320 


Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val 
                325                 330                 335     


Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr 
            340                 345                 350         


Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe 
        355                 360                 365             


Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe 
    370                 375                 380                 


Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu 
385                 390                 395                 400 


Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys 
                405                 410                 415     


Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala 
            420                 425                 430         


Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe 
        435                 440                 445             


Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala 
    450                 455                 460                 


Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys 
465                 470                 475                 480 


Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala 
                485                 490                 495     


Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr 
            500                 505                 510         


Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly 
        515                 520                 525             


Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys 
    530                 535                 540                 


Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser 
545                 550                 555                 560 


Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser 
                565                 570                 575     


Gly Arg Ala Ile Arg Lys Arg Glu Val Glu Leu Phe Val Leu His Ser 
            580                 585                 590         


Lys Thr Gly Asp Met Ser Trp Leu Thr Gly Lys Gly Ser 
        595                 600                 605 


<210> 7040
<211> 457
<212> PRT
<213> Homo sapiens

<400> 7040
Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Gly Arg Phe Gln Lys Phe 
        435                 440                 445             


Asn Tyr Val Glu Ala Ser Gly Thr Phe 
    450                 455         


<210> 7041
<211> 457
<212> PRT
<213> Homo sapiens

<400> 7041
Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Gly Arg Phe Gln Lys Phe 
        435                 440                 445             


Asn Tyr Val Glu Ala Ser Gly Thr Phe 
    450                 455         


<210> 7042
<211> 523
<212> PRT
<213> Homo sapiens

<400> 7042
Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Leu Phe Val Asp Lys Asp 
        435                 440                 445             


Thr Ile Val Asn Ala Val Gly Ala Ser His Asp Ile His Leu Leu Lys 
    450                 455                 460                 


Ile Asp Asn Arg Glu Asp Glu Leu Val Thr Arg Ile Asn Ser Trp Cys 
465                 470                 475                 480 


Thr Arg Leu Ile Asp Arg Ile His Lys Asp Glu Ile Met Arg Asn Arg 
                485                 490                 495     


Lys Arg Val Lys Glu Ile Asn Gln Tyr Ile Asp His Met Gln Ser Glu 
            500                 505                 510         


Leu Asp Asn Leu Glu Cys Gly Asp Ile Leu Asp 
        515                 520             


<210> 7043
<211> 523
<212> PRT
<213> Homo sapiens

<400> 7043
Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Leu Phe Val Asp Lys Asp 
        435                 440                 445             


Thr Ile Val Asn Ala Val Gly Ala Ser His Asp Ile His Leu Leu Lys 
    450                 455                 460                 


Ile Asp Asn Arg Glu Asp Glu Leu Val Thr Arg Ile Asn Ser Trp Cys 
465                 470                 475                 480 


Thr Arg Leu Ile Asp Arg Ile His Lys Asp Glu Ile Met Arg Asn Arg 
                485                 490                 495     


Lys Arg Val Lys Glu Ile Asn Gln Tyr Ile Asp His Met Gln Ser Glu 
            500                 505                 510         


Leu Asp Asn Leu Glu Cys Gly Asp Ile Leu Asp 
        515                 520             


<210> 7044
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7044
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 7045
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7045
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7046
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7046
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7047
<211> 1375
<212> PRT
<213> Homo sapiens

<400> 7047
Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Asp Val Phe 
1               5                   10                  15      


Trp Arg Cys Arg Gln Asn Ile Phe Asp Glu Met Lys Lys Lys Phe Leu 
            20                  25                  30          


Gln Ile Glu Asn Ala Ala Glu Glu Pro Arg Val Leu Cys Ile Ile Gln 
        35                  40                  45              


Asp Thr Thr Asn Ser Lys Thr Val Asn Glu Arg Ile Thr Leu Asn Leu 
    50                  55                  60                  


Pro Ala Ser Thr Pro Val Arg Lys Leu Phe Glu Asp Val Ala Asn Lys 
65                  70                  75                  80  


Val Gly Tyr Ile Asn Gly Thr Phe Asp Leu Val Trp Gly Asn Gly Ile 
                85                  90                  95      


Asn Thr Ala Asp Met Ala Pro Leu Asp His Thr Ser Asp Lys Ser Leu 
            100                 105                 110         


Leu Asp Ala Asn Phe Glu Pro Gly Lys Lys Asn Phe Leu His Leu Thr 
        115                 120                 125             


Asp Lys Asp Gly Glu Gln Pro Gln Ile Leu Leu Glu Asp Ser Ser Ala 
    130                 135                 140                 


Gly Glu Asp Ser Val His Asp Arg Phe Ile Gly Pro Leu Pro Arg Glu 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Thr Ser Asp Tyr Val Ser Gln Ser Tyr Ser Tyr 
                165                 170                 175     


Ser Ser Ile Leu Asn Lys Ser Glu Thr Gly Tyr Val Gly Leu Val Asn 
            180                 185                 190         


Gln Ala Met Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu Phe Met 
        195                 200                 205             


Thr Pro Glu Phe Arg Asn Ala Leu Tyr Lys Trp Glu Phe Glu Glu Ser 
    210                 215                 220                 


Glu Glu Asp Pro Val Thr Ser Ile Pro Tyr Gln Leu Gln Arg Leu Phe 
225                 230                 235                 240 


Val Leu Leu Gln Thr Ser Lys Lys Arg Ala Ile Glu Thr Thr Asp Val 
                245                 250                 255     


Thr Arg Ser Phe Gly Trp Asp Ser Ser Glu Ala Trp Gln Gln His Asp 
            260                 265                 270         


Val Gln Glu Leu Cys Arg Val Met Phe Asp Ala Leu Glu Gln Lys Trp 
        275                 280                 285             


Lys Gln Thr Glu Gln Ala Asp Leu Ile Asn Glu Leu Tyr Gln Gly Lys 
    290                 295                 300                 


Leu Lys Asp Tyr Val Arg Cys Leu Glu Cys Gly Tyr Glu Gly Trp Arg 
305                 310                 315                 320 


Ile Asp Thr Tyr Leu Asp Ile Pro Leu Val Ile Arg Pro Tyr Gly Ser 
                325                 330                 335     


Ser Gln Ala Phe Ala Ser Val Glu Glu Ala Leu His Ala Phe Ile Gln 
            340                 345                 350         


Pro Glu Ile Leu Asp Gly Pro Asn Gln Tyr Phe Cys Glu Arg Cys Lys 
        355                 360                 365             


Lys Lys Cys Asp Ala Arg Lys Gly Leu Arg Phe Leu His Phe Pro Tyr 
    370                 375                 380                 


Leu Leu Thr Leu Gln Leu Lys Arg Phe Asp Phe Asp Tyr Thr Thr Met 
385                 390                 395                 400 


His Arg Ile Lys Leu Asn Asp Arg Met Thr Phe Pro Glu Glu Leu Asp 
                405                 410                 415     


Met Ser Thr Phe Ile Asp Val Glu Asp Glu Lys Ser Pro Gln Thr Glu 
            420                 425                 430         


Ser Cys Thr Asp Ser Gly Ala Glu Asn Glu Gly Ser Cys His Ser Asp 
        435                 440                 445             


Gln Met Ser Asn Asp Phe Ser Asn Asp Asp Gly Val Asp Glu Gly Ile 
    450                 455                 460                 


Cys Leu Glu Thr Asn Ser Gly Thr Glu Lys Ile Ser Lys Ser Gly Leu 
465                 470                 475                 480 


Glu Lys Asn Ser Leu Ile Tyr Glu Leu Phe Ser Val Met Val His Ser 
                485                 490                 495     


Gly Ser Ala Ala Gly Gly His Tyr Tyr Ala Cys Ile Lys Ser Phe Ser 
            500                 505                 510         


Asp Glu Gln Trp Tyr Ser Phe Asn Asp Gln His Val Ser Arg Ile Thr 
        515                 520                 525             


Gln Glu Asp Ile Lys Lys Thr His Gly Gly Ser Ser Gly Ser Arg Gly 
    530                 535                 540                 


Tyr Tyr Ser Ser Ala Phe Ala Ser Ser Thr Asn Ala Tyr Met Leu Ile 
545                 550                 555                 560 


Tyr Arg Leu Lys Asp Pro Ala Arg Asn Ala Lys Phe Leu Glu Val Asp 
                565                 570                 575     


Glu Tyr Pro Glu His Ile Lys Asn Leu Val Gln Lys Glu Arg Glu Leu 
            580                 585                 590         


Glu Glu Gln Glu Lys Arg Gln Arg Glu Ile Glu Arg Asn Thr Cys Lys 
        595                 600                 605             


Ile Lys Leu Phe Cys Leu His Pro Thr Lys Gln Val Met Met Glu Asn 
    610                 615                 620                 


Lys Leu Glu Val His Lys Asp Lys Thr Leu Lys Glu Ala Val Glu Met 
625                 630                 635                 640 


Ala Tyr Lys Met Met Asp Leu Glu Glu Val Ile Pro Leu Asp Cys Cys 
                645                 650                 655     


Arg Leu Val Lys Tyr Asp Glu Phe His Asp Tyr Leu Glu Arg Ser Tyr 
            660                 665                 670         


Glu Gly Glu Glu Asp Thr Pro Met Gly Leu Leu Leu Gly Gly Val Lys 
        675                 680                 685             


Ser Thr Tyr Met Phe Asp Leu Leu Leu Glu Thr Arg Lys Pro Asp Gln 
    690                 695                 700                 


Val Phe Gln Ser Tyr Lys Pro Gly Glu Val Met Val Lys Val His Val 
705                 710                 715                 720 


Val Asp Leu Lys Ala Glu Ser Val Ala Ala Pro Ile Thr Val Arg Ala 
                725                 730                 735     


Tyr Leu Asn Gln Thr Val Thr Glu Phe Lys Gln Leu Ile Ser Lys Ala 
            740                 745                 750         


Ile His Leu Pro Ala Glu Thr Met Arg Ile Val Leu Glu Arg Cys Tyr 
        755                 760                 765             


Asn Asp Leu Arg Leu Leu Ser Val Ser Ser Lys Thr Leu Lys Ala Glu 
    770                 775                 780                 


Gly Phe Phe Arg Ser Asn Lys Val Phe Val Glu Ser Ser Glu Thr Leu 
785                 790                 795                 800 


Asp Tyr Gln Met Ala Phe Ala Asp Ser His Leu Trp Lys Leu Leu Asp 
                805                 810                 815     


Arg His Ala Asn Thr Ile Arg Leu Phe Val Leu Leu Pro Glu Gln Ser 
            820                 825                 830         


Pro Val Ser Tyr Ser Lys Arg Thr Ala Tyr Gln Lys Ala Gly Gly Asp 
        835                 840                 845             


Ser Gly Asn Val Asp Asp Asp Cys Glu Arg Val Lys Gly Pro Val Gly 
    850                 855                 860                 


Ser Leu Lys Ser Val Glu Ala Ile Leu Glu Glu Ser Thr Glu Lys Leu 
865                 870                 875                 880 


Lys Ser Leu Ser Leu Gln Gln Gln Gln Asp Gly Asp Asn Gly Asp Ser 
                885                 890                 895     


Ser Lys Ser Thr Glu Thr Ser Asp Phe Glu Asn Ile Glu Ser Pro Leu 
            900                 905                 910         


Asn Glu Arg Asp Ser Ser Ala Ser Val Asp Asn Arg Glu Leu Glu Gln 
        915                 920                 925             


His Ile Gln Thr Ser Asp Pro Glu Asn Phe Gln Ser Glu Glu Arg Ser 
    930                 935                 940                 


Asp Ser Asp Val Asn Asn Asp Arg Ser Thr Ser Ser Val Asp Ser Asp 
945                 950                 955                 960 


Ile Leu Ser Ser Ser His Ser Ser Asp Thr Leu Cys Asn Ala Asp Asn 
                965                 970                 975     


Ala Gln Ile Pro Leu Ala Asn Gly Leu Asp Ser His Ser Ile Thr Ser 
            980                 985                 990         


Ser Arg Arg Thr Lys Ala Asn Glu  Gly Lys Lys Glu Thr  Trp Asp Thr 
        995                 1000                 1005             


Ala Glu  Glu Asp Ser Gly Thr  Asp Ser Glu Tyr Asp  Glu Ser Gly 
    1010                 1015                 1020             


Lys Ser  Arg Gly Glu Met Gln  Tyr Met Tyr Phe Lys  Ala Glu Pro 
    1025                 1030                 1035             


Tyr Ala  Ala Asp Glu Gly Ser  Gly Glu Gly His Lys  Trp Leu Met 
    1040                 1045                 1050             


Val His  Val Asp Lys Arg Ile  Thr Leu Ala Ala Phe  Lys Gln His 
    1055                 1060                 1065             


Leu Glu  Pro Phe Val Gly Val  Leu Ser Ser His Phe  Lys Val Phe 
    1070                 1075                 1080             


Arg Val  Tyr Ala Ser Asn Gln  Glu Phe Glu Ser Val  Arg Leu Asn 
    1085                 1090                 1095             


Glu Thr  Leu Ser Ser Phe Ser  Asp Asp Asn Lys Ile  Thr Ile Arg 
    1100                 1105                 1110             


Leu Gly  Arg Ala Leu Lys Lys  Gly Glu Tyr Arg Val  Lys Val Tyr 
    1115                 1120                 1125             


Gln Leu  Leu Val Asn Glu Gln  Glu Pro Cys Lys Phe  Leu Leu Asp 
    1130                 1135                 1140             


Ala Val  Phe Ala Lys Gly Met  Thr Val Arg Gln Ser  Lys Glu Glu 
    1145                 1150                 1155             


Leu Ile  Pro Gln Leu Arg Glu  Gln Cys Gly Leu Glu  Leu Ser Ile 
    1160                 1165                 1170             


Asp Arg  Phe Arg Leu Arg Lys  Lys Thr Trp Lys Asn  Pro Gly Thr 
    1175                 1180                 1185             


Val Phe  Leu Asp Tyr His Ile  Tyr Glu Glu Asp Ile  Asn Ile Ser 
    1190                 1195                 1200             


Ser Asn  Trp Glu Val Phe Leu  Glu Val Leu Asp Gly  Val Glu Lys 
    1205                 1210                 1215             


Met Lys  Ser Met Ser Gln Leu  Ala Val Leu Ser Arg  Arg Trp Lys 
    1220                 1225                 1230             


Pro Ser  Glu Met Lys Leu Asp  Pro Phe Gln Glu Val  Val Leu Glu 
    1235                 1240                 1245             


Ser Ser  Ser Val Asp Glu Leu  Arg Glu Lys Leu Ser  Glu Ile Ser 
    1250                 1255                 1260             


Gly Ile  Pro Leu Asp Asp Ile  Glu Phe Ala Lys Gly  Arg Gly Thr 
    1265                 1270                 1275             


Phe Pro  Cys Asp Ile Ser Val  Leu Asp Ile His Gln  Asp Leu Asp 
    1280                 1285                 1290             


Trp Asn  Pro Lys Val Ser Thr  Leu Asn Val Trp Pro  Leu Tyr Ile 
    1295                 1300                 1305             


Cys Asp  Asp Gly Ala Val Ile  Phe Tyr Arg Asp Lys  Thr Glu Glu 
    1310                 1315                 1320             


Leu Met  Glu Leu Thr Asp Glu  Gln Arg Asn Glu Leu  Met Lys Lys 
    1325                 1330                 1335             


Glu Ser  Ser Arg Leu Gln Lys  Thr Gly His Arg Val  Thr Tyr Ser 
    1340                 1345                 1350             


Pro Arg  Lys Glu Lys Ala Leu  Lys Ile Tyr Leu Asp  Gly Ala Pro 
    1355                 1360                 1365             


Asn Lys  Asp Leu Thr Gln Asp  
    1370                 1375 


<210> 7048
<211> 199
<212> PRT
<213> Homo sapiens

<400> 7048
Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Pro His 
        195                 


<210> 7049
<211> 323
<212> PRT
<213> Homo sapiens

<400> 7049
Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala 
        195                 200                 205             


Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu 
    210                 215                 220                 


Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr 
225                 230                 235                 240 


Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg 
                245                 250                 255     


Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp 
            260                 265                 270         


Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr 
        275                 280                 285             


Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala 
    290                 295                 300                 


Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Gln 
            


<210> 7050
<211> 1512
<212> PRT
<213> Homo sapiens

<400> 7050
Met Ala Ala Ala Ala Gly Asn Arg Ala Ser Ser Ser Gly Phe Pro Gly 
1               5                   10                  15      


Ala Arg Ala Thr Ser Pro Glu Ala Gly Gly Gly Gly Gly Ala Leu Lys 
            20                  25                  30          


Ala Ser Ser Ala Pro Ala Ala Ala Ala Gly Leu Leu Arg Glu Ala Gly 
        35                  40                  45              


Ser Gly Gly Arg Glu Arg Ala Asp Trp Arg Arg Arg Gln Leu Arg Lys 
    50                  55                  60                  


Val Arg Ser Val Glu Leu Asp Gln Leu Pro Glu Gln Pro Leu Phe Leu 
65                  70                  75                  80  


Ala Ala Ser Pro Pro Ala Ser Ser Thr Ser Pro Ser Pro Glu Pro Ala 
                85                  90                  95      


Asp Ala Ala Gly Ser Gly Thr Gly Phe Gln Pro Val Ala Val Pro Pro 
            100                 105                 110         


Pro His Gly Ala Ala Ser Arg Gly Gly Ala His Leu Thr Glu Ser Val 
        115                 120                 125             


Ala Ala Pro Asp Ser Gly Ala Ser Ser Pro Ala Ala Ala Glu Pro Gly 
    130                 135                 140                 


Glu Lys Arg Ala Pro Ala Ala Glu Pro Ser Pro Ala Ala Ala Pro Ala 
145                 150                 155                 160 


Gly Arg Glu Met Glu Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met 
                165                 170                 175     


Asp Asp Arg Pro Glu Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr 
            180                 185                 190         


Cys Met Pro Ala Trp Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg 
        195                 200                 205             


Gly Pro Val Val Val Lys Pro Ile Pro Val Lys Gly Asp Gly Ser Glu 
    210                 215                 220                 


Met Asn His Leu Ala Ala Glu Ser Pro Gly Glu Val Gln Ala Ser Ala 
225                 230                 235                 240 


Ala Ser Pro Ala Ser Lys Gly Arg Arg Ser Pro Ser Pro Gly Asn Ser 
                245                 250                 255     


Pro Ser Gly Arg Thr Val Lys Ser Glu Ser Pro Gly Val Arg Arg Lys 
            260                 265                 270         


Arg Val Ser Pro Val Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg 
        275                 280                 285             


Arg Ala Pro Ser Pro Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr 
    290                 295                 300                 


Asn Arg Arg Val Asn Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln 
305                 310                 315                 320 


Gln Ile Gly Pro Asn Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn 
                325                 330                 335     


Lys Tyr Arg Val Phe Ile Gly Pro Gln Asn Cys Ser Cys Ala Arg Gly 
            340                 345                 350         


Thr Phe Cys Ile His Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu 
        355                 360                 365             


Glu Pro Ser Asp Pro Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu 
    370                 375                 380                 


Val Glu Ser Leu Phe Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile 
385                 390                 395                 400 


Lys Ala Pro Ser Arg Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser 
                405                 410                 415     


Asn Ser His Thr Leu Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu 
            420                 425                 430         


Asn Ser Ile Lys Asp Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu 
        435                 440                 445             


Gly Met Leu Asp Glu Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg 
    450                 455                 460                 


Asn Lys Leu His His His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg 
465                 470                 475                 480 


Arg Asn Arg Glu Pro Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg 
                485                 490                 495     


Ser His Asp Phe Tyr Ser His Glu Leu Ser Ser Pro Val Asp Ser Pro 
            500                 505                 510         


Ser Ser Leu Arg Ala Ala Gln Gln Gln Thr Val Gln Gln Gln Pro Leu 
        515                 520                 525             


Ala Gly Ser Arg Arg Asn Gln Glu Ser Asn Phe Asn Leu Thr His Tyr 
    530                 535                 540                 


Gly Thr Gln Gln Ile Pro Pro Ala Tyr Lys Asp Leu Ala Glu Pro Trp 
545                 550                 555                 560 


Ile Gln Val Phe Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn 
                565                 570                 575     


Trp Asn Val Arg Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser 
            580                 585                 590         


Gly Ala Leu Leu Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly 
        595                 600                 605             


Ser Ser Gly Ser Ser Pro Ser Gly Gly Ala Thr Ser Gly Ser Ser Gln 
    610                 615                 620                 


Thr Ser Ile Ser Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser 
625                 630                 635                 640 


Met Val Cys Ala Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys 
                645                 650                 655     


Thr Leu Arg Ala Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu 
            660                 665                 670         


Arg Ile Lys Leu Gln Arg Leu Leu Gln Pro Val Val Asp Thr Ile Leu 
        675                 680                 685             


Val Lys Cys Ala Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser 
    690                 695                 700                 


Thr Leu Leu Glu Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly 
705                 710                 715                 720 


Arg Glu Ile Leu Lys Ala Gly Ser Ile Gly Ile Gly Gly Val Asp Tyr 
                725                 730                 735     


Val Leu Asn Cys Ile Leu Gly Asn Gln Thr Glu Ser Asn Asn Trp Gln 
            740                 745                 750         


Glu Leu Leu Gly Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe 
        755                 760                 765             


Pro Ala Glu Phe Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala 
    770                 775                 780                 


Glu Pro Val Glu Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe 
785                 790                 795                 800 


Ala Leu Gln Ser Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser 
                805                 810                 815     


Arg Arg Ile Tyr Leu Ser Ser Ala Arg Met Val Thr Thr Val Pro His 
            820                 825                 830         


Val Phe Ser Lys Leu Leu Glu Met Leu Ser Val Ser Ser Ser Thr His 
        835                 840                 845             


Phe Thr Arg Met Arg Arg Arg Leu Met Ala Ile Ala Asp Glu Val Glu 
    850                 855                 860                 


Ile Ala Glu Ala Ile Gln Leu Gly Val Glu Asp Thr Leu Asp Gly Gln 
865                 870                 875                 880 


Gln Asp Ser Phe Leu Gln Ala Ser Val Pro Asn Asn Tyr Leu Glu Thr 
                885                 890                 895     


Thr Glu Asn Ser Ser Pro Glu Cys Thr Val His Leu Glu Lys Thr Gly 
            900                 905                 910         


Lys Gly Leu Cys Ala Thr Lys Leu Ser Ala Ser Ser Glu Asp Ile Ser 
        915                 920                 925             


Glu Arg Leu Ala Ser Ile Ser Val Gly Pro Ser Ser Ser Thr Thr Thr 
    930                 935                 940                 


Thr Thr Thr Thr Thr Glu Gln Pro Lys Pro Met Val Gln Thr Lys Gly 
945                 950                 955                 960 


Arg Pro His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser His His Ser 
                965                 970                 975     


Gln Leu Met Phe Pro Ala Leu Ser Thr Pro Ser Ser Ser Thr Pro Ser 
            980                 985                 990         


Val Pro Ala Gly Thr Ala Thr Asp  Val Ser Lys His Arg  Leu Gln Gly 
        995                 1000                 1005             


Phe Ile  Pro Cys Arg Ile Pro  Ser Ala Ser Pro Gln  Thr Gln Arg 
    1010                 1015                 1020             


Lys Phe  Ser Leu Gln Phe His  Arg Asn Cys Pro Glu  Asn Lys Asp 
    1025                 1030                 1035             


Ser Asp  Lys Leu Ser Pro Val  Phe Thr Gln Ser Arg  Pro Leu Pro 
    1040                 1045                 1050             


Ser Ser  Asn Ile His Arg Pro  Lys Pro Ser Arg Pro  Thr Pro Gly 
    1055                 1060                 1065             


Asn Thr  Ser Lys Gln Gly Asp  Pro Ser Lys Asn Ser  Met Thr Leu 
    1070                 1075                 1080             


Asp Leu  Asn Ser Ser Ser Lys  Cys Asp Asp Ser Phe  Gly Cys Ser 
    1085                 1090                 1095             


Ser Asn  Ser Ser Asn Ala Val  Ile Pro Ser Asp Glu  Thr Val Phe 
    1100                 1105                 1110             


Thr Pro  Val Glu Glu Lys Cys  Arg Leu Asp Val Asn  Thr Glu Leu 
    1115                 1120                 1125             


Asn Ser  Ser Ile Glu Asp Leu  Leu Glu Ala Ser Met  Pro Ser Ser 
    1130                 1135                 1140             


Asp Thr  Thr Val Thr Phe Lys  Ser Glu Val Ala Val  Leu Ser Pro 
    1145                 1150                 1155             


Glu Lys  Ala Glu Asn Asp Asp  Thr Tyr Lys Asp Asp  Val Asn His 
    1160                 1165                 1170             


Asn Gln  Lys Cys Lys Glu Lys  Met Glu Ala Glu Glu  Glu Glu Ala 
    1175                 1180                 1185             


Leu Ala  Ile Ala Met Ala Met  Ser Ala Ser Gln Asp  Ala Leu Pro 
    1190                 1195                 1200             


Ile Val  Pro Gln Leu Gln Val  Glu Asn Gly Glu Asp  Ile Ile Ile 
    1205                 1210                 1215             


Ile Gln  Gln Asp Thr Pro Glu  Thr Leu Pro Gly His  Thr Lys Ala 
    1220                 1225                 1230             


Lys Gln  Pro Tyr Arg Glu Asp  Thr Glu Trp Leu Lys  Gly Gln Gln 
    1235                 1240                 1245             


Ile Gly  Leu Gly Ala Phe Ser  Ser Cys Tyr Gln Ala  Gln Asp Val 
    1250                 1255                 1260             


Gly Thr  Gly Thr Leu Met Ala  Val Lys Gln Val Thr  Tyr Val Arg 
    1265                 1270                 1275             


Asn Thr  Ser Ser Glu Gln Glu  Glu Val Val Glu Ala  Leu Arg Glu 
    1280                 1285                 1290             


Glu Ile  Arg Met Met Ser His  Leu Asn His Pro Asn  Ile Ile Arg 
    1295                 1300                 1305             


Met Leu  Gly Ala Thr Cys Glu  Lys Ser Asn Tyr Asn  Leu Phe Ile 
    1310                 1315                 1320             


Glu Trp  Met Ala Gly Gly Ser  Val Ala His Leu Leu  Ser Lys Tyr 
    1325                 1330                 1335             


Gly Ala  Phe Lys Glu Ser Val  Val Ile Asn Tyr Thr  Glu Gln Leu 
    1340                 1345                 1350             


Leu Arg  Gly Leu Ser Tyr Leu  His Glu Asn Gln Ile  Ile His Arg 
    1355                 1360                 1365             


Asp Val  Lys Gly Ala Asn Leu  Leu Ile Asp Ser Thr  Gly Gln Arg 
    1370                 1375                 1380             


Leu Arg  Ile Ala Asp Phe Gly  Ala Ala Ala Arg Leu  Ala Ser Lys 
    1385                 1390                 1395             


Gly Thr  Gly Ala Gly Glu Phe  Gln Gly Gln Leu Leu  Gly Thr Ile 
    1400                 1405                 1410             


Ala Phe  Met Ala Pro Glu Val  Leu Arg Gly Gln Gln  Tyr Gly Arg 
    1415                 1420                 1425             


Ser Cys  Asp Val Trp Ser Val  Gly Cys Ala Ile Ile  Glu Met Ala 
    1430                 1435                 1440             


Cys Ala  Lys Pro Pro Trp Asn  Ala Glu Lys His Ser  Asn His Leu 
    1445                 1450                 1455             


Ala Leu  Ile Phe Lys Ile Ala  Ser Ala Thr Thr Ala  Pro Ser Ile 
    1460                 1465                 1470             


Pro Ser  His Leu Ser Pro Gly  Leu Arg Asp Val Ala  Leu Arg Cys 
    1475                 1480                 1485             


Leu Glu  Leu Gln Pro Gln Asp  Arg Pro Pro Ser Arg  Glu Leu Leu 
    1490                 1495                 1500             


Lys His  Pro Val Phe Arg Thr  Thr Trp 
    1505                 1510         


<210> 7051
<211> 757
<212> PRT
<213> Homo sapiens

<400> 7051
Ala Asp Gly Gly Asp Ser Gln Ala Phe Arg Cys Thr Ser Cys Gly His 
1               5                   10                  15      


Ala Gly Thr Thr Pro Ala Pro Arg Glu Ala Leu Ser Pro Ala Asp Ala 
            20                  25                  30          


His Val Gly Arg Gly Phe Ala Glu Arg Glu Pro Ile Pro Ala Gln Gly 
        35                  40                  45              


Leu Leu Val Leu Ala Val Leu Ser Asp Gly Ala Gly Asp His Ile Arg 
    50                  55                  60                  


Gln Arg Leu Leu Pro Pro Leu Leu Gln Ile Val Cys Lys Gly Leu Glu 
65                  70                  75                  80  


Asp Pro Ser Gln Val Val Arg Asn Ala Ala Leu Phe Ala Leu Gly Gln 
                85                  90                  95      


Phe Ser Glu Asn Leu Gln Pro His Ile Ser Ser Tyr Ser Arg Glu Val 
            100                 105                 110         


Met Pro Leu Leu Leu Ala Tyr Leu Lys Ser Val Pro Leu Gly His Thr 
        115                 120                 125             


His His Leu Ala Lys Ala Cys Tyr Ala Leu Glu Asn Phe Val Glu Asn 
    130                 135                 140                 


Leu Gly Pro Lys Val Gln Pro Tyr Leu Pro Glu Leu Met Glu Cys Met 
145                 150                 155                 160 


Leu Gln Leu Leu Arg Asn Pro Ser Ser Pro Arg Ala Lys Glu Leu Ala 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Ile Ala Thr Ala Ala Gln Ala Ser Leu Leu 
            180                 185                 190         


Pro Tyr Phe Pro Ala Ile Met Glu His Leu Arg Glu Phe Leu Leu Thr 
        195                 200                 205             


Gly Arg Glu Asp Leu Gln Pro Val Gln Ile Gln Ser Leu Glu Thr Leu 
    210                 215                 220                 


Gly Val Leu Ala Arg Ala Val Gly Glu Pro Met Arg Pro Leu Ala Glu 
225                 230                 235                 240 


Glu Cys Cys Gln Leu Gly Leu Gly Leu Cys Asp Gln Val Asp Asp Pro 
                245                 250                 255     


Asp Leu Arg Arg Cys Thr Tyr Ser Leu Phe Ala Ala Leu Ser Gly Leu 
            260                 265                 270         


Met Gly Glu Gly Leu Ala Pro His Leu Glu Gln Ile Thr Thr Leu Met 
        275                 280                 285             


Leu Leu Ser Leu Arg Ser Thr Glu Gly Ile Val Pro Gln Tyr Asp Gly 
    290                 295                 300                 


Ser Ser Ser Phe Leu Leu Phe Asp Asp Glu Ser Asp Gly Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Leu Met Asp Glu Asp Val Glu Glu Glu Asp Asp Ser Glu Ile 
                325                 330                 335     


Ser Gly Tyr Ser Val Glu Asn Ala Phe Phe Asp Glu Lys Glu Asp Thr 
            340                 345                 350         


Cys Ala Ala Val Gly Glu Ile Ser Val Asn Thr Ser Val Ala Phe Leu 
        355                 360                 365             


Pro Tyr Met Glu Ser Val Phe Glu Glu Val Phe Lys Leu Leu Glu Cys 
    370                 375                 380                 


Pro His Leu Asn Val Arg Lys Ala Ala His Glu Ala Leu Gly Gln Phe 
385                 390                 395                 400 


Cys Cys Ala Leu His Lys Ala Cys Gln Ser Cys Pro Ser Glu Pro Asn 
                405                 410                 415     


Thr Ala Ala Leu Gln Ala Ala Leu Ala Arg Val Val Pro Ser Tyr Met 
            420                 425                 430         


Gln Ala Val Asn Arg Glu Arg Glu Arg Gln Val Val Met Ala Val Leu 
        435                 440                 445             


Glu Ala Leu Thr Gly Val Leu Arg Ser Cys Gly Thr Leu Thr Leu Lys 
    450                 455                 460                 


Pro Pro Gly Arg Leu Ala Glu Leu Cys Gly Val Leu Lys Ala Val Leu 
465                 470                 475                 480 


Gln Arg Lys Thr Ala Cys Gln Asp Thr Asp Glu Glu Glu Glu Glu Glu 
                485                 490                 495     


Asp Asp Asp Gln Ala Glu Tyr Asp Ala Met Leu Leu Glu His Ala Gly 
            500                 505                 510         


Glu Ala Ile Pro Ala Leu Ala Ala Ala Ala Gly Gly Asp Ser Phe Ala 
        515                 520                 525             


Pro Phe Phe Ala Gly Phe Leu Pro Leu Leu Val Cys Lys Thr Lys Gln 
    530                 535                 540                 


Gly Cys Thr Val Ala Glu Lys Ser Phe Ala Val Gly Thr Leu Ala Glu 
545                 550                 555                 560 


Thr Ile Gln Gly Leu Gly Ala Ala Ser Ala Gln Phe Val Ser Arg Leu 
                565                 570                 575     


Leu Pro Val Leu Leu Ser Thr Ala Gln Glu Ala Asp Pro Glu Val Arg 
            580                 585                 590         


Ser Asn Ala Ile Phe Gly Met Gly Val Leu Ala Glu His Gly Gly His 
        595                 600                 605             


Pro Ala Gln Glu His Phe Pro Lys Leu Leu Gly Leu Leu Phe Pro Leu 
    610                 615                 620                 


Leu Ala Arg Glu Arg His Asp Arg Val Arg Asp Asn Ile Cys Gly Ala 
625                 630                 635                 640 


Leu Ala Arg Leu Leu Met Ala Ser Pro Thr Arg Lys Pro Glu Pro Gln 
                645                 650                 655     


Val Leu Ala Ala Leu Leu His Ala Leu Pro Leu Lys Glu Asp Leu Glu 
            660                 665                 670         


Glu Trp Val Thr Ile Gly Arg Leu Phe Ser Phe Leu Tyr Gln Ser Ser 
        675                 680                 685             


Pro Asp Gln Val Ile Asp Val Ala Pro Glu Leu Leu Arg Ile Cys Ser 
    690                 695                 700                 


Leu Ile Leu Ala Asp Asn Lys Ile Pro Pro Asp Thr Lys Ala Ala Leu 
705                 710                 715                 720 


Leu Leu Leu Leu Thr Phe Leu Ala Lys Gln His Thr Asp Ser Phe Gln 
                725                 730                 735     


Ala Ala Leu Gly Ser Leu Pro Val Asp Lys Ala Gln Glu Leu Gln Ala 
            740                 745                 750         


Val Leu Gly Leu Ser 
        755         


<210> 7052
<211> 603
<212> PRT
<213> Homo sapiens

<400> 7052
Met Gly Val Ile Pro Glu Gly Pro Leu Trp Val Ser Gly Ser Asp Asp 
1               5                   10                  15      


Asn Leu Ser Gly Thr Ser Gly Met Glu Val Asp Asp Arg Val Ser Ala 
            20                  25                  30          


Leu Glu Gln Arg Leu Gln Leu Gln Glu Asp Glu Leu Ala Val Leu Lys 
        35                  40                  45              


Ala Ala Leu Ala Asp Ala Leu Arg Arg Leu Arg Ala Cys Glu Glu Gln 
    50                  55                  60                  


Gly Ala Ala Leu Arg Ala Arg Gly Thr Pro Lys Gly Arg Ala Pro Pro 
65                  70                  75                  80  


Arg Leu Gly Thr Thr Ala Ser Val Cys Gln Leu Leu Lys Gly Leu Pro 
                85                  90                  95      


Thr Arg Thr Pro Leu Asn Gly Ser Gly Pro Pro Arg Arg Val Gly Gly 
            100                 105                 110         


Tyr Ala Thr Ser Pro Ser Ser Pro Lys Lys Glu Ala Thr Ser Gly Arg 
        115                 120                 125             


Ser Ser Val Arg Arg Tyr Leu Ser Pro Glu Arg Leu Ala Ser Val Arg 
    130                 135                 140                 


Arg Glu Asp Pro Arg Ser Arg Thr Thr Ser Ser Ser Ser Asn Cys Ser 
145                 150                 155                 160 


Ala Lys Lys Glu Gly Lys Thr Lys Glu Val Ile Phe Ser Val Glu Asp 
                165                 170                 175     


Gly Ser Val Lys Met Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile 
            180                 185                 190         


Pro Asp Glu Leu Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu 
        195                 200                 205             


Pro Ser Cys Arg Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg 
    210                 215                 220                 


Asp Cys Arg Ala Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr 
225                 230                 235                 240 


Phe Val Ala Ser Val Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln 
                245                 250                 255     


Arg His Tyr Leu Gly His Asn Asp Asp Ile Lys Cys Leu Ala Ile His 
            260                 265                 270         


Pro Asp Met Val Thr Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys 
        275                 280                 285             


Glu Gly Lys Pro Leu Pro Pro His Val Arg Ile Trp Asp Ser Val Ser 
    290                 295                 300                 


Leu Ser Thr Leu His Val Leu Gly Leu Gly Val Phe Asp Arg Ala Val 
305                 310                 315                 320 


Cys Cys Val Gly Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu Cys Ala 
                325                 330                 335     


Val Asp Glu Ser Asn Asp His Met Leu Ser Val Trp Asp Trp Ala Lys 
            340                 345                 350         


Glu Thr Lys Val Val Asp Val Lys Cys Ser Asn Glu Ala Val Leu Val 
        355                 360                 365             


Ala Thr Phe His Pro Thr Asp Pro Thr Val Leu Ile Thr Cys Gly Lys 
    370                 375                 380                 


Ser His Ile Tyr Phe Trp Thr Leu Glu Gly Gly Ser Leu Ser Lys Arg 
385                 390                 395                 400 


Gln Gly Leu Phe Glu Lys His Glu Lys Pro Lys Tyr Val Leu Cys Val 
                405                 410                 415     


Thr Phe Leu Glu Gly Gly Asp Val Val Thr Gly Asp Ser Gly Gly Asn 
            420                 425                 430         


Leu Tyr Val Trp Gly Lys Gly Gly Asn Arg Ile Thr Gln Ala Val Leu 
        435                 440                 445             


Gly Ala His Asp Gly Gly Val Phe Gly Leu Cys Ala Leu Arg Asp Gly 
    450                 455                 460                 


Thr Leu Val Ser Gly Gly Gly Arg Asp Arg Arg Val Val Leu Trp Gly 
465                 470                 475                 480 


Ser Asp Tyr Ser Lys Leu Gln Glu Val Glu Val Pro Glu Asp Phe Gly 
                485                 490                 495     


Pro Val Arg Thr Val Ala Glu Gly His Gly Asp Thr Leu Tyr Val Gly 
            500                 505                 510         


Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly Phe Ser 
        515                 520                 525             


Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala Thr His 
    530                 535                 540                 


Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu Val His 
545                 550                 555                 560 


Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile Ile Glu 
                565                 570                 575     


Val Glu Ser Arg Ser Val Thr Gln Ala Gly Gly Gln Trp His Asp Leu 
            580                 585                 590         


Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys 
        595                 600             


<210> 7053
<211> 331
<212> PRT
<213> Homo sapiens

<400> 7053
Met Ala Glu Gly Gly Gly Pro Glu Pro Gly Glu Gln Glu Arg Arg Ser 
1               5                   10                  15      


Ser Gly Pro Arg Pro Pro Ser Ala Arg Asp Leu Gln Leu Ala Leu Ala 
            20                  25                  30          


Glu Leu Tyr Glu Asp Glu Val Lys Cys Lys Ser Ser Lys Ser Asn Arg 
        35                  40                  45              


Pro Lys Ala Thr Val Phe Lys Ser Pro Arg Thr Pro Pro Gln Arg Phe 
    50                  55                  60                  


Tyr Ser Ser Glu His Glu Tyr Ser Gly Leu Asn Ile Val Arg Pro Ser 
65                  70                  75                  80  


Thr Gly Lys Ile Val Asn Glu Leu Phe Lys Glu Ala Arg Glu His Gly 
                85                  90                  95      


Ala Val Pro Leu Asn Glu Ala Thr Arg Ala Ser Gly Asp Asp Lys Ser 
            100                 105                 110         


Lys Ser Phe Thr Gly Gly Gly Tyr Arg Leu Gly Ser Ser Phe Cys Lys 
        115                 120                 125             


Arg Ser Glu Tyr Ile Tyr Gly Glu Asn Gln Leu Gln Asp Val Gln Ile 
    130                 135                 140                 


Leu Leu Lys Leu Trp Ser Asn Gly Phe Ser Leu Asp Asp Gly Glu Leu 
145                 150                 155                 160 


Arg Pro Tyr Asn Glu Pro Thr Asn Ala Gln Phe Leu Glu Ser Val Lys 
                165                 170                 175     


Arg Gly Glu Ile Pro Leu Glu Leu Gln Arg Leu Val His Gly Gly Gln 
            180                 185                 190         


Val Asn Leu Asp Met Glu Asp His Gln Asp Gln Glu Tyr Ile Lys Pro 
        195                 200                 205             


Arg Leu Arg Phe Lys Ala Phe Ser Gly Glu Gly Gln Lys Leu Gly Ser 
    210                 215                 220                 


Leu Thr Pro Glu Ile Val Ser Thr Pro Ser Ser Pro Glu Glu Glu Asp 
225                 230                 235                 240 


Lys Ser Ile Leu Asn Ala Val Val Leu Ile Asp Asp Ser Val Pro Thr 
                245                 250                 255     


Thr Lys Ile Gln Ile Arg Leu Ala Asp Gly Ser Arg Leu Ile Gln Arg 
            260                 265                 270         


Phe Asn Ser Thr His Arg Ile Leu Asp Val Arg Asn Phe Ile Val Gln 
        275                 280                 285             


Ser Arg Pro Glu Phe Ala Ala Leu Asp Phe Ile Leu Val Thr Ser Phe 
    290                 295                 300                 


Pro Asn Lys Glu Leu Thr Asp Glu Ser Leu Thr Leu Leu Glu Ala Asp 
305                 310                 315                 320 


Ile Leu Asn Thr Val Leu Leu Gln Gln Leu Lys 
                325                 330     


<210> 7054
<211> 687
<212> PRT
<213> Homo sapiens

<400> 7054
Met Asp Gly Gly Ala Leu Thr Asp Thr Ser Leu Thr Asp Ser Tyr Phe 
1               5                   10                  15      


Ser Thr Ser Phe Ile Gly Val Asn Gly Phe Gly Ser Pro Val Glu Thr 
            20                  25                  30          


Lys Tyr Pro Leu Met Gln Arg Met Thr Asn Ser Ser Ser Ser Pro Ser 
        35                  40                  45              


Leu Leu Asn Asp Ser Ala Lys Pro Tyr Ser Ala His Asp Pro Leu Thr 
    50                  55                  60                  


Ser Pro Ala Ser Ser Leu Phe Asn Asp Phe Gly Ala Leu Asn Ile Ser 
65                  70                  75                  80  


Gln Arg Arg Lys Thr Pro Asn Pro Thr Ala Ser Glu Phe Ile Pro Lys 
                85                  90                  95      


Gly Gly Ser Thr Ser Arg Leu Ser Asn Val Ser Gln Ser Asn Met Ser 
            100                 105                 110         


Ala Phe Ser Gln Val Phe Ser His Pro Ser Met Gly Ser Pro Ala Thr 
        115                 120                 125             


Ala Gly Leu Ala Pro Gly Met Ser Leu Ser Ala Gly Ser Ser Pro Leu 
    130                 135                 140                 


His Ser Pro Lys Ile Thr Pro His Thr Ser Pro Ala Pro Arg Arg Arg 
145                 150                 155                 160 


Ser His Thr Pro Asn Pro Ala Ser Tyr Met Val Pro Ser Ser Ala Ser 
                165                 170                 175     


Thr Ser Val Asn Asn Pro Val Ser Gln Thr Pro Ser Ser Gly Gln Val 
            180                 185                 190         


Ile Gln Lys Glu Thr Val Gly Gly Thr Thr Tyr Phe Tyr Thr Asp Thr 
        195                 200                 205             


Thr Pro Ala Pro Leu Thr Gly Met Val Phe Pro Asn Tyr His Ile Tyr 
    210                 215                 220                 


Pro Pro Thr Ala Pro His Val Ala Tyr Met Gln Pro Lys Ala Asn Ala 
225                 230                 235                 240 


Pro Ser Phe Phe Met Ala Asp Glu Leu Arg Gln Glu Leu Ile Asn Arg 
                245                 250                 255     


His Leu Ile Thr Met Ala Gln Ile Asp Gln Ala Asp Met Pro Ala Val 
            260                 265                 270         


Pro Thr Glu Val Asp Ser Tyr His Ser Leu Phe Pro Leu Glu Pro Leu 
        275                 280                 285             


Pro Pro Pro Asn Arg Ile Gln Lys Ser Ser Asn Phe Gly Tyr Ile Thr 
    290                 295                 300                 


Ser Cys Tyr Lys Ala Val Asn Ser Lys Asp Asp Leu Pro Tyr Cys Leu 
305                 310                 315                 320 


Arg Arg Ile His Gly Phe Arg Leu Val Asn Thr Lys Cys Met Val Leu 
                325                 330                 335     


Val Asp Met Trp Lys Lys Ile Gln His Ser Asn Ile Val Thr Leu Arg 
            340                 345                 350         


Glu Val Phe Thr Thr Lys Ala Phe Ala Glu Pro Ser Leu Val Phe Ala 
        355                 360                 365             


Tyr Asp Phe His Ala Gly Gly Glu Thr Met Met Ser Arg His Phe Asn 
    370                 375                 380                 


Asp Pro Asn Ala Asp Ala Tyr Phe Thr Lys Arg Lys Trp Gly Gln His 
385                 390                 395                 400 


Glu Gly Pro Leu Pro Arg Gln His Ala Gly Leu Leu Pro Glu Ser Leu 
                405                 410                 415     


Ile Trp Ala Tyr Ile Val Gln Leu Ser Ser Ala Leu Arg Thr Ile His 
            420                 425                 430         


Thr Ala Gly Leu Ala Cys Arg Val Met Asp Pro Thr Lys Ile Leu Ile 
        435                 440                 445             


Thr Gly Lys Thr Arg Leu Arg Val Asn Cys Val Gly Val Phe Asp Val 
    450                 455                 460                 


Leu Thr Phe Asp Asn Ser Gln Asn Asn Asn Pro Leu Ala Leu Met Ala 
465                 470                 475                 480 


Gln Tyr Gln Gln Ala Asp Leu Ile Ser Leu Gly Lys Val Val Leu Ala 
                485                 490                 495     


Leu Ala Cys Asn Ser Leu Ala Gly Ile Gln Arg Glu Asn Leu Gln Lys 
            500                 505                 510         


Ala Met Glu Leu Val Thr Ile Asn Tyr Ser Ser Asp Leu Lys Asn Leu 
        515                 520                 525             


Ile Leu Tyr Leu Leu Thr Asp Gln Asn Arg Met Arg Ser Val Asn Asp 
    530                 535                 540                 


Ile Met Pro Met Ile Gly Ala Arg Phe Tyr Thr Gln Leu Asp Ala Ala 
545                 550                 555                 560 


Gln Met Arg Asn Asp Val Ile Glu Glu Asp Leu Ala Lys Glu Val Gln 
                565                 570                 575     


Asn Gly Arg Leu Phe Arg Leu Leu Ala Lys Leu Gly Thr Ile Asn Glu 
            580                 585                 590         


Arg Pro Glu Phe Gln Lys Asp Pro Thr Trp Ser Glu Thr Gly Asp Arg 
        595                 600                 605             


Tyr Leu Leu Lys Leu Phe Arg Asp His Leu Phe His Gln Val Thr Glu 
    610                 615                 620                 


Ala Gly Ala Pro Trp Ile Asp Leu Ser His Ile Ile Ser Cys Leu Asn 
625                 630                 635                 640 


Lys Leu Asp Ala Gly Val Pro Glu Lys Ile Ser Leu Ile Ser Arg Asp 
                645                 650                 655     


Glu Lys Ser Val Leu Val Val Thr Tyr Ser Asp Leu Lys Arg Cys Phe 
            660                 665                 670         


Glu Asn Thr Phe Gln Glu Leu Ile Ala Ala Ala Asn Gly Gln Leu 
        675                 680                 685         


<210> 7055
<211> 2316
<212> PRT
<213> Homo sapiens

<400> 7055
Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu 
1               5                   10                  15      


Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser 
            20                  25                  30          


Pro Leu Gln Asp Leu Arg Gly Gly Asn Glu Arg Val Gln Glu Ser Asn 
        35                  40                  45              


Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr 
    50                  55                  60                  


Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser 
65                  70                  75                  80  


Glu Met Glu Glu Thr Glu Thr Gly Glu Asn Leu Leu Leu Ile Gln Asn 
                85                  90                  95      


Lys Lys Leu Glu Asp Asn Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu 
            100                 105                 110         


Leu Ser Ala Pro Ile His Thr Gln Met Gln Gln Lys Glu Phe Ser Ile 
        115                 120                 125             


Ile Glu His Thr Arg Glu Arg Lys His Ala Asn Asp Gln Thr Val Ile 
    130                 135                 140                 


Phe Ser Asp Glu Asn Gln Met Asp Leu Thr Ser Ser His Thr Val Met 
145                 150                 155                 160 


Ile Thr Lys Gly Leu Leu Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys 
                165                 170                 175     


Ile Asp Thr Thr Ser Phe Leu Ala Asn Leu Lys Leu His Thr Glu Asp 
            180                 185                 190         


Ser Arg Met Lys Lys Glu Val Asn Phe Ser Val Asp Gln Asn Thr Ser 
        195                 200                 205             


Ser Glu Asn Lys Ile Asp Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr 
    210                 215                 220                 


Gly Lys Cys Ser Ala Phe Pro Asp Val Pro Asp Lys Glu Asn Phe Glu 
225                 230                 235                 240 


Ile Pro Ile Tyr Ser Lys Glu Pro Asn Ser Ala Ser Ser Thr His Gln 
                245                 250                 255     


Met His Val Ser Leu Lys Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg 
            260                 265                 270         


Leu Phe Arg Glu Lys Asp Asp Gly Met Asn Phe Thr Gln Cys His Thr 
        275                 280                 285             


Ala Asn Ile Gln Thr Leu Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg 
    290                 295                 300                 


Glu Ser Lys Gly Asn Asp Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp 
305                 310                 315                 320 


Leu Thr Phe Asn His Thr Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe 
                325                 330                 335     


Ser Glu Ile Glu Asn Gln Thr Gln Asn Ala Met Asp Val Thr Thr Gly 
            340                 345                 350         


Tyr Gly Thr Lys Ala Ser Gly Asn Lys Thr Val Phe Lys Ser Lys Gln 
        355                 360                 365             


Asn Thr Ala Phe Gln Asp Leu Ser Ile Asn Ser Ala Asp Lys Ile His 
    370                 375                 380                 


Ile Thr Arg Ser His Ile Met Gly Ala Glu Thr His Ile Val Ser Gln 
385                 390                 395                 400 


Thr Cys Asn Gln Asp Ala Arg Ile Leu Ala Met Thr Pro Glu Ser Ile 
                405                 410                 415     


Tyr Ser Asn Pro Ser Ile Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser 
            420                 425                 430         


Cys Asn Asp Ala Met Glu Met Thr Lys Cys Leu Ser Asn Met Arg Glu 
        435                 440                 445             


Glu Lys Asn Leu Leu Lys His Asp Ser Asn Tyr Ala Lys Met Tyr Cys 
    450                 455                 460                 


Asn Pro Asp Ala Met Ser Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly 
465                 470                 475                 480 


Glu Glu Asn Met Asp Ile Thr Lys Ser His Thr Val Ala Ile Asp Asn 
                485                 490                 495     


Gln Ile Phe Lys Gln Asp Gln Ser Asn Val Gln Ile Ala Ala Ala Pro 
            500                 505                 510         


Thr Pro Glu Lys Glu Met Met Leu Gln Asn Leu Met Thr Thr Ser Glu 
        515                 520                 525             


Asp Gly Lys Met Asn Val Asn Cys Asn Ser Val Pro His Val Ser Lys 
    530                 535                 540                 


Glu Arg Ile Gln Gln Ser Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr 
545                 550                 555                 560 


Asp Arg Lys Thr Glu Leu Leu Ser Gly Glu Asn Met Asp Leu Thr Glu 
                565                 570                 575     


Ser His Thr Ser Asn Leu Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn 
            580                 585                 590         


Leu Ala Pro Glu Ser Thr Ser Glu Ser His Ser Gln Ser Lys Ser Ser 
        595                 600                 605             


Ser Asp Glu Cys Glu Glu Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln 
    610                 615                 620                 


Arg Ser Asp Ile Ile Ala Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys 
625                 630                 635                 640 


Asp Lys Asp Trp Val Leu Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser 
                645                 650                 655     


Pro Gln Ser Ala Asp Cys Asn Gln Glu Ile Ala Thr Ser His Asn Ile 
            660                 665                 670         


Val Tyr Cys Gly Gly Val Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr 
        675                 680                 685             


Val Ser Trp Glu Gln Ser Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser 
    690                 695                 700                 


Ser Gly Gln Phe Ser Met Lys Asn His Asp Thr Ala Ile Ser Ser His 
705                 710                 715                 720 


Thr Val Lys Ser Val Leu Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu 
                725                 730                 735     


Arg Lys Ser Leu Ser Asn Pro Thr Pro Asp Tyr Cys His Asp Lys Met 
            740                 745                 750         


Ile Ile Cys Ser Glu Glu Glu Gln Asn Met Asp Leu Thr Lys Ser His 
        755                 760                 765             


Thr Val Val Ile Gly Phe Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys 
    770                 775                 780                 


Thr Asn Leu Glu His Thr Thr Gly Gln Leu Thr Thr Met Asn Arg Gln 
785                 790                 795                 800 


Ile Ala Val Lys Val Glu Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser 
                805                 810                 815     


Gly Val Leu Lys Ser Asn Cys Ile Met Asp Val Leu Glu Asp Glu Ser 
            820                 825                 830         


Val Gln Lys Pro Lys Phe Pro Lys Glu Lys Gln Asn Val Lys Ile Trp 
        835                 840                 845             


Gly Arg Lys Ser Val Gly Gly Pro Lys Ile Asp Lys Thr Ile Val Phe 
    850                 855                 860                 


Ser Glu Asp Asp Lys Asn Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile 
865                 870                 875                 880 


Glu Ile Asn His Arg Pro Leu Leu Glu Lys Arg Asp Cys His Leu Val 
                885                 890                 895     


Pro Leu Ala Gly Thr Ser Glu Thr Ile Leu Tyr Thr Cys Arg Gln Asp 
            900                 905                 910         


Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu Glu Cys Lys Thr 
        915                 920                 925             


Val Ser Pro Asp Glu Ile Thr Thr Arg Pro Met Asp Lys Thr Val Val 
    930                 935                 940                 


Phe Val Asp Asn His Val Glu Leu Glu Met Thr Glu Ser His Thr Val 
945                 950                 955                 960 


Phe Ile Asp Tyr Gln Glu Lys Glu Arg Thr Asp Arg Pro Asn Phe Glu 
                965                 970                 975     


Leu Ser Gln Arg Lys Ser Leu Gly Thr Pro Thr Val Ile Cys Thr Pro 
            980                 985                 990         


Thr Glu Glu Ser Val Phe Phe Pro  Gly Asn Gly Glu Ser  Asp Arg Leu 
        995                 1000                 1005             


Val Ala  Asn Asp Ser Gln Leu  Thr Pro Leu Glu Glu  Trp Ser Asn 
    1010                 1015                 1020             


Asn Arg  Gly Pro Val Glu Val  Ala Asp Asn Met Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ser Ala  Thr Cys Lys Asn Ile  Lys Asp Val Gln Ser  Pro Gly Phe 
    1040                 1045                 1050             


Leu Asn  Glu Pro Leu Ser Ser  Lys Ser Gln Arg Arg  Lys Ser Leu 
    1055                 1060                 1065             


Lys Leu  Lys Asn Asp Lys Thr  Ile Val Phe Ser Glu  Asn His Lys 
    1070                 1075                 1080             


Asn Asp  Met Asp Ile Thr Gln  Ser Cys Met Val Glu  Ile Asp Asn 
    1085                 1090                 1095             


Glu Ser  Ala Leu Glu Asp Lys  Glu Asp Phe His Leu  Ala Gly Ala 
    1100                 1105                 1110             


Ser Lys  Thr Ile Leu Tyr Ser  Cys Gly Gln Asp Asp  Met Glu Ile 
    1115                 1120                 1125             


Thr Arg  Ser His Thr Thr Ala  Leu Glu Cys Lys Thr  Leu Leu Pro 
    1130                 1135                 1140             


Asn Glu  Ile Ala Ile Arg Pro  Met Asp Lys Thr Val  Leu Phe Thr 
    1145                 1150                 1155             


Asp Asn  Tyr Ser Asp Leu Glu  Val Thr Asp Ser His  Thr Val Phe 
    1160                 1165                 1170             


Ile Asp  Cys Gln Ala Thr Glu  Lys Ile Leu Glu Glu  Asn Pro Lys 
    1175                 1180                 1185             


Phe Gly  Ile Gly Lys Gly Lys  Asn Leu Gly Val Ser  Phe Pro Lys 
    1190                 1195                 1200             


Asp Asn  Ser Cys Val Gln Glu  Ile Ala Glu Lys Gln  Ala Leu Ala 
    1205                 1210                 1215             


Val Gly  Asn Lys Ile Val Leu  His Thr Glu Gln Lys  Gln Gln Leu 
    1220                 1225                 1230             


Phe Ala  Ala Thr Asn Arg Thr  Thr Asn Glu Ile Ile  Lys Phe His 
    1235                 1240                 1245             


Ser Ala  Ala Met Asp Glu Lys  Val Ile Gly Lys Val  Val Asp Gln 
    1250                 1255                 1260             


Ala Cys  Thr Leu Glu Lys Ala  Gln Val Glu Ser Cys  Gln Leu Asn 
    1265                 1270                 1275             


Asn Arg  Asp Arg Arg Asn Val  Asp Phe Thr Ser Ser  His Ala Thr 
    1280                 1285                 1290             


Ala Val  Cys Gly Ser Ser Asp  Asn Tyr Ser Cys Leu  Pro Asn Val 
    1295                 1300                 1305             


Ile Ser  Cys Thr Asp Asn Leu  Glu Gly Ser Ala Met  Leu Leu Cys 
    1310                 1315                 1320             


Asp Lys  Asp Glu Glu Lys Ala  Asn Tyr Cys Pro Val  Gln Asn Asp 
    1325                 1330                 1335             


Leu Ala  Tyr Ala Asn Asp Phe  Ala Ser Glu Tyr Tyr  Leu Glu Ser 
    1340                 1345                 1350             


Glu Gly  Gln Pro Leu Ser Ala  Pro Cys Pro Leu Leu  Glu Lys Glu 
    1355                 1360                 1365             


Glu Val  Ile Gln Thr Ser Thr  Lys Gly Gln Leu Asp  Cys Val Ile 
    1370                 1375                 1380             


Thr Leu  His Lys Asp Gln Asp  Leu Ile Lys Asp Pro  Arg Asn Leu 
    1385                 1390                 1395             


Leu Ala  Asn Gln Thr Leu Val  Tyr Ser Gln Asp Leu  Gly Glu Met 
    1400                 1405                 1410             


Thr Lys  Leu Asn Ser Lys Arg  Val Ser Phe Lys Leu  Pro Lys Asp 
    1415                 1420                 1425             


Gln Met  Lys Val Tyr Val Asp  Asp Ile Tyr Val Ile  Pro Gln Pro 
    1430                 1435                 1440             


His Phe  Ser Thr Asp Gln Pro  Pro Leu Pro Lys Lys  Gly Gln Ser 
    1445                 1450                 1455             


Ser Ile  Asn Lys Glu Glu Val  Ile Leu Ser Lys Ala  Gly Asn Lys 
    1460                 1465                 1470             


Ser Leu  Asn Ile Ile Glu Asn  Ser Ser Ala Pro Ile  Cys Glu Asn 
    1475                 1480                 1485             


Lys Pro  Lys Ile Leu Asn Ser  Glu Glu Trp Phe Ala  Ala Ala Cys 
    1490                 1495                 1500             


Lys Lys  Glu Leu Lys Glu Asn  Ile Gln Thr Thr Asn  Tyr Asn Thr 
    1505                 1510                 1515             


Ala Leu  Asp Phe His Ser Asn  Ser Asp Val Thr Lys  Gln Val Ile 
    1520                 1525                 1530             


Gln Thr  His Val Asn Ala Gly  Glu Ala Pro Asp Pro  Val Ile Thr 
    1535                 1540                 1545             


Ser Asn  Val Pro Cys Phe His  Ser Ile Lys Pro Asn  Leu Asn Asn 
    1550                 1555                 1560             


Leu Asn  Gly Lys Thr Gly Glu  Phe Leu Ala Phe Gln  Thr Val His 
    1565                 1570                 1575             


Leu Pro  Pro Leu Pro Glu Gln  Leu Leu Glu Leu Gly  Asn Lys Ala 
    1580                 1585                 1590             


His Asn  Asp Met His Ile Val  Gln Ala Thr Glu Ile  His Asn Ile 
    1595                 1600                 1605             


Asn Ile  Ile Ser Ser Asn Ala  Lys Asp Ser Arg Asp  Glu Glu Asn 
    1610                 1615                 1620             


Lys Lys  Ser His Asn Gly Ala  Glu Thr Thr Ser Leu  Pro Pro Lys 
    1625                 1630                 1635             


Thr Val  Phe Lys Asp Lys Val  Arg Arg Cys Ser Leu  Gly Ile Phe 
    1640                 1645                 1650             


Leu Pro  Arg Leu Pro Asn Lys  Arg Asn Cys Ser Val  Thr Gly Ile 
    1655                 1660                 1665             


Asp Asp  Leu Glu Gln Ile Pro  Ala Asp Thr Thr Asp  Ile Asn His 
    1670                 1675                 1680             


Leu Glu  Thr Gln Pro Val Ser  Ser Lys Asp Ser Gly  Ile Gly Ser 
    1685                 1690                 1695             


Val Ala  Gly Lys Leu Asn Leu  Ser Pro Ser Gln Tyr  Ile Asn Glu 
    1700                 1705                 1710             


Glu Asn  Leu Pro Val Tyr Pro  Asp Glu Ile Asn Ser  Ser Asp Ser 
    1715                 1720                 1725             


Ile Asn  Ile Glu Thr Glu Glu  Lys Ala Leu Ile Glu  Thr Tyr Gln 
    1730                 1735                 1740             


Lys Glu  Ile Ser Pro Tyr Glu  Asn Lys Met Gly Lys  Thr Cys Asn 
    1745                 1750                 1755             


Ser Gln  Lys Arg Thr Trp Val  Gln Glu Glu Glu Asp  Ile His Lys 
    1760                 1765                 1770             


Glu Lys  Lys Ile Arg Lys Asn  Glu Ile Lys Phe Ser  Asp Thr Thr 
    1775                 1780                 1785             


Gln Asp  Arg Glu Ile Phe Asp  His His Thr Glu Glu  Asp Ile Asp 
    1790                 1795                 1800             


Lys Ser  Ala Asn Ser Val Leu  Ile Lys Asn Leu Ser  Arg Thr Pro 
    1805                 1810                 1815             


Ser Ser  Cys Ser Ser Ser Leu  Asp Ser Ile Lys Ala  Asp Gly Thr 
    1820                 1825                 1830             


Ser Leu  Asp Phe Ser Thr Tyr  Arg Ser Ser Gln Met  Glu Ser Gln 
    1835                 1840                 1845             


Phe Leu  Arg Asp Thr Ile Cys  Glu Glu Ser Leu Arg  Glu Lys Leu 
    1850                 1855                 1860             


Gln Asp  Gly Arg Ile Thr Ile  Arg Glu Phe Phe Ile  Leu Leu Gln 
    1865                 1870                 1875             


Val His  Ile Leu Ile Gln Lys  Pro Arg Gln Ser Asn  Leu Pro Gly 
    1880                 1885                 1890             


Asn Phe  Thr Val Asn Thr Pro  Pro Thr Pro Glu Asp  Leu Met Leu 
    1895                 1900                 1905             


Ser Gln  Tyr Val Tyr Arg Pro  Lys Ile Gln Ile Tyr  Arg Glu Asp 
    1910                 1915                 1920             


Cys Glu  Ala Arg Arg Gln Lys  Ile Glu Glu Leu Lys  Leu Ser Ala 
    1925                 1930                 1935             


Ser Asn  Gln Asp Lys Leu Leu  Val Asp Ile Asn Lys  Asn Leu Trp 
    1940                 1945                 1950             


Glu Lys  Met Arg His Cys Ser  Asp Lys Glu Leu Lys  Ala Phe Gly 
    1955                 1960                 1965             


Ile Tyr  Leu Asn Lys Ile Lys  Ser Cys Phe Thr Lys  Met Thr Lys 
    1970                 1975                 1980             


Val Phe  Thr His Gln Gly Lys  Val Ala Leu Tyr Gly  Lys Leu Val 
    1985                 1990                 1995             


Gln Ser  Ala Gln Asn Glu Arg  Glu Lys Leu Gln Ile  Lys Ile Asp 
    2000                 2005                 2010             


Glu Met  Asp Lys Ile Leu Lys  Lys Ile Asp Asn Cys  Leu Thr Glu 
    2015                 2020                 2025             


Met Glu  Thr Glu Thr Lys Asn  Leu Glu Asp Glu Glu  Lys Asn Asn 
    2030                 2035                 2040             


Pro Val  Glu Glu Trp Asp Ser  Glu Met Arg Ala Ala  Glu Lys Glu 
    2045                 2050                 2055             


Leu Glu  Gln Leu Lys Thr Glu  Glu Glu Glu Leu Gln  Arg Asn Leu 
    2060                 2065                 2070             


Leu Glu  Leu Glu Val Gln Lys  Glu Gln Thr Leu Ala  Gln Ile Asp 
    2075                 2080                 2085             


Phe Met  Gln Lys Gln Arg Asn  Arg Thr Glu Glu Leu  Leu Asp Gln 
    2090                 2095                 2100             


Leu Ser  Leu Ser Glu Trp Asp  Val Val Glu Trp Ser  Asp Asp Gln 
    2105                 2110                 2115             


Ala Val  Phe Thr Phe Val Tyr  Asp Thr Ile Gln Leu  Thr Ile Thr 
    2120                 2125                 2130             


Phe Glu  Glu Ser Val Val Gly  Phe Pro Phe Leu Asp  Lys Arg Tyr 
    2135                 2140                 2145             


Arg Lys  Ile Val Asp Val Asn  Phe Gln Ser Leu Leu  Asp Glu Asp 
    2150                 2155                 2160             


Gln Ala  Pro Pro Ser Ser Leu  Leu Val His Lys Leu  Ile Phe Gln 
    2165                 2170                 2175             


Tyr Val  Glu Glu Lys Glu Ser  Trp Lys Lys Thr Cys  Thr Thr Gln 
    2180                 2185                 2190             


His Gln  Leu Pro Lys Met Leu  Glu Glu Phe Ser Leu  Val Val His 
    2195                 2200                 2205             


His Cys  Arg Leu Leu Gly Glu  Glu Ile Glu Tyr Leu  Lys Arg Trp 
    2210                 2215                 2220             


Gly Pro  Asn Tyr Asn Leu Met  Asn Ile Asp Ile Asn  Asn Asn Glu 
    2225                 2230                 2235             


Leu Arg  Leu Leu Phe Ser Ser  Ser Ala Ala Phe Ala  Lys Phe Glu 
    2240                 2245                 2250             


Ile Thr  Leu Phe Leu Ser Ala  Tyr Tyr Pro Ser Val  Pro Leu Pro 
    2255                 2260                 2265             


Ser Thr  Ile Gln Asn His Val  Gly Asn Thr Ser Gln  Asp Asp Ile 
    2270                 2275                 2280             


Ala Thr  Ile Leu Ser Lys Val  Pro Leu Glu Asn Asn  Tyr Leu Lys 
    2285                 2290                 2295             


Asn Val  Val Lys Gln Ile Tyr  Gln Asp Leu Phe Gln  Asp Cys His 
    2300                 2305                 2310             


Phe Tyr  His 
    2315     


<210> 7056
<211> 237
<212> PRT
<213> Homo sapiens

<400> 7056
Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Arg Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly 
            20                  25                  30          


Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly Gly Cys 
        35                  40                  45              


Gly Ser Gly Cys Ala Gly Cys Gly Gly Cys Gly Ser Gly Cys Cys Val 
    50                  55                  60                  


Pro Val Cys Cys Cys Lys Pro Met Cys Cys Cys Val Pro Ala Cys Ser 
65                  70                  75                  80  


Cys Ser Ser Cys Gly Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys 
                85                  90                  95      


Arg Gly Cys Val Ser Cys Gly Val Ser Lys Gly Ala Cys Gly Ser Cys 
            100                 105                 110         


Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly 
        115                 120                 125             


Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly 
    130                 135                 140                 


Ser Lys Gly Gly Cys Gly Ser Tyr Gly Cys Ser Gln Ser Ser Cys Cys 
145                 150                 155                 160 


Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser 
                165                 170                 175     


Ser Cys Cys Lys Pro Tyr Cys Cys Gln Ser Ser Cys Cys Lys Pro Tyr 
            180                 185                 190         


Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Ser Cys Phe Ser Gly Cys 
        195                 200                 205             


Gly Ser Ser Cys Cys Gln Ser Ser Cys Tyr Lys Pro Cys Cys Cys Gln 
    210                 215                 220                 


Ser Ser Cys Cys Val Pro Val Cys Cys Gln Cys Lys Ile 
225                 230                 235         


<210> 7057
<211> 238
<212> PRT
<213> Homo sapiens

<400> 7057
Met Gly Cys Ser Gly Cys Ser Gly Gly Cys Gly Ser Ser Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Ser Cys Gly Gly Cys Gly Ser Gly Tyr Gly Gly Cys Gly 
            20                  25                  30          


Ser Gly Cys Cys Val Pro Val Cys Cys Cys Lys Pro Val Cys Cys Cys 
        35                  40                  45              


Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys 
    50                  55                  60                  


Gly Val Cys Gly Ser Cys Gly Gly Cys Lys Gly Gly Cys Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Ser Lys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Val Cys 
                85                  90                  95      


Cys Ser Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys Gly Val Cys Gly 
            100                 105                 110         


Phe Arg Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln 
        115                 120                 125             


Cys Ser Cys Tyr Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser 
    130                 135                 140                 


Cys Cys Gln Ser Ser Cys Cys Lys Pro Ser Cys Ser Gln Ser Ser Cys 
145                 150                 155                 160 


Cys Lys Pro Cys Cys Ser Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys 
                165                 170                 175     


Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys Pro 
            180                 185                 190         


Cys Cys Ser Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly 
        195                 200                 205             


Cys Gly Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Ser Ser 
    210                 215                 220                 


Gln Ser Ser Cys Cys Val Pro Ile Cys Cys Gln Cys Lys Ile 
225                 230                 235             


<210> 7058
<211> 490
<212> PRT
<213> Homo sapiens

<400> 7058
Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu 
            20                  25                  30          


Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu 
        195                 200                 205             


Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly 
225                 230                 235                 240 


Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu 
                245                 250                 255     


Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser 
            260                 265                 270         


Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu 
        275                 280                 285             


Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala 
    290                 295                 300                 


Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Val Ala 
                325                 330                 335     


Gln Met Leu Ser Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr 
            340                 345                 350         


Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala 
        355                 360                 365             


Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr 
    370                 375                 380                 


Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu 
385                 390                 395                 400 


Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe 
                405                 410                 415     


Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile 
            420                 425                 430         


Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe 
        435                 440                 445             


Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln 
    450                 455                 460                 


Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu 
465                 470                 475                 480 


Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
                485                 490 


<210> 7059
<211> 1941
<212> PRT
<213> Homo sapiens

<400> 7059
Leu Leu Thr Ser Val Leu Met Pro Ser Phe Gly Tyr Phe Ile Arg Ser 
1               5                   10                  15      


Pro Glu Lys Arg Glu Pro Ile Ala Leu Ile Arg Lys Ser Asp Val Ser 
            20                  25                  30          


Arg Gly Asn Leu Glu Lys Glu Met Ala His Leu Asn His Asp Leu Tyr 
        35                  40                  45              


Ser Gly Asp Leu Asn Glu Gln Ser Gln Ala Gln Leu Ser Glu Gly Ser 
    50                  55                  60                  


Ile Thr Leu Gln Val Glu Ala Val Glu Ser Thr Ser Gln Val Asp Glu 
65                  70                  75                  80  


Asn Asp Val Thr Leu Thr Ala Asp Lys Gly Lys Thr Glu Asp Thr Phe 
                85                  90                  95      


Phe Met Ser Asn Lys Pro Gln Arg Tyr Lys Asp Lys Leu Pro Asp Ser 
            100                 105                 110         


Gly Asp Ser Met Leu Arg Ile Ser Thr Ile Ala Ser Ala Ile Ala Glu 
        115                 120                 125             


Ala Ser Val Asn Thr Asp Pro Ser Gln Leu Ala Ala Met Ile Lys Ala 
    130                 135                 140                 


Leu Ser Asn Lys Thr Arg Asp Lys Thr Phe Gln Glu Asp Glu Lys Gln 
145                 150                 155                 160 


Lys Asp Tyr Ser His Val Arg His Phe Leu Pro Asn Asp Leu Glu Lys 
                165                 170                 175     


Ser Asn Gly Ser Asn Ala Leu Asp Met Glu Lys Tyr Leu Lys Lys Thr 
            180                 185                 190         


Glu Val Ser Arg Tyr Glu Ser Ala Leu Glu Asn Phe Ser Arg Ala Ser 
        195                 200                 205             


Met Ser Asp Thr Trp Asp Leu Ser Leu Pro Lys Glu Gln Thr Thr Gln 
    210                 215                 220                 


Asp Ile His Pro Val Asp Leu Ser Ala Thr Ser Val Ser Val Arg Ala 
225                 230                 235                 240 


Pro Glu Glu Asn Thr Ala Ala Ile Val Tyr Val Glu Asn Gly Glu Ser 
                245                 250                 255     


Glu Asn Gln Glu Ser Phe Arg Thr Ile Asn Ser Ser Asn Ser Val Thr 
            260                 265                 270         


Asn Arg Glu Asn Asn Ser Ala Val Val Asp Val Lys Thr Cys Ser Ile 
        275                 280                 285             


Asp Asn Lys Leu Gln Asp Val Gly Asn Asp Glu Lys Ala Thr Ser Ile 
    290                 295                 300                 


Ser Thr Pro Ser Asp Ser Tyr Ser Ser Val Arg Asn Pro Arg Ile Thr 
305                 310                 315                 320 


Ser Leu Cys Leu Leu Lys Asp Cys Glu Glu Ile Arg Asp Asn Arg Glu 
                325                 330                 335     


Asn Gln Arg Gln Asn Glu Cys Val Ser Glu Ile Ser Asn Ser Glu Lys 
            340                 345                 350         


His Val Thr Phe Glu Asn His Arg Ile Val Ser Pro Lys Asn Ser Asp 
        355                 360                 365             


Leu Lys Asn Thr Ser Pro Glu His Gly Gly Arg Gly Ser Glu Asp Glu 
    370                 375                 380                 


Gln Glu Ser Phe Arg Pro Ser Thr Ser Pro Leu Ser His Ser Ser Pro 
385                 390                 395                 400 


Ser Glu Ile Ser Gly Thr Ser Ser Ser Gly Cys Ala Leu Glu Ser Phe 
                405                 410                 415     


Gly Ser Ala Ala Gln Gln Gln Gln Pro Pro Cys Glu Gln Glu Leu Ser 
            420                 425                 430         


Pro Leu Val Cys Ser Pro Ala Gly Val Ser Arg Leu Thr Tyr Val Ser 
        435                 440                 445             


Glu Pro Glu Ser Ser Tyr Pro Thr Thr Ala Thr Asp Asp Ala Leu Glu 
    450                 455                 460                 


Asp Arg Lys Ser Asp Ile Thr Ser Glu Leu Ser Thr Thr Ile Ile Gln 
465                 470                 475                 480 


Gly Ser Pro Ala Ala Leu Glu Glu Arg Ala Met Glu Lys Leu Arg Glu 
                485                 490                 495     


Lys Val Pro Phe Gln Asn Arg Gly Lys Gly Thr Leu Ser Ser Ile Ile 
            500                 505                 510         


Gln Asn Asn Ser Asp Thr Arg Lys Ala Thr Glu Thr Thr Ser Leu Ser 
        515                 520                 525             


Ser Lys Pro Glu Tyr Val Lys Pro Asp Phe Arg Trp Ser Lys Asp Pro 
    530                 535                 540                 


Ser Ser Lys Ser Gly Asn Leu Leu Glu Thr Ser Glu Val Gly Trp Thr 
545                 550                 555                 560 


Ser Asn Pro Glu Glu Leu Asp Pro Ile Arg Leu Ala Leu Leu Gly Lys 
                565                 570                 575     


Ser Gly Leu Ser Cys Gln Val Gly Ser Ala Thr Ser His Pro Val Ser 
            580                 585                 590         


Cys Gln Glu Pro Ile Asp Glu Asp Gln Arg Ile Ser Pro Lys Asp Lys 
        595                 600                 605             


Ser Thr Ala Gly Arg Glu Phe Ser Gly Gln Val Ser His Gln Thr Thr 
    610                 615                 620                 


Ser Glu Asn Gln Cys Thr Pro Ile Pro Ser Ser Thr Val His Ser Ser 
625                 630                 635                 640 


Val Ala Asp Met Gln Asn Met Pro Ala Ala Val His Ala Leu Leu Thr 
                645                 650                 655     


Gln Pro Ser Leu Ser Ala Ala Pro Phe Ala Gln Arg Tyr Leu Gly Thr 
            660                 665                 670         


Leu Pro Ser Thr Gly Ser Thr Thr Leu Pro Gln Cys His Ala Gly Asn 
        675                 680                 685             


Ala Thr Val Cys Gly Phe Ser Gly Gly Leu Pro Tyr Pro Ala Val Ala 
    690                 695                 700                 


Gly Glu Pro Val Gln Asn Ser Val Ala Val Gly Ile Cys Leu Gly Ser 
705                 710                 715                 720 


Asn Ile Gly Ser Gly Trp Met Gly Thr Ser Ser Leu Cys Asn Pro Tyr 
                725                 730                 735     


Ser Asn Thr Leu Asn Gln Asn Leu Leu Ser Thr Thr Lys Pro Phe Pro 
            740                 745                 750         


Val Pro Ser Val Gly Thr Asn Cys Gly Ile Glu Pro Trp Asp Ser Gly 
        755                 760                 765             


Val Thr Ser Gly Leu Gly Ser Val Arg Val Pro Glu Glu Leu Lys Leu 
    770                 775                 780                 


Pro His Ala Cys Cys Val Gly Ile Ala Ser Gln Thr Leu Leu Ser Val 
785                 790                 795                 800 


Leu Asn Pro Thr Asp Arg Trp Leu Gln Val Ser Ile Gly Val Leu Ser 
                805                 810                 815     


Ile Ser Val Asn Gly Glu Lys Val Asp Leu Ser Thr Tyr Arg Cys Leu 
            820                 825                 830         


Val Phe Lys Asn Lys Ala Ile Ile Arg Pro His Ala Thr Glu Glu Ile 
        835                 840                 845             


Lys Val Leu Phe Ile Pro Ser Ser Pro Gly Val Phe Arg Cys Thr Phe 
    850                 855                 860                 


Ser Val Ala Ser Trp Pro Cys Ser Thr Asp Ala Glu Thr Ile Val Gln 
865                 870                 875                 880 


Ala Glu Ala Leu Ala Ser Thr Val Thr Leu Thr Ala Ile Ala Glu Ser 
                885                 890                 895     


Pro Val Ile Glu Val Glu Thr Glu Lys Lys Asp Val Leu Asp Phe Gly 
            900                 905                 910         


Asp Leu Thr Tyr Gly Gly Trp Lys Ala Leu Pro Leu Lys Leu Ile Asn 
        915                 920                 925             


Arg Thr His Ala Thr Val Pro Ile Arg Leu Ile Ile Asn Ala Asn Ala 
    930                 935                 940                 


Val Ala Trp Arg Cys Phe Thr Phe Ser Lys Glu Ser Val Arg Ala Pro 
945                 950                 955                 960 


Val Glu Val Ala Pro Cys Ala Asp Val Val Thr Arg Leu Ala Gly Pro 
                965                 970                 975     


Ser Val Val Asn His Met Met Pro Ala Ser Tyr Asp Gly Gln Asp Pro 
            980                 985                 990         


Glu Phe Leu Met Ile Trp Val Leu  Phe His Ser Pro Lys  Lys Gln Ile 
        995                 1000                 1005             


Ser Ser  Ser Asp Ile Leu Asp  Ser Ala Glu Glu Phe  Ser Ala Lys 
    1010                 1015                 1020             


Val Asp  Ile Glu Val Asp Ser  Pro Asn Pro Thr Pro  Val Leu Arg 
    1025                 1030                 1035             


Ser Val  Ser Leu Arg Ala Arg  Ala Gly Ile Ala Arg  Ile His Ala 
    1040                 1045                 1050             


Pro Arg  Asp Leu Gln Thr Met  His Phe Leu Ala Lys  Val Ala Ser 
    1055                 1060                 1065             


Ser Arg  Lys Gln His Leu Pro  Leu Lys Asn Ala Gly  Asn Ile Glu 
    1070                 1075                 1080             


Val Tyr  Leu Asp Ile Lys Val  Pro Glu Gln Gly Ser  His Phe Ser 
    1085                 1090                 1095             


Val Asp  Pro Lys Asn Leu Leu  Leu Lys Pro Gly Glu  Glu His Glu 
    1100                 1105                 1110             


Val Ile  Val Ser Phe Thr Pro  Lys Asp Pro Glu Ala  Cys Glu Glu 
    1115                 1120                 1125             


Arg Ile  Leu Lys Ile Phe Val  Gln Pro Phe Gly Pro  Gln Tyr Glu 
    1130                 1135                 1140             


Val Val  Leu Lys Gly Glu Val  Ile Ser Ser Gly Ser  Lys Pro Leu 
    1145                 1150                 1155             


Ser Pro  Gly Pro Cys Leu Asp  Ile Pro Ser Ile Leu  Ser Asn Lys 
    1160                 1165                 1170             


Gln Phe  Leu Ala Trp Gly Gly  Val Pro Leu Gly Arg  Thr Gln Leu 
    1175                 1180                 1185             


Gln Lys  Leu Ala Leu Arg Asn  Asn Ser Ala Ser Thr  Thr Gln His 
    1190                 1195                 1200             


Leu Arg  Leu Leu Ile Arg Gly  Gln Asp Gln Asp Cys  Phe Gln Leu 
    1205                 1210                 1215             


Gln Asn  Thr Phe Gly Ser Glu  Gln Arg Leu Thr Ser  Asn Cys Glu 
    1220                 1225                 1230             


Ile Arg  Ile His Pro Lys Glu  Asp Ile Phe Ile Ser  Val Leu Phe 
    1235                 1240                 1245             


Ala Pro  Thr Arg Leu Ser Cys  Met Leu Ala Arg Leu  Glu Ile Lys 
    1250                 1255                 1260             


Gln Leu  Gly Asn Arg Ser Gln  Pro Gly Ile Lys Phe  Thr Ile Pro 
    1265                 1270                 1275             


Leu Ser  Gly Tyr Gly Gly Thr  Ser Asn Leu Ile Leu  Glu Gly Val 
    1280                 1285                 1290             


Lys Lys  Leu Ser Asp Ser Tyr  Met Val Thr Val Asn  Gly Leu Val 
    1295                 1300                 1305             


Pro Gly  Lys Glu Ser Lys Ile  Val Phe Ser Val Arg  Asn Thr Gly 
    1310                 1315                 1320             


Ser Arg  Ala Ala Phe Val Lys  Ala Val Gly Phe Lys  Asp Ser Gln 
    1325                 1330                 1335             


Lys Lys  Val Leu Leu Asp Pro  Lys Val Leu Arg Ile  Phe Pro Asp 
    1340                 1345                 1350             


Lys Phe  Val Leu Lys Glu Arg  Thr Gln Glu Asn Val  Thr Leu Ile 
    1355                 1360                 1365             


Tyr Asn  Pro Ser Asp Arg Gly  Ile Asn Asn Lys Thr  Ala Thr Glu 
    1370                 1375                 1380             


Leu Ser  Thr Val Tyr Leu Phe  Gly Gly Asp Glu Ile  Ser Arg Gln 
    1385                 1390                 1395             


Gln Tyr  Arg Arg Ala Leu Leu  His Lys Pro Glu Met  Ile Lys Gln 
    1400                 1405                 1410             


Ile Leu  Pro Glu His Ser Val  Leu Gln Asn Ile Asn  Phe Val Glu 
    1415                 1420                 1425             


Ala Phe  Gln Asp Glu Leu Leu  Val Thr Glu Val Tyr  Asp Leu Pro 
    1430                 1435                 1440             


Gln Arg  Pro Asn Asp Val Gln  Leu Phe Tyr Gly Ser  Met Cys Lys 
    1445                 1450                 1455             


Ile Ile  Leu Ser Val Ile Gly  Glu Phe Arg Asp Cys  Ile Ser Ser 
    1460                 1465                 1470             


Arg Glu  Phe Leu Gln Pro Ser  Ser Lys Ala Ser Leu  Glu Ser Thr 
    1475                 1480                 1485             


Ser Asp  Leu Gly Ala Ser Gly  Lys His Gly Gly Asn  Val Ser Leu 
    1490                 1495                 1500             


Asp Val  Leu Pro Val Lys Gly  Pro Gln Gly Ser Pro  Leu Leu Ser 
    1505                 1510                 1515             


Arg Ala  Ala Arg Pro Pro Leu  Asp Gln Leu Ala Ser  Glu Glu Pro 
    1520                 1525                 1530             


Trp Thr  Val Leu Pro Glu His  Leu Ile Leu Val Ala  Pro Ser Pro 
    1535                 1540                 1545             


Cys Asp  Met Ala Lys Thr Gly  Arg Phe Gln Ile Val  Asn Asn Ser 
    1550                 1555                 1560             


Val Arg  Leu Leu Arg Phe Glu  Leu Cys Trp Pro Ala  His Cys Leu 
    1565                 1570                 1575             


Thr Val  Thr Pro Gln His Gly  Cys Val Ala Pro Glu  Ser Lys Leu 
    1580                 1585                 1590             


Gln Ile  Leu Val Ser Pro Asn  Ser Ser Leu Ser Thr  Lys Gln Ser 
    1595                 1600                 1605             


Met Phe  Pro Trp Ser Gly Leu  Ile Tyr Ile His Cys  Asp Asp Gly 
    1610                 1615                 1620             


Gln Lys  Lys Ile Val Lys Val  Gln Ile Arg Glu Asp  Leu Thr Gln 
    1625                 1630                 1635             


Val Glu  Leu Leu Thr Arg Leu  Thr Ser Lys Pro Phe  Gly Ile Leu 
    1640                 1645                 1650             


Ser Pro  Val Ser Glu Pro Ser  Val Ser His Leu Val  Lys Pro Met 
    1655                 1660                 1665             


Thr Lys  Pro Pro Ser Thr Lys  Val Glu Ile Arg Asn  Lys Ser Ile 
    1670                 1675                 1680             


Thr Phe  Pro Thr Thr Glu Pro  Gly Glu Thr Ser Glu  Ser Cys Leu 
    1685                 1690                 1695             


Glu Leu  Glu Asn His Gly Thr  Thr Asp Val Lys Trp  His Leu Ser 
    1700                 1705                 1710             


Ser Leu  Ala Pro Pro Tyr Val  Lys Gly Val Asp Glu  Ser Gly Asp 
    1715                 1720                 1725             


Val Phe  Arg Ala Thr Tyr Ala  Ala Phe Arg Cys Ser  Pro Ile Ser 
    1730                 1735                 1740             


Gly Leu  Leu Glu Ser His Gly  Ile Gln Lys Val Ser  Ile Thr Phe 
    1745                 1750                 1755             


Leu Pro  Arg Gly Arg Gly Asp  Tyr Ala Gln Phe Trp  Asp Val Glu 
    1760                 1765                 1770             


Cys His  Pro Leu Lys Glu Pro  His Met Lys His Thr  Leu Arg Phe 
    1775                 1780                 1785             


Gln Leu  Ser Gly Gln Ser Ile  Glu Ala Glu Asn Glu  Pro Glu Asn 
    1790                 1795                 1800             


Ala Cys  Leu Ser Thr Asp Ser  Leu Ile Lys Ile Asp  His Leu Val 
    1805                 1810                 1815             


Lys Pro  Arg Arg Gln Ala Val  Ser Glu Ala Ser Ala  Arg Ile Pro 
    1820                 1825                 1830             


Glu Gln  Leu Asp Val Thr Ala  Arg Gly Val Tyr Ala  Pro Glu Asp 
    1835                 1840                 1845             


Val Tyr  Arg Phe Arg Pro Thr  Ser Val Gly Glu Ser  Arg Thr Leu 
    1850                 1855                 1860             


Lys Val  Asn Leu Arg Asn Asn  Ser Phe Ile Thr His  Ser Leu Lys 
    1865                 1870                 1875             


Phe Leu  Ser Pro Arg Glu Pro  Phe Tyr Val Lys His  Ser Lys Tyr 
    1880                 1885                 1890             


Ser Leu  Arg Ala Gln His Tyr  Ile Asn Met Pro Val  Gln Phe Lys 
    1895                 1900                 1905             


Pro Lys  Ser Ala Gly Lys Phe  Glu Ala Leu Leu Val  Ile Gln Thr 
    1910                 1915                 1920             


Asp Glu  Gly Lys Ser Ile Ala  Ile Arg Leu Ile Gly  Glu Ala Leu 
    1925                 1930                 1935             


Gly Lys  Asn 
    1940     


<210> 7060
<211> 36
<212> PRT
<213> Homo sapiens

<400> 7060
Met Cys Tyr Tyr Gly Asn Tyr Tyr Gly Gly Tyr Gly Tyr Gly Gly Leu 
1               5                   10                  15      


Gly Cys Gly Tyr Gly Ser Cys Cys Gly Cys Gly Phe Arg Arg Leu Gly 
            20                  25                  30          


Cys Gly Tyr Gly 
        35      


<210> 7061
<211> 175
<212> PRT
<213> Homo sapiens

<400> 7061
Met Ser Tyr Asn Cys Cys Ser Gly Asn Phe Ser Ser Arg Ser Cys Gly 
1               5                   10                  15      


Asp Tyr Leu Arg Tyr Pro Ala Ser Ser Arg Gly Phe Ser Tyr Pro Ser 
            20                  25                  30          


Asn Leu Val Tyr Ser Thr Asp Leu Cys Ser Pro Ser Thr Cys Gln Leu 
        35                  40                  45              


Gly Ser Ser Leu Tyr Arg Gly Cys Gln Glu Ile Cys Trp Glu Pro Thr 
    50                  55                  60                  


Ser Cys Gln Thr Ser Tyr Val Glu Ser Ser Pro Cys Gln Thr Ser Cys 
65                  70                  75                  80  


Tyr Arg Pro Arg Thr Ser Leu Leu Cys Ser Pro Cys Lys Thr Thr Tyr 
                85                  90                  95      


Ser Gly Ser Leu Gly Phe Gly Ser Ser Ser Cys Arg Ser Leu Gly Tyr 
            100                 105                 110         


Gly Ser Arg Ser Cys Tyr Ser Val Gly Cys Gly Ser Ser Gly Val Arg 
        115                 120                 125             


Ser Leu Gly Tyr Gly Ser Cys Gly Phe Pro Ser Leu Gly Tyr Gly Ser 
    130                 135                 140                 


Gly Phe Cys Arg Pro Thr Tyr Leu Ala Ser Arg Ser Cys Gln Ser Pro 
145                 150                 155                 160 


Cys Tyr Arg Pro Ala Tyr Gly Ser Thr Phe Cys Arg Ser Thr Cys 
                165                 170                 175 


<210> 7062
<211> 107
<212> PRT
<213> Homo sapiens

<400> 7062
Met Gly Lys Lys Arg Thr Lys Gly Lys Thr Val Pro Ile Asp Asp Ser 
1               5                   10                  15      


Ser Glu Thr Leu Glu Pro Val Cys Arg His Ile Arg Lys Gly Leu Glu 
            20                  25                  30          


Gln Gly Asn Leu Lys Lys Ala Leu Val Asn Val Glu Trp Asn Ile Cys 
        35                  40                  45              


Gln Asp Cys Lys Thr Asp Asn Lys Val Lys Asp Lys Ala Glu Glu Glu 
    50                  55                  60                  


Thr Glu Glu Lys Pro Ser Val Trp Leu Cys Leu Lys Cys Gly His Gln 
65                  70                  75                  80  


Gly Cys Gly Arg Asn Ser Gln Glu Gln His Ala Leu Lys His Tyr Leu 
                85                  90                  95      


Thr Pro Arg Ser Glu Pro His Cys Leu Val Leu 
            100                 105         


<210> 7063
<211> 822
<212> PRT
<213> Homo sapiens

<400> 7063
Met Gly Lys Lys Arg Thr Lys Gly Lys Thr Val Pro Ile Asp Asp Ser 
1               5                   10                  15      


Ser Glu Thr Leu Glu Pro Val Cys Arg His Ile Arg Lys Gly Leu Glu 
            20                  25                  30          


Gln Gly Asn Leu Lys Lys Ala Leu Val Asn Val Glu Trp Asn Ile Cys 
        35                  40                  45              


Gln Asp Cys Lys Thr Asp Asn Lys Val Lys Asp Lys Ala Glu Glu Glu 
    50                  55                  60                  


Thr Glu Glu Lys Pro Ser Val Trp Leu Cys Leu Lys Cys Gly His Gln 
65                  70                  75                  80  


Gly Cys Gly Arg Asn Ser Gln Glu Gln His Ala Leu Lys His Tyr Leu 
                85                  90                  95      


Thr Pro Arg Ser Glu Pro His Cys Leu Val Leu Ser Leu Asp Asn Trp 
            100                 105                 110         


Ser Val Trp Cys Tyr Val Cys Asp Asn Glu Val Gln Tyr Cys Ser Ser 
        115                 120                 125             


Asn Gln Leu Gly Gln Val Val Asp Tyr Val Arg Lys Gln Ala Ser Ile 
    130                 135                 140                 


Thr Thr Pro Lys Pro Glu Lys Asp Asn Gly Asn Ile Glu Leu Glu Asn 
145                 150                 155                 160 


Lys Lys Leu Glu Lys Glu Ser Lys Asn Glu Gln Glu Arg Glu Lys Lys 
                165                 170                 175     


Glu Asn Met Ala Lys Glu Asn Pro Pro Met Asn Ser Pro Cys Gln Ile 
            180                 185                 190         


Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn Ala 
        195                 200                 205             


Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu Lys 
    210                 215                 220                 


Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp Leu 
225                 230                 235                 240 


Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro Leu 
                245                 250                 255     


Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys Lys 
            260                 265                 270         


Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys Ala 
        275                 280                 285             


Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Arg 
    290                 295                 300                 


Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser Lys 
305                 310                 315                 320 


Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu Glu 
                325                 330                 335     


Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro Ser 
            340                 345                 350         


Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met Cys 
        355                 360                 365             


Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp Leu 
    370                 375                 380                 


Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn Asp 
385                 390                 395                 400 


Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu Glu 
                405                 410                 415     


Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro Ser 
            420                 425                 430         


Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys Lys 
        435                 440                 445             


Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val Leu 
    450                 455                 460                 


His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu Tyr 
465                 470                 475                 480 


Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn His 
                485                 490                 495     


Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln Lys 
            500                 505                 510         


Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn Gln 
        515                 520                 525             


Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn Asp 
    530                 535                 540                 


Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala Tyr 
545                 550                 555                 560 


Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe Lys 
                565                 570                 575     


Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile Glu 
            580                 585                 590         


Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val Val 
        595                 600                 605             


Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu Val 
    610                 615                 620                 


Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe Thr 
625                 630                 635                 640 


Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val Cys 
                645                 650                 655     


Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu Arg 
            660                 665                 670         


Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu Ala 
        675                 680                 685             


Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly Phe 
    690                 695                 700                 


Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu Asp 
705                 710                 715                 720 


Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu Asn 
                725                 730                 735     


Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly Thr 
            740                 745                 750         


Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala Asn 
        755                 760                 765             


Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp Phe 
    770                 775                 780                 


Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His Val 
785                 790                 795                 800 


Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu Leu 
                805                 810                 815     


Phe Tyr Glu Arg Ile Leu 
            820         


<210> 7064
<211> 823
<212> PRT
<213> Homo sapiens

<400> 7064
Met Gly Lys Lys Arg Thr Lys Gly Lys Thr Val Pro Ile Asp Asp Ser 
1               5                   10                  15      


Ser Glu Thr Leu Glu Pro Val Cys Arg His Ile Arg Lys Gly Leu Glu 
            20                  25                  30          


Gln Gly Asn Leu Lys Lys Ala Leu Val Asn Val Glu Trp Asn Ile Cys 
        35                  40                  45              


Gln Asp Cys Lys Thr Asp Asn Lys Val Lys Asp Lys Ala Glu Glu Glu 
    50                  55                  60                  


Thr Glu Glu Lys Pro Ser Val Trp Leu Cys Leu Lys Cys Gly His Gln 
65                  70                  75                  80  


Gly Cys Gly Arg Asn Ser Gln Glu Gln His Ala Leu Lys His Tyr Leu 
                85                  90                  95      


Thr Pro Arg Ser Glu Pro His Cys Leu Val Leu Ser Leu Asp Asn Trp 
            100                 105                 110         


Ser Val Trp Cys Tyr Val Cys Asp Asn Glu Val Gln Tyr Cys Ser Ser 
        115                 120                 125             


Asn Gln Leu Gly Gln Val Val Asp Tyr Val Arg Lys Gln Ala Ser Ile 
    130                 135                 140                 


Thr Thr Pro Lys Pro Ala Glu Lys Asp Asn Gly Asn Ile Glu Leu Glu 
145                 150                 155                 160 


Asn Lys Lys Leu Glu Lys Glu Ser Lys Asn Glu Gln Glu Arg Glu Lys 
                165                 170                 175     


Lys Glu Asn Met Ala Lys Glu Asn Pro Pro Met Asn Ser Pro Cys Gln 
            180                 185                 190         


Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
        195                 200                 205             


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
    210                 215                 220                 


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
225                 230                 235                 240 


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
                245                 250                 255     


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
            260                 265                 270         


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
        275                 280                 285             


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
    290                 295                 300                 


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
305                 310                 315                 320 


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
                325                 330                 335     


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
            340                 345                 350         


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
        355                 360                 365             


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
    370                 375                 380                 


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
385                 390                 395                 400 


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
                405                 410                 415     


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
            420                 425                 430         


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
        435                 440                 445             


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
    450                 455                 460                 


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
465                 470                 475                 480 


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
                485                 490                 495     


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
            500                 505                 510         


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
        515                 520                 525             


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
    530                 535                 540                 


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
545                 550                 555                 560 


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
                565                 570                 575     


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
            580                 585                 590         


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
        595                 600                 605             


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
    610                 615                 620                 


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
625                 630                 635                 640 


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
                645                 650                 655     


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
            660                 665                 670         


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
        675                 680                 685             


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
    690                 695                 700                 


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
705                 710                 715                 720 


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
                725                 730                 735     


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
            740                 745                 750         


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
        755                 760                 765             


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
    770                 775                 780                 


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
785                 790                 795                 800 


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
                805                 810                 815     


Leu Phe Tyr Glu Arg Ile Leu 
            820             


<210> 7065
<211> 388
<212> PRT
<213> Homo sapiens

<400> 7065
Met Asp Pro Ile Arg Ser Phe Cys Gly Lys Leu Arg Ser Leu Ala Ser 
1               5                   10                  15      


Thr Leu Asp Cys Glu Thr Ala Arg Leu Gln Arg Ala Leu Asp Gly Glu 
            20                  25                  30          


Glu Ser Asp Phe Glu Asp Tyr Pro Met Arg Ile Leu Tyr Asp Leu His 
        35                  40                  45              


Ser Glu Val Gln Thr Leu Lys Asp Asp Val Asn Ile Leu Leu Asp Lys 
    50                  55                  60                  


Ala Arg Leu Glu Asn Gln Glu Gly Ile Asp Phe Ile Lys Ala Thr Lys 
65                  70                  75                  80  


Val Leu Met Glu Lys Asn Ser Met Asp Ile Met Lys Ile Arg Glu Tyr 
                85                  90                  95      


Phe Gln Lys Tyr Gly Tyr Ser Pro Arg Val Lys Lys Asn Ser Val His 
            100                 105                 110         


Glu Gln Glu Ala Ile Asn Ser Asp Pro Glu Leu Ser Asn Cys Glu Asn 
        115                 120                 125             


Phe Gln Lys Thr Asp Val Lys Asp Asp Leu Ser Asp Pro Pro Val Ala 
    130                 135                 140                 


Ser Ser Cys Ile Ser Glu Lys Ser Pro Arg Ser Pro Gln Leu Ser Asp 
145                 150                 155                 160 


Phe Gly Leu Glu Arg Tyr Ile Val Ser Gln Val Leu Pro Asn Pro Pro 
                165                 170                 175     


Gln Ala Val Asn Asn Tyr Lys Glu Glu Pro Val Ile Val Thr Pro Pro 
            180                 185                 190         


Thr Lys Gln Ser Leu Val Lys Val Leu Lys Thr Pro Lys Cys Ala Leu 
        195                 200                 205             


Lys Met Asp Asp Phe Glu Cys Val Thr Pro Lys Leu Glu His Phe Gly 
    210                 215                 220                 


Ile Ser Glu Tyr Thr Met Cys Leu Asn Glu Asp Tyr Thr Met Gly Leu 
225                 230                 235                 240 


Lys Asn Ala Arg Asn Asn Lys Ser Glu Glu Ala Ile Asp Thr Glu Ser 
                245                 250                 255     


Arg Leu Asn Asp Asn Val Phe Ala Thr Pro Ser Pro Ile Ile Gln Gln 
            260                 265                 270         


Leu Glu Lys Ser Asp Ala Glu Tyr Thr Asn Ser Pro Leu Val Pro Thr 
        275                 280                 285             


Phe Cys Thr Pro Gly Leu Lys Ile Pro Ser Thr Lys Asn Ser Ile Ala 
    290                 295                 300                 


Leu Val Ser Thr Asn Tyr Pro Leu Ser Lys Thr Asn Ser Ser Ser Asn 
305                 310                 315                 320 


Asp Leu Glu Val Glu Asp Arg Thr Ser Leu Val Leu Asn Ser Asp Thr 
                325                 330                 335     


Cys Phe Glu Asn Leu Thr Asp Pro Ser Ser Pro Thr Ile Ser Ser Tyr 
            340                 345                 350         


Glu Asn Leu Leu Arg Thr Pro Thr Pro Pro Glu Val Thr Lys Ile Pro 
        355                 360                 365             


Glu Asp Ile Leu Gln Lys Phe Gln Trp Ile Tyr Pro Thr Gln Lys Leu 
    370                 375                 380                 


Asn Lys Met Arg 
385             


<210> 7066
<211> 450
<212> PRT
<213> Homo sapiens

<400> 7066
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Val Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Leu 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Ala Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ala Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Met Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu Gly Glu 
        435                 440                 445             


Glu Tyr 
    450 


<210> 7067
<211> 1125
<212> PRT
<213> Homo sapiens

<400> 7067
Met Thr Val Glu Gln Asn Val Leu Gln Gln Ser Ala Ala Gln Lys His 
1               5                   10                  15      


Gln Gln Thr Phe Leu Asn Gln Leu Arg Glu Ile Thr Gly Ile Asn Asp 
            20                  25                  30          


Thr Gln Ile Leu Gln Gln Ala Leu Lys Asp Ser Asn Gly Asn Leu Glu 
        35                  40                  45              


Leu Ala Val Ala Phe Leu Thr Ala Lys Asn Ala Lys Thr Pro Gln Gln 
    50                  55                  60                  


Glu Glu Thr Thr Tyr Tyr Gln Thr Ala Leu Pro Gly Asn Asp Arg Tyr 
65                  70                  75                  80  


Ile Ser Val Gly Ser Gln Ala Asp Thr Asn Val Ile Asp Leu Thr Gly 
                85                  90                  95      


Asp Asp Lys Asp Asp Leu Gln Arg Ala Ile Ala Leu Ser Leu Ala Glu 
            100                 105                 110         


Ser Asn Arg Ala Phe Arg Glu Thr Gly Ile Thr Asp Glu Glu Gln Ala 
        115                 120                 125             


Ile Ser Arg Val Leu Glu Ala Ser Ile Ala Glu Asn Lys Ala Cys Leu 
    130                 135                 140                 


Lys Arg Thr Pro Thr Glu Val Trp Arg Asp Ser Arg Asn Pro Tyr Asp 
145                 150                 155                 160 


Arg Lys Arg Gln Asp Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn 
                165                 170                 175     


Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu 
            180                 185                 190         


Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp 
        195                 200                 205             


Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu 
    210                 215                 220                 


Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val 
225                 230                 235                 240 


Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn 
                245                 250                 255     


Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp 
            260                 265                 270         


Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu 
        275                 280                 285             


Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu 
    290                 295                 300                 


Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe 
305                 310                 315                 320 


Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys 
                325                 330                 335     


Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu 
            340                 345                 350         


Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro 
        355                 360                 365             


Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly 
    370                 375                 380                 


Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr 
385                 390                 395                 400 


Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg 
                405                 410                 415     


Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg 
            420                 425                 430         


Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu 
        435                 440                 445             


Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val 
    450                 455                 460                 


Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly 
465                 470                 475                 480 


Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala 
                485                 490                 495     


Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile 
            500                 505                 510         


Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro 
        515                 520                 525             


Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile Thr Glu Glu Glu 
    530                 535                 540                 


Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu 
545                 550                 555                 560 


Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr 
                565                 570                 575     


Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg 
            580                 585                 590         


Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn Ala Gly His Tyr 
        595                 600                 605             


Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn 
    610                 615                 620                 


Asp Ile Ala Val Thr Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser 
625                 630                 635                 640 


Phe Gly Gly Tyr Arg Asn Ala Ser Ala Tyr Cys Leu Met Tyr Ile Asn 
                645                 650                 655     


Asp Lys Ala Gln Phe Leu Ile Gln Glu Glu Phe Asn Lys Glu Thr Gly 
            660                 665                 670         


Gln Pro Leu Val Gly Ile Glu Thr Leu Pro Pro Asp Leu Arg Asp Phe 
        675                 680                 685             


Val Glu Glu Asp Asn Gln Arg Phe Glu Lys Glu Leu Glu Glu Trp Asp 
    690                 695                 700                 


Ala Gln Leu Ala Gln Lys Ala Leu Gln Glu Lys Leu Leu Ala Ser Gln 
705                 710                 715                 720 


Lys Leu Arg Glu Ser Glu Thr Ser Val Thr Thr Ala Gln Ala Ala Gly 
                725                 730                 735     


Asp Pro Glu Tyr Leu Glu Gln Pro Ser Arg Ser Asp Phe Ser Lys His 
            740                 745                 750         


Leu Lys Glu Glu Thr Ile Gln Ile Ile Thr Lys Ala Ser His Glu His 
        755                 760                 765             


Glu Asp Lys Ser Pro Glu Thr Val Leu Gln Ser Lys Pro Glu Asn Thr 
    770                 775                 780                 


Thr Ser Gln Pro Leu Ser Asn Gln Arg Val Val Glu Val Ala Ile Pro 
785                 790                 795                 800 


His Val Gly Lys Phe Met Ile Glu Ser Lys Glu Gly Gly Tyr Asp Asp 
                805                 810                 815     


Glu Ile Met Met Thr Pro Asn Met Gln Gly Ile Ile Met Ala Ile Gly 
            820                 825                 830         


Lys Ser Arg Ser Val Tyr Asp Arg Cys Gly Pro Glu Ala Gly Phe Phe 
        835                 840                 845             


Lys Ala Ile Lys Leu Glu Tyr Ala Arg Leu Val Lys Leu Ala Gln Glu 
    850                 855                 860                 


Asp Thr Pro Pro Glu Thr Asp Tyr Arg Leu His His Val Val Val Tyr 
865                 870                 875                 880 


Phe Ile Gln Asn Gln Ala Pro Lys Lys Ile Ile Glu Lys Thr Leu Leu 
                885                 890                 895     


Glu Gln Phe Gly Asp Arg Asn Leu Ser Phe Asp Glu Arg Cys His Asn 
            900                 905                 910         


Ile Met Lys Val Ala Gln Ala Lys Leu Glu Met Ile Lys Pro Glu Glu 
        915                 920                 925             


Val Asn Leu Glu Glu Tyr Glu Glu Trp His Gln Asp Tyr Arg Lys Phe 
    930                 935                 940                 


Arg Glu Thr Thr Met Tyr Leu Ile Ile Gly Leu Glu Asn Phe Gln Arg 
945                 950                 955                 960 


Glu Ser Tyr Ile Asp Ser Leu Leu Phe Leu Ile Cys Ala Tyr Gln Asn 
                965                 970                 975     


Asn Lys Glu Leu Leu Ser Lys Gly Leu Tyr Arg Gly His Asp Glu Glu 
            980                 985                 990         


Leu Ile Ser His Tyr Arg Arg Glu  Cys Leu Leu Lys Leu  Asn Glu Gln 
        995                 1000                 1005             


Ala Ala  Glu Leu Phe Glu Ser  Gly Glu Asp Arg Glu  Val Asn Asn 
    1010                 1015                 1020             


Gly Leu  Ile Ile Met Asn Glu  Phe Ile Val Pro Phe  Leu Pro Leu 
    1025                 1030                 1035             


Leu Leu  Val Asp Glu Met Glu  Glu Lys Asp Ile Leu  Ala Val Glu 
    1040                 1045                 1050             


Asp Met  Arg Asn Arg Trp Cys  Ser Tyr Leu Gly Gln  Glu Met Glu 
    1055                 1060                 1065             


Pro His  Leu Gln Glu Lys Leu  Thr Asp Phe Leu Pro  Lys Leu Leu 
    1070                 1075                 1080             


Asp Cys  Ser Met Glu Ile Lys  Ser Phe His Glu Pro  Pro Lys Leu 
    1085                 1090                 1095             


Pro Ser  Tyr Ser Thr His Glu  Leu Cys Glu Arg Phe  Ala Arg Ile 
    1100                 1105                 1110             


Met Leu  Ser Leu Ser Arg Thr  Pro Ala Asp Gly Arg  
    1115                 1120                 1125 


<210> 7068
<211> 535
<212> PRT
<213> Homo sapiens

<400> 7068
Met Asp Leu Arg Gln Ala Cys Arg Thr Pro Ser Arg Asp Glu Ala Gly 
1               5                   10                  15      


Val Glu Leu Leu Met Thr Tyr Phe Ile Gln Leu Gly Phe Val Glu Ser 
            20                  25                  30          


Arg Phe Phe Pro Pro Thr Arg Gln Met Gly Leu Leu Phe Thr Trp Tyr 
        35                  40                  45              


Asp Ser Leu Thr Gly Val Pro Val Ser Gln Gln Asn Leu Leu Leu Glu 
    50                  55                  60                  


Lys Ala Ser Val Leu Phe Asn Thr Gly Ala Leu Tyr Thr Gln Ile Gly 
65                  70                  75                  80  


Thr Arg Cys Asp Arg Gln Thr Gln Ala Gly Leu Glu Ser Ala Ile Asp 
                85                  90                  95      


Ala Phe Gln Arg Ala Ala Gly Val Leu Asn Tyr Leu Lys Asp Thr Phe 
            100                 105                 110         


Thr His Thr Pro Ser Tyr Asp Met Ser Pro Ala Met Leu Ser Val Leu 
        115                 120                 125             


Val Lys Met Met Leu Ala Gln Ala Gln Glu Ser Val Phe Glu Lys Ile 
    130                 135                 140                 


Ser Leu Pro Gly Ile Arg Asn Glu Phe Phe Met Leu Val Lys Val Ala 
145                 150                 155                 160 


Gln Glu Ala Ala Lys Val Gly Glu Val Tyr Gln Gln Leu His Ala Ala 
                165                 170                 175     


Met Ser Gln Ala Pro Val Lys Glu Asn Ile Pro Tyr Ser Trp Ala Ser 
            180                 185                 190         


Leu Ala Cys Val Lys Ala His His Tyr Ala Ala Leu Ala His Tyr Phe 
        195                 200                 205             


Thr Ala Ile Leu Leu Ile Asp His Gln Val Lys Pro Gly Thr Asp Leu 
    210                 215                 220                 


Asp His Gln Glu Lys Cys Leu Ser Gln Leu Tyr Asp His Met Pro Glu 
225                 230                 235                 240 


Gly Leu Thr Pro Leu Ala Thr Leu Lys Asn Asp Gln Gln Arg Arg Gln 
                245                 250                 255     


Leu Gly Lys Ser His Leu Arg Arg Ala Met Ala His His Glu Glu Ser 
            260                 265                 270         


Val Arg Glu Ala Ser Leu Cys Lys Lys Leu Arg Ser Ile Glu Val Leu 
        275                 280                 285             


Gln Lys Val Leu Cys Ala Ala Gln Glu Arg Ser Arg Leu Thr Tyr Ala 
    290                 295                 300                 


Gln His Gln Glu Glu Asp Asp Leu Leu Asn Leu Ile Asp Ala Pro Ser 
305                 310                 315                 320 


Val Val Ala Lys Thr Glu Gln Glu Val Asp Ile Ile Leu Pro Gln Phe 
                325                 330                 335     


Ser Lys Leu Thr Val Thr Asp Phe Phe Gln Lys Leu Gly Pro Leu Ser 
            340                 345                 350         


Val Phe Ser Ala Asn Lys Arg Trp Thr Pro Pro Arg Ser Ile Arg Phe 
        355                 360                 365             


Thr Ala Glu Glu Gly Asp Leu Gly Phe Thr Leu Arg Gly Asn Ala Pro 
    370                 375                 380                 


Val Gln Val His Phe Leu Asp Pro Tyr Cys Ser Ala Ser Val Ala Gly 
385                 390                 395                 400 


Ala Arg Glu Gly Asp Tyr Ile Val Ser Ile Gln Leu Val Asp Cys Lys 
                405                 410                 415     


Trp Leu Thr Leu Ser Glu Val Met Lys Leu Leu Lys Ser Phe Gly Glu 
            420                 425                 430         


Asp Glu Ile Glu Met Lys Val Val Ser Leu Leu Asp Ser Thr Ser Ser 
        435                 440                 445             


Met His Asn Lys Ser Ala Thr Tyr Ser Val Gly Met Gln Lys Thr Tyr 
    450                 455                 460                 


Ser Met Ile Cys Leu Ala Ile Asp Asp Asp Asp Lys Thr Asp Lys Thr 
465                 470                 475                 480 


Lys Lys Ile Ser Lys Lys Leu Ser Phe Leu Ser Trp Gly Thr Asn Lys 
                485                 490                 495     


Asn Arg Gln Lys Ser Ala Ser Thr Leu Cys Leu Pro Ser Val Gly Ala 
            500                 505                 510         


Ala Arg Pro Gln Val Lys Lys Lys Leu Pro Ser Pro Phe Ser Leu Leu 
        515                 520                 525             


Asn Ser Asp Ser Ser Trp Tyr 
    530                 535 


<210> 7069
<211> 983
<212> PRT
<213> Homo sapiens

<400> 7069
Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp Leu Gln Lys 
                485                 490                 495     


Trp Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn His Ala Cys 
            500                 505                 510         


Leu Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser Ile Met Lys 
        515                 520                 525             


Arg Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg Tyr Gly Gly 
    530                 535                 540                 


Gly Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys Val Val Glu 
545                 550                 555                 560 


Arg Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu Asp Tyr Lys 
                565                 570                 575     


Thr Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Ser Asp Gly Phe 
            580                 585                 590         


Trp Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala Leu Glu 
        595                 600                 605             


Gln Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly Lys Met 
    610                 615                 620                 


Asn Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg Lys Glu 
625                 630                 635                 640 


Glu Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His Gly Glu 
                645                 650                 655     


Leu Cys Ile Ser Glu Asn Glu Arg Arg Leu Val Ser Lys Glu Ala Trp 
            660                 665                 670         


Ser Lys Leu Gln Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro Ser Tyr 
        675                 680                 685             


Lys Glu Cys Cys Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly Glu Glu 
    690                 695                 700                 


Asn Glu Ala Leu His Lys Met Ile Ala Asn Glu Gln Lys Thr Ser Leu 
705                 710                 715                 720 


Pro Asn Leu Phe Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn Trp Pro 
                725                 730                 735     


Glu Asp Thr Asp Val Leu Tyr Ile Val Ser Gln Phe Phe Val Glu Glu 
            740                 745                 750         


Trp Arg Lys Phe Val Arg Lys Pro Thr Arg Cys Ser Pro Val Ser Ser 
        755                 760                 765             


Val Gly Asn Ser Ala Leu Leu Cys Pro His Gly Gly Leu Met Phe Thr 
    770                 775                 780                 


Phe Ala Ser Met Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu Ile Trp 
785                 790                 795                 800 


Pro Ser Glu Trp Gln Met Ile Gln Lys Leu Phe Val Val Asp His Val 
                805                 810                 815     


Ile Lys Ile Thr Arg Ile Glu Val Gly Asp Val Asn Pro Ser Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ser Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu Gly Leu 
        835                 840                 845             


Leu Cys Gln Gln Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala Thr Ile 
    850                 855                 860                 


Tyr Val His Lys Val Val Asp Asn Lys Lys Val Met Lys Asp Ser Ala 
865                 870                 875                 880 


Pro Glu Leu Asn Val Ser Ser Ser Glu Thr Glu Glu Asp Lys Glu Glu 
                885                 890                 895     


Ala Lys Pro Asp Gly Glu Lys Asp Pro Asp Phe Asn Gln Ile Met His 
            900                 905                 910         


Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser Ile Asp Gly Lys 
        915                 920                 925             


Ile Leu Ser Asp Asp Cys Ala Thr Leu Gly Thr Leu Gly Val Ile Pro 
    930                 935                 940                 


Glu Ser Val Ile Leu Leu Lys Ala Asp Glu Pro Ile Ala Asp Tyr Ala 
945                 950                 955                 960 


Ala Met Asp Asp Val Met Gln Val Cys Met Pro Glu Glu Gly Phe Lys 
                965                 970                 975     


Gly Thr Gly Leu Leu Gly His 
            980             


<210> 7070
<211> 245
<212> PRT
<213> Homo sapiens

<400> 7070
Met Ser Val Cys Ser Ser Asp Leu Ser Tyr Gly Ser Arg Val Cys Leu 
1               5                   10                  15      


Pro Gly Ser Cys Asp Ser Cys Ser Asp Ser Trp Gln Val Asp Asp Cys 
            20                  25                  30          


Pro Glu Ser Cys Cys Glu Pro Pro Cys Cys Ala Pro Ala Pro Cys Leu 
        35                  40                  45              


Ser Leu Val Cys Thr Pro Val Ser Arg Val Ser Ser Pro Cys Cys Arg 
    50                  55                  60                  


Val Thr Cys Glu Pro Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys 
65                  70                  75                  80  


Thr Pro Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr 
                85                  90                  95      


Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Cys Cys Lys Thr 
            100                 105                 110         


Val Cys Cys Lys Pro Val Cys Cys Met Pro Val Cys Cys Gly Pro Ser 
        115                 120                 125             


Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Ile Ser 
    130                 135                 140                 


Ser Pro Cys Gln Gln Ser Cys Cys Val Pro Val Cys Cys Lys Pro Ile 
145                 150                 155                 160 


Cys Cys Val Pro Val Cys Ser Gly Ala Ser Ser Leu Cys Cys Gln Gln 
                165                 170                 175     


Ser Ser Cys Gln Pro Ala Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser 
            180                 185                 190         


Ser Ser Val Ser Leu Leu Cys Arg Pro Val Cys Arg Pro Ala Arg Arg 
        195                 200                 205             


Val Pro Val Pro Ser Cys Cys Val Pro Thr Ser Ser Cys Gln Pro Ser 
    210                 215                 220                 


Cys Gly Arg Leu Ala Ser Cys Gly Ser Leu Leu Cys Arg Pro Thr Cys 
225                 230                 235                 240 


Ser Arg Leu Ala Cys 
                245 


<210> 7071
<211> 365
<212> PRT
<213> Homo sapiens

<400> 7071
Met Ala Ala Ser Thr Met Ser Val Cys Ser Ser Asp Leu Ser Tyr Gly 
1               5                   10                  15      


Ser Arg Val Cys Leu Pro Gly Ser Cys Asp Ser Cys Ser Asp Ser Trp 
            20                  25                  30          


Gln Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Cys Ala 
        35                  40                  45              


Pro Ala Pro Cys Leu Ser Leu Val Cys Thr Pro Val Ser Arg Val Ser 
    50                  55                  60                  


Ser Pro Cys Cys Pro Val Thr Cys Glu Pro Ser Pro Cys Gln Ser Gly 
65                  70                  75                  80  


Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys Gln Gln Ser Ser Cys Gln 
                85                  90                  95      


Leu Ala Cys Cys Ala Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro 
            100                 105                 110         


Val Cys Cys Lys Thr Val Cys Cys Lys Pro Val Cys Cys Val Ser Val 
        115                 120                 125             


Cys Cys Gly Asp Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Ser Ala 
    130                 135                 140                 


Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Cys 
145                 150                 155                 160 


Cys Lys Pro Val Cys Ser Gly Ile Ser Ser Ser Cys Cys Gln Gln Ser 
                165                 170                 175     


Ser Cys Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Val Cys Glu 
            180                 185                 190         


Pro Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys 
        195                 200                 205             


Cys Gln Gln Ser Ser Cys Gln Pro Thr Cys Cys Thr Ser Ser Pro Cys 
    210                 215                 220                 


Gln Gln Ala Cys Cys Val Pro Val Cys Cys Val Pro Val Cys Cys Val 
225                 230                 235                 240 


Pro Thr Cys Ser Glu Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys 
                245                 250                 255     


Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln His Ala Cys Cys Val 
            260                 265                 270         


Pro Val Cys Ser Gly Ala Ser Thr Ser Cys Cys Gln Gln Ser Ser Cys 
        275                 280                 285             


Gln Pro Ala Cys Cys Thr Ala Ser Cys Cys Arg Pro Ser Ser Ser Val 
    290                 295                 300                 


Ser Leu Leu Cys His Pro Val Cys Lys Ser Thr Cys Cys Val Pro Val 
305                 310                 315                 320 


Pro Ser Cys Gly Ala Ser Ala Ser Ser Cys Gln Pro Ser Cys Cys Arg 
                325                 330                 335     


Thr Ala Ser Cys Val Ser Leu Leu Cys Arg Pro Met Cys Ser Arg Pro 
            340                 345                 350         


Ala Cys Tyr Ser Leu Cys Ser Gly Gln Lys Ser Ser Cys 
        355                 360                 365 


<210> 7072
<211> 271
<212> PRT
<213> Homo sapiens

<400> 7072
Met Ala Ala Cys Thr Met Ser Val Cys Ser Ser Ala Cys Ser Asp Ser 
1               5                   10                  15      


Trp Arg Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Gly 
            20                  25                  30          


Thr Ala Pro Cys Leu Thr Leu Val Cys Thr Pro Val Ser Cys Val Ser 
        35                  40                  45              


Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro Ser Pro Cys Gln Ser Gly 
    50                  55                  60                  


Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys Gln Pro Ala Cys Cys Ala 
65                  70                  75                  80  


Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro 
                85                  90                  95      


Val Cys Cys Leu Pro Thr Cys Ser Lys Asp Ser Ser Ser Cys Cys Gln 
            100                 105                 110         


Gln Ser Ser Cys Gln Pro Thr Cys Cys Ala Ser Ser Ser Cys Gln Gln 
        115                 120                 125             


Ser Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Val Pro Thr 
    130                 135                 140                 


Cys Ser Glu Asp Ser Ser Ser Cys Cys Gln His Ser Ser Cys Gln Pro 
145                 150                 155                 160 


Thr Cys Cys Thr Ser Ser Pro Cys Gln Gln Ser Cys Tyr Val Pro Val 
                165                 170                 175     


Cys Cys Lys Pro Val Cys Phe Lys Pro Ile Cys Cys Val Pro Val Cys 
            180                 185                 190         


Ser Gly Ala Ser Thr Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala 
        195                 200                 205             


Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu 
    210                 215                 220                 


Cys Arg Pro Ile Cys Arg Pro Ala Cys Cys Val Pro Ile Ser Ser Cys 
225                 230                 235                 240 


Cys Ala Pro Ala Ser Ser Tyr Gln Ala Ser Cys Cys Arg Pro Ala Ser 
                245                 250                 255     


Cys Val Ser Leu Leu Cys Arg Pro Ala Cys Ser Arg Leu Ala Cys 
            260                 265                 270     


<210> 7073
<211> 401
<212> PRT
<213> Homo sapiens

<400> 7073
Met Ser Val Cys Ser Ser Asp Leu Ser Tyr Ser Ser Arg Val Cys Leu 
1               5                   10                  15      


Pro Gly Ser Cys Asp Ser Cys Ser Asp Ser Trp Gln Val Asp Asp Cys 
            20                  25                  30          


Pro Glu Ser Cys Cys Glu Pro Pro Cys Cys Ala Pro Ser Cys Cys Ala 
        35                  40                  45              


Pro Ala Pro Cys Leu Ser Leu Val Cys Thr Pro Val Ser Arg Val Ser 
    50                  55                  60                  


Ser Pro Cys Cys Pro Val Thr Cys Glu Pro Ser Pro Cys Gln Ser Gly 
65                  70                  75                  80  


Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys Gln Gln Ser Ser Cys Gln 
                85                  90                  95      


Leu Ala Cys Cys Ala Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro 
            100                 105                 110         


Val Cys Cys Lys Thr Val Cys Cys Lys Pro Val Cys Cys Val Pro Val 
        115                 120                 125             


Cys Cys Gly Asp Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Ser Ala 
    130                 135                 140                 


Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Ile Cys 
145                 150                 155                 160 


Cys Lys Pro Val Cys Ser Gly Ile Ser Ser Ser Cys Cys Gln Gln Ser 
                165                 170                 175     


Ser Cys Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Val Cys Glu 
            180                 185                 190         


Pro Ser Pro Cys Gln Ser Gly Cys Ile Ser Ser Cys Thr Pro Ser Cys 
        195                 200                 205             


Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Ser Cys 
    210                 215                 220                 


Gln Gln Ala Cys Cys Val Pro Val Cys Cys Lys Thr Val Cys Cys Lys 
225                 230                 235                 240 


Pro Val Cys Ser Glu Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys 
                245                 250                 255     


Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val 
            260                 265                 270         


Pro Val Cys Cys Lys Pro Val Cys Cys Lys Pro Val Gly Ser Val Pro 
        275                 280                 285             


Ile Cys Ser Gly Ala Ser Ser Leu Cys Cys Gln Gln Ser Ser Cys Gln 
    290                 295                 300                 


Pro Ala Cys Cys Thr Ser Ser Gln Ser Gln Gln Gly Cys Cys Val Pro 
305                 310                 315                 320 


Val Cys Cys Lys Pro Val Ser Cys Val Pro Val Cys Ser Gly Ala Ser 
                325                 330                 335     


Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Thr 
            340                 345                 350         


Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Val 
        355                 360                 365             


Cys Arg Pro Ala Cys Cys Val Pro Val Pro Ser Cys Cys Ala Pro Thr 
    370                 375                 380                 


Ser Ser Cys Gln Pro Ser Cys Cys Arg Pro Ala Ser Cys Val Ser Leu 
385                 390                 395                 400 


Leu 
    


<210> 7074
<211> 282
<212> PRT
<213> Homo sapiens

<400> 7074
Met Ala Ala Ser Thr Met Ser Val Cys Ser Ser Ala Cys Ser Asp Ser 
1               5                   10                  15      


Trp Gln Val Asp Ala Cys Pro Glu Ser Cys Cys Glu Pro His Cys Cys 
            20                  25                  30          


Ala Leu Ser Cys Cys Ala Pro Ala Pro Cys Leu Thr Leu Val Cys Thr 
        35                  40                  45              


Pro Val Ser Arg Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro 
    50                  55                  60                  


Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys 
65                  70                  75                  80  


Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln 
                85                  90                  95      


Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Leu Pro 
            100                 105                 110         


Thr Cys Ser Lys Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln 
        115                 120                 125             


Pro Thr Cys Cys Ala Ser Ser Ser Ser Gln Gln Ser Cys Cys Val Pro 
    130                 135                 140                 


Val Cys Cys Lys Pro Val Cys Tyr Val Pro Thr Cys Ser Glu Asp Ser 
145                 150                 155                 160 


Ser Ser Cys Cys Gln Gln Ser Ser Cys His Pro Ala Cys Cys Thr Ser 
                165                 170                 175     


Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Arg Cys Lys Pro Val 
            180                 185                 190         


Cys Cys Lys Pro Ile Cys Cys Val Pro Val Cys Ser Gly Ala Ser Thr 
        195                 200                 205             


Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Thr Ser 
    210                 215                 220                 


Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Val Cys 
225                 230                 235                 240 


Arg Pro Ala Cys Cys Met Pro Val Ser Ser Cys Cys Ala Pro Ala Ser 
                245                 250                 255     


Ser Cys Gln Ala Ser Cys Cys Arg Pro Ala Ser Cys Val Ser Leu Leu 
            260                 265                 270         


Cys Arg Pro Ala Cys Ser Arg Pro Ala Cys 
        275                 280         


<210> 7075
<211> 296
<212> PRT
<213> Homo sapiens

<400> 7075
Met Ala Ser Ser Pro Leu Pro Gly Pro Asn Asp Ile Leu Leu Ala Ser 
1               5                   10                  15      


Pro Ser Ser Ala Phe Gln Pro Asp Thr Leu Ser Gln Pro Arg Pro Gly 
            20                  25                  30          


His Ala Asn Leu Lys Pro Asn Gln Val Gly Gln Val Ile Leu Tyr Gly 
        35                  40                  45              


Ile Pro Ile Val Ser Leu Val Ile Asp Gly Gln Glu Arg Leu Cys Leu 
    50                  55                  60                  


Ala Gln Ile Ser Asn Thr Leu Leu Lys Asn Phe Ser Tyr Asn Glu Ile 
65                  70                  75                  80  


His Asn Arg Arg Val Ala Leu Gly Ile Thr Cys Val Gln Cys Thr Pro 
                85                  90                  95      


Val Gln Leu Glu Ile Leu Arg Arg Ala Gly Ala Met Pro Ile Ser Ser 
            100                 105                 110         


Arg Arg Cys Gly Met Ile Thr Lys Arg Glu Ala Glu Arg Leu Cys Lys 
        115                 120                 125             


Ser Phe Leu Gly Glu Asn Arg Pro Pro Lys Leu Pro Asp Asn Phe Ala 
    130                 135                 140                 


Phe Asp Val Ser His Glu Cys Ala Trp Gly Cys Arg Gly Ser Phe Ile 
145                 150                 155                 160 


Pro Ala Arg Tyr Asn Ser Ser Arg Ala Lys Cys Ile Lys Cys Ser Tyr 
                165                 170                 175     


Cys Asn Met Tyr Phe Ser Pro Asn Lys Phe Ile Phe His Ser His Arg 
            180                 185                 190         


Thr Pro Asp Ala Lys Tyr Thr Gln Pro Asp Ala Ala Asn Phe Asn Ser 
        195                 200                 205             


Trp Arg Arg His Leu Lys Leu Thr Asp Lys Ser Pro Gln Asp Glu Leu 
    210                 215                 220                 


Val Phe Ala Trp Glu Asp Val Lys Ala Met Phe Asn Gly Gly Ser Arg 
225                 230                 235                 240 


Lys Arg Ala Leu Pro Gln Pro Gly Ala His Pro Ala Cys His Pro Leu 
                245                 250                 255     


Ser Ser Ile Arg Thr Arg Ser Ile Ala Phe Ser Ser Gln Thr Leu Met 
            260                 265                 270         


Leu Leu Glu Glu Ile Phe Gly Glu Lys Asp Gln Glu Asp Tyr Met Arg 
        275                 280                 285             


Ile Asn Glu Asp Asn Ile Trp Leu 
    290                 295     


<210> 7076
<211> 1781
<212> PRT
<213> Homo sapiens

<400> 7076
Val Lys Lys Ile His Arg His Arg Leu Ser Pro Ala Thr Glu Lys Gly 
1               5                   10                  15      


Ala Ala Ser Ser Gly Glu Gly Asp Lys Asp Pro Pro Pro Pro Ala His 
            20                  25                  30          


Glu Asp Ile Ala Val Lys Gly Thr Ala Thr Ala Ala Gly Thr Gly Pro 
        35                  40                  45              


Gly Thr Gly Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Pro Pro His 
    50                  55                  60                  


Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Val Pro Pro Pro His Pro Asn Ile Arg Ala Leu Gln Thr Gln 
                85                  90                  95      


Ala Pro Gln Gln Ile Pro Arg Gly Pro Val Gln Gln Pro Leu Glu Asp 
            100                 105                 110         


Arg Ile Phe Thr Pro Ala Val Ser Ala Val Tyr Ser Thr Val Thr Gln 
        115                 120                 125             


Val Ala Arg Gln Pro Gly Thr Pro Thr Pro Ser Pro Tyr Ser Ala His 
    130                 135                 140                 


Glu Ile Asn Lys Gly His Pro Asn Leu Ala Ala Thr Pro Pro Gly His 
145                 150                 155                 160 


Ala Ser Ser Pro Gly Leu Ser Gln Thr Pro Tyr Pro Ser Gly Gln Asn 
                165                 170                 175     


Ala Gly Pro Thr Thr Leu Val Tyr Pro Gln Thr Pro Gln Thr Met Asn 
            180                 185                 190         


Ser Gln Pro Gln Thr Arg Ser Pro Val Ile Phe Ser Pro Ser Gln Phe 
        195                 200                 205             


Phe Gln Arg Pro Gln Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser 
    210                 215                 220                 


Ser Pro Ser Ile Arg Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln 
225                 230                 235                 240 


Ala Asn Gln His Ile Met Met Val Asn His Leu Pro Met Pro Tyr Pro 
                245                 250                 255     


Val Pro Gln Gly Pro Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly 
            260                 265                 270         


Pro Pro Tyr Val Gly Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly 
        275                 280                 285             


Pro Gly Pro Phe Tyr Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala 
    290                 295                 300                 


Tyr Gly Thr Pro Phe Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro 
305                 310                 315                 320 


Ile Ile Val Pro Thr Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys 
                325                 330                 335     


Lys Thr Ile Arg Ile Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr 
            340                 345                 350         


Glu Glu Ile Met Ser Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile 
        355                 360                 365             


Gly Arg Pro Thr Ser Thr Pro Thr Pro Pro Gln Leu Pro Ser Gln Val 
    370                 375                 380                 


Pro Glu His Ser Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu 
385                 390                 395                 400 


Ala Ala Ser Thr Pro Val Thr Ala Ala Ser Asp Gln Lys Gln Glu Glu 
                405                 410                 415     


Lys Pro Lys Pro Asp Pro Val Leu Lys Ser Pro Ser Pro Val Leu Arg 
            420                 425                 430         


Leu Val Leu Ser Gly Glu Lys Lys Glu Gln Glu Gly Gln Thr Ser Glu 
        435                 440                 445             


Thr Thr Ala Ile Val Ser Ile Ala Glu Leu Pro Leu Pro Pro Ser Pro 
    450                 455                 460                 


Thr Thr Val Ser Ser Val Ala Arg Ser Thr Ile Ala Ala Pro Thr Ser 
465                 470                 475                 480 


Ser Ala Leu Ser Ser Gln Pro Ile Phe Thr Thr Ala Ile Asp Asp Arg 
                485                 490                 495     


Cys Glu Leu Ser Ser Pro Arg Glu Asp Thr Ile Pro Ile Pro Ser Leu 
            500                 505                 510         


Thr Ser Cys Thr Glu Thr Ser Asp Pro Leu Pro Thr Asn Glu Asn Asp 
        515                 520                 525             


Asp Asp Ile Cys Lys Lys Pro Cys Ser Val Ala Pro Asn Asp Ile Pro 
    530                 535                 540                 


Leu Val Ser Ser Thr Asn Leu Ile Asn Glu Ile Asn Gly Val Ser Glu 
545                 550                 555                 560 


Lys Leu Ser Ala Thr Glu Ser Ile Val Glu Ile Val Lys Gln Glu Val 
                565                 570                 575     


Leu Pro Leu Thr Leu Glu Leu Glu Ile Leu Glu Asn Pro Pro Glu Glu 
            580                 585                 590         


Met Lys Leu Glu Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr Val Pro 
        595                 600                 605             


Ser Phe Pro Pro Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro His Thr 
    610                 615                 620                 


Pro Val Ile Val Pro Ala Ala Ala Thr Thr Val Ser Ser Pro Ser Ala 
625                 630                 635                 640 


Ala Ile Thr Val Gln Arg Val Leu Glu Glu Asp Glu Ser Ile Arg Thr 
                645                 650                 655     


Cys Leu Ser Glu Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu Val Glu 
            660                 665                 670         


Ala Asp Gly Gln Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser 
        675                 680                 685             


Arg Arg Ser Pro Val Pro Ala Gln Ile Ala Ile Thr Val Pro Lys Thr 
    690                 695                 700                 


Trp Lys Lys Pro Lys Asp Arg Thr Arg Thr Thr Glu Glu Met Leu Glu 
705                 710                 715                 720 


Ala Glu Leu Glu Leu Lys Ala Glu Glu Glu Leu Ser Ile Asp Lys Val 
                725                 730                 735     


Leu Glu Ser Glu Gln Asp Lys Met Ser Gln Gly Phe His Pro Glu Arg 
            740                 745                 750         


Asp Pro Ser Asp Leu Lys Lys Val Lys Ala Val Glu Glu Asn Gly Glu 
        755                 760                 765             


Glu Ala Glu Pro Val Arg Asn Gly Ala Glu Ser Val Ser Glu Gly Glu 
    770                 775                 780                 


Gly Ile Asp Ala Asn Ser Gly Ser Thr Asp Ser Ser Gly Asp Gly Val 
785                 790                 795                 800 


Thr Phe Pro Phe Lys Pro Glu Ser Trp Lys Pro Thr Asp Thr Glu Gly 
                805                 810                 815     


Lys Lys Gln Tyr Asp Arg Glu Phe Leu Leu Asp Phe Gln Phe Met Pro 
            820                 825                 830         


Ala Cys Ile Gln Lys Pro Glu Gly Leu Pro Pro Ile Ser Asp Val Val 
        835                 840                 845             


Leu Asp Lys Ile Asn Gln Pro Lys Leu Pro Met Arg Thr Leu Asp Pro 
    850                 855                 860                 


Arg Ile Leu Pro Arg Gly Pro Asp Phe Thr Pro Ala Phe Ala Asp Phe 
865                 870                 875                 880 


Gly Arg Gln Thr Pro Gly Gly Arg Gly Val Pro Leu Leu Asn Val Gly 
                885                 890                 895     


Ser Arg Arg Ser Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys Ile Ile 
            900                 905                 910         


Thr Val Ser Val Lys Glu Asp Val His Leu Lys Lys Ala Glu Asn Ala 
        915                 920                 925             


Trp Lys Pro Ser Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro Glu Asn 
    930                 935                 940                 


Ile Lys Thr Gln Glu Leu Phe Arg Lys Val Arg Ser Ile Leu Asn Lys 
945                 950                 955                 960 


Leu Thr Pro Gln Met Phe Asn Gln Leu Met Lys Gln Val Ser Gly Leu 
                965                 970                 975     


Thr Val Asp Thr Glu Glu Arg Leu Lys Gly Val Ile Asp Leu Val Phe 
            980                 985                 990         


Glu Lys Ala Ile Asp Glu Pro Ser  Phe Ser Val Ala Tyr  Ala Asn Met 
        995                 1000                 1005             


Cys Arg  Cys Leu Val Thr Leu  Lys Val Pro Met Ala  Asp Lys Pro 
    1010                 1015                 1020             


Gly Asn  Thr Val Asn Phe Arg  Lys Leu Leu Leu Asn  Arg Cys Gln 
    1025                 1030                 1035             


Lys Glu  Phe Glu Lys Asp Lys  Ala Asp Asp Asp Val  Phe Glu Lys 
    1040                 1045                 1050             


Lys Gln  Lys Glu Leu Glu Ala  Ala Ser Ala Pro Glu  Glu Arg Thr 
    1055                 1060                 1065             


Arg Leu  His Asp Glu Leu Glu  Glu Ala Lys Asp Lys  Ala Arg Arg 
    1070                 1075                 1080             


Arg Ser  Ile Gly Asn Ile Lys  Phe Ile Gly Glu Leu  Phe Lys Leu 
    1085                 1090                 1095             


Lys Met  Leu Thr Glu Ala Ile  Met His Asp Cys Val  Val Lys Leu 
    1100                 1105                 1110             


Leu Lys  Asn His Asp Glu Glu  Ser Leu Glu Cys Leu  Cys Arg Leu 
    1115                 1120                 1125             


Leu Thr  Thr Ile Gly Lys Asp  Leu Asp Phe Glu Lys  Ala Lys Pro 
    1130                 1135                 1140             


Arg Met  Asp Gln Tyr Phe Asn  Gln Met Glu Lys Ile  Val Lys Glu 
    1145                 1150                 1155             


Arg Lys  Thr Ser Ser Arg Ile  Arg Phe Met Leu Gln  Asp Val Ile 
    1160                 1165                 1170             


Asp Leu  Arg Leu Cys Asn Trp  Val Ser Arg Arg Ala  Asp Gln Gly 
    1175                 1180                 1185             


Pro Lys  Thr Ile Glu Gln Ile  His Lys Glu Ala Lys  Ile Glu Glu 
    1190                 1195                 1200             


Gln Glu  Glu Gln Arg Lys Val  Gln Gln Leu Met Thr  Lys Glu Lys 
    1205                 1210                 1215             


Arg Arg  Pro Gly Val Gln Arg  Val Asp Glu Gly Gly  Trp Asn Thr 
    1220                 1225                 1230             


Val Gln  Gly Ala Lys Asn Ser  Arg Val Leu Asp Pro  Ser Lys Phe 
    1235                 1240                 1245             


Leu Lys  Ile Thr Lys Pro Thr  Ile Asp Glu Lys Ile  Gln Leu Val 
    1250                 1255                 1260             


Pro Lys  Ala Gln Leu Gly Ser  Trp Gly Lys Gly Ser  Ser Gly Gly 
    1265                 1270                 1275             


Ala Lys  Ala Ser Glu Thr Asp  Ala Leu Arg Ser Ser  Ala Ser Ser 
    1280                 1285                 1290             


Leu Asn  Arg Phe Ser Ala Leu  Gln Pro Pro Ala Pro  Ser Gly Ser 
    1295                 1300                 1305             


Thr Pro  Ser Thr Pro Val Glu  Phe Asp Ser Arg Arg  Thr Leu Thr 
    1310                 1315                 1320             


Ser Arg  Gly Ser Met Gly Arg  Glu Lys Asn Asp Lys  Pro Leu Pro 
    1325                 1330                 1335             


Ser Ala  Thr Ala Arg Pro Asn  Thr Phe Met Arg Gly  Gly Ser Ser 
    1340                 1345                 1350             


Lys Asp  Leu Leu Asp Asn Gln  Ser Gln Glu Glu Gln  Arg Arg Glu 
    1355                 1360                 1365             


Met Leu  Glu Thr Val Lys Gln  Leu Thr Gly Gly Val  Asp Val Glu 
    1370                 1375                 1380             


Arg Asn  Ser Thr Glu Ala Glu  Arg Asn Lys Thr Arg  Glu Ser Ala 
    1385                 1390                 1395             


Lys Pro  Glu Ile Ser Ala Met  Ser Ala His Asp Lys  Ala Ala Leu 
    1400                 1405                 1410             


Ser Glu  Glu Glu Leu Glu Arg  Lys Ser Lys Ser Ile  Ile Asp Glu 
    1415                 1420                 1425             


Phe Leu  His Ile Asn Asp Phe  Lys Glu Ala Met Gln  Cys Val Glu 
    1430                 1435                 1440             


Glu Leu  Asn Ala Gln Gly Leu  Leu His Val Phe Val  Arg Val Gly 
    1445                 1450                 1455             


Val Glu  Ser Thr Leu Glu Arg  Ser Gln Ile Thr Arg  Asp His Met 
    1460                 1465                 1470             


Gly Gln  Leu Leu Tyr Gln Leu  Val Gln Ser Glu Lys  Leu Ser Lys 
    1475                 1480                 1485             


Gln Asp  Phe Phe Lys Gly Phe  Ser Glu Thr Leu Glu  Leu Ala Asp 
    1490                 1495                 1500             


Asp Met  Ala Ile Asp Ile Pro  His Ile Trp Leu Tyr  Leu Ala Glu 
    1505                 1510                 1515             


Leu Val  Thr Pro Met Leu Lys  Glu Gly Gly Ile Ser  Met Arg Glu 
    1520                 1525                 1530             


Leu Thr  Ile Glu Phe Ser Lys  Pro Leu Leu Pro Val  Gly Arg Ala 
    1535                 1540                 1545             


Gly Val  Leu Leu Ser Glu Ile  Leu His Leu Leu Cys  Lys Gln Met 
    1550                 1555                 1560             


Ser His  Lys Lys Val Gly Ala  Leu Trp Arg Glu Ala  Asp Leu Ser 
    1565                 1570                 1575             


Trp Lys  Asp Phe Leu Pro Glu  Gly Glu Asp Val His  Asn Phe Leu 
    1580                 1585                 1590             


Leu Glu  Gln Lys Leu Asp Phe  Ile Glu Ser Asp Ser  Pro Cys Ser 
    1595                 1600                 1605             


Ser Glu  Ala Leu Ser Lys Lys  Glu Leu Ser Ala Glu  Glu Leu Tyr 
    1610                 1615                 1620             


Lys Arg  Leu Glu Lys Leu Ile  Ile Glu Asp Lys Ala  Asn Asp Glu 
    1625                 1630                 1635             


Gln Ile  Phe Asp Trp Val Glu  Ala Asn Leu Asp Glu  Ile Gln Met 
    1640                 1645                 1650             


Ser Ser  Pro Thr Phe Leu Arg  Ala Leu Met Thr Ala  Val Cys Lys 
    1655                 1660                 1665             


Ala Ala  Ile Ile Ala Asp Ser  Ser Thr Phe Arg Val  Asp Thr Ala 
    1670                 1675                 1680             


Val Ile  Lys Gln Arg Val Pro  Ile Leu Leu Lys Tyr  Leu Asp Ser 
    1685                 1690                 1695             


Asp Thr  Glu Lys Glu Leu Gln  Ala Leu Tyr Ala Leu  Gln Ala Ser 
    1700                 1705                 1710             


Ile Val  Lys Leu Asp Gln Pro  Ala Asn Leu Leu Arg  Met Phe Phe 
    1715                 1720                 1725             


Asp Cys  Leu Tyr Asp Glu Glu  Val Ile Ser Glu Asp  Ala Phe Tyr 
    1730                 1735                 1740             


Lys Trp  Glu Ser Ser Lys Asp  Pro Ala Glu Gln Asn  Gly Lys Gly 
    1745                 1750                 1755             


Val Ala  Leu Lys Ser Val Thr  Ala Phe Phe Thr Trp  Leu Arg Glu 
    1760                 1765                 1770             


Ala Glu  Glu Glu Ser Glu Asp  Asn 
    1775                 1780     


<210> 7077
<211> 1585
<212> PRT
<213> Homo sapiens

<400> 7077
Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Phe Gln Arg Pro Gln 
1               5                   10                  15      


Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg 
            20                  25                  30          


Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile 
        35                  40                  45              


Met Met Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro 
    50                  55                  60                  


Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly 
65                  70                  75                  80  


Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr 
                85                  90                  95      


Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe 
            100                 105                 110         


Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr 
        115                 120                 125             


Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile 
    130                 135                 140                 


Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser 
                165                 170                 175     


Thr Pro Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser 
            180                 185                 190         


Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr 
        195                 200                 205             


Pro Val Thr Ala Ala Ser Asp Gln Lys Gln Glu Glu Lys Pro Lys Pro 
    210                 215                 220                 


Asp Pro Val Leu Lys Ser Pro Ser Pro Val Leu Arg Leu Val Leu Ser 
225                 230                 235                 240 


Gly Glu Lys Lys Glu Gln Glu Gly Gln Thr Ser Glu Thr Thr Ala Ile 
                245                 250                 255     


Val Ser Ile Ala Glu Leu Pro Leu Pro Pro Ser Pro Thr Thr Val Ser 
            260                 265                 270         


Ser Val Ala Arg Ser Thr Ile Ala Ala Pro Thr Ser Ser Ala Leu Ser 
        275                 280                 285             


Ser Gln Pro Ile Phe Thr Thr Ala Ile Asp Asp Arg Cys Glu Leu Ser 
    290                 295                 300                 


Ser Pro Arg Glu Asp Thr Ile Pro Ile Pro Ser Leu Thr Ser Cys Thr 
305                 310                 315                 320 


Glu Thr Ser Asp Pro Leu Pro Thr Asn Glu Asn Asp Asp Asp Ile Cys 
                325                 330                 335     


Lys Lys Pro Cys Ser Val Ala Pro Asn Asp Ile Pro Leu Val Ser Ser 
            340                 345                 350         


Thr Asn Leu Ile Asn Glu Ile Asn Gly Val Ser Glu Lys Leu Ser Ala 
        355                 360                 365             


Thr Glu Ser Ile Val Glu Ile Val Lys Gln Glu Val Leu Pro Leu Thr 
    370                 375                 380                 


Leu Glu Leu Glu Ile Leu Glu Asn Pro Pro Glu Glu Met Lys Leu Glu 
385                 390                 395                 400 


Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr Val Pro Ser Phe Pro Pro 
                405                 410                 415     


Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro His Thr Pro Val Ile Val 
            420                 425                 430         


Pro Ala Ala Ala Thr Thr Val Ser Ser Pro Ser Ala Ala Ile Thr Val 
        435                 440                 445             


Gln Arg Val Leu Glu Glu Asp Glu Ser Ile Arg Thr Cys Leu Ser Glu 
    450                 455                 460                 


Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu Val Glu Ala Asp Gly Gln 
465                 470                 475                 480 


Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser Arg Arg Ser Pro 
                485                 490                 495     


Val Pro Ala Gln Ile Ala Ile Thr Val Pro Lys Thr Trp Lys Lys Pro 
            500                 505                 510         


Lys Asp Arg Thr Arg Thr Thr Glu Glu Met Leu Glu Ala Glu Leu Glu 
        515                 520                 525             


Leu Lys Ala Glu Glu Glu Leu Ser Ile Asp Lys Val Leu Glu Ser Glu 
    530                 535                 540                 


Gln Asp Lys Met Ser Gln Gly Phe His Pro Glu Arg Asp Pro Ser Asp 
545                 550                 555                 560 


Leu Lys Lys Val Lys Ala Val Glu Glu Asn Gly Glu Glu Ala Glu Pro 
                565                 570                 575     


Val Arg Asn Gly Ala Glu Ser Val Ser Glu Gly Glu Gly Ile Asp Ala 
            580                 585                 590         


Asn Ser Gly Ser Thr Asp Ser Ser Gly Asp Gly Val Thr Phe Pro Phe 
        595                 600                 605             


Lys Pro Glu Ser Trp Lys Pro Thr Asp Thr Glu Gly Lys Lys Gln Tyr 
    610                 615                 620                 


Asp Arg Glu Phe Leu Leu Asp Phe Gln Phe Met Pro Ala Cys Ile Gln 
625                 630                 635                 640 


Lys Pro Glu Gly Leu Pro Pro Ile Ser Asp Val Val Leu Asp Lys Ile 
                645                 650                 655     


Asn Gln Pro Lys Leu Pro Met Arg Thr Leu Asp Pro Arg Ile Leu Pro 
            660                 665                 670         


Arg Gly Pro Asp Phe Thr Pro Ala Phe Ala Asp Phe Gly Arg Gln Thr 
        675                 680                 685             


Pro Gly Gly Arg Gly Val Pro Leu Leu Asn Val Gly Ser Arg Arg Ser 
    690                 695                 700                 


Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys Ile Ile Thr Val Ser Val 
705                 710                 715                 720 


Lys Glu Asp Val His Leu Lys Lys Ala Glu Asn Ala Trp Lys Pro Ser 
                725                 730                 735     


Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro Glu Asn Ile Lys Thr Gln 
            740                 745                 750         


Glu Leu Phe Arg Lys Val Arg Ser Ile Leu Asn Lys Leu Thr Pro Gln 
        755                 760                 765             


Met Phe Asn Gln Leu Met Lys Gln Val Ser Gly Leu Thr Val Asp Thr 
    770                 775                 780                 


Glu Glu Arg Leu Lys Gly Val Ile Asp Leu Val Phe Glu Lys Ala Ile 
785                 790                 795                 800 


Asp Glu Pro Ser Phe Ser Val Ala Tyr Ala Asn Met Cys Arg Cys Leu 
                805                 810                 815     


Val Thr Leu Lys Val Pro Met Ala Asp Lys Pro Gly Asn Thr Val Asn 
            820                 825                 830         


Phe Arg Lys Leu Leu Leu Asn Arg Cys Gln Lys Glu Phe Glu Lys Asp 
        835                 840                 845             


Lys Ala Asp Asp Asp Val Phe Glu Lys Lys Gln Lys Glu Leu Glu Ala 
    850                 855                 860                 


Ala Ser Ala Pro Glu Glu Arg Thr Arg Leu His Asp Glu Leu Glu Glu 
865                 870                 875                 880 


Ala Lys Asp Lys Ala Arg Arg Arg Ser Ile Gly Asn Ile Lys Phe Ile 
                885                 890                 895     


Gly Glu Leu Phe Lys Leu Lys Met Leu Thr Glu Ala Ile Met His Asp 
            900                 905                 910         


Cys Val Val Lys Leu Leu Lys Asn His Asp Glu Glu Ser Leu Glu Cys 
        915                 920                 925             


Leu Cys Arg Leu Leu Thr Thr Ile Gly Lys Asp Leu Asp Phe Glu Lys 
    930                 935                 940                 


Ala Lys Pro Arg Met Asp Gln Tyr Phe Asn Gln Met Glu Lys Ile Val 
945                 950                 955                 960 


Lys Glu Arg Lys Thr Ser Ser Arg Ile Arg Phe Met Leu Gln Asp Val 
                965                 970                 975     


Ile Asp Leu Arg Leu Cys Asn Trp Val Ser Arg Arg Ala Asp Gln Gly 
            980                 985                 990         


Pro Lys Thr Ile Glu Gln Ile His  Lys Glu Ala Lys Ile  Glu Glu Gln 
        995                 1000                 1005             


Glu Glu  Gln Arg Lys Val Gln  Gln Leu Met Thr Lys  Glu Lys Arg 
    1010                 1015                 1020             


Arg Pro  Gly Val Gln Arg Val  Asp Glu Gly Gly Trp  Asn Thr Val 
    1025                 1030                 1035             


Gln Gly  Ala Lys Asn Ser Arg  Val Leu Asp Pro Ser  Lys Phe Leu 
    1040                 1045                 1050             


Lys Ile  Thr Lys Pro Thr Ile  Asp Glu Lys Ile Gln  Leu Val Pro 
    1055                 1060                 1065             


Lys Ala  Gln Leu Gly Ser Trp  Gly Lys Gly Ser Ser  Gly Gly Ala 
    1070                 1075                 1080             


Lys Ala  Ser Glu Thr Asp Ala  Leu Arg Ser Ser Ala  Ser Ser Leu 
    1085                 1090                 1095             


Asn Arg  Phe Ser Ala Leu Gln  Pro Pro Ala Pro Ser  Gly Ser Thr 
    1100                 1105                 1110             


Pro Ser  Thr Pro Val Glu Phe  Asp Ser Arg Arg Thr  Leu Thr Ser 
    1115                 1120                 1125             


Arg Gly  Ser Met Gly Arg Glu  Lys Asn Asp Lys Pro  Leu Pro Ser 
    1130                 1135                 1140             


Ala Thr  Ala Arg Pro Asn Thr  Phe Met Arg Gly Gly  Ser Ser Lys 
    1145                 1150                 1155             


Asp Leu  Leu Asp Asn Gln Ser  Gln Glu Glu Gln Arg  Arg Glu Met 
    1160                 1165                 1170             


Leu Glu  Thr Val Lys Gln Leu  Thr Gly Gly Val Asp  Val Glu Arg 
    1175                 1180                 1185             


Asn Ser  Thr Glu Ala Glu Arg  Asn Lys Thr Arg Glu  Ser Ala Lys 
    1190                 1195                 1200             


Pro Glu  Ile Ser Ala Met Ser  Ala His Asp Lys Ala  Ala Leu Ser 
    1205                 1210                 1215             


Glu Glu  Glu Leu Glu Arg Lys  Ser Lys Ser Ile Ile  Asp Glu Phe 
    1220                 1225                 1230             


Leu His  Ile Asn Asp Phe Lys  Glu Ala Met Gln Cys  Val Glu Glu 
    1235                 1240                 1245             


Leu Asn  Ala Gln Gly Leu Leu  His Val Phe Val Arg  Val Gly Val 
    1250                 1255                 1260             


Glu Ser  Thr Leu Glu Arg Ser  Gln Ile Thr Arg Asp  His Met Gly 
    1265                 1270                 1275             


Gln Leu  Leu Tyr Gln Leu Val  Gln Ser Glu Lys Leu  Ser Lys Gln 
    1280                 1285                 1290             


Asp Phe  Phe Lys Gly Phe Ser  Glu Thr Leu Glu Leu  Ala Asp Asp 
    1295                 1300                 1305             


Met Ala  Ile Asp Ile Pro His  Ile Trp Leu Tyr Leu  Ala Glu Leu 
    1310                 1315                 1320             


Val Thr  Pro Met Leu Lys Glu  Gly Gly Ile Ser Met  Arg Glu Leu 
    1325                 1330                 1335             


Thr Ile  Glu Phe Ser Lys Pro  Leu Leu Pro Val Gly  Arg Ala Gly 
    1340                 1345                 1350             


Val Leu  Leu Ser Glu Ile Leu  His Leu Leu Cys Lys  Gln Met Ser 
    1355                 1360                 1365             


His Lys  Lys Val Gly Ala Leu  Trp Arg Glu Ala Asp  Leu Ser Trp 
    1370                 1375                 1380             


Lys Asp  Phe Leu Pro Glu Gly  Glu Asp Val His Asn  Phe Leu Leu 
    1385                 1390                 1395             


Glu Gln  Lys Leu Asp Phe Ile  Glu Ser Asp Ser Pro  Cys Ser Ser 
    1400                 1405                 1410             


Glu Ala  Leu Ser Lys Lys Glu  Leu Ser Ala Glu Glu  Leu Tyr Lys 
    1415                 1420                 1425             


Arg Leu  Glu Lys Leu Ile Ile  Glu Asp Lys Ala Asn  Asp Glu Gln 
    1430                 1435                 1440             


Ile Phe  Asp Trp Val Glu Ala  Asn Leu Asp Glu Ile  Gln Met Ser 
    1445                 1450                 1455             


Ser Pro  Thr Phe Leu Arg Ala  Leu Met Thr Ala Val  Cys Lys Ala 
    1460                 1465                 1470             


Ala Ile  Ile Ala Asp Ser Ser  Thr Phe Arg Val Asp  Thr Ala Val 
    1475                 1480                 1485             


Ile Lys  Gln Arg Val Pro Ile  Leu Leu Lys Tyr Leu  Asp Ser Asp 
    1490                 1495                 1500             


Thr Glu  Lys Glu Leu Gln Ala  Leu Tyr Ala Leu Gln  Ala Ser Ile 
    1505                 1510                 1515             


Val Lys  Leu Asp Gln Pro Ala  Asn Leu Leu Arg Met  Phe Phe Asp 
    1520                 1525                 1530             


Cys Leu  Tyr Asp Glu Glu Val  Ile Ser Glu Asp Ala  Phe Tyr Lys 
    1535                 1540                 1545             


Trp Glu  Ser Ser Lys Asp Pro  Ala Glu Gln Asn Gly  Lys Gly Val 
    1550                 1555                 1560             


Ala Leu  Lys Ser Val Thr Ala  Phe Phe Thr Trp Leu  Arg Glu Ala 
    1565                 1570                 1575             


Glu Glu  Glu Ser Glu Asp Asn  
    1580                 1585 


<210> 7078
<211> 1028
<212> PRT
<213> Homo sapiens

<400> 7078
Met Ala Ser Glu Ala Val Lys Val Val Val Arg Cys Arg Pro Met Asn 
1               5                   10                  15      


Gln Arg Glu Arg Glu Leu Arg Cys Gln Pro Val Val Thr Val Asp Cys 
            20                  25                  30          


Ala Arg Ala Gln Cys Cys Ile Gln Asn Pro Gly Ala Ala Asp Glu Pro 
        35                  40                  45              


Pro Lys Gln Phe Thr Phe Asp Gly Ala Tyr His Val Asp His Val Thr 
    50                  55                  60                  


Glu Gln Ile Tyr Asn Glu Ile Ala Tyr Pro Leu Val Glu Gly Val Thr 
65                  70                  75                  80  


Glu Gly Tyr Asn Gly Thr Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly 
                85                  90                  95      


Lys Ser Phe Thr Met Gln Gly Leu Pro Asp Pro Pro Ser Gln Arg Gly 
            100                 105                 110         


Ile Ile Pro Arg Ala Phe Glu His Val Phe Glu Ser Val Gln Cys Ala 
        115                 120                 125             


Glu Asn Thr Lys Phe Leu Val Arg Ala Ser Tyr Leu Glu Ile Tyr Asn 
    130                 135                 140                 


Glu Asp Val Arg Asp Leu Leu Gly Ala Asp Thr Lys Gln Lys Leu Glu 
145                 150                 155                 160 


Leu Lys Glu His Pro Glu Lys Gly Val Tyr Val Lys Gly Leu Ser Met 
                165                 170                 175     


His Thr Val His Ser Val Ala Gln Cys Glu His Ile Met Glu Thr Gly 
            180                 185                 190         


Trp Lys Asn Arg Ser Val Gly Tyr Thr Leu Met Asn Lys Asp Ser Ser 
        195                 200                 205             


Arg Ser His Ser Ile Phe Thr Ile Ser Ile Glu Met Ser Ala Val Asp 
    210                 215                 220                 


Glu Arg Gly Lys Asp His Leu Arg Ala Gly Lys Leu Asn Leu Val Asp 
225                 230                 235                 240 


Leu Ala Gly Ser Glu Arg Gln Ser Lys Thr Gly Ala Thr Gly Glu Arg 
                245                 250                 255     


Leu Lys Glu Ala Thr Lys Ile Asn Leu Ser Leu Ser Ala Leu Gly Asn 
            260                 265                 270         


Val Ile Ser Ala Leu Val Asp Gly Arg Cys Lys His Val Pro Tyr Arg 
        275                 280                 285             


Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Thr 
    290                 295                 300                 


Lys Thr Leu Met Val Ala Cys Leu Ser Pro Ala Asp Asn Asn Tyr Asp 
305                 310                 315                 320 


Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asn Arg Ala Lys Asn Ile Arg 
                325                 330                 335     


Asn Lys Pro Arg Ile Asn Glu Asp Pro Lys Asp Ala Leu Leu Arg Glu 
            340                 345                 350         


Tyr Gln Glu Glu Ile Lys Lys Leu Lys Ala Ile Leu Thr Gln Gln Met 
        355                 360                 365             


Ser Pro Ser Ser Leu Ser Ala Leu Leu Ser Arg Gln Val Pro Pro Asp 
    370                 375                 380                 


Pro Val Gln Val Glu Glu Lys Leu Leu Pro Gln Pro Val Ile Gln His 
385                 390                 395                 400 


Asp Val Glu Ala Glu Lys Gln Leu Ile Arg Glu Glu Tyr Glu Glu Arg 
                405                 410                 415     


Leu Ala Arg Leu Lys Ala Asp Tyr Lys Ala Glu Gln Glu Ser Arg Ala 
            420                 425                 430         


Arg Leu Glu Glu Asp Ile Thr Ala Met Arg Asn Ser Tyr Asp Val Arg 
        435                 440                 445             


Leu Ser Thr Leu Glu Glu Asn Leu Arg Lys Glu Thr Glu Ala Val Leu 
    450                 455                 460                 


Gln Val Gly Val Leu Tyr Lys Ala Glu Val Met Ser Arg Ala Glu Phe 
465                 470                 475                 480 


Ala Ser Ser Ala Glu Tyr Pro Pro Ala Phe Gln Tyr Glu Thr Val Val 
                485                 490                 495     


Lys Pro Lys Val Phe Ser Thr Thr Asp Thr Leu Pro Ser Asp Asp Val 
            500                 505                 510         


Ser Lys Thr Gln Val Ser Ser Arg Phe Ala Glu Leu Pro Lys Val Glu 
        515                 520                 525             


Pro Ser Lys Ser Glu Ile Ser Leu Gly Ser Ser Glu Ser Ser Ser Leu 
    530                 535                 540                 


Glu Glu Thr Ser Val Ser Glu Ala Phe Pro Gly Pro Glu Glu Pro Ser 
545                 550                 555                 560 


Asn Val Glu Val Ser Met Pro Thr Glu Glu Ser Arg Ser Arg Tyr Phe 
                565                 570                 575     


Leu Asp Glu Cys Leu Gly Gln Glu Ala Ala Gly His Leu Leu Gly Glu 
            580                 585                 590         


Gln Asn Tyr Leu Pro Gln Glu Glu Pro Gln Glu Val Pro Leu Gln Gly 
        595                 600                 605             


Leu Leu Gly Leu Gln Asp Pro Phe Ala Glu Val Glu Ala Lys Leu Ala 
    610                 615                 620                 


Arg Leu Ser Ser Thr Val Ala Arg Thr Asp Ala Pro Gln Ala Asp Val 
625                 630                 635                 640 


Pro Lys Val Pro Val Gln Val Pro Ala Pro Thr Asp Leu Leu Glu Pro 
                645                 650                 655     


Ser Asp Ala Arg Pro Glu Ala Glu Ala Ala Asp Asp Phe Pro Pro Arg 
            660                 665                 670         


Pro Glu Val Asp Leu Ala Ser Glu Val Ala Leu Glu Val Val Arg Thr 
        675                 680                 685             


Ala Glu Pro Gly Val Trp Leu Glu Ala Gln Ala Pro Val Ala Leu Val 
    690                 695                 700                 


Ala Gln Pro Glu Pro Leu Pro Ala Thr Ala Gly Val Lys Arg Glu Ser 
705                 710                 715                 720 


Val Gly Met Glu Val Ala Val Leu Thr Asp Asp Pro Leu Pro Val Val 
                725                 730                 735     


Asp Gln Gln Gln Val Leu Ala Arg Leu Gln Leu Leu Glu Gln Gln Val 
            740                 745                 750         


Val Gly Gly Glu Gln Ala Lys Asn Lys Asp Leu Lys Glu Lys His Lys 
        755                 760                 765             


Arg Arg Lys Arg Tyr Ala Asp Glu Arg Arg Lys Gln Leu Val Ala Ala 
    770                 775                 780                 


Leu Gln Asn Ser Asp Glu Asp Ser Gly Asp Trp Val Leu Leu Asn Val 
785                 790                 795                 800 


Tyr Asp Ser Ile Gln Glu Glu Val Arg Ala Lys Ser Lys Leu Leu Glu 
                805                 810                 815     


Lys Met Gln Arg Lys Leu Arg Ala Ala Glu Val Glu Ile Lys Asp Leu 
            820                 825                 830         


Gln Ser Glu Phe Gln Leu Glu Lys Ile Asp Tyr Leu Ala Thr Ile Arg 
        835                 840                 845             


Arg Gln Glu Arg Asp Ser Met Leu Leu Gln Gln Leu Leu Glu Gln Val 
    850                 855                 860                 


Gln Pro Leu Ile Arg Arg Asp Cys Asn Tyr Ser Asn Leu Glu Lys Ile 
865                 870                 875                 880 


Leu Arg Glu Ser Cys Trp Asp Glu Asp Asn Gly Phe Trp Lys Ile Pro 
                885                 890                 895     


His Pro Val Ile Thr Lys Thr Ser Leu Pro Val Val Ser Thr Gly Pro 
            900                 905                 910         


Gln Asn Lys Pro Ala Arg Lys Thr Ser Ala Ala Asp Asn Gly Glu Pro 
        915                 920                 925             


Asn Met Glu Asp Asp Arg Tyr Arg Leu Met Leu Ser Arg Ser Asn Ser 
    930                 935                 940                 


Glu Asn Ile Ala Ser Asn Tyr Phe Arg Ser Lys Arg Ala Ser Gln Ile 
945                 950                 955                 960 


Leu Ser Thr Asp Ala Arg Lys Ser Leu Thr His His Asn Ser Pro Pro 
                965                 970                 975     


Gly Leu Ser Cys Pro Leu Ser Asn Asn Ser Ala Ile Pro Pro Thr Gln 
            980                 985                 990         


Ala Pro Glu Met Pro Gln Pro Arg  Pro Phe Arg Leu Glu  Ser Leu Asp 
        995                 1000                 1005             


Ile Pro  Phe Thr Lys Ala Lys  Arg Lys Lys Ser Lys  Ser Asn Phe 
    1010                 1015                 1020             


Gly Ser  Glu Pro Leu 
    1025             


<210> 7079
<211> 306
<212> PRT
<213> Homo sapiens

<400> 7079
Met Arg Gln His Asp Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly 
1               5                   10                  15      


Arg Arg Ser Phe Cys Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser 
            20                  25                  30          


Thr Gln Val Gly Asp Leu Lys Leu Asp Gly Gly Arg Gln Ser Thr Gly 
        35                  40                  45              


Ala Val Ser Leu Lys Glu Ile Ile Gly Leu Glu Gly Val Glu Leu Gly 
    50                  55                  60                  


Ala Asp Gly Lys Thr Val Ser Tyr Thr Gln Phe Leu Leu Pro Thr Asn 
65                  70                  75                  80  


Ala Phe Gly Ala Arg Arg Asn Thr Ile Asp Ser Thr Ser Ser Phe Ser 
                85                  90                  95      


Gln Phe Arg Asn Leu Ser His Arg Ser Leu Ser Ile Gly Arg Ala Ser 
            100                 105                 110         


Gly Thr Gln Gly Ser Leu Asp Thr Gly Ser Asp Leu Gly Asp Phe Met 
        115                 120                 125             


Asp Tyr Asp Pro Asn Leu Leu Asp Asp Pro Gln Trp Pro Cys Gly Lys 
    130                 135                 140                 


His Lys Arg Val Leu Ile Phe Pro Ser Tyr Met Thr Thr Val Ile Asp 
145                 150                 155                 160 


Tyr Val Lys Pro Ser Asp Leu Lys Lys Asp Met Asn Glu Thr Phe Lys 
                165                 170                 175     


Glu Lys Phe Pro His Ile Lys Leu Thr Leu Ser Lys Ile Arg Ser Leu 
            180                 185                 190         


Lys Arg Glu Met Arg Lys Leu Ala Gln Glu Asp Cys Gly Leu Glu Glu 
        195                 200                 205             


Pro Thr Val Ala Met Ala Phe Val Tyr Phe Glu Lys Leu Ala Leu Lys 
    210                 215                 220                 


Gly Lys Leu Asn Lys Gln Asn Arg Lys Leu Cys Ala Gly Ala Cys Val 
225                 230                 235                 240 


Leu Leu Ala Ala Lys Ile Gly Ser Asp Leu Lys Lys His Glu Val Lys 
                245                 250                 255     


His Leu Ile Asp Lys Leu Glu Glu Lys Phe Arg Leu Asn Arg Arg Glu 
            260                 265                 270         


Leu Ile Ala Phe Glu Phe Pro Val Leu Val Ala Leu Glu Phe Ala Leu 
        275                 280                 285             


His Leu Pro Glu His Glu Val Met Pro His Tyr Arg Arg Leu Val Gln 
    290                 295                 300                 


Ser Ser 
305     


<210> 7080
<211> 939
<212> PRT
<213> Homo sapiens

<400> 7080
Met Ala Ala Gln Pro Pro Arg Gly Ile Arg Leu Ser Ala Leu Cys Pro 
1               5                   10                  15      


Lys Phe Leu His Thr Asn Ser Thr Ser His Thr Trp Pro Phe Ser Ala 
            20                  25                  30          


Val Ala Glu Leu Ile Asp Asn Ala Tyr Asp Pro Asp Val Asn Ala Lys 
        35                  40                  45              


Gln Ile Trp Ile Asp Lys Thr Val Ile Asn Asp His Ile Cys Leu Thr 
    50                  55                  60                  


Phe Thr Asp Asn Gly Asn Gly Met Thr Ser Asp Lys Leu His Lys Met 
65                  70                  75                  80  


Leu Ser Phe Gly Phe Ser Asp Lys Val Thr Met Asn Gly His Val Pro 
                85                  90                  95      


Val Gly Leu Tyr Gly Asn Gly Phe Lys Ser Gly Ser Met Arg Leu Gly 
            100                 105                 110         


Lys Asp Ala Ile Val Phe Thr Lys Asn Gly Glu Ser Met Ser Val Gly 
        115                 120                 125             


Leu Leu Ser Gln Thr Tyr Leu Glu Val Ile Lys Ala Glu His Val Val 
    130                 135                 140                 


Val Pro Ile Val Ala Phe Asn Lys His Arg Gln Met Ile Asn Leu Ala 
145                 150                 155                 160 


Glu Ser Lys Ala Ser Leu Ala Ala Ile Leu Glu His Ser Leu Phe Ser 
                165                 170                 175     


Thr Glu Gln Lys Leu Leu Ala Glu Leu Asp Ala Ile Ile Gly Lys Lys 
            180                 185                 190         


Gly Thr Arg Ile Ile Ile Trp Asn Leu Arg Ser Tyr Lys Asn Ala Thr 
        195                 200                 205             


Glu Phe Asp Phe Glu Lys Asp Lys Tyr Asp Ile Arg Ile Pro Glu Asp 
    210                 215                 220                 


Leu Asp Glu Ile Thr Gly Lys Lys Gly Tyr Lys Lys Gln Glu Arg Met 
225                 230                 235                 240 


Asp Gln Ile Ala Pro Glu Ser Asp Tyr Ser Leu Arg Ala Tyr Cys Ser 
                245                 250                 255     


Ile Leu Tyr Leu Lys Pro Arg Met Gln Ile Ile Leu Arg Gly Gln Lys 
            260                 265                 270         


Val Lys Thr Gln Leu Val Ser Lys Ser Leu Ala Tyr Ile Glu Arg Asp 
        275                 280                 285             


Val Tyr Arg Pro Lys Phe Leu Ser Lys Thr Val Arg Ile Thr Phe Gly 
    290                 295                 300                 


Phe Asn Cys Arg Asn Lys Asp His Tyr Gly Ile Met Met Tyr His Arg 
305                 310                 315                 320 


Asn Arg Leu Ile Lys Ala Tyr Glu Lys Val Gly Cys Gln Leu Arg Ala 
                325                 330                 335     


Asn Asn Met Gly Val Gly Val Val Gly Ile Ile Glu Cys Asn Phe Leu 
            340                 345                 350         


Lys Pro Thr His Asn Lys Gln Asp Phe Asp Tyr Thr Asn Glu Tyr Arg 
        355                 360                 365             


Leu Thr Ile Thr Ala Leu Gly Glu Lys Leu Asn Asp Tyr Trp Asn Glu 
    370                 375                 380                 


Met Lys Val Lys Lys Asn Thr Glu Tyr Pro Leu Asn Leu Pro Val Glu 
385                 390                 395                 400 


Asp Ile Gln Lys Arg Pro Asp Gln Thr Trp Val Gln Cys Asp Ala Cys 
                405                 410                 415     


Leu Lys Trp Arg Lys Leu Pro Asp Gly Met Asp Gln Leu Pro Glu Lys 
            420                 425                 430         


Trp Tyr Cys Ser Asn Asn Pro Asp Pro Gln Phe Arg Asn Cys Glu Val 
        435                 440                 445             


Pro Glu Glu Pro Glu Asp Glu Asp Leu Val His Pro Thr Tyr Glu Lys 
    450                 455                 460                 


Thr Tyr Lys Lys Thr Asn Lys Glu Lys Phe Arg Ile Arg Gln Pro Glu 
465                 470                 475                 480 


Met Ile Pro Arg Ile Asn Ala Glu Leu Leu Phe Arg Pro Thr Ala Leu 
                485                 490                 495     


Ser Thr Pro Ser Phe Ser Ser Pro Lys Glu Ser Val Pro Arg Arg His 
            500                 505                 510         


Leu Ser Glu Gly Thr Asn Ser Tyr Ala Thr Arg Leu Leu Asn Asn His 
        515                 520                 525             


Gln Val Pro Pro Gln Ser Glu Pro Glu Ser Asn Ser Leu Lys Arg Arg 
    530                 535                 540                 


Leu Ser Thr Arg Ser Ser Ile Leu Asn Ala Lys Asn Arg Arg Leu Ser 
545                 550                 555                 560 


Ser Gln Phe Glu Asn Ser Val Tyr Lys Gly Asp Asp Asp Asp Glu Asp 
                565                 570                 575     


Val Ile Ile Leu Glu Glu Asn Ser Thr Pro Lys Pro Ala Val Asp His 
            580                 585                 590         


Asp Ile Asp Met Lys Ser Glu Gln Ser His Val Glu Gln Gly Gly Val 
        595                 600                 605             


Gln Val Glu Phe Val Gly Asp Ser Glu Pro Cys Gly Gln Thr Gly Ser 
    610                 615                 620                 


Thr Ser Thr Ser Ser Ser Arg Cys Asp Gln Gly Asn Thr Ala Ala Thr 
625                 630                 635                 640 


Gln Thr Glu Val Pro Ser Leu Val Val Lys Lys Glu Glu Thr Val Glu 
                645                 650                 655     


Asp Glu Ile Asp Val Arg Asn Asp Ala Val Ile Leu Pro Ser Cys Val 
            660                 665                 670         


Glu Ala Glu Ala Lys Ile His Glu Thr Gln Glu Thr Thr Asp Lys Ser 
        675                 680                 685             


Ala Asp Asp Ala Gly Cys Gln Leu Gln Glu Leu Arg Asn Gln Leu Leu 
    690                 695                 700                 


Leu Val Thr Glu Glu Lys Glu Asn Tyr Lys Arg Gln Cys His Met Phe 
705                 710                 715                 720 


Thr Asp Gln Ile Lys Val Leu Gln Gln Arg Ile Leu Glu Met Asn Asp 
                725                 730                 735     


Lys Tyr Val Lys Lys Glu Thr Cys His Gln Ser Thr Glu Thr Asp Ala 
            740                 745                 750         


Val Phe Leu Leu Glu Ser Ile Asn Gly Lys Ser Glu Ser Pro Asp His 
        755                 760                 765             


Met Val Ser Gln Tyr Gln Gln Ala Leu Glu Glu Ile Glu Arg Leu Lys 
    770                 775                 780                 


Lys Gln Cys Ser Ala Leu Gln His Val Lys Ala Glu Cys Ser Gln Cys 
785                 790                 795                 800 


Ser Asn Asn Glu Ser Lys Ser Glu Met Asp Glu Met Ala Val Gln Leu 
                805                 810                 815     


Asp Asp Val Phe Arg Gln Leu Asp Lys Cys Ser Ile Glu Arg Asp Gln 
            820                 825                 830         


Tyr Lys Ser Glu Val Glu Leu Leu Glu Met Glu Lys Ser Gln Ile Arg 
        835                 840                 845             


Ser Gln Cys Glu Glu Leu Lys Thr Glu Val Glu Gln Leu Lys Ser Thr 
    850                 855                 860                 


Asn Gln Gln Thr Ala Thr Asp Val Ser Thr Ser Ser Asn Ile Glu Glu 
865                 870                 875                 880 


Ser Val Asn His Met Asp Gly Glu Ser Leu Lys Leu Arg Ser Leu Arg 
                885                 890                 895     


Val Asn Val Gly Gln Leu Leu Ala Met Ile Val Pro Asp Leu Asp Leu 
            900                 905                 910         


Gln Gln Val Asn Tyr Asp Val Asp Val Val Asp Glu Ile Leu Gly Gln 
        915                 920                 925             


Val Val Glu Gln Met Ser Glu Ile Ser Ser Thr 
    930                 935                 


<210> 7081
<211> 382
<212> PRT
<213> Homo sapiens

<400> 7081
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
            340                 345                 350         


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
        355                 360                 365             


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
    370                 375                 380         


<210> 7082
<211> 1685
<212> PRT
<213> Homo sapiens

<400> 7082
Met Ser Leu Pro Phe Tyr Gln Arg Cys His Gln His Tyr Asp Leu Ser 
1               5                   10                  15      


Tyr Arg Asn Lys Asp Val Arg Ser Thr Val Ser His Tyr Gln Arg Glu 
            20                  25                  30          


Lys Lys Arg Ser Ala Val Tyr Thr Gln Gly Ser Thr Ala Tyr Ser Ser 
        35                  40                  45              


Arg Ser Ser Ala Ala His Arg Arg Glu Ser Glu Ala Phe Arg Arg Ala 
    50                  55                  60                  


Ser Ala Ser Ser Ser Gln Gln Gln Ala Ser Gln His Ala Leu Ser Ser 
65                  70                  75                  80  


Glu Val Ser Arg Lys Ala Ala Ser Ala Tyr Asp Tyr Gly Ser Ser His 
                85                  90                  95      


Gly Leu Thr Asp Ser Ser Leu Leu Leu Asp Asp Tyr Ser Ser Lys Leu 
            100                 105                 110         


Ser Pro Lys Pro Lys Arg Ala Lys His Ser Leu Leu Ser Gly Glu Glu 
        115                 120                 125             


Lys Glu Asn Leu Pro Ser Asp Tyr Met Val Pro Ile Phe Ser Gly Arg 
    130                 135                 140                 


Gln Lys His Val Ser Gly Ile Thr Asp Thr Glu Glu Glu Arg Ile Lys 
145                 150                 155                 160 


Glu Ala Ala Ala Tyr Ile Ala Gln Arg Asn Leu Leu Ala Ser Glu Glu 
                165                 170                 175     


Gly Ile Thr Thr Ser Lys Gln Ser Thr Ala Ser Lys Gln Thr Thr Ala 
            180                 185                 190         


Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser 
        195                 200                 205             


Thr Ala Ser Arg Gln Ser Thr Ala Ser Arg Gln Ser Val Val Ser Lys 
    210                 215                 220                 


Gln Ala Thr Ser Ala Leu Gln Gln Glu Glu Thr Ser Glu Lys Lys Ser 
225                 230                 235                 240 


Arg Lys Val Val Ile Arg Glu Lys Ala Glu Arg Leu Ser Leu Arg Lys 
                245                 250                 255     


Thr Leu Glu Glu Thr Glu Thr Tyr His Ala Lys Leu Asn Glu Asp His 
            260                 265                 270         


Leu Leu His Ala Pro Glu Phe Ile Ile Lys Pro Arg Ser His Thr Val 
        275                 280                 285             


Trp Glu Lys Glu Asn Val Lys Leu His Cys Ser Ile Ala Gly Trp Pro 
    290                 295                 300                 


Glu Pro Arg Val Thr Trp Tyr Lys Asn Gln Val Pro Ile Asn Val His 
305                 310                 315                 320 


Ala Asn Pro Gly Lys Tyr Ile Ile Glu Ser Arg Tyr Gly Met His Thr 
                325                 330                 335     


Leu Glu Ile Asn Gly Cys Asp Phe Glu Asp Thr Ala Gln Tyr Arg Ala 
            340                 345                 350         


Ser Ala Met Asn Val Lys Gly Glu Leu Ser Ala Tyr Ala Ser Val Val 
        355                 360                 365             


Val Lys Arg Tyr Lys Gly Glu Phe Asp Glu Thr Arg Phe His Ala Gly 
    370                 375                 380                 


Ala Ser Thr Met Pro Leu Ser Phe Gly Val Thr Pro Tyr Gly Tyr Ala 
385                 390                 395                 400 


Ser Arg Phe Glu Ile His Phe Asp Asp Lys Phe Asp Val Ser Phe Gly 
                405                 410                 415     


Arg Glu Gly Glu Thr Met Ser Leu Gly Cys Arg Val Val Ile Thr Pro 
            420                 425                 430         


Glu Ile Lys His Phe Gln Pro Glu Ile Gln Trp Tyr Arg Asn Gly Val 
        435                 440                 445             


Pro Leu Ser Pro Ser Lys Trp Val Gln Thr Leu Trp Ser Gly Glu Arg 
    450                 455                 460                 


Ala Thr Leu Thr Phe Ser His Leu Asn Lys Glu Asp Glu Gly Leu Tyr 
465                 470                 475                 480 


Thr Ile Arg Val Arg Met Gly Glu Tyr Tyr Glu Gln Tyr Ser Ala Tyr 
                485                 490                 495     


Val Phe Val Arg Asp Ala Asp Ala Glu Ile Glu Gly Ala Pro Ala Ala 
            500                 505                 510         


Pro Leu Asp Val Lys Cys Leu Glu Ala Asn Lys Asp Tyr Ile Ile Ile 
        515                 520                 525             


Ser Trp Lys Gln Pro Ala Val Asp Gly Gly Ser Pro Ile Leu Gly Tyr 
    530                 535                 540                 


Phe Ile Asp Lys Cys Glu Val Gly Thr Asp Ser Trp Ser Gln Cys Asn 
545                 550                 555                 560 


Asp Thr Pro Val Lys Phe Ala Arg Phe Pro Val Thr Gly Leu Ile Glu 
                565                 570                 575     


Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Lys Met Gly Ile 
            580                 585                 590         


Gly Phe Pro Ser Arg Val Ser Glu Pro Val Ala Ala Leu Asp Pro Ala 
        595                 600                 605             


Glu Lys Ala Arg Leu Lys Ser Arg Pro Ser Ala Pro Trp Thr Gly Gln 
    610                 615                 620                 


Ile Ile Val Thr Glu Glu Glu Pro Ser Glu Gly Ile Val Pro Gly Pro 
625                 630                 635                 640 


Pro Thr Asp Leu Ser Val Thr Glu Ala Thr Arg Ser Tyr Val Val Leu 
                645                 650                 655     


Ser Trp Lys Pro Pro Gly Gln Arg Gly His Glu Gly Ile Met Tyr Phe 
            660                 665                 670         


Val Glu Lys Cys Glu Ala Gly Thr Glu Asn Trp Gln Arg Val Asn Thr 
        675                 680                 685             


Glu Leu Pro Val Lys Ser Pro Arg Phe Ala Leu Phe Asp Leu Ala Glu 
    690                 695                 700                 


Gly Lys Ser Tyr Cys Phe Arg Val Arg Cys Ser Asn Ser Ala Gly Val 
705                 710                 715                 720 


Gly Glu Pro Ser Glu Ala Thr Glu Val Thr Val Val Gly Asp Lys Leu 
                725                 730                 735     


Asp Ile Pro Lys Ala Pro Gly Lys Ile Ile Pro Ser Arg Asn Thr Asp 
            740                 745                 750         


Thr Ser Val Val Val Ser Trp Glu Glu Ser Lys Asp Ala Lys Glu Leu 
        755                 760                 765             


Val Gly Tyr Tyr Ile Glu Ala Ser Val Ala Gly Ser Gly Lys Trp Glu 
    770                 775                 780                 


Pro Cys Asn Asn Asn Pro Val Lys Gly Ser Arg Phe Thr Cys His Gly 
785                 790                 795                 800 


Leu Val Thr Gly Gln Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ala 
                805                 810                 815     


Ala Gly Leu Ser Glu Tyr Ser Gln Asp Ser Glu Ala Ile Glu Val Lys 
            820                 825                 830         


Ala Ala Ile Gly Gly Gly Val Ser Pro Asp Val Cys Pro Ala Leu Ser 
        835                 840                 845             


Asp Glu Pro Gly Gly Leu Thr Ala Ser Arg Gly Arg Val His Glu Ala 
    850                 855                 860                 


Ser Pro Pro Thr Phe Gln Lys Asp Ala Leu Leu Gly Ser Lys Pro Asn 
865                 870                 875                 880 


Lys Pro Ser Leu Pro Ser Ser Ser Gln Asn Leu Gly Gln Thr Glu Val 
                885                 890                 895     


Ser Lys Val Ser Glu Thr Val Gln Glu Glu Leu Thr Pro Pro Pro Gln 
            900                 905                 910         


Lys Ala Ala Pro Gln Gly Lys Ser Lys Ser Asp Pro Leu Lys Lys Lys 
        915                 920                 925             


Thr Asp Arg Ala Pro Pro Ser Pro Pro Cys Asp Ile Thr Cys Leu Glu 
    930                 935                 940                 


Ser Phe Arg Asp Ser Met Val Leu Gly Trp Lys Gln Pro Asp Lys Ile 
945                 950                 955                 960 


Gly Gly Ala Glu Ile Thr Gly Tyr Tyr Val Asn Tyr Arg Glu Val Ile 
                965                 970                 975     


Asp Gly Val Pro Gly Lys Trp Arg Glu Ala Asn Val Lys Ala Val Ser 
            980                 985                 990         


Glu Glu Ala Tyr Lys Ile Ser Asn  Leu Lys Glu Asn Met  Val Tyr Gln 
        995                 1000                 1005             


Phe Gln  Val Ala Ala Met Asn  Met Ala Gly Leu Gly  Ala Pro Ser 
    1010                 1015                 1020             


Ala Val  Ser Glu Cys Phe Lys  Cys Glu Glu Trp Thr  Ile Ala Val 
    1025                 1030                 1035             


Pro Gly  Pro Pro His Ser Leu  Lys Cys Ser Glu Val  Arg Lys Asp 
    1040                 1045                 1050             


Ser Leu  Val Leu Gln Trp Lys  Pro Pro Val His Ser  Gly Arg Thr 
    1055                 1060                 1065             


Pro Val  Thr Gly Tyr Phe Val  Asp Leu Lys Glu Ala  Lys Ala Lys 
    1070                 1075                 1080             


Glu Asp  Gln Trp Arg Gly Leu  Asn Glu Ala Ala Ile  Lys Asn Val 
    1085                 1090                 1095             


Tyr Leu  Lys Val Arg Gly Leu  Lys Glu Gly Val Ser  Tyr Val Phe 
    1100                 1105                 1110             


Arg Val  Arg Ala Ile Asn Gln  Ala Gly Val Gly Lys  Pro Ser Asp 
    1115                 1120                 1125             


Leu Ala  Gly Pro Val Val Ala  Glu Thr Arg Pro Gly  Thr Lys Glu 
    1130                 1135                 1140             


Val Val  Val Asn Val Asp Asp  Asp Gly Val Ile Ser  Leu Asn Phe 
    1145                 1150                 1155             


Glu Cys  Asp Lys Met Thr Pro  Lys Ser Glu Phe Ser  Trp Ser Lys 
    1160                 1165                 1170             


Asp Tyr  Val Ser Thr Glu Asp  Ser Pro Arg Leu Glu  Val Glu Ser 
    1175                 1180                 1185             


Lys Gly  Asn Lys Thr Lys Met  Thr Phe Lys Asp Leu  Gly Met Asp 
    1190                 1195                 1200             


Asp Leu  Gly Ile Tyr Ser Cys  Asp Val Thr Asp Thr  Asp Gly Ile 
    1205                 1210                 1215             


Ala Ser  Ser Tyr Leu Ile Asp  Glu Glu Glu Leu Lys  Arg Leu Leu 
    1220                 1225                 1230             


Ala Leu  Ser His Glu His Lys  Phe Pro Thr Val Pro  Val Lys Ser 
    1235                 1240                 1245             


Glu Leu  Ala Val Glu Ile Leu  Glu Lys Gly Gln Val  Arg Phe Trp 
    1250                 1255                 1260             


Met Gln  Ala Glu Lys Leu Ser  Gly Asn Ala Lys Val  Asn Tyr Ile 
    1265                 1270                 1275             


Phe Asn  Glu Lys Glu Ile Phe  Glu Gly Pro Lys Tyr  Lys Met His 
    1280                 1285                 1290             


Ile Asp  Arg Asn Thr Gly Ile  Ile Glu Met Phe Met  Glu Lys Leu 
    1295                 1300                 1305             


Gln Asp  Glu Asp Glu Gly Thr  Tyr Thr Phe Gln Leu  Gln Asp Gly 
    1310                 1315                 1320             


Lys Ala  Thr Asn His Ser Thr  Val Val Leu Val Gly  Asp Val Phe 
    1325                 1330                 1335             


Lys Lys  Leu Gln Lys Glu Ala  Glu Phe Gln Arg Gln  Glu Trp Ile 
    1340                 1345                 1350             


Arg Lys  Gln Gly Pro His Phe  Val Glu Tyr Leu Ser  Trp Glu Val 
    1355                 1360                 1365             


Thr Gly  Glu Cys Asn Val Leu  Leu Lys Cys Lys Val  Ala Asn Ile 
    1370                 1375                 1380             


Lys Lys  Glu Thr His Ile Val  Trp Tyr Lys Asp Glu  Arg Glu Ile 
    1385                 1390                 1395             


Ser Val  Asp Glu Lys His Asp  Phe Lys Asp Gly Ile  Cys Thr Leu 
    1400                 1405                 1410             


Leu Ile  Thr Glu Phe Ser Lys  Lys Asp Ala Gly Ile  Tyr Glu Val 
    1415                 1420                 1425             


Ile Leu  Lys Asp Asp Arg Gly  Lys Asp Lys Ser Arg  Leu Lys Leu 
    1430                 1435                 1440             


Val Asp  Glu Ala Phe Lys Glu  Leu Met Met Glu Val  Cys Lys Lys 
    1445                 1450                 1455             


Ile Ala  Leu Ser Ala Thr Asp  Leu Lys Ile Gln Ser  Thr Ala Glu 
    1460                 1465                 1470             


Gly Ile  Gln Leu Tyr Ser Phe  Val Thr Tyr Tyr Val  Glu Asp Leu 
    1475                 1480                 1485             


Lys Val  Asn Trp Ser His Asn  Gly Ser Ala Ile Arg  Tyr Ser Asp 
    1490                 1495                 1500             


Arg Val  Lys Thr Gly Val Thr  Gly Glu Gln Ile Trp  Leu Gln Ile 
    1505                 1510                 1515             


Asn Glu  Pro Thr Pro Asn Asp  Lys Gly Lys Tyr Val  Met Glu Leu 
    1520                 1525                 1530             


Phe Asp  Gly Lys Thr Gly His  Gln Lys Thr Val Asp  Leu Ser Gly 
    1535                 1540                 1545             


Gln Ala  Tyr Asp Glu Ala Tyr  Ala Glu Phe Gln Arg  Leu Lys Lys 
    1550                 1555                 1560             


Ser Leu  Leu Phe Gln Lys Asp  Arg Ala Arg Val Leu  Gly Gly Leu 
    1565                 1570                 1575             


Pro Asp  Val Val Thr Ile Gln  Glu Gly Lys Ala Leu  Asn Leu Thr 
    1580                 1585                 1590             


Cys Asn  Val Trp Gly Asp Pro  Pro Pro Glu Val Ser  Trp Leu Lys 
    1595                 1600                 1605             


Asn Glu  Lys Ala Leu Ala Ser  Asp Asp His Cys Asn  Leu Lys Phe 
    1610                 1615                 1620             


Glu Ala  Gly Arg Thr Ala Tyr  Phe Thr Ile Asn Gly  Val Ser Thr 
    1625                 1630                 1635             


Ala Asp  Ser Gly Lys Tyr Gly  Leu Val Val Lys Asn  Lys Tyr Gly 
    1640                 1645                 1650             


Ser Glu  Thr Ser Asp Phe Thr  Val Ser Val Phe Ile  Pro Glu Glu 
    1655                 1660                 1665             


Glu Ala  Arg Met Ala Ala Leu  Glu Ser Leu Lys Gly  Gly Lys Lys 
    1670                 1675                 1680             


Ala Lys  
    1685 


<210> 7083
<211> 1151
<212> PRT
<213> Homo sapiens

<400> 7083
Met Met Ala Ala Ala Leu Gly Pro Pro Glu Val Ile Ala Gln Leu Glu 
1               5                   10                  15      


Asn Ala Ala Lys Val Leu Met Ala Pro Pro Ser Met Val Asn Asn Glu 
            20                  25                  30          


Gln Arg Gln His Ala Glu His Ile Phe Leu Ser Phe Arg Lys Ser Lys 
        35                  40                  45              


Ser Pro Phe Ala Val Cys Lys His Ile Leu Glu Thr Ser Lys Val Asp 
    50                  55                  60                  


Tyr Val Leu Phe Gln Ala Ala Thr Ala Ile Met Glu Ala Val Val Arg 
65                  70                  75                  80  


Glu Trp Ile Leu Leu Glu Lys Gly Ser Ile Glu Ser Leu Arg Thr Phe 
                85                  90                  95      


Leu Leu Thr Tyr Val Leu Gln Arg Pro Asn Leu Gln Lys Tyr Val Arg 
            100                 105                 110         


Glu Gln Ile Leu Leu Ala Val Ala Val Ile Val Lys Arg Gly Ser Leu 
        115                 120                 125             


Asp Lys Ser Ile Asp Cys Lys Ser Ile Phe His Glu Val Ser Gln Leu 
    130                 135                 140                 


Ile Ser Ser Gly Asn Pro Thr Val Gln Thr Leu Ala Cys Ser Ile Leu 
145                 150                 155                 160 


Thr Ala Leu Leu Ser Glu Phe Ser Ser Ser Ser Lys Thr Ser Asn Ile 
                165                 170                 175     


Gly Leu Ser Met Glu Phe His Gly Asn Cys Lys Arg Val Phe Gln Glu 
            180                 185                 190         


Glu Asp Leu Arg Gln Ile Phe Met Leu Thr Val Glu Val Leu Gln Glu 
        195                 200                 205             


Phe Ser Arg Arg Glu Asn Leu Asn Ala Gln Met Ser Ser Val Phe Gln 
    210                 215                 220                 


Arg Tyr Leu Ala Leu Ala Asn Gln Val Leu Ser Trp Asn Phe Leu Pro 
225                 230                 235                 240 


Pro Lys Leu Gly Arg His Tyr Ile Ala Met Phe Glu Ser Ser Gln Asn 
                245                 250                 255     


Val Leu Leu Lys Pro Thr Glu Ser Trp Arg Glu Thr Leu Leu Asp Ser 
            260                 265                 270         


Arg Val Met Glu Leu Phe Phe Thr Val His Arg Lys Ile Arg Glu Asp 
        275                 280                 285             


Ser Asp Met Ala Gln Asp Ser Leu Gln Cys Leu Ala Gln Leu Ala Ser 
    290                 295                 300                 


Leu His Gly Pro Ile Phe Pro Asp Glu Gly Ser Gln Val Asp Tyr Leu 
305                 310                 315                 320 


Ala His Phe Ile Glu Gly Leu Leu Asn Thr Ile Asn Gly Ile Glu Ile 
                325                 330                 335     


Glu Asp Ser Glu Ala Val Gly Ile Ser Ser Ile Ile Ser Asn Leu Ile 
            340                 345                 350         


Thr Val Phe Pro Arg Asn Val Leu Thr Ala Ile Pro Ser Glu Leu Phe 
        355                 360                 365             


Ser Ser Phe Val Asn Cys Leu Thr His Leu Thr Cys Ser Phe Gly Arg 
    370                 375                 380                 


Ser Ala Ala Leu Glu Glu Val Leu Asp Lys Asp Asp Met Val Tyr Met 
385                 390                 395                 400 


Glu Ala Tyr Asp Lys Leu Leu Glu Ser Trp Leu Thr Leu Val Gln Asp 
                405                 410                 415     


Asp Lys His Phe His Lys Gly Phe Phe Thr Gln His Ala Val Gln Val 
            420                 425                 430         


Phe Asn Ser Tyr Ile Gln Cys His Leu Ala Ala Pro Asp Gly Thr Arg 
        435                 440                 445             


Asn Leu Thr Ala Asn Gly Val Ala Ser Arg Glu Glu Glu Glu Ile Ser 
    450                 455                 460                 


Glu Leu Gln Glu Asp Asp Arg Asp Gln Phe Ser Asp Gln Leu Ala Ser 
465                 470                 475                 480 


Val Gly Met Leu Gly Arg Ile Ala Ala Glu His Cys Ile Pro Leu Leu 
                485                 490                 495     


Thr Ser Leu Leu Glu Glu Arg Val Thr Arg Leu His Gly Gln Leu Gln 
            500                 505                 510         


Arg His Gln Gln Gln Leu Leu Ala Ser Pro Gly Ser Ser Thr Val Asp 
        515                 520                 525             


Asn Lys Met Leu Asp Asp Leu Tyr Glu Asp Ile His Trp Leu Ile Leu 
    530                 535                 540                 


Val Thr Gly Tyr Leu Leu Ala Asp Asp Thr Gln Gly Glu Thr Pro Leu 
545                 550                 555                 560 


Ile Pro Pro Glu Ile Met Glu Tyr Ser Ile Lys His Ser Ser Glu Val 
                565                 570                 575     


Asp Ile Asn Thr Thr Leu Gln Ile Leu Gly Ser Pro Gly Glu Lys Ala 
            580                 585                 590         


Ser Ser Ile Pro Gly Tyr Asn Arg Thr Asp Ser Val Ile Arg Leu Leu 
        595                 600                 605             


Ser Ala Ile Leu Arg Val Ser Glu Val Glu Ser Arg Ala Ile Arg Ala 
    610                 615                 620                 


Asp Leu Thr His Leu Leu Ser Pro Gln Met Gly Lys Asp Ile Val Trp 
625                 630                 635                 640 


Phe Leu Lys Arg Trp Ala Lys Thr Tyr Leu Leu Val Asp Glu Lys Leu 
                645                 650                 655     


Tyr Asp Gln Ile Ser Leu Pro Phe Ser Thr Ala Phe Gly Ala Asp Thr 
            660                 665                 670         


Glu Gly Ser Gln Trp Ile Ile Gly Tyr Leu Leu Gln Lys Val Ile Ser 
        675                 680                 685             


Asn Leu Ser Val Trp Ser Ser Glu Gln Asp Leu Ala Asn Asp Thr Val 
    690                 695                 700                 


Gln Leu Leu Val Thr Leu Val Glu Arg Arg Glu Arg Ala Asn Leu Val 
705                 710                 715                 720 


Ile Gln Cys Glu Asn Trp Trp Asn Leu Ala Lys Gln Phe Ala Ser Arg 
                725                 730                 735     


Ser Pro Pro Leu Asn Phe Leu Ser Ser Pro Val Gln Arg Thr Leu Met 
            740                 745                 750         


Lys Ala Leu Val Leu Gly Gly Phe Ala His Met Asp Thr Glu Thr Lys 
        755                 760                 765             


Gln Gln Tyr Trp Thr Glu Val Leu Gln Pro Leu Gln Gln Arg Phe Leu 
    770                 775                 780                 


Arg Val Ile Asn Gln Glu Asn Phe Gln Gln Met Cys Gln Gln Glu Glu 
785                 790                 795                 800 


Val Lys Gln Glu Ile Thr Ala Thr Leu Glu Ala Leu Cys Gly Ile Ala 
                805                 810                 815     


Glu Ala Thr Gln Ile Asp Asn Val Ala Ile Leu Phe Asn Phe Leu Met 
            820                 825                 830         


Asp Phe Leu Thr Asn Cys Ile Gly Leu Met Glu Val Tyr Lys Asn Thr 
        835                 840                 845             


Pro Glu Thr Val Asn Leu Ile Ile Glu Val Phe Val Glu Val Ala His 
    850                 855                 860                 


Lys Gln Ile Cys Tyr Leu Gly Glu Ser Lys Ala Met Asn Leu Tyr Glu 
865                 870                 875                 880 


Ala Cys Leu Thr Leu Leu Gln Val Tyr Ser Lys Asn Asn Leu Gly Arg 
                885                 890                 895     


Gln Arg Ile Asp Val Thr Ala Glu Glu Glu Gln Tyr Gln Asp Leu Leu 
            900                 905                 910         


Leu Ile Met Glu Leu Leu Thr Asn Leu Leu Ser Lys Glu Phe Ile Asp 
        915                 920                 925             


Phe Ser Asp Thr Asp Glu Val Phe Arg Gly His Glu Pro Gly Gln Ala 
    930                 935                 940                 


Ala Asn Arg Ser Val Ser Ala Ala Asp Val Val Leu Tyr Gly Val Asn 
945                 950                 955                 960 


Leu Ile Leu Pro Leu Met Ser Gln Asp Leu Leu Lys Phe Pro Thr Leu 
                965                 970                 975     


Cys Asn Gln Tyr Tyr Lys Leu Ile Thr Phe Ile Cys Glu Ile Phe Pro 
            980                 985                 990         


Glu Lys Ile Pro Gln Leu Pro Glu  Asp Leu Phe Lys Ser  Leu Met Tyr 
        995                 1000                 1005             


Ser Leu  Glu Leu Gly Met Thr  Ser Met Ser Ser Glu  Val Cys Gln 
    1010                 1015                 1020             


Leu Cys  Leu Glu Ala Leu Thr  Pro Leu Ala Glu Gln  Cys Ala Lys 
    1025                 1030                 1035             


Ala Gln  Glu Thr Asp Ser Pro  Leu Phe Leu Ala Thr  Arg His Phe 
    1040                 1045                 1050             


Leu Lys  Leu Val Phe Asp Met  Leu Val Leu Gln Lys  His Asn Thr 
    1055                 1060                 1065             


Glu Met  Thr Thr Ala Ala Gly  Glu Ala Phe Tyr Thr  Leu Val Cys 
    1070                 1075                 1080             


Leu His  Gln Ala Glu Tyr Ser  Glu Leu Val Glu Thr  Leu Leu Ser 
    1085                 1090                 1095             


Ser Gln  Gln Asp Pro Val Ile  Tyr Gln Arg Leu Ala  Asp Ala Phe 
    1100                 1105                 1110             


Asn Lys  Leu Thr Ala Ser Ser  Thr Pro Pro Thr Leu  Asp Arg Lys 
    1115                 1120                 1125             


Gln Lys  Met Ala Phe Leu Lys  Ser Leu Glu Glu Phe  Met Ala Asn 
    1130                 1135                 1140             


Val Gly  Gly Leu Leu Cys Val  Lys 
    1145                 1150     


<210> 7084
<211> 139
<212> PRT
<213> Homo sapiens

<400> 7084
Met Gly Gly Gly Glu Arg Tyr Asn Ile Pro Ala Pro Gln Ser Arg Asn 
1               5                   10                  15      


Val Ser Lys Asn Gln Gln Gln Leu Asn Arg Gln Lys Thr Lys Glu Gln 
            20                  25                  30          


Asn Ser Gln Met Lys Ile Val His Lys Lys Lys Glu Arg Gly His Gly 
        35                  40                  45              


Tyr Asn Ser Ser Ala Ala Ala Trp Gln Ala Met Gln Asn Gly Gly Lys 
    50                  55                  60                  


Asn Lys Asn Phe Pro Asn Asn Gln Ser Trp Asn Ser Ser Leu Ser Gly 
65                  70                  75                  80  


Pro Arg Leu Leu Phe Lys Ser Gln Ala Asn Gln Asn Tyr Ala Gly Ala 
                85                  90                  95      


Lys Phe Ser Glu Pro Pro Ser Pro Ser Val Leu Pro Lys Pro Pro Ser 
            100                 105                 110         


His Trp Val Pro Val Ser Phe Asn Pro Ser Asp Lys Glu Ile Met Thr 
        115                 120                 125             


Phe Gln Leu Lys Thr Leu Leu Lys Val Gln Val 
    130                 135                 


<210> 7085
<211> 327
<212> PRT
<213> Homo sapiens

<400> 7085
Met Lys Glu Met Leu Ala Lys Asp Leu Glu Glu Ser Gln Gly Gly Lys 
1               5                   10                  15      


Ser Ser Glu Val Leu Ser Ala Thr Glu Leu Arg Val Gln Leu Ala Gln 
            20                  25                  30          


Lys Glu Gln Glu Leu Ala Arg Ala Lys Glu Ala Leu Gln Ala Met Lys 
        35                  40                  45              


Ala Asp Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln 
    50                  55                  60                  


Met Gln Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg 
65                  70                  75                  80  


Asp Phe Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala 
                85                  90                  95      


Val Lys Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp 
            100                 105                 110         


Glu Leu Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu 
        115                 120                 125             


Arg Ser Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala 
    130                 135                 140                 


Glu Leu Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val 
145                 150                 155                 160 


Pro Lys Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu Asn Gly 
                165                 170                 175     


Asn Gln Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala Ala Ile 
            180                 185                 190         


Arg Gln Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His Pro Ala 
        195                 200                 205             


Asp Arg Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln Pro Ser 
    210                 215                 220                 


Val Ile Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser Thr Pro 
225                 230                 235                 240 


Ser Asp Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys Asn Gly 
                245                 250                 255     


Asp Ser Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro Ile Val Gln 
            260                 265                 270         


Ser Leu Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys Glu Lys 
        275                 280                 285             


Met Gly Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly Lys Gln Arg 
    290                 295                 300                 


Lys Ser Leu Asp Pro Gly Leu Phe Asp Gly Thr Ala Pro Asp Tyr Tyr 
305                 310                 315                 320 


Ile Glu Glu Asp Ala Asp Trp 
                325         


<210> 7086
<211> 327
<212> PRT
<213> Homo sapiens

<400> 7086
Met Lys Glu Met Leu Ala Lys Asp Leu Glu Glu Ser Gln Gly Gly Lys 
1               5                   10                  15      


Ser Ser Glu Val Leu Ser Ala Thr Glu Leu Arg Val Gln Leu Ala Gln 
            20                  25                  30          


Lys Glu Gln Glu Leu Ala Arg Ala Lys Glu Ala Leu Gln Ala Met Lys 
        35                  40                  45              


Ala Asp Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln 
    50                  55                  60                  


Met Gln Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg 
65                  70                  75                  80  


Asp Phe Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala 
                85                  90                  95      


Val Lys Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp 
            100                 105                 110         


Glu Leu Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu 
        115                 120                 125             


Arg Ser Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala 
    130                 135                 140                 


Glu Leu Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val 
145                 150                 155                 160 


Pro Lys Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu Asn Gly 
                165                 170                 175     


Asn Gln Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala Ala Ile 
            180                 185                 190         


Arg Gln Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His Pro Ala 
        195                 200                 205             


Asp Arg Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln Pro Ser 
    210                 215                 220                 


Val Ile Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser Thr Pro 
225                 230                 235                 240 


Ser Asp Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys Asn Gly 
                245                 250                 255     


Asp Ser Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro Ile Val Gln 
            260                 265                 270         


Ser Leu Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys Glu Lys 
        275                 280                 285             


Met Gly Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly Lys Gln Arg 
    290                 295                 300                 


Lys Ser Leu Asp Pro Gly Leu Phe Asp Gly Thr Ala Pro Asp Tyr Tyr 
305                 310                 315                 320 


Ile Glu Glu Asp Ala Asp Trp 
                325         


<210> 7087
<211> 202
<212> PRT
<213> Homo sapiens

<400> 7087
Met Asp Glu Gln Ala Leu Leu Gly Leu Asn Pro Asn Ala Asp Ser Asp 
1               5                   10                  15      


Phe Arg Gln Arg Ala Leu Ala Tyr Phe Glu Gln Leu Lys Ile Ser Pro 
            20                  25                  30          


Asp Ala Trp Gln Val Cys Ala Glu Ala Leu Ala Gln Arg Thr Tyr Ser 
        35                  40                  45              


Asp Asp His Val Lys Phe Phe Cys Phe Gln Val Leu Glu His Gln Val 
    50                  55                  60                  


Lys Tyr Lys Tyr Ser Glu Leu Thr Thr Val Gln Gln Gln Leu Ile Arg 
65                  70                  75                  80  


Glu Thr Leu Ile Ser Trp Leu Gln Ala Gln Met Leu Asn Pro Gln Pro 
                85                  90                  95      


Glu Lys Thr Phe Ile Arg Asn Lys Ala Ala Gln Val Phe Ala Leu Leu 
            100                 105                 110         


Phe Val Thr Glu Tyr Leu Thr Lys Trp Pro Lys Phe Phe Phe Asp Ile 
        115                 120                 125             


Leu Ser Val Val Asp Leu Asn Pro Arg Gly Val Asp Leu Tyr Leu Arg 
    130                 135                 140                 


Ile Leu Met Ala Ile Asp Ser Glu Leu Val Asp Arg Asp Val Val His 
145                 150                 155                 160 


Thr Ser Glu Glu Ala Arg Arg Asn Thr Leu Ile Lys Asp Thr Met Arg 
                165                 170                 175     


Glu Gln Cys Ile Pro Asn Leu Val Glu Ser Trp Tyr Gln Ile Leu Gln 
            180                 185                 190         


Asn Tyr Gln Phe Thr Asn Ser Glu Val Thr 
        195                 200         


<210> 7088
<211> 600
<212> PRT
<213> Homo sapiens

<400> 7088
Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Leu Met 
65                  70                  75                  80  


Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val Glu Thr Lys Thr 
                85                  90                  95      


Asp Ala Lys Asn Gly Glu Glu Arg Gly Arg Asp Ala Ser Lys Lys Ala 
            100                 105                 110         


Leu Gly Pro Arg Arg Asp Ser Asp Leu Gly Lys Glu Pro Lys Arg Gly 
        115                 120                 125             


Gly Leu Lys Lys Ser Phe Ser Arg Asp Arg Asp Glu Ala Gly Gly Lys 
    130                 135                 140                 


Ser Gly Glu Lys Pro Lys Glu Glu Lys Ile Ile Arg Gly Ile Asp Lys 
145                 150                 155                 160 


Gly Arg Val Arg Ala Ala Val Asp Lys Lys Glu Ala Gly Lys Asp Gly 
                165                 170                 175     


Arg Gly Glu Glu Arg Ala Val Ala Thr Lys Lys Glu Glu Glu Lys Lys 
            180                 185                 190         


Gly Ser Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp Lys Lys Arg 
        195                 200                 205             


Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys 
    210                 215                 220                 


Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys 
225                 230                 235                 240 


Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys 
                245                 250                 255     


Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys 
            260                 265                 270         


Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr 
        275                 280                 285             


Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu 
    290                 295                 300                 


Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu 
305                 310                 315                 320 


Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn 
                325                 330                 335     


Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr 
            340                 345                 350         


Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn 
        355                 360                 365             


Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys 
    370                 375                 380                 


Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr 
385                 390                 395                 400 


Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr 
                405                 410                 415     


Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys 
            420                 425                 430         


Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu 
        435                 440                 445             


Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr 
    450                 455                 460                 


Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln 
465                 470                 475                 480 


Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu 
                485                 490                 495     


Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser 
            500                 505                 510         


Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly 
        515                 520                 525             


Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro 
    530                 535                 540                 


Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg 
545                 550                 555                 560 


Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp 
                565                 570                 575     


Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys 
            580                 585                 590         


Leu Glu Leu Pro Leu Leu Leu Gln 
        595                 600 


<210> 7089
<211> 66
<212> PRT
<213> Homo sapiens

<400> 7089
Met Ile Gly Thr Thr Glu Val Pro Cys Cys Gly Pro Ser Ala Thr Trp 
1               5                   10                  15      


Ala Leu Arg Trp Ser Asp Gln Ile Thr Leu Pro Ser Leu Pro Trp Thr 
            20                  25                  30          


Met Ser Ser Leu Trp Cys Ile Pro Leu Lys Gly Met Leu Ala Thr Cys 
        35                  40                  45              


Pro Val Ser Leu Leu Glu His Ala Tyr Ser Asn Ala Leu Arg Gly Trp 
    50                  55                  60                  


Lys Pro 
65      


<210> 7090
<211> 706
<212> PRT
<213> Homo sapiens

<400> 7090
Met Ala Thr Ala Asn Phe Gly Lys Ile Gln Ile Gly Ile Tyr Val Glu 
1               5                   10                  15      


Ile Lys Arg Ser Asp Gly Arg Ile His Gln Ala Met Val Thr Ser Leu 
            20                  25                  30          


Asn Glu Asp Asn Glu Ser Val Thr Val Glu Trp Ile Glu Asn Gly Asp 
        35                  40                  45              


Thr Lys Gly Lys Glu Ile Asp Leu Glu Ser Ile Phe Ser Leu Asn Pro 
    50                  55                  60                  


Asp Leu Val Pro Asp Glu Glu Ile Glu Pro Ser Pro Glu Thr Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Ser Ser Ala Lys Val Asn Lys Ile Val Lys Asn Arg Arg 
                85                  90                  95      


Thr Val Ala Ser Ile Lys Asn Asp Pro Pro Ser Arg Asp Asn Arg Val 
            100                 105                 110         


Val Gly Ser Ala Arg Ala Arg Pro Ser Gln Phe Pro Glu Gln Ser Ser 
        115                 120                 125             


Ser Ala Gln Gln Asn Gly Ser Val Ser Asp Ile Ser Pro Val Gln Ala 
    130                 135                 140                 


Ala Lys Lys Glu Phe Gly Pro Pro Ser Arg Arg Lys Ser Asn Cys Val 
145                 150                 155                 160 


Lys Glu Val Glu Lys Leu Gln Glu Lys Arg Glu Lys Arg Arg Leu Gln 
                165                 170                 175     


Gln Gln Glu Leu Arg Glu Lys Arg Ala Gln Asp Val Asp Ala Thr Asn 
            180                 185                 190         


Pro Asn Tyr Glu Ile Met Cys Met Ile Arg Asp Phe Arg Gly Ser Leu 
        195                 200                 205             


Asp Tyr Arg Pro Leu Thr Thr Ala Asp Pro Ile Asp Glu His Arg Ile 
    210                 215                 220                 


Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Lys Glu Thr Gln Met 
225                 230                 235                 240 


Lys Asp Leu Asp Val Ile Thr Ile Pro Ser Lys Asp Val Val Met Val 
                245                 250                 255     


His Glu Pro Lys Gln Lys Val Asp Leu Thr Arg Tyr Leu Glu Asn Gln 
            260                 265                 270         


Thr Phe Arg Phe Asp Tyr Ala Phe Asp Asp Ser Ala Pro Asn Glu Met 
        275                 280                 285             


Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Glu Thr Ile Phe Glu Arg 
    290                 295                 300                 


Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr 
305                 310                 315                 320 


His Thr Met Gly Gly Asp Phe Ser Gly Lys Asn Gln Asp Cys Ser Lys 
                325                 330                 335     


Gly Ile Tyr Ala Leu Ala Ala Arg Asp Val Phe Leu Met Leu Lys Lys 
            340                 345                 350         


Pro Asn Tyr Lys Lys Leu Glu Leu Gln Val Tyr Ala Thr Phe Phe Glu 
        355                 360                 365             


Ile Tyr Ser Gly Lys Val Phe Asp Leu Leu Asn Arg Lys Thr Lys Leu 
    370                 375                 380                 


Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val Gly Leu Gln 
385                 390                 395                 400 


Glu Arg Glu Val Lys Cys Val Glu Asp Val Leu Lys Leu Ile Asp Ile 
                405                 410                 415     


Gly Asn Ser Cys Arg Thr Ser Gly Gln Thr Ser Ala Asn Ala His Ser 
            420                 425                 430         


Ser Arg Ser His Ala Val Phe Gln Ile Ile Leu Arg Arg Lys Gly Lys 
        435                 440                 445             


Leu His Gly Lys Phe Ser Leu Ile Asp Leu Ala Gly Asn Glu Arg Gly 
    450                 455                 460                 


Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Leu Glu Gly Ala Glu 
465                 470                 475                 480 


Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg Ala Leu Gly 
                485                 490                 495     


Arg Asn Lys Pro His Thr Pro Phe Arg Ala Ser Lys Leu Thr Gln Val 
            500                 505                 510         


Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys Met Ile Ala 
        515                 520                 525             


Thr Ile Ser Pro Gly Met Ala Ser Cys Glu Asn Thr Leu Asn Thr Leu 
    530                 535                 540                 


Arg Tyr Ala Asn Arg Val Lys Glu Leu Thr Val Asp Pro Thr Ala Ala 
545                 550                 555                 560 


Gly Asp Val Arg Pro Ile Met His His Pro Pro Asn Gln Ile Asp Asp 
                565                 570                 575     


Leu Glu Thr Gln Trp Gly Val Gly Ser Ser Pro Gln Arg Asp Asp Leu 
            580                 585                 590         


Lys Leu Leu Cys Glu Gln Asn Glu Glu Glu Val Ser Pro Gln Leu Phe 
        595                 600                 605             


Thr Phe His Glu Ala Val Ser Gln Met Val Glu Met Glu Glu Gln Val 
    610                 615                 620                 


Val Glu Asp His Arg Ala Val Phe Gln Glu Ser Ile Arg Trp Leu Glu 
625                 630                 635                 640 


Asp Glu Lys Ala Leu Leu Glu Met Thr Glu Glu Val Asp Tyr Asp Val 
                645                 650                 655     


Asp Ser Tyr Ala Thr Gln Leu Glu Ala Ile Leu Glu Gln Lys Ile Asp 
            660                 665                 670         


Ile Leu Thr Glu Leu Arg Asp Lys Val Lys Ser Phe Arg Ala Ala Leu 
        675                 680                 685             


Gln Glu Glu Glu Gln Ala Ser Lys Gln Ile Asn Pro Lys Arg Pro Arg 
    690                 695                 700                 


Ala Leu 
705     


<210> 7091
<211> 426
<212> PRT
<213> Homo sapiens

<400> 7091
Met Ala His Leu Arg Gly Phe Ala Asn Gln His Ser Arg Val Asp Pro 
1               5                   10                  15      


Glu Glu Leu Phe Thr Lys Leu Asp Arg Ile Gly Lys Gly Ser Phe Gly 
            20                  25                  30          


Glu Val Tyr Lys Gly Ile Asp Asn His Thr Lys Glu Val Val Ala Ile 
        35                  40                  45              


Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln 
    50                  55                  60                  


Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Ile Thr Arg 
65                  70                  75                  80  


Tyr Phe Gly Ser Tyr Leu Lys Ser Thr Lys Leu Trp Ile Ile Met Glu 
                85                  90                  95      


Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly Pro Leu 
            100                 105                 110         


Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu 
        115                 120                 125             


Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys Ala Ala 
    130                 135                 140                 


Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr Phe Val 
                165                 170                 175     


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser Ala Tyr 
            180                 185                 190         


Asp Phe Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
        195                 200                 205             


Ala Lys Gly Glu Pro Pro Asn Ser Asp Leu His Pro Met Arg Val Leu 
    210                 215                 220                 


Phe Leu Ile Pro Lys Asn Ser Pro Pro Thr Leu Glu Gly Gln His Ser 
225                 230                 235                 240 


Lys Pro Phe Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Asp Pro Arg 
                245                 250                 255     


Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile Thr Arg 
            260                 265                 270         


Tyr Thr Lys Lys Thr Ser Phe Leu Thr Glu Leu Ile Asp Arg Tyr Lys 
        275                 280                 285             


Arg Trp Lys Ser Glu Gly His Gly Glu Glu Ser Ser Ser Glu Asp Ser 
    290                 295                 300                 


Asp Ile Asp Gly Glu Ala Glu Asp Gly Glu Gln Gly Pro Ile Trp Thr 
305                 310                 315                 320 


Phe Pro Pro Thr Ile Arg Pro Ser Pro His Ser Lys Leu His Lys Gly 
                325                 330                 335     


Thr Ala Leu His Ser Ser Gln Lys Pro Ala Glu Pro Val Lys Arg Gln 
            340                 345                 350         


Pro Arg Ser Gln Cys Leu Ser Thr Leu Val Arg Pro Val Phe Gly Glu 
        355                 360                 365             


Leu Lys Glu Lys His Lys Gln Ser Gly Gly Ser Val Gly Ala Leu Glu 
    370                 375                 380                 


Glu Leu Glu Asn Ala Phe Ser Leu Ala Glu Glu Ser Cys Pro Gly Ile 
385                 390                 395                 400 


Ser Asp Lys Leu Met Val His Leu Val Glu Arg Val Gln Arg Phe Ser 
                405                 410                 415     


His Asn Arg Asn His Leu Thr Ser Thr Arg 
            420                 425     


<210> 7092
<211> 331
<212> PRT
<213> Homo sapiens

<400> 7092
Met Leu Arg Cys Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg 
1               5                   10                  15      


His Leu Gly Arg Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp 
            20                  25                  30          


Ser Tyr Phe Ser Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr 
        35                  40                  45              


Tyr Ser Ile His Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser 
    50                  55                  60                  


Ile Gly Gln Trp Tyr Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys 
65                  70                  75                  80  


Leu Ala Val Phe Asp Thr Trp Ser Ser Leu Ala Val His Ile Ala Met 
                85                  90                  95      


Asp Asn Thr Val Val Met Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser 
            100                 105                 110         


Val Pro Cys Ala Gly Ala Thr Ala Phe Pro Ala Asp Ser Asp Arg His 
        115                 120                 125             


Cys Asn Gly Phe Pro Ala Gly Ala Glu Val Thr Asn Arg Pro Ser Pro 
    130                 135                 140                 


Trp Arg Pro Leu Val Leu Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp 
145                 150                 155                 160 


Ile Asn Glu Ala Tyr Val Glu Thr Leu Lys His Cys Phe Met Met Pro 
                165                 170                 175     


Gln Ser Leu Gly Val Ile Gly Gly Lys Pro Asn Ser Ala His Tyr Phe 
            180                 185                 190         


Ile Gly Tyr Val Gly Glu Glu Leu Ile Tyr Leu Asp Pro His Thr Thr 
        195                 200                 205             


Gln Pro Ala Val Glu Pro Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser 
    210                 215                 220                 


Phe His Cys Gln His Pro Pro Cys Arg Met Ser Ile Ala Glu Leu Asp 
225                 230                 235                 240 


Pro Ser Ile Ala Val Gly Phe Phe Cys Lys Thr Glu Asp Asp Phe Asn 
                245                 250                 255     


Asp Trp Cys Gln Gln Val Lys Lys Leu Ser Leu Leu Gly Gly Ala Leu 
            260                 265                 270         


Pro Met Phe Glu Leu Val Glu Leu Gln Pro Ser His Leu Ala Cys Pro 
        275                 280                 285             


Asp Val Leu Asn Leu Ser Leu Gly Glu Ser Cys Gln Val Gln Val Gly 
    290                 295                 300                 


Ser Leu Gly Asp Ser Ser Asp Val Glu Arg Leu Glu Arg Phe Phe Asp 
305                 310                 315                 320 


Ser Glu Asp Glu Asp Phe Glu Ile Leu Ser Leu 
                325                 330     


<210> 7093
<211> 486
<212> PRT
<213> Homo sapiens

<400> 7093
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 
145                 150                 155                 160 


Ala Ala Cys Lys Glu Glu Lys Leu Ala Ile Ser Arg Glu Ala Asn Ser 
                165                 170                 175     


Lys Ala Asp Pro Ser Leu Asn Pro Glu Gln Leu Lys Lys Leu Gln Asp 
            180                 185                 190         


Lys Ile Glu Lys Cys Lys Gln Asp Val Leu Lys Thr Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ser Leu Lys Glu Leu Asp Gln Gly Thr Pro Gln Tyr Met Glu 
    210                 215                 220                 


Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys Arg 
225                 230                 235                 240 


Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gln Lys His Leu Asp 
                245                 250                 255     


Leu Ser Asn Val Ala Gly Tyr Lys Ala Ile Tyr His Asp Leu Glu Gln 
            260                 265                 270         


Ser Ile Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala 
        275                 280                 285             


Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp 
    290                 295                 300                 


Ser Ala Asp Leu Asn Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 
305                 310                 315                 320 


Thr Asp Gly Val Thr Leu Thr Gly Ile Asn Gln Thr Gly Asp Gln Ser 
                325                 330                 335     


Leu Pro Ser Lys Pro Ser Ser Thr Leu Asn Val Pro Ser Asn Pro Ala 
            340                 345                 350         


Gln Ser Ala Gln Ser Gln Ser Ser Tyr Asn Pro Phe Glu Asp Glu Asp 
        355                 360                 365             


Asp Thr Gly Ser Thr Val Ser Glu Lys Asp Asp Thr Lys Ala Lys Asn 
    370                 375                 380                 


Val Ser Ser Tyr Glu Lys Thr Gln Ser Tyr Pro Thr Asp Trp Ser Asp 
385                 390                 395                 400 


Asp Glu Ser Asn Asn Pro Phe Ser Ser Thr Asp Ala Asn Gly Asp Ser 
                405                 410                 415     


Asn Pro Phe Asp Asp Asp Ala Thr Ser Gly Thr Glu Val Arg Val Arg 
            420                 425                 430         


Ala Leu Tyr Asp Tyr Glu Gly Gln Glu His Asp Glu Leu Ser Phe Lys 
        435                 440                 445             


Ala Gly Asp Glu Leu Thr Lys Met Glu Asp Glu Asp Glu Gln Gly Trp 
    450                 455                 460                 


Cys Lys Gly Arg Leu Asp Asn Gly Gln Val Gly Leu Tyr Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Glu Ala Ile Gln 
                485     


<210> 7094
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 7094
Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser Glu Gly 
                85                  90                  95      


Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His Thr Pro 
            100                 105                 110         


Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe 
        115                 120                 125             


Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys Asp Gln 
    130                 135                 140                 


His His His Arg Val Glu Gln Leu Thr Leu Asn Gly Leu Leu Gln Ala 
145                 150                 155                 160 


Leu Gln Ser Pro Cys Ile Ile Glu Gly Glu Ser Gly Lys Gly Lys Ser 
                165                 170                 175     


Thr Leu Leu Gln Arg Ile Ala Met Leu Trp Gly Ser Gly Lys Cys Lys 
            180                 185                 190         


Ala Leu Thr Lys Phe Lys Phe Val Phe Phe Leu Arg Leu Ser Arg Ala 
        195                 200                 205             


Gln Gly Gly Leu Phe Glu Thr Leu Cys Asp Gln Leu Leu Asp Ile Pro 
    210                 215                 220                 


Gly Thr Ile Arg Lys Gln Thr Phe Met Ala Met Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Gln Arg Val Leu Phe Leu Leu Asp Gly Tyr Asn Glu Phe Lys Pro Gln 
                245                 250                 255     


Asn Cys Pro Glu Ile Glu Ala Leu Ile Lys Glu Asn His Arg Phe Lys 
            260                 265                 270         


Asn Met Val Ile Val Thr Thr Thr Thr Glu Cys Leu Arg His Ile Arg 
        275                 280                 285             


Gln Phe Gly Ala Leu Thr Ala Glu Val Gly Asp Met Thr Glu Asp Ser 
    290                 295                 300                 


Ala Gln Ala Leu Ile Arg Glu Val Leu Ile Lys Glu Leu Ala Glu Gly 
305                 310                 315                 320 


Leu Leu Leu Gln Ile Gln Lys Ser Arg Cys Leu Arg Asn Leu Met Lys 
                325                 330                 335     


Thr Pro Leu Phe Val Val Ile Thr Cys Ala Ile Gln Met Gly Glu Ser 
            340                 345                 350         


Glu Phe His Ser His Thr Gln Thr Thr Leu Phe His Thr Phe Tyr Asp 
        355                 360                 365             


Leu Leu Ile Gln Lys Asn Lys His Lys His Lys Gly Val Ala Ala Ser 
    370                 375                 380                 


Asp Phe Ile Arg Ser Leu Asp His Cys Gly Asp Leu Ala Leu Glu Gly 
385                 390                 395                 400 


Val Phe Ser His Lys Phe Asp Phe Glu Leu Gln Asp Val Ser Ser Val 
                405                 410                 415     


Asn Glu Asp Val Leu Leu Thr Thr Gly Leu Leu Cys Lys Tyr Thr Ala 
            420                 425                 430         


Gln Arg Phe Lys Pro Lys Tyr Lys Phe Phe His Lys Ser Phe Gln Glu 
        435                 440                 445             


Tyr Thr Ala Gly Arg Arg Leu Ser Ser Leu Leu Thr Ser His Glu Pro 
    450                 455                 460                 


Glu Glu Val Thr Lys Gly Asn Gly Tyr Leu Gln Lys Met Val Ser Ile 
465                 470                 475                 480 


Ser Asp Ile Thr Ser Thr Tyr Ser Ser Leu Leu Arg Tyr Thr Cys Gly 
                485                 490                 495     


Ser Ser Val Glu Ala Thr Arg Ala Val Met Lys His Leu Ala Ala Val 
            500                 505                 510         


Tyr Gln His Gly Cys Leu Leu Gly Leu Ser Ile Ala Lys Arg Pro Leu 
        515                 520                 525             


Trp Arg Gln Glu Ser Leu Gln Ser Val Lys Asn Thr Thr Glu Gln Glu 
    530                 535                 540                 


Ile Leu Lys Ala Ile Asn Ile Asn Ser Phe Val Glu Cys Gly Ile His 
545                 550                 555                 560 


Leu Tyr Gln Glu Ser Thr Ser Lys Ser Ala Leu Ser Gln Glu Phe Glu 
                565                 570                 575     


Ala Phe Phe Gln Gly Lys Ser Leu Tyr Ile Asn Ser Gly Asn Ile Pro 
            580                 585                 590         


Asp Tyr Leu Phe Asp Phe Phe Glu His Leu Pro Asn Cys Ala Ser Ala 
        595                 600                 605             


Leu Asp Phe Ile Lys Leu Asp Phe Tyr Gly Gly Ala Met Ala Ser Trp 
    610                 615                 620                 


Glu Lys Ala Ala Glu Asp Thr Gly Gly Ile His Met Glu Glu Ala Pro 
625                 630                 635                 640 


Glu Thr Tyr Ile Pro Ser Arg Ala Val Ser Leu Phe Phe Asn Trp Lys 
                645                 650                 655     


Gln Glu Phe Arg Thr Leu Glu Val Thr Leu Arg Asp Phe Ser Lys Leu 
            660                 665                 670         


Asn Lys Gln Asp Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr 
        675                 680                 685             


Ser Leu Arg Leu Gln Ile Lys Arg Cys Ala Gly Val Ala Gly Ser Leu 
    690                 695                 700                 


Ser Leu Val Leu Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met Val Glu 
705                 710                 715                 720 


Ala Ser Pro Leu Thr Ile Glu Asp Glu Arg His Ile Thr Ser Val Thr 
                725                 730                 735     


Asn Leu Lys Thr Leu Ser Ile His Asp Leu Gln Asn Gln Arg Leu Pro 
            740                 745                 750         


Gly Gly Leu Thr Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu 
        755                 760                 765             


Ile Met Asp Asn Ile Lys Met Asn Glu Glu Asp Ala Ile Lys Leu Ala 
    770                 775                 780                 


Glu Gly Leu Lys Asn Leu Lys Lys Met Cys Leu Phe His Leu Thr His 
785                 790                 795                 800 


Leu Ser Asp Ile Gly Glu Gly Met Asp Tyr Ile Val Lys Ser Leu Ser 
                805                 810                 815     


Ser Glu Pro Cys Asp Leu Glu Glu Ile Gln Leu Val Ser Cys Cys Leu 
            820                 825                 830         


Ser Ala Asn Ala Val Lys Ile Leu Ala Gln Asn Leu His Asn Leu Val 
        835                 840                 845             


Lys Leu Ser Ile Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly 
    850                 855                 860                 


Asn Glu Ala Leu His Glu Leu Ile Asp Arg Met Asn Val Leu Glu Gln 
865                 870                 875                 880 


Leu Thr Ala Leu Met Leu Pro Trp Gly Cys Asp Val Gln Gly Ser Leu 
                885                 890                 895     


Ser Ser Leu Leu Lys His Leu Glu Glu Val Pro Gln Leu Val Lys Leu 
            900                 905                 910         


Gly Leu Lys Asn Trp Arg Leu Thr Asp Thr Glu Ile Arg Ile Leu Gly 
        915                 920                 925             


Ala Phe Phe Gly Lys Asn Pro Leu Lys Asn Phe Gln Gln Leu Asn Leu 
    930                 935                 940                 


Ala Gly Asn Arg Val Ser Ser Asp Gly Trp Leu Ala Phe Met Gly Val 
945                 950                 955                 960 


Phe Glu Asn Leu Lys Gln Leu Val Phe Phe Asp Phe Ser Thr Lys Glu 
                965                 970                 975     


Phe Leu Pro Asp Pro Ala Leu Val Arg Lys Leu Ser Gln Val Leu Ser 
            980                 985                 990         


Lys Leu Thr Phe Leu Gln Glu Ala  Arg Leu Val Gly Trp  Gln Phe Asp 
        995                 1000                 1005             


Asp Asp  Asp Leu Ser Val Ile  Thr Gly Ala Phe Lys  Leu Val Thr 
    1010                 1015                 1020             


Ala 
    


<210> 7095
<211> 112
<212> PRT
<213> Homo sapiens

<400> 7095
Met Asp Asp Lys Ala Ser Val Gly Lys Ile Ser Val Ser Ser Asp Ser 
1               5                   10                  15      


Val Ser Thr Leu Asn Ser Glu Asp Phe Val Leu Val Ser Arg Gln Gly 
            20                  25                  30          


Asp Glu Thr Pro Ser Thr Asn Asn Gly Ser Asp Asp Glu Lys Thr Gly 
        35                  40                  45              


Leu Lys Ile Val Gly Asn Gly Ser Glu Gln Gln Leu Gln Lys Glu Leu 
    50                  55                  60                  


Ala Asp Val Leu Met Asp Pro Pro Met Asp Asp Gln Pro Gly Glu Lys 
65                  70                  75                  80  


Glu Leu Val Lys Arg Ser Gln Leu Asp Gly Glu Gly Asp Gly Pro Leu 
                85                  90                  95      


Ser Asn Gln Leu Ser Ala Ser Ser Thr Ile Asn Pro Val Pro Leu Val 
            100                 105                 110         


<210> 7096
<211> 146
<212> PRT
<213> Homo sapiens

<400> 7096
Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu Ala Lys 
1               5                   10                  15      


Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp Leu Ile 
            20                  25                  30          


Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn Thr Glu 
        35                  40                  45              


Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys Val Cys 
    50                  55                  60                  


Phe Leu Ala Thr Gly Ala Gly Arg Glu Ser His Cys Ser Ile His Arg 
65                  70                  75                  80  


His Thr Val Val Lys Leu Ala His Thr Tyr Gln Ser Pro Leu Leu Tyr 
                85                  90                  95      


Cys Asp Leu Glu Val Glu Gly Phe Arg Ala Thr Met Ala Gln Arg Leu 
            100                 105                 110         


Val Arg Val Leu Gln Ile Cys Ala Gly His Val Pro Gly Val Ser Ala 
        115                 120                 125             


Leu Asn Leu Leu Ser Leu Leu Arg Ser Ser Glu Gly Pro Ser Leu Glu 
    130                 135                 140                 


Asp Leu 
145     


<210> 7097
<211> 400
<212> PRT
<213> Homo sapiens

<400> 7097
Met Ala Ser Asp Thr Gln Ala Val Pro Asp Val Ser Gly Arg Ser Arg 
1               5                   10                  15      


Ala Arg Arg Tyr Ala Glu Trp Ser Ser Gly Leu Arg Ser Gly Arg Ala 
            20                  25                  30          


Gly Gly Gly Glu Thr Ser Val Glu Arg Arg Arg Thr Cys Ala Phe Asp 
        35                  40                  45              


Thr Leu Glu Ala Phe Leu Ile Met Asp Gly Glu Asp Ile Pro Asp Phe 
    50                  55                  60                  


Ser Ser Leu Lys Glu Glu Thr Ala Tyr Trp Lys Glu Leu Ser Leu Lys 
65                  70                  75                  80  


Tyr Lys Gln Ser Phe Gln Glu Ala Arg Asp Glu Leu Val Glu Phe Gln 
                85                  90                  95      


Glu Gly Ser Arg Glu Leu Glu Ala Glu Leu Glu Ala Gln Leu Val Gln 
            100                 105                 110         


Ala Glu Gln Arg Asn Arg Asp Leu Gln Ala Asp Asn Gln Arg Leu Lys 
        115                 120                 125             


Tyr Glu Val Glu Ala Leu Lys Glu Lys Leu Glu His Gln Tyr Ala Gln 
    130                 135                 140                 


Ser Tyr Lys Gln Val Ser Val Leu Glu Asp Asp Leu Ser Gln Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Glu Gln Leu His Lys Tyr Val Arg Glu Leu Glu Gln Ala 
                165                 170                 175     


Asn Asp Asp Leu Glu Arg Ala Lys Arg Ala Thr Ile Val Ser Leu Glu 
            180                 185                 190         


Asp Phe Glu Gln Arg Leu Asn Gln Ala Ile Glu Arg Asn Ala Phe Leu 
        195                 200                 205             


Glu Ser Glu Leu Asp Glu Lys Glu Ser Leu Leu Val Ser Val Gln Arg 
    210                 215                 220                 


Leu Lys Asp Glu Ala Arg Asp Leu Arg Gln Glu Leu Ala Val Arg Glu 
225                 230                 235                 240 


Arg Gln Gln Glu Val Thr Arg Lys Ser Ala Pro Ser Ser Pro Thr Leu 
                245                 250                 255     


Asp Cys Glu Lys Met Asp Ser Ala Val Gln Ala Ser Leu Ser Leu Pro 
            260                 265                 270         


Ala Thr Pro Val Gly Lys Gly Thr Glu Asn Thr Phe Pro Ser Pro Lys 
        275                 280                 285             


Ala Ile Pro Asn Gly Phe Gly Thr Ser Pro Leu Thr Pro Ser Ala Arg 
    290                 295                 300                 


Ile Ser Ala Leu Asn Ile Val Gly Asp Leu Leu Arg Lys Val Gly Ala 
305                 310                 315                 320 


Leu Glu Ser Lys Leu Ala Ala Cys Arg Asn Phe Ala Lys Asp Gln Ala 
                325                 330                 335     


Ser Arg Lys Ser Tyr Ile Ser Gly Asn Val Asn Cys Gly Val Leu Asn 
            340                 345                 350         


Gly Asn Gly Thr Lys Phe Ser Arg Ser Gly His Thr Ser Phe Phe Asp 
        355                 360                 365             


Lys Gly Ala Val Asn Gly Phe Asp Pro Ala Pro Pro Pro Pro Gly Leu 
    370                 375                 380                 


Gly Ser Ser Arg Pro Ser Ser Ala Pro Gly Met Leu Pro Leu Ser Val 
385                 390                 395                 400 


<210> 7098
<211> 232
<212> PRT
<213> Homo sapiens

<400> 7098
Met Thr Pro Pro Gln Gln Pro Pro Pro Leu Arg Ser Glu Pro Gly Thr 
1               5                   10                  15      


Leu Gly Ser Ala Ala Ser Ser Tyr Ser Pro Leu Gly Leu Asn Gly Val 
            20                  25                  30          


Pro Gly Ser Ile Trp Asp Phe Val Ser Gly Ser Phe Ser Pro Ser Pro 
        35                  40                  45              


Ser Pro Ile Leu Ser Ala Gly Pro Pro Ser Ser Ser Ser Ala Ser Pro 
    50                  55                  60                  


Asn Gly Ala Glu Leu Ala Arg Val Arg Arg Gln Leu Asp Glu Ala Lys 
65                  70                  75                  80  


Arg Lys Ile Arg Gln Trp Glu Glu Ser Trp Gln Gln Val Lys Gln Val 
                85                  90                  95      


Cys Asp Ala Trp Gln Arg Glu Ala Gln Glu Ala Lys Glu Arg Ala Arg 
            100                 105                 110         


Val Ala Asp Ser Asp Arg Gln Leu Ala Leu Gln Lys Lys Glu Glu Val 
        115                 120                 125             


Glu Ala Gln Val Lys Gln Leu Gln Glu Glu Leu Glu Gly Leu Gly Val 
    130                 135                 140                 


Ala Ser Thr Leu Pro Gly Leu Arg Gly Cys Gly Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Pro Leu Pro Lys Leu His Ser Leu Gln Ser Gln Leu Arg Leu Asp Leu 
                165                 170                 175     


Glu Ala Val Asp Gly Val Ile Phe Gln Leu Arg Ala Lys Gln Cys Val 
            180                 185                 190         


Ala Cys Arg Glu Arg Ala His Gly Ala Val Leu Arg Pro Cys Gln His 
        195                 200                 205             


His Ile Leu Cys Glu Pro Cys Ala Ala Thr Ala Pro Glu Cys Pro Tyr 
    210                 215                 220                 


Cys Lys Gly Gln Pro Leu Gln Trp 
225                 230         


<210> 7099
<211> 499
<212> PRT
<213> Homo sapiens

<400> 7099
Met Leu Pro Trp Pro Pro Ala Leu Ala Met Pro Met Pro Thr Glu Gly 
1               5                   10                  15      


Thr Pro Pro Pro Leu Ser Gly Thr Pro Ile Pro Val Pro Ala Tyr Phe 
            20                  25                  30          


Arg His Ala Glu Pro Gly Phe Ser Leu Lys Arg Pro Arg Gly Leu Ser 
        35                  40                  45              


Arg Ser Leu Pro Pro Pro Pro Pro Ala Lys Gly Ser Ile Pro Ile Ser 
    50                  55                  60                  


Arg Leu Phe Pro Pro Arg Thr Pro Gly Trp His Gln Leu Gln Pro Arg 
65                  70                  75                  80  


Arg Val Ser Phe Arg Gly Glu Ala Ser Glu Thr Leu Gln Ser Pro Gly 
                85                  90                  95      


Tyr Asp Pro Ser Arg Pro Glu Ser Phe Phe Gln Gln Ser Phe Gln Arg 
            100                 105                 110         


Leu Ser Arg Leu Gly His Gly Ser Tyr Gly Glu Val Phe Lys Val Arg 
        115                 120                 125             


Ser Lys Glu Asp Gly Arg Leu Tyr Ala Val Lys Arg Ser Met Ser Pro 
    130                 135                 140                 


Phe Arg Gly Pro Lys Asp Arg Ala Arg Lys Leu Ala Glu Val Gly Ser 
145                 150                 155                 160 


His Glu Lys Val Gly Gln His Pro Cys Cys Val Arg Leu Glu Gln Ala 
                165                 170                 175     


Trp Glu Glu Gly Gly Ile Leu Tyr Leu Gln Thr Glu Leu Cys Gly Pro 
            180                 185                 190         


Ser Leu Gln Gln His Cys Glu Ala Trp Gly Ala Ser Leu Pro Glu Ala 
        195                 200                 205             


Gln Val Trp Gly Tyr Leu Arg Asp Thr Leu Leu Ala Leu Ala His Leu 
    210                 215                 220                 


His Ser Gln Gly Leu Val His Leu Asp Val Lys Pro Ala Asn Ile Phe 
225                 230                 235                 240 


Leu Gly Pro Arg Gly Arg Cys Lys Leu Gly Asp Phe Gly Leu Leu Val 
                245                 250                 255     


Glu Leu Gly Thr Ala Gly Ala Gly Glu Val Gln Glu Gly Asp Pro Arg 
            260                 265                 270         


Tyr Met Ala Pro Glu Leu Leu Gln Gly Ser Tyr Gly Thr Ala Ala Asp 
        275                 280                 285             


Val Phe Ser Leu Gly Leu Thr Ile Leu Glu Val Ala Cys Asn Met Glu 
    290                 295                 300                 


Leu Pro His Gly Gly Glu Gly Trp Gln Gln Leu Arg Gln Gly Tyr Leu 
305                 310                 315                 320 


Pro Pro Glu Phe Thr Ala Gly Leu Ser Ser Glu Leu Arg Ser Val Leu 
                325                 330                 335     


Val Met Met Leu Glu Pro Asp Pro Lys Leu Arg Ala Thr Ala Glu Ala 
            340                 345                 350         


Leu Leu Ala Leu Pro Val Leu Arg Gln Pro Arg Ala Trp Gly Val Leu 
        355                 360                 365             


Trp Cys Met Ala Ala Glu Ala Leu Ser Arg Gly Trp Ala Leu Trp Gln 
    370                 375                 380                 


Ala Leu Leu Ala Leu Leu Cys Trp Leu Trp His Gly Leu Ala His Pro 
385                 390                 395                 400 


Ala Ser Trp Leu Gln Pro Leu Gly Pro Pro Ala Thr Pro Pro Gly Ser 
                405                 410                 415     


Pro Pro Cys Ser Leu Leu Leu Asp Ser Ser Leu Ser Ser Asn Trp Asp 
            420                 425                 430         


Asp Asp Ser Leu Gly Pro Ser Leu Ser Pro Glu Ala Val Leu Ala Arg 
        435                 440                 445             


Thr Val Gly Ser Thr Ser Thr Pro Arg Ser Arg Cys Thr Pro Arg Asp 
    450                 455                 460                 


Ala Leu Asp Leu Ser Asp Ile Asn Ser Glu Pro Pro Arg Gly Ser Phe 
465                 470                 475                 480 


Pro Ser Phe Glu Pro Arg Asn Leu Leu Ser Leu Phe Glu Asp Thr Leu 
                485                 490                 495     


Asp Pro Thr 
            


<210> 7100
<211> 1050
<212> PRT
<213> Homo sapiens

<400> 7100
Met Leu Cys Trp Gly Tyr Trp Ser Leu Gly Gln Pro Gly Ile Ser Thr 
1               5                   10                  15      


Asn Leu Gln Gly Ile Val Ala Glu Pro Gln Val Cys Gly Phe Ile Ser 
            20                  25                  30          


Asp Arg Ser Val Lys Glu Val Ala Cys Gly Gly Asn His Ser Val Phe 
        35                  40                  45              


Leu Leu Glu Asp Gly Glu Val Tyr Thr Cys Gly Leu Asn Thr Lys Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Arg Glu Gly Asn Lys Pro Glu Gln Ile Gly Ala 
65                  70                  75                  80  


Leu Ala Asp Gln His Ile Ile His Val Ala Cys Gly Glu Ser His Ser 
                85                  90                  95      


Leu Ala Leu Ser Asp Arg Gly Gln Leu Phe Ser Trp Gly Ala Gly Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Met Thr Thr Glu Asp Ser Val Ala Val Pro 
        115                 120                 125             


Arg Leu Ile Gln Lys Leu Asn Gln Gln Thr Ile Leu Gln Val Ser Cys 
    130                 135                 140                 


Gly Asn Trp His Cys Leu Ala Leu Ala Ala Asp Gly Gln Phe Phe Thr 
145                 150                 155                 160 


Trp Gly Lys Asn Ser His Gly Gln Leu Gly Leu Gly Lys Glu Phe Pro 
                165                 170                 175     


Ser Gln Ala Ser Pro Gln Arg Val Arg Ser Leu Glu Gly Ile Pro Leu 
            180                 185                 190         


Ala Gln Val Ala Ala Gly Gly Ala His Ser Phe Ala Leu Ser Leu Ser 
        195                 200                 205             


Gly Ala Val Phe Gly Trp Gly Met Asn Asn Ala Gly Gln Leu Gly Leu 
    210                 215                 220                 


Ser Asp Glu Lys Asp Arg Glu Ser Pro Cys His Val Lys Leu Leu Arg 
225                 230                 235                 240 


Thr Gln Lys Val Val Tyr Ile Ser Cys Gly Glu Glu His Thr Ala Val 
                245                 250                 255     


Leu Thr Lys Ser Gly Gly Val Phe Thr Phe Gly Ala Gly Ser Cys Gly 
            260                 265                 270         


Gln Leu Gly His Asp Ser Met Asn Asp Glu Val Asn Pro Arg Arg Val 
        275                 280                 285             


Leu Glu Leu Met Gly Ser Glu Val Thr Gln Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Leu Ala Phe Val Pro Ser Ser Gly Leu Ile Tyr Ala Phe Gly 
305                 310                 315                 320 


Cys Gly Ala Arg Gly Gln Leu Gly Thr Gly His Thr Cys Asn Val Lys 
                325                 330                 335     


Cys Pro Ser Pro Val Lys Gly Tyr Trp Ala Ala His Ser Gly Gln Leu 
            340                 345                 350         


Ser Ala Arg Ala Asp Arg Phe Lys Tyr His Ile Val Lys Gln Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Thr Phe Val Leu Cys Ser Lys Tyr Glu Asn Tyr 
    370                 375                 380                 


Ser Pro Ala Val Asp Phe Arg Thr Met Asn Gln Ala His Tyr Thr Ser 
385                 390                 395                 400 


Leu Ile Asn Asp Glu Thr Ile Ala Val Trp Arg Gln Lys Leu Ser Glu 
                405                 410                 415     


His Asn Asn Ala Asn Thr Ile Asn Gly Val Val Gln Ile Leu Ser Ser 
            420                 425                 430         


Ala Ala Cys Trp Asn Gly Ser Phe Leu Glu Lys Lys Ile Asp Glu His 
        435                 440                 445             


Phe Lys Thr Ser Pro Lys Ile Pro Gly Ile Asp Leu Asn Ser Thr Arg 
    450                 455                 460                 


Val Leu Phe Glu Lys Leu Met Asn Ser Gln His Ser Met Ile Leu Glu 
465                 470                 475                 480 


Gln Ile Leu Asn Ser Phe Glu Ser Cys Leu Ile Pro Gln Leu Ser Ser 
                485                 490                 495     


Ser Pro Pro Asp Val Glu Ala Met Arg Ile Tyr Leu Ile Leu Pro Glu 
            500                 505                 510         


Phe Pro Leu Leu Gln Asp Ser Lys Tyr Tyr Ile Thr Leu Thr Ile Pro 
        515                 520                 525             


Leu Ala Met Ala Ile Leu Arg Leu Asp Thr Asn Pro Ser Lys Val Leu 
    530                 535                 540                 


Asp Asn Trp Trp Ser Gln Val Cys Pro Lys Tyr Phe Met Lys Leu Val 
545                 550                 555                 560 


Asn Leu Tyr Lys Gly Ala Val Leu Tyr Leu Leu Arg Gly Arg Lys Thr 
                565                 570                 575     


Phe Leu Ile Pro Val Leu Phe Asn Asn Tyr Ile Thr Ala Ala Leu Lys 
            580                 585                 590         


Leu Leu Glu Lys Leu Tyr Lys Val Asn Leu Lys Val Lys His Val Glu 
        595                 600                 605             


Tyr Asp Thr Phe Tyr Ile Pro Glu Ile Ser Asn Leu Val Asp Ile Gln 
    610                 615                 620                 


Glu Asp Tyr Leu Met Trp Phe Leu His Gln Ala Gly Met Lys Ala Arg 
625                 630                 635                 640 


Pro Ser Ile Ile Gln Asp Thr Val Thr Leu Cys Ser Tyr Pro Phe Ile 
                645                 650                 655     


Phe Asp Ala Gln Ala Lys Thr Lys Met Leu Gln Thr Asp Ala Glu Leu 
            660                 665                 670         


Gln Met Gln Val Ala Val Asn Gly Ala Asn Leu Gln Asn Val Phe Met 
        675                 680                 685             


Leu Leu Thr Leu Glu Pro Leu Leu Ala Arg Ser Pro Phe Leu Val Leu 
    690                 695                 700                 


His Val Arg Arg Asn Asn Leu Val Gly Asp Ala Leu Arg Glu Leu Ser 
705                 710                 715                 720 


Ile His Ser Asp Ile Asp Leu Lys Lys Pro Leu Lys Val Ile Phe Asp 
                725                 730                 735     


Gly Glu Glu Ala Val Asp Ala Gly Gly Val Thr Lys Glu Phe Phe Leu 
            740                 745                 750         


Leu Leu Leu Lys Glu Leu Leu Asn Pro Ile Tyr Gly Met Phe Thr Tyr 
        755                 760                 765             


Tyr Gln Asp Ser Asn Leu Leu Trp Phe Ser Asp Thr Cys Phe Val Glu 
    770                 775                 780                 


His Asn Trp Phe His Leu Ile Gly Ile Thr Cys Gly Leu Ala Ile Tyr 
785                 790                 795                 800 


Asn Ser Thr Val Val Asp Leu His Phe Pro Leu Ala Leu Tyr Lys Lys 
                805                 810                 815     


Leu Leu Asn Val Lys Pro Gly Leu Glu Asp Leu Lys Glu Leu Ser Pro 
            820                 825                 830         


Thr Glu Gly Arg Ser Leu Gln Glu Leu Leu Asp Tyr Pro Gly Glu Asp 
        835                 840                 845             


Val Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Cys Arg Glu Ser Tyr 
    850                 855                 860                 


Gly Val Ile Glu Gln Lys Lys Leu Ile Pro Gly Gly Asp Asn Val Thr 
865                 870                 875                 880 


Val Cys Lys Asp Asn Arg Gln Glu Phe Val Asp Ala Tyr Val Asn Tyr 
                885                 890                 895     


Val Phe Gln Ile Ser Val His Glu Trp Tyr Thr Ala Phe Ser Ser Gly 
            900                 905                 910         


Phe Leu Lys Val Cys Gly Gly Lys Val Leu Glu Leu Phe Gln Pro Ser 
        915                 920                 925             


Glu Leu Arg Ala Met Met Val Gly Asn Ser Asn Tyr Asn Trp Glu Glu 
    930                 935                 940                 


Leu Glu Glu Thr Ala Ile Tyr Lys Gly Asp Tyr Ser Ala Thr His Pro 
945                 950                 955                 960 


Thr Val Lys Leu Phe Trp Glu Thr Phe His Glu Phe Pro Leu Glu Lys 
                965                 970                 975     


Lys Lys Lys Phe Leu Leu Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile 
            980                 985                 990         


Tyr Gly Met Ala Ser Leu Gln Ile  Val Ile Gln Ser Thr  Ala Ser Gly 
        995                 1000                 1005             


Glu Glu  Tyr Leu Pro Val Ala  His Thr Cys Tyr Asn  Leu Leu Asp 
    1010                 1015                 1020             


Leu Pro  Lys Tyr Ser Ser Lys  Glu Ile Leu Ser Ala  Arg Leu Thr 
    1025                 1030                 1035             


Gln Ala  Leu Asp Asn Tyr Glu  Gly Phe Ser Leu Ala  
    1040                 1045                 1050 


<210> 7101
<211> 120
<212> PRT
<213> Homo sapiens

<400> 7101
Met Ser Ile Gly Val Pro Ile Lys Val Leu His Glu Ala Glu Gly His 
1               5                   10                  15      


Ile Val Thr Cys Glu Thr Asn Thr Gly Glu Val Tyr Arg Gly Lys Leu 
            20                  25                  30          


Ile Glu Ala Glu Asp Asn Met Asn Cys Gln Met Ser Asn Ile Thr Val 
        35                  40                  45              


Thr Tyr Arg Asp Gly Arg Val Ala Gln Leu Glu Gln Val Tyr Ile Arg 
    50                  55                  60                  


Gly Ser Lys Ile Arg Phe Leu Ile Leu Pro Asp Met Leu Lys Asn Ala 
65                  70                  75                  80  


Pro Met Leu Lys Ser Met Lys Asn Lys Asn Gln Gly Ser Gly Ala Gly 
                85                  90                  95      


Arg Gly Lys Ala Ala Ile Leu Lys Ala Gln Gly Tyr Leu Ser Ser Leu 
            100                 105                 110         


Glu Trp Val Leu Val His Ile Cys 
        115                 120 


<210> 7102
<211> 393
<212> PRT
<213> Homo sapiens

<400> 7102
Met Glu Glu Asn Asn Leu Gln Cys Ser Ser Val Val Asp Gly Asn Phe 
1               5                   10                  15      


Glu Glu Val Pro Arg Glu Thr Ala Ile Gln Phe Lys Pro Pro Leu Tyr 
            20                  25                  30          


Arg Gln Arg Tyr Gln Phe Val Lys Asn Leu Val Asp Gln His Glu Pro 
        35                  40                  45              


Lys Lys Val Ala Asp Leu Gly Cys Gly Asp Thr Ser Leu Leu Arg Leu 
    50                  55                  60                  


Leu Lys Val Asn Pro Cys Ile Glu Leu Leu Val Gly Val Asp Ile Asn 
65                  70                  75                  80  


Glu Asp Lys Leu Arg Trp Arg Gly Asp Ser Leu Ala Pro Phe Leu Gly 
                85                  90                  95      


Asp Phe Leu Lys Pro Arg Asp Leu Asn Leu Thr Ile Thr Leu Tyr His 
            100                 105                 110         


Gly Ser Val Val Glu Arg Asp Ser Arg Leu Leu Gly Phe Asp Leu Ile 
        115                 120                 125             


Thr Cys Ile Glu Leu Ile Glu His Leu Asp Ser Gly Asp Leu Ala Arg 
    130                 135                 140                 


Phe Pro Glu Val Val Phe Gly Tyr Leu Ser Pro Ser Met Ile Val Ile 
145                 150                 155                 160 


Ser Thr Pro Asn Ser Glu Phe Asn Pro Leu Phe Pro Ser Val Thr Leu 
                165                 170                 175     


Arg Asp Ser Asp His Lys Phe Glu Trp Thr Arg Met Glu Phe Gln Thr 
            180                 185                 190         


Trp Ala Leu Tyr Val Ala Asn Arg Tyr Asp Tyr Ser Val Glu Phe Thr 
        195                 200                 205             


Gly Val Gly Glu Pro Pro Ala Gly Ala Glu Asn Val Gly Tyr Cys Thr 
    210                 215                 220                 


Gln Ile Gly Ile Phe Arg Lys Asn Gly Gly Lys Ala Thr Glu Ser Cys 
225                 230                 235                 240 


Leu Ser Glu Gln His Asp Gln His Val Tyr Lys Ala Val Phe Thr Thr 
                245                 250                 255     


Ser Tyr Pro Ser Leu Gln Gln Glu Arg Phe Phe Lys Leu Val Leu Val 
            260                 265                 270         


Asn Glu Val Ser Gln Gln Val Glu Ser Leu Arg Val Ser His Leu Pro 
        275                 280                 285             


Arg Arg Lys Glu Gln Ala Gly Glu Arg Gly Asp Lys Pro Lys Asp Ile 
    290                 295                 300                 


Gly Gly Ser Lys Ala Pro Val Pro Cys Phe Gly Pro Val Phe Thr Glu 
305                 310                 315                 320 


Val Glu Lys Ala Lys Ile Glu Asn Ser Pro Thr Pro Phe Cys Val Gly 
                325                 330                 335     


Asp Lys Phe Phe Val Pro Leu Gln Arg Leu Leu Ala Tyr Pro Lys Leu 
            340                 345                 350         


Asn Arg Leu Cys Ala Asn Glu Glu Met Met Arg Ser Val Ile Ala Asp 
        355                 360                 365             


Ser Ile Pro Leu Ser Ser Asp Gly Ser Ala Val Val Ala Asp Leu Arg 
    370                 375                 380                 


Asn Tyr Phe Asp Glu Gln Phe Glu Phe 
385                 390             


<210> 7103
<211> 75
<212> PRT
<213> Homo sapiens

<400> 7103
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr 
1               5                   10                  15      


Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val 
            20                  25                  30          


Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His Gly Gln Asn 
        35                  40                  45              


Asn Pro Val Gly Asp Tyr Glu His Ala Asp Asp Gln Ala Glu Glu Asp 
    50                  55                  60                  


Ala Leu Gln Met Ala Val Gly Tyr Phe Glu Lys 
65                  70                  75  


<210> 7104
<211> 331
<212> PRT
<213> Homo sapiens

<400> 7104
Met Ala Phe Val Thr Arg Gln Phe Met Arg Ser Val Ser Ser Ser Ser 
1               5                   10                  15      


Thr Ala Ser Ala Ser Ala Lys Lys Ile Ile Val Lys His Val Thr Val 
            20                  25                  30          


Ile Gly Gly Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ala Ala Ala 
        35                  40                  45              


Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu Asp Ile Leu Ala 
    50                  55                  60                  


Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys Val Ala Lys Lys 
65                  70                  75                  80  


Lys Phe Ala Glu Asn Leu Lys Ala Gly Asp Glu Phe Val Glu Lys Thr 
                85                  90                  95      


Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser Val Val His Ser 
            100                 105                 110         


Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu Lys Val Lys Asn 
        115                 120                 125             


Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu His Thr Ile Phe 
    130                 135                 140                 


Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile Ala Asn Ala Thr 
145                 150                 155                 160 


Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe Asn Pro Val Pro 
                165                 170                 175     


Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met Thr Ser Gln Lys 
            180                 185                 190         


Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu Gly Lys His Pro 
        195                 200                 205             


Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn Arg Leu Leu Val 
    210                 215                 220                 


Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg Asp Phe Gln Thr 
225                 230                 235                 240 


Cys Gly Asp Ser Asn Ser Gly Leu Gly Phe Ser Leu Lys Gly Asp Ala 
                245                 250                 255     


Ser Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala Gly Tyr Pro 
            260                 265                 270         


Met Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp Thr Thr Lys 
        275                 280                 285             


Phe Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn Pro Leu His 
    290                 295                 300                 


Gln Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn Lys Phe Gly 
305                 310                 315                 320 


Lys Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys 
                325                 330     


<210> 7105
<211> 426
<212> PRT
<213> Homo sapiens

<400> 7105
Met Ala His Leu Arg Gly Phe Ala Asn Gln His Ser Arg Val Asp Pro 
1               5                   10                  15      


Glu Glu Leu Phe Thr Lys Leu Asp Arg Ile Gly Lys Gly Ser Phe Gly 
            20                  25                  30          


Glu Val Tyr Lys Gly Ile Asp Asn His Thr Lys Glu Val Val Ala Ile 
        35                  40                  45              


Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln 
    50                  55                  60                  


Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Ile Thr Arg 
65                  70                  75                  80  


Tyr Phe Gly Ser Tyr Leu Lys Ser Thr Lys Leu Trp Ile Ile Met Glu 
                85                  90                  95      


Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly Pro Leu 
            100                 105                 110         


Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu 
        115                 120                 125             


Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys Ala Ala 
    130                 135                 140                 


Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr Phe Val 
                165                 170                 175     


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser Ala Tyr 
            180                 185                 190         


Asp Phe Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
        195                 200                 205             


Ala Lys Gly Glu Pro Pro Asn Ser Asp Leu His Pro Met Arg Val Leu 
    210                 215                 220                 


Phe Leu Ile Pro Lys Asn Ser Pro Pro Thr Leu Glu Gly Gln His Ser 
225                 230                 235                 240 


Lys Pro Phe Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Asp Pro Arg 
                245                 250                 255     


Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile Thr Arg 
            260                 265                 270         


Tyr Thr Lys Lys Thr Ser Phe Leu Thr Glu Leu Ile Asp Arg Tyr Lys 
        275                 280                 285             


Arg Trp Lys Ser Glu Gly His Gly Glu Glu Ser Ser Ser Glu Asp Ser 
    290                 295                 300                 


Asp Ile Asp Gly Glu Ala Glu Asp Gly Glu Gln Gly Pro Ile Trp Thr 
305                 310                 315                 320 


Phe Pro Pro Thr Ile Arg Pro Ser Pro His Ser Lys Leu His Lys Gly 
                325                 330                 335     


Thr Ala Leu His Ser Ser Gln Lys Pro Ala Glu Pro Val Lys Arg Gln 
            340                 345                 350         


Pro Arg Ser Gln Cys Leu Ser Thr Leu Val Arg Pro Val Phe Gly Glu 
        355                 360                 365             


Leu Lys Glu Lys His Lys Gln Ser Gly Gly Ser Val Gly Ala Leu Glu 
    370                 375                 380                 


Glu Leu Glu Asn Ala Phe Ser Leu Ala Glu Glu Ser Cys Pro Gly Ile 
385                 390                 395                 400 


Ser Asp Lys Leu Met Val His Leu Val Glu Arg Val Gln Arg Phe Ser 
                405                 410                 415     


His Asn Arg Asn His Leu Thr Ser Thr Arg 
            420                 425     


<210> 7106
<211> 429
<212> PRT
<213> Homo sapiens

<400> 7106
Met Pro Asn Val Leu Leu Pro Pro Lys Glu Ser Asn Leu Phe Lys Arg 
1               5                   10                  15      


Ile Leu Lys Cys Tyr Glu Gln Lys Gln Tyr Lys Asn Gly Leu Lys Phe 
            20                  25                  30          


Cys Lys Met Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr 
        35                  40                  45              


Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu 
    50                  55                  60                  


Ala Tyr Glu Phe Val Arg Lys Gly Leu Arg Asn Asp Val Lys Ser His 
65                  70                  75                  80  


Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr 
                85                  90                  95      


Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Leu Asp Lys Asp 
            100                 105                 110         


Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg 
        115                 120                 125             


Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg 
    130                 135                 140                 


Pro Thr Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu 
145                 150                 155                 160 


Leu Lys Asp Tyr Asp Met Ala Leu Lys Leu Leu Glu Glu Phe Arg Gln 
                165                 170                 175     


Thr Gln Gln Val Pro Pro Asn Lys Ile Asp Tyr Glu Tyr Ser Glu Leu 
            180                 185                 190         


Ile Leu Tyr Gln Asn Gln Val Met Arg Glu Ala Asp Leu Leu Gln Glu 
        195                 200                 205             


Ser Leu Glu His Ile Glu Met Tyr Glu Lys Gln Ile Cys Asp Lys Leu 
    210                 215                 220                 


Leu Val Glu Glu Ile Lys Gly Glu Ile Leu Leu Lys Leu Gly Arg Leu 
225                 230                 235                 240 


Lys Glu Ala Ser Glu Val Phe Lys Asn Leu Ile Asp Arg Asn Ala Glu 
                245                 250                 255     


Asn Trp Cys Tyr Tyr Glu Gly Leu Glu Lys Ala Leu Gln Ile Ser Thr 
            260                 265                 270         


Leu Glu Glu Arg Leu Gln Ile Tyr Glu Glu Ile Ser Lys Gln His Pro 
        275                 280                 285             


Lys Ala Ile Thr Pro Arg Arg Leu Pro Leu Thr Leu Val Pro Gly Glu 
    290                 295                 300                 


Arg Phe Arg Glu Leu Met Asp Lys Phe Leu Arg Val Asn Phe Ser Lys 
305                 310                 315                 320 


Gly Cys Pro Pro Leu Phe Thr Thr Leu Lys Ser Leu Tyr Tyr Asn Thr 
                325                 330                 335     


Glu Lys Val Ser Ile Ile Gln Glu Leu Val Thr Asn Tyr Glu Ala Ser 
            340                 345                 350         


Leu Lys Thr Cys Asp Phe Phe Ser Pro Tyr Glu Asn Gly Glu Lys Glu 
        355                 360                 365             


Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Phe Leu Ala Gln His Phe 
    370                 375                 380                 


Asp Lys Leu Gly Gln Tyr Ser Leu Ala Leu Asp Tyr Ile Asn Ala Ala 
385                 390                 395                 400 


Ile Ala Ser Thr Pro Thr Leu Ile Glu Leu Phe Tyr Met Lys Ala Lys 
                405                 410                 415     


Ile Tyr Lys Val Lys Ser Glu Ser Cys Phe Leu Ser Ser 
            420                 425                 


<210> 7107
<211> 119
<212> PRT
<213> Homo sapiens

<400> 7107
Met Asp Lys Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe 
1               5                   10                  15      


Arg Gln Ala Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln 
            20                  25                  30          


Lys Thr Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu 
        35                  40                  45              


Ser Leu Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu 
    50                  55                  60                  


Val Asn Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu 
65                  70                  75                  80  


Asp Ser Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp 
                85                  90                  95      


Lys Val Ile Ser Gly Ile Ala Arg Glu Lys Leu Pro Lys Val Asp Ile 
            100                 105                 110         


Ala Ser Ala Glu Ser Ser Ile 
        115                 


<210> 7108
<211> 232
<212> PRT
<213> Homo sapiens

<400> 7108
Met Thr Pro Pro Gln Gln Pro Pro Pro Leu Arg Ser Glu Pro Gly Thr 
1               5                   10                  15      


Leu Gly Ser Ala Ala Ser Ser Tyr Ser Pro Leu Gly Leu Asn Gly Val 
            20                  25                  30          


Pro Gly Ser Ile Trp Asp Phe Val Ser Gly Ser Phe Ser Pro Ser Pro 
        35                  40                  45              


Ser Pro Ile Leu Ser Ala Gly Pro Pro Ser Ser Ser Ser Ala Ser Pro 
    50                  55                  60                  


Asn Gly Ala Glu Leu Ala Arg Val Arg Arg Gln Leu Asp Glu Ala Lys 
65                  70                  75                  80  


Arg Lys Ile Arg Gln Trp Glu Glu Ser Trp Gln Gln Val Lys Gln Val 
                85                  90                  95      


Cys Asp Ala Trp Gln Arg Glu Ala Gln Glu Ala Lys Glu Arg Ala Arg 
            100                 105                 110         


Val Ala Asp Ser Asp Arg Gln Leu Ala Leu Gln Lys Lys Glu Glu Val 
        115                 120                 125             


Glu Ala Gln Val Lys Gln Leu Gln Glu Glu Leu Glu Gly Leu Gly Val 
    130                 135                 140                 


Ala Ser Thr Leu Pro Gly Leu Arg Gly Cys Gly Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Pro Leu Pro Lys Leu His Ser Leu Gln Ser Gln Leu Arg Leu Asp Leu 
                165                 170                 175     


Glu Ala Val Asp Gly Val Ile Phe Gln Leu Arg Ala Lys Gln Cys Val 
            180                 185                 190         


Ala Cys Arg Glu Arg Ala His Gly Ala Val Leu Arg Pro Cys Gln His 
        195                 200                 205             


His Ile Leu Cys Glu Pro Cys Ala Ala Thr Ala Pro Glu Cys Pro Tyr 
    210                 215                 220                 


Cys Lys Gly Gln Pro Leu Gln Trp 
225                 230         


<210> 7109
<211> 486
<212> PRT
<213> Homo sapiens

<400> 7109
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 
145                 150                 155                 160 


Ala Ala Cys Lys Glu Glu Lys Leu Ala Ile Ser Arg Glu Ala Asn Ser 
                165                 170                 175     


Lys Ala Asp Pro Ser Leu Asn Pro Glu Gln Leu Lys Lys Leu Gln Asp 
            180                 185                 190         


Lys Ile Glu Lys Cys Lys Gln Asp Val Leu Lys Thr Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ser Leu Lys Glu Leu Asp Gln Gly Thr Pro Gln Tyr Met Glu 
    210                 215                 220                 


Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys Arg 
225                 230                 235                 240 


Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gln Lys His Leu Asp 
                245                 250                 255     


Leu Ser Asn Val Ala Gly Tyr Lys Ala Ile Tyr His Asp Leu Glu Gln 
            260                 265                 270         


Ser Ile Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala 
        275                 280                 285             


Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp 
    290                 295                 300                 


Ser Ala Asp Leu Asn Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 
305                 310                 315                 320 


Thr Asp Gly Val Thr Leu Thr Gly Ile Asn Gln Thr Gly Asp Gln Ser 
                325                 330                 335     


Leu Pro Ser Lys Pro Ser Ser Thr Leu Asn Val Pro Ser Asn Pro Ala 
            340                 345                 350         


Gln Ser Ala Gln Ser Gln Ser Ser Tyr Asn Pro Phe Glu Asp Glu Asp 
        355                 360                 365             


Asp Thr Gly Ser Thr Val Ser Glu Lys Asp Asp Thr Lys Ala Lys Asn 
    370                 375                 380                 


Val Ser Ser Tyr Glu Lys Thr Gln Ser Tyr Pro Thr Asp Trp Ser Asp 
385                 390                 395                 400 


Asp Glu Ser Asn Asn Pro Phe Ser Ser Thr Asp Ala Asn Gly Asp Ser 
                405                 410                 415     


Asn Pro Phe Asp Asp Asp Ala Thr Ser Gly Thr Glu Val Arg Val Arg 
            420                 425                 430         


Ala Leu Tyr Asp Tyr Glu Gly Gln Glu His Asp Glu Leu Ser Phe Lys 
        435                 440                 445             


Ala Gly Asp Glu Leu Thr Lys Met Glu Asp Glu Asp Glu Gln Gly Trp 
    450                 455                 460                 


Cys Lys Gly Arg Leu Asp Asn Gly Gln Val Gly Leu Tyr Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Glu Ala Ile Gln 
                485     


<210> 7110
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 7110
Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser Glu Gly 
                85                  90                  95      


Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His Thr Pro 
            100                 105                 110         


Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe 
        115                 120                 125             


Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys Asp Gln 
    130                 135                 140                 


His His His Arg Val Glu Gln Leu Thr Leu Asn Gly Leu Leu Gln Ala 
145                 150                 155                 160 


Leu Gln Ser Pro Cys Ile Ile Glu Gly Glu Ser Gly Lys Gly Lys Ser 
                165                 170                 175     


Thr Leu Leu Gln Arg Ile Ala Met Leu Trp Gly Ser Gly Lys Cys Lys 
            180                 185                 190         


Ala Leu Thr Lys Phe Lys Phe Val Phe Phe Leu Arg Leu Ser Arg Ala 
        195                 200                 205             


Gln Gly Gly Leu Phe Glu Thr Leu Cys Asp Gln Leu Leu Asp Ile Pro 
    210                 215                 220                 


Gly Thr Ile Arg Lys Gln Thr Phe Met Ala Met Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Gln Arg Val Leu Phe Leu Leu Asp Gly Tyr Asn Glu Phe Lys Pro Gln 
                245                 250                 255     


Asn Cys Pro Glu Ile Glu Ala Leu Ile Lys Glu Asn His Arg Phe Lys 
            260                 265                 270         


Asn Met Val Ile Val Thr Thr Thr Thr Glu Cys Leu Arg His Ile Arg 
        275                 280                 285             


Gln Phe Gly Ala Leu Thr Ala Glu Val Gly Asp Met Thr Glu Asp Ser 
    290                 295                 300                 


Ala Gln Ala Leu Ile Arg Glu Val Leu Ile Lys Glu Leu Ala Glu Gly 
305                 310                 315                 320 


Leu Leu Leu Gln Ile Gln Lys Ser Arg Cys Leu Arg Asn Leu Met Lys 
                325                 330                 335     


Thr Pro Leu Phe Val Val Ile Thr Cys Ala Ile Gln Met Gly Glu Ser 
            340                 345                 350         


Glu Phe His Ser His Thr Gln Thr Thr Leu Phe His Thr Phe Tyr Asp 
        355                 360                 365             


Leu Leu Ile Gln Lys Asn Lys His Lys His Lys Gly Val Ala Ala Ser 
    370                 375                 380                 


Asp Phe Ile Arg Ser Leu Asp His Cys Gly Asp Leu Ala Leu Glu Gly 
385                 390                 395                 400 


Val Phe Ser His Lys Phe Asp Phe Glu Leu Gln Asp Val Ser Ser Val 
                405                 410                 415     


Asn Glu Asp Val Leu Leu Thr Thr Gly Leu Leu Cys Lys Tyr Thr Ala 
            420                 425                 430         


Gln Arg Phe Lys Pro Lys Tyr Lys Phe Phe His Lys Ser Phe Gln Glu 
        435                 440                 445             


Tyr Thr Ala Gly Arg Arg Leu Ser Ser Leu Leu Thr Ser His Glu Pro 
    450                 455                 460                 


Glu Glu Val Thr Lys Gly Asn Gly Tyr Leu Gln Lys Met Val Ser Ile 
465                 470                 475                 480 


Ser Asp Ile Thr Ser Thr Tyr Ser Ser Leu Leu Arg Tyr Thr Cys Gly 
                485                 490                 495     


Ser Ser Val Glu Ala Thr Arg Ala Val Met Lys His Leu Ala Ala Val 
            500                 505                 510         


Tyr Gln His Gly Cys Leu Leu Gly Leu Ser Ile Ala Lys Arg Pro Leu 
        515                 520                 525             


Trp Arg Gln Glu Ser Leu Gln Ser Val Lys Asn Thr Thr Glu Gln Glu 
    530                 535                 540                 


Ile Leu Lys Ala Ile Asn Ile Asn Ser Phe Val Glu Cys Gly Ile His 
545                 550                 555                 560 


Leu Tyr Gln Glu Ser Thr Ser Lys Ser Ala Leu Ser Gln Glu Phe Glu 
                565                 570                 575     


Ala Phe Phe Gln Gly Lys Ser Leu Tyr Ile Asn Ser Gly Asn Ile Pro 
            580                 585                 590         


Asp Tyr Leu Phe Asp Phe Phe Glu His Leu Pro Asn Cys Ala Ser Ala 
        595                 600                 605             


Leu Asp Phe Ile Lys Leu Asp Phe Tyr Gly Gly Ala Met Ala Ser Trp 
    610                 615                 620                 


Glu Lys Ala Ala Glu Asp Thr Gly Gly Ile His Met Glu Glu Ala Pro 
625                 630                 635                 640 


Glu Thr Tyr Ile Pro Ser Arg Ala Val Ser Leu Phe Phe Asn Trp Lys 
                645                 650                 655     


Gln Glu Phe Arg Thr Leu Glu Val Thr Leu Arg Asp Phe Ser Lys Leu 
            660                 665                 670         


Asn Lys Gln Asp Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr 
        675                 680                 685             


Ser Leu Arg Leu Gln Ile Lys Arg Cys Ala Gly Val Ala Gly Ser Leu 
    690                 695                 700                 


Ser Leu Val Leu Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met Val Glu 
705                 710                 715                 720 


Ala Ser Pro Leu Thr Ile Glu Asp Glu Arg His Ile Thr Ser Val Thr 
                725                 730                 735     


Asn Leu Lys Thr Leu Ser Ile His Asp Leu Gln Asn Gln Arg Leu Pro 
            740                 745                 750         


Gly Gly Leu Thr Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu 
        755                 760                 765             


Ile Met Asp Asn Ile Lys Met Asn Glu Glu Asp Ala Ile Lys Leu Ala 
    770                 775                 780                 


Glu Gly Leu Lys Asn Leu Lys Lys Met Cys Leu Phe His Leu Thr His 
785                 790                 795                 800 


Leu Ser Asp Ile Gly Glu Gly Met Asp Tyr Ile Val Lys Ser Leu Ser 
                805                 810                 815     


Ser Glu Pro Cys Asp Leu Glu Glu Ile Gln Leu Val Ser Cys Cys Leu 
            820                 825                 830         


Ser Ala Asn Ala Val Lys Ile Leu Ala Gln Asn Leu His Asn Leu Val 
        835                 840                 845             


Lys Leu Ser Ile Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly 
    850                 855                 860                 


Asn Glu Ala Leu His Glu Leu Ile Asp Arg Met Asn Val Leu Glu Gln 
865                 870                 875                 880 


Leu Thr Ala Leu Met Leu Pro Trp Gly Cys Asp Val Gln Gly Ser Leu 
                885                 890                 895     


Ser Ser Leu Leu Lys His Leu Glu Glu Val Pro Gln Leu Val Lys Leu 
            900                 905                 910         


Gly Leu Lys Asn Trp Arg Leu Thr Asp Thr Glu Ile Arg Ile Leu Gly 
        915                 920                 925             


Ala Phe Phe Gly Lys Asn Pro Leu Lys Asn Phe Gln Gln Leu Asn Leu 
    930                 935                 940                 


Ala Gly Asn Arg Val Ser Ser Asp Gly Trp Leu Ala Phe Met Gly Val 
945                 950                 955                 960 


Phe Glu Asn Leu Lys Gln Leu Val Phe Phe Asp Phe Ser Thr Lys Glu 
                965                 970                 975     


Phe Leu Pro Asp Pro Ala Leu Val Arg Lys Leu Ser Gln Val Leu Ser 
            980                 985                 990         


Lys Leu Thr Phe Leu Gln Glu Ala  Arg Leu Val Gly Trp  Gln Phe Asp 
        995                 1000                 1005             


Asp Asp  Asp Leu Ser Val Ile  Thr Gly Ala Phe Lys  Leu Val Thr 
    1010                 1015                 1020             


Ala 
    


<210> 7111
<211> 588
<212> PRT
<213> Homo sapiens

<400> 7111
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly His Arg 
    530                 535                 540                 


Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu Val Arg Gly Ser Pro 
545                 550                 555                 560 


Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly Ser Pro Ala Arg Met 
                565                 570                 575     


His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585             


<210> 7112
<211> 221
<212> PRT
<213> Homo sapiens

<400> 7112
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg 
    210                 215                 220     


<210> 7113
<211> 299
<212> PRT
<213> Homo sapiens

<400> 7113
Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly Thr Gly Ala Gln 
1               5                   10                  15      


Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly Thr Phe Lys Val 
            20                  25                  30          


Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala Lys Glu Leu Arg 
        35                  40                  45              


Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp Asp Gln Val Ile 
    50                  55                  60                  


Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe Ile Val Thr Asn 
65                  70                  75                  80  


Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys Gln Gly Lys Leu 
                85                  90                  95      


Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr Val Val Tyr Ser 
            100                 105                 110         


Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg Leu Ala Ala Ala 
        115                 120                 125             


His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe Arg Asp Ile Gly 
    130                 135                 140                 


Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe Glu Asn Leu Leu 
145                 150                 155                 160 


Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys Ser Tyr Leu Leu 
                165                 170                 175     


Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met Ser Val Ser Asp 
            180                 185                 190         


Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro Glu Lys Tyr Val 
        195                 200                 205             


Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr Ala Glu Glu Tyr 
    210                 215                 220                 


Ala Ala Leu Leu Thr Lys His Thr Arg Lys Val Val His Asp Ala Lys 
225                 230                 235                 240 


Met Thr Pro Glu Asp Tyr Glu Lys Leu Gly Phe Pro Gly Ala Arg Asp 
                245                 250                 255     


Leu Ala Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro Asp Arg Asp Ile 
            260                 265                 270         


Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr Leu Asp Gln Trp 
        275                 280                 285             


Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu 
    290                 295                 


<210> 7114
<211> 730
<212> PRT
<213> Homo sapiens

<400> 7114
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala 
    130                 135                 140                 


Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr 
145                 150                 155                 160 


Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp 
                165                 170                 175     


Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys 
            180                 185                 190         


Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys Gln Val Ala Trp Ile 
        195                 200                 205             


Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu Leu Leu Pro Val Cys 
    210                 215                 220                 


Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala 
225                 230                 235                 240 


Glu Asp Asn Lys Tyr Leu Leu Thr Cys Lys Thr Ala Arg Gln Leu Thr 
                245                 250                 255     


Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala Pro Asp Asn Ile Ile 
            260                 265                 270         


Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu Gly Lys Cys Cys 
        275                 280                 285             


Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro Ile Glu Arg Glu Glu 
    290                 295                 300                 


His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro Ser Ile Gln Glu 
305                 310                 315                 320 


Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu Val Gly Asn Met Thr 
                325                 330                 335     


Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu Glu Lys Asp Asn Ser 
            340                 345                 350         


Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu Leu Pro Lys Gly Val 
        355                 360                 365             


Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe Pro Lys Lys Ala Trp 
    370                 375                 380                 


Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu Leu Ile Gln Pro Ser 
385                 390                 395                 400 


Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys Thr Pro Ala Gln Ser 
                405                 410                 415     


Thr His Ser Glu Ala Pro Pro Ser Lys Met Val Leu Arg Ile Pro His 
            420                 425                 430         


Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val Pro Gly Val Pro Pro 
        435                 440                 445             


Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser Pro Ala Ala Leu Pro 
    450                 455                 460                 


Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro Leu Ser Glu Ser Gln 
465                 470                 475                 480 


Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val Met Met Pro Ser Pro 
                485                 490                 495     


Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg Arg Arg Pro Ser Lys 
            500                 505                 510         


Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys Pro Ala Pro Val Ile 
        515                 520                 525             


His Pro Ala Ser Val Ile Phe Thr Val Pro Ala Thr Thr Val Lys Ile 
    530                 535                 540                 


Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln Pro Val Asn Ala Ala 
545                 550                 555                 560 


Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala Thr Leu Leu Val Asn 
                565                 570                 575     


Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro Leu Val Ala Ser Ser 
            580                 585                 590         


Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val Asn Leu Pro Ile Pro 
        595                 600                 605             


Ser Thr Pro Glu Asp Lys Ala His Met Asn Val Asp Ile Ala Cys Ala 
    610                 615                 620                 


Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu Glu Pro Lys Leu Glu 
625                 630                 635                 640 


Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val Phe Pro Lys Val Glu 
                645                 650                 655     


His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln Cys Gln Glu Gly Leu 
            660                 665                 670         


Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val Lys Thr Glu Glu Gly 
        675                 680                 685             


Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile Gln Glu Ser Leu Asn 
    690                 695                 700                 


Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val Lys Met Glu Pro Glu 
705                 710                 715                 720 


Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
                725                 730 


<210> 7115
<211> 520
<212> PRT
<213> Homo sapiens

<400> 7115
Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu 
65                  70                  75                  80  


Val Pro Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu 
                85                  90                  95      


His Ser Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr 
            100                 105                 110         


Arg Leu Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg 
        115                 120                 125             


Arg Glu Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln 
    130                 135                 140                 


Tyr Glu Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala 
145                 150                 155                 160 


Trp Met Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val 
                165                 170                 175     


Gly Leu Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr 
            180                 185                 190         


Val Thr Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His 
        195                 200                 205             


Arg Asn Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile 
    210                 215                 220                 


Ser Phe Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu 
225                 230                 235                 240 


His Asp Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu 
                245                 250                 255     


Trp Ser Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met 
            260                 265                 270         


Gly Leu Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile 
        275                 280                 285             


Ser Leu Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys 
    290                 295                 300                 


Phe Gly Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly 
305                 310                 315                 320 


Phe Lys His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser 
                325                 330                 335     


Leu Met Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile 
            340                 345                 350         


Gln Ala Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His 
        355                 360                 365             


Gly Leu Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile 
    370                 375                 380                 


Ala Ser Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu 
385                 390                 395                 400 


Tyr Cys Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg 
                405                 410                 415     


Pro Ala Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val 
            420                 425                 430         


Cys Ser Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala 
        435                 440                 445             


Ala Pro Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro 
    450                 455                 460                 


Pro Glu Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe 
465                 470                 475                 480 


Glu Lys Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe 
                485                 490                 495     


Asp Leu Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu 
            500                 505                 510         


Asp Ala Leu Ile Ser Leu Leu Ser 
        515                 520 


<210> 7116
<211> 188
<212> PRT
<213> Homo sapiens

<400> 7116
Met Thr Ala Pro Ser Cys Ala Phe Pro Val Gln Phe Arg Gln Pro Ser 
1               5                   10                  15      


Val Ser Gly Leu Ser Gln Ile Thr Lys Ser Leu Tyr Ile Ser Asn Gly 
            20                  25                  30          


Val Ala Ala Asn Asn Lys Leu Met Leu Ser Ser Asn Gln Ile Thr Met 
        35                  40                  45              


Val Ile Asn Val Ser Val Glu Val Val Asn Thr Leu Tyr Glu Asp Ile 
    50                  55                  60                  


Gln Tyr Met Gln Val Pro Val Ala Asp Ser Pro Asn Ser Arg Leu Cys 
65                  70                  75                  80  


Asp Phe Phe Asp Pro Ile Ala Asp His Ile His Ser Val Glu Met Lys 
                85                  90                  95      


Gln Gly Arg Thr Leu Leu His Cys Ala Ala Gly Val Ser Arg Ser Ala 
            100                 105                 110         


Ala Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ala Met Ser Leu Leu 
        115                 120                 125             


Asp Ala His Thr Trp Thr Lys Ser Cys Arg Pro Ile Ile Arg Pro Asn 
    130                 135                 140                 


Ser Gly Phe Trp Glu Gln Leu Ile His Tyr Glu Phe Gln Leu Phe Gly 
145                 150                 155                 160 


Lys Asn Thr Val His Met Val Ser Ser Pro Val Gly Met Ile Pro Asp 
                165                 170                 175     


Ile Tyr Glu Lys Glu Val Arg Leu Met Ile Pro Leu 
            180                 185             


<210> 7117
<211> 393
<212> PRT
<213> Homo sapiens

<400> 7117
Met Asp Ala Ala Thr Leu Thr Tyr Asp Thr Leu Arg Phe Ala Glu Phe 
1               5                   10                  15      


Glu Asp Phe Pro Glu Thr Ser Glu Pro Val Trp Ile Leu Gly Arg Lys 
            20                  25                  30          


Tyr Ser Ile Phe Thr Glu Lys Asp Glu Ile Leu Ser Asp Val Ala Ser 
        35                  40                  45              


Arg Leu Trp Phe Thr Tyr Arg Lys Asn Phe Pro Ala Ile Gly Gly Thr 
    50                  55                  60                  


Gly Pro Thr Ser Asp Thr Gly Trp Gly Cys Met Leu Arg Cys Gly Gln 
65                  70                  75                  80  


Met Ile Phe Ala Gln Ala Leu Val Cys Arg His Leu Gly Arg Asp Trp 
                85                  90                  95      


Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp Ser Tyr Phe Ser Val Leu 
            100                 105                 110         


Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr Tyr Ser Ile His Gln Ile 
        115                 120                 125             


Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Gln Trp Tyr Gly 
    130                 135                 140                 


Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Val Phe Asp Thr 
145                 150                 155                 160 


Trp Ser Ser Leu Ala Val His Ile Ala Met Asp Asn Thr Val Val Met 
                165                 170                 175     


Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser Val Pro Cys Ala Gly Ala 
            180                 185                 190         


Thr Ala Phe Pro Ala Asp Ser Asp Arg His Cys Asn Gly Phe Pro Ala 
        195                 200                 205             


Gly Ala Glu Val Thr Asn Arg Pro Ser Pro Trp Arg Pro Leu Val Leu 
    210                 215                 220                 


Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp Ile Asn Glu Ala Tyr Val 
225                 230                 235                 240 


Glu Thr Leu Lys His Cys Phe Met Met Pro Gln Ser Leu Gly Val Ile 
                245                 250                 255     


Gly Gly Lys Pro Asn Ser Ala His Tyr Phe Ile Gly Tyr Val Gly Glu 
            260                 265                 270         


Glu Leu Ile Tyr Leu Asp Pro His Thr Thr Gln Pro Ala Val Glu Pro 
        275                 280                 285             


Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser Phe His Cys Gln His Pro 
    290                 295                 300                 


Pro Cys Arg Met Ser Ile Ala Glu Leu Asp Pro Ser Ile Ala Val Gly 
305                 310                 315                 320 


Phe Phe Cys Lys Thr Glu Asp Asp Phe Asn Asp Trp Cys Gln Gln Val 
                325                 330                 335     


Lys Lys Leu Ser Leu Leu Gly Gly Ala Leu Pro Met Phe Glu Leu Val 
            340                 345                 350         


Glu Leu Gln Pro Ser His Leu Ala Cys Pro Asp Val Leu Asn Leu Ser 
        355                 360                 365             


Leu Asp Ser Ser Asp Val Glu Arg Leu Glu Arg Phe Phe Asp Ser Glu 
    370                 375                 380                 


Asp Glu Asp Phe Glu Ile Leu Ser Leu 
385                 390             


<210> 7118
<211> 259
<212> PRT
<213> Homo sapiens

<400> 7118
Met Lys Asp Val Asp Asn Leu Lys Ser Ile Lys Glu Glu Trp Val Cys 
1               5                   10                  15      


Glu Thr Gly Ser Asp Asn Gln Pro Leu Gly Asn Asn Gln Gln Ser Asn 
            20                  25                  30          


Cys Glu Tyr Phe Val Asp Ser Leu Phe Glu Glu Ala Gln Lys Val Ser 
        35                  40                  45              


Ser Lys Cys Val Ser Pro Ala Glu Gln Lys Lys Gln Val Asp Val Asn 
    50                  55                  60                  


Ile Lys Leu Trp Lys Asn Gly Phe Thr Val Asn Asp Asp Phe Arg Ser 
65                  70                  75                  80  


Tyr Ser Asp Gly Ala Ser Gln Gln Phe Leu Asn Ser Ile Lys Lys Gly 
                85                  90                  95      


Glu Leu Pro Ser Glu Leu Gln Gly Ile Phe Asp Lys Glu Glu Val Asp 
            100                 105                 110         


Val Lys Val Glu Asp Lys Lys Asn Glu Ile Cys Leu Ser Thr Lys Pro 
        115                 120                 125             


Val Phe Gln Pro Phe Ser Gly Gln Gly His Arg Leu Gly Ser Ala Thr 
    130                 135                 140                 


Pro Lys Ile Val Ser Lys Ala Lys Asn Ile Glu Val Glu Asn Lys Asn 
145                 150                 155                 160 


Asn Leu Ser Ala Val Pro Leu Asn Asn Leu Glu Pro Ile Thr Asn Ile 
                165                 170                 175     


Gln Ile Trp Leu Ala Asn Gly Lys Arg Ile Val Gln Lys Phe Asn Ile 
            180                 185                 190         


Thr His Arg Val Ser His Ile Lys Asp Phe Ile Glu Lys Tyr Gln Gly 
        195                 200                 205             


Ser Gln Arg Ser Pro Pro Phe Ser Leu Ala Thr Ala Leu Pro Val Leu 
    210                 215                 220                 


Arg Leu Leu Asp Glu Thr Leu Thr Leu Glu Glu Ala Asp Leu Gln Asn 
225                 230                 235                 240 


Ala Val Ile Ile Gln Arg Leu Gln Lys Thr Ala Ser Phe Arg Glu Leu 
                245                 250                 255     


Ser Glu His 
            


<210> 7119
<211> 283
<212> PRT
<213> Homo sapiens

<400> 7119
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Glu Pro 
            260                 265                 270         


Pro Ser Trp Pro Ile Ser Ala Thr Ala Arg Gly 
        275                 280             


<210> 7120
<211> 706
<212> PRT
<213> Homo sapiens

<400> 7120
Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys 
1               5                   10                  15      


Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Glu Gln Ser Tyr 
            20                  25                  30          


Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Ala Tyr 
        35                  40                  45              


Ser Gly Thr Pro Leu Thr Glu Glu Lys Glu Lys Ile Val Trp Val Arg 
    50                  55                  60                  


Phe Glu Asn Ala Asp Leu Asn Asp Thr Ser Arg Asn Leu Glu Phe His 
65                  70                  75                  80  


Glu Ile His Ser Thr Gly Asn Glu Pro Pro Leu Leu Ile Met Ile Gly 
                85                  90                  95      


Tyr Ser Asp Gly Met Gln Val Trp Ser Ile Pro Ile Ser Gly Glu Ala 
            100                 105                 110         


Gln Glu Leu Phe Ser Val Arg His Gly Pro Ile Arg Ala Ala Arg Ile 
        115                 120                 125             


Leu Pro Ala Pro Gln Phe Gly Ala Gln Lys Cys Asp Asn Phe Ala Glu 
    130                 135                 140                 


Lys Arg Pro Leu Leu Gly Val Cys Lys Ser Ile Gly Ser Ser Gly Thr 
145                 150                 155                 160 


Ser Pro Pro Tyr Cys Cys Val Asp Leu Tyr Ser Leu Arg Thr Gly Glu 
                165                 170                 175     


Met Val Lys Ser Ile Gln Phe Lys Thr Pro Ile Tyr Asp Leu His Cys 
            180                 185                 190         


Asn Lys Arg Ile Leu Val Val Val Leu Gln Glu Lys Ile Ala Ala Phe 
        195                 200                 205             


Asp Ser Cys Thr Phe Thr Lys Lys Phe Phe Val Thr Ser Cys Tyr Pro 
    210                 215                 220                 


Cys Pro Gly Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu 
225                 230                 235                 240 


Ala Tyr Ala Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly 
                245                 250                 255     


Ala Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala 
            260                 265                 270         


Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr 
        275                 280                 285             


Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala 
    290                 295                 300                 


Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr 
305                 310                 315                 320 


Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu 
                325                 330                 335     


Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys 
            340                 345                 350         


Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr 
        355                 360                 365             


Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His 
    370                 375                 380                 


Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His 
385                 390                 395                 400 


Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp 
                405                 410                 415     


Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe 
            420                 425                 430         


Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser 
        435                 440                 445             


Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu 
    450                 455                 460                 


Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser 
465                 470                 475                 480 


Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly 
                485                 490                 495     


Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro 
            500                 505                 510         


Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro 
        515                 520                 525             


Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg 
    530                 535                 540                 


Thr Gly Pro Tyr Leu Phe Gly Ala Gly Cys Phe Ser Ile Lys Ala Pro 
545                 550                 555                 560 


Trp Ser Tyr Ile Met Thr Lys Tyr Ile Phe Tyr Ile Lys Pro Pro Asn 
                565                 570                 575     


Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met Gly Gly 
            580                 585                 590         


Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp Phe Ala 
        595                 600                 605             


Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln Val Val 
    610                 615                 620                 


Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val Glu His 
625                 630                 635                 640 


Met Met Glu Pro Arg Pro Leu Ser Thr Ala Pro Lys Ile Ser Asp Asp 
                645                 650                 655     


Thr Pro Leu Glu Met Met Thr Ser Pro Arg Ala Ser Trp Thr Leu Val 
            660                 665                 670         


Arg Thr Pro Gln Trp Asn Glu Leu Gln Pro Pro Phe Asn Ala Asn His 
        675                 680                 685             


Pro Leu Leu Leu Ala Ala Asp Ala Val Gln Tyr Tyr Gln Phe Leu Leu 
    690                 695                 700                 


Ala Gly 
705     


<210> 7121
<211> 604
<212> PRT
<213> Homo sapiens

<400> 7121
Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Gly Ala Ala Leu Pro Thr 
1               5                   10                  15      


Val Glu Leu Lys Ile Glu Val Val Leu Pro Glu Lys Glu Arg Gly Lys 
            20                  25                  30          


Glu Glu Leu Ser Ala Ser Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly 
        35                  40                  45              


Asn Gly Thr Ala Arg His Phe His Thr Glu Glu Arg Leu Ser Thr Pro 
    50                  55                  60                  


His Pro Tyr Pro Ser Pro Gln Asp Cys Val Glu Ala Ala Val Cys His 
65                  70                  75                  80  


Val Lys Asp Leu Glu Asn Gly Gln Met Arg Glu Val Glu Leu Gly Trp 
                85                  90                  95      


Gly Lys Val Leu Leu Val Lys Asp Asn Gly Glu Phe His Ala Leu Gly 
            100                 105                 110         


His Lys Cys Pro His Tyr Gly Ala Pro Leu Val Lys Gly Val Leu Ser 
        115                 120                 125             


Arg Gly Arg Val Arg Cys Pro Trp His Gly Ala Cys Phe Asn Ile Ser 
    130                 135                 140                 


Thr Gly Asp Leu Glu Asp Phe Pro Gly Leu Asp Ser Leu His Lys Phe 
145                 150                 155                 160 


Gln Val Lys Ile Glu Lys Glu Lys Val Tyr Val Arg Ala Ser Lys Gln 
                165                 170                 175     


Ala Leu Gln Leu Gln Arg Arg Thr Lys Val Met Ala Lys Cys Ile Ser 
            180                 185                 190         


Pro Ser Ala Gly Tyr Ser Ser Ser Thr Asn Val Leu Ile Val Gly Ala 
        195                 200                 205             


Gly Ala Ala Gly Leu Val Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe 
    210                 215                 220                 


Ser Asp Arg Ile Val Leu Cys Thr Leu Asp Arg His Leu Pro Tyr Asp 
225                 230                 235                 240 


Arg Pro Lys Leu Ser Lys Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala 
                245                 250                 255     


Leu Arg Pro Lys Glu Phe Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr 
            260                 265                 270         


Glu Ala Gln Val Val Thr Val Asp Val Arg Thr Lys Lys Val Val Phe 
        275                 280                 285             


Lys Asp Gly Phe Lys Leu Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly 
    290                 295                 300                 


Ser Ser Pro Lys Thr Leu Ser Cys Lys Gly Lys Glu Val Glu Asn Val 
305                 310                 315                 320 


Phe Thr Ile Arg Thr Pro Glu Asp Ala Asn Arg Val Val Arg Leu Ala 
                325                 330                 335     


Arg Gly Arg Asn Val Val Val Val Gly Ala Gly Phe Leu Gly Met Glu 
            340                 345                 350         


Val Ala Ala Tyr Leu Thr Glu Lys Ala His Ser Val Ser Val Val Glu 
        355                 360                 365             


Leu Glu Glu Thr Pro Phe Arg Arg Phe Leu Gly Glu Arg Val Gly Arg 
    370                 375                 380                 


Ala Leu Met Lys Met Phe Glu Asn Asn Arg Val Lys Phe Tyr Met Gln 
385                 390                 395                 400 


Thr Glu Val Ser Glu Leu Arg Gly Gln Glu Gly Lys Leu Lys Glu Val 
                405                 410                 415     


Val Leu Lys Ser Ser Lys Val Val Arg Ala Asp Val Cys Val Val Gly 
            420                 425                 430         


Ile Gly Ala Val Pro Ala Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly 
        435                 440                 445             


Leu Asp Ser Arg Gly Phe Ile Pro Val Asn Lys Met Met Gln Thr Asn 
    450                 455                 460                 


Val Pro Gly Val Phe Ala Ala Gly Asp Ala Val Thr Phe Pro Leu Ala 
465                 470                 475                 480 


Trp Arg Asn Asn Arg Lys Val Asn Ile Pro His Trp Gln Met Ala His 
                485                 490                 495     


Ala Gln Gly Arg Val Ala Ala Gln Asn Met Leu Ala Gln Glu Ala Glu 
            500                 505                 510         


Met Ser Thr Val Pro Tyr Leu Trp Thr Ala Met Phe Gly Lys Ser Leu 
        515                 520                 525             


Arg Tyr Ala Gly Tyr Gly Glu Gly Phe Asp Asp Val Ile Ile Gln Gly 
    530                 535                 540                 


Asp Leu Glu Glu Leu Lys Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu 
545                 550                 555                 560 


Val Ile Ala Val Ala Ser Met Asn Tyr Asp Pro Ile Val Ser Lys Val 
                565                 570                 575     


Ala Glu Val Leu Ala Ser Gly Arg Ala Ile Arg Lys Arg Glu Val Glu 
            580                 585                 590         


Thr Gly Asp Met Ser Trp Leu Thr Gly Lys Gly Ser 
        595                 600                 


<210> 7122
<211> 247
<212> PRT
<213> Homo sapiens

<400> 7122
Met Ser Thr Ala Ala Val Pro Glu Leu Lys Gln Ile Ser Arg Val Glu 
1               5                   10                  15      


Ala Met Arg Leu Gly Pro Gly Trp Ser His Ser Cys His Ala Met Leu 
            20                  25                  30          


Tyr Ala Ala Asn Pro Gly Gln Leu Phe Gly Arg Ile Pro Met Arg Phe 
        35                  40                  45              


Ser Val Leu Met Gln Met Arg Phe Asp Gly Leu Leu Gly Phe Pro Gly 
    50                  55                  60                  


Gly Phe Val Asp Arg Arg Phe Trp Ser Leu Glu Asp Gly Leu Asn Arg 
65                  70                  75                  80  


Val Leu Gly Leu Gly Leu Gly Cys Leu Arg Leu Thr Glu Ala Asp Tyr 
                85                  90                  95      


Leu Ser Ser His Leu Thr Glu Gly Pro His Arg Val Val Ala His Leu 
            100                 105                 110         


Tyr Ala Arg Gln Leu Thr Leu Glu Gln Leu His Ala Val Glu Ile Ser 
        115                 120                 125             


Ala Val His Ser Arg Asp His Gly Leu Glu Val Gly Pro Pro Pro Gly 
    130                 135                 140                 


Pro Arg Pro Pro Pro Arg Gly Leu Ala Leu Ala Pro Trp Lys Ala Pro 
145                 150                 155                 160 


Met Gly Asn Thr Ser Pro Glu Gly Pro Leu Ala Gly Leu Gly Arg Val 
                165                 170                 175     


Ser Leu Ser Pro Ala Met Gly Trp Gly Glu Gly Ser Gly Ala Gly Arg 
            180                 185                 190         


Pro Gly Lys Glu Gly Arg Gly Trp Gly Pro Ala Leu Gly Leu Pro Gln 
        195                 200                 205             


Gly Cys Val Thr Ser Ala Leu Leu Pro Ala Ile Ala Asn Pro Gly Ser 
    210                 215                 220                 


Gly Gly Val Gly Ser Val Gly Arg Lys Gly Trp Gly Arg Ser Gly Asp 
225                 230                 235                 240 


Cys Leu Gly Ser Trp Glu Thr 
                245         


<210> 7123
<211> 445
<212> PRT
<213> Homo sapiens

<400> 7123
Met Tyr Pro Asn Pro Leu Ile Tyr Cys Thr Cys Trp Asp Pro Trp Asn 
1               5                   10                  15      


Leu Gly Pro Arg Lys Leu Ile Lys Thr Pro Gln Leu Pro Arg Lys Asn 
            20                  25                  30          


Ser Thr Gly Ser Ser Lys Leu Thr Pro Leu Val Pro Ala Pro Lys Asn 
        35                  40                  45              


His Asn Tyr Leu Gln Pro Thr Lys Pro Val Val Ser Pro Lys Met Lys 
    50                  55                  60                  


Ile His Ser Ala Arg Gln Glu Glu Thr Asn Lys Ser Phe Tyr Glu Val 
65                  70                  75                  80  


Ile Asn Val Ser Pro Gly Tyr Gln Leu Val Arg Asn Arg Glu Gln Ile 
                85                  90                  95      


Ser Val Thr Leu Gly Asp Glu Met Phe Asp Arg Lys Lys Arg Trp Glu 
            100                 105                 110         


Ser Glu Ile Pro Asp Lys Gly Arg Phe Ser Arg Thr Asn Ile Ile Ser 
        115                 120                 125             


Asp Leu Glu Glu Gln Ile Ser Glu Leu Thr Ala Ile Ile Glu Gln Met 
    130                 135                 140                 


Asn Arg Asp His Gln Ser Ala Gln Lys Leu Leu Ser Ser Glu Met Asp 
145                 150                 155                 160 


Leu Arg Cys Ala Glu Met Lys Gln Asn Phe Glu Asn Lys Asn Arg Glu 
                165                 170                 175     


Leu Lys Glu Ala His Glu Ala Glu Leu Ser Glu Leu Glu Asn Asn Tyr 
            180                 185                 190         


Lys Ala Ala Leu Lys Ala Glu Lys Leu Ala Ala Gln Glu Lys Leu Glu 
        195                 200                 205             


Glu Met Gly Lys Glu Tyr Lys Tyr Leu Lys Asn Met Phe Arg Thr Tyr 
    210                 215                 220                 


Gln Asp Ser Ile Tyr Asp Glu Met Glu Glu Lys Trp Ser Lys Gln Lys 
225                 230                 235                 240 


Ala Lys Trp Lys Lys Asp Glu Lys Phe Glu Arg Glu Asn Ile Leu Leu 
                245                 250                 255     


Gln Gln Lys Lys Lys Met Thr Lys Lys Phe Glu Met Glu Ser Gly Glu 
            260                 265                 270         


Glu Asp Lys Lys Ile Asn Glu Ser Cys Ser Ala Val Phe Glu Asn Phe 
        275                 280                 285             


Ile Gln Glu Lys Glu Glu Leu Leu Lys Gln His Gln Ser Asp Thr Leu 
    290                 295                 300                 


Gln Leu Glu Glu Leu Arg Lys Thr Lys Glu Val Pro Trp Arg Arg Asp 
305                 310                 315                 320 


Gln Ile Asn Arg His Trp His Asp Val Leu Gln Gln Leu Leu Leu Met 
                325                 330                 335     


Gln Val Met Gln Glu Glu Leu His Ala Gln Ala Leu Ile Leu Glu Ser 
            340                 345                 350         


Leu Asn Thr Asn Leu Tyr Tyr Thr Gln Leu Glu Leu Gln Lys Glu Lys 
        355                 360                 365             


Ala Ile Val Gly Asn Leu Glu Lys Met Leu Gln Thr Lys Phe Ala Glu 
    370                 375                 380                 


Thr Glu Glu Lys Tyr Lys His Thr Ile Gln Ile Leu Thr Glu Glu Asn 
385                 390                 395                 400 


Ile His Leu Lys Gln Lys Ile Ile Ser Lys Asn Glu Glu Ile Cys Glu 
                405                 410                 415     


Gly Cys Ser Gly Arg Leu Ala Ser Ile Thr Val Ser Lys Asp Asp Ser 
            420                 425                 430         


Asp Thr Val Gln Asp Gly Ser Lys Lys Gly Gln Glu Ser 
        435                 440                 445 


<210> 7124
<211> 444
<212> PRT
<213> Homo sapiens

<400> 7124
Phe Arg Val Pro Ala Ala Gly Arg Arg Cys Pro Leu Ala Arg Gly Ala 
1               5                   10                  15      


Arg Arg Pro Pro Asp Ser Ala Cys Gly Arg Phe Pro Pro Asp Pro Gly 
            20                  25                  30          


Ser Pro Pro Glu Glu Glu Asp Ala Asp Leu Ser Glu Arg Glu Glu Ser 
        35                  40                  45              


Trp Leu Leu Ala Glu Arg Glu Glu Asn Gln Glu Ala Glu Phe Pro Gly 
    50                  55                  60                  


Leu Arg Arg Ala Val Gln Leu Asn Leu Ser Arg Pro Ile Glu Glu Gln 
65                  70                  75                  80  


Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile Leu Glu 
                85                  90                  95      


Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg Phe Gln 
            100                 105                 110         


Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro Leu Pro 
        115                 120                 125             


Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu Ile Arg 
    130                 135                 140                 


Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro Pro Phe 
145                 150                 155                 160 


Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu Leu Glu 
                165                 170                 175     


Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val Ala His 
            180                 185                 190         


Gly Thr Asn Ser His Glu Met Ala Ile Val Phe Asn Gln Glu Gly Leu 
        195                 200                 205             


Asn Ala Ile Gln Pro Pro Cys Val Val Gln Asn Phe Ile Asn His Asn 
    210                 215                 220                 


Ala Val Leu Tyr Lys Val Phe Val Val Gly Glu Ser Tyr Thr Val Val 
225                 230                 235                 240 


Gln Arg Pro Ser Leu Lys Asn Phe Ser Ala Gly Thr Ser Asp Arg Glu 
                245                 250                 255     


Ser Ile Phe Phe Asn Ser His Asn Val Ser Lys Pro Glu Ser Ser Ser 
            260                 265                 270         


Val Leu Thr Glu Leu Asp Lys Ile Glu Gly Val Phe Glu Arg Pro Ser 
        275                 280                 285             


Asp Glu Val Ile Arg Glu Leu Ser Arg Ala Leu Arg Gln Ala Leu Gly 
    290                 295                 300                 


Val Ser Leu Phe Gly Ile Asp Ile Ile Ile Asn Asn Gln Thr Gly Gln 
305                 310                 315                 320 


His Ala Val Ile Asp Ile Asn Ala Phe Pro Gly Tyr Glu Gly Val Ser 
                325                 330                 335     


Glu Phe Phe Thr Asp Leu Leu Asn His Ile Ala Thr Val Leu Gln Gly 
            340                 345                 350         


Gln Ser Thr Ala Met Ala Ala Thr Gly Asp Val Ala Leu Leu Arg His 
        355                 360                 365             


Ser Lys Leu Leu Ala Glu Pro Ala Gly Gly Leu Val Gly Glu Arg Thr 
    370                 375                 380                 


Cys Ser Ala Ser Pro Gly Cys Cys Gly Ser Met Met Gly Gln Asp Ala 
385                 390                 395                 400 


Pro Trp Lys Ala Glu Ala Asp Ala Gly Gly Thr Ala Lys Leu Pro His 
                405                 410                 415     


Gln Arg Leu Gly Cys Asn Ala Gly Val Ser Pro Ser Phe Gln Gln His 
            420                 425                 430         


Cys Val Ala Ser Leu Ala Thr Lys Ala Ser Ser Gln 
        435                 440                 


<210> 7125
<211> 287
<212> PRT
<213> Homo sapiens

<400> 7125
Met Cys Gly Arg Arg Arg Arg Gln Arg Ala Ala Leu Leu Ser His Trp 
1               5                   10                  15      


Asp Pro Thr Leu Ser Ser Asp Trp Asp Gly Glu Arg Thr Ala Pro Gln 
            20                  25                  30          


Cys Leu Leu Arg Ile Lys Arg Asp Ile Met Ser Ile Tyr Lys Glu Pro 
        35                  40                  45              


Pro Pro Gly Met Phe Val Val Pro Asp Thr Val Asp Met Thr Lys Ile 
    50                  55                  60                  


His Ala Leu Ile Thr Gly Pro Phe Asp Thr Pro Tyr Glu Gly Gly Phe 
65                  70                  75                  80  


Phe Leu Phe Val Phe Arg Cys Pro Pro Asp Tyr Pro Ile His Pro Pro 
                85                  90                  95      


Arg Val Lys Leu Met Thr Thr Gly Asn Asn Thr Val Arg Phe Asn Pro 
            100                 105                 110         


Asn Phe Tyr Arg Asn Gly Lys Val Cys Leu Ser Ile Leu Gly Thr Trp 
        115                 120                 125             


Thr Gly Pro Ala Trp Ser Pro Ala Gln Ser Ile Ser Ser Val Leu Ile 
    130                 135                 140                 


Ser Ile Gln Ser Leu Met Thr Glu Asn Pro Tyr His Asn Glu Pro Gly 
145                 150                 155                 160 


Phe Glu Gln Glu Arg His Pro Gly Asp Ser Lys Asn Tyr Asn Glu Cys 
                165                 170                 175     


Ile Arg His Glu Thr Ile Arg Val Ala Val Cys Asp Met Met Glu Gly 
            180                 185                 190         


Lys Cys Pro Cys Pro Glu Pro Leu Arg Gly Val Met Glu Lys Ser Phe 
        195                 200                 205             


Leu Glu Tyr Tyr Asp Phe Tyr Glu Val Ala Cys Lys Asp Arg Leu His 
    210                 215                 220                 


Leu Gln Gly Gln Thr Met Gln Asp Pro Phe Gly Glu Lys Arg Gly His 
225                 230                 235                 240 


Phe Asp Tyr Gln Ser Leu Leu Met Arg Leu Gly Leu Ile Arg Gln Lys 
                245                 250                 255     


Val Leu Glu Arg Leu His Asn Glu Asn Ala Glu Met Asp Ser Asp Ser 
            260                 265                 270         


Ser Ser Ser Gly Thr Glu Thr Asp Leu His Gly Ser Leu Arg Val 
        275                 280                 285         


<210> 7126
<211> 283
<212> PRT
<213> Homo sapiens

<400> 7126
Pro Pro Cys Ser Leu Ile Ser Asp Cys Cys Ala Gly Asn Gln Arg Asp 
1               5                   10                  15      


Ser Val Gly Val Gly Pro Ser Glu Pro Gly Cys Tyr Pro Cys Pro Gly 
            20                  25                  30          


Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu Ala Tyr Ala 
        35                  40                  45              


Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly Ala Cys Gly 
    50                  55                  60                  


Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala Ala Lys Thr 
65                  70                  75                  80  


Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr Gln Leu Thr 
                85                  90                  95      


Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala Ile His Ser 
            100                 105                 110         


Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr Val Ile Asp 
        115                 120                 125             


Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu Asp Ser Asp 
    130                 135                 140                 


Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys Pro Val Cys 
145                 150                 155                 160 


Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr Thr Asp Thr 
                165                 170                 175     


Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His Pro Trp Ser 
            180                 185                 190         


Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His Arg Gly Glu 
        195                 200                 205             


Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp Cys Arg Trp 
    210                 215                 220                 


Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe Pro Ile Asn 
225                 230                 235                 240 


Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser Pro Arg Val 
                245                 250                 255     


Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu Glu Glu Ile 
            260                 265                 270         


Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg 
        275                 280             


<210> 7127
<211> 744
<212> PRT
<213> Homo sapiens

<400> 7127
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser 
                165                 170                 175     


Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser 
            180                 185                 190         


Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe 
        195                 200                 205             


Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys 
    210                 215                 220                 


Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg 
225                 230                 235                 240 


Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val 
                245                 250                 255     


Asp Val Gln Lys Ile Val Gly Ser Gln Ile His Phe His Gly Lys Lys 
            260                 265                 270         


Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His 
        275                 280                 285             


Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe 
    290                 295                 300                 


Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln 
305                 310                 315                 320 


Ile Thr Pro Asn Pro Val Thr Gln His Val Gln Ser Ala Ala Asn Pro 
                325                 330                 335     


Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser 
            340                 345                 350         


Ser Ala Ala Ala Ser Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val 
        355                 360                 365             


Pro Asn Thr Val Phe Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr 
    370                 375                 380                 


Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys 
385                 390                 395                 400 


Ile Ile Thr Asn Arg Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser 
                405                 410                 415     


Phe Val Asn Asp Val Asp Val Gln Lys Ile Val Gly Ser Gln Ile His 
            420                 425                 430         


Phe His Gly Lys Lys Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys 
        435                 440                 445             


Leu Cys Ala Arg His Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro 
    450                 455                 460                 


Pro Pro Pro Gln Phe Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr 
465                 470                 475                 480 


Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro Val Thr Gln His Val Gln 
                485                 490                 495     


Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly Gln Val Ile Thr Gly Cys 
            500                 505                 510         


Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr Pro Thr Tyr Pro Asp Ser 
        515                 520                 525             


Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
    530                 535                 540                 


Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe Gln Val Thr Ala Gly Tyr 
545                 550                 555                 560 


Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser 
                565                 570                 575     


Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln 
            580                 585                 590         


Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr Ala Gly Tyr 
        595                 600                 605             


Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser 
    610                 615                 620                 


Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln 
625                 630                 635                 640 


Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr 
                645                 650                 655     


Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser 
            660                 665                 670         


Pro Phe Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
        675                 680                 685             


Ala Phe Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr 
    690                 695                 700                 


Gln Phe His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly 
705                 710                 715                 720 


Glu Gln Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu 
                725                 730                 735     


Val Cys Leu Ile Gln Arg Arg Asp 
            740                 


<210> 7128
<211> 362
<212> PRT
<213> Homo sapiens

<400> 7128
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Phe Thr Glu Ile Ser His Arg Ile Leu Cys Ser Tyr 
225                 230                 235                 240 


Asn Thr Asn Ile Glu Glu Leu Phe Ala Glu Ile Asp Gln Cys Leu Ala 
                245                 250                 255     


Ile Asn Arg Ser Val Leu Gln Gln Leu Glu Glu Lys Cys Gly His Glu 
            260                 265                 270         


Ile Thr Glu Glu Glu Trp Glu Lys Ile Gln Val Gln Ala Leu Arg Arg 
        275                 280                 285             


Glu Thr His Glu Cys Ser Ile Cys Leu Ala Pro Leu Ser Ala Ala Gly 
    290                 295                 300                 


Gly Gln Arg Val Gly Ala Gly Arg Arg Ser Arg Glu Met Ala Leu Leu 
305                 310                 315                 320 


Ser Cys Ser His Val Phe His His Ala Cys Leu Leu Ala Leu Glu Glu 
                325                 330                 335     


Phe Ser Val Gly Asp Arg Pro Pro Phe His Ala Cys Pro Leu Cys Arg 
            340                 345                 350         


Ser Cys Tyr Gln Lys Lys Ile Leu Glu Cys 
        355                 360         


<210> 7129
<211> 709
<212> PRT
<213> Homo sapiens

<400> 7129
Met Ala Asp Ala Gly Ile Arg Arg Val Val Pro Ser Asp Leu Tyr Pro 
1               5                   10                  15      


Leu Val Leu Gly Phe Leu Arg Asp Asn Gln Leu Ser Glu Val Ala Asn 
            20                  25                  30          


Lys Phe Ala Lys Ala Thr Gly Ala Thr Gln Gln Asp Ala Asn Ala Ser 
        35                  40                  45              


Ser Leu Leu Asp Ile Tyr Ser Phe Trp Leu Lys Ser Ala Lys Val Pro 
    50                  55                  60                  


Glu Arg Lys Leu Gln Ala Asn Gly Pro Val Ala Lys Lys Ala Lys Lys 
65                  70                  75                  80  


Lys Ala Ser Ser Ser Asp Ser Glu Asp Ser Ser Glu Glu Glu Glu Glu 
                85                  90                  95      


Val Gln Gly Pro Pro Ala Lys Lys Ala Ala Val Pro Ala Lys Arg Val 
            100                 105                 110         


Gly Leu Pro Pro Gly Lys Ala Ala Ala Lys Ala Ser Glu Ser Ser Ser 
        115                 120                 125             


Ser Glu Glu Ser Ser Asp Asp Asp Asp Glu Glu Asp Gln Lys Lys Gln 
    130                 135                 140                 


Pro Val Gln Lys Gly Val Lys Pro Gln Ala Lys Ala Ala Lys Ala Pro 
145                 150                 155                 160 


Pro Lys Lys Ala Lys Ser Ser Asp Ser Asp Ser Asp Ser Ser Ser Glu 
                165                 170                 175     


Asp Glu Pro Pro Lys Asn Gln Lys Pro Lys Ile Thr Pro Val Thr Val 
            180                 185                 190         


Lys Ala Gln Thr Lys Ala Pro Pro Lys Pro Ala Arg Ala Ala Pro Lys 
        195                 200                 205             


Ile Ala Asn Gly Lys Ala Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    210                 215                 220                 


Ser Ser Ser Asp Asp Ser Glu Glu Glu Lys Ala Ala Ala Thr Pro Lys 
225                 230                 235                 240 


Lys Val Trp Thr Ile Thr Ser Val Arg Ala Glu Thr Val Pro Lys Lys 
                245                 250                 255     


Gln Val Val Ala Lys Ala Pro Val Lys Ala Ala Thr Thr Pro Thr Arg 
            260                 265                 270         


Lys Ser Ser Ser Ser Glu Asp Ser Ser Ser Asp Glu Glu Glu Glu Gln 
        275                 280                 285             


Lys Lys Pro Met Lys Asn Lys Pro Gly Pro Tyr Ser Ser Val Pro Pro 
    290                 295                 300                 


Pro Ser Ala Pro Pro Pro Lys Lys Ser Leu Gly Thr Gln Pro Pro Lys 
305                 310                 315                 320 


Lys Ala Val Glu Lys Gln Gln Pro Val Glu Ser Ser Glu Asp Ser Ser 
                325                 330                 335     


Asp Glu Ser Asp Ser Ser Ser Glu Glu Glu Lys Lys Pro Pro Thr Lys 
            340                 345                 350         


Ala Val Val Ser Lys Ala Thr Thr Lys Pro Pro Pro Ala Lys Lys Ala 
        355                 360                 365             


Ala Glu Ser Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Glu Asp Asp 
    370                 375                 380                 


Glu Ala Pro Ser Lys Pro Ala Gly Thr Thr Lys Asn Ser Ser Asn Lys 
385                 390                 395                 400 


Pro Ala Val Thr Thr Lys Ser Pro Ala Val Lys Pro Ala Ala Ala Pro 
                405                 410                 415     


Lys Gln Pro Val Gly Gly Gly Gln Lys Leu Leu Thr Arg Lys Ala Asp 
            420                 425                 430         


Ser Ser Ser Ser Glu Glu Glu Ser Ser Ser Ser Glu Glu Glu Lys Thr 
        435                 440                 445             


Lys Lys Met Val Ala Thr Thr Lys Pro Lys Ala Thr Ala Lys Ala Ala 
    450                 455                 460                 


Leu Ser Leu Pro Ala Lys Gln Ala Pro Gln Gly Ser Arg Asp Ser Ser 
465                 470                 475                 480 


Ser Asp Ser Asp Ser Ser Ser Ser Glu Glu Glu Glu Glu Lys Thr Ser 
                485                 490                 495     


Lys Ser Ala Val Lys Lys Lys Pro Gln Lys Val Ala Gly Gly Ala Ala 
            500                 505                 510         


Pro Ser Lys Pro Ala Ser Ala Lys Lys Gly Lys Ala Glu Ser Ser Asn 
        515                 520                 525             


Ser Ser Ser Ser Asp Asp Ser Ser Glu Glu Glu Glu Glu Lys Leu Lys 
    530                 535                 540                 


Gly Lys Gly Ser Pro Arg Pro Gln Ala Pro Lys Ala Asn Gly Thr Ser 
545                 550                 555                 560 


Ala Leu Thr Ala Gln Asn Gly Lys Ala Ala Lys Asn Ser Glu Glu Glu 
                565                 570                 575     


Glu Glu Glu Lys Lys Lys Ala Ala Val Val Val Ser Lys Ser Gly Ser 
            580                 585                 590         


Leu Lys Lys Arg Lys Gln Asn Glu Ala Ala Lys Glu Ala Glu Thr Pro 
        595                 600                 605             


Gln Ala Lys Lys Ile Lys Leu Gln Thr Pro Asn Thr Phe Pro Lys Arg 
    610                 615                 620                 


Lys Lys Gly Glu Lys Arg Ala Ser Ser Pro Phe Arg Arg Val Arg Glu 
625                 630                 635                 640 


Glu Glu Ile Glu Val Asp Ser Arg Val Ala Asp Asn Ser Phe Asp Ala 
                645                 650                 655     


Lys Arg Gly Ala Ala Gly Asp Trp Gly Glu Arg Ala Asn Gln Val Leu 
            660                 665                 670         


Lys Phe Thr Lys Gly Lys Ser Phe Arg His Glu Lys Thr Lys Lys Lys 
        675                 680                 685             


Arg Gly Ser Tyr Arg Gly Gly Ser Ile Ser Val Gln Val Asn Ser Ile 
    690                 695                 700                 


Lys Phe Asp Ser Glu 
705                 


<210> 7130
<211> 185
<212> PRT
<213> Homo sapiens

<400> 7130
Met Gln Gln Lys Ser Gln Lys Lys Ala Glu Leu Leu Asp Asn Glu Lys 
1               5                   10                  15      


Pro Ala Ala Val Val Ala Pro Ile Thr Thr Gly Tyr Thr Val Lys Ile 
            20                  25                  30          


Ser Asn Tyr Gly Trp Asp Gln Ser Asp Lys Phe Val Lys Ile Tyr Ile 
        35                  40                  45              


Thr Leu Thr Gly Val His Gln Val Pro Thr Glu Asn Val Gln Val His 
    50                  55                  60                  


Phe Thr Glu Arg Ser Phe Asp Leu Leu Val Lys Asn Leu Asn Gly Lys 
65                  70                  75                  80  


Ser Tyr Ser Met Ile Val Asn Asn Leu Leu Lys Pro Ile Ser Val Glu 
                85                  90                  95      


Gly Ser Ser Lys Lys Val Lys Thr Asp Thr Val Leu Ile Leu Cys Arg 
            100                 105                 110         


Lys Lys Val Glu Asn Thr Arg Trp Asp Tyr Leu Thr Gln Val Glu Lys 
        115                 120                 125             


Glu Cys Lys Glu Lys Glu Lys Pro Ser Tyr Asp Thr Glu Thr Asp Pro 
    130                 135                 140                 


Ser Glu Gly Leu Met Asn Val Leu Lys Lys Ile Tyr Glu Asp Gly Asp 
145                 150                 155                 160 


Asp Asp Met Lys Arg Thr Ile Asn Lys Ala Trp Val Glu Ser Arg Glu 
                165                 170                 175     


Lys Gln Ala Lys Gly Asp Thr Glu Phe 
            180                 185 


<210> 7131
<211> 587
<212> PRT
<213> Homo sapiens

<400> 7131
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe 
        35                  40                  45              


Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu 
    50                  55                  60                  


Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys 
65                  70                  75                  80  


Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile 
                85                  90                  95      


Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile Thr Ala Gly Ala 
            100                 105                 110         


Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe Gly Pro Asp Gly 
        115                 120                 125             


Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser Ala Cys Phe Thr Leu 
    130                 135                 140                 


Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile Gly Gly Gly Lys 
145                 150                 155                 160 


Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys Ser Ser Ala Gln 
                165                 170                 175     


Gly Lys Pro Leu Ala Leu Lys Val Phe Val Ala Gly Arg Asn Arg Leu 
            180                 185                 190         


Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe Arg Val Ile Gly 
        195                 200                 205             


Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile Asn His Pro Gly 
    210                 215                 220                 


Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro Leu Leu Arg Val 
225                 230                 235                 240 


Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly Ala Val Ala Met 
                245                 250                 255     


Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val Ile Asn Phe Gly 
            260                 265                 270         


Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile Ala Asp Ala Ile 
        275                 280                 285             


Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu Ser Phe Cys Glu 
    290                 295                 300                 


Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala Met Ala Asp Lys 
305                 310                 315                 320 


Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr Leu Gly Glu Glu 
                325                 330                 335     


Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe Asn Met Ala Lys 
            340                 345                 350         


Val Leu Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Asp Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Gln Gln 
385                 390                 395                 400 


Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg Lys Ile Leu Asp 
                405                 410                 415     


Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser Pro Pro Pro Ala 
            420                 425                 430         


Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu Lys Leu Leu Arg 
        435                 440                 445             


Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln Thr Asp Thr Ser 
    450                 455                 460                 


Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val Ser Ser Val Phe 
465                 470                 475                 480 


Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp Ala Val Asp Ala 
                485                 490                 495     


Leu Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn Ser Asn Thr Phe 
            500                 505                 510         


Leu Thr Arg Leu Leu Val His Met Gly Leu Leu Lys Ser Glu Asp Lys 
        515                 520                 525             


Val Lys Ala Ile Ala Asn Leu Tyr Gly Pro Leu Met Ala Leu Asn His 
    530                 535                 540                 


Met Val Gln Gln Asp Tyr Phe Pro Lys Ala Leu Ala Pro Leu Leu Leu 
545                 550                 555                 560 


Ala Phe Val Thr Lys Pro Asn Ser Ala Leu Glu Ser Cys Ser Phe Ala 
                565                 570                 575     


Arg His Ser Leu Leu Gln Thr Leu Tyr Lys Val 
            580                 585         


<210> 7132
<211> 365
<212> PRT
<213> Homo sapiens

<400> 7132
Met Lys Glu Leu Trp Cys Val Met Asp Trp Ala Val Pro Gly Leu Leu 
1               5                   10                  15      


Gly Ser Gly Thr Tyr Phe Lys Lys Gln Phe Ser Asp Pro Val Glu His 
            20                  25                  30          


Gly Gln Arg His Thr Ala Thr Lys Arg Glu Leu Ala Thr Gly Arg Lys 
        35                  40                  45              


Ala Met Gln Arg Leu Ala Lys Lys Met Ser Gly Trp Phe Leu Arg Arg 
    50                  55                  60                  


Thr Lys Thr Leu Ile Lys Asp Gln Leu Pro Lys Lys Glu Asp Arg Met 
65                  70                  75                  80  


Val Tyr Cys Ser Leu Thr Asp Phe Gln Lys Ala Val Tyr Gln Thr Val 
                85                  90                  95      


Leu Glu Thr Glu Asp Val Thr Leu Ile Leu Gln Ser Ser Glu Pro Cys 
            100                 105                 110         


Thr Cys Arg Ser Gly Gln Lys Arg Arg Asn Cys Cys Tyr Lys Thr Asn 
        115                 120                 125             


Ser His Gly Glu Thr Val Lys Thr Leu Tyr Leu Ser Tyr Leu Thr Val 
    130                 135                 140                 


Leu Gln Lys Val Ala Asn His Val Ala Leu Leu Gln Ala Ala Ser Thr 
145                 150                 155                 160 


Ser Lys Gln Gln Glu Thr Leu Ile Lys Arg Ile Cys Asp Gln Val Phe 
                165                 170                 175     


Ser Arg Phe Pro Asp Phe Val Gln Lys Ser Lys Asp Ala Ala Phe Glu 
            180                 185                 190         


Thr Leu Ser Asp Pro Lys Tyr Ser Gly Lys Met Lys Val Leu Gln Gln 
        195                 200                 205             


Leu Leu Asn His Cys Arg Lys Asn Arg Asp Lys Val Leu Leu Phe Ser 
    210                 215                 220                 


Phe Ser Thr Lys Leu Leu Asp Val Leu Gln Gln Tyr Cys Met Ala Ser 
225                 230                 235                 240 


Gly Leu Asp Tyr Arg Arg Leu Asp Gly Ser Thr Lys Ser Glu Glu Arg 
                245                 250                 255     


Leu Lys Ile Val Lys Glu Phe Asn Ser Thr Gln Asp Val Asn Ile Cys 
            260                 265                 270         


Leu Val Ser Thr Met Ala Gly Gly Leu Gly Leu Asn Phe Val Gly Ala 
        275                 280                 285             


Asn Val Val Val Leu Phe Asp Pro Thr Trp Asn Pro Ala Asn Asp Leu 
    290                 295                 300                 


Gln Ala Ile Asp Arg Thr Gln Thr His Cys Arg Arg Glu Arg Asp Ala 
305                 310                 315                 320 


Glu Pro Leu Ser Ser Ala Pro Gly Leu Gln Asn Gly Ser Glu Asn Ala 
                325                 330                 335     


Val Pro Tyr Pro Trp Trp Cys Cys Val Thr Gly Ala Ser Ile Ser Cys 
            340                 345                 350         


Trp Arg Cys Glu Ile Cys Arg Ile Gln Asp Val Leu Glu 
        355                 360                 365 


<210> 7133
<211> 367
<212> PRT
<213> Homo sapiens

<400> 7133
Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
1               5                   10                  15      


Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
            20                  25                  30          


Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
        35                  40                  45              


Asp Tyr Ala Gly Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser 
    50                  55                  60                  


Thr Gln Ala His Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn 
65                  70                  75                  80  


Gly Ser Leu Thr Gln Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln 
                85                  90                  95      


Ser Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys 
            100                 105                 110         


Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu 
        115                 120                 125             


Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile 
    130                 135                 140                 


Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn 
145                 150                 155                 160 


Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val 
                165                 170                 175     


Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr 
            180                 185                 190         


Asn Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro 
        195                 200                 205             


Val Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe 
    210                 215                 220                 


Gln Ala Asp Val Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly 
225                 230                 235                 240 


Arg Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro 
                245                 250                 255     


Tyr Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu 
            260                 265                 270         


Arg Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro 
        275                 280                 285             


Thr Ala Ile Pro Ala Tyr Pro Gly Val Asp Met Gln Pro Thr Asp Met 
    290                 295                 300                 


His Ser Leu Leu Leu Gln Pro Gln Pro Pro Leu Leu Gln Pro Leu Gln 
305                 310                 315                 320 


Pro Leu Thr Val Thr Val Met Ala Gly Cys Thr Gln Pro Thr Pro Thr 
                325                 330                 335     


Met Pro Leu Pro Leu Pro Leu Ala Met Glu Leu Ala Leu Trp Arg Val 
            340                 345                 350         


Tyr Thr Glu Val Ala Thr Ala Asp Leu Pro Pro Thr Glu Val Thr 
        355                 360                 365         


<210> 7134
<211> 587
<212> PRT
<213> Homo sapiens

<400> 7134
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe 
        35                  40                  45              


Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu 
    50                  55                  60                  


Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys 
65                  70                  75                  80  


Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile 
                85                  90                  95      


Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile Thr Ala Gly Ala 
            100                 105                 110         


Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe Gly Pro Asp Gly 
        115                 120                 125             


Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser Ala Cys Phe Thr Leu 
    130                 135                 140                 


Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile Gly Gly Gly Lys 
145                 150                 155                 160 


Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys Ser Ser Ala Gln 
                165                 170                 175     


Gly Lys Pro Leu Ala Leu Lys Val Phe Val Ala Gly Arg Asn Arg Leu 
            180                 185                 190         


Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe Arg Val Ile Gly 
        195                 200                 205             


Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile Asn His Pro Gly 
    210                 215                 220                 


Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro Leu Leu Arg Val 
225                 230                 235                 240 


Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly Ala Val Ala Met 
                245                 250                 255     


Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val Ile Asn Phe Gly 
            260                 265                 270         


Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile Ala Asp Ala Ile 
        275                 280                 285             


Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu Ser Phe Cys Glu 
    290                 295                 300                 


Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala Met Ala Asp Lys 
305                 310                 315                 320 


Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr Leu Gly Glu Glu 
                325                 330                 335     


Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe Asn Met Ala Lys 
            340                 345                 350         


Val Leu Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Asp Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Gln Gln 
385                 390                 395                 400 


Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg Lys Ile Leu Asp 
                405                 410                 415     


Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser Pro Pro Pro Ala 
            420                 425                 430         


Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu Lys Leu Leu Arg 
        435                 440                 445             


Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln Thr Asp Thr Ser 
    450                 455                 460                 


Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val Ser Ser Val Phe 
465                 470                 475                 480 


Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp Ala Val Asp Ala 
                485                 490                 495     


Leu Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn Ser Asn Thr Phe 
            500                 505                 510         


Leu Thr Arg Leu Leu Val His Met Gly Leu Leu Lys Ser Glu Asp Lys 
        515                 520                 525             


Val Lys Ala Ile Ala Asn Leu Tyr Gly Pro Leu Met Ala Leu Asn His 
    530                 535                 540                 


Met Val Gln Gln Asp Tyr Phe Pro Lys Ala Leu Ala Pro Leu Leu Leu 
545                 550                 555                 560 


Ala Phe Val Thr Lys Pro Asn Ser Ala Leu Glu Ser Cys Ser Phe Ala 
                565                 570                 575     


Arg His Ser Leu Leu Gln Thr Leu Tyr Lys Val 
            580                 585         


<210> 7135
<211> 380
<212> PRT
<213> Homo sapiens

<400> 7135
Met Asp Ala Ala Thr Leu Thr Tyr Asp Thr Leu Arg Phe Ala Glu Phe 
1               5                   10                  15      


Glu Asp Phe Pro Glu Thr Ser Glu Pro Val Trp Ile Leu Gly Arg Lys 
            20                  25                  30          


Tyr Ser Ile Phe Thr Glu Lys Asp Glu Ile Leu Ser Asp Val Ala Ser 
        35                  40                  45              


Arg Leu Trp Phe Thr Tyr Arg Lys Asn Phe Pro Ala Ile Gly Gly Thr 
    50                  55                  60                  


Gly Pro Thr Ser Asp Thr Gly Trp Gly Cys Met Leu Arg Cys Gly Gln 
65                  70                  75                  80  


Met Ile Phe Ala Gln Ala Leu Val Cys Arg His Leu Gly Arg Asp Trp 
                85                  90                  95      


Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp Ser Tyr Phe Ser Val Leu 
            100                 105                 110         


Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr Tyr Ser Ile His Gln Ile 
        115                 120                 125             


Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Gln Trp Tyr Gly 
    130                 135                 140                 


Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Val Phe Asp Thr 
145                 150                 155                 160 


Trp Ser Ser Leu Ala Val His Ile Ala Met Asp Asn Thr Val Val Met 
                165                 170                 175     


Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser Val Pro Cys Ala Gly Ala 
            180                 185                 190         


Thr Ala Phe Pro Ala Asp Ser Asp Arg His Cys Asn Gly Phe Pro Ala 
        195                 200                 205             


Gly Ala Glu Val Thr Asn Arg Pro Ser Pro Trp Arg Pro Leu Val Leu 
    210                 215                 220                 


Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp Ile Asn Glu Ala Tyr Val 
225                 230                 235                 240 


Glu Thr Leu Lys His Cys Phe Met Met Pro Gln Ser Leu Gly Val Ile 
                245                 250                 255     


Gly Gly Lys Pro Asn Ser Ala His Tyr Phe Ile Gly Tyr Val Gly Glu 
            260                 265                 270         


Glu Leu Ile Tyr Leu Asp Pro His Thr Thr Gln Pro Ala Val Glu Pro 
        275                 280                 285             


Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser Phe His Cys Gln His Pro 
    290                 295                 300                 


Pro Cys Arg Met Ser Ile Ala Glu Leu Asp Pro Ser Ile Ala Val Gly 
305                 310                 315                 320 


Phe Phe Cys Lys Thr Glu Asp Asp Phe Asn Asp Trp Cys Gln Gln Val 
                325                 330                 335     


Lys Lys Leu Ser Leu Leu Gly Gly Ala Leu Pro Met Phe Glu Leu Val 
            340                 345                 350         


Glu Leu Gln Pro Ser His Leu Ala Cys Pro Asp Val Leu Asn Leu Ser 
        355                 360                 365             


Leu Gly Glu Ser Cys Gln Val Gln Ile Leu Leu Met 
    370                 375                 380 


<210> 7136
<211> 707
<212> PRT
<213> Homo sapiens

<400> 7136
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Thr Ile 
            260                 265                 270         


Arg Lys Ala Gln Asn Leu Leu Lys Gln Tyr Ser Gln His Gly Leu Asp 
        275                 280                 285             


Gly Lys Lys Gly Gly Ser Asn Leu Ile Pro Leu Glu Gly His Glu His 
    290                 295                 300                 


Asp Phe Arg Val Lys His Leu Ser Glu Ala Leu Asn Asp Lys His Gly 
305                 310                 315                 320 


Pro Leu Ala Gly Arg Asp Asp Met Leu Asp Val Glu Thr Asp Ala Tyr 
                325                 330                 335     


Ile His Cys Val Ser Ala Phe Val Lys Leu Ala Gln Ser Glu Tyr Gln 
            340                 345                 350         


Leu Leu Ala Asp Ile Ile Pro Glu His His Gln Lys Lys Thr Phe Asp 
        355                 360                 365             


Ser Leu Ile Gln Asp Ala Leu Asp Gly Leu Met Leu Glu Gly Glu Asn 
    370                 375                 380                 


Ile Val Ser Ala Ala Arg Lys Ala Ile Val Arg His Asp Phe Ser Thr 
385                 390                 395                 400 


Val Leu Thr Val Phe Pro Ile Leu Arg His Leu Lys Gln Thr Lys Pro 
                405                 410                 415     


Glu Phe Asp Gln Val Leu Gln Gly Thr Ala Ala Ser Thr Lys Asn Lys 
            420                 425                 430         


Leu Pro Gly Leu Ile Thr Ser Met Glu Thr Ile Gly Ala Lys Ala Leu 
        435                 440                 445             


Glu Asp Phe Ala Asp Asn Ile Lys Asn Asp Pro Asp Lys Glu Tyr Asn 
    450                 455                 460                 


Met Pro Lys Asp Gly Thr Val His Glu Leu Thr Ser Asn Ala Ile Leu 
465                 470                 475                 480 


Phe Leu Gln Gln Leu Leu Asp Phe Gln Glu Thr Ala Gly Ala Met Leu 
                485                 490                 495     


Ala Ser Gln Glu Thr Ser Ser Ser Ala Thr Ser Tyr Ser Ser Glu Phe 
            500                 505                 510         


Ser Lys Arg Leu Leu Ser Thr Tyr Ile Cys Lys Val Leu Gly Asn Leu 
        515                 520                 525             


Gln Leu Asn Leu Leu Ser Lys Ser Lys Val Tyr Glu Asp Pro Ala Leu 
    530                 535                 540                 


Ser Ala Ile Phe Leu His Asn Asn Tyr Asn Tyr Ile Leu Lys Ser Leu 
545                 550                 555                 560 


Glu Lys Ser Glu Leu Ile Gln Leu Val Ala Val Thr Gln Lys Thr Ala 
                565                 570                 575     


Glu Arg Ser Tyr Arg Glu His Ile Glu Gln Gln Ile Gln Thr Tyr Gln 
            580                 585                 590         


Arg Ser Trp Leu Lys Val Thr Asp Tyr Ile Ala Glu Lys Asn Leu Pro 
        595                 600                 605             


Val Phe Gln Pro Gly Val Lys Leu Arg Asp Lys Glu Arg Gln Ile Ile 
    610                 615                 620                 


Lys Glu Arg Phe Lys Gly Phe Asn Asp Gly Leu Glu Glu Leu Cys Lys 
625                 630                 635                 640 


Ile Gln Lys Ala Trp Ala Ile Pro Asp Thr Glu Gln Arg Asp Arg Ile 
                645                 650                 655     


Arg Gln Ala Gln Lys Thr Ile Val Lys Glu Thr Tyr Gly Ala Phe Leu 
            660                 665                 670         


Gln Lys Phe Gly Ser Val Pro Phe Thr Lys Asn Pro Glu Lys Tyr Ile 
        675                 680                 685             


Lys Tyr Gly Val Glu Gln Val Gly Asp Met Ile Asp Arg Leu Phe Asp 
    690                 695                 700                 


Thr Ser Ala 
705         


<210> 7137
<211> 341
<212> PRT
<213> Homo sapiens

<400> 7137
Met Ala Gln Glu Ser Pro Lys Asn Ser Ala Ala Glu Ile Pro Val Thr 
1               5                   10                  15      


Ser Asn Gly Glu Val Asp Asp Ser Arg Glu His Ser Phe Asn Arg Asp 
            20                  25                  30          


Leu Lys His Ser Leu Pro Ser Gly Leu Gly Leu Ser Glu Thr Gln Ile 
        35                  40                  45              


Thr Ser His Gly Phe Asp Asn Thr Lys Glu Gly Val Ile Glu Ala Gly 
    50                  55                  60                  


Ala Phe Gln Gly Gly Gln Arg Thr Gln Thr Lys Ser Gly Pro Val Ile 
65                  70                  75                  80  


Leu Ala Asp Glu Ile Lys Asn Pro Ala Met Glu Lys Leu Glu Leu Val 
                85                  90                  95      


Arg Lys Trp Ser Leu Asn Thr Tyr Lys Cys Thr Arg Gln Ile Ile Ser 
            100                 105                 110         


Glu Lys Leu Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Ala 
        115                 120                 125             


Gln Ile Asp Ile Leu Arg Asp Asn Lys Lys Lys Tyr Glu Asn Ile Leu 
    130                 135                 140                 


Lys Leu Ala Gln Thr Leu Ser Thr Gln Leu Phe Gln Met Val His Thr 
145                 150                 155                 160 


Gln Arg Gln Leu Gly Asp Ala Phe Ala Asp Leu Ser Leu Lys Ser Leu 
                165                 170                 175     


Glu Leu His Glu Glu Phe Gly Tyr Asn Ala Asp Thr Gln Lys Leu Leu 
            180                 185                 190         


Ala Lys Asn Gly Glu Thr Leu Leu Gly Ala Ile Asn Phe Phe Ile Ala 
        195                 200                 205             


Ser Val Asn Thr Leu Val Asn Lys Thr Ile Glu Asp Thr Leu Met Thr 
    210                 215                 220                 


Val Lys Gln Tyr Glu Ser Ala Arg Ile Glu Tyr Asp Ala Tyr Arg Thr 
225                 230                 235                 240 


Asp Leu Glu Glu Leu Asn Leu Gly Pro Arg Asp Ala Asn Thr Leu Pro 
                245                 250                 255     


Lys Ile Glu Gln Ser Gln His Leu Phe Gln Ala His Lys Glu Lys Tyr 
            260                 265                 270         


Asp Lys Met Arg Asn Asp Val Ser Val Lys Leu Lys Phe Leu Glu Glu 
        275                 280                 285             


Asn Lys Val Lys Val Leu His Asn Gln Leu Val Leu Phe His Asn Ala 
    290                 295                 300                 


Ile Ala Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
305                 310                 315                 320 


Lys Gln Phe His Ile Lys Leu Lys Thr Pro Gly Val Asp Ala Pro Ser 
                325                 330                 335     


Trp Leu Glu Glu Gln 
            340     


<210> 7138
<211> 495
<212> PRT
<213> Homo sapiens

<400> 7138
Met Ala Gly Val Gly Arg Ser Gly Gly Pro Trp Gly Arg Thr Arg Gly 
1               5                   10                  15      


Gly Arg Ser Gly Arg Leu Gly Val Ser Leu Gly Ala Leu Ser Ser Leu 
            20                  25                  30          


Pro Leu Glu Glu Leu Pro Arg Pro Leu Cys Cys Arg Arg Cys Arg Arg 
        35                  40                  45              


His Phe Gly Phe Ala Leu Arg Gly Glu Thr Ile Pro Val Ser Val Ala 
    50                  55                  60                  


Gly Ser Ala Ser Ser Gln Phe Ala Pro Leu Ala Leu His Leu Ser Leu 
65                  70                  75                  80  


Leu Leu Ser Arg Ile Ser Ala Ser Arg Leu Thr Arg Trp Pro Pro Pro 
                85                  90                  95      


Asp Lys Arg Glu Gly Ser Ala Val Asp Pro Gly Lys Arg Arg Ser Leu 
            100                 105                 110         


Ala Ala Thr Pro Ser Ser Ser Leu Pro Cys Thr Leu Ile Ala Leu Gly 
        115                 120                 125             


Leu Arg His Glu Lys Glu Ala Asn Glu Leu Met Glu Asp Leu Phe Glu 
    130                 135                 140                 


Thr Phe Gln Asp Glu Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro 
145                 150                 155                 160 


Glu Glu Glu Glu Arg Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro 
                165                 170                 175     


Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln 
            180                 185                 190         


His Gln Ile Ala Lys Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro 
        195                 200                 205             


Ser Ala Lys Gln Gln Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys 
    210                 215                 220                 


Glu Val His Gln Thr Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu 
225                 230                 235                 240 


Gln Gln Gln Met Gln Gln His Val Gln Leu Leu Thr Gln Ile His Leu 
                245                 250                 255     


Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg 
            260                 265                 270         


Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu 
        275                 280                 285             


His His Gln Tyr Asn Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn 
    290                 295                 300                 


Leu Met Gly Ala Met Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser 
305                 310                 315                 320 


Ile Asp Cys Ser Pro His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe 
                325                 330                 335     


Pro Cys Leu Pro Lys Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val 
            340                 345                 350         


Phe Met Tyr Pro Glu Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn 
        355                 360                 365             


Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala Glu Asp Asn Leu Leu Ala 
    370                 375                 380                 


Leu Gly Leu Lys His Phe Glu Gly Thr Glu Phe Leu Asn Pro Leu Ile 
385                 390                 395                 400 


Ser Lys Tyr Leu Leu Thr Cys Lys Thr Ala Arg Gln Leu Thr Val Arg 
                405                 410                 415     


Ile Lys Asn Leu Asn Met Asn Arg Ala Pro Asp Asn Ile Ile Lys Phe 
            420                 425                 430         


Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu Gly Lys Cys Cys Glu Glu 
        435                 440                 445             


Ile Gln Pro His Gln Trp Lys Pro Pro Ile Glu Arg Glu Glu His Arg 
    450                 455                 460                 


Leu Pro Phe Trp Leu Lys Val Gln Pro Ser Ser Ser Lys Ser Val Gly 
465                 470                 475                 480 


Gly Arg Arg Ser Leu Lys Val Leu Arg Glu Tyr Gln Gly Leu Pro 
                485                 490                 495 


<210> 7139
<211> 59
<212> PRT
<213> Homo sapiens

<400> 7139
Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Val Ser Gly Ser Gly 
1               5                   10                  15      


Asn Trp Asp Gly Asn Ser Met Met Leu Met Ile Ile Thr Arg Arg Lys 
            20                  25                  30          


Ile Glu Gly Arg Trp Glu Lys Ala Tyr Arg Ser Met Thr Arg Thr Gly 
        35                  40                  45              


Phe His Gly Ser Val Thr Cys Met Thr Phe Tyr 
    50                  55                  


<210> 7140
<211> 68
<212> PRT
<213> Homo sapiens

<400> 7140
Met Gly Glu Thr Glu Gly Lys Lys Asp Glu Ala Asp Tyr Lys Arg Leu 
1               5                   10                  15      


Gln Thr Phe Pro Leu Val Arg His Ser Asp Met Pro Glu Glu Met Arg 
            20                  25                  30          


Val Glu Thr Met Glu Leu Cys Val Thr Ala Cys Glu Lys Phe Ser Asn 
        35                  40                  45              


Asn Asn Glu Val Leu Pro Ala Val Gln Ala Ala Pro Arg Ala Phe Asp 
    50                  55                  60                  


Gly Pro Cys Gly 
65              


<210> 7141
<211> 816
<212> PRT
<213> Homo sapiens

<400> 7141
Met Val Leu Met Phe Gln Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu 
1               5                   10                  15      


Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe 
            20                  25                  30          


Asn Arg Asp Pro Asn Leu Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro 
        35                  40                  45              


Glu Glu His Glu Leu Glu Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys 
    50                  55                  60                  


Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn Met Ser Thr 
65                  70                  75                  80  


Asp Leu Glu Gly Thr Asp Met Leu Ala Glu Lys Ala Asp Arg Arg Glu 
                85                  90                  95      


Tyr Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala Asp Lys Arg 
            100                 105                 110         


Ile Thr Pro Leu Lys Thr Leu Asn His Gln Phe Val Thr Met Thr His 
        115                 120                 125             


Leu Leu Asp Phe Pro His Ser Asn His Val Lys Ser Cys Phe Gln Asn 
    130                 135                 140                 


Met Glu Ile Cys Lys Arg Arg Val His Met Tyr Asp Thr Val Ser Gln 
145                 150                 155                 160 


Ile Lys Ser Pro Phe Thr Thr His Val Ala Pro Asn Thr Ser Thr Asn 
                165                 170                 175     


Leu Thr Met Ser Phe Ser Asn Gln Leu Asn Thr Val His Asn Gln Ala 
            180                 185                 190         


Ser Val Leu Ala Ser Ser Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu 
        195                 200                 205             


Ala Asn Ser Asp Val Ser Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro 
    210                 215                 220                 


Ser Ser Ala Ala Pro Val Pro Gly Val Ala Gln Gln Gly Val Ser Leu 
225                 230                 235                 240 


Gln Pro Gly Thr Thr Gln Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln 
                245                 250                 255     


Thr Phe Ile Val Cys Pro Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr 
            260                 265                 270         


Thr Lys His Ser Gly Phe Pro Val Arg Met Asp Asn Ala Val Pro Ile 
        275                 280                 285             


Val Pro Gln Ala Pro Ala Ala Gln Pro Leu Gln Ile Gln Ser Gly Val 
    290                 295                 300                 


Leu Thr Gln Gly Ser Cys Thr Pro Leu Met Val Ala Thr Leu His Pro 
305                 310                 315                 320 


Gln Val Ala Thr Ile Thr Pro Gln Tyr Ala Val Pro Phe Thr Leu Ser 
                325                 330                 335     


Cys Ala Ala Gly Arg Pro Ala Leu Val Glu Gln Thr Ala Ala Val Leu 
            340                 345                 350         


Gln Ala Trp Pro Gly Gly Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp 
        355                 360                 365             


Gln Gln Leu Pro Gly Val Ala Leu His Asn Ser Val Gln Pro Thr Ala 
    370                 375                 380                 


Met Ile Pro Glu Ala Met Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg 
385                 390                 395                 400 


Asn Ala His Ser His Gly Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro 
                405                 410                 415     


Ser Leu Leu Thr Asn His Val Thr Leu Ala Thr Ala Gln Pro Leu Asn 
            420                 425                 430         


Val Gly Val Ala His Val Val Arg Gln Gln Gln Ser Ser Ser Leu Pro 
        435                 440                 445             


Ser Lys Lys Asn Lys Gln Ser Ala Pro Val Ser Ser Lys Ser Ser Leu 
    450                 455                 460                 


Asp Val Leu Pro Ser Gln Val Tyr Ser Leu Val Gly Ser Ser Pro Leu 
465                 470                 475                 480 


Arg Thr Thr Ser Ser Tyr Asn Ser Leu Val Pro Val Gln Asp Gln His 
                485                 490                 495     


Gln Pro Ile Ile Ile Pro Asp Thr Pro Ser Pro Pro Val Ser Val Ile 
            500                 505                 510         


Thr Ile Arg Ser Asp Thr Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro 
        515                 520                 525             


Ser Ser Ser Gly Leu Lys Pro Arg Ser Asn Val Ile Ser Tyr Val Thr 
    530                 535                 540                 


Val Asn Asp Ser Pro Asp Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser 
545                 550                 555                 560 


Thr Asp Thr Leu Ser Ala Leu Arg Gly Asn Ser Gly Ser Val Leu Glu 
                565                 570                 575     


Gly Pro Gly Arg Val Val Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile 
            580                 585                 590         


Val Pro Pro Leu Lys Thr Gln Leu Gly Asp Cys Thr Val Ala Thr Gln 
        595                 600                 605             


Ala Ser Gly Leu Leu Ser Asn Lys Thr Lys Pro Val Ala Ser Val Ser 
    610                 615                 620                 


Gly Gln Ser Ser Gly Cys Cys Ile Thr Pro Thr Gly Tyr Arg Ala Gln 
625                 630                 635                 640 


Arg Gly Gly Thr Ser Ala Ala Gln Pro Leu Asn Leu Ser Gln Asn Gln 
                645                 650                 655     


Gln Ser Ser Ala Ala Pro Thr Ser Gln Glu Arg Ser Ser Asn Pro Ala 
            660                 665                 670         


Pro Arg Arg Gln Gln Ala Phe Val Ala Pro Leu Ser Gln Ala Pro Tyr 
        675                 680                 685             


Thr Phe Gln His Gly Ser Pro Leu His Ser Thr Gly His Pro His Leu 
    690                 695                 700                 


Ala Pro Ala Pro Ala His Leu Pro Ser Gln Ala His Leu Tyr Thr Tyr 
705                 710                 715                 720 


Ala Ala Pro Thr Ser Ala Ala Ala Leu Gly Ser Thr Ser Ser Ile Ala 
                725                 730                 735     


His Leu Phe Ser Pro Gln Gly Ser Ser Arg His Ala Ala Ala Tyr Thr 
            740                 745                 750         


Thr His Pro Ser Thr Leu Val His Gln Val Pro Val Ser Val Gly Pro 
        755                 760                 765             


Ser Leu Leu Thr Ser Ala Ser Val Ala Pro Ala Gln Tyr Gln His Gln 
    770                 775                 780                 


Phe Ala Thr Gln Ser Tyr Ile Gly Ser Ser Arg Gly Ser Thr Ile Tyr 
785                 790                 795                 800 


Thr Gly Tyr Pro Leu Ser Pro Thr Lys Ile Ser Gln Tyr Ser Tyr Leu 
                805                 810                 815     


<210> 7142
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7142
Met Asp Val Leu Ser Pro Leu Ser Phe Ile Lys Val Ser His Val Arg 
1               5                   10                  15      


Met Gln Gly Ile Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro 
            20                  25                  30          


Tyr Ile Gln Ile Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly 
        35                  40                  45              


Tyr Trp Gly Asn Lys Gly Gly Val Asn Ile Cys Leu Lys Leu Tyr Gly 
    50                  55                  60                  


Tyr Tyr Val Ser Ile Ile Asn Cys His Leu Pro Pro His Ile Ser Asn 
65                  70                  75                  80  


Asn Tyr Gln Arg Leu Glu His Phe Asp Arg Ile Leu Glu Met Gln Asn 
                85                  90                  95      


Cys Glu Gly Arg Asp Ile Pro Asn Ile Leu Asp His Asp Leu Ile Ile 
            100                 105                 110         


Trp Phe Gly Asp Met Asn Phe Arg Ile Glu Asp Phe Gly Leu His Phe 
        115                 120                 125             


Val Arg Glu Ser Ile Lys Asn Arg Cys Tyr Gly Gly Leu Trp Glu Lys 
    130                 135                 140                 


Asp Gln Leu Ser Ile Ala Lys Lys His Asp Pro Leu Leu Arg Glu Phe 
145                 150                 155                 160 


Gln Glu Gly Arg Leu Leu Phe Pro Pro Thr Tyr Lys Phe Asp Arg Asn 
                165                 170                 175     


Ser Asn Asp Tyr Asp Thr Ser Glu Lys Lys Arg Lys Pro Ala Trp Thr 
            180                 185                 190         


Asp Arg Ile Leu Trp Arg Leu Lys Arg Gln Pro Cys Ala Gly Pro Asp 
        195                 200                 205             


Thr Pro Ile Pro Pro Ala Ser His Phe Ser Leu Ser Leu Arg Gly Tyr 
    210                 215                 220                 


Ser Ser His Met Thr Tyr Gly Ile Ser Asp His Lys Pro Val Ser Gly 
225                 230                 235                 240 


Thr Phe Asp Leu Glu Leu Lys Pro Leu Val Ser Ala Pro Leu Ile Val 
                245                 250                 255     


Leu Met Pro Glu Asp Leu Trp Thr Val Glu Asn Asp Met Met Val Ser 
            260                 265                 270         


Tyr Ser Ser Thr Ser Asp Phe Pro Ser Ser Pro Trp Asp Trp Ile Gly 
        275                 280                 285             


Leu Tyr Lys Val Gly Leu Arg Asp Val Asn Asp Tyr Val Ser Tyr Ala 
    290                 295                 300                 


Trp Val Gly Asp Ser Lys Val Ser Cys Ser Asp Asn Leu Asn Gln Val 
305                 310                 315                 320 


Tyr Ile Asp Ile Ser Asn Ile Pro Thr Thr Glu Asp Glu Phe Leu Leu 
                325                 330                 335     


Cys Tyr Tyr Ser Asn Ser Leu Arg Ser Val Val Gly Ile Ser Arg Pro 
            340                 345                 350         


Phe Gln Ile Pro Pro Gly Ser Leu Arg Glu Asp Pro Leu Gly Glu Ala 
        355                 360                 365             


Gln Pro Gln Ile 
    370         


<210> 7143
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7143
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Val Arg Gly Pro Gln 
    130                 135                 140                 


Asn Asn Val Arg Ser Leu Gly Ile Ser Val Ser Ala Leu Val Ser 
145                 150                 155                 


<210> 7144
<211> 80
<212> PRT
<213> Homo sapiens

<400> 7144
Met Ala Ser Glu Glu Leu Gln Lys Asp Leu Glu Glu Val Lys Val Leu 
1               5                   10                  15      


Leu Glu Lys Ala Thr Arg Lys Arg Val Arg Asp Ala Leu Thr Ala Glu 
            20                  25                  30          


Lys Ser Lys Ile Glu Thr Glu Ile Lys Asn Lys Met Gln Gln Lys Ser 
        35                  40                  45              


Gln Lys Lys Ala Glu Leu Leu Asp Asn Glu Lys Pro Ala Ala Val Val 
    50                  55                  60                  


Ala Pro Ile Thr Thr Gly Tyr Thr Asp Gly Ile Ser Gln Ile Ser Leu 
65                  70                  75                  80  


<210> 7145
<211> 201
<212> PRT
<213> Homo sapiens

<400> 7145
Met Pro Ser Glu Thr Leu Trp Glu Ile Ala Lys Ala Glu Val Glu Lys 
1               5                   10                  15      


Arg Gly Ile Asn Gly Ser Glu Gly Asp Gly Ala Glu Ile Ala Glu Lys 
            20                  25                  30          


Phe Val Phe Phe Ile Gly Ser Lys Asn Gly Gly Lys Thr Thr Ile Ile 
        35                  40                  45              


Leu Arg Cys Leu Asp Arg Asp Glu Pro Pro Lys Pro Thr Leu Ala Leu 
    50                  55                  60                  


Glu Tyr Thr Tyr Gly Arg Arg Ala Lys Gly His Asn Thr Pro Lys Asp 
65                  70                  75                  80  


Ile Ala His Phe Trp Glu Leu Gly Gly Gly Thr Ser Leu Leu Asp Leu 
                85                  90                  95      


Ile Ser Ile Pro Ile Thr Gly Asp Thr Leu Arg Thr Phe Ser Leu Val 
            100                 105                 110         


Leu Val Leu Asp Leu Ser Lys Pro Asn Asp Leu Trp Pro Thr Met Glu 
        115                 120                 125             


Asn Leu Leu Gln Ala Thr Lys Ser His Val Asp Lys Val Ile Met Lys 
    130                 135                 140                 


Leu Gly Lys Thr Asn Ala Lys Ala Val Ser Glu Met Arg Gln Lys Ile 
145                 150                 155                 160 


Trp Asn Asn Met Pro Lys Asp His Pro Val Ser Cys Cys Leu Gly Leu 
                165                 170                 175     


Leu Leu Glu Ser Leu Val Pro Phe Ile Val Asn Asp Asn Ile Thr Asn 
            180                 185                 190         


Asn Phe Phe Arg Phe Leu Cys Met Thr 
        195                 200     


<210> 7146
<211> 466
<212> PRT
<213> Homo sapiens

<400> 7146
Met Ser Tyr Arg Pro Val Val Ser Pro Val Met Ser Leu Thr Arg Arg 
1               5                   10                  15      


Cys Met Arg Ser Arg Thr Ser Met Arg Thr Asp Ala Val Phe Leu Ile 
            20                  25                  30          


Leu Tyr Lys Glu Leu Tyr Tyr Arg His Ile Tyr Ala Lys Val Ser Gly 
        35                  40                  45              


Gly Pro Ser Leu Glu Gln Arg Phe Glu Ser Tyr Tyr Asn Tyr Cys Asn 
    50                  55                  60                  


Leu Phe Asn Tyr Ile Leu Asn Ala Asp Gly Pro Ala Pro Leu Glu Leu 
65                  70                  75                  80  


Pro Asn Gln Trp Leu Trp Asp Ile Ile Asp Glu Phe Ile Tyr Gln Phe 
                85                  90                  95      


Gln Ser Phe Ser Gln Tyr Arg Cys Lys Thr Ala Lys Lys Ser Glu Glu 
            100                 105                 110         


Glu Ile Asp Phe Leu Arg Ser Asn Pro Lys Ile Trp Asn Val His Ser 
        115                 120                 125             


Val Leu Asn Val Leu His Ser Leu Val Asp Lys Ser Asn Ile Asn Arg 
    130                 135                 140                 


Gln Leu Glu Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val Ala Gly 
145                 150                 155                 160 


Glu Tyr Gly Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe Ser Leu 
                165                 170                 175     


Val Gly Leu Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr Gln Ala 
            180                 185                 190         


Ile Lys Val Leu Glu Asn Ile Glu Leu Asn Lys Lys Ser Met Tyr Ser 
        195                 200                 205             


Arg Val Pro Glu Cys Gln Val Thr Thr Tyr Tyr Tyr Val Gly Phe Ala 
    210                 215                 220                 


Tyr Leu Met Met Arg Arg Tyr Gln Asp Ala Ile Arg Val Phe Ala Asn 
225                 230                 235                 240 


Ile Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln Arg Thr Thr 
                245                 250                 255     


Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met His Ala Leu 
            260                 265                 270         


Leu Ala Ile Ala Leu Thr Met Tyr Pro Met Arg Ile Asp Glu Ser Ile 
        275                 280                 285             


His Leu Gln Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg Met Gln 
    290                 295                 300                 


Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr Ser Cys Pro 
305                 310                 315                 320 


Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val His Pro Asn 
                325                 330                 335     


Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe Ser Asp Glu 
            340                 345                 350         


Val Gln Gln Gln Ala Gln Leu Ser Thr Ile Arg Ser Phe Leu Lys Leu 
        355                 360                 365             


Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp Leu Thr 
    370                 375                 380                 


Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His Lys Met Lys 
385                 390                 395                 400 


Asn Leu Val Trp Thr Ser Gly Ile Ser Ala Leu Asp Gly Glu Phe Gln 
                405                 410                 415     


Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met Ile His Ile 
            420                 425                 430         


Ala Asp Thr Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe Ile Arg Gln 
        435                 440                 445             


Ile His Lys Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met Gly Gln 
    450                 455                 460                 


Arg Pro 
465     


<210> 7147
<211> 198
<212> PRT
<213> Homo sapiens

<400> 7147
Met Ser Arg Ala Val Thr Ile Ala Glu Ala Phe Cys His Ile Leu Phe 
1               5                   10                  15      


Arg Ile Ile Ser Glu Ile Leu Met Arg Met Leu Glu Glu Gln Cys Leu 
            20                  25                  30          


Phe Pro Leu Pro Glu Pro Gln Asp Leu Phe Gln Ala Ser Gln Met Lys 
        35                  40                  45              


Phe Glu Asp Phe Gln Lys Asp Leu Arg Lys Leu Lys Lys Asp Leu Lys 
    50                  55                  60                  


Ala Cys Glu Val Glu Ala Gly Lys Val Tyr Gln Val Ser Ser Lys Glu 
65                  70                  75                  80  


His Met Gln Pro Phe Lys Glu Asn Met Glu Gln Phe Ile Ile Gln Ala 
                85                  90                  95      


Lys Ile Asp Gln Glu Ala Glu Glu Asn Ser Leu Thr Glu Thr His Lys 
            100                 105                 110         


Cys Phe Leu Glu Thr Thr Ala Tyr Phe Phe Met Lys Pro Lys Leu Gly 
        115                 120                 125             


Glu Lys Glu Val Ser Pro Asn Ala Phe Phe Ser Ile Trp His Glu Phe 
    130                 135                 140                 


Ser Ser Asp Phe Lys Asp Phe Trp Lys Lys Glu Asn Lys Leu Leu Leu 
145                 150                 155                 160 


Gln Glu Arg Val Lys Glu Ala Glu Glu Val Cys Arg Gln Lys Lys Gly 
                165                 170                 175     


Lys Ser Leu Tyr Lys Ile Lys Pro Arg His Asp Ser Gly Ile Lys Ala 
            180                 185                 190         


Lys Ile Ser Met Lys Thr 
        195             


<210> 7148
<211> 146
<212> PRT
<213> Homo sapiens

<400> 7148
Met Glu Pro Thr Arg Asp Cys Pro Leu Phe Gly Gly Ala Phe Ser Ala 
1               5                   10                  15      


Ile Leu Pro Met Gly Ala Ile Asp Val Ser Asp Leu Arg Pro Val Pro 
            20                  25                  30          


Asp Asn Gln Glu Val Phe Cys His Pro Val Thr Asp Gln Ser Leu Ile 
        35                  40                  45              


Val Glu Leu Leu Glu Leu Gln Ala His Val Arg Gly Glu Ala Ala Ala 
    50                  55                  60                  


Arg Tyr His Phe Glu Asp Val Gly Gly Val Gln Gly Ala Arg Ala Val 
65                  70                  75                  80  


His Val Glu Ser Val Gln Pro Leu Ser Leu Glu Asn Leu Ala Leu Arg 
                85                  90                  95      


Gly Arg Cys Gln Glu Ala Trp Val Leu Ser Gly Lys Gln Gln Ile Ala 
            100                 105                 110         


Lys Glu Asn Gln Gln Val Ala Lys Asp Val Thr Leu His Gln Ala Leu 
        115                 120                 125             


Leu Arg Leu Pro Gln Tyr Gln Thr Asp Leu Leu Leu Thr Phe Asn Gln 
    130                 135                 140                 


Pro Pro 
145     


<210> 7149
<211> 527
<212> PRT
<213> Homo sapiens

<400> 7149
Met Ser Leu Cys Gly Ala Arg Ala Asn Ala Lys Met Met Ala Ala Tyr 
1               5                   10                  15      


Asn Gly Gly Thr Ser Ala Ala Ala Ala Gly His His His His His His 
            20                  25                  30          


His His Leu Pro His Leu Pro Pro Pro His Leu His His His His His 
        35                  40                  45              


Pro Gln His His Leu His Pro Gly Ser Ala Ala Ala Val His Pro Val 
    50                  55                  60                  


Gln Gln His Thr Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Met Leu Asn Pro Gly Gln Gln Gln Pro Tyr Phe Pro Ser 
                85                  90                  95      


Pro Ala Pro Gly Gln Ala Pro Gly Pro Ala Ala Ala Ala Pro Ala Gln 
            100                 105                 110         


Val Gln Ala Ala Ala Ala Ala Thr Val Lys Ala His His His Gln His 
        115                 120                 125             


Ser His His Pro Gln Gln Gln Leu Asp Ile Glu Pro Asp Arg Pro Ile 
    130                 135                 140                 


Gly Tyr Gly Ala Phe Gly Val Val Trp Ser Val Thr Asp Pro Arg Asp 
145                 150                 155                 160 


Gly Lys Arg Val Ala Leu Lys Lys Met Pro Asn Val Phe Gln Asn Leu 
                165                 170                 175     


Val Ser Cys Lys Arg Val Phe Arg Glu Leu Lys Met Leu Cys Phe Phe 
            180                 185                 190         


Lys His Asp Asn Val Leu Ser Ala Leu Asp Ile Leu Gln Pro Pro His 
        195                 200                 205             


Ile Asp Tyr Phe Glu Glu Ile Tyr Val Val Thr Glu Leu Met Gln Ser 
    210                 215                 220                 


Asp Leu His Lys Ile Ile Val Ser Pro Gln Pro Leu Ser Ser Asp His 
225                 230                 235                 240 


Val Lys Val Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Leu His 
                245                 250                 255     


Ser Ala Gly Ile Leu His Arg Asp Ile Lys Pro Gly Asn Leu Leu Val 
            260                 265                 270         


Asn Ser Asn Cys Val Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val 
        275                 280                 285             


Glu Glu Leu Asp Glu Ser Arg His Met Thr Gln Glu Val Val Thr Gln 
    290                 295                 300                 


Tyr Tyr Arg Ala Pro Glu Ile Leu Met Gly Ser Arg His Tyr Ser Asn 
305                 310                 315                 320 


Ala Ile Asp Ile Trp Ser Val Gly Cys Ile Phe Ala Glu Leu Leu Gly 
                325                 330                 335     


Arg Arg Ile Leu Phe Gln Ala Gln Ser Pro Ile Gln Gln Leu Asp Leu 
            340                 345                 350         


Ile Thr Asp Leu Leu Gly Thr Pro Ser Leu Glu Ala Met Arg Thr Ala 
        355                 360                 365             


Cys Glu Gly Ala Lys Ala His Ile Leu Arg Gly Pro His Lys Gln Pro 
    370                 375                 380                 


Ser Leu Pro Val Leu Tyr Thr Leu Ser Ser Gln Ala Thr His Glu Ala 
385                 390                 395                 400 


Val His Leu Leu Cys Arg Met Leu Val Phe Asp Pro Ser Lys Arg Ile 
                405                 410                 415     


Ser Ala Lys Asp Ala Leu Ala His Pro Tyr Leu Asp Glu Gly Arg Leu 
            420                 425                 430         


Arg Tyr His Thr Cys Met Cys Lys Cys Cys Phe Ser Thr Ser Thr Gly 
        435                 440                 445             


Arg Val Tyr Thr Ser Asp Phe Glu Pro Val Thr Asn Pro Lys Phe Asp 
    450                 455                 460                 


Asp Thr Phe Glu Lys Asn Leu Ser Ser Val Arg Gln Val Lys Glu Ile 
465                 470                 475                 480 


Ile His Gln Phe Ile Leu Glu Gln Gln Lys Gly Asn Arg Val Pro Leu 
                485                 490                 495     


Cys Ile Asn Pro Gln Ser Ala Ala Phe Lys Ser Phe Ile Ser Ser Thr 
            500                 505                 510         


Val Ala Gln Pro Ser Glu Met Pro Pro Ser Pro Leu Val Trp Glu 
        515                 520                 525         


<210> 7150
<211> 913
<212> PRT
<213> Homo sapiens

<400> 7150
Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys 
1               5                   10                  15      


Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Glu Gln Ser Tyr 
            20                  25                  30          


Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Ala Tyr 
        35                  40                  45              


Ser Gly Thr Pro Leu Thr Glu Glu Lys Glu Lys Ile Val Trp Val Arg 
    50                  55                  60                  


Phe Glu Asn Ala Asp Leu Asn Asp Thr Ser Arg Asn Leu Glu Phe His 
65                  70                  75                  80  


Glu Ile His Ser Thr Gly Asn Glu Pro Pro Leu Leu Ile Met Ile Gly 
                85                  90                  95      


Tyr Ser Asp Gly Met Gln Val Trp Ser Ile Pro Ile Ser Gly Glu Ala 
            100                 105                 110         


Gln Glu Leu Phe Ser Val Arg His Gly Pro Ile Arg Ala Ala Arg Ile 
        115                 120                 125             


Leu Pro Ala Pro Gln Phe Gly Ala Gln Lys Cys Asp Asn Phe Ala Glu 
    130                 135                 140                 


Lys Arg Pro Leu Leu Gly Val Cys Lys Ser Ile Gly Ser Ser Gly Thr 
145                 150                 155                 160 


Ser Pro Pro Tyr Cys Cys Val Asp Leu Tyr Ser Leu Arg Thr Gly Glu 
                165                 170                 175     


Met Val Lys Ser Ile Gln Phe Lys Thr Pro Ile Tyr Asp Leu His Cys 
            180                 185                 190         


Asn Lys Arg Ile Leu Val Val Val Leu Gln Glu Lys Ile Ala Ala Phe 
        195                 200                 205             


Asp Ser Cys Thr Phe Thr Lys Lys Phe Phe Val Thr Ser Cys Tyr Pro 
    210                 215                 220                 


Cys Pro Gly Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu 
225                 230                 235                 240 


Ala Tyr Ala Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly 
                245                 250                 255     


Ala Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala 
            260                 265                 270         


Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr 
        275                 280                 285             


Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala 
    290                 295                 300                 


Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr 
305                 310                 315                 320 


Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu 
                325                 330                 335     


Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys 
            340                 345                 350         


Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr 
        355                 360                 365             


Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His 
    370                 375                 380                 


Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His 
385                 390                 395                 400 


Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp 
                405                 410                 415     


Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe 
            420                 425                 430         


Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser 
        435                 440                 445             


Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu 
    450                 455                 460                 


Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser 
465                 470                 475                 480 


Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly 
                485                 490                 495     


Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro 
            500                 505                 510         


Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro 
        515                 520                 525             


Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg 
    530                 535                 540                 


Thr Gly Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met 
545                 550                 555                 560 


Gly Gly Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp 
                565                 570                 575     


Phe Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln 
            580                 585                 590         


Val Val Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val 
        595                 600                 605             


Glu His Met Met Glu Pro Arg Pro Leu Ser Thr Ala Pro Lys Ile Ser 
    610                 615                 620                 


Asp Asp Thr Pro Leu Glu Met Met Thr Ser Pro Arg Ala Ser Trp Thr 
625                 630                 635                 640 


Leu Val Arg Thr Pro Gln Trp Asn Glu Leu Gln Pro Pro Phe Asn Ala 
                645                 650                 655     


Asn His Pro Leu Leu Leu Ala Ala Asp Ala Val Gln Tyr Tyr Gln Phe 
            660                 665                 670         


Leu Leu Ala Gly Leu Val Pro Pro Gly Ser Pro Gly Pro Ile Thr Arg 
        675                 680                 685             


His Gly Ser Tyr Asp Ser Leu Ala Ser Asp His Ser Gly Gln Glu Asp 
    690                 695                 700                 


Glu Glu Trp Leu Ser Gln Val Glu Ile Val Thr His Thr Gly Pro His 
705                 710                 715                 720 


Arg Arg Leu Trp Met Gly Pro Gln Phe Gln Phe Lys Thr Ile His Pro 
                725                 730                 735     


Ser Gly Gln Thr Thr Val Ile Ser Ser Ser Ser Ser Val Leu Gln Ser 
            740                 745                 750         


His Gly Pro Ser Asp Thr Pro Gln Pro Leu Leu Asp Phe Asp Thr Asp 
        755                 760                 765             


Asp Leu Asp Leu Asn Ser Leu Arg Ile Gln Pro Val Arg Ser Asp Pro 
    770                 775                 780                 


Val Ser Met Pro Gly Ser Ser Arg Pro Val Ser Asp Arg Arg Gly Val 
785                 790                 795                 800 


Ser Thr Val Ile Asp Ala Ala Ser Gly Thr Phe Asp Arg Ser Val Thr 
                805                 810                 815     


Leu Leu Glu Val Cys Gly Ser Trp Pro Glu Gly Phe Gly Leu Arg His 
            820                 825                 830         


Met Ser Ser Met Glu His Thr Glu Glu Gly Leu Arg Glu Arg Leu Ala 
        835                 840                 845             


Asp Ala Met Ala Glu Ser Pro Ser Arg Asp Val Val Gly Ser Gly Thr 
    850                 855                 860                 


Glu Leu Gln Arg Glu Gly Ser Ile Glu Thr Leu Ser Asn Ser Ser Gly 
865                 870                 875                 880 


Ser Thr Ser Gly Ser Ile Pro Arg Asn Phe Asp Gly Tyr Arg Ser Pro 
                885                 890                 895     


Leu Pro Thr Asn Glu Ser Gln Pro Leu Ser Leu Phe Pro Thr Gly Phe 
            900                 905                 910         


Pro 
    


<210> 7151
<211> 719
<212> PRT
<213> Homo sapiens

<400> 7151
Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg 
1               5                   10                  15      


Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe 
            20                  25                  30          


Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys 
        35                  40                  45              


Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln 
    50                  55                  60                  


Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys Glu Val His Gln Thr 
65                  70                  75                  80  


Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln 
                85                  90                  95      


Gln His Val Gln Leu Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn 
            100                 105                 110         


Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu 
        115                 120                 125             


Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn 
    130                 135                 140                 


Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met 
145                 150                 155                 160 


Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro 
                165                 170                 175     


His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys 
            180                 185                 190         


Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu 
        195                 200                 205             


Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile 
    210                 215                 220                 


Leu Phe Thr Lys Ala Glu Asp Asn Lys Tyr Leu Leu Thr Cys Lys Thr 
225                 230                 235                 240 


Ala Arg Gln Leu Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala 
                245                 250                 255     


Pro Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val 
            260                 265                 270         


Leu Gly Lys Cys Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro 
        275                 280                 285             


Ile Glu Arg Glu Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu 
    290                 295                 300                 


Pro Ser Ile Gln Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu 
305                 310                 315                 320 


Val Gly Asn Met Thr Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu 
                325                 330                 335     


Glu Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu 
            340                 345                 350         


Leu Pro Lys Gly Val Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe 
        355                 360                 365             


Pro Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu 
    370                 375                 380                 


Leu Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys 
385                 390                 395                 400 


Thr Pro Ala Gln Ser Thr His Ser Glu Ala Pro Pro Ser Lys Met Val 
                405                 410                 415     


Leu Arg Ile Pro His Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val 
            420                 425                 430         


Pro Gly Val Pro Pro Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser 
        435                 440                 445             


Pro Ala Ala Leu Pro Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val 
465                 470                 475                 480 


Met Met Pro Ser Pro Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg 
                485                 490                 495     


Arg Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys 
            500                 505                 510         


Pro Ala Pro Val Ile His Pro Ala Ser Val Ile Phe Thr Val Pro Ala 
        515                 520                 525             


Thr Thr Val Lys Ile Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln 
    530                 535                 540                 


Pro Val Asn Ala Ala Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala 
545                 550                 555                 560 


Thr Leu Leu Val Asn Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro 
                565                 570                 575     


Leu Val Ala Ser Ser Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val 
            580                 585                 590         


Asn Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys Ala His Met Asn Val 
        595                 600                 605             


Asp Ile Ala Cys Ala Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu 
    610                 615                 620                 


Glu Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val 
625                 630                 635                 640 


Phe Pro Lys Val Glu His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln 
                645                 650                 655     


Cys Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val 
            660                 665                 670         


Lys Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile 
        675                 680                 685             


Gln Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val 
    690                 695                 700                 


Lys Met Glu Pro Glu Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
705                 710                 715                 


<210> 7152
<211> 107
<212> PRT
<213> Homo sapiens

<400> 7152
Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn Thr Ala 
1               5                   10                  15      


Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln Leu Ala 
            20                  25                  30          


Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu 
        35                  40                  45              


Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp 
    50                  55                  60                  


Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn 
65                  70                  75                  80  


Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys 
                85                  90                  95      


Val Cys Phe Leu Ala Thr Gly Gly Gly Arg Leu 
            100                 105         


<210> 7153
<211> 532
<212> PRT
<213> Homo sapiens

<400> 7153
Met Phe Val Leu Gly Ile Pro Leu Cys Pro Ala Leu Ser Phe Ser Gly 
1               5                   10                  15      


Gly Asp Asp Ser Gln Thr Gln Leu Phe Val Ser Ser Lys Asp Val Ile 
            20                  25                  30          


Lys Glu Ile Glu Asp Phe Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly 
        35                  40                  45              


Asn Thr Val Gly Val Glu Ala Ala Arg Val Ile Ala Lys Ala Leu Glu 
    50                  55                  60                  


Lys Lys Ser Glu Leu Lys Arg Cys His Trp Ser Asp Met Phe Thr Gly 
65                  70                  75                  80  


Arg Leu Arg Thr Glu Ile Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly 
                85                  90                  95      


Leu Ile Thr Ala Gly Ala Gln Leu Val Glu Leu Asp Leu Ser Asp Asn 
            100                 105                 110         


Ala Phe Gly Pro Asp Gly Val Gln Gly Phe Glu Ala Leu Leu Lys Ser 
        115                 120                 125             


Ser Ala Cys Phe Thr Leu Gln Glu Leu Lys Leu Asn Asn Cys Gly Met 
    130                 135                 140                 


Gly Ile Gly Gly Gly Lys Val Ile Gly Thr Leu Glu Glu Val His Met 
145                 150                 155                 160 


Pro Gln Asn Gly Ile Asn His Pro Gly Ile Thr Ala Leu Ala Gln Ala 
                165                 170                 175     


Phe Ala Val Asn Pro Leu Leu Arg Val Ile Asn Leu Asn Asp Asn Thr 
            180                 185                 190         


Phe Thr Glu Lys Gly Ala Val Ala Met Ala Glu Thr Leu Lys Thr Leu 
        195                 200                 205             


Arg Gln Val Glu Val Ile Asn Phe Gly Asp Cys Leu Val Arg Ser Lys 
    210                 215                 220                 


Gly Ala Val Ala Ile Ala Asp Ala Ile Arg Gly Gly Leu Pro Lys Leu 
225                 230                 235                 240 


Lys Glu Leu Asn Leu Ser Phe Cys Glu Ile Lys Arg Asp Ala Ala Leu 
                245                 250                 255     


Ala Val Ala Glu Ala Met Ala Asp Lys Ala Glu Leu Glu Lys Leu Asp 
            260                 265                 270         


Leu Asn Gly Asn Thr Leu Gly Glu Glu Gly Cys Glu Gln Leu Gln Glu 
        275                 280                 285             


Val Leu Glu Gly Phe Asn Met Ala Lys Val Leu Ala Ser Leu Ser Asp 
    290                 295                 300                 


Asp Glu Asp Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Ala Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu 
                325                 330                 335     


Glu Glu Glu Glu Glu Glu Pro Gln Gln Arg Gly Gln Gly Glu Lys Ser 
            340                 345                 350         


Ala Thr Pro Ser Arg Lys Ile Leu Asp Pro Asn Thr Gly Glu Pro Ala 
        355                 360                 365             


Pro Val Leu Ser Ser Pro Pro Pro Ala Asp Val Ser Thr Phe Leu Ala 
    370                 375                 380                 


Phe Pro Ser Pro Glu Lys Leu Leu Arg Leu Gly Pro Lys Ser Ser Val 
385                 390                 395                 400 


Leu Ile Ala Gln Gln Thr Asp Thr Ser Asp Pro Glu Lys Val Val Ser 
                405                 410                 415     


Ala Phe Leu Lys Val Ser Ser Val Phe Lys Asp Glu Ala Thr Val Arg 
            420                 425                 430         


Met Ala Val Gln Asp Ala Val Asp Ala Leu Met Gln Lys Ala Phe Asn 
        435                 440                 445             


Ser Ser Ser Phe Asn Ser Asn Thr Phe Leu Thr Arg Leu Leu Val His 
    450                 455                 460                 


Met Gly Leu Leu Lys Ser Glu Asp Lys Val Lys Ala Ile Ala Asn Leu 
465                 470                 475                 480 


Tyr Gly Pro Leu Met Ala Leu Asn His Met Val Gln Gln Asp Tyr Phe 
                485                 490                 495     


Pro Lys Ala Leu Ala Pro Leu Leu Leu Ala Phe Val Thr Lys Pro Asn 
            500                 505                 510         


Ser Ala Leu Glu Ser Cys Ser Phe Ala Arg His Ser Leu Leu Gln Thr 
        515                 520                 525             


Leu Tyr Lys Val 
    530         


<210> 7154
<211> 460
<212> PRT
<213> Homo sapiens

<400> 7154
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg Cys Thr Leu 
        115                 120                 125             


Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu Asn Val Glu 
    130                 135                 140                 


Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu Gln Arg Glu 
145                 150                 155                 160 


Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu Lys Leu Asp 
                165                 170                 175     


Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln Lys Thr Ala 
            180                 185                 190         


Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu Glu Glu His 
        195                 200                 205             


Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Leu Gln Thr Gly Leu 
    210                 215                 220                 


Glu Ile Ser Lys Ile Ile Met Ser Ser Val Ser Asn Leu Lys His Ser 
225                 230                 235                 240 


Lys Glu Lys Lys Lys Ser Ser Lys Lys Thr Lys Cys Ile Lys Arg Arg 
                245                 250                 255     


Pro Pro Trp Gln Ile Cys Ser Lys Phe Gly Ala Leu Pro Phe Val Ala 
            260                 265                 270         


Glu Lys Met Arg Gln His Arg Asp Pro His Ile Leu Gln Lys Pro Phe 
        275                 280                 285             


Asn Val Thr Glu Thr Arg Cys Leu Pro Lys Pro Ser Arg Thr Thr Ser 
    290                 295                 300                 


Trp Cys Lys Ala Ile Pro Pro Asp Ser Glu Lys Ser Ile Ser Ile Cys 
305                 310                 315                 320 


Asp Asn Leu Ser Glu Leu Leu Met Ala Met Gln Asp Glu Leu Asp Gln 
                325                 330                 335     


Met Ser Met Glu His Gln Glu Leu Leu Lys Gln Met Lys Glu Thr Glu 
            340                 345                 350         


Ser His Ser Val Cys Asp Asp Ile Glu Cys Glu Leu Glu Cys Leu Leu 
        355                 360                 365             


Lys Lys Met Glu Ile Lys Gly Glu Gln Ile Ser Lys Leu Lys Lys His 
    370                 375                 380                 


Gln Asp Ser Val Cys Lys Leu Gln Gln Lys Val Gln Asn Ser Lys Met 
385                 390                 395                 400 


Ser Glu Ala Ser Gly Ile Gln Gln Glu Asp Ser Tyr Pro Lys Gly Ser 
                405                 410                 415     


Lys Asn Ile Lys Asn Ser Pro Arg Lys Cys Leu Thr Asp Thr Asn Leu 
            420                 425                 430         


Phe Gln Lys Asn Ser Ser Phe His Pro Ile Arg Val His Asn Leu Gln 
        435                 440                 445             


Met Lys Leu Arg Arg Asp Asp Ile Met Trp Glu Gln 
    450                 455                 460 


<210> 7155
<211> 188
<212> PRT
<213> Homo sapiens

<400> 7155
Met Thr Ala Pro Ser Cys Ala Phe Pro Val Gln Phe Arg Gln Pro Ser 
1               5                   10                  15      


Val Ser Gly Leu Ser Gln Ile Thr Lys Ser Leu Tyr Ile Ser Asn Gly 
            20                  25                  30          


Val Ala Ala Asn Asn Lys Leu Met Leu Ser Ser Asn Gln Ile Thr Met 
        35                  40                  45              


Val Ile Asn Val Ser Val Glu Val Val Asn Thr Leu Tyr Glu Asp Ile 
    50                  55                  60                  


Gln Tyr Met Gln Val Pro Val Ala Asp Ser Pro Asn Ser Arg Leu Cys 
65                  70                  75                  80  


Asp Phe Phe Asp Pro Ile Ala Asp His Ile His Ser Val Glu Met Lys 
                85                  90                  95      


Gln Gly Arg Thr Leu Leu His Cys Ala Ala Gly Val Ser Arg Ser Ala 
            100                 105                 110         


Ala Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ala Met Ser Leu Leu 
        115                 120                 125             


Asp Ala His Thr Trp Thr Lys Ser Cys Arg Pro Ile Ile Arg Pro Asn 
    130                 135                 140                 


Ser Gly Phe Trp Glu Gln Leu Ile His Tyr Glu Phe Gln Leu Phe Gly 
145                 150                 155                 160 


Lys Asn Thr Val His Met Val Ser Ser Pro Val Gly Met Ile Pro Asp 
                165                 170                 175     


Ile Tyr Glu Lys Glu Val Arg Leu Met Ile Pro Leu 
            180                 185             


<210> 7156
<211> 531
<212> PRT
<213> Homo sapiens

<400> 7156
Met Asn Lys Thr Asn Gln Val Tyr Ala Ala Asn Glu Asp His Asn Ser 
1               5                   10                  15      


Gln Phe Ile Asp Asp Tyr Ser Ser Ser Asp Glu Ser Leu Ser Val Ser 
            20                  25                  30          


His Phe Ser Phe Ser Lys Gln Ser His Arg Pro Arg Thr Ile Arg Asp 
        35                  40                  45              


Arg Thr Ser Phe Ser Ser Lys Leu Pro Ser His Asn Lys Lys Asn Ser 
    50                  55                  60                  


Thr Phe Ile Pro Arg Lys Pro Met Lys Cys Ser Asn Glu Lys Val Val 
65                  70                  75                  80  


Asn Gln Glu Gln Ser Tyr Glu Ser Met Asp Lys Phe Leu Asp Gly Val 
                85                  90                  95      


Gln Glu Val Ala Tyr Ile His Ser Asn Gln Asn Val Ile Gly Ser Ser 
            100                 105                 110         


Lys Ala Glu Asn His Met Ser Arg Trp Ala Ala His Asp Val Phe Glu 
        115                 120                 125             


Leu Lys Gln Phe Ser Gln Leu Pro Ala Asn Ile Ala Val Cys Ser Ser 
    130                 135                 140                 


Lys Thr Tyr Lys Glu Lys Val Asp Ala Asp Thr Leu Pro His Thr Lys 
145                 150                 155                 160 


Lys Gly Gln Gln Pro Ser Glu Gly Ser Ile Ser Leu Pro Leu Tyr Ile 
                165                 170                 175     


Ser Asn Pro Val Asn Gln Lys Lys Lys Lys Val Tyr His Thr Asn Gln 
            180                 185                 190         


Thr Thr Phe Ile Ile Gly Glu Thr Pro Lys Gly Ile Arg Arg Lys Gln 
        195                 200                 205             


Phe Glu Glu Met Ala Ser Tyr Phe Asn Ser Ser Ser Val Asn Glu Phe 
    210                 215                 220                 


Ala Lys His Ile Thr Asn Ala Thr Ser Glu Glu Arg Gln Lys Met Leu 
225                 230                 235                 240 


Arg Asp Phe Tyr Ala Ser Gln Tyr Pro Glu Val Lys Glu Phe Phe Val 
                245                 250                 255     


Asp Ser Val Ser Gln Phe Asn Asn Ser Ser Phe Glu Lys Gly Glu Gln 
            260                 265                 270         


Arg Thr Arg Lys Lys Ser Asp Lys Arg Glu Ser Leu Ile Lys Pro Arg 
        275                 280                 285             


Leu Ser Asp Ser Glu Thr Leu Ser Phe Lys Asp Ser Thr Asn Lys Ile 
    290                 295                 300                 


Ser Gln Val Cys Ser Leu Lys Thr Tyr Lys Arg Lys Ser Val Lys Phe 
305                 310                 315                 320 


Gln Asn His Ile Ser Tyr Arg Glu Glu Val Phe Phe Asn Asp Ala Glu 
                325                 330                 335     


Thr Lys Lys Ser Pro Val Ser Ser Thr Gln Glu Ile Asp Ser Gly Lys 
            340                 345                 350         


Asn Ser Gln Ala Ser Glu Asp Thr Val Thr Ser Arg Ser Leu Asn Ser 
        355                 360                 365             


Glu Ser Glu Thr Arg Glu Arg Arg Leu Glu Asn Thr Met Lys Asp Gln 
    370                 375                 380                 


Gln Asp Leu Thr Arg Thr Gly Ile Ser Arg Lys Glu Pro Leu Leu Lys 
385                 390                 395                 400 


Leu Glu Asn Lys Lys Ile Glu Asn Pro Val Leu Glu Asn Thr Ser Val 
                405                 410                 415     


Ile Ser Leu Leu Gly Asp Thr Ser Ile Leu Asp Asp Leu Phe Lys Ser 
            420                 425                 430         


His Gly Asn Ser Pro Thr Gln Leu Pro Lys Lys Val Leu Ser Gly Pro 
        435                 440                 445             


Met Glu Lys Ala Lys Gln Arg Pro Lys Asp Phe Trp Asp Ile Leu Asn 
    450                 455                 460                 


Glu Gln Asn Asp Glu Ser Leu Ser Lys Leu Thr Asp Leu Ala Val Ile 
465                 470                 475                 480 


Glu Thr Leu Cys Glu Lys Ala Pro Leu Ala Ala Pro Phe Lys Arg Arg 
                485                 490                 495     


Glu Glu Pro Ala Thr Ser Leu Trp Lys Ser Asn Glu Lys Phe Leu Trp 
            500                 505                 510         


Lys Lys Phe Ser Pro Ser Asp Thr Asp Glu Asn Ala Thr Asn Thr Gln 
        515                 520                 525             


Ser Thr Thr 
    530     


<210> 7157
<211> 362
<212> PRT
<213> Homo sapiens

<400> 7157
Met Thr Gly His Thr Arg Ser Ser Leu Pro Arg Cys Thr Gly Ile Val 
1               5                   10                  15      


Leu Leu Ile Lys Leu Arg Phe Ser Glu Arg Leu Thr Gly His Leu His 
            20                  25                  30          


Ala Gln Gly Thr Pro Pro Tyr Val Ile Asn Leu Asp Pro Ala Val His 
        35                  40                  45              


Glu Val Pro Phe Pro Ala Asn Ile Asp Ile Arg Asp Thr Val Lys Tyr 
    50                  55                  60                  


Lys Glu Val Met Lys Gln Tyr Gly Leu Gly Pro Asn Gly Gly Ile Val 
65                  70                  75                  80  


Thr Ser Leu Asn Leu Phe Ala Thr Arg Phe Asp Gln Val Met Lys Phe 
                85                  90                  95      


Ile Glu Lys Ala Gln Asn Met Ser Lys Tyr Val Leu Ile Asp Thr Pro 
            100                 105                 110         


Gly Gln Ile Glu Val Phe Thr Trp Ser Ala Ser Gly Thr Ile Ile Thr 
        115                 120                 125             


Glu Ala Leu Ala Ser Ser Phe Pro Thr Val Val Ile Tyr Val Met Asp 
    130                 135                 140                 


Thr Ser Arg Ser Thr Asn Pro Val Thr Phe Met Ser Asn Met Leu Tyr 
145                 150                 155                 160 


Ala Cys Ser Ile Leu Tyr Lys Thr Lys Leu Pro Phe Ile Val Val Met 
                165                 170                 175     


Asn Lys Thr Asp Ile Ile Asp His Ser Phe Ala Val Glu Trp Met Gln 
            180                 185                 190         


Asp Phe Glu Ala Phe Gln Asp Ala Leu Asn Gln Glu Thr Thr Tyr Val 
        195                 200                 205             


Ser Asn Leu Thr Arg Ser Met Ser Leu Val Leu Asp Glu Phe Tyr Ser 
    210                 215                 220                 


Ser Leu Arg Val Val Gly Val Ser Ala Val Leu Gly Thr Gly Leu Asp 
225                 230                 235                 240 


Glu Leu Phe Val Gln Val Thr Ser Ala Ala Glu Glu Tyr Glu Arg Glu 
                245                 250                 255     


Tyr Arg Pro Glu Tyr Glu Arg Leu Lys Lys Ser Leu Ala Asn Ala Glu 
            260                 265                 270         


Ser Gln Gln Gln Arg Glu Gln Leu Glu Arg Leu Arg Lys Asp Met Gly 
        275                 280                 285             


Ser Val Ala Leu Asp Ala Gly Thr Ala Lys Asp Ser Leu Ser Pro Val 
    290                 295                 300                 


Leu His Pro Ser Asp Leu Ile Leu Thr Arg Gly Thr Leu Asp Glu Glu 
305                 310                 315                 320 


Asp Glu Glu Ala Asp Ser Asp Thr Asp Asp Ile Asp His Arg Val Thr 
                325                 330                 335     


Glu Glu Ser His Glu Glu Pro Ala Phe Gln Asn Phe Met Gln Glu Ser 
            340                 345                 350         


Met Ala Gln Tyr Trp Lys Arg Asn Asn Lys 
        355                 360         


<210> 7158
<211> 445
<212> PRT
<213> Homo sapiens

<400> 7158
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 
145                 150                 155                 160 


Ala Ala Cys Lys Glu Glu Lys Leu Ala Ile Ser Arg Glu Ala Asn Ser 
                165                 170                 175     


Lys Ala Asp Pro Ser Leu Asn Pro Glu Gln Leu Lys Lys Leu Gln Asp 
            180                 185                 190         


Lys Ile Glu Lys Cys Lys Gln Asp Val Leu Lys Thr Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ser Leu Lys Glu Leu Asp Gln Gly Thr Pro Gln Tyr Met Glu 
    210                 215                 220                 


Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys Arg 
225                 230                 235                 240 


Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gln Lys His Leu Asp 
                245                 250                 255     


Leu Ser Asn Val Ala Gly Tyr Lys Ala Ile Tyr His Asp Leu Glu Gln 
            260                 265                 270         


Ser Ile Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala 
        275                 280                 285             


Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp 
    290                 295                 300                 


Ser Ala Asp Leu Asn Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 
305                 310                 315                 320 


Thr Asp Gly Val Thr Leu Thr Gly Ile Asn Gln Thr Gly Asp Gln Ser 
                325                 330                 335     


Leu Pro Ser Lys Pro Ser Ser Val Ser Ser Tyr Glu Lys Thr Gln Ser 
            340                 345                 350         


Tyr Pro Thr Asp Trp Ser Asp Asp Glu Ser Asn Asn Pro Phe Ser Ser 
        355                 360                 365             


Thr Asp Ala Asn Gly Asp Ser Asn Pro Phe Asp Asp Asp Ala Thr Ser 
    370                 375                 380                 


Gly Thr Glu Val Arg Val Arg Ala Leu Tyr Asp Tyr Glu Gly Gln Glu 
385                 390                 395                 400 


His Asp Glu Leu Ser Phe Lys Ala Gly Asp Glu Leu Thr Lys Met Glu 
                405                 410                 415     


Asp Glu Asp Glu Gln Gly Trp Cys Lys Gly Arg Leu Asp Asn Gly Gln 
            420                 425                 430         


Val Gly Leu Tyr Pro Ala Asn Tyr Val Glu Ala Ile Gln 
        435                 440                 445 


<210> 7159
<211> 134
<212> PRT
<213> Homo sapiens

<400> 7159
Met Ser Glu Asn Ala Ala Pro Gly Leu Ile Ser Glu Leu Leu Leu Gln 
1               5                   10                  15      


Arg Gly Thr Thr Lys Val Ala Thr Gly Leu Val Leu Asn Arg Asp Gln 
            20                  25                  30          


Arg Leu Ala Trp Ala Glu Asn Ser Ile Asp Phe Ile Ser Arg Glu Leu 
        35                  40                  45              


Cys Ala His Ser Ile Arg Lys Leu Gln Ala His Val Leu Leu Ile Lys 
    50                  55                  60                  


Ala Val His Gly Tyr Phe Asp Ser Arg Gln Asn Tyr Ser Glu Lys Glu 
65                  70                  75                  80  


Ser Leu Ser Phe Met Ile Asp Thr Met Lys Ser Thr Leu Lys Glu Gln 
                85                  90                  95      


Phe Gln Phe Val Glu Val Pro Gly Asn His Cys Val His Met Ser Glu 
            100                 105                 110         


Pro Gln His Val Ala Ser Ile Ile Ser Ser Phe Leu Gln Cys Thr His 
        115                 120                 125             


Met Leu Pro Ala Gln Leu 
    130                 


<210> 7160
<211> 106
<212> PRT
<213> Homo sapiens

<400> 7160
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Thr Glu Ser 
    50                  55                  60                  


Arg Gly Thr Asp Thr Glu Ser Ser Gly Glu Asp Lys Asp Ser Asp Ser 
65                  70                  75                  80  


Met Glu Asp Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His 
                85                  90                  95      


Asp Arg Ser Glu Glu Glu Glu Glu Glu Glu 
            100                 105     


<210> 7161
<211> 329
<212> PRT
<213> Homo sapiens

<400> 7161
Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Gly Lys Ile Gln Tyr Lys Glu Tyr Ile Ile Glu 
    290                 295                 300                 


Gly Phe Glu Asn Met Pro Ala Ala Phe Met Gly Met Leu Lys Gly Asp 
305                 310                 315                 320 


Asn Leu Gly Lys Thr Ile Val Lys Ala 
                325                 


<210> 7162
<211> 744
<212> PRT
<213> Homo sapiens

<400> 7162
Met Ala Thr Ala Asn Phe Gly Lys Ile Gln Ile Gly Ile Tyr Val Glu 
1               5                   10                  15      


Ile Lys Arg Ser Asp Gly Arg Ile His Gln Ala Met Val Thr Ser Leu 
            20                  25                  30          


Asn Glu Asp Asn Glu Ser Val Thr Val Glu Trp Ile Glu Asn Gly Asp 
        35                  40                  45              


Thr Lys Gly Lys Glu Ile Asp Leu Glu Ser Ile Phe Ser Leu Asn Pro 
    50                  55                  60                  


Asp Leu Val Pro Asp Glu Glu Ile Glu Pro Ser Pro Glu Thr Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Ser Ser Ala Lys Val Asn Lys Ile Val Lys Asn Arg Arg 
                85                  90                  95      


Thr Val Ala Ser Ile Lys Asn Asp Pro Pro Ser Arg Asp Asn Arg Val 
            100                 105                 110         


Val Gly Ser Ala Arg Ala Arg Pro Ser Gln Phe Pro Glu Gln Ser Ser 
        115                 120                 125             


Ser Ala Gln Gln Asn Gly Ser Val Ser Asp Ile Ser Pro Val Gln Ala 
    130                 135                 140                 


Ala Lys Lys Glu Phe Gly Pro Pro Ser Arg Arg Lys Ser Asn Cys Val 
145                 150                 155                 160 


Lys Glu Val Glu Lys Leu Gln Glu Lys Arg Glu Lys Arg Arg Leu Gln 
                165                 170                 175     


Gln Gln Glu Leu Arg Glu Lys Arg Ala Gln Asp Val Asp Ala Thr Asn 
            180                 185                 190         


Pro Asn Tyr Glu Ile Met Cys Met Ile Arg Asp Phe Arg Gly Ser Leu 
        195                 200                 205             


Asp Tyr Arg Pro Leu Thr Thr Ala Asp Pro Ile Asp Glu His Arg Ile 
    210                 215                 220                 


Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Lys Glu Thr Gln Met 
225                 230                 235                 240 


Lys Asp Leu Asp Val Ile Thr Ile Pro Ser Lys Asp Val Val Met Val 
                245                 250                 255     


His Glu Pro Lys Gln Lys Val Asp Leu Thr Arg Tyr Leu Glu Asn Gln 
            260                 265                 270         


Thr Phe Arg Phe Asp Tyr Ala Phe Asp Asp Ser Ala Pro Asn Glu Met 
        275                 280                 285             


Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Glu Thr Ile Phe Glu Arg 
    290                 295                 300                 


Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr 
305                 310                 315                 320 


His Thr Met Gly Gly Asp Phe Ser Gly Lys Asn Gln Asp Cys Ser Lys 
                325                 330                 335     


Gly Ile Tyr Ala Leu Ala Ala Arg Asp Val Phe Leu Met Leu Lys Lys 
            340                 345                 350         


Pro Asn Tyr Lys Lys Leu Glu Leu Gln Val Tyr Ala Thr Phe Phe Glu 
        355                 360                 365             


Ile Tyr Ser Gly Lys Val Phe Asp Leu Leu Asn Arg Lys Thr Lys Leu 
    370                 375                 380                 


Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val Gly Leu Gln 
385                 390                 395                 400 


Glu Arg Glu Val Lys Cys Val Glu Asp Val Leu Lys Leu Ile Asp Ile 
                405                 410                 415     


Gly Asn Ser Cys Arg Thr Ser Gly Gln Thr Ser Ala Asn Ala His Ser 
            420                 425                 430         


Ser Arg Ser His Ala Val Phe Gln Ile Ile Leu Arg Arg Lys Gly Lys 
        435                 440                 445             


Leu His Gly Lys Phe Ser Leu Ile Asp Leu Ala Gly Asn Glu Arg Gly 
    450                 455                 460                 


Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Leu Glu Gly Ala Glu 
465                 470                 475                 480 


Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg Ala Leu Gly 
                485                 490                 495     


Arg Asn Lys Pro His Thr Pro Phe Arg Ala Ser Lys Leu Thr Gln Val 
            500                 505                 510         


Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys Met Ile Ala 
        515                 520                 525             


Thr Ile Ser Pro Gly Met Ala Ser Cys Glu Asn Thr Leu Asn Thr Leu 
    530                 535                 540                 


Arg Tyr Ala Asn Arg Val Lys Glu Phe Gly Ile Ser Pro Ser Asp Ile 
545                 550                 555                 560 


Pro Phe Ser Gln Gly Ser Gly Ser Arg Pro Asp Leu Ser Pro Ser Tyr 
                565                 570                 575     


Glu Tyr Asp Asp Phe Ser Pro Ser Val Thr Arg Val Lys Glu Leu Thr 
            580                 585                 590         


Val Asp Pro Thr Ala Ala Gly Asp Val Arg Pro Ile Met His His Pro 
        595                 600                 605             


Pro Asn Gln Ile Asp Asp Leu Glu Thr Gln Trp Gly Val Gly Ser Ser 
    610                 615                 620                 


Pro Gln Arg Asp Asp Leu Lys Leu Leu Cys Glu Gln Asn Glu Glu Glu 
625                 630                 635                 640 


Val Ser Pro Gln Leu Phe Thr Phe His Glu Ala Val Ser Gln Met Val 
                645                 650                 655     


Glu Met Glu Glu Gln Val Val Glu Asp His Arg Ala Val Phe Gln Glu 
            660                 665                 670         


Ser Ile Arg Trp Leu Glu Asp Glu Lys Ala Leu Leu Glu Met Thr Glu 
        675                 680                 685             


Glu Val Asp Tyr Asp Val Asp Ser Tyr Ala Thr Gln Leu Glu Ala Ile 
    690                 695                 700                 


Leu Glu Gln Lys Ile Asp Ile Leu Thr Glu Leu Arg Asp Lys Val Lys 
705                 710                 715                 720 


Ser Phe Arg Ala Ala Leu Gln Glu Glu Glu Gln Ala Ser Lys Gln Ile 
                725                 730                 735     


Asn Pro Lys Arg Pro Arg Ala Leu 
            740                 


<210> 7163
<211> 566
<212> PRT
<213> Homo sapiens

<400> 7163
Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
            180                 185                 190         


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
        195                 200                 205             


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
    210                 215                 220                 


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
225                 230                 235                 240 


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
                245                 250                 255     


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
            260                 265                 270         


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
        275                 280                 285             


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
    290                 295                 300                 


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
305                 310                 315                 320 


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
                325                 330                 335     


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
            340                 345                 350         


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
        355                 360                 365             


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
    370                 375                 380                 


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
385                 390                 395                 400 


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
                405                 410                 415     


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
            420                 425                 430         


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
        435                 440                 445             


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
    450                 455                 460                 


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
465                 470                 475                 480 


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
                485                 490                 495     


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
            500                 505                 510         


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
        515                 520                 525             


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
    530                 535                 540                 


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
545                 550                 555                 560 


Leu Ile Ser Leu Leu Ser 
                565     


<210> 7164
<211> 265
<212> PRT
<213> Homo sapiens

<400> 7164
Met Cys Thr Ser Glu Thr Phe Gln Ala Leu Asp Thr Phe Glu Ala Arg 
1               5                   10                  15      


His Asp Asp Ile Val Leu Ala Ser Tyr Pro Lys Cys Gly Ser Asn Trp 
            20                  25                  30          


Ile Leu His Ile Val Ser Glu Leu Ile Tyr Ala Val Ser Lys Lys Lys 
        35                  40                  45              


Tyr Lys Tyr Pro Glu Phe Pro Val Leu Glu Cys Gly Asp Ser Glu Lys 
    50                  55                  60                  


Tyr Gln Arg Met Lys Gly Phe Pro Ser Pro Arg Ile Leu Ala Thr His 
65                  70                  75                  80  


Leu His Tyr Asp Lys Leu Pro Gly Ser Ile Phe Glu Asn Lys Ala Lys 
                85                  90                  95      


Ile Leu Val Ile Phe Arg Asn Pro Lys Asp Thr Ala Val Ser Phe Leu 
            100                 105                 110         


His Phe His Asn Asp Val Pro Asp Ile Pro Ser Tyr Gly Ser Trp Asp 
        115                 120                 125             


Glu Phe Phe Arg Gln Phe Met Lys Gly Gln Val Ser Trp Gly Arg Tyr 
    130                 135                 140                 


Phe Asp Phe Ala Ile Asn Trp Asn Lys His Leu Asp Gly Asp Asn Val 
145                 150                 155                 160 


Lys Phe Ile Leu Tyr Glu Asp Leu Lys Glu Asn Leu Ala Ala Gly Ile 
                165                 170                 175     


Lys Gln Ile Ala Glu Phe Leu Gly Phe Phe Leu Thr Gly Glu Gln Ile 
            180                 185                 190         


Gln Thr Ile Ser Val Gln Ser Thr Phe Gln Ala Met Arg Ala Lys Ser 
        195                 200                 205             


Gln Asp Thr His Gly Ala Val Gly Pro Phe Leu Phe Arg Lys Gly Glu 
    210                 215                 220                 


Val Gly Asp Trp Lys Asn Leu Phe Ser Glu Ile Gln Asn Gln Glu Met 
225                 230                 235                 240 


Asp Glu Lys Phe Lys Glu Cys Leu Ala Gly Thr Ser Leu Gly Ala Lys 
                245                 250                 255     


Leu Lys Tyr Glu Ser Tyr Cys Gln Gly 
            260                 265 


<210> 7165
<211> 935
<212> PRT
<213> Homo sapiens

<400> 7165
Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys 
1               5                   10                  15      


Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Glu Gln Ser Tyr 
            20                  25                  30          


Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Ala Tyr 
        35                  40                  45              


Ser Gly Thr Pro Leu Thr Glu Glu Lys Glu Lys Ile Val Trp Val Arg 
    50                  55                  60                  


Phe Glu Asn Ala Asp Leu Asn Asp Thr Ser Arg Asn Leu Glu Phe His 
65                  70                  75                  80  


Glu Ile His Ser Thr Gly Asn Glu Pro Pro Leu Leu Ile Met Ile Gly 
                85                  90                  95      


Tyr Ser Asp Gly Met Gln Val Trp Ser Ile Pro Ile Ser Gly Glu Ala 
            100                 105                 110         


Gln Glu Leu Phe Ser Val Arg His Gly Pro Ile Arg Ala Ala Arg Ile 
        115                 120                 125             


Leu Pro Ala Pro Gln Phe Gly Ala Gln Lys Cys Asp Asn Phe Ala Glu 
    130                 135                 140                 


Lys Arg Pro Leu Leu Gly Val Cys Lys Ser Ile Gly Ser Ser Gly Thr 
145                 150                 155                 160 


Ser Pro Pro Tyr Cys Cys Val Asp Leu Tyr Ser Leu Arg Thr Gly Glu 
                165                 170                 175     


Met Val Lys Ser Ile Gln Phe Lys Thr Pro Ile Tyr Asp Leu His Cys 
            180                 185                 190         


Asn Lys Arg Ile Leu Val Val Val Leu Gln Glu Lys Ile Ala Ala Phe 
        195                 200                 205             


Asp Ser Cys Thr Phe Thr Lys Lys Phe Phe Val Thr Ser Cys Tyr Pro 
    210                 215                 220                 


Cys Pro Gly Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu 
225                 230                 235                 240 


Ala Tyr Ala Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly 
                245                 250                 255     


Ala Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala 
            260                 265                 270         


Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr 
        275                 280                 285             


Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala 
    290                 295                 300                 


Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr 
305                 310                 315                 320 


Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu 
                325                 330                 335     


Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys 
            340                 345                 350         


Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr 
        355                 360                 365             


Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His 
    370                 375                 380                 


Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His 
385                 390                 395                 400 


Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp 
                405                 410                 415     


Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe 
            420                 425                 430         


Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser 
        435                 440                 445             


Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu 
    450                 455                 460                 


Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser 
465                 470                 475                 480 


Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly 
                485                 490                 495     


Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro 
            500                 505                 510         


Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro 
        515                 520                 525             


Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg 
    530                 535                 540                 


Thr Gly Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met 
545                 550                 555                 560 


Gly Gly Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp 
                565                 570                 575     


Phe Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln 
            580                 585                 590         


Val Val Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val 
        595                 600                 605             


Glu His Met Met Glu Pro Arg Pro Leu Ser Thr Ala Pro Lys Ile Ser 
    610                 615                 620                 


Asp Asp Thr Pro Leu Glu Met Met Thr Ser Pro Arg Ala Ser Trp Thr 
625                 630                 635                 640 


Leu Val Arg Thr Pro Gln Trp Asn Glu Leu Gln Pro Pro Phe Asn Ala 
                645                 650                 655     


Asn His Pro Leu Leu Leu Ala Ala Asp Ala Val Gln Tyr Tyr Gln Phe 
            660                 665                 670         


Leu Leu Ala Gly Leu Val Pro Pro Gly Ser Pro Gly Pro Ile Thr Arg 
        675                 680                 685             


His Gly Ser Tyr Asp Ser Leu Ala Ser Asp His Ser Gly Gln Glu Asp 
    690                 695                 700                 


Glu Glu Trp Leu Ser Gln Val Glu Ile Val Thr His Thr Gly Pro His 
705                 710                 715                 720 


Arg Arg Leu Trp Met Gly Pro Gln Phe Gln Phe Lys Thr Ile His Pro 
                725                 730                 735     


Ser Gly Gln Thr Thr Val Ile Ser Ser Ser Ser Ser Val Leu Gln Ser 
            740                 745                 750         


His Gly Pro Ser Asp Thr Pro Gln Pro Leu Leu Asp Phe Asp Thr Asp 
        755                 760                 765             


Asp Leu Asp Leu Asn Ser Leu Arg Ile Gln Pro Val Arg Ser Asp Pro 
    770                 775                 780                 


Val Ser Met Pro Gly Ser Ser Arg Pro Val Ser Asp Arg Arg Gly Val 
785                 790                 795                 800 


Ser Thr Val Ile Asp Ala Ala Ser Gly Thr Phe Asp Arg Ser Val Thr 
                805                 810                 815     


Leu Leu Glu Val Cys Gly Ser Trp Pro Glu Gly Phe Gly Leu Arg His 
            820                 825                 830         


Met Ser Ser Met Glu His Thr Glu Glu Gly Leu Arg Glu Arg Leu Ala 
        835                 840                 845             


Asp Ala Met Ala Glu Ser Pro Ser Arg Asp Val Val Gly Ser Gly Thr 
    850                 855                 860                 


Asp Thr Ala Leu Asp Val Ala Val Lys Thr Phe Pro Pro Glu Arg His 
865                 870                 875                 880 


Val Ala Val Lys Cys Phe Glu Leu Gln Arg Glu Gly Ser Ile Glu Thr 
                885                 890                 895     


Leu Ser Asn Ser Ser Gly Ser Thr Ser Gly Ser Ile Pro Arg Asn Phe 
            900                 905                 910         


Asp Gly Tyr Arg Ser Pro Leu Pro Thr Asn Glu Ser Gln Pro Leu Ser 
        915                 920                 925             


Leu Phe Pro Thr Gly Phe Pro 
    930                 935 


<210> 7166
<211> 204
<212> PRT
<213> Homo sapiens

<400> 7166
Met Glu Ala Ala Gly Ser Pro Ala Ala Thr Glu Thr Gly Lys Tyr Ile 
1               5                   10                  15      


Ala Ser Thr Gln Arg Pro Asp Gly Thr Trp Arg Lys Gln Arg Arg Val 
            20                  25                  30          


Lys Glu Gly Tyr Val Pro Gln Glu Glu Val Pro Val Tyr Glu Asn Lys 
        35                  40                  45              


Tyr Val Lys Phe Phe Lys Ser Lys Pro Glu Leu Pro Pro Gly Leu Ser 
    50                  55                  60                  


Pro Glu Ala Thr Ala Pro Val Thr Pro Ser Arg Pro Glu Gly Gly Glu 
65                  70                  75                  80  


Pro Gly Leu Ser Lys Thr Ala Lys Arg Asn Leu Lys Arg Lys Glu Lys 
                85                  90                  95      


Arg Arg Gln Gln Gln Glu Lys Gly Glu Ala Glu Ala Leu Ser Arg Thr 
            100                 105                 110         


Leu Asp Lys Val Ser Leu Glu Glu Thr Ala Gln Leu Pro Ser Ala Pro 
        115                 120                 125             


Gln Gly Ser Arg Ala Ala Pro Thr Ala Ala Ser Asp Gln Pro Asp Ser 
    130                 135                 140                 


Ala Ala Thr Thr Glu Lys Ala Lys Lys Ile Lys Asn Leu Lys Lys Lys 
145                 150                 155                 160 


Leu Arg Gln Val Glu Glu Leu Gln Gln Arg Ile Gln Ala Gly Glu Val 
                165                 170                 175     


Ser Gln Pro Ser Lys Glu Gln Leu Glu Lys Leu Ala Arg Arg Arg Ala 
            180                 185                 190         


Leu Glu Glu Glu Leu Glu Asp Leu Glu Leu Gly Leu 
        195                 200                 


<210> 7167
<211> 220
<212> PRT
<213> Homo sapiens

<400> 7167
Met Ser Ser Gly Asn Tyr Gln Gln Ser Glu Ala Leu Ser Lys Pro Thr 
1               5                   10                  15      


Phe Ser Glu Glu Gln Ala Ser Ala Leu Val Glu Ser Val Phe Gly Leu 
            20                  25                  30          


Lys Val Ser Lys Val Arg Pro Leu Pro Ser Tyr Asp Asp Gln Asn Phe 
        35                  40                  45              


His Val Tyr Val Ser Lys Thr Lys Asp Gly Pro Thr Glu Tyr Val Leu 
    50                  55                  60                  


Lys Ile Ser Asn Thr Lys Ala Ser Lys Asn Pro Asp Leu Ile Glu Val 
65                  70                  75                  80  


Gln Asn His Ile Ile Met Phe Leu Lys Ala Ala Gly Phe Pro Thr Ala 
                85                  90                  95      


Ser Val Cys His Thr Lys Gly Asp Asn Thr Ala Ser Leu Val Ser Val 
            100                 105                 110         


Asp Ser Gly Ser Glu Ile Lys Ser Tyr Leu Val Arg Leu Leu Thr Tyr 
        115                 120                 125             


Leu Pro Gly Arg Pro Ile Ala Glu Leu Pro Val Ser Pro Gln Leu Leu 
    130                 135                 140                 


Tyr Glu Ile Gly Lys Leu Ala Ala Lys Leu Asp Lys Thr Leu Gln Arg 
145                 150                 155                 160 


Phe His His Pro Lys Leu Ser Ser Leu His Arg Glu Asn Phe Ile Trp 
                165                 170                 175     


Asn Leu Lys Asn Val Pro Leu Leu Glu Lys Tyr Leu Tyr Ala Leu Gly 
            180                 185                 190         


Gln Asn Arg Asn Arg Glu Ile Val Glu His Val Ile His Leu Phe Lys 
        195                 200                 205             


Glu Glu Val Met Thr Lys Leu Ser His Phe Arg Glu 
    210                 215                 220 


<210> 7168
<211> 200
<212> PRT
<213> Homo sapiens

<400> 7168
Met Ser Ser Asp Ser Met Asp Gln Pro Arg Asn Pro Cys Glu Asn Glu 
1               5                   10                  15      


Pro Leu Thr Pro Gly Tyr His Gly Phe Pro Ala Arg Asp Ser Gln Gly 
            20                  25                  30          


Asn Gln Glu Pro Thr Thr Thr Pro Asp Ala Met Val Gln Pro Phe Thr 
        35                  40                  45              


Thr Ile Pro Phe Pro Pro Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr 
    50                  55                  60                  


Gly Val Pro His Thr Gln Asp Tyr Ala Gly Gln Thr Gly Glu His Asn 
65                  70                  75                  80  


Leu Thr Leu Tyr Gly Ser Thr Gln Ala His Gly Glu Gln Ser Ser Asn 
                85                  90                  95      


Ser Pro Ser Thr Gln Asn Gly Ser Leu Thr Gln Thr Glu Gly Gly Ala 
            100                 105                 110         


Gln Thr Asp Gly Gln Gln Ser Gln Thr Gln Ser Ser Glu Asn Ser Glu 
        115                 120                 125             


Ser Lys Ser Thr Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg 
    130                 135                 140                 


Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile 
145                 150                 155                 160 


Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly 
                165                 170                 175     


Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys 
            180                 185                 190         


Leu His Gly Thr Val Val Glu Gly 
        195                 200 


<210> 7169
<211> 128
<212> PRT
<213> Homo sapiens

<400> 7169
Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Ile Ser Val Leu Asn Ser Val Thr Val Ala Lys Ser Pro 
        115                 120                 125             


<210> 7170
<211> 130
<212> PRT
<213> Homo sapiens

<400> 7170
Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Ser Leu Gln Asn Asp Asp Leu Phe Lys Thr Asp Cys His 
        115                 120                 125             


His Gln 
    130 


<210> 7171
<211> 507
<212> PRT
<213> Homo sapiens

<400> 7171
Met Trp Leu Thr Ser Tyr Pro Ser Pro Asn Phe Pro Val Ser Val Leu 
1               5                   10                  15      


Gln Asn Gly Val Lys Met Thr Asn Glu Ala Pro Lys Gly Leu Arg Ala 
            20                  25                  30          


Asn Ile Ile Arg Ser Tyr Leu Met Asp Pro Ile Ser Asp Pro Glu Phe 
        35                  40                  45              


Phe Gly Ser Cys Lys Lys Pro Glu Glu Phe Lys Lys Leu Leu Tyr Gly 
    50                  55                  60                  


Leu Cys Phe Phe His Ala Leu Val Gln Glu Arg Arg Lys Phe Gly Pro 
65                  70                  75                  80  


Leu Gly Trp Asn Ile Pro Tyr Glu Phe Asn Glu Thr Asp Leu Arg Ile 
                85                  90                  95      


Ser Val Gln Gln Leu His Met Phe Leu Asn Gln Tyr Glu Glu Leu Pro 
            100                 105                 110         


Tyr Glu Ala Leu Arg Tyr Met Thr Gly Glu Cys Asn Tyr Gly Gly Arg 
        115                 120                 125             


Val Thr Asp Asp Trp Asp Arg Arg Thr Leu Arg Ser Ile Leu Asn Lys 
    130                 135                 140                 


Phe Phe Asn Pro Glu Leu Val Glu Asn Ser Asp Tyr Lys Phe Asp Ser 
145                 150                 155                 160 


Ser Gly Ile Tyr Phe Val Pro Pro Ser Gly Asp His Lys Ser Tyr Ile 
                165                 170                 175     


Glu Tyr Thr Lys Thr Leu Pro Leu Thr Pro Ala Pro Glu Ile Phe Gly 
            180                 185                 190         


Met Asn Ala Asn Ala Asp Ile Thr Lys Asp Gln Ser Glu Thr Gln Leu 
        195                 200                 205             


Leu Phe Asp Asn Ile Leu Leu Thr Gln Ser Arg Ser Ala Gly Ala Gly 
    210                 215                 220                 


Ala Lys Ser Ser Asp Glu Val Val Asn Glu Val Ala Ser Asp Ile Leu 
225                 230                 235                 240 


Gly Lys Leu Pro Asn Asn Phe Asp Ile Glu Ala Ala Met Arg Arg Tyr 
                245                 250                 255     


Pro Thr Thr Tyr Thr Gln Ser Met Asn Thr Val Leu Val Gln Glu Met 
            260                 265                 270         


Gly Arg Phe Asn Lys Leu Leu Lys Thr Ile Arg Asp Ser Cys Val Asn 
        275                 280                 285             


Ile Gln Lys Ala Ile Lys Gly Leu Ala Val Met Ser Thr Asp Leu Glu 
    290                 295                 300                 


Glu Val Val Ser Ser Ile Leu Asn Val Lys Ile Pro Glu Met Trp Met 
305                 310                 315                 320 


Gly Lys Ser Tyr Pro Ser Leu Lys Pro Leu Gly Ser Tyr Val Asn Asp 
                325                 330                 335     


Phe Leu Ala Arg Leu Lys Phe Leu Gln Gln Trp Tyr Glu Val Gly Pro 
            340                 345                 350         


Pro Pro Val Phe Trp Leu Ser Gly Phe Phe Phe Thr Gln Ala Phe Leu 
        355                 360                 365             


Thr Gly Ala Gln Gln Asn Tyr Ala Arg Lys Tyr Thr Ile Pro Ile Asp 
    370                 375                 380                 


Leu Leu Gly Phe Asp Tyr Glu Val Met Glu Asp Lys Glu Tyr Lys His 
385                 390                 395                 400 


Pro Pro Glu Asp Gly Val Phe Ile His Gly Leu Phe Leu Asp Gly Ala 
                405                 410                 415     


Ser Trp Asn Arg Lys Ile Lys Lys Leu Ala Glu Ser His Pro Lys Ile 
            420                 425                 430         


Leu Tyr Asp Thr Val Pro Val Met Trp Leu Lys Pro Cys Lys Arg Ala 
        435                 440                 445             


Asp Ile Pro Lys Arg Pro Ser Tyr Val Ala Pro Leu Tyr Lys Thr Ser 
    450                 455                 460                 


Glu Arg Arg Gly Val Leu Ser Thr Thr Gly His Ser Thr Asn Phe Val 
465                 470                 475                 480 


Ile Ala Met Thr Leu Pro Ser Asp Gln Pro Lys Glu His Trp Ile Gly 
                485                 490                 495     


Arg Gly Val Ala Leu Leu Cys Gln Leu Asn Ser 
            500                 505         


<210> 7172
<211> 560
<212> PRT
<213> Homo sapiens

<400> 7172
Met Ala Ala Ser Ala Lys Arg Lys Gln Glu Glu Lys His Leu Lys Met 
1               5                   10                  15      


Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp Cys 
            20                  25                  30          


Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe Val 
        35                  40                  45              


Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His Arg 
    50                  55                  60                  


Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu Phe 
65                  70                  75                  80  


Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly Leu 
                85                  90                  95      


Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln Lys 
            100                 105                 110         


Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr Val 
        115                 120                 125             


Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile Ser 
    130                 135                 140                 


Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro Leu 
145                 150                 155                 160 


Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys Gly 
                165                 170                 175     


Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln Gln 
            180                 185                 190         


Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile Phe 
        195                 200                 205             


Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn Phe 
    210                 215                 220                 


Ala His Phe Asn Ser His Ala Ala Gln Asn Ser Ala Asn Ala Asp Phe 
225                 230                 235                 240 


Ala Asn Phe Asp Ala Phe Gly Gln Ser Ser Gly Ser Ser Asn Phe Gly 
                245                 250                 255     


Gly Phe Pro Thr Ala Ser His Ser Pro Phe Gln Pro Gln Thr Thr Gly 
            260                 265                 270         


Gly Ser Ala Ala Ser Val Asn Ala Asn Phe Ala His Phe Asp Asn Phe 
        275                 280                 285             


Pro Lys Ser Ser Ser Ala Asp Phe Gly Thr Phe Asn Thr Ser Gln Ser 
    290                 295                 300                 


His Gln Thr Ala Ser Ala Val Ser Lys Val Ser Thr Asn Lys Ala Gly 
305                 310                 315                 320 


Leu Gln Thr Ala Asp Lys Tyr Ala Ala Leu Ala Asn Leu Asp Asn Ile 
                325                 330                 335     


Phe Ser Ala Gly Gln Gly Gly Asp Gln Gly Ser Gly Phe Gly Thr Thr 
            340                 345                 350         


Gly Lys Ala Pro Val Gly Ser Val Val Ser Val Pro Ser Gln Ser Ser 
        355                 360                 365             


Ala Ser Ser Asp Lys Tyr Ala Ala Leu Ala Glu Leu Asp Ser Val Phe 
    370                 375                 380                 


Ser Ser Ala Ala Thr Ser Ser Asn Ala Tyr Thr Ser Thr Ser Asn Ala 
385                 390                 395                 400 


Ser Ser Asn Val Phe Gly Thr Val Pro Val Val Ala Ser Ala Gln Thr 
                405                 410                 415     


Gln Pro Ala Ser Ser Ser Val Pro Ala Pro Phe Gly Ala Thr Pro Ser 
            420                 425                 430         


Thr Asn Pro Phe Val Ala Ala Ala Gly Pro Ser Val Ala Ser Ser Thr 
        435                 440                 445             


Asn Pro Phe Gln Thr Asn Ala Arg Gly Ala Thr Ala Ala Thr Phe Gly 
    450                 455                 460                 


Thr Ala Ser Met Ser Met Pro Thr Gly Phe Gly Thr Pro Ala Pro Tyr 
465                 470                 475                 480 


Ser Leu Pro Thr Ser Phe Ser Gly Ser Phe Gln Gln Pro Ala Phe Pro 
                485                 490                 495     


Ala Gln Ala Ala Phe Pro Gln Gln Thr Ala Phe Ser Gln Gln Pro Asn 
            500                 505                 510         


Gly Phe Ala Ala Phe Gly Gln Thr Lys Pro Val Val Thr Pro Phe Gly 
        515                 520                 525             


Gln Val Ala Ala Ala Gly Val Ser Ser Asn Pro Phe Met Thr Gly Ala 
    530                 535                 540                 


Pro Thr Gly Gln Phe Pro Thr Gly Ser Ser Ser Thr Asn Pro Phe Leu 
545                 550                 555                 560 


<210> 7173
<211> 800
<212> PRT
<213> Homo sapiens

<400> 7173
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile 
                325                 330                 335     


Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val 
            340                 345                 350         


Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe 
        355                 360                 365             


Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu 
    370                 375                 380                 


Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe 
385                 390                 395                 400 


Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His 
                405                 410                 415     


Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu 
            420                 425                 430         


Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro 
        435                 440                 445             


Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp 
    450                 455                 460                 


Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr 
465                 470                 475                 480 


Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val 
                485                 490                 495     


Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys 
            500                 505                 510         


Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His 
        515                 520                 525             


Val His Ser Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys 
    530                 535                 540                 


Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn 
545                 550                 555                 560 


Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr 
                565                 570                 575     


Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln 
            580                 585                 590         


Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln 
        595                 600                 605             


Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr 
    610                 615                 620                 


Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln 
625                 630                 635                 640 


Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp 
                645                 650                 655     


Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg 
            660                 665                 670         


Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu 
        675                 680                 685             


Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr 
    690                 695                 700                 


Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser 
705                 710                 715                 720 


Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp 
                725                 730                 735     


Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr 
            740                 745                 750         


Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp 
        755                 760                 765             


Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys 
    770                 775                 780                 


Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
785                 790                 795                 800 


<210> 7174
<211> 47
<212> PRT
<213> Homo sapiens

<400> 7174
Met Asp Asp Gln Gln Ala Leu Asn Ser Ile Met Gln Asp Leu Ala Val 
1               5                   10                  15      


Leu His Lys Ala Ser Arg Pro Ala Leu Ser Leu Gln Glu Thr Arg Lys 
            20                  25                  30          


Ala Lys Ser Ser Ser Pro Lys Lys Gln Asn Asp Val Arg Val Lys 
        35                  40                  45          


<210> 7175
<211> 423
<212> PRT
<213> Homo sapiens

<400> 7175
Met Val Ser Phe Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser 
1               5                   10                  15      


Gly Gln Arg Phe Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp 
            20                  25                  30          


Pro Thr Gln Phe Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly 
        35                  40                  45              


Thr Asp Leu Glu Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys 
    50                  55                  60                  


Leu Asp Tyr Arg Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala 
65                  70                  75                  80  


Gly Gly Met Leu Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg 
                85                  90                  95      


Thr Asp Val Cys Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln 
            100                 105                 110         


Ala Phe Ala Gln Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu 
        115                 120                 125             


Glu Lys Gly Phe Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys 
    130                 135                 140                 


Gly Phe Ser Glu Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val 
145                 150                 155                 160 


Leu Leu Ala Asn Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr 
                165                 170                 175     


Asn Glu Asn Leu Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys 
            180                 185                 190         


Leu Phe Lys Ser Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala 
        195                 200                 205             


Ser Leu Arg Lys Val Ser Met Asp Asn Arg Leu Met Glu Leu Phe Pro 
    210                 215                 220                 


Ala Asn Lys Gln Ser Val Glu His Phe Thr Lys Tyr Phe Thr Glu Ala 
225                 230                 235                 240 


Gly Leu Lys Glu Leu Ser Glu Tyr Val Arg Asn Gln Gln Thr Ile Gly 
                245                 250                 255     


Ala Arg Lys Glu Leu Gln Lys Glu Leu Gln Glu Gln Met Ser Arg Gly 
            260                 265                 270         


Asp Pro Phe Lys Asp Ile Ile Leu Tyr Val Lys Glu Glu Met Lys Lys 
        275                 280                 285             


Asn Asn Ile Pro Glu Pro Val Val Ile Gly Ile Val Trp Ser Ser Val 
    290                 295                 300                 


Met Ser Thr Val Glu Trp Asn Lys Lys Glu Glu Leu Val Ala Glu Gln 
305                 310                 315                 320 


Ala Ile Lys His Leu Lys Gln Tyr Ser Pro Leu Leu Ala Ala Phe Thr 
                325                 330                 335     


Thr Gln Gly Gln Ser Glu Leu Thr Leu Leu Leu Lys Ile Gln Glu Tyr 
            340                 345                 350         


Cys Tyr Asp Asn Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val 
        355                 360                 365             


Leu Phe Tyr Lys Ala Glu Val Leu Ser Glu Glu Pro Ile Leu Lys Trp 
    370                 375                 380                 


Tyr Lys Asp Ala His Val Ala Lys Gly Lys Ser Val Phe Leu Glu Gln 
385                 390                 395                 400 


Met Lys Lys Phe Val Glu Trp Leu Lys Asn Ala Glu Glu Glu Ser Glu 
                405                 410                 415     


Ser Glu Ala Glu Glu Gly Asp 
            420             


<210> 7176
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7176
Met Ser Arg Arg Arg Phe Asp Cys Arg Ser Ile Ser Gly Leu Leu Thr 
1               5                   10                  15      


Thr Thr Pro Gln Ile Pro Ile Lys Met Glu Asn Phe Asn Asn Phe Tyr 
            20                  25                  30          


Ile Leu Thr Ser Lys Glu Leu Gly Arg Gly Lys Phe Ala Val Val Arg 
        35                  40                  45              


Gln Cys Ile Ser Lys Ser Thr Gly Gln Glu Tyr Ala Ala Lys Phe Leu 
    50                  55                  60                  


Lys Lys Arg Arg Arg Gly Gln Asp Cys Arg Ala Glu Ile Leu His Glu 
65                  70                  75                  80  


Ile Ala Val Leu Glu Leu Ala Lys Ser Cys Pro Arg Val Ile Asn Leu 
                85                  90                  95      


His Glu Val Tyr Glu Asn Thr Ser Glu Ile Ile Leu Ile Leu Glu Tyr 
            100                 105                 110         


Ala Ala Gly Gly Glu Ile Phe Ser Leu Cys Leu Pro Glu Leu Ala Glu 
        115                 120                 125             


Met Val Ser Glu Asn Asp Val Ile Arg Leu Ile Lys Gln Ile Leu Glu 
    130                 135                 140                 


Gly Val Tyr Tyr Leu His Gln Asn Asn Ile Val His Leu Asp Leu Lys 
145                 150                 155                 160 


Pro Gln Asn Ile Leu Leu Ser Ser Ile Tyr Pro Leu Gly Asp Ile Lys 
                165                 170                 175     


Ile Val Asp Phe Gly Met Ser Arg Lys Ile Gly His Ala Cys Glu Leu 
            180                 185                 190         


Arg Glu Ile Met Gly Thr Pro Glu Tyr Leu Ala Pro Glu Ile Leu Asn 
        195                 200                 205             


Tyr Asp Pro Ile Thr Thr Ala Thr Asp Met Trp Asn Ile Gly Ile Ile 
    210                 215                 220                 


Ala Tyr Met Leu Leu Thr His Thr Ser Pro Phe Val Gly Glu Asp Asn 
225                 230                 235                 240 


Gln Glu Thr Tyr Leu Asn Ile Ser Gln Val Asn Val Asp Tyr Ser Glu 
                245                 250                 255     


Glu Thr Phe Ser Ser Val Ser Gln Leu Ala Thr Asp Phe Ile Gln Ser 
            260                 265                 270         


Leu Leu Val Lys Asn Pro Glu Lys Arg Pro Thr Ala Glu Ile Cys Leu 
        275                 280                 285             


Ser His Ser Trp Leu Gln Gln Trp Asp Phe Glu Asn Leu Phe His Pro 
    290                 295                 300                 


Glu Glu Thr Ser Ser Ser Ser Gln Thr Gln Asp His Ser Val Arg Ser 
305                 310                 315                 320 


Ser Glu Asp Lys Thr Ser Lys Ser Ser Cys Asn Gly Thr Cys Gly Asp 
                325                 330                 335     


Arg Glu Asp Lys Glu Asn Ile Pro Glu Asp Ser Ser Met Val Ser Lys 
            340                 345                 350         


Arg Phe Arg Phe Asp Asp Ser Leu Pro Asn Pro His Glu Leu Val Ser 
        355                 360                 365             


Asp Leu Leu Cys 
    370         


<210> 7177
<211> 303
<212> PRT
<213> Homo sapiens

<400> 7177
Met Met Asp Val Ser Gly Val Gly Phe Pro Ser Lys Val Pro Trp Lys 
1               5                   10                  15      


Lys Met Ser Ala Glu Glu Leu Glu Asn Gln Tyr Cys Pro Ser Arg Trp 
            20                  25                  30          


Val Val Arg Leu Gly Ala Glu Glu Ala Leu Arg Thr Tyr Ser Gln Ile 
        35                  40                  45              


Gly Ile Glu Ala Thr Thr Arg Ala Arg Ala Thr Arg Lys Ser Leu Leu 
    50                  55                  60                  


His Val Pro Tyr Gly Asp Gly Glu Gly Glu Lys Val Asp Ile Tyr Phe 
65                  70                  75                  80  


Pro Asp Glu Ser Ser Glu Ala Leu Pro Phe Phe Leu Phe Phe His Gly 
                85                  90                  95      


Gly Tyr Trp Gln Ser Gly Ser Lys Asp Glu Ser Ala Phe Met Val His 
            100                 105                 110         


Pro Leu Thr Ala Gln Gly Val Ala Val Val Ile Val Ala Tyr Gly Ile 
        115                 120                 125             


Ala Pro Lys Gly Thr Leu Asp His Met Val Asp Gln Val Thr Arg Ser 
    130                 135                 140                 


Val Ala Phe Val Gln Lys Arg Tyr Pro Ser Asn Lys Gly Ile Tyr Leu 
145                 150                 155                 160 


Cys Gly His Ser Ala Gly Ala His Leu Ala Ala Met Met Leu Leu Ala 
                165                 170                 175     


Asp Trp Thr Lys His Gly Val Thr Pro Asn Leu Arg Gly Phe Phe Leu 
            180                 185                 190         


Val Ser Gly Val Phe Asp Leu Glu Pro Ile Val Tyr Thr Ser Gln Asn 
        195                 200                 205             


Val Ala Leu Gln Leu Thr Leu Glu Asp Ala Gln Arg Asn Ser Pro Gln 
    210                 215                 220                 


Leu Lys Val Ala Gln Ala Gln Pro Val Asp Pro Thr Cys Arg Val Leu 
225                 230                 235                 240 


Val Val Val Gly Gln Phe Asp Ser Pro Glu Phe His Arg Gln Ser Trp 
                245                 250                 255     


Glu Phe Tyr Gln Thr Leu Cys Gln Gly Glu Trp Lys Ala Ser Phe Glu 
            260                 265                 270         


Glu Leu His Asp Val Asp His Phe Glu Ile Val Glu Asn Leu Thr Gln 
        275                 280                 285             


Lys Asp Asn Val Leu Thr Gln Ile Ile Leu Lys Thr Ile Phe Gln 
    290                 295                 300             


<210> 7178
<211> 227
<212> PRT
<213> Homo sapiens

<400> 7178
Met Ala Leu His Asp Met Glu Asp Phe Thr Phe Asp Gly Thr Lys Arg 
1               5                   10                  15      


Leu Ser Val Asn Tyr Val Lys Gly Ile Leu Gln Pro Thr Asp Thr Cys 
            20                  25                  30          


Asp Ile Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu 
        35                  40                  45              


Leu Ile Ser Thr Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln Glu Ile 
    50                  55                  60                  


Val Glu Leu Ile Gln Asn Glu Gly Asp Val Glu Lys Ser Lys Arg Ala 
65                  70                  75                  80  


Pro Thr His Gln Arg Phe Pro Phe Leu Glu Met Lys Ile Pro Ser Leu 
                85                  90                  95      


Gly Ser Val Cys Trp Gly Ser Trp His Glu His Val Lys Gly Trp Trp 
            100                 105                 110         


Glu Ala Lys Asp Lys His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Met 
        115                 120                 125             


Lys Lys Asn Pro Lys His Glu Ile Gln Lys Leu Ala Glu Phe Ile Gly 
    130                 135                 140                 


Lys Lys Leu Asp Asp Lys Val Leu Asp Lys Ile Val His Tyr Thr Ser 
145                 150                 155                 160 


Phe Asp Val Met Lys Gln Asn Pro Met Ala Asn Tyr Ser Ser Ile Pro 
                165                 170                 175     


Ala Glu Ile Met Asp His Ser Ile Ser Pro Phe Met Arg Lys Gly Ala 
            180                 185                 190         


Val Gly Asp Trp Lys Lys His Phe Thr Val Ala Gln Asn Glu Arg Phe 
        195                 200                 205             


Asp Glu Asp Tyr Lys Lys Lys Met Thr Asp Thr Arg Leu Thr Phe His 
    210                 215                 220                 


Phe Gln Phe 
225         


<210> 7179
<211> 121
<212> PRT
<213> Homo sapiens

<400> 7179
Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Ser Lys Phe Ser Ile Pro 
        115                 120     


<210> 7180
<211> 88
<212> PRT
<213> Homo sapiens

<400> 7180
Leu Ser Phe Arg Ala Asp Ser Ala His Ala Ser Met Val Asn Val Pro 
1               5                   10                  15      


Lys Thr Arg Arg Thr Phe Cys Lys Lys Cys Gly Lys His Gln Pro His 
            20                  25                  30          


Lys Val Thr Gln Tyr Lys Lys Gly Lys Asp Ser Leu Tyr Ala Gln Gly 
        35                  40                  45              


Lys Arg Arg Tyr Asp Arg Lys Gln Ser Gly Tyr Gly Gly Gln Thr Lys 
    50                  55                  60                  


Pro Ile Phe Arg Lys Lys Leu His Gln Asn Cys Ile Glu Pro Asn Leu 
65                  70                  75                  80  


Pro Pro Arg Ala Gln Gln Ser Pro 
                85              


<210> 7181
<211> 193
<212> PRT
<213> Homo sapiens

<400> 7181
Met Asp Ser Thr Leu Ala Val Gln Gln Tyr Ile Gln Gln Asn Ile Arg 
1               5                   10                  15      


Ala Asp Cys Ser Asn Ile Asp Lys Ile Leu Glu Pro Pro Glu Gly Gln 
            20                  25                  30          


Asp Glu Gly Val Trp Lys Tyr Glu His Leu Arg Gln Phe Cys Leu Glu 
        35                  40                  45              


Leu Asn Gly Leu Ala Val Lys Leu Gln Ser Glu Cys His Pro Asp Thr 
    50                  55                  60                  


Cys Thr Gln Met Thr Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala 
65                  70                  75                  80  


His Lys Thr Pro Lys Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr 
                85                  90                  95      


Leu Asp Gly Ala Ala Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser 
            100                 105                 110         


Arg Val Ser Ile Lys Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys 
        115                 120                 125             


Arg Arg Ile Tyr Arg Ile Phe Ser His Ala Tyr Phe His His Arg Gln 
    130                 135                 140                 


Ile Phe Asp Glu Tyr Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr 
145                 150                 155                 160 


Lys Phe Val Met Lys Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val 
                165                 170                 175     


Pro Ile Leu Glu Glu Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu 
            180                 185                 190         


Ala 
    


<210> 7182
<211> 1378
<212> PRT
<213> Homo sapiens

<400> 7182
Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210> 7183
<211> 405
<212> PRT
<213> Homo sapiens

<400> 7183
Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Leu 
            340                 345                 350         


Pro Phe Phe Val Leu Ala Leu Thr Ala Ser Thr Tyr Leu Arg Pro Ala 
        355                 360                 365             


Gly Ala Arg Ala Arg Gln Ser Ser Pro Trp Pro Gly Pro Arg Gly Gly 
    370                 375                 380                 


Gln Thr Ser Pro His Cys Ala Glu Gly Pro Gln Ser Ala Gln Leu Ser 
385                 390                 395                 400 


Gly Ala Met Met Asn 
                405 


<210> 7184
<211> 414
<212> PRT
<213> Homo sapiens

<400> 7184
Met Ala Ala Ala Pro Pro Ser Tyr Cys Phe Val Ala Phe Pro Pro Arg 
1               5                   10                  15      


Ala Lys Asp Gly Leu Val Val Phe Gly Lys Asn Ser Ala Arg Pro Arg 
            20                  25                  30          


Asp Glu Val Gln Glu Val Val Tyr Phe Ser Ala Ala Asp His Glu Pro 
        35                  40                  45              


Glu Ser Lys Val Glu Cys Thr Tyr Ile Ser Ile Asp Gln Val Pro Arg 
    50                  55                  60                  


Thr Tyr Ala Ile Met Ile Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Ala Asn Glu Ala Ile Asn 
                85                  90                  95      


Thr Arg Glu Pro Ala Ala Glu Ile Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Gly Glu Thr Ala Lys Glu Ala Leu Asp 
        115                 120                 125             


Val Ile Val Ser Leu Leu Glu Glu His Gly Gln Gly Gly Asn Tyr Phe 
    130                 135                 140                 


Glu Asp Ala Asn Ser Cys His Ser Phe Gln Ser Ala Tyr Leu Ile Val 
145                 150                 155                 160 


Asp Arg Asp Glu Ala Trp Val Leu Glu Thr Ile Gly Lys Tyr Trp Ala 
                165                 170                 175     


Ala Glu Lys Val Thr Glu Gly Val Arg Cys Ile Cys Ser Gln Leu Ser 
            180                 185                 190         


Leu Thr Thr Lys Met Asp Ala Glu His Pro Glu Leu Arg Ser Tyr Ala 
        195                 200                 205             


Gln Ser Gln Gly Trp Trp Thr Gly Glu Gly Glu Phe Asn Phe Ser Glu 
    210                 215                 220                 


Val Phe Ser Pro Val Glu Asp His Leu Asp Cys Gly Ala Gly Lys Asp 
225                 230                 235                 240 


Ser Leu Glu Lys Gln Glu Glu Ser Ile Thr Val Gln Thr Met Met Asn 
                245                 250                 255     


Thr Leu Arg Asp Lys Ala Ser Gly Val Cys Ile Asp Ser Glu Phe Phe 
            260                 265                 270         


Leu Thr Thr Ala Ser Gly Val Ser Val Leu Pro Gln Asn Arg Ser Ser 
        275                 280                 285             


Pro Cys Ile His Tyr Phe Thr Gly Thr Pro Asp Pro Ser Arg Ser Ile 
    290                 295                 300                 


Phe Lys Pro Phe Ile Phe Val Asp Asp Val Lys Leu Val Pro Lys Thr 
305                 310                 315                 320 


Gln Ser Pro Cys Phe Gly Asp Asp Asp Pro Ala Lys Lys Glu Pro Arg 
                325                 330                 335     


Phe Gln Glu Lys Pro Asp Arg Arg His Glu Leu Tyr Lys Ala His Glu 
            340                 345                 350         


Trp Ala Arg Ala Ile Ile Glu Ser Asp Gln Glu Gln Gly Arg Lys Leu 
        355                 360                 365             


Arg Ser Thr Met Leu Glu Leu Glu Lys Gln Gly Leu Glu Ala Met Glu 
    370                 375                 380                 


Glu Ile Leu Thr Ser Ser Glu Pro Leu Asp Pro Ala Glu Val Gly Asp 
385                 390                 395                 400 


Leu Phe Tyr Asp Cys Val Asp Thr Glu Ile Lys Phe Phe Lys 
                405                 410                 


<210> 7185
<211> 214
<212> PRT
<213> Homo sapiens

<400> 7185
Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu 
    130                 135                 140                 


Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr 
145                 150                 155                 160 


Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala 
                165                 170                 175     


His Val Asp Gly Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu 
            180                 185                 190         


Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro 
        195                 200                 205             


Ala Val Asn Ala Arg Leu 
    210                 


<210> 7186
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 7186
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr Ser Ser Pro Val Ala 
    130                 135                 140                 


Ser Gln Pro Ile Phe Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val 
145                 150                 155                 160 


Arg Pro Val Gln Asn Ala Met Asn Gln Val Gly Ile Val Leu Asn Val 
                165                 170                 175     


Gln Gln Gly Gln Thr Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly 
            180                 185                 190         


Thr Gln Phe Val Lys Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln 
        195                 200                 205             


Met Thr Pro Val Arg Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr 
    210                 215                 220                 


Asn Thr Phe Thr Thr Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr 
225                 230                 235                 240 


Val Pro Gln Ser Gln Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser 
                245                 250                 255     


Thr Thr Pro Thr Ala Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val 
            260                 265                 270         


Gln Ser Pro Gly Gln Ser Asn Gln Thr Thr Asn Pro Lys Leu Val Ser 
        275                 280                 285             


Ile Ala Ser Phe Val Thr Val Lys Arg Pro Gly Val Thr Gly Glu Asn 
    290                 295                 300                 


Ser Asn Glu Val Ala Lys Leu Val Asn Thr Leu Asn Thr Ile Pro Ser 
305                 310                 315                 320 


Leu Gly Gln Ser Pro Gly Pro Val Val Val Ser Asn Asn Ser Ser Ala 
                325                 330                 335     


His Gly Ser Gln Arg Thr Ser Gly Pro Glu Ser Ser Met Lys Val Thr 
            340                 345                 350         


Ser Ser Ile Pro Val Phe Asp Leu Gln Asp Gly Gly Arg Lys Ile Cys 
        355                 360                 365             


Pro Arg Cys Asn Ala Gln Phe Arg Val Thr Glu Ala Leu Arg Gly His 
    370                 375                 380                 


Met Cys Tyr Cys Cys Pro Glu Met Val Glu Tyr Gln Lys Lys Gly Lys 
385                 390                 395                 400 


Ser Leu Asp Ser Glu Pro Ser Val Pro Ser Ala Ala Lys Pro Pro Ser 
                405                 410                 415     


Pro Glu Lys Thr Ala Pro Val Ala Ser Thr Pro Ser Ser Thr Pro Ile 
            420                 425                 430         


Pro Ala Leu Ser Pro Pro Thr Lys Val Pro Glu Pro Asn Glu Asn Val 
        435                 440                 445             


Gly Asp Ala Val Gln Thr Lys Leu Ile Met Leu Val Asp Asp Phe Tyr 
    450                 455                 460                 


Tyr Gly Arg Asp Gly Gly Lys Val Ala Gln Leu Thr Asn Phe Pro Lys 
465                 470                 475                 480 


Val Ala Thr Ser Phe Arg Cys Pro His Cys Thr Lys Arg Leu Lys Asn 
                485                 490                 495     


Asn Ile Arg Phe Met Asn His Met Lys His His Val Glu Leu Asp Gln 
            500                 505                 510         


Gln Asn Gly Glu Val Asp Gly His Thr Ile Cys Gln His Cys Tyr Arg 
        515                 520                 525             


Gln Phe Ser Thr Pro Phe Gln Leu Gln Cys His Leu Glu Asn Val His 
    530                 535                 540                 


Ser Pro Tyr Glu Ser Thr Thr Lys Cys Lys Ile Cys Glu Trp Ala Phe 
545                 550                 555                 560 


Glu Ser Glu Pro Leu Phe Leu Gln His Met Lys Asp Thr His Lys Pro 
                565                 570                 575     


Gly Glu Met Pro Tyr Val Cys Gln Val Cys Gln Tyr Arg Ser Ser Leu 
            580                 585                 590         


Tyr Ser Glu Val Asp Val His Phe Arg Met Ile His Glu Asp Thr Arg 
        595                 600                 605             


His Leu Leu Cys Pro Tyr Cys Leu Lys Val Phe Lys Asn Gly Asn Ala 
    610                 615                 620                 


Phe Gln Gln His Tyr Met Arg His Gln Lys Arg Asn Val Tyr His Cys 
625                 630                 635                 640 


Asn Lys Cys Arg Leu Gln Phe Leu Phe Ala Lys Asp Lys Ile Glu His 
                645                 650                 655     


Lys Leu Gln His His Lys Thr Phe Arg Lys Pro Lys Gln Leu Glu Gly 
            660                 665                 670         


Leu Lys Pro Gly Thr Lys Val Thr Ile Arg Ala Ser Arg Gly Gln Pro 
        675                 680                 685             


Arg Thr Val Pro Val Ser Ser Asn Asp Thr Pro Pro Ser Ala Leu Gln 
    690                 695                 700                 


Glu Ala Ala Pro Leu Thr Ser Ser Met Asp Pro Leu Pro Val Phe Leu 
705                 710                 715                 720 


Tyr Pro Pro Val Gln Arg Ser Ile Gln Lys Arg Ala Val Arg Lys Met 
                725                 730                 735     


Ser Val Met Gly Arg Gln Thr Cys Leu Glu Cys Ser Phe Glu Ile Pro 
            740                 745                 750         


Asp Phe Pro Asn His Phe Pro Thr Tyr Val His Cys Ser Leu Cys Arg 
        755                 760                 765             


Tyr Ser Thr Cys Cys Ser Arg Ala Tyr Ala Asn His Met Ile Asn Asn 
    770                 775                 780                 


His Val Pro Arg Lys Ser Pro Lys Tyr Leu Ala Leu Phe Lys Asn Ser 
785                 790                 795                 800 


Val Ser Gly Ile Lys Leu Ala Cys Thr Ser Cys Thr Phe Val Thr Ser 
                805                 810                 815     


Val Gly Asp Ala Met Ala Lys His Leu Val Phe Asn Pro Ser His Arg 
            820                 825                 830         


Ser Ser Ser Ile Leu Pro Arg Gly Leu Thr Trp Ile Ala His Ser Arg 
        835                 840                 845             


His Gly Gln Thr Arg Asp Arg Val His Asp Arg Asn Val Lys Asn Met 
    850                 855                 860                 


Tyr Pro Pro Pro Ser Phe Pro Thr Asn Lys Ala Ala Thr Val Lys Ser 
865                 870                 875                 880 


Ala Gly Ala Thr Pro Ala Glu Pro Glu Glu Leu Leu Thr Pro Leu Ala 
                885                 890                 895     


Pro Ala Leu Pro Ser Pro Ala Ser Thr Ala Thr Pro Pro Pro Thr Pro 
            900                 905                 910         


Thr His Pro Gln Ala Leu Ala Leu Pro Pro Leu Ala Thr Glu Gly Ala 
        915                 920                 925             


Glu Cys Leu Asn Val Asp Asp Gln Asp Glu Gly Ser Pro Val Thr Gln 
    930                 935                 940                 


Glu Pro Glu Leu Ala Ser Gly Gly Gly Gly Ser Gly Gly Val Gly Lys 
945                 950                 955                 960 


Lys Glu Gln Leu Ser Val Lys Lys Leu Arg Val Val Leu Phe Ala Leu 
                965                 970                 975     


Cys Cys Asn Thr Glu Gln Ala Ala Glu His Phe Arg Asn Pro Gln Arg 
            980                 985                 990         


Arg Ile Arg Arg Trp Leu Arg Arg  Phe Gln Ala Ser Gln  Gly Glu Asn 
        995                 1000                 1005             


Leu Glu  Gly Lys Tyr Leu Ser  Phe Glu Ala Glu Glu  Lys Leu Ala 
    1010                 1015                 1020             


Glu Trp  Val Leu Thr Gln Arg  Glu Gln Gln Leu Pro  Val Asn Glu 
    1025                 1030                 1035             


Glu Thr  Leu Phe Gln Lys Ala  Thr Lys Ile Gly Arg  Ser Leu Glu 
    1040                 1045                 1050             


Gly Gly  Phe Lys Ile Ser Tyr  Glu Trp Ala Val Arg  Phe Met Leu 
    1055                 1060                 1065             


Arg His  His Leu Thr Pro His  Ala Arg Arg Ala Val  Ala His Thr 
    1070                 1075                 1080             


Leu Pro  Lys Asp Val Ala Glu  Asn Ala Gly Leu Phe  Ile Asp Phe 
    1085                 1090                 1095             


Val Gln  Arg Gln Ile His Asn  Gln Asp Leu Pro Leu  Ser Met Ile 
    1100                 1105                 1110             


Val Ala  Ile Asp Glu Ile Ser  Leu Phe Leu Asp Thr  Glu Val Leu 
    1115                 1120                 1125             


Ser Ser  Asp Asp Arg Lys Glu  Asn Ala Leu Gln Thr  Val Gly Thr 
    1130                 1135                 1140             


Gly Glu  Pro Trp Cys Asp Val  Val Leu Ala Ile Leu  Ala Asp Gly 
    1145                 1150                 1155             


Thr Val  Leu Pro Thr Leu Val  Phe Tyr Arg Gly Gln  Met Asp Gln 
    1160                 1165                 1170             


Pro Ala  Asn Met Pro Asp Ser  Ile Leu Leu Glu Ala  Lys Glu Ser 
    1175                 1180                 1185             


Gly Tyr  Ser Asp Asp Glu Ile  Met Glu Leu Trp Ser  Thr Arg Val 
    1190                 1195                 1200             


Trp Gln  Lys His Thr Ala Cys  Gln Arg Ser Lys Gly  Met Leu Val 
    1205                 1210                 1215             


Met Asp  Cys His Arg Thr His  Leu Ser Glu Glu Val  Leu Ala Met 
    1220                 1225                 1230             


Leu Ser  Ala Ser Ser Thr Leu  Pro Ala Val Val Pro  Ala Gly Cys 
    1235                 1240                 1245             


Ser Ser  Lys Ile Gln Pro Leu  Asp Val Cys Ile Lys  Arg Thr Val 
    1250                 1255                 1260             


Lys Asn  Phe Leu His Lys Lys  Trp Lys Glu Gln Ala  Arg Glu Met 
    1265                 1270                 1275             


Ala Asp  Thr Ala Cys Asp Ser  Asp Val Leu Leu Gln  Leu Val Leu 
    1280                 1285                 1290             


Val Trp  Leu Gly Glu Val Leu  Gly Val Ile Gly Asp  Cys Pro Glu 
    1295                 1300                 1305             


Leu Val  Gln Arg Ser Phe Leu  Val Ala Ser Val Leu  Pro Gly Pro 
    1310                 1315                 1320             


Asp Gly  Asn Ile Asn Ser Pro  Thr Arg Asn Ala Asp  Met Gln Glu 
    1325                 1330                 1335             


Glu Leu  Ile Ala Ser Leu Glu  Glu Gln Leu Lys Leu  Ser Gly Glu 
    1340                 1345                 1350             


His Ser  Glu Ser Ser Thr Pro  Arg Pro Arg Ser Ser  Pro Glu Glu 
    1355                 1360                 1365             


Thr Ile  Glu Pro Glu Ser Leu  His Gln Leu Phe Glu  Gly Glu Ser 
    1370                 1375                 1380             


Glu Thr  Glu Ser Phe Tyr Gly  Phe Glu Glu Ala Asp  Leu Asp Leu 
    1385                 1390                 1395             


Met Glu  Ile 
    1400     


<210> 7187
<211> 465
<212> PRT
<213> Homo sapiens

<400> 7187
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly 
    290                 295                 300                 


Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu 
305                 310                 315                 320 


Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile 
                325                 330                 335     


Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Ala 
            340                 345                 350         


Thr Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu 
        355                 360                 365             


Glu Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys 
    370                 375                 380                 


Lys Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly 
385                 390                 395                 400 


Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln 
                405                 410                 415     


Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly 
            420                 425                 430         


Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr 
        435                 440                 445             


Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys 
    450                 455                 460                 


Asn 
465 


<210> 7188
<211> 1069
<212> PRT
<213> Homo sapiens

<400> 7188
Met Tyr Leu Leu Asp Gly Ser Gly Glu Pro Ala Ser Pro Pro Ala Asp 
1               5                   10                  15      


Ala Met Pro Arg Gly Thr Pro Pro Arg Lys Thr Val Tyr Arg Ile Ser 
            20                  25                  30          


Val Thr Met Val Arg Lys Glu Gln Leu Ala Ala Pro Gly Ser Gly Gly 
        35                  40                  45              


Pro Asp Pro Arg Pro Val Arg Arg Pro Arg Pro Ala Arg Ser Pro Asp 
    50                  55                  60                  


Ala Pro Gly Arg Leu Glu Glu Glu Ala Glu Glu Ala Glu Gly Ala Glu 
65                  70                  75                  80  


Glu Pro Glu Gly Pro Arg Pro Arg Ala Trp Asp Phe Arg Thr Phe Arg 
                85                  90                  95      


Thr Arg Ser Thr Gly Gln Leu Glu Leu Gly Arg Leu Arg Pro Cys Ala 
            100                 105                 110         


Arg Gly Leu Glu Pro Ala Asp Leu Ala Gly Ser Ala Pro Ala Glu Glu 
        115                 120                 125             


Glu Gly Arg Gly Ser Pro Ala Ser Gly Ser Pro Asp Val Glu Gly Ala 
    130                 135                 140                 


Arg Ala Ala Pro Leu Arg Arg Ser Leu Ser Phe Arg His Trp Ser Gly 
145                 150                 155                 160 


Pro Glu Ala Pro Gln Gly Arg Thr Leu Gly Gly Gly Arg Arg His Ser 
                165                 170                 175     


Ser Ser Gly Ser Leu Ala Trp Ala Pro Cys Asp Glu Ala Ala Ala Gly 
            180                 185                 190         


Thr Thr Leu Glu Pro Ala Thr Ala Thr Gln Pro Ala Ser Glu Lys Arg 
        195                 200                 205             


Asn Thr Leu Asp Val Gly Glu Val Leu Ser Lys Asn Asp Ala Leu Ser 
    210                 215                 220                 


Asp Leu Glu Arg Trp Glu Arg Ser Lys Ser Lys Asn Arg Thr Leu Asp 
225                 230                 235                 240 


Asn Ser Asp Leu Gln Arg Leu Glu Arg Ala Arg Ala Ala Ala Gly Ala 
                245                 250                 255     


Gly Ala Ala Ser Glu His Arg Leu Leu Arg Phe Phe Ser Gly Ile Phe 
            260                 265                 270         


Ala Arg Arg Asp Gly Gly Pro Gly Gly Gly Pro Ser Pro Arg Ser Gly 
        275                 280                 285             


Ala Ser Arg Pro Arg Gly Tyr Phe Ser Leu Arg Arg Ala Pro Ala Glu 
    290                 295                 300                 


Ala His Ser Ser Ser Ala Glu Ser Ile Asp Gly Ser Pro Arg Arg Asp 
305                 310                 315                 320 


Ala Phe Val Asn Ser Gln Glu Trp Thr Leu Ser Arg Ser Val Pro Glu 
                325                 330                 335     


Leu Lys Val Gly Ile Val Gly Asn Leu Ala Ser Gly Lys Ser Ala Leu 
            340                 345                 350         


Val His Arg Tyr Leu Thr Gly Thr Tyr Val Gln Glu Glu Ser Pro Glu 
        355                 360                 365             


Gly Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu 
    370                 375                 380                 


Leu Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Ala Gln Phe Ala Met 
385                 390                 395                 400 


Trp Val Asp Ala Val Ile Phe Val Phe Ser Leu Glu Asp Glu Ile Ser 
                405                 410                 415     


Phe Gln Thr Val Tyr His Tyr Tyr Ser Arg Met Ala Asn Tyr Arg Asn 
            420                 425                 430         


Thr Ser Glu Ile Pro Leu Val Leu Val Gly Thr Gln Asp Ala Ile Ser 
        435                 440                 445             


Ser Ala Asn Pro Arg Val Ile Asp Asp Ala Arg Ala Arg Lys Leu Ser 
    450                 455                 460                 


Asn Asp Leu Lys Arg Cys Thr Tyr Tyr Glu Thr Cys Ala Thr Tyr Gly 
465                 470                 475                 480 


Leu Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Ile Val Ala 
                485                 490                 495     


Thr Arg Lys Lys Gln Gln Leu Ser Ile Gly Pro Cys Lys Ser Leu Pro 
            500                 505                 510         


Asn Ser Pro Ser His Ser Ser Val Cys Ser Ala Gln Val Ser Ala Val 
        515                 520                 525             


His Ile Ser Gln Thr Ser Asn Gly Gly Gly Ser Leu Ser Asp Tyr Ser 
    530                 535                 540                 


Ser Ser Val Pro Ser Thr Pro Ser Thr Ser Gln Lys Glu Leu Arg Ile 
545                 550                 555                 560 


Asp Val Pro Pro Thr Ala Asn Thr Pro Thr Pro Val Arg Lys Gln Ser 
                565                 570                 575     


Lys Arg Arg Ser Asn Leu Phe Thr Ser Arg Lys Gly Ser Asp Pro Asp 
            580                 585                 590         


Lys Glu Lys Lys Gly Leu Glu Ser Arg Ala Asp Ser Ile Gly Ser Gly 
        595                 600                 605             


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
    610                 615                 620                 


Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Thr Leu Cys Asp Asn 
625                 630                 635                 640 


Gly Val Leu Thr Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Val 
                645                 650                 655     


His Gly Lys Glu Ile Asp Leu Leu Arg Thr Thr Val Lys Val Pro Gly 
            660                 665                 670         


Lys Arg Pro Pro Arg Ala Thr Ser Ala Cys Ala Pro Ile Ser Ser Pro 
        675                 680                 685             


Lys Thr Asn Gly Leu Ser Lys Asp Met Ser Ser Leu His Ile Ser Pro 
    690                 695                 700                 


Asn Ser Asp Thr Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile 
705                 710                 715                 720 


Ser Ser Thr Thr Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala 
                725                 730                 735     


Asn Arg Lys Lys His Arg Arg Lys Lys Ser Thr Ser Asn Phe Lys Ala 
            740                 745                 750         


Asp Gly Leu Ser Gly Thr Ala Glu Glu Gln Glu Glu Asn Phe Glu Phe 
        755                 760                 765             


Ile Ile Val Ser Leu Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr 
    770                 775                 780                 


Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu 
785                 790                 795                 800 


Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Thr 
                805                 810                 815     


Ser Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly 
            820                 825                 830         


Asn Ser His Cys Val Asp Cys Glu Thr Gln Asn Pro Asn Trp Ala Ser 
        835                 840                 845             


Leu Asn Leu Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg 
    850                 855                 860                 


Asn Leu Gly Thr His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp 
865                 870                 875                 880 


Trp Pro Val Glu Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu 
                885                 890                 895     


Ala Asn Ser Val Trp Glu Glu Ser Ser Gln Gly Arg Thr Lys Pro Ser 
            900                 905                 910         


Val Asp Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr 
        915                 920                 925             


Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu 
    930                 935                 940                 


Gly Gln His Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Arg Thr Ala 
945                 950                 955                 960 


Ile Leu Leu Leu Ala His Gly Ser Arg Asp Glu Val Asn Glu Thr Cys 
                965                 970                 975     


Gly Glu Gly Asp Gly Arg Thr Ala Leu His Leu Ala Cys Arg Lys Gly 
            980                 985                 990         


Asn Val Val Leu Ala Gln Leu Leu  Ile Trp Tyr Gly Val  Asp Val Thr 
        995                 1000                 1005             


Ala Arg  Asp Ala His Gly Asn  Thr Ala Leu Ala Tyr  Ala Arg Gln 
    1010                 1015                 1020             


Ala Ser  Ser Gln Glu Cys Ile  Asp Val Leu Leu Gln  Tyr Gly Cys 
    1025                 1030                 1035             


Pro Asp  Glu Arg Phe Val Leu  Met Ala Thr Pro Asn  Leu Ser Arg 
    1040                 1045                 1050             


Arg Asn  Asn Asn Arg Asn Asn  Ser Ser Gly Arg Val  Pro Thr Ile 
    1055                 1060                 1065             


Ile 
    


<210> 7189
<211> 419
<212> PRT
<213> Homo sapiens

<400> 7189
Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe 
1               5                   10                  15      


Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe 
            20                  25                  30          


Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu 
        35                  40                  45              


Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg 
    50                  55                  60                  


Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu 
65                  70                  75                  80  


Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys 
                85                  90                  95      


Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln 
            100                 105                 110         


Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe 
        115                 120                 125             


Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu 
    130                 135                 140                 


Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn 
145                 150                 155                 160 


Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu 
                165                 170                 175     


Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser 
            180                 185                 190         


Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys 
        195                 200                 205             


Val Ser Met Asp Asn Arg Leu Met Glu Leu Phe Pro Ala Asn Lys Gln 
    210                 215                 220                 


Ser Val Glu His Phe Thr Lys Tyr Phe Thr Glu Ala Gly Leu Lys Glu 
225                 230                 235                 240 


Leu Ser Glu Tyr Val Arg Asn Gln Gln Thr Ile Gly Ala Arg Lys Glu 
                245                 250                 255     


Leu Gln Lys Glu Leu Gln Glu Gln Met Ser Arg Gly Asp Pro Phe Lys 
            260                 265                 270         


Asp Ile Ile Leu Tyr Val Lys Glu Glu Met Lys Lys Asn Asn Ile Pro 
        275                 280                 285             


Glu Pro Val Val Ile Gly Ile Val Trp Ser Ser Val Met Ser Thr Val 
    290                 295                 300                 


Glu Trp Asn Lys Lys Glu Glu Leu Val Ala Glu Gln Ala Ile Lys His 
305                 310                 315                 320 


Leu Lys Gln Tyr Ser Pro Leu Leu Ala Ala Phe Thr Thr Gln Gly Gln 
                325                 330                 335     


Ser Glu Leu Thr Leu Leu Leu Lys Ile Gln Glu Tyr Cys Tyr Asp Asn 
            340                 345                 350         


Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val Leu Phe Tyr Lys 
        355                 360                 365             


Ala Glu Val Leu Ser Glu Glu Pro Ile Leu Lys Trp Tyr Lys Asp Ala 
    370                 375                 380                 


His Val Ala Lys Gly Lys Ser Val Phe Leu Glu Gln Met Lys Lys Phe 
385                 390                 395                 400 


Val Glu Trp Leu Lys Asn Ala Glu Glu Glu Ser Glu Ser Glu Ala Glu 
                405                 410                 415     


Glu Gly Asp 
            


<210> 7190
<211> 922
<212> PRT
<213> Homo sapiens

<400> 7190
Met Ile Thr Ser Ala Ala Gly Ile Ile Ser Leu Leu Asp Glu Asp Glu 
1               5                   10                  15      


Pro Gln Leu Lys Glu Phe Ala Leu His Lys Leu Asn Ala Val Val Asn 
            20                  25                  30          


Asp Phe Trp Ala Glu Ile Ser Glu Ser Val Asp Lys Ile Glu Val Leu 
        35                  40                  45              


Tyr Glu Asp Glu Gly Phe Arg Ser Arg Gln Phe Ala Ala Leu Val Ala 
    50                  55                  60                  


Ser Lys Val Phe Tyr His Leu Gly Ala Phe Glu Glu Ser Leu Asn Tyr 
65                  70                  75                  80  


Ala Leu Gly Ala Gly Asp Leu Phe Asn Val Asn Asp Asn Ser Glu Tyr 
                85                  90                  95      


Val Glu Thr Ile Ile Ala Lys Cys Ile Asp His Tyr Thr Lys Gln Cys 
            100                 105                 110         


Val Glu Asn Ala Asp Leu Pro Glu Gly Glu Lys Lys Pro Ile Asp Gln 
        115                 120                 125             


Arg Leu Glu Gly Ile Val Asn Lys Met Phe Gln Arg Cys Leu Asp Asp 
    130                 135                 140                 


His Lys Tyr Lys Gln Ala Ile Gly Ile Ala Leu Glu Thr Arg Arg Leu 
145                 150                 155                 160 


Asp Val Phe Glu Lys Thr Ile Leu Glu Ser Asn Asp Val Pro Gly Met 
                165                 170                 175     


Leu Ala Tyr Ser Leu Lys Leu Cys Met Ser Leu Met Gln Asn Lys Gln 
            180                 185                 190         


Phe Arg Asn Lys Val Leu Arg Val Leu Val Lys Ile Tyr Met Asn Leu 
        195                 200                 205             


Glu Lys Pro Asp Phe Ile Asn Val Cys Gln Cys Leu Ile Phe Leu Asp 
    210                 215                 220                 


Asp Pro Gln Ala Val Ser Asp Ile Leu Glu Lys Leu Val Lys Glu Asp 
225                 230                 235                 240 


Asn Leu Leu Met Ala Tyr Gln Ile Cys Phe Asp Leu Tyr Glu Ser Ala 
                245                 250                 255     


Ser Gln Gln Phe Leu Ser Ser Val Ile Gln Asn Leu Arg Thr Val Gly 
            260                 265                 270         


Thr Pro Ile Ala Ser Val Pro Gly Ser Thr Asn Thr Gly Thr Val Pro 
        275                 280                 285             


Gly Ser Glu Lys Asp Ser Asp Ser Met Glu Thr Glu Glu Lys Thr Ser 
    290                 295                 300                 


Ser Ala Phe Val Gly Lys Thr Pro Glu Ala Ser Pro Glu Pro Lys Asp 
305                 310                 315                 320 


Gln Thr Leu Lys Met Ile Lys Ile Leu Ser Gly Glu Met Ala Ile Glu 
                325                 330                 335     


Leu His Leu Gln Phe Leu Ile Arg Asn Asn Asn Thr Asp Leu Met Ile 
            340                 345                 350         


Leu Lys Asn Thr Lys Asp Ala Val Arg Asn Ser Val Cys His Thr Ala 
        355                 360                 365             


Thr Val Ile Ala Asn Ser Phe Met His Cys Gly Thr Thr Ser Asp Gln 
    370                 375                 380                 


Phe Leu Arg Asp Asn Leu Glu Trp Leu Ala Arg Ala Thr Asn Trp Ala 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Ala Ser Leu Gly Val Ile His Lys Gly His Glu 
                405                 410                 415     


Lys Glu Ala Leu Gln Leu Met Ala Thr Tyr Leu Pro Lys Asp Thr Ser 
            420                 425                 430         


Pro Gly Ser Ala Tyr Gln Glu Gly Gly Gly Leu Tyr Ala Leu Gly Leu 
        435                 440                 445             


Ile His Ala Asn His Gly Gly Asp Ile Ile Asp Tyr Leu Leu Asn Gln 
    450                 455                 460                 


Leu Lys Asn Ala Ser Asn Asp Ile Val Arg His Gly Gly Ser Leu Gly 
465                 470                 475                 480 


Leu Gly Leu Ala Ala Met Gly Thr Ala Arg Gln Asp Val Tyr Asp Leu 
                485                 490                 495     


Leu Lys Thr Asn Leu Tyr Gln Asp Asp Ala Val Thr Gly Glu Ala Ala 
            500                 505                 510         


Gly Leu Ala Leu Gly Leu Val Met Leu Gly Ser Lys Asn Ala Gln Ala 
        515                 520                 525             


Ile Glu Asp Met Val Gly Tyr Ala Gln Glu Thr Gln His Glu Lys Ile 
    530                 535                 540                 


Leu Arg Gly Leu Ala Val Gly Ile Ala Leu Val Met Tyr Gly Arg Met 
545                 550                 555                 560 


Glu Glu Ala Asp Ala Leu Ile Glu Ser Leu Cys Arg Asp Lys Asp Pro 
                565                 570                 575     


Ile Leu Arg Arg Ser Gly Met Tyr Thr Val Ala Met Ala Tyr Cys Gly 
            580                 585                 590         


Ser Gly Asn Asn Lys Ala Ile Arg Arg Leu Leu His Val Ala Val Ser 
        595                 600                 605             


Asp Val Asn Asp Asp Val Arg Arg Ala Ala Val Glu Ser Leu Gly Phe 
    610                 615                 620                 


Ile Leu Phe Arg Thr Pro Glu Gln Cys Pro Ser Val Val Ser Leu Leu 
625                 630                 635                 640 


Ser Glu Ser Tyr Asn Pro His Val Arg Tyr Gly Ala Ala Met Ala Leu 
                645                 650                 655     


Gly Ile Cys Cys Ala Gly Thr Gly Asn Lys Glu Ala Ile Asn Leu Leu 
            660                 665                 670         


Glu Pro Met Thr Asn Asp Pro Val Asn Tyr Val Arg Gln Gly Ala Leu 
        675                 680                 685             


Ile Ala Ser Ala Leu Ile Met Ile Gln Gln Thr Glu Ile Thr Cys Pro 
    690                 695                 700                 


Lys Val Asn Gln Phe Arg Gln Leu Tyr Ser Lys Val Ile Asn Asp Lys 
705                 710                 715                 720 


His Asp Asp Val Met Ala Lys Phe Gly Ala Ile Leu Ala Gln Gly Ile 
                725                 730                 735     


Leu Asp Ala Gly Gly His Asn Val Thr Ile Ser Leu Gln Ser Arg Thr 
            740                 745                 750         


Gly His Thr His Met Pro Ser Val Val Gly Val Leu Val Phe Thr Gln 
        755                 760                 765             


Phe Trp Phe Trp Phe Pro Leu Ser His Phe Leu Ser Leu Ala Tyr Thr 
    770                 775                 780                 


Pro Thr Cys Val Ile Gly Leu Asn Lys Asp Leu Lys Val Ser Thr Ala 
785                 790                 795                 800 


Val Leu Ser Ile Thr Ala Lys Ala Lys Lys Lys Glu Lys Glu Lys Glu 
                805                 810                 815     


Lys Lys Glu Glu Glu Lys Met Glu Val Asp Glu Ala Glu Lys Lys Glu 
            820                 825                 830         


Glu Lys Glu Lys Lys Lys Glu Pro Glu Pro Asn Phe Gln Leu Leu Asp 
        835                 840                 845             


Asn Pro Ala Arg Val Met Pro Ala Gln Leu Lys Val Leu Thr Met Pro 
    850                 855                 860                 


Glu Thr Cys Arg Tyr Gln Pro Phe Lys Pro Leu Ser Ile Gly Gly Ile 
865                 870                 875                 880 


Ile Ile Leu Lys Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro 
                885                 890                 895     


Val Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu 
            900                 905                 910         


Pro Pro Glu Pro Phe Glu Tyr Ile Asp Asp 
        915                 920         


<210> 7191
<211> 120
<212> PRT
<213> Homo sapiens

<400> 7191
Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Asn Cys His His Gln 
        115                 120 


<210> 7192
<211> 125
<212> PRT
<213> Homo sapiens

<400> 7192
Met Ser Ser Thr Leu Gly Lys Leu Ser Asn Gln Val Glu Glu Thr Leu 
1               5                   10                  15      


Pro Leu Leu Lys Lys Val Pro Ala Asn Tyr Phe His Ile Cys Ser Ala 
            20                  25                  30          


Ile Leu Met Gly Phe Ser Leu Ser Lys Ser Ala Thr Gln Val Ser Ala 
        35                  40                  45              


Ile His Met Asp Ser Lys Val Asp Asp His Leu Ile Arg Gly Thr Glu 
    50                  55                  60                  


Lys Ser Arg Leu Glu Pro Ala Thr Gln Leu Phe Gln Asn Thr Lys Lys 
65                  70                  75                  80  


Ile Arg Leu Glu Asp Thr Asn Gln Glu Asn Phe Thr Arg Ile Glu Gly 
                85                  90                  95      


Thr Gly Thr Gly Ser Leu Ser Gly Lys Ala Leu Gly Ser Val Val Tyr 
            100                 105                 110         


Val Lys Glu Ser Asp Gly Leu Glu Met Thr Asp Val Glu 
        115                 120                 125 


<210> 7193
<211> 499
<212> PRT
<213> Homo sapiens

<400> 7193
Met Ser Thr Pro Ser Gly Ile Ser Thr Trp Leu Ser Leu Pro Val Ser 
1               5                   10                  15      


Thr Pro Ala Ser Ile Thr Ser Ile Arg Val Thr Gln Lys Ser Ser Gly 
            20                  25                  30          


Pro Trp Ala Phe Ser Ser Cys Thr Tyr Val Ser Gly Pro Gly Val Cys 
        35                  40                  45              


Ile Ser Ser Leu Ser Cys Ser Arg Val Gly Ser Ser Ser Phe Arg Gly 
    50                  55                  60                  


Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Ile 
65                  70                  75                  80  


Ala Ile Met Val Asn Gln Ser Leu Leu Ser Pro Leu Asn Leu Glu Val 
                85                  90                  95      


Asp Pro Asn Ile Gln Ala Val Cys Thr Gln Glu Lys Glu Gln Ile Lys 
            100                 105                 110         


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Trp Phe Leu 
        115                 120                 125             


Glu Gln Gln Asn Lys Val Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln 
    130                 135                 140                 


Gln Lys Met Ala Arg Ser Asn Met Asp Asn Met Leu Glu Ser Tyr Ile 
145                 150                 155                 160 


Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys 
                165                 170                 175     


Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Gly Glu Asp Phe Lys 
            180                 185                 190         


Asn Lys Tyr Glu Asp Glu Ile Asn Lys His Thr Glu Val Glu Asn Glu 
        195                 200                 205             


Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Ala 
    210                 215                 220                 


Glu Leu Glu Ser Leu Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu 
225                 230                 235                 240 


Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser 
                245                 250                 255     


Asp Met Ser Met Val Leu Ser Met Asp Tyr Ser Cys Ser Arg Asp Met 
            260                 265                 270         


Asp Ser Ile Ile Pro Glu Val Lys Val Gln Tyr Glu Glu Ile Ala Asn 
        275                 280                 285             


Cys Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu 
    290                 295                 300                 


Leu Gln Thr Leu Ala Gly Lys Tyr Gly Asp Asp Leu Ser Arg Thr Lys 
305                 310                 315                 320 


Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Trp Leu Gln Ala Glu 
                325                 330                 335     


Thr Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Thr 
            340                 345                 350         


Asp Ala Glu Gln Arg Gly Glu Leu Ala Val Lys Asp Ala Asn Ala Lys 
        355                 360                 365             


Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Met 
    370                 375                 380                 


Gly Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Gly Leu Thr Leu 
385                 390                 395                 400 


Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser 
                405                 410                 415     


Arg Leu Glu Ser Gly Met Gln Asn Val Ser Ile His Thr Lys Thr Thr 
            420                 425                 430         


Ser Ser Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser 
        435                 440                 445             


Pro Gly Ile Ile Tyr Arg Leu Gly Ser Ser Phe Gly Ser Ala Ala Gly 
    450                 455                 460                 


Ser Ser Ser Phe Ser Arg Thr Ser Ser Thr Arg Ala Val Val Val Arg 
465                 470                 475                 480 


Lys Ile Glu Thr His Asp Gly Lys Leu Glu Ser Glu Ser Ser Asp Val 
                485                 490                 495     


Leu Ser Lys 
            


<210> 7194
<211> 167
<212> PRT
<213> Homo sapiens

<400> 7194
Met Tyr Met Gly Met Met Cys Thr Ala Lys Lys Cys Gly Ile Arg Phe 
1               5                   10                  15      


Gln Pro Pro Ala Ile Ile Leu Ile Tyr Glu Ser Glu Ile Lys Gly Lys 
            20                  25                  30          


Ile Arg Gln Arg Ile Met Pro Val Arg Asn Phe Ser Lys Phe Ser Asp 
        35                  40                  45              


Cys Thr Arg Ala Ala Glu Gln Leu Lys Asn Asn Pro Arg His Lys Ser 
    50                  55                  60                  


Tyr Leu Glu Gln Val Ser Leu Arg Gln Leu Glu Lys Leu Phe Ser Phe 
65                  70                  75                  80  


Leu Arg Gly Tyr Leu Ser Gly Gln Ser Leu Ala Glu Thr Met Glu Gln 
                85                  90                  95      


Ile Gln Arg Glu Thr Thr Ile Asp Pro Glu Glu Asp Leu Asn Lys Leu 
            100                 105                 110         


Asp Asp Lys Glu Leu Ala Lys Arg Lys Ser Ile Met Asp Glu Leu Phe 
        115                 120                 125             


Glu Lys Asn Gln Lys Lys Lys Asp Asp Pro Asn Phe Val Tyr Asp Ile 
    130                 135                 140                 


Glu Val Glu Phe Pro Gln Asp Asp Gln Leu Gln Ser Cys Gly Trp Asp 
145                 150                 155                 160 


Thr Glu Ser Ala Asp Glu Phe 
                165         


<210> 7195
<211> 125
<212> PRT
<213> Homo sapiens

<400> 7195
Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn 
        115                 120                 125 


<210> 7196
<211> 334
<212> PRT
<213> Homo sapiens

<400> 7196
Met Thr Arg Ser Leu Phe Lys Gly Asn Phe Trp Ser Ala Asp Ile Leu 
1               5                   10                  15      


Ser Thr Ile Gly Tyr Asp Asn Ile Ile Gln His Leu Asn Asn Gly Arg 
            20                  25                  30          


Lys Asn Cys Lys Glu Phe Glu Asp Phe Leu Lys Glu Arg Ala Ala Ile 
        35                  40                  45              


Glu Glu Arg Tyr Gly Lys Asp Leu Leu Asn Leu Ser Arg Lys Lys Pro 
    50                  55                  60                  


Cys Gly Gln Ser Glu Ile Asn Thr Leu Lys Arg Ala Leu Glu Val Phe 
65                  70                  75                  80  


Lys Gln Gln Val Asp Asn Val Ala Gln Cys His Ile Gln Leu Ala Gln 
                85                  90                  95      


Ser Leu Arg Glu Glu Ala Arg Lys Met Glu Glu Phe Arg Glu Lys Gln 
            100                 105                 110         


Lys Leu Gln Arg Lys Lys Thr Glu Leu Ile Met Asp Ala Ile His Lys 
        115                 120                 125             


Gln Lys Ser Leu Gln Phe Lys Lys Thr Met Asp Ala Lys Lys Asn Tyr 
    130                 135                 140                 


Glu Gln Lys Cys Arg Asp Lys Asp Glu Ala Glu Gln Ala Val Ser Arg 
145                 150                 155                 160 


Ser Ala Asn Leu Val Asn Pro Lys Gln Gln Glu Lys Leu Phe Val Lys 
                165                 170                 175     


Leu Ala Thr Ser Lys Thr Ala Val Glu Asp Ser Asp Lys Ala Tyr Met 
            180                 185                 190         


Leu His Ile Gly Thr Leu Asp Lys Val Arg Glu Glu Trp Gln Ser Glu 
        195                 200                 205             


His Ile Lys Ala Cys Glu Ala Phe Glu Ala Gln Glu Cys Glu Arg Ile 
    210                 215                 220                 


Asn Phe Phe Arg Asn Ala Leu Trp Leu His Val Asn Gln Leu Ser Gln 
225                 230                 235                 240 


Gln Cys Val Thr Ser Asp Glu Met Tyr Glu Gln Val Arg Lys Ser Leu 
                245                 250                 255     


Glu Met Cys Ser Ile Gln Arg Asp Ile Glu Tyr Phe Val Asn Gln Arg 
            260                 265                 270         


Lys Thr Gly Gln Ile Pro Pro Ala Pro Ile Met Tyr Glu Asn Phe Tyr 
        275                 280                 285             


Ser Ser Gln Lys Asn Ala Val Pro Ala Gly Lys Ala Thr Gly Pro Asn 
    290                 295                 300                 


Leu Ala Arg Arg Gly Pro Leu Pro Ile Pro Lys Ser Ser Pro Asp Asp 
305                 310                 315                 320 


Pro Asn Tyr Ser Leu Val Asp Asp Tyr Ser Leu Leu Tyr Gln 
                325                 330                 


<210> 7197
<211> 198
<212> PRT
<213> Homo sapiens

<400> 7197
Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val 
1               5                   10                  15      


Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg 
            20                  25                  30          


Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp 
        35                  40                  45              


Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val 
    50                  55                  60                  


Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe 
65                  70                  75                  80  


Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu 
                85                  90                  95      


Phe Glu Leu Thr Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu 
            100                 105                 110         


Ser Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro 
        115                 120                 125             


Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr 
    130                 135                 140                 


Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser 
145                 150                 155                 160 


Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile 
                165                 170                 175     


Asp Ile Ile Ala Glu Leu Arg Tyr Asp Leu Pro Ala Ser Tyr Lys Phe 
            180                 185                 190         


His Lys Lys Lys Ser Val 
        195             


<210> 7198
<211> 374
<212> PRT
<213> Homo sapiens

<400> 7198
Met Leu Ala Pro Gly Cys Glu Leu Asp Pro Asp Gln Glu Val Val Arg 
1               5                   10                  15      


Thr Arg Pro Glu Asp Val Pro Ala Ser Pro Ser Thr Ser Thr Met Ile 
            20                  25                  30          


Val Ser Val Leu Arg Pro Pro Ser His Ala Ser Cys Thr Ala Cys Gly 
        35                  40                  45              


Thr Val Thr Phe His Ile Val Glu Arg Met Ala Ser Val Ile Pro Ala 
    50                  55                  60                  


Ser Asn Arg Ser Met Arg Ser Asp Arg Asn Thr Tyr Val Gly Lys Arg 
65                  70                  75                  80  


Phe Val His Val Lys Asn Pro Tyr Leu Asp Leu Met Asp Glu Asp Ile 
                85                  90                  95      


Leu Tyr His Leu Asp Leu Gly Thr Lys Thr His Asn Leu Pro Ala Met 
            100                 105                 110         


Phe Gly Asp Val Lys Phe Val Cys Val Gly Gly Ser Pro Asn Arg Met 
        115                 120                 125             


Lys Ala Phe Ala Leu Phe Met His Lys Glu Leu Gly Phe Glu Glu Ala 
    130                 135                 140                 


Glu Glu Asp Ile Lys Asp Ile Cys Ala Gly Thr Asp Arg Tyr Cys Met 
145                 150                 155                 160 


Tyr Lys Thr Gly Pro Val Leu Ala Ile Ser His Gly Met Gly Ile Pro 
                165                 170                 175     


Ser Ile Ser Ile Met Leu His Glu Leu Ile Lys Leu Leu His His Ala 
            180                 185                 190         


Arg Cys Cys Asp Val Thr Ile Ile Arg Ile Gly Thr Ser Gly Gly Ile 
        195                 200                 205             


Gly Ile Ala Pro Gly Thr Val Val Ile Thr Asp Ile Ala Val Asp Ser 
    210                 215                 220                 


Phe Phe Lys Pro Arg Phe Glu Gln Val Ile Leu Asp Asn Ile Val Thr 
225                 230                 235                 240 


Arg Ser Thr Glu Leu Asp Lys Glu Leu Ser Glu Glu Leu Phe Asn Cys 
                245                 250                 255     


Ser Lys Glu Ile Pro Asn Phe Pro Thr Leu Val Gly His Thr Met Cys 
            260                 265                 270         


Thr Tyr Asp Phe Tyr Glu Gly Gln Gly Arg Leu Asp Gly Ala Leu Cys 
        275                 280                 285             


Ser Phe Ser Arg Glu Lys Lys Leu Asp Tyr Leu Lys Arg Ala Phe Lys 
    290                 295                 300                 


Ala Gly Val Arg Asn Ile Glu Met Glu Ser Thr Val Phe Ala Ala Met 
305                 310                 315                 320 


Cys Gly Leu Cys Gly Leu Lys Ala Ala Val Val Cys Val Thr Leu Leu 
                325                 330                 335     


Asp Arg Leu Asp Cys Asp Gln Ile Asn Leu Pro His Asp Val Leu Val 
            340                 345                 350         


Glu Tyr Gln Gln Arg Pro Gln Leu Leu Ile Ser Asn Phe Ile Arg Arg 
        355                 360                 365             


Arg Leu Gly Leu Cys Asp 
    370                 


<210> 7199
<211> 1382
<212> PRT
<213> Homo sapiens

<400> 7199
Met Leu Arg Lys Leu Thr Ile Glu Gln Ile Asn Asp Trp Phe Thr Ile 
1               5                   10                  15      


Gly Lys Thr Val Thr Asn Val Glu Leu Leu Gly Ala Pro Pro Ala Phe 
            20                  25                  30          


Pro Ala Gly Ala Ala Arg Glu Glu Val Gln Arg Gln Asp Val Ala Pro 
        35                  40                  45              


Gly Ala Gly Pro Ala Ala Gln Ala Pro Ala Leu Ala Gln Ala Pro Ala 
    50                  55                  60                  


Arg Pro Ala Ala Ala Phe Glu Arg Ser Leu Ser Gln Arg Ser Ser Glu 
65                  70                  75                  80  


Val Glu Tyr Ile Asn Lys Tyr Arg Gln Leu Glu Ala Gln Glu Leu Asp 
                85                  90                  95      


Val Cys Arg Ser Val Gln Pro Thr Ser Gly Pro Gly Pro Arg Pro Ser 
            100                 105                 110         


Leu Ala Lys Leu Ser Ser Val Thr Cys Ile Pro Gly Thr Thr Tyr Lys 
        115                 120                 125             


Tyr Pro Asp Leu Pro Ile Ser Arg Tyr Lys Glu Glu Val Val Ser Leu 
    130                 135                 140                 


Ile Glu Ser Asn Ser Val Val Ile Ile His Gly Ala Thr Gly Ser Gly 
145                 150                 155                 160 


Lys Ser Thr Gln Leu Pro Gln Tyr Ile Leu Asp His Tyr Val Gln Arg 
                165                 170                 175     


Ser Ala Tyr Cys Ser Ile Val Val Thr Gln Pro Arg Lys Ile Gly Ala 
            180                 185                 190         


Ser Ser Ile Ala Arg Trp Ile Ser Lys Glu Arg Ala Trp Thr Leu Gly 
        195                 200                 205             


Gly Val Val Gly Tyr Gln Val Gly Leu Glu Lys Ile Ala Thr Glu Asp 
    210                 215                 220                 


Thr Arg Leu Ile Tyr Met Thr Thr Gly Val Leu Leu Gln Lys Ile Val 
225                 230                 235                 240 


Ser Ala Lys Ser Leu Met Glu Phe Thr His Ile Ile Ile Asp Glu Val 
                245                 250                 255     


His Glu Arg Thr Glu Glu Met Asp Phe Leu Leu Leu Val Val Arg Lys 
            260                 265                 270         


Leu Leu Arg Thr Asn Ser Arg Phe Val Lys Val Val Leu Met Ser Ala 
        275                 280                 285             


Thr Ile Ser Cys Lys Glu Phe Ala Asp Tyr Phe Ala Val Pro Val Gln 
    290                 295                 300                 


Asn Lys Met Asn Pro Ala Tyr Ile Phe Glu Val Glu Gly Lys Pro His 
305                 310                 315                 320 


Ser Val Glu Glu Tyr Tyr Leu Asn Asp Leu Glu His Ile His His Ser 
                325                 330                 335     


Lys Leu Ser Pro His Leu Leu Glu Glu Pro Val Ile Thr Lys Asp Ile 
            340                 345                 350         


Tyr Glu Val Ala Val Ser Leu Ile Gln Met Phe Asp Asp Leu Asp Met 
        355                 360                 365             


Lys Glu Ser Gly Asn Lys Ala Trp Ser Gly Ala Gln Phe Val Leu Glu 
    370                 375                 380                 


Arg Ser Ser Val Leu Val Phe Leu Pro Gly Leu Gly Glu Ile Asn Tyr 
385                 390                 395                 400 


Met His Glu Leu Leu Thr Ser Leu Val His Lys Arg Leu Gln Val Tyr 
                405                 410                 415     


Pro Leu His Ser Ser Val Ala Leu Glu Glu Gln Asn Asn Val Phe Leu 
            420                 425                 430         


Ser Pro Val Pro Gly Tyr Arg Lys Ile Ile Leu Ser Thr Asn Ile Ala 
        435                 440                 445             


Glu Ser Ser Val Thr Val Pro Asp Val Lys Tyr Val Ile Asp Phe Cys 
    450                 455                 460                 


Leu Thr Arg Thr Leu Val Cys Asp Glu Asp Thr Asn Tyr Gln Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Trp Ala Ser Lys Thr Ser Cys Asn Gln Arg Lys Gly Arg 
                485                 490                 495     


Ala Gly Arg Val Ser Arg Gly Tyr Cys Tyr Arg Leu Val His Lys Asp 
            500                 505                 510         


Phe Trp Asp Asn Ser Ile Pro Asp His Val Val Pro Glu Met Leu Arg 
        515                 520                 525             


Cys Pro Leu Gly Ser Thr Ile Leu Lys Val Lys Leu Leu Asp Met Gly 
    530                 535                 540                 


Glu Pro Arg Ala Leu Leu Ala Thr Ala Leu Ser Pro Pro Gly Leu Ser 
545                 550                 555                 560 


Asp Ile Glu Arg Thr Ile Leu Leu Leu Lys Glu Val Gly Ala Leu Ala 
                565                 570                 575     


Val Ser Gly Gln Arg Glu Asp Glu Asn Pro His Asp Gly Glu Leu Thr 
            580                 585                 590         


Phe Leu Gly Arg Val Leu Ala Gln Leu Pro Val Asn Gln Gln Leu Gly 
        595                 600                 605             


Lys Leu Ile Val Leu Gly His Val Phe Gly Cys Leu Asp Glu Cys Leu 
    610                 615                 620                 


Ile Ile Ala Ala Ala Leu Ser Leu Lys Asn Phe Phe Ala Met Pro Phe 
625                 630                 635                 640 


Arg Gln His Leu Asp Gly Tyr Arg Asn Lys Val Asn Phe Ser Gly Ser 
                645                 650                 655     


Ser Lys Ser Asp Cys Ile Ala Leu Val Glu Ala Phe Lys Thr Trp Lys 
            660                 665                 670         


Ala Cys Arg Gln Thr Gly Glu Leu Arg Tyr Pro Lys Asp Glu Leu Asn 
        675                 680                 685             


Trp Gly Arg Leu Asn Tyr Ile Gln Ile Lys Arg Ile Arg Glu Val Ala 
    690                 695                 700                 


Glu Leu Tyr Glu Glu Leu Lys Thr Arg Ile Ser Gln Phe Asn Met His 
705                 710                 715                 720 


Val Asp Ser Arg Arg Pro Val Met Asp Gln Glu Tyr Ile Tyr Lys Gln 
                725                 730                 735     


Arg Phe Ile Leu Gln Val Val Leu Ala Gly Ala Phe Tyr Pro Asn Tyr 
            740                 745                 750         


Phe Thr Phe Gly Gln Pro Asp Glu Glu Met Ala Val Arg Glu Leu Ala 
        755                 760                 765             


Gly Lys Asp Pro Lys Thr Thr Val Val Leu Lys His Ile Pro Pro Tyr 
    770                 775                 780                 


Gly Phe Leu Tyr Tyr Lys Gln Leu Gln Ser Leu Phe Arg Gln Cys Gly 
785                 790                 795                 800 


Gln Val Lys Ser Ile Val Phe Asp Gly Ala Lys Ala Phe Val Glu Phe 
                805                 810                 815     


Ser Arg Asn Pro Thr Glu Arg Phe Lys Thr Leu Pro Ala Val Tyr Met 
            820                 825                 830         


Ala Ile Lys Met Ser Gln Leu Lys Val Ser Leu Glu Leu Ser Val His 
        835                 840                 845             


Ser Ala Glu Glu Ile Glu Gly Lys Val Gln Gly Met Asn Val Ser Lys 
    850                 855                 860                 


Leu Arg Asn Thr Arg Val Asn Val Asp Phe Gln Lys Gln Thr Val Asp 
865                 870                 875                 880 


Pro Met Gln Val Ser Phe Asn Thr Ser Asp Arg Ser Gln Thr Val Thr 
                885                 890                 895     


Asp Leu Leu Leu Thr Ile Asp Val Thr Glu Val Val Glu Val Gly His 
            900                 905                 910         


Phe Trp Gly Tyr Arg Ile Asp Glu Asn Asn Ser Glu Ile Leu Lys Lys 
        915                 920                 925             


Leu Thr Ala Glu Ile Asn Gln Leu Thr Leu Val Pro Leu Pro Thr His 
    930                 935                 940                 


Pro His Pro Asp Leu Val Cys Leu Ala Pro Phe Ala Asp Phe Asp Lys 
945                 950                 955                 960 


Gln Arg Tyr Phe Arg Ala Gln Val Leu Tyr Val Ser Gly Asn Ser Ala 
                965                 970                 975     


Glu Val Phe Phe Val Asp Tyr Gly Asn Lys Ser His Val Asp Leu His 
            980                 985                 990         


Leu Leu Met Glu Ile Pro Cys Gln  Phe Leu Glu Leu Pro  Phe Gln Ala 
        995                 1000                 1005             


Leu Glu  Phe Lys Ile Cys Lys  Met Arg Pro Ser Ala  Lys Ser Leu 
    1010                 1015                 1020             


Val Cys  Gly Lys His Trp Ser  Asp Gly Ala Ser Gln  Trp Phe Ala 
    1025                 1030                 1035             


Ser Leu  Val Ser Gly Cys Thr  Leu Leu Val Lys Val  Phe Ser Val 
    1040                 1045                 1050             


Val His  Ser Val Leu His Val  Asp Val Tyr Gln Tyr  Ser Gly Val 
    1055                 1060                 1065             


Gln Asp  Ala Ile Asn Ile Arg  Asp Val Leu Ile Gln  Gln Gly Tyr 
    1070                 1075                 1080             


Ala Glu  Leu Thr Glu Glu Ser  Tyr Glu Ser Lys Gln  Ser His Glu 
    1085                 1090                 1095             


Val Leu  Lys Gly Leu Phe Ser  Lys Ser Val Glu Asn  Met Thr Asp 
    1100                 1105                 1110             


Gly Ser  Val Pro Phe Pro Met  Lys Asp Asp Glu Lys  Tyr Leu Ile 
    1115                 1120                 1125             


Arg Ile  Leu Leu Glu Ser Phe  Ser Thr Asn Lys Leu  Gly Thr Pro 
    1130                 1135                 1140             


Asn Cys  Lys Ala Glu Leu His  Gly Pro Phe Asn Pro  Tyr Glu Leu 
    1145                 1150                 1155             


Lys Cys  His Ser Leu Thr Arg  Ile Ser Lys Phe Arg  Cys Val Trp 
    1160                 1165                 1170             


Ile Glu  Lys Glu Ser Ile Asn  Ser Val Ile Ile Ser  Asp Ala Pro 
    1175                 1180                 1185             


Glu Asp  Leu His Gln Arg Met  Leu Val Ala Ala Ser  Leu Ser Ile 
    1190                 1195                 1200             


Asn Ala  Thr Gly Ser Thr Met  Leu Leu Arg Glu Thr  Ser Leu Met 
    1205                 1210                 1215             


Pro His  Ile Pro Gly Leu Pro  Ala Leu Leu Ser Met  Leu Phe Ala 
    1220                 1225                 1230             


Pro Val  Ile Glu Leu Arg Ile  Asp Gln Asn Gly Lys  Tyr Tyr Thr 
    1235                 1240                 1245             


Gly Val  Leu Cys Gly Leu Gly  Trp Asn Pro Ala Thr  Gly Ala Ser 
    1250                 1255                 1260             


Ile Leu  Pro Glu His Asp Met  Glu Leu Ala Phe Asp  Val Gln Phe 
    1265                 1270                 1275             


Ser Val  Glu Asp Val Val Glu  Val Asn Ile Leu Arg  Ala Ala Ile 
    1280                 1285                 1290             


Asn Lys  Leu Val Cys Asp Gly  Pro Asn Gly Cys Lys  Cys Leu Gly 
    1295                 1300                 1305             


Pro Glu  Arg Val Ala Gln Leu  Gln Asp Ile Ala Arg  Gln Lys Leu 
    1310                 1315                 1320             


Leu Gly  Leu Phe Cys Gln Ser  Lys Pro Arg Glu Lys  Ile Val Pro 
    1325                 1330                 1335             


Lys Trp  His Glu Lys Pro Tyr  Glu Trp Asn Gln Val  Asp Pro Lys 
    1340                 1345                 1350             


Leu Val  Met Glu Gln Ala Asp  Arg Glu Ser Ser Arg  Gly Lys Asn 
    1355                 1360                 1365             


Thr Phe  Leu Tyr Gln Leu His  Lys Leu Val Val Leu  Gly Thr 
    1370                 1375                 1380         


<210> 7200
<211> 118
<212> PRT
<213> Homo sapiens

<400> 7200
Met Asp Val Phe Leu Met Ile Arg Arg His Lys Thr Thr Ile Phe Thr 
1               5                   10                  15      


Asp Ala Lys Glu Ser Ser Thr Val Phe Glu Leu Lys Arg Ile Val Glu 
            20                  25                  30          


Gly Ile Leu Lys Arg Pro Pro Asp Glu Gln Arg Leu Tyr Lys Asp Asp 
        35                  40                  45              


Gln Leu Leu Asp Asp Gly Lys Thr Leu Gly Glu Cys Gly Phe Thr Ser 
    50                  55                  60                  


Gln Thr Ala Arg Pro Gln Ala Pro Ala Thr Val Gly Leu Ala Phe Arg 
65                  70                  75                  80  


Ala Asp Asp Thr Phe Glu Ala Leu Cys Ile Glu Pro Phe Ser Ser Pro 
                85                  90                  95      


Pro Glu Leu Pro Asp Val Met Lys Pro Gln Asp Ser Gly Ser Ser Ala 
            100                 105                 110         


Asn Glu Gln Ala Val Gln 
        115             


<210> 7201
<211> 1075
<212> PRT
<213> Homo sapiens

<400> 7201
Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Cys Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Ser Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Ser Leu Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu 
    370                 375                 380                 


Glu Glu Ser Gln Arg Phe Lys Gly Ser Glu Asn Ser Gln Pro Glu Lys 
385                 390                 395                 400 


Met Ser Gln Glu Pro Glu Ile Asn Lys Asp Gly Asp Arg Glu Val Glu 
                405                 410                 415     


Glu Glu Met Lys Lys His Glu Ser Asn Asn Val Gly Leu Leu Glu Asn 
            420                 425                 430         


Leu Thr Asn Gly Val Thr Ala Gly Asn Gly Asp Asn Gly Leu Ile Pro 
        435                 440                 445             


Gln Arg Lys Ser Arg Thr Pro Glu Asn Gln Gln Phe Pro Asp Asn Glu 
    450                 455                 460                 


Ser Glu Glu Tyr His Arg Ile Cys Glu Leu Leu Ser Asp Tyr Lys Glu 
465                 470                 475                 480 


Lys Gln Met Pro Lys Tyr Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp 
                485                 490                 495     


Leu Lys Leu Thr Ser Glu Glu Glu Ser Gln Arg Leu Lys Gly Ser Glu 
            500                 505                 510         


Asn Gly Gln Pro Glu Lys Arg Ser Gln Glu Pro Glu Ile Asn Lys Asp 
        515                 520                 525             


Gly Asp Arg Glu Leu Glu Asn Phe Met Ala Ile Glu Glu Met Lys Lys 
    530                 535                 540                 


His Arg Ser Thr His Val Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala 
545                 550                 555                 560 


Thr Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg 
                565                 570                 575     


Thr Pro Glu Ser Gln Gln Phe Pro Asp Thr Glu Asn Glu Glu Tyr His 
            580                 585                 590         


Ser Asp Glu Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn 
        595                 600                 605             


Thr Gly Ile Leu His Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile 
    610                 615                 620                 


Glu Val Val Glu Lys Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys 
625                 630                 635                 640 


Glu Lys Asp Ile Leu His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala 
                645                 650                 655     


Met Leu Arg Leu Glu Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg 
            660                 665                 670         


Glu Lys Lys Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys Arg Asn Asp 
        675                 680                 685             


Asn Leu Leu Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp 
    690                 695                 700                 


Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly 
705                 710                 715                 720 


Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly 
                725                 730                 735     


Arg Pro Arg Gln Gln Gly Met Met Gly Gly Met His Gln Lys Glu Ser 
            740                 745                 750         


Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys 
        755                 760                 765             


Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys 
    770                 775                 780                 


Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu 
785                 790                 795                 800 


His Pro Val Leu Leu Thr Glu Ala Thr Leu Asn Pro Lys Ala Asn Arg 
                805                 810                 815     


Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met 
            820                 825                 830         


Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Thr Ser Gly Arg Thr 
        835                 840                 845             


Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro 
    850                 855                 860                 


Ile Tyr Glu Gly Asn Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu 
865                 870                 875                 880 


Ala Gly Arg Glu Leu Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu His 
                885                 890                 895     


Gly Tyr Arg Phe Thr Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile 
            900                 905                 910         


Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala 
        915                 920                 925             


Thr Val Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp 
    930                 935                 940                 


Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala 
945                 950                 955                 960 


Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu 
                965                 970                 975     


Thr Thr Phe Asn Ser Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp 
            980                 985                 990         


Leu Tyr Thr Asn Thr Val Leu Ser  Gly Gly Thr Thr Met  Tyr Pro Gly 
        995                 1000                 1005             


Met Ala  His Arg Met Gln Lys  Glu Ile Ala Ala Leu  Ala Pro Ser 
    1010                 1015                 1020             


Met Met  Lys Ile Arg Ile Ile  Ala Pro Pro Lys Arg  Lys Tyr Ser 
    1025                 1030                 1035             


Val Trp  Val Gly Gly Ser Ile  Leu Ala Ser Leu Ser  Thr Phe Gln 
    1040                 1045                 1050             


Gln Met  Trp Ile Ser Lys Gln  Glu Tyr Asp Glu Ser  Gly Pro Ser 
    1055                 1060                 1065             


Ile Val  His Arg Lys Cys Leu  
    1070                 1075 


<210> 7202
<211> 126
<212> PRT
<213> Homo sapiens

<400> 7202
Met Thr Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala His Lys Thr 
1               5                   10                  15      


Pro Lys Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr Leu Asp Gly 
            20                  25                  30          


Ala Ala Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser Arg Val Ser 
        35                  40                  45              


Ile Lys Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys Arg Arg Ile 
    50                  55                  60                  


Tyr Arg Ile Phe Ser His Ala Tyr Phe His His Arg Gln Ile Phe Asp 
65                  70                  75                  80  


Glu Tyr Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr Lys Phe Val 
                85                  90                  95      


Met Lys Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val Pro Ile Leu 
            100                 105                 110         


Glu Glu Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu Ala 
        115                 120                 125     


<210> 7203
<211> 936
<212> PRT
<213> Homo sapiens

<400> 7203
Met Glu Pro Asp Ile Ile Arg Met Tyr Ser Ser Ser Pro Pro Pro Leu 
1               5                   10                  15      


Asp Asn Gly Ala Glu Asp Asp Asp Asp Asp Glu Phe Gly Glu Phe Gly 
            20                  25                  30          


Gly Phe Ser Glu Val Ser Pro Ser Gly Val Gly Phe Val Asp Phe Asp 
        35                  40                  45              


Thr Pro Asp Tyr Thr Arg Pro Lys Glu Glu Phe Val Pro Ser Asn His 
    50                  55                  60                  


Phe Met Pro Ile His Glu Phe Ser Glu Asn Val Asp Ser Leu Thr Ser 
65                  70                  75                  80  


Phe Lys Ser Ile Lys Asn Gly Asn Asp Lys Asp Ile Thr Ala Glu Leu 
                85                  90                  95      


Ser Ala Pro Val Lys Gly Gln Ser Asp Val Leu Leu Ser Thr Thr Ser 
            100                 105                 110         


Lys Glu Ile Ile Ser Ser Glu Met Leu Ala Thr Ser Ile Asp Gly Met 
        115                 120                 125             


Glu Arg Pro Gly Asn Leu Asn Lys Val Val Glu Gln Arg Gln Asn Val 
    130                 135                 140                 


Gly Thr Leu Glu Ser Phe Ser Pro Gly Asp Phe Arg Thr Asn Met Asn 
145                 150                 155                 160 


Val Val His Gln Asn Lys Gln Leu Glu Ser Cys Asn Gly Glu Lys Pro 
                165                 170                 175     


Pro Cys Leu Glu Ile Leu Thr Asn Gly Phe Ala Val Leu Glu Thr Val 
            180                 185                 190         


Asn Pro Gln Gly Thr Asp Asp Leu Asp Asn Val Ala Asp Ser Lys Gly 
        195                 200                 205             


Arg Lys Pro Leu Ser Thr His Ser Thr Glu Tyr Asn Leu Asp Ser Val 
    210                 215                 220                 


Pro Ser Pro Ala Glu Glu Phe Ala Asp Phe Ala Thr Phe Ser Lys Lys 
225                 230                 235                 240 


Glu Arg Ile Gln Leu Glu Glu Ile Glu Cys Ala Val Leu Asn Asp Arg 
                245                 250                 255     


Glu Ala Leu Thr Ile Arg Glu Asn Asn Lys Ile Asn Arg Val Asn Glu 
            260                 265                 270         


Leu Asn Ser Val Lys Glu Val Ala Leu Gly Arg Ser Leu Asp Asn Lys 
        275                 280                 285             


Gly Asp Thr Asp Gly Glu Asp Gln Val Cys Val Ser Glu Ile Ser Ile 
    290                 295                 300                 


Val Thr Asn Arg Gly Phe Ser Val Glu Lys Gln Gly Leu Pro Thr Leu 
305                 310                 315                 320 


Gln Gln Asp Glu Phe Leu Gln Ser Gly Val Gln Ser Lys Ala Trp Ser 
                325                 330                 335     


Leu Val Asp Ser Ala Asp Asn Ser Glu Ala Ile Arg Arg Glu Gln Cys 
            340                 345                 350         


Lys Thr Glu Glu Lys Leu Asp Leu Leu Thr Ser Lys Cys Ala His Leu 
        355                 360                 365             


Cys Met Asp Ser Val Lys Thr Ser Asp Asp Glu Val Gly Ser Pro Lys 
    370                 375                 380                 


Glu Glu Ser Arg Lys Phe Thr Asn Phe Gln Ser Pro Asn Ile Asp Pro 
385                 390                 395                 400 


Thr Glu Glu Asn Asp Leu Asp Asp Ser Leu Ser Val Lys Asn Gly Asp 
                405                 410                 415     


Ser Ser Asn Asp Phe Val Thr Cys Asn Asp Ile Asn Glu Asp Asp Phe 
            420                 425                 430         


Gly Asp Phe Gly Asp Phe Gly Ser Ala Ser Gly Ser Thr Pro Pro Phe 
        435                 440                 445             


Val Thr Gly Thr Gln Asp Ser Met Ser Asp Ala Thr Phe Glu Glu Ser 
    450                 455                 460                 


Ser Glu His Phe Pro His Phe Ser Glu Pro Gly Asp Asp Phe Gly Glu 
465                 470                 475                 480 


Phe Gly Asp Ile Asn Ala Val Ser Cys Gln Glu Glu Thr Ile Leu Thr 
                485                 490                 495     


Lys Ser Asp Leu Lys Gln Thr Ser Asp Asn Leu Ser Glu Glu Cys Gln 
            500                 505                 510         


Leu Ala Arg Lys Ser Ser Gly Thr Gly Thr Glu Pro Val Ala Lys Leu 
        515                 520                 525             


Lys Asn Gly Gln Glu Gly Glu Ile Gly His Phe Asp Ser Val Pro Asn 
    530                 535                 540                 


Ile Gln Asp Asp Cys Asn Gly Phe Gln Asp Ser Asp Asp Phe Ala Asp 
545                 550                 555                 560 


Phe Ser Ser Ala Gly Pro Ser Gln Val Val Asp Trp Asn Ala Phe Glu 
                565                 570                 575     


Asp Glu Gln Lys Asp Ser Cys Ser Trp Ala Ala Phe Gly Asp Gln Gln 
            580                 585                 590         


Ala Thr Glu Ser His His Arg Lys Glu Ala Trp Gln Ser His Arg Thr 
        595                 600                 605             


Asp Glu Asn Ile Asp Thr Pro Gly Thr Pro Lys Thr His Ser Val Pro 
    610                 615                 620                 


Ser Ala Thr Ser Lys Gly Ala Val Ala Ser Gly His Leu Gln Glu Ser 
625                 630                 635                 640 


Ala Thr Ser Val Gln Thr Ala Leu Leu Asn Arg Leu Glu Arg Ile Phe 
                645                 650                 655     


Glu Ala Cys Phe Pro Ser Ile Leu Val Pro Asp Ala Glu Glu Glu Val 
            660                 665                 670         


Thr Ser Leu Lys His Leu Leu Glu Thr Ser Thr Leu Pro Ile Lys Thr 
        675                 680                 685             


Arg Glu Ala Leu Pro Glu Ser Gly Glu Leu Leu Asp Val Trp Thr Glu 
    690                 695                 700                 


Leu Gln Asp Ile His Asp Ala His Gly Leu Arg Tyr Gln Trp Gly Gly 
705                 710                 715                 720 


Ser His Ser Asn Lys Lys Leu Leu Ser Ser Leu Gly Ile Asp Thr Arg 
                725                 730                 735     


Asn Ile Leu Phe Thr Gly Asn Lys Lys Gln Pro Val Ile Val Pro Met 
            740                 745                 750         


Tyr Ala Ala Gly Leu Gly Met Leu Glu Pro Thr Lys Glu Pro Leu Lys 
        755                 760                 765             


Pro Leu Ser Ala Ala Glu Lys Ile Ala Ser Ile Gly Gln Thr Ala Thr 
    770                 775                 780                 


Met Ser Pro Asp Met Asn Thr Cys Thr Ser Asp Gln Phe Gln Glu Ser 
785                 790                 795                 800 


Leu Pro Pro Val Gln Phe Asp Trp Ser Ser Ser Gly Leu Thr Asn Pro 
                805                 810                 815     


Leu Asp Ala Ser Gly Gly Ser Thr Leu Leu Asn Leu Asp Phe Phe Gly 
            820                 825                 830         


Pro Val Asp Asp Ser Ser Ser Ser Ser Ser Thr Thr Ile Pro Gly Val 
        835                 840                 845             


Asp Pro Glu Leu Tyr Glu Leu Thr Thr Ser Lys Leu Glu Ile Ser Thr 
    850                 855                 860                 


Ser Ser Leu Lys Val Thr Asp Ala Phe Ala Arg Leu Met Ser Thr Val 
865                 870                 875                 880 


Glu Lys Thr Ser Thr Ser Thr Arg Lys Pro Lys Arg Glu Glu His Leu 
                885                 890                 895     


Ser Glu Glu Ala Ile Lys Val Ile Ala Gly Leu Pro Asp Leu Thr Phe 
            900                 905                 910         


Met His Ala Lys Val Leu Met Phe Pro Ala Thr Leu Thr Pro Ser Thr 
        915                 920                 925             


Ser Ser Gln Glu Lys Ala Asp Gly 
    930                 935     


<210> 7204
<211> 619
<212> PRT
<213> Homo sapiens

<400> 7204
Met Asp Asp Gln Gln Ala Leu Asn Ser Ile Met Gln Asp Leu Ala Val 
1               5                   10                  15      


Leu His Lys Ala Ser Arg Pro Ala Leu Ser Leu Gln Glu Thr Arg Lys 
            20                  25                  30          


Ala Lys Ser Ser Ser Pro Lys Lys Gln Asn Asp Val Arg Val Lys Phe 
        35                  40                  45              


Glu His Arg Gly Glu Lys Arg Ile Leu Gln Phe Pro Arg Pro Val Lys 
    50                  55                  60                  


Leu Glu Asp Leu Arg Ser Lys Ala Lys Ile Ala Phe Gly Gln Ser Met 
65                  70                  75                  80  


Asp Leu His Tyr Thr Asn Asn Glu Leu Val Ile Pro Leu Thr Thr Gln 
                85                  90                  95      


Asp Asp Leu Asp Lys Ala Val Glu Leu Leu Asp Arg Ser Ile His Met 
            100                 105                 110         


Lys Ser Leu Lys Ile Leu Leu Val Ile Asn Gly Ser Thr Gln Ala Thr 
        115                 120                 125             


Asn Leu Glu Pro Leu Pro Ser Leu Glu Asp Leu Asp Asn Thr Val Phe 
    130                 135                 140                 


Gly Ala Glu Arg Lys Lys Arg Leu Ser Ile Ile Gly Pro Thr Ser Arg 
145                 150                 155                 160 


Asp Arg Ser Ser Pro Pro Pro Gly Tyr Ile Pro Asp Glu Leu His Gln 
                165                 170                 175     


Val Ala Arg Asn Gly Ser Phe Thr Ser Ile Asn Ser Glu Gly Glu Phe 
            180                 185                 190         


Ile Pro Glu Ser Met Asp Gln Met Leu Asp Pro Leu Ser Leu Ser Ser 
        195                 200                 205             


Pro Glu Asn Ser Gly Ser Gly Ser Cys Pro Ser Leu Asp Ser Pro Leu 
    210                 215                 220                 


Asp Gly Glu Ser Tyr Pro Lys Ser Arg Met Pro Arg Ala Gln Ser Tyr 
225                 230                 235                 240 


Pro Asp Asn His Gln Glu Phe Ser Asp Tyr Asp Asn Pro Ile Phe Glu 
                245                 250                 255     


Lys Phe Gly Lys Gly Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Tyr 
            260                 265                 270         


His His Gln Glu Tyr Asn Asp Gly Arg Lys Thr Phe Pro Arg Ala Arg 
        275                 280                 285             


Arg Thr Gln Gly Thr Ser Leu Arg Ser Pro Val Ser Phe Ser Pro Thr 
    290                 295                 300                 


Asp His Ser Leu Ser Thr Ser Ser Gly Ser Ser Ile Phe Thr Pro Glu 
305                 310                 315                 320 


Tyr Asp Asp Ser Arg Ile Arg Arg Arg Gly Ser Asp Ile Asp Asn Pro 
                325                 330                 335     


Thr Leu Thr Val Met Asp Ile Ser Pro Pro Ser Arg Ser Pro Arg Ala 
            340                 345                 350         


Pro Thr Asn Trp Arg Leu Gly Lys Leu Leu Gly Gln Gly Ala Phe Gly 
        355                 360                 365             


Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr Gly Arg Glu Leu Ala Val 
    370                 375                 380                 


Lys Gln Val Gln Phe Asp Pro Asp Ser Pro Glu Thr Ser Lys Glu Val 
385                 390                 395                 400 


Asn Ala Leu Glu Cys Glu Ile Gln Leu Leu Lys Asn Leu Leu His Glu 
                405                 410                 415     


Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg Asp Pro Gln Glu Lys Thr 
            420                 425                 430         


Leu Ser Ile Phe Met Glu Tyr Met Pro Gly Gly Ser Ile Lys Asp Gln 
        435                 440                 445             


Leu Lys Ala Tyr Gly Ala Leu Thr Glu Asn Val Thr Arg Lys Tyr Thr 
    450                 455                 460                 


Arg Gln Ile Leu Glu Gly Val His Tyr Leu His Ser Asn Met Ile Val 
465                 470                 475                 480 


His Arg Asp Ile Lys Gly Ala Asn Ile Leu Arg Asp Ser Thr Gly Asn 
                485                 490                 495     


Val Lys Leu Gly Asp Phe Gly Ala Ser Lys Arg Leu Gln Thr Ile Cys 
            500                 505                 510         


Leu Ser Gly Thr Gly Met Lys Ser Val Thr Gly Thr Pro Tyr Trp Met 
        515                 520                 525             


Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr Gly Arg Lys Ala Asp Ile 
    530                 535                 540                 


Trp Ser Val Ala Cys Thr Val Val Glu Met Leu Thr Glu Lys Pro Pro 
545                 550                 555                 560 


Trp Ala Glu Phe Glu Ala Met Ala Ala Ile Phe Lys Ile Ala Thr Gln 
                565                 570                 575     


Pro Thr Asn Pro Lys Leu Pro Pro His Val Ser Asp Tyr Thr Arg Asp 
            580                 585                 590         


Phe Leu Lys Arg Ile Phe Val Glu Ala Lys Leu Arg Pro Ser Ala Asp 
        595                 600                 605             


Glu Leu Leu Arg His Met Phe Val His Tyr His 
    610                 615                 


<210> 7205
<211> 170
<212> PRT
<213> Homo sapiens

<400> 7205
Met Thr Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Gln Ser Asp Ser Val Lys Gly Lys Arg Arg Asp Asp Gly Leu Ser 
            20                  25                  30          


Ala Ala Ala Arg Lys Gln Arg Val Gly Val Gln Gln Pro Asn Ala Glu 
        35                  40                  45              


Leu Ser Pro Ile His Phe His Leu Ile Leu Cys Ala Leu His Pro Pro 
    50                  55                  60                  


Ala Ser Cys Pro Phe Cys Pro Leu Val Pro Pro Ser Ala Pro Ser Ser 
65                  70                  75                  80  


Leu Pro Pro Gly Thr Arg Arg Ser Cys Ser Arg Ser Arg Lys Arg Gln 
                85                  90                  95      


Thr Arg Arg Arg Arg Asn Pro Ser Ser Phe Val Ala Ser Cys Pro Thr 
            100                 105                 110         


Leu Leu Pro Phe Ala Cys Val Pro Gly Ala Ser Pro Thr Thr Leu Ala 
        115                 120                 125             


Phe Pro Pro Val Val Leu Thr Gly Pro Ser Thr Asp Gly Ile Pro Phe 
    130                 135                 140                 


Ala Leu Ser Leu Gln Arg Val Pro Phe Val Leu Pro Ser Pro Gln Val 
145                 150                 155                 160 


Ala Ser Leu Pro Leu Gly His Ser Arg Gly 
                165                 170 


<210> 7206
<211> 209
<212> PRT
<213> Homo sapiens

<400> 7206
Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val 
1               5                   10                  15      


Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg 
            20                  25                  30          


Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp 
        35                  40                  45              


Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val 
    50                  55                  60                  


Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe 
65                  70                  75                  80  


Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu 
                85                  90                  95      


Phe Glu Leu Thr Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu 
            100                 105                 110         


Ser Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro 
        115                 120                 125             


Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr 
    130                 135                 140                 


Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser 
145                 150                 155                 160 


Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile 
                165                 170                 175     


Asp Ile Ile Ala Glu Leu Arg Tyr Asp Leu Pro Ala Ser Tyr Lys Phe 
            180                 185                 190         


His Lys Lys Lys Ser Val Asp Ile Glu Val Asp Leu Ile Arg Phe Ser 
        195                 200                 205             


Phe 
    


<210> 7207
<211> 584
<212> PRT
<213> Homo sapiens

<400> 7207
Met Ala Ala Ser Ala Lys Arg Lys Gln Glu Glu Lys His Leu Lys Met 
1               5                   10                  15      


Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp Cys 
            20                  25                  30          


Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe Val 
        35                  40                  45              


Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His Arg 
    50                  55                  60                  


Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu Phe 
65                  70                  75                  80  


Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly Leu 
                85                  90                  95      


Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln Lys 
            100                 105                 110         


Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr Val 
        115                 120                 125             


Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile Ser 
    130                 135                 140                 


Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro Leu 
145                 150                 155                 160 


Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys Gly 
                165                 170                 175     


Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln Gln 
            180                 185                 190         


Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile Phe 
        195                 200                 205             


Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn Phe 
    210                 215                 220                 


Ala His Phe Asn Ser His Ala Ala Gln Asn Ser Ala Asn Ala Asp Phe 
225                 230                 235                 240 


Ala Asn Phe Asp Ala Phe Gly Gln Ser Ser Gly Ser Ser Asn Phe Gly 
                245                 250                 255     


Gly Phe Pro Thr Ala Ser His Ser Pro Phe Gln Pro Gln Thr Thr Ala 
            260                 265                 270         


Phe Arg Met Leu Ser Ser Ser Cys Ser Phe Gly Glu Phe Thr Ser Ala 
        275                 280                 285             


Phe Pro Leu Gln Ala Thr His Ser Gly Ser Ala Ala Ser Val Asn Ala 
    290                 295                 300                 


Asn Phe Ala His Phe Asp Asn Phe Pro Lys Ser Ser Ser Ala Asp Phe 
305                 310                 315                 320 


Gly Thr Phe Asn Thr Ser Gln Ser His Gln Thr Ala Ser Ala Val Ser 
                325                 330                 335     


Lys Val Ser Thr Asn Lys Ala Gly Leu Gln Thr Ala Asp Lys Tyr Ala 
            340                 345                 350         


Ala Leu Ala Asn Leu Asp Asn Ile Phe Ser Ala Gly Gln Gly Gly Asp 
        355                 360                 365             


Gln Gly Ser Gly Phe Gly Thr Thr Gly Lys Ala Pro Val Gly Ser Val 
    370                 375                 380                 


Val Ser Val Pro Ser Gln Ser Ser Ala Ser Ser Asp Lys Tyr Ala Ala 
385                 390                 395                 400 


Leu Ala Glu Leu Asp Ser Val Phe Ser Ser Ala Ala Thr Ser Ser Asn 
                405                 410                 415     


Ala Tyr Thr Ser Thr Ser Asn Ala Ser Ser Asn Val Phe Gly Thr Val 
            420                 425                 430         


Pro Val Val Ala Ser Ala Gln Thr Gln Pro Ala Ser Ser Ser Val Pro 
        435                 440                 445             


Ala Pro Phe Gly Ala Thr Pro Ser Thr Asn Pro Phe Val Ala Ala Ala 
    450                 455                 460                 


Gly Pro Ser Val Ala Ser Ser Thr Asn Pro Phe Gln Thr Asn Ala Arg 
465                 470                 475                 480 


Gly Ala Thr Ala Ala Thr Phe Gly Thr Ala Ser Met Ser Met Pro Thr 
                485                 490                 495     


Gly Phe Gly Thr Pro Ala Pro Tyr Ser Leu Pro Thr Ser Phe Ser Gly 
            500                 505                 510         


Ser Phe Gln Gln Pro Ala Phe Pro Ala Gln Ala Ala Phe Pro Gln Gln 
        515                 520                 525             


Thr Ala Phe Ser Gln Gln Pro Asn Gly Phe Ala Ala Phe Gly Gln Thr 
    530                 535                 540                 


Lys Pro Val Val Thr Pro Phe Gly Gln Val Ala Ala Ala Gly Val Ser 
545                 550                 555                 560 


Ser Asn Pro Phe Met Thr Gly Ala Pro Thr Gly Gln Phe Pro Thr Gly 
                565                 570                 575     


Ser Ser Ser Thr Asn Pro Phe Leu 
            580                 


<210> 7208
<211> 264
<212> PRT
<213> Homo sapiens

<400> 7208
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Thr Ser Gly Ser Ala Leu Thr Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu 
    50                  55                  60                  


Gln Leu Leu Asn Leu Phe Ala Tyr Gly Thr Tyr Pro Asp Tyr Ile Ala 
65                  70                  75                  80  


Asn Lys Glu Ser Leu Pro Glu Leu Ser Thr Ala Gln Gln Asn Lys Leu 
                85                  90                  95      


Lys His Leu Thr Ile Val Ser Leu Ala Ser Arg Met Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg Asn Leu Arg Glu Leu 
        115                 120                 125             


Glu Asp Leu Ile Ile Glu Ala Val Tyr Thr Asp Ile Ile Gln Gly Lys 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp Phe Cys Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val Lys Thr Leu His Glu 
                165                 170                 175     


Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly Ile Glu Gln Gln Val 
            180                 185                 190         


Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn Arg Thr Gln Gln Gln 
        195                 200                 205             


Val Glu Ala Glu Val Thr Asn Ile Lys Lys Thr Leu Lys Ala Thr Ala 
    210                 215                 220                 


Ser Ser Ser Ala Gln Glu Met Glu Gln Gln Leu Ala Glu Arg Glu Cys 
225                 230                 235                 240 


Pro Pro His Ala Glu Gln Arg Gln Pro Thr Lys Lys Met Ser Lys Val 
                245                 250                 255     


Lys Gly Leu Val Ser Ser Arg His 
            260                 


<210> 7209
<211> 501
<212> PRT
<213> Homo sapiens

<400> 7209
Met Ser Ser Glu Gln Asp Lys Ser Ala Ser Lys Glu Lys Ser Lys Lys 
1               5                   10                  15      


Pro Val Arg Phe Leu Pro Gln Leu Ser Met Glu Lys Leu Ala Ser Lys 
            20                  25                  30          


Glu Lys Phe Lys Ala Pro Ala Arg Ala Leu Pro Gln Leu Ser Met Val 
        35                  40                  45              


Ser Thr Lys Pro His Trp Gln Gln Ala Ala Pro Ser Phe His Leu Ser 
    50                  55                  60                  


Val Lys Gln Asp Asp Glu Ser Pro Glu Pro Phe Ser Val Lys Asn Glu 
65                  70                  75                  80  


Gln Ser His Ala Glu Tyr Met Glu Arg Phe Gly Lys Lys Gly Lys Leu 
                85                  90                  95      


Pro His Gln Val Asp Asp Ser Tyr Val Gly Pro Ser Thr Ser Lys Ser 
            100                 105                 110         


Lys Gly Lys Ser Pro His Lys Glu Arg Glu Asn Phe Arg Ser Thr Leu 
        115                 120                 125             


Val Asn Val Ile Met Gln Gln Asp Ala Asp Leu Asp Ser Ala Val Pro 
    130                 135                 140                 


Asp Gly Ser Thr Ile Pro Lys Pro Thr Ala Ser Ala Ile Glu Lys Asp 
145                 150                 155                 160 


Ile Leu Arg Tyr Tyr Tyr Tyr Ile His His Gly Ile Asp Thr Asp His 
                165                 170                 175     


Val Ala Pro Met Glu Asp Ser Trp Leu Glu His Val Leu Asp Leu Val 
            180                 185                 190         


Pro Gln His Leu Lys Val Phe Thr Asp Ser Ile Val Thr Leu Ser Asp 
        195                 200                 205             


Glu Met Arg Glu Asp Tyr Leu Leu Ser Val Arg Lys Ser Ile Val Asp 
    210                 215                 220                 


Phe Val Leu Lys Asp Pro Arg Glu Lys Gly Asp Asp Lys Lys Thr Asp 
225                 230                 235                 240 


Glu Leu Pro Ala His Arg Ala Glu Met Glu Ile Leu Pro Lys Pro Trp 
                245                 250                 255     


Arg Lys Ser Phe Leu Ala Ala Ser Ser Tyr Ile Arg Asp His Leu Asn 
            260                 265                 270         


Ala Met Asn Pro Thr Met Leu Ala Val Leu Asp Leu Trp His Thr Asn 
        275                 280                 285             


Phe Lys Lys Leu Arg Leu Val Asp Ile Lys Glu Phe His Asn Cys Gln 
    290                 295                 300                 


Asp Ala Leu Glu Leu Ser Ser Phe Gln Asn Ile Ile Met Arg His Met 
305                 310                 315                 320 


Asp Ser Ala Lys Glu Thr Leu Leu Lys Met Trp Phe Pro Glu Val Gln 
                325                 330                 335     


Asn Ile Tyr Tyr Gln Gly Asn Lys Lys Lys Gln Leu Pro Thr Gly Asp 
            340                 345                 350         


Ser Ser Ala Lys Leu Glu Ser Phe Phe Asn Cys Ala Ala Ala Leu Met 
        355                 360                 365             


Thr Leu Gln Leu Gln Asp Leu Thr Leu Val Ser Met Gln Asp Phe Thr 
    370                 375                 380                 


Asp Leu Ile Ala Gln Pro Pro Asp Ser Val Arg Ala Phe Glu His Pro 
385                 390                 395                 400 


Gly Phe Ile Met Arg Leu Ile Leu Asp Asn Asp Thr Ile Lys Phe Glu 
                405                 410                 415     


Pro Glu Leu Ser Asp Tyr Ile Asp Ile Phe Leu Asn Val Tyr Asp Val 
            420                 425                 430         


Met Ile Lys Ala Val Ser Phe Val Pro Arg Val Glu Thr Lys Leu Tyr 
        435                 440                 445             


Ser Lys Trp Arg Asn Lys Ala Lys Pro Gly His Phe Tyr Phe Ser His 
    450                 455                 460                 


Ile Gln Arg Ser Val Thr Phe Gln His Ser Glu Val Ser Ser Pro Gln 
465                 470                 475                 480 


Asn Ser His Phe Lys Ile Val Ser Pro Phe Ser Val Leu Gly Phe Thr 
                485                 490                 495     


Trp Arg Cys Gln Leu 
            500     


<210> 7210
<211> 284
<212> PRT
<213> Homo sapiens

<400> 7210
Met Thr Asp Val Pro Ala Thr Phe Thr Gln Ala Glu Cys Asn Gly Asp 
1               5                   10                  15      


Lys Pro Pro Glu Asn Gly Gln Gln Thr Ile Thr Lys Ile Ser Glu Glu 
            20                  25                  30          


Leu Thr Asp Val Asp Ser Pro Leu Pro His Tyr Arg Val Glu Pro Ser 
        35                  40                  45              


Leu Glu Gly Ala Leu Thr Lys Gly Ser Gln Glu Glu Arg Arg Lys Leu 
    50                  55                  60                  


Gln Gly Asn Met Leu Leu Asn Ser Ser Met Glu Asp Lys Met Leu Lys 
65                  70                  75                  80  


Glu Asn Pro Glu Glu Lys Leu Phe Ile Val His Lys Ala Ile Thr Asp 
                85                  90                  95      


Leu Ser Leu Gln Glu Thr Ser Ala Asp Glu Met Thr Phe Arg Glu Gly 
            100                 105                 110         


His Gln Trp Glu Lys Ile Pro Leu Ser Gly Ser Asn Gln Glu Ile Arg 
        115                 120                 125             


Arg Gln Lys Glu Arg Ile Thr Glu Gln Pro Leu Lys Glu Glu Glu Asp 
    130                 135                 140                 


Glu Asp Arg Lys Asn Lys Gly His Gln Ala Ala Glu Ile Glu Trp Leu 
145                 150                 155                 160 


Gly Phe Arg Lys Pro Ser Gln Ala Asp Met Leu His Ser Lys His Asp 
                165                 170                 175     


Glu Glu Gln Lys Val Trp Asp Glu Glu Ile Asp Asp Asp Asp Asp Asp 
            180                 185                 190         


Asn Cys Asn Asn Asp Glu Asp Glu Val Arg Val Ile Glu Phe Lys Lys 
        195                 200                 205             


Lys His Glu Glu Val Ser Gln Phe Lys Glu Glu Gly Asp Ala Ser Glu 
    210                 215                 220                 


Asp Ser Pro Leu Ser Ser Ala Ser Ser Gln Ala Val Thr Pro Asp Glu 
225                 230                 235                 240 


Gln Pro Thr Leu Gly Lys Lys Ser Asp Ile Ser Arg Asn Ala Tyr Ser 
                245                 250                 255     


Arg Tyr Asn Thr Ile Ser Tyr Arg Lys Ile Arg Lys Gly Asn Thr Lys 
            260                 265                 270         


Gln Arg Ile Asp Glu Phe Glu Ser Met Met His Leu 
        275                 280                 


<210> 7211
<211> 244
<212> PRT
<213> Homo sapiens

<400> 7211
Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val 
1               5                   10                  15      


Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg 
            20                  25                  30          


Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp 
        35                  40                  45              


Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val 
    50                  55                  60                  


Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe 
65                  70                  75                  80  


Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu 
                85                  90                  95      


Phe Glu Leu Thr Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu 
            100                 105                 110         


Ser Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro 
        115                 120                 125             


Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr 
    130                 135                 140                 


Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser 
145                 150                 155                 160 


Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile 
                165                 170                 175     


Asp Ile Ile Ala Glu Leu Arg Tyr Asp Leu Pro Ala Ser Tyr Lys Phe 
            180                 185                 190         


His Lys Lys Lys Ser Val Ser Leu Leu Ile Leu Ala Gly Leu His Ser 
        195                 200                 205             


Val Leu Lys Ser Phe Leu Gly Arg Met Trp Trp Phe Met Pro Val Ile 
    210                 215                 220                 


Pro Ala Thr Arg Glu Ala Glu Ala Arg Glu Ser Leu Glu Leu Arg Arg 
225                 230                 235                 240 


Gln Arg Leu Gln 
                


<210> 7212
<211> 294
<212> PRT
<213> Homo sapiens

<400> 7212
Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe 
1               5                   10                  15      


Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe 
            20                  25                  30          


Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu 
        35                  40                  45              


Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg 
    50                  55                  60                  


Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu 
65                  70                  75                  80  


Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys 
                85                  90                  95      


Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln 
            100                 105                 110         


Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe 
        115                 120                 125             


Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu 
    130                 135                 140                 


Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn 
145                 150                 155                 160 


Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu 
                165                 170                 175     


Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser 
            180                 185                 190         


Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys 
        195                 200                 205             


Val Ser Met Asp Asn Arg Leu Met Glu Leu Phe Pro Ala Asn Lys Gln 
    210                 215                 220                 


Ser Val Glu His Phe Thr Lys Tyr Phe Thr Glu Ala Gly Leu Lys Glu 
225                 230                 235                 240 


Leu Ser Glu Tyr Val Arg Asn Gln Gln Thr Ile Gly Ala Arg Lys Glu 
                245                 250                 255     


Leu Gln Lys Glu Leu Gln Glu Gln Met Ser Arg Gly Asp Pro Phe Lys 
            260                 265                 270         


Asp Ile Ile Leu Tyr Val Lys Glu Glu Met Lys Lys Asn Asn Ile Pro 
        275                 280                 285             


Glu Pro Val Val Ile Gly 
    290                 


<210> 7213
<211> 457
<212> PRT
<213> Homo sapiens

<400> 7213
Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Gly Arg Phe Gln Lys Phe 
        435                 440                 445             


Asn Tyr Val Glu Ala Ser Gly Thr Phe 
    450                 455         


<210> 7214
<211> 545
<212> PRT
<213> Homo sapiens

<400> 7214
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 
        35                  40                  45              


Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 
65                  70                  75                  80  


Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 
                85                  90                  95      


Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 
            100                 105                 110         


Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro 
        115                 120                 125             


Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys 
    130                 135                 140                 


Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile 
145                 150                 155                 160 


Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu 
                165                 170                 175     


Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile 
            180                 185                 190         


Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln 
        195                 200                 205             


Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser 
    210                 215                 220                 


Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr 
225                 230                 235                 240 


Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly 
                245                 250                 255     


Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr 
            260                 265                 270         


Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met Arg Lys Lys 
        275                 280                 285             


Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys Gln Arg Glu 
    290                 295                 300                 


Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala Trp Glu Lys 
305                 310                 315                 320 


Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala Lys Glu Ser 
                325                 330                 335     


Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile Arg Lys Gln 
            340                 345                 350         


Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg Gly Ala Gly 
        355                 360                 365             


Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser Glu Ile Ile 
    370                 375                 380                 


Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met Arg Gln Leu 
385                 390                 395                 400 


Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg Arg Val Lys 
                405                 410                 415     


Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys Val Tyr Lys 
            420                 425                 430         


Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys Glu Ile Phe 
        435                 440                 445             


Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu Ile Ala Ser 
    450                 455                 460                 


Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr Tyr Tyr Leu 
465                 470                 475                 480 


Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg Asn Tyr Gly 
                485                 490                 495     


Lys Arg Arg Gly Arg Asn Gln Gln Gln Ile Ala Arg Pro Ser Gln Glu 
            500                 505                 510         


Glu Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr Glu Lys 
        515                 520                 525             


Lys Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys Glu Asp 
    530                 535                 540                 


Ser 
545 


<210> 7215
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7215
Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys Arg Thr 
1               5                   10                  15      


Thr Cys Trp Gln Pro Thr Thr Val Thr Thr Cys Ser Ser Thr Pro Cys 
            20                  25                  30          


Cys Gln Pro Ser Cys Cys Val Ser Ser Cys Cys Gln Pro Cys Cys His 
        35                  40                  45              


Pro Thr Cys Cys Gln Asn Thr Cys Cys Arg Thr Thr Cys Cys Gln Pro 
    50                  55                  60                  


Ile Cys Val Thr Ser Cys Cys Gln Pro Ser Cys Cys Ser Thr Pro Cys 
65                  70                  75                  80  


Cys Gln Pro Thr Cys Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser Cys 
                85                  90                  95      


Ala Pro Val Tyr Cys Arg Arg Thr Cys Tyr His Pro Thr Ser Val Cys 
            100                 105                 110         


Leu Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Asn Cys Cys Gln Pro 
        115                 120                 125             


Cys Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr Cys 
    130                 135                 140                 


Phe Gln Pro Thr Cys Val Tyr Ser Cys Cys Gln Pro Ser Cys Cys 
145                 150                 155                 


<210> 7216
<211> 356
<212> PRT
<213> Homo sapiens

<400> 7216
Met Glu Gly His Asp Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu Phe 
1               5                   10                  15      


Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Asp Ser Leu Arg Glu His 
            20                  25                  30          


Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp Pro 
        35                  40                  45              


Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ser Cys Val 
    50                  55                  60                  


Glu Glu Val Asp Ala Ala Met Cys Ala Arg Pro His Lys Val Asp Gly 
65                  70                  75                  80  


Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Val Lys 
                85                  90                  95      


Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys 
            100                 105                 110         


Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp Tyr Phe Glu Lys Tyr Gly 
        115                 120                 125             


Lys Ile Glu Thr Ile Glu Val Met Glu Asp Arg Gln Ser Gly Lys Lys 
    130                 135                 140                 


Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Thr Val Asp Lys 
145                 150                 155                 160 


Ile Val Val Gln Lys Tyr His Thr Ile Asn Gly His Asn Cys Glu Val 
                165                 170                 175     


Lys Lys Ala Leu Ser Lys Gln Glu Met Gln Ser Ala Gly Ser Gln Arg 
            180                 185                 190         


Gly Arg Gly Gly Gly Ser Gly Asn Phe Met Gly Arg Gly Gly Asn Phe 
        195                 200                 205             


Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly Gly Asn Phe Gly Gly Arg 
    210                 215                 220                 


Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser Arg Gly Ser Tyr Gly Gly 
225                 230                 235                 240 


Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly Asp Gly Gly Asn Tyr Gly 
                245                 250                 255     


Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly Tyr Gly Gly Gly Gly Pro 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Gly Gly Tyr Asp 
        275                 280                 285             


Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly Gly Asn Tyr Gly Gly Gly 
    290                 295                 300                 


Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser Gly Gln Gln Gln Ser Asn 
305                 310                 315                 320 


Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly Gly Arg Ser Ser Gly Ser 
                325                 330                 335     


Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly Gly Ser Gly Gly Tyr Gly 
            340                 345                 350         


Ser Arg Arg Phe 
        355     


<210> 7217
<211> 61
<212> PRT
<213> Homo sapiens

<400> 7217
Met Pro Phe Phe Gly Asn Thr Phe Ser Pro Lys Lys Thr Pro Pro Arg 
1               5                   10                  15      


Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Thr Arg 
            20                  25                  30          


Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Thr Met Asn Leu Ala 
        35                  40                  45              


Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala 
    50                  55                  60      


<210> 7218
<211> 326
<212> PRT
<213> Homo sapiens

<400> 7218
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 
                245                 250                 255     


Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 
            260                 265                 270         


Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 
        275                 280                 285             


Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 
    290                 295                 300                 


Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 
305                 310                 315                 320 


Ala Phe Pro Val Asp Gly 
                325     


<210> 7219
<211> 676
<212> PRT
<213> Homo sapiens

<400> 7219
Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly His Glu 
            260                 265                 270         


His Asp Phe Arg Val Lys His Leu Ser Glu Ala Leu Asn Asp Lys His 
        275                 280                 285             


Gly Pro Leu Ala Gly Arg Asp Asp Met Leu Asp Val Glu Thr Asp Ala 
    290                 295                 300                 


Tyr Ile His Cys Val Ser Ala Phe Val Lys Leu Ala Gln Ser Glu Tyr 
305                 310                 315                 320 


Gln Leu Leu Ala Asp Ile Ile Pro Glu His His Gln Lys Lys Thr Phe 
                325                 330                 335     


Asp Ser Leu Ile Gln Asp Ala Leu Asp Gly Leu Met Leu Glu Gly Glu 
            340                 345                 350         


Asn Ile Val Ser Ala Ala Arg Lys Ala Ile Val Arg His Asp Phe Ser 
        355                 360                 365             


Thr Val Leu Thr Val Phe Pro Ile Leu Arg His Leu Lys Gln Thr Lys 
    370                 375                 380                 


Pro Glu Phe Asp Gln Val Leu Gln Gly Thr Ala Ala Ser Thr Lys Asn 
385                 390                 395                 400 


Lys Leu Pro Gly Leu Ile Thr Ser Met Glu Thr Ile Gly Ala Lys Ala 
                405                 410                 415     


Leu Glu Asp Phe Ala Asp Asn Ile Lys Asn Asp Pro Asp Lys Glu Tyr 
            420                 425                 430         


Asn Met Pro Lys Asp Gly Thr Val His Glu Leu Thr Ser Asn Ala Ile 
        435                 440                 445             


Leu Phe Leu Gln Gln Leu Leu Asp Phe Gln Glu Thr Ala Gly Ala Met 
    450                 455                 460                 


Leu Ala Ser Gln Glu Thr Ser Ser Ser Ala Thr Ser Tyr Ser Ser Glu 
465                 470                 475                 480 


Phe Ser Lys Arg Leu Leu Ser Thr Tyr Ile Cys Lys Val Leu Gly Asn 
                485                 490                 495     


Leu Gln Leu Asn Leu Leu Ser Lys Ser Lys Val Tyr Glu Asp Pro Ala 
            500                 505                 510         


Leu Ser Ala Ile Phe Leu His Asn Asn Tyr Asn Tyr Ile Leu Lys Ser 
        515                 520                 525             


Leu Glu Lys Ser Glu Leu Ile Gln Leu Val Ala Val Thr Gln Lys Thr 
    530                 535                 540                 


Ala Glu Arg Ser Tyr Arg Glu His Ile Glu Gln Gln Ile Gln Thr Tyr 
545                 550                 555                 560 


Gln Arg Ser Trp Leu Lys Val Thr Asp Tyr Ile Ala Glu Lys Asn Leu 
                565                 570                 575     


Pro Val Phe Gln Pro Gly Val Lys Leu Arg Asp Lys Glu Arg Gln Ile 
            580                 585                 590         


Ile Lys Glu Arg Phe Lys Gly Phe Asn Asp Gly Leu Glu Glu Leu Cys 
        595                 600                 605             


Lys Ile Gln Lys Ala Trp Ala Ile Pro Asp Thr Glu Gln Arg Asp Arg 
    610                 615                 620                 


Ile Arg Gln Ala Gln Lys Thr Ile Val Lys Glu Thr Tyr Gly Ala Phe 
625                 630                 635                 640 


Leu Gln Lys Phe Gly Ser Val Pro Phe Thr Lys Asn Pro Glu Lys Tyr 
                645                 650                 655     


Ile Lys Tyr Gly Val Glu Gln Val Gly Asp Met Ile Asp Arg Leu Phe 
            660                 665                 670         


Asp Thr Ser Ala 
        675     


<210> 7220
<211> 152
<212> PRT
<213> Homo sapiens

<400> 7220
Met Thr Asp Val Pro Ala Thr Phe Thr Gln Ala Glu Cys Asn Gly Asp 
1               5                   10                  15      


Lys Pro Pro Glu Asn Gly Gln Gln Thr Ile Thr Lys Ile Ser Glu Glu 
            20                  25                  30          


Leu Thr Asp Val Asp Ser Pro Leu Pro His Tyr Arg Val Glu Pro Ser 
        35                  40                  45              


Leu Glu Gly Ala Leu Thr Lys Gly Ser Gln Glu Glu Arg Arg Lys Leu 
    50                  55                  60                  


Gln Gly Asn Met Leu Leu Asn Ser Ser Met Glu Asp Lys Met Leu Lys 
65                  70                  75                  80  


Glu Asn Pro Glu Glu Lys Leu Phe Ile Val His Lys Ala Ile Thr Asp 
                85                  90                  95      


Leu Ser Leu Gln Glu Thr Ser Ala Asp Glu Met Thr Phe Arg Glu Gly 
            100                 105                 110         


His Gln Trp Glu Lys Ile Pro Leu Ser Gly Ser Asn Gln Glu Ile Arg 
        115                 120                 125             


Arg Gln Lys Glu Arg Ile Thr Glu Gln Pro Leu Lys Glu Glu Glu Asp 
    130                 135                 140                 


Glu Asp Arg Lys Asn Lys Gly His 
145                 150         


<210> 7221
<211> 255
<212> PRT
<213> Homo sapiens

<400> 7221
Met Trp Pro Phe Pro Ser Arg Ser Leu Phe Pro Pro Pro Thr Gln Ala 
1               5                   10                  15      


Trp Leu Gln Thr Val Ser Ser Asp Pro Glu Ala Gln Gly Trp Gly Ala 
            20                  25                  30          


Trp Asn Glu Thr Lys Glu Ile Leu Gly Pro Glu Gly Gly Glu Gly Lys 
        35                  40                  45              


Glu Glu Lys Glu Glu Glu Glu Asp Ala Glu Glu Asp Gln Asp Gly Asp 
    50                  55                  60                  


Ala Gly Phe Leu Leu Ser Leu Leu Glu Gln Glu Asn Leu Ala Glu Cys 
65                  70                  75                  80  


Pro Leu Pro Asp Gln Glu Leu Glu Ala Ile Lys Met Lys Val Cys Ala 
                85                  90                  95      


Met Glu Gln Ala Glu Gly Thr Pro Arg Pro Pro Gly Val Gln Gln Gln 
            100                 105                 110         


Ala Glu Glu Glu Glu Gly Thr Ala Ala Gly Gln Leu Leu Ser Pro Glu 
        115                 120                 125             


Thr Val Gly Cys Pro Leu Ser Gly Thr Pro Glu Glu Lys Val Glu Ala 
    130                 135                 140                 


Asp His Arg Ser Val Tyr Val Gly Asn Val Asp Tyr Gly Gly Ser Ala 
145                 150                 155                 160 


Glu Glu Leu Glu Ala His Phe Ser Arg Cys Gly Glu Val His Arg Val 
                165                 170                 175     


Thr Ile Leu Cys Asp Lys Phe Ser Gly His Pro Lys Gly Cys Cys Arg 
            180                 185                 190         


Lys Glu Pro Thr Ser Leu Gly Ser Ala Pro Gln Thr Ala Gly Ala Phe 
        195                 200                 205             


Glu Asp Thr Gln Ala Pro Gly Gly His Pro Ser Pro Thr Ala Ala Ser 
    210                 215                 220                 


Arg Ala Gly Pro Gly Ser Asp His Lys Gly Arg Thr Gly Pro Val Glu 
225                 230                 235                 240 


Asn Ser His His Gly Phe His Arg Ile Lys Gly Lys Thr Arg Phe 
                245                 250                 255 


<210> 7222
<211> 1186
<212> PRT
<213> Homo sapiens

<400> 7222
Met Glu Lys Ala Thr Val Pro Val Ala Ala Ala Thr Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Thr Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Thr Ala Ser Lys Leu Leu Leu Ser Gly Thr Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Thr Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr 
                325                 330                 335     


Ala Leu Thr Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Thr Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp 
            420                 425                 430         


Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Thr Thr Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Thr Thr Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser 
    770                 775                 780                 


Ser Ser His Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Thr 
785                 790                 795                 800 


Asn Gln Ser Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Thr 
                805                 810                 815     


Glu Leu Glu Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu 
            820                 825                 830         


Gln Ser Leu Glu Leu Ala His Ala Asp Gln Leu Thr Lys Glu Lys Ile 
        835                 840                 845             


Glu Glu Leu Asn Lys Thr Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys 
    850                 855                 860                 


Ile Leu Glu Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Thr 
865                 870                 875                 880 


Gln Gln Gln Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile 
                885                 890                 895     


Gln Leu Gln Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu 
            900                 905                 910         


Thr Pro Val Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg 
        915                 920                 925             


Leu Gln Gln Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Thr 
    930                 935                 940                 


Ala Ala Gln Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln 
945                 950                 955                 960 


Ala Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn 
                965                 970                 975     


Leu Thr Glu Leu Gln Gly Val Ile Val Gly Gln Pro Val Leu Gly Gln 
            980                 985                 990         


Ala Gln Leu Ala Gly Leu Gly Gln  Gly Ile Leu Thr Glu  Thr Gln Gln 
        995                 1000                 1005             


Gly Leu  Met Val Ala Ser Pro  Ala Gln Thr Leu Asn  Asp Thr Leu 
    1010                 1015                 1020             


Asp Asp  Ile Met Ala Ala Val  Ser Gly Arg Ala Ser  Ala Met Ser 
    1025                 1030                 1035             


Asn Thr  Pro Thr His Ser Ile  Ala Ala Ser Ile Ser  Gln Pro Gln 
    1040                 1045                 1050             


Thr Pro  Thr Pro Ser Pro Ile  Ile Ser Pro Ser Ala  Met Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Pro Ala Ile Asp Ile  Asp Ala Gln Thr Glu  Ser Asn His 
    1070                 1075                 1080             


Asp Thr  Ala Leu Thr Leu Ala  Cys Ala Gly Gly His  Glu Glu Leu 
    1085                 1090                 1095             


Val Gln  Thr Leu Leu Glu Arg  Gly Ala Ser Ile Glu  His Arg Asp 
    1100                 1105                 1110             


Lys Lys  Gly Phe Thr Pro Leu  Ile Leu Ala Ala Thr  Ala Gly His 
    1115                 1120                 1125             


Val Gly  Val Val Glu Ile Leu  Leu Asp Asn Gly Ala  Asp Ile Glu 
    1130                 1135                 1140             


Ala Gln  Ser Glu Arg Thr Lys  Asp Thr Pro Leu Ser  Leu Ala Cys 
    1145                 1150                 1155             


Ser Gly  Gly Arg Gln Glu Val  Val Glu Leu Leu Leu  Ala Arg Gly 
    1160                 1165                 1170             


Ala Asn  Lys Ser Thr Gly Met  Phe Leu Ile Thr His  Leu 
    1175                 1180                 1185     


<210> 7223
<211> 893
<212> PRT
<213> Homo sapiens

<400> 7223
Met Ala Ala Thr Val Glu Gly Pro Glu Leu Glu Ala Ala Ala Ala Ala 
1               5                   10                  15      


Gly Asp Ala Ser Glu Asp Ser Asp Ala Gly Ser Arg Ala Leu Pro Phe 
            20                  25                  30          


Leu Gly Gly Asn Arg Leu Ser Leu Asp Leu Tyr Pro Gly Gly Cys Gln 
        35                  40                  45              


Gln Leu Leu His Leu Cys Val Gln Gln Pro Leu Gln Leu Leu Gln Val 
    50                  55                  60                  


Glu Phe Leu Arg Leu Ser Thr His Glu Asp Pro Gln Leu Leu Glu Ala 
65                  70                  75                  80  


Thr Leu Ala Gln Leu Pro Gln Ser Leu Ser Cys Leu Arg Ser Leu Val 
                85                  90                  95      


Leu Lys Gly Gly Gln Arg Arg Asp Thr Leu Gly Ala Cys Leu Arg Gly 
            100                 105                 110         


Ala Leu Thr Asn Leu Pro Ala Gly Leu Ser Gly Leu Ala His Leu Ala 
        115                 120                 125             


His Leu Asp Leu Ser Phe Asn Ser Leu Glu Thr Leu Pro Ala Cys Val 
    130                 135                 140                 


Leu Gln Met Arg Gly Leu Gly Ala Leu Leu Leu Ser His Asn Cys Leu 
145                 150                 155                 160 


Ser Glu Leu Pro Glu Ala Leu Gly Ala Leu Pro Ala Leu Thr Phe Leu 
                165                 170                 175     


Thr Val Thr His Asn Arg Leu Gln Thr Leu Pro Pro Ala Leu Gly Ala 
            180                 185                 190         


Leu Ser Thr Leu Gln Arg Leu Asp Leu Ser Gln Asn Leu Leu Asp Thr 
        195                 200                 205             


Leu Pro Pro Glu Ile Gly Gly Leu Gly Ser Leu Leu Glu Leu Asn Leu 
    210                 215                 220                 


Ala Ser Asn Arg Leu Gln Ser Leu Pro Ala Ser Leu Ala Gly Leu Arg 
225                 230                 235                 240 


Ser Leu Arg Leu Leu Val Leu His Ser Asn Leu Leu Ala Ser Val Pro 
                245                 250                 255     


Ala Asp Leu Ala Arg Leu Pro Leu Leu Thr Arg Leu Asp Leu Arg Asp 
            260                 265                 270         


Asn Gln Leu Arg Asp Leu Pro Pro Glu Leu Leu Asp Ala Pro Phe Val 
        275                 280                 285             


Arg Leu Gln Gly Asn Pro Leu Gly Glu Ala Ser Pro Asp Ala Pro Ser 
    290                 295                 300                 


Ser Pro Val Ala Ala Leu Ile Pro Glu Met Pro Arg Leu Phe Leu Thr 
305                 310                 315                 320 


Ser Asp Leu Asp Ser Phe Pro Val Thr Pro Gln Gly Cys Ser Val Thr 
                325                 330                 335     


Leu Ala Cys Gly Val Arg Leu Gln Phe Pro Ala Gly Ala Thr Ala Thr 
            340                 345                 350         


Pro Ile Thr Ile Arg Tyr Arg Leu Leu Leu Pro Glu Pro Gly Leu Val 
        355                 360                 365             


Pro Leu Gly Pro His Asp Ala Leu Leu Ser His Val Leu Glu Leu Gln 
    370                 375                 380                 


Pro His Gly Val Ala Phe Gln Gln Asp Val Gly Leu Trp Leu Leu Phe 
385                 390                 395                 400 


Thr Pro Pro Gln Ala Arg Arg Cys Arg Glu Val Val Val Arg Thr Arg 
                405                 410                 415     


Asn Asp Asn Ser Trp Gly Asp Leu Glu Thr Tyr Leu Glu Glu Glu Ala 
            420                 425                 430         


Pro Gln Arg Leu Trp Ala His Cys Gln Val Pro His Phe Ser Trp Phe 
        435                 440                 445             


Leu Val Val Ser Arg Pro Val Ser Asn Ala Cys Leu Val Pro Pro Glu 
    450                 455                 460                 


Gly Thr Leu Leu Cys Ser Ser Gly His Pro Gly Val Lys Val Ile Phe 
465                 470                 475                 480 


Pro Pro Gly Ala Thr Glu Glu Pro Arg Arg Val Ser Met Gln Val Val 
                485                 490                 495     


Arg Met Ala Gly Arg Glu Leu Gln Ala Leu Leu Gly Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ser Pro Leu Leu Cys Leu Ser Gln Ser Gly Pro Pro Ser Phe 
        515                 520                 525             


Leu Gln Pro Val Thr Val Gln Leu Pro Leu Pro Ser Gly Ile Thr Gly 
    530                 535                 540                 


Leu Ser Leu Asp Arg Ser Arg Leu His Leu Leu Tyr Trp Ala Pro Pro 
545                 550                 555                 560 


Ala Ala Thr Trp Asp Asp Ile Thr Ala Gln Val Val Leu Glu Leu Thr 
                565                 570                 575     


His Leu Tyr Ala Arg Phe Gln Val Thr His Phe Ser Trp Tyr Trp Leu 
            580                 585                 590         


Trp Tyr Thr Thr Lys Asn Cys Val Gly Gly Leu Ala Arg Lys Ala Trp 
        595                 600                 605             


Glu Arg Leu Arg Leu His Arg Val Asn Leu Ile Ala Leu Gln Arg Arg 
    610                 615                 620                 


Arg Asp Pro Glu Gln Val Leu Leu Gln Cys Leu Pro Arg Asn Lys Val 
625                 630                 635                 640 


Asp Ala Thr Leu Arg Arg Leu Leu Glu Arg Tyr Arg Gly Pro Glu Pro 
                645                 650                 655     


Ser Asp Thr Val Glu Met Phe Glu Gly Glu Glu Phe Phe Ala Ala Phe 
            660                 665                 670         


Glu Arg Gly Ile Asp Val Asp Ala Asp Arg Pro Asp Cys Val Glu Gly 
        675                 680                 685             


Arg Ile Cys Phe Val Phe Tyr Ser His Leu Lys Asn Val Lys Glu Val 
    690                 695                 700                 


Ser Phe Tyr Arg Gly Ala Val Pro Val Arg Val Pro Glu Glu Ala Glu 
705                 710                 715                 720 


Ala Ala Arg Gln Arg Lys Gly Ala Asp Ala Leu Trp Met Ala Thr Leu 
                725                 730                 735     


Pro Ile Lys Leu Pro Arg Leu Arg Gly Ser Glu Gly Pro Arg Arg Gly 
            740                 745                 750         


Ala Gly Leu Ser Leu Ala Pro Leu Asn Leu Gly Asp Ala Glu Thr Gly 
        755                 760                 765             


Phe Leu Thr Gln Ser Asn Leu Leu Ser Val Ala Gly Arg Leu Gly Leu 
    770                 775                 780                 


Asp Trp Pro Ala Val Ala Leu His Leu Gly Val Ser Tyr Arg Glu Val 
785                 790                 795                 800 


Gln Arg Ile Arg His Glu Phe Arg Asp Asp Leu Asp Glu Gln Ile Arg 
                805                 810                 815     


His Met Leu Phe Ser Trp Ala Glu Arg Gln Ala Gly Gln Pro Gly Ala 
            820                 825                 830         


Val Gly Leu Leu Val Gln Ala Leu Glu Gln Ser Asp Arg Gln Asp Val 
        835                 840                 845             


Ala Glu Glu Val Arg Ala Val Leu Glu Leu Gly Arg Arg Lys Tyr Gln 
    850                 855                 860                 


Asp Ser Ile Arg Arg Met Gly Leu Ala Pro Lys Asp Pro Ala Leu Pro 
865                 870                 875                 880 


Gly Ser Ser Ala Pro Gln Pro Pro Glu Pro Ala Gln Ala 
                885                 890             


<210> 7224
<211> 493
<212> PRT
<213> Homo sapiens

<400> 7224
Met Asp Phe Leu Leu Gly Asn Pro Phe Ser Ser Pro Val Gly Gln Arg 
1               5                   10                  15      


Ile Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Ala Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe 
    50                  55                  60                  


His Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn 
65                  70                  75                  80  


Cys Gly His Arg Phe His Val Leu Val Ala Ser Gln Asp Phe Val Glu 
                85                  90                  95      


Ser Val Leu Val Arg Thr Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile 
            100                 105                 110         


Val His Asp Lys Val Leu Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe 
        115                 120                 125             


Arg Ser Ser Pro Asp Leu Thr Gly Val Val Thr Ile Tyr Glu Asp Leu 
    130                 135                 140                 


Arg Arg Lys Gly Leu Glu Phe Pro Met Thr Asp Leu Asp Met Leu Ser 
145                 150                 155                 160 


Pro Ile His Thr Pro Gln Arg Thr Val Phe Asn Ser Glu Thr Gln Ser 
                165                 170                 175     


Gly Gln Asp Ser Val Gly Thr Asp Ser Ser Gln Gln Glu Asp Ser Gly 
            180                 185                 190         


Gln His Ala Ala Pro Leu Pro Ala Pro Pro Ile Leu Ser Gly Asp Thr 
        195                 200                 205             


Pro Ile Ala Pro Thr Pro Glu Gln Ile Gly Lys Leu Arg Ser Glu Leu 
    210                 215                 220                 


Glu Met Val Ser Gly Asn Val Arg Val Met Ser Glu Met Leu Thr Glu 
225                 230                 235                 240 


Leu Val Pro Thr Gln Ala Glu Pro Ala Asp Leu Glu Leu Leu Gln Glu 
                245                 250                 255     


Leu Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Val Leu Glu Leu Ile 
            260                 265                 270         


Pro Gln Ile Ala Asn Glu Gln Leu Thr Glu Glu Leu Leu Ile Val Asn 
        275                 280                 285             


Asp Asn Leu Asn Asn Val Phe Leu Arg His Glu Arg Phe Glu Arg Phe 
    290                 295                 300                 


Arg Thr Gly Gln Thr Thr Lys Ala Pro Ser Glu Ala Glu Pro Ala Ala 
305                 310                 315                 320 


Asp Leu Ile Asp Met Gly Pro Asp Pro Ala Ala Thr Gly Asn Leu Ser 
                325                 330                 335     


Ser Gln Leu Ala Gly Met Asn Leu Gly Ser Ser Ser Val Arg Ala Gly 
            340                 345                 350         


Leu Gln Ser Leu Glu Ala Ser Gly Arg Leu Glu Asp Glu Phe Asp Met 
        355                 360                 365             


Phe Ala Leu Thr Arg Gly Ser Ser Leu Ala Asp Gln Arg Lys Glu Val 
    370                 375                 380                 


Lys Tyr Glu Ala Pro Gln Ala Thr Asp Gly Leu Ala Gly Ala Leu Asp 
385                 390                 395                 400 


Ala Arg Gln Gln Ser Thr Gly Ala Ile Pro Val Thr Gln Ala Cys Leu 
                405                 410                 415     


Met Glu Asp Ile Glu Gln Trp Leu Ser Thr Asp Val Gly Asn Asp Ala 
            420                 425                 430         


Glu Glu Pro Lys Gly Val Thr Ser Glu Gly Lys Phe Asp Lys Phe Leu 
        435                 440                 445             


Glu Glu Arg Ala Lys Ala Ala Asp Arg Leu Pro Asn Leu Ser Ser Pro 
    450                 455                 460                 


Ser Ala Glu Gly Pro Pro Gly Pro Pro Ser Gly Pro Ala Pro Arg Lys 
465                 470                 475                 480 


Lys Thr Gln Glu Lys Asp Asp Asp Met Leu Phe Ala Leu 
                485                 490             


<210> 7225
<211> 220
<212> PRT
<213> Homo sapiens

<400> 7225
Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Pro Ser Arg Thr Val Pro 
1               5                   10                  15      


Ile His Cys Thr Asp Asn Trp Lys Arg Arg Lys Val Leu Glu Gln Thr 
            20                  25                  30          


Pro Val Tyr Arg Ser Leu Ala Gly Arg Gly Trp Ile Lys Tyr Cys Ile 
        35                  40                  45              


Phe Phe Gln Arg Pro Gln Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn 
    50                  55                  60                  


Ser Ser Pro Ser Ile Arg Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr 
65                  70                  75                  80  


Gln Ala Asn Gln His Ile Met Met Val Asn His Leu Pro Met Pro Tyr 
                85                  90                  95      


Pro Val Pro Gln Gly Pro Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser 
            100                 105                 110         


Gly Pro Pro Tyr Val Gly Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro 
        115                 120                 125             


Gly Pro Gly Pro Phe Tyr Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn 
    130                 135                 140                 


Ala Tyr Gly Thr Pro Phe Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala 
145                 150                 155                 160 


Pro Ile Ile Val Pro Thr Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu 
                165                 170                 175     


Lys Lys Thr Ile Arg Ile Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile 
            180                 185                 190         


Thr Glu Glu Ile Met Ser Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro 
        195                 200                 205             


Ile Gly Arg Pro Thr Ser Thr Pro Thr Pro Pro Gln 
    210                 215                 220 


<210> 7226
<211> 137
<212> PRT
<213> Homo sapiens

<400> 7226
Met Ser Leu Phe Gly Thr Thr Ser Gly Phe Gly Thr Ser Gly Thr Ser 
1               5                   10                  15      


Met Phe Gly Ser Ala Thr Thr Asp Asn His Asn Pro Met Lys Asp Ile 
            20                  25                  30          


Glu Val Thr Ser Ser Pro Asp Asp Ser Ile Gly Cys Leu Ser Phe Ser 
        35                  40                  45              


Pro Pro Thr Leu Pro Gly Asn Phe Leu Ile Ala Gly Ser Trp Ala Asn 
    50                  55                  60                  


Asp Val Arg Cys Trp Glu Val Gln Asp Ser Gly Gln Thr Ile Pro Lys 
65                  70                  75                  80  


Ala Gln Gln Met His Thr Gly Pro Val Leu Asp Val Cys Trp Ser Asp 
                85                  90                  95      


Asp Gly Ser Lys Val Phe Thr Ala Ser Cys Asp Lys Thr Ala Lys Met 
            100                 105                 110         


Trp Asp Leu Ser Ser Asn Gln Ala Ile Gln Ile Ala Gln His Asp Ala 
        115                 120                 125             


Pro Val Lys Thr Ile His Trp Ile Lys 
    130                 135         


<210> 7227
<211> 2602
<212> PRT
<213> Homo sapiens

<400> 7227
Met Lys Arg Lys Val Val Asn Thr His Lys Leu Arg Leu Ser Pro Asn 
1               5                   10                  15      


Glu Glu Ala Phe Ile Leu Lys Glu Asp Tyr Glu Arg Arg Arg Lys Leu 
            20                  25                  30          


Arg Leu Leu Gln Val Arg Glu Gln Glu Arg Asp Ile Ala Leu Gln Ile 
        35                  40                  45              


Arg Glu Asp Ile Lys Gln Arg Arg Asn Gln Gln Phe Thr Arg Leu Ala 
    50                  55                  60                  


Glu Glu Leu Arg Ala Glu Trp Glu Glu Ser Gln Thr Gln Lys Ile Gln 
65                  70                  75                  80  


Asn Leu Glu Lys Leu Tyr Leu Ala Ser Leu Arg Ser Met Gly Glu Gly 
                85                  90                  95      


His Arg Gln Ala Lys Glu Asn Glu Pro Asp Leu Asp Ala Leu Ala Gln 
            100                 105                 110         


Arg Ala Ala Glu Arg Lys Arg Lys Ala Asp Leu Arg His Lys Glu Ala 
        115                 120                 125             


Leu Lys Val Gln Lys Asn Gln Lys Glu Ile Leu Leu Lys Gln Lys Thr 
    130                 135                 140                 


Trp His Ile Lys Ala Arg Lys Glu Ala Leu Leu Val Glu Lys Glu Arg 
145                 150                 155                 160 


Ser Ala Lys Ile Thr Ser Leu Pro Pro Pro Pro Pro Thr Leu Phe Glu 
                165                 170                 175     


Asn Ile Glu Val Lys Arg Ile Ser Ala Val Lys Thr Asn Ser Ser Thr 
            180                 185                 190         


Tyr His His Leu His Thr Phe Val Asn Arg Glu Thr Asp Thr Lys Arg 
        195                 200                 205             


Pro Asp Ala Arg Leu Ala Ala Glu Glu Glu Ala Lys Arg Leu Glu Glu 
    210                 215                 220                 


Leu Gln Lys Gln Ala Ala Gln Glu Arg Met Glu Arg Phe Glu Lys Ala 
225                 230                 235                 240 


His Val Arg Gly Phe Gln Ala Met Lys Lys Ile His Leu Ala Gln Asn 
                245                 250                 255     


Gln Glu Lys Leu Met Lys Glu Leu Lys Gln Leu Gln Gln Glu Asp Leu 
            260                 265                 270         


Ala Arg Arg Arg Gln Thr Val Ala Gln Met Pro Pro Gln Leu Val Glu 
        275                 280                 285             


Leu Pro Tyr Lys Arg Ser Glu Met Lys Glu Asp Trp Gln Arg Glu Leu 
    290                 295                 300                 


Glu Phe Ala Phe Glu Asp Met Tyr Asn Ala Asp Arg Lys Val Lys Gly 
305                 310                 315                 320 


Asn Leu Ile Leu His Leu Glu Pro Glu Pro Leu Pro Thr Val Thr Asn 
                325                 330                 335     


Gln Ile Gln Asp Glu Glu Leu Asp Leu Ser Met Glu Gln Glu Asn Leu 
            340                 345                 350         


Gly Ala Ala Glu Asp Leu Pro Val Thr Glu Ala Glu Ile Cys Ser Ser 
        355                 360                 365             


Glu Thr Asp Val Pro Leu Val Met Lys Thr Gln Gln Ile Pro Ser Lys 
    370                 375                 380                 


Val Leu Phe Lys Lys Leu Leu Asn Lys Ile Arg Ser Gln Lys Ser Leu 
385                 390                 395                 400 


Trp Thr Ile Lys Ser Met Ser Glu Asp Glu Ser Glu Met Ile Thr Thr 
                405                 410                 415     


Val Ser Glu Ile Glu Ser Lys Ala Pro Thr Val Glu Ser Gly Thr Ile 
            420                 425                 430         


Ala Ser Lys Glu Arg Thr Leu Ser Ser Gly Gln Glu Gln Val Val Glu 
        435                 440                 445             


Ser Asp Thr Leu Thr Ile Glu Ser Gly Pro Leu Ala Ser Glu Asp Lys 
    450                 455                 460                 


Pro Leu Ser Cys Gly Thr Asn Ser Gly Lys Glu Gln Glu Ile Asn Glu 
465                 470                 475                 480 


Thr Leu Pro Ile Thr Thr Val Ala Gln Ser Ser Val Leu Leu His Pro 
                485                 490                 495     


Gln Glu Ala Ala Ala Arg Ile Arg Met Ser Ala Arg Gln Lys Gln Ile 
            500                 505                 510         


Met Glu Ile Glu Glu Gln Lys Gln Lys Gln Leu Glu Leu Leu Glu Gln 
        515                 520                 525             


Ile Glu Gln Gln Lys Leu Arg Leu Glu Thr Asp Cys Phe Arg Ala Gln 
    530                 535                 540                 


Leu Glu Glu Glu Lys Arg Lys Lys Thr Gln Pro Thr Gly Val Gly Ile 
545                 550                 555                 560 


Ala Pro Ala Ser Cys Pro Val Ile Ser Asp Glu Asp Ser His Arg Gln 
                565                 570                 575     


Met Ile Arg Asn Tyr Gln His Gln Leu Leu Gln Gln Asn Arg Leu His 
            580                 585                 590         


Arg Gln Ser Val Glu Thr Ala Arg Lys Gln Leu Leu Glu Tyr Gln Thr 
        595                 600                 605             


Met Leu Lys Gly Arg Cys Pro Ser Val Ser Ala Pro Ser Leu Ile Thr 
    610                 615                 620                 


Asp Ser Val Ile Ser Val Pro Ser Trp Lys Ser Glu Arg Pro Thr Ala 
625                 630                 635                 640 


Ile Ser Glu His Trp Asp Gln Gly Gln Arg Leu Lys Leu Ser Pro Asn 
                645                 650                 655     


Lys Tyr Gln Pro Ile Gln Pro Ile Gln Thr Ser Lys Leu Glu Gln Asp 
            660                 665                 670         


His Phe Gln Val Ala Arg Gln Asn His Phe Pro Gln Arg Gln Val Glu 
        675                 680                 685             


Thr Thr Glu Thr Leu Arg Ala Ser Asp Ile Leu Thr Asn Gln Ala Leu 
    690                 695                 700                 


Glu Ser Gln Glu His Leu Arg Gln Phe Ser Gln Thr Glu Thr Gln Gln 
705                 710                 715                 720 


Arg Asp Tyr Lys Leu Val Pro Lys Asp Ser Glu Thr Leu Ser Arg Ala 
                725                 730                 735     


Leu Ser His Asp Arg Gln Leu Ile Ser Gln Asp Ala Arg Lys Ile Ser 
            740                 745                 750         


Glu Thr Phe Gly Ala Thr Thr Phe Gln Ser Leu Glu Ser Gln Gln Leu 
        755                 760                 765             


Phe Ser Glu Asn Ser Glu Asn Ile Ser Tyr His Leu Thr Glu Pro Ser 
    770                 775                 780                 


Ser Phe Val Pro Leu Val Pro Gln His Ser Phe Ser Ser Leu Pro Val 
785                 790                 795                 800 


Lys Val Glu Ser Gly Lys Ile Gln Glu Pro Phe Ser Ala Met Ser Lys 
                805                 810                 815     


Ser Thr Val Ser Thr Ser His Ser Ile Ile Ser Gln Met His Asp Arg 
            820                 825                 830         


Pro Leu Leu Pro Ser Glu Asn Ile Thr Ala Gln Gln Gly Asn Met Lys 
        835                 840                 845             


Ala Leu Gln Glu Gln Leu Asp Leu Gln Lys Lys Val Leu Gln Ala Thr 
    850                 855                 860                 


Gln Glu Ala Gln Glu Gln Leu Leu Leu Cys Lys Gln Lys Glu Val Glu 
865                 870                 875                 880 


Gln Gln Thr Gly Leu Ser Val Phe Leu Pro Leu Val Thr Pro Asp Ser 
                885                 890                 895     


Ser Ala Leu Leu Pro Ser Ala Lys Ala Asp Leu Gly Arg Ile Gln Glu 
            900                 905                 910         


Ser Ser Pro Thr Lys Asn Asn Ile Ala Val Ser Ser Asp His His Val 
        915                 920                 925             


Ile Ser Gln Leu Gln Asp Lys Arg Leu Ser Leu Ser Gln Pro Ile Leu 
    930                 935                 940                 


Ser Gln Gln Asn Asn Phe Lys Phe Leu Gln Glu Gln Leu Asn Ile Gln 
945                 950                 955                 960 


Lys Asp Ser Leu Gln Ala Arg Arg Glu Ala Gln Glu Val Leu Tyr Val 
                965                 970                 975     


His Lys Gln Ser Glu Leu Asp Arg Arg Val Cys Ser Glu Gln Ala Glu 
            980                 985                 990         


Pro Ser Phe Pro Phe Gln Val Ala  Gln His Thr Phe Thr  Ser Leu Pro 
        995                 1000                 1005             


Ser Ala  Asp Thr Lys Ser Gly  Lys Ile Gln Glu Gln  His Ser Ser 
    1010                 1015                 1020             


Lys Ser  Glu Lys Gly Leu Val  Ser Cys Gln Ser Asp  Ile Pro Ile 
    1025                 1030                 1035             


Ser Gln  Asp Gly Ser Leu Ser  Phe Leu Gln Gln Phe  Leu Pro Leu 
    1040                 1045                 1050             


His Asp  Ser Leu Lys Leu Leu  Gln Glu Gln Leu Thr  Lys Gln Arg 
    1055                 1060                 1065             


Asp Thr  Leu Gln Ala Arg His  Glu Ala Gln Val Glu  Leu Leu Leu 
    1070                 1075                 1080             


His Arg  Gln Arg Asp Leu Gly  Asp Ser Lys Ser Gly  Leu Val Ser 
    1085                 1090                 1095             


Ser Ser  Ser Ser Pro Val Val  Val Gln His Ser Val  Ala Ser Gln 
    1100                 1105                 1110             


Ala Ser  Ala Lys Ala Glu Pro  Arg Arg Ile Gln Glu  Leu Tyr Leu 
    1115                 1120                 1125             


Ser Glu  Lys Glu Asn Val Gly  Pro Ser Cys His Leu  Ile Ile Pro 
    1130                 1135                 1140             


Thr Phe  Gln Asp Lys Ser Leu  Ser Phe Pro Gln His  Ser Leu Ala 
    1145                 1150                 1155             


Gln Gln  Glu Asn Leu Thr Ile  Leu Gln Glu Gln Ser  Gln Ile Gln 
    1160                 1165                 1170             


Arg Val  Ile Leu Gly Ala Lys  Glu Gly Thr Gln Glu  Phe Val His 
    1175                 1180                 1185             


Thr Glu  Ser Glu Leu Glu Lys  Arg Ile Ser Ser Glu  Gln Thr Gly 
    1190                 1195                 1200             


Thr Ser  Ser Ser Leu Ser Gln  Val Asp Glu Ser Glu  Arg Phe Gln 
    1205                 1210                 1215             


Glu Cys  Ile Ser Ile Lys Ser  Asp Ser Thr Ile Pro  Leu Ser His 
    1220                 1225                 1230             


Pro Lys  Ile Pro Arg Cys Gln  Glu Arg Leu Leu Arg  Val Ser Gln 
    1235                 1240                 1245             


His Met  Leu Pro Leu Gln Asp  Asn Leu Glu Glu His  Gln Ala Trp 
    1250                 1255                 1260             


Leu Asp  Thr Glu Lys Glu Ala  Phe His Phe Ser Gln  Lys Thr Gln 
    1265                 1270                 1275             


Glu Asn  Thr Ser Ser Glu Gln  Thr Gly Ser Ser Ser  Phe Ile Pro 
    1280                 1285                 1290             


Gln Leu  Val Gln Leu Ser Phe  Thr Ser Leu Ala Ser  Ala Glu Ser 
    1295                 1300                 1305             


Gly Thr  Ile Leu Glu Pro Leu  Phe Thr Glu Ser Glu  Ser Lys Ile 
    1310                 1315                 1320             


Phe Ser  Ser His Leu Gln Ile  Pro Gln Leu Gln Asp  Arg Leu Leu 
    1325                 1330                 1335             


Arg Ile  Ser Gln Leu Ile Gln  Pro Gln Gln Asp Asn  Leu Lys Ala 
    1340                 1345                 1350             


Leu Gln  Glu Gln Leu Ala Thr  Gln Arg Glu Ala Ile  Ile Leu Ala 
    1355                 1360                 1365             


Arg Gln  Glu Ala Arg Glu Glu  Leu Leu Leu His Gln  Ser Glu Trp 
    1370                 1375                 1380             


Glu Gly  Arg Ile Ser Pro Glu  Gln Val Asp Thr Ser  Ser Leu Pro 
    1385                 1390                 1395             


Leu Val  Pro Gln His Ser Phe  Ala Ser Leu Pro Leu  Asn Glu Ser 
    1400                 1405                 1410             


Glu Arg  Asn Gln Glu Pro Cys  Ser Ile Asn Ser Asp  Asn Ile Val 
    1415                 1420                 1425             


Ser Ser  Gly His Ser Glu Ile  Pro Thr Leu Pro Asp  Gly Leu Leu 
    1430                 1435                 1440             


Gly Leu  Ser His Leu Val Leu  Pro Gln Gln Asp Asn  Leu Ile Ala 
    1445                 1450                 1455             


Leu Glu  Glu His Leu His Ala  Gln Thr Asp Phe Leu  Pro Ser Ile 
    1460                 1465                 1470             


Glu Lys  Thr Gln Lys Glu Leu  Val Leu Ser Lys Pro  Cys Lys Phe 
    1475                 1480                 1485             


Glu Glu  Lys Val Ser Ser Glu  His Phe Ile Gln Ser  His His Gly 
    1490                 1495                 1500             


Asp Leu  Gln Ala Leu Gln Gln  Gln Leu Asp Thr Gln  Lys Lys Ala 
    1505                 1510                 1515             


Ile Arg  Ser Ile Gln Glu Val  Gln Glu Glu Leu Leu  Leu Gln Arg 
    1520                 1525                 1530             


Leu Ser  Glu Leu Glu Lys Arg  Val Ser Ser Glu Gln  Val Cys Ser 
    1535                 1540                 1545             


Ser Ser  Phe Val Ser Gln Val  Pro Val Ala Asp Ser  Glu Arg Thr 
    1550                 1555                 1560             


Gln Lys  Ser Phe Pro Thr Lys  Ser Asn Asp Thr Leu  Pro Ser Ser 
    1565                 1570                 1575             


His Arg  Glu Ile Pro Arg Leu  Gln Asp Arg Leu Leu  Ser Leu Ser 
    1580                 1585                 1590             


Lys Pro  Ile Leu Pro Gln Gln  Asp Asn Met Thr Ala  Gln Leu Asp 
    1595                 1600                 1605             


Ala Gln  Arg Glu Val Met Tyr  Ser Tyr Glu Lys Pro  Gln Glu Glu 
    1610                 1615                 1620             


Leu Ser  Leu Asn Lys Gln Arg  Lys Leu Asn Lys Ser  Glu Ser Ala 
    1625                 1630                 1635             


Glu His  Thr Ile Pro Ser Leu  Phe Leu Pro Lys Glu  Thr Glu His 
    1640                 1645                 1650             


Ser Phe  Ile Pro Leu Pro Phe  Ala Glu Ala Lys Pro  Lys Ser Thr 
    1655                 1660                 1665             


Cys Glu  Leu Tyr Ser Ser Gln  Asn Glu His Ala Ala  Pro Pro Ser 
    1670                 1675                 1680             


Asn Pro  Val Ile Pro Gly Phe  Gln Asp Arg Leu Leu  Ser Phe Ser 
    1685                 1690                 1695             


Gln Ser  Val Leu Thr Gln Gln  Asp Asn Leu Gly Leu  Gln Lys Gln 
    1700                 1705                 1710             


Leu Asp  Leu Gln Arg Glu Val  Leu His Tyr Ser Gln  Lys Ala Gln 
    1715                 1720                 1725             


Glu Lys  Leu Leu Val Gln Arg  Gln Thr Ala Leu Gln  Gln Gln Ile 
    1730                 1735                 1740             


Gln Lys  His Glu Glu Thr Leu  Lys Asp Phe Phe Lys  Asp Ser Gln 
    1745                 1750                 1755             


Ile Ser  Lys Pro Thr Val Glu  Asn Asp Leu Lys Thr  Gln Lys Met 
    1760                 1765                 1770             


Gly Gln  Leu Arg Asp Trp Phe  Pro Asn Thr Gln Asp  Leu Ala Gly 
    1775                 1780                 1785             


Asn Asp  Gln Glu Asn Ile Arg  His Ala Asp Arg Asn  Asn Ser Asp 
    1790                 1795                 1800             


Asp Asn  His Leu Ala Ser Glu  Asp Thr Ser Ala Lys  Gln Ser Gly 
    1805                 1810                 1815             


Glu His  Leu Glu Lys Asp Leu  Gly Arg Arg Ser Ser  Lys Pro Pro 
    1820                 1825                 1830             


Val Ala  Lys Val Lys Cys Gly  Leu Asp Leu Asn Gln  His Glu Leu 
    1835                 1840                 1845             


Ser Ala  Ile Gln Glu Val Glu  Ser Pro Ala Ile Gly  Arg Thr Ser 
    1850                 1855                 1860             


Ile Leu  Gly Lys Pro Gly Ile  Tyr Glu Asp Arg Asp  Pro Leu Arg 
    1865                 1870                 1875             


Val Ser  Ile Ser Arg Glu Gln  Ser Phe Phe Gly Ser  Pro Leu Ala 
    1880                 1885                 1890             


His Asp  Pro Phe Ser Cys Leu  Gln Leu Val Gly Gln  Glu Asn Val 
    1895                 1900                 1905             


Cys Gly  Asp Asp Tyr Asp Glu  Ala Val Lys Leu Lys  Glu Ser Val 
    1910                 1915                 1920             


Val Glu  Asn His Ala Val Leu  Ser Tyr Ala Val Glu  Glu Glu His 
    1925                 1930                 1935             


Ala Tyr  Leu Gly Pro Thr Val  Lys Pro Asp Asp Lys  Ala Lys Thr 
    1940                 1945                 1950             


Leu Ser  Tyr Glu Pro Leu Ser  Ser Ala Thr Val Ser  Thr Gly Ser 
    1955                 1960                 1965             


Leu Leu  Ser Tyr Glu Asn Thr  Asp Leu Ser Leu Thr  Asp Pro Glu 
    1970                 1975                 1980             


Ser Phe  Ser Glu His Met Asp  Asp Ser Lys Gln Glu  Ser Thr Thr 
    1985                 1990                 1995             


Ser Lys  Glu Glu Glu Thr Asn  Ile Ile Ser Ser Ile  Val Pro Ser 
    2000                 2005                 2010             


Thr Gln  Asp Ile Tyr Gln Arg  Gln Asn Ser Ser Asp  Val His Lys 
    2015                 2020                 2025             


Ser Leu  Leu Pro Ala Val Asp  Glu Thr Thr Cys Gly  His Thr His 
    2030                 2035                 2040             


Phe Gln  Gln Met Ile Asp Lys  Tyr Ile Asn Glu Ala  Asn Leu Ile 
    2045                 2050                 2055             


Pro Glu  Lys Thr Asp Leu Gln  Glu Leu Glu His Ile  Phe Pro Asn 
    2060                 2065                 2070             


Leu His  His Gln Leu Phe Lys  Pro Leu Glu Pro His  Pro Asp Phe 
    2075                 2080                 2085             


Asp Leu  Ser Ser Ser Ser Ser  Gly Ile Ser Pro Asp  Asn Arg Asp 
    2090                 2095                 2100             


Phe Tyr  Gln Arg Ser Asp Ser  Ser Ser Glu Ser His  Cys Ala Thr 
    2105                 2110                 2115             


Gly Leu  Ser Lys Ser Thr Val  Tyr Phe Thr Ala Leu  Arg Arg Thr 
    2120                 2125                 2130             


Ser Met  His Ser Ser Leu Asn  Thr Ser Pro Asn Gln  Gln Pro Asp 
    2135                 2140                 2145             


Thr Asn  Leu Ala His Val Gly  Ala His Ser Phe Ala  Thr Glu Asn 
    2150                 2155                 2160             


Ile Ile  Gly Gly Ser Glu Gln  Cys Phe Glu Gln Leu  Gln Pro Glu 
    2165                 2170                 2175             


Tyr Ser  Ser Gln Glu Glu Ser  Gln His Ala Asp Leu  Pro Ser Ile 
    2180                 2185                 2190             


Phe Ser  Ile Glu Ala Arg Asp  Ser Ser Gln Gly Met  Lys Asn Gln 
    2195                 2200                 2205             


Asn Tyr  Pro Ser Glu Glu His  Thr Glu Ile Leu Gln  Asn Lys Lys 
    2210                 2215                 2220             


Lys Ile  Val His Phe Gln Leu  Ser Ile Gly Asn Leu  Ser Ser Val 
    2225                 2230                 2235             


Tyr Ser  Ser Ser Asp Glu Ala  Asn Val Phe Asp Gln  Leu Asn Val 
    2240                 2245                 2250             


Gln His  Ser Thr Pro Cys Gly  Ser Asn Ser Ser Glu  Cys Ser Thr 
    2255                 2260                 2265             


Lys His  Gln Leu Glu Ser Arg  Lys Glu Ser Met Gly  Phe Glu Glu 
    2270                 2275                 2280             


Leu Ser  Lys Arg Gly Val Val  Thr Met Leu Gln Ser  Gln Gly Leu 
    2285                 2290                 2295             


Ile Glu  Asp Asn Lys Asn Glu  Thr Cys Arg Val Leu  Asp Ile Asn 
    2300                 2305                 2310             


Pro Gln  Val Glu Glu Thr Asp  Ser Arg Leu Cys Val  Arg Thr Val 
    2315                 2320                 2325             


Glu Met  Gly Thr Ser Ile Gln  Ala Pro Tyr Ser Leu  Thr Thr Gln 
    2330                 2335                 2340             


Asn Glu  Lys Tyr Phe Glu Asn  Ser Ala Glu Thr Asp  Ile Pro Lys 
    2345                 2350                 2355             


Ile Thr  Lys Lys Leu Ser Gln  Leu Gly Glu Ser Glu  Leu Phe Ala 
    2360                 2365                 2370             


Ser Ser  Gly Ser Phe Ser Leu  Gln Ser Ser Ile Pro  Val Trp Glu 
    2375                 2380                 2385             


Thr Glu  Thr Gly His Gly Ile  Met Glu Glu Pro Glu  Leu Thr Leu 
    2390                 2395                 2400             


Ile Ser  Thr Thr Asp Thr Ser  Ile Ala Glu Met Asp  Phe Ala Asn 
    2405                 2410                 2415             


Leu Thr  Leu Glu Glu Lys Ser  Glu Asn Glu Ala Lys  Cys Phe Phe 
    2420                 2425                 2430             


Gln Val  Ser Glu Phe Leu Pro  Leu Val Ser Ala Thr  Glu Ala Ser 
    2435                 2440                 2445             


Asp Tyr  Pro Ala Val Ser Glu  Leu Ser Ile Glu Lys  Pro Arg Thr 
    2450                 2455                 2460             


Ala Ser  Thr Ala Glu Thr Pro  Arg Arg Leu Thr Pro  Val Pro Gly 
    2465                 2470                 2475             


Ser Leu  Gln Glu Ala Phe Ile  Lys Arg Lys Lys Ser  Phe Met Glu 
    2480                 2485                 2490             


Arg Ser  His Gln Arg Gln Lys  Glu Ile Arg Asn Lys  Ile His Val 
    2495                 2500                 2505             


Ser Glu  Asn Ser Gln Ile Lys  Thr Val Lys Glu Lys  Pro Ser Ile 
    2510                 2515                 2520             


Ser Ser  Ser Val Ser Arg Leu  Lys Gly Val Asn Lys  Val Arg Ala 
    2525                 2530                 2535             


Ser Phe  Pro Glu Asp Arg Lys  Thr Thr Gln Ala Leu  Arg His Gln 
    2540                 2545                 2550             


Arg Gly  Leu Arg Leu Tyr Asn  Gln Leu Ala Glu Val  Lys Gln Gln 
    2555                 2560                 2565             


Lys Glu  Glu Lys Thr Lys Gln  Glu Ala Tyr Ala Gln  Asn Arg Ala 
    2570                 2575                 2580             


Arg Ala  Lys Glu Phe His Lys  Lys Thr Leu Glu Lys  Leu Arg Ala 
    2585                 2590                 2595             


Lys Asn  Thr Cys 
    2600         


<210> 7228
<211> 533
<212> PRT
<213> Homo sapiens

<400> 7228
Ser Ala Pro Ser Val Gly Asn Asp Met Gly Asn Asp Asp Ala Ile Gly 
1               5                   10                  15      


Gly Asn Val Ser Lys Tyr Ile Val Leu Pro Thr Gly Tyr Cys Gly Gln 
            20                  25                  30          


Pro Lys Lys Gly His Leu Ile Phe Asp Ala Cys Phe Glu Ser Gly Asn 
        35                  40                  45              


Leu Gly Arg Val Asp Gln Val Ser Glu Phe Glu Tyr Asp Leu Phe Ile 
    50                  55                  60                  


Arg Pro Asp Thr Cys Asn Pro Arg Phe Arg Val Trp Phe Asn Phe Thr 
65                  70                  75                  80  


Val Glu Asn Val Lys Glu Ser Gln Arg Val Ile Phe Asn Ile Val Asn 
                85                  90                  95      


Phe Ser Lys Thr Lys Ser Leu Tyr Arg Asp Gly Met Ala Pro Met Val 
            100                 105                 110         


Lys Ser Thr Ser Arg Pro Lys Trp Gln Arg Leu Pro Pro Lys Asn Val 
        115                 120                 125             


Tyr Tyr Tyr Arg Cys Pro Asp His Arg Lys Asn Tyr Val Met Ser Phe 
    130                 135                 140                 


Ala Phe Cys Phe Asp Arg Glu Glu Asp Ile Tyr Gln Phe Ala Tyr Cys 
145                 150                 155                 160 


Tyr Pro Tyr Thr Tyr Thr Arg Phe Gln His Tyr Leu Asp Ser Leu Gln 
                165                 170                 175     


Lys Arg Asn Met Asp Tyr Phe Phe Arg Glu Gln Leu Gly Gln Ser Val 
            180                 185                 190         


Gln Gln Arg Lys Leu Asp Leu Leu Thr Ile Thr Ser Pro Asp Asn Leu 
        195                 200                 205             


Arg Glu Gly Ala Glu Gln Lys Val Val Phe Ile Thr Gly Arg Val His 
    210                 215                 220                 


Pro Gly Glu Thr Pro Ser Ser Phe Val Cys Gln Gly Ile Ile Asp Phe 
225                 230                 235                 240 


Leu Val Ser Gln His Pro Ile Ala Cys Val Leu Arg Glu Tyr Leu Val 
                245                 250                 255     


Phe Lys Ile Ala Pro Met Leu Asn Pro Asp Gly Val Tyr Leu Gly Asn 
            260                 265                 270         


Tyr Arg Cys Ser Leu Met Gly Phe Asp Leu Asn Arg His Trp Leu Asp 
        275                 280                 285             


Pro Ser Pro Trp Val His Pro Thr Leu His Gly Val Lys Gln Leu Ile 
    290                 295                 300                 


Val Gln Met Tyr Asn Asp Pro Lys Thr Ser Leu Glu Phe Tyr Ile Asp 
305                 310                 315                 320 


Ile His Ala His Ser Thr Met Met Asn Gly Phe Met Tyr Gly Asn Ile 
                325                 330                 335     


Phe Glu Asp Glu Glu Arg Phe Gln Arg Gln Ala Ile Phe Pro Lys Leu 
            340                 345                 350         


Leu Cys Gln Asn Ala Glu Asp Phe Ser Tyr Ser Ser Thr Ser Phe Asn 
        355                 360                 365             


Arg Asp Ala Val Lys Ala Gly Thr Gly Arg Arg Phe Leu Gly Gly Leu 
    370                 375                 380                 


Leu Asp His Thr Ser Tyr Cys Tyr Thr Leu Glu Val Ser Phe Tyr Ser 
385                 390                 395                 400 


Tyr Ile Ile Ser Gly Thr Thr Ala Ala Val Pro Tyr Thr Glu Glu Ala 
                405                 410                 415     


Tyr Met Lys Leu Gly Arg Asn Val Ala Arg Thr Phe Leu Asp Tyr Tyr 
            420                 425                 430         


Arg Leu Asn Pro Val Val Glu Lys Val Ala Ile Pro Met Pro Arg Leu 
        435                 440                 445             


Arg Asn Lys Glu Ile Glu Val Gln Arg Arg Lys Glu Lys Ser Pro Pro 
    450                 455                 460                 


Tyr Lys His Pro Leu Leu Arg Gly Pro Ala Ser Asn Tyr Pro Asn Ser 
465                 470                 475                 480 


Lys Gly Asp Lys Lys Ser Ser Val Asn His Lys Asp Pro Ser Thr Pro 
                485                 490                 495     


Phe Lys Thr Arg Ser Pro Gly Arg Ser Tyr Gly Asp Arg Ser Met His 
            500                 505                 510         


Phe Leu Leu Gly Asn Glu Ile Asn His Ser Ser Leu Ala Ser Lys Asp 
        515                 520                 525             


Leu Trp Ile Asn Ala 
    530             


<210> 7229
<211> 502
<212> PRT
<213> Homo sapiens

<400> 7229
Met Pro Glu Ile Arg Val Thr Pro Leu Gly Ala Cys Pro Val Leu Ser 
1               5                   10                  15      


Trp Asn Leu Val Leu Pro Pro Gly Arg Gly Ser Arg Ala Pro Ser Ser 
            20                  25                  30          


Thr Asp Thr Arg Thr Gly Phe His Val Leu Pro His Gly Val Asp Asp 
        35                  40                  45              


Glu Leu Glu Ile Lys Ala Tyr Tyr Ala Gly His Val Leu Gly Ala Ala 
    50                  55                  60                  


Met Phe Gln Ile Lys Val Gly Ser Glu Ser Val Val Tyr Thr Gly Asp 
65                  70                  75                  80  


Tyr Asn Met Thr Pro Asp Arg His Leu Gly Ala Ala Trp Ile Asp Lys 
                85                  90                  95      


Cys Arg Pro Asn Leu Leu Ile Thr Glu Ser Thr Tyr Ala Thr Thr Ile 
            100                 105                 110         


Arg Asp Ser Lys Arg Cys Arg Glu Arg Asp Phe Leu Lys Lys Val His 
        115                 120                 125             


Glu Thr Val Glu Arg Gly Gly Lys Val Leu Ile Pro Val Phe Ala Leu 
    130                 135                 140                 


Gly Arg Ala Gln Glu Leu Cys Ile Leu Leu Glu Thr Phe Trp Glu Arg 
145                 150                 155                 160 


Met Asn Leu Lys Val Pro Ile Tyr Phe Ser Thr Gly Leu Thr Glu Lys 
                165                 170                 175     


Ala Asn His Tyr Tyr Lys Leu Phe Ile Pro Trp Thr Asn Gln Lys Ile 
            180                 185                 190         


Arg Lys Thr Phe Val Gln Arg Asn Met Phe Glu Phe Lys His Ile Lys 
        195                 200                 205             


Ala Phe Asp Arg Ala Phe Ala Asp Asn Pro Gly Pro Met Val Val Phe 
    210                 215                 220                 


Ala Thr Pro Gly Met Leu His Ala Gly Gln Ser Leu Gln Ile Phe Arg 
225                 230                 235                 240 


Lys Trp Ala Gly Asn Glu Lys Asn Met Val Ile Met Pro Gly Tyr Cys 
                245                 250                 255     


Val Gln Gly Thr Val Gly His Lys Ile Leu Ser Gly Gln Arg Lys Leu 
            260                 265                 270         


Glu Met Glu Gly Arg Gln Val Leu Glu Val Lys Met Gln Val Glu Tyr 
        275                 280                 285             


Met Ser Phe Ser Ala His Ala Asp Ala Lys Gly Ile Met Gln Leu Val 
    290                 295                 300                 


Gly Gln Ala Glu Pro Glu Ser Val Leu Leu Val His Gly Glu Ala Lys 
305                 310                 315                 320 


Lys Met Glu Phe Leu Lys Gln Lys Ile Glu Gln Glu Leu Arg Val Asn 
                325                 330                 335     


Cys Tyr Met Pro Ala Asn Gly Glu Thr Val Thr Leu Pro Thr Ser Pro 
            340                 345                 350         


Ser Ile Pro Val Gly Ile Ser Leu Gly Leu Leu Lys Arg Glu Met Ala 
        355                 360                 365             


Gln Gly Leu Leu Pro Glu Ala Lys Lys Pro Arg Leu Leu His Gly Thr 
    370                 375                 380                 


Leu Ile Met Lys Asp Ser Asn Phe Arg Leu Val Ser Ser Glu Gln Ala 
385                 390                 395                 400 


Leu Lys Glu Leu Gly Leu Ala Glu His Gln Leu Arg Phe Thr Cys Arg 
                405                 410                 415     


Val His Leu His Asp Thr Arg Lys Glu Gln Glu Thr Ala Leu Arg Val 
            420                 425                 430         


Tyr Ser His Leu Lys Ser Val Leu Lys Asp His Cys Val Gln His Leu 
        435                 440                 445             


Pro Asp Gly Ser Val Thr Val Glu Ser Val Leu Leu Gln Ala Ala Ala 
    450                 455                 460                 


Pro Ser Glu Asp Pro Gly Thr Lys Val Leu Leu Val Ser Trp Thr Tyr 
465                 470                 475                 480 


Gln Asp Glu Glu Leu Gly Ser Phe Leu Thr Ser Leu Leu Lys Lys Gly 
                485                 490                 495     


Leu Pro Gln Ala Pro Ser 
            500         


<210> 7230
<211> 456
<212> PRT
<213> Homo sapiens

<400> 7230
Met Ala Asp Ser Leu Glu Ser Thr Pro Leu Pro Ser Pro Glu Asp Arg 
1               5                   10                  15      


Leu Ala Lys Leu His Pro Ser Lys Glu Leu Leu Glu Tyr Tyr Gln Lys 
            20                  25                  30          


Lys Met Ala Glu Cys Glu Ala Glu Asn Glu Asp Leu Leu Lys Lys Leu 
        35                  40                  45              


Glu Leu Tyr Lys Glu Ala Cys Glu Gly Gln His Lys Leu Glu Cys Asp 
    50                  55                  60                  


Leu Gln Gln Arg Glu Glu Glu Ile Ala Glu Leu Gln Lys Ala Leu Ser 
65                  70                  75                  80  


Asp Met Gln Val Cys Leu Phe Gln Glu Arg Glu His Val Leu Arg Leu 
                85                  90                  95      


Tyr Ser Glu Asn Asp Arg Leu Arg Ile Arg Glu Leu Glu Asp Lys Lys 
            100                 105                 110         


Lys Ile Gln Asn Leu Leu Ala Leu Val Gly Thr Asp Ala Gly Glu Val 
        115                 120                 125             


Thr Tyr Phe Cys Lys Glu Pro Pro His Lys Val Thr Ile Leu Gln Lys 
    130                 135                 140                 


Thr Ile Gln Ala Val Gly Glu Cys Glu Gln Ser Glu Ser Ser Ala Phe 
145                 150                 155                 160 


Lys Ala Asp Pro Lys Ile Ser Lys Arg Arg Pro Ser Arg Glu Arg Lys 
                165                 170                 175     


Glu Ser Ser Glu His Tyr Gln Arg Asp Ile Gln Thr Leu Ile Leu Gln 
            180                 185                 190         


Val Glu Ala Leu Gln Ala Gln Leu Gly Glu Gln Thr Lys Leu Ser Arg 
        195                 200                 205             


Glu Gln Ile Glu Gly Leu Ile Glu Asp Arg Arg Ile His Leu Glu Glu 
    210                 215                 220                 


Ile Gln Val Gln His Gln Arg Asn Gln Asn Lys Ile Lys Glu Leu Thr 
225                 230                 235                 240 


Lys Asn Leu His His Thr Gln Glu Leu Leu Tyr Glu Ser Thr Lys Asp 
                245                 250                 255     


Phe Leu Gln Leu Arg Ser Glu Asn Gln Asn Lys Glu Lys Ser Trp Met 
            260                 265                 270         


Leu Glu Lys Asp Asn Leu Met Ser Lys Ile Lys Gln Tyr Arg Val Gln 
        275                 280                 285             


Cys Lys Lys Lys Glu Asp Lys Ile Gly Lys Val Leu Pro Val Met His 
    290                 295                 300                 


Glu Ser His His Ala Gln Ser Glu Tyr Ile Lys Ser Leu Lys Asp Lys 
305                 310                 315                 320 


Leu Val Gln Glu Lys Lys Leu Ser Asn Met Tyr Gln Glu Gln Cys Ile 
                325                 330                 335     


Ser Leu Glu Glu Glu Leu Ala Arg Ile Arg Glu Glu Glu Gly Met Arg 
            340                 345                 350         


Arg Glu Ile Phe Lys Asp Arg Thr Asn Lys Met Gly Lys Arg Leu Gln 
        355                 360                 365             


Ile Met Thr Lys Arg Tyr Glu Ala Leu Glu Arg Arg Arg Ile Leu Glu 
    370                 375                 380                 


Val Glu Gly Phe Lys Thr Asp Ile Lys Val Leu Arg Gln Lys Leu Lys 
385                 390                 395                 400 


Asp Leu Glu Gln Met Leu Tyr Lys Ala Thr Val Asn Ala Arg Ala Asn 
                405                 410                 415     


Gln Asp Leu Ala Leu Leu Cys Glu Val Arg Asp Ser Asn Arg Arg Ala 
            420                 425                 430         


His Lys Ile Gln Gly Glu Leu Lys Asn Leu Lys Ser Lys Val Phe Gly 
        435                 440                 445             


Leu Glu Asn Glu Leu Arg Leu Cys 
    450                 455     


<210> 7231
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7231
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 7232
<211> 150
<212> PRT
<213> Homo sapiens

<400> 7232
Met His Pro Glu Asp Ser Val Val Ser Ser Lys Val Leu Gly Cys Ser 
1               5                   10                  15      


His Phe Pro Val Ala Ser Arg Pro Ala Gly Ser His Asp Pro Gln Pro 
            20                  25                  30          


Gly His Arg Gly Arg Val Leu Gly Pro Ala Arg Ala Pro Gly Trp Val 
        35                  40                  45              


Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile Thr Ala His Leu Cys 
    50                  55                  60                  


Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser Leu Val Lys Asp Tyr 
65                  70                  75                  80  


Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys Ile Phe His Val Ile 
                85                  90                  95      


Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala Leu Gln Glu Ser Leu 
            100                 105                 110         


Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp Cys Val Leu Thr Ser 
        115                 120                 125             


Gly Glu Ile Ala Gln Ile Met Glu Gln Gly Asp Leu Ser Val Arg Asp 
    130                 135                 140                 


Ala Ala Val Asp Thr Leu 
145                 150 


<210> 7233
<211> 177
<212> PRT
<213> Homo sapiens

<400> 7233
Met Gly Cys Cys Gly Cys Ser Arg Gly Cys Gly Ser Gly Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Ser Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly 
            20                  25                  30          


Ser Gly Arg Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Ser Ser Ser 
        35                  40                  45              


Cys Gly Gly Cys Gly Ser Arg Cys Tyr Val Pro Val Cys Cys Cys Lys 
    50                  55                  60                  


Pro Val Cys Ser Trp Val Pro Ala Cys Ser Cys Thr Ser Cys Gly Ser 
65                  70                  75                  80  


Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly 
                85                  90                  95      


Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly 
            100                 105                 110         


Cys Ser Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys 
        115                 120                 125             


Gly Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln 
    130                 135                 140                 


Ser Ser Cys Cys Val Pro Val Cys Cys Gln Ser Ser Cys Cys Lys Pro 
145                 150                 155                 160 


Cys Cys Cys Gln Ser Asn Cys Cys Val Pro Val Cys Cys Gln Cys Lys 
                165                 170                 175     


Ile 
    


<210> 7234
<211> 97
<212> PRT
<213> Homo sapiens

<400> 7234
Met Pro Ala Glu Leu Trp Leu Thr Ser Tyr Gly Val Arg Glu Val Asp 
1               5                   10                  15      


Gln Val Lys Arg Leu Thr Gly Pro Gly Leu Ser Glu Gly Pro Glu Pro 
            20                  25                  30          


Ser Ile Ser Val Met Val Thr Gly Gly Pro Trp Pro Thr Arg Leu Ser 
        35                  40                  45              


Arg Thr Cys Leu His Tyr Leu Gly Glu Phe Gly Glu Asp Gln Ile Tyr 
    50                  55                  60                  


Glu Ala His Gln Gln Gly Arg Gly Ala Leu Glu Ala Leu Leu Cys Gly 
65                  70                  75                  80  


Gly Pro Gln Gly Ala Cys Ser Glu Lys Val Ser Ala Thr Arg Glu Glu 
                85                  90                  95      


Leu 
    


<210> 7235
<211> 87
<212> PRT
<213> Homo sapiens

<400> 7235
Met Glu Asn Gln Leu Ala Lys Ser Thr Glu Glu Arg Thr Phe Gln Tyr 
1               5                   10                  15      


Gln Asp Ser Leu Pro Ser Leu Pro Val Pro Ser Leu Glu Glu Ser Leu 
            20                  25                  30          


Lys Lys Tyr Leu Glu Ser Val Lys Pro Phe Ala Asn Gln Glu Glu Tyr 
        35                  40                  45              


Lys Lys Thr Glu Glu Ile Val Gln Lys Phe Gln Ser Gly Ile Gly Glu 
    50                  55                  60                  


Lys Leu His Gln Lys Leu Leu Glu Arg Ala Lys Gly Lys Arg Asn Trp 
65                  70                  75                  80  


Val Phe Val Val Ile Ile Glu 
                85          


<210> 7236
<211> 626
<212> PRT
<213> Homo sapiens

<400> 7236
Met Cys Ser Thr Leu Lys Lys Cys Gly Thr Tyr Arg Thr Glu Val Ala 
1               5                   10                  15      


Glu Cys His Asp His Gly Ser Thr Phe Gln Gly Arg Lys Lys Gly Gly 
            20                  25                  30          


Ser Ser Phe Arg Asp Asn Phe Asp Lys Arg Ser Cys His Tyr Glu His 
        35                  40                  45              


Gly Gly Tyr Glu Arg Pro Pro Ser His Cys Gln Glu Asn Asp Gly Ser 
    50                  55                  60                  


Val Glu Met Arg Asp Val His Lys Asp Gln Gln Leu Arg His Thr Pro 
65                  70                  75                  80  


Tyr Ser Ile Arg Cys Glu Arg Arg Met Lys Trp His Ser Glu Asp Glu 
                85                  90                  95      


Ile Arg Ile Thr Thr Trp Arg Asn Arg Lys Pro Pro Glu Arg Lys Met 
            100                 105                 110         


Ser Gln Asn Thr Gln Asp Gly Tyr Thr Arg Asn Trp Phe Lys Val Thr 
        115                 120                 125             


Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser Ile 
    130                 135                 140                 


Gln Ser His Cys Ser Asp Arg Phe Thr Pro Val Asp Phe His Tyr Val 
145                 150                 155                 160 


Arg Asn Arg Ala Cys Phe Phe Val Gln Asp Ala Ser Ala Ala Ser Ala 
                165                 170                 175     


Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys Ile 
            180                 185                 190         


Cys Ile Phe Val Asn His Ser Thr Ala Pro Tyr Ser Val Lys Asn Lys 
        195                 200                 205             


Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys Arg 
    210                 215                 220                 


Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe Asp 
225                 230                 235                 240 


Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg Asn 
                245                 250                 255     


Cys Met Ala Ala Thr Leu Lys Ile Ile Glu Arg Asn Phe Pro Glu Leu 
            260                 265                 270         


Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp Gly Leu 
        275                 280                 285             


Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn Leu Ser 
    290                 295                 300                 


Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys Gly Leu 
305                 310                 315                 320 


Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser Thr Phe 
                325                 330                 335     


Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe Pro Lys 
            340                 345                 350         


Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile Val Asp 
        355                 360                 365             


Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe Thr Gly 
    370                 375                 380                 


Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln Tyr Tyr 
385                 390                 395                 400 


Ser Ile Tyr Asp Ser Gly Asp Arg Gln Gly Leu Leu Gly Ala Tyr His 
                405                 410                 415     


Asp Glu Ala Cys Phe Ser Leu Ala Ile Pro Phe Asp Pro Lys Asp Ser 
            420                 425                 430         


Ala Pro Ser Ser Leu Cys Lys Tyr Phe Glu Asp Ser Arg Asn Met Lys 
        435                 440                 445             


Thr Leu Lys Asp Pro Tyr Leu Lys Gly Glu Leu Leu Arg Arg Thr Lys 
    450                 455                 460                 


Arg Asp Ile Val Asp Ser Leu Ser Ala Leu Pro Lys Thr Gln His Asp 
465                 470                 475                 480 


Leu Ser Ser Ile Leu Val Asp Val Trp Cys Gln Thr Glu Arg Met Leu 
                485                 490                 495     


Cys Phe Ser Val Asn Gly Val Phe Lys Glu Val Glu Gly Gln Ser Gln 
            500                 505                 510         


Gly Ser Val Leu Ala Phe Thr Arg Thr Phe Ile Ala Thr Pro Gly Ser 
        515                 520                 525             


Ser Ser Ser Leu Cys Ile Val Asn Asp Glu Leu Phe Val Arg Asp Ala 
    530                 535                 540                 


Ser Pro Gln Glu Thr Gln Ser Ala Phe Ser Ile Pro Val Ser Thr Leu 
545                 550                 555                 560 


Ser Ser Ser Ser Glu Pro Ser Leu Ser Gln Glu Gln Gln Glu Met Val 
                565                 570                 575     


Gln Ala Phe Ser Ala Gln Ser Gly Met Lys Leu Glu Trp Ser Gln Lys 
            580                 585                 590         


Cys Leu Gln Asp Asn Glu Trp Asn Tyr Thr Arg Ala Gly Gln Ala Phe 
        595                 600                 605             


Thr Met Leu Gln Thr Glu Gly Lys Ile Pro Ala Glu Ala Phe Lys Gln 
    610                 615                 620                 


Ile Ser 
625     


<210> 7237
<211> 979
<212> PRT
<213> Homo sapiens

<400> 7237
Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 
65                  70                  75                  80  


Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 
                85                  90                  95      


Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 
        115                 120                 125             


Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 
    130                 135                 140                 


Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 
145                 150                 155                 160 


Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 
                165                 170                 175     


Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 
            180                 185                 190         


Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 
        195                 200                 205             


Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 
    210                 215                 220                 


Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 
225                 230                 235                 240 


Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 
                245                 250                 255     


Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 
            260                 265                 270         


Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 
        275                 280                 285             


Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 
305                 310                 315                 320 


Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 
                325                 330                 335     


Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 
            340                 345                 350         


Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 
    370                 375                 380                 


Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 
385                 390                 395                 400 


Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 
                405                 410                 415     


Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 
            420                 425                 430         


Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 
        435                 440                 445             


Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 
    450                 455                 460                 


Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 
465                 470                 475                 480 


Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 
                485                 490                 495     


Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 
            500                 505                 510         


Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 
        515                 520                 525             


Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 
    530                 535                 540                 


Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 
545                 550                 555                 560 


Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 
                565                 570                 575     


Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 
            580                 585                 590         


Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 
        595                 600                 605             


Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 
    610                 615                 620                 


Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 
625                 630                 635                 640 


Gly Met Asp Val Asn His Gly Leu Thr Glu Leu Ala Asp Ile Pro Val 
                645                 650                 655     


Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr Thr 
            660                 665                 670         


Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp Gln 
        675                 680                 685             


Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu Ser 
    690                 695                 700                 


Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val Gly 
705                 710                 715                 720 


Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys Lys 
                725                 730                 735     


Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly Gly 
            740                 745                 750         


Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp Pro 
        755                 760                 765             


Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp Phe 
    770                 775                 780                 


Ser Asp Lys Ile Thr Val Glu Asn Phe Gly Ala Thr Glu Val Lys Glu 
785                 790                 795                 800 


Leu Val Leu Asn Gly Ala Asp Thr Ala Val Asn Lys Gln Asn Arg Gln 
                805                 810                 815     


Glu Phe Val Asp Ala Tyr Val Asp Tyr Ile Phe Asn Lys Ser Val Ala 
            820                 825                 830         


Ser Leu Phe Asp Ala Phe His Ala Gly Phe His Lys Val Cys Gly Gly 
        835                 840                 845             


Lys Val Leu Leu Leu Phe Gln Pro Asn Glu Leu Gln Ala Met Val Ile 
    850                 855                 860                 


Gly Asn Thr Asn Tyr Asp Trp Lys Glu Leu Glu Lys Asn Thr Glu Tyr 
865                 870                 875                 880 


Lys Gly Glu Tyr Trp Ala Glu His Pro Thr Ile Lys Ile Phe Trp Glu 
                885                 890                 895     


Val Phe His Glu Leu Pro Leu Glu Lys Lys Lys Gln Phe Leu Leu Phe 
            900                 905                 910         


Leu Thr Gly Ser Asp Arg Ile Pro Ile Leu Gly Met Lys Ser Leu Lys 
        915                 920                 925             


Leu Val Ile Gln Ser Thr Gly Gly Gly Glu Glu Tyr Leu Pro Val Ser 
    930                 935                 940                 


His Thr Cys Phe Asn Leu Leu Asp Leu Pro Lys Tyr Thr Glu Lys Glu 
945                 950                 955                 960 


Thr Leu Arg Ser Lys Leu Ile Gln Ala Ile Asp His Asn Glu Gly Phe 
                965                 970                 975     


Ser Leu Ile 
            


<210> 7238
<211> 339
<212> PRT
<213> Homo sapiens

<400> 7238
Met Lys Ile Phe Val Gly Asn Val Asp Gly Ala Asp Thr Thr Pro Glu 
1               5                   10                  15      


Glu Leu Ala Ala Leu Phe Ala Pro Tyr Gly Thr Val Met Ser Cys Ala 
            20                  25                  30          


Val Met Lys Gln Phe Ala Phe Val His Met Arg Glu Asn Ala Gly Ala 
        35                  40                  45              


Leu Arg Ala Ile Glu Ala Leu His Gly His Glu Leu Arg Pro Gly Arg 
    50                  55                  60                  


Ala Leu Val Val Glu Met Ser Arg Pro Arg Pro Leu Asn Thr Trp Lys 
65                  70                  75                  80  


Ile Phe Val Gly Asn Val Ser Ala Ala Cys Thr Ser Gln Glu Leu Arg 
                85                  90                  95      


Ser Leu Phe Glu Arg Arg Gly Arg Val Ile Glu Cys Asp Val Val Lys 
            100                 105                 110         


Gly Lys Arg Met His Val Gln Leu Ser Thr Ser Arg Leu Arg Thr Ala 
        115                 120                 125             


Pro Gly Met Gly Asp Gln Ser Gly Cys Tyr Arg Cys Gly Lys Glu Gly 
    130                 135                 140                 


His Trp Ser Lys Glu Cys Pro Ile Asp Arg Ser Gly Arg Val Ala Asp 
145                 150                 155                 160 


Leu Thr Glu Gln Tyr Asn Glu Gln Tyr Gly Ala Val Arg Thr Pro Tyr 
                165                 170                 175     


Thr Met Ser Tyr Gly Asp Ser Leu Tyr Tyr Asn Asn Ala Tyr Gly Ala 
            180                 185                 190         


Leu Asp Ala Tyr Tyr Lys Arg Cys Arg Ala Ala Arg Ser Tyr Glu Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ser Val Tyr Asn Tyr Ala Glu Gln Thr Leu 
    210                 215                 220                 


Ser Gln Leu Pro Gln Val Gln Asn Thr Ala Met Ala Ser His Leu Thr 
225                 230                 235                 240 


Ser Thr Ser Leu Asp Pro Tyr Asp Arg His Leu Leu Pro Thr Ser Gly 
                245                 250                 255     


Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Thr 
            260                 265                 270         


Ala Ala Ser Thr Ser Tyr Tyr Gly Arg Asp Arg Ser Pro Leu Arg Arg 
        275                 280                 285             


Ala Thr Ala Pro Val Pro Thr Val Gly Glu Gly Tyr Gly Tyr Gly His 
    290                 295                 300                 


Glu Ser Glu Leu Ser Gln Ala Ser Ala Ala Ala Arg Asn Ser Leu Tyr 
305                 310                 315                 320 


Asp Met Ala Arg Tyr Glu Arg Glu Gln Tyr Ala Asp Arg Ala Arg Tyr 
                325                 330                 335     


Ser Ala Phe 
            


<210> 7239
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7239
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7240
<211> 564
<212> PRT
<213> Homo sapiens

<400> 7240
Met Ser Tyr Pro Ala Asp Asp Tyr Glu Ser Glu Ala Ala Tyr Asp Pro 
1               5                   10                  15      


Tyr Ala Tyr Pro Ser Asp Tyr Asp Met His Thr Gly Asp Pro Lys Gln 
            20                  25                  30          


Asp Leu Ala Tyr Glu Arg Gln Tyr Glu Gln Gln Thr Tyr Gln Val Ile 
        35                  40                  45              


Pro Glu Val Ile Lys Asn Phe Ile Gln Tyr Phe His Lys Thr Val Ser 
    50                  55                  60                  


Asp Leu Ile Asp Gln Lys Val Tyr Glu Leu Gln Ala Ser Arg Val Ser 
65                  70                  75                  80  


Ser Asp Val Ile Asp Gln Lys Val Tyr Glu Ile Gln Asp Ile Tyr Glu 
                85                  90                  95      


Asn Ser Trp Thr Lys Leu Thr Glu Arg Phe Phe Lys Asn Thr Pro Trp 
            100                 105                 110         


Pro Glu Ala Glu Ala Ile Ala Pro Gln Val Gly Asn Asp Ala Val Phe 
        115                 120                 125             


Leu Ile Leu Tyr Lys Glu Leu Tyr Tyr Arg His Ile Tyr Ala Lys Val 
    130                 135                 140                 


Ser Gly Gly Pro Ser Leu Glu Gln Arg Phe Glu Ser Tyr Tyr Asn Tyr 
145                 150                 155                 160 


Cys Asn Leu Phe Asn Tyr Ile Leu Asn Ala Asp Gly Pro Ala Pro Leu 
                165                 170                 175     


Glu Leu Pro Asn Gln Trp Leu Trp Asp Ile Ile Asp Glu Phe Ile Tyr 
            180                 185                 190         


Gln Phe Gln Ser Phe Ser Gln Tyr Arg Cys Lys Thr Ala Lys Lys Ser 
        195                 200                 205             


Glu Glu Glu Ile Asp Phe Leu Arg Ser Asn Pro Lys Ile Trp Asn Val 
    210                 215                 220                 


His Ser Val Leu Asn Val Leu His Ser Leu Val Asp Lys Ser Asn Ile 
225                 230                 235                 240 


Asn Arg Gln Leu Glu Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val 
                245                 250                 255     


Ala Gly Glu Tyr Gly Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe 
            260                 265                 270         


Ser Leu Val Gly Leu Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr 
        275                 280                 285             


Gln Ala Ile Lys Val Leu Glu Asn Ile Glu Leu Asn Lys Lys Ser Met 
    290                 295                 300                 


Tyr Ser Arg Val Pro Glu Cys Gln Val Thr Thr Tyr Tyr Tyr Val Gly 
305                 310                 315                 320 


Phe Ala Tyr Leu Met Met Arg Arg Tyr Gln Asp Ala Ile Arg Val Phe 
                325                 330                 335     


Ala Asn Ile Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln Arg 
            340                 345                 350         


Thr Thr Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met His 
        355                 360                 365             


Ala Leu Leu Ala Ile Ala Leu Thr Met Tyr Pro Met Arg Ile Asp Glu 
    370                 375                 380                 


Ser Ile His Leu Gln Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg 
385                 390                 395                 400 


Met Gln Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr Ser 
                405                 410                 415     


Cys Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val His 
            420                 425                 430         


Pro Asn Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe Ser 
        435                 440                 445             


Asp Glu Val Gln Gln Gln Ala Gln Leu Ser Thr Ile Arg Ser Phe Leu 
    450                 455                 460                 


Lys Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp 
465                 470                 475                 480 


Leu Thr Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His Lys 
                485                 490                 495     


Met Lys Asn Leu Val Trp Thr Ser Gly Ile Ser Ala Leu Asp Gly Glu 
            500                 505                 510         


Phe Gln Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met Ile 
        515                 520                 525             


His Ile Ala Asp Thr Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe Ile 
    530                 535                 540                 


Arg Gln Ile His Lys Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met 
545                 550                 555                 560 


Gly Gln Arg Pro 
                


<210> 7241
<211> 262
<212> PRT
<213> Homo sapiens

<400> 7241
Met Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly 
            20                  25                  30          


Gln Cys Pro Trp Arg Gly Ala Gly Ser Phe Leu Asp Pro Glu Ile Lys 
        35                  40                  45              


Ala Phe Leu Glu Glu Asn Thr Glu Val Thr Ser Ser Gly Ser Leu Thr 
    50                  55                  60                  


Pro Glu Ile Gln Leu Arg Leu Leu Thr Pro Arg Cys Lys Phe Trp Trp 
65                  70                  75                  80  


Glu Arg Ala Asp Leu Trp Pro His Ser Asp Pro Tyr Trp Ala Ile Tyr 
                85                  90                  95      


Trp Pro Gly Gly Gln Ala Leu Ser Arg Tyr Leu Leu Asp Asn Pro Asp 
            100                 105                 110         


Val Val Arg Gly Lys Ser Val Leu Asp Leu Gly Ser Gly Cys Gly Ala 
        115                 120                 125             


Thr Ala Ile Ala Ala Lys Met Ser Gly Ala Ser Arg Ile Leu Ala Asn 
    130                 135                 140                 


Asp Ile Asp Pro Ile Ala Gly Met Ala Ile Thr Leu Asn Cys Glu Leu 
145                 150                 155                 160 


Asn Arg Leu Asn Pro Phe Pro Ile Leu Ile Gln Asn Ile Leu Asn Leu 
                165                 170                 175     


Glu Gln Asp Lys Trp Asp Leu Val Val Leu Gly Asp Met Phe Tyr Asp 
            180                 185                 190         


Glu Asp Leu Ala Asp Ser Leu His Gln Trp Leu Lys Lys Cys Phe Trp 
        195                 200                 205             


Thr Tyr Arg Thr Arg Val Leu Ile Gly Asp Pro Gly Arg Pro Gln Phe 
    210                 215                 220                 


Ser Gly His Ser Ile Gln His His Leu His Lys Val Val Glu Tyr Ser 
225                 230                 235                 240 


Leu Leu Glu Ser Thr Arg Gln Glu Asn Ser Gly Leu Thr Thr Ser Thr 
                245                 250                 255     


Val Trp Gly Phe Gln Pro 
            260         


<210> 7242
<211> 541
<212> PRT
<213> Homo sapiens

<400> 7242
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Gln Gly Ser Glu Asp Asn Leu Gln Gly 
        515                 520                 525             


Thr Asp Pro Pro Pro Val Gly Glu Glu Glu Val Leu Leu 
    530                 535                 540     


<210> 7243
<211> 100
<212> PRT
<213> Homo sapiens

<400> 7243
Met Ser Thr Ile Gly Ser Phe Glu Gly Phe Gln Ala Val Ser Leu Lys 
1               5                   10                  15      


Gln Glu Gly Asp Asp Gln Pro Ser Glu Thr Asp His Leu Ser Met Glu 
            20                  25                  30          


Glu Glu Asp Pro Met Pro Arg Gln Ile Ser Arg Gln Ser Ser Val Thr 
        35                  40                  45              


Glu Ser Thr Leu Tyr Pro Asn Pro Tyr His Gln Pro Tyr Ile Ser Arg 
    50                  55                  60                  


Lys Tyr Phe Ala Thr Arg Pro Gly Ala Ile Glu Thr Ala Met Glu Asp 
65                  70                  75                  80  


Leu Lys Gly His Val Ala Glu Thr Ser Gly Glu Thr Ile Gln Gly Phe 
                85                  90                  95      


Trp Leu Leu Thr 
            100 


<210> 7244
<211> 474
<212> PRT
<213> Homo sapiens

<400> 7244
Met Glu Arg Ser Gly Gln Arg Val Thr Thr Trp Asp Cys Asp Gln Gly 
1               5                   10                  15      


Lys His Ser Asp Ser Asp Tyr Arg Glu Asp Gly Met Asp Leu Gly Ser 
            20                  25                  30          


Asp Ala Gly Ser Ser Ser Ser Ser Ser Arg Ala Ser Ser Gln Ser Asn 
        35                  40                  45              


Ser Thr Lys Val Thr Pro Cys Ser Glu Cys Lys Ser Ser Ser Ser Pro 
    50                  55                  60                  


Gly Gly Ser Leu Asp Leu Val Ser Ala Leu Glu Asp Tyr Glu Glu Pro 
65                  70                  75                  80  


Phe Pro Val Tyr Gln Lys Lys Val Ile Asp Glu Trp Ala Pro Glu Glu 
                85                  90                  95      


Asp Gly Glu Glu Glu Glu Glu Glu Asp Glu Arg Asp Gln Arg Gly Tyr 
            100                 105                 110         


Arg Asp Asp Arg Ser Pro Ala Arg Glu Pro Gly Asp Val Ser Ala Arg 
        115                 120                 125             


Thr Arg Ser Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Met Pro 
    130                 135                 140                 


Pro Pro Val Pro Asn Gly Asn Leu His Gln His Asp Pro Gln Asp Leu 
145                 150                 155                 160 


Arg His Asn Gly Asn Val Val Val Ala Gly Arg Pro Ser Cys Ser Arg 
                165                 170                 175     


Gly Pro Arg Arg Ala Ile Gln Lys Pro Gln Pro Ala Gly Gly Arg Arg 
            180                 185                 190         


Ser Gly Arg Gly Pro Ala Ala Gly Gly Leu Cys Leu Gln Pro Pro Asp 
        195                 200                 205             


Gly Gly Thr Cys Val Pro Glu Glu Pro Pro Val Pro Pro Met Asp Trp 
    210                 215                 220                 


Glu Ala Leu Glu Lys His Leu Ala Gly Leu Gln Phe Arg Glu Gln Glu 
225                 230                 235                 240 


Ala Gln Lys Asn Glu Arg Glu Ser Ile Arg Gln Lys Leu Ala Leu Gly 
                245                 250                 255     


Ser Phe Phe Asp Asp Gly Pro Gly Ile Tyr Thr Ser Cys Ser Lys Ser 
            260                 265                 270         


Gly Lys Pro Ser Leu Ser Ser Arg Leu Gln Ser Gly Met Asn Leu Gln 
        275                 280                 285             


Ile Cys Phe Val Asn Asp Ser Gly Ser Asp Lys Asp Ser Asp Ala Asp 
    290                 295                 300                 


Asp Ser Lys Thr Glu Thr Ser Leu Asp Thr Pro Leu Ser Pro Met Ser 
305                 310                 315                 320 


Lys Gln Ser Ser Ser Tyr Ser Asp Arg Asp Thr Thr Glu Glu Glu Ser 
                325                 330                 335     


Glu Ser Leu Asp Asp Met Asp Phe Leu Thr Arg Gln Lys Lys Leu Gln 
            340                 345                 350         


Ala Glu Ala Lys Met Ala Leu Ala Met Ala Lys Pro Met Ala Lys Met 
        355                 360                 365             


Gln Val Glu Val Glu Lys Gln Asn Arg Lys Lys Ser Pro Val Ala Asp 
    370                 375                 380                 


Leu Leu Pro His Met Pro His Ile Ser Glu Cys Leu Met Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Pro Thr Asp Leu Arg Asp Met Thr Ile Gly Gln Leu Gln Val 
                405                 410                 415     


Ile Val Asn Asp Leu His Ser Gln Ile Glu Ser Leu Asn Glu Glu Leu 
            420                 425                 430         


Val Gln Leu Leu Leu Ile Arg Asp Glu Leu His Thr Glu Gln Asp Ala 
        435                 440                 445             


Met Leu Val Asp Ile Glu Asp Leu Thr Arg His Ala Glu Ser Gln Gln 
    450                 455                 460                 


Lys His Met Ala Glu Lys Met Pro Ala Lys 
465                 470                 


<210> 7245
<211> 229
<212> PRT
<213> Homo sapiens

<400> 7245
Met Gln Gln Arg Val Leu Glu Leu Ile Pro Gln Ile Ala Asn Glu Gln 
1               5                   10                  15      


Leu Thr Glu Glu Leu Leu Ile Val Asn Asp Asn Leu Asn Asn Val Phe 
            20                  25                  30          


Leu Arg His Glu Arg Phe Glu Arg Phe Arg Thr Gly Gln Thr Thr Lys 
        35                  40                  45              


Ala Pro Ser Glu Ala Glu Pro Ala Ala Asp Leu Ile Asp Met Gly Pro 
    50                  55                  60                  


Asp Pro Ala Ala Thr Gly Asn Leu Ser Ser Gln Leu Ala Gly Met Asn 
65                  70                  75                  80  


Leu Gly Ser Ser Ser Val Arg Ala Gly Leu Gln Ser Leu Glu Ala Ser 
                85                  90                  95      


Gly Arg Leu Glu Asp Glu Phe Asp Met Phe Ala Leu Thr Arg Gly Ser 
            100                 105                 110         


Ser Leu Ala Asp Gln Arg Lys Glu Val Lys Tyr Glu Ala Pro Gln Ala 
        115                 120                 125             


Thr Asp Gly Leu Ala Gly Ala Leu Asp Ala Arg Gln Gln Ser Thr Gly 
    130                 135                 140                 


Ala Ile Pro Val Thr Gln Ala Cys Leu Met Glu Asp Ile Glu Gln Trp 
145                 150                 155                 160 


Leu Ser Thr Asp Val Gly Asn Asp Ala Glu Glu Pro Lys Gly Val Thr 
                165                 170                 175     


Ser Glu Glu Phe Asp Lys Phe Leu Glu Glu Arg Ala Lys Ala Ala Asp 
            180                 185                 190         


Arg Leu Pro Asn Leu Ser Ser Pro Ser Ala Glu Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Ser Gly Pro Ala Pro Arg Lys Lys Thr Gln Glu Lys Asp Asp Asp 
    210                 215                 220                 


Met Leu Phe Ala Leu 
225                 


<210> 7246
<211> 549
<212> PRT
<213> Homo sapiens

<400> 7246
Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Leu Met 
65                  70                  75                  80  


Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val Glu Thr Lys Thr 
                85                  90                  95      


Asp Ala Lys Glu Glu Lys Ile Ile Arg Gly Ile Asp Lys Gly Arg Val 
            100                 105                 110         


Arg Ala Ala Val Asp Lys Lys Glu Ala Gly Lys Asp Gly Arg Gly Glu 
        115                 120                 125             


Glu Arg Ala Val Ala Thr Lys Lys Glu Glu Glu Lys Lys Gly Ser Asp 
    130                 135                 140                 


Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp Lys Lys Arg Glu Glu Met 
145                 150                 155                 160 


Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys Gly Glu Arg 
                165                 170                 175     


Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys Arg Ala Gly 
            180                 185                 190         


Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys Arg Gly Thr 
        195                 200                 205             


Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys Lys Asn Glu 
    210                 215                 220                 


Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr Lys Thr Pro 
225                 230                 235                 240 


Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu Gly Pro Ala 
                245                 250                 255     


Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu Pro Leu Glu 
            260                 265                 270         


Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn Val Asn Asn 
        275                 280                 285             


Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr Glu Ala Leu 
    290                 295                 300                 


Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn Thr Arg Ala 
305                 310                 315                 320 


Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys Ala Asn Lys 
                325                 330                 335     


Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr Gly Lys Gly 
            340                 345                 350         


Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr Leu Thr Glu 
        355                 360                 365             


Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys Thr Glu Met 
    370                 375                 380                 


Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Lys Leu Gly 
385                 390                 395                 400 


Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr Asn Leu Leu 
                405                 410                 415     


Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln Glu Gln Arg 
            420                 425                 430         


Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu Glu Val Pro 
        435                 440                 445             


Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser Pro Gln Pro 
    450                 455                 460                 


Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly Gly Ala Pro 
465                 470                 475                 480 


Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro Leu Ile Met 
                485                 490                 495     


Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg Lys Met Gly 
            500                 505                 510         


Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp Gln Leu Leu 
        515                 520                 525             


Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys Val Glu Val 
    530                 535                 540                 


Pro Lys Leu Leu Gln 
545                 


<210> 7247
<211> 76
<212> PRT
<213> Homo sapiens

<400> 7247
Met Ser Ala Ser Cys Asp Gly Cys Val Gly Ser Arg Pro Pro Val His 
1               5                   10                  15      


Leu Ala Ser Gly Tyr Ser Leu Ala Asp Leu Leu Val Leu Glu Met Gly 
            20                  25                  30          


Met Gly Thr Gln Cys Trp Thr Glu Asp Gln Arg Arg Trp Ser Ser Leu 
        35                  40                  45              


Trp Pro Trp Ser His Leu Ser Ser Asp Pro Ser Leu Pro Asn Val Gln 
    50                  55                  60                  


Val Thr Arg Leu Thr Leu Leu Ser Glu Gln Ala Pro 
65                  70                  75      


<210> 7248
<211> 471
<212> PRT
<213> Homo sapiens

<400> 7248
Met Ala Asn Ser Phe Ala Ala Arg Ile Phe Thr Thr Leu Ser Asp Leu 
1               5                   10                  15      


Gln Thr Asn Met Ala Asn Leu Lys Val Ile Gly Ile Val Ile Gly Lys 
            20                  25                  30          


Thr Asp Val Lys Gly Phe Pro Asp Arg Lys Asn Ile Gly Ser Glu Arg 
        35                  40                  45              


Tyr Thr Phe Ser Phe Thr Ile Arg Asp Ser Pro Ala His Phe Val Asn 
    50                  55                  60                  


Ala Ala Ser Trp Gly Asn Glu Asp Tyr Ile Lys Ser Leu Ser Asp Ser 
65                  70                  75                  80  


Phe Arg Val Gly Asp Cys Val Ile Ile Glu Asn Pro Leu Ile Gln Arg 
                85                  90                  95      


Lys Glu Ile Glu Arg Glu Glu Lys Phe Ser Pro Ala Thr Pro Ser Asn 
            100                 105                 110         


Cys Lys Leu Leu Leu Ser Glu Asn His Ser Thr Val Lys Val Cys Ser 
        115                 120                 125             


Ser Tyr Glu Val Asp Thr Lys Leu Leu Ser Leu Ile His Leu Pro Val 
    130                 135                 140                 


Lys Glu Ser His Asp Tyr Tyr Ser Leu Gly Asp Ile Val Ala Asn Gly 
145                 150                 155                 160 


His Ser Leu Asn Gly Arg Ile Ile Asn Val Leu Ala Ala Val Lys Ser 
                165                 170                 175     


Val Gly Glu Pro Lys Tyr Phe Thr Thr Ser Asp Arg Arg Lys Gly Gln 
            180                 185                 190         


Arg Cys Glu Val Arg Leu Tyr Asp Glu Thr Glu Ser Ser Phe Ala Met 
        195                 200                 205             


Thr Cys Trp Asp Asn Glu Ser Ile Leu Leu Ala Gln Ser Trp Met Pro 
    210                 215                 220                 


Arg Glu Thr Val Ile Phe Ala Ser Asp Val Arg Ile Asn Phe Asp Lys 
225                 230                 235                 240 


Phe Arg Asn Cys Met Thr Ala Thr Val Ile Ser Lys Thr Ile Ile Thr 
                245                 250                 255     


Thr Asn Pro Asp Ile Pro Glu Ala Asn Ile Leu Leu Asn Phe Ile Arg 
            260                 265                 270         


Glu Asn Lys Glu Thr Asn Val Leu Asp Asp Glu Ile Asp Ser Tyr Phe 
        275                 280                 285             


Lys Glu Ser Ile Asn Leu Ser Thr Ile Val Asp Val Tyr Thr Val Glu 
    290                 295                 300                 


Gln Leu Lys Gly Lys Ala Leu Lys Asn Glu Gly Lys Ala Asp Pro Ser 
305                 310                 315                 320 


Tyr Gly Ile Leu Tyr Ala Tyr Ile Ser Thr Leu Asn Ile Asp Asp Glu 
                325                 330                 335     


Thr Thr Lys Val Val Arg Asn Arg Cys Ser Ser Cys Gly Tyr Ile Val 
            340                 345                 350         


Asn Glu Ala Ser Asn Met Cys Thr Thr Cys Asn Lys Asn Ser Leu Asp 
        355                 360                 365             


Phe Lys Ser Val Phe Leu Ser Phe His Val Leu Ile Asp Leu Thr Asp 
    370                 375                 380                 


His Thr Gly Thr Leu His Ser Cys Ser Leu Thr Gly Ser Val Ala Glu 
385                 390                 395                 400 


Glu Thr Leu Gly Cys Thr Val His Glu Phe Leu Ala Met Thr Asp Glu 
                405                 410                 415     


Gln Lys Thr Ala Leu Lys Trp Gln Phe Leu Leu Glu Arg Ser Lys Ile 
            420                 425                 430         


Tyr Leu Lys Phe Val Leu Ser His Arg Ala Arg Ser Gly Leu Lys Ile 
        435                 440                 445             


Ser Val Leu Ser Cys Lys Leu Ala Asp Pro Thr Glu Ala Ser Arg Asn 
    450                 455                 460                 


Leu Ser Gly Gln Lys His Val 
465                 470     


<210> 7249
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7249
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 7250
<211> 881
<212> PRT
<213> Homo sapiens

<400> 7250
Met Phe Trp Lys Phe Asp Leu His Thr Ser Ser His Leu Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Leu Ser Leu Pro Glu Leu Leu Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Val Val Asn Arg Lys Leu Leu Asp Phe Leu 
        35                  40                  45              


Leu Gln Pro Pro His Leu Gln Ala Met Val Ala Trp Val Thr Gln Glu 
    50                  55                  60                  


Pro Pro Asp Ser Gly Glu Glu Arg Leu Arg Tyr Lys Tyr Pro Ser Val 
65                  70                  75                  80  


Ala Cys Glu Ile Leu Thr Ser Asp Val Pro Gln Ile Asn Asp Ala Leu 
                85                  90                  95      


Gly Ala Asp Glu Ser Leu Leu Asn Arg Leu Tyr Gly Phe Leu Gln Ser 
            100                 105                 110         


Thr Gly Ser Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Met 
        115                 120                 125             


Gly Ile Leu Ile Asn Arg Lys Thr Asp Gln Leu Val Ser Phe Leu Arg 
    130                 135                 140                 


Lys Lys Asp Asp Phe Val Asp Leu Leu Leu Gln His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Val Glu Arg Pro 
                165                 170                 175     


Gln Leu Arg Gln Asp Val Val Asn Trp Leu Asn Glu Glu Lys Ile Val 
            180                 185                 190         


Gln Arg Leu Ile Glu Gln Ile His Pro Ser Lys Asp Glu Asn Gln His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Asp Ile Ile Arg Leu Ser Arg Glu 
    210                 215                 220                 


Gln Met Ile Gln Val Gln Asp Ser Pro Glu Pro Asp Gln Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Thr Ile Glu Gln Leu Leu Ser Asn Met Phe 
                245                 250                 255     


Glu Gly Glu Gln Ser Gln Ser Val Ile Val Ser Gly Ile Gln Val Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Pro Arg Arg Pro Arg Ser Glu Ser Val Thr Val 
        275                 280                 285             


Asn Ser Phe Phe Ser Ser Val Asp Gly Gln Leu Glu Leu Leu Ala Gln 
    290                 295                 300                 


Gly Ala Leu Glu Ser Thr Val Ser Ser Val Gly Ala Leu His Ala Leu 
305                 310                 315                 320 


Arg Pro Arg Leu Ser Cys Phe His Gln Leu Leu Leu Glu Pro Pro Lys 
                325                 330                 335     


Leu Glu Pro Leu Gln Met Thr Trp Gly Met Leu Ala Pro Pro Leu Gly 
            340                 345                 350         


Asn Thr Arg Leu His Val Val Lys Leu Leu Ala Ser Ala Leu Ser Ala 
        355                 360                 365             


Asn Asp Ala Ala Leu Thr His Glu Leu Leu Ala Leu Asp Val Pro Asn 
    370                 375                 380                 


Thr Met Leu Asp Leu Phe Phe His Tyr Val Phe Asn Asn Phe Leu His 
385                 390                 395                 400 


Ala Gln Val Glu Gly Cys Val Ser Thr Met Leu Ser Leu Gly Pro Pro 
                405                 410                 415     


Pro Asp Ser Ser Pro Glu Thr Pro Ile Gln Asn Pro Val Val Lys His 
            420                 425                 430         


Leu Leu Gln Gln Cys Arg Leu Val Glu Arg Ile Leu Thr Ser Trp Glu 
        435                 440                 445             


Glu Asn Asp Arg Val Gln Cys Ala Gly Gly Pro Arg Lys Gly Tyr Met 
    450                 455                 460                 


Gly His Leu Thr Arg Val Ala Gly Ala Leu Val Gln Asn Thr Glu Lys 
465                 470                 475                 480 


Gly Pro Asn Ala Glu Gln Leu Arg Gln Leu Leu Lys Glu Leu Pro Ser 
                485                 490                 495     


Glu Gln Gln Glu Gln Trp Glu Ala Phe Val Ser Gly Pro Leu Ala Glu 
            500                 505                 510         


Thr Asn Lys Lys Asn Met Val Asp Leu Val Asn Thr His His Leu His 
        515                 520                 525             


Ser Ser Ser Asp Asp Glu Asp Asp Arg Leu Lys Glu Phe Asn Phe Pro 
    530                 535                 540                 


Glu Glu Ala Val Leu Gln Gln Ala Phe Met Asp Phe Gln Met Gln Arg 
545                 550                 555                 560 


Met Thr Ser Ala Phe Ile Asp His Phe Gly Phe Asn Asp Glu Glu Phe 
                565                 570                 575     


Gly Glu Gln Glu Glu Ser Val Asn Ala Pro Phe Asp Lys Thr Ala Asn 
            580                 585                 590         


Ile Thr Phe Ser Leu Asn Ala Asp Asp Glu Asn Pro Asn Ala Asn Leu 
        595                 600                 605             


Leu Glu Ile Cys Tyr Lys Asp Arg Ile Gln Gln Phe Asp Asp Asp Glu 
    610                 615                 620                 


Glu Glu Glu Asp Glu Glu Glu Ala Gln Gly Ser Gly Glu Ser Asp Gly 
625                 630                 635                 640 


Glu Asp Gly Ala Trp Gln Gly Ser Gln Leu Ala Arg Gly Ala Arg Leu 
                645                 650                 655     


Gly Gln Pro Pro Gly Val Arg Ser Gly Gly Ser Thr Asp Ser Glu Asp 
            660                 665                 670         


Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Gly Ile Gly 
        675                 680                 685             


Cys Ala Ala Arg Gly Gly Ala Thr Pro Leu Ser Tyr Pro Ser Pro Gly 
    690                 695                 700                 


Pro Gln Pro Pro Gly Pro Ser Trp Thr Ala Thr Phe Asp Pro Val Pro 
705                 710                 715                 720 


Thr Asp Ala Pro Thr Ser Pro Arg Val Ser Gly Glu Glu Glu Leu His 
                725                 730                 735     


Thr Gly Pro Pro Ala Pro Gln Gly Pro Leu Ser Val Pro Gln Gly Leu 
            740                 745                 750         


Pro Thr Gln Ser Leu Ala Ser Pro Pro Ala Arg Asp Ala Leu Gln Leu 
        755                 760                 765             


Arg Ser Gln Asp Pro Thr Pro Pro Ser Ala Pro Gln Glu Ala Thr Glu 
    770                 775                 780                 


Gly Ser Lys Val Thr Glu Pro Ser Ala Pro Cys Gln Ala Leu Val Ser 
785                 790                 795                 800 


Ile Gly Asp Leu Gln Ala Thr Phe His Gly Ile Arg Ser Ala Pro Ser 
                805                 810                 815     


Ser Ser Asp Ser Ala Thr Arg Asp Pro Ser Thr Ser Val Pro Ala Ser 
            820                 825                 830         


Gly Ala His Gln Pro Pro Gln Thr Thr Glu Gly Glu Lys Ser Pro Glu 
        835                 840                 845             


Pro Leu Gly Leu Pro Gln Ser Gln Ser Ala Gln Ala Leu Thr Pro Pro 
    850                 855                 860                 


Pro Ile Pro Asn Gly Ser Ala Pro Glu Gly Pro Ala Ser Pro Gly Ser 
865                 870                 875                 880 


Gln 
    


<210> 7251
<211> 117
<212> PRT
<213> Homo sapiens

<400> 7251
Met Lys Phe Gln Tyr Lys Glu Val His Pro Phe Glu Tyr Arg Lys Lys 
1               5                   10                  15      


Glu Gly Glu Lys Ile Arg Lys Lys Tyr Pro Asp Arg Val Pro Leu Ile 
            20                  25                  30          


Val Glu Lys Ala Pro Lys Ala Arg Val Pro Asp Leu Asp Arg Arg Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Leu Thr Asp Gly Gln Phe Tyr Leu Leu Ile 
    50                  55                  60                  


Arg Lys Arg Ile His Leu Arg Pro Glu Asp Ala Leu Phe Phe Phe Val 
65                  70                  75                  80  


Asn Asn Thr Ile Pro Pro Thr Ser Ala Thr Met Gly Gln Leu Tyr Glu 
                85                  90                  95      


Asp Ser His Glu Glu Asp Asp Phe Leu Tyr Val Ala Tyr Ser Asn Glu 
            100                 105                 110         


Ser Val Tyr Gly Lys 
        115         


<210> 7252
<211> 362
<212> PRT
<213> Homo sapiens

<400> 7252
Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Asn Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr Thr Pro Thr Tyr Gly Asp Leu Asn 
    130                 135                 140                 


His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu Arg Phe 
145                 150                 155                 160 


Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn Met Val 
                165                 170                 175     


Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro Leu Thr 
            180                 185                 190         


Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr 
        195                 200                 205             


Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp Pro Arg 
    210                 215                 220                 


His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg Met Ser 
225                 230                 235                 240 


Met Lys Glu Val Asp Glu Gln Met Leu Ser Val Gln Ser Lys Asn Ser 
                245                 250                 255     


Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala Val Cys 
            260                 265                 270         


Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Ala Thr Phe Ile Gly Asn 
        275                 280                 285             


Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln Phe Thr 
    290                 295                 300                 


Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Gly 
305                 310                 315                 320 


Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn Asp Leu 
                325                 330                 335     


Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu Gly Glu 
            340                 345                 350         


Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        355                 360         


<210> 7253
<211> 217
<212> PRT
<213> Homo sapiens

<400> 7253
Met Glu Glu Thr Met Lys Leu Ala Thr Met Glu Asp Thr Val Glu Tyr 
1               5                   10                  15      


Cys Leu Phe Leu Ile Pro Asp Glu Ser Arg Asp Ser Asp Lys His Lys 
            20                  25                  30          


Glu Ile Leu Gln Lys Tyr Ile Glu Arg Ile Ile Thr Arg Phe Ala Pro 
        35                  40                  45              


Met Leu Val Pro Tyr Ile Trp Gln Asn Gln Pro Phe Asn Leu Lys Tyr 
    50                  55                  60                  


Lys Pro Gly Lys Gly Gly Val Pro Ala His Met Phe Gly Val Thr Lys 
65                  70                  75                  80  


Phe Gly Asp Asn Ile Glu Asp Glu Trp Phe Ile Val Tyr Val Ile Lys 
                85                  90                  95      


Gln Ile Thr Lys Glu Phe Pro Glu Leu Val Ala Ser Thr Asn Arg Val 
            100                 105                 110         


Phe Phe Cys His Gly Glu Leu Cys Ile Ile Pro Ala Pro Arg Lys Ser 
        115                 120                 125             


Gly Ala Glu Ser Trp Leu Pro Thr Thr Pro Pro Thr Ile Pro Gln Ala 
    130                 135                 140                 


Leu Asn Ile Ile Thr Ala His Ser Glu Lys Ile Leu Ala Ser Glu Ser 
145                 150                 155                 160 


Ile Arg Ala Ala Val Asn Arg Arg Ile Arg Gly Tyr Pro Glu Lys Ile 
                165                 170                 175     


Gln Ala Ser Leu His Arg Ala His Cys Phe Leu Pro Ala Gly Ile Val 
            180                 185                 190         


Ala Val Leu Lys Gln Arg Pro Arg Leu Val Ala Ala Ala Val Gln Ala 
        195                 200                 205             


Phe Tyr Leu Arg Asp Pro Ile Asp Leu 
    210                 215         


<210> 7254
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7254
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210> 7255
<211> 33
<212> PRT
<213> Homo sapiens

<400> 7255
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His 
    


<210> 7256
<211> 413
<212> PRT
<213> Homo sapiens

<400> 7256
Met Phe Ala Ser Asp Leu Leu Arg Ala Leu Asp Cys Cys Pro Gly Ala 
1               5                   10                  15      


Gly Ser Ser Gly Leu Leu Pro Gln Leu Gly Pro Arg Gln Leu Leu Ala 
            20                  25                  30          


Phe Thr Val Asn Cys Leu Gly Asn His Arg Tyr Leu Gly Phe Phe Glu 
        35                  40                  45              


Asp Leu Glu Gln Arg His Lys Ala Gln Val Leu Val Glu Asp Ile Ser 
    50                  55                  60                  


Asp Ile Leu Glu Glu His Ala Glu Lys His Phe His Pro Tyr Ile Ala 
65                  70                  75                  80  


Tyr Cys Ser Asn Glu Val Tyr Gln Gln Arg Thr Leu Gln Lys Leu Ile 
                85                  90                  95      


Ser Ser Asn Ala Ala Phe Arg Glu Ala Leu Arg Glu Ile Glu Arg Arg 
            100                 105                 110         


Pro Ala Cys Gly Gly Leu Pro Met Leu Ser Phe Leu Ile Leu Pro Met 
        115                 120                 125             


Gln Arg Val Thr Arg Leu Pro Leu Leu Met Asp Thr Leu Cys Leu Lys 
    130                 135                 140                 


Thr Gln Gly His Ser Glu Arg Tyr Lys Ala Ala Ser Arg Ala Leu Lys 
145                 150                 155                 160 


Ala Ile Ser Lys Leu Val Arg Gln Cys Asn Glu Gly Ala His Arg Met 
                165                 170                 175     


Glu Arg Met Glu Gln Met Tyr Thr Leu His Thr Gln Leu Asp Phe Ser 
            180                 185                 190         


Lys Val Lys Ser Leu Pro Leu Ile Ser Ala Ser Arg Trp Leu Leu Lys 
        195                 200                 205             


Arg Gly Glu Leu Phe Leu Val Glu Glu Thr Gly Leu Phe Arg Lys Ile 
    210                 215                 220                 


Ala Ser Arg Pro Thr Cys Tyr Leu Phe Leu Phe Asn Asp Val Leu Val 
225                 230                 235                 240 


Val Thr Lys Lys Lys Ser Glu Glu Ser Tyr Met Val Gln Asp Tyr Ala 
                245                 250                 255     


Gln Met Asn His Ile Gln Val Glu Lys Ile Glu Pro Ser Glu Leu Pro 
            260                 265                 270         


Leu Pro Gly Gly Gly Asn Arg Ser Ser Ser Val Pro His Pro Phe Gln 
        275                 280                 285             


Val Thr Leu Leu Arg Asn Ser Glu Gly Arg Gln Glu Gln Leu Leu Leu 
    290                 295                 300                 


Ser Ser Asp Ser Ala Ser Asp Arg Ala Arg Trp Ile Val Ala Leu Thr 
305                 310                 315                 320 


His Ser Glu Arg Gln Trp Gln Gly Leu Ser Ser Lys Gly Asp Leu Pro 
                325                 330                 335     


Gln Val Glu Ile Thr Lys Ala Phe Phe Ala Lys Gln Ala Asp Glu Val 
            340                 345                 350         


Thr Leu Gln Gln Ala Asp Val Val Leu Val Leu Gln Gln Glu Asp Gly 
        355                 360                 365             


Trp Leu Tyr Gly Glu Arg Leu Arg Asp Gly Glu Thr Gly Trp Phe Pro 
    370                 375                 380                 


Glu Asp Phe Ala Arg Phe Ile Thr Ser Arg Val Ala Val Glu Gly Asn 
385                 390                 395                 400 


Val Arg Arg Met Glu Arg Leu Arg Val Glu Thr Asp Val 
                405                 410             


<210> 7257
<211> 629
<212> PRT
<213> Homo sapiens

<400> 7257
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Thr Tyr Ile Pro Asn Thr Lys Val Glu Cys 
            20                  25                  30          


His Tyr Thr Leu Pro Pro Gly Thr Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Thr Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Thr Thr Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Thr Ser Val Gln Phe Gln Ala Cys Asn Gln Leu Asp Glu Ser Gln Gln 
                85                  90                  95      


Glu Arg Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val 
            100                 105                 110         


Thr Glu Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Thr 
        115                 120                 125             


Ala Arg Gln Glu His Thr Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser 
    130                 135                 140                 


Arg Ser His Gly Glu Ile Thr Glu Glu Arg Asp Ile Leu Ser Arg Gln 
145                 150                 155                 160 


Gln Gly Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln 
                165                 170                 175     


Thr Ile Ser Glu Lys Val Leu Thr Lys Glu Val Glu Leu Asp Arg Leu 
            180                 185                 190         


Arg Asp Thr Val Lys Ala Leu Thr Arg Glu Gln Glu Lys Leu Leu Gly 
        195                 200                 205             


Gln Leu Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu 
    210                 215                 220                 


Gln Val Ala Gln Gln Glu Asn His His Leu Asn Leu Asp Leu Lys Glu 
225                 230                 235                 240 


Ala Lys Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln Arg Leu Lys 
                245                 250                 255     


Asp Lys Val Ala Gln Met Lys Asp Thr Leu Gly Gln Ala Gln Gln Arg 
            260                 265                 270         


Val Ala Glu Leu Glu Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu 
        275                 280                 285             


Leu Ala Ala Ser Ser Gln Gln Lys Ala Thr Leu Leu Gly Glu Glu Leu 
    290                 295                 300                 


Ala Ser Ala Ala Ala Ala Arg Asp Arg Thr Ile Ala Glu Leu His Arg 
305                 310                 315                 320 


Ser Arg Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly 
                325                 330                 335     


Leu His Leu Lys Glu Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly 
            340                 345                 350         


Leu Leu Gln Ser Val Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser 
        355                 360                 365             


Ala Glu Ile Leu Arg Leu Glu Lys Ala Val Gln Glu Glu Arg Thr Gln 
    370                 375                 380                 


Asn Gln Val Phe Lys Thr Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu 
385                 390                 395                 400 


Val Gln Leu Ser Glu Ser Lys Arg Glu Leu Thr Glu Leu Arg Ser Ala 
                405                 410                 415     


Leu Arg Val Leu Gln Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln 
            420                 425                 430         


Glu Leu Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val 
        435                 440                 445             


Ala Asp Glu Lys Trp Asn Glu Asp Ala Thr Thr Glu Asp Glu Glu Ala 
    450                 455                 460                 


Ala Val Gly Leu Ser Cys Pro Ala Ala Leu Thr Asp Ser Glu Asp Glu 
465                 470                 475                 480 


Ser Pro Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly 
                485                 490                 495     


Asp Pro Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val 
            500                 505                 510         


Val Ile Ser Gln Pro Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala 
        515                 520                 525             


Glu Asp Ser Ser Ser Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu 
    530                 535                 540                 


Met Ala Ala Val Gln Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro 
545                 550                 555                 560 


Glu Leu Gly Ser Ala Phe Tyr Asp Met Ala Ser Gly Phe Thr Val Gly 
                565                 570                 575     


Thr Leu Ser Glu Thr Ser Thr Gly Gly Pro Ala Thr Pro Thr Trp Lys 
            580                 585                 590         


Glu Cys Pro Ile Cys Lys Glu Arg Phe Pro Ala Glu Ser Asp Lys Asp 
        595                 600                 605             


Ala Leu Glu Asp His Met Asp Gly His Phe Phe Phe Ser Thr Gln Asp 
    610                 615                 620                 


Pro Phe Thr Phe Glu 
625                 


<210> 7258
<211> 816
<212> PRT
<213> Homo sapiens

<400> 7258
Met Pro Leu Ser Ser Pro Asn Ala Ala Ala Thr Ala Ser Asp Met Asp 
1               5                   10                  15      


Lys Asn Ser Gly Ser Asn Ser Ser Ser Ala Ser Ser Gly Ser Ser Lys 
            20                  25                  30          


Gly Gln Gln Pro Pro Arg Ser Ala Ser Ala Gly Pro Ala Gly Glu Ser 
        35                  40                  45              


Lys Pro Lys Ser Asp Gly Lys Asn Ser Ser Gly Ser Lys Arg Tyr Asn 
    50                  55                  60                  


Arg Lys Arg Glu Leu Ser Tyr Pro Lys Asn Glu Ser Phe Asn Asn Gln 
65                  70                  75                  80  


Ser Arg Arg Ser Ser Ser Gln Lys Ser Lys Thr Phe Asn Lys Met Pro 
                85                  90                  95      


Pro Gln Arg Gly Gly Gly Ser Ser Lys Leu Phe Ser Ser Ser Phe Asn 
            100                 105                 110         


Gly Gly Arg Arg Asp Glu Val Ala Glu Ala Gln Arg Ala Glu Phe Ser 
        115                 120                 125             


Pro Ala Gln Phe Ser Gly Pro Lys Lys Ile Asn Leu Asn His Leu Leu 
    130                 135                 140                 


Asn Phe Thr Phe Glu Pro Arg Gly Gln Thr Gly His Phe Glu Gly Ser 
145                 150                 155                 160 


Gly His Gly Ser Trp Gly Lys Arg Asn Lys Trp Gly His Lys Pro Phe 
                165                 170                 175     


Asn Lys Glu Leu Phe Leu Gln Ala Asn Cys Gln Phe Val Val Ser Glu 
            180                 185                 190         


Asp Gln Asp Tyr Thr Ala His Phe Ala Asp Pro Asp Thr Leu Val Asn 
        195                 200                 205             


Trp Asp Phe Val Glu Gln Val Arg Ile Cys Ser His Glu Val Pro Ser 
    210                 215                 220                 


Cys Pro Ile Cys Leu Tyr Pro Pro Thr Ala Ala Lys Ile Thr Arg Cys 
225                 230                 235                 240 


Gly His Ile Phe Cys Trp Ala Cys Ile Leu His Tyr Leu Ser Leu Ser 
                245                 250                 255     


Glu Lys Thr Trp Ser Lys Cys Pro Ile Cys Tyr Ser Ser Val His Lys 
            260                 265                 270         


Lys Asp Leu Lys Ser Val Val Ala Thr Glu Ser His Gln Tyr Val Val 
        275                 280                 285             


Gly Asp Thr Ile Thr Met Gln Leu Met Lys Arg Glu Lys Gly Val Leu 
    290                 295                 300                 


Val Ala Leu Pro Lys Ser Lys Trp Met Asn Val Asp His Pro Ile His 
305                 310                 315                 320 


Leu Gly Asp Glu Gln His Ser Gln Tyr Ser Lys Leu Leu Leu Ala Ser 
                325                 330                 335     


Lys Glu Gln Val Leu His Arg Val Val Leu Glu Glu Lys Val Ala Leu 
            340                 345                 350         


Glu Gln Gln Leu Ala Glu Glu Lys His Thr Pro Glu Ser Cys Phe Ile 
        355                 360                 365             


Glu Ala Ala Ile Gln Glu Leu Lys Thr Arg Glu Glu Ala Leu Ser Gly 
    370                 375                 380                 


Leu Ala Gly Ser Arg Arg Glu Val Thr Gly Val Val Ala Ala Leu Glu 
385                 390                 395                 400 


Gln Leu Val Leu Met Ala Pro Leu Ala Lys Glu Ser Val Phe Gln Pro 
                405                 410                 415     


Arg Lys Ser Leu Leu Gln Gln Gly Val Leu Glu Tyr Leu Ser Ala Phe 
            420                 425                 430         


Asp Glu Glu Thr Thr Glu Val Cys Ser Leu Asp Thr Pro Ser Arg Pro 
        435                 440                 445             


Leu Ala Leu Pro Leu Val Glu Glu Glu Glu Ala Val Ser Glu Pro Glu 
    450                 455                 460                 


Pro Glu Gly Leu Pro Glu Ala Cys Asp Asp Leu Glu Leu Ala Asp Asp 
465                 470                 475                 480 


Asn Leu Lys Glu Gly Thr Ile Cys Thr Glu Ser Ser Gln Gln Glu Pro 
                485                 490                 495     


Ile Thr Lys Ser Gly Phe Thr Arg Leu Ser Ser Ser Pro Cys Tyr Tyr 
            500                 505                 510         


Phe Tyr Gln Ala Glu Asp Gly Gln His Met Phe Leu His Pro Val Asn 
        515                 520                 525             


Val Arg Cys Leu Val Arg Glu Tyr Gly Ser Leu Glu Arg Ser Pro Glu 
    530                 535                 540                 


Lys Ile Ser Ala Thr Val Val Glu Ile Ala Gly Tyr Ser Met Ser Glu 
545                 550                 555                 560 


Asp Val Arg Gln Arg His Arg Tyr Leu Ser His Leu Pro Leu Thr Cys 
                565                 570                 575     


Glu Phe Ser Ile Cys Glu Leu Ala Leu Gln Pro Pro Val Val Ser Lys 
            580                 585                 590         


Glu Thr Leu Glu Met Phe Ser Asp Asp Ile Glu Lys Arg Lys Arg Gln 
        595                 600                 605             


Arg Gln Lys Lys Ala Arg Glu Glu Arg Arg Arg Glu Arg Arg Ile Glu 
    610                 615                 620                 


Ile Glu Glu Asn Lys Lys Gln Gly Lys Tyr Pro Glu Val His Ile Pro 
625                 630                 635                 640 


Leu Glu Asn Leu Gln Gln Phe Pro Ala Phe Asn Ser Tyr Thr Cys Ser 
                645                 650                 655     


Ser Asp Ser Ala Leu Gly Pro Thr Ser Thr Glu Gly His Gly Ala Leu 
            660                 665                 670         


Ser Ile Ser Pro Leu Ser Arg Ser Pro Gly Ser His Ala Asp Phe Leu 
        675                 680                 685             


Leu Thr Pro Leu Ser Pro Thr Ala Ser Gln Gly Ser Pro Ser Phe Cys 
    690                 695                 700                 


Val Gly Ser Leu Glu Glu Asp Ser Pro Phe Pro Ser Phe Ala Gln Met 
705                 710                 715                 720 


Leu Arg Val Gly Lys Ala Lys Ala Asp Val Trp Pro Lys Thr Ala Pro 
                725                 730                 735     


Lys Lys Asp Glu Asn Ser Leu Val Pro Pro Ala Pro Val Asp Ser Asp 
            740                 745                 750         


Gly Glu Ser Asp Asn Ser Asp Arg Val Pro Val Pro Ser Phe Gln Asn 
        755                 760                 765             


Ser Phe Ser Gln Ala Ile Glu Ala Ala Phe Met Lys Leu Asp Thr Pro 
    770                 775                 780                 


Ala Thr Ser Asp Pro Leu Ser Glu Glu Lys Gly Gly Lys Lys Arg Lys 
785                 790                 795                 800 


Lys Gln Lys Gln Lys Leu Leu Phe Ser Thr Ser Val Val His Thr Lys 
                805                 810                 815     


<210> 7259
<211> 142
<212> PRT
<213> Homo sapiens

<400> 7259
Met Ala Ser Pro Gly Lys Asp Asn Tyr Arg Met Lys Ser Tyr Lys Asn 
1               5                   10                  15      


Lys Ala Leu Asn Pro Gln Glu Met Arg Arg Arg Arg Glu Glu Glu Gly 
            20                  25                  30          


Ile Gln Leu Arg Lys Gln Lys Arg Glu Glu Gln Leu Phe Lys Arg Arg 
        35                  40                  45              


Asn Val Tyr Leu Pro Arg Asn Asp Glu Ser Met Leu Glu Ser Pro Ile 
    50                  55                  60                  


Gln Asp Pro Asp Ile Ser Ser Thr Val Pro Ile Pro Glu Glu Glu Val 
65                  70                  75                  80  


Val Thr Thr Asp Met Val Gln Met Ile Phe Ser Asn Asn Ala Asp Gln 
                85                  90                  95      


Gln Leu Thr Ala Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys Glu Pro 
            100                 105                 110         


Asn Pro Pro Ile Asp Gln Val Ile Gln Lys Pro Gly Val Val Gln Arg 
        115                 120                 125             


Phe Val Lys Phe Leu Glu Arg Asn Glu Asn Cys Thr Leu Gln 
    130                 135                 140         


<210> 7260
<211> 98
<212> PRT
<213> Homo sapiens

<400> 7260
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Glu Ser Ile His Leu Gln Leu Ser Ser 
                85                  90                  95      


Phe Ser 
        


<210> 7261
<211> 638
<212> PRT
<213> Homo sapiens

<400> 7261
Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys 
1               5                   10                  15      


Lys Leu Asn Gly Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met 
            20                  25                  30          


Ile Thr Asp Ile His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr 
        35                  40                  45              


Val Lys Lys Glu His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr 
    50                  55                  60                  


Asp Gly Glu His Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu 
65                  70                  75                  80  


His Leu Asn Pro Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser 
                85                  90                  95      


Ser Gln Ser Ser Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser 
            100                 105                 110         


Gln Glu Ser Met Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln 
        115                 120                 125             


Val Leu Pro Gly Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu 
    130                 135                 140                 


Thr Gln Thr Val Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly 
145                 150                 155                 160 


Gly Glu Lys Arg Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg 
                165                 170                 175     


Glu Phe Thr Leu Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile 
            180                 185                 190         


Tyr Cys Ser Arg Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu 
        195                 200                 205             


Gly Ile Leu Pro Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr 
    210                 215                 220                 


Asp Ala Gln Arg Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro 
225                 230                 235                 240 


Gln Asn Gly Ser Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys 
                245                 250                 255     


Glu Thr Gly Ser Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys 
            260                 265                 270         


Gln Gly Leu Phe Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys 
        275                 280                 285             


Ile Gln Cys Leu Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val 
    290                 295                 300                 


Met His Ser His Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe 
305                 310                 315                 320 


Glu Ser Ala Lys Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu 
                325                 330                 335     


Gly Thr Pro Glu Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys 
            340                 345                 350         


Glu Lys Phe Ser Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp 
        355                 360                 365             


Ala Pro Ser Gly Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln 
    370                 375                 380                 


Glu Gly Asp His Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr 
385                 390                 395                 400 


Tyr Leu Tyr Met Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr 
                405                 410                 415     


Ser Ala Val Ser Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Asn Ala 
            420                 425                 430         


Ser Ile Ser Asn Asn Ser Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr 
        435                 440                 445             


Cys Asn Leu Val Arg Asp Ile Asn Lys Val Gly Ile Gly Leu Val Ala 
    450                 455                 460                 


Ala Ala Ser Ser Pro Leu Leu Val Lys Asp Val Ile Cys Glu Asp Asp 
465                 470                 475                 480 


Lys Gly Lys Ile Met Glu Glu Val Met Arg Thr Tyr Leu Lys Gln Gln 
                485                 490                 495     


Glu Lys Leu Asn Leu Ile Leu Gln Lys Lys Gln Gln Leu Gln Met Glu 
            500                 505                 510         


Val Lys Met Leu Ser Ser Ser Lys Ser Met Lys Glu Leu Thr Glu Glu 
        515                 520                 525             


Gln Gln Asn Leu Gln Lys Glu Leu Glu Ser Leu Gln Asn Glu His Ala 
    530                 535                 540                 


Gln Arg Met Glu Glu Phe Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys 
545                 550                 555                 560 


Leu Glu Gln Ile Met Lys Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu 
                565                 570                 575     


Lys Asp Lys Glu Ala Glu Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln 
            580                 585                 590         


Arg Leu Asp His Ala Glu Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu 
        595                 600                 605             


Arg Gln Glu Arg Glu Ala Arg Gln Lys Leu Glu Met Met Ile Lys Glu 
    610                 615                 620                 


Leu Lys Leu Gln Ile Leu Lys Ser Ser Lys Thr Ala Lys Glu 
625                 630                 635             


<210> 7262
<211> 509
<212> PRT
<213> Homo sapiens

<400> 7262
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg Tyr Asp Leu Asn 
    130                 135                 140                 


Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu Glu Phe Lys Glu 
145                 150                 155                 160 


Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu Arg Val Leu Glu 
                165                 170                 175     


Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His Ala Ile Glu Thr 
            180                 185                 190         


Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val Val Cys Asp Val 
        195                 200                 205             


Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met Val Phe Cys Asp 
    210                 215                 220                 


Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val 
225                 230                 235                 240 


Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu Gly Val Gln Pro 
                245                 250                 255     


Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met Lys Pro Thr Arg 
            260                 265                 270         


Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu Trp Ile Pro Glu 
        275                 280                 285             


Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile Thr Lys Val Ser 
    290                 295                 300                 


His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser Leu Cys Asn Glu 
305                 310                 315                 320 


Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn Cys Arg Thr Ala 
                325                 330                 335     


Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu Met Lys Thr Ile 
            340                 345                 350         


Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr Cys Pro Lys His 
        355                 360                 365             


Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys Gly Ala Ala Gln 
    370                 375                 380                 


Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro Leu Glu Pro Phe 
385                 390                 395                 400 


Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg Val Ser Val Arg 
                405                 410                 415     


Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr Thr Phe Val Asn 
            420                 425                 430         


Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu Glu Val Val Asp 
        435                 440                 445             


Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val Asn Phe Asn Lys 
    450                 455                 460                 


Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn Leu Ala Lys Arg 
465                 470                 475                 480 


Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe Thr His Leu Arg 
                485                 490                 495     


Gln Asp Leu Glu Arg Val Met Ile Asp Thr Asp Thr Leu 
            500                 505                 


<210> 7263
<211> 117
<212> PRT
<213> Homo sapiens

<400> 7263
Met Ala Phe Ser Gly Arg Ala Arg Pro Cys Ile Ile Pro Glu Asn Glu 
1               5                   10                  15      


Glu Ile Pro Arg Ala Ala Leu Asn Thr Val His Glu Ala Asn Gly Thr 
            20                  25                  30          


Glu Asp Glu Arg Ala Val Ser Lys Leu Gln Arg Arg His Ser Asp Val 
        35                  40                  45              


Lys Val Tyr Lys Glu Phe Cys Asp Phe Tyr Ala Lys Phe Asn Met Ala 
    50                  55                  60                  


Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly Phe Ala 
65                  70                  75                  80  


Pro Ala Glu Thr Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu Gln 
                85                  90                  95      


Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly Leu Phe 
            100                 105                 110         


Tyr Glu Glu Arg Thr 
        115         


<210> 7264
<211> 369
<212> PRT
<213> Homo sapiens

<400> 7264
Met Lys Asp Thr Gln Asp Ile Gln Glu Ala Ser Lys Ala Met Gln Asn 
1               5                   10                  15      


Lys Val His Glu Gln Glu Asp Lys Asn Glu Lys Gln Lys Gln Arg Glu 
            20                  25                  30          


Asp Lys Leu Gly Val Tyr Ser Leu Val His Phe Ser Pro Lys Met Leu 
        35                  40                  45              


Gly Ser Val Ala Thr Thr Leu Pro Leu Ser Ser Ser Asn Ser Ser Gly 
    50                  55                  60                  


Met Pro Leu Gly Tyr Tyr Leu Ser Ser Pro Gln Ile Ser Arg Val Thr 
65                  70                  75                  80  


Ile Ser Thr Thr Gly Gln Leu Thr Ser Lys Ala Thr Val Gly Ser Cys 
                85                  90                  95      


Ser Arg Val Glu Asn Ser Leu Asp Ala Ser Pro Phe Ser Val Pro Lys 
            100                 105                 110         


Lys Gln Asp Glu Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu 
        115                 120                 125             


Ser Leu Phe Gly Asp Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr 
    130                 135                 140                 


Gln Lys Thr Leu Lys Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln 
145                 150                 155                 160 


Phe Thr Ser Ser Ser Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val 
                165                 170                 175     


Lys Gly Leu Phe Val Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met 
            180                 185                 190         


Ala Ile Gly Asp His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile 
        195                 200                 205             


Ser Leu Tyr Arg Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr 
    210                 215                 220                 


Val Thr Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys Gln Ala Trp 
225                 230                 235                 240 


Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser Val Val Ser 
                245                 250                 255     


Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser Thr Ala Thr 
            260                 265                 270         


Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile Ser Asn Tyr 
        275                 280                 285             


Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys Glu Ile Pro 
    290                 295                 300                 


Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn Pro Tyr Val 
305                 310                 315                 320 


Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn Thr Ser Thr 
                325                 330                 335     


Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser Thr Arg Pro 
            340                 345                 350         


Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu Ser Gln Lys 
        355                 360                 365             


Gln 
    


<210> 7265
<211> 226
<212> PRT
<213> Homo sapiens

<400> 7265
Met Asp Gln Ser Arg Val Leu Leu Trp Val Lys Ala Glu Pro Phe Ile 
1               5                   10                  15      


Val Gly Ala Leu Gln Val Pro Pro Pro Ser Lys Phe Ser Leu His Tyr 
            20                  25                  30          


Leu Arg Lys Ile Ser Thr Tyr Val Gln Ile Arg Ala Thr Glu Gly Ala 
        35                  40                  45              


Tyr Pro Arg Leu Tyr Trp Ser Thr Trp Arg His Ile Ala Cys Gly Lys 
    50                  55                  60                  


Leu Gln Leu Ala Lys Asp Leu Ala Trp Leu Tyr Phe Glu Ile Phe Asp 
65                  70                  75                  80  


Ser Leu Ser Met Lys Thr Pro Glu Glu Arg Leu Glu Trp Ser Glu Val 
                85                  90                  95      


Leu Ser Asn Cys Met Ser Glu Glu Glu Val Glu Lys Gln Arg Asn Gln 
            100                 105                 110         


Leu Ser Val Asp Thr Leu Gln Phe Leu Leu Phe Leu Tyr Ile Gln Gln 
        115                 120                 125             


Leu Asn Lys Val Ser Leu Arg Thr Ser Leu Ile Gly Glu Glu Trp Pro 
    130                 135                 140                 


Ser Pro Arg Asn Lys Ser Gln Ser Pro Asp Leu Thr Glu Lys Ser Asn 
145                 150                 155                 160 


Cys His Asn Lys Asn Trp Asn Asp Tyr Ser His Gln Ala Phe Val Tyr 
                165                 170                 175     


Asp His Leu Ser Asp Leu Leu Glu Leu Leu Leu Asp Pro Lys Gln Leu 
            180                 185                 190         


Thr Ala Ser Phe His Ser Thr His Ser Ser Leu Val Ser Arg Glu Ala 
        195                 200                 205             


Val Val Ala Leu Ser Phe Leu Ile Glu Gly Thr Ile Ser Arg Ala Arg 
    210                 215                 220                 


Lys Ile 
225     


<210> 7266
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7266
Met Asn Asp Arg Leu Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr 
1               5                   10                  15      


Ser Phe Leu Leu Asn Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe 
            20                  25                  30          


Phe Ser Lys Val Leu Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile 
        35                  40                  45              


Val Asp Phe Leu Lys Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys 
    50                  55                  60                  


His Ile Gly Thr Ser Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr 
65                  70                  75                  80  


Cys Ile Glu Pro Pro Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn 
                85                  90                  95      


Glu Glu Lys Ile Ile Gln Arg Leu Val Glu Ile Val His Pro Ser Gln 
            100                 105                 110         


Glu Glu Asp Arg His Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val 
        115                 120                 125             


Arg Leu Ser Arg Asp Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro 
    130                 135                 140                 


Asp Leu Leu Leu Ala Ser Gly Leu Pro Asp Leu Asn Gly Val Gly Pro 
145                 150                 155                 160 


Arg Gly Leu Leu Val Asp Asn Met Leu Trp Ser Arg Leu Val Val Ser 
                165                 170                 175     


Phe Ala Ser His Gly Gln Gly Leu Ala Pro Leu Val Ala His Val Ala 
            180                 185                 190         


Ser Val Val Trp Thr Trp Trp Leu Leu His Pro Thr Val Ala Ser Val 
        195                 200                 205             


Val Trp Thr Trp Trp Leu Leu His Pro Thr Gln Gly Asn Ser Val Leu 
    210                 215                 220                 


Leu His Pro Thr Asp Cys Trp Glu Arg Ala Ser Gly Thr Phe Leu Trp 
225                 230                 235                 240 


Gly Ile Ile Leu Phe Cys Leu Ser 
                245             


<210> 7267
<211> 622
<212> PRT
<213> Homo sapiens

<400> 7267
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 
            100                 105                 110         


Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 
        115                 120                 125             


Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 
    130                 135                 140                 


Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 
145                 150                 155                 160 


Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 
                165                 170                 175     


Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 
            180                 185                 190         


Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 
        195                 200                 205             


Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 
    210                 215                 220                 


Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 
225                 230                 235                 240 


His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 
                245                 250                 255     


Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 
            260                 265                 270         


Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 
        275                 280                 285             


Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 
    290                 295                 300                 


Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 
305                 310                 315                 320 


Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 
                325                 330                 335     


Gly Met Thr Ser Val Leu Met Ser Ala Ile Gly Leu Pro Val Cys Leu 
            340                 345                 350         


Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro Ala Ser Arg Leu Ala Ser 
        355                 360                 365             


Lys Ser His Gly Ser Val Lys Arg Leu Arg Lys Met Ser Val Lys Gly 
    370                 375                 380                 


Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn Tyr 
385                 390                 395                 400 


Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys Met 
                405                 410                 415     


Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser Lys 
            420                 425                 430         


Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His Ala 
        435                 440                 445             


Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys Asp 
    450                 455                 460                 


Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys Thr 
465                 470                 475                 480 


Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met Ser 
                485                 490                 495     


Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser Ile 
            500                 505                 510         


Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro Phe 
        515                 520                 525             


Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala Gln 
    530                 535                 540                 


Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg Leu 
545                 550                 555                 560 


Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr Val 
                565                 570                 575     


Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile Thr 
            580                 585                 590         


Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala Glu 
        595                 600                 605             


Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 
    610                 615                 620         


<210> 7268
<211> 1335
<212> PRT
<213> Homo sapiens

<400> 7268
Met Glu Glu Ile Pro Val Lys Val Ala Val Arg Ile Arg Pro Leu Leu 
1               5                   10                  15      


Cys Lys Glu Ala Leu His Asn His Gln Val Cys Val Arg Val Ile Pro 
            20                  25                  30          


Asn Ser Gln Gln Val Ile Ile Gly Arg Asp Arg Val Phe Thr Phe Asp 
        35                  40                  45              


Phe Val Phe Gly Lys Asn Ser Thr Gln Asp Glu Val Tyr Asn Thr Cys 
    50                  55                  60                  


Ile Lys Pro Leu Val Leu Ser Leu Ile Glu Gly Tyr Asn Ala Thr Val 
65                  70                  75                  80  


Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr Tyr Thr Ile Gly Gly 
                85                  90                  95      


Gly His Ile Ala Ser Val Val Glu Gly Gln Lys Gly Ile Ile Pro Arg 
            100                 105                 110         


Ala Ile Gln Glu Ile Phe Gln Ser Ile Ser Glu His Pro Ser Ile Asp 
        115                 120                 125             


Phe Asn Val Lys Val Ser Tyr Ile Glu Val Tyr Lys Glu Asp Leu Arg 
    130                 135                 140                 


Asp Leu Leu Glu Leu Glu Thr Ser Met Lys Asp Leu His Ile Arg Glu 
145                 150                 155                 160 


Asp Glu Lys Gly Asn Thr Val Ile Val Gly Ala Lys Glu Cys His Val 
                165                 170                 175     


Glu Ser Ala Gly Glu Val Met Ser Leu Leu Glu Met Gly Asn Ala Ala 
            180                 185                 190         


Arg His Thr Gly Thr Thr Gln Met Asn Glu His Ser Ser Arg Ser His 
        195                 200                 205             


Ala Ile Phe Thr Ile Ser Ile Cys Gln Val His Lys Asn Met Glu Ala 
    210                 215                 220                 


Ala Glu Asp Gly Ser Trp Tyr Ser Pro Arg His Ile Val Ser Lys Phe 
225                 230                 235                 240 


His Phe Val Asp Leu Ala Gly Ser Glu Arg Val Thr Lys Thr Gly Asn 
                245                 250                 255     


Thr Gly Glu Arg Phe Lys Glu Ser Ile Gln Ile Asn Ser Gly Leu Leu 
            260                 265                 270         


Ala Leu Gly Asn Val Ile Ser Ala Leu Gly Asp Pro Arg Arg Lys Ser 
        275                 280                 285             


Ser His Ile Pro Tyr Arg Asp Ala Lys Ile Thr Arg Leu Leu Lys Asp 
    290                 295                 300                 


Ser Leu Gly Gly Ser Ala Lys Thr Val Met Ile Thr Cys Val Ser Pro 
305                 310                 315                 320 


Ser Ser Ser Asn Phe Asp Glu Ser Leu Asn Ser Leu Lys Tyr Ala Asn 
                325                 330                 335     


Arg Ala Arg Asn Ile Arg Asn Lys Pro Thr Val Asn Phe Ser Pro Glu 
            340                 345                 350         


Ser Asp Arg Ile Asp Glu Met Glu Phe Glu Ile Lys Leu Leu Arg Glu 
        355                 360                 365             


Ala Leu Gln Ser Gln Gln Ala Gly Val Ser Gln Thr Thr Gln Ile Asn 
    370                 375                 380                 


Arg Glu Gly Ser Pro Asp Thr Asn Arg Ile His Ser Leu Glu Glu Gln 
385                 390                 395                 400 


Val Ala Gln Leu Gln Gly Glu Cys Leu Gly Tyr Gln Cys Cys Val Glu 
                405                 410                 415     


Glu Ala Phe Thr Phe Leu Val Asp Leu Lys Asp Thr Val Arg Leu Asn 
            420                 425                 430         


Glu Lys Gln Gln His Lys Leu Gln Glu Trp Phe Asn Met Ile Gln Glu 
        435                 440                 445             


Val Arg Lys Ala Val Leu Thr Ser Phe Arg Gly Ile Gly Gly Thr Ala 
    450                 455                 460                 


Ser Leu Glu Glu Gly Pro Gln His Val Thr Val Leu Gln Leu Lys Arg 
465                 470                 475                 480 


Glu Leu Lys Lys Cys Gln Cys Val Leu Ala Ala Asp Glu Val Val Phe 
                485                 490                 495     


Asn Gln Lys Glu Leu Glu Val Lys Glu Leu Lys Asn Gln Val Gln Met 
            500                 505                 510         


Met Val Gln Glu Asn Lys Gly His Ala Val Ser Leu Lys Glu Ala Gln 
        515                 520                 525             


Lys Val Asn Arg Leu Gln Asn Glu Lys Ile Ile Glu Gln Gln Leu Leu 
    530                 535                 540                 


Val Asp Gln Leu Ser Glu Glu Leu Thr Lys Leu Asn Leu Ser Val Thr 
545                 550                 555                 560 


Ser Ser Ala Lys Glu Asn Cys Gly Asp Gly Pro Asp Ala Arg Ile Pro 
                565                 570                 575     


Glu Arg Arg Pro Tyr Thr Val Pro Phe Asp Thr His Leu Gly His Tyr 
            580                 585                 590         


Ile Tyr Ile Pro Ser Arg Gln Asp Ser Arg Lys Val His Thr Ser Pro 
        595                 600                 605             


Pro Met Tyr Ser Leu Asp Arg Ile Phe Ala Gly Phe Arg Thr Arg Ser 
    610                 615                 620                 


Gln Met Leu Leu Gly His Ile Glu Glu Gln Asp Lys Val Leu His Cys 
625                 630                 635                 640 


Gln Phe Ser Asp Asn Ser Asp Asp Glu Glu Ser Glu Gly Gln Glu Lys 
                645                 650                 655     


Ser Gly Thr Arg Cys Arg Ser Arg Ser Trp Ile Gln Lys Pro Asp Ser 
            660                 665                 670         


Val Cys Ser Leu Val Glu Leu Ser Asp Thr Gln Asp Glu Thr Gln Lys 
        675                 680                 685             


Ser Asp Leu Glu Asn Glu Asp Leu Lys Ile Asp Cys Leu Gln Glu Ser 
    690                 695                 700                 


Gln Glu Leu Asn Leu Gln Lys Leu Lys Asn Ser Glu Arg Ile Leu Thr 
705                 710                 715                 720 


Glu Ala Lys Gln Lys Met Arg Glu Leu Thr Ile Asn Ile Lys Met Lys 
                725                 730                 735     


Glu Asp Leu Ile Lys Glu Leu Ile Lys Thr Gly Asn Asp Ala Lys Ser 
            740                 745                 750         


Val Ser Lys Gln Tyr Ser Leu Lys Val Thr Lys Leu Glu His Asp Ala 
        755                 760                 765             


Glu Gln Ala Lys Val Glu Leu Ile Glu Thr Gln Lys Gln Leu Gln Glu 
    770                 775                 780                 


Leu Glu Asn Lys Asp Leu Ser Asp Val Ala Met Lys Val Lys Leu Gln 
785                 790                 795                 800 


Lys Glu Phe Arg Lys Lys Met Asp Ala Ala Lys Leu Arg Val Gln Glu 
                805                 810                 815     


Ile Gln Leu Lys Thr Gly Gln Glu Glu Gly Leu Lys Pro Lys Ala Glu 
            820                 825                 830         


Asp Leu Asp Ala Cys Asn Leu Lys Arg Arg Lys Gly Ser Phe Gly Ser 
        835                 840                 845             


Ile Asp His Leu Gln Lys Leu Asp Glu Gln Lys Lys Trp Leu Asp Glu 
    850                 855                 860                 


Glu Val Glu Lys Val Leu Asn Gln Arg Gln Glu Leu Glu Glu Leu Glu 
865                 870                 875                 880 


Ala Asp Leu Lys Lys Arg Glu Ala Ile Val Ser Lys Lys Glu Ala Leu 
                885                 890                 895     


Leu Gln Glu Lys Ser His Leu Glu Asn Lys Lys Leu Arg Ser Ser Gln 
            900                 905                 910         


Ala Leu Asn Thr Asp Ser Leu Lys Ile Ser Thr Arg Leu Asn Leu Leu 
        915                 920                 925             


Glu Gln Glu Leu Ser Glu Lys Asn Val Gln Leu Gln Thr Ser Thr Ala 
    930                 935                 940                 


Glu Glu Lys Thr Lys Ile Ser Glu Gln Val Glu Val Leu Gln Lys Glu 
945                 950                 955                 960 


Lys Asp Gln Leu Gln Lys Arg Arg His Asn Val Asp Glu Lys Leu Lys 
                965                 970                 975     


Asn Gly Arg Val Leu Ser Pro Glu Glu Glu His Val Leu Phe Gln Leu 
            980                 985                 990         


Glu Glu Gly Ile Glu Ala Leu Glu  Ala Ala Ile Glu Tyr  Arg Asn Glu 
        995                 1000                 1005             


Ser Ile  Gln Asn Arg Gln Lys  Ser Leu Arg Ala Ser  Phe His Asn 
    1010                 1015                 1020             


Leu Ser  Arg Gly Glu Ala Asn  Val Leu Glu Lys Leu  Ala Cys Leu 
    1025                 1030                 1035             


Ser Pro  Val Glu Ile Arg Thr  Ile Leu Phe Arg Tyr  Phe Asn Lys 
    1040                 1045                 1050             


Val Val  Asn Leu Arg Glu Ala  Glu Arg Lys Gln Gln  Leu Tyr Asn 
    1055                 1060                 1065             


Glu Glu  Met Lys Met Lys Val  Leu Glu Arg Asp Asn  Met Val Arg 
    1070                 1075                 1080             


Glu Leu  Glu Ser Ala Leu Asp  His Leu Lys Leu Gln  Cys Asp Arg 
    1085                 1090                 1095             


Arg Leu  Thr Leu Gln Gln Lys  Glu His Glu Gln Lys  Met Gln Leu 
    1100                 1105                 1110             


Leu Leu  His His Phe Lys Glu  Gln Asp Gly Glu Gly  Ile Met Glu 
    1115                 1120                 1125             


Thr Phe  Lys Thr Tyr Glu Asp  Lys Ile Gln Gln Leu  Glu Lys Asp 
    1130                 1135                 1140             


Leu Tyr  Phe Tyr Lys Lys Thr  Ser Arg Asp His Lys  Lys Lys Leu 
    1145                 1150                 1155             


Lys Glu  Leu Val Gly Glu Ala  Ile Arg Arg Gln Leu  Ala Pro Ser 
    1160                 1165                 1170             


Glu Tyr  Gln Glu Ala Gly Asp  Gly Val Leu Lys Pro  Glu Gly Gly 
    1175                 1180                 1185             


Gly Met  Leu Ser Glu Glu Leu  Lys Trp Ala Ser Arg  Pro Glu Ser 
    1190                 1195                 1200             


Met Lys  Leu Ser Gly Arg Glu  Arg Glu Met Asp Ser  Ser Ala Ser 
    1205                 1210                 1215             


Ser Leu  Arg Thr Gln Pro Asn  Pro Gln Lys Leu Trp  Glu Asp Ile 
    1220                 1225                 1230             


Pro Glu  Leu Pro Pro Ile His  Ser Ser Leu Ala Pro  Pro Ser Gly 
    1235                 1240                 1245             


His Met  Leu Gly Asn Glu Asn  Lys Thr Glu Thr Asp  Asp Asn Gln 
    1250                 1255                 1260             


Phe Thr  Lys Ser His Ser Arg  Leu Ser Ser Gln Ile  Gln Val Val 
    1265                 1270                 1275             


Gly Asn  Val Gly Arg Leu His  Gly Val Thr Pro Val  Lys Leu Cys 
    1280                 1285                 1290             


Arg Lys  Glu Leu Arg Gln Ile  Ser Ala Leu Glu Leu  Ser Leu Arg 
    1295                 1300                 1305             


Arg Ser  Ser Leu Gly Val Gly  Ile Gly Ser Met Ala  Ala Asp Ser 
    1310                 1315                 1320             


Ile Glu  Val Ser Arg Lys Pro  Arg Asp Leu Lys Thr  
    1325                 1330                 1335 


<210> 7269
<211> 914
<212> PRT
<213> Homo sapiens

<400> 7269
Met Glu Glu Arg Ile Thr Thr Leu Glu Lys Arg Tyr Leu Ala Ala Gln 
1               5                   10                  15      


Arg Glu Ala Thr Ser Ile His Asp Leu Asn Asp Lys Leu Glu Asn Glu 
            20                  25                  30          


Leu Ala Asn Lys Glu Ser Leu His Arg Gln Cys Glu Glu Lys Ala Arg 
        35                  40                  45              


His Leu Gln Glu Leu Leu Glu Val Ala Glu Gln Lys Leu Gln Gln Thr 
    50                  55                  60                  


Met Arg Lys Ala Glu Thr Leu Pro Glu Val Glu Ala Glu Leu Ala Gln 
65                  70                  75                  80  


Arg Ile Ala Ala Leu Thr Lys Ala Glu Glu Arg His Gly Asn Ile Glu 
                85                  90                  95      


Glu His Leu Arg Gln Leu Glu Gly Gln Leu Glu Glu Lys Asn Gln Glu 
            100                 105                 110         


Leu Ala Arg Val Arg Gln Arg Glu Lys Met Asn Glu Asp His Asn Lys 
        115                 120                 125             


Arg Leu Ser Asp Thr Val Asp Arg Leu Leu Ser Glu Ser Asn Glu Arg 
    130                 135                 140                 


Leu Gln Leu His Leu Lys Glu Arg Met Ala Ala Leu Glu Glu Lys Asn 
145                 150                 155                 160 


Thr Leu Ile Gln Glu Leu Glu Ser Ser Gln Arg Gln Ile Glu Glu Gln 
                165                 170                 175     


His His His Lys Gly Arg Leu Ser Glu Glu Ile Glu Lys Leu Arg Gln 
            180                 185                 190         


Glu Val Asp Gln Leu Lys Gly Arg Gly Gly Pro Phe Val Asp Gly Val 
        195                 200                 205             


His Ser Arg Ser His Met Gly Ser Ala Ala Asp Val Arg Phe Ser Leu 
    210                 215                 220                 


Gly Thr Thr Thr His Ala Pro Pro Gly Val His Arg Arg Tyr Ser Ala 
225                 230                 235                 240 


Leu Arg Glu Glu Ser Ala Lys Asp Trp Glu Thr Ser Pro Leu Pro Gly 
                245                 250                 255     


Met Leu Ala Pro Ala Ala Gly Pro Ala Phe Asp Ser Asp Pro Glu Ile 
            260                 265                 270         


Ser Asp Val Asp Glu Asp Glu Pro Gly Gly Leu Val Gly Ser Ala Asp 
        275                 280                 285             


Val Val Ser Pro Ser Gly His Ser Asp Ala Gln Thr Leu Ala Met Met 
    290                 295                 300                 


Leu Gln Glu Gln Leu Asp Ala Ile Asn Glu Glu Ile Arg Met Ile Gln 
305                 310                 315                 320 


Glu Glu Lys Glu Ser Thr Glu Leu Arg Ala Glu Glu Ile Glu Thr Arg 
                325                 330                 335     


Val Thr Ser Gly Ser Met Glu Ala Leu Asn Leu Lys Gln Leu Arg Lys 
            340                 345                 350         


Arg Gly Ser Ile Pro Thr Ser Leu Thr Ala Leu Ser Leu Ala Ser Ala 
        355                 360                 365             


Ser Pro Pro Leu Ser Gly Arg Ser Thr Pro Lys Leu Thr Ser Arg Ser 
    370                 375                 380                 


Ala Ala Gln Asp Leu Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp 
385                 390                 395                 400 


Leu Arg Lys His Arg Arg Lys Leu Leu Ser Pro Val Ser Arg Glu Glu 
                405                 410                 415     


Asn Arg Glu Asp Lys Ala Thr Ile Lys Cys Glu Thr Ser Pro Pro Ser 
            420                 425                 430         


Ser Pro Arg Thr Leu Arg Leu Glu Lys Leu Gly His Pro Ala Leu Ser 
        435                 440                 445             


Gln Glu Glu Gly Lys Ser Ala Leu Glu Asp Gln Gly Ser Asn Pro Ser 
    450                 455                 460                 


Ser Ser Asn Ser Ser Gln Asp Ser Leu His Lys Gly Ala Lys Arg Lys 
465                 470                 475                 480 


Gly Ile Lys Ser Ser Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Gly 
                485                 490                 495     


Arg Leu Ile Gln Leu Ser Arg Asp Gly Ala Thr Gly His Val Leu Leu 
            500                 505                 510         


Thr Asp Ser Glu Phe Ser Met Gln Glu Pro Met Val Pro Ala Lys Leu 
        515                 520                 525             


Gly Thr Gln Ala Glu Lys Asp Arg Arg Leu Lys Lys Lys His Gln Leu 
    530                 535                 540                 


Leu Glu Asp Ala Arg Arg Lys Gly Met Pro Phe Ala Gln Trp Asp Gly 
545                 550                 555                 560 


Pro Thr Val Val Ser Trp Leu Glu Leu Trp Val Gly Met Pro Ala Trp 
                565                 570                 575     


Tyr Val Ala Ala Cys Arg Ala Asn Val Lys Ser Gly Ala Ile Met Ser 
            580                 585                 590         


Ala Leu Ser Asp Thr Glu Ile Gln Arg Glu Ile Gly Ile Ser Asn Ala 
        595                 600                 605             


Leu His Arg Leu Lys Leu Arg Leu Ala Ile Gln Glu Met Val Ser Leu 
    610                 615                 620                 


Thr Ser Pro Ser Ala Pro Pro Thr Ser Arg Thr Ser Ser Gly Asn Val 
625                 630                 635                 640 


Trp Val Thr His Glu Glu Met Glu Thr Leu Glu Thr Ser Thr Lys Thr 
                645                 650                 655     


Asp Ser Glu Glu Gly Ser Trp Ala Gln Thr Leu Ala Tyr Gly Asp Met 
            660                 665                 670         


Asn His Glu Trp Ile Gly Asn Glu Trp Leu Pro Ser Leu Gly Leu Pro 
        675                 680                 685             


Gln Tyr Arg Ser Tyr Phe Met Glu Cys Leu Val Asp Ala Arg Met Leu 
    690                 695                 700                 


Asp His Leu Thr Lys Lys Asp Leu Arg Val His Leu Lys Met Val Asp 
705                 710                 715                 720 


Ser Phe His Arg Thr Ser Leu Gln Tyr Gly Ile Met Cys Leu Lys Arg 
                725                 730                 735     


Leu Asn Tyr Asp Arg Lys Glu Leu Glu Lys Arg Arg Glu Glu Ser Gln 
            740                 745                 750         


His Glu Ile Lys Asp Val Leu Val Trp Thr Asn Asp Gln Val Val His 
        755                 760                 765             


Trp Val Gln Ser Ile Gly Leu Arg Asp Tyr Ala Gly Asn Leu His Glu 
    770                 775                 780                 


Ser Gly Val His Gly Ala Leu Leu Ala Leu Asp Glu Asn Phe Asp His 
785                 790                 795                 800 


Asn Thr Leu Ala Leu Ile Leu Gln Ile Pro Thr Gln Asn Thr Gln Ala 
                805                 810                 815     


Arg Gln Val Met Glu Arg Glu Phe Asn Asn Leu Leu Ala Leu Gly Thr 
            820                 825                 830         


Asp Arg Lys Leu Asp Asp Gly Asp Asp Lys Val Phe Arg Arg Ala Pro 
        835                 840                 845             


Ser Trp Arg Lys Arg Phe Arg Pro Arg Glu His His Gly Arg Gly Gly 
    850                 855                 860                 


Met Leu Ser Ala Ser Ala Glu Thr Leu Pro Ala Gly Phe Arg Val Ser 
865                 870                 875                 880 


Thr Leu Gly Thr Leu Gln Pro Pro Pro Ala Pro Pro Lys Lys Ile Met 
                885                 890                 895     


Pro Glu Ala His Ser His Tyr Leu Tyr Gly His Met Leu Ser Ala Phe 
            900                 905                 910         


Arg Asp 
        


<210> 7270
<211> 497
<212> PRT
<213> Homo sapiens

<400> 7270
Asp Val Gly Gly Asp Arg Pro Trp Asp Ser Gly Asn Thr Gln Leu Pro 
1               5                   10                  15      


Pro Arg Asn Pro Val Lys Ala Asn Ala Met Phe Gly Ala Gly Asp Glu 
            20                  25                  30          


Asp Asp Thr Asp Phe Leu Ser Pro Ser Gly Gly Ala Arg Leu Ala Ser 
        35                  40                  45              


Leu Phe Gly Leu Asp Gln Ala Ala Ala Gly His Gly Asn Glu Phe Phe 
    50                  55                  60                  


Gln Tyr Thr Ala Pro Lys Gln Pro Lys Lys Gly Gln Gly Thr Ala Ala 
65                  70                  75                  80  


Thr Gly Asn Gln Ala Thr Pro Lys Thr Ala Pro Ala Thr Met Ser Thr 
                85                  90                  95      


Pro Thr Ile Leu Val Ala Thr Ala Val His Ala Tyr Arg Tyr Thr Asn 
            100                 105                 110         


Gly Gln Tyr Val Lys Gln Gly Lys Phe Gly Ala Ala Val Leu Gly Asn 
        115                 120                 125             


His Thr Ala Arg Glu Tyr Arg Ile Leu Leu Tyr Ile Ser Gln Gln Gln 
    130                 135                 140                 


Pro Val Thr Val Ala Arg Ile His Val Asn Phe Glu Leu Met Val Arg 
145                 150                 155                 160 


Pro Asn Asn Tyr Ser Thr Phe Tyr Asp Asp Gln Arg Gln Asn Trp Ser 
                165                 170                 175     


Ile Met Phe Glu Ser Glu Lys Ala Ala Val Glu Phe Asn Lys Gln Val 
            180                 185                 190         


Cys Ile Ala Lys Cys Asn Ser Thr Ser Ser Leu Asp Ala Val Leu Ser 
        195                 200                 205             


Gln Asp Leu Ile Val Ala Asp Gly Pro Ala Val Glu Val Gly Asp Ser 
    210                 215                 220                 


Leu Glu Val Ala Tyr Thr Gly Trp Leu Phe Gln Asn His Val Leu Gly 
225                 230                 235                 240 


Gln Val Phe Asp Ser Thr Ala Asn Lys Asp Lys Leu Leu Arg Leu Lys 
                245                 250                 255     


Leu Gly Ser Gly Lys Val Ile Lys Gly Trp Glu Asp Gly Met Leu Gly 
            260                 265                 270         


Met Lys Lys Gly Gly Lys Arg Leu Leu Ile Val Pro Pro Ala Cys Ala 
        275                 280                 285             


Val Gly Ser Glu Gly Val Ile Gly Trp Thr Gln Ala Thr Asp Ser Ile 
    290                 295                 300                 


Leu Val Phe Glu Val Glu Val Arg Arg Val Lys Phe Ala Arg Asp Ser 
305                 310                 315                 320 


Gly Ser Asp Gly His Ser Val Ser Ser Arg Asp Ser Ala Ala Pro Ser 
                325                 330                 335     


Pro Ile Pro Gly Ala Asp Asn Leu Ser Ala Asp Pro Val Val Ser Pro 
            340                 345                 350         


Pro Thr Ser Ile Pro Phe Lys Ser Gly Glu Pro Ala Leu Arg Thr Lys 
        355                 360                 365             


Ser Asn Ser Leu Ser Glu Gln Leu Ala Ile Asn Thr Ser Pro Asp Ala 
    370                 375                 380                 


Val Lys Ala Lys Leu Ile Ser Arg Met Ala Lys Met Gly Gln Pro Met 
385                 390                 395                 400 


Leu Pro Ile Leu Pro Pro Gln Leu Asp Ser Asn Asp Ser Glu Ile Glu 
                405                 410                 415     


Asp Val Asn Thr Leu Gln Gly Gly Gly Gln Pro Val Val Thr Pro Ser 
            420                 425                 430         


Val Gln Pro Ser Leu His Pro Ala His Pro Ala Leu Pro Gln Met Thr 
        435                 440                 445             


Ser Gln Ala Pro Gln Pro Ser Val Thr Gly Leu Gln Ala Pro Ser Ala 
    450                 455                 460                 


Ala Leu Met Gln Val Ser Ser Leu Asp Ser His Ser Ala Val Ser Gly 
465                 470                 475                 480 


Asn Ala Gln Ser Phe Gln Val Thr Phe Tyr Asn Arg Ile Asn Tyr Ile 
                485                 490                 495     


Leu 
    


<210> 7271
<211> 153
<212> PRT
<213> Homo sapiens

<400> 7271
Met Asn Leu Ala Glu Ile Cys Asp Asn Ala Lys Lys Gly Arg Glu Tyr 
1               5                   10                  15      


Ala Leu Leu Gly Asn Tyr Asp Ser Ser Met Val Tyr Tyr Gln Gly Val 
            20                  25                  30          


Met Gln Gln Ile Gln Arg His Cys Gln Ser Val Arg Asp Pro Ala Ile 
        35                  40                  45              


Lys Gly Lys Trp Gln Gln Val Arg Gln Glu Leu Leu Glu Glu Tyr Glu 
    50                  55                  60                  


Gln Val Lys Ser Ile Val Ser Thr Leu Glu Ser Phe Lys Ile Asp Lys 
65                  70                  75                  80  


Pro Pro Asp Phe Pro Val Ser Cys Gln Asp Glu Pro Phe Arg Asp Pro 
                85                  90                  95      


Ala Val Trp Pro Pro Pro Val Pro Ala Glu His Arg Ala Pro Pro Gln 
            100                 105                 110         


Ile Arg Arg Pro Asn Arg Glu Val Arg Pro Leu Arg Lys Glu Met Ala 
        115                 120                 125             


Gly Val Gly Ala Arg Gly Pro Val Gly Arg Ala His Pro Ile Ser Lys 
    130                 135                 140                 


Ser Glu Lys Pro Ser Thr Ser Arg Asp 
145                 150             


<210> 7272
<211> 208
<212> PRT
<213> Homo sapiens

<400> 7272
Met Phe Gln Val Pro Asp Ser Glu Gly Gly Arg Ala Gly Ser Arg Ala 
1               5                   10                  15      


Met Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe Gly Ser Pro Glu 
            20                  25                  30          


Glu Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ala Ser Asn Ile Phe 
        35                  40                  45              


Gly Pro Thr Glu Glu Pro Gln Asn Ile Pro Lys Arg Thr Asn Pro Pro 
    50                  55                  60                  


Gly Gly Lys Gly Ser Gly Ile Phe Asp Glu Ser Thr Pro Val Gln Thr 
65                  70                  75                  80  


Arg Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser Asp Ile Phe Gly 
                85                  90                  95      


Ser Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro Asn Lys Pro Thr 
            100                 105                 110         


Arg Asn Ser Arg Asp Arg Val Ala Met Phe Ser Phe Pro Phe Ala Gln 
        115                 120                 125             


Met Ser Gly Val Gly Arg Gly Leu Val Leu Cys Glu Pro Gly Cys Ser 
    130                 135                 140                 


Ala Ser Pro Gly Arg His Asp Ser Cys Leu Glu Thr Arg Ala Phe Gln 
145                 150                 155                 160 


Met Ala Gly Arg Cys Leu Cys Gly Asp Glu Met Gly His Pro Trp Pro 
                165                 170                 175     


Ser Leu Met Cys Ser Pro Gly Leu Arg Gly Thr Gly Arg Gly Val Arg 
            180                 185                 190         


Val Gly Arg Trp Gly Arg Ala Trp Ser Leu Asp Gln Gln Pro Ala Ser 
        195                 200                 205             


<210> 7273
<211> 196
<212> PRT
<213> Homo sapiens

<400> 7273
Met Pro Phe Ser Lys Glu Lys Tyr Ile Leu Asp Ser Ser Pro Glu Lys 
1               5                   10                  15      


Leu His Lys Glu Leu Glu Glu Glu Leu Lys Leu Ser Ser Thr Asp Leu 
            20                  25                  30          


Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro Arg Glu Val Ser Glu 
        35                  40                  45              


Thr Leu Val Gln Arg Asn Gly Asp Phe Leu Ile Arg Asp Ser Leu Thr 
    50                  55                  60                  


Ser Leu Gly Asp Tyr Val Leu Thr Cys Arg Trp Arg Asn Gln Ala Leu 
65                  70                  75                  80  


His Phe Lys Ile Asn Lys Val Val Val Lys Ala Gly Glu Ser Tyr Thr 
                85                  90                  95      


His Ile Gln Tyr Leu Phe Glu Gln Glu Ser Phe Asp His Val Pro Ala 
            100                 105                 110         


Leu Val Arg Tyr His Val Gly Ser Arg Lys Ala Val Ser Glu Gln Ser 
        115                 120                 125             


Gly Ala Ile Ile Tyr Cys Pro Val Asn Arg Thr Phe Pro Leu Arg Tyr 
    130                 135                 140                 


Leu Glu Ala Ser Tyr Gly Leu Gly Gln Gly Ser Ser Lys Pro Ala Ser 
145                 150                 155                 160 


Pro Val Ser Pro Ser Gly Pro Lys Gly Ser His Met Lys Arg Arg Ser 
                165                 170                 175     


Val Thr Met Thr Asp Gly Leu Thr Ala Asp Lys Val Thr Arg Ser Asp 
            180                 185                 190         


Gly Cys Pro Thr 
        195     


<210> 7274
<211> 661
<212> PRT
<213> Homo sapiens

<400> 7274
Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Val Arg Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile 
        195                 200                 205             


Val Arg Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu 
    210                 215                 220                 


Glu Asp Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu 
225                 230                 235                 240 


Thr Pro Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr 
                245                 250                 255     


Leu Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu 
            260                 265                 270         


Gly Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr 
        275                 280                 285             


Tyr Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu 
    290                 295                 300                 


Leu Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn 
305                 310                 315                 320 


Thr Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His 
                325                 330                 335     


Val Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr 
            340                 345                 350         


Glu His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr 
        355                 360                 365             


Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val 
    370                 375                 380                 


Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His 
385                 390                 395                 400 


Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu 
                405                 410                 415     


Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val 
            420                 425                 430         


Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
        435                 440                 445             


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
    450                 455                 460                 


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
465                 470                 475                 480 


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
                485                 490                 495     


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
            500                 505                 510         


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
        515                 520                 525             


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
    530                 535                 540                 


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
545                 550                 555                 560 


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
                565                 570                 575     


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
            580                 585                 590         


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
        595                 600                 605             


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
    610                 615                 620                 


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
625                 630                 635                 640 


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
                645                 650                 655     


Ser Ser Met Asp Ser 
            660     


<210> 7275
<211> 370
<212> PRT
<213> Homo sapiens

<400> 7275
Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
1               5                   10                  15      


Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
            20                  25                  30          


Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
        35                  40                  45              


Asp Tyr Ala Gly Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser 
    50                  55                  60                  


Thr Gln Ala His Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn 
65                  70                  75                  80  


Gly Ser Leu Thr Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser 
                85                  90                  95      


Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg 
            100                 105                 110         


Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg 
        115                 120                 125             


Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile Phe 
    130                 135                 140                 


Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn Ser 
145                 150                 155                 160 


Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val Glu 
                165                 170                 175     


Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr Asn 
            180                 185                 190         


Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro Val 
        195                 200                 205             


Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe Gln 
    210                 215                 220                 


Ala Asp Val Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly Arg 
225                 230                 235                 240 


Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ser Leu Pro Leu Val Pro 
                245                 250                 255     


Gly Phe Pro Tyr Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly 
            260                 265                 270         


Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala 
        275                 280                 285             


Val Pro Pro Thr Ala Ile Pro Ala Tyr Pro Gly Val Asp Met Gln Pro 
    290                 295                 300                 


Thr Asp Met His Ser Leu Leu Leu Gln Pro Gln Pro Pro Leu Leu Gln 
305                 310                 315                 320 


Pro Leu Gln Pro Leu Thr Val Thr Val Met Ala Gly Cys Thr Gln Pro 
                325                 330                 335     


Thr Pro Thr Met Pro Leu Pro Leu Pro Leu Ala Met Glu Leu Ala Leu 
            340                 345                 350         


Trp Arg Val Tyr Thr Glu Val Ala Thr Ala Asp Leu Pro Pro Thr Glu 
        355                 360                 365             


Val Thr 
    370 


<210> 7276
<211> 115
<212> PRT
<213> Homo sapiens

<400> 7276
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro 
        115 


<210> 7277
<211> 1012
<212> PRT
<213> Homo sapiens

<400> 7277
Met Leu Leu Lys Ser Ile Phe Ile Val Tyr Ile Phe Phe Tyr Ser Ile 
1               5                   10                  15      


Ser Glu Leu Ser Leu Asp Ser Thr Leu His Ala Val Asn Leu His Cys 
            20                  25                  30          


Asn Asn Ile Ser Lys Ile Glu Ala Ile Asp His Ile Trp Asn Leu Gln 
        35                  40                  45              


His Leu Asp Leu Ser Ser Asn Gln Ile Ser Arg Ile Glu Gly Leu Asn 
    50                  55                  60                  


Thr Leu Thr Lys Leu Cys Thr Leu Asn Leu Ser Cys Asn Leu Ile Thr 
65                  70                  75                  80  


Lys Val Glu Gly Leu Glu Glu Leu Ile Asn Leu Thr Arg Leu Asn Val 
                85                  90                  95      


Ser Tyr Asn His Ile Asp Asp Leu Ser Gly Leu Ile Pro Leu His Gly 
            100                 105                 110         


Ile Lys His Lys Leu Arg Tyr Ile Asp Leu His Ser Asn Arg Ile Asp 
        115                 120                 125             


Ser Ile His His Leu Leu Gln Cys Met Val Gly Leu His Phe Leu Thr 
    130                 135                 140                 


Asn Leu Ile Leu Glu Lys Asp Gly Asp Asp Asn Pro Val Cys Arg Leu 
145                 150                 155                 160 


Pro Gly Tyr Arg Ala Val Ile Leu Gln Thr Leu Pro Gln Leu Arg Ile 
                165                 170                 175     


Leu Asp Cys Lys Asn Ile Phe Gly Glu Pro Val Asn Leu Thr Glu Ile 
            180                 185                 190         


Asn Ser Ser Gln Leu Gln Cys Leu Glu Gly Leu Leu Asp Asn Leu Val 
        195                 200                 205             


Ser Ser Asp Ser Pro Leu Asn Ile Ser Glu Asp Glu Ile Ile Asp Arg 
    210                 215                 220                 


Met Pro Val Ile Thr Ala Pro Ile Asp Glu Leu Val Pro Leu Glu Gln 
225                 230                 235                 240 


Phe Ala Ser Thr Pro Ser Asp Ala Val Leu Thr Ser Phe Met Ser Val 
                245                 250                 255     


Cys Gln Ser Ser Glu Pro Glu Lys Asn Asn His Glu Asn Asp Leu Gln 
            260                 265                 270         


Asn Glu Ile Lys Leu Gln Lys Leu Asp Asp Gln Ile Leu Gln Leu Leu 
        275                 280                 285             


Asn Glu Thr Ser Asn Ser Ile Asp Asn Val Leu Glu Lys Asp Pro Arg 
    290                 295                 300                 


Pro Lys Arg Asp Thr Asp Ile Thr Ser Glu Ser Asp Tyr Gly Asn Arg 
305                 310                 315                 320 


Lys Glu Cys Asn Arg Lys Val Pro Arg Arg Ser Lys Ile Pro Tyr Asp 
                325                 330                 335     


Ala Lys Thr Ile Gln Thr Ile Lys His His Asn Lys Asn Tyr Asn Ser 
            340                 345                 350         


Phe Val Ser Cys Asn Arg Lys Met Lys Pro Pro Tyr Leu Lys Glu Leu 
        355                 360                 365             


Tyr Val Ser Ser Ser Leu Ala Asn Cys Pro Met Leu Gln Glu Ser Glu 
    370                 375                 380                 


Lys Pro Lys Thr Glu Ile Ile Lys Val Asp Gln Ser His Ser Glu Asp 
385                 390                 395                 400 


Asn Thr Tyr Gln Ser Leu Val Glu Gln Leu Asp Gln Glu Arg Glu Lys 
                405                 410                 415     


Arg Trp Arg Ala Glu Gln Ala Glu Asn Lys Leu Met Asp Tyr Ile Asp 
            420                 425                 430         


Glu Leu His Lys His Ala Asn Glu Lys Glu Asp Ile His Ser Leu Ala 
        435                 440                 445             


Leu Leu Thr Thr Asp Arg Leu Lys Glu Ile Ile Phe Arg Glu Arg Asn 
    450                 455                 460                 


Ser Lys Gly Gln Leu Glu Val Met Val His Lys Leu Gln Asn Glu Ile 
465                 470                 475                 480 


Lys Lys Leu Thr Val Glu Leu Met Lys Ala Lys Asp Gln Gln Glu Asp 
                485                 490                 495     


His Leu Lys His Leu Arg Thr Leu Glu Lys Thr Leu Glu Lys Met Glu 
            500                 505                 510         


Arg Gln Lys Arg Gln Gln Gln Ala Ala Gln Ile Arg Leu Ile Gln Glu 
        515                 520                 525             


Val Glu Leu Lys Ala Ser Ala Ala Asp Arg Glu Ile Tyr Leu Leu Arg 
    530                 535                 540                 


Thr Ser Leu His Arg Glu Arg Glu Gln Ala Gln Gln Leu His Gln Leu 
545                 550                 555                 560 


Leu Ala Leu Lys Glu Gln Glu His Arg Lys Glu Leu Glu Thr Arg Glu 
                565                 570                 575     


Phe Phe Thr Asp Ala Asp Phe Gln Asp Ala Leu Ala Lys Glu Ile Ala 
            580                 585                 590         


Lys Glu Glu Lys Lys His Glu Gln Met Ile Lys Glu Tyr Gln Glu Lys 
        595                 600                 605             


Ile Asp Val Leu Ser Gln Gln Tyr Met Asp Leu Glu Asn Glu Phe Arg 
    610                 615                 620                 


Ile Ala Leu Thr Val Glu Ala Arg Arg Phe Gln Asp Val Lys Asp Gly 
625                 630                 635                 640 


Phe Glu Asn Val Ala Thr Glu Leu Ala Lys Ser Lys His Ala Leu Ile 
                645                 650                 655     


Trp Ala Gln Arg Lys Glu Asn Glu Ser Ser Ser Leu Ile Lys Asp Leu 
            660                 665                 670         


Thr Cys Met Val Lys Glu Gln Lys Thr Lys Leu Ala Glu Val Ser Lys 
        675                 680                 685             


Leu Lys Gln Glu Thr Ala Ala Asn Leu Gln Asn Gln Ile Asn Thr Leu 
    690                 695                 700                 


Glu Ile Leu Ile Glu Asp Asp Lys Gln Lys Ser Ile Gln Ile Glu Leu 
705                 710                 715                 720 


Leu Lys His Glu Lys Val Gln Leu Ile Ser Glu Leu Ala Ala Lys Glu 
                725                 730                 735     


Ser Leu Ile Phe Gly Leu Arg Thr Glu Arg Lys Val Trp Gly His Glu 
            740                 745                 750         


Leu Ala Gln Gln Gly Ser Ser Leu Ala Gln Asn Arg Gly Lys Leu Glu 
        755                 760                 765             


Ala Gln Ile Glu Ser Leu Ser Arg Glu Asn Glu Cys Leu Arg Lys Thr 
    770                 775                 780                 


Asn Glu Ser Asp Ser Asp Ala Leu Arg Ile Lys Cys Lys Ile Ile Asp 
785                 790                 795                 800 


Asp Gln Thr Glu Thr Ile Arg Lys Leu Lys Asp Cys Leu Gln Glu Lys 
                805                 810                 815     


Asp Glu His Ile Lys Arg Leu Gln Glu Lys Ile Thr Glu Ile Glu Lys 
            820                 825                 830         


Cys Thr Gln Glu Gln Leu Asp Glu Lys Ser Ser Gln Leu Asp Glu Val 
        835                 840                 845             


Leu Glu Lys Leu Glu Arg His Asn Glu Arg Lys Glu Lys Leu Lys Gln 
    850                 855                 860                 


Gln Leu Lys Gly Lys Glu Val Glu Leu Glu Glu Ile Arg Lys Ala Tyr 
865                 870                 875                 880 


Ser Thr Leu Asn Arg Lys Trp His Asp Lys Gly Glu Leu Leu Cys His 
                885                 890                 895     


Leu Glu Thr Gln Val Lys Glu Val Lys Glu Lys Phe Glu Asn Lys Glu 
            900                 905                 910         


Lys Lys Leu Lys Ala Glu Arg Asp Lys Ser Ile Glu Leu Gln Lys Asn 
        915                 920                 925             


Ala Met Glu Lys Leu His Ser Met Asp Asp Ala Phe Lys Arg Gln Val 
    930                 935                 940                 


Asp Ala Ile Val Glu Ala His Gln Ala Glu Ile Ala Gln Leu Ala Asn 
945                 950                 955                 960 


Glu Lys Gln Lys Cys Ile Asp Ser Ala Asn Leu Lys Val His Gln Ile 
                965                 970                 975     


Glu Lys Glu Met Arg Glu Leu Leu Glu Glu Thr Cys Lys Asn Lys Lys 
            980                 985                 990         


Thr Met Glu Ala Lys Ile Lys Gln  Leu Ala Phe Ala Leu  Asn Glu Ile 
        995                 1000                 1005             


Gln Gln  Asp Met 
    1010         


<210> 7278
<211> 1554
<212> PRT
<213> Homo sapiens

<400> 7278
Met Ser Ala Thr Ser Trp Phe Leu Val Ser Ser Ser Gly Ala Arg His 
1               5                   10                  15      


Arg Leu Pro Arg Glu Leu Ile Phe Val Gly Arg Glu Glu Cys Glu Leu 
            20                  25                  30          


Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr 
        35                  40                  45              


Asp Gln Asp Arg Asp Glu His Trp Val Lys Asp Leu Gly Ser Leu Asn 
    50                  55                  60                  


Gly Thr Phe Val Asn Asp Met Arg Ile Pro Asp Gln Lys Tyr Val Thr 
65                  70                  75                  80  


Leu Lys Leu Asn Asp Val Ile Arg Phe Gly Tyr Asp Ser Asn Met Tyr 
                85                  90                  95      


Val Leu Glu Arg Val Gln His Arg Val Pro Glu Glu Ala Leu Lys His 
            100                 105                 110         


Glu Lys Tyr Thr Ser Gln Leu Gln Val Ser Val Lys Gly Leu Ala Pro 
        115                 120                 125             


Lys Arg Ser Glu Ala Leu Pro Glu His Thr Pro Tyr Cys Glu Ala Ser 
    130                 135                 140                 


Asn Pro Arg Pro Glu Lys Gly Asp Arg Arg Pro Gly Thr Glu Ala Ala 
145                 150                 155                 160 


Ser Tyr Arg Thr Pro Leu Tyr Gly Gln Pro Ser Trp Trp Gly Glu Asp 
                165                 170                 175     


Asp Gly Ser Thr Leu Pro Asp Ala Gln Arg Gln Gly Glu Pro Tyr Pro 
            180                 185                 190         


Glu Arg Pro Lys Gly Pro Val Gln Gln Asp Gly Glu Leu His Gly Phe 
        195                 200                 205             


Arg Ala Pro Ala Glu Pro Gln Gly Cys Ser Phe Arg Arg Glu Pro Ser 
    210                 215                 220                 


Tyr Phe Glu Ile Pro Thr Lys Glu Thr Pro Gln Pro Ser Gln Pro Pro 
225                 230                 235                 240 


Glu Val Pro Ala His Glu Met Pro Thr Lys Asp Ala Glu Ala Gly Gly 
                245                 250                 255     


Gly Gly Ala Ala Pro Val Val Gln Ser His Ala Ser Phe Thr Ile Glu 
            260                 265                 270         


Phe Asp Asp Cys Ser Pro Gly Lys Met Lys Ile Lys Asp His Ile Thr 
        275                 280                 285             


Lys Phe Ser Leu Arg Gln Arg Arg Pro Pro Gly Lys Glu Ala Thr Pro 
    290                 295                 300                 


Gly Glu Met Val Ser Ala Glu Thr Lys Val Ala Asp Trp Leu Val Gln 
305                 310                 315                 320 


Asn Asp Pro Ser Leu Leu His Arg Val Gly Pro Gly Asp Asp Arg His 
                325                 330                 335     


Ser Thr Lys Ser Asp Leu Pro Val His Thr Arg Thr Leu Lys Gly His 
            340                 345                 350         


Lys His Glu Asp Gly Thr Gln Ser Asp Ser Glu Asp Pro Leu Ala Lys 
        355                 360                 365             


Ala Ala Ser Ala Ala Gly Val Pro Leu Glu Ala Ser Gly Glu Gln Val 
    370                 375                 380                 


Arg Leu Gln Arg Gln Ile Lys Arg Asp Pro Gln Glu Leu Leu His Asn 
385                 390                 395                 400 


Gln Gln Ala Phe Val Ile Glu Phe Phe Asp Glu Asp Thr Pro Arg Lys 
                405                 410                 415     


Lys Arg Ser Gln Ser Phe Thr His Ser Pro Ser Gly Asp Pro Lys Ala 
            420                 425                 430         


Asp Lys Arg Arg Gly Pro Thr Pro Ala Asp Arg Asp Arg Pro Ser Val 
        435                 440                 445             


Pro Ala Pro Val Gln Ala Gly Gly Arg Ser Ser Gly Pro Gln Arg Ala 
    450                 455                 460                 


Gly Ser Leu Lys Arg Glu Lys Thr Glu Glu Arg Leu Gly Ser Pro Ser 
465                 470                 475                 480 


Pro Ala Ser Arg Thr Pro Ala Arg Pro Phe Gly Ser Val Gly Arg Arg 
                485                 490                 495     


Ser Arg Leu Ala Gln Asp Phe Met Ala Gln Cys Leu Arg Glu Ser Ser 
            500                 505                 510         


Pro Ala Ala Arg Pro Ser Pro Glu Lys Val Pro Pro Val Leu Pro Ala 
        515                 520                 525             


Pro Leu Thr Pro His Gly Thr Ser Pro Val Gly Pro Pro Thr Pro Pro 
    530                 535                 540                 


Pro Ala Pro Thr Asp Pro Gln Leu Thr Lys Ala Arg Lys Gln Glu Glu 
545                 550                 555                 560 


Asp Asp Ser Leu Ser Asp Ala Gly Thr Tyr Thr Ile Glu Thr Glu Ala 
                565                 570                 575     


Gln Asp Thr Glu Val Glu Glu Ala Arg Lys Met Ile Asp Gln Val Phe 
            580                 585                 590         


Gly Val Leu Glu Ser Pro Glu Leu Ser Arg Ala Ser Ser Ala Thr Phe 
        595                 600                 605             


Arg Pro Val Ile Arg Gly Asp Arg Asp Glu Ser Asp Asp Gly Gly Val 
    610                 615                 620                 


Ala Gln Arg Met Ala Leu Leu Gln Glu Phe Ala Ser Arg Pro Leu Gly 
625                 630                 635                 640 


Ala Ala Pro Gln Ala Glu His Gln Gly Leu Pro Val Pro Gly Ser Pro 
                645                 650                 655     


Gly Gly Gln Lys Trp Val Ser Arg Trp Ala Ser Leu Ala Asp Ser Tyr 
            660                 665                 670         


Ser Asp Pro Gly Leu Thr Glu Asp Gly Leu Gly Arg Arg Gly Gly Glu 
        675                 680                 685             


Pro Glu Gly Ser Leu Pro Val Arg Met Arg Arg Arg Leu Pro Gln Leu 
    690                 695                 700                 


Pro Ser Glu Arg Ala Asp Ser Pro Ala Gly Pro Glu Ser Ser Arg Arg 
705                 710                 715                 720 


Ser Gly Pro Gly Pro Pro Glu Leu Asp Ser Glu Gln Pro Ser Arg Leu 
                725                 730                 735     


Phe Gly Gln Glu Glu Leu Asp Pro Asp Ser Leu Ser Asp Ala Ser Gly 
            740                 745                 750         


Ser Asp Gly Gly Arg Gly Pro Glu Pro Gly Val Glu Pro Gln Asp Ser 
        755                 760                 765             


Arg Arg Arg Ser Pro Gln Glu Gly Pro Thr Trp Ser Arg Gly Arg Arg 
    770                 775                 780                 


Ser Pro Arg Ala Pro Gly Glu Pro Thr Pro Ala Ser Phe Phe Ile Gly 
785                 790                 795                 800 


Asp Gln Asn Gly Asp Ala Val Leu Ser Arg Lys Pro Leu Ala Ala Pro 
                805                 810                 815     


Gly Asp Gly Glu Gly Leu Gly Gln Thr Ala Gln Pro Ser Pro Pro Ala 
            820                 825                 830         


Arg Asp Gly Val Tyr Val Ser Ala Asn Gly Arg Met Val Ile Gln Leu 
        835                 840                 845             


Arg Pro Gly Arg Ser Pro Glu Pro Asp Gly Pro Ala Pro Ala Phe Leu 
    850                 855                 860                 


Arg Gln Glu Ser Phe Thr Lys Glu Pro Ala Ser Gly Pro Pro Ala Pro 
865                 870                 875                 880 


Gly Lys Pro Pro His Ile Ser Ser His Pro Leu Leu Gln Asp Leu Ala 
                885                 890                 895     


Ala Thr Arg Ala Ala Arg Met Asp Phe His Ser Gln Asp Thr His Leu 
            900                 905                 910         


Ile Leu Lys Glu Thr Glu Thr Ala Leu Ala Ala Leu Glu Ala Arg Leu 
        915                 920                 925             


Leu Ser Asn Ser Val Asp Ala Glu Cys Glu Gly Gly Ser Thr Pro Arg 
    930                 935                 940                 


Pro Pro Glu Asp Ala Leu Ser Gly Asp Ser Asp Val Asp Thr Ala Ser 
945                 950                 955                 960 


Thr Val Ser Leu Arg Ser Gly Lys Ser Gly Pro Ser Pro Thr Thr Pro 
                965                 970                 975     


Gln Pro Leu Arg Ala Gln Lys Glu Met Ser Pro Ser Pro Pro Ala Ala 
            980                 985                 990         


Gln Asp Pro Gly Gly Thr Ala Leu  Val Ser Ala Arg Glu  Gln Ser Ser 
        995                 1000                 1005             


Glu Arg  Gln His His Pro Leu  Gly Pro Thr Asp Met  Gly Arg Gly 
    1010                 1015                 1020             


Glu Pro  Val Arg Arg Ser Ala  Ile Arg Arg Gly His  Arg Pro Arg 
    1025                 1030                 1035             


Gly Ser  Leu Asp Trp Pro Ser  Glu Glu Arg Gly Pro  Val Leu Ala 
    1040                 1045                 1050             


His Leu  Pro Ser Ser Asp Val  Met Ala Ser Asn His  Glu Thr Pro 
    1055                 1060                 1065             


Glu Ala  Thr Gly Ala Gly Arg  Leu Gly Ser Arg Arg  Lys Pro Ala 
    1070                 1075                 1080             


Ala Pro  Pro Pro Ser Pro Ala  Ala Arg Glu Glu Gln  Ser Arg Ser 
    1085                 1090                 1095             


Ser Ala  Ser Ser Gln Lys Gly  Pro Gln Ala Leu Thr  Arg Ser Asn 
    1100                 1105                 1110             


Ser Leu  Ser Thr Pro Arg Pro  Thr Arg Ala Ser Arg  Leu Arg Arg 
    1115                 1120                 1125             


Ala Arg  Leu Gly Asp Ala Ser  Asp Thr Glu Ala Ala  Asp Gly Glu 
    1130                 1135                 1140             


Arg Gly  Ser Leu Gly Asn Pro  Glu Pro Val Gly Arg  Pro Ala Ala 
    1145                 1150                 1155             


Glu Gln  Ala Lys Lys Leu Ser  Arg Leu Asp Ile Leu  Ala Met Pro 
    1160                 1165                 1170             


Arg Lys  Arg Ala Gly Ser Phe  Thr Gly Thr Ser Asp  Pro Glu Ala 
    1175                 1180                 1185             


Ala Pro  Ala Arg Thr Ser Phe  Ser Gly Arg Ser Val  Glu Leu Cys 
    1190                 1195                 1200             


Cys Ala  Ser Arg Lys Pro Thr  Met Ala Glu Ala Arg  Ala Val Ser 
    1205                 1210                 1215             


Arg Lys  Ala Ala Asn Thr Ala  Thr Thr Thr Gly Pro  Arg Gln Pro 
    1220                 1225                 1230             


Phe Ser  Arg Ala Arg Ser Gly  Ser Ala Arg Tyr Thr  Ser Thr Thr 
    1235                 1240                 1245             


Gln Thr  Pro Arg Ala Gly Ser  Ser Ser Arg Ala Arg  Ser Arg Ala 
    1250                 1255                 1260             


Pro Gly  Pro Arg Asp Thr Asp  Asp Asp Glu Glu Glu  Pro Asp Pro 
    1265                 1270                 1275             


Tyr Gly  Phe Ile Val Gln Thr  Ala Glu Ile Ala Glu  Ile Ala Arg 
    1280                 1285                 1290             


Leu Ser  Gln Thr Leu Val Lys  Asp Val Ala Ile Leu  Ala Gln Glu 
    1295                 1300                 1305             


Ile His  Asp Val Ala Gly Asp  Gly Asp Thr Leu Gly  Ser Ser Glu 
    1310                 1315                 1320             


Pro Ala  His Ser Ala Ser Leu  Ser Asn Met Pro Ser  Thr Pro Ala 
    1325                 1330                 1335             


Ser Thr  Ile Ser Ala Arg Glu  Glu Leu Val Gln Arg  Ile Pro Glu 
    1340                 1345                 1350             


Ala Ser  Leu Asn Phe Gln Lys  Val Pro Pro Gly Ser  Leu Asn Ser 
    1355                 1360                 1365             


Arg Asp  Phe Asp Gln Asn Met  Asn Asp Ser Cys Glu  Asp Ala Leu 
    1370                 1375                 1380             


Ala Asn  Lys Thr Arg Pro Arg  Asn Arg Glu Glu Val  Ile Phe Asp 
    1385                 1390                 1395             


Asn Leu  Met Leu Asn Pro Val  Ser Gln Leu Ser Gln  Ala Ile Arg 
    1400                 1405                 1410             


Glu Asn  Thr Glu His Leu Ala  Glu Lys Met Lys Ile  Leu Phe Gln 
    1415                 1420                 1425             


Asn Thr  Gly Arg Ala Trp Glu  Asp Leu Glu Ala Arg  Ile Asn Ala 
    1430                 1435                 1440             


Glu Asn  Glu Val Pro Ile Leu  Lys Thr Ser Asn Lys  Glu Ile Ser 
    1445                 1450                 1455             


Ser Ile  Leu Lys Glu Leu Arg  Arg Val Gln Lys Gln  Leu Glu Val 
    1460                 1465                 1470             


Ile Asn  Ala Ile Val Asp Pro  Ser Gly Ser Leu Asp  Leu Leu Thr 
    1475                 1480                 1485             


Gly Asn  Arg Ser Leu Ala Ser  Ser Ala Gln Pro Gly  Leu Gly Lys 
    1490                 1495                 1500             


Gly Arg  Val Ala Ala Gln Ser  Pro Pro Ser Pro Ala  Ser Ala Glu 
    1505                 1510                 1515             


Ala Leu  Leu Pro Ala Leu Pro  Leu Arg Asn Phe Pro  Gln Arg Ala 
    1520                 1525                 1530             


Ser Cys  Gly Pro Pro Ser Leu  Pro Asp Pro Thr Phe  Leu Pro Asp 
    1535                 1540                 1545             


Ala Glu  Arg Phe Leu Ile 
    1550                 


<210> 7279
<211> 231
<212> PRT
<213> Homo sapiens

<400> 7279
Ile Ile Leu Leu Leu Val Pro Ser Glu Glu Thr Asp Glu Asn Asp Leu 
1               5                   10                  15      


Ile Leu Glu Val Thr Ala Gly Val Gly Gly Gly Leu Arg His Ala Ser 
            20                  25                  30          


Ala Ser Ile Gly Gly Ser Glu Ala Tyr Arg His Met Lys Phe Glu Gly 
        35                  40                  45              


Gly Val His Arg Val Gln Arg Val Pro Lys Thr Glu Lys Gln Gly Arg 
    50                  55                  60                  


Val His Thr Ser Thr Met Thr Val Ala Ile Leu Pro Gln Pro Thr Glu 
65                  70                  75                  80  


Ile Asn Leu Val Ile Asn Pro Lys Asp Leu Arg Ile Asp Thr Lys Arg 
                85                  90                  95      


Ala Ser Gly Ala Gly Gly Gln His Val Asn Thr Thr Asp Ser Ala Val 
            100                 105                 110         


Arg Ile Val His Leu Pro Thr Gly Val Val Ser Glu Cys Gln Gln Glu 
        115                 120                 125             


Arg Ser Gln Leu Lys Asn Lys Glu Leu Ala Met Thr Lys Leu Arg Ala 
    130                 135                 140                 


Lys Leu Tyr Ser Met His Leu Glu Glu Glu Ile Asn Lys Arg Gln Asn 
145                 150                 155                 160 


Ala Arg Lys Ile Gln Ile Gly Ser Lys Gly Arg Ser Glu Lys Ile Arg 
                165                 170                 175     


Thr Tyr Asn Phe Pro Gln Asn Arg Val Thr Asp His Arg Ile Asn Lys 
            180                 185                 190         


Thr Leu His Asp Leu Glu Thr Phe Met Gln Gly Asp Tyr Leu Leu Asp 
        195                 200                 205             


Glu Leu Val Gln Ser Leu Lys Glu Tyr Ala Asp Tyr Glu Ser Leu Val 
    210                 215                 220                 


Glu Ile Ile Ser Gln Lys Val 
225                 230     


<210> 7280
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7280
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7281
<211> 140
<212> PRT
<213> Homo sapiens

<400> 7281
Met Gln Phe Gly Glu Leu Leu Ala Ala Val Arg Lys Ala Gln Ala Asn 
1               5                   10                  15      


Val Met Leu Phe Leu Glu Glu Lys Glu Gln Ala Ala Leu Ser Gln Ala 
            20                  25                  30          


Asn Gly Ile Lys Ala His Leu Glu Tyr Arg Ser Ala Glu Met Glu Lys 
        35                  40                  45              


Ser Lys Gln Glu Leu Glu Thr Met Ala Ala Ile Ser Asn Thr Val Gln 
    50                  55                  60                  


Phe Leu Glu Met Cys Met Thr Ser Arg Ser Thr Arg Thr Gln His Thr 
65                  70                  75                  80  


Ser Ile Ser Gly Cys Arg Arg Arg Thr Ala Arg Ser Pro Thr Pro Arg 
                85                  90                  95      


Pro Gly Ser Ile Pro Thr Arg Thr Ser Pro Ala Gly Ser Cys Thr Gly 
            100                 105                 110         


Gly Arg Cys Cys Pro Ser Arg Val Cys Thr Cys Thr Gly Thr Ile Leu 
        115                 120                 125             


Arg Trp Arg Ser Ser Gly Gln Ala Pro Met Leu Ala 
    130                 135                 140 


<210> 7282
<211> 272
<212> PRT
<213> Homo sapiens

<400> 7282
Met Ala Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr 
1               5                   10                  15      


Ser Ile Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu 
            20                  25                  30          


Gly Asp Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr 
        35                  40                  45              


Lys Ala Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg 
    50                  55                  60                  


Lys Phe Pro Lys Leu Thr Ile Ile Gly Glu Glu Leu Val Val Trp Val 
65                  70                  75                  80  


Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly Leu Leu Asp Asn 
                85                  90                  95      


Val Thr Val Leu Ile Gly Ile Ala Tyr Glu Gly Lys Ala Ile Ala Gly 
            100                 105                 110         


Val Ile Asn Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly Pro Asp Ala Val 
        115                 120                 125             


Leu Gly Arg Thr Ile Trp Gly Val Leu Gly Leu Gly Ala Phe Gly Phe 
    130                 135                 140                 


Gln Leu Lys Glu Val Pro Ala Gly Lys His Ile Ile Thr Thr Thr Arg 
145                 150                 155                 160 


Ser His Ser Asn Lys Leu Val Thr Asp Cys Val Ala Ala Met Asn Pro 
                165                 170                 175     


Asp Ala Val Leu Arg Val Gly Gly Ala Gly Asn Lys Ile Ile Gln Leu 
            180                 185                 190         


Ile Glu Gly Lys Ala Ser Ala Tyr Val Phe Ala Ser Pro Gly Cys Lys 
        195                 200                 205             


Lys Trp Asp Thr Cys Ala Pro Glu Val Ile Leu His Ala Val Gly Gly 
    210                 215                 220                 


Lys Leu Thr Asp Ile His Gly Asn Val Leu Gln Tyr His Lys Asp Val 
225                 230                 235                 240 


Lys His Met Asn Ser Ala Gly Val Leu Ala Thr Leu Arg Asn Tyr Asp 
                245                 250                 255     


Tyr Tyr Ala Ser Arg Val Pro Glu Ser Ile Lys Asn Ala Leu Val Pro 
            260                 265                 270         


<210> 7283
<211> 201
<212> PRT
<213> Homo sapiens

<400> 7283
Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys 
1               5                   10                  15      


Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val 
            20                  25                  30          


Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp 
        35                  40                  45              


Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro 
    50                  55                  60                  


Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly 
65                  70                  75                  80  


Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg 
                85                  90                  95      


Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala 
            100                 105                 110         


Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly 
        115                 120                 125             


Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro 
    130                 135                 140                 


Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr 
145                 150                 155                 160 


Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr 
                165                 170                 175     


Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Arg Arg Lys Leu Leu Pro 
        195                 200     


<210> 7284
<211> 634
<212> PRT
<213> Homo sapiens

<400> 7284
Met Ala Leu Ser Lys Arg Glu Leu Asp Glu Leu Lys Pro Trp Ile Glu 
1               5                   10                  15      


Lys Thr Val Lys Arg Val Leu Gly Phe Ser Glu Pro Thr Val Val Thr 
            20                  25                  30          


Ala Ala Leu Asn Cys Val Gly Lys Gly Met Asp Lys Lys Lys Ala Ala 
        35                  40                  45              


Asp His Leu Lys Pro Phe Leu Asp Asp Ser Thr Leu Arg Phe Val Asp 
    50                  55                  60                  


Lys Leu Phe Glu Ala Val Glu Glu Gly Arg Ser Ser Arg His Ser Lys 
65                  70                  75                  80  


Ser Ser Ser Asp Arg Ser Arg Lys Arg Glu Leu Lys Ile Lys Gln Met 
                85                  90                  95      


Met Glu Ala Ala Thr Arg Gln Ile Glu Glu Arg Lys Lys Gln Leu Ser 
            100                 105                 110         


Phe Ile Ser Pro Pro Thr Pro Gln Pro Lys Thr Pro Ser Ser Ser Gln 
        115                 120                 125             


Pro Glu Arg Leu Pro Ile Gly Asn Thr Ile Gln Pro Ser Gln Ala Ala 
    130                 135                 140                 


Thr Phe Met Asn Asp Ala Ile Glu Lys Ala Arg Lys Ala Ala Glu Leu 
145                 150                 155                 160 


Gln Ala Arg Ile Gln Ala Gln Leu Ala Leu Lys Pro Gly Leu Ile Gly 
                165                 170                 175     


Asn Ala Asn Met Val Gly Leu Ala Asn Leu His Ala Met Gly Ile Ala 
            180                 185                 190         


Pro Pro Lys Val Glu Leu Lys Asp Gln Thr Lys Pro Thr Pro Leu Ile 
        195                 200                 205             


Leu Asp Glu Gln Gly Arg Thr Val Asp Ala Thr Gly Lys Glu Ile Glu 
    210                 215                 220                 


Leu Thr His Arg Met Pro Thr Leu Lys Ala Asn Ile Arg Ala Val Lys 
225                 230                 235                 240 


Arg Glu Gln Phe Lys Gln Gln Leu Lys Glu Lys Pro Ser Glu Asp Met 
                245                 250                 255     


Glu Ser Asn Thr Phe Phe Asp Pro Arg Val Ser Ile Ala Pro Ser Gln 
            260                 265                 270         


Arg Gln Arg Arg Thr Phe Lys Phe His Asp Lys Gly Lys Phe Glu Lys 
        275                 280                 285             


Ile Ala Gln Arg Leu Arg Thr Lys Ala Gln Leu Glu Lys Leu Gln Ala 
    290                 295                 300                 


Glu Ile Ser Gln Ala Ala Arg Lys Thr Gly Ile His Thr Ser Thr Arg 
305                 310                 315                 320 


Leu Ala Leu Ile Ala Pro Lys Lys Glu Leu Lys Glu Gly Asp Ile Pro 
                325                 330                 335     


Glu Ile Glu Trp Trp Asp Ser Tyr Ile Ile Pro Asn Gly Phe Asp Leu 
            340                 345                 350         


Thr Glu Glu Asn Pro Lys Arg Glu Asp Tyr Phe Gly Ile Thr Asn Leu 
        355                 360                 365             


Val Glu His Pro Ala Gln Leu Asn Pro Pro Val Asp Asn Asp Thr Pro 
    370                 375                 380                 


Val Thr Leu Gly Val Tyr Leu Thr Lys Lys Glu Gln Lys Lys Leu Arg 
385                 390                 395                 400 


Arg Gln Thr Arg Arg Glu Ala Gln Lys Glu Leu Gln Glu Lys Val Arg 
                405                 410                 415     


Leu Gly Leu Met Pro Pro Pro Glu Pro Lys Val Arg Ile Ser Asn Leu 
            420                 425                 430         


Met Arg Val Leu Gly Thr Glu Ala Val Gln Asp Pro Thr Lys Val Glu 
        435                 440                 445             


Ala His Val Arg Ala Gln Met Ala Lys Arg Gln Lys Ala His Glu Glu 
    450                 455                 460                 


Ala Asn Ala Ala Arg Lys Leu Thr Ala Glu Gln Arg Lys Val Lys Lys 
465                 470                 475                 480 


Ile Lys Lys Leu Lys Glu Asp Ile Ser Gln Gly Val His Ile Ser Val 
                485                 490                 495     


Tyr Arg Val Arg Asn Leu Ser Asn Pro Ala Lys Lys Phe Lys Ile Glu 
            500                 505                 510         


Ala Asn Ala Gly Gln Leu Tyr Leu Thr Gly Val Val Val Leu His Lys 
        515                 520                 525             


Asp Val Asn Val Val Val Val Glu Gly Gly Pro Lys Ala Gln Lys Lys 
    530                 535                 540                 


Phe Lys Arg Leu Met Leu His Arg Ile Lys Trp Asp Glu Gln Thr Ser 
545                 550                 555                 560 


Asn Thr Lys Gly Asp Asp Asp Glu Glu Ser Asp Glu Glu Ala Val Lys 
                565                 570                 575     


Lys Thr Asn Lys Cys Val Leu Val Trp Glu Gly Thr Ala Lys Asp Arg 
            580                 585                 590         


Ser Phe Gly Glu Met Lys Phe Lys Gln Cys Pro Thr Glu Asn Met Ala 
        595                 600                 605             


Arg Glu His Phe Lys Lys His Gly Ala Glu His Tyr Trp Asp Leu Ala 
    610                 615                 620                 


Leu Ser Glu Ser Val Leu Glu Ser Thr Asp 
625                 630                 


<210> 7285
<211> 1063
<212> PRT
<213> Homo sapiens

<400> 7285
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 
                245                 250                 255     


Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 
            260                 265                 270         


Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 
        275                 280                 285             


Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 
    290                 295                 300                 


Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 
305                 310                 315                 320 


Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr 
                325                 330                 335     


Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro 
            340                 345                 350         


Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro 
        355                 360                 365             


Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro 
    370                 375                 380                 


His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala 
385                 390                 395                 400 


Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile 
                405                 410                 415     


Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly 
            420                 425                 430         


Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu 
        435                 440                 445             


Trp Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile 
    450                 455                 460                 


Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp 
465                 470                 475                 480 


Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu 
                485                 490                 495     


Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln 
            500                 505                 510         


His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp 
        515                 520                 525             


Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln 
    530                 535                 540                 


Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg 
545                 550                 555                 560 


Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu 
                565                 570                 575     


Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe 
            580                 585                 590         


Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg 
        595                 600                 605             


Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe 
    610                 615                 620                 


Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu 
625                 630                 635                 640 


Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly 
                645                 650                 655     


Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile 
            660                 665                 670         


Ile Ser Gly Val Glu Met Gln Val Leu Gln Glu Lys Leu Arg Ser Gly 
        675                 680                 685             


Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys 
    690                 695                 700                 


Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe 
705                 710                 715                 720 


Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val 
                725                 730                 735     


Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala 
            740                 745                 750         


Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro 
        755                 760                 765             


Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser 
    770                 775                 780                 


Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg 
785                 790                 795                 800 


Glu Leu Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn 
                805                 810                 815     


Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser 
            820                 825                 830         


Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu 
        835                 840                 845             


Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu 
    850                 855                 860                 


Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile 
865                 870                 875                 880 


Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln 
                885                 890                 895     


Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val 
            900                 905                 910         


Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg 
        915                 920                 925             


Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala 
    930                 935                 940                 


Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu 
945                 950                 955                 960 


Leu Pro Pro Gly Ala Ala Ala Pro Ser Gly Trp Ala Gln Ala Pro Leu 
                965                 970                 975     


Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly Leu Val Asp Pro 
            980                 985                 990         


Gln Ile Gln Leu Pro Leu Leu Ala  Ala Arg Arg Tyr Lys  Leu Gln Lys 
        995                 1000                 1005             


Gln Leu  Asp Ser Leu Thr Ala  Arg Thr Pro Ser Glu  Gly Glu Ala 
    1010                 1015                 1020             


Gly Thr  Gln Arg Gln Gln Lys  Leu Ser Ser Leu Gln  Leu Glu Leu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Lys Ala Ala  Ser His Leu Arg Gln  Leu Met Asp 
    1040                 1045                 1050             


Glu Pro  Pro Ala Pro Gly Ser  Pro Glu Leu 
    1055                 1060             


<210> 7286
<211> 705
<212> PRT
<213> Homo sapiens

<400> 7286
Met Ile Asp Ser Val Lys Leu Arg Arg Asp Ser Ala Ala Asp Phe Phe 
1               5                   10                  15      


Ser His Tyr Glu Tyr Leu Cys Ala Leu Gln Asn Ser Val Pro Leu Pro 
            20                  25                  30          


Ala Val Arg Ala Cys Leu Arg Glu Gly Val Leu Asp Phe Asn Ala Asp 
        35                  40                  45              


Arg Leu Arg Gly Val Asp Trp Ala Pro Leu Leu Ser Thr Leu Lys Ile 
    50                  55                  60                  


Asn Lys Asp Leu Pro Leu Val Ser Ile Lys Ser Phe Phe Gln Pro Trp 
65                  70                  75                  80  


Leu Gly Asp Thr Gly Ser Asp Met Asn Lys Phe Cys Arg Ser Arg Val 
                85                  90                  95      


Pro Ala Ile Arg Tyr Lys Asp Val Thr Phe Gln Leu Cys Lys Ala Leu 
            100                 105                 110         


Lys Gly Cys Leu Ser Ile Ser Ser Val Leu Lys Asn Leu Glu Leu Asn 
        115                 120                 125             


Gly Leu Ile Leu Arg Glu Arg Asp Leu Thr Ile Leu Ala Lys Gly Leu 
    130                 135                 140                 


Asn Lys Ser Ala Ser Leu Val His Leu Ser Leu Ala Asn Cys Pro Ile 
145                 150                 155                 160 


Gly Asp Gly Gly Leu Glu Ile Ile Cys Gln Gly Ile Lys Ser Ser Ile 
                165                 170                 175     


Thr Leu Lys Thr Val Asn Phe Thr Gly Cys Asn Leu Thr Trp Gln Gly 
            180                 185                 190         


Ala Asp His Met Ala Lys Ile Leu Lys Tyr Gln Thr Met Arg Arg His 
        195                 200                 205             


Glu Glu Thr Trp Ala Glu Ser Leu Arg Tyr Arg Arg Pro Asp Leu Asp 
    210                 215                 220                 


Cys Met Ala Gly Leu Arg Arg Ile Thr Leu Asn Cys Asn Thr Leu Ile 
225                 230                 235                 240 


Gly Asp Leu Gly Ala Cys Ala Phe Ala Asp Ser Leu Ser Glu Asp Leu 
                245                 250                 255     


Trp Leu Arg Ala Leu Asp Leu Gln Gln Cys Gly Leu Thr Asn Glu Gly 
            260                 265                 270         


Ala Lys Ala Leu Leu Glu Ala Leu Glu Thr Asn Thr Thr Leu Val Val 
        275                 280                 285             


Leu Asp Ile Arg Lys Asn Pro Leu Ile Asp His Ser Met Met Lys Ala 
    290                 295                 300                 


Val Ile Lys Lys Val Leu Gln Asn Gly Arg Ser Ala Lys Ser Glu Tyr 
305                 310                 315                 320 


Gln Trp Ile Thr Ser Pro Ser Val Lys Glu Pro Ser Lys Thr Ala Lys 
                325                 330                 335     


Gln Lys Arg Arg Thr Ile Ile Leu Gly Ser Gly His Lys Gly Lys Ala 
            340                 345                 350         


Thr Ile Arg Ile Gly Leu Ala Thr Lys Lys Pro Val Ser Ser Gly Arg 
        355                 360                 365             


Lys His Ser Leu Gly Lys Glu Tyr Tyr Ala Pro Ala Pro Leu Pro Pro 
    370                 375                 380                 


Gly Val Ser Gly Phe Leu Pro Trp Arg Thr Ala Glu Arg Ala Lys Arg 
385                 390                 395                 400 


His Arg Gly Phe Pro Leu Ile Lys Thr Arg Asp Ile Cys Asn Gln Leu 
                405                 410                 415     


Gln Gln Pro Gly Phe Pro Val Thr Val Thr Val Glu Ser Pro Ser Ser 
            420                 425                 430         


Ser Glu Val Glu Glu Val Asp Asp Ser Ser Glu Ser Val His Glu Val 
        435                 440                 445             


Pro Glu Lys Thr Ser Ile Glu Gln Glu Ala Leu Gln Glu Lys Leu Glu 
    450                 455                 460                 


Glu Cys Leu Lys Gln Leu Lys Glu Glu Arg Val Ile Arg Leu Lys Val 
465                 470                 475                 480 


Asp Lys Arg Val Ser Glu Leu Glu His Glu Asn Ala Gln Leu Arg Asn 
                485                 490                 495     


Ile Asn Phe Ser Leu Ser Glu Ala Leu His Ala Gln Ser Leu Thr Asn 
            500                 505                 510         


Met Ile Leu Asp Asp Glu Gly Val Leu Gly Ser Ile Glu Asn Ser Phe 
        515                 520                 525             


Gln Lys Phe His Ala Phe Leu Asp Leu Leu Lys Asp Ala Gly Leu Gly 
    530                 535                 540                 


Gln Leu Ala Thr Met Ala Gly Ile Asp Gln Ser Asp Phe Gln Leu Leu 
545                 550                 555                 560 


Gly His Pro Gln Met Thr Ser Thr Val Ser Asn Pro Pro Lys Glu Glu 
                565                 570                 575     


Lys Lys Ala Leu Glu Asp Glu Lys Pro Glu Pro Lys Gln Asn Ala Leu 
            580                 585                 590         


Gly Gln Met Gln Asn Ile Gln Val Ser Ile Cys Met Gln Ser Ala Tyr 
        595                 600                 605             


Asn Glu Gly Thr Leu Met Lys Phe Gln Lys Ile Thr Gly Asp Ala Arg 
    610                 615                 620                 


Ile Pro Leu Pro Leu Asp Ser Phe Pro Val Pro Val Ser Thr Pro Glu 
625                 630                 635                 640 


Gly Leu Gly Thr Ser Ser Asn Asn Leu Gly Val Pro Ala Thr Glu Gln 
                645                 650                 655     


Arg Gln Glu Ser Phe Glu Gly Phe Ile Ala Arg Met Cys Ser Pro Ser 
            660                 665                 670         


Pro Asp Ala Thr Ser Gly Thr Gly Ser Gln Arg Lys Glu Glu Glu Leu 
        675                 680                 685             


Ser Arg Asn Ser Arg Ser Ser Ser Glu Lys Lys Thr Lys Thr Gly Ser 
    690                 695                 700                 


His 
705 


<210> 7287
<211> 428
<212> PRT
<213> Homo sapiens

<400> 7287
Met Ala Trp Gln Ser Arg Lys Gly Gly His Phe Arg Glu Val Ala Met 
1               5                   10                  15      


Gln Trp Lys Val Thr Leu Thr Ser Arg Trp Gly Leu Leu Arg His Cys 
            20                  25                  30          


Gln Val Leu Ala Gly Leu Leu His Leu Gly Asn Ile Gln Phe Ala Ala 
        35                  40                  45              


Ser Glu Asp Glu Ala Gln Pro Cys Gln Pro Met Asp Asp Ala Lys Tyr 
    50                  55                  60                  


Ser Val Arg Thr Ala Ala Ser Leu Leu Gly Leu Pro Glu Asp Val Leu 
65                  70                  75                  80  


Leu Glu Met Val Gln Ile Arg Thr Ile Arg Ala Gly Arg Gln Gln Gln 
                85                  90                  95      


Val Phe Arg Lys Pro Cys Ala Arg Ala Glu Cys Asp Thr Arg Arg Asp 
            100                 105                 110         


Cys Leu Ala Lys Leu Ile Tyr Ala Arg Leu Phe Asp Trp Leu Val Ser 
        115                 120                 125             


Val Ile Asn Ser Ser Ile Cys Ala Asp Thr Asp Ser Trp Thr Thr Phe 
    130                 135                 140                 


Ile Gly Leu Leu Asp Val Tyr Gly Phe Glu Ser Phe Pro Asp Asn Ser 
145                 150                 155                 160 


Leu Glu Gln Leu Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln His 
                165                 170                 175     


Phe Val Ala His Tyr Leu Arg Ala Gln Gln Glu Glu Tyr Ala Val Glu 
            180                 185                 190         


Gly Leu Glu Trp Ser Phe Ile Asn Tyr Gln Asp Asn Gln Pro Cys Leu 
        195                 200                 205             


Asp Leu Ile Glu Gly Ser Pro Ile Ser Ile Cys Ser Leu Ile Asn Glu 
    210                 215                 220                 


Glu Cys Arg Leu Asn Arg Pro Ser Ser Ala Ala Gln Leu Gln Thr Arg 
225                 230                 235                 240 


Ile Glu Thr Ala Leu Ala Gly Ser Pro Cys Leu Gly His Asn Lys Leu 
                245                 250                 255     


Ser Arg Glu Pro Ser Phe Ile Val Val His Tyr Ala Gly Pro Val Arg 
            260                 265                 270         


Tyr His Thr Ala Gly Leu Val Glu Lys Asn Lys Asp Pro Ile Pro Pro 
        275                 280                 285             


Glu Leu Asp Gly Val Glu Glu Lys His Phe Ser Gln Ala Pro Cys Ser 
    290                 295                 300                 


Leu Ser Thr Ser Pro Leu Gln Thr Arg Leu Leu Glu Ala Ile Ile Arg 
305                 310                 315                 320 


Leu Trp Pro Leu Gly Leu Val Leu Ala Asn Thr Ala Met Gly Val Gly 
                325                 330                 335     


Ser Phe Gln Arg Lys Leu Val Val Trp Ala Cys Leu Gln Leu Pro Arg 
            340                 345                 350         


Gly Ser Pro Ser Ser Tyr Thr Val Gln Thr Ala Gln Asp Gln Ala Gly 
        355                 360                 365             


Val Thr Ser Ile Arg Ala Leu Pro Gln Gly Ser Ile Lys Phe His Cys 
    370                 375                 380                 


Arg Lys Ser Pro Leu Arg Tyr Ala Asp Ile Cys Pro Glu Pro Ser Pro 
385                 390                 395                 400 


Tyr Ser Ile Thr Gly Phe Asn Gln Ile Leu Leu Glu Arg His Arg Leu 
                405                 410                 415     


Ile His Val Thr Ser Ser Ala Phe Thr Gly Leu Gly 
            420                 425             


<210> 7288
<211> 308
<212> PRT
<213> Homo sapiens

<400> 7288
Met Asn Pro Ile Val Val Val His Gly Gly Gly Ala Gly Pro Ile Ser 
1               5                   10                  15      


Lys Asp Arg Lys Glu Arg Val His Gln Gly Met Val Arg Ala Ala Thr 
            20                  25                  30          


Val Gly Tyr Gly Ile Leu Arg Glu Gly Gly Ser Ala Val Asp Ala Val 
        35                  40                  45              


Glu Gly Ala Val Val Ala Leu Glu Asp Asp Pro Glu Phe Asn Ala Gly 
    50                  55                  60                  


Cys Gly Ser Val Leu Asn Thr Asn Gly Glu Val Glu Met Asp Ala Ser 
65                  70                  75                  80  


Ile Met Asp Gly Lys Asp Leu Ser Ala Gly Ala Val Ser Ala Val Gln 
                85                  90                  95      


Cys Ile Ala Asn Pro Ile Lys Leu Ala Arg Leu Val Met Glu Lys Thr 
            100                 105                 110         


Pro His Cys Phe Leu Thr Asp Gln Gly Ala Ala Gln Phe Ala Ala Ala 
        115                 120                 125             


Met Gly Val Pro Glu Ile Pro Gly Glu Lys Leu Val Thr Glu Arg Asn 
    130                 135                 140                 


Lys Lys Arg Leu Glu Lys Glu Lys His Glu Lys Gly Ala Gln Lys Thr 
145                 150                 155                 160 


Asp Cys Gln Lys Asn Leu Gly Thr Val Gly Ala Val Ala Leu Asp Cys 
                165                 170                 175     


Lys Gly Asn Val Ala Tyr Ala Thr Ser Thr Gly Gly Ile Val Asn Lys 
            180                 185                 190         


Met Val Gly Arg Val Gly Asp Ser Pro Cys Leu Gly Ala Gly Gly Tyr 
        195                 200                 205             


Ala Asp Asn Asp Ile Gly Ala Val Ser Thr Thr Gly His Gly Glu Ser 
    210                 215                 220                 


Ile Leu Lys Val Asn Leu Ala Arg Leu Thr Leu Phe His Ile Glu Gln 
225                 230                 235                 240 


Gly Lys Thr Val Glu Glu Ala Ala Asp Leu Ser Leu Gly Tyr Met Lys 
                245                 250                 255     


Ser Arg Val Lys Gly Leu Gly Gly Leu Ile Val Val Ser Lys Thr Gly 
            260                 265                 270         


Asp Trp Val Ala Lys Trp Thr Ser Thr Ser Met Pro Trp Ala Ala Ala 
        275                 280                 285             


Lys Asp Gly Lys Leu His Phe Gly Ile Asp Pro Asp Asp Thr Thr Ile 
    290                 295                 300                 


Thr Asp Leu Pro 
305             


<210> 7289
<211> 142
<212> PRT
<213> Homo sapiens

<400> 7289
Met Ser Leu His Gly Lys Arg Lys Glu Ile Tyr Lys Tyr Glu Ala Pro 
1               5                   10                  15      


Trp Thr Val Tyr Ala Met Asn Trp Ser Val Arg Pro Asp Lys Arg Phe 
            20                  25                  30          


Arg Leu Ala Leu Gly Ser Phe Val Glu Glu Tyr Asn Asn Lys Val Val 
        35                  40                  45              


Ile Leu Asp Val Arg Val Pro Cys Thr Pro Val Ala Arg Leu Asn Asn 
    50                  55                  60                  


His Arg Ala Cys Val Asn Gly Ile Ala Trp Ala Pro His Ser Ser Cys 
65                  70                  75                  80  


His Ile Cys Thr Ala Ala Asp Asp His Gln Ala Leu Ile Trp Asp Ile 
                85                  90                  95      


Gln Gln Met Pro Arg Ala Ile Glu Asp Pro Ile Leu Ala Tyr Thr Ala 
            100                 105                 110         


Glu Gly Glu Ile Asn Asn Val Gln Trp Ala Ser Thr Gln Pro Asp Trp 
        115                 120                 125             


Ile Ala Ile Cys Tyr Asn Asn Cys Leu Glu Ile Leu Arg Val 
    130                 135                 140         


<210> 7290
<211> 410
<212> PRT
<213> Homo sapiens

<400> 7290
Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro 
            20                  25                  30          


Ala Val Ser Ser Met Gln Gly Phe Gln Ile Asn Phe Cys Glu Lys Ala 
        35                  40                  45              


Gln Ser Lys Arg Lys Ala Leu Lys Leu Asn Phe Ala Asn Pro Pro Phe 
    50                  55                  60                  


Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn Pro Thr Gly Val Gln 
65                  70                  75                  80  


Asn Pro His Ile Glu Arg Leu Arg Thr His Ser Ile Glu Ser Ser Gly 
                85                  90                  95      


Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp Phe Thr Ala Glu Asp 
            100                 105                 110         


Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala Tyr Gly Ser Val Asn 
        115                 120                 125             


Lys Met Val His Lys Pro Ser Gly Gln Ile Met Ala Val Lys Arg Ile 
    130                 135                 140                 


Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln Leu Leu Met Asp Leu 
145                 150                 155                 160 


Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr Ile Val Gln Phe Tyr 
                165                 170                 175     


Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile Cys Met Glu Leu Met 
            180                 185                 190         


Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val Tyr Ser Val Leu Asp 
        195                 200                 205             


Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile Thr Leu Ala Thr Val 
    210                 215                 220                 


Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys Ile Ile His Arg Asp 
225                 230                 235                 240 


Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser Gly Asn Ile Lys Leu 
                245                 250                 255     


Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp Ser Ile Ala Lys Thr 
            260                 265                 270         


Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro Glu Arg Ile Asp Pro 
        275                 280                 285             


Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser Asp Val Trp Ser Leu 
    290                 295                 300                 


Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg Phe Pro Tyr Pro Lys 
305                 310                 315                 320 


Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val Val Lys Gly Asp Pro 
                325                 330                 335     


Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe Ser Pro Ser Phe Ile 
            340                 345                 350         


Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu Ser Lys Arg Pro Lys 
        355                 360                 365             


Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu Met Tyr Glu Glu Arg 
    370                 375                 380                 


Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile Leu Asp Gln Met Pro 
385                 390                 395                 400 


Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
                405                 410 


<210> 7291
<211> 228
<212> PRT
<213> Homo sapiens

<400> 7291
Met Gln Leu Ala Val Val Ser Glu Glu Gln Asp Gln Asn Leu Asn Arg 
1               5                   10                  15      


Leu Ile Cys Trp Ile Leu Met Gln Phe Ile Tyr Ile Ser Ser Asp Tyr 
            20                  25                  30          


Val Phe Asp Gly Thr Asn Pro Pro Tyr Arg Glu Glu Asp Ile Pro Ala 
        35                  40                  45              


Pro Leu Asn Leu Tyr Gly Lys Thr Lys Leu Asp Gly Glu Lys Ala Val 
    50                  55                  60                  


Leu Glu Asn Asn Leu Gly Ala Ala Val Leu Arg Ile Pro Ile Leu Tyr 
65                  70                  75                  80  


Gly Glu Val Glu Lys Leu Glu Glu Ser Ala Val Thr Val Met Phe Asp 
                85                  90                  95      


Lys Val Gln Phe Ser Asn Lys Ser Ala Asn Met Asp His Trp Gln Gln 
            100                 105                 110         


Arg Phe Pro Thr His Val Lys Asp Val Ala Thr Val Cys Arg Gln Leu 
        115                 120                 125             


Ala Glu Lys Arg Met Leu Asp Pro Ser Ile Lys Gly Thr Phe His Trp 
    130                 135                 140                 


Ser Gly Asn Glu Gln Met Thr Lys Tyr Glu Met Ala Cys Ala Ile Ala 
145                 150                 155                 160 


Asp Ala Phe Asn Leu Pro Ser Ser His Leu Arg Pro Ile Thr Asp Ser 
                165                 170                 175     


Pro Val Leu Gly Ala Gln Arg Pro Arg Asn Ala Gln Leu Asp Cys Ser 
            180                 185                 190         


Lys Leu Glu Thr Leu Gly Ile Gly Gln Arg Thr Pro Phe Arg Ile Gly 
        195                 200                 205             


Ile Lys Glu Ser Leu Trp Pro Phe Leu Ile Asp Lys Arg Trp Arg Gln 
    210                 215                 220                 


Thr Val Phe His 
225             


<210> 7292
<211> 366
<212> PRT
<213> Homo sapiens

<400> 7292
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr Thr Gly Tyr Gln Leu 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr Thr Gly Tyr Gln Leu 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Ala Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Phe His Val Tyr Asn Tyr Gln Met Pro 
                325                 330                 335     


Pro Gln Cys Pro Val Gly Glu Gln Arg Arg Asn Leu Trp Thr Glu Ala 
            340                 345                 350         


Tyr Lys Trp Trp Tyr Leu Val Cys Leu Ile Gln Arg Arg Asp 
        355                 360                 365     


<210> 7293
<211> 101
<212> PRT
<213> Homo sapiens

<400> 7293
Met Ala Ser Ala Gly Thr Gln His Tyr Ser Ile Gly Leu Arg Gln Lys 
1               5                   10                  15      


Asn Ser Phe Lys Gln Ser Gly Pro Ser Gly Thr Val Pro Ala Thr Pro 
            20                  25                  30          


Pro Glu Lys Pro Ser Glu Gly Arg Val Trp Pro Gln Ala His Gln Gln 
        35                  40                  45              


Val Lys Pro Ile Trp Lys Leu Glu Lys Lys Gln Val Glu Thr Leu Ser 
    50                  55                  60                  


Ala Gly Leu Gly Pro Gly Leu Leu Gly Val Pro Pro Gln Pro Ala Tyr 
65                  70                  75                  80  


Phe Phe Cys Pro Ser Thr Leu Cys Ser Ser Gly Thr Thr Ala Val Ile 
                85                  90                  95      


Ala Gly His Ser Ser 
            100     


<210> 7294
<211> 706
<212> PRT
<213> Homo sapiens

<400> 7294
Met Ile Asp Ser Val Lys Leu Arg Arg Asp Ser Ala Ala Asp Phe Phe 
1               5                   10                  15      


Ser His Tyr Glu Tyr Leu Cys Ala Leu Gln Asn Ser Val Pro Leu Pro 
            20                  25                  30          


Ala Val Arg Ala Cys Leu Arg Glu Gly Val Leu Asp Phe Asn Ala Asp 
        35                  40                  45              


Arg Leu Arg Gly Val Asp Trp Ala Pro Leu Leu Ser Thr Leu Lys Ile 
    50                  55                  60                  


Asn Lys Asp Leu Pro Leu Val Ser Ile Lys Ser Phe Phe Gln Pro Trp 
65                  70                  75                  80  


Leu Gly Asp Thr Gly Ser Asp Met Asn Lys Phe Cys Arg Ser Arg Val 
                85                  90                  95      


Pro Ala Ile Arg Tyr Lys Asp Val Thr Phe Gln Leu Cys Lys Ala Leu 
            100                 105                 110         


Lys Gly Cys Leu Ser Ile Ser Ser Val Leu Lys Asn Leu Glu Leu Asn 
        115                 120                 125             


Gly Leu Ile Leu Arg Glu Arg Asp Leu Thr Ile Leu Ala Lys Gly Leu 
    130                 135                 140                 


Asn Lys Ser Ala Ser Leu Val His Leu Ser Leu Ala Asn Cys Pro Ile 
145                 150                 155                 160 


Gly Asp Gly Gly Leu Glu Ile Ile Cys Gln Gly Ile Lys Ser Ser Ile 
                165                 170                 175     


Thr Leu Lys Thr Val Asn Phe Thr Gly Cys Asn Leu Thr Trp Gln Gly 
            180                 185                 190         


Ala Asp His Met Ala Lys Ile Leu Lys Tyr Gln Thr Met Arg Arg His 
        195                 200                 205             


Glu Glu Thr Trp Ala Glu Ser Leu Arg Tyr Arg Arg Pro Asp Leu Asp 
    210                 215                 220                 


Cys Met Ala Gly Leu Arg Arg Ile Thr Leu Asn Cys Asn Thr Leu Ile 
225                 230                 235                 240 


Gly Asp Leu Gly Ala Cys Ala Phe Ala Asp Ser Leu Ser Glu Asp Leu 
                245                 250                 255     


Trp Leu Arg Ala Leu Asp Leu Gln Gln Cys Gly Leu Thr Asn Glu Gly 
            260                 265                 270         


Ala Lys Ala Leu Leu Glu Ala Leu Glu Thr Asn Thr Thr Leu Val Val 
        275                 280                 285             


Leu Asp Ile Arg Lys Asn Pro Leu Ile Asp His Ser Met Met Lys Ala 
    290                 295                 300                 


Val Ile Lys Lys Val Leu Gln Asn Gly Arg Ser Ala Lys Ser Glu Tyr 
305                 310                 315                 320 


Gln Trp Ile Thr Ser Pro Ser Val Lys Glu Pro Ser Lys Thr Ala Lys 
                325                 330                 335     


Gln Lys Arg Arg Thr Ile Ile Leu Gly Ser Gly His Lys Gly Lys Ala 
            340                 345                 350         


Thr Ile Arg Ile Val Gly Leu Ala Thr Lys Lys Pro Val Ser Ser Gly 
        355                 360                 365             


Arg Lys His Ser Leu Gly Lys Glu Tyr Tyr Ala Pro Ala Pro Leu Pro 
    370                 375                 380                 


Pro Gly Val Ser Gly Phe Leu Pro Trp Arg Thr Ala Glu Arg Ala Lys 
385                 390                 395                 400 


Arg His Arg Gly Phe Pro Leu Ile Lys Thr Arg Asp Ile Cys Asn Gln 
                405                 410                 415     


Leu Gln Gln Pro Gly Phe Pro Val Thr Val Thr Val Glu Ser Pro Ser 
            420                 425                 430         


Ser Ser Glu Val Glu Glu Val Asp Asp Ser Ser Glu Ser Val His Glu 
        435                 440                 445             


Val Pro Glu Lys Thr Ser Ile Glu Gln Glu Ala Leu Gln Glu Lys Leu 
    450                 455                 460                 


Glu Glu Cys Leu Lys Gln Leu Lys Glu Glu Arg Val Ile Arg Leu Lys 
465                 470                 475                 480 


Val Asp Lys Arg Val Ser Glu Leu Glu His Glu Asn Ala Gln Leu Arg 
                485                 490                 495     


Asn Ile Asn Phe Ser Leu Ser Glu Ala Leu His Ala Gln Ser Leu Thr 
            500                 505                 510         


Asn Met Ile Leu Asp Asp Glu Gly Val Leu Gly Ser Ile Glu Asn Ser 
        515                 520                 525             


Phe Gln Lys Phe His Ala Phe Leu Asp Leu Leu Lys Asp Ala Gly Leu 
    530                 535                 540                 


Gly Gln Leu Ala Thr Met Ala Gly Ile Asp Gln Ser Asp Phe Gln Leu 
545                 550                 555                 560 


Leu Gly His Pro Gln Met Thr Ser Thr Val Ser Asn Pro Pro Lys Glu 
                565                 570                 575     


Glu Lys Lys Ala Leu Glu Asp Glu Lys Pro Glu Pro Lys Gln Asn Ala 
            580                 585                 590         


Leu Gly Gln Met Gln Asn Ile Gln Phe Gln Lys Ile Thr Gly Asp Ala 
        595                 600                 605             


Arg Ile Pro Leu Pro Leu Asp Ser Phe Pro Val Pro Val Ser Thr Pro 
    610                 615                 620                 


Glu Gly Leu Gly Thr Ser Ser Asn Asn Leu Gly Val Pro Ala Thr Glu 
625                 630                 635                 640 


Gln Arg Gln Glu Ser Phe Glu Gly Phe Ile Ala Arg Met Cys Ser Pro 
                645                 650                 655     


Ser Pro Asp Ala Thr Ser Gly Thr Gly Ser Gln Arg Lys Glu Glu Glu 
            660                 665                 670         


Leu Ser Arg Asn Ser Arg Ser Ser Ser Glu Lys Lys Thr Lys Thr Gly 
        675                 680                 685             


Glu Tyr Thr Lys Lys His Ser Asp Lys Gln His Pro Gly Lys Asp Leu 
    690                 695                 700                 


His Ser 
705     


<210> 7295
<211> 643
<212> PRT
<213> Homo sapiens

<400> 7295
Met Ala Cys Gln Gln Ser Arg Tyr His Ser Phe Ser Ser Ala Ser Arg 
1               5                   10                  15      


Leu Gln Pro Arg Pro Ser Gly Val Thr Ile Asp Glu Ser Phe Leu Thr 
            20                  25                  30          


Glu Asp Lys Ser Thr Gln Asn Arg Lys Leu Leu Gln Lys Arg Arg Thr 
        35                  40                  45              


Leu Glu Leu Pro Ala Ala Pro Leu Ser His Cys Gln Ala Pro Val Leu 
    50                  55                  60                  


Gly Gly Thr Gly Lys Leu Pro Thr Gln Gly Ala Pro Pro Ala Gly Pro 
65                  70                  75                  80  


Gly His Arg Phe His Pro Gly Thr Lys Ala Ala Ala His Gln Arg Glu 
                85                  90                  95      


Lys Ile Arg Ala Leu Glu Pro Leu Lys Ala Lys Leu Val Thr Val Asn 
            100                 105                 110         


Glu Asp Cys Asn Glu Arg Ile Leu Ala Met Arg Ala Glu Glu Lys Tyr 
        115                 120                 125             


Glu Ile Ser Leu Leu Lys Lys Glu Lys Met Asn Leu Leu Lys Leu Ile 
    130                 135                 140                 


Asp Lys Lys Asn Glu Glu Lys Ile Ser Leu Gln Ser Glu Val Thr Lys 
145                 150                 155                 160 


Leu Arg Lys Asn Leu Ala Glu Glu Tyr Leu His Tyr Leu Ser Glu Arg 
                165                 170                 175     


Asp Ala Cys Lys Ile Leu Ile Ala Asp Leu Asn Glu Leu Arg Tyr Gln 
            180                 185                 190         


Arg Glu Asp Met Ser Leu Ala Gln Ser Pro Gly Ile Trp Gly Glu Asp 
        195                 200                 205             


Pro Val Lys Leu Thr Leu Ala Leu Lys Met Thr Arg Gln Asp Leu Thr 
    210                 215                 220                 


Arg Thr Gln Met Glu Leu Asn Asn Met Lys Ala Asn Phe Gly Asp Val 
225                 230                 235                 240 


Val Pro Arg Arg Asp Phe Glu Met Gln Glu Lys Thr Asn Lys Asp Leu 
                245                 250                 255     


Gln Glu Gln Leu Asp Thr Leu Arg Ala Ser Tyr Glu Glu Val Arg Lys 
            260                 265                 270         


Glu His Glu Ile Leu Met Gln Leu His Met Ser Thr Leu Lys Glu Arg 
        275                 280                 285             


Asp Gln Phe Phe Ser Glu Leu Gln Glu Ile Gln Arg Thr Ser Thr Pro 
    290                 295                 300                 


Arg Pro Asp Trp Thr Lys Cys Lys Asp Val Val Ala Gly Gly Pro Glu 
305                 310                 315                 320 


Arg Trp Gln Met Leu Ala Glu Gly Lys Asn Ser Asp Gln Leu Val Asp 
                325                 330                 335     


Val Leu Leu Glu Glu Ile Gly Ser Gly Leu Leu Arg Glu Lys Asp Phe 
            340                 345                 350         


Phe Pro Gly Leu Gly Tyr Gly Glu Ala Ile Pro Ala Phe Leu Arg Phe 
        355                 360                 365             


Asp Gly Leu Val Glu Asn Lys Lys Pro Ser Lys Lys Asp Val Val Asn 
    370                 375                 380                 


Leu Leu Lys Asp Ala Trp Lys Glu Arg Leu Ala Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Thr Phe Pro Asp Phe Phe Phe Asn Phe Leu Glu His Arg Phe Gly Pro 
                405                 410                 415     


Ser Asp Ala Met Ala Trp Ala Tyr Thr Ile Phe Glu Asn Ile Lys Ile 
            420                 425                 430         


Phe His Ser Asn Glu Val Met Ser Gln Phe Tyr Ala Val Leu Met Gly 
        435                 440                 445             


Lys Arg Ser Glu Asn Val Tyr Val Thr Gln Lys Glu Thr Val Ala Gln 
    450                 455                 460                 


Leu Leu Lys Glu Met Thr Asn Ala Asp Ser Gln Asn Glu Gly Leu Leu 
465                 470                 475                 480 


Thr Met Glu Gln Phe Asn Thr Val Leu Lys Ser Thr Phe Pro Leu Lys 
                485                 490                 495     


Thr Glu Glu Gln Ile Gln Glu Leu Met Glu Ala Gly Gly Trp His Pro 
            500                 505                 510         


Ser Ser Ser Asn Ala Asp Leu Leu Asn Tyr Arg Ser Leu Phe Met Glu 
        515                 520                 525             


Asp Glu Glu Gly Gln Ser Glu Pro Phe Val Gln Lys Leu Trp Glu Gln 
    530                 535                 540                 


Tyr Met Asp Glu Lys Asp Glu Tyr Leu Gln Gln Leu Lys Gln Glu Leu 
545                 550                 555                 560 


Gly Ile Glu Leu His Glu Glu Val Thr Leu Pro Lys Leu Arg Gly Gly 
                565                 570                 575     


Leu Met Thr Ile Asp Pro Ser Leu Asp Lys Gln Thr Val Asn Thr Tyr 
            580                 585                 590         


Met Ser Gln Ala Phe Gln Leu Pro Glu Ser Glu Met Pro Glu Glu Gly 
        595                 600                 605             


Asp Glu Lys Glu Glu Ala Val Val Glu Ile Leu Gln Thr Ala Leu Glu 
    610                 615                 620                 


Arg Leu Gln Val Ile Asp Ile Arg Arg Val Gly Pro Arg Glu Pro Glu 
625                 630                 635                 640 


Pro Ala Ser 
            


<210> 7296
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7296
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 7297
<211> 312
<212> PRT
<213> Homo sapiens

<400> 7297
Met Ala Gln Pro Tyr Pro Pro Ala Gln Tyr Pro Pro Pro Pro Gln Asn 
1               5                   10                  15      


Gly Ile Pro Ala Glu Tyr Ala Pro Pro Pro Pro His Pro Thr Gln Asp 
            20                  25                  30          


Tyr Ser Gly Gln Thr Pro Val Pro Thr Glu His Gly Met Thr Leu Tyr 
        35                  40                  45              


Thr Pro Ala Gln Thr His Pro Glu Gln Pro Gly Ser Glu Ala Ser Thr 
    50                  55                  60                  


Gln Pro Ile Ala Gly Thr Gln Thr Val Pro Gln Thr Asp Glu Ala Ala 
65                  70                  75                  80  


Gln Thr Asp Ser Gln Pro Leu His Pro Ser Asp Pro Thr Glu Lys Gln 
                85                  90                  95      


Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp 
            100                 105                 110         


Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val 
        115                 120                 125             


Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr 
    130                 135                 140                 


Phe Glu Thr Ser Ser Asp Ala Asp Arg Ala Arg Glu Lys Leu Asn Gly 
145                 150                 155                 160 


Thr Ile Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg 
                165                 170                 175     


Val Met Thr Asn Lys Lys Thr Gly Asn Pro Tyr Thr Asn Gly Trp Lys 
            180                 185                 190         


Leu Asn Pro Val Val Gly Ala Val Tyr Gly Pro Glu Phe Tyr Ala Val 
        195                 200                 205             


Thr Gly Phe Pro Tyr Pro Thr Thr Gly Thr Ala Val Ala Tyr Arg Gly 
    210                 215                 220                 


Ala His Leu Arg Gly Arg Gly Arg Ala Val Tyr Asn Thr Phe Arg Ala 
225                 230                 235                 240 


Ala Pro Pro Pro Pro Pro Ile Pro Thr Tyr Gly Ala Val Val Tyr Gln 
                245                 250                 255     


Asp Gly Phe Tyr Gly Ala Glu Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg 
            260                 265                 270         


Tyr Ala Gln Pro Ala Ala Ala Ala Ala Ala Tyr Ser Asp Ser Tyr Gly 
        275                 280                 285             


Arg Val Tyr Ala Ala Ala Asp Pro Tyr His His Thr Ile Gly Pro Ala 
    290                 295                 300                 


Ala Thr Tyr Ser Ile Gly Thr Met 
305                 310         


<210> 7298
<211> 99
<212> PRT
<213> Homo sapiens

<400> 7298
Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr Asp Gln Asp Leu Leu 
1               5                   10                  15      


Leu Met Gln Glu Gly Met Pro Met Arg Lys Val Arg Ser Lys Ser Trp 
            20                  25                  30          


Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp Gly Met Thr Val Trp 
        35                  40                  45              


His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro Ser Phe Ser Ile Ser 
    50                  55                  60                  


Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser Glu Leu Leu Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe Thr Ile Val Phe His 
                85                  90                  95      


Gly Arg Arg 
            


<210> 7299
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7299
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7300
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7300
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Glu Lys Ile Leu Asn His Leu Ser Thr 
65                  70                  75                  80  


Leu Arg Arg Asp Arg Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu 
                85                  90                  95      


Ala Asp Ile Leu Ala Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr 
            100                 105                 110         


Ile Val Ala Glu Phe Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu 
        115                 120                 125             


Glu His Leu Leu Glu Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu 
    130                 135                 140                 


Gly Arg Glu Lys Phe Lys Ser Arg Gly Val Gly Glu Leu Ala Arg 
145                 150                 155                 


<210> 7301
<211> 192
<212> PRT
<213> Homo sapiens

<400> 7301
Met Gly Lys Gly Cys Lys Val Val Val Cys Gly Leu Leu Ser Val Gly 
1               5                   10                  15      


Lys Thr Ala Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Thr Ile Gly 
            20                  25                  30          


Met Glu Asp Cys Glu Thr Met Glu Asp Val Tyr Met Ala Ser Val Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Lys Glu Gln Leu His Leu Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Gln Glu Gly Val Glu Leu Pro Lys His Tyr Phe Ser Phe Ala Asp 
65                  70                  75                  80  


Gly Phe Val Leu Val Tyr Ser Val Asn Asn Leu Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Phe Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Ala Ile Val Val Leu Gly Asn Lys Ile Asp Leu Ser Glu Gln Arg 
        115                 120                 125             


Gln Val Asp Ala Glu Val Ala Gln Gln Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Arg Leu Trp Glu Val Thr Val Thr Asp Arg Lys Thr Leu Ile Glu Pro 
145                 150                 155                 160 


Phe Thr Leu Leu Ala Ser Lys Leu Ser Gln Pro Gln Ser Lys Ser Ser 
                165                 170                 175     


Phe Pro Leu Pro Gly Arg Lys Asn Lys Gly Asn Ser Asn Ser Glu Asn 
            180                 185                 190         


<210> 7302
<211> 102
<212> PRT
<213> Homo sapiens

<400> 7302
Met His Asn Arg Ser Gln Gly Phe Phe Phe Ser Ser Cys His Pro Gln 
1               5                   10                  15      


Asn His Val Ser Tyr Gly Cys Gln Ser Pro Ser Phe Ile Phe Cys Arg 
            20                  25                  30          


Cys Gln Ser Leu Asn Phe Val Ser Arg Thr Cys Tyr Pro Leu Ser Tyr 
        35                  40                  45              


Phe Ser Tyr Gly Asn Gln Thr Ile Gly Ser Ile Ser Asn Ser Phe Arg 
    50                  55                  60                  


Ser Leu Asn Tyr Val Ser His Ser Phe Gln Pro Ile Ser Phe Met His 
65                  70                  75                  80  


Ser Ser Phe Gln Pro Ala Cys Ser Asp Phe Val Gly Trp Gln Ser Pro 
                85                  90                  95      


Phe Leu Arg Arg Thr Cys 
            100         


<210> 7303
<211> 240
<212> PRT
<213> Homo sapiens

<400> 7303
Met Asp Leu Val Arg Leu Gly Leu Glu Arg Gly Glu Thr Ala Lys Glu 
1               5                   10                  15      


Ala Leu Asp Val Ile Val Ser Leu Leu Glu Glu His Gly Gln Gly Gly 
            20                  25                  30          


Asn Tyr Phe Glu Asp Ala Asn Ser Cys His Ser Phe Gln Ser Ala Tyr 
        35                  40                  45              


Leu Ile Val Asp Arg Asp Glu Ala Trp Val Leu Glu Thr Ile Gly Lys 
    50                  55                  60                  


Tyr Trp Ala Ala Glu Lys Val Thr Glu Ser Ile Thr Val Gln Thr Met 
65                  70                  75                  80  


Met Asn Thr Leu Arg Asp Lys Ala Ser Gly Val Cys Ile Asp Ser Glu 
                85                  90                  95      


Phe Phe Leu Thr Thr Ala Ser Gly Val Ser Val Leu Pro Gln Asn Arg 
            100                 105                 110         


Ser Ser Pro Cys Ile His Tyr Phe Thr Gly Thr Pro Asp Pro Ser Arg 
        115                 120                 125             


Ser Ile Phe Lys Pro Phe Ile Phe Val Asp Asp Val Lys Leu Val Pro 
    130                 135                 140                 


Lys Thr Gln Ser Pro Cys Phe Gly Asp Asp Asp Pro Ala Lys Lys Glu 
145                 150                 155                 160 


Pro Arg Phe Gln Glu Lys Pro Asp Arg Arg His Glu Leu Tyr Lys Ala 
                165                 170                 175     


His Glu Trp Ala Arg Ala Ile Ile Glu Ser Asp Gln Glu Gln Gly Arg 
            180                 185                 190         


Lys Leu Arg Ser Thr Met Leu Glu Leu Glu Lys Gln Gly Leu Glu Ala 
        195                 200                 205             


Met Glu Glu Ile Leu Thr Ser Ser Glu Pro Leu Asp Pro Ala Glu Val 
    210                 215                 220                 


Gly Asp Leu Phe Tyr Asp Cys Val Asp Thr Glu Ile Lys Phe Phe Lys 
225                 230                 235                 240 


<210> 7304
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7304
Xaa Arg Glu Glu Asp Ile Tyr Gln Phe Ala Tyr Cys Tyr Pro Tyr Thr 
1               5                   10                  15      


Tyr Thr Arg Phe Gln His Tyr Leu Asp Ser Leu Gln Lys Arg Asn Met 
            20                  25                  30          


Asp Tyr Phe Phe Arg Glu Gln Leu Gly Gln Ser Val Gln Gln Arg Lys 
        35                  40                  45              


Leu Asp Leu Leu Thr Ile Thr Ser Pro Asp Asn Leu Arg Glu Gly Ala 
    50                  55                  60                  


Glu Gln Lys Val Val Phe Ile Thr Gly Arg Val His Pro Gly Glu Thr 
65                  70                  75                  80  


Pro Ser Ser Phe Val Cys Gln Gly Ile Ile Asp Phe Leu Val Ser Gln 
                85                  90                  95      


His Pro Ile Ala Cys Val Leu Arg Glu Tyr Leu Val Phe Lys Ile Ala 
            100                 105                 110         


Pro Met Leu Asn Pro Asp Gly Val Tyr Leu Gly Asn Tyr Arg Cys Ser 
        115                 120                 125             


Leu Met Gly Phe Asp Leu Asn Arg His Trp Leu Asp Pro Ser Pro Trp 
    130                 135                 140                 


Val His Pro Thr Leu His Gly Val Lys Gln Leu Ile Val Gln Met Tyr 
145                 150                 155                 160 


Asn Asp Pro Lys Thr Ser Leu Glu Phe Tyr Ile Asp Ile His Ala His 
                165                 170                 175     


Ser Thr Met Met Asn Gly Phe Met Tyr Gly Asn Ile Phe Glu Asp Glu 
            180                 185                 190         


Glu Arg Phe Gln Arg Gln Ala Ile Phe Pro Lys Leu Leu Cys Gln Asn 
        195                 200                 205             


Ala Glu Asp Phe Ser Tyr Ser Ser Thr Ser Phe Asn Arg Asp Ala Val 
    210                 215                 220                 


Lys Ala Gly Thr Gly Arg Arg Phe Leu Gly Gly Leu Leu Asp His Thr 
225                 230                 235                 240 


Ser Tyr Cys Tyr Thr Leu Glu Val Ser Phe Tyr Ser Tyr Ile Ile Ser 
                245                 250                 255     


Gly Thr Thr Ala Ala Val Pro Tyr Thr Glu Glu Ala Cys Ile Leu Ser 
            260                 265                 270         


Pro His Pro Ala Leu Gly Gln Pro Ser Ser Ser Arg Glu Tyr Pro Ser 
        275                 280                 285             


Leu Thr Gly Gln Glu Leu Gly Pro Gln Leu Arg 
    290                 295                 


<210> 7305
<211> 346
<212> PRT
<213> Homo sapiens

<400> 7305
Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp 
    290                 295                 300                 


Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr 
305                 310                 315                 320 


Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys 
                325                 330                 335     


Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345     


<210> 7306
<211> 131
<212> PRT
<213> Homo sapiens

<400> 7306
Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210> 7307
<211> 101
<212> PRT
<213> Homo sapiens

<400> 7307
Met Pro Phe Phe Gly Asn Thr Phe Ser Pro Lys Lys Thr Pro Pro Arg 
1               5                   10                  15      


Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Thr Arg 
            20                  25                  30          


Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Thr Met Asn Leu Ala 
        35                  40                  45              


Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala Glu Thr Gly 
    50                  55                  60                  


Val Ser Gly Gly Val Asp Arg Arg Glu Val Gln Arg Leu Arg Arg Arg 
65                  70                  75                  80  


Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp 
                85                  90                  95      


Ile Leu Leu Asp Met 
            100     


<210> 7308
<211> 130
<212> PRT
<213> Homo sapiens

<400> 7308
Met Asp Ile Ser Lys Gly Leu Pro Gly Met Gln Gly Gly Leu His Ile 
1               5                   10                  15      


Trp Ile Ser Glu Asn Arg Lys Met Val Pro Val Pro Glu Gly Ala Tyr 
            20                  25                  30          


Gly Asn Phe Phe Glu Glu His Cys Tyr Val Ile Leu His Val Pro Gln 
        35                  40                  45              


Ser Pro Lys Ala Thr Gln Gly Ala Ser Ser Asp Leu His Tyr Trp Val 
    50                  55                  60                  


Gly Lys Gln Ala Gly Ala Glu Ala Gln Gly Ala Ala Glu Ala Phe Gln 
65                  70                  75                  80  


Gln Arg Leu Gln Asp Glu Leu Gly Gly Gln Thr Val Leu His Arg Glu 
                85                  90                  95      


Ala Gln Gly His Glu Ser Asp Cys Phe Cys Ser Tyr Phe Arg Pro Gly 
            100                 105                 110         


Ile Ile Tyr Arg Lys Gly Gly Leu Ala Ser Asp Leu Lys His Val Glu 
        115                 120                 125             


Thr Asn 
    130 


<210> 7309
<211> 16
<212> PRT
<213> Homo sapiens

<400> 7309
Met Cys Thr Ser Glu Thr Phe Gln Ala Leu Asp Thr Phe Glu Ala Arg 
1               5                   10                  15      


<210> 7310
<211> 1850
<212> PRT
<213> Homo sapiens

<400> 7310
Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      


Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          


Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              


Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  


Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  


Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      


Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         


Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             


Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 


Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 


Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     


Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         


Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        195                 200                 205             


Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    210                 215                 220                 


Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                245                 250                 255     


Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            260                 265                 270         


Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        275                 280                 285             


Pro Val Ser Ser Lys Phe Gln Lys Arg Lys Met Leu Arg Leu Ser Gln 
    290                 295                 300                 


Asp Val Lys Gly Tyr Ser Phe Ile Lys Asp Leu Gln Trp Ile Gln Val 
305                 310                 315                 320 


Ser Asp Ser Lys Glu Ala Tyr Arg Leu Leu Lys Leu Gly Ile Lys His 
                325                 330                 335     


Gln Ser Val Ala Phe Thr Lys Leu Asn Asn Ala Ser Ser Arg Ser His 
            340                 345                 350         


Ser Ile Phe Thr Val Lys Ile Leu Gln Ile Glu Asp Ser Glu Met Ser 
        355                 360                 365             


Arg Val Ile Arg Val Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser 
    370                 375                 380                 


Glu Arg Thr Met Lys Thr Gln Asn Glu Gly Glu Arg Leu Arg Glu Thr 
385                 390                 395                 400 


Gly Asn Ile Asn Thr Ser Leu Leu Thr Leu Gly Lys Cys Ile Asn Val 
                405                 410                 415     


Leu Lys Asn Ser Glu Lys Ser Lys Phe Gln Gln His Val Pro Phe Arg 
            420                 425                 430         


Glu Ser Lys Leu Thr His Tyr Phe Gln Ser Phe Phe Asn Gly Lys Gly 
        435                 440                 445             


Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala Tyr Asp 
    450                 455                 460                 


Glu Thr Leu Asn Val Leu Lys Phe Ser Ala Ile Ala Gln Lys Val Cys 
465                 470                 475                 480 


Val Pro Asp Thr Leu Asn Ser Ser Gln Glu Lys Leu Phe Gly Pro Val 
                485                 490                 495     


Lys Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys Ile 
            500                 505                 510         


Leu Asn Val Lys Arg Ala Thr Ile Ser Trp Glu Asn Ser Leu Glu Asp 
        515                 520                 525             


Leu Met Glu Asp Glu Asp Leu Val Glu Glu Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


Thr Gln Asn Val Glu Thr Lys Leu Leu Asp Glu Asp Leu Asp Lys Thr 
545                 550                 555                 560 


Leu Glu Glu Asn Lys Ala Phe Ile Ser His Glu Glu Lys Arg Lys Leu 
                565                 570                 575     


Leu Asp Leu Ile Glu Asp Leu Lys Lys Lys Leu Ile Asn Glu Lys Lys 
            580                 585                 590         


Glu Lys Leu Thr Leu Glu Phe Lys Ile Arg Glu Glu Val Thr Gln Glu 
        595                 600                 605             


Phe Thr Gln Tyr Trp Ala Gln Arg Glu Ala Asp Phe Lys Glu Thr Leu 
    610                 615                 620                 


Leu Gln Glu Arg Glu Ile Leu Glu Glu Asn Ala Glu Arg Arg Leu Ala 
625                 630                 635                 640 


Ile Phe Lys Asp Leu Val Gly Lys Cys Asp Thr Arg Glu Glu Ala Ala 
                645                 650                 655     


Lys Asp Ile Cys Ala Thr Lys Val Glu Thr Glu Glu Thr His Asn Tyr 
            660                 665                 670         


Val Gly Phe Glu Asp Ile Ile Asp Ser Leu Gln Asp Asn Val Ala Asp 
        675                 680                 685             


Ile Lys Lys Gln Ala Glu Ile Ala His Leu Tyr Ile Ala Ser Leu Pro 
    690                 695                 700                 


Asp Pro Gln Glu Ala Thr Ala Cys Leu Glu Leu Lys Phe Asn Gln Ile 
705                 710                 715                 720 


Lys Ala Glu Leu Ala Lys Thr Lys Gly Glu Leu Ile Lys Thr Lys Glu 
                725                 730                 735     


Glu Leu Lys Lys Arg Glu Asn Glu Ser Asp Ser Leu Ile Gln Glu Leu 
            740                 745                 750         


Glu Thr Ser Asn Lys Lys Ile Ile Thr Gln Asn Gln Arg Ile Lys Glu 
        755                 760                 765             


Leu Ile Asn Ile Ile Asp Gln Lys Glu Asp Thr Ile Asn Glu Phe Gln 
    770                 775                 780                 


Asn Leu Lys Ser His Met Glu Asn Thr Phe Lys Cys Asn Asp Lys Ala 
785                 790                 795                 800 


Asp Thr Ser Ser Leu Ile Ile Asn Asn Lys Leu Ile Cys Asn Glu Thr 
                805                 810                 815     


Val Glu Val Pro Lys Asp Ser Lys Ser Lys Ile Cys Ser Glu Arg Lys 
            820                 825                 830         


Arg Val Asn Glu Asn Glu Leu Gln Gln Asp Glu Pro Pro Ala Lys Lys 
        835                 840                 845             


Gly Thr Thr Ser Ala Ala Ser Ser Arg Arg Leu Arg Lys Leu Ile Ser 
    850                 855                 860                 


Lys Pro Val Asn Arg Thr Arg Gln Thr Glu Gly His Ser Leu Val Ser 
865                 870                 875                 880 


Ile His Val Ser Ser Ala Ile Thr Glu Asp Gln Lys Lys Ser Glu Glu 
                885                 890                 895     


Val Arg Pro Asn Ile Ala Glu Ile Glu Asp Ile Arg Val Leu Gln Glu 
            900                 905                 910         


Asn Asn Glu Gly Leu Arg Ala Phe Leu Leu Thr Ile Glu Asn Glu Leu 
        915                 920                 925             


Lys Asn Glu Lys Glu Glu Lys Ala Glu Leu Asn Lys Gln Ile Val His 
    930                 935                 940                 


Phe Gln Gln Glu Leu Ser Leu Ser Glu Lys Lys Asn Leu Thr Leu Ser 
945                 950                 955                 960 


Lys Glu Val Gln Gln Ile Gln Ser Asn Tyr Asp Ile Ala Ile Ala Glu 
                965                 970                 975     


Leu His Val Gln Lys Ser Lys Asn Gln Glu Gln Glu Glu Lys Ile Met 
            980                 985                 990         


Lys Leu Ser Asn Glu Ile Glu Thr  Ala Thr Arg Ser Ile  Thr Asn Asn 
        995                 1000                 1005             


Val Ser  Gln Ile Lys Leu Met  His Thr Lys Ile Asp  Glu Leu Arg 
    1010                 1015                 1020             


Thr Leu  Asp Ser Val Ser Gln  Ile Ser Asn Ile Asp  Leu Leu Asn 
    1025                 1030                 1035             


Leu Arg  Asp Leu Ser Asn Gly  Ser Glu Glu Asp Asn  Leu Pro Asn 
    1040                 1045                 1050             


Thr Gln  Leu Asp Leu Leu Gly  Asn Asp Tyr Leu Val  Ser Lys Gln 
    1055                 1060                 1065             


Val Lys  Glu Tyr Arg Ile Gln  Glu Pro Asn Arg Glu  Asn Ser Phe 
    1070                 1075                 1080             


His Ser  Ser Ile Glu Ala Ile  Trp Glu Glu Cys Lys  Glu Ile Val 
    1085                 1090                 1095             


Lys Ala  Ser Ser Lys Lys Ser  His Gln Ile Glu Glu  Leu Glu Gln 
    1100                 1105                 1110             


Gln Ile  Glu Lys Leu Gln Ala  Glu Val Lys Gly Tyr  Lys Asp Glu 
    1115                 1120                 1125             


Asn Asn  Arg Leu Lys Glu Lys  Glu His Lys Asn Gln  Asp Asp Leu 
    1130                 1135                 1140             


Leu Lys  Glu Lys Glu Thr Leu  Ile Gln Gln Leu Lys  Glu Glu Leu 
    1145                 1150                 1155             


Gln Glu  Lys Asn Val Thr Leu  Asp Val Gln Ile Gln  His Val Val 
    1160                 1165                 1170             


Glu Gly  Lys Arg Ala Leu Ser  Glu Leu Thr Gln Gly  Val Thr Cys 
    1175                 1180                 1185             


Tyr Lys  Ala Lys Ile Lys Glu  Leu Glu Thr Ile Leu  Glu Thr Gln 
    1190                 1195                 1200             


Lys Val  Glu Cys Ser His Ser  Ala Lys Leu Glu Gln  Asp Ile Leu 
    1205                 1210                 1215             


Glu Lys  Glu Ser Ile Ile Leu  Lys Leu Glu Arg Asn  Leu Lys Glu 
    1220                 1225                 1230             


Phe Gln  Glu His Leu Gln Asp  Ser Val Lys Asn Thr  Lys Asp Leu 
    1235                 1240                 1245             


Asn Val  Lys Glu Leu Lys Leu  Lys Glu Glu Ile Thr  Gln Leu Thr 
    1250                 1255                 1260             


Asn Asn  Leu Gln Asp Met Lys  His Leu Leu Gln Leu  Lys Glu Glu 
    1265                 1270                 1275             


Glu Glu  Glu Thr Asn Arg Gln  Glu Thr Glu Lys Leu  Lys Glu Glu 
    1280                 1285                 1290             


Leu Ser  Ala Ser Ser Ala Arg  Thr Gln Asn Leu Lys  Ala Asp Leu 
    1295                 1300                 1305             


Gln Arg  Lys Glu Glu Asp Tyr  Ala Asp Leu Lys Glu  Lys Leu Thr 
    1310                 1315                 1320             


Asp Ala  Lys Lys Gln Ile Lys  Gln Val Gln Lys Glu  Val Ser Val 
    1325                 1330                 1335             


Met Arg  Asp Glu Asp Lys Leu  Leu Arg Ile Lys Ile  Asn Glu Leu 
    1340                 1345                 1350             


Glu Lys  Lys Lys Asn Gln Cys  Ser Gln Glu Leu Asp  Met Lys Gln 
    1355                 1360                 1365             


Arg Thr  Ile Gln Gln Leu Lys  Glu Gln Leu Asn Asn  Gln Lys Val 
    1370                 1375                 1380             


Glu Glu  Ala Ile Gln Gln Tyr  Glu Arg Ala Cys Lys  Asp Leu Asn 
    1385                 1390                 1395             


Val Lys  Glu Lys Ile Ile Glu  Asp Met Arg Met Thr  Leu Glu Glu 
    1400                 1405                 1410             


Gln Glu  Gln Thr Gln Val Glu  Gln Asp Gln Val Leu  Glu Ala Lys 
    1415                 1420                 1425             


Leu Glu  Glu Val Glu Arg Leu  Ala Thr Glu Leu Glu  Lys Trp Lys 
    1430                 1435                 1440             


Glu Lys  Cys Asn Asp Leu Glu  Thr Lys Asn Asn Gln  Arg Ser Asn 
    1445                 1450                 1455             


Lys Glu  His Glu Asn Asn Thr  Asp Val Leu Gly Lys  Leu Thr Asn 
    1460                 1465                 1470             


Leu Gln  Asp Glu Leu Gln Glu  Ser Glu Gln Lys Tyr  Asn Ala Asp 
    1475                 1480                 1485             


Arg Lys  Lys Trp Leu Glu Glu  Lys Met Met Leu Ile  Thr Gln Ala 
    1490                 1495                 1500             


Lys Glu  Ala Glu Asn Ile Arg  Asn Lys Glu Met Lys  Lys Tyr Ala 
    1505                 1510                 1515             


Glu Asp  Arg Glu Arg Phe Phe  Lys Gln Gln Asn Glu  Met Glu Ile 
    1520                 1525                 1530             


Leu Thr  Ala Gln Leu Thr Glu  Lys Asp Ser Asp Leu  Gln Lys Trp 
    1535                 1540                 1545             


Arg Glu  Glu Arg Asp Gln Leu  Val Ala Ala Leu Glu  Ile Gln Leu 
    1550                 1555                 1560             


Lys Ala  Leu Ile Ser Ser Asn  Val Gln Lys Asp Asn  Glu Ile Glu 
    1565                 1570                 1575             


Gln Leu  Lys Arg Ile Ile Ser  Glu Thr Ser Lys Ile  Glu Thr Gln 
    1580                 1585                 1590             


Ile Met  Asp Ile Lys Pro Lys  Arg Ile Ser Ser Ala  Asp Pro Asp 
    1595                 1600                 1605             


Lys Leu  Gln Thr Glu Pro Leu  Ser Thr Ser Phe Glu  Ile Ser Arg 
    1610                 1615                 1620             


Asn Lys  Ile Glu Asp Gly Ser  Val Val Leu Asp Ser  Cys Glu Val 
    1625                 1630                 1635             


Ser Thr  Glu Asn Asp Gln Ser  Thr Arg Phe Pro Lys  Pro Glu Leu 
    1640                 1645                 1650             


Glu Ile  Gln Phe Thr Pro Leu  Gln Pro Asn Lys Met  Ala Val Lys 
    1655                 1660                 1665             


His Pro  Gly Cys Thr Thr Pro  Val Thr Val Lys Ile  Pro Lys Ala 
    1670                 1675                 1680             


Arg Lys  Arg Lys Ser Asn Glu  Met Glu Glu Asp Leu  Val Lys Cys 
    1685                 1690                 1695             


Glu Asn  Lys Lys Asn Ala Thr  Pro Arg Thr Asn Leu  Lys Phe Pro 
    1700                 1705                 1710             


Ile Ser  Asp Asp Arg Asn Ser  Ser Val Lys Lys Glu  Gln Lys Val 
    1715                 1720                 1725             


Ala Ile  Arg Pro Ser Ser Lys  Lys Thr Tyr Ser Leu  Arg Ser Gln 
    1730                 1735                 1740             


Ala Ser  Ile Ile Gly Val Asn  Leu Ala Thr Lys Lys  Lys Glu Gly 
    1745                 1750                 1755             


Thr Leu  Gln Lys Phe Gly Asp  Phe Leu Gln His Ser  Pro Ser Ile 
    1760                 1765                 1770             


Leu Gln  Ser Lys Ala Lys Lys  Ile Ile Glu Thr Met  Ser Ser Ser 
    1775                 1780                 1785             


Lys Leu  Ser Asn Val Glu Ala  Ser Lys Glu Asn Val  Ser Gln Pro 
    1790                 1795                 1800             


Lys Arg  Ala Lys Arg Lys Leu  Tyr Thr Ser Glu Ile  Ser Ser Pro 
    1805                 1810                 1815             


Ile Asp  Ile Ser Gly Gln Val  Ile Leu Met Asp Gln  Lys Met Lys 
    1820                 1825                 1830             


Glu Ser  Asp His Gln Ile Ile  Lys Arg Arg Leu Arg  Thr Lys Thr 
    1835                 1840                 1845             


Ala Lys  
    1850 


<210> 7311
<211> 508
<212> PRT
<213> Homo sapiens

<400> 7311
Met Arg Cys Pro Lys Ser Ala Val Thr Met Arg Asn Glu Glu Leu Leu 
1               5                   10                  15      


Leu Ser Asn Gly Thr Ala Asn Lys Met Asn Gly Ala Leu Asp His Ser 
            20                  25                  30          


Asp Gln Pro Asp Pro Asp Ala Ile Lys Met Phe Val Gly Gln Ile Pro 
        35                  40                  45              


Arg Ser Trp Ser Glu Lys Glu Leu Lys Glu Leu Phe Glu Pro Tyr Gly 
    50                  55                  60                  


Ala Val Tyr Gln Ile Asn Val Leu Arg Asp Arg Ser Gln Asn Pro Pro 
65                  70                  75                  80  


Gln Ser Lys Gly Cys Cys Phe Val Thr Phe Tyr Thr Arg Lys Ala Ala 
                85                  90                  95      


Leu Glu Ala Gln Asn Ala Leu His Asn Ile Lys Thr Leu Pro Gly Met 
            100                 105                 110         


His His Pro Ile Gln Met Lys Pro Ala Asp Ser Glu Lys Ser Asn Ala 
        115                 120                 125             


Val Glu Asp Arg Lys Leu Phe Ile Gly Met Val Ser Lys Lys Cys Asn 
    130                 135                 140                 


Glu Asn Asp Ile Arg Val Met Phe Ser Pro Phe Gly Gln Ile Glu Glu 
145                 150                 155                 160 


Cys Arg Ile Leu Arg Gly Pro Asp Gly Leu Ser Arg Gly Cys Ala Phe 
                165                 170                 175     


Val Thr Phe Ser Thr Arg Ala Met Ala Gln Asn Ala Ile Lys Ala Met 
            180                 185                 190         


His Gln Ser Gln Thr Met Glu Gly Cys Ser Ser Pro Ile Val Val Lys 
        195                 200                 205             


Phe Ala Asp Thr Gln Lys Asp Lys Glu Gln Arg Arg Leu Gln Gln Gln 
    210                 215                 220                 


Leu Ala Gln Gln Met Gln Gln Leu Asn Thr Ala Thr Trp Gly Asn Leu 
225                 230                 235                 240 


Thr Gly Leu Gly Gly Leu Thr Pro Gln Tyr Leu Ala Leu Leu Gln Gln 
                245                 250                 255     


Ala Thr Ser Ser Ser Asn Leu Gly Ala Phe Ser Gly Ile Gln Gln Met 
            260                 265                 270         


Ala Gly Met Asn Ala Leu Gln Leu Gln Asn Leu Ala Thr Leu Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Gln Thr Ser Ala Thr Ser Thr Asn Ala Asn Pro 
    290                 295                 300                 


Leu Ser Thr Thr Ser Ser Ala Leu Gly Ala Leu Thr Ser Pro Val Ala 
305                 310                 315                 320 


Ala Ser Thr Pro Asn Ser Thr Ala Gly Ala Ala Met Asn Ser Leu Thr 
                325                 330                 335     


Ser Leu Gly Thr Leu Gln Gly Leu Ala Gly Ala Thr Val Gly Leu Asn 
            340                 345                 350         


Asn Ile Asn Ala Leu Ala Gly Met Ala Ala Leu Asn Gly Gly Leu Gly 
        355                 360                 365             


Ala Thr Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr 
    370                 375                 380                 


Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr 
385                 390                 395                 400 


Leu Tyr Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln 
                405                 410                 415     


Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln 
            420                 425                 430         


Glu Phe Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn 
        435                 440                 445             


Val Ile Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys 
    450                 455                 460                 


Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala 
465                 470                 475                 480 


Ile Gln Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val 
                485                 490                 495     


Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
            500                 505             


<210> 7312
<211> 324
<212> PRT
<213> Homo sapiens

<400> 7312
Met Phe Ile Gly Gly Leu Ser Trp Gln Thr Ser Pro Asp Ser Leu Arg 
1               5                   10                  15      


Asp Tyr Phe Ser Lys Phe Gly Glu Ile Arg Glu Cys Met Val Met Arg 
            20                  25                  30          


Asp Pro Thr Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Phe Ala 
        35                  40                  45              


Asp Pro Ala Ser Val Asp Lys Val Leu Gly Gln Pro His His Glu Leu 
    50                  55                  60                  


Asp Ser Lys Thr Ile Asp Pro Lys Val Ala Phe Pro Arg Arg Ala Gln 
65                  70                  75                  80  


Pro Lys Met Val Thr Arg Thr Lys Lys Ile Phe Val Gly Gly Leu Ser 
                85                  90                  95      


Ala Asn Thr Val Val Glu Asp Val Lys Gln Tyr Phe Glu Gln Phe Gly 
            100                 105                 110         


Lys Val Glu Asp Ala Met Leu Met Phe Asp Lys Thr Thr Asn Arg His 
        115                 120                 125             


Arg Gly Phe Gly Phe Val Thr Phe Glu Asn Glu Asp Val Val Glu Lys 
    130                 135                 140                 


Val Cys Glu Ile His Phe His Glu Ile Asn Asn Lys Met Val Glu Cys 
145                 150                 155                 160 


Lys Lys Ala Gln Pro Lys Glu Val Met Phe Pro Pro Gly Thr Arg Gly 
                165                 170                 175     


Arg Ala Arg Gly Leu Pro Tyr Thr Met Asp Ala Phe Met Leu Gly Met 
            180                 185                 190         


Gly Met Leu Gly Tyr Pro Asn Phe Val Ala Thr Tyr Gly Arg Gly Tyr 
        195                 200                 205             


Pro Gly Phe Ala Pro Ser Tyr Gly Tyr Gln Phe Pro Gly Phe Pro Ala 
    210                 215                 220                 


Ala Ala Tyr Gly Pro Val Ala Ala Ala Ala Val Ala Ala Ala Arg Gly 
225                 230                 235                 240 


Ser Val Leu Asn Ser Tyr Ser Ala Gln Pro Asn Phe Gly Ala Pro Ala 
                245                 250                 255     


Ser Pro Ala Gly Ser Asn Pro Ala Arg Pro Gly Gly Phe Pro Gly Ala 
            260                 265                 270         


Asn Ser Pro Gly Pro Val Ala Asp Leu Tyr Gly Pro Ala Ser Gln Asp 
        275                 280                 285             


Ser Gly Val Gly Asn Tyr Ile Ser Ala Ala Ser Pro Gln Pro Gly Ser 
    290                 295                 300                 


Gly Phe Gly His Gly Ile Ala Gly Pro Leu Ile Ala Thr Ala Phe Thr 
305                 310                 315                 320 


Asn Gly Tyr His 
                


<210> 7313
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7313
Xaa His Lys Pro Cys Tyr Gly Ala Leu Phe Gly Pro Arg Gly Val Asn 
1               5                   10                  15      


Ile Gly Gly Val Gly Ser Tyr Leu Tyr Asn Pro Pro Thr Pro Ser Pro 
            20                  25                  30          


Gly Cys Thr Thr Pro Leu Ser Pro Ser Ser Phe Ser Pro Pro Arg Pro 
        35                  40                  45              


Arg Thr Gly Leu Pro Gln Gly Lys Lys Thr Glu Lys Val Met Ser Leu 
    50                  55                  60                  


Gly Arg Asn Trp His Arg Pro Cys Leu Arg Cys Gln Arg Cys His Lys 
65                  70                  75                  80  


Thr Leu Thr Ala Gly Ser His Ala Glu His Asp Gly Val Pro Tyr Cys 
                85                  90                  95      


His Val Pro Cys Tyr Gly Tyr Leu Phe Gly Pro Lys Ala Leu 
            100                 105                 110 


<210> 7314
<211> 136
<212> PRT
<213> Homo sapiens

<400> 7314
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala 
    130                 135     


<210> 7315
<211> 561
<212> PRT
<213> Homo sapiens

<400> 7315
Met Ala Ser Gln Phe Cys Leu Pro Glu Ser Pro Cys Leu Ser Pro Pro 
1               5                   10                  15      


Pro Leu Ser Pro Leu Ala Leu Ala Pro Ser Ser Ala Ile Arg Asp Gln 
            20                  25                  30          


Arg Thr Ala Thr Lys Trp Val Ala Met Ile Pro Gln Lys Asn Gln Thr 
        35                  40                  45              


Ala Ser Gly Asp Ser Leu Asp Val Arg Val Pro Ser Lys Pro Cys Leu 
    50                  55                  60                  


Met Lys Gln Lys Lys Ser Pro Cys Leu Trp Glu Ile Gln Lys Leu Gln 
65                  70                  75                  80  


Glu Gln Arg Glu Lys Arg Arg Arg Leu Gln Gln Glu Ile Arg Ala Arg 
                85                  90                  95      


Arg Ala Leu Asp Val Asn Thr Arg Asn Pro Asn Tyr Glu Ile Met His 
            100                 105                 110         


Met Ile Glu Glu Tyr Arg Arg His Leu Asp Ser Ser Lys Ile Ser Val 
        115                 120                 125             


Leu Glu Pro Pro Gln Glu His Arg Ile Cys Val Cys Val Arg Lys Arg 
    130                 135                 140                 


Pro Leu Asn Gln Arg Glu Thr Thr Leu Lys Asp His Ala Phe Asp Asp 
145                 150                 155                 160 


Lys Ala Ser Asn Glu Leu Val Tyr Gln Phe Thr Ala Gln Pro Leu Val 
                165                 170                 175     


Glu Ser Ile Phe Arg Lys Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln 
            180                 185                 190         


Thr Gly Ser Gly Lys Thr Tyr Thr Met Gly Gly Asp Phe Ser Gly Thr 
        195                 200                 205             


Ala Gln Asp Cys Ser Lys Gly Ile Tyr Ala Leu Val Ala Gln Asp Val 
    210                 215                 220                 


Phe Leu Leu Leu Arg Asn Ser Thr Tyr Glu Lys Leu Asp Leu Lys Val 
225                 230                 235                 240 


Tyr Gly Thr Phe Phe Glu Ile Tyr Gly Gly Lys Val Tyr Asp Leu Leu 
                245                 250                 255     


Asn Trp Lys Lys Lys Leu Gln Val Leu Glu Asp Gly Asn Gln Gln Ile 
            260                 265                 270         


Gln Val Val Gly Leu Gln Glu Lys Glu Val Cys Cys Val Glu Glu Val 
        275                 280                 285             


Leu Asn Leu Val Glu Ile Gly Asn Ser Cys Arg Thr Ser Arg Gln Thr 
    290                 295                 300                 


Pro Val Asn Ala His Ser Ser Arg Ser His Ala Val Phe Gln Ile Ile 
305                 310                 315                 320 


Leu Lys Ser Gly Arg Ile Met His Gly Lys Phe Ser Leu Val Asp Leu 
                325                 330                 335     


Ala Gly Asn Glu Arg Gly Ala Asp Thr Thr Lys Ala Ser Arg Lys Arg 
            340                 345                 350         


Gln Leu Glu Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu 
        355                 360                 365             


Cys Ile Leu Ala Leu Gly Gln Asn Lys Pro His Thr Pro Phe Arg Ala 
    370                 375                 380                 


Ser Lys Leu Thr Leu Val Leu Arg Asp Ser Phe Ile Gly Gln Asn Ser 
385                 390                 395                 400 


Ser Thr Cys Met Ile Ala Thr Ile Ser Pro Gly Met Thr Ser Cys Glu 
                405                 410                 415     


Asn Thr Leu Asn Thr Leu Arg Tyr Ala Asn Arg Val Lys Lys Leu Asn 
            420                 425                 430         


Val Asp Val Arg Pro Tyr His Arg Gly His Tyr Pro Ile Gly His Glu 
        435                 440                 445             


Ala Pro Arg Met Leu Lys Ser His Ile Gly Asn Ser Glu Met Ser Leu 
    450                 455                 460                 


Gln Arg Asp Glu Phe Ile Lys Ile Pro Tyr Val Gln Ser Glu Glu Gln 
465                 470                 475                 480 


Lys Glu Ile Glu Glu Val Glu Thr Leu Pro Thr Leu Leu Gly Lys Asp 
                485                 490                 495     


Thr Thr Ile Ser Gly Lys Gly Ser Ser Gln Trp Leu Glu Asn Ile Gln 
            500                 505                 510         


Glu Arg Ala Gly Gly Val His His Asp Ile Asp Phe Cys Ile Ala Arg 
        515                 520                 525             


Ser Leu Ser Ile Leu Glu Gln Lys Ile Asp Ala Leu Thr Glu Ile Gln 
    530                 535                 540                 


Lys Lys Leu Lys Leu Leu Leu Ala Asp Leu His Val Lys Ser Lys Val 
545                 550                 555                 560 


Glu 
    


<210> 7316
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7316
Xaa Ser Ala Cys Ile Gly Asn Cys Ser Thr Ala Leu Glu Glu Leu Thr 
1               5                   10                  15      


Asp Asp Met Thr Glu Asp Phe Leu Pro Val Leu Arg Glu Tyr Ile Leu 
            20                  25                  30          


Tyr Ser Asp Ser Met Lys Ser Val Leu Lys Lys Arg Asp Gln Val Gln 
        35                  40                  45              


Ala Glu Tyr Glu Ala Lys Leu Glu Ala Val Ala Leu Arg Lys Glu Asp 
    50                  55                  60                  


Arg Pro Lys Val Pro Ala Asp Val Glu Lys Cys Gln Asp Arg Met Glu 
65                  70                  75                  80  


Cys Phe Asn Ala Asp Leu Lys Ala Asp Met Glu Arg Trp Gln Asn Asn 
                85                  90                  95      


Lys Arg Gln Asp Phe Arg Gln Leu Leu Met Gly Met Ala Asp Lys Asn 
            100                 105                 110         


Ile Gln Tyr Tyr Glu Lys Ser Ile Ala Asp Leu Lys 
        115                 120                 


<210> 7317
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7317
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 7318
<211> 374
<212> PRT
<213> Homo sapiens

<400> 7318
Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Leu Trp Asn Asp Glu 
            180                 185                 190         


Val Asp Lys Ala Glu Gln Glu Leu Arg Val Ala Gln Thr Glu Phe Asp 
        195                 200                 205             


Arg Gln Ala Glu Val Thr Arg Leu Leu Leu Glu Gly Ile Ser Ser Thr 
    210                 215                 220                 


His Val Asn His Leu Arg Cys Leu His Glu Phe Val Lys Ser Gln Thr 
225                 230                 235                 240 


Thr Tyr Tyr Ala Gln Cys Tyr Arg His Met Leu Asp Leu Gln Lys Gln 
                245                 250                 255     


Leu Gly Arg Phe Pro Gly Thr Phe Val Gly Thr Thr Glu Pro Ala Ser 
            260                 265                 270         


Pro Pro Leu Ser Ser Thr Ser Pro Thr Thr Ala Ala Ala Thr Met Pro 
        275                 280                 285             


Val Val Pro Ser Val Ala Ser Leu Ala Pro Pro Gly Glu Ala Ser Leu 
    290                 295                 300                 


Cys Leu Glu Glu Val Ala Pro Pro Ala Ser Gly Thr Arg Lys Ala Arg 
305                 310                 315                 320 


Val Leu Tyr Asp Tyr Glu Ala Ala Asp Ser Ser Glu Leu Ala Leu Leu 
                325                 330                 335     


Ala Asp Glu Leu Ile Thr Val Tyr Ser Leu Pro Gly Met Asp Pro Asp 
            340                 345                 350         


Trp Leu Ile Gly Glu Arg Gly Asn Lys Lys Gly Lys Val Pro Val Thr 
        355                 360                 365             


Tyr Leu Glu Leu Leu Ser 
    370                 


<210> 7319
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7319
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210> 7320
<211> 376
<212> PRT
<213> Homo sapiens

<400> 7320
Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
1               5                   10                  15      


Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
            20                  25                  30          


Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
        35                  40                  45              


Asp Tyr Ala Gly Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser 
    50                  55                  60                  


Thr Gln Ala His Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn 
65                  70                  75                  80  


Gly Ser Leu Thr Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser 
                85                  90                  95      


Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg 
            100                 105                 110         


Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg 
        115                 120                 125             


Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile Phe 
    130                 135                 140                 


Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn Ser 
145                 150                 155                 160 


Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val Glu 
                165                 170                 175     


Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr Asn 
            180                 185                 190         


Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro Val 
        195                 200                 205             


Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe Gln 
    210                 215                 220                 


Ala Asp Val Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly Arg 
225                 230                 235                 240 


Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro Tyr 
                245                 250                 255     


Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu Arg 
            260                 265                 270         


Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro Thr 
        275                 280                 285             


Ala Ile Pro Ala Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr Gly 
    290                 295                 300                 


Ala Asp Leu Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln Pro Ala 
305                 310                 315                 320 


Thr Ala Thr Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Tyr Ser 
                325                 330                 335     


Asp Gly Tyr Gly Arg Val Tyr Thr Ala Asp Pro Tyr His Ala Leu Ala 
            340                 345                 350         


Pro Ala Ala Ser Tyr Gly Val Gly Ala Val Ala Ser Leu Tyr Arg Gly 
        355                 360                 365             


Gly Tyr Ser Arg Phe Ala Pro Tyr 
    370                 375     


<210> 7321
<211> 545
<212> PRT
<213> Homo sapiens

<400> 7321
Met Gly Thr Pro Trp Arg Pro Pro Ser Arg Arg Pro Trp Arg Trp Pro 
1               5                   10                  15      


Thr Gly Cys Thr Arg Lys Thr Cys Gly Pro Pro Thr Trp Ser Leu Glu 
            20                  25                  30          


Arg Thr Arg Ser Trp Leu Ser Gly Arg Glu His Ser Val Phe Thr Gly 
        35                  40                  45              


Val Ala Ile Val His Cys Ser Ser Lys Asp His Gln Leu Asp Thr Arg 
    50                  55                  60                  


Val Ser Glu Phe Tyr Glu Glu Thr Lys Val Lys Phe Ser Glu Leu Ser 
65                  70                  75                  80  


Glu Glu Leu Leu Trp Glu Tyr Val His Ser Gly Glu Pro Met Asp Lys 
                85                  90                  95      


Ala Gly Gly Tyr Gly Ile Gln Ala Leu Gly Gly Met Leu Val Glu Ser 
            100                 105                 110         


Val His Gly Asp Phe Leu Asn Val Val Gly Phe Pro Leu Asn His Phe 
        115                 120                 125             


Cys Lys Gln Leu Val Lys Leu Tyr Tyr Pro Pro Arg Pro Glu Asp Leu 
    130                 135                 140                 


Arg Arg Ser Val Lys His Asp Ser Ile Pro Ala Ala Asp Thr Phe Glu 
145                 150                 155                 160 


Asp Leu Ser Asp Val Glu Gly Gly Gly Ser Glu Pro Thr Gln Arg Asp 
                165                 170                 175     


Ala Gly Ser Arg Asp Glu Lys Ala Glu Ala Gly Glu Ala Gly Gln Ala 
            180                 185                 190         


Thr Ala Glu Ala Glu Cys His Arg Thr Arg Glu Thr Leu Pro Pro Phe 
        195                 200                 205             


Pro Thr Arg Leu Leu Glu Leu Ile Glu Gly Phe Met Leu Ser Lys Gly 
    210                 215                 220                 


Leu Leu Thr Ala Cys Lys Leu Lys Val Phe Asp Leu Leu Lys Asp Glu 
225                 230                 235                 240 


Ala Pro Gln Lys Ala Ala Asp Ile Ala Ser Lys Val Asp Ala Ser Ala 
                245                 250                 255     


Cys Gly Met Glu Arg Leu Leu Asp Ile Cys Ala Ala Met Gly Leu Leu 
            260                 265                 270         


Glu Lys Thr Glu Gln Gly Tyr Ser Asn Thr Glu Thr Ala Asn Val Tyr 
        275                 280                 285             


Leu Ala Ser Asp Gly Glu Tyr Ser Leu His Gly Phe Ile Met His Asn 
    290                 295                 300                 


Asn Asp Leu Thr Trp Asn Leu Phe Thr Tyr Leu Glu Phe Ala Ile Arg 
305                 310                 315                 320 


Glu Gly Thr Asn Gln His His Arg Ala Leu Gly Lys Lys Ala Glu Asp 
                325                 330                 335     


Leu Phe Gln Asp Ala Tyr Tyr Gln Ser Pro Glu Thr Arg Leu Arg Phe 
            340                 345                 350         


Met Arg Ala Met His Gly Met Thr Lys Leu Thr Ala Cys Gln Val Ala 
        355                 360                 365             


Thr Ala Phe Asn Leu Ser Arg Phe Ser Ser Ala Cys Asp Val Gly Gly 
    370                 375                 380                 


Cys Thr Gly Ala Leu Ala Arg Glu Leu Ala Arg Glu Tyr Pro Arg Met 
385                 390                 395                 400 


Gln Val Thr Val Phe Asp Leu Pro Asp Ile Ile Glu Leu Ala Ala His 
                405                 410                 415     


Phe Gln Pro Pro Gly Pro Gln Ala Val Gln Ile His Phe Ala Ala Gly 
            420                 425                 430         


Asp Phe Phe Arg Asp Pro Leu Pro Ser Ala Glu Leu Tyr Val Leu Cys 
        435                 440                 445             


Arg Ile Leu His Asp Trp Pro Asp Asp Lys Val His Lys Leu Leu Ser 
    450                 455                 460                 


Arg Val Ala Glu Ser Cys Lys Pro Gly Ala Gly Leu Leu Leu Val Glu 
465                 470                 475                 480 


Thr Leu Leu Asp Glu Glu Lys Arg Val Ala Gln Arg Ala Leu Met Gln 
                485                 490                 495     


Ser Leu Asn Met Leu Val Gln Thr Glu Gly Lys Glu Arg Ser Leu Gly 
            500                 505                 510         


Glu Tyr Gln Cys Leu Leu Glu Leu His Gly Phe His Gln Val Gln Val 
        515                 520                 525             


Val His Leu Gly Gly Val Leu Asp Ala Ile Leu Ala Thr Lys Val Ala 
    530                 535                 540                 


Pro 
545 


<210> 7322
<211> 206
<212> PRT
<213> Homo sapiens

<400> 7322
Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Met Arg Arg Ala Val Asn Pro Asn 
        35                  40                  45              


His Ser Leu Arg Cys Cys Pro Phe Gln Gly His Ser Ser Cys Arg Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ala Glu Gly Thr Ala Leu Gly Pro Cys His Thr Ile 
65                  70                  75                  80  


Arg Ile Tyr Ile His Met Cys Leu Leu Trp Glu Gln Gly Gln Gln Ile 
                85                  90                  95      


Thr Met Met Arg Val Ser Arg Asp His Thr Thr Asp Ser Gly Gly Glu 
            100                 105                 110         


Pro Gln Thr Thr Trp Gly Ser Gln Glu Ser Ser Leu Arg Lys Thr Asp 
        115                 120                 125             


Ser Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile Ser Arg Ser 
    130                 135                 140                 


Pro Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser Arg Asn Thr 
145                 150                 155                 160 


Ser Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr Pro Ser Thr 
                165                 170                 175     


Ser Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser Gly Gln Pro 
            180                 185                 190         


Ser Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu 
        195                 200                 205     


<210> 7323
<211> 137
<212> PRT
<213> Homo sapiens

<400> 7323
Met Ala Pro Gly Thr Pro Lys Ser Leu Leu Leu Ser Ala Ser Ile Lys 
1               5                   10                  15      


Arg Glu Gly Glu Ser Pro Thr Ala Ser Pro His Ser Ser Ala Thr Asp 
            20                  25                  30          


Asp Leu His His Ser Asp Arg Tyr Gln Thr Phe Leu Arg Val Arg Ala 
        35                  40                  45              


Asn Arg Gln Thr Arg Leu Asn Ala Arg Ile Gly Lys Met Lys Arg Arg 
    50                  55                  60                  


Lys Gln Asp Glu Gly Gln Val Cys Pro Leu Cys Asn Arg Pro Leu Ala 
65                  70                  75                  80  


Gly Ser Glu Gln Glu Met Ser Arg His Val Glu His Cys Leu Ser Lys 
                85                  90                  95      


Arg Glu Gly Ser Cys Met Ala Glu Asp Asp Ala Val Asp Ile Glu His 
            100                 105                 110         


Glu Asn Asn Asn Arg Phe Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg 
        115                 120                 125             


Ile Arg Ala Thr Thr Leu Leu Glu Gly 
    130                 135         


<210> 7324
<211> 189
<212> PRT
<213> Homo sapiens

<400> 7324
Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg 
1               5                   10                  15      


Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr 
            20                  25                  30          


His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln 
        35                  40                  45              


Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr 
    50                  55                  60                  


Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr 
65                  70                  75                  80  


Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala 
                85                  90                  95      


Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala 
            100                 105                 110         


His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser 
    130                 135                 140                 


Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr 
145                 150                 155                 160 


Tyr Gln Gln Pro Ala Ala Thr Glu Ala Gly Ser Ser Ser Ser Cys Cys 
                165                 170                 175     


Cys Cys Cys Asn Ser Cys Leu Asp Arg Asp His Leu Tyr 
            180                 185                 


<210> 7325
<211> 128
<212> PRT
<213> Homo sapiens

<400> 7325
Met Asp Ala Asp Ser Asp Val Ala Leu Asp Ile Leu Ile Thr Asn Val 
1               5                   10                  15      


Val Cys Val Phe Arg Thr Arg Cys His Leu Asn Leu Arg Lys Ile Ala 
            20                  25                  30          


Leu Glu Gly Ala Asn Val Ile Tyr Lys Arg Asp Val Gly Lys Val Leu 
        35                  40                  45              


Met Lys Leu Arg Lys Pro Arg Ile Thr Ala Thr Ile Trp Ser Ser Gly 
    50                  55                  60                  


Lys Ile Ile Cys Thr Gly Ala Thr Ser Glu Glu Glu Ala Lys Phe Gly 
65                  70                  75                  80  


Ala Arg Arg Leu Ala Arg Ser Leu Gln Lys Leu Gly Phe Gln Val Ile 
                85                  90                  95      


Phe Thr Asp Phe Lys Val Val Asn Val Leu Ala Val Cys Asn Met Pro 
            100                 105                 110         


Phe Glu Ile Arg Leu Pro Glu Phe Thr Lys Asn Asn Arg Pro His Ala 
        115                 120                 125             


<210> 7326
<211> 126
<212> PRT
<213> Homo sapiens

<400> 7326
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr 
        115                 120                 125     


<210> 7327
<211> 303
<212> PRT
<213> Homo sapiens

<400> 7327
Glu Asp Glu Tyr Ile Gln Ser His Asn Phe Asp Ser Ala Met Lys Val 
1               5                   10                  15      


Thr Ser Gln Gly Gln Pro Ser Pro Val Glu Pro Arg Gly Pro Phe Tyr 
            20                  25                  30          


Phe Cys Arg Leu Leu Leu Asp Asp Leu Gly Met Asn Ser Trp Asp Arg 
        35                  40                  45              


Arg Lys Asn Phe His Leu Leu Lys Lys Asn Ser Lys Leu Leu Arg Glu 
    50                  55                  60                  


Leu Lys Asn Leu Asp Ser Arg Gln Cys Arg Glu Thr His Lys Ile Ala 
65                  70                  75                  80  


Val Phe Tyr Ile Ala Glu Gly Gln Glu Asp Lys Cys Ser Ile Leu Ser 
                85                  90                  95      


Asn Glu Arg Gly Ser Gln Ala Tyr Glu Asp Phe Val Ala Gly Leu Gly 
            100                 105                 110         


Trp Glu Val Asp Leu Ser Thr His Cys Gly Phe Met Gly Gly Leu Gln 
        115                 120                 125             


Arg Asn Gly Ser Thr Gly Gln Thr Ala Pro Tyr Tyr Ala Thr Ser Thr 
    130                 135                 140                 


Val Glu Val Ile Phe His Val Ser Thr Arg Met Pro Ser Asp Ser Asp 
145                 150                 155                 160 


Asp Ser Leu Thr Lys Lys Leu Arg His Leu Gly Asn Asp Glu Val His 
                165                 170                 175     


Ile Val Trp Ser Glu His Ser Arg Asp Tyr Arg Arg Gly Ile Ile Pro 
            180                 185                 190         


Thr Ala Phe Gly Asp Val Ser Ile Ile Ile Tyr Pro Met Lys Asn His 
        195                 200                 205             


Met Phe Phe Ile Ala Ile Thr Lys Lys Pro Glu Val Pro Phe Phe Gly 
    210                 215                 220                 


Pro Leu Phe Asp Gly Ala Ile Val Ser Gly Lys Leu Leu Pro Ser Leu 
225                 230                 235                 240 


Val Cys Ala Thr Cys Ile Asn Ala Ser Arg Ala Val Lys Cys Leu Ile 
                245                 250                 255     


Pro Leu Tyr Gln Ser Phe Tyr Glu Glu Arg Ala Leu Tyr Leu Glu Ala 
            260                 265                 270         


Ile Ile Gln Asn His Arg Glu Val Met Thr Phe Glu Asp Phe Ala Ala 
        275                 280                 285             


Gln Val Phe Ser Pro Ser Pro Ser Tyr Ser Leu Ser Gly Thr Asp 
    290                 295                 300             


<210> 7328
<211> 960
<212> PRT
<213> Homo sapiens

<400> 7328
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Thr Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Thr Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Thr Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Thr Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Thr Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Thr Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Thr Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Thr Thr Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys 
        435                 440                 445             


Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro 
            500                 505                 510         


Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser 
        515                 520                 525             


Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Thr 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Thr Ser Ser Pro Val Thr 
        675                 680                 685             


Cys Ser Ser Asn Ala Cys Leu Val Thr Thr Asp Gln Ala Ser Ser Gly 
    690                 695                 700                 


Ser Glu Thr Glu Phe Met Thr Ser Glu Thr Pro Glu Ala Ala Ile Pro 
705                 710                 715                 720 


Pro Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala 
                725                 730                 735     


Lys Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser 
            740                 745                 750         


Val Thr Ile Asn Thr Ala Pro Phe Gln Ala Met Gln Thr Val Phe Asn 
        755                 760                 765             


Val Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser 
    770                 775                 780                 


Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln 
785                 790                 795                 800 


Thr Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Thr Val 
                805                 810                 815     


His Ser Gln Glu Thr Ala Asn Tyr His Pro Asp Gly Thr Ile Gln Val 
            820                 825                 830         


Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Thr Asn Val Phe Pro 
        835                 840                 845             


Arg Pro Thr Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg Gly Cys 
    850                 855                 860                 


Thr Arg Gly Gly Arg Leu Ile Thr Asn Ser Tyr Arg Ser Pro Gly Gly 
865                 870                 875                 880 


Tyr Lys Gly Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile Ser Asn Gly 
                885                 890                 895     


Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala Pro 
            900                 905                 910         


Tyr Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg Gly Gly Thr 
        915                 920                 925             


Ser Gly Gly Pro Arg Ala Asn Ser Arg Ala Asn Cys Phe Ile Met Arg 
    930                 935                 940                 


Asn Ser Leu Leu Leu Ile Lys Gln Gln Gly Gly Val Ile Leu Leu Arg 
945                 950                 955                 960 


<210> 7329
<211> 581
<212> PRT
<213> Homo sapiens

<400> 7329
Asn Asn Asn Gly Thr Tyr Asp Gly Ile Ala Tyr Phe Glu Cys Lys Glu 
1               5                   10                  15      


Lys His Gly Ile Phe Ala Pro Pro Gln Lys Ile Ser His Ile Pro Glu 
            20                  25                  30          


Asn Phe Asp Asp Tyr Val Asp Ile Asn Glu Asp Glu Asp Cys Tyr Ser 
        35                  40                  45              


Asp Glu Arg Tyr Gln Cys Tyr Asn Gln Glu Gln Asn Asp Thr Glu Gly 
    50                  55                  60                  


Pro Lys Asp Arg Glu Lys Asp Val Ser Glu Tyr Phe Tyr Glu Lys Ser 
65                  70                  75                  80  


Leu Pro Ser Val Asn Asp Ile Glu Ala Ser Val Asn Arg Ser Arg Ser 
                85                  90                  95      


Leu Lys Ile Glu Thr Asp Asn Val Gln Asp Ile Ser Gly Val Leu Glu 
            100                 105                 110         


Ala His Val His Gln Gln Ser Ser Val Asp Ser Gln Ile Ser Ser Lys 
        115                 120                 125             


Glu Asn Lys Asp Leu Ile Ser Asp Ala Thr Glu Lys Val Ser Ile Ala 
    130                 135                 140                 


Ala Glu Asp Asp Thr Leu Asp Asn Thr Phe Ser Glu Glu Leu Glu Lys 
145                 150                 155                 160 


Gln Gln Gln Phe Thr Glu Glu Glu Asp Asn Leu Tyr Ala Glu Ala Ser 
                165                 170                 175     


Glu Lys Leu Cys Thr Pro Leu Leu Asp Leu Leu Thr Arg Glu Lys Asn 
            180                 185                 190         


Gln Leu Glu Ala Gln Leu Lys Ser Ser Leu Asn Glu Glu Lys Lys Ser 
        195                 200                 205             


Lys Gln Gln Leu Glu Lys Ile Ser Leu Leu Thr Asp Ser Leu Leu Lys 
    210                 215                 220                 


Val Phe Val Lys Asp Thr Val Asn Gln Leu Gln Gln Ile Lys Lys Thr 
225                 230                 235                 240 


Arg Asp Glu Lys Ile Gln Leu Ser Asn Gln Glu Leu Leu Gly Asp Asp 
                245                 250                 255     


Gln Lys Lys Val Thr Pro Gln Asp Leu Ser Gln Asn Val Glu Glu Gln 
            260                 265                 270         


Ser Pro Ser Ile Ser Gly Cys Phe Leu Ser Ser Glu Leu Glu Asp Glu 
        275                 280                 285             


Lys Glu Glu Ile Ser Ser Pro Asp Met Cys Pro Arg Pro Glu Ser Pro 
    290                 295                 300                 


Val Phe Gly Ala Ser Gly Gln Glu Glu Leu Ala Lys Arg Leu Ala Glu 
305                 310                 315                 320 


Leu Glu Leu Ser Arg Glu Phe Leu Ser Ala Leu Gly Asp Asp Gln Asp 
                325                 330                 335     


Trp Phe Asp Glu Asp Phe Gly Leu Ser Ser Ser His Lys Ile Gln Lys 
            340                 345                 350         


Asn Lys Ala Glu Glu Thr Ile Val Pro Leu Met Ala Glu Pro Lys Arg 
        355                 360                 365             


Val Thr Gln Gln Pro Cys Glu Thr Leu Leu Ala Val Pro His Thr Ala 
    370                 375                 380                 


Glu Glu Val Glu Ile Leu Val His Asn Ala Ala Glu Glu Leu Trp Lys 
385                 390                 395                 400 


Trp Lys Glu Leu Gly His Asp Leu His Ser Ile Ser Ile Pro Thr Lys 
                405                 410                 415     


Leu Leu Gly Cys Ala Ser Lys Gly Leu Asp Ile Glu Ser Thr Ser Lys 
            420                 425                 430         


Arg Val Tyr Lys Gln Ala Val Phe Asp Leu Thr Lys Glu Ile Phe Glu 
        435                 440                 445             


Glu Ile Phe Ala Glu Asp Pro Asn Leu Asn Gln Pro Val Trp Met Lys 
    450                 455                 460                 


Pro Cys Arg Ile Asn Ser Ser Tyr Phe Arg Arg Val Lys Asn Pro Asn 
465                 470                 475                 480 


Asn Leu Asp Glu Ile Lys Ser Phe Ile Ala Ser Glu Val Leu Lys Leu 
                485                 490                 495     


Phe Ser Leu Lys Lys Glu Pro Asn His Lys Thr Asp Trp Gln Lys Met 
            500                 505                 510         


Met Lys Phe Gly Arg Lys Lys Arg Asp Arg Val Asp His Ile Leu Val 
        515                 520                 525             


Gln Glu Leu His Glu Glu Glu Ala Gln Trp Val Asn Tyr Asp Glu Asp 
    530                 535                 540                 


Glu Leu Cys Val Lys Met Gln Leu Ala Asp Gly Ile Phe Glu Thr Leu 
545                 550                 555                 560 


Ile Lys Asp Thr Ile Asp Val Leu Asn Gln Ile Ser Glu Lys Gln Gly 
                565                 570                 575     


Arg Met Leu Leu Val 
            580     


<210> 7330
<211> 114
<212> PRT
<213> Homo sapiens

<400> 7330
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys 
        


<210> 7331
<211> 305
<212> PRT
<213> Homo sapiens

<400> 7331
Met Glu Ala Glu Ser Phe Pro Cys Leu Leu Arg Pro Phe Phe Lys Glu 
1               5                   10                  15      


Arg Ser Cys Ala Leu Arg Pro Ala Phe His Thr Ala Lys Cys Glu Lys 
            20                  25                  30          


Leu Gln Lys Glu Lys Glu Glu Leu Glu Arg Arg Phe Glu Ala Glu Met 
        35                  40                  45              


Ala Arg Leu Gln Glu Glu His Gly Asp Gln Leu Leu Ser Ile Arg Cys 
    50                  55                  60                  


Gln His Gln Glu Gln Val Glu Asp Leu Thr Ala Ser His Asp Ala Ala 
65                  70                  75                  80  


Leu Leu Glu Met Glu Asn Asn His Thr Val Ala Ile Thr Ile Leu Gln 
                85                  90                  95      


Asp Asp His Asp His Lys Val Gln Glu Leu Met Ser Thr His Glu Leu 
            100                 105                 110         


Glu Lys Lys Glu Leu Glu Glu Asn Phe Glu Lys Leu Arg Leu Ser Leu 
        115                 120                 125             


Gln Asp Gln Val Asp Thr Leu Thr Phe Gln Ser Gln Ser Leu Arg Asp 
    130                 135                 140                 


Arg Ala Arg Arg Phe Glu Glu Ala Leu Arg Lys Asn Thr Glu Glu Gln 
145                 150                 155                 160 


Leu Glu Ile Ala Leu Ala Pro Tyr Gln His Leu Glu Glu Asp Met Lys 
                165                 170                 175     


Ser Leu Lys Gln Val Leu Glu Met Lys Asn Gln Gln Ile His Glu Gln 
            180                 185                 190         


Glu Lys Lys Ile Leu Glu Leu Glu Lys Leu Ala Glu Lys Asn Ile Ile 
        195                 200                 205             


Leu Glu Glu Lys Ile Gln Val Leu Gln Gln Gln Asn Glu Asp Leu Lys 
    210                 215                 220                 


Ala Arg Ile Asp Gln Asn Thr Val Val Thr Arg Gln Leu Ser Glu Glu 
225                 230                 235                 240 


Asn Ala Asn Leu Gln Glu Tyr Val Glu Lys Glu Thr Gln Glu Lys Lys 
                245                 250                 255     


Arg Leu Ser Arg Thr Asn Glu Glu Leu Leu Trp Lys Leu Gln Thr Gly 
            260                 265                 270         


Asp Pro Thr Ser Pro Ile Lys Leu Ser Pro Thr Ser Pro Val Tyr Arg 
        275                 280                 285             


Gly Ser Ser Ser Gly Pro Ser Ser Pro Ala Arg Val Ser Thr Thr Pro 
    290                 295                 300                 


Arg 
305 


<210> 7332
<211> 772
<212> PRT
<213> Homo sapiens

<400> 7332
Met Gln Glu Leu Glu Glu Leu Arg Lys Gln Leu Gly Ser Val Ala Thr 
1               5                   10                  15      


Gly Ser Thr Leu Gln Gln Ser Leu Glu Leu Lys Arg Lys Met Leu Arg 
            20                  25                  30          


Asp Lys Gln Asn Lys Lys Asn Ser Gly Gln His Leu Pro Ile Phe Pro 
        35                  40                  45              


Ala Trp Val Tyr Glu Arg Pro Ala Leu Ile Gly Asp Phe Leu Ile Gly 
    50                  55                  60                  


Ala Gly Ile Ser Thr Asp Thr Ala Leu Pro Ile Gly Thr Leu Pro Leu 
65                  70                  75                  80  


Ala Ser Gln Glu Ser Ala Val Val Glu Asp Leu Leu Tyr Val Leu Val 
                85                  90                  95      


Gly Val Asp Gly Arg Tyr Val Ser Ala Gln Pro Leu Ala Gly Arg Gln 
            100                 105                 110         


Ser Arg Thr Phe Leu Val Asp Pro Asn Leu Asp Leu Ser Ile Arg Glu 
        115                 120                 125             


Leu Val His Arg Ile Leu Pro Val Ala Ala Ser Tyr Ser Ala Val Thr 
    130                 135                 140                 


Arg Phe Ile Glu Glu Lys Ser Ser Phe Glu Tyr Gly Gln Val Asn His 
145                 150                 155                 160 


Ala Leu Ala Ala Ala Met Arg Thr Leu Val Lys Glu His Leu Ile Leu 
                165                 170                 175     


Val Ser Gln Leu Glu Gln Leu His Arg Gln Gly Leu Leu Ser Leu Gln 
            180                 185                 190         


Lys Leu Trp Phe Tyr Ile Gln Pro Ala Met Arg Thr Met Asp Ile Leu 
        195                 200                 205             


Ala Ser Leu Ala Thr Ser Val Asp Lys Gly Glu Cys Leu Gly Gly Ser 
    210                 215                 220                 


Thr Leu Ser Leu Leu His Asp Arg Ser Phe Ser Tyr Thr Gly Asp Ser 
225                 230                 235                 240 


Gln Ala Gln Glu Leu Cys Leu Tyr Leu Thr Lys Ala Ala Ser Ala Pro 
                245                 250                 255     


Tyr Phe Glu Val Leu Glu Lys Trp Ile Tyr Arg Gly Ile Ile His Asp 
            260                 265                 270         


Pro Tyr Ser Glu Phe Met Val Glu Glu His Glu Leu Arg Lys Glu Arg 
        275                 280                 285             


Ile Gln Glu Asp Tyr Asn Asp Lys Tyr Trp Asp Gln Arg Tyr Thr Ile 
    290                 295                 300                 


Val Gln Gln Gln Ile Pro Ser Phe Leu Gln Lys Met Ala Asp Lys Ile 
305                 310                 315                 320 


Leu Ser Thr Gly Lys Tyr Leu Asn Val Val Arg Glu Cys Gly His Asp 
                325                 330                 335     


Val Thr Cys Pro Val Ala Lys Glu Ile Ile Tyr Thr Leu Lys Glu Arg 
            340                 345                 350         


Ala Tyr Val Glu Gln Ile Glu Lys Ala Phe Asn Tyr Ala Ser Lys Val 
        355                 360                 365             


Leu Leu Asp Phe Leu Met Glu Glu Lys Glu Leu Val Ala His Leu Arg 
    370                 375                 380                 


Ser Ile Lys Arg Tyr Phe Leu Met Asp Gln Gly Asp Phe Phe Val His 
385                 390                 395                 400 


Phe Met Asp Leu Ala Glu Glu Glu Leu Arg Lys Pro Val Glu Asp Ile 
                405                 410                 415     


Thr Pro Pro Arg Leu Glu Ala Leu Leu Glu Leu Ala Leu Arg Met Ser 
            420                 425                 430         


Thr Ala Asn Thr Asp Pro Phe Lys Asp Asp Leu Lys Ile Asp Leu Met 
        435                 440                 445             


Pro His Asp Leu Ile Thr Gln Leu Leu Arg Val Leu Ala Ile Glu Thr 
    450                 455                 460                 


Lys Gln Glu Lys Ala Met Ala His Ala Asp Pro Thr Glu Leu Ala Leu 
465                 470                 475                 480 


Ser Gly Leu Glu Ala Phe Ser Phe Asp Tyr Ile Val Lys Trp Pro Leu 
                485                 490                 495     


Ser Leu Ile Ile Asn Arg Lys Ala Leu Thr Arg Tyr Gln Met Leu Phe 
            500                 505                 510         


Arg His Met Phe Tyr Cys Lys His Val Glu Arg Gln Leu Cys Ser Val 
        515                 520                 525             


Trp Ile Ser Asn Lys Thr Ala Lys Gln His Ser Leu His Ser Ala Gln 
    530                 535                 540                 


Trp Phe Ala Gly Ala Phe Thr Leu Arg Gln Arg Met Leu Asn Phe Val 
545                 550                 555                 560 


Gln Asn Ile Gln Tyr Tyr Met Met Phe Glu Val Met Glu Pro Thr Trp 
                565                 570                 575     


His Ile Leu Glu Lys Asn Leu Lys Ser Ala Ser Asn Ile Asp Asp Val 
            580                 585                 590         


Leu Gly His His Thr Gly Phe Leu Asp Thr Cys Leu Lys Asp Cys Met 
        595                 600                 605             


Leu Thr Asn Pro Glu Leu Leu Lys Val Phe Ser Lys Leu Met Ser Val 
    610                 615                 620                 


Cys Val Met Phe Thr Asn Cys Met Gln Lys Phe Thr Gln Ser Met Lys 
625                 630                 635                 640 


Leu Asp Gly Glu Leu Gly Gly Gln Thr Leu Glu His Ser Thr Val Leu 
                645                 650                 655     


Gly Leu Pro Ala Gly Ala Glu Glu Arg Ala Arg Lys Glu Leu Ala Arg 
            660                 665                 670         


Lys His Leu Ala Glu His Ala Asp Thr Val Gln Leu Val Ser Gly Phe 
        675                 680                 685             


Glu Ala Thr Ile Asn Lys Phe Asp Lys Asn Phe Ser Ala His Leu Leu 
    690                 695                 700                 


Asp Leu Leu Ala Arg Leu Ser Ile Tyr Ser Thr Ser Asp Cys Glu His 
705                 710                 715                 720 


Gly Met Ala Ser Val Ile Ser Arg Leu Asp Phe Asn Gly Phe Tyr Thr 
                725                 730                 735     


Glu Arg Leu Glu Arg Leu Ser Ala Glu Arg Ser Gln Lys Ala Thr Pro 
            740                 745                 750         


Gln Val Pro Val Leu Arg Gly Pro Pro Ala Pro Ala Pro Arg Val Ala 
        755                 760                 765             


Val Thr Ala Gln 
    770         


<210> 7333
<211> 400
<212> PRT
<213> Homo sapiens

<400> 7333
Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Thr Val Pro Asp Phe 
            180                 185                 190         


Gln Glu Thr Arg Pro Arg Asn Tyr Ile Leu Ser Ala Ser Ala Ser Ala 
        195                 200                 205             


Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gln Glu Leu Arg Val Ala 
    210                 215                 220                 


Gln Thr Glu Phe Asp Arg Gln Ala Glu Val Thr Arg Leu Leu Leu Glu 
225                 230                 235                 240 


Gly Ile Ser Ser Thr His Val Asn His Leu Arg Cys Leu His Glu Phe 
                245                 250                 255     


Val Lys Ser Gln Thr Thr Tyr Tyr Ala Gln Cys Tyr Arg His Met Leu 
            260                 265                 270         


Asp Leu Gln Lys Gln Leu Gly Ser Ser Gln Gly Ala Ile Phe Pro Gly 
        275                 280                 285             


Thr Phe Val Gly Thr Thr Glu Pro Ala Ser Pro Pro Leu Ser Ser Thr 
    290                 295                 300                 


Ser Pro Thr Thr Ala Ala Ala Thr Met Pro Val Val Pro Ser Val Ala 
305                 310                 315                 320 


Ser Leu Ala Pro Pro Gly Glu Ala Ser Leu Cys Leu Glu Glu Val Ala 
                325                 330                 335     


Pro Pro Ala Ser Gly Thr Arg Lys Ala Arg Val Leu Tyr Asp Tyr Glu 
            340                 345                 350         


Ala Ala Asp Ser Ser Glu Leu Ala Leu Leu Ala Asp Glu Leu Ile Thr 
        355                 360                 365             


Val Tyr Ser Leu Pro Gly Met Asp Pro Asp Trp Leu Ile Gly Glu Arg 
    370                 375                 380                 


Gly Asn Lys Lys Gly Lys Val Pro Val Thr Tyr Leu Glu Leu Leu Ser 
385                 390                 395                 400 


<210> 7334
<211> 608
<212> PRT
<213> Homo sapiens

<400> 7334
Met Pro Phe Trp Pro Ile Arg Cys Leu Lys Arg Ser Arg Arg Met Pro 
1               5                   10                  15      


Arg Gly Gly Ala Gly Glu Arg Glu Lys Val Pro Ala Asn Pro Glu Ala 
            20                  25                  30          


Leu Leu Leu Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln 
        35                  40                  45              


Ala Ile Arg Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly 
    50                  55                  60                  


Gln Arg Leu Glu Glu Thr Val His His Glu Arg Lys Tyr Gly Pro Arg 
65                  70                  75                  80  


Leu Ala Pro Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg 
                85                  90                  95      


Gly Leu Thr Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu 
            100                 105                 110         


Val Arg Asp Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe 
        115                 120                 125             


Asp Ser Thr Thr Asp Val His Thr Val Ala Ser Leu Leu Lys Leu Tyr 
    130                 135                 140                 


Leu Arg Glu Leu Pro Glu Pro Val Val Pro Phe Ala Arg Tyr Glu Asp 
145                 150                 155                 160 


Phe Leu Ser Cys Ala Gln Leu Leu Thr Lys Asp Glu Gly Glu Gly Thr 
                165                 170                 175     


Leu Glu Leu Ala Lys Gln Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn 
            180                 185                 190         


Leu Leu Arg Tyr Ile Cys Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser 
        195                 200                 205             


Asn Val Asn Lys Met Ser Val Gln Asn Leu Ala Thr Val Phe Gly Pro 
    210                 215                 220                 


Asn Ile Leu Arg Pro Gln Val Glu Asp Pro Val Thr Ile Met Glu Gly 
225                 230                 235                 240 


Thr Ser Leu Val Gln His Leu Met Thr Val Leu Ile Arg Lys His Ser 
                245                 250                 255     


Gln Leu Phe Thr Ala Pro Val Pro Glu Gly Pro Thr Ser Pro Arg Gly 
            260                 265                 270         


Gly Leu Gln Cys Ala Val Gly Trp Gly Ser Glu Glu Val Thr Arg Asp 
        275                 280                 285             


Ser Gln Gly Glu Pro Gly Gly Pro Gly Leu Pro Ala His Arg Thr Ser 
    290                 295                 300                 


Ser Leu Asp Gly Ala Ala Val Ala Val Leu Ser Arg Thr Ala Pro Thr 
305                 310                 315                 320 


Gly Pro Gly Ser Arg Cys Ser Pro Gly Lys Lys Val Gln Thr Leu Pro 
                325                 330                 335     


Ser Trp Lys Ser Ser Phe Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro 
            340                 345                 350         


Lys Gly Gly Gly Ser Ser Leu Glu Val Pro Ile Ile Ser Ser Gly Gly 
        355                 360                 365             


Asn Trp Leu Met Asn Gly Leu Ser Ser Leu Arg Gly His Arg Arg Ala 
    370                 375                 380                 


Ser Ser Gly Asp Arg Leu Lys Asp Ser Gly Ser Val Gln Arg Leu Ser 
385                 390                 395                 400 


Thr Tyr Asp Asn Val Pro Ala Pro Gly Leu Val Pro Gly Ile Pro Ser 
                405                 410                 415     


Val Ala Ser Met Ala Trp Ser Gly Ala Ser Ser Ser Glu Ser Ser Val 
            420                 425                 430         


Gly Gly Ser Leu Ser Ser Cys Thr Ala Cys Arg Ala Ser Asp Ser Ser 
        435                 440                 445             


Ala Arg Ser Ser Leu His Thr Asp Trp Ala Leu Glu Pro Ser Pro Leu 
    450                 455                 460                 


Pro Ser Ser Ser Glu Asp Pro Lys Ser Leu Asp Leu Asp His Ser Met 
465                 470                 475                 480 


Asp Glu Ala Gly Ala Gly Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp 
                485                 490                 495     


Ser Pro Thr Arg Glu His Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu 
            500                 505                 510         


Val Thr Glu Leu Arg Ala Glu Leu Cys Arg Gln Arg Thr Glu Tyr Glu 
        515                 520                 525             


Arg Ser Val Lys Arg Ile Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg 
    530                 535                 540                 


Met Ser Arg Leu Glu Glu Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile 
545                 550                 555                 560 


Met Leu Glu Ile Lys Leu Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala 
                565                 570                 575     


Glu Arg Arg Asn Gln Leu Leu Gln Arg Glu Met Glu Glu Phe Phe Ser 
            580                 585                 590         


Thr Leu Gly Ser Leu Thr Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
        595                 600                 605             


<210> 7335
<211> 235
<212> PRT
<213> Homo sapiens

<400> 7335
Met Phe Ser Glu Glu Cys Ile Met Asp Val Ile Gly Cys Leu Glu Tyr 
1               5                   10                  15      


Asp Pro Ala Leu Ser Gln Pro Arg Lys His Arg Glu Phe Leu Thr Lys 
            20                  25                  30          


Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Ser Asp Pro Glu Leu Lys 
        35                  40                  45              


Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile Gln Asp Met Val 
    50                  55                  60                  


Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Met Leu Ser Thr Leu His 
65                  70                  75                  80  


Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Gly Met Leu Gln Glu 
                85                  90                  95      


Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr Asp Glu Ala 
            100                 105                 110         


Thr Asp Glu Glu Lys Arg Gln Glu Leu Val Asn Phe Leu Lys Glu Phe 
        115                 120                 125             


Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg Asp Ala Phe Phe 
    130                 135                 140                 


Lys Thr Leu Ser Asn Met Gly Ile Leu Pro Ala Leu Glu Val Ile Leu 
145                 150                 155                 160 


Gly Met Asp Asp Thr Gln Val Arg Ser Ala Ala Thr Asp Ile Phe Ser 
                165                 170                 175     


Tyr Leu Val Glu Tyr Asn Pro Ser Met Val Arg Glu Phe Val Met Gln 
            180                 185                 190         


Glu Ala Gln Gln Asn Asp Asp Val Ser Lys Lys Leu Thr Glu Gln Lys 
        195                 200                 205             


Ile Thr Ser Lys Val Asn Ile Ile Cys Thr Asn Ser Lys Tyr Leu Tyr 
    210                 215                 220                 


Ile Gly Ser Tyr Asn Cys Phe Tyr Tyr Ser Phe 
225                 230                 235 


<210> 7336
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 7336
Val Tyr Lys Gly Arg His Val Lys Thr Gly Gln Leu Ala Ala Ile Lys 
1               5                   10                  15      


Val Met Asp Val Thr Glu Asp Glu Glu Glu Glu Ile Lys Leu Glu Ile 
            20                  25                  30          


Asn Met Leu Lys Lys Tyr Ser His His Arg Asn Ile Ala Thr Tyr Tyr 
        35                  40                  45              


Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly His Asp Asp Gln Leu Trp 
    50                  55                  60                  


Leu Val Met Glu Phe Cys Gly Ala Gly Ser Ile Thr Asp Leu Val Lys 
65                  70                  75                  80  


Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp Trp Ile Ala Tyr Ile Ser 
                85                  90                  95      


Arg Glu Ile Leu Arg Gly Leu Ala His Leu His Ile His His Val Ile 
            100                 105                 110         


His Arg Asp Ile Lys Gly Gln Asn Val Leu Leu Thr Glu Asn Ala Glu 
        115                 120                 125             


Val Lys Leu Val Asp Phe Gly Val Ser Ala Gln Leu Asp Arg Thr Val 
    130                 135                 140                 


Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro Tyr Trp Met Ala Pro Glu 
145                 150                 155                 160 


Val Ile Ala Cys Asp Glu Asn Pro Asp Ala Thr Tyr Asp Tyr Arg Ser 
                165                 170                 175     


Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile Glu Met Ala Glu Gly Ala 
            180                 185                 190         


Pro Pro Leu Cys Asp Met His Pro Met Arg Ala Leu Phe Leu Ile Pro 
        195                 200                 205             


Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys Lys Trp Ser Lys Lys Phe 
    210                 215                 220                 


Phe Ser Phe Ile Glu Gly Cys Leu Val Lys Asn Tyr Met Gln Arg Pro 
225                 230                 235                 240 


Ser Thr Glu Gln Leu Leu Lys His Pro Phe Ile Arg Asp Gln Pro Asn 
                245                 250                 255     


Glu Arg Gln Val Arg Ile Gln Leu Lys Asp His Ile Asp Arg Thr Arg 
            260                 265                 270         


Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu Tyr Glu Tyr Ser Gly Ser 
        275                 280                 285             


Glu Glu Glu Glu Glu Glu Val Pro Glu Gln Glu Gly Glu Pro Ser Ser 
    290                 295                 300                 


Ile Val Asn Val Pro Gly Glu Ser Thr Leu Arg Arg Asp Phe Leu Arg 
305                 310                 315                 320 


Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu Ala Leu Arg Arg Gln Gln 
                325                 330                 335     


Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln Glu Glu Tyr Lys Arg Gln 
            340                 345                 350         


Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Gln Gln Lys Glu Gln Arg 
        355                 360                 365             


Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Arg Glu Ala Arg Arg Gln 
    370                 375                 380                 


Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln Glu Glu Lys Arg Arg Leu 
385                 390                 395                 400 


Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Arg Ala 
                405                 410                 415     


Glu Glu Glu Lys Arg Arg Val Glu Arg Glu Gln Glu Tyr Ile Arg Arg 
            420                 425                 430         


Gln Leu Glu Glu Glu Gln Arg His Leu Glu Val Leu Gln Gln Gln Leu 
        435                 440                 445             


Leu Gln Glu Gln Ala Met Leu Leu His Asp His Arg Arg Pro His Pro 
    450                 455                 460                 


Gln His Ser Gln Gln Pro Pro Pro Pro Gln Gln Glu Arg Ser Lys Pro 
465                 470                 475                 480 


Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr Glu Pro Ala Asp Arg 
                485                 490                 495     


Ala Arg Glu Val Glu Asp Arg Phe Arg Lys Thr Asn His Ser Ser Pro 
            500                 505                 510         


Glu Ala Gln Ser Lys Gln Thr Gly Arg Val Leu Glu Pro Pro Val Pro 
        515                 520                 525             


Ser Arg Ser Glu Ser Phe Ser Asn Gly Asn Ser Glu Ser Val His Pro 
    530                 535                 540                 


Ala Leu Gln Arg Pro Ala Glu Pro Gln Val Pro Val Arg Thr Thr Ser 
545                 550                 555                 560 


Arg Ser Pro Val Leu Ser Arg Arg Asp Ser Pro Leu Gln Gly Ser Gly 
                565                 570                 575     


Gln Gln Asn Ser Gln Ala Gly Gln Arg Asn Ser Thr Ser Ile Glu Pro 
            580                 585                 590         


Arg Leu Leu Trp Glu Arg Val Glu Lys Leu Val Pro Arg Pro Gly Ser 
        595                 600                 605             


Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly Ser Gln Pro Gly Ser His 
    610                 615                 620                 


Pro Gly Ser Gln Ser Gly Ser Gly Glu Arg Phe Arg Val Arg Ser Ser 
625                 630                 635                 640 


Ser Lys Ser Glu Gly Ser Pro Ser Gln Arg Leu Glu Asn Ala Val Lys 
                645                 650                 655     


Lys Pro Glu Asp Lys Lys Glu Val Phe Arg Pro Leu Lys Pro Ala Asp 
            660                 665                 670         


Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val Glu Asp Val Arg Pro 
        675                 680                 685             


Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser Gly Thr 
    690                 695                 700                 


Thr Asp Glu Glu Asp Asp Asp Val Glu Gln Glu Gly Ala Asp Glu Ser 
705                 710                 715                 720 


Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser Ser Leu Asn Leu Ser 
                725                 730                 735     


Asn Gly Glu Thr Glu Ser Val Lys Thr Met Ile Val His Asp Asp Val 
            740                 745                 750         


Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu Gly Thr Leu Ile Val 
        755                 760                 765             


Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu Gln Lys His Lys Ser Ser 
    770                 775                 780                 


Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg Leu Leu Gln Ile Ser Pro 
785                 790                 795                 800 


Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly Phe Ser Cys Asp Gly 
                805                 810                 815     


Met Arg Pro Glu Ala Ile Arg Gln Asp Pro Thr Arg Lys Gly Ser Val 
            820                 825                 830         


Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gln Ser Asp Thr Pro Glu 
        835                 840                 845             


Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu Ile Leu Cys Ala Ala 
    850                 855                 860                 


Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu Ser Gly Leu Met Leu 
865                 870                 875                 880 


Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Pro Leu Ile Asn Arg Arg 
                885                 890                 895     


Arg Phe Gln Gln Met Asp Val Leu Glu Gly Leu Asn Val Leu Val Thr 
            900                 905                 910         


Ile Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr Tyr Leu Ser Trp Leu 
        915                 920                 925             


Arg Asn Lys Ile Leu His Asn Asp Pro Glu Val Glu Lys Lys Gln Gly 
    930                 935                 940                 


Trp Thr Thr Val Gly Asp Leu Glu Gly Cys Val His Tyr Lys Val Val 
945                 950                 955                 960 


Lys Tyr Glu Arg Ile Lys Phe Leu Val Ile Ala Leu Lys Ser Ser Val 
                965                 970                 975     


Glu Val Tyr Ala Trp Ala Pro Lys Pro Tyr His Lys Phe Met Ala Phe 
            980                 985                 990         


Lys Ser Phe Gly Glu Leu Val His  Lys Pro Leu Leu Val  Asp Leu Thr 
        995                 1000                 1005             


Val Glu  Glu Gly Gln Arg Leu  Lys Val Ile Tyr Gly  Ser Cys Ala 
    1010                 1015                 1020             


Gly Phe  His Ala Val Asp Val  Asp Ser Gly Ser Val  Tyr Asp Ile 
    1025                 1030                 1035             


Tyr Leu  Pro Thr His Ile Gln  Cys Ser Ile Lys Pro  His Ala Ile 
    1040                 1045                 1050             


Ile Ile  Leu Pro Asn Thr Asp  Gly Met Glu Leu Leu  Val Cys Tyr 
    1055                 1060                 1065             


Glu Asp  Glu Gly Val Tyr Val  Asn Thr Tyr Gly Arg  Ile Thr Lys 
    1070                 1075                 1080             


Asp Val  Val Leu Gln Trp Gly  Glu Met Pro Thr Ser  Val Ala Tyr 
    1085                 1090                 1095             


Ile Arg  Ser Asn Gln Thr Met  Gly Trp Gly Glu Lys  Ala Ile Glu 
    1100                 1105                 1110             


Ile Arg  Ser Val Glu Thr Gly  His Leu Asp Gly Val  Phe Met His 
    1115                 1120                 1125             


Lys Arg  Ala Gln Arg Leu Lys  Phe Leu Cys Glu Arg  Asn Asp Lys 
    1130                 1135                 1140             


Val Phe  Phe Ala Ser Val Arg  Ser Gly Gly Ser Ser  Gln Val Tyr 
    1145                 1150                 1155             


Phe Met  Thr Leu Gly Arg Thr  Ser Leu Leu Ser Trp  
    1160                 1165                 1170 


<210> 7337
<211> 491
<212> PRT
<213> Homo sapiens

<400> 7337
Val Ile Ile His Arg Val Leu Glu Lys Gln Glu Val Glu Val Phe Tyr 
1               5                   10                  15      


Pro Asp Phe Gly Asn Ile Gly Ile Val Gln Lys Ser Ser Leu Arg Phe 
            20                  25                  30          


Leu Lys Cys Cys Tyr Thr Lys Leu Pro Ala Gln Ala Ile Pro Cys Ser 
        35                  40                  45              


Leu Ala Trp Val Arg Pro Val Glu Glu His Trp Thr Ser Lys Ala Ile 
    50                  55                  60                  


Leu Gln Phe Gln Lys Leu Cys Gly Leu Lys Pro Leu Val Gly Val Val 
65                  70                  75                  80  


Asp Glu Tyr Val Asp Gly Ile Leu Asn Ile Phe Leu Cys Asp Thr Ser 
                85                  90                  95      


Ser Asn Glu Asp Val Tyr Phe His His Val Leu Arg Thr Glu Gly His 
            100                 105                 110         


Ala Ile Val Cys Arg Glu Asn Ile Ser Ser Lys Gly Phe Ser Glu Leu 
        115                 120                 125             


Asn Pro Leu Ala Leu Tyr Thr Thr Ser Ser Gly Gly Pro Glu Asp Ile 
    130                 135                 140                 


Val Leu Thr Glu Leu Gly Tyr Pro Ser Gln Gln His Tyr Phe Asn Glu 
145                 150                 155                 160 


Asp Arg Lys Ile Ser Pro Gln Ser Lys Glu Ser Glu Leu Arg Ile Leu 
                165                 170                 175     


Gln Asp Ile Asn Asp Glu Lys Ser Leu Ser His Leu Lys Ser Glu Ser 
            180                 185                 190         


Lys Glu Pro Leu Lys Asp Ser Glu Phe Glu Ser Leu Lys Thr Cys Asn 
        195                 200                 205             


Lys Ser Phe Glu Glu Asp Pro Lys Trp Ser Asn Pro Glu Pro Asn Asp 
    210                 215                 220                 


Leu Lys Glu Glu Asn Glu Asp Glu Ile Pro Thr Gly Met Pro Cys Leu 
225                 230                 235                 240 


Glu Ser Val Thr Ile Gly Asp Asp Ile Trp Asp Glu Asn Trp Leu Pro 
                245                 250                 255     


Leu Gln Ala Lys Met Gly Lys Gly Gly Asp Ala Ala Ser His Leu Phe 
            260                 265                 270         


Thr Ala Ser Leu Gly Gly Lys Asn Gln Tyr Ser Ser Cys Lys Glu Met 
        275                 280                 285             


Pro Gln Lys Asp Trp Cys Phe Ser Thr Pro Lys Asp Thr Trp Asp Asp 
    290                 295                 300                 


Ser Trp Gln Pro Ser Gly Leu Val Asn Gly Thr Lys Val Glu Val His 
305                 310                 315                 320 


Lys Pro Glu Val Leu Gly Ala Gln Glu Lys Asn Thr Gly Thr Asn Arg 
                325                 330                 335     


Thr Gln Lys Gln Leu Asp Ile Asn Gly Ser Ser Asp Ser Ser Thr Leu 
            340                 345                 350         


Pro Lys Leu Glu Glu Phe Cys Thr Ser Leu Thr Gln Ser Glu Gln Ser 
        355                 360                 365             


Ala Asp Gly Ser Gln Ser Glu Pro Asn Asn Ser Gln Thr Gln Pro Lys 
    370                 375                 380                 


Gln Ile Gln Leu Ser Thr Ala Ala Pro Cys Ser Thr Thr Ala Val Asp 
385                 390                 395                 400 


Asp Ser Ala Glu Lys Pro Ser Gly Ser Val Glu Ser Ser Pro Glu Ile 
                405                 410                 415     


Leu Lys Asn Glu Asp Phe Ser Ser Ser Arg Ala Ile Thr Leu Tyr Lys 
            420                 425                 430         


Asp Lys Arg Gln Glu Ser Val Asp Gln Leu Ser Leu Ile Leu Ser Tyr 
        435                 440                 445             


Glu Cys Gln Ile Ser Gln Lys Leu Tyr Ile Pro Arg Ser Thr Ala Thr 
    450                 455                 460                 


Ala Ala Leu Gly Ala Ala Ala Arg Leu Ala Thr Ser Arg Ser Leu Leu 
465                 470                 475                 480 


His Trp Tyr Pro Ser Val Lys Arg Met Glu Ala 
                485                 490     


<210> 7338
<211> 141
<212> PRT
<213> Homo sapiens

<400> 7338
Met Pro Thr Thr Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Thr Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser 
    50                  55                  60                  


Ser Gly Ser Pro Ile Gly Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro 
65                  70                  75                  80  


Pro Ser Phe Asn Leu His Pro Ala Pro His Leu Leu Ala Ser Met His 
                85                  90                  95      


Leu Gln Lys Leu Asn Ser Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro 
            100                 105                 110         


Gly Gln Pro Gly Glu Ala Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala 
        115                 120                 125             


Gln Ala Gly Gly Ala Glu Ser Leu Ser Pro Ser Ala Gly 
    130                 135                 140     


<210> 7339
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7339
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210> 7340
<211> 447
<212> PRT
<213> Homo sapiens

<400> 7340
Met Ala Thr Asp Ser Trp Ala Leu Ala Val Asp Glu Gln Glu Ala Ala 
1               5                   10                  15      


Val Lys Ser Met Thr Asn Leu Gln Ile Lys Glu Glu Lys Val Lys Ala 
            20                  25                  30          


Asp Thr Asn Gly Ile Ile Lys Thr Ser Thr Thr Ala Glu Lys Thr Asp 
        35                  40                  45              


Glu Glu Glu Lys Glu Asp Arg Ala Ala Gln Ser Leu Leu Asn Lys Leu 
    50                  55                  60                  


Ile Arg Ser Asn Leu Val Asp Asn Thr Asn Gln Val Glu Val Leu Gln 
65                  70                  75                  80  


Arg Asp Pro Asn Ser Pro Leu Tyr Ser Val Lys Ser Phe Glu Glu Leu 
                85                  90                  95      


Arg Leu Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly Thr Gly Lys 
            100                 105                 110         


Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Glu Pro Ser Asp 
        115                 120                 125             


Arg Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr Tyr Glu Leu Ala Leu 
    130                 135                 140                 


Gln Thr Gly Lys Val Ile Glu Gln Met Gly Lys Phe Tyr Pro Glu Leu 
145                 150                 155                 160 


Lys Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu Glu Arg Gly Gln Lys 
                165                 170                 175     


Ile Ser Glu Gln Ile Val Ile Gly Thr Pro Gly Thr Val Leu Asp Trp 
            180                 185                 190         


Cys Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys Ile Lys Val Phe Val 
        195                 200                 205             


Leu Asp Glu Ala Asp Val Met Ile Ala Thr Gln Gly His Gln Asp Gln 
    210                 215                 220                 


Ser Ile Arg Ile Gln Arg Met Leu Pro Arg Asn Cys Gln Met Leu Leu 
225                 230                 235                 240 


Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Lys Phe Ala Gln Lys Val 
                245                 250                 255     


Val Pro Asp Pro Asn Val Ile Lys Leu Lys Arg Glu Glu Glu Thr Leu 
            260                 265                 270         


Asp Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser Ser Arg Asp Glu Lys 
        275                 280                 285             


Phe Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile Thr Ile Ala Gln Ala 
    290                 295                 300                 


Met Ile Phe Cys His Thr Arg Lys Thr Ala Ser Trp Leu Ala Ala Glu 
305                 310                 315                 320 


Leu Ser Lys Glu Gly His Gln Val Ala Leu Leu Ser Gly Glu Met Met 
                325                 330                 335     


Val Glu Gln Arg Ala Ala Val Ile Glu Arg Phe Arg Glu Gly Lys Glu 
            340                 345                 350         


Lys Val Leu Val Thr Thr Asn Val Cys Ala Arg Gly Ile Asp Val Glu 
        355                 360                 365             


Gln Val Ser Val Val Ile Asn Phe Asp Leu Pro Val Asp Lys Asp Gly 
    370                 375                 380                 


Asn Pro Asp Asn Glu Thr Tyr Leu His Arg Ile Gly Arg Thr Gly Arg 
385                 390                 395                 400 


Phe Gly Lys Arg Gly Leu Ala Val Asn Met Val Asp Ser Lys His Ser 
                405                 410                 415     


Met Asn Ile Leu Asn Arg Ile Gln Glu His Phe Asn Lys Lys Ile Glu 
            420                 425                 430         


Arg Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu Lys Ile Ala Asn 
        435                 440                 445         


<210> 7341
<211> 209
<212> PRT
<213> Homo sapiens

<400> 7341
Met Ala Ser Ser Asp Leu Glu Gln Leu Cys Ser His Val Asn Glu Lys 
1               5                   10                  15      


Ile Gly Asn Ile Lys Lys Thr Leu Ser Leu Arg Asn Cys Gly Gln Glu 
            20                  25                  30          


Pro Thr Leu Lys Thr Val Leu Asn Lys Ile Gly Asp Glu Ile Ile Val 
        35                  40                  45              


Ile Asn Glu Leu Leu Asn Lys Leu Glu Leu Glu Ile Gln Tyr Gln Glu 
    50                  55                  60                  


Gln Thr Asn Asn Ser Leu Lys Glu Leu Cys Glu Ser Leu Glu Glu Asp 
65                  70                  75                  80  


Tyr Lys Asp Ile Glu His Leu Lys Glu Asn Val Pro Ser His Leu Pro 
                85                  90                  95      


Gln Val Thr Val Thr Gln Ser Trp Tyr Met Lys Ser Arg Leu Thr Tyr 
            100                 105                 110         


Asn Gln Ile Asn Asp Val Ile Lys Glu Ile Asn Lys Ala Val Ile Ser 
        115                 120                 125             


Lys Tyr Lys Ile Leu His Gln Pro Lys Lys Ser Met Asn Ser Val Thr 
    130                 135                 140                 


Arg Asn Leu Tyr His Arg Phe Ile Asp Glu Glu Thr Lys Asp Thr Lys 
145                 150                 155                 160 


Gly Arg Tyr Phe Ile Val Glu Ala Asp Ile Lys Glu Phe Thr Thr Leu 
                165                 170                 175     


Lys Ala Asp Lys Lys Phe His Val Leu Leu Asn Ile Leu Arg His Cys 
            180                 185                 190         


Arg Arg Leu Ser Glu Val Arg Gly Gly Gly Leu Thr Arg Tyr Val Ile 
        195                 200                 205             


Thr 
    


<210> 7342
<211> 374
<212> PRT
<213> Homo sapiens

<400> 7342
Met Asp Ser Val Arg Ser Gly Pro Phe Gly Gln Leu Phe Arg Pro Asp 
1               5                   10                  15      


Asn Phe Ile Phe Gly Gln Thr Gly Ala Gly Asn Asn Trp Ala Lys Gly 
            20                  25                  30          


His Tyr Thr Glu Gly Ala Glu Leu Val Asp Ala Val Leu Asp Val Val 
        35                  40                  45              


Arg Lys Glu Cys Glu His Cys Asp Cys Leu Gln Gly Phe Gln Leu Thr 
    50                  55                  60                  


His Ser Leu Gly Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Ile 
65                  70                  75                  80  


Ser Lys Ile Arg Glu Glu Phe Pro Asp Arg Ile Met Asn Thr Phe Ser 
                85                  90                  95      


Val Met Pro Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn 
            100                 105                 110         


Ala Thr Leu Ser Val His Gln Leu Val Glu Asn Thr Asp Glu Thr Tyr 
        115                 120                 125             


Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys 
    130                 135                 140                 


Leu Thr Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr 
145                 150                 155                 160 


Met Ser Gly Val Thr Thr Ser Leu Arg Phe Pro Gly Gln Leu Asn Ala 
                165                 170                 175     


Asp Leu Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His 
            180                 185                 190         


Phe Phe Met Pro Gly Phe Ala Pro Leu Thr Ser Arg Gly Ser Gln Gln 
        195                 200                 205             


Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr Gln Gln Met Phe Asp Ala 
    210                 215                 220                 


Arg Asn Met Met Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr 
225                 230                 235                 240 


Val Ala Thr Val Phe Arg Gly Pro Met Ser Met Lys Glu Val Asp Glu 
                245                 250                 255     


Gln Met Leu Ala Ile Gln Ser Lys Asn Ser Ser Tyr Phe Val Glu Trp 
            260                 265                 270         


Ile Pro Asn Asn Val Lys Val Ala Val Cys Asp Ile Pro Pro Arg Gly 
        275                 280                 285             


Leu Lys Met Ala Ser Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu 
    290                 295                 300                 


Leu Phe Lys Arg Ile Ser Glu Gln Phe Ser Ala Met Phe Arg Arg Lys 
305                 310                 315                 320 


Ala Phe Leu His Trp Phe Thr Gly Glu Gly Met Asp Glu Met Glu Phe 
                325                 330                 335     


Thr Glu Ala Glu Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln 
            340                 345                 350         


Tyr Gln Asp Ala Thr Ala Asn Asp Gly Glu Glu Ala Phe Glu Asp Glu 
        355                 360                 365             


Glu Glu Glu Ile Asp Gly 
    370                 


<210> 7343
<211> 762
<212> PRT
<213> Homo sapiens

<400> 7343
Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr Asp Gln Asp Leu Leu 
1               5                   10                  15      


Leu Met Gln Glu Gly Met Pro Met Arg Lys Val Arg Ser Lys Ser Trp 
            20                  25                  30          


Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp Gly Met Thr Val Trp 
        35                  40                  45              


His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro Ser Phe Ser Ile Ser 
    50                  55                  60                  


Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser Glu Leu Leu Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe Thr Ile Val Phe His 
                85                  90                  95      


Gly Arg Arg Ser Asn Leu Asp Leu Met Ala Asn Ser Val Glu Glu Ala 
            100                 105                 110         


Gln Ile Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser 
        115                 120                 125             


Met Asp His Gln Glu Arg Leu Asp Gln Trp Leu Ser Asp Trp Phe Gln 
    130                 135                 140                 


Arg Gly Asp Lys Asn Gln Asp Gly Lys Met Ser Phe Gln Glu Val Gln 
145                 150                 155                 160 


Arg Leu Leu His Leu Met Asn Val Glu Met Asp Gln Glu Tyr Ala Phe 
                165                 170                 175     


Ser Leu Phe Gln Ala Ala Asp Thr Ser Gln Ser Gly Thr Leu Glu Gly 
            180                 185                 190         


Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Ala Glu Val 
        195                 200                 205             


Gln Glu Leu Phe Glu Ser Phe Ser Ala Asp Gly Gln Lys Leu Thr Leu 
    210                 215                 220                 


Leu Glu Phe Leu Asp Phe Leu Gln Glu Glu Gln Lys Glu Arg Asp Cys 
225                 230                 235                 240 


Thr Ser Glu Leu Ala Leu Glu Leu Ile Asp Arg Tyr Glu Pro Ser Asp 
                245                 250                 255     


Ser Gly Lys Leu Arg His Val Leu Ser Met Asp Gly Phe Leu Ser Tyr 
            260                 265                 270         


Leu Cys Ser Lys Asp Gly Asp Ile Phe Asn Pro Ala Cys Leu Pro Ile 
        275                 280                 285             


Tyr Gln Asp Met Thr Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser 
    290                 295                 300                 


His Asn Thr Tyr Leu Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val 
305                 310                 315                 320 


Glu Gly Tyr Ile Arg Ala Leu Lys Arg Gly Cys Arg Cys Val Glu Val 
                325                 330                 335     


Asp Val Trp Asp Gly Pro Ser Gly Glu Pro Val Val Tyr His Gly His 
            340                 345                 350         


Thr Leu Thr Ser Arg Ile Leu Phe Lys Asp Val Val Ala Thr Val Ala 
        355                 360                 365             


Gln Tyr Ala Phe Gln Thr Ser Asp Tyr Pro Val Ile Leu Ser Leu Glu 
    370                 375                 380                 


Thr His Cys Ser Trp Glu Gln Gln Gln Thr Met Ala Arg His Leu Thr 
385                 390                 395                 400 


Glu Ile Leu Gly Glu Gln Leu Leu Ser Thr Thr Leu Asp Gly Val Leu 
                405                 410                 415     


Pro Thr Gln Leu Pro Ser Pro Glu Glu Leu Arg Arg Lys Ile Leu Val 
            420                 425                 430         


Lys Gly Lys Lys Leu Thr Leu Glu Glu Asp Leu Glu Tyr Glu Glu Glu 
        435                 440                 445             


Glu Ala Glu Pro Glu Leu Glu Glu Ser Glu Leu Ala Leu Glu Ser Gln 
    450                 455                 460                 


Phe Glu Thr Glu Pro Glu Pro Gln Glu Gln Asn Leu Gln Asn Lys Asp 
465                 470                 475                 480 


Lys Lys Lys Lys Ser Lys Pro Ile Leu Cys Pro Ala Leu Ser Ser Leu 
                485                 490                 495     


Val Ile Tyr Leu Lys Ser Val Ser Phe Arg Ser Phe Thr His Ser Lys 
            500                 505                 510         


Glu His Tyr His Phe Tyr Glu Ile Ser Ser Phe Ser Glu Thr Lys Ala 
        515                 520                 525             


Lys Arg Leu Ile Lys Glu Ala Gly Asn Glu Phe Val Gln His Asn Thr 
    530                 535                 540                 


Trp Gln Leu Ser Arg Val Tyr Pro Ser Gly Leu Arg Thr Asp Ser Ser 
545                 550                 555                 560 


Asn Tyr Asn Pro Gln Glu Leu Trp Asn Ala Gly Cys Gln Met Val Ala 
                565                 570                 575     


Met Asn Met Gln Thr Ala Gly Leu Glu Met Asp Ile Cys Asp Gly His 
            580                 585                 590         


Phe Arg Gln Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro Asp Phe Leu 
        595                 600                 605             


Arg Asp Ile Gln Ser Ser Phe His Pro Glu Lys Pro Ile Ser Pro Phe 
    610                 615                 620                 


Lys Ala Gln Thr Leu Leu Ile Gln Val Ile Ser Gly Gln Gln Leu Pro 
625                 630                 635                 640 


Lys Val Asp Lys Thr Lys Glu Gly Ser Ile Val Asp Pro Leu Val Lys 
                645                 650                 655     


Val Gln Ile Phe Gly Val Arg Leu Asp Thr Ala Arg Gln Glu Thr Asn 
            660                 665                 670         


Tyr Val Glu Asn Asn Gly Phe Asn Pro Tyr Trp Gly Gln Thr Leu Cys 
        675                 680                 685             


Phe Arg Val Leu Val Pro Glu Leu Ala Met Leu Arg Phe Val Val Met 
    690                 695                 700                 


Asp Tyr Asp Trp Lys Ser Arg Asn Asp Phe Ile Gly Gln Tyr Thr Leu 
705                 710                 715                 720 


Pro Trp Thr Cys Met Gln Gln Gly Tyr Arg His Ile His Leu Leu Ser 
                725                 730                 735     


Lys Asp Gly Ile Ser Leu Arg Pro Ala Ser Ile Phe Val Tyr Ile Cys 
            740                 745                 750         


Ile Gln Glu Gly Leu Glu Gly Asp Glu Ser 
        755                 760         


<210> 7344
<211> 486
<212> PRT
<213> Homo sapiens

<400> 7344
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Trp Leu Leu Arg Phe Lys 
145                 150                 155                 160 


Val Ser Thr Gln Asn Met Lys Met Gly Gly Leu Pro Arg Thr Thr Pro 
                165                 170                 175     


Pro Thr Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Thr Leu 
            180                 185                 190         


Gly Arg His Ser Pro Tyr Arg Thr Leu Glu Pro Val Arg Pro Pro Val 
        195                 200                 205             


Val Pro Asn Asp Tyr Val Pro Ser Pro Thr Arg Asn Met Ala Pro Ser 
    210                 215                 220                 


Gln Gln Ser Pro Val Arg Thr Ala Ser Val Asn Gln Arg Asn Arg Thr 
225                 230                 235                 240 


Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser 
                245                 250                 255     


Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala 
            260                 265                 270         


Val Pro Thr Pro Ser Pro Pro Ser Val Phe Pro Ala Pro Ala Gly Ser 
        275                 280                 285             


Ala Gly Thr Pro Pro Leu Pro Ala Thr Ser Ala Ser Ala Pro Ala Pro 
    290                 295                 300                 


Leu Val Pro Ala Thr Val Pro Ser Ser Thr Ala Pro Asp Ala Ala Ala 
305                 310                 315                 320 


Gly Gly Ala Gln Thr Leu Ala Asp Gly Phe Thr Ser Pro Thr Pro Pro 
                325                 330                 335     


Val Val Ser Ser Thr Pro Pro Thr Gly His Pro Val Gln Phe Tyr Ser 
            340                 345                 350         


Met Asn Arg Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser 
        355                 360                 365             


Leu Pro Tyr Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln 
    370                 375                 380                 


Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp 
385                 390                 395                 400 


Thr Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser 
                405                 410                 415     


Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala 
            420                 425                 430         


Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala 
        435                 440                 445             


Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys 
    450                 455                 460                 


Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val 
465                 470                 475                 480 


Ile Lys Lys Asn Asp Asp 
                485     


<210> 7345
<211> 714
<212> PRT
<213> Homo sapiens

<400> 7345
Met Leu Ser Pro Lys Ile Arg Gln Ala Arg Arg Ala Arg Ser Lys Ser 
1               5                   10                  15      


Leu Val Met Gly Glu Gln Ser Arg Ser Pro Gly Arg Met Pro Cys Pro 
            20                  25                  30          


His Arg Leu Gly Pro Val Leu Lys Ala Gly Trp Leu Lys Lys Gln Arg 
        35                  40                  45              


Ser Ile Met Lys Asn Trp Gln Gln Arg Trp Phe Val Leu Arg Gly Asp 
    50                  55                  60                  


Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu Ile Lys Pro Gln Gly Phe 
65                  70                  75                  80  


Ile Ser Leu Gln Gly Thr Gln Val Thr Glu Leu Pro Pro Gly Pro Glu 
                85                  90                  95      


Asp Pro Gly Lys His Leu Phe Glu Ile Ser Pro Gly Gly Ala Gly Glu 
            100                 105                 110         


Arg Glu Lys Val Pro Ala Asn Pro Glu Ala Leu Leu Leu Met Ala Ser 
        115                 120                 125             


Ser Gln Arg Asp Met Glu Asp Trp Val Gln Ala Ile Arg Arg Val Ile 
    130                 135                 140                 


Trp Ala Pro Leu Gly Gly Gly Thr Ala Arg Arg Ser His Ala His Pro 
145                 150                 155                 160 


Leu Glu Pro Leu Pro Pro Gly Ile Phe Gly Gln Arg Leu Glu Glu Thr 
                165                 170                 175     


Val His His Glu Arg Lys Tyr Gly Pro Arg Leu Ala Pro Leu Leu Val 
            180                 185                 190         


Glu Gln Cys Val Asp Phe Ile Arg Glu Arg Gly Leu Thr Glu Glu Gly 
        195                 200                 205             


Leu Phe Arg Met Pro Gly Gln Ala Asn Leu Val Arg Asp Leu Gln Asp 
    210                 215                 220                 


Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe Asp Ser Thr Thr Asp Val 
225                 230                 235                 240 


His Thr Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu 
                245                 250                 255     


Pro Val Val Pro Phe Ala Arg Tyr Glu Asp Phe Leu Ser Cys Ala Gln 
            260                 265                 270         


Leu Leu Thr Lys Asp Glu Gly Glu Gly Thr Leu Glu Leu Ala Lys Gln 
        275                 280                 285             


Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn Leu Leu Arg Tyr Ile Cys 
    290                 295                 300                 


Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn Lys Met Ser 
305                 310                 315                 320 


Val Gln Asn Leu Ala Thr Val Phe Gly Pro Asn Ile Leu Arg Pro Gln 
                325                 330                 335     


Val Glu Asp Pro Val Thr Ile Met Glu Gly Thr Ser Leu Val Gln His 
            340                 345                 350         


Leu Met Thr Val Leu Ile Arg Lys His Ser Gln Leu Phe Thr Ala Pro 
        355                 360                 365             


Val Pro Glu Gly Pro Thr Ser Pro Arg Gly Gly Leu Gln Cys Ala Val 
    370                 375                 380                 


Gly Trp Gly Ser Glu Glu Val Thr Arg Asp Ser Gln Gly Glu Pro Gly 
385                 390                 395                 400 


Gly Pro Gly Leu Pro Ala His Arg Thr Ser Ser Leu Asp Gly Ala Ala 
                405                 410                 415     


Val Ala Val Leu Ser Arg Thr Ala Pro Thr Gly Pro Gly Ser Arg Cys 
            420                 425                 430         


Ser Pro Gly Lys Lys Val Gln Thr Leu Pro Ser Trp Lys Ser Ser Phe 
        435                 440                 445             


Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly Gly Ser Ser 
    450                 455                 460                 


Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu Met Asn Gly 
465                 470                 475                 480 


Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly Asp Arg Leu 
                485                 490                 495     


Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Thr Tyr Asp Asn Val Pro 
            500                 505                 510         


Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser Met Ala Trp 
        515                 520                 525             


Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser Leu Ser Ser 
    530                 535                 540                 


Cys Thr Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser Ser Leu His 
545                 550                 555                 560 


Thr Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser Ser Glu Asp 
                565                 570                 575     


Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala Gly Ala Gly 
            580                 585                 590         


Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Thr Arg Glu His 
        595                 600                 605             


Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Thr Glu Leu Arg Ala 
    610                 615                 620                 


Glu Leu Cys Arg Gln Arg Thr Glu Tyr Glu Arg Ser Val Lys Arg Ile 
625                 630                 635                 640 


Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg Leu Glu Glu 
                645                 650                 655     


Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu Ile Lys Leu 
            660                 665                 670         


Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg Asn Gln Leu 
        675                 680                 685             


Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Thr Leu Gly Ser Leu Thr 
    690                 695                 700                 


Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
705                 710                 


<210> 7346
<211> 126
<212> PRT
<213> Homo sapiens

<400> 7346
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr 
        115                 120                 125     


<210> 7347
<211> 813
<212> PRT
<213> Homo sapiens

<400> 7347
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Glu Ser Ile His Leu Gln Leu Ser Ser 
                85                  90                  95      


Phe Ser Ser Leu Gln Glu Glu Asp Lys Ser Arg Lys Asp Asp Ser Glu 
            100                 105                 110         


Arg Glu Lys Glu Lys Asp Lys Asn Lys Asp Lys Thr Ser Glu Lys Pro 
        115                 120                 125             


Lys Ile Arg Met Leu Ser Lys Asp Cys Ser Gln Glu Tyr Thr Asp Ser 
    130                 135                 140                 


Thr Gly Ile Asp Leu His Glu Phe Leu Ile Asn Thr Leu Lys Asn Asn 
145                 150                 155                 160 


Ser Arg Asp Arg Met Ile Leu Leu Lys Met Glu Gln Glu Ile Ile Asp 
                165                 170                 175     


Phe Ile Ala Asp Asn Asn Asn His Tyr Lys Lys Phe Pro Gln Met Ser 
            180                 185                 190         


Ser Tyr Gln Arg Met Leu Val His Arg Val Ala Ala Tyr Phe Gly Leu 
        195                 200                 205             


Asp His Asn Val Asp Gln Thr Gly Lys Ser Val Ile Ile Asn Lys Thr 
    210                 215                 220                 


Ser Ser Thr Arg Ile Pro Glu Gln Arg Phe Cys Glu His Leu Lys Asp 
225                 230                 235                 240 


Glu Lys Gly Glu Glu Ser Gln Lys Arg Phe Ile Leu Lys Arg Asp Asn 
                245                 250                 255     


Ser Ser Ile Asp Lys Glu Asp Asn Gln Ser Val Cys Ser Gln Glu Ser 
            260                 265                 270         


Leu Phe Val Glu Asn Ser Arg Leu Leu Glu Asp Ser Asn Ile Cys Asn 
        275                 280                 285             


Glu Thr Tyr Lys Lys Arg Gln Leu Phe Arg Gly Asn Arg Asp Gly Ser 
    290                 295                 300                 


Gly Arg Thr Ser Gly Ser Arg Gln Ser Ser Ser Glu Asn Glu Leu Lys 
305                 310                 315                 320 


Trp Ser Asp His Gln Arg Ala Trp Ser Ser Thr Asp Ser Asp Ser Ser 
                325                 330                 335     


Asn Arg Asn Leu Lys Pro Ala Met Thr Lys Thr Ala Ser Phe Gly Gly 
            340                 345                 350         


Ile Thr Val Leu Thr Arg Gly Asp Ser Thr Ser Ser Thr Arg Ser Thr 
        355                 360                 365             


Gly Lys Leu Ser Lys Ala Gly Ser Glu Ser Ser Ser Ser Ala Gly Ser 
    370                 375                 380                 


Ser Gly Ser Leu Ser Arg Thr His Pro Pro Leu Gln Ser Thr Pro Leu 
385                 390                 395                 400 


Val Ser Gly Val Ala Ala Gly Ser Pro Gly Cys Val Pro Tyr Pro Glu 
                405                 410                 415     


Asn Gly Ile Gly Gly Gln Val Ala Pro Ser Ser Thr Ser Tyr Ile Leu 
            420                 425                 430         


Leu Pro Leu Glu Ala Ala Thr Gly Ile Pro Pro Gly Ser Ile Leu Leu 
        435                 440                 445             


Asn Pro His Thr Gly Gln Pro Phe Val Asn Pro Asp Gly Thr Pro Ala 
    450                 455                 460                 


Ile Tyr Asn Pro Pro Thr Ser Gln Gln Pro Leu Arg Ser Ala Met Val 
465                 470                 475                 480 


Gly Gln Ser Gln Gln Gln Pro Pro Gln Gln Gln Pro Ser Pro Gln Pro 
                485                 490                 495     


Gln Gln Gln Val Gln Pro Pro Gln Pro Gln Met Ala Gly Pro Leu Val 
            500                 505                 510         


Thr Gln Ser Val Gln Gly Leu Gln Ala Ser Ser Gln Ser Val Gln Tyr 
        515                 520                 525             


Pro Ala Val Ser Phe Pro Pro Gln His Leu Leu Pro Val Ser Pro Thr 
    530                 535                 540                 


Gln His Phe Pro Met Arg Asp Asp Val Ala Thr Gln Phe Gly Gln Met 
545                 550                 555                 560 


Thr Leu Ser Arg Gln Ser Ser Gly Glu Thr Pro Glu Pro Pro Ser Gly 
                565                 570                 575     


Pro Val Tyr Pro Ser Ser Leu Met Pro Gln Pro Ala Gln Gln Pro Ser 
            580                 585                 590         


Tyr Val Ile Ala Ser Thr Gly Gln Gln Leu Pro Thr Gly Gly Phe Ser 
        595                 600                 605             


Gly Ser Gly Pro Pro Ile Ser Gln Gln Val Leu Gln Pro Pro Pro Ser 
    610                 615                 620                 


Pro Gln Gly Phe Val Gln Gln Pro Pro Pro Ala Gln Met Pro Val Tyr 
625                 630                 635                 640 


Tyr Tyr Pro Ser Gly Gln Tyr Pro Thr Ser Thr Thr Gln Gln Tyr Arg 
                645                 650                 655     


Pro Met Ala Pro Val Gln Tyr Asn Ala Gln Arg Ser Gln Gln Met Pro 
            660                 665                 670         


Gln Ala Ala Gln Gln Ala Gly Tyr Gln Pro Val Leu Ser Gly Gln Gln 
        675                 680                 685             


Gly Phe Gln Gly Leu Ile Gly Val Gln Gln Pro Pro Gln Ser Gln Asn 
    690                 695                 700                 


Val Ile Asn Asn Gln Gln Gly Thr Pro Val Gln Ser Val Met Val Ser 
705                 710                 715                 720 


Tyr Pro Thr Met Ser Ser Tyr Gln Val Pro Met Thr Gln Gly Ser Gln 
                725                 730                 735     


Gly Leu Pro Gln Gln Ser Tyr Gln Gln Pro Ile Met Leu Pro Asn Gln 
            740                 745                 750         


Ala Gly Gln Gly Ser Leu Pro Ala Thr Gly Met Pro Val Tyr Cys Asn 
        755                 760                 765             


Val Thr Pro Pro Thr Pro Gln Asn Asn Leu Arg Leu Ile Gly Pro His 
    770                 775                 780                 


Cys Pro Ser Ser Thr Val Pro Val Met Ser Ala Ser Cys Arg Thr Asn 
785                 790                 795                 800 


Cys Ala Ser Met Ser Asn Ala Gly Trp Gln Val Lys Phe 
                805                 810             


<210> 7348
<211> 488
<212> PRT
<213> Homo sapiens

<400> 7348
Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu 
            20                  25                  30          


Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu 
        195                 200                 205             


Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly 
225                 230                 235                 240 


Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu 
                245                 250                 255     


Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser 
            260                 265                 270         


Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu 
        275                 280                 285             


Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala 
    290                 295                 300                 


Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Gly Thr 
                325                 330                 335     


Ile Asn Ser Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr Gly Leu 
            340                 345                 350         


Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala Tyr Ser 
        355                 360                 365             


Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu Gly Pro 
385                 390                 395                 400 


Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp 
                405                 410                 415     


Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile Ser Ala 
            420                 425                 430         


Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe 
        435                 440                 445             


Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln Ala Met 
    450                 455                 460                 


Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg 
465                 470                 475                 480 


Ser Lys Asn Asp Ser Lys Pro Tyr 
                485             


<210> 7349
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7349
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 7350
<211> 100
<212> PRT
<213> Homo sapiens

<400> 7350
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe 
        35                  40                  45              


Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu 
    50                  55                  60                  


Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys 
65                  70                  75                  80  


Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile 
                85                  90                  95      


Pro Pro Ala Leu 
            100 


<210> 7351
<211> 152
<212> PRT
<213> Homo sapiens

<400> 7351
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val 
145                 150         


<210> 7352
<211> 180
<212> PRT
<213> Homo sapiens

<400> 7352
Met Phe Ala Ser Asp Leu Leu Arg Ala Leu Asp Cys Cys Pro Gly Ala 
1               5                   10                  15      


Gly Ser Ser Gly Leu Leu Pro Gln Leu Gly Pro Arg Gln Leu Leu Ala 
            20                  25                  30          


Phe Thr Val Asn Cys Leu Gly Asn His Arg Tyr Leu Gly Phe Phe Glu 
        35                  40                  45              


Asp Leu Glu Gln Arg His Lys Ala Gln Val Leu Val Glu Asp Ile Ser 
    50                  55                  60                  


Asp Ile Leu Glu Glu His Ala Glu Lys His Phe His Pro Tyr Ile Ala 
65                  70                  75                  80  


Tyr Cys Ser Asn Glu Val Tyr Gln Gln Arg Thr Leu Gln Lys Leu Ile 
                85                  90                  95      


Ser Ser Asn Ala Ala Phe Arg Glu Ala Leu Arg Glu Ile Glu Arg Arg 
            100                 105                 110         


Pro Ala Cys Gly Gly Leu Pro Met Leu Ser Phe Leu Ile Leu Pro Met 
        115                 120                 125             


Gln Arg Val Thr Arg Leu Pro Leu Leu Met Asp Thr Leu Cys Leu Lys 
    130                 135                 140                 


Thr Gln Gly His Ser Glu Arg Tyr Lys Ala Ala Ser Arg Ala Leu Lys 
145                 150                 155                 160 


Ala Ile Ser Lys Leu Val Arg Gln Cys Asn Glu Gly Ala His Arg Met 
                165                 170                 175     


Glu Arg Met Glu 
            180 


<210> 7353
<211> 828
<212> PRT
<213> Homo sapiens

<400> 7353
Met Asp Ser Glu Ala Phe Gln Ser Ala Arg Asp Phe Leu Asp Met Asn 
1               5                   10                  15      


Phe Gln Ser Leu Ala Met Lys His Met Asp Leu Lys Gln Met Glu Leu 
            20                  25                  30          


Asp Thr Ala Ala Ala Lys Val Asp Glu Leu Thr Lys Gln Leu Glu Ser 
        35                  40                  45              


Leu Trp Ser Asp Ser Pro Ala Pro Pro Gly Pro Gln Ala Gly Pro Pro 
    50                  55                  60                  


Ser Arg Pro Pro Arg Tyr Ser Ser Ser Ser Ile Pro Glu Pro Phe Gly 
65                  70                  75                  80  


Ser Arg Gly Ser Pro Arg Lys Ala Ala Thr Asp Gly Ala Asp Thr Pro 
                85                  90                  95      


Phe Gly Arg Ser Glu Ser Ala Pro Thr Leu His Pro Tyr Ser Pro Leu 
            100                 105                 110         


Ser Pro Lys Gly Arg Pro Ser Ser Pro Arg Thr Pro Leu Tyr Leu Gln 
        115                 120                 125             


Pro Asp Ala Tyr Gly Ser Leu Asp Arg Ala Thr Ser Pro Arg Pro Arg 
    130                 135                 140                 


Ala Phe Asp Gly Ala Gly Ser Ser Leu Gly Arg Ala Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Gly Pro Gly Pro Leu Arg Gln Gln Gly Pro Pro Thr Pro Phe Asp 
                165                 170                 175     


Phe Leu Gly Arg Ala Gly Ser Pro Arg Gly Ser Pro Leu Ala Glu Gly 
            180                 185                 190         


Pro Gln Ala Phe Phe Pro Glu Arg Gly Pro Ser Pro Arg Pro Pro Ala 
        195                 200                 205             


Thr Ala Tyr Asp Ala Pro Ala Ser Ala Phe Gly Ser Ser Leu Leu Gly 
    210                 215                 220                 


Ser Gly Gly Ser Ala Phe Ala Pro Pro Leu Arg Ala Gln Asp Asp Leu 
225                 230                 235                 240 


Thr Leu Arg Arg Arg Pro Pro Lys Ala Trp Asn Glu Ser Asp Leu Asp 
                245                 250                 255     


Val Ala Tyr Glu Lys Lys Pro Ser Gln Thr Ala Ser Tyr Glu Arg Leu 
            260                 265                 270         


Asp Val Phe Ala Arg Pro Ala Ser Pro Ser Leu Gln Leu Leu Pro Trp 
        275                 280                 285             


Arg Glu Ser Ser Leu Asp Gly Leu Gly Gly Thr Gly Lys Asp Asn Leu 
    290                 295                 300                 


Thr Ser Ala Thr Leu Pro Arg Asn Tyr Lys Val Ser Pro Leu Ala Ser 
305                 310                 315                 320 


Asp Arg Arg Ser Asp Ala Gly Ser Tyr Arg Arg Ser Leu Gly Ser Ala 
                325                 330                 335     


Gly Pro Ser Gly Thr Leu Pro Arg Ser Trp Gln Pro Val Ser Arg Ile 
            340                 345                 350         


Pro Met Pro Pro Ser Ser Pro Gln Pro Arg Gly Ala Pro Arg Gln Arg 
        355                 360                 365             


Pro Ile Pro Leu Ser Met Ile Phe Lys Leu Gln Asn Ala Phe Trp Glu 
    370                 375                 380                 


His Gly Ala Ser Arg Ala Met Leu Pro Gly Ser Pro Leu Phe Thr Arg 
385                 390                 395                 400 


Ala Pro Pro Pro Lys Leu Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro 
                405                 410                 415     


Gln Ser Gln Pro Gln Pro Gln Leu Pro Pro Gln Pro Gln Thr Gln Pro 
            420                 425                 430         


Gln Thr Pro Thr Pro Ala Pro Gln His Pro Gln Gln Thr Trp Pro Pro 
        435                 440                 445             


Val Asn Glu Gly Pro Pro Lys Pro Pro Thr Glu Leu Glu Pro Glu Pro 
    450                 455                 460                 


Glu Ile Glu Gly Leu Leu Thr Pro Val Leu Glu Ala Gly Asp Val Asp 
465                 470                 475                 480 


Glu Gly Pro Val Ala Arg Pro Leu Ser Pro Thr Arg Leu Gln Pro Ala 
                485                 490                 495     


Leu Pro Pro Glu Ala Gln Ser Val Pro Glu Leu Glu Glu Val Ala Arg 
            500                 505                 510         


Val Leu Ala Glu Ile Pro Arg Pro Leu Lys Arg Arg Gly Ser Met Glu 
        515                 520                 525             


Gln Ala Pro Ala Val Ala Leu Pro Pro Thr His Lys Lys Gln Tyr Gln 
    530                 535                 540                 


Gln Ile Ile Ser Arg Leu Phe His Arg His Gly Gly Pro Gly Pro Gly 
545                 550                 555                 560 


Gly Pro Glu Pro Glu Leu Ser Pro Ile Thr Glu Gly Ser Glu Ala Arg 
                565                 570                 575     


Ala Gly Pro Pro Ala Pro Ala Pro Pro Ala Pro Ile Pro Pro Pro Ala 
            580                 585                 590         


Pro Ser Gln Ser Ser Pro Pro Glu Gln Pro Gln Ser Met Glu Met Arg 
        595                 600                 605             


Ser Val Leu Arg Lys Ala Gly Ser Pro Arg Lys Ala Arg Arg Ala Arg 
    610                 615                 620                 


Leu Asn Pro Leu Val Leu Leu Leu Asp Ala Ala Leu Thr Gly Glu Leu 
625                 630                 635                 640 


Glu Val Val Gln Gln Ala Val Lys Glu Met Asn Asp Pro Ser Gln Pro 
                645                 650                 655     


Asn Glu Glu Gly Ile Thr Ala Leu His Asn Ala Ile Cys Gly Ala Asn 
            660                 665                 670         


Tyr Ser Ile Val Asp Phe Leu Ile Thr Ala Gly Ala Asn Val Asn Ser 
        675                 680                 685             


Pro Asp Ser His Gly Trp Thr Pro Leu His Cys Ala Ala Ser Cys Asn 
    690                 695                 700                 


Asp Thr Val Ile Cys Met Ala Leu Val Gln His Gly Ala Ala Ile Phe 
705                 710                 715                 720 


Ala Thr Thr Leu Ser Asp Gly Ala Thr Ala Phe Glu Lys Cys Asp Pro 
                725                 730                 735     


Tyr Arg Glu Gly Tyr Ala Asp Cys Ala Thr Tyr Leu Ala Asp Val Glu 
            740                 745                 750         


Gln Ser Met Gly Leu Met Asn Ser Gly Ala Val Tyr Ala Leu Trp Asp 
        755                 760                 765             


Tyr Ser Ala Glu Phe Gly Asp Glu Leu Ser Phe Arg Glu Gly Glu Ser 
    770                 775                 780                 


Val Thr Val Leu Arg Arg Asp Gly Pro Glu Glu Thr Asp Trp Trp Trp 
785                 790                 795                 800 


Ala Ala Leu His Gly Gln Glu Gly Tyr Val Pro Arg Asn Tyr Phe Gly 
                805                 810                 815     


Leu Phe Pro Arg Val Lys Pro Gln Arg Ser Lys Val 
            820                 825             


<210> 7354
<211> 1484
<212> PRT
<213> Homo sapiens

<400> 7354
Met Arg Ile Pro Asp Gln Lys Tyr Val Thr Leu Lys Leu Asn Asp Val 
1               5                   10                  15      


Ile Arg Phe Gly Tyr Asp Ser Asn Met Tyr Val Leu Glu Arg Val Gln 
            20                  25                  30          


His Arg Val Pro Glu Glu Ala Leu Lys His Glu Lys Tyr Thr Ser Gln 
        35                  40                  45              


Leu Gln Val Ser Val Lys Gly Leu Ala Pro Lys Arg Ser Glu Ala Leu 
    50                  55                  60                  


Pro Glu His Thr Pro Tyr Cys Glu Ala Ser Asn Pro Arg Pro Glu Lys 
65                  70                  75                  80  


Gly Asp Arg Arg Pro Gly Thr Glu Ala Ala Ser Tyr Arg Thr Pro Leu 
                85                  90                  95      


Tyr Gly Gln Pro Ser Trp Trp Gly Glu Asp Asp Gly Ser Thr Leu Pro 
            100                 105                 110         


Asp Ala Gln Arg Gln Gly Glu Pro Tyr Pro Glu Arg Pro Lys Gly Pro 
        115                 120                 125             


Val Gln Gln Asp Gly Glu Leu His Gly Phe Arg Ala Pro Ala Glu Pro 
    130                 135                 140                 


Gln Gly Cys Ser Phe Arg Arg Glu Pro Ser Tyr Phe Glu Ile Pro Thr 
145                 150                 155                 160 


Lys Glu Thr Pro Gln Pro Ser Gln Pro Pro Glu Val Pro Ala His Glu 
                165                 170                 175     


Met Pro Thr Lys Asp Ala Glu Ala Gly Gly Gly Gly Ala Ala Pro Val 
            180                 185                 190         


Val Gln Ser His Ala Ser Phe Thr Ile Glu Phe Asp Asp Cys Ser Pro 
        195                 200                 205             


Gly Lys Met Lys Ile Lys Asp His Ile Thr Lys Phe Ser Leu Arg Gln 
    210                 215                 220                 


Arg Arg Pro Pro Gly Lys Glu Ala Thr Pro Gly Glu Met Val Ser Ala 
225                 230                 235                 240 


Glu Thr Lys Val Ala Asp Trp Leu Val Gln Asn Asp Pro Ser Leu Leu 
                245                 250                 255     


His Arg Val Gly Pro Gly Asp Asp Arg His Ser Thr Lys Ser Asp Leu 
            260                 265                 270         


Pro Val His Thr Arg Thr Leu Lys Gly His Lys His Glu Asp Gly Thr 
        275                 280                 285             


Gln Ser Asp Ser Glu Asp Pro Leu Ala Lys Ala Ala Ser Ala Ala Gly 
    290                 295                 300                 


Val Pro Leu Glu Ala Ser Gly Glu Gln Val Arg Leu Gln Arg Gln Ile 
305                 310                 315                 320 


Lys Arg Asp Pro Gln Glu Leu Leu His Asn Gln Gln Ala Phe Val Ile 
                325                 330                 335     


Glu Phe Phe Asp Glu Asp Thr Pro Arg Lys Lys Arg Ser Gln Ser Phe 
            340                 345                 350         


Thr His Ser Pro Ser Gly Asp Pro Lys Ala Asp Lys Arg Arg Gly Pro 
        355                 360                 365             


Thr Pro Ala Asp Arg Asp Arg Pro Ser Val Pro Ala Pro Val Gln Ala 
    370                 375                 380                 


Gly Gly Arg Ser Ser Gly Pro Gln Arg Ala Gly Ser Leu Lys Arg Glu 
385                 390                 395                 400 


Lys Thr Glu Glu Arg Leu Gly Ser Pro Ser Pro Ala Ser Arg Thr Pro 
                405                 410                 415     


Ala Arg Pro Phe Gly Ser Val Gly Arg Arg Ser Arg Leu Ala Gln Asp 
            420                 425                 430         


Phe Met Ala Gln Cys Leu Arg Glu Ser Ser Pro Ala Ala Arg Pro Ser 
        435                 440                 445             


Pro Glu Lys Val Pro Pro Val Leu Pro Ala Pro Leu Thr Pro His Gly 
    450                 455                 460                 


Thr Ser Pro Val Gly Pro Pro Thr Pro Pro Pro Ala Pro Thr Asp Pro 
465                 470                 475                 480 


Gln Leu Thr Lys Ala Arg Lys Gln Glu Glu Asp Asp Ser Leu Ser Asp 
                485                 490                 495     


Ala Gly Thr Tyr Thr Ile Glu Thr Glu Ala Gln Asp Thr Glu Val Glu 
            500                 505                 510         


Glu Ala Arg Lys Met Ile Asp Gln Val Phe Gly Val Leu Glu Ser Pro 
        515                 520                 525             


Glu Leu Ser Arg Ala Ser Ser Ala Thr Phe Arg Pro Val Ile Arg Gly 
    530                 535                 540                 


Asp Arg Asp Glu Ser Asp Asp Gly Gly Val Ala Gln Arg Met Ala Leu 
545                 550                 555                 560 


Leu Gln Glu Phe Ala Ser Arg Pro Leu Gly Ala Ala Pro Gln Ala Glu 
                565                 570                 575     


His Gln Gly Leu Pro Val Pro Gly Ser Pro Gly Gly Gln Lys Trp Val 
            580                 585                 590         


Ser Arg Trp Ala Ser Leu Ala Asp Ser Tyr Ser Asp Pro Gly Leu Thr 
        595                 600                 605             


Glu Asp Gly Leu Gly Arg Arg Gly Gly Glu Pro Glu Gly Ser Leu Pro 
    610                 615                 620                 


Val Arg Met Arg Arg Arg Leu Pro Gln Leu Pro Ser Glu Arg Ala Asp 
625                 630                 635                 640 


Ser Pro Ala Gly Pro Glu Ser Ser Arg Arg Ser Gly Pro Gly Pro Pro 
                645                 650                 655     


Glu Leu Asp Ser Glu Gln Pro Ser Arg Leu Phe Gly Gln Glu Glu Leu 
            660                 665                 670         


Asp Pro Asp Ser Leu Ser Asp Ala Ser Gly Ser Asp Gly Gly Arg Gly 
        675                 680                 685             


Pro Glu Pro Gly Val Glu Pro Gln Asp Ser Arg Arg Arg Ser Pro Gln 
    690                 695                 700                 


Glu Gly Pro Thr Trp Ser Arg Gly Arg Arg Ser Pro Arg Ala Pro Gly 
705                 710                 715                 720 


Glu Pro Thr Pro Ala Ser Phe Phe Ile Gly Asp Gln Asn Gly Asp Ala 
                725                 730                 735     


Val Leu Ser Arg Lys Pro Leu Ala Ala Pro Gly Asp Gly Glu Gly Leu 
            740                 745                 750         


Gly Gln Thr Ala Gln Pro Ser Pro Pro Ala Arg Asp Gly Val Tyr Val 
        755                 760                 765             


Ser Ala Asn Gly Arg Met Val Ile Gln Leu Arg Pro Gly Arg Ser Pro 
    770                 775                 780                 


Glu Pro Asp Gly Pro Ala Pro Ala Phe Leu Arg Gln Glu Ser Phe Thr 
785                 790                 795                 800 


Lys Glu Pro Ala Ser Gly Pro Pro Ala Pro Gly Lys Pro Pro His Ile 
                805                 810                 815     


Ser Ser His Pro Leu Leu Gln Asp Leu Ala Ala Thr Arg Ala Ala Arg 
            820                 825                 830         


Met Asp Phe His Ser Gln Asp Thr His Leu Ile Leu Lys Glu Thr Glu 
        835                 840                 845             


Thr Ala Leu Ala Ala Leu Glu Ala Arg Leu Leu Ser Asn Ser Val Asp 
    850                 855                 860                 


Ala Glu Cys Glu Gly Gly Ser Thr Pro Arg Pro Pro Glu Asp Ala Leu 
865                 870                 875                 880 


Ser Gly Asp Ser Asp Val Asp Thr Ala Ser Thr Val Ser Leu Arg Ser 
                885                 890                 895     


Gly Lys Ser Gly Pro Ser Pro Thr Thr Pro Gln Pro Leu Arg Ala Gln 
            900                 905                 910         


Lys Glu Met Ser Pro Ser Pro Pro Ala Ala Gln Asp Pro Gly Gly Thr 
        915                 920                 925             


Ala Leu Val Ser Ala Arg Glu Gln Ser Ser Glu Arg Gln His His Pro 
    930                 935                 940                 


Leu Gly Pro Thr Asp Met Gly Arg Gly Glu Pro Val Arg Arg Ser Ala 
945                 950                 955                 960 


Ile Arg Arg Gly His Arg Pro Arg Gly Ser Leu Asp Trp Pro Ser Glu 
                965                 970                 975     


Glu Arg Gly Pro Val Leu Ala His Leu Pro Ser Ser Asp Val Met Ala 
            980                 985                 990         


Ser Asn His Glu Thr Pro Glu Ala  Thr Gly Ala Gly Arg  Leu Gly Ser 
        995                 1000                 1005             


Arg Arg  Lys Pro Ala Ala Pro  Pro Pro Ser Pro Ala  Ala Arg Glu 
    1010                 1015                 1020             


Glu Gln  Ser Arg Ser Ser Ala  Ser Ser Gln Lys Gly  Pro Gln Ala 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asn Ser Leu  Ser Thr Pro Arg Pro  Thr Arg Ala 
    1040                 1045                 1050             


Ser Arg  Leu Arg Arg Ala Arg  Leu Gly Asp Ala Ser  Asp Thr Glu 
    1055                 1060                 1065             


Ala Ala  Asp Gly Glu Arg Gly  Ser Leu Gly Asn Pro  Glu Pro Val 
    1070                 1075                 1080             


Gly Arg  Pro Ala Ala Glu Gln  Ala Lys Lys Leu Ser  Arg Leu Asp 
    1085                 1090                 1095             


Ile Leu  Ala Met Pro Arg Lys  Arg Ala Gly Ser Phe  Thr Gly Thr 
    1100                 1105                 1110             


Ser Asp  Pro Glu Ala Ala Pro  Ala Arg Thr Ser Phe  Ser Gly Arg 
    1115                 1120                 1125             


Ser Val  Glu Leu Cys Cys Ala  Ser Arg Lys Pro Thr  Met Ala Glu 
    1130                 1135                 1140             


Ala Arg  Ala Val Ser Arg Lys  Ala Ala Asn Thr Ala  Thr Thr Thr 
    1145                 1150                 1155             


Gly Pro  Arg Gln Pro Phe Ser  Arg Ala Arg Ser Gly  Ser Ala Arg 
    1160                 1165                 1170             


Tyr Thr  Ser Thr Thr Gln Thr  Pro Arg Ala Gly Ser  Ser Ser Arg 
    1175                 1180                 1185             


Ala Arg  Ser Arg Ala Pro Gly  Pro Arg Asp Thr Asp  Asp Asp Glu 
    1190                 1195                 1200             


Glu Glu  Pro Asp Pro Tyr Gly  Phe Ile Val Gln Thr  Ala Glu Ile 
    1205                 1210                 1215             


Ala Glu  Ile Ala Arg Leu Ser  Gln Thr Leu Val Lys  Asp Val Ala 
    1220                 1225                 1230             


Ile Leu  Ala Gln Glu Ile His  Asp Val Ala Gly Asp  Gly Asp Thr 
    1235                 1240                 1245             


Leu Gly  Ser Ser Glu Pro Ala  His Ser Ala Ser Leu  Ser Asn Met 
    1250                 1255                 1260             


Pro Ser  Thr Pro Ala Ser Thr  Ile Ser Ala Arg Glu  Glu Leu Val 
    1265                 1270                 1275             


Gln Arg  Ile Pro Glu Ala Ser  Leu Asn Phe Gln Lys  Val Pro Pro 
    1280                 1285                 1290             


Gly Ser  Leu Asn Ser Arg Asp  Phe Asp Gln Asn Met  Asn Asp Ser 
    1295                 1300                 1305             


Cys Glu  Asp Ala Leu Ala Asn  Lys Thr Arg Pro Arg  Asn Arg Glu 
    1310                 1315                 1320             


Glu Val  Ile Phe Asp Asn Leu  Met Leu Asn Pro Val  Ser Gln Leu 
    1325                 1330                 1335             


Ser Gln  Ala Ile Arg Glu Asn  Thr Glu His Leu Ala  Glu Lys Met 
    1340                 1345                 1350             


Lys Ile  Leu Phe Gln Asn Thr  Gly Arg Ala Trp Glu  Asp Leu Glu 
    1355                 1360                 1365             


Ala Arg  Ile Asn Ala Glu Asn  Glu Val Pro Ile Leu  Lys Thr Ser 
    1370                 1375                 1380             


Asn Lys  Glu Ile Ser Ser Ile  Leu Lys Glu Leu Arg  Arg Val Gln 
    1385                 1390                 1395             


Lys Gln  Leu Glu Val Ile Asn  Ala Ile Val Asp Pro  Ser Gly Ser 
    1400                 1405                 1410             


Leu Asp  Leu Leu Thr Gly Asn  Arg Ser Leu Ala Ser  Ser Ala Gln 
    1415                 1420                 1425             


Pro Gly  Leu Gly Lys Gly Arg  Val Ala Ala Gln Ser  Pro Pro Ser 
    1430                 1435                 1440             


Pro Ala  Ser Ala Glu Ala Leu  Leu Pro Ala Leu Pro  Leu Arg Asn 
    1445                 1450                 1455             


Phe Pro  Gln Arg Ala Ser Cys  Gly Pro Pro Ser Leu  Pro Asp Pro 
    1460                 1465                 1470             


Thr Phe  Leu Pro Asp Ala Glu  Arg Phe Leu Ile 
    1475                 1480                 


<210> 7355
<211> 49
<212> PRT
<213> Homo sapiens

<400> 7355
Met Tyr Pro Asn Pro Leu Ile Tyr Cys Thr Cys Trp Asp Pro Trp Asn 
1               5                   10                  15      


Leu Gly Pro Arg Lys Leu Ile Lys Thr Pro Gln Leu Pro Arg Lys Asn 
            20                  25                  30          


Ser Thr Gly Ser Ser Lys Leu Thr Pro Leu Val Pro Ala Pro Lys Asn 
        35                  40                  45              


His 
    


<210> 7356
<211> 315
<212> PRT
<213> Homo sapiens

<400> 7356
Met Ala Phe Pro Glu Pro Lys Pro Arg Pro Pro Glu Leu Pro Gln Lys 
1               5                   10                  15      


Arg Leu Lys Thr Leu Asp Cys Gly Gln Gly Ala Val Arg Ala Val Arg 
            20                  25                  30          


Phe Asn Val Asp Gly Asn Tyr Cys Leu Thr Cys Gly Ser Asp Lys Thr 
        35                  40                  45              


Leu Lys Leu Trp Asn Pro Leu Arg Gly Thr Leu Leu Arg Thr Tyr Ser 
    50                  55                  60                  


Gly His Gly Tyr Glu Val Leu Asp Ala Ala Gly Ser Phe Asp Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Ser Gly Gly Gly Asp Lys Ala Val Val Leu Trp Asp Val 
                85                  90                  95      


Ala Ser Gly Gln Val Val Arg Lys Phe Arg Gly His Ala Gly Lys Val 
            100                 105                 110         


Asn Thr Val Gln Phe Asn Glu Glu Ala Thr Val Ile Leu Ser Gly Ser 
        115                 120                 125             


Ile Asp Ser Ser Ile Arg Cys Trp Asp Cys Arg Ser Arg Arg Pro Glu 
    130                 135                 140                 


Pro Val Gln Thr Leu Asp Glu Ala Arg Asp Gly Val Ser Ser Val Lys 
145                 150                 155                 160 


Val Ser Asp His Glu Ile Leu Ala Gly Ser Val Asp Gly Arg Val Arg 
                165                 170                 175     


Arg Tyr Asp Leu Arg Met Gly Gln Leu Phe Ser Asp Tyr Val Gly Ser 
            180                 185                 190         


Pro Ile Thr Cys Thr Cys Phe Ser Arg Asp Gly Gln Cys Thr Leu Val 
        195                 200                 205             


Ser Ser Leu Asp Ser Thr Leu Arg Leu Leu Asp Lys Asp Thr Gly Glu 
    210                 215                 220                 


Leu Leu Gly Glu Tyr Lys Gly His Lys Asn Gln Glu Tyr Lys Leu Asp 
225                 230                 235                 240 


Cys Cys Leu Ser Glu Arg Asp Thr His Val Val Ser Cys Ser Glu Asp 
                245                 250                 255     


Gly Lys Val Phe Phe Trp Asp Leu Val Glu Gly Ala Leu Ala Leu Ala 
            260                 265                 270         


Leu Pro Val Gly Ser Gly Val Val Gln Ser Leu Ala Tyr His Pro Thr 
        275                 280                 285             


Glu Pro Cys Leu Leu Thr Ala Met Gly Gly Ser Val Gln Cys Trp Arg 
    290                 295                 300                 


Glu Glu Ala Tyr Glu Ala Glu Asp Gly Ala Gly 
305                 310                 315 


<210> 7357
<211> 1004
<212> PRT
<213> Homo sapiens

<400> 7357
Met Lys Ala Thr Thr Pro Leu Gln Thr Val Asp Arg Pro Lys Asp Trp 
1               5                   10                  15      


Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Gly Leu 
            20                  25                  30          


Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln 
        35                  40                  45              


Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala 
    50                  55                  60                  


Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro 
65                  70                  75                  80  


Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp 
                85                  90                  95      


Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu 
            100                 105                 110         


Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln 
        115                 120                 125             


His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu 
    130                 135                 140                 


Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg 
145                 150                 155                 160 


Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln 
                165                 170                 175     


Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser 
            180                 185                 190         


Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser 
        195                 200                 205             


Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro Ser Leu Cys Ser 
    210                 215                 220                 


Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu Asp Tyr Cys Ser 
225                 230                 235                 240 


Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser Pro Arg Ala Ile 
                245                 250                 255     


Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp 
            260                 265                 270         


Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys Ser Arg Ser Cys 
        275                 280                 285             


Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro Asp Pro Lys Val 
    290                 295                 300                 


Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu Asp Ser Lys Glu 
305                 310                 315                 320 


Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro Glu Val Arg Ser 
                325                 330                 335     


Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg Asn Ala Pro Gly 
            340                 345                 350         


Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu 
        355                 360                 365             


Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr 
    370                 375                 380                 


Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala Trp Ser Gln Cys 
385                 390                 395                 400 


Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr Arg Ile Ser Glu 
                405                 410                 415     


Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp 
            420                 425                 430         


Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys 
        435                 440                 445             


Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu Glu Glu Asn Gln 
    450                 455                 460                 


Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln Ser Asn Ala Leu 
465                 470                 475                 480 


Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Ala His 
                485                 490                 495     


Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser 
            500                 505                 510         


Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser Glu Ser Asp Phe 
        515                 520                 525             


Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His 
    530                 535                 540                 


His His His His His His His His His His Arg His Leu Ile Ser Ser 
545                 550                 555                 560 


Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu 
                565                 570                 575     


Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu Pro Arg Arg Gln 
            580                 585                 590         


Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val 
        595                 600                 605             


Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys Gln Thr Glu Lys 
    610                 615                 620                 


Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp Ser Ala Leu Lys 
625                 630                 635                 640 


Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg Gly Ser Leu Pro 
                645                 650                 655     


Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Asp Val 
            660                 665                 670         


Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg Ser Pro Leu His 
        675                 680                 685             


Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile His Cys Pro Pro 
    690                 695                 700                 


Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala Ser Phe Gln Asp 
705                 710                 715                 720 


Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp Arg Gly Gly Ala 
                725                 730                 735     


Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp 
            740                 745                 750         


Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu 
        755                 760                 765             


Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
    770                 775                 780                 


Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
785                 790                 795                 800 


Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
                805                 810                 815     


Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
            820                 825                 830         


Ala Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile 
        835                 840                 845             


Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
    850                 855                 860                 


Lys Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
865                 870                 875                 880 


Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
                885                 890                 895     


Tyr Val Glu Val Val Lys Lys Asn Thr Lys Gly Ala Glu Asp Tyr Pro 
            900                 905                 910         


Asp Pro Pro Ile Pro His Ser Tyr Ser Ser Asp Arg Ile His Ser Leu 
        915                 920                 925             


Ser Ser Asn Lys Pro Gln Arg Pro Val Phe Thr His Glu Asn Ile Gln 
    930                 935                 940                 


Gly Gly Gly Glu Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn 
945                 950                 955                 960 


Glu Asp Glu Leu Glu Leu Arg Glu Ser Asp Val Ile Asp Val Met Glu 
                965                 970                 975     


Lys Cys Asp Asp Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe 
            980                 985                 990         


Phe Gly Thr Phe Pro Gly Asn Tyr  Val Lys Arg Leu 
        995                 1000                 


<210> 7358
<211> 326
<212> PRT
<213> Homo sapiens

<400> 7358
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Pro Ser Val Met Ala Cys 
            20                  25                  30          


Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile Leu 
        35                  40                  45              


Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg Pro 
    50                  55                  60                  


Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn Ile 
65                  70                  75                  80  


Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu Lys 
                85                  90                  95      


Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe Lys 
            100                 105                 110         


Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly Gly 
        115                 120                 125             


Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu Ile 
    130                 135                 140                 


Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His Thr 
145                 150                 155                 160 


Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn Gly 
                165                 170                 175     


Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr Glu 
            180                 185                 190         


Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala Thr 
        195                 200                 205             


Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln His 
    210                 215                 220                 


Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu Tyr 
225                 230                 235                 240 


Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile Leu 
                245                 250                 255     


Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr Asp 
            260                 265                 270         


Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu Met 
        275                 280                 285             


Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln Phe 
    290                 295                 300                 


Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg Arg 
305                 310                 315                 320 


Met Arg Gly Leu Phe Phe 
                325     


<210> 7359
<211> 259
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7359
Xaa Phe Thr Ala Gln Ala Pro Ser Gly Arg Gly Ala Ala Val Gly Ser 
1               5                   10                  15      


Gly Thr Arg Leu Ala Ser Leu Arg Leu Leu Thr Glu Leu Glu Ser Pro 
            20                  25                  30          


Ala Trp Trp Pro Phe Ser Ser Lys Leu Trp Lys Thr Pro Pro Glu Thr 
        35                  40                  45              


Lys Pro Arg Glu Asp Val Ser Met Thr Ser Cys Glu Pro Phe Gly Lys 
    50                  55                  60                  


Glu Gly Ile Leu Ile Lys Ile Pro Ala Val Ile Ser His Arg Thr Glu 
65                  70                  75                  80  


Ser His Val Lys Pro Gly Arg Leu Thr Val Leu Val Ser Gly Leu Glu 
                85                  90                  95      


Ile His Asp Ser Ser Ser Leu Leu Met His Arg Phe Glu Arg Glu Asp 
            100                 105                 110         


Val Asp Asp Ile Lys Val His Ser Pro Tyr Glu Ile Ser Ile Arg Gln 
        115                 120                 125             


Arg Phe Ile Gly Lys Pro Asp Met Ala Tyr Arg Leu Ile Ser Ala Lys 
    130                 135                 140                 


Met Pro Glu Val Ile Pro Ile Leu Glu Val Gln Phe Ser Lys Lys Met 
145                 150                 155                 160 


Glu Leu Leu Glu Asp Ala Leu Val Leu Arg Ser Ala Arg Thr Ser Ser 
                165                 170                 175     


Pro Ala Glu Lys Ser Cys Ser Val Trp His Ala Ala Ser Gly Leu Met 
            180                 185                 190         


Gly Arg Thr Leu His Arg Glu Pro Pro Ala Gly Asp Gln Glu Gly Thr 
        195                 200                 205             


Ala Leu His Leu Gln Thr Ser Leu Pro Ala Leu Ser Glu Ala Asp Thr 
    210                 215                 220                 


Gln Glu Leu Thr Gln Gly Phe Arg Pro Met Ser Leu Ser Thr Gln Thr 
225                 230                 235                 240 


Val Leu Val Met Leu Cys Ser Glu Ser Ala Gly Ala Leu Trp Arg Gln 
                245                 250                 255     


Arg Leu Ser 
            


<210> 7360
<211> 345
<212> PRT
<213> Homo sapiens

<400> 7360
Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu 
    290                 295                 300                 


Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro 
305                 310                 315                 320 


Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp 
                325                 330                 335     


Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345 


<210> 7361
<211> 31
<212> PRT
<213> Homo sapiens

<400> 7361
Met Thr Val Pro Trp Arg Pro Gly Lys Arg Arg Ile Thr Tyr Lys Glu 
1               5                   10                  15      


Glu Glu Asp Leu Thr Leu Gln Pro Arg Ser Cys Leu Gln Cys Ser 
            20                  25                  30      


<210> 7362
<211> 162
<212> PRT
<213> Homo sapiens

<400> 7362
Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe 
1               5                   10                  15      


Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe 
            20                  25                  30          


Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu 
        35                  40                  45              


Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg 
    50                  55                  60                  


Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu 
65                  70                  75                  80  


Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys 
                85                  90                  95      


Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln 
            100                 105                 110         


Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe 
        115                 120                 125             


Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu 
    130                 135                 140                 


Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn 
145                 150                 155                 160 


Gly Thr 
        


<210> 7363
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7363
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn 
                85                  


<210> 7364
<211> 674
<212> PRT
<213> Homo sapiens

<400> 7364
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met 
            100                 105                 110         


Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser 
        115                 120                 125             


Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr 
    130                 135                 140                 


Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser 
145                 150                 155                 160 


Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe 
                165                 170                 175     


Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met 
            180                 185                 190         


Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly 
        195                 200                 205             


Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val 
    210                 215                 220                 


Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val 
225                 230                 235                 240 


Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln 
                245                 250                 255     


Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro 
            260                 265                 270         


Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu 
        275                 280                 285             


Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val 
    290                 295                 300                 


Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser 
305                 310                 315                 320 


Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile 
                325                 330                 335     


Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln 
            340                 345                 350         


Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro 
        355                 360                 365             


Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile 
    370                 375                 380                 


Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp 
385                 390                 395                 400 


Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile 
                405                 410                 415     


Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly 
            420                 425                 430         


Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser 
    450                 455                 460                 


Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys 
465                 470                 475                 480 


Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val 
                485                 490                 495     


Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly 
            500                 505                 510         


Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu 
        515                 520                 525             


Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala 
    530                 535                 540                 


Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val 
545                 550                 555                 560 


Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile 
                565                 570                 575     


Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu 
            580                 585                 590         


Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met 
        595                 600                 605             


Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln 
    610                 615                 620                 


Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala 
625                 630                 635                 640 


Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser 
                645                 650                 655     


Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys 
            660                 665                 670         


Gly Lys 
        


<210> 7365
<211> 640
<212> PRT
<213> Homo sapiens

<400> 7365
Met Glu Asn Gln Leu Ala Lys Ser Thr Glu Glu Arg Thr Phe Gln Tyr 
1               5                   10                  15      


Gln Asp Ser Leu Pro Ser Leu Pro Val Pro Ser Leu Glu Glu Ser Leu 
            20                  25                  30          


Lys Lys Tyr Leu Glu Ser Val Thr Arg Thr Cys Tyr Gln Ile Arg Gly 
        35                  40                  45              


Leu Asp Pro Asp Ala Lys Arg Gly Phe Leu Asp Leu Thr Arg Glu Gly 
    50                  55                  60                  


Ile Gln Val Lys Pro Phe Ala Asn Gln Glu Glu Tyr Lys Lys Thr Glu 
65                  70                  75                  80  


Glu Ile Val Gln Lys Phe Gln Ser Gly Ile Gly Glu Lys Leu His Gln 
                85                  90                  95      


Lys Leu Leu Glu Arg Ala Lys Gly Lys Arg Asn Trp Leu Glu Glu Trp 
            100                 105                 110         


Trp Leu Asn Val Ala Tyr Leu Asp Val Arg Ile Pro Ser Gln Leu Asn 
        115                 120                 125             


Val Asn Phe Ala Gly Pro Ala Ala His Phe Glu His Tyr Trp Pro Pro 
    130                 135                 140                 


Lys Glu Gly Thr Gln Leu Glu Arg Gly Ser Ile Thr Leu Trp His Asn 
145                 150                 155                 160 


Leu Asn Tyr Trp Gln Leu Leu Arg Lys Glu Lys Val Pro Val His Lys 
                165                 170                 175     


Val Gly Asn Thr Pro Leu Asp Met Asn Gln Phe Arg Met Leu Phe Ser 
            180                 185                 190         


Thr Cys Lys Val Pro Gly Ile Thr Arg Asp Ser Ile Met Asn Tyr Phe 
        195                 200                 205             


Arg Thr Glu Ser Glu Gly Arg Ser Pro Asn His Ile Val Val Leu Cys 
    210                 215                 220                 


Arg Gly Arg Ala Phe Val Phe Asp Val Ile His Glu Gly Cys Leu Val 
225                 230                 235                 240 


Thr Pro Pro Glu Leu Leu Arg Gln Leu Thr Tyr Ile His Lys Lys Cys 
                245                 250                 255     


His Ser Glu Pro Asp Gly Pro Gly Ile Ala Ala Leu Thr Ser Glu Glu 
            260                 265                 270         


Arg Thr Arg Trp Ala Lys Ala Arg Glu Tyr Leu Ile Gly Leu Asp Pro 
        275                 280                 285             


Glu Asn Leu Ala Leu Leu Glu Lys Ile Gln Ser Ser Leu Leu Val Tyr 
    290                 295                 300                 


Ser Met Glu Asp Ser Ser Pro His Val Thr Pro Glu Asp Tyr Ser Glu 
305                 310                 315                 320 


Ile Ile Ala Ala Ile Leu Ile Gly Asp Pro Thr Val Arg Trp Gly Asp 
                325                 330                 335     


Lys Ser Tyr Asn Leu Ile Ser Phe Ser Asn Gly Val Phe Gly Cys Asn 
            340                 345                 350         


Cys Asp His Ala Pro Phe Asp Ala Met Ile Met Val Asn Ile Ser Tyr 
        355                 360                 365             


Tyr Val Asp Glu Lys Ile Phe Gln Asn Glu Gly Arg Trp Lys Gly Ser 
    370                 375                 380                 


Glu Lys Val Arg Asp Ile Pro Leu Pro Glu Glu Leu Ile Phe Ile Val 
385                 390                 395                 400 


Asp Glu Lys Val Leu Asn Asp Ile Asn Gln Ala Lys Ala Gln Tyr Leu 
                405                 410                 415     


Arg Glu Ala Ser Asp Leu Gln Ile Ala Ala Tyr Ala Phe Thr Ser Phe 
            420                 425                 430         


Gly Lys Lys Leu Thr Lys Asn Lys Met Leu His Pro Asp Thr Phe Ile 
        435                 440                 445             


Gln Leu Ala Leu Gln Leu Ala Tyr Tyr Arg Leu His Gly His Pro Gly 
    450                 455                 460                 


Cys Cys Tyr Glu Thr Ala Met Thr Arg His Phe Tyr His Gly Arg Thr 
465                 470                 475                 480 


Glu Thr Met Arg Ser Cys Thr Val Glu Ala Val Arg Trp Cys Gln Ser 
                485                 490                 495     


Met Gln Asp Pro Ser Val Asn Leu Arg Glu Arg Gln Gln Lys Met Leu 
            500                 505                 510         


Gln Ala Phe Ala Lys His Asn Lys Met Met Lys Asp Cys Ser Ala Gly 
        515                 520                 525             


Lys Gly Phe Asp Arg His Leu Leu Gly Leu Leu Leu Ile Ala Lys Glu 
    530                 535                 540                 


Glu Gly Leu Pro Val Pro Glu Leu Phe Thr Asp Pro Leu Phe Ser Lys 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Asn Phe Val Leu Ser Thr Ser Leu Val Gly Tyr 
                565                 570                 575     


Leu Arg Val Gln Gly Val Val Val Pro Met Val His Asn Gly Tyr Gly 
            580                 585                 590         


Phe Phe Tyr His Ile Arg Asp Asp Arg Phe Val Val Ala Cys Ser Ala 
        595                 600                 605             


Trp Lys Ser Cys Pro Glu Thr Asp Ala Glu Lys Leu Val Gln Leu Thr 
    610                 615                 620                 


Phe Cys Ala Phe His Asp Met Ile Gln Leu Met Asn Ser Thr His Leu 
625                 630                 635                 640 


<210> 7366
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7366
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 7367
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7367
Xaa Thr Arg His Phe Lys Glu Ser Ile Lys Phe Ile His Glu Cys Arg 
1               5                   10                  15      


Leu Arg Gly Glu Ser Cys Leu Val His Cys Leu Ala Gly Val Ser Arg 
            20                  25                  30          


Ser Val Thr Leu Val Ile Ala Tyr Ile Met Thr Val Thr Asp Phe Gly 
        35                  40                  45              


Trp Glu Asp Ala Leu His Thr Val Arg Ala Gly Arg Ser Cys Ala Asn 
    50                  55                  60                  


Pro Asn Val Gly Phe Gln Arg Gln Leu Gln Glu Phe Glu Lys His Glu 
65                  70                  75                  80  


Val His Gln Tyr Arg Gln Trp Leu Lys Glu Glu Tyr Gly Glu Ser Pro 
                85                  90                  95      


Leu Gln Asp Ala Glu Glu Ala Lys Asn Ile Leu Gly Lys Tyr Lys Glu 
            100                 105                 110         


Gln Gly Arg Thr Glu Pro Gln Pro Gly Ala Arg Arg Trp Ser Ser Phe 
        115                 120                 125             


Pro Ala Leu Ala Pro Leu Thr Tyr Asp Asn Tyr Thr Thr Glu Thr 
    130                 135                 140             


<210> 7368
<211> 164
<212> PRT
<213> Homo sapiens

<400> 7368
Met Val Asn Ser Val Ile Phe Phe Asp Ile Thr Val Asp Gly Lys Pro 
1               5                   10                  15      


Leu Gly Arg Ile Ser Ile Lys Gln Phe Ala Asp Lys Ile Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Arg Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr His Pro Asn Gly Thr Gly Asp Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Asp Asp Glu Asn Leu Ile Arg Lys His Thr Gly Ser Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Ala 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Arg Val Asn Ile Val Glu Ala Met Glu His 
    130                 135                 140                 


Phe Gly Tyr Arg Asn Ser Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Phe 
                


<210> 7369
<211> 155
<212> PRT
<213> Homo sapiens

<400> 7369
Met Ser Glu Gly Glu Ser Gln Thr Val Leu Ser Ser Gly Ser Asp Pro 
1               5                   10                  15      


Lys Val Glu Ser Ser Ser Ser Ala Pro Gly Leu Thr Ser Val Ser Pro 
            20                  25                  30          


Pro Val Thr Ser Thr Thr Ser Ala Ala Ser Pro Glu Glu Glu Glu Glu 
        35                  40                  45              


Ser Glu Asp Glu Ser Glu Ile Leu Glu Glu Ser Pro Cys Gly Arg Trp 
    50                  55                  60                  


Gln Lys Arg Arg Glu Glu Val Asn Gln Arg Asn Val Pro Gly Ile Asp 
65                  70                  75                  80  


Ser Ala Tyr Leu Ala Met Asp Thr Glu Glu Gly Val Glu Val Val Trp 
                85                  90                  95      


Asn Glu Val Gln Phe Ser Glu Arg Lys Asn Tyr Lys Leu Gln Glu Glu 
            100                 105                 110         


Lys Val Arg Ala Val Phe Asp Asn Leu Ile Gln Leu Glu His Leu Asn 
        115                 120                 125             


Ile Val Lys Phe His Lys Tyr Trp Ala Asp Ile Lys Glu Asn Lys Ala 
    130                 135                 140                 


Arg Val Ile Phe Ile Thr Glu Tyr Met Ser Ser 
145                 150                 155 


<210> 7370
<211> 278
<212> PRT
<213> Homo sapiens

<400> 7370
Met Trp Pro Phe Pro Ser Arg Ser Leu Phe Pro Pro Pro Thr Gln Ala 
1               5                   10                  15      


Trp Leu Gln Thr Val Ser Ser Asp Pro Glu Ala Gln Gly Trp Gly Ala 
            20                  25                  30          


Trp Asn Glu Thr Lys Glu Ile Leu Gly Pro Glu Gly Gly Glu Gly Lys 
        35                  40                  45              


Glu Glu Lys Glu Glu Glu Glu Asp Ala Glu Glu Asp Gln Asp Gly Asp 
    50                  55                  60                  


Ala Gly Phe Leu Leu Ser Leu Leu Glu Gln Glu Asn Leu Ala Glu Cys 
65                  70                  75                  80  


Pro Leu Pro Asp Gln Glu Leu Glu Ala Ile Lys Met Lys Val Cys Ala 
                85                  90                  95      


Met Glu Gln Ala Glu Gly Thr Pro Arg Pro Pro Gly Val Gln Gln Gln 
            100                 105                 110         


Ala Glu Glu Glu Glu Gly Thr Ala Ala Gly Gln Leu Leu Ser Pro Glu 
        115                 120                 125             


Thr Val Gly Cys Pro Leu Ser Gly Thr Pro Glu Glu Lys Val Glu Ala 
    130                 135                 140                 


Asp His Arg Ser Val Tyr Val Gly Asn Val Asp Tyr Gly Gly Ser Ala 
145                 150                 155                 160 


Glu Glu Leu Glu Ala His Phe Ser Arg Cys Gly Glu Val His Arg Val 
                165                 170                 175     


Thr Ile Leu Cys Asp Lys Phe Ser Gly His Pro Lys Gly Tyr Ala Tyr 
            180                 185                 190         


Ile Glu Phe Ala Thr Lys Gly Ser Val Gln Ala Ala Val Glu Leu Asp 
        195                 200                 205             


Gln Ser Leu Phe Arg Gly Arg Val Ile Lys Val Leu Pro Lys Arg Thr 
    210                 215                 220                 


Asn Phe Pro Gly Ile Ser Ser Thr Asp Arg Gly Gly Leu Arg Gly His 
225                 230                 235                 240 


Pro Gly Ser Arg Gly Ala Pro Phe Pro His Ser Gly Leu Gln Gly Arg 
                245                 250                 255     


Pro Arg Leu Arg Pro Gln Gly Gln Asn Arg Ala Arg Gly Lys Phe Ser 
            260                 265                 270         


Pro Trp Phe Ser Pro Tyr 
        275             


<210> 7371
<211> 43
<212> PRT
<213> Homo sapiens

<400> 7371
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln 
        35                  40              


<210> 7372
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7372
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu 
1               5                   10                  15      


Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala 
            20                  25                  30          


Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu 
        35                  40                  45              


Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro 
    50                  55                  60                  


Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr 
65                  70                  75                  80  


Gly Gln Leu Ser Glu Lys Val Ser Leu Asp Ser Leu Glu Glu Leu Tyr 
                85                  90                  95      


Cys Tyr Leu Leu Tyr Gln Asn Met Ala Ser Lys Gly Gln Leu His Leu 
            100                 105                 110         


His Trp Ile Thr Glu Phe Leu Leu Thr Leu Arg Arg Asn Cys Trp Arg 
        115                 120                 125             


Glu 
    


<210> 7373
<211> 761
<212> PRT
<213> Homo sapiens

<400> 7373
Met Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His 
1               5                   10                  15      


Gly Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu 
            20                  25                  30          


Ala Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp Arg 
        35                  40                  45              


Thr Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln 
    50                  55                  60                  


Arg His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu 
65                  70                  75                  80  


Gly Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu 
                85                  90                  95      


Thr Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr 
            100                 105                 110         


Arg Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe 
        115                 120                 125             


Leu Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile 
    130                 135                 140                 


Gly Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg 
145                 150                 155                 160 


Leu Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro 
                165                 170                 175     


Leu Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg 
            180                 185                 190         


Leu Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val 
        195                 200                 205             


Ala Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys 
    210                 215                 220                 


Arg Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys 
225                 230                 235                 240 


Lys Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn 
                245                 250                 255     


Leu Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser 
            260                 265                 270         


Gly Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly 
        275                 280                 285             


Phe Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu 
    290                 295                 300                 


Asp Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg 
305                 310                 315                 320 


Ala Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly 
                325                 330                 335     


Met Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala 
            340                 345                 350         


Glu Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe 
        355                 360                 365             


Arg Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro 
    370                 375                 380                 


Arg Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr 
                405                 410                 415     


Glu Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly 
            420                 425                 430         


Ala Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser 
        435                 440                 445             


Val Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala 
    450                 455                 460                 


Ala Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr 
465                 470                 475                 480 


Glu Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg 
                485                 490                 495     


Ser Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val 
            500                 505                 510         


Phe Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu 
        515                 520                 525             


Leu Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr 
    530                 535                 540                 


Gln Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val 
545                 550                 555                 560 


Cys Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His 
                565                 570                 575     


Thr Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu 
            580                 585                 590         


Ala Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu 
        595                 600                 605             


Gln Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu 
    610                 615                 620                 


Ser Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu 
                645                 650                 655     


Leu Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser 
            660                 665                 670         


Leu Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg 
        675                 680                 685             


Ser Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn 
    690                 695                 700                 


Ser Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile 
705                 710                 715                 720 


Asn Arg Thr Leu Thr Ser Leu Arg Val Lys Phe Met Tyr His Lys Ile 
                725                 730                 735     


Asp Cys Phe Arg Arg Val Pro Glu Ala Asp Ala Cys Asn Pro Ser Thr 
            740                 745                 750         


Leu Gly Gly Gln Gly Arg Trp Ile Thr 
        755                 760     


<210> 7374
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7374
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 7375
<211> 490
<212> PRT
<213> Homo sapiens

<400> 7375
Met Thr Ile Gly Arg Met Glu Asn Val Glu Val Phe Thr Ala Glu Gly 
1               5                   10                  15      


Lys Gly Arg Gly Leu Lys Ala Thr Lys Glu Phe Trp Ala Ala Asp Ile 
            20                  25                  30          


Ile Phe Ala Glu Arg Ala Tyr Ser Ala Val Val Phe Asp Ser Leu Val 
        35                  40                  45              


Asn Phe Val Cys His Thr Cys Phe Lys Arg Gln Glu Lys Leu His Arg 
    50                  55                  60                  


Cys Gly Gln Cys Lys Phe Ala His Tyr Cys Asp Arg Thr Cys Gln Lys 
65                  70                  75                  80  


Asp Ala Trp Leu Asn His Lys Asn Glu Cys Ser Ala Ile Lys Arg Tyr 
                85                  90                  95      


Gly Lys Val Pro Asn Glu Asn Ile Arg Leu Ala Ala Arg Ile Met Trp 
            100                 105                 110         


Arg Val Glu Arg Glu Gly Thr Gly Leu Thr Glu Gly Cys Leu Val Ser 
        115                 120                 125             


Val Asp Asp Leu Gln Asn His Val Glu His Phe Gly Glu Glu Glu Gln 
    130                 135                 140                 


Lys Asp Leu Arg Val Asp Val Asp Thr Phe Leu Gln Tyr Trp Pro Pro 
145                 150                 155                 160 


Gln Ser Gln Gln Phe Ser Met Gln Tyr Ile Ser His Ile Phe Gly Val 
                165                 170                 175     


Ile Asn Cys Asn Gly Phe Thr Leu Ser Asp Gln Arg Gly Leu Gln Ala 
            180                 185                 190         


Val Gly Val Gly Ile Phe Pro Asn Leu Gly Leu Val Asn His Asp Cys 
        195                 200                 205             


Trp Pro Asn Cys Thr Val Ile Phe Asn Asn Gly Asn His Glu Ala Val 
    210                 215                 220                 


Lys Ser Met Phe His Thr Gln Met Arg Ile Glu Leu Arg Ala Leu Gly 
225                 230                 235                 240 


Lys Ile Ser Glu Gly Glu Glu Leu Thr Val Ser Tyr Ile Asp Phe Leu 
                245                 250                 255     


Asn Val Ser Glu Glu Arg Lys Arg Gln Leu Lys Lys Gln Tyr Tyr Phe 
            260                 265                 270         


Asp Cys Thr Cys Glu His Cys Gln Lys Lys Leu Lys Asp Asp Leu Phe 
        275                 280                 285             


Leu Gly Val Lys Asp Asn Pro Lys Pro Ser Gln Glu Val Val Lys Glu 
    290                 295                 300                 


Met Ile Gln Phe Ser Lys Asp Thr Leu Glu Lys Ile Asp Lys Ala Arg 
305                 310                 315                 320 


Ser Glu Gly Leu Tyr His Glu Val Val Lys Leu Cys Arg Glu Cys Leu 
                325                 330                 335     


Glu Lys Gln Glu Pro Val Phe Ala Asp Thr Asn Ile Tyr Met Leu Arg 
            340                 345                 350         


Met Leu Ser Ile Val Ser Glu Val Leu Ser Tyr Leu Gln Ala Phe Glu 
        355                 360                 365             


Glu Ala Ser Phe Tyr Ala Arg Arg Met Val Asp Gly Tyr Met Lys Leu 
    370                 375                 380                 


Tyr His Pro Asn Asn Ala Gln Leu Gly Met Ala Val Met Arg Ala Gly 
385                 390                 395                 400 


Leu Thr Asn Trp His Ala Gly Asn Ile Glu Val Gly His Gly Met Ile 
                405                 410                 415     


Cys Lys Ala Tyr Ala Ile Leu Leu Val Thr His Gly Pro Ser His Pro 
            420                 425                 430         


Ile Thr Lys Asp Leu Glu Ala Met Arg Val Gln Thr Glu Met Glu Leu 
        435                 440                 445             


Arg Met Phe Arg Gln Asn Glu Phe Met Tyr Tyr Lys Met Arg Glu Ala 
    450                 455                 460                 


Ala Leu Asn Asn Gln Pro Met Gln Val Met Ala Glu Pro Ser Asn Glu 
465                 470                 475                 480 


Pro Ser Pro Ala Leu Phe His Lys Lys Gln 
                485                 490 


<210> 7376
<211> 496
<212> PRT
<213> Homo sapiens

<400> 7376
Met Trp Gly Arg Phe Leu Ala Pro Glu Ala Ser Gly Arg Asp Ser Pro 
1               5                   10                  15      


Gly Gly Ala Arg Ser Phe Pro Ala Gly Pro Asp Tyr Ser Ser Ala Trp 
            20                  25                  30          


Leu Pro Ala Asn Glu Ser Leu Trp Gln Ala Thr Thr Val Pro Ser Asn 
        35                  40                  45              


His Arg Asn Asn His Ile Arg Arg His Ser Ile Ala Ser Asp Ser Gly 
    50                  55                  60                  


Asp Thr Gly Ile Gly Thr Ser Cys Ser Asp Ser Val Glu Asp His Ser 
65                  70                  75                  80  


Thr Ser Ser Gly Thr Leu Ser Phe Lys Pro Ser Gln Ser Leu Ile Thr 
                85                  90                  95      


Leu Pro Thr Ala His Val Met Pro Ser Asn Ser Ser Ala Ser Ile Ser 
            100                 105                 110         


Lys Leu Arg Glu Ser Leu Thr Pro Asp Gly Ser Lys Trp Ser Thr Ser 
        115                 120                 125             


Leu Met Gln Thr Leu Gly Asn His Ser Arg Gly Glu Gln Asp Ser Ser 
    130                 135                 140                 


Leu Asp Met Lys Asp Phe Arg Pro Leu Arg Lys Trp Ser Ser Leu Ser 
145                 150                 155                 160 


Lys Leu Thr Ala Pro Asp Asn Cys Gly Gln Gly Gly Thr Val Cys Arg 
                165                 170                 175     


Glu Glu Ser Arg Asn Gly Leu Glu Lys Ile Gly Lys Ala Lys Ala Leu 
            180                 185                 190         


Thr Ser Gln Leu Arg Thr Ile Gly Pro Ser Cys Leu His Asp Ser Met 
        195                 200                 205             


Glu Met Leu Arg Leu Glu Asp Lys Glu Ile Asn Lys Lys Arg Ser Ser 
    210                 215                 220                 


Thr Leu Asp Cys Lys Tyr Lys Phe Glu Ser Cys Ser Lys Glu Asp Phe 
225                 230                 235                 240 


Arg Ala Ser Ser Ser Thr Leu Arg Arg Gln Pro Val Asp Met Thr Tyr 
                245                 250                 255     


Ser Ala Leu Pro Glu Ser Lys Pro Ile Met Thr Ser Ser Glu Ala Phe 
            260                 265                 270         


Glu Pro Pro Lys Tyr Leu Met Leu Gly Gln Gln Ala Val Gly Gly Val 
        275                 280                 285             


Pro Ile Gln Pro Ser Val Arg Thr Gln Met Trp Leu Thr Glu Gln Leu 
    290                 295                 300                 


Arg Thr Asn Pro Leu Glu Gly Arg Asn Thr Glu Asp Ser Tyr Ser Leu 
305                 310                 315                 320 


Ala Pro Trp Gln Gln Gln Gln Ile Glu Asp Phe Arg Gln Gly Ser Glu 
                325                 330                 335     


Thr Pro Met Gln Val Leu Thr Gly Ser Ser Arg Gln Ser Tyr Ser Pro 
            340                 345                 350         


Gly Tyr Gln Asp Phe Ser Lys Trp Glu Ser Met Leu Lys Ile Lys Glu 
        355                 360                 365             


Gly Leu Leu Arg Gln Lys Glu Ile Val Ile Asp Arg Gln Lys Gln Gln 
    370                 375                 380                 


Ile Thr His Leu His Glu Arg Ile Arg Asp Asn Glu Leu Arg Ala Gln 
385                 390                 395                 400 


His Ala Met Leu Gly His Tyr Val Asn Cys Glu Asp Ser Tyr Val Ala 
                405                 410                 415     


Ser Leu Gln Pro Gln Tyr Glu Asn Thr Ser Leu Gln Thr Pro Phe Ser 
            420                 425                 430         


Glu Glu Ser Val Ser His Ser Gln Gln Gly Glu Phe Glu Gln Lys Leu 
        435                 440                 445             


Ala Ser Thr Glu Lys Glu Val Leu Gln Leu Asn Glu Phe Leu Lys Gln 
    450                 455                 460                 


Arg Leu Ser Leu Phe Ser Glu Glu Lys Lys Lys Leu Glu Glu Lys Val 
465                 470                 475                 480 


Gly Phe Ser Asn Lys Val Glu Leu Gly Gln Gln His Phe Leu Ser Ile 
                485                 490                 495     


<210> 7377
<211> 360
<212> PRT
<213> Homo sapiens

<400> 7377
Met Ala Glu Leu Gln Gln Leu Gln Glu Phe Glu Ile Pro Thr Gly Arg 
1               5                   10                  15      


Glu Ala Leu Arg Gly Asn His Ser Ala Leu Leu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asp Asn Tyr Val Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Met Ala Phe Thr Thr Gln Ala Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Val Gly Asn Leu Ala Gly His Thr Leu Arg Met Leu Asp Leu Gln Gly 
65                  70                  75                  80  


Ala Ala Leu Arg Gln Val Glu Ala Arg Met Val Asn Met His Met Glu 
                85                  90                  95      


Lys Val Ala Arg Arg Glu Ile Gly Thr Leu Ala Thr Val Gln Arg Leu 
            100                 105                 110         


Pro Pro Gly Gln Lys Val Ile Ala Pro Glu Asn Leu Pro Pro Leu Thr 
        115                 120                 125             


Pro Tyr Cys Arg Arg Pro Leu Asn Phe Gly Cys Leu Asp Asp Ile Gly 
    130                 135                 140                 


His Gly Ile Lys Asp Leu Ser Thr Gln Leu Ser Arg Thr Gly Thr Leu 
145                 150                 155                 160 


Ser Arg Lys Ser Ile Lys Ala Pro Ala Thr Pro Ala Ser Ala Thr Leu 
                165                 170                 175     


Gly Arg Pro Pro Arg Ile Pro Glu Pro Val His Leu Pro Val Val Pro 
            180                 185                 190         


Asp Gly Arg Leu Ser Ala Ala Ser Ser Ala Phe Ser Leu Ala Ser Ala 
        195                 200                 205             


Gly Ser Ala Glu Gly Val Gly Gly Ala Pro Thr Pro Lys Gly Gln Ala 
    210                 215                 220                 


Ala Pro Pro Ala Pro Pro Leu Pro Ser Ser Leu Asp Pro Pro Pro Pro 
225                 230                 235                 240 


Pro Ala Ala Val Glu Val Phe Gln Arg Pro Pro Thr Leu Glu Glu Leu 
                245                 250                 255     


Ser Pro Pro Pro Pro Asp Glu Glu Leu Pro Leu Pro Leu Asp Leu Pro 
            260                 265                 270         


Pro Pro Pro Pro Leu Asp Gly Asp Glu Leu Gly Leu Pro Pro Pro Pro 
        275                 280                 285             


Pro Gly Phe Gly Pro Asp Glu Pro Ser Trp Val Pro Ala Ser Tyr Leu 
    290                 295                 300                 


Glu Lys Val Val Thr Leu Tyr Pro Tyr Thr Ser Gln Lys Asp Asn Glu 
305                 310                 315                 320 


Leu Ser Phe Ser Glu Gly Thr Val Ile Cys Val Thr Arg Arg Tyr Ser 
                325                 330                 335     


Asp Gly Trp Cys Glu Gly Val Ser Ser Glu Gly Thr Gly Phe Phe Pro 
            340                 345                 350         


Gly Asn Tyr Val Glu Pro Ser Cys 
        355                 360 


<210> 7378
<211> 66
<212> PRT
<213> Homo sapiens

<400> 7378
Met Leu Arg Cys Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg 
1               5                   10                  15      


His Leu Gly Arg Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp 
            20                  25                  30          


Ser Tyr Phe Ser Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr 
        35                  40                  45              


Tyr Ser Ile His Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser 
    50                  55                  60                  


Ile Gly 
65      


<210> 7379
<211> 491
<212> PRT
<213> Homo sapiens

<400> 7379
Met Glu Gln Pro Pro Ala Pro Lys Ser Lys Leu Lys Lys Leu Ser Glu 
1               5                   10                  15      


Asp Ser Leu Thr Lys Gln Pro Glu Glu Val Phe Asp Val Leu Glu Lys 
            20                  25                  30          


Leu Gly Glu Gly Ser Tyr Gly Ser Val Phe Lys Ala Ile His Lys Glu 
        35                  40                  45              


Ser Gly Gln Val Val Ala Ile Lys Gln Val Pro Val Glu Ser Asp Leu 
    50                  55                  60                  


Gln Glu Ile Ile Lys Glu Ile Ser Ile Met Gln Gln Cys Asp Ser Pro 
65                  70                  75                  80  


Tyr Val Val Lys Tyr Tyr Gly Ser Tyr Phe Lys Asn Thr Asp Leu Trp 
                85                  90                  95      


Ile Val Met Glu Tyr Cys Gly Ala Gly Ser Val Ser Asp Ile Ile Arg 
            100                 105                 110         


Leu Arg Asn Lys Thr Leu Ile Glu Asp Glu Ile Ala Thr Ile Leu Lys 
        115                 120                 125             


Ser Thr Leu Lys Gly Leu Glu Tyr Leu His Phe Met Arg Lys Ile His 
    130                 135                 140                 


Arg Asp Ile Lys Ala Gly Asn Ile Leu Leu Asn Thr Glu Gly His Ala 
145                 150                 155                 160 


Lys Leu Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Met Ala 
                165                 170                 175     


Lys Arg Asn Thr Val Ile Gly Thr Pro Phe Trp Met Ala Pro Glu Val 
            180                 185                 190         


Ile Gln Glu Ile Gly Tyr Asn Cys Val Ala Asp Ile Trp Ser Leu Gly 
        195                 200                 205             


Ile Thr Ser Ile Glu Met Ala Glu Gly Lys Pro Pro Tyr Ala Asp Ile 
    210                 215                 220                 


His Pro Met Arg Ala Ile Phe Met Ile Pro Thr Asn Pro Pro Pro Thr 
225                 230                 235                 240 


Phe Arg Lys Pro Glu Leu Trp Ser Asp Asp Phe Thr Asp Phe Val Lys 
                245                 250                 255     


Lys Cys Leu Val Lys Asn Pro Glu Gln Arg Ala Thr Ala Thr Gln Leu 
            260                 265                 270         


Leu Gln His Pro Phe Ile Lys Asn Ala Lys Pro Val Ser Ile Leu Arg 
        275                 280                 285             


Asp Leu Ile Thr Glu Ala Met Glu Ile Lys Ala Lys Arg His Glu Glu 
    290                 295                 300                 


Gln Gln Arg Glu Leu Glu Glu Glu Glu Glu Asn Ser Asp Glu Asp Glu 
305                 310                 315                 320 


Leu Asp Ser His Thr Met Val Lys Thr Ser Val Glu Ser Val Gly Thr 
                325                 330                 335     


Met Arg Ala Thr Ser Thr Met Ser Glu Gly Ala Gln Thr Met Ile Glu 
            340                 345                 350         


His Asn Ser Thr Met Leu Glu Ser Asp Leu Gly Thr Met Val Ile Asn 
        355                 360                 365             


Ser Glu Asp Glu Glu Glu Glu Asp Gly Thr Met Lys Arg Asn Ala Thr 
    370                 375                 380                 


Ser Pro Gln Val Gln Arg Pro Ser Phe Met Asp Tyr Phe Asp Lys Gln 
385                 390                 395                 400 


Asp Phe Lys Asn Lys Ser His Glu Asn Cys Asn Gln Asn Met His Glu 
                405                 410                 415     


Pro Phe Pro Met Ser Lys Asn Val Phe Pro Asp Asn Trp Lys Val Pro 
            420                 425                 430         


Gln Asp Gly Asp Phe Asp Phe Leu Lys Asn Leu Ser Leu Glu Glu Leu 
        435                 440                 445             


Gln Met Arg Leu Lys Ala Leu Asp Pro Met Met Glu Arg Glu Ile Glu 
    450                 455                 460                 


Glu Leu Arg Gln Arg Tyr Thr Ala Lys Arg Gln Pro Ile Leu Asp Ala 
465                 470                 475                 480 


Met Asp Ala Lys Lys Arg Arg Gln Gln Asn Phe 
                485                 490     


<210> 7380
<211> 41
<212> PRT
<213> Homo sapiens

<400> 7380
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val 
        35                  40      


<210> 7381
<211> 314
<212> PRT
<213> Homo sapiens

<400> 7381
Met Pro Asn Val Ala Glu Thr Glu Arg Ser Asn Asp Ser Gly Asn Gly 
1               5                   10                  15      


Glu His Lys Ser Glu Arg Lys Ser Pro Glu Glu Asn Leu Gln Gly Ala 
            20                  25                  30          


Val Lys Ser Phe Cys Thr Ser Ala Ser Gly Ala Pro Leu Gly Pro Lys 
        35                  40                  45              


Gly Asp Gly His Tyr Pro Trp Ser Cys Pro Val Thr His Thr Arg Glu 
    50                  55                  60                  


Lys Ile Tyr Ala Ile Cys Ser Asp Tyr Ala Phe Leu Asn Gln Ala Thr 
65                  70                  75                  80  


Ser Ile Tyr Lys Thr Pro Asn Pro Ser Arg Ser Pro Cys Leu Pro Asp 
                85                  90                  95      


Ser Thr Ser Leu Ser Ala Gly Asn Asn Ser Ser Arg Tyr Ile Gly Ile 
            100                 105                 110         


Pro Thr Ser Thr Ser Glu Ile Ile Tyr Asn Glu Glu Asn Ser Leu Glu 
        115                 120                 125             


Asn Leu Ser Asn Ser Leu Gly Lys Leu Pro Leu Ala Trp Glu Ile Asp 
    130                 135                 140                 


Lys Ser Glu Phe Asp Gly Val Thr Thr Asn Ser Lys His Lys Ser Gly 
145                 150                 155                 160 


Asn Ala Lys Lys Gln Val Ser Lys Arg Lys Thr Ser Asp Lys Lys Gly 
                165                 170                 175     


Arg Tyr Gln Lys Glu Cys Pro Gln His Ser Pro Leu Glu Asp Ile Lys 
            180                 185                 190         


Gln Arg Lys Val Leu Asp Leu Arg Arg Trp Tyr Cys Ile Ser Arg Pro 
        195                 200                 205             


Gln Tyr Lys Thr Ser Cys Gly Ile Ser Ser Leu Ile Ser Cys Trp Asn 
    210                 215                 220                 


Phe Leu Tyr Ser Thr Met Gly Ala Gly Asn Leu Pro Pro Ile Thr Gln 
225                 230                 235                 240 


Glu Glu Ala Leu His Ile Leu Gly Phe Gln Pro Pro Phe Glu Asp Ile 
                245                 250                 255     


Arg Phe Gly Pro Phe Thr Gly Asn Thr Thr Leu Met Arg Trp Phe Arg 
            260                 265                 270         


Gln Ile Asn Asp His Phe His Val Lys Gly Cys Ser Tyr Val Leu Tyr 
        275                 280                 285             


Lys Pro His Gly Lys Asn Lys Thr Ala Gly Glu Thr Ala Gly Asp Leu 
    290                 295                 300                 


Ser His His Arg Lys Leu Asn Ile Gly Ser 
305                 310                 


<210> 7382
<211> 499
<212> PRT
<213> Homo sapiens

<400> 7382
Met Pro Glu Ile Arg Val Thr Pro Leu Gly Ala Gly Gln Asp Val Gly 
1               5                   10                  15      


Arg Ser Cys Ile Leu Val Ser Ile Ala Gly Lys Asn Val Met Leu Asp 
            20                  25                  30          


Cys Gly Met His Met Gly Phe Asn Asp Asp Val Asp Asp Glu Leu Glu 
        35                  40                  45              


Ile Lys Ala Tyr Tyr Ala Gly His Val Leu Gly Ala Ala Met Phe Gln 
    50                  55                  60                  


Ile Lys Val Gly Ser Glu Ser Val Val Tyr Thr Gly Asp Tyr Asn Met 
65                  70                  75                  80  


Thr Pro Asp Arg His Leu Gly Ala Ala Trp Ile Asp Lys Cys Arg Pro 
                85                  90                  95      


Asn Leu Leu Ile Thr Glu Ser Thr Tyr Ala Thr Thr Ile Arg Asp Ser 
            100                 105                 110         


Lys Arg Cys Arg Glu Arg Asp Phe Leu Lys Lys Val His Glu Thr Val 
        115                 120                 125             


Glu Arg Gly Gly Lys Val Leu Ile Pro Val Phe Ala Leu Gly Arg Ala 
    130                 135                 140                 


Gln Glu Leu Cys Ile Leu Leu Glu Thr Phe Trp Glu Arg Met Asn Leu 
145                 150                 155                 160 


Lys Val Pro Ile Tyr Phe Ser Thr Gly Leu Thr Glu Lys Ala Asn His 
                165                 170                 175     


Tyr Tyr Lys Leu Phe Ile Pro Trp Thr Asn Gln Lys Ile Arg Lys Thr 
            180                 185                 190         


Phe Val Gln Arg Asn Met Phe Glu Phe Lys His Ile Lys Ala Phe Asp 
        195                 200                 205             


Arg Ala Phe Ala Asp Asn Pro Gly Pro Met Val Val Phe Ala Thr Pro 
    210                 215                 220                 


Gly Met Leu His Ala Gly Gln Ser Leu Gln Ile Phe Arg Lys Trp Ala 
225                 230                 235                 240 


Gly Asn Glu Lys Asn Met Val Ile Met Pro Gly Tyr Cys Val Gln Gly 
                245                 250                 255     


Thr Val Gly His Lys Ile Leu Ser Gly Gln Arg Lys Leu Glu Met Glu 
            260                 265                 270         


Gly Arg Gln Val Leu Glu Val Lys Met Gln Val Glu Tyr Met Ser Phe 
        275                 280                 285             


Ser Ala His Ala Asp Ala Lys Gly Ile Met Gln Leu Val Gly Gln Ala 
    290                 295                 300                 


Glu Pro Glu Ser Val Leu Leu Val His Gly Glu Ala Lys Lys Met Glu 
305                 310                 315                 320 


Phe Leu Lys Gln Lys Ile Glu Gln Glu Leu Arg Val Asn Cys Tyr Met 
                325                 330                 335     


Pro Ala Asn Gly Glu Thr Val Thr Leu Pro Thr Ser Pro Ser Ile Pro 
            340                 345                 350         


Val Gly Ile Ser Leu Gly Leu Leu Lys Arg Glu Met Ala Gln Gly Leu 
        355                 360                 365             


Leu Pro Glu Ala Lys Lys Pro Arg Leu Leu His Gly Thr Leu Ile Met 
    370                 375                 380                 


Lys Asp Ser Asn Phe Arg Leu Val Ser Ser Glu Gln Ala Leu Lys Glu 
385                 390                 395                 400 


Leu Gly Leu Ala Glu His Gln Leu Arg Phe Thr Cys Arg Val His Leu 
                405                 410                 415     


His Asp Thr Arg Lys Glu Gln Glu Thr Ala Leu Arg Val Tyr Ser His 
            420                 425                 430         


Leu Lys Ser Val Leu Lys Asp His Cys Val Gln His Leu Pro Asp Gly 
        435                 440                 445             


Ser Val Thr Val Glu Ser Val Leu Leu Gln Ala Ala Ala Pro Ser Glu 
    450                 455                 460                 


Asp Pro Gly Thr Lys Val Leu Leu Val Ser Trp Thr Tyr Gln Asp Glu 
465                 470                 475                 480 


Glu Leu Gly Ser Phe Leu Thr Ser Leu Leu Lys Lys Gly Leu Pro Gln 
                485                 490                 495     


Ala Pro Ser 
            


<210> 7383
<211> 131
<212> PRT
<213> Homo sapiens

<400> 7383
Gly Thr Ile Ser Cys Ser Thr Gly Thr Leu Gln Arg Arg Asn Leu Gly 
1               5                   10                  15      


Pro Glu Arg Gln Thr Gly Leu Leu Leu Leu Gly Met Lys Glu Asn Gln 
            20                  25                  30          


Glu Leu Lys Thr Ile Gln Ala Asn Leu Ser Arg Gln Arg Val Glu His 
        35                  40                  45              


Gln Cys Leu Ser Ser Glu Glu Leu Lys Gln Arg Phe Pro Asn Ile Arg 
    50                  55                  60                  


Leu Pro Arg Gly Glu Val Gly Leu Leu Asp Asn Ser Gly Gly Val Ile 
65                  70                  75                  80  


Tyr Ala Tyr Lys Ala Leu Arg Ala Leu Gln Asp Ala Ile Arg Gln Leu 
                85                  90                  95      


Gly Gly Ile Val Arg Asp Gly Glu Lys Val Val Glu Ile Asn Pro Gly 
            100                 105                 110         


Leu Leu Val Thr Val Lys Thr Thr Ser Arg Ser Tyr Gln Ala Lys Ser 
        115                 120                 125             


Leu Val Ile 
    130     


<210> 7384
<211> 228
<212> PRT
<213> Homo sapiens

<400> 7384
Met Ser Arg Glu Arg Gly Ser Arg Ser Glu Glu Pro Gly Ala Gly Asn 
1               5                   10                  15      


Arg Glu Ser Gly Ser Arg Glu Pro Gly Leu Ala Ala Ala Ala Met Ser 
            20                  25                  30          


Thr Val Asp Leu Ala Arg Val Gly Ala Cys Ile Leu Lys His Ala Val 
        35                  40                  45              


Thr Gly Glu Ala Val Glu Leu Arg Ser Leu Trp Arg Glu His Ala Cys 
    50                  55                  60                  


Val Val Ala Gly Leu Arg Arg Phe Gly Cys Val Val Cys Arg Trp Ile 
65                  70                  75                  80  


Ala Gln Asp Leu Ser Ser Leu Ala Gly Leu Leu Asp Gln His Gly Val 
                85                  90                  95      


Arg Leu Val Gly Val Gly Pro Glu Ala Leu Gly Leu Gln Glu Phe Leu 
            100                 105                 110         


Asp Gly Asp Tyr Phe Ala Gly Glu Leu Tyr Leu Asp Glu Ser Lys Gln 
        115                 120                 125             


Leu Tyr Lys Glu Leu Gly Phe Lys Arg Tyr Asn Ser Leu Ser Ile Leu 
    130                 135                 140                 


Pro Ala Ala Leu Gly Lys Pro Val Arg Asp Val Ala Ala Lys Ala Lys 
145                 150                 155                 160 


Ala Val Gly Ile Gln Gly Asn Leu Ser Gly Asp Leu Leu Gln Ser Gly 
                165                 170                 175     


Gly Leu Leu Val Val Ser Lys Gly Gly Asp Lys Val Leu Leu His Phe 
            180                 185                 190         


Val Gln Lys Ser Pro Gly Asp Tyr Val Pro Lys Glu His Ile Leu Gln 
        195                 200                 205             


Val Leu Gly Ile Ser Ala Glu Val Cys Ala Ser Asp Pro Pro Gln Cys 
    210                 215                 220                 


Asp Arg Glu Val 
225             


<210> 7385
<211> 217
<212> PRT
<213> Homo sapiens

<400> 7385
Met Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe 
1               5                   10                  15      


Ser Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val 
            20                  25                  30          


Val Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu 
        35                  40                  45              


Asp Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu 
    50                  55                  60                  


Cys Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln 
65                  70                  75                  80  


Pro Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala 
                85                  90                  95      


Ser Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe 
            100                 105                 110         


His Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr 
        115                 120                 125             


Ile Lys Tyr Pro Lys Ala Cys Leu Gln Gly Ile Thr Phe Thr Arg Asp 
    130                 135                 140                 


Gly Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val 
145                 150                 155                 160 


Ser Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg Tyr Lys Ile Leu 
                165                 170                 175     


Leu Tyr Ser Leu Asp Gly Arg Leu Leu Ser Thr Tyr Ser Ala Tyr Glu 
            180                 185                 190         


Trp Ser Leu Gly Ile Lys Ser Val Ala Trp Ser Pro Ser Ser Gln Phe 
        195                 200                 205             


Leu Ala Val Gly Ser Tyr Asp Gly Lys 
    210                 215         


<210> 7386
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7386
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7387
<211> 316
<212> PRT
<213> Homo sapiens

<400> 7387
Met Glu Glu Asn Asn Leu Gln Cys Ser Ser Val Val Asp Gly Asn Phe 
1               5                   10                  15      


Glu Glu Val Pro Arg Glu Thr Ala Ile Gln Phe Lys Pro Pro Leu Tyr 
            20                  25                  30          


Arg Gln Arg Tyr Gln Phe Val Lys Asn Leu Val Asp Gln His Glu Pro 
        35                  40                  45              


Lys Lys Val Ala Asp Leu Gly Cys Gly Asp Thr Ser Leu Leu Arg Leu 
    50                  55                  60                  


Leu Lys Val Asn Pro Cys Ile Glu Leu Leu Val Gly Val Asp Ile Asn 
65                  70                  75                  80  


Glu Asp Lys Leu Arg Trp Arg Gly Asp Ser Leu Ala Pro Phe Leu Gly 
                85                  90                  95      


Asp Phe Leu Lys Pro Arg Asp Leu Asn Leu Thr Ile Thr Leu Tyr His 
            100                 105                 110         


Gly Ser Val Val Glu Arg Asp Ser Arg Leu Leu Gly Phe Asp Leu Ile 
        115                 120                 125             


Thr Cys Ile Glu Leu Ile Glu His Leu Asp Ser Gly Asp Leu Ala Arg 
    130                 135                 140                 


Phe Pro Glu Val Val Phe Gly Tyr Leu Ser Pro Ser Met Ile Val Ile 
145                 150                 155                 160 


Ser Thr Pro Asn Ser Glu Phe Asn Pro Leu Phe Pro Ser Val Thr Leu 
                165                 170                 175     


Arg Asp Ser Asp His Lys Phe Glu Trp Thr Arg Met Glu Phe Gln Thr 
            180                 185                 190         


Trp Ala Leu Tyr Val Ala Asn Arg Tyr Asp Tyr Ser Val Glu Phe Thr 
        195                 200                 205             


Gly Val Gly Glu Pro Pro Ala Gly Ala Glu Asn Val Gly Tyr Cys Thr 
    210                 215                 220                 


Gln Ile Gly Ile Phe Arg Lys Asn Gly Gly Lys Ala Thr Glu Ser Cys 
225                 230                 235                 240 


Leu Ser Glu Gln His Asp Gln His Val Tyr Lys Ala Val Phe Thr Thr 
                245                 250                 255     


Ser Tyr Pro Ser Leu Gln Gln Glu Arg Phe Phe Lys Leu Val Leu Val 
            260                 265                 270         


Asn Glu Val Ser Gln Gln Val Glu Ser Leu Arg Val Ser His Leu Pro 
        275                 280                 285             


Arg Arg Lys Glu Gln Ala Gly Glu Arg Gly Asp Lys Pro Lys Asp Ile 
    290                 295                 300                 


Gly Gly Ser Lys Ala Pro Val Pro Cys Phe Gly Pro 
305                 310                 315     


<210> 7388
<211> 351
<212> PRT
<213> Homo sapiens

<400> 7388
Met Trp Thr Pro Arg Pro Ala Leu His Val His Val Ile Leu Tyr Ser 
1               5                   10                  15      


Pro Ile His Arg Cys Tyr Ala Arg Ala Asp Pro Thr Met Gly Arg Ile 
            20                  25                  30          


Trp Val Asp Ala Ala Val Pro Cys Leu Glu Glu Cys Gly Phe Leu Leu 
        35                  40                  45              


His Phe Arg Asp Gly Cys Tyr His Leu Glu Thr Ser Thr His His Phe 
    50                  55                  60                  


Leu Ser His Val Asp Arg Leu Phe Ser Gln Pro Ser Ser Gln Thr Ala 
65                  70                  75                  80  


Phe His Met Gln Val Arg Pro Gly Gly Leu Val Ala Leu Cys Asp Gly 
                85                  90                  95      


Glu Gly Gly Met Leu Tyr Pro Gln Gly Thr His Leu Leu Leu Gly Met 
            100                 105                 110         


Gly Cys Asn Pro Met Arg Gly Glu Glu Trp Phe Ile Leu Gln His Cys 
        115                 120                 125             


Pro Thr Trp Val Ser Leu Arg Ser Lys Thr Gly Arg Phe Ile Ser Val 
    130                 135                 140                 


Ile Tyr Asp Gly Glu Val Arg Ala Ala Ser Glu Arg Leu Asn Arg Met 
145                 150                 155                 160 


Ser Leu Phe Gln Phe Glu Cys Asp Ser Glu Ser Pro Thr Val Gln Leu 
                165                 170                 175     


Arg Ser Ala Asn Gly Tyr Tyr Leu Ser Gln Arg Arg His Arg Ala Val 
            180                 185                 190         


Met Ala Asp Gly His Pro Leu Glu Ser Asp Thr Phe Phe Arg Met His 
        195                 200                 205             


Trp Asn Cys Gly Arg Ile Ile Leu Gln Ser Cys Arg Gly Arg Phe Leu 
    210                 215                 220                 


Gly Ile Ala Pro Asn Ser Leu Leu Met Ala Asn Val Ile Leu Pro Gly 
225                 230                 235                 240 


Pro Asn Glu Glu Phe Gly Ile Leu Phe Ala Asn Arg Ser Phe Leu Val 
                245                 250                 255     


Leu Arg Gly Arg Tyr Gly Tyr Val Gly Ser Ser Ser Gly His Asp Leu 
            260                 265                 270         


Ile Gln Cys Asn Gln Asp Gln Pro Asp Arg Ile His Leu Leu Pro Cys 
        275                 280                 285             


Arg Pro Gly Ile Tyr His Phe Gln Gly Gly Ile Leu Leu Val Asn Asn 
    290                 295                 300                 


Ile Leu Trp His Leu Ser Pro Leu Gly Gln Val Cys Pro Gln Leu Leu 
305                 310                 315                 320 


Tyr Arg Ala Ser Gly Glu Gln Leu Thr His Cys Thr Gly Pro Gln Trp 
                325                 330                 335     


Leu Leu His Ala Ser Arg Pro Lys Trp His Pro Val Gly Arg Gln 
            340                 345                 350     


<210> 7389
<211> 110
<212> PRT
<213> Homo sapiens

<400> 7389
Met Gln Ile Ser Ser Glu Lys Glu Glu Asp Asp Asn Glu Lys Arg Gln 
1               5                   10                  15      


Asp Pro Gly Asp Asn Trp Glu Glu Gly Gly Gly Gly Gly Gly Gly Met 
            20                  25                  30          


Glu Lys Ser Ser Gly Pro Trp Asn Lys Thr Ala Pro Val Gln Ala Pro 
        35                  40                  45              


Pro Ala Pro Val Ile Val Thr Glu Thr Pro Glu Pro Ala Met Thr Ser 
    50                  55                  60                  


Gly Val Tyr Arg Pro Pro Gly Ala Arg Leu Thr Thr Thr Arg Lys Thr 
65                  70                  75                  80  


Pro Gln Gly Pro Pro Glu Ile Tyr Ser Asp Thr Gln Phe Pro Ser Leu 
                85                  90                  95      


Gln Ser Thr Ala Lys His Val Glu Ser Arg Lys Tyr Leu Lys 
            100                 105                 110 


<210> 7390
<211> 323
<212> PRT
<213> Homo sapiens

<400> 7390
Met Glu Gly His Asp Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu Phe 
1               5                   10                  15      


Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Asp Ser Leu Arg Glu His 
            20                  25                  30          


Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp Pro 
        35                  40                  45              


Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ser Cys Val 
    50                  55                  60                  


Glu Glu Val Asp Ala Ala Met Cys Ala Arg Pro His Lys Val Asp Gly 
65                  70                  75                  80  


Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Val Lys 
                85                  90                  95      


Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys 
            100                 105                 110         


Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp Tyr Phe Glu Lys Tyr Gly 
        115                 120                 125             


Lys Ile Glu Thr Ile Glu Val Met Glu Asp Arg Gln Ser Gly Lys Lys 
    130                 135                 140                 


Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Thr Val Asp Lys 
145                 150                 155                 160 


Ile Val Val Gln Lys Tyr His Thr Ile Asn Gly His Asn Cys Glu Val 
                165                 170                 175     


Lys Lys Ala Leu Ser Lys Gln Glu Met Gln Ser Ala Gly Ser Gln Arg 
            180                 185                 190         


Gly Arg Gly Gly Gly Ser Gly Asn Phe Met Gly Arg Gly Gly Asn Phe 
        195                 200                 205             


Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly Gly Gly Asn Tyr Gly Gly 
    210                 215                 220                 


Gly Pro Gly Tyr Ser Ser Arg Gly Gly Tyr Gly Gly Gly Gly Pro Gly 
225                 230                 235                 240 


Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Gly Gly Tyr Asp Gly 
                245                 250                 255     


Tyr Asn Glu Gly Gly Asn Phe Gly Gly Gly Asn Tyr Gly Gly Gly Gly 
            260                 265                 270         


Asn Tyr Asn Asp Phe Gly Asn Tyr Ser Gly Gln Gln Gln Ser Asn Tyr 
        275                 280                 285             


Gly Pro Met Lys Gly Gly Ser Phe Gly Gly Arg Ser Ser Gly Ser Pro 
    290                 295                 300                 


Tyr Gly Gly Gly Tyr Gly Ser Gly Gly Gly Ser Gly Gly Tyr Gly Ser 
305                 310                 315                 320 


Arg Arg Phe 
            


<210> 7391
<211> 96
<212> PRT
<213> Homo sapiens

<400> 7391
Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys Gln Ile 
1               5                   10                  15      


Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val Val Ala Leu Asn Val 
            20                  25                  30          


Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu Leu Ala 
        35                  40                  45              


Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp Ser Val 
    50                  55                  60                  


Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu Ala Ala 
65                  70                  75                  80  


Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Pro Phe Ser 
                85                  90                  95      


<210> 7392
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7392
Met Thr Asp Val Pro Ala Thr Phe Thr Gln Ala Glu Cys Asn Gly Asp 
1               5                   10                  15      


Lys Pro Pro Glu Asn Gly Gln Gln Thr Ile Thr Lys Ile Ser Glu Glu 
            20                  25                  30          


Leu Thr Asp Val Asp Ser Pro Leu Pro His Tyr Arg Val Glu Pro Ser 
        35                  40                  45              


Leu Glu Gly Ala Leu Thr Lys Gly Ser Gln Glu Glu Arg Arg Lys Leu 
    50                  55                  60                  


Gln Gly Asn Met Leu Leu Asn Ser Ser Met Glu Asp Lys Met Leu Lys 
65                  70                  75                  80  


Glu Asn Pro Glu Glu Lys Leu Phe Ile Val His Lys Ala Ile Thr Asp 
                85                  90                  95      


Leu Ser Leu Gln Glu Thr Ser Ala Asp Glu Met Thr Phe Arg Glu Gly 
            100                 105                 110         


His Gln Trp Glu Lys Ile Pro Leu Ser Gly Ser Asn Gln Glu Ile Arg 
        115                 120                 125             


Arg Gln Lys Glu Arg Ile Thr Glu Gln Pro Leu Lys Glu Glu Glu Asp 
    130                 135                 140                 


Glu Asp Arg Lys Asn Lys Gly His Gln Ala Ala Glu Ile Glu Trp Leu 
145                 150                 155                 160 


<210> 7393
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7393
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Glu Lys Ile Leu Asn His Leu Ser Thr 
65                  70                  75                  80  


Leu Arg Arg Asp Arg Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu 
                85                  90                  95      


Ala Asp Ile Leu Ala Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr 
            100                 105                 110         


Ile Val Ala Glu Phe Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu 
        115                 120                 125             


Glu His Leu Leu Glu Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu 
    130                 135                 140                 


Gly Arg Glu Lys Phe Lys Ser Arg Gly Val Gly Glu Leu Ala Arg 
145                 150                 155                 


<210> 7394
<211> 143
<212> PRT
<213> Homo sapiens

<400> 7394
Met Asp Ser Ser Gln Gln Lys Thr Phe Arg Gly His Asp Ala Pro Val 
1               5                   10                  15      


Leu Ser Leu Ser Phe Asp Pro Lys Asp Ile Phe Leu Ala Ser Ala Ser 
            20                  25                  30          


Cys Asp Gly Ser Val Arg Val Trp Gln Ile Ser Asp Gln Thr Cys Ala 
        35                  40                  45              


Ile Ser Trp Pro Leu Leu Gln Lys Cys Asn Asp Val Ile Asn Ala Lys 
    50                  55                  60                  


Ser Ile Cys Arg Leu Ala Trp Gln Pro Lys Ser Gly Lys Leu Leu Ala 
65                  70                  75                  80  


Ile Pro Val Glu Lys Ser Val Lys Leu Tyr Arg Arg Glu Ser Trp Ser 
                85                  90                  95      


His Gln Phe Asp Leu Ser Asp Asn Phe Ile Ser Gln Thr Leu Asn Ile 
            100                 105                 110         


Val Thr Trp Ser Pro Cys Gly Gln Tyr Leu Ala Ala Gly Ser Ile Asn 
        115                 120                 125             


Gly Leu Ile Ile Val Trp Asn Val Glu Thr Lys Asp Cys Met Glu 
    130                 135                 140             


<210> 7395
<211> 702
<212> PRT
<213> Homo sapiens

<400> 7395
Met Thr Glu Arg Cys Ser Leu Trp Ser Ala Leu Ser Ala Ala Ala Cys 
1               5                   10                  15      


Cys Phe Tyr Arg Gly Ser Phe Val Gln Val Gln Phe Ser Lys Glu Lys 
            20                  25                  30          


Tyr Ile Leu Asp Ser Ser Pro Glu Lys Leu His Lys Glu Leu Glu Glu 
        35                  40                  45              


Glu Leu Lys Leu Ser Ser Thr Asp Leu Arg Ser His Ala Trp Tyr His 
    50                  55                  60                  


Gly Arg Ile Pro Arg Glu Val Ser Glu Thr Leu Val Gln Arg Asn Gly 
65                  70                  75                  80  


Asp Phe Leu Ile Arg Asp Ser Leu Thr Ser Leu Gly Asp Tyr Val Leu 
                85                  90                  95      


Thr Cys Arg Trp Arg Asn Gln Ala Leu His Phe Lys Ile Asn Lys Val 
            100                 105                 110         


Val Val Lys Ala Gly Glu Ser Tyr Thr His Ile Gln Tyr Leu Phe Glu 
        115                 120                 125             


Gln Glu Ser Phe Asp His Val Pro Ala Leu Val Arg Tyr His Val Gly 
    130                 135                 140                 


Ser Arg Lys Ala Val Ser Glu Gln Ser Gly Ala Ile Ile Tyr Cys Pro 
145                 150                 155                 160 


Val Asn Arg Thr Phe Pro Leu Arg Tyr Leu Glu Ala Ser Tyr Gly Leu 
                165                 170                 175     


Gly Gln Gly Ser Ser Lys Pro Ala Ser Pro Val Ser Pro Ser Gly Pro 
            180                 185                 190         


Lys Gly Ser His Met Lys Arg Arg Ser Val Thr Met Thr Asp Gly Leu 
        195                 200                 205             


Thr Ala Asp Lys Val Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr Ser 
    210                 215                 220                 


Leu Pro Arg Pro Arg Asp Ser Ile Arg Ser Cys Ala Leu Ser Met Asp 
225                 230                 235                 240 


Gln Ile Pro Asp Leu His Ser Pro Met Ser Pro Ile Ser Glu Ser Pro 
                245                 250                 255     


Ser Ser Pro Ala Tyr Ser Thr Val Thr Arg Val His Ala Ala Pro Ala 
            260                 265                 270         


Ala Pro Ser Ala Thr Ala Leu Pro Ala Ser Pro Val Ala Arg Arg Ser 
        275                 280                 285             


Ser Glu Pro Gln Leu Cys Pro Gly Ser Ala Pro Lys Thr His Gly Glu 
    290                 295                 300                 


Ser Asp Lys Gly Pro His Thr Ser Pro Ser His Thr Leu Gly Lys Ala 
305                 310                 315                 320 


Ser Pro Ser Pro Ser Leu Ser Ser Tyr Ser Asp Pro Asp Ser Gly His 
                325                 330                 335     


Tyr Cys Gln Leu Gln Pro Pro Val Arg Gly Ser Arg Glu Trp Ala Ala 
            340                 345                 350         


Thr Glu Thr Ser Ser Gln Gln Ala Arg Ser Tyr Gly Glu Arg Leu Lys 
        355                 360                 365             


Glu Leu Ser Glu Asn Gly Ala Pro Glu Gly Asp Trp Gly Lys Thr Phe 
    370                 375                 380                 


Thr Val Pro Ile Val Glu Val Thr Ser Ser Phe Asn Pro Ala Thr Phe 
385                 390                 395                 400 


Gln Ser Leu Leu Ile Pro Arg Asp Asn Arg Pro Leu Glu Val Gly Leu 
                405                 410                 415     


Leu Arg Lys Val Lys Glu Leu Leu Ala Glu Val Asp Ala Arg Thr Leu 
            420                 425                 430         


Ala Arg His Val Thr Lys Val Asp Cys Leu Val Ala Arg Ile Leu Gly 
        435                 440                 445             


Val Thr Lys Glu Met Gln Thr Leu Met Gly Val Arg Trp Gly Met Glu 
    450                 455                 460                 


Leu Leu Thr Leu Pro His Gly Arg Gln Leu Arg Leu Asp Leu Leu Glu 
465                 470                 475                 480 


Arg Phe His Thr Met Ser Ile Met Leu Ala Val Asp Ile Leu Gly Cys 
                485                 490                 495     


Thr Gly Ser Ala Glu Glu Arg Ala Ala Leu Leu His Lys Thr Ile Gln 
            500                 505                 510         


Leu Ala Ala Glu Leu Arg Gly Thr Met Gly Asn Met Phe Ser Phe Ala 
        515                 520                 525             


Ala Val Met Gly Ala Leu Asp Met Ala Gln Ile Ser Arg Leu Glu Gln 
    530                 535                 540                 


Thr Trp Val Thr Leu Arg Gln Arg His Thr Glu Gly Ala Ile Leu Tyr 
545                 550                 555                 560 


Glu Lys Lys Leu Lys Pro Phe Leu Lys Ser Leu Asn Glu Gly Lys Glu 
                565                 570                 575     


Gly Pro Pro Leu Ser Asn Thr Thr Phe Pro His Val Leu Pro Leu Ile 
            580                 585                 590         


Thr Leu Leu Glu Cys Asp Ser Ala Pro Pro Glu Gly Pro Glu Pro Trp 
        595                 600                 605             


Gly Ser Thr Glu His Gly Val Glu Val Val Leu Ala His Leu Glu Ala 
    610                 615                 620                 


Ala Arg Thr Val Ala His His Gly Gly Leu Tyr His Thr Asn Ala Glu 
625                 630                 635                 640 


Val Lys Leu Gln Gly Phe Gln Ala Arg Pro Glu Leu Leu Glu Val Phe 
                645                 650                 655     


Ser Thr Glu Phe Gln Met Arg Leu Leu Trp Gly Ser Gln Gly Ala Ser 
            660                 665                 670         


Ser Ser Gln Ala Arg Arg Tyr Glu Lys Phe Asp Lys Val Leu Thr Ala 
        675                 680                 685             


Leu Ser His Lys Leu Glu Pro Ala Val Arg Ser Ser Glu Leu 
    690                 695                 700         


<210> 7396
<211> 194
<212> PRT
<213> Homo sapiens

<400> 7396
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala 
        35                  40                  45              


Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala 
    50                  55                  60                  


Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro 
                85                  90                  95      


Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys 
            100                 105                 110         


Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr 
        115                 120                 125             


Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro 
    130                 135                 140                 


Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr 
                165                 170                 175     


Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser 
            180                 185                 190         


Leu Gln 
        


<210> 7397
<211> 777
<212> PRT
<213> Homo sapiens

<400> 7397
Met Glu Pro Lys Glu Ala Thr Gly Lys Glu Asn Met Val Thr Lys Lys 
1               5                   10                  15      


Lys Asn Leu Ala Phe Leu Arg Ser Arg Leu Tyr Met Leu Glu Arg Arg 
            20                  25                  30          


Lys Thr Asp Thr Val Val Glu Ser Ser Val Ser Gly Asp His Ser Gly 
        35                  40                  45              


Thr Leu Arg Arg Ser Gln Ser Asp Arg Thr Glu Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Gln Glu Lys Met Thr Pro Gln Gly Glu Cys Ser Val Ala Glu Thr Leu 
65                  70                  75                  80  


Thr Pro Glu Glu Glu His His Met Lys Arg Met Met Ala Lys Arg Glu 
                85                  90                  95      


Lys Ile Ile Lys Glu Leu Ile Gln Thr Glu Lys Asp Tyr Leu Asn Asp 
            100                 105                 110         


Leu Glu Leu Cys Val Arg Glu Val Val Gln Pro Leu Arg Asn Lys Lys 
        115                 120                 125             


Thr Asp Arg Leu Asp Val Asp Ser Leu Phe Ser Asn Ile Glu Ser Val 
    130                 135                 140                 


His Gln Ile Ser Ala Lys Leu Leu Ser Leu Leu Glu Glu Ala Thr Thr 
145                 150                 155                 160 


Asp Val Glu Pro Ala Met Gln Val Ile Gly Glu Val Phe Leu Gln Ile 
                165                 170                 175     


Lys Gly Pro Leu Glu Asp Ile Tyr Lys Ile Tyr Cys Tyr His His Asp 
            180                 185                 190         


Glu Ala His Ser Ile Leu Glu Ser Tyr Glu Lys Glu Glu Glu Leu Lys 
        195                 200                 205             


Glu His Leu Ser His Cys Ile Gln Ser Leu Lys Lys Ile Tyr Met Gln 
    210                 215                 220                 


Glu Gly Lys Pro Asn Leu Leu Asp Met Gly Ser Leu Met Ile Lys Pro 
225                 230                 235                 240 


Ile Gln Arg Val Met Lys Tyr Pro Leu Leu Leu Cys Glu Leu Arg Asn 
                245                 250                 255     


Ser Thr Pro Pro Ser His Pro Asp Tyr Arg Ala Leu Asp Asp Ala Phe 
            260                 265                 270         


Ala Ala Val Lys Asp Ile Asn Val Asn Ile Asn Glu Leu Lys Arg Arg 
        275                 280                 285             


Lys Asp Leu Val Leu Lys Tyr Lys Lys Asn Asp Glu Asp Glu Ser Leu 
    290                 295                 300                 


Lys Asp Lys Leu Ser Lys Leu Asn Ile His Ser Ile Ser Lys Lys Ser 
305                 310                 315                 320 


Lys Arg Val Thr Asn His Leu Lys Ile Leu Thr Arg Gly Glu Ser Gln 
                325                 330                 335     


Val Lys Asp Asn Thr Phe Asn Arg Glu Glu Lys Leu Phe Arg Ala Leu 
            340                 345                 350         


Glu Lys Thr Val Arg Leu Cys Val Lys Asn Ile Ser Leu Cys Leu Gln 
        355                 360                 365             


His Ile Gln Asp Ala Met Pro Leu Ala Leu Gln Ser Val Met Asp Leu 
    370                 375                 380                 


Gln Glu Ile Ser Tyr Asn Lys Asp Asp Glu Met Asp Tyr Ser Glu Thr 
385                 390                 395                 400 


Leu Ser Asn Ala Leu Asn Ser Cys His Asp Phe Ala Ser His Leu Gln 
                405                 410                 415     


Arg Leu Ile Leu Thr Pro Leu Ser Ala Leu Leu Ser Leu Phe Pro Gly 
            420                 425                 430         


Pro His Lys Leu Ile Gln Lys Arg Tyr Asp Lys Leu Leu Asp Cys Asn 
        435                 440                 445             


Ser Tyr Leu Gln Arg Ser Thr Gly Glu Glu Ser Asp Leu Ala Lys Lys 
    450                 455                 460                 


Glu Tyr Glu Ala Leu Asn Ala Gln Leu Val Glu Glu Leu Gln Ala Phe 
465                 470                 475                 480 


Asn Gln Ala Ala Arg Lys Ile Leu Leu Asn Cys Leu Cys Ser Phe Ile 
                485                 490                 495     


Thr Leu Leu Arg Asp Leu Met Leu Val Ala Gln Gln Ala Tyr Ser Thr 
            500                 505                 510         


Leu Val Pro Met Pro Leu Leu Val Ser Ser Ile Ser Glu Ile Gln Asn 
        515                 520                 525             


Gln Val Leu Glu Glu Ile Gln Asn Leu Asn Cys Val Lys Glu Asn Ser 
    530                 535                 540                 


Ala Thr Phe Ile Glu Arg Lys Leu Ser Phe Glu Lys Lys Lys Pro Val 
545                 550                 555                 560 


Gln Ile Leu Pro Glu Met Pro His Gln Thr Asp Ile His Arg Ser Lys 
                565                 570                 575     


Leu Leu Ser Thr Tyr Ser Ala Glu Glu Leu Tyr Gln Ala Lys Arg Lys 
            580                 585                 590         


Cys Asn Ala Thr Gln Glu Tyr Asp Ile Asn Leu Leu Glu Gly Asp Leu 
        595                 600                 605             


Val Ala Val Ile Glu Gln Lys Asp Pro Leu Gly Ser Thr Ser Arg Trp 
    610                 615                 620                 


Leu Val Asp Thr Gly Asn Val Lys Gly Tyr Val Tyr Ser Ser Phe Leu 
625                 630                 635                 640 


Lys Pro Tyr Asn Pro Ala Lys Met Gln Lys Val Asp Ala Glu Asn Arg 
                645                 650                 655     


Phe Cys Asp Asp Asp Phe Glu Asn Ile Ser Leu Phe Val Ser Ser Arg 
            660                 665                 670         


Pro Ala Ser Asp Ser Val Thr Gly Thr Ser Glu Ser Ser Ile Gly Asp 
        675                 680                 685             


Ser Ser Ser Ser Leu Ser Gly Thr Cys Gly Lys Phe Glu Thr Asn Gly 
    690                 695                 700                 


Thr Asp Val Asp Ser Phe Gln Glu Val Asp Glu Gln Ile Phe Tyr Ala 
705                 710                 715                 720 


Val His Ala Phe Gln Ala Arg Ser Asp His Glu Leu Ser Leu Gln Glu 
                725                 730                 735     


Tyr Gln Arg Val His Ile Leu Arg Phe Cys Asp Leu Ser Gly Asn Lys 
            740                 745                 750         


Glu Trp Trp Leu Ala Glu Ala Gln Gly Gln Lys Gly Tyr Val Pro Ala 
        755                 760                 765             


Asn Tyr Leu Gly Lys Met Thr Tyr Ala 
    770                 775         


<210> 7398
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7398
Xaa Ser Gln Pro Lys Ser Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn 
1               5                   10                  15      


Ser Ser Leu Pro Thr Ala Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile 
            20                  25                  30          


Glu Glu Glu Thr Val Lys Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser 
        35                  40                  45              


Lys His Gly Pro Gly Arg Pro Lys Gly Asn Lys Asn Gln Glu Asn Val 
    50                  55                  60                  


Ser His Leu Ser Val Ser Ser Ala Ser Pro Thr Ser Ser Val Ala Ser 
65                  70                  75                  80  


Ala Ala Gly Ser Ile Thr Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu 
                85                  90                  95      


Leu Arg Asn Gly Ser Leu Gln Ser Leu Ser Val Gly Ser Ser Pro Val 
            100                 105                 110         


Gly Ser Glu Ile Ser Met Gln Tyr Arg His Asp Gly Ala Cys Pro Thr 
        115                 120                 125             


Thr Ser Ile Tyr Asn Ser Asn Asp Val Ala Val Ser Phe Pro Asn Val 
    130                 135                 140                 


Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser Ser Ser His Leu Pro 
145                 150                 155                 160 


Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly Ala Leu Ser Pro Ser 
                165                 170                 175     


Ala Val Ser Ser 
            180 


<210> 7399
<211> 127
<212> PRT
<213> Homo sapiens

<400> 7399
Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys 
        115                 120                 125         


<210> 7400
<211> 560
<212> PRT
<213> Homo sapiens

<400> 7400
Met Ser Glu His Ser Arg Asn Ser Asp Gln Glu Glu Leu Leu Asp Glu 
1               5                   10                  15      


Glu Ile Asn Glu Asp Glu Ile Leu Ala Asn Leu Ser Ala Glu Glu Leu 
            20                  25                  30          


Lys Glu Leu Gln Ser Glu Met Glu Val Met Ala Pro Asp Pro Ser Leu 
        35                  40                  45              


Pro Val Gly Met Ile Gln Lys Asp Gln Thr Asp Lys Pro Pro Thr Gly 
    50                  55                  60                  


Asn Phe Asn His Lys Ser Leu Val Asp Tyr Met Tyr Trp Glu Lys Ala 
65                  70                  75                  80  


Ser Arg Arg Met Leu Glu Glu Glu Arg Val Pro Val Thr Phe Val Lys 
                85                  90                  95      


Ser Glu Glu Lys Thr Gln Glu Glu His Glu Glu Ile Glu Lys Arg Asn 
            100                 105                 110         


Lys Asn Met Ala Gln Tyr Leu Lys Glu Lys Leu Asn Asn Glu Ile Val 
        115                 120                 125             


Ala Asn Lys Arg Glu Ser Lys Gly Ser Ser Asn Ile Gln Glu Thr Asp 
    130                 135                 140                 


Glu Glu Asp Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp Glu Gly Glu 
145                 150                 155                 160 


Asp Asp Gly Glu Glu Ser Glu Glu Thr Asn Arg Glu Glu Glu Gly Lys 
                165                 170                 175     


Ala Lys Glu Gln Ile Arg Asn Cys Glu Asn Asn Cys Gln Gln Val Thr 
            180                 185                 190         


Asp Lys Ala Phe Lys Glu Gln Arg Asp Arg Pro Glu Ala Gln Glu Gln 
        195                 200                 205             


Ser Glu Lys Lys Ile Ser Lys Leu Asp Pro Lys Lys Leu Ala Leu Asp 
    210                 215                 220                 


Thr Ser Phe Leu Lys Val Ser Thr Arg Pro Ser Gly Asn Gln Thr Asp 
225                 230                 235                 240 


Leu Asp Gly Ser Leu Arg Arg Val Arg Lys Asn Asp Pro Asp Met Lys 
                245                 250                 255     


Glu Leu Asn Leu Asn Asn Ile Glu Asn Ile Pro Lys Glu Met Leu Leu 
            260                 265                 270         


Asp Phe Val Asn Ala Met Lys Lys Asn Lys His Ile Lys Thr Phe Ser 
        275                 280                 285             


Leu Ala Asn Val Gly Ala Asp Glu Asn Val Ala Phe Ala Leu Ala Asn 
    290                 295                 300                 


Met Leu Arg Glu Asn Arg Ser Ile Thr Thr Leu Asn Ile Glu Ser Asn 
305                 310                 315                 320 


Phe Ile Thr Gly Lys Gly Ile Val Ala Ile Met Arg Cys Leu Gln Phe 
                325                 330                 335     


Asn Glu Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Met Leu 
            340                 345                 350         


Gly His His Ala Glu Met Glu Ile Ala Arg Leu Leu Lys Ala Asn Asn 
        355                 360                 365             


Thr Leu Leu Lys Met Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met 
    370                 375                 380                 


Val Val Thr Asn Leu Leu Thr Arg Asn Gln Asp Lys Gln Arg Gln Lys 
385                 390                 395                 400 


Arg Gln Glu Glu Gln Lys Gln Gln Gln Leu Lys Glu Gln Lys Lys Leu 
                405                 410                 415     


Ile Ala Met Leu Glu Asn Gly Leu Gly Leu Pro Pro Gly Met Trp Glu 
            420                 425                 430         


Leu Leu Gly Gly Pro Lys Pro Asp Ser Arg Met Gln Glu Phe Phe Gln 
        435                 440                 445             


Pro Pro Pro Pro Arg Pro Pro Asn Pro Gln Asn Val Pro Phe Ser Gln 
    450                 455                 460                 


Arg Ser Glu Met Met Lys Lys Pro Ser Gln Ala Pro Lys Tyr Arg Thr 
465                 470                 475                 480 


Asp Pro Asp Ser Phe Arg Val Val Lys Leu Lys Arg Ile Gln Arg Lys 
                485                 490                 495     


Ser Arg Met Pro Glu Ala Arg Glu Pro Pro Glu Lys Thr Asn Leu Lys 
            500                 505                 510         


Asp Val Ile Lys Thr Leu Lys Pro Val Pro Arg Asn Arg Pro Pro Pro 
        515                 520                 525             


Leu Val Glu Ile Thr Pro Arg Asp Gln Leu Leu Asn Asp Ile Arg His 
    530                 535                 540                 


Ser Ser Val Ala Tyr Leu Lys Pro Val Gln Leu Pro Lys Glu Leu Ala 
545                 550                 555                 560 


<210> 7401
<211> 16
<212> PRT
<213> Homo sapiens

<400> 7401
Met Cys Thr Ser Glu Thr Phe Gln Ala Leu Asp Thr Phe Glu Ala Arg 
1               5                   10                  15      


<210> 7402
<211> 170
<212> PRT
<213> Homo sapiens

<400> 7402
Met Pro Ile Leu Leu Phe Leu Ile Asp Thr Ser Ala Ser Met Asn Gln 
1               5                   10                  15      


Arg Ser His Leu Gly Thr Thr Tyr Leu Asp Thr Ala Lys Gly Ala Val 
            20                  25                  30          


Glu Thr Phe Met Lys Leu Arg Ala Arg Asp Pro Ala Ser Arg Gly Asp 
        35                  40                  45              


Arg Tyr Met Leu Val Thr Phe Glu Glu Pro Pro Tyr Ala Ile Lys Ala 
    50                  55                  60                  


Gly Trp Lys Glu Asn His Ala Thr Phe Met Asn Glu Leu Lys Asn Leu 
65                  70                  75                  80  


Gln Ala Glu Gly Leu Thr Thr Leu Gly Gln Ser Leu Arg Thr Ala Phe 
                85                  90                  95      


Asp Leu Leu Asn Leu Asn Arg Leu Val Thr Gly Ile Asp Asn Tyr Gly 
            100                 105                 110         


Gln Gly Arg Asn Pro Phe Phe Leu Glu Pro Ala Ile Ile Ile Thr Ile 
        115                 120                 125             


Thr Asp Gly Ser Lys Leu Thr Thr Thr Ser Gly Val Gln Asp Glu Ala 
    130                 135                 140                 


Val His Ile Leu Cys Val Leu Gln Glu Cys Leu Ile Ser Val Trp Ser 
145                 150                 155                 160 


Pro Trp Cys Arg Lys Tyr Lys Val Gly Trp 
                165                 170 


<210> 7403
<211> 67
<212> PRT
<213> Homo sapiens

<400> 7403
Met Ser Arg Arg Arg Phe Asp Cys Arg Ser Ile Ser Gly Leu Leu Thr 
1               5                   10                  15      


Thr Thr Pro Gln Ile Pro Ile Lys Met Glu Asn Phe Asn Asn Phe Tyr 
            20                  25                  30          


Ile Leu Thr Ser Lys Glu Leu Gly Arg Gly Lys Phe Ala Val Val Arg 
        35                  40                  45              


Gln Cys Ile Ser Lys Ser Thr Gly Gln Glu Tyr Ala Ala Lys Phe Leu 
    50                  55                  60                  


Lys Lys Arg 
65          


<210> 7404
<211> 368
<212> PRT
<213> Homo sapiens

<400> 7404
Met Leu Ser Lys Arg Gly Cys His Ala Arg Ile Tyr Ala Asp Phe Pro 
1               5                   10                  15      


Ile Arg Arg Leu Ile Ser Gln Arg Ser Ser Leu Glu Thr Leu Glu Asp 
            20                  25                  30          


Ile Glu Glu Asn Ala Pro Leu Arg Arg Cys Arg Thr Leu Ser Gly Ser 
        35                  40                  45              


Pro Arg Pro Lys Asn Phe Lys Lys Ile His Phe Ile Lys Asn Met Arg 
    50                  55                  60                  


Gln His Asp Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly Arg Arg 
65                  70                  75                  80  


Ser Phe Cys Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser Thr Gln 
                85                  90                  95      


Val Gly Asp Leu Lys Leu Asp Gly Gly Arg Gln Ser Thr Gly Ala Val 
            100                 105                 110         


Ser Leu Lys Glu Ile Ile Gly Leu Glu Gly Val Glu Leu Gly Ala Asp 
        115                 120                 125             


Gly Lys Thr Val Ser Tyr Thr Gln Phe Leu Leu Pro Thr Asn Ala Phe 
    130                 135                 140                 


Gly Ala Arg Arg Asn Thr Ile Asp Ser Thr Ser Ser Phe Ser Gln Phe 
145                 150                 155                 160 


Arg Asn Leu Ser His Arg Ser Leu Ser Ile Gly Arg Ala Ser Gly Thr 
                165                 170                 175     


Gln Gly Ser Leu Asp Thr Gly Ser Asp Leu Gly Asp Phe Met Asp Tyr 
            180                 185                 190         


Asp Pro Asn Leu Leu Asp Asp Pro Gln Trp Pro Cys Gly Lys His Lys 
        195                 200                 205             


Arg Val Leu Ile Phe Pro Ser Tyr Met Thr Thr Val Ile Asp Tyr Val 
    210                 215                 220                 


Lys Pro Ser Asp Leu Lys Lys Asp Met Asn Glu Thr Phe Lys Glu Lys 
225                 230                 235                 240 


Phe Pro His Ile Lys Leu Thr Leu Ser Lys Ile Arg Ser Leu Lys Arg 
                245                 250                 255     


Glu Met Arg Lys Leu Ala Gln Glu Asp Cys Gly Leu Glu Glu Pro Thr 
            260                 265                 270         


Val Ala Met Ala Phe Val Tyr Phe Glu Lys Leu Ala Leu Lys Gly Lys 
        275                 280                 285             


Leu Asn Lys Gln Asn Arg Lys Leu Cys Ala Gly Ala Cys Val Leu Leu 
    290                 295                 300                 


Ala Ala Lys Ile Gly Ser Asp Leu Lys Lys His Glu Val Lys His Leu 
305                 310                 315                 320 


Ile Asp Lys Leu Glu Glu Lys Phe Arg Leu Asn Arg Arg Glu Leu Ile 
                325                 330                 335     


Ala Phe Glu Phe Pro Val Leu Val Ala Leu Glu Phe Ala Leu His Leu 
            340                 345                 350         


Pro Glu His Glu Val Met Pro His Tyr Arg Arg Leu Val Gln Ser Ser 
        355                 360                 365             


<210> 7405
<211> 264
<212> PRT
<213> Homo sapiens

<400> 7405
Met Thr Asp Val Pro Ala Thr Phe Thr Gln Ala Glu Cys Asn Gly Asp 
1               5                   10                  15      


Lys Pro Pro Glu Asn Gly Gln Gln Thr Ile Thr Lys Ile Ser Glu Glu 
            20                  25                  30          


Leu Thr Asp Val Asp Ser Pro Leu Pro His Tyr Arg Val Glu Pro Ser 
        35                  40                  45              


Leu Glu Gly Ala Leu Thr Lys Gly Ser Gln Glu Glu Arg Arg Lys Leu 
    50                  55                  60                  


Gln Gly Asn Met Leu Leu Asn Ser Ser Met Glu Asp Lys Met Leu Lys 
65                  70                  75                  80  


Glu Thr Ser Ala Asp Glu Met Thr Phe Arg Glu Gly His Gln Trp Glu 
                85                  90                  95      


Lys Ile Pro Leu Ser Gly Ser Asn Gln Glu Ile Arg Arg Gln Lys Glu 
            100                 105                 110         


Arg Ile Thr Glu Gln Pro Leu Lys Glu Glu Glu Asp Glu Asp Arg Lys 
        115                 120                 125             


Asn Lys Gly His Gln Ala Ala Glu Ile Glu Trp Leu Gly Phe Arg Lys 
    130                 135                 140                 


Pro Ser Gln Ala Asp Met Leu His Ser Lys His Asp Glu Glu Gln Lys 
145                 150                 155                 160 


Val Trp Asp Glu Glu Ile Asp Asp Asp Asp Asp Asp Asn Cys Asn Asn 
                165                 170                 175     


Asp Glu Asp Glu Val Arg Val Ile Glu Phe Lys Lys Lys His Glu Glu 
            180                 185                 190         


Val Ser Gln Phe Lys Glu Glu Gly Asp Ala Ser Glu Asp Ser Pro Leu 
        195                 200                 205             


Ser Ser Ala Ser Ser Gln Ala Val Thr Pro Asp Glu Gln Pro Thr Leu 
    210                 215                 220                 


Gly Lys Lys Ser Asp Ile Ser Arg Asn Ala Tyr Ser Arg Tyr Asn Thr 
225                 230                 235                 240 


Ile Ser Tyr Arg Lys Ile Arg Lys Gly Asn Thr Lys Gln Arg Ile Asp 
                245                 250                 255     


Glu Phe Glu Ser Met Met His Leu 
            260                 


<210> 7406
<211> 1433
<212> PRT
<213> Homo sapiens

<400> 7406
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile Asn Asp Leu Ala Met Gln Tyr Tyr Ile Gln Asp 
    130                 135                 140                 


Arg Arg Glu Val Tyr Arg Ile Leu Gln Glu Glu Gly Ile Asp Leu Pro 
145                 150                 155                 160 


Arg Tyr Ala Val Leu Asn Arg Asp Pro Ala Arg Pro Glu Glu Cys Asn 
                165                 170                 175     


Leu Ile Glu Gly Glu Asp Gln Val Glu Val Asn Gly Ala Val Phe Pro 
            180                 185                 190         


Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val Tyr 
        195                 200                 205             


Ile Tyr Tyr Pro Ser Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe Arg 
    210                 215                 220                 


Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Ser Val Arg 
225                 230                 235                 240 


Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly Thr 
                245                 250                 255     


Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu Ala 
            260                 265                 270         


Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu Gly 
        275                 280                 285             


Lys Glu Ile Arg Tyr Pro Val Met Leu Thr Ala Met Glu Lys Leu Val 
    290                 295                 300                 


Ala Arg Lys Val Cys Val Ala Phe Lys Gln Thr Val Cys Gly Phe Asp 
305                 310                 315                 320 


Leu Leu Arg Ala Asn Gly His Ser Phe Val Cys Asp Val Asn Gly Phe 
                325                 330                 335     


Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys Ile 
            340                 345                 350         


Leu Gly Asn Thr Ile Met Arg Glu Leu Ala Pro Gln Phe Gln Ile Pro 
        355                 360                 365             


Trp Ser Ile Pro Thr Glu Ala Glu Asp Ile Pro Ile Val Pro Thr Thr 
    370                 375                 380                 


Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Ile Ile Arg His 
385                 390                 395                 400 


Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met Glu Val Lys His Pro 
                405                 410                 415     


Arg Phe Phe Ala Leu Phe Glu Lys His Gly Gly Tyr Lys Thr Gly Lys 
            420                 425                 430         


Leu Lys Leu Lys Arg Pro Glu Gln Leu Gln Glu Val Leu Asp Ile Thr 
        435                 440                 445             


Arg Leu Leu Leu Ala Glu Leu Glu Lys Glu Pro Gly Gly Glu Ile Glu 
    450                 455                 460                 


Glu Lys Thr Gly Lys Leu Glu Gln Leu Lys Ser Val Leu Glu Met Tyr 
465                 470                 475                 480 


Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Tyr Pro 
                485                 490                 495     


His Gly Val Lys Ala Ser Asn Glu Gly Gln Asp Pro Gln Arg Glu Thr 
            500                 505                 510         


Leu Ala Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr 
        515                 520                 525             


Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys 
    530                 535                 540                 


Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly 
545                 550                 555                 560 


Leu Leu Arg Leu His Ser Thr Phe Arg His Asp Leu Lys Ile Tyr Ala 
                565                 570                 575     


Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly 
            580                 585                 590         


Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val 
        595                 600                 605             


Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Gly Asp Ser Leu 
    610                 615                 620                 


Ser Ser Cys Gln His Arg Val Lys Ala Arg Leu His His Ile Leu Gln 
625                 630                 635                 640 


Gln Asp Ala Pro Phe Gly Pro Glu Asp Tyr Asp Gln Leu Ala Pro Thr 
                645                 650                 655     


Arg Ser Thr Ser Leu Leu Asn Ser Met Thr Ile Ile Gln Asn Pro Val 
            660                 665                 670         


Lys Val Cys Asp Gln Val Phe Ala Leu Ile Glu Asn Leu Thr His Gln 
        675                 680                 685             


Ile Arg Glu Arg Met Gln Asp Pro Arg Ser Val Asp Leu Gln Leu Tyr 
    690                 695                 700                 


His Ser Glu Thr Leu Glu Leu Met Leu Gln Arg Trp Ser Lys Leu Glu 
705                 710                 715                 720 


Arg Asp Phe Arg Gln Lys Ser Gly Arg Tyr Asp Ile Ser Lys Ile Pro 
                725                 730                 735     


Asp Ile Tyr Asp Cys Val Lys Tyr Asp Val Gln His Asn Gly Ser Leu 
            740                 745                 750         


Gly Leu Gln Gly Thr Ala Glu Leu Leu Arg Leu Ser Lys Ala Leu Ala 
        755                 760                 765             


Asp Val Val Ile Pro Gln Glu Tyr Gly Ile Ser Arg Glu Glu Lys Leu 
    770                 775                 780                 


Glu Ile Ala Val Gly Phe Cys Leu Pro Leu Leu Arg Lys Ile Leu Leu 
785                 790                 795                 800 


Asp Leu Gln Arg Thr His Glu Asp Glu Ser Val Asn Lys Leu His Pro 
                805                 810                 815     


Leu Cys Tyr Leu Arg Tyr Ser Arg Gly Val Leu Ser Pro Gly Arg His 
            820                 825                 830         


Val Arg Thr Arg Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu 
        835                 840                 845             


Leu Ser Val Phe Arg Tyr Gly Gly Leu Leu Asp Glu Thr Gln Asp Ala 
    850                 855                 860                 


Gln Trp Gln Arg Ala Leu Asp Tyr Leu Ser Ala Ile Ser Glu Leu Asn 
865                 870                 875                 880 


Tyr Met Thr Gln Ile Val Ile Met Leu Tyr Glu Asp Asn Thr Gln Asp 
                885                 890                 895     


Pro Leu Ser Glu Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly 
            900                 905                 910         


Val Lys Gly Val Glu Glu Glu Gly Ser Ala Pro Ala Gly Cys Gly Phe 
        915                 920                 925             


Arg Pro Ala Ser Ser Glu Asn Glu Glu Met Lys Thr Asn Gln Gly Ser 
    930                 935                 940                 


Met Glu Asn Leu Cys Pro Gly Lys Ala Ser Asp Glu Pro Asp Arg Ala 
945                 950                 955                 960 


Leu Gln Thr Ser Pro Gln Pro Pro Glu Gly Pro Gly Leu Pro Arg Arg 
                965                 970                 975     


Ser Pro Leu Ile Arg Asn Arg Lys Ala Gly Ser Met Glu Val Leu Ser 
            980                 985                 990         


Glu Thr Ser Ser Ser Arg Pro Gly  Gly Tyr Arg Leu Phe  Ser Ser Ser 
        995                 1000                 1005             


Arg Pro  Pro Thr Glu Met Lys  Gln Ser Gly Leu Gly  Ser Gln Cys 
    1010                 1015                 1020             


Thr Gly  Leu Phe Ser Thr Thr  Val Leu Gly Gly Ser  Ser Ser Ala 
    1025                 1030                 1035             


Pro Asn  Leu Gln Asp Tyr Ala  Arg Ser His Gly Lys  Lys Leu Pro 
    1040                 1045                 1050             


Pro Ala  Ser Leu Lys His Arg  Asp Glu Leu Leu Phe  Val Pro Ala 
    1055                 1060                 1065             


Val Lys  Arg Phe Ser Val Ser  Phe Ala Lys His Pro  Thr Asn Gly 
    1070                 1075                 1080             


Phe Glu  Gly Cys Ser Met Val  Pro Thr Ile Tyr Pro  Leu Glu Thr 
    1085                 1090                 1095             


Leu His  Asn Ala Leu Ser Leu  Arg Gln Val Ser Glu  Phe Leu Ser 
    1100                 1105                 1110             


Arg Val  Cys Gln Arg His Thr  Asp Ala Gln Ala Gln  Ala Ser Ala 
    1115                 1120                 1125             


Ala Leu  Phe Asp Ser Met His  Ser Ser Gln Ala Ser  Asp Asn Pro 
    1130                 1135                 1140             


Phe Ser  Pro Pro Arg Thr Leu  His Ser Pro Pro Leu  Gln Leu Gln 
    1145                 1150                 1155             


Gln Arg  Ser Glu Lys Pro Pro  Trp Tyr Ser Ser Gly  Pro Ser Ser 
    1160                 1165                 1170             


Thr Val  Ser Ser Ala Gly Pro  Ser Ser Pro Thr Thr  Val Asp Gly 
    1175                 1180                 1185             


Asn Ser  Gln Phe Gly Phe Ser  Asp Gln Pro Ser Leu  Asn Ser His 
    1190                 1195                 1200             


Val Ala  Glu Glu His Gln Gly  Leu Gly Leu Leu Gln  Glu Thr Pro 
    1205                 1210                 1215             


Gly Ser  Gly Ala Gln Glu Leu  Ser Ile Glu Gly Glu  Gln Glu Leu 
    1220                 1225                 1230             


Phe Glu  Pro Asn Gln Ser Pro  Gln Val Pro Pro Met  Glu Thr Ser 
    1235                 1240                 1245             


Gln Pro  Tyr Glu Glu Val Ser  Gln Pro Cys Gln Glu  Val Pro Asp 
    1250                 1255                 1260             


Ile Ser  Gln Pro Cys Gln Asp  Ile Ser Glu Ala Leu  Ser Gln Pro 
    1265                 1270                 1275             


Cys Gln  Lys Val Pro Asp Ile  Ser Gln Gln Cys Gln  Glu Asn His 
    1280                 1285                 1290             


Asp Asn  Gly Asn His Thr Cys  Gln Glu Val Pro His  Ile Ser Gln 
    1295                 1300                 1305             


Pro Cys  Gln Lys Ser Ser Gln  Leu Cys Gln Lys Val  Ser Glu Glu 
    1310                 1315                 1320             


Val Cys  Gln Leu Cys Leu Glu  Asn Ser Glu Glu Val  Ser Gln Pro 
    1325                 1330                 1335             


Cys Gln  Gly Val Ser Val Glu  Val Gly Lys Leu Val  His Lys Phe 
    1340                 1345                 1350             


His Val  Gly Val Gly Ser Leu  Val Gln Glu Thr Leu  Val Glu Val 
    1355                 1360                 1365             


Gly Ser  Pro Ala Glu Glu Ile  Pro Glu Glu Val Ile  Gln Pro Tyr 
    1370                 1375                 1380             


Gln Glu  Phe Ser Val Glu Val  Gly Arg Leu Ala Gln  Glu Thr Ser 
    1385                 1390                 1395             


Ala Ile  Asn Leu Leu Ser Gln  Gly Ile Pro Glu Ile  Asp Lys Pro 
    1400                 1405                 1410             


Ser Gln  Glu Phe Pro Glu Glu  Ile Asp Leu Gln Ala  Gln Glu Val 
    1415                 1420                 1425             


Pro Glu  Glu Ile Asn 
    1430             


<210> 7407
<211> 269
<212> PRT
<213> Homo sapiens

<400> 7407
Met Phe Pro Ala Leu Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Glu Asp Phe Met Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys 
            20                  25                  30          


Ala Gln Arg Gly Ser Leu Pro Asn Ser Ala Thr His Gln His Val Arg 
        35                  40                  45              


Lys Asn Asn Pro Gln Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp 
    50                  55                  60                  


Asp Leu Ile Pro Asp Thr Leu Gln Lys Glu Lys Leu Leu Tyr Ser His 
65                  70                  75                  80  


Met Leu Ser Leu Pro His Leu Arg Ser Arg Gln Leu Leu Tyr Asp Glu 
                85                  90                  95      


Leu Asp Glu Val Asn Pro Arg Leu Arg Glu Pro Gln Glu Leu Phe Ser 
            100                 105                 110         


Ile Leu Ser Thr Lys Arg Pro Leu Gln Ala Pro Arg Trp Pro Ile Glu 
        115                 120                 125             


Cys Glu Val Ile Lys Glu Asn Ile His His Ile Glu Trp Ala Pro Pro 
    130                 135                 140                 


Gln Pro Glu Tyr Phe Tyr Gln Pro Lys Gly Asn Glu Lys Val Pro Glu 
145                 150                 155                 160 


Ile Val Gly Glu Lys Lys Gly Thr Val Val Tyr Gln Leu Asp Ser Val 
                165                 170                 175     


Pro Ile Glu Gly Ser Tyr Phe Thr Ser Ser Arg Val Gly Gly Lys Arg 
            180                 185                 190         


Gly Ile Val Lys Glu Leu Ala Val Thr Leu Gln Gly Pro Glu Asp Asn 
        195                 200                 205             


Thr Leu Leu Phe Glu Ser Arg Phe Glu Ser Gly Asn Leu Gln Lys Ala 
    210                 215                 220                 


Val Arg Val Asp Pro Met Ser Met Asn Ser Pro Cys Glu Leu Thr Ser 
225                 230                 235                 240 


Thr Leu Thr Asn Thr Leu Ser Gly Phe Ile Phe Val Phe Arg Thr Pro 
                245                 250                 255     


Glu Lys Met Leu Pro Ile Ala Ser Pro Leu Ser Thr Cys 
            260                 265                 


<210> 7408
<211> 324
<212> PRT
<213> Homo sapiens

<400> 7408
Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 
1               5                   10                  15      


Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 
            20                  25                  30          


Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 
        35                  40                  45              


Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 
    50                  55                  60                  


Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 
65                  70                  75                  80  


Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 
                85                  90                  95      


Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 
            100                 105                 110         


Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 
        115                 120                 125             


Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 
    130                 135                 140                 


Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 
145                 150                 155                 160 


Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 
                165                 170                 175     


Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 
            180                 185                 190         


Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 
        195                 200                 205             


Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 
    210                 215                 220                 


Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 
225                 230                 235                 240 


Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 
                245                 250                 255     


Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 
            260                 265                 270         


Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 
        275                 280                 285             


Asn Pro Glu Trp Leu Lys Asp Lys Gly Lys Pro Glu Arg Cys Leu Lys 
    290                 295                 300                 


Ile Pro Val Thr Val Ile His Leu Val Val Gly Leu Ser Ser Val Met 
305                 310                 315                 320 


Arg Gly Gln Ile 
                


<210> 7409
<211> 53
<212> PRT
<213> Homo sapiens

<400> 7409
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val 
    50              


<210> 7410
<211> 692
<212> PRT
<213> Homo sapiens

<400> 7410
Met Val Thr Thr Leu Gly Pro Lys Met Ala Ala Glu Trp Gly Gly Gly 
1               5                   10                  15      


Val Gly Tyr Ser Gly Ser Gly Pro Gly Arg Ser Arg Trp Arg Trp Ser 
            20                  25                  30          


Gly Ser Val Trp Val Arg Ser Val Leu Leu Leu Leu Gly Gly Leu Arg 
        35                  40                  45              


Ala Ser Ala Thr Ser Thr Pro Val Ser Leu Gly Ser Ser Pro Pro Cys 
    50                  55                  60                  


Arg His His Val Pro Ser Asp Thr Glu Val Ile Asn Lys Val His Leu 
65                  70                  75                  80  


Lys Ala Asn His Val Val Lys Arg Asp Val Asp Glu His Leu Arg Ile 
                85                  90                  95      


Lys Thr Val Tyr Asp Lys Ser Val Glu Glu Leu Leu Pro Glu Lys Lys 
            100                 105                 110         


Asn Leu Val Lys Asn Lys Leu Phe Pro Gln Ala Ile Ser Tyr Leu Glu 
        115                 120                 125             


Lys Thr Phe Gln Val Arg Arg Pro Ala Gly Thr Ile Leu Leu Ser Arg 
    130                 135                 140                 


Gln Cys Ala Thr Asn Gln Tyr Leu Arg Lys Glu Asn Asp Pro His Arg 
145                 150                 155                 160 


Tyr Cys Thr Gly Glu Cys Ala Ala His Thr Lys Cys Gly Pro Val Ile 
                165                 170                 175     


Val Pro Glu Glu His Leu Gln Gln Cys Arg Val Tyr Arg Gly Gly Lys 
            180                 185                 190         


Trp Pro His Gly Ala Val Gly Val Pro Asp Gln Glu Gly Ile Ser Asp 
        195                 200                 205             


Ala Asp Phe Val Leu Tyr Val Gly Ala Leu Ala Thr Glu Arg Cys Ser 
    210                 215                 220                 


His Glu Asn Ile Ile Ser Tyr Ala Ala Tyr Cys Gln Gln Glu Ala Asn 
225                 230                 235                 240 


Met Asp Arg Pro Ile Ala Gly Tyr Ala Asn Leu Cys Pro Asn Met Ile 
                245                 250                 255     


Ser Thr Gln Pro Gln Glu Phe Val Gly Met Leu Ser Thr Val Lys His 
            260                 265                 270         


Glu Val Ile His Ala Leu Gly Phe Ser Ala Gly Leu Phe Ala Phe Tyr 
        275                 280                 285             


His Asp Lys Asp Gly Asn Pro Leu Thr Ser Arg Phe Ala Asp Gly Leu 
    290                 295                 300                 


Pro Pro Phe Asn Tyr Ser Leu Gly Leu Tyr Gln Trp Ser Asp Lys Val 
305                 310                 315                 320 


Val Arg Lys Val Glu Arg Leu Trp Asp Val Arg Asp Asn Lys Ile Val 
                325                 330                 335     


Arg His Thr Val Tyr Leu Leu Val Thr Pro Arg Val Val Glu Glu Ala 
            340                 345                 350         


Arg Lys His Phe Asp Cys Pro Val Leu Glu Gly Met Glu Leu Glu Asn 
        355                 360                 365             


Gln Gly Gly Val Gly Thr Glu Leu Asn His Trp Glu Lys Arg Leu Leu 
    370                 375                 380                 


Glu Asn Glu Ala Met Thr Gly Ser His Thr Gln Asn Arg Val Leu Ser 
385                 390                 395                 400 


Arg Ile Thr Leu Ala Leu Met Glu Asp Thr Gly Trp Tyr Lys Ala Asn 
                405                 410                 415     


Tyr Ser Met Ala Glu Lys Leu Asp Trp Gly Arg Gly Met Gly Cys Asp 
            420                 425                 430         


Phe Val Arg Lys Ser Cys Lys Phe Trp Ile Asp Gln Gln Arg Gln Lys 
        435                 440                 445             


Arg Gln Met Leu Ser Pro Tyr Cys Asp Thr Leu Arg Ser Asn Pro Leu 
    450                 455                 460                 


Gln Leu Thr Cys Arg Gln Asp Gln Arg Ala Val Ala Val Cys Asn Leu 
465                 470                 475                 480 


Gln Lys Phe Pro Lys Pro Leu Pro Gln Glu Tyr Gln Tyr Phe Asp Glu 
                485                 490                 495     


Leu Ser Gly Ile Pro Ala Glu Asp Leu Pro Tyr Tyr Gly Gly Ser Val 
            500                 505                 510         


Glu Ile Ala Asp Tyr Cys Pro Phe Ser Gln Glu Phe Ser Trp His Leu 
        515                 520                 525             


Ser Gly Glu Tyr Gln Arg Ser Ser Asp Cys Arg Ile Leu Glu Asn Gln 
    530                 535                 540                 


Pro Glu Ile Phe Lys Asn Tyr Gly Ala Glu Lys Tyr Gly Pro His Ser 
545                 550                 555                 560 


Val Cys Leu Ile Gln Lys Ser Ala Phe Val Met Glu Lys Cys Glu Arg 
                565                 570                 575     


Lys Leu Ser Tyr Pro Asp Trp Gly Ser Gly Cys Tyr Gln Val Ser Cys 
            580                 585                 590         


Ser Pro Gln Gly Leu Lys Val Trp Val Gln Asp Thr Ser Tyr Leu Cys 
        595                 600                 605             


Ser Arg Ala Gly Gln Val Leu Pro Val Ser Ile Gln Met Asn Gly Trp 
    610                 615                 620                 


Ile His Asp Gly Asn Leu Leu Cys Pro Ser Cys Trp Asp Phe Cys Glu 
625                 630                 635                 640 


Leu Cys Pro Pro Glu Thr Asp Pro Pro Ala Thr Asn Leu Thr Arg Ala 
                645                 650                 655     


Leu Pro Leu Asp Leu Cys Ser Cys Ser Ser Ser Leu Val Val Thr Leu 
            660                 665                 670         


Trp Leu Leu Leu Gly Asn Leu Phe Pro Leu Leu Ala Gly Phe Leu Leu 
        675                 680                 685             


Cys Ile Trp His 
    690         


<210> 7411
<211> 1006
<212> PRT
<213> Homo sapiens

<400> 7411
Met Asp Ser Ser Gln Gln Lys Thr Phe Arg Gly His Asp Ala Pro Val 
1               5                   10                  15      


Leu Ser Leu Ser Phe Asp Pro Lys Asp Ile Phe Leu Ala Ser Ala Ser 
            20                  25                  30          


Cys Asp Gly Ser Val Arg Val Trp Gln Ile Ser Asp Gln Thr Cys Ala 
        35                  40                  45              


Ile Ser Trp Pro Leu Leu Gln Lys Cys Asn Asp Val Ile Asn Ala Lys 
    50                  55                  60                  


Ser Ile Cys Arg Leu Ala Trp Gln Pro Lys Ser Gly Lys Leu Leu Ala 
65                  70                  75                  80  


Ile Pro Val Glu Lys Ser Val Lys Leu Tyr Arg Arg Glu Ser Trp Ser 
                85                  90                  95      


His Gln Phe Asp Leu Ser Asp Asn Phe Ile Ser Gln Thr Leu Asn Ile 
            100                 105                 110         


Val Thr Trp Ser Pro Cys Gly Gln Tyr Leu Ala Ala Gly Ser Ile Asn 
        115                 120                 125             


Gly Leu Ile Ile Val Trp Asn Val Glu Thr Lys Asp Cys Met Glu Arg 
    130                 135                 140                 


Val Lys His Glu Lys Gly Tyr Ala Ile Cys Gly Leu Ala Trp His Pro 
145                 150                 155                 160 


Thr Cys Gly Arg Ile Ser Tyr Thr Asp Ala Glu Gly Asn Leu Gly Leu 
                165                 170                 175     


Leu Glu Asn Val Cys Asp Pro Ser Gly Lys Thr Ser Ser Ser Lys Val 
            180                 185                 190         


Ser Ser Arg Val Glu Lys Asp Tyr Asn Asp Leu Phe Asp Gly Asp Asp 
        195                 200                 205             


Met Ser Asn Ala Gly Asp Phe Leu Asn Asp Asn Ala Val Glu Ile Pro 
    210                 215                 220                 


Ser Phe Ser Lys Gly Ile Ile Asn Asp Asp Glu Asp Asp Glu Asp Leu 
225                 230                 235                 240 


Met Met Ala Ser Gly Arg Pro Arg Gln Arg Ser His Ile Leu Glu Asp 
                245                 250                 255     


Asp Glu Asn Ser Val Asp Ile Ser Met Leu Lys Thr Gly Ser Ser Leu 
            260                 265                 270         


Leu Lys Glu Glu Glu Glu Asp Gly Gln Glu Gly Ser Ile His Asn Leu 
        275                 280                 285             


Pro Leu Val Thr Ser Gln Arg Pro Phe Tyr Asp Gly Pro Met Pro Thr 
    290                 295                 300                 


Pro Arg Gln Lys Pro Phe Gln Ser Gly Ser Thr Pro Leu His Leu Thr 
305                 310                 315                 320 


His Arg Phe Met Val Trp Asn Ser Ile Gly Ile Ile Arg Cys Tyr Asn 
                325                 330                 335     


Asp Glu Gln Asp Asn Ala Ile Asp Val Glu Phe His Asp Thr Ser Ile 
            340                 345                 350         


His His Ala Thr His Leu Ser Asn Thr Leu Asn Tyr Thr Ile Ala Asp 
        355                 360                 365             


Leu Ser His Glu Ala Ile Leu Leu Ala Cys Glu Ser Thr Asp Glu Leu 
    370                 375                 380                 


Ala Ser Lys Leu His Cys Leu His Phe Ser Ser Trp Asp Ser Ser Lys 
385                 390                 395                 400 


Glu Trp Ile Ile Asp Leu Pro Gln Asn Glu Asp Ile Glu Ala Ile Cys 
                405                 410                 415     


Leu Gly Gln Gly Trp Ala Ala Ala Ala Thr Ser Ala Leu Leu Leu Arg 
            420                 425                 430         


Leu Phe Thr Ile Gly Gly Val Gln Lys Glu Val Phe Ser Leu Ala Gly 
        435                 440                 445             


Pro Val Val Ser Met Ala Gly His Gly Glu Gln Leu Phe Ile Val Tyr 
    450                 455                 460                 


His Arg Gly Thr Gly Phe Asp Gly Asp Gln Cys Leu Gly Val Gln Leu 
465                 470                 475                 480 


Leu Glu Leu Gly Lys Lys Lys Lys Gln Ile Leu His Gly Asp Pro Leu 
                485                 490                 495     


Pro Leu Thr Arg Lys Ser Tyr Leu Ala Trp Ile Gly Phe Ser Ala Glu 
            500                 505                 510         


Gly Thr Pro Cys Tyr Val Asp Ser Glu Gly Ile Val Arg Met Leu Asn 
        515                 520                 525             


Arg Gly Leu Gly Asn Thr Trp Thr Pro Ile Cys Asn Thr Arg Glu His 
    530                 535                 540                 


Cys Lys Gly Lys Ser Asp His Tyr Trp Val Val Gly Ile His Glu Asn 
545                 550                 555                 560 


Pro Gln Gln Leu Arg Cys Ile Pro Cys Lys Gly Ser Arg Phe Pro Pro 
                565                 570                 575     


Thr Leu Pro Arg Pro Ala Val Ala Ile Leu Ser Phe Lys Leu Pro Tyr 
            580                 585                 590         


Cys Gln Ile Ala Thr Glu Lys Gly Gln Met Glu Glu Gln Phe Trp Arg 
        595                 600                 605             


Ser Val Ile Phe His Asn His Leu Asp Tyr Leu Ala Lys Asn Gly Tyr 
    610                 615                 620                 


Glu Tyr Glu Glu Ser Thr Lys Asn Gln Ala Thr Lys Glu Gln Gln Glu 
625                 630                 635                 640 


Leu Leu Met Lys Met Leu Ala Leu Ser Cys Lys Leu Glu Arg Glu Phe 
                645                 650                 655     


Arg Cys Val Glu Leu Ala Asp Leu Met Thr Gln Asn Ala Val Asn Leu 
            660                 665                 670         


Ala Ile Lys Tyr Ala Ser Arg Ser Arg Lys Leu Ile Leu Ala Gln Lys 
        675                 680                 685             


Leu Ser Glu Leu Ala Val Glu Lys Ala Ala Glu Leu Thr Ala Thr Gln 
    690                 695                 700                 


Val Glu Glu Glu Glu Glu Glu Glu Asp Phe Arg Lys Lys Leu Asn Ala 
705                 710                 715                 720 


Gly Tyr Ser Asn Thr Ala Thr Glu Trp Ser Gln Pro Arg Phe Arg Asn 
                725                 730                 735     


Gln Val Glu Glu Asp Ala Glu Asp Ser Gly Glu Ala Asp Asp Glu Glu 
            740                 745                 750         


Lys Pro Glu Ile His Lys Pro Gly Gln Asn Ser Phe Ser Lys Ser Thr 
        755                 760                 765             


Asn Ser Ser Asp Val Ser Ala Lys Ser Gly Ala Val Thr Phe Ser Ser 
    770                 775                 780                 


Gln Gly Arg Val Asn Pro Phe Lys Val Ser Ala Ser Ser Lys Glu Pro 
785                 790                 795                 800 


Ala Met Ser Met Asn Ser Ala Arg Ser Thr Asn Ile Leu Asp Asn Met 
                805                 810                 815     


Gly Lys Ser Ser Lys Lys Ser Thr Ala Leu Ser Arg Thr Thr Asn Asn 
            820                 825                 830         


Glu Lys Ser Pro Ile Ile Lys Pro Leu Ile Pro Lys Pro Lys Pro Lys 
        835                 840                 845             


Gln Ala Ser Ala Ala Ser Tyr Phe Gln Lys Arg Asn Ser Gln Thr Asn 
    850                 855                 860                 


Lys Thr Glu Glu Val Lys Glu Glu Asn Leu Lys Asn Val Leu Ser Glu 
865                 870                 875                 880 


Thr Pro Ala Ile Cys Pro Pro Gln Asn Thr Glu Asn Gln Arg Pro Lys 
                885                 890                 895     


Thr Gly Phe Gln Met Trp Leu Glu Glu Asn Arg Ser Asn Ile Leu Ser 
            900                 905                 910         


Asp Asn Pro Asp Phe Ser Asp Glu Ala Asp Ile Ile Lys Glu Gly Met 
        915                 920                 925             


Ile Arg Phe Arg Val Leu Ser Thr Glu Glu Arg Lys Val Trp Ala Asn 
    930                 935                 940                 


Lys Ala Lys Gly Glu Thr Ala Ser Glu Gly Thr Glu Ala Lys Lys Arg 
945                 950                 955                 960 


Lys Arg Val Val Asp Glu Ser Asp Glu Thr Glu Asn Gln Glu Glu Lys 
                965                 970                 975     


Ala Lys Glu Asn Leu Asn Leu Ser Lys Lys Gln Lys Pro Leu Asp Phe 
            980                 985                 990         


Ser Thr Asn Gln Lys Leu Ser Ala  Phe Ala Phe Lys Gln  Glu 
        995                 1000                 1005     


<210> 7412
<211> 179
<212> PRT
<213> Homo sapiens

<400> 7412
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn 
145                 150                 155                 160 


Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Glu Gly Ile 
                165                 170                 175     


Asn Val Gly 
            


<210> 7413
<211> 1062
<212> PRT
<213> Homo sapiens

<400> 7413
Met Ile Ser Lys Gly Gly Ser Glu Ala Leu Leu Gln Thr Leu Val Asp 
1               5                   10                  15      


Thr Ala Arg Thr Ala Pro Pro Asp Tyr Asp Ile Leu Leu Pro Leu Phe 
            20                  25                  30          


Arg Leu Leu Ala Lys Val Gly Leu Arg Asp Lys Lys Ile Gly Arg Lys 
        35                  40                  45              


Ala Leu Glu Leu Glu Ala Leu Asp Val Thr Leu Ile Leu Ala Arg Lys 
    50                  55                  60                  


Asn Leu Ser His Gly Gln Asn Leu Leu His Cys Leu Trp Ala Leu Arg 
65                  70                  75                  80  


Val Phe Ala Ser Ser Val Ser Met Gly Ala Met Leu Gly Ile Asn Gly 
                85                  90                  95      


Ala Met Glu Leu Leu Phe Lys Val Ile Thr Pro Tyr Thr Arg Lys Arg 
            100                 105                 110         


Thr Gln Ala Ile Arg Ala Ala Thr Glu Val Leu Ala Ala Leu Leu Lys 
        115                 120                 125             


Ser Lys Ser Asn Gly Arg Arg Ala Val Asn Arg Gly Tyr Val Thr Ser 
    130                 135                 140                 


Leu Leu Gly Leu His Gln Asp Trp His Ser His Asp Thr Ala Asn Ala 
145                 150                 155                 160 


Tyr Val Gln Ile Arg Arg Gly Leu Leu Leu Cys Leu Arg His Ile Ala 
                165                 170                 175     


Ala Leu Arg Ser Gly Arg Glu Ala Phe Leu Ala Ala Gln Gly Met Glu 
            180                 185                 190         


Ile Leu Phe Ser Thr Thr Gln Asn Cys Leu Asp Asp Lys Ser Met Glu 
        195                 200                 205             


Pro Val Ile Ser Val Val Leu Gln Ile Leu Arg Gln Cys Tyr Pro Thr 
    210                 215                 220                 


Ser Pro Leu Pro Leu Val Thr Ala Ser Ser Ala Tyr Ala Phe Pro Val 
225                 230                 235                 240 


Pro Gly Cys Ile Thr Thr Glu Pro Pro His Asp Leu Pro Glu Glu Asp 
                245                 250                 255     


Phe Glu Asp Asp Gly Asp Asp Glu Val Asp Lys Asp Ser Asp Thr Glu 
            260                 265                 270         


Asp Gly Lys Val Glu Asp Asp Asp Leu Glu Thr Asp Val Asn Lys Leu 
        275                 280                 285             


Ser Ser Lys Pro Gly Leu Asp Arg Pro Glu Glu Glu Leu Met Gln Tyr 
    290                 295                 300                 


Glu Val Met Cys Leu Glu Leu Ser Tyr Ser Phe Glu Glu Leu Gln Ser 
305                 310                 315                 320 


Lys Leu Gly Asp Asp Leu Asn Ser Glu Lys Thr Gln Tyr Ala Asn His 
                325                 330                 335     


His His Ile Pro Ala Ala Ala Ser Ser Lys Gln His Cys Tyr Ser Lys 
            340                 345                 350         


Asp Gln Ser Ser Cys Gly Gln Glu Arg Glu Tyr Ala Val Gln Thr Ser 
        355                 360                 365             


Leu Leu Cys Arg Val Lys Thr Gly Arg Ser Thr Val His Leu Gly Ser 
    370                 375                 380                 


Lys Lys Asn Pro Gly Val Asn Leu Tyr Gln Asn Val Gln Ser Asn Ser 
385                 390                 395                 400 


Leu Arg Arg Asp Ser Ser Glu Ser Glu Ile Pro Asp Ile Gln Ala Ser 
                405                 410                 415     


Pro Lys Ala Asp Ala Trp Asp Val Asp Ala Ile Phe Cys Pro Arg Met 
            420                 425                 430         


Ser Ala Ser Phe Ser Asn Ser Thr Arg Thr Arg Glu Val Val Lys Val 
        435                 440                 445             


Ile Asp Lys Leu Leu Gln Thr His Leu Lys Arg Val Pro Phe His Asp 
    450                 455                 460                 


Pro Tyr Leu Tyr Met Ala Lys Ala Arg Arg Thr Ser Ser Val Val Asp 
465                 470                 475                 480 


Phe Lys Met Met Ala Phe Pro Asp Val Trp Gly His Cys Pro Pro Pro 
                485                 490                 495     


Thr Thr Gln Pro Met Leu Glu Arg Lys Cys Gly Val Gln Arg Ile Arg 
            500                 505                 510         


Ile Phe Glu Asp Ile Arg Arg Leu Ile Gln Pro Ser Asp Val Ile Asn 
        515                 520                 525             


Lys Val Val Phe Ser Leu Asp Glu Pro Trp Pro Leu Gln Asp Asn Ala 
    530                 535                 540                 


Ser Asn Cys Leu Arg Phe Phe Ser Lys Phe Glu Ser Gly Asn Leu Arg 
545                 550                 555                 560 


Lys Ala Ile Gln Val Arg Glu Phe Glu Tyr Asp Leu Leu Val Asn Ala 
                565                 570                 575     


Asp Val Asn Ser Thr Gln His Gln Gln Trp Phe Tyr Phe Lys Val Ser 
            580                 585                 590         


Gly Met Gln Ala Ala Ile Pro Tyr His Phe Asn Ile Ile Asn Cys Glu 
        595                 600                 605             


Lys Pro Asn Ser Gln Phe Asn Tyr Gly Met Gln Pro Thr Leu Tyr Ser 
    610                 615                 620                 


Val Lys Glu Ala Leu Leu Gly Lys Pro Thr Trp Ile Arg Thr Gly His 
625                 630                 635                 640 


Glu Ile Cys Tyr Tyr Lys Asn His Tyr Arg Gln Ser Thr Ala Val Ala 
                645                 650                 655     


Gly Gly Ala Ser Gly Lys Cys Tyr Tyr Thr Leu Thr Phe Ala Val Thr 
            660                 665                 670         


Phe Pro His Ser Glu Asp Val Cys Tyr Leu Ala Tyr His Tyr Pro Tyr 
        675                 680                 685             


Thr Tyr Thr Ala Leu Met Thr His Leu Asp Ile Leu Glu Lys Ser Val 
    690                 695                 700                 


Asn Leu Lys Glu Val Tyr Phe Arg Gln Asp Val Leu Cys Gln Thr Leu 
705                 710                 715                 720 


Gly Gly Asn Pro Cys Pro Leu Val Thr Ile Thr Ala Met Pro Glu Ser 
                725                 730                 735     


Asn Ser Asp Glu His Leu Glu Gln Phe Arg His Arg Pro Tyr Gln Val 
            740                 745                 750         


Ile Thr Ala Arg Val His Pro Gly Glu Ser Asn Ala Ser Trp Val Met 
        755                 760                 765             


Lys Gly Thr Leu Glu Phe Leu Val Ser Ser Asp Pro Val Ala Arg Leu 
    770                 775                 780                 


Leu Arg Glu Asn Phe Ile Phe Lys Ile Ile Pro Met Leu Asn Pro Asp 
785                 790                 795                 800 


Gly Val Ile Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu Asp Leu 
                805                 810                 815     


Asn Arg Gln Trp Leu Ser Pro Ser Ala His Leu Gln Pro Thr Ile Tyr 
            820                 825                 830         


His Ala Lys Gly Leu Leu Tyr His Leu Ser Ser Ile Gly Arg Ser Pro 
        835                 840                 845             


Val Val Phe Cys Asp Phe His Gly His Ser Gln Lys Lys Asn Val Phe 
    850                 855                 860                 


Leu Tyr Gly Cys Ser Ile Lys Glu Thr Leu Trp Gln Ala Ala Cys Thr 
865                 870                 875                 880 


Val Gly Thr Ser Thr Ile Leu Glu Glu Val Asn Tyr Arg Thr Leu Pro 
                885                 890                 895     


Lys Ile Leu Asp Lys Leu Ala Pro Ala Phe Thr Met Ser Ser Cys Ser 
            900                 905                 910         


Phe Leu Val Glu Lys Ser Arg Ala Ser Thr Ala Arg Val Val Val Trp 
        915                 920                 925             


Arg Glu Met Gly Val Ser Arg Ser Tyr Thr Met Glu Ser Ser Tyr Cys 
    930                 935                 940                 


Gly Cys Asn Gln Gly Pro Tyr Gln Cys Thr Gln Arg Leu Leu Glu Arg 
945                 950                 955                 960 


Thr Lys Asn Glu Arg Ala His Pro Val Asp Gly Leu Gln Gly Leu Gln 
                965                 970                 975     


Phe Gly Thr Arg Glu Leu Glu Glu Met Gly Ala Met Phe Cys Leu Gly 
            980                 985                 990         


Leu Leu Ile Leu Glu Leu Lys Ser  Ala Ser Cys Ser His  Gln Leu Leu 
        995                 1000                 1005             


Ala Gln  Ala Ala Thr Leu Leu  Ser Ala Glu Glu Asp  Ala Leu Asp 
    1010                 1015                 1020             


Gln His  Leu Gln Arg Leu Lys  Ser Ser Asn Phe Leu  Pro Lys His 
    1025                 1030                 1035             


Ile Trp  Phe Ala Tyr His Phe  Phe Ala Ile Thr Asn  Phe Phe Lys 
    1040                 1045                 1050             


Met Asn  Leu Leu Leu His Val  Ser Pro 
    1055                 1060         


<210> 7414
<211> 245
<212> PRT
<213> Homo sapiens

<400> 7414
Met Ala Ala Ala Pro Pro Ser Tyr Cys Phe Val Ala Phe Pro Pro Arg 
1               5                   10                  15      


Ala Lys Asp Gly Leu Val Val Phe Gly Lys Asn Ser Ala Arg Pro Arg 
            20                  25                  30          


Asp Glu Val Gln Glu Val Val Tyr Phe Ser Ala Ala Asp His Glu Pro 
        35                  40                  45              


Glu Ser Lys Val Glu Cys Thr Tyr Ile Ser Ile Asp Gln Val Pro Arg 
    50                  55                  60                  


Thr Tyr Ala Ile Met Ile Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Ala Asn Glu Ala Ile Asn 
                85                  90                  95      


Thr Arg Glu Pro Ala Ala Glu Ile Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Gly Glu Thr Ala Lys Glu Ala Leu Asp 
        115                 120                 125             


Val Ile Val Ser Leu Leu Glu Glu His Gly Gln Gly Gly Asn Tyr Phe 
    130                 135                 140                 


Glu Asp Ala Asn Ser Cys His Ser Phe Gln Ser Ala Tyr Leu Ile Val 
145                 150                 155                 160 


Asp Arg Asp Glu Ala Trp Val Leu Glu Thr Ile Gly Lys Tyr Trp Ala 
                165                 170                 175     


Ala Glu Lys Val Thr Glu Gly Val Arg Cys Ile Cys Ser Gln Leu Ser 
            180                 185                 190         


Leu Thr Thr Lys Met Asp Ala Glu His Pro Glu Leu Arg Ser Tyr Ala 
        195                 200                 205             


Gln Ser Gln Gly Trp Trp Thr Gly Glu Gly Glu Phe Asn Phe Ser Glu 
    210                 215                 220                 


Val Phe Ser Pro Val Glu Asp His Leu Asp Cys Gly Ala Gly Lys Asp 
225                 230                 235                 240 


Ser Leu Glu Lys Gln 
                245 


<210> 7415
<211> 32
<212> PRT
<213> Homo sapiens

<400> 7415
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


<210> 7416
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7416
Xaa Val Leu Gly Ser Pro Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile 
1               5                   10                  15      


Gln Pro Gly Thr Thr Val Leu Asn Cys Ser His Asp Phe Leu Ser Glu 
            20                  25                  30          


Ser Leu Ile Ile Ile Arg Arg Met Ala Ile Phe 
        35                  40              


<210> 7417
<211> 112
<212> PRT
<213> Homo sapiens

<400> 7417
Met Phe Ala Lys Leu Lys Lys Lys Ile Ala Glu Glu Thr Ala Val Ala 
1               5                   10                  15      


Gln Arg Pro Gly Gly Ala Thr Arg Ile Pro Arg Ser Val Ser Lys Glu 
            20                  25                  30          


Ser Val Ala Ser Met Gly Ala Asp Ser Gly Asp Asp Phe Ala Ser Asp 
        35                  40                  45              


Gly Ser Ser Ser Arg Glu Asp Leu Ser Ser Gln Leu Leu Arg Arg Asn 
    50                  55                  60                  


Glu Gln Ile Arg Lys Leu Glu Ala Arg Leu Ser Asp Tyr Ala Glu Gln 
65                  70                  75                  80  


Val Arg Asn Leu Gln Lys Ile Lys Glu Lys Leu Glu Ile Ala Leu Glu 
                85                  90                  95      


Lys His Gln Asp Ser Ser Met Arg Lys Phe Gln Glu Gln Asn Glu Thr 
            100                 105                 110         


<210> 7418
<211> 192
<212> PRT
<213> Homo sapiens

<400> 7418
Met Gly Lys Gly Cys Lys Val Val Val Cys Gly Leu Leu Ser Val Gly 
1               5                   10                  15      


Lys Thr Ala Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Thr Ile Gly 
            20                  25                  30          


Met Glu Asp Cys Glu Thr Met Glu Asp Val Tyr Met Ala Ser Val Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Lys Glu Gln Leu His Leu Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Gln Glu Gly Val Glu Leu Pro Lys His Tyr Phe Ser Phe Ala Asp 
65                  70                  75                  80  


Gly Phe Val Leu Val Tyr Ser Val Asn Asn Leu Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Phe Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Ala Ile Val Val Leu Gly Asn Lys Ile Asp Leu Ser Glu Gln Arg 
        115                 120                 125             


Gln Val Asp Ala Glu Val Ala Gln Gln Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Arg Leu Trp Glu Val Thr Val Thr Asp Arg Lys Thr Leu Ile Glu Pro 
145                 150                 155                 160 


Phe Thr Leu Leu Ala Ser Lys Leu Ser Gln Pro Gln Ser Lys Ser Ser 
                165                 170                 175     


Phe Pro Leu Pro Gly Arg Lys Asn Lys Gly Asn Ser Asn Ser Glu Asn 
            180                 185                 190         


<210> 7419
<211> 485
<212> PRT
<213> Homo sapiens

<400> 7419
Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Gly Leu 
                485 


<210> 7420
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7420
Met Asp Val Leu Ser Pro Leu Ser Phe Ile Lys Val Ser His Val Arg 
1               5                   10                  15      


Met Gln Gly Ile Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro 
            20                  25                  30          


Tyr Ile Gln Ile Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly 
        35                  40                  45              


Tyr Trp Gly Asn Lys Gly Gly Val Asn Ile Cys Leu Lys Leu Tyr Gly 
    50                  55                  60                  


Tyr Tyr Val Ser Ile Ile Asn Cys His Leu Pro Pro His Ile Ser Asn 
65                  70                  75                  80  


Asn Tyr Gln Arg Leu Glu His Phe Asp Arg Ile Leu Glu Met Gln Asn 
                85                  90                  95      


Cys Glu Gly Arg Asp Ile Pro Asn Ile Leu Asp His Asp Leu Ile Ile 
            100                 105                 110         


Trp Phe Gly Asp Met Asn Phe Arg Ile Glu Asp Phe Gly Leu His Phe 
        115                 120                 125             


Val Arg Glu Ser Ile Lys Asn Arg Cys Tyr Gly Gly Leu Trp Glu Lys 
    130                 135                 140                 


Asp Gln Leu Ser Ile Ala Lys Lys His Asp Pro Leu Leu Arg Glu Phe 
145                 150                 155                 160 


Gln Glu Gly Arg Leu Leu Phe Pro Pro Thr Tyr Lys Phe Asp Arg Asn 
                165                 170                 175     


Ser Asn Asp Tyr Asp Thr Ser Glu Lys Lys Arg Lys Pro Ala Trp Thr 
            180                 185                 190         


Asp Arg Ile Leu Trp Arg Leu Lys Arg Gln Pro Cys Ala Gly Pro Asp 
        195                 200                 205             


Thr Pro Ile Pro Pro Ala Ser His Phe Ser Leu Ser Leu Arg Gly Tyr 
    210                 215                 220                 


Ser Ser His Met Thr Tyr Gly Ile Ser Asp His Lys Pro Val Ser Gly 
225                 230                 235                 240 


Thr Phe Asp Leu Glu Leu Lys Pro Leu Val Ser Ala Pro Leu Ile Val 
                245                 250                 255     


Leu Met Pro Glu Asp Leu Trp Thr Val Glu Asn Asp Met Met Val Ser 
            260                 265                 270         


Tyr Ser Ser Thr Ser Asp Phe Pro Ser Ser Pro Trp Asp Trp Ile Gly 
        275                 280                 285             


Leu Tyr Lys Val Gly Leu Arg Asp Val Asn Asp Tyr Val Ser Tyr Ala 
    290                 295                 300                 


Trp Val Gly Asp Ser Lys Val Ser Cys Ser Asp Asn Leu Asn Gln Val 
305                 310                 315                 320 


Tyr Ile Asp Ile Ser Asn Ile Pro Thr Thr Glu Asp Glu Phe Leu Leu 
                325                 330                 335     


Cys Tyr Tyr Ser Asn Ser Leu Arg Ser Val Val Gly Ile Ser Arg Pro 
            340                 345                 350         


Phe Gln Ile Pro Pro Gly Ser Leu Arg Glu Asp Pro Leu Gly Glu Ala 
        355                 360                 365             


Gln Pro Gln Ile 
    370         


<210> 7421
<211> 515
<212> PRT
<213> Homo sapiens

<400> 7421
Met Ser Glu Gly Glu Ser Gln Thr Ser Val Ser Pro Pro Val Thr Ser 
1               5                   10                  15      


Thr Thr Ser Ala Ala Ser Pro Glu Glu Glu Glu Glu Ser Glu Asp Glu 
            20                  25                  30          


Ser Glu Ile Leu Glu Glu Ser Pro Cys Gly Arg Trp Gln Lys Arg Arg 
        35                  40                  45              


Glu Glu Val Asn Gln Arg Asn Val Pro Gly Ile Asp Ser Ala Tyr Leu 
    50                  55                  60                  


Ala Met Asp Thr Glu Glu Gly Val Glu Val Val Trp Asn Glu Val Gln 
65                  70                  75                  80  


Phe Ser Glu Arg Lys Asn Tyr Lys Leu Gln Glu Glu Lys Val Arg Ala 
                85                  90                  95      


Val Phe Asp Asn Leu Ile Gln Leu Glu His Leu Asn Ile Val Lys Phe 
            100                 105                 110         


His Lys Tyr Trp Ala Asp Ile Lys Glu Asn Lys Ala Arg Val Ile Phe 
        115                 120                 125             


Ile Thr Glu Tyr Met Ser Ser Gly Ser Leu Lys Gln Phe Leu Lys Lys 
    130                 135                 140                 


Thr Lys Lys Asn His Lys Thr Met Asn Glu Lys Ala Trp Lys Arg Trp 
145                 150                 155                 160 


Cys Thr Gln Ile Leu Ser Ala Leu Ser Tyr Leu His Ser Cys Asp Pro 
                165                 170                 175     


Pro Ile Ile His Gly Asn Leu Thr Cys Asp Thr Ile Phe Ile Gln His 
            180                 185                 190         


Asn Gly Leu Ile Lys Ile Gly Ser Val Ala Pro Asp Thr Ile Asn Asn 
        195                 200                 205             


His Val Lys Thr Cys Arg Glu Glu Gln Lys Asn Leu His Phe Phe Ala 
    210                 215                 220                 


Pro Glu Tyr Gly Glu Val Thr Asn Val Thr Thr Ala Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Phe Gly Met Cys Ala Leu Glu Met Ala Val Leu Glu Ile Gln Gly 
                245                 250                 255     


Asn Gly Glu Ser Ser Tyr Val Pro Gln Glu Ala Ile Ser Ser Ala Ile 
            260                 265                 270         


Gln Leu Leu Glu Asp Pro Leu Gln Arg Glu Phe Ile Gln Lys Cys Leu 
        275                 280                 285             


Gln Ser Glu Pro Ala Arg Arg Pro Thr Ala Arg Glu Leu Leu Phe His 
    290                 295                 300                 


Pro Ala Leu Phe Glu Val Pro Ser Leu Lys Leu Leu Ala Ala His Cys 
305                 310                 315                 320 


Ile Val Gly His Gln His Met Ile Pro Glu Asn Ala Leu Glu Glu Ile 
                325                 330                 335     


Thr Lys Asn Met Asp Thr Ser Ala Val Leu Ala Glu Ile Pro Ala Gly 
            340                 345                 350         


Pro Gly Arg Glu Pro Val Gln Thr Leu Tyr Ser Gln Ser Pro Ala Leu 
        355                 360                 365             


Glu Leu Asp Lys Phe Leu Glu Asp Val Arg Asn Gly Ile Tyr Pro Leu 
    370                 375                 380                 


Thr Ala Phe Gly Leu Pro Arg Pro Gln Gln Pro Gln Gln Glu Glu Val 
385                 390                 395                 400 


Thr Ser Pro Val Val Pro Pro Ser Val Lys Thr Pro Thr Pro Glu Pro 
                405                 410                 415     


Ala Glu Val Glu Thr Arg Lys Val Val Leu Met Gln Cys Asn Ile Glu 
            420                 425                 430         


Ser Val Glu Glu Gly Val Lys His His Leu Thr Leu Leu Leu Lys Leu 
        435                 440                 445             


Glu Asp Lys Leu Asn Arg His Leu Ser Cys Asp Leu Met Pro Asn Glu 
    450                 455                 460                 


Asn Ile Pro Glu Leu Ala Ala Glu Leu Val Gln Leu Gly Phe Ile Ser 
465                 470                 475                 480 


Glu Ala Asp Gln Ser Arg Leu Thr Ser Leu Leu Glu Glu Thr Leu Asn 
                485                 490                 495     


Lys Phe Asn Phe Ala Arg Asn Ser Thr Leu Asn Ser Ala Ala Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210> 7422
<211> 144
<212> PRT
<213> Homo sapiens

<400> 7422
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr 
65                  70                  75                  80  


Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu 
                85                  90                  95      


Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln 
            100                 105                 110         


Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu 
        115                 120                 125             


Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu 
    130                 135                 140                 


<210> 7423
<211> 348
<212> PRT
<213> Homo sapiens

<400> 7423
Met Pro Ala Pro Pro Cys Ala Ser Cys His Ala Ala Arg Ala Ala Leu 
1               5                   10                  15      


Arg Arg Pro Leu Ser Gly Gln Ala Leu Cys Gly Ala Cys Phe Cys Ala 
            20                  25                  30          


Ala Phe Glu Ala Glu Val Leu His Thr Val Leu Ala Gly Arg Leu Leu 
        35                  40                  45              


Pro Pro Gly Ala Val Val Ala Val Gly Ala Ser Gly Gly Lys Asp Ser 
    50                  55                  60                  


Thr Val Leu Ala His Val Leu Arg Ala Leu Ala Pro Arg Leu Gly Ile 
65                  70                  75                  80  


Ser Leu Gln Leu Val Ala Val Asp Glu Gly Ile Gly Gly Tyr Arg Asp 
                85                  90                  95      


Ala Ala Leu Ala Ala Val Arg Arg Gln Ala Ala Arg Trp Glu Leu Pro 
            100                 105                 110         


Leu Thr Val Val Ala Tyr Glu Asp Leu Phe Gly Gly Trp Thr Met Asp 
        115                 120                 125             


Ala Val Ala Arg Ser Thr Ala Gly Ser Gly Arg Ser Arg Ser Cys Cys 
    130                 135                 140                 


Thr Phe Cys Gly Val Leu Arg Arg Arg Ala Leu Glu Glu Gly Ala Arg 
145                 150                 155                 160 


Arg Val Gly Ala Thr His Ile Val Thr Gly His Asn Ala Asp Asp Met 
                165                 170                 175     


Ala Glu Thr Val Leu Met Asn Phe Leu Arg Gly Asp Ala Gly Arg Leu 
            180                 185                 190         


Ala Arg Gly Gly Gly Leu Gly Ser Pro Gly Glu Gly Gly Ala Leu Pro 
        195                 200                 205             


Arg Cys Arg Pro Leu Gln Phe Ala Ser Gln Lys Glu Val Val Leu Tyr 
    210                 215                 220                 


Ala His Phe Arg Arg Leu Asp Tyr Phe Ser Glu Glu Cys Val Tyr Ala 
225                 230                 235                 240 


Pro Glu Ala Phe Arg Gly His Ala Arg Asp Leu Leu Lys Arg Leu Glu 
                245                 250                 255     


Ala Ala Arg Pro Ser Ala Val Leu Asp Leu Val His Ser Ala Glu Arg 
            260                 265                 270         


Leu Ala Leu Ala Pro Ala Ala Arg Pro Pro Arg Pro Gly Ala Cys Ser 
        275                 280                 285             


Arg Cys Gly Ala Leu Ala Ser Arg Ala Leu Cys Gln Ala Cys Ala Leu 
    290                 295                 300                 


Leu Asp Gly Leu Asn Arg Gly Arg Pro Arg Leu Ala Ile Gly Lys Gly 
305                 310                 315                 320 


Arg Arg Gly Leu Asp Glu Glu Ala Thr Pro Gly Thr Pro Gly Asp Pro 
                325                 330                 335     


Ala Arg Pro Pro Ala Ser Lys Ala Val Pro Thr Phe 
            340                 345             


<210> 7424
<211> 106
<212> PRT
<213> Homo sapiens

<400> 7424
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ser Asp Val Gln Thr Ala 
            100                 105     


<210> 7425
<211> 65
<212> PRT
<213> Homo sapiens

<400> 7425
Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser 
1               5                   10                  15      


Gly Asn Leu Ala His Val Glu Lys Val Glu Ser Leu Ser Ser Asp Gly 
            20                  25                  30          


Glu Gly Val Gly Gly Gly Ala Ser Ala Leu Thr Ser Gly Ile Ala Ser 
        35                  40                  45              


Ser Pro Asp Tyr Glu Phe Asn Val Trp Thr Arg Pro Asp Cys Ala Glu 
    50                  55                  60                  


Thr 
65  


<210> 7426
<211> 456
<212> PRT
<213> Homo sapiens

<400> 7426
Met Ala Asp Ser Leu Glu Ser Thr Pro Leu Pro Ser Pro Glu Asp Arg 
1               5                   10                  15      


Leu Ala Lys Leu His Pro Ser Lys Glu Leu Leu Glu Tyr Tyr Gln Lys 
            20                  25                  30          


Lys Met Ala Glu Cys Glu Ala Glu Asn Glu Asp Leu Leu Lys Lys Leu 
        35                  40                  45              


Glu Leu Tyr Lys Glu Ala Cys Glu Gly Gln His Lys Leu Glu Cys Asp 
    50                  55                  60                  


Leu Gln Gln Arg Glu Glu Glu Ile Ala Glu Leu Gln Lys Ala Leu Ser 
65                  70                  75                  80  


Asp Met Gln Val Cys Leu Phe Gln Glu Arg Glu His Val Leu Arg Leu 
                85                  90                  95      


Tyr Ser Glu Asn Asp Arg Leu Arg Ile Arg Glu Leu Glu Asp Lys Lys 
            100                 105                 110         


Lys Ile Gln Asn Leu Leu Ala Leu Val Gly Thr Asp Ala Gly Glu Val 
        115                 120                 125             


Thr Tyr Phe Cys Lys Glu Pro Pro His Lys Val Thr Ile Leu Gln Lys 
    130                 135                 140                 


Thr Ile Gln Ala Val Gly Glu Cys Glu Gln Ser Glu Ser Ser Ala Phe 
145                 150                 155                 160 


Lys Ala Asp Pro Lys Ile Ser Lys Arg Arg Pro Ser Arg Glu Arg Lys 
                165                 170                 175     


Glu Ser Ser Glu His Tyr Gln Arg Asp Ile Gln Thr Leu Ile Leu Gln 
            180                 185                 190         


Val Glu Ala Leu Gln Ala Gln Leu Gly Glu Gln Thr Lys Leu Ser Arg 
        195                 200                 205             


Glu Gln Ile Glu Gly Leu Ile Glu Asp Arg Arg Ile His Leu Glu Glu 
    210                 215                 220                 


Ile Gln Val Gln His Gln Arg Asn Gln Asn Lys Ile Lys Glu Leu Thr 
225                 230                 235                 240 


Lys Asn Leu His His Thr Gln Glu Leu Leu Tyr Glu Ser Thr Lys Asp 
                245                 250                 255     


Phe Leu Gln Leu Arg Ser Glu Asn Gln Asn Lys Glu Lys Ser Trp Met 
            260                 265                 270         


Leu Glu Lys Asp Asn Leu Met Ser Lys Ile Lys Gln Tyr Arg Val Gln 
        275                 280                 285             


Cys Lys Lys Lys Glu Asp Lys Ile Gly Lys Val Leu Pro Val Met His 
    290                 295                 300                 


Glu Ser His His Ala Gln Ser Glu Tyr Ile Lys Ser Leu Lys Asp Lys 
305                 310                 315                 320 


Leu Val Gln Glu Lys Lys Leu Ser Asn Met Tyr Gln Glu Gln Cys Ile 
                325                 330                 335     


Ser Leu Glu Glu Glu Leu Ala Arg Ile Arg Glu Glu Glu Gly Met Arg 
            340                 345                 350         


Arg Glu Ile Phe Lys Asp Arg Thr Asn Lys Met Gly Lys Arg Leu Gln 
        355                 360                 365             


Ile Met Thr Lys Arg Tyr Glu Ala Leu Glu Arg Arg Arg Ile Leu Glu 
    370                 375                 380                 


Val Glu Gly Phe Lys Thr Asp Ile Lys Val Leu Arg Gln Lys Leu Lys 
385                 390                 395                 400 


Asp Leu Glu Gln Met Leu Tyr Lys Ala Thr Val Asn Ala Arg Ala Asn 
                405                 410                 415     


Gln Asp Leu Ala Leu Leu Cys Glu Val Arg Asp Ser Asn Arg Arg Ala 
            420                 425                 430         


His Lys Ile Gln Gly Glu Leu Lys Asn Leu Lys Ser Lys Val Phe Gly 
        435                 440                 445             


Leu Glu Asn Glu Leu Arg Leu Cys 
    450                 455     


<210> 7427
<211> 424
<212> PRT
<213> Homo sapiens

<400> 7427
Met Asp Gln Pro Ser Gly Arg Ser Phe Met Gln Val Leu Cys Glu Lys 
1               5                   10                  15      


Tyr Ser Pro Glu Asn Phe Pro Tyr Arg Arg Gly Pro Gly Met Gly Val 
            20                  25                  30          


His Val Pro Ala Thr Pro Gln Gly Ser Pro Met Lys Asp Arg Leu Asn 
        35                  40                  45              


Leu Pro Ser Val Leu Val Leu Asn Ser Cys Gly Ile Thr Cys Ala Gly 
    50                  55                  60                  


Asp Glu Lys Glu Ile Ala Ala Phe Cys Ala His Val Ser Glu Leu Asp 
65                  70                  75                  80  


Leu Ser Asp Asn Lys Leu Glu Asp Trp His Glu Val Ser Lys Ile Val 
                85                  90                  95      


Ser Asn Val Pro Gln Leu Glu Phe Leu Asn Leu Ser Ser Asn Pro Leu 
            100                 105                 110         


Asn Leu Ser Val Leu Glu Arg Thr Cys Ala Gly Ser Phe Ser Gly Val 
        115                 120                 125             


Arg Lys Leu Val Leu Asn Asn Ser Lys Ala Ser Trp Glu Thr Val His 
    130                 135                 140                 


Met Ile Leu Gln Glu Leu Pro Asp Leu Glu Glu Leu Phe Leu Cys Leu 
145                 150                 155                 160 


Asn Asp Tyr Glu Thr Val Ser Cys Pro Ser Ile Cys Cys His Ser Leu 
                165                 170                 175     


Lys Leu Leu His Ile Thr Asp Asn Asn Leu Gln Asp Trp Thr Glu Ile 
            180                 185                 190         


Arg Lys Leu Gly Val Met Phe Pro Ser Leu Asp Thr Leu Val Leu Ala 
        195                 200                 205             


Asn Asn His Leu Asn Ala Ile Glu Glu Pro Asp Asp Ser Leu Ala Arg 
    210                 215                 220                 


Leu Phe Pro Asn Leu Arg Ser Ile Ser Leu His Lys Ser Gly Leu Gln 
225                 230                 235                 240 


Ser Trp Glu Asp Ile Asp Lys Leu Asn Ser Phe Pro Lys Leu Glu Glu 
                245                 250                 255     


Val Arg Leu Leu Gly Ile Pro Leu Leu Gln Pro Tyr Thr Thr Glu Glu 
            260                 265                 270         


Arg Arg Lys Leu Val Ile Ala Arg Leu Pro Ser Val Ser Lys Leu Asn 
        275                 280                 285             


Gly Ser Val Val Thr Asp Gly Glu Arg Glu Asp Ser Glu Arg Phe Phe 
    290                 295                 300                 


Ile Arg Tyr Tyr Val Asp Val Pro Gln Glu Glu Val Pro Phe Arg Tyr 
305                 310                 315                 320 


His Glu Leu Ile Thr Lys Tyr Gly Lys Leu Glu Pro Leu Ala Glu Val 
                325                 330                 335     


Asp Leu Arg Pro Gln Ser Ser Ala Lys Val Glu Val His Phe Asn Asp 
            340                 345                 350         


Gln Val Glu Glu Met Ser Ile Arg Leu Asp Gln Thr Val Ala Glu Leu 
        355                 360                 365             


Lys Lys Gln Leu Lys Thr Leu Val Gln Leu Pro Thr Ser Asn Met Leu 
    370                 375                 380                 


Leu Tyr Tyr Phe Asp His Glu Ala Pro Phe Gly Pro Glu Glu Met Lys 
385                 390                 395                 400 


Tyr Ser Ser Arg Ala Leu His Ser Phe Gly Ile Arg Asp Gly Asp Lys 
                405                 410                 415     


Ile Tyr Val Glu Ser Lys Thr Lys 
            420                 


<210> 7428
<211> 87
<212> PRT
<213> Homo sapiens

<400> 7428
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ala Val 
                85          


<210> 7429
<211> 119
<212> PRT
<213> Homo sapiens

<400> 7429
Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Val Glu Ser Lys Asn Val Ala Leu Pro Lys Gly Thr 
    50                  55                  60                  


Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile Ser Asp Gly 
65                  70                  75                  80  


Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr Ile Pro Leu 
                85                  90                  95      


Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr Ala Tyr Phe 
            100                 105                 110         


Gly Leu Leu Glu Ile Cys Gly 
        115                 


<210> 7430
<211> 7968
<212> PRT
<213> Homo sapiens

<400> 7430
Met Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro 
1               5                   10                  15      


Lys Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Cys Gln 
            20                  25                  30          


Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln 
        35                  40                  45              


Pro Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu 
    50                  55                  60                  


Tyr Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr 
65                  70                  75                  80  


Val Cys Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Ala Val Gly 
                85                  90                  95      


Leu Gln Val Asp Ala Glu Ala Ala Cys Ala Glu Gln Ala Pro His Phe 
            100                 105                 110         


Leu Leu Arg Pro Thr Ser Ile Arg Val Arg Glu Gly Ser Glu Ala Thr 
        115                 120                 125             


Phe Arg Cys Arg Val Gly Gly Ser Pro Arg Pro Ala Val Ser Trp Ser 
    130                 135                 140                 


Lys Asp Gly Arg Arg Leu Gly Glu Pro Asp Gly Pro Arg Val Arg Val 
145                 150                 155                 160 


Glu Glu Leu Gly Glu Ala Ser Ala Leu Arg Ile Arg Ala Ala Arg Pro 
                165                 170                 175     


Arg Asp Gly Gly Thr Tyr Glu Val Arg Ala Glu Asn Pro Leu Gly Ala 
            180                 185                 190         


Ala Ser Ala Ala Ala Ala Leu Val Val Asp Ser Asp Ala Ala Asp Thr 
        195                 200                 205             


Ala Ser Arg Pro Gly Thr Ser Thr Ala Ala Leu Leu Ala His Leu Gln 
    210                 215                 220                 


Arg Arg Arg Glu Ala Met Arg Ala Glu Gly Ala Pro Ala Ser Pro Pro 
225                 230                 235                 240 


Ser Thr Gly Thr Arg Thr Cys Thr Val Thr Glu Gly Lys His Ala Arg 
                245                 250                 255     


Leu Ser Cys Tyr Val Thr Gly Glu Pro Lys Pro Glu Thr Val Trp Lys 
            260                 265                 270         


Lys Asp Gly Gln Leu Val Thr Glu Gly Arg Arg His Val Val Tyr Glu 
        275                 280                 285             


Asp Ala Gln Glu Asn Phe Val Leu Lys Ile Leu Phe Cys Lys Gln Ser 
    290                 295                 300                 


Asp Arg Gly Leu Tyr Thr Cys Thr Ala Ser Asn Leu Val Gly Gln Thr 
305                 310                 315                 320 


Tyr Ser Ser Val Leu Val Val Val Arg Glu Pro Ala Val Pro Phe Lys 
                325                 330                 335     


Lys Arg Leu Gln Asp Leu Glu Val Arg Glu Lys Glu Ser Ala Thr Phe 
            340                 345                 350         


Leu Cys Glu Val Pro Gln Pro Ser Thr Glu Ala Ala Trp Phe Lys Glu 
        355                 360                 365             


Glu Thr Arg Leu Trp Ala Ser Ala Lys Tyr Gly Ile Glu Glu Glu Gly 
    370                 375                 380                 


Thr Glu Arg Arg Leu Thr Val Arg Asn Val Ser Ala Asp Asp Asp Ala 
385                 390                 395                 400 


Val Tyr Ile Cys Glu Thr Pro Glu Gly Ser Arg Thr Val Ala Glu Leu 
                405                 410                 415     


Ala Val Gln Gly Asn Leu Leu Arg Lys Leu Pro Arg Lys Thr Ala Val 
            420                 425                 430         


Arg Val Gly Asp Thr Ala Met Phe Cys Val Glu Leu Ala Val Pro Val 
        435                 440                 445             


Gly Pro Val His Trp Leu Arg Asn Gln Glu Glu Val Val Ala Gly Gly 
    450                 455                 460                 


Arg Val Ala Ile Ser Ala Glu Gly Thr Arg His Thr Leu Thr Ile Ser 
465                 470                 475                 480 


Gln Cys Cys Leu Glu Asp Val Gly Gln Val Ala Phe Met Ala Gly Asp 
                485                 490                 495     


Cys Gln Thr Ser Thr Gln Phe Cys Val Ser Ala Pro Arg Lys Pro Pro 
            500                 505                 510         


Leu Gln Pro Pro Val Asp Pro Val Val Lys Ala Arg Met Glu Ser Ser 
        515                 520                 525             


Val Ile Leu Ser Trp Ser Pro Pro Pro His Gly Glu Arg Pro Val Thr 
    530                 535                 540                 


Ile Asp Gly Tyr Leu Val Glu Lys Lys Lys Leu Gly Thr Tyr Thr Trp 
545                 550                 555                 560 


Ile Arg Cys His Glu Ala Glu Trp Val Ala Thr Pro Glu Leu Thr Val 
                565                 570                 575     


Ala Asp Val Ala Glu Glu Gly Asn Phe Gln Phe Arg Val Ser Ala Leu 
            580                 585                 590         


Asn Ser Phe Gly Gln Ser Pro Tyr Leu Glu Phe Pro Gly Thr Val His 
        595                 600                 605             


Leu Ala Pro Lys Leu Ala Val Arg Thr Pro Leu Lys Ala Val Gln Ala 
    610                 615                 620                 


Val Glu Gly Gly Glu Val Thr Phe Ser Val Asp Leu Thr Val Ala Ser 
625                 630                 635                 640 


Ala Gly Glu Trp Phe Leu Asp Gly Gln Ala Leu Lys Ala Ser Ser Val 
                645                 650                 655     


Tyr Glu Ile His Cys Asp Arg Thr Arg His Thr Leu Thr Ile Arg Glu 
            660                 665                 670         


Val Pro Ala Ser Leu His Gly Ala Gln Leu Lys Phe Val Ala Asn Gly 
        675                 680                 685             


Ile Glu Ser Ser Ile Arg Met Glu Val Arg Ala Ala Pro Gly Leu Thr 
    690                 695                 700                 


Ala Asn Lys Pro Pro Ala Ala Ala Ala Arg Glu Val Leu Ala Arg Leu 
705                 710                 715                 720 


His Glu Glu Ala Gln Leu Leu Ala Glu Leu Ser Asp Gln Ala Ala Ala 
                725                 730                 735     


Val Thr Trp Leu Lys Asp Gly Arg Thr Leu Ser Pro Gly Pro Lys Tyr 
            740                 745                 750         


Glu Val Gln Ala Ser Ala Gly Arg Arg Val Leu Leu Val Arg Asp Val 
        755                 760                 765             


Ala Arg Asp Asp Ala Gly Leu Tyr Glu Cys Val Ser Arg Gly Gly Arg 
    770                 775                 780                 


Ile Ala Tyr Gln Leu Ser Val Gln Gly Leu Ala Arg Phe Leu His Lys 
785                 790                 795                 800 


Asp Met Ala Gly Ser Cys Val Asp Ala Val Ala Gly Gly Pro Ala Gln 
                805                 810                 815     


Phe Glu Cys Glu Thr Ser Glu Ala His Val His Val His Trp Tyr Lys 
            820                 825                 830         


Asp Gly Met Glu Leu Gly His Ser Gly Glu Arg Phe Leu Gln Glu Asp 
        835                 840                 845             


Val Gly Thr Arg His Arg Leu Val Ala Ala Thr Val Thr Arg Gln Asp 
    850                 855                 860                 


Glu Gly Thr Tyr Ser Cys Arg Val Gly Glu Asp Ser Val Asp Phe Arg 
865                 870                 875                 880 


Leu Arg Val Ser Glu Pro Lys Val Val Phe Ala Lys Glu Gln Leu Ala 
                885                 890                 895     


Arg Arg Lys Leu Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys 
            900                 905                 910         


Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys 
        915                 920                 925             


Lys Leu Ser Ser Ser Ser Lys Val Cys Met Glu Ala Thr Gly Cys Thr 
    930                 935                 940                 


Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr 
945                 950                 955                 960 


Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu Asp Val Lys 
                965                 970                 975     


Glu Pro Lys Val Val Phe Ala Lys Asp Gln Val Ala His Ser Glu Val 
            980                 985                 990         


Gln Ala Glu Ala Gly Ala Ser Ala  Thr Leu Ser Cys Glu  Val Ala Gln 
        995                 1000                 1005             


Ala Gln  Thr Glu Val Met Trp  Tyr Lys Asp Gly Lys  Lys Leu Ser 
    1010                 1015                 1020             


Ser Ser  Leu Lys Val His Val  Glu Ala Lys Gly Cys  Arg Arg Arg 
    1025                 1030                 1035             


Leu Val  Val Gln Gln Ala Gly  Lys Thr Asp Ala Gly  Asp Tyr Ser 
    1040                 1045                 1050             


Cys Glu  Ala Arg Gly Gln Arg  Val Ser Phe Arg Leu  His Ile Thr 
    1055                 1060                 1065             


Glu Pro  Lys Met Met Phe Ala  Lys Glu Gln Ser Val  His Asn Glu 
    1070                 1075                 1080             


Val Gln  Ala Glu Ala Gly Ala  Ser Ala Met Leu Ser  Cys Glu Val 
    1085                 1090                 1095             


Ala Gln  Ala Gln Thr Glu Val  Thr Trp Tyr Lys Asp  Gly Lys Lys 
    1100                 1105                 1110             


Leu Ser  Ser Ser Ser Lys Val  Gly Met Glu Val Lys  Gly Cys Thr 
    1115                 1120                 1125             


Arg Arg  Leu Val Leu Pro Gln  Ala Gly Lys Ala Asp  Ala Gly Glu 
    1130                 1135                 1140             


Tyr Ser  Cys Glu Ala Gly Gly  Gln Arg Val Ser Phe  His Leu His 
    1145                 1150                 1155             


Ile Thr  Glu Pro Lys Gly Val  Phe Ala Lys Glu Gln  Ser Val His 
    1160                 1165                 1170             


Asn Glu  Val Gln Ala Glu Ala  Gly Thr Thr Ala Met  Leu Ser Cys 
    1175                 1180                 1185             


Glu Val  Ala Gln Pro Gln Thr  Glu Val Thr Trp Tyr  Lys Asp Gly 
    1190                 1195                 1200             


Lys Lys  Leu Ser Ser Ser Ser  Lys Val Arg Met Glu  Val Lys Gly 
    1205                 1210                 1215             


Cys Thr  Arg Arg Leu Val Val  Gln Gln Val Gly Lys  Ala Asp Ala 
    1220                 1225                 1230             


Gly Glu  Tyr Ser Cys Glu Ala  Gly Gly Gln Arg Val  Ser Phe Gln 
    1235                 1240                 1245             


Leu His  Ile Thr Glu Pro Lys  Ala Val Phe Ala Lys  Glu Gln Leu 
    1250                 1255                 1260             


Val His  Asn Glu Val Arg Thr  Glu Ala Gly Ala Ser  Ala Thr Leu 
    1265                 1270                 1275             


Ser Cys  Glu Val Ala Gln Ala  Gln Thr Glu Val Thr  Trp Tyr Lys 
    1280                 1285                 1290             


Asp Gly  Lys Lys Leu Ser Ser  Ser Ser Lys Val Arg  Ile Glu Ala 
    1295                 1300                 1305             


Ala Gly  Cys Met Arg Gln Leu  Val Val Gln Gln Ala  Gly Gln Ala 
    1310                 1315                 1320             


Asp Ala  Gly Glu Tyr Thr Cys  Glu Ala Gly Gly Gln  Arg Leu Ser 
    1325                 1330                 1335             


Phe His  Leu Asp Val Ser Glu  Pro Lys Ala Val Phe  Ala Lys Glu 
    1340                 1345                 1350             


Gln Leu  Ala His Arg Lys Val  Gln Ala Glu Ala Gly  Ala Ile Ala 
    1355                 1360                 1365             


Thr Leu  Ser Cys Glu Val Ala  Gln Ala Gln Thr Glu  Val Thr Trp 
    1370                 1375                 1380             


Tyr Lys  Asp Gly Lys Lys Leu  Ser Ser Ser Ser Lys  Val Arg Met 
    1385                 1390                 1395             


Glu Ala  Val Gly Cys Thr Arg  Arg Leu Val Val Gln  Gln Ala Cys 
    1400                 1405                 1410             


Gln Ala  Asp Thr Gly Glu Tyr  Ser Cys Glu Ala Gly  Gly Gln Arg 
    1415                 1420                 1425             


Leu Ser  Phe Ser Leu Asp Val  Ala Glu Pro Lys Val  Val Phe Ala 
    1430                 1435                 1440             


Lys Glu  Gln Pro Val His Arg  Glu Val Gln Ala Gln  Ala Gly Ala 
    1445                 1450                 1455             


Ser Thr  Thr Leu Ser Cys Glu  Val Ala Gln Ala Gln  Thr Glu Val 
    1460                 1465                 1470             


Met Trp  Tyr Lys Asp Gly Lys  Lys Leu Ser Phe Ser  Ser Lys Val 
    1475                 1480                 1485             


Arg Met  Glu Ala Val Gly Cys  Thr Arg Arg Leu Val  Val Gln Gln 
    1490                 1495                 1500             


Ala Gly  Gln Ala Val Ala Gly  Glu Tyr Ser Cys Glu  Ala Gly Ser 
    1505                 1510                 1515             


Gln Arg  Leu Ser Phe His Leu  His Val Ala Glu Pro  Lys Ala Val 
    1520                 1525                 1530             


Phe Ala  Lys Glu Gln Pro Ala  Ser Arg Glu Val Gln  Ala Glu Ala 
    1535                 1540                 1545             


Gly Thr  Ser Ala Thr Leu Ser  Cys Glu Val Ala Gln  Ala Gln Thr 
    1550                 1555                 1560             


Glu Val  Thr Trp Tyr Lys Asp  Gly Lys Lys Leu Ser  Ser Ser Ser 
    1565                 1570                 1575             


Lys Val  Arg Met Glu Ala Val  Gly Cys Thr Arg Arg  Leu Val Val 
    1580                 1585                 1590             


Gln Glu  Ala Gly Gln Ala Asp  Ala Gly Glu Tyr Ser  Cys Lys Ala 
    1595                 1600                 1605             


Gly Asp  Gln Arg Leu Ser Phe  His Leu His Val Ala  Glu Pro Lys 
    1610                 1615                 1620             


Val Val  Phe Ala Lys Glu Gln  Pro Ala His Arg Glu  Val Gln Ala 
    1625                 1630                 1635             


Glu Ala  Gly Ala Ser Ala Thr  Leu Ser Cys Glu Val  Ala Gln Ala 
    1640                 1645                 1650             


Gln Thr  Glu Val Thr Trp Tyr  Lys Asp Gly Lys Lys  Leu Ser Ser 
    1655                 1660                 1665             


Ser Ser  Lys Val Arg Val Glu  Ala Val Gly Cys Thr  Arg Arg Leu 
    1670                 1675                 1680             


Val Val  Gln Gln Ala Gly Gln  Ala Glu Ala Gly Glu  Tyr Ser Cys 
    1685                 1690                 1695             


Glu Ala  Gly Gly Gln Gln Leu  Ser Phe Arg Leu Gln  Val Ala Glu 
    1700                 1705                 1710             


Leu Glu  Pro Gln Ile Ser Glu  Arg Pro Cys Arg Arg  Glu Pro Leu 
    1715                 1720                 1725             


Val Val  Lys Glu His Glu Asp  Ile Ile Leu Thr Ala  Thr Leu Ala 
    1730                 1735                 1740             


Thr Pro  Ser Ala Ala Thr Val  Thr Trp Leu Lys Asp  Gly Val Glu 
    1745                 1750                 1755             


Ile Arg  Arg Ser Lys Arg His  Glu Thr Ala Ser Gln  Gly Asp Thr 
    1760                 1765                 1770             


His Thr  Leu Thr Val His Gly  Ala Gln Val Leu Asp  Ser Ala Ile 
    1775                 1780                 1785             


Tyr Ser  Cys Arg Val Gly Ala  Glu Gly Gln Asp Phe  Pro Val Gln 
    1790                 1795                 1800             


Val Glu  Glu Val Ala Ala Lys  Phe Cys Arg Leu Leu  Glu Pro Val 
    1805                 1810                 1815             


Cys Gly  Glu Leu Gly Gly Thr  Val Thr Leu Ala Cys  Glu Leu Ser 
    1820                 1825                 1830             


Pro Ala  Cys Ala Glu Val Val  Trp Arg Cys Gly Asn  Thr Gln Leu 
    1835                 1840                 1845             


Arg Val  Gly Lys Arg Phe Gln  Met Val Ala Glu Gly  Pro Val Arg 
    1850                 1855                 1860             


Ser Leu  Thr Val Leu Gly Leu  Arg Ala Glu Asp Ala  Gly Glu Tyr 
    1865                 1870                 1875             


Val Cys  Glu Ser Arg Asp Asp  His Thr Ser Ala Gln  Leu Thr Val 
    1880                 1885                 1890             


Ser Val  Pro Arg Val Val Lys  Phe Met Ser Gly Leu  Ser Thr Val 
    1895                 1900                 1905             


Val Ala  Glu Glu Gly Gly Glu  Ala Thr Phe Gln Cys  Val Val Ser 
    1910                 1915                 1920             


Pro Ser  Asp Val Ala Val Val  Trp Phe Arg Asp Gly  Ala Leu Leu 
    1925                 1930                 1935             


Gln Pro  Ser Glu Lys Phe Ala  Ile Ser Gln Ser Gly  Ala Ser His 
    1940                 1945                 1950             


Ser Leu  Thr Ile Ser Asp Leu  Val Leu Glu Asp Ala  Gly Gln Ile 
    1955                 1960                 1965             


Thr Val  Glu Ala Glu Gly Ala  Ser Ser Ser Ala Ala  Leu Arg Val 
    1970                 1975                 1980             


Arg Glu  Ala Pro Val Leu Phe  Lys Lys Lys Leu Glu  Pro Gln Thr 
    1985                 1990                 1995             


Val Glu  Glu Arg Ser Ser Val  Thr Leu Glu Val Glu  Leu Thr Arg 
    2000                 2005                 2010             


Pro Trp  Pro Glu Leu Arg Trp  Thr Arg Asn Ala Thr  Ala Leu Ala 
    2015                 2020                 2025             


Pro Gly  Lys Asn Val Glu Ile  His Ala Glu Gly Ala  Arg His Arg 
    2030                 2035                 2040             


Leu Val  Leu His Asn Val Gly  Phe Ala Asp Arg Gly  Phe Phe Gly 
    2045                 2050                 2055             


Cys Glu  Thr Pro Asp Asp Lys  Thr Gln Ala Lys Leu  Thr Val Glu 
    2060                 2065                 2070             


Met Arg  Gln Val Arg Leu Val  Arg Gly Leu Gln Ala  Val Glu Ala 
    2075                 2080                 2085             


Arg Glu  Gln Gly Thr Ala Thr  Met Glu Val Gln Leu  Ser His Ala 
    2090                 2095                 2100             


Asp Val  Asp Gly Ser Trp Thr  Arg Asp Gly Leu Arg  Phe Gln Gln 
    2105                 2110                 2115             


Gly Pro  Thr Cys His Leu Ala  Val Arg Gly Pro Met  His Thr Leu 
    2120                 2125                 2130             


Thr Leu  Ser Gly Leu Arg Pro  Glu Asp Ser Gly Leu  Met Val Phe 
    2135                 2140                 2145             


Lys Ala  Glu Gly Val His Thr  Ser Ala Arg Leu Val  Val Thr Glu 
    2150                 2155                 2160             


Leu Pro  Val Ser Phe Ser Arg  Pro Leu Gln Asp Val  Val Thr Thr 
    2165                 2170                 2175             


Glu Lys  Glu Lys Val Thr Leu  Glu Cys Glu Leu Ser  Arg Pro Asn 
    2180                 2185                 2190             


Val Asp  Val Arg Trp Leu Lys  Asp Gly Val Glu Leu  Arg Ala Gly 
    2195                 2200                 2205             


Lys Thr  Met Ala Ile Ala Ala  Gln Gly Ala Cys Arg  Ser Leu Thr 
    2210                 2215                 2220             


Ile Tyr  Arg Cys Glu Phe Ala  Asp Gln Gly Val Tyr  Val Cys Asp 
    2225                 2230                 2235             


Ala His  Asp Ala Gln Ser Ser  Ala Ser Val Lys Val  Gln Gly Arg 
    2240                 2245                 2250             


Thr Tyr  Thr Leu Ile Tyr Arg  Arg Val Leu Ala Glu  Asp Ala Gly 
    2255                 2260                 2265             


Glu Ile  Gln Phe Val Ala Glu  Asn Ala Glu Ser Arg  Ala Gln Leu 
    2270                 2275                 2280             


Arg Val  Lys Glu Leu Pro Val  Thr Leu Val Arg Pro  Leu Arg Asp 
    2285                 2290                 2295             


Lys Ile  Ala Met Glu Lys His  Arg Gly Val Leu Glu  Cys Gln Val 
    2300                 2305                 2310             


Ser Arg  Ala Ser Ala Gln Val  Arg Trp Phe Lys Gly  Ser Gln Glu 
    2315                 2320                 2325             


Leu Gln  Pro Gly Pro Lys Tyr  Glu Leu Val Ser Asp  Gly Leu Tyr 
    2330                 2335                 2340             


Arg Lys  Leu Ile Ile Ser Asp  Val His Ala Glu Asp  Glu Asp Thr 
    2345                 2350                 2355             


Tyr Thr  Cys Asp Ala Gly Asp  Val Lys Thr Ser Ala  Gln Phe Phe 
    2360                 2365                 2370             


Val Glu  Glu Gln Ser Ile Thr  Ile Val Arg Gly Leu  Gln Asp Val 
    2375                 2380                 2385             


Thr Val  Met Glu Pro Ala Pro  Ala Trp Phe Glu Cys  Glu Thr Ser 
    2390                 2395                 2400             


Ile Pro  Ser Val Arg Pro Pro  Lys Trp Leu Leu Gly  Lys Thr Val 
    2405                 2410                 2415             


Leu Gln  Ala Gly Gly Asn Val  Gly Leu Glu Gln Glu  Gly Thr Val 
    2420                 2425                 2430             


His Arg  Leu Met Leu Arg Arg  Thr Cys Ser Thr Met  Thr Gly Pro 
    2435                 2440                 2445             


Val His  Phe Thr Val Gly Lys  Ser Arg Ser Ser Ala  Arg Leu Val 
    2450                 2455                 2460             


Val Ser  Asp Ile Pro Val Val  Leu Thr Arg Pro Leu  Glu Pro Lys 
    2465                 2470                 2475             


Thr Gly  Arg Glu Leu Gln Ser  Val Val Leu Ser Cys  Asp Phe Arg 
    2480                 2485                 2490             


Pro Ala  Pro Lys Ala Val Gln  Trp Tyr Lys Asp Asp  Thr Pro Leu 
    2495                 2500                 2505             


Ser Pro  Ser Glu Lys Phe Lys  Met Ser Leu Glu Gly  Gln Met Ala 
    2510                 2515                 2520             


Glu Leu  Arg Ile Leu Arg Leu  Met Pro Ala Asp Ala  Gly Val Tyr 
    2525                 2530                 2535             


Arg Cys  Gln Ala Gly Ser Ala  His Ser Ser Thr Glu  Val Thr Val 
    2540                 2545                 2550             


Glu Ala  Arg Glu Val Thr Val  Thr Gly Pro Leu Gln  Asp Ala Glu 
    2555                 2560                 2565             


Ala Thr  Glu Glu Gly Trp Ala  Ser Phe Ser Cys Glu  Leu Ser His 
    2570                 2575                 2580             


Glu Asp  Glu Glu Val Glu Trp  Ser Leu Asn Gly Met  Pro Leu Tyr 
    2585                 2590                 2595             


Asn Asp  Ser Phe His Glu Ile  Ser His Lys Gly Arg  Arg His Thr 
    2600                 2605                 2610             


Leu Val  Leu Lys Ser Ile Gln  Arg Ala Asp Ala Gly  Ile Val Arg 
    2615                 2620                 2625             


Ala Ser  Ser Leu Lys Val Ser  Thr Ser Ala Arg Leu  Glu Val Arg 
    2630                 2635                 2640             


Val Lys  Pro Val Val Phe Leu  Lys Ala Leu Asp Asp  Leu Ser Ala 
    2645                 2650                 2655             


Glu Glu  Arg Gly Thr Leu Ala  Leu Gln Cys Glu Val  Ser Asp Pro 
    2660                 2665                 2670             


Glu Ala  His Val Val Trp Arg  Lys Asp Gly Val Gln  Leu Gly Pro 
    2675                 2680                 2685             


Ser Asp  Lys Tyr Asp Phe Leu  His Thr Ala Gly Thr  Arg Gly Leu 
    2690                 2695                 2700             


Val Val  His Asp Val Ser Pro  Glu Asp Ala Gly Leu  Tyr Thr Cys 
    2705                 2710                 2715             


His Val  Gly Ser Glu Glu Thr  Arg Ala Arg Val Arg  Val His Asp 
    2720                 2725                 2730             


Leu His  Val Gly Ile Thr Lys  Arg Leu Lys Thr Met  Glu Val Leu 
    2735                 2740                 2745             


Glu Gly  Glu Ser Cys Ser Phe  Glu Cys Val Leu Ser  His Glu Ser 
    2750                 2755                 2760             


Ala Ser  Asp Pro Ala Met Trp  Thr Val Gly Gly Lys  Thr Val Gly 
    2765                 2770                 2775             


Ser Ser  Ser Arg Phe Gln Ala  Thr Arg Gln Gly Arg  Lys Tyr Ile 
    2780                 2785                 2790             


Leu Val  Val Arg Glu Ala Ala  Pro Ser Asp Ala Gly  Glu Val Val 
    2795                 2800                 2805             


Phe Ser  Val Arg Gly Leu Thr  Ser Lys Ala Ser Leu  Ile Val Arg 
    2810                 2815                 2820             


Glu Arg  Pro Ala Ala Ile Ile  Lys Pro Leu Glu Asp  Gln Trp Val 
    2825                 2830                 2835             


Ala Pro  Gly Glu Asp Val Glu  Leu Arg Cys Glu Leu  Ser Arg Ala 
    2840                 2845                 2850             


Gly Thr  Pro Val His Trp Leu  Lys Asp Arg Lys Ala  Ile Arg Lys 
    2855                 2860                 2865             


Ser Gln  Lys Tyr Asp Val Val  Cys Glu Gly Thr Met  Ala Met Leu 
    2870                 2875                 2880             


Val Ile  Arg Gly Ala Ser Leu  Lys Asp Ala Gly Glu  Tyr Thr Cys 
    2885                 2890                 2895             


Glu Val  Glu Ala Ser Lys Ser  Thr Ala Ser Leu His  Val Glu Glu 
    2900                 2905                 2910             


Lys Ala  Asn Cys Phe Thr Glu  Glu Leu Thr Asn Leu  Gln Val Glu 
    2915                 2920                 2925             


Glu Lys  Gly Thr Ala Val Phe  Thr Cys Lys Thr Glu  His Pro Ala 
    2930                 2935                 2940             


Ala Thr  Val Thr Trp Arg Lys  Gly Leu Leu Glu Leu  Arg Ala Ser 
    2945                 2950                 2955             


Gly Lys  His Gln Pro Ser Gln  Glu Gly Leu Thr Leu  Arg Leu Thr 
    2960                 2965                 2970             


Ile Ser  Ala Leu Glu Lys Ala  Asp Ser Asp Thr Tyr  Thr Cys Asp 
    2975                 2980                 2985             


Ile Gly  Gln Ala Gln Ser Arg  Ala Gln Leu Leu Val  Gln Gly Arg 
    2990                 2995                 3000             


Arg Val  His Ile Ile Glu Asp  Leu Glu Asp Val Asp  Val Gln Glu 
    3005                 3010                 3015             


Gly Ser  Ser Ala Thr Phe Arg  Cys Arg Ile Ser Pro  Ala Asn Tyr 
    3020                 3025                 3030             


Glu Pro  Val His Trp Phe Leu  Asp Lys Thr Pro Leu  His Ala Asn 
    3035                 3040                 3045             


Glu Leu  Asn Glu Ile Asp Ala  Gln Pro Gly Gly Tyr  His Val Leu 
    3050                 3055                 3060             


Thr Leu  Arg Gln Leu Ala Leu  Lys Asp Ser Gly Thr  Ile Tyr Phe 
    3065                 3070                 3075             


Glu Ala  Gly Asp Gln Arg Ala  Ser Ala Ala Leu Arg  Val Thr Glu 
    3080                 3085                 3090             


Lys Pro  Ser Val Phe Ser Arg  Glu Leu Thr Asp Ala  Thr Ile Thr 
    3095                 3100                 3105             


Glu Gly  Glu Asp Leu Thr Leu  Val Cys Glu Thr Ser  Thr Cys Asp 
    3110                 3115                 3120             


Ile Pro  Val Cys Trp Thr Lys  Asp Gly Lys Thr Leu  Arg Gly Ser 
    3125                 3130                 3135             


Ala Arg  Cys Gln Leu Ser His  Glu Gly His Arg Ala  Gln Leu Leu 
    3140                 3145                 3150             


Ile Thr  Gly Ala Thr Leu Gln  Asp Ser Gly Arg Tyr  Lys Cys Glu 
    3155                 3160                 3165             


Ala Gly  Gly Ala Cys Ser Ser  Ser Ile Val Arg Val  His Ala Arg 
    3170                 3175                 3180             


Pro Val  Arg Phe Gln Glu Ala  Leu Lys Asp Leu Glu  Val Leu Glu 
    3185                 3190                 3195             


Gly Gly  Ala Ala Thr Leu Arg  Cys Val Leu Ser Ser  Val Ala Ala 
    3200                 3205                 3210             


Pro Val  Lys Trp Cys Tyr Gly  Asn Asn Val Leu Arg  Pro Gly Asp 
    3215                 3220                 3225             


Lys Tyr  Ser Leu Arg Gln Glu  Gly Ala Met Leu Glu  Leu Val Val 
    3230                 3235                 3240             


Arg Asn  Leu Arg Pro Gln Asp  Ser Gly Arg Tyr Ser  Cys Ser Phe 
    3245                 3250                 3255             


Gly Asp  Gln Thr Thr Ser Ala  Thr Leu Thr Val Thr  Ala Leu Pro 
    3260                 3265                 3270             


Ala Gln  Phe Ile Gly Lys Leu  Arg Asn Lys Glu Ala  Thr Glu Gly 
    3275                 3280                 3285             


Ala Thr  Ala Thr Leu Arg Cys  Glu Leu Ser Lys Ala  Ala Pro Val 
    3290                 3295                 3300             


Glu Trp  Arg Lys Gly Ser Glu  Thr Leu Arg Asp Gly  Asp Arg Tyr 
    3305                 3310                 3315             


Cys Leu  Arg Gln Asp Gly Ala  Met Cys Glu Leu Gln  Ile Arg Gly 
    3320                 3325                 3330             


Leu Ala  Met Val Asp Ala Ala  Glu Tyr Ser Cys Val  Cys Gly Glu 
    3335                 3340                 3345             


Glu Arg  Thr Ser Ala Ser Leu  Thr Ile Arg Pro Met  Pro Ala His 
    3350                 3355                 3360             


Phe Ile  Gly Arg Leu Arg His  Gln Glu Ser Ile Glu  Gly Ala Thr 
    3365                 3370                 3375             


Ala Thr  Leu Arg Cys Glu Leu  Ser Lys Ala Ala Pro  Val Glu Trp 
    3380                 3385                 3390             


Arg Lys  Gly Arg Glu Ser Leu  Arg Asp Gly Asp Arg  His Ser Leu 
    3395                 3400                 3405             


Arg Gln  Asp Gly Ala Val Cys  Glu Leu Gln Ile Cys  Gly Leu Ala 
    3410                 3415                 3420             


Val Ala  Asp Ala Gly Glu Tyr  Ser Cys Val Cys Gly  Glu Glu Arg 
    3425                 3430                 3435             


Thr Ser  Ala Thr Leu Thr Val  Lys Ala Leu Pro Ala  Lys Phe Thr 
    3440                 3445                 3450             


Glu Gly  Leu Arg Asn Glu Glu  Ala Val Glu Gly Ala  Thr Ala Met 
    3455                 3460                 3465             


Leu Trp  Cys Glu Leu Ser Lys  Val Ala Pro Val Glu  Trp Arg Lys 
    3470                 3475                 3480             


Gly Pro  Glu Asn Leu Arg Asp  Gly Asp Arg Tyr Ile  Leu Arg Gln 
    3485                 3490                 3495             


Glu Gly  Thr Arg Cys Glu Leu  Gln Ile Cys Gly Leu  Ala Met Ala 
    3500                 3505                 3510             


Asp Ala  Gly Glu Tyr Leu Cys  Val Cys Gly Gln Glu  Arg Thr Ser 
    3515                 3520                 3525             


Ala Thr  Leu Thr Ile Arg Ala  Leu Pro Ala Arg Phe  Ile Glu Asp 
    3530                 3535                 3540             


Val Lys  Asn Gln Glu Ala Arg  Glu Gly Ala Thr Ala  Val Leu Gln 
    3545                 3550                 3555             


Cys Glu  Leu Asn Ser Ala Ala  Pro Val Glu Trp Arg  Lys Gly Ser 
    3560                 3565                 3570             


Glu Thr  Leu Arg Asp Gly Asp  Arg Tyr Ser Leu Arg  Gln Asp Gly 
    3575                 3580                 3585             


Thr Lys  Cys Glu Leu Gln Ile  Arg Gly Leu Ala Met  Ala Asp Thr 
    3590                 3595                 3600             


Gly Glu  Tyr Ser Cys Val Cys  Gly Gln Glu Arg Thr  Ser Ala Met 
    3605                 3610                 3615             


Leu Thr  Val Arg Ala Leu Pro  Ile Lys Phe Thr Glu  Gly Leu Arg 
    3620                 3625                 3630             


Asn Glu  Glu Ala Thr Glu Gly  Ala Thr Ala Val Leu  Arg Cys Glu 
    3635                 3640                 3645             


Leu Ser  Lys Met Ala Pro Val  Glu Trp Trp Lys Gly  His Glu Thr 
    3650                 3655                 3660             


Leu Arg  Asp Gly Asp Arg His  Ser Leu Arg Gln Asp  Gly Ala Arg 
    3665                 3670                 3675             


Cys Glu  Leu Gln Ile Arg Gly  Leu Val Ala Glu Asp  Ala Gly Glu 
    3680                 3685                 3690             


Tyr Leu  Cys Met Cys Gly Lys  Glu Arg Thr Ser Ala  Met Leu Thr 
    3695                 3700                 3705             


Val Arg  Ala Met Pro Ser Lys  Phe Ile Glu Gly Leu  Arg Asn Glu 
    3710                 3715                 3720             


Glu Ala  Thr Glu Gly Asp Thr  Ala Thr Leu Trp Cys  Glu Leu Ser 
    3725                 3730                 3735             


Lys Ala  Ala Pro Val Glu Trp  Arg Lys Gly His Glu  Thr Leu Arg 
    3740                 3745                 3750             


Asp Gly  Asp Arg His Ser Leu  Arg Gln Asp Gly Ser  Arg Cys Glu 
    3755                 3760                 3765             


Leu Gln  Ile Arg Gly Leu Ala  Val Val Asp Ala Gly  Glu Tyr Ser 
    3770                 3775                 3780             


Cys Val  Cys Gly Gln Glu Arg  Thr Ser Ala Thr Leu  Thr Val Arg 
    3785                 3790                 3795             


Ala Leu  Pro Ala Arg Phe Ile  Glu Asp Val Lys Asn  Gln Glu Ala 
    3800                 3805                 3810             


Arg Glu  Gly Ala Thr Ala Val  Leu Gln Cys Glu Leu  Ser Lys Ala 
    3815                 3820                 3825             


Ala Pro  Val Glu Trp Arg Lys  Gly Ser Glu Thr Leu  Arg Gly Gly 
    3830                 3835                 3840             


Asp Arg  Tyr Ser Leu Arg Gln  Asp Gly Thr Arg Cys  Glu Leu Gln 
    3845                 3850                 3855             


Ile His  Gly Leu Ser Val Ala  Asp Thr Gly Glu Tyr  Ser Cys Val 
    3860                 3865                 3870             


Cys Gly  Gln Glu Arg Thr Ser  Ala Thr Leu Thr Val  Arg Ala Pro 
    3875                 3880                 3885             


Gln Pro  Val Phe Arg Glu Pro  Leu Gln Ser Leu Gln  Ala Glu Glu 
    3890                 3895                 3900             


Gly Ser  Thr Ala Thr Leu Gln  Cys Glu Leu Ser Glu  Pro Thr Ala 
    3905                 3910                 3915             


Thr Val  Val Trp Ser Lys Gly  Gly Leu Gln Leu Gln  Ala Asn Gly 
    3920                 3925                 3930             


Arg Arg  Glu Pro Arg Leu Gln  Gly Cys Thr Ala Glu  Leu Val Leu 
    3935                 3940                 3945             


Gln Asp  Leu Gln Arg Glu Asp  Thr Gly Glu Tyr Thr  Cys Thr Cys 
    3950                 3955                 3960             


Gly Ser  Gln Ala Thr Ser Ala  Thr Leu Thr Val Thr  Ala Ala Pro 
    3965                 3970                 3975             


Val Arg  Phe Leu Arg Glu Leu  Gln His Gln Glu Val  Asp Glu Gly 
    3980                 3985                 3990             


Gly Thr  Ala His Leu Cys Cys  Glu Leu Ser Arg Ala  Gly Ala Ser 
    3995                 4000                 4005             


Val Glu  Trp Arg Lys Gly Ser  Leu Gln Leu Phe Pro  Cys Ala Lys 
    4010                 4015                 4020             


Tyr Gln  Met Val Gln Asp Gly  Ala Ala Ala Glu Leu  Leu Val Arg 
    4025                 4030                 4035             


Gly Val  Glu Gln Glu Asp Ala  Gly Asp Tyr Thr Cys  Asp Thr Gly 
    4040                 4045                 4050             


His Thr  Gln Ser Met Ala Ser  Leu Ser Val Arg Val  Pro Arg Pro 
    4055                 4060                 4065             


Lys Phe  Lys Thr Arg Leu Gln  Ser Leu Glu Gln Glu  Thr Gly Asp 
    4070                 4075                 4080             


Ile Ala  Arg Leu Cys Cys Gln  Leu Ser Asp Ala Glu  Ser Gly Ala 
    4085                 4090                 4095             


Val Val  Gln Trp Leu Lys Glu  Gly Val Glu Leu His  Ala Gly Pro 
    4100                 4105                 4110             


Lys Tyr  Glu Met Arg Ser Gln  Gly Ala Thr Arg Glu  Leu Leu Ile 
    4115                 4120                 4125             


His Gln  Leu Glu Ala Lys Asp  Thr Gly Glu Tyr Ala  Cys Val Thr 
    4130                 4135                 4140             


Gly Gly  Gln Lys Thr Ala Ala  Ser Leu Arg Val Thr  Glu Pro Glu 
    4145                 4150                 4155             


Val Thr  Ile Val Arg Gly Leu  Val Asp Ala Glu Val  Thr Ala Asp 
    4160                 4165                 4170             


Glu Asp  Val Glu Phe Ser Cys  Glu Val Ser Arg Ala  Gly Ala Thr 
    4175                 4180                 4185             


Gly Val  Gln Trp Cys Leu Gln  Gly Leu Pro Leu Gln  Ser Asn Glu 
    4190                 4195                 4200             


Val Thr  Glu Val Ala Val Arg  Asp Gly Arg Ile His  Thr Leu Arg 
    4205                 4210                 4215             


Leu Lys  Gly Val Thr Pro Glu  Asp Ala Gly Thr Val  Ser Phe His 
    4220                 4225                 4230             


Leu Gly  Asn His Ala Ser Ser  Ala Gln Leu Thr Val  Arg Ala Pro 
    4235                 4240                 4245             


Glu Val  Thr Ile Leu Glu Pro  Leu Gln Asp Val Gln  Leu Ser Glu 
    4250                 4255                 4260             


Gly Gln  Asp Ala Ser Phe Gln  Cys Arg Leu Ser Arg  Ala Ser Gly 
    4265                 4270                 4275             


Gln Glu  Ala Arg Trp Ala Leu  Gly Gly Val Pro Leu  Gln Ala Asn 
    4280                 4285                 4290             


Glu Met  Asn Asp Ile Thr Val  Glu Gln Gly Thr Leu  His Leu Leu 
    4295                 4300                 4305             


Thr Leu  His Lys Val Thr Leu  Glu Asp Ala Gly Thr  Val Ser Phe 
    4310                 4315                 4320             


His Val  Gly Thr Cys Ser Ser  Glu Ala Gln Leu Lys  Val Thr Ala 
    4325                 4330                 4335             


Lys Asn  Thr Val Val Arg Gly  Leu Glu Asn Val Glu  Ala Leu Glu 
    4340                 4345                 4350             


Gly Gly  Glu Ala Leu Phe Glu  Cys Gln Leu Ser Gln  Pro Glu Val 
    4355                 4360                 4365             


Ala Ala  His Thr Trp Leu Leu  Asp Asp Glu Pro Val  His Thr Ser 
    4370                 4375                 4380             


Glu Asn  Ala Glu Val Val Phe  Phe Glu Asn Gly Leu  Arg His Leu 
    4385                 4390                 4395             


Leu Leu  Leu Lys Asn Leu Arg  Pro Gln Asp Ser Cys  Arg Val Thr 
    4400                 4405                 4410             


Phe Leu  Ala Gly Asp Met Val  Thr Ser Ala Phe Leu  Thr Val Arg 
    4415                 4420                 4425             


Gly Trp  Arg Leu Glu Ile Leu  Glu Pro Leu Lys Asn  Ala Ala Val 
    4430                 4435                 4440             


Arg Ala  Gly Ala Gln Ala Cys  Phe Thr Cys Thr Leu  Ser Glu Ala 
    4445                 4450                 4455             


Val Pro  Val Gly Glu Ala Ser  Trp Tyr Ile Asn Gly  Ala Ala Val 
    4460                 4465                 4470             


Gln Pro  Asp Asp Ser Asp Trp  Thr Val Thr Ala Asp  Gly Ser His 
    4475                 4480                 4485             


His Ala  Leu Leu Leu Arg Ser  Ala Gln Pro His His  Ala Gly Glu 
    4490                 4495                 4500             


Val Thr  Phe Ala Cys Arg Asp  Ala Val Ala Ser Ala  Arg Leu Thr 
    4505                 4510                 4515             


Val Leu  Gly Leu Pro Asp Pro  Pro Glu Asp Ala Glu  Val Val Ala 
    4520                 4525                 4530             


Arg Ser  Ser His Thr Val Thr  Leu Ser Trp Ala Ala  Pro Met Ser 
    4535                 4540                 4545             


Asp Gly  Gly Gly Gly Leu Cys  Gly Tyr Arg Val Glu  Val Lys Glu 
    4550                 4555                 4560             


Gly Ala  Thr Gly Gln Trp Arg  Leu Cys His Glu Leu  Val Pro Gly 
    4565                 4570                 4575             


Pro Glu  Cys Val Val Asp Gly  Leu Ala Pro Gly Glu  Thr Tyr Arg 
    4580                 4585                 4590             


Phe Arg  Val Ala Ala Val Gly  Pro Val Gly Ala Gly  Glu Pro Val 
    4595                 4600                 4605             


His Leu  Pro Gln Thr Val Arg  Leu Ala Glu Pro Pro  Lys Pro Val 
    4610                 4615                 4620             


Pro Pro  Gln Pro Ser Ala Pro  Glu Ser Arg Gln Val  Ala Ala Gly 
    4625                 4630                 4635             


Glu Asp  Val Ser Leu Glu Leu  Glu Val Val Ala Glu  Ala Gly Glu 
    4640                 4645                 4650             


Val Ile  Trp His Lys Gly Met  Glu Arg Ile Gln Pro  Gly Gly Arg 
    4655                 4660                 4665             


Phe Glu  Val Val Ser Gln Gly  Arg Gln Gln Met Leu  Val Ile Lys 
    4670                 4675                 4680             


Gly Phe  Thr Ala Glu Asp Gln  Gly Glu Tyr His Cys  Gly Leu Ala 
    4685                 4690                 4695             


Gln Gly  Ser Ile Cys Pro Ala  Ala Ala Thr Phe Gln  Val Ala Leu 
    4700                 4705                 4710             


Ser Pro  Ala Ser Val Asp Glu  Ala Pro Gln Pro Ser  Leu Pro Pro 
    4715                 4720                 4725             


Glu Ala  Ala Gln Glu Gly Asp  Leu His Leu Leu Trp  Glu Ala Leu 
    4730                 4735                 4740             


Ala Arg  Lys Arg Arg Met Ser  Arg Glu Pro Thr Leu  Asp Ser Ile 
    4745                 4750                 4755             


Ser Glu  Leu Pro Glu Glu Asp  Gly Arg Ser Gln Arg  Leu Pro Gln 
    4760                 4765                 4770             


Glu Ala  Glu Glu Val Ala Pro  Asp Leu Ser Glu Gly  Tyr Ser Thr 
    4775                 4780                 4785             


Ala Asp  Glu Leu Ala Arg Thr  Gly Asp Ala Asp Leu  Ser His Thr 
    4790                 4795                 4800             


Ser Ser  Asp Asp Glu Ser Arg  Ala Gly Thr Pro Ser  Leu Val Thr 
    4805                 4810                 4815             


Tyr Leu  Lys Lys Ala Gly Arg  Pro Gly Thr Ser Pro  Leu Ala Ser 
    4820                 4825                 4830             


Lys Val  Gly Ala Pro Ala Ala  Pro Ser Val Lys Pro  Gln Gln Gln 
    4835                 4840                 4845             


Gln Glu  Pro Leu Ala Ala Val  Arg Pro Pro Leu Gly  Asp Leu Ser 
    4850                 4855                 4860             


Thr Lys  Asp Leu Gly Asp Pro  Ser Met Asp Lys Ala  Ala Val Lys 
    4865                 4870                 4875             


Ile Gln  Ala Ala Phe Lys Gly  Tyr Lys Val Arg Lys  Glu Met Lys 
    4880                 4885                 4890             


Gln Gln  Glu Gly Pro Met Phe  Ser His Thr Phe Gly  Asp Thr Glu 
    4895                 4900                 4905             


Ala Gln  Val Gly Asp Ala Leu  Arg Leu Glu Cys Val  Val Ala Ser 
    4910                 4915                 4920             


Lys Ala  Asp Val Arg Ala Arg  Trp Leu Lys Asp Gly  Val Glu Leu 
    4925                 4930                 4935             


Thr Asp  Gly Arg His His His  Ile Asp Gln Leu Gly  Asp Gly Thr 
    4940                 4945                 4950             


Cys Ser  Leu Leu Ile Thr Gly  Leu Asp Arg Ala Asp  Ala Gly Cys 
    4955                 4960                 4965             


Tyr Thr  Cys Gln Val Ser Asn  Lys Phe Gly Gln Val  Thr His Ser 
    4970                 4975                 4980             


Ala Cys  Val Val Val Ser Gly  Ser Glu Ser Glu Ala  Glu Ser Ser 
    4985                 4990                 4995             


Ser Gly  Gly Glu Leu Asp Asp  Ala Phe Arg Arg Ala  Ala Arg Arg 
    5000                 5005                 5010             


Leu His  Arg Leu Phe Arg Thr  Lys Ser Pro Ala Glu  Val Ser Asp 
    5015                 5020                 5025             


Glu Glu  Leu Phe Leu Ser Ala  Asp Glu Gly Pro Ala  Glu Pro Glu 
    5030                 5035                 5040             


Glu Pro  Ala Asp Trp Gln Thr  Tyr Arg Glu Asp Glu  His Phe Ile 
    5045                 5050                 5055             


Cys Ile  Arg Phe Glu Ala Leu  Thr Glu Ala Arg Gln  Ala Val Thr 
    5060                 5065                 5070             


Arg Phe  Gln Glu Met Phe Ala  Thr Leu Gly Ile Gly  Val Glu Ile 
    5075                 5080                 5085             


Lys Leu  Val Glu Gln Gly Pro  Arg Arg Val Glu Met  Cys Ile Ser 
    5090                 5095                 5100             


Lys Glu  Thr Pro Ala Pro Val  Val Pro Pro Glu Pro  Leu Pro Ser 
    5105                 5110                 5115             


Leu Leu  Thr Ser Asp Ala Ala  Pro Val Phe Leu Thr  Glu Leu Gln 
    5120                 5125                 5130             


Asn Gln  Glu Val Gln Asp Gly  Tyr Pro Val Ser Phe  Asp Cys Val 
    5135                 5140                 5145             


Val Thr  Gly Gln Pro Met Pro  Ser Val Arg Trp Phe  Lys Asp Gly 
    5150                 5155                 5160             


Lys Leu  Leu Glu Glu Asp Asp  His Tyr Met Ile Asn  Glu Asp Gln 
    5165                 5170                 5175             


Gln Gly  Gly His Gln Leu Ile  Ile Thr Ala Val Val  Pro Ala Asp 
    5180                 5185                 5190             


Met Gly  Val Tyr Arg Cys Leu  Ala Glu Asn Ser Met  Gly Val Ser 
    5195                 5200                 5205             


Ser Thr  Lys Ala Glu Leu Arg  Val Asp Leu Thr Ser  Thr Asp Tyr 
    5210                 5215                 5220             


Asp Thr  Ala Ala Asp Ala Thr  Glu Ser Ser Ser Tyr  Phe Ser Ala 
    5225                 5230                 5235             


Gln Gly  Tyr Leu Ser Ser Arg  Glu Gln Glu Gly Thr  Glu Ser Thr 
    5240                 5245                 5250             


Thr Asp  Glu Gly Gln Leu Pro  Gln Val Val Glu Glu  Leu Arg Asp 
    5255                 5260                 5265             


Leu Gln  Val Ala Pro Gly Thr  Arg Leu Ala Lys Phe  Gln Leu Lys 
    5270                 5275                 5280             


Val Lys  Gly Tyr Pro Ala Pro  Arg Leu Tyr Trp Phe  Lys Asp Gly 
    5285                 5290                 5295             


Gln Pro  Leu Thr Ala Ser Ala  His Ile Arg Met Thr  Asp Lys Lys 
    5300                 5305                 5310             


Ile Leu  His Thr Leu Glu Ile  Ile Ser Val Thr Arg  Glu Asp Ser 
    5315                 5320                 5325             


Gly Gln  Tyr Ala Ala Tyr Ile  Ser Asn Ala Met Gly  Ala Ala Tyr 
    5330                 5335                 5340             


Ser Ser  Ala Arg Leu Leu Val  Arg Gly Pro Asp Glu  Pro Glu Glu 
    5345                 5350                 5355             


Lys Pro  Ala Ser Asp Val His  Glu Gln Leu Val Pro  Pro Arg Met 
    5360                 5365                 5370             


Leu Glu  Arg Phe Thr Pro Lys  Lys Val Lys Lys Gly  Ser Ser Ile 
    5375                 5380                 5385             


Thr Phe  Ser Val Lys Val Glu  Gly Arg Pro Val Pro  Thr Val His 
    5390                 5395                 5400             


Trp Leu  Arg Glu Glu Ala Glu  Arg Gly Val Leu Trp  Ile Gly Pro 
    5405                 5410                 5415             


Asp Thr  Pro Gly Tyr Thr Val  Ala Ser Ser Ala Gln  Gln His Ser 
    5420                 5425                 5430             


Leu Val  Leu Leu Asp Val Gly  Arg Gln His Gln Gly  Thr Tyr Thr 
    5435                 5440                 5445             


Cys Ile  Ala Ser Asn Ala Ala  Gly Gln Ala Leu Cys  Ser Ala Ser 
    5450                 5455                 5460             


Leu His  Val Ser Gly Leu Pro  Lys Val Glu Glu Gln  Glu Lys Val 
    5465                 5470                 5475             


Lys Glu  Ala Leu Ile Ser Thr  Phe Leu Gln Gly Thr  Thr Gln Ala 
    5480                 5485                 5490             


Ile Ser  Ala Gln Gly Leu Glu  Thr Ala Ser Phe Ala  Asp Leu Gly 
    5495                 5500                 5505             


Gly Gln  Arg Lys Glu Glu Pro  Leu Ala Ala Lys Glu  Ala Leu Gly 
    5510                 5515                 5520             


His Leu  Ser Leu Ala Glu Val  Gly Thr Glu Glu Phe  Leu Gln Lys 
    5525                 5530                 5535             


Leu Thr  Ser Gln Ile Thr Glu  Met Val Ser Ala Lys  Ile Thr Gln 
    5540                 5545                 5550             


Ala Lys  Leu Gln Val Pro Gly  Gly Asp Ser Asp Glu  Asp Ser Lys 
    5555                 5560                 5565             


Thr Pro  Ser Ala Ser Pro Arg  His Gly Arg Ser Arg  Pro Ser Ser 
    5570                 5575                 5580             


Ser Ile  Gln Glu Ser Ser Ser  Glu Ser Glu Asp Gly  Asp Ala Arg 
    5585                 5590                 5595             


Gly Glu  Ile Phe Asp Ile Tyr  Val Val Thr Ala Asp  Tyr Leu Pro 
    5600                 5605                 5610             


Leu Gly  Ala Glu Gln Asp Ala  Ile Thr Leu Arg Glu  Gly Gln Tyr 
    5615                 5620                 5625             


Val Glu  Val Leu Asp Ala Ala  His Pro Leu Arg Trp  Leu Val Arg 
    5630                 5635                 5640             


Thr Lys  Pro Thr Lys Ser Ser  Pro Ser Arg Gln Gly  Trp Val Ser 
    5645                 5650                 5655             


Pro Ala  Tyr Leu Asp Arg Arg  Leu Lys Leu Ser Pro  Glu Trp Gly 
    5660                 5665                 5670             


Ala Ala  Glu Ala Pro Glu Phe  Pro Gly Glu Ala Val  Ser Glu Asp 
    5675                 5680                 5685             


Glu Tyr  Lys Ala Arg Leu Ser  Ser Val Ile Gln Glu  Leu Leu Ser 
    5690                 5695                 5700             


Ser Glu  Gln Ala Phe Val Glu  Glu Leu Gln Phe Leu  Gln Ser His 
    5705                 5710                 5715             


His Leu  Gln His Leu Glu Arg  Cys Pro His Val Pro  Ile Ala Val 
    5720                 5725                 5730             


Ala Gly  Gln Lys Ala Val Ile  Phe Arg Asn Val Arg  Asp Ile Gly 
    5735                 5740                 5745             


Arg Phe  His Ser Ser Phe Leu  Gln Glu Leu Gln Gln  Cys Asp Thr 
    5750                 5755                 5760             


Asp Asp  Asp Val Ala Met Cys  Phe Ile Lys Asn Gln  Ala Ala Phe 
    5765                 5770                 5775             


Glu Gln  Tyr Leu Glu Phe Leu  Val Gly Arg Val Gln  Ala Glu Ser 
    5780                 5785                 5790             


Val Val  Val Ser Thr Ala Ile  Gln Glu Phe Tyr Lys  Lys Tyr Ala 
    5795                 5800                 5805             


Glu Glu  Ala Leu Leu Ala Gly  Asp Pro Ser Gln Pro  Pro Pro Pro 
    5810                 5815                 5820             


Pro Leu  Gln His Tyr Leu Glu  Gln Pro Val Glu Arg  Val Gln Arg 
    5825                 5830                 5835             


Tyr Gln  Ala Leu Leu Lys Glu  Leu Ile Arg Asn Lys  Ala Arg Asn 
    5840                 5845                 5850             


Arg Gln  Asn Cys Ala Leu Leu  Glu Gln Ala Tyr Ala  Val Val Ser 
    5855                 5860                 5865             


Ala Leu  Pro Gln Arg Ala Glu  Asn Lys Leu His Val  Ser Leu Met 
    5870                 5875                 5880             


Glu Asn  Tyr Pro Gly Thr Leu  Gln Ala Leu Gly Glu  Pro Ile Arg 
    5885                 5890                 5895             


Gln Gly  His Phe Ile Val Trp  Glu Gly Ala Pro Gly  Ala Arg Met 
    5900                 5905                 5910             


Pro Trp  Lys Gly His Asn Arg  His Val Phe Leu Phe  Arg Asn His 
    5915                 5920                 5925             


Leu Val  Ile Cys Lys Pro Arg  Arg Asp Ser Arg Thr  Asp Thr Val 
    5930                 5935                 5940             


Ser Tyr  Val Phe Arg Asn Met  Met Lys Leu Ser Ser  Ile Asp Leu 
    5945                 5950                 5955             


Asn Asp  Gln Val Glu Gly Asp  Asp Arg Ala Phe Glu  Val Trp Gln 
    5960                 5965                 5970             


Glu Arg  Glu Asp Ser Val Arg  Lys Tyr Leu Leu Gln  Ala Arg Thr 
    5975                 5980                 5985             


Ala Ile  Ile Lys Ser Ser Trp  Val Lys Glu Ile Cys  Gly Ile Gln 
    5990                 5995                 6000             


Gln Arg  Leu Ala Leu Pro Val  Trp Arg Pro Pro Asp  Phe Glu Glu 
    6005                 6010                 6015             


Glu Leu  Ala Asp Cys Thr Ala  Glu Leu Gly Glu Thr  Val Lys Leu 
    6020                 6025                 6030             


Ala Cys  Arg Val Thr Gly Thr  Pro Lys Pro Val Ile  Ser Trp Tyr 
    6035                 6040                 6045             


Lys Asp  Gly Lys Ala Val Gln  Val Asp Pro His His  Ile Leu Ile 
    6050                 6055                 6060             


Glu Asp  Pro Asp Gly Ser Cys  Ala Leu Ile Leu Asp  Ser Leu Thr 
    6065                 6070                 6075             


Gly Val  Asp Ser Gly Gln Tyr  Met Cys Phe Ala Ala  Ser Ala Ala 
    6080                 6085                 6090             


Gly Asn  Cys Ser Thr Leu Gly  Lys Ile Leu Val Gln  Val Pro Pro 
    6095                 6100                 6105             


Arg Phe  Val Asn Lys Val Arg  Ala Ser Pro Phe Val  Glu Gly Glu 
    6110                 6115                 6120             


Asp Ala  Gln Phe Thr Cys Thr  Ile Glu Gly Ala Pro  Tyr Pro Gln 
    6125                 6130                 6135             


Ile Arg  Trp Tyr Lys Asp Gly  Ala Leu Leu Thr Thr  Gly Asn Lys 
    6140                 6145                 6150             


Phe Gln  Thr Leu Ser Glu Pro  Arg Ser Gly Leu Leu  Val Leu Val 
    6155                 6160                 6165             


Ile Arg  Ala Ala Ser Lys Glu  Asp Leu Gly Leu Tyr  Glu Cys Glu 
    6170                 6175                 6180             


Leu Val  Asn Arg Leu Gly Ser  Ala Arg Ala Ser Ala  Glu Leu Arg 
    6185                 6190                 6195             


Ile Gln  Ser Pro Met Leu Gln  Ala Gln Glu Gln Cys  His Arg Glu 
    6200                 6205                 6210             


Gln Leu  Val Ala Ala Val Glu  Asp Thr Thr Leu Glu  Arg Ala Asp 
    6215                 6220                 6225             


Gln Glu  Val Thr Ser Val Leu  Lys Arg Leu Leu Gly  Pro Lys Ala 
    6230                 6235                 6240             


Pro Gly  Pro Ser Thr Gly Asp  Leu Thr Gly Pro Gly  Pro Cys Pro 
    6245                 6250                 6255             


Arg Gly  Ala Pro Ala Leu Gln  Glu Thr Gly Ser Gln  Pro Pro Val 
    6260                 6265                 6270             


Thr Gly  Thr Ser Glu Ala Pro  Ala Val Pro Pro Arg  Val Pro Gln 
    6275                 6280                 6285             


Pro Leu  Leu His Glu Gly Pro  Glu Gln Glu Pro Glu  Ala Ile Ala 
    6290                 6295                 6300             


Arg Ala  Gln Glu Trp Thr Val  Pro Ile Arg Met Glu  Gly Ala Ala 
    6305                 6310                 6315             


Trp Pro  Gly Ala Gly Thr Gly  Glu Leu Leu Trp Asp  Val His Ser 
    6320                 6325                 6330             


His Val  Val Arg Glu Thr Thr  Gln Arg Thr Tyr Thr  Tyr Gln Ala 
    6335                 6340                 6345             


Ile Asp  Thr His Thr Ala Arg  Pro Pro Ser Met Gln  Val Thr Ile 
    6350                 6355                 6360             


Glu Asp  Val Gln Ala Gln Thr  Gly Gly Thr Ala Gln  Phe Glu Ala 
    6365                 6370                 6375             


Ile Ile  Glu Gly Asp Pro Gln  Pro Ser Val Thr Trp  Tyr Lys Asp 
    6380                 6385                 6390             


Ser Val  Gln Leu Val Asp Ser  Thr Arg Leu Ser Gln  Gln Gln Glu 
    6395                 6400                 6405             


Gly Thr  Thr Tyr Ser Leu Val  Leu Arg His Val Ala  Ser Lys Asp 
    6410                 6415                 6420             


Ala Gly  Val Tyr Thr Cys Leu  Ala Gln Asn Thr Gly  Gly Gln Val 
    6425                 6430                 6435             


Leu Cys  Lys Ala Glu Leu Leu  Val Leu Gly Gly Asp  Asn Glu Pro 
    6440                 6445                 6450             


Asp Ser  Glu Lys Gln Ser His  Arg Arg Lys Leu His  Ser Phe Tyr 
    6455                 6460                 6465             


Glu Val  Lys Glu Glu Ile Gly  Arg Gly Val Phe Gly  Phe Val Lys 
    6470                 6475                 6480             


Arg Val  Gln His Lys Gly Asn  Lys Ile Leu Cys Ala  Ala Lys Phe 
    6485                 6490                 6495             


Ile Pro  Leu Arg Ser Arg Thr  Arg Ala Gln Ala Tyr  Arg Glu Arg 
    6500                 6505                 6510             


Asp Ile  Leu Ala Ala Leu Ser  His Pro Leu Val Thr  Gly Leu Leu 
    6515                 6520                 6525             


Asp Gln  Phe Glu Thr Arg Lys  Thr Leu Ile Leu Ile  Leu Glu Leu 
    6530                 6535                 6540             


Cys Ser  Ser Glu Glu Leu Leu  Asp Arg Leu Tyr Arg  Lys Gly Val 
    6545                 6550                 6555             


Val Thr  Glu Ala Glu Val Lys  Val Tyr Ile Gln Gln  Leu Val Glu 
    6560                 6565                 6570             


Gly Leu  His Tyr Leu His Ser  His Gly Val Leu His  Leu Asp Ile 
    6575                 6580                 6585             


Lys Pro  Ser Asn Ile Leu Met  Val His Pro Ala Arg  Glu Asp Ile 
    6590                 6595                 6600             


Lys Ile  Cys Asp Phe Gly Phe  Ala Gln Asn Ile Thr  Pro Ala Glu 
    6605                 6610                 6615             


Leu Gln  Phe Ser Gln Tyr Gly  Ser Pro Glu Phe Val  Ser Pro Glu 
    6620                 6625                 6630             


Ile Ile  Gln Gln Asn Pro Val  Ser Glu Ala Ser Asp  Ile Trp Ala 
    6635                 6640                 6645             


Met Gly  Val Ile Ser Tyr Leu  Ser Leu Thr Cys Ser  Ser Pro Phe 
    6650                 6655                 6660             


Ala Gly  Glu Ser Asp Arg Ala  Thr Leu Leu Asn Val  Leu Glu Gly 
    6665                 6670                 6675             


Arg Val  Ser Trp Ser Ser Pro  Met Ala Ala His Leu  Ser Glu Asp 
    6680                 6685                 6690             


Ala Lys  Asp Phe Ile Lys Ala  Thr Leu Gln Arg Ala  Pro Gln Ala 
    6695                 6700                 6705             


Arg Pro  Ser Ala Ala Gln Cys  Leu Ser His Pro Trp  Phe Leu Lys 
    6710                 6715                 6720             


Ser Met  Pro Ala Glu Glu Ala  His Phe Ile Asn Thr  Lys Gln Leu 
    6725                 6730                 6735             


Lys Phe  Leu Leu Ala Arg Ser  Arg Trp Gln Arg Ser  Leu Met Ser 
    6740                 6745                 6750             


Tyr Lys  Ser Ile Leu Val Met  Arg Ser Ile Pro Glu  Leu Leu Arg 
    6755                 6760                 6765             


Gly Pro  Pro Asp Ser Pro Ser  Leu Gly Val Ala Arg  His Leu Cys 
    6770                 6775                 6780             


Arg Asp  Thr Gly Gly Ser Ser  Ser Ser Ser Ser Ser  Ser Asp Asn 
    6785                 6790                 6795             


Glu Leu  Ala Pro Phe Ala Arg  Ala Lys Ser Leu Pro  Pro Ser Pro 
    6800                 6805                 6810             


Val Thr  His Ser Pro Leu Leu  His Pro Arg Gly Phe  Leu Arg Pro 
    6815                 6820                 6825             


Ser Ala  Ser Leu Pro Glu Glu  Ala Glu Ala Ser Glu  Arg Ser Thr 
    6830                 6835                 6840             


Glu Ala  Pro Ala Pro Pro Ala  Ser Pro Glu Gly Ala  Gly Pro Pro 
    6845                 6850                 6855             


Ala Ala  Gln Gly Cys Val Pro  Arg His Ser Val Ile  Arg Ser Leu 
    6860                 6865                 6870             


Phe Tyr  His Gln Ala Gly Glu  Ser Pro Glu His Gly  Ala Leu Ala 
    6875                 6880                 6885             


Pro Gly  Ser Arg Arg His Pro  Ala Arg Arg Arg His  Leu Leu Lys 
    6890                 6895                 6900             


Gly Gly  Tyr Ile Ala Gly Ala  Leu Pro Gly Leu Arg  Glu Pro Leu 
    6905                 6910                 6915             


Met Glu  His Arg Val Leu Glu  Glu Glu Ala Ala Arg  Glu Glu Gln 
    6920                 6925                 6930             


Ala Thr  Leu Leu Ala Lys Ala  Pro Ser Phe Glu Thr  Ala Leu Arg 
    6935                 6940                 6945             


Leu Pro  Ala Ser Gly Thr His  Leu Ala Pro Gly His  Ser His Ser 
    6950                 6955                 6960             


Leu Glu  His Asp Ser Pro Ser  Thr Pro Arg Pro Ser  Ser Glu Ala 
    6965                 6970                 6975             


Cys Gly  Glu Ala Gln Arg Leu  Pro Ser Ala Pro Ser  Gly Gly Ala 
    6980                 6985                 6990             


Pro Ile  Arg Asp Met Gly His  Pro Gln Gly Ser Lys  Gln Leu Pro 
    6995                 7000                 7005             


Ser Thr  Gly Gly His Pro Gly  Thr Ala Gln Pro Glu  Arg Pro Ser 
    7010                 7015                 7020             


Pro Asp  Ser Pro Trp Gly Gln  Pro Ala Pro Phe Cys  His Pro Lys 
    7025                 7030                 7035             


Gln Gly  Ser Ala Pro Gln Glu  Gly Cys Ser Pro His  Pro Ala Val 
    7040                 7045                 7050             


Ala Pro  Cys Pro Pro Gly Ser  Phe Pro Pro Gly Ser  Cys Lys Glu 
    7055                 7060                 7065             


Ala Pro  Leu Val Pro Ser Ser  Pro Phe Leu Gly Gln  Pro Gln Ala 
    7070                 7075                 7080             


Pro Pro  Ala Pro Ala Lys Ala  Ser Pro Pro Leu Asp  Ser Lys Met 
    7085                 7090                 7095             


Gly Pro  Gly Asp Ile Ser Leu  Pro Gly Arg Pro Lys  Pro Gly Pro 
    7100                 7105                 7110             


Cys Ser  Ser Pro Gly Ser Ala  Ser Gln Ala Ser Ser  Ser Gln Val 
    7115                 7120                 7125             


Ser Ser  Leu Arg Val Gly Ser  Ser Gln Val Gly Thr  Glu Pro Gly 
    7130                 7135                 7140             


Pro Ser  Leu Asp Ala Glu Gly  Trp Thr Gln Glu Ala  Glu Asp Leu 
    7145                 7150                 7155             


Ser Asp  Ser Thr Pro Thr Leu  Gln Arg Pro Gln Glu  Gln Ala Thr 
    7160                 7165                 7170             


Met Arg  Lys Phe Ser Leu Gly  Gly Arg Gly Gly Tyr  Ala Gly Val 
    7175                 7180                 7185             


Ala Gly  Tyr Gly Thr Phe Ala  Phe Gly Gly Asp Ala  Gly Gly Met 
    7190                 7195                 7200             


Leu Gly  Gln Gly Pro Met Trp  Ala Arg Ile Ala Trp  Ala Val Ser 
    7205                 7210                 7215             


Gln Ser  Glu Glu Glu Glu Gln  Glu Glu Ala Arg Ala  Glu Ser Gln 
    7220                 7225                 7230             


Ser Glu  Glu Gln Gln Glu Ala  Arg Ala Glu Ser Pro  Leu Pro Gln 
    7235                 7240                 7245             


Val Ser  Ala Arg Pro Val Pro  Glu Val Gly Arg Ala  Pro Thr Arg 
    7250                 7255                 7260             


Ser Ser  Pro Glu Pro Thr Pro  Trp Glu Asp Ile Gly  Gln Val Ser 
    7265                 7270                 7275             


Leu Val  Gln Ile Arg Asp Leu  Ser Gly Asp Ala Glu  Ala Ala Asp 
    7280                 7285                 7290             


Thr Ile  Ser Leu Asp Ile Ser  Glu Val Asp Pro Ala  Tyr Leu Asn 
    7295                 7300                 7305             


Leu Ser  Asp Leu Tyr Asp Ile  Lys Tyr Leu Pro Phe  Glu Phe Met 
    7310                 7315                 7320             


Ile Phe  Arg Lys Val Pro Lys  Ser Ala Gln Pro Glu  Pro Pro Ser 
    7325                 7330                 7335             


Pro Met  Ala Glu Glu Glu Leu  Ala Glu Phe Pro Glu  Pro Thr Trp 
    7340                 7345                 7350             


Pro Trp  Pro Gly Glu Leu Gly  Pro His Ala Gly Leu  Glu Ile Thr 
    7355                 7360                 7365             


Glu Glu  Ser Glu Asp Val Asp  Ala Leu Leu Ala Glu  Ala Ala Val 
    7370                 7375                 7380             


Gly Arg  Lys Arg Lys Trp Ser  Ser Pro Ser Arg Ser  Leu Phe His 
    7385                 7390                 7395             


Phe Pro  Gly Arg His Leu Pro  Leu Asp Glu Pro Ala  Glu Leu Gly 
    7400                 7405                 7410             


Leu Arg  Glu Arg Val Lys Ala  Ser Val Glu His Ile  Ser Arg Ile 
    7415                 7420                 7425             


Leu Lys  Gly Arg Pro Glu Gly  Leu Glu Lys Glu Gly  Pro Pro Arg 
    7430                 7435                 7440             


Lys Lys  Pro Gly Leu Ala Ser  Phe Arg Leu Ser Gly  Leu Lys Ser 
    7445                 7450                 7455             


Trp Asp  Arg Ala Pro Thr Phe  Leu Arg Glu Leu Ser  Asp Glu Thr 
    7460                 7465                 7470             


Val Val  Leu Gly Gln Ser Val  Thr Leu Ala Cys Gln  Val Ser Ala 
    7475                 7480                 7485             


Gln Pro  Ala Ala Gln Ala Thr  Trp Ser Lys Asp Gly  Ala Pro Leu 
    7490                 7495                 7500             


Glu Ser  Ser Ser Arg Val Leu  Ile Ser Ala Thr Leu  Lys Asn Phe 
    7505                 7510                 7515             


Gln Leu  Leu Thr Ile Leu Val  Val Val Ala Glu Asp  Leu Gly Val 
    7520                 7525                 7530             


Tyr Thr  Cys Ser Val Ser Asn  Ala Leu Gly Thr Val  Thr Thr Thr 
    7535                 7540                 7545             


Gly Val  Leu Arg Lys Ala Glu  Arg Pro Ser Ser Ser  Pro Cys Pro 
    7550                 7555                 7560             


Asp Ile  Gly Glu Val Tyr Ala  Asp Gly Val Leu Leu  Val Trp Lys 
    7565                 7570                 7575             


Pro Val  Glu Ser Tyr Gly Pro  Val Thr Tyr Ile Val  Gln Cys Ser 
    7580                 7585                 7590             


Leu Glu  Gly Gly Ser Trp Thr  Thr Leu Ala Ser Asp  Ile Phe Asp 
    7595                 7600                 7605             


Cys Cys  Tyr Leu Thr Ser Lys  Leu Ser Arg Gly Gly  Thr Tyr Thr 
    7610                 7615                 7620             


Phe Arg  Thr Ala Cys Val Ser  Lys Ala Gly Met Gly  Pro Tyr Ser 
    7625                 7630                 7635             


Ser Pro  Ser Glu Gln Val Leu  Leu Gly Gly Pro Ser  His Leu Ala 
    7640                 7645                 7650             


Ser Glu  Glu Glu Ser Gln Gly  Arg Ser Ala Gln Pro  Leu Pro Ser 
    7655                 7660                 7665             


Thr Lys  Thr Phe Ala Phe Gln  Thr Gln Ile Gln Arg  Gly Arg Phe 
    7670                 7675                 7680             


Ser Val  Val Arg Gln Cys Trp  Glu Lys Ala Ser Gly  Arg Ala Leu 
    7685                 7690                 7695             


Ala Ala  Lys Ile Ile Pro Tyr  His Pro Lys Asp Lys  Thr Ala Val 
    7700                 7705                 7710             


Leu Arg  Glu Tyr Glu Ala Leu  Lys Gly Leu Arg His  Pro His Leu 
    7715                 7720                 7725             


Ala Gln  Leu His Ala Ala Tyr  Leu Ser Pro Arg His  Leu Val Leu 
    7730                 7735                 7740             


Ile Leu  Glu Leu Cys Ser Gly  Pro Glu Leu Leu Pro  Cys Leu Ala 
    7745                 7750                 7755             


Glu Arg  Ala Ser Tyr Ser Glu  Ser Glu Val Lys Asp  Tyr Leu Trp 
    7760                 7765                 7770             


Gln Met  Leu Ser Ala Thr Gln  Tyr Leu His Asn Gln  His Ile Leu 
    7775                 7780                 7785             


His Leu  Asp Leu Arg Ser Glu  Asn Met Ile Ile Thr  Glu Tyr Asn 
    7790                 7795                 7800             


Leu Leu  Lys Val Val Asp Leu  Gly Asn Ala Gln Ser  Leu Ser Gln 
    7805                 7810                 7815             


Glu Lys  Val Leu Pro Ser Asp  Lys Phe Lys Asp Tyr  Leu Glu Thr 
    7820                 7825                 7830             


Met Ala  Pro Glu Leu Leu Glu  Gly Gln Gly Ala Val  Pro Gln Thr 
    7835                 7840                 7845             


Asp Ile  Trp Ala Ile Gly Val  Thr Ala Phe Ile Met  Leu Ser Ala 
    7850                 7855                 7860             


Glu Tyr  Pro Val Ser Ser Glu  Gly Ala Arg Asp Leu  Gln Arg Gly 
    7865                 7870                 7875             


Leu Arg  Lys Gly Leu Val Arg  Leu Ser Arg Cys Tyr  Ala Gly Leu 
    7880                 7885                 7890             


Ser Gly  Gly Ala Val Ala Phe  Leu Arg Ser Thr Leu  Cys Ala Gln 
    7895                 7900                 7905             


Pro Trp  Gly Arg Pro Cys Ala  Ser Ser Cys Leu Gln  Cys Pro Trp 
    7910                 7915                 7920             


Leu Thr  Glu Glu Gly Pro Ala  Cys Ser Arg Pro Ala  Pro Val Thr 
    7925                 7930                 7935             


Phe Pro  Thr Ala Arg Leu Arg  Val Phe Val Arg Asn  Arg Glu Lys 
    7940                 7945                 7950             


Arg Arg  Ala Leu Leu Tyr Lys  Arg His Asn Leu Ala  Gln Val Arg 
    7955                 7960                 7965             


<210> 7431
<211> 249
<212> PRT
<213> Homo sapiens

<400> 7431
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn 
145                 150                 155                 160 


Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala 
                165                 170                 175     


Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu 
            180                 185                 190         


Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys 
        195                 200                 205             


Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp 
    210                 215                 220                 


Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val 
225                 230                 235                 240 


Glu Ile Leu Leu Thr Phe Lys Ile Lys 
                245                 


<210> 7432
<211> 138
<212> PRT
<213> Homo sapiens

<400> 7432
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn 
    130                 135             


<210> 7433
<211> 373
<212> PRT
<213> Homo sapiens

<400> 7433
Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Tyr Ile Val Lys Cys 
        115                 120                 125             


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
    130                 135                 140                 


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
145                 150                 155                 160 


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
                165                 170                 175     


Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu 
            180                 185                 190         


Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu 
        195                 200                 205             


Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe 
    210                 215                 220                 


Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His 
225                 230                 235                 240 


Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu 
                245                 250                 255     


Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala 
            260                 265                 270         


Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile 
        275                 280                 285             


His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp 
    290                 295                 300                 


Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr 
305                 310                 315                 320 


Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys 
                325                 330                 335     


Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile 
            340                 345                 350         


Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile 
        355                 360                 365             


Thr Asn Ile Phe Ala 
    370             


<210> 7434
<211> 182
<212> PRT
<213> Homo sapiens

<400> 7434
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Phe Pro 
        35                  40                  45              


Ile Ser Lys Pro Asp Gly Ile Ser Gln Leu Glu Gln Asp Leu Gln Val 
    50                  55                  60                  


Phe Asp Leu Glu Thr Lys Thr Arg Glu Val Leu Arg Asp Asp Cys Ser 
65                  70                  75                  80  


Asp Gly Glu Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys 
                85                  90                  95      


Ile Ser Glu Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys 
            100                 105                 110         


His Asp Ile Thr Gln Val Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu 
        115                 120                 125             


Asp Arg Leu Glu Arg Leu Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu 
    130                 135                 140                 


Glu Arg Glu Phe Arg Gln Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser 
145                 150                 155                 160 


Glu Lys Asn Asn Glu Cys His Glu Pro Glu Lys Ser Phe Ser Leu Asp 
                165                 170                 175     


Ser Thr Ile Asp Ala Asp 
            180         


<210> 7435
<211> 750
<212> PRT
<213> Homo sapiens

<400> 7435
Met Ser Leu Gly Lys Ala Tyr Gly Val Glu Ser His Val Leu Ser Pro 
1               5                   10                  15      


Ala Glu Thr Lys Thr Leu Tyr Pro Leu Met Asn Val Asp Asp Leu Tyr 
            20                  25                  30          


Gly Thr Leu Tyr Val Pro His Asp Gly Thr Met Asp Pro Ala Gly Thr 
        35                  40                  45              


Cys Thr Thr Leu Ala Arg Ala Ala Ser Ala Arg Gly Ala Gln Val Ile 
    50                  55                  60                  


Glu Asn Cys Pro Val Thr Gly Ile Arg Val Trp Thr Asp Asp Phe Gly 
65                  70                  75                  80  


Val Arg Arg Val Ala Gly Val Glu Thr Gln His Gly Ser Ile Gln Thr 
                85                  90                  95      


Pro Cys Val Val Asn Cys Ala Gly Val Trp Ala Ser Ala Val Gly Arg 
            100                 105                 110         


Met Ala Gly Val Lys Val Pro Leu Val Ala Met His His Ala Tyr Val 
        115                 120                 125             


Val Thr Glu Arg Ile Glu Gly Ile Gln Asn Met Pro Asn Val Arg Asp 
    130                 135                 140                 


His Asp Ala Ser Val Tyr Leu Arg Leu Gln Gly Asp Ala Leu Ser Val 
145                 150                 155                 160 


Gly Gly Tyr Glu Ala Asn Pro Ile Phe Trp Glu Glu Val Ser Asp Lys 
                165                 170                 175     


Phe Ala Phe Gly Leu Phe Asp Leu Asp Trp Glu Val Phe Thr Gln His 
            180                 185                 190         


Ile Glu Gly Ala Ile Asn Arg Val Pro Val Leu Glu Lys Thr Gly Ile 
        195                 200                 205             


Lys Ser Thr Val Cys Gly Pro Glu Ser Phe Thr Pro Asp His Lys Pro 
    210                 215                 220                 


Leu Met Gly Glu Ala Pro Glu Leu Arg Gly Phe Phe Leu Gly Cys Gly 
225                 230                 235                 240 


Phe Asn Ser Ala Gly Met Met Leu Gly Gly Gly Cys Gly Gln Glu Leu 
                245                 250                 255     


Ala His Trp Ile Ile His Gly Arg Pro Glu Lys Asp Met His Gly Tyr 
            260                 265                 270         


Asp Ile Arg Arg Phe His His Ser Leu Thr Asp His Pro Arg Trp Ile 
        275                 280                 285             


Arg Glu Arg Ser His Glu Ser Tyr Ala Lys Asn Tyr Ser Val Val Phe 
    290                 295                 300                 


Pro His Asp Glu Pro Leu Ala Gly Arg Asn Met Arg Arg Asp Pro Leu 
305                 310                 315                 320 


His Glu Glu Leu Leu Gly Gln Gly Cys Val Phe Gln Glu Arg His Gly 
                325                 330                 335     


Trp Glu Arg Pro Gly Trp Phe His Pro Arg Gly Pro Ala Pro Val Leu 
            340                 345                 350         


Glu Tyr Asp Tyr Tyr Gly Ala Tyr Gly Ser Arg Ala His Glu Asp Tyr 
        355                 360                 365             


Ala Tyr Arg Arg Leu Leu Ala Asp Glu Tyr Thr Phe Ala Phe Pro Pro 
    370                 375                 380                 


His His Asp Thr Ile Lys Lys Glu Cys Leu Ala Cys Arg Gly Ala Ala 
385                 390                 395                 400 


Ala Val Phe Asp Met Ser Tyr Phe Gly Lys Phe Tyr Leu Val Gly Leu 
                405                 410                 415     


Asp Ala Arg Lys Ala Ala Asp Trp Leu Phe Ser Ala Asp Val Ser Arg 
            420                 425                 430         


Pro Pro Gly Ser Thr Val Tyr Thr Cys Met Leu Asn His Arg Gly Gly 
        435                 440                 445             


Thr Glu Ser Asp Leu Thr Val Ser Arg Leu Ala Pro Ser His Gln Ala 
    450                 455                 460                 


Ser Pro Leu Ala Pro Ala Phe Glu Gly Asp Gly Tyr Tyr Leu Ala Met 
465                 470                 475                 480 


Gly Gly Ala Val Ala Gln His Asn Trp Ser His Ile Thr Thr Val Leu 
                485                 490                 495     


Gln Asp Gln Lys Ser Gln Cys Gln Leu Ile Asp Ser Ser Glu Asp Leu 
            500                 505                 510         


Gly Met Ile Ser Ile Gln Gly Pro Ala Ser Arg Ala Ile Leu Gln Glu 
        515                 520                 525             


Val Leu Asp Ala Asp Leu Ser Asn Glu Ala Phe Pro Phe Ser Thr His 
    530                 535                 540                 


Lys Leu Leu Arg Ala Ala Gly His Leu Val Arg Ala Met Arg Leu Ser 
545                 550                 555                 560 


Phe Val Gly Glu Leu Gly Trp Glu Leu His Ile Pro Lys Ala Ser Cys 
                565                 570                 575     


Val Pro Val Tyr Arg Ala Val Met Ala Ala Gly Ala Lys His Gly Leu 
            580                 585                 590         


Ile Asn Ala Gly Tyr Arg Ala Ile Asp Ser Leu Ser Ile Glu Lys Gly 
        595                 600                 605             


Tyr Arg His Trp His Ala Asp Leu Arg Pro Asp Asp Ser Pro Leu Glu 
    610                 615                 620                 


Ala Gly Leu Ala Phe Thr Cys Lys Leu Lys Ser Pro Val Pro Phe Leu 
625                 630                 635                 640 


Gly Arg Glu Ala Leu Glu Gln Gln Arg Ala Ala Gly Leu Arg Arg Arg 
                645                 650                 655     


Leu Val Cys Phe Thr Met Glu Asp Lys Val Pro Met Phe Gly Leu Glu 
            660                 665                 670         


Ala Ile Trp Arg Asn Gly Gln Val Val Gly His Val Arg Arg Ala Asp 
        675                 680                 685             


Phe Gly Phe Ala Ile Asp Lys Thr Ile Ala Tyr Gly Tyr Ile His Asp 
    690                 695                 700                 


Pro Ser Gly Gly Pro Val Ser Leu Asp Phe Val Lys Ser Gly Asp Tyr 
705                 710                 715                 720 


Ala Leu Glu Arg Met Gly Val Thr Tyr Gly Ala Gln Ala His Leu Lys 
                725                 730                 735     


Ser Pro Phe Asp Pro Asn Asn Lys Arg Val Lys Gly Ile Tyr 
            740                 745                 750 


<210> 7436
<211> 152
<212> PRT
<213> Homo sapiens

<400> 7436
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val 
145                 150         


<210> 7437
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7437
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7438
<211> 421
<212> PRT
<213> Homo sapiens

<400> 7438
Met Met Glu Asp Asn Lys Gln Leu Ala Leu Arg Ile Asp Gly Ala Val 
1               5                   10                  15      


Gln Ser Ala Ser Gln Glu Val Thr Asn Leu Arg Ala Glu Leu Thr Ala 
            20                  25                  30          


Thr Asn Arg Arg Leu Ala Glu Leu Ser Gly Gly Gly Gly Pro Gly Pro 
        35                  40                  45              


Gly Pro Gly Ala Ala Ala Ser Ala Ser Ala Ala Gly Asp Ser Ala Ala 
    50                  55                  60                  


Thr Asn Met Glu Asn Pro Gln Leu Gly Ala Gln Val Leu Leu Arg Glu 
65                  70                  75                  80  


Glu Val Ser Arg Leu Gln Glu Glu Val His Leu Leu Arg Gln Met Lys 
                85                  90                  95      


Glu Met Leu Ala Lys Asp Leu Glu Glu Ser Gln Gly Gly Lys Ser Ser 
            100                 105                 110         


Glu Val Leu Ser Ala Thr Glu Leu Arg Val Gln Leu Ala Gln Lys Glu 
        115                 120                 125             


Gln Glu Leu Ala Arg Ala Lys Glu Ala Leu Gln Ala Met Lys Ala Asp 
    130                 135                 140                 


Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln Met Gln 
145                 150                 155                 160 


Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg Asp Phe 
                165                 170                 175     


Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala Val Lys 
            180                 185                 190         


Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp Glu Leu 
        195                 200                 205             


Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu Arg Ser 
    210                 215                 220                 


Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val Pro Lys 
                245                 250                 255     


Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu Asn Gly Asn Gln 
            260                 265                 270         


Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala Ala Ile Arg Gln 
        275                 280                 285             


Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His Pro Ala Asp Arg 
    290                 295                 300                 


Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln Pro Ser Val Ile 
305                 310                 315                 320 


Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser Thr Pro Ser Asp 
                325                 330                 335     


Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys Asn Gly Asp Ser 
            340                 345                 350         


Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro Ile Val Gln Ser Leu 
        355                 360                 365             


Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys Glu Lys Met Gly 
    370                 375                 380                 


Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly Lys Gln Arg Lys Ser 
385                 390                 395                 400 


Leu Asp Pro Gly Leu Phe Asp Gly Thr Ala Pro Asp Tyr Tyr Ile Glu 
                405                 410                 415     


Glu Asp Ala Asp Trp 
            420     


<210> 7439
<211> 163
<212> PRT
<213> Homo sapiens

<400> 7439
Met Val Gly Gly Gly Gly Val Gly Gly Gly Leu Leu Glu Asn Ala Asn 
1               5                   10                  15      


Pro Leu Ile Tyr Gln Arg Ser Gly Glu Arg Pro Val Thr Ala Gly Glu 
            20                  25                  30          


Glu Asp Glu Gln Val Pro Asp Ser Ile Asp Ala Arg Glu Ile Phe Asp 
        35                  40                  45              


Leu Ile Arg Ser Ile Asn Asp Pro Glu His Pro Leu Thr Leu Glu Glu 
    50                  55                  60                  


Leu Asn Val Val Glu Gln Val Arg Val Gln Val Ser Asp Pro Glu Ser 
65                  70                  75                  80  


Thr Val Ala Val Ala Phe Thr Pro Thr Ile Pro His Cys Ser Met Ala 
                85                  90                  95      


Thr Leu Ile Gly Leu Ser Ile Lys Val Lys Leu Leu Arg Ser Leu Pro 
            100                 105                 110         


Gln Arg Phe Lys Met Asp Val His Ile Thr Pro Gly Thr His Ala Ser 
        115                 120                 125             


Glu His Ala Val Asn Lys Gln Leu Ala Asp Lys Glu Arg Val Ala Ala 
    130                 135                 140                 


Ala Leu Glu Asn Thr His Leu Leu Glu Val Val Asn Gln Cys Leu Ser 
145                 150                 155                 160 


Ala Arg Ser 
            


<210> 7440
<211> 68
<212> PRT
<213> Homo sapiens

<400> 7440
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu 
65              


<210> 7441
<211> 177
<212> PRT
<213> Homo sapiens

<400> 7441
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly 
65                  70                  75                  80  


Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln 
                85                  90                  95      


Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp 
            100                 105                 110         


His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile 
        115                 120                 125             


Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly 
    130                 135                 140                 


His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg 
145                 150                 155                 160 


Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr 
                165                 170                 175     


Ala 
    


<210> 7442
<211> 142
<212> PRT
<213> Homo sapiens

<400> 7442
Met Thr Gln Leu Arg Gln Val Leu Glu Ser Arg Leu Gln Arg Pro Leu 
1               5                   10                  15      


Pro Glu Asp Leu Ala Arg Leu Trp Pro Val Val Ile Leu Cys Gln Leu 
            20                  25                  30          


Ala Asn Gln Leu Arg Pro Arg Ser Val Pro Phe Ile His Val Pro Ser 
        35                  40                  45              


Pro Ala Val Pro Lys Leu Ser Ala Leu Lys Ala Arg Lys Asn Val Glu 
    50                  55                  60                  


Ser Phe Leu Glu Ala Cys Arg Lys Met Gly Val Pro Glu Ala Asp Leu 
65                  70                  75                  80  


Cys Ser Pro Ser Asp Leu Leu Gln Gly Thr Ala Arg Gly Leu Arg Thr 
                85                  90                  95      


Ala Leu Glu Ala Val Lys Arg Val Gly Gly Lys Ala Leu Pro Pro Leu 
            100                 105                 110         


Trp Pro Pro Ser Gly Leu Gly Gly Phe Val Val Phe Tyr Val Val Leu 
        115                 120                 125             


Met Leu Leu Leu Tyr Val Thr Tyr Thr Arg Leu Leu Gly Ser 
    130                 135                 140         


<210> 7443
<211> 431
<212> PRT
<213> Homo sapiens

<400> 7443
Met Glu Asp Leu Lys Gly Pro Thr Val Ser Ser Phe Leu Ser Gly Met 
1               5                   10                  15      


Lys Thr Glu Leu Tyr Pro Gly Val Thr Ala Ile Asp Met Met Tyr Lys 
            20                  25                  30          


Glu Gly Leu His Gly Val Asp Asn Gly Ile Leu Ile Phe Asp Lys Val 
        35                  40                  45              


Arg Ile Pro Arg Glu Asn Leu Leu Asp Lys Phe Gly Ser Val Ala Pro 
    50                  55                  60                  


Asp Gly Gln Tyr His Ser Pro Ile Arg Asn Lys Ser Ala Arg Phe Asn 
65                  70                  75                  80  


Ala Met Leu Ala Ala Leu Thr Pro Ser Arg Leu Ala Val Ala Phe Gln 
                85                  90                  95      


Ala Met Gly Ala Met Lys Leu Gly Leu Thr Ile Ala Ile Arg Tyr Ser 
            100                 105                 110         


His Ser Arg Arg Gln Phe Gly Pro Lys Thr Lys Glu Glu Val Lys Ile 
        115                 120                 125             


Ile Glu His Gln Thr Gln Thr Leu Arg Leu Met Pro His Leu Ala Thr 
    130                 135                 140                 


Ala Leu Ala Leu Thr Phe Val Ser Arg Tyr Ala Gly Ala Leu Leu Asp 
145                 150                 155                 160 


Glu Asp Val Phe Gln Gly Lys Glu Leu Val Asn Ser Arg Ser Leu Gln 
                165                 170                 175     


Ala Leu Val Ala Gly Leu Lys Ala Tyr Ser Thr Trp Glu Asn Ile Arg 
            180                 185                 190         


Cys Leu Gln Asp Cys Arg Glu Cys Thr Gly Gly Met Val Val Gly Arg 
        195                 200                 205             


Glu Leu Leu Ala Gln Tyr Thr Lys Gln Tyr Glu Glu Lys Pro Leu Phe 
    210                 215                 220                 


Gly Leu Leu Gln Asn Trp Ala Glu Ser Val Gly Asp Lys Leu Arg Thr 
225                 230                 235                 240 


Ser Phe Leu Ala Phe Asn Met Asp Thr Val Asp Asp Leu Ala Phe Leu 
                245                 250                 255     


Leu Lys Ala Val Lys Phe Arg Glu Arg Val Leu Gln Arg Gly Leu Val 
            260                 265                 270         


Ala Arg Ile Tyr Tyr Lys Val Lys Thr Lys Lys Glu Asp Phe Phe His 
        275                 280                 285             


Ala Trp Asn Ser Cys Leu His His Val Ala Ser Leu Ser Leu Ala His 
    290                 295                 300                 


Thr His Arg Val Thr Leu Glu Gln Phe Ser Leu Ala Val Lys Ser Cys 
305                 310                 315                 320 


Pro Asp Gln Glu Asp Gln Thr Leu Leu Met Lys Phe Cys Leu Leu Tyr 
                325                 330                 335     


Gly Thr Lys Leu Val Phe Gln Glu Arg Ala Trp Tyr Leu Glu His Lys 
            340                 345                 350         


Tyr Leu Thr Pro Met Ala Ser Thr Arg Ile Arg Asn Gln Leu Leu Asp 
        355                 360                 365             


Leu Cys Asp Ser Val Lys Asp Asp Ala Arg Arg Val Ile Ser Thr Phe 
    370                 375                 380                 


Asn Ile Pro His Thr Tyr Leu His Ala Pro Ile Ala Gly Ile Ser Asn 
385                 390                 395                 400 


Pro Arg Ala Ala Trp Ala Phe Tyr Pro Ala Pro Leu Gln Pro Arg Pro 
                405                 410                 415     


Arg Glu Glu Ala Arg Ser Arg Arg Pro Lys Leu Gly Ala Lys Leu 
            420                 425                 430     


<210> 7444
<211> 480
<212> PRT
<213> Homo sapiens

<400> 7444
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Trp Leu Leu Arg Phe Lys 
145                 150                 155                 160 


Val Ser Thr Gln Asn Met Lys Met Gly Gly Leu Pro Arg Thr Thr Pro 
                165                 170                 175     


Pro Thr Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Thr Leu 
            180                 185                 190         


Gly Arg His Ser Pro Tyr Arg Thr Leu Glu Pro Val Arg Pro Pro Val 
        195                 200                 205             


Val Pro Asn Asp Tyr Val Pro Ser Pro Thr Arg Asn Met Ala Pro Ser 
    210                 215                 220                 


Gln Gln Ser Pro Val Arg Thr Ala Ser Val Asn Gln Arg Asn Arg Thr 
225                 230                 235                 240 


Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser 
                245                 250                 255     


Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala 
            260                 265                 270         


Val Pro Thr Pro Ser Pro Pro Ser Val Phe Pro Asp Ala Ala Ala Gly 
        275                 280                 285             


Gly Ala Gln Thr Leu Ala Asp Gly Phe Thr Ser Pro Thr Pro Pro Val 
    290                 295                 300                 


Val Ser Ser Thr Pro Pro Thr Gly His Pro Val Gln Phe Tyr Ser Met 
305                 310                 315                 320 


Asn Arg Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser Leu 
                325                 330                 335     


Pro Tyr Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln Asn 
            340                 345                 350         


Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp Thr 
        355                 360                 365             


Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val 
385                 390                 395                 400 


Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro 
                405                 410                 415     


Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp 
            420                 425                 430         


Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile 
        435                 440                 445             


Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Met Asn Gly Val Thr 
    450                 455                 460                 


Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
465                 470                 475                 480 


<210> 7445
<211> 1033
<212> PRT
<213> Homo sapiens

<400> 7445
Met Asp Glu Glu Glu Asn His Tyr Val Ser Gln Leu Arg Glu Val Tyr 
1               5                   10                  15      


Ser Ser Cys Asp Thr Thr Gly Thr Gly Phe Leu Asp Arg Gln Glu Leu 
            20                  25                  30          


Thr Gln Leu Cys Leu Lys Leu His Leu Glu Gln Gln Leu Pro Val Leu 
        35                  40                  45              


Leu Gln Thr Leu Leu Gly Asn Asp His Phe Ala Arg Val Asn Phe Glu 
    50                  55                  60                  


Glu Phe Lys Glu Gly Phe Val Ala Val Leu Ser Ser Asn Ala Gly Val 
65                  70                  75                  80  


Arg Pro Ser Asp Glu Asp Ser Ser Ser Leu Glu Ser Ala Ala Ser Ser 
                85                  90                  95      


Ala Ile Pro Pro Lys Tyr Val Asn Gly Ser Lys Trp Tyr Gly Arg Arg 
            100                 105                 110         


Ser Arg Pro Glu Leu Cys Asp Ala Ala Thr Glu Ala Arg Arg Val Pro 
        115                 120                 125             


Glu Gln Gln Thr Gln Ala Ser Leu Lys Ser His Leu Trp Arg Ser Ala 
    130                 135                 140                 


Ser Leu Glu Ser Val Glu Ser Pro Lys Ser Asp Glu Glu Ala Glu Ser 
145                 150                 155                 160 


Thr Lys Glu Ala Gln Asn Glu Leu Phe Glu Ala Gln Gly Gln Leu Gln 
                165                 170                 175     


Thr Trp Asp Ser Glu Asp Phe Gly Ser Pro Gln Lys Ser Cys Ser Pro 
            180                 185                 190         


Ser Phe Asp Thr Pro Glu Ser Gln Ile Arg Gly Val Trp Glu Glu Leu 
        195                 200                 205             


Gly Val Gly Ser Ser Gly His Leu Ser Glu Gln Glu Leu Ala Val Val 
    210                 215                 220                 


Cys Gln Ser Val Gly Leu Gln Gly Leu Glu Lys Glu Glu Leu Glu Asp 
225                 230                 235                 240 


Leu Phe Asn Lys Leu Asp Gln Asp Gly Asp Gly Lys Val Ser Leu Glu 
                245                 250                 255     


Glu Phe Gln Leu Gly Leu Phe Ser His Glu Pro Ala Leu Leu Leu Glu 
            260                 265                 270         


Ser Ser Thr Arg Val Lys Pro Ser Lys Ala Trp Ser His Tyr Gln Val 
        275                 280                 285             


Pro Glu Glu Ser Gly Cys His Thr Thr Thr Thr Ser Ser Leu Val Ser 
    290                 295                 300                 


Leu Cys Ser Ser Leu Arg Leu Phe Ser Ser Ile Asp Asp Gly Ser Gly 
305                 310                 315                 320 


Phe Ala Phe Pro Asp Gln Val Leu Ala Met Trp Thr Gln Glu Gly Ile 
                325                 330                 335     


Gln Asn Gly Arg Glu Ile Leu Gln Ser Leu Asp Phe Ser Val Asp Glu 
            340                 345                 350         


Lys Val Asn Leu Leu Glu Leu Thr Trp Ala Leu Asp Asn Glu Leu Met 
        355                 360                 365             


Thr Val Asp Ser Ala Val Gln Gln Ala Ala Leu Ala Cys Tyr His Gln 
    370                 375                 380                 


Glu Leu Ser Tyr Gln Gln Gly Gln Val Glu Gln Leu Ala Arg Glu Arg 
385                 390                 395                 400 


Asp Lys Ala Arg Gln Asp Leu Glu Arg Ala Glu Lys Arg Asn Leu Glu 
                405                 410                 415     


Phe Val Lys Glu Met Asp Asp Cys His Ser Thr Leu Glu Gln Leu Thr 
            420                 425                 430         


Glu Lys Lys Ile Lys His Leu Glu Gln Gly Tyr Arg Glu Arg Leu Ser 
        435                 440                 445             


Leu Leu Arg Ser Glu Val Glu Ala Glu Arg Glu Leu Phe Trp Glu Gln 
    450                 455                 460                 


Ala His Arg Gln Arg Ala Ala Leu Glu Trp Asp Val Gly Arg Leu Gln 
465                 470                 475                 480 


Ala Glu Glu Ala Gly Leu Arg Glu Lys Leu Thr Leu Ala Leu Lys Glu 
                485                 490                 495     


Asn Ser Arg Leu Gln Lys Glu Ile Val Glu Val Val Glu Lys Leu Ser 
            500                 505                 510         


Asp Ser Glu Arg Leu Ala Leu Lys Leu Gln Lys Asp Leu Glu Phe Val 
        515                 520                 525             


Leu Lys Asp Lys Leu Glu Pro Gln Ser Ala Glu Leu Leu Ala Gln Glu 
    530                 535                 540                 


Glu Arg Phe Ala Ala Val Leu Lys Glu Tyr Glu Leu Lys Cys Arg Asp 
545                 550                 555                 560 


Leu Gln Asp Arg Asn Asp Glu Leu Gln Ala Glu Leu Glu Gly Leu Trp 
                565                 570                 575     


Ala Arg Leu Pro Lys Asn Arg His Ser Pro Ser Trp Ser Pro Asp Gly 
            580                 585                 590         


Arg Arg Arg Gln Leu Pro Gly Leu Gly Pro Ala Gly Ile Ser Phe Leu 
        595                 600                 605             


Gly Asn Ser Ala Pro Val Ser Ile Glu Thr Glu Leu Met Met Glu Gln 
    610                 615                 620                 


Val Lys Glu His Tyr Gln Asp Leu Arg Thr Gln Leu Glu Thr Lys Val 
625                 630                 635                 640 


Asn Tyr Tyr Glu Arg Glu Ile Ala Ala Leu Lys Arg Asn Phe Glu Lys 
                645                 650                 655     


Glu Arg Lys Asp Met Glu Gln Ala Arg Arg Arg Glu Val Ser Val Leu 
            660                 665                 670         


Glu Gly Gln Lys Ala Asp Leu Glu Glu Leu His Glu Lys Ser Gln Glu 
        675                 680                 685             


Val Ile Trp Gly Leu Gln Glu Gln Leu Gln Asp Thr Ala Arg Gly Pro 
    690                 695                 700                 


Glu Pro Glu Gln Met Gly Leu Ala Pro Cys Cys Thr Gln Ala Leu Cys 
705                 710                 715                 720 


Gly Leu Ala Leu Arg His His Ser His Leu Gln Gln Ile Arg Leu Glu 
                725                 730                 735     


Phe His Arg Leu Ser Glu Glu Asn Thr Leu Leu Lys Asn Asp Leu Gly 
            740                 745                 750         


Arg Val Arg Gln Glu Leu Glu Ala Ala Glu Ser Thr His Asp Ala Gln 
        755                 760                 765             


Arg Lys Glu Ile Glu Val Leu Lys Lys Asp Lys Glu Lys Ala Cys Ser 
    770                 775                 780                 


Glu Met Glu Val Leu Asn Arg Gln Asn Gln Asn Tyr Lys Asp Gln Leu 
785                 790                 795                 800 


Ser Gln Leu Asn Val Arg Val Leu Gln Leu Gly Gln Glu Ala Ser Thr 
                805                 810                 815     


His Gln Ala Gln Asn Glu Glu His Arg Val Thr Ile Gln Met Leu Thr 
            820                 825                 830         


Gln Ser Leu Glu Glu Val Val Arg Ser Gly Gln Gln Gln Ser Asp Gln 
        835                 840                 845             


Ile Gln Lys Leu Arg Val Glu Leu Glu Cys Leu Asn Gln Glu His Gln 
    850                 855                 860                 


Ser Leu Gln Leu Pro Trp Ser Glu Leu Thr Gln Thr Leu Glu Glu Ser 
865                 870                 875                 880 


Gln Asp Gln Val Gln Gly Ala His Leu Arg Leu Arg Gln Ala Gln Ala 
                885                 890                 895     


Gln His Leu Gln Glu Val Arg Leu Val Pro Gln Asp Arg Val Ala Glu 
            900                 905                 910         


Leu His Arg Leu Leu Ser Leu Gln Gly Glu Gln Ala Arg Arg Arg Leu 
        915                 920                 925             


Asp Ala Gln Arg Glu Glu His Glu Lys Gln Leu Lys Ala Thr Glu Glu 
    930                 935                 940                 


Arg Val Glu Glu Ala Glu Met Ile Leu Lys Asn Met Glu Met Leu Leu 
945                 950                 955                 960 


Gln Glu Lys Val Asp Lys Leu Lys Glu Gln Phe Glu Lys Asn Thr Lys 
                965                 970                 975     


Ser Asp Leu Leu Leu Lys Glu Leu Tyr Val Glu Asn Ala His Leu Val 
            980                 985                 990         


Arg Ala Leu Gln Ala Thr Glu Glu  Lys Gln Arg Gly Ala  Glu Lys Gln 
        995                 1000                 1005             


Ser Arg  Leu Leu Glu Glu Lys  Val Arg Ala Leu Asn  Lys Leu Val 
    1010                 1015                 1020             


Ser Arg  Ile Ala Pro Ala Ala  Leu Ser Val 
    1025                 1030             


<210> 7446
<211> 208
<212> PRT
<213> Homo sapiens

<400> 7446
Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly Arg Gly 
1               5                   10                  15      


Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly 
            20                  25                  30          


Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly Gly Cys Gly Ser 
        35                  40                  45              


Gly Cys Ala Gly Cys Gly Gly Cys Lys Gly Gly Cys Gly Ser Cys Gly 
    50                  55                  60                  


Gly Ser Lys Arg Gly Cys Val Ser Cys Gly Val Ser Lys Gly Ala Cys 
65                  70                  75                  80  


Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser 
                85                  90                  95      


Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser 
            100                 105                 110         


Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Tyr Gly Cys Ser Gln Ser 
        115                 120                 125             


Ser Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys 
    130                 135                 140                 


Cys Gln Ser Ser Cys Cys Lys Pro Tyr Cys Cys Gln Ser Ser Cys Cys 
145                 150                 155                 160 


Lys Pro Tyr Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Ser Cys Phe 
                165                 170                 175     


Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser Cys Tyr Lys Pro Cys 
            180                 185                 190         


Cys Cys Gln Ser Ser Cys Cys Val Pro Val Cys Cys Gln Cys Lys Ile 
        195                 200                 205             


<210> 7447
<211> 213
<212> PRT
<213> Homo sapiens

<400> 7447
Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Val Leu Asn Gly Asn Ala Phe Asn Phe Ser 
                165                 170                 175     


Pro Phe Asn Met Met Leu Ala Val Asp Leu Ser Tyr Met Val Phe Ile 
            180                 185                 190         


Thr Ser Ser Pro Ser Tyr Gly Lys Phe Glu Met Gln Arg Gly Asn Ser 
        195                 200                 205             


Ser Lys Gly Asp Gln 
    210             


<210> 7448
<211> 1239
<212> PRT
<213> Homo sapiens

<400> 7448
Met Thr Ile Trp Gln Met Gln Lys Gln Ala Gln Arg Gly Ser Pro Ala 
1               5                   10                  15      


Arg Thr His Ser Met Met Ser Leu Ser Val Arg Pro Gln Arg Arg Leu 
            20                  25                  30          


Leu Ser Ala Arg Val Asn Arg Ser Gln Ser Phe Ala Gly Val Leu Gly 
        35                  40                  45              


Ser His Glu Arg Gly Pro Arg Ser Phe Pro Val Phe Ser Pro Pro Gly 
    50                  55                  60                  


Pro Pro Arg Lys Pro Pro Ala Leu Ser Arg Val Ser Arg Met Phe Ser 
65                  70                  75                  80  


Val Ala His Pro Ala Ala Lys Val Pro Gln Pro Glu Arg Leu Asp Leu 
                85                  90                  95      


Val Tyr Thr Ala Leu Lys Arg Gly Leu Thr Ala Tyr Leu Glu Val His 
            100                 105                 110         


Gln Gln Glu Gln Glu Lys Leu Gln Gly Gln Ile Arg Glu Ser Lys Arg 
        115                 120                 125             


Asn Ser Arg Leu Gly Phe Leu Tyr Asp Leu Asp Lys Gln Val Lys Ser 
    130                 135                 140                 


Ile Glu Arg Phe Leu Arg Arg Leu Glu Phe His Ala Ser Lys Ile Asp 
145                 150                 155                 160 


Glu Leu Tyr Glu Ala Tyr Cys Val Gln Arg Arg Leu Arg Asp Gly Ala 
                165                 170                 175     


Tyr Asn Met Val Arg Ala Tyr Thr Thr Gly Ser Pro Gly Ser Arg Glu 
            180                 185                 190         


Ala Arg Asp Ser Leu Ala Glu Ala Thr Arg Gly His Arg Glu Tyr Thr 
        195                 200                 205             


Glu Ser Met Cys Leu Leu Glu Ser Glu Leu Glu Ala Gln Leu Gly Glu 
    210                 215                 220                 


Phe His Leu Arg Met Lys Gly Leu Ala Gly Phe Ala Arg Leu Cys Val 
225                 230                 235                 240 


Gly Asp Gln Tyr Glu Ile Cys Met Lys Tyr Gly Arg Gln Arg Trp Lys 
                245                 250                 255     


Leu Arg Gly Arg Ile Glu Gly Ser Gly Lys Gln Val Trp Asp Ser Glu 
            260                 265                 270         


Glu Thr Ile Phe Leu Pro Leu Leu Thr Glu Phe Leu Ser Ile Lys Val 
        275                 280                 285             


Thr Glu Leu Lys Gly Leu Ala Asn His Val Val Val Gly Ser Val Ser 
    290                 295                 300                 


Cys Glu Thr Lys Asp Leu Phe Ala Ala Leu Pro Gln Val Val Ala Val 
305                 310                 315                 320 


Asp Ile Asn Asp Leu Gly Thr Ile Lys Leu Ser Leu Glu Val Thr Trp 
                325                 330                 335     


Ser Pro Phe Asp Lys Asp Asp Gln Pro Ser Ala Ala Ser Ser Val Asn 
            340                 345                 350         


Lys Ala Ser Thr Val Thr Lys Arg Phe Ser Thr Tyr Ser Gln Ser Pro 
        355                 360                 365             


Pro Asp Thr Pro Ser Leu Arg Glu Gln Ala Phe Tyr Asn Met Leu Arg 
    370                 375                 380                 


Arg Gln Glu Glu Leu Glu Asn Gly Thr Ala Trp Ser Leu Ser Ser Glu 
385                 390                 395                 400 


Ser Ser Asp Asp Ser Ser Ser Pro Gln Leu Ser Gly Thr Ala Arg His 
                405                 410                 415     


Ser Pro Ala Pro Arg Pro Leu Val Gln Gln Pro Glu Pro Leu Pro Ile 
            420                 425                 430         


Gln Val Ala Phe Arg Arg Pro Glu Thr Pro Ser Ser Gly Pro Leu Asp 
        435                 440                 445             


Glu Glu Gly Ala Val Ala Pro Val Leu Ala Asn Gly His Ala Pro Tyr 
    450                 455                 460                 


Ser Arg Thr Leu Ser His Ile Ser Glu Ala Ser Val Asp Ala Ala Leu 
465                 470                 475                 480 


Ala Glu Ala Ser Val Glu Ala Val Gly Pro Glu Ser Leu Ala Trp Gly 
                485                 490                 495     


Pro Ser Pro Pro Thr His Pro Ala Pro Thr His Gly Glu His Pro Ser 
            500                 505                 510         


Pro Val Pro Pro Ala Leu Asp Pro Gly His Ser Ala Thr Ser Ser Thr 
        515                 520                 525             


Leu Gly Thr Thr Gly Ser Val Pro Thr Ser Thr Asp Pro Ala Pro Ser 
    530                 535                 540                 


Ala His Leu Asp Ser Val His Lys Ser Thr Asp Ser Gly Pro Ser Glu 
545                 550                 555                 560 


Leu Pro Gly Pro Thr His Thr Thr Thr Gly Ser Thr Tyr Ser Ala Ile 
                565                 570                 575     


Thr Thr Thr His Ser Ala Pro Ser Pro Leu Thr His Thr Thr Thr Gly 
            580                 585                 590         


Ser Thr His Lys Pro Ile Ile Ser Thr Leu Thr Thr Thr Gly Pro Thr 
        595                 600                 605             


Leu Asn Ile Ile Gly Pro Val Gln Thr Thr Thr Ser Pro Thr His Thr 
    610                 615                 620                 


Met Pro Ser Pro Thr His Thr Thr Ala Ser Pro Thr His Thr Ser Thr 
625                 630                 635                 640 


Ser Pro Thr His Thr Pro Thr Ser Pro Thr His Lys Thr Ser Met Ser 
                645                 650                 655     


Pro Pro Thr Thr Thr Ser Pro Thr Pro Ser Gly Met Gly Leu Val Gln 
            660                 665                 670         


Thr Ala Thr Ser Pro Thr His Pro Thr Thr Ser Pro Thr His Pro Thr 
        675                 680                 685             


Thr Ser Pro Ile Leu Ile Asn Val Ser Pro Ser Thr Ser Leu Glu Leu 
    690                 695                 700                 


Ala Thr Leu Ser Ser Pro Ser Lys His Ser Asp Pro Thr Leu Pro Gly 
705                 710                 715                 720 


Thr Asp Ser Leu Pro Cys Ser Pro Pro Val Ser Asn Ser Tyr Thr Gln 
                725                 730                 735     


Ala Asp Pro Met Ala Pro Arg Thr Pro His Pro Ser Pro Ala His Ser 
            740                 745                 750         


Ser Arg Lys Pro Leu Thr Ser Pro Ala Pro Asp Pro Ser Glu Ser Thr 
        755                 760                 765             


Val Gln Ser Leu Ser Pro Thr Pro Ser Pro Pro Thr Pro Ala Pro Gln 
    770                 775                 780                 


His Ser Asp Leu Cys Leu Ala Met Ala Val Gln Thr Pro Val Pro Thr 
785                 790                 795                 800 


Ala Ala Gly Gly Ser Gly Asp Arg Ser Leu Glu Glu Ala Leu Gly Ala 
                805                 810                 815     


Leu Met Ala Ala Leu Asp Asp Tyr Arg Gly Gln Phe Pro Glu Leu Gln 
            820                 825                 830         


Gly Leu Glu Gln Glu Val Thr Arg Leu Glu Ser Leu Leu Met Gln Arg 
        835                 840                 845             


Gln Gly Leu Thr Arg Ser Arg Ala Ser Ser Leu Ser Ile Thr Val Glu 
    850                 855                 860                 


His Ala Leu Glu Ser Phe Ser Phe Leu Asn Glu Asp Glu Asp Glu Asp 
865                 870                 875                 880 


Asn Asp Val Pro Gly Asp Arg Pro Pro Ser Ser Pro Glu Ala Gly Ala 
                885                 890                 895     


Glu Asp Ser Ile Asp Ser Pro Ser Ala Arg Pro Leu Ser Thr Gly Cys 
            900                 905                 910         


Pro Ala Leu Asp Ala Ala Leu Val Arg His Leu Tyr His Cys Ser Arg 
        915                 920                 925             


Leu Leu Leu Lys Leu Gly Thr Phe Gly Pro Leu Arg Cys Gln Glu Ala 
    930                 935                 940                 


Trp Ala Leu Glu Arg Leu Leu Arg Glu Ala Arg Val Leu Glu Ala Val 
945                 950                 955                 960 


Cys Glu Phe Ser Arg Arg Trp Glu Ile Pro Ala Ser Ser Ala Gln Glu 
                965                 970                 975     


Val Val Gln Phe Ser Ala Ser Arg Pro Gly Phe Leu Thr Phe Trp Asp 
            980                 985                 990         


Gln Cys Thr Glu Arg Leu Ser Cys  Phe Leu Cys Pro Val  Glu Arg Val 
        995                 1000                 1005             


Leu Leu  Thr Phe Cys Asn Gln  Tyr Gly Ala Arg Leu  Ser Leu Arg 
    1010                 1015                 1020             


Gln Pro  Gly Leu Ala Glu Ala  Val Cys Val Lys Phe  Leu Glu Asp 
    1025                 1030                 1035             


Ala Leu  Gly Gln Lys Leu Pro  Arg Arg Pro Gln Pro  Gly Pro Gly 
    1040                 1045                 1050             


Glu Gln  Leu Thr Val Phe Gln  Phe Trp Ser Phe Val  Glu Thr Leu 
    1055                 1060                 1065             


Asp Ser  Pro Thr Met Glu Ala  Tyr Val Thr Glu Thr  Ala Glu Glu 
    1070                 1075                 1080             


Val Leu  Leu Val Arg Asn Leu  Asn Ser Asp Asp Gln  Ala Val Val 
    1085                 1090                 1095             


Leu Lys  Ala Leu Arg Leu Ala  Pro Glu Gly Arg Leu  Arg Arg Asp 
    1100                 1105                 1110             


Gly Leu  Arg Ala Leu Ser Ser  Leu Leu Val His Gly  Asn Asn Lys 
    1115                 1120                 1125             


Val Met  Ala Ala Val Ser Thr  Gln Leu Arg Ser Leu  Ser Leu Gly 
    1130                 1135                 1140             


Pro Thr  Phe Arg Glu Arg Ala  Leu Leu Cys Phe Leu  Asp Gln Leu 
    1145                 1150                 1155             


Glu Asp  Glu Asp Val Gln Thr  Arg Val Ala Gly Cys  Leu Ala Leu 
    1160                 1165                 1170             


Gly Cys  Ile Lys Ala Pro Glu  Gly Ile Glu Pro Leu  Val Tyr Leu 
    1175                 1180                 1185             


Cys Gln  Thr Asp Thr Glu Ala  Val Arg Glu Ala Ala  Arg Gln Ser 
    1190                 1195                 1200             


Leu Gln  Gln Cys Gly Glu Glu  Gly Gln Ser Ala His  Arg Arg Leu 
    1205                 1210                 1215             


Glu Glu  Ser Leu Asp Ala Leu  Pro Arg Ile Phe Gly  Pro Gly Ser 
    1220                 1225                 1230             


Met Ala  Ser Thr Ala Phe 
    1235                 


<210> 7449
<211> 243
<212> PRT
<213> Homo sapiens

<400> 7449
Met Val Thr Asp Tyr Gly Ala Phe Ile Lys Ile Pro Gly Cys Arg Lys 
1               5                   10                  15      


Gln Gly Leu Val His Arg Thr His Met Ser Ser Cys Arg Val Asp Lys 
            20                  25                  30          


Pro Ser Glu Ile Val Asp Val Gly Asp Lys Val Trp Val Lys Leu Ile 
        35                  40                  45              


Gly Arg Glu Met Lys Asn Asp Arg Ile Lys Val Ser Leu Ser Met Lys 
    50                  55                  60                  


Val Val Asn Gln Gly Thr Gly Lys Asp Leu Asp Pro Asn Asn Val Ile 
65                  70                  75                  80  


Ile Glu Gln Glu Glu Arg Arg Arg Arg Ser Phe Gln Asp Tyr Thr Gly 
                85                  90                  95      


Gln Lys Ile Thr Leu Glu Ala Val Leu Asn Thr Thr Cys Lys Lys Cys 
            100                 105                 110         


Gly Cys Lys Gly Arg Val Lys Pro Leu Pro Phe Pro Arg Phe Ser Pro 
        115                 120                 125             


Cys Gly Trp Thr Leu Phe Trp Lys Lys Glu Ala Ala Gln Cys His Phe 
    130                 135                 140                 


Ala Lys Asp Cys Phe Met Gln Pro Gly Gly Thr Lys Tyr Ser Leu Ile 
145                 150                 155                 160 


Pro Asp Glu Glu Glu Glu Lys Glu Glu Ala Lys Ser Ala Glu Phe Glu 
                165                 170                 175     


Lys Pro Asp Pro Thr Arg Asn Pro Ser Arg Lys Arg Lys Lys Glu Lys 
            180                 185                 190         


Lys Lys Lys Lys His Arg Asp Arg Lys Ser Ser Asp Ser Asp Ser Ser 
        195                 200                 205             


Asp Ser Glu Ser Asp Thr Gly Lys Arg Ala Arg His Thr Ser Lys Asp 
    210                 215                 220                 


Ser Lys Ala Ala Lys Lys Lys Lys Lys Lys Lys Lys His Lys Lys Lys 
225                 230                 235                 240 


His Lys Glu 
            


<210> 7450
<211> 109
<212> PRT
<213> Homo sapiens

<400> 7450
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Phe Pro 
        35                  40                  45              


Ile Ser Lys Pro Asp Gly Ile Ser Gln Leu Glu Gln Asp Leu Gln Val 
    50                  55                  60                  


Phe Asp Leu Glu Thr Lys Thr Arg Glu Val Leu Arg Asp Asp Cys Ser 
65                  70                  75                  80  


Asp Gly Glu Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys 
                85                  90                  95      


Ile Ser Glu Glu Val His Ser Tyr Lys Val Arg Val Gly 
            100                 105                 


<210> 7451
<211> 1377
<212> PRT
<213> Homo sapiens

<400> 7451
Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Ala Ser Ala Arg Trp Arg Arg Cys Ser Ser 
625                 630                 635                 640 


Gly Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys Ala 
                645                 650                 655     


Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp Pro 
            660                 665                 670         


His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp Pro 
        675                 680                 685             


Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn Ser 
    690                 695                 700                 


Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro Gly 
705                 710                 715                 720 


Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly Pro 
                725                 730                 735     


Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro Ala 
            740                 745                 750         


Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg Val 
        755                 760                 765             


Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr Ala 
    770                 775                 780                 


Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly Ser 
785                 790                 795                 800 


Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys Ala 
                805                 810                 815     


Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala Gly 
            820                 825                 830         


Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro Arg 
        835                 840                 845             


Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly Ser 
    850                 855                 860                 


Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg Leu 
865                 870                 875                 880 


Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser Ser 
                885                 890                 895     


Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser Glu 
            900                 905                 910         


Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala Pro 
        915                 920                 925             


Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe Leu 
    930                 935                 940                 


Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu Ala 
945                 950                 955                 960 


Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro Arg 
                965                 970                 975     


Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu Ile 
            980                 985                 990         


Pro Asp Val Leu Gln Ser Asn Asp  Glu Val Leu Ala Glu  Val Thr Ser 
        995                 1000                 1005             


Trp Asp  Leu Pro Pro Leu Thr  Asp Arg Tyr Arg Arg  Ala Cys Gln 
    1010                 1015                 1020             


Ser Leu  Gly Gln Gly Glu His  Gln Gln Val Leu Gln  Ala Val Glu 
    1025                 1030                 1035             


Leu Gln  Gly Leu Gly Leu Ser  Phe Ser Ala Cys Ser  Leu Ala Leu 
    1040                 1045                 1050             


Asp Gln  Ala Gln Leu Thr Pro  Leu Leu Arg Ala Leu  Lys Leu His 
    1055                 1060                 1065             


Thr Ala  Leu Arg Glu Leu Arg  Leu Ala Gly Asn Arg  Leu Gly Asp 
    1070                 1075                 1080             


Lys Cys  Val Ala Glu Leu Val  Ala Ala Leu Gly Thr  Met Pro Ser 
    1085                 1090                 1095             


Leu Ala  Leu Leu Asp Leu Ser  Ser Asn His Leu Gly  Pro Glu Gly 
    1100                 1105                 1110             


Leu Arg  Gln Leu Ala Met Gly  Leu Pro Gly Gln Ala  Thr Leu Gln 
    1115                 1120                 1125             


Ser Leu  Glu Glu Leu Asp Leu  Ser Met Asn Pro Leu  Gly Asp Gly 
    1130                 1135                 1140             


Cys Gly  Gln Ser Leu Ala Ser  Leu Leu His Ala Cys  Pro Leu Leu 
    1145                 1150                 1155             


Ser Thr  Leu Arg Leu Gln Ala  Cys Gly Phe Gly Pro  Ser Phe Phe 
    1160                 1165                 1170             


Leu Ser  His Gln Thr Ala Leu  Gly Ser Ala Phe Gln  Asp Ala Glu 
    1175                 1180                 1185             


His Leu  Lys Thr Leu Ser Leu  Ser Tyr Asn Ala Leu  Gly Ala Pro 
    1190                 1195                 1200             


Ala Leu  Ala Arg Thr Leu Gln  Ser Leu Pro Ala Gly  Thr Leu Leu 
    1205                 1210                 1215             


His Leu  Glu Leu Ser Ser Val  Ala Ala Gly Lys Gly  Asp Ser Asp 
    1220                 1225                 1230             


Leu Met  Glu Pro Val Phe Arg  Tyr Leu Ala Lys Glu  Gly Cys Ala 
    1235                 1240                 1245             


Leu Ala  His Leu Thr Leu Ser  Ala Asn His Leu Gly  Asp Lys Ala 
    1250                 1255                 1260             


Val Arg  Asp Leu Cys Arg Cys  Leu Ser Leu Cys Pro  Ser Leu Ile 
    1265                 1270                 1275             


Ser Leu  Asp Leu Ser Ala Asn  Pro Glu Ile Ser Cys  Ala Ser Leu 
    1280                 1285                 1290             


Glu Glu  Leu Leu Ser Thr Leu  Gln Lys Arg Pro Gln  Gly Leu Ser 
    1295                 1300                 1305             


Phe Leu  Gly Leu Ser Gly Cys  Ala Val Gln Gly Pro  Leu Gly Leu 
    1310                 1315                 1320             


Gly Leu  Trp Asp Lys Ile Ala  Ala Gln Leu Arg Glu  Leu Gln Leu 
    1325                 1330                 1335             


Cys Ser  Arg Arg Leu Cys Ala  Glu Asp Arg Asp Ala  Leu Arg Gln 
    1340                 1345                 1350             


Leu Gln  Pro Ser Arg Pro Gly  Pro Gly Glu Cys Thr  Leu Asp His 
    1355                 1360                 1365             


Gly Ser  Lys Leu Phe Phe Arg  Arg Leu 
    1370                 1375         


<210> 7452
<211> 224
<212> PRT
<213> Homo sapiens

<400> 7452
Met Pro Thr Leu Phe Lys Gly Val Trp Gly Val Val Glu His Ser Arg 
1               5                   10                  15      


Ala Leu Gly Arg Phe Cys Pro Ala Cys Leu Pro Ser Gly Pro His Leu 
            20                  25                  30          


His Thr Gln Pro Ala Leu Gly Thr Ala Glu Met Thr Leu Leu Ser Ser 
        35                  40                  45              


Gln Ser Ser Ser Leu Val Ala Pro Ser Gly Ser Val Ser Ala Glu Asn 
    50                  55                  60                  


Pro Glu Gln Arg Met Leu Glu Lys Arg Ala Lys Val Ile Glu Glu Leu 
65                  70                  75                  80  


Leu Gln Thr Glu Arg Asp Tyr Ile Arg Asp Leu Glu Met Cys Ile Glu 
                85                  90                  95      


Arg Ile Met Val Pro Met Gln Gln Ala Gln Val Pro Asn Ile Asp Phe 
            100                 105                 110         


Glu Gly Leu Phe Gly Asn Met Gln Met Val Ile Lys Val Ser Lys Gln 
        115                 120                 125             


Leu Leu Ala Ala Leu Glu Ile Ser Asp Ala Val Gly Pro Val Phe Leu 
    130                 135                 140                 


Gly His Arg Asp Glu Leu Glu Gly Thr Tyr Lys Ile Tyr Cys Gln Asn 
145                 150                 155                 160 


His Asp Glu Ala Ile Ala Leu Leu Glu Ile Tyr Glu Lys Asp Glu Lys 
                165                 170                 175     


Ile Gln Lys His Leu Gln Asp Ser Leu Ala Asp Leu Lys Ser Leu Tyr 
            180                 185                 190         


Asn Glu Trp Gly Cys Thr Asn Tyr Ile Asn Leu Gly Ser Phe Leu Ile 
        195                 200                 205             


Lys Pro Val Gln Arg Val Met Arg Tyr Pro Leu Leu Leu Met Glu Leu 
    210                 215                 220                 


<210> 7453
<211> 117
<212> PRT
<213> Homo sapiens

<400> 7453
Val Cys Gly Asp Tyr Leu Leu Ser Arg Met Asp Val Thr Ser Cys Ile 
1               5                   10                  15      


Ser Tyr Arg Asn Phe Ala Ser Cys Met Gly Asp Ser Arg Leu Leu Asn 
            20                  25                  30          


Lys Val Asp Ala Tyr Ile Gln Glu His Leu Leu Gln Ile Ser Glu Glu 
        35                  40                  45              


Glu Glu Phe Leu Lys Leu Pro Arg Leu Lys Leu Glu Val Met Leu Glu 
    50                  55                  60                  


Asp Asn Val Cys Leu Pro Ser Asn Gly Lys Leu Tyr Thr Lys Val Ile 
65                  70                  75                  80  


Asn Trp Val Gln Arg Ser Ile Trp Glu Asn Gly Asp Ser Leu Glu Glu 
                85                  90                  95      


Leu Met Glu Glu Val Ser Phe Lys Val Asn Gly Ile Gln Pro Phe Leu 
            100                 105                 110         


Lys Ile Ile Leu Leu 
        115         


<210> 7454
<211> 94
<212> PRT
<213> Homo sapiens

<400> 7454
Met Leu Cys Trp Gly Tyr Trp Ser Leu Gly Gln Pro Gly Ile Ser Thr 
1               5                   10                  15      


Asn Leu Gln Gly Ile Val Ala Glu Pro Gln Val Cys Gly Phe Ile Ser 
            20                  25                  30          


Asp Arg Ser Val Lys Glu Val Ala Cys Gly Gly Asn His Ser Val Phe 
        35                  40                  45              


Leu Leu Glu Asp Gly Glu Val Tyr Thr Cys Gly Leu Asn Thr Lys Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Arg Glu Gly Asn Lys Pro Glu Gln Ile Gly Ala 
65                  70                  75                  80  


Leu Ala Asp Gln His Ile Ile His Val Ala Cys Gly Glu Ser 
                85                  90                  


<210> 7455
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7455
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 7456
<211> 937
<212> PRT
<213> Homo sapiens

<400> 7456
Met Glu Pro Asp Ile Ile Arg Met Tyr Ser Ser Ser Pro Pro Pro Leu 
1               5                   10                  15      


Asp Asn Gly Ala Glu Asp Asp Asp Asp Asp Glu Phe Gly Glu Phe Gly 
            20                  25                  30          


Gly Phe Ser Glu Val Ser Pro Ser Gly Val Gly Phe Val Asp Phe Asp 
        35                  40                  45              


Thr Pro Asp Tyr Thr Arg Pro Lys Glu Glu Phe Val Pro Ser Asn His 
    50                  55                  60                  


Phe Met Pro Ile His Glu Phe Ser Glu Asn Val Asp Ser Leu Thr Ser 
65                  70                  75                  80  


Phe Lys Ser Ile Lys Asn Gly Asn Asp Lys Asp Ile Thr Ala Glu Leu 
                85                  90                  95      


Ser Ala Pro Val Lys Gly Gln Ser Asp Val Leu Leu Ser Thr Thr Ser 
            100                 105                 110         


Lys Glu Ile Ile Ser Ser Glu Met Leu Ala Thr Ser Ile Asp Gly Met 
        115                 120                 125             


Glu Arg Pro Gly Asn Leu Asn Lys Val Val Glu Gln Arg Gln Asn Val 
    130                 135                 140                 


Gly Thr Leu Glu Ser Phe Ser Pro Gly Asp Phe Arg Thr Asn Met Asn 
145                 150                 155                 160 


Val Val His Gln Asn Lys Gln Leu Glu Ser Cys Asn Gly Glu Lys Pro 
                165                 170                 175     


Pro Cys Leu Glu Ile Leu Thr Asn Gly Phe Ala Val Leu Glu Thr Val 
            180                 185                 190         


Asn Pro Gln Gly Thr Asp Asp Leu Asp Asn Val Ala Asp Ser Lys Gly 
        195                 200                 205             


Arg Lys Pro Leu Ser Thr His Ser Thr Glu Tyr Asn Leu Asp Ser Val 
    210                 215                 220                 


Pro Ser Pro Ala Glu Glu Phe Ala Asp Phe Ala Thr Phe Ser Lys Lys 
225                 230                 235                 240 


Glu Arg Ile Gln Leu Glu Glu Ile Glu Cys Ala Val Leu Asn Asp Arg 
                245                 250                 255     


Glu Ala Leu Thr Ile Arg Glu Asn Asn Lys Ile Asn Arg Val Asn Glu 
            260                 265                 270         


Leu Asn Ser Val Lys Glu Val Ala Leu Gly Arg Ser Leu Asp Asn Lys 
        275                 280                 285             


Gly Asp Thr Asp Gly Glu Asp Gln Val Cys Val Ser Glu Ile Ser Ile 
    290                 295                 300                 


Val Thr Asn Arg Gly Phe Ser Val Glu Lys Gln Gly Leu Pro Thr Leu 
305                 310                 315                 320 


Gln Gln Asp Glu Phe Leu Gln Ser Gly Val Gln Ser Lys Ala Trp Ser 
                325                 330                 335     


Leu Val Asp Ser Ala Asp Asn Ser Glu Ala Ile Arg Arg Glu Gln Cys 
            340                 345                 350         


Lys Thr Glu Glu Lys Leu Asp Leu Leu Thr Ser Lys Cys Ala His Leu 
        355                 360                 365             


Cys Met Asp Ser Val Lys Thr Ser Asp Asp Glu Val Gly Ser Pro Lys 
    370                 375                 380                 


Glu Glu Ser Arg Lys Phe Thr Asn Phe Gln Ser Pro Asn Ile Asp Pro 
385                 390                 395                 400 


Thr Glu Glu Asn Asp Leu Asp Asp Ser Leu Ser Val Lys Asn Gly Asp 
                405                 410                 415     


Ser Ser Asn Asp Phe Val Thr Cys Asn Asp Ile Asn Glu Asp Asp Phe 
            420                 425                 430         


Gly Asp Phe Gly Asp Phe Gly Ser Ala Ser Gly Ser Thr Pro Pro Phe 
        435                 440                 445             


Val Thr Gly Thr Gln Asp Ser Met Ser Asp Ala Thr Phe Glu Glu Ser 
    450                 455                 460                 


Ser Glu His Phe Pro His Phe Ser Glu Pro Gly Asp Asp Phe Gly Glu 
465                 470                 475                 480 


Phe Gly Asp Ile Asn Ala Val Ser Cys Gln Glu Glu Thr Ile Leu Thr 
                485                 490                 495     


Lys Ser Asp Leu Lys Gln Thr Ser Asp Asn Leu Ser Glu Glu Cys Gln 
            500                 505                 510         


Leu Ala Arg Lys Ser Ser Gly Thr Gly Thr Glu Pro Val Ala Lys Leu 
        515                 520                 525             


Lys Asn Gly Gln Glu Gly Glu Ile Gly His Phe Asp Ser Val Pro Asn 
    530                 535                 540                 


Ile Gln Asp Asp Cys Asn Gly Phe Gln Asp Ser Asp Asp Phe Ala Asp 
545                 550                 555                 560 


Phe Ser Ser Ala Gly Pro Ser Gln Val Val Asp Trp Asn Ala Phe Glu 
                565                 570                 575     


Asp Glu Gln Lys Asp Ser Cys Ser Trp Ala Ala Phe Gly Asp Gln Gln 
            580                 585                 590         


Ala Thr Glu Ser His His Arg Lys Glu Ala Trp Gln Ser His Arg Thr 
        595                 600                 605             


Asp Glu Asn Ile Asp Thr Pro Gly Thr Pro Lys Thr His Ser Val Pro 
    610                 615                 620                 


Ser Ala Thr Ser Lys Gly Ala Val Ala Ser Gly His Leu Gln Glu Ser 
625                 630                 635                 640 


Ala Thr Ser Val Gln Thr Ala Leu Leu Asn Arg Leu Glu Arg Ile Phe 
                645                 650                 655     


Glu Ala Cys Phe Pro Ser Ile Leu Val Pro Asp Ala Glu Glu Glu Val 
            660                 665                 670         


Thr Ser Leu Lys His Leu Leu Glu Thr Ser Thr Leu Pro Ile Lys Thr 
        675                 680                 685             


Arg Glu Ala Leu Pro Glu Ser Gly Glu Leu Leu Asp Val Trp Thr Glu 
    690                 695                 700                 


Leu Gln Asp Ile His Asp Ala His Gly Leu Arg Tyr Gln Trp Gly Gly 
705                 710                 715                 720 


Ser His Ser Asn Lys Lys Leu Leu Ser Ser Leu Gly Ile Asp Thr Arg 
                725                 730                 735     


Asn Ile Leu Phe Thr Gly Asn Lys Lys Gln Pro Val Ile Val Pro Met 
            740                 745                 750         


Tyr Ala Ala Gly Leu Gly Met Leu Glu Pro Thr Lys Glu Pro Leu Lys 
        755                 760                 765             


Pro Leu Ser Ala Ala Glu Lys Ile Ala Ser Ile Gly Gln Thr Ala Thr 
    770                 775                 780                 


Met Ser Pro Asp Met Asn Thr Cys Thr Ser Asp Gln Phe Gln Glu Ser 
785                 790                 795                 800 


Leu Pro Pro Val Gln Phe Asp Trp Ser Ser Ser Gly Leu Thr Asn Pro 
                805                 810                 815     


Leu Asp Ala Ser Gly Gly Ser Thr Leu Leu Asn Leu Asp Phe Phe Gly 
            820                 825                 830         


Pro Val Asp Asp Ser Ser Ser Ser Ser Ser Thr Thr Ile Pro Gly Val 
        835                 840                 845             


Asp Pro Glu Leu Tyr Glu Leu Thr Thr Ser Lys Leu Glu Ile Ser Thr 
    850                 855                 860                 


Ser Ser Leu Lys Val Thr Asp Ala Phe Ala Arg Leu Met Ser Thr Val 
865                 870                 875                 880 


Glu Lys Thr Ser Thr Ser Thr Ser Arg Lys Pro Lys Arg Glu Glu His 
                885                 890                 895     


Leu Ser Glu Glu Ala Ile Lys Val Ile Ala Gly Leu Pro Asp Leu Thr 
            900                 905                 910         


Phe Met His Ala Lys Val Leu Met Phe Pro Ala Thr Leu Thr Pro Ser 
        915                 920                 925             


Thr Ser Ser Gln Glu Lys Ala Asp Gly 
    930                 935         


<210> 7457
<211> 37
<212> PRT
<213> Homo sapiens

<400> 7457
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp 
        35          


<210> 7458
<211> 102
<212> PRT
<213> Homo sapiens

<400> 7458
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser 
            100         


<210> 7459
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7459
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 7460
<211> 115
<212> PRT
<213> Homo sapiens

<400> 7460
Met Ala Gly Ala Pro Thr Val Ser Leu Pro Glu Leu Arg Ser Leu Leu 
1               5                   10                  15      


Ala Ser Gly Arg Ala Arg Leu Phe Asp Val Arg Ser Arg Glu Glu Ala 
            20                  25                  30          


Ala Ala Gly Thr Ile Pro Gly Ala Leu Asn Ile Pro Val Ser Glu Leu 
        35                  40                  45              


Glu Ser Ala Leu Gln Met Glu Pro Ala Ala Phe Gln Ala Leu Tyr Ser 
    50                  55                  60                  


Ala Glu Lys Pro Lys Leu Glu Asp Glu His Leu Val Phe Phe Cys Gln 
65                  70                  75                  80  


Met Gly Lys Arg Gly Leu Gln Ala Thr Gln Leu Ala Arg Ser Leu Gly 
                85                  90                  95      


Tyr Thr Gly Ala Arg Asn Tyr Ala Gly Ala Tyr Arg Glu Trp Leu Glu 
            100                 105                 110         


Lys Glu Ser 
        115 


<210> 7461
<211> 1588
<212> PRT
<213> Homo sapiens

<400> 7461
Met Leu Pro Pro Lys His Leu Ser Ala Thr Lys Pro Lys Lys Ser Trp 
1               5                   10                  15      


Ala Pro Asn Leu Tyr Glu Leu Asp Ser Asp Leu Thr Lys Glu Pro Asp 
            20                  25                  30          


Val Ile Ile Gly Glu Gly Pro Thr Asp Ser Glu Phe Phe His Gln Arg 
        35                  40                  45              


Phe Arg Asn Leu Ile Tyr Val Glu Phe Val Gly Pro Arg Lys Thr Leu 
    50                  55                  60                  


Ile Lys Leu Arg Asn Leu Cys Leu Asp Trp Leu Gln Pro Glu Thr Arg 
65                  70                  75                  80  


Thr Lys Glu Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr 
                85                  90                  95      


Ile Ile Pro Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu 
            100                 105                 110         


Asn Cys Glu Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr 
        115                 120                 125             


Gln Pro Glu Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met 
    130                 135                 140                 


Thr Arg Asn Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe 
145                 150                 155                 160 


Ser Asp Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu Pro 
                165                 170                 175     


Arg Asp Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro Pro 
            180                 185                 190         


Arg Asp Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met Asp 
        195                 200                 205             


Arg Glu Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln Asp 
    210                 215                 220                 


Ala Glu Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys Pro 
225                 230                 235                 240 


His Asn Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu Ser 
                245                 250                 255     


Leu Val Gln Leu Ala Glu Asp Asp Gly His Ser His Met Thr Gln Gly 
            260                 265                 270         


His Ser Ser Arg Ser Lys Arg Ser Ala Tyr Pro Ser Thr Ser Arg Gly 
        275                 280                 285             


Leu Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His Arg Arg Gly Ile 
    290                 295                 300                 


Cys Glu Asp Glu Ser Ser His Gly Val Ile Met Glu Lys Phe Ile Lys 
305                 310                 315                 320 


Asp Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg Glu Ser Ser Asp 
                325                 330                 335     


Arg Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn Trp Lys Asp Ile 
            340                 345                 350         


Ser Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg Val Tyr Glu Gly 
        355                 360                 365             


Asn Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr Leu Val Ser Arg 
    370                 375                 380                 


Lys Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe Asp Thr Asp Gly 
385                 390                 395                 400 


Lys Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg Lys Lys Pro Phe 
                405                 410                 415     


Glu Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val Ser Ser Leu Ser 
            420                 425                 430         


Ser Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro Ile Asp Phe Gly 
        435                 440                 445             


Ala Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser Phe Ser Val Ile 
    450                 455                 460                 


Ser Glu Phe Val Glu His Gln Ile Met His Thr Arg Glu Asn Leu Tyr 
465                 470                 475                 480 


Glu Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val Ser Glu Val Gln 
                485                 490                 495     


Lys Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys Asp Cys Gly Glu 
            500                 505                 510         


Thr Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg Lys Ile His Ala 
        515                 520                 525             


Arg Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys Glu Glu Ala Phe 
    530                 535                 540                 


Met Pro Ser Pro Thr Phe Ser Glu Leu Gln Lys Ile Tyr Gly Lys Asp 
545                 550                 555                 560 


Lys Phe Tyr Glu Cys Arg Val Cys Lys Glu Thr Phe Leu His Ser Ser 
                565                 570                 575     


Ala Leu Ile Glu His Gln Lys Ile His Phe Gly Asp Asp Lys Asp Asn 
            580                 585                 590         


Glu Arg Glu His Glu Arg Glu Arg Glu Arg Glu Arg Gly Glu Thr Phe 
        595                 600                 605             


Arg Pro Ser Pro Ala Leu Asn Glu Phe Gln Lys Met Tyr Gly Lys Glu 
    610                 615                 620                 


Lys Met Tyr Glu Cys Lys Val Cys Gly Glu Thr Phe Leu His Ser Ser 
625                 630                 635                 640 


Ser Leu Lys Glu His Gln Lys Ile His Thr Arg Gly Asn Pro Phe Glu 
                645                 650                 655     


Asn Lys Gly Lys Val Cys Glu Glu Thr Phe Ile Pro Gly Gln Ser Leu 
            660                 665                 670         


Lys Arg Arg Gln Lys Thr Tyr Asn Lys Glu Lys Leu Cys Asp Phe Thr 
        675                 680                 685             


Asp Gly Arg Asp Ala Phe Met Gln Ser Ser Glu Leu Ser Glu His Gln 
    690                 695                 700                 


Lys Ile His Ser Arg Lys Asn Leu Phe Glu Gly Arg Gly Tyr Glu Lys 
705                 710                 715                 720 


Ser Val Ile His Ser Gly Pro Phe Thr Glu Ser Gln Lys Ser His Thr 
                725                 730                 735     


Ile Thr Arg Pro Leu Glu Ser Asp Glu Asp Glu Lys Ala Phe Thr Ile 
            740                 745                 750         


Ser Ser Asn Pro Tyr Glu Asn Gln Lys Ile Pro Thr Lys Glu Asn Val 
        755                 760                 765             


Tyr Glu Ala Lys Ser Tyr Glu Arg Ser Val Ile His Ser Leu Ala Ser 
    770                 775                 780                 


Val Glu Ala Gln Lys Ser His Ser Val Ala Gly Pro Ser Lys Pro Lys 
785                 790                 795                 800 


Val Met Ala Glu Ser Thr Ile Gln Ser Phe Asp Ala Ile Asn His Gln 
                805                 810                 815     


Arg Val Arg Ala Gly Gly Asn Thr Ser Glu Gly Arg Glu Tyr Ser Arg 
            820                 825                 830         


Ser Val Ile His Ser Leu Val Ala Ser Lys Pro Pro Arg Ser His Asn 
        835                 840                 845             


Gly Asn Glu Leu Val Glu Ser Asn Glu Lys Gly Glu Ser Ser Ile Tyr 
    850                 855                 860                 


Ile Ser Asp Leu Asn Asp Lys Arg Gln Lys Ile Pro Ala Arg Glu Asn 
865                 870                 875                 880 


Pro Cys Glu Gly Gly Ser Lys Asn Arg Asn Tyr Glu Asp Ser Val Ile 
                885                 890                 895     


Gln Ser Val Phe Arg Ala Lys Pro Gln Lys Ser Val Pro Gly Glu Gly 
            900                 905                 910         


Ser Gly Glu Phe Lys Lys Asp Gly Glu Phe Ser Val Pro Ser Ser Asn 
        915                 920                 925             


Val Arg Glu Tyr Gln Lys Ala Arg Ala Lys Lys Lys Tyr Ile Glu His 
    930                 935                 940                 


Arg Ser Asn Glu Thr Ser Val Ile His Ser Leu Pro Phe Gly Glu Gln 
945                 950                 955                 960 


Thr Phe Arg Pro Arg Gly Met Leu Tyr Glu Cys Gln Glu Cys Gly Glu 
                965                 970                 975     


Cys Phe Ala His Ser Ser Asp Leu Thr Glu His Gln Lys Ile His Asp 
            980                 985                 990         


Arg Glu Lys Pro Ser Gly Ser Arg  Asn Tyr Glu Trp Ser  Val Ile Arg 
        995                 1000                 1005             


Ser Leu  Ala Pro Thr Asp Pro  Gln Thr Ser Tyr Ala  Gln Glu Gln 
    1010                 1015                 1020             


Tyr Ala  Lys Glu Gln Ala Arg  Asn Lys Cys Lys Asp  Phe Arg Gln 
    1025                 1030                 1035             


Phe Phe  Ala Thr Ser Glu Asp  Leu Asn Thr Asn Gln  Lys Ile Tyr 
    1040                 1045                 1050             


Asp Gln  Glu Lys Ser His Gly  Glu Glu Ser Gln Gly  Glu Asn Thr 
    1055                 1060                 1065             


Asp Gly  Glu Glu Thr His Ser  Glu Glu Thr His Gly  Gln Glu Thr 
    1070                 1075                 1080             


Ile Glu  Asp Pro Val Ile Gln  Gly Ser Asp Met Glu  Asp Pro Gln 
    1085                 1090                 1095             


Lys Asp  Asp Pro Asp Asp Lys  Ile Tyr Glu Cys Glu  Asp Cys Gly 
    1100                 1105                 1110             


Leu Gly  Phe Val Asp Leu Thr  Asp Leu Thr Asp His  Gln Lys Val 
    1115                 1120                 1125             


His Ser  Arg Lys Cys Leu Val  Asp Ser Arg Glu Tyr  Thr His Ser 
    1130                 1135                 1140             


Val Ile  His Thr His Ser Ile  Ser Glu Tyr Gln Arg  Asp Tyr Thr 
    1145                 1150                 1155             


Gly Glu  Gln Leu Tyr Glu Cys  Pro Lys Cys Gly Glu  Ser Phe Ile 
    1160                 1165                 1170             


His Ser  Ser Phe Leu Phe Glu  His Gln Arg Ile His  Glu Gln Asp 
    1175                 1180                 1185             


Gln Leu  Tyr Ser Met Lys Gly  Cys Asp Asp Gly Phe  Ile Ala Leu 
    1190                 1195                 1200             


Leu Pro  Met Lys Pro Arg Arg  Asn Arg Ala Ala Glu  Arg Asn Pro 
    1205                 1210                 1215             


Ala Leu  Ala Gly Ser Ala Ile  Arg Cys Leu Leu Cys  Gly Gln Gly 
    1220                 1225                 1230             


Phe Ile  His Ser Ser Ala Leu  Asn Glu His Met Arg  Leu His Arg 
    1235                 1240                 1245             


Glu Asp  Asp Leu Leu Glu Gln  Ser Gln Met Ala Glu  Glu Ala Ile 
    1250                 1255                 1260             


Ile Pro  Gly Leu Ala Leu Thr  Glu Phe Gln Arg Ser  Gln Thr Glu 
    1265                 1270                 1275             


Glu Arg  Leu Phe Glu Cys Ala  Val Cys Gly Glu Ser  Phe Val Asn 
    1280                 1285                 1290             


Pro Ala  Glu Leu Ala Asp His  Val Thr Val His Lys  Asn Glu Pro 
    1295                 1300                 1305             


Tyr Glu  Tyr Gly Ser Ser Tyr  Thr His Thr Ser Phe  Leu Thr Glu 
    1310                 1315                 1320             


Pro Leu  Lys Gly Ala Ile Pro  Phe Tyr Glu Cys Lys  Asp Cys Gly 
    1325                 1330                 1335             


Lys Ser  Phe Ile His Ser Thr  Val Leu Thr Lys His  Lys Glu Leu 
    1340                 1345                 1350             


His Leu  Glu Glu Glu Glu Glu  Asp Glu Ala Ala Ala  Ala Ala Ala 
    1355                 1360                 1365             


Ala Ala  Ala Gln Glu Val Glu  Ala Asn Val His Val  Pro Gln Val 
    1370                 1375                 1380             


Val Leu  Arg Ile Gln Gly Leu  Asn Val Glu Ala Ala  Glu Pro Glu 
    1385                 1390                 1395             


Val Glu  Ala Ala Glu Pro Glu  Val Glu Ala Ala Glu  Pro Glu Val 
    1400                 1405                 1410             


Glu Ala  Ala Glu Pro Asn Gly  Glu Ala Glu Gly Pro  Asp Gly Glu 
    1415                 1420                 1425             


Ala Ala  Glu Pro Ile Gly Glu  Ala Gly Gln Pro Asn  Gly Glu Ala 
    1430                 1435                 1440             


Glu Gln  Pro Asn Gly Asp Ala  Asp Glu Pro Asp Gly  Ala Gly Ile 
    1445                 1450                 1455             


Glu Asp  Pro Glu Glu Arg Ala  Glu Glu Pro Glu Gly  Lys Ala Glu 
    1460                 1465                 1470             


Glu Pro  Glu Gly Asp Ala Asp  Glu Pro Asp Gly Val  Gly Ile Glu 
    1475                 1480                 1485             


Asp Pro  Glu Glu Gly Glu Asp  Gln Glu Ile Gln Val  Glu Glu Pro 
    1490                 1495                 1500             


Tyr Tyr  Asp Cys His Glu Cys  Thr Glu Thr Phe Thr  Ser Ser Thr 
    1505                 1510                 1515             


Ala Phe  Ser Glu His Leu Lys  Thr His Ala Ser Met  Ile Ile Phe 
    1520                 1525                 1530             


Glu Pro  Ala Asn Ala Phe Gly  Glu Cys Ser Gly Tyr  Ile Glu Arg 
    1535                 1540                 1545             


Ala Ser  Thr Ser Thr Gly Gly  Ala Asn Gln Ala Asp  Glu Lys Tyr 
    1550                 1555                 1560             


Phe Lys  Cys Asp Val Cys Gly  Gln Leu Phe Asn Asp  Arg Leu Ser 
    1565                 1570                 1575             


Leu Ala  Arg His Gln Asn Thr  His Thr Gly 
    1580                 1585             


<210> 7462
<211> 126
<212> PRT
<213> Homo sapiens

<400> 7462
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe 
                85                  90                  95      


Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile 
            100                 105                 110         


Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val 
        115                 120                 125     


<210> 7463
<211> 477
<212> PRT
<213> Homo sapiens

<400> 7463
Met Ala Asp Gly Gln Val Ala Glu Leu Leu Leu Arg Arg Leu Glu Ala 
1               5                   10                  15      


Ser Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Ala Glu Leu Gly Met 
            20                  25                  30          


Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly 
        35                  40                  45              


Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys His Trp Glu Leu Thr 
    50                  55                  60                  


Ala Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val 
65                  70                  75                  80  


Phe Arg Ser Ile Pro Pro Glu Gly Leu Ala Gln Ser Glu Leu Met Arg 
                85                  90                  95      


Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp 
            100                 105                 110         


Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val 
        115                 120                 125             


Val Asp Ser Met Glu Asp Glu Val Gln Arg Arg Leu Gln Leu Val Arg 
    130                 135                 140                 


Gly Gly Gln Ala Glu Lys Leu Gly Glu Lys Glu Arg Ser Glu Leu Arg 
145                 150                 155                 160 


Lys Arg Lys Leu Leu Ala Glu Val Gly Ser Trp Arg Asp Arg Pro Phe 
                165                 170                 175     


Lys Pro Tyr Asn Phe Leu Ala His Gly Val Leu Pro Asp Ser Gly His 
            180                 185                 190         


Leu His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu 
        195                 200                 205             


Glu Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser 
    210                 215                 220                 


Phe Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg 
225                 230                 235                 240 


Asp Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln 
                245                 250                 255     


Leu Pro Met Asp Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly 
            260                 265                 270         


Gly Tyr Gly Ser Gln Gly Tyr Lys Tyr Asn Trp Lys Leu Asp Glu Ala 
        275                 280                 285             


Arg Lys Asn Leu Leu Arg Thr His Thr Thr Ser Ala Ser Ala Arg Ala 
    290                 295                 300                 


Leu Tyr Arg Leu Ala Gln Lys Lys Pro Phe Thr Pro Val Lys Tyr Phe 
305                 310                 315                 320 


Ser Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu 
                325                 330                 335     


Ala Glu Phe His Gln Ile Glu Gly Val Val Ala Asp His Gly Leu Thr 
            340                 345                 350         


Leu Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly 
        355                 360                 365             


Ile Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Thr Glu Pro 
    370                 375                 380                 


Ser Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu 
385                 390                 395                 400 


Val Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly 
                405                 410                 415     


Leu Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg 
            420                 425                 430         


Pro Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly 
        435                 440                 445             


His Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Leu Cys Arg Leu 
    450                 455                 460                 


Asp Ala Glu Pro Arg Pro Pro Pro Thr Gln Glu Ala Ala 
465                 470                 475         


<210> 7464
<211> 1064
<212> PRT
<213> Homo sapiens

<400> 7464
Met Pro Val Gln Ala Ala Gln Trp Thr Glu Phe Leu Ser Cys Pro Ile 
1               5                   10                  15      


Cys Tyr Asn Glu Phe Asp Glu Asn Val His Lys Pro Ile Ser Leu Gly 
            20                  25                  30          


Cys Ser His Thr Val Cys Lys Thr Cys Leu Asn Lys Leu His Arg Lys 
        35                  40                  45              


Ala Cys Pro Phe Asp Gln Thr Ala Ile Asn Thr Asp Ile Asp Val Leu 
    50                  55                  60                  


Pro Val Asn Phe Ala Leu Leu Gln Leu Val Gly Ala Gln Val Pro Asp 
65                  70                  75                  80  


His Gln Ser Ile Lys Leu Ser Asn Leu Gly Glu Asn Lys His Tyr Glu 
                85                  90                  95      


Val Ala Lys Lys Cys Val Glu Asp Leu Ala Leu Tyr Leu Lys Pro Leu 
            100                 105                 110         


Ser Gly Gly Lys Gly Val Ala Ser Leu Asn Gln Ser Ala Leu Ser Arg 
        115                 120                 125             


Pro Met Gln Arg Lys Leu Val Thr Leu Val Asn Cys Gln Leu Val Glu 
    130                 135                 140                 


Glu Glu Gly Arg Val Arg Ala Met Arg Ala Ala Arg Ser Leu Gly Glu 
145                 150                 155                 160 


Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro Gln Gln Leu 
                165                 170                 175     


Ser Ala Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys Gln Phe Leu 
            180                 185                 190         


Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu Leu Ala Leu 
        195                 200                 205             


Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu Phe Val Val 
    210                 215                 220                 


Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr Ser Ile Gly 
225                 230                 235                 240 


His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys Val Thr Lys 
                245                 250                 255     


Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu Phe Arg Ser 
            260                 265                 270         


Tyr Glu Ala Leu Arg Arg Glu His Asp Ala Gln Ile Val His Ile Ala 
        275                 280                 285             


Met Glu Ala Gly Leu Arg Ile Ser Pro Glu Gln Trp Ser Ser Leu Leu 
    290                 295                 300                 


Tyr Gly Asp Leu Ala His Lys Ser His Met Gln Ser Ile Ile Asp Lys 
305                 310                 315                 320 


Leu Gln Ser Pro Glu Ser Phe Ala Lys Ser Val Gln Glu Leu Thr Ile 
                325                 330                 335     


Val Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg Leu Arg Pro 
            340                 345                 350         


His Leu Glu Leu Leu Ala Asn Ile Asp Pro Asn Pro Asp Ala Val Ser 
        355                 360                 365             


Pro Thr Trp Glu Gln Leu Glu Asn Ala Met Val Ala Val Lys Thr Val 
    370                 375                 380                 


Val His Gly Leu Val Asp Phe Ile Gln Asn Tyr Ser Arg Lys Gly His 
385                 390                 395                 400 


Glu Thr Pro Gln Pro Gln Pro Asn Ser Lys Tyr Lys Thr Ser Met Cys 
                405                 410                 415     


Arg Asp Leu Arg Gln Gln Gly Gly Cys Pro Arg Gly Thr Asn Cys Thr 
            420                 425                 430         


Phe Ala His Ser Gln Glu Glu Leu Glu Lys Tyr Arg Leu Arg Asn Lys 
        435                 440                 445             


Lys Ile Asn Ala Thr Val Arg Thr Phe Pro Leu Leu Asn Lys Val Gly 
    450                 455                 460                 


Val Asn Asn Thr Val Thr Thr Thr Ala Gly Asn Val Ile Ser Val Ile 
465                 470                 475                 480 


Gly Ser Thr Glu Thr Thr Gly Lys Ile Val Pro Ser Thr Asn Gly Ile 
                485                 490                 495     


Ser Asn Ala Glu Asn Ser Val Ser Gln Leu Ile Ser Arg Ser Thr Asp 
            500                 505                 510         


Ser Thr Leu Arg Ala Leu Glu Thr Val Lys Lys Val Gly Lys Val Gly 
        515                 520                 525             


Ala Asn Gly Gln Asn Ala Ala Gly Pro Ser Ala Asp Ser Val Thr Glu 
    530                 535                 540                 


Asn Lys Ile Gly Ser Pro Pro Lys Thr Pro Val Ser Asn Val Ala Ala 
545                 550                 555                 560 


Thr Ser Ala Gly Pro Ser Asn Val Gly Thr Glu Leu Asn Ser Val Pro 
                565                 570                 575     


Gln Lys Ser Ser Pro Phe Leu Thr Arg Val Pro Val Tyr Pro Pro His 
            580                 585                 590         


Ser Glu Asn Ile Gln Tyr Phe Gln Asp Pro Arg Thr Gln Ile Pro Phe 
        595                 600                 605             


Glu Val Pro Gln Tyr Pro Gln Thr Gly Tyr Tyr Pro Pro Pro Pro Thr 
    610                 615                 620                 


Val Pro Ala Gly Val Ala Pro Cys Val Pro Arg Phe Val Arg Ser Asn 
625                 630                 635                 640 


Asn Val Pro Glu Ser Ser Leu Pro Pro Ala Ser Met Pro Tyr Ala Asp 
                645                 650                 655     


His Tyr Ser Thr Phe Ser Pro Arg Asp Arg Met Asn Ser Ser Pro Tyr 
            660                 665                 670         


Gln Pro Pro Pro Pro Gln Pro Tyr Gly Pro Val Pro Pro Val Pro Ser 
        675                 680                 685             


Gly Met Tyr Ala Pro Val Tyr Asp Ser Arg Arg Ile Trp Arg Pro Pro 
    690                 695                 700                 


Met Tyr Gln Arg Asp Asp Ile Ile Arg Ser Asn Ser Leu Pro Pro Met 
705                 710                 715                 720 


Asp Val Met His Ser Ser Val Tyr Gln Thr Ser Leu Arg Glu Arg Tyr 
                725                 730                 735     


Asn Ser Leu Asp Gly Tyr Tyr Ser Val Ala Cys Gln Pro Pro Ser Glu 
            740                 745                 750         


Pro Arg Thr Thr Val Pro Leu Pro Arg Glu Pro Cys Gly His Leu Lys 
        755                 760                 765             


Thr Ser Cys Glu Glu Gln Ile Arg Arg Lys Pro Asp Gln Trp Ala Gln 
    770                 775                 780                 


Tyr His Thr Gln Lys Ala Pro Leu Val Ser Ser Thr Leu Pro Val Ala 
785                 790                 795                 800 


Thr Gln Ser Pro Thr Pro Pro Ser Pro Leu Phe Ser Val Asp Phe Arg 
                805                 810                 815     


Ala Asp Phe Ser Glu Ser Val Ser Gly Thr Lys Phe Glu Glu Asp His 
            820                 825                 830         


Leu Ser His Tyr Ser Pro Trp Ser Cys Gly Thr Ile Gly Ser Cys Ile 
        835                 840                 845             


Asn Ala Ile Asp Ser Glu Pro Lys Asp Val Ile Ala Asn Ser Asn Ala 
    850                 855                 860                 


Val Leu Met Asp Leu Asp Ser Gly Asp Val Lys Arg Arg Val His Leu 
865                 870                 875                 880 


Phe Glu Thr Gln Arg Arg Thr Lys Glu Glu Asp Pro Ile Ile Pro Phe 
                885                 890                 895     


Ser Asp Gly Pro Ile Ile Ser Lys Trp Gly Ala Ile Ser Arg Ser Ser 
            900                 905                 910         


Arg Thr Gly Tyr His Thr Thr Asp Pro Val Gln Ala Thr Ala Ser Gln 
        915                 920                 925             


Gly Ser Ala Thr Lys Pro Ile Ser Val Ser Asp Tyr Val Pro Tyr Val 
    930                 935                 940                 


Asn Ala Val Asp Ser Arg Trp Ser Ser Tyr Gly Asn Glu Ala Thr Ser 
945                 950                 955                 960 


Ser Ala His Tyr Val Glu Arg Asp Arg Phe Ile Val Thr Asp Leu Ser 
                965                 970                 975     


Gly His Arg Lys His Ser Ser Thr Gly Asp Leu Leu Ser Leu Glu Leu 
            980                 985                 990         


Gln Gln Ala Lys Ser Asn Ser Leu  Leu Leu Gln Arg Glu  Ala Asn Ala 
        995                 1000                 1005             


Leu Ala  Met Gln Gln Lys Trp  Asn Ser Leu Asp Glu  Gly Arg His 
    1010                 1015                 1020             


Leu Thr  Leu Asn Leu Leu Ser  Lys Glu Ile Glu Leu  Arg Asn Gly 
    1025                 1030                 1035             


Glu Val  Lys Lys Leu Asn Leu  Ser Ala Ser Cys Leu  Met Tyr Leu 
    1040                 1045                 1050             


Phe Ser  Ala Ala Ala Ser Trp  Leu Tyr His Tyr 
    1055                 1060                 


<210> 7465
<211> 515
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7465
Xaa Ala Gly Gly Ser Pro Ser Val Val Asp Tyr Phe Pro Ser Glu Asp 
1               5                   10                  15      


Phe Tyr Arg Cys Gly Tyr Cys Lys Asn Glu Ser Gly Ser Arg Ser Asn 
            20                  25                  30          


Gly Met Trp Ala His Ser Met Thr Val Gln Asp Tyr Gln Asp Leu Ile 
        35                  40                  45              


Asp Arg Gly Trp Arg Arg Ser Gly Lys Tyr Val Tyr Lys Pro Val Met 
    50                  55                  60                  


Asn Gln Thr Cys Cys Pro Gln Tyr Thr Ile Arg Cys Arg Pro Leu Gln 
65                  70                  75                  80  


Phe Gln Pro Ser Lys Ser His Lys Lys Val Leu Lys Lys Met Leu Lys 
                85                  90                  95      


Phe Leu Ala Lys Gly Glu Val Pro Lys Gly Ser Cys Glu Asp Glu Pro 
            100                 105                 110         


Met Asp Ser Thr Met Asp Asp Ala Val Ala Gly Asp Phe Ala Leu Ile 
        115                 120                 125             


Asn Lys Leu Asp Ile Gln Cys Asp Leu Lys Thr Leu Ser Asp Asp Ile 
    130                 135                 140                 


Lys Glu Ser Leu Glu Ser Glu Gly Lys Asn Ser Lys Lys Glu Glu Pro 
145                 150                 155                 160 


Gln Glu Leu Leu Gln Ser Gln Asp Phe Val Gly Glu Lys Leu Gly Ser 
                165                 170                 175     


Gly Glu Pro Ser His Ser Val Lys Val His Thr Val Pro Lys Pro Gly 
            180                 185                 190         


Lys Gly Ala Asp Leu Ser Lys Pro Pro Cys Arg Lys Ala Lys Glu Ile 
        195                 200                 205             


Arg Lys Glu Arg Lys Arg Leu Lys Leu Met Gln Gln Asn Pro Ala Gly 
    210                 215                 220                 


Glu Leu Glu Gly Phe Gln Ala Gln Gly His Pro Pro Ser Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Ala Lys Ser Asn Gln Pro Lys Ser Leu Glu Asp Leu Ile Phe 
                245                 250                 255     


Glu Ser Leu Pro Glu Asn Ala Ser His Lys Leu Glu Val Arg Val Val 
            260                 265                 270         


Arg Ser Ser Pro Pro Ser Ser Gln Phe Lys Ala Thr Leu Leu Glu Ser 
        275                 280                 285             


Tyr Gln Val Tyr Lys Arg Tyr Gln Met Val Ile His Lys Asn Pro Pro 
    290                 295                 300                 


Asp Thr Pro Thr Glu Ser Gln Phe Thr Arg Phe Leu Cys Ser Ser Pro 
305                 310                 315                 320 


Leu Glu Ala Glu Thr Pro Pro Asn Gly Pro Asp Cys Gly Tyr Gly Ser 
                325                 330                 335     


Phe His Gln Gln Tyr Trp Leu Asp Gly Lys Ile Ile Ala Val Gly Val 
            340                 345                 350         


Ile Asp Ile Leu Pro Asn Cys Val Ser Ser Val Tyr Leu Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Tyr Ser Phe Leu Ser Leu Gly Val Tyr Ser Ala Leu Arg Glu 
    370                 375                 380                 


Ile Ala Phe Thr Arg Gln Leu His Glu Lys Thr Ser Gln Leu Ser Tyr 
385                 390                 395                 400 


Tyr Tyr Met Gly Phe Tyr Ile His Ser Cys Pro Lys Met Lys Tyr Lys 
                405                 410                 415     


Gly Gln Tyr Arg Pro Ser Asp Leu Leu Cys Pro Glu Thr Tyr Val Trp 
            420                 425                 430         


Val Pro Ile Glu Gln Cys Leu Pro Ser Leu Glu Asn Ser Lys Tyr Cys 
        435                 440                 445             


Arg Phe Asn Gln Asp Pro Glu Ala Val Asp Glu Asp Arg Ser Thr Glu 
    450                 455                 460                 


Pro Asp Arg Leu Gln Val Phe His Lys Arg Ala Ile Met Pro Tyr Gly 
465                 470                 475                 480 


Val Tyr Lys Lys Gln Gln Lys Asp Pro Ser Glu Glu Ala Ala Val Leu 
                485                 490                 495     


Gln Tyr Ala Ser Leu Val Gly Gln Lys Cys Ser Glu Arg Met Leu Leu 
            500                 505                 510         


Phe Arg Asn 
        515 


<210> 7466
<211> 74
<212> PRT
<213> Homo sapiens

<400> 7466
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro 
65                  70                  


<210> 7467
<211> 197
<212> PRT
<213> Homo sapiens

<400> 7467
Met Ala Ala Phe Arg Asp Ile Glu Glu Val Ser Gln Gly Leu Leu Ser 
1               5                   10                  15      


Leu Leu Gly Ala Asn Arg Ala Glu Ala Gln Gln Arg Arg Leu Leu Gly 
            20                  25                  30          


Arg His Glu Gln Val Val Glu Arg Leu Leu Glu Thr Gln Asp Gly Ala 
        35                  40                  45              


Glu Lys Gln Leu Arg Glu Ile Leu Thr Met Glu Lys Glu Val Ala Gln 
    50                  55                  60                  


Ser Leu Leu Asn Ala Lys Glu Gln Val His Gln Gly Gly Val Glu Leu 
65                  70                  75                  80  


Gln Gln Leu Glu Ala Gly Leu Gln Glu Ala Gly Glu Glu Asp Thr Arg 
                85                  90                  95      


Leu Lys Ala Ser Leu Leu Gln Leu Thr Arg Glu Leu Glu Glu Leu Lys 
            100                 105                 110         


Glu Ile Glu Ala Asp Leu Glu Arg Gln Glu Lys Glu Val Asp Glu Asp 
        115                 120                 125             


Thr Thr Val Thr Ile Pro Ser Ala Val Tyr Val Ala Gln Leu Tyr His 
    130                 135                 140                 


Gln Val Ser Lys Ile Glu Trp Asp Tyr Glu Cys Glu Pro Gly Met Val 
145                 150                 155                 160 


Lys Gly Ile His His Gly Pro Ser Val Ala Gln Pro Ile His Leu Asp 
                165                 170                 175     


Ser Thr Gln Leu Ser Arg Lys Phe Ile Ser Asp Tyr Leu Trp Ser Leu 
            180                 185                 190         


Val Asp Thr Glu Trp 
        195         


<210> 7468
<211> 756
<212> PRT
<213> Homo sapiens

<400> 7468
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr 
1               5                   10                  15      


Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val 
            20                  25                  30          


Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His Gly Gln Asn 
        35                  40                  45              


Asn Pro Val Gly Asp Tyr Glu His Ala Asp Asp Gln Ala Glu Glu Asp 
    50                  55                  60                  


Ala Leu Gln Met Ala Val Gly Tyr Phe Glu Lys Gly Pro Ile Lys Ala 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Thr Leu Glu Lys His Leu Lys Thr Val Glu 
                85                  90                  95      


Asn Val Ala Trp Lys Asn Gly Leu Ala Ser Glu Glu Ile Asp Ile Leu 
            100                 105                 110         


Leu Asn Ile Ala Leu Ser Gly Lys Phe Gly Asn Ala Val Asn Thr Arg 
        115                 120                 125             


Ile Leu Lys Cys Met Ile Pro Ala Thr Val Ile Ser Glu Asp Ser Val 
    130                 135                 140                 


Val Lys Ala Val Ser Trp Leu Cys Val Gly Lys Cys Ser Gly Ser Thr 
145                 150                 155                 160 


Lys Val Leu Phe Tyr Arg Trp Leu Val Ala Met Phe Asp Phe Ile Asp 
                165                 170                 175     


Arg Lys Glu Gln Ile Asn Leu Leu Tyr Gly Phe Phe Phe Ala Ser Leu 
            180                 185                 190         


Gln Asp Asp Ala Leu Cys Pro Tyr Val Cys His Leu Leu Tyr Leu Leu 
        195                 200                 205             


Thr Lys Lys Glu Asn Val Lys Pro Phe Arg Val Arg Lys Leu Leu Asp 
    210                 215                 220                 


Leu Gln Ala Lys Met Gly Met Gln Pro His Leu Gln Ala Leu Leu Ser 
225                 230                 235                 240 


Leu Tyr Lys Phe Phe Ala Pro Ala Leu Ile Ser Val Ser Leu Pro Val 
                245                 250                 255     


Arg Lys Lys Ile Tyr Phe Lys Asn Ser Glu Asn Leu Trp Lys Thr Ala 
            260                 265                 270         


Leu Leu Ala Val Lys Gln Arg Asn Arg Gly Pro Ser Pro Glu Pro Leu 
        275                 280                 285             


Lys Leu Met Leu Gly Pro Ala Asn Val Arg Pro Leu Lys Arg Lys Trp 
    290                 295                 300                 


Asn Ser Leu Ser Val Ile Pro Val Leu Asn Ser Ser Ser Tyr Thr Lys 
305                 310                 315                 320 


Glu Cys Gly Lys Lys Glu Met Ser Leu Ser Asp Cys Leu Asn Arg Ser 
                325                 330                 335     


Gly Ser Phe Pro Leu Glu Gln Leu Gln Ser Phe Pro Gln Leu Leu Gln 
            340                 345                 350         


Asn Ile His Cys Leu Glu Leu Pro Ser Gln Met Gly Ser Val Leu Asn 
        355                 360                 365             


Asn Ser Leu Leu Leu His Tyr Ile Asn Cys Val Arg Asp Glu Pro Val 
    370                 375                 380                 


Leu Leu Arg Phe Tyr Tyr Trp Leu Ser Gln Thr Leu Gln Glu Glu Cys 
385                 390                 395                 400 


Ile Trp Tyr Lys Val Asn Asn Tyr Glu His Gly Lys Glu Phe Thr Asn 
                405                 410                 415     


Phe Leu Asp Thr Ile Ile Arg Ala Glu Cys Phe Leu Gln Glu Gly Phe 
            420                 425                 430         


Tyr Ser Cys Glu Ala Phe Leu Tyr Lys Ser Leu Pro Leu Trp Asp Gly 
        435                 440                 445             


Leu Cys Cys Arg Ser Gln Phe Leu Gln Leu Val Ser Trp Ile Pro Phe 
    450                 455                 460                 


Ser Ser Phe Ser Glu Val Lys Pro Leu Leu Phe Asp His Leu Ala Gln 
465                 470                 475                 480 


Leu Phe Phe Thr Ser Thr Ile Tyr Phe Lys Cys Ser Val Leu Gln Ser 
                485                 490                 495     


Leu Lys Glu Leu Leu Gln Asn Trp Leu Leu Trp Leu Ser Met Asp Ile 
            500                 505                 510         


His Met Lys Pro Val Thr Asn Ser Pro Leu Glu Thr Thr Leu Gly Gly 
        515                 520                 525             


Ser Met Asn Ser Val Ser Lys Leu Ile His Tyr Val Gly Trp Leu Ser 
    530                 535                 540                 


Thr Thr Ala Met Arg Leu Glu Ser Asn Asn Thr Phe Leu Leu His Phe 
545                 550                 555                 560 


Ile Leu Asp Phe Tyr Glu Lys Val Cys Asp Ile Tyr Ile Asn Tyr Asn 
                565                 570                 575     


Leu Pro Leu Val Val Leu Phe Pro Pro Gly Ile Phe Tyr Ser Ala Leu 
            580                 585                 590         


Leu Ser Leu Asp Thr Ser Ile Leu Asn Gln Leu Cys Phe Ile Met His 
        595                 600                 605             


Arg Tyr Arg Lys Asn Leu Thr Ala Ala Lys Lys Asn Glu Leu Val Gln 
    610                 615                 620                 


Lys Thr Lys Ser Glu Phe Asn Phe Ser Ser Lys Thr Tyr Gln Glu Phe 
625                 630                 635                 640 


Asn His Tyr Leu Thr Ser Met Val Gly Cys Leu Trp Thr Ser Lys Pro 
                645                 650                 655     


Phe Gly Lys Gly Ile Tyr Ile Asp Pro Glu Ile Leu Glu Lys Thr Gly 
            660                 665                 670         


Val Ala Glu Tyr Lys Asn Ser Leu Asn Val Val His His Pro Ser Phe 
        675                 680                 685             


Leu Ser Tyr Ala Val Ser Phe Leu Leu Gln Glu Ser Pro Glu Glu Arg 
    690                 695                 700                 


Thr Val Asn Val Ser Ser Ile Arg Gly Lys Lys Trp Ser Trp Tyr Leu 
705                 710                 715                 720 


Asp Tyr Leu Phe Ser Gln Gly Leu Gln Gly Leu Lys Leu Phe Ile Arg 
                725                 730                 735     


Ser Ser Val His His Ser Ser Ile Pro Arg Ala Glu Gly Ile Asn Cys 
            740                 745                 750         


Asn Asn Gln Tyr 
        755     


<210> 7469
<211> 646
<212> PRT
<213> Homo sapiens

<400> 7469
Ala Gln Gly Ser Val Ser Phe Asn Asp Val Thr Val Asp Phe Thr Gln 
1               5                   10                  15      


Glu Glu Trp Gln His Leu Asp His Ala Gln Lys Thr Leu Tyr Met Asp 
            20                  25                  30          


Val Met Leu Glu Asn Tyr Cys His Leu Ile Ser Val Gly Cys His Met 
        35                  40                  45              


Thr Lys Pro Asp Val Ile Leu Lys Leu Glu Arg Gly Glu Glu Pro Trp 
    50                  55                  60                  


Thr Ser Phe Ala Gly His Thr Cys Leu Glu Glu Asn Trp Lys Ala Glu 
65                  70                  75                  80  


Asp Phe Leu Val Lys Phe Lys Glu His Gln Glu Lys Tyr Ser Arg Ser 
                85                  90                  95      


Val Val Ser Ile Asn His Lys Lys Leu Val Lys Glu Lys Ser Lys Ile 
            100                 105                 110         


Tyr Glu Lys Thr Phe Thr Leu Gly Lys Asn Pro Val Asn Ser Lys Asn 
        115                 120                 125             


Leu Pro Pro Glu Tyr Asp Thr His Gly Arg Ile Leu Lys Asn Val Ser 
    130                 135                 140                 


Glu Leu Ile Ile Ser Asn Leu Asn Pro Ala Arg Lys Arg Leu Ser Glu 
145                 150                 155                 160 


Tyr Asn Gly Tyr Gly Lys Ser Leu Leu Ser Thr Lys Gln Glu Thr Thr 
                165                 170                 175     


His Pro Glu Val Lys Ser His Asn Gln Ser Ala Arg Ala Phe Ser His 
            180                 185                 190         


Asn Glu Val Leu Met Gln Tyr Gln Lys Thr Glu Thr Pro Ala Gln Ser 
        195                 200                 205             


Phe Gly Tyr Asn Asp Cys Glu Lys Ser Phe Leu Gln Arg Gly Gly Leu 
    210                 215                 220                 


Ile Thr His Ser Arg Pro Tyr Lys Gly Glu Asn Pro Ser Val Tyr Asn 
225                 230                 235                 240 


Lys Lys Arg Arg Ala Thr Asn Ile Glu Lys Lys His Thr Cys Asn Glu 
                245                 250                 255     


Cys Gly Lys Ser Phe Cys Arg Lys Ser Val Leu Ile Leu His Gln Gly 
            260                 265                 270         


Ile His Ser Glu Glu Lys Pro Tyr Gln Cys His Gln Cys Gly Asn Ala 
        275                 280                 285             


Phe Arg Arg Lys Ser Tyr Leu Ile Asp His Gln Arg Thr His Thr Gly 
    290                 295                 300                 


Glu Lys Pro Phe Val Cys Asn Glu Cys Gly Lys Ser Phe Arg Leu Lys 
305                 310                 315                 320 


Thr Ala Leu Thr Asp His Gln Arg Thr His Thr Gly Glu Lys Ser Tyr 
                325                 330                 335     


Glu Cys Leu Gln Cys Arg Asn Ala Phe Arg Leu Lys Ser His Leu Ile 
            340                 345                 350         


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Asp 
        355                 360                 365             


Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu Ser Leu His Gln Arg 
    370                 375                 380                 


Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Lys Glu Cys Gly Lys Ser 
385                 390                 395                 400 


Phe His Gln Lys Ala Asn Leu Thr Val His Gln Arg Thr His Thr Gly 
                405                 410                 415     


Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Ser Gln Lys 
            420                 425                 430         


Thr Thr Leu Ala Leu His Glu Lys Thr His Asn Glu Glu Lys Pro Tyr 
        435                 440                 445             


Ile Cys Ser Glu Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu Val 
    450                 455                 460                 


Ala His Gln Arg Thr His Thr Gly Glu Lys Ser Tyr Glu Cys Pro His 
465                 470                 475                 480 


Cys Gly Lys Ala Phe Arg Met Lys Ser Tyr Leu Ile Asp His His Arg 
                485                 490                 495     


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser 
            500                 505                 510         


Phe Ser Gln Lys Thr Asn Leu Asn Leu His Gln Arg Ile His Thr Gly 
        515                 520                 525             


Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ser Phe Arg Gln Lys 
    530                 535                 540                 


Ala Thr Leu Thr Val His Gln Lys Ile His Thr Gly Gln Lys Ser Tyr 
545                 550                 555                 560 


Glu Cys Pro Gln Cys Gly Lys Ala Phe Ser Arg Lys Ser Tyr Leu Ile 
                565                 570                 575     


His His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Glu 
            580                 585                 590         


Cys Gly Lys Cys Phe Arg Gln Lys Thr Asn Leu Ile Val His Gln Arg 
        595                 600                 605             


Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ser 
    610                 615                 620                 


Phe Ser Tyr Lys Arg Asn Leu Ile Val His Gln Arg Thr His Lys Gly 
625                 630                 635                 640 


Glu Asn Ile Glu Met Gln 
                645     


<210> 7470
<211> 197
<212> PRT
<213> Homo sapiens

<400> 7470
Met Gly Gly Arg Lys Arg Glu Arg Lys Ala Ala Val Glu Glu Asp Thr 
1               5                   10                  15      


Ser Leu Ser Glu Ser Glu Gly Pro Arg Gln Pro Asp Gly Asp Glu Glu 
            20                  25                  30          


Glu Ser Thr Ala Leu Ser Ile Asn Glu Glu Met Gln Arg Met Leu Asn 
        35                  40                  45              


Gln Leu Arg Glu Tyr Asp Phe Glu Asp Asp Cys Asp Ser Leu Thr Trp 
    50                  55                  60                  


Glu Glu Thr Glu Glu Thr Leu Leu Leu Trp Glu Asp Phe Ser Gly Tyr 
65                  70                  75                  80  


Ala Met Ala Ala Ala Glu Ala Gln Gly Glu Gln Glu Asp Ser Leu Glu 
                85                  90                  95      


Lys Val Ile Lys Asp Thr Glu Ser Leu Phe Lys Thr Arg Glu Lys Glu 
            100                 105                 110         


Tyr Gln Glu Thr Ile Asp Gln Ile Glu Leu Glu Leu Ala Thr Ala Lys 
        115                 120                 125             


Asn Asp Met Asn Arg His Leu His Glu Tyr Met Glu Met Cys Ser Met 
    130                 135                 140                 


Lys Arg Gly Leu Asp Val Gln Met Glu Thr Cys Arg Arg Leu Ile Thr 
145                 150                 155                 160 


Gln Ser Gly Asp Arg Lys Ser Pro Ala Phe Thr Ala Val Pro Leu Ser 
                165                 170                 175     


Asp Pro Pro Pro Arg Gln Ala Arg Leu Arg Thr Pro Ile Ala Met Ser 
            180                 185                 190         


His Leu Thr Ala Pro 
        195         


<210> 7471
<211> 140
<212> PRT
<213> Homo sapiens

<400> 7471
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 
            100                 105                 110         


Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 
        115                 120                 125             


Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn 
    130                 135                 140 


<210> 7472
<211> 1078
<212> PRT
<213> Homo sapiens

<400> 7472
Val Cys Met His Pro His Asn Val Leu Ser Asp Val Val Asn Tyr Thr 
1               5                   10                  15      


Leu Trp Leu Met Glu Cys Ser His Ala Ser Gly Cys Cys His Ala Thr 
            20                  25                  30          


Met Phe Phe Ser Ile Cys Phe Ser Phe Arg Ala Val Leu Glu Leu Phe 
        35                  40                  45              


Asp Arg Tyr Asp Gly Leu Arg Arg Leu Val Asn Leu Ile Ser Thr Leu 
    50                  55                  60                  


Glu Ile Leu Asn Leu Glu Asp Gln Gly Ala Leu Leu Ser Asp Asp Glu 
65                  70                  75                  80  


Ile Phe Ala Ser Arg Gln Thr Gly Lys His Thr Cys Met Ala Leu Arg 
                85                  90                  95      


Lys Tyr Phe Glu Ala His Leu Ala Ile Lys Leu Glu Gln Val Lys Gln 
            100                 105                 110         


Ser Leu Gln Arg Thr Glu Gly Gly Ile Leu Val His Pro Gln Pro Pro 
        115                 120                 125             


Tyr Lys Ala Cys Ser Tyr Thr His Glu Gln Ile Val Glu Met Met Glu 
    130                 135                 140                 


Phe Leu Ile Glu Tyr Gly Pro Ala Gln Leu Tyr Trp Glu Pro Ala Glu 
145                 150                 155                 160 


Val Phe Leu Lys Leu Ser Cys Val Gln Leu Leu Leu Gln Leu Ile Ser 
                165                 170                 175     


Ile Ala Cys Asn Trp Lys Thr Tyr Tyr Ala Arg Asn Asp Thr Val Arg 
            180                 185                 190         


Phe Ala Leu Asp Val Leu Ala Ile Leu Thr Val Val Pro Lys Ile Gln 
        195                 200                 205             


Leu Gln Leu Ala Glu Ser Val Asp Val Leu Asp Glu Ala Gly Ser Thr 
    210                 215                 220                 


Val Ser Thr Val Gly Ile Ser Ile Ile Leu Gly Val Ala Glu Gly Glu 
225                 230                 235                 240 


Phe Phe Ile His Asp Ala Glu Ile Gln Lys Ser Ala Leu Gln Ile Ile 
                245                 250                 255     


Ile Asn Cys Val Cys Gly Pro Asp Asn Arg Ile Ser Ser Ile Gly Lys 
            260                 265                 270         


Phe Ile Ser Gly Thr Pro Arg Arg Lys Leu Pro Gln Asn Pro Lys Ser 
        275                 280                 285             


Ser Glu His Thr Leu Ala Lys Met Trp Asn Val Val Gln Ser Asn Asn 
    290                 295                 300                 


Gly Ile Lys Val Leu Leu Ser Leu Leu Ser Ile Lys Met Pro Ile Thr 
305                 310                 315                 320 


Asp Ala Asp Gln Ile Arg Ala Leu Ala Cys Lys Ala Leu Val Gly Leu 
                325                 330                 335     


Ser Arg Ser Ser Thr Val Arg Gln Ile Ile Ser Lys Leu Pro Leu Phe 
            340                 345                 350         


Ser Ser Cys Gln Ile Gln Gln Leu Met Lys Glu Pro Val Leu Gln Asp 
        355                 360                 365             


Lys Arg Ser Asp His Val Lys Phe Cys Lys Tyr Ala Ala Glu Leu Ile 
    370                 375                 380                 


Glu Arg Val Ser Gly Lys Pro Leu Leu Ile Gly Thr Asp Val Ser Leu 
385                 390                 395                 400 


Ala Arg Leu Gln Lys Ala Asp Val Val Ala Gln Ser Arg Ile Ser Phe 
                405                 410                 415     


Pro Glu Lys Glu Leu Leu Leu Leu Ile Arg Asn His Leu Ile Ser Lys 
            420                 425                 430         


Gly Leu Gly Glu Thr Ala Thr Val Leu Thr Lys Glu Ala Asp Leu Pro 
        435                 440                 445             


Met Thr Ala Ala Ser His Ser Ser Ala Phe Thr Pro Val Thr Ala Ala 
    450                 455                 460                 


Ala Ser Pro Val Ser Leu Pro Arg Thr Pro Arg Ile Ala Asn Gly Ile 
465                 470                 475                 480 


Ala Thr Arg Leu Gly Ser His Ala Ala Val Gly Ala Ser Ala Pro Ser 
                485                 490                 495     


Ala Pro Thr Ala His Pro Gln Pro Arg Pro Pro Gln Gly Pro Leu Ala 
            500                 505                 510         


Leu Pro Gly Pro Ser Tyr Ala Gly Asn Ser Pro Leu Ile Gly Arg Ile 
        515                 520                 525             


Ser Phe Ile Arg Glu Arg Pro Ser Pro Cys Asn Gly Arg Lys Ile Arg 
    530                 535                 540                 


Val Leu Arg Gln Lys Ser Asp His Gly Ala Tyr Ser Gln Ser Pro Ala 
545                 550                 555                 560 


Ile Lys Lys Gln Leu Asp Arg His Leu Pro Ser Pro Pro Thr Leu Asp 
                565                 570                 575     


Ser Ile Ile Thr Glu Tyr Leu Arg Glu Gln His Ala Arg Cys Lys Asn 
            580                 585                 590         


Pro Val Ala Thr Cys Pro Pro Phe Ser Leu Phe Thr Pro His Gln Cys 
        595                 600                 605             


Pro Glu Pro Lys Gln Arg Arg Gln Ala Pro Ile Asn Phe Thr Ser Arg 
    610                 615                 620                 


Leu Asn Arg Arg Ala Ser Phe Pro Lys Tyr Gly Gly Val Asp Gly Gly 
625                 630                 635                 640 


Cys Phe Asp Arg His Leu Ile Phe Ser Arg Phe Arg Pro Ile Ser Val 
                645                 650                 655     


Phe Arg Glu Ala Asn Glu Asp Glu Ser Gly Phe Thr Cys Cys Ala Phe 
            660                 665                 670         


Ser Ala Arg Glu Arg Phe Leu Met Leu Gly Thr Cys Thr Gly Gln Leu 
        675                 680                 685             


Lys Leu Tyr Asn Val Phe Ser Gly Gln Glu Glu Ala Ser Tyr Asn Cys 
    690                 695                 700                 


His Asn Ser Ala Ile Thr His Leu Glu Pro Ser Arg Asp Gly Ser Leu 
705                 710                 715                 720 


Leu Leu Thr Ser Ala Thr Trp Ser Gln Pro Leu Ser Ala Leu Trp Gly 
                725                 730                 735     


Met Lys Ser Val Phe Asp Met Lys His Ser Phe Thr Glu Asp His Tyr 
            740                 745                 750         


Val Glu Phe Ser Lys His Ser Gln Asp Arg Val Ile Gly Thr Lys Gly 
        755                 760                 765             


Asp Ile Ala His Ile Tyr Asp Ile Gln Thr Gly Asn Lys Leu Leu Thr 
    770                 775                 780                 


Leu Phe Asn Pro Asp Leu Ala Asn Asn Tyr Lys Arg Asn Cys Ala Thr 
785                 790                 795                 800 


Phe Asn Pro Thr Asp Asp Leu Val Leu Asn Asp Gly Val Leu Trp Asp 
                805                 810                 815     


Val Arg Ser Ala Gln Ala Ile His Lys Phe Asp Lys Phe Asn Met Asn 
            820                 825                 830         


Ile Ser Gly Val Phe His Pro Asn Gly Leu Glu Val Ile Ile Asn Thr 
        835                 840                 845             


Glu Ile Trp Asp Leu Arg Thr Phe His Leu Leu His Thr Val Pro Ala 
    850                 855                 860                 


Leu Asp Gln Cys Arg Val Val Phe Asn His Thr Gly Thr Val Met Tyr 
865                 870                 875                 880 


Gly Ala Met Leu Gln Ala Asp Asp Glu Asp Asp Leu Met Glu Glu Arg 
                885                 890                 895     


Met Lys Ser Pro Phe Gly Ser Ser Phe Arg Thr Phe Asn Ala Thr Asp 
            900                 905                 910         


Tyr Lys Pro Ile Ala Thr Ile Asp Val Lys Arg Asn Ile Phe Asp Leu 
        915                 920                 925             


Cys Thr Asp Thr Lys Asp Cys Tyr Leu Ala Val Ile Glu Asn Gln Gly 
    930                 935                 940                 


Ser Met Asp Ala Leu Asn Met Asp Thr Val Cys Arg Leu Tyr Glu Val 
945                 950                 955                 960 


Gly Arg Gln Arg Leu Ala Glu Asp Glu Asp Glu Glu Glu Asp Gln Glu 
                965                 970                 975     


Glu Glu Glu Gln Glu Glu Glu Asp Asp Asp Glu Asp Asp Asp Asp Thr 
            980                 985                 990         


Asp Asp Leu Asp Glu Leu Asp Thr  Asp Gln Leu Leu Glu  Ala Glu Leu 
        995                 1000                 1005             


Glu Glu  Asp Asp Asn Asn Glu  Asn Ala Gly Glu Asp  Gly Asp Asn 
    1010                 1015                 1020             


Asp Phe  Ser Pro Ser Asp Glu  Glu Leu Ala Asn Leu  Leu Glu Glu 
    1025                 1030                 1035             


Gly Glu  Asp Gly Glu Asp Glu  Asp Ser Asp Ala Asp  Glu Glu Val 
    1040                 1045                 1050             


Glu Leu  Ile Leu Gly Asp Thr  Asp Ser Ser Asp Asn  Ser Asp Leu 
    1055                 1060                 1065             


Glu Asp  Asp Ile Ile Leu Ser  Leu Asn Glu 
    1070                 1075             


<210> 7473
<211> 148
<212> PRT
<213> Homo sapiens

<400> 7473
Met Leu Ser Asp Gly Cys Gly Ser Glu Glu Lys Ile Ser Val Pro Ser 
1               5                   10                  15      


Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser Arg Gln Val Pro Ala Ser 
            20                  25                  30          


His Asp Ser Glu Leu Met Ala Phe Met Thr Arg Lys Leu Trp Asp Leu 
        35                  40                  45              


Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile Leu Ser Lys Asp Gln 
    50                  55                  60                  


Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr Leu Arg Pro His Pro 
65                  70                  75                  80  


Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu Glu Thr Met Cys Val 
                85                  90                  95      


Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg Phe Leu Ser Asp Tyr 
            100                 105                 110         


Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln Glu Asp Ser Glu Ser 
        115                 120                 125             


Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp Met Thr Ala Lys Lys 
    130                 135                 140                 


Phe Trp Lys Pro 
145             


<210> 7474
<211> 584
<212> PRT
<213> Homo sapiens

<400> 7474
Met Ser Leu Pro Pro Glu Lys Ala Ser Glu Leu Lys Gln Leu Ile His 
1               5                   10                  15      


Gln Gln Leu Ser Lys Met Asp Val His Gly Arg Ile Arg Glu Ile Leu 
            20                  25                  30          


Ala Glu Thr Ile Arg Glu Glu Leu Ala Pro Asp Gln Gln His Leu Ser 
        35                  40                  45              


Thr Glu Asp Leu Ile Lys Ala Leu Arg Arg Arg Gly Ile Ile Asp Asp 
    50                  55                  60                  


Val Met Lys Glu Leu Asn Phe Val Thr Asp Ser Val Glu Gln Glu Leu 
65                  70                  75                  80  


Pro Ser Ser Pro Lys Gln Pro Ile Cys Phe Asp Arg Gln Ser Thr Leu 
                85                  90                  95      


Lys Lys Ser Asp Gly Thr Arg Met Ala Asp Ser Thr Thr Met Leu Ser 
            100                 105                 110         


Ile Ser Asp Pro Ile His Met Val Leu Ile Lys Thr Asp Ile Phe Gly 
        115                 120                 125             


Glu Thr Thr Leu Val Ala Ser Tyr Phe Leu Glu Trp Arg Ser Val Leu 
    130                 135                 140                 


Gly Ser Glu Asn Gly Val Thr Ser Leu Thr Val Glu Leu Met Gly Val 
145                 150                 155                 160 


Gly Thr Glu Ser Lys Val Ser Val Gly Ile Leu Asn Ile Lys Leu Glu 
                165                 170                 175     


Met Tyr Pro Pro Leu Asn Gln Thr Leu Ser Gln Glu Val Val Asn Thr 
            180                 185                 190         


Gln Leu Ala Leu Glu Arg Gln Lys Thr Ala Glu Lys Glu Arg Leu Phe 
        195                 200                 205             


Leu Val Tyr Ala Lys Gln Trp Trp Arg Glu Tyr Leu Gln Ile Arg Pro 
    210                 215                 220                 


Ser His Asn Ser Arg Leu Val Lys Ile Phe Ala Gln Asp Glu Asn Gly 
225                 230                 235                 240 


Ile Asn Arg Pro Val Cys Ser Tyr Val Lys Pro Leu Arg Ala Gly Arg 
                245                 250                 255     


Leu Leu Asp Thr Pro Arg Gln Ala Ala Arg Phe Val Asn Val Leu Gly 
            260                 265                 270         


Tyr Glu Arg Ala Pro Val Ile Gly Gly Gly Gly Lys Gln Glu Gln Trp 
        275                 280                 285             


Cys Thr Leu Leu Ala Phe Leu Cys Arg Asn Lys Gly Asp Cys Glu Asp 
    290                 295                 300                 


His Ala Asn Leu Leu Cys Ser Leu Leu Leu Gly Tyr Gly Leu Glu Ala 
305                 310                 315                 320 


Phe Val Cys Val Gly Thr Lys Ala Lys Gly Val Pro His Ala Trp Val 
                325                 330                 335     


Met Thr Cys Gly Thr Asp Gly Ala Ile Thr Phe Trp Glu Ser Leu Thr 
            340                 345                 350         


Gly His Arg Tyr Ile His Lys Pro Thr Asn Pro Asp Glu Pro Pro Val 
        355                 360                 365             


Ala Glu Gln Pro Lys Pro Leu Tyr Pro Tyr Arg Thr Ile Gly Cys Val 
    370                 375                 380                 


Phe Asn His Gln Met Phe Leu Gly Asn Cys Gln Pro Ser Asp Ala Val 
385                 390                 395                 400 


Glu Thr Cys Val Phe Asp Leu Asn Asp Glu Ser Lys Trp Lys Pro Met 
                405                 410                 415     


Ser Glu Glu Ala Ile Lys Ser Val Cys Ala Pro Gly Ala Thr Thr Ser 
            420                 425                 430         


Leu Pro Pro Phe Pro Pro Leu Cys Ala Ser Thr Ile Asp Ala Ser Val 
        435                 440                 445             


Thr Ser Asn Glu Ile Glu Met Gln Leu Arg Leu Leu Val Ser Glu His 
    450                 455                 460                 


Arg Lys Asp Leu Gly Leu Thr Thr Val Trp Glu Asp Gln Leu Ser Tyr 
465                 470                 475                 480 


Leu Leu Ser Pro Ala Leu Ala Ser Tyr Glu Phe Glu Arg Thr Thr Ser 
                485                 490                 495     


Ile Ser Ala Gly Asn Glu Glu Phe Gln Asp Ala Ile Arg Arg Ala Val 
            500                 505                 510         


Pro Asp Gly His Thr Phe Lys Gly Phe Pro Ile His Phe Val Tyr Arg 
        515                 520                 525             


Asn Ala Arg Arg Ala Phe Ala Thr Cys Leu Arg Ser Pro Phe Cys Glu 
    530                 535                 540                 


Glu Ile Ile Cys Cys Arg Gly Asp Gln Val Arg Leu Ala Val Arg Val 
545                 550                 555                 560 


Arg Val Phe Thr Tyr Pro Glu Ser Ala Cys Ala Val Trp Ile Met Phe 
                565                 570                 575     


Ala Cys Lys Tyr Arg Ser Val Leu 
            580                 


<210> 7475
<211> 1504
<212> PRT
<213> Homo sapiens

<400> 7475
Met Val Ser Glu Ser Asp Phe Ser Lys Asp Val Ala Val Gln Val Leu 
1               5                   10                  15      


Pro Leu Asp Lys Ile Glu Glu Asn Asn Lys Gln Lys Ala Asn Asp Ile 
            20                  25                  30          


Phe Ile Ser Gln Tyr Thr Met Gly Gln Lys Asp Ala Leu Arg Thr Val 
        35                  40                  45              


Leu Lys Gln Asn Val Ser Leu Cys Leu Thr Gly Trp Ser Asp His Ser 
    50                  55                  60                  


Gly Val Ile Thr Thr His Cys Ser Leu Tyr Leu Leu Arg Leu Met Arg 
65                  70                  75                  80  


Ser Ser His Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Ala Gln Ser 
                85                  90                  95      


Met Pro Val Phe Lys Glu Val Lys Val His Leu Leu Glu Asp Ala Gly 
            100                 105                 110         


Ile Glu Lys Asp Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser Gly 
        115                 120                 125             


Ile Asp Ser Ala Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile Ala 
    130                 135                 140                 


Thr Ala Ala Pro Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys Val 
145                 150                 155                 160 


Asn Ser Val Thr Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys His 
                165                 170                 175     


Leu Gln Arg Val Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln Glu 
            180                 185                 190         


Lys Leu His Cys His Asp His Glu Lys Gln Met Asn Val Phe Met Glu 
        195                 200                 205             


Gln His Ile Arg His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp Ile 
    210                 215                 220                 


Gln Thr His Phe Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln Pro 
225                 230                 235                 240 


Val Ser Met Pro Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys Pro 
                245                 250                 255     


Glu His Pro Asn Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr Phe 
            260                 265                 270         


Ala Ser Lys Gln Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe Asp 
        275                 280                 285             


Lys Gln Lys Ser Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala Pro 
    290                 295                 300                 


Val Pro Val Ser Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu Leu 
305                 310                 315                 320 


Glu Glu Lys Glu Asn Met Glu Val Ser Cys His Arg Gly Asn Val Arg 
                325                 330                 335     


Leu Leu Glu Gln Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys Ser 
            340                 345                 350         


Glu Ser Ser Asn Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp Thr 
        355                 360                 365             


Pro Glu Lys Thr Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr Thr 
    370                 375                 380                 


Lys Val Thr Met Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly Gln 
385                 390                 395                 400 


Lys Glu Lys Glu Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu Ser 
                405                 410                 415     


Met Leu Lys Leu Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln Thr 
            420                 425                 430         


Thr Asn Thr Thr Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu Arg 
        435                 440                 445             


Gly Val Gln Asn Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala Ile 
    450                 455                 460                 


Ile Arg Ala Lys Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala Leu 
465                 470                 475                 480 


Ser Thr Asn Arg Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr Val 
                485                 490                 495     


Asp Glu Trp Ile Lys Thr Ile Ser Ala Glu Ile Gln Asp Glu Leu Ser 
            500                 505                 510         


Arg Thr Asp Tyr Glu Gln Lys Arg Phe Asp Gln Lys Asn Gln Arg Thr 
        515                 520                 525             


Lys Lys Gly Gln Asn Met Thr Lys Asp Ile Arg Thr Asn Thr Gln Asp 
    530                 535                 540                 


Lys Thr Val Asn Lys Ser Val Ile Pro Arg Lys His Ser Gln Lys Gln 
545                 550                 555                 560 


Ile Glu Glu His Phe Arg Asn Leu Pro Met Arg Gly Met Pro Ala Ser 
                565                 570                 575     


Ser Leu Gln Lys Glu Arg Lys Glu Gly Leu Leu Lys Ala Thr Thr Val 
            580                 585                 590         


Ile Gln Asp Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val Tyr 
        595                 600                 605             


Gln Gly His Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe Asn 
    610                 615                 620                 


Ser Pro Ser Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu Arg 
625                 630                 635                 640 


Val Lys Gly Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe Tyr 
                645                 650                 655     


Ala Thr Lys Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val Pro 
            660                 665                 670         


Val Leu Pro His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg Glu 
        675                 680                 685             


Met Pro Thr Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met Ala 
    690                 695                 700                 


Ile Leu Leu Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro Ala 
705                 710                 715                 720 


Gly Val Ile Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser Ile 
                725                 730                 735     


Pro Pro Ser Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn Ile 
            740                 745                 750         


Ala Ile Val Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu Thr 
        755                 760                 765             


Val Gln Val Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser Ser 
    770                 775                 780                 


Ala Asp Val Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Leu Pro 
785                 790                 795                 800 


Pro Val Gln Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp Glu 
                805                 810                 815     


Glu Glu Val Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp Val 
            820                 825                 830         


Ile Gln Glu Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro Ile 
        835                 840                 845             


Leu Glu Phe Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn Gly 
    850                 855                 860                 


Pro Pro Phe Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp Ile 
865                 870                 875                 880 


Leu Asp Lys Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu Ile 
                885                 890                 895     


Gln Trp Val Glu Gln Glu Ile Met Ser Arg Ile Ile Ser Gly Leu Phe 
            900                 905                 910         


Pro Val Gln Gln Gln Ile Ala Pro Ser Ile Ser Val Ser Val Ser Glu 
        915                 920                 925             


Thr Ser Glu Pro Leu Thr Ser Asp Ile Val Glu Gly Thr Ser Ser Gly 
    930                 935                 940                 


Ala Leu Gln Leu Phe Val Asp Ala Gly Val Pro Val Asn Ser Asn Val 
945                 950                 955                 960 


Ile Lys His Phe Val Asn Glu Ala Leu Ala Glu Thr Ile Ala Val Met 
                965                 970                 975     


Leu Gly Asp Arg Glu Ala Lys Lys Gln Gly Pro Val Ala Thr Gly Val 
            980                 985                 990         


Ser Gly Asp Ala Ser Thr Asn Glu  Thr Tyr Leu Pro Ala  Arg Val Cys 
        995                 1000                 1005             


Thr Pro  Leu Pro Thr Pro Gln  Pro Thr Pro Pro Cys  Ser Pro Ser 
    1010                 1015                 1020             


Ser Pro  Ala Lys Glu Cys Val  Leu Val Lys Thr Pro  Asp Ser Ser 
    1025                 1030                 1035             


Pro Cys  Asp Ser Asp His Asp  Met Ala Phe Pro Val  Lys Glu Ile 
    1040                 1045                 1050             


Cys Ala  Glu Lys Gly Asp Asp  Met Pro Ala Ile Met  Leu Val Asn 
    1055                 1060                 1065             


Thr Pro  Thr Val Thr Pro Thr  Thr Thr Pro Pro Pro  Ala Ala Ala 
    1070                 1075                 1080             


Val Phe  Thr Pro Thr Leu Ser  Asp Ile Ser Ile Asp  Lys Leu Lys 
    1085                 1090                 1095             


Val Ser  Ser Pro Glu Leu Pro  Lys Pro Trp Gly Asp  Gly Asp Leu 
    1100                 1105                 1110             


Pro Leu  Glu Glu Glu Asn Pro  Asn Ser Pro Gln Glu  Glu Leu His 
    1115                 1120                 1125             


Pro Arg  Ala Ile Val Met Ser  Val Ala Lys Asp Glu  Glu Pro Glu 
    1130                 1135                 1140             


Ser Met  Asp Phe Pro Ala Gln  Pro Pro Pro Pro Glu  Pro Val Pro 
    1145                 1150                 1155             


Phe Met  Pro Phe Pro Ala Gly  Thr Lys Ala Pro Ser  Pro Ser Gln 
    1160                 1165                 1170             


Met Pro  Gly Ser Asp Ser Ser  Thr Leu Glu Ser Thr  Leu Ser Val 
    1175                 1180                 1185             


Thr Val  Thr Glu Thr Glu Thr  Leu Asp Lys Pro Ile  Ser Glu Gly 
    1190                 1195                 1200             


Glu Ile  Leu Phe Ser Cys Gly  Gln Lys Leu Ala Pro  Lys Ile Leu 
    1205                 1210                 1215             


Glu Asp  Ile Gly Leu Tyr Leu  Thr Asn Leu Asn Asp  Ser Leu Ser 
    1220                 1225                 1230             


Ser Thr  Leu His Asp Ala Val  Glu Met Glu Asp Asp  Pro Pro Ser 
    1235                 1240                 1245             


Glu Gly  Gln Val Ile Arg Met  Ser His Lys Lys Phe  His Ala Asp 
    1250                 1255                 1260             


Ala Ile  Leu Ser Phe Ala Lys  Gln Asn Gln Glu Ser  Ala Val Ser 
    1265                 1270                 1275             


Gln Gln  Ala Val Tyr His Ser  Glu Asp Leu Glu Asn  Ser Val Gly 
    1280                 1285                 1290             


Glu Leu  Ser Glu Gly Gln Arg  Pro Gln Leu Thr Ala  Ala Ala Glu 
    1295                 1300                 1305             


Asn Ile  Leu Met Gly His Ser  Leu Tyr Met Gln Pro  Pro Val Thr 
    1310                 1315                 1320             


Asn Thr  Gln Ser Leu Asp Gln  Gln Cys Asp Pro Lys  Pro Leu Ser 
    1325                 1330                 1335             


Arg Gln  Phe Asp Thr Val Ser  Gly Ser Ile Tyr Glu  Asp Ser Cys 
    1340                 1345                 1350             


Ala Ser  His Gly Pro Met Ser  Leu Gly Glu Leu Glu  Leu Glu Pro 
    1355                 1360                 1365             


Asn Ser  Lys Leu Val Leu Pro  Thr Thr Leu Leu Thr  Ala Gln Glu 
    1370                 1375                 1380             


Asn Asp  Val Asn Leu Pro Val  Ala Ala Glu Asp Phe  Ser Gln Tyr 
    1385                 1390                 1395             


Gln Leu  Lys Gln Asn Gln Asp  Val Lys Gln Val Glu  His Lys Pro 
    1400                 1405                 1410             


Ser Gln  Ser Tyr Leu Arg Val  Arg Asn Lys Ser Asp  Ile Ala Pro 
    1415                 1420                 1425             


Ser Gln  Gln Gln Val Ser Pro  Gly Asp Met Asp Arg  Thr Gln Ile 
    1430                 1435                 1440             


Glu Leu  Asn Pro Tyr Leu Thr  Cys Val Phe Ser Gly  Gly Lys Ala 
    1445                 1450                 1455             


Val Pro  Leu Ser Ala Ser Gln  Met Pro Pro Ala Lys  Met Ser Val 
    1460                 1465                 1470             


Met Leu  Pro Ser Val Asn Leu  Glu Asp Cys Ser Gln  Ser Leu Ser 
    1475                 1480                 1485             


Leu Ser  Thr Met Gln Glu Asp  Met Glu Ser Ser Gly  Ala Asp Thr 
    1490                 1495                 1500             


Phe 
    


<210> 7476
<211> 756
<212> PRT
<213> Homo sapiens

<400> 7476
Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp 
145                 150                 155                 160 


Cys Leu Ile Arg Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu 
                165                 170                 175     


Thr Gln Asp Asp Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile 
            180                 185                 190         


Glu Asn Glu Ser Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val 
        195                 200                 205             


Leu Ala Gly His Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val 
    210                 215                 220                 


Phe Tyr Lys Asp Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala 
225                 230                 235                 240 


Ser Met Asp Lys Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly 
                245                 250                 255     


Val Trp Leu Glu Gln Val Arg Val Gly Glu Val Gly Gly Asn Thr Leu 
            260                 265                 270         


Gly Phe Tyr Asp Cys Gln Phe Asn Glu Asp Gly Ser Met Ile Ile Ala 
        275                 280                 285             


His Ala Phe His Gly Ala Leu His Leu Trp Lys Gln Asn Thr Val Asn 
    290                 295                 300                 


Pro Arg Glu Trp Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp Gly 
305                 310                 315                 320 


Val Gln Asp Leu Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr Val 
                325                 330                 335     


Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys Asp 
            340                 345                 350         


Gln Ser Gln Val Thr Trp His Glu Ile Ala Arg Pro Gln Ile His Gly 
        355                 360                 365             


Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val Ser 
    370                 375                 380                 


Gly Ala Asp Glu Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn Phe 
385                 390                 395                 400 


Val Glu Asn Phe Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val Leu 
                405                 410                 415     


Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala Leu 
            420                 425                 430         


Gly Leu Ser Asn Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln Pro 
        435                 440                 445             


Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln Gln 
    450                 455                 460                 


Val Ala Phe Gln Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp His 
465                 470                 475                 480 


Leu Leu Gln Asn Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly His 
                485                 490                 495     


Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu Leu 
            500                 505                 510         


Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile Leu 
        515                 520                 525             


Trp Asn Thr Thr Ser Trp Lys Gln Val Gln Asn Leu Val Phe His Ser 
    530                 535                 540                 


Leu Thr Val Thr Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu Leu 
545                 550                 555                 560 


Ala Val Ser Arg Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp Thr 
                565                 570                 575     


Ile Ser Pro Glu Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr Asn 
            580                 585                 590         


Lys Ile Thr Ser Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp Ser 
        595                 600                 605             


Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val Val 
    610                 615                 620                 


Val Trp Gly Glu Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn Ile 
625                 630                 635                 640 


Gly Pro Cys Ser Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala Val 
                645                 650                 655     


Ser Val Cys Pro Val Leu His Pro Ser Gln Arg Tyr Val Val Ala Val 
            660                 665                 670         


Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr Asp 
        675                 680                 685             


Gln Val Pro Glu Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser Gln 
    690                 695                 700                 


Ser Gln Ser His Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn Cys 
705                 710                 715                 720 


Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu His 
                725                 730                 735     


Phe Ala Ser Cys Gly Glu Asp His Thr Val Lys Ile His Arg Val Asn 
            740                 745                 750         


Lys Cys Ala Leu 
        755     


<210> 7477
<211> 114
<212> PRT
<213> Homo sapiens

<400> 7477
Met Gln Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile 
1               5                   10                  15      


Thr His Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp 
            20                  25                  30          


Glu Ile Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu 
        35                  40                  45              


Gln Ile Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys 
    50                  55                  60                  


Pro Glu Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu 
65                  70                  75                  80  


Val Arg Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala 
                85                  90                  95      


Val Ile Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp Gly Lys Lys 
            100                 105                 110         


Ile Leu 
        


<210> 7478
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7478
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 7479
<211> 486
<212> PRT
<213> Homo sapiens

<400> 7479
Met Thr Cys Gly Ser Tyr Cys Gly Gly Arg Ala Phe Ser Cys Ile Ser 
1               5                   10                  15      


Ala Cys Gly Pro Arg Pro Gly Arg Cys Cys Ile Thr Ala Ala Pro Tyr 
            20                  25                  30          


Arg Gly Ile Ser Cys Tyr Arg Gly Leu Thr Gly Gly Phe Gly Ser His 
        35                  40                  45              


Ser Val Cys Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe Gly 
    50                  55                  60                  


Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr Thr 
65                  70                  75                  80  


Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp 
                85                  90                  95      


Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys Ser 
            100                 105                 110         


Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu Glu 
        115                 120                 125             


Gln Gln Asn Lys Leu Leu Glu Thr Lys Leu Gln Phe Tyr Gln Asn Arg 
    130                 135                 140                 


Glu Cys Cys Gln Ser Asn Leu Glu Pro Leu Phe Glu Gly Tyr Ile Glu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg Leu 
                165                 170                 175     


Ala Ser Glu Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys Lys 
            180                 185                 190         


Lys Tyr Glu Glu Glu Val Ser Leu Arg Ala Thr Ala Glu Asn Glu Phe 
        195                 200                 205             


Val Ala Leu Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp 
    210                 215                 220                 


Leu Glu Ala Asn Val Glu Ala Leu Ile Gln Glu Ile Asp Phe Leu Arg 
225                 230                 235                 240 


Arg Leu Tyr Glu Glu Glu Ile Arg Val Leu Gln Ser His Ile Ser Asp 
                245                 250                 255     


Thr Ser Val Val Val Lys Leu Asp Asn Ser Arg Asp Leu Asn Met Asp 
            260                 265                 270         


Cys Ile Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Val Thr Arg 
        275                 280                 285             


Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met 
    290                 295                 300                 


Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu 
305                 310                 315                 320 


Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Val 
                325                 330                 335     


Glu Asn Ala Lys Cys Gln Asn Ser Lys Leu Glu Ala Ala Val Ala Gln 
            340                 345                 350         


Ser Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu 
        355                 360                 365             


Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys 
    370                 375                 380                 


Leu Ile Arg Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp 
385                 390                 395                 400 


Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu Gln Arg 
                405                 410                 415     


Leu Cys Glu Gly Val Gly Ser Val Asn Val Cys Val Ser Ser Ser Arg 
            420                 425                 430         


Gly Gly Val Val Cys Gly Asp Leu Cys Ala Ser Thr Thr Ala Pro Val 
        435                 440                 445             


Val Ser Thr Arg Val Ser Ser Val Pro Ser Asn Ser Asn Val Val Val 
    450                 455                 460                 


Gly Thr Thr Asn Ala Cys Ala Pro Ser Ala Arg Val Gly Val Cys Gly 
465                 470                 475                 480 


Gly Ser Cys Lys Arg Cys 
                485     


<210> 7480
<211> 569
<212> PRT
<213> Homo sapiens

<400> 7480
Met Ala Leu Leu Ser Glu Gly Leu Asp Glu Val Pro Ala Ala Cys Leu 
1               5                   10                  15      


Ser Pro Cys Gly Pro Pro Asn Pro Thr Glu Leu Phe Ser Glu Ser Arg 
            20                  25                  30          


Arg Leu Ala Leu Glu Glu Leu Val Ala Gly Gly Pro Glu Ala Phe Ala 
        35                  40                  45              


Ala Phe Leu Arg Arg Glu Arg Leu Ala Arg Phe Leu Asn Pro Asp Glu 
    50                  55                  60                  


Val His Ala Ile Leu Arg Ala Ala Glu Arg Pro Gly Glu Glu Gly Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Glu Asp Ser Phe Gly Ser Ser His Asp Cys 
                85                  90                  95      


Ser Ser Gly Thr Tyr Phe Pro Glu Gln Ser Asp Leu Glu Pro Pro Leu 
            100                 105                 110         


Leu Glu Leu Gly Trp Pro Ala Phe Tyr Gln Gly Ala Gly Glu Gly Gly 
        115                 120                 125             


Pro Tyr Gly Cys Lys Asp Ala Leu Arg Gln Gln Leu Arg Ser Ala Arg 
    130                 135                 140                 


Glu Val Ile Ala Val Val Met Asp Val Phe Thr Asp Ile Asp Ile Phe 
145                 150                 155                 160 


Arg Asp Leu Gln Glu Ile Cys Arg Lys Gln Gly Val Ala Val Tyr Ile 
                165                 170                 175     


Leu Leu Asp Gln Ala Leu Leu Ser Gln Phe Leu Asp Met Cys Met Asp 
            180                 185                 190         


Leu Lys Val His Pro Glu Gln Glu Lys Leu Met Thr Val Arg Thr Ile 
        195                 200                 205             


Thr Gly Asn Ile Tyr Tyr Ala Arg Ser Gly Thr Lys Ile Ile Gly Lys 
    210                 215                 220                 


Val His Glu Lys Phe Thr Leu Ile Asp Gly Ile Arg Val Ala Thr Gly 
225                 230                 235                 240 


Ser Tyr Ser Phe Thr Trp Thr Asp Gly Lys Leu Asn Ser Ser Asn Leu 
                245                 250                 255     


Val Ile Leu Ser Gly Gln Val Val Glu His Phe Asp Leu Glu Phe Arg 
            260                 265                 270         


Ile Leu Tyr Ala Gln Ser Lys Pro Ile Ser Pro Lys Leu Leu Ser His 
        275                 280                 285             


Phe Gln Ser Ser Asn Lys Phe Asp His Leu Thr Asn Arg Lys Pro Gln 
    290                 295                 300                 


Ser Lys Glu Leu Thr Leu Gly Asn Leu Leu Arg Met Arg Leu Ala Arg 
305                 310                 315                 320 


Leu Ser Ser Thr Pro Arg Lys Ala Asp Leu Asp Pro Glu Met Pro Ala 
                325                 330                 335     


Glu Gly Lys Ala Glu Arg Lys Pro His Asp Cys Glu Ser Ser Thr Val 
            340                 345                 350         


Ser Glu Glu Asp Tyr Phe Ser Ser His Arg Asp Glu Leu Gln Ser Arg 
        355                 360                 365             


Lys Ala Ile Asp Ala Ala Thr Gln Thr Glu Pro Gly Glu Glu Met Pro 
    370                 375                 380                 


Gly Leu Ser Val Ser Glu Val Gly Thr Gln Thr Ser Ile Thr Thr Ala 
385                 390                 395                 400 


Cys Ala Gly Thr Gln Thr Ala Val Ile Thr Arg Ile Ala Ser Ser Gln 
                405                 410                 415     


Thr Thr Ile Trp Ser Arg Ser Thr Thr Thr Gln Thr Asp Met Asp Glu 
            420                 425                 430         


Asn Ile Leu Phe Pro Arg Gly Thr Gln Ser Thr Glu Gly Ser Pro Val 
        435                 440                 445             


Ser Lys Met Ser Val Ser Arg Ser Ser Ser Leu Lys Ser Ser Ser Ser 
    450                 455                 460                 


Val Ser Ser Gln Gly Ser Val Ala Ser Ser Thr Gly Ser Pro Ala Ser 
465                 470                 475                 480 


Ile Arg Thr Thr Asp Phe His Asn Pro Gly Tyr Pro Lys Tyr Leu Gly 
                485                 490                 495     


Thr Pro His Leu Glu Leu Tyr Leu Ser Asp Ser Leu Arg Asn Leu Asn 
            500                 505                 510         


Lys Glu Arg Gln Phe His Phe Ala Gly Ile Arg Ser Arg Leu Asn His 
        515                 520                 525             


Met Leu Ala Met Leu Ser Arg Arg Thr Leu Phe Thr Glu Asn His Leu 
    530                 535                 540                 


Gly Leu His Ser Gly Asn Phe Ser Arg Val Asn Leu Leu Ala Val Arg 
545                 550                 555                 560 


Asp Val Ala Leu Tyr Pro Ser Tyr Gln 
                565                 


<210> 7481
<211> 407
<212> PRT
<213> Homo sapiens

<400> 7481
Met Val Leu Phe Ser Asp Ser Ser Leu Pro His Trp Gln Gln Gln Pro 
1               5                   10                  15      


Pro Gln Pro Ala Pro Pro Pro Pro Leu Phe Pro Arg Gln Gln Gln Val 
            20                  25                  30          


Gln Val Asn Lys Gly Arg Val Asn Cys His Pro Arg Cys Arg Tyr Ile 
        35                  40                  45              


Lys Thr Lys Pro Cys His Gln Leu Ser His Gln Val Trp Val Gln Gln 
    50                  55                  60                  


Lys Pro Ser His Arg Leu Leu Ser Leu Gln Leu Ser Pro Ser Pro Lys 
65                  70                  75                  80  


Pro Ser Pro Ser Pro Gln Leu Ser Leu Lys Phe Arg Leu Ser Leu Lys 
                85                  90                  95      


Phe Arg Pro Lys Gln Leu Phe His Pro Met Ser Leu Leu Lys His Asn 
            100                 105                 110         


Pro Pro Thr His Ser His Pro Ser Pro Lys Leu Gln Gln Ser Gln Pro 
        115                 120                 125             


Gln Ser Asn Val Gln Gly Gln Ser Pro Val Arg Val Gln Ser Pro Ser 
    130                 135                 140                 


Gln Thr Arg Ile Arg Pro Ser Thr Pro Ser Gln Leu Ser Pro Gly Gln 
145                 150                 155                 160 


Gln Ser Gln Val Gln Thr Thr Thr Ser Gln Pro Ile Pro Ile Gln Pro 
                165                 170                 175     


His Thr Ser Leu Gln Ile Pro Ser Gln Gly Gln Pro Gln Ser Gln Pro 
            180                 185                 190         


Gln Val Val Met Lys His Asn Ala Val Ile Glu His Leu Lys Gln Lys 
        195                 200                 205             


Lys Ser Met Thr Pro Ala Glu Arg Glu Glu Asn Gln Arg Met Ile Val 
    210                 215                 220                 


Cys Asn Gln Val Met Lys Tyr Ile Leu Asp Lys Ile Asp Lys Glu Glu 
225                 230                 235                 240 


Lys Gln Ala Ala Lys Lys Arg Lys Arg Glu Glu Ser Val Glu Gln Lys 
                245                 250                 255     


Arg Ser Lys Gln Asn Ala Thr Lys Leu Ser Ala Leu Leu Phe Lys His 
            260                 265                 270         


Lys Glu Gln Leu Arg Ala Glu Ile Leu Lys Lys Arg Ala Leu Leu Asp 
        275                 280                 285             


Lys Asp Leu Gln Ile Glu Val Gln Glu Glu Leu Lys Arg Asp Leu Lys 
    290                 295                 300                 


Ile Lys Lys Glu Lys Asp Leu Met Gln Leu Ala Gln Ala Thr Ala Val 
305                 310                 315                 320 


Ala Ala Pro Cys Pro Pro Val Thr Pro Ala Pro Pro Ala Pro Pro Ala 
                325                 330                 335     


Pro Pro Pro Ser Pro Pro Pro Pro Pro Ala Val Gln His Thr Gly Leu 
            340                 345                 350         


Leu Ser Thr Pro Thr Leu Pro Ala Ala Ser Gln Lys Arg Lys Arg Glu 
        355                 360                 365             


Glu Glu Lys Asp Ser Ser Ser Lys Ser Lys Lys Lys Lys Met Ile Ser 
    370                 375                 380                 


Thr Thr Ser Lys Glu Thr Lys Lys Asp Thr Lys Leu Tyr Cys Ile Cys 
385                 390                 395                 400 


Lys Thr Pro Tyr Asp Glu Ser 
                405         


<210> 7482
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7482
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Glu Lys Ile Leu Asn His Leu Ser Thr 
65                  70                  75                  80  


Leu Arg Arg Asp Arg Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu 
                85                  90                  95      


Ala Asp Ile Leu Ala Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr 
            100                 105                 110         


Ile Val Ala Glu Phe Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu 
        115                 120                 125             


Glu His Leu Leu Glu Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu 
    130                 135                 140                 


Gly Arg Glu Lys Phe Lys Ser Arg Gly Val Gly Glu Leu Ala Arg 
145                 150                 155                 


<210> 7483
<211> 102
<212> PRT
<213> Homo sapiens

<400> 7483
Met Asn Glu Ala Glu Ile Val Asp Val Ala Leu Gly Ile Leu Ile Glu 
1               5                   10                  15      


Ser Arg Lys Gln Glu Lys Ala Cys Glu Gln Pro Ala Leu Ala Gly Ala 
            20                  25                  30          


Asp Asn Pro Glu His Ser Pro Pro Cys Ser Val Ser Pro His Thr Ser 
        35                  40                  45              


Ser Gly Ser Ser Ser Glu Glu Glu Asp Ser Gly Lys Gln Ala Leu Ala 
    50                  55                  60                  


Pro Gly Leu Ser Pro Ser Gln Arg Pro Gly Gly Ser Ser Ser Ala Cys 
65                  70                  75                  80  


Ser Arg Ser Pro Glu Glu Glu Glu Glu Glu Asp Val Leu Lys Tyr Val 
                85                  90                  95      


Arg Glu Ile Phe Phe Ser 
            100         


<210> 7484
<211> 114
<212> PRT
<213> Homo sapiens

<400> 7484
Met Gln Phe Gly Glu Leu Leu Ala Ala Val Arg Lys Ala Gln Ala Asn 
1               5                   10                  15      


Val Met Leu Phe Leu Glu Glu Lys Glu Gln Ala Ala Leu Ser Gln Ala 
            20                  25                  30          


Asn Gly Ile Lys Ala His Leu Glu Tyr Arg Ser Ala Glu Met Glu Lys 
        35                  40                  45              


Ser Lys Gln Glu Leu Glu Thr Met Ala Ala Ile Ser Asn Thr Val Gln 
    50                  55                  60                  


Phe Leu Glu Arg Ser Met Thr Ser Glu Leu Lys Cys Leu Pro Leu Phe 
65                  70                  75                  80  


Ser Ala Asn Ile Gly Leu Pro Asn Leu Ser Pro Ala Pro Gly Asn Ser 
                85                  90                  95      


Ser Ser Asn Met Cys Met Thr Ser Arg Ser Thr Arg Thr Gln His Thr 
            100                 105                 110         


Ser Ile 
        


<210> 7485
<211> 192
<212> PRT
<213> Homo sapiens

<400> 7485
Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


<210> 7486
<211> 295
<212> PRT
<213> Homo sapiens

<400> 7486
Met Lys Gln Tyr Gly Leu Gly Pro Asn Gly Gly Ile Val Thr Ser Leu 
1               5                   10                  15      


Asn Leu Phe Ala Thr Arg Phe Asp Gln Val Met Lys Phe Ile Glu Lys 
            20                  25                  30          


Ala Gln Asn Met Ser Lys Tyr Val Leu Ile Asp Thr Pro Gly Gln Ile 
        35                  40                  45              


Glu Val Phe Thr Trp Ser Ala Ser Gly Thr Ile Ile Thr Glu Ala Leu 
    50                  55                  60                  


Ala Ser Ser Phe Pro Thr Val Val Ile Tyr Val Met Asp Thr Ser Arg 
65                  70                  75                  80  


Ser Thr Asn Pro Val Thr Phe Met Ser Asn Met Leu Tyr Ala Cys Ser 
                85                  90                  95      


Ile Leu Tyr Lys Thr Lys Leu Pro Phe Ile Val Val Met Asn Lys Thr 
            100                 105                 110         


Asp Ile Ile Asp His Ser Phe Ala Val Glu Trp Met Gln Asp Phe Glu 
        115                 120                 125             


Ala Phe Gln Asp Ala Leu Asn Gln Glu Thr Thr Tyr Val Ser Asn Leu 
    130                 135                 140                 


Thr Arg Ser Met Ser Leu Val Leu Asp Glu Phe Tyr Ser Ser Leu Arg 
145                 150                 155                 160 


Val Val Gly Val Ser Ala Val Leu Gly Thr Gly Leu Asp Glu Leu Phe 
                165                 170                 175     


Val Gln Val Thr Ser Ala Ala Glu Glu Tyr Glu Arg Glu Tyr Arg Pro 
            180                 185                 190         


Glu Tyr Glu Arg Leu Lys Lys Ser Leu Ala Asn Ala Glu Ser Gln Gln 
        195                 200                 205             


Gln Arg Glu Gln Leu Glu Arg Leu Arg Lys Asp Met Gly Ser Val Ala 
    210                 215                 220                 


Leu Asp Ala Gly Thr Ala Lys Asp Ser Leu Ser Pro Val Leu His Pro 
225                 230                 235                 240 


Ser Asp Leu Ile Leu Thr Arg Gly Thr Leu Asp Glu Glu Asp Glu Glu 
                245                 250                 255     


Ala Asp Ser Asp Thr Asp Asp Ile Asp His Arg Val Thr Glu Glu Ser 
            260                 265                 270         


His Glu Glu Pro Ala Phe Gln Asn Phe Met Gln Glu Ser Met Ala Gln 
        275                 280                 285             


Tyr Trp Lys Arg Asn Asn Lys 
    290                 295 


<210> 7487
<211> 403
<212> PRT
<213> Homo sapiens

<400> 7487
Met Pro Ser Ala Glu Ala Lys Leu Lys Lys Asn Arg Cys Ala Asn Cys 
1               5                   10                  15      


Phe Asp Cys Pro Gly Cys Met His Thr Leu Ser Thr Arg Ala Thr Ser 
            20                  25                  30          


Ile Ser Thr Gln Leu Pro Asp Asp Pro Ala Lys Thr Thr Met Lys Lys 
        35                  40                  45              


Ala Tyr Tyr Leu Ala Cys Gly Phe Cys Arg Trp Thr Ser Arg Asp Val 
    50                  55                  60                  


Gly Met Ala Asp Lys Ser Val Ala Ser Gly Gly Trp Gln Glu Pro Glu 
65                  70                  75                  80  


Asn Pro His Thr Gln Arg Met Asn Lys Leu Ile Glu Tyr Tyr Gln Gln 
                85                  90                  95      


Leu Ala Gln Lys Glu Lys Val Glu Arg Asp Arg Lys Lys Leu Ala Arg 
            100                 105                 110         


Arg Arg Asn Tyr Met Pro Leu Ala Phe Ser Asp Lys Tyr Gly Leu Gly 
        115                 120                 125             


Thr Arg Leu Gln Arg Pro Arg Ala Gly Ala Ser Ile Ser Thr Leu Ala 
    130                 135                 140                 


Gly Leu Ser Leu Lys Glu Gly Glu Asp Gln Lys Glu Ile Lys Ile Glu 
145                 150                 155                 160 


Pro Ala Gln Ala Val Asp Glu Val Glu Pro Leu Pro Glu Asp Tyr Tyr 
                165                 170                 175     


Thr Arg Pro Val Asn Leu Thr Glu Val Thr Thr Leu Gln Gln Arg Leu 
            180                 185                 190         


Leu Gln Pro Asp Phe Gln Pro Val Cys Ala Ser Gln Leu Tyr Pro Arg 
        195                 200                 205             


His Lys His Leu Leu Ile Lys Arg Ser Leu Arg Cys Arg Lys Cys Glu 
    210                 215                 220                 


His Asn Leu Ser Lys Pro Glu Phe Asn Pro Thr Ser Ile Lys Phe Lys 
225                 230                 235                 240 


Ile Gln Leu Val Ala Val Asn Tyr Ile Pro Glu Val Arg Ile Met Ser 
                245                 250                 255     


Ile Pro Asn Leu Arg Tyr Met Lys Glu Ser Gln Val Leu Leu Thr Leu 
            260                 265                 270         


Thr Asn Pro Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu 
        275                 280                 285             


Glu Gly Asp Pro Asp Asp Ile Asn Ser Thr Ala Lys Val Val Val Pro 
    290                 295                 300                 


Pro Lys Glu Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp 
305                 310                 315                 320 


Glu Leu Ala Glu Pro Gln Asp Phe Gln Asp Asp Pro Asp Ile Ile Ala 
                325                 330                 335     


Phe Arg Lys Ala Asn Lys Val Gly Ile Phe Ile Lys Val Thr Pro Gln 
            340                 345                 350         


Arg Glu Glu Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe 
        355                 360                 365             


Lys Asn Leu Ala Ala Pro Ile Arg Pro Ile Glu Glu Ser Asp Gln Gly 
    370                 375                 380                 


Thr Glu Val Ile Trp Leu Thr Gln His Val Glu Leu Ser Leu Gly Pro 
385                 390                 395                 400 


Leu Leu Pro 
            


<210> 7488
<211> 557
<212> PRT
<213> Homo sapiens

<400> 7488
Met Asp Gln Ser Arg Val Leu Leu Trp Val Lys Ala Glu Pro Phe Ile 
1               5                   10                  15      


Val Gly Ala Leu Gln Val Pro Pro Pro Ser Lys Phe Ser Leu His Tyr 
            20                  25                  30          


Leu Arg Lys Ile Ser Thr Tyr Val Gln Ile Arg Ala Thr Glu Gly Ala 
        35                  40                  45              


Tyr Pro Arg Leu Tyr Trp Ser Thr Trp Arg His Ile Ala Cys Gly Lys 
    50                  55                  60                  


Leu Gln Leu Ala Lys Asp Leu Ala Trp Leu Tyr Phe Glu Ile Phe Asp 
65                  70                  75                  80  


Ser Leu Ser Met Lys Thr Pro Glu Glu Arg Leu Glu Trp Ser Glu Val 
                85                  90                  95      


Leu Ser Asn Cys Met Ser Glu Glu Glu Val Glu Lys Gln Arg Asn Gln 
            100                 105                 110         


Leu Ser Val Asp Thr Leu Gln Phe Leu Leu Phe Leu Tyr Ile Gln Gln 
        115                 120                 125             


Leu Asn Lys Val Ser Leu Arg Thr Ser Leu Ile Gly Glu Glu Trp Pro 
    130                 135                 140                 


Ser Pro Arg Asn Lys Ser Gln Ser Pro Asp Leu Thr Glu Lys Ser Asn 
145                 150                 155                 160 


Cys His Asn Lys Asn Trp Asn Asp Tyr Ser His Gln Ala Phe Val Tyr 
                165                 170                 175     


Asp His Leu Ser Asp Leu Leu Glu Leu Leu Leu Asp Pro Lys Gln Leu 
            180                 185                 190         


Thr Ala Ser Phe His Ser Thr His Ser Ser Leu Val Ser Arg Glu Ala 
        195                 200                 205             


Val Val Ala Leu Ser Phe Leu Ile Glu Gly Thr Ile Ser Arg Ala Arg 
    210                 215                 220                 


Lys Ile Tyr Pro Leu His Glu Leu Ala Leu Trp Gln Pro Leu His Ala 
225                 230                 235                 240 


Asp Ser Gly Phe Ser Lys Ile Ser Lys Thr Phe Ser Phe Tyr Lys Leu 
                245                 250                 255     


Glu Thr Trp Leu Arg Ser Cys Leu Thr Gly Asn Pro Phe Gly Thr Ser 
            260                 265                 270         


Ala Cys Leu Lys Ser Gly Lys Lys Leu Ala Trp Ala His Gln Val Glu 
        275                 280                 285             


Gly Thr Thr Lys Arg Ala Lys Ile Ala Cys Asn Thr His Val Ala Pro 
    290                 295                 300                 


Arg Met His Arg Leu Val Val Met Ser Gln Val Tyr Lys Gln Thr Leu 
305                 310                 315                 320 


Ala Lys Ser Ser Asp Thr Leu Ala Gly Ala His Val Lys Ile His Arg 
                325                 330                 335     


Cys Asn Glu Ser Phe Ile Tyr Leu Leu Ser Pro Leu Arg Ser Val Thr 
            340                 345                 350         


Ile Glu Lys Cys Arg Asn Ser Ile Phe Val Leu Gly Pro Val Gly Thr 
        355                 360                 365             


Thr Leu His Leu His Ser Cys Asp Asn Val Lys Val Ile Ala Val Cys 
    370                 375                 380                 


His Arg Leu Ser Ile Ser Ser Thr Thr Gly Cys Ile Phe His Val Leu 
385                 390                 395                 400 


Thr Pro Thr Arg Pro Leu Ile Leu Ser Gly Asn Gln Thr Val Thr Phe 
                405                 410                 415     


Ala Pro Phe His Thr His Tyr Pro Met Leu Glu Asp His Met Ala Arg 
            420                 425                 430         


Thr Gly Leu Ala Thr Val Pro Asn Tyr Trp Asp Asn Pro Met Val Val 
        435                 440                 445             


Cys Arg Glu Asn Ser Asp Thr Arg Val Phe Gln Leu Leu Pro Pro Cys 
    450                 455                 460                 


Glu Phe Tyr Val Phe Ile Ile Pro Phe Glu Met Glu Gly Asp Thr Thr 
465                 470                 475                 480 


Glu Ile Pro Gly Gly Leu Pro Ser Val Tyr Gln Lys Ala Leu Gly Gln 
                485                 490                 495     


Arg Glu Gln Lys Ile Gln Ile Trp Gln Lys Thr Val Lys Glu Ala His 
            500                 505                 510         


Leu Thr Lys Asp Gln Arg Lys Gln Phe Gln Val Leu Val Glu Asn Lys 
        515                 520                 525             


Phe Tyr Glu Trp Leu Ile Asn Thr Gly His Arg Gln Gln Leu Asp Ser 
    530                 535                 540                 


Leu Val Pro Pro Ala Ala Gly Ser Lys Gln Ala Ala Gly 
545                 550                 555         


<210> 7489
<211> 153
<212> PRT
<213> Homo sapiens

<400> 7489
Met Ala Glu Gln Glu Gln Arg Lys Ile Pro Leu Val Pro Glu Asn Leu 
1               5                   10                  15      


Leu Lys Lys Arg Lys Ala Tyr Gln Ala Leu Lys Ala Thr Gln Ala Lys 
            20                  25                  30          


Gln Ala Leu Leu Ala Lys Lys Glu Gln Lys Lys Gly Lys Gly Leu Arg 
        35                  40                  45              


Phe Lys Arg Leu Glu Ser Phe Leu His Asp Ser Trp Arg Gln Lys Arg 
    50                  55                  60                  


Asp Lys Val Arg Leu Arg Arg Leu Glu Val Lys Pro His Ala Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Lys His Ser Leu Ala Phe Val Val Arg Ile Glu Arg Ile 
                85                  90                  95      


Asp Gly Val Ser Leu Leu Val Gln Arg Thr Ile Ala Arg Leu Arg Leu 
            100                 105                 110         


Lys Lys Ile Phe Ser Gly Val Phe Val Lys Val Thr Pro Gln Asn Leu 
        115                 120                 125             


Lys Met Leu Arg Ile Val Glu Pro Tyr Val Thr Trp Gly Glu Val Trp 
    130                 135                 140                 


Arg His Leu Leu Gly Arg Pro His Ser 
145                 150             


<210> 7490
<211> 689
<212> PRT
<213> Homo sapiens

<400> 7490
Met Ile Asp Ser Val Lys Leu Arg Arg Asp Ser Ala Ala Asp Phe Phe 
1               5                   10                  15      


Ser His Tyr Glu Tyr Leu Cys Ala Leu Gln Asn Ser Val Pro Leu Pro 
            20                  25                  30          


Ala Val Arg Ala Cys Leu Arg Glu Gly Val Leu Asp Phe Asn Ala Asp 
        35                  40                  45              


Arg Leu Arg Gly Val Asp Trp Ala Pro Leu Leu Ser Thr Leu Lys Ile 
    50                  55                  60                  


Asn Lys Asp Leu Pro Leu Val Ser Ile Lys Ser Phe Phe Gln Pro Trp 
65                  70                  75                  80  


Leu Gly Asp Thr Gly Ser Asp Met Asn Lys Phe Cys Arg Ser Arg Val 
                85                  90                  95      


Pro Ala Ile Arg Tyr Lys Asp Val Thr Phe Gln Leu Cys Lys Ala Leu 
            100                 105                 110         


Lys Gly Cys Leu Ser Ile Ser Ser Val Leu Lys Asn Leu Glu Leu Asn 
        115                 120                 125             


Gly Leu Ile Leu Arg Glu Arg Asp Leu Thr Ile Leu Ala Lys Gly Leu 
    130                 135                 140                 


Asn Lys Ser Ala Ser Leu Val His Leu Ser Leu Ala Asn Cys Pro Ile 
145                 150                 155                 160 


Gly Asp Gly Gly Leu Glu Ile Ile Cys Gln Gly Ile Lys Ser Ser Ile 
                165                 170                 175     


Thr Leu Lys Thr Val Asn Phe Thr Gly Cys Asn Leu Thr Trp Gln Gly 
            180                 185                 190         


Ala Asp His Met Ala Lys Ile Leu Lys Tyr Gln Thr Met Arg Arg His 
        195                 200                 205             


Glu Glu Thr Trp Ala Glu Ser Leu Arg Tyr Arg Arg Pro Asp Leu Asp 
    210                 215                 220                 


Cys Met Ala Gly Leu Arg Arg Ile Thr Leu Asn Cys Asn Thr Leu Ile 
225                 230                 235                 240 


Gly Asp Leu Gly Ala Cys Ala Phe Ala Asp Ser Leu Ser Glu Asp Leu 
                245                 250                 255     


Trp Leu Arg Ala Leu Asp Leu Gln Gln Cys Gly Leu Thr Asn Glu Gly 
            260                 265                 270         


Ala Lys Ala Leu Leu Glu Ala Leu Glu Thr Asn Thr Thr Leu Val Val 
        275                 280                 285             


Leu Asp Ile Arg Lys Asn Pro Leu Ile Asp His Ser Met Met Lys Ala 
    290                 295                 300                 


Val Ile Lys Lys Val Leu Gln Asn Gly Arg Ser Ala Lys Ser Glu Tyr 
305                 310                 315                 320 


Gln Trp Ile Thr Ser Pro Ser Val Lys Glu Pro Ser Lys Thr Ala Lys 
                325                 330                 335     


Gln Lys Arg Arg Thr Ile Ile Leu Gly Ser Gly His Lys Gly Lys Ala 
            340                 345                 350         


Thr Ile Arg Ile Gly Leu Ala Thr Lys Lys Pro Val Ser Ser Gly Arg 
        355                 360                 365             


Lys His Ser Leu Gly Lys Glu Tyr Tyr Ala Pro Ala Pro Leu Pro Pro 
    370                 375                 380                 


Gly Val Ser Gly Phe Leu Pro Trp Arg Thr Ala Glu Arg Ala Lys Arg 
385                 390                 395                 400 


His Arg Gly Phe Pro Leu Ile Lys Thr Arg Asp Ile Cys Asn Gln Leu 
                405                 410                 415     


Gln Gln Pro Gly Phe Pro Val Thr Val Thr Val Glu Ser Pro Ser Ser 
            420                 425                 430         


Ser Glu Val Glu Glu Val Asp Asp Ser Ser Glu Ser Val His Glu Val 
        435                 440                 445             


Pro Glu Lys Thr Ser Ile Glu Gln Glu Ala Leu Gln Glu Lys Leu Glu 
    450                 455                 460                 


Glu Cys Leu Lys Gln Leu Lys Glu Glu Arg Val Ile Arg Leu Lys Val 
465                 470                 475                 480 


Asp Lys Arg Val Ser Glu Leu Glu His Glu Asn Ala Gln Leu Arg Asn 
                485                 490                 495     


Ile Asn Phe Ser Leu Ser Glu Ala Leu His Ala Gln Ser Leu Thr Asn 
            500                 505                 510         


Met Ile Leu Asp Asp Glu Gly Val Leu Gly Ser Ile Glu Asn Ser Phe 
        515                 520                 525             


Gln Lys Phe His Ala Phe Leu Asp Leu Leu Lys Asp Ala Gly Leu Gly 
    530                 535                 540                 


Gln Leu Ala Thr Met Ala Gly Ile Asp Gln Ser Asp Phe Gln Leu Leu 
545                 550                 555                 560 


Gly His Pro Gln Met Thr Ser Thr Val Ser Asn Pro Pro Lys Glu Glu 
                565                 570                 575     


Lys Lys Ala Leu Glu Asp Glu Lys Pro Glu Pro Lys Gln Asn Ala Leu 
            580                 585                 590         


Gly Gln Met Gln Asn Ile Gln Phe Gln Lys Ile Thr Gly Asp Ala Arg 
        595                 600                 605             


Ile Pro Leu Pro Leu Asp Ser Phe Pro Val Pro Val Ser Thr Pro Glu 
    610                 615                 620                 


Gly Leu Gly Thr Ser Ser Asn Asn Leu Gly Val Pro Ala Thr Glu Gln 
625                 630                 635                 640 


Arg Gln Glu Ser Phe Glu Gly Phe Ile Ala Arg Met Cys Ser Pro Ser 
                645                 650                 655     


Pro Asp Ala Thr Ser Gly Thr Gly Ser Gln Arg Lys Glu Glu Glu Leu 
            660                 665                 670         


Ser Arg Asn Ser Arg Ser Ser Ser Glu Lys Lys Thr Lys Thr Glu Ser 
        675                 680                 685             


His 
    


<210> 7491
<211> 304
<212> PRT
<213> Homo sapiens

<400> 7491
Met Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe 
1               5                   10                  15      


Ser Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val 
            20                  25                  30          


Val Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu 
        35                  40                  45              


Asp Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu 
    50                  55                  60                  


Cys Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln 
65                  70                  75                  80  


Pro Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala 
                85                  90                  95      


Ser Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe 
            100                 105                 110         


His Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr 
        115                 120                 125             


Ile Lys Tyr Pro Lys Ala Cys Leu Gln Gly Ile Thr Phe Thr Arg Asp 
    130                 135                 140                 


Gly Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val 
145                 150                 155                 160 


Ser Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg His Phe Asp Thr 
                165                 170                 175     


Asp Thr Gln Asp Leu Thr Gly Ile Glu Trp Ala Pro Asn Gly Cys Val 
            180                 185                 190         


Leu Ala Val Trp Asp Thr Cys Leu Glu Val Arg Ile Leu Asn His Val 
        195                 200                 205             


Thr Trp Lys Met Ile Thr Glu Phe Gly His Pro Ala Ala Ile Asn Asp 
    210                 215                 220                 


Pro Lys Ile Val Val Tyr Lys Glu Ala Glu Lys Ser Pro Gln Leu Gly 
225                 230                 235                 240 


Leu Gly Cys Leu Ser Phe Pro Pro Pro Arg Ala Gly Ala Gly Pro Leu 
                245                 250                 255     


Pro Ser Ser Glu Ser Lys Tyr Glu Ile Ala Ser Val Pro Val Ser Leu 
            260                 265                 270         


Gln Thr Leu Lys Pro Val Thr Asp Arg Ala Asn Pro Lys Ile Gly Ile 
        275                 280                 285             


Gly Met Leu Ala Phe Ser Pro Asp Ser Tyr Phe Leu Ala Thr Arg Asn 
    290                 295                 300                 


<210> 7492
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7492
Met Lys Glu Val Gly Arg Pro Arg Glu Val Arg Gly Arg Pro Gly Lys 
1               5                   10                  15      


Ser Arg Ile Gln Lys Glu Leu Ala Asp Ile Thr Leu Asp Pro Pro Pro 
            20                  25                  30          


Asn Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg Ser 
        35                  40                  45              


Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe Phe 
    50                  55                  60                  


Leu Asp Ile Thr Phe Thr Pro Glu Tyr Pro Phe Lys Pro Pro Lys Val 
65                  70                  75                  80  


Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly Val 
                85                  90                  95      


Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr Ile 
            100                 105                 110         


Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn Pro 
        115                 120                 125             


Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn Arg 
    130                 135                 140                 


Ala Glu His Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala Thr 
145                 150                 155                 160 


<210> 7493
<211> 171
<212> PRT
<213> Homo sapiens

<400> 7493
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu 
                165                 170     


<210> 7494
<211> 200
<212> PRT
<213> Homo sapiens

<400> 7494
Val Leu Ile Phe Ala Cys Leu Val Pro Gly Phe Pro Ala Val Met Ser 
1               5                   10                  15      


Ser Arg Gly Pro Cys Thr Leu Glu Thr Leu Ile Asn Pro Ser Pro Ser 
            20                  25                  30          


Val Ala Asp Val Lys Ile Tyr Pro Glu Glu Ile Thr Pro Leu Leu Pro 
        35                  40                  45              


Ala Ile Ser Gly Glu Lys Ile Ala Glu Asp Gln Thr Cys Phe Phe Leu 
    50                  55                  60                  


Gln Ile Leu Leu Lys Tyr Met Val Ile Gln Ala Ala Ser Leu Glu Trp 
65                  70                  75                  80  


Lys Asn Lys Glu Asn Gln Asp Thr Gly Phe Lys Phe Leu Phe Thr Leu 
                85                  90                  95      


Phe Arg Lys Tyr Tyr Leu Pro His Leu Phe Pro Ser Phe Thr Lys Leu 
            100                 105                 110         


Thr Asn Ile Tyr Lys Pro Val Leu Asp Ile Pro His Leu Arg Pro Lys 
        115                 120                 125             


Pro Val Tyr Ile Thr Thr Thr Arg Asp Asn Glu Asn Ile Tyr Ser Thr 
    130                 135                 140                 


Lys Ile Pro Tyr Met Ala Ala Arg Val Val Phe Ile Lys Trp Ile Val 
145                 150                 155                 160 


Thr Phe Phe Leu Glu Lys Lys Tyr Leu Thr Ala Thr Gln Asn Thr Lys 
                165                 170                 175     


Asn Gly Val Asp Val Leu Pro Lys Ile Ile Gln Val Cys His Pro Ser 
            180                 185                 190         


Ser Phe Tyr Leu Leu Met Leu Val 
        195                 200 


<210> 7495
<211> 191
<212> PRT
<213> Homo sapiens

<400> 7495
Met Ser Ser Thr Leu Gly Lys Leu Ser Asn Gln Val Glu Glu Thr Leu 
1               5                   10                  15      


Pro Leu Leu Lys Lys Pro Leu Lys Arg Ala Ile Thr Thr Leu Met Ala 
            20                  25                  30          


Gly Ile Leu Arg Leu Val Val Gln Trp Pro Pro Gly Arg Leu Gln Thr 
        35                  40                  45              


Val Thr Lys Gly Val Glu Ser Leu Ile Cys Thr Asp Trp Ile Arg His 
    50                  55                  60                  


Lys Phe Thr Arg Ser Arg Ile Pro Glu Lys Val Phe Gln Ala Ser Pro 
65                  70                  75                  80  


Glu Asp His Glu Lys Tyr Gly Gly Asp Pro Gln Asn Pro His Lys Leu 
                85                  90                  95      


His Ile Val Thr Arg Ile Lys Ser Thr Arg Arg Arg Pro Tyr Trp Glu 
            100                 105                 110         


Lys Asp Ile Ile Lys Met Leu Gly Leu Glu Lys Ala His Thr Pro Gln 
        115                 120                 125             


Val His Lys Asn Ile Pro Ser Val Asn Ala Lys Leu Lys Val Val Lys 
    130                 135                 140                 


His Leu Ile Arg Ile Lys Pro Leu Lys Leu Pro Gln Gly Leu Pro Ala 
145                 150                 155                 160 


Glu Glu Asn Met Ser Asn Thr Cys Leu Lys Ser Thr Gly Glu Leu Val 
                165                 170                 175     


Val Gln Trp His Leu Lys Pro Val Glu Gln Lys Ala His Glu Ser 
            180                 185                 190     


<210> 7496
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7496
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7497
<211> 106
<212> PRT
<213> Homo sapiens

<400> 7497
Thr Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys Asn Tyr Lys Gly 
1               5                   10                  15      


Met Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu Asn Ile Gly Thr 
            20                  25                  30          


Val Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln 
        35                  40                  45              


Glu Glu Leu Gln Ser Leu Trp Asp Lys Asp Lys Thr Lys Cys Gly Asp 
    50                  55                  60                  


Leu Gly Thr Leu His Ser Ser Lys Val Ser Ala Ser Phe Arg Leu Arg 
65                  70                  75                  80  


Asp Leu Ala Ala Asp His His Arg Thr Gln Lys Trp Gln Arg Pro Asp 
                85                  90                  95      


Val Gly Thr Ala Gly Trp Leu Pro Leu Pro 
            100                 105     


<210> 7498
<211> 507
<212> PRT
<213> Homo sapiens

<400> 7498
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Thr Gln Asn Met 
145                 150                 155                 160 


Lys Met Gly Gly Leu Pro Arg Thr Thr Pro Pro Thr Gln Lys Pro Pro 
                165                 170                 175     


Ser Pro Pro Met Ser Gly Lys Gly Thr Leu Gly Arg His Ser Pro Tyr 
            180                 185                 190         


Arg Thr Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn Asp Tyr Val 
        195                 200                 205             


Pro Ser Pro Thr Arg Asn Met Ala Pro Ser Gln Gln Ser Pro Val Arg 
    210                 215                 220                 


Thr Ala Ser Val Asn Gln Arg Asn Arg Thr Tyr Ser Ser Ser Gly Ser 
225                 230                 235                 240 


Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Thr Pro Ser Pro 
            260                 265                 270         


Pro Ser Val Phe Pro Ala Pro Ala Gly Ser Ala Gly Thr Pro Pro Leu 
        275                 280                 285             


Pro Ala Thr Ser Ala Ser Ala Pro Ala Pro Leu Val Pro Ala Thr Val 
    290                 295                 300                 


Pro Ser Ser Thr Ala Pro Asp Ala Ala Ala Gly Gly Ala Gln Thr Leu 
305                 310                 315                 320 


Ala Asp Gly Phe Thr Ser Pro Thr Pro Pro Val Val Ser Ser Thr Pro 
                325                 330                 335     


Pro Thr Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser 
            340                 345                 350         


Arg His Thr Pro Pro Thr Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro 
        355                 360                 365             


Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln Asn Gln Met Asn Gly Gly 
    370                 375                 380                 


Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp Thr Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro 
                405                 410                 415     


Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp 
            420                 425                 430         


Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu 
        435                 440                 445             


Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp Lys Glu Asp Glu Leu 
    450                 455                 460                 


Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
465                 470                 475                 480 


Gly Trp Tyr Glu Gly Val Met Asn Gly Val Thr Gly Leu Phe Pro Gly 
                485                 490                 495     


Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
            500                 505         


<210> 7499
<211> 100
<212> PRT
<213> Homo sapiens

<400> 7499
Met Ala Ser Ala Gly Thr Gln His Tyr Ser Ile Gly Leu Arg Gln Lys 
1               5                   10                  15      


Asn Ser Phe Lys Gln Ser Gly Pro Ser Gly Thr Val Pro Ala Thr Pro 
            20                  25                  30          


Pro Glu Lys Pro Ser Glu Gly Arg Val Trp Pro Gln Ala His Gln Gln 
        35                  40                  45              


Val Lys Pro Ile Trp Lys Leu Glu Lys Lys Gln Val Glu Thr Leu Ser 
    50                  55                  60                  


Ala Gly Leu Gly Pro Gly Leu Leu Gly Val Pro Pro Gln Pro Ala Tyr 
65                  70                  75                  80  


Phe Phe Cys Pro Ser Thr Leu Cys Ser Ser Gly Thr Thr Ala Val Ile 
                85                  90                  95      


Ala Gly His Ser 
            100 


<210> 7500
<211> 403
<212> PRT
<213> Homo sapiens

<400> 7500
Met Ala Ser Ala Leu Arg Pro Pro Arg Val Pro Lys Pro Lys Gly Val 
1               5                   10                  15      


Leu Pro Ser His Tyr Tyr Glu Ser Phe Leu Glu Lys Lys Gly Pro Cys 
            20                  25                  30          


Asp Arg Asp Tyr Lys Lys Phe Trp Ala Gly Leu Gln Gly Leu Thr Ile 
        35                  40                  45              


Tyr Phe Tyr Asn Ser Asn Arg Asp Phe Gln His Val Glu Lys Leu Asn 
    50                  55                  60                  


Leu Gly Ala Phe Glu Lys Leu Thr Asp Glu Ile Pro Trp Gly Ser Ser 
65                  70                  75                  80  


Arg Asp Pro Gly Thr His Phe Ser Leu Ile Leu Arg Asp Gln Glu Ile 
                85                  90                  95      


Lys Phe Lys Val Glu Thr Leu Glu Cys Arg Glu Met Trp Lys Gly Phe 
            100                 105                 110         


Ile Leu Thr Val Val Glu Leu Arg Val Pro Thr Asp Leu Thr Leu Leu 
        115                 120                 125             


Pro Gly His Leu Tyr Met Met Ser Glu Val Leu Ala Lys Glu Glu Ala 
    130                 135                 140                 


Arg Arg Ala Leu Glu Thr Pro Ser Cys Phe Leu Lys Val Ser Arg Leu 
145                 150                 155                 160 


Glu Ala Gln Leu Leu Leu Glu Arg Tyr Pro Glu Cys Gly Asn Leu Leu 
                165                 170                 175     


Leu Arg Pro Ser Gly Asp Gly Ala Asp Gly Val Ser Val Thr Thr Arg 
            180                 185                 190         


Gln Met His Asn Gly Thr His Val Val Arg His Tyr Lys Val Lys Arg 
        195                 200                 205             


Glu Gly Pro Lys Tyr Val Ile Asp Val Glu Gln Pro Phe Ser Cys Thr 
    210                 215                 220                 


Ser Leu Asp Ala Val Val Asn Tyr Phe Val Ser His Thr Lys Lys Ala 
225                 230                 235                 240 


Leu Val Pro Phe Leu Leu Asp Glu Asp Tyr Glu Lys Val Leu Gly Tyr 
                245                 250                 255     


Val Glu Ala Asp Lys Glu Asn Gly Glu Asn Val Trp Val Ala Pro Ser 
            260                 265                 270         


Ala Pro Gly Pro Gly Pro Ala Pro Cys Thr Gly Gly Pro Lys Pro Leu 
        275                 280                 285             


Ser Pro Ala Ser Ser Gln Asp Lys Leu Pro Pro Leu Pro Pro Leu Pro 
    290                 295                 300                 


Asn Gln Glu Glu Asn Tyr Val Thr Pro Ile Gly Asp Gly Pro Ala Val 
305                 310                 315                 320 


Asp Tyr Glu Asn Gln Asp Val Ala Ser Ser Ser Trp Pro Val Ile Leu 
                325                 330                 335     


Lys Pro Lys Lys Leu Pro Lys Pro Pro Ala Lys Leu Pro Lys Pro Pro 
            340                 345                 350         


Val Gly Pro Lys Pro Glu Pro Lys Val Phe Asn Gly Gly Leu Gly Arg 
        355                 360                 365             


Lys Leu Pro Val Ser Ser Ala Gln Pro Leu Phe Pro Thr Ala Gly Leu 
    370                 375                 380                 


Ala Asp Met Thr Ala Glu Leu Gln Lys Lys Leu Glu Lys Arg Arg Ala 
385                 390                 395                 400 


Leu Glu His 
            


<210> 7501
<211> 516
<212> PRT
<213> Homo sapiens

<400> 7501
Met Leu Arg Arg Gly Ser Gln Ala Leu Arg Arg Phe Ser Thr Gly Arg 
1               5                   10                  15      


Val Tyr Phe Lys Asn Lys Leu Lys Leu Ala Leu Ile Gly Gln Ser Leu 
            20                  25                  30          


Phe Gly Gln Glu Val Tyr Ser His Leu Arg Lys Glu Gly His Arg Val 
        35                  40                  45              


Val Gly Val Phe Thr Val Pro Asp Lys Asp Gly Lys Ala Asp Pro Leu 
    50                  55                  60                  


Ala Leu Ala Ala Glu Lys Asp Gly Thr Pro Val Phe Lys Leu Pro Lys 
65                  70                  75                  80  


Trp Arg Val Lys Gly Lys Thr Ile Lys Glu Val Ala Glu Ala Tyr Arg 
                85                  90                  95      


Ser Val Gly Ala Glu Leu Asn Val Leu Pro Phe Cys Thr Gln Phe Ile 
            100                 105                 110         


Pro Met Asp Ile Ile Asp Ser Pro Lys His Gly Ser Ile Ile Tyr His 
        115                 120                 125             


Pro Ser Ile Leu Pro Arg His Arg Gly Ala Ser Ala Ile Asn Trp Thr 
    130                 135                 140                 


Leu Ile Met Gly Asp Lys Lys Ala Gly Phe Ser Val Phe Trp Ala Asp 
145                 150                 155                 160 


Asp Gly Leu Asp Thr Gly Pro Ile Leu Leu Gln Arg Ser Cys Asp Val 
                165                 170                 175     


Glu Pro Asn Asp Thr Val Asp Ala Leu Tyr Asn Arg Phe Leu Phe Pro 
            180                 185                 190         


Glu Gly Ile Lys Ala Met Val Glu Ala Val Gln Leu Ile Ala Asp Gly 
        195                 200                 205             


Lys Ala Pro Arg Ile Pro Gln Pro Glu Glu Gly Ala Thr Tyr Glu Gly 
    210                 215                 220                 


Ile Gln Lys Lys Glu Asn Ala Glu Ile Ser Trp Asp Gln Ser Ala Glu 
225                 230                 235                 240 


Val Leu His Asn Trp Ile Arg Gly His Asp Lys Val Pro Gly Ala Trp 
                245                 250                 255     


Thr Glu Ile Asn Gly Gln Met Val Thr Phe Tyr Gly Ser Thr Leu Leu 
            260                 265                 270         


Asn Ser Ser Val Pro Pro Gly Glu Pro Leu Glu Ile Lys Gly Ala Lys 
        275                 280                 285             


Lys Pro Gly Leu Val Thr Lys Asn Gly Leu Val Leu Phe Gly Asn Asp 
    290                 295                 300                 


Gly Lys Ala Leu Thr Val Arg Asn Leu Gln Phe Glu Asp Gly Lys Met 
305                 310                 315                 320 


Ile Pro Ala Ser Gln Tyr Phe Ser Thr Gly Glu Thr Ser Val Val Glu 
                325                 330                 335     


Leu Thr Ala Glu Glu Val Lys Val Ala Glu Thr Ile Lys Val Ile Trp 
            340                 345                 350         


Ala Gly Ile Leu Ser Asn Val Pro Ile Ile Glu Asp Ser Thr Asp Phe 
        355                 360                 365             


Phe Lys Ser Gly Ala Ser Ser Met Asp Val Ala Arg Leu Val Glu Glu 
    370                 375                 380                 


Ile Arg Gln Lys Cys Gly Gly Leu Gln Leu Gln Asn Glu Asp Val Tyr 
385                 390                 395                 400 


Met Ala Thr Lys Phe Glu Gly Phe Ile Gln Lys Val Val Arg Lys Leu 
                405                 410                 415     


Arg Gly Glu Asp Gln Glu Val Glu Leu Val Val Asp Tyr Ile Ser Lys 
            420                 425                 430         


Glu Val Asn Glu Ile Met Val Lys Met Pro Tyr Gln Cys Phe Ile Asn 
        435                 440                 445             


Gly Gln Phe Thr Asp Ala Asp Asp Gly Lys Thr Tyr Asp Thr Ile Asn 
    450                 455                 460                 


Pro Thr Asp Gly Ser Thr Ile Cys Lys Val Ser Tyr Ala Ser Leu Ala 
465                 470                 475                 480 


Asp Val Asp Lys Ala Val Ala Ala Ala Lys Asp Ala Phe Glu Asn Gly 
                485                 490                 495     


Glu Trp Gly Arg Met Asn Ala Arg Glu Arg Gly Arg Leu Met Tyr Ser 
            500                 505                 510         


Met Arg Met Asn 
        515     


<210> 7502
<211> 526
<212> PRT
<213> Homo sapiens

<400> 7502
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Phe Pro 
        35                  40                  45              


Ile Ser Lys Pro Asp Gly Ile Ser Gln Leu Glu Gln Asp Leu Gln Val 
    50                  55                  60                  


Phe Asp Leu Glu Thr Lys Thr Arg Glu Val Leu Arg Asp Asp Cys Ser 
65                  70                  75                  80  


Asp Gly Glu Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys 
                85                  90                  95      


Ile Ser Glu Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys 
            100                 105                 110         


His Asp Ile Thr Gln Val Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu 
        115                 120                 125             


Asp Arg Leu Glu Arg Leu Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu 
    130                 135                 140                 


Glu Arg Glu Phe Arg Gln Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser 
145                 150                 155                 160 


Glu Lys Asn Asn Glu Cys His Glu Pro Glu Lys Ser Phe Ser Leu Asp 
                165                 170                 175     


Ser Thr Ile Asp Ala Asp Gln Arg Val Leu Arg Ile Gln Asn Thr Asp 
            180                 185                 190         


Asp Asn Asp Lys Tyr Asp Met Ser Phe Asn Gln Asn Ser Ala Ser Gly 
        195                 200                 205             


Lys His Glu His Leu Asn Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys 
    210                 215                 220                 


Lys Glu Ser Leu Met Asp Leu Ser His Leu Asn Lys Trp Glu Ser Ile 
225                 230                 235                 240 


Pro Asn Thr Glu Lys Ser Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe 
                245                 250                 255     


His Gln Ser Ser Ala Leu Thr Arg His Gln Arg Ile His Thr Arg Glu 
            260                 265                 270         


Lys Pro Tyr Lys Cys Lys Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser 
        275                 280                 285             


Ser Leu Ser Arg His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys 
    290                 295                 300                 


Cys Glu Ala Ser Asp Lys Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser 
305                 310                 315                 320 


Pro Ser Ser Gly Ile Ile Gln His Lys Lys Ile His Thr Arg Ala Lys 
                325                 330                 335     


Ser Tyr Lys Cys Ser Ser Cys Glu Arg Val Phe Ser Arg Ser Val His 
            340                 345                 350         


Leu Thr Gln His Gln Lys Ile His Lys Glu Met Pro Cys Lys Cys Thr 
        355                 360                 365             


Val Cys Gly Ser Asp Phe Cys His Thr Ser Tyr Leu Leu Glu His Gln 
    370                 375                 380                 


Arg Val His His Glu Glu Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu 
385                 390                 395                 400 


Ala Tyr Ile Lys Gln Gln Gly Ile His Phe Arg Glu Lys Pro Tyr Thr 
                405                 410                 415     


Cys Ser Glu Cys Gly Lys Asp Phe Arg Leu Asn Ser His Leu Ile Gln 
            420                 425                 430         


His Gln Arg Ile His Thr Gly Glu Lys Ala His Glu Cys Asn Glu Cys 
        435                 440                 445             


Gly Lys Ala Phe Ser Gln Thr Ser Cys Leu Ile Gln His His Lys Met 
    450                 455                 460                 


His Arg Lys Glu Lys Ser Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe 
465                 470                 475                 480 


Ser His Ser Ser Asp Leu Ile Leu Gln Gln Glu Val Leu Thr Arg Gln 
                485                 490                 495     


Lys Ala Phe Asp Cys Asp Val Trp Glu Lys Asn Ser Ser Gln Arg Ala 
            500                 505                 510         


His Leu Val Gln His Gln Ser Ile His Thr Lys Glu Asn Ser 
        515                 520                 525     


<210> 7503
<211> 200
<212> PRT
<213> Homo sapiens

<400> 7503
Val Leu Ile Phe Ala Cys Leu Val Pro Gly Phe Pro Ala Val Met Ser 
1               5                   10                  15      


Ser Arg Gly Pro Cys Thr Leu Glu Thr Leu Ile Asn Pro Ser Pro Ser 
            20                  25                  30          


Val Ala Asp Val Lys Ile Tyr Pro Glu Glu Ile Thr Pro Leu Leu Pro 
        35                  40                  45              


Ala Ile Ser Gly Glu Lys Ile Ala Glu Asp Gln Thr Cys Phe Phe Leu 
    50                  55                  60                  


Gln Ile Leu Leu Lys Tyr Met Val Ile Gln Ala Ala Ser Leu Glu Trp 
65                  70                  75                  80  


Lys Asn Lys Glu Asn Gln Asp Thr Gly Phe Lys Phe Leu Phe Thr Leu 
                85                  90                  95      


Phe Arg Lys Tyr Tyr Leu Pro His Leu Phe Pro Ser Phe Thr Lys Leu 
            100                 105                 110         


Thr Asn Ile Tyr Lys Pro Val Leu Asp Ile Pro His Leu Arg Pro Lys 
        115                 120                 125             


Pro Val Tyr Ile Thr Thr Thr Arg Asp Asn Glu Asn Ile Tyr Ser Thr 
    130                 135                 140                 


Lys Ile Pro Tyr Met Ala Ala Arg Val Val Phe Ile Lys Trp Ile Val 
145                 150                 155                 160 


Thr Phe Phe Leu Glu Lys Lys Tyr Leu Thr Ala Thr Gln Asn Thr Lys 
                165                 170                 175     


Asn Gly Val Asp Val Leu Pro Lys Ile Ile Gln Val Cys His Pro Ser 
            180                 185                 190         


Ser Phe Tyr Leu Leu Met Leu Val 
        195                 200 


<210> 7504
<211> 179
<212> PRT
<213> Homo sapiens

<400> 7504
Asn Ile Lys Pro Gly Glu Gly Leu Gly Met Tyr Ile Lys Ser Thr Tyr 
1               5                   10                  15      


Asp Gly Leu His Val Ile Thr Gly Thr Thr Glu Asn Val Gly Trp Gln 
            20                  25                  30          


Leu Lys Asn Leu Val Lys Lys Leu Arg Glu Asn Pro Thr Gly Val Val 
        35                  40                  45              


Leu Leu Leu Lys Lys Arg Pro Thr Gly Ser Phe Asn Phe Thr Pro Ala 
    50                  55                  60                  


Pro Leu Lys Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Thr Ser Pro 
65                  70                  75                  80  


Pro Pro Ala Thr Thr Gln Ser Pro Glu Ser Thr Met Asp Thr Ser Leu 
                85                  90                  95      


Lys Lys Glu Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro 
            100                 105                 110         


Ala Val Pro Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly 
        115                 120                 125             


Gly Ser Ser Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu 
    130                 135                 140                 


Ser Pro Asn Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe Thr 
145                 150                 155                 160 


Ile Ala Asp Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Thr Asn Ile 
                165                 170                 175     


Leu Pro Thr 
            


<210> 7505
<211> 455
<212> PRT
<213> Homo sapiens

<400> 7505
Met Met Gly Ala Pro Asn Leu Ile Ala Asp Ser Met Glu Tyr Gly Leu 
1               5                   10                  15      


Ser Tyr Ser Val Ile Ser Tyr Leu Lys Lys Leu Ser Gln Gln Ala Lys 
            20                  25                  30          


Ile Glu Ser Asp Arg Val Ile Gly Ser Val Gly Lys Lys Val Val Gln 
        35                  40                  45              


Glu Thr Gly Ile Lys Val Arg Ser Arg Ser His Gly Leu Ser Met Ala 
    50                  55                  60                  


Tyr Arg Lys Asp Phe Gln Gln Leu Leu Gln Gly Ile Ser Glu Asp Val 
65                  70                  75                  80  


Pro His Arg Leu Leu Asp Leu Asn Met Lys Glu Tyr Thr Gly Phe Gln 
                85                  90                  95      


Val Ala Leu Leu Asn Lys Asp Leu Lys Pro Gln Thr Phe Arg Asn Ala 
            100                 105                 110         


Tyr Asp Ile Pro Arg Arg Asn Leu Leu Asp His Leu Thr Arg Met Arg 
        115                 120                 125             


Ser Asn Leu Leu Lys Ser Thr Arg Arg Phe Leu Lys Gly Gln Asp Glu 
    130                 135                 140                 


Asp Gln Val His Ser Val Pro Ile Ala Gln Met Gly Asn Tyr Gln Glu 
145                 150                 155                 160 


Tyr Leu Lys Gln Val Pro Ser Pro Leu Arg Glu Leu Asp Pro Asp Gln 
                165                 170                 175     


Pro Arg Arg Leu His Thr Phe Gly Asn Pro Phe Lys Leu Asp Lys Lys 
            180                 185                 190         


Gly Met Met Ile Asp Glu Ala Asp Glu Phe Val Ala Gly Pro Gln Asn 
        195                 200                 205             


Lys His Lys Arg Pro Gly Glu Pro Asn Met Gln Gly Ile Pro Lys Arg 
    210                 215                 220                 


Arg Arg Cys Met Ser Pro Leu Leu Arg Gly Arg Gln Gln Asn Pro Val 
225                 230                 235                 240 


Val Asn Asn His Ile Gly Gly Lys Gly Pro Pro Ala Pro Thr Thr Gln 
                245                 250                 255     


Ala Gln Pro Asp Leu Ile Lys Pro Leu Pro Leu His Lys Ile Ser Glu 
            260                 265                 270         


Thr Thr Asn Asp Ser Ile Ile His Asp Val Val Glu Asn His Val Ala 
        275                 280                 285             


Asp Gln Leu Ser Ser Asp Ile Thr Pro Asn Ala Met Asp Thr Glu Phe 
    290                 295                 300                 


Ser Ala Ser Ser Pro Ala Ser Leu Leu Glu Arg Pro Thr Asn His Met 
305                 310                 315                 320 


Glu Ala Leu Gly His Asp His Leu Gly Thr Asn Asp Leu Thr Val Gly 
                325                 330                 335     


Gly Phe Leu Glu Asn His Glu Glu Pro Arg Asp Lys Glu Gln Cys Ala 
            340                 345                 350         


Glu Glu Asn Ile Pro Ala Ser Ser Leu Asn Lys Gly Lys Lys Leu Met 
        355                 360                 365             


His Cys Arg Ser His Glu Glu Val Asn Thr Glu Leu Lys Ala Gln Ile 
    370                 375                 380                 


Met Lys Glu Ile Arg Lys Pro Gly Arg Lys Tyr Glu Arg Ile Phe Thr 
385                 390                 395                 400 


Leu Leu Lys His Val Gln Gly Ser Leu Gln Thr Arg Leu Ile Phe Leu 
                405                 410                 415     


Gln Asn Val Ile Lys Glu Ala Ser Arg Phe Lys Lys Arg Met Leu Ile 
            420                 425                 430         


Glu Gln Leu Glu Asn Phe Leu Asp Glu Ile His Arg Arg Ala Asn Gln 
        435                 440                 445             


Ile Asn His Ile Asn Ser Asn 
    450                 455 


<210> 7506
<211> 488
<212> PRT
<213> Homo sapiens

<400> 7506
Leu Asp Cys Gly Pro Arg Leu Pro Val Glu Val Gly Pro Ser Leu Ser 
1               5                   10                  15      


Ser Pro Ser Ser Gly Cys Gly Glu Gly Ser Ile Ser Val Gly Glu Asn 
            20                  25                  30          


Val Ser Asp Val Ala Pro Thr Gln Pro Trp Trp Pro Asn Thr Pro Gly 
        35                  40                  45              


Asp Ser Val Ser Glu Glu Leu Gly Pro Gly Arg Ser Gly Asp Thr Glu 
    50                  55                  60                  


Asp Leu Ser Pro Asn Trp Pro Leu Asn Ser Gln Glu Asp Thr Ala Ala 
65                  70                  75                  80  


Gln Ser Ser Pro Gly Arg Gly Glu Glu Ala Glu Ala Ser Ala Ala Glu 
                85                  90                  95      


Ala Gln Gly Gly Glu Gln Ala Tyr Leu Ala Gly Leu Ala Gly Gln Tyr 
            100                 105                 110         


His Leu Glu Arg Tyr Pro Asp Ser Tyr Glu Ser Met Ser Glu Pro Pro 
        115                 120                 125             


Ile Ala His Leu Leu Arg Pro Val Leu Pro Arg Ala Phe Ala Phe Pro 
    130                 135                 140                 


Val Asp Pro Gln Val Gln Ser Ala Ala Asp Glu Thr Ala Val Gln Leu 
145                 150                 155                 160 


Ser Glu Leu Leu Thr Leu Pro Val Leu Met Lys Arg Ser Ile Thr Ala 
                165                 170                 175     


Pro Leu Ala Ala His Ile Ser Leu Val Asn Lys Ala Ala Val Asp Tyr 
            180                 185                 190         


Phe Phe Val Glu Leu His Leu Glu Ala His Tyr Glu Ala Leu Arg His 
        195                 200                 205             


Phe Leu Leu Met Glu Asp Gly Glu Phe Ala Gln Ser Leu Ser Asp Leu 
    210                 215                 220                 


Leu Phe Glu Lys Leu Gly Ala Gly Gln Thr Pro Gly Glu Leu Leu Asn 
225                 230                 235                 240 


Pro Leu Val Leu Asn Ser Val Leu Ser Lys Ala Leu Gln Cys Ser Leu 
                245                 250                 255     


His Gly Asp Thr Pro His Ala Ser Asn Leu Ser Leu Ala Leu Lys Tyr 
            260                 265                 270         


Leu Pro Glu Val Phe Ala Pro Asn Ala Pro Asp Val Leu Ser Cys Leu 
        275                 280                 285             


Glu Leu Arg Tyr Lys Val Asp Trp Pro Leu Asn Ile Val Ile Thr Glu 
    290                 295                 300                 


Gly Cys Val Ser Lys Tyr Ser Gly Val Phe Ser Phe Leu Leu Gln Leu 
305                 310                 315                 320 


Lys Leu Met Met Trp Ala Leu Lys Asp Val Cys Phe His Leu Lys Arg 
                325                 330                 335     


Thr Val Pro Ser Ala Ala Ala Val Gln Ala Arg Asp Ala Ala Phe Arg 
            340                 345                 350         


Glu Gly His Pro Gly Leu His Arg Gln Pro Asp Pro Ala Arg His Leu 
        355                 360                 365             


Val Arg Val Gln Gly Gln Val Gly His Arg Gly Arg Pro Gly Gly Asp 
    370                 375                 380                 


Pro Ala Cys Ala Arg Arg Val Pro Ala Gln Gly Arg Leu Gln Ala Ala 
385                 390                 395                 400 


Pro Val Met Asn Val Ile His Ser Ile Phe Ser Leu Val Leu Lys Phe 
                405                 410                 415     


Arg Ser Gln Leu Ile Ser Gln Ala Trp Gly Pro Pro Gly Gly Pro Arg 
            420                 425                 430         


Gly Ala Glu His Pro Asn Phe Ala Leu Met Gln Gln Ser Tyr Asn Thr 
        435                 440                 445             


Phe Lys Tyr Tyr Ser His Phe Leu Phe Lys Val Val Thr Lys Leu Val 
    450                 455                 460                 


Asn Arg Gly Tyr Gln Pro His Leu Glu Asp Phe Leu Leu Arg Ile Asn 
465                 470                 475                 480 


Phe Asn Asn Tyr Tyr Gln Asp Ala 
                485             


<210> 7507
<211> 1272
<212> PRT
<213> Homo sapiens

<400> 7507
Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Ile Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp 
        115                 120                 125             


Trp Ile Ala Tyr Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ile His His Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Tyr Arg Ser Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys 
            260                 265                 270         


Asn Tyr Met Gln Arg Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln 
                325                 330                 335     


Glu Gly Glu Pro Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu 
            340                 345                 350         


Arg Arg Asp Phe Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu 
        355                 360                 365             


Ala Leu Arg Arg Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln 
    370                 375                 380                 


Glu Glu Tyr Lys Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu 
385                 390                 395                 400 


Gln Gln Lys Glu Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu 
                405                 410                 415     


Arg Glu Ala Arg Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln 
            420                 425                 430         


Glu Glu Lys Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu 
        435                 440                 445             


Glu Glu Arg Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu 
    450                 455                 460                 


Gln Glu Tyr Ile Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu 
465                 470                 475                 480 


Val Leu Gln Gln Gln Leu Leu Gln Glu Gln Ala Met Leu Leu His Asp 
                485                 490                 495     


His Arg Arg Pro His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln 
            500                 505                 510         


Gln Glu Arg Ser Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His 
        515                 520                 525             


Tyr Glu Pro Ala Asp Arg Ala Arg Glu Val Glu Asp Arg Phe Arg Lys 
    530                 535                 540                 


Thr Asn His Ser Ser Pro Glu Ala Gln Ser Lys Gln Thr Gly Arg Val 
545                 550                 555                 560 


Leu Glu Pro Pro Val Pro Ser Arg Ser Glu Ser Phe Ser Asn Gly Asn 
                565                 570                 575     


Ser Glu Ser Val His Pro Ala Leu Gln Arg Pro Ala Glu Pro Gln Val 
            580                 585                 590         


Pro Val Arg Thr Thr Ser Arg Ser Pro Val Leu Ser Arg Arg Asp Ser 
        595                 600                 605             


Pro Leu Gln Gly Ser Gly Gln Gln Asn Ser Gln Ala Gly Gln Arg Asn 
    610                 615                 620                 


Ser Thr Ser Ile Glu Pro Arg Leu Leu Trp Glu Arg Val Glu Lys Leu 
625                 630                 635                 640 


Val Pro Arg Pro Gly Ser Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly 
                645                 650                 655     


Ser Gln Pro Gly Ser His Pro Gly Ser Gln Ser Gly Ser Gly Glu Arg 
            660                 665                 670         


Phe Arg Val Arg Ser Ser Ser Lys Ser Glu Gly Ser Pro Ser Gln Arg 
        675                 680                 685             


Leu Glu Asn Ala Val Lys Lys Pro Glu Asp Lys Lys Glu Val Phe Arg 
    690                 695                 700                 


Pro Leu Lys Pro Ala Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala 
705                 710                 715                 720 


Val Glu Asp Val Arg Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser 
                725                 730                 735     


Ser Glu Glu Ser Gly Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gln 
            740                 745                 750         


Glu Gly Ala Asp Glu Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala 
        755                 760                 765             


Ser Ser Leu Asn Leu Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met 
    770                 775                 780                 


Ile Val His Asp Asp Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys 
785                 790                 795                 800 


Glu Gly Thr Leu Ile Val Arg Gln Ser Thr Val Asp Gln Lys Arg Ala 
                805                 810                 815     


Ser His His Glu Ser Asn Gly Phe Ala Gly Arg Ile His Leu Leu Pro 
            820                 825                 830         


Asp Leu Leu Gln Gln Ser His Ser Ser Ser Thr Ser Ser Thr Ser Ser 
        835                 840                 845             


Ser Pro Ser Ser Ser Gln Pro Thr Pro Thr Met Ser Pro Gln Thr Pro 
    850                 855                 860                 


Gln Asp Lys Leu Thr Ala Asn Glu Thr Gln Ser Ala Ser Ser Thr Leu 
865                 870                 875                 880 


Gln Lys His Lys Ser Ser Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg 
                885                 890                 895     


Leu Leu Gln Ile Ser Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val 
            900                 905                 910         


Gly Phe Ser Cys Asp Gly Met Arg Pro Glu Ala Ile Arg Gln Asp Pro 
        915                 920                 925             


Thr Arg Lys Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro 
    930                 935                 940                 


Gln Ser Asp Thr Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser 
945                 950                 955                 960 


Glu Ile Leu Cys Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr 
                965                 970                 975     


Glu Ser Gly Leu Met Leu Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr 
            980                 985                 990         


Pro Leu Ile Asn Arg Arg Arg Phe  Gln Gln Met Asp Val  Leu Glu Gly 
        995                 1000                 1005             


Leu Asn  Val Leu Val Thr Ile  Ser Gly Lys Lys Asp  Lys Leu Arg 
    1010                 1015                 1020             


Val Tyr  Tyr Leu Ser Trp Leu  Arg Asn Lys Ile Leu  His Asn Asp 
    1025                 1030                 1035             


Pro Glu  Val Glu Lys Lys Gln  Gly Trp Thr Thr Val  Gly Asp Leu 
    1040                 1045                 1050             


Glu Gly  Cys Val His Tyr Lys  Val Val Lys Tyr Glu  Arg Ile Lys 
    1055                 1060                 1065             


Phe Leu  Val Ile Ala Leu Lys  Ser Ser Val Glu Val  Tyr Ala Trp 
    1070                 1075                 1080             


Ala Pro  Lys Pro Tyr His Lys  Phe Met Ala Phe Lys  Ser Phe Gly 
    1085                 1090                 1095             


Glu Leu  Val His Lys Pro Leu  Leu Val Asp Leu Thr  Val Glu Glu 
    1100                 1105                 1110             


Gly Gln  Arg Leu Lys Val Ile  Tyr Gly Ser Cys Ala  Gly Phe His 
    1115                 1120                 1125             


Ala Val  Asp Val Asp Ser Gly  Ser Val Tyr Asp Ile  Tyr Leu Pro 
    1130                 1135                 1140             


Thr His  Ile Gln Cys Ser Ile  Lys Pro His Ala Ile  Ile Ile Leu 
    1145                 1150                 1155             


Pro Asn  Thr Asp Gly Met Glu  Leu Leu Val Cys Tyr  Glu Asp Glu 
    1160                 1165                 1170             


Gly Val  Tyr Val Asn Thr Tyr  Gly Arg Ile Thr Lys  Asp Val Val 
    1175                 1180                 1185             


Leu Gln  Trp Gly Glu Met Pro  Thr Ser Val Ala Tyr  Ile Arg Ser 
    1190                 1195                 1200             


Asn Gln  Thr Met Gly Trp Gly  Glu Lys Ala Ile Glu  Ile Arg Ser 
    1205                 1210                 1215             


Val Glu  Thr Gly His Leu Asp  Gly Val Phe Met His  Lys Arg Ala 
    1220                 1225                 1230             


Gln Arg  Leu Lys Phe Leu Cys  Glu Arg Asn Asp Lys  Val Phe Phe 
    1235                 1240                 1245             


Ala Ser  Val Arg Ser Gly Gly  Ser Ser Gln Val Tyr  Phe Met Thr 
    1250                 1255                 1260             


Leu Gly  Arg Thr Ser Leu Leu  Ser Trp 
    1265                 1270         


<210> 7508
<211> 120
<212> PRT
<213> Homo sapiens

<400> 7508
Ala Leu Gln Ile Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala 
1               5                   10                  15      


Leu Lys Pro Glu Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly 
            20                  25                  30          


Lys Leu Val Arg Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala 
        35                  40                  45              


Lys Ala Val Ile Glu Leu Leu Glu Lys Ser Val Gly Val Asn Leu Asp 
    50                  55                  60                  


Gly Lys Lys Ile Leu Val Val Gly Ala His Gly Ser Leu Glu Ala Ala 
65                  70                  75                  80  


Leu Gln Cys Leu Phe Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln 
                85                  90                  95      


Trp Lys Thr Arg Gln Leu Gln Ser Lys Thr Glu Ser Arg Ser Val Thr 
            100                 105                 110         


Arg Leu Glu Cys Arg Arg Val Ile 
        115                 120 


<210> 7509
<211> 621
<212> PRT
<213> Homo sapiens

<400> 7509
Met Val Ser Ile Leu Ser Ser Phe Glu Ser Arg Leu Met Lys Leu Glu 
1               5                   10                  15      


Asn Ser Ile Ile Pro Val His Lys Gln Thr Glu Asn Leu Gln Arg Leu 
            20                  25                  30          


Gln Glu Asn Val Glu Lys Thr Leu Ser Cys Leu Asp His Val Ile Ser 
        35                  40                  45              


Tyr Tyr His Val Ala Ser Asp Thr Glu Lys Ile Ile Arg Glu Gly Pro 
    50                  55                  60                  


Thr Gly Arg Leu Glu Glu Tyr Leu Gly Ser Met Ala Lys Ile Gln Lys 
65                  70                  75                  80  


Ala Val Glu Tyr Phe Gln Asp Asn Ser Pro Asp Ser Pro Glu Leu Asn 
                85                  90                  95      


Lys Val Lys Leu Leu Phe Glu Arg Gly Lys Glu Ala Leu Glu Ser Glu 
            100                 105                 110         


Phe Arg Ser Leu Met Thr Arg His Ser Lys Val Val Ser Pro Val Leu 
        115                 120                 125             


Ile Leu Asp Leu Ile Ser Gly Asp Asp Asp Leu Glu Ala Gln Glu Asp 
    130                 135                 140                 


Val Thr Leu Glu His Leu Pro Glu Ser Val Leu Gln Asp Val Ile Arg 
145                 150                 155                 160 


Ile Ser Arg Trp Leu Val Glu Tyr Gly Arg Asn Gln Asp Phe Met Asn 
                165                 170                 175     


Val Tyr Tyr Gln Ile Arg Ser Ser Gln Leu Asp Arg Ser Ile Lys Gly 
            180                 185                 190         


Leu Lys Glu His Phe His Lys Ser Ser Ser Ser Ser Gly Val Pro Tyr 
        195                 200                 205             


Ser Pro Ala Ile Pro Asn Lys Arg Lys Asp Thr Pro Thr Lys Lys Pro 
    210                 215                 220                 


Val Lys Arg Pro Gly Thr Ile Arg Lys Ala Gln Asn Leu Leu Lys Gln 
225                 230                 235                 240 


Tyr Ser Gln His Gly Leu Asp Gly Lys Lys Gly Gly Ser Asn Leu Ile 
                245                 250                 255     


Pro Leu Glu Gly Arg Asp Asp Met Leu Asp Val Glu Thr Asp Ala Tyr 
            260                 265                 270         


Ile His Cys Val Ser Ala Phe Val Lys Leu Ala Gln Ser Glu Tyr Gln 
        275                 280                 285             


Leu Leu Ala Asp Ile Ile Pro Glu His His Gln Lys Lys Thr Phe Asp 
    290                 295                 300                 


Ser Leu Ile Gln Asp Ala Leu Asp Gly Leu Met Leu Glu Gly Glu Asn 
305                 310                 315                 320 


Ile Val Ser Ala Ala Arg Lys Ala Ile Val Arg His Asp Phe Ser Thr 
                325                 330                 335     


Val Leu Thr Val Phe Pro Ile Leu Arg His Leu Lys Gln Thr Lys Pro 
            340                 345                 350         


Glu Phe Asp Gln Val Leu Gln Gly Thr Ala Ala Ser Thr Lys Asn Lys 
        355                 360                 365             


Leu Pro Gly Leu Ile Thr Ser Met Glu Thr Ile Gly Ala Lys Ala Leu 
    370                 375                 380                 


Glu Asp Phe Ala Asp Asn Ile Lys Asn Asp Pro Asp Lys Glu Tyr Asn 
385                 390                 395                 400 


Met Pro Lys Asp Gly Thr Val His Glu Leu Thr Ser Asn Ala Ile Leu 
                405                 410                 415     


Phe Leu Gln Gln Leu Leu Asp Phe Gln Glu Thr Ala Gly Ala Met Leu 
            420                 425                 430         


Ala Ser Gln Gly Lys Val Leu Gly Asn Leu Gln Leu Asn Leu Leu Ser 
        435                 440                 445             


Lys Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser Ala Ile Phe Leu His 
    450                 455                 460                 


Asn Asn Tyr Asn Tyr Ile Leu Lys Ser Leu Glu Lys Ser Glu Leu Ile 
465                 470                 475                 480 


Gln Leu Val Ala Val Thr Gln Lys Thr Ala Glu Arg Ser Tyr Arg Glu 
                485                 490                 495     


His Ile Glu Gln Gln Ile Gln Thr Tyr Gln Arg Ser Trp Leu Lys Val 
            500                 505                 510         


Thr Asp Tyr Ile Ala Glu Lys Asn Leu Pro Val Phe Gln Pro Gly Val 
        515                 520                 525             


Lys Leu Arg Asp Lys Glu Arg Gln Ile Ile Lys Glu Arg Phe Lys Gly 
    530                 535                 540                 


Phe Asn Asp Gly Leu Glu Glu Leu Cys Lys Ile Gln Lys Ala Trp Ala 
545                 550                 555                 560 


Ile Pro Asp Thr Glu Gln Arg Asp Arg Ile Arg Gln Ala Gln Lys Thr 
                565                 570                 575     


Ile Val Lys Glu Thr Tyr Gly Ala Phe Leu Gln Lys Phe Gly Ser Val 
            580                 585                 590         


Pro Phe Thr Lys Asn Pro Glu Lys Tyr Ile Lys Tyr Gly Val Glu Gln 
        595                 600                 605             


Val Gly Asp Met Ile Asp Arg Leu Phe Asp Thr Ser Ala 
    610                 615                 620     


<210> 7510
<211> 447
<212> PRT
<213> Homo sapiens

<400> 7510
Met Asp Phe Leu Leu Gly Asn Pro Phe Ser Ser Pro Val Gly Gln Arg 
1               5                   10                  15      


Ile Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Ala Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe 
    50                  55                  60                  


His Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn 
65                  70                  75                  80  


Cys Gly His Arg Phe His Val Leu Val Ala Ser Gln Asp Phe Val Glu 
                85                  90                  95      


Ser Val Leu Val Arg Thr Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile 
            100                 105                 110         


Val His Asp Lys Val Leu Asn Leu Ile Gln Thr Val Phe Asn Ser Glu 
        115                 120                 125             


Thr Gln Ser Gly Gln Asp Ser Val Gly Thr Asp Ser Ser Gln Gln Glu 
    130                 135                 140                 


Asp Ser Gly Gln His Ala Ala Pro Leu Pro Ala Pro Pro Ile Leu Ser 
145                 150                 155                 160 


Gly Asp Thr Pro Ile Ala Pro Thr Pro Glu Gln Ile Gly Lys Leu Arg 
                165                 170                 175     


Ser Glu Leu Glu Met Val Ser Gly Asn Val Arg Val Met Ser Glu Met 
            180                 185                 190         


Leu Thr Glu Leu Val Pro Thr Gln Ala Glu Pro Ala Asp Leu Glu Leu 
        195                 200                 205             


Leu Gln Glu Leu Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Val Leu 
    210                 215                 220                 


Glu Leu Ile Pro Gln Ile Ala Asn Glu Gln Leu Thr Glu Glu Leu Leu 
225                 230                 235                 240 


Ile Val Asn Asp Asn Leu Asn Asn Val Phe Leu Arg His Glu Arg Phe 
                245                 250                 255     


Glu Arg Phe Arg Thr Gly Gln Thr Thr Lys Ala Pro Ser Glu Ala Glu 
            260                 265                 270         


Pro Ala Ala Asp Leu Ile Asp Met Gly Pro Asp Pro Ala Ala Thr Gly 
        275                 280                 285             


Asn Leu Ser Ser Gln Leu Ala Gly Met Asn Leu Gly Ser Ser Ser Val 
    290                 295                 300                 


Arg Ala Gly Leu Gln Ser Leu Glu Ala Ser Gly Arg Leu Glu Asp Glu 
305                 310                 315                 320 


Phe Asp Met Phe Ala Leu Thr Arg Gly Ser Ser Leu Ala Asp Gln Arg 
                325                 330                 335     


Lys Glu Val Lys Tyr Glu Ala Pro Gln Ala Thr Asp Gly Leu Ala Gly 
            340                 345                 350         


Ala Leu Asp Ala Arg Gln Gln Ser Thr Gly Ala Ile Pro Val Thr Gln 
        355                 360                 365             


Ala Cys Leu Met Glu Asp Ile Glu Gln Trp Leu Ser Thr Asp Val Gly 
    370                 375                 380                 


Asn Asp Ala Glu Glu Pro Lys Gly Val Thr Ser Glu Glu Phe Asp Lys 
385                 390                 395                 400 


Phe Leu Glu Glu Arg Ala Lys Ala Ala Asp Arg Leu Pro Asn Leu Ser 
                405                 410                 415     


Ser Pro Ser Ala Glu Gly Pro Pro Gly Pro Pro Ser Gly Pro Ala Pro 
            420                 425                 430         


Arg Lys Lys Thr Gln Glu Lys Asp Asp Asp Met Leu Phe Ala Leu 
        435                 440                 445         


<210> 7511
<211> 700
<212> PRT
<213> Homo sapiens

<400> 7511
Met Ala Thr Met Ile Pro Pro Val Lys Leu Lys Trp Leu Glu His Leu 
1               5                   10                  15      


Asn Ser Ser Trp Ile Thr Glu Asp Ser Glu Ser Ile Ala Thr Arg Glu 
            20                  25                  30          


Gly Val Ala Val Leu Tyr Ser Lys Leu Val Ser Asn Lys Glu Val Val 
        35                  40                  45              


Pro Leu Pro Gln Gln Val Leu Cys Leu Lys Gly Pro Gln Leu Pro Asp 
    50                  55                  60                  


Phe Glu Arg Glu Ser Leu Ser Ser Asp Glu Gln Asp His Tyr Leu Asp 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Gln Leu Ala Leu Ala Lys Met Val Cys Ser Asp 
                85                  90                  95      


Ser Pro Phe Ala Gly Ala Leu Arg Lys Arg Leu Leu Val Leu Gln Arg 
            100                 105                 110         


Val Phe Tyr Ala Leu Ser Asn Lys Tyr His Asp Lys Gly Lys Val Lys 
        115                 120                 125             


Gln Gln Gln His Ser Pro Glu Ser Ser Ser Gly Ser Ala Asp Val His 
    130                 135                 140                 


Ser Val Ser Glu Arg Pro Arg Ser Ser Thr Asp Ala Leu Ile Glu Met 
145                 150                 155                 160 


Gly Val Arg Thr Gly Leu Ser Leu Leu Phe Ala Leu Leu Arg Gln Ser 
                165                 170                 175     


Trp Met Met Pro Val Ser Gly Pro Gly Leu Ser Leu Cys Asn Asp Val 
            180                 185                 190         


Ile His Thr Ala Ile Glu Val Val Ser Ser Leu Pro Pro Leu Ser Leu 
        195                 200                 205             


Ala Asn Glu Ser Lys Ile Pro Pro Met Gly Leu Asp Cys Leu Ser Gln 
    210                 215                 220                 


Val Thr Thr Phe Leu Lys Gly Val Thr Ile Pro Asn Ser Gly Ala Asp 
225                 230                 235                 240 


Thr Leu Gly Arg Arg Leu Ala Ser Glu Leu Leu Leu Gly Leu Ala Ala 
                245                 250                 255     


Gln Arg Gly Ser Leu Arg Tyr Leu Leu Glu Trp Ile Glu Met Ala Leu 
            260                 265                 270         


Gly Ala Ser Ala Val Val His Thr Met Glu Lys Gly Lys Leu Leu Ser 
        275                 280                 285             


Ser Gln Glu Gly Met Ile Ser Phe Asp Cys Phe Met Thr Ile Leu Met 
    290                 295                 300                 


Gln Met Arg Arg Ser Leu Ile Ser Glu Asn Gln Asp Ser Ala Asp Val 
305                 310                 315                 320 


Asp Pro Gln Glu His Ser Phe Thr Arg Thr Ile Asp Glu Glu Ala Glu 
                325                 330                 335     


Met Glu Glu Gln Ala Glu Arg Asp Arg Glu Glu Gly His Pro Glu Pro 
            340                 345                 350         


Glu Asp Glu Glu Glu Glu Arg Glu His Glu Val Met Thr Ala Gly Lys 
        355                 360                 365             


Ile Phe Gln Cys Phe Leu Ser Ala Arg Glu Val Ala Arg Ser Arg Asp 
    370                 375                 380                 


Arg Asp Arg Met Asn Ser Gly Ala Gly Ser Gly Ala Arg Ala Asp Asp 
385                 390                 395                 400 


Pro Pro Pro Gln Ser Gln Gln Glu Arg Arg Val Ser Thr Asp Leu Pro 
                405                 410                 415     


Glu Gly Gln Asp Val Tyr Thr Ala Ala Cys Asn Ser Val Ile His Arg 
            420                 425                 430         


Cys Ala Leu Leu Ile Leu Gly Val Ser Pro Val Ile Asp Glu Leu Gln 
        435                 440                 445             


Lys Arg Arg Glu Glu Gly Gln Leu Gln Gln Pro Ser Thr Ser Ala Ser 
    450                 455                 460                 


Glu Gly Gly Gly Leu Met Thr Arg Ser Glu Ser Leu Thr Ala Glu Ser 
465                 470                 475                 480 


Arg Leu Val His Thr Ser Pro Asn Tyr Arg Leu Ile Lys Ser Arg Ser 
                485                 490                 495     


Glu Ser Asp Leu Ser Gln Pro Glu Ser Asp Glu Glu Gly Tyr Ala Leu 
            500                 505                 510         


Ser Gly Arg Arg Asn Val Asp Leu Asp Leu Ala Ala Ser His Arg Lys 
        515                 520                 525             


Arg Gly Pro Met His Ser Gln Leu Glu Ser Leu Ser Asp Ser Trp Ala 
    530                 535                 540                 


Arg Leu Lys His Ser Arg Asp Trp Leu Cys Asn Ser Ser Tyr Ser Phe 
545                 550                 555                 560 


Glu Ser Asp Phe Asp Leu Thr Lys Ser Leu Gly Val His Thr Leu Ile 
                565                 570                 575     


Glu Asn Val Val Ser Phe Val Ser Gly Asp Val Gly Asn Ala Pro Gly 
            580                 585                 590         


Phe Lys Glu Pro Glu Glu Ser Met Ser Thr Ser Pro Gln Ala Ser Ile 
        595                 600                 605             


Ile Ala Met Glu Gln Gln Gln Leu Arg Ala Glu Leu Arg Leu Glu Ala 
    610                 615                 620                 


Leu His Gln Ile Leu Val Leu Leu Ser Gly Met Glu Glu Lys Gly Ser 
625                 630                 635                 640 


Ile Ser Leu Ala Gly Ser Arg Leu Ser Ser Gly Phe Gln Ser Ser Thr 
                645                 650                 655     


Leu Leu Thr Ser Val Arg Leu Gln Phe Leu Ala Gly Cys Phe Gly Leu 
            660                 665                 670         


Gly Thr Val Gly His Thr Gly Gly Lys Gly Glu Ser Gly Arg Leu His 
        675                 680                 685             


His Tyr Gln Asp Gly Ile Arg Ala Ala Arg Gly Tyr 
    690                 695                 700 


<210> 7512
<211> 178
<212> PRT
<213> Homo sapiens

<400> 7512
Met Ala Asp Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn Pro 
1               5                   10                  15      


Ile Ile Asp Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly Ala 
            20                  25                  30          


Lys Pro Arg Ile Met Gln Pro Gly Phe Ala Phe Gly Val Gln Gln Leu 
        35                  40                  45              


His Pro Ala Leu Ile Gln Arg Pro Phe Gly Ile Pro Ala His Tyr Val 
    50                  55                  60                  


Tyr Pro Gln Ala Phe Val Gln Pro Gly Val Val Ile Pro His Val Gln 
65                  70                  75                  80  


Pro Thr Ala Ala Ala Ala Ser Thr Thr Pro Tyr Ile Asp Tyr Thr Gly 
                85                  90                  95      


Ala Ala Tyr Ala Gln Tyr Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Tyr Asp Gln Tyr Pro Tyr Ala Ala Ser Pro Ala Ala Ala Gly 
        115                 120                 125             


Tyr Val Thr Ala Gly Gly Tyr Gly Tyr Ala Val Gln Gln Pro Ile Thr 
    130                 135                 140                 


Ala Ala Ala Pro Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Phe Gly Gln Tyr Gln Pro Gln Gln Leu Gln Thr Asp Arg 
                165                 170                 175     


Met Gln 
        


<210> 7513
<211> 192
<212> PRT
<213> Homo sapiens

<400> 7513
Met Gly Lys Gly Cys Lys Val Val Val Cys Gly Leu Leu Ser Val Gly 
1               5                   10                  15      


Lys Thr Ala Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Thr Ile Gly 
            20                  25                  30          


Met Glu Asp Cys Glu Thr Met Glu Asp Val Tyr Met Ala Ser Val Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Lys Glu Gln Leu His Leu Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Gln Glu Gly Val Glu Leu Pro Lys His Tyr Phe Ser Phe Ala Asp 
65                  70                  75                  80  


Gly Phe Val Leu Val Tyr Ser Val Asn Asn Leu Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Phe Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Ala Ile Val Val Leu Gly Asn Lys Ile Asp Leu Ser Glu Gln Arg 
        115                 120                 125             


Gln Val Asp Ala Glu Val Ala Gln Gln Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Arg Leu Trp Glu Val Thr Val Thr Asp Arg Lys Thr Leu Ile Glu Pro 
145                 150                 155                 160 


Phe Thr Leu Leu Ala Ser Lys Leu Ser Gln Pro Gln Ser Lys Ser Ser 
                165                 170                 175     


Phe Pro Leu Pro Gly Arg Lys Asn Lys Gly Asn Ser Asn Ser Glu Asn 
            180                 185                 190         


<210> 7514
<211> 184
<212> PRT
<213> Homo sapiens

<400> 7514
Met Asn Arg Ser Gln Pro Gly Leu Leu Arg Thr Asp Pro Val Pro Glu 
1               5                   10                  15      


Glu Gly Glu Asp Val Ala Ala Thr Ile Ser Ala Thr Glu Thr Leu Ser 
            20                  25                  30          


Glu Glu Glu Gln Glu Glu Leu Arg Arg Glu Leu Ala Lys Val Glu Glu 
        35                  40                  45              


Glu Ile Gln Thr Leu Ser Gln Val Leu Ala Ala Lys Glu Lys His Leu 
    50                  55                  60                  


Ala Glu Ile Lys Arg Lys Leu Gly Ile Asn Ser Leu Gln Glu Leu Lys 
65                  70                  75                  80  


Gln Asn Ile Ala Lys Gly Trp Gln Asp Val Thr Ala Thr Ser Ala Tyr 
                85                  90                  95      


Lys Lys Thr Ser Glu Thr Leu Ser Gln Ala Gly Gln Lys Ala Ser Ala 
            100                 105                 110         


Ala Phe Ser Ser Val Gly Ser Val Ile Thr Lys Lys Leu Glu Asp Val 
        115                 120                 125             


Lys Asn Ser Pro Thr Phe Lys Ser Phe Glu Glu Lys Val Glu Asn Leu 
    130                 135                 140                 


Lys Ser Lys Val Gly Gly Thr Lys Pro Ala Gly Gly Asp Phe Gly Glu 
145                 150                 155                 160 


Val Leu Asn Ser Ala Ala Asn Ala Ser Ala Thr Thr Thr Glu Pro Leu 
                165                 170                 175     


Pro Glu Lys Thr Gln Glu Ser Leu 
            180                 


<210> 7515
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7515
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7516
<211> 203
<212> PRT
<213> Homo sapiens

<400> 7516
Met Glu Pro Pro Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly Ala 
1               5                   10                  15      


Val Arg Phe Leu Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His Val 
            20                  25                  30          


Leu Asn Arg Val Pro Leu Arg Gln Leu Leu Arg Leu Gln Arg Val Ser 
        35                  40                  45              


Arg Ala Phe Arg Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg Arg 
    50                  55                  60                  


Phe Asp Ala Ala Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu Ala 
65                  70                  75                  80  


Arg Leu Leu Arg Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala Pro 
                85                  90                  95      


Cys His Glu Trp Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala Arg 
            100                 105                 110         


Asn Pro Gln Leu Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu Ser 
        115                 120                 125             


Arg Arg Ala Leu Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln Arg 
    130                 135                 140                 


Leu Ser Leu Ala His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg Gly 
145                 150                 155                 160 


Leu Ala Asp Arg Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala Cys 
                165                 170                 175     


Arg Gln Leu Lys Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg Arg Gly 
            180                 185                 190         


Ala Gly Leu Arg Ser Leu Ser Leu Ala Val Asn 
        195                 200             


<210> 7517
<211> 607
<212> PRT
<213> Homo sapiens

<400> 7517
Met Ala Arg Gly Leu Gly Lys Ala Ser Gly Phe Pro Ala Gly Pro Ser 
1               5                   10                  15      


Gly Ala Glu Leu Pro Ala Ser Gly Arg Arg Arg Gly Pro Leu Ile Ser 
            20                  25                  30          


Leu Phe Pro Ala Val Leu Ala Ser Glu Ala Ala Met Ser Tyr Pro Ala 
        35                  40                  45              


Asp Asp Tyr Glu Ser Glu Ala Ala Tyr Asp Pro Tyr Ala Tyr Pro Ser 
    50                  55                  60                  


Asp Tyr Asp Met His Thr Gly Asp Pro Lys Gln Asp Leu Ala Tyr Glu 
65                  70                  75                  80  


Arg Gln Tyr Glu Gln Gln Thr Tyr Gln Val Ile Pro Glu Val Ile Lys 
                85                  90                  95      


Asn Phe Ile Gln Tyr Phe His Lys Thr Val Ser Asp Leu Ile Asp Gln 
            100                 105                 110         


Lys Val Tyr Glu Leu Gln Ala Ser Arg Val Ser Ser Asp Val Ile Asp 
        115                 120                 125             


Gln Lys Val Tyr Glu Ile Gln Asp Ile Tyr Glu Asn Ser Trp Thr Lys 
    130                 135                 140                 


Leu Thr Glu Arg Phe Phe Lys Asn Thr Pro Trp Pro Glu Ala Glu Ala 
145                 150                 155                 160 


Ile Ala Pro Gln Val Gly Asn Asp Ala Val Phe Leu Ile Leu Tyr Lys 
                165                 170                 175     


Glu Leu Tyr Tyr Arg His Ile Tyr Ala Lys Val Ser Gly Gly Pro Ser 
            180                 185                 190         


Leu Glu Gln Arg Phe Glu Ser Tyr Tyr Asn Tyr Cys Asn Leu Phe Asn 
        195                 200                 205             


Tyr Ile Leu Asn Ala Asp Gly Pro Ala Pro Leu Glu Leu Pro Asn Gln 
    210                 215                 220                 


Trp Leu Trp Asp Ile Ile Asp Glu Phe Ile Tyr Gln Phe Gln Ser Phe 
225                 230                 235                 240 


Ser Gln Tyr Arg Cys Lys Thr Ala Lys Lys Ser Glu Glu Glu Ile Asp 
                245                 250                 255     


Phe Leu Arg Ser Asn Pro Lys Ile Trp Asn Val His Ser Val Leu Asn 
            260                 265                 270         


Val Leu His Ser Leu Val Asp Lys Ser Asn Ile Asn Arg Gln Leu Glu 
        275                 280                 285             


Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val Ala Gly Glu Tyr Gly 
    290                 295                 300                 


Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe Ser Leu Val Gly Leu 
305                 310                 315                 320 


Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr Gln Ala Ile Lys Val 
                325                 330                 335     


Leu Glu Asn Ile Glu Leu Asn Lys Lys Ser Met Tyr Ser Arg Val Pro 
            340                 345                 350         


Glu Cys Gln Val Thr Thr Tyr Tyr Tyr Val Gly Phe Ala Tyr Leu Met 
        355                 360                 365             


Met Arg Arg Tyr Gln Asp Ala Ile Arg Val Phe Ala Asn Ile Leu Leu 
    370                 375                 380                 


Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln Arg Thr Thr Tyr Lys Tyr 
385                 390                 395                 400 


Glu Met Ile Asn Lys Gln Asn Glu Gln Met His Ala Leu Leu Ala Ile 
                405                 410                 415     


Ala Leu Thr Met Tyr Pro Met Arg Ile Asp Glu Ser Ile His Leu Gln 
            420                 425                 430         


Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg Met Gln Lys Gly Asp 
        435                 440                 445             


Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr Ser Cys Pro Lys Phe Leu 
    450                 455                 460                 


Ser Pro Val Val Pro Asn Tyr Asp Asn Val His Pro Asn Tyr His Lys 
465                 470                 475                 480 


Glu Pro Phe Leu Gln Gln Leu Lys Val Phe Ser Asp Glu Val Gln Gln 
                485                 490                 495     


Gln Ala Gln Leu Ser Thr Ile Arg Ser Phe Leu Lys Leu Tyr Thr Thr 
            500                 505                 510         


Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp Leu Thr Glu Gln Glu 
        515                 520                 525             


Phe Arg Ile Gln Leu Leu Val Phe Lys His Lys Met Lys Asn Leu Val 
    530                 535                 540                 


Trp Thr Ser Gly Ile Ser Ala Leu Asp Gly Glu Phe Gln Ser Ala Ser 
545                 550                 555                 560 


Glu Val Asp Phe Tyr Ile Asp Lys Asp Met Ile His Ile Ala Asp Thr 
                565                 570                 575     


Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe Ile Arg Gln Ile His Lys 
            580                 585                 590         


Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met Gly Gln Arg Pro 
        595                 600                 605         


<210> 7518
<211> 435
<212> PRT
<213> Homo sapiens

<400> 7518
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys 
1               5                   10                  15      


Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu 
            20                  25                  30          


Asp Ile Ser Pro Gln Arg Pro Arg Pro Ile Ile Val Ile Thr Leu Ser 
        35                  40                  45              


Pro Ala Pro Ala Pro Ser Gln Arg Ala Ala Leu Gln Leu Pro Leu Ala 
    50                  55                  60                  


Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His 
65                  70                  75                  80  


Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr 
                85                  90                  95      


Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu 
            100                 105                 110         


Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg 
        115                 120                 125             


Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser 
    130                 135                 140                 


Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His 
145                 150                 155                 160 


Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn 
                165                 170                 175     


Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys 
            180                 185                 190         


Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val 
        195                 200                 205             


Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys 
    210                 215                 220                 


Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val 
225                 230                 235                 240 


Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile 
                245                 250                 255     


His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln 
            260                 265                 270         


Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys 
        275                 280                 285             


Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg 
    290                 295                 300                 


Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp 
305                 310                 315                 320 


Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe 
                325                 330                 335     


Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu 
            340                 345                 350         


Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp 
        355                 360                 365             


Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg 
    370                 375                 380                 


Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu 
385                 390                 395                 400 


Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys 
                405                 410                 415     


Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro 
            420                 425                 430         


Phe Phe Arg 
        435 


<210> 7519
<211> 1001
<212> PRT
<213> Homo sapiens

<400> 7519
Met Ala Ser Ser Pro Leu Pro Gly Pro Asn Asp Ile Leu Leu Ala Ser 
1               5                   10                  15      


Pro Ser Ser Ala Phe Gln Pro Asp Thr Leu Ser Gln Pro Arg Pro Gly 
            20                  25                  30          


His Ala Asn Leu Lys Pro Asn Gln Val Gly Gln Val Ile Leu Tyr Gly 
        35                  40                  45              


Ile Pro Ile Val Ser Leu Val Ile Asp Gly Gln Glu Arg Leu Cys Leu 
    50                  55                  60                  


Ala Gln Ile Ser Asn Thr Leu Leu Lys Asn Phe Ser Tyr Asn Glu Ile 
65                  70                  75                  80  


His Asn Arg Arg Val Ala Leu Gly Ile Thr Cys Val Gln Cys Thr Pro 
                85                  90                  95      


Val Gln Leu Glu Ile Leu Arg Arg Ala Gly Ala Met Pro Ile Ser Ser 
            100                 105                 110         


Arg Arg Cys Gly Met Ile Thr Lys Arg Glu Ala Glu Arg Leu Cys Lys 
        115                 120                 125             


Ser Phe Leu Gly Glu Asn Arg Pro Pro Lys Leu Pro Asp Asn Phe Ala 
    130                 135                 140                 


Phe Asp Val Ser His Glu Cys Ala Trp Gly Cys Arg Gly Ser Phe Ile 
145                 150                 155                 160 


Pro Ala Arg Tyr Asn Ser Ser Arg Ala Lys Cys Ile Lys Cys Ser Tyr 
                165                 170                 175     


Cys Asn Met Tyr Phe Ser Pro Asn Lys Phe Ile Phe His Ser His Arg 
            180                 185                 190         


Thr Pro Asp Ala Lys Tyr Thr Gln Pro Asp Ala Ala Asn Phe Asn Ser 
        195                 200                 205             


Trp Arg Arg His Leu Lys Leu Thr Asp Lys Ser Pro Gln Asp Glu Leu 
    210                 215                 220                 


Val Phe Ala Trp Glu Asp Val Lys Ala Met Phe Asn Gly Gly Ser Arg 
225                 230                 235                 240 


Lys Arg Ala Leu Pro Gln Pro Gly Ala His Pro Ala Cys His Pro Leu 
                245                 250                 255     


Ser Ser Val Lys Ala Ala Ala Val Ala Ala Ala Ala Ala Val Ala Gly 
            260                 265                 270         


Gly Gly Gly Leu Leu Gly Pro His Leu Leu Gly Ala Pro Pro Pro Pro 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Leu Ala Glu Leu Ala Gly Ala Pro His Ala 
    290                 295                 300                 


His His Lys Arg Pro Arg Phe Asp Asp Asp Asp Asp Ser Leu Gln Glu 
305                 310                 315                 320 


Ala Ala Val Val Ala Ala Ala Ser Leu Ser Ala Ala Ala Ala Ser Leu 
                325                 330                 335     


Ser Val Ala Ala Ala Ser Gly Gly Ala Gly Thr Gly Gly Gly Gly Ala 
            340                 345                 350         


Gly Gly Gly Cys Val Ala Gly Val Gly Val Gly Ala Gly Ala Gly Ala 
        355                 360                 365             


Gly Ala Gly Ala Gly Ala Lys Gly Pro Arg Ser Tyr Pro Val Ile Pro 
    370                 375                 380                 


Val Pro Ser Lys Gly Ser Phe Gly Gly Val Leu Gln Lys Phe Pro Gly 
385                 390                 395                 400 


Cys Gly Gly Leu Phe Pro His Pro Tyr Thr Phe Pro Ala Ala Ala Ala 
                405                 410                 415     


Ala Phe Ser Leu Cys His Lys Lys Glu Asp Ala Gly Ala Ala Ala Glu 
            420                 425                 430         


Ala Leu Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala Ala Pro Lys Ala 
        435                 440                 445             


Gly Leu Ser Gly Leu Phe Trp Pro Ala Gly Arg Lys Asp Ala Phe Tyr 
    450                 455                 460                 


Pro Pro Phe Cys Met Phe Trp Pro Pro Arg Thr Pro Gly Gly Leu Pro 
465                 470                 475                 480 


Val Pro Thr Tyr Leu Gln Pro Pro Pro Gln Pro Pro Ser Ala Leu Gly 
                485                 490                 495     


Cys Ala Leu Gly Glu Ser Pro Ala Leu Leu Arg Gln Ala Phe Leu Asp 
            500                 505                 510         


Leu Ala Glu Pro Gly Gly Ala Ala Gly Ser Ala Glu Ala Ala Pro Pro 
        515                 520                 525             


Pro Gly Gln Pro Pro Gln Val Val Ala Asn Gly Pro Gly Ser Gly Pro 
    530                 535                 540                 


Pro Pro Pro Ala Gly Gly Ala Gly Ser Arg Asp Ala Leu Phe Glu Ser 
545                 550                 555                 560 


Pro Pro Gly Gly Ser Gly Gly Asp Cys Ser Ala Gly Ser Thr Pro Pro 
                565                 570                 575     


Ala Asp Ser Val Ala Ala Ala Gly Ala Gly Ala Ala Ala Ala Gly Ser 
            580                 585                 590         


Gly Pro Ala Gly Ser Arg Val Pro Ala Pro His His Pro His Leu Leu 
        595                 600                 605             


Glu Gly Arg Lys Ala Gly Gly Gly Ser Tyr His His Ser Ser Ala Phe 
    610                 615                 620                 


Arg Pro Val Gly Gly Lys Asp Asp Ala Glu Ser Leu Ala Lys Leu His 
625                 630                 635                 640 


Gly Ala Ser Ala Gly Ala Pro His Ser Ala Gln Thr His Pro His His 
                645                 650                 655     


His His His Pro His His His His His His His His Pro Pro Gln Pro 
            660                 665                 670         


Pro Ser Pro Leu Leu Leu Leu Pro Pro Gln Pro Asp Glu Pro Gly Ser 
        675                 680                 685             


Glu Arg His His Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    690                 695                 700                 


Pro Pro Leu Ala Gln His Pro His His Arg Gly Leu Leu Ser Pro Gly 
705                 710                 715                 720 


Gly Thr Ser Cys Cys Tyr Pro Ser Glu Asp Ser Ser Glu Asp Glu Asp 
                725                 730                 735     


Asp Glu Glu Glu Glu Gln Glu Val Asp Val Glu Gly His Lys Pro Pro 
            740                 745                 750         


Glu Gly Glu Glu Glu Glu Glu Gly Arg Asp Pro Asp Asp Asp Glu Glu 
        755                 760                 765             


Glu Asp Glu Glu Thr Glu Val Leu Leu Gly Asp Pro Leu Val Gly Gly 
    770                 775                 780                 


Gly Arg Phe Leu Gln Gly Arg Gly Pro Ser Glu Lys Gly Ser Ser Arg 
785                 790                 795                 800 


Asp Arg Ala Pro Ala Val Ala Gly Ala Phe Pro Leu Gly Leu Asn Ser 
                805                 810                 815     


Ser Arg Leu Leu Gln Glu Asp Gly Lys Leu Gly Asp Pro Gly Ser Asp 
            820                 825                 830         


Leu Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Gln Lys Ala Ser Gly 
        835                 840                 845             


Gly Gly Ser Ser Ser Pro Gly Ser Pro Val His His Pro Ser Leu Glu 
    850                 855                 860                 


Glu Gln Pro Ser Tyr Lys Asp Ser Gln Lys Thr Lys Glu Asn Asn Gln 
865                 870                 875                 880 


Val Ile Val Ser Thr Lys Asp Asp Asn Ser Phe Ser Asp Lys Asn Lys 
                885                 890                 895     


Glu His Ser Phe Phe Ile Thr Asp Ser Asp Ala Ser Gly Gly Asp Phe 
            900                 905                 910         


Trp Arg Glu Arg Ser Gly Glu His Thr Gln Glu Thr Asn Ser Pro His 
        915                 920                 925             


Ser Leu Lys Lys Asp Val Glu Asn Met Gly Lys Glu Glu Leu Gln Lys 
    930                 935                 940                 


Val Leu Phe Glu Gln Ile Asp Leu Arg Arg Arg Leu Glu Gln Glu Phe 
945                 950                 955                 960 


Gln Val Leu Lys Gly Asn Thr Ser Phe Pro Val Phe Asn Asn Phe Gln 
                965                 970                 975     


Asp Gln Met Lys Arg Glu Leu Ala Tyr Arg Glu Glu Met Val Gln Gln 
            980                 985                 990         


Leu Gln Ile Val Ser Cys Ile Ser  Thr 
        995                 1000     


<210> 7520
<211> 65
<212> PRT
<213> Homo sapiens

<400> 7520
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu 
65  


<210> 7521
<211> 346
<212> PRT
<213> Homo sapiens

<400> 7521
Met Ile Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu Met Gly Ala Asn 
1               5                   10                  15      


Glu His Gly Val Cys Ile Ala Asn Glu Ala Ile Asn Thr Arg Glu Pro 
            20                  25                  30          


Ala Ala Glu Ile Glu Ala Leu Leu Gly Met Asp Leu Val Arg Leu Gly 
        35                  40                  45              


Leu Glu Arg Gly Glu Thr Ala Lys Glu Ala Leu Asp Val Ile Val Ser 
    50                  55                  60                  


Leu Leu Glu Glu His Gly Gln Gly Gly Asn Tyr Phe Glu Asp Ala Asn 
65                  70                  75                  80  


Ser Cys His Ser Phe Gln Ser Ala Tyr Leu Ile Val Asp Arg Asp Glu 
                85                  90                  95      


Ala Trp Val Leu Glu Thr Ile Gly Lys Tyr Trp Ala Ala Glu Lys Val 
            100                 105                 110         


Thr Glu Gly Val Arg Cys Ile Cys Ser Gln Leu Ser Leu Thr Thr Lys 
        115                 120                 125             


Met Asp Ala Glu His Pro Glu Leu Arg Ser Tyr Ala Gln Ser Gln Gly 
    130                 135                 140                 


Trp Trp Thr Gly Glu Gly Glu Phe Asn Phe Ser Glu Val Phe Ser Pro 
145                 150                 155                 160 


Val Glu Asp His Leu Asp Cys Gly Ala Gly Lys Asp Ser Leu Glu Lys 
                165                 170                 175     


Gln Glu Glu Ser Ile Thr Val Gln Thr Met Met Asn Thr Leu Arg Asp 
            180                 185                 190         


Lys Ala Ser Gly Val Cys Ile Asp Ser Glu Phe Phe Leu Thr Thr Ala 
        195                 200                 205             


Ser Gly Val Ser Val Leu Pro Gln Asn Arg Ser Ser Pro Cys Ile His 
    210                 215                 220                 


Tyr Phe Thr Gly Thr Pro Asp Pro Ser Arg Ser Ile Phe Lys Pro Phe 
225                 230                 235                 240 


Ile Phe Val Asp Asp Val Lys Leu Val Pro Lys Thr Gln Ser Pro Cys 
                245                 250                 255     


Phe Gly Asp Asp Asp Pro Ala Lys Lys Glu Pro Arg Phe Gln Glu Lys 
            260                 265                 270         


Pro Asp Arg Arg His Glu Leu Tyr Lys Ala His Glu Trp Ala Arg Ala 
        275                 280                 285             


Ile Ile Glu Ser Asp Gln Glu Gln Gly Arg Lys Leu Arg Ser Thr Met 
    290                 295                 300                 


Leu Glu Leu Glu Lys Gln Gly Leu Glu Ala Met Glu Glu Ile Leu Thr 
305                 310                 315                 320 


Ser Ser Glu Pro Leu Asp Pro Ala Glu Val Gly Asp Leu Phe Tyr Asp 
                325                 330                 335     


Cys Val Asp Thr Glu Ile Lys Phe Phe Lys 
            340                 345     


<210> 7522
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7522
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7523
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7523
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7524
<211> 579
<212> PRT
<213> Homo sapiens

<400> 7524
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser 
                165                 170                 175     


Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser 
            180                 185                 190         


Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe 
        195                 200                 205             


Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys 
    210                 215                 220                 


Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg 
225                 230                 235                 240 


Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val 
                245                 250                 255     


Asp Val Gln Lys Ile Val Gly Ser Gln Ile His Phe His Gly Lys Lys 
            260                 265                 270         


Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His 
        275                 280                 285             


Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe 
    290                 295                 300                 


Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln 
305                 310                 315                 320 


Ile Thr Pro Asn Pro Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr 
                325                 330                 335     


Pro His Ser Pro Gly Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr 
            340                 345                 350         


Asn Tyr Gln Glu Tyr Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr 
        355                 360                 365             


Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr 
    370                 375                 380                 


Pro Arg Ser Pro Phe Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr 
385                 390                 395                 400 


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala 
                405                 410                 415     


Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr 
            420                 425                 430         


Pro Ser Ser Pro Phe Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr 
        435                 440                 445             


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala 
    450                 455                 460                 


Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr 
465                 470                 475                 480 


Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr 
                485                 490                 495     


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr 
            500                 505                 510         


Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr 
        515                 520                 525             


Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe His Val Tyr 
    530                 535                 540                 


Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln Arg Arg Asn 
545                 550                 555                 560 


Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys Leu Ile Gln 
                565                 570                 575     


Arg Arg Asp 
            


<210> 7525
<211> 276
<212> PRT
<213> Homo sapiens

<400> 7525
Met Tyr Ala Ser Trp Thr Lys Ala Cys Arg Gly Leu Glu Glu Leu Ile 
1               5                   10                  15      


Asn Leu Thr Arg Leu Asn Val Ser Tyr Asn His Ile Asp Asp Leu Ser 
            20                  25                  30          


Gly Leu Ile Pro Leu His Gly Ile Lys His Lys Leu Arg Tyr Ile Asp 
        35                  40                  45              


Leu His Ser Asn Arg Ile Asp Ser Ile His His Leu Leu Gln Cys Met 
    50                  55                  60                  


Val Gly Leu His Phe Leu Thr Asn Leu Ile Leu Glu Lys Asp Gly Asp 
65                  70                  75                  80  


Asp Asn Pro Val Cys Arg Leu Pro Gly Tyr Arg Ala Val Ile Leu Gln 
                85                  90                  95      


Thr Leu Pro Gln Leu Arg Ile Leu Asp Cys Lys Asn Ile Phe Gly Glu 
            100                 105                 110         


Pro Val Asn Leu Thr Glu Ile Asn Ser Ser Gln Leu Gln Cys Leu Glu 
        115                 120                 125             


Gly Leu Leu Asp Asn Leu Val Ser Ser Asp Ser Pro Leu Asn Ile Ser 
    130                 135                 140                 


Glu Asp Glu Ile Ile Asp Arg Met Pro Val Ile Thr Ala Pro Ile Asp 
145                 150                 155                 160 


Glu Leu Val Pro Leu Glu Gln Phe Ala Ser Thr Pro Ser Asp Ala Val 
                165                 170                 175     


Leu Thr Ser Phe Met Ser Val Cys Gln Ser Ser Glu Pro Glu Lys Asn 
            180                 185                 190         


Asn His Glu Asn Asp Leu Gln Asn Glu Ile Lys Leu Gln Lys Leu Asp 
        195                 200                 205             


Asp Gln Ile Leu Gln Leu Leu Asn Glu Thr Ser Asn Ser Ile Asp Asn 
    210                 215                 220                 


Val Leu Glu Lys Asp Pro Arg Pro Lys Arg Asp Thr Asp Ile Thr Ser 
225                 230                 235                 240 


Glu Ser Asp Tyr Gly Asn Ser Arg Lys Asn Gly Glu Thr Lys Lys Ala 
                245                 250                 255     


Ala Ala Gly Ser Thr Asp Lys Thr Asp Pro Arg Gly Gly Thr Gln Ser 
            260                 265                 270         


Phe Ser Cys Arg 
        275     


<210> 7526
<211> 664
<212> PRT
<213> Homo sapiens

<400> 7526
Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met Ile Thr Asp Ile 
1               5                   10                  15      


His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr Val Lys Lys Glu 
            20                  25                  30          


His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr Asp Gly Glu His 
        35                  40                  45              


Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu His Leu Asn Pro 
    50                  55                  60                  


Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser Ser Gln Ser Ser 
65                  70                  75                  80  


Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser Gln Glu Ser Met 
                85                  90                  95      


Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln Val Leu Pro Gly 
            100                 105                 110         


Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu Thr Gln Thr Val 
        115                 120                 125             


Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly Gly Glu Lys Arg 
    130                 135                 140                 


Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg Glu Phe Thr Leu 
145                 150                 155                 160 


Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile Tyr Cys Ser Arg 
                165                 170                 175     


Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu Gly Ile Leu Pro 
            180                 185                 190         


Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr Asp Ala Gln Arg 
        195                 200                 205             


Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro Gln Asn Gly Ser 
    210                 215                 220                 


Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys Glu Thr Gly Ser 
225                 230                 235                 240 


Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys Gln Gly Leu Phe 
                245                 250                 255     


Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys Ile Gln Cys Leu 
            260                 265                 270         


Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val Met His Ser His 
        275                 280                 285             


Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe Glu Ser Ala Lys 
    290                 295                 300                 


Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu Gly Thr Pro Glu 
305                 310                 315                 320 


Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys Glu Lys Phe Ser 
                325                 330                 335     


Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp Ala Pro Ser Gly 
            340                 345                 350         


Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln Glu Gly Asp His 
        355                 360                 365             


Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr Tyr Leu Tyr Met 
    370                 375                 380                 


Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr Ser Ala Val Ser 
385                 390                 395                 400 


Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Ser Lys Ser Ile Ser Arg 
                405                 410                 415     


Gln Ser Glu Lys Ala His Ser Ser Gly Lys Leu Gln Lys Thr Val Ser 
            420                 425                 430         


Tyr Pro Asp Val Ser Leu Glu Glu Gln Glu Lys Met Asp Leu Lys Thr 
        435                 440                 445             


Ser Arg Glu Leu Cys Ser Arg Leu Asp Ala Ser Ile Ser Asn Asn Ser 
    450                 455                 460                 


Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr Cys Asn Leu Val Arg Asp 
465                 470                 475                 480 


Ile Asn Lys Val Gly Ile Gly Leu Val Ala Ala Ala Ser Ser Pro Leu 
                485                 490                 495     


Leu Val Lys Asp Val Ile Cys Glu Asp Asp Lys Gly Lys Ile Met Glu 
            500                 505                 510         


Glu Val Met Arg Thr Tyr Leu Lys Gln Gln Glu Lys Leu Asn Leu Ile 
        515                 520                 525             


Leu Gln Lys Lys Gln Gln Leu Gln Met Glu Val Lys Met Leu Ser Ser 
    530                 535                 540                 


Ser Lys Ser Met Lys Glu Leu Thr Glu Glu Gln Gln Asn Leu Gln Lys 
545                 550                 555                 560 


Glu Leu Glu Ser Leu Gln Asn Glu His Ala Gln Arg Met Glu Glu Phe 
                565                 570                 575     


Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys Leu Glu Gln Ile Met Lys 
            580                 585                 590         


Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu Lys Asp Lys Glu Ala Glu 
        595                 600                 605             


Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln Arg Leu Asp His Ala Glu 
    610                 615                 620                 


Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu Arg Gln Glu Arg Glu Ala 
625                 630                 635                 640 


Arg Gln Lys Leu Glu Met Met Ile Lys Glu Leu Lys Leu Gln Ile Leu 
                645                 650                 655     


Lys Ser Ser Lys Thr Ala Lys Glu 
            660                 


<210> 7527
<211> 355
<212> PRT
<213> Homo sapiens

<400> 7527
Met Gly Arg Arg Asp Leu Val Ser Gly Gly Ser Asn Glu Gly Asn Gly 
1               5                   10                  15      


Lys Glu Asp Trp Ala Met Lys Thr Val Ser Leu Arg Trp Thr Lys Leu 
            20                  25                  30          


Pro Pro Val Lys Ser Ala Ile Arg Gly Gln Ala Pro Val Val Pro Tyr 
        35                  40                  45              


Met Arg Tyr Gly His Ser Thr Val Leu Ile Asp Asp Thr Val Leu Leu 
    50                  55                  60                  


Trp Gly Gly Arg Asn Asp Thr Glu Gly Ala Cys Asn Val Leu Tyr Ala 
65                  70                  75                  80  


Phe Asp Val Asn Thr His Lys Trp Phe Thr Pro Arg Val Ser Gly Thr 
                85                  90                  95      


Val Pro Gly Ala Arg Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile 
            100                 105                 110         


Met Tyr Ile Phe Gly Gly Tyr Glu Gln Gln Ala Asp Cys Phe Ser Asn 
        115                 120                 125             


Asp Ile His Lys Leu Asp Thr Ser Thr Met Thr Trp Thr Leu Ile Cys 
    130                 135                 140                 


Thr Lys Gly Ser Pro Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met 
145                 150                 155                 160 


Leu Gly Ser His Met Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly 
                165                 170                 175     


Pro Phe His Ser Asn Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe 
            180                 185                 190         


Asp Thr Arg Thr Glu Ala Trp Leu Asp Cys Pro Pro Thr Pro Val Leu 
        195                 200                 205             


Pro Glu Gly Arg Arg Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu 
    210                 215                 220                 


Tyr Ile Phe Gly Gly Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp 
225                 230                 235                 240 


Leu Trp Lys Phe Asn Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro 
                245                 250                 255     


Lys Gly Lys Gly Pro Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val 
            260                 265                 270         


Gly Asp Lys Ile Val Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu 
        275                 280                 285             


Gly Leu Gly Asp Glu Phe Asp Leu Ile Asp His Ser Asp Leu His Ile 
    290                 295                 300                 


Leu Asp Phe Ser Pro Ser Leu Lys Thr Leu Cys Lys Leu Ala Val Ile 
305                 310                 315                 320 


Gln Tyr Asn Leu Asp Gln Ser Cys Leu Pro His Asp Ile Arg Trp Glu 
                325                 330                 335     


Leu Asn Ala Met Thr Thr Asn Ser Asn Ile Ser Arg Pro Ile Val Ser 
            340                 345                 350         


Ser His Gly 
        355 


<210> 7528
<211> 414
<212> PRT
<213> Homo sapiens

<400> 7528
Met Ala Ala Ala Pro Pro Ser Tyr Cys Phe Val Ala Phe Pro Pro Arg 
1               5                   10                  15      


Ala Lys Asp Gly Leu Val Val Phe Gly Lys Asn Ser Ala Arg Pro Arg 
            20                  25                  30          


Asp Glu Val Gln Glu Val Val Tyr Phe Ser Ala Ala Asp His Glu Pro 
        35                  40                  45              


Glu Ser Lys Val Glu Cys Thr Tyr Ile Ser Ile Asp Gln Val Pro Arg 
    50                  55                  60                  


Thr Tyr Ala Ile Met Ile Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Ala Asn Glu Ala Ile Asn 
                85                  90                  95      


Thr Arg Glu Pro Ala Ala Glu Ile Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Gly Glu Thr Ala Lys Glu Ala Leu Asp 
        115                 120                 125             


Val Ile Val Ser Leu Leu Glu Glu His Gly Gln Gly Gly Asn Tyr Phe 
    130                 135                 140                 


Glu Asp Ala Asn Ser Cys His Ser Phe Gln Ser Ala Tyr Leu Ile Val 
145                 150                 155                 160 


Asp Arg Asp Glu Ala Trp Val Leu Glu Thr Ile Gly Lys Tyr Trp Ala 
                165                 170                 175     


Ala Glu Lys Val Thr Glu Gly Val Arg Cys Ile Cys Ser Gln Leu Ser 
            180                 185                 190         


Leu Thr Thr Lys Met Asp Ala Glu His Pro Glu Leu Arg Ser Tyr Ala 
        195                 200                 205             


Gln Ser Gln Gly Trp Trp Thr Gly Glu Gly Glu Phe Asn Phe Ser Glu 
    210                 215                 220                 


Val Phe Ser Pro Val Glu Asp His Leu Asp Cys Gly Ala Gly Lys Asp 
225                 230                 235                 240 


Ser Leu Glu Lys Gln Glu Glu Ser Ile Thr Val Gln Thr Met Met Asn 
                245                 250                 255     


Thr Leu Arg Asp Lys Ala Ser Gly Val Cys Ile Asp Ser Glu Phe Phe 
            260                 265                 270         


Leu Thr Thr Ala Ser Gly Val Ser Val Leu Pro Gln Asn Arg Ser Ser 
        275                 280                 285             


Pro Cys Ile His Tyr Phe Thr Gly Thr Pro Asp Pro Ser Arg Ser Ile 
    290                 295                 300                 


Phe Lys Pro Phe Ile Phe Val Asp Asp Val Lys Leu Val Pro Lys Thr 
305                 310                 315                 320 


Gln Ser Pro Cys Phe Gly Asp Asp Asp Pro Ala Lys Lys Glu Pro Arg 
                325                 330                 335     


Phe Gln Glu Lys Pro Asp Arg Arg His Glu Leu Tyr Lys Ala His Glu 
            340                 345                 350         


Trp Ala Arg Ala Ile Ile Glu Ser Asp Gln Glu Gln Gly Arg Lys Leu 
        355                 360                 365             


Arg Ser Thr Met Leu Glu Leu Glu Lys Gln Gly Leu Glu Ala Met Glu 
    370                 375                 380                 


Glu Ile Leu Thr Ser Ser Glu Pro Leu Asp Pro Ala Glu Val Gly Asp 
385                 390                 395                 400 


Leu Phe Tyr Asp Cys Val Asp Thr Glu Ile Lys Phe Phe Lys 
                405                 410                 


<210> 7529
<211> 399
<212> PRT
<213> Homo sapiens

<400> 7529
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


Leu Asn Cys Val Met Lys Lys His Lys Glu Leu Ser Ser Leu Gln Lys 
        115                 120                 125             


Ile Pro Ser Gln Gln Arg Lys Lys Ile Ser Ser Gly Lys Ser Glu Pro 
    130                 135                 140                 


Pro Leu Gly Asn Glu Lys Ile Ser Ala Glu Ala Val Gly Val Asp Ile 
145                 150                 155                 160 


Ser Gly Arg Phe Met Thr Ser Gly Lys Lys Lys Ala Val Val Ile Arg 
                165                 170                 175     


His Leu Tyr Asn Glu Asp Asn Val Asp Ile Ser Glu Asp Thr Leu Ser 
            180                 185                 190         


Pro Ile Thr Asp Val Asn Glu Ala Val Asp Val Ser Asp Leu Asn Ala 
        195                 200                 205             


Thr Glu Ile Lys Met Pro Glu Val Lys Val Pro Glu Ile Lys Ala Glu 
    210                 215                 220                 


Gln Gln Asp Val Asn Val Asn Pro Glu Ile Thr Ala Leu Gln Thr Met 
225                 230                 235                 240 


Leu Ala Glu Cys Gln Glu Asn Leu Lys Lys Leu Thr Ser Ile Glu Lys 
                245                 250                 255     


Arg Leu Asp Cys Leu Glu Gln Lys Met Lys Gly Lys Val Met Val Asp 
            260                 265                 270         


Glu Asn Thr Trp Thr Asn Leu Leu Ser Arg Val Thr Leu Leu Glu Thr 
        275                 280                 285             


Glu Met Leu Leu Ser Lys Lys Asn Asp Glu Phe Ile Glu Phe Asn Glu 
    290                 295                 300                 


Val Ser Glu Asp Tyr Ala Ser Cys Ser Asp Met Asp Leu Leu Asn Pro 
305                 310                 315                 320 


His Arg Lys Ser Glu Val Glu Arg Pro Ala Ser Ile Pro Leu Ser Ser 
                325                 330                 335     


Gly Tyr Ser Thr Ala Ser Ser Asp Ser Thr Pro Arg Ala Ser Thr Val 
            340                 345                 350         


Asn Tyr Cys Gly Leu Asn Glu Ile Ser Glu Asn Phe Pro Ala Trp Ser 
        355                 360                 365             


Ala Thr Ser Ser Cys Ser Ser Leu Ser Trp Leu Leu Arg Gly His Thr 
    370                 375                 380                 


Ser Tyr Leu Ser Ser Gln Ser Phe Ala Trp Pro Leu Ser Cys Val 
385                 390                 395                 


<210> 7530
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7530
Xaa Cys Ala Gly Ala Glu Arg Pro Arg Arg Arg Gly Arg Leu Trp Asp 
1               5                   10                  15      


Ser Ser Gly Val Pro Gln Arg Gln Lys Arg Pro Gly Pro Trp Arg Thr 
            20                  25                  30          


Gln Thr Gln Glu Gln Met Ser Arg Asp Val Cys Ile His Thr Trp Pro 
        35                  40                  45              


Cys Thr Tyr Tyr Leu Glu Pro Lys Arg Arg Trp Val Thr Gly Gln Leu 
    50                  55                  60                  


Ser Leu Thr Ser Leu Ser Leu Arg Phe Met Thr Asp Ser Thr Gly Glu 
65                  70                  75                  80  


Ile Leu Val Ser Phe Pro Leu Ser Ser Ile Val Glu Ile Lys Lys Glu 
                85                  90                  95      


Ala Ser His Phe Ile Phe Ser Ser Ile Thr Ile Leu Glu Lys Gly His 
            100                 105                 110         


Ala Lys His Trp Phe Ser Ser Leu Arg Pro Ser Arg Asn Val Val Phe 
        115                 120                 125             


Ser Ile Ile Glu His Phe Trp Arg Glu Leu Leu Leu Ser Gln Pro Gly 
    130                 135                 140                 


Ala Val Ala Asp Ala Ser Val Pro Arg Thr Arg Gly Glu Glu Leu Thr 
145                 150                 155                 160 


Gly Leu Met Ala Gly Ser Gln Lys Arg Leu Glu Asp Thr Ala Arg Val 
                165                 170                 175     


Leu His His Gln Gly Gln Gln Leu Asp Ser Val Met Arg Gly Leu Asp 
            180                 185                 190         


Lys Met Glu Ser Asp Leu Glu Val Ala Asp Arg Leu Leu Thr Glu Leu 
        195                 200                 205             


Glu Ser Pro Ala Trp Trp Pro Phe Ser Ser Lys Leu Trp Lys Thr Pro 
    210                 215                 220                 


Pro Glu Thr Lys Pro Arg Glu Asp Val Ser Met Thr Ser Cys Glu Pro 
225                 230                 235                 240 


Phe Gly Lys Glu Gly Ile Leu Ile Lys Ile Pro Ala Val Ile Ser His 
                245                 250                 255     


Arg Thr Glu Ser His Val Lys Pro Gly Arg Leu Thr Val Leu Val Ser 
            260                 265                 270         


Gly Leu Glu Ile His Asp Ser Ser Ser Leu Leu Met His Arg Phe Glu 
        275                 280                 285             


Arg Glu Asp Val Asp Asp Ile Lys Val His Ser Pro Tyr Glu Ile Ser 
    290                 295                 300                 


Ile Arg Gln Arg Phe Ile Gly Lys Pro Asp Met Ala Tyr Arg Leu Ile 
305                 310                 315                 320 


Ser Ala Lys Met Pro Glu Val Ile Pro Ile Leu Glu Val Gln Phe Ser 
                325                 330                 335     


Lys Lys Met Glu Leu Leu Glu Asp Ala Leu Val Leu Arg Ser Ala Arg 
            340                 345                 350         


Thr Ser Ser Pro Ala Glu Lys Ser Cys Ser Val Trp His Ala Ala Ser 
        355                 360                 365             


Gly Leu Met Gly Arg Thr Leu His Arg Glu Pro Pro Ala Gly Asp Gln 
    370                 375                 380                 


Glu Gly Thr Ala Leu His Leu Gln Thr Ser Leu Pro Ala Leu Ser Glu 
385                 390                 395                 400 


Ala Asp Thr Gln Glu Leu Thr Gln Gly Phe Arg Pro Met Ser Leu Ser 
                405                 410                 415     


Thr Gln Thr Val Leu Val Met Leu Cys Ser Glu Ser Ala Gly Ala Leu 
            420                 425                 430         


Trp Arg Gln Arg Leu Ser 
        435             


<210> 7531
<211> 236
<212> PRT
<213> Homo sapiens

<400> 7531
Met Thr Gly Tyr Glu Ala Arg Leu Ile Thr Phe Gly Thr Trp Met Tyr 
1               5                   10                  15      


Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Ala Ile Gly 
            20                  25                  30          


Gln Glu Asp Lys Val Gln Cys Phe His Cys Gly Gly Gly Leu Ala Asn 
        35                  40                  45              


Trp Lys Pro Lys Glu Asp Pro Trp Glu Gln His Ala Lys Trp Tyr Pro 
    50                  55                  60                  


Gly Cys Lys Tyr Leu Leu Glu Glu Lys Gly His Glu Tyr Ile Asn Asn 
65                  70                  75                  80  


Ile His Leu Thr Arg Ser Leu Glu Gly Ala Leu Val Gln Thr Thr Lys 
                85                  90                  95      


Lys Thr Pro Ser Leu Thr Lys Arg Ile Ser Asp Thr Ile Phe Pro Asn 
            100                 105                 110         


Pro Met Leu Gln Glu Ala Ile Arg Met Gly Phe Asp Phe Lys Asp Val 
        115                 120                 125             


Lys Lys Ile Met Glu Glu Arg Ile Gln Thr Ser Gly Ser Asn Tyr Lys 
    130                 135                 140                 


Thr Leu Glu Val Leu Val Ala Asp Leu Val Ser Ala Gln Lys Asp Thr 
145                 150                 155                 160 


Thr Glu Asn Glu Leu Asn Gln Thr Ser Leu Gln Arg Glu Ile Ser Pro 
                165                 170                 175     


Glu Glu Pro Leu Arg Arg Leu Gln Glu Glu Lys Leu Cys Lys Ile Cys 
            180                 185                 190         


Met Asp Arg His Ile Ala Val Val Phe Ile Pro Cys Gly His Leu Val 
        195                 200                 205             


Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Arg Cys Pro Met Cys Ser 
    210                 215                 220                 


Ala Val Ile Asp Phe Lys Gln Arg Val Phe Met Ser 
225                 230                 235     


<210> 7532
<211> 94
<212> PRT
<213> Homo sapiens

<400> 7532
Met Asn Pro Thr Asn Pro Phe Ser Gly Gln Gln Pro Ser Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ser Ser Asn Val Gly Thr Leu Pro Ser Lys Pro Pro Phe Arg 
            20                  25                  30          


Phe Gly Gln Pro Ser Leu Phe Gly Gln Asn Ser Thr Leu Ser Gly Lys 
        35                  40                  45              


Ser Ser Gly Phe Ser Gln Val Ser Ser Phe Pro Ala Ser Ser Gly Val 
    50                  55                  60                  


Ser His Ser Ser Ser Val Gln Thr Leu Gly Phe Thr Gln Thr Ser Ser 
65                  70                  75                  80  


Val Gly Pro Phe Ser Gly Leu Glu His Thr Ser Thr Phe Val 
                85                  90                  


<210> 7533
<211> 240
<212> PRT
<213> Homo sapiens

<400> 7533
Met Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser Val Ser Ser Leu 
            20                  25                  30          


Ile Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His 
        35                  40                  45              


Gly Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp Gly Leu Leu Arg 
    50                  55                  60                  


Gly Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala Val Pro Pro Arg 
65                  70                  75                  80  


Lys Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn Glu Asp Phe Arg 
                85                  90                  95      


Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu 
            100                 105                 110         


Gln Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu Ile 
        115                 120                 125             


Pro Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys Ile Leu Ile Arg 
    130                 135                 140                 


Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser 
145                 150                 155                 160 


Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gln 
                165                 170                 175     


Gly Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser Ser Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ala Ala Asp Lys Pro Leu Ala Phe Ser Gly Trp 
        195                 200                 205             


Ala Ser Gly Cys Pro Ser Gly Thr Leu Ser Asp Ser Gly Arg Asn Ser 
    210                 215                 220                 


Leu Ser Ser Leu Pro Thr Tyr Ser Thr Gly Gly Ala Glu Pro Thr Thr 
225                 230                 235                 240 


<210> 7534
<211> 438
<212> PRT
<213> Homo sapiens

<400> 7534
Met Cys Pro Lys Asn Ala Ser Tyr Tyr Gly Asn Arg Ala Ala Thr Leu 
1               5                   10                  15      


Met Met Leu Gly Arg Phe Arg Glu Ala Leu Gly Asp Ala Gln Gln Ser 
            20                  25                  30          


Val Arg Leu Asp Asp Ser Phe Val Arg Gly His Leu Arg Glu Gly Lys 
        35                  40                  45              


Cys His Leu Ser Leu Gly Asn Ala Met Ala Ala Cys Arg Ser Phe Gln 
    50                  55                  60                  


Arg Ala Leu Glu Leu Asp His Lys Asn Ala Gln Ala Gln Gln Glu Phe 
65                  70                  75                  80  


Lys Asn Ala Asn Ala Val Met Glu Tyr Glu Lys Ile Ala Glu Thr Asp 
                85                  90                  95      


Phe Glu Lys Arg Asp Phe Arg Lys Val Val Phe Cys Met Asp Arg Ala 
            100                 105                 110         


Leu Glu Phe Ala Pro Ala Cys His Arg Phe Lys Ile Leu Lys Ala Glu 
        115                 120                 125             


Cys Leu Ala Met Leu Gly Arg Tyr Pro Glu Ala Gln Ser Val Ala Ser 
    130                 135                 140                 


Asp Ile Leu Arg Met Asp Ser Thr Asn Ala Asp Ala Leu Tyr Val Arg 
145                 150                 155                 160 


Gly Leu Cys Leu Tyr Tyr Glu Asp Cys Ile Glu Lys Ala Val Gln Phe 
                165                 170                 175     


Phe Val Gln Ala Leu Arg Met Ala Pro Asp His Glu Lys Ala Cys Ile 
            180                 185                 190         


Ala Cys Arg Asn Ala Lys Ala Leu Lys Ala Lys Lys Glu Asp Gly Asn 
        195                 200                 205             


Lys Ala Phe Lys Glu Gly Asn Tyr Lys Leu Ala Tyr Glu Leu Tyr Thr 
    210                 215                 220                 


Glu Ala Leu Gly Ile Asp Pro Asn Asn Ile Lys Thr Asn Ala Lys Leu 
225                 230                 235                 240 


Tyr Cys Asn Arg Gly Thr Val Asn Ser Lys Leu Arg Lys Leu Asp Asp 
                245                 250                 255     


Ala Ile Glu Asp Cys Thr Asn Ala Val Lys Leu Asp Asp Thr Tyr Ile 
            260                 265                 270         


Lys Ala Tyr Leu Arg Arg Ala Gln Cys Tyr Met Asp Thr Glu Gln Tyr 
        275                 280                 285             


Glu Glu Ala Val Arg Asp Tyr Glu Lys Val Tyr Gln Thr Glu Lys Thr 
    290                 295                 300                 


Lys Glu His Lys Gln Leu Leu Lys Asn Ala Gln Leu Glu Leu Lys Lys 
305                 310                 315                 320 


Ser Lys Arg Lys Asp Tyr Tyr Lys Ile Leu Gly Val Asp Lys Asn Ala 
                325                 330                 335     


Ser Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Arg Ala Leu Met His 
            340                 345                 350         


His Pro Asp Arg His Ser Gly Ala Ser Ala Glu Val Gln Lys Glu Glu 
        355                 360                 365             


Glu Lys Lys Phe Lys Glu Val Gly Glu Ala Phe Thr Ile Leu Ser Asp 
    370                 375                 380                 


Pro Lys Lys Lys Thr Arg Tyr Asp Ser Gly Gln Asp Leu Asp Glu Glu 
385                 390                 395                 400 


Gly Met Asn Met Gly Asp Phe Asp Pro Asn Asn Ile Phe Lys Ala Phe 
                405                 410                 415     


Phe Gly Gly Pro Gly Gly Phe Ser Phe Glu Ala Ser Gly Pro Gly Asn 
            420                 425                 430         


Phe Phe Phe Gln Phe Gly 
        435             


<210> 7535
<211> 225
<212> PRT
<213> Homo sapiens

<400> 7535
Met Glu Glu Glu Glu Met Asn Asp Gly Ser Gln Met Val Arg Ser Gln 
1               5                   10                  15      


Glu Ser Leu Thr Phe Gln Asp Val Ala Val Asp Phe Thr Arg Glu Glu 
            20                  25                  30          


Trp Asp Gln Leu Tyr Pro Ala Gln Lys Asn Leu Tyr Arg Asp Val Met 
        35                  40                  45              


Leu Glu Asn Tyr Arg Asn Leu Val Ala Leu Gly Tyr Gln Leu Cys Lys 
    50                  55                  60                  


Pro Glu Val Ile Ala Gln Leu Glu Leu Glu Glu Glu Trp Val Ile Glu 
65                  70                  75                  80  


Arg Asp Ser Leu Leu Asp Thr His Pro Gly Asp Gln Ser His Val Met 
                85                  90                  95      


Ser Val Val Arg Ser Ser Val His Ala Arg Trp Ile Val Gly Lys Val 
            100                 105                 110         


Ile Gly Thr Lys Met Gln Lys Thr Ala Lys Val Arg Val Thr Arg Leu 
        115                 120                 125             


Val Leu Asp Pro Tyr Leu Leu Lys Tyr Phe Asn Lys Arg Lys Thr Tyr 
    130                 135                 140                 


Phe Ala His Asp Ala Leu Gln Gln Cys Thr Val Gly Asp Ile Val Leu 
145                 150                 155                 160 


Leu Arg Ala Leu Pro Val Pro Arg Ala Lys His Val Lys His Glu Leu 
                165                 170                 175     


Ala Glu Ile Val Phe Lys Val Gly Lys Val Ile Asp Pro Val Thr Gly 
            180                 185                 190         


Lys Pro Cys Ala Gly Thr Thr Tyr Leu Glu Ser Pro Leu Ser Ser Glu 
        195                 200                 205             


Thr Thr Gln Leu Ser Lys Asn Leu Glu Glu Leu Asn Ile Ser Ser Ala 
    210                 215                 220                 


Gln 
225 


<210> 7536
<211> 250
<212> PRT
<213> Homo sapiens

<400> 7536
Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Thr Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Thr Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu 
                245                 250 


<210> 7537
<211> 128
<212> PRT
<213> Homo sapiens

<400> 7537
Met Leu Cys Trp Gly Tyr Trp Ser Leu Gly Gln Pro Gly Ile Ser Thr 
1               5                   10                  15      


Asn Leu Gln Gly Ile Val Ala Glu Pro Gln Val Cys Gly Phe Ile Ser 
            20                  25                  30          


Asp Arg Ser Val Lys Glu Val Ala Cys Gly Gly Asn His Ser Val Phe 
        35                  40                  45              


Leu Leu Glu Asp Gly Glu Val Tyr Thr Cys Gly Leu Asn Thr Lys Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Arg Glu Gly Asn Lys Pro Glu Gln Ile Gly Ala 
65                  70                  75                  80  


Leu Ala Asp Gln His Ile Ile His Val Ala Cys Gly Glu Ser His Ser 
                85                  90                  95      


Leu Ala Leu Ser Asp Arg Gly Gln Leu Phe Ser Trp Gly Ala Gly Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Met Thr Thr Glu Asp Ser Val Ala Val Pro 
        115                 120                 125             


<210> 7538
<211> 538
<212> PRT
<213> Homo sapiens

<400> 7538
Met Asp Val Asp Lys Glu Leu Gly Met Glu Ser Val Lys Ala Gly Ala 
1               5                   10                  15      


Ser Gly Lys Pro Glu Met Arg Leu Gly Thr Gln Glu Glu Thr Ser Glu 
            20                  25                  30          


Gly Asp Ala Asn Glu Ser Ser Leu Leu Val Leu Ser Ser Asn Val Pro 
        35                  40                  45              


Leu Leu Ala Leu Glu Phe Leu Glu Ile Ala Gln Ala Lys Glu Lys Ala 
    50                  55                  60                  


Phe Leu Pro Met Val Ser His Thr Phe His Met Arg Thr Glu Glu Ser 
65                  70                  75                  80  


Asp Ala Ser Gln Glu Gly Asp Asp Leu Pro Lys Ser Ser Ala Asn Thr 
                85                  90                  95      


Ser His Pro Lys Gln Asp Asp Ser Pro Lys Ser Ser Glu Glu Thr Ile 
            100                 105                 110         


Gln Pro Lys Glu Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln 
        115                 120                 125             


Ser Lys Lys Glu Asp Leu Pro Lys Ser Ser Glu Lys Ala Ile Gln Pro 
    130                 135                 140                 


Lys Glu Ser Asn Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys 
145                 150                 155                 160 


Leu Gly Asn Ile Pro Lys Ala Ser Val Lys Pro Ser Gln Pro Lys Glu 
                165                 170                 175     


Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys Glu 
            180                 185                 190         


Asp Leu Pro Lys Ser Ser Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp 
        195                 200                 205             


Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile 
    210                 215                 220                 


Ala Lys Thr Ser Val Lys Pro Ser Gln Pro Lys Glu Ser Asp Ile Pro 
225                 230                 235                 240 


Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys 
                245                 250                 255     


Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Pro Lys Ala 
            260                 265                 270         


Ser Val Lys Pro Ser Gln Pro Lys Glu Gly Asp Ile Ser Lys Ser Pro 
        275                 280                 285             


Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Leu Pro Lys Ser Leu Glu 
    290                 295                 300                 


Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu 
305                 310                 315                 320 


Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu Thr 
                325                 330                 335     


Ile Gln Pro Lys Lys Gly Asp Ile Pro Lys Ser Pro Glu Glu Ala Ile 
            340                 345                 350         


Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Lys Gln Ala Ile Gln 
        355                 360                 365             


Pro Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala Ile Pro Pro 
    370                 375                 380                 


Lys Glu Ile Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys 
385                 390                 395                 400 


Glu Asp Asp Ser Pro Lys Ser Leu Glu Glu Ala Thr Pro Ser Lys Glu 
                405                 410                 415     


Gly Asp Ile Leu Lys Pro Glu Glu Glu Thr Met Glu Phe Pro Glu Gly 
            420                 425                 430         


Asp Lys Val Lys Val Ile Leu Ser Lys Glu Asp Phe Glu Ala Ser Leu 
        435                 440                 445             


Lys Glu Ala Gly Glu Arg Leu Val Ala Val Asp Phe Ser Ala Thr Trp 
    450                 455                 460                 


Cys Gly Pro Cys Arg Thr Ile Arg Pro Phe Phe His Ala Leu Ser Val 
465                 470                 475                 480 


Lys His Glu Asp Val Val Phe Leu Glu Val Asp Ala Asp Asn Cys Glu 
                485                 490                 495     


Glu Val Val Arg Glu Cys Ala Ile Met Cys Val Pro Thr Phe Gln Phe 
            500                 505                 510         


Tyr Lys Lys Glu Glu Lys Val Asp Glu Leu Cys Gly Ala Leu Lys Glu 
        515                 520                 525             


Lys Leu Glu Ala Val Ile Ala Glu Leu Lys 
    530                 535             


<210> 7539
<211> 50
<212> PRT
<213> Homo sapiens

<400> 7539
Met Ala Ser Glu Glu Leu Gln Lys Asp Leu Glu Glu Val Lys Val Leu 
1               5                   10                  15      


Leu Glu Lys Ala Thr Arg Lys Arg Val Arg Asp Ala Leu Thr Ala Glu 
            20                  25                  30          


Lys Ser Lys Ile Glu Thr Glu Ile Lys Asn Lys Met Gln Gln Lys Ser 
        35                  40                  45              


Gln Lys 
    50  


<210> 7540
<211> 508
<212> PRT
<213> Homo sapiens

<400> 7540
Met Ala Thr Asp Trp Leu Gly Ser Ile Val Ser Ile Asn Cys Gly Asp 
1               5                   10                  15      


Ser Leu Gly Val Tyr Gln Gly Arg Val Ser Ala Val Asp Gln Val Ser 
            20                  25                  30          


Gln Thr Ile Ser Leu Thr Arg Pro Phe His Asn Gly Val Lys Cys Leu 
        35                  40                  45              


Val Pro Glu Val Thr Phe Arg Ala Gly Asp Ile Thr Glu Leu Lys Ile 
    50                  55                  60                  


Leu Glu Ile Pro Gly Pro Gly Asp Asn Gln His Phe Gly Asp Leu His 
65                  70                  75                  80  


Gln Thr Glu Leu Gly Pro Ser Gly Ala Gly Cys Gln Val Gly Ile Asn 
                85                  90                  95      


Gln Asn Gly Thr Gly Lys Phe Val Lys Lys Pro Ala Ser Ser Ser Ser 
            100                 105                 110         


Ala Pro Gln Asn Ile Pro Lys Arg Thr Asp Val Lys Ser Gln Asp Val 
        115                 120                 125             


Ala Val Ser Pro Gln Gln Gln Gln Cys Ser Lys Ser Tyr Val Asp Arg 
    130                 135                 140                 


His Met Glu Ser Leu Ser Gln Ser Lys Ser Phe Arg Arg Arg His Asn 
145                 150                 155                 160 


Ser Trp Ser Ser Ser Ser Arg His Pro Asn Gln Ala Thr Pro Lys Lys 
                165                 170                 175     


Ser Gly Leu Lys Asn Gly Gln Met Lys Asn Lys Asp Asp Glu Cys Phe 
            180                 185                 190         


Gly Asp Asp Ile Glu Glu Ile Pro Asp Thr Asp Phe Asp Phe Glu Gly 
        195                 200                 205             


Asn Leu Ala Leu Phe Asp Lys Ala Ala Val Phe Glu Glu Ile Asp Thr 
    210                 215                 220                 


Tyr Glu Arg Arg Ser Gly Thr Arg Ser Arg Gly Ile Pro Asn Glu Arg 
225                 230                 235                 240 


Pro Thr Arg Tyr Arg His Asp Glu Asn Ile Leu Glu Ser Glu Pro Ile 
                245                 250                 255     


Val Tyr Arg Arg Ile Ile Val Pro His Asn Val Ser Lys Glu Phe Cys 
            260                 265                 270         


Thr Asp Ser Gly Leu Val Val Pro Ser Ile Ser Tyr Glu Leu His Lys 
        275                 280                 285             


Lys Leu Leu Ser Val Ala Glu Lys His Gly Leu Thr Leu Glu Arg Arg 
    290                 295                 300                 


Leu Glu Met Thr Gly Val Cys Ala Ser Gln Met Ala Leu Thr Leu Leu 
305                 310                 315                 320 


Gly Gly Pro Asn Arg Leu Asn Pro Lys Asn Val His Gln Arg Pro Thr 
                325                 330                 335     


Val Ala Leu Leu Cys Gly Pro His Val Lys Gly Ala Gln Gly Ile Ser 
            340                 345                 350         


Cys Gly Arg His Leu Ala Asn His Asp Val Gln Val Ile Leu Phe Leu 
        355                 360                 365             


Pro Asn Phe Val Lys Met Leu Glu Ser Ile Thr Asn Glu Leu Ser Leu 
    370                 375                 380                 


Phe Ser Lys Thr Gln Gly Gln Gln Val Ser Ser Leu Lys Asp Leu Pro 
385                 390                 395                 400 


Thr Ser Pro Val Asp Leu Val Ile Asn Cys Leu Asp Cys Pro Glu Asn 
                405                 410                 415     


Val Phe Leu Arg Asp Gln Pro Trp Tyr Lys Ala Ala Val Ala Trp Ala 
            420                 425                 430         


Asn Gln Asn Arg Ala Pro Val Leu Ser Ile Asp Pro Pro Val His Glu 
        435                 440                 445             


Val Glu Gln Gly Ile Asp Ala Lys Trp Ser Leu Ala Leu Gly Leu Pro 
    450                 455                 460                 


Leu Pro Leu Gly Glu His Ala Gly Arg Ile Tyr Leu Cys Asp Ile Gly 
465                 470                 475                 480 


Ile Pro Gln Gln Val Phe Gln Glu Val Gly Ile Asn Tyr His Ser Pro 
                485                 490                 495     


Phe Gly Cys Lys Phe Val Ile Pro Leu His Ser Ala 
            500                 505             


<210> 7541
<211> 1281
<212> PRT
<213> Homo sapiens

<400> 7541
Met Thr Phe Tyr Ser Trp Ile Pro Tyr His Arg Gln Ala Pro Leu Asn 
1               5                   10                  15      


His Arg Arg Val Cys Ser Ala Glu Gly Ala Gly Ser Pro Gly Pro Ala 
            20                  25                  30          


Leu Asp Pro Arg Trp Leu Pro Thr Glu Ala His Leu Leu Glu Ala His 
        35                  40                  45              


Arg Leu Leu Leu Gln Ser Val Leu Cys Asp Arg Pro Arg Glu Ser Ile 
    50                  55                  60                  


Gln Leu His Phe Arg Leu Ser Met Ala Ser Gln Leu Gln Val Phe Ser 
65                  70                  75                  80  


Pro Pro Ser Val Ser Ser Ser Ala Phe Cys Ser Ala Lys Lys Leu Lys 
                85                  90                  95      


Ile Glu Pro Ser Gly Trp Asp Val Ser Gly Gln Ser Ser Asn Asp Lys 
            100                 105                 110         


Tyr Tyr Thr His Ser Lys Thr Leu Pro Ala Thr Gln Gly Gln Ala Asn 
        115                 120                 125             


Ser Ser His Gln Val Ala Asn Phe Asn Ile Pro Ala Tyr Asp Gln Gly 
    130                 135                 140                 


Leu Leu Leu Pro Ala Pro Ala Val Glu His Ile Val Val Thr Ala Ala 
145                 150                 155                 160 


Asp Ser Ser Gly Ser Ala Ala Thr Ser Thr Phe Gln Ser Ser Gln Thr 
                165                 170                 175     


Leu Thr His Arg Ser Asn Val Ser Leu Leu Glu Pro Tyr Gln Lys Cys 
            180                 185                 190         


Gly Leu Lys Arg Lys Ser Glu Glu Val Asp Ser Asn Gly Ser Val Gln 
        195                 200                 205             


Ile Ile Glu Glu His Pro Pro Leu Met Leu Gln Asn Arg Thr Val Val 
    210                 215                 220                 


Gly Ala Ala Ala Thr Thr Thr Thr Val Thr Thr Lys Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Gly Glu Gly Asp Tyr Gln Leu Val Gln His Glu Ile Leu Cys Ser 
                245                 250                 255     


Met Thr Asn Ser Tyr Glu Val Leu Glu Phe Leu Gly Arg Gly Thr Phe 
            260                 265                 270         


Gly Gln Val Ala Lys Cys Trp Lys Arg Ser Thr Lys Glu Ile Val Ala 
        275                 280                 285             


Ile Lys Ile Leu Lys Asn His Pro Ser Tyr Ala Arg Gln Gly Gln Ile 
    290                 295                 300                 


Glu Val Ser Ile Leu Ser Arg Leu Ser Ser Glu Asn Ala Asp Glu Tyr 
305                 310                 315                 320 


Asn Phe Val Arg Ser Tyr Glu Cys Phe Gln His Lys Asn His Thr Cys 
                325                 330                 335     


Leu Val Phe Glu Met Leu Glu Gln Asn Leu Tyr Asp Phe Leu Lys Gln 
            340                 345                 350         


Asn Lys Phe Ser Pro Leu Pro Leu Lys Tyr Ile Arg Pro Ile Leu Gln 
        355                 360                 365             


Gln Val Ala Thr Ala Leu Met Lys Leu Lys Ser Leu Gly Leu Ile His 
    370                 375                 380                 


Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val Asp Pro Val Arg Gln 
385                 390                 395                 400 


Pro Tyr Arg Val Lys Val Ile Asp Phe Gly Ser Ala Ser His Val Ser 
                405                 410                 415     


Lys Ala Val Cys Ser Thr Tyr Leu Gln Ser Arg Tyr Tyr Arg Ala Pro 
            420                 425                 430         


Glu Ile Ile Leu Gly Leu Pro Phe Cys Glu Ala Ile Asp Met Trp Ser 
        435                 440                 445             


Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro Leu Tyr Pro 
    450                 455                 460                 


Gly Ala Ser Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln Thr Gln Gly 
465                 470                 475                 480 


Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr Arg Phe 
                485                 490                 495     


Phe Asn Arg Asp Pro Asn Leu Gly Tyr Pro Leu Trp Arg Leu Lys Thr 
            500                 505                 510         


Pro Glu Glu His Glu Leu Glu Thr Gly Ile Lys Ser Lys Glu Ala Arg 
        515                 520                 525             


Lys Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn Met Ser 
    530                 535                 540                 


Thr Asp Leu Glu Gly Thr Asp Met Leu Ala Glu Lys Ala Asp Arg Arg 
545                 550                 555                 560 


Glu Tyr Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala Asp Lys 
                565                 570                 575     


Arg Ile Thr Pro Leu Lys Thr Leu Asn His Gln Phe Val Thr Met Thr 
            580                 585                 590         


His Leu Leu Asp Phe Pro His Ser Asn His Val Lys Ser Cys Phe Gln 
        595                 600                 605             


Asn Met Glu Ile Cys Lys Arg Arg Val His Met Tyr Asp Thr Val Ser 
    610                 615                 620                 


Gln Ile Lys Ser Pro Phe Thr Thr His Val Ala Pro Asn Thr Ser Thr 
625                 630                 635                 640 


Asn Leu Thr Met Ser Phe Ser Asn Gln Leu Asn Thr Val His Asn Gln 
                645                 650                 655     


Ala Ser Val Leu Ala Ser Ser Ser Thr Ala Ala Ala Ala Thr Leu Ser 
            660                 665                 670         


Leu Ala Asn Ser Asp Val Ser Leu Leu Asn Tyr Gln Ser Ala Leu Tyr 
        675                 680                 685             


Pro Ser Ser Ala Ala Pro Val Pro Gly Val Ala Gln Gln Gly Val Ser 
    690                 695                 700                 


Leu Gln Pro Gly Thr Thr Gln Ile Cys Thr Gln Thr Asp Pro Phe Gln 
705                 710                 715                 720 


Gln Thr Phe Ile Val Cys Pro Pro Ala Phe Gln Thr Gly Leu Gln Ala 
                725                 730                 735     


Thr Thr Lys His Ser Gly Phe Pro Val Arg Met Asp Asn Ala Val Pro 
            740                 745                 750         


Ile Val Pro Gln Ala Pro Ala Ala Gln Pro Leu Gln Ile Gln Ser Gly 
        755                 760                 765             


Val Leu Thr Gln Gly Ser Cys Thr Pro Leu Met Val Ala Thr Leu His 
    770                 775                 780                 


Pro Gln Val Ala Thr Ile Thr Pro Gln Tyr Ala Val Pro Phe Thr Leu 
785                 790                 795                 800 


Ser Cys Ala Ala Gly Arg Pro Ala Leu Val Glu Gln Thr Ala Ala Val 
                805                 810                 815     


Leu Gln Ala Trp Pro Gly Gly Thr Gln Gln Ile Leu Leu Pro Ser Thr 
            820                 825                 830         


Trp Gln Gln Leu Pro Gly Val Ala Leu His Asn Ser Val Gln Pro Thr 
        835                 840                 845             


Ala Met Ile Pro Glu Ala Met Gly Ser Gly Gln Gln Leu Ala Asp Trp 
    850                 855                 860                 


Arg Asn Ala His Ser His Gly Asn Gln Tyr Ser Thr Ile Met Gln Gln 
865                 870                 875                 880 


Pro Ser Leu Leu Thr Asn His Val Thr Leu Ala Thr Ala Gln Pro Leu 
                885                 890                 895     


Asn Val Gly Val Ala His Val Val Arg Gln Gln Gln Ser Ser Ser Leu 
            900                 905                 910         


Pro Ser Lys Lys Asn Lys Gln Ser Ala Pro Val Ser Ser Lys Ser Ser 
        915                 920                 925             


Leu Asp Val Leu Pro Ser Gln Val Tyr Ser Leu Val Gly Ser Ser Pro 
    930                 935                 940                 


Leu Arg Thr Thr Ser Ser Tyr Asn Ser Leu Val Pro Val Gln Asp Gln 
945                 950                 955                 960 


His Gln Pro Ile Ile Ile Pro Asp Thr Pro Ser Pro Pro Val Ser Val 
                965                 970                 975     


Ile Thr Ile Arg Ser Asp Thr Asp Glu Glu Glu Asp Asn Lys Tyr Lys 
            980                 985                 990         


Pro Ser Ser Ser Gly Leu Lys Pro  Arg Ser Asn Val Ile  Ser Tyr Val 
        995                 1000                 1005             


Thr Val  Asn Asp Ser Pro Asp  Ser Asp Ser Ser Leu  Ser Ser Pro 
    1010                 1015                 1020             


Tyr Ser  Thr Asp Thr Leu Ser  Ala Leu Arg Gly Asn  Ser Gly Ser 
    1025                 1030                 1035             


Val Leu  Glu Gly Pro Gly Arg  Val Val Ala Asp Gly  Thr Gly Thr 
    1040                 1045                 1050             


Arg Thr  Ile Ile Val Pro Pro  Leu Lys Thr Gln Leu  Gly Asp Cys 
    1055                 1060                 1065             


Thr Val  Ala Thr Gln Ala Ser  Gly Leu Leu Ser Asn  Lys Thr Lys 
    1070                 1075                 1080             


Pro Val  Ala Ser Val Ser Gly  Gln Ser Ser Gly Cys  Cys Ile Thr 
    1085                 1090                 1095             


Pro Thr  Gly Tyr Arg Ala Gln  Arg Gly Gly Thr Ser  Ala Ala Gln 
    1100                 1105                 1110             


Pro Leu  Asn Leu Ser Gln Asn  Gln Gln Ser Ser Ala  Ala Pro Thr 
    1115                 1120                 1125             


Ser Gln  Glu Arg Ser Ser Asn  Pro Ala Pro Arg Arg  Gln Gln Ala 
    1130                 1135                 1140             


Phe Val  Ala Pro Leu Ser Gln  Ala Pro Tyr Thr Phe  Gln His Gly 
    1145                 1150                 1155             


Ser Pro  Leu His Ser Thr Gly  His Pro His Leu Ala  Pro Ala Pro 
    1160                 1165                 1170             


Ala His  Leu Pro Ser Gln Ala  His Leu Tyr Thr Tyr  Ala Ala Pro 
    1175                 1180                 1185             


Thr Ser  Ala Ala Ala Leu Gly  Ser Thr Ser Ser Ile  Ala His Leu 
    1190                 1195                 1200             


Phe Ser  Pro Gln Gly Ser Ser  Arg His Ala Ala Ala  Tyr Thr Thr 
    1205                 1210                 1215             


His Pro  Ser Thr Leu Val His  Gln Val Pro Val Ser  Val Gly Pro 
    1220                 1225                 1230             


Ser Leu  Leu Thr Ser Ala Ser  Val Ala Pro Ala Gln  Tyr Gln His 
    1235                 1240                 1245             


Gln Phe  Ala Thr Gln Ser Tyr  Ile Gly Ser Ser Arg  Gly Ser Thr 
    1250                 1255                 1260             


Ile Tyr  Thr Gly Tyr Pro Leu  Ser Pro Thr Lys Ile  Ser Gln Tyr 
    1265                 1270                 1275             


Ser Tyr  Leu 
    1280     


<210> 7542
<211> 356
<212> PRT
<213> Homo sapiens

<400> 7542
Met Thr Ser Val Thr Arg Ser Glu Ile Ile Asp Glu Lys Gly Pro Val 
1               5                   10                  15      


Met Ser Lys Thr His Asp His Gln Leu Glu Ser Ser Leu Ser Pro Val 
            20                  25                  30          


Glu Val Phe Ala Lys Thr Ser Ala Ser Leu Glu Met Asn Gln Gly Val 
        35                  40                  45              


Ser Glu Glu Arg Ile His Leu Gly Ser Ser Pro Lys Lys Gly Gly Asn 
    50                  55                  60                  


Cys Asp Leu Ser His Gln Glu Arg Leu Gln Ser Lys Ser Leu His Leu 
65                  70                  75                  80  


Ser Pro Gln Glu Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp 
                85                  90                  95      


Arg Arg Ala Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro 
            100                 105                 110         


Ile His Gln Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu 
        115                 120                 125             


Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe 
    130                 135                 140                 


Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser 
145                 150                 155                 160 


Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys 
                165                 170                 175     


His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe 
            180                 185                 190         


Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val 
        195                 200                 205             


Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr 
    210                 215                 220                 


Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu 
225                 230                 235                 240 


Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro 
                245                 250                 255     


Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro 
            260                 265                 270         


Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met 
        275                 280                 285             


Glu Leu Val Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala 
    290                 295                 300                 


Phe Met Asp Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu 
305                 310                 315                 320 


Gly Lys Arg Ser Met Gln Gln Leu Asp Pro Ser Pro Ala Arg Lys Leu 
                325                 330                 335     


Leu Lys Leu Gln Leu Gln Asn Pro Pro Ala Ile His Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Cys Gln 
        355     


<210> 7543
<211> 915
<212> PRT
<213> Homo sapiens

<400> 7543
Met Gln Gly Pro Asp Ala Pro Leu Leu Leu Ser Ala Arg Glu Leu Gly 
1               5                   10                  15      


Pro Gly Arg Arg Gly Ser Ala Ser Trp Tyr Arg Gln Glu Gly Gly Ala 
            20                  25                  30          


Val Cys Asn Trp Leu Arg Lys Pro Gln Pro Leu Glu Pro Arg Thr Ser 
        35                  40                  45              


Phe Pro Ser Ala Arg Arg Ser Glu Phe Arg Pro Pro Arg Arg Leu Pro 
    50                  55                  60                  


Trp Ala Gly Pro Ala Ser Ala Gln Ser Glu Glu Gly His Ala Gly Gly 
65                  70                  75                  80  


Arg Cys Gln Ala Gly Ser Pro Ala Pro Ala Arg Arg Leu Ser Gly Ala 
                85                  90                  95      


Phe Lys Thr Leu Val Pro Gly Thr His Ala Gln Gly Ala Ser Asp Thr 
            100                 105                 110         


His Pro Leu Gly Pro Pro His Thr Pro Val Leu Asp Pro Ser Pro Gln 
        115                 120                 125             


Asp Gly Phe Pro Val Leu Trp Arg Gly Ser Ser Lys Ala Ser His Met 
    130                 135                 140                 


Asn Arg Leu Arg Asn Ala Lys Ile Tyr Val Glu Arg Ala Val Lys Gln 
145                 150                 155                 160 


Lys Lys Ile Phe Thr Ile Gln Gly Cys Tyr Pro Val Ile Arg Cys Leu 
                165                 170                 175     


Leu Arg Arg Arg Gly Trp Val Glu Lys Lys Met Val His Arg Ser Gly 
            180                 185                 190         


Pro Thr Leu Leu Pro Pro Gln Lys Asp Leu Asp Ser Ser Ala Met Gly 
        195                 200                 205             


Asp Ser Asp Thr Thr Glu Asp Glu Asp Glu Asp Glu Asp Glu Glu Phe 
    210                 215                 220                 


Gln Pro Ser Gln Leu Phe Asp Phe Asp Asp Leu Leu Lys Phe Asp Asp 
225                 230                 235                 240 


Leu Asp Gly Thr His Ala Leu Met Val Gly Leu Cys Leu Asn Leu Arg 
                245                 250                 255     


Asn Leu Pro Trp Phe Asp Glu Val Asp Ala Asn Ser Phe Phe Pro Arg 
            260                 265                 270         


Cys Tyr Cys Leu Gly Ala Glu Asp Asp Lys Lys Ala Phe Ile Glu Asp 
        275                 280                 285             


Phe Trp Leu Thr Ala Ala Arg Asn Val Leu Lys Leu Val Val Lys Ser 
    290                 295                 300                 


Glu Trp Lys Ser Tyr Pro Ile Gln Ala Val Glu Glu Glu Ala Ser Gly 
305                 310                 315                 320 


Asp Lys Gln Pro Lys Lys Gln Glu Lys Asn Pro Val Leu Val Ser Pro 
                325                 330                 335     


Glu Phe Val Asp Glu Ala Leu Cys Ala Cys Glu Glu Tyr Leu Ser Asn 
            340                 345                 350         


Leu Ala His Met Asp Ile Asp Lys Asp Leu Glu Ala Pro Leu Tyr Leu 
        355                 360                 365             


Thr Pro Glu Gly Trp Ser Leu Phe Leu Gln Arg Tyr Tyr Gln Val Val 
    370                 375                 380                 


His Glu Gly Ala Glu Leu Arg His Leu Asp Thr Gln Val Gln Arg Cys 
385                 390                 395                 400 


Glu Asp Ile Leu Gln Gln Leu Gln Ala Val Val Pro Gln Ile Asp Met 
                405                 410                 415     


Glu Gly Asp Arg Asn Ile Trp Ile Val Lys Pro Gly Ala Lys Ser Arg 
            420                 425                 430         


Gly Arg Gly Ile Met Cys Met Asp His Leu Glu Glu Met Leu Lys Leu 
        435                 440                 445             


Val Asn Gly Asn Pro Val Val Met Lys Asp Gly Lys Trp Val Val Gln 
    450                 455                 460                 


Lys Tyr Ile Glu Arg Pro Leu Leu Ile Phe Gly Thr Lys Phe Asp Leu 
465                 470                 475                 480 


Arg Gln Trp Phe Leu Val Thr Asp Trp Asn Pro Leu Thr Val Trp Phe 
                485                 490                 495     


Tyr Arg Asp Ser Tyr Ile Arg Phe Ser Thr Gln Pro Phe Ser Leu Lys 
            500                 505                 510         


Asn Leu Asp Asn Ser Val His Leu Cys Asn Asn Ser Ile Gln Lys His 
        515                 520                 525             


Leu Glu Asn Ser Cys His Arg His Pro Leu Leu Pro Pro Asp Asn Met 
    530                 535                 540                 


Trp Ser Ser Gln Arg Phe Gln Ala His Leu Gln Glu Met Gly Ala Pro 
545                 550                 555                 560 


Asn Ala Trp Ser Thr Ile Ile Val Pro Gly Met Lys Asp Ala Val Ile 
                565                 570                 575     


His Ala Leu Gln Thr Ser Gln Asp Thr Val Gln Cys Arg Lys Ala Ser 
            580                 585                 590         


Phe Glu Leu Tyr Gly Ala Asp Phe Val Phe Gly Glu Asp Phe Gln Pro 
        595                 600                 605             


Trp Leu Ile Glu Ile Asn Ala Ser Pro Thr Met Ala Pro Ser Thr Ala 
    610                 615                 620                 


Val Thr Ala Arg Leu Cys Ala Gly Val Gln Ala Asp Thr Leu Arg Val 
625                 630                 635                 640 


Val Ile Asp Arg Met Leu Asp Arg Asn Cys Asp Thr Gly Ala Phe Glu 
                645                 650                 655     


Leu Ile Tyr Lys Gln Pro Ala Val Glu Val Pro Gln Tyr Val Gly Ile 
            660                 665                 670         


Arg Leu Leu Val Glu Gly Phe Thr Ile Lys Lys Pro Met Ala Met Cys 
        675                 680                 685             


His Arg Arg Met Gly Val Arg Pro Ala Val Pro Leu Leu Thr Gln Arg 
    690                 695                 700                 


Gly Ser Gly Glu Ala Arg His His Phe Pro Ser Leu His Thr Lys Ala 
705                 710                 715                 720 


Gln Leu Pro Ser Pro His Val Leu Arg His Gln Gly Gln Val Leu Arg 
                725                 730                 735     


Arg Gln His Ser Lys Leu Val Gly Thr Lys Ala Leu Ser Thr Thr Gly 
            740                 745                 750         


Lys Ala Leu Arg Thr Leu Pro Thr Ala Lys Val Phe Ile Ser Leu Pro 
        755                 760                 765             


Pro Asn Leu Asp Phe Lys Val Ala Pro Ser Ile Leu Lys Pro Arg Lys 
    770                 775                 780                 


Ala Pro Ala Leu Leu Cys Leu Arg Gly Pro Gln Leu Glu Val Pro Cys 
785                 790                 795                 800 


Cys Leu Cys Pro Leu Lys Ser Glu Gln Phe Leu Ala Pro Val Gly Arg 
                805                 810                 815     


Ser Arg Pro Lys Ala Asn Ser Arg Pro Asp Cys Asp Lys Pro Arg Ala 
            820                 825                 830         


Glu Ala Cys Pro Met Lys Arg Leu Ser Pro Leu Lys Pro Leu Pro Leu 
        835                 840                 845             


Val Gly Thr Phe Gln Arg Arg Arg Gly Leu Gly Asp Met Lys Leu Gly 
    850                 855                 860                 


Lys Pro Leu Leu Arg Phe Pro Thr Ala Leu Val Leu Asp Pro Thr Pro 
865                 870                 875                 880 


Asn Lys Lys Lys Gln Val Lys Tyr Leu Gly Leu Asp Ser Ile Ala Val 
                885                 890                 895     


Gly Gly Ser Arg Val Asp Gly Ala Arg Pro Cys Thr Pro Gly Ser Thr 
            900                 905                 910         


Ala Arg Ala 
        915 


<210> 7544
<211> 820
<212> PRT
<213> Homo sapiens

<400> 7544
Met Arg Ile Ser Ser Cys Ser Asp Glu Ser Ser Asn Ser Asn Ser Ser 
1               5                   10                  15      


Arg Lys Ser Asp Asn His Ser Pro Ala Val Val Thr Thr Thr Val Ser 
            20                  25                  30          


Ser Lys Lys Gln Pro Ser Val Leu Val Thr Phe Pro Lys Glu Glu Arg 
        35                  40                  45              


Lys Ser Val Ser Gly Lys Ala Ser Ile Lys Leu Ser Glu Thr Ile Ser 
    50                  55                  60                  


Glu Gly Thr Ser Asn Ser Leu Ser Thr Cys Thr Lys Ser Gly Pro Ser 
65                  70                  75                  80  


Pro Leu Ser Ser Pro Asn Gly Lys Leu Thr Val Ala Ser Pro Lys Arg 
                85                  90                  95      


Gly Gln Lys Arg Glu Glu Gly Trp Lys Glu Val Val Arg Arg Ser Lys 
            100                 105                 110         


Lys Val Ser Val Pro Ser Thr Val Ile Ser Arg Val Ile Gly Arg Gly 
        115                 120                 125             


Gly Cys Asn Ile Asn Ala Ile Arg Glu Phe Thr Gly Ala His Ile Asp 
    130                 135                 140                 


Ile Asp Lys Gln Lys Asp Lys Thr Gly Asp Arg Ile Ile Thr Ile Arg 
145                 150                 155                 160 


Gly Gly Thr Glu Ser Thr Arg Gln Ala Thr Gln Leu Ile Asn Ala Leu 
                165                 170                 175     


Ile Lys Asp Pro Asp Lys Glu Ile Asp Glu Leu Ile Pro Lys Asn Arg 
            180                 185                 190         


Leu Lys Ser Ser Ser Ala Asn Ser Lys Ile Gly Ser Ser Ala Pro Thr 
        195                 200                 205             


Thr Thr Ala Ala Asn Thr Ser Leu Met Gly Ile Lys Met Thr Thr Val 
    210                 215                 220                 


Ala Leu Ser Ser Thr Ser Gln Thr Ala Thr Ala Leu Thr Val Pro Ala 
225                 230                 235                 240 


Ile Ser Ser Ala Ser Thr His Lys Thr Ile Lys Asn Pro Val Asn Asn 
                245                 250                 255     


Val Arg Pro Gly Phe Pro Val Ser Leu Pro Leu Ala Tyr Pro Pro Pro 
            260                 265                 270         


Gln Phe Ala His Ala Leu Leu Ala Ala Gln Thr Phe Gln Gln Ile Arg 
        275                 280                 285             


Pro Pro Arg Leu Pro Met Thr His Phe Gly Gly Thr Phe Pro Pro Ala 
    290                 295                 300                 


Gln Ser Thr Trp Gly Pro Phe Pro Val Arg Pro Leu Ser Pro Ala Arg 
305                 310                 315                 320 


Ala Thr Asn Ser Pro Lys Pro His Met Val Pro Arg His Ser Asn Gln 
                325                 330                 335     


Asn Ser Ser Gly Ser Gln Val Asn Ser Ala Gly Ser Leu Thr Ser Ser 
            340                 345                 350         


Pro Thr Thr Thr Thr Ser Ser Ser Ala Ser Thr Val Pro Gly Thr Ser 
        355                 360                 365             


Thr Asn Gly Ser Pro Ser Ser Pro Ser Val Arg Arg Gln Leu Phe Val 
    370                 375                 380                 


Thr Val Val Lys Thr Ser Asn Ala Thr Thr Thr Thr Val Thr Thr Thr 
385                 390                 395                 400 


Ala Ser Asn Asn Asn Thr Ala Pro Thr Asn Ala Thr Tyr Pro Met Pro 
                405                 410                 415     


Thr Ala Lys Glu His Tyr Pro Val Ser Ser Pro Ser Ser Pro Ser Pro 
            420                 425                 430         


Pro Ala Gln Pro Gly Gly Val Ser Arg Asn Ser Pro Leu Asp Cys Gly 
        435                 440                 445             


Ser Ala Ser Pro Asn Lys Val Ala Ser Ser Ser Glu Gln Glu Ala Gly 
    450                 455                 460                 


Ser Pro Pro Val Val Glu Thr Thr Asn Thr Arg Pro Pro Asn Ser Ser 
465                 470                 475                 480 


Ser Ser Ser Gly Ser Ser Ser Ala His Ser Asn Gln Gln Gln Pro Pro 
                485                 490                 495     


Gly Ser Val Ser Gln Glu Pro Arg Pro Pro Leu Gln Gln Ser Gln Val 
            500                 505                 510         


Pro Pro Pro Glu Val Arg Met Thr Val Pro Pro Leu Ala Thr Ser Ser 
        515                 520                 525             


Ala Pro Val Ala Val Pro Ser Thr Ala Pro Val Thr Tyr Pro Met Pro 
    530                 535                 540                 


Gln Thr Pro Met Gly Cys Pro Gln Pro Thr Pro Lys Met Glu Thr Pro 
545                 550                 555                 560 


Ala Ile Arg Pro Pro Pro His Gly Thr Thr Ala Pro His Lys Asn Ser 
                565                 570                 575     


Ala Ser Val Gln Asn Ser Ser Val Ala Val Leu Ser Val Asn His Ile 
            580                 585                 590         


Lys Arg Pro His Ser Val Pro Ser Ser Val Gln Leu Pro Ser Thr Leu 
        595                 600                 605             


Ser Thr Gln Ser Ala Cys Gln Asn Ser Val His Pro Ala Asn Lys Pro 
    610                 615                 620                 


Ile Ala Pro Asn Phe Ser Ala Pro Leu Pro Phe Gly Pro Phe Ser Thr 
625                 630                 635                 640 


Leu Phe Glu Asn Ser Pro Thr Ser Ala His Ala Phe Trp Gly Gly Ser 
                645                 650                 655     


Val Val Ser Ser Gln Ser Thr Pro Glu Ser Met Leu Ser Gly Lys Ser 
            660                 665                 670         


Ser Tyr Leu Pro Asn Ser Asp Pro Leu His Gln Ser Asp Thr Ser Lys 
        675                 680                 685             


Ala Pro Gly Phe Arg Pro Pro Leu Gln Arg Pro Ala Pro Ser Pro Ser 
    690                 695                 700                 


Gly Ile Val Asn Met Asp Ser Pro Tyr Gly Ser Val Thr Pro Ser Ser 
705                 710                 715                 720 


Thr His Leu Gly Asn Phe Ala Ser Asn Ile Ser Gly Gly Gln Met Tyr 
                725                 730                 735     


Gly Pro Gly Ala Pro Leu Gly Gly Ala Pro Ala Ala Ala Asn Phe Asn 
            740                 745                 750         


Arg Gln His Phe Ser Pro Leu Ser Leu Leu Thr Pro Cys Ser Ser Ala 
        755                 760                 765             


Ser Asn Asp Ser Ser Ala Gln Ser Val Ser Ser Gly Val Arg Ala Pro 
    770                 775                 780                 


Ser Pro Ala Pro Ser Ser Val Pro Leu Gly Ser Glu Lys Pro Ser Asn 
785                 790                 795                 800 


Val Ser Gln Asp Ile Val Ala Ser Gly Pro Leu Lys Gly Leu Val Ala 
                805                 810                 815     


Ile Lys Thr Lys 
            820 


<210> 7545
<211> 2010
<212> PRT
<213> Homo sapiens

<400> 7545
Met Glu Lys Ala Thr Val Pro Val Ala Ala Ala Thr Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Thr Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Thr Ala Ser Lys Leu Leu Leu Ser Gly Thr Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Thr Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr 
                325                 330                 335     


Ala Leu Thr Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Thr Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp 
            420                 425                 430         


Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Thr Thr Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Thr Thr Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser 
    770                 775                 780                 


Ser Ser His Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Thr 
785                 790                 795                 800 


Asn Gln Ser Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Thr 
                805                 810                 815     


Glu Leu Glu Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu 
            820                 825                 830         


Gln Ser Leu Glu Leu Ala His Ala Asp Gln Leu Thr Lys Glu Lys Ile 
        835                 840                 845             


Glu Glu Leu Asn Lys Thr Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys 
    850                 855                 860                 


Ile Leu Glu Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Thr 
865                 870                 875                 880 


Gln Gln Gln Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile 
                885                 890                 895     


Gln Leu Gln Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu 
            900                 905                 910         


Thr Pro Val Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg 
        915                 920                 925             


Leu Gln Gln Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Thr 
    930                 935                 940                 


Ala Ala Gln Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln 
945                 950                 955                 960 


Ala Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn 
                965                 970                 975     


Leu Thr Glu Leu Gln Val Leu Ser Ser Leu Leu Gln Pro Cys Phe Leu 
            980                 985                 990         


Ser Thr Leu Pro Leu Ile Leu Met  His Arg Leu Arg Val  Ile Met Thr 
        995                 1000                 1005             


Arg Pro  Lys Ser Ser Ser Thr  Ser Glu Ser Gly Asp  Ser Asp Asn 
    1010                 1015                 1020             


Met Arg  Ile Ser Ser Cys Ser  Asp Glu Ser Ser Asn  Ser Asn Ser 
    1025                 1030                 1035             


Ser Arg  Lys Ser Asp Asn His  Ser Pro Ala Val Val  Thr Thr Thr 
    1040                 1045                 1050             


Val Ser  Ser Lys Lys Gln Pro  Ser Val Leu Val Thr  Phe Pro Lys 
    1055                 1060                 1065             


Glu Glu  Arg Lys Ser Val Ser  Gly Lys Ala Ser Ile  Lys Leu Ser 
    1070                 1075                 1080             


Glu Thr  Ile Ser Glu Gly Thr  Ser Asn Ser Leu Ser  Thr Cys Thr 
    1085                 1090                 1095             


Lys Ser  Gly Pro Ser Pro Leu  Ser Ser Pro Asn Gly  Lys Leu Thr 
    1100                 1105                 1110             


Val Ala  Ser Pro Lys Arg Gly  Gln Lys Arg Glu Glu  Gly Trp Lys 
    1115                 1120                 1125             


Glu Val  Val Arg Arg Ser Lys  Lys Val Ser Val Pro  Ser Thr Val 
    1130                 1135                 1140             


Ile Ser  Arg Val Ile Gly Arg  Gly Gly Cys Asn Ile  Asn Ala Ile 
    1145                 1150                 1155             


Arg Glu  Phe Thr Gly Ala His  Ile Asp Ile Asp Lys  Gln Lys Asp 
    1160                 1165                 1170             


Lys Thr  Gly Asp Arg Ile Ile  Thr Ile Arg Gly Gly  Thr Glu Ser 
    1175                 1180                 1185             


Thr Arg  Gln Ala Thr Gln Leu  Ile Asn Ala Leu Ile  Lys Asp Pro 
    1190                 1195                 1200             


Asp Lys  Glu Ile Asp Glu Leu  Ile Pro Lys Asn Arg  Leu Lys Ser 
    1205                 1210                 1215             


Ser Ser  Ala Asn Ser Lys Ile  Gly Ser Ser Ala Pro  Thr Thr Thr 
    1220                 1225                 1230             


Ala Ala  Asn Thr Ser Leu Met  Gly Ile Lys Met Thr  Thr Val Ala 
    1235                 1240                 1245             


Leu Ser  Ser Thr Ser Gln Thr  Ala Thr Ala Leu Thr  Val Pro Ala 
    1250                 1255                 1260             


Ile Ser  Ser Ala Ser Thr His  Lys Thr Ile Lys Asn  Pro Val Asn 
    1265                 1270                 1275             


Asn Val  Arg Pro Gly Phe Pro  Val Ser Leu Pro Leu  Ala Tyr Pro 
    1280                 1285                 1290             


Pro Pro  Gln Phe Ala His Ala  Leu Leu Ala Ala Gln  Thr Phe Gln 
    1295                 1300                 1305             


Gln Ile  Arg Pro Pro Arg Leu  Pro Met Thr His Phe  Gly Gly Thr 
    1310                 1315                 1320             


Phe Pro  Pro Ala Gln Ser Thr  Trp Gly Pro Phe Pro  Val Arg Pro 
    1325                 1330                 1335             


Leu Ser  Pro Ala Arg Ala Thr  Asn Ser Pro Lys Pro  His Met Val 
    1340                 1345                 1350             


Pro Arg  His Ser Asn Gln Asn  Ser Ser Gly Ser Gln  Val Asn Ser 
    1355                 1360                 1365             


Ala Gly  Ser Leu Thr Ser Ser  Pro Thr Thr Thr Thr  Ser Ser Ser 
    1370                 1375                 1380             


Ala Ser  Thr Val Pro Gly Thr  Ser Thr Asn Gly Ser  Pro Ser Ser 
    1385                 1390                 1395             


Pro Ser  Val Arg Arg Gln Leu  Phe Val Thr Val Val  Lys Thr Ser 
    1400                 1405                 1410             


Asn Ala  Thr Thr Thr Thr Val  Thr Thr Thr Ala Ser  Asn Asn Asn 
    1415                 1420                 1425             


Thr Ala  Pro Thr Asn Ala Thr  Tyr Pro Met Pro Thr  Ala Lys Glu 
    1430                 1435                 1440             


His Tyr  Pro Val Ser Ser Pro  Ser Ser Pro Ser Pro  Pro Ala Gln 
    1445                 1450                 1455             


Pro Gly  Gly Val Ser Arg Asn  Ser Pro Leu Asp Cys  Gly Ser Ala 
    1460                 1465                 1470             


Ser Pro  Asn Lys Val Ala Ser  Ser Ser Glu Gln Glu  Ala Gly Ser 
    1475                 1480                 1485             


Pro Pro  Val Val Glu Thr Thr  Asn Thr Arg Pro Pro  Asn Ser Ser 
    1490                 1495                 1500             


Ser Ser  Ser Gly Ser Ser Ser  Ala His Ser Asn Gln  Gln Gln Pro 
    1505                 1510                 1515             


Pro Gly  Ser Val Ser Gln Glu  Pro Arg Pro Pro Leu  Gln Gln Ser 
    1520                 1525                 1530             


Gln Val  Pro Pro Pro Glu Val  Arg Met Thr Val Pro  Pro Leu Ala 
    1535                 1540                 1545             


Thr Ser  Ser Ala Pro Val Ala  Val Pro Ser Thr Ala  Pro Val Thr 
    1550                 1555                 1560             


Tyr Pro  Met Pro Gln Thr Pro  Met Gly Cys Pro Gln  Pro Thr Pro 
    1565                 1570                 1575             


Lys Met  Glu Thr Pro Ala Ile  Arg Pro Pro Pro His  Gly Thr Thr 
    1580                 1585                 1590             


Ala Pro  His Lys Asn Ser Ala  Ser Val Gln Asn Ser  Ser Val Ala 
    1595                 1600                 1605             


Val Leu  Ser Val Asn His Ile  Lys Arg Pro His Ser  Val Pro Ser 
    1610                 1615                 1620             


Ser Val  Gln Leu Pro Ser Thr  Leu Ser Thr Gln Ser  Ala Cys Gln 
    1625                 1630                 1635             


Asn Ser  Val His Pro Ala Asn  Lys Pro Ile Ala Pro  Asn Phe Ser 
    1640                 1645                 1650             


Ala Pro  Leu Pro Phe Gly Pro  Phe Ser Thr Leu Phe  Glu Asn Ser 
    1655                 1660                 1665             


Pro Thr  Ser Ala His Ala Phe  Trp Gly Gly Ser Val  Val Ser Ser 
    1670                 1675                 1680             


Gln Ser  Thr Pro Glu Ser Met  Leu Ser Gly Lys Ser  Ser Tyr Leu 
    1685                 1690                 1695             


Pro Asn  Ser Asp Pro Leu His  Gln Ser Asp Thr Ser  Lys Ala Pro 
    1700                 1705                 1710             


Gly Phe  Arg Pro Pro Leu Gln  Arg Pro Ala Pro Ser  Pro Ser Gly 
    1715                 1720                 1725             


Ile Val  Asn Met Asp Ser Pro  Tyr Gly Ser Val Thr  Pro Ser Ser 
    1730                 1735                 1740             


Thr His  Leu Gly Asn Phe Ala  Ser Asn Ile Ser Gly  Gly Gln Met 
    1745                 1750                 1755             


Tyr Gly  Pro Gly Ala Pro Leu  Gly Gly Ala Pro Ala  Ala Ala Asn 
    1760                 1765                 1770             


Phe Asn  Arg Gln His Phe Ser  Pro Leu Ser Leu Leu  Thr Pro Cys 
    1775                 1780                 1785             


Ser Ser  Ala Ser Asn Asp Ser  Ser Ala Gln Ser Val  Ser Ser Gly 
    1790                 1795                 1800             


Val Arg  Ala Pro Ser Pro Ala  Pro Ser Ser Val Pro  Leu Gly Ser 
    1805                 1810                 1815             


Glu Lys  Pro Ser Asn Val Ser  Gln Asp Arg Lys Val  Pro Val Pro 
    1820                 1825                 1830             


Ile Gly  Thr Glu Arg Ser Ala  Arg Ile Arg Gln Thr  Gly Thr Ser 
    1835                 1840                 1845             


Ala Pro  Ser Val Ile Gly Ser  Asn Leu Ser Thr Ser  Val Gly His 
    1850                 1855                 1860             


Ser Gly  Ile Trp Ser Phe Glu  Gly Ile Gly Gly Asn  Gln Asp Lys 
    1865                 1870                 1875             


Val Asp  Trp Cys Asn Pro Gly  Met Gly Asn Pro Met  Ile His Arg 
    1880                 1885                 1890             


Pro Met  Ser Asp Pro Gly Val  Phe Ser Gln His Gln  Ala Met Glu 
    1895                 1900                 1905             


Arg Asp  Ser Thr Gly Ile Val  Thr Pro Ser Gly Thr  Phe His Gln 
    1910                 1915                 1920             


His Val  Pro Ala Gly Tyr Met  Asp Phe Pro Lys Val  Gly Gly Met 
    1925                 1930                 1935             


Pro Phe  Ser Val Tyr Gly Asn  Ala Met Ile Pro Pro  Val Ala Pro 
    1940                 1945                 1950             


Ile Pro  Asp Gly Ala Gly Gly  Pro Ile Phe Asn Gly  Pro His Ala 
    1955                 1960                 1965             


Ala Asp  Pro Ser Trp Asn Ser  Leu Ile Lys Met Val  Ser Ser Ser 
    1970                 1975                 1980             


Thr Glu  Asn Asn Gly Pro Gln  Thr Val Trp Thr Gly  Pro Trp Ala 
    1985                 1990                 1995             


Pro His  Met Asn Ser Val His  Met Asn Gln Leu Gly  
    2000                 2005                 2010 


<210> 7546
<211> 481
<212> PRT
<213> Homo sapiens

<400> 7546
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 7547
<211> 521
<212> PRT
<213> Homo sapiens

<400> 7547
Met Pro Ser Pro Gln Leu Leu Val Leu Phe Gly Ser Gln Thr Gly Thr 
1               5                   10                  15      


Ala Gln Asp Val Ser Glu Arg Leu Gly Arg Glu Ala Arg Arg Arg Arg 
            20                  25                  30          


Leu Gly Cys Arg Val Gln Ala Leu Asp Ser Tyr Pro Val Val Asn Leu 
        35                  40                  45              


Ile Asn Glu Pro Leu Val Ile Phe Val Cys Ala Thr Thr Gly Gln Gly 
    50                  55                  60                  


Asp Pro Pro Asp Asn Met Lys Asn Phe Trp Arg Phe Ile Phe Arg Lys 
65                  70                  75                  80  


Asn Leu Pro Ser Thr Ala Leu Cys Gln Met Asp Phe Ala Val Leu Gly 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Ala Lys Phe Asn Phe Val Ala Lys Lys Leu 
            100                 105                 110         


His Arg Arg Leu Leu Gln Leu Gly Gly Ser Ala Leu Leu Pro Val Cys 
        115                 120                 125             


Leu Gly Asp Asp Gln His Glu Leu Gly Leu Pro Ser Lys Phe Thr Leu 
    130                 135                 140                 


Leu Phe Leu Gln Glu Ala Pro Ser Thr Gly Ser Glu Gly Gln Arg Val 
145                 150                 155                 160 


Ala His Pro Gly Ser Gln Glu Pro Pro Ser Glu Ser Lys Pro Phe Leu 
                165                 170                 175     


Ala Pro Met Ile Ser Asn Gln Arg Val Thr Gly Pro Ser His Phe Gln 
            180                 185                 190         


Asp Val Arg Leu Ile Glu Phe Asp Ile Leu Gly Ser Gly Ile Ser Phe 
        195                 200                 205             


Ala Ala Gly Asp Val Val Leu Ile Gln Pro Ser Asn Ser Ala Ala His 
    210                 215                 220                 


Val Gln Arg Phe Cys Gln Val Leu Gly Leu Asp Pro Asp Gln Leu Phe 
225                 230                 235                 240 


Met Leu Gln Pro Arg Glu Pro Asp Val Ser Ser Pro Thr Arg Leu Pro 
                245                 250                 255     


Gln Pro Cys Ser Met Arg His Leu Val Ser His Tyr Leu Asp Ile Ala 
            260                 265                 270         


Ser Val Pro Arg Arg Ser Phe Phe Glu Leu Leu Ala Cys Leu Ser Leu 
        275                 280                 285             


His Glu Leu Glu Arg Glu Lys Leu Leu Glu Phe Ser Ser Ala Gln Gly 
    290                 295                 300                 


Gln Glu Glu Leu Phe Glu Tyr Cys Asn Arg Pro Arg Arg Thr Ile Leu 
305                 310                 315                 320 


Glu Val Leu Cys Asp Phe Pro His Thr Ala Ala Ala Ile Pro Pro Asp 
                325                 330                 335     


Tyr Leu Leu Asp Leu Ile Pro Val Ile Arg Pro Arg Ala Phe Ser Ile 
            340                 345                 350         


Ala Ser Ser Leu Leu Thr His Pro Ser Arg Leu Gln Ile Leu Val Ala 
        355                 360                 365             


Val Val Gln Phe Gln Thr Arg Leu Lys Glu Pro Arg Arg Gly Leu Cys 
    370                 375                 380                 


Ser Ser Trp Leu Ala Ser Leu Asp Pro Gly Gln Gly Pro Val Arg Val 
385                 390                 395                 400 


Pro Leu Trp Val Arg Pro Gly Ser Leu Ala Phe Pro Glu Thr Pro Asp 
                405                 410                 415     


Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            420                 425                 430         


Ala Ala Ile Gln Glu Arg Val Ala Gln Gly Gln Thr Gly Asn Phe Leu 
        435                 440                 445             


Phe Phe Gly Cys Arg Trp Arg Asp Gln Asp Phe Tyr Trp Glu Ala Glu 
    450                 455                 460                 


Trp Gln Glu Leu Glu Lys Arg Asp Cys Leu Thr Leu Ile Pro Ala Phe 
465                 470                 475                 480 


Ser Arg Glu Gln Glu Gln Lys Val Tyr Val Gln His Arg Leu Arg Glu 
                485                 490                 495     


Leu Gly Ser Leu Val Trp Glu Leu Leu Asp Arg Gln Ala Thr Pro Ser 
            500                 505                 510         


Pro Cys Gln Arg Thr Ser Arg Lys Pro 
        515                 520     


<210> 7548
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7548
Xaa Gln Pro Ser Pro Val Glu Pro Arg Gly Pro Phe Tyr Phe Cys Arg 
1               5                   10                  15      


Leu Leu Leu Asp Asp Leu Gly Met Asn Ser Trp Asp Arg Arg Lys Asn 
            20                  25                  30          


Phe His Leu Leu Lys Lys Asn Ser Lys Leu Leu Arg Glu Leu Lys Asn 
        35                  40                  45              


Leu Asp Ser Arg Gln Cys Arg Glu Thr His Lys Ile Ala Val Phe Tyr 
    50                  55                  60                  


Ile Ala Glu Gly Gln Glu Asp Lys Cys Ser Ile Leu Ser Asn Glu Arg 
65                  70                  75                  80  


Gly Ser Gln Ala Tyr Glu Asp Phe Val Ala Gly Leu Gly Trp Glu Val 
                85                  90                  95      


Asp Leu Ser Thr His Cys Gly Phe Met Gly Gly Leu Gln Arg Asn Gly 
            100                 105                 110         


Ser Thr Gly Gln Thr Ala Pro Tyr Tyr Ala Thr Ser Thr Val Glu Val 
        115                 120                 125             


Ile Phe His Val Ser Thr Arg Met Pro Ser Asp Ser Asp Asp Ser Leu 
    130                 135                 140                 


Thr Lys Lys Leu Arg His Leu Gly Asn Asp Glu Val His Ile Val Trp 
145                 150                 155                 160 


Ser Glu His Ser Arg Asp Tyr Arg Arg Gly Ile Ile Pro Thr Ala Phe 
                165                 170                 175     


Gly Asp Val Ser Ile Ile Ile Tyr Pro Met Lys Asn His Met Phe Phe 
            180                 185                 190         


Ile Ala Ile Thr Lys Lys Pro Glu Val Pro Phe Phe Gly Pro Leu Phe 
        195                 200                 205             


Asp Gly Ala Ile Val Ser Gly Lys Leu Leu Pro Ser Leu Val Cys Ala 
    210                 215                 220                 


Thr Cys Ile Asn Ala Ser Arg Ala Val Lys Cys Leu Ile Pro Leu Tyr 
225                 230                 235                 240 


Gln Ser Leu Tyr Leu Phe Ala Leu Asn Val 
                245                 250 


<210> 7549
<211> 114
<212> PRT
<213> Homo sapiens

<400> 7549
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala 
        


<210> 7550
<211> 609
<212> PRT
<213> Homo sapiens

<400> 7550
Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg 
1               5                   10                  15      


Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala 
            20                  25                  30          


Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu 
        35                  40                  45              


Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro 
    50                  55                  60                  


Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln 
65                  70                  75                  80  


Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu 
                85                  90                  95      


Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu 
            100                 105                 110         


Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His 
        115                 120                 125             


Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His 
    130                 135                 140                 


Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly 
                165                 170                 175     


Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro 
            180                 185                 190         


Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp 
        195                 200                 205             


Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala 
    210                 215                 220                 


Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile 
225                 230                 235                 240 


Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu 
                245                 250                 255     


Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly 
            260                 265                 270         


Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu 
        275                 280                 285             


Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile 
    290                 295                 300                 


Gln Asn Met Pro Asn Val Arg Asp His Asp Ala Ser Val Tyr Leu Arg 
305                 310                 315                 320 


Leu Gln Gly Asp Ala Leu Ser Val Gly Gly Tyr Glu Ala Asn Pro Ile 
                325                 330                 335     


Phe Trp Glu Glu Val Ser Asp Lys Phe Ala Phe Gly Leu Phe Asp Leu 
            340                 345                 350         


Asp Trp Glu Val Phe Thr Gln His Ile Glu Gly Ala Ile Asn Arg Val 
        355                 360                 365             


Pro Val Leu Glu Lys Thr Gly Ile Lys Ser Thr Val Cys Gly Pro Glu 
    370                 375                 380                 


Ser Phe Thr Pro Asp His Lys Pro Leu Met Gly Glu Ala Pro Glu Leu 
385                 390                 395                 400 


Arg Gly Phe Phe Leu Gly Cys Gly Phe Asn Ser Ala Gly Met Met Leu 
                405                 410                 415     


Gly Gly Gly Cys Gly Gln Glu Leu Ala His Trp Ile Ile His Gly Arg 
            420                 425                 430         


Pro Glu Lys Asp Met His Gly Tyr Asp Ile Arg Arg Phe His His Ser 
        435                 440                 445             


Leu Thr Asp His Pro Arg Trp Ile Arg Glu Arg Ser His Glu Ser Tyr 
    450                 455                 460                 


Ala Lys Asn Tyr Ser Val Val Phe Pro His Asp Glu Pro Leu Ala Gly 
465                 470                 475                 480 


Arg Asn Met Arg Arg Asp Pro Leu His Glu Glu Leu Leu Gly Gln Gly 
                485                 490                 495     


Cys Val Phe Gln Glu Arg His Gly Trp Glu Arg Pro Gly Trp Phe His 
            500                 505                 510         


Pro Arg Gly Pro Ala Pro Val Leu Glu Tyr Asp Tyr Tyr Gly Ala Tyr 
        515                 520                 525             


Gly Ser Arg Ala His Glu Asp Tyr Ala Tyr Arg Arg Leu Leu Ala Asp 
    530                 535                 540                 


Glu Tyr Thr Phe Ala Phe Pro Pro His His Asp Thr Ile Lys Lys Glu 
545                 550                 555                 560 


Cys Leu Ala Cys Arg Gly Ala Ala Ala Val Phe Asp Met Ser Tyr Phe 
                565                 570                 575     


Gly Lys Phe Tyr Leu Val Gly Leu Asp Ala Arg Lys Ala Ala Asp Trp 
            580                 585                 590         


Leu Phe Ser Ala Asp Val Ser Arg Pro Pro Gly Leu His Arg Val His 
        595                 600                 605             


Val 
    


<210> 7551
<211> 42
<212> PRT
<213> Homo sapiens

<400> 7551
Met Asp Asn Met Ser Pro Arg Leu Arg Ala Phe Leu Ser Glu Pro Ile 
1               5                   10                  15      


Gly Glu Lys Asp Val Cys Trp Val Asp Gly Ile Ser His Glu Leu Ala 
            20                  25                  30          


Ile Asn Leu Val Thr Lys Gly Ile Asn Lys 
        35                  40          


<210> 7552
<211> 1039
<212> PRT
<213> Homo sapiens

<400> 7552
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Met Ala 
        35                  40                  45              


Ser Leu Gln Val Phe Glu Lys Met His Arg Met Asp Leu Ser Glu Arg 
    50                  55                  60                  


Ala Lys Asp Glu Val Arg Glu Ala Ala Leu Lys Ser Phe Asn Lys Arg 
65                  70                  75                  80  


Lys Pro Leu Ser Leu Gly Ile Thr Arg Lys Glu Arg Pro Pro Leu Asp 
                85                  90                  95      


Val Asp Glu Met Leu Glu Arg Phe Lys Thr Glu Ala Gln Ala Phe Thr 
            100                 105                 110         


Glu Thr Lys Gly Asn Val Ile Cys Leu Gly Lys Glu Val Phe Lys Gly 
        115                 120                 125             


Lys Lys Pro Asp Lys Asp Asn Arg Cys Arg Tyr Ile Leu Lys Thr Lys 
    130                 135                 140                 


Phe Arg Glu Met Trp Lys Ser Trp Pro Gly Asp Ser Lys Glu Val Gln 
145                 150                 155                 160 


Val Met Ala Glu Arg Tyr Lys Met Leu Ile Pro Phe Ser Asn Pro Arg 
                165                 170                 175     


Val Leu Pro Gly Pro Phe Ser Tyr Thr Val Val Leu Tyr Gly Pro Ala 
            180                 185                 190         


Gly Leu Gly Lys Thr Thr Leu Ala Gln Lys Leu Met Leu Asp Trp Ala 
        195                 200                 205             


Glu Asp Asn Leu Ile His Lys Phe Lys Tyr Ala Phe Tyr Leu Ser Cys 
    210                 215                 220                 


Arg Glu Leu Ser Arg Leu Gly Pro Cys Ser Phe Ala Glu Leu Val Phe 
225                 230                 235                 240 


Arg Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro His Ile Leu Ala Gln 
                245                 250                 255     


Ala Arg Lys Ile Leu Phe Val Ile Asp Gly Phe Asp Glu Leu Gly Ala 
            260                 265                 270         


Ala Pro Gly Ala Leu Ile Glu Asp Ile Cys Gly Asp Trp Glu Lys Lys 
        275                 280                 285             


Lys Pro Val Pro Val Leu Leu Gly Ser Leu Leu Asn Arg Val Met Leu 
    290                 295                 300                 


Pro Lys Ala Ala Leu Leu Val Thr Thr Arg Pro Arg Ala Leu Arg Asp 
305                 310                 315                 320 


Leu Arg Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val Glu Gly Phe 
                325                 330                 335     


Leu Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His Phe Gly Asp Glu 
            340                 345                 350         


Asp Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser Asn Ala Ala Leu 
        355                 360                 365             


Phe Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile Val Cys Thr Thr 
    370                 375                 380                 


Leu Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val Pro Thr Cys Leu 
385                 390                 395                 400 


Thr Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser Arg Phe Pro Gln 
                405                 410                 415     


Gly Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser Leu Leu Ala Ala 
            420                 425                 430         


Gln Gly Leu Trp Ala Gln Thr Ser Val Leu His Arg Glu Asp Leu Glu 
        435                 440                 445             


Arg Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe Leu Asp Gly Asp 
    450                 455                 460                 


Ile Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr Ser Phe Ile His 
465                 470                 475                 480 


Leu Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr Thr Leu Glu Lys 
                485                 490                 495     


Glu Glu Glu Glu Asp Arg Asp Gly His Thr Trp Asp Ile Gly Asp Val 
            500                 505                 510         


Gln Lys Leu Leu Ser Gly Val Glu Arg Leu Arg Asn Pro Asp Leu Ile 
        515                 520                 525             


Gln Ala Gly Tyr Tyr Ser Phe Gly Leu Ala Asn Glu Lys Arg Ala Lys 
    530                 535                 540                 


Glu Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro Asp Ile Lys Gln 
545                 550                 555                 560 


Glu Leu Leu Arg Cys Asp Ile Ser Cys Lys Gly Gly His Ser Thr Val 
                565                 570                 575     


Thr Asp Leu Gln Glu Leu Leu Gly Cys Leu Tyr Glu Ser Gln Glu Glu 
            580                 585                 590         


Glu Leu Val Lys Glu Val Met Ala Gln Phe Lys Glu Ile Ser Leu His 
        595                 600                 605             


Leu Asn Ala Val Asp Val Val Pro Ser Ser Phe Cys Val Lys His Cys 
    610                 615                 620                 


Arg Asn Leu Gln Lys Met Ser Leu Gln Val Ile Lys Glu Asn Leu Pro 
625                 630                 635                 640 


Glu Asn Val Thr Ala Ser Glu Ser Asp Ala Glu Val Glu Arg Ser Gln 
                645                 650                 655     


Asp Asp Gln His Met Leu Pro Phe Trp Thr Asp Leu Cys Ser Ile Phe 
            660                 665                 670         


Gly Ser Asn Lys Asp Leu Met Gly Leu Ala Ile Asn Asp Ser Phe Leu 
        675                 680                 685             


Ser Ala Ser Leu Val Arg Ile Leu Cys Glu Gln Ile Ala Ser Asp Thr 
    690                 695                 700                 


Cys His Leu Gln Arg Val Val Phe Lys Asn Ile Ser Pro Ala Asp Ala 
705                 710                 715                 720 


His Arg Asn Leu Cys Leu Ala Leu Arg Gly His Lys Thr Val Thr Tyr 
                725                 730                 735     


Leu Thr Leu Gln Gly Asn Asp Gln Asp Asp Met Phe Pro Ala Leu Cys 
            740                 745                 750         


Glu Val Leu Arg His Pro Glu Cys Asn Leu Arg Tyr Leu Gly Leu Val 
        755                 760                 765             


Ser Cys Ser Ala Thr Thr Gln Gln Trp Ala Asp Leu Ser Leu Ala Leu 
    770                 775                 780                 


Glu Val Asn Gln Ser Leu Thr Cys Val Asn Leu Ser Asp Asn Glu Leu 
785                 790                 795                 800 


Leu Asp Glu Gly Ala Lys Leu Leu Tyr Thr Thr Leu Arg His Pro Lys 
                805                 810                 815     


Cys Phe Leu Gln Arg Leu Ser Leu Glu Asn Cys His Leu Thr Glu Ala 
            820                 825                 830         


Asn Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Arg Glu Leu Thr 
        835                 840                 845             


His Leu Cys Leu Ala Lys Asn Pro Ile Gly Asn Thr Gly Val Lys Phe 
    850                 855                 860                 


Leu Cys Glu Gly Leu Arg Tyr Pro Glu Cys Lys Leu Gln Thr Leu Val 
865                 870                 875                 880 


Leu Trp Asn Cys Asp Ile Thr Ser Asp Gly Cys Cys Asp Leu Thr Lys 
                885                 890                 895     


Leu Leu Gln Glu Lys Ser Ser Leu Leu Cys Leu Asp Leu Gly Leu Asn 
            900                 905                 910         


His Ile Gly Val Lys Gly Met Lys Phe Leu Cys Glu Ala Leu Arg Lys 
        915                 920                 925             


Pro Leu Cys Asn Leu Arg Cys Leu Trp Leu Trp Gly Cys Ser Ile Pro 
    930                 935                 940                 


Pro Phe Ser Cys Glu Asp Leu Cys Ser Ala Leu Ser Cys Asn Gln Ser 
945                 950                 955                 960 


Leu Val Thr Leu Asp Leu Gly Gln Asn Pro Leu Gly Ser Ser Gly Val 
                965                 970                 975     


Lys Met Leu Phe Glu Thr Leu Thr Cys Ser Ser Gly Thr Leu Arg Thr 
            980                 985                 990         


Leu Arg Leu Lys Ile Asp Asp Phe  Asn Asp Glu Leu Asn  Lys Leu Leu 
        995                 1000                 1005             


Glu Glu  Ile Glu Glu Lys Asn  Pro Gln Leu Ile Ile  Asp Thr Glu 
    1010                 1015                 1020             


Lys His  His Pro Trp Ala Glu  Arg Pro Ser Ser His  Asp Phe Met 
    1025                 1030                 1035             


Ile 
    


<210> 7553
<211> 632
<212> PRT
<213> Homo sapiens

<400> 7553
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                165                 170                 175     


Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
            180                 185                 190         


Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
        195                 200                 205             


Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
    210                 215                 220                 


Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
225                 230                 235                 240 


Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                245                 250                 255     


Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
            260                 265                 270         


Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
        275                 280                 285             


Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys Gly 
    290                 295                 300                 


Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys Arg 
305                 310                 315                 320 


Val Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys Ile 
                325                 330                 335     


Pro Thr Leu Ile Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu Ala 
            340                 345                 350         


Asp Phe Val Ser Gln Thr Ser Pro Met Ile Pro Ser Ile Val Val His 
        355                 360                 365             


Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Thr Gly Leu Tyr 
    370                 375                 380                 


Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys Phe 
385                 390                 395                 400 


Leu Arg Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile His 
                405                 410                 415     


Ala Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu Pro 
            420                 425                 430         


Leu Leu Thr Phe Arg Leu Asn Arg Ala Phe Met Glu Ala Ala Glu Ile 
        435                 440                 445             


Thr Asp Glu Asp Asn Ser Ile Ala Ala Met Tyr Gln Ala Val Gly Glu 
    450                 455                 460                 


Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His Leu 
465                 470                 475                 480 


Gln Arg Val Ala Gln Ser Pro His Thr Lys Met Asp Val Ala Asn Leu 
                485                 490                 495     


Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Ala Val Pro Asn Pro 
            500                 505                 510         


Asp Pro Val Thr Met Leu Gln Asp Ile Lys Arg Gln Pro Lys Val Val 
        515                 520                 525             


Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Ser Gln Phe Met Met 
    530                 535                 540                 


Val Glu Gln Glu Asn Ile Asp Pro Leu His Val Ile Glu Asn Ser Asn 
545                 550                 555                 560 


Ala Phe Ser Thr Pro Gln Thr Pro Asp Ile Lys Val Ser Leu Leu Gly 
                565                 570                 575     


Pro Val Thr Thr Pro Glu His Gln Leu Leu Lys Thr Pro Ser Ser Ser 
            580                 585                 590         


Ser Leu Ser Gln Arg Val Arg Ser Thr Leu Thr Lys Asn Thr Pro Arg 
        595                 600                 605             


Phe Gly Ser Lys Ser Lys Ser Ala Thr Asn Leu Gly Arg Gln Gly Asn 
    610                 615                 620                 


Phe Phe Ala Ser Pro Met Leu Lys 
625                 630         


<210> 7554
<211> 62
<212> PRT
<213> Homo sapiens

<400> 7554
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala 
    50                  55                  60          


<210> 7555
<211> 138
<212> PRT
<213> Homo sapiens

<400> 7555
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Thr Thr Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Thr Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro Pro Ser Phe Asn Leu His 
            100                 105                 110         


Pro Ala Pro His Leu Leu Ala Ser Met His Leu Gln Lys Leu Asn Ser 
        115                 120                 125             


Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro 
    130                 135             


<210> 7556
<211> 490
<212> PRT
<213> Homo sapiens

<400> 7556
Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu 
            20                  25                  30          


Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu 
        195                 200                 205             


Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly 
225                 230                 235                 240 


Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu 
                245                 250                 255     


Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser 
            260                 265                 270         


Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu 
        275                 280                 285             


Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala 
    290                 295                 300                 


Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Val Ala 
                325                 330                 335     


Gln Met Leu Ser Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr 
            340                 345                 350         


Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala 
        355                 360                 365             


Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr 
    370                 375                 380                 


Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu 
385                 390                 395                 400 


Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe 
                405                 410                 415     


Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile 
            420                 425                 430         


Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe 
        435                 440                 445             


Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln 
    450                 455                 460                 


Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu 
465                 470                 475                 480 


Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
                485                 490 


<210> 7557
<211> 118
<212> PRT
<213> Homo sapiens

<400> 7557
Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys 
        115             


<210> 7558
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7558
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7559
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7559
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 7560
<211> 302
<212> PRT
<213> Homo sapiens

<400> 7560
Met Val Thr Glu Gln Glu Val Asp Ala Ile Gly Gln Thr Leu Val Asp 
1               5                   10                  15      


Pro Lys Gln Pro Leu Gln Ala Arg Phe Arg Ala Leu Phe Thr Leu Arg 
            20                  25                  30          


Gly Leu Gly Gly Pro Gly Ala Ile Ala Trp Ile Ser Gln Ala Phe Asp 
        35                  40                  45              


Asp Asp Ser Ala Leu Leu Lys His Glu Leu Ala Tyr Cys Leu Gly Gln 
    50                  55                  60                  


Met Gln Asp Ala Arg Ala Ile Pro Met Leu Val Asp Val Leu Gln Asp 
65                  70                  75                  80  


Thr Arg Gln Glu Pro Met Val Arg His Glu Ala Gly Glu Ala Leu Gly 
                85                  90                  95      


Ala Ile Gly Asp Pro Glu Val Leu Glu Ile Leu Lys Gln Tyr Ser Ser 
            100                 105                 110         


Asp Pro Val Ile Glu Val Ala Glu Thr Cys Gln Leu Ala Val Arg Arg 
        115                 120                 125             


Leu Glu Trp Leu Gln Gln His Gly Gly Glu Pro Ala Ala Gly Pro Tyr 
    130                 135                 140                 


Leu Ser Val Asp Pro Ala Pro Pro Ala Glu Glu Arg Asp Val Gly Arg 
145                 150                 155                 160 


Leu Arg Glu Ala Leu Leu Asp Glu Ser Arg Pro Leu Phe Glu Arg Tyr 
                165                 170                 175     


Arg Ala Met Phe Ala Leu Arg Asn Ala Gly Gly Glu Glu Ala Ala Leu 
            180                 185                 190         


Ala Leu Ala Glu Gly Leu His Cys Gly Ser Ala Leu Phe Arg His Glu 
        195                 200                 205             


Val Gly Tyr Val Leu Gly Gln Leu Gln His Glu Ala Ala Val Pro Gln 
    210                 215                 220                 


Leu Ala Ala Ala Leu Ala Arg Cys Thr Glu Asn Pro Met Val Arg His 
225                 230                 235                 240 


Glu Cys Ala Glu Ala Leu Gly Ala Ile Ala Arg Pro Ala Cys Leu Ala 
                245                 250                 255     


Ala Leu Gln Ala His Ala Asp Asp Pro Glu Arg Val Val Arg Glu Ser 
            260                 265                 270         


Cys Glu Val Ala Leu Asp Met Tyr Glu His Glu Thr Gly Arg Ala Phe 
        275                 280                 285             


Gln Tyr Ala Asp Gly Leu Glu Gln Leu Arg Gly Ala Pro Ser 
    290                 295                 300         


<210> 7561
<211> 506
<212> PRT
<213> Homo sapiens

<400> 7561
Met Ser Val Leu Ser Pro Gly Asp Leu Lys Pro Lys Arg Gly Ser Pro 
1               5                   10                  15      


His Arg Gly Ser Leu Asp Arg Thr Asp Ala Ser Thr Asp Leu Ala Met 
            20                  25                  30          


Arg Ser Trp Pro Ser Glu Leu Gly Ser Arg Thr Cys Ser Thr Ser Ala 
        35                  40                  45              


Thr Thr Thr Ala Pro Ser Asn Ser Thr Pro Ile Ala Arg His Pro Gly 
    50                  55                  60                  


Arg Thr Lys Gly Tyr Asn Ser Asp Asp Asn Leu Cys Glu Pro Ser Leu 
65                  70                  75                  80  


Glu Phe Glu Val Pro Asn His Arg Gln Tyr Val Ser Arg Pro Ser Ser 
                85                  90                  95      


Leu Glu Ser Ser Arg Asn Thr Ser Ser Asn Ser Ser Pro Leu Asn Leu 
            100                 105                 110         


Lys Gly Ser Ser Glu Gln Leu His Gly Arg Ser Glu Ser Phe Ser Ser 
        115                 120                 125             


Glu Asp Leu Ile Pro Ser Arg Asp Leu Ala Thr Leu Pro Arg Glu Ala 
    130                 135                 140                 


Ser Thr Pro Gly Arg Asn Ala Leu Gly Arg His Glu Tyr Pro Leu Pro 
145                 150                 155                 160 


Arg Asn Gly Pro Leu Pro Gln Glu Gly Ala Gln Lys Arg Gly Thr Ala 
                165                 170                 175     


Pro Pro Tyr Val Gly Val Arg Pro Cys Ser Ala Ser Pro Ser Ser Glu 
            180                 185                 190         


Met Val Thr Leu Glu Glu Phe Leu Glu Glu Ser Asn Arg Ser Ser Pro 
        195                 200                 205             


Thr His Asp Thr Pro Ser Cys Arg Asp Asp Leu Leu Ser Asp Tyr Phe 
    210                 215                 220                 


Arg Lys Ala Ser Asp Pro Pro Ala Ile Gly Gly Gln Pro Gly Pro Pro 
225                 230                 235                 240 


Ala Lys Lys Glu Gly Ala Lys Met Pro Thr Asn Phe Val Ala Pro Thr 
                245                 250                 255     


Val Lys Met Ala Ala Pro Thr Ser Glu Gly Arg Pro Leu Lys Pro Gly 
            260                 265                 270         


Gln Tyr Val Lys Pro Asn Phe Arg Leu Thr Glu Ala Glu Ala Pro Pro 
        275                 280                 285             


Ser Val Ala Pro Arg Gln Ala Gln Pro Pro Gln Ser Leu Ser Leu Gly 
    290                 295                 300                 


Arg Pro Arg Gln Ala Pro Glu Ala Leu Gly Gly Arg Glu Thr Gly Ser 
305                 310                 315                 320 


His Thr Leu Gln Ser Pro Ala Pro Pro Ser Ser His Ser Leu Ala Arg 
                325                 330                 335     


Glu Arg Thr Pro Leu Val Gly Lys Ala Gly Ser Ser Cys Gln Gly Pro 
            340                 345                 350         


Gly Pro Arg Ser Arg Pro Leu Asp Thr Arg Arg Phe Ser Leu Ala Pro 
        355                 360                 365             


Pro Lys Glu Glu Arg Leu Ala Pro Leu His Gln Ser Ala Thr Ala Pro 
    370                 375                 380                 


Ala Ile Ala Thr Ala Gly Ala Gly Ala Ala Ala Ala Gly Ser Gly Ser 
385                 390                 395                 400 


Asn Ser Gln Leu Leu His Phe Ser Pro Ala Ala Ala Pro Ala Ala Arg 
                405                 410                 415     


Thr Lys Pro Lys Ala Pro Pro Arg Ser Gly Glu Val Ala Thr Ile Thr 
            420                 425                 430         


Pro Val Arg Ala Gly Leu Ser Leu Ser Glu Gly Asp Gly Val Pro Gly 
        435                 440                 445             


Gln Gly Cys Ser Glu Gly Leu Pro Ala Lys Ser Pro Gly Arg Ser Pro 
    450                 455                 460                 


Asp Leu Ala Pro His Leu Gly Arg Ala Leu Glu Asp Cys Ser Arg Gly 
465                 470                 475                 480 


Ser Val Ser Lys Ser Ser Pro Ala Ser Pro Glu Pro Gly Gly Asp Pro 
                485                 490                 495     


Gln Thr Val Trp Tyr Glu Tyr Gly Cys Val 
            500                 505     


<210> 7562
<211> 225
<212> PRT
<213> Homo sapiens

<400> 7562
Met Ala Gln Thr Val Pro Pro Cys Glu Leu Pro Cys Lys Glu Tyr Asp 
1               5                   10                  15      


Val Ala Arg Asn Thr Gly Ala Tyr Thr Ser Ser Gly Leu Ala Thr Ala 
            20                  25                  30          


Ser Phe Arg Thr Ser Lys Tyr Leu Leu Glu Glu Trp Phe Gln Asn Cys 
        35                  40                  45              


Tyr Ala Arg Tyr His Gln Ala Phe Ala Asp Arg Asp Gln Ser Glu Arg 
    50                  55                  60                  


Gln Arg His Glu Ser Gln Gln Leu Ala Thr Glu Thr Gln Ala Leu Ala 
65                  70                  75                  80  


Gln Arg Thr Gln Gln Asp Ser Thr Arg Thr Val Gly Glu Arg Leu Gln 
                85                  90                  95      


Asp Thr His Ser Trp Lys Ser Glu Leu Gln Arg Glu Met Glu Ala Leu 
            100                 105                 110         


Ala Ala Glu Thr Asn Leu Leu Leu Ala Gln Lys Gln Arg Leu Glu Arg 
        115                 120                 125             


Ala Leu Asp Ala Thr Glu Val Pro Phe Ser Ile Thr Thr Asp Asn Leu 
    130                 135                 140                 


Gln Cys Arg Glu Arg Arg Glu His Pro Asn Leu Val Arg Asp His Val 
145                 150                 155                 160 


Glu Thr Glu Leu Leu Lys Ala Leu Pro Pro Ala Leu Ser Gln Cys Leu 
                165                 170                 175     


Lys Asn Ser Cys Ser Ser Arg Lys Leu Ser Ala Arg Asn Lys Gly Thr 
            180                 185                 190         


Cys Gln Leu Met Glu Thr Leu Thr Val His Gly Glu Ala Asn Pro Gly 
        195                 200                 205             


Ile Glu Gly Arg Arg Thr Arg Ala Leu Ala His Lys Glu Val Pro Ser 
    210                 215                 220                 


Gly 
225 


<210> 7563
<211> 102
<212> PRT
<213> Homo sapiens

<400> 7563
Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp 
            100         


<210> 7564
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7564
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7565
<211> 103
<212> PRT
<213> Homo sapiens

<400> 7565
Met Ser Gly Gly Leu Leu Lys Ala Leu Arg Ser Asp Ser Tyr Val Glu 
1               5                   10                  15      


Leu Ser Gln Tyr Arg Asp Gln His Phe Arg Gly Asp Asn Glu Glu Gln 
            20                  25                  30          


Glu Lys Leu Leu Lys Lys Ser Tyr Ala Glu Asn Ala Met Arg Tyr Ile 
        35                  40                  45              


Asn Gly Thr Arg Leu Asp Asp Arg Ile Ile Arg Thr Asp Trp Asp Ala 
    50                  55                  60                  


Gly Phe Lys Glu Gly Arg Gln Tyr Gly Arg Gly Arg Ser Gly Gly Gln 
65                  70                  75                  80  


Val Arg Asp Glu Tyr Arg Gln Asp Tyr Asp Ala Gly Arg Gly Gly Tyr 
                85                  90                  95      


Gly Lys Leu Ala Gln Asn Gln 
            100             


<210> 7566
<211> 297
<212> PRT
<213> Homo sapiens

<400> 7566
Met Trp Pro Phe Pro Ser Arg Ser Leu Phe Pro Pro Pro Thr Gln Ala 
1               5                   10                  15      


Trp Leu Gln Thr Val Ser Ser Asp Pro Glu Ala Gln Gly Trp Gly Ala 
            20                  25                  30          


Trp Asn Glu Thr Lys Glu Ile Leu Gly Pro Glu Gly Gly Glu Gly Lys 
        35                  40                  45              


Glu Glu Lys Glu Glu Glu Glu Asp Ala Glu Glu Asp Gln Asp Gly Asp 
    50                  55                  60                  


Ala Gly Phe Leu Leu Ser Leu Leu Glu Gln Glu Asn Leu Ala Glu Cys 
65                  70                  75                  80  


Pro Leu Pro Asp Gln Glu Leu Glu Ala Ile Lys Met Lys Val Cys Ala 
                85                  90                  95      


Met Glu Gln Ala Glu Gly Thr Pro Arg Pro Pro Gly Val Gln Gln Gln 
            100                 105                 110         


Ala Glu Glu Glu Glu Gly Thr Ala Ala Gly Gln Leu Leu Ser Pro Glu 
        115                 120                 125             


Thr Val Gly Cys Pro Leu Ser Gly Thr Pro Glu Glu Lys Val Glu Ala 
    130                 135                 140                 


Asp His Arg Ser Val Tyr Val Gly Asn Leu Cys Leu His Arg Val Cys 
145                 150                 155                 160 


His Gln Gly Leu Arg Ala Gly Arg Arg Gly Ala Gly Pro Glu Pro Leu 
                165                 170                 175     


Pro Gly Pro Gly His Gln Gly Ala Ala Glu Lys Asn Gln Leu Pro Trp 
            180                 185                 190         


Asp Gln Leu His Arg Pro Arg Gly Pro Ser Arg Thr Pro Arg Leu Gln 
        195                 200                 205             


Gly Gly Thr Leu Pro Pro Gln Arg Pro Pro Gly Gln Ala Pro Ala Gln 
    210                 215                 220                 


Thr Thr Arg Ala Glu Pro Gly Pro Trp Lys Ile Leu Thr Met Val Phe 
225                 230                 235                 240 


Thr Val Leu Lys Gly Arg Pro Asp Phe Glu Arg Gly Ala Gly Ala Trp 
                245                 250                 255     


Ile Arg Ser Lys Pro Leu Val Leu His Pro Gly Ala Gly Ala Gly Ser 
            260                 265                 270         


Gly Ala Gly Ala Arg Pro Glu Glu Arg Gly Val Gln Ser Ser His Trp 
        275                 280                 285             


Pro Pro Leu Gly Gly Gly Met Ala Gln 
    290                 295         


<210> 7567
<211> 352
<212> PRT
<213> Homo sapiens

<400> 7567
Met Asp Ile Asp Lys Asp Leu Glu Ala Pro Leu Tyr Leu Thr Pro Glu 
1               5                   10                  15      


Gly Trp Ser Leu Phe Leu Gln Arg Tyr Tyr Gln Val Val His Glu Gly 
            20                  25                  30          


Ala Glu Leu Arg His Leu Asp Thr Gln Val Gln Arg Cys Glu Asp Ile 
        35                  40                  45              


Leu Gln Gln Leu Gln Ala Val Val Pro Gln Ile Asp Met Glu Gly Asp 
    50                  55                  60                  


Arg Asn Ile Trp Ile Val Lys Pro Gly Ala Lys Ser Arg Gly Arg Gly 
65                  70                  75                  80  


Ile Met Cys Met Asp His Leu Glu Glu Met Leu Lys Leu Val Asn Gly 
                85                  90                  95      


Asn Pro Val Val Met Lys Asp Gly Lys Trp Val Val Gln Lys Tyr Ile 
            100                 105                 110         


Glu Arg Pro Leu Leu Ile Phe Gly Thr Lys Phe Asp Leu Arg Gln Trp 
        115                 120                 125             


Phe Leu Val Thr Asp Trp Asn Pro Leu Thr Val Trp Phe Tyr Arg Asp 
    130                 135                 140                 


Ser Tyr Ile Arg Phe Ser Thr Gln Pro Phe Ser Leu Lys Asn Leu Asp 
145                 150                 155                 160 


Asn Ser Val His Leu Cys Asn Asn Ser Ile Gln Lys His Leu Glu Asn 
                165                 170                 175     


Ser Cys His Arg His Pro Leu Leu Pro Pro Asp Asn Met Trp Ser Ser 
            180                 185                 190         


Gln Arg Phe Gln Ala His Leu Gln Glu Met Gly Ala Pro Asn Ala Trp 
        195                 200                 205             


Ser Thr Ile Ile Val Pro Gly Met Lys Asp Ala Val Ile His Ala Leu 
    210                 215                 220                 


Gln Thr Ser Gln Asp Thr Val Gln Cys Arg Lys Ala Ser Phe Glu Leu 
225                 230                 235                 240 


Tyr Gly Ala Asp Phe Val Phe Gly Glu Asp Phe Gln Pro Trp Leu Ile 
                245                 250                 255     


Glu Ile Asn Ala Ser Pro Thr Met Ala Pro Ser Thr Ala Val Thr Ala 
            260                 265                 270         


Arg Leu Cys Ala Gly Val Gln Ala Asp Thr Leu Arg Val Val Ile Asp 
        275                 280                 285             


Arg Met Leu Asp Arg Asn Cys Asp Thr Gly Ala Phe Glu Leu Ile Tyr 
    290                 295                 300                 


Lys Gln Pro Val Thr Thr Ser Pro Ala Ser Thr Pro Arg Pro Ser Cys 
305                 310                 315                 320 


Leu Leu Pro Met Tyr Ser Asp Thr Arg Ala Arg Ser Ser Asp Asp Ser 
                325                 330                 335     


Thr Ala Ser Trp Trp Ala Leu Arg Pro Cys Arg Pro Gln Ala Arg Pro 
            340                 345                 350         


<210> 7568
<211> 120
<212> PRT
<213> Homo sapiens

<400> 7568
Met Glu Leu Asp Leu Phe Leu Gly Leu Asp Asp Val Phe Pro Arg Leu 
1               5                   10                  15      


Leu His Gly Leu Leu His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr 
            20                  25                  30          


Glu Asn Lys Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe 
        35                  40                  45              


Pro Gly Cys Phe Thr Asn Thr Cys Cys Ser His Pro Leu Ser Asn Pro 
    50                  55                  60                  


Ala Glu Leu Glu Glu Ser Asp Ala Leu Gly Val Arg Arg Ala Ala Gln 
65                  70                  75                  80  


Arg Arg Leu Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu Val Thr Ser 
                85                  90                  95      


Ser Pro Thr Gln Pro Tyr Lys Leu Lys Pro Lys His Thr Ile Lys Arg 
            100                 105                 110         


Phe Leu Ile Lys Phe Leu Asn Ser 
        115                 120 


<210> 7569
<211> 112
<212> PRT
<213> Homo sapiens

<400> 7569
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Phe Pro 
        35                  40                  45              


Ile Ser Lys Pro Asp Gly Ile Ser Gln Leu Glu Gln Asp Leu Gln Val 
    50                  55                  60                  


Phe Asp Leu Glu Thr Lys Thr Arg Glu Val Leu Arg Asp Asp Cys Ser 
65                  70                  75                  80  


Asp Gly Glu Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys 
                85                  90                  95      


Ile Ser Glu Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys 
            100                 105                 110         


<210> 7570
<211> 605
<212> PRT
<213> Homo sapiens

<400> 7570
Met Ser Glu Ile Leu Lys Gln Lys Asp Thr Glu Pro Thr Asn Phe Lys 
1               5                   10                  15      


Val Ala Ala Gly Thr Leu Asp Ala Ser Thr Lys Ile Tyr Ala Val Arg 
            20                  25                  30          


Val Asp Ala Val His Ala Asp Val Tyr Arg Val Leu Gly Gly Leu Gly 
        35                  40                  45              


Lys Asp Ala Pro Ser Leu Glu Glu Val Glu Gly His Val Ala Asp Gly 
    50                  55                  60                  


Ser Ala Thr Glu Met Gly Thr Thr Lys Lys Ala Val Lys Pro Lys Lys 
65                  70                  75                  80  


Lys His Leu His Arg Thr Ile Glu Gln Asn Ile Asn Asn Leu Asn Val 
                85                  90                  95      


Ser Glu Ala Asp Arg Lys Cys Glu Ile Asp Pro Met Phe Gln Lys Thr 
            100                 105                 110         


Ala Ala Ser Phe Asp Glu Cys Ser Thr Ala Gly Val Phe Leu Ser Thr 
        115                 120                 125             


Leu His Cys Gln Asp Tyr Arg Ser Glu Leu Leu Phe Pro Ser Asp Val 
    130                 135                 140                 


Gln Thr Leu Ser Thr Gly Glu Pro Leu Glu Leu Pro Glu Leu Gly Cys 
145                 150                 155                 160 


Val Glu Met Thr Asp Leu Lys Ala Pro Leu Gln Gln Cys Ala Glu Asp 
                165                 170                 175     


Arg Gln Ile Cys Pro Ser Leu Ala Gly Phe Gln Phe Thr Gln Trp Asp 
            180                 185                 190         


Ser Glu Thr His Asn Glu Ser Val Ser Ala Leu Val Asp Lys Phe Lys 
        195                 200                 205             


Lys Asn Asp Gln Val Phe Asp Ile Asn Ala Glu Val Asp Glu Ser Asp 
    210                 215                 220                 


Cys Gly Asp Phe Pro Asp Gly Ser Leu Gly Asp Asp Phe Asp Ala Asn 
225                 230                 235                 240 


Asp Glu Pro Asp His Thr Ala Val Gly Asp His Glu Glu Phe Arg Ser 
                245                 250                 255     


Trp Lys Glu Pro Cys Gln Val Gln Ser Cys Gln Glu Glu Met Ile Ser 
            260                 265                 270         


Leu Gly Asp Gly Asp Ile Arg Thr Met Cys Pro Leu Leu Ser Met Lys 
        275                 280                 285             


Pro Gly Glu Tyr Ser Tyr Phe Ser Pro Arg Thr Met Ser Met Trp Ala 
    290                 295                 300                 


Gly Pro Asp His Trp Arg Phe Arg Pro Arg Arg Lys Gln Asp Ala Pro 
305                 310                 315                 320 


Ser Gln Ser Glu Asn Lys Lys Lys Ser Thr Lys Lys Asp Phe Glu Ile 
                325                 330                 335     


Asp Phe Glu Asp Asp Ile Asp Phe Asp Val Tyr Phe Arg Lys Thr Lys 
            340                 345                 350         


Ala Ala Thr Ile Leu Thr Lys Ser Thr Leu Glu Asn Gln Asn Trp Arg 
        355                 360                 365             


Ala Thr Thr Leu Pro Thr Asp Phe Asn Tyr Asn Val Asp Thr Leu Val 
    370                 375                 380                 


Gln Leu His Leu Lys Pro Gly Thr Arg Leu Leu Lys Met Ala Gln Gly 
385                 390                 395                 400 


His Arg Val Glu Thr Glu His Tyr Glu Glu Ile Glu Asp Tyr Asp Tyr 
                405                 410                 415     


Asn Asn Pro Asn Asp Thr Ser Asn Phe Cys Pro Gly Leu Gln Ala Ala 
            420                 425                 430         


Asp Ser Asp Asp Glu Asp Leu Asp Asp Leu Phe Val Gly Pro Val Gly 
        435                 440                 445             


Asn Ser Asp Leu Ser Pro Tyr Pro Cys His Pro Pro Lys Thr Ala Gln 
    450                 455                 460                 


Gln Asn Gly Asp Thr Pro Glu Ala Gln Gly Leu Asp Ile Thr Thr Tyr 
465                 470                 475                 480 


Gly Glu Ser Asn Leu Val Ala Glu Pro Gln Lys Val Asn Lys Ile Glu 
                485                 490                 495     


Ile His Tyr Ala Lys Thr Ala Lys Lys Met Asp Met Lys Lys Leu Lys 
            500                 505                 510         


Gln Ser Met Trp Ser Leu Leu Thr Ala Leu Ser Gly Lys Glu Ala Asp 
        515                 520                 525             


Ala Glu Ala Asn His Arg Glu Ala Gly Lys Glu Ala Ala Leu Ala Glu 
    530                 535                 540                 


Val Ala Asp Glu Lys Met Leu Ser Gly Leu Thr Lys Asp Leu Gln Arg 
545                 550                 555                 560 


Ser Leu Pro Pro Val Met Ala Gln Asn Leu Ser Ile Pro Leu Ala Phe 
                565                 570                 575     


Ala Cys Leu Leu His Leu Ala Asn Glu Lys Asn Leu Lys Leu Glu Gly 
            580                 585                 590         


Thr Glu Asp Leu Ser Asp Val Leu Val Arg Gln Gly Asp 
        595                 600                 605 


<210> 7571
<211> 750
<212> PRT
<213> Homo sapiens

<400> 7571
Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15      


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30          


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45              


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Asp Asp Gln Gly Phe Gln 
    50                  55                  60                  


Glu Gly Glu Asp Glu Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu 
65                  70                  75                  80  


Asn Gly His Gly Glu Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln 
                85                  90                  95      


Gln Pro Gln Gln Gln Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser 
            100                 105                 110         


Ser Gly Pro Thr Ser Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala 
        115                 120                 125             


Arg Gln Gly Gln Gln Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Arg Pro Gly Ala Pro Ala Ala Gly Asp Gly Lys Thr 
145                 150                 155                 160 


Glu Gln Lys Gly Gly Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu 
                165                 170                 175     


Asp His Gly Arg Gly Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser 
            180                 185                 190         


Arg Ala Lys Ser Pro Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe 
        195                 200                 205             


Asp Asp Thr Val Val Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe 
    210                 215                 220                 


Lys Ile Ser Arg Asp Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser 
225                 230                 235                 240 


Phe Ala Phe Leu Trp Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys 
                245                 250                 255     


Gly Lys Val Cys Phe Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg 
            260                 265                 270         


His Leu Tyr Thr Lys Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp 
        275                 280                 285             


Ser Leu Thr Thr Ser Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr 
    290                 295                 300                 


Gly Tyr Ser Leu Lys Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp 
305                 310                 315                 320 


Tyr Gly Glu Lys Phe Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn 
                325                 330                 335     


Phe Glu Ser Asp Glu Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp 
            340                 345                 350         


Leu Gly Val Ala Phe Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro 
        355                 360                 365             


Leu Phe Pro His Val Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe 
    370                 375                 380                 


Gly Gln Lys Glu Lys Pro Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe 
385                 390                 395                 400 


Ile Gln Asn Val Pro Leu Glu Asp Arg Val Arg Gly Pro Lys Gly Pro 
                405                 410                 415     


Glu Glu Lys Lys Asp Cys Glu Val Val Met Met Ile Gly Leu Pro Gly 
            420                 425                 430         


Ala Gly Lys Thr Thr Trp Val Thr Lys His Ala Ala Glu Asn Pro Gly 
        435                 440                 445             


Lys Tyr Asn Ile Leu Gly Thr Asn Thr Ile Met Asp Lys Met Met Val 
    450                 455                 460                 


Ala Gly Phe Lys Lys Gln Met Ala Asp Thr Gly Lys Leu Asn Thr Leu 
465                 470                 475                 480 


Leu Gln Arg Ala Pro Gln Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala 
                485                 490                 495     


Arg Lys Lys Arg Asn Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala 
            500                 505                 510         


Ala Gln Arg Arg Lys Met Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala 
        515                 520                 525             


Val Val Val Cys Pro Lys Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys 
    530                 535                 540                 


Lys Ala Glu Val Glu Gly Lys Asp Leu Pro Glu His Ala Val Leu Lys 
545                 550                 555                 560 


Met Lys Gly Asn Phe Thr Leu Pro Glu Val Ala Glu Cys Phe Asp Glu 
                565                 570                 575     


Ile Thr Tyr Val Glu Leu Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu 
            580                 585                 590         


Gln Tyr Lys Glu Glu Ser Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln 
        595                 600                 605             


Asn Thr Gly Ser Lys Lys Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln 
    610                 615                 620                 


Phe Asn Arg Gly Gly Gly His Arg Gly Arg Gly Gly Phe Asn Met Arg 
625                 630                 635                 640 


Gly Gly Asn Phe Arg Gly Gly Ala Pro Gly Asn Arg Gly Gly Tyr Asn 
                645                 650                 655     


Arg Arg Gly Asn Met Pro Gln Arg Gly Gly Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Ile Gly Tyr Pro Tyr Pro Arg Ala Pro Val Phe Pro Gly Arg Gly 
        675                 680                 685             


Ser Tyr Ser Asn Arg Gly Asn Tyr Asn Arg Gly Gly Met Pro Asn Arg 
    690                 695                 700                 


Gly Asn Tyr Asn Gln Asn Phe Arg Gly Arg Gly Asn Asn Arg Gly Tyr 
705                 710                 715                 720 


Lys Asn Gln Ser Gln Gly Tyr Asn Gln Trp Gln Gln Gly Gln Phe Trp 
                725                 730                 735     


Gly Gln Lys Pro Trp Ser Gln His Tyr His Gln Gly Tyr Tyr 
            740                 745                 750 


<210> 7572
<211> 267
<212> PRT
<213> Homo sapiens

<400> 7572
Met Trp Asp Gln Arg Leu Val Lys Leu Ala Leu Leu Gln His Leu Arg 
1               5                   10                  15      


Ala Phe Tyr Gly Ile Lys Val Lys Gly Val Arg Gly Gln Cys Asp Arg 
            20                  25                  30          


Arg Arg His Glu Thr Ala Ala Thr Glu Ile Gly Gly Lys Ile Phe Gly 
        35                  40                  45              


Val Pro Phe Asn Ala Leu Pro His Ser Ala Val Pro Glu Tyr Gly His 
    50                  55                  60                  


Ile Pro Ser Phe Leu Val Asp Ala Cys Thr Ser Leu Glu Glu His Ile 
65                  70                  75                  80  


His Thr Glu Gly Leu Phe Arg Lys Ser Gly Ser Val Ile Arg Leu Lys 
                85                  90                  95      


Ala Leu Lys Asn Lys Val Asp His Gly Glu Gly Cys Leu Ser Ser Ala 
            100                 105                 110         


Pro Pro Cys Asp Ile Ala Gly Leu Leu Lys Gln Phe Phe Arg Glu Leu 
        115                 120                 125             


Pro Glu Pro Ile Leu Pro Ala Asp Leu His Glu Ala Leu Leu Lys Ala 
    130                 135                 140                 


Gln Gln Leu Gly Thr Glu Glu Lys Asn Lys Ala Ile Leu Leu Leu Ser 
145                 150                 155                 160 


Cys Leu Leu Ala Asp His Thr Val His Val Leu Arg Tyr Phe Phe Asn 
                165                 170                 175     


Phe Leu Arg Asn Val Ser Leu Arg Ser Ser Glu Asn Lys Met Asp Ser 
            180                 185                 190         


Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln Thr Ser Glu 
        195                 200                 205             


Gly His Glu Lys Met Ser Ser Asn Ala Glu Lys Lys Gly Val Tyr Gln 
    210                 215                 220                 


Thr Leu Ser Trp Lys Arg Tyr Gln Pro Cys Trp Val Leu Met Val Ser 
225                 230                 235                 240 


Val Leu Leu His His Trp Lys Ala Leu Lys Lys Val Asn Met Lys Leu 
                245                 250                 255     


Leu Val Asn Ile Arg Glu Arg Glu Asp Asn Val 
            260                 265         


<210> 7573
<211> 199
<212> PRT
<213> Homo sapiens

<400> 7573
Met Pro His Lys Ile Gly Phe Val Val Val Ser Ser Ser Gly His Glu 
1               5                   10                  15      


Asp Gly Phe Ser Ala Arg Glu Leu Met Ile His Ala Pro Thr Val Ser 
            20                  25                  30          


Gly Trp Arg Ser Pro Ser Tyr Val Ser Leu Cys Asp Asn Glu Lys Thr 
        35                  40                  45              


Gly Cys Lys Ala Arg Glu Leu Lys Ser Val Tyr Val Asp Ala Val Gly 
    50                  55                  60                  


Gln Phe Leu Lys Leu Ile Phe His Gln Asn His Val Asn Lys Tyr Asn 
65                  70                  75                  80  


Ile Tyr Asn Gln Val Ala Leu Val Ala Ile Asn Ile Ile Gly Asp Pro 
                85                  90                  95      


Ala Asp Phe Ser Asp Glu Ser Asn Thr Ala Ser Arg Glu Lys Leu Ile 
            100                 105                 110         


Asp His Tyr Leu Gly His Asn Ser Glu Asp Pro Ala Leu Glu Gly Thr 
        115                 120                 125             


Tyr Ala Arg Lys Ser Asp Tyr Ile Ser Pro Leu Asp Asp Leu Ala Phe 
    130                 135                 140                 


Asp Met Tyr Gln Asp Pro Glu Val Ala Gln Ile Ile Arg Lys Leu Asp 
145                 150                 155                 160 


Glu Arg Lys Arg Glu Ala Val Gln Lys Glu Arg Tyr Asp Tyr Ala Lys 
                165                 170                 175     


Lys Leu Lys Gln Ala Ile Ala Asp Leu Gln Lys Val Gly Glu Arg Leu 
            180                 185                 190         


Gly Arg Tyr Glu Val Glu Lys 
        195                 


<210> 7574
<211> 156
<212> PRT
<213> Homo sapiens

<400> 7574
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg 
145                 150                 155     


<210> 7575
<211> 909
<212> PRT
<213> Homo sapiens

<400> 7575
Met Ile Arg His Ala Gly Ala Pro Ala Arg Gly Asp Pro Thr Gly Pro 
1               5                   10                  15      


Val Pro Val Val Gly Lys Gly Glu Glu Glu Glu Glu Glu Asp Gly Met 
            20                  25                  30          


Arg Leu Cys Leu Pro Ala Asn Pro Lys Asn Cys Leu Pro His Arg Arg 
        35                  40                  45              


Gly Ile Ser Ile Leu Glu Lys Leu Ile Lys Thr Cys Pro Val Trp Leu 
    50                  55                  60                  


Gln Leu Ser Leu Gly Gln Ala Glu Val Ala Arg Ile Leu His Arg Val 
65                  70                  75                  80  


Val Ala Gly Met Phe Leu Val Arg Arg Asp Ser Ser Ser Lys Gln Leu 
                85                  90                  95      


Val Leu Cys Val His Phe Pro Ser Leu Asn Glu Ser Ser Ala Glu Val 
            100                 105                 110         


Leu Glu Tyr Thr Ile Lys Glu Glu Lys Ser Ile Leu Tyr Leu Glu Gly 
        115                 120                 125             


Ser Ala Leu Val Phe Glu Asp Ile Phe Arg Leu Ile Ala Phe Tyr Cys 
    130                 135                 140                 


Val Ser Arg Asp Leu Leu Pro Phe Thr Leu Arg Leu Pro Gln Ala Ile 
145                 150                 155                 160 


Leu Glu Ala Ser Ser Phe Thr Asp Leu Glu Thr Ile Ala Asn Leu Gly 
                165                 170                 175     


Leu Gly Phe Trp Asp Ser Ser Leu Asn Pro Pro Gln Glu Arg Gly Lys 
            180                 185                 190         


Pro Ala Glu Pro Pro Arg Asp Arg Ala Pro Gly Phe Pro Leu Val Ser 
        195                 200                 205             


Ser Leu Arg Pro Thr Ala His Asp Ala Asn Cys Ala Cys Glu Ile Glu 
    210                 215                 220                 


Leu Ser Val Gly Asn Asp Arg Leu Trp Phe Val Asn Pro Ile Phe Ile 
225                 230                 235                 240 


Glu Asp Cys Ser Ser Ala Leu Pro Thr Asp Gln Pro Pro Leu Gly Asn 
                245                 250                 255     


Cys Pro Ala Arg Pro Leu Pro Pro Thr Ser Asp Ala Thr Ser Pro Thr 
            260                 265                 270         


Ser Arg Trp Ala Pro Arg Arg Pro Pro Pro Pro Pro Pro Val Leu Pro 
        275                 280                 285             


Leu Gln Pro Cys Ser Pro Ala Gln Pro Pro Pro Leu Pro Ala Lys Lys 
    290                 295                 300                 


Asn Leu Pro Thr Ala Pro Pro Arg Arg Arg Val Ser Glu Arg Val Ser 
305                 310                 315                 320 


Leu Glu Asp Gln Ser Pro Gly Met Ala Ala Glu Gly Asp Gln Leu Ser 
                325                 330                 335     


Leu Pro Pro Gln Gly Thr Ser Asp Gly Pro Glu Asp Thr Pro Arg Glu 
            340                 345                 350         


Ser Thr Glu Gln Gly Gln Asp Thr Glu Val Lys Ala Ser Asp Pro His 
        355                 360                 365             


Ser Met Pro Glu Leu Pro Arg Thr Ala Lys Gln Pro Pro Val Pro Pro 
    370                 375                 380                 


Pro Arg Lys Lys Arg Ile Ser Arg Gln Leu Ala Ser Thr Leu Pro Ala 
385                 390                 395                 400 


Pro Leu Glu Asn Ala Glu Leu Cys Thr Gln Ala Met Ala Leu Glu Thr 
                405                 410                 415     


Pro Thr Pro Gly Pro Pro Arg Glu Gly Gln Ser Pro Ala Ser Gln Ala 
            420                 425                 430         


Gly Thr Gln His Pro Pro Ala Gln Ala Thr Ala His Ser Gln Ser Ser 
        435                 440                 445             


Pro Glu Phe Lys Gly Ser Leu Ala Ser Leu Ser Asp Ser Leu Gly Val 
    450                 455                 460                 


Ser Val Met Ala Thr Asp Gln Asp Ser Tyr Ser Thr Ser Ser Thr Glu 
465                 470                 475                 480 


Glu Glu Leu Glu Gln Phe Ser Ser Pro Ser Val Lys Lys Lys Pro Ser 
                485                 490                 495     


Met Ile Leu Gly Lys Ala Arg His Arg Leu Ser Phe Ala Ser Phe Ser 
            500                 505                 510         


Ser Met Phe His Ala Phe Leu Ser Asn Asn Arg Lys Leu Tyr Lys Lys 
        515                 520                 525             


Val Val Glu Leu Ala Gln Asp Lys Gly Ser Tyr Phe Gly Ser Leu Val 
    530                 535                 540                 


Gln Asp Tyr Lys Val Tyr Ser Leu Glu Met Met Ala Arg Gln Thr Ser 
545                 550                 555                 560 


Ser Thr Glu Met Leu Gln Glu Ile Arg Thr Met Met Thr Gln Leu Lys 
                565                 570                 575     


Ser Tyr Leu Leu Gln Ser Thr Glu Leu Lys Ala Leu Val Asp Pro Ala 
            580                 585                 590         


Leu His Ser Glu Glu Glu Leu Glu Ala Ile Val Glu Ser Ala Leu Tyr 
        595                 600                 605             


Lys Cys Val Leu Lys Pro Leu Lys Glu Ala Ile Asn Ser Cys Leu His 
    610                 615                 620                 


Gln Ile His Ser Lys Asp Gly Ser Leu Gln Gln Leu Lys Glu Asn Gln 
625                 630                 635                 640 


Leu Val Ile Leu Ala Thr Thr Thr Thr Asp Leu Gly Val Thr Thr Ser 
                645                 650                 655     


Val Pro Glu Val Pro Met Met Glu Lys Ile Leu Gln Lys Phe Thr Ser 
            660                 665                 670         


Met His Lys Ala Tyr Ser Pro Glu Lys Lys Ile Ser Ile Leu Leu Lys 
        675                 680                 685             


Thr Cys Lys Leu Ile Tyr Asp Ser Met Ala Leu Gly Asn Pro Gly Lys 
    690                 695                 700                 


Pro Tyr Gly Ala Asp Asp Phe Leu Pro Val Leu Met Tyr Val Leu Ala 
705                 710                 715                 720 


Arg Ser Asn Leu Thr Glu Met Leu Leu Asn Val Glu Tyr Met Met Glu 
                725                 730                 735     


Leu Met Asp Pro Ala Leu Gln Leu Gly Glu Gly Ser Tyr Tyr Leu Thr 
            740                 745                 750         


Thr Thr Tyr Gly Ala Leu Glu His Ile Lys Ser Tyr Asp Lys Ile Thr 
        755                 760                 765             


Val Thr Arg Gln Leu Ser Val Glu Val Gln Asp Ser Ile His Arg Trp 
    770                 775                 780                 


Glu Arg Arg Arg Thr Leu Asn Lys Ala Arg Ala Ser Arg Ser Ser Val 
785                 790                 795                 800 


Gln Asp Phe Ile Cys Val Ser Tyr Leu Glu Pro Glu Gln Gln Ala Arg 
                805                 810                 815     


Thr Leu Ala Ser Arg Ala Asp Thr Gln Ala Gln Ala Leu Cys Ala Gln 
            820                 825                 830         


Cys Ala Glu Lys Phe Ala Val Glu Arg Pro Gln Ala His Arg Leu Phe 
        835                 840                 845             


Val Leu Val Asp Gly Arg Cys Phe Gln Leu Ala Asp Asp Ala Leu Pro 
    850                 855                 860                 


His Cys Ile Lys Gly Tyr Leu Leu Arg Ser Glu Pro Lys Arg Asp Phe 
865                 870                 875                 880 


His Phe Val Tyr Arg Pro Leu Asp Gly Gly Gly Gly Gly Gly Gly Gly 
                885                 890                 895     


Ser Pro Pro Cys Leu Val Val Arg Glu Pro Asn Phe Leu 
            900                 905                 


<210> 7576
<211> 575
<212> PRT
<213> Homo sapiens

<400> 7576
Met Ser Ser Asp Glu Glu Lys Tyr Ser Leu Pro Val Val Gln Asn Asp 
1               5                   10                  15      


Ser Ser Arg Gly Ser Ser Val Ser Ser Asn Leu Gln Glu Glu Tyr Glu 
            20                  25                  30          


Glu Leu Leu His Tyr Ala Ile Val Thr Pro Asn Ile Glu Pro Cys Ala 
        35                  40                  45              


Ser Gln Ser Ser His Pro Lys Gly Glu Leu Val Pro Asp Val Arg Ile 
    50                  55                  60                  


Ser Thr Ile His Asp Ile Leu His Ser Gln Gly Asn Asn Ser Glu Val 
65                  70                  75                  80  


Arg Glu Thr Ala Ile Glu Val Gly Lys Gly Cys Asp Phe His Ile Ser 
                85                  90                  95      


Ser His Ser Lys Thr Asp Glu Ser Ser Pro Val Leu Ser Pro Arg Lys 
            100                 105                 110         


Pro Ser His Pro Val Met Asp Phe Phe Ser Ser His Leu Leu Ala Asp 
        115                 120                 125             


Ser Ser Ser Pro Ala Thr Asn Ser Ser His Thr Asp Ala His Glu Ile 
    130                 135                 140                 


Leu Val Ser Asp Phe Leu Val Ser Asp Glu Asn Leu Gln Lys Met Glu 
145                 150                 155                 160 


Asn Val Leu Asp Leu Trp Ser Ser Gly Leu Lys Thr Asn Ile Ile Ser 
                165                 170                 175     


Glu Leu Ser Lys Trp Arg Leu Asn Phe Ile Asp Trp His Arg Met Glu 
            180                 185                 190         


Met Arg Lys Glu Lys Glu Lys His Ala Ala His Leu Lys Gln Leu Cys 
        195                 200                 205             


Asn Gln Ile Asn Glu Leu Lys Glu Leu Gln Lys Thr Phe Glu Ile Ser 
    210                 215                 220                 


Ile Gly Arg Lys Asp Glu Val Ile Ser Ser Leu Ser His Ala Ile Gly 
225                 230                 235                 240 


Lys Gln Lys Glu Lys Ile Glu Leu Met Arg Thr Phe Phe His Trp Arg 
                245                 250                 255     


Ile Gly His Val Arg Ala Arg Gln Asp Val Tyr Glu Gly Lys Leu Ala 
            260                 265                 270         


Asp Gln Tyr Tyr Gln Arg Thr Leu Leu Lys Lys Val Trp Lys Val Trp 
        275                 280                 285             


Arg Ser Val Val Gln Lys Gln Trp Lys Asp Val Val Glu Arg Ala Cys 
    290                 295                 300                 


Gln Ala Arg Ala Glu Glu Val Cys Ile Gln Ile Ser Asn Asp Tyr Glu 
305                 310                 315                 320 


Ala Lys Val Ala Met Leu Ser Gly Ala Leu Glu Asn Ala Lys Ala Glu 
                325                 330                 335     


Ile Gln Arg Met Gln His Glu Lys Glu His Phe Glu Asp Ser Met Lys 
            340                 345                 350         


Lys Ala Phe Met Arg Gly Val Cys Ala Leu Asn Leu Glu Ala Met Thr 
        355                 360                 365             


Ile Phe Gln Asn Arg Asn Asp Ala Gly Ile Asp Ser Thr Asn Asn Lys 
    370                 375                 380                 


Lys Glu Glu Tyr Gly Pro Gly Val Gln Gly Lys Glu His Ser Ala His 
385                 390                 395                 400 


Leu Asp Pro Ser Ala Pro Pro Met Pro Leu Pro Val Thr Ser Pro Leu 
                405                 410                 415     


Leu Pro Ser Pro Pro Ala Ala Val Gly Gly Ala Ser Ala Thr Ala Val 
            420                 425                 430         


Pro Ser Ala Ala Ser Met Thr Ser Thr Arg Ala Ala Ser Ala Ser Ser 
        435                 440                 445             


Val His Val Pro Val Ser Ala Leu Gly Ala Gly Ser Ala Ala Thr Ala 
    450                 455                 460                 


Ala Ser Glu Glu Met Tyr Val Pro Arg Val Val Thr Ser Ala Gln Gln 
465                 470                 475                 480 


Lys Ala Gly Arg Thr Ile Thr Ala Arg Ile Thr Gly Arg Cys Asp Phe 
                485                 490                 495     


Ala Ser Lys Asn Arg Ile Ser Ser Ser Leu Ala Ile Met Gly Val Ser 
            500                 505                 510         


Pro Pro Met Ser Ser Val Val Val Glu Lys His His Pro Val Thr Val 
        515                 520                 525             


Gln Thr Ile Pro Gln Ala Thr Ala Ala Lys Tyr Pro Arg Thr Ile His 
    530                 535                 540                 


Pro Glu Ser Ser Thr Ser Ala Ser Arg Ser Leu Gly Thr Arg Ser Ala 
545                 550                 555                 560 


His Thr Gln Ser Leu Thr Ser Val His Ser Ile Lys Val Val Asp 
                565                 570                 575 


<210> 7577
<211> 696
<212> PRT
<213> Homo sapiens

<400> 7577
Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val Gly 
1               5                   10                  15      


Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp Ala 
            20                  25                  30          


Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr Glu 
        35                  40                  45              


Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp Val 
    50                  55                  60                  


Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile Gly 
65                  70                  75                  80  


Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys Ser 
                85                  90                  95      


Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly Gly 
            100                 105                 110         


Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr Ser 
        115                 120                 125             


Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro Thr 
    130                 135                 140                 


Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser Arg 
145                 150                 155                 160 


Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg Ala 
                165                 170                 175     


Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met Leu 
            180                 185                 190         


Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr 
        195                 200                 205             


Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu His 
    210                 215                 220                 


Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg Thr 
225                 230                 235                 240 


Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala Cys 
                245                 250                 255     


Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met Ser 
            260                 265                 270         


Ser Leu His Ile Ser Pro Asn Ser Gly Asn Val Thr Ser Ala Ser Gly 
        275                 280                 285             


Ser Gln Met Ala Ser Gly Ile Ser Leu Val Ser Phe Asn Ser Arg Pro 
    290                 295                 300                 


Asp Gly Met His Gln Arg Ser Tyr Ser Val Ser Ser Ala Asp Gln Trp 
305                 310                 315                 320 


Ser Glu Ala Thr Val Ile Ala Asn Ser Ala Ile Ser Ser Asp Thr Gly 
                325                 330                 335     


Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr Ser 
            340                 345                 350         


Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys His 
        355                 360                 365             


Arg Arg Lys Lys Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly 
    370                 375                 380                 


Thr Ala Glu Glu Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu 
385                 390                 395                 400 


Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp 
                405                 410                 415     


Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser 
            420                 425                 430         


Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu Ala 
        435                 440                 445             


Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys Val 
    450                 455                 460                 


Asp Cys Glu Thr Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala 
465                 470                 475                 480 


Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr His 
                485                 490                 495     


Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu Leu 
            500                 505                 510         


Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val Trp 
        515                 520                 525             


Glu Glu Ser Ser Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr Arg 
    530                 535                 540                 


Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe 
545                 550                 555                 560 


Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu 
                565                 570                 575     


Arg Ala Thr Ala Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu Ala 
            580                 585                 590         


His Gly Ser Arg Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly 
        595                 600                 605             


Arg Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala 
    610                 615                 620                 


Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala His 
625                 630                 635                 640 


Gly Asn Thr Ala Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys 
                645                 650                 655     


Ile Asp Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu 
            660                 665                 670         


Met Ala Thr Pro Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser 
        675                 680                 685             


Ser Gly Arg Val Pro Thr Ile Ile 
    690                 695     


<210> 7578
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7578
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 7579
<211> 594
<212> PRT
<213> Homo sapiens

<400> 7579
Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val 
            20                  25                  30          


Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr 
65                  70                  75                  80  


Asp Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Val Asn Phe Leu 
                85                  90                  95      


Lys Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg Asp 
            100                 105                 110         


Ala Phe Phe Lys Thr Leu Ser Asn Met Gly Ile Leu Pro Ala Leu Glu 
        115                 120                 125             


Val Ile Leu Gly Met Asp Asp Thr Gln Val Arg Ser Ala Ala Thr Asp 
    130                 135                 140                 


Ile Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met Val Arg Glu Phe 
145                 150                 155                 160 


Val Met Gln Glu Ala Gln Gln Asn Asp Asp Val Ser Lys Lys Leu Thr 
                165                 170                 175     


Glu Gln Lys Ile Thr Ser Lys Asp Ile Leu Leu Ile Asn Leu Ile Ile 
            180                 185                 190         


Glu His Met Ile Cys Asp Thr Asp Pro Glu Leu Gly Gly Ala Val Gln 
        195                 200                 205             


Leu Met Gly Leu Leu Arg Thr Leu Val Asp Pro Glu Asn Met Leu Ala 
    210                 215                 220                 


Thr Ala Asn Lys Thr Glu Lys Thr Glu Phe Leu Gly Phe Phe Tyr Lys 
225                 230                 235                 240 


His Cys Met His Val Leu Thr Ala Pro Leu Leu Ala Asn Thr Thr Glu 
                245                 250                 255     


Asp Lys Pro Ser Lys Asp Asp Phe Gln Thr Ala Gln Leu Leu Ala Leu 
            260                 265                 270         


Val Leu Glu Leu Leu Thr Phe Cys Val Glu His His Thr Tyr His Ile 
        275                 280                 285             


Lys Asn Tyr Ile Ile Asn Lys Asp Ile Leu Arg Arg Val Leu Val Leu 
    290                 295                 300                 


Met Ala Ser Lys His Ala Phe Leu Ala Leu Cys Ala Leu Arg Phe Lys 
305                 310                 315                 320 


Arg Lys Ile Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr Ile Met 
                325                 330                 335     


Lys Ser Phe Leu Phe Glu Pro Val Val Lys Ala Phe Leu Asn Asn Gly 
            340                 345                 350         


Ser Arg Tyr Asn Leu Met Asn Ser Ala Ile Ile Glu Met Phe Glu Phe 
        355                 360                 365             


Ile Arg Val Glu Asp Ile Lys Ser Leu Thr Ala His Val Ile Glu Asn 
    370                 375                 380                 


Tyr Trp Lys Ala Leu Glu Asp Val Asp Tyr Val Gln Thr Phe Lys Gly 
385                 390                 395                 400 


Leu Lys Leu Arg Phe Glu Gln Gln Arg Glu Arg Gln Asp Asn Pro Lys 
                405                 410                 415     


Leu Asp Ser Met Arg Ser Ile Leu Arg Asn His Arg Tyr Arg Arg Asp 
            420                 425                 430         


Ala Arg Thr Leu Glu Asp Glu Glu Glu Met Trp Phe Asn Thr Asp Glu 
        435                 440                 445             


Asp Asp Met Glu Asp Gly Glu Ala Val Val Ser Pro Ser Asp Lys Thr 
    450                 455                 460                 


Lys Asn Asp Asp Asp Ile Met Asp Pro Ile Ser Lys Phe Met Glu Arg 
465                 470                 475                 480 


Lys Lys Leu Lys Glu Ser Glu Glu Lys Glu Val Leu Leu Lys Thr Asn 
                485                 490                 495     


Leu Ser Gly Arg Gln Ser Pro Ser Phe Lys Leu Ser Leu Ser Ser Gly 
            500                 505                 510         


Thr Lys Thr Asn Leu Thr Ser Gln Ser Ser Thr Thr Asn Leu Pro Gly 
        515                 520                 525             


Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser 
    530                 535                 540                 


Val Pro Lys Asn Thr Ser Gln Thr Ala Ala Ile Thr Thr Lys Gly Gly 
545                 550                 555                 560 


Leu Val Gly Leu Val Asp Tyr Pro Asp Asp Asp Glu Asp Asp Asp Glu 
                565                 570                 575     


Asp Glu Asp Lys Glu Asp Thr Leu Pro Leu Ser Lys Lys Ala Lys Phe 
            580                 585                 590         


Asp Ser 
        


<210> 7580
<211> 173
<212> PRT
<213> Homo sapiens

<400> 7580
Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
1               5                   10                  15      


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
            20                  25                  30          


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
        35                  40                  45              


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
    50                  55                  60                  


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
65                  70                  75                  80  


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
                85                  90                  95      


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
            100                 105                 110         


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
        115                 120                 125             


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
    130                 135                 140                 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
145                 150                 155                 160 


Phe His Arg Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
                165                 170             


<210> 7581
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7581
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7582
<211> 703
<212> PRT
<213> Homo sapiens

<400> 7582
Met Phe Arg Tyr Glu Ser Leu Glu Asp Cys Pro Leu Asp Glu Asp Glu 
1               5                   10                  15      


Asp Ala Phe Gln Gly Leu Gly Glu Glu Asp Glu Glu Ile Asp Gln Phe 
            20                  25                  30          


Asn Asp Asp Thr Phe Gly Ser Gly Ala Val Asp Asp Asp Trp Gln Glu 
        35                  40                  45              


Ala His Glu Arg Leu Ala Glu Leu Glu Glu Lys Leu Pro Val Ala Val 
    50                  55                  60                  


Asn Glu Gln Thr Gly Asn Gly Glu Arg Asp Glu Met Asp Leu Leu Gly 
65                  70                  75                  80  


Asp His Glu Glu Asn Leu Ala Glu Arg Leu Ser Lys Met Val Ile Glu 
                85                  90                  95      


Asn Glu Leu Glu Asp Pro Ala Ile Met Arg Ala Val Gln Thr Arg Pro 
            100                 105                 110         


Val Leu Gln Pro Gln Pro Gly Ser Leu Asn Ser Ser Ile Trp Asp Gly 
        115                 120                 125             


Ser Glu Val Leu Arg Arg Ile Arg Gly Pro Leu Leu Ala Gln Glu Met 
    130                 135                 140                 


Pro Thr Val Ser Val Leu Glu Tyr Ala Leu Pro Gln Arg Pro Pro Gln 
145                 150                 155                 160 


Gly Pro Glu Asp Asp Arg Asp Leu Ser Glu Arg Ala Leu Pro Arg Arg 
                165                 170                 175     


Ser Thr Ser Pro Ile Ile Gly Ser Pro Pro Val Arg Ala Val Pro Ile 
            180                 185                 190         


Gly Thr Pro Pro Lys Gln Met Ala Val Pro Ser Phe Thr Gln Gln Ile 
        195                 200                 205             


Leu Cys Pro Lys Pro Val His Val Arg Pro Pro Met Pro Pro Arg Tyr 
    210                 215                 220                 


Pro Ala Pro Tyr Gly Glu Arg Met Ser Pro Asn Gln Leu Cys Ser Val 
225                 230                 235                 240 


Pro Leu Gln Pro Gly Arg Met Ser Pro Ser Gln Phe Ala Arg Val Pro 
                245                 250                 255     


Gly Phe Val Gly Ser Pro Leu Ala Ala Met Asn Pro Lys Leu Leu Gln 
            260                 265                 270         


Gly Arg Val Gly Gln Met Leu Pro Pro Ala Pro Gly Phe Arg Ala Phe 
        275                 280                 285             


Phe Ser Ala Pro Pro Ser Ala Thr Pro Pro Pro Gln Gln His Pro Pro 
    290                 295                 300                 


Gly Pro Gly Pro His Leu Gln Asn Leu Arg Ser Gln Ala Pro Met Phe 
305                 310                 315                 320 


Arg Pro Asp Thr Thr His Leu His Pro Gln His Arg Arg Leu Leu His 
                325                 330                 335     


Gln Arg Gln Gln Gln Asn Arg Ser Gln His Arg Asn Leu Asn Gly Ala 
            340                 345                 350         


Gly Asp Arg Gly Ser His Arg Ser Ser His Gln Asp His Leu Arg Lys 
        355                 360                 365             


Asp Pro Tyr Ala Asn Leu Met Leu Gln Arg Glu Lys Asp Trp Val Ser 
    370                 375                 380                 


Lys Ile Gln Met Met Gln Leu Gln Ser Thr Asp Pro Tyr Leu Asp Asp 
385                 390                 395                 400 


Phe Tyr Tyr Gln Asn Tyr Phe Glu Lys Leu Glu Lys Leu Ser Ala Ala 
                405                 410                 415     


Glu Glu Ile Gln Gly Asp Gly Pro Lys Lys Glu Arg Thr Lys Leu Ile 
            420                 425                 430         


Thr Pro Gln Val Ala Lys Leu Glu His Ala Tyr Lys Pro Val Gln Phe 
        435                 440                 445             


Glu Gly Ser Leu Gly Lys Leu Thr Val Ser Ser Val Asn Asn Pro Arg 
    450                 455                 460                 


Lys Met Ile Asp Ala Val Val Thr Ser Arg Ser Glu Asp Asp Glu Thr 
465                 470                 475                 480 


Lys Glu Lys Gln Val Arg Asp Lys Arg Arg Lys Thr Leu Val Ile Ile 
                485                 490                 495     


Glu Lys Thr Tyr Ser Leu Leu Leu Asp Val Glu Asp Tyr Glu Arg Arg 
            500                 505                 510         


Tyr Leu Leu Ser Leu Glu Glu Glu Arg Pro Ala Leu Met Asp Asp Arg 
        515                 520                 525             


Lys His Lys Ile Cys Ser Met Tyr Asp Asn Leu Arg Gly Lys Leu Pro 
    530                 535                 540                 


Gly Gln Glu Arg Pro Ser Asp Asp His Phe Val Gln Ile Met Cys Ile 
545                 550                 555                 560 


Arg Lys Gly Lys Arg Met Val Ala Arg Ile Leu Pro Phe Leu Ser Thr 
                565                 570                 575     


Glu Gln Ala Ala Asp Ile Leu Met Thr Thr Ala Arg Asn Leu Pro Phe 
            580                 585                 590         


Leu Ile Lys Lys Asp Ala Gln Asp Glu Val Leu Pro Cys Leu Leu Ser 
        595                 600                 605             


Pro Phe Ser Leu Leu Leu Tyr His Leu Pro Ser Val Ser Ile Thr Ser 
    610                 615                 620                 


Leu Leu Arg Gln Leu Met Asn Leu Pro Ser Ser Asp Pro Ala Thr Glu 
625                 630                 635                 640 


Ser Thr Gln Asn Asn Gln Trp Thr Glu Val Met Phe Met Ala Thr Arg 
                645                 650                 655     


Glu Leu Leu Arg Ile Pro Gln Ala Ala Leu Ala Lys Pro Ile Ser Ile 
            660                 665                 670         


Pro Thr Asn Leu Val Ser Leu Phe Ser Arg Tyr Val Asp Arg Gln Lys 
        675                 680                 685             


Leu Asn Leu Leu Glu Thr Lys Leu Gln Leu Val Gln Gly Ile Arg 
    690                 695                 700             


<210> 7583
<211> 318
<212> PRT
<213> Homo sapiens

<400> 7583
Met Ser Ala His Asn Arg Gly Thr Glu Leu Asp Leu Ser Trp Ile Ser 
1               5                   10                  15      


Lys Ile Gln Val Asn His Pro Ala Val Leu Arg Arg Ala Glu Gln Ile 
            20                  25                  30          


Gln Ala Arg Arg Thr Val Lys Lys Glu Trp Gln Ala Ala Trp Leu Leu 
        35                  40                  45              


Lys Ala Val Thr Phe Ile Asp Leu Thr Thr Leu Ser Gly Asp Asp Thr 
    50                  55                  60                  


Ser Ser Asn Ile Gln Arg Leu Cys Tyr Lys Ala Lys Tyr Pro Ile Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Lys Ala Leu Asn Met His Asp Lys Gly Ile Thr Thr 
                85                  90                  95      


Ala Ala Val Cys Val Tyr Pro Ala Arg Val Cys Asp Ala Val Lys Ala 
            100                 105                 110         


Leu Lys Ala Ala Gly Cys Asn Ile Pro Val Ala Ser Val Ala Ala Gly 
        115                 120                 125             


Phe Pro Ala Gly Gln Thr His Leu Lys Thr Arg Leu Glu Glu Ile Arg 
    130                 135                 140                 


Leu Ala Val Glu Asp Gly Ala Thr Glu Ile Asp Val Val Ile Asn Arg 
145                 150                 155                 160 


Ser Leu Val Leu Thr Gly Gln Trp Glu Ala Leu Tyr Asp Glu Ile Arg 
                165                 170                 175     


Gln Phe Arg Lys Ala Cys Gly Glu Ala His Leu Lys Thr Ile Leu Ala 
            180                 185                 190         


Thr Gly Glu Leu Gly Thr Leu Thr Asn Val Tyr Lys Ala Ser Met Ile 
        195                 200                 205             


Ala Met Met Ala Gly Ser Asp Phe Ile Lys Thr Ser Thr Gly Lys Glu 
    210                 215                 220                 


Thr Val Asn Ala Thr Phe Pro Val Ala Ile Val Met Leu Arg Ala Ile 
225                 230                 235                 240 


Arg Asp Phe Phe Trp Lys Thr Gly Asn Lys Ile Gly Phe Lys Pro Ala 
                245                 250                 255     


Gly Gly Ile Arg Ser Ala Lys Asp Ser Leu Ala Trp Leu Ser Leu Val 
            260                 265                 270         


Lys Glu Glu Leu Gly Asp Glu Trp Leu Lys Pro Glu Leu Phe Arg Ile 
        275                 280                 285             


Gly Ala Ser Thr Leu Leu Ser Asp Ile Glu Arg Gln Ile Tyr His His 
    290                 295                 300                 


Val Thr Gly Arg Tyr Ala Ala Tyr His Asp Leu Pro Met Ser 
305                 310                 315             


<210> 7584
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7584
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210> 7585
<211> 1095
<212> PRT
<213> Homo sapiens

<400> 7585
Met Ala Glu Gly Ala Ala Gly Arg Glu Asp Pro Ala Pro Pro Asp Ala 
1               5                   10                  15      


Ala Gly Gly Glu Asp Asp Pro Arg Val Gly Pro Asp Ala Ala Gly Asp 
            20                  25                  30          


Cys Val Thr Ala Ala Ser Gly Gly Arg Met Arg Asp Arg Arg Ser Gly 
        35                  40                  45              


Val Ala Leu Pro Gly Ala Ala Gly Thr Pro Ala Asp Ser Glu Ala Gly 
    50                  55                  60                  


Leu Leu Glu Ala Ala Arg Ala Thr Pro Arg Arg Ser Ser Ile Ile Lys 
65                  70                  75                  80  


Asp Pro Ser Asn Gln Lys Cys Gly Gly Arg Lys Lys Thr Val Ser Phe 
                85                  90                  95      


Ser Ser Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile 
            100                 105                 110         


Ser Phe Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser 
        115                 120                 125             


Arg Ile Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu 
    130                 135                 140                 


Arg Trp Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile 
145                 150                 155                 160 


Ser Ala Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Arg 
                165                 170                 175     


Asn Asn Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile 
            180                 185                 190         


Leu His Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala 
        195                 200                 205             


Asp Val Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg 
    210                 215                 220                 


Ser Lys Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg 
225                 230                 235                 240 


Phe Met Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn 
                245                 250                 255     


Gly Ile Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn 
            260                 265                 270         


Pro Thr Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln 
        275                 280                 285             


Lys Ser Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys 
    290                 295                 300                 


Glu Ala Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu 
305                 310                 315                 320 


Val Gln Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met 
                325                 330                 335     


Leu Phe Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile 
            340                 345                 350         


Cys Leu Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln 
        355                 360                 365             


Lys Gly Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser 
    370                 375                 380                 


Glu Cys Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met 
385                 390                 395                 400 


Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr 
                405                 410                 415     


Leu Ile Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile 
            420                 425                 430         


Arg Ala Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp 
        435                 440                 445             


Gly Ser Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr 
    450                 455                 460                 


His Val Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe 
465                 470                 475                 480 


Val Ala Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser 
                485                 490                 495     


Leu Pro Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly 
            500                 505                 510         


Asn Lys Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro 
        515                 520                 525             


Ser Pro Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu 
    530                 535                 540                 


Pro Ser Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu 
545                 550                 555                 560 


Glu Ala Glu Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln 
                565                 570                 575     


Lys Gln Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys 
            580                 585                 590         


Lys Ser Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn 
        595                 600                 605             


Tyr Trp Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala 
    610                 615                 620                 


Asn Glu Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser 
625                 630                 635                 640 


Arg Ile Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro 
                645                 650                 655     


Gln Asp Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln 
            660                 665                 670         


Thr Pro Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn 
        675                 680                 685             


Gly Gly Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val 
    690                 695                 700                 


Ser Tyr Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro 
705                 710                 715                 720 


Leu Ala Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro 
                725                 730                 735     


Lys Gly Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile 
            740                 745                 750         


Glu Ile His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr 
        755                 760                 765             


Val Gln Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe 
    770                 775                 780                 


Gln Val Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp 
785                 790                 795                 800 


Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe 
                805                 810                 815     


Glu Cys Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val 
            820                 825                 830         


Gly Asp Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr 
        835                 840                 845             


Asn Arg Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg 
    850                 855                 860                 


Met Gly Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu 
865                 870                 875                 880 


Lys Thr Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu 
                885                 890                 895     


Ala Ile Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys 
            900                 905                 910         


Glu Leu Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu 
        915                 920                 925             


Thr Leu Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser 
    930                 935                 940                 


Leu Val Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile 
945                 950                 955                 960 


Pro Asp Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln 
                965                 970                 975     


Glu Ser Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile 
            980                 985                 990         


Val Gln Cys Gln Lys Ala Gly Met  Glu Phe His Glu Glu  Leu His Asn 
        995                 1000                 1005             


Leu Gly  Ala Lys Glu Gly Leu  Lys Gly Arg Lys Leu  Asn Lys Ala 
    1010                 1015                 1020             


Thr Glu  Ser Phe Ala Trp Asn  Ile Thr Val Leu Lys  Gly Gln Gly 
    1025                 1030                 1035             


Asp Leu  Leu Lys Asn Ala Lys  Asn Glu Ala Ile Glu  Asn Met Lys 
    1040                 1045                 1050             


Gln Ile  Gln Leu Ala Cys Leu  Ser Cys Gly Leu Ser  Lys Ala Pro 
    1055                 1060                 1065             


Ser Ser  Ser Ala Glu Ala Lys  Ser Lys Arg Ser Leu  Glu Ala Ile 
    1070                 1075                 1080             


Glu Glu  Lys Glu Ser Ser Glu  Glu Asn Gly Lys Leu  
    1085                 1090                 1095 


<210> 7586
<211> 180
<212> PRT
<213> Homo sapiens

<400> 7586
Met Glu Gln Pro Lys Gly Val Asp Trp Thr Val Ile Ile Leu Thr Cys 
1               5                   10                  15      


Gln Tyr Lys Asp Ser Val Gln Val Phe Gln Arg Glu Leu Glu Val Arg 
            20                  25                  30          


Gln Lys Arg Glu Gln Ile Pro Ala Gly Thr Leu Leu Leu Ala Val Glu 
        35                  40                  45              


Asp Pro Glu Lys Arg Val Gly Ser Gly Gly Ala Thr Leu Asn Ala Leu 
    50                  55                  60                  


Leu Val Ala Ala Glu His Leu Ser Ala Arg Ala Gly Phe Thr Gly Arg 
65                  70                  75                  80  


Asp Phe Pro Phe Asp Asp Cys Gly Arg Ala Phe Thr Cys Leu Pro Val 
                85                  90                  95      


Glu Asn Pro Glu Ala Pro Val Glu Ala Leu Val Cys Asn Leu Asp Cys 
            100                 105                 110         


Leu Leu Asp Ile Met Thr Tyr Arg Leu Gly Pro Gly Ser Pro Pro Gly 
        115                 120                 125             


Val Trp Val Cys Ser Thr Asp Met Leu Leu Ser Val Pro Ala Asn Pro 
    130                 135                 140                 


Gly Glu Pro Glu Thr Thr Trp Asp Cys Leu Pro Ser Ser Gln Pro Gln 
145                 150                 155                 160 


Gln Glu Ala Ser Ser Ala Leu Leu Ala His Pro Ala Ser Gly Pro Ala 
                165                 170                 175     


Pro Leu Pro Tyr 
            180 


<210> 7587
<211> 142
<212> PRT
<213> Homo sapiens

<400> 7587
Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210> 7588
<211> 113
<212> PRT
<213> Homo sapiens

<400> 7588
Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln 
1               5                   10                  15      


Pro Arg Trp Phe Leu Leu Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser 
            20                  25                  30          


Pro Glu Asp Ala Trp Lys Gly Cys Lys Gly Ser Ile Gln Met Ala Val 
        35                  40                  45              


Cys Glu Ile Gln Val His Ser Val Asp Asn Thr Arg Met Asp Leu Ile 
    50                  55                  60                  


Ile Pro Gly Glu Gln Tyr Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu 
65                  70                  75                  80  


Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr 
                85                  90                  95      


Asp Ser Arg Thr Gln Lys Glu Lys Gly Asn Leu Leu Lys Thr Leu Lys 
            100                 105                 110         


Thr 
    


<210> 7589
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7589
Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser Val 
        115                 120                 125             


Tyr Leu Ser Tyr Glu Lys Arg Ala Glu Thr Leu Ala Val Glu Ile Lys 
    130                 135                 140                 


Glu Leu Gln Gly Gln Leu Ala Asp Tyr Asn Met Leu Val Asp Lys Leu 
145                 150                 155                 160 


Asn Thr Asn Thr Glu Met Glu Glu Val Met Asn Asp Tyr Asn Met Leu 
                165                 170                 175     


Lys Ala Gln Asn Asp Arg Glu Thr Gln Ser Leu Asp Val Ile Phe Thr 
            180                 185                 190         


Glu Arg Gln Ala Lys Glu Lys Gln Ile Arg Ser Val Glu Glu Glu Ile 
        195                 200                 205             


Glu Gln Glu Lys Gln Ala Thr Asp Asp Ile Ile Lys Asn Met Ser Phe 
    210                 215                 220                 


Glu Asn Gln Val Lys Tyr Leu Glu Met Lys Thr Thr Asn Glu Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Asp Thr Leu Gln Gln Gln Leu Asp Ser Gln Asn Met 
                245                 250                 255     


Lys Lys Glu Ser Leu Glu Ala Glu Ile Ala His Ser Gln Val Lys Gln 
            260                 265                 270         


Glu Ala Val Leu Leu His Glu Lys Leu Tyr Glu Leu Glu Ser His Arg 
        275                 280                 285             


Asp Gln Met Ile Ala Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala 
305                 310                 315                 320 


Ser Met Glu Arg Gln Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe 
                325                 330                 335     


Ile Glu Glu Ile Arg Gln Leu Asp Met Asp Leu Glu Glu His Gln Asp 
            340                 345                 350         


Pro Thr Asn Tyr Gly Trp Lys Ile Leu Glu Lys Asn Thr Gly Ser Phe 
        355                 360                 365             


Lys Lys Gln Val 
    370         


<210> 7590
<211> 114
<212> PRT
<213> Homo sapiens

<400> 7590
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys 
        


<210> 7591
<211> 108
<212> PRT
<213> Homo sapiens

<400> 7591
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg 
            100                 105             


<210> 7592
<211> 182
<212> PRT
<213> Homo sapiens

<400> 7592
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Trp Cys Pro Thr 
65                  70                  75                  80  


Gly Phe Lys Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly 
                85                  90                  95      


Gly Asp Leu Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr 
            100                 105                 110         


Thr Ala Ile Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu 
        115                 120                 125             


Met Tyr Ala Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met 
    130                 135                 140                 


Glu Glu Gly Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu 
145                 150                 155                 160 


Lys Asp Tyr Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu 
                165                 170                 175     


Glu Glu Gly Glu Glu Tyr 
            180         


<210> 7593
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7593
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7594
<211> 1160
<212> PRT
<213> Homo sapiens

<400> 7594
Met Ala Cys Arg Arg Arg Tyr Phe Val Glu Gly Glu Ala Pro Ser Ser 
1               5                   10                  15      


Glu Thr Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro 
            20                  25                  30          


Leu Val Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser 
        35                  40                  45              


Val Gly Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg 
    50                  55                  60                  


Thr Arg Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln 
65                  70                  75                  80  


Ala Glu Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr 
                85                  90                  95      


Glu Leu Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg 
            100                 105                 110         


Lys Tyr Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln 
        115                 120                 125             


Thr Ala Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg 
    130                 135                 140                 


Ser Ser Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn 
145                 150                 155                 160 


Met Arg Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser 
                165                 170                 175     


Tyr Phe Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu 
            180                 185                 190         


Gly Ala Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr 
        195                 200                 205             


Leu Lys Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu 
    210                 215                 220                 


Leu Glu Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile 
225                 230                 235                 240 


Asp Asp Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala 
                245                 250                 255     


Leu Asp Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His 
            260                 265                 270         


Gly Met Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp 
        275                 280                 285             


Val Thr Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu 
    290                 295                 300                 


Ser Gln Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu 
305                 310                 315                 320 


Arg Ala Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu 
                325                 330                 335     


Asp Lys Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu 
            340                 345                 350         


Arg Gln Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile 
        355                 360                 365             


Glu Pro Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg 
    370                 375                 380                 


Gly Ser Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln 
385                 390                 395                 400 


Gln Gly Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu 
                405                 410                 415     


Pro Arg Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp 
            420                 425                 430         


Ser His Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu 
        435                 440                 445             


Ser Asp Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn 
    450                 455                 460                 


Ser Asn Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser 
465                 470                 475                 480 


Leu Arg Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg 
                485                 490                 495     


Asn Ser Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg 
            500                 505                 510         


His Tyr Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly 
        515                 520                 525             


Val Gln Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly 
    530                 535                 540                 


Val Ala His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile 
545                 550                 555                 560 


Gly Glu Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu 
                565                 570                 575     


Asp Cys Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu 
            580                 585                 590         


Ala Leu Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln 
        595                 600                 605             


Lys Val Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys 
    610                 615                 620                 


Asn Pro Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile 
625                 630                 635                 640 


Leu Ala Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn 
                645                 650                 655     


Val Lys Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu 
            660                 665                 670         


Arg Gly Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly 
        675                 680                 685             


Ile Tyr Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His 
    690                 695                 700                 


Val Ser Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro 
705                 710                 715                 720 


Ile Gly Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His 
                725                 730                 735     


Arg Arg Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn 
            740                 745                 750         


Lys Pro Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn 
        755                 760                 765             


Asp Leu Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val 
    770                 775                 780                 


Thr Tyr Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu 
785                 790                 795                 800 


Leu Phe Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser 
                805                 810                 815     


Val Pro Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn 
            820                 825                 830         


Pro Gln Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala 
        835                 840                 845             


Glu Val Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys 
    850                 855                 860                 


Gln Lys Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys 
865                 870                 875                 880 


Lys Glu Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser 
                885                 890                 895     


Tyr Ala Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu 
            900                 905                 910         


Arg Asp Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg Ser Ser Ala Gly 
        915                 920                 925             


Ser Leu Glu Ser Asn Val Glu Gly Ser Ile Ile Ser Ser Pro His Met 
    930                 935                 940                 


Arg Arg Arg Ala Thr Ser Thr Arg Glu Cys Pro Ser Arg Pro His Gln 
945                 950                 955                 960 


Thr Met Pro Asn Ser Ser Ser Leu Leu Gly Ser Leu Phe Gly Ser Lys 
                965                 970                 975     


Arg Gly Lys Pro Pro Pro Gln Ala His Leu Pro Ser Ala Pro Ala Leu 
            980                 985                 990         


Ala Thr Pro Pro Pro Thr Gly Gly  Pro Ala Ser Leu Ala  Ala Leu Cys 
        995                 1000                 1005             


Gly Trp  Pro Pro Pro Gly Ala  Pro Arg Gly Ala Ala  Ala Gly Arg 
    1010                 1015                 1020             


His Ala  Arg Ala Ser His Pro  Val Leu Pro His Ala  Glu Pro Ser 
    1025                 1030                 1035             


Pro Val  Pro Pro Ser Pro Pro  Pro Pro Pro Thr Pro  Ala His Pro 
    1040                 1045                 1050             


Ala Arg  Thr Pro Val Pro Pro  Arg Pro Pro Trp Gly  Pro Pro Ser 
    1055                 1060                 1065             


Leu Arg  Gly Pro Cys Pro Arg  Pro Pro Ala Ala Ala  Leu Gly Pro 
    1070                 1075                 1080             


Arg Gly  Ala His Ser Ala Pro  Pro Trp Ala Ala Pro  Cys Pro Ala 
    1085                 1090                 1095             


Ala Pro  His Gln Gln Gln Gly  Gln Thr Gln Arg His  Gln His Asn 
    1100                 1105                 1110             


Cys Val  Asp Ser Leu Gly Arg  Gly Pro Arg Leu Pro  Glu Thr Pro 
    1115                 1120                 1125             


Ala His  His Thr Gly His Ala  Arg Gly Ser Pro Ala  Ala His Gln 
    1130                 1135                 1140             


Thr Arg  Gly Thr Ser Val Ala  Ile Ser Pro Leu Cys  Pro Ser Arg 
    1145                 1150                 1155             


Pro Asn  
    1160 


<210> 7595
<211> 125
<212> PRT
<213> Homo sapiens

<400> 7595
Met Lys Lys Glu His Val Leu His Cys Gln Phe Ser Ala Trp Tyr Pro 
1               5                   10                  15      


Phe Phe Arg Gly Val Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
            20                  25                  30          


Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
        35                  40                  45              


Arg Asp Asp Pro Pro Thr His Ser Gln Pro Asp Ser Asp Asp Glu Ala 
    50                  55                  60                  


Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn Thr Ala Thr Leu Thr Asp 
65                  70                  75                  80  


Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Thr Leu Ser 
                85                  90                  95      


Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr Arg Asp Phe 
            100                 105                 110         


Thr Gln Pro Phe Ile His Cys Thr Asp Asp Ser Pro Asp 
        115                 120                 125 


<210> 7596
<211> 137
<212> PRT
<213> Homo sapiens

<400> 7596
Met Ser Leu Phe Gly Thr Thr Ser Gly Phe Gly Thr Ser Gly Thr Ser 
1               5                   10                  15      


Met Phe Gly Ser Ala Thr Thr Asp Asn His Asn Pro Met Lys Asp Ile 
            20                  25                  30          


Glu Val Thr Ser Ser Pro Asp Asp Ser Ile Gly Cys Leu Ser Phe Ser 
        35                  40                  45              


Pro Pro Thr Leu Pro Gly Asn Phe Leu Ile Ala Gly Ser Trp Ala Asn 
    50                  55                  60                  


Asp Val Arg Cys Trp Glu Val Gln Asp Ser Gly Gln Thr Ile Pro Lys 
65                  70                  75                  80  


Ala Gln Gln Met His Thr Gly Pro Val Leu Asp Val Cys Trp Ser Asp 
                85                  90                  95      


Asp Gly Ser Lys Val Phe Thr Ala Ser Cys Asp Lys Thr Ala Lys Met 
            100                 105                 110         


Trp Asp Leu Ser Ser Asn Gln Ala Ile Gln Ile Ala Gln His Asp Ala 
        115                 120                 125             


Pro Val Lys Thr Ile His Trp Ile Lys 
    130                 135         


<210> 7597
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 7597
Met Glu Glu Arg Lys His Glu Thr Met Asn Pro Ala His Val Leu Phe 
1               5                   10                  15      


Asp Arg Phe Val Gln Ala Thr Thr Cys Lys Gly Thr Leu Lys Ala Phe 
            20                  25                  30          


Gln Glu Leu Cys Asp His Leu Glu Leu Lys Pro Lys Asp Tyr Arg Ser 
        35                  40                  45              


Phe Tyr His Lys Leu Lys Ser Lys Leu Asn Tyr Trp Lys Ala Lys Ala 
    50                  55                  60                  


Leu Trp Ala Lys Leu Asp Lys Arg Gly Ser His Lys Asp Tyr Lys Lys 
65                  70                  75                  80  


Gly Lys Ala Cys Thr Asn Thr Lys Cys Leu Ile Ile Gly Ala Gly Pro 
                85                  90                  95      


Cys Gly Leu Arg Thr Ala Ile Asp Leu Ser Leu Leu Gly Ala Lys Val 
            100                 105                 110         


Val Val Ile Glu Lys Arg Asp Ala Phe Ser Arg Asn Asn Val Leu His 
        115                 120                 125             


Leu Trp Pro Phe Thr Ile His Asp Leu Arg Gly Leu Gly Ala Lys Lys 
    130                 135                 140                 


Phe Tyr Gly Lys Phe Cys Ala Gly Ala Ile Asp His Ile Ser Ile Arg 
145                 150                 155                 160 


Gln Leu Gln Leu Ile Leu Leu Lys Val Ala Leu Ile Leu Gly Ile Glu 
                165                 170                 175     


Ile His Val Asn Val Glu Phe Gln Gly Leu Ile Gln Pro Pro Glu Asp 
            180                 185                 190         


Gln Glu Asn Glu Arg Ile Gly Trp Arg Ala Leu Val His Pro Lys Thr 
        195                 200                 205             


His Pro Val Ser Glu Tyr Glu Phe Glu Val Ile Ile Gly Gly Asp Gly 
    210                 215                 220                 


Arg Arg Asn Thr Leu Glu Gly Phe Arg Arg Lys Glu Phe Arg Gly Lys 
225                 230                 235                 240 


Leu Ala Ile Ala Ile Thr Ala Asn Phe Ile Asn Arg Asn Thr Thr Ala 
                245                 250                 255     


Glu Ala Lys Val Glu Glu Ile Ser Gly Val Ala Phe Ile Phe Asn Gln 
            260                 265                 270         


Lys Phe Phe Gln Glu Leu Arg Glu Ala Thr Gly Ile Asp Leu Glu Asn 
        275                 280                 285             


Ile Val Tyr Tyr Lys Asp Asp Thr His Tyr Phe Val Met Thr Ala Lys 
    290                 295                 300                 


Lys Gln Ser Leu Leu Asp Lys Gly Val Ile Leu His Asp Tyr Ala Asp 
305                 310                 315                 320 


Thr Glu Leu Leu Leu Ser Arg Glu Asn Val Asp Gln Glu Ala Leu Leu 
                325                 330                 335     


Ser Tyr Ala Arg Glu Ala Ala Asp Phe Ser Thr Gln Gln Gln Leu Pro 
            340                 345                 350         


Ser Leu Asp Phe Ala Ile Asn His Tyr Gly Gln Pro Asp Val Ala Met 
        355                 360                 365             


Phe Asp Phe Thr Cys Met Tyr Ala Ser Glu Asn Ala Ala Leu Val Arg 
    370                 375                 380                 


Glu Gln Asn Gly His Gln Leu Leu Val Ala Leu Val Gly Asp Ser Leu 
385                 390                 395                 400 


Leu Glu Pro Phe Trp Pro Met Gly Thr Gly Ile Ala Arg Gly Phe Leu 
                405                 410                 415     


Ala Ala Met Asp Ser Ala Trp Met Val Arg Ser Trp Ser Leu Gly Thr 
            420                 425                 430         


Ser Pro Leu Glu Val Leu Ala Glu Arg Glu Ser Ile Tyr Arg Leu Leu 
        435                 440                 445             


Pro Gln Thr Thr Pro Glu Asn Val Ser Lys Asn Phe Ser Gln Tyr Ser 
    450                 455                 460                 


Ile Asp Pro Val Thr Arg Tyr Pro Asn Ile Asn Val Asn Phe Leu Arg 
465                 470                 475                 480 


Pro Ser Gln Val Arg His Leu Tyr Asp Thr Gly Glu Thr Lys Asp Ile 
                485                 490                 495     


His Leu Glu Met Glu Ser Leu Val Asn Ser Arg Thr Thr Pro Lys Leu 
            500                 505                 510         


Thr Arg Asn Glu Ser Val Ala Arg Ser Ser Lys Leu Leu Gly Trp Cys 
        515                 520                 525             


Gln Arg Gln Thr Asp Gly Tyr Ala Gly Val Asn Val Thr Asp Leu Thr 
    530                 535                 540                 


Met Ser Trp Lys Ser Gly Leu Ala Leu Cys Ala Ile Ile His Arg Tyr 
545                 550                 555                 560 


Arg Pro Asp Leu Ile Asp Phe Asp Ser Leu Asp Glu Gln Asn Val Glu 
                565                 570                 575     


Lys Asn Asn Gln Leu Ala Phe Asp Ile Ala Glu Lys Glu Leu Gly Ile 
            580                 585                 590         


Ser Pro Ile Met Thr Gly Lys Glu Met Ala Ser Val Gly Glu Pro Asp 
        595                 600                 605             


Lys Leu Ser Met Val Met Tyr Leu Thr Gln Phe Tyr Glu Met Phe Lys 
    610                 615                 620                 


Asp Ser Leu Pro Ser Ser Asp Thr Leu Asp Leu Asn Ala Glu Glu Lys 
625                 630                 635                 640 


Ala Val Leu Ile Ala Ser Thr Arg Ser Pro Ile Ser Phe Leu Ser Lys 
                645                 650                 655     


Leu Gly Gln Thr Ile Ser Arg Lys Arg Ser Pro Lys Asp Lys Lys Glu 
            660                 665                 670         


Lys Asp Leu Asp Gly Ala Gly Lys Arg Arg Lys Thr Ser Gln Ser Glu 
        675                 680                 685             


Glu Glu Glu Ala Pro Arg Gly His Arg Gly Glu Arg Pro Thr Leu Val 
    690                 695                 700                 


Ser Thr Leu Thr Asp Arg Arg Met Asp Val Ala Val Gly Asn Gln Asn 
705                 710                 715                 720 


Lys Val Lys Tyr Met Ala Thr Gln Leu Leu Ala Lys Phe Glu Glu Asn 
                725                 730                 735     


Ala Pro Ala Gln Ser Ile Gly Ile Arg Arg Gln Gln Arg Glu Lys Glu 
            740                 745                 750         


Cys Ser Arg Thr Cys Pro Lys Lys Val Ile Thr Leu Ser Pro Pro Pro 
        755                 760                 765             


Thr Pro Pro Pro Cys Arg Ala His Gly Gly Gln Gln Thr Tyr Arg Asp 
    770                 775                 780                 


Leu Asp Ala Asp Asn Arg Gly Lys Gln Ser Pro His His Glu Arg Pro 
785                 790                 795                 800 


Glu Pro Glu Pro Pro Arg Arg Phe Phe Val Asp Gln Trp Glu Leu Ser 
                805                 810                 815     


Leu Ser Leu Arg Ser Ser Ala Arg Pro Ala Ser Pro Ser Ser Asp Ser 
            820                 825                 830         


Leu Arg Gln Lys Tyr Ile Lys Met Tyr Thr Gly Gly Val Ser Ser Leu 
        835                 840                 845             


Ala Glu Gln Ile Ala Asn Gln Leu Gln Arg Lys Glu Gln Pro Lys Ala 
    850                 855                 860                 


Leu Leu Asp Lys Lys Glu Leu Gly Ser Met Lys Lys Glu Phe Pro Gln 
865                 870                 875                 880 


Asn Leu Gly Gly Ser Asp Thr Cys Tyr Phe Cys Gln Lys Arg Val Tyr 
                885                 890                 895     


Val Met Glu Arg Leu Ser Ala Glu Gly Lys Phe Phe His Arg Ser Cys 
            900                 905                 910         


Phe Lys Cys Glu Tyr Cys Ala Thr Thr Leu Arg Leu Ser Ala Tyr Ala 
        915                 920                 925             


Tyr Asp Ile Glu Asp Gly Lys Phe Tyr Cys Lys Pro His Tyr Cys Tyr 
    930                 935                 940                 


Arg Leu Ser Gly Tyr Ala Gln Arg Lys Arg Pro Ala Val Ala Pro Leu 
945                 950                 955                 960 


Ser Gly Lys Glu Ala Lys Gly Pro Leu Gln Asp Gly Ala Thr Thr Asp 
                965                 970                 975     


Ala Asn Gly Arg Ala Asn Ala Val Ala Ser Ser Thr Glu Arg Thr Pro 
            980                 985                 990         


Gly Ser Leu Thr Ser Leu Phe Gly  Trp Val Ala Arg His  Ser Leu Gly 
        995                 1000                 1005             


Leu Cys  Asp Lys Ala Lys Gly  Met Ser Gln His Leu  Gln Ser Asn 
    1010                 1015                 1020             


Ile Ser  Ser Phe Gly Gln Gln  Val Ala Gln Asn Pro  Leu Asp Ser 
    1025                 1030                 1035             


Phe Phe  Met Cys Gln Leu Leu  Ala Phe Gly Val Pro  Phe Leu Tyr 
    1040                 1045                 1050             


Gly Leu  Ser Glu Val Leu Val  Gln Ile Arg Gly Glu  Phe His Trp 
    1055                 1060                 1065             


Gln Ala  Val Ala Gln 
    1070             


<210> 7598
<211> 180
<212> PRT
<213> Homo sapiens

<400> 7598
Met Phe Leu Ser Cys Gly Ser Leu His Gln Arg Gly Pro Glu Thr Asp 
1               5                   10                  15      


Gly Thr Val Phe Arg Ile His Thr Lys Ala Glu Gly Phe Met Asp Val 
            20                  25                  30          


Asp Ile Pro Leu Glu Leu Val Phe His Leu Pro Val Asn Tyr Pro Ser 
        35                  40                  45              


Cys Leu Pro Gly Ile Ser Ile Asn Ser Glu Gln Leu Thr Arg Ala Gln 
    50                  55                  60                  


Cys Val Thr Val Lys Glu Asn Leu Leu Glu Gln Ala Glu Ser Leu Leu 
65                  70                  75                  80  


Ser Glu Pro Met Val His Glu Leu Val Leu Trp Ile Gln Gln Asn Leu 
                85                  90                  95      


Arg His Ile Leu Ser Gln Pro Glu Thr Gly Ser Gly Ser Glu Lys Cys 
            100                 105                 110         


Thr Phe Ser Thr Ser Thr Thr Met Asp Asp Gly Leu Trp Ile Thr Leu 
        115                 120                 125             


Leu His Leu Asp His Met Arg Ala Lys Thr Lys Tyr Val Lys Ile Val 
    130                 135                 140                 


Glu Lys Trp Ala Ser Asp Leu Arg Leu Thr Gly Arg Leu Met Phe Met 
145                 150                 155                 160 


Gly Lys Ile Ile Leu Ile Leu Leu Gln Gly Asp Arg Asn Asn Leu Lys 
                165                 170                 175     


Val Pro Lys Ser 
            180 


<210> 7599
<211> 506
<212> PRT
<213> Homo sapiens

<400> 7599
Met Lys Arg Arg Ser Val Thr Met Thr Asp Gly Leu Thr Ala Asp Lys 
1               5                   10                  15      


Val Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr Ser Leu Pro Arg Pro 
            20                  25                  30          


Arg Asp Ser Ile Arg Ser Cys Ala Leu Ser Met Asp Gln Ile Pro Asp 
        35                  40                  45              


Leu His Ser Pro Met Ser Pro Ile Ser Glu Ser Pro Ser Ser Pro Ala 
    50                  55                  60                  


Tyr Ser Thr Val Thr Arg Val His Ala Ala Pro Ala Ala Pro Ser Ala 
65                  70                  75                  80  


Thr Ala Leu Pro Ala Ser Pro Val Ala Arg Arg Ser Ser Glu Pro Gln 
                85                  90                  95      


Leu Cys Pro Gly Ser Ala Pro Lys Thr His Gly Glu Ser Asp Lys Gly 
            100                 105                 110         


Pro His Thr Ser Pro Ser His Thr Leu Gly Lys Ala Ser Pro Ser Pro 
        115                 120                 125             


Ser Leu Ser Ser Tyr Ser Asp Pro Asp Ser Gly His Tyr Cys Gln Leu 
    130                 135                 140                 


Gln Pro Pro Val Arg Gly Ser Arg Glu Trp Ala Ala Thr Glu Thr Ser 
145                 150                 155                 160 


Ser Gln Gln Ala Arg Ser Tyr Gly Glu Arg Leu Lys Glu Leu Ser Glu 
                165                 170                 175     


Asn Gly Ala Pro Glu Gly Asp Trp Gly Lys Thr Phe Thr Val Pro Ile 
            180                 185                 190         


Val Glu Val Thr Ser Ser Phe Asn Pro Ala Thr Phe Gln Ser Leu Leu 
        195                 200                 205             


Ile Pro Arg Asp Asn Arg Pro Leu Glu Val Gly Leu Leu Arg Lys Val 
    210                 215                 220                 


Lys Glu Leu Leu Ala Glu Val Asp Ala Arg Thr Leu Ala Arg His Val 
225                 230                 235                 240 


Thr Lys Val Asp Cys Leu Val Ala Arg Ile Leu Gly Val Thr Lys Glu 
                245                 250                 255     


Met Gln Thr Leu Met Gly Val Arg Trp Gly Met Glu Leu Leu Thr Leu 
            260                 265                 270         


Pro His Gly Arg Gln Leu Arg Leu Asp Leu Leu Glu Arg Phe His Thr 
        275                 280                 285             


Met Ser Ile Met Leu Ala Val Asp Ile Leu Gly Cys Thr Gly Ser Ala 
    290                 295                 300                 


Glu Glu Arg Ala Ala Leu Leu His Lys Thr Ile Gln Leu Ala Ala Glu 
305                 310                 315                 320 


Leu Arg Gly Thr Met Gly Asn Met Phe Ser Phe Ala Ala Val Met Gly 
                325                 330                 335     


Ala Leu Asp Met Ala Gln Ile Ser Arg Leu Glu Gln Thr Trp Val Thr 
            340                 345                 350         


Leu Arg Gln Arg His Thr Glu Gly Ala Ile Leu Tyr Glu Lys Lys Leu 
        355                 360                 365             


Lys Pro Phe Leu Lys Ser Leu Asn Glu Gly Lys Glu Gly Pro Pro Leu 
    370                 375                 380                 


Ser Asn Thr Thr Phe Pro His Val Leu Pro Leu Ile Thr Leu Leu Glu 
385                 390                 395                 400 


Cys Asp Ser Ala Pro Pro Glu Gly Pro Glu Pro Trp Gly Ser Thr Glu 
                405                 410                 415     


His Gly Val Glu Val Val Leu Ala His Leu Glu Ala Ala Arg Thr Val 
            420                 425                 430         


Ala His His Gly Gly Leu Tyr His Thr Asn Ala Glu Val Lys Leu Gln 
        435                 440                 445             


Gly Phe Gln Ala Arg Pro Glu Leu Leu Glu Val Phe Ser Thr Glu Phe 
    450                 455                 460                 


Gln Met Arg Leu Leu Trp Gly Ser Gln Gly Ala Ser Ser Ser Gln Ala 
465                 470                 475                 480 


Arg Arg Tyr Glu Lys Phe Asp Lys Val Leu Thr Ala Leu Ser His Lys 
                485                 490                 495     


Leu Glu Pro Ala Val Arg Ser Ser Glu Leu 
            500                 505     


<210> 7600
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7600
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7601
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7601
Met Pro Glu Ile Asn Thr Asn His Leu Asp Lys Gln Gln Val Gln Leu 
1               5                   10                  15      


Leu Ala Glu Met Cys Ile Leu Ile Asp Glu Asn Asp Asn Lys Ile Gly 
            20                  25                  30          


Ala Glu Thr Lys Lys Asn Cys His Leu Asn Glu Asn Ile Glu Lys Gly 
        35                  40                  45              


Leu Leu His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr Glu Asn Lys 
    50                  55                  60                  


Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe Pro Gly Cys 
65                  70                  75                  80  


Phe Thr Asn Thr Cys Cys Ser His Pro Leu Ser Asn Pro Ala Glu Leu 
                85                  90                  95      


Glu Glu Ser Asp Ala Leu Gly Val Arg Arg Ala Ala Gln Arg Arg Leu 
            100                 105                 110         


Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu 
        115                 120         


<210> 7602
<211> 135
<212> PRT
<213> Homo sapiens

<400> 7602
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210> 7603
<211> 1093
<212> PRT
<213> Homo sapiens

<400> 7603
Met Gly Thr Gly Asp Phe Ile Cys Ile Ser Met Thr Gly Gly Ala Pro 
1               5                   10                  15      


Trp Gly Phe Arg Leu Gln Gly Gly Lys Glu Gln Lys Gln Pro Leu Gln 
            20                  25                  30          


Val Ala Lys Ile Arg Asn Gln Ser Lys Ala Ser Gly Ser Gly Leu Cys 
        35                  40                  45              


Glu Gly Asp Glu Val Val Ser Ile Asn Gly Asn Pro Cys Ala Asp Leu 
    50                  55                  60                  


Thr Tyr Pro Glu Val Ile Lys Leu Met Glu Ser Ile Thr Asp Ser Leu 
65                  70                  75                  80  


Gln Met Leu Ile Lys Arg Pro Ser Ser Gly Ile Ser Glu Ala Leu Ile 
                85                  90                  95      


Ser Glu Asn Glu Asn Lys Asn Leu Glu His Leu Thr His Gly Gly Tyr 
            100                 105                 110         


Val Glu Ser Thr Thr Leu Gln Ile Arg Pro Ala Thr Lys Thr Gln Cys 
        115                 120                 125             


Thr Glu Phe Phe Leu Ala Pro Val Lys Thr Glu Val Pro Leu Ala Glu 
    130                 135                 140                 


Asn Gln Arg Ser Gly Pro Asp Cys Ala Gly Ser Leu Lys Glu Glu Thr 
145                 150                 155                 160 


Gly Pro Ser Tyr Gln Arg Ala Pro Gln Met Pro Asp Ser Gln Arg Gly 
                165                 170                 175     


Arg Val Ala Glu Glu Leu Ile Leu Arg Glu Lys Val Glu Ala Val Gln 
            180                 185                 190         


Pro Gly Pro Val Val Glu Leu Gln Leu Ser Leu Ser Gln Glu Arg His 
        195                 200                 205             


Lys Gly Ala Ser Gly Pro Leu Val Ala Leu Pro Gly Ala Glu Lys Ser 
    210                 215                 220                 


Lys Ser Pro Asp Pro Asp Pro Asn Leu Ser His Asp Arg Ile Val His 
225                 230                 235                 240 


Ile Asn Ser Ile Pro Thr Asn Glu Lys Ala Asp Pro Phe Leu Arg Ser 
                245                 250                 255     


Ser Lys Ile Ile Gln Ile Ser Ser Gly Arg Glu Leu Arg Val Ile Gln 
            260                 265                 270         


Glu Ser Glu Ala Gly Asp Ala Gly Leu Pro Arg Val Glu Val Ile Leu 
        275                 280                 285             


Asp Cys Ser Asp Arg Gln Lys Thr Glu Gly Cys Arg Leu Gln Ala Gly 
    290                 295                 300                 


Lys Glu Cys Val Asp Ser Pro Val Glu Gly Gly Gln Ser Glu Ala Pro 
305                 310                 315                 320 


Pro Ser Leu Val Ser Phe Ala Val Ser Ser Glu Gly Thr Glu Gln Gly 
                325                 330                 335     


Glu Asp Pro Arg Ser Glu Lys Asp His Ser Arg Pro His Lys His Arg 
            340                 345                 350         


Ala Arg His Ala Arg Leu Arg Arg Ser Glu Ser Leu Ser Glu Lys Gln 
        355                 360                 365             


Val Lys Glu Ala Lys Ser Lys Cys Lys Ser Ile Ala Leu Leu Leu Thr 
    370                 375                 380                 


Asp Ala Pro Asn Pro Asn Ser Lys Gly Val Leu Met Phe Lys Lys Arg 
385                 390                 395                 400 


Arg Arg Arg Ala Arg Lys Tyr Thr Leu Val Ser Tyr Gly Thr Gly Glu 
                405                 410                 415     


Leu Glu Arg Glu Ala Asp Glu Glu Glu Glu Gly Asp Lys Glu Asp Thr 
            420                 425                 430         


Cys Glu Val Ala Phe Leu Gly Ala Ser Glu Ser Glu Val Asp Glu Glu 
        435                 440                 445             


Leu Leu Ser Asp Val Asp Asp Asn Thr Gln Val Val Asn Phe Asp Trp 
    450                 455                 460                 


Asp Ser Gly Leu Val Asp Ile Glu Lys Lys Leu Asn Arg Gly Asp Lys 
465                 470                 475                 480 


Met Glu Met Leu Pro Asp Thr Thr Gly Lys Gly Ala Leu Met Phe Ala 
                485                 490                 495     


Lys Arg Arg Glu Arg Met Asp Gln Ile Thr Ala Gln Lys Glu Glu Asp 
            500                 505                 510         


Lys Val Gly Gly Thr Pro Ser Arg Glu Gln Asp Ala Ala Gln Thr Asp 
        515                 520                 525             


Gly Leu Arg Thr Thr Thr Ser Tyr Gln Arg Lys Glu Glu Glu Ser Val 
    530                 535                 540                 


Arg Thr Gln Ser Ser Val Ser Lys Ser Tyr Ile Glu Val Ser His Gly 
545                 550                 555                 560 


Leu Gly His Val Pro Gln Gln Asn Gly Phe Ser Gly Thr Ser Glu Thr 
                565                 570                 575     


Ala Asn Ile Gln Arg Met Val Pro Met Asn Arg Thr Ala Lys Pro Phe 
            580                 585                 590         


Pro Gly Ser Val Asn Gln Pro Ala Thr Pro Phe Ser Pro Thr Arg Asn 
        595                 600                 605             


Met Thr Ser Pro Ile Ala Asp Phe Pro Ala Pro Pro Pro Tyr Ser Ala 
    610                 615                 620                 


Val Thr Pro Pro Pro Asp Ala Phe Ser Arg Gly Val Ser Ser Pro Ile 
625                 630                 635                 640 


Ala Gly Pro Ala Gln Pro Pro Pro Trp Pro Gln Pro Ala Pro Trp Ser 
                645                 650                 655     


Gln Pro Ala Phe Tyr Asp Ser Ser Glu Arg Ile Ala Ser Arg Asp Glu 
            660                 665                 670         


Arg Ile Ser Val Pro Ala Lys Arg Thr Gly Ile Leu Gln Glu Ala Lys 
        675                 680                 685             


Arg Arg Ser Thr Thr Lys Pro Met Phe Thr Phe Lys Glu Pro Lys Val 
    690                 695                 700                 


Ser Pro Asn Pro Glu Leu Leu Ser Leu Leu Gln Asn Ser Glu Gly Lys 
705                 710                 715                 720 


Arg Gly Thr Gly Ala Gly Gly Asp Ser Gly Pro Glu Glu Asp Tyr Leu 
                725                 730                 735     


Ser Leu Gly Ala Glu Ala Cys Asn Phe Met Gln Ser Ser Ser Ala Lys 
            740                 745                 750         


Gln Lys Thr Pro Pro Pro Val Ala Pro Lys Pro Ala Val Lys Ser Ser 
        755                 760                 765             


Ser Ser Gln Pro Val Thr Pro Val Ser Pro Val Trp Ser Pro Gly Val 
    770                 775                 780                 


Ala Pro Thr Gln Pro Pro Ala Phe Pro Thr Ser Asn Pro Ser Lys Gly 
785                 790                 795                 800 


Thr Val Val Ser Ser Ile Lys Ile Ala Gln Pro Ser Tyr Pro Pro Ala 
                805                 810                 815     


Arg Pro Ala Ser Thr Leu Asn Val Ala Gly Pro Phe Lys Gly Pro Gln 
            820                 825                 830         


Ala Ala Val Ala Ser Gln Asn Tyr Thr Pro Lys Pro Thr Val Ser Thr 
        835                 840                 845             


Pro Thr Val Asn Ala Val Gln Pro Gly Ala Val Gly Pro Ser Asn Glu 
    850                 855                 860                 


Leu Pro Gly Met Ser Gly Arg Gly Ala Gln Leu Phe Ala Lys Arg Gln 
865                 870                 875                 880 


Ser Arg Met Glu Lys Tyr Val Val Asp Ser Asp Thr Val Gln Ala His 
                885                 890                 895     


Ala Ala Arg Ala Gln Ser Pro Thr Pro Ser Leu Pro Ala Ser Trp Lys 
            900                 905                 910         


Tyr Ser Ser Asn Val Arg Ala Pro Pro Pro Val Ala Tyr Asn Pro Ile 
        915                 920                 925             


His Ser Pro Ser Tyr Pro Leu Ala Ala Leu Lys Ser Gln Pro Ser Ala 
    930                 935                 940                 


Ala Gln Pro Ser Lys Met Gly Lys Lys Lys Gly Lys Lys Pro Leu Asn 
945                 950                 955                 960 


Ala Leu Asp Val Met Lys His Gln Pro Tyr Gln Leu Asn Ala Ser Leu 
                965                 970                 975     


Phe Thr Phe Gln Pro Pro Asp Ala Lys Asp Gly Leu Pro Gln Lys Ser 
            980                 985                 990         


Ser Val Lys Val Asn Ser Ala Leu  Ala Met Lys Gln Ala  Leu Pro Pro 
        995                 1000                 1005             


Arg Pro  Val Asn Ala Ala Ser  Pro Thr Asn Val Gln  Ala Ser Ser 
    1010                 1015                 1020             


Val Tyr  Ser Val Pro Ala Tyr  Thr Ser Pro Pro Ser  Phe Phe Ala 
    1025                 1030                 1035             


Glu Ala  Ser Ser Pro Val Ser  Ala Ser Pro Val Pro  Val Gly Ile 
    1040                 1045                 1050             


Pro Thr  Ser Pro Lys Gln Glu  Ser Ala Ser Ser Ser  Tyr Phe Val 
    1055                 1060                 1065             


Ala Pro  Arg Pro Lys Phe Ser  Ala Lys Lys Ser Gly  Val Thr Ile 
    1070                 1075                 1080             


Gln Val  Trp Lys Pro Ser Val  Val Glu Glu 
    1085                 1090             


<210> 7604
<211> 199
<212> PRT
<213> Homo sapiens

<400> 7604
Met Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser Val Ser Ser Leu 
            20                  25                  30          


Ile Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His 
        35                  40                  45              


Gly Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp Gly Leu Leu Arg 
    50                  55                  60                  


Gly Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala Val Pro Pro Arg 
65                  70                  75                  80  


Lys Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn Glu Asp Phe Arg 
                85                  90                  95      


Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu 
            100                 105                 110         


Gln Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu Ile 
        115                 120                 125             


Pro Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys Ile Leu Ile Arg 
    130                 135                 140                 


Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser 
145                 150                 155                 160 


Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gln 
                165                 170                 175     


Gly Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser Ser Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ala Ala 
        195                 


<210> 7605
<211> 203
<212> PRT
<213> Homo sapiens

<400> 7605
Met Pro Ser Thr Pro Ala Ser Thr Ile Ser Ala Arg Glu Glu Leu Val 
1               5                   10                  15      


Gln Arg Ile Pro Glu Ala Ser Leu Asn Phe Gln Lys Val Pro Pro Gly 
            20                  25                  30          


Ser Leu Asn Ser Arg Asp Phe Asp Gln Asn Met Asn Asp Ser Cys Glu 
        35                  40                  45              


Asp Ala Leu Ala Asn Lys Thr Arg Pro Arg Asn Arg Glu Glu Val Ile 
    50                  55                  60                  


Phe Asp Asn Leu Met Leu Asn Pro Val Ser Gln Leu Ser Gln Ala Ile 
65                  70                  75                  80  


Arg Glu Asn Thr Glu His Leu Ala Glu Lys Met Lys Ile Leu Phe Gln 
                85                  90                  95      


Asn Thr Gly Arg Ala Trp Glu Asp Leu Glu Ala Arg Ile Asn Ala Glu 
            100                 105                 110         


Asn Glu Val Pro Ile Leu Lys Thr Ser Asn Lys Glu Ile Ser Ser Ile 
        115                 120                 125             


Leu Lys Glu Leu Arg Arg Val Gln Lys Gln Leu Glu Val Ile Asn Ala 
    130                 135                 140                 


Ile Val Asp Pro Ser Gly Ser Leu Asp Leu Leu Leu Pro Thr Leu Ser 
145                 150                 155                 160 


Ser Phe Val Pro Pro Pro Pro Ala Phe Ala Trp Glu Leu Val Leu Val 
                165                 170                 175     


Cys Arg Ala Ser Arg Arg Val His Cys Thr Phe Val Leu Arg Trp Ser 
            180                 185                 190         


Cys Gly Cys Leu Ser Glu Asn Gly Tyr Phe Ile 
        195                 200             


<210> 7606
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7606
Xaa Pro Thr Thr Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Thr Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Thr Lys Ser Pro Ala Ile Ile Asp Ser Asp 
    50                  55                  60                  


Pro Val Asp Glu Glu Val Leu Met Ser Leu Val Val Glu Leu Gly Leu 
65                  70                  75                  80  


Asp Arg Ala Asn Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe 
                85                  90                  95      


Asp Phe Thr Ala Asp Phe Pro Ser Ser Cys 
            100                 105     


<210> 7607
<211> 151
<212> PRT
<213> Homo sapiens

<400> 7607
Met Ala Ala Phe Arg Asp Ile Glu Glu Val Ser Gln Gly Leu Leu Ser 
1               5                   10                  15      


Leu Leu Gly Ala Asn Arg Ala Glu Ala Gln Gln Arg Arg Leu Leu Gly 
            20                  25                  30          


Arg His Glu Gln Val Val Glu Arg Leu Leu Glu Thr Gln Asp Gly Ala 
        35                  40                  45              


Glu Lys Gln Leu Arg Glu Ile Leu Thr Met Glu Lys Glu Val Ala Gln 
    50                  55                  60                  


Ser Leu Leu Asn Ala Lys Glu Gln Glu Arg Gln Glu Lys Glu Val Asp 
65                  70                  75                  80  


Glu Asp Thr Thr Val Thr Ile Pro Ser Ala Val Tyr Val Ala Gln Leu 
                85                  90                  95      


Tyr His Gln Val Ser Lys Ile Glu Trp Asp Tyr Glu Cys Glu Pro Gly 
            100                 105                 110         


Met Val Lys Gly Ile His His Gly Pro Ser Val Ala Gln Pro Ile His 
        115                 120                 125             


Leu Asp Ser Thr Gln Leu Ser Arg Lys Phe Ile Ser Asp Tyr Leu Trp 
    130                 135                 140                 


Ser Leu Val Asp Thr Glu Trp 
145                 150     


<210> 7608
<211> 147
<212> PRT
<213> Homo sapiens

<400> 7608
Met Leu Arg Cys Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg 
1               5                   10                  15      


His Leu Gly Arg Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp 
            20                  25                  30          


Ser Tyr Phe Ser Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr 
        35                  40                  45              


Tyr Ser Ile His Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser 
    50                  55                  60                  


Ile Gly Gln Trp Tyr Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys 
65                  70                  75                  80  


Leu Ala Val Phe Asp Thr Trp Ser Ser Leu Ala Val His Ile Ala Met 
                85                  90                  95      


Asp Asn Thr Val Val Met Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser 
            100                 105                 110         


Val Pro Cys Ala Gly Ala Thr Ala Phe Pro Ala Asp Ser Asp Arg His 
        115                 120                 125             


Cys Asn Gly Phe Pro Ala Gly Ala Glu Val Thr Asn Arg Pro Ser Pro 
    130                 135                 140                 


Trp Arg Pro 
145         


<210> 7609
<211> 493
<212> PRT
<213> Homo sapiens

<400> 7609
Met Glu Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Met Val Met Lys Cys Arg Asn Lys Asp Thr Gly Arg Ile Val Ala Ile 
            20                  25                  30          


Lys Lys Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala 
        35                  40                  45              


Met Arg Glu Ile Lys Leu Leu Lys Gln Leu Arg His Glu Asn Leu Val 
    50                  55                  60                  


Asn Leu Leu Glu Val Cys Lys Lys Lys Lys Arg Trp Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Val Asp His Thr Ile Leu Asp Asp Leu Glu Leu Phe Pro Asn 
                85                  90                  95      


Gly Leu Asp Tyr Gln Val Val Gln Lys Tyr Leu Phe Gln Ile Ile Asn 
            100                 105                 110         


Gly Ile Gly Phe Cys His Ser His Asn Ile Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Val Ser Gln Ser Gly Val Val Lys Leu Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Glu Val Tyr Thr Asp 
145                 150                 155                 160 


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp 
                165                 170                 175     


Val Lys Tyr Gly Lys Ala Val Asp Val Trp Ala Ile Gly Cys Leu Val 
            180                 185                 190         


Thr Glu Met Phe Met Gly Glu Pro Leu Phe Pro Gly Asp Ser Asp Ile 
        195                 200                 205             


Asp Gln Leu Tyr His Ile Met Met Cys Leu Gly Asn Leu Ile Pro Arg 
    210                 215                 220                 


His Gln Glu Leu Phe Asn Lys Asn Pro Val Phe Ala Gly Val Arg Leu 
225                 230                 235                 240 


Pro Glu Ile Lys Glu Arg Glu Pro Leu Glu Arg Arg Tyr Pro Lys Leu 
                245                 250                 255     


Ser Glu Val Val Ile Asp Leu Ala Lys Lys Cys Leu His Ile Asp Pro 
            260                 265                 270         


Asp Lys Arg Pro Phe Cys Ala Glu Leu Leu His His Asp Phe Phe Gln 
        275                 280                 285             


Met Asp Gly Phe Ala Glu Arg Phe Ser Gln Glu Leu Gln Leu Lys Val 
    290                 295                 300                 


Gln Lys Asp Ala Arg Asn Val Ser Leu Ser Lys Lys Ser Gln Asn Arg 
305                 310                 315                 320 


Lys Lys Glu Lys Glu Lys Asp Asp Ser Leu Val Glu Glu Arg Lys Thr 
                325                 330                 335     


Leu Val Val Gln Asp Thr Asn Ala Asp Pro Lys Ile Lys Asp Tyr Lys 
            340                 345                 350         


Leu Phe Lys Ile Lys Gly Ser Lys Ile Asp Gly Glu Lys Ala Glu Lys 
        355                 360                 365             


Gly Asn Arg Ala Ser Asn Ala Ser Cys Leu His Asp Ser Arg Thr Ser 
    370                 375                 380                 


His Asn Lys Ile Val Pro Ser Thr Ser Leu Lys Asp Cys Ser Asn Val 
385                 390                 395                 400 


Ser Val Asp His Thr Arg Asn Pro Ser Val Ala Ile Pro Pro Leu Thr 
                405                 410                 415     


His Asn Leu Ser Ala Val Ala Pro Ser Ile Asn Ser Gly Met Gly Thr 
            420                 425                 430         


Glu Thr Ile Pro Ile Gln Gly Tyr Arg Val Asp Glu Lys Thr Lys Lys 
        435                 440                 445             


Cys Ser Ile Pro Phe Val Lys Pro Asn Arg His Ser Pro Ser Gly Ile 
    450                 455                 460                 


Tyr Asn Ile Asn Val Thr Thr Leu Val Ser Gly Pro Pro Leu Ser Asp 
465                 470                 475                 480 


Asp Ser Gly Ala Asp Leu Pro Gln Met Glu His Gln His 
                485                 490             


<210> 7610
<211> 2062
<212> PRT
<213> Homo sapiens

<400> 7610
Met Asp Gly Cys Leu Asp Thr Glu Thr Pro Thr Val Ser Ile Gln Glu 
1               5                   10                  15      


Asn Val Asp Val Ala Ser Leu Lys Pro Ile Ser Asp Ser Gly Ile Asn 
            20                  25                  30          


Phe Thr Asp Ala Ile Trp Ser Pro Thr Cys Glu Arg Arg Thr Cys Glu 
        35                  40                  45              


Cys His Glu Ser Ile Glu Lys Asn Lys Asp Lys Thr Asp Leu Pro Gln 
    50                  55                  60                  


Ser Val Val Tyr Gln Asn Glu Glu Gly Arg Trp Val Thr Asp Leu Ala 
65                  70                  75                  80  


Tyr Tyr Thr Ser Phe Asn Ser Lys Gln Asn Leu Asn Val Ser Leu Ser 
                85                  90                  95      


Asp Glu Met Asn Glu Asp Phe Arg Ser Gly Ser Glu Ala Phe Asp Leu 
            100                 105                 110         


Ile Ala Gln Asp Glu Glu Glu Phe Asn Lys Glu His Gln Phe Ile Gln 
        115                 120                 125             


Pro Ser Phe Gly Tyr Phe Ile Arg Ser Pro Glu Lys Arg Glu Pro Ile 
    130                 135                 140                 


Ala Leu Ile Arg Lys Ser Asp Val Ser Arg Gly Asn Leu Glu Lys Glu 
145                 150                 155                 160 


Met Ala His Leu Asn His Asp Leu Tyr Ser Gly Asp Leu Asn Glu Gln 
                165                 170                 175     


Ser Gln Ala Gln Leu Ser Glu Gly Ser Ile Thr Leu Gln Val Glu Ala 
            180                 185                 190         


Val Glu Ser Thr Ser Gln Val Asp Glu Asn Asp Val Thr Leu Thr Ala 
        195                 200                 205             


Asp Lys Gly Lys Thr Glu Asp Thr Phe Phe Met Ser Asn Lys Pro Gln 
    210                 215                 220                 


Arg Tyr Lys Asp Lys Leu Pro Asp Ser Gly Asp Ser Met Leu Arg Ile 
225                 230                 235                 240 


Ser Thr Ile Ala Ser Ala Ile Ala Glu Ala Ser Val Asn Thr Asp Pro 
                245                 250                 255     


Ser Gln Leu Ala Ala Met Ile Lys Ala Leu Ser Asn Lys Thr Arg Asp 
            260                 265                 270         


Lys Thr Phe Gln Glu Asp Glu Lys Gln Lys Asp Tyr Ser His Val Arg 
        275                 280                 285             


His Phe Leu Pro Asn Asp Leu Glu Lys Ser Asn Gly Ser Asn Ala Leu 
    290                 295                 300                 


Asp Met Glu Lys Tyr Leu Lys Lys Thr Glu Val Ser Arg Tyr Glu Ser 
305                 310                 315                 320 


Ala Leu Glu Asn Phe Ser Arg Ala Ser Met Ser Asp Thr Trp Asp Leu 
                325                 330                 335     


Ser Leu Pro Lys Glu Gln Thr Thr Gln Asp Ile His Pro Val Asp Leu 
            340                 345                 350         


Ser Ala Thr Ser Val Ser Val Arg Ala Pro Glu Glu Asn Thr Ala Ala 
        355                 360                 365             


Ile Val Tyr Val Glu Asn Gly Glu Ser Glu Asn Gln Glu Ser Phe Arg 
    370                 375                 380                 


Thr Ile Asn Ser Ser Asn Ser Val Thr Asn Arg Glu Asn Asn Ser Ala 
385                 390                 395                 400 


Val Val Asp Val Lys Thr Cys Ser Ile Asp Asn Lys Leu Gln Asp Val 
                405                 410                 415     


Gly Asn Asp Glu Lys Ala Thr Ser Ile Ser Thr Pro Ser Asp Ser Tyr 
            420                 425                 430         


Ser Ser Val Arg Asn Pro Arg Ile Thr Ser Leu Cys Leu Leu Lys Asp 
        435                 440                 445             


Cys Glu Glu Ile Arg Asp Asn Arg Glu Asn Gln Arg Gln Asn Glu Cys 
    450                 455                 460                 


Val Ser Glu Ile Ser Asn Ser Glu Lys His Val Thr Phe Glu Asn His 
465                 470                 475                 480 


Arg Ile Val Ser Pro Lys Asn Ser Asp Leu Lys Asn Thr Ser Pro Glu 
                485                 490                 495     


His Gly Gly Arg Gly Ser Glu Asp Glu Gln Glu Ser Phe Arg Pro Ser 
            500                 505                 510         


Thr Ser Pro Leu Ser His Ser Ser Pro Ser Glu Ile Ser Gly Thr Ser 
        515                 520                 525             


Ser Ser Gly Cys Ala Leu Glu Ser Phe Gly Ser Ala Ala Gln Gln Gln 
    530                 535                 540                 


Gln Pro Pro Cys Glu Gln Glu Leu Ser Pro Leu Val Cys Ser Pro Ala 
545                 550                 555                 560 


Gly Val Ser Arg Leu Thr Tyr Val Ser Glu Pro Glu Ser Ser Tyr Pro 
                565                 570                 575     


Thr Thr Ala Thr Asp Asp Ala Leu Glu Asp Arg Lys Ser Asp Ile Thr 
            580                 585                 590         


Ser Glu Leu Ser Thr Thr Ile Ile Gln Gly Ser Pro Ala Ala Leu Glu 
        595                 600                 605             


Glu Arg Ala Met Glu Lys Leu Arg Glu Lys Val Pro Phe Gln Asn Arg 
    610                 615                 620                 


Gly Lys Gly Thr Leu Ser Ser Ile Ile Gln Asn Asn Ser Asp Thr Arg 
625                 630                 635                 640 


Lys Ala Thr Glu Thr Thr Ser Leu Ser Ser Lys Pro Glu Tyr Val Lys 
                645                 650                 655     


Pro Asp Phe Arg Trp Ser Lys Asp Pro Ser Ser Lys Ser Gly Asn Leu 
            660                 665                 670         


Leu Glu Thr Ser Glu Val Gly Trp Thr Ser Asn Pro Glu Glu Leu Asp 
        675                 680                 685             


Pro Ile Arg Leu Ala Leu Leu Gly Lys Ser Gly Leu Ser Cys Gln Val 
    690                 695                 700                 


Gly Ser Ala Thr Ser His Pro Val Ser Cys Gln Glu Pro Ile Asp Glu 
705                 710                 715                 720 


Asp Gln Arg Ile Ser Pro Lys Asp Lys Ser Thr Ala Gly Arg Glu Phe 
                725                 730                 735     


Ser Gly Gln Val Ser His Gln Thr Thr Ser Glu Asn Gln Cys Thr Pro 
            740                 745                 750         


Ile Pro Ser Ser Thr Val His Ser Ser Val Ala Asp Met Gln Asn Met 
        755                 760                 765             


Pro Ala Ala Val His Ala Leu Leu Thr Gln Pro Ser Leu Ser Ala Ala 
    770                 775                 780                 


Pro Phe Ala Gln Arg Tyr Leu Gly Thr Leu Pro Ser Thr Gly Ser Thr 
785                 790                 795                 800 


Thr Leu Pro Gln Cys His Ala Gly Asn Ala Thr Val Cys Gly Phe Ser 
                805                 810                 815     


Gly Gly Leu Pro Tyr Pro Ala Val Ala Gly Glu Pro Val Gln Asn Ser 
            820                 825                 830         


Val Ala Val Gly Ile Cys Leu Gly Ser Asn Ile Gly Ser Gly Trp Met 
        835                 840                 845             


Gly Thr Ser Ser Leu Cys Asn Pro Tyr Ser Asn Thr Leu Asn Gln Asn 
    850                 855                 860                 


Leu Leu Ser Thr Thr Lys Pro Phe Pro Val Pro Ser Val Gly Thr Asn 
865                 870                 875                 880 


Cys Gly Ile Glu Pro Trp Asp Ser Gly Val Thr Ser Gly Leu Gly Ser 
                885                 890                 895     


Val Arg Val Pro Glu Glu Leu Lys Leu Pro His Ala Cys Cys Val Gly 
            900                 905                 910         


Ile Ala Ser Gln Thr Leu Leu Ser Val Leu Asn Pro Thr Asp Arg Trp 
        915                 920                 925             


Leu Gln Val Ser Ile Gly Val Leu Ser Ile Ser Val Asn Gly Glu Lys 
    930                 935                 940                 


Val Asp Leu Ser Thr Tyr Arg Cys Leu Val Phe Lys Asn Lys Ala Ile 
945                 950                 955                 960 


Ile Arg Pro His Ala Thr Glu Glu Ile Lys Val Leu Phe Ile Pro Ser 
                965                 970                 975     


Ser Pro Gly Val Phe Arg Cys Thr Phe Ser Val Ala Ser Trp Pro Cys 
            980                 985                 990         


Ser Thr Asp Ala Glu Thr Ile Val  Gln Ala Glu Ala Leu  Ala Ser Thr 
        995                 1000                 1005             


Val Thr  Leu Thr Ala Ile Ala  Glu Ser Pro Val Ile  Glu Val Glu 
    1010                 1015                 1020             


Thr Glu  Lys Lys Asp Val Leu  Asp Phe Gly Asp Leu  Thr Tyr Gly 
    1025                 1030                 1035             


Gly Trp  Lys Ala Leu Pro Leu  Lys Leu Ile Asn Arg  Thr His Ala 
    1040                 1045                 1050             


Thr Val  Pro Ile Arg Leu Ile  Ile Asn Ala Asn Ala  Val Ala Trp 
    1055                 1060                 1065             


Arg Cys  Phe Thr Phe Ser Lys  Glu Ser Val Arg Ala  Pro Val Glu 
    1070                 1075                 1080             


Val Ala  Pro Cys Ala Asp Val  Val Thr Arg Leu Ala  Gly Pro Ser 
    1085                 1090                 1095             


Val Val  Asn His Met Met Pro  Ala Ser Tyr Asp Gly  Gln Asp Pro 
    1100                 1105                 1110             


Glu Phe  Leu Met Ile Trp Val  Leu Phe His Ser Pro  Lys Lys Gln 
    1115                 1120                 1125             


Ile Ser  Ser Ser Asp Ile Leu  Asp Ser Ala Glu Glu  Phe Ser Ala 
    1130                 1135                 1140             


Lys Val  Asp Ile Glu Val Asp  Ser Pro Asn Pro Thr  Pro Val Leu 
    1145                 1150                 1155             


Arg Ser  Val Ser Leu Arg Ala  Arg Ala Gly Ile Ala  Arg Ile His 
    1160                 1165                 1170             


Ala Pro  Arg Asp Leu Gln Thr  Met His Phe Leu Ala  Lys Val Ala 
    1175                 1180                 1185             


Ser Ser  Arg Lys Gln His Leu  Pro Leu Lys Asn Ala  Gly Asn Ile 
    1190                 1195                 1200             


Glu Val  Tyr Leu Asp Ile Lys  Val Pro Glu Gln Gly  Ser His Phe 
    1205                 1210                 1215             


Ser Val  Asp Pro Lys Asn Leu  Leu Leu Lys Pro Gly  Glu Glu His 
    1220                 1225                 1230             


Glu Val  Ile Val Ser Phe Thr  Pro Lys Asp Pro Glu  Ala Cys Glu 
    1235                 1240                 1245             


Glu Arg  Ile Leu Lys Ile Phe  Val Gln Pro Phe Gly  Pro Gln Tyr 
    1250                 1255                 1260             


Glu Val  Val Leu Lys Gly Glu  Val Ile Ser Ser Gly  Ser Lys Pro 
    1265                 1270                 1275             


Leu Ser  Pro Gly Pro Cys Leu  Asp Ile Pro Ser Ile  Leu Ser Asn 
    1280                 1285                 1290             


Lys Gln  Phe Leu Ala Trp Gly  Gly Val Pro Leu Gly  Arg Thr Gln 
    1295                 1300                 1305             


Leu Gln  Lys Leu Ala Leu Arg  Asn Asn Ser Ala Ser  Thr Thr Gln 
    1310                 1315                 1320             


His Leu  Arg Leu Leu Ile Arg  Gly Gln Asp Gln Asp  Cys Phe Gln 
    1325                 1330                 1335             


Leu Gln  Asn Thr Phe Gly Ser  Glu Gln Arg Leu Thr  Ser Asn Cys 
    1340                 1345                 1350             


Glu Ile  Arg Ile His Pro Lys  Glu Asp Ile Phe Ile  Ser Val Leu 
    1355                 1360                 1365             


Phe Ala  Pro Thr Arg Leu Ser  Cys Met Leu Ala Arg  Leu Glu Ile 
    1370                 1375                 1380             


Lys Gln  Leu Gly Asn Arg Ser  Gln Pro Gly Ile Lys  Phe Thr Ile 
    1385                 1390                 1395             


Pro Leu  Ser Gly Tyr Gly Gly  Thr Ser Asn Leu Ile  Leu Glu Gly 
    1400                 1405                 1410             


Val Lys  Lys Leu Ser Asp Ser  Tyr Met Val Thr Val  Asn Gly Leu 
    1415                 1420                 1425             


Val Pro  Gly Lys Glu Ser Lys  Ile Val Phe Ser Val  Arg Asn Thr 
    1430                 1435                 1440             


Gly Ser  Arg Ala Ala Phe Val  Lys Ala Val Gly Phe  Lys Asp Ser 
    1445                 1450                 1455             


Gln Lys  Lys Val Leu Leu Asp  Pro Lys Val Leu Arg  Ile Phe Pro 
    1460                 1465                 1470             


Asp Lys  Phe Val Leu Lys Glu  Arg Thr Gln Glu Asn  Val Thr Leu 
    1475                 1480                 1485             


Ile Tyr  Asn Pro Ser Asp Arg  Gly Ile Asn Asn Lys  Thr Ala Thr 
    1490                 1495                 1500             


Glu Leu  Ser Thr Val Tyr Leu  Phe Gly Gly Asp Glu  Ile Ser Arg 
    1505                 1510                 1515             


Gln Gln  Tyr Arg Arg Ala Leu  Leu His Lys Pro Glu  Met Ile Lys 
    1520                 1525                 1530             


Gln Ile  Leu Pro Glu His Ser  Val Leu Gln Asn Ile  Asn Phe Val 
    1535                 1540                 1545             


Glu Ala  Phe Gln Asp Glu Leu  Leu Val Thr Glu Val  Tyr Asp Leu 
    1550                 1555                 1560             


Pro Gln  Arg Pro Asn Asp Val  Gln Leu Phe Tyr Gly  Ser Met Cys 
    1565                 1570                 1575             


Lys Ile  Ile Leu Ser Val Ile  Gly Glu Phe Arg Asp  Cys Ile Ser 
    1580                 1585                 1590             


Ser Arg  Glu Phe Leu Gln Pro  Ser Ser Lys Ala Ser  Leu Glu Ser 
    1595                 1600                 1605             


Thr Ser  Asp Leu Gly Ala Ser  Gly Lys His Gly Gly  Asn Val Ser 
    1610                 1615                 1620             


Leu Asp  Val Leu Pro Val Lys  Gly Pro Gln Gly Ser  Pro Leu Leu 
    1625                 1630                 1635             


Ser Arg  Ala Ala Arg Pro Pro  Leu Asp Gln Leu Ala  Ser Glu Glu 
    1640                 1645                 1650             


Pro Trp  Thr Val Leu Pro Glu  His Leu Ile Leu Val  Ala Pro Ser 
    1655                 1660                 1665             


Pro Cys  Asp Met Ala Lys Thr  Gly Arg Phe Gln Ile  Val Asn Asn 
    1670                 1675                 1680             


Ser Val  Arg Leu Leu Arg Phe  Glu Leu Cys Trp Pro  Ala His Cys 
    1685                 1690                 1695             


Leu Thr  Val Thr Pro Gln His  Gly Cys Val Ala Pro  Glu Ser Lys 
    1700                 1705                 1710             


Leu Gln  Ile Leu Val Ser Pro  Asn Ser Ser Leu Ser  Thr Lys Gln 
    1715                 1720                 1725             


Ser Met  Phe Pro Trp Ser Gly  Leu Ile Tyr Ile His  Cys Asp Asp 
    1730                 1735                 1740             


Gly Gln  Lys Lys Ile Val Lys  Val Gln Ile Arg Glu  Asp Leu Thr 
    1745                 1750                 1755             


Gln Val  Glu Leu Leu Thr Arg  Leu Thr Ser Lys Pro  Phe Gly Ile 
    1760                 1765                 1770             


Leu Ser  Pro Val Ser Glu Pro  Ser Val Ser His Leu  Val Lys Pro 
    1775                 1780                 1785             


Met Thr  Lys Pro Pro Ser Thr  Lys Val Glu Ile Arg  Asn Lys Ser 
    1790                 1795                 1800             


Ile Thr  Phe Pro Thr Thr Glu  Pro Gly Glu Thr Ser  Glu Ser Cys 
    1805                 1810                 1815             


Leu Glu  Leu Glu Asn His Gly  Thr Thr Asp Val Lys  Trp His Leu 
    1820                 1825                 1830             


Ser Ser  Leu Ala Pro Pro Tyr  Val Lys Gly Val Asp  Glu Ser Gly 
    1835                 1840                 1845             


Asp Val  Phe Arg Ala Thr Tyr  Ala Ala Phe Arg Cys  Ser Pro Ile 
    1850                 1855                 1860             


Ser Gly  Leu Leu Glu Ser His  Gly Ile Gln Lys Val  Ser Ile Thr 
    1865                 1870                 1875             


Phe Leu  Pro Arg Gly Arg Gly  Asp Tyr Ala Gln Phe  Trp Asp Val 
    1880                 1885                 1890             


Glu Cys  His Pro Leu Lys Glu  Pro His Met Lys His  Thr Leu Arg 
    1895                 1900                 1905             


Phe Gln  Leu Ser Gly Gln Ser  Ile Glu Ala Glu Asn  Glu Pro Glu 
    1910                 1915                 1920             


Asn Ala  Cys Leu Ser Thr Asp  Ser Leu Ile Lys Ile  Asp His Leu 
    1925                 1930                 1935             


Val Lys  Pro Arg Arg Gln Ala  Val Ser Glu Ala Ser  Ala Arg Ile 
    1940                 1945                 1950             


Pro Glu  Gln Leu Asp Val Thr  Ala Arg Gly Val Tyr  Ala Pro Glu 
    1955                 1960                 1965             


Asp Val  Tyr Arg Phe Arg Pro  Thr Ser Val Gly Glu  Ser Arg Thr 
    1970                 1975                 1980             


Leu Lys  Val Asn Leu Arg Asn  Asn Ser Phe Ile Thr  His Ser Leu 
    1985                 1990                 1995             


Lys Phe  Leu Ser Pro Arg Glu  Pro Phe Tyr Val Lys  His Ser Lys 
    2000                 2005                 2010             


Tyr Ser  Leu Arg Ala Gln His  Tyr Ile Asn Met Pro  Val Gln Phe 
    2015                 2020                 2025             


Lys Pro  Lys Ser Ala Gly Lys  Phe Glu Ala Leu Leu  Val Ile Gln 
    2030                 2035                 2040             


Thr Asp  Glu Gly Lys Ser Ile  Ala Ile Arg Leu Ile  Gly Glu Ala 
    2045                 2050                 2055             


Leu Gly  Lys Asn 
    2060         


<210> 7611
<211> 514
<212> PRT
<213> Homo sapiens

<400> 7611
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln Thr Arg Gln 
                85                  90                  95      


Gln Ala Tyr Arg Asp Lys Leu Ala Gln Gln Gln Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ser Gln Gln Gly Ser Ala Lys Asn Gly Glu 
        115                 120                 125             


Asn Thr Ala Asn Gly Glu Glu Asn Gly Ala His Thr Ile Ala Asn Asn 
    130                 135                 140                 


His Thr Asp Met Met Glu Val Asp Gly Asp Val Glu Ile Pro Pro Asn 
145                 150                 155                 160 


Lys Ala Val Val Leu Arg Gly His Glu Ser Glu Val Phe Ile Cys Ala 
                165                 170                 175     


Trp Asn Pro Val Ser Asp Leu Leu Ala Ser Gly Ser Gly Asp Ser Thr 
            180                 185                 190         


Ala Arg Ile Trp Asn Leu Ser Glu Asn Ser Thr Ser Gly Ser Thr Gln 
        195                 200                 205             


Leu Val Leu Arg His Cys Ile Arg Glu Gly Gly Gln Asp Val Pro Ser 
    210                 215                 220                 


Asn Lys Asp Val Thr Ser Leu Asp Trp Asn Ser Glu Gly Thr Leu Leu 
225                 230                 235                 240 


Ala Thr Gly Ser Tyr Asp Gly Phe Ala Arg Ile Trp Thr Lys Asp Gly 
                245                 250                 255     


Asn Leu Ala Ser Thr Leu Gly Gln His Lys Gly Pro Ile Phe Ala Leu 
            260                 265                 270         


Lys Trp Asn Lys Lys Gly Asn Phe Ile Leu Ser Ala Gly Val Asp Lys 
        275                 280                 285             


Thr Thr Ile Ile Trp Asp Ala His Thr Gly Glu Ala Lys Gln Gln Phe 
    290                 295                 300                 


Pro Phe His Ser Ala Pro Ala Leu Asp Val Asp Trp Gln Ser Asn Asn 
305                 310                 315                 320 


Thr Phe Ala Ser Cys Ser Thr Asp Met Cys Ile His Val Cys Lys Leu 
                325                 330                 335     


Gly Gln Asp Arg Pro Ile Lys Thr Phe Gln Gly His Thr Asn Glu Val 
            340                 345                 350         


Asn Ala Ile Lys Trp Asp Pro Thr Gly Asn Leu Leu Ala Ser Cys Ser 
        355                 360                 365             


Asp Asp Met Thr Leu Lys Ile Trp Ser Met Lys Gln Asp Asn Cys Val 
    370                 375                 380                 


His Asp Leu Gln Ala His Asn Lys Glu Ile Tyr Thr Ile Lys Trp Ser 
385                 390                 395                 400 


Pro Thr Gly Pro Gly Thr Asn Asn Pro Asn Ala Asn Leu Met Leu Ala 
                405                 410                 415     


Ser Ala Ser Phe Asp Ser Thr Val Arg Leu Trp Asp Val Asp Arg Gly 
            420                 425                 430         


Ile Cys Ile His Thr Leu Thr Lys His Gln Glu Pro Val Tyr Ser Val 
        435                 440                 445             


Ala Phe Ser Pro Asp Gly Arg Tyr Leu Ala Ser Gly Ser Phe Asp Lys 
    450                 455                 460                 


Cys Val His Ile Trp Asn Thr Gln Thr Gly Ala Leu Val His Ser Tyr 
465                 470                 475                 480 


Arg Gly Thr Gly Gly Ile Phe Glu Val Cys Trp Asn Ala Ala Gly Asp 
                485                 490                 495     


Lys Val Gly Ala Ser Ala Ser Asp Gly Ser Val Cys Val Leu Asp Leu 
            500                 505                 510         


Arg Lys 
        


<210> 7612
<211> 677
<212> PRT
<213> Homo sapiens

<400> 7612
Met Glu Glu Thr Met Lys Leu Ala Thr Met Glu Asp Thr Val Glu Tyr 
1               5                   10                  15      


Cys Leu Phe Leu Ile Pro Asp Glu Ser Arg Asp Ser Asp Lys His Lys 
            20                  25                  30          


Glu Ile Leu Gln Lys Tyr Ile Glu Arg Ile Ile Thr Arg Phe Ala Pro 
        35                  40                  45              


Met Leu Val Pro Tyr Ile Trp Gln Asn Gln Pro Phe Asn Leu Lys Tyr 
    50                  55                  60                  


Lys Pro Gly Lys Gly Gly Val Pro Ala His Met Phe Gly Val Thr Lys 
65                  70                  75                  80  


Phe Gly Asp Asn Ile Glu Asp Glu Trp Phe Ile Val Tyr Val Ile Lys 
                85                  90                  95      


Gln Ile Thr Lys Glu Phe Pro Glu Leu Val Ala Arg Ile Glu Asp Asn 
            100                 105                 110         


Asp Gly Glu Phe Leu Leu Ile Glu Ala Ala Asp Phe Leu Pro Lys Trp 
        115                 120                 125             


Leu Asp Pro Glu Asn Ser Thr Asn Arg Val Phe Phe Cys His Gly Glu 
    130                 135                 140                 


Leu Cys Ile Ile Pro Ala Pro Arg Lys Ser Gly Ala Glu Ser Trp Leu 
145                 150                 155                 160 


Pro Thr Thr Pro Pro Thr Ile Pro Gln Ala Leu Asn Ile Ile Thr Ala 
                165                 170                 175     


His Ser Glu Lys Ile Leu Ala Ser Glu Ser Ile Arg Ala Ala Val Asn 
            180                 185                 190         


Arg Arg Ile Arg Gly Tyr Pro Glu Lys Ile Gln Ala Ser Leu His Arg 
        195                 200                 205             


Ala His Cys Phe Leu Pro Ala Gly Ile Val Ala Val Leu Lys Gln Arg 
    210                 215                 220                 


Pro Arg Leu Val Ala Ala Ala Val Gln Ala Phe Tyr Leu Arg Asp Pro 
225                 230                 235                 240 


Ile Asp Leu Arg Ala Cys Arg Val Phe Lys Thr Phe Leu Pro Glu Thr 
                245                 250                 255     


Arg Ile Met Thr Ser Val Thr Phe Thr Lys Cys Leu Tyr Ala Gln Leu 
            260                 265                 270         


Val Gln Gln Arg Phe Val Pro Asp Arg Arg Ser Gly Tyr Arg Leu Pro 
        275                 280                 285             


Pro Pro Ser Asp Pro Gln Tyr Arg Ala His Glu Leu Gly Met Lys Leu 
    290                 295                 300                 


Ala His Gly Phe Glu Ile Leu Cys Ser Lys Cys Ser Pro His Phe Ser 
305                 310                 315                 320 


Asp Cys Lys Lys Ser Leu Val Thr Ala Ser Pro Leu Trp Ala Ser Phe 
                325                 330                 335     


Leu Glu Ser Leu Lys Lys Asn Asp Tyr Phe Lys Gly Leu Ile Glu Gly 
            340                 345                 350         


Ser Ala Gln Tyr Arg Glu Arg Leu Glu Met Ala Glu Asn Tyr Phe Gln 
        355                 360                 365             


Leu Ser Val Asp Trp Pro Glu Arg Leu Glu Val Gln Trp Arg Asp Pro 
    370                 375                 380                 


Gly Leu Leu Gln Ala Pro Pro Pro Gly Phe Thr Pro Phe Ile Cys Leu 
385                 390                 395                 400 


Ser Leu Leu Ser Thr Trp Asp Asn Ser Ser Leu Ala Met Ser Pro Gly 
                405                 410                 415     


Glu Glu Ile Leu Thr Leu Leu Gln Thr Ile Pro Phe Asp Ile Glu Asp 
            420                 425                 430         


Leu Lys Lys Glu Ala Ala Asn Leu Pro Pro Glu Asp Asp Asp Gln Trp 
        435                 440                 445             


Leu Asp Leu Ser Pro Asp Gln Leu Asp Gln Leu Leu Gln Glu Ala Val 
    450                 455                 460                 


Gly Lys Lys Glu Ser Glu Ser Val Ser Lys Glu Glu Lys Glu Gln Asn 
465                 470                 475                 480 


Tyr Asp Leu Thr Glu Val Ser Glu Ser Met Lys Ala Phe Ile Ser Lys 
                485                 490                 495     


Val Ser Thr His Lys Gly Ala Glu Leu Pro Arg Glu Pro Ser Glu Ala 
            500                 505                 510         


Pro Ile Thr Phe Asp Ala Asp Ser Phe Leu Asn Tyr Phe Asp Lys Ile 
        515                 520                 525             


Leu Gly Pro Arg Pro Asn Glu Ser Asp Ser Asp Asp Leu Asp Asp Glu 
    530                 535                 540                 


Asp Phe Glu Cys Leu Asp Ser Asp Asp Asp Leu Asp Phe Glu Thr His 
545                 550                 555                 560 


Glu Pro Gly Glu Glu Ala Ser Leu Lys Gly Thr Leu Asp Asn Leu Lys 
                565                 570                 575     


Ser Tyr Met Ala Gln Met Asp Gln Glu Leu Ala His Thr Cys Ile Ser 
            580                 585                 590         


Lys Ser Phe Thr Thr Arg Asn Gln Val Glu Pro Val Ser Gln Thr Thr 
        595                 600                 605             


Asp Asn Asn Ser Asp Glu Glu Asp Ser Gly Thr Gly Glu Ser Val Met 
    610                 615                 620                 


Ala Pro Val Asp Val Asp Leu Asn Leu Val Ser Asn Ile Leu Glu Ser 
625                 630                 635                 640 


Tyr Ser Ser Gln Ala Gly Leu Ala Gly Pro Ala Ser Asn Leu Leu Gln 
                645                 650                 655     


Ser Met Gly Val Gln Leu Pro Asp Asn Thr Asp His Arg Pro Thr Ser 
            660                 665                 670         


Lys Pro Thr Lys Asn 
        675         


<210> 7613
<211> 606
<212> PRT
<213> Homo sapiens

<400> 7613
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Thr Tyr Ile Pro Asn Thr Lys Val Glu Cys 
            20                  25                  30          


His Tyr Thr Leu Pro Pro Gly Thr Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Thr Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Thr Thr Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Thr Ser Val Gln Phe Gln Glu Pro Arg Pro Met Asp Glu Leu Val Thr 
                85                  90                  95      


Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro Lys 
            100                 105                 110         


Ala Thr Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg Asn 
        115                 120                 125             


Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Thr Glu Leu 
    130                 135                 140                 


Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Thr Ala Arg Gln 
145                 150                 155                 160 


Glu His Thr Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser His 
                165                 170                 175     


Gly Glu Ile Thr Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly Asp 
            180                 185                 190         


His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Thr Ile Ser 
        195                 200                 205             


Glu Lys Val Leu Thr Lys Glu Val Glu Leu Asp Arg Leu Arg Asp Thr 
    210                 215                 220                 


Val Lys Ala Leu Thr Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu Lys 
225                 230                 235                 240 


Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Glu Pro Leu 
                245                 250                 255     


Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala Ala Ser Ser Gln Gln 
            260                 265                 270         


Lys Ala Thr Leu Leu Gly Glu Glu Leu Ala Ser Ala Ala Ala Ala Arg 
        275                 280                 285             


Asp Arg Thr Ile Ala Glu Leu His Arg Ser Arg Leu Glu Val Ala Glu 
    290                 295                 300                 


Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His Leu Lys Glu Glu Lys 
305                 310                 315                 320 


Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu Gln Ser Val Glu Ala 
                325                 330                 335     


Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu Ile Leu Arg Leu Glu 
            340                 345                 350         


Lys Ala Val Gln Glu Glu Arg Thr Gln Asn Gln Val Phe Lys Thr Glu 
        355                 360                 365             


Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln Leu Ser Glu Ser Lys 
    370                 375                 380                 


Arg Glu Leu Thr Glu Leu Arg Ser Ala Leu Arg Val Leu Gln Lys Glu 
385                 390                 395                 400 


Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu Leu Glu Tyr Met Arg 
                405                 410                 415     


Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp Glu Lys Trp Asn Glu 
            420                 425                 430         


Asp Ala Thr Thr Glu Asp Glu Glu Ala Ala Val Gly Leu Ser Cys Pro 
        435                 440                 445             


Ala Ala Leu Thr Asp Ser Glu Asp Glu Ser Pro Glu Asp Met Arg Leu 
    450                 455                 460                 


Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro Gly Ser Ser Pro Ala 
465                 470                 475                 480 


Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile Ser Gln Pro Ala Pro 
                485                 490                 495     


Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp Ser Ser Ser Asp Ser 
            500                 505                 510         


Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala Ala Val Gln Ser Gly 
        515                 520                 525             


Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu Gly Ser Ala Phe Tyr 
    530                 535                 540                 


Asp Met Ala Ser Gly Phe Thr Val Gly Thr Leu Ser Glu Thr Ser Thr 
545                 550                 555                 560 


Gly Gly Pro Ala Thr Pro Thr Trp Lys Glu Cys Pro Ile Cys Lys Glu 
                565                 570                 575     


Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala Leu Glu Asp His Met Asp 
            580                 585                 590         


Gly His Phe Phe Phe Ser Thr Gln Asp Pro Phe Thr Phe Glu 
        595                 600                 605     


<210> 7614
<211> 998
<212> PRT
<213> Homo sapiens

<400> 7614
Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe 
        115                 120                 125             


Gly Val Thr Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser 
    130                 135                 140                 


Asn Phe Leu Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu 
145                 150                 155                 160 


Val Ala Cys Gln Ile Val Leu Pro Asp Pro Gly Ile Ala Gly Phe Thr 
                165                 170                 175     


Val Ile Asp Tyr Phe His Gln Leu Leu Gln Thr Phe Asn Phe Arg Lys 
            180                 185                 190         


Leu Gln Cys Asp Ser Gln Ala Pro Asn Asn His Leu Leu Ala Leu Asp 
        195                 200                 205             


His Ser Asn Ser Asp Leu Ser Ser Ile Tyr Thr Ser Asp Ser Thr Ser 
    210                 215                 220                 


Asp Phe Phe Lys Ser Cys Ser Lys Asp Thr Phe Ser Lys Phe Trp Gln 
225                 230                 235                 240 


Pro Ser Leu Glu Phe Thr Cys Ile Val Ser Gln Leu Thr Asp Asn Asp 
                245                 250                 255     


Asp Phe Ser Ala Ser Glu Gln Ser Lys Ala Phe Gly Thr Leu Gln Gln 
            260                 265                 270         


Asn Arg Lys Ser Ile Ser Ile Ala Glu Ala Thr Gly Ser Ser Ser Cys 
        275                 280                 285             


His Asp Pro Ile Gln Asp Ser Trp Ser Leu Val Ser Tyr Met Asp Lys 
    290                 295                 300                 


Lys Ser Thr Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu Gln Ala Lys 
305                 310                 315                 320 


Glu Leu Ser Ala Val His Ser Ser His His Glu Ile Gly Val Asn Asp 
                325                 330                 335     


Ser Asn Leu Phe Ser Leu Glu Met Arg Glu Pro Leu Glu Ser Ser Asn 
            340                 345                 350         


Thr Lys Ser Phe His Ser Ala Val Glu Ile Lys Asn Arg Ser Gln His 
        355                 360                 365             


Glu Leu Pro Cys Phe Gln His His Gly Ile Asp Thr Pro Thr Ser Leu 
    370                 375                 380                 


Gln Lys Arg Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg Leu Glu Glu 
385                 390                 395                 400 


Thr Ala Ser Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp Asp Asp Leu 
                405                 410                 415     


Pro Phe Ser Glu Ser Leu Asn Lys Phe Leu Ala Val Leu Glu Ser Glu 
            420                 425                 430         


Ile Ala Val Thr Gln Ala Asp Val Ser Ser Arg Lys His His Val Asp 
        435                 440                 445             


Asn Asp Ile Asp Lys Phe His Ala Asp His Ser Arg Leu Ser Val Thr 
    450                 455                 460                 


Pro Gln Arg Thr Thr Gly Ala Leu His Thr Pro Pro Ile Ala Leu Arg 
465                 470                 475                 480 


Ser Ser Gln Val Ile Val Lys Ala Asn Cys Ser Lys Asp Asp Phe Leu 
                485                 490                 495     


Phe Asn Cys Lys Gly Asn Leu Ser Pro Ser Val Glu Lys Glu Ser Gln 
            500                 505                 510         


Pro Asp Asn Lys Val Glu Ala Val Ser Val Asn His Asn Gly Arg Asp 
        515                 520                 525             


Met Ser Glu Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala Leu Ser Ser 
    530                 535                 540                 


Ser Ser Lys Asp Leu Glu Thr Ile Val Thr Leu Lys Lys Thr Ile Arg 
545                 550                 555                 560 


Ile Ser Pro His Arg Glu Ser Asp His Ser Ser Leu Asn Asn Lys Tyr 
                565                 570                 575     


Leu Asn Gly Cys Gly Glu Ile Ser Val Ser Glu Met Asn Glu Lys Leu 
            580                 585                 590         


Thr Thr Leu Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp Leu Cys Lys 
        595                 600                 605             


Leu Glu Asn Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln Asp Asp Ser 
    610                 615                 620                 


Phe Thr Ile Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr Leu Cys Asn 
625                 630                 635                 640 


Ser Pro Asn Arg Ser Thr Asn Thr Leu Lys Glu Met Pro Trp Gly His 
                645                 650                 655     


Ile Asn Asn Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr Glu Gly Ser 
            660                 665                 670         


Tyr Asp Ala Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys Glu Met Asp 
        675                 680                 685             


Ile Ala Thr Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu Leu Lys Trp 
    690                 695                 700                 


Gly Thr Ser Leu Ala Glu Ser His Pro Ser Glu Ser Asp Phe Ser Leu 
705                 710                 715                 720 


Arg Ser Leu Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys Leu Ser Leu 
                725                 730                 735     


Gln Ser Leu Ser Asp Ser Arg His Ser Arg Thr Cys Ser Pro Thr Pro 
            740                 745                 750         


His Phe Gln Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser Gln Asp Phe 
        755                 760                 765             


Val Pro Cys Ser Gln Ser Thr Pro Ile Ser Gly Phe His Gln Thr Arg 
    770                 775                 780                 


Ile His Gly Ile Asn Arg Ala Phe Lys Lys Pro Val Phe Tyr Ser Asp 
785                 790                 795                 800 


Leu Asp Gly Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu Asn Asp Lys 
                805                 810                 815     


Gln Gln Ala Ser Pro Ser Cys Pro Lys Asn Ile Lys Thr Pro Ser Gln 
            820                 825                 830         


Lys Ile Arg Ser Pro Ile Val Ser Gly Val Ser Gln Pro Asp Val Phe 
        835                 840                 845             


Asn His Tyr Pro Phe Ala Glu Cys His Glu Thr Asp Ser Asp Glu Trp 
    850                 855                 860                 


Val Pro Pro Thr Thr Gln Lys Ile Phe Pro Ser Asp Met Leu Gly Phe 
865                 870                 875                 880 


Gln Gly Ile Gly Leu Gly Lys Cys Leu Ala Ala Tyr His Phe Pro Asp 
                885                 890                 895     


Gln Gln Glu Leu Pro Arg Lys Lys Leu Lys His Ile Arg Gln Gly Thr 
            900                 905                 910         


Asn Lys Gly Leu Ile Lys Lys Lys Leu Lys Asn Met Leu Ala Ala Val 
        915                 920                 925             


Val Thr Lys Lys Lys Thr His Lys Tyr Asn Cys Lys Ser Ser Gly Trp 
    930                 935                 940                 


Ile Ser Lys Cys Pro Asp Ile Gln Val Leu Ala Ala Pro Gln Leu His 
945                 950                 955                 960 


Pro Ile Leu Gly Pro Asp Ser Cys Ser Glu Val Lys Cys Cys Leu Pro 
                965                 970                 975     


Phe Ser Glu Lys Gly Pro Pro Ser Val Cys Glu Thr Arg Ser Ala Trp 
            980                 985                 990         


Ser Pro Glu Leu Phe Ser 
        995             


<210> 7615
<211> 156
<212> PRT
<213> Homo sapiens

<400> 7615
Met Ala Asp Ser Pro Gly Gly Tyr Lys Glu Cys Gly Thr Asn Glu Gly 
1               5                   10                  15      


Pro Gln Glu Asp Glu Asn Gly Ser Ser Ala Ser Gly Ser Ser Lys Val 
            20                  25                  30          


Arg Gln Leu Trp Ser Glu Asp Ser Cys Glu Ser Gly Lys Leu Pro Ala 
        35                  40                  45              


Thr Arg Thr Val Tyr Cys Met Asn Glu Ala Glu Ile Val Asp Val Ala 
    50                  55                  60                  


Leu Gly Ile Leu Ile Glu Ser Arg Lys Gln Glu Lys Ala Cys Glu Gln 
65                  70                  75                  80  


Pro Ala Leu Ala Gly Ala Asp Asn Pro Glu His Ser Pro Pro Cys Ser 
                85                  90                  95      


Val Ser Pro His Thr Ser Ser Gly Ser Ser Ser Glu Glu Glu Asp Ser 
            100                 105                 110         


Gly Lys Gln Ala Leu Ala Pro Gly Leu Ser Pro Ser Gln Arg Pro Gly 
        115                 120                 125             


Gly Ser Ser Ser Ala Cys Ser Arg Ser Pro Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Asp Val Leu Lys Tyr Val Arg Glu Ile Phe Phe Ser 
145                 150                 155     


<210> 7616
<211> 458
<212> PRT
<213> Homo sapiens

<400> 7616
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Thr Gln Asn Met 
145                 150                 155                 160 


Lys Met Gly Gly Leu Pro Arg Thr Thr Pro Pro Thr Gln Lys Pro Pro 
                165                 170                 175     


Ser Pro Pro Met Ser Gly Lys Gly Thr Leu Gly Ser Ser Gly Ser Ser 
            180                 185                 190         


Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser Gly 
        195                 200                 205             


Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Thr Pro Ser Pro Pro 
    210                 215                 220                 


Ser Val Phe Pro Ala Pro Ala Gly Ser Ala Gly Thr Pro Pro Leu Pro 
225                 230                 235                 240 


Ala Thr Ser Ala Ser Ala Pro Ala Pro Leu Val Pro Ala Thr Val Pro 
                245                 250                 255     


Ser Ser Thr Ala Pro Asp Ala Ala Ala Gly Gly Ala Gln Thr Leu Ala 
            260                 265                 270         


Asp Gly Phe Thr Ser Pro Thr Pro Pro Val Val Ser Ser Thr Pro Pro 
        275                 280                 285             


Thr Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser Arg 
    290                 295                 300                 


His Thr Pro Pro Thr Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro Pro 
305                 310                 315                 320 


Ser Ile Thr Ser Gln Thr Ser Leu Gln Asn Gln Met Asn Gly Gly Pro 
                325                 330                 335     


Phe Tyr Ser Gln Asn Pro Val Ser Asp Thr Pro Pro Pro Pro Pro Pro 
            340                 345                 350         


Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp Pro 
    370                 375                 380                 


Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu Lys 
385                 390                 395                 400 


Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp Lys Glu Asp Glu Leu Ser 
                405                 410                 415     


Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly 
            420                 425                 430         


Trp Tyr Glu Gly Val Met Asn Gly Val Thr Gly Leu Phe Pro Gly Asn 
        435                 440                 445             


Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
    450                 455             


<210> 7617
<211> 1740
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7617
Xaa Lys Ile Tyr Pro Glu Glu Ile Thr Pro Leu Leu Pro Ala Ile Ser 
1               5                   10                  15      


Gly Glu Lys Ile Ala Glu Asp Gln Thr Cys Phe Phe Leu Gln Ile Leu 
            20                  25                  30          


Leu Lys Tyr Met Val Ile Gln Ala Ala Ser Leu Glu Trp Lys Asn Lys 
        35                  40                  45              


Glu Asn Gln Asp Thr Gly Phe Lys Phe Leu Phe Thr Leu Phe Arg Lys 
    50                  55                  60                  


Tyr Tyr Leu Pro His Leu Phe Pro Ser Phe Thr Lys Leu Thr Asn Ile 
65                  70                  75                  80  


Tyr Lys Pro Val Leu Asp Ile Pro His Leu Arg Pro Lys Pro Val Tyr 
                85                  90                  95      


Ile Thr Thr Thr Arg Asp Asn Glu Asn Ile Tyr Ser Thr Lys Ile Pro 
            100                 105                 110         


Tyr Met Ala Ala Arg Val Val Phe Ile Lys Trp Ile Val Thr Phe Phe 
        115                 120                 125             


Leu Glu Lys Lys Tyr Leu Thr Ala Thr Gln Asn Thr Lys Asn Gly Val 
    130                 135                 140                 


Asp Val Leu Pro Lys Ile Ile Gln Thr Val Gly Gly Gly Ala Val Gln 
145                 150                 155                 160 


Glu Arg Ala Pro Glu Leu Asp Gly Gly Gly Pro Thr Glu Gln Asp Lys 
                165                 170                 175     


Ser His Ser Asn Ser Ser Thr Leu Ser Asp Arg Arg Leu Ser Asn Ser 
            180                 185                 190         


Ser Leu Cys Ser Ile Glu Glu Glu His Arg Met Val Tyr Glu Met Val 
        195                 200                 205             


Gln Arg Ile Leu Leu Ser Thr Arg Gly Tyr Val Asn Phe Val Asn Glu 
    210                 215                 220                 


Val Phe His Gln Ala Phe Leu Leu Pro Ser Cys Glu Ile Ala Val Thr 
225                 230                 235                 240 


Arg Lys Val Val Gln Val Tyr Arg Lys Trp Ile Leu Gln Asp Lys Pro 
                245                 250                 255     


Val Phe Met Glu Glu Pro Asp Arg Lys Asp Val Ala Gln Glu Asp Ala 
            260                 265                 270         


Glu Lys Leu Gly Phe Ser Glu Thr Asp Ser Lys Glu Ala Ser Ser Glu 
        275                 280                 285             


Ser Ser Gly His Lys Arg Ser Ser Ser Trp Gly Arg Thr Tyr Ser Phe 
    290                 295                 300                 


Thr Ser Ala Met Ser Arg Gly Cys Val Thr Glu Glu Glu Asn Thr Asn 
305                 310                 315                 320 


Val Lys Ala Gly Val Gln Ala Leu Leu Gln Val Phe Leu Thr Asn Ser 
                325                 330                 335     


Ala Asn Ile Phe Leu Leu Glu Pro Cys Ala Glu Val Pro Val Leu Leu 
            340                 345                 350         


Lys Glu Gln Val Asp Ala Cys Lys Ala Val Leu Ile Ile Phe Arg Arg 
        355                 360                 365             


Met Ile Met Glu Leu Thr Met Asn Lys Lys Thr Trp Glu Gln Met Leu 
    370                 375                 380                 


Gln Ile Leu Leu Arg Ile Thr Glu Ala Val Met Gln Lys Pro Lys Asp 
385                 390                 395                 400 


Lys Gln Ile Lys Asp Leu Phe Ala Gln Ser Leu Ala Gly Leu Leu Phe 
                405                 410                 415     


Arg Thr Leu Met Val Ala Trp Ile Arg Ala Asn Leu Cys Val Tyr Ile 
            420                 425                 430         


Ser Arg Glu Leu Trp Asp Asp Phe Leu Gly Val Leu Ser Ser Leu Thr 
        435                 440                 445             


Glu Trp Glu Glu Leu Ile Asn Glu Trp Ala Asn Ile Met Asp Ser Leu 
    450                 455                 460                 


Thr Ala Val Leu Ala Arg Thr Val Tyr Gly Val Glu Met Thr Asn Leu 
465                 470                 475                 480 


Pro Leu Asp Lys Leu Ser Glu Gln Lys Glu Lys Lys Gln Arg Gly Lys 
                485                 490                 495     


Gly Cys Val Leu Asp Pro Gln Lys Gly Thr Thr Val Gly Arg Ser Phe 
            500                 505                 510         


Ser Leu Ser Trp Arg Ser His Pro Asp Val Thr Glu Pro Met Arg Phe 
        515                 520                 525             


Arg Ser Ala Thr Thr Ser Gly Ala Pro Gly Val Glu Lys Ala Arg Asn 
    530                 535                 540                 


Ile Val Arg Gln Lys Ala Thr Glu Val Glu Glu Cys Gln Gln Ser Glu 
545                 550                 555                 560 


Asn Ala Pro Ala Ala Gly Ser Gly His Leu Thr Val Gly Gln Gln Gln 
                565                 570                 575     


Gln Val Leu Arg Ser Ser Ser Thr Ser Asp Ile Pro Glu Pro Leu Cys 
            580                 585                 590         


Ser Asp Ser Ser Gln Gly Gln Lys Ala Glu Asn Thr Gln Asn Ser Ser 
        595                 600                 605             


Ser Ser Glu Pro Gln Pro Ile Gln Glu Asn Lys Gly His Val Lys Arg 
    610                 615                 620                 


Glu His Glu Gly Ile Thr Ile Leu Val Arg Arg Ser Ser Ser Pro Ala 
625                 630                 635                 640 


Glu Leu Asp Leu Lys Asp Asp Leu Gln Gln Thr Gln Gly Lys Cys Arg 
                645                 650                 655     


Glu Arg Gln Lys Ser Glu Ser Thr Asn Ser Asp Thr Thr Leu Gly Cys 
            660                 665                 670         


Thr Asn Glu Ala Glu Leu Ser Met Gly Pro Trp Gln Thr Cys Glu Glu 
        675                 680                 685             


Asp Pro Glu Leu Asn Thr Pro Thr Asp Val Val Ala Asp Ala Asp Ala 
    690                 695                 700                 


Arg His Trp Leu Gln Leu Ser Pro Thr Asp Ala Ser Asn Leu Thr Asp 
705                 710                 715                 720 


Ser Ser Glu Cys Leu Thr Asp Asp Cys Ser Ile Ile Ala Gly Gly Ser 
                725                 730                 735     


Leu Thr Gly Trp His Pro Asp Ser Ala Ala Val Leu Trp Arg Arg Val 
            740                 745                 750         


Leu Gly Ile Leu Gly Asp Val Asn Asn Ile Gln Ser Pro Lys Ile His 
        755                 760                 765             


Ala Arg Val Phe Cys Tyr Leu Tyr Glu Leu Trp Tyr Lys Leu Ala Lys 
    770                 775                 780                 


Ile Arg Asp Asn Leu Ala Ile Ser Leu Asp Asn Gln Ser Ser Pro Ser 
785                 790                 795                 800 


Pro Pro Val Leu Ile Pro Pro Leu Arg Met Phe Ala Ser Trp Leu Phe 
                805                 810                 815     


Lys Ala Ala Thr Leu Pro Asn Glu Tyr Lys Glu Gly Lys Leu Gln Ala 
            820                 825                 830         


Tyr Arg Leu Ile Cys Ala Met Met Thr Arg Arg Gln Asp Val Leu Pro 
        835                 840                 845             


Asn Ser Asp Phe Leu Val His Phe Tyr Leu Val Met His Leu Gly Leu 
    850                 855                 860                 


Thr Ser Glu Asp Gln Asp Ile Leu Asn Thr Ile Ile Arg His Cys Pro 
865                 870                 875                 880 


Pro Arg Phe Phe Ser Leu Gly Phe Pro Gly Phe Ser Met Leu Val Gly 
                885                 890                 895     


Asp Phe Ile Thr Ala Ala Ala Arg Val Leu Ser Thr Asp Ile Leu Thr 
            900                 905                 910         


Ala Pro Arg Ser Glu Ala Val Thr Val Leu Gly Ser Leu Val Cys Phe 
        915                 920                 925             


Pro Asn Thr Tyr Gln Glu Ile Pro Leu Leu Gln Ser Val Pro Glu Val 
    930                 935                 940                 


Asn Glu Ala Ile Thr Gly Thr Glu Asp Val Lys His Tyr Leu Ile Asn 
945                 950                 955                 960 


Ile Leu Leu Lys Asn Ala Thr Glu Glu Pro Asn Glu Tyr Ala Arg Cys 
                965                 970                 975     


Ile Ala Val Cys Ser Leu Gly Val Trp Ile Cys Glu Glu Leu Ala Gln 
            980                 985                 990         


Cys Thr Ser His Pro Gln Val Lys  Glu Ala Ile Asn Val  Ile Gly Val 
        995                 1000                 1005             


Thr Leu  Lys Phe Pro Asn Lys  Ile Val Ala Gln Val  Ala Cys Asp 
    1010                 1015                 1020             


Val Leu  Gln Leu Leu Val Ser  Tyr Trp Glu Lys Leu  Gln Met Phe 
    1025                 1030                 1035             


Glu Thr  Ser Leu Pro Arg Lys  Met Ala Glu Ile Leu  Val Ala Thr 
    1040                 1045                 1050             


Val Ala  Phe Leu Leu Pro Ser  Ala Glu Tyr Ser Ser  Val Glu Thr 
    1055                 1060                 1065             


Asp Lys  Lys Phe Ile Val Ser  Leu Leu Leu Cys Leu  Leu Asp Trp 
    1070                 1075                 1080             


Cys Met  Ala Leu Pro Val Ser  Val Leu Leu His Pro  Val Ser Thr 
    1085                 1090                 1095             


Ala Val  Leu Glu Glu Gln His  Ser Ala Arg Ala Pro  Leu Leu Asp 
    1100                 1105                 1110             


Tyr Ile  Tyr Arg Val Leu His  Cys Cys Val Cys Gly  Ser Ser Thr 
    1115                 1120                 1125             


Tyr Thr  Gln Gln Ser His Tyr  Ile Leu Thr Leu Ala  Asp Leu Ser 
    1130                 1135                 1140             


Ser Thr  Asp Tyr Asp Pro Phe  Leu Pro Leu Ala Asn  Val Lys Ser 
    1145                 1150                 1155             


Ser Glu  Pro Val Gln Tyr His  Ser Ser Ala Glu Leu  Gly Asn Leu 
    1160                 1165                 1170             


Leu Thr  Val Glu Glu Glu Lys  Lys Arg Arg Ser Leu  Glu Leu Ile 
    1175                 1180                 1185             


Pro Leu  Thr Ala Arg Met Val  Met Ala His Leu Val  Asn His Leu 
    1190                 1195                 1200             


Gly His  Tyr Pro Leu Ser Gly  Gly Pro Ala Ile Leu  His Ser Leu 
    1205                 1210                 1215             


Val Ser  Glu Asn His Asp Asn  Ala His Val Glu Gly  Ser Glu Leu 
    1220                 1225                 1230             


Ser Phe  Glu Val Phe Arg Ser  Pro Asn Leu Gln Leu  Phe Val Phe 
    1235                 1240                 1245             


Asn Asp  Ser Thr Leu Ile Ser  Tyr Leu Gln Thr Pro  Thr Glu Gly 
    1250                 1255                 1260             


Pro Val  Gly Gly Ser Pro Val  Gly Ser Leu Ser Asp  Val Arg Val 
    1265                 1270                 1275             


Ile Val  Arg Asp Ile Ser Gly  Lys Tyr Ser Trp Asp  Gly Lys Val 
    1280                 1285                 1290             


Leu Tyr  Gly Pro Leu Glu Gly  Cys Leu Ala Pro Asn  Gly Arg Asn 
    1295                 1300                 1305             


Pro Ser  Phe Leu Ile Ser Ser  Trp His Arg Asp Thr  Phe Gly Pro 
    1310                 1315                 1320             


Gln Lys  Asp Ser Ser Gln Val  Glu Glu Gly Asp Asp  Val Leu Asp 
    1325                 1330                 1335             


Lys Leu  Leu Glu Asn Ile Gly  His Thr Ser Pro Glu  Cys Leu Leu 
    1340                 1345                 1350             


Pro Ser  Gln Leu Asn Leu Asn  Glu Pro Ser Leu Thr  Pro Cys Gly 
    1355                 1360                 1365             


Met Asn  Tyr Asp Gln Glu Lys  Glu Ile Ile Glu Val  Ile Leu Arg 
    1370                 1375                 1380             


Gln Asn  Ala Gln Glu Asp Glu  Tyr Ile Gln Ser His  Asn Phe Asp 
    1385                 1390                 1395             


Ser Ala  Met Lys Val Thr Ser  Gln Gly Gln Pro Ser  Pro Val Glu 
    1400                 1405                 1410             


Pro Arg  Gly Pro Phe Tyr Phe  Cys Arg Leu Leu Leu  Asp Asp Leu 
    1415                 1420                 1425             


Gly Met  Asn Ser Trp Asp Arg  Arg Lys Asn Phe His  Leu Leu Lys 
    1430                 1435                 1440             


Lys Asn  Ser Lys Leu Leu Arg  Glu Leu Lys Asn Leu  Asp Ser Arg 
    1445                 1450                 1455             


Gln Cys  Arg Glu Thr His Lys  Ile Ala Val Phe Tyr  Ile Ala Glu 
    1460                 1465                 1470             


Gly Gln  Glu Asp Lys Cys Ser  Ile Leu Ser Asn Glu  Arg Gly Ser 
    1475                 1480                 1485             


Gln Ala  Tyr Glu Asp Phe Val  Ala Gly Leu Gly Trp  Glu Val Asp 
    1490                 1495                 1500             


Leu Ser  Thr His Cys Gly Phe  Met Gly Gly Leu Gln  Arg Asn Gly 
    1505                 1510                 1515             


Ser Thr  Gly Gln Thr Ala Pro  Tyr Tyr Ala Thr Ser  Thr Val Glu 
    1520                 1525                 1530             


Val Ile  Phe His Val Ser Thr  Arg Met Pro Ser Asp  Ser Asp Asp 
    1535                 1540                 1545             


Ser Leu  Thr Lys Lys Leu Arg  His Leu Gly Asn Asp  Glu Val His 
    1550                 1555                 1560             


Ile Val  Trp Ser Glu His Ser  Arg Asp Tyr Arg Arg  Gly Ile Ile 
    1565                 1570                 1575             


Pro Thr  Ala Phe Gly Asp Val  Ser Ile Ile Ile Tyr  Pro Met Lys 
    1580                 1585                 1590             


Asn His  Met Phe Phe Ile Ala  Ile Thr Lys Lys Pro  Glu Val Pro 
    1595                 1600                 1605             


Phe Phe  Gly Pro Leu Phe Asp  Gly Ala Ile Val Ser  Gly Lys Leu 
    1610                 1615                 1620             


Leu Pro  Ser Leu Val Cys Ala  Thr Cys Ile Asn Ala  Ser Arg Ala 
    1625                 1630                 1635             


Val Lys  Cys Leu Ile Pro Leu  Tyr Gln Ser Phe Tyr  Glu Glu Arg 
    1640                 1645                 1650             


Ala Leu  Tyr Leu Glu Ala Ile  Ile Gln Asn His Arg  Glu Val Met 
    1655                 1660                 1665             


Thr Phe  Glu Asp Phe Ala Ala  Gln Val Phe Ser Pro  Ser Pro Ser 
    1670                 1675                 1680             


Tyr Ser  Leu Ser Gly Thr Gly  Ala Leu Ala Ser Ser  Leu Ser Ala 
    1685                 1690                 1695             


Asp Leu  Glu Glu Pro Leu Ser  Glu Glu Glu Thr Glu  His Pro Leu 
    1700                 1705                 1710             


Leu Pro  Leu Pro Arg Ala Thr  Lys Pro Arg Ile Ser  Arg Lys Phe 
    1715                 1720                 1725             


Arg Cys  Cys Thr Ser Ala Leu  Ser Arg Ser Ser His  
    1730                 1735                 1740 


<210> 7618
<211> 611
<212> PRT
<213> Homo sapiens

<400> 7618
Met Pro His Leu Asp Met Lys Thr His Val Cys Pro Ser Val Glu Gly 
1               5                   10                  15      


Pro Lys Lys Lys Gly Gly Ile Thr Cys Phe Cys Cys Gly Gly Pro Phe 
            20                  25                  30          


Arg Ala Ala Asp Arg Ser Lys Thr Arg Ser Pro Lys Leu Ser His Ser 
        35                  40                  45              


Pro Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr 
    50                  55                  60                  


Ser Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro 
65                  70                  75                  80  


Phe Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser 
                85                  90                  95      


Thr Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr 
            100                 105                 110         


Gly Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala 
        115                 120                 125             


Asp Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr 
    130                 135                 140                 


Met Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu 
145                 150                 155                 160 


Ser Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp 
                165                 170                 175     


Arg Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn 
            180                 185                 190         


His Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu 
        195                 200                 205             


Val Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr 
    210                 215                 220                 


Ala His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val 
225                 230                 235                 240 


Pro His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr 
                245                 250                 255     


Arg Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile 
            260                 265                 270         


Ser Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile 
        275                 280                 285             


Leu Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn 
    290                 295                 300                 


Ile Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr 
305                 310                 315                 320 


His Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu 
                325                 330                 335     


Asp Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser 
            340                 345                 350         


Ala Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu 
        355                 360                 365             


Gln Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu 
    370                 375                 380                 


Pro Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser 
385                 390                 395                 400 


Asp Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro 
                405                 410                 415     


Pro His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe 
            420                 425                 430         


Lys Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala 
        435                 440                 445             


Ala Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys 
    450                 455                 460                 


Gln Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr 
465                 470                 475                 480 


Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr Asp Ser 
                485                 490                 495     


Ala Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala Leu Glu 
            500                 505                 510         


Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser Ala Ile 
        515                 520                 525             


His Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu Arg Leu 
    530                 535                 540                 


Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu Leu Leu 
545                 550                 555                 560 


Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys Val Met 
                565                 570                 575     


Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg Val Leu 
            580                 585                 590         


Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys Ile Val 
        595                 600                 605             


Lys Lys Leu 
    610     


<210> 7619
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7619
Xaa Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser Val Ala 
1               5                   10                  15      


Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly Pro Trp 
            20                  25                  30          


Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val Val Gly 
        35                  40                  45              


Pro Met Trp Phe Val Pro Cys Ile Phe Gln Arg Tyr Asn Leu 
    50                  55                  60          


<210> 7620
<211> 622
<212> PRT
<213> Homo sapiens

<400> 7620
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 
            100                 105                 110         


Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 
        115                 120                 125             


Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 
    130                 135                 140                 


Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 
145                 150                 155                 160 


Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 
                165                 170                 175     


Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 
            180                 185                 190         


Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 
        195                 200                 205             


Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 
    210                 215                 220                 


Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 
225                 230                 235                 240 


His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 
                245                 250                 255     


Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 
            260                 265                 270         


Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 
        275                 280                 285             


Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 
    290                 295                 300                 


Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 
305                 310                 315                 320 


Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 
                325                 330                 335     


Gly Met Thr Ser Val Leu Met Ser Ala Ile Gly Leu Pro Val Cys Leu 
            340                 345                 350         


Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro Ala Ser Arg Leu Ala Ser 
        355                 360                 365             


Lys Ser His Gly Ser Val Lys Arg Leu Arg Lys Met Ser Val Lys Gly 
    370                 375                 380                 


Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn Tyr 
385                 390                 395                 400 


Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys Met 
                405                 410                 415     


Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser Lys 
            420                 425                 430         


Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His Ala 
        435                 440                 445             


Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys Asp 
    450                 455                 460                 


Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys Thr 
465                 470                 475                 480 


Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met Ser 
                485                 490                 495     


Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser Ile 
            500                 505                 510         


Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro Phe 
        515                 520                 525             


Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala Gln 
    530                 535                 540                 


Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg Leu 
545                 550                 555                 560 


Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr Val 
                565                 570                 575     


Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile Thr 
            580                 585                 590         


Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala Glu 
        595                 600                 605             


Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 
    610                 615                 620         


<210> 7621
<211> 181
<212> PRT
<213> Homo sapiens

<400> 7621
Met Gly Gly Arg Ser Ala Gln Ala Gly Leu Gly Thr Arg Ile Thr Pro 
1               5                   10                  15      


Met Met Glu Leu Lys Pro Asn Ala Gly Ser Asp Arg Ala Trp Val Trp 
            20                  25                  30          


Asn Thr His Ala Asp Phe Ala Asp Glu Cys Pro Lys Pro Glu Leu Leu 
        35                  40                  45              


Ala Ile Arg Phe Leu Asn Ala Glu Asn Ala Gln Lys Phe Lys Thr Lys 
    50                  55                  60                  


Phe Glu Glu Cys Arg Lys Glu Ile Glu Glu Arg Glu Lys Lys Gly Asp 
65                  70                  75                  80  


Val Val Pro Trp Val Gly Gly Leu Leu Cys Arg Leu Thr Leu His Leu 
                85                  90                  95      


Thr Ile Leu Pro Gly Gly Cys Phe Phe Cys Leu Pro Asp Lys His Ser 
            100                 105                 110         


Arg Val Leu Trp Pro Pro His Val Ser Arg Val Met Gln Leu Pro Gly 
        115                 120                 125             


Asp Thr Gly Ala Ser Trp Gly Ala Leu Ser Thr Cys Gln Cys Cys Trp 
    130                 135                 140                 


Pro Gln Ser Asn Trp Ala Gly Ile Gly Val Arg Ala Leu Pro Gly Ala 
145                 150                 155                 160 


His Gln Lys Val Leu Tyr Asp Gly Pro Arg Phe Val Ser Gln Arg Ala 
                165                 170                 175     


Trp Ser Pro Leu Pro 
            180     


<210> 7622
<211> 125
<212> PRT
<213> Homo sapiens

<400> 7622
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 
        35                  40                  45              


Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 
65                  70                  75                  80  


Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 
                85                  90                  95      


Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 
            100                 105                 110         


Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala 
        115                 120                 125 


<210> 7623
<211> 105
<212> PRT
<213> Homo sapiens

<400> 7623
Met Leu Arg Cys Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg 
1               5                   10                  15      


His Leu Gly Arg Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp 
            20                  25                  30          


Ser Tyr Phe Ser Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr 
        35                  40                  45              


Tyr Ser Ile His Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser 
    50                  55                  60                  


Ile Gly Gln Trp Tyr Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys 
65                  70                  75                  80  


Leu Ala Val Phe Asp Thr Trp Ser Ser Leu Ala Val His Ile Ala Met 
                85                  90                  95      


Asp Asn Thr Val Val Met Glu Glu Ile 
            100                 105 


<210> 7624
<211> 434
<212> PRT
<213> Homo sapiens

<400> 7624
Met Asp Ile Asp Lys Asp Leu Glu Ala Pro Leu Tyr Leu Thr Pro Glu 
1               5                   10                  15      


Gly Trp Ser Leu Phe Leu Gln Arg Tyr Tyr Gln Val Val His Glu Gly 
            20                  25                  30          


Ala Glu Leu Arg His Leu Asp Thr Gln Val Gln Arg Cys Glu Asp Ile 
        35                  40                  45              


Leu Gln Gln Leu Gln Ala Val Val Pro Gln Ile Asp Met Glu Gly Asp 
    50                  55                  60                  


Arg Asn Ile Trp Ile Val Lys Pro Gly Ala Lys Ser Arg Gly Arg Gly 
65                  70                  75                  80  


Ile Met Cys Met Asp His Leu Glu Glu Met Leu Lys Leu Val Asn Gly 
                85                  90                  95      


Asn Pro Val Val Met Lys Asp Gly Lys Trp Val Val Gln Lys Tyr Ile 
            100                 105                 110         


Glu Arg Pro Leu Leu Ile Phe Gly Thr Lys Phe Asp Leu Arg Gln Trp 
        115                 120                 125             


Phe Leu Val Thr Asp Trp Asn Pro Leu Thr Val Trp Phe Tyr Arg Asp 
    130                 135                 140                 


Ser Tyr Ile Arg Phe Ser Thr Gln Pro Phe Ser Leu Lys Asn Leu Asp 
145                 150                 155                 160 


Asn Ser Val His Leu Cys Asn Asn Ser Ile Gln Lys His Leu Glu Asn 
                165                 170                 175     


Ser Cys His Arg His Pro Leu Leu Pro Pro Asp Asn Met Trp Ser Ser 
            180                 185                 190         


Gln Arg Phe Gln Ala His Leu Gln Glu Met Gly Ala Pro Asn Ala Trp 
        195                 200                 205             


Ser Thr Ile Ile Val Pro Gly Met Lys Asp Ala Val Ile His Ala Leu 
    210                 215                 220                 


Gln Thr Ser Gln Asp Thr Val Gln Cys Arg Lys Ala Ser Phe Glu Leu 
225                 230                 235                 240 


Tyr Gly Ala Asp Phe Val Phe Gly Glu Asp Phe Gln Pro Trp Leu Ile 
                245                 250                 255     


Glu Ile Asn Ala Ser Pro Thr Met Ala Pro Ser Thr Ala Val Thr Ala 
            260                 265                 270         


Arg Leu Cys Ala Gly Val Gln Ala Asp Thr Leu Arg Val Val Ile Asp 
        275                 280                 285             


Arg Met Leu Asp Arg Asn Cys Asp Thr Gly Ala Phe Glu Leu Ile Tyr 
    290                 295                 300                 


Lys Gln Pro Ala Val Glu Val Pro Gln Tyr Val Gly Ile Arg Leu Leu 
305                 310                 315                 320 


Val Glu Gly Phe Thr Ile Lys Lys Pro Met Ala Met Cys His Arg Arg 
                325                 330                 335     


Met Gly Val Arg Pro Ala Val Pro Leu Leu Thr Gln Arg Gly Ser Gly 
            340                 345                 350         


Glu Ala Arg His His Phe Pro Ser Leu His Thr Lys Ala Gln Leu Pro 
        355                 360                 365             


Ser Pro His Val Leu Arg His Gln Gly Gln Val Leu Arg Arg Gln His 
    370                 375                 380                 


Ser Lys Leu Val Gly Thr Lys Ala Leu Ser Thr Thr Gly Lys Ala Leu 
385                 390                 395                 400 


Arg Thr Leu Pro Thr Ala Lys Val Phe Ile Ser Leu Pro Pro Asn Leu 
                405                 410                 415     


Asp Phe Lys Val Ala Pro Ser Ile Leu Lys Pro Arg Lys Val Gly Leu 
            420                 425                 430         


Asp Leu 
        


<210> 7625
<211> 191
<212> PRT
<213> Homo sapiens

<400> 7625
Met Ala Ile Gly Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys 
1               5                   10                  15      


Thr Gln Arg Leu Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro 
            20                  25                  30          


Ala Arg Val Trp Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg 
        35                  40                  45              


Val Pro His Thr Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro 
    50                  55                  60                  


Tyr Leu Ile Tyr Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr 
65                  70                  75                  80  


Ser Val Pro Ala Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser 
                85                  90                  95      


Val Glu Asn Leu Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly 
            100                 105                 110         


Ser Phe Ser Thr Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser 
        115                 120                 125             


Val Asp Asp Ile Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr 
    130                 135                 140                 


Asn Ser Cys Asp Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser 
145                 150                 155                 160 


Gln Glu Ser Lys Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg 
                165                 170                 175     


Arg Leu Ser Glu Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg 
            180                 185                 190     


<210> 7626
<211> 300
<212> PRT
<213> Homo sapiens

<400> 7626
Met Ala Lys Trp Gly Gln Gly Asn Pro His Trp Ile Val Glu Glu Arg 
1               5                   10                  15      


Glu Asp Gly Thr Asn Val Asn Asn Trp Arg Trp Arg Thr Glu Arg Asp 
            20                  25                  30          


Ala Thr Ser Leu Ser Lys Gly Lys Phe Gln Glu Leu Leu Val Gly Ile 
        35                  40                  45              


Val Val Glu Asn Asp Ala Gly Arg Gly Glu Ile Asn Glu Leu Lys Gln 
    50                  55                  60                  


Val Glu Gly Glu Ala Ser Cys Ser Ser Arg Lys Gly Lys Leu Ile Phe 
65                  70                  75                  80  


Phe Tyr Glu Trp Asn Ile Lys Leu Gly Trp Lys Gly Ile Val Lys Glu 
                85                  90                  95      


Ser Gly Val Lys His Lys Gly Leu Ile Glu Ile Pro Asn Leu Ser Glu 
            100                 105                 110         


Glu Asn Glu Val Asp Asp Thr Glu Val Ser Leu Ser Lys Lys Lys Gly 
        115                 120                 125             


Asp Gly Val Ile Leu Lys Asp Leu Met Lys Thr Ala Gly Thr Ala Lys 
    130                 135                 140                 


Val Arg Glu Ala Leu Gly Asp Tyr Leu Lys Ala Leu Lys Thr Glu Phe 
145                 150                 155                 160 


Thr Thr Gly Met Ile Leu Pro Thr Lys Ala Met Ala Thr Gln Glu Leu 
                165                 170                 175     


Thr Val Lys Arg Lys Leu Ser Gly Asn Thr Leu Gln Val Gln Ala Ser 
            180                 185                 190         


Ser Pro Val Ala Leu Gly Val Arg Ile Pro Thr Val Ala Leu His Met 
        195                 200                 205             


Met Glu Leu Phe Asp Thr Thr Val Glu Gln Leu Tyr Ser Ile Phe Thr 
    210                 215                 220                 


Val Lys Glu Leu Thr Asn Lys Lys Ile Ile Met Lys Trp Arg Cys Gly 
225                 230                 235                 240 


Asn Trp Pro Glu Glu His Tyr Ala Met Val Ala Leu Asn Phe Val Pro 
                245                 250                 255     


Thr Leu Gly Gln Thr Glu Leu Gln Leu Lys Glu Phe Leu Ser Ile Cys 
            260                 265                 270         


Lys Glu Glu Asn Met Lys Phe Cys Trp Gln Lys Gln His Phe Glu Glu 
        275                 280                 285             


Ile Lys Gly Ser Leu Gln Leu Thr Pro Leu Asn Gly 
    290                 295                 300 


<210> 7627
<211> 378
<212> PRT
<213> Homo sapiens

<400> 7627
Met Lys Asp Val Pro Gly Phe Leu Gln Gln Ser Gln Asn Ser Gly Pro 
1               5                   10                  15      


Gly Gln Pro Ala Val Trp His Arg Leu Glu Glu Leu Tyr Thr Lys Asn 
            20                  25                  30          


Phe Met Lys Thr Leu Ser Val Asn Leu Asn Thr Gly Lys Ser Leu Ser 
        35                  40                  45              


Ser Val Phe His Phe Glu Asn Glu Cys Ile Asp Ala Arg Arg Cys Ser 
    50                  55                  60                  


Lys Ala Gly Gly Phe Tyr Phe Arg Val Asn Pro Leu Ser Leu Val Glu 
65                  70                  75                  80  


Ile Ile Leu His Val Val Arg Gln Met Thr Asp Pro Asn Val Ala Leu 
                85                  90                  95      


Thr Phe Leu Glu Lys Thr Arg Glu Lys Val Lys Ser Ser Asp Glu Ala 
            100                 105                 110         


Val Ile Leu Cys Lys Thr Ala Ile Gly Ala Leu Lys Leu Asn Ile Gly 
        115                 120                 125             


Asp Leu Gln Val Thr Lys Glu Thr Ile Glu Asp Val Glu Glu Met Leu 
    130                 135                 140                 


Asn Asn Leu Pro Gly Val Thr Ser Val His Ser Arg Phe Tyr Asp Leu 
145                 150                 155                 160 


Ser Ser Lys Tyr Tyr Gln Thr Ile Gly Asn His Ala Ser Tyr Tyr Lys 
                165                 170                 175     


Asp Ala Leu Arg Phe Leu Gly Cys Val Asp Ile Lys Asp Leu Pro Val 
            180                 185                 190         


Ser Glu Gln Gln Glu Arg Ala Phe Thr Leu Gly Leu Ala Gly Leu Leu 
        195                 200                 205             


Gly Glu Gly Val Phe Asn Phe Gly Glu Leu Leu Met His Pro Val Leu 
    210                 215                 220                 


Glu Ser Leu Arg Asn Thr Asp Arg Gln Trp Leu Ile Asp Thr Leu Tyr 
225                 230                 235                 240 


Ala Phe Asn Ser Gly Asn Val Glu Arg Phe Gln Thr Leu Lys Thr Ala 
                245                 250                 255     


Trp Gly Gln Gln Pro Asp Leu Ala Ala Asn Glu Ala Gln Leu Leu Arg 
            260                 265                 270         


Lys Ile Gln Leu Leu Cys Leu Met Glu Met Thr Phe Thr Arg Pro Ala 
        275                 280                 285             


Asn His Arg Gln Leu Thr Phe Glu Glu Ile Ala Lys Ser Ala Lys Ile 
    290                 295                 300                 


Thr Val Asn Glu Val Glu Leu Leu Val Met Lys Ala Leu Ser Val Gly 
305                 310                 315                 320 


Leu Val Lys Gly Ser Ile Asp Glu Val Asp Lys Arg Val His Met Thr 
                325                 330                 335     


Trp Val Gln Pro Arg Val Leu Asp Leu Gln Gln Ile Lys Gly Met Lys 
            340                 345                 350         


Asp Arg Leu Glu Phe Trp Cys Thr Asp Val Lys Ser Met Glu Met Leu 
        355                 360                 365             


Val Glu His Gln Ala His Asp Ile Leu Thr 
    370                 375             


<210> 7628
<211> 200
<212> PRT
<213> Homo sapiens

<400> 7628
Met Leu Leu Glu Gln Asn Leu Ile Thr Val Asp Met Gln Lys His Ser 
1               5                   10                  15      


Leu Thr Phe Trp Trp Leu Val Glu Cys Trp Pro Gln Val Phe Asn Lys 
            20                  25                  30          


Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe Glu Asp Glu Val 
        35                  40                  45              


Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu Ser Glu Arg Asn 
    50                  55                  60                  


Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn Gly Thr Leu Asn 
65                  70                  75                  80  


Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu Val Lys Glu Gly 
                85                  90                  95      


Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser Trp Ile Asn Glu 
            100                 105                 110         


Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys Val Ser Met Asp 
        115                 120                 125             


Asn Arg Leu Met Glu Leu Phe Pro Ala Asn Lys Gln Ser Val Glu His 
    130                 135                 140                 


Phe Thr Lys Tyr Phe Thr Glu Ala Gly Leu Lys Glu Leu Ser Glu Tyr 
145                 150                 155                 160 


Val Arg Asn Gln Gln Thr Ile Gly Ala Arg Lys Glu Leu Gln Lys Glu 
                165                 170                 175     


Leu Gln Glu Gln Met Ser Arg Gly Asp Pro Phe Lys Asp Ile Ile Leu 
            180                 185                 190         


Tyr Val Lys Glu Glu Met Lys Lys 
        195                 200 


<210> 7629
<211> 481
<212> PRT
<213> Homo sapiens

<400> 7629
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 7630
<211> 86
<212> PRT
<213> Homo sapiens

<400> 7630
Met Gly Lys Met Val Ser Val Ile Asn Thr Val Asp Thr Ser His Glu 
1               5                   10                  15      


Asp Met Ile His Asp Ala Gln Met Asp Tyr Tyr Gly Thr Arg Leu Ala 
            20                  25                  30          


Thr Cys Ser Ser Asp Arg Ser Val Lys Ile Phe Asp Val Arg Asn Gly 
        35                  40                  45              


Gly Gln Ile Leu Ile Ala Asp Leu Arg Gly His Glu Gly Pro Val Trp 
    50                  55                  60                  


Gln Val Ala Trp Ala His Pro Met Tyr Gly Asn Ile Leu Ala Ser Cys 
65                  70                  75                  80  


Ser Tyr Asp Arg Lys Val 
                85      


<210> 7631
<211> 219
<212> PRT
<213> Homo sapiens

<400> 7631
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Thr Thr Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Thr Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro Pro Ser Phe Asn Leu His 
            100                 105                 110         


Pro Ala Pro His Leu Leu Ala Ser Met His Leu Gln Lys Leu Asn Ser 
        115                 120                 125             


Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro Gly Gln Pro Gly Glu Ala 
    130                 135                 140                 


Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala Gln Ala Gly Gly Ala Glu 
145                 150                 155                 160 


Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser Pro Ala Ile Ile Asp Ser 
                165                 170                 175     


Asp Pro Val Asp Glu Glu Val Leu Met Ser Leu Val Val Glu Leu Gly 
            180                 185                 190         


Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu 
        195                 200                 205             


Phe Asp Phe Thr Ala Asp Phe Pro Ser Ser Cys 
    210                 215                 


<210> 7632
<211> 131
<212> PRT
<213> Homo sapiens

<400> 7632
Met Leu Cys Trp Gly Tyr Trp Ser Leu Gly Gln Pro Gly Ile Ser Thr 
1               5                   10                  15      


Asn Leu Gln Gly Ile Val Ala Glu Pro Gln Val Cys Gly Phe Ile Ser 
            20                  25                  30          


Asp Arg Ser Val Lys Glu Val Ala Cys Gly Gly Asn His Ser Val Phe 
        35                  40                  45              


Leu Leu Glu Asp Gly Glu Val Tyr Thr Cys Gly Leu Asn Thr Lys Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Arg Glu Gly Asn Lys Pro Glu Gln Ile Gly Ala 
65                  70                  75                  80  


Leu Ala Asp Gln His Ile Ile His Val Ala Cys Gly Glu Ser His Ser 
                85                  90                  95      


Leu Ala Leu Ser Asp Arg Gly Gln Leu Phe Ser Trp Gly Ala Gly Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Met Thr Thr Glu Asp Ser Val Ala Val Pro 
        115                 120                 125             


Arg Leu Ile 
    130     


<210> 7633
<211> 1032
<212> PRT
<213> Homo sapiens

<400> 7633
Met Glu Gly Ala Leu Thr Ala Arg Asp Lys Val Gly Val Gln Asp Phe 
1               5                   10                  15      


Val Leu Leu Asp Ala Tyr Thr Ser Glu Ser Ala Phe Val Asp Asn Leu 
            20                  25                  30          


Arg Lys Arg Phe Ser Glu Asn Leu Ile Tyr Thr Tyr Ile Gly Thr Leu 
        35                  40                  45              


Leu Val Ser Val Asn Pro Tyr Gln Glu Leu Gly Ile Tyr Thr Val Ser 
    50                  55                  60                  


Gln Met Glu Leu Tyr Gln Gly Val Asn Phe Phe Glu Leu Pro Pro His 
65                  70                  75                  80  


Val Tyr Ala Ile Ala Asp Asn Ala Tyr Arg Met Met Cys Ala Glu Leu 
                85                  90                  95      


Asn Asn His Phe Ile Leu Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr 
            100                 105                 110         


Glu Ala Ser Lys Lys Ile Leu Glu Tyr Phe Ala Val Thr Cys Pro Met 
        115                 120                 125             


Thr Gln Ser Leu Gln Ile Ala Arg Asp Arg Leu Leu Phe Ser Asn Pro 
    130                 135                 140                 


Val Leu Glu Ala Phe Gly Asn Ala Arg Thr Leu Arg Asn Asp Asn Ser 
145                 150                 155                 160 


Ser Arg Phe Gly Lys Tyr Met Asp Ile Gln Phe Asp Phe Gln Gly Ile 
                165                 170                 175     


Pro Val Gly Gly His Ile Ile Ser Tyr Leu Ile Glu Lys Ser Arg Val 
            180                 185                 190         


Val Tyr Gln Asn Glu Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu 
        195                 200                 205             


Leu Ala Gly Gly Glu Glu Glu Arg Leu Ser Tyr Leu Gly Leu Glu Arg 
    210                 215                 220                 


Asp Pro Gln Leu Tyr Lys Tyr Leu Ser Gln Gly His Cys Ala Lys Glu 
225                 230                 235                 240 


Ser Ser Ile Ser Asp Lys Asn Asp Trp Lys Thr Val Ser Asn Ala Phe 
                245                 250                 255     


Ser Val Ile Asp Phe Thr Glu Ala Asp Leu Glu Asn Leu Phe Gly Ile 
            260                 265                 270         


Ile Ala Ser Val Leu His Leu Gly Asn Ile Gly Phe Glu Glu Asp Asp 
        275                 280                 285             


Gln Gly Cys Ala Thr Ile Pro Asp Thr His Glu Ile Lys Trp Ile Ala 
    290                 295                 300                 


Lys Leu Leu Gly Val His Pro Ser Val Leu Leu Glu Ala Leu Thr His 
305                 310                 315                 320 


Arg Lys Ile Glu Ala Lys Thr Glu Glu Val Ile Cys Pro Leu Thr Leu 
                325                 330                 335     


Glu Leu Ser Val Tyr Ala Arg Asp Ala Met Ala Lys Ala Val Tyr Gly 
            340                 345                 350         


Arg Thr Phe Thr Trp Leu Val Asn Lys Ile Asn Ser Ser Leu Val Asn 
        355                 360                 365             


Lys Val Gly Gln Arg Ile Leu Asp Pro Leu Leu Leu Leu Thr Trp Lys 
    370                 375                 380                 


Thr Val Ile Gly Leu Leu Asp Ile Tyr Gly Phe Glu Val Phe Asp Lys 
385                 390                 395                 400 


Asn Gly Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu Gln 
                405                 410                 415     


Gln Leu Leu Ile Glu Arg Thr Leu Lys Ala Glu Gln Ala Glu Tyr Glu 
            420                 425                 430         


Met Glu Gly Ile Glu Trp Glu Pro Ile Lys Tyr Phe Asn Asn Lys Ile 
        435                 440                 445             


Ile Cys Asp Leu Val Glu Glu Arg His Lys Gly Ile Ile Ser Ile Leu 
    450                 455                 460                 


Asp Glu Glu Cys Ile Arg Pro Gly Pro Ala Thr Asp Leu Ser Phe Leu 
465                 470                 475                 480 


Glu Lys Leu Glu Glu Lys Val Gly Lys His Ala His Phe Glu Thr Arg 
                485                 490                 495     


Lys Leu Ala Gly Pro Lys Gly Arg Lys Arg Ile Gly Trp Met Glu Phe 
            500                 505                 510         


Arg Leu Leu His Tyr Ala Gly Glu Val Thr Tyr Cys Thr Lys Gly Phe 
        515                 520                 525             


Leu Glu Lys Asn Asn Asp Leu Leu Tyr Arg His Leu Lys Glu Val Leu 
    530                 535                 540                 


Cys Lys Ser Lys Asn Ile Ile Leu Arg Glu Cys Phe Leu Leu Ala Glu 
545                 550                 555                 560 


Leu Glu Asn Arg Arg Arg Pro Pro Thr Val Gly Thr Gln Phe Lys Asn 
                565                 570                 575     


Ser Leu Ser Ser Leu Leu Glu Thr Leu Ile Ser Lys Glu Pro Ser Tyr 
            580                 585                 590         


Ile Arg Cys Ile Lys Pro Asn Asp Arg Lys Glu Pro Ser Lys Phe Asp 
        595                 600                 605             


Asp Phe Leu Ile Arg His Gln Ile Lys Tyr Leu Gly Leu Met Glu His 
    610                 615                 620                 


Leu Arg Val Arg Arg Ala Gly Phe Ala Tyr Arg Arg Lys Tyr Glu His 
625                 630                 635                 640 


Phe Leu Gln Arg Tyr Lys Ser Leu Cys Pro Asp Thr Trp Pro His Trp 
                645                 650                 655     


His Gly Pro Pro Ala Glu Gly Val Glu Arg Leu Ile Lys Tyr Ile Gly 
            660                 665                 670         


Tyr Lys Pro Glu Glu Tyr Lys Leu Gly Lys Thr Lys Ile Phe Ile Arg 
        675                 680                 685             


Phe Pro Arg Thr Leu Phe Ala Thr Glu Asp Ala Phe Glu Phe Ser Lys 
    690                 695                 700                 


His Gln Leu Val Ala Arg Ile Gln Ala Thr Tyr Lys Arg Cys Leu Gly 
705                 710                 715                 720 


Arg Arg Glu Tyr Val Lys Lys Arg Gln Ala Ala Ile Lys Leu Glu Ala 
                725                 730                 735     


His Trp Arg Gly Ala Leu Ala Arg Lys Ala Ile Gln Arg Arg Lys Trp 
            740                 745                 750         


Ala Val Arg Ile Ile Arg Lys Phe Ile Lys Gly Phe Ile Ser Arg Asn 
        755                 760                 765             


Lys Pro Leu Cys Pro Asp Asn Glu Glu Phe Ile Val Phe Val Arg Lys 
    770                 775                 780                 


Asn Tyr Ile Leu Asn Leu Arg Tyr His Leu Pro Lys Thr Val Leu Asp 
785                 790                 795                 800 


Lys Ser Trp Leu Arg Pro Pro Gly Ile Leu Glu Asn Ala Ser Asp Leu 
                805                 810                 815     


Leu Arg Lys Met Cys Val Arg Asn Leu Val Gln Lys Tyr Cys Arg Gly 
            820                 825                 830         


Ile Thr Ala Glu Arg Lys Ala Met Met Gln Gln Lys Val Val Thr Ser 
        835                 840                 845             


Glu Ile Phe Arg Gly Arg Lys Asp Gly Tyr Thr Glu Ser Leu Asn Gln 
    850                 855                 860                 


Pro Phe Val Asn Ser Arg Ile Asp Glu Gly Asp Ile Asn Pro Lys Val 
865                 870                 875                 880 


Leu Gln Leu Ile Ser His Glu Lys Ile Gln Tyr Gly Val Pro Val Ile 
                885                 890                 895     


Lys Tyr Asp Arg Lys Gly Phe Lys Ala Arg Gln Arg Gln Leu Ile Leu 
            900                 905                 910         


Thr Gln Lys Ala Ala Tyr Val Val Glu Leu Ala Lys Ile Lys Gln Lys 
        915                 920                 925             


Ile Glu Tyr Ser Ala Leu Lys Gly Val Ser Thr Ser Asn Leu Ser Asp 
    930                 935                 940                 


Gly Ile Leu Val Ile His Val Ser Pro Glu Asp Ser Lys Gln Lys Gly 
945                 950                 955                 960 


Asp Ala Val Leu Gln Cys Gly His Val Phe Glu Ala Val Thr Lys Leu 
                965                 970                 975     


Val Met Leu Val Lys Lys Glu Asn Ile Val Asn Val Val Gln Gly Ser 
            980                 985                 990         


Leu Gln Phe Phe Ile Ser Pro Gly  Lys Glu Gly Thr Ile  Val Phe Asp 
        995                 1000                 1005             


Thr Gly  Leu Glu Glu Gln Val  Tyr Lys Asn Lys Asn  Gly Gln Leu 
    1010                 1015                 1020             


Thr Val  Val Ser Val Arg Arg  Lys Ser 
    1025                 1030         


<210> 7634
<211> 391
<212> PRT
<213> Homo sapiens

<400> 7634
Met Cys Ser Gln Leu Trp Phe Leu Thr Asp Arg Arg Ile Arg Glu Asp 
1               5                   10                  15      


Tyr Pro Gln Val Gln Ile Leu Arg Ala Leu Arg Gln Arg Cys Ser Glu 
            20                  25                  30          


Gln Asp Val Arg Phe Arg Ala Val Leu Met Asp Gln Ile Ala Val Thr 
        35                  40                  45              


Ile Val Gly Gly His Leu Gly Leu Gln Leu Asn Gln Lys Ala Leu Thr 
    50                  55                  60                  


Thr Phe Pro Asp Val Val Leu Val Arg Val Pro Thr Pro Ser Val Gln 
65                  70                  75                  80  


Ser Asp Ser Asp Ile Thr Val Leu Arg His Leu Glu Lys Leu Gly Cys 
                85                  90                  95      


Arg Leu Val Asn Arg Pro Gln Ser Ile Leu Asn Cys Ile Asn Lys Phe 
            100                 105                 110         


Trp Thr Phe Gln Glu Leu Ala Gly His Gly Val Pro Met Pro Asp Thr 
        115                 120                 125             


Phe Ser Tyr Gly Gly His Glu Asp Phe Ser Lys Met Ile Asp Glu Ala 
    130                 135                 140                 


Glu Pro Leu Gly Tyr Pro Val Val Val Lys Ser Thr Arg Gly His Arg 
145                 150                 155                 160 


Gly Lys Ala Val Phe Leu Ala Arg Asp Lys His His Leu Ser Asp Ile 
                165                 170                 175     


Cys His Leu Ile Arg His Asp Val Pro Tyr Leu Phe Gln Lys Tyr Val 
            180                 185                 190         


Lys Glu Ser His Gly Lys Asp Ile Arg Val Val Val Val Gly Gly Gln 
        195                 200                 205             


Val Ile Gly Ser Met Leu Arg Cys Ser Thr Asp Gly Arg Met Gln Ser 
    210                 215                 220                 


Asn Cys Ser Leu Gly Gly Val Gly Val Lys Cys Pro Leu Thr Glu Gln 
225                 230                 235                 240 


Gly Lys Gln Leu Ala Ile Gln Val Ser Asn Ile Leu Gly Met Asp Phe 
                245                 250                 255     


Cys Gly Ile Asp Leu Leu Ile Met Asp Asp Gly Ser Phe Val Val Cys 
            260                 265                 270         


Glu Ala Asn Ala Asn Val Gly Phe Leu Ala Phe Asp Gln Ala Cys Asn 
        275                 280                 285             


Leu Asp Val Gly Gly Ile Ile Ala Asp Tyr Thr Met Ser Leu Leu Pro 
    290                 295                 300                 


Asn Arg Gln Thr Gly Lys Met Ala Val Leu Pro Gly Leu Ser Ser Pro 
305                 310                 315                 320 


Arg Glu Lys Asn Glu Pro Asp Gly Cys Ala Ser Ala Gln Gly Val Ala 
                325                 330                 335     


Glu Ser Val Tyr Thr Ile Asn Ser Gly Ser Thr Ser Ser Glu Ser Glu 
            340                 345                 350         


Pro Glu Leu Gly Glu Ile Arg Asp Ser Ser Ala Ser Thr Met Gly Ala 
        355                 360                 365             


Pro Pro Ser Met Leu Pro Glu Pro Gly Tyr Asn Ile Asn Asn Arg Ile 
    370                 375                 380                 


Ala Ser Glu Leu Lys Leu Lys 
385                 390     


<210> 7635
<211> 354
<212> PRT
<213> Homo sapiens

<400> 7635
Met Asp Met Asp His Ile Met Thr Trp Ala Thr Asp Val Ala Lys Gly 
1               5                   10                  15      


Met His Tyr Leu His Met Glu Ala Pro Val Lys Val Ile His Arg Asp 
            20                  25                  30          


Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp Gly Val Leu Lys Ile 
        35                  40                  45              


Cys Asp Phe Gly Ala Ser Arg Phe His Asn His Thr Thr His Met Ser 
    50                  55                  60                  


Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu Val Ile Gln Ser Leu 
65                  70                  75                  80  


Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr Gly Val Val Leu Trp 
                85                  90                  95      


Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly Leu Glu Gly Leu Gln 
            100                 105                 110         


Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg Leu Thr Ile Pro Ser 
        115                 120                 125             


Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His Gln Cys Trp Glu Ala 
    130                 135                 140                 


Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile Ile Ser Ile Leu Glu 
145                 150                 155                 160 


Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys Cys Asn Ser Phe Leu 
                165                 170                 175     


His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu Ala Thr Leu Glu Arg 
            180                 185                 190         


Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys Glu Gln Glu Leu Lys 
        195                 200                 205             


Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln Lys Leu Thr Glu Gln 
    210                 215                 220                 


Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala Arg Met Ser Glu Glu 
225                 230                 235                 240 


Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn Ser Ala Glu Met Ser 
                245                 250                 255     


Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly His Gly Met Asn Pro 
            260                 265                 270         


Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly Asp Ile Phe Ser Met 
        275                 280                 285             


Asn Lys Ala Gly Ala Val Met His Ser Gly Met Gln Ile Asn Met Gln 
    290                 295                 300                 


Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys Arg Arg Gly Lys Lys 
305                 310                 315                 320 


Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp Leu Ser Glu Gly Asp 
                325                 330                 335     


Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp Asn Asp Met Asp Asn 
            340                 345                 350         


Ser Glu 
        


<210> 7636
<211> 568
<212> PRT
<213> Homo sapiens

<400> 7636
Met Leu Glu Arg Pro Pro Ala Leu Ala Met Pro Met Pro Thr Glu Gly 
1               5                   10                  15      


Thr Pro Pro Pro Leu Ser Gly Thr Pro Ile Pro Val Pro Ala Tyr Phe 
            20                  25                  30          


Arg His Ala Glu Pro Gly Phe Ser Leu Lys Arg Pro Arg Gly Leu Ser 
        35                  40                  45              


Arg Ser Leu Pro Pro Pro Pro Pro Ala Lys Gly Ser Ile Pro Ile Ser 
    50                  55                  60                  


Arg Leu Phe Pro Pro Arg Thr Pro Gly Trp His Gln Leu Gln Pro Arg 
65                  70                  75                  80  


Arg Val Ser Phe Arg Gly Glu Ala Ser Glu Thr Leu Gln Ser Pro Gly 
                85                  90                  95      


Tyr Asp Pro Ser Arg Pro Glu Ser Phe Phe Gln Gln Ser Phe Gln Arg 
            100                 105                 110         


Leu Ser Arg Leu Gly His Gly Ser Tyr Gly Glu Val Phe Lys Val Arg 
        115                 120                 125             


Ser Lys Glu Asp Gly Arg Leu Tyr Ala Val Lys Arg Ser Met Ser Pro 
    130                 135                 140                 


Phe Arg Gly Pro Lys Asp Arg Ala Arg Lys Leu Ala Glu Val Gly Ser 
145                 150                 155                 160 


His Glu Lys Val Gly Gln His Pro Cys Cys Val Arg Leu Glu Gln Ala 
                165                 170                 175     


Trp Glu Glu Gly Gly Ile Leu Tyr Leu Gln Thr Glu Leu Cys Gly Pro 
            180                 185                 190         


Ser Leu Gln Gln His Cys Glu Ala Trp Gly Ala Ser Leu Pro Glu Ala 
        195                 200                 205             


Gln Val Trp Gly Tyr Leu Arg Asp Thr Leu Leu Ala Leu Ala His Leu 
    210                 215                 220                 


His Ser Gln Gly Leu Val His Leu Asp Val Lys Pro Ala Asn Ile Phe 
225                 230                 235                 240 


Leu Gly Pro Arg Gly Arg Cys Lys Leu Gly Asp Phe Gly Leu Leu Val 
                245                 250                 255     


Glu Leu Gly Thr Ala Gly Ala Gly Glu Val Gln Glu Gly Asp Pro Arg 
            260                 265                 270         


Tyr Met Ala Pro Glu Leu Leu Gln Gly Ser Tyr Gly Thr Ala Ala Asp 
        275                 280                 285             


Val Phe Ser Leu Gly Leu Thr Ile Leu Glu Val Ala Cys Asn Met Glu 
    290                 295                 300                 


Leu Pro His Gly Gly Glu Gly Trp Gln Gln Leu Arg Gln Gly Tyr Leu 
305                 310                 315                 320 


Pro Pro Glu Phe Thr Ala Gly Leu Ser Ser Glu Leu Arg Ser Val Leu 
                325                 330                 335     


Val Met Met Leu Glu Pro Asp Pro Lys Leu Arg Ala Thr Ala Glu Ala 
            340                 345                 350         


Leu Leu Ala Leu Pro Val Leu Arg Gln Pro Arg Ala Trp Gly Val Leu 
        355                 360                 365             


Trp Cys Met Ala Ala Glu Ala Leu Ser Arg Gly Trp Ala Leu Trp Gln 
    370                 375                 380                 


Ala Leu Leu Ala Leu Leu Cys Trp Leu Trp His Gly Leu Ala His Pro 
385                 390                 395                 400 


Ala Ser Trp Leu Gln Pro Leu Gly Pro Pro Ala Thr Pro Pro Gly Ser 
                405                 410                 415     


Pro Pro Cys Ser Leu Leu Leu Asp Ser Ser Leu Ser Ser Asn Trp Asp 
            420                 425                 430         


Asp Asp Ser Leu Gly Pro Ser Leu Ser Pro Glu Ala Val Leu Ala Arg 
        435                 440                 445             


Thr Val Gly Ser Thr Ser Thr Pro Arg Ser Arg Cys Thr Pro Arg Val 
    450                 455                 460                 


Leu Thr Pro Leu Arg Leu Ser Pro Ala Ala Glu Pro Ser Ala Pro Gly 
465                 470                 475                 480 


Leu Gly Pro Ala Ala Glu Ala Pro Cys Cys Val Glu Gln Arg Gly Phe 
                485                 490                 495     


Leu Ser Arg His Ile Pro Arg Ser Phe Ser Ala Phe Gln Ala Ala Pro 
            500                 505                 510         


Pro Lys Ser Ala Cys Asn Ala Leu His Leu His Gly His Thr Gln Pro 
        515                 520                 525             


Ser Ala Phe Val Trp Ser Leu Thr Cys Ser Ser His His Gly Arg Thr 
    530                 535                 540                 


Phe Glu Ala Arg Thr Lys Val Asp Pro Leu Phe Lys Ile Cys Gly Gly 
545                 550                 555                 560 


Phe Leu Thr Val Phe Ala Asp Leu 
                565             


<210> 7637
<211> 213
<212> PRT
<213> Homo sapiens

<400> 7637
Met Ala Glu Thr Glu Glu Arg Ser Leu Asp Asn Phe Phe Ala Lys Arg 
1               5                   10                  15      


Asp Lys Lys Lys Lys Lys Glu Arg Ser Asn Arg Ala Ala Ser Ala Ala 
            20                  25                  30          


Gly Ala Ala Gly Ser Ala Gly Gly Ser Ser Gly Ala Ala Gly Ala Ala 
        35                  40                  45              


Gly Gly Gly Ala Gly Ala Gly Thr Arg Pro Gly Asp Gly Gly Thr Ala 
    50                  55                  60                  


Ser Ala Gly Ala Ala Gly Pro Gly Ala Ala Thr Lys Ala Val Thr Lys 
65                  70                  75                  80  


Asp Glu Asp Glu Trp Lys Glu Leu Glu Gln Lys Glu Val Asp Tyr Ser 
                85                  90                  95      


Gly Leu Arg Val Gln Ala Met Gln Ile Ser Ser Glu Lys Glu Glu Asp 
            100                 105                 110         


Asp Asn Glu Lys Arg Gln Asp Pro Gly Asp Asn Trp Glu Glu Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Met Glu Lys Ser Ser Gly Pro Trp Asn Lys Thr 
    130                 135                 140                 


Ala Pro Val Gln Ala Pro Pro Ala Pro Val Ile Val Thr Glu Thr Pro 
145                 150                 155                 160 


Glu Pro Ala Met Thr Ser Gly Val Tyr Arg Pro Pro Gly Ala Arg Leu 
                165                 170                 175     


Thr Thr Thr Arg Lys Thr Pro Gln Gly Pro Pro Glu Ile Tyr Ser Asp 
            180                 185                 190         


Thr Gln Phe Pro Ser Leu Gln Ser Thr Ala Lys His Val Glu Ser Arg 
        195                 200                 205             


Asn Arg Tyr Leu Lys 
    210             


<210> 7638
<211> 1379
<212> PRT
<213> Homo sapiens

<400> 7638
Met Ala Ser Ser Pro Thr Lys Gly Leu Thr Met Ser Val Pro Val Ala 
1               5                   10                  15      


Pro Lys Lys Ser Cys Tyr Thr Gln Leu Arg Asp Asn Arg Asn Ala Ala 
            20                  25                  30          


Arg Asn Asn Asn Glu Ser Ile Leu Ser Leu Gly Asp Thr Asn Ala Asn 
        35                  40                  45              


Gln Ile Met Leu Glu Val Ser Ser Ser His Asp Glu Ser Lys Thr Cys 
    50                  55                  60                  


Asp Leu Gly Asp Glu Ile Gly Asn Thr Asn Ser Ser Glu Pro Glu Asn 
65                  70                  75                  80  


Arg Thr His Phe His Lys Glu Phe His Gln Leu Gln Gly Phe Gly Lys 
                85                  90                  95      


Gly Ser Gln Ala Gly Ser Ala Ser Leu Lys Asp Phe Arg Leu Ser Ser 
            100                 105                 110         


Thr Ile Gln Arg Glu Leu Asn Glu Glu His Thr Val Glu Arg Gly Thr 
        115                 120                 125             


Asp Ser Leu Gln Thr Thr Arg Ser Ile Gln Gly Pro Ser Leu Ser Ser 
    130                 135                 140                 


Trp Arg Asn Val Met Ser Glu Ala Ser Leu Asp Val Leu Ala Lys Arg 
145                 150                 155                 160 


Asp Ala Glu Ile Pro Arg His Val Pro Lys Asp Lys Leu Ala Lys Thr 
                165                 170                 175     


Leu Asp Asn Glu Glu Leu Arg Arg His Ser Leu Glu Arg Ala Ser Ser 
            180                 185                 190         


Ser Val Ala Ala Val Gly Ser Leu Thr Pro Gln His Pro Gln Pro Leu 
        195                 200                 205             


Ser Leu Asp Ser Arg Glu Ala Arg Gly Gln Ile Pro Gly Gly Gly Glu 
    210                 215                 220                 


Gly Pro Gln Lys Thr Leu Pro Asp His Ala Val Pro Ala Ala Phe Pro 
225                 230                 235                 240 


Ala Thr Asp Ser Thr Ser Glu Gly Lys Ser Val Arg His Pro Lys Pro 
                245                 250                 255     


Ser Thr Ser Glu Ser Lys Gln Ser Thr Pro Ser Glu Thr Gln Thr Val 
            260                 265                 270         


Gly Ala His Val Leu Gln Val Cys Ser Glu His Thr Ser His Ser Ala 
        275                 280                 285             


His Pro Glu Pro Ala Leu Asn Leu Thr Leu Ala Ser Lys Glu Ile Pro 
    290                 295                 300                 


Ser Lys Leu Glu Ala Gln Leu Gly Gln Gly Lys Gly Glu Ala Lys Leu 
305                 310                 315                 320 


Asp Leu Lys Tyr Val Pro Pro Arg Arg Val Glu Gln Glu Gly Lys Ala 
                325                 330                 335     


Ala Gln Glu Gly Tyr Leu Gly Cys His Lys Glu Glu Asn Leu Ser Ala 
            340                 345                 350         


Leu Glu Gly Arg Asp Pro Cys Gly Glu Ala His Pro Glu Ala Thr Asp 
        355                 360                 365             


Ala Leu Gly His Leu Leu Asn Ser Asp Leu His His Leu Gly Val Gly 
    370                 375                 380                 


Arg Gly Asn Cys Glu Glu Lys Arg Gly Val Asn Pro Gly Glu Gln Asp 
385                 390                 395                 400 


Ser Leu His Thr Thr Pro Lys Gln Gly Ser Ala Ser Leu Gly Gly Ala 
                405                 410                 415     


Asp Asn Gln Pro Thr Gly Lys Ile Ser Pro Cys Ala Gly Glu Lys Leu 
            420                 425                 430         


Gly Glu Arg Thr Ser Ser Ser Phe Ser Pro Gly Asp Ser His Val Ala 
        435                 440                 445             


Phe Ile Pro Asn Asn Leu Thr Asp Ser Lys Pro Leu Asp Val Ile Glu 
    450                 455                 460                 


Glu Glu Arg Arg Leu Gly Ser Gly Asn Lys Asp Ser Val Met Val Leu 
465                 470                 475                 480 


Val Phe Asn Pro Ser Val Gly Glu Asn Lys Thr Glu Val Pro Glu Pro 
                485                 490                 495     


Leu Asp Pro Gln Ser Gly Arg Ser Glu Ala Arg Glu Ser Lys Glu Val 
            500                 505                 510         


Thr Thr Ser Val Ala Glu Asn Arg Asn Leu Leu Glu Asn Ala Asp Lys 
        515                 520                 525             


Ile Glu Ser Thr Ser Ala Arg Ala Asp Ser Val Leu Asn Ile Pro Ala 
    530                 535                 540                 


Pro Leu His Pro Glu Thr Thr Val Asn Met Thr Tyr Gln Pro Thr Thr 
545                 550                 555                 560 


Pro Ser Ser Ser Phe Gln Asp Val Ser Val Phe Gly Met Asp Ala Gly 
                565                 570                 575     


Ser Pro Leu Val Val Pro Pro Pro Thr Asp Ser Ala Arg Leu Leu Asn 
            580                 585                 590         


Thr Ser Pro Lys Val Pro Asp Lys Asn Thr Cys Pro Ser Gly Ile Pro 
        595                 600                 605             


Lys Pro Val Phe Thr His Ser Lys Asp Thr Pro Ser Ser Gln Glu Gly 
    610                 615                 620                 


Met Glu Asn Tyr Gln Val Glu Lys Thr Glu Glu Arg Thr Glu Thr Lys 
625                 630                 635                 640 


Pro Ile Ile Met Pro Lys Pro Lys His Val Arg Pro Lys Ile Ile Thr 
                645                 650                 655     


Tyr Ile Arg Arg Asn Pro Gln Ala Leu Gly Gln Val Asp Ala Ser Leu 
            660                 665                 670         


Val Pro Val Gly Leu Pro Tyr Ala Pro Pro Thr Cys Thr Met Pro Leu 
        675                 680                 685             


Pro His Glu Glu Lys Ala Ala Gly Gly Asp Leu Lys Pro Ser Ala Asn 
    690                 695                 700                 


Leu Tyr Glu Lys Phe Lys Pro Asp Leu Gln Lys Pro Arg Val Phe Ser 
705                 710                 715                 720 


Ser Gly Leu Met Val Ser Gly Ile Lys Pro Pro Gly His Pro Phe Ser 
                725                 730                 735     


Gln Met Ser Glu Lys Phe Leu Gln Glu Val Thr Asp His Pro Gly Lys 
            740                 745                 750         


Glu Glu Phe Cys Ser Pro Pro Tyr Ala His Tyr Glu Val Pro Pro Thr 
        755                 760                 765             


Phe Tyr Arg Ser Ala Met Leu Leu Lys Pro Gln Leu Gly Leu Gly Ala 
    770                 775                 780                 


Met Ser Arg Leu Pro Ser Ala Lys Ser Arg Ile Leu Ile Ala Ser Gln 
785                 790                 795                 800 


Arg Ser Ser Ala Ser Ala Ile His Pro Pro Gly Pro Ile Thr Thr Ala 
                805                 810                 815     


Thr Ser Leu Tyr Ser Ser Asp Pro Ser Ala Asp Leu Lys Lys Ala Ser 
            820                 825                 830         


Ser Ser Asn Ala Ala Lys Ser Asn Leu Pro Lys Ser Gly Leu Arg Pro 
        835                 840                 845             


Pro Gly Tyr Ser Arg Leu Pro Ala Ala Lys Leu Ala Ala Phe Gly Phe 
    850                 855                 860                 


Val Arg Ser Ser Ser Val Ser Ser Val Ser Ser Thr Gln Ser Gly Asp 
865                 870                 875                 880 


Ser Ala Gln Pro Glu Gln Gly Arg Pro Ala Thr Arg Ser Thr Phe Gly 
                885                 890                 895     


Asn Glu Glu Gln Pro Val Leu Lys Ala Ser Leu Pro Ser Lys Asp Thr 
            900                 905                 910         


Pro Lys Gly Ala Gly Arg Val Ala Pro Pro Ala Ser Ser Ser Val Thr 
        915                 920                 925             


Ala Pro Arg Arg Ser Leu Leu Pro Ala Pro Lys Ser Thr Ser Thr Pro 
    930                 935                 940                 


Ala Gly Thr Lys Lys Asp Ala Gln Lys Asp Gln Asp Thr Asn Lys Pro 
945                 950                 955                 960 


Ala Val Ser Ser Pro Lys Arg Val Ala Ala Ser Thr Thr Lys Leu His 
                965                 970                 975     


Ser Pro Gly Tyr Pro Lys Gln Arg Thr Ala Ala Ala Arg Asn Gly Phe 
            980                 985                 990         


Pro Pro Lys Pro Asp Pro Gln Ala  Arg Glu Ala Glu Arg  Gln Leu Val 
        995                 1000                 1005             


Leu Arg  Leu Lys Glu Arg Cys  Glu Gln Gln Thr Arg  Gln Leu Gly 
    1010                 1015                 1020             


Val Ala  Gln Gly Glu Leu Lys  Arg Ala Ile Cys Gly  Phe Asp Ala 
    1025                 1030                 1035             


Leu Ala  Val Ala Thr Gln His  Phe Phe Arg Lys Asn  Glu Ser Ala 
    1040                 1045                 1050             


Leu Val  Lys Glu Lys Glu Leu  Ser Ile Glu Leu Ala  Asn Ile Arg 
    1055                 1060                 1065             


Asp Glu  Val Ala Phe His Thr  Ala Lys Cys Glu Lys  Leu Gln Lys 
    1070                 1075                 1080             


Glu Lys  Glu Glu Leu Glu Arg  Arg Phe Glu Asp Glu  Val Lys Arg 
    1085                 1090                 1095             


Leu Gly  Trp Gln Gln Gln Ala  Glu Leu Gln Glu Leu  Glu Glu Arg 
    1100                 1105                 1110             


Leu Gln  Leu Gln Phe Glu Ala  Glu Met Ala Arg Leu  Gln Glu Glu 
    1115                 1120                 1125             


His Gly  Asp Gln Leu Leu Ser  Ile Arg Cys Gln His  Gln Glu Gln 
    1130                 1135                 1140             


Val Glu  Asp Leu Thr Ala Ser  His Asp Ala Ala Leu  Leu Glu Met 
    1145                 1150                 1155             


Glu Asn  Asn His Thr Val Ala  Ile Thr Ile Leu Gln  Asp Asp His 
    1160                 1165                 1170             


Asp His  Lys Val Gln Glu Leu  Met Ser Thr His Glu  Leu Glu Lys 
    1175                 1180                 1185             


Lys Glu  Leu Glu Glu Asn Phe  Glu Lys Leu Arg Leu  Ser Leu Gln 
    1190                 1195                 1200             


Asp Gln  Val Asp Thr Leu Thr  Phe Gln Ser Gln Ser  Leu Arg Asp 
    1205                 1210                 1215             


Arg Ala  Arg Arg Phe Glu Glu  Ala Leu Arg Lys Asn  Thr Glu Glu 
    1220                 1225                 1230             


Gln Leu  Glu Ile Ala Leu Ala  Pro Tyr Gln His Leu  Glu Glu Asp 
    1235                 1240                 1245             


Met Lys  Ser Leu Lys Gln Val  Leu Glu Met Lys Asn  Gln Gln Ile 
    1250                 1255                 1260             


His Glu  Gln Glu Lys Lys Ile  Leu Glu Leu Glu Lys  Leu Ala Glu 
    1265                 1270                 1275             


Lys Asn  Ile Ile Leu Glu Glu  Lys Ile Gln Val Leu  Gln Gln Gln 
    1280                 1285                 1290             


Asn Glu  Asp Leu Lys Ala Arg  Ile Asp Gln Asn Thr  Val Val Thr 
    1295                 1300                 1305             


Arg Gln  Leu Ser Glu Glu Asn  Ala Asn Leu Gln Glu  Tyr Val Glu 
    1310                 1315                 1320             


Lys Glu  Thr Gln Glu Lys Lys  Arg Leu Ser Arg Thr  Asn Glu Glu 
    1325                 1330                 1335             


Leu Leu  Trp Lys Leu Gln Thr  Gly Asp Pro Thr Ser  Pro Ile Lys 
    1340                 1345                 1350             


Leu Ser  Pro Thr Ser Pro Val  Tyr Arg Gly Ser Ser  Ser Gly Pro 
    1355                 1360                 1365             


Ser Ser  Pro Ala Arg Val Ser  Thr Thr Pro Arg 
    1370                 1375                 


<210> 7639
<211> 346
<212> PRT
<213> Homo sapiens

<400> 7639
Met Gln His Leu Lys Ser Lys Lys Arg Glu Glu Arg Trp Met Arg Ala 
1               5                   10                  15      


Ser Lys Arg Gln Ser Glu Lys Glu Met Glu Glu Leu His His Asn Ile 
            20                  25                  30          


Asp Asp Leu Leu Gln Glu Lys Lys Ser Leu Glu Cys Glu Val Glu Glu 
        35                  40                  45              


Leu His Arg Thr Val Gln Lys Arg Gln Gln Gln Lys Asp Phe Ile Asp 
    50                  55                  60                  


Gly Asn Val Glu Ser Leu Met Thr Glu Leu Glu Ile Glu Lys Ser Leu 
65                  70                  75                  80  


Lys His His Glu Asp Ile Val Asp Glu Ile Glu Cys Ile Glu Lys Thr 
                85                  90                  95      


Leu Leu Lys Arg Arg Ser Glu Leu Arg Glu Ala Asp Arg Leu Leu Ala 
            100                 105                 110         


Glu Ala Glu Ser Glu Leu Ser Cys Thr Lys Glu Lys Thr Lys Asn Ala 
        115                 120                 125             


Val Glu Lys Phe Thr Asp Ala Lys Arg Ser Leu Leu Gln Thr Glu Ser 
    130                 135                 140                 


Asp Ala Glu Glu Leu Glu Arg Arg Ala Gln Glu Thr Ala Val Asn Leu 
145                 150                 155                 160 


Val Lys Ala Asp Gln Gln Leu Arg Ser Leu Gln Ala Asp Ala Lys Asp 
                165                 170                 175     


Leu Glu Gln His Lys Ile Lys Gln Glu Glu Ile Leu Lys Glu Ile Asn 
            180                 185                 190         


Lys Ile Val Ala Ala Lys Asp Ser Asp Phe Gln Cys Leu Ser Lys Lys 
        195                 200                 205             


Lys Glu Lys Leu Thr Glu Glu Leu Gln Lys Leu Gln Lys Asp Ile Glu 
    210                 215                 220                 


Met Ala Glu Arg Asn Glu Asp His His Leu Gln Val Leu Lys Glu Ser 
225                 230                 235                 240 


Glu Val Leu Leu Gln Ala Lys Arg Ala Glu Leu Glu Lys Leu Lys Ser 
                245                 250                 255     


Gln Val Thr Ser Gln Gln Gln Glu Met Ala Val Leu Asp Arg Gln Leu 
            260                 265                 270         


Gly His Lys Lys Glu Glu Leu His Leu Leu Gln Gly Ser Met Val Gln 
        275                 280                 285             


Ala Lys Ala Asp Leu Gln Glu Ala Leu Arg Leu Gly Glu Thr Glu Val 
    290                 295                 300                 


Thr Glu Lys Cys Asn His Ile Arg Glu Val Lys Ser Leu Leu Glu Glu 
305                 310                 315                 320 


Leu Ser Phe Gln Lys Gly Glu Leu Asn Val Gln Ile Ser Glu Arg Lys 
                325                 330                 335     


Thr Gln Leu Thr Leu Ile Lys Gln Glu Ile 
            340                 345     


<210> 7640
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7640
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7641
<211> 96
<212> PRT
<213> Homo sapiens

<400> 7641
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln Thr Arg Gln 
                85                  90                  95      


<210> 7642
<211> 970
<212> PRT
<213> Homo sapiens

<400> 7642
Met Leu Gln Gln Val Asn Gly His Asn Pro Gly Ser Asp Gly Gln Ala 
1               5                   10                  15      


Arg Glu Tyr Leu Arg Glu Asp Leu Gln Glu Phe Leu Gly Gly Glu Val 
            20                  25                  30          


Leu Leu Tyr Lys Leu Asp Asp Leu Thr Arg Val Asn Pro Val Thr Leu 
        35                  40                  45              


Glu Thr Val Leu Arg Cys Leu Gln Ala Arg Tyr Met Ala Asp Thr Phe 
    50                  55                  60                  


Tyr Thr Asn Ala Gly Cys Thr Leu Val Ala Leu Asn Pro Phe Lys Pro 
65                  70                  75                  80  


Val Pro Gln Leu Tyr Ser Pro Glu Leu Met Arg Glu Tyr His Ala Ala 
                85                  90                  95      


Pro Gln Pro Gln Lys Leu Lys Pro His Val Phe Thr Val Gly Glu Gln 
            100                 105                 110         


Thr Tyr Arg Asn Val Lys Ser Leu Ile Glu Pro Val Asn Gln Ser Ile 
        115                 120                 125             


Val Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Trp Thr Ser Arg Cys 
    130                 135                 140                 


Leu Met Lys Phe Tyr Ala Val Val Ala Thr Ser Pro Ala Ser Trp Glu 
145                 150                 155                 160 


Ser His Lys Ile Ala Glu Arg Ile Glu Gln Arg Ile Leu Asn Ser Asn 
                165                 170                 175     


Pro Val Met Glu Ala Phe Gly Asn Ala Cys Thr Leu Arg Asn Asn Asn 
            180                 185                 190         


Ser Ser Arg Phe Gly Lys Phe Ile Gln Leu Gln Leu Asn Arg Ala Gln 
        195                 200                 205             


Gln Met Thr Gly Ala Ala Val Gln Thr Tyr Leu Leu Glu Lys Thr Arg 
    210                 215                 220                 


Val Ala Cys Gln Ala Ser Ser Glu Arg Asn Phe His Ile Phe Tyr Gln 
225                 230                 235                 240 


Ile Cys Lys Gly Ala Ser Glu Asp Glu Arg Leu Gln Trp His Leu Pro 
                245                 250                 255     


Glu Gly Ala Ala Phe Ser Trp Leu Pro Asn Pro Glu Arg Ser Leu Glu 
            260                 265                 270         


Glu Asp Cys Phe Glu Val Thr Arg Glu Ala Met Leu His Leu Gly Ile 
        275                 280                 285             


Asp Thr Pro Thr Gln Asn Asn Ile Phe Lys Val Leu Ala Gly Leu Leu 
    290                 295                 300                 


His Leu Gly Asn Ile Gln Phe Ala Ala Ser Glu Asp Glu Ala Gln Pro 
305                 310                 315                 320 


Cys Gln Pro Met Asp Asp Ala Lys Tyr Ser Val Arg Thr Ala Ala Ser 
                325                 330                 335     


Leu Leu Gly Leu Pro Glu Asp Val Leu Leu Glu Met Val Gln Ile Arg 
            340                 345                 350         


Thr Ile Arg Ala Gly Arg Gln Gln Gln Val Phe Arg Lys Pro Cys Ala 
        355                 360                 365             


Arg Ala Glu Cys Asp Thr Arg Arg Asp Cys Leu Ala Lys Leu Ile Tyr 
    370                 375                 380                 


Ala Arg Leu Phe Asp Trp Leu Val Ser Val Ile Asn Ser Ser Ile Cys 
385                 390                 395                 400 


Ala Asp Thr Asp Ser Trp Thr Thr Phe Ile Gly Leu Leu Asp Val Tyr 
                405                 410                 415     


Gly Phe Glu Ser Phe Pro Asp Asn Ser Leu Glu Gln Leu Cys Ile Asn 
            420                 425                 430         


Tyr Ala Asn Glu Lys Leu Gln Gln His Phe Val Ala His Tyr Leu Arg 
        435                 440                 445             


Ala Gln Gln Glu Glu Tyr Ala Val Glu Gly Leu Glu Trp Ser Phe Ile 
    450                 455                 460                 


Asn Tyr Gln Asp Asn Gln Pro Cys Leu Asp Leu Ile Glu Gly Ser Pro 
465                 470                 475                 480 


Ile Ser Ile Cys Ser Leu Ile Asn Glu Glu Cys Arg Leu Asn Arg Pro 
                485                 490                 495     


Ser Ser Ala Ala Gln Leu Gln Thr Arg Ile Glu Thr Ala Leu Ala Gly 
            500                 505                 510         


Ser Pro Cys Leu Gly His Asn Lys Leu Ser Arg Glu Pro Ser Phe Ile 
        515                 520                 525             


Val Val His Tyr Ala Gly Pro Val Arg Tyr His Thr Ala Gly Leu Val 
    530                 535                 540                 


Glu Lys Asn Lys Asp Pro Ile Pro Pro Glu Leu Thr Arg Leu Leu Gln 
545                 550                 555                 560 


Gln Ser Gln Asp Pro Leu Leu Met Gly Leu Phe Pro Thr Asn Pro Lys 
                565                 570                 575     


Glu Lys Thr Gln Glu Glu Pro Pro Gly Gln Ser Arg Ala Pro Val Leu 
            580                 585                 590         


Thr Val Val Ser Lys Phe Lys Ala Ser Leu Glu Gln Leu Leu Gln Val 
        595                 600                 605             


Leu His Ser Thr Thr Pro His Tyr Ile Arg Cys Ile Lys Pro Asn Ser 
    610                 615                 620                 


Gln Gly Gln Ala Gln Thr Phe Leu Gln Glu Glu Val Leu Ser Gln Leu 
625                 630                 635                 640 


Glu Ala Cys Gly Leu Val Glu Thr Ile His Ile Ser Ala Ala Gly Phe 
                645                 650                 655     


Pro Ile Arg Val Ser His Arg Asn Phe Val Glu Arg Tyr Lys Leu Leu 
            660                 665                 670         


Arg Arg Leu His Pro Cys Thr Ser Ser Gly Pro Asp Ser Pro Tyr Pro 
        675                 680                 685             


Ala Lys Gly Leu Pro Glu Trp Cys Pro His Ser Glu Glu Ala Thr Leu 
    690                 695                 700                 


Glu Pro Leu Ile Gln Asp Ile Leu His Thr Leu Pro Val Leu Thr Gln 
705                 710                 715                 720 


Ala Ala Ala Ile Thr Gly Asp Ser Ala Glu Ala Met Pro Ala Pro Met 
                725                 730                 735     


His Cys Gly Arg Thr Lys Val Phe Met Thr Asp Ser Met Leu Glu Leu 
            740                 745                 750         


Leu Glu Cys Gly Arg Ala Arg Val Leu Glu Gln Cys Ala Arg Cys Ile 
        755                 760                 765             


Gln Gly Gly Trp Arg Arg His Arg His Arg Glu Gln Glu Arg Gln Trp 
    770                 775                 780                 


Arg Ala Val Met Leu Ile Gln Ala Ala Ile Arg Ser Trp Leu Thr Arg 
785                 790                 795                 800 


Lys His Ile Gln Arg Leu His Ala Ala Ala Thr Val Ile Lys Arg Ala 
                805                 810                 815     


Trp Gln Lys Trp Arg Ile Arg Met Ala Cys Leu Ala Ala Lys Glu Leu 
            820                 825                 830         


Asp Gly Val Glu Glu Lys His Phe Ser Gln Ala Pro Cys Ser Leu Ser 
        835                 840                 845             


Thr Ser Pro Leu Gln Thr Arg Leu Leu Glu Ala Ile Ile Arg Leu Trp 
    850                 855                 860                 


Pro Leu Gly Leu Val Leu Ala Asn Thr Ala Met Gly Val Gly Ser Phe 
865                 870                 875                 880 


Gln Arg Lys Leu Val Val Trp Ala Cys Leu Gln Leu Pro Arg Gly Ser 
                885                 890                 895     


Pro Ser Ser Tyr Thr Val Gln Thr Ala Gln Asp Gln Ala Gly Val Thr 
            900                 905                 910         


Ser Ile Arg Ala Leu Pro Gln Gly Ser Ile Lys Phe His Cys Arg Lys 
        915                 920                 925             


Ser Pro Leu Arg Tyr Ala Asp Ile Cys Pro Glu Pro Ser Pro Tyr Ser 
    930                 935                 940                 


Ile Thr Gly Phe Asn Gln Ile Leu Leu Glu Arg His Arg Leu Ile His 
945                 950                 955                 960 


Val Thr Ser Ser Ala Phe Thr Gly Leu Gly 
                965                 970 


<210> 7643
<211> 1100
<212> PRT
<213> Homo sapiens

<400> 7643
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp 
                85                  90                  95      


Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Asp 
            100                 105                 110         


Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn Ala Gly Leu 
        115                 120                 125             


Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln 
    130                 135                 140                 


Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala 
145                 150                 155                 160 


Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro 
                165                 170                 175     


Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp 
            180                 185                 190         


Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu 
        195                 200                 205             


Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln 
    210                 215                 220                 


His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu 
225                 230                 235                 240 


Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg 
                245                 250                 255     


Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln 
            260                 265                 270         


Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser 
        275                 280                 285             


Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser 
    290                 295                 300                 


Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro Ser Leu Cys Ser 
305                 310                 315                 320 


Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu Asp Tyr Cys Ser 
                325                 330                 335     


Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser Pro Arg Ala Ile 
            340                 345                 350         


Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp 
        355                 360                 365             


Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys Ser Arg Ser Cys 
    370                 375                 380                 


Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro Asp Pro Lys Val 
385                 390                 395                 400 


Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu Asp Ser Lys Glu 
                405                 410                 415     


Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro Glu Val Arg Ser 
            420                 425                 430         


Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg Asn Ala Pro Gly 
        435                 440                 445             


Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu 
    450                 455                 460                 


Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr 
465                 470                 475                 480 


Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala Trp Ser Gln Cys 
                485                 490                 495     


Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr Arg Ile Ser Glu 
            500                 505                 510         


Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp 
        515                 520                 525             


Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys 
    530                 535                 540                 


Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu Glu Glu Asn Gln 
545                 550                 555                 560 


Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln Ser Asn Ala Leu 
                565                 570                 575     


Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Ala His 
            580                 585                 590         


Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser 
        595                 600                 605             


Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser Glu Ser Asp Phe 
    610                 615                 620                 


Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His 
625                 630                 635                 640 


His His His His His His His His His His Arg His Leu Ile Ser Ser 
                645                 650                 655     


Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu 
            660                 665                 670         


Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu Pro Arg Arg Gln 
        675                 680                 685             


Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val 
    690                 695                 700                 


Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys Gln Thr Glu Lys 
705                 710                 715                 720 


Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp Ser Ala Leu Lys 
                725                 730                 735     


Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg Gly Ser Leu Pro 
            740                 745                 750         


Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Asp Val 
        755                 760                 765             


Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg Ser Pro Leu His 
    770                 775                 780                 


Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile His Cys Pro Pro 
785                 790                 795                 800 


Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala Ser Phe Gln Asp 
                805                 810                 815     


Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp Arg Gly Gly Ala 
            820                 825                 830         


Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp 
        835                 840                 845             


Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu 
    850                 855                 860                 


Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
865                 870                 875                 880 


Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
                885                 890                 895     


Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
            900                 905                 910         


Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
        915                 920                 925             


Ala Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile 
    930                 935                 940                 


Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
945                 950                 955                 960 


Lys Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
                965                 970                 975     


Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
            980                 985                 990         


Tyr Val Glu Val Val Lys Lys Asn  Thr Lys Gly Ala Glu  Asp Tyr Pro 
        995                 1000                 1005             


Asp Pro  Pro Ile Pro His Ser  Tyr Ser Ser Asp Arg  Ile His Ser 
    1010                 1015                 1020             


Leu Ser  Ser Asn Lys Pro Gln  Arg Pro Val Phe Thr  His Glu Asn 
    1025                 1030                 1035             


Ile Gln  Gly Gly Gly Glu Pro  Phe Gln Ala Leu Tyr  Asn Tyr Thr 
    1040                 1045                 1050             


Pro Arg  Asn Glu Asp Glu Leu  Glu Leu Arg Glu Ser  Asp Val Ile 
    1055                 1060                 1065             


Asp Val  Met Glu Lys Cys Asp  Asp Gly Trp Phe Val  Gly Thr Ser 
    1070                 1075                 1080             


Arg Arg  Thr Lys Phe Phe Gly  Thr Phe Pro Gly Asn  Tyr Val Lys 
    1085                 1090                 1095             


Arg Leu  
    1100 


<210> 7644
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7644
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7645
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7645
Met Ser Leu His Gly Lys Arg Lys Glu Ile Tyr Lys Tyr Glu Ala Pro 
1               5                   10                  15      


Trp Thr Val Tyr Ala Met Asn Trp Ser Val Arg Pro Asp Lys Arg Phe 
            20                  25                  30          


Arg Leu Ala Leu Gly Ser Phe Val Glu Glu Tyr Asn Asn Lys Val Gln 
        35                  40                  45              


Leu Val Gly Leu Asp Glu Glu Ser Ser Glu Phe Ile Cys Arg Asn Thr 
    50                  55                  60                  


Phe Asp His Pro Tyr Pro Thr Thr Lys Leu Met Trp Ile Pro Asp Thr 
65                  70                  75                  80  


Lys Gly Val Tyr Pro Asp Leu Leu Ala Thr Ser Gly Asp Tyr Leu Arg 
                85                  90                  95      


Val Trp Arg Val Gly Glu Thr Glu Thr Arg Leu Glu Cys Leu Leu Asn 
            100                 105                 110         


Asn Asn Lys Asn Ser Asp Phe Cys Ala Pro Leu Thr Ser Phe Asp Trp 
        115                 120                 125             


Asn Glu Val Asp Pro Tyr Leu Leu Gly Thr Ser Ser Ile Asp Thr Thr 
    130                 135                 140                 


Cys Cys Phe Gln Trp Pro Val Cys Leu Ser Leu Leu Cys Thr His Cys 
145                 150                 155                 160 


Tyr Gln Lys Leu Leu 
                165 


<210> 7646
<211> 347
<212> PRT
<213> Homo sapiens

<400> 7646
Met Ser Leu Ala Gln Ser Pro Gly Ile Trp Gly Glu Asp Pro Val Lys 
1               5                   10                  15      


Leu Thr Leu Ala Leu Lys Met Thr Arg Gln Asp Leu Thr Arg Thr Gln 
            20                  25                  30          


Met Glu Leu Asn Asn Met Lys Ala Asn Phe Gly Asp Val Val Pro Arg 
        35                  40                  45              


Arg Asp Phe Glu Met Gln Glu Lys Thr Asn Lys Asp Leu Gln Glu Gln 
    50                  55                  60                  


Leu Asp Thr Leu Arg Ala Ser Tyr Glu Glu Val Arg Lys Glu His Glu 
65                  70                  75                  80  


Ile Leu Met Gln Leu His Met Ser Thr Leu Lys Glu Arg Asp Gln Phe 
                85                  90                  95      


Phe Ser Glu Leu Gln Glu Ile Gln Arg Thr Ser Thr Pro Arg Pro Asp 
            100                 105                 110         


Trp Thr Lys Cys Lys Asp Val Val Ala Gly Gly Pro Glu Arg Trp Gln 
        115                 120                 125             


Met Leu Ala Glu Gly Lys Asn Ser Asp Gln Leu Val Asp Val Leu Leu 
    130                 135                 140                 


Glu Glu Ile Gly Ser Gly Leu Leu Arg Glu Lys Asp Phe Phe Pro Gly 
145                 150                 155                 160 


Leu Gly Tyr Gly Glu Ala Ile Pro Ala Phe Leu Arg Phe Asp Gly Leu 
                165                 170                 175     


Val Glu Asn Lys Lys Pro Ser Lys Lys Asp Val Val Asn Leu Leu Lys 
            180                 185                 190         


Asp Ala Trp Lys Glu Arg Leu Ala Glu Glu Gln Lys Glu Thr Phe Pro 
        195                 200                 205             


Asp Phe Phe Phe Asn Phe Leu Glu His Arg Phe Gly Pro Ser Asp Ala 
    210                 215                 220                 


Met Ala Trp Ala Tyr Thr Ile Phe Glu Asn Ile Lys Ile Phe His Ser 
225                 230                 235                 240 


Asn Glu Val Met Ser Gln Phe Tyr Ala Val Leu Met Gly Lys Arg Ser 
                245                 250                 255     


Glu Asn Val Tyr Val Thr Gln Lys Glu Thr Val Ala Gln Leu Leu Lys 
            260                 265                 270         


Glu Met Thr Asn Ala Asp Ser Gln Asn Glu Gly Leu Leu Thr Met Glu 
        275                 280                 285             


Gln Phe Asn Thr Val Leu Lys Ser Thr Phe Pro Leu Lys Thr Glu Glu 
    290                 295                 300                 


Gln Ile Gln Glu Leu Met Glu Ala Gly Gly Trp His Pro Ser Ser Ser 
305                 310                 315                 320 


Asn Ala Asp Leu Leu Asn Tyr Arg Ser Leu Phe Met Glu Asp Glu Glu 
                325                 330                 335     


Gly Gln Ser Glu Pro Phe Val Gln Lys Leu Trp 
            340                 345         


<210> 7647
<211> 72
<212> PRT
<213> Homo sapiens

<400> 7647
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr 
65                  70          


<210> 7648
<211> 382
<212> PRT
<213> Homo sapiens

<400> 7648
Met Leu Arg Trp Thr Val His Leu Glu Gly Gly Pro Arg Arg Val Asn 
1               5                   10                  15      


His Ala Ala Val Ala Val Gly His Arg Val Tyr Ser Phe Gly Gly Tyr 
            20                  25                  30          


Cys Ser Gly Glu Asp Tyr Glu Thr Leu Arg Gln Ile Asp Val His Ile 
        35                  40                  45              


Phe Asn Ala Val Ser Leu Arg Trp Thr Lys Leu Pro Pro Val Lys Ser 
    50                  55                  60                  


Ala Ile Arg Gly Gln Ala Pro Val Val Pro Tyr Met Arg Tyr Gly His 
65                  70                  75                  80  


Ser Thr Val Leu Ile Asp Asp Thr Val Leu Leu Trp Gly Gly Arg Asn 
                85                  90                  95      


Asp Thr Glu Gly Ala Cys Asn Val Leu Tyr Ala Phe Asp Val Asn Thr 
            100                 105                 110         


His Lys Trp Phe Thr Pro Arg Val Ser Gly Thr Val Pro Gly Ala Arg 
        115                 120                 125             


Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile Met Tyr Ile Phe Gly 
    130                 135                 140                 


Gly Tyr Glu Gln Gln Ala Asp Cys Phe Ser Asn Asp Ile His Lys Leu 
145                 150                 155                 160 


Asp Thr Ser Thr Met Thr Trp Thr Leu Ile Cys Thr Lys Gly Ser Pro 
                165                 170                 175     


Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met Leu Gly Ser His Met 
            180                 185                 190         


Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly Pro Phe His Ser Asn 
        195                 200                 205             


Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe Asp Thr Arg Thr Glu 
    210                 215                 220                 


Ala Trp Leu Asp Cys Pro Pro Thr Pro Val Leu Pro Glu Gly Arg Arg 
225                 230                 235                 240 


Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu Tyr Ile Phe Gly Gly 
                245                 250                 255     


Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp Leu Trp Lys Phe Asn 
            260                 265                 270         


Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro Lys Gly Lys Gly Pro 
        275                 280                 285             


Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val Gly Asp Lys Ile Val 
    290                 295                 300                 


Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu Gly Leu Gly Asp Glu 
305                 310                 315                 320 


Phe Asp Leu Ile Asp His Ser Asp Leu His Ile Leu Asp Phe Ser Pro 
                325                 330                 335     


Ser Leu Lys Thr Leu Cys Lys Leu Ala Val Ile Gln Tyr Asn Leu Asp 
            340                 345                 350         


Gln Ser Cys Leu Pro His Asp Ile Arg Trp Glu Leu Asn Ala Met Thr 
        355                 360                 365             


Thr Asn Ser Asn Ile Ser Arg Pro Ile Val Ser Ser His Gly 
    370                 375                 380         


<210> 7649
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7649
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7650
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7650
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7651
<211> 362
<212> PRT
<213> Homo sapiens

<400> 7651
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Phe Thr Glu Ile Ser His Arg Ile Leu Cys Ser Tyr 
225                 230                 235                 240 


Asn Thr Asn Ile Glu Glu Leu Phe Ala Glu Ile Asp Gln Cys Leu Ala 
                245                 250                 255     


Ile Asn Arg Ser Val Leu Gln Gln Leu Glu Glu Lys Cys Gly His Glu 
            260                 265                 270         


Ile Thr Glu Glu Glu Trp Glu Lys Ile Gln Val Gln Ala Leu Arg Arg 
        275                 280                 285             


Glu Thr His Glu Cys Ser Ile Cys Leu Ala Pro Leu Ser Ala Ala Gly 
    290                 295                 300                 


Gly Gln Arg Val Gly Ala Gly Arg Arg Ser Arg Glu Met Ala Leu Leu 
305                 310                 315                 320 


Ser Cys Ser His Val Phe His His Ala Cys Leu Leu Ala Leu Glu Glu 
                325                 330                 335     


Phe Ser Val Gly Asp Arg Pro Pro Phe His Ala Cys Pro Leu Cys Arg 
            340                 345                 350         


Ser Cys Tyr Gln Lys Lys Ile Leu Glu Cys 
        355                 360         


<210> 7652
<211> 421
<212> PRT
<213> Homo sapiens

<400> 7652
Met Ser Ala Leu Arg Arg Ser Gly Tyr Gly Pro Ser Asp Gly Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Tyr Tyr Gly Pro Gly Gly Gly Asp Val Pro Val His Pro 
            20                  25                  30          


Pro Pro Pro Leu Tyr Pro Leu Arg Pro Glu Pro Pro Gln Pro Pro Ile 
        35                  40                  45              


Ser Trp Arg Val Arg Gly Gly Gly Pro Ala Glu Thr Thr Trp Leu Gly 
    50                  55                  60                  


Glu Gly Gly Gly Gly Asp Gly Tyr Tyr Pro Ser Gly Gly Ala Trp Pro 
65                  70                  75                  80  


Glu Pro Gly Arg Ala Gly Gly Ser His Gln Ser Leu Asn Ser Tyr Thr 
                85                  90                  95      


Asn Gly Ala Tyr Gly Pro Thr Tyr Pro Pro Gly Pro Gly Ala Asn Thr 
            100                 105                 110         


Ala Ser Tyr Ser Gly Ala Tyr Tyr Ala Pro Gly Tyr Thr Gln Thr Ser 
        115                 120                 125             


Tyr Ser Thr Glu Val Pro Ser Thr Tyr Arg Ser Ser Gly Asn Ser Pro 
    130                 135                 140                 


Thr Pro Val Ser Arg Trp Ile Tyr Pro Gln Gln Asp Cys Gln Thr Glu 
145                 150                 155                 160 


Ala Pro Pro Leu Arg Gly Gln Val Pro Gly Tyr Pro Pro Ser Gln Asn 
                165                 170                 175     


Pro Gly Met Thr Leu Pro His Tyr Pro Tyr Gly Asp Gly Asn Arg Ser 
            180                 185                 190         


Val Pro Gln Ser Gly Pro Thr Val Arg Pro Gln Glu Asp Ala Trp Ala 
        195                 200                 205             


Ser Pro Gly Ala Tyr Gly Met Gly Gly Arg Tyr Pro Trp Pro Ser Ser 
    210                 215                 220                 


Ala Pro Ser Ala Pro Pro Gly Asn Leu Tyr Met Thr Glu Ser Thr Ser 
225                 230                 235                 240 


Pro Trp Pro Ser Ser Gly Ser Pro Gln Ser Pro Pro Ser Pro Pro Val 
                245                 250                 255     


Gln Gln Pro Lys Asp Ser Ser Tyr Pro Tyr Ser Gln Ser Asp Gln Ser 
            260                 265                 270         


Met Asn Arg His Asn Phe Pro Cys Ser Val His Gln Tyr Glu Ser Ser 
        275                 280                 285             


Gly Thr Val Asn Asn Asp Asp Ser Asp Leu Leu Asp Ser Gln Val Gln 
    290                 295                 300                 


Tyr Ser Ala Glu Pro Gln Leu Tyr Gly Asn Ala Thr Ser Asp His Pro 
305                 310                 315                 320 


Asn Asn Gln Asp Gln Ser Ser Ser Leu Pro Glu Glu Cys Val Pro Ser 
                325                 330                 335     


Asp Glu Ser Thr Pro Pro Ser Ile Lys Lys Ile Ile His Val Leu Glu 
            340                 345                 350         


Lys Val Gln Tyr Leu Glu Gln Glu Val Glu Glu Phe Val Gly Lys Lys 
        355                 360                 365             


Thr Asp Lys Ala Tyr Trp Leu Leu Glu Glu Met Leu Thr Lys Glu Leu 
    370                 375                 380                 


Leu Glu Leu Asp Ser Val Glu Thr Gly Gly Gln Asp Ser Val Arg Gln 
385                 390                 395                 400 


Ala Arg Lys Glu Ala Val Cys Lys Ile Gln Ala Ile Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Lys Gly Leu 
            420     


<210> 7653
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7653
Xaa Asn Leu Arg Glu Gly Ala Glu Gln Lys Val Val Phe Ile Thr Gly 
1               5                   10                  15      


Arg Val His Pro Gly Glu Thr Pro Ser Ser Phe Val Cys Gln Gly Ile 
            20                  25                  30          


Ile Asp Phe Leu Val Ser Gln His Pro Ile Ala Cys Val Leu Arg Glu 
        35                  40                  45              


Tyr Leu Val Phe Lys Ile Ala Pro Met Leu Asn Pro Asp Gly Val Tyr 
    50                  55                  60                  


Leu Gly Asn Tyr Arg Cys Leu Ser Leu Met Arg Asn Gly Ser Arg Gly 
65                  70                  75                  80  


Arg Pro Phe Phe Pro Ser Ser Ser Ala Arg Met Leu Arg Thr Ser Pro 
                85                  90                  95      


Ile Pro Ala His Pro Leu Thr Gly Thr Leu 
            100                 105     


<210> 7654
<211> 227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7654
Xaa Leu Ile Phe Ala Cys Leu Val Pro Gly Phe Pro Ala Val Met Ser 
1               5                   10                  15      


Ser Arg Gly Pro Cys Thr Leu Glu Thr Leu Ile Asn Pro Ser Pro Ser 
            20                  25                  30          


Val Ala Asp Val Lys Ile Tyr Pro Glu Glu Ile Thr Pro Leu Leu Pro 
        35                  40                  45              


Ala Ile Ser Gly Glu Lys Ile Ala Glu Asp Gln Thr Cys Phe Phe Leu 
    50                  55                  60                  


Gln Ile Leu Leu Lys Tyr Met Val Ile Gln Ala Ala Ser Leu Glu Trp 
65                  70                  75                  80  


Lys Asn Lys Glu Asn Gln Asp Thr Gly Phe Lys Phe Leu Phe Thr Leu 
                85                  90                  95      


Phe Arg Lys Tyr Tyr Leu Pro His Leu Phe Pro Ser Phe Thr Lys Leu 
            100                 105                 110         


Thr Asn Ile Tyr Lys Pro Val Leu Asp Ile Pro His Leu Arg Pro Lys 
        115                 120                 125             


Pro Val Tyr Ile Thr Thr Thr Arg Asp Asn Glu Asn Ile Tyr Ser Thr 
    130                 135                 140                 


Lys Ile Pro Tyr Met Ala Ala Arg Val Val Phe Ile Lys Trp Ile Val 
145                 150                 155                 160 


Thr Phe Phe Leu Glu Lys Lys Tyr Leu Thr Ala Thr Gln Asn Thr Lys 
                165                 170                 175     


Asn Gly Val Asp Val Leu Pro Lys Ile Ile Gln Thr Val Gly Gly Gly 
            180                 185                 190         


Ala Val Gln Glu Arg Ala Pro Glu Leu Asp Gly Gly Gly Pro Thr Glu 
        195                 200                 205             


Gln Asp Lys Ser His Ser Asn Ser Ser Thr Leu Ser Asp Arg Arg Leu 
    210                 215                 220                 


Ser Asn Ser 
225         


<210> 7655
<211> 190
<212> PRT
<213> Homo sapiens

<400> 7655
Met Glu Pro Pro Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly Ala 
1               5                   10                  15      


Val Arg Phe Leu Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His Val 
            20                  25                  30          


Leu Asn Arg Val Pro Leu Arg Gln Leu Leu Arg Leu Gln Arg Val Ser 
        35                  40                  45              


Arg Ala Phe Arg Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg Arg 
    50                  55                  60                  


Phe Asp Ala Ala Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu Ala 
65                  70                  75                  80  


Arg Leu Leu Arg Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala Pro 
                85                  90                  95      


Cys His Glu Trp Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala Arg 
            100                 105                 110         


Asn Pro Gln Leu Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu Ser 
        115                 120                 125             


Arg Arg Ala Leu Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln Arg 
    130                 135                 140                 


Leu Ser Leu Ala His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg Gly 
145                 150                 155                 160 


Leu Ala Asp Arg Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala Cys 
                165                 170                 175     


Arg Gln Leu Lys Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg 
            180                 185                 190 


<210> 7656
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7656
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 7657
<211> 126
<212> PRT
<213> Homo sapiens

<400> 7657
Met Thr Thr Arg Ser Val Leu Asp Val Glu Thr Phe Val Ala Asp Ile 
1               5                   10                  15      


Leu Lys Gly Glu Asn Leu Ser Lys Lys Ala Lys Glu Lys Arg Glu Ser 
            20                  25                  30          


Leu Ile Lys Lys Ile Lys Asp Val Lys Ser Ile Tyr Leu Gln Glu Phe 
        35                  40                  45              


Gln Asp Lys Gly Asp Ala Glu Asp Gly Glu Glu Tyr Asp Asp Pro Phe 
    50                  55                  60                  


Ala Gly Pro Pro Asp Thr Ile Ser Leu Ala Ser Glu Arg Tyr Asp Lys 
65                  70                  75                  80  


Asp Asp Glu Ala Pro Ser Asp Gly Ala Gln Phe Pro Pro Ile Ala Ala 
                85                  90                  95      


Gln Asp Leu Pro Phe Val Leu Lys Ala Gly Tyr Leu Glu Lys Arg Arg 
            100                 105                 110         


Lys Asp His Ser Phe Leu Gly Phe Glu Trp Gln Lys Arg Trp 
        115                 120                 125     


<210> 7658
<211> 225
<212> PRT
<213> Homo sapiens

<400> 7658
Met Leu Ser Ala Val Ala Arg Gly Tyr Gln Gly Trp Phe His Pro Cys 
1               5                   10                  15      


Ala Arg Leu Ser Val Arg Met Ser Ser Thr Gly Ile Asp Arg Lys Gly 
            20                  25                  30          


Val Leu Ala Asn Arg Val Ala Val Val Thr Gly Ser Thr Ser Gly Ile 
        35                  40                  45              


Gly Phe Ala Ile Ala Arg Arg Leu Ala Arg Asp Gly Ala His Val Val 
    50                  55                  60                  


Ile Ser Ser Arg Lys Gln Gln Asn Val Asp Arg Ala Met Ala Lys Leu 
65                  70                  75                  80  


Gln Gly Glu Gly Leu Ser Val Ala Gly Ile Val Cys His Val Gly Lys 
                85                  90                  95      


Ala Glu Asp Arg Glu Gln Leu Val Ala Lys Ala Leu Glu His Cys Gly 
            100                 105                 110         


Gly Val Asp Phe Leu Val Cys Ser Ala Gly Val Asn Pro Leu Val Gly 
        115                 120                 125             


Ser Thr Leu Gly Thr Ser Glu Gln Ile Trp Asp Lys Ile Leu Ser Val 
    130                 135                 140                 


Asn Val Lys Ser Pro Ala Leu Leu Leu Ser Gln Leu Leu Pro Tyr Met 
145                 150                 155                 160 


Glu Asn Arg Arg Gly Ala Val Ile Leu Val Ser Ser Ile Ala Ala Tyr 
                165                 170                 175     


Asn Pro Val Val Ala Leu Gly Val Tyr Asn Val Ser Lys Thr Ala Leu 
            180                 185                 190         


Leu Gly Leu Thr Arg Thr Leu Ala Leu Glu Leu Ala Pro Lys Asp Ile 
        195                 200                 205             


Arg Val Asn Cys Val Val Pro Gly Ile Ile Lys Thr Asp Phe Ser Lys 
    210                 215                 220                 


Val 
225 


<210> 7659
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7659
Xaa Ala Thr Ala Met Thr Ser Ala Trp Leu Ala Gln Gly Thr Gly Glu 
1               5                   10                  15      


Gly Val Asn Asp Val Arg Lys Gly Ala Cys Ala Ser His Val Ser Thr 
            20                  25                  30          


Met Ala Ser Phe Leu Lys Gly Ala His Val Thr Ile Asn Ala Arg Ala 
        35                  40                  45              


Glu Glu Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala 
    50                  55                  60                  


Ser Gly Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp 
65                  70                  75                  80  


Val Gly Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Thr Asn Ala 
                85                  90                  95      


Val Ser Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala 
            100                 105                 110         


Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu 
        115                 120                 125             


Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg 
    130                 135                 140                 


Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Arg Thr Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn 
                165                 170                 175     


Arg Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
            180                 185                 190         


Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly 
        195                 200                 205             


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr 
    210                 215                 220                 


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
225                 230                 235                 240 


Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln 
                245                 250                 255     


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe 
            260                 265                 270         


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
        275                 280                 285             


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
    290                 295                 300                 


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser 
305                 310                 315                 320 


Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly 
                325                 330                 335     


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
            340                 345                 350         


Asn Tyr Val Glu Leu Ile Glu 
        355                 


<210> 7660
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7660
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7661
<211> 871
<212> PRT
<213> Homo sapiens

<400> 7661
Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe 
1               5                   10                  15      


Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg 
            20                  25                  30          


Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu 
        35                  40                  45              


Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu 
    50                  55                  60                  


Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met 
65                  70                  75                  80  


Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr 
                85                  90                  95      


Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro 
            100                 105                 110         


Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu 
        115                 120                 125             


Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val 
    130                 135                 140                 


Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp 
145                 150                 155                 160 


Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys 
                165                 170                 175     


Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys 
            180                 185                 190         


Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys 
        195                 200                 205             


Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe 
    210                 215                 220                 


Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile 
225                 230                 235                 240 


Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys 
                245                 250                 255     


Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu 
            260                 265                 270         


Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu 
        275                 280                 285             


Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp 
    290                 295                 300                 


Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser 
305                 310                 315                 320 


Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu 
                325                 330                 335     


Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg 
            340                 345                 350         


Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser 
        355                 360                 365             


Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu 
    370                 375                 380                 


Glu Ala Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu Trp 
385                 390                 395                 400 


Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro Leu 
                405                 410                 415     


His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile Ser 
            420                 425                 430         


Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met Arg 
        435                 440                 445             


Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg Gly 
    450                 455                 460                 


Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp Asn 
465                 470                 475                 480 


Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val Asn 
                485                 490                 495     


Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln His 
            500                 505                 510         


Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile His 
        515                 520                 525             


Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr Pro 
    530                 535                 540                 


Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn Ile 
545                 550                 555                 560 


Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu Leu 
                565                 570                 575     


Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly Asn 
            580                 585                 590         


Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val Leu 
        595                 600                 605             


Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr Tyr 
    610                 615                 620                 


Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys Gly 
625                 630                 635                 640 


Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His Gly 
                645                 650                 655     


Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro Leu 
            660                 665                 670         


Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met Gly 
        675                 680                 685             


Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn Thr 
    690                 695                 700                 


Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys Lys 
705                 710                 715                 720 


Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His Ala 
                725                 730                 735     


Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn Phe 
            740                 745                 750         


Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala Gln 
        755                 760                 765             


Pro Pro Gly Pro Ala Gln Ser Leu Thr Pro Gly Leu Pro Tyr Pro His 
    770                 775                 780                 


Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln Pro Arg Pro Pro Ile 
785                 790                 795                 800 


Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val Pro Thr Gly Gly 
                805                 810                 815     


Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg Gly Asn Tyr Asp 
            820                 825                 830         


Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys Pro Arg Asn Arg Met 
        835                 840                 845             


Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr Arg Asp Leu Asp Ala 
    850                 855                 860                 


Pro Asp Asp Val Asp Phe Phe 
865                 870     


<210> 7662
<211> 674
<212> PRT
<213> Homo sapiens

<400> 7662
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met 
            100                 105                 110         


Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser 
        115                 120                 125             


Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr 
    130                 135                 140                 


Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser 
145                 150                 155                 160 


Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe 
                165                 170                 175     


Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met 
            180                 185                 190         


Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly 
        195                 200                 205             


Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val 
    210                 215                 220                 


Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val 
225                 230                 235                 240 


Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln 
                245                 250                 255     


Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro 
            260                 265                 270         


Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu 
        275                 280                 285             


Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val 
    290                 295                 300                 


Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser 
305                 310                 315                 320 


Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile 
                325                 330                 335     


Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln 
            340                 345                 350         


Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro 
        355                 360                 365             


Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile 
    370                 375                 380                 


Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp 
385                 390                 395                 400 


Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile 
                405                 410                 415     


Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly 
            420                 425                 430         


Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser 
    450                 455                 460                 


Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys 
465                 470                 475                 480 


Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val 
                485                 490                 495     


Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly 
            500                 505                 510         


Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu 
        515                 520                 525             


Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala 
    530                 535                 540                 


Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val 
545                 550                 555                 560 


Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile 
                565                 570                 575     


Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu 
            580                 585                 590         


Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met 
        595                 600                 605             


Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln 
    610                 615                 620                 


Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala 
625                 630                 635                 640 


Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser 
                645                 650                 655     


Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys 
            660                 665                 670         


Gly Lys 
        


<210> 7663
<211> 488
<212> PRT
<213> Homo sapiens

<400> 7663
Met Ser Asp Glu Val Phe Ser Thr Thr Leu Ala Tyr Thr Lys Ser Pro 
1               5                   10                  15      


Lys Val Thr Lys Arg Thr Thr Phe Gln Asp Glu Leu Ile Arg Ala Ile 
            20                  25                  30          


Thr Ala Arg Ser Ala Arg Gln Arg Ser Ser Glu Tyr Ser Asp Asp Phe 
        35                  40                  45              


Asp Ser Asp Glu Ile Val Ser Leu Gly Asp Phe Ser Asp Thr Ser Ala 
    50                  55                  60                  


Asp Glu Asn Ser Val Asn Lys Lys Met Asn Asp Phe His Ile Ser Asp 
65                  70                  75                  80  


Asp Glu Glu Lys Asn Pro Ser Lys Leu Leu Phe Leu Lys Thr Asn Lys 
                85                  90                  95      


Ser Asn Gly Asn Ile Thr Lys Asp Glu Pro Val Cys Ala Ile Lys Asn 
            100                 105                 110         


Glu Glu Glu Met Ala Pro Asp Gly Cys Glu Asp Ile Val Val Lys Ser 
        115                 120                 125             


Phe Ser Glu Ser Gln Asn Lys Asp Glu Glu Phe Glu Lys Asp Lys Ile 
    130                 135                 140                 


Lys Met Lys Pro Lys Pro Arg Ile Leu Ser Ile Lys Ser Thr Ser Ser 
145                 150                 155                 160 


Glu Asn Asn Ser Leu Asp Thr Asp Asp His Phe Lys Pro Ser Pro Arg 
                165                 170                 175     


Pro Arg Ser Met Leu Lys Lys Lys Ser His Met Glu Glu Lys Asp Gly 
            180                 185                 190         


Leu Glu Asp Lys Glu Thr Ala Leu Ser Glu Glu Leu Glu Leu His Ser 
        195                 200                 205             


Ala Pro Ser Ser Leu Pro Thr Pro Asn Gly Ile Gln Leu Glu Ala Glu 
    210                 215                 220                 


Lys Lys Ala Phe Ser Glu Asn Leu Asp Pro Glu Asp Ser Cys Leu Thr 
225                 230                 235                 240 


Ser Leu Ala Ser Ser Ser Leu Lys Gln Ile Leu Gly Asp Ser Phe Ser 
                245                 250                 255     


Pro Gly Ser Glu Gly Asn Ala Ser Gly Lys Asp Pro Asn Glu Glu Ile 
            260                 265                 270         


Thr Glu Asn His Asn Ser Leu Lys Ser Asp Glu Asn Lys Glu Asn Ser 
        275                 280                 285             


Phe Ser Ala Asp His Val Thr Thr Ala Val Glu Lys Ser Lys Glu Ser 
    290                 295                 300                 


Gln Val Thr Ala Asp Asp Leu Glu Glu Glu Lys Ala Lys Ala Glu Leu 
305                 310                 315                 320 


Ile Met Asp Asp Asp Arg Thr Val Asp Pro Leu Leu Ser Lys Ser Gln 
                325                 330                 335     


Ser Ile Leu Ile Ser Thr Ser Ala Thr Ala Ser Ser Lys Lys Thr Ile 
            340                 345                 350         


Glu Asp Arg Asn Ile Lys Asn Lys Lys Ser Thr Asn Asn Arg Ala Ser 
        355                 360                 365             


Ser Ala Ser Ala Arg Leu Met Thr Ser Glu Phe Leu Lys Lys Ser Ser 
    370                 375                 380                 


Ser Lys Arg Arg Thr Pro Ser Thr Thr Thr Ser Ser His Tyr Leu Gly 
385                 390                 395                 400 


Thr Leu Lys Val Leu Asp Gln Lys Pro Ser Gln Lys Gln Ser Ile Glu 
                405                 410                 415     


Pro Asp Arg Ala Asp Asn Ile Arg Ala Ala Val Tyr Gln Glu Trp Leu 
            420                 425                 430         


Glu Lys Lys Asn Val Tyr Leu His Glu Met His Arg Ile Lys Arg Ile 
        435                 440                 445             


Glu Ser Glu Asn Leu Arg Ile Gln Asn Glu Gln Lys Lys Ala Ala Lys 
    450                 455                 460                 


Arg Glu Glu Ala Leu Ala Ser Phe Glu Ala Trp Lys Ala Met Lys Glu 
465                 470                 475                 480 


Lys Glu Ala Lys Lys Ile Ala Ala 
                485             


<210> 7664
<211> 187
<212> PRT
<213> Homo sapiens

<400> 7664
Met Val Arg Glu Pro Gly Pro Arg Pro Gly Thr Pro Gly Cys Ser Ala 
1               5                   10                  15      


Ser Gly Gln Trp Thr Ala Thr Leu Arg Pro Tyr Leu Ser Ala Val Arg 
            20                  25                  30          


Ala Thr Leu Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val 
        35                  40                  45              


Val Glu Arg His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu 
    50                  55                  60                  


Leu Leu Leu Gln Pro Val Thr Ile Ser Arg Asn Glu Lys Glu Lys Val 
65                  70                  75                  80  


Leu Ile Glu Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys 
                85                  90                  95      


Gln Ala Asp Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe 
            100                 105                 110         


Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val 
        115                 120                 125             


Glu Gly Tyr Asp Ile Ser Phe Leu Ile Thr Asn Phe His Thr Glu Gln 
    130                 135                 140                 


Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu 
145                 150                 155                 160 


Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala 
                165                 170                 175     


Arg Ile Val Ala Glu Glu Phe Leu Lys Asn Phe 
            180                 185         


<210> 7665
<211> 355
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7665
Xaa Ser Leu Ala Ser Ser Leu Arg Asn Lys Glu Gly Thr Leu Gly Ser 
1               5                   10                  15      


Lys Val Gly Tyr Leu Asp Val Glu Ala Arg Gly Pro Gly Glu Gly Arg 
            20                  25                  30          


Gly Gly Gly Gly Glu Ser Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro 
        35                  40                  45              


Val Leu Leu Tyr Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala 
    50                  55                  60                  


Glu Ala Glu Ala Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu 
65                  70                  75                  80  


Leu Gln Lys Leu Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly 
                85                  90                  95      


Gly Phe Ser Arg Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser 
            100                 105                 110         


Leu Ala Gly Arg Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val 
        115                 120                 125             


Pro Val Val Gly Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp 
    130                 135                 140                 


Ala Glu Ser Glu Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser 
145                 150                 155                 160 


Glu Gly Ala Thr Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val 
                165                 170                 175     


Gln Ile Leu Pro Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn 
            180                 185                 190         


Leu Glu Ser Leu Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr 
        195                 200                 205             


Pro Asn Leu Pro Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys 
    210                 215                 220                 


Gln Ile Pro Ile Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe 
225                 230                 235                 240 


Pro Glu Ala Ile Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly 
                245                 250                 255     


Val Leu Val His Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr 
            260                 265                 270         


Val Ala Tyr Leu Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr 
        275                 280                 285             


Asp Leu Val Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe 
    290                 295                 300                 


Met Gly Gln Leu Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg 
305                 310                 315                 320 


His Ser Gln Glu Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn 
                325                 330                 335     


Pro Pro Ser Phe Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu 
            340                 345                 350         


Ala Pro Thr 
        355 


<210> 7666
<211> 16
<212> PRT
<213> Homo sapiens

<400> 7666
Met Cys Thr Ser Glu Thr Phe Gln Ala Leu Asp Thr Phe Glu Ala Arg 
1               5                   10                  15      


<210> 7667
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7667
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7668
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7668
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 7669
<211> 850
<212> PRT
<213> Homo sapiens

<400> 7669
Met Glu Pro Glu Arg Lys Gly Leu Ser Leu Ala Ser Ser Ser Asp Gly 
1               5                   10                  15      


Asp Gly Arg Glu Glu Asn Lys Leu Lys Gln Gly Ile Ser Gln Asp Leu 
            20                  25                  30          


Ala Ser Ser Ser Arg Leu Asp Arg Tyr Lys Ile Ala Arg Gln Leu Thr 
        35                  40                  45              


Glu Lys Ala Ile Lys Glu Lys Lys Ile Phe Ser Ile Tyr Gly His Tyr 
    50                  55                  60                  


Pro Val Val Arg Ala Ala Leu Arg Arg Lys Gly Trp Val Glu Lys Lys 
65                  70                  75                  80  


Phe His Phe Leu Pro Lys Val Ile Pro Asp Val Glu Asp Glu Gly Ala 
                85                  90                  95      


Arg Val Asn Asp Asp Thr Cys Ala Lys Val Lys Glu Asn Gln Glu Met 
            100                 105                 110         


Ala Leu Glu Lys Thr Asp Asn Ile His Asp Val Met Ser Arg Leu Val 
        115                 120                 125             


Lys Asn Glu Met Pro Tyr Leu Leu Trp Thr Ile Lys Arg Asp Ile Ile 
    130                 135                 140                 


Asp Tyr His Ser Leu Thr Tyr Asp Gln Met Leu Asn His Tyr Ala Lys 
145                 150                 155                 160 


Thr Ala Ser Phe Thr Thr Lys Ile Gly Leu Cys Val Asn Met Arg Ser 
                165                 170                 175     


Leu Pro Trp Tyr Val Pro Ala Asn Pro Asp Ser Phe Phe Pro Arg Cys 
            180                 185                 190         


Tyr Ser Leu Cys Thr Glu Ser Glu Gln Gln Glu Phe Leu Glu Asp Phe 
        195                 200                 205             


Arg Arg Thr Met Ala Ser Ser Ile Leu Lys Trp Val Val Ser His Gln 
    210                 215                 220                 


Ser Cys Ser Arg Ser Ser Arg Ser Lys Pro Arg Asp Gln Arg Glu Glu 
225                 230                 235                 240 


Ala Gly Ser Ser Asp Leu Ser Ser Arg Gln Asp Ala Glu Asn Ala Glu 
                245                 250                 255     


Ala Lys Leu Arg Gly Leu Pro Gly Gln Leu Val Asp Ile Ala Cys Lys 
            260                 265                 270         


Val Cys Gln Ala Tyr Leu Gly Gln Leu Glu His Glu Asp Ile Asp Thr 
        275                 280                 285             


Ser Ala Asp Ala Val Glu Asp Leu Thr Glu Ala Glu Trp Glu Asp Leu 
    290                 295                 300                 


Thr Gln Gln Tyr Tyr Ser Leu Val His Gly Asp Ala Phe Ile Ser Asn 
305                 310                 315                 320 


Ser Arg Asn Tyr Phe Ser Gln Cys Gln Ala Leu Leu Asn Arg Ile Thr 
                325                 330                 335     


Ser Val Asn Pro Gln Thr Asp Ile Asp Gly Leu Arg Asn Ile Trp Ile 
            340                 345                 350         


Ile Lys Pro Ala Ala Lys Ser Arg Gly Arg Asp Ile Val Cys Met Asp 
        355                 360                 365             


Arg Val Glu Glu Ile Leu Glu Leu Ala Ala Ala Asp His Pro Leu Ser 
    370                 375                 380                 


Arg Asp Asn Lys Trp Val Val Gln Lys Tyr Ile Glu Thr Pro Leu Leu 
385                 390                 395                 400 


Ile Cys Asp Thr Lys Phe Asp Ile Arg Gln Trp Phe Leu Val Thr Asp 
                405                 410                 415     


Trp Asn Pro Leu Thr Ile Trp Phe Tyr Lys Glu Ser Tyr Leu Arg Phe 
            420                 425                 430         


Ser Thr Gln Arg Phe Ser Leu Asp Lys Leu Asp Ser Ala Ile His Leu 
        435                 440                 445             


Cys Asn Asn Ala Val Gln Lys Tyr Leu Lys Asn Asp Val Gly Arg Ser 
    450                 455                 460                 


Pro Leu Leu Pro Ala His Asn Met Trp Thr Ser Thr Arg Phe Gln Glu 
465                 470                 475                 480 


Tyr Leu Gln Arg Gln Gly Arg Gly Ala Val Trp Gly Ser Val Ile Tyr 
                485                 490                 495     


Pro Ser Met Lys Lys Ala Ile Ala His Ala Met Lys Val Ala Gln Asp 
            500                 505                 510         


His Val Glu Pro Arg Lys Asn Ser Phe Glu Leu Tyr Gly Ala Asp Phe 
        515                 520                 525             


Val Leu Gly Arg Asp Phe Arg Pro Trp Leu Ile Glu Ile Asn Ser Ser 
    530                 535                 540                 


Pro Thr Met His Pro Ser Thr Pro Val Thr Ala Gln Leu Cys Ala Gln 
545                 550                 555                 560 


Val Gln Glu Asp Thr Ile Lys Val Ala Val Asp Arg Ser Cys Asp Ile 
                565                 570                 575     


Gly Asn Phe Glu Leu Leu Trp Arg Gln Pro Val Val Glu Pro Pro Pro 
            580                 585                 590         


Phe Ser Gly Ser Asp Leu Cys Val Ala Gly Val Ser Val Arg Arg Ala 
        595                 600                 605             


Arg Arg Gln Val Leu Pro Val Cys Asn Leu Lys Ala Ser Ala Ser Leu 
    610                 615                 620                 


Leu Asp Ala Gln Pro Leu Lys Ala Arg Gly Pro Ser Ala Met Pro Asp 
625                 630                 635                 640 


Pro Ala Gln Gly Pro Pro Ser Pro Ala Leu Gln Arg Asp Leu Gly Leu 
                645                 650                 655     


Lys Glu Glu Lys Gly Leu Pro Leu Ala Leu Leu Ala Pro Leu Arg Gly 
            660                 665                 670         


Ala Ala Glu Ser Gly Gly Ala Ala Gln Pro Thr Arg Thr Lys Ala Ala 
        675                 680                 685             


Gly Lys Val Glu Leu Pro Ala Cys Pro Cys Arg His Val Asp Ser Gln 
    690                 695                 700                 


Ala Pro Asn Thr Gly Val Pro Val Ala Gln Pro Ala Lys Ser Trp Asp 
705                 710                 715                 720 


Pro Asn Gln Leu Asn Ala His Pro Leu Glu Pro Val Leu Arg Gly Leu 
                725                 730                 735     


Lys Thr Ala Glu Gly Ala Leu Arg Pro Pro Pro Gly Gly Lys Gly Glu 
            740                 745                 750         


Gly Thr Val Cys Ser Arg Leu Pro His His Gly His His Val Ala Ala 
        755                 760                 765             


Cys Gln Thr Thr Gly Thr Thr Trp Asp Gly Gly Pro Gly Val Cys Phe 
    770                 775                 780                 


Leu Arg Gln Leu Leu Ala Ser Glu Leu Pro Met Gly Pro Gly Leu Pro 
785                 790                 795                 800 


Arg Asp Pro Arg Ala Pro Pro Cys Leu Val Cys Arg Gly Leu Leu Pro 
                805                 810                 815     


Pro Ala Gly Pro Cys Lys Arg Cys Arg Ser Phe Cys Ala Ala Val Leu 
            820                 825                 830         


Gln Gly Ala Ser Phe Val Arg Leu Gly Gly Arg Ser Cys Ser Pro Arg 
        835                 840                 845             


Thr Pro 
    850 


<210> 7670
<211> 912
<212> PRT
<213> Homo sapiens

<400> 7670
Met Lys Arg Gly Ile Arg Arg Asp Pro Phe Arg Lys Arg Lys Leu Gly 
1               5                   10                  15      


Gly Arg Ala Lys Lys Val Arg Glu Pro Thr Ala Val Asn Ser Phe Tyr 
            20                  25                  30          


Arg Glu Ala Ser Leu Pro Ser Val Trp Ala Ser Leu Arg Arg Arg Glu 
        35                  40                  45              


Met Val Arg Ser Gly Ala Arg Pro Gly Gln Val Leu Ser Ser Gly Arg 
    50                  55                  60                  


His Thr Gly Pro Ala Lys Leu Thr Asn Gly Lys Lys Ala Thr Tyr Leu 
65                  70                  75                  80  


Arg Lys Ile Pro Arg Phe Asn Ala Asp Ser Gly Tyr Ser Ile His Ser 
                85                  90                  95      


Asp Ser Glu Ser Gln Ala Glu Thr Val His Gly Leu Asp Gly Cys Ala 
            100                 105                 110         


Ser Leu Leu Arg Asp Ile Leu Arg Asn Glu Asp Ser Ala Ser Ser Asp 
        115                 120                 125             


Asn Lys Lys Gln Ile Pro Asn Glu Ala Ser Ala Arg Ser Glu Arg Asp 
    130                 135                 140                 


Thr Ser Asp Leu Glu Gln Asn Trp Ser Leu Gln Asp His Tyr Arg Met 
145                 150                 155                 160 


Tyr Ser Pro Ile Ile Tyr Gln Ala Leu Cys Glu His Val Gln Thr Gln 
                165                 170                 175     


Met Ser Leu Met Asn Asp Leu Thr Ser Lys Asn Ile Pro Asn Gly Ile 
            180                 185                 190         


Pro Ala Val Pro Cys His Ala Pro Ser His Ser Glu Ser Gln Ala Thr 
        195                 200                 205             


Pro His Ser Ser Tyr Gly Leu Cys Thr Ser Thr Pro Val Trp Ser Leu 
    210                 215                 220                 


Gln Arg Pro Pro Cys Pro Pro Lys Val His Ser Glu Val Gln Thr Asp 
225                 230                 235                 240 


Gly Asn Ser Gln Phe Ala Ser Gln Gly Lys Thr Val Ser Ala Thr Cys 
                245                 250                 255     


Thr Asp Val Leu Arg Asn Ser Phe Asn Thr Ser Pro Gly Val Pro Cys 
            260                 265                 270         


Ser Leu Pro Lys Thr Asp Ile Ser Ala Ile Pro Thr Leu Gln Gln Leu 
        275                 280                 285             


Gly Leu Val Asn Gly Ile Leu Pro Gln Gln Gly Ile His Lys Glu Thr 
    290                 295                 300                 


Asp Leu Leu Lys Cys Ile Gln Thr Tyr Leu Ser Leu Phe Arg Ser His 
305                 310                 315                 320 


Gly Lys Glu Thr His Leu Asp Ser Gln Thr His Arg Ser Pro Thr Gln 
                325                 330                 335     


Ser Gln Pro Ala Phe Leu Ala Thr Asn Glu Glu Lys Cys Ala Arg Glu 
            340                 345                 350         


Gln Ile Arg Glu Ala Thr Ser Glu Arg Lys Asp Leu Asn Ile His Val 
        355                 360                 365             


Arg Asp Thr Lys Thr Val Lys Asp Val Gln Lys Ala Lys Asn Val Asn 
    370                 375                 380                 


Lys Thr Ala Glu Lys Val Arg Ile Ile Lys Tyr Leu Leu Gly Glu Leu 
385                 390                 395                 400 


Lys Ala Leu Val Ala Glu Gln Glu Asp Ser Glu Ile Gln Arg Leu Ile 
                405                 410                 415     


Thr Glu Met Glu Ala Cys Ile Ser Val Leu Pro Thr Val Ser Gly Asn 
            420                 425                 430         


Thr Asp Ile Gln Val Glu Ile Ala Leu Ala Met Gln Pro Leu Arg Ser 
        435                 440                 445             


Glu Asn Ala Gln Leu Arg Arg Gln Leu Arg Ile Leu Asn Gln Gln Leu 
    450                 455                 460                 


Arg Glu Gln Gln Lys Thr Gln Lys Pro Ser Gly Ala Val Asp Cys Asn 
465                 470                 475                 480 


Leu Glu Leu Phe Ser Leu Gln Ser Leu Asn Met Ser Leu Gln Asn Gln 
                485                 490                 495     


Leu Glu Glu Ser Leu Lys Ser Gln Glu Leu Leu Gln Ser Lys Asn Glu 
            500                 505                 510         


Glu Leu Leu Lys Val Ile Glu Asn Gln Lys Asp Glu Asn Lys Lys Phe 
        515                 520                 525             


Ser Ser Ile Phe Lys Asp Lys Asp Gln Thr Ile Leu Glu Asn Lys Gln 
    530                 535                 540                 


Gln Tyr Asp Ile Glu Ile Thr Arg Ile Lys Ile Glu Leu Glu Glu Ala 
545                 550                 555                 560 


Leu Val Asn Val Lys Ser Ser Gln Phe Lys Leu Glu Thr Ala Glu Lys 
                565                 570                 575     


Glu Asn Gln Ile Leu Gly Ile Thr Leu Arg Gln Arg Asp Ala Glu Val 
            580                 585                 590         


Thr Arg Leu Arg Glu Leu Thr Arg Thr Leu Gln Thr Ser Met Ala Lys 
        595                 600                 605             


Leu Leu Ser Asp Leu Ser Val Asp Ser Ala Arg Cys Lys Pro Gly Asn 
    610                 615                 620                 


Asn Leu Thr Lys Ser Leu Leu Asn Ile His Asp Lys Gln Leu Gln His 
625                 630                 635                 640 


Asp Pro Ala Pro Ala His Thr Ser Ile Met Ser Tyr Leu Asn Lys Leu 
                645                 650                 655     


Glu Thr Asn Tyr Ser Phe Thr His Ser Glu Pro Leu Ser Thr Ile Lys 
            660                 665                 670         


Asn Glu Glu Thr Ile Glu Pro Asp Lys Thr Tyr Glu Asn Val Leu Ser 
        675                 680                 685             


Ser Arg Gly Pro Gln Asn Ser Asn Thr Arg Gly Met Glu Glu Ala Ser 
    690                 695                 700                 


Ala Pro Gly Ile Ile Ser Ala Leu Ser Lys Gln Asp Ser Asp Glu Gly 
705                 710                 715                 720 


Ser Glu Thr Met Ala Leu Ile Glu Asp Glu His Asn Leu Asp Asn Thr 
                725                 730                 735     


Ile Tyr Ile Pro Phe Ala Arg Ser Thr Pro Glu Lys Lys Ser Pro Leu 
            740                 745                 750         


Ser Lys Arg Leu Ser Pro Gln Pro Gln Ile Arg Ala Ala Thr Thr Gln 
        755                 760                 765             


Leu Val Ser Asn Ser Gly Leu Ala Val Ser Gly Lys Glu Asn Lys Leu 
    770                 775                 780                 


Cys Thr Pro Val Ile Cys Ser Ser Ser Thr Lys Glu Ala Glu Asp Ala 
785                 790                 795                 800 


Pro Glu Lys Leu Ser Arg Ala Ser Asp Met Lys Asp Thr Gln Leu Leu 
                805                 810                 815     


Lys Lys Ile Lys Glu Ala Ile Gly Lys Ile Pro Ala Ala Thr Lys Glu 
            820                 825                 830         


Pro Glu Glu Gln Thr Ala Cys His Gly Pro Ser Gly Cys Leu Ser Asn 
        835                 840                 845             


Ser Leu Gln Val Lys Gly Asn Thr Val Cys Asp Gly Ser Val Phe Thr 
    850                 855                 860                 


Ser Asp Leu Met Ser Asp Trp Ser Ile Ser Ser Phe Ser Thr Phe Thr 
865                 870                 875                 880 


Ser Arg Asp Glu Gln Asp Phe Arg Asn Gly Leu Ala Ala Leu Asp Ala 
                885                 890                 895     


Asn Ile Ala Arg Leu Gln Lys Ser Leu Arg Thr Gly Leu Leu Glu Lys 
            900                 905                 910         


<210> 7671
<211> 175
<212> PRT
<213> Homo sapiens

<400> 7671
Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Leu Arg 
                85                  90                  95      


Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val Ala Ala Glu Cys Ser 
            100                 105                 110         


Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp Pro Ala Trp His Leu 
        115                 120                 125             


Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser Trp Lys Ala Leu Glu 
    130                 135                 140                 


Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His Ile Gln Ala Pro Leu 
145                 150                 155                 160 


Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly Tyr Ala Val Lys 
                165                 170                 175 


<210> 7672
<211> 463
<212> PRT
<213> Homo sapiens

<400> 7672
Met Ser Gly Gly Thr Pro Tyr Ile Gly Ser Lys Ile Ser Leu Ile Ser 
1               5                   10                  15      


Lys Ala Glu Ile Arg Tyr Glu Gly Ile Leu Tyr Thr Ile Asp Thr Glu 
            20                  25                  30          


Asn Ser Thr Val Ala Leu Ala Lys Val Arg Ser Phe Gly Thr Glu Asp 
        35                  40                  45              


Arg Pro Thr Asp Arg Pro Ile Pro Pro Arg Asp Glu Val Phe Glu Tyr 
    50                  55                  60                  


Ile Ile Phe Arg Gly Ser Asp Ile Lys Asp Leu Thr Val Cys Glu Pro 
65                  70                  75                  80  


Pro Lys Pro Gln Cys Ser Leu Pro Gln Asp Pro Ala Ile Val Gln Ser 
                85                  90                  95      


Ser Leu Gly Ser Ser Thr Ser Ser Phe Gln Ser Met Gly Ser Tyr Gly 
            100                 105                 110         


Pro Phe Gly Arg Met Pro Thr Tyr Ser Gln Phe Ser Pro Ser Ser Leu 
        115                 120                 125             


Val Gly Gln Gln Phe Gly Ala Val Gly Val Ala Gly Ser Ser Leu Thr 
    130                 135                 140                 


Ser Phe Gly Thr Glu Thr Ser Asn Ser Gly Thr Leu Pro Gln Ser Ser 
145                 150                 155                 160 


Ala Val Gly Ser Ala Phe Thr Gln Asp Thr Arg Ser Leu Lys Thr Gln 
                165                 170                 175     


Leu Ser Gln Gly Arg Ser Ser Pro Gln Leu Asp Pro Leu Arg Lys Ser 
            180                 185                 190         


Pro Thr Met Glu Gln Ala Val Gln Thr Ala Ser Ala His Leu Pro Ala 
        195                 200                 205             


Pro Ala Ala Val Gly Arg Arg Ser Pro Val Ser Thr Arg Pro Leu Pro 
    210                 215                 220                 


Ser Ala Ser Gln Lys Ala Gly Glu Asn Gln Glu His Arg Arg Ala Glu 
225                 230                 235                 240 


Val His Lys Val Ser Arg Pro Glu Asn Glu Gln Leu Arg Asn Asp Asn 
                245                 250                 255     


Lys Arg Gln Val Ala Pro Gly Ala Pro Ser Ala Pro Arg Arg Gly Arg 
            260                 265                 270         


Gly Gly His Arg Gly Gly Arg Gly Arg Phe Gly Ile Arg Arg Asp Gly 
        275                 280                 285             


Pro Met Lys Phe Glu Lys Asp Phe Asp Phe Glu Ser Ala Asn Ala Gln 
    290                 295                 300                 


Phe Asn Lys Glu Glu Ile Asp Arg Glu Phe His Asn Lys Leu Lys Leu 
305                 310                 315                 320 


Lys Glu Asp Lys Leu Glu Lys Gln Glu Lys Pro Val Asn Gly Glu Asp 
                325                 330                 335     


Lys Gly Asp Ser Gly Val Asp Thr Gln Asn Ser Glu Gly Asn Ala Asp 
            340                 345                 350         


Glu Glu Asp Pro Leu Gly Pro Asn Cys Tyr Tyr Asp Lys Thr Lys Ser 
        355                 360                 365             


Phe Phe Asp Asn Ile Ser Cys Asp Asp Asn Arg Glu Arg Arg Pro Thr 
    370                 375                 380                 


Trp Ala Glu Glu Arg Arg Leu Asn Ala Glu Thr Phe Gly Ile Pro Leu 
385                 390                 395                 400 


Arg Pro Asn Arg Gly Arg Gly Gly Tyr Arg Gly Arg Gly Gly Leu Gly 
                405                 410                 415     


Phe Arg Gly Gly Arg Gly Arg Gly Gly Gly Arg Gly Gly Thr Phe Thr 
            420                 425                 430         


Ala Pro Arg Gly Phe Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Arg 
        435                 440                 445             


Glu Phe Ala Asp Phe Glu Tyr Arg Lys Thr Thr Ala Phe Gly Pro 
    450                 455                 460             


<210> 7673
<211> 929
<212> PRT
<213> Homo sapiens

<400> 7673
Met Ala Glu Val Glu Ala Val Gln Leu Lys Glu Glu Gly Asn Arg His 
1               5                   10                  15      


Phe Gln Leu Gln Asp Tyr Lys Ala Ala Thr Asn Ser Tyr Ser Gln Ala 
            20                  25                  30          


Leu Lys Leu Thr Lys Asp Lys Ala Leu Leu Ala Thr Leu Tyr Arg Asn 
        35                  40                  45              


Arg Ala Ala Cys Gly Leu Lys Thr Glu Ser Tyr Val Gln Ala Ala Ser 
    50                  55                  60                  


Asp Ala Ser Arg Ala Ile Asp Ile Asn Ser Ser Asp Ile Lys Ala Leu 
65                  70                  75                  80  


Tyr Arg Arg Cys Gln Ala Leu Glu His Leu Gly Lys Leu Asp Gln Ala 
                85                  90                  95      


Phe Lys Asp Val Gln Arg Cys Ala Thr Leu Glu Pro Arg Asn Gln Asn 
            100                 105                 110         


Phe Gln Glu Met Leu Arg Arg Leu Asn Thr Ser Ile Gln Glu Lys Leu 
        115                 120                 125             


Arg Val Gln Phe Ser Thr Asp Ser Arg Val Gln Lys Met Phe Glu Ile 
    130                 135                 140                 


Leu Leu Asp Glu Asn Ser Glu Ala Asp Lys Arg Glu Lys Ala Ala Asn 
145                 150                 155                 160 


Asn Leu Ile Val Leu Gly Arg Glu Glu Ala Gly Ala Glu Lys Ile Phe 
                165                 170                 175     


Gln Asn Asn Gly Val Ala Leu Leu Leu Gln Leu Leu Asp Thr Lys Lys 
            180                 185                 190         


Pro Glu Leu Val Leu Ala Ala Val Arg Thr Leu Ser Gly Met Cys Ser 
        195                 200                 205             


Gly His Gln Ala Arg Ala Thr Val Ile Leu His Ala Val Arg Ile Asp 
    210                 215                 220                 


Arg Ile Cys Ser Leu Met Ala Val Glu Asn Glu Glu Met Ser Leu Ala 
225                 230                 235                 240 


Val Cys Asn Leu Leu Gln Ala Ile Ile Asp Ser Leu Ser Gly Glu Asp 
                245                 250                 255     


Lys Arg Glu His Arg Gly Lys Glu Glu Ala Leu Val Leu Asp Thr Lys 
            260                 265                 270         


Lys Asp Leu Lys Gln Ile Thr Ser His Leu Leu Asp Met Leu Val Ser 
        275                 280                 285             


Lys Lys Val Ser Gly Gln Gly Arg Asp Gln Ala Leu Asn Leu Leu Asn 
    290                 295                 300                 


Lys Asn Val Pro Arg Lys Asp Leu Ala Ile His Asp Asn Ser Arg Thr 
305                 310                 315                 320 


Ile Tyr Val Val Asp Asn Gly Leu Arg Lys Ile Leu Lys Val Val Gly 
                325                 330                 335     


Gln Val Pro Asp Leu Pro Ser Cys Leu Pro Leu Thr Asp Asn Thr Arg 
            340                 345                 350         


Met Leu Ala Ser Ile Leu Ile Asn Lys Leu Tyr Asp Asp Leu Arg Cys 
        355                 360                 365             


Asp Pro Glu Arg Asp His Phe Arg Lys Ile Cys Glu Glu Tyr Ile Thr 
    370                 375                 380                 


Gly Lys Phe Asp Pro Gln Asp Met Asp Lys Asn Leu Asn Ala Ile Gln 
385                 390                 395                 400 


Thr Val Ser Gly Ile Leu Gln Gly Pro Phe Asp Leu Gly Asn Gln Leu 
                405                 410                 415     


Leu Gly Leu Lys Gly Val Met Glu Met Met Val Ala Leu Cys Gly Ser 
            420                 425                 430         


Glu Arg Glu Thr Asp Gln Leu Val Ala Val Glu Ala Leu Ile His Ala 
        435                 440                 445             


Ser Thr Lys Leu Ser Arg Ala Thr Phe Ile Ile Thr Asn Gly Val Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ile Tyr Lys Thr Thr Lys Asn Glu Lys Ile Lys Ile 
465                 470                 475                 480 


Arg Thr Leu Val Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr Asp 
                485                 490                 495     


Tyr Gly Leu Arg Gln Phe Ala Glu Gly Ser Thr Glu Lys Leu Ala Lys 
            500                 505                 510         


Gln Cys Arg Lys Trp Leu Cys Asn Met Ser Ile Asp Thr Arg Thr Arg 
        515                 520                 525             


Arg Trp Ala Val Glu Gly Leu Ala Tyr Leu Thr Leu Asp Ala Asp Val 
    530                 535                 540                 


Lys Asp Asp Phe Val Gln Asp Val Pro Ala Leu Gln Ala Met Phe Glu 
545                 550                 555                 560 


Leu Ala Lys Thr Ser Asp Lys Thr Ile Leu Tyr Ser Val Ala Thr Thr 
                565                 570                 575     


Leu Val Asn Cys Thr Asn Ser Tyr Asp Val Lys Glu Val Ile Pro Glu 
            580                 585                 590         


Leu Val Gln Leu Ala Lys Phe Ser Lys Gln His Val Pro Glu Glu His 
        595                 600                 605             


Pro Lys Asp Lys Lys Asp Phe Ile Asp Met Arg Val Lys Arg Leu Leu 
    610                 615                 620                 


Lys Ala Gly Val Ile Ser Ala Leu Ala Cys Met Val Lys Ala Asp Ser 
625                 630                 635                 640 


Ala Ile Leu Thr Asp Gln Thr Lys Glu Leu Leu Ala Arg Val Phe Leu 
                645                 650                 655     


Ala Leu Cys Asp Asn Pro Lys Asp Arg Gly Thr Ile Val Ala Gln Gly 
            660                 665                 670         


Gly Gly Lys Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp Val Gly 
        675                 680                 685             


Lys Val Lys Ala Ala His Ala Leu Ala Lys Ile Ala Ala Val Ser Asn 
    690                 695                 700                 


Pro Asp Ile Ala Phe Pro Gly Glu Arg Val Tyr Glu Val Val Arg Pro 
705                 710                 715                 720 


Leu Val Arg Leu Leu Asp Thr Gln Arg Asp Gly Leu Gln Asn Tyr Glu 
                725                 730                 735     


Ala Leu Leu Gly Leu Thr Asn Leu Ser Gly Arg Ser Asp Lys Leu Arg 
            740                 745                 750         


Gln Lys Ile Phe Lys Glu Arg Ala Leu Pro Asp Ile Glu Asn Tyr Met 
        755                 760                 765             


Phe Glu Asn His Asp Gln Leu Arg Gln Ala Ala Thr Glu Cys Met Cys 
    770                 775                 780                 


Asn Met Val Leu His Lys Glu Val Gln Glu Arg Phe Leu Ala Asp Gly 
785                 790                 795                 800 


Asn Asp Arg Leu Lys Leu Val Val Leu Leu Cys Gly Glu Asp Asp Asp 
                805                 810                 815     


Lys Val Gln Asn Ala Ala Ala Gly Ala Leu Ala Met Leu Thr Ala Ala 
            820                 825                 830         


His Lys Lys Leu Cys Leu Lys Met Thr Gln Val Thr Thr Gln Trp Leu 
        835                 840                 845             


Glu Ile Leu Gln Arg Leu Cys Leu His Asp Gln Leu Ser Val Gln His 
    850                 855                 860                 


Arg Gly Leu Val Ile Ala Tyr Asn Leu Leu Ala Ala Asp Ala Glu Leu 
865                 870                 875                 880 


Ala Lys Lys Leu Val Glu Ser Glu Leu Leu Glu Ile Leu Thr Val Val 
                885                 890                 895     


Gly Lys Gln Glu Pro Asp Glu Lys Lys Ala Glu Val Val Gln Thr Ala 
            900                 905                 910         


Arg Glu Cys Leu Ile Lys Cys Met Asp Tyr Gly Phe Ile Lys Pro Val 
        915                 920                 925             


Ser 
    


<210> 7674
<211> 81
<212> PRT
<213> Homo sapiens

<400> 7674
Met Ser His Tyr Gly Ser Tyr Tyr Gly Gly Leu Gly Tyr Ser Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          


Cys Arg Arg Gly Ser Gly Cys Gly Tyr Gly Gly Tyr Gly Tyr Gly Ser 
        35                  40                  45              


Gly Phe Gly Gly Tyr Gly Tyr Gly Ser Gly Phe Gly Gly Tyr Gly Tyr 
    50                  55                  60                  


Gly Cys Cys Arg Pro Ser Tyr Asn Gly Gly Tyr Gly Phe Ser Gly Phe 
65                  70                  75                  80  


Tyr 
    


<210> 7675
<211> 49
<212> PRT
<213> Homo sapiens

<400> 7675
Met Glu Val Pro Arg Leu Asp His Ala Leu Asn Ser Pro Thr Ser Pro 
1               5                   10                  15      


Cys Glu Glu Val Ile Lys Asn Leu Ser Leu Glu Ala Ile Gln Leu Cys 
            20                  25                  30          


Asp Arg Asp Val Val Phe Glu Glu Leu Thr Ser Lys Gln Thr Arg Lys 
        35                  40                  45              


Gly 
    


<210> 7676
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7676
Met Ser Arg Tyr Leu Arg Pro Pro Asn Thr Ser Leu Phe Val Arg Asn 
1               5                   10                  15      


Val Ala Asp Asp Thr Arg Ser Glu Asp Leu Arg Arg Glu Phe Gly Arg 
            20                  25                  30          


Tyr Gly Pro Ile Val Asp Val Tyr Val Pro Leu Asp Phe Tyr Thr Arg 
        35                  40                  45              


Arg Pro Arg Gly Phe Ala Tyr Val Gln Phe Glu Asp Val Arg Asp Ala 
    50                  55                  60                  


Glu Asp Ala Leu His Asn Leu Asp Arg Lys Trp Ile Cys Gly Arg Gln 
65                  70                  75                  80  


Ile Glu Ile Gln Phe Ala Gln Gly Asp Arg Lys Thr Pro Asn Gln Met 
                85                  90                  95      


Lys Ala Lys Glu Gly Arg Asn Val Tyr Ser Ser Ser Arg Tyr Asp Asp 
            100                 105                 110         


Tyr Asp Arg Tyr Arg Arg Ser Arg Ser Arg Ser Tyr Glu Arg Arg Arg 
        115                 120                 125             


Ser Arg Ser Arg Ser Phe Asp Tyr Asn Tyr Arg Arg Ser Tyr Ser Pro 
    130                 135                 140                 


Arg Lys Pro Asn Cys Ser Trp Asn Thr Gln Tyr Ser Ser Ala Tyr Tyr 
145                 150                 155                 160 


Thr Ser Arg Lys Ile 
                165 


<210> 7677
<211> 600
<212> PRT
<213> Homo sapiens

<400> 7677
Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser Val 
        115                 120                 125             


Tyr Leu Ser Tyr Glu Lys Arg Ala Glu Thr Leu Ala Val Glu Ile Lys 
    130                 135                 140                 


Glu Leu Gln Gly Gln Leu Ala Asp Tyr Asn Met Leu Val Asp Lys Leu 
145                 150                 155                 160 


Asn Thr Asn Thr Glu Met Glu Glu Val Met Asn Asp Tyr Asn Met Leu 
                165                 170                 175     


Lys Ala Gln Asn Asp Arg Glu Thr Gln Ser Leu Asp Val Ile Phe Thr 
            180                 185                 190         


Glu Arg Gln Ala Lys Glu Lys Gln Ile Arg Ser Val Glu Glu Glu Ile 
        195                 200                 205             


Glu Gln Glu Lys Gln Ala Thr Asp Asp Ile Ile Lys Asn Met Ser Phe 
    210                 215                 220                 


Glu Asn Gln Val Lys Tyr Leu Glu Met Lys Thr Thr Asn Glu Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Asp Thr Leu Gln Gln Gln Leu Asp Ser Gln Asn Met 
                245                 250                 255     


Lys Lys Glu Ser Leu Glu Ala Glu Ile Ala His Ser Gln Val Lys Gln 
            260                 265                 270         


Glu Ala Val Leu Leu His Glu Lys Leu Tyr Glu Leu Glu Ser His Arg 
        275                 280                 285             


Asp Gln Met Ile Ala Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala 
305                 310                 315                 320 


Ser Met Glu Arg Gln Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe 
                325                 330                 335     


Ile Glu Glu Ile Arg Gln Leu Asp Met Asp Leu Glu Glu His Gln Gly 
            340                 345                 350         


Glu Met Asn Gln Lys Tyr Lys Glu Leu Lys Lys Arg Glu Glu His Met 
        355                 360                 365             


Asp Thr Phe Ile Glu Thr Phe Glu Glu Thr Lys Asn Gln Glu Leu Lys 
    370                 375                 380                 


Arg Lys Ala Gln Ile Glu Ala Asn Ile Val Ala Leu Leu Glu His Cys 
385                 390                 395                 400 


Ser Arg Asn Ile Asn Arg Ile Glu Gln Ile Ser Ser Ile Thr Asn Gln 
                405                 410                 415     


Glu Leu Lys Met Met Gln Asp Asp Leu Asn Phe Lys Ser Thr Glu Val 
            420                 425                 430         


Gln Lys Ser Gln Ser Thr Ala Gln Asn Leu Thr Ser Asp Ile Gln Arg 
        435                 440                 445             


Leu Gln Leu Asp Leu Gln Lys Met Glu Leu Leu Glu Ser Lys Met Thr 
    450                 455                 460                 


Glu Glu Gln His Ser Leu Lys Ser Lys Ile Lys Gln Met Thr Thr Asp 
465                 470                 475                 480 


Leu Glu Ile Tyr Asn Asp Leu Pro Ala Leu Lys Ser Ser Gly Glu Glu 
                485                 490                 495     


Lys Ile Lys Lys Leu His Gln Glu Arg Met Ile Leu Ser Thr His Arg 
            500                 505                 510         


Asn Ala Phe Lys Lys Ile Met Glu Lys Gln Asn Ile Glu Tyr Glu Ala 
        515                 520                 525             


Leu Lys Thr Gln Leu Gln Glu Asn Glu Thr His Ser Gln Leu Thr Asn 
    530                 535                 540                 


Leu Glu Arg Lys Trp Gln His Leu Glu Gln Asn Asn Phe Ala Met Lys 
545                 550                 555                 560 


Glu Phe Ile Ala Thr Lys Ser Gln Glu Ser Asp Tyr Gln Pro Ile Lys 
                565                 570                 575     


Lys Asn Val Thr Lys Gln Ile Ala Glu Tyr Asn Lys Thr Ile Val Asp 
            580                 585                 590         


Ala Leu His Ser Thr Ser Gly Asn 
        595                 600 


<210> 7678
<211> 154
<212> PRT
<213> Homo sapiens

<400> 7678
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg 
            100                 105                 110         


Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys 
        115                 120                 125             


Thr Glu Ala Gln Ala Phe Thr Glu Thr Lys Gly Asn Val Ile Cys Leu 
    130                 135                 140                 


Gly Lys Glu Val Phe Lys Gly Lys Lys Pro 
145                 150                 


<210> 7679
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7679
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 7680
<211> 115
<212> PRT
<213> Homo sapiens

<400> 7680
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro 
        115 


<210> 7681
<211> 143
<212> PRT
<213> Homo sapiens

<400> 7681
Val Arg Glu Leu Glu Ala Glu Leu Asp Ala Glu Gln Lys Lys His Ala 
1               5                   10                  15      


Glu Ala Leu Lys Gly Val Arg Lys His Glu Arg Arg Val Lys Glu Leu 
            20                  25                  30          


Ala Tyr Gln Val Gly Asp Arg Val Ser Leu Gly Ser Gly Pro Gly Ala 
        35                  40                  45              


Gly Pro Ala Gln Ala Ser Pro Glu Ser Pro Leu Pro Ala Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Lys Asn Leu Ala Arg Met Gln Asp Leu Val Asp Lys Leu 
65                  70                  75                  80  


Gln Ser Lys Val Lys Ser Tyr Lys Arg Gln Phe Glu Glu Ala Glu Gln 
                85                  90                  95      


Gln Ala Asn Thr Asn Leu Ala Lys Tyr Arg Lys Ala Gln His Glu Leu 
            100                 105                 110         


Asp Asp Ala Glu Glu Arg Ala Asp Met Ala Glu Thr Gln Ala Asn Lys 
        115                 120                 125             


Leu Arg Ala Arg Thr Arg Asp Ala Leu Gly Pro Lys His Lys Glu 
    130                 135                 140             


<210> 7682
<211> 275
<212> PRT
<213> Homo sapiens

<400> 7682
Met Ser Thr Ile Gly Ser Phe Glu Gly Phe Gln Ala Val Ser Leu Lys 
1               5                   10                  15      


Gln Glu Gly Asp Asp Gln Pro Ser Glu Thr Asp His Leu Ser Met Glu 
            20                  25                  30          


Glu Glu Asp Pro Met Pro Arg Gln Ile Ser Arg Gln Ser Ser Val Thr 
        35                  40                  45              


Glu Ser Thr Leu Tyr Pro Asn Pro Tyr His Gln Pro Tyr Ile Ser Arg 
    50                  55                  60                  


Lys Tyr Phe Ala Thr Arg Pro Gly Ala Ile Glu Thr Ala Met Glu Asp 
65                  70                  75                  80  


Leu Lys Gly His Val Ala Glu Thr Ser Gly Glu Thr Ile Gln Gly Phe 
                85                  90                  95      


Trp Leu Leu Thr Lys Ile Asp His Trp Asn Asn Glu Lys Glu Arg Ile 
            100                 105                 110         


Leu Leu Val Thr Asp Lys Thr Leu Leu Ile Cys Lys Tyr Asp Phe Ile 
        115                 120                 125             


Met Leu Ser Cys Val Gln Leu Gln Arg Ile Pro Leu Ser Ala Val Tyr 
    130                 135                 140                 


Arg Ile Cys Leu Gly Lys Phe Thr Phe Pro Gly Met Ser Leu Asp Lys 
145                 150                 155                 160 


Arg Gln Gly Glu Gly Leu Arg Ile Tyr Trp Gly Ser Pro Glu Glu Gln 
                165                 170                 175     


Ser Leu Leu Ser Arg Trp Asn Pro Trp Ser Thr Glu Val Pro Tyr Ala 
            180                 185                 190         


Thr Phe Thr Glu His Pro Met Lys Tyr Thr Ser Glu Lys Phe Leu Glu 
        195                 200                 205             


Ile Cys Lys Leu Ser Gly Phe Met Ser Lys Leu Val Pro Ala Ile Gln 
    210                 215                 220                 


Asn Ala His Lys Asn Ser Thr Gly Ser Gly Arg Gly Lys Lys Leu Met 
225                 230                 235                 240 


Val Leu Thr Glu Pro Ile Leu Ile Glu Thr Tyr Thr Gly Leu Met Ser 
                245                 250                 255     


Phe Ile Gly Asn Arg Asn Lys Leu Gly Tyr Ser Leu Ala Arg Gly Ser 
            260                 265                 270         


Ile Gly Phe 
        275 


<210> 7683
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7683
Xaa Cys Ala Arg Thr Ala Gly Gly Cys Leu Gly Cys Leu Ser Gly Gln 
1               5                   10                  15      


Cys Cys Cys Arg Leu Cys Pro Leu Thr Leu Pro Ala Thr Arg Ser Leu 
            20                  25                  30          


Cys Pro Gly Arg Val Val Trp Ala Arg Arg Arg Trp Trp Pro Ser Trp 
        35                  40                  45              


Leu Ala Trp Arg Cys Leu Trp Cys Thr Thr Arg Pro Pro Ala Cys Met 
    50                  55                  60                  


Glu Asn Thr Asp Ala Phe Leu Phe Leu Phe Ser Phe Thr Asp Arg Ala 
65                  70                  75                  80  


Ser Phe Glu Asp Leu Pro Gly Gln Leu Ala Arg Ile Ala Gly Glu Ala 
                85                  90                  95      


Pro Gly Val Val Arg Met Val Ile Gly Ser Lys Phe Asp Gln Tyr Met 
            100                 105                 110         


<210> 7684
<211> 1109
<212> PRT
<213> Homo sapiens

<400> 7684
Met Gly Thr Gly Asp Phe Ile Cys Ile Ser Met Thr Gly Gly Ala Pro 
1               5                   10                  15      


Trp Gly Phe Arg Leu Gln Gly Gly Lys Glu Gln Lys Gln Pro Leu Gln 
            20                  25                  30          


Val Ala Lys Ile Arg Asn Gln Ser Lys Ala Ser Gly Ser Gly Leu Cys 
        35                  40                  45              


Glu Gly Asp Glu Val Val Ser Ile Asn Gly Asn Pro Cys Ala Asp Leu 
    50                  55                  60                  


Thr Tyr Pro Glu Val Ile Lys Leu Met Glu Ser Ile Thr Asp Ser Leu 
65                  70                  75                  80  


Gln Met Leu Ile Lys Arg Pro Ser Ser Gly Ile Ser Glu Ala Leu Ile 
                85                  90                  95      


Ser Glu Asn Glu Asn Lys Asn Leu Glu His Leu Thr His Gly Gly Tyr 
            100                 105                 110         


Val Glu Ser Thr Thr Leu Gln Ile Arg Pro Ala Thr Lys Thr Gln Cys 
        115                 120                 125             


Thr Glu Phe Phe Leu Ala Pro Val Lys Thr Glu Val Pro Leu Ala Glu 
    130                 135                 140                 


Asn Gln Arg Ser Gly Pro Asp Cys Ala Gly Ser Leu Lys Glu Glu Thr 
145                 150                 155                 160 


Gly Pro Ser Tyr Gln Arg Ala Pro Gln Met Pro Asp Ser Gln Arg Gly 
                165                 170                 175     


Arg Val Ala Glu Glu Leu Ile Leu Arg Glu Lys Val Glu Ala Val Gln 
            180                 185                 190         


Pro Gly Pro Val Val Glu Leu Gln Leu Ser Leu Ser Gln Glu Arg His 
        195                 200                 205             


Lys Gly Ala Ser Gly Pro Leu Val Ala Leu Pro Gly Ala Glu Lys Ser 
    210                 215                 220                 


Lys Ser Pro Asp Pro Asp Pro Asn Leu Ser His Asp Arg Ile Val His 
225                 230                 235                 240 


Ile Asn Ser Ile Pro Thr Asn Glu Lys Ala Asp Pro Phe Leu Arg Ser 
                245                 250                 255     


Ser Lys Ile Ile Gln Ile Ser Ser Gly Arg Glu Leu Arg Val Ile Gln 
            260                 265                 270         


Glu Ser Glu Ala Gly Asp Ala Gly Leu Pro Arg Val Glu Val Ile Leu 
        275                 280                 285             


Asp Cys Ser Asp Arg Gln Lys Thr Glu Gly Cys Arg Leu Gln Ala Gly 
    290                 295                 300                 


Lys Glu Cys Val Asp Ser Pro Val Glu Gly Gly Gln Ser Glu Ala Pro 
305                 310                 315                 320 


Pro Ser Leu Val Ser Phe Ala Val Ser Ser Glu Gly Thr Glu Gln Gly 
                325                 330                 335     


Glu Asp Pro Arg Ser Glu Lys Asp His Ser Arg Pro His Lys His Arg 
            340                 345                 350         


Ala Arg His Ala Arg Leu Arg Arg Ser Glu Ser Leu Ser Glu Lys Gln 
        355                 360                 365             


Val Lys Glu Ala Lys Ser Lys Cys Lys Ser Ile Ala Leu Leu Leu Thr 
    370                 375                 380                 


Asp Ala Pro Asn Pro Asn Ser Lys Gly Val Leu Met Phe Lys Lys Arg 
385                 390                 395                 400 


Arg Arg Arg Ala Arg Lys Tyr Thr Leu Val Ser Tyr Gly Thr Gly Glu 
                405                 410                 415     


Leu Glu Arg Glu Ala Asp Glu Glu Glu Glu Gly Asp Lys Glu Asp Thr 
            420                 425                 430         


Cys Glu Val Ala Phe Leu Gly Ala Ser Glu Ser Glu Val Asp Glu Glu 
        435                 440                 445             


Leu Leu Ser Asp Val Asp Asp Asn Thr Gln Val Val Asn Phe Asp Trp 
    450                 455                 460                 


Asp Ser Gly Leu Val Asp Ile Glu Lys Lys Leu Asn Arg Gly Asp Lys 
465                 470                 475                 480 


Met Glu Met Leu Pro Asp Thr Thr Gly Lys Gly Ala Leu Met Phe Ala 
                485                 490                 495     


Lys Arg Arg Glu Arg Met Asp Gln Ile Thr Ala Gln Lys Glu Glu Asp 
            500                 505                 510         


Lys Val Gly Gly Thr Pro Ser Arg Glu Gln Asp Ala Ala Gln Thr Asp 
        515                 520                 525             


Gly Leu Arg Thr Thr Thr Ser Tyr Gln Arg Lys Glu Glu Glu Ser Val 
    530                 535                 540                 


Arg Thr Gln Ser Ser Val Ser Lys Ser Tyr Ile Glu Val Ser His Gly 
545                 550                 555                 560 


Leu Gly His Val Pro Gln Gln Asn Gly Phe Ser Gly Thr Ser Glu Thr 
                565                 570                 575     


Ala Asn Ile Gln Arg Met Val Pro Met Asn Arg Thr Ala Lys Pro Phe 
            580                 585                 590         


Pro Gly Ser Val Asn Gln Pro Ala Thr Pro Phe Ser Pro Thr Arg Asn 
        595                 600                 605             


Met Thr Ser Pro Ile Ala Asp Phe Pro Ala Pro Pro Pro Tyr Ser Ala 
    610                 615                 620                 


Val Thr Pro Pro Pro Asp Ala Phe Ser Arg Gly Val Ser Ser Pro Ile 
625                 630                 635                 640 


Ala Gly Pro Ala Gln Pro Pro Pro Trp Pro Gln Pro Ala Pro Trp Ser 
                645                 650                 655     


Gln Pro Ala Phe Tyr Asp Ser Ser Glu Arg Ile Ala Ser Arg Asp Glu 
            660                 665                 670         


Arg Ile Ser Val Pro Ala Lys Arg Thr Gly Ile Leu Gln Glu Ala Lys 
        675                 680                 685             


Arg Arg Ser Thr Thr Lys Pro Met Phe Thr Phe Lys Glu Pro Lys Val 
    690                 695                 700                 


Ser Pro Asn Pro Glu Leu Leu Ser Leu Leu Gln Asn Ser Glu Gly Lys 
705                 710                 715                 720 


Arg Gly Thr Gly Ala Gly Gly Asp Ser Gly Pro Glu Glu Asp Tyr Leu 
                725                 730                 735     


Ser Leu Gly Ala Glu Ala Cys Asn Phe Met Gln Ser Ser Ser Ala Lys 
            740                 745                 750         


Gln Lys Thr Pro Pro Pro Val Ala Pro Lys Pro Ala Val Lys Ser Ser 
        755                 760                 765             


Ser Ser Gln Pro Val Thr Pro Val Ser Pro Val Trp Ser Pro Gly Val 
    770                 775                 780                 


Ala Pro Thr Gln Pro Pro Ala Phe Pro Thr Ser Asn Pro Ser Lys Gly 
785                 790                 795                 800 


Thr Val Val Ser Ser Ile Lys Ile Ala Gln Pro Ser Tyr Pro Pro Ala 
                805                 810                 815     


Arg Pro Ala Ser Thr Leu Asn Val Ala Gly Pro Phe Lys Gly Pro Gln 
            820                 825                 830         


Ala Ala Val Ala Ser Gln Asn Tyr Thr Pro Lys Pro Thr Val Ser Thr 
        835                 840                 845             


Pro Thr Val Asn Ala Val Gln Pro Gly Ala Val Gly Pro Ser Asn Glu 
    850                 855                 860                 


Leu Pro Gly Met Ser Gly Arg Gly Ala Gln Leu Phe Ala Lys Arg Gln 
865                 870                 875                 880 


Ser Arg Met Glu Lys Tyr Val Val Asp Ser Asp Thr Val Gln Ala His 
                885                 890                 895     


Ala Ala Arg Ala Gln Ser Pro Thr Pro Ser Leu Pro Ala Ser Trp Lys 
            900                 905                 910         


Tyr Ser Ser Asn Val Arg Ala Pro Pro Pro Val Ala Tyr Asn Pro Ile 
        915                 920                 925             


His Ser Pro Ser Tyr Pro Leu Ala Ala Leu Lys Ser Gln Pro Ser Ala 
    930                 935                 940                 


Ala Gln Pro Ser Lys Met Gly Lys Lys Lys Gly Lys Lys Pro Leu Asn 
945                 950                 955                 960 


Ala Leu Asp Val Met Lys His Gln Pro Tyr Gln Leu Asn Ala Ser Leu 
                965                 970                 975     


Phe Thr Phe Gln Pro Pro Asp Ala Lys Asp Gly Leu Pro Gln Lys Ser 
            980                 985                 990         


Ser Val Lys Val Asn Ser Ala Leu  Ala Met Lys Gln Ala  Leu Pro Pro 
        995                 1000                 1005             


Arg Pro  Val Asn Ala Ala Ser  Pro Thr Asn Val Gln  Ala Ser Ser 
    1010                 1015                 1020             


Val Tyr  Ser Val Pro Ala Tyr  Thr Ser Pro Pro Ser  Phe Phe Ala 
    1025                 1030                 1035             


Glu Ala  Ser Ser Pro Val Ser  Ala Ser Pro Val Pro  Val Gly Ile 
    1040                 1045                 1050             


Pro Thr  Ser Pro Lys Gln Glu  Ser Ala Ser Ser Ser  Tyr Phe Val 
    1055                 1060                 1065             


Ala Pro  Arg Pro Lys Phe Ser  Ala Lys Lys Ser Gly  Val Thr Ile 
    1070                 1075                 1080             


Gln Val  Lys Cys Lys Ser Gly  Ile His Ser Gln Asp  Ile Ile Arg 
    1085                 1090                 1095             


Thr Tyr  Phe Pro Ala Tyr Leu  Ser Ser Ser Thr 
    1100                 1105                 


<210> 7685
<211> 517
<212> PRT
<213> Homo sapiens

<400> 7685
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Ser Ser Ser Arg Leu Ser Tyr Gln 
            260                 265                 270         


Pro Ala Ala Leu Gly Val Gly Ser Ala Asp Leu Ala Tyr Pro Val Val 
        275                 280                 285             


Phe Ala Ala Gly Leu Asn Ala Thr His Pro His Gln Leu Met Val Pro 
    290                 295                 300                 


Gly Lys Glu Gly Gly Val Pro Leu Ala Pro Asn Gln Pro Val His Gly 
305                 310                 315                 320 


Thr Gln Ala Asp Gln Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg 
                325                 330                 335     


Thr His Cys Ala Ala Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val 
            340                 345                 350         


Ser Asn Ser Ser Glu Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr 
        355                 360                 365             


Ile Phe Val Arg Lys Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln 
    370                 375                 380                 


Val Thr Leu Thr Ser Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys 
385                 390                 395                 400 


Asn Leu Glu Leu Glu Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser 
                405                 410                 415     


Pro Glu Thr Glu Ser Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser 
            420                 425                 430         


Ser Gly Gly Ser Ser Gly Asn Thr His Asp Asp Phe Val Met Ile Asp 
        435                 440                 445             


Phe Lys Pro Ala Phe Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly 
    450                 455                 460                 


Thr Phe Tyr Arg Glu Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser 
465                 470                 475                 480 


Ile Asp Ile Gly Ala Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro 
                485                 490                 495     


Glu Lys Leu Ala Val His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe 
            500                 505                 510         


Val Glu Thr Leu Gln 
        515         


<210> 7686
<211> 115
<212> PRT
<213> Homo sapiens

<400> 7686
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro 
        115 


<210> 7687
<211> 337
<212> PRT
<213> Homo sapiens

<400> 7687
Met Glu Leu Lys Thr Leu Trp Glu Asn Lys Leu Met Gln Ser Arg Ala 
1               5                   10                  15      


Val Asp Gly Phe His Ser Glu Glu Gln Gln Leu Leu Leu Gln Val Gln 
            20                  25                  30          


Gln Gln His Gln Pro Gln Gln Gln Gln His His His His His His His 
        35                  40                  45              


Gln Gln Ala Gln Pro Gln Gln Thr Val Pro Gln Gln Ala Gln Thr Gln 
    50                  55                  60                  


Gln Val Leu Ile Pro Ala Ser Gln Gln Ala Thr Ala Pro Gln Val Ile 
65                  70                  75                  80  


Val Pro Asp Ser Lys Leu Ile Gln His Met Asn Ala Ser Asn Met Ser 
                85                  90                  95      


Ala Ala Ala Thr Ala Ala Thr Leu Ala Leu Pro Ala Gly Val Thr Pro 
            100                 105                 110         


Val Gln Gln Ile Leu Thr Asn Ser Gly Gln Leu Leu Gln Val Val Arg 
        115                 120                 125             


Ala Ala Asn Gly Ala Gln Tyr Ile Phe Gln Pro Gln Gln Ser Val Val 
    130                 135                 140                 


Leu Gln Gln Gln Val Ile Pro Gln Met Gln Pro Gly Gly Val Gln Ala 
145                 150                 155                 160 


Pro Val Ile Gln Gln Val Leu Ala Pro Leu Pro Gly Gly Ile Ser Pro 
                165                 170                 175     


Gln Thr Gly Val Ile Ile Gln Pro Gln Gln Ile Leu Phe Thr Gly Asn 
            180                 185                 190         


Lys Thr Gln Val Ile Pro Thr Thr Val Ala Ala Pro Thr Pro Ala Gln 
        195                 200                 205             


Ala Gln Ile Thr Ala Thr Gly Gln Gln Gln Pro Gln Ala Gln Pro Ala 
    210                 215                 220                 


Gln Thr Gln Ala Pro Leu Val Leu Gln Val Asp Gly Thr Gly Asp Thr 
225                 230                 235                 240 


Ser Ser Glu Glu Asp Glu Asp Glu Glu Glu Asp Tyr Asp Asp Asp Glu 
                245                 250                 255     


Glu Glu Asp Lys Glu Lys Asp Gly Ala Glu Asp Gly Gln Val Glu Glu 
            260                 265                 270         


Glu Pro Leu Asn Ser Glu Asp Asp Val Ser Asp Glu Glu Gly Gln Glu 
        275                 280                 285             


Leu Phe Asp Thr Glu Asn Val Val Val Cys Gln Tyr Asp Lys Ile His 
    290                 295                 300                 


Arg Ser Lys Asn Lys Trp Lys Phe His Leu Lys Asp Gly Ile Met Asn 
305                 310                 315                 320 


Leu Asn Gly Arg Asp Tyr Ile Phe Ser Lys Ala Ile Gly Asp Ala Glu 
                325                 330                 335     


Trp 
    


<210> 7688
<211> 1003
<212> PRT
<213> Homo sapiens

<400> 7688
Met Ser Gln Trp Thr Pro Glu Tyr Asn Glu Leu Tyr Thr Leu Lys Val 
1               5                   10                  15      


Asp Met Lys Ser Glu Ile Pro Ser Asp Ala Pro Lys Thr Gln Glu Ser 
            20                  25                  30          


Leu Lys Gly Ile Leu Leu His Pro Glu Pro Ile Gly Ala Ala Lys Ser 
        35                  40                  45              


Phe Pro Ala Gly Val Glu Met Ile Asn Ser Lys Val Gly Asn Glu Phe 
    50                  55                  60                  


Ser His Leu Cys Asp Asp Ser Gln Lys Gln Glu Lys Glu Met Asn Gly 
65                  70                  75                  80  


Asn Gln Gln Glu Gln Glu Lys Ser Leu Val Val Arg Lys Lys Arg Lys 
                85                  90                  95      


Ser Gln Gln Ala Gly Pro Ser Tyr Val Gln Asn Cys Val Lys Glu Asn 
            100                 105                 110         


Gln Gly Ile Leu Gly Leu Arg Gln His Leu Gly Thr Pro Ser Asp Glu 
        115                 120                 125             


Asp Asn Asp Ser Ser Phe Ser Asp Cys Leu Ser Ser Pro Ser Ser Ser 
    130                 135                 140                 


Leu His Phe Gly Asp Ser Asp Thr Val Thr Ser Asp Glu Asp Lys Glu 
145                 150                 155                 160 


Val Ser Val Arg His Ser Gln Thr Ile Leu Asn Ala Lys Ser Arg Ser 
                165                 170                 175     


His Ser Ala Arg Ser His Lys Trp Pro Arg Thr Glu Thr Glu Ser Val 
            180                 185                 190         


Ser Gly Leu Leu Met Lys Arg Pro Cys Leu His Gly Ser Ser Leu Arg 
        195                 200                 205             


Arg Leu Pro Cys Arg Lys Arg Phe Val Lys Asn Asn Ser Ser Gln Arg 
    210                 215                 220                 


Thr Gln Lys Gln Lys Glu Arg Ile Leu Met Gln Arg Lys Lys Arg Glu 
225                 230                 235                 240 


Val Leu Ala Arg Arg Lys Tyr Ala Leu Leu Pro Ser Ser Ser Ser Ser 
                245                 250                 255     


Ser Glu Asn Asp Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Thr Glu 
            260                 265                 270         


Gly Glu Glu Asp Leu Phe Val Ser Ala Ser Glu Asn His Gln Asn Asn 
        275                 280                 285             


Pro Ala Val Pro Ser Gly Ser Ile Asp Glu Asp Val Val Val Ile Glu 
    290                 295                 300                 


Ala Ser Ser Thr Pro Gln Val Thr Ala Asn Glu Glu Ile Asn Val Thr 
305                 310                 315                 320 


Ser Thr Asp Ser Glu Val Glu Ile Val Thr Val Gly Glu Ser Tyr Arg 
                325                 330                 335     


Ser Arg Ser Thr Leu Gly His Ser Arg Ser His Trp Ser Gln Gly Ser 
            340                 345                 350         


Ser Ser His Ala Ser Arg Pro Gln Glu Pro Arg Asn Arg Ser Arg Ile 
        355                 360                 365             


Ser Thr Val Ile Gln Pro Leu Arg Gln Asn Ala Ala Glu Val Val Asp 
    370                 375                 380                 


Leu Thr Val Asp Glu Asp Glu Pro Thr Val Val Pro Thr Thr Ser Ala 
385                 390                 395                 400 


Arg Met Glu Ser Gln Ala Thr Ser Ala Ser Ile Asn Asn Ser Asn Pro 
                405                 410                 415     


Ser Thr Ser Glu Gln Ala Ser Asp Thr Ala Ser Ala Val Thr Ser Ser 
            420                 425                 430         


Gln Pro Ser Thr Val Ser Glu Thr Ser Ala Thr Leu Thr Ser Asn Ser 
        435                 440                 445             


Thr Thr Gly Thr Ser Ile Gly Asp Asp Ser Arg Arg Thr Thr Ser Ser 
    450                 455                 460                 


Ala Val Thr Glu Thr Gly Pro Pro Ala Met Pro Arg Leu Pro Ser Cys 
465                 470                 475                 480 


Cys Pro Gln His Ser Pro Cys Gly Gly Ser Ser Gln Asn His His Ala 
                485                 490                 495     


Leu Gly His Pro His Thr Ser Cys Phe Gln Gln His Gly His His Phe 
            500                 505                 510         


Gln His His His His His His His Thr Pro His Pro Ala Val Pro Val 
        515                 520                 525             


Ser Pro Ser Phe Ser Asp Pro Ala Cys Pro Val Glu Arg Pro Pro Gln 
    530                 535                 540                 


Val Gln Ala Pro Cys Gly Ala Asn Ser Ser Ser Gly Thr Ser Tyr His 
545                 550                 555                 560 


Glu Gln Gln Ala Leu Pro Val Asp Leu Ser Asn Ser Gly Ile Arg Ser 
                565                 570                 575     


His Gly Ser Gly Ser Phe His Gly Ala Ser Ala Phe Asp Pro Cys Cys 
            580                 585                 590         


Pro Val Ser Ser Ser Arg Ala Ala Ile Phe Gly His Gln Ala Ala Ala 
        595                 600                 605             


Ala Ala Pro Ser Gln Pro Leu Ser Ser Ile Asp Gly Tyr Gly Ser Ser 
    610                 615                 620                 


Met Val Ala Gln Pro Gln Pro Gln Pro Pro Pro Gln Pro Ser Leu Ser 
625                 630                 635                 640 


Ser Cys Arg His Tyr Met Pro Pro Pro Tyr Ala Ser Leu Thr Arg Pro 
                645                 650                 655     


Leu His His Gln Ala Ser Ala Cys Pro His Ser His Gly Asn Pro Pro 
            660                 665                 670         


Pro Gln Thr Gln Pro Pro Pro Gln Val Asp Tyr Val Ile Pro His Pro 
        675                 680                 685             


Val His Ala Phe His Ser Gln Ile Ser Ser His Ala Thr Ser His Pro 
    690                 695                 700                 


Val Ala Pro Pro Pro Pro Thr His Leu Ala Ser Thr Ala Ala Pro Ile 
705                 710                 715                 720 


Pro Gln His Leu Pro Pro Thr His Gln Pro Ile Ser His His Ile Pro 
                725                 730                 735     


Ala Thr Ala Pro Pro Ala Gln Arg Leu His Pro His Glu Val Met Gln 
            740                 745                 750         


Arg Met Glu Val Gln Arg Arg Arg Met Met Gln His Pro Thr Gly Leu 
        755                 760                 765             


Phe Val Phe Cys Val Ser Arg Arg Ala His Glu Arg Pro Pro Pro His 
    770                 775                 780                 


Pro His Arg Met His Pro Asn Tyr Gly His Gly His His Ile His Val 
785                 790                 795                 800 


Pro Gln Thr Met Ser Ser His Pro Arg Gln Ala Pro Glu Arg Ser Ala 
                805                 810                 815     


Trp Glu Leu Gly Ile Glu Ala Gly Val Thr Ala Ala Thr Tyr Thr Pro 
            820                 825                 830         


Gly Ala Leu His Pro His Leu Ala His Tyr His Ala Pro Pro Arg Leu 
        835                 840                 845             


His His Leu Gln Leu Gly Ala Leu Pro Leu Met Val Pro Asp Met Ala 
    850                 855                 860                 


Gly Tyr Pro His Ile Arg Tyr Ile Ser Ser Gly Leu Asp Gly Thr Ser 
865                 870                 875                 880 


Phe Arg Gly Pro Phe Arg Gly Asn Phe Glu Glu Leu Ile His Leu Glu 
                885                 890                 895     


Glu Arg Leu Gly Asn Val Asn Arg Gly Ala Ser Gln Gly Thr Ile Glu 
            900                 905                 910         


Arg Cys Thr Tyr Pro His Lys Tyr Lys Lys Val Thr Thr Asp Trp Phe 
        915                 920                 925             


Ser Gln Arg Lys Leu His Cys Lys Gln Asp Gly Glu Glu Gly Thr Glu 
    930                 935                 940                 


Glu Asp Thr Glu Glu Lys Cys Thr Ile Cys Leu Ser Ile Leu Glu Glu 
945                 950                 955                 960 


Gly Glu Asp Val Arg Arg Leu Pro Cys Met His Leu Phe His Gln Val 
                965                 970                 975     


Cys Val Asp Gln Trp Leu Ile Thr Asn Lys Lys Cys Pro Ile Cys Arg 
            980                 985                 990         


Val Asp Ile Glu Ala Gln Leu Pro  Ser Glu Ser 
        995                 1000             


<210> 7689
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 7689
Met Ala Glu Lys Glu Ala Arg Arg Lys Phe Lys Gln Ile Val Thr Ala 
1               5                   10                  15      


Val Tyr Phe Cys His Cys Arg Asn Ile Val His Arg Asp Leu Lys Ala 
            20                  25                  30          


Glu Asn Leu Leu Leu Asp Ala Asn Leu Asn Ile Lys Ile Ala Asp Phe 
        35                  40                  45              


Gly Phe Ser Asn Leu Phe Thr Pro Gly Gln Leu Leu Lys Thr Trp Cys 
    50                  55                  60                  


Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe Glu Gly Lys Glu Tyr 
65                  70                  75                  80  


Asp Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Val Val Leu Tyr Val 
                85                  90                  95      


Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Ser Thr Leu Gln Asn Leu 
            100                 105                 110         


Arg Ala Arg Val Leu Ser Gly Lys Phe Arg Ile Pro Phe Phe Met Ser 
        115                 120                 125             


Thr Glu Cys Glu His Leu Ile Arg His Met Leu Val Leu Asp Pro Asn 
    130                 135                 140                 


Lys Arg Leu Ser Met Glu Gln Ile Cys Lys His Lys Trp Met Lys Leu 
145                 150                 155                 160 


Gly Asp Ala Asp Pro Asn Phe Asp Arg Leu Ile Ala Glu Cys Gln Gln 
                165                 170                 175     


Leu Lys Glu Glu Arg Gln Val Asp Pro Leu Asn Glu Asp Val Leu Leu 
            180                 185                 190         


Ala Met Glu Asp Met Gly Leu Asp Lys Glu Gln Thr Leu Gln Ser Leu 
        195                 200                 205             


Arg Ser Asp Ala Tyr Asp His Tyr Ser Ala Ile Tyr Ser Leu Leu Cys 
    210                 215                 220                 


Asp Arg His Lys Arg His Lys Thr Leu Arg Leu Gly Ala Leu Pro Ser 
225                 230                 235                 240 


Met Pro Arg Ala Leu Ala Phe Gln Ala Pro Val Asn Ile Gln Ala Glu 
                245                 250                 255     


Gln Ala Gly Thr Ala Met Asn Ile Ser Val Pro Gln Val Gln Leu Ile 
            260                 265                 270         


Asn Pro Glu Asn Gln Ile Val Glu Pro Asp Gly Thr Leu Asn Leu Asp 
        275                 280                 285             


Ser Asp Glu Gly Glu Glu Pro Ser Pro Glu Ala Leu Val Arg Tyr Leu 
    290                 295                 300                 


Ser Met Arg Arg His Thr Val Gly Val Ala Asp Pro Arg Thr Glu Val 
305                 310                 315                 320 


Met Glu Asp Leu Gln Lys Leu Leu Pro Gly Phe Pro Gly Val Asn Pro 
                325                 330                 335     


Gln Ala Pro Phe Leu Gln Val Ala Pro Asn Val Asn Phe Met His Asn 
            340                 345                 350         


Leu Leu Pro Met Gln Asn Leu Gln Pro Thr Gly Gln Leu Glu Tyr Lys 
        355                 360                 365             


Glu Gln Ser Leu Leu Gln Pro Pro Thr Leu Gln Leu Leu Asn Gly Met 
    370                 375                 380                 


Gly Pro Leu Gly Arg Arg Ala Ser Asp Gly Gly Ala Asn Ile Gln Leu 
385                 390                 395                 400 


His Ala Gln Gln Leu Leu Lys Arg Pro Arg Gly Pro Ser Pro Leu Val 
                405                 410                 415     


Thr Met Thr Pro Ala Val Pro Ala Val Thr Pro Val Asp Glu Glu Ser 
            420                 425                 430         


Ser Asp Gly Glu Pro Asp Gln Glu Ala Val Gln Ser Ser Thr Tyr Lys 
        435                 440                 445             


Asp Ser Asn Thr Leu His Leu Pro Thr Glu Arg Phe Ser Pro Val Arg 
    450                 455                 460                 


Arg Phe Ser Asp Gly Ala Ala Ser Ile Gln Ala Phe Lys Ala His Leu 
465                 470                 475                 480 


Glu Lys Met Gly Asn Asn Ser Ser Ile Lys Gln Leu Gln Gln Glu Cys 
                485                 490                 495     


Glu Gln Leu Gln Lys Met Tyr Gly Gly Gln Ile Asp Glu Arg Thr Leu 
            500                 505                 510         


Glu Lys Thr Gln Gln Gln His Met Leu Tyr Gln Gln Glu Gln His His 
        515                 520                 525             


Gln Ile Leu Gln Gln Gln Ile Gln Asp Ser Ile Cys Pro Pro Gln Pro 
    530                 535                 540                 


Ser Pro Pro Leu Gln Ala Ala Cys Glu Asn Gln Pro Ala Leu Leu Thr 
545                 550                 555                 560 


His Gln Leu Gln Arg Leu Arg Ile Gln Pro Ser Ser Pro Pro Pro Asn 
                565                 570                 575     


His Pro Asn Asn His Leu Phe Arg Gln Pro Ser Asn Ser Pro Pro Pro 
            580                 585                 590         


Met Ser Ser Ala Met Ile Gln Pro His Gly Ala Ala Ser Ser Ser Gln 
        595                 600                 605             


Phe Gln Gly Leu Pro Ser Arg Ser Ala Ile Phe Gln Gln Gln Pro Glu 
    610                 615                 620                 


Asn Cys Ser Ser Pro Pro Asn Val Ala Leu Thr Cys Leu Gly Met Gln 
625                 630                 635                 640 


Gln Pro Ala Gln Ser Gln Gln Val Thr Ile Gln Val Gln Glu Pro Val 
                645                 650                 655     


Asp Met Leu Ser Asn Met Pro Gly Thr Ala Ala Gly Ser Ser Gly Arg 
            660                 665                 670         


Gly Ile Ser Ile Ser Pro Ser Ala Gly Gln Met Gln Met Gln His Arg 
        675                 680                 685             


Thr Asn Leu Met Ala Thr Leu Ser Tyr Gly His Arg Pro Leu Ser Lys 
    690                 695                 700                 


Gln Leu Ser Ala Asp Ser Ala Glu Ala His Ser Ala His Gln Gln Pro 
705                 710                 715                 720 


Pro His Tyr Thr Thr Ser Ala Leu Gln Gln Ala Leu Leu Ser Pro Thr 
                725                 730                 735     


Pro Pro Asp Tyr Thr Arg His Gln Gln Val Pro His Ile Leu Gln Gly 
            740                 745                 750         


Leu Leu Ser Pro Arg His Ser Leu Thr Gly His Ser Asp Ile Arg Leu 
        755                 760                 765             


Pro Pro Thr Glu Phe Ala Gln Leu Ile Lys Arg Gln Gln Gln Gln Arg 
    770                 775                 780                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Tyr Gln Glu Leu Phe 
785                 790                 795                 800 


Arg His Met Asn Gln Gly Asp Ala Gly Ser Leu Ala Pro Ser Leu Gly 
                805                 810                 815     


Gly Gln Ser Met Thr Glu Arg Gln Ala Leu Ser Tyr Gln Asn Ala Asp 
            820                 825                 830         


Ser Tyr His His His Thr Ser Pro Gln His Leu Leu Gln Ile Arg Ala 
        835                 840                 845             


Gln Glu Cys Val Ser Gln Ala Ser Ser Pro Thr Pro Pro His Gly Tyr 
    850                 855                 860                 


Ala His Gln Pro Ala Leu Met His Ser Glu Ser Met Glu Glu Asp Cys 
865                 870                 875                 880 


Ser Cys Glu Gly Ala Lys Asp Gly Phe Gln Asp Ser Lys Ser Ser Ser 
                885                 890                 895     


Thr Leu Thr Lys Gly Cys His Asp Ser Pro Leu Leu Leu Ser Thr Gly 
            900                 905                 910         


Gly Pro Gly Asp Pro Glu Ser Leu Leu Gly Thr Val Ser His Ala Gln 
        915                 920                 925             


Glu Leu Gly Ile His Pro Tyr Gly His Gln Pro Thr Ala Ala Phe Ser 
    930                 935                 940                 


Lys Asn Lys Val Pro Ser Arg Glu Pro Val Ile Gly Asn Cys Met Asp 
945                 950                 955                 960 


Arg Ser Ser Pro Gly Gln Ala Val Glu Leu Pro Asp His Asn Gly Leu 
                965                 970                 975     


Gly Tyr Pro Ala Arg Pro Ser Val His Glu His His Arg Pro Arg Ala 
            980                 985                 990         


Leu Gln Arg His His Thr Ile Gln  Asn Ser Asp Asp Ala  Tyr Val Gln 
        995                 1000                 1005             


Leu Asp  Asn Leu Pro Gly Met  Ser Leu Val Ala Gly  Lys Ala Leu 
    1010                 1015                 1020             


Ser Ser  Ala Arg Met Ser Asp  Ala Val Leu Ser Gln  Ser Ser Leu 
    1025                 1030                 1035             


Met Gly  Ser Gln Gln Phe Gln  Asp Gly Glu Asn Glu  Glu Cys Gly 
    1040                 1045                 1050             


Ala Ser  Leu Gly Gly His Glu  His Pro Asp Leu Ser  Asp Gly Ser 
    1055                 1060                 1065             


Gln His  Leu Asn Ser Ser Cys  Tyr Pro Ser Thr Cys  Ile Thr Asp 
    1070                 1075                 1080             


Ile Leu  Leu Ser Tyr Lys His  Pro Glu Val Ser Phe  Ser Met Glu 
    1085                 1090                 1095             


Gln Ala  Gly Val 
    1100         


<210> 7690
<211> 486
<212> PRT
<213> Homo sapiens

<400> 7690
Met Thr Leu Met Val Leu Thr Phe Ser Ser Tyr Ile Leu Asp Phe Ile 
1               5                   10                  15      


Asn Val Leu Ser Tyr Asp Leu His Gly Ser Trp Glu Arg Phe Thr Gly 
            20                  25                  30          


His Asn Ser Pro Leu Phe Ser Leu Pro Glu Asp Pro Lys Ser Ser Ala 
        35                  40                  45              


Tyr Ala Met Asn Tyr Trp Arg Lys Leu Gly Ala Pro Ser Glu Lys Leu 
    50                  55                  60                  


Ile Met Gly Ile Pro Thr Tyr Gly Arg Thr Phe Arg Leu Leu Lys Ala 
65                  70                  75                  80  


Ser Lys Asn Gly Leu Gln Ala Arg Ala Ile Gly Pro Ala Ser Pro Gly 
                85                  90                  95      


Lys Tyr Thr Lys Gln Glu Gly Phe Leu Ala Tyr Phe Glu Ile Cys Ser 
            100                 105                 110         


Phe Val Trp Gly Ala Lys Lys His Trp Ile Asp Tyr Gln Tyr Val Pro 
        115                 120                 125             


Tyr Ala Asn Lys Gly Lys Glu Trp Val Gly Tyr Asp Asn Ala Ile Ser 
    130                 135                 140                 


Phe Ser Tyr Lys Ala Trp Phe Ile Arg Arg Glu His Phe Gly Gly Ala 
145                 150                 155                 160 


Met Val Trp Thr Leu Asp Met Asp Asp Val Arg Gly Thr Phe Cys Gly 
                165                 170                 175     


Thr Gly Pro Phe Pro Leu Val Tyr Val Leu Asn Asp Ile Leu Val Arg 
            180                 185                 190         


Ala Glu Phe Ser Ser Thr Ser Leu Pro Gln Phe Trp Leu Ser Ser Ala 
        195                 200                 205             


Val Asn Ser Ser Ser Thr Asp Pro Glu Arg Leu Ala Val Thr Thr Ala 
    210                 215                 220                 


Trp Thr Thr Asp Ser Lys Ile Leu Pro Pro Gly Gly Glu Ala Gly Val 
225                 230                 235                 240 


Thr Glu Ile His Gly Lys Cys Glu Asn Met Thr Ile Thr Pro Arg Gly 
                245                 250                 255     


Thr Thr Val Thr Pro Thr Lys Glu Thr Val Ser Leu Gly Lys His Thr 
            260                 265                 270         


Val Ala Leu Gly Glu Lys Thr Glu Ile Thr Gly Ala Met Thr Met Thr 
        275                 280                 285             


Ser Val Gly His Gln Ser Met Thr Pro Gly Glu Lys Ala Leu Thr Pro 
    290                 295                 300                 


Val Gly His Gln Ser Val Thr Thr Gly Gln Lys Thr Leu Thr Ser Val 
305                 310                 315                 320 


Gly Tyr Gln Ser Val Thr Pro Gly Glu Lys Thr Leu Thr Pro Val Gly 
                325                 330                 335     


His Gln Ser Val Thr Pro Val Ser His Gln Ser Val Ser Pro Gly Gly 
            340                 345                 350         


Thr Thr Met Thr Pro Val His Phe Gln Thr Glu Thr Leu Arg Gln Asn 
        355                 360                 365             


Thr Val Ala Pro Arg Arg Lys Ala Val Ala Arg Glu Lys Val Thr Val 
    370                 375                 380                 


Pro Ser Arg Asn Ile Ser Val Thr Pro Glu Gly Gln Thr Met Pro Leu 
385                 390                 395                 400 


Arg Gly Glu Asn Leu Thr Ser Glu Val Gly Thr His Pro Arg Met Gly 
                405                 410                 415     


Asn Leu Gly Leu Gln Met Glu Ala Glu Asn Arg Met Met Leu Ser Ser 
            420                 425                 430         


Ser Pro Val Ile Gln Leu Pro Glu Gln Thr Pro Leu Ala Phe Asp Asn 
        435                 440                 445             


Arg Phe Val Pro Ile Tyr Gly Asn His Ser Ser Val Asn Ser Val Thr 
    450                 455                 460                 


Pro Gln Thr Ser Pro Leu Ser Leu Lys Lys Glu Ile Pro Glu Asn Ser 
465                 470                 475                 480 


Ala Val Asp Glu Glu Ala 
                485     


<210> 7691
<211> 338
<212> PRT
<213> Homo sapiens

<400> 7691
Met Glu Leu Trp Gly Arg Met Leu Trp Ala Leu Leu Ser Gly Pro Gly 
1               5                   10                  15      


Arg Arg Gly Ser Thr Arg Gly Trp Ala Phe Ser Ser Trp Gln Pro Gln 
            20                  25                  30          


Pro Pro Leu Ala Gly Leu Ser Ser Ala Ile Glu Leu Val Ser His Trp 
        35                  40                  45              


Thr Gly Val Phe Glu Lys Arg Gly Ile Pro Glu Ala Arg Glu Ser Ser 
    50                  55                  60                  


Glu Tyr Ile Val Ala His Val Leu Gly Ala Lys Thr Phe Gln Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Leu Trp Thr Gln Pro Leu Thr Ser Gln Gln Leu Gln Cys 
                85                  90                  95      


Ile Arg Glu Leu Ser Ser Arg Arg Leu Gln Arg Met Pro Val Gln Tyr 
            100                 105                 110         


Ile Leu Gly Glu Trp Asp Phe Gln Gly Leu Ser Leu Arg Met Val Pro 
        115                 120                 125             


Pro Val Phe Ile Pro Arg Pro Glu Thr Glu Glu Leu Val Glu Trp Val 
    130                 135                 140                 


Leu Glu Glu Val Ala Gln Arg Ser His Ala Val Gly Ser Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Ile Leu Glu Val Gly Cys Gly Ser Gly Ala Ile Ser Leu Ser 
                165                 170                 175     


Leu Leu Ser Gln Leu Pro Gln Ser Arg Val Ile Ala Val Asp Lys Arg 
            180                 185                 190         


Glu Ala Ala Ile Ser Leu Thr His Glu Asn Ala Gln Arg Leu Arg Leu 
        195                 200                 205             


Gln Asp Arg Ile Trp Ile Ile His Leu Asp Met Thr Ser Glu Arg Ser 
    210                 215                 220                 


Trp Thr His Leu Pro Trp Gly Pro Met Asp Leu Ile Val Ser Asn Pro 
225                 230                 235                 240 


Pro Tyr Val Phe His Gln Asp Met Glu Gln Leu Ala Pro Glu Ile Arg 
                245                 250                 255     


Ser Tyr Glu Asp Pro Ala Ala Leu Asp Gly Gly Glu Glu Gly Met Asp 
            260                 265                 270         


Ile Ile Thr His Ile Leu Ala Leu Ala Pro Arg Leu Leu Lys Asp Ser 
        275                 280                 285             


Gly Ser Ile Phe Leu Glu Val Asp Pro Arg His Pro Glu Leu Val Ser 
    290                 295                 300                 


Ser Trp Leu Gln Ser Arg Pro Asp Leu Tyr Leu Asn Leu Val Ala Val 
305                 310                 315                 320 


Arg Arg Asp Phe Cys Gly Arg Pro Arg Phe Leu His Ile Arg Arg Ser 
                325                 330                 335     


Gly Pro 
        


<210> 7692
<211> 632
<212> PRT
<213> Homo sapiens

<400> 7692
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                165                 170                 175     


Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
            180                 185                 190         


Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
        195                 200                 205             


Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
    210                 215                 220                 


Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
225                 230                 235                 240 


Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                245                 250                 255     


Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
            260                 265                 270         


Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
        275                 280                 285             


Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys Gly 
    290                 295                 300                 


Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys Arg 
305                 310                 315                 320 


Val Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys Ile 
                325                 330                 335     


Pro Thr Leu Ile Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu Ala 
            340                 345                 350         


Asp Phe Val Ser Gln Thr Ser Pro Met Ile Pro Ser Ile Val Val His 
        355                 360                 365             


Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Thr Gly Leu Tyr 
    370                 375                 380                 


Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys Phe 
385                 390                 395                 400 


Leu Arg Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile His 
                405                 410                 415     


Ala Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu Pro 
            420                 425                 430         


Leu Leu Thr Phe Arg Leu Asn Arg Ala Phe Met Glu Ala Ala Glu Ile 
        435                 440                 445             


Thr Asp Glu Asp Asn Ser Ile Ala Ala Met Tyr Gln Ala Val Gly Glu 
    450                 455                 460                 


Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His Leu 
465                 470                 475                 480 


Gln Arg Val Ala Gln Ser Pro His Thr Lys Met Asp Val Ala Asn Leu 
                485                 490                 495     


Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Ala Val Pro Asn Pro 
            500                 505                 510         


Asp Pro Val Thr Met Leu Gln Asp Ile Lys Arg Gln Pro Lys Val Val 
        515                 520                 525             


Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Ser Gln Phe Met Met 
    530                 535                 540                 


Val Glu Gln Glu Asn Ile Asp Pro Leu His Val Ile Glu Asn Ser Asn 
545                 550                 555                 560 


Ala Phe Ser Thr Pro Gln Thr Pro Asp Ile Lys Val Ser Leu Leu Gly 
                565                 570                 575     


Pro Val Thr Thr Pro Glu His Gln Leu Leu Lys Thr Pro Ser Ser Ser 
            580                 585                 590         


Ser Leu Ser Gln Arg Val Arg Ser Thr Leu Thr Lys Asn Thr Pro Arg 
        595                 600                 605             


Phe Gly Ser Lys Ser Lys Ser Ala Thr Asn Leu Gly Arg Gln Gly Asn 
    610                 615                 620                 


Phe Phe Ala Ser Pro Met Leu Lys 
625                 630         


<210> 7693
<211> 596
<212> PRT
<213> Homo sapiens

<400> 7693
Met Ser Asn Gln Gln Glu Lys Tyr Glu Ala Gln Asn Ile Val Asn Ser 
1               5                   10                  15      


Thr Glu Glu Ser Asp Asp Ala Phe Asp Thr Val Thr Ile Pro Val Pro 
            20                  25                  30          


Ser Glu Glu Pro Gln Glu Ser Asp Gln Thr Glu Glu His Glu Ser Gly 
        35                  40                  45              


Ile Glu Gln Phe Ser Glu Ser His Ala Ile His Val Glu Glu Gln Ser 
    50                  55                  60                  


Asp Gln Ser Phe Ser Ser Leu Glu Pro Asp Asn Glu Gln Leu Met Glu 
65                  70                  75                  80  


Glu Val Ile Ser Pro Arg Gln Val Ser Tyr Thr Pro Gln His His Glu 
                85                  90                  95      


Lys Gln Tyr Ala Met Gln Arg Pro Asn Asp Asp Ser Leu Ala Phe Leu 
            100                 105                 110         


Asp Lys Ile Lys Ser Val Lys Glu Ser Leu Gln Glu Ser Val Glu Asp 
        115                 120                 125             


Ser Leu Ala Thr Val Lys Val Val Leu Ile Pro Val Gly Gln Glu Ile 
    130                 135                 140                 


Val Ile Pro Phe Lys Val Asp Thr Ile Leu Lys Tyr Leu Lys Asp His 
145                 150                 155                 160 


Phe Ser His Leu Leu Gly Ile Pro His Ser Val Leu Gln Ile Arg Tyr 
                165                 170                 175     


Ser Gly Lys Ile Leu Lys Asn Asn Glu Thr Leu Val Gln His Gly Val 
            180                 185                 190         


Lys Pro Gln Glu Ile Val Gln Val Glu Ile Phe Ser Thr Asn Pro Asp 
        195                 200                 205             


Leu Tyr Pro Val Arg Arg Ile Asp Gly Leu Thr Asp Val Ser Gln Ile 
    210                 215                 220                 


Ile Thr Val Thr Val Gln Thr Gly Leu Asp Gln Tyr Gln Gln Val Pro 
225                 230                 235                 240 


Val Glu Ile Val Lys Ser Asp Phe His Lys Pro Phe Leu Gly Gly Phe 
                245                 250                 255     


Arg His Lys Val Thr Gly Val Glu Tyr His Asn Ala Gly Thr Gln Thr 
            260                 265                 270         


Val Pro Lys Arg Ile Pro Glu Arg Leu Ser Ile Phe Cys Arg Asp Thr 
        275                 280                 285             


Gln Thr Val Phe Gln Lys Lys Asn Leu Gln Gln Thr Thr Asn Thr Thr 
    290                 295                 300                 


Ser Thr Gln Met Thr Asn Ile Gly Val Tyr Val Ser Asn Met Thr Asp 
305                 310                 315                 320 


Lys Leu Val Thr Pro Gly Lys Tyr Phe Ser Ala Ala Glu Tyr His Ala 
                325                 330                 335     


Gln Arg Leu Lys Ala Val Ile Val Ile Gln Thr Tyr Tyr Arg Gln Trp 
            340                 345                 350         


His Ala Lys Ile Phe Val Glu Asn Leu Arg Arg Gln Lys Ser Leu Arg 
        355                 360                 365             


Leu Glu Trp Glu Thr Gln Gln Glu Leu Arg Lys Ile Arg Glu Lys Glu 
    370                 375                 380                 


Glu Trp Ile Lys Leu Asp Tyr His Arg Arg His Asn Pro Lys Thr Asn 
385                 390                 395                 400 


Glu Asp Phe Glu Phe Leu Tyr Asn Ala Leu Glu Phe Trp Arg Gln Glu 
                405                 410                 415     


Glu Leu Thr Arg Ile Asn Gln Ser Phe Thr Gly Ala Glu Arg Lys Ala 
            420                 425                 430         


Ala Leu Cys Glu Leu Leu Glu Lys Glu Thr Gln Ile Ile Ala Ser Ile 
        435                 440                 445             


Gly Arg His Arg Tyr Ile Ala Tyr Met Ala Asn Gln Glu Ala Ala Ile 
    450                 455                 460                 


Gln Ala Phe Leu Asp Lys Cys Ser Ala Pro Lys Ile Trp Arg Thr Pro 
465                 470                 475                 480 


Asn Gly Lys Thr Ile Glu Met Asp Thr Gln Phe Thr Ile Arg Ala Arg 
                485                 490                 495     


Glu Leu Gln Asn Ile Tyr Lys Cys Ile Met Leu Lys Asn Ile Ser Gln 
            500                 505                 510         


Asp Glu Arg Leu Asp Val Leu Leu Thr Leu Lys His Thr Val Lys Glu 
        515                 520                 525             


His Glu Cys Lys Leu Thr Gln Glu Ile Leu Glu Leu Ile Asp Arg Glu 
    530                 535                 540                 


Val Asp Leu Met Met Arg Gly Val Lys His His Asn Leu Glu Gly Leu 
545                 550                 555                 560 


Arg Lys Arg Ile Ala Thr Leu Phe Phe His Tyr Ile Lys Thr Pro Leu 
                565                 570                 575     


Phe Asn Pro Glu Val Ala Lys Tyr Leu Lys Met Gly Gly Glu Tyr Leu 
            580                 585                 590         


Ser Met Ala Leu 
        595     


<210> 7694
<211> 434
<212> PRT
<213> Homo sapiens

<400> 7694
Met Val Gln Asp Gly Thr Phe Lys Thr Arg Asp Ser Thr Trp Thr Cys 
1               5                   10                  15      


Glu Ser Thr Arg Met Ala Ala Ala Pro Pro Ser Tyr Cys Phe Val Ala 
            20                  25                  30          


Phe Pro Pro Arg Ala Lys Asp Gly Leu Val Val Phe Gly Lys Asn Ser 
        35                  40                  45              


Ala Arg Pro Arg Asp Glu Val Gln Glu Val Val Tyr Phe Ser Ala Ala 
    50                  55                  60                  


Asp His Glu Pro Glu Ser Lys Val Glu Cys Thr Tyr Ile Ser Ile Asp 
65                  70                  75                  80  


Gln Val Pro Arg Thr Tyr Ala Ile Met Ile Ser Arg Pro Ala Trp Leu 
                85                  90                  95      


Trp Gly Ala Glu Met Gly Ala Asn Glu His Gly Val Cys Ile Ala Asn 
            100                 105                 110         


Glu Ala Ile Asn Thr Arg Glu Pro Ala Ala Glu Ile Glu Ala Leu Leu 
        115                 120                 125             


Gly Met Asp Leu Val Arg Leu Gly Leu Glu Arg Gly Glu Thr Ala Lys 
    130                 135                 140                 


Glu Ala Leu Asp Val Ile Val Ser Leu Leu Glu Glu His Gly Gln Gly 
145                 150                 155                 160 


Gly Asn Tyr Phe Glu Asp Ala Asn Ser Cys His Ser Phe Gln Ser Ala 
                165                 170                 175     


Tyr Leu Ile Val Asp Arg Asp Glu Ala Trp Val Leu Glu Thr Ile Gly 
            180                 185                 190         


Lys Tyr Trp Ala Ala Glu Lys Val Thr Glu Gly Val Arg Cys Ile Cys 
        195                 200                 205             


Ser Gln Leu Ser Leu Thr Thr Lys Met Asp Ala Glu His Pro Glu Leu 
    210                 215                 220                 


Arg Ser Tyr Ala Gln Ser Gln Gly Trp Trp Thr Gly Glu Gly Glu Phe 
225                 230                 235                 240 


Asn Phe Ser Glu Val Phe Ser Pro Val Glu Asp His Leu Asp Cys Gly 
                245                 250                 255     


Ala Gly Lys Asp Ser Leu Glu Lys Gln Glu Glu Ser Ile Thr Val Gln 
            260                 265                 270         


Thr Met Met Asn Thr Leu Arg Asp Lys Ala Ser Gly Val Cys Ile Asp 
        275                 280                 285             


Ser Glu Phe Phe Leu Thr Thr Ala Ser Gly Val Ser Val Leu Pro Gln 
    290                 295                 300                 


Asn Arg Ser Ser Pro Cys Ile His Tyr Phe Thr Gly Thr Pro Asp Pro 
305                 310                 315                 320 


Ser Arg Ser Ile Phe Lys Pro Phe Ile Phe Val Asp Asp Val Lys Leu 
                325                 330                 335     


Val Pro Lys Thr Gln Ser Pro Cys Phe Gly Asp Asp Asp Pro Ala Lys 
            340                 345                 350         


Lys Glu Pro Arg Phe Gln Glu Lys Pro Asp Arg Arg His Glu Leu Tyr 
        355                 360                 365             


Lys Ala His Glu Trp Ala Arg Ala Ile Ile Glu Ser Asp Gln Glu Gln 
    370                 375                 380                 


Gly Arg Lys Leu Arg Ser Thr Met Leu Glu Leu Glu Lys Gln Gly Leu 
385                 390                 395                 400 


Glu Ala Met Glu Glu Ile Leu Thr Ser Ser Glu Pro Leu Asp Pro Ala 
                405                 410                 415     


Glu Val Gly Asp Leu Phe Tyr Asp Cys Val Asp Thr Glu Ile Lys Phe 
            420                 425                 430         


Phe Lys 
        


<210> 7695
<211> 439
<212> PRT
<213> Homo sapiens

<400> 7695
Met Ala Trp Pro Cys Ile Thr Arg Ala Cys Cys Ile Ala Arg Phe Trp 
1               5                   10                  15      


Asn Gln Leu Asp Lys Ala Asp Ile Ala Val Pro Leu Val Phe Thr Lys 
            20                  25                  30          


Tyr Ser Glu Ala Thr Glu His Pro Gly Ala Pro Pro Gln Pro Pro Pro 
        35                  40                  45              


Pro Gln Gln Gln Ala Gln Pro Ala Leu Ala Pro Pro Ser Ala Arg Ala 
    50                  55                  60                  


Val Ala Ile Glu Thr Gln Pro Ala Gln Gly Glu Leu Asp Ala Val Ala 
65                  70                  75                  80  


Arg Ala Thr Gly Pro Ala Pro Gly Pro Thr Gly Glu Arg Glu Pro Ala 
                85                  90                  95      


Ala Gly Pro Gly Arg Ser Gly Pro Gly Pro Gly Leu Gly Ser Gly Ser 
            100                 105                 110         


Thr Ser Gly Pro Ala Asp Ser Val Met Arg Gln Asp Tyr Arg Ala Trp 
        115                 120                 125             


Lys Val Gln Arg Pro Glu Pro Ser Cys Arg Pro Arg Ser Glu Tyr Gln 
    130                 135                 140                 


Pro Ser Asp Ala Pro Phe Glu Arg Glu Thr Gln Tyr Gln Lys Asp Phe 
145                 150                 155                 160 


Arg Ala Trp Pro Leu Pro Arg Arg Gly Asp His Pro Trp Ile Pro Lys 
                165                 170                 175     


Pro Val Gln Ile Ser Ala Ala Ser Gln Ala Ser Ala Pro Ile Leu Gly 
            180                 185                 190         


Ala Pro Lys Arg Arg Pro Gln Ser Gln Glu Arg Trp Pro Val Gln Ala 
        195                 200                 205             


Ala Ala Glu Ala Arg Glu Gln Glu Ala Ala Pro Gly Gly Ala Gly Gly 
    210                 215                 220                 


Leu Ala Ala Gly Lys Ala Ser Gly Ala Asp Glu Arg Asp Thr Arg Arg 
225                 230                 235                 240 


Lys Ala Gly Pro Ala Trp Ile Val Arg Arg Ala Glu Gly Leu Gly His 
                245                 250                 255     


Glu Gln Thr Pro Leu Pro Ala Ala Gln Ala Gln Val Gln Ala Thr Gly 
            260                 265                 270         


Pro Glu Ala Gly Arg Gly Arg Ala Ala Ala Asp Ala Leu Asn Arg Gln 
        275                 280                 285             


Ile Arg Glu Glu Val Ala Ser Ala Val Ser Ser Ser Tyr Arg Asn Glu 
    290                 295                 300                 


Phe Arg Ala Trp Thr Asp Ile Lys Pro Val Lys Pro Ile Lys Ala Lys 
305                 310                 315                 320 


Pro Gln Tyr Lys Pro Pro Asp Asp Lys Met Val His Glu Thr Ser Tyr 
                325                 330                 335     


Ser Ala Gln Phe Lys Gly Glu Ala Ser Lys Pro Thr Thr Ala Asp Asn 
            340                 345                 350         


Lys Val Ile Asp Arg Arg Arg Ile Arg Ser Leu Tyr Ser Glu Pro Phe 
        355                 360                 365             


Lys Glu Pro Pro Lys Val Glu Lys Pro Ser Val Gln Ser Ser Lys Pro 
    370                 375                 380                 


Lys Lys Thr Ser Ala Ser His Lys Pro Thr Arg Lys Ala Lys Asp Lys 
385                 390                 395                 400 


Gln Ala Val Ser Gly Gln Ala Ala Lys Lys Lys Ser Ala Glu Gly Pro 
                405                 410                 415     


Ser Thr Thr Lys Pro Asp Asp Lys Glu Gln Ser Lys Glu Met Asn Asn 
            420                 425                 430         


Lys Leu Ala Glu Ala Lys Glu 
        435                 


<210> 7696
<211> 270
<212> PRT
<213> Homo sapiens

<400> 7696
Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu 
1               5                   10                  15      


Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser 
            20                  25                  30          


Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His 
        35                  40                  45              


Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro 
    50                  55                  60                  


Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn 
65                  70                  75                  80  


Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val 
                85                  90                  95      


Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr 
            100                 105                 110         


Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys 
        115                 120                 125             


Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp 
    130                 135                 140                 


Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys 
145                 150                 155                 160 


Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg 
                165                 170                 175     


Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser 
            180                 185                 190         


Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val 
        195                 200                 205             


Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu 
    210                 215                 220                 


Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys 
225                 230                 235                 240 


Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe 
                245                 250                 255     


Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val 
            260                 265                 270 


<210> 7697
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7697
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7698
<211> 422
<212> PRT
<213> Homo sapiens

<400> 7698
Met Thr Pro Ser Ile Pro Ser Ile Arg Arg Leu Gly Ser Gly Tyr Phe 
1               5                   10                  15      


Ser Ser Asn Gly Lys Leu Glu Glu Val Lys Thr Pro Lys Asn Pro Val 
            20                  25                  30          


Lys Arg Lys Asp Leu Leu Arg His Asp Pro Asp Leu His Met His Gln 
        35                  40                  45              


Gly Tyr Asp Lys Tyr Asp Val Ser Glu Phe Cys Ser Tyr Ile Lys Ser 
    50                  55                  60                  


Ser Ser Ser Leu Gly Asn Ala Thr Ser Asp Glu Asp Pro Asn Thr Asn 
65                  70                  75                  80  


Ile Met Asn Ile Asn Glu Asn Lys Asn Ile Pro Lys Ala Lys Asn Lys 
                85                  90                  95      


Ser Glu Ser Glu Asn Glu Pro Lys Ala Gly Thr Asp Ser Pro Val Ser 
            100                 105                 110         


Cys Ala Ser Val Thr Glu Glu Arg Val Ala Ser Asp Ser Pro Lys Pro 
        115                 120                 125             


Ala Leu Thr Leu Gln Gln Gly Gln Glu Phe Ser Ala Gly Gly Gln Asn 
    130                 135                 140                 


Ala Glu Asn Leu Cys Gln Phe Phe Lys Ile Ser Pro Asp Leu Asn Ile 
145                 150                 155                 160 


Lys Cys Glu Arg Lys Asp Asp Phe Leu Gly Ala Ala Glu Gly Lys Leu 
                165                 170                 175     


Gln Cys Asn Arg Leu Met Pro Asn Ser Gln Lys Asp Cys His Cys Leu 
            180                 185                 190         


Gly Asp Val Leu Ile Glu Asn Thr Lys Glu Ser Lys Ser Gln Ser Glu 
        195                 200                 205             


Asp Leu Gly Arg Lys Pro Met Glu Ser Ser Ser Val Val Ser Cys Arg 
    210                 215                 220                 


Asp Arg Lys Asp Arg Arg Arg Ser Met Cys Tyr Ser Asp Gly Arg Ser 
225                 230                 235                 240 


Leu His Leu Glu Lys Asn Gly Asn His Thr Pro Ser Ser Ser Val Gly 
                245                 250                 255     


Ser Ser Val Glu Ile Ser Leu Glu Asn Ser Glu Leu Phe Lys Asp Leu 
            260                 265                 270         


Ser Asp Ala Ile Glu Gln Thr Phe Gln Arg Arg Asn Ser Glu Thr Lys 
        275                 280                 285             


Val Arg Arg Ser Thr Arg Leu Gln Lys Asp Leu Glu Asn Glu Gly Leu 
    290                 295                 300                 


Val Trp Ile Ser Leu Pro Leu Pro Ser Thr Ser Gln Lys Ala Lys Arg 
305                 310                 315                 320 


Arg Thr Ile Cys Thr Phe Asp Ser Ser Gly Phe Glu Ser Met Ser Pro 
                325                 330                 335     


Ile Lys Glu Thr Val Ser Ser Arg Gln Lys Pro Gln Met Ala Pro Pro 
            340                 345                 350         


Val Ser Asp Pro Glu Asn Ser Gln Gly Pro Ala Ala Gly Ser Ser Asp 
        355                 360                 365             


Glu Pro Gly Lys Arg Arg Lys Ser Phe Cys Ile Ser Thr Leu Ala Asn 
    370                 375                 380                 


Thr Lys Ala Thr Ser Gln Phe Lys Gly Tyr Arg Arg Arg Ser Ser Leu 
385                 390                 395                 400 


Asn Gly Lys Gly Glu Ser Ser Leu Thr Ala Leu Glu Arg Ile Glu His 
                405                 410                 415     


Asn Gly Glu Arg Lys Gln 
            420         


<210> 7699
<211> 1111
<212> PRT
<213> Homo sapiens

<400> 7699
Met Val Arg Glu Arg Lys Cys Ile Leu Cys His Ile Val Tyr Ser Ser 
1               5                   10                  15      


Lys Lys Glu Met Asp Glu His Met Arg Ser Met Leu His His Arg Glu 
            20                  25                  30          


Leu Glu Asn Leu Lys Gly Arg Phe Gly Ile Glu Met Val Pro Leu Val 
        35                  40                  45              


Gln Asn Glu Gln Glu Ala Leu Asp Leu Asp Gly Glu Pro Asp Leu Ser 
    50                  55                  60                  


Ser Leu Glu Gly Phe Gln Trp Glu Gly Val Ser Ile Ser Ser Ser Pro 
65                  70                  75                  80  


Gly Leu Ala Arg Lys Arg Ser Leu Ser Glu Ser Ser Val Ile Met Asp 
                85                  90                  95      


Arg Ala Pro Ser Val Tyr Ser Phe Phe Ser Glu Glu Gly Thr Gly Lys 
            100                 105                 110         


Glu Asn Glu Pro Gln Gln Met Val Ser Pro Ser Asn Ser Leu Arg Ala 
        115                 120                 125             


Gly Gln Ser Gln Lys Ala Thr Met His Leu Lys Gln Glu Val Thr Pro 
    130                 135                 140                 


Arg Ala Ala Ser Leu Arg Thr Gly Glu Arg Ala Glu Asn Val Ala Thr 
145                 150                 155                 160 


Gln Arg Arg His Ser Ala Gln Leu Ser Ser Asp His Ile Ile Pro Leu 
                165                 170                 175     


Met His Leu Ala Lys Asp Leu Asn Ser Gln Glu Arg Ser Ile Pro Pro 
            180                 185                 190         


Ser Glu Asn Gln Asn Ser Gln Glu Ser Asn Gly Glu Gly Asn Cys Leu 
        195                 200                 205             


Ser Ser Ser Ala Ser Ser Ala Leu Ala Ile Ser Ser Leu Ala Asp Ala 
    210                 215                 220                 


Ala Thr Asp Ser Ser Cys Thr Ser Gly Ala Glu Gln Asn Asp Gly Gln 
225                 230                 235                 240 


Ser Ile Arg Lys Lys Arg Arg Ala Thr Gly Asp Gly Ser Ser Pro Glu 
                245                 250                 255     


Leu Pro Ser Leu Glu Arg Lys Asn Lys Arg Arg Lys Ile Lys Gly Lys 
            260                 265                 270         


Lys Glu Arg Ser Gln Val Asp Gln Leu Leu Asn Ile Ser Leu Arg Glu 
        275                 280                 285             


Glu Glu Leu Ser Lys Ser Leu Gln Cys Met Asp Asn Asn Leu Leu Gln 
    290                 295                 300                 


Ala Arg Ala Ala Leu Gln Thr Ala Tyr Val Glu Val Gln Arg Leu Leu 
305                 310                 315                 320 


Met Leu Lys Gln Gln Ile Thr Met Glu Met Ser Ala Leu Arg Thr His 
                325                 330                 335     


Arg Ile Gln Ile Leu Gln Gly Leu Gln Glu Thr Tyr Glu Pro Ser Glu 
            340                 345                 350         


His Pro Asp Gln Val Pro Cys Ser Leu Thr Arg Glu Arg Arg Asn Ser 
        355                 360                 365             


Arg Ser Gln Thr Ser Ile Asp Ala Ala Leu Leu Pro Thr Pro Phe Phe 
    370                 375                 380                 


Pro Leu Phe Leu Glu Pro Pro Ser Ser His Val Ser Pro Ser Pro Thr 
385                 390                 395                 400 


Gly Ala Ser Leu Gln Ile Thr Thr Ser Pro Thr Phe Gln Thr His Gly 
                405                 410                 415     


Ser Val Pro Ala Pro Asp Ser Ser Val Gln Ile Lys Gln Glu Pro Met 
            420                 425                 430         


Ser Pro Glu Gln Asp Glu Asn Val Asn Ala Val Pro Pro Ser Ser Ala 
        435                 440                 445             


Cys Asn Val Ser Lys Glu Leu Leu Glu Ala Asn Arg Glu Ile Ser Asp 
    450                 455                 460                 


Ser Cys Pro Val Tyr Pro Val Ile Thr Ala Arg Leu Ser Leu Pro Glu 
465                 470                 475                 480 


Ser Thr Glu Ser Phe His Glu Pro Ser Gln Glu Leu Lys Phe Ser Val 
                485                 490                 495     


Glu Gln Arg Asn Thr Arg Asn Arg Glu Asn Ser Pro Ser Ser Gln Ser 
            500                 505                 510         


Ala Gly Leu Ser Ser Ile Asn Lys Glu Gly Glu Glu Pro Thr Lys Gly 
        515                 520                 525             


Asn Ser Gly Ser Glu Ala Cys Thr Ser Ser Phe Leu Arg Leu Ser Phe 
    530                 535                 540                 


Ala Ser Glu Thr Pro Leu Glu Lys Glu Pro His Ser Pro Ala Asp Gln 
545                 550                 555                 560 


Pro Glu Gln Gln Ala Glu Ser Thr Leu Thr Ser Ala Glu Thr Arg Gly 
                565                 570                 575     


Ser Lys Lys Lys Lys Lys Leu Arg Lys Lys Lys Ser Leu Arg Ala Ala 
            580                 585                 590         


His Val Pro Glu Asn Ser Asp Thr Glu Gln Asp Val Leu Thr Val Lys 
        595                 600                 605             


Pro Val Arg Lys Val Lys Ala Gly Lys Leu Ile Lys Gly Gly Lys Val 
    610                 615                 620                 


Thr Thr Ser Thr Trp Glu Asp Ser Arg Thr Gly Arg Glu Gln Glu Ser 
625                 630                 635                 640 


Val Arg Asp Glu Pro Asp Ser Asp Ser Ser Leu Glu Val Leu Glu Ile 
                645                 650                 655     


Pro Asn Pro Gln Leu Glu Val Val Ala Ile Asp Ser Ser Glu Ser Gly 
            660                 665                 670         


Glu Glu Lys Pro Asp Ser Pro Ser Lys Lys Asp Ile Trp Asn Ser Thr 
        675                 680                 685             


Glu Gln Asn Pro Leu Glu Thr Ser Arg Ser Gly Cys Asp Glu Val Ser 
    690                 695                 700                 


Ser Thr Ser Glu Ile Gly Thr Arg Tyr Lys Asp Gly Ile Pro Val Ser 
705                 710                 715                 720 


Val Ala Glu Thr Gln Thr Val Ile Ser Ser Ile Lys Gly Ser Lys Asn 
                725                 730                 735     


Ser Ser Glu Ile Ser Ser Glu Pro Gly Asp Asp Asp Glu Pro Thr Glu 
            740                 745                 750         


Gly Ser Phe Glu Gly His Gln Ala Ala Val Asn Ala Ile Gln Ile Phe 
        755                 760                 765             


Gly Asn Leu Leu Tyr Thr Cys Ser Ala Asp Lys Thr Val Arg Val Tyr 
    770                 775                 780                 


Asn Leu Val Ser Arg Lys Cys Ile Gly Val Phe Glu Gly His Thr Ser 
785                 790                 795                 800 


Lys Val Asn Cys Leu Leu Val Thr Gln Thr Ser Gly Lys Asn Ala Ala 
                805                 810                 815     


Leu Tyr Thr Gly Ser Ser Asp His Thr Ile Arg Cys Tyr Asn Val Lys 
            820                 825                 830         


Ser Arg Glu Cys Val Glu Gln Leu Gln Leu Glu Asp Arg Val Leu Cys 
        835                 840                 845             


Leu His Ser Arg Trp Arg Ile Leu Tyr Ala Gly Leu Ala Asn Gly Thr 
    850                 855                 860                 


Val Val Thr Phe Asn Ile Lys Asn Asn Lys Arg Leu Glu Ile Phe Glu 
865                 870                 875                 880 


Cys His Gly Pro Arg Ala Val Ser Cys Leu Ala Thr Ala Gln Glu Gly 
                885                 890                 895     


Ala Arg Lys Leu Leu Val Val Gly Ser Tyr Asp Cys Thr Ile Ser Val 
            900                 905                 910         


Arg Asp Ala Arg Asn Gly Leu Leu Leu Arg Thr Leu Glu Gly His Ser 
        915                 920                 925             


Lys Thr Ile Leu Cys Met Lys Val Val Asn Asp Leu Val Phe Ser Gly 
    930                 935                 940                 


Ser Ser Asp Gln Ser Val His Ala His Asn Ile His Thr Gly Glu Leu 
945                 950                 955                 960 


Val Arg Ile Tyr Lys Gly His Asn His Ala Val Thr Val Val Asn Ile 
                965                 970                 975     


Leu Gly Lys Val Met Val Thr Ala Cys Leu Asp Lys Phe Val Arg Val 
            980                 985                 990         


Tyr Glu Leu Gln Ser His Asp Arg  Leu Gln Val Tyr Gly  Gly His Lys 
        995                 1000                 1005             


Asp Met  Ile Met Cys Met Thr  Ile His Lys Ser Met  Ile Tyr Thr 
    1010                 1015                 1020             


Gly Cys  Tyr Asp Gly Ser Ile  Gln Ala Val Arg Leu  Asn Leu Met 
    1025                 1030                 1035             


Gln Asn  Tyr Arg Cys Trp Trp  His Gly Cys Ser Leu  Ile Phe Gly 
    1040                 1045                 1050             


Val Val  Asp His Leu Lys Gln  His Leu Leu Thr Asp  His Thr Asn 
    1055                 1060                 1065             


Pro Asn  Phe Gln Thr Leu Lys  Cys Arg Trp Lys Asn  Cys Asp Ala 
    1070                 1075                 1080             


Phe Phe  Thr Ala Arg Lys Gly  Ser Lys Gln Asp Ala  Ala Gly His 
    1085                 1090                 1095             


Ile Glu  Arg His Ala Glu Asp  Asp Ser Lys Ile Asp  Ser 
    1100                 1105                 1110     


<210> 7700
<211> 117
<212> PRT
<213> Homo sapiens

<400> 7700
Met Tyr Ser Pro Ile Ile Tyr Gln Ala Leu Cys Glu His Val Gln Thr 
1               5                   10                  15      


Gln Met Ser Leu Met Asn Asp Leu Thr Ser Lys Asn Ile Pro Asn Gly 
            20                  25                  30          


Ile Pro Ala Val Pro Cys His Ala Pro Ser His Ser Glu Ser Gln Ala 
        35                  40                  45              


Thr Pro His Ser Ser Tyr Gly Leu Cys Thr Ser Thr Pro Val Trp Ser 
    50                  55                  60                  


Leu Gln Arg Pro Pro Cys Pro Pro Lys Val His Ser Glu Val Gln Thr 
65                  70                  75                  80  


Asp Gly Asn Ser Gln Phe Ala Ser Gln Gly Lys Thr Val Ser Ala Thr 
                85                  90                  95      


Cys Thr Asp Val Leu Arg Asn Ser Phe Asn Thr Ser Pro Gly Val Pro 
            100                 105                 110         


Cys Ser Leu Pro Lys 
        115         


<210> 7701
<211> 62
<212> PRT
<213> Homo sapiens

<400> 7701
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser 
    50                  55                  60          


<210> 7702
<211> 136
<212> PRT
<213> Homo sapiens

<400> 7702
Met Ser Ala Ser Cys Asp Gly Cys Val Gly Ser Arg Pro Pro Val His 
1               5                   10                  15      


Leu Ala Ser Gly Tyr Ser Leu Ala Asp Leu Leu Val Leu Glu Met Gly 
            20                  25                  30          


Met Gly Thr Gln Cys Trp Thr Glu Asp Gln Arg Arg Trp Ser Ser Leu 
        35                  40                  45              


Trp Pro Trp Ser His Leu Ser Ser Val Leu Leu Ala Asp Lys Glu Gly 
    50                  55                  60                  


Gly Pro Pro Ala Val Asp Glu Val Leu Asp Glu Ala Val Pro Glu Tyr 
65                  70                  75                  80  


Arg Ala Pro Gly Arg Lys Ser Leu Leu Glu Ile Arg Gln Leu Asp Pro 
                85                  90                  95      


Asp Asp Arg Ser Leu Ala Lys Tyr Lys Arg Val Leu Leu Gly Pro Leu 
            100                 105                 110         


Pro Pro Ala Val Asp Pro Ser Leu Pro Asn Val Gln Val Thr Arg Leu 
        115                 120                 125             


Thr Leu Leu Ser Glu Gln Ala Pro 
    130                 135     


<210> 7703
<211> 600
<212> PRT
<213> Homo sapiens

<400> 7703
Met Pro Glu Ile Arg Val Thr Pro Leu Gly Ala Gly Gln Asp Val Gly 
1               5                   10                  15      


Arg Ser Cys Ile Leu Val Ser Ile Ala Gly Lys Asn Val Met Leu Asp 
            20                  25                  30          


Cys Gly Met His Met Gly Phe Asn Asp Asp Arg Arg Phe Pro Asp Phe 
        35                  40                  45              


Ser Tyr Ile Thr Gln Asn Gly Arg Leu Thr Asp Phe Leu Asp Cys Val 
    50                  55                  60                  


Ile Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu Pro Tyr Phe 
65                  70                  75                  80  


Ser Glu Met Val Gly Tyr Asp Gly Pro Ile Tyr Met Thr His Pro Thr 
                85                  90                  95      


Gln Ala Ile Cys Pro Ile Leu Leu Glu Asp Tyr Arg Lys Ile Ala Val 
            100                 105                 110         


Asp Lys Lys Gly Glu Ala Asn Phe Phe Thr Ser Gln Met Ile Lys Asp 
        115                 120                 125             


Cys Met Lys Lys Val Val Ala Val His Leu His Gln Thr Val Gln Val 
    130                 135                 140                 


Asp Asp Glu Leu Glu Ile Lys Ala Tyr Tyr Ala Gly His Val Leu Gly 
145                 150                 155                 160 


Ala Ala Met Phe Gln Ile Lys Val Gly Ser Glu Ser Val Val Tyr Thr 
                165                 170                 175     


Gly Asp Tyr Asn Met Thr Pro Asp Arg His Leu Gly Ala Ala Trp Ile 
            180                 185                 190         


Asp Lys Cys Arg Pro Asn Leu Leu Ile Thr Glu Ser Thr Tyr Ala Thr 
        195                 200                 205             


Thr Ile Arg Asp Ser Lys Arg Cys Arg Glu Arg Asp Phe Leu Lys Lys 
    210                 215                 220                 


Val His Glu Thr Val Glu Arg Gly Gly Lys Val Leu Ile Pro Val Phe 
225                 230                 235                 240 


Ala Leu Gly Arg Ala Gln Glu Leu Cys Ile Leu Leu Glu Thr Phe Trp 
                245                 250                 255     


Glu Arg Met Asn Leu Lys Val Pro Ile Tyr Phe Ser Thr Gly Leu Thr 
            260                 265                 270         


Glu Lys Ala Asn His Tyr Tyr Lys Leu Phe Ile Pro Trp Thr Asn Gln 
        275                 280                 285             


Lys Ile Arg Lys Thr Phe Val Gln Arg Asn Met Phe Glu Phe Lys His 
    290                 295                 300                 


Ile Lys Ala Phe Asp Arg Ala Phe Ala Asp Asn Pro Gly Pro Met Val 
305                 310                 315                 320 


Val Phe Ala Thr Pro Gly Met Leu His Ala Gly Gln Ser Leu Gln Ile 
                325                 330                 335     


Phe Arg Lys Trp Ala Gly Asn Glu Lys Asn Met Val Ile Met Pro Gly 
            340                 345                 350         


Tyr Cys Val Gln Gly Thr Val Gly His Lys Ile Leu Ser Gly Gln Arg 
        355                 360                 365             


Lys Leu Glu Met Glu Gly Arg Gln Val Leu Glu Val Lys Met Gln Val 
    370                 375                 380                 


Glu Tyr Met Ser Phe Ser Ala His Ala Asp Ala Lys Gly Ile Met Gln 
385                 390                 395                 400 


Leu Val Gly Gln Ala Glu Pro Glu Ser Val Leu Leu Val His Gly Glu 
                405                 410                 415     


Ala Lys Lys Met Glu Phe Leu Lys Gln Lys Ile Glu Gln Glu Leu Arg 
            420                 425                 430         


Val Asn Cys Tyr Met Pro Ala Asn Gly Glu Thr Val Thr Leu Pro Thr 
        435                 440                 445             


Ser Pro Ser Ile Pro Val Gly Ile Ser Leu Gly Leu Leu Lys Arg Glu 
    450                 455                 460                 


Met Ala Gln Gly Leu Leu Pro Glu Ala Lys Lys Pro Arg Leu Leu His 
465                 470                 475                 480 


Gly Thr Leu Ile Met Lys Asp Ser Asn Phe Arg Leu Val Ser Ser Glu 
                485                 490                 495     


Gln Ala Leu Lys Glu Leu Gly Leu Ala Glu His Gln Leu Arg Phe Thr 
            500                 505                 510         


Cys Arg Val His Leu His Asp Thr Arg Lys Glu Gln Glu Thr Ala Leu 
        515                 520                 525             


Arg Val Tyr Ser His Leu Lys Ser Val Leu Lys Asp His Cys Val Gln 
    530                 535                 540                 


His Leu Pro Asp Gly Ser Val Thr Val Glu Ser Val Leu Leu Gln Ala 
545                 550                 555                 560 


Ala Ala Pro Ser Glu Asp Pro Gly Thr Lys Val Leu Leu Val Ser Trp 
                565                 570                 575     


Thr Tyr Gln Asp Glu Glu Leu Gly Ser Phe Leu Thr Ser Leu Leu Lys 
            580                 585                 590         


Lys Gly Leu Pro Gln Ala Pro Ser 
        595                 600 


<210> 7704
<211> 257
<212> PRT
<213> Homo sapiens

<400> 7704
Met Leu Glu Tyr Ala Leu Lys Gln Glu Arg Ala Lys Tyr His Lys Leu 
1               5                   10                  15      


Lys Phe Gly Thr Asp Leu Asn Gln Gly Glu Lys Lys Ala Asp Val Ser 
            20                  25                  30          


Glu Gln Val Ser Asn Gly Pro Val Glu Ser Val Thr Leu Glu Asn Ser 
        35                  40                  45              


Pro Leu Val Trp Lys Glu Gly Arg Gln Leu Leu Arg Gln Tyr Leu Glu 
    50                  55                  60                  


Glu Val Gly Tyr Thr Asp Thr Ile Leu Asp Met Arg Ser Lys Arg Val 
65                  70                  75                  80  


Arg Ser Leu Leu Gly Arg Ser Leu Glu Leu Asn Gly Ala Val Glu Pro 
                85                  90                  95      


Ser Glu Gly Ala Pro Arg Ala Pro Pro Gly Pro Ala Gly Leu Ser Gly 
            100                 105                 110         


Gly Glu Ser Leu Leu Val Lys Gln Ile Glu Glu Gln Ile Lys Arg Asn 
        115                 120                 125             


Ala Ala Gly Lys Asp Gly Lys Glu Arg Leu Gly Gly Ser Val Leu Gly 
    130                 135                 140                 


Gln Ile Pro Phe Leu Gln Asn Cys Glu Asp Glu Asp Ser Asp Glu Asp 
145                 150                 155                 160 


Asp Glu Leu Asp Ser Val Gln His Lys Lys Gln Arg Val Lys Leu Pro 
                165                 170                 175     


Ser Lys Ala Leu Val Pro Glu Met Glu Asp Glu Asp Glu Glu Asp Asp 
            180                 185                 190         


Ser Glu Asp Ala Ile Asn Glu Phe Asp Phe Leu Gly Ser Gly Glu Asp 
        195                 200                 205             


Gly Glu Gly Ala Pro Asp Pro Arg Arg Cys Thr Val Asp Gly Ser Pro 
    210                 215                 220                 


His Glu Leu Gly Pro Glu Leu His Ser Pro Thr Glu Trp Gln Gly Ala 
225                 230                 235                 240 


Leu Ser Val Gly Lys Ala Ser Pro Met Pro Asp Trp Val Gly Thr Ala 
                245                 250                 255     


Gly 
    


<210> 7705
<211> 126
<212> PRT
<213> Homo sapiens

<400> 7705
Met Pro Gly Val Lys Leu Thr Thr Gln Ala Tyr Cys Lys Met Val Leu 
1               5                   10                  15      


His Gly Ala Lys Tyr Pro His Cys Ala Val Asn Gly Leu Leu Val Ala 
            20                  25                  30          


Glu Lys Gln Lys Pro Arg Lys Glu His Leu Pro Leu Gly Gly Pro Gly 
        35                  40                  45              


Ala His His Thr Leu Phe Val Asp Cys Ile Pro Leu Phe His Gly Thr 
    50                  55                  60                  


Leu Ala Leu Ala Pro Met Leu Glu Val Ala Leu Thr Leu Ile Asp Ser 
65                  70                  75                  80  


Trp Cys Lys Asp His Ser Tyr Val Ile Ala Gly Tyr Tyr Gln Ala Asn 
                85                  90                  95      


Glu Arg Val Lys Asp Ala Ser Pro Asn Gln Val Ala Glu Lys Val Ala 
            100                 105                 110         


Ser Arg Ile Ala Glu Gly Phe Ser Asp Thr Ala Leu Ile Met 
        115                 120                 125     


<210> 7706
<211> 149
<212> PRT
<213> Homo sapiens

<400> 7706
Val Arg Glu Leu Glu Ala Glu Leu Asp Ala Glu Gln Lys Lys His Ala 
1               5                   10                  15      


Glu Ala Leu Lys Gly Val Arg Lys His Glu Arg Arg Val Lys Glu Leu 
            20                  25                  30          


Ala Tyr Gln Val Gly Asp Arg Val Ser Leu Gly Ser Gly Pro Gly Ala 
        35                  40                  45              


Gly Pro Ala Gln Ala Ser Pro Glu Ser Pro Leu Pro Ala Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Lys Asn Leu Ala Arg Met Gln Asp Leu Val Asp Lys Leu 
65                  70                  75                  80  


Gln Ser Lys Val Lys Ser Tyr Lys Arg Gln Phe Glu Glu Ala Glu Gln 
                85                  90                  95      


Gln Ala Asn Thr Asn Leu Ala Lys Tyr Arg Lys Ala Gln His Glu Leu 
            100                 105                 110         


Asp Asp Ala Glu Glu Arg Ala Asp Met Ala Glu Thr Gln Ala Asn Lys 
        115                 120                 125             


Leu Arg Ala Arg Thr Arg Asp Ala Leu Gly Pro Lys Leu Ser Leu Ser 
    130                 135                 140                 


Pro Gln His Lys Glu 
145                 


<210> 7707
<211> 782
<212> PRT
<213> Homo sapiens

<400> 7707
Met Asp Ser Ser Ile His Leu Ser Ser Leu Ile Ser Arg His Asp Asp 
1               5                   10                  15      


Glu Ala Thr Arg Thr Ser Thr Ser Glu Gly Leu Glu Glu Gly Glu Val 
            20                  25                  30          


Glu Gly Glu Thr Leu Leu Ile Val Glu Ser Glu Asp Gln Ala Ser Val 
        35                  40                  45              


Asp Leu Ser His Asp Gln Ser Gly Asp Ser Leu Asn Ser Asp Glu Gly 
    50                  55                  60                  


Asp Val Ser Trp Met Glu Glu Gln Leu Ser Tyr Phe Cys Asp Lys Cys 
65                  70                  75                  80  


Gln Lys Trp Ile Pro Ala Ser Gln Leu Arg Glu Gln Leu Ser Tyr Leu 
                85                  90                  95      


Lys Gly Asp Asn Phe Phe Arg Phe Thr Cys Ser Asp Cys Ser Ala Asp 
            100                 105                 110         


Gly Lys Glu Gln Tyr Glu Arg Leu Lys Leu Thr Trp Gln Gln Val Val 
        115                 120                 125             


Met Leu Ala Met Tyr Asn Leu Ser Leu Glu Gly Ser Gly Arg Gln Gly 
    130                 135                 140                 


Tyr Phe Arg Trp Lys Glu Asp Ile Cys Ala Phe Ile Glu Lys His Trp 
145                 150                 155                 160 


Thr Phe Leu Leu Gly Asn Arg Lys Lys Thr Ser Thr Trp Trp Ser Thr 
                165                 170                 175     


Val Ala Gly Cys Leu Ser Val Gly Ser Pro Met Tyr Phe Arg Ser Gly 
            180                 185                 190         


Ala Gln Glu Phe Gly Glu Pro Gly Trp Trp Lys Leu Val His Asn Lys 
        195                 200                 205             


Pro Pro Thr Met Lys Pro Glu Gly Glu Lys Leu Ser Ala Ser Thr Leu 
    210                 215                 220                 


Lys Ile Lys Ala Ala Ser Lys Pro Thr Leu Asp Pro Ile Ile Thr Val 
225                 230                 235                 240 


Glu Gly Leu Arg Lys Arg Ala Ser Arg Asn Pro Val Glu Ser Ala Met 
                245                 250                 255     


Glu Leu Lys Glu Lys Arg Ser Arg Thr Gln Glu Ala Lys Asp Ile Arg 
            260                 265                 270         


Arg Ala Gln Lys Glu Ala Ala Gly Phe Leu Asp Arg Ser Thr Ser Ser 
        275                 280                 285             


Thr Pro Val Lys Phe Ile Ser Arg Gly Arg Arg Pro Asp Val Ile Leu 
    290                 295                 300                 


Glu Lys Gly Glu Val Ile Asp Phe Ser Ser Leu Ser Ser Ser Asp Arg 
305                 310                 315                 320 


Thr Pro Leu Thr Ser Pro Ser Pro Ser Pro Ser Leu Asp Phe Ser Ala 
                325                 330                 335     


Pro Gly Thr Pro Ala Ser His Ser Ala Thr Pro Ser Leu Leu Ser Glu 
            340                 345                 350         


Ala Asp Leu Ile Pro Asp Val Met Pro Pro Gln Ala Leu Phe His Asp 
        355                 360                 365             


Asp Asp Glu Met Glu Gly Asp Gly Val Ile Asp Pro Gly Met Glu Tyr 
    370                 375                 380                 


Val Pro Pro Pro Ala Gly Ser Val Ala Ser Gly Pro Val Val Gly Val 
385                 390                 395                 400 


Arg Lys Lys Val Arg Gly Pro Glu Gln Ile Lys Gln Glu Val Glu Ser 
                405                 410                 415     


Glu Glu Glu Lys Pro Asp Arg Met Asp Ile Asp Ser Glu Asp Thr Asp 
            420                 425                 430         


Ser Asn Thr Ser Leu Gln Thr Arg Ala Arg Glu Lys Arg Lys Pro Gln 
        435                 440                 445             


Leu Glu Lys Asp Thr Lys Pro Lys Glu Pro Arg Tyr Thr Pro Val Ser 
    450                 455                 460                 


Ile Tyr Glu Glu Lys Leu Leu Leu Lys Arg Leu Glu Ala Cys Pro Gly 
465                 470                 475                 480 


Ala Val Ala Met Thr Pro Glu Ala Arg Arg Leu Lys Arg Lys Leu Ile 
                485                 490                 495     


Val Arg Gln Ala Lys Arg Asp Arg Gly Leu Pro Leu Phe Asp Leu Asp 
            500                 505                 510         


Gln Val Val Asn Ala Ala Leu Leu Leu Val Asp Gly Ile Tyr Gly Ala 
        515                 520                 525             


Lys Glu Gly Gly Ile Ser Arg Leu Pro Ala Gly Gln Ala Thr Tyr Arg 
    530                 535                 540                 


Thr Thr Cys Gln Asp Phe Arg Ile Leu Asp Arg Tyr Gln Thr Ser Leu 
545                 550                 555                 560 


Pro Ser Arg Lys Gly Phe Arg His Gln Thr Thr Lys Phe Leu Tyr Arg 
                565                 570                 575     


Leu Val Gly Ser Glu Asp Met Ala Val Asp Gln Ser Ile Val Ser Pro 
            580                 585                 590         


Tyr Thr Ser Arg Ile Leu Lys Pro Tyr Ile Arg Arg Asp Tyr Glu Thr 
        595                 600                 605             


Lys Pro Pro Lys Leu Gln Leu Leu Ser Gln Ile Arg Ser His Leu His 
    610                 615                 620                 


Arg Ser Asp Pro His Trp Thr Pro Glu Pro Asp Ala Pro Leu Asp Tyr 
625                 630                 635                 640 


Cys Tyr Val Arg Pro Asn His Ile Pro Thr Ile Asn Ser Met Cys Gln 
                645                 650                 655     


Glu Phe Phe Trp Pro Gly Ile Asp Leu Ser Glu Cys Leu Gln Tyr Pro 
            660                 665                 670         


Asp Phe Ser Val Val Val Leu Tyr Lys Lys Val Ile Ile Ala Phe Gly 
        675                 680                 685             


Phe Met Val Pro Asp Val Lys Tyr Asn Glu Ala Tyr Ile Ser Phe Leu 
    690                 695                 700                 


Phe Val His Pro Glu Trp Arg Arg Ala Gly Ile Ala Thr Phe Met Ile 
705                 710                 715                 720 


Tyr His Leu Ile Gln Thr Cys Met Gly Lys Asp Val Thr Leu His Val 
                725                 730                 735     


Ser Ala Ser Asn Pro Ala Met Leu Leu Tyr Gln Lys Phe Gly Phe Lys 
            740                 745                 750         


Thr Glu Glu Tyr Val Leu Asp Phe Tyr Asp Lys Tyr Tyr Pro Leu Glu 
        755                 760                 765             


Ser Thr Glu Cys Lys His Ala Phe Phe Leu Arg Leu Arg Arg 
    770                 775                 780         


<210> 7708
<211> 164
<212> PRT
<213> Homo sapiens

<400> 7708
Met Met Ser Glu Val Glu Glu Ala Met Gln Cys Val Glu Glu Leu Asn 
1               5                   10                  15      


Ala Gln Gly Leu Leu His Val Phe Val Arg Val Gly Val Glu Ser Thr 
            20                  25                  30          


Leu Glu Arg Ser Gln Ile Thr Arg Asp His Met Gly Gln Leu Leu Tyr 
        35                  40                  45              


Gln Leu Val Gln Ser Glu Lys Leu Ser Lys Gln Asp Phe Phe Lys Gly 
    50                  55                  60                  


Phe Ser Glu Thr Leu Glu Leu Ala Asp Asp Met Ala Ile Asp Ile Pro 
65                  70                  75                  80  


His Ile Trp Leu Tyr Leu Ala Glu Leu Val Thr Pro Met Leu Lys Glu 
                85                  90                  95      


Gly Gly Ile Ser Met Arg Glu Leu Thr Ile Glu Phe Ser Lys Pro Leu 
            100                 105                 110         


Leu Pro Val Gly Arg Ala Gly Val Leu Leu Ser Glu Ile Leu His Leu 
        115                 120                 125             


Leu Cys Lys Gln Met Ser His Lys Lys Val Gly Ala Leu Trp Arg Glu 
    130                 135                 140                 


Ala Asp Leu Ser Trp Lys Asp Phe Leu Pro Glu Gly Glu Asp Val His 
145                 150                 155                 160 


Asn Phe Leu Leu 
                


<210> 7709
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7709
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7710
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 7710
Met Ala Cys Arg Arg Arg Tyr Phe Val Glu Gly Glu Ala Pro Ser Ser 
1               5                   10                  15      


Glu Thr Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro 
            20                  25                  30          


Leu Val Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser 
        35                  40                  45              


Val Gly Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg 
    50                  55                  60                  


Thr Arg Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln 
65                  70                  75                  80  


Ala Glu Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr 
                85                  90                  95      


Glu Leu Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg 
            100                 105                 110         


Lys Tyr Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln 
        115                 120                 125             


Thr Ala Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg 
    130                 135                 140                 


Ser Ser Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn 
145                 150                 155                 160 


Met Arg Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser 
                165                 170                 175     


Tyr Phe Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu 
            180                 185                 190         


Gly Ala Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr 
        195                 200                 205             


Leu Lys Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu 
    210                 215                 220                 


Leu Glu Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile 
225                 230                 235                 240 


Asp Asp Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala 
                245                 250                 255     


Leu Asp Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His 
            260                 265                 270         


Gly Met Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp 
        275                 280                 285             


Val Thr Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu 
    290                 295                 300                 


Ser Gln Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu 
305                 310                 315                 320 


Arg Ala Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu 
                325                 330                 335     


Asp Lys Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu 
            340                 345                 350         


Arg Gln Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile 
        355                 360                 365             


Glu Pro Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg 
    370                 375                 380                 


Gly Ser Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln 
385                 390                 395                 400 


Gln Gly Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu 
                405                 410                 415     


Pro Arg Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp 
            420                 425                 430         


Ser His Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu 
        435                 440                 445             


Ser Asp Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn 
    450                 455                 460                 


Ser Asn Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser 
465                 470                 475                 480 


Leu Arg Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg 
                485                 490                 495     


Asn Ser Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg 
            500                 505                 510         


His Tyr Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly 
        515                 520                 525             


Val Gln Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly 
    530                 535                 540                 


Val Ala His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile 
545                 550                 555                 560 


Gly Glu Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu 
                565                 570                 575     


Asp Cys Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu 
            580                 585                 590         


Ala Leu Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln 
        595                 600                 605             


Lys Val Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys 
    610                 615                 620                 


Asn Pro Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile 
625                 630                 635                 640 


Leu Ala Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn 
                645                 650                 655     


Val Lys Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu 
            660                 665                 670         


Arg Gly Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly 
        675                 680                 685             


Ile Tyr Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His 
    690                 695                 700                 


Val Ser Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro 
705                 710                 715                 720 


Ile Gly Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His 
                725                 730                 735     


Arg Arg Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn 
            740                 745                 750         


Lys Pro Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn 
        755                 760                 765             


Asp Leu Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val 
    770                 775                 780                 


Thr Tyr Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu 
785                 790                 795                 800 


Leu Phe Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser 
                805                 810                 815     


Val Pro Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn 
            820                 825                 830         


Pro Gln Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala 
        835                 840                 845             


Glu Val Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys 
    850                 855                 860                 


Gln Lys Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys 
865                 870                 875                 880 


Lys Glu Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser 
                885                 890                 895     


Tyr Ala Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu 
            900                 905                 910         


Arg Asp Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg Ser Ser Ala Gly 
        915                 920                 925             


Ser Leu Glu Ser Asn Val Glu Gly Ser Ile Ile Ser Ser Pro His Met 
    930                 935                 940                 


Arg Arg Arg Ala Thr Ser Thr Arg Glu Cys Pro Ser Arg Pro His Gln 
945                 950                 955                 960 


Thr Met Pro Asn Ser Ser Ser Leu Leu Gly Ser Leu Phe Gly Ser Lys 
                965                 970                 975     


Arg Gly Lys Pro Pro Pro Gln Ala His Leu Pro Ser Ala Pro Ala Leu 
            980                 985                 990         


Pro Pro Pro His Pro Pro Val Val  Leu Pro His Leu Gln  His Ser Val 
        995                 1000                 1005             


Ala Gly  His His Leu Gly Pro  Pro Glu Gly Leu Pro  Gln Ala Ala 
    1010                 1015                 1020             


Met His  Gly His His Thr Gln  Tyr Cys His Met Gln  Asn Pro Pro 
    1025                 1030                 1035             


Pro Tyr  His His His His His  His His Pro Pro Gln  His Ile Gln 
    1040                 1045                 1050             


His Ala  His Gln Tyr His His  Gly Pro His Gly Gly  His Pro Ala 
    1055                 1060                 1065             


Tyr Gly  Ala His Ala His Gly  His Pro Pro Leu Pro  Ser Ala His 
    1070                 1075                 1080             


Val Gly  His Thr Val His His  His Gly Gln Pro Pro  Ala Pro Pro 
    1085                 1090                 1095             


Pro Pro  Thr Ser Ser Lys Ala  Lys Pro Ser Gly Ile  Ser Thr Ile 
    1100                 1105                 1110             


Val 
    


<210> 7711
<211> 300
<212> PRT
<213> Homo sapiens

<400> 7711
Met Ala Glu Glu Val Ser Thr Leu Met Lys Ala Thr Val Leu Met Arg 
1               5                   10                  15      


Gln Pro Gly Arg Val Gln Glu Ile Val Gly Ala Leu Arg Lys Gly Gly 
            20                  25                  30          


Gly Asp Arg Leu Gln Val Ile Ser Asp Phe Asp Met Thr Leu Ser Arg 
        35                  40                  45              


Phe Ala Tyr Asn Gly Lys Arg Cys Pro Ser Ser Tyr Asn Ile Leu Asp 
    50                  55                  60                  


Asn Ser Lys Ile Ile Ser Glu Glu Cys Arg Lys Glu Leu Thr Ala Leu 
65                  70                  75                  80  


Leu His His Tyr Tyr Pro Ile Glu Ile Asp Pro His Arg Thr Val Lys 
                85                  90                  95      


Glu Lys Leu Pro His Met Val Glu Trp Trp Thr Lys Ala His Asn Leu 
            100                 105                 110         


Leu Cys Gln Gln Lys Ile Gln Lys Phe Gln Ile Ala Gln Val Val Arg 
        115                 120                 125             


Glu Ser Asn Ala Met Leu Arg Glu Gly Tyr Lys Thr Phe Phe Asn Thr 
    130                 135                 140                 


Leu Tyr His Asn Asn Ile Pro Leu Phe Ile Phe Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Asp Ile Leu Glu Glu Ile Ile Arg Gln Met Lys Val Phe His Pro Asn 
                165                 170                 175     


Ile His Ile Val Ser Asn Tyr Met Asp Phe Asn Glu Asp Gly Phe Leu 
            180                 185                 190         


Gln Gly Phe Lys Gly Gln Leu Ile His Thr Tyr Asn Lys Asn Ser Ser 
        195                 200                 205             


Ala Cys Glu Asn Ser Gly Tyr Phe Gln Gln Leu Glu Gly Lys Thr Asn 
    210                 215                 220                 


Val Ile Leu Leu Gly Asp Ser Ile Gly Asp Leu Thr Met Ala Asp Gly 
225                 230                 235                 240 


Val Pro Gly Val Gln Asn Ile Leu Lys Ile Gly Phe Leu Asn Asp Lys 
                245                 250                 255     


Val Glu Glu Arg Arg Glu Arg Tyr Met Asp Ser Tyr Asp Ile Val Leu 
            260                 265                 270         


Glu Lys Asp Glu Thr Leu Asp Val Val Asn Gly Leu Leu Gln His Ile 
        275                 280                 285             


Leu Cys Gln Gly Val Gln Leu Glu Met Gln Gly Pro 
    290                 295                 300 


<210> 7712
<211> 277
<212> PRT
<213> Homo sapiens

<400> 7712
Met Phe Pro Gly Ala Thr Thr Pro Leu Pro Lys Ala Ala Ala Tyr Pro 
1               5                   10                  15      


Gly Val Tyr Gly Ser Asn Gly Arg Thr Pro Gln Pro Ala Tyr Leu Ser 
            20                  25                  30          


Glu Ala Met Lys Leu Thr Gln Ser Glu Gln Ala His Leu Ser Leu Glu 
        35                  40                  45              


Leu Gln Arg Asp Ser His Met Lys Gln Leu Leu Leu Ile Gln Glu Arg 
    50                  55                  60                  


Trp Lys Arg Ala Gln Arg Glu Glu Arg Leu Lys Ala Gln Gln Asn Thr 
65                  70                  75                  80  


Asp Lys Asp Ala Ala Ala His Leu Gln Thr Ser His Lys Pro Ser Ala 
                85                  90                  95      


Glu Asp Ala Glu Gly Gln Ser Pro Leu Ser Gln Lys Tyr Ser Pro Ser 
            100                 105                 110         


Thr Glu Lys Cys Leu Pro Glu Ile Gln Gly Ile Phe Asp Arg Asp Pro 
        115                 120                 125             


Asp Thr Leu Leu Tyr Leu Leu Gln Gln Lys Ser Glu Pro Ala Glu Pro 
    130                 135                 140                 


Cys Ile Gly Ser Lys Ala Pro Lys Asp Asp Lys Thr Ile Ile Glu Glu 
145                 150                 155                 160 


Gln Ala Thr Lys Ile Ala Asp Leu Lys Arg His Val Glu Phe Leu Val 
                165                 170                 175     


Ala Glu Asn Glu Arg Leu Arg Lys Glu Asn Lys Gln Leu Lys Ala Glu 
            180                 185                 190         


Lys Ala Arg Leu Leu Lys Gly Pro Ile Glu Lys Glu Leu Asp Val Asp 
        195                 200                 205             


Ala Asp Phe Val Glu Thr Ser Glu Leu Trp Ser Leu Pro Pro His Ala 
    210                 215                 220                 


Glu Thr Ala Thr Ala Ser Ser Thr Trp Gln Lys Phe Ala Ala Asn Thr 
225                 230                 235                 240 


Gly Lys Ala Lys Asp Ile Pro Ile Pro Asn Leu Pro Pro Leu Asp Phe 
                245                 250                 255     


Pro Ser Pro Glu Leu Pro Leu Met Glu Leu Ser Glu Asp Ile Leu Lys 
            260                 265                 270         


Gly Phe Met Asn Asn 
        275         


<210> 7713
<211> 45
<212> PRT
<213> Homo sapiens

<400> 7713
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr 
1               5                   10                  15      


Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val 
            20                  25                  30          


Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His 
        35                  40                  45  


<210> 7714
<211> 272
<212> PRT
<213> Homo sapiens

<400> 7714
Met Pro Gly Asp His Arg Arg Ile Arg Gly Pro Glu Glu Ser Gln Pro 
1               5                   10                  15      


Pro Gln Leu Tyr Ala Ala Asp Glu Glu Glu Ala Pro Gly Thr Arg Asp 
            20                  25                  30          


Pro Thr Arg Leu Arg Pro Val Tyr Ala Arg Ala Gly Leu Leu Ser Gln 
        35                  40                  45              


Ala Lys Gly Ser Ala Tyr Leu Glu Ala Gly Gly Thr Lys Val Leu Cys 
    50                  55                  60                  


Ala Val Ser Gly Pro Arg Gln Ala Glu Gly Gly Glu Arg Gly Gly Gly 
65                  70                  75                  80  


Pro Ala Gly Ala Gly Gly Glu Ala Pro Ala Ala Leu Arg Gly Arg Leu 
                85                  90                  95      


Leu Cys Asp Phe Arg Arg Ala Pro Phe Ala Gly Arg Arg Arg Arg Ala 
            100                 105                 110         


Pro Pro Gly Gly Cys Glu Glu Arg Glu Leu Ala Leu Ala Leu Gln Glu 
        115                 120                 125             


Ala Leu Glu Pro Ala Val Arg Leu Gly Arg Tyr Pro Arg Ala Gln Leu 
    130                 135                 140                 


Glu Val Ser Ala Leu Leu Leu Glu Asp Gly Gly Ser Ala Leu Ala Ala 
145                 150                 155                 160 


Ala Leu Thr Ala Ala Ala Leu Ala Leu Ala Asp Ala Gly Val Glu Met 
                165                 170                 175     


Tyr Asp Leu Val Val Gly Cys Gly Leu Ser Leu Ala Pro Gly Pro Ala 
            180                 185                 190         


Pro Thr Trp Leu Leu Asp Pro Thr Arg Leu Glu Glu Glu Arg Ala Ala 
        195                 200                 205             


Ala Gly Leu Thr Val Ala Leu Met Pro Val Leu Asn Gln Val Ala Gly 
    210                 215                 220                 


Leu Leu Gly Ser Gly Glu Gly Gly Leu Thr Glu Ser Trp Ala Glu Ala 
225                 230                 235                 240 


Val Arg Leu Gly Leu Glu Gly Cys Gln Arg Leu Tyr Pro Val Leu Gln 
                245                 250                 255     


Gln Ser Leu Val Arg Ala Ala Arg Arg Arg Gly Ala Ala Ala Gln Pro 
            260                 265                 270         


<210> 7715
<211> 142
<212> PRT
<213> Homo sapiens

<400> 7715
Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          


Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              


Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  


Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  


Phe Thr His Leu Ala Trp Tyr Glu Gln Gly Pro Lys Arg Glu Val Ala 
                85                  90                  95      


Ala Lys Leu Thr Pro Ser Gly Pro Ser Ser Val Ala Ser Trp Pro Leu 
            100                 105                 110         


Leu Asn Leu Trp Asn Leu Arg Phe Pro Ile Val Lys Ile Met Glu Thr 
        115                 120                 125             


Leu Pro Pro Lys Ser Leu Arg Met Met Thr Val Ile Ser Ile 
    130                 135                 140         


<210> 7716
<211> 378
<212> PRT
<213> Homo sapiens

<400> 7716
Met Glu Val Lys Pro Pro Pro Gly Arg Pro Gln Pro Asp Ser Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Gly Glu Glu Gly His Asp Pro Lys Glu Pro Glu 
            20                  25                  30          


Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp 
        35                  40                  45              


Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys 
    50                  55                  60                  


Val Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe 
65                  70                  75                  80  


Val Thr Tyr Ser Cys Val Glu Glu Val Asp Ala Ala Met Cys Ala Arg 
                85                  90                  95      


Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser 
            100                 105                 110         


Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr Val Lys Lys Ile 
        115                 120                 125             


Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp 
    130                 135                 140                 


Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu Val Met Glu Asp 
145                 150                 155                 160 


Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp 
                165                 170                 175     


His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr His Thr Ile Asn 
            180                 185                 190         


Gly His Asn Cys Glu Val Lys Lys Ala Leu Ser Lys Gln Glu Met Gln 
        195                 200                 205             


Ser Ala Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Phe Met 
    210                 215                 220                 


Gly Arg Gly Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser 
                245                 250                 255     


Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly 
            260                 265                 270         


Asp Gly Gly Asn Tyr Gly Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly 
        275                 280                 285             


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
    290                 295                 300                 


Gly Gly Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly 
305                 310                 315                 320 


Gly Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser 
                325                 330                 335     


Gly Gln Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly 
            340                 345                 350         


Gly Arg Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Tyr Gly Ser Arg Arg Phe 
    370                 375             


<210> 7717
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7717
Xaa Ile His Glu Gln Trp Glu Lys Ala Asn Val Ser Ser Pro His Arg 
1               5                   10                  15      


Glu Phe Pro Pro Ala Thr Ala Arg Glu Val Asp Pro Leu Arg Ile Pro 
            20                  25                  30          


Pro His His Pro His Thr Ser Arg Gln Pro Pro Trp Pro Arg Arg Gly 
        35                  40                  45              


Gly Met Ile Val Asp Pro Leu Arg Ser Gly Phe Pro Arg Ala Leu Ile 
    50                  55                  60                  


Asp Pro Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro Gly Ala Val Pro 
65                  70                  75                  80  


Pro Gly Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly Thr Ser Pro Pro 
                85                  90                  95      


Gly Pro Asn Pro Asp His Leu Pro Pro Pro Gly 
            100                 105         


<210> 7718
<211> 66
<212> PRT
<213> Homo sapiens

<400> 7718
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu 
65      


<210> 7719
<211> 704
<212> PRT
<213> Homo sapiens

<400> 7719
Met Leu Pro Thr Ala Ser Ser Lys Arg Arg Thr Phe Ala Ala Arg Tyr 
1               5                   10                  15      


Phe Thr Arg Ser Lys Ser Leu Val Met Gly Glu Gln Ser Arg Ser Pro 
            20                  25                  30          


Gly Arg Met Pro Cys Pro His Arg Leu Gly Pro Val Leu Lys Ala Gly 
        35                  40                  45              


Trp Leu Lys Lys Gln Arg Ser Ile Met Lys Asn Trp Gln Gln Arg Trp 
    50                  55                  60                  


Phe Val Leu Arg Gly Asp Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu 
65                  70                  75                  80  


Ile Lys Pro Gln Gly Phe Ile Ser Leu Gln Gly Thr Gln Val Thr Glu 
                85                  90                  95      


Leu Pro Pro Gly Pro Glu Asp Pro Gly Lys His Leu Phe Glu Ile Ser 
            100                 105                 110         


Pro Gly Gly Ala Gly Glu Arg Glu Lys Val Pro Ala Asn Pro Glu Ala 
        115                 120                 125             


Leu Leu Leu Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln 
    130                 135                 140                 


Ala Ile Arg Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly 
145                 150                 155                 160 


Gln Arg Leu Glu Glu Thr Val His His Glu Arg Lys Tyr Gly Pro Arg 
                165                 170                 175     


Leu Ala Pro Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg 
            180                 185                 190         


Gly Leu Thr Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu 
        195                 200                 205             


Val Arg Asp Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe 
    210                 215                 220                 


Asp Ser Thr Thr Asp Val His Thr Val Ala Ser Leu Leu Lys Leu Tyr 
225                 230                 235                 240 


Leu Arg Glu Leu Pro Glu Pro Val Val Pro Phe Ala Arg Tyr Glu Asp 
                245                 250                 255     


Phe Leu Ser Cys Ala Gln Leu Leu Thr Lys Asp Glu Gly Glu Gly Thr 
            260                 265                 270         


Leu Glu Leu Ala Lys Gln Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn 
        275                 280                 285             


Leu Leu Arg Tyr Ile Cys Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser 
    290                 295                 300                 


Asn Val Asn Lys Met Ser Val Gln Asn Leu Ala Thr Val Phe Gly Pro 
305                 310                 315                 320 


Asn Ile Leu Arg Pro Gln Val Glu Asp Pro Val Thr Ile Met Glu Gly 
                325                 330                 335     


Thr Ser Leu Val Gln His Leu Met Thr Val Leu Ile Arg Lys His Ser 
            340                 345                 350         


Gln Leu Phe Thr Ala Pro Val Pro Glu Gly Pro Thr Ser Pro Arg Gly 
        355                 360                 365             


Gly Leu Gln Cys Ala Val Gly Trp Gly Ser Glu Glu Val Thr Arg Asp 
    370                 375                 380                 


Ser Gln Gly Glu Pro Gly Gly Pro Gly Leu Pro Ala His Arg Thr Ser 
385                 390                 395                 400 


Ser Leu Asp Gly Ala Ala Val Ala Val Leu Ser Arg Thr Ala Pro Thr 
                405                 410                 415     


Gly Pro Gly Ser Arg Cys Ser Pro Gly Lys Lys Val Gln Thr Leu Pro 
            420                 425                 430         


Ser Trp Lys Ser Ser Phe Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro 
        435                 440                 445             


Lys Gly Gly Gly Ser Ser Leu Glu Val Pro Ile Ile Ser Ser Gly Gly 
    450                 455                 460                 


Asn Trp Leu Met Asn Gly Leu Ser Ser Leu Arg Gly His Arg Arg Ala 
465                 470                 475                 480 


Ser Ser Gly Asp Arg Leu Lys Asp Ser Gly Ser Val Gln Arg Leu Ser 
                485                 490                 495     


Thr Tyr Asp Asn Val Pro Ala Pro Gly Leu Val Pro Gly Ile Pro Ser 
            500                 505                 510         


Val Ala Ser Met Ala Trp Ser Gly Ala Ser Ser Ser Glu Ser Ser Val 
        515                 520                 525             


Gly Gly Ser Leu Ser Ser Cys Thr Ala Cys Arg Ala Ser Asp Ser Ser 
    530                 535                 540                 


Ala Arg Ser Ser Leu His Thr Asp Trp Ala Leu Glu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Ser Ser Ser Glu Asp Pro Lys Ser Leu Asp Leu Asp His Ser Met 
                565                 570                 575     


Asp Glu Ala Gly Ala Gly Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp 
            580                 585                 590         


Ser Pro Thr Arg Glu His Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu 
        595                 600                 605             


Val Thr Glu Leu Arg Ala Glu Leu Cys Arg Gln Arg Thr Glu Tyr Glu 
    610                 615                 620                 


Arg Ser Val Lys Arg Ile Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg 
625                 630                 635                 640 


Met Ser Arg Leu Glu Glu Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile 
                645                 650                 655     


Met Leu Glu Ile Lys Leu Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala 
            660                 665                 670         


Glu Arg Arg Asn Gln Leu Leu Gln Arg Glu Met Glu Glu Phe Phe Ser 
        675                 680                 685             


Thr Leu Gly Ser Leu Thr Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
    690                 695                 700                 


<210> 7720
<211> 209
<212> PRT
<213> Homo sapiens

<400> 7720
Met Ile Ser Asn Tyr Arg Asn Gly Ser Glu Leu Val Cys Phe Asn Ser 
1               5                   10                  15      


Gly Val Gly Cys Phe Leu Ile Gly Cys Asp Trp Ala Phe Thr Val Leu 
            20                  25                  30          


Val Asn Thr Phe Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile 
        35                  40                  45              


Gly Gly Glu Glu Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser 
    50                  55                  60                  


His His Asn Gln Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg 
65                  70                  75                  80  


Gln Glu Ala Glu Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala 
                85                  90                  95      


Lys Glu Ala Lys Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr 
            100                 105                 110         


Asp Glu Glu Ala Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp 
        115                 120                 125             


Ala Glu Asn His Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro 
    130                 135                 140                 


Gly Lys Gln Asp Thr Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys 
145                 150                 155                 160 


Gly Lys Leu Lys Pro Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr 
                165                 170                 175     


Arg Trp Thr Gln Thr Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys 
            180                 185                 190         


Val Asn Phe Arg Leu Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg 
        195                 200                 205             


Arg 
    


<210> 7721
<211> 102
<212> PRT
<213> Homo sapiens

<400> 7721
Met Asn Glu Ala Glu Ile Val Asp Val Ala Leu Gly Ile Leu Ile Glu 
1               5                   10                  15      


Ser Arg Lys Gln Glu Lys Ala Cys Glu Gln Pro Ala Leu Ala Gly Ala 
            20                  25                  30          


Asp Asn Pro Glu His Ser Pro Pro Cys Ser Val Ser Pro His Thr Ser 
        35                  40                  45              


Ser Gly Ser Ser Ser Glu Glu Glu Asp Ser Gly Lys Gln Ala Leu Ala 
    50                  55                  60                  


Pro Gly Leu Ser Pro Ser Gln Arg Pro Gly Gly Ser Ser Ser Ala Cys 
65                  70                  75                  80  


Ser Arg Ser Pro Glu Glu Glu Glu Glu Glu Asp Val Leu Lys Tyr Val 
                85                  90                  95      


Arg Glu Ile Phe Phe Ser 
            100         


<210> 7722
<211> 90
<212> PRT
<213> Homo sapiens

<400> 7722
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly 
                85                  90  


<210> 7723
<211> 68
<212> PRT
<213> Homo sapiens

<400> 7723
Met Asp Ala Asn Ser Lys Asp Lys Pro Pro Glu Thr Lys Glu Ser Ala 
1               5                   10                  15      


Met Asn Asn Ala Gly Asn Ala Ser Phe Ile Leu Gly Thr Gly Lys Ile 
            20                  25                  30          


Val Thr Pro Gln Lys His Ala Glu Leu Pro Pro Asn Pro Cys Thr Pro 
        35                  40                  45              


Asp Thr Phe Lys Ser Pro Leu Asn Phe Ser Thr Val Thr Val Glu Gln 
    50                  55                  60                  


Leu Gly Ile Asn 
65              


<210> 7724
<211> 292
<212> PRT
<213> Homo sapiens

<400> 7724
Met Asp Gly Ser Phe Val Gln His Ser Val Arg Val Leu Gln Glu Leu 
1               5                   10                  15      


Asn Lys Gln Arg Glu Lys Gly Gln Tyr Cys Asp Ala Thr Leu Asp Val 
            20                  25                  30          


Gly Gly Leu Val Phe Lys Ala His Trp Ser Val Leu Ala Cys Cys Ser 
        35                  40                  45              


His Phe Phe Gln Ser Leu Tyr Gly Asp Gly Ser Gly Gly Ser Val Val 
    50                  55                  60                  


Leu Pro Ala Gly Phe Ala Glu Ile Phe Gly Leu Leu Leu Asp Phe Phe 
65                  70                  75                  80  


Tyr Thr Gly His Leu Ala Leu Thr Ser Gly Asn Arg Asp Gln Val Leu 
                85                  90                  95      


Leu Ala Ala Arg Glu Leu Arg Val Pro Glu Ala Val Glu Leu Cys Gln 
            100                 105                 110         


Ser Phe Lys Pro Lys Thr Ser Val Gly Gln Ala Ala Gly Gly Gln Ser 
        115                 120                 125             


Gly Leu Gly Pro Pro Ala Ser Gln Asn Val Asn Ser His Val Lys Glu 
    130                 135                 140                 


Pro Ala Gly Leu Glu Glu Glu Glu Val Ser Arg Thr Leu Gly Leu Val 
145                 150                 155                 160 


Pro Arg Asp Gln Glu Pro Arg Gly Ser His Ser Pro Gln Arg Pro Gln 
                165                 170                 175     


Leu His Ser Pro Ala Gln Ser Glu Gly Pro Ser Ser Leu Cys Gly Lys 
            180                 185                 190         


Leu Lys Gln Ala Leu Lys Pro Cys Pro Leu Glu Asp Lys Lys Pro Glu 
        195                 200                 205             


Asp Cys Lys Val Pro Pro Arg Pro Leu Glu Ala Glu Gly Ala Gln Leu 
    210                 215                 220                 


Gln Gly Gly Ser Asn Glu Trp Glu Val Val Val Gln Val Glu Asp Asp 
225                 230                 235                 240 


Gly Asp Gly Asp Tyr Met Ser Glu Pro Glu Ala Val Leu Thr Arg Arg 
                245                 250                 255     


Lys Ser Asn Val Ile Arg Lys Pro Cys Ala Ala Glu Pro Ala Leu Ser 
            260                 265                 270         


Ala Gly Ser Leu Ala Ala Glu Pro Ala Glu Asn Arg Lys Gly Thr Ala 
        275                 280                 285             


Val Pro Val Glu 
    290         


<210> 7725
<211> 135
<212> PRT
<213> Homo sapiens

<400> 7725
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210> 7726
<211> 269
<212> PRT
<213> Homo sapiens

<400> 7726
Met Lys Thr Pro Val Glu Leu Ala Val Ser Gly Met Gln Thr Leu Gly 
1               5                   10                  15      


Leu Gln His Arg Cys Arg Gly Gly Tyr Arg Val Lys Ala Arg Thr Ser 
            20                  25                  30          


Tyr Val Asp Glu Thr Leu Phe Gly Ser Pro Ala Gly Thr Arg Pro Thr 
        35                  40                  45              


Pro Pro Asp Phe Asp Pro Pro Trp Val Glu Lys Ala Asn Arg Thr Arg 
    50                  55                  60                  


Gly Val Gly Lys Glu Ala Ser Lys Ala Leu Gly Ala Lys Gly Ser Cys 
65                  70                  75                  80  


Glu Thr Thr Pro Ser Arg Gly Ser Thr Pro Thr Leu Thr Pro Arg Lys 
                85                  90                  95      


Lys Asn Lys Tyr Arg Pro Ile Ser His Thr Pro Ser Tyr Cys Asp Glu 
            100                 105                 110         


Ser Leu Phe Gly Ser Arg Ser Glu Gly Ala Ser Phe Gly Ala Pro Arg 
        115                 120                 125             


Met Ala Lys Gly Asp Ala Ala Lys Leu Arg Ala Leu Leu Trp Thr Pro 
    130                 135                 140                 


Pro Pro Thr Pro Arg Gly Ser His Ser Pro Arg Pro Arg Glu Ala Pro 
145                 150                 155                 160 


Leu Arg Ala Ile His Pro Ala Gly Pro Ser Lys Thr Glu Pro Gly Pro 
                165                 170                 175     


Ala Ala Asp Ser Gln Lys Leu Ser Met Gly Gly Leu His Ser Ser Arg 
            180                 185                 190         


Pro Leu Lys Arg Gly Leu Ser His Ser Leu Thr His Leu Asn Val Pro 
        195                 200                 205             


Ser Thr Gly His Pro Ala Thr Ser Ala Pro His Thr Asn Gly Pro Gln 
    210                 215                 220                 


Asp Leu Arg Pro Ser Thr Ser Gly Val Thr Phe Arg Ser Pro Leu Val 
225                 230                 235                 240 


Thr Ser Arg Ala Arg Ser Val Ser Ile Ser Val Pro Ser Thr Pro Arg 
                245                 250                 255     


Arg Gly Gly Ala Thr Gln Lys Pro Lys Pro Pro Trp Lys 
            260                 265                 


<210> 7727
<211> 279
<212> PRT
<213> Homo sapiens

<400> 7727
Met Val Asp His Leu Ala Asn Thr Glu Ile Asn Ser Gln Arg Ile Ala 
1               5                   10                  15      


Ala Val Glu Ser Cys Phe Gly Ala Ser Gly Gln Pro Leu Ala Leu Pro 
            20                  25                  30          


Gly Arg Val Leu Leu Gly Glu Gly Val Leu Thr Lys Glu Cys Arg Lys 
        35                  40                  45              


Lys Ala Lys Pro Arg Ile Phe Phe Leu Phe Asn Asp Ile Leu Val Tyr 
    50                  55                  60                  


Gly Ser Ile Val Leu Asn Lys Arg Lys Tyr Arg Ser Gln His Ile Ile 
65                  70                  75                  80  


Pro Leu Glu Glu Val Thr Leu Glu Leu Leu Pro Glu Thr Leu Gln Ala 
                85                  90                  95      


Lys Asn Arg Trp Met Ile Lys Thr Ala Lys Lys Ser Phe Val Val Ser 
            100                 105                 110         


Ala Ala Ser Ala Thr Glu Arg Gln Glu Trp Ile Ser His Ile Glu Glu 
        115                 120                 125             


Cys Val Arg Arg Gln Leu Arg Ala Thr Gly Arg Pro Pro Ser Thr Glu 
    130                 135                 140                 


His Ala Ala Pro Trp Ile Pro Asp Lys Ala Thr Asp Ile Cys Met Arg 
145                 150                 155                 160 


Cys Thr Gln Thr Arg Phe Ser Ala Leu Thr Arg Arg His His Cys Arg 
                165                 170                 175     


Lys Cys Gly Phe Val Val Cys Ala Glu Cys Ser Arg Gln Arg Phe Leu 
            180                 185                 190         


Leu Pro Arg Leu Ser Pro Lys Pro Val Arg Val Cys Ser Leu Cys Tyr 
        195                 200                 205             


Arg Glu Leu Ala Ala Gln Gln Arg Gln Glu Glu Ala Glu Glu Gln Gly 
    210                 215                 220                 


Ala Gly Ser Pro Gly Gln Pro Ala His Leu Ala Arg Pro Ile Cys Gly 
225                 230                 235                 240 


Ala Ser Ser Gly Asp Asp Asp Asp Ser Asp Glu Asp Lys Glu Gly Ser 
                245                 250                 255     


Arg Asp Gly Asp Trp Pro Ser Ser Val Glu Phe Tyr Ala Ser Gly Val 
            260                 265                 270         


Ala Trp Ser Ala Phe His Ser 
        275                 


<210> 7728
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7728
Xaa Arg Ser Ser Thr Ser Pro Cys Gly Thr Ser Lys Ser Pro Asn Arg 
1               5                   10                  15      


Glu Trp Glu Gly Lys Ser Val Ala Tyr Met Pro Tyr Ala Glu Val Lys 
            20                  25                  30          


Arg Ala Leu Glu Gln Glu Ala Gln Met His Asn Thr Ala Ala Arg Ser 
        35                  40                  45              


Ala Ser Pro Cys Arg Leu Ser Pro Arg Glu Val Ser Lys Ala Ala Pro 
    50                  55                  60                  


Gln Pro Asp Met Ser Ala Ala Arg Tyr Ser Val Pro Pro Val Leu Gln 
65                  70                  75                  80  


Pro Ala Pro His Gln Val Ile Thr Asn Leu Pro Glu 
                85                  90          


<210> 7729
<211> 256
<212> PRT
<213> Homo sapiens

<400> 7729
Met Ser Asn Asn Leu Ser Glu Leu Asp Thr Lys Ile Gln Glu Lys Ala 
1               5                   10                  15      


Met Lys Val Asp Met Asp Ile Cys Arg Arg Ile Asp Ile Thr Ala Lys 
            20                  25                  30          


Leu Cys Asp Val Ala Gln Gln Arg Asn Cys Glu Asp Met Ile Gln Met 
        35                  40                  45              


Phe Gln Lys Lys Leu Val Pro Ser Met Gly Gly Arg Lys Arg Glu Arg 
    50                  55                  60                  


Lys Ala Ala Val Glu Glu Asp Thr Ser Leu Ser Glu Ser Glu Gly Pro 
65                  70                  75                  80  


Arg Gln Pro Asp Gly Asp Glu Glu Glu Ser Thr Ala Leu Ser Ile Asn 
                85                  90                  95      


Glu Glu Met Gln Arg Met Leu Asn Gln Leu Arg Glu Tyr Asp Phe Glu 
            100                 105                 110         


Asp Asp Cys Asp Ser Leu Thr Trp Glu Glu Thr Glu Glu Thr Leu Leu 
        115                 120                 125             


Leu Trp Glu Asp Phe Ser Gly Tyr Ala Met Ala Ala Ala Glu Ala Gln 
    130                 135                 140                 


Gly Glu Gln Gln Glu Asp Ser Leu Glu Lys Val Ile Lys Asp Thr Glu 
145                 150                 155                 160 


Ser Leu Phe Lys Thr Arg Glu Lys Glu Tyr Gln Glu Thr Ile Asp Gln 
                165                 170                 175     


Ile Glu Leu Glu Leu Ala Thr Ala Lys Asn Asp Met Asn Arg His Leu 
            180                 185                 190         


His Glu Tyr Met Glu Met Cys Ser Met Lys Arg Gly Leu Asp Val Gln 
        195                 200                 205             


Met Glu Thr Cys Arg Arg Leu Ile Thr Gln Ser Gly Asp Arg Lys Ser 
    210                 215                 220                 


Pro Ala Phe Thr Ala Val Pro Leu Ser Asp Pro Pro Pro Pro Pro Ser 
225                 230                 235                 240 


Glu Ala Glu Asp Ser Asp Arg Asp Val Ser Ser Asp Ser Ser Met Arg 
                245                 250                 255     


<210> 7730
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7730
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7731
<211> 249
<212> PRT
<213> Homo sapiens

<400> 7731
Met Ala Phe Met Thr Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys 
1               5                   10                  15      


Ala Gln Thr Asp Glu Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu 
            20                  25                  30          


Glu Asp Leu Val Gln Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu 
        35                  40                  45              


Gln Arg Gln Glu Glu Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln 
    50                  55                  60                  


Val Arg Glu Met Glu Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val 
65                  70                  75                  80  


Gly Glu Pro Met Asp Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu 
                85                  90                  95      


His Gly Glu Arg Asp Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly 
            100                 105                 110         


Asp Ser Leu Ala Pro Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser 
        115                 120                 125             


Leu Gln Asp Leu Ser Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr 
    130                 135                 140                 


Pro Val Pro Gly Gly Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu 
145                 150                 155                 160 


Lys Leu Tyr Arg Asn Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro 
                165                 170                 175     


Phe Tyr Asp Pro Ser Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly 
            180                 185                 190         


Phe Phe Pro Ser Glu Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe 
        195                 200                 205             


Lys Val Ile Ser Cys Ser Ser Asn His Thr Phe Gly Asp Phe Glu Gly 
    210                 215                 220                 


Ser Gly Asp Thr Gln Pro Pro Gln Thr Pro Pro Ile Leu Arg Gly Ser 
225                 230                 235                 240 


Arg Cys Thr Pro Trp Gly Thr Pro Val 
                245                 


<210> 7732
<211> 920
<212> PRT
<213> Homo sapiens

<400> 7732
Met Ser Glu Asp Ser Glu Lys Glu Asp Tyr Ser Asp Arg Thr Ile Ser 
1               5                   10                  15      


Asp Glu Asp Glu Ser Asp Glu Asp Met Phe Met Lys Phe Val Ser Glu 
            20                  25                  30          


Asp Leu His Arg Cys Ala Leu Leu Thr Ala Asp Ser Phe Gly Asp Pro 
        35                  40                  45              


Phe Phe Pro Arg Thr Thr Gln Ile Leu Leu Glu Tyr Gln Leu Gly Arg 
    50                  55                  60                  


Trp Val Pro Arg Leu Arg Glu Pro Arg Asp Leu Tyr Gly Val Ser Ser 
65                  70                  75                  80  


Ser Gly Pro Leu Ser Pro Thr Arg Trp Pro Tyr His Cys Glu Val Ile 
                85                  90                  95      


Asp Glu Lys Val Gln His Ile Asp Trp Thr Pro Ser Cys Pro Glu Pro 
            100                 105                 110         


Val Tyr Ile Pro Thr Gly Leu Glu Thr Glu Pro Leu Tyr Pro Asp Ser 
        115                 120                 125             


Lys Glu Ala Thr Val Val Tyr Leu Ala Glu Asp Ala Tyr Lys Glu Pro 
    130                 135                 140                 


Cys Phe Val Tyr Ser Arg Val Gly Gly Asn Arg Thr Pro Leu Lys Gln 
145                 150                 155                 160 


Pro Val Asp Tyr Arg Asp Asn Thr Leu Met Phe Glu Ala Arg Phe Glu 
                165                 170                 175     


Ser Gly Asn Leu Gln Lys Val Val Lys Val Ala Glu Tyr Glu Tyr Gln 
            180                 185                 190         


Leu Thr Val Arg Pro Asp Leu Phe Thr Asn Lys His Thr Gln Trp Tyr 
        195                 200                 205             


Tyr Phe Gln Val Thr Asn Met Arg Ala Gly Ile Val Tyr Arg Phe Thr 
    210                 215                 220                 


Ile Val Asn Phe Thr Lys Pro Ala Ser Leu Tyr Ser Arg Gly Met Arg 
225                 230                 235                 240 


Pro Leu Phe Tyr Ser Glu Lys Glu Ala Lys Ala His His Ile Gly Trp 
                245                 250                 255     


Gln Arg Ile Gly Asp Gln Ile Lys Tyr Tyr Arg Asn Asn Pro Gly Gln 
            260                 265                 270         


Asp Gly Arg His Tyr Phe Ser Leu Thr Trp Thr Phe Gln Phe Pro His 
        275                 280                 285             


Asn Lys Asp Thr Cys Tyr Phe Ala His Cys Tyr Pro Tyr Thr Tyr Thr 
    290                 295                 300                 


Asn Leu Gln Glu Tyr Leu Ser Gly Ile Asn Asn Asp Pro Val Arg Ser 
305                 310                 315                 320 


Lys Phe Cys Lys Ile Arg Val Leu Cys His Thr Leu Ala Arg Asn Met 
                325                 330                 335     


Val Tyr Ile Leu Thr Ile Thr Thr Pro Leu Lys Asn Ser Asp Ser Arg 
            340                 345                 350         


Lys Arg Lys Ala Val Ile Leu Thr Ala Arg Val His Pro Gly Glu Thr 
        355                 360                 365             


Asn Ser Ser Trp Ile Met Lys Gly Phe Leu Asp Tyr Ile Leu Gly Asn 
    370                 375                 380                 


Ser Ser Asp Ala Gln Leu Leu Arg Asp Thr Phe Val Phe Lys Val Val 
385                 390                 395                 400 


Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg Cys Ser 
                405                 410                 415     


Leu Ala Gly Arg Asp Leu Asn Arg Asn Tyr Thr Ser Leu Leu Lys Glu 
            420                 425                 430         


Ser Phe Pro Ser Val Trp Tyr Thr Arg Asn Met Val His Arg Leu Met 
        435                 440                 445             


Glu Lys Arg Glu Val Ile Leu Tyr Cys Asp Leu His Gly His Ser Arg 
    450                 455                 460                 


Lys Glu Asn Ile Phe Met Tyr Gly Cys Asp Gly Ser Asp Arg Ser Lys 
465                 470                 475                 480 


Thr Leu Tyr Leu Gln Gln Arg Ile Phe Pro Leu Met Leu Ser Lys Asn 
                485                 490                 495     


Cys Pro Asp Lys Phe Ser Phe Ser Ala Cys Lys Phe Asn Val Gln Lys 
            500                 505                 510         


Ser Lys Glu Gly Thr Gly Arg Val Val Met Trp Lys Met Gly Ile Arg 
        515                 520                 525             


Asn Ser Phe Thr Met Glu Ala Thr Phe Cys Gly Ser Thr Leu Gly Asn 
    530                 535                 540                 


Lys Arg Gly Thr His Phe Ser Thr Lys Asp Leu Glu Ser Met Gly Tyr 
545                 550                 555                 560 


His Phe Cys Asp Ser Leu Leu Asp Tyr Cys Asp Pro Asp Arg Thr Lys 
                565                 570                 575     


Tyr Tyr Arg Cys Leu Lys Glu Leu Glu Glu Met Glu Arg His Ile Thr 
            580                 585                 590         


Leu Glu Lys Val Phe Glu Asp Ser Asp Thr Pro Val Ile Asp Ile Thr 
        595                 600                 605             


Leu Asp Val Glu Ser Ser Ser Arg Gly Ser Asp Ser Ser Glu Ser Ile 
    610                 615                 620                 


Asp Ser Leu Thr Tyr Leu Leu Lys Leu Thr Ser Gln Lys Lys His Leu 
625                 630                 635                 640 


Lys Thr Lys Lys Glu Arg Asn Ser Thr Ile Ala Ser His Gln Asn Ala 
                645                 650                 655     


Arg Gly Gln Glu Val Tyr Asp Arg Gly His Leu Leu Gln Arg His Thr 
            660                 665                 670         


Gln Ser Asn Ser Asp Val Lys Asp Thr Arg Pro Asn Glu Pro Asp Asp 
        675                 680                 685             


Tyr Met Val Asp Tyr Phe Arg Arg Gln Leu Pro Asn Gln Gly Leu Asp 
    690                 695                 700                 


Leu His His Asn Leu Lys Ser Lys Ile Lys Glu Cys Ile Ser Phe Gln 
705                 710                 715                 720 


Ser Lys Lys Thr Gly Ile Asn Trp Thr Asp Asp Glu Lys Arg Ser Tyr 
                725                 730                 735     


Lys Asp Lys Gly Ile Val Gln Thr Gln Glu Ile Leu Gln Tyr Leu Leu 
            740                 745                 750         


Pro Ile Val His Ser Thr Lys Asn Met Gln Thr Thr Gln Ile Lys Gln 
        755                 760                 765             


Leu Phe Asn Pro Arg Thr Asn Phe Gln Ile Gln His Gln Leu Asn Pro 
    770                 775                 780                 


Ala Thr Cys Arg Asn Ile Lys Lys Tyr Ser Thr Ser Trp Thr Ala Pro 
785                 790                 795                 800 


Arg Asn His Pro Phe Val Ile Gln Gly Asp Val Met Ala Asn Ser Ser 
                805                 810                 815     


Glu Trp Val Gln Ser Lys Pro His Arg Ser Leu Glu Ser Leu Ser Pro 
            820                 825                 830         


Leu Lys Gly Pro Lys Lys Asn Lys His Ser Gln Ile Trp Ala Ile Lys 
        835                 840                 845             


Asn Glu Asp Ile Lys Pro Leu Ser Ser Lys Trp Glu Thr Ala Ser Ser 
    850                 855                 860                 


Ser Phe Gly Met Asp Ala Asn Val Leu Lys Tyr Lys Ser Leu Gln Ala 
865                 870                 875                 880 


Glu Glu Thr Asn Gln Gln Ser Ser Lys His Thr Ala Leu His Leu Thr 
                885                 890                 895     


Lys Asn Lys Asp Glu Gln Ala Asn Lys Asn Asp Gly Gln Pro Thr Leu 
            900                 905                 910         


Tyr Leu Lys Phe Gln Arg Glu Ser 
        915                 920 


<210> 7733
<211> 285
<212> PRT
<213> Homo sapiens

<400> 7733
Met Thr Asn Ala Gln Ile Ile Leu Leu Ile Asp Asn Ala Arg Met Ala 
1               5                   10                  15      


Val Asp Asp Phe Asn Leu Lys Tyr Glu Asn Glu His Ser Phe Lys Lys 
            20                  25                  30          


Asp Leu Glu Ile Glu Val Glu Gly Leu Arg Arg Thr Leu Asp Asn Leu 
        35                  40                  45              


Thr Ile Val Thr Thr Asp Leu Glu Gln Glu Val Glu Gly Met Arg Lys 
    50                  55                  60                  


Glu Leu Ile Leu Met Lys Lys His His Glu Gln Glu Met Glu Lys His 
65                  70                  75                  80  


His Val Pro Ser Asp Phe Asn Val Asn Val Lys Val Asp Thr Gly Pro 
                85                  90                  95      


Arg Glu Asp Leu Ile Lys Val Leu Glu Asp Met Arg Gln Glu Tyr Glu 
            100                 105                 110         


Leu Ile Ile Lys Lys Lys His Arg Asp Leu Asp Thr Trp Tyr Lys Glu 
        115                 120                 125             


Gln Ser Ala Ala Met Ser Gln Glu Ala Ala Ser Pro Ala Thr Val Gln 
    130                 135                 140                 


Ser Arg Gln Gly Asp Ile His Glu Leu Lys Arg Thr Phe Gln Ala Leu 
145                 150                 155                 160 


Glu Ile Asp Leu Gln Thr Gln Tyr Ser Thr Lys Ser Ala Leu Glu Asn 
                165                 170                 175     


Met Leu Ser Glu Thr Gln Ser Arg Tyr Ser Cys Lys Leu Gln Asp Met 
            180                 185                 190         


Gln Glu Ile Ile Ser His Tyr Glu Glu Glu Leu Thr Gln Leu Arg His 
        195                 200                 205             


Glu Leu Glu Arg Gln Asn Asn Glu Tyr Gln Val Leu Leu Gly Ile Lys 
    210                 215                 220                 


Thr His Leu Glu Lys Glu Ile Thr Thr Tyr Arg Arg Leu Leu Glu Gly 
225                 230                 235                 240 


Glu Ser Glu Gly Thr Arg Glu Glu Ser Lys Ser Ser Met Lys Val Ser 
                245                 250                 255     


Ala Thr Pro Lys Ile Lys Ala Ile Thr Gln Glu Thr Ile Asn Gly Arg 
            260                 265                 270         


Leu Val Leu Cys Gln Val Asn Glu Ile Gln Lys His Ala 
        275                 280                 285 


<210> 7734
<211> 670
<212> PRT
<213> Homo sapiens

<400> 7734
Met Ser Pro Cys Ser Gly Gly Arg Gly Glu Leu Arg Ala Ala Cys Leu 
1               5                   10                  15      


Gln Pro Glu Val Pro Gly Ala Pro Gly Leu Ser Trp Trp Pro Ser Thr 
            20                  25                  30          


Ala Gly Leu Arg Gln Ser Gln Thr Asp Leu Gln Leu Ser Leu Ser Ile 
        35                  40                  45              


Trp Cys Gly Lys Lys Met Gly Ser Tyr Leu Ser Val Pro Ala Tyr Phe 
    50                  55                  60                  


Thr Ser Arg Asp Leu Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr 
65                  70                  75                  80  


Asn Trp Tyr Tyr Glu Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr 
                85                  90                  95      


Trp Gly Lys Phe Gly Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr 
            100                 105                 110         


Gly Pro Phe Met Val Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe 
        115                 120                 125             


Ala Cys Met Ser Cys Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala 
    130                 135                 140                 


Leu Val Gln His Ala Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val 
145                 150                 155                 160 


Val Leu Ala Pro Met Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu 
                165                 170                 175     


Gln Leu Pro Tyr Ser Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu 
            180                 185                 190         


Gly Arg Arg Gly Phe Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr 
        195                 200                 205             


Ala Thr Thr Val Gln Val Lys Glu Val Asn Arg Met His Ile Ser Pro 
    210                 215                 220                 


Asn Asn Arg Asn Ala Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn 
225                 230                 235                 240 


Gly Thr Pro Val Arg Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile 
                245                 250                 255     


Ser Gln Thr Ser Gln Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val 
            260                 265                 270         


Ser Gln Arg Leu Asp Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His 
        275                 280                 285             


Met Gln Asn Ala Gly His Pro His Ala Leu Ser Thr Leu Asp Thr Lys 
    290                 295                 300                 


Glu Asn Leu Glu Gly Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn 
305                 310                 315                 320 


Ser Ile Ser Lys Ser Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu 
                325                 330                 335     


Phe Ser Arg Asp Ile Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser 
            340                 345                 350         


Tyr Ser Gln Gln Ile Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val 
        355                 360                 365             


Leu Gly Lys Gly Phe Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala 
    370                 375                 380                 


Thr Gly Lys Val Met Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu 
385                 390                 395                 400 


Thr Gln Lys Thr Phe Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp 
                405                 410                 415     


His Pro Asn Val Leu Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys 
            420                 425                 430         


Leu Asn Leu Leu Thr Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe 
        435                 440                 445             


Leu Arg Ser Met Asp Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala 
    450                 455                 460                 


Lys Gly Ile Ala Ser Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile 
465                 470                 475                 480 


His Arg Asp Leu Asn Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr 
                485                 490                 495     


Val Val Val Ala Asp Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg 
            500                 505                 510         


Lys Arg Ala Pro Met Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg 
        515                 520                 525             


Lys Asn Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp 
    530                 535                 540                 


Met Ala Pro Glu Met Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp 
545                 550                 555                 560 


Ile Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr 
                565                 570                 575     


Ala Asp Pro Asp Cys Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val 
            580                 585                 590         


Lys Leu Phe Trp Glu Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe 
        595                 600                 605             


Phe Pro Leu Ala Ala Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Pro 
    610                 615                 620                 


Ala Phe Ser Lys Leu Glu Asp Ser Phe Glu Ala Leu Ser Leu Tyr Leu 
625                 630                 635                 640 


Gly Glu Leu Gly Ile Pro Leu Pro Ala Glu Leu Glu Glu Leu Asp His 
                645                 650                 655     


Thr Val Ser Met Gln Tyr Gly Leu Thr Arg Asp Ser Pro Pro 
            660                 665                 670 


<210> 7735
<211> 152
<212> PRT
<213> Homo sapiens

<400> 7735
Met Ala His Leu Arg Gly Phe Ala Asn Gln His Ser Arg Val Asp Pro 
1               5                   10                  15      


Glu Glu Leu Phe Thr Lys Leu Asp Arg Ile Gly Lys Gly Ser Phe Gly 
            20                  25                  30          


Glu Val Tyr Lys Gly Ile Asp Asn His Thr Lys Glu Val Val Ala Ile 
        35                  40                  45              


Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln 
    50                  55                  60                  


Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Ile Thr Arg 
65                  70                  75                  80  


Tyr Phe Gly Ser Tyr Leu Lys Ser Thr Lys Leu Trp Ile Ile Met Glu 
                85                  90                  95      


Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly Pro Leu 
            100                 105                 110         


Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu 
        115                 120                 125             


Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys Ala Ala 
    130                 135                 140                 


Asn Val Leu Leu Ser Glu Gln Gly 
145                 150         


<210> 7736
<211> 454
<212> PRT
<213> Homo sapiens

<400> 7736
Met Ala Pro Cys Arg Ala Arg Thr Gly Pro Ser Thr Trp Arg Ser Ala 
1               5                   10                  15      


Thr Ser Ser Thr Arg Arg Arg Lys Gly Ala Arg Arg His Leu Ser Ala 
            20                  25                  30          


Leu Gln Val Leu Glu Thr Cys Val Lys Asn Cys Gly His Arg Phe His 
        35                  40                  45              


Val Leu Val Ala Ser Gln Asp Phe Val Glu Ser Val Leu Val Arg Thr 
    50                  55                  60                  


Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile Val His Asp Lys Val Leu 
65                  70                  75                  80  


Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe Arg Ser Ser Pro Asp Leu 
                85                  90                  95      


Thr Gly Val Val Thr Ile Tyr Glu Asp Leu Arg Arg Lys Gly Leu Glu 
            100                 105                 110         


Phe Pro Met Thr Asp Leu Asp Met Leu Ser Pro Ile His Thr Pro Gln 
        115                 120                 125             


Arg Thr Val Phe Asn Ser Glu Thr Gln Ser Gly Gln Asp Ser Val Gly 
    130                 135                 140                 


Thr Asp Ser Ser Gln Gln Glu Asp Ser Gly Gln His Ala Ala Pro Leu 
145                 150                 155                 160 


Pro Ala Pro Pro Ile Leu Ser Gly Asp Thr Pro Ile Ala Pro Thr Pro 
                165                 170                 175     


Glu Gln Ile Gly Lys Leu Arg Ser Glu Leu Glu Met Val Ser Gly Asn 
            180                 185                 190         


Val Arg Val Met Ser Glu Met Leu Thr Glu Leu Val Pro Thr Gln Ala 
        195                 200                 205             


Glu Pro Ala Asp Leu Glu Leu Leu Gln Glu Leu Asn Arg Thr Cys Arg 
    210                 215                 220                 


Ala Met Gln Gln Arg Val Leu Glu Leu Ile Pro Gln Ile Ala Asn Glu 
225                 230                 235                 240 


Gln Leu Thr Glu Glu Leu Leu Ile Val Asn Asp Asn Leu Asn Asn Val 
                245                 250                 255     


Phe Leu Arg His Glu Arg Phe Glu Arg Phe Arg Thr Gly Gln Thr Thr 
            260                 265                 270         


Lys Ala Pro Ser Glu Ala Glu Pro Ala Ala Asp Leu Ile Asp Met Gly 
        275                 280                 285             


Pro Asp Pro Ala Ala Thr Gly Asn Leu Ser Ser Gln Leu Ala Gly Met 
    290                 295                 300                 


Asn Leu Gly Ser Ser Ser Val Arg Ala Gly Leu Gln Ser Leu Glu Ala 
305                 310                 315                 320 


Ser Gly Arg Leu Glu Asp Glu Phe Asp Met Phe Ala Leu Thr Arg Gly 
                325                 330                 335     


Ser Ser Leu Ala Asp Gln Arg Lys Glu Val Lys Tyr Glu Ala Pro Gln 
            340                 345                 350         


Ala Thr Asp Gly Leu Ala Gly Ala Leu Asp Ala Arg Gln Gln Ser Thr 
        355                 360                 365             


Gly Ala Ile Pro Val Thr Gln Ala Cys Leu Met Glu Asp Ile Glu Gln 
    370                 375                 380                 


Trp Leu Ser Thr Asp Val Gly Asn Asp Ala Glu Glu Pro Lys Gly Val 
385                 390                 395                 400 


Thr Ser Glu Glu Phe Asp Lys Phe Leu Glu Glu Arg Ala Lys Ala Ala 
                405                 410                 415     


Asp Arg Leu Pro Asn Leu Ser Ser Pro Ser Ala Glu Gly Pro Pro Gly 
            420                 425                 430         


Pro Pro Ser Gly Pro Ala Pro Arg Lys Lys Thr Gln Glu Lys Asp Asp 
        435                 440                 445             


Asp Met Leu Phe Ala Leu 
    450                 


<210> 7737
<211> 125
<212> PRT
<213> Homo sapiens

<400> 7737
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met 
            100                 105                 110         


Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe 
        115                 120                 125 


<210> 7738
<211> 9
<212> PRT
<213> Homo sapiens

<400> 7738
Met Ser His Leu Gln Ser Leu Leu Leu 
1               5                   


<210> 7739
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7739
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 7740
<211> 1243
<212> PRT
<213> Homo sapiens

<400> 7740
Met Leu Ile Lys Glu Tyr His Ile Leu Leu Pro Met Ser Leu Asp Glu 
1               5                   10                  15      


Tyr Gln Val Ala Gln Leu Tyr Met Ile Gln Lys Lys Ser Arg Glu Glu 
            20                  25                  30          


Ser Ser Gly Glu Gly Ser Gly Val Glu Ile Leu Ala Asn Arg Pro Tyr 
        35                  40                  45              


Thr Asp Gly Pro Gly Gly Ser Gly Gln Tyr Thr His Lys Val Tyr His 
    50                  55                  60                  


Val Gly Ser His Ile Pro Gly Trp Phe Arg Ala Leu Leu Pro Lys Ala 
65                  70                  75                  80  


Ala Leu Gln Val Glu Glu Glu Ser Trp Asn Ala Tyr Pro Tyr Thr Arg 
                85                  90                  95      


Thr Arg Tyr Thr Cys Pro Phe Val Glu Lys Phe Ser Ile Glu Ile Glu 
            100                 105                 110         


Thr Tyr Tyr Leu Pro Asp Gly Gly Gln Gln Pro Asn Val Phe Asn Leu 
        115                 120                 125             


Ser Gly Ala Glu Arg Arg Gln Arg Ile Leu Asp Thr Ile Asp Ile Val 
    130                 135                 140                 


Arg Asp Ala Val Ala Pro Gly Glu Tyr Lys Ala Glu Glu Asp Pro Arg 
145                 150                 155                 160 


Leu Tyr His Ser Val Lys Thr Gly Arg Gly Pro Leu Ser Asp Asp Trp 
                165                 170                 175     


Ala Arg Thr Ala Ala Gln Thr Gly Pro Leu Met Cys Ala Tyr Lys Leu 
            180                 185                 190         


Cys Lys Val Glu Phe Arg Tyr Trp Gly Met Gln Ala Lys Ile Glu Gln 
        195                 200                 205             


Phe Ile His Asp Val Gly Leu Arg Arg Val Met Leu Arg Ala His Arg 
    210                 215                 220                 


Gln Ala Trp Cys Trp Gln Asp Glu Trp Thr Glu Leu Ser Met Ala Asp 
225                 230                 235                 240 


Ile Arg Ala Leu Glu Glu Glu Thr Ala Arg Met Leu Ala Gln Arg Met 
                245                 250                 255     


Ala Lys Cys Asn Thr Gly Ser Glu Gly Ser Glu Ala Gln Pro Pro Gly 
            260                 265                 270         


Lys Pro Ser Thr Glu Ala Arg Ser Ala Ala Ser Asn Thr Gly Thr Pro 
        275                 280                 285             


Asp Gly Pro Glu Ala Pro Pro Gly Pro Asp Ala Ser Pro Asp Ala Ser 
    290                 295                 300                 


Phe Gly Lys Gln Trp Ser Ser Ser Ser Arg Ser Ser Tyr Ser Ser Gln 
305                 310                 315                 320 


His Gly Gly Ala Val Ser Pro Gln Ser Leu Ser Glu Trp Arg Met Gln 
                325                 330                 335     


Asn Ile Ala Arg Asp Ser Glu Asn Ser Ser Glu Glu Glu Phe Phe Asp 
            340                 345                 350         


Ala His Glu Gly Phe Ser Asp Ser Glu Glu Val Phe Pro Lys Glu Met 
        355                 360                 365             


Thr Lys Trp Asn Ser Asn Asp Phe Ile Asp Ala Phe Ala Ser Pro Val 
    370                 375                 380                 


Glu Ala Glu Gly Thr Pro Glu Pro Gly Ala Glu Ala Ala Lys Gly Ile 
385                 390                 395                 400 


Glu Asp Gly Ala Gln Ala Pro Arg Asp Ser Glu Gly Leu Asp Gly Ala 
                405                 410                 415     


Gly Glu Leu Gly Ala Glu Ala Cys Ala Val His Ala Leu Phe Leu Ile 
            420                 425                 430         


Leu His Ser Gly Asn Ile Leu Asp Ser Gly Pro Gly Asp Ala Asn Ser 
        435                 440                 445             


Lys Gln Ala Asp Val Gln Thr Leu Ser Ser Ala Phe Glu Ala Val Thr 
    450                 455                 460                 


Arg Ile His Phe Pro Glu Ala Leu Gly His Val Ala Leu Arg Leu Val 
465                 470                 475                 480 


Pro Cys Pro Pro Ile Cys Ala Ala Ala Tyr Ala Leu Val Ser Asn Leu 
                485                 490                 495     


Ser Pro Tyr Ser His Asp Gly Asp Ser Leu Ser Arg Ser Gln Asp His 
            500                 505                 510         


Ile Pro Leu Ala Ala Leu Pro Leu Leu Ala Thr Ser Ser Ser Arg Tyr 
        515                 520                 525             


Gln Gly Ala Val Ala Thr Val Ile Ala Arg Thr Asn Gln Ala Tyr Ser 
    530                 535                 540                 


Ala Phe Leu Arg Ser Pro Glu Gly Ala Gly Phe Cys Gly Gln Val Ala 
545                 550                 555                 560 


Leu Ile Gly Asp Gly Val Gly Gly Ile Leu Gly Phe Asp Ala Leu Cys 
                565                 570                 575     


His Ser Ala Asn Ala Gly Thr Gly Ser Arg Gly Ser Ser Arg Arg Gly 
            580                 585                 590         


Ser Met Asn Asn Glu Leu Leu Ser Pro Glu Phe Gly Pro Val Arg Asp 
        595                 600                 605             


Pro Leu Ala Asp Gly Val Glu Gly Leu Gly Arg Gly Ser Pro Glu Pro 
    610                 615                 620                 


Ser Ala Leu Pro Pro Gln Arg Ile Pro Ser Asp Met Ala Ser Pro Glu 
625                 630                 635                 640 


Pro Glu Gly Ser Gln Asn Ser Leu Gln Ala Ala Pro Ala Thr Thr Ser 
                645                 650                 655     


Ser Trp Glu Pro Arg Arg Ala Ser Thr Ala Phe Cys Pro Pro Ala Ala 
            660                 665                 670         


Ser Ser Glu Ala Pro Asp Gly Pro Ser Ser Thr Ala Arg Leu Asp Phe 
        675                 680                 685             


Lys Val Ser Gly Phe Phe Leu Phe Gly Ser Pro Leu Gly Leu Val Leu 
    690                 695                 700                 


Ala Leu Arg Lys Thr Val Met Pro Ala Leu Glu Ala Gln Met Arg Pro 
705                 710                 715                 720 


Ala Cys Glu Gln Ile Tyr Asn Leu Phe His Ala Ala Asp Pro Cys Ala 
                725                 730                 735     


Ser Arg Leu Glu Pro Leu Leu Ala Pro Lys Phe Gln Ala Ile Ala Pro 
            740                 745                 750         


Leu Thr Val Pro Arg Tyr Gln Lys Phe Pro Leu Gly Asp Gly Ser Ser 
        755                 760                 765             


Leu Leu Leu Ala Asp Thr Leu Gln Thr His Ser Ser Leu Phe Leu Glu 
    770                 775                 780                 


Glu Leu Glu Met Leu Val Pro Ser Thr Pro Thr Ser Thr Ser Gly Ala 
785                 790                 795                 800 


Phe Trp Lys Gly Ser Glu Leu Ala Thr Asp Pro Pro Ala Gln Pro Ala 
                805                 810                 815     


Ala Pro Ser Thr Thr Ser Glu Val Val Lys Ile Leu Glu Arg Trp Trp 
            820                 825                 830         


Gly Thr Lys Arg Ile Asp Tyr Ser Leu Tyr Cys Pro Glu Ala Leu Thr 
        835                 840                 845             


Ala Phe Pro Thr Val Thr Leu Pro His Leu Phe His Ala Ser Tyr Trp 
    850                 855                 860                 


Glu Ser Ala Asp Val Val Ala Phe Ile Leu Arg Gln Val Ile Glu Lys 
865                 870                 875                 880 


Glu Arg Pro Gln Leu Ala Glu Cys Glu Glu Pro Ser Ile Tyr Ser Pro 
                885                 890                 895     


Ala Phe Pro Arg Glu Lys Trp Gln Arg Lys Arg Thr Gln Val Lys Ile 
            900                 905                 910         


Arg Asn Val Thr Ser Asn His Arg Ala Ser Asp Thr Val Val Cys Glu 
        915                 920                 925             


Gly Arg Pro Gln Val Leu Ser Gly Arg Phe Met Tyr Gly Pro Leu Asp 
    930                 935                 940                 


Val Val Thr Leu Thr Gly Glu Lys Val Asp Val Tyr Ile Met Thr Gln 
945                 950                 955                 960 


Pro Leu Ser Gly Lys Trp Ile His Phe Gly Thr Glu Val Thr Asn Ser 
                965                 970                 975     


Ser Gly Arg Leu Thr Phe Pro Val Pro Pro Glu Arg Ala Leu Gly Ile 
            980                 985                 990         


Gly Val Tyr Pro Val Arg Met Val  Val Arg Gly Asp His  Thr Tyr Ala 
        995                 1000                 1005             


Glu Cys  Cys Leu Thr Val Val  Ala Arg Gly Thr Glu  Ala Val Val 
    1010                 1015                 1020             


Phe Ser  Ile Asp Gly Ser Phe  Thr Ala Ser Val Ser  Ile Met Gly 
    1025                 1030                 1035             


Ser Asp  Pro Lys Val Arg Ala  Gly Ala Val Asp Val  Val Arg His 
    1040                 1045                 1050             


Trp Gln  Asp Ser Gly Tyr Leu  Ile Val Tyr Val Thr  Gly Arg Pro 
    1055                 1060                 1065             


Asp Met  Gln Lys His Arg Val  Val Ala Trp Leu Ser  Gln His Asn 
    1070                 1075                 1080             


Phe Pro  His Gly Val Val Ser  Phe Cys Asp Gly Leu  Thr His Asp 
    1085                 1090                 1095             


Pro Leu  Arg Gln Lys Ala Met  Phe Leu Gln Ser Leu  Val Gln Glu 
    1100                 1105                 1110             


Val Glu  Leu Asn Ile Val Ala  Gly Tyr Gly Ser Pro  Lys Asp Val 
    1115                 1120                 1125             


Ala Val  Tyr Ala Ala Leu Gly  Leu Ser Pro Ser Gln  Thr Tyr Ile 
    1130                 1135                 1140             


Val Gly  Arg Ala Val Arg Lys  Leu Gln Ala Gln Cys  Gln Phe Leu 
    1145                 1150                 1155             


Ser Asp  Gly Tyr Val Ala His  Leu Gly Gln Leu Glu  Ala Gly Ser 
    1160                 1165                 1170             


His Ser  His Ala Ser Ser Gly  Pro Pro Arg Ala Ala  Leu Gly Lys 
    1175                 1180                 1185             


Ser Ser  Tyr Gly Val Ala Ala  Pro Val Asp Phe Leu  Arg Lys Gln 
    1190                 1195                 1200             


Ser Gln  Leu Leu Arg Ser Arg  Gly Pro Ser Gln Ala  Glu Arg Glu 
    1205                 1210                 1215             


Gly Pro  Gly Thr Pro Pro Thr  Thr Leu Ala Arg Gly  Lys Ala Arg 
    1220                 1225                 1230             


Ser Ile  Ser Leu Lys Leu Asp  Ser Glu Glu 
    1235                 1240             


<210> 7741
<211> 537
<212> PRT
<213> Homo sapiens

<400> 7741
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 
        35                  40                  45              


Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 
65                  70                  75                  80  


Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 
                85                  90                  95      


Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 
            100                 105                 110         


Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro 
        115                 120                 125             


Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys 
    130                 135                 140                 


Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile 
145                 150                 155                 160 


Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu 
                165                 170                 175     


Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile 
            180                 185                 190         


Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln 
        195                 200                 205             


Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser 
    210                 215                 220                 


Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr 
225                 230                 235                 240 


Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly 
                245                 250                 255     


Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr 
            260                 265                 270         


Lys Val Tyr His Glu Asn Ile Lys Thr Gly Val Pro Ala Arg Arg Met 
        275                 280                 285             


Met Lys Asn Gln Val Met Arg Lys Lys Leu Ile Leu Phe Phe Lys Arg 
    290                 295                 300                 


Arg Asn His Ala Arg Lys Gln Arg Glu Gln Lys Ile Cys Gln Arg Tyr 
305                 310                 315                 320 


Asp Gln Leu Met Glu Ala Trp Glu Lys Lys Val Asp Arg Ile Glu Asn 
                325                 330                 335     


Asn Pro Arg Arg Lys Ala Lys Glu Ser Lys Thr Arg Glu Tyr Tyr Glu 
            340                 345                 350         


Lys Gln Phe Pro Glu Ile Arg Lys Gln Arg Glu Gln Gln Glu Arg Phe 
        355                 360                 365             


Gln Arg Val Gly Gln Arg Gly Ala Gly Leu Ser Ala Thr Ile Ala Arg 
    370                 375                 380                 


Ser Glu His Glu Ile Ser Glu Ile Ile Asp Gly Leu Ser Glu Gln Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Gln Met Arg Gln Leu Ser Val Ile Pro Pro Met Met 
                405                 410                 415     


Phe Asp Ala Glu Gln Arg Arg Val Lys Phe Ile Asn Met Asn Gly Leu 
            420                 425                 430         


Met Glu Asp Pro Met Lys Val Tyr Lys Asp Arg Gln Phe Met Asn Val 
        435                 440                 445             


Trp Thr Asp His Glu Lys Glu Ile Phe Lys Asp Lys Phe Ile Gln His 
    450                 455                 460                 


Pro Lys Asn Phe Gly Leu Ile Ala Ser Tyr Leu Glu Arg Lys Ser Val 
465                 470                 475                 480 


Pro Asp Cys Val Leu Tyr Tyr Tyr Leu Thr Lys Lys Asn Glu Asn Tyr 
                485                 490                 495     


Lys Ala Leu Val Arg Arg Asn Tyr Gly Lys Arg Arg Gly Arg Asn Gln 
            500                 505                 510         


Gln Ile Ala Arg Pro Ser Gln Glu Glu Lys Val Glu Glu Lys Glu Glu 
        515                 520                 525             


Asp Lys Ala Glu Lys Thr Glu Lys Lys 
    530                 535         


<210> 7742
<211> 48
<212> PRT
<213> Homo sapiens

<400> 7742
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Gln Leu Leu Leu Leu Met 
        35                  40                  45              


<210> 7743
<211> 265
<212> PRT
<213> Homo sapiens

<400> 7743
Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg 
        115                 120                 125             


Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser 
    130                 135                 140                 


Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala 
145                 150                 155                 160 


Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys 
                165                 170                 175     


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
            180                 185                 190         


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
        195                 200                 205             


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
    210                 215                 220                 


Ser Arg Glu Pro Ala Ile Arg Lys Arg Leu Lys Asn Cys Pro Pro Leu 
225                 230                 235                 240 


Arg Ile Trp Thr Phe Ser Thr Arg Thr Arg Lys Tyr Ile Leu Val Lys 
                245                 250                 255     


Arg Arg Arg Lys Tyr Phe Trp Arg Ser 
            260                 265 


<210> 7744
<211> 153
<212> PRT
<213> Homo sapiens

<400> 7744
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 
            20                  25                  30          


Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu 
145                 150             


<210> 7745
<211> 25
<212> PRT
<213> Homo sapiens

<400> 7745
Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser 
1               5                   10                  15      


Gly Asn Leu Ala His Val Glu Lys Val 
            20                  25  


<210> 7746
<211> 75
<212> PRT
<213> Homo sapiens

<400> 7746
Met Ala Ser Glu Val Gly His Asn Leu Glu Ser Pro Glu Thr Pro Gly 
1               5                   10                  15      


Gly Gly Gly Trp Thr Arg Val Glu Phe Pro Pro Pro Ala Pro Lys Gly 
            20                  25                  30          


Ala Ala Thr Val Trp Cys Leu Asn Arg Leu Gly Ser Arg Lys Leu Ser 
        35                  40                  45              


Leu Ile Trp Ile Thr Phe Asn Thr Gly Trp Asn Met Lys Ser Arg Leu 
    50                  55                  60                  


Ile Ile Leu Ile Gln Gln Val Ser Cys His His 
65                  70                  75  


<210> 7747
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7747
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7748
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7748
Met Pro Gly Leu Ser Cys Arg Phe Tyr Gln His Lys Phe Pro Glu Val 
1               5                   10                  15      


Glu Asp Val Val Met Val Asn Val Arg Ser Ile Ala Glu Met Gly Ala 
            20                  25                  30          


Tyr Val Ser Leu Leu Glu Tyr Asn Asn Ile Glu Gly Met Ile Leu Leu 
        35                  40                  45              


Ser Glu Leu Ser Arg Arg Arg Ile Arg Ser Ile Asn Lys Leu Ile Arg 
    50                  55                  60                  


Ile Gly Arg Asn Glu Cys Val Val Val Ile Arg Val Asp Lys Glu Lys 
65                  70                  75                  80  


Gly Tyr Ile Asp Leu Ser Lys Arg Arg Leu Thr Leu Trp Glu Thr Glu 
                85                  90                  95      


Ser Asn Leu Arg Asn Thr Glu Gln Arg Phe Leu Ala Val Asn Pro Arg 
            100                 105                 110         


Leu Glu Ser Phe Pro Val Leu Lys Thr Ser Lys Leu Asn Ile Phe Tyr 
        115                 120                 125             


Phe 
    


<210> 7749
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7749
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 7750
<211> 660
<212> PRT
<213> Homo sapiens

<400> 7750
Ile Ala Lys Pro Gln Gly Thr Tyr Gln Val Leu Pro Pro Asn Thr Gly 
1               5                   10                  15      


Ser Leu Tyr Ile Asp Lys Asp Cys Ser Ala Val Tyr Cys His Glu Ser 
            20                  25                  30          


Ser Ser Asn Ile Tyr Tyr Pro Phe Gln Lys Arg Glu Gln Leu Arg Ala 
        35                  40                  45              


Gly Arg Tyr Ile Met Arg His Thr Ser Glu Val Ile Cys Glu Val Leu 
    50                  55                  60                  


Asp Pro Glu Gly Asn Thr Phe Gln Val Met Ala Asp Gly Ser Ile Ser 
65                  70                  75                  80  


Thr Ile Leu Pro Glu Lys Lys Leu Glu Asp Asp Leu Asn Glu Lys Thr 
                85                  90                  95      


Glu Gly Tyr Asp Ser Leu Ser Ser Met His Leu Glu Lys Asn His Gln 
            100                 105                 110         


Gln Ile Tyr Gly Glu His Val Pro Arg Phe Phe Val Met Tyr Ala Asp 
        115                 120                 125             


Gly Ser Gly Met Glu Leu Leu Arg Asp Ser Asp Ile Glu Glu Tyr Leu 
    130                 135                 140                 


Ser Leu Ala Tyr Lys Glu Ser Asn Thr Val Val Leu Gln Glu Pro Val 
145                 150                 155                 160 


Gln Glu Gln Pro Gly Thr Leu Thr Ile Thr Val Leu Arg Pro Phe His 
                165                 170                 175     


Glu Ala Ser Pro Trp Gln Val Lys Lys Glu Asp Thr Ile Val Pro Pro 
            180                 185                 190         


Asn Leu Arg Ser Arg Ser Trp Glu Thr Phe Pro Ser Val Glu Lys Lys 
        195                 200                 205             


Thr Pro Gly Pro Pro Phe Gly Thr Gln Ile Trp Lys Gly Leu Cys Ile 
    210                 215                 220                 


Glu Ser Lys Gln Leu Val Ser Ala Pro Gly Ala Ile Leu Lys Ser Pro 
225                 230                 235                 240 


Ser Val Leu Gln Met Arg Gln Phe Ile Gln His Glu Val Ile Lys Asn 
                245                 250                 255     


Glu Val Lys Leu Arg Leu Gln Val Ser Leu Lys Asp Tyr Ile Asn Tyr 
            260                 265                 270         


Ile Leu Lys Lys Glu Asp Glu Leu Gln Glu Met Met Val Lys Asp Ser 
        275                 280                 285             


Arg Thr Glu Glu Glu Arg Gly Asn Ala Ala Asp Leu Leu Lys Leu Val 
    290                 295                 300                 


Met Ser Phe Pro Lys Met Glu Glu Thr Thr Lys Ser His Val Thr Glu 
305                 310                 315                 320 


Val Ala Ala His Leu Thr Asp Leu Phe Lys Gln Ser Leu Ala Thr Pro 
                325                 330                 335     


Pro Lys Cys Pro Pro Asp Thr Phe Gly Lys Asp Phe Phe Glu Lys Thr 
            340                 345                 350         


Trp Arg His Thr Ala Ser Ser Lys Arg Trp Lys Glu Lys Ile Asp Lys 
        355                 360                 365             


Thr Arg Lys Glu Ile Glu Thr Thr Gln Asn Tyr Leu Met Asp Ile Lys 
    370                 375                 380                 


Asn Arg Ile Ile Pro Pro Phe Phe Lys Ser Glu Leu Asn Gln Leu Tyr 
385                 390                 395                 400 


Gln Ser Gln Tyr Asn His Leu Asp Ser Leu Ser Lys Lys Leu Pro Ser 
                405                 410                 415     


Phe Thr Lys Lys Asn Glu Asp Ala Asn Glu Thr Ala Val Gln Asp Thr 
            420                 425                 430         


Ser Asp Leu Asn Leu Asp Phe Lys Pro His Lys Val Ser Glu Gln Lys 
        435                 440                 445             


Ser Ser Ser Val Pro Ser Leu Pro Lys Pro Glu Ile Ser Ala Asp Lys 
    450                 455                 460                 


Lys Asp Phe Thr Ala Gln Asn Gln Thr Glu Asn Leu Thr Lys Ser Pro 
465                 470                 475                 480 


Glu Glu Ala Glu Ser Tyr Glu Pro Val Lys Ile Pro Thr Gln Ser Leu 
                485                 490                 495     


Leu Gln Asp Val Ala Gly Gln Thr Arg Lys Glu Lys Val Lys Leu Pro 
            500                 505                 510         


His Tyr Leu Leu Ser Ser Lys Pro Lys Ser Gln Pro Leu Ala Lys Val 
        515                 520                 525             


Gln Asp Ser Val Gly Gly Lys Val Asn Thr Ser Ser Val Ala Ser Ala 
    530                 535                 540                 


Ala Ile Asn Asn Ala Lys Ser Ser Leu Phe Gly Phe His Leu Leu Pro 
545                 550                 555                 560 


Ser Ser Val Lys Phe Gly Val Leu Lys Glu Gly His Thr Tyr Ala Thr 
                565                 570                 575     


Val Val Lys Leu Lys Asn Val Gly Val Asp Phe Cys Arg Phe Lys Val 
            580                 585                 590         


Lys Gln Pro Pro Pro Ser Thr Gly Leu Lys Val Thr Tyr Lys Pro Gly 
        595                 600                 605             


Pro Val Ala Ala Gly Met Gln Thr Glu Leu Asn Ile Glu Leu Phe Ala 
    610                 615                 620                 


Thr Ala Val Gly Glu Asp Gly Ala Lys Gly Ser Ala His Ile Ser His 
625                 630                 635                 640 


Asn Ile Glu Ile Met Thr Glu His Glu Val Leu Phe Leu Pro Val Glu 
                645                 650                 655     


Ala Asn Ile Leu 
            660 


<210> 7751
<211> 824
<212> PRT
<213> Homo sapiens

<400> 7751
Met Tyr Ser Asn Glu Asp Ser Arg Gln Thr Ile Val Tyr Ser Glu Glu 
1               5                   10                  15      


Ser Asn Thr Thr Met Ser Tyr Thr Gln Lys Ile Thr Asn Pro Leu Pro 
            20                  25                  30          


Ala Ala Ser Ser Thr Asp Pro Ala Pro Phe Ala Asn Ile Asn Thr Pro 
        35                  40                  45              


Val Leu Gln Glu Asp Tyr Arg Gln Asp Ser Gln Thr Arg Arg Ile Ser 
    50                  55                  60                  


Thr Leu Lys Leu Thr His Asn Gln Asp Leu Gly Ser Ser Ser Pro Ile 
65                  70                  75                  80  


Ser Thr Pro Gln Phe Ser Lys Ser Val Glu Val Pro Ser Phe Leu Lys 
                85                  90                  95      


Arg Pro Arg Ser Leu Thr Pro Asn Pro Val Pro Glu Thr His Thr Ala 
            100                 105                 110         


Ser Leu Ser Ile Gln Ile Ala Pro Leu Ser Gly Gln Asp Leu Glu Ser 
        115                 120                 125             


His Lys Gln Leu Pro Glu Leu Ser Pro Glu Thr Ala Lys Ile Pro Leu 
    130                 135                 140                 


Gln Gln Glu Arg Gln Lys Ser Ala Val Ala Ala Ala Ser Gln Ser Ser 
145                 150                 155                 160 


Asp Cys Arg Val Ser Gln Ile Thr Val Asn Gly Asn Ser Gly Gly Ala 
                165                 170                 175     


Val Ser Pro Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr 
            180                 185                 190         


Ser Leu Pro Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr 
        195                 200                 205             


Ser Leu Asp Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp 
    210                 215                 220                 


Gly Thr Thr Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu 
225                 230                 235                 240 


Lys Arg Val Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro 
                245                 250                 255     


Val Asp Glu Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg 
            260                 265                 270         


Pro Lys Asp Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His 
        275                 280                 285             


Lys Pro Asp Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn 
    290                 295                 300                 


Ala Gly Leu Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala 
305                 310                 315                 320 


Lys Thr Gln Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser 
                325                 330                 335     


Pro Asn Ala Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val 
            340                 345                 350         


Pro Pro Pro Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu 
        355                 360                 365             


Lys His Asp Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe 
    370                 375                 380                 


Arg Ser Glu Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser 
385                 390                 395                 400 


Ile Leu Gln His Glu Arg Pro Pro Pro Leu Pro Thr Thr Pro Thr Pro 
                405                 410                 415     


Val Pro Arg Glu Pro Gly Arg Lys Pro Leu Ser Ser Ser Arg Leu Gly 
            420                 425                 430         


Glu Val Thr Gly Ser Pro Ser Pro Pro Pro Arg Ser Gly Ala Pro Thr 
        435                 440                 445             


Pro Ser Ser Arg Ala Pro Ala Leu Ser Pro Thr Arg Pro Pro Lys Lys 
    450                 455                 460                 


Pro Leu Asp Tyr Val Gln Asp His Ser Ser Gly Val Phe Asn Glu Ala 
465                 470                 475                 480 


Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu Glu Arg Pro Met Ser 
                485                 490                 495     


Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg Arg Lys Ser Glu Pro 
            500                 505                 510         


Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln Ser Ala Ser Arg Thr 
        515                 520                 525             


Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser Thr Thr Leu Thr Lys 
    530                 535                 540                 


Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser Arg Ala Lys Asp Arg 
545                 550                 555                 560 


Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp Met Gly Arg Ser 
                565                 570                 575     


Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu Lys Leu Pro Ala 
            580                 585                 590         


Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys Glu Leu Ser Phe 
        595                 600                 605             


Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile Asp Gln Asn Trp 
    610                 615                 620                 


Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe Pro Ile Ser Tyr 
625                 630                 635                 640 


Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro Ala Arg Pro Pro 
                645                 650                 655     


Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile Ala Lys Tyr Asn 
            660                 665                 670         


Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg Lys Gly Asp Arg 
        675                 680                 685             


Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr Glu Gly Lys Ile 
    690                 695                 700                 


Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser Tyr Val Glu Val 
705                 710                 715                 720 


Val Lys Lys Asn Thr Lys Gly Ala Glu Asp Tyr Pro Asp Pro Pro Ile 
                725                 730                 735     


Pro His Ser Tyr Ser Ser Asp Arg Ile His Ser Leu Ser Ser Asn Lys 
            740                 745                 750         


Pro Gln Arg Pro Val Phe Thr His Glu Asn Ile Gln Gly Gly Gly Glu 
        755                 760                 765             


Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn Glu Asp Glu Leu 
    770                 775                 780                 


Glu Leu Arg Glu Ser Asp Val Ile Asp Val Met Glu Lys Cys Asp Asp 
785                 790                 795                 800 


Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe Phe Gly Thr Phe 
                805                 810                 815     


Pro Gly Asn Tyr Val Lys Arg Leu 
            820                 


<210> 7752
<211> 75
<212> PRT
<213> Homo sapiens

<400> 7752
Met Arg Tyr Tyr Gly Ser Tyr Tyr Arg Gly Leu Gly Tyr Gly Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Cys Gly Cys Gly Gly Tyr Arg Tyr 
            20                  25                  30          


Gly Ser Gly Tyr Gly Gly Tyr Arg Tyr Gly Cys Cys Arg Pro Ser Cys 
        35                  40                  45              


Arg Glu Gly Tyr Gly Phe Ser Gly Phe Lys Lys Leu Ala Asp Ser His 
    50                  55                  60                  


Thr Leu Thr Pro Arg Ser Cys Pro Tyr Ala Ser 
65                  70                  75  


<210> 7753
<211> 60
<212> PRT
<213> Homo sapiens

<400> 7753
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg 
    50                  55                  60  


<210> 7754
<211> 199
<212> PRT
<213> Homo sapiens

<400> 7754
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Ser Phe Pro Leu Lys Gln 
        115                 120                 125             


Val Ala Arg Glu Ser Gly Pro Pro His Met Lys Asn Phe Val Thr Lys 
    130                 135                 140                 


Val Ser Val Gly Glu Phe Val Gly Glu Gly Glu Gly Lys Ser Lys Lys 
145                 150                 155                 160 


Ile Ser Lys Lys Asn Ala Ala Ile Ala Val Leu Glu Glu Leu Lys Lys 
                165                 170                 175     


Leu Pro Pro Leu Pro Ala Val Glu Arg Val Lys Pro Arg Ile Lys Lys 
            180                 185                 190         


Lys Thr Lys Pro Ile Val Lys 
        195                 


<210> 7755
<211> 894
<212> PRT
<213> Homo sapiens

<400> 7755
Met Pro Glu Gln Phe Ser Val Ala Glu Phe Leu Ala Val Thr Ala Glu 
1               5                   10                  15      


Asp Leu Ser Ser Pro Ala Gly Ala Ala Ala Phe Ala Ala Lys Met Pro 
            20                  25                  30          


Arg Tyr Arg Gly Ala Ala Leu Ala Arg Glu Glu Ile Leu Glu Gly Asp 
        35                  40                  45              


Gln Ala Ile Leu Gln Arg Ile Lys Lys Ala Val Arg Ala Ile His Ser 
    50                  55                  60                  


Ser Gly Leu Gly His Val Glu Asn Glu Glu Gln Tyr Arg Glu Ala Val 
65                  70                  75                  80  


Glu Ser Leu Gly Asn Ser His Leu Ser Gln Asn Ser His Glu Leu Ser 
                85                  90                  95      


Thr Gly Phe Leu Asn Leu Ala Val Phe Thr Arg Glu Val Ala Ala Leu 
            100                 105                 110         


Phe Lys Asn Leu Ile Gln Asn Leu Asn Asn Ile Val Ser Phe Pro Leu 
        115                 120                 125             


Asp Ser Leu Met Lys Gly Gln Leu Arg Asp Gly Arg Gln Ala Ser Leu 
    130                 135                 140                 


Ser Leu Gly Ser Arg Ala Lys Leu Glu Lys Glu Arg Asp Arg Ala Arg 
145                 150                 155                 160 


Val Thr Gly Gly Ile Pro Gly Glu Val Ala Gln Asp Met Gln Arg Glu 
                165                 170                 175     


Arg Arg Ile Phe Gln Leu His Met Cys Glu Tyr Leu Leu Lys Ala Gly 
            180                 185                 190         


Glu Ser Gln Met Lys Gln Gly Pro Asp Phe Leu Gln Ser Leu Ile Lys 
        195                 200                 205             


Phe Phe His Ala Gln His Asn Phe Phe Gln Asp Gly Trp Lys Ala Ala 
    210                 215                 220                 


Gln Ser Leu Phe Pro Phe Ile Glu Lys Leu Ala Ala Ser Val His Ala 
225                 230                 235                 240 


Leu His Gln Ala Gln Glu Asp Glu Leu Gln Lys Leu Thr Gln Leu Arg 
                245                 250                 255     


Asp Ser Leu Arg Gly Thr Leu Gln Leu Glu Ser Arg Glu Glu His Leu 
            260                 265                 270         


Ser Arg Lys Asn Ser Gly Cys Gly Tyr Ser Ile His Gln His Gln Gly 
        275                 280                 285             


Asn Lys Gln Phe Gly Thr Glu Lys Val Gly Phe Leu Tyr Lys Lys Ser 
    290                 295                 300                 


Asp Gly Ile Arg Arg Val Trp Gln Lys Arg Lys Cys Gly Val Lys Tyr 
305                 310                 315                 320 


Gly Cys Leu Thr Ile Ser His Ser Thr Ile Asn Arg Pro Pro Val Lys 
                325                 330                 335     


Leu Thr Leu Leu Thr Cys Gln Val Arg Pro Asn Pro Glu Glu Lys Lys 
            340                 345                 350         


Cys Phe Asp Leu Val Thr His Asn Arg Thr Tyr His Phe Gln Ala Glu 
        355                 360                 365             


Asp Glu His Glu Cys Glu Ala Trp Val Ser Val Leu Gln Asn Ser Lys 
    370                 375                 380                 


Asp Glu Ala Leu Ser Ser Ala Phe Leu Gly Glu Pro Ser Ala Gly Pro 
385                 390                 395                 400 


Gly Ser Trp Gly Ser Ala Gly His Asp Gly Glu Pro His Asp Leu Thr 
                405                 410                 415     


Lys Leu Leu Ile Ala Glu Val Lys Ser Arg Pro Gly Asn Ser Gln Cys 
            420                 425                 430         


Cys Asp Cys Gly Ala Ala Asp Pro Thr Trp Leu Ser Thr Asn Leu Gly 
        435                 440                 445             


Val Leu Thr Cys Ile Gln Cys Ser Gly Val His Arg Glu Leu Gly Val 
    450                 455                 460                 


Arg Phe Ser Arg Met Gln Ser Leu Thr Leu Asp Leu Leu Gly Pro Ser 
465                 470                 475                 480 


Glu Leu Leu Leu Ala Leu Asn Met Gly Asn Thr Ser Phe Asn Glu Val 
                485                 490                 495     


Met Glu Ala Gln Leu Pro Ser His Gly Gly Pro Lys Pro Ser Ala Glu 
            500                 505                 510         


Ser Asp Met Gly Thr Arg Arg Asp Tyr Ile Met Ala Lys Tyr Val Glu 
        515                 520                 525             


His Arg Phe Ala Arg Arg Cys Thr Pro Glu Pro Gln Arg Leu Trp Thr 
    530                 535                 540                 


Ala Ile Cys Asn Arg Asp Leu Leu Ser Val Leu Glu Ala Phe Ala Asn 
545                 550                 555                 560 


Gly Gln Asp Phe Gly Gln Pro Leu Pro Gly Pro Asp Ala Gln Ala Pro 
                565                 570                 575     


Glu Glu Leu Val Leu His Leu Ala Val Lys Val Ala Asn Gln Ala Ser 
            580                 585                 590         


Leu Pro Leu Val Asp Phe Ile Ile Gln Asn Gly Gly His Leu Asp Ala 
        595                 600                 605             


Lys Ala Ala Asp Gly Asn Thr Ala Leu His Tyr Ala Ala Leu Tyr Asn 
    610                 615                 620                 


Gln Pro Asp Cys Leu Lys Leu Leu Leu Lys Gly Arg Ala Leu Val Gly 
625                 630                 635                 640 


Thr Val Asn Glu Ala Gly Glu Thr Ala Leu Asp Ile Ala Arg Lys Lys 
                645                 650                 655     


His His Lys Glu Cys Glu Glu Leu Leu Glu Gln Ala Gln Ala Gly Thr 
            660                 665                 670         


Phe Ala Phe Pro Leu His Val Asp Tyr Ser Trp Val Ile Ser Thr Glu 
        675                 680                 685             


Pro Gly Ser Asp Ser Glu Glu Asp Glu Glu Glu Lys Arg Cys Leu Leu 
    690                 695                 700                 


Lys Leu Pro Ala Gln Ala His Trp Ala Ser Gly Arg Leu Asp Ile Ser 
705                 710                 715                 720 


Asn Lys Thr Tyr Glu Thr Val Ala Ser Leu Gly Ala Ala Thr Pro Gln 
                725                 730                 735     


Gly Glu Ser Glu Asp Cys Pro Pro Pro Leu Pro Val Lys Asn Ser Ser 
            740                 745                 750         


Arg Thr Leu Val Gln Gly Cys Ala Arg His Ala Ser Gly Asp Arg Ser 
        755                 760                 765             


Glu Val Ser Ser Leu Ser Ser Glu Ala Pro Glu Thr Pro Glu Ser Leu 
    770                 775                 780                 


Gly Ser Pro Ala Ser Ser Ser Ser Leu Met Ser Pro Leu Glu Pro Gly 
785                 790                 795                 800 


Asp Pro Ser Gln Ala Pro Pro Asn Ser Glu Glu Gly Leu Arg Glu Pro 
                805                 810                 815     


Pro Gly Thr Ser Arg Pro Ser Leu Thr Ser Gly Thr Thr Pro Ser Glu 
            820                 825                 830         


Met Tyr Leu Pro Val Arg Phe Ser Ser Glu Ser Thr Arg Ser Tyr Arg 
        835                 840                 845             


Arg Gly Ala Arg Ser Pro Glu Asp Gly Pro Ser Ala Arg Gln Pro Leu 
    850                 855                 860                 


Pro Arg Arg Asn Val Pro Val Gly Ile Thr Glu Gly Asp Gly Ser Arg 
865                 870                 875                 880 


Thr Gly Ser Leu Pro Ala Ser Ser Val Gln Leu Leu Gln Asp 
                885                 890                 


<210> 7756
<211> 117
<212> PRT
<213> Homo sapiens

<400> 7756
Met Ala Phe Ser Gly Arg Ala Arg Pro Cys Ile Ile Pro Glu Asn Glu 
1               5                   10                  15      


Glu Ile Pro Arg Ala Ala Leu Asn Thr Val His Glu Ala Asn Gly Thr 
            20                  25                  30          


Glu Asp Glu Arg Ala Val Ser Lys Leu Gln Arg Arg His Ser Asp Val 
        35                  40                  45              


Lys Val Tyr Lys Glu Phe Cys Asp Phe Tyr Ala Lys Phe Asn Met Ala 
    50                  55                  60                  


Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly Phe Ala 
65                  70                  75                  80  


Pro Ala Glu Thr Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu Gln 
                85                  90                  95      


Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly Leu Phe 
            100                 105                 110         


Tyr Glu Glu Arg Thr 
        115         


<210> 7757
<211> 598
<212> PRT
<213> Homo sapiens

<400> 7757
Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Ser Gly Ser Gly Ser Glu Pro Val Ala Ala Ala Leu 
            180                 185                 190         


Glu Lys Ser Ser Arg Leu Phe Ala Gly Pro Met Ser Asp Arg Thr Ala 
        195                 200                 205             


Pro Arg Ser Pro Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
    210                 215                 220                 


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
225                 230                 235                 240 


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
                245                 250                 255     


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
            260                 265                 270         


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
        275                 280                 285             


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
    290                 295                 300                 


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
305                 310                 315                 320 


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
                325                 330                 335     


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
            340                 345                 350         


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
        355                 360                 365             


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
    370                 375                 380                 


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
385                 390                 395                 400 


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
                405                 410                 415     


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
            420                 425                 430         


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
        435                 440                 445             


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
    450                 455                 460                 


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
465                 470                 475                 480 


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
                485                 490                 495     


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
            500                 505                 510         


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
        515                 520                 525             


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
    530                 535                 540                 


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
545                 550                 555                 560 


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
                565                 570                 575     


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
            580                 585                 590         


Leu Ile Ser Leu Leu Ser 
        595             


<210> 7758
<211> 997
<212> PRT
<213> Homo sapiens

<400> 7758
Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile Ser Phe 
1               5                   10                  15      


Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser Arg Ile 
            20                  25                  30          


Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu Arg Trp 
        35                  40                  45              


Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile Ser Ala 
    50                  55                  60                  


Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Arg Asn Asn 
65                  70                  75                  80  


Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile Leu His 
                85                  90                  95      


Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala Asp Val 
            100                 105                 110         


Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg Ser Lys 
        115                 120                 125             


Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg Phe Met 
    130                 135                 140                 


Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn Gly Ile 
145                 150                 155                 160 


Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn Pro Thr 
                165                 170                 175     


Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln Lys Ser 
            180                 185                 190         


Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys Glu Ala 
        195                 200                 205             


Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu Val Gln 
    210                 215                 220                 


Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met Leu Phe 
225                 230                 235                 240 


Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile Cys Leu 
                245                 250                 255     


Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln Lys Gly 
            260                 265                 270         


Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser Glu Cys 
        275                 280                 285             


Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met Thr Gln 
    290                 295                 300                 


Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr Leu Ile 
305                 310                 315                 320 


Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile Arg Ala 
                325                 330                 335     


Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp Gly Ser 
            340                 345                 350         


Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr His Val 
        355                 360                 365             


Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe Val Ala 
    370                 375                 380                 


Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser Leu Pro 
385                 390                 395                 400 


Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly Asn Lys 
                405                 410                 415     


Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro Ser Pro 
            420                 425                 430         


Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu Pro Ser 
        435                 440                 445             


Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu Glu Ala 
    450                 455                 460                 


Glu Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln Lys Gln 
465                 470                 475                 480 


Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys Lys Ser 
                485                 490                 495     


Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn Tyr Trp 
            500                 505                 510         


Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala Asn Glu 
        515                 520                 525             


Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser Arg Ile 
    530                 535                 540                 


Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro Gln Asp 
545                 550                 555                 560 


Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln Thr Pro 
                565                 570                 575     


Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn Gly Gly 
            580                 585                 590         


Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val Ser Tyr 
        595                 600                 605             


Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro Leu Ala 
    610                 615                 620                 


Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro Lys Gly 
625                 630                 635                 640 


Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile Glu Ile 
                645                 650                 655     


His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr Val Gln 
            660                 665                 670         


Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe Gln Val 
        675                 680                 685             


Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp Asp Asp 
    690                 695                 700                 


Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe Glu Cys 
705                 710                 715                 720 


Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val Gly Asp 
                725                 730                 735     


Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr Asn Arg 
            740                 745                 750         


Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg Met Gly 
        755                 760                 765             


Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu Lys Thr 
    770                 775                 780                 


Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu Ala Ile 
785                 790                 795                 800 


Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys Glu Leu 
                805                 810                 815     


Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu Thr Leu 
            820                 825                 830         


Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser Leu Val 
        835                 840                 845             


Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile Pro Asp 
    850                 855                 860                 


Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln Glu Ser 
865                 870                 875                 880 


Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile Val Gln 
                885                 890                 895     


Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His Asn Leu Gly 
            900                 905                 910         


Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala Thr Glu Ser 
        915                 920                 925             


Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp Leu Leu Lys 
    930                 935                 940                 


Asn Ala Lys Asn Glu Ala Ile Glu Asn Met Lys Gln Ile Gln Leu Ala 
945                 950                 955                 960 


Cys Leu Ser Cys Gly Leu Ser Lys Ala Pro Ser Ser Ser Ala Glu Ala 
                965                 970                 975     


Lys Ser Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu Ser Ser Glu 
            980                 985                 990         


Glu Asn Gly Lys Leu 
        995         


<210> 7759
<211> 203
<212> PRT
<213> Homo sapiens

<400> 7759
Met Arg Asn Gly Asp Phe Leu Pro Thr Arg Leu Gln Ala Gln Gln Asp 
1               5                   10                  15      


Ala Val Asn Ile Val Cys His Ser Lys Thr Arg Ser Asn Pro Glu Asn 
            20                  25                  30          


Asn Val Gly Leu Ile Thr Leu Ala Asn Asp Cys Glu Val Leu Thr Thr 
        35                  40                  45              


Leu Thr Pro Asp Thr Gly Arg Ile Leu Ser Lys Leu His Thr Val Gln 
    50                  55                  60                  


Pro Lys Gly Lys Ile Thr Phe Cys Thr Gly Ile Arg Val Ala His Leu 
65                  70                  75                  80  


Ala Leu Lys His Arg Gln Gly Lys Asn His Lys Met Arg Ile Ile Ala 
                85                  90                  95      


Phe Val Gly Ser Pro Val Glu Asp Asn Glu Lys Asp Leu Val Lys Leu 
            100                 105                 110         


Ala Lys Arg Leu Lys Lys Glu Lys Val Asn Val Asp Ile Ile Asn Phe 
        115                 120                 125             


Gly Glu Glu Glu Val Asn Thr Glu Lys Leu Thr Ala Phe Val Asn Thr 
    130                 135                 140                 


Leu Asn Gly Lys Asp Gly Thr Gly Ser His Leu Val Thr Val Pro Pro 
145                 150                 155                 160 


Gly Pro Ser Leu Ala Asp Ala Leu Ile Ser Ser Pro Ile Leu Ala Gly 
                165                 170                 175     


Glu Gly Gly Ala Met Leu Gly Leu Gly Ala Ser Asp Phe Glu Phe Gly 
            180                 185                 190         


Val Asp Pro Ser Ala Asp Pro Glu Leu Ala Leu 
        195                 200             


<210> 7760
<211> 142
<212> PRT
<213> Homo sapiens

<400> 7760
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln Thr Arg Gln 
                85                  90                  95      


Gln Ala Tyr Arg Asp Lys Leu Ala Gln Gln Gln Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ser Gln Gln Gly Ser Ala Lys Asn Gly Glu 
        115                 120                 125             


Asn Thr Ala Asn Gly Glu Glu Asn Gly Ala His Thr Ile Ala 
    130                 135                 140         


<210> 7761
<211> 469
<212> PRT
<213> Homo sapiens

<400> 7761
Met Cys Ser Leu Ala Ser Gly Ala Thr Gly Tyr Ser His Leu Leu Lys 
1               5                   10                  15      


Lys His Phe His Thr Val Ser Leu Ser Ile Ser Leu Ile Leu Thr Ala 
            20                  25                  30          


Trp Phe Ile Asn Met Asn Pro Thr Val Glu Tyr Met Asn Ser Ile Tyr 
        35                  40                  45              


Asn Pro Val Pro Trp Glu Lys Glu Glu Tyr Leu Lys Pro Val Leu Glu 
    50                  55                  60                  


Asp Asp Leu Leu Leu Gln Phe Asp Val Glu Asp Leu Tyr Glu Pro Val 
65                  70                  75                  80  


Ser Val Pro Phe Ser Tyr Pro Asn Gly Leu Ser Glu Asn Thr Ser Val 
                85                  90                  95      


Val Glu Lys Leu Lys His Met Glu Ala Arg Ala Leu Ser Ala Glu Ala 
            100                 105                 110         


Ala Leu Ala Arg Ala Arg Glu Asp Leu Gln Lys Met Lys Gln Phe Ala 
        115                 120                 125             


Gln Asp Phe Val Met His Thr Asp Val Arg Thr Cys Ser Ser Ser Thr 
    130                 135                 140                 


Ser Val Ile Ala Asp Leu Gln Glu Asp Glu Asp Gly Val Tyr Phe Ser 
145                 150                 155                 160 


Ser Tyr Gly His Tyr Gly Ile His Glu Glu Met Leu Lys Asp Lys Ile 
                165                 170                 175     


Arg Thr Glu Ser Tyr Arg Asp Phe Ile Tyr Gln Asn Pro His Ile Phe 
            180                 185                 190         


Lys Asp Lys Val Val Leu Asp Val Gly Cys Gly Thr Gly Ile Leu Ser 
        195                 200                 205             


Met Phe Ala Ala Lys Ala Gly Ala Lys Lys Val Leu Gly Val Asp Gln 
    210                 215                 220                 


Ser Glu Ile Leu Tyr Gln Ala Met Asp Ile Ile Arg Leu Asn Lys Leu 
225                 230                 235                 240 


Glu Asp Thr Ile Thr Leu Ile Lys Gly Lys Ile Glu Glu Val His Leu 
                245                 250                 255     


Pro Val Glu Lys Val Asp Val Ile Ile Ser Glu Trp Met Gly Tyr Phe 
            260                 265                 270         


Leu Leu Phe Glu Ser Met Leu Asp Ser Val Leu Tyr Ala Lys Asn Lys 
        275                 280                 285             


Tyr Leu Ala Lys Gly Gly Ser Val Tyr Pro Asp Ile Cys Thr Ile Ser 
    290                 295                 300                 


Leu Val Ala Val Ser Asp Val Asn Lys His Ala Asp Arg Ile Ala Phe 
305                 310                 315                 320 


Trp Asp Asp Val Tyr Gly Phe Lys Met Ser Cys Met Lys Lys Ala Val 
                325                 330                 335     


Ile Pro Glu Ala Val Val Glu Val Leu Asp Pro Lys Thr Leu Ile Ser 
            340                 345                 350         


Glu Pro Cys Gly Ile Lys His Ile Asp Cys His Thr Thr Ser Ile Ser 
        355                 360                 365             


Asp Leu Glu Phe Ser Ser Asp Phe Thr Leu Lys Ile Thr Arg Thr Ser 
    370                 375                 380                 


Met Cys Thr Ala Ile Ala Gly Tyr Phe Asp Ile Tyr Phe Glu Lys Asn 
385                 390                 395                 400 


Cys His Asn Arg Val Val Phe Ser Thr Gly Pro Gln Ser Thr Lys Thr 
                405                 410                 415     


His Trp Lys Gln Thr Val Phe Leu Leu Glu Lys Pro Phe Ser Val Lys 
            420                 425                 430         


Ala Gly Glu Ala Leu Lys Gly Lys Val Thr Val His Lys Ser Lys Lys 
        435                 440                 445             


Asp Pro Arg Ser Leu Thr Val Thr Leu Thr Leu Asn Asn Ser Thr Gln 
    450                 455                 460                 


Thr Tyr Gly Leu Gln 
465                 


<210> 7762
<211> 174
<212> PRT
<213> Homo sapiens

<400> 7762
Met Ala Ser Ala Gly Thr Gln His Tyr Ser Ile Gly Leu Arg Gln Lys 
1               5                   10                  15      


Asn Ser Phe Lys Gln Ser Gly Pro Ser Gly Thr Val Pro Ala Thr Pro 
            20                  25                  30          


Pro Glu Lys Pro Ser Glu Gly Arg Val Trp Pro Gln Ala His Gln Gln 
        35                  40                  45              


Val Lys Pro Ile Trp Lys Leu Glu Lys Lys Gln Val Glu Thr Leu Ser 
    50                  55                  60                  


Ala Gly Leu Gly Pro Gly Leu Leu Gly Val Pro Pro Gln Pro Ala Tyr 
65                  70                  75                  80  


Phe Phe Cys Pro Ser Thr Leu Cys Ser Ser Gly Thr Thr Ala Val Ile 
                85                  90                  95      


Ala Gly His Ser Ser Ser Cys Tyr Leu His Ser Leu Pro Asp Leu Phe 
            100                 105                 110         


Asn Ser Thr Leu Leu Tyr Arg Arg Ser Ser Tyr Arg Gln Lys Pro Tyr 
        115                 120                 125             


Gln Gln Leu Glu Ser Phe Cys Leu Arg Ser Ser Pro Ser Glu Lys Ser 
    130                 135                 140                 


Pro Phe Ser Leu Pro Gln Lys Ser Leu Pro Val Ser Leu Thr Ala Asn 
145                 150                 155                 160 


Lys Ala Thr Ser Ser Met Val Phe Ser Met Ala Gln Pro Met 
                165                 170                 


<210> 7763
<211> 523
<212> PRT
<213> Homo sapiens

<400> 7763
Met Gln Lys Glu Arg Glu Leu Gln Glu Thr Ile Tyr Phe Lys Asn Thr 
1               5                   10                  15      


Trp Pro Ala Cys Met Phe Leu Ile Val Ala Pro Leu Ser Val Leu Tyr 
            20                  25                  30          


Asn Trp Lys Asp Glu Leu Asp Thr Trp Gly Tyr Phe Arg Val Thr Val 
        35                  40                  45              


Leu His Gly Asn Arg Lys Asp Asn Glu Leu Ile Arg Val Lys Gln Arg 
    50                  55                  60                  


Lys Cys Glu Ile Ala Leu Thr Thr Tyr Glu Thr Leu Arg Leu Cys Leu 
65                  70                  75                  80  


Asp Glu Leu Asn Ser Leu Glu Trp Ser Ala Val Ile Val Asp Glu Ala 
                85                  90                  95      


His Arg Ile Lys Asn Pro Lys Ala Arg Val Thr Glu Val Met Lys Ala 
            100                 105                 110         


Leu Lys Cys Asn Val Arg Ile Gly Leu Thr Gly Thr Ile Leu Gln Asn 
        115                 120                 125             


Asn Met Lys Glu Leu Trp Cys Val Met Asp Trp Ala Val Pro Gly Leu 
    130                 135                 140                 


Leu Gly Ser Gly Thr Tyr Phe Lys Lys Gln Phe Ser Asp Pro Val Glu 
145                 150                 155                 160 


His Gly Gln Arg His Thr Ala Thr Lys Arg Glu Leu Ala Thr Gly Arg 
                165                 170                 175     


Lys Ala Met Gln Arg Leu Ala Lys Lys Met Ser Gly Trp Phe Leu Arg 
            180                 185                 190         


Arg Thr Lys Thr Leu Ile Lys Asp Gln Leu Pro Lys Lys Glu Asp Arg 
        195                 200                 205             


Met Val Tyr Cys Ser Leu Thr Asp Phe Gln Lys Ala Val Tyr Gln Thr 
    210                 215                 220                 


Val Leu Glu Thr Glu Asp Val Thr Leu Ile Leu Gln Ser Ser Glu Pro 
225                 230                 235                 240 


Cys Thr Cys Arg Ser Gly Gln Lys Arg Arg Asn Cys Cys Tyr Lys Thr 
                245                 250                 255     


Asn Ser His Gly Glu Thr Val Lys Thr Leu Tyr Leu Ser Tyr Leu Thr 
            260                 265                 270         


Val Leu Gln Lys Val Ala Asn His Val Ala Leu Leu Gln Ala Ala Ser 
        275                 280                 285             


Thr Ser Lys Gln Gln Glu Thr Leu Ile Lys Arg Ile Cys Asp Gln Val 
    290                 295                 300                 


Phe Ser Arg Phe Pro Asp Phe Val Gln Lys Ser Lys Asp Ala Ala Phe 
305                 310                 315                 320 


Glu Thr Leu Ser Asp Pro Lys Tyr Ser Gly Lys Met Lys Val Leu Gln 
                325                 330                 335     


Gln Leu Leu Asn His Cys Arg Lys Asn Arg Asp Lys Val Leu Leu Phe 
            340                 345                 350         


Ser Phe Ser Thr Lys Leu Leu Asp Val Leu Gln Gln Tyr Cys Met Ala 
        355                 360                 365             


Ser Gly Leu Asp Tyr Arg Arg Leu Asp Gly Ser Thr Lys Ser Glu Glu 
    370                 375                 380                 


Arg Leu Lys Ile Val Lys Glu Phe Asn Ser Thr Gln Asp Val Asn Ile 
385                 390                 395                 400 


Cys Leu Val Ser Thr Met Ala Gly Gly Leu Gly Leu Asn Phe Val Gly 
                405                 410                 415     


Ala Asn Val Val Val Leu Phe Asp Pro Thr Trp Asn Pro Ala Asn Asp 
            420                 425                 430         


Leu Gln Ala Ile Asp Arg Ala Tyr Arg Ile Gly Gln Cys Arg Asp Val 
        435                 440                 445             


Lys Val Leu Arg Leu Ile Ser Leu Gly Thr Val Glu Glu Ile Met Tyr 
    450                 455                 460                 


Leu Arg Gln Ile Tyr Lys Gln Gln Leu His Cys Val Val Val Gly Ser 
465                 470                 475                 480 


Glu Asn Ala Lys Arg Tyr Phe Glu Ala Val Gln Gly Ser Lys Glu His 
                485                 490                 495     


Gln Gly Glu Leu Phe Gly Ile His Asn Leu Phe Lys Phe Arg Ser Gln 
            500                 505                 510         


Gly Ser Cys Leu Thr Lys Asp Ile Leu Glu Val 
        515                 520             


<210> 7764
<211> 392
<212> PRT
<213> Homo sapiens

<400> 7764
Met Gly Thr Thr Cys Leu His Leu Gly Thr Leu Glu Gln Ser Leu Val 
1               5                   10                  15      


Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn 
            20                  25                  30          


Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser 
        35                  40                  45              


Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp 
    50                  55                  60                  


Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu 
65                  70                  75                  80  


Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu 
                85                  90                  95      


Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln 
            100                 105                 110         


Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala 
        115                 120                 125             


Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro 
    130                 135                 140                 


Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg 
145                 150                 155                 160 


Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys 
                165                 170                 175     


Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly 
            180                 185                 190         


Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile 
        195                 200                 205             


Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala 
    210                 215                 220                 


Met Ile Thr Arg Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr 
225                 230                 235                 240 


Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val 
                245                 250                 255     


Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe 
            260                 265                 270         


Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu 
        275                 280                 285             


Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser 
    290                 295                 300                 


Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro 
305                 310                 315                 320 


Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu 
                325                 330                 335     


Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn 
            340                 345                 350         


Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val 
        355                 360                 365             


Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val 
    370                 375                 380                 


Leu Arg Lys Leu Leu Thr Leu Asp 
385                 390         


<210> 7765
<211> 521
<212> PRT
<213> Homo sapiens

<400> 7765
Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly Ser Glu 
1               5                   10                  15      


Lys Ala Val Val Gly Thr Thr Tyr Lys His Leu Lys Asp Leu Leu Ser 
            20                  25                  30          


Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro Lys Asn 
        35                  40                  45              


Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile Gln Ser 
    50                  55                  60                  


Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu Ser Glu 
65                  70                  75                  80  


Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu Phe Leu 
                85                  90                  95      


Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln Gly Glu 
            100                 105                 110         


Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu Pro Lys 
        115                 120                 125             


Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys Gln Glu 
    130                 135                 140                 


Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val Ser Lys 
145                 150                 155                 160 


Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys Leu Arg 
                165                 170                 175     


Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys Ser Lys 
            180                 185                 190         


Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys Ala Gly 
        195                 200                 205             


Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu Trp Pro 
    210                 215                 220                 


Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro Lys Ser 
225                 230                 235                 240 


Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser Trp Thr 
                245                 250                 255     


Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr Pro Lys 
            260                 265                 270         


Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr Ser Gln 
        275                 280                 285             


Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser Leu Ile 
    290                 295                 300                 


Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro Lys Asp 
305                 310                 315                 320 


Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Thr Leu Pro 
                325                 330                 335     


Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met Thr Gln 
            340                 345                 350         


Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp Phe Asp 
        355                 360                 365             


Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala Thr Pro 
    370                 375                 380                 


Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln Ser Asp 
385                 390                 395                 400 


Phe Leu Gln Glu Pro Leu Gln Ala Ala Ile Pro Pro Gly Lys Gln Pro 
                405                 410                 415     


Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala Lys Gly Ser Glu Gln 
            420                 425                 430         


Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser Val Thr Ile Asn Thr 
        435                 440                 445             


Ala Pro Phe Gln Ala Met Gln Thr Val Phe Asn Val Asn Ala Pro Leu 
    450                 455                 460                 


Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro Tyr Ser Pro Gly 
465                 470                 475                 480 


Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln Thr Pro Pro Gln Cys 
                485                 490                 495     


Gln Leu Pro Ser Ile His Val Glu Gln Thr Val His Ser Gln Glu Thr 
            500                 505                 510         


Ala Pro Gly Asn His His Ser Thr Phe 
        515                 520     


<210> 7766
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7766
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Glu Lys Ile Leu Asn His Leu Ser Thr 
65                  70                  75                  80  


Leu Arg Arg Asp Arg Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu 
                85                  90                  95      


Ala Asp Ile Leu Ala Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr 
            100                 105                 110         


Ile Val Ala Glu Phe Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu 
        115                 120                 125             


Glu His Leu Leu Glu Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu 
    130                 135                 140                 


Gly Arg Glu Lys Phe Lys Ser Arg Gly Val Gly Glu Leu Ala Arg 
145                 150                 155                 


<210> 7767
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7767
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 7768
<211> 451
<212> PRT
<213> Homo sapiens

<400> 7768
Met Ala Glu Gly Ala Gln Pro His Gln Pro Pro Gln Leu Gly Pro Gly 
1               5                   10                  15      


Ala Ala Ala Arg Gly Met Lys Arg Glu Ser Glu Leu Glu Leu Pro Val 
            20                  25                  30          


Pro Gly Ala Gly Gly Asp Gly Ala Asp Pro Gly Leu Ser Lys Arg Pro 
        35                  40                  45              


Arg Thr Glu Glu Ala Ala Ala Asp Gly Gly Gly Gly Met Gln Asn Glu 
    50                  55                  60                  


Pro Leu Thr Pro Gly Tyr His Gly Phe Pro Ala Arg Asp Ser Gln Gly 
65                  70                  75                  80  


Asn Gln Glu Pro Thr Thr Thr Pro Asp Ala Met Val Gln Pro Phe Thr 
                85                  90                  95      


Thr Ile Pro Phe Pro Pro Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr 
            100                 105                 110         


Gly Val Pro His Thr Gln Asp Tyr Ala Gly Gln Thr Gly Glu His Asn 
        115                 120                 125             


Leu Thr Leu Tyr Gly Ser Thr Gln Ala His Gly Glu Gln Ser Ser Asn 
    130                 135                 140                 


Ser Pro Ser Thr Gln Asn Gly Ser Leu Thr Gln Thr Glu Gly Gly Ala 
145                 150                 155                 160 


Gln Thr Asp Gly Gln Gln Ser Gln Thr Gln Ser Ser Glu Asn Ser Glu 
                165                 170                 175     


Ser Lys Ser Thr Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg 
            180                 185                 190         


Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile 
        195                 200                 205             


Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly 
    210                 215                 220                 


Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys 
225                 230                 235                 240 


Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala 
                245                 250                 255     


Thr Ala Arg Val Met Thr Asn Lys Lys Met Val Thr Pro Tyr Ala Asn 
            260                 265                 270         


Gly Trp Lys Leu Ser Pro Val Val Gly Ala Val Tyr Gly Pro Glu Leu 
        275                 280                 285             


Tyr Ala Ala Ser Ser Phe Gln Ala Asp Val Ser Leu Gly Asn Asp Ala 
    290                 295                 300                 


Ala Val Pro Leu Ser Gly Arg Gly Gly Ile Asn Thr Tyr Ile Pro Leu 
305                 310                 315                 320 


Ile Ser Leu Pro Leu Val Pro Gly Phe Pro Tyr Pro Thr Ala Ala Thr 
                325                 330                 335     


Thr Ala Ala Ala Phe Arg Gly Ala His Leu Arg Gly Arg Gly Arg Thr 
            340                 345                 350         


Val Tyr Gly Ala Val Arg Ala Val Pro Pro Thr Ala Ile Pro Ala Tyr 
        355                 360                 365             


Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr Gly Ala Asp Leu Tyr Gly 
    370                 375                 380                 


Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln Pro Ala Thr Ala Thr Ala Ala 
385                 390                 395                 400 


Thr Ala Ala Ala Ala Ala Ala Ala Ala Tyr Ser Asp Gly Tyr Gly Arg 
                405                 410                 415     


Val Tyr Thr Ala Asp Pro Tyr His Ala Leu Ala Pro Ala Ala Ser Tyr 
            420                 425                 430         


Gly Val Gly Ala Val Ala Ser Leu Tyr Arg Gly Gly Tyr Ser Arg Phe 
        435                 440                 445             


Ala Pro Tyr 
    450     


<210> 7769
<211> 284
<212> PRT
<213> Homo sapiens

<400> 7769
Met Phe Ser Arg Arg Ser His Gly Asp Val Lys Lys Ser Thr Gln Lys 
1               5                   10                  15      


Val Leu Asp Pro Lys Lys Asp Val Leu Thr Arg Leu Lys His Leu Arg 
            20                  25                  30          


Ala Leu Leu Asp Asn Val Asp Ala Asn Asp Leu Lys Gln Phe Phe Glu 
        35                  40                  45              


Thr Asn Tyr Ser Gln Ile Tyr Phe Ile Phe Tyr Glu Asn Phe Ile Ala 
    50                  55                  60                  


Leu Glu Asn Ser Leu Lys Leu Lys Gly Asn Asn Lys Ser Gln Arg Glu 
65                  70                  75                  80  


Glu Leu Asp Ser Ile Leu Phe Leu Phe Glu Lys Ile Leu Gln Phe Leu 
                85                  90                  95      


Pro Glu Arg Ile Phe Phe Arg Trp His Tyr Gln Ser Ile Gly Ser Thr 
            100                 105                 110         


Leu Lys Lys Leu Leu His Thr Gly Asn Ser Ile Lys Ile Arg Cys Glu 
        115                 120                 125             


Gly Ile Arg Leu Phe Leu Leu Trp Leu Gln Ala Leu Gln Thr Asn Cys 
    130                 135                 140                 


Ala Glu Glu Gln Val Leu Ile Phe Ala Cys Leu Val Pro Gly Phe Pro 
145                 150                 155                 160 


Ala Val Met Ser Ser Arg Gly Pro Cys Thr Leu Glu Thr Leu Ile Asn 
                165                 170                 175     


Pro Ser Pro Ser Val Ala Asp Val Lys Ile Tyr Pro Glu Glu Ile Thr 
            180                 185                 190         


Pro Leu Leu Pro Ala Ile Ser Gly Glu Lys Ile Ala Glu Asp Gln Thr 
        195                 200                 205             


Cys Phe Phe Leu Gln Ile Leu Leu Lys Tyr Met Val Ile Gln Ala Ala 
    210                 215                 220                 


Ser Leu Glu Trp Lys Asn Lys Glu Asn Gln Asp Thr Gly Phe Lys Phe 
225                 230                 235                 240 


Leu Phe Thr Leu Phe Arg Lys Tyr Tyr Leu Pro His Leu Phe Pro Ser 
                245                 250                 255     


Phe Thr Lys Leu Thr Asn Ile Tyr Lys Pro Val Leu Asp Ile Pro His 
            260                 265                 270         


Leu Arg Pro Lys Pro Val Tyr Ile Thr Thr Thr Arg 
        275                 280                 


<210> 7770
<211> 281
<212> PRT
<213> Homo sapiens

<400> 7770
Met Gly Asp Thr Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu 
1               5                   10                  15      


Pro Thr Ser Gly Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
            20                  25                  30          


Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
        35                  40                  45              


Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
    50                  55                  60                  


Gly Val Ala Val Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly 
65                  70                  75                  80  


Asp Gly Val Asp Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln 
                85                  90                  95      


Ile Arg Glu Glu Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr 
            100                 105                 110         


Ala Lys Gly Ala Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
        115                 120                 125             


Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
    130                 135                 140                 


Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
145                 150                 155                 160 


Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                165                 170                 175     


Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
            180                 185                 190         


Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
        195                 200                 205             


Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
    210                 215                 220                 


Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
225                 230                 235                 240 


Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser 
                245                 250                 255     


Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
            260                 265                 270         


Gln Arg Ser Lys Ser Asp Ala Thr Ala 
        275                 280     


<210> 7771
<211> 196
<212> PRT
<213> Homo sapiens

<400> 7771
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala 
    130                 135                 140                 


Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr 
145                 150                 155                 160 


Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp 
                165                 170                 175     


Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys 
            180                 185                 190         


Lys Thr Val Cys 
        195     


<210> 7772
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7772
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7773
<211> 361
<212> PRT
<213> Homo sapiens

<400> 7773
Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn Asn Ser Ile Ser 
1               5                   10                  15      


Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg Phe Thr Asn Ala 
            20                  25                  30          


Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly Lys Asp Val Ser 
        35                  40                  45              


Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser Ser Ala His Ser 
    50                  55                  60                  


Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg Asn Pro Gly Thr 
65                  70                  75                  80  


Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Ala Gly Tyr Lys Arg Ala 
                85                  90                  95      


Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys Glu Lys Lys Arg Lys 
            100                 105                 110         


Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg Pro Lys Gly Asn Lys 
        115                 120                 125             


Asn Gln Glu Asn Val Ser His Leu Ser Val Ser Ser Ala Ser Pro Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr Ser Ser Ser Leu Gln 
145                 150                 155                 160 


Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu Gln Ser Leu Ser Val 
                165                 170                 175     


Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met Gln Tyr Arg His Asp 
            180                 185                 190         


Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu Leu Asn Ala Ile His 
        195                 200                 205             


Asn Asp Arg Gly Asp Ser Ser Thr Leu Thr Lys Gln Glu Leu Lys Phe 
    210                 215                 220                 


Ile Gly Ile Tyr Asn Ser Asn Asp Val Ala Val Ser Phe Pro Asn Val 
225                 230                 235                 240 


Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser Ser Ser His Leu Pro 
                245                 250                 255     


Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly Ala Leu Ser Pro Ser 
            260                 265                 270         


Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr Thr Gln Ala Asn Thr 
        275                 280                 285             


Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser His Met Tyr Gly Asn 
    290                 295                 300                 


Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala Gln Ser Glu Asn Asn 
305                 310                 315                 320 


Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg Asn Leu Val Gly Arg 
                325                 330                 335     


Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg Ser Pro Val Ser Ser 
            340                 345                 350         


Leu Gln Ile Arg Tyr Asp Gln Pro Gly 
        355                 360     


<210> 7774
<211> 141
<212> PRT
<213> Homo sapiens

<400> 7774
Met Ala Ala Ala Pro Pro Ser Tyr Cys Phe Val Ala Phe Pro Pro Arg 
1               5                   10                  15      


Ala Lys Asp Gly Leu Val Val Phe Gly Lys Asn Ser Ala Arg Pro Arg 
            20                  25                  30          


Asp Glu Val Gln Glu Val Val Tyr Phe Ser Ala Ala Asp His Glu Pro 
        35                  40                  45              


Glu Ser Lys Val Glu Cys Thr Tyr Ile Ser Ile Asp Gln Val Pro Arg 
    50                  55                  60                  


Thr Tyr Ala Ile Met Ile Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Ala Asn Glu Ala Ile Asn 
                85                  90                  95      


Thr Arg Glu Pro Ala Ala Glu Ile Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Gly Glu Thr Ala Lys Glu Ala Leu Asp 
        115                 120                 125             


Val Ile Val Ser Leu Leu Glu Glu His Gly Gln Gly Gly 
    130                 135                 140     


<210> 7775
<211> 190
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7775
Xaa Gln Leu Ala Ala Leu Lys Glu Ile Gln Ala Glu Val Gln Glu Lys 
1               5                   10                  15      


Glu Ser Asp Ala Val Lys Pro Lys Asn Gln Asp Ile Gln Gly Gly Lys 
            20                  25                  30          


Ala Ala Pro Ala Glu Ala Leu Gly Ile Pro Asp Glu His Tyr Leu Asp 
        35                  40                  45              


Asn Leu Cys Ile Phe Cys Gly Glu Arg Ser Glu Ser Phe Thr Glu Glu 
    50                  55                  60                  


Gly Leu Asp Leu His Tyr Trp Lys His Cys Leu Met Leu Thr Arg Cys 
65                  70                  75                  80  


Asp His Cys Lys Gln Val Val Glu Ile Ser Ser Leu Thr Glu His Leu 
                85                  90                  95      


Leu Thr Glu Cys Asp Lys Lys Asp Gly Phe Gly Lys Cys Tyr Arg Cys 
            100                 105                 110         


Ser Glu Ala Val Phe Lys Glu Glu Leu Pro Arg His Ile Lys His Lys 
        115                 120                 125             


Asp Cys Asn Pro Ala Lys Pro Glu Lys Leu Ala Asn Arg Cys Pro Leu 
    130                 135                 140                 


Cys His Glu Asn Phe Ser Pro Gly Glu Glu Ala Trp Lys Ala His Leu 
145                 150                 155                 160 


Met Gly Pro Ala Gly Cys Thr Met Asn Leu Arg Lys Thr His Ile Leu 
                165                 170                 175     


Gln Lys Ala Pro Ala Leu Gln Pro Gly Glu Gly Gln Arg Arg 
            180                 185                 190 


<210> 7776
<211> 240
<212> PRT
<213> Homo sapiens

<400> 7776
Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
1               5                   10                  15      


Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
            20                  25                  30          


Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
        35                  40                  45              


Arg Lys Ile Lys Pro Lys Asn Ser Lys Gln Ala Glu Arg Glu Glu Lys 
    50                  55                  60                  


Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
65                  70                  75                  80  


Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                85                  90                  95      


Leu Ala Gly Ala Ala Gly Gly Pro Gly Ile Gly Arg Ala Ala Gly Arg 
            100                 105                 110         


Gly Ile Pro Ala Gly Val Pro Met Pro Gln Ala Pro Ala Gly Leu Ala 
        115                 120                 125             


Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
    130                 135                 140                 


Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser 
145                 150                 155                 160 


Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Gly Pro Pro 
                165                 170                 175     


Pro Pro Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly Pro Pro 
            180                 185                 190         


Pro Gly Met Arg Pro Pro Met Gly Pro Pro Met Gly Ile Pro Pro Gly 
        195                 200                 205             


Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
    210                 215                 220                 


Pro Gly Met Arg Gly Pro Pro Pro Pro Gly Met Arg Pro Pro Arg Pro 
225                 230                 235                 240 


<210> 7777
<211> 139
<212> PRT
<213> Homo sapiens

<400> 7777
Met Glu Thr Asp Cys Asn Pro Met Glu Leu Ser Ser Met Ser Gly Phe 
1               5                   10                  15      


Glu Glu Gly Ser Glu Leu Asn Gly Phe Glu Gly Thr Asp Met Lys Asp 
            20                  25                  30          


Met Arg Leu Glu Ala Glu Ala Val Val Asn Asp Val Leu Phe Ala Val 
        35                  40                  45              


Asn Asn Met Phe Val Ser Lys Ser Leu Arg Cys Ala Asp Asp Val Ala 
    50                  55                  60                  


Tyr Ile Asn Val Glu Thr Lys Glu Arg Asn Arg Tyr Cys Leu Glu Leu 
65                  70                  75                  80  


Thr Glu Ala Gly Leu Lys Val Val Gly Tyr Ala Phe Asp Gln Val Asp 
                85                  90                  95      


Asp His Leu Gln Thr Pro Tyr His Glu Thr Val Tyr Ser Leu Leu Asp 
            100                 105                 110         


Thr Leu Ser Pro Ala Tyr Arg Glu Ala Phe Gly Asn Ala Leu Leu Gln 
        115                 120                 125             


Arg Leu Glu Ala Leu Lys Arg Asp Gly Gln Ser 
    130                 135                 


<210> 7778
<211> 201
<212> PRT
<213> Homo sapiens

<400> 7778
Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Phe Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Glu Tyr 
                85                  90                  95      


Gly Ser Gln Gln Val Ala Asp Leu Thr Leu Asn Leu Asp Asp Tyr Ile 
            100                 105                 110         


Asp Ala Glu His Leu Gly Asp Phe His Arg Cys Asp Pro Leu Gly Pro 
        115                 120                 125             


Phe Val Val Gly Gly Glu Asp Leu Asp Pro Phe Gly Pro Arg Arg Gly 
    130                 135                 140                 


Gly Met Ile Val Asp Pro Leu Arg Ser Gly Phe Pro Arg Ala Leu Ile 
145                 150                 155                 160 


Asp Pro Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro Gly Ala Val Pro 
                165                 170                 175     


Pro Gly Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly Thr Ser Pro Pro 
            180                 185                 190         


Gly Pro Arg Pro Asp Arg Arg Gly Gln 
        195                 200     


<210> 7779
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7779
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 7780
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7780
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 7781
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7781
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7782
<211> 362
<212> PRT
<213> Homo sapiens

<400> 7782
Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Cys Thr Asn Gly His Leu Met Cys Ala Gly Cys Phe Ile His 
                85                  90                  95      


Leu Leu Ala Asp Ala Arg Leu Lys Glu Glu Gln Ala Thr Cys Pro Asn 
            100                 105                 110         


Cys Arg Cys Glu Ile Ser Lys Ser Leu Cys Cys Arg Asn Leu Ala Val 
        115                 120                 125             


Glu Lys Ala Val Ser Glu Leu Pro Ser Glu Cys Gly Phe Cys Leu Arg 
    130                 135                 140                 


Gln Phe Pro Arg Ser Leu Leu Glu Arg His Gln Lys Glu Glu Cys Gln 
145                 150                 155                 160 


Asp Arg Val Thr Gln Cys Lys Tyr Lys Arg Ile Gly Cys Pro Trp His 
                165                 170                 175     


Gly Pro Phe His Glu Leu Thr Val His Glu Ala Ala Cys Ala His Pro 
            180                 185                 190         


Thr Lys Thr Gly Ser Glu Leu Met Glu Ile Leu Asp Gly Met Asp Gln 
        195                 200                 205             


Ser His Arg Lys Glu Met Gln Leu Tyr Asn Ser Ile Phe Ser Leu Leu 
    210                 215                 220                 


Ser Phe Glu Lys Ile Gly Tyr Thr Glu Val Gln Phe Arg Pro Tyr Arg 
225                 230                 235                 240 


Thr Asp Asp Phe Ile Thr Arg Leu Tyr Tyr Glu Thr Pro Arg Phe Thr 
                245                 250                 255     


Val Leu Asn Gln Thr Trp Val Leu Lys Ala Arg Val Asn Asp Ser Glu 
            260                 265                 270         


Arg Asn Pro Asn Leu Ser Cys Lys Arg Thr Leu Ser Phe Gln Leu Leu 
        275                 280                 285             


Leu Lys Ser Lys Val Thr Ala Pro Leu Glu Cys Ser Phe Leu Leu Leu 
    290                 295                 300                 


Lys Gly Pro Tyr Asp Asp Val Arg Ile Ser Pro Val Ile Tyr His Phe 
305                 310                 315                 320 


Val Phe Thr Asn Glu Ser Asn Glu Thr Asp Tyr Val Pro Leu Pro Ile 
                325                 330                 335     


Ile Asp Ser Val Glu Cys Asn Lys Leu Leu Ala Ala Lys Asn Ile Asn 
            340                 345                 350         


Leu Arg Leu Phe Leu Phe Gln Ile Gln Lys 
        355                 360         


<210> 7783
<211> 90
<212> PRT
<213> Homo sapiens

<400> 7783
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly 
                85                  90  


<210> 7784
<211> 833
<212> PRT
<213> Homo sapiens

<400> 7784
Met Ala Val Glu Asp Ser Thr Leu Gln Val Val Val Arg Val Arg Pro 
1               5                   10                  15      


Pro Thr Pro Arg Glu Leu Asp Ser Gln Arg Arg Pro Val Val Gln Val 
            20                  25                  30          


Val Asp Glu Arg Val Leu Val Phe Asn Pro Glu Glu Pro Asp Gly Gly 
        35                  40                  45              


Phe Pro Gly Leu Lys Trp Gly Gly Thr His Asp Gly Pro Lys Lys Lys 
    50                  55                  60                  


Gly Lys Asp Leu Thr Phe Val Phe Asp Arg Val Phe Gly Glu Ala Ala 
65                  70                  75                  80  


Thr Gln Gln Asp Val Phe Gln His Thr Thr His Ser Val Leu Asp Ser 
                85                  90                  95      


Phe Leu Gln Gly Tyr Asn Cys Ser Val Phe Ala Tyr Gly Ala Thr Gly 
            100                 105                 110         


Ala Gly Lys Thr His Thr Met Leu Gly Arg Glu Gly Asp Pro Gly Ile 
        115                 120                 125             


Met Tyr Leu Thr Thr Val Glu Leu Tyr Arg Arg Leu Glu Ala Arg Gln 
    130                 135                 140                 


Gln Glu Lys His Phe Glu Val Leu Ile Ser Tyr Gln Glu Val Tyr Asn 
145                 150                 155                 160 


Glu Gln Ile His Asp Leu Leu Glu Pro Lys Gly Pro Leu Ala Ile Arg 
                165                 170                 175     


Glu Asp Pro Asp Lys Gly Val Val Val Gln Gly Leu Ser Phe His Gln 
            180                 185                 190         


Pro Ala Ser Ala Glu Gln Leu Leu Glu Ile Leu Thr Arg Gly Asn Arg 
        195                 200                 205             


Asn Arg Thr Gln His Pro Thr Asp Ala Asn Ala Thr Ser Ser Arg Ser 
    210                 215                 220                 


His Ala Ile Phe Gln Ile Phe Val Lys Gln Gln Asp Arg Val Pro Gly 
225                 230                 235                 240 


Leu Thr Gln Ala Val Gln Val Ala Lys Met Ser Leu Ile Asp Leu Ala 
                245                 250                 255     


Gly Ser Glu Arg Ala Ser Ser Thr His Ala Lys Gly Glu Arg Leu Arg 
            260                 265                 270         


Glu Gly Ala Asn Ile Asn Arg Ser Leu Leu Ala Leu Ile Asn Val Leu 
        275                 280                 285             


Asn Ala Leu Ala Asp Ala Lys Gly Arg Lys Thr His Val Pro Tyr Arg 
    290                 295                 300                 


Asp Ser Lys Leu Thr Arg Leu Leu Lys Asp Ser Leu Gly Gly Asn Cys 
305                 310                 315                 320 


Arg Thr Val Met Ile Ala Ala Ile Ser Pro Ser Ser Leu Thr Tyr Glu 
                325                 330                 335     


Asp Thr Tyr Asn Thr Leu Lys Tyr Ala Asp Arg Ala Lys Glu Ile Arg 
            340                 345                 350         


Leu Ser Leu Lys Ser Asn Val Thr Ser Leu Asp Cys His Ile Ser Gln 
        355                 360                 365             


Tyr Ala Thr Ile Cys Gln Gln Leu Gln Ala Glu Val Ala Ala Leu Arg 
    370                 375                 380                 


Lys Lys Leu Gln Val Tyr Glu Gly Gly Gly Gln Pro Pro Pro Gln Asp 
385                 390                 395                 400 


Leu Pro Gly Ser Pro Lys Ser Gly Pro Pro Pro Glu His Leu Pro Ser 
                405                 410                 415     


Ser Pro Leu Pro Pro His Pro Pro Ser Gln Pro Cys Thr Pro Glu Leu 
            420                 425                 430         


Pro Ala Gly Pro Arg Ala Leu Gln Glu Glu Ser Leu Gly Met Glu Ala 
        435                 440                 445             


Gln Val Glu Arg Ala Met Glu Gly Asn Ser Ser Asp Gln Glu Gln Ser 
    450                 455                 460                 


Pro Glu Asp Glu Asp Glu Gly Pro Ala Glu Glu Val Pro Thr Gln Met 
465                 470                 475                 480 


Pro Glu Gln Asn Pro Thr His Ala Leu Pro Glu Ser Pro Arg Leu Thr 
                485                 490                 495     


Leu Gln Pro Lys Pro Val Val Gly His Phe Ser Ala Arg Glu Leu Asp 
            500                 505                 510         


Gly Asp Arg Ser Lys Gln Leu Ala Leu Lys Val Leu Cys Val Ala Gln 
        515                 520                 525             


Arg Gln Tyr Ser Leu Leu Gln Ala Ala Asn Leu Leu Thr Pro Asp Met 
    530                 535                 540                 


Ile Thr Glu Phe Glu Thr Leu Gln Gln Leu Val Gln Glu Glu Lys Ile 
545                 550                 555                 560 


Glu Pro Gly Ala Glu Ala Leu Arg Thr Ser Gly Leu Ala Arg Gly Ala 
                565                 570                 575     


Pro Leu Ala Gln Glu Leu Cys Ser Glu Ser Ile Pro Val Pro Ser Pro 
            580                 585                 590         


Leu Cys Pro Glu Pro Pro Gly Tyr Thr Gly Pro Val Thr Arg Thr Met 
        595                 600                 605             


Ala Arg Arg Leu Ser Gly Pro Leu His Thr Leu Gly Ile Pro Pro Gly 
    610                 615                 620                 


Pro Asn Cys Thr Pro Ala Gln Gly Ser Arg Trp Pro Met Glu Lys Lys 
625                 630                 635                 640 


Arg Arg Arg Pro Ser Ala Leu Glu Ala Asp Ser Pro Met Ala Pro Lys 
                645                 650                 655     


Arg Gly Thr Lys Arg Gln Arg Gln Ser Phe Leu Pro Cys Leu Arg Arg 
            660                 665                 670         


Gly Ser Leu Pro Asp Thr Gln Pro Ser Gln Gly Pro Ser Thr Pro Lys 
        675                 680                 685             


Gly Glu Arg Ala Ser Ser Pro Cys His Ser Pro Arg Val Cys Pro Ala 
    690                 695                 700                 


Thr Val Ile Lys Ser Arg Val Pro Leu Gly Pro Ser Ala Met Gln Asn 
705                 710                 715                 720 


Cys Ser Thr Pro Leu Ala Leu Pro Thr Arg Asp Leu Asn Ala Thr Phe 
                725                 730                 735     


Asp Leu Ser Glu Glu Pro Pro Ser Lys Pro Ser Phe His Glu Cys Ile 
            740                 745                 750         


Gly Trp Asp Lys Ile Pro Gln Glu Leu Ser Arg Leu Asp Gln Pro Phe 
        755                 760                 765             


Ile Pro Arg Ala Pro Val Pro Leu Phe Thr Met Lys Gly Pro Lys Pro 
    770                 775                 780                 


Thr Ser Ser Leu Pro Gly Thr Ser Ala Cys Lys Lys Lys Arg Val Ala 
785                 790                 795                 800 


Ser Ser Ser Val Ser His Gly Arg Ser Arg Ile Ala Arg Leu Pro Ser 
                805                 810                 815     


Ser Thr Leu Lys Arg Pro Ala Gly Pro Leu Val Leu Pro Gly Asp Trp 
            820                 825                 830         


His 
    


<210> 7785
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7785
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 7786
<211> 217
<212> PRT
<213> Homo sapiens

<400> 7786
Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Phe Gln Arg Pro Gln 
1               5                   10                  15      


Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg 
            20                  25                  30          


Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile 
        35                  40                  45              


Met Met Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro 
    50                  55                  60                  


Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly 
65                  70                  75                  80  


Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr 
                85                  90                  95      


Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe 
            100                 105                 110         


Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr 
        115                 120                 125             


Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile 
    130                 135                 140                 


Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser 
                165                 170                 175     


Thr Pro Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser 
            180                 185                 190         


Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr 
        195                 200                 205             


Pro Val Thr Ala Ala Ser Asp Gln Lys 
    210                 215         


<210> 7787
<211> 322
<212> PRT
<213> Homo sapiens

<400> 7787
Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Arg Leu Arg Gly Cys Ser Ser Gln Thr 
    290                 295                 300                 


His Phe Cys Trp Asn Ile Cys Gln Leu Cys Asp Asn Ser Ser Val Lys 
305                 310                 315                 320 


Leu Glu 
        


<210> 7788
<211> 580
<212> PRT
<213> Homo sapiens

<400> 7788
Met Arg Ala Leu Thr Val Gln Arg Val Lys Phe Ala Met Asp Leu Pro 
1               5                   10                  15      


Leu Leu Lys Arg Ala Gly Gln Asp Leu Ala Glu Lys Thr Lys Asn Phe 
            20                  25                  30          


Val Ser Arg Ser Leu Val Ile Gly Glu Val Leu Ser Met Ala Asp Met 
        35                  40                  45              


Ala Thr Gly Val Lys Cys Gly Ile Ile Tyr Trp Leu Phe Gly Gly Ala 
    50                  55                  60                  


Ile Arg Asn Leu Gly Ser Pro Glu His Val Thr Lys Trp Phe Gln Pro 
65                  70                  75                  80  


Leu Gln Glu Gln Lys Tyr Thr Gly Met Phe Ala Met Thr Glu Arg Gly 
                85                  90                  95      


His Gly Ser Asn Ala Arg Gly Ile Gln Thr Glu Ala Thr Phe Asp Leu 
            100                 105                 110         


Ser Ala Gln Glu Phe Val Ile Asp Thr Pro Cys Glu Asn Ala Glu Lys 
        115                 120                 125             


Met Tyr Ile Gly Asn Ala Met Tyr Gly Asn Tyr Ala Ala Val Phe Ala 
    130                 135                 140                 


Gln Leu Ile Ile Asp Gly Arg Ser Gln Gly Pro His Cys Phe Ile Val 
145                 150                 155                 160 


Pro Val Arg Asp Glu Asn Gly Ser Leu Tyr Pro Gly Val Thr Ala Ile 
                165                 170                 175     


Asp Met Met Tyr Lys Glu Gly Leu His Gly Val Asp Asn Gly Ile Leu 
            180                 185                 190         


Ile Phe Asp Lys Val Arg Ile Pro Arg Glu Asn Leu Leu Asp Lys Phe 
        195                 200                 205             


Gly Ser Val Ala Pro Asp Gly Gln Tyr His Ser Pro Ile Arg Asn Lys 
    210                 215                 220                 


Ser Ala Arg Phe Asn Ala Met Leu Ala Ala Leu Thr Pro Ser Arg Leu 
225                 230                 235                 240 


Ala Val Ala Phe Gln Ala Met Gly Ala Met Lys Leu Gly Leu Thr Ile 
                245                 250                 255     


Ala Ile Arg Tyr Ser His Ser Arg Arg Gln Phe Gly Pro Lys Thr Lys 
            260                 265                 270         


Glu Glu Val Lys Ile Ile Glu His Gln Thr Gln Thr Leu Arg Leu Met 
        275                 280                 285             


Pro His Leu Ala Thr Ala Leu Ala Leu Thr Phe Val Ser Arg Tyr Ala 
    290                 295                 300                 


Gly Ala Leu Leu Asp Glu Asp Val Phe Gln Gly Lys Glu Leu Val Asn 
305                 310                 315                 320 


Ser Arg Ser Leu Gln Ala Leu Val Ala Gly Leu Lys Ala Tyr Ser Thr 
                325                 330                 335     


Trp Glu Asn Ile Arg Cys Leu Gln Asp Cys Arg Glu Cys Thr Gly Gly 
            340                 345                 350         


Met Val Val Gly Arg Glu Leu Leu Ala Gln Tyr Thr Lys Gln Tyr Glu 
        355                 360                 365             


Glu Lys Pro Leu Phe Gly Leu Leu Gln Asn Trp Ala Glu Ser Val Gly 
    370                 375                 380                 


Asp Lys Leu Arg Thr Ser Phe Leu Ala Phe Asn Met Asp Thr Val Asp 
385                 390                 395                 400 


Asp Leu Ala Phe Leu Leu Lys Ala Val Lys Phe Arg Glu Arg Val Leu 
                405                 410                 415     


Gln Arg Gly Leu Val Ala Arg Ile Tyr Tyr Lys Val Lys Thr Lys Lys 
            420                 425                 430         


Glu Asp Phe Phe His Ala Trp Asn Ser Cys Leu His His Val Ala Ser 
        435                 440                 445             


Leu Ser Leu Ala His Thr His Arg Val Thr Leu Glu Gln Phe Ser Leu 
    450                 455                 460                 


Ala Val Lys Ser Cys Pro Asp Gln Glu Asp Gln Thr Leu Leu Met Lys 
465                 470                 475                 480 


Phe Cys Leu Leu Tyr Gly Thr Lys Leu Val Phe Gln Glu Arg Ala Trp 
                485                 490                 495     


Tyr Leu Glu His Lys Tyr Leu Thr Pro Met Ala Ser Thr Arg Ile Arg 
            500                 505                 510         


Asn Gln Leu Leu Asp Leu Cys Asp Ser Val Lys Asp Asp Ala Arg Arg 
        515                 520                 525             


Val Ile Ser Thr Phe Asn Ile Pro His Thr Tyr Leu His Ala Pro Ile 
    530                 535                 540                 


Ala Gly Ile Ser Asn Pro Arg Ala Ala Trp Ala Phe Tyr Pro Ala Pro 
545                 550                 555                 560 


Leu Gln Pro Arg Pro Arg Glu Glu Ala Arg Ser Arg Arg Pro Lys Leu 
                565                 570                 575     


Gly Ala Lys Leu 
            580 


<210> 7789
<211> 186
<212> PRT
<213> Homo sapiens

<400> 7789
Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Cys Val Tyr Phe Arg Asp Arg 
    130                 135                 140                 


Ser Ala Ala Thr Thr Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln 
145                 150                 155                 160 


Pro Thr Asn Glu Ser Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val 
                165                 170                 175     


Glu Glu Gly Glu Lys Glu Phe His Val Arg 
            180                 185     


<210> 7790
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7790
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7791
<211> 870
<212> PRT
<213> Homo sapiens

<400> 7791
Met Ser Arg Asn Pro Ser Ser Asn Ser Pro Glu Glu Asp Thr Val Pro 
1               5                   10                  15      


Val Pro Lys Gly Ser Val Pro Ala Ala Arg Pro Ser Arg Gly Gly Met 
            20                  25                  30          


Ser Val Val Gly Ile Asp Leu Gly Phe Leu Asn Cys Tyr Ile Ala Val 
        35                  40                  45              


Ala Arg Ser Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp Arg 
    50                  55                  60                  


Cys Thr Pro Ala Cys Ile Ser Leu Gly Ser Arg Thr Arg Ala Ile Gly 
65                  70                  75                  80  


Asn Ala Ala Lys Ser Gln Ile Val Thr Asn Val Arg Asn Thr Ile His 
                85                  90                  95      


Gly Phe Lys Lys Leu His Gly Arg Ser Phe Asp Asp Pro Ile Val Gln 
            100                 105                 110         


Thr Glu Arg Ile Arg Leu Pro Tyr Glu Leu Gln Lys Met Pro Asn Gly 
        115                 120                 125             


Ser Ala Gly Val Lys Val Arg Tyr Leu Glu Glu Glu Arg Pro Phe Ala 
    130                 135                 140                 


Ile Glu Gln Val Thr Gly Met Leu Leu Ala Lys Leu Lys Glu Thr Ser 
145                 150                 155                 160 


Glu Asn Ala Leu Lys Lys Pro Val Ala Asp Cys Val Ile Ser Ile Pro 
                165                 170                 175     


Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Met Ala Ala Ala Gln 
            180                 185                 190         


Val Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala Val 
        195                 200                 205             


Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Pro Leu Asp Glu 
    210                 215                 220                 


Lys Pro Arg Asn Val Val Phe Ile Asp Met Gly His Ser Ala Tyr Gln 
225                 230                 235                 240 


Val Leu Val Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Ala Thr 
                245                 250                 255     


Thr Phe Asp Pro Tyr Leu Gly Gly Arg Asn Phe Asp Glu Ala Leu Val 
            260                 265                 270         


Asp Tyr Phe Cys Asp Glu Phe Lys Thr Lys Tyr Lys Ile Asn Val Lys 
        275                 280                 285             


Glu Asn Ser Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys Leu 
    290                 295                 300                 


Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Asn Ile Glu 
305                 310                 315                 320 


Cys Phe Met Asn Asp Leu Asp Val Ser Ser Lys Met Asn Arg Ala Gln 
                325                 330                 335     


Phe Glu Gln Leu Cys Ala Ser Leu Leu Ala Arg Val Glu Pro Pro Leu 
            340                 345                 350         


Lys Ala Val Met Glu Gln Ala Asn Leu Gln Arg Glu Asp Ile Ser Ser 
        355                 360                 365             


Ile Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu Gln 
    370                 375                 380                 


Ile Thr Lys Phe Phe Leu Lys Asp Ile Ser Thr Thr Leu Asn Ala Asp 
385                 390                 395                 400 


Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser Pro 
                405                 410                 415     


Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Leu Val Pro Tyr Ser 
            420                 425                 430         


Ile Thr Leu Arg Trp Lys Thr Ser Phe Glu Asp Gly Ser Gly Glu Cys 
        435                 440                 445             


Glu Val Phe Cys Lys Asn His Pro Ala Pro Phe Ser Lys Val Ile Thr 
    450                 455                 460                 


Phe His Lys Lys Glu Pro Phe Glu Leu Glu Ala Phe Tyr Thr Asn Leu 
465                 470                 475                 480 


His Glu Val Pro Tyr Pro Asp Ala Arg Ile Gly Ser Phe Thr Ile Gln 
                485                 490                 495     


Asn Val Phe Pro Gln Ser Asp Gly Asp Ser Ser Lys Val Lys Val Lys 
            500                 505                 510         


Val Arg Val Asn Ile His Gly Ile Phe Ser Val Ala Ser Ala Ser Val 
        515                 520                 525             


Ile Glu Lys Gln Asn Leu Glu Gly Asp His Ser Asp Ala Pro Met Glu 
    530                 535                 540                 


Thr Glu Thr Ser Phe Lys Asn Glu Asn Lys Asp Asn Met Asp Lys Met 
545                 550                 555                 560 


Gln Val Asp Gln Glu Glu Gly His Gln Lys Cys His Ala Glu His Thr 
                565                 570                 575     


Pro Glu Glu Glu Ile Asp His Thr Gly Ala Lys Thr Lys Ser Ala Val 
            580                 585                 590         


Ser Asp Lys Gln Asp Arg Leu Asn Gln Thr Leu Lys Lys Gly Lys Val 
        595                 600                 605             


Lys Ser Ile Asp Leu Pro Ile Gln Ser Ser Leu Cys Arg Gln Leu Gly 
    610                 615                 620                 


Gln Asp Leu Leu Asn Ser Tyr Ile Glu Asn Glu Gly Lys Met Ile Met 
625                 630                 635                 640 


Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu 
                645                 650                 655     


Glu Tyr Val Tyr Asp Phe Arg Asp Arg Leu Gly Thr Val Tyr Glu Lys 
            660                 665                 670         


Phe Ile Thr Pro Glu Asp Leu Ser Lys Leu Ser Ala Val Leu Glu Asp 
        675                 680                 685             


Thr Glu Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val 
    690                 695                 700                 


Tyr Val Asp Lys Leu Gln Glu Leu Lys Lys Tyr Gly Gln Pro Ile Gln 
705                 710                 715                 720 


Met Lys Tyr Met Glu His Glu Glu Arg Pro Lys Ala Leu Asn Asp Leu 
                725                 730                 735     


Gly Lys Lys Ile Gln Leu Val Met Lys Val Ile Glu Ala Tyr Arg Asn 
            740                 745                 750         


Lys Asp Glu Arg Tyr Asp His Leu Asp Pro Thr Glu Met Glu Lys Val 
        755                 760                 765             


Glu Lys Cys Ile Ser Asp Ala Met Ser Trp Leu Asn Ser Lys Met Asn 
    770                 775                 780                 


Ala Gln Asn Lys Leu Ser Leu Thr Gln Asp Pro Val Val Lys Val Ser 
785                 790                 795                 800 


Glu Ile Val Ala Lys Ser Lys Glu Leu Asp Asn Phe Cys Asn Pro Ile 
                805                 810                 815     


Ile Tyr Lys Pro Lys Pro Lys Ala Glu Val Pro Glu Asp Lys Pro Lys 
            820                 825                 830         


Ala Asn Ser Glu His Asn Gly Pro Met Asp Gly Gln Ser Gly Thr Glu 
        835                 840                 845             


Thr Lys Ser Asp Ser Thr Lys Asp Ser Ser Gln His Thr Lys Ser Ser 
    850                 855                 860                 


Gly Glu Met Glu Val Asp 
865                 870 


<210> 7792
<211> 1820
<212> PRT
<213> Homo sapiens

<400> 7792
Met Glu Pro Pro Gln Glu Thr Asn Arg Pro Phe Ser Thr Leu Asp Asn 
1               5                   10                  15      


Arg Ser Gly Gln Val Gln Val Leu Ser Ala Thr Pro Leu Leu Gln Arg 
            20                  25                  30          


Asn Pro Tyr Ser Ser Pro Asp Ile Met His Ile Lys Gly Ser Glu Ala 
        35                  40                  45              


Ser Ser Val Pro Tyr Ala Leu Asn Gln Gly Thr Thr Ala Leu Pro Lys 
    50                  55                  60                  


Asn Lys Asn Gln Glu Gly Thr Gly His Arg Leu Leu Asn Met Leu Arg 
65                  70                  75                  80  


Lys Thr Leu Lys Glu Ser Asp Ser Glu Glu Leu Glu Ile Thr Gln Glu 
                85                  90                  95      


Thr Pro Asn Leu Val Pro Phe Gly Asp Val Val Gly Cys Leu Gly Ile 
            100                 105                 110         


His Ile Lys Asn Cys Arg His Phe Met Pro Lys Ile Ser Leu Gln His 
        115                 120                 125             


Tyr Ala Asn Leu Phe Ile Arg Ile Ser Ile Asn Lys Ala Val Lys Cys 
    130                 135                 140                 


Thr Lys Met Cys Ser Leu Leu Ser Lys Asn Asp Glu Lys Asn Thr Val 
145                 150                 155                 160 


Ile Lys Phe Asp Glu Val Lys Tyr Phe Ser Val Gln Val Pro Arg Arg 
                165                 170                 175     


Tyr Asp Asp Lys Arg Asn Asn Ile Leu Leu Glu Leu Ile Gln Tyr Asp 
            180                 185                 190         


Asn Arg Glu Lys Arg Ala Phe Leu Leu Gly Ser Val Gln Ile His Leu 
        195                 200                 205             


Tyr Glu Val Ile Gln Lys Gly Cys Phe Ile Glu Glu Val Gln Val Leu 
    210                 215                 220                 


His Gly Asn Ile Phe Val Cys Arg Leu Glu Val Glu Phe Met Phe Ser 
225                 230                 235                 240 


Tyr Gly Asn Phe Gly Tyr Gly Phe Ser His Gln Leu Lys Pro Leu Gln 
                245                 250                 255     


Lys Ile Thr Glu Pro Ser Met Phe Met Asn Leu Ala Pro Pro Pro Glu 
            260                 265                 270         


Arg Thr Asp Pro Val Thr Lys Val Ile Thr Pro Gln Thr Val Glu Tyr 
        275                 280                 285             


Pro Ala Phe Leu Ser Pro Asp Leu Asn Val Thr Val Gly Thr Pro Ala 
    290                 295                 300                 


Val Gln Ser Ser Asn Gln Pro Ser Val Val Arg Leu Glu Lys Leu Gln 
305                 310                 315                 320 


Gln Gln Pro Arg Glu Arg Leu Glu Lys Met Lys Lys Glu Tyr Arg Asn 
                325                 330                 335     


Leu Asn Thr Trp Ile Asp Lys Ala Asn Tyr Leu Glu Ser Ile Leu Met 
            340                 345                 350         


Pro Lys Leu Glu His Lys Asp Ser Glu Glu Thr Asn Ile Asp Glu Ala 
        355                 360                 365             


Ser Glu Asn Thr Lys Ser Asn His Pro Glu Glu Glu Leu Glu Asn Ile 
    370                 375                 380                 


Val Gly Val Asp Ile Pro Leu Val Asn Glu Glu Ala Glu Thr Thr Ala 
385                 390                 395                 400 


Asn Glu Leu Leu Asp Asn Asp Ser Glu Lys Gly Leu Thr Ile Pro Thr 
                405                 410                 415     


Leu Asn Gln Ser Asp Gln Asp Asn Ser Thr Ala Asp Ala Ser Lys Asn 
            420                 425                 430         


Asp Glu Ser Thr Pro Ser Pro Thr Glu Val His Ser Leu Cys Thr Ile 
        435                 440                 445             


Ser Asn Gln Glu Thr Ile Lys Ala Gly Arg Ile Pro Pro Leu Gly Glu 
    450                 455                 460                 


Arg Gln Ser Glu Ser Met Pro Asp Arg Lys Met Lys Asn Val Phe Phe 
465                 470                 475                 480 


Pro Leu Glu Val Lys Leu Lys Asp Asn Tyr Pro Ser Ile Leu Lys Ala 
                485                 490                 495     


Asp Ser Ser Leu Ser Glu Val Ala Phe Ser Pro Lys Glu Tyr Asn Ser 
            500                 505                 510         


Pro Ser Phe Arg Pro Glu Tyr Ile Glu Phe Lys Pro Lys Phe Gln Phe 
        515                 520                 525             


Gln Lys Phe Asn Lys Asn Gly Phe Asp Pro Phe Leu Arg Asn Ile Asn 
    530                 535                 540                 


Lys Met Ser Val Arg Lys Arg Lys Asp Gln Asp Ile Tyr Lys Tyr Arg 
545                 550                 555                 560 


Asn Ile Leu Gly Ala Glu Val Ile Glu His Glu Asp Gln Asp Pro Pro 
                565                 570                 575     


Tyr Pro Ala Gln Ser Lys Thr Ala Gly Pro Ala Asn Thr Thr Trp Ala 
            580                 585                 590         


His Asp Pro Asn Ile Phe Thr Thr Lys Met Leu Glu Thr Glu Asn Lys 
        595                 600                 605             


Leu Ala Pro Asp Pro Thr Ile Asn Thr Ile Lys Gly Leu Asp Thr Lys 
    610                 615                 620                 


Asn Ser Leu Lys Glu Asn Leu Pro Asn Val Ser Leu Pro Ser Ile Lys 
625                 630                 635                 640 


Gly Glu Ser Ser Arg Ala Gly Asn Val Gln Ala Asn Thr Cys His Leu 
                645                 650                 655     


Ser Lys Ser Leu Asn Phe Thr Pro His Ile Glu Tyr Leu Lys Gln Ser 
            660                 665                 670         


Met Ile Leu Lys Ser Ile Leu Ser Glu Asn Leu Gln Asp Leu Ser Asp 
        675                 680                 685             


Lys Leu Phe Ser Lys Pro Glu Val Ser Met Asn Ser Glu Ala Arg Glu 
    690                 695                 700                 


Lys Ser Ser Ser Pro Leu Leu Ser Ile His Asp Lys Ser Ser Ser Ser 
705                 710                 715                 720 


Met Glu Asp Asn Val Leu Glu Lys Lys Gln Asp Leu Asn Asn Trp Leu 
                725                 730                 735     


Ser Glu Lys Asp Ile Leu Asn Ser Lys Thr Thr Leu Ser Gln Ile Ile 
            740                 745                 750         


Lys Asn Ile Pro Ala Asp Ser Phe Ser Glu Gly Ser Gln Ile Ile Glu 
        755                 760                 765             


Asn Ile Pro Ala Asp Ser Leu Leu Glu Gly Gly Gln Val Ile Lys Asn 
    770                 775                 780                 


Ile Pro Glu Tyr Ser Leu Ser Glu Gly Gly Gln Ile Ile Lys Asn Ile 
785                 790                 795                 800 


Pro Ala Asp Ser Phe Leu Glu Ser Gly Pro Gly Gln Ser Pro Glu Val 
                805                 810                 815     


Glu Glu His Val Ser Lys Lys His Phe Glu Ala Asp Glu Arg Asp Phe 
            820                 825                 830         


Pro Ile Lys Lys Asn Ser Ser Thr Lys Lys Lys His Leu Ile Ser Glu 
        835                 840                 845             


Val Pro Asn Ser Lys Ser Gly Ser Ser Gly Thr Val His Asp Tyr Ile 
    850                 855                 860                 


Met Arg Gln Ile Phe Thr Ala Pro Ile Phe Ser Glu Leu Glu Ile Glu 
865                 870                 875                 880 


Val Lys Glu Pro Ser Glu Thr Pro Met Asn Leu Glu Asn Gln Leu Pro 
                885                 890                 895     


Thr Pro Trp Lys Arg Ser Leu Ser Ser His Ile Leu Phe His Glu Glu 
            900                 905                 910         


Asn Ala Asp Glu Ile Glu Leu Pro Gln Pro Arg Ser Ala Thr Ser Gln 
        915                 920                 925             


Ile Ile Gln Ala Phe Pro Ile Asp Thr Leu Leu Glu Ser Gly Ile Ile 
    930                 935                 940                 


Lys Val Ile Glu Leu Asp Lys Glu His His Lys Ser Ser Leu Leu Gly 
945                 950                 955                 960 


Thr Gly Ile Thr Ser Pro Lys Gly Asn Leu Lys Asp Ser Gln Glu Tyr 
                965                 970                 975     


Tyr Ser Glu Ile Arg Ser Glu Thr Glu Pro Leu Ser Glu Gln Ser Ile 
            980                 985                 990         


Pro Ile Ile Pro Lys Asp Thr Thr  Ser Val Ser Arg Ala  Glu Phe Ile 
        995                 1000                 1005             


Gln Glu  Asp Gln Asn Met Phe  Pro Gln Asp Ser Ser  Tyr Tyr Ser 
    1010                 1015                 1020             


Ile Ala  Asn Lys Glu Leu Tyr  Leu Pro Arg Asn Gly  Gln Arg Leu 
    1025                 1030                 1035             


Cys Lys  Asp Lys Asn Asp Leu  Ser Ser Thr Leu Glu  Ser Leu Thr 
    1040                 1045                 1050             


Asn Ser  Leu Met Asp Lys Leu  Ser Glu Ser Asp Glu  Ile Met Leu 
    1055                 1060                 1065             


Lys Ser  Phe Leu Lys Asn Ile  Phe Asn Val Phe Phe  Lys Tyr Asn 
    1070                 1075                 1080             


His Ser  Glu Arg Arg Gly Gln  Pro Glu Lys Glu Leu  Glu Arg Leu 
    1085                 1090                 1095             


Ile Gln  Pro Ser Phe Thr Ser  Asp Thr Glu His Leu  Glu Glu Leu 
    1100                 1105                 1110             


Gln Glu  Asp Phe Asp Lys Ala  Asp Lys Leu Asp Arg  Lys Pro Ile 
    1115                 1120                 1125             


Leu Ser  Pro Lys Leu Arg Val  Phe Leu Glu Glu Leu  Ser Glu Ser 
    1130                 1135                 1140             


Glu Val  Lys His Leu Lys Ser  Glu Leu Ser Lys Gln  Ile Gln His 
    1145                 1150                 1155             


Tyr Leu  Val Glu Arg Leu Ser  Glu Ser Gly His Ile  Thr Lys Glu 
    1160                 1165                 1170             


Asp Leu  Pro Lys Ile Tyr Gln  Asn Leu Tyr Leu Met  Asn Glu Lys 
    1175                 1180                 1185             


Ala Glu  Gln Lys Gly Pro Asn  Ser Phe Gln Gly Lys  Tyr Ser Glu 
    1190                 1195                 1200             


Thr Val  Lys Glu Ile Met Ser  Phe Val Asn Asn Phe  Asn His His 
    1205                 1210                 1215             


Phe Ile  Asp Lys His Leu Glu  Ile Lys Leu Arg Ser  Phe Leu Lys 
    1220                 1225                 1230             


Glu Ile  Leu Gln Asn Tyr Phe  Leu Lys Asn Ile Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Phe  Asn Glu Thr Ala Ser  Glu Thr Ile Tyr Pro  Asn Ile Ser 
    1250                 1255                 1260             


Ser Leu  Arg Thr Lys Ser Val  Ser Ile Ser Phe His  Glu Leu Glu 
    1265                 1270                 1275             


Gln Asp  Ile Ser Lys Gly Ser  Phe Gly Arg Arg Phe  Glu Ile Asn 
    1280                 1285                 1290             


Met Lys  Tyr Pro Leu Ser Lys  Ser Leu Gln Asn Tyr  Leu Ile Ala 
    1295                 1300                 1305             


Leu Ser  Glu Asn Glu Leu Leu  His Leu Lys Ala Asp  Leu Ser Lys 
    1310                 1315                 1320             


His Leu  Gln Ser Leu Phe Ile  Glu Lys Leu Ser Lys  Ser Gly Leu 
    1325                 1330                 1335             


Met Thr  Lys Lys Gln Leu Glu  Gly Ile Asn Gln His  Ile Asn Leu 
    1340                 1345                 1350             


Leu Asn  Ser Ser Ser Ile Pro  Leu Lys Tyr Ile Lys  Thr His Leu 
    1355                 1360                 1365             


Pro Phe  Arg Asp Asp Cys His  Phe Val Glu Lys His  Ser Glu Lys 
    1370                 1375                 1380             


Gln Asn  Lys Tyr Ser Arg Ile  Val Gln Gln Thr Thr  Leu Gln Thr 
    1385                 1390                 1395             


Val Ser  Glu Asp Lys Leu Arg  Glu Ala Glu Leu Ile  Arg Glu Lys 
    1400                 1405                 1410             


Glu Lys  Lys Tyr Phe Pro Leu  Gln Asn Leu Lys Gly  Asn Ser Ser 
    1415                 1420                 1425             


Leu Ile  Lys Glu Gln Lys Ser  Tyr Tyr Thr Lys Glu  Glu Ala Lys 
    1430                 1435                 1440             


Thr Pro  Ser Leu Ile Lys Val  Gln Pro Ser Ser Asn  Glu Asn Ile 
    1445                 1450                 1455             


Gln Ala  Ser Pro Leu Ser Lys  Ser Ser Glu Ile Leu  Thr Asp Ile 
    1460                 1465                 1470             


Leu Leu  Lys Lys Leu Arg Lys  Glu His Val Phe Thr  Gln Leu Pro 
    1475                 1480                 1485             


Gln Ala  Glu Asn Ser Val His  Lys Thr Glu Ile Gln  Asp Pro Tyr 
    1490                 1495                 1500             


Ser Trp  Gly Gly Lys Ser Lys  Ile Thr Gln Ser Lys  Ala Trp Cys 
    1505                 1510                 1515             


Glu Lys  Thr Leu Lys Met Lys  Ser Leu Asp Arg Lys  Glu His Val 
    1520                 1525                 1530             


Asn Ile  Tyr Lys Trp Thr Val  Gln Glu Lys Pro Glu  Ala Val Leu 
    1535                 1540                 1545             


Thr Ser  Tyr Pro Arg Ile Pro  Asn Ala Arg Met Pro  Arg Glu Asp 
    1550                 1555                 1560             


Glu Tyr  Leu Asn Arg Ile Thr  Phe Pro Ser Trp Gln  Ser Ser Thr 
    1565                 1570                 1575             


Leu Thr  His Phe Asn Thr Glu  Thr Gly Glu Lys Ser  Lys Leu Glu 
    1580                 1585                 1590             


Asp Gln  Tyr Cys Gln Thr Leu  Lys Gly Asn Asn Asn  Asn Asn Lys 
    1595                 1600                 1605             


Lys His  Leu Val Thr Phe Ala  Gln Tyr Lys Lys Glu  Ile Gln Thr 
    1610                 1615                 1620             


Leu Tyr  Ile Lys Pro Asp Glu  Ile Cys Ser Glu Lys  Cys Ala Lys 
    1625                 1630                 1635             


Phe Pro  Glu Ile Gln Ser Phe  Gln Tyr Lys Val Val  Glu Asp Glu 
    1640                 1645                 1650             


Lys Asn  Leu Lys Pro His Leu  Phe Pro Glu Leu Phe  Lys Ile Glu 
    1655                 1660                 1665             


Asp Leu  Lys Pro Lys Val Arg  Lys Glu Arg Asp Arg  Val Ala Gln 
    1670                 1675                 1680             


Pro Lys  Lys Ser Phe Asn Lys  Ile Val Arg Ile Leu  Pro Thr Thr 
    1685                 1690                 1695             


Leu Pro  Thr Thr Arg Ile His  Leu Lys Lys Ser Val  Pro Arg Thr 
    1700                 1705                 1710             


Leu Leu  His Trp Thr Ala Arg  Arg Thr Ile His Asp  Cys Ser Asp 
    1715                 1720                 1725             


Lys Phe  Glu Asp Leu His Asp  Met Thr Ser Phe Thr  His Leu Lys 
    1730                 1735                 1740             


Lys Val  Lys Ser Arg Ser Arg  Leu Leu Gly Lys Ser  Ser Asp Asp 
    1745                 1750                 1755             


Ile His  Asn His Ala Arg His  Ser Ala Arg Pro Tyr  Thr Ala Pro 
    1760                 1765                 1770             


Glu Val  Asn Lys Gln Arg Glu  Ser Tyr Ser Gly Lys  Phe Thr Ser 
    1775                 1780                 1785             


Arg Arg  Met Val Ser Ser Gly  Leu Val His Ile Asn  Asp Lys Thr 
    1790                 1795                 1800             


Ser Asp  Tyr Glu Met His Lys  Met Arg Pro Lys Lys  Ile Lys Arg 
    1805                 1810                 1815             


Gly Tyr  
    1820 


<210> 7793
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7793
Met Glu Pro Thr Arg Asp Cys Pro Leu Phe Gly Gly Ala Phe Ser Ala 
1               5                   10                  15      


Ile Leu Pro Met Gly Ala Ile Asp Val Ser Asp Leu Arg Pro Val Pro 
            20                  25                  30          


Asp Asn Gln Glu Val Phe Cys His Pro Val Thr Asp Gln Ser Leu Ile 
        35                  40                  45              


Val Glu Leu Leu Glu Leu Gln Ala His Val Arg Gly Glu Ala Ala Ala 
    50                  55                  60                  


Arg Tyr His Phe Glu Asp Val Gly Gly Val Gln Gly Ala Arg Ala Val 
65                  70                  75                  80  


His Val Glu Ser Val Gln Pro Leu Ser Leu Glu Asn Leu Ala Leu Arg 
                85                  90                  95      


Gly Arg Cys Gln Glu Ala Trp Val Leu Ser Gly Lys Gln Gln Ile Ala 
            100                 105                 110         


Lys Glu Asn Gln Gln Val Arg Ala Arg Glu Cys Val Met Ser Trp Lys 
        115                 120                 125             


Gly Gly Ser Gly Asp Ala Glu Ile Gln Val Ser Ile Leu Thr Leu Ile 
    130                 135                 140                 


Pro Leu Gly Ser Lys Gly Arg Asp Thr Ser Ser Gly Leu Ala Glu Ala 
145                 150                 155                 160 


Ala Pro Val Pro Asp 
                165 


<210> 7794
<211> 1493
<212> PRT
<213> Homo sapiens

<400> 7794
Met Ala Ser Ile Thr Gln Leu Phe Asp Asp Leu Cys Glu Ala Leu Leu 
1               5                   10                  15      


Pro Ala Ala Lys Thr His Leu Gly Gln Arg Ser Val Asn Arg Lys Arg 
            20                  25                  30          


Ala Lys Arg Ser Leu Lys Lys Val Ala Tyr Asn Ala Leu Phe Thr Asn 
        35                  40                  45              


Leu Phe Gln Asp Glu Thr Gln Gln Leu Gln Pro Asp Met Ser Lys Leu 
    50                  55                  60                  


Pro Ala Arg Asn Lys Ile Leu Met Leu Ser Phe Asp Leu Arg Val Gly 
65                  70                  75                  80  


Gly Leu Gly Pro Lys Ala Asp Arg Leu Glu Glu Leu Val Glu Glu Leu 
                85                  90                  95      


Glu Ala Ala Pro Cys Cys Pro Leu Leu Glu Val Gly Ser Val Leu Asp 
            100                 105                 110         


Leu Leu Val Gln Leu Ala Gly Ser Gly Pro Pro Gln Val Leu Pro Arg 
        115                 120                 125             


Lys Arg Asp Tyr Phe Leu Asn Asn Lys His Val Gly Arg Asn Val Pro 
    130                 135                 140                 


Tyr Ser Gly Tyr Asp Cys Asp Asp Leu Ser Val Phe Glu Met Asp Val 
145                 150                 155                 160 


Gln Ser Leu Ile Ser Arg Glu Glu Cys Leu Cys His Ser Met Ile Gln 
                165                 170                 175     


Glu Thr Leu Gln Val Met Glu Ala Ala Pro Gly Thr Gly Leu Pro Thr 
            180                 185                 190         


Val Gly Leu Phe Ser Phe Gly Asp Pro Cys Gly Asp Arg Phe Glu Arg 
        195                 200                 205             


Asp Thr Arg Val Ser Leu Phe Gly Ala Leu Val His Ser Arg Thr Tyr 
    210                 215                 220                 


Asp Met Asp Val Arg Leu Gly Leu Pro Pro Val Pro Asp Asn Ala Asp 
225                 230                 235                 240 


Leu Ser Gly Leu Ala Ile Lys Val Pro Pro Ser Val Asp Gln Trp Glu 
                245                 250                 255     


Asp Glu Gly Phe Gln Ser Ala Ser Asn Leu Thr Pro Asp Ser Gln Ser 
            260                 265                 270         


Glu Pro Ser Val Thr Pro Asp Val Asp Leu Trp Glu Ala Ala Leu Thr 
        275                 280                 285             


Tyr Glu Ala Ser Lys Arg Arg Cys Trp Glu Arg Val Gly Cys Pro Pro 
    290                 295                 300                 


Gly His Arg Glu Glu Pro Tyr Leu Thr Glu Ala Gly Arg Asp Ala Phe 
305                 310                 315                 320 


Asp Lys Phe Cys Arg Leu His Gln Gly Glu Leu Gln Leu Leu Ala Gly 
                325                 330                 335     


Gly Val Leu Gln Ala Pro Gln Pro Val Leu Val Lys Glu Cys Glu Leu 
            340                 345                 350         


Val Lys Asp Val Leu Asn Val Leu Ile Gly Val Val Ser Ala Thr Phe 
        355                 360                 365             


Ser Leu Cys Gln Pro Ala Gln Ala Phe Val Val Lys Arg Gly Val His 
    370                 375                 380                 


Val Ser Gly Ala Ser Pro Glu Ser Ile Ser Ser Leu Leu Ser Glu Val 
385                 390                 395                 400 


Ala Glu Tyr Gly Thr Cys Tyr Thr Arg Leu Ser His Phe Ser Leu Gln 
                405                 410                 415     


Pro Val Leu Asp Ser Leu Tyr Ser Lys Gly Leu Val Phe Gln Ala Phe 
            420                 425                 430         


Thr Ser Gly Leu Arg Arg Tyr Leu Gln Tyr Tyr Arg Ala Cys Val Leu 
        435                 440                 445             


Ser Thr Pro Pro Thr Leu Ser Leu Leu Thr Ile Gly Phe Leu Phe Lys 
    450                 455                 460                 


Lys Leu Gly Arg Gln Leu Arg Tyr Leu Ala Glu Leu Cys Gly Val Gly 
465                 470                 475                 480 


Ala Val Leu Pro Gly Thr Cys Gly Gly Gly Pro Arg Ala Ala Phe Pro 
                485                 490                 495     


Thr Gly Val Lys Leu Leu Ser Tyr Leu Tyr Gln Glu Ala Leu His Asn 
            500                 505                 510         


Cys Ser Asn Glu His Tyr Pro Val Leu Leu Ser Leu Leu Lys Thr Ser 
        515                 520                 525             


Cys Glu Pro Tyr Thr Arg Phe Ile His Asp Trp Val Tyr Ser Gly Val 
    530                 535                 540                 


Phe Arg Asp Ala Tyr Gly Glu Phe Met Ile Gln Val Asn His Glu Tyr 
545                 550                 555                 560 


Leu Ser Phe Arg Asp Lys Leu Tyr Trp Thr His Gly Tyr Val Leu Ile 
                565                 570                 575     


Ser Lys Glu Val Glu Asp Cys Val Pro Val Phe Leu Lys His Ile Ala 
            580                 585                 590         


His Asp Ile Tyr Val Cys Gly Lys Thr Ile Asn Leu Leu Lys Leu Cys 
        595                 600                 605             


Cys Pro Arg His Tyr Leu Cys Trp Ser Asp Val Pro Val Pro Arg Ile 
    610                 615                 620                 


Ser Val Ile Phe Ser Leu Glu Glu Leu Lys Glu Ile Glu Lys Asp Cys 
625                 630                 635                 640 


Ala Val Tyr Val Gly Arg Met Glu Arg Val Ala Arg His Ser Ser Val 
                645                 650                 655     


Ser Lys Glu Glu Lys Glu Leu Arg Met Glu Ile Ala Lys Gln Glu Leu 
            660                 665                 670         


Ile Ala His Ala Arg Glu Ala Ala Ser Arg Val Leu Ser Ala Leu Ser 
        675                 680                 685             


Asp Arg Gln Met Ser Glu Arg Met Ala Leu Asp Ala Arg Lys Arg Glu 
    690                 695                 700                 


Gln Phe Gln Arg Leu Lys Glu Gln Phe Val Lys Asp Gln Glu Arg Arg 
705                 710                 715                 720 


Gln Ala Ala Arg Gln Glu Glu Leu Asp Asp Asp Phe Ser Tyr Ala Arg 
                725                 730                 735     


Glu Leu Arg Asp Arg Glu Arg Arg Leu Lys Ser Leu Glu Glu Glu Leu 
            740                 745                 750         


Glu Arg Lys Ala Arg Gln Ala Leu Val Asp His Tyr Ser Lys Leu Ser 
        755                 760                 765             


Ala Glu Ala Ala Arg Arg Glu Gln Lys Ala Leu Trp Arg Ile Gln Arg 
    770                 775                 780                 


His Arg Leu Glu Ser Ala Arg Leu Arg Phe Leu Leu Glu Asp Glu Lys 
785                 790                 795                 800 


His Ile Gln Glu Met Leu Lys Ala Val Ser Glu Ala His Gln Pro Gln 
                805                 810                 815     


Glu Pro Pro Asp Val Leu Leu Ser Val His Pro Gln Val Thr Ser Pro 
            820                 825                 830         


Gly Pro Glu His Pro Glu Gly Gly Gln Gly Cys Asp Ser Gly Ser Ala 
        835                 840                 845             


Glu Gln His Ser Pro Ala Trp Asp Gly Trp Asn Arg Pro Gly Leu Leu 
    850                 855                 860                 


Thr Pro Gln Pro Leu Lys Pro Leu Ala Val Gly Ala Gly Gly Arg Gly 
865                 870                 875                 880 


Leu Gln Gln Ala Glu Gly Ala Arg Pro Phe Ser Asp Ser Leu Ser Ile 
                885                 890                 895     


Gly Asp Phe Leu Pro Val Gly Pro Gly Ala Glu Pro Ser Val Gln Thr 
            900                 905                 910         


Gly Met Val Pro Leu Leu Glu Val Ala Leu Gln Thr Ile Asn Leu Asp 
        915                 920                 925             


Leu Pro Pro Ser Ala Pro Gly Glu Ala Pro Ala Ala Ala Ser Thr Gln 
    930                 935                 940                 


Pro Ser Arg Pro Gln Glu Tyr Asp Phe Ser Thr Val Leu Arg Pro Ala 
945                 950                 955                 960 


Val Ala Thr Ser Pro Ala Pro Gly Pro Leu Gln Ala Ala Glu Cys Ser 
                965                 970                 975     


Leu Gly Ser Ser Gly Leu Gln Leu Trp Glu Asp Ser Cys Gly Lys Met 
            980                 985                 990         


Asp Ala Cys Gly Ser Ala Ser Arg  Glu Thr Leu Leu Pro  Ser His Pro 
        995                 1000                 1005             


Pro Arg  Arg Ala Ala Leu Glu  Glu Gly Ser Ser Gln  Pro Thr Glu 
    1010                 1015                 1020             


Arg Leu  Phe Gly Gln Val Ser  Gly Gly Gly Leu Pro  Thr Gly Asp 
    1025                 1030                 1035             


Tyr Ala  Ser Glu Ile Ala Pro  Thr Arg Pro Arg Trp  Asn Thr His 
    1040                 1045                 1050             


Gly His  Val Ser Asp Ala Ser  Ile Arg Val Gly Glu  Asn Val Ser 
    1055                 1060                 1065             


Asp Val  Ala Pro Thr Gln Pro  Arg Trp Asn Thr His  Gly His Val 
    1070                 1075                 1080             


Ser Asn  Ala Ser Ile Ser Leu  Gly Glu Ser Val Ser  Asp Val Ala 
    1085                 1090                 1095             


Pro Thr  Arg Pro Arg Trp Asn  Ile His Gly His Val  Ser Asn Ala 
    1100                 1105                 1110             


Ser Ile  Arg Val Gly Glu Asn  Val Ser Asp Val Ala  Pro Thr Arg 
    1115                 1120                 1125             


Pro Arg  Trp Asn Thr His Gly  His Val Ser Asn Ala  Ser Ile Arg 
    1130                 1135                 1140             


Val Gly  Glu Asn Val Ser Asp  Val Ala Pro Thr Arg  Pro Arg Trp 
    1145                 1150                 1155             


Asn Thr  His Gly His Val Ser  Asp Ala Ser Ile Ser  Leu Gly Glu 
    1160                 1165                 1170             


Ser Val  Ser Asp Met Ala Pro  Ala Arg Pro Arg Trp  Asn Thr His 
    1175                 1180                 1185             


Gly His  Val Ser Asp Ala Ser  Ile Ser Leu Gly Glu  Ser Val Ser 
    1190                 1195                 1200             


Asp Met  Ala Pro Thr Arg Pro  Arg Trp Asn Thr His  Gly His Val 
    1205                 1210                 1215             


Ser Asp  Thr Ser Ile Arg Val  Gly Glu Asn Val Ser  Asp Val Ala 
    1220                 1225                 1230             


Pro Ile  Arg Ser Arg Cys Asn  Thr His Gly His Val  Ser Asp Ala 
    1235                 1240                 1245             


Ser Ile  Ser Leu Gly Glu Pro  Val Ser Asp Val Val  Ser Thr Arg 
    1250                 1255                 1260             


Pro Arg  Trp Asn Thr His Val  Pro Ile Pro Pro Pro  His Met Val 
    1265                 1270                 1275             


Leu Gly  Ala Leu Ser Pro Glu  Ala Glu Pro Asn Thr  Pro Arg Pro 
    1280                 1285                 1290             


Gln Gln  Ser Pro Pro Gly His  Thr Ser Gln Ser Ala  Leu Ser Leu 
    1295                 1300                 1305             


Gly Ala  Gln Ser Thr Val Leu  Asp Cys Gly Pro Arg  Leu Pro Val 
    1310                 1315                 1320             


Glu Val  Gly Pro Ser Leu Ser  Ser Pro Ser Ser Gly  Cys Gly Glu 
    1325                 1330                 1335             


Gly Ser  Ile Ser Val Gly Glu  Asn Val Ser Asp Val  Ala Pro Thr 
    1340                 1345                 1350             


Gln Pro  Trp Trp Pro Asn Thr  Pro Gly Asp Ser Val  Ser Glu Glu 
    1355                 1360                 1365             


Leu Gly  Gln Ser Arg Val Ala  Gly Gly Gln Glu Trp  Asp Cys Gly 
    1370                 1375                 1380             


Thr His  Arg Ala Trp Glu Ala  Leu Gly Gly Ala Gly  Thr Leu Arg 
    1385                 1390                 1395             


Thr Ser  Leu Gln Ile Gly Leu  Ser Thr His Arg Lys  Thr Gln Leu 
    1400                 1405                 1410             


Pro Arg  Ala Ala Gln Ala Val  Val Arg Arg Arg Arg  His Arg Arg 
    1415                 1420                 1425             


Arg Arg  Leu Arg Val Gly Ser  Arg Pro Thr Trp Gln  Ala Trp Gln 
    1430                 1435                 1440             


Gly Ser  Thr Thr Trp Ser Gly  Thr Arg Thr Val Thr  Ser Pro Cys 
    1445                 1450                 1455             


Pro Ser  Arg Pro Leu Leu Ile  Phe Cys Ala Pro Cys  Phe Pro Gly 
    1460                 1465                 1470             


Pro Ser  Pro Ser Pro Trp Thr  Pro Arg Ser Ser Leu  Pro Leu Met 
    1475                 1480                 1485             


Arg Leu  Leu Cys Ser 
    1490             


<210> 7795
<211> 358
<212> PRT
<213> Homo sapiens

<400> 7795
Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 
            20                  25                  30          


Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 
        35                  40                  45              


Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 
    50                  55                  60                  


Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 
65                  70                  75                  80  


Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 
                85                  90                  95      


Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 
            100                 105                 110         


Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 
        115                 120                 125             


Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 
    130                 135                 140                 


Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 
                165                 170                 175     


Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 
            180                 185                 190         


Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 
        195                 200                 205             


Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 
    210                 215                 220                 


Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 
225                 230                 235                 240 


Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 
                245                 250                 255     


Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 
            260                 265                 270         


Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 
        275                 280                 285             


Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 
    290                 295                 300                 


Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 
305                 310                 315                 320 


Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 
                325                 330                 335     


Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 
            340                 345                 350         


Asn Gly Leu Gln Gly Tyr 
        355             


<210> 7796
<211> 918
<212> PRT
<213> Homo sapiens

<400> 7796
Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg 
1               5                   10                  15      


Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala 
            20                  25                  30          


Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu 
        35                  40                  45              


Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro 
    50                  55                  60                  


Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln 
65                  70                  75                  80  


Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu 
                85                  90                  95      


Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu 
            100                 105                 110         


Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His 
        115                 120                 125             


Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His 
    130                 135                 140                 


Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly 
                165                 170                 175     


Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro 
            180                 185                 190         


Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp 
        195                 200                 205             


Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala 
    210                 215                 220                 


Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile 
225                 230                 235                 240 


Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu 
                245                 250                 255     


Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly 
            260                 265                 270         


Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu 
        275                 280                 285             


Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile 
    290                 295                 300                 


Gln Asn Met Pro Asn Val Arg Asp His Asp Ala Ser Val Tyr Leu Arg 
305                 310                 315                 320 


Leu Gln Gly Asp Ala Leu Ser Val Gly Gly Tyr Glu Ala Asn Pro Ile 
                325                 330                 335     


Phe Trp Glu Glu Val Ser Asp Lys Phe Ala Phe Gly Leu Phe Asp Leu 
            340                 345                 350         


Asp Trp Glu Val Phe Thr Gln His Ile Glu Gly Ala Ile Asn Arg Val 
        355                 360                 365             


Pro Val Leu Glu Lys Thr Gly Ile Lys Ser Thr Val Cys Gly Pro Glu 
    370                 375                 380                 


Ser Phe Thr Pro Asp His Lys Pro Leu Met Gly Glu Ala Pro Glu Leu 
385                 390                 395                 400 


Arg Gly Phe Phe Leu Gly Cys Gly Phe Asn Ser Ala Gly Met Met Leu 
                405                 410                 415     


Gly Gly Gly Cys Gly Gln Glu Leu Ala His Trp Ile Ile His Gly Arg 
            420                 425                 430         


Pro Glu Lys Asp Met His Gly Tyr Asp Ile Arg Arg Phe His His Ser 
        435                 440                 445             


Leu Thr Asp His Pro Arg Trp Ile Arg Glu Arg Ser His Glu Ser Tyr 
    450                 455                 460                 


Ala Lys Asn Tyr Ser Val Val Phe Pro His Asp Glu Pro Leu Ala Gly 
465                 470                 475                 480 


Arg Asn Met Arg Arg Asp Pro Leu His Glu Glu Leu Leu Gly Gln Gly 
                485                 490                 495     


Cys Val Phe Gln Glu Arg His Gly Trp Glu Arg Pro Gly Trp Phe His 
            500                 505                 510         


Pro Arg Gly Pro Ala Pro Val Leu Glu Tyr Asp Tyr Tyr Gly Ala Tyr 
        515                 520                 525             


Gly Ser Arg Ala His Glu Asp Tyr Ala Tyr Arg Arg Leu Leu Ala Asp 
    530                 535                 540                 


Glu Tyr Thr Phe Ala Phe Pro Pro His His Asp Thr Ile Lys Lys Glu 
545                 550                 555                 560 


Cys Leu Ala Cys Arg Gly Ala Ala Ala Val Phe Asp Met Ser Tyr Phe 
                565                 570                 575     


Gly Lys Phe Tyr Leu Val Gly Leu Asp Ala Arg Lys Ala Ala Asp Trp 
            580                 585                 590         


Leu Phe Ser Ala Asp Val Ser Arg Pro Pro Gly Ser Thr Val Tyr Thr 
        595                 600                 605             


Cys Met Leu Asn His Arg Gly Gly Thr Glu Ser Asp Leu Thr Val Ser 
    610                 615                 620                 


Arg Leu Ala Pro Ser His Gln Ala Ser Pro Leu Ala Pro Ala Phe Glu 
625                 630                 635                 640 


Gly Asp Gly Tyr Tyr Leu Ala Met Gly Gly Ala Val Ala Gln His Asn 
                645                 650                 655     


Trp Ser His Ile Thr Thr Val Leu Gln Asp Gln Lys Ser Gln Cys Gln 
            660                 665                 670         


Leu Ile Asp Ser Ser Glu Asp Leu Gly Met Ile Ser Ile Gln Gly Pro 
        675                 680                 685             


Ala Ser Arg Ala Ile Leu Gln Glu Val Leu Asp Ala Asp Leu Ser Asn 
    690                 695                 700                 


Glu Ala Phe Pro Phe Ser Thr His Lys Leu Leu Arg Ala Ala Gly His 
705                 710                 715                 720 


Leu Val Arg Ala Met Arg Leu Ser Phe Val Gly Glu Leu Gly Trp Glu 
                725                 730                 735     


Leu His Ile Pro Lys Ala Ser Cys Val Pro Val Tyr Arg Ala Val Met 
            740                 745                 750         


Ala Ala Gly Ala Lys His Gly Leu Ile Asn Ala Gly Tyr Arg Ala Ile 
        755                 760                 765             


Asp Ser Leu Ser Ile Glu Lys Gly Tyr Arg His Trp His Ala Asp Leu 
    770                 775                 780                 


Arg Pro Asp Asp Ser Pro Leu Glu Ala Gly Leu Ala Phe Thr Cys Lys 
785                 790                 795                 800 


Leu Lys Ser Pro Val Pro Phe Leu Gly Arg Glu Ala Leu Glu Gln Gln 
                805                 810                 815     


Arg Ala Ala Gly Leu Arg Arg Arg Leu Val Cys Phe Thr Met Glu Asp 
            820                 825                 830         


Lys Val Pro Met Phe Gly Leu Glu Ala Ile Trp Arg Asn Gly Gln Val 
        835                 840                 845             


Val Gly His Val Arg Arg Ala Asp Phe Gly Phe Ala Ile Asp Lys Thr 
    850                 855                 860                 


Ile Ala Tyr Gly Tyr Ile His Asp Pro Ser Gly Gly Pro Val Ser Leu 
865                 870                 875                 880 


Asp Phe Val Lys Ser Gly Asp Tyr Ala Leu Glu Arg Met Gly Val Thr 
                885                 890                 895     


Tyr Gly Ala Gln Ala His Leu Lys Ser Pro Phe Asp Pro Asn Asn Lys 
            900                 905                 910         


Arg Val Lys Gly Ile Tyr 
        915             


<210> 7797
<211> 73
<212> PRT
<213> Homo sapiens

<400> 7797
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Pro Val Cys Arg Leu Pro Lys Arg Pro Glu Pro Cys Pro Pro Leu Lys 
            20                  25                  30          


Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro 
        35                  40                  45              


Gln Gln Cys Gln Gln Lys Tyr Pro Leu Val Thr Pro Ser Pro Pro Cys 
    50                  55                  60                  


Gln Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70              


<210> 7798
<211> 191
<212> PRT
<213> Homo sapiens

<400> 7798
Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Ile Ala Arg Gly Phe Glu Arg Gly Leu Glu Pro Glu Lys Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Cys Gly Asp Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Thr Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Val Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ala 
                165                 170                 175     


Tyr Pro Glu Asp Ala Glu Asn Lys Glu Lys Glu Thr Ala Lys Ser 
            180                 185                 190     


<210> 7799
<211> 19
<212> PRT
<213> Homo sapiens

<400> 7799
Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val 
            


<210> 7800
<211> 341
<212> PRT
<213> Homo sapiens

<400> 7800
Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      


Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          


Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              


Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  


Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  


Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      


Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         


Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             


Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 


Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 


Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     


Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         


Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        195                 200                 205             


Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    210                 215                 220                 


Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                245                 250                 255     


Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            260                 265                 270         


Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        275                 280                 285             


Pro Glu Leu Ala Lys Thr Lys Gly Glu Leu Ile Lys Thr Lys Glu Glu 
    290                 295                 300                 


Leu Lys Lys Arg Glu Asn Glu Ser Asp Ser Leu Ile Gln Glu Leu Glu 
305                 310                 315                 320 


Thr Ser Asn Lys Lys Ile Ile Thr Gln Asn Gln Arg Ile Lys Glu Leu 
                325                 330                 335     


Ile Asn Ile Ile Asp 
            340     


<210> 7801
<211> 8
<212> PRT
<213> Homo sapiens

<400> 7801
Met Ala Asp Thr Asp Leu Phe Met 
1               5               


<210> 7802
<211> 875
<212> PRT
<213> Homo sapiens

<400> 7802
Met Met Tyr Thr Val Leu Pro Asp Gly Ser Pro Val Pro Gln Gly Met 
1               5                   10                  15      


Ala Leu Tyr Ala Pro Pro Pro Pro Leu Pro Asn Asn Ser Arg Pro Leu 
            20                  25                  30          


Thr Pro Gly Thr Val Val Tyr Gly Pro Pro Pro Ala Gly Ala Pro Met 
        35                  40                  45              


Val Tyr Gly Pro Pro Pro Pro Asn Phe Ser Ile Pro Phe Ile Pro Met 
    50                  55                  60                  


Gly Val Leu His Cys Asn Val Pro Glu His His Asn Leu Glu Asn Glu 
65                  70                  75                  80  


Val Ser Arg Leu Glu Asp Ile Met Gln His Leu Lys Ser Lys Lys Arg 
                85                  90                  95      


Glu Glu Arg Trp Met Arg Ala Ser Lys Arg Gln Ser Glu Lys Glu Met 
            100                 105                 110         


Glu Glu Leu His His Asn Ile Asp Asp Leu Leu Gln Glu Lys Lys Ser 
        115                 120                 125             


Leu Glu Cys Glu Val Glu Glu Leu His Arg Thr Val Gln Lys Arg Gln 
    130                 135                 140                 


Gln Gln Lys Asp Phe Ile Asp Gly Asn Val Glu Ser Leu Met Thr Glu 
145                 150                 155                 160 


Leu Glu Ile Glu Lys Ser Leu Lys His His Glu Asp Ile Val Asp Glu 
                165                 170                 175     


Ile Glu Cys Ile Glu Lys Thr Leu Leu Lys Arg Arg Ser Glu Leu Arg 
            180                 185                 190         


Glu Ala Asp Arg Leu Leu Ala Glu Ala Glu Ser Glu Leu Ser Cys Thr 
        195                 200                 205             


Lys Glu Lys Thr Lys Asn Ala Val Glu Lys Phe Thr Asp Ala Lys Arg 
    210                 215                 220                 


Ser Leu Leu Gln Thr Glu Ser Asp Ala Glu Glu Leu Glu Arg Arg Ala 
225                 230                 235                 240 


Gln Glu Thr Ala Val Asn Leu Val Lys Ala Asp Gln Gln Leu Arg Ser 
                245                 250                 255     


Leu Gln Ala Asp Ala Lys Asp Leu Glu Gln His Lys Ile Lys Gln Glu 
            260                 265                 270         


Glu Ile Leu Lys Glu Ile Asn Lys Ile Val Ala Ala Lys Asp Ser Asp 
        275                 280                 285             


Phe Gln Cys Leu Ser Lys Lys Lys Glu Lys Leu Thr Glu Glu Leu Gln 
    290                 295                 300                 


Lys Leu Gln Lys Asp Ile Glu Met Ala Glu Arg Asn Glu Asp His His 
305                 310                 315                 320 


Leu Gln Val Leu Lys Glu Ser Glu Val Leu Leu Gln Ala Lys Arg Ala 
                325                 330                 335     


Glu Leu Glu Lys Leu Lys Ser Gln Val Thr Ser Gln Gln Gln Glu Met 
            340                 345                 350         


Ala Val Leu Asp Arg Gln Leu Gly His Lys Lys Glu Glu Leu His Leu 
        355                 360                 365             


Leu Gln Gly Ser Met Val Gln Ala Lys Ala Asp Leu Gln Glu Ala Leu 
    370                 375                 380                 


Arg Leu Gly Glu Thr Glu Val Thr Glu Lys Cys Asn His Ile Arg Glu 
385                 390                 395                 400 


Val Lys Ser Leu Leu Glu Glu Leu Ser Phe Gln Lys Gly Glu Leu Asn 
                405                 410                 415     


Val Gln Ile Ser Glu Arg Lys Thr Gln Leu Thr Leu Ile Lys Gln Glu 
            420                 425                 430         


Ile Glu Lys Glu Glu Glu Asn Leu Gln Val Val Leu Arg Gln Met Ser 
        435                 440                 445             


Lys His Lys Thr Glu Leu Lys Asn Ile Leu Asp Met Leu Gln Leu Glu 
    450                 455                 460                 


Asn His Glu Leu Gln Gly Leu Lys Leu Gln His Asp Gln Arg Val Ser 
465                 470                 475                 480 


Glu Leu Glu Lys Thr Gln Val Ala Val Leu Glu Glu Lys Leu Glu Leu 
                485                 490                 495     


Glu Asn Leu Gln Gln Ile Ser Gln Gln Gln Lys Gly Glu Ile Glu Trp 
            500                 505                 510         


Gln Lys Gln Leu Leu Glu Arg Asp Lys Arg Glu Ile Glu Arg Met Thr 
        515                 520                 525             


Ala Glu Ser Arg Ala Leu Gln Ser Cys Val Glu Cys Leu Ser Lys Glu 
    530                 535                 540                 


Lys Glu Asp Leu Gln Glu Lys Cys Asp Ile Trp Glu Lys Lys Leu Ala 
545                 550                 555                 560 


Gln Thr Lys Arg Val Leu Ala Ala Ala Glu Glu Asn Ser Lys Met Glu 
                565                 570                 575     


Gln Ser Asn Leu Glu Lys Leu Glu Leu Asn Val Arg Lys Leu Gln Gln 
            580                 585                 590         


Glu Leu Asp Gln Leu Asn Arg Asp Lys Leu Ser Leu His Asn Asp Ile 
        595                 600                 605             


Ser Ala Met Gln Gln Gln Leu Gln Glu Lys Arg Glu Ala Val Asn Ser 
    610                 615                 620                 


Leu Gln Glu Glu Leu Ala Asn Val Gln Asp His Leu Asn Leu Ala Lys 
625                 630                 635                 640 


Gln Asp Leu Leu His Thr Thr Lys His Gln Asp Val Leu Leu Ser Glu 
                645                 650                 655     


Gln Thr Arg Leu Gln Lys Asp Ile Ser Glu Trp Ala Asn Arg Phe Glu 
            660                 665                 670         


Asp Cys Gln Lys Glu Glu Glu Thr Lys Gln Gln Gln Leu Gln Val Leu 
        675                 680                 685             


Gln Asn Glu Ile Glu Glu Asn Lys Leu Lys Leu Val Gln Gln Glu Met 
    690                 695                 700                 


Met Phe Gln Arg Leu Gln Lys Glu Arg Glu Ser Glu Glu Ser Lys Leu 
705                 710                 715                 720 


Glu Thr Ser Lys Val Thr Leu Lys Glu Gln Gln His Gln Leu Glu Lys 
                725                 730                 735     


Glu Leu Thr Asp Gln Lys Ser Lys Leu Asp Gln Val Leu Ser Lys Val 
            740                 745                 750         


Leu Ala Ala Glu Glu Arg Val Arg Thr Leu Gln Glu Glu Glu Arg Trp 
        755                 760                 765             


Cys Glu Ser Leu Glu Lys Thr Leu Ser Gln Thr Lys Arg Gln Leu Ser 
    770                 775                 780                 


Glu Arg Glu Gln Gln Leu Val Glu Lys Ser Gly Glu Leu Leu Ala Leu 
785                 790                 795                 800 


Gln Lys Glu Ala Asp Ser Met Arg Ala Asp Phe Ser Leu Leu Arg Asn 
                805                 810                 815     


Gln Phe Leu Thr Glu Arg Lys Lys Ala Glu Lys Gln Val Ala Ser Leu 
            820                 825                 830         


Lys Glu Ala Leu Lys Ile Gln Arg Ser Gln Leu Glu Lys Asn Leu Leu 
        835                 840                 845             


Thr Ala Arg Glu Ala Glu Ala Gln Lys Leu Lys Lys Gln Val Cys Ala 
    850                 855                 860                 


Gln Lys Ala Gln Leu Ala Ser Leu Gly Arg Glu 
865                 870                 875 


<210> 7803
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7803
Met Glu Pro Pro Gln Glu Thr Asn Arg Pro Phe Ser Thr Leu Asp Asn 
1               5                   10                  15      


Arg Ser Gly Gln Val Gln Val Leu Ser Ala Thr Pro Leu Leu Gln Arg 
            20                  25                  30          


Asn Pro Tyr Ser Ser Pro Asp Ile Met His Ile Lys Gly Ser Glu Ala 
        35                  40                  45              


Ser Ser Val Pro Tyr Ala Leu Asn Gln Gly Thr Thr Ala Leu Pro Lys 
    50                  55                  60                  


Asn Lys Asn Gln Glu Gly Thr Gly His Arg Leu Leu Asn Met Leu Arg 
65                  70                  75                  80  


Lys Thr Leu Lys Glu Ser Asp Ser Glu Glu Leu Glu Ile Thr Gln Glu 
                85                  90                  95      


Thr Pro Asn Leu Val Pro Phe Gly Asp Val Val Gly Cys Leu Gly Ile 
            100                 105                 110         


His Ile Lys Asn Cys Arg His Phe Met Pro Lys Ile Ser Leu Gln His 
        115                 120                 125             


Tyr Ala Asn Leu Phe Ile Arg Ile Ser Ile Asn Lys Ala Val Lys Cys 
    130                 135                 140                 


Thr Lys Met Cys Ser Leu Leu Ser Lys Asn Asp Glu Lys Asn Thr Val 
145                 150                 155                 160 


Ile Lys Phe Asp Glu Val Lys Tyr Phe Ser Val Gln Val Pro Arg Arg 
                165                 170                 175     


Tyr Asp Asp Lys Arg Asn Asn Ile Leu Leu Glu Leu Ile Gln Tyr Asp 
            180                 185                 190         


Asn Arg Glu Lys Arg Ala Phe Leu Leu Gly Ser Val Gln Ile His Leu 
        195                 200                 205             


Tyr Glu Val Ile Gln Lys Gly Cys Phe Ile Glu Glu Val Gln Val Leu 
    210                 215                 220                 


His Gly Asn Ile Phe Val Cys Arg Leu Glu Val Glu Phe Met Phe Ser 
225                 230                 235                 240 


Tyr Gly Asn Phe Gly Tyr Gly Phe Ser His Gln Leu Lys Pro Leu Gln 
                245                 250                 255     


Lys Ile Thr Glu Pro Ser Met Phe Met Asn Leu Ala Pro Pro Pro Glu 
            260                 265                 270         


Arg Thr Asp Pro Val Thr Lys Val Ile Thr Pro Gln Thr Val Glu Tyr 
        275                 280                 285             


Pro Ala Phe Leu Ser Pro Asp Leu Asn Val Thr Val Gly Thr Pro Ala 
    290                 295                 300                 


Val Gln Ser Ser Asn Gln Pro Ser Val Val Arg Leu Glu Lys Leu Gln 
305                 310                 315                 320 


Gln Gln Pro Arg Glu Arg Leu Glu Lys Met Lys Lys Glu Tyr Arg Asn 
                325                 330                 335     


Leu Asn Thr Trp Ile Asp Lys Ala Asn Tyr Leu Glu Ser Ile Leu Met 
            340                 345                 350         


Pro Lys Leu Glu His Lys Asp Ser Glu Glu Thr Asn Ile Asp Glu Ala 
        355                 360                 365             


Ser Glu Asn Thr Lys Ser Asn His Pro Glu Glu Glu Leu Glu Asn Ile 
    370                 375                 380                 


Val Gly Val Gly Gly Phe Phe Thr Lys Arg Ile 
385                 390                 395 


<210> 7804
<211> 93
<212> PRT
<213> Homo sapiens

<400> 7804
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg 
                85                  90              


<210> 7805
<211> 185
<212> PRT
<213> Homo sapiens

<400> 7805
Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Pro Val Ala Pro Ile 
            100                 105                 110         


Cys Thr Asp Lys Ile Asn Ala Ala Asn Tyr Ala Ser Val Lys Thr Pro 
        115                 120                 125             


Ala Leu Ile Val Tyr Gly Asp Gln Asp Pro Met Gly Gln Thr Ser Phe 
    130                 135                 140                 


Glu His Leu Lys Gln Leu Pro Asn His Arg Val Leu Ile Met Lys Gly 
145                 150                 155                 160 


Ala Gly His Pro Cys Tyr Leu Asp Lys Pro Glu Glu Trp His Thr Gly 
                165                 170                 175     


Leu Leu Asp Phe Leu Gln Gly Leu Gln 
            180                 185 


<210> 7806
<211> 480
<212> PRT
<213> Homo sapiens

<400> 7806
Met Leu Glu Arg Pro Pro Ala Leu Ala Met Pro Met Pro Thr Glu Gly 
1               5                   10                  15      


Thr Pro Pro Pro Leu Ser Gly Thr Pro Ile Pro Val Pro Ala Tyr Phe 
            20                  25                  30          


Arg His Ala Glu Pro Gly Phe Ser Leu Lys Arg Pro Arg Gly Leu Ser 
        35                  40                  45              


Arg Ser Leu Pro Pro Pro Pro Pro Ala Lys Gly Ser Ile Pro Ile Ser 
    50                  55                  60                  


Arg Leu Phe Pro Pro Arg Thr Pro Gly Trp His Gln Leu Gln Pro Arg 
65                  70                  75                  80  


Arg Val Ser Phe Arg Gly Glu Ala Ser Glu Thr Leu Gln Ser Pro Gly 
                85                  90                  95      


Tyr Asp Pro Ser Arg Pro Glu Ser Phe Phe Gln Gln Ser Phe Gln Arg 
            100                 105                 110         


Leu Ser Arg Leu Gly His Gly Ser Tyr Gly Glu Val Phe Lys Val Arg 
        115                 120                 125             


Ser Lys Glu Asp Gly Arg Leu Tyr Ala Val Lys Arg Ser Met Ser Pro 
    130                 135                 140                 


Phe Arg Gly Pro Lys Asp Arg Ala Arg Lys Leu Ala Glu Val Gly Ser 
145                 150                 155                 160 


His Glu Lys Val Gly Gln His Pro Cys Cys Val Arg Leu Glu Gln Ala 
                165                 170                 175     


Trp Glu Glu Gly Gly Ile Leu Tyr Leu Gln Thr Glu Leu Cys Gly Pro 
            180                 185                 190         


Ser Leu Gln Gln His Cys Glu Ala Trp Gly Ala Ser Leu Pro Glu Ala 
        195                 200                 205             


Gln Val Trp Gly Tyr Leu Arg Asp Thr Leu Leu Ala Leu Ala His Leu 
    210                 215                 220                 


His Ser Gln Gly Leu Val His Leu Asp Val Lys Pro Ala Asn Ile Phe 
225                 230                 235                 240 


Leu Gly Pro Arg Gly Arg Cys Lys Leu Gly Asp Phe Gly Leu Leu Val 
                245                 250                 255     


Glu Leu Gly Thr Ala Gly Ala Gly Glu Val Gln Glu Gly Asp Pro Arg 
            260                 265                 270         


Tyr Met Ala Pro Glu Leu Leu Gln Gly Ser Tyr Gly Thr Ala Ala Asp 
        275                 280                 285             


Val Phe Ser Leu Gly Leu Thr Ile Leu Glu Val Ala Cys Asn Met Glu 
    290                 295                 300                 


Leu Pro His Gly Gly Glu Gly Trp Gln Gln Leu Arg Gln Gly Tyr Leu 
305                 310                 315                 320 


Pro Pro Glu Phe Thr Ala Gly Leu Ser Ser Glu Leu Arg Ser Val Leu 
                325                 330                 335     


Val Met Met Leu Glu Pro Asp Pro Lys Leu Arg Ala Thr Ala Glu Ala 
            340                 345                 350         


Leu Leu Ala Leu Pro Val Leu Arg Gln Pro Arg Ala Trp Gly Val Leu 
        355                 360                 365             


Trp Cys Met Ala Ala Glu Ala Leu Ser Arg Gly Trp Ala Leu Trp Gln 
    370                 375                 380                 


Ala Leu Leu Ala Leu Leu Cys Trp Leu Trp His Gly Leu Ala His Pro 
385                 390                 395                 400 


Ala Ser Trp Leu Gln Pro Leu Gly Pro Pro Ala Thr Pro Pro Gly Ser 
                405                 410                 415     


Pro Pro Cys Ser Leu Leu Leu Asp Ser Ser Leu Ser Ser Asn Trp Asp 
            420                 425                 430         


Asp Asp Ser Leu Gly Pro Gly His Pro Pro Cys Leu Ala Cys Pro Pro 
        435                 440                 445             


Ala Gly Leu His Ser Pro Leu Arg Leu Ser Trp Pro Gly Leu Trp Gly 
    450                 455                 460                 


Ala Pro Pro Pro Pro Gly Ala Gly Ala His Pro Gly Met Pro Trp Thr 
465                 470                 475                 480 


<210> 7807
<211> 579
<212> PRT
<213> Homo sapiens

<400> 7807
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser 
                165                 170                 175     


Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser 
            180                 185                 190         


Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe 
        195                 200                 205             


Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys 
    210                 215                 220                 


Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg 
225                 230                 235                 240 


Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val 
                245                 250                 255     


Asp Val Gln Lys Ile Val Gly Ser Gln Ile His Phe His Gly Lys Lys 
            260                 265                 270         


Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His 
        275                 280                 285             


Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe 
    290                 295                 300                 


Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln 
305                 310                 315                 320 


Ile Thr Pro Asn Pro Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr 
                325                 330                 335     


Pro His Ser Pro Gly Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr 
            340                 345                 350         


Asn Tyr Gln Glu Tyr Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr 
        355                 360                 365             


Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr 
    370                 375                 380                 


Pro Arg Ser Pro Phe Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr 
385                 390                 395                 400 


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala 
                405                 410                 415     


Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr 
            420                 425                 430         


Pro Ser Ser Pro Phe Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr 
        435                 440                 445             


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala 
    450                 455                 460                 


Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr 
465                 470                 475                 480 


Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr 
                485                 490                 495     


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr 
            500                 505                 510         


Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr 
        515                 520                 525             


Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe His Val Tyr 
    530                 535                 540                 


Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln Arg Arg Asn 
545                 550                 555                 560 


Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys Leu Ile Gln 
                565                 570                 575     


Arg Arg Asp 
            


<210> 7808
<211> 324
<212> PRT
<213> Homo sapiens

<400> 7808
Met Glu Ala Leu Gly Pro Gly Gly Asp Arg Ala Ser Pro Ala Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Asp Leu Trp His Leu Ser Met Arg Ala Asp Ser Ala 
            20                  25                  30          


Tyr Ser Ser Phe Ser Ala Ala Ser Gly Gly Pro Glu Pro Arg Thr Gln 
        35                  40                  45              


Ser Pro Gly Thr Asp Leu Leu Pro Tyr Leu Asp Trp Asp Tyr Val Arg 
    50                  55                  60                  


Val Val Trp Gly Gly Pro Gly Pro Ala Pro Pro Asp Ala Ala Leu Cys 
65                  70                  75                  80  


Thr Ser Pro Arg Pro Arg Pro Ala Val Ala Ala Arg Ser Gly Pro Gln 
                85                  90                  95      


Pro Thr Glu Val Pro Gly Thr Pro Gly Pro Leu Asn Arg Gln Ala Thr 
            100                 105                 110         


Pro Leu Leu Tyr Ala Leu Ala Ala Glu Ala Glu Ala Ala Ala Gln Ala 
        115                 120                 125             


Ala Glu Pro Pro Ser Pro Pro Ala Ser Arg Ala Ala Tyr Arg Gln Arg 
    130                 135                 140                 


Leu Gln Gly Ala Gln Arg Arg Val Leu Arg Glu Thr Ser Phe Gln Arg 
145                 150                 155                 160 


Lys Glu Leu Arg Met Ser Leu Pro Ala Arg Leu Arg Pro Thr Val Pro 
                165                 170                 175     


Ala Arg Pro Pro Ala Thr His Pro Arg Ser Ala Ser Leu Ser His Pro 
            180                 185                 190         


Gly Gly Glu Gly Glu Pro Ala Arg Ser Arg Ala Pro Ala Pro Gly Thr 
        195                 200                 205             


Ala Gly Arg Gly Pro Leu Ala Asn Gln Gln Arg Lys Trp Cys Phe Ser 
    210                 215                 220                 


Glu Pro Gly Lys Leu Asp Arg Val Gly Arg Gly Gly Gly Pro Ala Arg 
225                 230                 235                 240 


Glu Cys Leu Gly Glu Ala Cys Ser Ser Ser Gly Leu Pro Gly Pro Glu 
                245                 250                 255     


Pro Leu Glu Phe Gln His Pro Ala Leu Ala Lys Phe Glu Asp His Glu 
            260                 265                 270         


Val Gly Trp Leu Pro Glu Thr Gln Pro Gln Gly Ser Met Asn Leu Asp 
        275                 280                 285             


Ser Gly Ser Leu Lys Leu Gly Asp Ala Phe Arg Pro Ala Ser Arg Ser 
    290                 295                 300                 


Arg Ser Ala Ser Gly Glu Val Leu Gly Ser Trp Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Thr Ile Pro Ile 
                


<210> 7809
<211> 259
<212> PRT
<213> Homo sapiens

<400> 7809
Met Pro Arg Ala Arg Ser Gly Arg Arg Ser Arg Gly Ala Gly Gly Arg 
1               5                   10                  15      


Glu Glu Thr Phe Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn 
            20                  25                  30          


Ala Arg Ile Gly Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Arg 
        35                  40                  45              


Glu Gly Ser Cys Met Ala Glu Asp Asp Ala Val Asp Ile Glu His Glu 
    50                  55                  60                  


Asn Asn Asn Arg Phe Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile 
65                  70                  75                  80  


Arg Ala Thr Thr Leu Leu Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile 
                85                  90                  95      


Met Cys Ser Gly Lys Glu Asn Pro Asp Ser Asp Ala Asp Leu Asp Val 
            100                 105                 110         


Asp Gly Asp Asp Thr Leu Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala 
        115                 120                 125             


Asp Val Ile Pro Cys Thr Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg 
    130                 135                 140                 


Glu Ala Leu Arg Gly Ala Val Leu Asn Gly Gly Pro Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Thr Pro Glu Phe Ser Lys Trp Ala Ser Asp Glu Met Pro Ser Thr 
                165                 170                 175     


Ser Asn Gly Glu Ser Ser Lys Gln Glu Ala Met Gln Lys Thr Cys Lys 
            180                 185                 190         


Asn Ser Asp Ile Glu Lys Ile Thr Glu Asp Ser Ala Val Thr Thr Phe 
        195                 200                 205             


Glu Ala Leu Lys Ala Arg Val Arg Glu Leu Glu Arg Gln Leu Ser Arg 
    210                 215                 220                 


Gly Asp Arg Tyr Lys Cys Leu Ile Cys Met Asp Ser Tyr Ser Met Pro 
225                 230                 235                 240 


Leu Thr Ser Ile Gln Cys Trp His Val His Cys Glu Glu Cys Trp Leu 
                245                 250                 255     


Arg Thr Leu 
            


<210> 7810
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7810
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7811
<211> 327
<212> PRT
<213> Homo sapiens

<400> 7811
Met Ala Ser Phe Leu Lys Gly Ala His Val Thr Ile Asn Ala Arg Ala 
1               5                   10                  15      


Glu Glu Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala 
            20                  25                  30          


Ser Gly Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp 
        35                  40                  45              


Val Gly Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Thr Asn Ala 
    50                  55                  60                  


Val Ser Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala 
65                  70                  75                  80  


Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu 
                85                  90                  95      


Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg 
            100                 105                 110         


Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala 
        115                 120                 125             


Ser Pro Gln Arg Thr Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn 
    130                 135                 140                 


Arg Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
145                 150                 155                 160 


Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly 
                165                 170                 175     


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr 
            180                 185                 190         


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
        195                 200                 205             


Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln 
    210                 215                 220                 


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe 
225                 230                 235                 240 


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
                245                 250                 255     


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
            260                 265                 270         


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser 
        275                 280                 285             


Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly 
    290                 295                 300                 


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
305                 310                 315                 320 


Asn Tyr Val Glu Leu Ile Glu 
                325         


<210> 7812
<211> 145
<212> PRT
<213> Homo sapiens

<400> 7812
Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu Ile 
1               5                   10                  15      


Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr Lys 
            20                  25                  30          


Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu Lys 
        35                  40                  45              


Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln Lys 
    50                  55                  60                  


Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met Arg 
65                  70                  75                  80  


Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu Leu 
                85                  90                  95      


Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met Gln 
            100                 105                 110         


Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys Lys 
        115                 120                 125             


Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys Asp 
    130                 135                 140                 


Lys 
145 


<210> 7813
<211> 271
<212> PRT
<213> Homo sapiens

<400> 7813
Met Glu Lys Glu Thr Gly Ile Ser Gln Gln Arg Asn Tyr Tyr Phe Thr 
1               5                   10                  15      


Gln Ser Lys Gly Glu Pro Leu Gln Ile Asp His Leu Val Phe Val Val 
            20                  25                  30          


His Gly Ile Gly Pro Ala Cys Asp Leu Arg Phe Arg Ser Ile Val Gln 
        35                  40                  45              


Cys Val Asn Asp Phe Arg Ser Val Ser Leu Asn Leu Leu Gln Thr His 
    50                  55                  60                  


Phe Lys Lys Ala Gln Glu Asn Gln Gln Ile Gly Arg Val Glu Phe Leu 
65                  70                  75                  80  


Pro Val Asn Trp His Ser Pro Leu His Ser Thr Gly Val Asp Val Asp 
                85                  90                  95      


Leu Gln Arg Ile Thr Leu Pro Ser Ile Asn Arg Leu Arg His Phe Thr 
            100                 105                 110         


Asn Asp Thr Ile Leu Asp Val Phe Phe Tyr Asn Ser Pro Thr Tyr Cys 
        115                 120                 125             


Gln Thr Ile Val Asp Thr Val Ala Ser Glu Met Asn Arg Ile Tyr Thr 
    130                 135                 140                 


Leu Phe Leu Gln Arg Asn Pro Asp Phe Lys Gly Gly Val Ser Ile Ala 
145                 150                 155                 160 


Gly His Ser Leu Gly Ser Leu Ile Leu Phe Asp Ile Leu Thr Asn Gln 
                165                 170                 175     


Lys Asp Ser Leu Gly Asp Ile Asp Ser Glu Lys Asp Ser Leu Asn Ile 
            180                 185                 190         


Val Met Asp Gln Gly Asp Thr Pro Thr Leu Glu Glu Asp Leu Lys Lys 
        195                 200                 205             


Leu Gln Leu Ser Glu Phe Phe Asp Ile Phe Glu Lys Glu Lys Val Asp 
    210                 215                 220                 


Lys Glu Ala Leu Ala Leu Cys Thr Asp Arg Asp Leu Gln Glu Ile Gly 
225                 230                 235                 240 


Ile Pro Leu Gly Pro Arg Lys Asn Leu Ser Ser Ala Val Ala Val Ile 
                245                 250                 255     


Leu Glu Met Val Thr Ile Trp Met Leu Ala Leu Gly Arg Cys Leu 
            260                 265                 270     


<210> 7814
<211> 605
<212> PRT
<213> Homo sapiens

<400> 7814
Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu 
1               5                   10                  15      


Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser 
            20                  25                  30          


Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His 
        35                  40                  45              


Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro 
    50                  55                  60                  


Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn 
65                  70                  75                  80  


Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val 
                85                  90                  95      


Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr 
            100                 105                 110         


Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys 
        115                 120                 125             


Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp 
    130                 135                 140                 


Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys 
145                 150                 155                 160 


Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg 
                165                 170                 175     


Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser 
            180                 185                 190         


Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val 
        195                 200                 205             


Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu 
    210                 215                 220                 


Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys 
225                 230                 235                 240 


Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe 
                245                 250                 255     


Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr 
            260                 265                 270         


Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu 
        275                 280                 285             


Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu 
    290                 295                 300                 


Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro 
305                 310                 315                 320 


Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val 
                325                 330                 335     


Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr 
            340                 345                 350         


Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe 
        355                 360                 365             


Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe 
    370                 375                 380                 


Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu 
385                 390                 395                 400 


Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys 
                405                 410                 415     


Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala 
            420                 425                 430         


Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe 
        435                 440                 445             


Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala 
    450                 455                 460                 


Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys 
465                 470                 475                 480 


Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala 
                485                 490                 495     


Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr 
            500                 505                 510         


Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly 
        515                 520                 525             


Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys 
    530                 535                 540                 


Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser 
545                 550                 555                 560 


Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser 
                565                 570                 575     


Gly Arg Ala Ile Arg Lys Arg Glu Val Glu Leu Phe Val Leu His Ser 
            580                 585                 590         


Lys Thr Gly Asp Met Ser Trp Leu Thr Gly Lys Gly Ser 
        595                 600                 605 


<210> 7815
<211> 97
<212> PRT
<213> Homo sapiens

<400> 7815
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser 
    


<210> 7816
<211> 110
<212> PRT
<213> Homo sapiens

<400> 7816
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Ile Leu 
        35                  40                  45              


Leu Arg Leu Pro Thr Thr Arg Ile His Ser Val Asn Ser Cys Pro Ala 
    50                  55                  60                  


Leu Ser His Thr Gln Ala Ser Ala Phe Ser Gly Glu Thr Leu Ala Val 
65                  70                  75                  80  


Leu Thr Ala Gly Ile Ser Lys Arg Trp Pro Lys Tyr Arg Leu Pro Ile 
                85                  90                  95      


Asp Ile Ala Arg Pro Cys Ser Glu Thr Pro Phe Pro Arg Leu 
            100                 105                 110 


<210> 7817
<211> 208
<212> PRT
<213> Homo sapiens

<400> 7817
Met Glu Pro Pro Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly Ala 
1               5                   10                  15      


Val Arg Phe Leu Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His Val 
            20                  25                  30          


Leu Asn Arg Val Pro Leu Arg Gln Leu Leu Arg Leu Gln Arg Val Ser 
        35                  40                  45              


Arg Ala Phe Arg Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg Arg 
    50                  55                  60                  


Phe Asp Ala Ala Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu Ala 
65                  70                  75                  80  


Arg Leu Leu Arg Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala Pro 
                85                  90                  95      


Cys His Glu Trp Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala Arg 
            100                 105                 110         


Asn Pro Gln Leu Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu Ser 
        115                 120                 125             


Arg Arg Ala Leu Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln Arg 
    130                 135                 140                 


Leu Ser Leu Ala His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg Gly 
145                 150                 155                 160 


Leu Ala Asp Arg Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala Cys 
                165                 170                 175     


Arg Gln Leu Lys Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg Arg Gly 
            180                 185                 190         


Ala Gly Leu Arg Ser Leu Ser Leu Ala Val Asn Ala Asn Val Gly Asp 
        195                 200                 205             


<210> 7818
<211> 472
<212> PRT
<213> Homo sapiens

<400> 7818
Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys Val Tyr Ser 
1               5                   10                  15      


Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys Leu Arg Lys 
            20                  25                  30          


Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr Ile Leu Asn 
        35                  40                  45              


Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile Gln Glu Ala 
    50                  55                  60                  


Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Val Asn Glu Lys 
65                  70                  75                  80  


Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu Pro Ile Glu 
                85                  90                  95      


Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly Asn Val Leu 
            100                 105                 110         


Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu Thr Asn Trp 
        115                 120                 125             


Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr Val Ala Thr 
    130                 135                 140                 


Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu Leu Glu Thr 
145                 150                 155                 160 


Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp Phe Gly Tyr 
                165                 170                 175     


Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala Ser Ala His 
            180                 185                 190         


Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu Ala Leu Asn 
        195                 200                 205             


Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr Ser Val Pro 
    210                 215                 220                 


Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp His Glu Lys 
225                 230                 235                 240 


Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val Pro Val Ser 
                245                 250                 255     


Val Val Ser Asn Ser Tyr Asp Ile Tyr Asn Ala Cys Glu Lys Ile Trp 
            260                 265                 270         


Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr Gln Ala Pro 
        275                 280                 285             


Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr Val Leu Lys 
    290                 295                 300                 


Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu Asn Ser Lys 
305                 310                 315                 320 


Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln Gly Asp Gly 
                325                 330                 335     


Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met Lys Gln Lys 
            340                 345                 350         


Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly Gly Leu Leu 
        355                 360                 365             


Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys Cys Ser Tyr 
    370                 375                 380                 


Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp Pro Val Ala 
385                 390                 395                 400 


Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu His Arg Thr 
                405                 410                 415     


Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly Asp Leu Glu 
            420                 425                 430         


Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn Gly Lys Val 
        435                 440                 445             


Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala Gln Leu Asn 
    450                 455                 460                 


Ile Glu Leu Glu Ala Ala His His 
465                 470         


<210> 7819
<211> 172
<212> PRT
<213> Homo sapiens

<400> 7819
Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro Thr Arg Thr 
1               5                   10                  15      


Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser 
            20                  25                  30          


Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr 
        35                  40                  45              


Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu 
    50                  55                  60                  


Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp 
65                  70                  75                  80  


Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser 
                85                  90                  95      


Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile 
            100                 105                 110         


His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg 
        115                 120                 125             


His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg 
    130                 135                 140                 


Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr Lys Gln 
145                 150                 155                 160 


His Val Leu Phe Glu Val Ile Leu Leu Leu Leu Ile 
                165                 170         


<210> 7820
<211> 814
<212> PRT
<213> Homo sapiens

<400> 7820
Met Arg Leu Leu Asp Gly Lys Gln Thr Ser Arg Tyr Ser Glu Asn Ala 
1               5                   10                  15      


Cys Glu Lys Lys Ile Phe Ser Ile Tyr Gly His Tyr Pro Val Val Arg 
            20                  25                  30          


Ala Ala Leu Arg Arg Lys Gly Trp Val Glu Lys Lys Phe His Phe Leu 
        35                  40                  45              


Pro Lys Val Ile Pro Asp Val Glu Asp Glu Gly Ala Arg Val Asn Asp 
    50                  55                  60                  


Asp Thr Cys Ala Lys Val Lys Glu Asn Gln Glu Met Ala Leu Glu Lys 
65                  70                  75                  80  


Thr Asp Asn Ile His Asp Val Met Ser Arg Leu Val Lys Asn Glu Met 
                85                  90                  95      


Pro Tyr Leu Leu Trp Thr Ile Lys Arg Asp Ile Ile Asp Tyr His Ser 
            100                 105                 110         


Leu Thr Tyr Asp Gln Met Leu Asn His Tyr Ala Lys Thr Ala Ser Phe 
        115                 120                 125             


Thr Thr Lys Ile Gly Leu Cys Val Asn Met Arg Ser Leu Pro Trp Tyr 
    130                 135                 140                 


Val Pro Ala Asn Pro Asp Ser Phe Phe Pro Arg Cys Tyr Ser Leu Cys 
145                 150                 155                 160 


Thr Glu Ser Glu Gln Gln Glu Phe Leu Glu Asp Phe Arg Arg Thr Met 
                165                 170                 175     


Ala Ser Ser Ile Leu Lys Trp Val Val Ser His Gln Ser Cys Ser Arg 
            180                 185                 190         


Ser Ser Arg Ser Lys Pro Arg Asp Gln Arg Glu Glu Ala Gly Ser Ser 
        195                 200                 205             


Asp Leu Ser Ser Arg Gln Asp Ala Glu Asn Ala Glu Ala Lys Leu Arg 
    210                 215                 220                 


Gly Leu Pro Gly Gln Leu Val Asp Ile Ala Cys Lys Val Cys Gln Ala 
225                 230                 235                 240 


Tyr Leu Gly Gln Leu Glu His Glu Asp Ile Asp Thr Ser Ala Asp Ala 
                245                 250                 255     


Val Glu Asp Leu Thr Glu Ala Glu Trp Glu Asp Leu Thr Gln Gln Tyr 
            260                 265                 270         


Tyr Ser Leu Val His Gly Asp Ala Phe Ile Ser Asn Ser Arg Asn Tyr 
        275                 280                 285             


Phe Ser Gln Cys Gln Ala Leu Leu Asn Arg Ile Thr Ser Val Asn Pro 
    290                 295                 300                 


Gln Thr Asp Ile Asp Gly Leu Arg Asn Ile Trp Ile Ile Lys Pro Ala 
305                 310                 315                 320 


Ala Lys Ser Arg Gly Arg Asp Ile Val Cys Met Asp Arg Val Glu Glu 
                325                 330                 335     


Ile Leu Glu Leu Ala Ala Ala Asp His Pro Leu Ser Arg Asp Asn Lys 
            340                 345                 350         


Trp Val Val Gln Lys Tyr Ile Glu Thr Pro Leu Leu Ile Cys Asp Thr 
        355                 360                 365             


Lys Phe Asp Ile Arg Gln Trp Phe Leu Val Thr Asp Trp Asn Pro Leu 
    370                 375                 380                 


Thr Ile Trp Phe Tyr Lys Glu Ser Tyr Leu Arg Phe Ser Thr Gln Arg 
385                 390                 395                 400 


Phe Ser Leu Asp Lys Leu Asp Ser Ala Ile His Leu Cys Asn Asn Ala 
                405                 410                 415     


Val Gln Lys Tyr Leu Lys Asn Asp Val Gly Arg Ser Pro Leu Leu Pro 
            420                 425                 430         


Ala His Asn Met Trp Thr Ser Thr Arg Phe Gln Glu Tyr Leu Gln Arg 
        435                 440                 445             


Gln Gly Arg Gly Ala Val Trp Gly Ser Val Ile Tyr Pro Ser Met Lys 
    450                 455                 460                 


Lys Ala Ile Ala His Ala Met Lys Val Ala Gln Asp His Val Glu Pro 
465                 470                 475                 480 


Arg Lys Asn Ser Phe Glu Leu Tyr Gly Ala Asp Phe Val Leu Gly Arg 
                485                 490                 495     


Asp Phe Arg Pro Trp Leu Ile Glu Ile Asn Ser Ser Pro Thr Met His 
            500                 505                 510         


Pro Ser Thr Pro Val Thr Ala Gln Leu Cys Ala Gln Val Gln Glu Asp 
        515                 520                 525             


Thr Ile Lys Val Ala Val Asp Arg Ser Cys Asp Ile Gly Asn Phe Glu 
    530                 535                 540                 


Leu Leu Trp Arg Gln Pro Val Val Glu Pro Pro Pro Phe Ser Gly Ser 
545                 550                 555                 560 


Asp Leu Cys Val Ala Gly Val Ser Val Arg Arg Ala Arg Arg Gln Val 
                565                 570                 575     


Leu Pro Val Cys Asn Leu Lys Ala Ser Ala Ser Leu Leu Asp Ala Gln 
            580                 585                 590         


Pro Leu Lys Ala Arg Gly Pro Ser Ala Met Pro Asp Pro Ala Gln Gly 
        595                 600                 605             


Pro Pro Ser Pro Ala Leu Gln Arg Asp Leu Gly Leu Lys Glu Glu Lys 
    610                 615                 620                 


Gly Leu Pro Leu Ala Leu Leu Ala Pro Leu Arg Gly Ala Ala Glu Ser 
625                 630                 635                 640 


Gly Gly Ala Ala Gln Pro Thr Arg Thr Lys Ala Ala Gly Lys Val Glu 
                645                 650                 655     


Leu Pro Ala Cys Pro Cys Arg His Val Asp Ser Gln Ala Pro Asn Thr 
            660                 665                 670         


Gly Val Pro Val Ala Gln Pro Ala Lys Ser Trp Asp Pro Asn Gln Leu 
        675                 680                 685             


Asn Ala His Pro Leu Glu Pro Val Leu Arg Gly Leu Lys Thr Ala Glu 
    690                 695                 700                 


Gly Ala Leu Arg Pro Pro Pro Gly Gly Lys Gly Glu Gly Thr Val Cys 
705                 710                 715                 720 


Ser Arg Leu Pro His His Gly His His Val Ala Ala Cys Gln Thr Thr 
                725                 730                 735     


Gly Thr Thr Trp Asp Gly Gly Pro Gly Val Cys Phe Leu Arg Gln Leu 
            740                 745                 750         


Leu Ala Ser Glu Leu Pro Met Gly Pro Gly Leu Pro Arg Asp Pro Arg 
        755                 760                 765             


Ala Pro Pro Cys Leu Val Cys Arg Gly Leu Leu Pro Pro Ala Gly Pro 
    770                 775                 780                 


Cys Lys Arg Cys Arg Ser Phe Cys Ala Ala Val Leu Gln Gly Ala Ser 
785                 790                 795                 800 


Phe Val Arg Leu Gly Gly Arg Ser Cys Ser Pro Arg Thr Pro 
                805                 810                 


<210> 7821
<211> 105
<212> PRT
<213> Homo sapiens

<400> 7821
Met Asp Lys Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe 
1               5                   10                  15      


Arg Gln Ala Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln 
            20                  25                  30          


Lys Thr Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu 
        35                  40                  45              


Ser Leu Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu 
    50                  55                  60                  


Val Asn Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu 
65                  70                  75                  80  


Asp Ser Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp 
                85                  90                  95      


Lys Val Ile Ser Gly Ile Ala Arg Glu 
            100                 105 


<210> 7822
<211> 271
<212> PRT
<213> Homo sapiens

<400> 7822
Met Ala Pro Val Gly Val Glu Lys Lys Leu Leu Leu Gly Pro Asn Gly 
1               5                   10                  15      


Pro Ala Val Ala Ala Ala Gly Asp Leu Thr Ser Glu Glu Glu Glu Gly 
            20                  25                  30          


Gln Ser Leu Trp Ser Ser Ile Leu Ser Glu Val Ser Thr Arg Ala Arg 
        35                  40                  45              


Ser Lys Leu Pro Ser Gly Lys Asn Ile Leu Val Phe Asp His Thr Arg 
    50                  55                  60                  


Cys Asn Val Trp Ile Leu Asp Gly Asp Leu Tyr His Lys Gly Leu Leu 
65                  70                  75                  80  


Lys Phe Ala Val Ser Ala Glu Ser Leu Pro Glu Thr Leu Val Ile Phe 
                85                  90                  95      


Val Ala Asp Met Ser Arg Pro Trp Thr Val Met Glu Ser Leu Gln Lys 
            100                 105                 110         


Trp Ala Ser Val Leu Arg Glu His Ile Asp Lys Met Lys Ile Pro Pro 
        115                 120                 125             


Glu Lys Met Arg Glu Leu Glu Arg Lys Phe Val Lys Asp Phe Gln Asp 
    130                 135                 140                 


Tyr Met Glu Pro Glu Glu Gly Cys Gln Gly Ser Pro Gln Arg Arg Gly 
145                 150                 155                 160 


Pro Leu Thr Ser Gly Ser Asp Glu Glu Asn Val Ala Leu Pro Leu Gly 
                165                 170                 175     


Asp Asn Val Leu Thr His Asn Leu Gly Ile Pro Val Leu Val Val Cys 
            180                 185                 190         


Thr Lys Cys Asp Ala Val Ser Val Leu Glu Lys Glu His Asp Tyr Arg 
        195                 200                 205             


Asp Glu His Leu Asp Phe Ile Gln Ser His Leu Arg Arg Phe Cys Leu 
    210                 215                 220                 


Gln Tyr Gly Ala Ala Leu Ile Tyr Thr Ser Val Lys Glu Glu Lys Asn 
225                 230                 235                 240 


Leu Asp Leu Leu Tyr Lys Tyr Ile Val His Lys Thr Tyr Gly Phe His 
                245                 250                 255     


Phe Thr Thr Pro Ala Leu Val Val Glu Lys Asp Ala Val Phe Met 
            260                 265                 270     


<210> 7823
<211> 173
<212> PRT
<213> Homo sapiens

<400> 7823
Met Ala Asp Arg Met Gln Ile Val Val Ile Leu Ser Glu Phe Phe Asn 
1               5                   10                  15      


Thr Thr Trp Gln Glu Ala Asn Cys Ala Asn Cys Leu Thr Asn Asn Ser 
            20                  25                  30          


Glu Glu Leu Ser Asn Ser Thr Val Tyr Phe Leu Asn Leu Phe Asn His 
        35                  40                  45              


Thr Leu Thr Cys Phe Glu His Asn Leu Gln Gly Asn Ala His Ser Leu 
    50                  55                  60                  


Leu Gln Thr Lys Asn Tyr Ser Glu Val Cys Lys Asn Cys Arg Glu Ala 
65                  70                  75                  80  


Tyr Lys Thr Leu Ser Ser Leu Tyr Ser Glu Met Gln Lys Met Asn Glu 
                85                  90                  95      


Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu Cys Ile Asp Val Glu 
            100                 105                 110         


Asp Ala Met Asn Ile Thr Arg Lys Leu Trp Ser Arg Thr Phe Asn Cys 
        115                 120                 125             


Ser Val Pro Cys Ser Asp Thr Val Pro Val Ile Ala Val Ser Val Phe 
    130                 135                 140                 


Ile Leu Phe Leu Pro Val Val Phe Tyr Leu Ser Ser Phe Leu His Ser 
145                 150                 155                 160 


Glu Gln Lys Lys Arg Lys Leu Ile Leu Pro Lys Arg Leu 
                165                 170             


<210> 7824
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7824
Xaa Phe Ile His Cys Thr Asp Asp Ser Pro Asp Pro Cys Ile Glu Tyr 
1               5                   10                  15      


Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala Glu Phe 
            20                  25                  30          


Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln Arg Asp 
        35                  40                  45              


Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu Ile Arg 
    50                  55                  60                  


Arg Cys Ile Gln Asp Phe Phe Lys Lys His Ile Gln Tyr Lys Phe Leu 
65                  70                  75                  80  


Asp Glu Asp Phe Val Phe Asp Ile Tyr Arg Asp Ser Arg Gly Lys Val 
                85                  90                  95      


Trp Leu Ile Asp Phe Asn Pro Phe Gly Glu Val Thr Asp Ser Leu Leu 
            100                 105                 110         


Phe Thr Trp Glu Glu Leu Ile Ser Glu Asn Asn Leu Asn Gly Asp Phe 
        115                 120                 125             


Ser Glu Val Asp Ala Gln Glu Gln Lys Arg Asn Gln Gln Glu Asp Asp 
    130                 135                 140                 


<210> 7825
<211> 325
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7825
Xaa Ile Gln Gly Glu Ala Ser Arg Arg Ala Ala Gly Glu Pro Glu Ala 
1               5                   10                  15      


Gly Ser Asp Tyr Val Lys Phe Ser Lys Glu Lys Tyr Ile Leu Asp Ser 
            20                  25                  30          


Ser Pro Glu Lys Leu His Lys Glu Leu Glu Glu Glu Leu Lys Leu Ser 
        35                  40                  45              


Ser Thr Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro Arg 
    50                  55                  60                  


Glu Val Ser Glu Thr Leu Val Gln Arg Asn Gly Asp Phe Leu Ile Arg 
65                  70                  75                  80  


Asp Ser Leu Thr Ser Leu Gly Asp Tyr Val Leu Thr Cys Arg Trp Arg 
                85                  90                  95      


Asn Gln Ala Leu His Phe Lys Ile Asn Lys Val Val Val Lys Ala Gly 
            100                 105                 110         


Glu Ser Tyr Thr His Ile Gln Tyr Leu Phe Glu Gln Glu Ser Phe Asp 
        115                 120                 125             


His Val Pro Ala Leu Val Arg Tyr His Val Gly Ser Arg Lys Ala Val 
    130                 135                 140                 


Ser Glu Gln Ser Gly Ala Ile Ile Tyr Cys Pro Val Asn Arg Thr Phe 
145                 150                 155                 160 


Pro Leu Arg Tyr Leu Glu Ala Ser Tyr Gly Leu Gly Gln Gly Ser Ser 
                165                 170                 175     


Lys Pro Ala Ser Pro Val Ser Pro Ser Gly Pro Lys Gly Ser His Met 
            180                 185                 190         


Lys Arg Arg Ser Val Thr Met Thr Asp Gly Leu Thr Ala Asp Lys Val 
        195                 200                 205             


Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr Ser Leu Pro Arg Pro Arg 
    210                 215                 220                 


Asp Ser Ile Arg Ser Cys Ala Leu Ser Met Asp Gln Ile Pro Asp Leu 
225                 230                 235                 240 


His Ser Pro Met Ser Pro Ile Ser Glu Ser Pro Ser Ser Pro Ala Tyr 
                245                 250                 255     


Ser Thr Val Thr Arg Val His Ala Ala Pro Ala Ala Pro Ser Ala Thr 
            260                 265                 270         


Ala Leu Pro Ala Ser Pro Val Ala Arg Arg Ser Ser Glu Pro Gln Leu 
        275                 280                 285             


Cys Pro Gly Ser Ala Pro Lys Thr His Gly Glu Ser Asp Lys Gly Pro 
    290                 295                 300                 


His Thr Ser Pro Ser His Thr Leu Gly Lys Ala Ser Pro Ser Pro Ser 
305                 310                 315                 320 


Leu Ser Ser Tyr Ser 
                325 


<210> 7826
<211> 109
<212> PRT
<213> Homo sapiens

<400> 7826
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Thr Glu Ser 
    50                  55                  60                  


Arg Gly Thr Asp Thr Glu Ser Ser Gly Glu Asp Lys Asp Ser Asp Ser 
65                  70                  75                  80  


Met Glu Asp Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His 
                85                  90                  95      


Asp Arg Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            100                 105                 


<210> 7827
<211> 545
<212> PRT
<213> Homo sapiens

<400> 7827
Ala Ala Gly Ala Pro Arg Leu Leu Gly Pro Gly Ala Val Arg Gly Pro 
1               5                   10                  15      


Ala Gly Val Gly Arg Val Ala Ala Gly Ala Met Glu Gly Val Leu Tyr 
            20                  25                  30          


Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln Pro Arg Trp Phe Leu Leu 
        35                  40                  45              


Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser Pro Glu Asp Ala Trp Lys 
    50                  55                  60                  


Gly Cys Lys Gly Ser Ile Gln Met Ala Val Cys Glu Ile Gln Val His 
65                  70                  75                  80  


Ser Val Asp Asn Thr Arg Met Asp Leu Ile Ile Pro Gly Glu Gln Tyr 
                85                  90                  95      


Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu Arg Gln Arg Trp Leu Val 
            100                 105                 110         


Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr Asp Ser Arg Thr Gln Lys 
        115                 120                 125             


Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn Leu Lys Thr Lys Met Ser 
    130                 135                 140                 


Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val Gln Gln Val Asp Lys Thr 
145                 150                 155                 160 


Lys Glu Val Thr Thr Thr Gly Val Ser Asn Ser Glu Glu Gly Ile Asp 
                165                 170                 175     


Val Gly Thr Leu Leu Lys Ser Thr Cys Asn Thr Phe Leu Lys Thr Leu 
            180                 185                 190         


Glu Glu Cys Met Gln Ile Ala Asn Ala Ala Phe Thr Ser Glu Leu Leu 
        195                 200                 205             


Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu Ala Met Leu Lys Ser Ser 
    210                 215                 220                 


Lys Met Lys His Pro Ile Ile Pro Ile His Asn Ser Leu Glu Arg Gln 
225                 230                 235                 240 


Met Glu Leu Ser Thr Cys Glu Asn Gly Ser Leu Asn Met Glu Ile Asn 
                245                 250                 255     


Gly Glu Glu Glu Ile Leu Met Lys Asn Lys Asn Ser Leu Tyr Leu Lys 
            260                 265                 270         


Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser Glu Glu Asn Thr Asp Asp 
        275                 280                 285             


Asn Ile Thr Val Gln Gly Glu Ile Arg Lys Glu Asp Gly Met Glu Asn 
    290                 295                 300                 


Leu Lys Asn His Asp Asn Asn Leu Thr Gln Ser Gly Ser Asp Ser Ser 
305                 310                 315                 320 


Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly Lys Glu Val Ile Pro Thr 
                325                 330                 335     


Phe Phe Ser Thr Met Asn Thr Ser Phe Ser Asp Ile Glu Leu Leu Glu 
            340                 345                 350         


Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu Ala Ser Cys Tyr Ala Val 
        355                 360                 365             


Val Pro Val Leu Asp Lys Leu Gly Pro Thr Val Phe Ala Pro Val Lys 
    370                 375                 380                 


Met Asp Leu Val Gly Asn Ile Lys Lys Val Asn Gln Lys Tyr Ile Thr 
385                 390                 395                 400 


Asn Lys Glu Glu Phe Thr Thr Leu Gln Lys Ile Val Leu His Glu Val 
                405                 410                 415     


Glu Ala Asp Val Ala Gln Val Arg Asn Ser Ala Thr Glu Ala Leu Leu 
            420                 425                 430         


Trp Leu Lys Arg Gly Leu Lys Phe Leu Lys Gly Phe Leu Thr Glu Val 
        435                 440                 445             


Lys Asn Gly Glu Lys Asp Ile Gln Thr Ala Leu Asn Asn Ala Tyr Gly 
    450                 455                 460                 


Lys Thr Leu Arg Gln His His Gly Trp Val Val Arg Gly Val Phe Ala 
465                 470                 475                 480 


Leu Ala Leu Arg Ala Ala Pro Ser Tyr Glu Asp Phe Val Ala Ala Leu 
                485                 490                 495     


Thr Val Lys Glu Gly Asp His Gln Lys Glu Ala Phe Ser Ile Gly Met 
            500                 505                 510         


Gln Arg Asp Leu Ser Leu Tyr Leu Pro Ala Met Glu Lys Gln Leu Ala 
        515                 520                 525             


Ile Leu Asp Thr Leu Tyr Glu Val His Gly Leu Glu Ser Asp Glu Val 
    530                 535                 540                 


Val 
545 


<210> 7828
<211> 173
<212> PRT
<213> Homo sapiens

<400> 7828
Met Tyr Thr Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
1               5                   10                  15      


Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
            20                  25                  30          


Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys Asn Tyr Lys Gly Met 
        35                  40                  45              


Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu Asn Ile Gly Thr Val 
    50                  55                  60                  


Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
65                  70                  75                  80  


Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                85                  90                  95      


Ile Tyr Val Ile Asp Ser Thr Asp Glu Glu Arg Leu Ala Glu Ser Lys 
            100                 105                 110         


Gln Ala Phe Glu Lys Val Val Thr Ser Glu Ala Leu Cys Gly Val Pro 
        115                 120                 125             


Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Thr Cys Leu Ser Ile 
    130                 135                 140                 


Pro Asp Ile Lys Thr Ala Phe Ser Asp Cys Thr Ser Lys Ile Gly Arg 
145                 150                 155                 160 


Arg Asp Cys Leu Thr Gln Ala Cys Ser Ala Leu Thr Gly 
                165                 170             


<210> 7829
<211> 242
<212> PRT
<213> Homo sapiens

<400> 7829
Met Gly Leu Val Cys Val Leu Gly Asp Gly Lys Thr Glu Gln Lys Gly 
1               5                   10                  15      


Gly Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg 
            20                  25                  30          


Gly Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser 
        35                  40                  45              


Pro Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val 
    50                  55                  60                  


Val Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg 
65                  70                  75                  80  


Asp Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu 
                85                  90                  95      


Trp Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys 
            100                 105                 110         


Phe Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr 
        115                 120                 125             


Lys Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr 
    130                 135                 140                 


Ser Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu 
145                 150                 155                 160 


Lys Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys 
                165                 170                 175     


Phe Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp 
            180                 185                 190         


Glu Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala 
        195                 200                 205             


Phe Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His 
    210                 215                 220                 


Val Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu 
225                 230                 235                 240 


Lys Pro 
        


<210> 7830
<211> 973
<212> PRT
<213> Homo sapiens

<400> 7830
Ser Ser Ser Asp Lys Glu Ser Ile Leu Thr Ile Leu Lys Val Leu Gly 
1               5                   10                  15      


Asp Leu Leu Ser Val Gly Thr Asp Arg Arg Ile His Tyr Met Ile Ser 
            20                  25                  30          


Lys Gly Gly Ser Glu Ala Leu Leu Gln Thr Leu Val Asp Thr Ala Arg 
        35                  40                  45              


Thr Ala Pro Pro Asp Tyr Asp Ile Leu Leu Pro Leu Phe Arg Leu Leu 
    50                  55                  60                  


Ala Lys Val Gly Leu Arg Asp Lys Lys Ile Gly Arg Lys Ala Leu Glu 
65                  70                  75                  80  


Leu Glu Ala Leu Asp Val Thr Leu Ile Leu Ala Arg Lys Asn Leu Ser 
                85                  90                  95      


His Gly Gln Asn Leu Leu His Cys Leu Trp Ala Leu Arg Val Phe Ala 
            100                 105                 110         


Ser Ser Val Ser Met Gly Ala Met Leu Gly Ile Asn Gly Ala Met Glu 
        115                 120                 125             


Leu Leu Phe Lys Val Ile Thr Pro Tyr Thr Arg Lys Arg Thr Gln Ala 
    130                 135                 140                 


Ile Arg Ala Ala Thr Glu Val Leu Ala Ala Leu Leu Lys Ser Lys Ser 
145                 150                 155                 160 


Asn Gly Arg Arg Ala Val Asn Arg Gly Tyr Val Thr Ser Leu Leu Gly 
                165                 170                 175     


Leu His Gln Asp Trp His Ser His Asp Thr Ala Asn Ala Tyr Val Gln 
            180                 185                 190         


Ile Arg Arg Gly Leu Leu Leu Cys Leu Arg His Ile Ala Ala Leu Arg 
        195                 200                 205             


Ser Gly Arg Glu Ala Phe Leu Ala Ala Gln Gly Met Glu Ile Leu Phe 
    210                 215                 220                 


Ser Thr Thr Gln Asn Cys Leu Asp Asp Lys Ser Met Glu Pro Val Ile 
225                 230                 235                 240 


Ser Val Val Leu Gln Ile Leu Arg Gln Cys Tyr Pro Thr Ser Pro Leu 
                245                 250                 255     


Pro Leu Val Thr Ala Ser Ser Ala Tyr Ala Phe Pro Val Pro Gly Cys 
            260                 265                 270         


Ile Thr Thr Glu Pro Pro His Asp Leu Pro Glu Glu Asp Phe Glu Asp 
        275                 280                 285             


Asp Gly Asp Asp Glu Val Asp Lys Asp Ser Asp Thr Glu Asp Gly Lys 
    290                 295                 300                 


Val Glu Asp Asp Asp Leu Glu Thr Asp Val Asn Lys Leu Ser Ser Lys 
305                 310                 315                 320 


Pro Gly Leu Asp Arg Pro Glu Glu Glu Leu Met Gln Tyr Glu Val Met 
                325                 330                 335     


Cys Leu Glu Leu Ser Tyr Ser Phe Glu Glu Leu Gln Ser Lys Leu Gly 
            340                 345                 350         


Asp Asp Leu Asn Ser Glu Lys Thr Gln Tyr Ala Asn His His His Ile 
        355                 360                 365             


Pro Ala Ala Ala Ser Ser Lys Gln His Cys Tyr Ser Lys Asp Gln Ser 
    370                 375                 380                 


Ser Cys Gly Gln Glu Arg Glu Tyr Ala Val Gln Thr Ser Leu Leu Cys 
385                 390                 395                 400 


Arg Val Lys Thr Gly Arg Ser Thr Val His Leu Gly Ser Lys Lys Asn 
                405                 410                 415     


Pro Gly Val Asn Leu Tyr Gln Asn Val Gln Ser Asn Ser Leu Arg Arg 
            420                 425                 430         


Asp Ser Ser Glu Ser Glu Ile Pro Asp Ile Gln Ala Ser Pro Lys Ala 
        435                 440                 445             


Asp Ala Trp Asp Val Asp Ala Ile Phe Cys Pro Arg Met Ser Ala Ser 
    450                 455                 460                 


Phe Ser Asn Ser Thr Arg Thr Arg Glu Val Val Lys Val Ile Asp Lys 
465                 470                 475                 480 


Leu Leu Gln Thr His Leu Lys Arg Val Pro Phe His Asp Pro Tyr Leu 
                485                 490                 495     


Tyr Met Ala Lys Ala Arg Arg Thr Ser Ser Val Val Asp Phe Lys Met 
            500                 505                 510         


Met Ala Phe Pro Asp Val Trp Gly His Cys Pro Pro Pro Thr Thr Gln 
        515                 520                 525             


Pro Met Leu Glu Arg Lys Cys Gly Val Gln Arg Ile Arg Ile Phe Glu 
    530                 535                 540                 


Asp Ile Arg Arg Leu Ile Gln Pro Ser Asp Val Ile Asn Lys Val Val 
545                 550                 555                 560 


Phe Ser Leu Asp Glu Pro Trp Pro Leu Gln Asp Asn Ala Ser Asn Cys 
                565                 570                 575     


Leu Arg Phe Phe Ser Lys Phe Glu Ser Gly Asn Leu Arg Lys Ala Ile 
            580                 585                 590         


Gln Val Arg Glu Phe Glu Tyr Asp Leu Leu Val Asn Ala Asp Val Asn 
        595                 600                 605             


Ser Thr Gln His Gln Gln Trp Phe Tyr Phe Lys Val Ser Gly Met Gln 
    610                 615                 620                 


Ala Ala Ile Pro Tyr His Phe Asn Ile Ile Asn Cys Glu Lys Pro Asn 
625                 630                 635                 640 


Ser Gln Phe Asn Tyr Gly Met Gln Pro Thr Leu Tyr Ser Val Lys Glu 
                645                 650                 655     


Ala Leu Leu Gly Lys Pro Thr Trp Ile Arg Thr Gly His Glu Ile Cys 
            660                 665                 670         


Tyr Tyr Lys Asn His Tyr Arg Gln Ser Thr Ala Val Ala Gly Gly Ala 
        675                 680                 685             


Ser Gly Lys Cys Tyr Tyr Thr Leu Thr Phe Ala Val Thr Phe Pro His 
    690                 695                 700                 


Ser Glu Asp Val Cys Tyr Leu Ala Tyr His Tyr Pro Tyr Thr Tyr Thr 
705                 710                 715                 720 


Ala Leu Met Thr His Leu Asp Ile Leu Glu Lys Ser Val Asn Leu Lys 
                725                 730                 735     


Glu Val Tyr Phe Arg Gln Asp Val Leu Cys Gln Thr Leu Gly Gly Asn 
            740                 745                 750         


Pro Cys Pro Leu Val Thr Ile Thr Ala Met Pro Glu Ser Asn Ser Asp 
        755                 760                 765             


Glu His Leu Glu Gln Phe Arg His Arg Pro Tyr Gln Val Ile Thr Ala 
    770                 775                 780                 


Arg Val His Pro Gly Glu Ser Asn Ala Ser Trp Val Met Lys Gly Thr 
785                 790                 795                 800 


Leu Glu Phe Leu Val Ser Ser Asp Pro Val Ala Arg Leu Leu Arg Glu 
                805                 810                 815     


Asn Phe Ile Phe Lys Ile Ile Pro Met Leu Asn Pro Asp Gly Val Ile 
            820                 825                 830         


Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu Asp Leu Asn Arg Gln 
        835                 840                 845             


Trp Leu Ser Pro Ser Ala His Leu Gln Pro Thr Ile Tyr His Ala Lys 
    850                 855                 860                 


Gly Leu Leu Tyr His Leu Ser Ser Ile Gly Arg Ser Pro Val Val Ser 
865                 870                 875                 880 


His Phe Leu Leu Val Phe Cys Asp Phe His Gly His Ser Gln Lys Lys 
                885                 890                 895     


Asn Val Phe Leu Tyr Gly Cys Ser Ile Lys Glu Thr Leu Trp Gln Ala 
            900                 905                 910         


Ala Cys Thr Val Gly Thr Ser Thr Ile Leu Glu Glu Val Asn Tyr Arg 
        915                 920                 925             


Thr Leu Pro Lys Ile Leu Asp Lys Leu Ala Pro Ala Phe Thr Met Ser 
    930                 935                 940                 


Ser Cys Ser Phe Leu Val Glu Lys Ser Arg Ala Ser Thr Ala Arg Val 
945                 950                 955                 960 


Val Val Trp Arg Glu Met Gly Val Ser Arg Ser Tyr Thr 
                965                 970             


<210> 7831
<211> 2583
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7831
Xaa Ser Ser Ile Thr Phe Ser Val Lys Val Glu Gly Arg Pro Val Pro 
1               5                   10                  15      


Thr Val His Trp Leu Arg Glu Glu Ala Glu Arg Gly Val Leu Trp Ile 
            20                  25                  30          


Gly Pro Asp Thr Pro Gly Tyr Thr Val Ala Ser Ser Ala Gln Gln His 
        35                  40                  45              


Ser Leu Val Leu Leu Asp Val Gly Arg Gln His Gln Gly Thr Tyr Thr 
    50                  55                  60                  


Cys Ile Ala Ser Asn Ala Ala Gly Gln Ala Leu Cys Ser Ala Ser Leu 
65                  70                  75                  80  


His Val Ser Gly Leu Pro Lys Val Glu Glu Gln Glu Lys Val Lys Glu 
                85                  90                  95      


Ala Leu Ile Ser Thr Phe Leu Gln Gly Thr Thr Gln Ala Ile Ser Ala 
            100                 105                 110         


Gln Gly Leu Glu Thr Ala Ser Phe Ala Asp Leu Gly Gly Gln Arg Lys 
        115                 120                 125             


Glu Glu Pro Leu Ala Ala Lys Glu Ala Leu Gly His Leu Ser Leu Ala 
    130                 135                 140                 


Glu Val Gly Thr Glu Glu Phe Leu Gln Lys Leu Thr Ser Gln Ile Thr 
145                 150                 155                 160 


Glu Met Val Ser Ala Lys Ile Thr Gln Ala Lys Leu Gln Val Pro Gly 
                165                 170                 175     


Gly Asp Ser Asp Glu Asp Ser Lys Thr Pro Ser Ala Ser Pro Arg His 
            180                 185                 190         


Gly Arg Ser Arg Pro Ser Ser Ser Ile Gln Glu Ser Ser Ser Glu Ser 
        195                 200                 205             


Glu Asp Gly Asp Ala Arg Gly Glu Ile Phe Asp Ile Tyr Val Val Thr 
    210                 215                 220                 


Ala Asp Tyr Leu Pro Leu Gly Ala Glu Gln Asp Ala Ile Thr Leu Arg 
225                 230                 235                 240 


Glu Gly Gln Tyr Val Glu Val Leu Asp Ala Ala His Pro Leu Arg Trp 
                245                 250                 255     


Leu Val Arg Thr Lys Pro Thr Lys Ser Ser Pro Ser Arg Gln Gly Trp 
            260                 265                 270         


Val Ser Pro Ala Tyr Leu Asp Arg Arg Leu Lys Leu Ser Pro Glu Trp 
        275                 280                 285             


Gly Ala Ala Glu Ala Pro Glu Phe Pro Gly Glu Ala Val Ser Glu Asp 
    290                 295                 300                 


Glu Tyr Lys Ala Arg Leu Ser Ser Val Ile Gln Glu Leu Leu Ser Ser 
305                 310                 315                 320 


Glu Gln Ala Phe Val Glu Glu Leu Gln Phe Leu Gln Ser His His Leu 
                325                 330                 335     


Gln His Leu Glu Arg Cys Pro His Val Pro Ile Ala Val Ala Gly Gln 
            340                 345                 350         


Lys Ala Val Ile Phe Arg Asn Val Arg Asp Ile Gly Arg Phe His Ser 
        355                 360                 365             


Ser Ser Phe Leu Gln Glu Leu Gln Gln Cys Asp Thr Asp Asp Asp Val 
    370                 375                 380                 


Ala Met Cys Phe Ile Lys Asn Gln Ala Ala Phe Glu Gln Tyr Leu Glu 
385                 390                 395                 400 


Phe Leu Val Gly Arg Val Gln Ala Glu Ser Val Val Val Ser Thr Ala 
                405                 410                 415     


Ile Gln Glu Phe Tyr Lys Lys Tyr Ala Glu Glu Ala Leu Leu Ala Gly 
            420                 425                 430         


Asp Pro Ser Gln Pro Pro Pro Pro Pro Leu Gln His Tyr Leu Glu Gln 
        435                 440                 445             


Pro Val Glu Arg Val Gln Arg Tyr Gln Ala Leu Leu Lys Glu Leu Ile 
    450                 455                 460                 


Arg Asn Lys Ala Arg Asn Arg Gln Asn Cys Ala Leu Leu Glu Gln Ala 
465                 470                 475                 480 


Tyr Ala Val Val Ser Ala Leu Pro Gln Arg Ala Glu Asn Lys Leu His 
                485                 490                 495     


Val Ser Leu Met Glu Asn Tyr Pro Gly Thr Leu Gln Ala Leu Gly Glu 
            500                 505                 510         


Pro Ile Arg Gln Gly His Phe Ile Val Trp Glu Gly Ala Pro Gly Ala 
        515                 520                 525             


Arg Met Pro Trp Lys Gly His Asn Arg His Val Phe Leu Phe Arg Asn 
    530                 535                 540                 


His Leu Val Ile Cys Lys Pro Arg Arg Asp Ser Arg Thr Asp Thr Val 
545                 550                 555                 560 


Ser Tyr Val Phe Arg Asn Met Met Lys Leu Ser Ser Ile Asp Leu Asn 
                565                 570                 575     


Asp Gln Val Glu Gly Asp Asp Arg Ala Phe Glu Val Trp Gln Glu Arg 
            580                 585                 590         


Glu Asp Ser Val Arg Lys Tyr Leu Leu Gln Ala Arg Thr Ala Ile Ile 
        595                 600                 605             


Lys Ser Ser Trp Val Lys Glu Ile Cys Gly Ile Gln Gln Arg Leu Ala 
    610                 615                 620                 


Leu Pro Val Trp Arg Pro Pro Asp Phe Glu Glu Glu Leu Ala Asp Cys 
625                 630                 635                 640 


Thr Ala Glu Leu Gly Glu Thr Val Lys Leu Ala Cys Arg Val Thr Gly 
                645                 650                 655     


Thr Pro Lys Pro Val Ile Ser Trp Tyr Lys Asp Gly Lys Ala Val Gln 
            660                 665                 670         


Val Asp Pro His His Ile Leu Ile Glu Asp Pro Asp Gly Ser Cys Ala 
        675                 680                 685             


Leu Ile Leu Asp Ser Leu Thr Gly Val Asp Ser Gly Gln Tyr Met Cys 
    690                 695                 700                 


Phe Ala Ala Ser Ala Ala Gly Asn Cys Ser Thr Leu Gly Lys Ile Leu 
705                 710                 715                 720 


Val Gln Val Pro Pro Arg Phe Val Asn Lys Val Arg Ala Ser Pro Phe 
                725                 730                 735     


Val Glu Gly Glu Asp Ala Gln Phe Thr Cys Thr Ile Glu Gly Ala Pro 
            740                 745                 750         


Tyr Pro Gln Ile Arg Trp Tyr Lys Asp Gly Ala Leu Leu Thr Thr Gly 
        755                 760                 765             


Asn Lys Phe Gln Thr Leu Ser Glu Pro Arg Ser Gly Leu Leu Val Leu 
    770                 775                 780                 


Val Ile Arg Ala Ala Ser Lys Glu Asp Leu Gly Leu Tyr Glu Cys Glu 
785                 790                 795                 800 


Leu Val Asn Arg Leu Gly Ser Ala Arg Ala Ser Ala Glu Leu Arg Ile 
                805                 810                 815     


Gln Ser Pro Met Leu Gln Ala Gln Glu Gln Cys His Arg Glu Gln Leu 
            820                 825                 830         


Val Ala Ala Val Glu Asp Thr Thr Leu Glu Arg Ala Asp Gln Glu Val 
        835                 840                 845             


Thr Ser Val Leu Lys Arg Leu Leu Gly Pro Lys Ala Pro Gly Pro Ser 
    850                 855                 860                 


Thr Gly Asp Leu Thr Gly Pro Gly Pro Cys Pro Arg Gly Ala Pro Ala 
865                 870                 875                 880 


Leu Gln Glu Thr Gly Ser Gln Pro Pro Val Thr Gly Thr Ser Glu Ala 
                885                 890                 895     


Pro Ala Val Pro Pro Arg Val Pro Gln Pro Leu Leu His Glu Gly Pro 
            900                 905                 910         


Glu Gln Glu Pro Glu Ala Ile Ala Arg Ala Gln Glu Trp Thr Val Pro 
        915                 920                 925             


Ile Arg Met Glu Gly Ala Ala Trp Pro Gly Ala Gly Thr Gly Glu Leu 
    930                 935                 940                 


Leu Trp Asp Val His Ser His Val Val Arg Glu Thr Thr Gln Arg Thr 
945                 950                 955                 960 


Tyr Thr Tyr Gln Ala Ile Asp Thr His Thr Ala Arg Pro Pro Ser Met 
                965                 970                 975     


Gln Val Thr Ile Glu Asp Val Gln Ala Gln Thr Gly Gly Thr Ala Gln 
            980                 985                 990         


Phe Glu Ala Ile Ile Glu Gly Asp  Pro Gln Pro Ser Val  Thr Trp Tyr 
        995                 1000                 1005             


Lys Asp  Ser Val Gln Leu Val  Asp Ser Thr Arg Leu  Ser Gln Gln 
    1010                 1015                 1020             


Gln Glu  Gly Thr Thr Tyr Ser  Leu Val Leu Arg His  Val Ala Ser 
    1025                 1030                 1035             


Lys Asp  Ala Gly Val Tyr Thr  Cys Leu Ala Gln Asn  Thr Gly Gly 
    1040                 1045                 1050             


Gln Val  Leu Cys Lys Ala Glu  Leu Leu Val Leu Gly  Gly Asp Asn 
    1055                 1060                 1065             


Glu Pro  Asp Ser Glu Lys Gln  Ser His Arg Arg Lys  Leu His Ser 
    1070                 1075                 1080             


Phe Tyr  Glu Val Lys Glu Glu  Ile Gly Arg Gly Val  Phe Gly Phe 
    1085                 1090                 1095             


Val Lys  Arg Val Gln His Lys  Gly Asn Lys Ile Leu  Cys Ala Ala 
    1100                 1105                 1110             


Lys Phe  Ile Pro Leu Arg Ser  Arg Thr Arg Ala Gln  Ala Tyr Arg 
    1115                 1120                 1125             


Glu Arg  Asp Ile Leu Ala Ala  Leu Ser His Pro Leu  Val Thr Gly 
    1130                 1135                 1140             


Leu Leu  Asp Gln Phe Glu Thr  Arg Lys Thr Leu Ile  Leu Ile Leu 
    1145                 1150                 1155             


Glu Leu  Cys Ser Ser Glu Glu  Leu Leu Asp Arg Leu  Tyr Arg Lys 
    1160                 1165                 1170             


Gly Val  Val Thr Glu Ala Glu  Val Lys Val Tyr Ile  Gln Gln Leu 
    1175                 1180                 1185             


Val Glu  Gly Leu His Tyr Leu  His Ser His Gly Val  Leu His Leu 
    1190                 1195                 1200             


Asp Ile  Lys Pro Ser Asn Ile  Leu Met Val His Pro  Ala Arg Glu 
    1205                 1210                 1215             


Asp Ile  Lys Ile Cys Asp Phe  Gly Phe Ala Gln Asn  Ile Thr Pro 
    1220                 1225                 1230             


Ala Glu  Leu Gln Phe Ser Gln  Tyr Gly Ser Pro Glu  Phe Val Ser 
    1235                 1240                 1245             


Pro Glu  Ile Ile Gln Gln Asn  Pro Val Ser Glu Ala  Ser Asp Ile 
    1250                 1255                 1260             


Trp Ala  Met Gly Val Ile Ser  Tyr Leu Ser Leu Thr  Cys Ser Ser 
    1265                 1270                 1275             


Pro Phe  Ala Gly Glu Ser Asp  Arg Ala Thr Leu Leu  Asn Val Leu 
    1280                 1285                 1290             


Glu Gly  Arg Val Ser Trp Ser  Ser Pro Met Ala Ala  His Leu Ser 
    1295                 1300                 1305             


Glu Asp  Ala Lys Asp Phe Ile  Lys Ala Thr Leu Gln  Arg Ala Pro 
    1310                 1315                 1320             


Gln Ala  Arg Pro Ser Ala Ala  Gln Cys Leu Ser His  Pro Trp Phe 
    1325                 1330                 1335             


Leu Lys  Ser Met Pro Ala Glu  Glu Ala His Phe Ile  Asn Thr Lys 
    1340                 1345                 1350             


Gln Leu  Lys Phe Leu Leu Ala  Arg Ser Arg Trp Gln  Arg Ser Leu 
    1355                 1360                 1365             


Met Ser  Tyr Lys Ser Ile Leu  Val Met Arg Ser Ile  Pro Glu Leu 
    1370                 1375                 1380             


Leu Arg  Gly Pro Pro Asp Ser  Pro Ser Leu Gly Val  Ala Arg His 
    1385                 1390                 1395             


Leu Cys  Arg Asp Thr Gly Gly  Ser Ser Ser Ser Ser  Ser Ser Ser 
    1400                 1405                 1410             


Asp Asn  Glu Leu Ala Pro Phe  Ala Arg Ala Lys Ser  Leu Pro Pro 
    1415                 1420                 1425             


Ser Pro  Val Thr His Ser Pro  Leu Leu His Pro Arg  Gly Phe Leu 
    1430                 1435                 1440             


Arg Pro  Ser Ala Ser Leu Pro  Glu Glu Ala Glu Ala  Ser Glu Arg 
    1445                 1450                 1455             


Ser Thr  Glu Ala Pro Ala Pro  Pro Ala Ser Pro Glu  Gly Ala Gly 
    1460                 1465                 1470             


Pro Pro  Ala Ala Gln Gly Cys  Val Pro Arg His Ser  Val Ile Arg 
    1475                 1480                 1485             


Ser Leu  Phe Tyr His Gln Ala  Gly Glu Ser Pro Glu  His Gly Ala 
    1490                 1495                 1500             


Leu Ala  Pro Gly Ser Arg Arg  His Pro Ala Arg Arg  Arg His Leu 
    1505                 1510                 1515             


Leu Lys  Gly Gly Tyr Ile Ala  Gly Ala Leu Pro Gly  Leu Arg Glu 
    1520                 1525                 1530             


Pro Leu  Met Glu His Arg Val  Leu Glu Glu Glu Ala  Ala Arg Glu 
    1535                 1540                 1545             


Glu Gln  Ala Thr Leu Leu Ala  Lys Ala Pro Ser Phe  Glu Thr Ala 
    1550                 1555                 1560             


Leu Arg  Leu Pro Ala Ser Gly  Thr His Leu Ala Pro  Gly His Ser 
    1565                 1570                 1575             


His Ser  Leu Glu His Asp Ser  Pro Ser Thr Pro Arg  Pro Ser Ser 
    1580                 1585                 1590             


Glu Ala  Cys Gly Glu Ala Gln  Arg Leu Pro Ser Ala  Pro Ser Gly 
    1595                 1600                 1605             


Gly Ala  Pro Ile Arg Asp Met  Gly His Pro Gln Gly  Ser Lys Gln 
    1610                 1615                 1620             


Leu Pro  Ser Thr Gly Gly His  Pro Gly Thr Ala Gln  Pro Glu Arg 
    1625                 1630                 1635             


Pro Ser  Pro Asp Ser Pro Trp  Gly Gln Pro Ala Pro  Phe Cys His 
    1640                 1645                 1650             


Pro Lys  Gln Gly Ser Ala Pro  Gln Glu Gly Cys Ser  Pro His Pro 
    1655                 1660                 1665             


Ala Val  Ala Pro Cys Pro Pro  Gly Ser Phe Pro Pro  Gly Ser Cys 
    1670                 1675                 1680             


Lys Glu  Ala Pro Leu Val Pro  Ser Ser Pro Phe Leu  Gly Gln Pro 
    1685                 1690                 1695             


Gln Ala  Pro Pro Ala Pro Ala  Lys Ala Ser Pro Pro  Leu Asp Ser 
    1700                 1705                 1710             


Lys Met  Gly Pro Gly Asp Ile  Ser Leu Pro Gly Arg  Pro Lys Pro 
    1715                 1720                 1725             


Gly Pro  Cys Ser Ser Pro Gly  Ser Ala Ser Gln Ala  Ser Ser Ser 
    1730                 1735                 1740             


Gln Val  Ser Ser Leu Arg Val  Gly Ser Ser Gln Val  Gly Thr Glu 
    1745                 1750                 1755             


Pro Gly  Pro Ser Leu Asp Ala  Glu Gly Trp Thr Gln  Glu Ala Glu 
    1760                 1765                 1770             


Asp Leu  Ser Asp Ser Thr Pro  Thr Leu Gln Arg Pro  Gln Glu Gln 
    1775                 1780                 1785             


Ala Thr  Met Arg Lys Phe Ser  Leu Gly Gly Arg Gly  Gly Tyr Ala 
    1790                 1795                 1800             


Gly Val  Ala Gly Tyr Gly Thr  Phe Ala Phe Gly Gly  Asp Ala Gly 
    1805                 1810                 1815             


Gly Met  Leu Gly Gln Gly Pro  Met Trp Ala Arg Ile  Ala Trp Ala 
    1820                 1825                 1830             


Val Ser  Gln Ser Glu Glu Glu  Glu Gln Glu Glu Ala  Arg Ala Glu 
    1835                 1840                 1845             


Ser Gln  Ser Glu Glu Gln Gln  Glu Ala Arg Ala Glu  Ser Pro Leu 
    1850                 1855                 1860             


Pro Gln  Val Ser Ala Arg Pro  Val Pro Glu Val Gly  Arg Ala Pro 
    1865                 1870                 1875             


Thr Arg  Ser Ser Pro Glu Pro  Thr Pro Trp Glu Asp  Ile Gly Gln 
    1880                 1885                 1890             


Val Ser  Leu Val Gln Ile Arg  Asp Leu Ser Gly Asp  Ala Glu Ala 
    1895                 1900                 1905             


Ala Asp  Thr Ile Ser Leu Asp  Ile Ser Glu Val Asp  Pro Ala Tyr 
    1910                 1915                 1920             


Leu Asn  Leu Ser Asp Leu Tyr  Asp Ile Lys Tyr Leu  Pro Phe Glu 
    1925                 1930                 1935             


Phe Met  Ile Phe Arg Lys Val  Pro Lys Ser Ala Gln  Pro Glu Pro 
    1940                 1945                 1950             


Pro Ser  Pro Met Ala Glu Glu  Glu Leu Ala Glu Phe  Pro Glu Pro 
    1955                 1960                 1965             


Thr Trp  Pro Trp Pro Gly Glu  Leu Gly Pro His Ala  Gly Leu Glu 
    1970                 1975                 1980             


Ile Thr  Glu Glu Ser Glu Asp  Val Asp Ala Leu Leu  Ala Glu Ala 
    1985                 1990                 1995             


Ala Val  Gly Arg Lys Arg Lys  Trp Ser Ser Pro Ser  Arg Ser Leu 
    2000                 2005                 2010             


Phe His  Phe Pro Gly Arg His  Leu Pro Leu Asp Glu  Pro Ala Glu 
    2015                 2020                 2025             


Leu Gly  Leu Arg Glu Arg Val  Lys Ala Ser Val Glu  His Ile Ser 
    2030                 2035                 2040             


Arg Ile  Leu Lys Gly Arg Pro  Glu Gly Leu Glu Lys  Glu Gly Pro 
    2045                 2050                 2055             


Pro Arg  Lys Lys Pro Gly Leu  Ala Ser Phe Arg Leu  Ser Gly Leu 
    2060                 2065                 2070             


Lys Ser  Trp Asp Arg Ala Pro  Thr Phe Leu Arg Glu  Leu Ser Asp 
    2075                 2080                 2085             


Glu Thr  Val Val Leu Gly Gln  Ser Val Thr Leu Ala  Cys Gln Val 
    2090                 2095                 2100             


Ser Ala  Gln Pro Ala Ala Gln  Ala Thr Trp Ser Lys  Asp Gly Ala 
    2105                 2110                 2115             


Pro Leu  Glu Ser Ser Ser Arg  Val Leu Ile Ser Ala  Thr Leu Lys 
    2120                 2125                 2130             


Asn Phe  Gln Leu Leu Thr Ile  Leu Val Val Val Ala  Glu Asp Leu 
    2135                 2140                 2145             


Gly Val  Tyr Thr Cys Ser Val  Ser Asn Ala Leu Gly  Thr Val Thr 
    2150                 2155                 2160             


Thr Thr  Gly Val Leu Arg Lys  Ala Glu Arg Pro Ser  Ser Ser Pro 
    2165                 2170                 2175             


Cys Pro  Asp Ile Gly Glu Val  Tyr Ala Asp Gly Val  Leu Leu Val 
    2180                 2185                 2190             


Trp Lys  Pro Val Glu Ser Tyr  Gly Pro Val Thr Tyr  Ile Val Gln 
    2195                 2200                 2205             


Cys Ser  Leu Glu Gly Gly Ser  Trp Thr Thr Leu Ala  Ser Asp Ile 
    2210                 2215                 2220             


Phe Asp  Cys Cys Tyr Leu Thr  Ser Lys Leu Ser Arg  Gly Gly Thr 
    2225                 2230                 2235             


Tyr Thr  Phe Arg Thr Ala Cys  Val Ser Lys Ala Gly  Met Gly Pro 
    2240                 2245                 2250             


Tyr Ser  Ser Pro Ser Glu Gln  Val Leu Leu Gly Gly  Pro Ser His 
    2255                 2260                 2265             


Leu Ala  Ser Glu Glu Glu Ser  Gln Gly Arg Ser Ala  Gln Pro Leu 
    2270                 2275                 2280             


Pro Ser  Thr Lys Thr Phe Ala  Phe Gln Thr Gln Ile  Gln Arg Gly 
    2285                 2290                 2295             


Arg Phe  Ser Val Val Arg Gln  Cys Trp Glu Lys Ala  Ser Gly Arg 
    2300                 2305                 2310             


Ala Leu  Ala Ala Lys Ile Ile  Pro Tyr His Pro Lys  Asp Lys Thr 
    2315                 2320                 2325             


Ala Val  Leu Arg Glu Tyr Glu  Ala Leu Lys Gly Leu  Arg His Pro 
    2330                 2335                 2340             


His Leu  Ala Gln Leu His Ala  Ala Tyr Leu Ser Pro  Arg His Leu 
    2345                 2350                 2355             


Val Leu  Ile Leu Glu Leu Cys  Ser Gly Pro Glu Leu  Leu Pro Cys 
    2360                 2365                 2370             


Leu Ala  Glu Arg Ala Ser Tyr  Ser Glu Ser Glu Val  Lys Asp Tyr 
    2375                 2380                 2385             


Leu Trp  Gln Met Leu Ser Ala  Thr Gln Tyr Leu His  Asn Gln His 
    2390                 2395                 2400             


Ile Leu  His Leu Asp Leu Arg  Ser Glu Asn Met Ile  Ile Thr Glu 
    2405                 2410                 2415             


Tyr Asn  Leu Leu Lys Val Val  Asp Leu Gly Asn Ala  Gln Ser Leu 
    2420                 2425                 2430             


Ser Gln  Glu Lys Val Leu Pro  Ser Asp Lys Phe Lys  Asp Tyr Leu 
    2435                 2440                 2445             


Glu Thr  Met Glu Leu Leu Glu  Gly Gln Gly Ala Val  Pro Gln Thr 
    2450                 2455                 2460             


Asp Ile  Trp Ala Ile Gly Val  Thr Ala Phe Ile Met  Leu Ser Ala 
    2465                 2470                 2475             


Glu Tyr  Pro Val Ser Ser Glu  Gly Ala Arg Asp Leu  Gln Arg Gly 
    2480                 2485                 2490             


Leu Arg  Lys Gly Leu Val Arg  Leu Ser Arg Cys Tyr  Ala Gly Leu 
    2495                 2500                 2505             


Ser Gly  Gly Ala Val Ala Phe  Leu Arg Ser Thr Leu  Cys Ala Gln 
    2510                 2515                 2520             


Pro Trp  Gly Arg Pro Cys Ala  Ser Ser Cys Leu Gln  Cys Pro Trp 
    2525                 2530                 2535             


Leu Thr  Glu Glu Gly Pro Ala  Cys Ser Arg Pro Ala  Pro Val Thr 
    2540                 2545                 2550             


Phe Pro  Thr Ala Arg Leu Arg  Val Phe Val Arg Asn  Arg Glu Lys 
    2555                 2560                 2565             


Arg Arg  Ala Leu Leu Tyr Lys  Arg His Asn Leu Ala  Gln Val Arg 
    2570                 2575                 2580             


<210> 7832
<211> 582
<212> PRT
<213> Homo sapiens

<400> 7832
Met Glu Lys Ala Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys 
1               5                   10                  15      


His Leu Lys Thr Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser 
            20                  25                  30          


Glu Ser His Leu Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr 
        35                  40                  45              


Glu Leu Glu Ala Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val 
    50                  55                  60                  


Glu Leu Leu Leu Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe 
65                  70                  75                  80  


Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ile Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Glu His Leu Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn 
        115                 120                 125             


Leu Ser Ser Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn 
    130                 135                 140                 


Thr Asn Leu Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn 
                165                 170                 175     


Arg Phe Ser Gln Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln 
            180                 185                 190         


Ile His Lys Arg Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys 
        195                 200                 205             


Ser Leu Glu Thr Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn 
    210                 215                 220                 


Lys Asn Glu Ala Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val 
225                 230                 235                 240 


Ala Leu Lys Lys Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe 
                245                 250                 255     


Thr Gly Ala Ile Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala 
            260                 265                 270         


Lys Leu Ser Glu Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr 
        275                 280                 285             


Glu Lys Ile Val Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr 
    290                 295                 300                 


Met Lys Lys Gln Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu 
305                 310                 315                 320 


Asp His Gly Lys Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser 
                325                 330                 335     


Ile Glu Tyr Glu Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys 
            340                 345                 350         


Thr Thr Leu Ala Ala Leu Lys Asp Glu Val Val Ser Val Glu Asn Glu 
        355                 360                 365             


Leu Ser Glu Leu Gln Glu Val Glu Lys Lys Gln Lys Thr Leu Ile Glu 
    370                 375                 380                 


Met Tyr Lys Thr Gln Val Gln Lys Leu Gln Glu Ala Ala Glu Ile Val 
385                 390                 395                 400 


Lys Ser Arg Cys Glu Asn Leu Leu His Lys Asn Asn Gln Ile Thr Lys 
                405                 410                 415     


Thr Lys Asn Lys Asn Val Glu Lys Met Arg Gly Gln Met Glu Ser His 
            420                 425                 430         


Leu Lys Glu Leu Glu Arg Val Cys Asp Ser Leu Thr Ala Ala Glu Arg 
        435                 440                 445             


Arg Leu His Glu Cys Gln Val Asp Gly Asn His Asn Leu Leu Thr Lys 
    450                 455                 460                 


Leu Ser Leu Glu Glu Glu Asn Cys Leu Ile Gln Leu Lys Cys Glu Asn 
465                 470                 475                 480 


Leu Gln Gln Lys Leu Glu Gln Met Asp Ala Glu Asn Lys Glu Leu Glu 
                485                 490                 495     


Lys Lys Leu Ala Asn Gln Glu Glu Cys Leu Lys His Ser Asn Leu Lys 
            500                 505                 510         


Phe Lys Glu Lys Ser Ala Glu Tyr Thr Ala Leu Ala Arg Gln Leu Glu 
        515                 520                 525             


Ala Ala Leu Glu Glu Gly Arg Gln Lys Val Ala Glu Glu Ile Glu Lys 
    530                 535                 540                 


Met Ser Ser Arg Glu Ser Ala Leu Gln Ile Lys Ile Leu Asp Leu Glu 
545                 550                 555                 560 


Thr Glu Leu Arg Lys Lys Asn Glu Glu Gln Asn Gln Leu Val Cys Lys 
                565                 570                 575     


Met Asn Ser Thr Asn Gly 
            580         


<210> 7833
<211> 127
<212> PRT
<213> Homo sapiens

<400> 7833
Met Val Ser Ser Gly Arg Arg Trp Leu Arg Glu Gln Gln His Arg Arg 
1               5                   10                  15      


Trp Arg Leu His Cys Leu Lys Leu Gln Pro Leu Ser Pro Val Pro Ser 
            20                  25                  30          


Asp Ile Glu Ile Ser Arg Gly Gln Thr Pro Lys Ala Val Asp Val Leu 
        35                  40                  45              


Ala Lys Glu Ile Gly Leu Leu Ala Asp Glu Ile Glu Ile Tyr Gly Lys 
    50                  55                  60                  


Ser Lys Ala Lys Val Arg Leu Ser Val Leu Glu Arg Leu Lys Asp Gln 
65                  70                  75                  80  


Ala Asp Gly Lys Tyr Val Leu Val Ala Gly Ile Thr Pro Thr Pro Leu 
                85                  90                  95      


Gly Glu Gly Lys Ser Thr Val Thr Ile Gly Leu Val Gln Ala Leu Thr 
            100                 105                 110         


Ala His Leu Asn Val Asn Ser Phe Ala Cys Leu Arg Gln Pro Ser 
        115                 120                 125         


<210> 7834
<211> 642
<212> PRT
<213> Homo sapiens

<400> 7834
Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr Gly Ser Val Glu 
1               5                   10                  15      


Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln Glu Ile Ala Arg 
            20                  25                  30          


Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg Val Phe Lys Pro 
        35                  40                  45              


Met Ala Asp Ala Ala Val Lys Ile Val Glu Lys Asn Gly Phe Ser Asp 
    50                  55                  60                  


Lys Ile Lys Val Ile Asn Lys His Ser Thr Glu Val Thr Val Gly Pro 
65                  70                  75                  80  


Glu Gly Asp Met Pro Cys Arg Ala Asn Ile Leu Val Thr Glu Leu Phe 
                85                  90                  95      


Asp Thr Glu Leu Ile Gly Glu Gly Ala Leu Pro Ser Tyr Glu His Ala 
            100                 105                 110         


His Arg His Leu Val Glu Glu Asn Cys Glu Ala Val Pro His Arg Ala 
        115                 120                 125             


Thr Val Tyr Ala Gln Leu Val Glu Ser Gly Arg Met Trp Ser Trp Asn 
    130                 135                 140                 


Lys Leu Phe Pro Ile His Val Gln Thr Ser Leu Gly Glu Gln Val Ile 
145                 150                 155                 160 


Val Pro Pro Val Asp Val Glu Ser Cys Pro Gly Ala Pro Ser Val Cys 
                165                 170                 175     


Asp Ile Gln Leu Asn Gln Val Ser Pro Ala Asp Phe Thr Val Leu Ser 
            180                 185                 190         


Asp Val Leu Pro Met Phe Ser Ile Asp Phe Ser Lys Gln Val Ser Ser 
        195                 200                 205             


Ser Ala Ala Cys His Ser Arg Arg Phe Glu Pro Leu Thr Ser Gly Arg 
    210                 215                 220                 


Ala Gln Val Val Leu Ser Trp Trp Asp Ile Glu Met Asp Pro Glu Gly 
225                 230                 235                 240 


Lys Ile Lys Cys Thr Met Ala Pro Phe Trp Ala His Ser Asp Pro Glu 
                245                 250                 255     


Glu Met Gln Trp Arg Asp His Trp Met Gln Cys Val Tyr Phe Leu Pro 
            260                 265                 270         


Gln Glu Glu Pro Val Val Gln Gly Ser Ala Leu Tyr Leu Val Ala His 
        275                 280                 285             


His Asp Asp Tyr Cys Val Trp Tyr Ser Leu Gln Arg Thr Ser Pro Glu 
    290                 295                 300                 


Lys Asn Glu Arg Val Arg Gln Met Arg Pro Val Cys Asp Cys Gln Ala 
305                 310                 315                 320 


His Leu Leu Trp Asn Arg Pro Arg Phe Gly Glu Ile Asn Asp Gln Asp 
                325                 330                 335     


Arg Thr Asp Arg Tyr Val Gln Ala Leu Arg Thr Val Leu Lys Pro Asp 
            340                 345                 350         


Ser Val Cys Leu Cys Val Ser Asp Gly Ser Leu Leu Ser Val Leu Ala 
        355                 360                 365             


His His Leu Gly Val Glu Gln Val Phe Thr Val Glu Ser Ser Ala Ala 
    370                 375                 380                 


Ser His Lys Leu Leu Arg Lys Ile Phe Lys Ala Asn His Leu Glu Asp 
385                 390                 395                 400 


Lys Ile Asn Ile Ile Glu Lys Arg Pro Glu Leu Leu Thr Asn Glu Asp 
                405                 410                 415     


Leu Gln Gly Arg Lys Val Ser Leu Leu Leu Gly Glu Pro Phe Phe Thr 
            420                 425                 430         


Thr Ser Leu Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val Arg Thr 
        435                 440                 445             


Ala Val Asp Gln His Leu Gly Pro Gly Ala Met Val Met Pro Gln Ala 
    450                 455                 460                 


Ala Ser Leu His Ala Val Val Val Glu Phe Arg Asp Leu Trp Arg Ile 
465                 470                 475                 480 


Arg Ser Pro Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile Met Asp 
                485                 490                 495     


Asp Met Ile Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu Ala Glu 
            500                 505                 510         


Pro His Pro Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu Pro Trp 
        515                 520                 525             


Gln Ile Leu Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln Pro Leu 
    530                 535                 540                 


Cys Ala Glu Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser His Ala 
545                 550                 555                 560 


Ala Val Leu Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr Leu Ser 
                565                 570                 575     


Thr Gly Leu Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys Trp Asn 
            580                 585                 590         


Pro His Cys Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro Asp Pro 
        595                 600                 605             


Arg Ala Leu Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val Glu Phe 
    610                 615                 620                 


His Pro Asp Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala Asp Thr 
625                 630                 635                 640 


Pro Asp 
        


<210> 7835
<211> 99
<212> PRT
<213> Homo sapiens

<400> 7835
Met Val Val Lys Leu Leu Ser Asn Lys Arg Ser Gln Ala Val Gly Ile 
1               5                   10                  15      


Leu Met Ser Ser Leu His Leu Asp Met Lys Asp Ile Gln His Ala Val 
            20                  25                  30          


Val Asn Leu Asp Asn Ser Val Val Asp Leu Glu Thr Leu Gln Ala Leu 
        35                  40                  45              


Tyr Glu Asn Arg Ala Gln Ser Asp Glu Leu Glu Lys Ile Glu Lys His 
    50                  55                  60                  


Gly Arg Ser Ser Lys Asp Lys Glu Asn Ala Lys Ser Leu Asp Lys Pro 
65                  70                  75                  80  


Glu Gln Phe Leu Tyr Glu Leu Ser Leu Ile Pro Asn Phe Ser Glu Arg 
                85                  90                  95      


Val Phe Cys 
            


<210> 7836
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7836
Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu 
1               5                   10                  15      


Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser 
            20                  25                  30          


Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His 
        35                  40                  45              


Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro 
    50                  55                  60                  


Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn 
65                  70                  75                  80  


Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val 
                85                  90                  95      


Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr 
            100                 105                 110         


Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys 
        115                 120                 125             


Pro 
    


<210> 7837
<211> 150
<212> PRT
<213> Homo sapiens

<400> 7837
Met Asn Leu Ala Glu Ile Cys Asp Asn Ala Lys Lys Gly Arg Glu Tyr 
1               5                   10                  15      


Ala Leu Leu Gly Asn Tyr Asp Ser Ser Met Val Tyr Tyr Gln Gly Val 
            20                  25                  30          


Met Gln Gln Ile Gln Arg His Cys Gln Ser Val Arg Asp Pro Ala Ile 
        35                  40                  45              


Lys Gly Lys Trp Gln Gln Val Arg Gln Glu Leu Leu Glu Glu Tyr Glu 
    50                  55                  60                  


Gln Val Lys Ser Ile Val Ser Thr Leu Glu Ser Phe Lys Ile Asp Lys 
65                  70                  75                  80  


Pro Pro Asp Phe Pro Val Ser Cys Gln Asp Glu Pro Phe Arg Asp Pro 
                85                  90                  95      


Ala Val Trp Pro Pro Pro Val Pro Ala Glu His Arg Ala Pro Pro Gln 
            100                 105                 110         


Ile Arg Arg Pro Asn Arg Glu Val Arg Pro Leu Arg Lys Glu Met Ala 
        115                 120                 125             


Gly Val Gly Ala Arg Gly Pro Val Gly Arg Ala His Pro Ile Ser Lys 
    130                 135                 140                 


Ser Glu Lys Pro Ser Thr 
145                 150 


<210> 7838
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7838
Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp 
                165 


<210> 7839
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7839
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 7840
<211> 2002
<212> PRT
<213> Homo sapiens

<400> 7840
Met Glu Glu Arg Lys His Glu Thr Met Asn Pro Ala His Val Leu Phe 
1               5                   10                  15      


Asp Arg Phe Val Gln Ala Thr Thr Cys Lys Gly Thr Leu Lys Ala Phe 
            20                  25                  30          


Gln Glu Leu Cys Asp His Leu Glu Leu Lys Pro Lys Asp Tyr Arg Ser 
        35                  40                  45              


Phe Tyr His Lys Leu Lys Ser Lys Leu Asn Tyr Trp Lys Ala Lys Ala 
    50                  55                  60                  


Leu Trp Ala Lys Leu Asp Lys Arg Gly Ser His Lys Asp Tyr Lys Lys 
65                  70                  75                  80  


Gly Lys Ala Cys Thr Asn Thr Lys Cys Leu Ile Ile Gly Ala Gly Pro 
                85                  90                  95      


Cys Gly Leu Arg Thr Ala Ile Asp Leu Ser Leu Leu Gly Ala Lys Val 
            100                 105                 110         


Val Val Ile Glu Lys Arg Asp Ala Phe Ser Arg Asn Asn Val Leu His 
        115                 120                 125             


Leu Trp Pro Phe Thr Ile His Asp Leu Arg Gly Leu Gly Ala Lys Lys 
    130                 135                 140                 


Phe Tyr Gly Lys Phe Cys Ala Gly Ala Ile Asp His Ile Ser Ile Arg 
145                 150                 155                 160 


Gln Leu Gln Leu Ile Leu Leu Lys Val Ala Leu Ile Leu Gly Ile Glu 
                165                 170                 175     


Ile His Val Asn Val Glu Phe Gln Gly Leu Ile Gln Pro Pro Glu Asp 
            180                 185                 190         


Gln Glu Asn Glu Arg Ile Gly Trp Arg Ala Leu Val His Pro Lys Thr 
        195                 200                 205             


His Pro Val Ser Glu Tyr Glu Phe Glu Val Ile Ile Gly Gly Asp Gly 
    210                 215                 220                 


Arg Arg Asn Thr Leu Glu Gly Phe Arg Arg Lys Glu Phe Arg Gly Lys 
225                 230                 235                 240 


Leu Ala Ile Ala Ile Thr Ala Asn Phe Ile Asn Arg Asn Thr Thr Ala 
                245                 250                 255     


Glu Ala Lys Val Glu Glu Ile Ser Gly Val Ala Phe Ile Phe Asn Gln 
            260                 265                 270         


Lys Phe Phe Gln Glu Leu Arg Glu Ala Thr Gly Ile Asp Leu Glu Asn 
        275                 280                 285             


Ile Val Tyr Tyr Lys Asp Asp Thr His Tyr Phe Val Met Thr Ala Lys 
    290                 295                 300                 


Lys Gln Ser Leu Leu Asp Lys Gly Val Ile Leu His Asp Tyr Ala Asp 
305                 310                 315                 320 


Thr Glu Leu Leu Leu Ser Arg Glu Asn Val Asp Gln Glu Ala Leu Leu 
                325                 330                 335     


Ser Tyr Ala Arg Glu Ala Ala Asp Phe Ser Thr Gln Gln Gln Leu Pro 
            340                 345                 350         


Ser Leu Asp Phe Ala Ile Asn His Tyr Gly Gln Pro Asp Val Ala Met 
        355                 360                 365             


Phe Asp Phe Thr Cys Met Tyr Ala Ser Glu Asn Ala Ala Leu Val Arg 
    370                 375                 380                 


Glu Gln Asn Gly His Gln Leu Leu Val Ala Leu Val Gly Asp Ser Leu 
385                 390                 395                 400 


Leu Glu Pro Phe Trp Pro Met Gly Thr Gly Ile Ala Arg Gly Phe Leu 
                405                 410                 415     


Ala Ala Met Asp Ser Ala Trp Met Val Arg Ser Trp Ser Leu Gly Thr 
            420                 425                 430         


Ser Pro Leu Glu Val Leu Ala Glu Arg Glu Ser Ile Tyr Arg Leu Leu 
        435                 440                 445             


Pro Gln Thr Thr Pro Glu Asn Val Ser Lys Asn Phe Ser Gln Tyr Ser 
    450                 455                 460                 


Ile Asp Pro Val Thr Arg Tyr Pro Asn Ile Asn Val Asn Phe Leu Arg 
465                 470                 475                 480 


Pro Ser Gln Val Arg His Leu Tyr Asp Thr Gly Glu Thr Lys Asp Ile 
                485                 490                 495     


His Leu Glu Met Glu Ser Leu Val Asn Ser Arg Thr Thr Pro Lys Leu 
            500                 505                 510         


Thr Arg Asn Glu Ser Val Ala Arg Ser Ser Lys Leu Leu Gly Trp Cys 
        515                 520                 525             


Gln Arg Gln Thr Asp Gly Tyr Ala Gly Val Asn Val Thr Asp Leu Thr 
    530                 535                 540                 


Met Ser Trp Lys Ser Gly Leu Ala Leu Cys Ala Ile Ile His Arg Tyr 
545                 550                 555                 560 


Arg Pro Asp Leu Ile Asp Phe Asp Ser Leu Asp Glu Gln Asn Val Glu 
                565                 570                 575     


Lys Asn Asn Gln Leu Ala Phe Asp Ile Ala Glu Lys Glu Leu Gly Ile 
            580                 585                 590         


Ser Pro Ile Met Thr Gly Lys Glu Met Ala Ser Val Gly Glu Pro Asp 
        595                 600                 605             


Lys Leu Ser Met Val Met Tyr Leu Thr Gln Phe Tyr Glu Met Phe Lys 
    610                 615                 620                 


Asp Ser Leu Pro Ser Ser Asp Thr Leu Asp Leu Asn Ala Glu Glu Lys 
625                 630                 635                 640 


Ala Val Leu Ile Ala Ser Thr Arg Ser Pro Ile Ser Phe Leu Ser Lys 
                645                 650                 655     


Leu Gly Gln Thr Ile Ser Arg Lys Arg Ser Pro Lys Asp Lys Lys Glu 
            660                 665                 670         


Lys Asp Leu Asp Gly Ala Gly Lys Arg Arg Lys Thr Ser Gln Ser Glu 
        675                 680                 685             


Glu Glu Glu Ala Pro Arg Gly His Arg Gly Glu Arg Pro Thr Leu Val 
    690                 695                 700                 


Ser Thr Leu Thr Asp Arg Arg Met Asp Val Ala Val Gly Asn Gln Asn 
705                 710                 715                 720 


Lys Val Lys Tyr Met Ala Thr Gln Leu Leu Ala Lys Phe Glu Glu Asn 
                725                 730                 735     


Ala Pro Ala Gln Ser Ile Gly Ile Arg Arg Gln Gly Ser Met Lys Lys 
            740                 745                 750         


Glu Phe Pro Gln Asn Leu Gly Gly Ser Asp Thr Cys Tyr Phe Cys Gln 
        755                 760                 765             


Lys Arg Val Tyr Val Met Glu Arg Leu Ser Ala Glu Gly Lys Phe Phe 
    770                 775                 780                 


His Arg Ser Cys Phe Lys Cys Glu Tyr Cys Ala Thr Thr Leu Arg Leu 
785                 790                 795                 800 


Ser Ala Tyr Ala Tyr Asp Ile Glu Asp Gly Lys Phe Tyr Cys Lys Pro 
                805                 810                 815     


His Tyr Cys Tyr Arg Leu Ser Gly Tyr Ala Gln Arg Lys Arg Pro Ala 
            820                 825                 830         


Val Ala Pro Leu Ser Gly Lys Glu Ala Lys Gly Pro Leu Gln Asp Gly 
        835                 840                 845             


Ala Thr Thr Asp Ala Asn Gly Arg Ala Asn Ala Val Ala Ser Ser Thr 
    850                 855                 860                 


Glu Arg Thr Pro Gly Ser Gly Val Asn Gly Leu Glu Glu Pro Ser Ile 
865                 870                 875                 880 


Ala Lys Arg Leu Arg Gly Thr Pro Glu Arg Ile Glu Leu Glu Asn Tyr 
                885                 890                 895     


Arg Leu Ser Leu Arg Gln Ala Glu Ala Leu Gln Glu Val Pro Glu Glu 
            900                 905                 910         


Thr Gln Ala Glu His Asn Leu Ser Ser Val Leu Asp Thr Gly Ala Glu 
        915                 920                 925             


Glu Asp Val Ala Ser Ser Ser Ser Glu Ser Glu Met Glu Glu Glu Gly 
    930                 935                 940                 


Glu Glu Glu Glu Glu Glu Pro Arg Leu Pro Pro Ser Asp Leu Gly Gly 
945                 950                 955                 960 


Val Pro Trp Lys Glu Ala Val Arg Ile His Ala Leu Leu Lys Gly Lys 
                965                 970                 975     


Ser Glu Glu Glu Leu Glu Ala Ser Lys Ser Phe Gly Pro Gly Asn Glu 
            980                 985                 990         


Glu Glu Glu Glu Glu Glu Glu Glu  Tyr Glu Glu Glu Glu  Glu Glu Asp 
        995                 1000                 1005             


Tyr Asp  Glu Glu Glu Glu Glu  Ser Ser Glu Ala Gly  Asn Gln Arg 
    1010                 1015                 1020             


Leu Gln  Gln Val Met His Ala  Ala Asp Pro Leu Glu  Ile Gln Ala 
    1025                 1030                 1035             


Asp Val  His Trp Thr His Ile  Arg Glu Arg Glu Glu  Glu Glu Arg 
    1040                 1045                 1050             


Met Ala  Pro Ala Ser Glu Ser  Ser Ala Ser Gly Ala  Pro Leu Asp 
    1055                 1060                 1065             


Glu Asn  Asp Leu Glu Glu Asp  Val Asp Ser Glu Pro  Ala Glu Ile 
    1070                 1075                 1080             


Glu Gly  Glu Ala Ala Glu Asp  Gly Asp Pro Gly Asp  Thr Gly Ala 
    1085                 1090                 1095             


Glu Leu  Asp Asp Asp Gln His  Trp Ser Asp Ser Pro  Ser Asp Ala 
    1100                 1105                 1110             


Asp Arg  Glu Leu Arg Leu Pro  Cys Pro Ala Glu Gly  Glu Ala Glu 
    1115                 1120                 1125             


Leu Glu  Leu Arg Val Ser Glu  Asp Glu Glu Lys Leu  Pro Ala Ser 
    1130                 1135                 1140             


Pro Lys  His Gln Glu Arg Gly  Pro Ser Gln Ala Thr  Ser Pro Ile 
    1145                 1150                 1155             


Arg Ser  Pro Gln Glu Ser Ala  Leu Leu Phe Ile Pro  Val His Ser 
    1160                 1165                 1170             


Pro Ser  Thr Glu Gly Pro Gln  Leu Pro Pro Val Pro  Ala Ala Thr 
    1175                 1180                 1185             


Gln Glu  Lys Ser Pro Glu Glu  Arg Leu Phe Pro Glu  Pro Leu Leu 
    1190                 1195                 1200             


Pro Lys  Glu Lys Pro Lys Ala  Asp Ala Pro Ser Asp  Leu Lys Ala 
    1205                 1210                 1215             


Val His  Ser Pro Ile Arg Ser  Gln Pro Val Thr Leu  Pro Glu Ala 
    1220                 1225                 1230             


Arg Thr  Pro Val Ser Pro Gly  Ser Pro Gln Pro Gln  Pro Pro Val 
    1235                 1240                 1245             


Ala Ala  Ser Thr Pro Pro Pro  Ser Pro Leu Pro Ile  Cys Ser Gln 
    1250                 1255                 1260             


Pro Gln  Pro Ser Thr Glu Ala  Thr Val Pro Ser Pro  Thr Gln Ser 
    1265                 1270                 1275             


Pro Ile  Arg Phe Gln Pro Ala  Pro Ala Lys Thr Ser  Thr Pro Leu 
    1280                 1285                 1290             


Ala Pro  Leu Pro Val Gln Ser  Gln Ser Asp Thr Lys  Asp Arg Leu 
    1295                 1300                 1305             


Gly Ser  Pro Leu Ala Val Asp  Glu Ala Leu Arg Arg  Ser Asp Leu 
    1310                 1315                 1320             


Val Glu  Glu Phe Trp Met Lys  Ser Ala Glu Ile Arg  Arg Ser Leu 
    1325                 1330                 1335             


Gly Leu  Thr Pro Val Asp Arg  Ser Lys Gly Pro Glu  Pro Ser Phe 
    1340                 1345                 1350             


Pro Thr  Pro Ala Phe Arg Pro  Val Ser Leu Lys Ser  Tyr Ser Val 
    1355                 1360                 1365             


Glu Lys  Ser Pro Gln Asp Glu  Gly Leu His Leu Leu  Lys Pro Leu 
    1370                 1375                 1380             


Ser Ile  Pro Lys Arg Leu Gly  Leu Pro Lys Pro Glu  Gly Glu Pro 
    1385                 1390                 1395             


Leu Ser  Leu Pro Thr Pro Arg  Ser Pro Ser Asp Arg  Glu Leu Arg 
    1400                 1405                 1410             


Ser Ala  Gln Glu Glu Arg Arg  Glu Leu Ser Ser Ser  Ser Gly Leu 
    1415                 1420                 1425             


Gly Leu  His Gly Ser Ser Ser  Asn Met Lys Thr Leu  Gly Ser Gln 
    1430                 1435                 1440             


Ser Phe  Asn Thr Ser Asp Ser  Ala Met Leu Thr Pro  Pro Ser Ser 
    1445                 1450                 1455             


Pro Pro  Pro Pro Pro Pro Pro  Gly Glu Glu Pro Ala  Thr Leu Arg 
    1460                 1465                 1470             


Arg Lys  Leu Arg Glu Ala Glu  Pro Asn Ala Ser Val  Val Pro Pro 
    1475                 1480                 1485             


Pro Leu  Pro Ala Thr Trp Met  Arg Pro Pro Arg Glu  Pro Ala Gln 
    1490                 1495                 1500             


Pro Pro  Arg Glu Glu Val Arg  Lys Ser Phe Val Glu  Ser Val Glu 
    1505                 1510                 1515             


Glu Ile  Pro Phe Ala Asp Asp  Val Glu Asp Thr Tyr  Asp Asp Lys 
    1520                 1525                 1530             


Thr Glu  Asp Ser Ser Leu Gln  Glu Lys Phe Phe Thr  Pro Pro Ser 
    1535                 1540                 1545             


Cys Trp  Pro Arg Pro Glu Lys  Pro Arg His Pro Pro  Leu Ala Lys 
    1550                 1555                 1560             


Glu Asn  Gly Arg Leu Pro Ala  Leu Glu Gly Thr Leu  Gln Pro Gln 
    1565                 1570                 1575             


Lys Arg  Gly Leu Pro Leu Val  Ser Ala Glu Ala Lys  Glu Leu Ala 
    1580                 1585                 1590             


Glu Glu  Arg Met Arg Ala Arg  Glu Lys Ser Val Lys  Ser Gln Ala 
    1595                 1600                 1605             


Leu Arg  Asp Ala Met Ala Arg  Gln Leu Ser Arg Met  Gln Gln Met 
    1610                 1615                 1620             


Glu Leu  Ala Ser Gly Ala Pro  Arg Pro Arg Lys Ala  Ser Ser Ala 
    1625                 1630                 1635             


Pro Ser  Gln Gly Lys Glu Arg  Arg Pro Asp Ser Pro  Thr Arg Pro 
    1640                 1645                 1650             


Thr Leu  Arg Gly Ser Glu Glu  Pro Thr Leu Lys His  Glu Ala Thr 
    1655                 1660                 1665             


Ser Glu  Glu Val Leu Ser Pro  Pro Ser Asp Ser Gly  Gly Pro Asp 
    1670                 1675                 1680             


Gly Ser  Phe Thr Ser Ser Glu  Gly Ser Ser Gly Lys  Ser Lys Lys 
    1685                 1690                 1695             


Arg Ser  Ser Leu Phe Ser Pro  Arg Arg Asn Lys Lys  Glu Lys Lys 
    1700                 1705                 1710             


Ser Lys  Gly Glu Gly Arg Pro  Pro Glu Lys Pro Ser  Ser Asn Leu 
    1715                 1720                 1725             


Leu Glu  Glu Ala Ala Ala Lys  Pro Lys Ser Leu Trp  Lys Ser Val 
    1730                 1735                 1740             


Phe Ser  Gly Tyr Lys Lys Asp  Lys Lys Lys Lys Ala  Asp Asp Lys 
    1745                 1750                 1755             


Ser Cys  Pro Ser Thr Pro Ser  Ser Gly Ala Thr Val  Asp Ser Gly 
    1760                 1765                 1770             


Lys His  Arg Val Leu Pro Val  Val Arg Ala Glu Leu  Gln Leu Arg 
    1775                 1780                 1785             


Arg Gln  Leu Ser Phe Ser Glu  Asp Ser Asp Leu Ser  Ser Asp Asp 
    1790                 1795                 1800             


Val Leu  Glu Lys Ser Ser Gln  Lys Ser Arg Arg Glu  Pro Arg Thr 
    1805                 1810                 1815             


Tyr Thr  Glu Glu Glu Leu Asn  Ala Lys Leu Thr Arg  Arg Val Gln 
    1820                 1825                 1830             


Lys Ala  Ala Arg Arg Gln Ala  Lys Gln Glu Glu Leu  Lys Arg Leu 
    1835                 1840                 1845             


His Arg  Ala Gln Ile Ile Gln  Arg Gln Leu Gln Gln  Val Glu Glu 
    1850                 1855                 1860             


Arg Gln  Arg Arg Leu Glu Glu  Arg Gly Val Ala Val  Glu Lys Ala 
    1865                 1870                 1875             


Leu Arg  Gly Glu Ala Gly Met  Gly Lys Lys Asp Asp  Pro Lys Leu 
    1880                 1885                 1890             


Met Gln  Glu Trp Phe Lys Leu  Val Gln Glu Lys Asn  Ala Met Val 
    1895                 1900                 1905             


Arg Tyr  Glu Ser Glu Leu Met  Ile Phe Ala Arg Glu  Leu Glu Leu 
    1910                 1915                 1920             


Glu Asp  Arg Gln Ser Arg Leu  Gln Gln Glu Leu Arg  Glu Arg Met 
    1925                 1930                 1935             


Ala Val  Glu Asp His Leu Lys  Thr Glu Glu Glu Leu  Ser Glu Glu 
    1940                 1945                 1950             


Lys Gln  Ile Leu Asn Glu Met  Leu Glu Val Val Glu  Gln Arg Asp 
    1955                 1960                 1965             


Ser Leu  Val Ala Leu Leu Glu  Glu Gln Arg Leu Arg  Glu Arg Glu 
    1970                 1975                 1980             


Glu Asp  Lys Asp Leu Glu Ala  Ala Met Leu Ser Lys  Gly Phe Ser 
    1985                 1990                 1995             


Leu Asn  Trp Ser 
    2000         


<210> 7841
<211> 179
<212> PRT
<213> Homo sapiens

<400> 7841
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Val Glu Ala Cys Tyr Asn Cys Gly 
65                  70                  75                  80  


Arg Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg 
                85                  90                  95      


Glu Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp 
            100                 105                 110         


Cys Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly 
        115                 120                 125             


His Ile Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu 
    130                 135                 140                 


Thr Gly His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys 
145                 150                 155                 160 


Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu 
                165                 170                 175     


Ala Thr Ala 
            


<210> 7842
<211> 379
<212> PRT
<213> Homo sapiens

<400> 7842
Ala Arg Ala Val Pro Val Gly Ser Gly Leu Arg Gly Leu Gln Arg Thr 
1               5                   10                  15      


Leu Pro Leu Val Val Ile Leu Gly Ala Thr Gly Thr Gly Lys Ser Thr 
            20                  25                  30          


Leu Ala Leu Gln Leu Gly Gln Arg Leu Gly Gly Glu Ile Val Ser Ala 
        35                  40                  45              


Asp Ser Met Gln Pro Gln Glu Met Gly Thr Glu Lys Val Ile Asp Arg 
    50                  55                  60                  


Lys Val Glu Leu Glu Lys Glu Asp Gly Leu Val Leu His Lys Arg Leu 
65                  70                  75                  80  


Ser Gln Val Asp Pro Glu Met Ala Ala Lys Leu His Pro His Asp Lys 
                85                  90                  95      


Arg Lys Val Ala Arg Ser Leu Gln Val Phe Glu Glu Thr Gly Ile Ser 
            100                 105                 110         


His Ser Glu Phe Leu His Arg Gln His Thr Glu Glu Gly Gly Gly Pro 
        115                 120                 125             


Leu Gly Gly Pro Leu Lys Phe Ser Asn Pro Cys Ile Leu Trp Leu His 
    130                 135                 140                 


Ala Asp Gln Ala Asp Glu Arg Leu Asp Lys Arg Val Asp Asp Met Leu 
145                 150                 155                 160 


Ala Ala Gly Leu Leu Glu Glu Leu Arg Asp Phe His Arg Arg Tyr Asn 
                165                 170                 175     


Gln Lys Asn Val Ser Glu Asn Ser Gln Asp Tyr Gln His Gly Ile Phe 
            180                 185                 190         


Gln Ser Ile Gly Phe Lys Glu Phe His Glu Tyr Leu Ile Thr Glu Gly 
        195                 200                 205             


Lys Cys Thr Leu Glu Thr Ser Asn Gln Leu Leu Lys Lys Gly Ile Glu 
    210                 215                 220                 


Ala Leu Lys Gln Val Thr Lys Arg Tyr Ala Arg Lys Gln Asn Arg Trp 
225                 230                 235                 240 


Val Lys Asn Arg Phe Leu Ser Arg Pro Gly Pro Ile Val Pro Pro Val 
                245                 250                 255     


Tyr Gly Leu Glu Val Ser Asp Val Ser Lys Trp Glu Glu Ser Val Leu 
            260                 265                 270         


Glu Pro Ala Leu Glu Ile Val Gln Ser Phe Ile Gln Gly His Lys Pro 
        275                 280                 285             


Thr Ala Thr Pro Ile Lys Met Pro Tyr Asn Glu Ala Glu Asn Lys Arg 
    290                 295                 300                 


Ser Tyr His Leu Cys Asp Leu Cys Asp Arg Ile Ile Ile Gly Asp Arg 
305                 310                 315                 320 


Glu Trp Ala Ala His Ile Lys Ser Lys Ser His Leu Asn Gln Leu Lys 
                325                 330                 335     


Lys Arg Arg Arg Leu Asp Ser Asp Ala Val Asn Thr Ile Glu Ser Gln 
            340                 345                 350         


Ser Val Ser Pro Asp His Asn Lys Glu Pro Lys Glu Lys Gly Ser Pro 
        355                 360                 365             


Gly Gln Asn Asp Gln Glu Leu Lys Cys Ser Val 
    370                 375                 


<210> 7843
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7843
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7844
<211> 271
<212> PRT
<213> Homo sapiens

<400> 7844
Met Asn Leu Glu Lys Leu Ser Lys Pro Glu Leu Leu Thr Leu Phe Ser 
1               5                   10                  15      


Ile Leu Glu Gly Glu Leu Glu Ala Arg Asp Leu Val Ile Glu Ala Leu 
            20                  25                  30          


Lys Ala Gln His Arg Asp Thr Phe Ile Glu Glu Arg Tyr Gly Lys Tyr 
        35                  40                  45              


Asn Ile Ser Asp Pro Leu Met Ala Leu Gln Arg Asp Phe Glu Thr Leu 
    50                  55                  60                  


Lys Glu Lys Asn Asp Gly Glu Lys Gln Pro Val Cys Thr Asn Pro Leu 
65                  70                  75                  80  


Ser Ile Leu Lys Val Val Met Lys Gln Cys Lys Asn Met Gln Glu Arg 
                85                  90                  95      


Met Leu Ser Gln Leu Ala Ala Ala Glu Ser Arg His Arg Lys Val Ile 
            100                 105                 110         


Leu Asp Leu Glu Glu Glu Arg Gln Arg His Ala Gln Asp Thr Ala Glu 
        115                 120                 125             


Gly Asp Asp Val Thr Tyr Met Leu Glu Lys Glu Arg Glu Arg Leu Thr 
    130                 135                 140                 


Gln Gln Leu Glu Phe Glu Lys Ser Gln Val Lys Lys Phe Glu Lys Glu 
145                 150                 155                 160 


Gln Lys Lys Leu Ser Ser Gln Leu Glu Glu Glu Arg Ser Arg His Lys 
                165                 170                 175     


Gln Leu Ser Ser Met Leu Val Leu Glu Cys Lys Lys Ala Thr Asn Lys 
            180                 185                 190         


Ala Ala Glu Glu Gly Gln Lys Ala Gly Glu Leu Ser Leu Lys Leu Glu 
        195                 200                 205             


Lys Glu Lys Ser Arg Val Ser Lys Leu Glu Glu Glu Leu Ala Ala Glu 
    210                 215                 220                 


Arg Lys Arg Gly Leu Gln Thr Glu Ala Gln Val Glu Lys Gln Leu Ser 
225                 230                 235                 240 


Glu Phe Asp Ile Glu Arg Glu Gln Leu Arg Ala Lys Leu Asn Arg Glu 
                245                 250                 255     


Glu Asn Arg Thr Lys Thr Leu Lys Glu Glu Met Glu Ser Leu Lys 
            260                 265                 270     


<210> 7845
<211> 493
<212> PRT
<213> Homo sapiens

<400> 7845
Met Asp Gln Asp Tyr Glu Arg Arg Leu Leu Arg Gln Ile Val Ile Gln 
1               5                   10                  15      


Asn Glu Asn Thr Met Pro Arg Val Thr Glu Met Arg Arg Thr Leu Thr 
            20                  25                  30          


Pro Ala Ser Ser Pro Val Ser Ser Pro Ser Lys His Gly Asp Arg Phe 
        35                  40                  45              


Ile Pro Ser Arg Ala Gly Ala Asn Trp Ser Val Asn Phe His Arg Ile 
    50                  55                  60                  


Asn Glu Asn Glu Lys Ser Pro Ser Gln Asn Arg Lys Ala Lys Asp Ala 
65                  70                  75                  80  


Thr Ser Asp Asn Gly Lys Asp Gly Leu Ala Tyr Ser Ala Leu Leu Lys 
                85                  90                  95      


Asn Glu Leu Leu Gly Ala Gly Ile Glu Lys Val Gln Asp Pro Gln Thr 
            100                 105                 110         


Glu Asp Arg Arg Leu Gln Pro Ser Thr Pro Glu Lys Lys Gly Leu Phe 
        115                 120                 125             


Thr Tyr Ser Leu Ser Thr Lys Arg Ser Ser Pro Asp Asp Gly Asn Asp 
    130                 135                 140                 


Val Ser Pro Tyr Ser Leu Ser Pro Val Ser Asn Lys Ser Gln Lys Leu 
145                 150                 155                 160 


Leu Arg Ser Pro Arg Lys Pro Thr Arg Lys Ile Ser Lys Ile Pro Phe 
                165                 170                 175     


Lys Val Leu Asp Ala Pro Glu Leu Gln Asp Asp Phe Tyr Leu Asn Leu 
            180                 185                 190         


Val Asp Trp Ser Ser Leu Asn Val Leu Ser Val Gly Leu Gly Thr Cys 
        195                 200                 205             


Val Tyr Leu Trp Ser Ala Cys Thr Ser Gln Val Thr Arg Leu Cys Asp 
    210                 215                 220                 


Leu Ser Val Glu Gly Asp Ser Val Thr Ser Val Gly Trp Ser Glu Arg 
225                 230                 235                 240 


Gly Asn Leu Val Ala Val Gly Thr His Lys Gly Phe Val Gln Ile Trp 
                245                 250                 255     


Asp Ala Ala Ala Gly Lys Lys Leu Ser Met Leu Glu Gly His Thr Ala 
            260                 265                 270         


Arg Val Gly Ala Leu Ala Trp Asn Ala Glu Gln Leu Ser Ser Gly Ser 
        275                 280                 285             


Arg Asp Arg Met Ile Leu Gln Arg Asp Ile Arg Thr Pro Pro Leu Gln 
    290                 295                 300                 


Ser Glu Arg Arg Leu Gln Gly His Arg Gln Glu Val Cys Gly Leu Lys 
305                 310                 315                 320 


Trp Ser Thr Asp His Gln Leu Leu Ala Ser Gly Gly Asn Asp Asn Lys 
                325                 330                 335     


Leu Leu Val Trp Asn His Ser Ser Leu Ser Pro Val Gln Gln Tyr Thr 
            340                 345                 350         


Glu His Leu Ala Ala Val Lys Ala Ile Ala Trp Ser Pro His Gln His 
        355                 360                 365             


Gly Leu Leu Ala Ser Gly Gly Gly Thr Ala Asp Arg Cys Ile Arg Phe 
    370                 375                 380                 


Trp Asn Thr Leu Thr Gly Gln Pro Leu Gln Cys Ile Asp Thr Gly Ser 
385                 390                 395                 400 


Gln Val Cys Asn Leu Ala Trp Ser Lys His Ala Asn Glu Leu Val Ser 
                405                 410                 415     


Thr His Gly Tyr Ser Gln Asn Gln Ile Leu Val Trp Lys Tyr Pro Ser 
            420                 425                 430         


Leu Thr Gln Val Ala Lys Leu Thr Gly His Ser Tyr Arg Val Leu Tyr 
        435                 440                 445             


Leu Ala Met Ser Pro Asp Gly Glu Ala Ile Val Thr Gly Ala Gly Asp 
    450                 455                 460                 


Glu Thr Leu Arg Phe Trp Asn Val Phe Ser Lys Thr Arg Ser Thr Lys 
465                 470                 475                 480 


Glu Ser Val Ser Val Leu Asn Leu Phe Thr Arg Ile Arg 
                485                 490             


<210> 7846
<211> 183
<212> PRT
<213> Homo sapiens

<400> 7846
Met Lys Lys Glu His Val Leu His Cys Gln Phe Ser Ala Trp Tyr Pro 
1               5                   10                  15      


Phe Phe Arg Gly Val Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
            20                  25                  30          


Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
        35                  40                  45              


Arg Asp Asp Pro Pro Thr His Ser Gln Pro Asp Ser Asp Asp Glu Ala 
    50                  55                  60                  


Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn Thr Ala Thr Leu Thr Asp 
65                  70                  75                  80  


Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Thr Leu Ser 
                85                  90                  95      


Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr Arg Asp Phe 
            100                 105                 110         


Thr Gln Pro Phe Ile His Cys Thr Asp Asp Ser Pro Asp Pro Cys Ile 
        115                 120                 125             


Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
    130                 135                 140                 


Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln 
145                 150                 155                 160 


Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu 
                165                 170                 175     


Ile Arg Arg Cys Ile Gln Asp 
            180             


<210> 7847
<211> 223
<212> PRT
<213> Homo sapiens

<400> 7847
Met Glu Asp Val Lys Leu Glu Phe Pro Ser Leu Pro Gln Cys Lys Glu 
1               5                   10                  15      


Asp Ala Glu Glu Trp Thr Tyr Pro Met Arg Arg Glu Met Gln Glu Ile 
            20                  25                  30          


Leu Pro Gly Leu Phe Leu Gly Pro Tyr Ser Ser Ala Met Lys Ser Lys 
        35                  40                  45              


Leu Pro Val Leu Gln Lys His Gly Ile Thr His Ile Ile Cys Ile Arg 
    50                  55                  60                  


Gln Asn Ile Glu Ala Asn Phe Ile Lys Pro Asn Phe Gln Gln Leu Phe 
65                  70                  75                  80  


Arg Tyr Leu Val Leu Asp Ile Ala Asp Asn Pro Val Glu Asn Ile Ile 
                85                  90                  95      


Arg Phe Phe Pro Met Thr Lys Glu Phe Ile Asp Gly Ser Leu Gln Met 
            100                 105                 110         


Gly Gly Lys Val Leu Val His Gly Asn Ala Gly Ile Ser Arg Ser Ala 
        115                 120                 125             


Ala Phe Val Ile Ala Tyr Ile Met Glu Thr Phe Gly Met Lys Tyr Arg 
    130                 135                 140                 


Asp Ala Phe Ala Tyr Val Gln Glu Arg Arg Phe Cys Ile Asn Pro Asn 
145                 150                 155                 160 


Ala Gly Phe Val His Gln Leu Gln Glu Tyr Glu Ala Ile Tyr Leu Ala 
                165                 170                 175     


Lys Leu Thr Ile Gln Met Met Ser Pro Leu Gln Ile Glu Arg Ser Leu 
            180                 185                 190         


Ser Val His Ser Gly Thr Thr Gly Ser Leu Lys Arg Thr His Glu Glu 
        195                 200                 205             


Glu Asp Asp Phe Gly Thr Met Gln Val Ala Thr Ala Gln Asn Gly 
    210                 215                 220             


<210> 7848
<211> 115
<212> PRT
<213> Homo sapiens

<400> 7848
Met Pro Ile Leu Leu Phe Leu Ile Asp Thr Ser Ala Ser Met Asn Gln 
1               5                   10                  15      


Arg Ser His Leu Gly Thr Thr Tyr Leu Asp Thr Ala Lys Gly Ala Val 
            20                  25                  30          


Glu Thr Phe Met Lys Leu Arg Ala Arg Asp Pro Ala Ser Arg Gly Asp 
        35                  40                  45              


Arg Tyr Met Leu Val Thr Phe Glu Glu Pro Pro Tyr Ala Ile Lys Ala 
    50                  55                  60                  


Gly Trp Lys Glu Asn His Ala Thr Phe Met Asn Glu Leu Lys Asn Leu 
65                  70                  75                  80  


Gln Ala Glu Gly Leu Thr Thr Leu Gly Gln Ser Leu Arg Thr Ala Phe 
                85                  90                  95      


Asp Leu Leu Asn Leu Asn Arg Leu Val Thr Gly Ile Asp Asn Tyr Gly 
            100                 105                 110         


Gln Val Gly 
        115 


<210> 7849
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7849
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7850
<211> 891
<212> PRT
<213> Homo sapiens

<400> 7850
Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly 
145                 150                 155                 160 


Phe Ala Leu Ala Leu Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Thr 
                165                 170                 175     


Trp Lys Thr Gly Gln Val Glu Arg Gly Arg Ala Trp Lys Pro Pro Ala 
            180                 185                 190         


Ser Leu Ala Leu Cys Ser Arg Ser Cys Asp Ser Met Val Ser Cys Tyr 
        195                 200                 205             


Ala Ser Ile Leu Cys Lys Ala Leu Trp Lys Glu Lys Leu His Thr Phe 
    210                 215                 220                 


Trp His His Asn Arg Ile Ser Phe Leu Pro Ser Ala Phe Arg Pro Ile 
225                 230                 235                 240 


Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg Ile His Ile Phe Ala 
                245                 250                 255     


Gln Gln Asn Asp Gln Phe Gln Lys Val Leu Ser Leu Cys Gly His Glu 
            260                 265                 270         


Asp Trp Ile Arg Gly Val Glu Trp Ala Ala Phe Gly Arg Asp Leu Phe 
        275                 280                 285             


Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg Ile Trp Lys Leu Tyr 
    290                 295                 300                 


Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp Asp Asn Ile Arg Leu 
305                 310                 315                 320 


Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser Val Lys Ile Ala Phe 
                325                 330                 335     


Ala Val Thr Leu Glu Thr Val Leu Ala Gly His Glu Asn Trp Val Asn 
            340                 345                 350         


Ala Val His Trp Gln Pro Val Phe Tyr Lys Asp Gly Val Leu Gln Gln 
        355                 360                 365             


Pro Val Arg Leu Leu Ser Ala Ser Met Asp Lys Thr Met Ile Leu Trp 
    370                 375                 380                 


Ala Pro Asp Glu Glu Ser Gly Val Trp Leu Glu Gln Val Arg Val Gly 
385                 390                 395                 400 


Glu Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp Cys Gln Phe Asn Glu 
                405                 410                 415     


Asp Gly Ser Met Ile Ile Ala His Ala Phe His Gly Ala Leu His Leu 
            420                 425                 430         


Trp Lys Gln Asn Thr Val Asn Pro Arg Glu Trp Thr Pro Glu Ile Val 
        435                 440                 445             


Ile Ser Gly His Phe Asp Gly Val Gln Asp Leu Val Trp Asp Pro Glu 
    450                 455                 460                 


Gly Glu Phe Ile Ile Thr Val Gly Thr Asp Gln Thr Thr Arg Leu Phe 
465                 470                 475                 480 


Ala Pro Trp Lys Arg Lys Asp Gln Ser Gln Val Thr Trp His Glu Ile 
                485                 490                 495     


Ala Arg Pro Gln Ile His Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile 
            500                 505                 510         


Asn Arg Phe Gln Phe Val Ser Gly Ala Asp Glu Lys Val Leu Arg Val 
        515                 520                 525             


Phe Ser Ala Pro Arg Asn Phe Val Glu Asn Phe Cys Ala Ile Thr Gly 
    530                 535                 540                 


Gln Ser Leu Asn His Val Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu 
545                 550                 555                 560 


Gly Ala Thr Val Pro Ala Leu Gly Leu Ser Asn Lys Ala Val Phe Gln 
                565                 570                 575     


Gly Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser 
            580                 585                 590         


Thr Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln Pro Ser Ile Leu Thr 
        595                 600                 605             


Glu Pro Pro Thr Glu Asp His Leu Leu Gln Asn Thr Leu Trp Pro Glu 
    610                 615                 620                 


Val Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile Phe Cys Val Thr Cys 
625                 630                 635                 640 


Asn Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys 
                645                 650                 655     


Glu His Ala Ala Ile Ile Leu Trp Asn Thr Thr Ser Trp Lys Gln Val 
            660                 665                 670         


Gln Asn Leu Val Phe His Ser Leu Thr Val Thr Gln Met Ala Phe Ser 
        675                 680                 685             


Pro Asn Glu Lys Phe Leu Leu Ala Val Ser Arg Asp Arg Thr Trp Ser 
    690                 695                 700                 


Leu Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu Phe Glu Pro Val Phe 
705                 710                 715                 720 


Ser Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser Val His Ser Arg Ile 
                725                 730                 735     


Ile Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly 
            740                 745                 750         


Ser Arg Asp Lys Lys Val Val Val Trp Gly Glu Cys Asp Ser Thr Asp 
        755                 760                 765             


Asp Cys Ile Glu His Asn Ile Gly Pro Cys Ser Ser Val Leu Asp Val 
    770                 775                 780                 


Gly Gly Ala Val Thr Ala Val Ser Val Cys Pro Val Leu His Pro Ser 
785                 790                 795                 800 


Gln Arg Tyr Val Val Ala Val Gly Leu Glu Cys Gly Lys Ile Cys Leu 
                805                 810                 815     


Tyr Thr Trp Lys Lys Thr Asp Gln Val Pro Glu Ile Asn Asp Trp Thr 
            820                 825                 830         


His Cys Val Glu Thr Ser Gln Ser Gln Ser His Thr Leu Ala Ile Arg 
        835                 840                 845             


Lys Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala 
    850                 855                 860                 


Glu Gly Ala Glu Trp Leu His Phe Ala Ser Cys Gly Glu Asp His Thr 
865                 870                 875                 880 


Val Lys Ile His Arg Val Asn Lys Cys Ala Leu 
                885                 890     


<210> 7851
<211> 190
<212> PRT
<213> Homo sapiens

<400> 7851
Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala Ala Glu Lys 
    130                 135                 140                 


Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu Lys Ile Ala 
145                 150                 155                 160 


Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu Ala Ala Cys 
                165                 170                 175     


Arg Tyr Gly Glu Arg Ser Gly Trp Ala Leu Tyr Leu Gln Pro 
            180                 185                 190 


<210> 7852
<211> 493
<212> PRT
<213> Homo sapiens

<400> 7852
Met Met Lys Arg Gln Leu His Arg Met Arg Gln Leu Ala Gln Thr Gly 
1               5                   10                  15      


Ser Leu Gly Arg Thr Pro Glu Thr Ala Glu Phe Leu Gly Glu Asp Leu 
            20                  25                  30          


Leu Gln Val Glu Gln Arg Leu Glu Pro Ala Lys Arg Ala Ala His Asn 
        35                  40                  45              


Ile His Lys Arg Leu Gln Ala Cys Leu Gln Gly Gln Ser Gly Ala Asp 
    50                  55                  60                  


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
65                  70                  75                  80  


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
                85                  90                  95      


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
            100                 105                 110         


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
        115                 120                 125             


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
    130                 135                 140                 


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
145                 150                 155                 160 


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
                165                 170                 175     


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
            180                 185                 190         


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
        195                 200                 205             


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
    210                 215                 220                 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
225                 230                 235                 240 


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
                245                 250                 255     


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
            260                 265                 270         


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
        275                 280                 285             


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
    290                 295                 300                 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
305                 310                 315                 320 


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
                325                 330                 335     


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
            340                 345                 350         


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
        355                 360                 365             


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
    370                 375                 380                 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
385                 390                 395                 400 


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
                405                 410                 415     


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
            420                 425                 430         


Trp Pro Pro Glu Lys Glu Gly Leu Glu Tyr Ser Gly Ala Ile Ser Ala 
        435                 440                 445             


His Cys Asn Leu Arg Leu Pro Gly Ser Ser Asp Ser Ser Ala Ser Ala 
    450                 455                 460                 


Cys Gln Val Ala Gly Thr Thr Gly Thr Arg Pro Ser Trp Met Gln Pro 
465                 470                 475                 480 


Pro Cys Leu Pro Ser Arg Trp Trp Ala Ser Ser Arg Arg 
                485                 490             


<210> 7853
<211> 14
<212> PRT
<213> Homo sapiens

<400> 7853
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr 
1               5                   10                  


<210> 7854
<211> 275
<212> PRT
<213> Homo sapiens

<400> 7854
Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210> 7855
<211> 501
<212> PRT
<213> Homo sapiens

<400> 7855
Met Ala Ala Pro Glu Pro Ala Pro Arg Arg Ala Arg Glu Arg Glu Arg 
1               5                   10                  15      


Glu Arg Glu Asp Glu Ser Glu Asp Glu Ser Asp Ile Leu Glu Glu Ser 
            20                  25                  30          


Pro Cys Gly Arg Trp Gln Lys Arg Arg Glu Gln Val Asn Gln Gly Asn 
        35                  40                  45              


Met Pro Gly Leu Gln Ser Thr Phe Leu Ala Met Asp Thr Glu Glu Gly 
    50                  55                  60                  


Val Glu Val Val Trp Asn Glu Leu His Phe Gly Asp Arg Lys Ala Phe 
65                  70                  75                  80  


Ala Ala His Glu Glu Lys Ile Gln Thr Val Phe Glu Gln Leu Val Leu 
                85                  90                  95      


Val Asp His Pro Asn Ile Val Lys Leu His Lys Tyr Trp Leu Asp Thr 
            100                 105                 110         


Ser Glu Ala Cys Ala Arg Val Ile Phe Ile Thr Glu Tyr Val Ser Ser 
        115                 120                 125             


Gly Ser Leu Lys Gln Phe Leu Lys Lys Thr Lys Lys Asn His Lys Ala 
    130                 135                 140                 


Met Asn Ala Arg Ala Trp Lys Arg Trp Cys Thr Gln Ile Leu Ser Ala 
145                 150                 155                 160 


Leu Ser Phe Leu His Ala Cys Ser Pro Pro Ile Ile His Gly Asn Leu 
                165                 170                 175     


Thr Ser Asp Thr Ile Phe Ile Gln His Asn Gly Leu Ile Lys Ile Gly 
            180                 185                 190         


Ser Val Trp His Arg Ile Phe Ser Asn Ala Leu Pro Asp Asp Leu Arg 
        195                 200                 205             


Ser Pro Ile Arg Ala Glu Arg Glu Glu Leu Arg Asn Leu His Phe Phe 
    210                 215                 220                 


Pro Pro Glu Tyr Gly Glu Val Ala Asp Gly Thr Ala Val Asp Ile Phe 
225                 230                 235                 240 


Ser Phe Gly Met Cys Ala Leu Glu Met Ala Val Leu Glu Ile Gln Thr 
                245                 250                 255     


Asn Gly Asp Thr Arg Val Thr Glu Glu Ala Ile Ala Arg Ala Arg His 
            260                 265                 270         


Ser Leu Ser Asp Pro Asn Met Arg Glu Phe Ile Leu Cys Cys Leu Ala 
        275                 280                 285             


Arg Asp Pro Ala Arg Arg Pro Ser Ala His Ser Leu Leu Phe His Arg 
    290                 295                 300                 


Val Leu Phe Glu Val His Ser Leu Lys Leu Leu Ala Ala His Cys Phe 
305                 310                 315                 320 


Ile Gln His Gln Tyr Leu Met Pro Glu Asn Val Val Glu Glu Lys Thr 
                325                 330                 335     


Lys Ala Met Asp Leu His Ala Val Leu Ala Glu Leu Pro Arg Pro Arg 
            340                 345                 350         


Arg Pro Pro Leu Gln Trp Arg Tyr Ser Glu Val Ser Phe Met Glu Leu 
        355                 360                 365             


Asp Lys Phe Leu Glu Asp Val Arg Asn Gly Ile Tyr Pro Leu Met Asn 
    370                 375                 380                 


Phe Ala Ala Thr Arg Pro Leu Gly Leu Pro Arg Val Leu Ala Pro Pro 
385                 390                 395                 400 


Pro Glu Glu Val Gln Lys Ala Lys Thr Pro Thr Pro Glu Pro Phe Asp 
                405                 410                 415     


Ser Glu Thr Arg Lys Val Ile Gln Met Gln Cys Asn Leu Glu Arg Ser 
            420                 425                 430         


Glu Asp Lys Ala Arg Trp His Leu Thr Leu Leu Leu Val Leu Glu Asp 
        435                 440                 445             


Arg Leu His Arg Gln Leu Thr Tyr Asp Leu Leu Pro Thr Asp Ser Ala 
    450                 455                 460                 


Gln Asp Leu Ala Ser Glu Leu Val His Tyr Gly Phe Leu His Glu Asp 
465                 470                 475                 480 


Asp Arg Met Lys Leu Ala Ala Phe Leu Glu Ser Thr Phe Leu Lys Tyr 
                485                 490                 495     


Arg Gly Thr Gln Ala 
            500     


<210> 7856
<211> 11
<212> PRT
<213> Homo sapiens

<400> 7856
Met Thr Ala Pro Ser Cys Ala Phe Pro Val Gln 
1               5                   10      


<210> 7857
<211> 177
<212> PRT
<213> Homo sapiens

<400> 7857
Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile Asp 
1               5                   10                  15      


Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn Ile 
            20                  25                  30          


Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu Pro 
        35                  40                  45              


Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr Ile 
    50                  55                  60                  


Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu Thr 
65                  70                  75                  80  


Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr Phe 
                85                  90                  95      


Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu Val 
            100                 105                 110         


Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His Ser 
        115                 120                 125             


Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser Gly 
    130                 135                 140                 


Arg Lys Pro Glu Arg Arg Arg Leu Lys Thr Thr Arg Leu Lys Glu Tyr 
145                 150                 155                 160 


Thr Ile Lys Ser His Ser Ser Ala Ser Pro Ile Val Ala Pro Val Asp 
                165                 170                 175     


Ala 
    


<210> 7858
<211> 204
<212> PRT
<213> Homo sapiens

<400> 7858
Met Gly Asp Lys Lys Ser Pro Thr Arg Pro Lys Arg Gln Pro Lys Pro 
1               5                   10                  15      


Ser Ser Asp Glu Gly Tyr Trp Asp Cys Ser Val Cys Thr Phe Arg Asn 
            20                  25                  30          


Ser Ala Glu Ala Phe Lys Cys Met Met Cys Asp Val Arg Lys Gly Thr 
        35                  40                  45              


Ser Thr Arg Ser Thr Leu Phe Glu Val Ile Val Ser Ala Ser Arg Thr 
    50                  55                  60                  


Lys Glu Pro Leu Lys Phe Pro Ile Ser Gly Arg Lys Pro Arg Pro Val 
65                  70                  75                  80  


Ser Gln Leu Val Ala Gln Gln Val Thr Gln Gln Phe Val Pro Pro Thr 
                85                  90                  95      


Gln Ser Lys Lys Glu Lys Lys Asp Lys Val Glu Lys Glu Lys Ser Glu 
            100                 105                 110         


Lys Glu Thr Thr Ser Lys Lys Asn Ser His Lys Lys Thr Arg Pro Arg 
        115                 120                 125             


Leu Lys Asn Val Asp Arg Ser Ser Ala Gln His Leu Glu Val Thr Val 
    130                 135                 140                 


Gly Asp Leu Thr Val Ile Ile Thr Asp Phe Lys Glu Lys Thr Lys Ser 
145                 150                 155                 160 


Pro Pro Ala Ser Ser Ala Ala Ser Ala Asp Gln His Ser Gln Ser Gly 
                165                 170                 175     


Ser Ser Ser Asp Asn Thr Glu Arg Gly Met Ser Arg Ser Ser Ser Pro 
            180                 185                 190         


Arg Gly Glu Ala Ser Ser Leu Asn Gly Glu Ser His 
        195                 200                 


<210> 7859
<211> 449
<212> PRT
<213> Homo sapiens

<400> 7859
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210> 7860
<211> 50
<212> PRT
<213> Homo sapiens

<400> 7860
Lys Thr Gly Leu Thr Gly Ser Pro Ser Ser Leu Trp Asp Leu Leu Arg 
1               5                   10                  15      


Glu Met Phe Val Val Cys Ser Lys Glu Gln Leu Gln Ser Gly Gly Lys 
            20                  25                  30          


Tyr Ser His Gln Val Trp Ala Pro Phe Ser Pro Leu Ala Ser Gly Ala 
        35                  40                  45              


Ala Phe 
    50  


<210> 7861
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 7861
Met Gln Arg Glu Leu Val Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro 
1               5                   10                  15      


Arg Pro Gly Ser Thr Ala His Pro Pro His Ala Ile Pro Asn Ser Pro 
            20                  25                  30          


Pro Ser Thr Pro Val Pro His Ser Met Pro Pro Ser Pro Ser Arg Ile 
        35                  40                  45              


Pro Tyr Gly Gly Thr Arg Ser Met Val Val Pro Gly Asn Ala Thr Ile 
    50                  55                  60                  


Pro Arg Asp Arg Ile Ser Ser Leu Pro Val Ser Arg Pro Ile Ser Pro 
65                  70                  75                  80  


Ser Pro Ser Ala Ile Leu Glu Arg Arg Asp Val Lys Pro Asp Glu Asp 
                85                  90                  95      


Met Ser Gly Lys Asn Ile Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala 
            100                 105                 110         


Asp Pro Tyr Leu Tyr His Glu Gly Arg Met Ser Ile Ala Ser Ser His 
        115                 120                 125             


Gly Gly His Pro Leu Asp Val Pro Asp His Ile Ile Ala Tyr His Arg 
    130                 135                 140                 


Thr Ala Ile Arg Ser Ala Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala 
145                 150                 155                 160 


Glu Met His Met Glu Gln Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr 
                165                 170                 175     


Pro Asp Ser His Leu Pro Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser 
            180                 185                 190         


Pro His Arg Val Ser Asp Leu Arg Met Ile Asp Met His Ala His Tyr 
        195                 200                 205             


Asn Ala His Gly Pro Pro His Thr Met Gln Pro Asp Arg Ala Ser Pro 
    210                 215                 220                 


Ser Arg Gln Ala Phe Lys Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu 
225                 230                 235                 240 


Lys Pro Arg Ser Ala Ala Gly Leu Ser Ser Leu Val Asp Leu Gly Pro 
                245                 250                 255     


Pro Leu Met Glu Lys Gln Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro 
            260                 265                 270         


Lys Asp Arg Glu Thr Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg 
        275                 280                 285             


Asn His Thr Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met 
    290                 295                 300                 


Leu Ser Ala Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val 
305                 310                 315                 320 


Gly Thr Ser Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val 
                325                 330                 335     


Ala Glu Leu Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln 
            340                 345                 350         


Asn Gln Glu Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile 
        355                 360                 365             


Ser Gly Lys Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln 
    370                 375                 380                 


Arg Gln Arg Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu 
385                 390                 395                 400 


Glu Glu Lys Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu 
                405                 410                 415     


Asp Leu Lys Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys 
            420                 425                 430         


Asp Val Glu Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val 
        435                 440                 445             


Ala Thr Leu Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala 
    450                 455                 460                 


Ile Leu Arg Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro 
465                 470                 475                 480 


His Lys Leu Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val 
                485                 490                 495     


Leu Thr Met Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr 
            500                 505                 510         


Asp Ala Ala Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala 
        515                 520                 525             


Ala Glu Val Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln 
    530                 535                 540                 


Pro Phe His Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val 
545                 550                 555                 560 


Pro Leu Ser Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val 
                565                 570                 575     


Ile Gln Pro Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn 
            580                 585                 590         


Leu Pro His Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser 
        595                 600                 605             


Thr Leu Gln Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn 
    610                 615                 620                 


Gly Ser Ala Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser 
625                 630                 635                 640 


Ala Lys Asn Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu 
                645                 650                 655     


Glu Lys Arg Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys 
            660                 665                 670         


Leu Leu Glu Glu Ala Gln Ala Asn Ile Met Lys Ser Ile Pro Asn Leu 
        675                 680                 685             


Glu Met Pro Pro Ala Thr Gly Pro Leu Pro Arg Gly Asp Ala Pro Val 
    690                 695                 700                 


Asp Lys Val Glu Leu Ser Glu Asp Ser Pro Asn Ser Glu Gln Asp Leu 
705                 710                 715                 720 


Glu Lys Leu Gly Gly Lys Ser Pro Pro Pro Pro Pro Pro Pro Pro Arg 
                725                 730                 735     


Arg Ser Tyr Leu Pro Gly Ser Gly Leu Thr Thr Thr Arg Ser Gly Asp 
            740                 745                 750         


Val Val Tyr Thr Gly Arg Lys Glu Asn Ile Thr Ala Lys Ala Ser Ser 
        755                 760                 765             


Glu Asp Ala Gly Pro Ser Pro Gln Thr Arg Ala Thr Lys Tyr Pro Ala 
    770                 775                 780                 


Glu Glu Pro Ala Ser Ala Trp Thr Pro Ser Pro Pro Pro Val Thr Thr 
785                 790                 795                 800 


Ser Ser Ser Lys Asp Glu Glu Glu Glu Glu Glu Glu Gly Asp Lys Ile 
                805                 810                 815     


Met Ala Glu Leu Gln Ala Phe Gln Lys Cys Ser Phe Met Asp Val Asn 
            820                 825                 830         


Ser Asn Ser His Ala Glu Pro Ser Arg Ala Asp Ser His Val Lys Asp 
        835                 840                 845             


Thr Arg Ser Gly Ala Thr Val Pro Pro Lys Glu Lys Lys Asn Leu Glu 
    850                 855                 860                 


Phe Phe His Glu Asp Val Arg Lys Ser Asp Val Glu Tyr Glu Asn Gly 
865                 870                 875                 880 


Pro Gln Met Glu Phe Gln Lys Val Thr Thr Gly Ala Val Arg Pro Ser 
                885                 890                 895     


Asp Pro Pro Lys Trp Glu Arg Gly Met Glu Asn Ser Ile Ser Asp Ala 
            900                 905                 910         


Ser Arg Thr Ser Glu Tyr Lys Thr Glu Ile Ile Met Lys Glu Asn Ser 
        915                 920                 925             


Ile Ser Asn Met Ser Leu Leu Arg Asp Ser Arg Asn Tyr Ser Gln Glu 
    930                 935                 940                 


Thr Val Pro Lys Ala Ser Phe Gly Phe Ser Gly Ile Ser Pro Leu Glu 
945                 950                 955                 960 


Asp Glu Ile Asn Lys Gly Ser Lys Ile Ser Gly Leu Gln Tyr Ser Ile 
                965                 970                 975     


Pro Asp Thr Glu Asn Gln Thr Leu Asn Tyr Gly Lys Thr Lys Glu Met 
            980                 985                 990         


Glu Lys Gln Asn Thr Asp Lys Cys  His Val Ser Ser His  Thr Arg Leu 
        995                 1000                 1005             


Thr Glu  Ser Ser Val His Asp  Phe Lys Thr Glu Asp  Gln Glu Val 
    1010                 1015                 1020             


Ile Thr  Thr Asp Phe Gly Gln  Val Val Leu Arg Pro  Lys Glu Ala 
    1025                 1030                 1035             


Arg His  Ala Asn Val Asn Pro  Asn Glu Asp Gly Glu  Ser Ser Ser 
    1040                 1045                 1050             


Ser Ser  Pro Thr Glu Glu Asn  Ala Ala Thr Asp Asn  Ile Ala Phe 
    1055                 1060                 1065             


Met Ile  Thr Glu Thr Thr Val  Gln Val Leu Ser Ser  Gly Glu Val 
    1070                 1075                 1080             


His Asp  Ile Val Ser Gln Lys  Gly Glu Asp Ile Gln  Thr Val Asn 
    1085                 1090                 1095             


Ile Asp  Ala Arg Lys Glu Met  Thr Pro Arg Gln Glu  Gly Thr Asp 
    1100                 1105                 1110             


Asn Glu  Asp Pro Val Val Cys  Leu Asp Lys Lys Pro  Val Ile Ile 
    1115                 1120                 1125             


Ile Phe  Asp Glu Pro Met Asp  Ile Arg Ser Ala Tyr  Lys Arg Leu 
    1130                 1135                 1140             


Ser Thr  Ile Phe Glu Glu Cys  Asp Glu Glu Leu Glu  Arg Met Met 
    1145                 1150                 1155             


Met Glu  Glu Lys Ile Glu Glu  Glu Glu Glu Glu Glu  Asn Gly Asp 
    1160                 1165                 1170             


Ser Val  Val Gln Asn Asn Asn  Thr Ser Gln Met Ser  His Lys Lys 
    1175                 1180                 1185             


Val Ala  Pro Gly Asn Leu Arg  Thr Gly Gln Gln Val  Glu Thr Lys 
    1190                 1195                 1200             


Ser Gln  Pro His Ser Leu Ala  Thr Glu Thr Arg Asn  Pro Gly Gly 
    1205                 1210                 1215             


Gln Glu  Met Asn Arg Thr Glu  Leu Asn Lys Phe Ser  His Val Asp 
    1220                 1225                 1230             


Ser Pro  Asn Ser Glu Cys Lys  Gly Glu Asp Ala Thr  Asp Asp Gln 
    1235                 1240                 1245             


Phe Glu  Ser Pro Lys Lys Lys  Phe Lys Phe Lys Phe  Pro Lys Lys 
    1250                 1255                 1260             


Gln Leu  Ala Ala Leu Thr Gln  Ala Ile Arg Thr Gly  Thr Lys Thr 
    1265                 1270                 1275             


Gly Lys  Lys Thr Leu Gln Val  Val Val Tyr Glu Glu  Glu Glu Glu 
    1280                 1285                 1290             


Asp Gly  Thr Leu Lys Gln His  Lys Glu Ala Lys Arg  Phe Glu Ile 
    1295                 1300                 1305             


Ala Arg  Ser Gln Pro Glu Asp  Thr Pro Glu Asn Thr  Val Arg Arg 
    1310                 1315                 1320             


Gln Glu  Gln Pro Ser Ile Glu  Ser Thr Ser Pro Ile  Ser Arg Thr 
    1325                 1330                 1335             


Asp Glu  Ile Arg Lys Asn Thr  Tyr Arg Thr Leu Asp  Ser Leu Glu 
    1340                 1345                 1350             


Gln Thr  Ile Lys Gln Leu Glu  Asn Thr Ile Ser Glu  Met Ser Pro 
    1355                 1360                 1365             


Lys Ala  Leu Val Asp Thr Ser  Cys Ser Ser Asn Arg  Asp Ser Val 
    1370                 1375                 1380             


Ala Ser  Ser Ser His Ile Ala  Gln Glu Ala Ser Pro  Arg Pro Leu 
    1385                 1390                 1395             


Leu Val  Pro Asp Glu Gly Pro  Thr Ala Leu Glu Pro  Pro Thr Ser 
    1400                 1405                 1410             


Ile Pro  Ser Ala Ser Arg Lys  Gly Ser Ser Gly Ala  Pro Gln Thr 
    1415                 1420                 1425             


Ser Arg  Met Pro Val Pro Met  Ser Ala Lys Asn Arg  Pro Gly Thr 
    1430                 1435                 1440             


Leu Asp  Lys Pro Gly Lys Gln  Ser Lys Leu Gln Asp  Pro Arg Gln 
    1445                 1450                 1455             


Tyr Arg  Gln 
    1460     


<210> 7862
<211> 705
<212> PRT
<213> Homo sapiens

<400> 7862
Met Leu Thr Leu Leu Ala Glu Asp Arg Ala Val Pro Ser Ala Pro Thr 
1               5                   10                  15      


Gly Pro Gly Pro Leu Leu Glu Phe Ala Leu His Glu Asp Leu Leu Thr 
            20                  25                  30          


Arg Val Leu Thr Trp Gln Leu Gln Trp Asp Glu Leu Gly Asp Gly Val 
        35                  40                  45              


Glu Glu Arg Arg Ala Glu Gln Leu Lys Leu Phe Glu Met Leu Val Ser 
    50                  55                  60                  


Glu Ala Arg Gln Pro Leu Leu Arg His Gly Pro Val Arg Glu Ala Leu 
65                  70                  75                  80  


Leu Thr Leu Leu Asp Ala Cys Gly Arg Pro Val Pro Ser Ser Pro Ala 
                85                  90                  95      


Leu Asp Glu Gly Leu Val Leu Leu Leu Ser Gln Leu Cys Val Cys Val 
            100                 105                 110         


Ala Gln Glu Pro Ser Leu Leu Glu Phe Phe Leu Gln Pro Pro Pro Glu 
        115                 120                 125             


Pro Gly Ala Ala Pro Arg Leu Leu Leu Phe Ser Arg Leu Val Pro Phe 
    130                 135                 140                 


Val His Arg Glu Gly Thr Leu Gly Gln Gln Ala Arg Asp Ala Leu Leu 
145                 150                 155                 160 


Leu Leu Met Ala Leu Ser Ala Gly Ser Pro Thr Val Gly Arg Tyr Ile 
                165                 170                 175     


Ala Asp His Ser Tyr Phe Cys Pro Val Leu Ala Thr Gly Leu Ser Ala 
            180                 185                 190         


Leu Tyr Ser Ser Leu Pro Arg Lys Ile Glu Val Pro Gly Asp Asp Trp 
        195                 200                 205             


His Cys Leu Arg Arg Glu Asp Trp Leu Gly Val Pro Ala Leu Ala Leu 
    210                 215                 220                 


Phe Met Ser Ser Leu Glu Phe Cys Asn Ala Val Ile Gln Val Ala His 
225                 230                 235                 240 


Pro Leu Val Gln Lys Gln Leu Val Asp Tyr Ile His Asn Gly Phe Leu 
                245                 250                 255     


Val Pro Val Met Gly Pro Ala Leu His Lys Thr Ser Val Glu Glu Met 
            260                 265                 270         


Ile Ala Ser Thr Ala Tyr Leu Glu Leu Phe Leu Arg Ser Ile Ser Glu 
        275                 280                 285             


Pro Ala Leu Leu Arg Thr Phe Leu Arg Phe Leu Leu Leu His Arg His 
    290                 295                 300                 


Asp Thr His Thr Ile Leu Asp Thr Leu Val Ala Arg Ile Gly Ser Asn 
305                 310                 315                 320 


Ser Arg Leu Cys Met Val Ser Leu Ser Leu Phe Arg Thr Leu Leu Asn 
                325                 330                 335     


Leu Ser Cys Glu Asp Val Leu Leu Gln Leu Val Leu Arg Tyr Leu Val 
            340                 345                 350         


Pro Cys Asn His Val Met Leu Ser Gln Lys Pro Ala Val Arg Asp Val 
        355                 360                 365             


Asp Leu Tyr Gly Arg Ala Ala Asp Lys Phe Leu Ser Leu Ile Pro Arg 
    370                 375                 380                 


Cys Cys Arg His His Ala Pro Ser Pro Pro Arg Pro Glu His Ala Ser 
385                 390                 395                 400 


Trp Ala Arg Gly Pro Gly Ser Pro Ser Val Asp Ser Ser Ser Val Thr 
                405                 410                 415     


Thr Val Pro Arg Pro Ser Thr Pro Ser Arg Leu Ala Leu Phe Leu Arg 
            420                 425                 430         


Gln Gln Ser Leu Gly Gly Ser Glu Ser Pro Gly Pro Ala Pro Cys Ser 
        435                 440                 445             


Pro Gly Leu Ser Ala Ser Pro Ala Ser Ser Pro Gly Arg Arg Pro Thr 
    450                 455                 460                 


Pro Ala Glu Glu Pro Gly Glu Leu Glu Asp Asn Tyr Leu Glu Tyr Leu 
465                 470                 475                 480 


Arg Glu Ala Arg Arg Gly Val Asp Arg Cys Val Arg Ala Cys Arg Thr 
                485                 490                 495     


Trp Ser Ala Pro Tyr Asp Gly Glu Arg Pro Ser Pro Glu Pro Ser Pro 
            500                 505                 510         


Phe Gly Ser Arg Thr Lys Lys Arg Ser Leu Leu Pro Glu Glu Asp Arg 
        515                 520                 525             


Asn Asn Val Gly Glu Gly Glu Glu Glu Glu Leu Gly Arg Arg Gly Arg 
    530                 535                 540                 


Ala Gly Gly Ala Gly Glu Gly Pro Gly His Leu Pro Pro Pro Gln Leu 
545                 550                 555                 560 


Asn Gly Val Pro Gly Ser Trp Pro Glu Gly Ala Lys Lys Val Arg Leu 
                565                 570                 575     


Val Pro Lys Glu Gly Ala Gly Glu Leu Leu Glu Gly Ile Ser Glu Gly 
            580                 585                 590         


Met Ala Gly Leu Glu Gly Phe Gly Gln Glu Leu Arg Glu Leu Glu Val 
        595                 600                 605             


Ala Leu Ser Asn Gly Gly Thr Gly Ser Glu Ser Pro Leu Glu Pro Pro 
    610                 615                 620                 


Leu Pro Leu Glu Glu Glu Glu Ala Tyr Glu Ser Phe Thr Cys Pro Pro 
625                 630                 635                 640 


Glu Pro Pro Gly Pro Phe Leu Ser Ser Pro Leu Arg Thr Leu Asn Gln 
                645                 650                 655     


Leu Pro Ser Gln Pro Phe Thr Gly Pro Phe Met Ala Val Leu Phe Ala 
            660                 665                 670         


Lys Leu Glu Asn Met Leu Gln Asn Ser Ala Leu Ser Cys Ser Thr Pro 
        675                 680                 685             


Thr Trp Ser Ser Ser Pro Val Ser Ser Pro Cys Cys Arg Cys Trp Ala 
    690                 695                 700                 


Leu 
705 


<210> 7863
<211> 267
<212> PRT
<213> Homo sapiens

<400> 7863
Met Met Arg Gly Tyr Ile Lys Lys Val Leu Lys Asn Thr Ser Tyr His 
1               5                   10                  15      


Val Asn Gln Tyr Leu Phe Ile Gln His Gly Trp Ser Gly Ser Gly Asp 
            20                  25                  30          


Gln Ser Val Leu Tyr Ser Cys Asn Leu Met Arg Met Val Thr Arg Thr 
        35                  40                  45              


Lys Lys Ile Phe Val Gly Gly Leu Ser Ala Asn Thr Val Val Glu Asp 
    50                  55                  60                  


Val Lys Gln Tyr Phe Glu Gln Phe Gly Lys Val Glu Asp Ala Met Leu 
65                  70                  75                  80  


Met Phe Asp Lys Thr Thr Asn Arg His Arg Gly Phe Gly Phe Val Thr 
                85                  90                  95      


Phe Glu Asn Glu Asp Val Val Glu Lys Val Cys Glu Ile His Phe His 
            100                 105                 110         


Glu Ile Asn Asn Lys Met Val Glu Cys Lys Lys Ala Gln Pro Lys Glu 
        115                 120                 125             


Val Met Phe Pro Pro Gly Thr Arg Gly Arg Ala Arg Gly Leu Pro Tyr 
    130                 135                 140                 


Thr Met Asp Ala Phe Met Leu Gly Met Gly Met Leu Gly Tyr Pro Asn 
145                 150                 155                 160 


Phe Val Ala Thr Tyr Gly Arg Gly Tyr Pro Gly Phe Ala Pro Ser Tyr 
                165                 170                 175     


Gly Tyr Gln Phe Pro Gly Phe Pro Ala Ala Ala Tyr Gly Pro Val Ala 
            180                 185                 190         


Ala Ala Ala Val Ala Ala Ala Arg Gly Ser Gly Ser Asn Pro Ala Arg 
        195                 200                 205             


Pro Gly Gly Phe Pro Gly Ala Asn Ser Pro Gly Pro Val Ala Asp Leu 
    210                 215                 220                 


Tyr Gly Pro Ala Ser Gln Asp Ser Gly Val Gly Asn Tyr Ile Ser Ala 
225                 230                 235                 240 


Ala Ser Pro Gln Pro Gly Ser Gly Phe Gly His Gly Ile Ala Gly Pro 
                245                 250                 255     


Leu Ile Ala Thr Ala Phe Thr Asn Gly Tyr His 
            260                 265         


<210> 7864
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7864
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Gly Leu Ile Gly Ala Pro 
145                 150                 155                 160 


<210> 7865
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7865
Xaa Ser Val Gln Ser Pro Ala Gln Gln Gln Val Pro Ala Arg Pro Gly 
1               5                   10                  15      


Ala Pro Ser Val Gln Val Pro Ser Pro Phe Leu Leu Gln Asn Gln Tyr 
            20                  25                  30          


Glu Pro Val Gln Pro His Trp Phe Tyr Cys Lys Glu Val Glu Tyr Lys 
        35                  40                  45              


Gln Leu Trp Met Pro Phe Ser Val Phe Asp Ser Leu Asn Leu Glu Glu 
    50                  55                  60                  


Ile Tyr Asn Ser Val Gln Pro Asp Pro Glu Ser Val Val Leu Gly Thr 
65                  70                  75                  80  


Asp Gly Gly Arg Tyr Asp Val Tyr Leu Tyr Asp Arg Ile Arg Lys Ala 
                85                  90                  95      


Ala Tyr Trp Glu Glu Glu Pro Ala Glu Val Arg Arg Cys Thr Trp Phe 
            100                 105                 110         


Tyr Lys Gly Asp Thr Asp Ser Arg Phe Ile Pro Tyr Thr Glu Glu Phe 
        115                 120                 125             


Ser Glu Lys Leu Glu Val Arg Val Leu Tyr Phe Phe Met Ser Phe Phe 
    130                 135                 140                 


Lys Lys Cys Arg Ser Tyr Ile His Trp 
145                 150             


<210> 7866
<211> 353
<212> PRT
<213> Homo sapiens

<400> 7866
Met Glu Gln Glu Leu Glu Gln Leu Ala Gln Leu Pro Ser Ser Lys Asn 
1               5                   10                  15      


Ser Leu Leu Lys Asp Ala Met Ala Pro Gly Thr Pro Lys Ser Leu Leu 
            20                  25                  30          


Leu Ser Ala Ser Ile Lys Arg Glu Gly Glu Ser Pro Thr Ala Ser Pro 
        35                  40                  45              


His Ser Ser Ala Thr Asp Asp Leu His His Ser Asp Arg Tyr Gln Thr 
    50                  55                  60                  


Phe Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn Ala Arg Ile 
65                  70                  75                  80  


Gly Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Val Cys Pro Leu 
                85                  90                  95      


Cys Asn Arg Pro Leu Ala Gly Ser Glu Gln Glu Met Ser Arg His Val 
            100                 105                 110         


Glu His Cys Leu Ser Lys Arg Glu Gly Ser Cys Met Ala Glu Asp Asp 
        115                 120                 125             


Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg Phe Glu Glu Tyr Glu 
    130                 135                 140                 


Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr Leu Leu Glu Gly Gly 
145                 150                 155                 160 


Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly Lys Glu Asn Pro Asp 
                165                 170                 175     


Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp Thr Leu Glu Tyr Gly 
            180                 185                 190         


Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro Cys Thr Gly Glu Glu 
        195                 200                 205             


Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg Gly Ala Val Leu Asn 
    210                 215                 220                 


Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu Phe Ser Lys Trp Ala 
225                 230                 235                 240 


Ser Asp Glu Met Pro Ser Thr Ser Asn Gly Glu Ser Ser Lys Gln Glu 
                245                 250                 255     


Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile Glu Lys Ile Thr Glu 
            260                 265                 270         


Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys Ala Arg Val Arg Glu 
        275                 280                 285             


Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr Lys Cys Leu Ile Cys 
    290                 295                 300                 


Met Asp Ser Tyr Ser Met Pro Leu Thr Ser Ile Gln Cys Trp His Val 
305                 310                 315                 320 


His Cys Glu Glu Cys Trp Leu Arg Thr Leu Gly Ala Lys Lys Leu Cys 
                325                 330                 335     


Pro Gln Cys Asn Thr Ile Thr Ala Pro Gly Asp Leu Arg Arg Ile Tyr 
            340                 345                 350         


Leu 
    


<210> 7867
<211> 593
<212> PRT
<213> Homo sapiens

<400> 7867
Met Glu Lys Leu Ser Ala Leu Gln Glu Gln Lys Gly Glu Leu Arg Lys 
1               5                   10                  15      


Arg Leu Ser Tyr Thr Thr His Lys Leu Glu Lys Leu Glu Thr Glu Phe 
            20                  25                  30          


Asp Ser Thr Arg His Tyr Leu Glu Ile Glu Leu Arg Arg Ala Gln Glu 
        35                  40                  45              


Glu Leu Glu Lys Val Thr Glu Lys Leu Arg Arg Ile Gln Ser Asn Tyr 
    50                  55                  60                  


Met Ala Leu Gln Arg Ile Asn Gln Glu Leu Glu Asp Lys Leu Tyr Arg 
65                  70                  75                  80  


Met Gly Gln His Tyr Glu Glu Glu Lys Arg Ala Leu Ser His Glu Ile 
                85                  90                  95      


Val Ala Leu Asn Ser His Leu Leu Glu Ala Lys Val Thr Ile Asp Lys 
            100                 105                 110         


Leu Ser Glu Asp Asn Glu Leu Tyr Arg Lys Asp Cys Asn Leu Ala Ala 
        115                 120                 125             


Gln Leu Leu Gln Cys Ser Gln Thr Tyr Gly Arg Val His Lys Val Ser 
    130                 135                 140                 


Glu Leu Pro Ser Asp Phe Gln Glu Arg Val Ser Leu His Met Glu Lys 
145                 150                 155                 160 


His Gly Cys Ser Leu Pro Ser Pro Leu Cys His Pro Ala Tyr Ala Asp 
                165                 170                 175     


Ser Val Pro Thr Cys Val Ile Ala Lys Val Leu Glu Lys Pro Asp Pro 
            180                 185                 190         


Ala Ser Leu Ser Ser Arg Leu Ser Asp Ala Ser Ala Arg Asp Leu Ala 
        195                 200                 205             


Phe Cys Asp Gly Val Glu Lys Pro Gly Pro Arg Pro Pro Tyr Lys Gly 
    210                 215                 220                 


Asp Ile Tyr Cys Ser Asp Thr Ala Leu Tyr Cys Pro Glu Glu Arg Arg 
225                 230                 235                 240 


Arg Asp Arg Arg Pro Ser Val Asp Ala Pro Val Thr Asp Val Gly Phe 
                245                 250                 255     


Leu Arg Ala Gln Asn Ser Thr Asp Ser Ala Ala Glu Glu Glu Glu Glu 
            260                 265                 270         


Ala Glu Ala Ala Ala Phe Pro Ala Gly Phe Gln His Glu Ala Phe Pro 
        275                 280                 285             


Ser Tyr Ala Gly Ser Leu Pro Thr Ser Ser Ser Tyr Ser Ser Phe Ser 
    290                 295                 300                 


Ala Thr Ser Glu Glu Lys Glu His Ala Gln Ala Ser Thr Leu Thr Ala 
305                 310                 315                 320 


Ser Gln Gln Ala Ile Tyr Leu Asn Ser Arg Asp Glu Leu Phe Asp Arg 
                325                 330                 335     


Lys Pro Pro Ala Thr Thr Tyr Glu Gly Ser Pro Arg Phe Ala Lys Ala 
            340                 345                 350         


Thr Ala Ala Val Ala Ala Pro Leu Glu Ala Glu Val Ala Pro Gly Phe 
        355                 360                 365             


Gly Arg Thr Met Ser Pro Tyr Pro Ala Glu Thr Phe Arg Phe Pro Ala 
    370                 375                 380                 


Ser Pro Gly Pro Gln Gln Ala Leu Met Pro Pro Asn Leu Trp Ser Leu 
385                 390                 395                 400 


Arg Ala Lys Pro Gly Thr Ala Arg Leu Pro Gly Glu Asp Met Arg Gly 
                405                 410                 415     


Gln Trp Arg Pro Leu Ser Val Glu Asp Ile Gly Ala Tyr Ser Tyr Pro 
            420                 425                 430         


Val Ser Ala Ala Gly Arg Ala Ser Pro Cys Ser Phe Ser Glu Arg Tyr 
        435                 440                 445             


Tyr Gly Gly Ala Gly Gly Ser Pro Gly Lys Lys Ala Asp Gly Arg Ala 
    450                 455                 460                 


Ser Pro Leu Tyr Ala Ser Tyr Lys Ala Asp Ser Phe Ser Glu Gly Asp 
465                 470                 475                 480 


Asp Leu Ser Gln Gly His Leu Ala Glu Pro Cys Phe Leu Arg Ala Gly 
                485                 490                 495     


Gly Asp Leu Ser Leu Ser Pro Gly Arg Ser Ala Asp Pro Leu Pro Gly 
            500                 505                 510         


Tyr Ala Pro Ser Glu Gly Gly Asp Gly Asp Arg Leu Gly Val Gln Leu 
        515                 520                 525             


Cys Gly Thr Ala Ser Ser Pro Glu Pro Glu Gln Gly Ser Arg Asp Ser 
    530                 535                 540                 


Leu Glu Pro Ser Ser Met Glu Ala Ser Pro Glu Met His Pro Ala Ala 
545                 550                 555                 560 


Arg Leu Ser Pro Gln Gln Ala Phe Pro Arg Thr Gly Gly Ser Gly Leu 
                565                 570                 575     


Ser Arg Lys Asp Ser Leu Thr Lys Ala Gln Leu Tyr Gly Thr Leu Leu 
            580                 585                 590         


Asn 
    


<210> 7868
<211> 120
<212> PRT
<213> Homo sapiens

<400> 7868
Leu Ala Leu Gln Ile Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn 
1               5                   10                  15      


Ala Leu Lys Pro Glu Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu 
            20                  25                  30          


Gly Lys Leu Val Arg Gly Asp Ala His Glu Cys Phe Val Ser Pro Val 
        35                  40                  45              


Ala Lys Ala Val Ile Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp 
    50                  55                  60                  


Gly Lys Lys Ile Leu Val Val Gly Ala His Gly Ser Leu Glu Ala Ala 
65                  70                  75                  80  


Leu Gln Cys Leu Phe Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln 
                85                  90                  95      


Trp Lys Thr Arg Gln Leu Gln Ser Lys Thr Glu Ser Arg Ser Val Thr 
            100                 105                 110         


Arg Leu Glu Cys Arg Arg Val Ile 
        115                 120 


<210> 7869
<211> 388
<212> PRT
<213> Homo sapiens

<400> 7869
Met Ser Gly Thr Phe Leu Ile Arg Lys Pro Gln Leu Leu Gln Gly Val 
1               5                   10                  15      


Tyr Ala Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Asn Ala Leu 
            20                  25                  30          


Pro Met Met Leu Ala Glu Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln 
        35                  40                  45              


Ser Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg 
    50                  55                  60                  


Val Glu Pro Ser Asp Arg Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr 
65                  70                  75                  80  


Tyr Glu Leu Ala Leu Gln Thr Gly Lys Val Ile Glu Gln Met Gly Lys 
                85                  90                  95      


Phe Tyr Pro Glu Leu Lys Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu 
            100                 105                 110         


Glu Arg Gly Gln Lys Ile Ser Glu Gln Ile Val Ile Gly Thr Pro Gly 
        115                 120                 125             


Thr Val Leu Asp Trp Cys Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ile Lys Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Ala Thr Gln 
145                 150                 155                 160 


Gly His Gln Asp Gln Ser Ile Arg Ile Gln Arg Met Leu Pro Arg Asn 
                165                 170                 175     


Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Lys 
            180                 185                 190         


Phe Ala Gln Lys Val Val Pro Asp Pro Asn Val Ile Lys Leu Lys Arg 
        195                 200                 205             


Glu Glu Glu Thr Leu Asp Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser 
    210                 215                 220                 


Ser Arg Asp Glu Lys Phe Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Gln Ala Met Ile Phe Cys His Thr Arg Lys Thr Ala Ser 
                245                 250                 255     


Trp Leu Ala Ala Glu Leu Ser Lys Glu Gly His Gln Val Ala Leu Leu 
            260                 265                 270         


Ser Gly Glu Met Met Val Glu Gln Arg Ala Ala Val Ile Glu Arg Phe 
        275                 280                 285             


Arg Glu Gly Lys Glu Lys Val Leu Val Thr Thr Asn Val Cys Ala Arg 
    290                 295                 300                 


Gly Ile Asp Val Glu Gln Val Ser Val Val Ile Asn Phe Asp Leu Pro 
305                 310                 315                 320 


Val Asp Lys Asp Gly Asn Pro Asp Asn Glu Thr Tyr Leu His Arg Ile 
                325                 330                 335     


Gly Arg Thr Gly Arg Phe Gly Lys Arg Gly Leu Ala Val Asn Met Val 
            340                 345                 350         


Asp Ser Lys His Ser Met Asn Ile Leu Asn Arg Ile Gln Glu His Phe 
        355                 360                 365             


Asn Lys Lys Ile Glu Arg Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu 
    370                 375                 380                 


Lys Ile Ala Asn 
385             


<210> 7870
<211> 606
<212> PRT
<213> Homo sapiens

<400> 7870
Leu Arg Gln Cys Tyr Asn Tyr Asn Cys Pro Ser Phe Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Arg Ala Thr Ser Asp Glu Val Leu Gln Ser Asp Leu Ser Ala 
            20                  25                  30          


His Tyr Ile Pro Lys Glu Thr Asp Gly Thr Glu Gly Thr Val Glu Ile 
        35                  40                  45              


Glu Thr Val Lys Leu Ala Arg Ser Val Phe Ser Lys Leu His Glu Ile 
    50                  55                  60                  


Cys Cys Ser Trp Val Lys Asp Phe Pro Leu Arg Arg Arg Pro Gln Leu 
65                  70                  75                  80  


Tyr Tyr Glu Thr Ser Ile His Ala Ile Lys Asn Met Arg Lys Leu Phe 
                85                  90                  95      


Tyr Lys His Ile Ser Lys Lys Lys Lys Lys Arg Lys Lys Arg Asp Trp 
            100                 105                 110         


Asp Gln Glu Glu Gln Ala Tyr Phe Ala Val Phe Asp Gly His Gly Gly 
        115                 120                 125             


Val Asp Ala Ala Ile Tyr Ala Ser Ile His Leu His Val Asn Leu Val 
    130                 135                 140                 


Arg Gln Glu Met Phe Pro His Asp Pro Ala Glu Ala Leu Cys Arg Ala 
145                 150                 155                 160 


Phe Arg Val Thr Asp Glu Arg Phe Val Gln Lys Ala Ala Arg Glu Ser 
                165                 170                 175     


Leu Arg Cys Gly Thr Thr Gly Val Val Thr Phe Ile Arg Gly Asn Met 
            180                 185                 190         


Leu His Val Ala Trp Val Gly Asp Ser Gln Val Met Leu Val Arg Lys 
        195                 200                 205             


Gly Gln Ala Val Glu Leu Met Lys Pro His Lys Pro Asp Arg Glu Asp 
    210                 215                 220                 


Glu Lys Gln Arg Ile Glu Ala Leu Gly Gly Cys Val Val Trp Phe Gly 
225                 230                 235                 240 


Ala Trp Arg Val Asn Gly Ser Leu Ser Val Ser Arg Ala Ile Gly Asp 
                245                 250                 255     


Ala Glu His Lys Pro Tyr Ile Cys Gly Asp Ala Asp Ser Ala Ser Thr 
            260                 265                 270         


Val Leu Asp Gly Thr Glu Asp Tyr Leu Ile Leu Ala Cys Asp Gly Phe 
        275                 280                 285             


Tyr Asp Thr Val Asn Pro Asp Glu Ala Val Lys Val Val Ser Asp His 
    290                 295                 300                 


Leu Lys Glu Asn Asn Gly Asp Ser Ser Met Val Ala His Lys Leu Val 
305                 310                 315                 320 


Ala Ser Ala Arg Asp Ala Gly Ser Ser Asp Asn Ile Thr Val Ile Val 
                325                 330                 335     


Val Phe Leu Arg Asp Met Asn Lys Ala Val Asn Val Ser Glu Glu Ser 
            340                 345                 350         


Asp Trp Thr Glu Asn Ser Phe Gln Gly Gly Gln Glu Asp Gly Gly Asp 
        355                 360                 365             


Asp Lys Glu Asn His Gly Glu Cys Lys Arg Pro Trp Pro Gln His Gln 
    370                 375                 380                 


Cys Ser Ala Pro Ala Asp Leu Gly Tyr Asp Gly Arg Val Asp Ser Phe 
385                 390                 395                 400 


Thr Asp Arg Thr Ser Leu Ser Pro Gly Ser Gln Ile Asn Val Leu Glu 
                405                 410                 415     


Asp Pro Gly Tyr Leu Asp Leu Thr Gln Ile Glu Ala Ser Lys Pro His 
            420                 425                 430         


Ser Ala Gln Phe Leu Leu Pro Val Glu Met Phe Gly Pro Gly Ala Pro 
        435                 440                 445             


Lys Lys Ala Asn Leu Ile Asn Glu Leu Met Met Glu Lys Lys Ser Val 
    450                 455                 460                 


Gln Ser Ser Leu Pro Glu Trp Ser Gly Ala Gly Glu Phe Pro Thr Ala 
465                 470                 475                 480 


Phe Asn Leu Gly Ser Thr Gly Glu Gln Ile Tyr Arg Met Gln Ser Leu 
                485                 490                 495     


Ser Pro Val Cys Ser Gly Leu Glu Asn Glu Gln Phe Lys Ser Pro Gly 
            500                 505                 510         


Asn Arg Val Ser Arg Leu Ser His Leu Arg His His Tyr Ser Lys Lys 
        515                 520                 525             


Trp His Arg Phe Arg Phe Asn Pro Lys Phe Tyr Ser Phe Leu Ser Ala 
    530                 535                 540                 


Gln Glu Pro Ser His Lys Ile Gly Thr Ser Leu Ser Ser Leu Thr Gly 
545                 550                 555                 560 


Ser Gly Lys Arg Asn Arg Ile Arg Ser Ser Leu Pro Trp Arg Gln Asn 
                565                 570                 575     


Ser Trp Lys Gly Tyr Ser Glu Asn Met Arg Lys Leu Arg Lys Thr His 
            580                 585                 590         


Asp Ile Pro Cys Pro Asp Leu Pro Trp Ser Tyr Lys Ile Glu 
        595                 600                 605     


<210> 7871
<211> 225
<212> PRT
<213> Homo sapiens

<400> 7871
Met Glu Asn Leu Leu Gln Ala Thr Lys Ser His Val Asp Lys Val Ile 
1               5                   10                  15      


Met Lys Leu Gly Lys Thr Asn Ala Lys Ala Val Ser Glu Met Arg Gln 
            20                  25                  30          


Lys Ile Trp Asn Asn Met Pro Lys Asp His Pro Asp His Glu Leu Ile 
        35                  40                  45              


Asp Pro Phe Pro Val Pro Leu Val Ile Ile Gly Ser Lys Tyr Asp Val 
    50                  55                  60                  


Phe Gln Asp Phe Glu Ser Glu Lys Arg Lys Val Ile Cys Lys Thr Leu 
65                  70                  75                  80  


Arg Phe Val Ala His Tyr Tyr Gly Ala Ser Leu Met Phe Thr Ser Lys 
                85                  90                  95      


Ser Glu Ala Leu Leu Leu Lys Ile Arg Gly Val Ile Asn Gln Leu Ala 
            100                 105                 110         


Phe Gly Ile Asp Lys Ser Lys Ser Ile Cys Val Asp Gln Asn Lys Pro 
        115                 120                 125             


Leu Phe Ile Thr Ala Gly Leu Asp Ser Phe Gly Gln Ile Gly Ser Pro 
    130                 135                 140                 


Pro Val Pro Glu Asn Asp Ile Gly Lys Leu His Ala His Ser Pro Met 
145                 150                 155                 160 


Glu Leu Trp Lys Lys Val Tyr Glu Lys Leu Phe Pro Pro Lys Ser Ile 
                165                 170                 175     


Asn Thr Leu Lys Asp Ile Lys Asp Pro Ala Arg Asp Pro Gln Tyr Ala 
            180                 185                 190         


Glu Asn Glu Val Asp Glu Met Arg Ile Gln Lys Asp Leu Glu Leu Glu 
        195                 200                 205             


Gln Tyr Lys Arg Ser Ser Ser Lys Ser Trp Lys Gln Ile Glu Leu Asp 
    210                 215                 220                 


Ser 
225 


<210> 7872
<211> 206
<212> PRT
<213> Homo sapiens

<400> 7872
Met Gly Phe Ser Asn Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg 
1               5                   10                  15      


Val Ala Glu Pro Gln Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe 
            20                  25                  30          


Glu Glu Leu Leu Ala Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys 
        35                  40                  45              


Glu Leu Phe Glu Gln Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln 
    50                  55                  60                  


Lys Glu Val Glu Lys Val Lys Pro Gln Cys Lys Glu Val His Gln Thr 
65                  70                  75                  80  


Leu Ile Leu Asp Pro Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln 
                85                  90                  95      


Gln His Val Gln Leu Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn 
            100                 105                 110         


Pro Asn Leu Asn Pro Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu 
        115                 120                 125             


Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn 
    130                 135                 140                 


Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met 
145                 150                 155                 160 


Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro 
                165                 170                 175     


His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys 
            180                 185                 190         


Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val Phe Met Tyr 
        195                 200                 205     


<210> 7873
<211> 155
<212> PRT
<213> Homo sapiens

<400> 7873
Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
1               5                   10                  15      


Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly Leu Tyr 
    50                  55                  60                  


Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
            100                 105                 110         


Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
        115                 120                 125             


Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
    130                 135                 140                 


Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg 
145                 150                 155 


<210> 7874
<211> 81
<212> PRT
<213> Homo sapiens

<400> 7874
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu 
    


<210> 7875
<211> 415
<212> PRT
<213> Homo sapiens

<400> 7875
Met Ala Pro Val Gly Val Glu Lys Lys Leu Leu Leu Gly Pro Asn Gly 
1               5                   10                  15      


Pro Ala Val Ala Ala Ala Gly Asp Leu Thr Ser Glu Glu Glu Glu Gly 
            20                  25                  30          


Gln Ser Leu Trp Ser Ser Ile Leu Ser Glu Val Ser Thr Arg Ala Arg 
        35                  40                  45              


Ser Lys Leu Pro Ser Gly Lys Asn Ile Leu Val Phe Gly Glu Asp Gly 
    50                  55                  60                  


Ser Gly Lys Thr Thr Leu Met Thr Lys Leu Gln Gly Ala Glu His Gly 
65                  70                  75                  80  


Lys Lys Gly Arg Gly Leu Glu Tyr Leu Tyr Leu Ser Val His Asp Glu 
                85                  90                  95      


Asp Arg Asp Val Val Lys Asp Phe Gln Asp Tyr Met Glu Pro Glu Glu 
            100                 105                 110         


Gly Cys Gln Gly Ser Pro Gln Arg Arg Gly Pro Leu Thr Ser Gly Ser 
        115                 120                 125             


Asp Glu Glu Asn Val Ala Leu Pro Leu Gly Asp Asn Val Leu Thr His 
    130                 135                 140                 


Asn Leu Gly Ile Pro Val Leu Val Val Cys Thr Lys Cys Asp Ala Val 
145                 150                 155                 160 


Ser Val Leu Glu Lys Glu His Asp Tyr Arg Asp Glu His Leu Asp Phe 
                165                 170                 175     


Ile Gln Ser His Leu Arg Arg Phe Cys Leu Gln Tyr Gly Ala Ala Leu 
            180                 185                 190         


Ile Tyr Thr Ser Val Lys Glu Glu Lys Asn Leu Asp Leu Leu Tyr Lys 
        195                 200                 205             


Tyr Ile Val His Lys Thr Tyr Gly Phe His Phe Thr Thr Pro Ala Leu 
    210                 215                 220                 


Val Val Glu Lys Asp Ala Val Phe Ile Pro Ala Gly Trp Asp Asn Glu 
225                 230                 235                 240 


Lys Lys Ile Ala Ile Leu His Glu Asn Phe Thr Thr Val Lys Pro Glu 
                245                 250                 255     


Asp Ala Tyr Glu Asp Phe Ile Val Lys Pro Pro Val Arg Lys Leu Val 
            260                 265                 270         


His Asp Lys Glu Leu Ala Ala Glu Asp Glu Gln Val Phe Leu Met Lys 
        275                 280                 285             


Gln Gln Ser Leu Leu Ala Lys Gln Pro Ala Thr Pro Thr Arg Ala Ser 
    290                 295                 300                 


Glu Ser Pro Ala Arg Gly Pro Ser Gly Ser Pro Arg Thr Gln Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Ala Ser Val Pro Ser Ser Ser Pro Gly Thr Ser Val Lys 
                325                 330                 335     


Lys Pro Asp Pro Asn Ile Lys Asn Asn Ala Ala Ser Glu Gly Val Leu 
            340                 345                 350         


Ala Ser Phe Phe Asn Ser Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly 
        355                 360                 365             


Ser Pro Gly Ala Gly Gly Val Gln Ser Thr Ala Lys Lys Ser Gly Gln 
    370                 375                 380                 


Lys Thr Val Leu Ser Asn Val Gln Glu Glu Leu Asp Arg Met Thr Arg 
385                 390                 395                 400 


Lys Pro Asp Ser Met Val Thr Asn Ser Ser Thr Glu Asn Glu Ala 
                405                 410                 415 


<210> 7876
<211> 642
<212> PRT
<213> Homo sapiens

<400> 7876
Met Arg Ser Ile Thr Gln Gly Ala Cys Arg Phe Ile Trp Glu Asp Lys 
1               5                   10                  15      


Gly Tyr Ile Ser Gly Asp His Ile Asn Leu Val Ser Ser Ser Leu Ser 
            20                  25                  30          


Ser Phe Pro Ile Leu Gln Arg Ser Ser Glu Glu Lys Ile Leu Tyr Ser 
        35                  40                  45              


Asp Arg Leu Ser Leu Glu Arg Gln Lys Leu Thr Val Cys Pro Ile Ile 
    50                  55                  60                  


Asn Gly Glu Asp His Leu Arg Leu Leu Asn Phe Gln His Asn Phe Ile 
65                  70                  75                  80  


Thr Arg Ile Gln Asn Ile Ser Asn Leu Gln Lys Leu Ile Ser Leu Asp 
                85                  90                  95      


Leu Tyr Asp Asn Gln Ile Glu Glu Ile Ser Gly Leu Ser Thr Leu Arg 
            100                 105                 110         


Cys Leu Arg Val Leu Leu Leu Gly Lys Asn Arg Ile Lys Lys Ile Ser 
        115                 120                 125             


Asn Leu Glu Asn Leu Lys Ser Leu Asp Val Leu Asp Leu His Gly Asn 
    130                 135                 140                 


Gln Ile Thr Lys Ile Glu Asn Ile Asn His Leu Cys Glu Leu Arg Val 
145                 150                 155                 160 


Leu Asn Leu Ala Arg Asn Phe Leu Ser His Val Asp Asn Leu Asn Gly 
                165                 170                 175     


Leu Asp Ser Leu Thr Glu Leu Asn Leu Arg His Asn Gln Ile Thr Phe 
            180                 185                 190         


Val Arg Asp Val Asp Asn Leu Pro Cys Leu Gln His Leu Phe Leu Ser 
        195                 200                 205             


Phe Asn Asn Ile Ser Ser Phe Asp Ser Val Ser Cys Leu Ala Asp Ser 
    210                 215                 220                 


Ser Ser Leu Ser Asp Ile Thr Phe Asp Gly Asn Pro Ile Ala Gln Glu 
225                 230                 235                 240 


Ser Trp Tyr Lys His Thr Val Leu Gln Asn Met Met Gln Leu Arg Gln 
                245                 250                 255     


Leu Asp Met Lys Arg Ile Thr Glu Glu Glu Arg Arg Met Ala Ser Val 
            260                 265                 270         


Leu Ala Lys Lys Glu Glu Glu Lys Lys Arg Glu Ser His Lys Gln Ser 
        275                 280                 285             


Leu Leu Lys Glu Lys Lys Arg Leu Thr Ile Asn Asn Val Ala Arg Gln 
    290                 295                 300                 


Trp Asp Leu Gln Gln Gln Arg Val Ala Asn Ile Ala Thr Asn Glu Asp 
305                 310                 315                 320 


Arg Lys Asp Ser Asp Ser Pro Gln Asp Pro Cys Gln Ile Asp Gly Ser 
                325                 330                 335     


Thr Leu Ser Ala Phe Pro Glu Glu Thr Gly Pro Leu Asp Ser Gly Leu 
            340                 345                 350         


Asn Asn Ala Leu Gln Gly Leu Ser Val Ile Asp Thr Tyr Leu Val Glu 
        355                 360                 365             


Val Asp Gly Asp Thr Leu Ser Leu Tyr Gly Ser Gly Ala Leu Glu Ser 
    370                 375                 380                 


Leu Asp Arg Asn Trp Ser Val Gln Thr Ala Gly Met Ile Thr Thr Val 
385                 390                 395                 400 


Ser Phe Thr Phe Ile Glu Phe Asp Glu Ile Val Gln Val Leu Pro Lys 
                405                 410                 415     


Leu Lys Ile Lys Phe Pro Asn Ser Leu His Leu Lys Phe Lys Glu Thr 
            420                 425                 430         


Asn Leu Val Met Leu Gln Gln Phe Asn Ala Leu Ala Gln Leu Arg Arg 
        435                 440                 445             


Ile Asp Gln Leu Thr Ile Asp Pro Gln Gly Asn Pro Val Val Asn Phe 
    450                 455                 460                 


Thr Leu Trp Lys Tyr Tyr Val Leu Phe Arg Leu Ser His Phe Ser Met 
465                 470                 475                 480 


Gln Lys Ile Asn Gly Thr Glu Val Thr Gln Asn Asp Met Ile Met Ala 
                485                 490                 495     


Glu Arg Leu Phe Gly Ile Leu Ala His Val Ala Ser Ser Glu Leu Pro 
            500                 505                 510         


Gln Tyr Arg Leu Ile Ser Ile Leu Gly Asp Ala Arg Lys Lys Gln Phe 
        515                 520                 525             


Arg Tyr Leu Leu Glu Ser Lys Gly Lys Lys Pro Gly Ile Ile Asn Glu 
    530                 535                 540                 


Glu Asn Asn Asp Ser Lys Arg Leu Val Gly Glu Asn Thr Asn Arg Ala 
545                 550                 555                 560 


Thr Leu Asn Tyr Thr Thr Arg Asp Phe Tyr Asn Glu Lys Leu Glu Glu 
                565                 570                 575     


Ile Lys Glu Lys Lys Lys Phe Cys Lys Thr Tyr Ile Glu Asp Leu Val 
            580                 585                 590         


Lys Glu Ala Thr Glu Ile Asn Met Lys Asn Glu Ala Leu Gln Lys Leu 
        595                 600                 605             


Trp Pro Gln Met Phe Ile Glu Leu Val Arg Asp Ala Val Ile Glu Ile 
    610                 615                 620                 


Arg Asn Lys Asn Ser Tyr Met Lys Leu Cys Leu Gln Gln Ile Thr Asp 
625                 630                 635                 640 


Gln Lys 
        


<210> 7877
<211> 143
<212> PRT
<213> Homo sapiens

<400> 7877
Arg Leu Gly Arg Tyr Glu Val Glu Lys Arg Cys Ala Val Glu Lys Glu 
1               5                   10                  15      


Asp Tyr Asp Leu Ala Lys Glu Lys Lys Gln Gln Met Glu Gln Tyr Arg 
            20                  25                  30          


Ala Glu Val Tyr Glu Gln Leu Glu Leu His Ser Leu Leu Asp Ala Glu 
        35                  40                  45              


Leu His Ser Ala Val Asp Pro Leu Leu Pro Ala Thr Asp Pro His Pro 
    50                  55                  60                  


Lys Ile Asn Ala Glu Ser Leu Pro Tyr Asp Glu Arg Pro Leu Pro Ala 
65                  70                  75                  80  


Ile Arg Lys His Tyr Gly Glu Ala Val Val Glu Pro Glu Met Ser Asn 
                85                  90                  95      


Ala Asp Ile Ser Asp Ala Arg Arg Gly Gly Met Leu Gly Glu Pro Glu 
            100                 105                 110         


Pro Leu Thr Glu Lys Ala Leu Arg Glu Ala Ser Ser Ala Ile Asp Val 
        115                 120                 125             


Leu Gly Glu Thr Leu Val Ala Glu Ala Tyr Cys Lys Thr Trp Ser 
    130                 135                 140             


<210> 7878
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7878
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 7879
<211> 183
<212> PRT
<213> Homo sapiens

<400> 7879
Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Ser Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn 
    50                  55                  60                  


Leu Glu His Pro Glu Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met 
65                  70                  75                  80  


Arg Val Trp Ser Arg Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu 
                85                  90                  95      


Ala Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu 
            100                 105                 110         


Leu Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr 
        115                 120                 125             


Thr Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val 
    130                 135                 140                 


Ala His Val Asp Gly Gln Thr His Met Leu Phe Gly Ser Asp Arg Met 
145                 150                 155                 160 


Glu Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro 
                165                 170                 175     


Pro Ala Val Asn Ala Arg Leu 
            180             


<210> 7880
<211> 101
<212> PRT
<213> Homo sapiens

<400> 7880
Glu Gly Thr Ser Gly Lys Thr Ala Leu His Leu Ala Val Glu Thr Gln 
1               5                   10                  15      


Glu Arg Gly Leu Val Gln Phe Leu Leu Gln Ala Gly Ala Gln Val Asp 
            20                  25                  30          


Ala Arg Met Leu Asn Gly Cys Thr Pro Leu His Leu Ala Ala Gly Arg 
        35                  40                  45              


Gly Leu Met Gly Ile Ser Ser Thr Leu Cys Lys Ala Gly Ala Asp Ser 
    50                  55                  60                  


Leu Leu Arg Asn Val Glu Asp Glu Thr Pro Gln Asp Leu Thr Glu Glu 
65                  70                  75                  80  


Ser Leu Val Leu Leu Pro Phe Asp Asp Leu Lys Ile Ser Gly Lys Leu 
                85                  90                  95      


Leu Leu Cys Thr Asp 
            100     


<210> 7881
<211> 4861
<212> PRT
<213> Homo sapiens

<400> 7881
Met Ala Thr Met Ile Pro Pro Val Lys Leu Lys Trp Leu Glu His Leu 
1               5                   10                  15      


Asn Ser Ser Trp Ile Thr Glu Asp Ser Glu Ser Ile Ala Thr Arg Glu 
            20                  25                  30          


Gly Val Ala Val Leu Tyr Ser Lys Leu Val Ser Asn Lys Glu Val Val 
        35                  40                  45              


Pro Leu Pro Gln Gln Val Leu Cys Leu Lys Gly Pro Gln Leu Pro Asp 
    50                  55                  60                  


Phe Glu Arg Glu Ser Leu Ser Ser Asp Glu Gln Asp His Tyr Leu Asp 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Gln Leu Ala Leu Ala Lys Met Val Cys Ser Asp 
                85                  90                  95      


Ser Pro Phe Ala Gly Ala Leu Arg Lys Arg Leu Leu Val Leu Gln Arg 
            100                 105                 110         


Val Phe Tyr Ala Leu Ser Asn Lys Tyr His Asp Lys Gly Lys Val Lys 
        115                 120                 125             


Gln Gln Gln His Ser Pro Glu Ser Ser Ser Gly Ser Ala Asp Val His 
    130                 135                 140                 


Ser Val Ser Glu Arg Pro Arg Ser Ser Thr Asp Ala Leu Ile Glu Met 
145                 150                 155                 160 


Gly Val Arg Thr Gly Leu Ser Leu Leu Phe Ala Leu Leu Arg Gln Ser 
                165                 170                 175     


Trp Met Met Pro Val Ser Gly Pro Gly Leu Ser Leu Cys Asn Asp Val 
            180                 185                 190         


Ile His Thr Ala Ile Glu Val Val Ser Ser Leu Pro Pro Leu Ser Leu 
        195                 200                 205             


Ala Asn Glu Ser Lys Ile Pro Pro Met Gly Leu Asp Cys Leu Ser Gln 
    210                 215                 220                 


Val Thr Thr Phe Leu Lys Gly Val Thr Ile Pro Asn Ser Gly Ala Asp 
225                 230                 235                 240 


Thr Leu Gly Arg Arg Leu Ala Ser Glu Leu Leu Leu Gly Leu Ala Ala 
                245                 250                 255     


Gln Arg Gly Ser Leu Arg Tyr Leu Leu Glu Trp Ile Glu Met Ala Leu 
            260                 265                 270         


Gly Ala Ser Ala Val Val His Thr Met Glu Lys Gly Lys Leu Leu Ser 
        275                 280                 285             


Ser Gln Glu Gly Met Ile Ser Phe Asp Cys Phe Met Thr Ile Leu Met 
    290                 295                 300                 


Gln Met Arg Arg Ser Leu Gly Ser Ser Ala Asp Arg Ser Gln Trp Arg 
305                 310                 315                 320 


Glu Pro Thr Arg Thr Ser Asp Gly Leu Cys Ser Leu Tyr Glu Ala Ala 
                325                 330                 335     


Leu Cys Leu Phe Glu Glu Val Cys Arg Met Ala Ser Asp Tyr Ser Arg 
            340                 345                 350         


Thr Cys Ala Ser Pro Asp Ser Ile Gln Thr Gly Asp Ala Pro Ile Val 
        355                 360                 365             


Ser Glu Thr Cys Glu Val Tyr Val Trp Gly Ser Asn Ser Ser His Gln 
    370                 375                 380                 


Leu Val Glu Gly Thr Gln Glu Lys Ile Leu Gln Pro Lys Leu Ala Pro 
385                 390                 395                 400 


Ser Phe Ser Asp Ala Gln Thr Ile Glu Ala Gly Gln Tyr Cys Thr Phe 
                405                 410                 415     


Val Ile Ser Thr Asp Gly Ser Val Arg Ala Cys Gly Lys Gly Ser Tyr 
            420                 425                 430         


Gly Arg Leu Gly Leu Gly Asp Ser Asn Asn Gln Ser Thr Leu Lys Lys 
        435                 440                 445             


Leu Thr Phe Glu Pro His Arg Ser Ile Lys Lys Val Ser Ser Ser Lys 
    450                 455                 460                 


Gly Ser Asp Gly His Thr Leu Ala Phe Thr Thr Glu Gly Glu Val Phe 
465                 470                 475                 480 


Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly His Gly Asn Ser Ser 
                485                 490                 495     


Thr Gln Lys Tyr Pro Lys Leu Ile Gln Gly Pro Leu Gln Gly Lys Val 
            500                 505                 510         


Val Val Cys Val Ser Ala Gly Tyr Arg His Ser Ala Ala Val Thr Glu 
        515                 520                 525             


Asp Gly Glu Leu Tyr Thr Trp Gly Glu Gly Asp Phe Gly Arg Leu Gly 
    530                 535                 540                 


His Gly Asp Ser Asn Ser Arg Asn Ile Pro Thr Leu Val Lys Asp Ile 
545                 550                 555                 560 


Ser Asn Val Gly Glu Val Ser Cys Gly Ser Ser His Thr Ile Ala Leu 
                565                 570                 575     


Ser Lys Asp Gly Arg Thr Val Trp Ser Phe Gly Gly Gly Asp Asn Gly 
            580                 585                 590         


Lys Leu Gly His Gly Asp Thr Asn Arg Val Tyr Lys Pro Lys Val Ile 
        595                 600                 605             


Glu Ala Leu Gln Gly Met Phe Ile Arg Lys Val Cys Ala Gly Ser Gln 
    610                 615                 620                 


Ser Ser Leu Ala Leu Thr Ser Thr Gly Gln Val Tyr Ala Trp Gly Cys 
625                 630                 635                 640 


Gly Ala Cys Leu Gly Cys Gly Ser Ser Glu Ala Thr Ala Leu Arg Pro 
                645                 650                 655     


Lys Leu Ile Glu Glu Leu Ala Ala Thr Arg Ile Val Asp Val Ser Ile 
            660                 665                 670         


Gly Asp Ser His Cys Leu Ala Leu Ser His Asp Asn Glu Val Tyr Ala 
        675                 680                 685             


Trp Gly Asn Asn Ser Met Gly Gln Cys Gly Gln Gly Asn Ser Thr Gly 
    690                 695                 700                 


Pro Ile Thr Lys Pro Lys Lys Val Ser Gly Leu Asp Gly Ile Ala Ile 
705                 710                 715                 720 


Gln Gln Ile Ser Ala Gly Thr Ser His Ser Leu Ala Trp Thr Ala Leu 
                725                 730                 735     


Pro Arg Asp Arg Gln Val Val Ala Trp His Arg Pro Tyr Cys Val Asp 
            740                 745                 750         


Leu Glu Glu Ser Thr Phe Ser His Leu Arg Ser Phe Leu Glu Arg Tyr 
        755                 760                 765             


Cys Asp Lys Ile Asn Ser Glu Ile Pro Pro Leu Pro Phe Pro Ser Ser 
    770                 775                 780                 


Arg Glu His His Ser Phe Leu Lys Leu Cys Leu Lys Leu Leu Ser Asn 
785                 790                 795                 800 


His Leu Ala Leu Ala Leu Ala Gly Gly Val Ala Thr Ser Ile Leu Gly 
                805                 810                 815     


Arg Gln Ala Gly Pro Leu Arg Asn Leu Leu Phe Arg Leu Met Asp Ser 
            820                 825                 830         


Thr Val Pro Asp Glu Ile Gln Glu Val Val Ile Glu Thr Leu Ser Val 
        835                 840                 845             


Gly Ala Thr Met Leu Leu Pro Pro Leu Arg Glu Arg Met Glu Leu Leu 
    850                 855                 860                 


His Ser Leu Leu Pro Gln Gly Pro Asp Arg Trp Glu Ser Leu Ser Lys 
865                 870                 875                 880 


Gly Gln Arg Met Gln Leu Asp Ile Ile Leu Thr Ser Leu Gln Asp His 
                885                 890                 895     


Thr His Val Ala Ser Leu Leu Gly Tyr Ser Ser Pro Ser Asp Ala Ala 
            900                 905                 910         


Asp Leu Ser Ser Val Cys Thr Gly Tyr Gly Asn Leu Ser Asp Gln Pro 
        915                 920                 925             


Tyr Gly Thr Gln Ser Cys His Pro Asp Thr His Leu Ala Glu Ile Leu 
    930                 935                 940                 


Met Lys Thr Leu Leu Arg Asn Leu Gly Phe Tyr Thr Asp Gln Ala Phe 
945                 950                 955                 960 


Gly Glu Leu Glu Lys Asn Ser Asp Lys Phe Leu Leu Gly Thr Ser Ser 
                965                 970                 975     


Ser Glu Asn Ser Gln Pro Ala His Leu His Glu Leu Leu Cys Ser Leu 
            980                 985                 990         


Gln Lys Gln Leu Leu Ala Phe Cys  His Ile Asn Asn Ile  Ser Glu Asn 
        995                 1000                 1005             


Ser Ser  Ser Val Ala Leu Leu  His Lys His Leu Gln  Leu Leu Leu 
    1010                 1015                 1020             


Pro His  Ala Thr Asp Ile Tyr  Ser Arg Ser Ala Asn  Leu Leu Lys 
    1025                 1030                 1035             


Glu Ser  Pro Trp Asn Gly Ser  Val Gly Glu Lys Leu  Arg Asp Val 
    1040                 1045                 1050             


Ile Tyr  Val Ser Ala Ala Gly  Ser Met Leu Cys Gln  Ile Val Asn 
    1055                 1060                 1065             


Ser Leu  Leu Leu Leu Pro Val  Ser Val Ala Arg Pro  Leu Leu Ser 
    1070                 1075                 1080             


Tyr Leu  Leu Asp Leu Leu Pro  Pro Leu Asp Cys Leu  Asn Arg Leu 
    1085                 1090                 1095             


Leu Pro  Ala Ala Asp Leu Leu  Glu Asp Gln Glu Leu  Gln Trp Pro 
    1100                 1105                 1110             


Leu His  Gly Gly Pro Glu Leu  Ile Asp Pro Ala Gly  Leu Pro Leu 
    1115                 1120                 1125             


Pro Gln  Pro Ala Gln Ser Trp  Val Trp Leu Val Asp  Leu Glu Arg 
    1130                 1135                 1140             


Thr Ile  Ala Leu Leu Ile Gly  Arg Cys Leu Gly Gly  Met Leu Gln 
    1145                 1150                 1155             


Gly Ser  Pro Val Ser Pro Glu  Glu Gln Asp Thr Ala  Tyr Trp Met 
    1160                 1165                 1170             


Lys Thr  Pro Leu Phe Ser Asp  Gly Val Glu Met Asp  Thr Pro Gln 
    1175                 1180                 1185             


Leu Asp  Lys Cys Met Ser Cys  Leu Leu Glu Val Ala  Leu Ser Gly 
    1190                 1195                 1200             


Asn Glu  Glu Gln Lys Pro Phe  Asp Tyr Lys Leu Arg  Pro Glu Ile 
    1205                 1210                 1215             


Ala Val  Tyr Val Asp Leu Ala  Leu Gly Cys Ser Lys  Glu Pro Ala 
    1220                 1225                 1230             


Arg Ser  Leu Trp Ile Ser Met  Gln Asp Tyr Ala Val  Ser Lys Asp 
    1235                 1240                 1245             


Trp Asp  Ser Ala Thr Leu Ser  Asn Glu Ser Leu Leu  Asp Thr Val 
    1250                 1255                 1260             


Ser Arg  Phe Val Leu Ala Ala  Leu Leu Lys His Thr  Asn Leu Leu 
    1265                 1270                 1275             


Ser Gln  Ala Cys Gly Glu Ser  Arg Tyr Gln Pro Gly  Lys His Leu 
    1280                 1285                 1290             


Ser Glu  Val Tyr Arg Cys Val  Tyr Lys Val Arg Ser  Arg Leu Leu 
    1295                 1300                 1305             


Ala Cys  Lys Asn Leu Glu Leu  Ile Gln Thr Arg Ser  Ser Ser Arg 
    1310                 1315                 1320             


Asp Arg  Trp Ile Ser Glu Asn  Gln Asp Ser Ala Asp  Val Asp Pro 
    1325                 1330                 1335             


Gln Glu  His Ser Phe Thr Arg  Thr Ile Asp Glu Glu  Ala Glu Met 
    1340                 1345                 1350             


Glu Glu  Gln Ala Glu Arg Asp  Arg Glu Glu Gly His  Pro Glu Pro 
    1355                 1360                 1365             


Glu Asp  Glu Glu Glu Glu Arg  Glu His Glu Val Met  Thr Ala Gly 
    1370                 1375                 1380             


Lys Ile  Phe Gln Cys Phe Leu  Ser Ala Arg Glu Val  Ala Arg Ser 
    1385                 1390                 1395             


Arg Asp  Arg Asp Arg Met Asn  Ser Gly Ala Gly Ser  Gly Ala Arg 
    1400                 1405                 1410             


Ala Asp  Asp Pro Pro Pro Gln  Ser Gln Gln Glu Arg  Arg Val Ser 
    1415                 1420                 1425             


Thr Asp  Leu Pro Glu Gly Gln  Asp Val Tyr Thr Ala  Ala Cys Asn 
    1430                 1435                 1440             


Ser Val  Ile His Arg Cys Ala  Leu Leu Ile Leu Gly  Val Ser Pro 
    1445                 1450                 1455             


Val Ile  Asp Glu Leu Gln Lys  Arg Arg Glu Glu Gly  Gln Leu Gln 
    1460                 1465                 1470             


Gln Pro  Ser Thr Ser Ala Ser  Glu Gly Gly Gly Leu  Met Thr Arg 
    1475                 1480                 1485             


Ser Glu  Ser Leu Thr Ala Glu  Ser Arg Leu Val His  Thr Ser Pro 
    1490                 1495                 1500             


Asn Tyr  Arg Leu Ile Lys Ser  Arg Ser Glu Ser Asp  Leu Ser Gln 
    1505                 1510                 1515             


Pro Glu  Ser Asp Glu Glu Gly  Tyr Ala Leu Ser Gly  Arg Arg Asn 
    1520                 1525                 1530             


Val Asp  Leu Asp Leu Ala Ala  Ser His Arg Lys Arg  Gly Pro Met 
    1535                 1540                 1545             


His Ser  Gln Leu Glu Ser Leu  Ser Asp Ser Trp Ala  Arg Leu Lys 
    1550                 1555                 1560             


His Ser  Arg Asp Trp Leu Cys  Asn Ser Ser Tyr Ser  Phe Glu Ser 
    1565                 1570                 1575             


Asp Phe  Asp Leu Thr Lys Ser  Leu Gly Val His Thr  Leu Ile Glu 
    1580                 1585                 1590             


Asn Val  Val Ser Phe Val Ser  Gly Asp Val Gly Asn  Ala Pro Gly 
    1595                 1600                 1605             


Phe Lys  Glu Pro Glu Glu Ser  Met Ser Thr Ser Pro  Gln Ala Ser 
    1610                 1615                 1620             


Ile Ile  Ala Met Glu Gln Gln  Gln Leu Arg Ala Glu  Leu Arg Leu 
    1625                 1630                 1635             


Glu Ala  Leu His Gln Ile Leu  Val Leu Leu Ser Gly  Met Glu Glu 
    1640                 1645                 1650             


Lys Gly  Ser Ile Ser Leu Ala  Gly Ser Arg Leu Ser  Ser Gly Phe 
    1655                 1660                 1665             


Gln Ser  Ser Thr Leu Leu Thr  Ser Val Arg Leu Gln  Phe Leu Ala 
    1670                 1675                 1680             


Gly Cys  Phe Gly Leu Gly Thr  Val Gly His Thr Gly  Gly Lys Gly 
    1685                 1690                 1695             


Glu Ser  Gly Arg Leu His His  Tyr Gln Asp Gly Ile  Arg Ala Ala 
    1700                 1705                 1710             


Lys Arg  Asn Ile Gln Ile Glu  Ile Gln Val Ala Val  His Lys Ile 
    1715                 1720                 1725             


Tyr Gln  Gln Leu Ser Ala Thr  Leu Glu Arg Ala Leu  Gln Ala Asn 
    1730                 1735                 1740             


Lys His  His Ile Glu Ala Gln  Gln Arg Leu Leu Leu  Val Thr Val 
    1745                 1750                 1755             


Phe Ala  Leu Ser Val His Tyr  Gln Pro Val Asp Val  Ser Leu Ala 
    1760                 1765                 1770             


Ile Ser  Thr Gly Leu Leu Asn  Val Leu Ser Gln Leu  Cys Gly Thr 
    1775                 1780                 1785             


Asp Thr  Met Leu Gly Gln Pro  Leu Gln Leu Leu Pro  Lys Thr Gly 
    1790                 1795                 1800             


Val Ser  Gln Leu Ser Thr Ala  Leu Lys Val Ala Ser  Thr Arg Leu 
    1805                 1810                 1815             


Leu Gln  Ile Leu Ala Ile Thr  Thr Gly Thr Tyr Ala  Asp Lys Leu 
    1820                 1825                 1830             


Ser Pro  Lys Val Val Gln Ser  Leu Leu Asp Leu Leu  Cys Ser Gln 
    1835                 1840                 1845             


Leu Lys  Asn Leu Leu Ser Gln  Thr Gly Val Leu His  Met Ala Ser 
    1850                 1855                 1860             


Phe Gly  Glu Gly Glu Gln Glu  Asp Gly Glu Glu Glu  Glu Lys Lys 
    1865                 1870                 1875             


Val Asp  Ser Ser Gly Glu Thr  Glu Lys Lys Asp Phe  Arg Ala Ala 
    1880                 1885                 1890             


Leu Arg  Lys Gln His Ala Ala  Glu Leu His Leu Gly  Asp Phe Leu 
    1895                 1900                 1905             


Val Phe  Leu Arg Arg Val Val  Ser Ser Lys Ala Ile  Gln Ser Lys 
    1910                 1915                 1920             


Met Ala  Ser Pro Lys Trp Thr  Glu Val Leu Leu Asn  Ile Ala Ser 
    1925                 1930                 1935             


Gln Lys  Cys Ser Ser Gly Ile  Pro Leu Val Gly Asn  Leu Arg Thr 
    1940                 1945                 1950             


Arg Leu  Leu Ala Leu His Val  Leu Glu Ala Val Leu  Pro Ala Cys 
    1955                 1960                 1965             


Glu Ser  Gly Val Glu Asp Asp  Gln Met Ala Gln Ile  Val Glu Arg 
    1970                 1975                 1980             


Leu Phe  Ser Leu Leu Ser Asp  Cys Met Trp Glu Thr  Pro Ile Ala 
    1985                 1990                 1995             


Gln Ala  Lys His Ala Ile Gln  Ile Lys Glu Lys Glu  Gln Glu Ile 
    2000                 2005                 2010             


Lys Leu  Gln Lys Gln Gly Glu  Leu Glu Glu Glu Asp  Glu Asn Leu 
    2015                 2020                 2025             


Pro Ile  Gln Glu Val Ser Phe  Asp Pro Glu Lys Ala  Gln Cys Cys 
    2030                 2035                 2040             


Leu Val  Glu Asn Gly Gln Ile  Leu Thr His Gly Ser  Gly Gly Lys 
    2045                 2050                 2055             


Gly Tyr  Gly Leu Ala Ser Thr  Gly Val Thr Ser Gly  Cys Tyr Gln 
    2060                 2065                 2070             


Trp Lys  Phe Tyr Ile Val Lys  Glu Asn Arg Gly Asn  Glu Gly Thr 
    2075                 2080                 2085             


Cys Val  Gly Val Ser Arg Trp  Pro Val His Asp Phe  Asn His Arg 
    2090                 2095                 2100             


Thr Thr  Ser Asp Met Trp Leu  Tyr Arg Ala Tyr Ser  Gly Asn Leu 
    2105                 2110                 2115             


Tyr His  Asn Gly Glu Gln Thr  Leu Thr Leu Ser Ser  Phe Thr Gln 
    2120                 2125                 2130             


Gly Asp  Phe Ile Thr Cys Val  Leu Asp Met Glu Ala  Arg Thr Ile 
    2135                 2140                 2145             


Ser Phe  Gly Lys Asn Gly Glu  Glu Pro Lys Leu Ala  Phe Glu Asp 
    2150                 2155                 2160             


Val Asp  Ala Ala Glu Leu Tyr  Pro Cys Val Met Phe  Tyr Ser Ser 
    2165                 2170                 2175             


Asn Pro  Gly Glu Lys Val Lys  Ile Cys Asp Met Gln  Met Arg Gly 
    2180                 2185                 2190             


Thr Pro  Arg Asp Leu Leu Pro  Gly Asp Pro Ile Cys  Ser Pro Val 
    2195                 2200                 2205             


Ala Ala  Val Leu Ala Glu Ala  Thr Ile Gln Leu Ile  Arg Ile Leu 
    2210                 2215                 2220             


His Arg  Thr Asp Arg Trp Thr  Tyr Cys Ile Asn Lys  Lys Met Met 
    2225                 2230                 2235             


Glu Arg  Leu His Lys Ile Lys  Ile Cys Ile Lys Glu  Ser Gly Gln 
    2240                 2245                 2250             


Lys Leu  Lys Lys Ser Arg Ser  Val Gln Ser Arg Glu  Glu Asn Glu 
    2255                 2260                 2265             


Met Arg  Glu Glu Lys Glu Ser  Lys Glu Glu Glu Lys  Gly Lys His 
    2270                 2275                 2280             


Thr Arg  His Gly Leu Ala Asp  Leu Ser Glu Leu Gln  Leu Arg Thr 
    2285                 2290                 2295             


Leu Cys  Ile Glu Val Trp Pro  Val Leu Ala Val Ile  Gly Gly Val 
    2300                 2305                 2310             


Asp Ala  Gly Leu Arg Val Gly  Gly Arg Cys Val His  Lys Gln Thr 
    2315                 2320                 2325             


Gly Arg  His Ala Thr Leu Leu  Gly Val Val Lys Glu  Gly Ser Thr 
    2330                 2335                 2340             


Ser Ala  Lys Val Gln Trp Asp  Glu Ala Glu Ile Thr  Ile Ser Phe 
    2345                 2350                 2355             


Pro Thr  Phe Trp Ser Pro Ser  Asp Thr Pro Leu Tyr  Asn Leu Glu 
    2360                 2365                 2370             


Pro Cys  Glu Pro Leu Pro Phe  Asp Val Ala Arg Phe  Arg Gly Leu 
    2375                 2380                 2385             


Thr Ala  Ser Val Leu Leu Asp  Leu Thr Tyr Leu Thr  Gly Val His 
    2390                 2395                 2400             


Glu Asp  Met Gly Lys Gln Ser  Thr Lys Arg His Glu  Lys Lys His 
    2405                 2410                 2415             


Arg His  Glu Ser Glu Glu Lys  Gly Asp Val Glu Gln  Lys Pro Glu 
    2420                 2425                 2430             


Ser Glu  Ser Ala Leu Asp Met  Arg Thr Gly Leu Thr  Ser Asp Asp 
    2435                 2440                 2445             


Val Lys  Ser Gln Ser Thr Thr  Ser Ser Lys Ser Glu  Asn Glu Ile 
    2450                 2455                 2460             


Ala Ser  Phe Ser Leu Asp Pro  Thr Leu Pro Ser Val  Glu Ser Gln 
    2465                 2470                 2475             


His Gln  Ile Thr Glu Gly Lys  Arg Lys Asn His Glu  His Met Ser 
    2480                 2485                 2490             


Lys Asn  His Asp Val Ala Gln  Ser Glu Ile Arg Ala  Val Gln Leu 
    2495                 2500                 2505             


Ser Tyr  Leu Tyr Leu Gly Ala  Met Lys Ser Leu Ser  Ala Leu Leu 
    2510                 2515                 2520             


Gly Cys  Ser Lys Tyr Ala Glu  Leu Leu Leu Ile Pro  Lys Val Leu 
    2525                 2530                 2535             


Ala Glu  Asn Gly His Asn Ser  Asp Cys Ala Ser Ser  Pro Val Val 
    2540                 2545                 2550             


His Glu  Asp Val Glu Met Arg  Ala Ala Leu Gln Phe  Leu Met Arg 
    2555                 2560                 2565             


His Met  Val Lys Arg Ala Val  Met Arg Ser Pro Ile  Lys Arg Ala 
    2570                 2575                 2580             


Leu Gly  Leu Ala Asp Leu Glu  Arg Ala Gln Ala Met  Ile Tyr Lys 
    2585                 2590                 2595             


Leu Val  Val His Gly Leu Leu  Glu Asp Gln Phe Gly  Gly Lys Ile 
    2600                 2605                 2610             


Lys Gln  Glu Ile Asp Gln Gln  Ala Glu Glu Ser Asp  Pro Ala Gln 
    2615                 2620                 2625             


Gln Ala  Gln Thr Pro Val Thr  Thr Ser Pro Ser Ala  Ser Ser Thr 
    2630                 2635                 2640             


Thr Ser  Phe Met Ser Ser Ser  Leu Glu Asp Thr Thr  Thr Ala Thr 
    2645                 2650                 2655             


Thr Pro  Val Thr Asp Thr Glu  Thr Val Pro Ala Ser  Glu Ser Pro 
    2660                 2665                 2670             


Gly Val  Met Pro Leu Ser Leu  Leu Arg Gln Met Phe  Ser Ser Tyr 
    2675                 2680                 2685             


Pro Thr  Thr Thr Val Leu Pro  Thr Arg Arg Ala Gln  Thr Pro Pro 
    2690                 2695                 2700             


Ile Ser  Ser Leu Pro Thr Ser  Pro Ser Asp Glu Val  Gly Arg Arg 
    2705                 2710                 2715             


Gln Ser  Leu Thr Ser Pro Asp  Ser Gln Ser Ala Arg  Pro Ala Asn 
    2720                 2725                 2730             


Arg Thr  Ala Leu Ser Asp Pro  Ser Ser Arg Leu Ser  Thr Ser Pro 
    2735                 2740                 2745             


Pro Pro  Pro Ala Ile Ala Val  Pro Leu Leu Glu Met  Gly Phe Ser 
    2750                 2755                 2760             


Leu Arg  Gln Ile Ala Lys Ala  Met Glu Ala Thr Gly  Ala Arg Gly 
    2765                 2770                 2775             


Glu Ala  Asp Ala Gln Asn Ile  Thr Val Leu Ala Met  Trp Met Ile 
    2780                 2785                 2790             


Glu His  Pro Gly His Glu Asp  Glu Glu Glu Pro Gln  Ser Gly Ser 
    2795                 2800                 2805             


Thr Ala  Asp Ser Arg Pro Gly  Ala Ala Val Leu Gly  Ser Gly Gly 
    2810                 2815                 2820             


Lys Ser  Asn Asp Pro Cys Tyr  Leu Gln Ser Pro Gly  Asp Ile Pro 
    2825                 2830                 2835             


Ser Ala  Asp Ala Ala Glu Met  Glu Glu Gly Phe Ser  Glu Ser Pro 
    2840                 2845                 2850             


Asp Asn  Leu Asp His Thr Glu  Asn Ala Ala Ser Gly  Ser Gly Pro 
    2855                 2860                 2865             


Ser Ala  Arg Gly Arg Ser Ala  Val Thr Arg Arg His  Lys Phe Asp 
    2870                 2875                 2880             


Leu Ala  Ala Arg Thr Leu Leu  Ala Arg Ala Ala Gly  Leu Tyr Arg 
    2885                 2890                 2895             


Ser Val  Gln Ala His Arg Asn  Gln Ser Arg Arg Glu  Gly Ile Ser 
    2900                 2905                 2910             


Leu Gln  Gln Asp Pro Gly Ala  Leu Tyr Asp Phe Asn  Leu Asp Glu 
    2915                 2920                 2925             


Glu Leu  Glu Ile Asp Leu Asp  Asp Glu Ala Met Glu  Ala Met Phe 
    2930                 2935                 2940             


Gly Gln  Asp Leu Thr Ser Asp  Asn Asp Ile Leu Gly  Met Trp Ile 
    2945                 2950                 2955             


Pro Glu  Val Leu Asp Trp Pro  Thr Trp His Val Cys  Glu Ser Glu 
    2960                 2965                 2970             


Asp Arg  Glu Glu Val Val Val  Cys Glu Leu Cys Glu  Cys Ser Val 
    2975                 2980                 2985             


Val Ser  Phe Asn Gln His Met  Lys Arg Asn His Pro  Gly Cys Gly 
    2990                 2995                 3000             


Arg Ser  Ala Asn Arg Gln Gly  Tyr Arg Ser Asn Gly  Ser Tyr Val 
    3005                 3010                 3015             


Asp Gly  Trp Phe Gly Gly Glu  Cys Gly Ser Gly Asn  Pro Tyr Tyr 
    3020                 3025                 3030             


Leu Leu  Cys Gly Thr Cys Arg  Glu Lys Tyr Leu Ala  Met Lys Thr 
    3035                 3040                 3045             


Lys Ser  Lys Ser Thr Ser Ser  Glu Arg Tyr Lys Gly  Gln Ala Pro 
    3050                 3055                 3060             


Asp Leu  Ile Gly Lys Gln Asp  Ser Val Tyr Glu Glu  Asp Trp Asp 
    3065                 3070                 3075             


Met Leu  Asp Val Asp Glu Asp  Glu Lys Leu Thr Gly  Glu Glu Glu 
    3080                 3085                 3090             


Phe Glu  Leu Leu Ala Gly Pro  Leu Gly Leu Asn Asp  Arg Arg Ile 
    3095                 3100                 3105             


Val Pro  Glu Pro Val Gln Phe  Pro Asp Ser Asp Pro  Leu Gly Ala 
    3110                 3115                 3120             


Ser Val  Ala Met Val Thr Ala  Thr Asn Ser Met Glu  Glu Thr Leu 
    3125                 3130                 3135             


Met Gln  Ile Gly Cys His Gly  Ser Val Glu Lys Ser  Ser Ser Gly 
    3140                 3145                 3150             


Arg Ile  Thr Leu Gly Glu Gln  Ala Ala Ala Leu Ala  Asn Pro His 
    3155                 3160                 3165             


Asp Arg  Val Val Ala Leu Arg  Arg Val Thr Ala Ala  Ala Gln Val 
    3170                 3175                 3180             


Leu Leu  Ala Arg Thr Met Val  Met Arg Ala Leu Ser  Leu Leu Ser 
    3185                 3190                 3195             


Val Ser  Gly Ser Ser Cys Ser  Leu Ala Ala Gly Leu  Glu Ser Leu 
    3200                 3205                 3210             


Gly Leu  Thr Asp Ile Arg Thr  Leu Val Arg Leu Met  Cys Leu Ala 
    3215                 3220                 3225             


Ala Ala  Gly Arg Ala Gly Leu  Ser Thr Ser Pro Ser  Ala Met Ala 
    3230                 3235                 3240             


Ser Thr  Ser Glu Arg Ser Arg  Gly Gly His Ser Lys  Ala Asn Lys 
    3245                 3250                 3255             


Pro Ile  Ser Cys Leu Ala Tyr  Leu Ser Thr Ala Val  Gly Cys Leu 
    3260                 3265                 3270             


Ala Ser  Asn Ala Pro Ser Ala  Ala Lys Leu Leu Val  Gln Leu Cys 
    3275                 3280                 3285             


Thr Gln  Asn Leu Ile Ser Ala  Ala Thr Gly Val Asn  Leu Thr Thr 
    3290                 3295                 3300             


Val Asp  Asp Ser Ile Gln Arg  Lys Phe Leu Pro Ser  Phe Leu Arg 
    3305                 3310                 3315             


Gly Ile  Ala Glu Glu Asn Lys  Leu Val Thr Ser Pro  Asn Phe Val 
    3320                 3325                 3330             


Val Thr  Gln Ala Leu Val Ala  Leu Leu Ala Asp Lys  Gly Ala Lys 
    3335                 3340                 3345             


Leu Arg  Pro Asn Tyr Asp Lys  Ser Glu Val Glu Lys  Lys Gly Pro 
    3350                 3355                 3360             


Leu Glu  Leu Ala Asn Ala Leu  Ala Ala Cys Cys Leu  Ser Ser Arg 
    3365                 3370                 3375             


Leu Ser  Ser Gln His Arg Gln  Trp Ala Ala Gln Gln  Leu Val Arg 
    3380                 3385                 3390             


Thr Leu  Ala Ala His Asp Arg  Asp Asn Gln Thr Thr  Leu Gln Thr 
    3395                 3400                 3405             


Leu Ala  Asp Met Gly Gly Asp  Leu Arg Lys Cys Ser  Phe Ile Lys 
    3410                 3415                 3420             


Leu Glu  Ala His Gln Asn Arg  Val Met Thr Cys Val  Trp Cys Asn 
    3425                 3430                 3435             


Lys Lys  Gly Leu Leu Ala Thr  Ser Gly Asn Asp Gly  Thr Ile Arg 
    3440                 3445                 3450             


Val Trp  Asn Val Thr Lys Lys  Gln Tyr Ser Leu Gln  Gln Thr Cys 
    3455                 3460                 3465             


Val Phe  Asn Arg Leu Glu Gly  Asp Ala Glu Glu Ser  Leu Gly Ser 
    3470                 3475                 3480             


Pro Ser  Asp Pro Ser Phe Ser  Pro Val Ser Trp Ser  Ile Ser Gly 
    3485                 3490                 3495             


Lys Tyr  Leu Ala Gly Ala Leu  Glu Lys Met Val Asn  Ile Trp Gln 
    3500                 3505                 3510             


Val Asn  Gly Gly Lys Gly Leu  Val Asp Ile Gln Pro  His Trp Val 
    3515                 3520                 3525             


Ser Ala  Leu Ala Trp Pro Glu  Glu Gly Pro Ala Thr  Ala Trp Ser 
    3530                 3535                 3540             


Gly Glu  Ser Pro Glu Leu Leu  Leu Val Gly Arg Met  Asp Gly Ser 
    3545                 3550                 3555             


Leu Gly  Leu Ile Glu Val Val  Asp Val Ser Thr Met  His Arg Arg 
    3560                 3565                 3570             


Glu Leu  Glu His Cys Tyr Arg  Lys Asp Val Ser Val  Thr Cys Ile 
    3575                 3580                 3585             


Ala Trp  Phe Ser Glu Asp Arg  Pro Phe Ala Val Gly  Tyr Phe Asp 
    3590                 3595                 3600             


Gly Lys  Leu Leu Leu Gly Thr  Lys Glu Pro Leu Glu  Lys Gly Gly 
    3605                 3610                 3615             


Ile Val  Leu Ile Asp Ala His  Lys Asp Thr Leu Ile  Ser Met Lys 
    3620                 3625                 3630             


Trp Asp  Pro Thr Gly His Ile  Leu Met Thr Cys Ala  Lys Glu Asp 
    3635                 3640                 3645             


Ser Val  Lys Leu Trp Gly Ser  Ile Ser Gly Cys Trp  Cys Cys Leu 
    3650                 3655                 3660             


His Ser  Leu Cys His Pro Ser  Ile Val Asn Gly Ile  Ala Trp Cys 
    3665                 3670                 3675             


Arg Leu  Pro Gly Lys Gly Ser  Lys Leu Gln Leu Leu  Met Ala Thr 
    3680                 3685                 3690             


Gly Cys  Gln Ser Gly Leu Val  Cys Val Trp Arg Ile  Pro Gln Asp 
    3695                 3700                 3705             


Thr Thr  Gln Thr Asn Val Thr  Ser Ala Glu Gly Trp  Trp Glu Gln 
    3710                 3715                 3720             


Glu Ser  Asn Cys Gln Asp Gly  Tyr Arg Lys Ser Ser  Gly Ala Lys 
    3725                 3730                 3735             


Cys Val  Tyr Gln Leu Arg Gly  His Ile Thr Pro Val  Arg Thr Val 
    3740                 3745                 3750             


Ala Phe  Ser Ser Asp Gly Leu  Ala Leu Val Ser Gly  Gly Leu Gly 
    3755                 3760                 3765             


Gly Leu  Met Asn Ile Trp Ser  Leu Arg Asp Gly Ser  Val Leu Gln 
    3770                 3775                 3780             


Thr Val  Val Ile Gly Ser Gly  Ala Ile Gln Thr Thr  Val Trp Ile 
    3785                 3790                 3795             


Pro Glu  Val Gly Val Ala Ala  Cys Ser Asn Arg Ser  Lys Asp Val 
    3800                 3805                 3810             


Leu Val  Val Asn Cys Thr Ala  Glu Trp Ala Ala Ala  Asn His Val 
    3815                 3820                 3825             


Leu Ala  Thr Cys Arg Thr Ala  Leu Lys Gln Gln Gly  Val Leu Gly 
    3830                 3835                 3840             


Leu Asn  Met Ala Pro Cys Met  Arg Ala Phe Leu Glu  Arg Leu Pro 
    3845                 3850                 3855             


Met Met  Leu Gln Glu Gln Tyr  Ala Tyr Glu Lys Pro  His Val Val 
    3860                 3865                 3870             


Cys Gly  Asp Gln Leu Val His  Ser Pro Tyr Met Gln  Cys Leu Ala 
    3875                 3880                 3885             


Ser Leu  Ala Val Gly Leu His  Leu Asp Gln Leu Leu  Cys Asn Pro 
    3890                 3895                 3900             


Pro Val  Pro Pro His His Gln  Asn Cys Leu Pro Asp  Pro Ala Ser 
    3905                 3910                 3915             


Trp Asn  Pro Asn Glu Trp Ala  Trp Leu Glu Cys Phe  Ser Thr Thr 
    3920                 3925                 3930             


Ile Lys  Ala Ala Glu Ala Leu  Thr Asn Gly Ala Gln  Phe Pro Glu 
    3935                 3940                 3945             


Ser Phe  Thr Val Pro Asp Leu  Glu Pro Val Pro Glu  Asp Glu Leu 
    3950                 3955                 3960             


Val Phe  Leu Met Asp Asn Ser  Lys Trp Ile Asn Gly  Met Asp Glu 
    3965                 3970                 3975             


Gln Ile  Met Ser Trp Ala Thr  Ser Arg Pro Glu Asp  Trp His Leu 
    3980                 3985                 3990             


Gly Gly  Lys Cys Asp Val Tyr  Leu Trp Gly Ala Gly  Arg His Gly 
    3995                 4000                 4005             


Gln Leu  Ala Glu Ala Gly Arg  Asn Val Met Val Pro  Ala Ala Ala 
    4010                 4015                 4020             


Pro Ser  Phe Ser Gln Ala Gln  Gln Val Ile Cys Gly  Gln Asn Cys 
    4025                 4030                 4035             


Thr Phe  Val Ile Gln Ala Asn  Gly Thr Val Leu Ala  Cys Gly Glu 
    4040                 4045                 4050             


Gly Ser  Tyr Gly Arg Leu Gly  Gln Gly Asn Ser Asp  Asp Leu His 
    4055                 4060                 4065             


Val Leu  Thr Val Ile Ser Ala  Leu Gln Gly Phe Val  Val Thr Gln 
    4070                 4075                 4080             


Leu Val  Thr Ser Cys Gly Ser  Asp Gly His Ser Met  Ala Leu Thr 
    4085                 4090                 4095             


Glu Ser  Gly Glu Val Phe Ser  Trp Gly Asp Gly Asp  Tyr Gly Lys 
    4100                 4105                 4110             


Leu Gly  His Gly Asn Ser Asp  Arg Gln Arg Arg Pro  Arg Gln Ile 
    4115                 4120                 4125             


Glu Ala  Leu Gln Gly Glu Glu  Val Val Gln Met Ser  Cys Gly Phe 
    4130                 4135                 4140             


Lys His  Ser Ala Val Val Thr  Ser Asp Gly Lys Leu  Phe Thr Phe 
    4145                 4150                 4155             


Gly Asn  Gly Asp Tyr Gly Arg  Leu Gly Leu Gly Asn  Thr Ser Asn 
    4160                 4165                 4170             


Lys Lys  Leu Pro Glu Arg Val  Thr Ala Leu Glu Gly  Tyr Gln Ile 
    4175                 4180                 4185             


Gly Gln  Val Ala Cys Gly Leu  Asn His Thr Leu Ala  Val Ser Ala 
    4190                 4195                 4200             


Asp Gly  Ser Met Val Trp Ala  Phe Gly Asp Gly Asp  Tyr Gly Lys 
    4205                 4210                 4215             


Leu Gly  Leu Gly Asn Ser Thr  Ala Lys Ser Ser Pro  Gln Lys Ile 
    4220                 4225                 4230             


Asp Val  Leu Cys Gly Ile Gly  Ile Lys Lys Val Ala  Cys Gly Thr 
    4235                 4240                 4245             


Gln Phe  Ser Val Ala Leu Thr  Lys Asp Gly His Val  Tyr Thr Phe 
    4250                 4255                 4260             


Gly Gln  Asp Arg Leu Ile Gly  Leu Pro Glu Gly Arg  Ala Arg Asn 
    4265                 4270                 4275             


His Asn  Arg Pro Gln Gln Ile  Pro Val Leu Ala Gly  Val Ile Ile 
    4280                 4285                 4290             


Glu Asp  Val Ala Val Gly Ala  Glu His Thr Leu Ala  Leu Ala Ser 
    4295                 4300                 4305             


Asn Gly  Asp Val Tyr Ala Trp  Gly Ser Asn Ser Glu  Gly Gln Leu 
    4310                 4315                 4320             


Gly Leu  Gly His Thr Asn His  Val Arg Glu Pro Thr  Leu Val Thr 
    4325                 4330                 4335             


Gly Leu  Gln Gly Lys Asn Val  Arg Gln Ile Ser Ala  Gly Arg Cys 
    4340                 4345                 4350             


His Ser  Ala Ala Trp Thr Ala  Pro Pro Val Pro Pro  Arg Ala Pro 
    4355                 4360                 4365             


Gly Val  Ser Val Pro Leu Gln  Leu Gly Leu Pro Asp  Thr Val Pro 
    4370                 4375                 4380             


Pro Gln  Tyr Gly Ala Leu Arg  Glu Val Ser Ile His  Thr Val Arg 
    4385                 4390                 4395             


Ala Arg  Leu Arg Leu Leu Tyr  His Phe Ser Asp Leu  Met Tyr Ser 
    4400                 4405                 4410             


Ser Trp  Arg Leu Leu Asn Leu  Ser Pro Asn Asn Gln  Asn Ser Thr 
    4415                 4420                 4425             


Ser His  Tyr Asn Ala Gly Thr  Trp Gly Ile Val Gln  Gly Gln Leu 
    4430                 4435                 4440             


Arg Pro  Leu Leu Ala Pro Arg  Val Tyr Thr Leu Pro  Met Val Arg 
    4445                 4450                 4455             


Ser Ile  Gly Lys Thr Met Val  Gln Gly Lys Asn Tyr  Gly Pro Gln 
    4460                 4465                 4470             


Ile Thr  Val Lys Arg Ile Ser  Thr Arg Gly Arg Lys  Cys Lys Pro 
    4475                 4480                 4485             


Ile Phe  Val Gln Ile Ala Arg  Gln Val Val Lys Leu  Asn Ala Ser 
    4490                 4495                 4500             


Asp Leu  Arg Leu Pro Ser Arg  Ala Trp Lys Val Lys  Leu Val Gly 
    4505                 4510                 4515             


Glu Gly  Ala Asp Asp Ala Gly  Gly Val Phe Asp Asp  Thr Ile Thr 
    4520                 4525                 4530             


Glu Met  Cys Gln Glu Leu Glu  Thr Gly Ile Val Asp  Leu Leu Ile 
    4535                 4540                 4545             


Pro Ser  Pro Asn Ala Thr Ala  Glu Val Gly Tyr Asn  Arg Asp Arg 
    4550                 4555                 4560             


Phe Leu  Phe Asn Pro Ser Ala  Cys Leu Asp Glu His  Leu Met Gln 
    4565                 4570                 4575             


Phe Lys  Phe Leu Gly Ile Leu  Met Gly Val Ala Ile  Arg Thr Lys 
    4580                 4585                 4590             


Lys Pro  Leu Asp Leu His Leu  Ala Pro Leu Val Trp  Lys Gln Leu 
    4595                 4600                 4605             


Cys Cys  Val Pro Leu Thr Leu  Glu Asp Leu Glu Glu  Val Asp Leu 
    4610                 4615                 4620             


Leu Tyr  Val Gln Thr Leu Asn  Ser Ile Leu His Ile  Glu Asp Ser 
    4625                 4630                 4635             


Gly Ile  Thr Glu Glu Ser Phe  His Glu Met Ile Pro  Leu Asp Ser 
    4640                 4645                 4650             


Phe Val  Gly Gln Ser Ala Asp  Gly Lys Met Val Pro  Ile Ile Pro 
    4655                 4660                 4665             


Gly Gly  Asn Ser Ile Pro Leu  Thr Phe Ser Asn Arg  Lys Glu Tyr 
    4670                 4675                 4680             


Val Glu  Arg Ala Ile Glu Tyr  Arg Leu His Glu Met  Asp Arg Gln 
    4685                 4690                 4695             


Val Ala  Ala Val Arg Glu Gly  Met Ser Trp Ile Val  Pro Val Pro 
    4700                 4705                 4710             


Leu Leu  Ser Leu Leu Thr Ala  Lys Gln Leu Glu Gln  Met Val Cys 
    4715                 4720                 4725             


Gly Met  Pro Glu Ile Ser Val  Glu Val Leu Lys Lys  Val Val Arg 
    4730                 4735                 4740             


Tyr Arg  Glu Val Asp Glu Gln  His Gln Leu Val Gln  Trp Phe Trp 
    4745                 4750                 4755             


His Thr  Leu Glu Glu Phe Ser  Asn Glu Glu Arg Val  Leu Phe Met 
    4760                 4765                 4770             


Arg Phe  Val Ser Gly Arg Ser  Arg Leu Pro Ala Asn  Thr Ala Asp 
    4775                 4780                 4785             


Ile Ser  Gln Arg Phe Gln Ile  Met Lys Val Asp Arg  Pro Tyr Asp 
    4790                 4795                 4800             


Ser Leu  Pro Thr Ser Gln Thr  Cys Phe Phe Gln Leu  Arg Leu Pro 
    4805                 4810                 4815             


Pro Tyr  Ser Ser Gln Leu Val  Met Ala Glu Arg Leu  Arg Tyr Ala 
    4820                 4825                 4830             


Ile Asn  Asn Cys Arg Ser Ile  Asp Met Asp Asn Tyr  Met Leu Ser 
    4835                 4840                 4845             


Arg Asn  Val Asp Asn Ala Glu  Gly Ser Asp Thr Asp  Tyr 
    4850                 4855                 4860     


<210> 7882
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 7882
Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu Thr His Arg Ser Asn Val 
            100                 105                 110         


Ser Leu Leu Glu Pro Tyr Gln Lys Cys Gly Leu Lys Arg Lys Ser Glu 
        115                 120                 125             


Glu Val Asp Ser Asn Gly Ser Val Gln Ile Ile Glu Glu His Pro Pro 
    130                 135                 140                 


Leu Met Leu Gln Asn Arg Thr Val Val Gly Ala Ala Ala Thr Thr Thr 
145                 150                 155                 160 


Thr Val Thr Thr Lys Ser Ser Ser Ser Ser Gly Glu Gly Asp Tyr Gln 
                165                 170                 175     


Leu Val Gln His Glu Ile Leu Cys Ser Met Thr Asn Ser Tyr Glu Val 
            180                 185                 190         


Leu Glu Phe Leu Gly Arg Gly Thr Phe Gly Gln Val Ala Lys Cys Trp 
        195                 200                 205             


Lys Arg Ser Thr Lys Glu Ile Val Ala Ile Lys Ile Leu Lys Asn His 
    210                 215                 220                 


Pro Ser Tyr Ala Arg Gln Gly Gln Ile Glu Val Ser Ile Leu Ser Arg 
225                 230                 235                 240 


Leu Ser Ser Glu Asn Ala Asp Glu Tyr Asn Phe Val Arg Ser Tyr Glu 
                245                 250                 255     


Cys Phe Gln His Lys Asn His Thr Cys Leu Val Phe Glu Met Leu Glu 
            260                 265                 270         


Gln Asn Leu Tyr Asp Phe Leu Lys Gln Asn Lys Phe Ser Pro Leu Pro 
        275                 280                 285             


Leu Lys Tyr Ile Arg Pro Ile Leu Gln Gln Val Ala Thr Ala Leu Met 
    290                 295                 300                 


Lys Leu Lys Ser Leu Gly Leu Ile His Ala Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Met Leu Val Asp Pro Val Arg Gln Pro Tyr Arg Val Lys Val Ile 
                325                 330                 335     


Asp Phe Gly Ser Ala Ser His Val Ser Lys Ala Val Cys Ser Thr Tyr 
            340                 345                 350         


Leu Gln Ser Arg Tyr Tyr Arg Ala Pro Glu Ile Ile Leu Gly Leu Pro 
        355                 360                 365             


Phe Cys Glu Ala Ile Asp Met Trp Ser Leu Gly Cys Val Ile Ala Glu 
    370                 375                 380                 


Leu Phe Leu Gly Trp Pro Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gln 
385                 390                 395                 400 


Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu Pro Ala Glu Tyr Leu Leu 
                405                 410                 415     


Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe Asn Arg Asp Pro Asn Leu 
            420                 425                 430         


Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro Glu Glu His Glu Leu Glu 
        435                 440                 445             


Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys Tyr Ile Phe Asn Cys Leu 
    450                 455                 460                 


Asp Asp Met Ala Gln Val Asn Met Ser Thr Asp Leu Glu Gly Thr Asp 
465                 470                 475                 480 


Met Leu Ala Glu Lys Ala Asp Arg Arg Glu Tyr Ile Asp Leu Leu Lys 
                485                 490                 495     


Lys Met Leu Thr Ile Asp Ala Asp Lys Arg Ile Thr Pro Leu Lys Thr 
            500                 505                 510         


Leu Asn His Gln Phe Val Thr Met Thr His Leu Leu Asp Phe Pro His 
        515                 520                 525             


Ser Asn His Val Lys Ser Cys Phe Gln Asn Met Glu Ile Cys Lys Arg 
    530                 535                 540                 


Arg Val His Met Tyr Asp Thr Val Ser Gln Ile Lys Ser Pro Phe Thr 
545                 550                 555                 560 


Thr His Val Ala Pro Asn Thr Ser Thr Asn Leu Thr Met Ser Phe Ser 
                565                 570                 575     


Asn Gln Leu Asn Thr Val His Asn Gln Ala Ser Val Leu Ala Ser Ser 
            580                 585                 590         


Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu Ala Asn Ser Asp Val Ser 
        595                 600                 605             


Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro Ser Ser Ala Ala Pro Val 
    610                 615                 620                 


Pro Gly Val Ala Gln Gln Gly Val Ser Leu Gln Pro Gly Thr Thr Gln 
625                 630                 635                 640 


Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln Thr Phe Ile Val Cys Pro 
                645                 650                 655     


Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr Thr Lys His Ser Gly Phe 
            660                 665                 670         


Pro Val Arg Met Asp Asn Ala Val Pro Ile Val Pro Gln Ala Pro Ala 
        675                 680                 685             


Ala Gln Pro Leu Gln Ile Gln Ser Gly Val Leu Thr Gln Gly Ser Cys 
    690                 695                 700                 


Thr Pro Leu Met Val Ala Thr Leu His Pro Gln Val Ala Thr Ile Thr 
705                 710                 715                 720 


Pro Gln Tyr Ala Val Pro Phe Thr Leu Ser Cys Ala Ala Gly Arg Pro 
                725                 730                 735     


Ala Leu Val Glu Gln Thr Ala Ala Val Leu Gln Ala Trp Pro Gly Gly 
            740                 745                 750         


Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp Gln Gln Leu Pro Gly Val 
        755                 760                 765             


Ala Leu His Asn Ser Val Gln Pro Thr Ala Met Ile Pro Glu Ala Met 
    770                 775                 780                 


Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg Asn Ala His Ser His Gly 
785                 790                 795                 800 


Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro Ser Leu Leu Thr Asn His 
                805                 810                 815     


Val Thr Leu Ala Thr Ala Gln Pro Leu Asn Val Gly Val Ala His Val 
            820                 825                 830         


Val Arg Gln Gln Gln Ser Ser Ser Leu Pro Ser Lys Lys Asn Lys Gln 
        835                 840                 845             


Ser Ala Pro Val Ser Ser Lys Ser Ser Leu Asp Val Leu Pro Ser Gln 
    850                 855                 860                 


Val Tyr Ser Leu Val Gly Ser Ser Pro Leu Arg Thr Thr Ser Ser Tyr 
865                 870                 875                 880 


Asn Ser Leu Val Pro Val Gln Asp Gln His Gln Pro Ile Ile Ile Pro 
                885                 890                 895     


Asp Thr Pro Ser Pro Pro Val Ser Val Ile Thr Ile Arg Ser Asp Thr 
            900                 905                 910         


Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro Ser Ser Ser Gly Leu Lys 
        915                 920                 925             


Pro Arg Ser Asn Val Ile Ser Tyr Val Thr Val Asn Asp Ser Pro Asp 
    930                 935                 940                 


Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser Thr Asp Thr Leu Ser Ala 
945                 950                 955                 960 


Leu Arg Gly Asn Ser Gly Ser Val Leu Glu Gly Pro Gly Arg Val Val 
                965                 970                 975     


Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile Val Pro Pro Leu Lys Thr 
            980                 985                 990         


Gln Leu Gly Asp Cys Thr Val Ala  Thr Gln Ala Ser Gly  Leu Leu Ser 
        995                 1000                 1005             


Asn Lys  Thr Lys Pro Val Ala  Ser Val Ser Gly Gln  Ser Ser Gly 
    1010                 1015                 1020             


Cys Cys  Ile Thr Pro Thr Gly  Tyr Arg Ala Gln Arg  Gly Gly Thr 
    1025                 1030                 1035             


Ser Ala  Ala Gln Pro Leu Asn  Leu Ser Gln Asn Gln  Gln Ser Ser 
    1040                 1045                 1050             


Ala Ala  Pro Thr Ser Gln Glu  Arg Ser Ser Asn Pro  Ala Pro Arg 
    1055                 1060                 1065             


Arg Gln  Gln Ala Phe Val Ala  Pro Leu Ser Gln Ala  Pro Tyr Thr 
    1070                 1075                 1080             


Phe Gln  His Gly Ser Pro Leu  His Ser Thr Gly His  Pro His Leu 
    1085                 1090                 1095             


Ala Pro  Ala Pro Ala His Leu  Pro Ser Gln Ala His  Leu Tyr Thr 
    1100                 1105                 1110             


Tyr Ala  Ala Pro Thr Ser Ala  Ala Ala Leu Gly Ser  Thr Ser Ser 
    1115                 1120                 1125             


Ile Ala  His Leu Phe Ser Pro  Gln Gly Ser Ser Arg  His Ala Ala 
    1130                 1135                 1140             


Ala Tyr  Thr Thr His Pro Ser  Thr Leu Val His Gln  Val Pro Val 
    1145                 1150                 1155             


Ser Val  Gly Pro Ser Leu Leu  Thr Ser Ala Ser Val  Ala Pro Ala 
    1160                 1165                 1170             


Gln Tyr  Gln His Gln Phe Ala  Thr Gln Ser Tyr Ile  Gly Ser Ser 
    1175                 1180                 1185             


Arg Gly  Ser Thr Ile Tyr Thr  Gly Tyr Pro Leu Ser  Pro Thr Lys 
    1190                 1195                 1200             


Ile Ser  Gln Tyr Ser Tyr Leu  
    1205                 1210 


<210> 7883
<211> 192
<212> PRT
<213> Homo sapiens

<400> 7883
Met Gly Lys Gly Cys Lys Val Val Val Cys Gly Leu Leu Ser Val Gly 
1               5                   10                  15      


Lys Thr Ala Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Thr Ile Gly 
            20                  25                  30          


Met Glu Asp Cys Glu Thr Met Glu Asp Val Tyr Met Ala Ser Val Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Lys Glu Gln Leu His Leu Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Gln Glu Gly Val Glu Leu Pro Lys His Tyr Phe Ser Phe Ala Asp 
65                  70                  75                  80  


Gly Phe Val Leu Val Tyr Ser Val Asn Asn Leu Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Phe Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Ala Ile Val Val Leu Gly Asn Lys Ile Asp Leu Ser Glu Gln Arg 
        115                 120                 125             


Gln Val Asp Ala Glu Val Ala Gln Gln Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Arg Leu Trp Glu Val Thr Val Thr Asp Arg Lys Thr Leu Ile Glu Pro 
145                 150                 155                 160 


Phe Thr Leu Leu Ala Ser Lys Leu Ser Gln Pro Gln Ser Lys Ser Ser 
                165                 170                 175     


Phe Pro Leu Pro Gly Arg Lys Asn Lys Gly Asn Ser Asn Ser Glu Asn 
            180                 185                 190         


<210> 7884
<211> 600
<212> PRT
<213> Homo sapiens

<400> 7884
Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser Val 
        115                 120                 125             


Tyr Leu Ser Tyr Glu Lys Arg Ala Glu Thr Leu Ala Val Glu Ile Lys 
    130                 135                 140                 


Glu Leu Gln Gly Gln Leu Ala Asp Tyr Asn Met Leu Val Asp Lys Leu 
145                 150                 155                 160 


Asn Thr Asn Thr Glu Met Glu Glu Val Met Asn Asp Tyr Asn Met Leu 
                165                 170                 175     


Lys Ala Gln Asn Asp Arg Glu Thr Gln Ser Leu Asp Val Ile Phe Thr 
            180                 185                 190         


Glu Arg Gln Ala Lys Glu Lys Gln Ile Arg Ser Val Glu Glu Glu Ile 
        195                 200                 205             


Glu Gln Glu Lys Gln Ala Thr Asp Asp Ile Ile Lys Asn Met Ser Phe 
    210                 215                 220                 


Glu Asn Gln Val Lys Tyr Leu Glu Met Lys Thr Thr Asn Glu Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Asp Thr Leu Gln Gln Gln Leu Asp Ser Gln Asn Met 
                245                 250                 255     


Lys Lys Glu Ser Leu Glu Ala Glu Ile Ala His Ser Gln Val Lys Gln 
            260                 265                 270         


Glu Ala Val Leu Leu His Glu Lys Leu Tyr Glu Leu Glu Ser His Arg 
        275                 280                 285             


Asp Gln Met Ile Ala Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala 
305                 310                 315                 320 


Ser Met Glu Arg Gln Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe 
                325                 330                 335     


Ile Glu Glu Ile Arg Gln Leu Asp Met Asp Leu Glu Glu His Gln Gly 
            340                 345                 350         


Glu Met Asn Gln Lys Tyr Lys Glu Leu Lys Lys Arg Glu Glu His Met 
        355                 360                 365             


Asp Thr Phe Ile Glu Thr Phe Glu Glu Thr Lys Asn Gln Glu Leu Lys 
    370                 375                 380                 


Arg Lys Ala Gln Ile Glu Ala Asn Ile Val Ala Leu Leu Glu His Cys 
385                 390                 395                 400 


Ser Arg Asn Ile Asn Arg Ile Glu Gln Ile Ser Ser Ile Thr Asn Gln 
                405                 410                 415     


Glu Leu Lys Met Met Gln Asp Asp Leu Asn Phe Lys Ser Thr Glu Val 
            420                 425                 430         


Gln Lys Ser Gln Ser Thr Ala Gln Asn Leu Thr Ser Asp Ile Gln Arg 
        435                 440                 445             


Leu Gln Leu Asp Leu Gln Lys Met Glu Leu Leu Glu Ser Lys Met Thr 
    450                 455                 460                 


Glu Glu Gln His Ser Leu Lys Ser Lys Ile Lys Gln Met Thr Thr Asp 
465                 470                 475                 480 


Leu Glu Ile Tyr Asn Asp Leu Pro Ala Leu Lys Ser Ser Gly Glu Glu 
                485                 490                 495     


Lys Ile Lys Lys Leu His Gln Glu Arg Met Ile Leu Ser Thr His Arg 
            500                 505                 510         


Asn Ala Phe Lys Lys Ile Met Glu Lys Gln Asn Ile Glu Tyr Glu Ala 
        515                 520                 525             


Leu Lys Thr Gln Leu Gln Glu Asn Glu Thr His Ser Gln Leu Thr Asn 
    530                 535                 540                 


Leu Glu Arg Lys Trp Gln His Leu Glu Gln Asn Asn Phe Ala Met Lys 
545                 550                 555                 560 


Glu Phe Ile Ala Thr Lys Ser Gln Glu Ser Asp Tyr Gln Pro Ile Lys 
                565                 570                 575     


Lys Asn Val Thr Lys Gln Ile Ala Glu Tyr Asn Lys Thr Ile Val Asp 
            580                 585                 590         


Ala Leu His Ser Thr Ser Gly Asn 
        595                 600 


<210> 7885
<211> 398
<212> PRT
<213> Homo sapiens

<400> 7885
Met Leu Arg Arg Lys Pro Ser Asn Ala Ser Glu Lys Glu Phe Asn Leu 
1               5                   10                  15      


Asp Asp Asn Ile Pro Glu Asp Asp Ser Gly Val Pro Thr Pro Glu Asp 
            20                  25                  30          


Ala Gly Lys Ser Gly Lys Lys Leu Gly Lys Lys Trp Arg Ala Val Ile 
        35                  40                  45              


Ser Arg Thr Met Asn Arg Lys Met Gly Lys Met Met Val Lys Ala Leu 
    50                  55                  60                  


Ser Glu Glu Met Ala Asp Thr Leu Glu Glu Gly Ser Ala Ser Pro Thr 
65                  70                  75                  80  


Ser Pro Asp Tyr Ser Leu Asp Ser Pro Gly Pro Glu Lys Met Ala Leu 
                85                  90                  95      


Ala Phe Ser Glu Gln Glu Glu His Glu Leu Pro Val Leu Ser Arg Gln 
            100                 105                 110         


Ala Ser Thr Gly Ser Glu Leu Cys Ser Pro Ser Pro Gly Ser Gly Ser 
        115                 120                 125             


Phe Gly Glu Glu Pro Pro Ala Pro Gln Tyr Thr Gly Pro Phe Cys Gly 
    130                 135                 140                 


Arg Ala Arg Val His Thr Asp Phe Thr Pro Ser Pro Tyr Asp His Asp 
145                 150                 155                 160 


Ser Leu Lys Leu Gln Val Arg Ser Ala Ser Gly Leu Leu Trp Ser Leu 
                165                 170                 175     


Ala Gly Cys Ala Gln Lys Gly Ser Trp Thr Glu Pro Gly Tyr Asp Ser 
            180                 185                 190         


Val Ser Gly Gly Gln Gly Pro Pro Tyr Pro Leu Ser Leu Ala Pro Phe 
        195                 200                 205             


Ser Ser Pro Leu Pro Gln Gln Lys Gly Asp Val Ile Gln Ile Ile Glu 
    210                 215                 220                 


Lys Pro Pro Val Gly Thr Trp Leu Gly Leu Leu Asn Gly Lys Val Gly 
225                 230                 235                 240 


Ser Phe Lys Phe Ile Tyr Val Asp Val Leu Pro Glu Glu Ala Val Gly 
                245                 250                 255     


His Ala Arg Pro Ser Arg Arg Gln Ser Lys Gly Lys Arg Pro Lys Pro 
            260                 265                 270         


Lys Thr Leu His Glu Leu Leu Glu Arg Ile Gly Leu Glu Glu His Thr 
        275                 280                 285             


Ser Thr Leu Leu Leu Asn Gly Tyr Gln Thr Leu Glu Asp Phe Lys Glu 
    290                 295                 300                 


Leu Arg Glu Thr His Leu Asn Glu Leu Asn Ile Met Asp Pro Gln His 
305                 310                 315                 320 


Arg Ala Lys Leu Leu Thr Ala Ala Glu Leu Leu Leu Asp Tyr Asp Thr 
                325                 330                 335     


Gly Ser Glu Glu Ala Glu Glu Gly Ala Glu Ser Ser Gln Glu Pro Val 
            340                 345                 350         


Ala His Thr Val Ser Glu Pro Lys Val Asp Ile Pro Arg Asp Ser Gly 
        355                 360                 365             


Cys Phe Glu Gly Ser Glu Ser Gly Arg Asp Asp Ala Glu Leu Ala Gly 
    370                 375                 380                 


Thr Glu Glu Gln Leu Gln Gly Leu Ser Leu Ala Gly Ala Pro 
385                 390                 395             


<210> 7886
<211> 333
<212> PRT
<213> Homo sapiens

<400> 7886
Met Gly Thr Arg Lys Lys Val His Ala Phe Val Arg Val Lys Pro Thr 
1               5                   10                  15      


Asp Asp Phe Ala His Glu Met Ile Arg Tyr Gly Asp Asp Lys Arg Ser 
            20                  25                  30          


Ile Asp Ile His Leu Lys Lys Asp Ile Arg Arg Gly Val Val Asn Asn 
        35                  40                  45              


Gln Gln Thr Asp Trp Ser Phe Lys Leu Asp Gly Val Leu His Asp Ala 
    50                  55                  60                  


Ser Gln Asp Leu Val Tyr Glu Thr Val Ala Lys Asp Val Val Ser Gln 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Gly Thr Ile Met Cys Tyr Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Lys Thr Tyr Thr Met Met Gly Ala Thr Glu Asn Tyr Lys His 
            100                 105                 110         


Arg Gly Ile Leu Pro Arg Ala Leu Gln Gln Val Phe Arg Met Ile Glu 
        115                 120                 125             


Glu Arg Pro Thr His Ala Ile Thr Val Arg Val Ser Tyr Leu Glu Ile 
    130                 135                 140                 


Tyr Asn Glu Ser Leu Phe Asp Leu Leu Ser Thr Leu Pro Tyr Val Gly 
145                 150                 155                 160 


Pro Ser Val Thr Pro Met Thr Ile Val Glu Asn Pro Gln Gly Val Phe 
                165                 170                 175     


Ile Lys Gly Leu Ser Val His Leu Thr Ser Gln Glu Glu Asp Ala Phe 
            180                 185                 190         


Ser Leu Leu Phe Glu Gly Glu Thr Asn Arg Ile Ile Ala Ser His Thr 
        195                 200                 205             


Met Asn Lys Asn Ser Ser Arg Ser His Cys Ile Phe Thr Ile Tyr Leu 
    210                 215                 220                 


Glu Ala His Ser Arg Thr Leu Ser Glu Glu Lys Tyr Ile Thr Ser Lys 
225                 230                 235                 240 


Ile Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Gly Lys Ser Gly 
                245                 250                 255     


Ser Glu Gly Gln Val Leu Lys Glu Ala Thr Tyr Ile Asn Lys Ser Leu 
            260                 265                 270         


Ser Phe Leu Glu Gln Ala Ile Ile Ala Leu Gly Asp Gln Lys Arg Asp 
        275                 280                 285             


His Ile Pro Phe Arg Gln Cys Lys Leu Thr His Ala Leu Lys Asp Ser 
    290                 295                 300                 


Leu Gly Gly Asn Cys Asn Met Val Leu Val Thr Asn Ile Tyr Gly Glu 
305                 310                 315                 320 


Ala Ala Gln Leu Glu Glu Thr Gly Ser Arg Leu Trp Leu 
                325                 330             


<210> 7887
<211> 415
<212> PRT
<213> Homo sapiens

<400> 7887
Met Met Leu Gly Pro Glu Gly Gly Glu Gly Phe Val Val Lys Leu Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Val Glu Asp Val Gln Asn Phe Leu Ser 
            20                  25                  30          


Asp Cys Thr Ile His Asp Gly Ala Ala Gly Val His Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Gln Ser Gly Glu Ala Phe Val Glu Leu Gly Ser Glu 
    50                  55                  60                  


Asp Asp Val Lys Met Ala Leu Lys Lys Asp Arg Glu Ser Met Gly His 
65                  70                  75                  80  


Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu Glu Val Arg 
            180                 185                 190         


Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly Ile Val Lys 
    210                 215                 220                 


Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser Thr Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr Gly Phe Thr 
                245                 250                 255     


Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser Gly Met Tyr 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr Gly Ala Ser 
        355                 360                 365             


Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly Val Ser Ala 
    370                 375                 380                 


Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val Ser Gly Cys 
385                 390                 395                 400 


Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly Tyr Asp 
                405                 410                 415 


<210> 7888
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 7888
Met Ser Glu Gln Glu Arg Ile Gln Glu Cys Leu Arg Lys Glu Ile Arg 
1               5                   10                  15      


Ser Leu Leu Ile Ser Thr Lys Asp Gly Leu Ser Pro Gln Glu Leu Glu 
            20                  25                  30          


Lys Glu Tyr Leu Leu Met Val Gly Asn His Leu Pro Leu Arg Ile Leu 
        35                  40                  45              


Gly Tyr Arg Ser Thr Met Glu Leu Val Leu Asp Met Pro Asp Val Val 
    50                  55                  60                  


Arg Val Cys Pro Gly Ala Gly Gly Thr Val Ile Leu Lys Ala Ile Pro 
65                  70                  75                  80  


Asp Glu Ser Thr Lys Gly Ile Ala Ser Leu Val Ala Lys Gln Arg Ser 
                85                  90                  95      


Ser His Lys Leu Arg Asn Ser Met His Lys Gly Arg Pro Ser Ile Tyr 
            100                 105                 110         


Ser Gly Pro Arg Ser His Arg Arg Val Pro Tyr Arg Gly Arg Val Ala 
        115                 120                 125             


Pro Ile Leu Pro Ala Val Val Lys Ser Glu Leu Lys Asp Leu Leu Ala 
    130                 135                 140                 


Leu Ser Pro Val Leu Leu Ser Asp Phe Glu Lys Ala Phe Ala Lys Arg 
145                 150                 155                 160 


Phe Gly Arg Ser Phe Gln Tyr Met Gln Tyr Gly Phe Leu Ser Met Phe 
                165                 170                 175     


Glu Val Leu Asn Ala Ala Ser Asp Val Ile Ser Val Glu Gln Thr Arg 
            180                 185                 190         


Ala Gly Ser Leu Leu Met Leu Lys Lys Ser Val Thr Glu Glu Lys Pro 
        195                 200                 205             


Arg Gly Cys Pro Ala Gly Lys Ile Phe Thr Gln Pro Phe Arg Met Lys 
    210                 215                 220                 


Gln Gly Ser Tyr Ser Thr Gly Phe Pro Val Ala Lys Pro Cys Phe Ser 
225                 230                 235                 240 


Gln Pro Thr Ser Asn Met Glu Pro Pro Lys Gln Ile Met Ser Met Glu 
                245                 250                 255     


Lys Thr Ser Lys Leu Asn Val Val Glu Thr Ser Arg Leu Asn His Thr 
            260                 265                 270         


Glu Lys Leu Asn Gln Leu Glu Asn Thr Phe Lys Ser Val Ile Ala Gln 
        275                 280                 285             


Ile Gly Pro Gly Gly Thr Ile Ser Ser Glu Leu Lys His Lys Ile Lys 
    290                 295                 300                 


Phe Val Val Ser Lys Phe Pro Glu Gly Leu Phe Ile Ser Lys Leu Leu 
305                 310                 315                 320 


Gly Glu Tyr Glu Val Ile Phe Lys Glu Gln Leu Ser Pro Lys Lys Leu 
                325                 330                 335     


Gly Phe Leu Asn Val Thr Glu Leu Val Gly Ala Leu Ser Asp Ile Leu 
            340                 345                 350         


His Val Glu Phe Arg Lys Gly His Gln Asp Leu Leu Val Phe Asp Ala 
        355                 360                 365             


Asp Lys Lys Pro Leu Pro Pro Val Gln Ser Asp Lys Lys Ile Glu Ala 
    370                 375                 380                 


Lys Ala Cys Val Ser Ser Pro Pro Arg Asn Ser Leu Ser Thr Ala Ala 
385                 390                 395                 400 


Val Lys Glu Thr Val Trp Asn Cys Pro Ser Lys Lys Gln Lys Glu Pro 
                405                 410                 415     


Gln Gln Lys Ile Cys Lys Lys Pro Asn Leu Val Val Lys Pro Leu Gln 
            420                 425                 430         


Leu Gln Val Glu Thr Asn Lys Ser Glu Leu Asn Leu Ala Met Ala Asn 
        435                 440                 445             


His Asp Ile Pro Pro Asp Ala Val Pro Asn Lys Lys Leu Cys Arg Leu 
    450                 455                 460                 


Pro Pro Leu Asp Thr Ser Ser Leu Ile Gly Val Phe Val Glu Tyr Ile 
465                 470                 475                 480 


Ile Ser Pro Ser Gln Phe Tyr Ile Arg Ile Tyr Ser Arg Asp Ser Ser 
                485                 490                 495     


Glu Leu Leu Glu Asp Met Met Ile Glu Met Arg Arg Cys Tyr Ser Asn 
            500                 505                 510         


Gln Leu Val Ser Asp Arg Tyr Val Met Pro Glu Cys Phe Ile Gln Pro 
        515                 520                 525             


Gly His Leu Cys Cys Val Arg Ile Ser Glu Asp Lys Trp Trp Tyr Arg 
    530                 535                 540                 


Val Ile Ile His Arg Val Leu Glu Lys Gln Glu Val Glu Val Phe Tyr 
545                 550                 555                 560 


Pro Asp Phe Gly Asn Ile Gly Ile Val Gln Lys Ser Ser Leu Arg Phe 
                565                 570                 575     


Leu Lys Cys Cys Tyr Thr Lys Leu Pro Ala Gln Ala Ile Pro Cys Ser 
            580                 585                 590         


Leu Ala Trp Val Arg Pro Val Glu Glu His Trp Thr Ser Lys Ala Ile 
        595                 600                 605             


Leu Gln Phe Gln Lys Leu Cys Gly Leu Lys Pro Leu Val Gly Val Val 
    610                 615                 620                 


Asp Glu Tyr Val Asp Gly Ile Leu Asn Ile Phe Leu Cys Asp Thr Ser 
625                 630                 635                 640 


Ser Asn Glu Asp Val Tyr Phe His His Val Leu Arg Thr Glu Gly His 
                645                 650                 655     


Ala Ile Val Cys Arg Glu Asn Ile Ser Ser Lys Gly Phe Ser Glu Leu 
            660                 665                 670         


Asn Pro Leu Ala Leu Tyr Thr Thr Ser Ser Gly Gly Pro Glu Asp Ile 
        675                 680                 685             


Val Leu Thr Glu Leu Gly Tyr Pro Ser Gln Gln His Tyr Phe Asn Glu 
    690                 695                 700                 


Asp Arg Lys Ile Ser Pro Gln Ser Lys Glu Ser Glu Leu Arg Ile Leu 
705                 710                 715                 720 


Gln Asp Ile Asn Asp Glu Lys Ser Leu Ser His Leu Lys Ser Glu Ser 
                725                 730                 735     


Lys Glu Pro Leu Lys Asp Ser Glu Phe Glu Ser Leu Lys Thr Cys Asn 
            740                 745                 750         


Lys Ser Phe Glu Glu Asp Pro Lys Trp Ser Asn Pro Glu Pro Asn Asp 
        755                 760                 765             


Leu Lys Glu Glu Asn Glu Asp Glu Ile Pro Thr Gly Met Pro Cys Leu 
    770                 775                 780                 


Glu Ser Val Thr Ile Gly Asp Asp Ile Trp Asp Glu Asn Trp Leu Pro 
785                 790                 795                 800 


Leu Gln Ala Lys Met Gly Lys Gly Gly Asp Ala Ala Ser His Leu Phe 
                805                 810                 815     


Thr Ala Ser Leu Gly Gly Lys Asn Gln Tyr Ser Ser Cys Lys Glu Met 
            820                 825                 830         


Pro Gln Lys Asp Trp Cys Phe Ser Thr Pro Lys Asp Thr Trp Asp Asp 
        835                 840                 845             


Ser Trp Gln Pro Ser Gly Leu Val Asn Gly Thr Lys Val Glu Val His 
    850                 855                 860                 


Lys Pro Glu Val Leu Gly Ala Gln Glu Lys Asn Thr Gly Thr Asn Arg 
865                 870                 875                 880 


Thr Gln Lys Gln Leu Asp Ile Asn Gly Ser Ser Asp Ser Ser Thr Leu 
                885                 890                 895     


Pro Lys Leu Glu Glu Phe Cys Thr Ser Leu Thr Gln Ser Glu Gln Ser 
            900                 905                 910         


Ala Asp Gly Ser Gln Ser Glu Pro Asn Asn Ser Gln Thr Gln Pro Lys 
        915                 920                 925             


Gln Ile Gln Leu Ser Thr Ala Ala Pro Cys Ser Thr Thr Ala Val Asp 
    930                 935                 940                 


Asp Ser Ala Glu Lys Pro Ser Gly Ser Val Glu Ser Ser Pro Glu Ile 
945                 950                 955                 960 


Leu Lys Asn Glu Asp Phe Ser Ser Ser Arg Ala Ile Thr Leu Tyr Lys 
                965                 970                 975     


Asp Lys Arg Gln Glu Ser Val Asp Gln Leu Ser Leu Ile Leu Ser Tyr 
            980                 985                 990         


Glu Cys Gln Ile Ser Gln Lys Leu  Tyr Ile Pro Arg Ser  Thr Ala Thr 
        995                 1000                 1005             


Ala Ala  Leu Gly Ala Ala Ala  Arg Leu Ala Thr Ser  Arg Ser Leu 
    1010                 1015                 1020             


Leu His  Trp Tyr Pro Ser Val  Lys Arg Met Glu Ala  
    1025                 1030                 1035 


<210> 7889
<211> 219
<212> PRT
<213> Homo sapiens

<400> 7889
Met Gly Gly Ala Gln Leu Glu Leu Pro Ser Gly Ala Arg Pro Gly Val 
1               5                   10                  15      


Cys Val Arg Arg Ser Phe Arg Ala His Ala Gly Asp Gln Pro Arg Arg 
            20                  25                  30          


Pro Pro Gly Pro Ile Pro Val Pro Gly Thr Met Lys Gln Glu Ser Ala 
        35                  40                  45              


Ala Pro Asn Thr Pro Pro Thr Ser Gln Ser Pro Thr Pro Ser Ala Gln 
    50                  55                  60                  


Phe Pro Arg Asn Asp Gly Asp Pro Gln Ala Leu Trp Ile Phe Gly Tyr 
65                  70                  75                  80  


Gly Ser Leu Val Trp Arg Pro Asp Phe Ala Tyr Ser Asp Ser Arg Val 
                85                  90                  95      


Gly Phe Val Arg Gly Tyr Ser Arg Arg Phe Trp Gln Gly Asp Thr Phe 
            100                 105                 110         


His Arg Gly Ser Asp Lys Met Pro Gly Arg Val Val Thr Leu Leu Glu 
        115                 120                 125             


Asp His Glu Gly Cys Thr Trp Gly Val Ala Tyr Gln Val Gln Gly Glu 
    130                 135                 140                 


Gln Asn Pro Gly Tyr Leu Gly Pro Ala Pro Glu Glu Ala Ile Ala Thr 
145                 150                 155                 160 


Gln Ile Leu Ala Cys Arg Gly Phe Ser Gly His Asn Leu Glu Tyr Leu 
                165                 170                 175     


Leu Arg Leu Ala Asp Phe Met Gln Leu Cys Gly Pro Gln Ala Gln Asp 
            180                 185                 190         


Glu His Leu Ala Ala Ile Val Asp Ala Val Gly Thr Met Leu Pro Cys 
        195                 200                 205             


Phe Cys Pro Thr Glu Gln Ala Leu Ala Leu Val 
    210                 215                 


<210> 7890
<211> 793
<212> PRT
<213> Homo sapiens

<400> 7890
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Glu Ser Ile His Leu Gln Leu Ser Ser 
                85                  90                  95      


Phe Ser Ser Leu Gln Glu Glu Asp Lys Ser Arg Lys Asp Asp Ser Glu 
            100                 105                 110         


Arg Glu Lys Glu Lys Asp Lys Asn Lys Asp Lys Thr Ser Glu Lys Pro 
        115                 120                 125             


Lys Ile Arg Met Leu Ser Lys Asp Cys Ser Gln Glu Tyr Thr Asp Ser 
    130                 135                 140                 


Thr Gly Ile Asp Leu His Glu Phe Leu Ile Asn Thr Leu Lys Asn Asn 
145                 150                 155                 160 


Ser Arg Asp Arg Met Ile Leu Leu Lys Met Glu Gln Glu Ile Ile Asp 
                165                 170                 175     


Phe Ile Ala Asp Asn Asn Asn His Tyr Lys Lys Phe Pro Gln Met Ser 
            180                 185                 190         


Ser Tyr Gln Arg Met Leu Val His Arg Val Ala Ala Tyr Phe Gly Leu 
        195                 200                 205             


Asp His Asn Val Asp Gln Thr Gly Lys Ser Val Ile Ile Asn Lys Thr 
    210                 215                 220                 


Ser Ser Thr Arg Ile Pro Glu Gln Arg Phe Cys Glu His Leu Lys Asp 
225                 230                 235                 240 


Glu Lys Gly Glu Glu Ser Gln Lys Arg Phe Ile Leu Lys Arg Asp Asn 
                245                 250                 255     


Ser Ser Ile Asp Lys Glu Asp Asn Gln Ser Val Cys Ser Gln Glu Ser 
            260                 265                 270         


Leu Phe Val Glu Asn Arg Gly Asn Arg Asp Gly Ser Gly Arg Thr Ser 
        275                 280                 285             


Gly Ser Arg Gln Ser Ser Ser Glu Asn Glu Leu Lys Trp Ser Asp His 
    290                 295                 300                 


Gln Arg Ala Trp Ser Ser Thr Asp Ser Asp Ser Ser Asn Arg Asn Leu 
305                 310                 315                 320 


Lys Pro Ala Met Thr Lys Thr Ala Ser Phe Gly Gly Ile Thr Val Leu 
                325                 330                 335     


Thr Arg Gly Asp Ser Thr Ser Ser Thr Arg Ser Thr Gly Lys Leu Ser 
            340                 345                 350         


Lys Ala Gly Ser Glu Ser Ser Ser Ser Ala Gly Ser Ser Gly Ser Leu 
        355                 360                 365             


Ser Arg Thr His Pro Pro Leu Gln Ser Thr Pro Leu Val Ser Gly Val 
    370                 375                 380                 


Ala Ala Gly Ser Pro Gly Cys Val Pro Tyr Pro Glu Asn Gly Ile Gly 
385                 390                 395                 400 


Gly Gln Val Ala Pro Ser Ser Thr Ser Tyr Ile Leu Leu Pro Leu Glu 
                405                 410                 415     


Ala Ala Thr Gly Ile Pro Pro Gly Ser Ile Leu Leu Asn Pro His Thr 
            420                 425                 430         


Gly Gln Pro Phe Val Asn Pro Asp Gly Thr Pro Ala Ile Tyr Asn Pro 
        435                 440                 445             


Pro Thr Ser Gln Gln Pro Leu Arg Ser Ala Met Val Gly Gln Ser Gln 
    450                 455                 460                 


Gln Gln Pro Pro Gln Gln Gln Pro Ser Pro Gln Pro Gln Gln Gln Val 
465                 470                 475                 480 


Gln Pro Pro Gln Pro Gln Met Ala Gly Pro Leu Val Thr Gln Ser Val 
                485                 490                 495     


Gln Gly Leu Gln Ala Ser Ser Gln Ser Val Gln Tyr Pro Ala Val Ser 
            500                 505                 510         


Phe Pro Pro Gln His Leu Leu Pro Val Ser Pro Thr Gln His Phe Pro 
        515                 520                 525             


Met Arg Asp Asp Val Ala Thr Gln Phe Gly Gln Met Thr Leu Ser Arg 
    530                 535                 540                 


Gln Ser Ser Gly Glu Thr Pro Glu Pro Pro Ser Gly Pro Val Tyr Pro 
545                 550                 555                 560 


Ser Ser Leu Met Pro Gln Pro Ala Gln Gln Pro Ser Tyr Val Ile Ala 
                565                 570                 575     


Ser Thr Gly Gln Gln Leu Pro Thr Gly Gly Phe Ser Gly Ser Gly Pro 
            580                 585                 590         


Pro Ile Ser Gln Gln Val Leu Gln Pro Pro Pro Ser Pro Gln Gly Phe 
        595                 600                 605             


Val Gln Gln Pro Pro Pro Ala Gln Met Pro Val Tyr Tyr Tyr Pro Ser 
    610                 615                 620                 


Gly Gln Tyr Pro Thr Ser Thr Thr Gln Gln Tyr Arg Pro Met Ala Pro 
625                 630                 635                 640 


Val Gln Tyr Asn Ala Gln Arg Ser Gln Gln Met Pro Gln Ala Ala Gln 
                645                 650                 655     


Gln Ala Gly Tyr Gln Pro Val Leu Ser Gly Gln Gln Gly Phe Gln Gly 
            660                 665                 670         


Leu Ile Gly Val Gln Gln Pro Pro Gln Ser Gln Asn Val Ile Asn Asn 
        675                 680                 685             


Gln Gln Gly Thr Pro Val Gln Ser Val Met Val Ser Tyr Pro Thr Met 
    690                 695                 700                 


Ser Ser Tyr Gln Val Pro Met Thr Gln Gly Ser Gln Gly Leu Pro Gln 
705                 710                 715                 720 


Gln Ser Tyr Gln Gln Pro Ile Met Leu Pro Asn Gln Ala Gly Gln Gly 
                725                 730                 735     


Ser Leu Pro Ala Thr Gly Met Pro Val Tyr Cys Asn Val Thr Pro Pro 
            740                 745                 750         


Thr Pro Gln Asn Asn Leu Arg Leu Ile Gly Pro His Cys Pro Ser Ser 
        755                 760                 765             


Thr Val Pro Val Met Ser Ala Ser Cys Arg Thr Asn Cys Ala Ser Met 
    770                 775                 780                 


Ser Asn Ala Gly Trp Gln Val Lys Phe 
785                 790             


<210> 7891
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7891
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 7892
<211> 193
<212> PRT
<213> Homo sapiens

<400> 7892
Met Ala Arg Ala Gly Pro Arg Leu Val Leu Ser Glu Glu Ala Val Arg 
1               5                   10                  15      


Ala Lys Ser Gly Leu Gly Pro His Arg Asp Leu Ala Glu Leu Gln Ser 
            20                  25                  30          


Leu Ser Ile Pro Gly Thr Tyr Gln Glu Lys Ile Thr His Leu Gly His 
        35                  40                  45              


Ser Leu Met Ser Leu Thr Gly Leu Lys Ser Leu Asp Leu Ser Arg Asn 
    50                  55                  60                  


Ser Leu Val Ser Leu Glu Gly Ile Gln Tyr Leu Thr Ala Leu Glu Ser 
65                  70                  75                  80  


Leu Asn Leu Tyr Tyr Asn Cys Ile Ser Ser Leu Ala Glu Val Phe Arg 
                85                  90                  95      


Leu His Ala Leu Thr Glu Leu Val Asp Val Asp Phe Arg Leu Asn Pro 
            100                 105                 110         


Val Val Lys Val Glu Pro Asp Tyr Arg Leu Phe Val Val His Leu Leu 
        115                 120                 125             


Pro Lys Leu Gln Gln Leu Asp Asp Arg Pro Val Arg Ala Ser Glu Arg 
    130                 135                 140                 


Lys Ala Ser Arg Leu His Phe Ala Ser Glu Asp Ser Leu Asp Ser Lys 
145                 150                 155                 160 


Glu Ser Val Pro Ala Ser Leu Lys Glu Gly Arg Ile Gln Thr Ser Val 
                165                 170                 175     


Glu Pro Ala Val Gly Thr Val Pro Val Trp Gly Leu Trp Glu Ala Gly 
            180                 185                 190         


Pro 
    


<210> 7893
<211> 58
<212> PRT
<213> Homo sapiens

<400> 7893
Met Tyr Phe Asn Tyr Lys Ser Val Cys Gly Ser Cys Gly Phe Gly Ser 
1               5                   10                  15      


Cys Tyr Gly Cys Gly Tyr Gly Cys Ile His Ser Thr His Cys Gly Cys 
            20                  25                  30          


Asn Gly Tyr Tyr Gly Cys Tyr Glu Asn Lys Tyr Ser Val Ile Asp Asp 
        35                  40                  45              


Leu Ile Phe Phe Ala Ser Lys Lys Cys His 
    50                  55              


<210> 7894
<211> 194
<212> PRT
<213> Homo sapiens

<400> 7894
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Val Lys Val Asn Lys Tyr Gly Asp Thr Trp 
            180                 185                 190         


Asp Glu 
        


<210> 7895
<211> 806
<212> PRT
<213> Homo sapiens

<400> 7895
Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15      


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30          


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45              


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60                  


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80  


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95      


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110         


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125             


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140                 


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160 


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175     


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190         


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205             


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220                 


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240 


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255     


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270         


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285             


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300                 


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320 


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335     


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350         


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365             


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380                 


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400 


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415     


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430         


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445             


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460                 


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480 


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495     


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510         


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525             


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540                 


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560 


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575     


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590         


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605             


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620                 


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640 


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655     


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670         


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685             


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Ala 
    690                 695                 700                 


Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met Pro Gln Arg 
705                 710                 715                 720 


Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro Tyr Pro Arg 
                725                 730                 735     


Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg Gly Asn Tyr 
            740                 745                 750         


Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln Asn Phe Arg 
        755                 760                 765             


Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln Gly Tyr Asn 
    770                 775                 780                 


Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp Ser Gln His 
785                 790                 795                 800 


Tyr His Gln Gly Tyr Tyr 
                805     


<210> 7896
<211> 216
<212> PRT
<213> Homo sapiens

<400> 7896
Met Ser Thr Val Asp Leu Ala Arg Val Gly Ala Cys Ile Leu Lys His 
1               5                   10                  15      


Ala Val Thr Gly Glu Ala Val Glu Leu Arg Ser Leu Trp Arg Glu His 
            20                  25                  30          


Ala Cys Val Val Ala Gly Leu Arg Arg Phe Gly Cys Val Val Cys Arg 
        35                  40                  45              


Trp Ile Ala Gln Asp Leu Ser Ser Leu Ala Gly Leu Leu Asp Gln His 
    50                  55                  60                  


Gly Val Arg Leu Val Gly Val Gly Pro Glu Ala Leu Gly Leu Gln Glu 
65                  70                  75                  80  


Phe Leu Asp Gly Asp Tyr Phe Ala Gly Glu Leu Tyr Leu Asp Glu Ser 
                85                  90                  95      


Lys Gln Leu Tyr Lys Glu Leu Gly Phe Lys Arg Leu Trp Thr Gln Ala 
            100                 105                 110         


Ser Pro Glu Phe Gly Gln Ala Thr Trp Cys Leu Arg Arg Tyr Asn Ser 
        115                 120                 125             


Leu Ser Ile Leu Pro Ala Ala Leu Gly Lys Pro Val Arg Asp Val Ala 
    130                 135                 140                 


Ala Lys Ala Lys Ala Val Gly Ile Gln Gly Asn Leu Ser Gly Asp Leu 
145                 150                 155                 160 


Leu Gln Ser Gly Gly Leu Leu Val Val Ser Lys Gly Gly Asp Lys Val 
                165                 170                 175     


Leu Leu His Phe Val Gln Lys Ser Pro Gly Asp Tyr Val Pro Lys Glu 
            180                 185                 190         


His Ile Leu Gln Val Leu Gly Ile Ser Ala Glu Val Cys Ala Ser Asp 
        195                 200                 205             


Pro Pro Gln Cys Asp Arg Glu Val 
    210                 215     


<210> 7897
<211> 396
<212> PRT
<213> Homo sapiens

<400> 7897
Met Phe Trp Lys Phe Asp Leu His Thr Ser Ser His Leu Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Leu Ser Leu Pro Glu Leu Leu Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Val Val Asn Arg Lys Leu Leu Asp Phe Leu 
        35                  40                  45              


Leu Gln Pro Pro His Leu Gln Ala Met Val Ala Trp Val Thr Gln Glu 
    50                  55                  60                  


Pro Pro Asp Ser Gly Glu Glu Arg Leu Arg Tyr Lys Tyr Pro Ser Val 
65                  70                  75                  80  


Ala Cys Glu Ile Leu Thr Ser Asp Val Pro Gln Ile Asn Asp Ala Leu 
                85                  90                  95      


Gly Ala Asp Glu Ser Leu Leu Asn Arg Leu Tyr Gly Phe Leu Gln Ser 
            100                 105                 110         


Thr Gly Ser Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Met 
        115                 120                 125             


Gly Ile Leu Ile Asn Arg Lys Thr Asp Gln Leu Val Ser Phe Leu Arg 
    130                 135                 140                 


Lys Lys Asp Asp Phe Val Asp Leu Leu Leu Gln His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Val Glu Arg Pro 
                165                 170                 175     


Gln Leu Arg Gln Asp Val Val Asn Trp Leu Asn Glu Glu Lys Ile Val 
            180                 185                 190         


Gln Arg Leu Ile Glu Gln Ile His Pro Ser Lys Asp Glu Asn Gln His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Asp Ile Ile Arg Leu Ser Arg Glu 
    210                 215                 220                 


Gln Met Ile Gln Val Gln Asp Ser Pro Val Pro Thr Asp Ala Pro Thr 
225                 230                 235                 240 


Ser Pro Arg Val Ser Gly Glu Glu Glu Leu His Thr Gly Pro Pro Ala 
                245                 250                 255     


Pro Gln Gly Pro Leu Ser Val Pro Gln Gly Leu Pro Thr Gln Ser Leu 
            260                 265                 270         


Ala Ser Pro Pro Ala Arg Asp Ala Leu Gln Leu Arg Ser Gln Asp Pro 
        275                 280                 285             


Thr Pro Pro Ser Ala Pro Gln Glu Ala Thr Glu Gly Ser Lys Val Thr 
    290                 295                 300                 


Glu Pro Ser Ala Pro Cys Gln Ala Leu Val Ser Ile Gly Asp Leu Gln 
305                 310                 315                 320 


Ala Thr Phe His Gly Ile Arg Ser Ala Pro Ser Ser Ser Asp Ser Ala 
                325                 330                 335     


Thr Arg Asp Pro Ser Thr Ser Val Pro Ala Ser Gly Ala His Gln Pro 
            340                 345                 350         


Pro Gln Thr Thr Glu Gly Glu Lys Ser Pro Glu Pro Leu Gly Leu Pro 
        355                 360                 365             


Gln Ser Gln Ser Ala Gln Ala Leu Thr Pro Pro Pro Ile Pro Asn Gly 
    370                 375                 380                 


Ser Ala Pro Glu Gly Pro Ala Ser Pro Gly Ser Gln 
385                 390                 395     


<210> 7898
<211> 725
<212> PRT
<213> Homo sapiens

<400> 7898
Met Gly Thr Arg Lys Lys Val His Ala Phe Val Arg Val Lys Pro Thr 
1               5                   10                  15      


Asp Asp Phe Ala His Glu Met Ile Arg Tyr Gly Asp Asp Lys Arg Ser 
            20                  25                  30          


Ile Asp Ile His Leu Lys Lys Asp Ile Arg Arg Gly Val Val Asn Asn 
        35                  40                  45              


Gln Gln Thr Asp Trp Ser Phe Lys Leu Asp Gly Val Leu His Asp Ala 
    50                  55                  60                  


Ser Gln Asp Leu Val Tyr Glu Thr Val Ala Lys Asp Val Val Ser Gln 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Gly Thr Ile Met Cys Tyr Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Lys Thr Tyr Thr Met Met Gly Ala Thr Glu Asn Tyr Lys His 
            100                 105                 110         


Arg Gly Ile Leu Pro Arg Ala Leu Gln Gln Val Phe Arg Met Ile Glu 
        115                 120                 125             


Glu Arg Pro Thr His Ala Ile Thr Val Arg Val Ser Tyr Leu Glu Ile 
    130                 135                 140                 


Tyr Asn Glu Ser Leu Phe Asp Leu Leu Ser Thr Leu Pro Tyr Val Gly 
145                 150                 155                 160 


Pro Ser Val Thr Pro Met Thr Ile Val Glu Asn Pro Gln Gly Val Phe 
                165                 170                 175     


Ile Lys Gly Leu Ser Val His Leu Thr Ser Gln Glu Glu Asp Ala Phe 
            180                 185                 190         


Ser Leu Leu Phe Glu Gly Glu Thr Asn Arg Ile Ile Ala Ser His Thr 
        195                 200                 205             


Met Asn Lys Asn Ser Ser Arg Ser His Cys Ile Phe Thr Ile Tyr Leu 
    210                 215                 220                 


Glu Ala His Ser Arg Thr Leu Ser Glu Glu Lys Tyr Ile Thr Ser Lys 
225                 230                 235                 240 


Ile Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Gly Lys Ser Gly 
                245                 250                 255     


Ser Glu Gly Gln Val Leu Lys Glu Ala Thr Tyr Ile Asn Lys Ser Leu 
            260                 265                 270         


Ser Phe Leu Glu Gln Ala Ile Ile Ala Leu Gly Asp Gln Lys Arg Asp 
        275                 280                 285             


His Ile Pro Phe Arg Gln Cys Lys Leu Thr His Ala Leu Lys Asp Ser 
    290                 295                 300                 


Leu Gly Gly Asn Cys Asn Met Val Leu Val Thr Asn Ile Tyr Gly Glu 
305                 310                 315                 320 


Ala Ala Gln Leu Glu Glu Thr Leu Ser Ser Leu Arg Phe Ala Ser Arg 
                325                 330                 335     


Met Lys Leu Val Thr Thr Glu Pro Ala Ile Asn Glu Lys Tyr Asp Ala 
            340                 345                 350         


Glu Arg Met Val Lys Asn Leu Glu Lys Glu Leu Ala Leu Leu Lys Gln 
        355                 360                 365             


Glu Leu Ala Ile His Asp Ser Leu Thr Asn Arg Thr Phe Val Thr Tyr 
    370                 375                 380                 


Asp Pro Met Asp Glu Ile Gln Ile Ala Glu Ile Asn Ser Gln Val Arg 
385                 390                 395                 400 


Arg Tyr Leu Glu Gly Thr Leu Asp Glu Ile Asp Ile Ile Ser Leu Arg 
                405                 410                 415     


Gln Ile Lys Glu Val Phe Asn Gln Phe Arg Val Val Leu Ser Gln Gln 
            420                 425                 430         


Glu Gln Glu Val Glu Ser Thr Leu Arg Arg Lys Tyr Thr Leu Ile Asp 
        435                 440                 445             


Arg Asn Asp Phe Ala Ala Ile Ser Ala Ile Gln Lys Ala Gly Leu Val 
    450                 455                 460                 


Asp Val Asp Gly His Leu Val Gly Glu Pro Glu Gly Gln Asn Phe Gly 
465                 470                 475                 480 


Leu Gly Val Ala Pro Phe Ser Thr Lys Pro Gly Lys Lys Ala Lys Ser 
                485                 490                 495     


Lys Lys Thr Phe Lys Glu Pro Leu Arg Pro Asp Thr Pro Pro Ser Lys 
            500                 505                 510         


Pro Val Ala Phe Glu Glu Phe Lys Asn Glu Gln Gly Ser Glu Ile Asn 
        515                 520                 525             


Arg Ile Phe Lys Glu Asn Lys Ser Ile Leu Asn Glu Arg Arg Lys Arg 
    530                 535                 540                 


Ala Ser Glu Thr Thr Gln His Ile Asn Ala Ile Lys Arg Glu Ile Asp 
545                 550                 555                 560 


Val Thr Lys Glu Ala Leu Asn Phe Gln Lys Ser Leu Arg Glu Lys Gln 
                565                 570                 575     


Gly Lys Tyr Glu Asn Lys Gly Leu Met Ile Ile Asp Glu Glu Glu Phe 
            580                 585                 590         


Leu Leu Ile Leu Lys Leu Lys Asp Leu Lys Lys Gln Tyr Arg Ser Glu 
        595                 600                 605             


Tyr Gln Asp Leu Arg Asp Leu Arg Ala Glu Ile Gln Tyr Cys Gln His 
    610                 615                 620                 


Leu Val Asp Gln Cys Arg His Arg Leu Leu Met Glu Phe Asp Ile Trp 
625                 630                 635                 640 


Tyr Asn Glu Ser Phe Val Ile Pro Glu Asp Met Gln Met Ala Leu Lys 
                645                 650                 655     


Pro Gly Gly Ser Ile Arg Pro Gly Met Val Pro Val Asn Arg Ile Val 
            660                 665                 670         


Ser Leu Gly Glu Asp Asp Gln Asp Lys Phe Ser Gln Leu Gln Gln Arg 
        675                 680                 685             


Val Leu Pro Glu Gly Pro Asp Ser Ile Ser Phe Tyr Asn Ala Lys Val 
    690                 695                 700                 


Lys Ile Glu Gln Lys His Asn Tyr Leu Lys Thr Met Met Gly Leu Gln 
705                 710                 715                 720 


Gln Ala His Arg Lys 
                725 


<210> 7899
<211> 93
<212> PRT
<213> Homo sapiens

<400> 7899
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu 
                85                  90              


<210> 7900
<211> 110
<212> PRT
<213> Homo sapiens

<400> 7900
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Thr Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Thr Ala His Glu Thr Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro 
            100                 105                 110 


<210> 7901
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7901
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Thr Ala Ile Arg Thr 
                85                  


<210> 7902
<211> 422
<212> PRT
<213> Homo sapiens

<400> 7902
Met Glu Arg Lys Asp Phe Glu Thr Trp Leu Asp Asn Ile Ser Val Thr 
1               5                   10                  15      


Phe Leu Ser Leu Thr Asp Leu Gln Lys Asn Glu Thr Leu Asp His Leu 
            20                  25                  30          


Ile Ser Leu Ser Gly Ala Val Gln Leu Arg His Leu Ser Asn Asn Leu 
        35                  40                  45              


Glu Thr Leu Leu Lys Arg Asp Phe Leu Lys Leu Leu Pro Leu Glu Leu 
    50                  55                  60                  


Ser Phe Tyr Leu Leu Lys Trp Leu Asp Pro Gln Thr Leu Leu Thr Cys 
65                  70                  75                  80  


Cys Leu Val Ser Lys Gln Trp Asn Lys Val Ile Ser Ala Cys Thr Glu 
                85                  90                  95      


Val Trp Gln Thr Ala Cys Lys Asn Leu Gly Trp Gln Ile Asp Asp Ser 
            100                 105                 110         


Val Gln Asp Ala Leu His Trp Lys Lys Val Tyr Leu Lys Ala Ile Leu 
        115                 120                 125             


Arg Met Lys Gln Leu Glu Asp His Glu Ala Phe Glu Thr Ser Ser Leu 
    130                 135                 140                 


Ile Gly His Ser Ala Arg Val Tyr Ala Leu Tyr Tyr Lys Asp Gly Leu 
145                 150                 155                 160 


Leu Cys Thr Gly Ser Asp Asp Leu Ser Ala Lys Leu Trp Asp Val Ser 
                165                 170                 175     


Thr Gly Gln Cys Val Tyr Gly Ile Gln Thr His Thr Cys Ala Ala Val 
            180                 185                 190         


Lys Phe Asp Glu Gln Lys Leu Val Thr Gly Ser Phe Asp Asn Thr Val 
        195                 200                 205             


Ala Cys Trp Glu Trp Ser Ser Gly Ala Arg Thr Gln His Phe Arg Gly 
    210                 215                 220                 


His Thr Gly Ala Val Phe Ser Val Asp Tyr Asn Asp Glu Leu Asp Ile 
225                 230                 235                 240 


Leu Val Ser Gly Ser Ala Asp Phe Thr Val Lys Val Trp Ala Leu Ser 
                245                 250                 255     


Ala Gly Thr Cys Leu Asn Thr Leu Thr Gly His Thr Glu Trp Val Thr 
            260                 265                 270         


Lys Val Val Leu Gln Lys Cys Lys Val Lys Ser Leu Leu His Ser Pro 
        275                 280                 285             


Gly Asp Tyr Ile Leu Leu Ser Ala Asp Lys Tyr Glu Ile Lys Ile Trp 
    290                 295                 300                 


Pro Ile Gly Arg Glu Ile Asn Cys Lys Cys Leu Lys Thr Leu Ser Val 
305                 310                 315                 320 


Ser Glu Asp Arg Ser Ile Cys Leu Gln Pro Arg Leu His Phe Asp Gly 
                325                 330                 335     


Lys Tyr Ile Val Cys Ser Ser Ala Leu Gly Leu Tyr Gln Trp Asp Phe 
            340                 345                 350         


Ala Ser Tyr Asp Ile Leu Arg Val Ile Lys Thr Pro Glu Ile Ala Asn 
        355                 360                 365             


Leu Ala Leu Leu Gly Phe Gly Asp Ile Phe Ala Leu Leu Phe Asp Asn 
    370                 375                 380                 


Arg Tyr Leu Tyr Ile Met Asp Leu Arg Thr Glu Ser Leu Ile Ser Arg 
385                 390                 395                 400 


Trp Pro Leu Pro Glu Tyr Arg Lys Ser Lys Arg Gly Ser Ser Phe Leu 
                405                 410                 415     


Ala Gly Glu His Pro Gly 
            420         


<210> 7903
<211> 392
<212> PRT
<213> Homo sapiens

<400> 7903
Met Ser Ala Leu Ala Gly Glu Asp Val Trp Arg Cys Pro Gly Cys Gly 
1               5                   10                  15      


Asp His Ile Ala Pro Ser Gln Ile Trp Tyr Arg Thr Val Asn Glu Thr 
            20                  25                  30          


Trp His Gly Ser Cys Phe Arg Arg Ser Asn Ser Ile Ser Lys Ser Pro 
        35                  40                  45              


Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu Phe Ser Arg Asp Ile Ser 
    50                  55                  60                  


Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser Tyr Ser Gln Gln Ile Phe 
65                  70                  75                  80  


Arg Pro Cys Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Phe Phe 
                85                  90                  95      


Gly Gln Ala Ile Lys Val Thr His Lys Ala Thr Gly Lys Val Met Val 
            100                 105                 110         


Met Lys Glu Leu Ile Arg Cys Asp Glu Glu Thr Gln Lys Thr Phe Leu 
        115                 120                 125             


Thr Glu Val Lys Val Met Arg Ser Leu Asp His Pro Asn Val Leu Lys 
    130                 135                 140                 


Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys Leu Asn Leu Leu Thr Glu 
145                 150                 155                 160 


Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe Leu Arg Ser Met Asp Pro 
                165                 170                 175     


Phe Pro Trp Gln Gln Lys Val Arg Phe Ala Lys Gly Ile Ala Ser Gly 
            180                 185                 190         


Met Ala Tyr Leu His Ser Met Cys Ile Ile His Arg Asp Leu Asn Ser 
        195                 200                 205             


His Asn Cys Leu Ile Lys Leu Asp Lys Thr Val Val Val Ala Asp Phe 
    210                 215                 220                 


Gly Leu Ser Arg Leu Ile Val Glu Glu Arg Lys Arg Ala Pro Met Glu 
225                 230                 235                 240 


Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg Lys Asn Asp Arg Lys Lys 
                245                 250                 255     


Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp Met Ala Pro Glu Met Leu 
            260                 265                 270         


Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp Ile Phe Ser Phe Gly Ile 
        275                 280                 285             


Val Leu Cys Glu Ile Ile Gly Gln Val Tyr Ala Asp Pro Asp Cys Leu 
    290                 295                 300                 


Pro Arg Thr Leu Asp Phe Gly Leu Asn Val Lys Leu Phe Trp Glu Lys 
305                 310                 315                 320 


Phe Val Pro Thr Asp Cys Pro Pro Ala Phe Phe Pro Leu Ala Ala Ile 
                325                 330                 335     


Cys Cys Arg Leu Glu Pro Glu Ser Arg Pro Ala Phe Ser Lys Leu Glu 
            340                 345                 350         


Asp Ser Phe Glu Ala Leu Ser Leu Tyr Leu Gly Glu Leu Gly Ile Pro 
        355                 360                 365             


Leu Pro Ala Glu Leu Glu Glu Leu Asp His Thr Val Ser Met Gln Tyr 
    370                 375                 380                 


Gly Leu Thr Arg Asp Ser Pro Pro 
385                 390         


<210> 7904
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7904
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Glu Lys Ile Leu Asn His Leu Ser Thr 
65                  70                  75                  80  


Leu Arg Arg Asp Arg Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu 
                85                  90                  95      


Ala Asp Ile Leu Ala Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr 
            100                 105                 110         


Ile Val Ala Glu Phe Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu 
        115                 120                 125             


Glu His Leu Leu Glu Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu 
    130                 135                 140                 


Gly Arg Glu Lys Phe Lys Ser Arg Gly Val Gly Glu Leu Ala Arg 
145                 150                 155                 


<210> 7905
<211> 1194
<212> PRT
<213> Homo sapiens

<400> 7905
Met Phe Ser Leu Asp Ser Phe Arg Lys Asp Arg Ala Gln His Arg Gln 
1               5                   10                  15      


Arg Gln Cys Lys Leu Pro Pro Pro Arg Leu Pro Pro Met Cys Val Asn 
            20                  25                  30          


Pro Thr Pro Gly Gly Thr Ile Ser Arg Ala Ser Arg Asp Leu Leu Lys 
        35                  40                  45              


Glu Phe Pro Gln Pro Lys Asn Leu Leu Asn Ser Val Ile Gly Arg Ala 
    50                  55                  60                  


Leu Gly Ile Ser His Ala Lys Asp Lys Leu Val Tyr Val His Thr Asn 
65                  70                  75                  80  


Gly Pro Lys Lys Lys Lys Val Thr Leu His Ile Lys Trp Pro Lys Ser 
                85                  90                  95      


Val Glu Val Glu Gly Tyr Gly Ser Lys Lys Ile Asp Ala Glu Arg Gln 
            100                 105                 110         


Ala Ala Ala Ala Ala Cys Gln Leu Phe Lys Gly Trp Gly Leu Leu Gly 
        115                 120                 125             


Pro Arg Asn Glu Leu Phe Asp Ala Ala Lys Tyr Arg Val Leu Ala Asp 
    130                 135                 140                 


Arg Phe Gly Ser Pro Ala Asp Ser Trp Trp Arg Pro Glu Pro Thr Met 
145                 150                 155                 160 


Pro Pro Thr Ser Trp Arg Gln Leu Asn Pro Glu Ser Ile Arg Pro Gly 
                165                 170                 175     


Gly Pro Gly Gly Leu Ser Arg Ser Leu Gly Arg Glu Glu Glu Glu Asp 
            180                 185                 190         


Glu Glu Glu Glu Leu Glu Glu Gly Thr Ile Asp Val Thr Asp Phe Leu 
        195                 200                 205             


Ser Met Thr Gln Gln Asp Ser His Ala Pro Leu Arg Asp Ser Arg Gly 
    210                 215                 220                 


Ser Ser Phe Glu Met Thr Asp Asp Asp Ser Ala Ile Arg Ala Leu Thr 
225                 230                 235                 240 


Gln Phe Pro Leu Pro Lys Asn Leu Leu Ala Lys Val Ile Gln Ile Ala 
                245                 250                 255     


Thr Ser Ser Ser Thr Ala Lys Asn Leu Met Gln Phe His Thr Val Gly 
            260                 265                 270         


Thr Lys Thr Lys Leu Ser Thr Leu Thr Leu Leu Trp Pro Cys Pro Met 
        275                 280                 285             


Thr Phe Val Ala Lys Gly Arg Arg Lys Ala Glu Ala Glu Asn Lys Ala 
    290                 295                 300                 


Ala Ala Leu Ala Cys Lys Lys Leu Lys Ser Leu Gly Leu Val Asp Arg 
305                 310                 315                 320 


Asn Asn Glu Pro Leu Thr His Ala Met Tyr Asn Leu Ala Ser Leu Arg 
                325                 330                 335     


Glu Leu Gly Glu Thr Gln Arg Arg Pro Cys Thr Ile Gln Val Pro Glu 
            340                 345                 350         


Pro Ile Leu Arg Lys Ile Glu Thr Phe Leu Asn His Tyr Pro Val Glu 
        355                 360                 365             


Ser Ser Trp Ile Ala Pro Glu Leu Arg Leu Gln Ser Asp Asp Ile Leu 
    370                 375                 380                 


Pro Leu Gly Lys Asp Ser Gly Pro Leu Ser Asp Pro Ile Thr Gly Lys 
385                 390                 395                 400 


Pro Tyr Val Pro Leu Leu Glu Ala Glu Glu Val Arg Leu Ser Gln Ser 
                405                 410                 415     


Leu Leu Glu Leu Trp Arg Arg Arg Gly Pro Val Trp Gln Glu Ala Pro 
            420                 425                 430         


Gln Leu Pro Val Asp Pro His Arg Asp Thr Ile Leu Asn Ala Ile Glu 
        435                 440                 445             


Gln His Pro Val Val Val Ile Ser Gly Asp Thr Gly Cys Gly Lys Thr 
    450                 455                 460                 


Thr Arg Ile Pro Gln Leu Leu Leu Glu Arg Tyr Val Thr Glu Gly Arg 
465                 470                 475                 480 


Gly Ala Arg Cys Asn Val Ile Ile Thr Gln Pro Arg Arg Ile Ser Ala 
                485                 490                 495     


Val Ser Val Ala Gln Arg Val Ser His Glu Leu Gly Pro Ser Leu Arg 
            500                 505                 510         


Arg Asn Val Gly Phe Gln Val Arg Leu Glu Ser Lys Pro Pro Ser Arg 
        515                 520                 525             


Gly Gly Ala Leu Leu Phe Cys Thr Val Gly Ile Leu Leu Arg Lys Leu 
    530                 535                 540                 


Gln Ser Asn Pro Ser Leu Glu Gly Val Ser His Val Ile Val Asp Glu 
545                 550                 555                 560 


Val His Glu Arg Asp Val Asn Thr Asp Phe Leu Leu Ile Leu Leu Lys 
                565                 570                 575     


Gly Leu Gln Arg Leu Asn Pro Ala Leu Arg Leu Val Leu Met Ser Ala 
            580                 585                 590         


Thr Gly Asp Asn Glu Arg Phe Ser Arg Tyr Phe Gly Gly Cys Pro Val 
        595                 600                 605             


Ile Lys Val Pro Gly Phe Met Tyr Pro Val Lys Glu His Tyr Leu Glu 
    610                 615                 620                 


Asp Ile Leu Ala Lys Leu Gly Lys His Gln Tyr Leu His Arg His Arg 
625                 630                 635                 640 


His His Glu Ser Glu Asp Glu Cys Ala Leu Asp Leu Asp Leu Val Thr 
                645                 650                 655     


Asp Leu Val Leu His Ile Asp Ala Arg Gly Glu Pro Gly Gly Ile Leu 
            660                 665                 670         


Cys Phe Leu Pro Gly Trp Gln Glu Ile Lys Gly Val Gln Gln Arg Leu 
        675                 680                 685             


Gln Glu Ala Leu Gly Met His Glu Ser Lys Tyr Leu Ile Leu Pro Val 
    690                 695                 700                 


His Ser Asn Ile Pro Met Met Asp Gln Lys Ala Ile Phe Gln Gln Pro 
705                 710                 715                 720 


Pro Val Gly Val Arg Lys Ile Val Leu Ala Thr Asn Ile Ala Glu Thr 
                725                 730                 735     


Ser Ile Thr Ile Asn Asp Ile Val His Val Val Asp Ser Gly Leu His 
            740                 745                 750         


Lys Glu Glu Arg Tyr Asp Leu Lys Thr Lys Val Ser Cys Leu Glu Thr 
        755                 760                 765             


Val Trp Val Ser Arg Ala Asn Val Ile Gln Arg Arg Gly Arg Ala Gly 
    770                 775                 780                 


Arg Cys Gln Ser Gly Phe Ala Tyr His Leu Phe Pro Arg Ser Arg Leu 
785                 790                 795                 800 


Glu Lys Met Val Pro Phe Gln Val Pro Glu Ile Leu Arg Thr Pro Leu 
                805                 810                 815     


Glu Asn Leu Val Leu Gln Ala Lys Ile His Met Pro Glu Lys Thr Ala 
            820                 825                 830         


Val Glu Phe Leu Ser Lys Ala Val Asp Ser Pro Asn Ile Lys Ala Val 
        835                 840                 845             


Asp Glu Ala Val Ile Leu Leu Gln Glu Ile Gly Val Leu Asp Gln Arg 
    850                 855                 860                 


Glu Tyr Leu Thr Thr Leu Gly Gln Arg Leu Ala His Ile Ser Thr Asp 
865                 870                 875                 880 


Pro Arg Leu Ala Lys Ala Ile Val Leu Ala Ala Ile Phe Arg Cys Leu 
                885                 890                 895     


His Pro Leu Leu Val Val Val Ser Cys Leu Thr Arg Asp Pro Phe Ser 
            900                 905                 910         


Ser Ser Leu Gln Asn Arg Ala Glu Val Asp Lys Val Lys Ala Leu Leu 
        915                 920                 925             


Ser His Asp Ser Gly Ser Asp His Leu Ala Phe Val Arg Ala Val Ala 
    930                 935                 940                 


Gly Trp Glu Glu Val Leu Arg Trp Gln Asp Arg Ser Ser Arg Glu Asn 
945                 950                 955                 960 


Tyr Leu Glu Glu Asn Leu Leu Tyr Ala Pro Ser Leu Arg Phe Ile His 
                965                 970                 975     


Gly Leu Ile Lys Gln Phe Ser Glu Asn Ile Tyr Glu Ala Phe Leu Val 
            980                 985                 990         


Gly Lys Pro Ser Asp Cys Thr Leu  Ala Ser Ala Gln Cys  Asn Glu Tyr 
        995                 1000                 1005             


Ser Glu  Glu Glu Glu Leu Val  Lys Gly Val Leu Met  Ala Gly Leu 
    1010                 1015                 1020             


Tyr Pro  Asn Leu Ile Gln Val  Arg Gln Gly Lys Val  Thr Arg Gln 
    1025                 1030                 1035             


Gly Lys  Phe Lys Pro Asn Ser  Val Thr Tyr Arg Thr  Lys Ser Gly 
    1040                 1045                 1050             


Asn Ile  Leu Leu His Lys Ser  Thr Ile Asn Arg Glu  Ala Thr Arg 
    1055                 1060                 1065             


Leu Arg  Ser Arg Trp Leu Thr  Tyr Phe Met Ala Val  Lys Ser Asn 
    1070                 1075                 1080             


Gly Ser  Val Phe Val Arg Asp  Ser Ser Gln Val His  Pro Leu Ala 
    1085                 1090                 1095             


Val Leu  Leu Leu Thr Asp Gly  Asp Val His Ile Arg  Asp Asp Gly 
    1100                 1105                 1110             


Arg Arg  Ala Thr Ile Ser Leu  Ser Asp Ser Asp Leu  Leu Arg Leu 
    1115                 1120                 1125             


Glu Gly  Asp Ser Arg Thr Val  Arg Leu Leu Lys Glu  Leu Arg Arg 
    1130                 1135                 1140             


Ala Leu  Gly Arg Met Val Glu  Arg Ser Leu Arg Ser  Glu Leu Ala 
    1145                 1150                 1155             


Ala Leu  Pro Pro Ser Val Gln  Glu Glu His Gly Gln  Leu Leu Ala 
    1160                 1165                 1170             


Leu Leu  Ala Glu Leu Leu Arg  Gly Pro Cys Gly Ser  Phe Asp Val 
    1175                 1180                 1185             


Arg Lys  Thr Ala Asp Asp 
    1190                 


<210> 7906
<211> 68
<212> PRT
<213> Homo sapiens

<400> 7906
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys 
65              


<210> 7907
<211> 472
<212> PRT
<213> Homo sapiens

<400> 7907
Met Ser Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Ala Ala Lys Ala Asp Gln Ala Tyr Glu Asp Ile Arg Val Ser Lys 
            20                  25                  30          


Val Thr Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Lys Phe Leu Ala 
        35                  40                  45              


Ile Ile Val Glu Ala Gly Gly Gly Gly Ala Phe Ile Val Leu Pro Leu 
    50                  55                  60                  


Ala Lys Thr Gly Arg Val Asp Lys Asn Tyr Pro Leu Val Thr Gly His 
65                  70                  75                  80  


Thr Ala Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Ala Ser Asp Asp Thr Thr Ile Met Val Trp Gln Ile Pro 
            100                 105                 110         


Asp Tyr Thr Pro Met Arg Asn Ile Thr Glu Pro Ile Ile Thr Leu Glu 
        115                 120                 125             


Gly His Ser Lys Arg Val Gly Ile Leu Ser Trp His Pro Thr Ala Arg 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Gly Asp Asn Val Ile Ile Ile Trp Asn 
145                 150                 155                 160 


Val Gly Thr Gly Glu Val Leu Leu Ser Leu Asp Asp Met His Pro Asp 
                165                 170                 175     


Val Ile His Ser Val Cys Trp Asn Ser Asn Gly Ser Leu Leu Ala Thr 
            180                 185                 190         


Thr Cys Lys Asp Lys Thr Leu Arg Ile Ile Asp Pro Arg Lys Gly Gln 
        195                 200                 205             


Val Val Ala Glu Gln Ala Arg Pro His Glu Gly Ala Arg Pro Leu Arg 
    210                 215                 220                 


Ala Val Phe Thr Ala Asp Gly Lys Leu Leu Ser Thr Gly Phe Ser Arg 
225                 230                 235                 240 


Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Asn Asn Phe Glu Glu 
                245                 250                 255     


Pro Val Ala Leu Gln Glu Met Asp Thr Ser Asn Gly Val Leu Leu Pro 
            260                 265                 270         


Phe Tyr Asp Pro Asp Ser Ser Ile Val Tyr Leu Cys Gly Lys Gly Asp 
        275                 280                 285             


Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp Glu Pro Pro Phe Val His 
    290                 295                 300                 


Tyr Leu Asn Thr Phe Ser Ser Lys Glu Pro Gln Arg Gly Met Gly Phe 
305                 310                 315                 320 


Met Pro Lys Arg Gly Leu Asp Val Ser Lys Cys Glu Ile Ala Arg Phe 
                325                 330                 335     


Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Ile Met Thr Val Pro 
            340                 345                 350         


Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Pro Gly 
        355                 360                 365             


Pro Glu Pro Ala Leu Glu Ala Asp Glu Trp Leu Ser Gly Gln Asp Ala 
    370                 375                 380                 


Glu Pro Val Leu Ile Ser Leu Arg Asp Gly Tyr Val Pro Pro Lys His 
385                 390                 395                 400 


Arg Glu Leu Arg Val Thr Lys Arg Asn Ile Leu Asp Val Arg Pro Pro 
                405                 410                 415     


Ser Gly Pro Arg Arg Ser Gln Ser Ala Ser Asp Ala Pro Leu Ser Gln 
            420                 425                 430         


Gln His Thr Leu Glu Thr Leu Leu Glu Glu Ile Lys Ala Leu Arg Glu 
        435                 440                 445             


Arg Val Gln Ala Gln Glu Gln Arg Ile Thr Ala Leu Glu Asn Met Leu 
    450                 455                 460                 


Cys Glu Leu Val Asp Gly Thr Asp 
465                 470         


<210> 7908
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7908
Ile Leu His Ser Leu Val Gln Thr Gly Ile Cys Val Ile Thr Leu Ala 
1               5                   10                  15      


Glu Ser His Pro Val Leu Gln Ser Gly Lys Thr Ile Lys Ser Ile Ser 
            20                  25                  30          


Tyr Gln Ile Ser Thr Asn Cys Ser Arg Leu Gln Asn Lys Val Ser Gly 
        35                  40                  45              


Lys Phe Lys Arg Gly Ala Gln Phe Leu Thr Glu Leu Ala Pro Leu Cys 
    50                  55                  60                  


Lys Ile Tyr Cys Ser Asp Gly Glu Glu Tyr Thr Val Ser Ser Cys Val 
65                  70                  75                  80  


Arg Gly Arg Leu Met Glu Val Asn Glu Asn Ile Leu His Lys Pro Ser 
                85                  90                  95      


Ile Leu Gln Glu Lys Pro Ser Thr Glu Gly Tyr Ile Ala Val Val Leu 
            100                 105                 110         


Pro Lys Phe Glu Glu Ser Lys Ser Ile Thr Glu Gly Leu Leu Thr Gln 
        115                 120                 125             


Lys 
    


<210> 7909
<211> 244
<212> PRT
<213> Homo sapiens

<400> 7909
Met Val His Gln Asp Asn Cys Ser Tyr Gln Ala Gln Lys Asn Glu Arg 
1               5                   10                  15      


Glu Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe Phe Asp Asp Gly 
            20                  25                  30          


Pro Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys Pro Ser Leu Ser 
        35                  40                  45              


Ser Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys Phe Val Asn Asp 
    50                  55                  60                  


Ser Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser Lys Thr Glu Thr 
65                  70                  75                  80  


Ser Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln Ser Ser Ser Tyr 
                85                  90                  95      


Ser Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser Leu Asp Asp Met 
            100                 105                 110         


Asp Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu Ala Lys Met Ala 
        115                 120                 125             


Leu Ala Met Ala Lys Pro Met Ala Lys Met Gln Val Glu Val Glu Lys 
    130                 135                 140                 


Gln Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu Pro His Met Pro 
145                 150                 155                 160 


His Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys Pro Thr Asp Leu 
                165                 170                 175     


Arg Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val Asn Asp Leu His 
            180                 185                 190         


Ser Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln Leu Leu Leu Ile 
        195                 200                 205             


Arg Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu Val Asp Ile Glu 
    210                 215                 220                 


Asp Leu Thr Arg His Ala Glu Ser Gln Gln Lys His Met Ala Glu Lys 
225                 230                 235                 240 


Met Pro Ala Lys 
                


<210> 7910
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7910
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7911
<211> 146
<212> PRT
<213> Homo sapiens

<400> 7911
Met Phe Glu Ile Leu Thr Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
1               5                   10                  15      


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Thr Val 
            20                  25                  30          


Thr Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
        35                  40                  45              


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
    50                  55                  60                  


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
65                  70                  75                  80  


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
                85                  90                  95      


Gln Arg Thr Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
            100                 105                 110         


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
        115                 120                 125             


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Thr Arg Leu Pro Leu 
    130                 135                 140                 


Leu Met 
145     


<210> 7912
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7912
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7913
<211> 100
<212> PRT
<213> Homo sapiens

<400> 7913
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp 
                85                  90                  95      


Trp Tyr Lys Thr 
            100 


<210> 7914
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7914
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7915
<211> 210
<212> PRT
<213> Homo sapiens

<400> 7915
Met Val Ser Met Ser Val Pro Asp Cys Leu Ser Ile Met Thr Tyr Val 
1               5                   10                  15      


Ser Gln Tyr Tyr Asn His Phe Cys Ser Pro Gly Gln Ala Gly Val Ser 
            20                  25                  30          


Pro Pro Arg Lys Gly Leu Ala Pro Cys Ser Pro Pro Ser Val Ala Pro 
        35                  40                  45              


Thr Pro Val Glu Pro Glu Asp Val Ala Gln Gly Glu Glu Leu Ser Ser 
    50                  55                  60                  


Gly Ser Leu Ser Glu Gln Gly Thr Gly Gln Thr Pro Ser Ser Thr Cys 
65                  70                  75                  80  


Ala Ala Cys Gln Gln His Val His Leu Val Gln Arg Tyr Leu Ala Asp 
                85                  90                  95      


Gly Arg Leu Tyr His Arg His Cys Phe Arg Cys Arg Arg Cys Ser Ser 
            100                 105                 110         


Thr Leu Leu Pro Gly Ala Tyr Glu Asn Gly Pro Glu Glu Gly Thr Phe 
        115                 120                 125             


Val Cys Ala Glu His Cys Ala Arg Leu Gly Pro Gly Thr Arg Ser Gly 
    130                 135                 140                 


Thr Arg Pro Gly Pro Phe Ser Gln Pro Lys Gln Gln His Gln Gln Gln 
145                 150                 155                 160 


Leu Ala Glu Asp Ala Lys Asp Val Pro Gly Gly Gly Pro Ser Ser Ser 
                165                 170                 175     


Ala Pro Ala Gly Ala Glu Ala Asp Gly Pro Lys Ala Ser Pro Glu Ala 
            180                 185                 190         


Arg Pro Gln Ile Pro Thr Lys Pro Arg Val Pro Gly Lys Leu Gln Glu 
        195                 200                 205             


Leu Ala 
    210 


<210> 7916
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7916
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7917
<211> 206
<212> PRT
<213> Homo sapiens

<400> 7917
Met Ala Leu Asn Val Ala Pro Val Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Gln Phe Gln Arg Gly Thr Cys Ser Arg Ser Asp Glu 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Pro Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Thr His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Thr Ala Ala Ala Met 
                85                  90                  95      


Leu Ala Gln Gln Met Gln Phe Met Phe Pro Gly Thr Pro Leu His Pro 
            100                 105                 110         


Val Ala Phe Pro Pro Gly Ala Leu His Pro Leu Pro Lys Arg Gln Ala 
        115                 120                 125             


Leu Glu Lys Ser Asn Gly Thr Ser Ala Val Phe Asn Pro Ser Val Leu 
    130                 135                 140                 


His Tyr Gln Gln Ala Leu Thr Ser Ala Gln Leu Gln Gln His Ala Ala 
145                 150                 155                 160 


Phe Ile Pro Thr Asp Asn Ser Glu Ile Ile Ser Arg Asn Gly Met Glu 
                165                 170                 175     


Cys Gln Glu Ser Ala Leu Arg Ile Thr Lys His Cys Tyr Cys Thr Tyr 
            180                 185                 190         


Tyr Pro Val Ser Ser Ser Ile Glu Leu Pro Gln Thr Ala Cys 
        195                 200                 205     


<210> 7918
<211> 325
<212> PRT
<213> Homo sapiens

<400> 7918
Met Gln Gln Pro Val Arg Ala Gly Asp Ile Gly Val Ser Arg Val Gln 
1               5                   10                  15      


Thr His His Asn Ala Ser Pro Phe Ser Val Pro Lys Lys Gln Asp Glu 
            20                  25                  30          


Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu Ser Leu Phe Gly 
        35                  40                  45              


Asp Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr Gln Lys Thr Leu 
    50                  55                  60                  


Lys Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln Phe Thr Ser Ser 
65                  70                  75                  80  


Ser Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val Lys Gly Leu Phe 
                85                  90                  95      


Val Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met Ala Ile Gly Asp 
            100                 105                 110         


His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile Ser Leu Tyr Arg 
        115                 120                 125             


Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr Val Thr Val Trp 
    130                 135                 140                 


Ala Ala Ala Ser Glu Ala Lys His Gln Pro Pro Ser Asp Phe Leu Trp 
145                 150                 155                 160 


Lys Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu 
                165                 170                 175     


Cys Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp 
            180                 185                 190         


Lys Gln Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys 
        195                 200                 205             


Ser Val Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala 
    210                 215                 220                 


Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp 
225                 230                 235                 240 


Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu 
                245                 250                 255     


Lys Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln 
            260                 265                 270         


Asn Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His 
        275                 280                 285             


Asn Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg 
    290                 295                 300                 


Ser Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser 
305                 310                 315                 320 


Glu Ser Gln Lys Gln 
                325 


<210> 7919
<211> 418
<212> PRT
<213> Homo sapiens

<400> 7919
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Thr Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ala Gly Gly Tyr Val Gly Asp Ser Ala Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ser Ser Ser Gln Lys Tyr Val Pro Arg Ala Ala 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Asn Asn Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly 
            100                 105                 110         


Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg 
        115                 120                 125             


Glu Glu Phe Pro Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser 
    130                 135                 140                 


Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser 
145                 150                 155                 160 


Val His Gln Leu Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn 
                165                 170                 175     


Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro 
            180                 185                 190         


Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val 
        195                 200                 205             


Thr Thr Ser Leu Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys 
    210                 215                 220                 


Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro 
225                 230                 235                 240 


Gly Phe Ala Pro Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu 
                245                 250                 255     


Thr Val Pro Glu Leu Thr Gln Gln Met Phe Asp Ala Arg Asn Met Met 
            260                 265                 270         


Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val 
        275                 280                 285             


Phe Arg Gly Pro Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala 
    290                 295                 300                 


Ile Gln Ser Lys Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn 
305                 310                 315                 320 


Val Lys Val Ala Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala 
                325                 330                 335     


Ser Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg 
            340                 345                 350         


Ile Ser Glu Gln Phe Ser Ala Met Phe Arg Arg Lys Ala Phe Leu His 
        355                 360                 365             


Trp Phe Thr Gly Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu 
    370                 375                 380                 


Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala 
385                 390                 395                 400 


Thr Ala Asn Asp Gly Glu Glu Ala Phe Glu Asp Glu Glu Glu Glu Ile 
                405                 410                 415     


Asp Gly 
        


<210> 7920
<211> 89
<212> PRT
<213> Homo sapiens

<400> 7920
Met Asp Val Leu Ser Pro Leu Ser Phe Ile Lys Val Ser His Val Arg 
1               5                   10                  15      


Met Gln Gly Ile Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro 
            20                  25                  30          


Tyr Ile Gln Ile Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly 
        35                  40                  45              


Tyr Trp Gly Asn Lys Gly Gly Val Asn Ile Cys Leu Lys Leu Tyr Gly 
    50                  55                  60                  


Tyr Tyr Val Ser Ile Ile Asn Cys His Leu Pro Pro His Ile Ser Asn 
65                  70                  75                  80  


Asn Tyr Gln Arg Leu Glu His Phe Asp 
                85                  


<210> 7921
<211> 59
<212> PRT
<213> Homo sapiens

<400> 7921
Met Thr Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Gln Ser Asp Ser Val Lys Gly Lys Arg Arg Asp Asp Gly Leu Ser 
            20                  25                  30          


Ala Ala Ala Arg Lys Gln Arg Asp Ser Glu Ile Met Gln Gln Lys Gln 
        35                  40                  45              


Lys Lys Ala Asn Glu Lys Lys Glu Glu Pro Lys 
    50                  55                  


<210> 7922
<211> 287
<212> PRT
<213> Homo sapiens

<400> 7922
Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly Ser Val 
1               5                   10                  15      


Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys Gly Tyr 
            20                  25                  30          


Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile Val Gly 
        35                  40                  45              


Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro Ala Ile 
    50                  55                  60                  


Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro Leu Val 
65                  70                  75                  80  


Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg Asn Pro 
                85                  90                  95      


Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro Val Thr 
            100                 105                 110         


Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly Gln Val 
        115                 120                 125             


Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr Pro Thr 
    130                 135                 140                 


Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu Pro Val 
145                 150                 155                 160 


Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe Gln Val 
                165                 170                 175     


Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala 
            180                 185                 190         


Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe Pro Val 
        195                 200                 205             


Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val 
    210                 215                 220                 


Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala 
225                 230                 235                 240 


Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe Pro Val 
                245                 250                 255     


Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val Gln Val 
            260                 265                 270         


Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Lys Phe Pro 
        275                 280                 285         


<210> 7923
<211> 447
<212> PRT
<213> Homo sapiens

<400> 7923
Met Asp Met Gly Asn Gln His Pro Ser Ile Ser Arg Leu Gln Glu Ile 
1               5                   10                  15      


Gln Lys Glu Val Lys Ser Val Glu Gln Gln Val Ile Gly Phe Ser Gly 
            20                  25                  30          


Leu Ser Asp Asp Lys Asn Tyr Lys Lys Leu Glu Arg Ile Leu Thr Lys 
        35                  40                  45              


Gln Leu Phe Glu Ile Asp Ser Val Asp Thr Glu Gly Lys Gly Asp Ile 
    50                  55                  60                  


Gln Gln Ala Arg Lys Arg Ala Ala Gln Glu Thr Glu Arg Leu Leu Lys 
65                  70                  75                  80  


Glu Leu Glu Gln Asn Ala Asn His Pro His Arg Ile Glu Ile Gln Asn 
                85                  90                  95      


Ile Phe Glu Glu Ala Gln Ser Leu Val Arg Glu Lys Ile Val Pro Phe 
            100                 105                 110         


Tyr Asn Gly Gly Asn Cys Val Thr Asp Glu Phe Glu Glu Gly Ile Gln 
        115                 120                 125             


Asp Ile Ile Leu Arg Leu Thr His Val Lys Thr Gly Gly Lys Ile Ser 
    130                 135                 140                 


Leu Arg Lys Ala Arg Tyr His Thr Leu Thr Lys Ile Cys Ala Val Gln 
145                 150                 155                 160 


Glu Ile Ile Glu Asp Cys Met Lys Lys Gln Pro Ser Leu Pro Leu Ser 
                165                 170                 175     


Glu Asp Ala His Pro Ser Val Ala Lys Ile Asn Phe Val Met Cys Glu 
            180                 185                 190         


Val Asn Lys Ala Arg Gly Val Leu Ile Ala Leu Leu Met Gly Val Asn 
        195                 200                 205             


Asn Asn Glu Thr Cys Arg His Leu Ser Cys Val Leu Ser Gly Leu Ile 
    210                 215                 220                 


Ala Asp Leu Asp Ala Leu Asp Val Cys Gly Arg Thr Glu Ile Arg Asn 
225                 230                 235                 240 


Tyr Arg Arg Glu Val Val Glu Asp Ile Asn Lys Leu Leu Lys Tyr Leu 
                245                 250                 255     


Asp Leu Glu Glu Glu Ala Asp Thr Thr Lys Ala Phe Asp Leu Arg Gln 
            260                 265                 270         


Asn His Ser Ile Leu Lys Ile Glu Lys Val Leu Lys Arg Met Arg Glu 
        275                 280                 285             


Ile Lys Asn Glu Leu Leu Gln Ala Gln Asn Pro Ser Glu Leu Tyr Leu 
    290                 295                 300                 


Ser Ser Lys Thr Glu Leu Gln Gly Leu Ile Gly Gln Leu Asp Glu Val 
305                 310                 315                 320 


Ser Leu Glu Lys Asn Pro Cys Ile Arg Glu Ala Arg Arg Arg Ala Val 
                325                 330                 335     


Ile Glu Val Gln Thr Leu Ile Thr Tyr Ile Asp Leu Lys Glu Ala Leu 
            340                 345                 350         


Glu Lys Arg Lys Leu Phe Ala Cys Glu Glu His Pro Ser His Lys Ala 
        355                 360                 365             


Val Trp Asn Val Leu Gly Asn Leu Ser Glu Ile Gln Gly Glu Val Leu 
    370                 375                 380                 


Ser Phe Asp Gly Asn Arg Thr Asp Lys Asn Tyr Ile Arg Leu Glu Glu 
385                 390                 395                 400 


Leu Leu Thr Lys Gln Leu Leu Ala Leu Asp Ala Val Asp Pro Gln Gly 
                405                 410                 415     


Glu Glu Lys Cys Lys Ala Ala Arg Lys Gln Ala Val Arg Leu Ala Gln 
            420                 425                 430         


Asn Ile Leu Ser Tyr Leu Asp Leu Lys Ser Asp Glu Trp Glu Tyr 
        435                 440                 445         


<210> 7924
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7924
Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      


Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val 
            20                  25                  30          


Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp 
        35                  40                  45              


Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu 
    50                  55                  60                  


Thr Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp 
65                  70                  75                  80  


His Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu 
                85                  90                  95      


Lys Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser 
            100                 105                 110         


Leu Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala 
        115                 120                 125             


Val Val Ala Asn Gln Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser 
    130                 135                 140                 


Trp Asp Val Glu Thr Ala Thr Glu Leu Leu Leu Ser Asn 
145                 150                 155         


<210> 7925
<211> 193
<212> PRT
<213> Homo sapiens

<400> 7925
Met Pro Thr Thr Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Thr Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser 
    50                  55                  60                  


Ser Gly Ser Pro Ile Gly Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro 
65                  70                  75                  80  


Pro Ser Phe Asn Leu His Pro Ala Pro His Leu Leu Ala Ser Met His 
                85                  90                  95      


Leu Gln Lys Leu Asn Ser Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro 
            100                 105                 110         


Gly Gln Pro Gly Glu Ala Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala 
        115                 120                 125             


Gln Ala Gly Gly Ala Glu Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser 
    130                 135                 140                 


Pro Ala Ile Ile Asp Ser Asp Pro Val Asp Glu Glu Val Leu Met Ser 
145                 150                 155                 160 


Leu Val Val Glu Leu Gly Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu 
                165                 170                 175     


Trp Leu Gly Gln Asn Glu Phe Asp Phe Thr Ala Asp Phe Pro Ser Ser 
            180                 185                 190         


Cys 
    


<210> 7926
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7926
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210> 7927
<211> 207
<212> PRT
<213> Homo sapiens

<400> 7927
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala 
        35                  40                  45              


Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala 
    50                  55                  60                  


Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro 
                85                  90                  95      


Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys 
            100                 105                 110         


Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr 
        115                 120                 125             


Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro 
    130                 135                 140                 


Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr 
                165                 170                 175     


Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser 
            180                 185                 190         


Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile 
        195                 200                 205         


<210> 7928
<211> 467
<212> PRT
<213> Homo sapiens

<400> 7928
Met Ala Ser Leu Leu Gln Ser Asp Arg Val Leu Tyr Leu Val Gln Gly 
1               5                   10                  15      


Glu Lys Lys Val Arg Ala Pro Leu Ser Gln Leu Tyr Phe Cys Arg Tyr 
            20                  25                  30          


Cys Ser Glu Leu Arg Ser Leu Glu Cys Val Ser His Glu Val Asp Ser 
        35                  40                  45              


His Tyr Cys Pro Ser Cys Leu Glu Asn Met Pro Ser Ala Glu Ala Lys 
    50                  55                  60                  


Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe Asp Cys Pro Gly Cys Met 
65                  70                  75                  80  


His Thr Leu Ser Thr Arg Ala Thr Ser Ile Ser Thr Gln Leu Pro Asp 
                85                  90                  95      


Asp Pro Ala Lys Thr Thr Met Lys Lys Ala Tyr Tyr Leu Ala Cys Gly 
            100                 105                 110         


Phe Cys Arg Trp Thr Ser Arg Asp Val Gly Met Ala Asp Lys Ser Val 
        115                 120                 125             


Ala Ser Gly Gly Trp Gln Glu Pro Glu Asn Pro His Thr Gln Arg Met 
    130                 135                 140                 


Asn Lys Leu Ile Glu Tyr Tyr Gln Gln Leu Ala Gln Lys Glu Lys Val 
145                 150                 155                 160 


Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg Arg Asn Tyr Met Pro Leu 
                165                 170                 175     


Ala Phe Ser Gln His Thr Ile His Val Val Asp Lys Tyr Gly Leu Gly 
            180                 185                 190         


Thr Arg Leu Gln Arg Pro Arg Ala Gly Ala Ser Ile Ser Thr Leu Ala 
        195                 200                 205             


Gly Leu Ser Leu Lys Glu Gly Glu Asp Gln Lys Glu Ile Lys Ile Glu 
    210                 215                 220                 


Pro Ala Gln Ala Val Asp Glu Val Glu Pro Leu Pro Glu Asp Tyr Tyr 
225                 230                 235                 240 


Thr Arg Pro Val Asn Leu Thr Glu Val Thr Thr Leu Gln Gln Arg Leu 
                245                 250                 255     


Leu Gln Pro Asp Phe Gln Pro Val Cys Ala Ser Gln Leu Tyr Pro Arg 
            260                 265                 270         


His Lys His Leu Leu Ile Lys Arg Ser Leu Arg Cys Arg Lys Cys Glu 
        275                 280                 285             


His Asn Leu Ser Lys Pro Glu Phe Asn Pro Thr Ser Ile Lys Phe Lys 
    290                 295                 300                 


Ile Gln Leu Val Ala Val Asn Tyr Ile Pro Glu Val Arg Ile Met Ser 
305                 310                 315                 320 


Ile Pro Asn Leu Arg Tyr Met Lys Glu Ser Gln Val Leu Leu Thr Leu 
                325                 330                 335     


Thr Asn Pro Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu 
            340                 345                 350         


Glu Gly Asp Pro Asp Asp Ile Asn Ser Thr Ala Lys Val Val Val Pro 
        355                 360                 365             


Pro Lys Glu Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp 
    370                 375                 380                 


Glu Leu Ala Glu Pro Gln Asp Phe Gln Asp Asp Pro Asp Ile Ile Ala 
385                 390                 395                 400 


Phe Arg Lys Ala Asn Lys Val Gly Ile Phe Ile Lys Val Thr Pro Gln 
                405                 410                 415     


Arg Glu Glu Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe 
            420                 425                 430         


Lys Asn Leu Ala Ala Pro Ile Arg Pro Ile Glu Glu Ser Asp Gln Gly 
        435                 440                 445             


Thr Glu Val Ile Trp Leu Thr Gln His Val Glu Leu Ser Leu Gly Pro 
    450                 455                 460                 


Leu Leu Pro 
465         


<210> 7929
<211> 144
<212> PRT
<213> Homo sapiens

<400> 7929
Val Arg Glu Leu Glu Ala Glu Leu Asp Ala Glu Gln Lys Lys His Ala 
1               5                   10                  15      


Glu Ala Leu Lys Gly Val Arg Lys His Glu Arg Arg Val Lys Glu Leu 
            20                  25                  30          


Ala Tyr Gln Ala Glu Glu Asp Arg Lys Asn Leu Ala Arg Met Gln Asp 
        35                  40                  45              


Leu Val Asp Lys Leu Gln Ser Lys Val Lys Ser Tyr Lys Arg Gln Phe 
    50                  55                  60                  


Glu Glu Ala Val Ser Ala Leu Gly Pro Gly His Leu Asp Arg Ala Pro 
65                  70                  75                  80  


Gln Leu Cys Pro Arg Val Cys Gly Gln Glu Gln Gln Ala Asn Thr Asn 
                85                  90                  95      


Leu Ala Lys Tyr Arg Lys Ala Gln His Glu Leu Asp Asp Ala Glu Glu 
            100                 105                 110         


Arg Ala Asp Met Ala Glu Thr Gln Ala Asn Lys Leu Arg Ala Arg Thr 
        115                 120                 125             


Arg Asp Ala Leu Gly Pro Lys Leu Ser Leu Ser Pro Gln His Lys Glu 
    130                 135                 140                 


<210> 7930
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7930
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 7931
<211> 1155
<212> PRT
<213> Homo sapiens

<400> 7931
Met Ala Ala Ser Arg Asp Leu Leu Lys Glu Phe Pro Gln Pro Lys Asn 
1               5                   10                  15      


Leu Leu Asn Ser Val Ile Gly Arg Ala Leu Gly Ile Ser His Ala Lys 
            20                  25                  30          


Asp Lys Leu Val Tyr Val His Thr Asn Gly Pro Lys Lys Lys Lys Val 
        35                  40                  45              


Thr Leu His Ile Lys Trp Pro Lys Ser Val Glu Val Glu Gly Tyr Gly 
    50                  55                  60                  


Ser Lys Lys Ile Asp Ala Glu Arg Gln Ala Ala Ala Ala Ala Cys Gln 
65                  70                  75                  80  


Leu Phe Lys Gly Trp Gly Leu Leu Gly Pro Arg Asn Glu Leu Phe Asp 
                85                  90                  95      


Ala Ala Lys Tyr Arg Val Leu Ala Asp Arg Phe Gly Ser Pro Ala Asp 
            100                 105                 110         


Ser Trp Trp Arg Pro Glu Pro Thr Met Pro Pro Thr Ser Trp Arg Gln 
        115                 120                 125             


Leu Asn Pro Glu Ser Ile Arg Pro Gly Gly Pro Gly Gly Leu Ser Arg 
    130                 135                 140                 


Ser Leu Gly Arg Glu Glu Glu Glu Asp Glu Glu Glu Glu Leu Glu Glu 
145                 150                 155                 160 


Gly Thr Ile Asp Val Thr Asp Phe Leu Ser Met Thr Gln Gln Asp Ser 
                165                 170                 175     


His Ala Pro Leu Arg Asp Ser Arg Gly Ser Ser Phe Glu Met Thr Asp 
            180                 185                 190         


Asp Asp Ser Ala Ile Arg Ala Leu Thr Gln Phe Pro Leu Pro Lys Asn 
        195                 200                 205             


Leu Leu Ala Lys Val Ile Gln Ile Ala Thr Ser Ser Ser Thr Ala Lys 
    210                 215                 220                 


Asn Leu Met Gln Phe His Thr Val Gly Thr Lys Thr Lys Leu Ser Thr 
225                 230                 235                 240 


Leu Thr Leu Leu Trp Pro Cys Pro Met Thr Phe Val Ala Lys Gly Arg 
                245                 250                 255     


Arg Lys Ala Glu Ala Glu Asn Lys Ala Ala Ala Leu Ala Cys Lys Lys 
            260                 265                 270         


Leu Lys Ser Leu Gly Leu Val Asp Arg Asn Asn Glu Pro Leu Thr His 
        275                 280                 285             


Ala Met Tyr Asn Leu Ala Ser Leu Arg Glu Leu Gly Glu Thr Gln Arg 
    290                 295                 300                 


Arg Pro Cys Thr Ile Gln Val Pro Glu Pro Ile Leu Arg Lys Ile Glu 
305                 310                 315                 320 


Thr Phe Leu Asn His Tyr Pro Val Glu Ser Ser Trp Ile Ala Pro Glu 
                325                 330                 335     


Leu Arg Leu Gln Ser Asp Asp Ile Leu Pro Leu Gly Lys Asp Ser Gly 
            340                 345                 350         


Pro Leu Ser Asp Pro Ile Thr Gly Lys Pro Tyr Val Pro Leu Leu Glu 
        355                 360                 365             


Ala Glu Glu Val Arg Leu Ser Gln Ser Leu Leu Glu Leu Trp Arg Arg 
    370                 375                 380                 


Arg Gly Pro Val Trp Gln Glu Ala Pro Gln Leu Pro Val Asp Pro His 
385                 390                 395                 400 


Arg Asp Thr Ile Leu Asn Ala Ile Glu Gln His Pro Val Val Val Ile 
                405                 410                 415     


Ser Gly Asp Thr Gly Cys Gly Lys Thr Thr Arg Ile Pro Gln Leu Leu 
            420                 425                 430         


Leu Glu Arg Tyr Val Thr Glu Gly Arg Gly Ala Arg Cys Asn Val Ile 
        435                 440                 445             


Ile Thr Gln Pro Arg Arg Ile Ser Ala Val Ser Val Ala Gln Arg Val 
    450                 455                 460                 


Ser His Glu Leu Gly Pro Ser Leu Arg Arg Asn Val Gly Phe Gln Val 
465                 470                 475                 480 


Arg Leu Glu Ser Lys Pro Pro Ser Arg Gly Gly Ala Leu Leu Phe Cys 
                485                 490                 495     


Thr Val Gly Ile Leu Leu Arg Lys Leu Gln Ser Asn Pro Ser Leu Glu 
            500                 505                 510         


Gly Val Ser His Val Ile Val Asp Glu Val His Glu Arg Asp Val Asn 
        515                 520                 525             


Thr Asp Phe Leu Leu Ile Leu Leu Lys Gly Leu Gln Arg Leu Asn Pro 
    530                 535                 540                 


Ala Leu Arg Leu Val Leu Met Ser Ala Thr Gly Asp Asn Glu Arg Phe 
545                 550                 555                 560 


Ser Arg Tyr Phe Gly Gly Cys Pro Val Ile Lys Val Pro Gly Phe Met 
                565                 570                 575     


Tyr Pro Val Lys Glu His Tyr Leu Glu Asp Ile Leu Ala Lys Leu Gly 
            580                 585                 590         


Lys His Gln Tyr Leu His Arg His Arg His His Glu Ser Glu Asp Glu 
        595                 600                 605             


Cys Ala Leu Asp Leu Asp Leu Val Thr Asp Leu Val Leu His Ile Asp 
    610                 615                 620                 


Ala Arg Gly Glu Pro Gly Gly Ile Leu Cys Phe Leu Pro Gly Trp Gln 
625                 630                 635                 640 


Glu Ile Lys Gly Val Gln Gln Arg Leu Gln Glu Ala Leu Gly Met His 
                645                 650                 655     


Glu Ser Lys Tyr Leu Ile Leu Pro Val His Ser Asn Ile Pro Met Met 
            660                 665                 670         


Asp Gln Lys Ala Ile Phe Gln Gln Pro Pro Val Gly Val Arg Lys Ile 
        675                 680                 685             


Val Leu Ala Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile Asn Asp Ile 
    690                 695                 700                 


Val His Val Val Asp Ser Gly Leu His Lys Glu Glu Arg Tyr Asp Leu 
705                 710                 715                 720 


Lys Thr Lys Val Ser Cys Leu Glu Thr Val Trp Val Ser Arg Ala Asn 
                725                 730                 735     


Val Ile Gln Arg Arg Gly Arg Ala Gly Arg Cys Gln Ser Gly Phe Ala 
            740                 745                 750         


Tyr His Leu Phe Pro Arg Ser Arg Leu Glu Lys Met Val Pro Phe Gln 
        755                 760                 765             


Val Pro Glu Ile Leu Arg Thr Pro Leu Glu Asn Leu Val Leu Gln Ala 
    770                 775                 780                 


Lys Ile His Met Pro Glu Lys Thr Ala Val Glu Phe Leu Ser Lys Ala 
785                 790                 795                 800 


Val Asp Ser Pro Asn Ile Lys Ala Val Asp Glu Ala Val Ile Leu Leu 
                805                 810                 815     


Gln Glu Ile Gly Val Leu Asp Gln Arg Glu Tyr Leu Thr Thr Leu Gly 
            820                 825                 830         


Gln Arg Leu Ala His Ile Ser Thr Asp Pro Arg Leu Ala Lys Ala Ile 
        835                 840                 845             


Val Leu Ala Ala Ile Phe Arg Cys Leu His Pro Leu Leu Val Val Val 
    850                 855                 860                 


Ser Cys Leu Thr Arg Asp Pro Phe Ser Ser Ser Leu Gln Asn Arg Ala 
865                 870                 875                 880 


Glu Val Asp Lys Val Lys Ala Leu Leu Ser His Asp Ser Gly Ser Asp 
                885                 890                 895     


His Leu Ala Phe Val Arg Ala Val Ala Gly Trp Glu Glu Val Leu Arg 
            900                 905                 910         


Trp Gln Asp Arg Ser Ser Arg Glu Asn Tyr Leu Glu Glu Asn Leu Leu 
        915                 920                 925             


Tyr Ala Pro Ser Leu Arg Phe Ile His Gly Leu Ile Lys Gln Phe Ser 
    930                 935                 940                 


Glu Asn Ile Tyr Glu Ala Phe Leu Val Gly Lys Pro Ser Asp Cys Thr 
945                 950                 955                 960 


Leu Ala Ser Ala Gln Cys Asn Glu Tyr Ser Glu Glu Glu Glu Leu Val 
                965                 970                 975     


Lys Gly Val Leu Met Ala Gly Leu Tyr Pro Asn Leu Ile Gln Val Arg 
            980                 985                 990         


Gln Gly Lys Val Thr Arg Gln Gly  Lys Phe Lys Pro Asn  Ser Val Thr 
        995                 1000                 1005             


Tyr Arg  Thr Lys Ser Gly Asn  Ile Leu Leu His Lys  Ser Thr Ile 
    1010                 1015                 1020             


Asn Arg  Glu Ala Thr Arg Leu  Arg Ser Arg Trp Leu  Thr Tyr Phe 
    1025                 1030                 1035             


Met Ala  Val Lys Ser Asn Gly  Ser Val Phe Val Arg  Asp Ser Ser 
    1040                 1045                 1050             


Gln Val  His Pro Leu Ala Val  Leu Leu Leu Thr Asp  Gly Asp Val 
    1055                 1060                 1065             


His Ile  Arg Asp Asp Gly Arg  Arg Ala Thr Ile Ser  Leu Ser Asp 
    1070                 1075                 1080             


Ser Asp  Leu Leu Arg Leu Glu  Gly Asp Ser Arg Thr  Val Arg Leu 
    1085                 1090                 1095             


Leu Lys  Glu Leu Arg Arg Ala  Leu Gly Arg Met Val  Glu Arg Ser 
    1100                 1105                 1110             


Leu Arg  Ser Glu Leu Ala Ala  Leu Pro Pro Ser Val  Gln Glu Glu 
    1115                 1120                 1125             


His Gly  Gln Leu Leu Ala Leu  Leu Ala Glu Leu Leu  Arg Gly Pro 
    1130                 1135                 1140             


Cys Gly  Ser Phe Asp Val Arg  Lys Thr Ala Asp Asp  
    1145                 1150                 1155 


<210> 7932
<211> 253
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7932
Xaa Val Gly Val Glu Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys 
1               5                   10                  15      


Lys Ser Glu Leu Lys Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg 
            20                  25                  30          


Leu Arg Thr Glu Ile Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu 
        35                  40                  45              


Ile Thr Ala Gly Ala Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala 
    50                  55                  60                  


Phe Gly Pro Asp Gly Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser 
65                  70                  75                  80  


Ala Cys Phe Thr Leu Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly 
                85                  90                  95      


Ile Gly Gly Gly Lys Val Ile Gly Thr Leu Glu Glu Val His Met Pro 
            100                 105                 110         


Gln Asn Gly Ile Asn His Pro Gly Ile Thr Ala Leu Ala Gln Ala Phe 
        115                 120                 125             


Ala Val Asn Pro Leu Leu Arg Val Ile Asn Leu Asn Asp Asn Thr Phe 
    130                 135                 140                 


Thr Glu Lys Gly Ala Val Ala Met Ala Glu Thr Leu Lys Thr Leu Arg 
145                 150                 155                 160 


Gln Val Glu Val Ile Asn Phe Gly Asp Cys Leu Val Arg Ser Lys Gly 
                165                 170                 175     


Ala Val Ala Ile Ala Asp Ala Ile Arg Gly Gly Leu Pro Lys Leu Lys 
            180                 185                 190         


Glu Leu Asn Leu Ser Phe Cys Glu Ile Lys Arg Asp Ala Ala Leu Ala 
        195                 200                 205             


Val Ala Glu Ala Met Ala Asp Lys Ala Glu Leu Glu Lys Leu Asp Leu 
    210                 215                 220                 


Asn Gly Asn Thr Leu Gly Glu Glu Gly Cys Glu Gln Leu Gln Glu Val 
225                 230                 235                 240 


Leu Glu Gly Phe Asn Met Ala Lys Val Leu Ala Ser Leu 
                245                 250             


<210> 7933
<211> 1244
<212> PRT
<213> Homo sapiens

<400> 7933
Asp Val Gly Gly Asp Arg Pro Trp Asp Ser Gly Asn Thr Gln Leu Pro 
1               5                   10                  15      


Pro Arg Asn Pro Val Lys Ala Asn Ala Met Phe Gly Ala Gly Asp Glu 
            20                  25                  30          


Asp Asp Thr Asp Phe Leu Ser Pro Ser Gly Gly Ala Arg Leu Ala Ser 
        35                  40                  45              


Leu Phe Gly Leu Asp Gln Ala Ala Ala Gly His Gly Asn Glu Phe Phe 
    50                  55                  60                  


Gln Tyr Thr Ala Pro Lys Gln Pro Lys Lys Gly Gln Gly Thr Ala Ala 
65                  70                  75                  80  


Thr Gly Asn Gln Ala Thr Pro Lys Thr Ala Pro Ala Thr Met Ser Thr 
                85                  90                  95      


Pro Thr Ile Leu Val Ala Thr Ala Val His Ala Tyr Arg Tyr Thr Asn 
            100                 105                 110         


Gly Gln Tyr Val Lys Gln Gly Lys Phe Gly Ala Ala Val Leu Gly Asn 
        115                 120                 125             


His Thr Ala Arg Glu Tyr Arg Ile Leu Leu Tyr Ile Ser Gln Gln Gln 
    130                 135                 140                 


Pro Val Thr Val Ala Arg Ile His Val Asn Phe Glu Leu Met Val Arg 
145                 150                 155                 160 


Pro Asn Asn Tyr Ser Thr Phe Tyr Asp Asp Gln Arg Gln Asn Trp Ser 
                165                 170                 175     


Ile Met Phe Glu Ser Glu Lys Ala Ala Val Glu Phe Asn Lys Gln Val 
            180                 185                 190         


Cys Ile Ala Lys Cys Asn Ser Thr Ser Ser Leu Asp Ala Val Leu Ser 
        195                 200                 205             


Gln Asp Leu Ile Val Ala Asp Gly Pro Ala Val Glu Val Gly Asp Ser 
    210                 215                 220                 


Leu Glu Val Ala Tyr Thr Gly Trp Leu Phe Gln Asn His Val Leu Gly 
225                 230                 235                 240 


Gln Val Phe Asp Ser Thr Ala Asn Lys Asp Lys Leu Leu Arg Leu Lys 
                245                 250                 255     


Leu Gly Ser Gly Lys Val Ile Lys Gly Trp Glu Asp Gly Met Leu Gly 
            260                 265                 270         


Met Lys Lys Gly Gly Lys Arg Leu Leu Ile Val Pro Pro Ala Cys Ala 
        275                 280                 285             


Val Gly Ser Glu Gly Val Ile Gly Trp Thr Gln Ala Thr Asp Ser Ile 
    290                 295                 300                 


Leu Val Phe Glu Val Glu Val Arg Arg Val Lys Phe Ala Arg Asp Ser 
305                 310                 315                 320 


Gly Ser Asp Gly His Ser Val Ser Ser Arg Asp Ser Ala Ala Pro Ser 
                325                 330                 335     


Pro Ile Pro Gly Ala Asp Asn Leu Ser Ala Asp Pro Val Val Ser Pro 
            340                 345                 350         


Pro Thr Ser Ile Pro Phe Lys Ser Gly Glu Pro Ala Leu Arg Thr Lys 
        355                 360                 365             


Ser Asn Ser Leu Ser Glu Gln Leu Ala Ile Asn Thr Ser Pro Asp Ala 
    370                 375                 380                 


Val Lys Ala Lys Leu Ile Ser Arg Met Ala Lys Met Gly Gln Pro Met 
385                 390                 395                 400 


Leu Pro Ile Leu Pro Pro Gln Leu Asp Ser Asn Asp Ser Glu Ile Glu 
                405                 410                 415     


Asp Val Asn Thr Leu Gln Gly Gly Gly Gln Pro Val Val Thr Pro Ser 
            420                 425                 430         


Val Gln Pro Ser Leu His Pro Ala His Pro Ala Leu Pro Gln Met Thr 
        435                 440                 445             


Ser Gln Ala Pro Gln Pro Ser Val Thr Gly Leu Gln Ala Pro Ser Ala 
    450                 455                 460                 


Ala Leu Met Gln Val Ser Ser Leu Asp Ser His Ser Ala Val Ser Gly 
465                 470                 475                 480 


Asn Ala Gln Ser Phe Gln Pro Tyr Ala Gly Met Gln Ala Tyr Ala Tyr 
                485                 490                 495     


Pro Gln Ala Ser Ala Val Thr Ser Gln Leu Gln Pro Val Arg Pro Leu 
            500                 505                 510         


Tyr Pro Ala Pro Leu Ser Gln Pro Pro His Phe Gln Gly Ser Gly Asp 
        515                 520                 525             


Met Ala Ser Phe Leu Met Thr Glu Ala Arg Gln His Asn Thr Glu Ile 
    530                 535                 540                 


Arg Met Ala Val Ser Lys Val Ala Asp Lys Met Asp His Leu Met Thr 
545                 550                 555                 560 


Lys Val Glu Glu Leu Gln Lys His Ser Ala Gly Asn Ser Met Leu Ile 
                565                 570                 575     


Pro Ser Met Ser Val Thr Met Glu Thr Ser Met Ile Met Ser Asn Ile 
            580                 585                 590         


Gln Arg Ile Ile Gln Glu Asn Glu Arg Leu Lys Gln Glu Ile Leu Glu 
        595                 600                 605             


Lys Ser Asn Arg Ile Glu Glu Gln Asn Asp Lys Ile Ser Glu Leu Ile 
    610                 615                 620                 


Glu Arg Asn Gln Arg Tyr Val Glu Gln Ser Asn Leu Met Met Glu Lys 
625                 630                 635                 640 


Arg Asn Asn Ser Leu Gln Thr Ala Thr Glu Asn Thr Gln Ala Arg Val 
                645                 650                 655     


Leu His Ala Glu Gln Glu Lys Ala Lys Val Thr Glu Glu Leu Ala Ala 
            660                 665                 670         


Ala Thr Ala Gln Val Ser His Leu Gln Leu Lys Met Thr Ala His Gln 
        675                 680                 685             


Lys Lys Glu Thr Glu Leu Gln Met Gln Leu Thr Glu Ser Leu Lys Glu 
    690                 695                 700                 


Thr Asp Leu Leu Arg Gly Gln Leu Thr Lys Val Gln Ala Lys Leu Ser 
705                 710                 715                 720 


Glu Leu Gln Glu Thr Ser Glu Gln Ala Gln Ser Lys Phe Lys Ser Glu 
                725                 730                 735     


Lys Gln Asn Arg Lys Gln Leu Glu Leu Lys Val Thr Ser Leu Glu Glu 
            740                 745                 750         


Glu Leu Thr Asp Leu Arg Val Glu Lys Glu Ser Leu Glu Lys Asn Leu 
        755                 760                 765             


Ser Glu Arg Lys Lys Lys Ser Ala Gln Glu Arg Ser Gln Ala Glu Glu 
    770                 775                 780                 


Glu Ile Asp Glu Ile Arg Lys Ser Tyr Gln Glu Glu Leu Asp Lys Leu 
785                 790                 795                 800 


Arg Gln Leu Leu Lys Lys Thr Arg Val Ser Thr Asp Gln Ala Ala Ala 
                805                 810                 815     


Glu Gln Leu Ser Leu Val Gln Ala Glu Leu Gln Thr Gln Trp Glu Ala 
            820                 825                 830         


Lys Cys Glu His Leu Leu Ala Ser Ala Lys Asp Glu His Leu Gln Gln 
        835                 840                 845             


Tyr Gln Glu Val Cys Ala Gln Arg Asp Ala Tyr Gln Gln Lys Leu Val 
    850                 855                 860                 


Gln Leu Gln Glu Lys Cys Leu Ala Leu Gln Ala Gln Ile Thr Ala Leu 
865                 870                 875                 880 


Thr Lys Gln Asn Glu Gln His Ile Lys Glu Leu Glu Lys Asn Lys Ser 
                885                 890                 895     


Gln Met Ser Gly Val Glu Ala Ala Ala Ser Asp Pro Ser Glu Lys Val 
            900                 905                 910         


Lys Lys Ile Met Asn Gln Val Phe Gln Ser Leu Arg Arg Glu Phe Glu 
        915                 920                 925             


Leu Glu Glu Ser Tyr Asn Gly Arg Thr Ile Leu Gly Thr Ile Met Asn 
    930                 935                 940                 


Thr Ile Lys Met Val Thr Leu Gln Leu Leu Asn Gln Gln Glu Gln Glu 
945                 950                 955                 960 


Lys Glu Glu Ser Ser Ser Glu Glu Glu Glu Glu Lys Ala Glu Glu Arg 
                965                 970                 975     


Pro Arg Arg Pro Ser Gln Glu Gln Ser Ala Ser Ala Ser Ser Gly Gln 
            980                 985                 990         


Pro Gln Ala Pro Leu Asn Arg Glu  Arg Pro Glu Ser Pro  Met Val Pro 
        995                 1000                 1005             


Ser Glu  Gln Val Val Glu Glu  Ala Val Pro Leu Pro  Pro Gln Ala 
    1010                 1015                 1020             


Leu Thr  Thr Ser Gln Asp Gly  His Arg Arg Lys Gly  Asp Ser Glu 
    1025                 1030                 1035             


Ala Glu  Ala Leu Ser Glu Ile  Lys Asp Gly Ser Leu  Pro Pro Glu 
    1040                 1045                 1050             


Leu Ser  Cys Ile Pro Ser His  Arg Val Leu Gly Pro  Pro Thr Ser 
    1055                 1060                 1065             


Ile Pro  Pro Glu Pro Leu Gly  Pro Val Ser Met Asp  Ser Glu Cys 
    1070                 1075                 1080             


Glu Glu  Ser Leu Ala Ala Ser  Pro Met Ala Ala Lys  Pro Asp Asn 
    1085                 1090                 1095             


Pro Ser  Gly Lys Val Cys Val  Arg Glu Val Ala Pro  Asp Gly Pro 
    1100                 1105                 1110             


Leu Gln  Glu Ser Ser Thr Arg  Leu Ser Leu Thr Ser  Asp Pro Glu 
    1115                 1120                 1125             


Glu Gly  Asp Pro Leu Ala Leu  Gly Pro Glu Ser Pro  Gly Glu Pro 
    1130                 1135                 1140             


Gln Pro  Pro Gln Leu Lys Lys  Asp Asp Val Thr Ser  Ser Thr Gly 
    1145                 1150                 1155             


Pro His  Lys Glu Leu Ser Ser  Thr Glu Ala Gly Ser  Thr Val Ala 
    1160                 1165                 1170             


Gly Ala  Ala Leu Arg Pro Ser  His His Ser Gln Arg  Ser Ser Leu 
    1175                 1180                 1185             


Ser Gly  Asp Glu Glu Asp Glu  Leu Phe Lys Gly Ala  Thr Leu Lys 
    1190                 1195                 1200             


Ala Leu  Arg Pro Lys Ala Gln  Pro Glu Glu Glu Asp  Glu Asp Glu 
    1205                 1210                 1215             


Val Ser  Met Lys Gly Arg Pro  Pro Pro Thr Pro Leu  Phe Gly Asp 
    1220                 1225                 1230             


Asp Asp  Asp Asp Asp Asp Ile  Asp Trp Leu Gly 
    1235                 1240                 


<210> 7934
<211> 550
<212> PRT
<213> Homo sapiens

<400> 7934
Met Lys Trp Glu Glu Tyr Glu Glu Leu Leu His Tyr Ala Ile Val Thr 
1               5                   10                  15      


Pro Asn Ile Glu Pro Cys Ala Ser Gln Ser Ser His Pro Lys Gly Glu 
            20                  25                  30          


Leu Val Pro Asp Val Arg Ile Ser Thr Ile His Asp Ile Leu His Ser 
        35                  40                  45              


Gln Gly Asn Asn Ser Glu Val Arg Glu Thr Ala Ile Glu Val Gly Lys 
    50                  55                  60                  


Gly Cys Asp Phe His Ile Ser Ser His Ser Lys Thr Asp Glu Ser Ser 
65                  70                  75                  80  


Pro Val Leu Ser Pro Arg Lys Pro Ser His Pro Val Met Asp Phe Phe 
                85                  90                  95      


Ser Ser His Leu Leu Ala Asp Ser Ser Ser Pro Ala Thr Asn Ser Ser 
            100                 105                 110         


His Thr Asp Ala His Glu Ile Leu Val Ser Asp Phe Leu Val Ser Asp 
        115                 120                 125             


Glu Asn Leu Gln Lys Met Glu Asn Val Leu Asp Leu Trp Ser Ser Gly 
    130                 135                 140                 


Leu Lys Thr Asn Ile Ile Ser Glu Leu Ser Lys Trp Arg Leu Asn Phe 
145                 150                 155                 160 


Ile Asp Trp His Arg Met Glu Met Arg Lys Glu Lys Glu Lys His Ala 
                165                 170                 175     


Ala His Leu Lys Gln Leu Cys Asn Gln Ile Asn Glu Leu Lys Glu Leu 
            180                 185                 190         


Gln Lys Thr Phe Glu Ile Ser Ile Gly Arg Lys Asp Glu Val Ile Ser 
        195                 200                 205             


Ser Leu Ser His Ala Ile Gly Lys Gln Lys Glu Lys Ile Glu Leu Met 
    210                 215                 220                 


Arg Thr Phe Phe His Trp Arg Ile Gly His Val Arg Ala Arg Gln Asp 
225                 230                 235                 240 


Val Tyr Glu Gly Lys Leu Ala Asp Gln Tyr Tyr Gln Arg Thr Leu Leu 
                245                 250                 255     


Lys Lys Val Trp Lys Val Trp Arg Ser Val Val Gln Lys Gln Trp Lys 
            260                 265                 270         


Asp Val Val Glu Arg Ala Cys Gln Ala Arg Ala Glu Glu Val Cys Ile 
        275                 280                 285             


Gln Ile Ser Asn Asp Tyr Glu Ala Lys Val Ala Met Leu Ser Gly Ala 
    290                 295                 300                 


Leu Glu Asn Ala Lys Ala Glu Ile Gln Arg Met Gln His Glu Lys Glu 
305                 310                 315                 320 


His Phe Glu Asp Ser Met Lys Lys Ala Phe Met Arg Gly Val Cys Ala 
                325                 330                 335     


Leu Asn Leu Glu Ala Met Thr Ile Phe Gln Asn Arg Asn Asp Ala Gly 
            340                 345                 350         


Ile Asp Ser Thr Asn Asn Lys Lys Glu Glu Tyr Gly Pro Gly Val Gln 
        355                 360                 365             


Gly Lys Glu His Ser Ala His Leu Asp Pro Ser Ala Pro Pro Met Pro 
    370                 375                 380                 


Leu Pro Val Thr Ser Pro Leu Leu Pro Ser Pro Pro Ala Ala Val Gly 
385                 390                 395                 400 


Gly Ala Ser Ala Thr Ala Val Pro Ser Ala Ala Ser Met Thr Ser Thr 
                405                 410                 415     


Arg Ala Ala Ser Ala Ser Ser Val His Val Pro Val Ser Ala Leu Gly 
            420                 425                 430         


Ala Gly Ser Ala Ala Thr Ala Ala Ser Glu Glu Met Tyr Val Pro Arg 
        435                 440                 445             


Val Val Thr Ser Ala Gln Gln Lys Ala Gly Arg Thr Ile Thr Ala Arg 
    450                 455                 460                 


Ile Thr Gly Arg Cys Asp Phe Ala Ser Lys Asn Arg Ile Ser Ser Ser 
465                 470                 475                 480 


Leu Ala Ile Met Gly Val Ser Pro Pro Met Ser Ser Val Val Val Glu 
                485                 490                 495     


Lys His His Pro Val Thr Val Gln Thr Ile Pro Gln Ala Thr Ala Ala 
            500                 505                 510         


Lys Tyr Pro Arg Thr Ile His Pro Glu Ser Ser Thr Ser Ala Ser Arg 
        515                 520                 525             


Ser Leu Gly Thr Arg Ser Ala His Thr Gln Ser Leu Thr Ser Val His 
    530                 535                 540                 


Ser Ile Lys Val Val Asp 
545                 550 


<210> 7935
<211> 133
<212> PRT
<213> Homo sapiens

<400> 7935
Met Ser Pro Ser Gln Met Ile Met Pro Asn Val Met Glu Met Ile Ala 
1               5                   10                  15      


Ala Leu Gly Pro Gly Pro Ser Pro Tyr Pro Leu Pro Pro Pro Pro Gly 
            20                  25                  30          


Gly Thr Asn Ser Asn Asp Tyr Ser Ser Gln Gly Asn Asn Tyr Gln Gly 
        35                  40                  45              


His Gly Asn Phe Asp Phe Pro His Gly Asn Pro Gly Gly Thr Ser Met 
    50                  55                  60                  


Asn Asp Phe Met His Gly Pro Pro Gln Leu Ser His Pro Pro Asp Met 
65                  70                  75                  80  


Pro Asn Asn Met Ala Ala Leu Glu Lys Pro Leu Ser His Pro Met Gln 
                85                  90                  95      


Glu Thr Leu Leu Pro Glu Leu Thr Asn Pro Asp Glu Leu Leu Ser Tyr 
            100                 105                 110         


Leu Asp Pro Pro Asp Leu Pro Ser Asn Ser Asn Asp Asp Leu Leu Ser 
        115                 120                 125             


Leu Phe Glu Asn Asn 
    130             


<210> 7936
<211> 490
<212> PRT
<213> Homo sapiens

<400> 7936
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Ile Leu Val Lys Thr Met Ile 
        435                 440                 445             


Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu 
    450                 455                 460                 


Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg 
465                 470                 475                 480 


Glu Cys Glu Ser Leu Ser Glu Leu Lys Thr 
                485                 490 


<210> 7937
<211> 623
<212> PRT
<213> Homo sapiens

<400> 7937
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe 
                85                  90                  95      


Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile 
            100                 105                 110         


Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu 
        115                 120                 125             


Asn Lys Phe Leu Leu Leu Thr Phe Ala Ile Glu Ala Leu Glu Cys Ala 
    130                 135                 140                 


Tyr Asp Asn Leu Cys Gln Thr Glu Gly Val Thr Ala Leu Pro Tyr Phe 
145                 150                 155                 160 


Leu Ile Lys Tyr Asp Glu Asn Met Val Leu Val Ser Leu Leu Lys His 
                165                 170                 175     


Tyr Ser Asp Phe Phe Gln Gly Gln Arg Thr Lys Ile Thr Ile Gly Val 
            180                 185                 190         


Tyr Asp Pro Cys Asn Leu Ala Gln Tyr Pro Gly Trp Pro Leu Arg Asn 
        195                 200                 205             


Phe Leu Val Leu Ala Ala His Arg Trp Ser Ser Ser Phe Gln Ser Val 
    210                 215                 220                 


Glu Val Val Cys Phe Arg Asp Arg Thr Met Gln Gly Ala Arg Asp Val 
225                 230                 235                 240 


Ala His Ser Ile Ile Phe Glu Val Lys Leu Pro Glu Met Ala Phe Ser 
                245                 250                 255     


Pro Asp Cys Pro Lys Ala Val Gly Trp Glu Lys Asn Gln Lys Gly Gly 
            260                 265                 270         


Met Gly Pro Arg Met Val Asn Leu Ser Glu Cys Met Asp Pro Lys Arg 
        275                 280                 285             


Leu Ala Glu Ser Ser Val Asp Leu Asn Leu Lys Leu Met Cys Trp Arg 
    290                 295                 300                 


Leu Val Pro Thr Leu Asp Leu Asp Lys Val Val Ser Val Lys Cys Leu 
305                 310                 315                 320 


Leu Leu Gly Ala Gly Thr Leu Gly Cys Asn Val Ala Arg Thr Leu Met 
                325                 330                 335     


Gly Trp Gly Val Arg His Ile Thr Phe Val Asp Asn Ala Lys Ile Ser 
            340                 345                 350         


Tyr Ser Asn Pro Val Arg Gln Pro Leu Tyr Glu Phe Glu Asp Cys Leu 
        355                 360                 365             


Gly Gly Gly Lys Pro Lys Ala Leu Ala Ala Ala Asp Arg Leu Gln Lys 
    370                 375                 380                 


Ile Phe Pro Gly Val Asn Ala Arg Gly Phe Asn Met Ser Ile Pro Met 
385                 390                 395                 400 


Pro Gly His Pro Val Asn Phe Ser Ser Val Thr Leu Glu Gln Ala Arg 
                405                 410                 415     


Arg Asp Val Glu Gln Leu Glu Gln Leu Ile Glu Ser His Asp Val Val 
            420                 425                 430         


Phe Leu Leu Met Asp Thr Arg Glu Ser Arg Trp Leu Pro Ala Val Ile 
        435                 440                 445             


Ala Ala Ser Lys Arg Lys Leu Val Ile Asn Ala Ala Leu Gly Phe Asp 
    450                 455                 460                 


Thr Phe Val Val Met Arg His Gly Leu Lys Lys Pro Lys Gln Gln Gly 
465                 470                 475                 480 


Ala Gly Asp Leu Cys Pro Asn His Pro Val Ala Ser Ala Asp Leu Leu 
                485                 490                 495     


Gly Ser Ser Leu Phe Ala Asn Ile Pro Gly Tyr Lys Leu Gly Cys Tyr 
            500                 505                 510         


Phe Cys Asn Asp Val Val Ala Pro Gly Asp Ser Thr Arg Asp Arg Thr 
        515                 520                 525             


Leu Asp Gln Gln Cys Thr Val Ser Arg Pro Gly Leu Ala Val Ile Ala 
    530                 535                 540                 


Gly Ala Leu Ala Val Glu Leu Met Val Ser Val Leu Gln His Pro Glu 
545                 550                 555                 560 


Gly Gly Tyr Ala Ile Ala Ser Ser Ser Asp Asp Arg Met Asn Glu Pro 
                565                 570                 575     


Pro Thr Ser Leu Gly Leu Val Pro His Gln Ile Arg Gly Phe Leu Ser 
            580                 585                 590         


Arg Phe Asp Asn Val Leu Pro Val Ser Leu Ala Phe Asp Lys Cys Thr 
        595                 600                 605             


Ala Cys Ser Ser Lys Ile Trp Asp Met Ser Asp Asp Glu Thr Ile 
    610                 615                 620             


<210> 7938
<211> 321
<212> PRT
<213> Homo sapiens

<400> 7938
Arg Arg Asn Val Glu Leu Ile Asn Glu Glu Ala Ala Met Phe Asp Ser 
1               5                   10                  15      


Leu Leu Met Asp Ser Tyr Val Ser Ser Thr Thr Gly Glu Ser Val Ile 
            20                  25                  30          


Thr Arg Glu Met Val Glu Met Leu Phe Ser Asp Asp Ser Asp Leu Gln 
        35                  40                  45              


Leu Ala Thr Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys Glu Pro Ser 
    50                  55                  60                  


Pro Pro Ile Asp Glu Val Ile Asn Thr Pro Arg Val Val Asp Arg Phe 
65                  70                  75                  80  


Val Glu Phe Leu Lys Arg Asn Glu Asn Cys Thr Leu Gln Ala Val Trp 
                85                  90                  95      


Ala Leu Gly Asn Ile Ala Gly Asp Ser Ser Val Cys Arg Asp Tyr Val 
            100                 105                 110         


Leu Asn Cys Ser Ile Leu Asn Pro Leu Leu Thr Leu Leu Thr Lys Ser 
        115                 120                 125             


Thr Arg Leu Thr Met Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu 
    130                 135                 140                 


Cys Arg Gly Lys Asn Pro Pro Pro Glu Phe Ala Lys Val Ser Pro Cys 
145                 150                 155                 160 


Leu Pro Val Leu Ser Arg Leu Leu Phe Ser Ser Asp Ser Asp Leu Leu 
                165                 170                 175     


Ala Asp Ala Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Glu 
            180                 185                 190         


Lys Ile Gln Ala Val Ile Asp Ser Gly Val Cys Arg Arg Leu Val Glu 
        195                 200                 205             


Leu Leu Met His Asn Asp Tyr Lys Val Ala Ser Pro Ala Leu Arg Ala 
    210                 215                 220                 


Val Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu 
225                 230                 235                 240 


Asn Cys Ser Ala Leu Pro Cys Leu Leu His Leu Leu Ser Ser Pro Lys 
                245                 250                 255     


Glu Ser Ile Arg Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala 
            260                 265                 270         


Gly Asn Arg Ala Gln Ile Gln Ala Val Ile Asp Ala Asn Ile Phe Pro 
        275                 280                 285             


Val Leu Ile Glu Ile Leu Gln Lys Ala Glu Phe Arg Thr Arg Lys Glu 
    290                 295                 300                 


Ala Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Thr Pro Glu Gln 
305                 310                 315                 320 


Ile 
    


<210> 7939
<211> 264
<212> PRT
<213> Homo sapiens

<400> 7939
Met Gly Gly Ala Gln Leu Glu Leu Pro Ser Gly Ala Arg Pro Gly Val 
1               5                   10                  15      


Cys Val Arg Arg Ser Phe Arg Ala His Ala Gly Asp Gln Pro Arg Arg 
            20                  25                  30          


Pro Pro Gly Pro Ile Pro Val Pro Gly Thr Met Lys Gln Glu Ser Ala 
        35                  40                  45              


Ala Pro Asn Thr Pro Pro Thr Ser Gln Ser Pro Thr Pro Ser Ala Gln 
    50                  55                  60                  


Phe Pro Arg Asn Asp Gly Asp Pro Gln Ala Leu Trp Ile Phe Gly Tyr 
65                  70                  75                  80  


Gly Ser Leu Val Trp Arg Pro Asp Phe Ala Tyr Ser Asp Ser Arg Val 
                85                  90                  95      


Gly Phe Val Arg Gly Tyr Ser Arg Arg Phe Trp Gln Gly Asp Thr Phe 
            100                 105                 110         


His Arg Gly Ser Asp Lys Met Pro Gly Arg Val Val Thr Leu Leu Glu 
        115                 120                 125             


Asp His Glu Gly Cys Thr Trp Gly Val Ala Tyr Gln Val Gln Gly Glu 
    130                 135                 140                 


Gln Val Ser Lys Ala Leu Lys Tyr Leu Asn Val Arg Glu Ala Val Leu 
145                 150                 155                 160 


Gly Gly Tyr Asp Thr Lys Glu Val Thr Phe Tyr Pro Gln Asp Ala Pro 
                165                 170                 175     


Asp Gln Pro Leu Lys Ala Leu Ala Tyr Val Ala Thr Pro Gln Asn Pro 
            180                 185                 190         


Gly Tyr Leu Gly Pro Ala Pro Glu Glu Ala Ile Ala Thr Gln Ile Leu 
        195                 200                 205             


Ala Cys Arg Gly Phe Ser Gly His Asn Leu Glu Tyr Leu Leu Arg Leu 
    210                 215                 220                 


Ala Asp Phe Met Gln Leu Cys Gly Pro Gln Ala Gln Asp Glu His Leu 
225                 230                 235                 240 


Ala Ala Ile Val Asp Ala Val Gly Thr Met Leu Pro Cys Phe Cys Pro 
                245                 250                 255     


Thr Glu Gln Ala Leu Ala Leu Val 
            260                 


<210> 7940
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7940
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 7941
<211> 255
<212> PRT
<213> Homo sapiens

<400> 7941
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Thr Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Thr His Gly Thr Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Thr Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu Asp Tyr Asn Asn Asp Thr Pro Leu Ser Trp Ala Ala Met Lys 
        115                 120                 125             


Gly Asn Leu Glu Ser Val Ser Ile Leu Leu Asp Tyr Gly Ala Glu Val 
    130                 135                 140                 


Arg Val Ile Asn Leu Ile Gly Gln Thr Pro Ile Ser Arg Leu Val Ala 
145                 150                 155                 160 


Leu Leu Val Arg Gly Leu Gly Thr Glu Lys Glu Asp Ser Cys Phe Glu 
                165                 170                 175     


Leu Leu His Arg Ala Val Gly His Phe Glu Leu Arg Lys Asn Gly Thr 
            180                 185                 190         


Met Pro Arg Glu Val Ala Arg Asp Pro Gln Leu Cys Glu Lys Leu Thr 
        195                 200                 205             


Val Leu Cys Ser Ala Pro Gly Thr Leu Lys Thr Leu Ala Arg Tyr Ala 
    210                 215                 220                 


Val Arg Arg Ser Leu Gly Leu Gln Tyr Leu Pro Asp Ala Val Lys Gly 
225                 230                 235                 240 


Leu Pro Leu Pro Ala Ser Leu Lys Glu Tyr Leu Leu Leu Leu Glu 
                245                 250                 255 


<210> 7942
<211> 194
<212> PRT
<213> Homo sapiens

<400> 7942
Glu Pro Val Gln Pro His Trp Phe Tyr Cys Lys Glu Val Glu Tyr Lys 
1               5                   10                  15      


Gln Leu Trp Met Pro Phe Ser Val Phe Asp Ser Leu Asn Leu Glu Glu 
            20                  25                  30          


Ile Tyr Asn Ser Val Gln Pro Asp Pro Glu Ser Val Val Leu Gly Thr 
        35                  40                  45              


Asp Gly Gly Arg Tyr Asp Val Tyr Leu Tyr Asp Arg Ile Arg Lys Ala 
    50                  55                  60                  


Ala Tyr Trp Glu Glu Glu Pro Ala Glu Val Arg Arg Cys Thr Trp Phe 
65                  70                  75                  80  


Tyr Lys Gly Asp Thr Asp Ser Arg Phe Ile Pro Tyr Thr Glu Glu Phe 
                85                  90                  95      


Ser Glu Lys Leu Glu Val Ile Val Gln Phe Gln Pro Ser Ser Val Pro 
            100                 105                 110         


Asp Glu Trp Gly Thr Thr Gln Asp Gly Gln Thr Arg Pro Arg Val Val 
        115                 120                 125             


Lys Arg Gly Ile Asp Asp Asn Leu Asp Glu Ile Pro Asp Gly Glu Met 
    130                 135                 140                 


Pro Gln Val Asp His Leu Val Phe Val Val His Gly Ile Gly Pro Val 
145                 150                 155                 160 


Cys Asp Leu Arg Phe Arg Ser Ile Ile Glu Cys Val Asp Asp Phe Arg 
                165                 170                 175     


Val Val Ser Leu Lys Leu Leu Arg Thr His Phe Lys Lys Ser Leu Asp 
            180                 185                 190         


Asp Gly 
        


<210> 7943
<211> 326
<212> PRT
<213> Homo sapiens

<400> 7943
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 
                245                 250                 255     


Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 
            260                 265                 270         


Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 
        275                 280                 285             


Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 
    290                 295                 300                 


Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 
305                 310                 315                 320 


Ala Phe Pro Val Asp Gly 
                325     


<210> 7944
<211> 329
<212> PRT
<213> Homo sapiens

<400> 7944
Met Ala Gly Ala Leu Glu Gly Asp Ile Phe Ile Gly Pro Lys Ala Glu 
1               5                   10                  15      


Glu His Arg Gly Leu Leu Ser Ile Arg Tyr Pro Met Glu His Gly Ile 
            20                  25                  30          


Val Lys Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser 
        35                  40                  45              


Lys Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr 
    50                  55                  60                  


Glu Ala Pro Leu Asn Pro Arg Lys Asn Arg Glu Arg Ala Ala Glu Val 
65                  70                  75                  80  


Phe Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala 
                85                  90                  95      


Val Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp 
            100                 105                 110         


Ser Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala 
        115                 120                 125             


Met Pro His Ser Ile Met Arg Ile Asp Ile Ala Gly Arg Asp Val Ser 
    130                 135                 140                 


Arg Phe Leu Arg Leu Tyr Leu Arg Lys Glu Gly Tyr Asp Phe His Ser 
145                 150                 155                 160 


Ser Ser Glu Phe Glu Ile Val Lys Ala Ile Lys Glu Arg Ala Cys Tyr 
                165                 170                 175     


Leu Ser Ile Asn Pro Gln Lys Asp Glu Thr Leu Glu Thr Glu Lys Ala 
            180                 185                 190         


Gln Tyr Tyr Leu Pro Asp Gly Ser Thr Ile Glu Ile Gly Pro Ser Arg 
        195                 200                 205             


Phe Arg Ala Pro Glu Leu Leu Phe Arg Pro Asp Leu Ile Gly Glu Glu 
    210                 215                 220                 


Ser Glu Gly Ile His Glu Val Leu Val Phe Ala Ile Gln Lys Ser Asp 
225                 230                 235                 240 


Met Asp Leu Arg Arg Thr Leu Phe Ser Asn Ile Val Leu Ser Gly Gly 
                245                 250                 255     


Ser Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys 
            260                 265                 270         


Lys Leu Ala Pro Lys Asp Val Lys Ile Arg Ile Ser Ala Pro Gln Glu 
        275                 280                 285             


Arg Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp 
    290                 295                 300                 


Thr Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly 
305                 310                 315                 320 


Ala Arg Ser Ile His Arg Lys Thr Phe 
                325                 


<210> 7945
<211> 149
<212> PRT
<213> Homo sapiens

<400> 7945
Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
65                  70                  75                  80  


Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                85                  90                  95      


Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Asp Asn 
    130                 135                 140                 


Ser Gln Gly Ala Tyr 
145                 


<210> 7946
<211> 244
<212> PRT
<213> Homo sapiens

<400> 7946
Met Leu Ser Asp Arg Lys Arg Glu Leu Glu His Arg Leu Ser Ala Thr 
1               5                   10                  15      


Leu Glu Glu Asn Asp Leu Leu Gln Gly Thr Val Glu Glu Leu Gln Asp 
            20                  25                  30          


Arg Val Leu Ile Leu Glu Arg Gln Gly His Asp Lys Asp Leu Gln Leu 
        35                  40                  45              


His Gln Ser Gln Leu Glu Leu Gln Glu Val Arg Leu Ser Cys Arg Gln 
    50                  55                  60                  


Leu Gln Val Lys Val Glu Glu Leu Thr Glu Glu Arg Ser Leu Gln Ser 
65                  70                  75                  80  


Ser Ala Ala Thr Ser Thr Ser Leu Leu Ser Glu Ile Glu Gln Ser Met 
                85                  90                  95      


Glu Ala Glu Glu Leu Glu Gln Glu Arg Glu Gln Val Thr Leu Leu Ser 
            100                 105                 110         


Val Glu Met Thr Ala Leu Lys Glu Glu Arg Asp Arg Leu Arg Val Thr 
        115                 120                 125             


Ser Glu Asp Lys Glu Pro Lys Glu Gln Leu Gln Lys Ala Ile Arg Asp 
    130                 135                 140                 


Arg Asp Glu Ala Ile Ala Lys Lys Asn Ala Val Glu Leu Glu Leu Ala 
145                 150                 155                 160 


Lys Cys Arg Met Asp Met Met Ser Leu Asn Ser Gln Leu Leu Asp Ala 
                165                 170                 175     


Ile Gln Gln Lys Leu Asn Leu Ser Gln Gln Leu Glu Ala Trp Gln Asp 
            180                 185                 190         


Asp Met His Arg Val Ile Asp Arg Gln Leu Met Asp Thr His Leu Lys 
        195                 200                 205             


Glu Arg Ser Gln Pro Ala Ala Ala Leu Cys Arg Gly His Ser Ala Gly 
    210                 215                 220                 


Arg Gly Asp Glu Pro Ser Ile Ala Glu Gly Lys Arg Leu Phe Ser Phe 
225                 230                 235                 240 


Phe Arg Lys Ile 
                


<210> 7947
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 7947
Xaa His Met Leu Ser Lys Val Gly Met Trp Asp Phe Asp Ile Phe Leu 
1               5                   10                  15      


Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Thr Leu Leu Cys His 
            20                  25                  30          


Leu Phe Asn Thr His Gly Leu Ile His His Phe Lys Leu Asp Met Val 
        35                  40                  45              


Thr Leu His Arg Phe Leu Val Met Val Gln Glu Asp Tyr His Ser Gln 
    50                  55                  60                  


Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala Met 
65                  70                  75                  80  


His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Ser Phe Leu Thr Pro Leu 
                85                  90                  95      


Asp Ile Met Leu Gly Leu Leu Ala Ala Ala Ala His Asp Val Asp His 
            100                 105                 110         


Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His His Leu Ala 
        115                 120                 125             


Asn Leu Tyr Gln Val Arg Glu Pro Asn Leu Glu Pro Ala Thr Val Trp 
    130                 135                 140                 


Ser Ile Ala Leu Gly Pro Val Leu Lys Pro Glu Ser Cys Pro Trp Arg 
145                 150                 155                 160 


Lys Pro Cys Phe Arg Val Leu Glu Val Gln Arg Arg Met Lys His Asn 
                165                 170                 175     


Leu Cys Pro Gln Lys Phe Val Gln Thr Gln Met Leu Lys Met Ser Lys 
            180                 185                 190         


Ile Gln Ala Asn Leu Ile Pro Val 
        195                 200 


<210> 7948
<211> 575
<212> PRT
<213> Homo sapiens

<400> 7948
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 
            100                 105                 110         


Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 
        115                 120                 125             


Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 
    130                 135                 140                 


Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 
145                 150                 155                 160 


Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 
                165                 170                 175     


Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 
            180                 185                 190         


Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 
        195                 200                 205             


Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 
    210                 215                 220                 


Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 
225                 230                 235                 240 


His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 
                245                 250                 255     


Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 
            260                 265                 270         


Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 
        275                 280                 285             


Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 
    290                 295                 300                 


Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 
305                 310                 315                 320 


Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 
                325                 330                 335     


Gly Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn 
            340                 345                 350         


Tyr Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys 
        355                 360                 365             


Met Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser 
    370                 375                 380                 


Lys Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His 
385                 390                 395                 400 


Ala Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys 
                405                 410                 415     


Asp Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys 
            420                 425                 430         


Thr Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met 
        435                 440                 445             


Ser Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser 
    450                 455                 460                 


Ile Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro 
465                 470                 475                 480 


Phe Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala 
                485                 490                 495     


Gln Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg 
            500                 505                 510         


Leu Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr 
        515                 520                 525             


Val Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile 
    530                 535                 540                 


Thr Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala 
545                 550                 555                 560 


Glu Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 
                565                 570                 575 


<210> 7949
<211> 1011
<212> PRT
<213> Homo sapiens

<400> 7949
Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
                565                 570                 575     


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
            580                 585                 590         


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
        595                 600                 605             


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
    610                 615                 620                 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
625                 630                 635                 640 


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
                645                 650                 655     


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
            660                 665                 670         


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
        675                 680                 685             


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
    690                 695                 700                 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
705                 710                 715                 720 


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
                725                 730                 735     


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
            740                 745                 750         


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
        755                 760                 765             


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
    770                 775                 780                 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
785                 790                 795                 800 


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
                805                 810                 815     


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
            820                 825                 830         


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
        835                 840                 845             


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
    850                 855                 860                 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
865                 870                 875                 880 


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
                885                 890                 895     


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
            900                 905                 910         


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
        915                 920                 925             


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
    930                 935                 940                 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
945                 950                 955                 960 


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
                965                 970                 975     


Leu Leu Asn Ser Gln Gln Leu Thr Pro Val His Arg His Pro His Phe 
            980                 985                 990         


Thr Gln Leu Pro Pro Thr His Phe  Ser Pro Ser Met Glu  Ile Met Gln 
        995                 1000                 1005             


Val Arg  Lys 
    1010     


<210> 7950
<211> 1261
<212> PRT
<213> Homo sapiens

<400> 7950
Met Ala Ala Ala Ala Ala Ser Gly Ala Gly Gly Ala Ala Gly Ala Gly 
1               5                   10                  15      


Thr Gly Gly Ala Gly Pro Ala Gly Arg Leu Leu Pro Pro Pro Ala Pro 
            20                  25                  30          


Gly Ser Pro Ala Ala Pro Ala Ala Val Ser Pro Ala Ala Gly Gln Pro 
        35                  40                  45              


Arg Pro Pro Ala Pro Ala Ser Arg Gly Pro Met Pro Ala Arg Ile Gly 
    50                  55                  60                  


Tyr Tyr Glu Ile Asp Arg Thr Ile Gly Lys Gly Asn Phe Ala Val Val 
65                  70                  75                  80  


Lys Arg Ala Thr His Leu Val Thr Lys Ala Lys Val Ala Ile Lys Ile 
                85                  90                  95      


Ile Asp Lys Thr Gln Leu Asp Glu Glu Asn Leu Lys Lys Ile Phe Arg 
            100                 105                 110         


Glu Val Gln Ile Met Lys Met Leu Cys His Pro His Ile Ile Arg Leu 
        115                 120                 125             


Tyr Gln Val Met Glu Thr Glu Arg Met Ile Tyr Leu Val Thr Glu Tyr 
    130                 135                 140                 


Ala Ser Gly Gly Glu Ile Phe Asp His Leu Val Ala His Gly Arg Met 
145                 150                 155                 160 


Ala Glu Lys Glu Ala Arg Arg Lys Phe Lys Gln Ile Val Thr Ala Val 
                165                 170                 175     


Tyr Phe Cys His Cys Arg Asn Ile Val His Arg Asp Leu Lys Ala Glu 
            180                 185                 190         


Asn Leu Leu Leu Asp Ala Asn Leu Asn Ile Lys Ile Ala Asp Phe Gly 
        195                 200                 205             


Phe Ser Asn Leu Phe Thr Pro Gly Gln Leu Leu Lys Thr Trp Cys Gly 
    210                 215                 220                 


Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe Glu Gly Lys Glu Tyr Asp 
225                 230                 235                 240 


Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Val Val Leu Tyr Val Leu 
                245                 250                 255     


Val Cys Gly Ala Leu Pro Phe Asp Gly Ser Thr Leu Gln Asn Leu Arg 
            260                 265                 270         


Ala Arg Val Leu Ser Gly Lys Phe Arg Ile Pro Phe Phe Met Ser Thr 
        275                 280                 285             


Glu Cys Glu His Leu Ile Arg His Met Leu Val Leu Asp Pro Asn Lys 
    290                 295                 300                 


Arg Leu Ser Met Glu Gln Ile Cys Lys His Lys Trp Met Lys Leu Gly 
305                 310                 315                 320 


Asp Ala Asp Pro Asn Phe Asp Arg Leu Ile Ala Glu Cys Gln Gln Leu 
                325                 330                 335     


Lys Glu Glu Arg Gln Val Asp Pro Leu Asn Glu Asp Val Leu Leu Ala 
            340                 345                 350         


Met Glu Asp Met Gly Leu Asp Lys Glu Gln Thr Leu Gln Ala Glu Gln 
        355                 360                 365             


Ala Gly Thr Ala Met Asn Ile Ser Val Pro Gln Val Gln Leu Ile Asn 
    370                 375                 380                 


Pro Glu Asn Gln Ile Val Glu Pro Asp Gly Thr Leu Asn Leu Asp Ser 
385                 390                 395                 400 


Asp Glu Gly Glu Glu Pro Ser Pro Glu Ala Leu Val Arg Tyr Leu Ser 
                405                 410                 415     


Met Arg Arg His Thr Val Gly Val Ala Asp Pro Arg Thr Glu Val Met 
            420                 425                 430         


Glu Asp Leu Gln Lys Leu Leu Pro Gly Phe Pro Gly Val Asn Pro Gln 
        435                 440                 445             


Ala Pro Phe Leu Gln Val Ala Pro Asn Val Asn Phe Met His Asn Leu 
    450                 455                 460                 


Leu Pro Met Gln Asn Leu Gln Pro Thr Gly Gln Leu Glu Tyr Lys Glu 
465                 470                 475                 480 


Gln Ser Leu Leu Gln Pro Pro Thr Leu Gln Leu Leu Asn Gly Met Gly 
                485                 490                 495     


Pro Leu Gly Arg Arg Ala Ser Asp Gly Gly Ala Asn Ile Gln Leu His 
            500                 505                 510         


Ala Gln Gln Leu Leu Lys Arg Pro Arg Gly Pro Ser Pro Leu Val Thr 
        515                 520                 525             


Met Thr Pro Ala Val Pro Ala Val Thr Pro Val Asp Glu Glu Ser Ser 
    530                 535                 540                 


Asp Gly Glu Pro Asp Gln Glu Ala Val Gln Arg Tyr Leu Ala Asn Arg 
545                 550                 555                 560 


Ser Lys Arg His Thr Leu Ala Met Thr Asn Pro Thr Ala Glu Ile Pro 
                565                 570                 575     


Pro Asp Leu Gln Arg Gln Leu Gly Gln Gln Pro Phe Arg Ser Arg Val 
            580                 585                 590         


Trp Pro Pro His Leu Val Pro Asp Gln His Arg Ser Thr Tyr Lys Asp 
        595                 600                 605             


Ser Asn Thr Leu His Leu Pro Thr Glu Arg Phe Ser Pro Val Arg Arg 
    610                 615                 620                 


Phe Ser Asp Gly Ala Ala Ser Ile Gln Ala Phe Lys Ala His Leu Glu 
625                 630                 635                 640 


Lys Met Gly Asn Asn Ser Ser Ile Lys Gln Leu Gln Gln Glu Cys Glu 
                645                 650                 655     


Gln Leu Gln Lys Met Tyr Gly Gly Gln Ile Asp Glu Arg Thr Leu Glu 
            660                 665                 670         


Lys Thr Gln Gln Gln His Met Leu Tyr Gln Gln Glu Gln His His Gln 
        675                 680                 685             


Ile Leu Gln Gln Gln Ile Gln Asp Ser Ile Cys Pro Pro Gln Pro Ser 
    690                 695                 700                 


Pro Pro Leu Gln Ala Ala Cys Glu Asn Gln Pro Ala Leu Leu Thr His 
705                 710                 715                 720 


Gln Leu Gln Arg Leu Arg Ile Gln Pro Ser Ser Pro Pro Pro Asn His 
                725                 730                 735     


Pro Asn Asn His Leu Phe Arg Gln Pro Ser Asn Ser Pro Pro Pro Met 
            740                 745                 750         


Ser Ser Ala Met Ile Gln Pro His Gly Ala Ala Ser Ser Ser Gln Phe 
        755                 760                 765             


Gln Gly Leu Pro Ser Arg Ser Ala Ile Phe Gln Gln Gln Pro Glu Asn 
    770                 775                 780                 


Cys Ser Ser Pro Pro Asn Val Ala Leu Thr Cys Leu Gly Met Gln Gln 
785                 790                 795                 800 


Pro Ala Gln Ser Gln Gln Val Thr Ile Gln Val Gln Glu Pro Val Asp 
                805                 810                 815     


Met Leu Ser Asn Met Pro Gly Thr Ala Ala Gly Ser Ser Gly Arg Gly 
            820                 825                 830         


Ile Ser Ile Ser Pro Ser Ala Gly Gln Met Gln Met Gln His Arg Thr 
        835                 840                 845             


Asn Leu Met Ala Thr Leu Ser Tyr Gly His Arg Pro Leu Ser Lys Gln 
    850                 855                 860                 


Leu Ser Ala Asp Ser Ala Glu Ala His Ser Ala His Gln Gln Pro Pro 
865                 870                 875                 880 


His Tyr Thr Thr Ser Ala Leu Gln Gln Ala Leu Leu Ser Pro Thr Pro 
                885                 890                 895     


Pro Asp Tyr Thr Arg His Gln Gln Val Pro His Ile Leu Gln Gly Leu 
            900                 905                 910         


Leu Ser Pro Arg His Ser Leu Thr Gly His Ser Asp Ile Arg Leu Pro 
        915                 920                 925             


Pro Thr Glu Phe Ala Gln Leu Ile Lys Arg Gln Gln Gln Gln Arg Gln 
    930                 935                 940                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Tyr Gln Glu Leu Phe Arg 
945                 950                 955                 960 


His Met Asn Gln Gly Asp Ala Gly Ser Leu Ala Pro Ser Leu Gly Gly 
                965                 970                 975     


Gln Ser Met Thr Glu Arg Gln Ala Leu Ser Tyr Gln Asn Ala Asp Ser 
            980                 985                 990         


Tyr His His His Thr Ser Pro Gln  His Leu Leu Gln Ile  Arg Ala Gln 
        995                 1000                 1005             


Glu Cys  Val Ser Gln Ala Ser  Ser Pro Thr Pro Pro  His Gly Tyr 
    1010                 1015                 1020             


Ala His  Gln Pro Ala Leu Met  His Ser Glu Ser Met  Glu Glu Asp 
    1025                 1030                 1035             


Cys Ser  Cys Glu Gly Ala Lys  Asp Gly Phe Gln Asp  Ser Lys Ser 
    1040                 1045                 1050             


Ser Ser  Thr Leu Thr Lys Gly  Cys His Asp Ser Pro  Leu Leu Leu 
    1055                 1060                 1065             


Ser Thr  Gly Gly Pro Gly Asp  Pro Glu Ser Leu Leu  Gly Thr Val 
    1070                 1075                 1080             


Ser His  Ala Gln Glu Leu Gly  Ile His Pro Tyr Gly  His Gln Pro 
    1085                 1090                 1095             


Thr Ala  Ala Phe Ser Lys Asn  Lys Val Pro Ser Arg  Glu Pro Val 
    1100                 1105                 1110             


Ile Gly  Asn Cys Met Asp Arg  Ser Ser Pro Gly Gln  Ala Val Glu 
    1115                 1120                 1125             


Leu Pro  Asp His Asn Gly Leu  Gly Tyr Pro Ala Arg  Pro Ser Val 
    1130                 1135                 1140             


His Glu  His His Arg Pro Arg  Ala Leu Gln Arg His  His Thr Ile 
    1145                 1150                 1155             


Gln Asn  Ser Asp Asp Ala Tyr  Val Gln Leu Asp Asn  Leu Pro Gly 
    1160                 1165                 1170             


Met Ser  Leu Val Ala Gly Lys  Ala Leu Ser Ser Ala  Arg Met Ser 
    1175                 1180                 1185             


Asp Ala  Val Leu Ser Gln Ser  Ser Leu Met Gly Ser  Gln Gln Phe 
    1190                 1195                 1200             


Gln Asp  Gly Glu Asn Glu Glu  Cys Gly Ala Ser Leu  Gly Gly His 
    1205                 1210                 1215             


Glu His  Pro Asp Leu Ser Asp  Gly Ser Gln His Leu  Asn Ser Ser 
    1220                 1225                 1230             


Cys Tyr  Pro Ser Thr Cys Ile  Thr Asp Ile Leu Leu  Ser Tyr Lys 
    1235                 1240                 1245             


His Pro  Glu Val Ser Phe Ser  Met Glu Gln Ala Gly  Val 
    1250                 1255                 1260     


<210> 7951
<211> 172
<212> PRT
<213> Homo sapiens

<400> 7951
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Phe Gln Phe Val Ser Ser Ser Leu Pro Asp Ile Cys Tyr 
        35                  40                  45              


Arg Cys Gly Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln Glu 
    50                  55                  60                  


Asp Val Glu Ala Cys Tyr Asn Cys Gly Arg Gly Gly His Ile Ala Lys 
65                  70                  75                  80  


Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln Cys Cys Tyr Asn Cys 
                85                  90                  95      


Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp His Ala Asp Glu Gln 
            100                 105                 110         


Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile Gln Lys Asp Cys Thr 
        115                 120                 125             


Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly His Val Ala Ile Asn 
    130                 135                 140                 


Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly 
145                 150                 155                 160 


His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr Ala 
                165                 170         


<210> 7952
<211> 156
<212> PRT
<213> Homo sapiens

<400> 7952
Met Leu Ala Glu Lys Leu Pro Asn Leu Thr His Leu Asn Leu Ser Gly 
1               5                   10                  15      


Asn Lys Leu Lys Asp Ile Ser Thr Leu Glu Pro Leu Lys Lys Leu Glu 
            20                  25                  30          


Cys Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu Asn 
        35                  40                  45              


Asp Tyr Arg Glu Ser Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr Leu 
    50                  55                  60                  


Asp Gly Tyr Asp Arg Glu Asp Gln Glu Ala Pro Asp Ser Asp Ala Glu 
65                  70                  75                  80  


Val Asp Gly Val Asp Glu Glu Glu Glu Asp Glu Glu Gly Glu Asp Glu 
                85                  90                  95      


Glu Asp Glu Asp Asp Glu Asp Gly Glu Glu Glu Glu Phe Asp Glu Glu 
            100                 105                 110         


Asp Asp Glu Asp Glu Asp Val Glu Gly Asp Glu Asp Asp Asp Glu Val 
        115                 120                 125             


Ser Glu Glu Glu Glu Glu Phe Gly Leu Asp Glu Glu Asp Glu Asp Glu 
    130                 135                 140                 


Asp Glu Asp Glu Glu Glu Glu Glu Gly Gly Lys Gly 
145                 150                 155     


<210> 7953
<211> 171
<212> PRT
<213> Homo sapiens

<400> 7953
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu 
                165                 170     


<210> 7954
<211> 36
<212> PRT
<213> Homo sapiens

<400> 7954
Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
1               5                   10                  15      


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
            20                  25                  30          


Val His Glu Val 
        35      


<210> 7955
<211> 212
<212> PRT
<213> Homo sapiens

<400> 7955
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Thr Glu Ser 
    50                  55                  60                  


Arg Gly Thr Asp Thr Glu Ser Ser Gly Glu Asp Lys Asp Ser Asp Ser 
65                  70                  75                  80  


Met Glu Asp Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His 
                85                  90                  95      


Asp Arg Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Gln Pro Arg Arg Arg Val Gln Arg Lys Arg Ala Asn Arg Asp Gln Asp 
        115                 120                 125             


Ser Ser Asp Asp Glu Arg Ala Leu Glu Asp Trp Val Ser Ser Glu Thr 
    130                 135                 140                 


Ser Ala Leu Pro Arg Pro Arg Trp Gln Ala Leu Pro Ala Leu Arg Glu 
145                 150                 155                 160 


Arg Glu Leu Gly Ser Ser Ala Arg Phe Val Tyr Glu Ala Cys Gly Ala 
                165                 170                 175     


Arg Val Phe Val Gln Arg Phe Arg Leu Gln His Gly Leu Glu Gly His 
            180                 185                 190         


Thr Gly Cys Val Asn Thr Leu His Phe Asn Gln Arg Gly Thr Trp Leu 
        195                 200                 205             


Ala Ser Gly Ser 
    210         


<210> 7956
<211> 241
<212> PRT
<213> Homo sapiens

<400> 7956
Met Thr Ser Val Thr Arg Ser Glu Ile Ile Asp Glu Lys Gly Pro Val 
1               5                   10                  15      


Met Ser Lys Thr His Asp His Gln Leu Glu Ser Ser Leu Ser Pro Val 
            20                  25                  30          


Glu Val Phe Ala Lys Thr Ser Ala Ser Leu Glu Met Asn Gln Gly Val 
        35                  40                  45              


Ser Glu Glu Arg Ile His Leu Gly Ser Ser Pro Lys Lys Gly Gly Asn 
    50                  55                  60                  


Cys Asp Leu Ser His Gln Glu Arg Leu Gln Ser Lys Ser Leu His Leu 
65                  70                  75                  80  


Ser Pro Gln Glu Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp 
                85                  90                  95      


Arg Arg Ala Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro 
            100                 105                 110         


Ile His Gln Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu 
        115                 120                 125             


Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe 
    130                 135                 140                 


Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser 
145                 150                 155                 160 


Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys 
                165                 170                 175     


His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe 
            180                 185                 190         


Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val 
        195                 200                 205             


Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr 
    210                 215                 220                 


Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu 
225                 230                 235                 240 


Ser 
    


<210> 7957
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7957
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210> 7958
<211> 628
<212> PRT
<213> Homo sapiens

<400> 7958
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr Asp 
            100                 105                 110         


Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg Leu 
        115                 120                 125             


His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg 
    130                 135                 140                 


Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His 
145                 150                 155                 160 


Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val 
                165                 170                 175     


Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys 
            180                 185                 190         


Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu 
        195                 200                 205             


His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile 
    210                 215                 220                 


Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly 
225                 230                 235                 240 


Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu 
                245                 250                 255     


Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val 
            260                 265                 270         


Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala 
        275                 280                 285             


Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala 
    290                 295                 300                 


Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe 
305                 310                 315                 320 


His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro 
                325                 330                 335     


Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp 
            340                 345                 350         


Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala 
        355                 360                 365             


Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln 
    370                 375                 380                 


Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser 
385                 390                 395                 400 


Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val 
                405                 410                 415     


Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr 
            420                 425                 430         


Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr 
        435                 440                 445             


Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu 
    450                 455                 460                 


Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly 
465                 470                 475                 480 


Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr 
                485                 490                 495     


Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu 
            500                 505                 510         


Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro 
        515                 520                 525             


Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn 
    530                 535                 540                 


Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly 
545                 550                 555                 560 


Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val 
                565                 570                 575     


Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu 
            580                 585                 590         


Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu 
        595                 600                 605             


Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val 
    610                 615                 620                 


Glu Leu Ser Ala 
625             


<210> 7959
<211> 547
<212> PRT
<213> Homo sapiens

<400> 7959
Met Ala Gly Thr Lys Asn Lys Thr Arg Ala Gln Ala Lys Thr Glu Lys 
1               5                   10                  15      


Lys Ala Ala Ile Gln Ala Lys Ala Gly Ala Glu Arg Glu Ala Thr Gly 
            20                  25                  30          


Val Val Arg Pro Val Ala Lys Thr Arg Ala Lys Ala Lys Ala Lys Thr 
        35                  40                  45              


Gly Ser Lys Thr Asp Ala Val Ala Glu Met Lys Ala Val Ser Lys Asn 
    50                  55                  60                  


Lys Val Val Ala Glu Thr Lys Glu Gly Ala Leu Ser Glu Pro Lys Thr 
65                  70                  75                  80  


Leu Gly Lys Ala Met Gly Asp Phe Thr Pro Lys Ala Gly Asn Glu Ser 
                85                  90                  95      


Thr Ser Ser Thr Cys Lys Asn Glu Ala Gly Thr Asp Ala Trp Phe Trp 
            100                 105                 110         


Ala Gly Glu Glu Ala Thr Ile Asn Ser Trp Phe Trp Asn Gly Glu Glu 
        115                 120                 125             


Ala Gly Asn Ser Phe Ser Thr Lys Asn Asp Lys Pro Glu Ile Gly Ala 
    130                 135                 140                 


Gln Val Cys Ala Glu Glu Leu Glu Pro Ala Ala Gly Ala Asp Cys Lys 
145                 150                 155                 160 


Pro Arg Ser Gly Ala Glu Glu Glu Glu Glu Glu Asn Val Ile Gly Asn 
                165                 170                 175     


Trp Phe Trp Glu Gly Asp Asp Thr Ser Phe Asp Pro Asn Pro Lys Pro 
            180                 185                 190         


Val Ser Arg Ile Val Lys Pro Gln Pro Val Tyr Glu Ile Asn Glu Lys 
        195                 200                 205             


Asn Arg Pro Lys Asp Trp Ser Glu Val Thr Ile Trp Pro Asn Ala Pro 
    210                 215                 220                 


Ala Val Thr Pro Ala Val Leu Gly Phe Arg Ser Gln Ala Pro Ser Glu 
225                 230                 235                 240 


Ala Ser Pro Pro Ser Tyr Ile Val Leu Ala Ser Ala Glu Glu Asn Ala 
                245                 250                 255     


Cys Ser Leu Pro Val Ala Thr Ala Cys Arg Pro Ser Arg Asn Thr Arg 
            260                 265                 270         


Ser Cys Ser Gln Pro Ile Pro Glu Cys Arg Phe Asp Ser Asp Pro Cys 
        275                 280                 285             


Ile Gln Thr Ile Asp Glu Ile Arg Arg Gln Ile Arg Ile Arg Glu Val 
    290                 295                 300                 


Asn Gly Ile Lys Pro Phe Ala Cys Pro Cys Lys Met Glu Cys Tyr Met 
305                 310                 315                 320 


Asp Ser Glu Glu Phe Glu Lys Leu Val Ser Leu Leu Lys Ser Thr Thr 
                325                 330                 335     


Asp Pro Leu Ile His Lys Ile Ala Arg Ile Ala Met Gly Val His Asn 
            340                 345                 350         


Val His Pro Phe Ala Gln Glu Phe Ile Asn Glu Val Gly Val Val Thr 
        355                 360                 365             


Leu Ile Glu Ser Leu Leu Ser Phe Pro Ser Pro Glu Met Arg Lys Lys 
    370                 375                 380                 


Thr Val Ile Thr Leu Asn Pro Pro Ser Gly Asp Glu Arg Gln Arg Lys 
385                 390                 395                 400 


Ile Glu Leu His Val Lys His Met Cys Lys Glu Thr Met Ser Phe Pro 
                405                 410                 415     


Leu Asn Ser Pro Gly Gln Gln Ser Gly Leu Lys Ile Leu Gly Gln Leu 
            420                 425                 430         


Thr Thr Asp Phe Val His His Tyr Ile Val Ala Asn Tyr Phe Ser Glu 
        435                 440                 445             


Leu Phe His Leu Leu Ser Ser Gly Asn Cys Lys Thr Arg Asn Leu Val 
    450                 455                 460                 


Leu Lys Leu Leu Leu Asn Met Ser Glu Asn Pro Thr Ala Ala Arg Asp 
465                 470                 475                 480 


Met Ile Asn Met Lys Ala Leu Ala Ala Leu Lys Leu Ile Phe Asn Gln 
                485                 490                 495     


Lys Glu Ala Lys Ala Asn Leu Val Ser Gly Val Ala Ile Phe Ile Asn 
            500                 505                 510         


Ile Lys Glu His Ile Arg Lys Gly Ser Ile Val Val Val Asp His Leu 
        515                 520                 525             


Ser Tyr Asn Thr Leu Met Ala Ile Phe Arg Glu Val Lys Glu Ile Ile 
    530                 535                 540                 


Glu Thr Met 
545         


<210> 7960
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7960
Met Ala Phe Ser Gly Arg Ala Arg Pro Cys Ile Ile Pro Glu Asn Glu 
1               5                   10                  15      


Glu Ile Pro Arg Ala Ala Leu Asn Thr Val His Glu Ala Asn Gly Thr 
            20                  25                  30          


Glu Asp Glu Arg Ala Val Ser Lys Leu Gln Arg Arg His Ser Asp Val 
        35                  40                  45              


Lys Val Tyr Lys Glu Phe Cys Asp Phe Tyr Ala Lys Phe Asn Met Ala 
    50                  55                  60                  


Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly Phe Ala 
65                  70                  75                  80  


Pro Ala Glu Thr Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu Gln 
                85                  90                  95      


Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly Leu Phe 
            100                 105                 110         


Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu 
        115                 120                 125             


Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly Arg Val 
    130                 135                 140                 


Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg Cys Asp 
145                 150                 155                 160 


Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn Ala Gly 
                165                 170                 175     


Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg Gly Leu 
            180                 185                 190         


Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu Gln Pro 
        195                 200                 205             


Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn Cys Ala 
    210                 215                 220                 


Asn Cys Gly Gln Glu Gly Ser Asp Cys Arg Cys Thr Gly Ala Glu Arg 
225                 230                 235                 240 


Gly Ala Ile Leu Pro Ala Met Pro 
                245             


<210> 7961
<211> 206
<212> PRT
<213> Homo sapiens

<400> 7961
Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      


Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          


Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              


Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  


Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  


Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      


Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         


Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             


Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 


Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 


Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     


Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         


Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser 
        195                 200                 205     


<210> 7962
<211> 329
<212> PRT
<213> Homo sapiens

<400> 7962
Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu 
            20                  25                  30          


Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser Arg 
        35                  40                  45              


Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn 
    50                  55                  60                  


Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala Pro 
65                  70                  75                  80  


Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val Ile 
                85                  90                  95      


Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser 
            100                 105                 110         


Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys Met Ile 
        115                 120                 125             


Glu Met Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His Glu Phe 
    130                 135                 140                 


Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu Thr 
145                 150                 155                 160 


Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr Ala 
                165                 170                 175     


Ser Cys Ser Thr Phe Asn Ile Ser Gly Ala Ser Pro Ala Arg Gln Gln 
            180                 185                 190         


Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro Pro Pro 
        195                 200                 205             


Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys Gln Pro 
    210                 215                 220                 


Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys Pro Tyr 
225                 230                 235                 240 


Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu Lys Glu 
                245                 250                 255     


Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu Asp 
            260                 265                 270         


Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro Ala 
        275                 280                 285             


Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu Gln 
    290                 295                 300                 


Arg Pro Cys Gln Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu Asp 
305                 310                 315                 320 


Glu Ala Ile Glu Val Glu Ala Thr Val 
                325                 


<210> 7963
<211> 539
<212> PRT
<213> Homo sapiens

<400> 7963
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 7964
<211> 1185
<212> PRT
<213> Homo sapiens

<400> 7964
Met Cys Glu Val Met Pro Thr Ile Asn Glu Gly Asp Arg Leu Gly Pro 
1               5                   10                  15      


Pro His Gly Ala Asp Ala Asp Ala Asn Phe Glu Gln Leu Met Val Asn 
            20                  25                  30          


Met Leu Asp Glu Arg Glu Lys Leu Leu Glu Ser Leu Arg Glu Ser Gln 
        35                  40                  45              


Glu Thr Leu Ala Ala Thr Gln Ser Arg Leu Gln Asp Ala Ile His Glu 
    50                  55                  60                  


Arg Asp Gln Leu Gln Arg His Leu Asn Ser Ala Leu Pro Gln Glu Phe 
65                  70                  75                  80  


Ala Thr Leu Thr Arg Glu Leu Ser Met Cys Arg Glu Gln Leu Leu Glu 
                85                  90                  95      


Arg Glu Glu Glu Ile Ser Glu Leu Lys Ala Glu Arg Asn Asn Thr Arg 
            100                 105                 110         


Leu Leu Leu Glu His Leu Glu Cys Leu Val Ser Arg His Glu Arg Ser 
        115                 120                 125             


Leu Arg Met Thr Val Val Lys Arg Gln Ala Gln Ser Pro Ser Gly Val 
    130                 135                 140                 


Ser Ser Glu Val Glu Val Leu Lys Ala Leu Lys Ser Leu Phe Glu His 
145                 150                 155                 160 


His Lys Ala Leu Asp Glu Lys Val Arg Glu Arg Leu Arg Ala Ala Leu 
                165                 170                 175     


Glu Arg Val Thr Thr Leu Glu Glu Gln Leu Ala Gly Ala His Gln Gln 
            180                 185                 190         


Val Ser Ala Leu Gln Gln Gly Ala Gly Val Arg Asp Gly Ala Ala Glu 
        195                 200                 205             


Glu Glu Gly Thr Val Glu Leu Gly Pro Lys Arg Leu Trp Lys Glu Asp 
    210                 215                 220                 


Thr Gly Arg Val Glu Glu Leu Gln Glu Leu Leu Glu Lys Gln Asn Phe 
225                 230                 235                 240 


Glu Leu Ser Gln Ala Arg Glu Arg Leu Val Thr Leu Thr Thr Thr Val 
                245                 250                 255     


Thr Glu Leu Glu Glu Asp Leu Gly Thr Ala Arg Arg Asp Leu Ile Lys 
            260                 265                 270         


Ser Glu Glu Leu Ser Ser Lys His Gln Arg Asp Leu Arg Glu Ala Leu 
        275                 280                 285             


Ala Gln Lys Glu Asp Met Glu Glu Arg Ile Thr Thr Leu Glu Lys Arg 
    290                 295                 300                 


Tyr Leu Ala Ala Gln Arg Glu Ala Thr Ser Ile His Asp Leu Asn Asp 
305                 310                 315                 320 


Lys Leu Glu Asn Glu Leu Ala Asn Lys Glu Ser Leu His Arg Gln Cys 
                325                 330                 335     


Glu Glu Lys Ala Arg His Leu Gln Glu Leu Leu Glu Val Ala Glu Gln 
            340                 345                 350         


Lys Leu Gln Gln Thr Met Arg Lys Ala Glu Thr Leu Pro Glu Val Glu 
        355                 360                 365             


Ala Glu Leu Ala Gln Arg Ile Ala Ala Leu Thr Lys Ala Glu Glu Arg 
    370                 375                 380                 


His Gly Asn Ile Glu Glu His Leu Arg Gln Leu Glu Gly Gln Leu Glu 
385                 390                 395                 400 


Glu Lys Asn Gln Glu Leu Ala Arg Thr Ala Val Gln Val Arg Gln Arg 
                405                 410                 415     


Glu Lys Met Asn Glu Asp His Asn Lys Arg Leu Ser Asp Thr Val Asp 
            420                 425                 430         


Arg Leu Leu Ser Glu Ser Asn Glu Arg Leu Gln Leu His Leu Lys Glu 
        435                 440                 445             


Arg Met Ala Ala Leu Glu Glu Lys Asn Thr Leu Ile Gln Glu Leu Glu 
    450                 455                 460                 


Ser Ser Gln Arg Gln Ile Glu Glu Gln His His His Lys Gly Arg Leu 
465                 470                 475                 480 


Ser Glu Glu Ile Glu Lys Leu Arg Gln Glu Val Asp Gln Leu Lys Gly 
                485                 490                 495     


Arg Gly Gly Pro Phe Val Asp Gly Val His Ser Arg Ser His Met Gly 
            500                 505                 510         


Ser Ala Ala Asp Val Arg Phe Ser Leu Gly Thr Thr Thr His Ala Pro 
        515                 520                 525             


Pro Gly Val His Arg Arg Tyr Ser Ala Leu Arg Glu Glu Ser Ala Lys 
    530                 535                 540                 


Leu Ala Leu Pro Leu Thr Val Thr Leu Arg Ser Pro Thr Trp Met Arg 
545                 550                 555                 560 


Met Ser Gln Gly Val Cys Cys Asn Leu Glu Tyr His Ser Ser Gly Thr 
                565                 570                 575     


Leu Cys Gly Ser Ser Gly Pro Leu Pro Val Pro Glu Met Ile Gln Glu 
            580                 585                 590         


Glu Lys Glu Ser Thr Glu Leu Arg Ala Glu Glu Ile Glu Thr Arg Val 
        595                 600                 605             


Thr Ser Gly Ser Met Glu Ala Leu Asn Leu Lys Gln Leu Arg Lys Arg 
    610                 615                 620                 


Gly Ser Ile Pro Thr Ser Leu Thr Ala Leu Ser Leu Ala Ser Ala Ser 
625                 630                 635                 640 


Pro Pro Leu Ser Gly Arg Ser Thr Pro Lys Leu Thr Ser Arg Ser Ala 
                645                 650                 655     


Ala Gln Asp Leu Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp Leu 
            660                 665                 670         


Arg Lys His Arg Arg Lys Leu Leu Ser Pro Val Ser Arg Glu Glu Asn 
        675                 680                 685             


Arg Glu Asp Lys Ala Thr Ile Lys Cys Glu Thr Ser Pro Pro Ser Ser 
    690                 695                 700                 


Pro Arg Thr Leu Arg Leu Glu Lys Leu Gly His Pro Ala Leu Ser Gln 
705                 710                 715                 720 


Glu Glu Gly Lys Ser Ala Leu Glu Asp Gln Gly Ser Asn Pro Ser Ser 
                725                 730                 735     


Ser Asn Ser Ser Gln Asp Ser Leu His Lys Gly Ala Lys Arg Lys Gly 
            740                 745                 750         


Ile Lys Ser Ser Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Gly Arg 
        755                 760                 765             


Leu Ile Gln Leu Ser Arg Asp Gly Ala Thr Gly His Val Leu Leu Thr 
    770                 775                 780                 


Asp Ser Glu Phe Ser Met Gln Glu Pro Met Val Pro Ala Lys Leu Gly 
785                 790                 795                 800 


Thr Gln Ala Glu Lys Asp Arg Arg Leu Lys Lys Lys His Gln Leu Leu 
                805                 810                 815     


Glu Asp Ala Arg Arg Lys Gly Met Pro Phe Ala Gln Trp Asp Gly Pro 
            820                 825                 830         


Thr Val Val Ser Trp Leu Glu Leu Trp Val Gly Met Pro Ala Trp Tyr 
        835                 840                 845             


Val Ala Ala Cys Arg Ala Asn Val Lys Ser Gly Ala Ile Met Ser Ala 
    850                 855                 860                 


Leu Ser Asp Thr Glu Ile Gln Arg Glu Ile Gly Ile Ser Asn Ala Leu 
865                 870                 875                 880 


His Arg Leu Lys Leu Arg Leu Ala Ile Gln Glu Met Val Ser Leu Thr 
                885                 890                 895     


Ser Pro Ser Ala Pro Pro Thr Ser Arg Thr Ser Ser Gly Asn Val Trp 
            900                 905                 910         


Val Thr His Glu Glu Met Glu Thr Leu Glu Thr Ser Thr Lys Thr Asp 
        915                 920                 925             


Ser Glu Glu Gly Ser Trp Ala Gln Thr Leu Ala Tyr Gly Asp Met Asn 
    930                 935                 940                 


His Glu Trp Ile Gly Asn Glu Trp Leu Pro Ser Leu Gly Leu Pro Gln 
945                 950                 955                 960 


Tyr Arg Ser Tyr Phe Met Glu Cys Leu Val Asp Ala Arg Met Leu Asp 
                965                 970                 975     


His Leu Thr Lys Lys Asp Leu Arg Val His Leu Lys Met Val Asp Ser 
            980                 985                 990         


Phe His Arg Thr Ser Leu Gln Tyr  Gly Ile Met Cys Leu  Lys Arg Leu 
        995                 1000                 1005             


Asn Tyr  Asp Arg Lys Glu Leu  Glu Lys Arg Arg Glu  Glu Ser Gln 
    1010                 1015                 1020             


His Glu  Ile Lys Asp Val Leu  Val Trp Thr Asn Asp  Gln Val Val 
    1025                 1030                 1035             


His Trp  Val Gln Ser Ile Gly  Leu Arg Asp Tyr Ala  Gly Asn Leu 
    1040                 1045                 1050             


His Glu  Ser Gly Val His Gly  Ala Leu Leu Ala Leu  Asp Glu Asn 
    1055                 1060                 1065             


Phe Asp  His Asn Thr Leu Ala  Leu Ile Leu Gln Ile  Pro Thr Gln 
    1070                 1075                 1080             


Asn Thr  Gln Ala Arg Gln Val  Met Glu Arg Glu Phe  Asn Asn Leu 
    1085                 1090                 1095             


Leu Ala  Leu Gly Thr Asp Arg  Lys Leu Asp Asp Gly  Asp Asp Lys 
    1100                 1105                 1110             


Val Phe  Arg Arg Ala Pro Ser  Trp Arg Lys Arg Phe  Arg Pro Arg 
    1115                 1120                 1125             


Glu His  His Gly Arg Gly Gly  Met Leu Ser Ala Ser  Ala Glu Thr 
    1130                 1135                 1140             


Leu Pro  Ala Gly Phe Arg Val  Ser Thr Leu Gly Thr  Leu Gln Pro 
    1145                 1150                 1155             


Pro Pro  Ala Pro Pro Lys Lys  Ile Met Pro Glu Ala  His Ser His 
    1160                 1165                 1170             


Tyr Leu  Tyr Gly His Met Leu  Ser Ala Phe Arg Asp  
    1175                 1180                 1185 


<210> 7965
<211> 460
<212> PRT
<213> Homo sapiens

<400> 7965
Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys Asp 
1               5                   10                  15      


Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe His 
            20                  25                  30          


Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn Cys 
        35                  40                  45              


Gly His Arg Phe His Val Leu Val Ala Ser Gln Asp Phe Val Glu Ser 
    50                  55                  60                  


Val Leu Val Arg Thr Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile Val 
65                  70                  75                  80  


His Asp Lys Val Leu Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe Arg 
                85                  90                  95      


Ser Ser Pro Asp Leu Thr Gly Val Val Thr Ile Tyr Glu Asp Leu Arg 
            100                 105                 110         


Arg Lys Gly Leu Glu Phe Pro Met Thr Asp Leu Asp Met Leu Ser Pro 
        115                 120                 125             


Ile His Thr Pro Gln Arg Thr Val Phe Asn Ser Glu Thr Gln Ser Gly 
    130                 135                 140                 


Gln Asp Ser Val Gly Thr Asp Ser Ser Gln Gln Glu Asp Ser Gly Gln 
145                 150                 155                 160 


His Ala Ala Pro Leu Pro Ala Pro Pro Ile Leu Ser Gly Asp Thr Pro 
                165                 170                 175     


Ile Ala Pro Thr Pro Glu Gln Ile Gly Lys Leu Arg Ser Glu Leu Glu 
            180                 185                 190         


Met Val Ser Gly Asn Val Arg Val Met Ser Glu Met Leu Thr Glu Leu 
        195                 200                 205             


Val Pro Thr Gln Ala Glu Pro Ala Asp Leu Glu Leu Leu Gln Glu Leu 
    210                 215                 220                 


Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Val Leu Glu Leu Ile Pro 
225                 230                 235                 240 


Gln Ile Ala Asn Glu Gln Leu Thr Glu Glu Leu Leu Ile Val Asn Asp 
                245                 250                 255     


Asn Leu Asn Asn Val Phe Leu Arg His Glu Arg Phe Glu Arg Phe Arg 
            260                 265                 270         


Thr Gly Gln Thr Thr Lys Ala Pro Ser Glu Ala Glu Pro Ala Ala Asp 
        275                 280                 285             


Leu Ile Asp Met Gly Pro Asp Pro Ala Ala Thr Gly Asn Leu Ser Ser 
    290                 295                 300                 


Gln Leu Ala Gly Met Asn Leu Gly Ser Ser Ser Val Arg Ala Gly Leu 
305                 310                 315                 320 


Gln Ser Leu Glu Ala Ser Gly Arg Leu Glu Asp Glu Phe Asp Met Phe 
                325                 330                 335     


Ala Leu Thr Arg Gly Ser Ser Leu Ala Asp Gln Arg Lys Glu Val Lys 
            340                 345                 350         


Tyr Glu Ala Pro Gln Ala Thr Asp Gly Leu Ala Gly Ala Leu Asp Ala 
        355                 360                 365             


Arg Gln Gln Ser Thr Gly Ala Ile Pro Val Thr Gln Ala Cys Leu Met 
    370                 375                 380                 


Glu Asp Ile Glu Gln Trp Leu Ser Thr Asp Val Gly Asn Asp Ala Glu 
385                 390                 395                 400 


Glu Pro Lys Gly Val Thr Ser Glu Gly Lys Phe Asp Lys Phe Leu Glu 
                405                 410                 415     


Glu Arg Ala Lys Ala Ala Asp Arg Leu Pro Asn Leu Ser Ser Pro Ser 
            420                 425                 430         


Ala Glu Gly Pro Pro Gly Pro Pro Ser Gly Pro Ala Pro Arg Lys Lys 
        435                 440                 445             


Thr Gln Glu Lys Asp Asp Asp Met Leu Phe Ala Leu 
    450                 455                 460 


<210> 7966
<211> 59
<212> PRT
<213> Homo sapiens

<400> 7966
Met Met Met Lys Met Met Met Arg Met Lys Ile Arg Lys Ile Arg Tyr 
1               5                   10                  15      


His Cys Gln Arg Lys Gln Asn Leu Ile His Asn Asn Gly Asn Gly Leu 
            20                  25                  30          


Gly Ser Val Pro Val Glu Lys Leu Val Leu His Pro Ser Pro Ile Gln 
        35                  40                  45              


Asn Pro Gln Gln Ser Ala Val Val Ser Cys Glu 
    50                  55                  


<210> 7967
<211> 178
<212> PRT
<213> Homo sapiens

<400> 7967
Met Leu Gly Leu Asp Ala Cys Glu Leu Gly Ala Gln Leu Leu Glu Leu 
1               5                   10                  15      


Leu Arg Leu Ala Leu Cys Ala Arg Val Leu Leu Ala Asp Lys Glu Gly 
            20                  25                  30          


Gly Pro Pro Ala Val Asp Glu Val Leu Asp Glu Ala Val Pro Glu Tyr 
        35                  40                  45              


Arg Ala Pro Gly Arg Lys Ser Leu Leu Glu Ile Arg Gln Leu Asp Pro 
    50                  55                  60                  


Asp Asp Arg Ser Leu Ala Lys Tyr Lys Arg Val Leu Leu Gly Pro Leu 
65                  70                  75                  80  


Pro Pro Ala Val Asp Pro Ser Leu Pro Asn Val Gln Val Thr Arg Leu 
                85                  90                  95      


Thr Leu Leu Ser Glu Gln Ala Pro Gly Pro Val Val Met Asp Leu Thr 
            100                 105                 110         


Gly Asp Leu Ala Val Leu Lys Asp Gln Val Phe Val Leu Lys Glu Gly 
        115                 120                 125             


Val Asp Tyr Arg Val His Arg Glu Ile Val Ser Gly Leu Lys Cys Leu 
    130                 135                 140                 


His His Thr Tyr Arg Arg Gly Leu Arg Val Asp Lys Thr Val Tyr Met 
145                 150                 155                 160 


Val Gly Ser Tyr Gly Pro Ser Ala Gln Glu Tyr Glu Phe Val Thr Pro 
                165                 170                 175     


Val Glu 
        


<210> 7968
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7968
Met Asp Ser Val Arg Ser Gly Pro Phe Gly Gln Val Phe Arg Pro Asp 
1               5                   10                  15      


Asn Phe Ile Phe Gly Gln Cys Gly Ala Gly Asn Asn Trp Ala Lys Gly 
            20                  25                  30          


His Tyr Thr Glu Gly Ala Glu Leu Met Glu Ser Val Met Asp Val Val 
        35                  40                  45              


Arg Lys Glu Ala Glu Ser Cys Asp Cys Leu Gln Gly Phe Gln Leu Thr 
    50                  55                  60                  


His Ser Leu Gly Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Leu 
65                  70                  75                  80  


Ser Lys Ile Arg Glu Glu Tyr Pro Asp Arg Ile Ile Asn Thr Phe Ser 
                85                  90                  95      


Ile Leu Pro Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn 
            100                 105                 110         


Ala Thr Leu Ser Val His Gln Leu Ile Glu Asn Ala Asp Glu Thr Phe 
        115                 120                 125             


Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile Cys Ser Lys Thr Leu Lys 
    130                 135                 140                 


Leu Pro Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr 
145                 150                 155                 160 


Met Ser Gly Val Thr Thr Cys Leu Arg Phe Pro Gly Gln Leu Asn Ala 
                165                 170                 175     


Asp Leu Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His 
            180                 185                 190         


Phe Phe Met Pro Gly Phe Ala Pro Leu Thr Ser Arg Gly Ser Gln Gln 
        195                 200                 205             


Tyr Arg Ala Leu Thr Val Ala Glu Leu Thr Gln Gln Met Phe Asp Ala 
    210                 215                 220                 


Lys Asn Met Met Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr 
225                 230                 235                 240 


Ala Ala Ala Ile Phe Arg Gly Arg Met Pro Met Arg Glu Val Asp Glu 
                245                 250                 255     


Gln Met Phe Asn Ile Gln Asp Lys Asn Ser Ser Tyr Phe Ala Asp Trp 
            260                 265                 270         


Leu Pro Asn Asn Val Lys Thr Ala Val Cys Asp Ile Pro Pro Arg Gly 
        275                 280                 285             


Leu Lys Met Ser Ala Thr Phe Ile Gly Asn Asn Thr Ala Ile Gln Glu 
    290                 295                 300                 


Leu Phe Lys Arg Val Ser Glu Gln Phe Thr Ala Met Phe Arg Arg Lys 
305                 310                 315                 320 


Ala Phe Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met Glu Phe 
                325                 330                 335     


Thr Glu Ala Glu Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln 
            340                 345                 350         


Tyr Gln Asp Ala Thr Ala Glu Glu Glu Glu Asp Glu Glu Tyr Ala Glu 
        355                 360                 365             


Glu Glu Val Ala 
    370         


<210> 7969
<211> 191
<212> PRT
<213> Homo sapiens

<400> 7969
Met Ala Ala Ala Lys Asp Thr His Glu Asp His Asp Thr Ser Thr Glu 
1               5                   10                  15      


Asn Thr Asp Glu Ser Asn His Asp Pro Gln Phe Glu Pro Ile Val Ser 
            20                  25                  30          


Leu Pro Glu Gln Glu Ile Lys Thr Leu Glu Glu Asp Glu Glu Glu Leu 
        35                  40                  45              


Phe Lys Met Arg Ala Lys Leu Phe Arg Phe Ala Ser Glu Asn Asp Leu 
    50                  55                  60                  


Pro Glu Trp Lys Glu Arg Gly Thr Gly Asp Val Lys Leu Leu Lys His 
65                  70                  75                  80  


Lys Thr Leu Lys Ile Cys Ala Asn His Tyr Ile Thr Pro Met Met Glu 
                85                  90                  95      


Leu Lys Pro Asn Ala Gly Ser Asp Arg Ala Trp Val Trp Asn Thr His 
            100                 105                 110         


Ala Asp Phe Ala Asp Glu Cys Pro Lys Pro Glu Leu Leu Ala Ile Arg 
        115                 120                 125             


Phe Leu Asn Ala Glu Ser Glu Pro Arg Ala Leu Gly Thr Cys Leu Thr 
    130                 135                 140                 


Trp Gly Ser Pro Ala Trp Gln Arg Gly Gly Leu Cys Ala Thr Asn Ala 
145                 150                 155                 160 


Val Ala Phe Trp Gly Glu Gly Ala Val Thr Gly Lys Cys Val Val Trp 
                165                 170                 175     


Ala Ala Leu Pro Cys Cys Leu Gly Ala Met Pro Arg Leu Lys Pro 
            180                 185                 190     


<210> 7970
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7970
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val 
        115                 120         


<210> 7971
<211> 460
<212> PRT
<213> Homo sapiens

<400> 7971
Met Ala Ser Leu Leu Gln Ser Asp Arg Val Leu Tyr Leu Val Gln Gly 
1               5                   10                  15      


Glu Lys Lys Val Arg Ala Pro Leu Ser Gln Leu Tyr Phe Cys Arg Tyr 
            20                  25                  30          


Cys Ser Glu Leu Arg Ser Leu Glu Cys Val Ser His Glu Val Asp Ser 
        35                  40                  45              


His Tyr Cys Pro Ser Cys Leu Glu Asn Met Pro Ser Ala Glu Ala Lys 
    50                  55                  60                  


Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe Asp Cys Pro Gly Cys Met 
65                  70                  75                  80  


His Thr Leu Ser Thr Arg Ala Thr Ser Ile Ser Thr Gln Leu Pro Asp 
                85                  90                  95      


Asp Pro Ala Lys Thr Thr Met Lys Lys Ala Tyr Tyr Leu Ala Cys Gly 
            100                 105                 110         


Phe Cys Arg Trp Thr Ser Arg Asp Val Gly Met Ala Asp Lys Ser Val 
        115                 120                 125             


Ala Ser Gly Gly Trp Gln Glu Pro Glu Asn Pro His Thr Gln Arg Met 
    130                 135                 140                 


Asn Lys Leu Ile Glu Tyr Tyr Gln Gln Leu Ala Gln Lys Glu Lys Val 
145                 150                 155                 160 


Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg Arg Asn Tyr Met Pro Leu 
                165                 170                 175     


Ala Phe Ser Asp Lys Tyr Gly Leu Gly Thr Arg Leu Gln Arg Pro Arg 
            180                 185                 190         


Ala Gly Ala Ser Ile Ser Thr Leu Ala Gly Leu Ser Leu Lys Glu Gly 
        195                 200                 205             


Glu Asp Gln Lys Glu Ile Lys Ile Glu Pro Ala Gln Ala Val Asp Glu 
    210                 215                 220                 


Val Glu Pro Leu Pro Glu Asp Tyr Tyr Thr Arg Pro Val Asn Leu Thr 
225                 230                 235                 240 


Glu Val Thr Thr Leu Gln Gln Arg Leu Leu Gln Pro Asp Phe Gln Pro 
                245                 250                 255     


Val Cys Ala Ser Gln Leu Tyr Pro Arg His Lys His Leu Leu Ile Lys 
            260                 265                 270         


Arg Ser Leu Arg Cys Arg Lys Cys Glu His Asn Leu Ser Lys Pro Glu 
        275                 280                 285             


Phe Asn Pro Thr Ser Ile Lys Phe Lys Ile Gln Leu Val Ala Val Asn 
    290                 295                 300                 


Tyr Ile Pro Glu Val Arg Ile Met Ser Ile Pro Asn Leu Arg Tyr Met 
305                 310                 315                 320 


Lys Glu Ser Gln Val Leu Leu Thr Leu Thr Asn Pro Val Glu Asn Leu 
                325                 330                 335     


Thr His Val Thr Leu Phe Glu Cys Glu Glu Gly Asp Pro Asp Asp Ile 
            340                 345                 350         


Asn Ser Thr Ala Lys Val Val Val Pro Pro Lys Glu Leu Val Leu Ala 
        355                 360                 365             


Gly Lys Asp Ala Ala Ala Glu Tyr Asp Glu Leu Ala Glu Pro Gln Asp 
    370                 375                 380                 


Phe Gln Asp Asp Pro Asp Ile Ile Ala Phe Arg Lys Ala Asn Lys Val 
385                 390                 395                 400 


Gly Ile Phe Ile Lys Val Thr Pro Gln Arg Glu Glu Gly Glu Val Thr 
                405                 410                 415     


Val Cys Phe Lys Met Lys His Asp Phe Lys Asn Leu Ala Ala Pro Ile 
            420                 425                 430         


Arg Pro Ile Glu Glu Ser Asp Gln Gly Thr Glu Val Ile Trp Leu Thr 
        435                 440                 445             


Gln His Val Glu Leu Ser Leu Gly Pro Leu Leu Pro 
    450                 455                 460 


<210> 7972
<211> 1111
<212> PRT
<213> Homo sapiens

<400> 7972
Met Glu Met Asp Ala Pro Arg Pro Pro Ser Leu Ala Val Pro Gly Ala 
1               5                   10                  15      


Ala Ser Arg Pro Gly Arg Leu Leu Asp Gly Gly His Gly Arg Gln Gln 
            20                  25                  30          


Val Gln Ala Leu Ser Ser Gln Leu Leu Glu Val Ile Pro Asp Ser Met 
        35                  40                  45              


Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His Gly 
    50                  55                  60                  


Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu Ala 
65                  70                  75                  80  


Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp Arg Thr 
                85                  90                  95      


Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln Arg 
            100                 105                 110         


His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu Gly 
        115                 120                 125             


Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu Thr 
    130                 135                 140                 


Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr Arg 
145                 150                 155                 160 


Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe Leu 
                165                 170                 175     


Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile Gly 
            180                 185                 190         


Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg Leu 
        195                 200                 205             


Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro Leu 
    210                 215                 220                 


Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg Leu 
225                 230                 235                 240 


Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val Ala 
                245                 250                 255     


Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys Arg 
            260                 265                 270         


Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys Lys 
        275                 280                 285             


Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn Leu 
    290                 295                 300                 


Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser Gly 
305                 310                 315                 320 


Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly Phe 
                325                 330                 335     


Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu Asp 
            340                 345                 350         


Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg Ala 
        355                 360                 365             


Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly Met 
    370                 375                 380                 


Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala Glu 
385                 390                 395                 400 


Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe Arg 
                405                 410                 415     


Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro Arg 
            420                 425                 430         


Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu Gly 
        435                 440                 445             


Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr Glu 
    450                 455                 460                 


Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly Ala 
465                 470                 475                 480 


Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser Val 
                485                 490                 495     


Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala Ala 
            500                 505                 510         


Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr Glu 
        515                 520                 525             


Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg Ser 
    530                 535                 540                 


Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val Phe 
545                 550                 555                 560 


Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu Leu 
                565                 570                 575     


Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr Gln 
            580                 585                 590         


Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val Cys 
        595                 600                 605             


Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His Thr 
    610                 615                 620                 


Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu Ala 
625                 630                 635                 640 


Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu Gln 
                645                 650                 655     


Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu Ser 
            660                 665                 670         


Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg Lys 
        675                 680                 685             


Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu Leu 
    690                 695                 700                 


Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser Leu 
705                 710                 715                 720 


Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg Ser 
                725                 730                 735     


Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn Ser 
            740                 745                 750         


Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile Asn 
        755                 760                 765             


Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn Thr Val Arg Asp Asp 
    770                 775                 780                 


Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser Asn Arg Thr Leu Ser 
785                 790                 795                 800 


Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro Met Gly Ala Gln Arg 
                805                 810                 815     


Met Ala Asp Leu Lys Gln Asn Arg Ser Leu Lys Glu Leu Met Phe Ser 
            820                 825                 830         


Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys Ala Leu Ala Glu Ala Leu 
        835                 840                 845             


Lys Val Asn Gln Gly Leu Glu Ser Leu Asp Leu Gln Ser Asn Ser Ile 
    850                 855                 860                 


Ser Asp Ala Gly Val Ala Ala Leu Met Gly Ala Leu Cys Thr Asn Gln 
865                 870                 875                 880 


Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn Ser Ile Ser Pro Glu Gly 
                885                 890                 895     


Ala Gln Ala Ile Ala His Ala Leu Cys Ala Asn Ser Thr Leu Lys Asn 
            900                 905                 910         


Leu Asp Leu Thr Ala Asn Leu Leu His Asp Gln Gly Ala Arg Ala Ile 
        915                 920                 925             


Ala Val Ala Val Arg Glu Asn Arg Thr Leu Thr Ser Leu His Leu Gln 
    930                 935                 940                 


Trp Asn Phe Ile Gln Ala Gly Ala Ala Gln Ala Leu Gly Gln Ala Leu 
945                 950                 955                 960 


Gln Leu Asn Arg Ser Leu Thr Ser Leu Asp Leu Gln Glu Asn Ala Ile 
                965                 970                 975     


Gly Asp Asp Gly Ala Cys Ala Val Ala Arg Ala Leu Lys Val Asn Thr 
            980                 985                 990         


Ala Leu Thr Ala Leu Tyr Leu Gln  Val Ala Ser Ile Gly  Ala Ser Gly 
        995                 1000                 1005             


Ala Gln  Val Leu Gly Glu Ala  Leu Ala Val Asn Arg  Thr Leu Glu 
    1010                 1015                 1020             


Ile Leu  Asp Leu Arg Gly Asn  Ala Ile Gly Val Ala  Gly Ala Lys 
    1025                 1030                 1035             


Ala Leu  Ala Asn Ala Leu Lys  Val Asn Ser Ser Leu  Arg Arg Leu 
    1040                 1045                 1050             


Asn Leu  Gln Glu Asn Ser Leu  Gly Met Asp Gly Ala  Ile Cys Ile 
    1055                 1060                 1065             


Ala Thr  Ala Leu Ser Gly Asn  His Arg Leu Gln His  Ile Asn Leu 
    1070                 1075                 1080             


Gln Gly  Asn His Ile Gly Asp  Ser Gly Ala Arg Met  Ile Ser Glu 
    1085                 1090                 1095             


Ala Ile  Lys Thr Asn Ala Pro  Thr Cys Thr Val Glu  Met 
    1100                 1105                 1110     


<210> 7973
<211> 807
<212> PRT
<213> Homo sapiens

<400> 7973
Met Leu Glu Arg Arg Ala Leu Leu Trp Gln Arg Glu Ala Gly Pro Gly 
1               5                   10                  15      


Trp Gly Asp Arg Ala Arg Ala Gly Thr Gly Gly Ala Gly Gly Gly Cys 
            20                  25                  30          


Gly Gly Ala Met Ala Glu Arg Gly Pro Ala Phe Cys Gly Leu Tyr Asp 
        35                  40                  45              


Thr Ser Ser Leu Leu Arg Tyr Cys Asn Asp Asp Asn Leu Ser Gly Thr 
    50                  55                  60                  


Ser Gly Met Glu Val Asp Asp Arg Val Ser Ala Leu Glu Gln Arg Leu 
65                  70                  75                  80  


Gln Leu Gln Glu Asp Glu Leu Ala Val Leu Lys Ala Ala Leu Ala Asp 
                85                  90                  95      


Ala Leu Arg Arg Leu Arg Ala Cys Glu Glu Gln Gly Ala Ala Leu Arg 
            100                 105                 110         


Ala Arg Gly Thr Pro Lys Gly Arg Ala Pro Pro Arg Leu Gly Thr Thr 
        115                 120                 125             


Ala Ser Val Cys Gln Leu Leu Lys Gly Leu Pro Thr Arg Thr Pro Leu 
    130                 135                 140                 


Asn Gly Ser Gly Pro Pro Arg Arg Val Gly Gly Tyr Ala Thr Ser Pro 
145                 150                 155                 160 


Ser Ser Pro Lys Lys Glu Ala Thr Ser Gly Arg Ser Ser Val Arg Arg 
                165                 170                 175     


Tyr Leu Ser Pro Glu Arg Leu Ala Ser Val Arg Arg Glu Asp Pro Arg 
            180                 185                 190         


Ser Arg Thr Thr Ser Ser Ser Ser Asn Cys Ser Ala Lys Lys Glu Gly 
        195                 200                 205             


Lys Thr Lys Glu Val Ile Phe Ser Val Glu Asp Gly Ser Val Lys Met 
    210                 215                 220                 


Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu Ala 
225                 230                 235                 240 


Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg Leu 
                245                 250                 255     


Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala Asn 
            260                 265                 270         


Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser Val 
        275                 280                 285             


Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu Gly 
    290                 295                 300                 


His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val Thr 
305                 310                 315                 320 


Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys Glu Gly Lys Pro Leu 
                325                 330                 335     


Pro Pro His Val Arg Ile Trp Asp Ser Val Ser Leu Ser Thr Leu His 
            340                 345                 350         


Val Leu Gly Leu Gly Val Phe Asp Arg Ala Val Cys Cys Val Gly Phe 
        355                 360                 365             


Ser Lys Ser Asn Gly Gly Asn Leu Leu Cys Ala Val Asp Glu Ser Asn 
    370                 375                 380                 


Asp His Met Leu Ser Val Trp Asp Trp Ala Lys Glu Thr Lys Val Val 
385                 390                 395                 400 


Asp Val Lys Cys Ser Asn Glu Ala Val Leu Val Ala Thr Phe His Pro 
                405                 410                 415     


Thr Asp Pro Thr Val Leu Ile Thr Cys Gly Lys Ser His Ile Tyr Phe 
            420                 425                 430         


Trp Thr Leu Glu Gly Gly Ser Leu Ser Lys Arg Gln Gly Leu Phe Glu 
        435                 440                 445             


Lys His Glu Lys Pro Lys Tyr Val Leu Cys Val Thr Phe Leu Glu Gly 
    450                 455                 460                 


Gly Asp Val Val Thr Gly Asp Ser Gly Gly Asn Leu Tyr Val Trp Gly 
465                 470                 475                 480 


Lys Gly Gly Asn Arg Ile Thr Gln Ala Val Leu Gly Ala His Asp Gly 
                485                 490                 495     


Gly Val Phe Gly Leu Cys Ala Leu Arg Asp Gly Thr Leu Val Ser Gly 
            500                 505                 510         


Gly Gly Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly Phe Ser 
        515                 520                 525             


Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala Thr His 
    530                 535                 540                 


Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu Val His 
545                 550                 555                 560 


Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile Ile Glu 
                565                 570                 575     


Asp Pro Ala Arg Ser Ala Gly Phe His Pro Ser Gly Ser Val Leu Ala 
            580                 585                 590         


Val Gly Thr Val Thr Gly Arg Trp Leu Leu Leu Asp Thr Glu Thr His 
        595                 600                 605             


Asp Leu Val Ala Ile His Thr Asp Gly Asn Glu Gln Ile Ser Val Val 
    610                 615                 620                 


Ser Phe Ser Pro Asp Gly Ala Tyr Leu Ala Val Gly Ser His Asp Asn 
625                 630                 635                 640 


Leu Val Tyr Val Tyr Thr Val Asp Gln Gly Gly Arg Lys Val Ser Arg 
                645                 650                 655     


Leu Gly Lys Cys Ser Gly His Ser Ser Phe Ile Thr His Leu Asp Trp 
            660                 665                 670         


Ala Gln Asp Ser Ser Cys Phe Val Thr Asn Ser Gly Asp Tyr Glu Ile 
        675                 680                 685             


Leu Tyr Trp Asp Pro Ala Thr Cys Lys Gln Ile Thr Ser Ala Asp Ala 
    690                 695                 700                 


Val Arg Asn Met Glu Trp Ala Thr Ala Thr Cys Val Leu Gly Phe Gly 
705                 710                 715                 720 


Val Phe Gly Ile Trp Ser Glu Gly Ala Asp Gly Thr Asp Ile Asn Ala 
                725                 730                 735     


Val Ala Arg Ser His Asp Gly Lys Leu Leu Ala Ser Ala Asp Asp Phe 
            740                 745                 750         


Gly Lys Val His Leu Phe Ser Tyr Pro Cys Cys Gln Pro Arg Ala Leu 
        755                 760                 765             


Ser His Lys Tyr Gly Gly His Ser Ser His Val Thr Asn Val Ala Phe 
    770                 775                 780                 


Leu Trp Asp Asp Ser Met Ala Leu Thr Thr Gly Gly Lys Asp Thr Ser 
785                 790                 795                 800 


Val Leu Gln Trp Arg Val Val 
                805         


<210> 7974
<211> 470
<212> PRT
<213> Homo sapiens

<400> 7974
Met Glu Glu Thr Ile Lys Asp Pro Pro Thr Ser Ala Val Leu Leu Asp 
1               5                   10                  15      


His Cys His Phe Ser Gln Val Ile Phe Asn Ser Val Glu Lys Phe Tyr 
            20                  25                  30          


Ile Pro Gly Gly Asp Val Thr Cys His Tyr Thr Phe Thr Gln His Phe 
        35                  40                  45              


Ile Pro Arg Arg Lys Asp Trp Ile Gly Ile Phe Arg Ala Phe Lys Cys 
    50                  55                  60                  


Phe Gln Asp Lys Leu Glu Gln Glu Leu Leu Lys Trp Arg Ser Gln Gly 
65                  70                  75                  80  


Gln Lys Leu Gln Val Gly Trp Lys Thr Thr Arg Glu Tyr Tyr Thr Phe 
                85                  90                  95      


Met Trp Val Thr Leu Pro Ile Asp Leu Asn Asn Lys Ser Ala Lys Gln 
            100                 105                 110         


Gln Glu Val Gln Phe Lys Ala Tyr Tyr Leu Pro Lys Asp Asp Glu Tyr 
        115                 120                 125             


Tyr Gln Phe Cys Tyr Val Asp Glu Asp Gly Val Val Arg Gly Ala Ser 
    130                 135                 140                 


Ile Pro Phe Gln Phe Arg Pro Glu Asn Glu Glu Asp Ile Leu Val Val 
145                 150                 155                 160 


Thr Thr Gln Gly Glu Val Glu Glu Ile Glu Gln His Asn Lys Glu Leu 
                165                 170                 175     


Cys Lys Glu Asn Gln Glu Leu Lys Asp Ser Cys Ile Ser Leu Gln Lys 
            180                 185                 190         


Gln Asn Ser Asp Met Gln Ala Glu Leu Gln Lys Lys Gln Glu Glu Leu 
        195                 200                 205             


Glu Thr Leu Gln Ser Ile Asn Lys Lys Leu Glu Leu Lys Val Lys Glu 
    210                 215                 220                 


Gln Lys Asp Tyr Trp Glu Thr Glu Leu Leu Gln Leu Lys Glu Gln Asn 
225                 230                 235                 240 


Gln Lys Met Ser Ser Glu Asn Glu Lys Met Gly Ile Arg Val Asp Gln 
                245                 250                 255     


Leu Gln Ala Gln Leu Ser Thr Gln Glu Lys Glu Met Glu Lys Leu Val 
            260                 265                 270         


Gln Gly Asp Gln Asp Lys Thr Glu Gln Leu Glu Gln Leu Lys Lys Glu 
        275                 280                 285             


Asn Asp His Leu Phe Leu Ser Leu Thr Glu Gln Arg Lys Asp Gln Lys 
    290                 295                 300                 


Lys Leu Glu Gln Thr Val Glu Gln Met Lys Gln Asn Glu Thr Thr Ala 
305                 310                 315                 320 


Met Lys Lys Gln Gln Glu Leu Met Asp Glu Asn Phe Asp Leu Ser Lys 
                325                 330                 335     


Arg Leu Ser Glu Asn Glu Ile Ile Cys Asn Ala Leu Gln Arg Gln Lys 
            340                 345                 350         


Glu Arg Leu Glu Gly Glu Asn Asp Leu Leu Lys Arg Glu Asn Ser Arg 
        355                 360                 365             


Leu Leu Ser Tyr Met Gly Leu Asp Phe Asn Ser Leu Pro Tyr Gln Val 
    370                 375                 380                 


Pro Thr Ser Asp Glu Gly Gly Ala Arg Gln Asn Pro Gly Leu Ala Tyr 
385                 390                 395                 400 


Gly Asn Pro Tyr Ser Gly Ile Gln Glu Ser Ser Ser Pro Ser Pro Leu 
                405                 410                 415     


Ser Ile Lys Lys Cys Pro Ile Cys Lys Ala Asp Asp Ile Cys Asp His 
            420                 425                 430         


Thr Leu Glu Gln Gln Gln Met Gln Pro Leu Cys Phe Asn Cys Pro Ile 
        435                 440                 445             


Cys Asp Lys Ile Phe Pro Ala Thr Glu Lys Gln Ile Phe Glu Asp His 
    450                 455                 460                 


Val Phe Cys His Ser Leu 
465                 470 


<210> 7975
<211> 340
<212> PRT
<213> Homo sapiens

<400> 7975
Met Ser Lys Thr His Asp His Gln Leu Glu Ser Ser Leu Ser Pro Val 
1               5                   10                  15      


Glu Val Phe Ala Lys Thr Ser Ala Ser Leu Glu Met Asn Gln Gly Val 
            20                  25                  30          


Ser Glu Glu Arg Ile His Leu Gly Ser Ser Pro Lys Lys Gly Gly Asn 
        35                  40                  45              


Cys Asp Leu Ser His Gln Glu Arg Leu Gln Ser Lys Ser Leu His Leu 
    50                  55                  60                  


Ser Pro Gln Glu Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp 
65                  70                  75                  80  


Arg Arg Ala Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro 
                85                  90                  95      


Ile His Gln Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu 
            100                 105                 110         


Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe 
        115                 120                 125             


Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser 
    130                 135                 140                 


Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys 
145                 150                 155                 160 


His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe 
                165                 170                 175     


Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val 
            180                 185                 190         


Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr 
        195                 200                 205             


Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu 
    210                 215                 220                 


Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro 
225                 230                 235                 240 


Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro 
                245                 250                 255     


Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met 
            260                 265                 270         


Glu Leu Val Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala 
        275                 280                 285             


Phe Met Asp Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu 
    290                 295                 300                 


Gly Lys Arg Ser Met Gln Gln Leu Asp Pro Ser Pro Ala Arg Lys Leu 
305                 310                 315                 320 


Leu Lys Leu Gln Leu Gln Asn Pro Pro Ala Ile His Gly Ser Gly Ser 
                325                 330                 335     


Gly Ser Cys Gln 
            340 


<210> 7976
<211> 173
<212> PRT
<213> Homo sapiens

<400> 7976
Met Thr His Val Ala Ser Gln Phe Ala Ser Ser Tyr Val Phe Tyr Trp 
1               5                   10                  15      


Arg Asp Tyr Phe Glu Asp Gln Pro Leu Leu Tyr Pro Pro Gly Phe Asp 
            20                  25                  30          


Gly Arg Val Val Val Tyr Pro Ser Asn Gln Thr Leu Lys Asp Tyr Leu 
        35                  40                  45              


Ser Trp Arg Gln Ala Asp Cys His Ile Asn Asn Leu Tyr Asn Thr Val 
    50                  55                  60                  


Phe Trp Ala Leu Ile Gln Gln Ser Gly Leu Thr Pro Val Gln Ala Gln 
65                  70                  75                  80  


Gly Arg Leu Gln Gly Thr Leu Ala Ala Asp Lys Asn Glu Ile Leu Phe 
                85                  90                  95      


Ser Glu Phe Asn Ile Asn Tyr Asn Asn Glu Leu Pro Met Tyr Arg Lys 
            100                 105                 110         


Gly Thr Val Leu Ile Trp Gln Lys Val Asp Glu Val Met Thr Lys Glu 
        115                 120                 125             


Ile Lys Leu Pro Thr Glu Met Glu Gly Lys Lys Met Ala Val Thr Arg 
    130                 135                 140                 


Thr Arg Thr Lys Pro Val Pro Leu His Cys Asp Ile Ile Gly Asp Ala 
145                 150                 155                 160 


Phe Trp Lys Glu His Pro Glu Ile Leu Asp Glu Asp Ser 
                165                 170             


<210> 7977
<211> 94
<212> PRT
<213> Homo sapiens

<400> 7977
Met Glu Met Glu Ser Ala Ala Ala Ser Thr Arg Phe His Gln Pro His 
1               5                   10                  15      


Met Glu Arg Lys Met Ser Ala Met Ala Cys Glu Ile Phe Asn Glu Leu 
            20                  25                  30          


Arg Leu Glu Gly Lys Leu Cys Asp Val Val Ile Lys Val Asn Gly Phe 
        35                  40                  45              


Glu Phe Ser Ala His Lys Asn Ile Leu Cys Ser Cys Ser Ser Tyr Phe 
    50                  55                  60                  


Arg Ala Leu Phe Thr Ser Gly Trp Asn Asn Thr Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Asn Ile Pro Gly Ile Ser Pro Asp Met Met Lys Leu Ile Ile 
                85                  90                  


<210> 7978
<211> 523
<212> PRT
<213> Homo sapiens

<400> 7978
Met Asn Gln Pro Cys Asn Ser Met Glu Pro Arg Val Met Asp Asp Asp 
1               5                   10                  15      


Met Leu Lys Leu Ala Val Gly Asp Gln Gly Pro Gln Glu Glu Ala Gly 
            20                  25                  30          


Gln Leu Ala Lys Gln Glu Gly Ile Leu Phe Lys Asp Val Leu Ser Leu 
        35                  40                  45              


Gln Leu Asp Phe Arg Asn Ile Leu Arg Ile Asp Asn Leu Trp Gln Phe 
    50                  55                  60                  


Glu Asn Leu Arg Lys Leu Gln Leu Asp Asn Asn Ile Ile Glu Lys Ile 
65                  70                  75                  80  


Glu Gly Leu Glu Asn Leu Ala His Leu Val Trp Leu Asp Leu Ser Phe 
                85                  90                  95      


Asn Asn Ile Glu Thr Ile Glu Gly Leu Asp Thr Leu Val Asn Leu Glu 
            100                 105                 110         


Asp Leu Ser Leu Phe Asn Asn Arg Ile Ser Lys Ile Asp Ser Leu Asp 
        115                 120                 125             


Ala Leu Val Lys Leu Gln Val Leu Ser Leu Gly Asn Asn Arg Ile Asp 
    130                 135                 140                 


Asn Met Met Asn Ile Ile Tyr Leu Arg Arg Phe Lys Cys Leu Arg Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Arg Asn Pro Ile Ser Glu Ala Glu Asp Tyr Lys Met 
                165                 170                 175     


Phe Ile Cys Ala Tyr Leu Pro Asp Leu Met Tyr Leu Asp Tyr Arg Arg 
            180                 185                 190         


Ile Asp Asp His Thr Lys Lys Leu Ala Glu Ala Lys His Gln Tyr Ser 
        195                 200                 205             


Ile Asp Glu Leu Lys His Gln Glu Asn Leu Met Gln Ala Gln Leu Glu 
    210                 215                 220                 


Asp Glu Gln Ala Gln Arg Glu Glu Leu Glu Lys His Lys Thr Ala Phe 
225                 230                 235                 240 


Val Glu His Leu Asn Gly Ser Phe Leu Phe Asp Ser Met Tyr Ala Glu 
                245                 250                 255     


Asp Ser Glu Gly Asn Asn Leu Ser Tyr Leu Pro Gly Val Gly Glu Leu 
            260                 265                 270         


Leu Glu Thr Tyr Lys Asp Lys Phe Val Ile Ile Cys Val Asn Ile Phe 
        275                 280                 285             


Glu Tyr Gly Leu Lys Gln Gln Glu Lys Arg Lys Thr Glu Leu Asp Thr 
    290                 295                 300                 


Phe Ser Glu Cys Val Arg Glu Ala Ile Gln Glu Asn Gln Glu Gln Gly 
305                 310                 315                 320 


Lys Arg Lys Ile Ala Lys Phe Glu Glu Lys His Leu Ser Ser Leu Ser 
                325                 330                 335     


Ala Ile Arg Glu Glu Leu Glu Leu Pro Asn Ile Glu Lys Met Ile Leu 
            340                 345                 350         


Glu Cys Ser Ala Asp Ile Ser Glu Leu Phe Asp Ala Leu Met Thr Leu 
        355                 360                 365             


Glu Met Gln Leu Val Glu Gln Leu Glu Glu Thr Ile Asn Met Phe Glu 
    370                 375                 380                 


Arg Asn Ile Val Asp Met Val Gly Leu Phe Ile Glu Asn Val Gln Ser 
385                 390                 395                 400 


Leu Met Ala Gln Cys Arg Asp Leu Glu Asn His His His Glu Lys Leu 
                405                 410                 415     


Leu Glu Ile Ser Ile Ser Thr Leu Glu Lys Ile Val Glu Gly Asp Leu 
            420                 425                 430         


Asp Glu Asp Leu Pro Asn Asp Leu Arg Ala Leu Phe Val Asp Lys Asp 
        435                 440                 445             


Thr Ile Val Asn Ala Val Gly Ala Ser His Asp Ile His Leu Leu Lys 
    450                 455                 460                 


Ile Asp Asn Arg Glu Asp Glu Leu Val Thr Arg Ile Asn Ser Trp Cys 
465                 470                 475                 480 


Thr Arg Leu Ile Asp Arg Ile His Lys Asp Glu Ile Met Arg Asn Arg 
                485                 490                 495     


Lys Arg Val Lys Glu Ile Asn Gln Tyr Ile Asp His Met Gln Ser Glu 
            500                 505                 510         


Leu Asp Asn Leu Glu Cys Gly Asp Ile Leu Asp 
        515                 520             


<210> 7979
<211> 123
<212> PRT
<213> Homo sapiens

<400> 7979
Met Gly Thr Gly Asp Phe Ile Cys Ile Ser Met Thr Gly Gly Ala Pro 
1               5                   10                  15      


Trp Gly Phe Arg Leu Gln Gly Gly Lys Glu Gln Lys Gln Pro Leu Gln 
            20                  25                  30          


Val Ala Lys Ile Arg Asn Gln Ser Lys Ala Ser Gly Ser Gly Leu Cys 
        35                  40                  45              


Glu Gly Asp Glu Val Val Ser Ile Asn Gly Asn Pro Cys Ala Asp Leu 
    50                  55                  60                  


Thr Tyr Pro Glu Val Ile Lys Leu Met Glu Ser Ile Thr Asp Ser Leu 
65                  70                  75                  80  


Gln Met Leu Ile Lys Arg Arg Val Gly Ala Pro Phe Leu Phe Leu Glu 
                85                  90                  95      


Asp Gln Ser His Pro Pro Phe Leu His Leu Leu Gly Tyr Thr Ser Leu 
            100                 105                 110         


Leu Ile Val Thr Leu Val Asn Gln Pro Met Asp 
        115                 120             


<210> 7980
<211> 381
<212> PRT
<213> Homo sapiens

<400> 7980
Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 
1               5                   10                  15      


Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 
            20                  25                  30          


Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 
        35                  40                  45              


Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 
    50                  55                  60                  


Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 
65                  70                  75                  80  


Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 
                85                  90                  95      


Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 
            100                 105                 110         


Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 
        115                 120                 125             


Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 
    130                 135                 140                 


Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 
145                 150                 155                 160 


Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 
                165                 170                 175     


Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 
            180                 185                 190         


Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 
        195                 200                 205             


Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 
    210                 215                 220                 


Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 
225                 230                 235                 240 


Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 
                245                 250                 255     


Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 
            260                 265                 270         


Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 
        275                 280                 285             


Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 
    290                 295                 300                 


Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 
305                 310                 315                 320 


Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 
                325                 330                 335     


Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Glu Phe Cys 
            340                 345                 350         


Ser Leu Glu Gly Ile Glu Cys Gln Ala Ser Glu Pro Lys Leu Ser His 
        355                 360                 365             


His Ile Pro Ser Asp Leu His Val Tyr Ile Gln Met Ala 
    370                 375                 380     


<210> 7981
<211> 204
<212> PRT
<213> Homo sapiens

<400> 7981
Met Val Met Ala Glu Gly Thr Ala Val Leu Arg Arg Asn Arg Pro Gly 
1               5                   10                  15      


Thr Lys Ala Gln Tyr Ile Gln Gln Asn Ile Arg Ala Asp Cys Ser Asn 
            20                  25                  30          


Ile Asp Lys Ile Leu Glu Pro Pro Glu Gly Gln Asp Glu Gly Val Trp 
        35                  40                  45              


Lys Tyr Glu His Leu Arg Gln Phe Cys Leu Glu Leu Asn Gly Leu Ala 
    50                  55                  60                  


Val Lys Leu Gln Ser Glu Cys His Pro Asp Thr Cys Thr Gln Met Thr 
65                  70                  75                  80  


Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala His Lys Thr Pro Lys 
                85                  90                  95      


Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr Leu Asp Gly Ala Ala 
            100                 105                 110         


Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser Arg Val Ser Ile Lys 
        115                 120                 125             


Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys Arg Arg Ile Tyr Arg 
    130                 135                 140                 


Ile Phe Ser His Ala Tyr Phe His His Arg Gln Ile Phe Asp Glu Tyr 
145                 150                 155                 160 


Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr Lys Phe Val Met Lys 
                165                 170                 175     


Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val Pro Ile Leu Glu Glu 
            180                 185                 190         


Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu Ala 
        195                 200                 


<210> 7982
<211> 430
<212> PRT
<213> Homo sapiens

<400> 7982
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210> 7983
<211> 1062
<212> PRT
<213> Homo sapiens

<400> 7983
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg 
            100                 105                 110         


Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys 
        115                 120                 125             


Thr Glu Ala Gln Ala Phe Thr Glu Thr Lys Gly Asn Val Ile Cys Leu 
    130                 135                 140                 


Gly Lys Glu Val Phe Lys Gly Lys Lys Pro Asp Lys Asp Asn Arg Cys 
145                 150                 155                 160 


Arg Tyr Ile Leu Lys Thr Lys Phe Arg Glu Met Trp Lys Ser Trp Pro 
                165                 170                 175     


Gly Asp Ser Lys Glu Val Gln Val Met Ala Glu Arg Tyr Lys Met Leu 
            180                 185                 190         


Ile Pro Phe Ser Asn Pro Arg Val Leu Pro Gly Pro Phe Ser Tyr Thr 
        195                 200                 205             


Val Val Leu Tyr Gly Pro Ala Gly Leu Gly Lys Thr Thr Leu Ala Gln 
    210                 215                 220                 


Lys Leu Met Leu Asp Trp Ala Glu Asp Asn Leu Ile His Lys Phe Lys 
225                 230                 235                 240 


Tyr Ala Phe Tyr Leu Ser Cys Arg Glu Leu Ser Arg Leu Gly Pro Cys 
                245                 250                 255     


Ser Phe Ala Glu Leu Val Phe Arg Asp Trp Pro Glu Leu Gln Asp Asp 
            260                 265                 270         


Ile Pro His Ile Leu Ala Gln Ala Arg Lys Ile Leu Phe Val Ile Asp 
        275                 280                 285             


Gly Phe Asp Glu Leu Gly Ala Ala Pro Gly Ala Leu Ile Glu Asp Ile 
    290                 295                 300                 


Cys Gly Asp Trp Glu Lys Lys Lys Pro Val Pro Val Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Leu Asn Arg Val Met Leu Pro Lys Ala Ala Leu Leu Val Thr Thr 
                325                 330                 335     


Arg Pro Arg Ala Leu Arg Asp Leu Arg Ile Leu Ala Glu Glu Pro Ile 
            340                 345                 350         


Tyr Ile Arg Val Glu Gly Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe 
        355                 360                 365             


Leu Arg His Phe Gly Asp Glu Asp Gln Ala Met Arg Ala Phe Glu Leu 
    370                 375                 380                 


Met Arg Ser Asn Ala Ala Leu Phe Gln Leu Gly Ser Ala Pro Ala Val 
385                 390                 395                 400 


Cys Trp Ile Val Cys Thr Thr Leu Lys Leu Gln Met Glu Lys Gly Glu 
                405                 410                 415     


Asp Pro Val Pro Thr Cys Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe 
            420                 425                 430         


Leu Cys Ser Arg Phe Pro Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg 
        435                 440                 445             


Thr Leu Ser Leu Leu Ala Ala Gln Gly Leu Trp Ala Gln Thr Ser Val 
    450                 455                 460                 


Leu His Arg Glu Asp Leu Glu Arg Leu Gly Val Gln Glu Ser Asp Leu 
465                 470                 475                 480 


Arg Leu Phe Leu Asp Gly Asp Ile Leu Arg Gln Asp Arg Val Ser Lys 
                485                 490                 495     


Gly Cys Tyr Ser Phe Ile His Leu Ser Phe Gln Gln Phe Leu Thr Ala 
            500                 505                 510         


Leu Phe Tyr Thr Leu Glu Lys Glu Glu Glu Glu Asp Arg Asp Gly His 
        515                 520                 525             


Thr Trp Asp Ile Gly Asp Val Gln Lys Leu Leu Ser Gly Val Glu Arg 
    530                 535                 540                 


Leu Arg Asn Pro Asp Leu Ile Gln Ala Gly Tyr Tyr Ser Phe Gly Leu 
545                 550                 555                 560 


Ala Asn Glu Lys Arg Ala Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg 
                565                 570                 575     


Met Ser Pro Asp Ile Lys Gln Glu Leu Leu Arg Cys Asp Ile Ser Cys 
            580                 585                 590         


Lys Gly Gly His Ser Thr Val Thr Asp Leu Gln Glu Leu Leu Gly Cys 
        595                 600                 605             


Leu Tyr Glu Ser Gln Glu Glu Glu Leu Val Lys Glu Val Met Ala Gln 
    610                 615                 620                 


Phe Lys Glu Ile Ser Leu His Leu Asn Ala Val Asp Val Val Pro Ser 
625                 630                 635                 640 


Ser Phe Cys Val Lys His Cys Arg Asn Leu Gln Lys Met Ser Leu Gln 
                645                 650                 655     


Val Ile Lys Glu Asn Leu Pro Glu Asn Val Thr Ala Ser Glu Ser Asp 
            660                 665                 670         


Ala Glu Val Glu Arg Ser Gln Asp Asp Gln His Met Leu Pro Phe Trp 
        675                 680                 685             


Thr Asp Leu Cys Ser Ile Phe Gly Ser Asn Lys Asp Leu Met Gly Leu 
    690                 695                 700                 


Ala Ile Asn Asp Ser Phe Leu Ser Ala Ser Leu Val Arg Ile Leu Cys 
705                 710                 715                 720 


Glu Gln Ile Ala Ser Asp Thr Cys His Leu Gln Arg Val Val Phe Lys 
                725                 730                 735     


Asn Ile Ser Pro Ala Asp Ala His Arg Asn Leu Cys Leu Ala Leu Arg 
            740                 745                 750         


Gly His Lys Thr Val Thr Tyr Leu Thr Leu Gln Gly Asn Asp Gln Asp 
        755                 760                 765             


Asp Met Phe Pro Ala Leu Cys Glu Val Leu Arg His Pro Glu Cys Asn 
    770                 775                 780                 


Leu Arg Tyr Leu Gly Leu Val Ser Cys Ser Ala Thr Thr Gln Gln Trp 
785                 790                 795                 800 


Ala Asp Leu Ser Leu Ala Leu Glu Val Asn Gln Ser Leu Thr Cys Val 
                805                 810                 815     


Asn Leu Ser Asp Asn Glu Leu Leu Asp Glu Gly Ala Lys Leu Leu Tyr 
            820                 825                 830         


Thr Thr Leu Arg His Pro Lys Cys Phe Leu Gln Arg Leu Ser Leu Glu 
        835                 840                 845             


Asn Cys His Leu Thr Glu Ala Asn Cys Lys Asp Leu Ala Ala Val Leu 
    850                 855                 860                 


Val Val Ser Arg Glu Leu Thr His Leu Cys Leu Ala Lys Asn Pro Ile 
865                 870                 875                 880 


Gly Asn Thr Gly Val Lys Phe Leu Cys Glu Gly Leu Arg Tyr Pro Glu 
                885                 890                 895     


Cys Lys Leu Gln Thr Leu Val Leu Trp Asn Cys Asp Ile Thr Ser Asp 
            900                 905                 910         


Gly Cys Cys Asp Leu Thr Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu 
        915                 920                 925             


Cys Leu Asp Leu Gly Leu Asn His Ile Gly Val Lys Gly Met Lys Phe 
    930                 935                 940                 


Leu Cys Glu Ala Leu Arg Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp 
945                 950                 955                 960 


Leu Trp Gly Cys Ser Ile Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser 
                965                 970                 975     


Ala Leu Ser Cys Asn Gln Ser Leu Val Thr Leu Asp Leu Gly Gln Asn 
            980                 985                 990         


Pro Leu Gly Ser Ser Gly Val Lys  Met Leu Phe Glu Thr  Leu Thr Cys 
        995                 1000                 1005             


Ser Ser  Gly Thr Leu Arg Thr  Leu Arg Leu Lys Ile  Asp Asp Phe 
    1010                 1015                 1020             


Asn Asp  Glu Leu Asn Lys Leu  Leu Glu Glu Ile Glu  Glu Lys Asn 
    1025                 1030                 1035             


Pro Gln  Leu Ile Ile Asp Thr  Glu Lys His His Pro  Trp Ala Glu 
    1040                 1045                 1050             


Arg Pro  Ser Ser His Asp Phe  Met Ile 
    1055                 1060         


<210> 7984
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7984
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 7985
<211> 171
<212> PRT
<213> Homo sapiens

<400> 7985
Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu 
            20                  25                  30          


Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser Arg 
        35                  40                  45              


Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn 
    50                  55                  60                  


Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala Pro 
65                  70                  75                  80  


Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val Ile 
                85                  90                  95      


Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser 
            100                 105                 110         


Phe Asn Gly Gln Gln Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln 
        115                 120                 125             


Thr Ile Pro Pro Pro Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg 
    130                 135                 140                 


Pro Pro Cys Gln Pro Gln Phe Ser Leu Thr Glu Pro Met Lys Val Gly 
145                 150                 155                 160 


Glu Ala Trp Glu Arg Glu Gly Cys Leu Gln Pro 
                165                 170     


<210> 7986
<211> 481
<212> PRT
<213> Homo sapiens

<400> 7986
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 7987
<211> 661
<212> PRT
<213> Homo sapiens

<400> 7987
Met Asn Thr Gly Arg Asp Ser Gln Ser Pro Asp Ser Ala Trp Arg Ser 
1               5                   10                  15      


Tyr Asn Asp Gly Asn Gln Glu Thr Leu Asn Gly Asp Ala Thr Tyr Ser 
            20                  25                  30          


Ser Leu Ala Ala Lys Gly Phe Arg Ser Val Arg Pro Asn Leu Gln Asp 
        35                  40                  45              


Lys Arg Ser Pro Thr Gln Ser Gln Ile Thr Val Asn Gly Asn Ser Gly 
    50                  55                  60                  


Gly Ala Val Ser Pro Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser 
65                  70                  75                  80  


Ala Tyr Ser Leu Pro Ala Ser Leu Asn Ser Ser Ile Val Met Gln His 
                85                  90                  95      


Gly Thr Ser Leu Asp Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser 
            100                 105                 110         


Leu Asp Gly Thr Thr Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu 
        115                 120                 125             


Glu Glu Lys Arg Val Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile 
    130                 135                 140                 


Gly Pro Val Asp Glu Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val 
145                 150                 155                 160 


Asp Arg Pro Lys Asp Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met 
                165                 170                 175     


Val His Lys Pro Asp Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr 
            180                 185                 190         


Tyr Asn Ala Gly Leu Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro 
        195                 200                 205             


Ala Ala Lys Thr Gln Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp 
    210                 215                 220                 


Asn Ser Pro Asn Ala Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro 
225                 230                 235                 240 


His Val Pro Pro Pro Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser 
                245                 250                 255     


Thr Glu Lys His Asp Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg 
            260                 265                 270         


Lys Phe Arg Ser Glu Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys 
        275                 280                 285             


Ser Ser Ile Leu Gln His Glu Arg Pro Pro Pro Lys Lys Pro Leu Asp 
    290                 295                 300                 


Tyr Val Gln Asp His Ser Ser Gly Val Phe Asn Glu Ala Ser Leu Tyr 
305                 310                 315                 320 


Gln Ser Ser Ile Asp Arg Ser Leu Glu Arg Pro Met Ser Ser Ala Ser 
                325                 330                 335     


Met Ala Ser Asp Phe Arg Lys Arg Arg Lys Ser Glu Pro Ala Val Gly 
            340                 345                 350         


Pro Pro Arg Gly Leu Gly Asp Gln Ser Ala Ser Arg Thr Ser Pro Gly 
        355                 360                 365             


Arg Val Asp Leu Pro Gly Ser Ser Thr Thr Leu Thr Lys Ser Phe Thr 
    370                 375                 380                 


Ser Ser Ser Pro Ser Ser Pro Ser Arg Ala Lys Asp Arg Glu Ser Pro 
385                 390                 395                 400 


Arg Ser Tyr Ser Ser Thr Leu Thr Asp Met Gly Arg Ser Ala Pro Arg 
                405                 410                 415     


Glu Arg Arg Gly Thr Pro Glu Lys Glu Lys Leu Pro Ala Lys Ala Val 
            420                 425                 430         


Tyr Asp Phe Lys Ala Gln Thr Ser Lys Glu Leu Ser Phe Lys Lys Gly 
        435                 440                 445             


Asp Thr Val Tyr Ile Leu Arg Lys Ile Asp Gln Asn Trp Tyr Glu Gly 
    450                 455                 460                 


Glu His His Gly Arg Val Gly Ile Phe Pro Ile Ser Tyr Val Glu Lys 
465                 470                 475                 480 


Leu Thr Pro Pro Glu Lys Ala Gln Pro Ala Arg Pro Pro Pro Pro Ala 
                485                 490                 495     


Gln Pro Gly Glu Ile Gly Glu Ala Ile Ala Lys Tyr Asn Phe Asn Ala 
            500                 505                 510         


Asp Thr Asn Val Glu Leu Ser Leu Arg Lys Gly Asp Arg Val Ile Leu 
        515                 520                 525             


Leu Lys Arg Val Asp Gln Asn Trp Tyr Glu Gly Lys Ile Pro Gly Thr 
    530                 535                 540                 


Asn Arg Gln Gly Ile Phe Pro Val Ser Tyr Val Glu Val Val Lys Lys 
545                 550                 555                 560 


Asn Thr Lys Gly Ala Glu Asp Tyr Pro Asp Pro Pro Ile Pro His Ser 
                565                 570                 575     


Tyr Ser Ser Asp Arg Ile His Ser Leu Ser Ser Asn Lys Pro Gln Arg 
            580                 585                 590         


Pro Val Phe Thr His Glu Asn Ile Gln Gly Gly Gly Glu Pro Phe Gln 
        595                 600                 605             


Ala Leu Tyr Asn Tyr Thr Pro Arg Asn Glu Asp Glu Leu Glu Leu Arg 
    610                 615                 620                 


Glu Ser Asp Val Ile Asp Val Met Glu Lys Cys Asp Asp Gly Trp Phe 
625                 630                 635                 640 


Val Gly Thr Ser Arg Arg Thr Lys Phe Phe Gly Thr Phe Pro Gly Asn 
                645                 650                 655     


Tyr Val Lys Arg Leu 
            660     


<210> 7988
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7988
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 7989
<211> 238
<212> PRT
<213> Homo sapiens

<400> 7989
Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe 
1               5                   10                  15      


Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser 
            20                  25                  30          


Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu 
        35                  40                  45              


Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr 
    50                  55                  60                  


Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg 
65                  70                  75                  80  


Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly 
            100                 105                 110         


Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln 
        115                 120                 125             


Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu Thr Leu Ser 
    130                 135                 140                 


Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val Gly Ser Val 
145                 150                 155                 160 


Ile Thr Lys Lys Leu Glu Asp Val Asn Ile Arg Ser Ile Gln His Ser 
                165                 170                 175     


Ile Ser Met Pro Ala Met Arg Asn Ser Pro Thr Phe Lys Ser Phe Glu 
            180                 185                 190         


Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys Pro Ala 
        195                 200                 205             


Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala Ser Ala 
    210                 215                 220                 


Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu 
225                 230                 235             


<210> 7990
<211> 35
<212> PRT
<213> Homo sapiens

<400> 7990
Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg 
        35  


<210> 7991
<211> 108
<212> PRT
<213> Homo sapiens

<400> 7991
Met Thr Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Gln Ser Asp Ser Val Lys Gly Lys Arg Arg Asp Asp Gly Leu Ser 
            20                  25                  30          


Ala Ala Ala Arg Lys Gln Ser Ala Ile Thr Ser Ser Arg Asn Phe Leu 
        35                  40                  45              


Tyr Pro Ala Tyr Val Tyr Phe Pro Ser Ser Val Pro Ser Pro Pro Arg 
    50                  55                  60                  


Lys Tyr Thr Gln Thr Tyr Tyr Ala Ala Val Pro Ala Gly Trp Trp Gly 
65                  70                  75                  80  


Ser Gly Gly Gly Pro Ala Thr Gln Pro Ala Ala Gly Gly Arg Trp Arg 
                85                  90                  95      


Phe Leu His Ile Leu Gly Thr Gln Pro Gln Ser His 
            100                 105             


<210> 7992
<211> 281
<212> PRT
<213> Homo sapiens

<400> 7992
Met Gly Ala Gly Asn Leu Pro Pro Ile Thr Gln Glu Glu Ala Leu His 
1               5                   10                  15      


Ile Leu Gly Phe Gln Pro Pro Phe Glu Asp Ile Arg Phe Gly Pro Phe 
            20                  25                  30          


Thr Gly Asn Thr Thr Leu Met Arg Trp Phe Arg Gln Ile Asn Asp His 
        35                  40                  45              


Phe His Val Lys Gly Cys Ser Tyr Val Leu Tyr Lys Pro His Gly Lys 
    50                  55                  60                  


Asn Lys Thr Ala Gly Glu Thr Ala Ser Gly Ala Leu Ser Lys Leu Thr 
65                  70                  75                  80  


Arg Gly Leu Lys Asp Glu Ser Leu Ala Tyr Ile Tyr His Cys Gln Asn 
                85                  90                  95      


His Tyr Phe Cys Pro Ile Gly Phe Glu Ala Thr Pro Val Lys Ala Asn 
            100                 105                 110         


Lys Ala Phe Ser Arg Gly Pro Leu Ser Pro Gln Glu Val Glu Tyr Trp 
        115                 120                 125             


Ile Leu Ile Gly Glu Ser Ser Arg Lys His Pro Ala Ile His Cys Lys 
    130                 135                 140                 


Lys Trp Ala Asp Ile Val Thr Asp Leu Asn Thr Gln Asn Pro Glu Tyr 
145                 150                 155                 160 


Leu Asp Ile Arg His Leu Glu Arg Gly Leu Gln Tyr Arg Lys Thr Lys 
                165                 170                 175     


Lys Pro Thr Phe Phe Ser Ser Gln Val Gly Gly Asn Leu His Cys Ile 
            180                 185                 190         


Ile Ala Phe Gln Arg Leu Asn Trp Gln Arg Phe Gly Leu Trp Asn Phe 
        195                 200                 205             


Pro Phe Gly Thr Ile Arg Gln Glu Ser Gln Pro Pro Thr His Ala Gln 
    210                 215                 220                 


Gly Ile Ala Lys Ser Glu Ser Glu Asp Asn Ile Ser Lys Lys Gln His 
225                 230                 235                 240 


Gly Arg Leu Gly Arg Ser Phe Ser Ala Ser Phe His Gln Asp Ser Ala 
                245                 250                 255     


Trp Lys Lys Met Ser Ser Ile His Glu Arg Arg Asn Ser Gly Tyr Gln 
            260                 265                 270         


Gly Tyr Ser Asp Tyr Asp Gly Asn Asp 
        275                 280     


<210> 7993
<211> 70
<212> PRT
<213> Homo sapiens

<400> 7993
Met Arg Ala Leu Thr Val Gln Arg Val Lys Phe Ala Met Asp Leu Pro 
1               5                   10                  15      


Leu Leu Lys Arg Ala Gly Gln Asp Leu Ala Glu Lys Thr Lys Asn Phe 
            20                  25                  30          


Val Ser Arg Ser Leu Val Ile Gly Glu Val Leu Ser Met Ala Asp Met 
        35                  40                  45              


Ala Thr Gly Val Lys Cys Gly Ile Ile Tyr Trp Leu Phe Gly Gly Ala 
    50                  55                  60                  


Ile Arg Asn Leu Gly Ser 
65                  70  


<210> 7994
<211> 547
<212> PRT
<213> Homo sapiens

<400> 7994
Met Ala Gly Thr Lys Asn Lys Thr Arg Ala Gln Ala Lys Thr Glu Lys 
1               5                   10                  15      


Lys Ala Ala Ile Gln Ala Lys Ala Gly Ala Glu Arg Glu Ala Thr Gly 
            20                  25                  30          


Val Val Arg Pro Val Ala Lys Thr Arg Ala Lys Ala Lys Ala Lys Thr 
        35                  40                  45              


Gly Ser Lys Thr Asp Ala Val Ala Glu Met Lys Ala Val Ser Lys Asn 
    50                  55                  60                  


Lys Val Val Ala Glu Thr Lys Glu Gly Ala Leu Ser Glu Pro Lys Thr 
65                  70                  75                  80  


Leu Gly Lys Ala Met Gly Asp Phe Thr Pro Lys Ala Gly Asn Glu Ser 
                85                  90                  95      


Thr Ser Ser Thr Cys Lys Asn Glu Ala Gly Thr Asp Ala Trp Phe Trp 
            100                 105                 110         


Ala Gly Glu Glu Ala Thr Ile Asn Ser Trp Phe Trp Asn Gly Glu Glu 
        115                 120                 125             


Ala Gly Asn Ser Phe Ser Thr Lys Asn Asp Lys Pro Glu Ile Gly Ala 
    130                 135                 140                 


Gln Val Cys Ala Glu Glu Leu Glu Pro Ala Ala Gly Ala Asp Cys Lys 
145                 150                 155                 160 


Pro Arg Ser Gly Ala Glu Glu Glu Glu Glu Glu Asn Val Ile Gly Asn 
                165                 170                 175     


Trp Phe Trp Glu Gly Asp Asp Thr Ser Phe Asp Pro Asn Pro Lys Pro 
            180                 185                 190         


Val Ser Arg Ile Val Lys Pro Gln Pro Val Tyr Glu Ile Asn Glu Lys 
        195                 200                 205             


Asn Arg Pro Lys Asp Trp Ser Glu Val Thr Ile Trp Pro Asn Ala Pro 
    210                 215                 220                 


Ala Val Thr Pro Ala Val Leu Gly Phe Arg Ser Gln Ala Pro Ser Glu 
225                 230                 235                 240 


Ala Ser Pro Pro Ser Tyr Ile Val Leu Ala Ser Ala Glu Glu Asn Ala 
                245                 250                 255     


Cys Ser Leu Pro Val Ala Thr Ala Cys Arg Pro Ser Arg Asn Thr Arg 
            260                 265                 270         


Ser Cys Ser Gln Pro Ile Pro Glu Cys Arg Phe Asp Ser Asp Pro Cys 
        275                 280                 285             


Ile Gln Thr Ile Asp Glu Ile Arg Arg Gln Ile Arg Ile Arg Glu Val 
    290                 295                 300                 


Asn Gly Ile Lys Pro Phe Ala Cys Pro Cys Lys Met Glu Cys Tyr Met 
305                 310                 315                 320 


Asp Ser Glu Glu Phe Glu Lys Leu Val Ser Leu Leu Lys Ser Thr Thr 
                325                 330                 335     


Asp Pro Leu Ile His Lys Ile Ala Arg Ile Ala Met Gly Val His Asn 
            340                 345                 350         


Val His Pro Phe Ala Gln Glu Phe Ile Asn Glu Val Gly Val Val Thr 
        355                 360                 365             


Leu Ile Glu Ser Leu Leu Ser Phe Pro Ser Pro Glu Met Arg Lys Lys 
    370                 375                 380                 


Thr Val Ile Thr Leu Asn Pro Pro Ser Gly Asp Glu Arg Gln Arg Lys 
385                 390                 395                 400 


Ile Glu Leu His Val Lys His Met Cys Lys Glu Thr Met Ser Phe Pro 
                405                 410                 415     


Leu Asn Ser Pro Gly Gln Gln Ser Gly Leu Lys Ile Leu Gly Gln Leu 
            420                 425                 430         


Thr Thr Asp Phe Val His His Tyr Ile Val Ala Asn Tyr Phe Ser Glu 
        435                 440                 445             


Leu Phe His Leu Leu Ser Ser Gly Asn Cys Lys Thr Arg Asn Leu Val 
    450                 455                 460                 


Leu Lys Leu Leu Leu Asn Met Ser Glu Asn Pro Thr Ala Ala Arg Asp 
465                 470                 475                 480 


Met Ile Asn Met Lys Ala Leu Ala Ala Leu Lys Leu Ile Phe Asn Gln 
                485                 490                 495     


Lys Glu Ala Lys Ala Asn Leu Val Ser Gly Val Ala Ile Phe Ile Asn 
            500                 505                 510         


Ile Lys Glu His Ile Arg Lys Gly Ser Ile Val Val Val Asp His Leu 
        515                 520                 525             


Ser Tyr Asn Thr Leu Met Ala Ile Phe Arg Glu Val Lys Glu Ile Ile 
    530                 535                 540                 


Glu Thr Met 
545         


<210> 7995
<211> 162
<212> PRT
<213> Homo sapiens

<400> 7995
Met Ser Tyr Asn Cys Cys Ser Arg Asn Phe Ser Ser Cys Ser His Gly 
1               5                   10                  15      


Gly Tyr Leu His Tyr Pro Gly Ser Ser Cys Gly Ser Ser Tyr Pro Ser 
            20                  25                  30          


Asn Leu Val Tyr Ser Thr Asp Leu Cys Ser Pro Ser Thr Cys Gln Leu 
        35                  40                  45              


Gly Ser Ser Leu Tyr Arg Gly Cys Gln Glu Thr Cys Trp Arg Pro Asn 
    50                  55                  60                  


Ser Cys Gln Thr Phe Cys Tyr Tyr Pro Arg Thr His Met Leu Cys Asn 
65                  70                  75                  80  


Ser Cys Leu Thr Met His Val Gly Ser Arg Gly Phe Gly Ser Asn Ser 
                85                  90                  95      


Cys Cys Ser Leu Ser Cys Gly Ser Arg Ser Cys Ser Ser Leu Gly Cys 
            100                 105                 110         


Gly Ser Asn Gly Phe Arg Tyr Leu Asn Tyr Arg Ile His Thr Ser Pro 
        115                 120                 125             


Ser Gln Ser Tyr Arg Ser Arg Phe Cys His Pro Ile Tyr Phe Pro Pro 
    130                 135                 140                 


Arg Arg Trp Phe His Ser Ser Cys Tyr Gln Pro Phe Cys Arg Ser Gly 
145                 150                 155                 160 


Phe Tyr 
        


<210> 7996
<211> 164
<212> PRT
<213> Homo sapiens

<400> 7996
Met Phe Ile Ser Phe Tyr Asp Phe Lys Asn Ile Pro Gln Asp Ser Arg 
1               5                   10                  15      


Cys Asp Gly Gln Leu Phe Ile Asn Gly Arg Asn Asn Lys Asn Asn Ser 
            20                  25                  30          


Ile Ser Leu Tyr Phe Gln Gly Gly Leu Arg His Ala Ser Ala Ser Ile 
        35                  40                  45              


Gly Gly Ser Glu Ala Tyr Arg His Met Lys Phe Glu Gly Gly Val His 
    50                  55                  60                  


Arg Val Gln Arg Val Pro Lys Thr Glu Lys Gln Gly Arg Val His Thr 
65                  70                  75                  80  


Ser Thr Met Thr Val Ala Ile Leu Pro Gln Pro Thr Glu Ile Asn Leu 
                85                  90                  95      


Val Ile Asn Pro Lys Asp Leu Arg Ile Asp Thr Lys Arg Ala Ser Gly 
            100                 105                 110         


Ala Gly Gly Gln His Val Asn Thr Thr Asp Ser Ala Val Arg Ile Val 
        115                 120                 125             


His Leu Pro Thr Gly Val Val Ser Glu Cys Gln Gln Glu Arg Ser Gln 
    130                 135                 140                 


Leu Lys Asn Lys Glu Leu Ala Met Thr Lys Leu Arg Ala Lys Leu Tyr 
145                 150                 155                 160 


Ser Met His Leu 
                


<210> 7997
<211> 721
<212> PRT
<213> Homo sapiens

<400> 7997
Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe Arg Glu 
1               5                   10                  15      


Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys Ala Arg 
            20                  25                  30          


Thr Ile Ala Val Gln Thr Pro Asp Gly Gly Ser Ala Ala Gly Gly Leu 
        35                  40                  45              


Gly Gly Gly Ala Gly Gly Gly Gly Asp His Ala Asp Lys Leu Ser Leu 
    50                  55                  60                  


Tyr Ser Glu Thr Asp Ser Gly Tyr Gly Ser Tyr Thr Pro Ser Leu Lys 
65                  70                  75                  80  


Ser Pro Asn Gly Val Arg Val Leu Pro Met Val Pro Ala Pro Pro Gly 
                85                  90                  95      


Ser Ser Ala Ala Ala Ala Arg Gly Ala Ala Cys Ser Ser Leu Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Ile Thr Cys Pro Gln Cys His Arg Ser Ala Ser Leu 
        115                 120                 125             


Asp His Arg Gly Leu Arg Gly Phe Gln Arg Asn Arg Leu Leu Glu Ala 
    130                 135                 140                 


Ile Val Gln Arg Tyr Gln Gln Gly Arg Gly Ala Val Pro Gly Thr Ser 
145                 150                 155                 160 


Ala Ala Ala Ala Val Ala Ile Cys Gln Leu Cys Asp Arg Thr Pro Pro 
                165                 170                 175     


Glu Pro Ala Ala Thr Leu Cys Glu Gln Cys Asp Val Leu Tyr Cys Ser 
            180                 185                 190         


Ala Cys Gln Leu Lys Cys His Pro Ser Arg Gly Pro Phe Ala Lys His 
        195                 200                 205             


Arg Leu Gly Ala Pro Ser Gly Gly Gly Gly Cys Lys Ser Pro Gly Gly 
    210                 215                 220                 


Ala Gly Ala Gly Ala Thr Gly Gly Ser Thr Ala Arg Lys Phe Pro Thr 
225                 230                 235                 240 


Cys Pro Glu His Glu Met Glu Asn Tyr Ser Met Tyr Cys Val Ser Cys 
                245                 250                 255     


Arg Thr Pro Val Cys Tyr Leu Cys Leu Glu Glu Gly Arg His Ala Lys 
            260                 265                 270         


His Glu Val Lys Pro Leu Gly Ala Met Trp Lys Gln His Lys Ala Gln 
        275                 280                 285             


Leu Ser Gln Ala Leu Asn Gly Val Ser Asp Lys Ala Lys Glu Ala Lys 
    290                 295                 300                 


Glu Phe Leu Val Gln Leu Lys Asn Ile Leu Gln Gln Ile Gln Glu Asn 
305                 310                 315                 320 


Gly Leu Asp Tyr Glu Ala Cys Leu Val Ala Gln Cys Asp Ala Leu Val 
                325                 330                 335     


Asp Ala Leu Thr Arg Gln Lys Ala Lys Leu Leu Thr Lys Val Thr Lys 
            340                 345                 350         


Glu Arg Glu His Lys Leu Lys Met Val Trp Asp Gln Ile Asn His Cys 
        355                 360                 365             


Thr Leu Lys Leu Arg Gln Ser Thr Gly Leu Met Glu Tyr Cys Leu Glu 
    370                 375                 380                 


Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln Ile Ser Asp Ala 
385                 390                 395                 400 


Leu Ile Lys Arg Val Gln Val Ser Gln Glu Gln Trp Val Lys Gly Ala 
                405                 410                 415     


Leu Glu Pro Lys Val Ser Ala Glu Phe Asp Leu Thr Leu Asp Ser Glu 
            420                 425                 430         


Pro Leu Leu Gln Ala Ile His Gln Leu Asp Phe Ile Gln Met Lys Cys 
        435                 440                 445             


Arg Val Pro Pro Val Pro Leu Leu Gln Leu Glu Lys Cys Cys Thr Arg 
    450                 455                 460                 


Asn Asn Ser Val Thr Leu Ala Trp Arg Met Pro Pro Phe Thr His Ser 
465                 470                 475                 480 


Pro Val Asp Gly Tyr Ile Leu Glu Leu Asp Asp Gly Ala Gly Gly Gln 
                485                 490                 495     


Phe Arg Glu Val Tyr Val Gly Lys Glu Thr Leu Cys Thr Ile Asp Gly 
            500                 505                 510         


Leu His Phe Asn Ser Thr Tyr Asn Ala Arg Val Lys Ala Phe Asn Ser 
        515                 520                 525             


Ser Gly Val Gly Pro Tyr Ser Lys Thr Val Val Leu Gln Thr Ser Asp 
    530                 535                 540                 


Val Ala Trp Phe Thr Phe Asp Pro Asn Ser Gly His Arg Asp Ile Ile 
545                 550                 555                 560 


Leu Ser Asn Asp Asn Gln Thr Ala Thr Cys Ser Ser Tyr Asp Asp Arg 
                565                 570                 575     


Val Val Leu Gly Thr Ala Ala Phe Ser Lys Gly Val His Tyr Trp Glu 
            580                 585                 590         


Leu His Val Asp Arg Tyr Asp Asn His Pro Asp Pro Ala Phe Gly Val 
        595                 600                 605             


Ala Arg Ala Ser Val Val Lys Asp Met Met Leu Gly Lys Asp Asp Lys 
    610                 615                 620                 


Ala Trp Ala Met Tyr Val Asp Asn Asn Arg Ser Trp Phe Met His Cys 
625                 630                 635                 640 


Asn Ser His Thr Asn Arg Thr Glu Gly Gly Val Cys Lys Gly Ala Thr 
                645                 650                 655     


Val Gly Val Leu Leu Asp Leu Asn Lys His Thr Leu Thr Phe Phe Ile 
            660                 665                 670         


Asn Gly Gln Gln Gln Gly Pro Thr Ala Phe Ser His Val Asp Gly Val 
        675                 680                 685             


Phe Met Pro Ala Leu Ser Leu Asn Arg Asn Val Gln Val Thr Leu His 
    690                 695                 700                 


Thr Gly Leu Glu Val Pro Thr Asn Leu Gly Arg Pro Lys Leu Ser Gly 
705                 710                 715                 720 


Asn 
    


<210> 7998
<211> 492
<212> PRT
<213> Homo sapiens

<400> 7998
Met Asp Phe Leu Leu Gly Asn Pro Phe Ser Ser Pro Val Gly Gln Arg 
1               5                   10                  15      


Ile Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Ala Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe 
    50                  55                  60                  


His Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn 
65                  70                  75                  80  


Cys Gly His Arg Phe His Val Leu Val Ala Ser Gln Asp Phe Val Glu 
                85                  90                  95      


Ser Val Leu Val Arg Thr Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile 
            100                 105                 110         


Val His Asp Lys Val Leu Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe 
        115                 120                 125             


Arg Ser Ser Pro Asp Leu Thr Gly Val Val Thr Ile Tyr Glu Asp Leu 
    130                 135                 140                 


Arg Arg Lys Gly Leu Glu Phe Pro Met Thr Asp Leu Asp Met Leu Ser 
145                 150                 155                 160 


Pro Ile His Thr Pro Gln Arg Thr Val Phe Asn Ser Glu Thr Gln Ser 
                165                 170                 175     


Gly Gln Asp Ser Val Gly Thr Asp Ser Ser Gln Gln Glu Asp Ser Gly 
            180                 185                 190         


Gln His Ala Ala Pro Leu Pro Ala Pro Pro Ile Leu Ser Gly Asp Thr 
        195                 200                 205             


Pro Ile Ala Pro Thr Pro Glu Gln Ile Gly Lys Leu Arg Ser Glu Leu 
    210                 215                 220                 


Glu Met Val Ser Gly Asn Val Arg Val Met Ser Glu Met Leu Thr Glu 
225                 230                 235                 240 


Leu Val Pro Thr Gln Ala Glu Pro Ala Asp Leu Glu Leu Leu Gln Glu 
                245                 250                 255     


Leu Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Val Leu Glu Leu Ile 
            260                 265                 270         


Pro Gln Ile Ala Asn Glu Gln Leu Thr Glu Glu Leu Leu Ile Val Asn 
        275                 280                 285             


Asp Asn Leu Asn Asn Val Phe Leu Arg His Glu Arg Phe Glu Arg Phe 
    290                 295                 300                 


Arg Thr Gly Gln Thr Thr Lys Ala Pro Ser Glu Ala Glu Pro Ala Ala 
305                 310                 315                 320 


Asp Leu Ile Asp Met Gly Pro Asp Pro Ala Ala Thr Gly Asn Leu Ser 
                325                 330                 335     


Ser Gln Leu Ala Gly Met Asn Leu Gly Ser Ser Ser Val Arg Ala Gly 
            340                 345                 350         


Leu Gln Ser Leu Glu Ala Ser Gly Arg Leu Glu Asp Glu Phe Asp Met 
        355                 360                 365             


Phe Ala Leu Thr Arg Gly Ser Ser Leu Ala Asp Gln Arg Lys Glu Val 
    370                 375                 380                 


Lys Tyr Glu Ala Pro Gln Ala Thr Asp Gly Leu Ala Gly Ala Leu Asp 
385                 390                 395                 400 


Ala Arg Gln Gln Ser Thr Gly Ala Ile Pro Val Thr Gln Ala Cys Leu 
                405                 410                 415     


Met Glu Asp Ile Glu Gln Trp Leu Ser Thr Asp Val Gly Asn Asp Ala 
            420                 425                 430         


Glu Glu Pro Lys Gly Val Thr Ser Glu Glu Phe Asp Lys Phe Leu Glu 
        435                 440                 445             


Glu Arg Ala Lys Ala Ala Asp Arg Leu Pro Asn Leu Ser Ser Pro Ser 
    450                 455                 460                 


Ala Glu Gly Pro Pro Gly Pro Pro Ser Gly Pro Ala Pro Arg Lys Lys 
465                 470                 475                 480 


Thr Gln Glu Lys Asp Asp Asp Met Leu Phe Ala Leu 
                485                 490         


<210> 7999
<211> 248
<212> PRT
<213> Homo sapiens

<400> 7999
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln 
                245             


<210> 8000
<211> 6
<212> PRT
<213> Homo sapiens

<400> 8000
Met Ser Arg Arg Arg Phe 
1               5       


<210> 8001
<211> 54
<212> PRT
<213> Homo sapiens

<400> 8001
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg 
    50                  


<210> 8002
<211> 481
<212> PRT
<213> Homo sapiens

<400> 8002
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 8003
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8003
Met Gly Gln Gln Ser Ser Val Arg Arg Leu Lys Arg Ser Val Pro Cys 
1               5                   10                  15      


Glu Ser Asn Glu Ala Asn Glu Ala Asn Glu Ala Asn Lys Thr Met Pro 
            20                  25                  30          


Glu Thr Pro Thr Gly Asp Ser Asp Pro Gln Pro Ala Pro Lys Lys Met 
        35                  40                  45              


Lys Thr Ser Glu Ser Ser Thr Ile Leu Val Val Arg Tyr Arg Arg Asn 
    50                  55                  60                  


Val Lys Arg Thr Ser Pro Glu Glu Leu Val Asn Asp His Ala Arg Glu 
65                  70                  75                  80  


Asn Arg Ile Asn Pro Asp Gln Met Glu Glu Glu Glu Phe Ile Glu Ile 
                85                  90                  95      


Thr Thr Glu Arg Pro Lys Lys 
            100             


<210> 8004
<211> 972
<212> PRT
<213> Homo sapiens

<400> 8004
Met Glu Arg Met Asn Trp Leu Ser Arg Leu Ala Ser Arg Gly Pro Gly 
1               5                   10                  15      


His Arg Ile Pro Gln Gly Ala Asn Leu Gln Thr Pro Val Met Ala Asp 
            20                  25                  30          


Pro Glu Thr Cys Leu Met Val Phe Lys Asn His Trp Ser Gln Val Val 
        35                  40                  45              


Arg Ile Leu Glu Arg Gln Gly Pro Arg Ala Ala Pro Gly Gly Ala Asp 
    50                  55                  60                  


Asp Leu Ser Ala Val Arg Asn His Thr Tyr Gln Met Leu Thr Leu Leu 
65                  70                  75                  80  


Ala Glu Asp Arg Ala Val Pro Ser Ala Pro Thr Gly Pro Gly Pro Leu 
                85                  90                  95      


Leu Glu Phe Ala Leu His Glu Asp Leu Leu Thr Arg Val Leu Thr Trp 
            100                 105                 110         


Gln Leu Gln Trp Asp Glu Leu Gly Asp Gly Val Glu Glu Arg Arg Ala 
        115                 120                 125             


Glu Gln Leu Lys Leu Phe Glu Met Leu Val Ser Glu Ala Arg Gln Pro 
    130                 135                 140                 


Leu Leu Arg His Gly Pro Val Arg Glu Ala Leu Leu Thr Leu Leu Asp 
145                 150                 155                 160 


Ala Cys Gly Arg Pro Val Pro Ser Ser Pro Ala Leu Asp Glu Gly Leu 
                165                 170                 175     


Val Leu Leu Leu Ser Gln Leu Cys Val Cys Val Ala Gln Glu Pro Ser 
            180                 185                 190         


Leu Leu Glu Phe Phe Leu Gln Pro Pro Pro Glu Pro Gly Ala Ala Pro 
        195                 200                 205             


Arg Leu Leu Leu Phe Ser Arg Leu Val Pro Phe Val His Arg Glu Gly 
    210                 215                 220                 


Thr Leu Gly Gln Gln Ala Arg Asp Ala Leu Leu Leu Leu Met Ala Leu 
225                 230                 235                 240 


Ser Ala Gly Ser Pro Thr Val Gly Arg Tyr Ile Ala Asp His Ser Tyr 
                245                 250                 255     


Phe Cys Pro Val Leu Ala Thr Gly Leu Ser Ala Leu Tyr Ser Ser Leu 
            260                 265                 270         


Pro Arg Lys Ile Glu Val Pro Gly Asp Asp Trp His Cys Leu Arg Arg 
        275                 280                 285             


Glu Asp Trp Leu Gly Val Pro Ala Leu Ala Leu Phe Met Ser Ser Leu 
    290                 295                 300                 


Glu Phe Cys Asn Ala Val Ile Gln Val Ala His Pro Leu Val Gln Lys 
305                 310                 315                 320 


Gln Leu Val Asp Tyr Ile His Asn Gly Phe Leu Val Pro Val Met Gly 
                325                 330                 335     


Pro Ala Leu His Lys Thr Ser Val Glu Glu Met Ile Ala Ser Thr Ala 
            340                 345                 350         


Tyr Leu Glu Leu Phe Leu Arg Ser Ile Ser Glu Pro Ala Leu Leu Arg 
        355                 360                 365             


Thr Phe Leu Arg Phe Leu Leu Leu His Arg His Asp Thr His Thr Ile 
    370                 375                 380                 


Leu Asp Thr Leu Val Ala Arg Ile Gly Ser Asn Ser Arg Leu Cys Met 
385                 390                 395                 400 


Val Ser Leu Ser Leu Phe Arg Thr Leu Leu Asn Leu Ser Cys Glu Asp 
                405                 410                 415     


Val Leu Leu Gln Leu Val Leu Arg Tyr Leu Val Pro Cys Asn His Val 
            420                 425                 430         


Met Leu Ser Gln Lys Pro Ala Val Arg Asp Val Asp Leu Tyr Gly Arg 
        435                 440                 445             


Ala Ala Asp Lys Phe Leu Ser Leu Ile Pro Arg Cys Cys Arg His His 
    450                 455                 460                 


Ala Pro Ser Pro Pro Arg Pro Glu His Ala Ser Trp Ala Arg Gly Pro 
465                 470                 475                 480 


Gly Ser Pro Ser Val Asp Ser Ser Ser Val Thr Thr Val Pro Arg Pro 
                485                 490                 495     


Ser Thr Pro Ser Arg Leu Ala Leu Phe Leu Arg Gln Gln Ser Leu Gly 
            500                 505                 510         


Gly Ser Glu Ser Pro Gly Pro Ala Pro Cys Ser Pro Gly Leu Ser Ala 
        515                 520                 525             


Ser Pro Ala Ser Ser Pro Gly Arg Arg Pro Thr Pro Ala Glu Glu Pro 
    530                 535                 540                 


Gly Glu Leu Glu Asp Asn Tyr Leu Glu Tyr Leu Arg Glu Ala Arg Arg 
545                 550                 555                 560 


Gly Val Asp Arg Cys Val Arg Ala Cys Arg Thr Trp Ser Ala Pro Tyr 
                565                 570                 575     


Asp Gly Glu Arg Pro Ser Pro Glu Pro Ser Pro Phe Gly Ser Arg Thr 
            580                 585                 590         


Lys Lys Arg Ser Leu Leu Pro Glu Glu Asp Arg Asn Asn Val Gly Glu 
        595                 600                 605             


Gly Glu Glu Glu Glu Leu Gly Arg Arg Gly Arg Ala Gly Gly Ala Gly 
    610                 615                 620                 


Glu Gly Pro Gly His Leu Pro Pro Pro Gln Leu Asn Gly Val Pro Gly 
625                 630                 635                 640 


Ser Trp Pro Glu Gly Ala Lys Lys Val Arg Leu Val Pro Lys Glu Gly 
                645                 650                 655     


Ala Gly Glu Leu Leu Glu Gly Ile Ser Glu Gly Met Ala Gly Leu Glu 
            660                 665                 670         


Gly Phe Gly Gln Glu Leu Arg Glu Leu Glu Val Ala Leu Ser Asn Gly 
        675                 680                 685             


Gly Thr Gly Ser Glu Ser Pro Leu Glu Pro Pro Leu Pro Leu Glu Glu 
    690                 695                 700                 


Glu Glu Ala Tyr Glu Ser Phe Thr Cys Pro Pro Glu Pro Pro Gly Pro 
705                 710                 715                 720 


Phe Leu Ser Ser Pro Leu Arg Thr Leu Asn Gln Leu Pro Ser Gln Pro 
                725                 730                 735     


Phe Thr Gly Pro Phe Met Ala Val Leu Phe Ala Lys Leu Glu Asn Met 
            740                 745                 750         


Leu Gln Asn Ser Val Tyr Val Asn Phe Leu Leu Thr Gly Leu Val Ala 
        755                 760                 765             


Gln Leu Ala Cys His Pro Gln Pro Leu Leu Arg Ser Phe Leu Leu Asn 
    770                 775                 780                 


Thr Asn Met Val Phe Gln Pro Ser Val Lys Ser Leu Leu Gln Val Leu 
785                 790                 795                 800 


Gly Ser Val Lys Asn Lys Ile Glu Asn Phe Ala Ala Ser Gln Glu Asp 
                805                 810                 815     


Phe Pro Ala Leu Leu Ser Lys Ala Lys Lys Tyr Leu Ile Ala Arg Gly 
            820                 825                 830         


Lys Leu Asp Trp Ala Glu Gly Pro Ala Ala Gly Pro Ala Pro Arg Arg 
        835                 840                 845             


Ser Asp Pro Leu Val Lys Ser Arg Arg Pro Ser Leu Gly Glu Leu Leu 
    850                 855                 860                 


Leu Arg His Ala His Ser Pro Thr Arg Ala Arg Gln Ala Ala Gln Leu 
865                 870                 875                 880 


Val Leu Gln Pro Gly Arg Asp Gly Ala Gly Leu Gly Leu Ser Gly Gly 
                885                 890                 895     


Ser Pro Gly Ala Ser Thr Pro Val Leu Leu Thr Arg Gly Gly Ala Pro 
            900                 905                 910         


Glu Arg Gln Gly Glu Ala Leu Arg Val Lys Asn Ala Val Tyr Cys Ala 
        915                 920                 925             


Val Ile Phe Pro Glu Phe Leu Lys Glu Leu Ala Ala Ile Ser Gln Ala 
    930                 935                 940                 


His Ala Val Thr Ser Pro Phe Leu Leu Glu Thr Ser Glu Glu Gly Ser 
945                 950                 955                 960 


Gly Pro Leu Ile Ser Gly Cys Gly Pro Leu Asn Pro 
                965                 970         


<210> 8005
<211> 642
<212> PRT
<213> Homo sapiens

<400> 8005
Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr Gly Ser Val Glu 
1               5                   10                  15      


Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln Glu Ile Ala Arg 
            20                  25                  30          


Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg Val Phe Lys Pro 
        35                  40                  45              


Met Ala Asp Ala Ala Val Lys Ile Val Glu Lys Asn Gly Phe Ser Asp 
    50                  55                  60                  


Lys Ile Lys Val Ile Asn Lys His Ser Thr Glu Val Thr Val Gly Pro 
65                  70                  75                  80  


Glu Gly Asp Met Pro Cys Arg Ala Asn Ile Leu Val Thr Glu Leu Phe 
                85                  90                  95      


Asp Thr Glu Leu Ile Gly Glu Gly Ala Leu Pro Ser Tyr Glu His Ala 
            100                 105                 110         


His Arg His Leu Val Glu Glu Asn Cys Glu Ala Val Pro His Arg Ala 
        115                 120                 125             


Thr Val Tyr Ala Gln Leu Val Glu Ser Gly Arg Met Trp Ser Trp Asn 
    130                 135                 140                 


Lys Leu Phe Pro Ile His Val Gln Thr Ser Leu Gly Glu Gln Val Ile 
145                 150                 155                 160 


Val Pro Pro Val Asp Val Glu Ser Cys Pro Gly Ala Pro Ser Val Cys 
                165                 170                 175     


Asp Ile Gln Leu Asn Gln Val Ser Pro Ala Asp Phe Thr Val Leu Ser 
            180                 185                 190         


Asp Val Leu Pro Met Phe Ser Ile Asp Phe Ser Lys Gln Val Ser Ser 
        195                 200                 205             


Ser Ala Ala Cys His Ser Arg Arg Phe Glu Pro Leu Thr Ser Gly Arg 
    210                 215                 220                 


Ala Gln Val Val Leu Ser Trp Trp Asp Ile Glu Met Asp Pro Glu Gly 
225                 230                 235                 240 


Lys Ile Lys Cys Thr Met Ala Pro Phe Trp Ala His Ser Asp Pro Glu 
                245                 250                 255     


Glu Met Gln Trp Arg Asp His Trp Met Gln Cys Val Tyr Phe Leu Pro 
            260                 265                 270         


Gln Glu Glu Pro Val Val Gln Gly Ser Ala Leu Tyr Leu Val Ala His 
        275                 280                 285             


His Asp Asp Tyr Cys Val Trp Tyr Ser Leu Gln Arg Thr Ser Pro Glu 
    290                 295                 300                 


Lys Asn Glu Arg Val Arg Gln Met Arg Pro Val Cys Asp Cys Gln Ala 
305                 310                 315                 320 


His Leu Leu Trp Asn Arg Pro Arg Phe Gly Glu Ile Asn Asp Gln Asp 
                325                 330                 335     


Arg Thr Asp Arg Tyr Val Gln Ala Leu Arg Thr Val Leu Lys Pro Asp 
            340                 345                 350         


Ser Val Cys Leu Cys Val Ser Asp Gly Ser Leu Leu Ser Val Leu Ala 
        355                 360                 365             


His His Leu Gly Val Glu Gln Val Phe Thr Val Glu Ser Ser Ala Ala 
    370                 375                 380                 


Ser His Lys Leu Leu Arg Lys Ile Phe Lys Ala Asn His Leu Glu Asp 
385                 390                 395                 400 


Lys Ile Asn Ile Ile Glu Lys Arg Pro Glu Leu Leu Thr Asn Glu Asp 
                405                 410                 415     


Leu Gln Gly Arg Lys Val Ser Leu Leu Leu Gly Glu Pro Phe Phe Thr 
            420                 425                 430         


Thr Ser Leu Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val Arg Thr 
        435                 440                 445             


Ala Val Asp Gln His Leu Gly Pro Gly Ala Met Val Met Pro Gln Ala 
    450                 455                 460                 


Ala Ser Leu His Ala Val Val Val Glu Phe Arg Asp Leu Trp Arg Ile 
465                 470                 475                 480 


Arg Ser Pro Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile Met Asp 
                485                 490                 495     


Asp Met Ile Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu Ala Glu 
            500                 505                 510         


Pro His Pro Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu Pro Trp 
        515                 520                 525             


Gln Ile Leu Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln Pro Leu 
    530                 535                 540                 


Cys Ala Glu Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser His Ala 
545                 550                 555                 560 


Ala Val Leu Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr Leu Ser 
                565                 570                 575     


Thr Gly Leu Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys Trp Asn 
            580                 585                 590         


Pro His Cys Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro Asp Pro 
        595                 600                 605             


Arg Ala Leu Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val Glu Phe 
    610                 615                 620                 


His Pro Asp Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala Asp Thr 
625                 630                 635                 640 


Pro Asp 
        


<210> 8006
<211> 644
<212> PRT
<213> Homo sapiens

<400> 8006
Met Ser Val Thr Leu Thr Ser Val Lys Arg Val Gln Ser Ser Pro Asn 
1               5                   10                  15      


Leu Leu Ala Ala Gly Arg Asp Ser Gln Ser Pro Asp Ser Ala Trp Arg 
            20                  25                  30          


Ser Tyr Asn Asp Gly Asn Gln Glu Thr Leu Asn Gly Asp Ala Thr Tyr 
        35                  40                  45              


Ser Ser Leu Ala Ala Lys Gly Phe Arg Ser Val Arg Pro Asn Leu Gln 
    50                  55                  60                  


Asp Lys Arg Ser Pro Thr Gln Ser Gln Ile Thr Val Asn Gly Asn Ser 
65                  70                  75                  80  


Gly Gly Ala Val Ser Pro Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro 
                85                  90                  95      


Ser Ala Tyr Ser Leu Pro Ala Ser Leu Asn Ser Ser Ile Val Met Gln 
            100                 105                 110         


His Gly Thr Ser Leu Asp Ser Thr Asp Thr Tyr Pro Gln His Ala Gln 
        115                 120                 125             


Ser Leu Asp Gly Thr Thr Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser 
    130                 135                 140                 


Glu Glu Glu Lys Arg Val Thr Val Ile Lys Ala Pro His Tyr Pro Gly 
145                 150                 155                 160 


Ile Gly Pro Val Asp Glu Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr 
                165                 170                 175     


Val Asp Arg Pro Lys Asp Trp Tyr Lys Thr Met Phe Lys Gln Ile His 
            180                 185                 190         


Met Val His Lys Pro Gly Leu Tyr Asn Pro Pro Tyr Ser Ala Gln Ser 
        195                 200                 205             


His Pro Ala Ala Lys Thr Gln Thr Tyr Arg Pro Leu Ser Lys Ser His 
    210                 215                 220                 


Ser Asp Asn Ser Pro Asn Ala Phe Lys Asp Ala Ser Ser Pro Val Pro 
225                 230                 235                 240 


Pro Pro His Val Pro Pro Pro Val Pro Pro Leu Arg Pro Arg Asp Arg 
                245                 250                 255     


Ser Ser Thr Glu Lys His Asp Trp Asp Pro Pro Asp Arg Lys Val Asp 
            260                 265                 270         


Thr Arg Lys Phe Arg Ser Glu Pro Arg Ser Ile Phe Glu Tyr Glu Pro 
        275                 280                 285             


Gly Lys Ser Ser Ile Leu Gln His Glu Arg Pro Ala Ser Leu Tyr Gln 
    290                 295                 300                 


Ser Ser Ile Asp Arg Ser Leu Glu Arg Pro Met Ser Ser Ala Ser Met 
305                 310                 315                 320 


Ala Ser Asp Phe Arg Lys Arg Arg Lys Ser Glu Pro Ala Val Gly Pro 
                325                 330                 335     


Pro Arg Gly Leu Gly Asp Gln Ser Ala Ser Arg Thr Ser Pro Gly Arg 
            340                 345                 350         


Val Asp Leu Pro Gly Ser Ser Thr Thr Leu Thr Lys Ser Phe Thr Ser 
        355                 360                 365             


Ser Ser Pro Ser Ser Pro Ser Arg Ala Lys Asp Arg Glu Ser Pro Arg 
    370                 375                 380                 


Ser Tyr Ser Ser Thr Leu Thr Asp Met Gly Arg Ser Ala Pro Arg Glu 
385                 390                 395                 400 


Arg Arg Gly Thr Pro Glu Lys Glu Lys Leu Pro Ala Lys Ala Val Tyr 
                405                 410                 415     


Asp Phe Lys Ala Gln Thr Ser Lys Glu Leu Ser Phe Lys Lys Gly Asp 
            420                 425                 430         


Thr Val Tyr Ile Leu Arg Lys Ile Asp Gln Asn Trp Tyr Glu Gly Glu 
        435                 440                 445             


His His Gly Arg Val Gly Ile Phe Pro Ile Ser Tyr Val Glu Lys Leu 
    450                 455                 460                 


Thr Pro Pro Glu Lys Ala Gln Pro Ala Arg Pro Pro Pro Pro Ala Gln 
465                 470                 475                 480 


Pro Gly Glu Ile Gly Glu Ala Ile Ala Lys Tyr Asn Phe Asn Ala Asp 
                485                 490                 495     


Thr Asn Val Glu Leu Ser Leu Arg Lys Gly Asp Arg Val Ile Leu Leu 
            500                 505                 510         


Lys Arg Val Asp Gln Asn Trp Tyr Glu Gly Lys Ile Pro Gly Thr Asn 
        515                 520                 525             


Arg Gln Gly Ile Phe Pro Val Ser Tyr Val Glu Val Val Lys Lys Asn 
    530                 535                 540                 


Thr Lys Gly Ala Glu Asp Tyr Pro Asp Pro Pro Ile Pro His Ser Tyr 
545                 550                 555                 560 


Ser Ser Asp Arg Ile His Ser Leu Ser Ser Asn Lys Pro Gln Arg Pro 
                565                 570                 575     


Val Phe Thr His Glu Asn Ile Gln Gly Gly Gly Glu Pro Phe Gln Ala 
            580                 585                 590         


Leu Tyr Asn Tyr Thr Pro Arg Asn Glu Asp Glu Leu Glu Leu Arg Glu 
        595                 600                 605             


Ser Asp Val Ile Asp Val Met Glu Lys Cys Asp Asp Gly Trp Phe Val 
    610                 615                 620                 


Gly Thr Ser Arg Arg Thr Lys Phe Phe Gly Thr Phe Pro Gly Asn Tyr 
625                 630                 635                 640 


Val Lys Arg Leu 
                


<210> 8007
<211> 97
<212> PRT
<213> Homo sapiens

<400> 8007
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Ile Ala Glu Ser Leu Phe Ser Val 
    50                  55                  60                  


Trp Ser Cys Ser Arg Arg Arg Leu Thr Asn Pro Arg Thr Arg Arg Arg 
65                  70                  75                  80  


Ser Pro Ser Trp Ser Leu Ala Thr Ser Val Thr Tyr Arg Ser Ser Gly 
                85                  90                  95      


Val 
    


<210> 8008
<211> 304
<212> PRT
<213> Homo sapiens

<400> 8008
Met Ser Lys Thr His Asp His Gln Leu Glu Ser Ser Leu Ser Pro Val 
1               5                   10                  15      


Glu Val Phe Ala Lys Thr Ser Ala Ser Leu Glu Met Asn Gln Gly Val 
            20                  25                  30          


Ser Glu Glu Arg Ile His Leu Gly Ser Ser Pro Lys Lys Gly Gly Asn 
        35                  40                  45              


Cys Asp Leu Ser His Gln Glu Arg Leu Gln Ser Lys Ser Leu His Leu 
    50                  55                  60                  


Ser Pro Gln Glu Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp 
65                  70                  75                  80  


Arg Arg Ala Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro 
                85                  90                  95      


Ile His Gln Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu 
            100                 105                 110         


Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe 
        115                 120                 125             


Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser 
    130                 135                 140                 


Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys 
145                 150                 155                 160 


His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe 
                165                 170                 175     


Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val 
            180                 185                 190         


Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr 
        195                 200                 205             


Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu 
    210                 215                 220                 


Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro 
225                 230                 235                 240 


Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro 
                245                 250                 255     


Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met 
            260                 265                 270         


Glu Leu Val Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala 
        275                 280                 285             


Phe Met Asp Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu 
    290                 295                 300                 


<210> 8009
<211> 613
<212> PRT
<213> Homo sapiens

<400> 8009
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 8010
<211> 519
<212> PRT
<213> Homo sapiens

<400> 8010
Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln 
1               5                   10                  15      


Pro Arg Trp Phe Leu Leu Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser 
            20                  25                  30          


Pro Glu Asp Ala Trp Lys Gly Cys Lys Gly Ser Ile Gln Met Ala Val 
        35                  40                  45              


Cys Glu Ile Gln Val His Ser Val Asp Asn Thr Arg Met Asp Leu Ile 
    50                  55                  60                  


Ile Pro Gly Glu Gln Tyr Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu 
65                  70                  75                  80  


Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr 
                85                  90                  95      


Asp Ser Arg Thr Gln Lys Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn 
            100                 105                 110         


Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val 
        115                 120                 125             


Gln Gln Val Asp Lys Thr Lys Glu Val Thr Thr Thr Gly Val Ser Asn 
    130                 135                 140                 


Ser Glu Glu Gly Ile Asp Val Gly Thr Leu Leu Lys Ser Thr Cys Asn 
145                 150                 155                 160 


Thr Phe Leu Lys Thr Leu Glu Glu Cys Met Gln Ile Ala Asn Ala Ala 
                165                 170                 175     


Phe Thr Ser Glu Leu Leu Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu 
            180                 185                 190         


Ala Met Leu Lys Ser Ser Lys Met Lys His Pro Ile Ile Pro Ile His 
        195                 200                 205             


Asn Ser Leu Glu Arg Gln Met Glu Leu Ser Thr Cys Glu Asn Gly Ser 
    210                 215                 220                 


Leu Asn Met Glu Ile Asn Gly Glu Glu Glu Ile Leu Met Lys Asn Lys 
225                 230                 235                 240 


Asn Ser Leu Tyr Leu Lys Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser 
                245                 250                 255     


Glu Glu Asn Thr Asp Asp Asn Ile Thr Val Gln Gly Glu Ile Arg Lys 
            260                 265                 270         


Glu Asp Gly Met Glu Asn Leu Lys Asn His Asp Asn Asn Leu Thr Gln 
        275                 280                 285             


Ser Gly Ser Asp Ser Ser Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly 
    290                 295                 300                 


Lys Glu Val Ile Pro Thr Phe Phe Ser Thr Met Asn Thr Ser Phe Ser 
305                 310                 315                 320 


Asp Ile Glu Leu Leu Glu Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu 
                325                 330                 335     


Ala Ser Cys Tyr Ala Val Val Pro Val Leu Asp Lys Leu Gly Pro Thr 
            340                 345                 350         


Val Phe Ala Pro Val Lys Met Asp Leu Val Gly Asn Ile Lys Lys Val 
        355                 360                 365             


Asn Gln Lys Tyr Ile Thr Asn Lys Glu Glu Phe Thr Thr Leu Gln Lys 
    370                 375                 380                 


Ile Val Leu His Glu Val Glu Ala Asp Val Ala Gln Val Arg Asn Ser 
385                 390                 395                 400 


Ala Thr Glu Ala Leu Leu Trp Leu Lys Arg Gly Leu Lys Phe Leu Lys 
                405                 410                 415     


Gly Phe Leu Thr Glu Val Lys Asn Gly Glu Lys Asp Ile Gln Thr Ala 
            420                 425                 430         


Leu Asn Asn Ala Tyr Gly Lys Thr Leu Arg Gln His His Gly Trp Val 
        435                 440                 445             


Val Arg Gly Val Phe Ala Leu Ala Leu Arg Ala Ala Pro Ser Tyr Glu 
    450                 455                 460                 


Asp Phe Val Ala Ala Leu Thr Val Lys Glu Gly Asp His Gln Lys Glu 
465                 470                 475                 480 


Ala Phe Ser Ile Gly Met Gln Arg Asp Leu Ser Leu Tyr Leu Pro Ala 
                485                 490                 495     


Met Glu Lys Gln Leu Ala Ile Leu Asp Thr Leu Tyr Glu Val His Gly 
            500                 505                 510         


Leu Glu Ser Asp Glu Val Val 
        515                 


<210> 8011
<211> 481
<212> PRT
<213> Homo sapiens

<400> 8011
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 8012
<211> 390
<212> PRT
<213> Homo sapiens

<400> 8012
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe 
            340                 345                 350         


His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln 
        355                 360                 365             


Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys 
    370                 375                 380                 


Leu Ile Gln Arg Arg Asp 
385                 390 


<210> 8013
<211> 380
<212> PRT
<213> Homo sapiens

<400> 8013
Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
1               5                   10                  15      


Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
            20                  25                  30          


Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
        35                  40                  45              


Asp Tyr Ala Gly Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser 
    50                  55                  60                  


Thr Gln Ala His Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn 
65                  70                  75                  80  


Gly Ser Leu Thr Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln Ser 
                85                  90                  95      


Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys Arg 
            100                 105                 110         


Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg 
        115                 120                 125             


Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile Phe 
    130                 135                 140                 


Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn Ser 
145                 150                 155                 160 


Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val Glu 
                165                 170                 175     


Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr Asn 
            180                 185                 190         


Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro Val 
        195                 200                 205             


Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe Gln 
    210                 215                 220                 


Ala Asp Val Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly Arg 
225                 230                 235                 240 


Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ser Leu Pro Leu Val Pro 
                245                 250                 255     


Gly Phe Pro Tyr Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly 
            260                 265                 270         


Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala 
        275                 280                 285             


Val Pro Pro Thr Ala Ile Pro Ala Tyr Pro Gly Val Val Tyr Gln Asp 
    290                 295                 300                 


Gly Phe Tyr Gly Ala Asp Leu Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr 
305                 310                 315                 320 


Ala Gln Pro Ala Thr Ala Thr Ala Ala Thr Ala Ala Ala Ala Ala Ala 
                325                 330                 335     


Ala Ala Tyr Ser Asp Gly Tyr Gly Arg Val Tyr Thr Ala Asp Pro Tyr 
            340                 345                 350         


His Ala Leu Ala Pro Ala Ala Ser Tyr Gly Val Gly Ala Val Ala Ser 
        355                 360                 365             


Leu Tyr Arg Gly Gly Tyr Ser Arg Phe Ala Pro Tyr 
    370                 375                 380 


<210> 8014
<211> 537
<212> PRT
<213> Homo sapiens

<400> 8014
Met Asp Pro Gly Asp Ala Ala Ile Leu Glu Ser Ser Leu Arg Ile Leu 
1               5                   10                  15      


Tyr Arg Leu Phe Glu Ser Val Leu Pro Pro Leu Pro Ala Ala Leu Gln 
            20                  25                  30          


Ser Arg Met Asn Val Ile Asp His Val Arg Asp Met Ala Ala Ala Gly 
        35                  40                  45              


Leu His Ser Asn Val Arg Leu Leu Ser Ser Leu Leu Leu Thr Met Ser 
    50                  55                  60                  


Asn Asn Asn Pro Glu Leu Phe Ser Pro Pro Gln Lys Tyr Gln Leu Leu 
65                  70                  75                  80  


Val Tyr His Ala Asp Ser Leu Phe His Asp Lys Glu Tyr Arg Asn Ala 
                85                  90                  95      


Val Ser Lys Tyr Thr Met Ala Leu Gln Gln Lys Lys Ala Leu Ser Lys 
            100                 105                 110         


Thr Ser Lys Val Arg Pro Ser Thr Gly Asn Ser Ala Ser Thr Pro Gln 
        115                 120                 125             


Ser Gln Cys Leu Pro Ser Glu Ile Glu Val Lys Tyr Lys Met Ala Glu 
    130                 135                 140                 


Cys Tyr Thr Met Leu Lys Gln Asp Lys Asp Ala Ile Ala Ile Leu Asp 
145                 150                 155                 160 


Gly Ile Pro Ser Arg Gln Arg Thr Pro Lys Ile Asn Met Met Leu Ala 
                165                 170                 175     


Asn Leu Tyr Lys Lys Ala Gly Gln Glu Arg Pro Ser Val Thr Ser Tyr 
            180                 185                 190         


Lys Glu Val Leu Arg Gln Cys Pro Leu Ala Leu Asp Ala Ile Leu Gly 
        195                 200                 205             


Leu Leu Ser Leu Ser Val Lys Gly Ala Glu Val Ala Ser Met Thr Met 
    210                 215                 220                 


Asn Val Ile Gln Thr Val Pro Asn Leu Asp Trp Leu Ser Val Trp Ile 
225                 230                 235                 240 


Lys Ala Tyr Ala Phe Val His Thr Gly Asp Asn Ser Arg Ala Ile Ser 
                245                 250                 255     


Thr Ile Cys Ser Leu Glu Lys Lys Ser Leu Leu Arg Asp Asn Val Asp 
            260                 265                 270         


Leu Leu Gly Ser Leu Ala Asp Leu Tyr Phe Arg Ala Gly Asp Asn Lys 
        275                 280                 285             


Asn Ser Val Leu Lys Phe Glu Gln Ala Gln Met Leu Asp Pro Tyr Leu 
    290                 295                 300                 


Ile Lys Gly Met Asp Val Tyr Gly Tyr Leu Leu Ala Arg Glu Gly Arg 
305                 310                 315                 320 


Leu Glu Asp Val Glu Asn Leu Gly Cys Arg Leu Phe Asn Ile Ser Asp 
                325                 330                 335     


Gln His Ala Glu Pro Trp Val Val Ser Gly Cys His Ser Phe Tyr Ser 
            340                 345                 350         


Lys Arg Tyr Ser Arg Ala Leu Tyr Leu Gly Ala Lys Ala Ile Gln Leu 
        355                 360                 365             


Asn Ser Asn Ser Val Gln Ala Leu Leu Leu Lys Gly Ala Ala Leu Arg 
    370                 375                 380                 


Asn Met Gly Arg Val Gln Glu Ala Ile Ile His Phe Arg Glu Ala Ile 
385                 390                 395                 400 


Arg Leu Ala Pro Cys Arg Leu Asp Cys Tyr Glu Gly Leu Ile Glu Cys 
                405                 410                 415     


Tyr Leu Ala Ser Asn Ser Ile Arg Glu Ala Met Val Met Ala Asn Asn 
            420                 425                 430         


Val Tyr Lys Thr Leu Gly Ala Asn Ala Gln Thr Leu Thr Leu Leu Ala 
        435                 440                 445             


Thr Val Cys Leu Glu Asp Pro Val Thr Gln Glu Lys Ala Lys Thr Leu 
    450                 455                 460                 


Leu Asp Lys Ala Leu Thr Gln Arg Pro Asp Tyr Ile Lys Ala Val Val 
465                 470                 475                 480 


Lys Lys Ala Glu Leu Leu Ser Arg Glu Gln Lys Tyr Glu Asp Gly Ile 
                485                 490                 495     


Ala Leu Leu Arg Asn Ala Leu Ala Asn Gln Ser Asp Cys Val Leu His 
            500                 505                 510         


Arg Ile Leu Gly Asp Phe Leu Val Ala Val Asn Glu Tyr Gln Glu Ala 
        515                 520                 525             


Met Asp Gln Tyr Ser Ile Ala Leu Arg 
    530                 535         


<210> 8015
<211> 116
<212> PRT
<213> Homo sapiens

<400> 8015
Met Ala Phe Met Thr Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys 
1               5                   10                  15      


Ala Gln Thr Asp Glu Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu 
            20                  25                  30          


Glu Asp Leu Val Gln Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu 
        35                  40                  45              


Gln Arg Gln Glu Glu Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln 
    50                  55                  60                  


Val Arg Glu Met Glu Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val 
65                  70                  75                  80  


Gly Glu Pro Met Asp Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu 
                85                  90                  95      


His Gly Glu Arg Asp Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly 
            100                 105                 110         


Arg Ala Gly Arg 
        115     


<210> 8016
<211> 94
<212> PRT
<213> Homo sapiens

<400> 8016
Met Thr Gly Ser Arg Asn Trp Arg Ala Thr Arg Asp Met Cys Arg Tyr 
1               5                   10                  15      


Arg His Asn Tyr Pro Asp Leu Val Glu Arg Asp Cys Asn Gly Asp Thr 
            20                  25                  30          


Pro Asn Leu Ser Phe Tyr Arg Asn Glu Ile Arg Phe Leu Pro Asn Gly 
        35                  40                  45              


Cys Phe Ile Glu Asp Ile Leu Gln Asn Trp Thr Asp Asn Tyr Asp Leu 
    50                  55                  60                  


Leu Glu Asp Asn His Ser Tyr Ile Gln Trp Leu Phe Pro Leu Arg Glu 
65                  70                  75                  80  


Pro Gly Val Asn Trp His Ala Lys Pro Leu Thr Leu Arg Glu 
                85                  90                  


<210> 8017
<211> 342
<212> PRT
<213> Homo sapiens

<400> 8017
Met Arg Phe Trp Ala Pro Trp Gly Ser Arg Thr Pro Ser Gly Arg Ser 
1               5                   10                  15      


Leu Trp Thr Asp Pro Val Thr Tyr Tyr Thr Ala Leu His Ile Ala Val 
            20                  25                  30          


Leu Arg Asn Gln Pro Asp Met Val Glu Leu Leu Val His His Gly Ala 
        35                  40                  45              


Asp Val Asn Arg Arg Asp Arg Ile His Glu Ser Ser Pro Leu Asp Leu 
    50                  55                  60                  


Ala Ser Glu Glu Pro Glu Arg Leu Pro Cys Leu Gln Arg Leu Leu Asp 
65                  70                  75                  80  


Leu Gly Ala Asp Val Asn Ala Ala Asp Lys His Gly Lys Thr Ala Leu 
                85                  90                  95      


Leu His Ala Leu Ala Ser Ser Asp Gly Val Gln Ile His Asn Thr Glu 
            100                 105                 110         


Asn Ile Arg Leu Leu Leu Glu Gly Gly Ala Asp Val Lys Ala Thr Thr 
        115                 120                 125             


Lys Asp Gly Asp Thr Val Phe Thr Cys Ile Ile Phe Leu Leu Gly Glu 
    130                 135                 140                 


Thr Val Gly Gly Asp Lys Glu Glu Ala Gln Met Ile Asn Arg Phe Cys 
145                 150                 155                 160 


Phe Gln Val Thr Arg Leu Leu Leu Ala His Gly Ala Asp Pro Ser Glu 
                165                 170                 175     


Cys Pro Ala His Glu Ser Leu Thr His Ile Cys Leu Lys Ser Phe Lys 
            180                 185                 190         


Leu His Phe Pro Leu Leu Arg Phe Leu Leu Glu Ser Gly Ala Ala Tyr 
        195                 200                 205             


Asn Cys Ser Leu His Gly Ala Ser Cys Trp Ser Gly Phe His Ile Ile 
    210                 215                 220                 


Phe Glu Arg Leu Cys Ser His Pro Gly Cys Thr Glu Asp Glu Ser His 
225                 230                 235                 240 


Ala Asp Leu Leu Arg Lys Ala Glu Thr Val Leu Asp Leu Met Val Thr 
                245                 250                 255     


Asn Ser Gln Lys Leu Gln Leu Pro Glu Asn Phe Asp Ile His Pro Val 
            260                 265                 270         


Gly Ser Leu Ala Glu Lys Ile Gln Ala Leu His Phe Ser Leu Arg Gln 
        275                 280                 285             


Leu Glu Ser Tyr Pro Pro Pro Leu Lys His Leu Cys Arg Val Ala Ile 
    290                 295                 300                 


Arg Leu Tyr Leu Gln Pro Trp Pro Val Asp Val Lys Val Lys Ala Leu 
305                 310                 315                 320 


Pro Leu Pro Asp Arg Leu Lys Trp Tyr Leu Leu Ser Glu His Ser Gly 
                325                 330                 335     


Ser Val Glu Asp Asp Ile 
            340         


<210> 8018
<211> 1063
<212> PRT
<213> Homo sapiens

<400> 8018
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 
                245                 250                 255     


Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 
            260                 265                 270         


Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 
        275                 280                 285             


Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 
    290                 295                 300                 


Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 
305                 310                 315                 320 


Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr 
                325                 330                 335     


Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro 
            340                 345                 350         


Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro 
        355                 360                 365             


Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro 
    370                 375                 380                 


His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala 
385                 390                 395                 400 


Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile 
                405                 410                 415     


Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly 
            420                 425                 430         


Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu 
        435                 440                 445             


Arg Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile 
    450                 455                 460                 


Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp 
465                 470                 475                 480 


Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu 
                485                 490                 495     


Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln 
            500                 505                 510         


His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp 
        515                 520                 525             


Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln 
    530                 535                 540                 


Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg 
545                 550                 555                 560 


Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu 
                565                 570                 575     


Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe 
            580                 585                 590         


Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg 
        595                 600                 605             


Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe 
    610                 615                 620                 


Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu 
625                 630                 635                 640 


Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly 
                645                 650                 655     


Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile 
            660                 665                 670         


Ile Ser Gly Val Glu Met Gln Leu Leu Gln Glu Lys Leu Arg Ser Gly 
        675                 680                 685             


Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys 
    690                 695                 700                 


Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe 
705                 710                 715                 720 


Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val 
                725                 730                 735     


Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala 
            740                 745                 750         


Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro 
        755                 760                 765             


Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser 
    770                 775                 780                 


Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg 
785                 790                 795                 800 


Glu Leu Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn 
                805                 810                 815     


Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser 
            820                 825                 830         


Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu 
        835                 840                 845             


Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu 
    850                 855                 860                 


Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile 
865                 870                 875                 880 


Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln 
                885                 890                 895     


Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val 
            900                 905                 910         


Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg 
        915                 920                 925             


Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala 
    930                 935                 940                 


Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu 
945                 950                 955                 960 


Leu Pro Pro Gly Thr Ala Ala Pro Ser Gly Trp Ala Gln Ala Pro Leu 
                965                 970                 975     


Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly Leu Val Asp Pro 
            980                 985                 990         


Gln Ile Gln Leu Pro Leu Leu Ala  Ala Arg Arg Tyr Lys  Leu Gln Lys 
        995                 1000                 1005             


Gln Leu  Asp Ser Leu Thr Ala  Arg Thr Pro Ser Glu  Gly Glu Ala 
    1010                 1015                 1020             


Gly Thr  Gln Arg Gln Gln Lys  Leu Ser Ser Leu Gln  Leu Glu Leu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Lys Ala Ala  Ser His Leu Arg Gln  Leu Met Asp 
    1040                 1045                 1050             


Glu Pro  Pro Ala Pro Gly Ser  Pro Glu Leu 
    1055                 1060             


<210> 8019
<211> 31
<212> PRT
<213> Homo sapiens

<400> 8019
Met Ser Asp Glu Val Phe Ser Thr Thr Leu Ala Tyr Thr Lys Ser Pro 
1               5                   10                  15      


Lys Val Thr Lys Arg Thr Thr Phe Gln Asp Glu Leu Ile Arg Ala 
            20                  25                  30      


<210> 8020
<211> 201
<212> PRT
<213> Homo sapiens

<400> 8020
Met Pro Leu Gln Leu Lys Asn Pro Arg Leu Arg Gln Lys Ser Arg Thr 
1               5                   10                  15      


Arg Cys Asn Lys Ser Gln Lys Lys Ala Glu Leu Leu Asp Asn Glu Lys 
            20                  25                  30          


Pro Ala Ala Val Val Ala Pro Ile Thr Thr Gly Tyr Thr Val Lys Ile 
        35                  40                  45              


Ser Asn Tyr Gly Trp Asp Gln Ser Asp Lys Phe Val Lys Ile Tyr Ile 
    50                  55                  60                  


Thr Leu Thr Gly Val His Gln Val Pro Thr Glu Asn Val Gln Val His 
65                  70                  75                  80  


Phe Thr Glu Arg Ser Phe Asp Leu Leu Val Lys Asn Leu Asn Gly Lys 
                85                  90                  95      


Ser Tyr Ser Met Ile Val Asn Asn Leu Leu Lys Pro Ile Ser Val Glu 
            100                 105                 110         


Gly Ser Ser Lys Lys Val Lys Thr Asp Thr Val Leu Ile Leu Cys Arg 
        115                 120                 125             


Lys Lys Val Glu Asn Thr Arg Trp Asp Tyr Leu Thr Gln Val Glu Lys 
    130                 135                 140                 


Glu Cys Lys Glu Lys Glu Lys Pro Ser Tyr Asp Thr Glu Thr Asp Pro 
145                 150                 155                 160 


Ser Glu Gly Leu Met Asn Val Leu Lys Lys Ile Tyr Glu Asp Gly Asp 
                165                 170                 175     


Asp Asp Met Lys Arg Thr Ile Asn Lys Ala Trp Val Glu Ser Arg Glu 
            180                 185                 190         


Lys Gln Ala Lys Gly Asp Thr Glu Phe 
        195                 200     


<210> 8021
<211> 159
<212> PRT
<213> Homo sapiens

<400> 8021
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Glu Lys Ile Leu Asn His Leu Ser Thr 
65                  70                  75                  80  


Leu Arg Arg Asp Arg Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu 
                85                  90                  95      


Ala Asp Ile Leu Ala Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr 
            100                 105                 110         


Ile Val Ala Glu Phe Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu 
        115                 120                 125             


Glu His Leu Leu Glu Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu 
    130                 135                 140                 


Gly Arg Glu Lys Phe Lys Ser Arg Gly Val Gly Glu Leu Ala Arg 
145                 150                 155                 


<210> 8022
<211> 1532
<212> PRT
<213> Homo sapiens

<400> 8022
Met Gln Arg Glu Leu Val Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro 
1               5                   10                  15      


Arg Pro Gly Ser Thr Ala His Pro Pro His Ala Ile Pro Asn Ser Pro 
            20                  25                  30          


Pro Ser Thr Pro Val Pro His Ser Met Pro Pro Ser Pro Ser Arg Ile 
        35                  40                  45              


Pro Tyr Gly Gly Thr Arg Ser Met Val Val Pro Gly Asn Ala Thr Ile 
    50                  55                  60                  


Pro Arg Asp Arg Ile Ser Ser Leu Pro Val Ser Arg Pro Ile Ser Pro 
65                  70                  75                  80  


Ser Pro Ser Ala Ile Leu Glu Arg Arg Asp Val Lys Pro Asp Glu Asp 
                85                  90                  95      


Met Ser Gly Lys Asn Ile Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala 
            100                 105                 110         


Asp Pro Tyr Leu Tyr His Glu Gly Arg Met Ser Ile Ala Ser Ser His 
        115                 120                 125             


Gly Gly His Pro Leu Asp Val Pro Asp His Ile Ile Ala Tyr His Arg 
    130                 135                 140                 


Thr Ala Ile Arg Ser Ala Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala 
145                 150                 155                 160 


Glu Met His Met Glu Gln Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr 
                165                 170                 175     


Pro Asp Ser His Leu Pro Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser 
            180                 185                 190         


Pro His Arg Val Ser Asp Leu Arg Met Ile Asp Met His Ala His Tyr 
        195                 200                 205             


Asn Ala His Gly Pro Pro His Thr Met Gln Pro Asp Arg Ala Ser Pro 
    210                 215                 220                 


Ser Arg Gln Ala Phe Lys Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu 
225                 230                 235                 240 


Lys Pro Arg Ser Ala Ala Gly Leu Ser Ser Leu Val Asp Leu Gly Pro 
                245                 250                 255     


Pro Leu Met Glu Lys Gln Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro 
            260                 265                 270         


Lys Asp Arg Glu Thr Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg 
        275                 280                 285             


Asn His Thr Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met 
    290                 295                 300                 


Leu Ser Ala Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val 
305                 310                 315                 320 


Gly Thr Ser Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val 
                325                 330                 335     


Ala Glu Leu Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln 
            340                 345                 350         


Asn Gln Glu Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile 
        355                 360                 365             


Ser Gly Lys Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln 
    370                 375                 380                 


Arg Gln Arg Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu 
385                 390                 395                 400 


Glu Glu Lys Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu 
                405                 410                 415     


Asp Leu Lys Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys 
            420                 425                 430         


Asp Val Glu Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val 
        435                 440                 445             


Ala Thr Leu Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala 
    450                 455                 460                 


Ile Leu Arg Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro 
465                 470                 475                 480 


His Lys Leu Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val 
                485                 490                 495     


Leu Thr Met Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr 
            500                 505                 510         


Asp Ala Ala Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala 
        515                 520                 525             


Ala Glu Val Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln 
    530                 535                 540                 


Pro Phe His Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val 
545                 550                 555                 560 


Pro Leu Ser Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val 
                565                 570                 575     


Ile Gln Pro Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn 
            580                 585                 590         


Leu Pro His Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser 
        595                 600                 605             


Thr Leu Gln Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn 
    610                 615                 620                 


Gly Ser Ala Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser 
625                 630                 635                 640 


Ala Lys Asn Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu 
                645                 650                 655     


Glu Lys Arg Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys 
            660                 665                 670         


Leu Leu Glu Glu Ala Gln Ala Asn Ile Met Lys Ser Ile Pro Asn Leu 
        675                 680                 685             


Glu Met Pro Pro Ala Thr Gly Pro Leu Pro Arg Gly Asp Ala Pro Val 
    690                 695                 700                 


Asp Lys Val Glu Leu Ser Glu Asp Ser Pro Asn Ser Glu Gln Asp Leu 
705                 710                 715                 720 


Glu Lys Leu Gly Gly Lys Ser Pro Pro Pro Pro Pro Pro Pro Pro Arg 
                725                 730                 735     


Arg Ser Tyr Leu Pro Gly Ser Gly Leu Thr Thr Thr Arg Ser Gly Asp 
            740                 745                 750         


Val Val Tyr Thr Gly Arg Lys Glu Asn Ile Thr Ala Lys Ala Ser Ser 
        755                 760                 765             


Glu Asp Ala Gly Pro Ser Pro Gln Thr Arg Ala Thr Lys Tyr Pro Ala 
    770                 775                 780                 


Glu Glu Pro Ala Ser Ala Trp Thr Pro Ser Pro Pro Pro Val Thr Thr 
785                 790                 795                 800 


Ser Ser Ser Lys Asp Glu Glu Glu Glu Glu Glu Glu Gly Asp Lys Ile 
                805                 810                 815     


Met Ala Glu Leu Gln Ala Phe Gln Lys Cys Ser Phe Met Asp Val Asn 
            820                 825                 830         


Ser Asn Ser His Ala Glu Pro Ser Arg Ala Asp Ser His Val Lys Asp 
        835                 840                 845             


Thr Arg Ser Gly Ala Thr Val Pro Pro Lys Glu Lys Lys Asn Leu Glu 
    850                 855                 860                 


Phe Phe His Glu Asp Val Arg Lys Ser Asp Val Glu Tyr Glu Asn Gly 
865                 870                 875                 880 


Pro Gln Met Glu Phe Gln Lys Val Thr Thr Gly Ala Val Arg Pro Ser 
                885                 890                 895     


Asp Pro Pro Lys Trp Glu Arg Gly Met Glu Asn Ser Ile Ser Asp Ala 
            900                 905                 910         


Ser Arg Thr Ser Glu Tyr Lys Thr Glu Ile Ile Met Lys Glu Asn Ser 
        915                 920                 925             


Ile Ser Asn Met Ser Leu Leu Arg Asp Ser Arg Asn Tyr Ser Gln Glu 
    930                 935                 940                 


Thr Val Pro Lys Ala Ser Phe Gly Phe Ser Gly Ile Ser Pro Leu Glu 
945                 950                 955                 960 


Asp Glu Ile Asn Lys Gly Ser Lys Ile Ser Gly Leu Gln Tyr Ser Ile 
                965                 970                 975     


Pro Asp Thr Glu Asn Gln Thr Leu Asn Tyr Gly Lys Thr Lys Glu Met 
            980                 985                 990         


Glu Lys Gln Asn Thr Asp Lys Cys  His Val Ser Ser His  Thr Arg Leu 
        995                 1000                 1005             


Thr Glu  Ser Ser Val His Asp  Phe Lys Thr Glu Asp  Gln Glu Val 
    1010                 1015                 1020             


Ile Thr  Thr Asp Phe Gly Gln  Val Val Leu Arg Pro  Lys Glu Ala 
    1025                 1030                 1035             


Arg His  Ala Asn Val Asn Pro  Asn Glu Asp Gly Glu  Ser Ser Ser 
    1040                 1045                 1050             


Ser Ser  Pro Thr Glu Glu Asn  Ala Ala Thr Asp Asn  Ile Ala Phe 
    1055                 1060                 1065             


Met Ile  Thr Glu Thr Thr Val  Gln Val Leu Ser Ser  Gly Glu Val 
    1070                 1075                 1080             


His Asp  Ile Val Ser Gln Lys  Gly Glu Asp Ile Gln  Thr Val Asn 
    1085                 1090                 1095             


Ile Asp  Ala Arg Lys Glu Met  Thr Pro Arg Gln Glu  Gly Thr Asp 
    1100                 1105                 1110             


Asn Glu  Asp Pro Val Val Cys  Leu Asp Lys Lys Pro  Val Ile Ile 
    1115                 1120                 1125             


Ile Phe  Asp Glu Pro Met Asp  Ile Arg Ser Ala Tyr  Lys Arg Leu 
    1130                 1135                 1140             


Ser Thr  Ile Phe Glu Glu Cys  Asp Glu Glu Leu Glu  Arg Met Met 
    1145                 1150                 1155             


Met Glu  Glu Lys Ile Glu Glu  Glu Glu Glu Glu Glu  Asn Gly Asp 
    1160                 1165                 1170             


Ser Val  Val Gln Asn Asn Asn  Thr Ser Gln Met Ser  His Lys Lys 
    1175                 1180                 1185             


Val Ala  Pro Gly Asn Leu Arg  Thr Gly Gln Gln Val  Glu Thr Lys 
    1190                 1195                 1200             


Ser Gln  Pro His Ser Leu Ala  Thr Glu Thr Arg Asn  Pro Gly Gly 
    1205                 1210                 1215             


Gln Glu  Met Asn Arg Thr Glu  Leu Asn Lys Phe Ser  His Val Asp 
    1220                 1225                 1230             


Ser Pro  Asn Ser Glu Cys Lys  Gly Glu Asp Ala Thr  Asp Asp Gln 
    1235                 1240                 1245             


Phe Glu  Ser Pro Lys Lys Lys  Phe Lys Phe Lys Phe  Pro Lys Lys 
    1250                 1255                 1260             


Gln Leu  Ala Ala Leu Thr Gln  Ala Ile Arg Thr Gly  Thr Lys Thr 
    1265                 1270                 1275             


Gly Lys  Lys Thr Leu Gln Val  Val Val Tyr Glu Glu  Glu Glu Glu 
    1280                 1285                 1290             


Asp Gly  Thr Leu Lys Gln His  Lys Glu Ala Lys Arg  Phe Glu Ile 
    1295                 1300                 1305             


Ala Arg  Ser Gln Pro Glu Asp  Thr Pro Thr Ser Ile  Pro Ser Ala 
    1310                 1315                 1320             


Ser Arg  Lys Gly Ser Ser Gly  Ala Pro Gln Thr Ser  Arg Met Pro 
    1325                 1330                 1335             


Val Pro  Met Ser Ala Lys Asn  Arg Pro Gly Thr Leu  Asp Lys Pro 
    1340                 1345                 1350             


Gly Lys  Gln Ser Lys Leu Gln  Asp Pro Arg Gln Tyr  Arg Gln Ala 
    1355                 1360                 1365             


Asn Gly  Ser Ala Lys Lys Ser  Gly Gly Asp Phe Lys  Pro Thr Ser 
    1370                 1375                 1380             


Pro Ser  Leu Pro Ala Ser Lys  Ile Pro Ala Leu Ser  Pro Ser Ser 
    1385                 1390                 1395             


Gly Lys  Ser Ser Ser Leu Pro  Ser Ser Ser Gly Asp  Ser Ser Asn 
    1400                 1405                 1410             


Leu Pro  Asn Pro Pro Ala Thr  Lys Pro Ser Ile Ala  Ser Asn Pro 
    1415                 1420                 1425             


Leu Ser  Pro Gln Thr Gly Pro  Pro Ala His Ser Ala  Ser Leu Ile 
    1430                 1435                 1440             


Pro Ser  Val Ser Asn Gly Ser  Leu Lys Phe Gln Ser  Leu Thr His 
    1445                 1450                 1455             


Thr Gly  Lys Gly His His Leu  Ser Phe Ser Pro Gln  Ser Gln Asn 
    1460                 1465                 1470             


Gly Arg  Ala Pro Pro Pro Leu  Ser Phe Ser Ser Ser  Pro Pro Ser 
    1475                 1480                 1485             


Pro Ala  Ser Ser Val Ser Leu  Asn Gln Gly Ala Lys  Gly Thr Arg 
    1490                 1495                 1500             


Thr Ile  His Thr Pro Ser Leu  Thr Ser Tyr Lys Ala  Gln Asn Gly 
    1505                 1510                 1515             


Ser Ser  Ser Lys Ala Thr Pro  Ser Thr Ala Lys Glu  Thr Ser 
    1520                 1525                 1530         


<210> 8023
<211> 521
<212> PRT
<213> Homo sapiens

<400> 8023
Met Thr Ser Ala Phe Lys Leu Asp Phe Leu Pro Asp Met Met Val Glu 
1               5                   10                  15      


Gly Arg Leu Leu Val Pro Asp Arg Ile Asn Gly Thr Ala Asn Lys Met 
            20                  25                  30          


Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile Lys 
        35                  40                  45              


Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu Lys 
    50                  55                  60                  


Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu Arg 
65                  70                  75                  80  


Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val Thr 
                85                  90                  95      


Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His Asn 
            100                 105                 110         


Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro Ala 
        115                 120                 125             


Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile Gly 
    130                 135                 140                 


Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe Ser 
145                 150                 155                 160 


Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp Gly 
                165                 170                 175     


Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met Ala 
            180                 185                 190         


Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly Cys 
        195                 200                 205             


Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys Glu 
    210                 215                 220                 


Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu Asn 
225                 230                 235                 240 


Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro Gln 
                245                 250                 255     


Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly Ala 
            260                 265                 270         


Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu Gln 
        275                 280                 285             


Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser Ala 
    290                 295                 300                 


Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu Gly 
305                 310                 315                 320 


Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala Gly 
                325                 330                 335     


Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu Ala 
            340                 345                 350         


Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Val Ala Gln 
        355                 360                 365             


Met Leu Ser Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr Gly 
    370                 375                 380                 


Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala Tyr 
385                 390                 395                 400 


Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr Ser 
                405                 410                 415     


Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu Gly 
            420                 425                 430         


Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly 
        435                 440                 445             


Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile Ser 
    450                 455                 460                 


Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly 
465                 470                 475                 480 


Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln Ala 
                485                 490                 495     


Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys 
            500                 505                 510         


Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
        515                 520     


<210> 8024
<211> 104
<212> PRT
<213> Homo sapiens

<400> 8024
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Glu Ser Ile His Leu Gln Leu Ser Ser 
                85                  90                  95      


Phe Ser Ser Leu Gln Glu Glu Asp 
            100                 


<210> 8025
<211> 550
<212> PRT
<213> Homo sapiens

<400> 8025
Met Glu Pro Pro Gln Glu Thr Asn Arg Pro Phe Ser Thr Leu Asp Asn 
1               5                   10                  15      


Arg Ser Gly Gln Val Gln Val Leu Ser Ala Thr Pro Leu Leu Gln Arg 
            20                  25                  30          


Asn Pro Tyr Ser Ser Pro Asp Ile Met His Ile Lys Gly Ser Glu Ala 
        35                  40                  45              


Ser Ser Val Pro Tyr Ala Leu Asn Gln Gly Thr Thr Ala Leu Pro Lys 
    50                  55                  60                  


Asn Lys Asn Gln Glu Gly Thr Gly His Arg Leu Leu Asn Met Leu Arg 
65                  70                  75                  80  


Lys Thr Leu Lys Glu Ser Asp Ser Glu Glu Leu Glu Ile Thr Gln Glu 
                85                  90                  95      


Thr Pro Asn Leu Val Pro Phe Gly Asp Val Val Gly Cys Leu Gly Ile 
            100                 105                 110         


His Ile Lys Asn Cys Arg His Phe Met Pro Lys Ile Ser Leu Gln His 
        115                 120                 125             


Tyr Ala Asn Leu Phe Ile Arg Ile Ser Ile Asn Lys Ala Val Lys Cys 
    130                 135                 140                 


Thr Lys Met Cys Ser Leu Leu Ser Lys Asn Asp Glu Lys Asn Thr Val 
145                 150                 155                 160 


Ile Lys Phe Asp Glu Val Lys Tyr Phe Ser Val Gln Val Pro Arg Arg 
                165                 170                 175     


Tyr Asp Asp Lys Arg Asn Asn Ile Leu Leu Glu Leu Ile Gln Tyr Asp 
            180                 185                 190         


Asn Arg Glu Lys Arg Ala Phe Leu Leu Gly Ser Val Gln Ile His Leu 
        195                 200                 205             


Tyr Glu Val Ile Gln Lys Gly Cys Phe Ile Glu Glu Val Gln Val Leu 
    210                 215                 220                 


His Gly Asn Ile Phe Val Cys Arg Leu Glu Val Glu Phe Met Phe Ser 
225                 230                 235                 240 


Tyr Gly Asn Phe Gly Tyr Gly Phe Ser His Gln Leu Lys Pro Leu Gln 
                245                 250                 255     


Lys Ile Thr Glu Pro Ser Met Phe Met Asn Leu Ala Pro Pro Pro Glu 
            260                 265                 270         


Arg Thr Asp Pro Val Thr Lys Val Ile Thr Pro Gln Thr Val Glu Tyr 
        275                 280                 285             


Pro Ala Phe Leu Ser Pro Asp Leu Asn Val Thr Val Gly Thr Pro Ala 
    290                 295                 300                 


Val Gln Ser Ser Asn Gln Pro Ser Val Val Arg Leu Glu Lys Leu Gln 
305                 310                 315                 320 


Gln Gln Pro Arg Glu Arg Leu Glu Lys Met Lys Lys Glu Tyr Arg Asn 
                325                 330                 335     


Leu Asn Thr Trp Ile Asp Lys Ala Asn Tyr Leu Glu Ser Ile Leu Met 
            340                 345                 350         


Pro Lys Leu Glu His Lys Asp Ser Glu Glu Thr Asn Ile Asp Glu Ala 
        355                 360                 365             


Ser Glu Asn Thr Lys Ser Asn His Pro Glu Glu Glu Leu Glu Asn Ile 
    370                 375                 380                 


Val Gly Val Asp Ile Pro Leu Val Asn Glu Glu Ala Glu Thr Thr Ala 
385                 390                 395                 400 


Asn Glu Leu Leu Asp Asn Asp Ser Glu Lys Gly Leu Thr Ile Pro Thr 
                405                 410                 415     


Leu Asn Gln Ser Asp Gln Asp Asn Ser Thr Ala Asp Ala Ser Lys Asn 
            420                 425                 430         


Asp Glu Ser Thr Pro Ser Pro Thr Glu Val His Ser Leu Cys Thr Ile 
        435                 440                 445             


Ser Asn Gln Glu Thr Ile Lys Ala Gly Arg Ile Pro Pro Leu Gly Glu 
    450                 455                 460                 


Arg Gln Ser Glu Ser Met Pro Asp Arg Lys Met Lys Asn Val Phe Phe 
465                 470                 475                 480 


Pro Leu Glu Val Lys Leu Lys Asp Asn Tyr Pro Ser Ile Leu Lys Ala 
                485                 490                 495     


Asp Ser Ser Leu Ser Glu Val Asn Leu Arg Ser Ile Cys Ile Asn Pro 
            500                 505                 510         


Lys Ser Arg Asn Leu Asp Ser Ser Pro Thr Glu Ile Ser Trp Gln Asn 
        515                 520                 525             


Asn Asn Leu Asn Leu Ala Glu Arg Glu Asn Thr Gly Leu Val Ser Thr 
    530                 535                 540                 


Arg Leu Lys Ile Lys Arg 
545                 550 


<210> 8026
<211> 120
<212> PRT
<213> Homo sapiens

<400> 8026
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln Thr Arg Gln 
                85                  90                  95      


Gln Ala Tyr Arg Asp Lys Leu Ala Gln Gln Gln Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ser Gln 
        115                 120 


<210> 8027
<211> 73
<212> PRT
<213> Homo sapiens

<400> 8027
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro 
65                  70              


<210> 8028
<211> 238
<212> PRT
<213> Homo sapiens

<400> 8028
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala 
        35                  40                  45              


Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala 
    50                  55                  60                  


Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro 
                85                  90                  95      


Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys 
            100                 105                 110         


Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr 
        115                 120                 125             


Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro 
    130                 135                 140                 


Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr 
                165                 170                 175     


Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser 
            180                 185                 190         


Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu 
        195                 200                 205             


Val Phe Val Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met 
    210                 215                 220                 


Ala Leu Asn Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn 
225                 230                 235             


<210> 8029
<211> 539
<212> PRT
<213> Homo sapiens

<400> 8029
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 8030
<211> 202
<212> PRT
<213> Homo sapiens

<400> 8030
Met Gly Gln Lys Val Thr Gly Gly Ile Lys Thr Val Asp Met Arg Asp 
1               5                   10                  15      


Pro Thr Tyr Arg Pro Leu Lys Gln Glu Leu Gln Gly Leu Asp Tyr Cys 
            20                  25                  30          


Lys Pro Thr Arg Leu Asp Leu Leu Leu Asp Met Pro Pro Val Ser Tyr 
        35                  40                  45              


Asp Val Gln Leu Leu His Ser Trp Asn Asn Asn Asp Arg Ser Leu Asn 
    50                  55                  60                  


Val Phe Val Lys Glu Asp Asp Lys Leu Ile Phe His Arg His Pro Val 
65                  70                  75                  80  


Ala Gln Ser Thr Asp Ala Ile Arg Gly Lys Val Gly Tyr Thr Arg Gly 
                85                  90                  95      


Leu His Val Trp Gln Ile Thr Trp Ala Met Arg Gln Arg Gly Thr His 
            100                 105                 110         


Ala Val Val Gly Val Ala Thr Ala Asp Ala Pro Leu His Ser Val Gly 
        115                 120                 125             


Tyr Thr Thr Leu Val Gly Asn Asn His Glu Ser Trp Gly Trp Asp Leu 
    130                 135                 140                 


Gly Arg Asn Arg Leu Tyr His Asp Gly Lys Asn Gln Pro Ser Lys Thr 
145                 150                 155                 160 


Tyr Pro Ala Phe Leu Glu Pro Asp Glu Thr Phe Ile Val Pro Asp Ser 
                165                 170                 175     


Phe Leu Val Ala Leu Asp Met Asp Asp Gly Thr Leu Ser Phe Ile Val 
            180                 185                 190         


Asp Gly Gln Tyr Met Gly Val Ala Phe Arg 
        195                 200         


<210> 8031
<211> 57
<212> PRT
<213> Homo sapiens

<400> 8031
Asn Leu Pro Ile Cys Met Ala Lys Thr His Leu Ser Leu Ser His Gln 
1               5                   10                  15      


Pro Asp Lys Lys Gly Val Pro Arg Asp Phe Ile Leu Pro Ile Ser Asp 
            20                  25                  30          


Val Arg Ala Ser Ile Gly Ala Gly Phe Ile Tyr Pro Leu Val Gly Thr 
        35                  40                  45              


Gly Gly Arg Glu Ala Pro Leu Trp Leu 
    50                  55          


<210> 8032
<211> 155
<212> PRT
<213> Homo sapiens

<400> 8032
Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe 
1               5                   10                  15      


Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe 
            20                  25                  30          


Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu 
        35                  40                  45              


Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg 
    50                  55                  60                  


Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu 
65                  70                  75                  80  


Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys 
                85                  90                  95      


Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln 
            100                 105                 110         


Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe 
        115                 120                 125             


Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu 
    130                 135                 140                 


Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly 
145                 150                 155 


<210> 8033
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8033
Xaa Phe Asp Asp Gln Arg Arg Met Ser Leu His Leu His Gly Ala Asp 
1               5                   10                  15      


Cys Asp Pro Lys Thr Gln Asn Glu Met Asn Ile Cys Glu Glu Glu Phe 
            20                  25                  30          


Val Glu Tyr Lys Asn Arg Asp Ala Ile Ser Ala Leu Met Pro Leu Phe 
        35                  40                  45              


Ser Glu Glu Glu Ser Ser Asp Gly Ser Lys His Asn Asn Gly Leu Pro 
    50                  55                  60                  


Asp His Ile Ser Ala Gln Leu Gln Asn Thr Tyr Thr Leu Lys Ala Phe 
65                  70                  75                  80  


Thr Val Gly Ser Lys Cys Val Val Trp Ser Ser Leu Arg Asn Thr Trp 
                85                  90                  95      


Ser Lys Cys Glu Ile Leu Glu Thr Ala Glu Glu Gly Thr Arg Val Leu 
            100                 105                 110         


Asn Leu Ser Asn Gly Met Glu Glu Ile Val Asn Pro Glu Asn Val Trp 
        115                 120                 125             


Asn Gly Ile Pro Lys Leu Asp Lys Ser Pro Pro Glu Ala Val Ser Gln 
    130                 135                 140                 


Arg Val Gly Lys Asp Leu Tyr Phe Met Ser Val Gly Asp Thr Thr Ile 
145                 150                 155                 160 


Lys Glu Lys Gly Phe Gly Gly Asp Gly Asp Leu Thr Val Asp Leu 
                165                 170                 175 


<210> 8034
<211> 937
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8034
Xaa Leu Arg Ser Gln Pro Gly Cys Gly Cys Leu Trp Gln Glu Ala Pro 
1               5                   10                  15      


Thr His Ser Thr Gly Pro Ser Val Glu Gly Glu Ala Pro Ser Ser Glu 
            20                  25                  30          


Thr Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro Leu 
        35                  40                  45              


Val Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser Val 
    50                  55                  60                  


Gly Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg Thr 
65                  70                  75                  80  


Arg Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln Ala 
                85                  90                  95      


Glu Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr Glu 
            100                 105                 110         


Leu Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg Lys 
        115                 120                 125             


Tyr Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln Thr 
    130                 135                 140                 


Ala Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg Ser 
145                 150                 155                 160 


Ser Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn Met 
                165                 170                 175     


Arg Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser Tyr 
            180                 185                 190         


Phe Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu Gly 
        195                 200                 205             


Ala Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr Leu 
    210                 215                 220                 


Lys Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu Leu 
225                 230                 235                 240 


Glu Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile Asp 
                245                 250                 255     


Asp Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala Leu 
            260                 265                 270         


Asp Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His Gly 
        275                 280                 285             


Met Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp Val 
    290                 295                 300                 


Thr Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu Ser 
305                 310                 315                 320 


Gln Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu Arg 
                325                 330                 335     


Ala Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu Asp 
            340                 345                 350         


Lys Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu Arg 
        355                 360                 365             


Gln Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile Glu 
    370                 375                 380                 


Pro Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg Gly 
385                 390                 395                 400 


Ser Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln Gln 
                405                 410                 415     


Gly Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu Pro 
            420                 425                 430         


Arg Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp Ser 
        435                 440                 445             


His Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu Ser 
    450                 455                 460                 


Asp Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn Ser 
465                 470                 475                 480 


Asn Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser Leu 
                485                 490                 495     


Arg Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg Asn 
            500                 505                 510         


Ser Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg His 
        515                 520                 525             


Tyr Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly Val 
    530                 535                 540                 


Gln Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly Val 
545                 550                 555                 560 


Ala His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile Gly 
                565                 570                 575     


Glu Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu Asp 
            580                 585                 590         


Cys Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu Ala 
        595                 600                 605             


Leu Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln Lys 
    610                 615                 620                 


Val Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys Asn 
625                 630                 635                 640 


Pro Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile Leu 
                645                 650                 655     


Ala Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn Val 
            660                 665                 670         


Lys Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu Arg 
        675                 680                 685             


Gly Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly Ile 
    690                 695                 700                 


Tyr Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His Val 
705                 710                 715                 720 


Ser Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro Ile 
                725                 730                 735     


Gly Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His Arg 
            740                 745                 750         


Arg Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn Lys 
        755                 760                 765             


Pro Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn Asp 
    770                 775                 780                 


Leu Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val Thr 
785                 790                 795                 800 


Tyr Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu Leu 
                805                 810                 815     


Phe Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser Val 
            820                 825                 830         


Pro Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn Pro 
        835                 840                 845             


Gln Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala Glu 
    850                 855                 860                 


Val Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys Gln 
865                 870                 875                 880 


Lys Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys Lys 
                885                 890                 895     


Glu Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser Tyr 
            900                 905                 910         


Ala Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu Arg 
        915                 920                 925             


Asp Leu Ser Glu Ala Gly Val His His 
    930                 935         


<210> 8035
<211> 65
<212> PRT
<213> Homo sapiens

<400> 8035
Met Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu 
1               5                   10                  15      


Glu Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu 
            20                  25                  30          


Glu Ser Ile Thr Lys Gly Asp Leu Glu Gln Lys Ser Gln Ile Ser Glu 
        35                  40                  45              


Asp Pro Glu Asn Val Ala Thr Val Ser Glu Lys Ser Arg Ile Met Glu 
    50                  55                  60                  


Leu 
65  


<210> 8036
<211> 209
<212> PRT
<213> Homo sapiens

<400> 8036
Met Asp Phe Leu Leu Gly Asn Pro Phe Ser Ser Pro Val Gly Gln Arg 
1               5                   10                  15      


Ile Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Ala Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe 
    50                  55                  60                  


His Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn 
65                  70                  75                  80  


Cys Gly His Arg Phe His Val Leu Val Ala Ser Gln Asp Phe Val Glu 
                85                  90                  95      


Ser Val Leu Val Arg Thr Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile 
            100                 105                 110         


Val His Asp Lys Val Leu Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe 
        115                 120                 125             


Arg Ser Ser Pro Asp Leu Thr Gly Val Val Thr Ile Tyr Glu Asp Leu 
    130                 135                 140                 


Arg Arg Lys Gly Leu Glu Phe Pro Met Thr Asp Leu Asp Met Leu Ser 
145                 150                 155                 160 


Pro Ile His Thr Pro Arg Gly Pro Cys Ser Thr Gln Arg His Asn Gln 
                165                 170                 175     


Asp Arg Ile Leu Trp Ala Leu Thr Pro Ala Ser Lys Arg Thr Leu Ala 
            180                 185                 190         


Ser Met Leu Pro Leu Cys Pro Pro Arg Pro Tyr Ser Pro Val Thr Arg 
        195                 200                 205             


Pro 
    


<210> 8037
<211> 84
<212> PRT
<213> Homo sapiens

<400> 8037
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Ala Gly Asn Pro Leu Val Gln 
        35                  40                  45              


Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn Pro Ala Pro Gly Leu 
    50                  55                  60                  


Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro Val Gln Val Met Gln 
65                  70                  75                  80  


Asn Ala Asn His 
                


<210> 8038
<211> 205
<212> PRT
<213> Homo sapiens

<400> 8038
Met Ala Thr Pro Leu Gly Trp Ser Lys Ala Gly Ser Gly Ser Val Cys 
1               5                   10                  15      


Leu Ala Leu Asp Gln Leu Arg Asp Val Ile Glu Ser Gln Glu Glu Leu 
            20                  25                  30          


Ile His Gln Leu Arg Asn Val Met Val Leu Gln Asp Glu Asn Phe Val 
        35                  40                  45              


Ser Lys Glu Glu Phe Gln Ala Val Glu Lys Lys Leu Val Glu Glu Lys 
    50                  55                  60                  


Ala Ala His Ala Lys Thr Lys Val Leu Leu Ala Lys Glu Glu Glu Lys 
65                  70                  75                  80  


Leu Gln Phe Ala Leu Gly Glu Val Glu Val Leu Ser Lys Gln Leu Glu 
                85                  90                  95      


Lys Glu Lys Leu Ala Phe Glu Lys Ala Leu Ser Ser Val Lys Ser Lys 
            100                 105                 110         


Val Leu Gln Glu Ser Ser Lys Lys Asp Gln Leu Ile Thr Lys Cys Asn 
        115                 120                 125             


Glu Ile Glu Ser His Ile Ile Lys Gln Glu Asp Ile Leu Asn Gly Lys 
    130                 135                 140                 


Glu Asn Glu Ile Lys Glu Leu Gln Gln Val Ile Ser Gln Gln Lys Gln 
145                 150                 155                 160 


Ile Phe Arg Asn His Met Ser Asp Phe Arg Ile Gln Lys Gln Gln Glu 
                165                 170                 175     


Ser Tyr Met Ala Gln Val Leu Asp Gln Lys His Lys Lys Ala Ser Gly 
            180                 185                 190         


Thr Arg Gln Ala Arg Ser His Gln His Pro Arg Glu Lys 
        195                 200                 205 


<210> 8039
<211> 109
<212> PRT
<213> Homo sapiens

<400> 8039
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Thr Thr Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Thr Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro Pro Ser Phe 
            100                 105                 


<210> 8040
<211> 578
<212> PRT
<213> Homo sapiens

<400> 8040
Met Pro Glu Ile Arg Val Thr Pro Leu Gly Ala Gly Gln Asp Val Gly 
1               5                   10                  15      


Arg Ser Cys Ile Leu Val Ser Ile Ala Gly Lys Asn Val Met Leu Asp 
            20                  25                  30          


Cys Gly Met His Met Gly Phe Asn Asp Asp Arg Arg Phe Pro Asp Phe 
        35                  40                  45              


Ser Tyr Ile Thr Gln Asn Gly Arg Leu Thr Asp Phe Leu Asp Cys Val 
    50                  55                  60                  


Ile Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu Pro Tyr Phe 
65                  70                  75                  80  


Ser Glu Met Val Gly Tyr Asp Gly Pro Ile Tyr Met Thr His Pro Thr 
                85                  90                  95      


Gln Ala Ile Cys Pro Ile Leu Leu Glu Asp Tyr Arg Lys Ile Ala Val 
            100                 105                 110         


Asp Lys Lys Gly Glu Ala Asn Phe Phe Thr Ser Gln Met Ile Lys Asp 
        115                 120                 125             


Cys Met Lys Lys Val Val Ala Val His Leu His Gln Thr Val Gln Ile 
    130                 135                 140                 


Lys Val Gly Ser Glu Ser Val Val Tyr Thr Gly Asp Tyr Asn Met Thr 
145                 150                 155                 160 


Pro Asp Arg His Leu Gly Ala Ala Trp Ile Asp Lys Cys Arg Pro Asn 
                165                 170                 175     


Leu Leu Ile Thr Glu Ser Thr Tyr Ala Thr Thr Ile Arg Asp Ser Lys 
            180                 185                 190         


Arg Cys Arg Glu Arg Asp Phe Leu Lys Lys Val His Glu Thr Val Glu 
        195                 200                 205             


Arg Gly Gly Lys Val Leu Ile Pro Val Phe Ala Leu Gly Arg Ala Gln 
    210                 215                 220                 


Glu Leu Cys Ile Leu Leu Glu Thr Phe Trp Glu Arg Met Asn Leu Lys 
225                 230                 235                 240 


Val Pro Ile Tyr Phe Ser Thr Gly Leu Thr Glu Lys Ala Asn His Tyr 
                245                 250                 255     


Tyr Lys Leu Phe Ile Pro Trp Thr Asn Gln Lys Ile Arg Lys Thr Phe 
            260                 265                 270         


Val Gln Arg Asn Met Phe Glu Phe Lys His Ile Lys Ala Phe Asp Arg 
        275                 280                 285             


Ala Phe Ala Asp Asn Pro Gly Pro Met Val Val Phe Ala Thr Pro Gly 
    290                 295                 300                 


Met Leu His Ala Gly Gln Ser Leu Gln Ile Phe Arg Lys Trp Ala Gly 
305                 310                 315                 320 


Asn Glu Lys Asn Met Val Ile Met Pro Gly Tyr Cys Val Gln Gly Thr 
                325                 330                 335     


Val Gly His Lys Ile Leu Ser Gly Gln Arg Lys Leu Glu Met Glu Gly 
            340                 345                 350         


Arg Gln Val Leu Glu Val Lys Met Gln Val Glu Tyr Met Ser Phe Ser 
        355                 360                 365             


Ala His Ala Asp Ala Lys Gly Ile Met Gln Leu Val Gly Gln Ala Glu 
    370                 375                 380                 


Pro Glu Ser Val Leu Leu Val His Gly Glu Ala Lys Lys Met Glu Phe 
385                 390                 395                 400 


Leu Lys Gln Lys Ile Glu Gln Glu Leu Arg Val Asn Cys Tyr Met Pro 
                405                 410                 415     


Ala Asn Gly Glu Thr Val Thr Leu Pro Thr Ser Pro Ser Ile Pro Val 
            420                 425                 430         


Gly Ile Ser Leu Gly Leu Leu Lys Arg Glu Met Ala Gln Gly Leu Leu 
        435                 440                 445             


Pro Glu Ala Lys Lys Pro Arg Leu Leu His Gly Thr Leu Ile Met Lys 
    450                 455                 460                 


Asp Ser Asn Phe Arg Leu Val Ser Ser Glu Gln Ala Leu Lys Glu Leu 
465                 470                 475                 480 


Gly Leu Ala Glu His Gln Leu Arg Phe Thr Cys Arg Val His Leu His 
                485                 490                 495     


Asp Thr Arg Lys Glu Gln Glu Thr Ala Leu Arg Val Tyr Ser His Leu 
            500                 505                 510         


Lys Ser Val Leu Lys Asp His Cys Val Gln His Leu Pro Asp Gly Ser 
        515                 520                 525             


Val Thr Val Glu Ser Val Leu Leu Gln Ala Ala Ala Pro Ser Glu Asp 
    530                 535                 540                 


Pro Gly Thr Lys Val Leu Leu Val Ser Trp Thr Tyr Gln Asp Glu Glu 
545                 550                 555                 560 


Leu Gly Ser Phe Leu Thr Ser Leu Leu Lys Lys Gly Leu Pro Gln Ala 
                565                 570                 575     


Pro Ser 
        


<210> 8041
<211> 189
<212> PRT
<213> Homo sapiens

<400> 8041
Met Gln Pro Met Ser Phe Gly Trp Asp His Ser Leu His Lys Arg Lys 
1               5                   10                  15      


Arg Leu Pro Pro Val Lys Arg Ser Leu Val Tyr Tyr Leu Lys Asn Arg 
            20                  25                  30          


Glu Val Arg Leu Gln Asn Glu Thr Ser Tyr Ser Arg Val Leu His Gly 
        35                  40                  45              


Tyr Ala Ala Gln Gln Leu Pro Ser Leu Leu Lys Glu Arg Glu Phe His 
    50                  55                  60                  


Leu Gly Thr Leu Asn Lys Val Phe Ala Ser Gln Trp Leu Asn His Arg 
65                  70                  75                  80  


Gln Val Val Cys Gly Thr Lys Cys Asn Thr Leu Phe Val Val Asp Val 
                85                  90                  95      


Gln Thr Ser Gln Ile Thr Lys Ile Pro Ile Leu Lys Asp Arg Glu Pro 
            100                 105                 110         


Gly Gly Val Thr Gln Gln Gly Cys Gly Ile His Ala Ile Glu Leu Asn 
        115                 120                 125             


Pro Ser Arg Thr Leu Leu Ala Thr Gly Gly Asp Asn Pro Asn Ser Leu 
    130                 135                 140                 


Ala Ile Tyr Arg Leu Pro Thr Leu Asp Pro Val Cys Val Gly Asp Asp 
145                 150                 155                 160 


Gly His Lys Asp Trp Ile Phe Ser Ile Ala Trp Ile Ser Asp Thr Met 
                165                 170                 175     


Ala Val Ser Gly Ser Arg Asp Gly Ser Met Gly Leu Trp 
            180                 185                 


<210> 8042
<211> 762
<212> PRT
<213> Homo sapiens

<400> 8042
Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr Asp Gln Asp Leu Leu 
1               5                   10                  15      


Leu Met Gln Glu Gly Met Pro Met Arg Lys Val Arg Ser Lys Ser Trp 
            20                  25                  30          


Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp Gly Met Thr Val Trp 
        35                  40                  45              


His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro Ser Phe Ser Ile Ser 
    50                  55                  60                  


Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser Glu Leu Leu Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe Thr Ile Val Phe His 
                85                  90                  95      


Gly Arg Arg Ser Asn Leu Asp Leu Met Ala Asn Ser Val Glu Glu Ala 
            100                 105                 110         


Gln Ile Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser 
        115                 120                 125             


Met Asp His Gln Glu Arg Leu Asp Gln Trp Leu Ser Asp Trp Phe Gln 
    130                 135                 140                 


Arg Gly Asp Lys Asn Gln Asp Gly Lys Met Ser Phe Gln Glu Val Gln 
145                 150                 155                 160 


Arg Leu Leu His Leu Met Asn Val Glu Met Asp Gln Glu Tyr Ala Phe 
                165                 170                 175     


Ser Leu Phe Gln Ala Ala Asp Thr Ser Gln Ser Gly Thr Leu Glu Gly 
            180                 185                 190         


Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Ala Glu Val 
        195                 200                 205             


Gln Glu Leu Phe Glu Ser Phe Ser Ala Asp Gly Gln Lys Leu Thr Leu 
    210                 215                 220                 


Leu Glu Phe Leu Asp Phe Leu Gln Glu Glu Gln Lys Glu Arg Asp Cys 
225                 230                 235                 240 


Thr Ser Glu Leu Ala Leu Glu Leu Ile Asp Arg Tyr Glu Pro Ser Asp 
                245                 250                 255     


Ser Gly Lys Leu Arg His Val Leu Ser Met Asp Gly Phe Leu Ser Tyr 
            260                 265                 270         


Leu Cys Ser Lys Asp Gly Asp Ile Phe Asn Pro Ala Cys Leu Pro Ile 
        275                 280                 285             


Tyr Gln Asp Met Thr Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser 
    290                 295                 300                 


His Asn Thr Tyr Leu Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val 
305                 310                 315                 320 


Glu Gly Tyr Ile Arg Ala Leu Lys Arg Gly Cys Arg Cys Val Glu Val 
                325                 330                 335     


Asp Val Trp Asp Gly Pro Ser Gly Glu Pro Val Val Tyr His Gly His 
            340                 345                 350         


Thr Leu Thr Ser Arg Ile Leu Phe Lys Asp Val Val Ala Thr Val Ala 
        355                 360                 365             


Gln Tyr Ala Phe Gln Thr Ser Asp Tyr Pro Val Ile Leu Ser Leu Glu 
    370                 375                 380                 


Thr His Cys Ser Trp Glu Gln Gln Gln Thr Met Ala Arg His Leu Thr 
385                 390                 395                 400 


Glu Ile Leu Gly Glu Gln Leu Leu Ser Thr Thr Leu Asp Gly Val Leu 
                405                 410                 415     


Pro Thr Gln Leu Pro Ser Pro Glu Glu Leu Arg Arg Lys Ile Leu Val 
            420                 425                 430         


Lys Gly Lys Lys Leu Thr Leu Glu Glu Asp Leu Glu Tyr Glu Glu Glu 
        435                 440                 445             


Glu Ala Glu Pro Glu Leu Glu Glu Ser Glu Leu Ala Leu Glu Ser Gln 
    450                 455                 460                 


Phe Glu Thr Glu Pro Glu Pro Gln Glu Gln Asn Leu Gln Asn Lys Asp 
465                 470                 475                 480 


Lys Lys Lys Lys Ser Lys Pro Ile Leu Cys Pro Ala Leu Ser Ser Leu 
                485                 490                 495     


Val Ile Tyr Leu Lys Ser Val Ser Phe Arg Ser Phe Thr His Ser Lys 
            500                 505                 510         


Glu His Tyr His Phe Tyr Glu Ile Ser Ser Phe Ser Glu Thr Lys Ala 
        515                 520                 525             


Lys Arg Leu Ile Lys Glu Ala Gly Asn Glu Phe Val Gln His Asn Thr 
    530                 535                 540                 


Trp Gln Leu Ser Arg Val Tyr Pro Ser Gly Leu Arg Thr Asp Ser Ser 
545                 550                 555                 560 


Asn Tyr Asn Pro Gln Glu Leu Trp Asn Ala Gly Cys Gln Met Val Ala 
                565                 570                 575     


Met Asn Met Gln Thr Ala Gly Leu Glu Met Asp Ile Cys Asp Gly His 
            580                 585                 590         


Phe Arg Gln Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro Asp Phe Leu 
        595                 600                 605             


Arg Asp Ile Gln Ser Ser Phe His Pro Glu Lys Pro Ile Ser Pro Phe 
    610                 615                 620                 


Lys Ala Gln Thr Leu Leu Ile Gln Val Ile Ser Gly Gln Gln Leu Pro 
625                 630                 635                 640 


Lys Val Asp Lys Thr Lys Glu Gly Ser Ile Val Asp Pro Leu Val Lys 
                645                 650                 655     


Val Gln Ile Phe Gly Val Arg Leu Asp Thr Ala Arg Gln Glu Thr Asn 
            660                 665                 670         


Tyr Val Glu Asn Asn Gly Phe Asn Pro Tyr Trp Gly Gln Thr Leu Cys 
        675                 680                 685             


Phe Arg Val Leu Val Pro Glu Leu Ala Met Leu Arg Phe Val Val Met 
    690                 695                 700                 


Asp Tyr Asp Trp Lys Ser Arg Asn Asp Phe Ile Gly Gln Tyr Thr Leu 
705                 710                 715                 720 


Pro Trp Thr Cys Met Gln Gln Gly Tyr Arg His Ile His Leu Leu Ser 
                725                 730                 735     


Lys Asp Gly Ile Ser Leu Arg Pro Ala Ser Ile Phe Val Tyr Ile Cys 
            740                 745                 750         


Ile Gln Glu Gly Leu Glu Gly Asp Glu Ser 
        755                 760         


<210> 8043
<211> 453
<212> PRT
<213> Homo sapiens

<400> 8043
Met Ala Gly Ala Ala Gly Arg Val Gln Asp Arg Ala Leu Arg Arg Phe 
1               5                   10                  15      


Pro Ile Thr Leu Pro Val Gly Asp Leu Ser Asn Leu His Leu Lys Glu 
            20                  25                  30          


Glu Lys Ile Lys Pro Asp Thr Asn Gly Ala Val Val Lys Thr Asn Ala 
        35                  40                  45              


Asn Ala Glu Lys Thr Asp Glu Glu Glu Lys Glu Asp Arg Ala Ala Gln 
    50                  55                  60                  


Ser Leu Leu Asn Lys Leu Ile Arg Ser Asn Leu Val Asp Asn Thr Asn 
65                  70                  75                  80  


Gln Val Glu Val Leu Gln Arg Asp Pro Asn Ser Pro Leu Tyr Ser Val 
                85                  90                  95      


Lys Ser Phe Glu Glu Leu Arg Leu Pro Gln Asn Leu Ile Ala Gln Ser 
            100                 105                 110         


Gln Ser Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser 
        115                 120                 125             


Gln Val Glu Pro Ala Asn Lys Tyr Pro Gln Cys Leu Cys Leu Ser Pro 
    130                 135                 140                 


Thr Tyr Glu Leu Ala Leu Gln Thr Gly Lys Val Ile Glu Gln Met Gly 
145                 150                 155                 160 


Lys Phe Tyr Pro Glu Leu Lys Leu Ala Tyr Ala Val Arg Gly Asn Lys 
                165                 170                 175     


Leu Glu Arg Gly Gln Lys Ile Ser Glu Gln Ile Val Ile Gly Thr Pro 
            180                 185                 190         


Gly Thr Val Leu Asp Trp Cys Ser Lys Leu Lys Phe Ile Asp Pro Lys 
        195                 200                 205             


Lys Ile Lys Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Ala Thr 
    210                 215                 220                 


Gln Gly His Gln Asp Gln Ser Ile Arg Ile Gln Arg Met Leu Pro Arg 
225                 230                 235                 240 


Asn Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp 
                245                 250                 255     


Lys Phe Ala Gln Lys Val Val Pro Asp Pro Asn Val Ile Lys Leu Lys 
            260                 265                 270         


Arg Glu Glu Glu Thr Leu Asp Thr Ile Lys Gln Tyr Tyr Val Leu Cys 
        275                 280                 285             


Ser Ser Arg Asp Glu Lys Phe Gln Ala Leu Cys Asn Leu Tyr Gly Ala 
    290                 295                 300                 


Ile Thr Ile Ala Gln Ala Met Ile Phe Cys His Thr Arg Lys Thr Ala 
305                 310                 315                 320 


Ser Trp Leu Ala Ala Glu Leu Ser Lys Glu Gly His Gln Val Ala Leu 
                325                 330                 335     


Leu Ser Gly Glu Met Met Val Glu Gln Arg Ala Ala Val Ile Glu Arg 
            340                 345                 350         


Phe Arg Glu Gly Lys Glu Lys Val Leu Val Thr Thr Asn Val Cys Ala 
        355                 360                 365             


Arg Gly Ile Asp Val Glu Gln Val Ser Val Val Ile Asn Phe Asp Leu 
    370                 375                 380                 


Pro Val Asp Lys Asp Gly Asn Pro Asp Asn Glu Thr Tyr Leu His Arg 
385                 390                 395                 400 


Ile Gly Arg Thr Gly Arg Phe Gly Lys Arg Gly Leu Ala Val Asn Met 
                405                 410                 415     


Val Asp Ser Lys His Ser Met Asn Ile Leu Asn Arg Ile Gln Glu His 
            420                 425                 430         


Phe Asn Lys Lys Ile Glu Arg Leu Asp Thr Asp Asp Leu Asp Glu Ile 
        435                 440                 445             


Glu Lys Ile Ala Asn 
    450             


<210> 8044
<211> 306
<212> PRT
<213> Homo sapiens

<400> 8044
Met Ala Arg Val Pro Leu Gly Arg Ser Leu Thr Leu Ser Pro Arg Leu 
1               5                   10                  15      


Glu His Asn Gly Met Thr Ser Ala His His Asn Phe Arg Leu Pro Gly 
            20                  25                  30          


Ser Arg Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Glu Ile Ile Asp 
        35                  40                  45              


Leu Glu Trp Tyr Glu Lys Ser Glu Glu Thr His Ala Ser Gln Ile Glu 
    50                  55                  60                  


Leu Leu Glu Thr Ser Ser Thr Gln Glu Pro Leu Asn Ala Ser Glu Ala 
65                  70                  75                  80  


Phe Cys Pro Arg Asp Cys Met Val Pro Val Val Phe Pro Gly Pro Val 
                85                  90                  95      


Ser Gln Glu Gly Cys Cys Gln Phe Thr Cys Glu Leu Leu Lys His Ile 
            100                 105                 110         


Met Tyr Gln Arg Gln Gln Leu Pro Leu Pro Tyr Glu Gln Leu Lys His 
        115                 120                 125             


Phe Tyr Arg Lys Pro Ser Pro Gln Ala Glu Glu Met Leu Lys Lys Lys 
    130                 135                 140                 


Pro Arg Ala Thr Thr Glu Val Ser Ser Arg Lys Cys Gln Gln Ala Leu 
145                 150                 155                 160 


Ala Glu Leu Glu Ser Val Leu Ser His Leu Glu Asp Phe Phe Ala Arg 
                165                 170                 175     


Thr Leu Val Pro Arg Val Leu Ile Leu Leu Gly Gly Asn Ala Leu Ser 
            180                 185                 190         


Pro Lys Glu Phe Tyr Glu Leu Asp Leu Ser Leu Leu Ala Pro Tyr Ser 
        195                 200                 205             


Val Asp Gln Ser Leu Ser Thr Ala Ala Cys Leu Arg Arg Leu Phe Arg 
    210                 215                 220                 


Ala Ile Phe Met Ala Asp Ala Phe Ser Glu Leu Gln Ala Pro Pro Leu 
225                 230                 235                 240 


Met Gly Thr Val Val Met Ala Gln Gly His Arg Asn Cys Gly Glu Asp 
                245                 250                 255     


Trp Phe Arg Pro Lys Leu Asn Tyr Arg Val Pro Ser Arg Gly His Lys 
            260                 265                 270         


Leu Thr Val Thr Leu Ser Cys Gly Arg Pro Ser Ile Arg Thr Thr Ala 
        275                 280                 285             


Trp Glu Asp Tyr Ile Trp Phe Gln Ala Pro Val Thr Phe Lys Gly Phe 
    290                 295                 300                 


Arg Glu 
305     


<210> 8045
<211> 141
<212> PRT
<213> Homo sapiens

<400> 8045
Met Pro Gln Leu Leu Gln Asn Ile Asn Gly Ile Ile Glu Ala Phe Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Thr Glu Gly Asn Cys Thr Ala Leu Thr Arg Gly Glu 
            20                  25                  30          


Leu Lys Arg Leu Leu Glu Gln Glu Phe Ala Asp Val Ile Val Lys Pro 
        35                  40                  45              


His Asp Pro Ala Thr Val Asp Glu Val Leu Arg Leu Leu Asp Glu Asp 
    50                  55                  60                  


His Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
65                  70                  75                  80  


Val Ala Gln Ala Cys Phe Lys Thr Leu Ser Glu Ser Ala Glu Gly Ala 
                85                  90                  95      


Cys Gly Ser Gln Glu Ser Gly Ser Leu His Ser Gly Ala Ser Gln Glu 
            100                 105                 110         


Leu Gly Phe Arg Pro Arg Val Arg Pro Leu Ala Leu Arg Gly Ser Ala 
        115                 120                 125             


Ala Met Thr Gly Lys Leu Ser Pro Arg Ala Arg Lys Glu 
    130                 135                 140     


<210> 8046
<211> 159
<212> PRT
<213> Homo sapiens

<400> 8046
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Glu Lys Ile Leu Asn His Leu Ser Thr 
65                  70                  75                  80  


Leu Arg Arg Asp Arg Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu 
                85                  90                  95      


Ala Asp Ile Leu Ala Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr 
            100                 105                 110         


Ile Val Ala Glu Phe Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu 
        115                 120                 125             


Glu His Leu Leu Glu Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu 
    130                 135                 140                 


Gly Arg Glu Lys Phe Lys Ser Arg Gly Val Gly Glu Leu Ala Arg 
145                 150                 155                 


<210> 8047
<211> 501
<212> PRT
<213> Homo sapiens

<400> 8047
Met Asp Phe Leu Leu Gly Asn Pro Phe Ser Ser Pro Val Gly Gln Arg 
1               5                   10                  15      


Ile Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Ala Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe 
    50                  55                  60                  


His Glu Val Met Leu Ala His Ser Ala Arg Arg His Leu Ser Ala Leu 
65                  70                  75                  80  


Gln Val Leu Glu Thr Cys Val Lys Asn Cys Gly His Arg Phe His Val 
                85                  90                  95      


Leu Val Ala Ser Gln Asp Phe Val Glu Ser Val Leu Val Arg Thr Ile 
            100                 105                 110         


Leu Pro Lys Asn Asn Pro Pro Thr Ile Val His Asp Lys Val Leu Asn 
        115                 120                 125             


Leu Ile Gln Ser Trp Ala Asp Ala Phe Arg Ser Ser Pro Asp Leu Thr 
    130                 135                 140                 


Gly Val Val Thr Ile Tyr Glu Asp Leu Arg Arg Lys Gly Leu Glu Phe 
145                 150                 155                 160 


Pro Met Thr Asp Leu Asp Met Leu Ser Pro Ile His Thr Pro Gln Arg 
                165                 170                 175     


Thr Val Phe Asn Ser Glu Thr Gln Ser Gly Gln Asp Ser Val Gly Thr 
            180                 185                 190         


Asp Ser Ser Gln Gln Glu Asp Ser Gly Gln His Ala Ala Pro Leu Pro 
        195                 200                 205             


Ala Pro Pro Ile Leu Ser Gly Asp Thr Pro Ile Ala Pro Thr Pro Glu 
    210                 215                 220                 


Gln Ile Gly Lys Leu Arg Ser Glu Leu Glu Met Val Ser Gly Asn Val 
225                 230                 235                 240 


Arg Val Met Ser Glu Met Leu Thr Glu Leu Val Pro Thr Gln Ala Glu 
                245                 250                 255     


Pro Ala Asp Leu Glu Leu Leu Gln Glu Leu Asn Arg Thr Cys Arg Ala 
            260                 265                 270         


Met Gln Gln Arg Val Leu Glu Leu Ile Pro Gln Ile Ala Asn Glu Gln 
        275                 280                 285             


Leu Thr Glu Glu Leu Leu Ile Val Asn Asp Asn Leu Asn Asn Val Phe 
    290                 295                 300                 


Leu Arg His Glu Arg Phe Glu Arg Phe Arg Thr Gly Gln Thr Thr Lys 
305                 310                 315                 320 


Ala Pro Ser Glu Ala Glu Pro Ala Ala Asp Leu Ile Asp Met Gly Pro 
                325                 330                 335     


Asp Pro Ala Ala Thr Gly Asn Leu Ser Ser Gln Leu Ala Gly Met Asn 
            340                 345                 350         


Leu Gly Ser Ser Ser Val Arg Ala Gly Leu Gln Ser Leu Glu Ala Ser 
        355                 360                 365             


Gly Arg Leu Glu Asp Glu Phe Asp Met Phe Ala Leu Thr Arg Gly Ser 
    370                 375                 380                 


Ser Leu Ala Asp Gln Arg Lys Glu Val Lys Tyr Glu Ala Pro Gln Ala 
385                 390                 395                 400 


Thr Asp Gly Leu Ala Gly Ala Leu Asp Ala Arg Gln Gln Ser Thr Gly 
                405                 410                 415     


Ala Ile Pro Val Thr Gln Ala Cys Leu Met Glu Asp Ile Glu Gln Trp 
            420                 425                 430         


Leu Ser Thr Asp Val Gly Asn Asp Ala Glu Glu Pro Lys Gly Val Thr 
        435                 440                 445             


Ser Glu Glu Phe Asp Lys Phe Leu Glu Glu Arg Ala Lys Ala Ala Asp 
    450                 455                 460                 


Arg Leu Pro Asn Leu Ser Ser Pro Ser Ala Glu Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Pro Ser Gly Pro Ala Pro Arg Lys Lys Thr Gln Glu Lys Asp Asp Asp 
                485                 490                 495     


Met Leu Phe Ala Leu 
            500     


<210> 8048
<211> 38
<212> PRT
<213> Homo sapiens

<400> 8048
Glu Pro Val Tyr Phe Ala Glu Lys Val Met Ser Leu Gly Arg Asn Trp 
1               5                   10                  15      


His Arg Pro Cys Leu Arg Cys Gln Arg Cys His Lys Thr Leu Thr Ala 
            20                  25                  30          


Gly Ser His Ala Glu Val 
        35              


<210> 8049
<211> 373
<212> PRT
<213> Homo sapiens

<400> 8049
Met Ala Gln Glu Ser Pro Lys Asn Ser Ala Ala Glu Ile Pro Val Thr 
1               5                   10                  15      


Ser Asn Gly Glu Val Asp Asp Ser Arg Glu His Ser Phe Asn Arg Asp 
            20                  25                  30          


Leu Lys His Ser Leu Pro Ser Gly Leu Gly Leu Ser Glu Thr Gln Ile 
        35                  40                  45              


Thr Ser His Gly Phe Asp Asn Thr Lys Glu Gly Val Ile Glu Ala Gly 
    50                  55                  60                  


Ala Phe Gln Gly Ser Pro Ala Pro Pro Leu Pro Ser Val Met Ser Pro 
65                  70                  75                  80  


Ser Arg Val Ala Ala Ser Arg Leu Ala Gln Gln Gly Ser Asp Leu Ile 
                85                  90                  95      


Val Pro Ala Gly Gly Gln Arg Thr Gln Thr Lys Ser Gly Pro Val Ile 
            100                 105                 110         


Leu Ala Asp Glu Ile Lys Asn Pro Ala Met Glu Lys Leu Glu Leu Val 
        115                 120                 125             


Arg Lys Trp Ser Leu Asn Thr Tyr Lys Cys Thr Arg Gln Ile Ile Ser 
    130                 135                 140                 


Glu Lys Leu Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Ala 
145                 150                 155                 160 


Gln Ile Asp Ile Leu Arg Asp Asn Lys Lys Lys Tyr Glu Asn Ile Leu 
                165                 170                 175     


Lys Leu Ala Gln Thr Leu Ser Thr Gln Leu Phe Gln Met Val His Thr 
            180                 185                 190         


Gln Arg Gln Leu Gly Asp Ala Phe Ala Asp Leu Ser Leu Lys Ser Leu 
        195                 200                 205             


Glu Leu His Glu Glu Phe Gly Tyr Asn Ala Asp Thr Gln Lys Leu Leu 
    210                 215                 220                 


Ala Lys Asn Gly Glu Thr Leu Leu Gly Ala Ile Asn Phe Phe Ile Ala 
225                 230                 235                 240 


Ser Val Asn Thr Leu Val Asn Lys Thr Ile Glu Asp Thr Leu Met Thr 
                245                 250                 255     


Val Lys Gln Tyr Glu Ser Ala Arg Ile Glu Tyr Asp Ala Tyr Arg Thr 
            260                 265                 270         


Asp Leu Glu Glu Leu Asn Leu Gly Pro Arg Asp Ala Asn Thr Leu Pro 
        275                 280                 285             


Lys Ile Glu Gln Ser Gln His Leu Phe Gln Ala His Lys Glu Lys Tyr 
    290                 295                 300                 


Asp Lys Met Arg Asn Asp Val Ser Val Lys Leu Lys Phe Leu Glu Glu 
305                 310                 315                 320 


Asn Lys Val Lys Val Leu His Asn Gln Leu Val Leu Phe His Asn Ala 
                325                 330                 335     


Ile Ala Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
            340                 345                 350         


Lys Gln Phe His Ile Lys Leu Lys Thr Pro Gly Val Asp Ala Pro Ser 
        355                 360                 365             


Trp Leu Glu Glu Gln 
    370             


<210> 8050
<211> 150
<212> PRT
<213> Homo sapiens

<400> 8050
Met His Thr Gly Asp Pro Lys Gln Asp Leu Ala Tyr Glu Arg Gln Tyr 
1               5                   10                  15      


Glu Gln Gln Thr Tyr Gln Val Ile Pro Glu Val Ile Lys Asn Phe Ile 
            20                  25                  30          


Gln Tyr Phe His Lys Thr Val Ser Asp Leu Ile Asp Gln Lys Val Tyr 
        35                  40                  45              


Glu Leu Gln Ala Ser Arg Val Ser Ser Asp Val Ile Asp Gln Lys Val 
    50                  55                  60                  


Tyr Glu Ile Gln Asp Ile Tyr Glu Asn Ser Trp Thr Lys Leu Thr Glu 
65                  70                  75                  80  


Arg Phe Phe Lys Asn Thr Pro Trp Pro Glu Ala Glu Ala Ile Ala Pro 
                85                  90                  95      


Gln Val Gly Asn Asp Ala Val Phe Leu Ile Leu Tyr Lys Glu Leu Tyr 
            100                 105                 110         


Tyr Arg His Ile Tyr Ala Lys Val Ser Gly Gly Pro Ser Leu Glu Gln 
        115                 120                 125             


Arg Phe Glu Ser Tyr Tyr Asn Tyr Cys Asn Leu Phe Asn Tyr Ile Leu 
    130                 135                 140                 


Asn Ala Asp Gly Pro Ala 
145                 150 


<210> 8051
<211> 711
<212> PRT
<213> Homo sapiens

<400> 8051
Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile Ser His Val Thr 
1               5                   10                  15      


Ser Pro Asn Phe Cys Ser Ser Ser Gly Ser Pro Pro Phe Gln Pro Ile 
            20                  25                  30          


Lys Ser His Val Thr Ile Pro Thr Ala His Val Met Pro Ser Thr Leu 
        35                  40                  45              


Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro Val Gly Pro Ser Ser 
    50                  55                  60                  


Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser Val Gly Met Thr Arg 
65                  70                  75                  80  


Asn Gly Asp Leu Gly Ala Met Lys His Ser Pro Gly Leu Ser Arg Asp 
                85                  90                  95      


Leu Met Tyr Phe Ser Gly Ala Thr Gly Glu Asn Gly Ile Glu Gln Ser 
            100                 105                 110         


Trp Phe Pro Ala Val Gly His Glu Arg Gln Glu Glu Ala Arg Lys Phe 
        115                 120                 125             


Asp Ile Pro Ser Met Glu Ser Thr Leu Asn Gln Ser Ala Met Met Glu 
    130                 135                 140                 


Thr Leu Tyr Ser Asp Pro His His Arg Val Arg Phe His Asn Pro Arg 
145                 150                 155                 160 


Thr Ser Thr Ser Lys Glu Leu Tyr Arg Val Leu Pro Glu Ala Lys Lys 
                165                 170                 175     


Ala Pro Gly Ser Gly Ala Val Phe Glu Arg Asn Gly Pro His Ser Asn 
            180                 185                 190         


Ser Ser Gly Val Leu Pro Leu Gly Leu Gln Pro Ala Pro Gly Leu Ser 
        195                 200                 205             


Lys Pro Leu Pro Ser Gln Val Trp Gln Pro Ser Pro Asp Thr Trp His 
    210                 215                 220                 


Pro Arg Glu Gln Ser Cys Glu Leu Ser Thr Cys Arg Gln Gln Leu Glu 
225                 230                 235                 240 


Leu Ile Arg Leu Gln Met Glu Gln Met Gln Leu Gln Asn Gly Ala Ile 
                245                 250                 255     


Cys His His Pro Ala Ala Phe Gly Pro Ser Leu Pro Ile Leu Glu Pro 
            260                 265                 270         


Ala Gln Trp Ile Ser Ile Leu Asn Ser Asn Glu His Leu Leu Lys Glu 
        275                 280                 285             


Lys Glu Leu Leu Ile Asp Lys Gln Arg Lys His Ile Ser Gln Leu Glu 
    290                 295                 300                 


Gln Lys Val Arg Glu Ser Glu Leu Gln Val His Ser Ala Leu Leu Gly 
305                 310                 315                 320 


Arg Pro Ala Pro Phe Gly Asp Val Cys Leu Leu Arg Leu Gln Glu Leu 
                325                 330                 335     


Gln Arg Glu Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln Lys Thr Glu 
            340                 345                 350         


Ala Leu Ser Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu Ser Ala Ser 
        355                 360                 365             


Glu Val Glu Val Gln Leu Ile Arg Glu Ser Leu Lys Val Ala Leu Gln 
    370                 375                 380                 


Lys His Ser Glu Glu Val Lys Lys Gln Glu Glu Arg Val Lys Gly Arg 
385                 390                 395                 400 


Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys Glu Ser Glu 
                405                 410                 415     


Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu Arg Tyr Leu 
            420                 425                 430         


Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser Gln Gln Leu 
        435                 440                 445             


Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys Val Thr Glu 
    450                 455                 460                 


Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg Glu Lys Glu 
465                 470                 475                 480 


Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe Ser Ser Ala 
                485                 490                 495     


Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr Ser Gly Glu 
            500                 505                 510         


Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser Leu 
        515                 520                 525             


Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln Leu Arg Ser 
    530                 535                 540                 


Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu Gly Thr Ser 
545                 550                 555                 560 


Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala Leu Gln Gln 
                565                 570                 575     


Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln Asp Leu Ile 
            580                 585                 590         


Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala Gln Pro Gly 
        595                 600                 605             


Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu Leu His Gln 
    610                 615                 620                 


Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys Ser Ile Val 
625                 630                 635                 640 


Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu Leu Leu Gly 
                645                 650                 655     


Ile His Ser Ala Gln His Pro Glu Thr Gln Leu Asp Leu Gln Lys Pro 
            660                 665                 670         


Asp Val Ile Lys Arg Lys Leu Glu Glu Val Gln Gln Leu Arg Arg Asp 
        675                 680                 685             


Ile Glu Asp Leu Arg Thr Thr Met Ser Asp Arg Tyr Ala Gln Asp Met 
    690                 695                 700                 


Gly Glu Asn Cys Val Thr Gln 
705                 710     


<210> 8052
<211> 176
<212> PRT
<213> Homo sapiens

<400> 8052
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe 
                85                  90                  95      


Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile 
            100                 105                 110         


Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu 
        115                 120                 125             


Asn Lys Phe Leu Leu Leu Thr Phe Ala Asp Leu Lys Lys Tyr His Phe 
    130                 135                 140                 


Tyr Tyr Trp Phe Cys Tyr Pro Ala Leu Cys Leu Pro Glu Ser Leu Pro 
145                 150                 155                 160 


Leu Ile Gln Gly Pro Val Gly Leu Asp Gln Arg Phe Ser Leu Lys Gln 
                165                 170                 175     


<210> 8053
<211> 480
<212> PRT
<213> Homo sapiens

<400> 8053
Met Lys Leu Lys Glu Leu Glu Arg Pro Ala Val Gln Ala Trp Ser Pro 
1               5                   10                  15      


Ala Ser Gln Tyr Pro Leu Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
            20                  25                  30          


Leu Asp Ser Ser Phe Ser Thr Asn Gly Thr Leu Glu Ile Phe Glu Val 
        35                  40                  45              


Asp Phe Arg Asp Pro Ser Leu Asp Leu Lys His Arg Gly Val Leu Ser 
    50                  55                  60                  


Ala Leu Ser Arg Phe His Lys Leu Val Trp Gly Ser Phe Gly Ser Gly 
65                  70                  75                  80  


Leu Leu Glu Ser Ser Gly Val Ile Val Gly Gly Gly Asp Asn Gly Met 
                85                  90                  95      


Leu Ile Leu Tyr Asn Val Thr His Ile Leu Ser Ser Gly Lys Glu Pro 
            100                 105                 110         


Val Ile Ala Gln Lys Gln Lys His Thr Gly Ala Val Arg Ala Leu Asp 
        115                 120                 125             


Leu Asn Pro Phe Gln Gly Asn Leu Leu Ala Ser Gly Ala Ser Asp Ser 
    130                 135                 140                 


Glu Ile Phe Ile Trp Asp Leu Asn Asn Leu Asn Val Pro Met Thr Leu 
145                 150                 155                 160 


Gly Ser Lys Ser Gln Gln Pro Pro Glu Asp Ile Lys Ala Leu Ser Trp 
                165                 170                 175     


Asn Arg Gln Ala Gln His Ile Leu Ser Ser Ala His Pro Ser Gly Lys 
            180                 185                 190         


Ala Val Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile Lys Val Ser 
        195                 200                 205             


Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp His Pro Asp 
    210                 215                 220                 


Ile Ala Thr Gln Leu Val Leu Cys Ser Glu Asp Asp Arg Leu Pro Val 
225                 230                 235                 240 


Ile Gln Leu Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Lys Val Leu 
                245                 250                 255     


Glu Ser His Ser Arg Gly Ile Leu Ser Val Ser Trp Ser Gln Ala Asp 
            260                 265                 270         


Ala Glu Leu Leu Leu Thr Ser Ala Lys Asp Ser Gln Ile Leu Cys Arg 
        275                 280                 285             


Asn Leu Gly Ser Ser Glu Val Val Tyr Lys Leu Pro Thr Gln Ser Ser 
    290                 295                 300                 


Trp Cys Phe Asp Val Gln Trp Cys Pro Arg Asp Pro Ser Val Phe Ser 
305                 310                 315                 320 


Ala Ala Ser Phe Asn Gly Trp Ile Ser Leu Tyr Ser Val Met Gly Arg 
                325                 330                 335     


Ser Trp Glu Val Gln His Met Arg Gln Ala Asp Lys Ile Ser Ser Ser 
            340                 345                 350         


Phe Ser Lys Gly Gln Pro Leu Pro Pro Leu Gln Val Pro Glu Gln Val 
        355                 360                 365             


Ala Gln Ala Pro Leu Ile Pro Pro Leu Lys Lys Pro Pro Lys Trp Ile 
    370                 375                 380                 


Arg Arg Pro Thr Gly Val Ser Phe Ala Phe Gly Gly Lys Leu Val Thr 
385                 390                 395                 400 


Phe Gly Leu Pro Ser Thr Pro Ala His Leu Val Pro Gln Pro Cys Pro 
                405                 410                 415     


Arg Leu Val Phe Ile Ser Gln Val Thr Thr Glu Ser Glu Phe Leu Met 
            420                 425                 430         


Arg Ser Ala Glu Leu Gln Glu Ala Leu Gly Ser Gly Asn Leu Leu Asn 
        435                 440                 445             


Tyr Cys Gln Asn Lys Ser Gln Gln Ala Leu Leu Gln Ser Glu Lys Met 
    450                 455                 460                 


Leu Trp Gln Phe Leu Lys Pro Ala Arg Asp Ser Ser Gly Ala Arg Arg 
465                 470                 475                 480 


<210> 8054
<211> 613
<212> PRT
<213> Homo sapiens

<400> 8054
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 8055
<211> 481
<212> PRT
<213> Homo sapiens

<400> 8055
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 8056
<211> 178
<212> PRT
<213> Homo sapiens

<400> 8056
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Glu Ala Cys Tyr Asn Cys Gly Arg 
65                  70                  75                  80  


Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu 
                85                  90                  95      


Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys 
            100                 105                 110         


Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His 
        115                 120                 125             


Ile Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr 
    130                 135                 140                 


Gly His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr 
145                 150                 155                 160 


Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala 
                165                 170                 175     


Thr Ala 
        


<210> 8057
<211> 28
<212> PRT
<213> Homo sapiens

<400> 8057
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu 
            20                  25              


<210> 8058
<211> 200
<212> PRT
<213> Homo sapiens

<400> 8058
Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Leu Gln Met Ser Ile Met Tyr Ala Leu Cys Phe Arg Tyr 
            180                 185                 190         


Asp Gln Val Leu Glu Thr Ala Gly 
        195                 200 


<210> 8059
<211> 188
<212> PRT
<213> Homo sapiens

<400> 8059
Met Ala Thr Pro Leu Gly Trp Ser Lys Ala Gly Ser Gly Ser Val Cys 
1               5                   10                  15      


Leu Ala Leu Asp Gln Leu Arg Asp Val Ile Glu Ser Gln Glu Glu Leu 
            20                  25                  30          


Ile His Gln Leu Arg Asn Val Met Val Leu Gln Asp Glu Asn Phe Val 
        35                  40                  45              


Ser Lys Glu Glu Phe Gln Ala Val Glu Lys Lys Leu Val Glu Glu Lys 
    50                  55                  60                  


Ala Ala His Ala Lys Thr Lys Val Leu Leu Ala Lys Glu Glu Glu Lys 
65                  70                  75                  80  


Leu Gln Phe Ala Leu Gly Glu Val Glu Val Leu Ser Lys Gln Leu Glu 
                85                  90                  95      


Lys Glu Lys Leu Ala Phe Glu Lys Ala Leu Ser Ser Val Lys Ser Lys 
            100                 105                 110         


Val Leu Gln Glu Ser Ser Lys Lys Asp Gln Leu Ile Thr Lys Cys Asn 
        115                 120                 125             


Gly Arg Arg Glu Ala Arg Ala Leu His His Gly Tyr Ile Asn Gly Leu 
    130                 135                 140                 


Phe Pro Asn His Pro Val Pro Val Ser Lys Ala Gly Phe His Ser Asn 
145                 150                 155                 160 


Thr Cys Pro Gln Leu Arg Ile Gln Ala Gly Pro Gly Gly Pro His Leu 
                165                 170                 175     


Arg Lys Gly Leu Lys Gly Pro Gly Arg Pro Arg Lys 
            180                 185             


<210> 8060
<211> 126
<212> PRT
<213> Homo sapiens

<400> 8060
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val 
1               5                   10                  15      


Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val 
            20                  25                  30          


Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser 
        35                  40                  45              


Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile 
    50                  55                  60                  


Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser 
65                  70                  75                  80  


Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala 
                85                  90                  95      


Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn 
            100                 105                 110         


Ile Leu Arg Cys Arg Ser Met Asn Gln Asn Phe Ser Pro Asn 
        115                 120                 125     


<210> 8061
<211> 480
<212> PRT
<213> Homo sapiens

<400> 8061
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Met Val Pro Gly Lys Glu Gly Gly 
            260                 265                 270         


Val Pro Leu Ala Pro Asn Gln Pro Val His Gly Thr Gln Ala Asp Gln 
        275                 280                 285             


Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg Thr His Cys Ala Ala 
    290                 295                 300                 


Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val Ser Asn Ser Ser Glu 
305                 310                 315                 320 


Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr Ile Phe Val Arg Lys 
                325                 330                 335     


Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln Val Thr Leu Thr Ser 
            340                 345                 350         


Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys Asn Leu Glu Leu Glu 
        355                 360                 365             


Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser Pro Glu Thr Glu Ser 
    370                 375                 380                 


Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asn Thr His Asp Asp Phe Val Met Ile Asp Phe Lys Pro Ala Phe 
                405                 410                 415     


Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly Thr Phe Tyr Arg Glu 
            420                 425                 430         


Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser Ile Asp Ile Gly Ala 
        435                 440                 445             


Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro Glu Lys Leu Ala Val 
    450                 455                 460                 


His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe Val Glu Thr Leu Gln 
465                 470                 475                 480 


<210> 8062
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8062
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 8063
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8063
Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu 
        115 


<210> 8064
<211> 133
<212> PRT
<213> Homo sapiens

<400> 8064
Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met Glu 
    130             


<210> 8065
<211> 87
<212> PRT
<213> Homo sapiens

<400> 8065
Met Ser Leu Phe Gly Thr Thr Ser Gly Phe Gly Thr Ser Gly Thr Ser 
1               5                   10                  15      


Met Phe Gly Ser Ala Thr Thr Asp Asn His Asn Pro Met Lys Asp Ile 
            20                  25                  30          


Glu Val Thr Ser Ser Pro Asp Asp Ser Ile Gly Cys Leu Ser Phe Ser 
        35                  40                  45              


Pro Pro Thr Leu Pro Gly Asn Phe Leu Ile Ala Gly Ser Trp Ala Asn 
    50                  55                  60                  


Asp Val Arg Cys Trp Glu Val Gln Asp Ser Gly Gln Thr Ile Pro Lys 
65                  70                  75                  80  


Ala Gln Gln Met His Thr Gly 
                85          


<210> 8066
<211> 442
<212> PRT
<213> Homo sapiens

<400> 8066
Met Ala Asn Ser Phe Ala Ala Arg Ile Phe Thr Thr Leu Ser Asp Leu 
1               5                   10                  15      


Gln Thr Asn Met Ala Asn Leu Lys Val Ile Gly Ile Val Ile Gly Lys 
            20                  25                  30          


Thr Asp Val Lys Gly Phe Pro Asp Arg Lys Ser Ile Gly Ser Glu Arg 
        35                  40                  45              


Tyr Thr Phe Ser Phe Thr Ile Arg Asp Ser Pro Ala His Phe Val Asn 
    50                  55                  60                  


Ala Ala Ser Trp Gly Asn Glu Asp Tyr Ile Lys Ser Leu Ser Asp Ser 
65                  70                  75                  80  


Phe Arg Val Gly Asp Cys Val Ile Ile Glu Asn Pro Leu Ile Gln Arg 
                85                  90                  95      


Lys Glu Ile Glu Arg Glu Glu Lys Phe Ser Pro Ala Thr Pro Ser Asn 
            100                 105                 110         


Cys Lys Leu Leu Leu Ser Glu Asn His Ser Thr Val Lys Val Cys Ser 
        115                 120                 125             


Ser Tyr Glu Val Asp Thr Lys Leu Leu Ser Leu Ile His Leu Pro Val 
    130                 135                 140                 


Lys Glu Ser His Asp Tyr Tyr Ser Leu Gly Asp Ile Val Ala Asn Gly 
145                 150                 155                 160 


His Ser Leu Asn Gly Arg Ile Ile Asn Val Leu Ala Ala Val Lys Ser 
                165                 170                 175     


Val Gly Glu Pro Lys Tyr Phe Thr Thr Ser Asp Arg Arg Lys Gly Gln 
            180                 185                 190         


Arg Cys Glu Val Arg Leu Tyr Asp Glu Thr Glu Ser Ser Phe Ala Met 
        195                 200                 205             


Thr Cys Trp Asp Asn Glu Ser Ile Leu Leu Ala Gln Ser Trp Met Pro 
    210                 215                 220                 


Arg Glu Thr Val Ile Phe Ala Ser Asp Val Arg Ile Asn Phe Asp Lys 
225                 230                 235                 240 


Phe Arg Asn Cys Met Thr Ala Thr Val Ile Ser Lys Thr Ile Ile Thr 
                245                 250                 255     


Thr Asn Pro Asp Ile Pro Glu Ala Asn Ile Leu Leu Asn Phe Ile Arg 
            260                 265                 270         


Glu Asn Lys Glu Thr Asn Val Leu Asp Asp Glu Ile Asp Ser Tyr Phe 
        275                 280                 285             


Lys Glu Ser Ile Asn Leu Ser Thr Ile Val Asp Val Tyr Thr Val Glu 
    290                 295                 300                 


Gln Leu Lys Gly Lys Ala Leu Lys Asn Glu Gly Lys Ala Asp Pro Ser 
305                 310                 315                 320 


Tyr Gly Ile Leu Tyr Ala Tyr Ile Ser Thr Leu Asn Ile Asp Asp Glu 
                325                 330                 335     


Thr Thr Lys Val Val Arg Asn Arg Cys Ser Ser Cys Gly Tyr Ile Val 
            340                 345                 350         


Asn Glu Ala Ser Asn Met Cys Thr Thr Cys Asn Lys Asn Ser Leu Asp 
        355                 360                 365             


Phe Lys Ser Val Phe Leu Ser Phe His Val Leu Ile Asp Leu Thr Asp 
    370                 375                 380                 


His Thr Gly Thr Leu His Ser Cys Ser Leu Thr Gly Ser Val Ala Glu 
385                 390                 395                 400 


Glu Thr Leu Gly Cys Thr Phe Val Leu Ser His Arg Ala Arg Ser Gly 
                405                 410                 415     


Leu Lys Ile Ser Val Leu Ser Cys Lys Leu Ala Asp Pro Thr Glu Ala 
            420                 425                 430         


Ser Arg Asn Leu Ser Gly Gln Lys His Val 
        435                 440         


<210> 8067
<211> 216
<212> PRT
<213> Homo sapiens

<400> 8067
Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe 
1               5                   10                  15      


Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe 
            20                  25                  30          


Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu 
        35                  40                  45              


Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg 
    50                  55                  60                  


Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu 
65                  70                  75                  80  


Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys 
                85                  90                  95      


Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln 
            100                 105                 110         


Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe 
        115                 120                 125             


Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu 
    130                 135                 140                 


Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn 
145                 150                 155                 160 


Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu 
                165                 170                 175     


Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser 
            180                 185                 190         


Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys 
        195                 200                 205             


Val Ser Met Asp Asn Arg Leu Met 
    210                 215     


<210> 8068
<211> 142
<212> PRT
<213> Homo sapiens

<400> 8068
Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210> 8069
<211> 148
<212> PRT
<213> Homo sapiens

<400> 8069
Ala Ile His Ile Leu Asp Val Leu Val Leu Asn Gly Thr Asp Val Arg 
1               5                   10                  15      


Glu Gln His Phe Asn Gln Arg Ile Gln Leu Ala Glu Lys Phe Val Lys 
            20                  25                  30          


Ala Val Ser Lys Pro Ser Arg Pro Asp Met Asn Pro Ile Arg Val Lys 
        35                  40                  45              


Glu Val Tyr Arg Leu Glu Glu Met Glu Lys Ile Phe Val Arg Leu Glu 
    50                  55                  60                  


Met Lys Ile Ile Lys Gly Ser Ser Gly Thr Pro Lys Leu Ser Tyr Thr 
65                  70                  75                  80  


Gly Arg Asp Asp Arg His Phe Val Pro Met Gly Leu Tyr Ile Val Arg 
                85                  90                  95      


Thr Val Asn Glu Pro Trp Thr Met Gly Phe Ser Lys Ser Phe Lys Lys 
            100                 105                 110         


Lys Phe Phe Tyr Asn Lys Lys Thr Lys Asp Ser Thr Phe Asp Leu Pro 
        115                 120                 125             


Tyr Tyr Pro Phe Pro Ser Phe Phe Phe Pro Asn Arg Arg Tyr Asn Leu 
    130                 135                 140                 


Leu Leu Phe Val 
145             


<210> 8070
<211> 99
<212> PRT
<213> Homo sapiens

<400> 8070
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Ile Leu 
        35                  40                  45              


Leu Arg Leu Pro Thr Thr Arg Ile His Ser Val Asn Ser Cys Pro Ala 
    50                  55                  60                  


Leu Ser His Thr Gln Ala Ser Ala Phe Ser Gly Glu Thr Leu Ala Val 
65                  70                  75                  80  


Leu Thr Ala Gly Ile Ser Lys Arg Trp Pro Lys Tyr Arg Leu Pro Ile 
                85                  90                  95      


Asp Ile Ala 
            


<210> 8071
<211> 830
<212> PRT
<213> Homo sapiens

<400> 8071
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Pro Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro 
            100                 105                 110         


Glu Leu Gly Tyr Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg 
        115                 120                 125             


Tyr Asp Leu Asn Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu 
    130                 135                 140                 


Glu Phe Lys Glu Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu 
145                 150                 155                 160 


Arg Val Leu Glu Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His 
                165                 170                 175     


Ala Ile Glu Thr Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val 
            180                 185                 190         


Val Cys Asp Val Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met 
        195                 200                 205             


Val Phe Cys Asp Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly 
    210                 215                 220                 


Ile Leu Lys Val Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu 
225                 230                 235                 240 


Gly Val Gln Pro Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met 
                245                 250                 255     


Lys Pro Thr Arg Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu 
            260                 265                 270         


Trp Ile Pro Glu Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile 
        275                 280                 285             


Thr Lys Val Ser His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser 
    290                 295                 300                 


Leu Cys Asn Glu Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn 
305                 310                 315                 320 


Cys Arg Thr Ala Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu 
                325                 330                 335     


Met Lys Thr Ile Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr 
            340                 345                 350         


Cys Pro Lys His Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys 
        355                 360                 365             


Gly Ala Ala Gln Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro 
    370                 375                 380                 


Leu Glu Pro Phe Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg 
385                 390                 395                 400 


Val Ser Val Arg Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr 
                405                 410                 415     


Thr Phe Val Asn Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu 
            420                 425                 430         


Glu Val Val Asp Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val 
        435                 440                 445             


Asn Phe Asn Lys Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn 
    450                 455                 460                 


Leu Ala Lys Arg Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe 
465                 470                 475                 480 


Thr His Leu Arg Gln Asp Leu Glu Arg Val Arg Asn Leu Thr Tyr Met 
                485                 490                 495     


Val Thr Arg Arg Glu Lys Ile Lys Arg Ser Val Cys Lys Val Gln Glu 
            500                 505                 510         


Gln Ile Phe Asn Leu Tyr Thr Lys Leu Leu Glu Gln Glu Arg Val Ser 
        515                 520                 525             


Gly Val Pro Ser Ser Cys Ser Ser Ser Ser Leu Glu Asn Met Leu Leu 
    530                 535                 540                 


Phe Asn Ser Pro Ser Val Gly Pro Asp Ala Pro Lys Ile Glu Asp Leu 
545                 550                 555                 560 


Lys Trp His Ser Ala Phe Phe Arg Lys Gln Met Gly Thr Ser Leu Val 
                565                 570                 575     


His Ser Leu Lys Lys Pro His Lys Arg Asp Pro Leu Gln Asn Ser Pro 
            580                 585                 590         


Gly Ser Glu Gly Lys Thr Leu Leu Lys Gln Pro Asp Leu Cys Gly Arg 
        595                 600                 605             


Arg Glu Gly Met Val Val Pro Glu Ser Phe Leu Gly Leu Glu Lys Thr 
    610                 615                 620                 


Phe Ala Glu Ala Arg Leu Ile Ser Ala Gln Gln Lys Asn Gly Val Val 
625                 630                 635                 640 


Met Pro Asp His Gly Lys Arg Arg Asp Asn Arg Phe His Cys Asp Leu 
                645                 650                 655     


Ile Lys Gly Asp Leu Lys Asp Lys Ser Phe Lys Gln Ser His Lys Pro 
            660                 665                 670         


Leu Arg Ser Thr Asp Val Ser Gln Arg His Leu Asp Asn Thr Arg Ala 
        675                 680                 685             


Ala Thr Ser Pro Gly Val Gly Gln Ser Ala Pro Gly Thr Arg Lys Glu 
    690                 695                 700                 


Ile Val Pro Lys Cys Asn Gly Ser Leu Ile Lys Val Asn Tyr Asn Gln 
705                 710                 715                 720 


Thr Ala Val Lys Val Pro Thr Thr Pro Ala Ser Pro Val Lys Asn Trp 
                725                 730                 735     


Gly Gly Phe Arg Ile Pro Lys Lys Gly Glu Arg Gln Gln Gln Gly Glu 
            740                 745                 750         


Ala His Asp Gly Ala Cys His Gln His Ser Asp Tyr Pro Tyr Leu Gly 
        755                 760                 765             


Leu Gly Arg Val Pro Ala Lys Glu Arg Ala Lys Ser Lys Leu Lys Ser 
    770                 775                 780                 


Asp Asn Glu Asn Asp Gly Tyr Val Pro Asp Val Glu Met Ser Asp Ser 
785                 790                 795                 800 


Glu Ser Glu Ala Ser Glu Lys Lys Cys Ile His Thr Ser Ser Thr Ile 
                805                 810                 815     


Ser Arg Arg Thr Asp Ile Ile Arg Arg Ser Ile Leu Ala Ser 
            820                 825                 830 


<210> 8072
<211> 133
<212> PRT
<213> Homo sapiens

<400> 8072
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe 
        35                  40                  45              


Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu 
    50                  55                  60                  


Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys 
65                  70                  75                  80  


Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile 
                85                  90                  95      


Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile Thr Ala Gly Ala 
            100                 105                 110         


Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe Gly Pro Asp Gly 
        115                 120                 125             


Val Gln Gly Phe Glu 
    130             


<210> 8073
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8073
Met Ser Pro Gly Ser Gly Val Lys Ser Glu Tyr Met Lys Arg Tyr Gln 
1               5                   10                  15      


Glu Pro Arg Trp Glu Glu Tyr Gly Pro Cys Tyr Arg Glu Leu Leu His 
            20                  25                  30          


Tyr Arg Leu Gly Arg Arg Leu Leu Glu Gln Ala His Ala Pro Trp Leu 
        35                  40                  45              


Trp Asp Asp Trp Gly Pro Ala Gly Ser Ser Glu Asp Ser Ala Ser Ser 
    50                  55                  60                  


Glu Ser Ser Gly Ala Gly Gly Pro Ala Pro Arg Cys Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Pro Pro Pro Val Glu Pro Ala Thr Gln Glu Glu Ala Glu Arg Arg 
                85                  90                  95      


Ala Arg Gly Ala Pro Glu Glu Gln Asp Ala Glu Ala Gly Asp Ala Glu 
            100                 105                 110         


Ala Glu Asp Ala Glu Asp Ala Ala Leu Pro Gly Asn Ala Trp Leu Arg 
        115                 120                 125             


Thr 
    


<210> 8074
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8074
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 8075
<211> 133
<212> PRT
<213> Homo sapiens

<400> 8075
Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln Leu 
1               5                   10                  15      


Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu Arg 
            20                  25                  30          


Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys Ser 
        35                  40                  45              


Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala Glu 
    50                  55                  60                  


Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His Glu 
65                  70                  75                  80  


Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp Thr 
                85                  90                  95      


Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys Pro 
            100                 105                 110         


Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln Thr 
        115                 120                 125             


Leu Ser Glu Leu Asp 
    130             


<210> 8076
<211> 790
<212> PRT
<213> Homo sapiens

<400> 8076
Met Gly Thr Arg Lys Lys Val His Ala Phe Val Arg Val Lys Pro Thr 
1               5                   10                  15      


Asp Asp Phe Ala His Glu Met Ile Arg Tyr Gly Asp Asp Lys Arg Ser 
            20                  25                  30          


Ile Asp Ile His Leu Lys Lys Asp Ile Arg Arg Gly Val Val Asn Asn 
        35                  40                  45              


Gln Gln Thr Asp Trp Ser Phe Lys Leu Asp Gly Val Leu His Asp Ala 
    50                  55                  60                  


Ser Gln Asp Leu Val Tyr Glu Thr Val Ala Lys Asp Val Val Ser Gln 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Gly Thr Ile Met Cys Tyr Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Lys Thr Tyr Thr Met Met Gly Ala Thr Glu Asn Tyr Lys His 
            100                 105                 110         


Arg Gly Ile Leu Pro Arg Ala Leu Gln Gln Val Phe Arg Met Ile Glu 
        115                 120                 125             


Glu Arg Pro Thr His Ala Ile Thr Val Arg Val Ser Tyr Leu Glu Ile 
    130                 135                 140                 


Tyr Asn Glu Ser Leu Phe Asp Leu Leu Ser Thr Leu Pro Tyr Val Gly 
145                 150                 155                 160 


Pro Ser Val Thr Pro Met Thr Ile Val Glu Asn Pro Gln Gly Val Phe 
                165                 170                 175     


Ile Lys Gly Leu Ser Val His Leu Thr Ser Gln Glu Glu Asp Ala Phe 
            180                 185                 190         


Ser Leu Leu Phe Glu Gly Glu Thr Asn Arg Ile Ile Ala Ser His Thr 
        195                 200                 205             


Met Asn Lys Asn Ser Ser Arg Ser His Cys Ile Phe Thr Ile Tyr Leu 
    210                 215                 220                 


Glu Ala His Ser Arg Thr Leu Ser Glu Glu Lys Tyr Ile Thr Ser Lys 
225                 230                 235                 240 


Ile Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Gly Lys Ser Gly 
                245                 250                 255     


Ser Glu Gly Gln Val Leu Lys Glu Ala Thr Tyr Ile Asn Lys Ser Leu 
            260                 265                 270         


Ser Phe Leu Glu Gln Ala Ile Ile Ala Leu Gly Asp Gln Lys Arg Asp 
        275                 280                 285             


His Ile Pro Phe Arg Gln Cys Lys Leu Thr His Ala Leu Lys Asp Ser 
    290                 295                 300                 


Leu Gly Gly Asn Cys Asn Met Val Leu Val Thr Asn Ile Tyr Gly Glu 
305                 310                 315                 320 


Ala Ala Gln Leu Glu Glu Thr Leu Ser Ser Leu Arg Phe Ala Ser Arg 
                325                 330                 335     


Met Lys Leu Val Thr Thr Glu Pro Ala Ile Asn Glu Lys Tyr Asp Ala 
            340                 345                 350         


Glu Arg Met Val Lys Asn Leu Glu Lys Glu Leu Ala Leu Leu Lys Gln 
        355                 360                 365             


Glu Leu Ala Ile His Asp Ser Leu Thr Asn Arg Thr Phe Val Thr Tyr 
    370                 375                 380                 


Asp Pro Met Asp Glu Ile Gln Ile Ala Glu Ile Asn Ser Gln Val Arg 
385                 390                 395                 400 


Arg Tyr Leu Glu Gly Thr Leu Asp Glu Ile Asp Ile Ile Ser Leu Arg 
                405                 410                 415     


Gln Ile Lys Glu Val Phe Asn Gln Phe Arg Val Val Leu Ser Gln Gln 
            420                 425                 430         


Glu Gln Glu Val Glu Ser Thr Leu Arg Arg Lys Tyr Thr Leu Ile Asp 
        435                 440                 445             


Arg Asn Asp Phe Ala Ala Ile Ser Ala Ile Gln Lys Ala Gly Leu Val 
    450                 455                 460                 


Asp Val Asp Gly His Leu Val Gly Glu Pro Glu Gly Gln Asn Phe Gly 
465                 470                 475                 480 


Leu Gly Val Ala Pro Phe Ser Thr Lys Pro Gly Lys Lys Ala Lys Ser 
                485                 490                 495     


Lys Lys Thr Phe Lys Glu Pro Leu Ser Ser Leu Ala Arg Lys Glu Gly 
            500                 505                 510         


Ala Ser Ser Pro Val Asn Gly Lys Asp Leu Asp Tyr Val Ser Thr Ser 
        515                 520                 525             


Lys Thr Gln Leu Val Pro Ser Ser Lys Asp Gly Asp Val Lys Asp Met 
    530                 535                 540                 


Leu Ser Arg Asp Arg Glu Thr Ser Ser Ile Glu Pro Leu Pro Ser Asp 
545                 550                 555                 560 


Ser Pro Lys Glu Glu Leu Arg Pro Ile Arg Pro Asp Thr Pro Pro Ser 
                565                 570                 575     


Lys Pro Val Ala Phe Glu Glu Phe Lys Asn Glu Gln Gly Ser Glu Ile 
            580                 585                 590         


Asn Arg Ile Phe Lys Glu Asn Lys Ser Ile Leu Asn Glu Arg Arg Lys 
        595                 600                 605             


Arg Ala Ser Glu Thr Thr Gln His Ile Asn Ala Ile Lys Arg Glu Ile 
    610                 615                 620                 


Asp Val Thr Lys Glu Ala Leu Asn Phe Gln Lys Ser Leu Arg Glu Lys 
625                 630                 635                 640 


Gln Gly Lys Tyr Glu Asn Lys Gly Leu Met Ile Ile Asp Glu Glu Glu 
                645                 650                 655     


Phe Leu Leu Ile Leu Lys Leu Lys Asp Leu Lys Lys Gln Tyr Arg Ser 
            660                 665                 670         


Glu Tyr Gln Asp Leu Arg Asp Leu Arg Ala Glu Ile Gln Tyr Cys Gln 
        675                 680                 685             


His Leu Val Asp Gln Cys Arg His Arg Leu Leu Met Glu Phe Asp Ile 
    690                 695                 700                 


Trp Tyr Asn Glu Ser Phe Val Ile Pro Glu Asp Met Gln Met Ala Leu 
705                 710                 715                 720 


Lys Pro Gly Gly Ser Ile Arg Pro Gly Met Val Pro Val Asn Arg Ile 
                725                 730                 735     


Val Ser Leu Gly Glu Asp Asp Gln Asp Lys Phe Ser Gln Leu Gln Gln 
            740                 745                 750         


Arg Val Leu Pro Glu Gly Pro Asp Ser Ile Ser Phe Tyr Asn Ala Lys 
        755                 760                 765             


Val Lys Ile Glu Gln Lys His Asn Tyr Leu Lys Thr Met Met Gly Leu 
    770                 775                 780                 


Gln Gln Ala His Arg Lys 
785                 790 


<210> 8077
<211> 451
<212> PRT
<213> Homo sapiens

<400> 8077
Met Tyr Gly Ala Pro Gly Ala Pro Ala Gln Ser Ala Ser Val Thr Val 
1               5                   10                  15      


Val Arg Ser Leu Arg Arg Pro Pro Pro Gln Ala Thr Gly Val Ser Phe 
            20                  25                  30          


Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe 
        35                  40                  45              


Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe 
    50                  55                  60                  


Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu 
65                  70                  75                  80  


Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg 
                85                  90                  95      


Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu 
            100                 105                 110         


Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys 
        115                 120                 125             


Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln 
    130                 135                 140                 


Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe 
145                 150                 155                 160 


Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu 
                165                 170                 175     


Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn 
            180                 185                 190         


Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu 
        195                 200                 205             


Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser 
    210                 215                 220                 


Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys 
225                 230                 235                 240 


Val Ser Met Asp Asn Arg Leu Met Glu Leu Phe Pro Ala Asn Lys Gln 
                245                 250                 255     


Ser Val Glu His Phe Thr Lys Tyr Phe Thr Glu Ala Gly Leu Lys Glu 
            260                 265                 270         


Leu Ser Glu Tyr Val Arg Asn Gln Gln Thr Ile Gly Ala Arg Lys Glu 
        275                 280                 285             


Leu Gln Lys Glu Leu Gln Glu Gln Met Ser Arg Gly Asp Pro Phe Lys 
    290                 295                 300                 


Asp Ile Ile Leu Tyr Val Lys Glu Glu Met Lys Lys Asn Asn Ile Pro 
305                 310                 315                 320 


Glu Pro Val Val Ile Gly Ile Val Trp Ser Ser Val Met Ser Thr Val 
                325                 330                 335     


Glu Trp Asn Lys Lys Glu Glu Leu Val Ala Glu Gln Ala Ile Lys His 
            340                 345                 350         


Leu Lys Gln Tyr Ser Pro Leu Leu Ala Ala Phe Thr Thr Gln Gly Gln 
        355                 360                 365             


Ser Glu Leu Thr Leu Leu Leu Lys Ile Gln Glu Tyr Cys Tyr Asp Asn 
    370                 375                 380                 


Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val Leu Phe Tyr Lys 
385                 390                 395                 400 


Ala Glu Val Leu Ser Glu Glu Pro Ile Leu Lys Trp Tyr Lys Asp Ala 
                405                 410                 415     


His Val Ala Lys Gly Lys Ser Val Phe Leu Glu Gln Met Lys Lys Phe 
            420                 425                 430         


Val Glu Trp Leu Lys Asn Ala Glu Glu Glu Ser Glu Ser Glu Ala Glu 
        435                 440                 445             


Glu Gly Asp 
    450     


<210> 8078
<211> 315
<212> PRT
<213> Homo sapiens

<400> 8078
Met Ala Gly Gly Ala Arg Glu Val Leu Thr Leu Gln Leu Gly His Phe 
1               5                   10                  15      


Ala Gly Phe Val Gly Ala His Trp Trp Asn Gln Gln Asp Ala Ala Leu 
            20                  25                  30          


Gly Arg Ala Thr Asp Ser Lys Glu Pro Pro Gly Glu Leu Cys Pro Asp 
        35                  40                  45              


Val Leu Tyr Arg Thr Gly Arg Thr Leu His Gly Gln Glu Thr Tyr Thr 
    50                  55                  60                  


Pro Arg Leu Ile Leu Met Asp Leu Lys Gly Ser Leu Ser Ser Leu Lys 
65                  70                  75                  80  


Glu Glu Gly Gly Leu Tyr Arg Asp Lys Gln Leu Asp Ala Ala Ile Ala 
                85                  90                  95      


Trp Gln Gly Lys Leu Thr Thr His Lys Glu Glu Leu Tyr Pro Lys Asn 
            100                 105                 110         


Pro Tyr Leu Gln Asp Phe Leu Ser Ala Glu Gly Val Leu Ser Ser Asp 
        115                 120                 125             


Gly Val Trp Arg Val Lys Ser Ile Pro Asn Gly Lys Gly Ser Ser Pro 
    130                 135                 140                 


Leu Pro Thr Ala Thr Thr Pro Lys Pro Leu Ile Pro Thr Glu Ala Ser 
145                 150                 155                 160 


Ile Arg Val Trp Ser Asp Phe Leu Arg Val His Leu His Pro Arg Ser 
                165                 170                 175     


Ile Cys Met Ile Gln Lys Tyr Asn His Asp Gly Glu Ala Gly Arg Leu 
            180                 185                 190         


Glu Ala Phe Gly Gln Gly Glu Ser Val Leu Lys Glu Pro Lys Tyr Gln 
        195                 200                 205             


Glu Glu Leu Glu Asp Arg Leu His Phe Tyr Val Glu Glu Cys Asp Tyr 
    210                 215                 220                 


Leu Gln Val Val Ala Trp Gln Cys Ala Leu Gln Gly Gly Ser Ser Ser 
225                 230                 235                 240 


His Pro Ala Asn Tyr Leu Ser Ser Leu Thr Pro Ala Gln Gly Phe Gln 
                245                 250                 255     


Ile Leu Cys Asp Leu His Asp Gly Phe Ser Gly Val Gly Ala Lys Ala 
            260                 265                 270         


Ala Glu Leu Leu Gln Asp Glu Tyr Ser Gly Arg Gly Ile Ile Thr Trp 
        275                 280                 285             


Gly Leu Leu Pro Gly Pro Tyr His Arg Gly Val Ser Gly Thr Trp Arg 
    290                 295                 300                 


Ser Lys His Ser Asn Pro Ile Gly Arg Val Ala 
305                 310                 315 


<210> 8079
<211> 94
<212> PRT
<213> Homo sapiens

<400> 8079
Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys Gln Gln Ser Ser Cys Gln 
1               5                   10                  15      


Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro 
            20                  25                  30          


Val Cys Cys Lys Thr Val Cys Cys Lys Pro Ser Ser Cys Gln Pro Ala 
        35                  40                  45              


Cys Cys Ile Ser Ser Pro Cys Gln Gln Ser Cys Cys Val Pro Val Cys 
    50                  55                  60                  


Cys Lys Pro Ile Cys Cys Val Pro Pro Ala Cys Cys Thr Thr Ser Cys 
65                  70                  75                  80  


Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Val 
                85                  90                  


<210> 8080
<211> 406
<212> PRT
<213> Homo sapiens

<400> 8080
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Gly Ala His Val Thr Ile Asn Ala Arg Ala Glu Glu 
                85                  90                  95      


Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala Ser Gly 
            100                 105                 110         


Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp Val Gly 
        115                 120                 125             


Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Thr Asn Ala Val Ser 
    130                 135                 140                 


Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala Glu Lys 
145                 150                 155                 160 


Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu Glu Ala 
                165                 170                 175     


Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg Glu Ala 
            180                 185                 190         


Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala Ser Pro 
        195                 200                 205             


Gln Ser Arg Thr Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn Arg 
    210                 215                 220                 


Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln Lys 
225                 230                 235                 240 


Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly Lys 
                245                 250                 255     


Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr His 
            260                 265                 270         


Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp Leu 
        275                 280                 285             


Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln Ala 
    290                 295                 300                 


Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe Tyr 
305                 310                 315                 320 


Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His Ile 
                325                 330                 335     


Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys Ala 
            340                 345                 350         


Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser Phe 
        355                 360                 365             


Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly Trp 
    370                 375                 380                 


Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala Asn 
385                 390                 395                 400 


Tyr Val Glu Leu Ile Glu 
                405     


<210> 8081
<211> 326
<212> PRT
<213> Homo sapiens

<400> 8081
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 
                245                 250                 255     


Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 
            260                 265                 270         


Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 
        275                 280                 285             


Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 
    290                 295                 300                 


Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 
305                 310                 315                 320 


Ala Phe Pro Val Asp Gly 
                325     


<210> 8082
<211> 227
<212> PRT
<213> Homo sapiens

<400> 8082
Met Leu Cys Trp Gly Tyr Trp Ser Leu Gly Gln Pro Gly Ile Ser Thr 
1               5                   10                  15      


Asn Leu Gln Gly Ile Val Ala Glu Pro Gln Val Cys Gly Phe Ile Ser 
            20                  25                  30          


Asp Arg Ser Val Lys Glu Val Ala Cys Gly Gly Asn His Ser Val Phe 
        35                  40                  45              


Leu Leu Glu Asp Gly Glu Val Tyr Thr Cys Gly Leu Asn Thr Lys Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Arg Glu Gly Asn Lys Pro Glu Gln Ile Gly Ala 
65                  70                  75                  80  


Leu Ala Asp Gln His Ile Ile His Val Ala Cys Gly Glu Ser His Ser 
                85                  90                  95      


Leu Ala Leu Ser Asp Arg Gly Gln Leu Phe Ser Trp Gly Ala Gly Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Met Thr Thr Glu Asp Ser Val Ala Val Pro 
        115                 120                 125             


Arg Leu Ile Gln Lys Leu Asn Gln Gln Thr Ile Leu Gln Val Ser Cys 
    130                 135                 140                 


Gly Asn Trp His Cys Leu Ala Leu Ala Ala Asp Gly Gln Phe Phe Thr 
145                 150                 155                 160 


Trp Gly Lys Asn Ser His Gly Gln Leu Gly Leu Gly Lys Glu Phe Pro 
                165                 170                 175     


Ser Gln Ala Ser Pro Gln Arg Val Arg Ser Leu Glu Gly Ile Pro Leu 
            180                 185                 190         


Ala Gln Val Ala Ala Gly Gly Ala His Ser Phe Ala Leu Ser Leu Ser 
        195                 200                 205             


Gly Ala Val Phe Gly Trp Gly Met Asn Asn Ala Gly Gln Leu Gly Leu 
    210                 215                 220                 


Ser Asp Glu 
225         


<210> 8083
<211> 207
<212> PRT
<213> Homo sapiens

<400> 8083
Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro 
145                 150                 155                 160 


Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu 
                165                 170                 175     


Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala 
            180                 185                 190         


Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn 
        195                 200                 205         


<210> 8084
<211> 238
<212> PRT
<213> Homo sapiens

<400> 8084
Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala 
        35                  40                  45              


Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala 
    50                  55                  60                  


Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro 
                85                  90                  95      


Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys 
            100                 105                 110         


Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr 
        115                 120                 125             


Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro 
    130                 135                 140                 


Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr 
                165                 170                 175     


Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser 
            180                 185                 190         


Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu 
        195                 200                 205             


Val Phe Val Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met 
    210                 215                 220                 


Ala Leu Asn Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn 
225                 230                 235             


<210> 8085
<211> 122
<212> PRT
<213> Homo sapiens

<400> 8085
Val Arg Glu Leu Glu Ala Glu Leu Asp Ala Glu Gln Lys Lys His Ala 
1               5                   10                  15      


Glu Ala Leu Lys Gly Val Arg Lys His Glu Arg Arg Val Lys Glu Leu 
            20                  25                  30          


Ala Tyr Gln Ala Glu Glu Asp Arg Lys Asn Leu Ala Arg Met Gln Asp 
        35                  40                  45              


Leu Val Asp Lys Leu Gln Ser Lys Val Lys Ser Tyr Lys Arg Gln Phe 
    50                  55                  60                  


Glu Glu Ala Glu Gln Gln Ala Asn Thr Asn Leu Ala Lys Tyr Arg Lys 
65                  70                  75                  80  


Ala Gln His Glu Leu Asp Asp Ala Glu Glu Arg Ala Asp Met Ala Glu 
                85                  90                  95      


Thr Gln Ala Asn Lys Leu Arg Ala Arg Thr Arg Asp Ala Leu Gly Pro 
            100                 105                 110         


Lys Leu Ser Leu Ser Pro Gln His Lys Glu 
        115                 120         


<210> 8086
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8086
Xaa Glu Ser Leu Val Gly Leu Gln Glu Gly Lys Ser Thr Glu Gln Gly 
1               5                   10                  15      


Asn His Asp Gln Leu Lys Glu Leu Tyr Ser Ala Gly Asn Leu Thr Val 
            20                  25                  30          


Leu Ala Thr Asp Pro Leu Leu His Gln Asp Pro Val Gln Leu Asp Phe 
        35                  40                  45              


His Phe Arg Leu Thr Ser Gln Thr Ser Ala His Trp His Gly Leu Leu 
    50                  55                  60                  


Cys Asp Arg Arg Leu Phe Leu Asp Ile Pro Tyr Gln Ala Leu Asp Gln 
65                  70                  75                  80  


Gly Asn Arg Glu Ser Leu Thr Ala Thr Leu Glu Tyr Val Glu Glu Lys 
                85                  90                  95      


Thr Asn Val Asp Ser Val Phe Val Asn Phe Gln Asn Asp Arg Asn Asp 
            100                 105                 110         


Arg Gly Ala Leu Leu Arg Ala Phe Ser Tyr Met Gly Phe Glu Val Val 
        115                 120                 125             


Arg Pro Asp His Pro Ala Leu Pro Pro Leu Asp Asn Val Ile Phe Met 
    130                 135                 140                 


Val Tyr Pro Leu Glu Arg Asp Val Gly His Leu Pro Ser Glu Pro Pro 
145                 150                 155                 160 


<210> 8087
<211> 33
<212> PRT
<213> Homo sapiens

<400> 8087
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp 
    


<210> 8088
<211> 133
<212> PRT
<213> Homo sapiens

<400> 8088
Met Trp Ser Leu Thr Ala Ser Glu Gly Glu Ser Thr Thr Ala His Phe 
1               5                   10                  15      


Phe Leu Gly Ala Gly Asp Glu Gly Leu Gly Thr Arg Gly Ile Gly Met 
            20                  25                  30          


Arg Pro Glu Glu Ser Asp Ser Glu Leu Leu Glu Asp Glu Glu Asp Glu 
        35                  40                  45              


Val Pro Pro Glu Pro Gln Ile Ile Val Gly Ile Cys Ala Met Thr Lys 
    50                  55                  60                  


Lys Ser Lys Ser Lys Pro Met Thr Gln Ile Leu Glu Arg Leu Cys Arg 
65                  70                  75                  80  


Phe Asp Tyr Leu Thr Val Val Ile Leu Gly Glu Asp Val Ile Leu Asn 
                85                  90                  95      


Glu Pro Val Glu Asn Trp Pro Ser Cys His Cys Leu Ile Ser Phe His 
            100                 105                 110         


Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ser Lys Leu Arg 
        115                 120                 125             


Asn Pro Phe Leu Ile 
    130             


<210> 8089
<211> 312
<212> PRT
<213> Homo sapiens

<400> 8089
Met Ala Gln Pro Tyr Pro Pro Ala Gln Tyr Pro Pro Pro Pro Gln Asn 
1               5                   10                  15      


Gly Ile Pro Ala Glu Tyr Ala Pro Pro Pro Pro His Pro Thr Gln Asp 
            20                  25                  30          


Tyr Ser Gly Gln Thr Pro Val Pro Thr Glu His Gly Met Thr Leu Tyr 
        35                  40                  45              


Thr Pro Ala Gln Thr His Pro Glu Gln Pro Gly Ser Glu Ala Ser Thr 
    50                  55                  60                  


Gln Pro Ile Ala Gly Thr Gln Thr Val Pro Gln Thr Asp Glu Ala Ala 
65                  70                  75                  80  


Gln Thr Asp Ser Gln Pro Leu His Pro Ser Asp Pro Thr Glu Lys Gln 
                85                  90                  95      


Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp 
            100                 105                 110         


Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val 
        115                 120                 125             


Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr 
    130                 135                 140                 


Phe Glu Thr Ser Ser Asp Ala Asp Arg Ala Arg Glu Lys Leu Asn Gly 
145                 150                 155                 160 


Thr Ile Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg 
                165                 170                 175     


Val Met Thr Asn Lys Lys Thr Gly Asn Pro Tyr Thr Asn Gly Trp Lys 
            180                 185                 190         


Leu Asn Pro Val Val Gly Ala Val Tyr Gly Pro Glu Phe Tyr Ala Val 
        195                 200                 205             


Thr Gly Phe Pro Tyr Pro Thr Thr Gly Thr Ala Val Ala Tyr Arg Gly 
    210                 215                 220                 


Ala His Leu Arg Gly Arg Gly Arg Ala Val Tyr Asn Thr Phe Arg Ala 
225                 230                 235                 240 


Ala Pro Pro Pro Pro Pro Ile Pro Thr Tyr Gly Ala Val Val Tyr Gln 
                245                 250                 255     


Asp Gly Phe Tyr Gly Ala Glu Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg 
            260                 265                 270         


Tyr Ala Gln Pro Ala Ala Ala Ala Ala Ala Tyr Ser Asp Ser Tyr Gly 
        275                 280                 285             


Arg Val Tyr Ala Ala Ala Asp Pro Tyr His His Thr Ile Gly Pro Ala 
    290                 295                 300                 


Ala Thr Tyr Ser Ile Gly Thr Met 
305                 310         


<210> 8090
<211> 435
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8090
Xaa Ser Ile Leu Asn Ser Asn Glu His Leu Leu Lys Glu Lys Glu Leu 
1               5                   10                  15      


Leu Ile Asp Lys Gln Arg Lys His Ile Ser Gln Leu Glu Gln Lys Val 
            20                  25                  30          


Arg Glu Ser Glu Leu Gln Val His Ser Ala Leu Leu Gly Arg Pro Ala 
        35                  40                  45              


Pro Phe Gly Asp Val Cys Leu Leu Arg Leu Gln Glu Leu Gln Arg Glu 
    50                  55                  60                  


Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln Lys Thr Glu Ala Leu Ser 
65                  70                  75                  80  


Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu Ser Ala Ser Glu Val Glu 
                85                  90                  95      


Val Gln Leu Ile Arg Glu Ser Leu Lys Val Ala Leu Gln Lys His Ser 
            100                 105                 110         


Glu Glu Val Lys Lys Gln Glu Glu Arg Val Lys Gly Arg Asp Lys His 
        115                 120                 125             


Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys Glu Ser Glu Gln Asn Arg 
    130                 135                 140                 


Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu Arg Tyr Leu Ala Asp Leu 
145                 150                 155                 160 


Pro Thr Leu Glu Asp His Gln Lys Gln Ser Gln Gln Leu Lys Asp Ser 
                165                 170                 175     


Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys Val Thr Glu Leu Glu Ser 
            180                 185                 190         


Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg Glu Lys Glu Ile Gln Leu 
        195                 200                 205             


Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe Ser Ser Ala Gly His Ser 
    210                 215                 220                 


Leu Gln Asp Lys Gln Ser Val Glu Glu Thr Ser Gly Glu Gly Pro Glu 
225                 230                 235                 240 


Val Glu Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser Leu Gln Lys Ile 
                245                 250                 255     


Val Glu Lys Gln Gln Gln Lys Met Asp Gln Leu Arg Ser Gln Val Gln 
            260                 265                 270         


Ser Leu Glu Gln Glu Val Ala Gln Glu Glu Gly Thr Ser Gln Ala Leu 
        275                 280                 285             


Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala Leu Gln Gln Leu Arg Thr 
    290                 295                 300                 


Ala Val Lys Glu Leu Ser Val Gln Asn Gln Asp Leu Ile Glu Lys Asn 
305                 310                 315                 320 


Leu Thr Leu Gln Glu His Leu Arg Gln Ala Gln Pro Gly Ser Pro Pro 
                325                 330                 335     


Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu Leu His Gln Glu Leu Ala 
            340                 345                 350         


Ser Cys Leu Gln Asp Leu Gln Ala Val Cys Ser Ile Val Thr Gln Arg 
        355                 360                 365             


Ala Gln Gly His Asp Pro Asn Leu Ser Leu Leu Leu Gly Ile His Ser 
    370                 375                 380                 


Gln His Pro Glu Thr Gln Leu Asp Leu Gln Lys Pro Asp Val Ile Lys 
385                 390                 395                 400 


Arg Lys Leu Glu Glu Val Gln Gln Leu Arg Arg Asp Ile Glu Asp Leu 
                405                 410                 415     


Arg Thr Thr Met Ser Asp Arg Tyr Ala Gln Asp Met Gly Glu Asn Cys 
            420                 425                 430         


Val Thr Gln 
        435 


<210> 8091
<211> 157
<212> PRT
<213> Homo sapiens

<400> 8091
Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser 
1               5                   10                  15      


Gly Asn Leu Ala His Val Glu Lys Val Glu Ser Leu Ser Ser Asp Gly 
            20                  25                  30          


Glu Gly Val Gly Gly Gly Ala Ser Ala Leu Thr Ser Gly Ile Ala Ser 
        35                  40                  45              


Ser Pro Asp Tyr Glu Phe Asn Val Trp Thr Arg Pro Asp Cys Ala Glu 
    50                  55                  60                  


Thr Glu Phe Glu Asn Gly Asn Arg Ser Trp Phe Tyr Phe Ser Val Arg 
65                  70                  75                  80  


Gly Gly Met Pro Gly Lys Leu Ile Lys Ile Asn Ile Met Asn Met Asn 
                85                  90                  95      


Lys Gln Ser Lys Leu Tyr Ser Gln Gly Met Ala Pro Phe Val Arg Thr 
            100                 105                 110         


Leu Pro Thr Arg Pro Arg Trp Glu Arg Ile Arg Asp Arg Pro Thr Phe 
        115                 120                 125             


Glu Met Thr Glu Thr Gln Phe Val Leu Ser Phe Val His Arg Phe Val 
    130                 135                 140                 


Glu Gly Arg Gly Ala Thr Thr Phe Phe Ala Phe Cys Tyr 
145                 150                 155         


<210> 8092
<211> 539
<212> PRT
<213> Homo sapiens

<400> 8092
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 8093
<211> 2046
<212> PRT
<213> Homo sapiens

<400> 8093
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu 
            100                 105                 110         


Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser 
    130                 135                 140                 


Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln 
145                 150                 155                 160 


Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser 
                165                 170                 175     


Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu 
            180                 185                 190         


Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val 
        195                 200                 205             


Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu 
    210                 215                 220                 


Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu 
225                 230                 235                 240 


Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser 
                245                 250                 255     


Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser 
            260                 265                 270         


Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser 
        275                 280                 285             


Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His 
    290                 295                 300                 


Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu 
305                 310                 315                 320 


Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn 
                325                 330                 335     


Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val 
            340                 345                 350         


Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu 
        355                 360                 365             


Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu 
    370                 375                 380                 


Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met 
385                 390                 395                 400 


Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu 
                405                 410                 415     


Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala 
            420                 425                 430         


Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala 
        435                 440                 445             


Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr 
    450                 455                 460                 


Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn 
465                 470                 475                 480 


Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Lys Leu Ala Glu 
                485                 490                 495     


Tyr Glu Asn Leu Thr Asn Lys Leu Gln Arg Asn Leu Glu Asn Val Leu 
            500                 505                 510         


Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu 
        515                 520                 525             


Gln Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys 
    530                 535                 540                 


Arg Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu 
545                 550                 555                 560 


Tyr Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro 
                565                 570                 575     


Ser Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly 
            580                 585                 590         


Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu 
        595                 600                 605             


Leu Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys 
    610                 615                 620                 


Leu Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu 
625                 630                 635                 640 


Asp Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln 
                645                 650                 655     


Arg His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu 
            660                 665                 670         


Lys Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu 
        675                 680                 685             


Ala His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu 
    690                 695                 700                 


Gln Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg 
705                 710                 715                 720 


Leu Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala 
                725                 730                 735     


Ser Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu 
            740                 745                 750         


Glu Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu 
        755                 760                 765             


Gln Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu 
    770                 775                 780                 


Arg Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg 
785                 790                 795                 800 


Glu Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala 
                805                 810                 815     


Gln Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala 
            820                 825                 830         


Leu Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln 
        835                 840                 845             


Glu Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu 
    850                 855                 860                 


Leu Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu 
865                 870                 875                 880 


Lys Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met 
                885                 890                 895     


Leu Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg 
            900                 905                 910         


Gln Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr 
        915                 920                 925             


Gln Gln Ser Leu Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His 
    930                 935                 940                 


Lys Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala 
945                 950                 955                 960 


Ser Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His 
                965                 970                 975     


Asp Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn 
            980                 985                 990         


Ile His Lys Ala Thr Cys Glu Thr  Ala Asp Arg Glu Arg  Ala Glu Met 
        995                 1000                 1005             


Ser Thr  Glu Ile Ser Arg Leu  Gln Ser Lys Ile Lys  Glu Met Gln 
    1010                 1015                 1020             


Gln Ala  Thr Ser Pro Leu Ser  Met Leu Gln Ser Gly  Cys Gln Val 
    1025                 1030                 1035             


Ile Gly  Glu Glu Glu Val Glu  Gly Asp Gly Ala Leu  Ser Leu Leu 
    1040                 1045                 1050             


Gln Gln  Gly Glu Gln Leu Leu  Glu Glu Asn Gly Asp  Val Leu Leu 
    1055                 1060                 1065             


Ser Leu  Gln Arg Ala His Glu  Gln Ala Val Lys Glu  Asn Val Lys 
    1070                 1075                 1080             


Met Ala  Thr Glu Ile Ser Arg  Leu Gln Gln Arg Leu  Gln Lys Leu 
    1085                 1090                 1095             


Glu Pro  Gly Leu Val Met Ser  Ser Cys Leu Asp Glu  Pro Ala Thr 
    1100                 1105                 1110             


Glu Phe  Phe Gly Asn Thr Ala  Glu Gln Thr Glu Gln  Phe Leu Gln 
    1115                 1120                 1125             


Gln Asn  Arg Thr Lys Gln Val  Glu Gly Val Thr Arg  Arg His Val 
    1130                 1135                 1140             


Leu Ser  Asp Leu Glu Asp Asp  Glu Val Arg Asp Leu  Gly Ser Thr 
    1145                 1150                 1155             


Gly Thr  Ser Ser Val Gln Arg  Gln Glu Val Lys Ile  Glu Glu Ser 
    1160                 1165                 1170             


Glu Ala  Ser Val Glu Gly Phe  Ser Glu Leu Glu Asn  Ser Glu Glu 
    1175                 1180                 1185             


Thr Arg  Thr Glu Ser Trp Glu  Leu Lys Asn Gln Ile  Ser Gln Leu 
    1190                 1195                 1200             


Gln Glu  Gln Leu Met Met Leu  Cys Ala Asp Cys Asp  Arg Ala Ser 
    1205                 1210                 1215             


Glu Lys  Lys Gln Asp Leu Leu  Phe Asp Val Ser Val  Leu Lys Lys 
    1220                 1225                 1230             


Lys Leu  Lys Met Leu Glu Arg  Ile Pro Glu Ala Ser  Pro Lys Tyr 
    1235                 1240                 1245             


Lys Leu  Leu Tyr Glu Asp Val  Ser Arg Glu Asn Asp  Cys Leu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Arg Met Met Glu  Thr Arg Tyr Asp Glu  Ala Leu Glu 
    1265                 1270                 1275             


Asn Asn  Lys Glu Leu Thr Ala  Glu Val Phe Arg Leu  Gln Asp Glu 
    1280                 1285                 1290             


Leu Lys  Lys Met Glu Glu Val  Thr Glu Thr Phe Leu  Ser Leu Glu 
    1295                 1300                 1305             


Lys Ser  Tyr Asp Glu Val Lys  Ile Glu Asn Glu Gly  Leu Asn Val 
    1310                 1315                 1320             


Leu Val  Leu Arg Leu Gln Gly  Lys Ile Glu Lys Leu  Gln Glu Ser 
    1325                 1330                 1335             


Val Val  Gln Arg Cys Asp Cys  Cys Leu Trp Glu Ala  Ser Leu Glu 
    1340                 1345                 1350             


Asn Leu  Glu Ile Glu Pro Asp  Gly Asn Ile Leu Gln  Leu Asn Gln 
    1355                 1360                 1365             


Thr Leu  Glu Glu Cys Val Pro  Arg Val Arg Ser Val  His His Val 
    1370                 1375                 1380             


Ile Glu  Glu Cys Lys Gln Glu  Asn Gln Tyr Leu Glu  Gly Asn Thr 
    1385                 1390                 1395             


Gln Leu  Leu Glu Lys Val Lys  Ala His Glu Ile Ala  Trp Leu His 
    1400                 1405                 1410             


Gly Thr  Ile Gln Thr His Gln  Glu Arg Pro Arg Val  Gln Asn Gln 
    1415                 1420                 1425             


Val Ile  Leu Glu Glu Asn Thr  Thr Leu Leu Gly Phe  Gln Asp Lys 
    1430                 1435                 1440             


His Phe  Gln His Gln Ala Thr  Ile Ala Glu Leu Glu  Leu Glu Lys 
    1445                 1450                 1455             


Thr Lys  Leu Gln Glu Leu Thr  Arg Lys Leu Lys Glu  Arg Val Thr 
    1460                 1465                 1470             


Ile Leu  Val Lys Gln Lys Asp  Val Leu Ser His Gly  Glu Lys Glu 
    1475                 1480                 1485             


Glu Glu  Leu Lys Ala Met Met  His Asp Leu Gln Ile  Thr Cys Ser 
    1490                 1495                 1500             


Glu Met  Gln Gln Lys Val Glu  Leu Leu Arg Tyr Glu  Ser Glu Lys 
    1505                 1510                 1515             


Leu Gln  Gln Glu Asn Ser Ile  Leu Arg Asn Glu Ile  Thr Thr Leu 
    1520                 1525                 1530             


Asn Glu  Glu Asp Ser Ile Ser  Asn Leu Lys Leu Gly  Thr Leu Asn 
    1535                 1540                 1545             


Gly Ser  Gln Glu Glu Met Trp  Gln Lys Thr Glu Thr  Val Lys Gln 
    1550                 1555                 1560             


Glu Asn  Ala Ala Val Gln Lys  Met Val Glu Asn Leu  Lys Lys Gln 
    1565                 1570                 1575             


Ile Ser  Glu Leu Lys Ile Lys  Asn Gln Gln Leu Asp  Leu Glu Asn 
    1580                 1585                 1590             


Thr Glu  Leu Ser Gln Lys Asn  Ser Gln Asn Gln Glu  Lys Leu Gln 
    1595                 1600                 1605             


Glu Leu  Asn Gln Arg Leu Thr  Glu Met Leu Cys Gln  Lys Glu Lys 
    1610                 1615                 1620             


Glu Pro  Gly Asn Ser Ala Leu  Glu Glu Arg Glu Gln  Glu Lys Phe 
    1625                 1630                 1635             


Asn Leu  Lys Glu Glu Leu Glu  Arg Cys Lys Val Gln  Ser Ser Thr 
    1640                 1645                 1650             


Leu Val  Ser Ser Leu Glu Ala  Glu Leu Ser Glu Val  Lys Ile Gln 
    1655                 1660                 1665             


Thr His  Ile Val Gln Gln Glu  Asn His Leu Leu Lys  Asp Glu Leu 
    1670                 1675                 1680             


Glu Lys  Met Lys Gln Leu His  Arg Cys Pro Asp Leu  Ser Asp Phe 
    1685                 1690                 1695             


Gln Gln  Lys Ile Ser Ser Val  Leu Ser Tyr Asn Glu  Lys Leu Leu 
    1700                 1705                 1710             


Lys Glu  Lys Glu Ala Leu Ser  Glu Glu Leu Asn Ser  Cys Val Asp 
    1715                 1720                 1725             


Lys Leu  Ala Lys Ser Ser Leu  Leu Glu His Arg Ile  Ala Thr Met 
    1730                 1735                 1740             


Lys Gln  Glu Gln Lys Ser Trp  Glu His Gln Ser Ala  Ser Leu Lys 
    1745                 1750                 1755             


Ser Gln  Leu Val Ala Ser Gln  Glu Lys Val Gln Asn  Leu Glu Asp 
    1760                 1765                 1770             


Thr Val  Gln Asn Val Asn Leu  Gln Met Ser Arg Met  Lys Ser Asp 
    1775                 1780                 1785             


Leu Arg  Val Thr Gln Gln Glu  Lys Glu Ala Leu Lys  Gln Glu Val 
    1790                 1795                 1800             


Met Ser  Leu His Lys Gln Leu  Gln Asn Ala Gly Gly  Lys Ser Trp 
    1805                 1810                 1815             


Ala Pro  Glu Ile Ala Thr His  Pro Ser Gly Leu His  Asn Gln Gln 
    1820                 1825                 1830             


Lys Arg  Leu Ser Trp Asp Lys  Leu Asp His Leu Met  Asn Glu Glu 
    1835                 1840                 1845             


Gln Gln  Leu Leu Trp Gln Glu  Asn Glu Arg Leu Gln  Thr Met Val 
    1850                 1855                 1860             


Gln Asn  Thr Lys Ala Glu Leu  Thr His Ser Arg Glu  Lys Val Arg 
    1865                 1870                 1875             


Gln Leu  Glu Ser Asn Leu Leu  Pro Lys His Gln Lys  His Leu Asn 
    1880                 1885                 1890             


Pro Ser  Gly Thr Met Asn Pro  Thr Glu Gln Glu Lys  Leu Ser Leu 
    1895                 1900                 1905             


Lys Arg  Glu Cys Asp Gln Phe  Gln Lys Glu Gln Ser  Pro Ala Asn 
    1910                 1915                 1920             


Arg Lys  Val Ser Gln Met Asn  Ser Leu Glu Gln Glu  Leu Glu Thr 
    1925                 1930                 1935             


Ile His  Leu Glu Asn Glu Gly  Leu Lys Lys Lys Gln  Val Lys Leu 
    1940                 1945                 1950             


Asp Glu  Gln Leu Met Glu Met  Gln His Leu Arg Ser  Thr Ala Thr 
    1955                 1960                 1965             


Pro Ser  Pro Ser Pro His Ala  Trp Asp Leu Gln Leu  Leu Gln Gln 
    1970                 1975                 1980             


Gln Ala  Cys Pro Met Val Pro  Arg Glu Gln Phe Leu  Gln Leu Gln 
    1985                 1990                 1995             


Arg Gln  Leu Leu Gln Ala Glu  Arg Ile Asn Gln His  Leu Gln Glu 
    2000                 2005                 2010             


Glu Leu  Glu Asn Arg Thr Ser  Glu Thr Asn Thr Pro  Gln Ala Leu 
    2015                 2020                 2025             


Leu Pro  Glu Gln Arg Ala Val  His Ala Asp Ser Tyr  Arg Arg Ile 
    2030                 2035                 2040             


Gly His  Leu 
    2045     


<210> 8094
<211> 400
<212> PRT
<213> Homo sapiens

<400> 8094
Met Ala Gly Glu Asn His Gln Trp Gln Gly Ser Ile Leu Tyr Asn Met 
1               5                   10                  15      


Leu Met Ser Ala Lys Gln Thr Arg Ala Ala Pro Glu Ala Pro Glu Thr 
            20                  25                  30          


Arg Leu Val Asp Gln Cys Trp Gly Cys Ser Cys Gly Asp Glu Pro Gly 
        35                  40                  45              


Val Gly Arg Glu Gly Leu Leu Gly Gly Arg Asn Val Ala Leu Leu Tyr 
    50                  55                  60                  


Arg Cys Cys Phe Cys Gly Lys Asp His Pro Arg Gln Gly Ser Ile Leu 
65                  70                  75                  80  


Tyr Ser Met Leu Thr Ser Ala Lys Gln Thr Tyr Ala Ala Pro Lys Ala 
                85                  90                  95      


Pro Glu Ala Thr Leu Gly Pro Cys Trp Gly Cys Ser Cys Gly Ser Asp 
            100                 105                 110         


Pro Gly Val Gly Arg Ala Gly Leu Pro Gly Gly Arg Pro Val Ala Leu 
        115                 120                 125             


Leu Tyr Arg Cys Cys Phe Cys Gly Glu Asp His Pro Arg Gln Gly Ser 
    130                 135                 140                 


Ile Leu Tyr Ser Leu Leu Thr Ser Ser Lys Gln Thr His Val Ala Pro 
145                 150                 155                 160 


Ala Ala Pro Glu Ala Arg Pro Gly Gly Ala Trp Trp Asp Arg Ser Tyr 
                165                 170                 175     


Phe Ala Gln Arg Pro Gly Gly Lys Glu Ala Leu Pro Gly Gly Arg Ala 
            180                 185                 190         


Thr Ala Leu Leu Tyr Arg Cys Cys Phe Cys Gly Glu Asp His Pro Gln 
        195                 200                 205             


Gln Gly Ser Thr Leu Tyr Cys Val Pro Thr Ser Thr Asn Gln Ala Gln 
    210                 215                 220                 


Ala Ala Pro Glu Glu Arg Pro Arg Ala Pro Trp Trp Asp Thr Ser Ser 
225                 230                 235                 240 


Gly Ala Leu Arg Pro Val Ala Leu Lys Ser Pro Gln Val Val Cys Glu 
                245                 250                 255     


Ala Ala Ser Ala Gly Leu Leu Lys Thr Leu Arg Phe Val Lys Tyr Leu 
            260                 265                 270         


Pro Cys Phe Gln Val Leu Pro Leu Asp Gln Gln Leu Val Leu Val Arg 
        275                 280                 285             


Asn Cys Trp Ala Ser Leu Leu Met Leu Glu Leu Ala Gln Asp Arg Leu 
    290                 295                 300                 


Gln Phe Glu Thr Val Glu Val Ser Glu Pro Ser Met Leu Gln Lys Ile 
305                 310                 315                 320 


Leu Thr Thr Arg Arg Arg Glu Thr Gly Gly Asn Glu Pro Leu Pro Val 
                325                 330                 335     


Pro Thr Leu Gln His His Leu Ala Pro Pro Ala Glu Ala Arg Lys Val 
            340                 345                 350         


Pro Ser Ala Ser Gln Val Gln Ala Ile Lys Cys Phe Leu Ser Lys Cys 
        355                 360                 365             


Trp Ser Leu Asn Ile Ser Thr Lys Glu Tyr Ala Tyr Leu Lys Gly Thr 
    370                 375                 380                 


Val Leu Phe Asn Pro Gly Lys Gly Lys Glu Asn Asp Cys Asn His His 
385                 390                 395                 400 


<210> 8095
<211> 208
<212> PRT
<213> Homo sapiens

<400> 8095
Met Lys Gln Leu Glu Asp His Glu Ala Phe Glu Thr Ser Ser Leu Ile 
1               5                   10                  15      


Gly His Ser Ala Arg Val Tyr Ala Leu Tyr Tyr Lys Asp Gly Leu Leu 
            20                  25                  30          


Cys Thr Gly Ser Asp Asp Leu Ser Ala Lys Leu Trp Asp Val Ser Thr 
        35                  40                  45              


Gly Gln Cys Val Tyr Gly Ile Gln Thr His Thr Cys Ala Ala Val Lys 
    50                  55                  60                  


Phe Asp Glu Gln Lys Leu Val Thr Gly Ser Phe Asp Asn Thr Val Ala 
65                  70                  75                  80  


Cys Trp Glu Trp Ser Ser Gly Ala Arg Thr Gln His Phe Arg Gly His 
                85                  90                  95      


Thr Gly Ala Val Phe Ser Val Asp Tyr Asn Asp Glu Leu Asp Ile Leu 
            100                 105                 110         


Val Ser Gly Ser Ala Asp Phe Thr Val Lys Val Trp Ala Leu Ser Ala 
        115                 120                 125             


Gly Thr Cys Leu Asn Thr Leu Thr Gly His Thr Glu Trp Val Thr Lys 
    130                 135                 140                 


Val Val Leu Gln Lys Cys Lys Val Lys Ser Leu Leu His Ser Pro Gly 
145                 150                 155                 160 


Asp Tyr Ile Leu Leu Ser Ala Asp Lys Tyr Glu Ile Lys Ile Trp Pro 
                165                 170                 175     


Ile Gly Arg Glu Ile Asn Cys Lys Cys Leu Lys Thr Leu Ser Val Ser 
            180                 185                 190         


Glu Asp Arg Ser Ile Cys Leu Gln Pro Arg Leu His Phe Asp Gly Lys 
        195                 200                 205             


<210> 8096
<211> 212
<212> PRT
<213> Homo sapiens

<400> 8096
Met Phe Gly Val Thr Lys Phe Gly Asp Asn Ile Glu Asp Glu Trp Phe 
1               5                   10                  15      


Ile Val Tyr Val Ile Lys Gln Ile Thr Lys Glu Phe Pro Glu Leu Val 
            20                  25                  30          


Ala Arg Ile Glu Asp Asn Asp Gly Glu Phe Leu Leu Ile Glu Ala Ala 
        35                  40                  45              


Asp Phe Leu Pro Lys Trp Leu Asp Pro Glu Asn Ser Thr Asn Arg Val 
    50                  55                  60                  


Phe Phe Cys His Gly Glu Leu Cys Ile Ile Pro Ala Pro Arg Lys Ser 
65                  70                  75                  80  


Gly Ala Glu Ser Trp Leu Pro Thr Thr Pro Pro Thr Ile Pro Gln Ala 
                85                  90                  95      


Leu Asn Ile Ile Thr Ala His Ser Glu Lys Ile Leu Ala Ser Glu Ser 
            100                 105                 110         


Ile Arg Ala Ala Val Asn Arg Arg Ile Arg Gly Tyr Pro Glu Lys Ile 
        115                 120                 125             


Gln Ala Ser Leu His Arg Ala His Cys Phe Leu Pro Ala Gly Ile Val 
    130                 135                 140                 


Ala Val Leu Lys Gln Arg Pro Arg Leu Val Ala Ala Ala Val Gln Ala 
145                 150                 155                 160 


Phe Tyr Leu Arg Asp Pro Ile Asp Leu Arg Ala Cys Arg Val Phe Lys 
                165                 170                 175     


Thr Phe Leu Pro Glu Thr Arg Ile Met Thr Ser Val Thr Phe Thr Lys 
            180                 185                 190         


Cys Leu Tyr Ala Gln Leu Val Gln Gln Arg Phe Val Pro Asp Arg Arg 
        195                 200                 205             


Ser Gly Tyr Arg 
    210         


<210> 8097
<211> 157
<212> PRT
<213> Homo sapiens

<400> 8097
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg 
145                 150                 155         


<210> 8098
<211> 1590
<212> PRT
<213> Homo sapiens

<400> 8098
Met Ser Ala Thr Ser Trp Phe Leu Val Ser Ser Ser Gly Ala Arg His 
1               5                   10                  15      


Arg Leu Pro Arg Glu Leu Ile Phe Val Gly Arg Glu Glu Cys Glu Leu 
            20                  25                  30          


Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr 
        35                  40                  45              


Asp Gln Asp Arg Asp Glu His Trp Val Lys Asp Leu Gly Ser Leu Asn 
    50                  55                  60                  


Gly Thr Phe Val Asn Asp Met Arg Ile Pro Asp Gln Lys Tyr Val Thr 
65                  70                  75                  80  


Leu Lys Leu Asn Asp Val Ile Arg Phe Gly Tyr Asp Ser Asn Met Tyr 
                85                  90                  95      


Val Leu Glu Arg Val Gln His Arg Val Pro Glu Glu Ala Leu Lys His 
            100                 105                 110         


Glu Lys Tyr Thr Ser Gln Leu Gln Val Ser Val Lys Gly Leu Ala Pro 
        115                 120                 125             


Lys Arg Ser Glu Ala Leu Pro Glu His Thr Pro Tyr Cys Glu Ala Ser 
    130                 135                 140                 


Asn Pro Arg Pro Glu Lys Gly Asp Arg Arg Pro Gly Thr Glu Ala Ala 
145                 150                 155                 160 


Ser Tyr Arg Thr Pro Leu Tyr Gly Gln Pro Ser Trp Trp Gly Glu Asp 
                165                 170                 175     


Asp Gly Ser Thr Leu Pro Asp Ala Gln Arg Gln Gly Glu Pro Tyr Pro 
            180                 185                 190         


Ala Glu Arg Pro Lys Gly Pro Val Gln Gln Asp Gly Glu Leu His Gly 
        195                 200                 205             


Phe Arg Ala Pro Ala Glu Pro Gln Gly Cys Ser Phe Arg Arg Glu Pro 
    210                 215                 220                 


Ser Tyr Phe Glu Ile Pro Thr Lys Glu Thr Pro Gln Pro Ser Gln Pro 
225                 230                 235                 240 


Pro Glu Val Pro Ala His Glu Met Pro Thr Lys Asp Ala Glu Ala Gly 
                245                 250                 255     


Gly Gly Gly Ala Ala Pro Val Val Gln Ser His Ala Ser Phe Thr Ile 
            260                 265                 270         


Glu Phe Asp Asp Cys Ser Pro Gly Lys Met Lys Ile Lys Asp His Ile 
        275                 280                 285             


Thr Lys Phe Ser Leu Arg Gln Arg Arg Pro Pro Gly Lys Glu Ala Thr 
    290                 295                 300                 


Pro Gly Glu Met Val Ser Ala Glu Thr Lys Val Ala Asp Trp Leu Val 
305                 310                 315                 320 


Gln Asn Asp Pro Ser Leu Leu His Arg Val Gly Pro Gly Asp Asp Arg 
                325                 330                 335     


His Ser Thr Lys Ser Asp Leu Pro Val His Thr Arg Thr Leu Lys Gly 
            340                 345                 350         


His Lys His Glu Asp Gly Thr Gln Ser Asp Ser Glu Asp Pro Leu Ala 
        355                 360                 365             


Lys Ala Ala Ser Ala Ala Gly Val Pro Leu Glu Ala Ser Gly Glu Gln 
    370                 375                 380                 


Val Arg Leu Gln Arg Gln Ile Lys Arg Asp Pro Gln Glu Leu Leu His 
385                 390                 395                 400 


Asn Gln Gln Ala Phe Val Ile Glu Phe Phe Asp Glu Asp Thr Pro Arg 
                405                 410                 415     


Lys Lys Arg Ser Gln Ser Phe Thr His Ser Pro Ser Gly Asp Pro Lys 
            420                 425                 430         


Ala Asp Lys Arg Arg Gly Pro Thr Pro Ala Asp Arg Asp Arg Pro Ser 
        435                 440                 445             


Val Pro Ala Pro Val Gln Ala Gly Gly Arg Ser Ser Gly Pro Gln Arg 
    450                 455                 460                 


Ala Gly Ser Leu Lys Arg Glu Lys Thr Glu Glu Arg Leu Gly Ser Pro 
465                 470                 475                 480 


Ser Pro Ala Ser Arg Thr Pro Ala Arg Pro Phe Gly Ser Val Gly Arg 
                485                 490                 495     


Arg Ser Arg Leu Ala Gln Asp Phe Met Ala Gln Cys Leu Arg Glu Ser 
            500                 505                 510         


Ser Pro Ala Ala Arg Pro Ser Pro Glu Lys Val Pro Pro Val Leu Pro 
        515                 520                 525             


Ala Pro Leu Thr Pro His Gly Thr Ser Pro Val Gly Pro Pro Thr Pro 
    530                 535                 540                 


Pro Pro Ala Pro Thr Asp Pro Gln Leu Thr Lys Ala Arg Lys Gln Glu 
545                 550                 555                 560 


Glu Asp Asp Ser Leu Ser Asp Ala Gly Thr Tyr Thr Ile Glu Thr Glu 
                565                 570                 575     


Ala Gln Asp Thr Glu Val Glu Glu Ala Arg Lys Met Ile Asp Gln Val 
            580                 585                 590         


Phe Gly Val Leu Glu Ser Pro Glu Leu Ser Arg Ala Ser Ser Ala Thr 
        595                 600                 605             


Phe Arg Pro Val Ile Arg Gly Asp Arg Asp Glu Ser Asp Asp Gly Gly 
    610                 615                 620                 


Val Ala Gln Arg Met Ala Leu Leu Gln Glu Phe Ala Ser Arg Pro Leu 
625                 630                 635                 640 


Gly Ala Ala Pro Gln Ala Glu His Gln Gly Leu Pro Val Pro Gly Ser 
                645                 650                 655     


Pro Gly Gly Gln Lys Trp Val Ser Arg Trp Ala Ser Leu Ala Asp Ser 
            660                 665                 670         


Tyr Ser Asp Pro Gly Leu Thr Glu Asp Gly Leu Gly Arg Arg Gly Gly 
        675                 680                 685             


Glu Pro Glu Gly Ser Leu Pro Val Arg Met Arg Arg Arg Leu Pro Gln 
    690                 695                 700                 


Leu Pro Ser Glu Arg Ala Asp Ser Pro Ala Gly Pro Glu Ser Ser Arg 
705                 710                 715                 720 


Arg Ser Gly Pro Gly Pro Pro Glu Leu Asp Ser Glu Gln Pro Ser Arg 
                725                 730                 735     


Leu Phe Gly Gln Glu Glu Leu Asp Pro Asp Ser Leu Ser Asp Ala Ser 
            740                 745                 750         


Gly Ser Asp Gly Gly Arg Gly Pro Glu Pro Gly Val Glu Pro Gln Asp 
        755                 760                 765             


Ser Arg Arg Arg Ser Pro Gln Glu Gly Pro Thr Trp Ser Arg Gly Arg 
    770                 775                 780                 


Arg Ser Pro Arg Ala Pro Gly Glu Pro Thr Pro Ala Ser Phe Phe Ile 
785                 790                 795                 800 


Gly Asp Gln Asn Gly Asp Ala Val Leu Ser Arg Lys Pro Leu Ala Ala 
                805                 810                 815     


Pro Gly Asp Gly Glu Gly Leu Gly Gln Thr Ala Gln Pro Ser Pro Pro 
            820                 825                 830         


Ala Arg Asp Gly Val Tyr Val Ser Ala Asn Gly Arg Met Val Ile Gln 
        835                 840                 845             


Leu Arg Pro Gly Arg Ser Pro Glu Pro Asp Gly Pro Ala Pro Ala Phe 
    850                 855                 860                 


Leu Arg Gln Glu Ser Phe Thr Lys Glu Pro Ala Ser Gly Pro Pro Ala 
865                 870                 875                 880 


Pro Gly Lys Pro Pro His Ile Ser Ser His Pro Leu Leu Gln Asp Leu 
                885                 890                 895     


Ala Ala Thr Arg Ala Ala Arg Met Asp Phe His Ser Gln Asp Thr His 
            900                 905                 910         


Leu Ile Leu Lys Glu Thr Glu Thr Ala Leu Ala Ala Leu Glu Ala Arg 
        915                 920                 925             


Leu Leu Ser Asn Ser Val Asp Ala Glu Cys Glu Gly Gly Ser Thr Pro 
    930                 935                 940                 


Arg Pro Pro Glu Asp Ala Leu Ser Gly Asp Ser Asp Val Asp Thr Ala 
945                 950                 955                 960 


Ser Thr Val Ser Leu Arg Ser Gly Lys Ser Gly Pro Ser Pro Thr Thr 
                965                 970                 975     


Pro Gln Pro Leu Arg Ala Gln Lys Glu Met Ser Pro Ser Pro Pro Ala 
            980                 985                 990         


Ala Gln Asp Pro Gly Gly Thr Ala  Leu Val Ser Ala Arg  Glu Gln Ser 
        995                 1000                 1005             


Ser Glu  Arg Gln His His Pro  Leu Gly Pro Thr Asp  Met Gly Arg 
    1010                 1015                 1020             


Gly Glu  Pro Val Arg Arg Ser  Ala Ile Arg Arg Gly  His Arg Pro 
    1025                 1030                 1035             


Arg Gly  Ser Leu Asp Trp Pro  Ser Glu Glu Arg Gly  Pro Val Leu 
    1040                 1045                 1050             


Ala His  Leu Pro Ser Ser Asp  Val Met Ala Ser Asn  His Glu Thr 
    1055                 1060                 1065             


Pro Glu  Ala Thr Gly Ala Gly  Arg Leu Gly Ser Arg  Arg Lys Pro 
    1070                 1075                 1080             


Ala Ala  Pro Pro Pro Ser Pro  Ala Ala Arg Glu Glu  Gln Ser Arg 
    1085                 1090                 1095             


Ser Ser  Ala Ser Ser Gln Lys  Gly Pro Gln Ala Leu  Thr Arg Ser 
    1100                 1105                 1110             


Asn Ser  Leu Ser Thr Pro Arg  Pro Thr Arg Ala Ser  Arg Leu Arg 
    1115                 1120                 1125             


Arg Ala  Arg Leu Gly Asp Ala  Ser Asp Thr Glu Ala  Ala Asp Gly 
    1130                 1135                 1140             


Glu Arg  Gly Ser Leu Gly Asn  Pro Glu Pro Val Gly  Arg Pro Ala 
    1145                 1150                 1155             


Ala Glu  Gln Ala Lys Lys Leu  Ser Arg Leu Asp Ile  Leu Ala Met 
    1160                 1165                 1170             


Pro Arg  Lys Arg Ala Gly Ser  Phe Thr Gly Thr Ser  Asp Pro Glu 
    1175                 1180                 1185             


Ala Ala  Pro Ala Arg Thr Ser  Phe Ser Gly Arg Ser  Val Glu Leu 
    1190                 1195                 1200             


Cys Cys  Ala Ser Arg Lys Pro  Thr Met Ala Glu Ala  Arg Ala Val 
    1205                 1210                 1215             


Ser Arg  Lys Ala Ala Asn Thr  Ala Thr Thr Thr Gly  Pro Arg Gln 
    1220                 1225                 1230             


Pro Phe  Ser Arg Ala Arg Ser  Gly Ser Ala Arg Tyr  Thr Ser Asn 
    1235                 1240                 1245             


Thr Arg  Arg Arg Gln Gln Gly  Ser Asp Tyr Thr Ser  Thr Ser Glu 
    1250                 1255                 1260             


Glu Glu  Tyr Gly Ser Arg His  Gly Ser Pro Lys His  Thr Arg Ser 
    1265                 1270                 1275             


His Thr  Ser Thr Ala Thr Gln  Thr Pro Arg Ala Gly  Ser Ser Ser 
    1280                 1285                 1290             


Arg Ala  Arg Ser Arg Ala Pro  Gly Pro Arg Asp Thr  Asp Asp Asp 
    1295                 1300                 1305             


Glu Glu  Glu Pro Asp Pro Tyr  Gly Phe Ile Val Gln  Thr Ala Glu 
    1310                 1315                 1320             


Ile Ala  Glu Ile Ala Arg Leu  Ser Gln Thr Leu Val  Lys Asp Val 
    1325                 1330                 1335             


Ala Ile  Leu Ala Gln Glu Ile  His Asp Val Ala Gly  Asp Gly Asp 
    1340                 1345                 1350             


Thr Leu  Gly Ser Ser Glu Pro  Ala His Ser Ala Ser  Leu Ser Asn 
    1355                 1360                 1365             


Met Pro  Ser Thr Pro Ala Ser  Thr Ile Ser Ala Arg  Glu Glu Leu 
    1370                 1375                 1380             


Val Gln  Arg Ile Pro Glu Ala  Ser Leu Asn Phe Gln  Lys Val Pro 
    1385                 1390                 1395             


Pro Gly  Ser Leu Asn Ser Arg  Asp Phe Asp Gln Asn  Met Asn Asp 
    1400                 1405                 1410             


Ser Cys  Glu Asp Ala Leu Ala  Asn Lys Thr Arg Pro  Arg Asn Arg 
    1415                 1420                 1425             


Glu Glu  Val Ile Phe Asp Asn  Leu Met Leu Asn Pro  Val Ser Gln 
    1430                 1435                 1440             


Leu Ser  Gln Ala Ile Arg Glu  Asn Thr Glu His Leu  Ala Glu Lys 
    1445                 1450                 1455             


Met Lys  Ile Leu Phe Gln Asn  Thr Gly Arg Ala Trp  Glu Asp Leu 
    1460                 1465                 1470             


Glu Ala  Arg Ile Asn Ala Glu  Asn Glu Val Pro Ile  Leu Lys Thr 
    1475                 1480                 1485             


Ser Asn  Lys Glu Ile Ser Ser  Ile Leu Lys Glu Leu  Arg Arg Val 
    1490                 1495                 1500             


Gln Lys  Gln Leu Glu Val Ile  Asn Ala Ile Val Asp  Pro Ser Gly 
    1505                 1510                 1515             


Ser Leu  Asp Leu Leu Thr Gly  Asn Arg Ser Leu Ala  Ser Ser Ala 
    1520                 1525                 1530             


Gln Pro  Gly Leu Gly Lys Gly  Arg Val Ala Ala Gln  Ser Pro Pro 
    1535                 1540                 1545             


Ser Pro  Ala Ser Ala Glu Ala  Leu Leu Pro Ala Leu  Pro Leu Arg 
    1550                 1555                 1560             


Asn Phe  Pro Gln Arg Ala Ser  Cys Gly Pro Pro Ser  Leu Pro Asp 
    1565                 1570                 1575             


Pro Thr  Phe Leu Pro Asp Ala  Glu Arg Phe Leu Ile  
    1580                 1585                 1590 


<210> 8099
<211> 483
<212> PRT
<213> Homo sapiens

<400> 8099
Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg 
1               5                   10                  15      


Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly 
        35                  40                  45              


Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser 
    50                  55                  60                  


Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp 
                85                  90                  95      


Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu 
            100                 105                 110         


Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly 
        115                 120                 125             


Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu 
    130                 135                 140                 


Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu 
145                 150                 155                 160 


Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg 
                165                 170                 175     


Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn 
            180                 185                 190         


Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His 
        195                 200                 205             


Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr 
    210                 215                 220                 


Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val 
225                 230                 235                 240 


Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr 
                245                 250                 255     


Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg 
            260                 265                 270         


Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro 
        275                 280                 285             


Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp 
    290                 295                 300                 


Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe 
305                 310                 315                 320 


Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu 
                325                 330                 335     


Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr 
            340                 345                 350         


Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe 
        355                 360                 365             


Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu 
    370                 375                 380                 


Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His 
385                 390                 395                 400 


Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn 
                405                 410                 415     


Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile 
            420                 425                 430         


Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro 
        435                 440                 445             


Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr 
    450                 455                 460                 


Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr 
465                 470                 475                 480 


Asn Ser Ser 
            


<210> 8100
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8100
Met Gly Gly Ala Glu Ala Glu Pro Trp Gly Arg Ala Pro Gly Pro Ala 
1               5                   10                  15      


Ile Gly Gly Arg Arg Ala Gly Asp Ser Cys Pro Gly Trp Arg Arg Arg 
            20                  25                  30          


Ser Arg Ser Arg Gly Arg Gly Gln Arg Leu Ser His Gly Pro Arg Arg 
        35                  40                  45              


Arg Pro Gln Leu Leu Thr Ala Ala Pro Pro Leu Gln Ala Arg Gly Ala 
    50                  55                  60                  


Phe Arg Ser Phe Pro His Ser Trp Gly Glu Asp Phe Leu Ala Ser Leu 
65                  70                  75                  80  


Met Phe Lys Ile Gln Leu Glu Pro Leu Lys Leu Arg Ala Trp Thr Leu 
                85                  90                  95      


Asn Gly Phe Val Lys Phe Arg Asn Lys Glu Thr Ser Ala Gly Pro Val 
            100                 105                 110         


Ala Val Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly 
        115                 120                 125             


Ala Asn Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys 
    130                 135                 140                 


Tyr His Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys 
145                 150                 155                 160 


Glu Ile Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly 
                165                 170                 175     


Leu Tyr Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr 
            180                 185                 190         


Ser Gly Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro 
        195                 200                 205             


His Ala Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile 
    210                 215                 220                 


Phe Phe Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro 
225                 230                 235                 240 


Asp Asp Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly 
                245                 250                 255     


Arg Phe Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu 
            260                 265                 270         


Pro Leu Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu 
        275                 280                 285             


Leu Arg Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met 
    290                 295                 300                 


Lys Ile Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr 
305                 310                 315                 320 


Glu Asp Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly 
                325                 330                 335     


Thr Lys Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile 
            340                 345                 350         


Pro Ala Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe 
        355                 360                 365             


Arg Arg Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys 
    370                 375                 380                 


Glu Ala Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg 
385                 390                 395                 400 


Val Ile Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys 
                405                 410                 415     


Arg Leu Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg 
            420                 425                 430         


Gly Asp Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr 
        435                 440                 445             


Pro Gln Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
    450                 455                 460         


<210> 8101
<211> 92
<212> PRT
<213> Homo sapiens

<400> 8101
Val Tyr Gly Ala Lys Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys 
1               5                   10                  15      


Ile Asp Arg Tyr Thr Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met 
            20                  25                  30          


Ala Lys Thr His Leu Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val 
        35                  40                  45              


Pro Arg Asp Phe Ile Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly 
    50                  55                  60                  


Ala Gly Phe Ile Tyr Pro Leu Val Gly Thr Arg Ser Ser Pro Leu Ala 
65                  70                  75                  80  


Leu Val Gly Glu Ser Gln Pro Lys Gln Val His Pro 
                85                  90          


<210> 8102
<211> 155
<212> PRT
<213> Homo sapiens

<400> 8102
Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val His Leu Ser 
145                 150                 155 


<210> 8103
<211> 160
<212> PRT
<213> Homo sapiens

<400> 8103
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 8104
<211> 219
<212> PRT
<213> Homo sapiens

<400> 8104
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Thr Thr Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Thr Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro Pro Ser Phe Asn Leu His 
            100                 105                 110         


Pro Ala Pro His Leu Leu Ala Ser Met His Leu Gln Lys Leu Asn Ser 
        115                 120                 125             


Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro Gly Gln Pro Gly Glu Ala 
    130                 135                 140                 


Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala Gln Ala Gly Gly Ala Glu 
145                 150                 155                 160 


Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser Pro Ala Ile Ile Asp Ser 
                165                 170                 175     


Asp Pro Val Asp Glu Glu Val Leu Met Ser Leu Val Val Glu Leu Gly 
            180                 185                 190         


Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu 
        195                 200                 205             


Phe Asp Phe Thr Ala Asp Phe Pro Ser Ser Cys 
    210                 215                 


<210> 8105
<211> 105
<212> PRT
<213> Homo sapiens

<400> 8105
Met Asn Met Ile Trp Arg Asn Ser Ile Ser Cys Leu Arg Leu Gly Lys 
1               5                   10                  15      


Val Pro His Arg Tyr Gln Ser Gly Tyr His Pro Val Ala Pro Leu Gly 
            20                  25                  30          


Ser Arg Ile Leu Thr Asp Pro Ala Lys Val Phe Glu His Asn Met Trp 
        35                  40                  45              


Asp His Met Gln Trp Ser Lys Glu Glu Glu Ala Ala Ala Arg Lys Lys 
    50                  55                  60                  


Val Lys Glu Asn Ser Ala Val Arg Val Leu Leu Glu Glu Gln Val Lys 
65                  70                  75                  80  


Tyr Glu Arg Glu Ala Ser Lys Tyr Trp Asp Thr Phe Tyr Lys Ile His 
                85                  90                  95      


Lys Asn Lys Phe Phe Lys Asp Arg Asn 
            100                 105 


<210> 8106
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8106
Xaa Glu Gly Glu Ser Pro Thr Ala Ser Pro His Ser Ser Ala Thr Asp 
1               5                   10                  15      


Asp Leu His His Ser Asp Arg Tyr Gln Thr Phe Leu Arg Val Arg Ala 
            20                  25                  30          


Asn Arg Gln Thr Arg Leu Asn Ala Arg Ile Gly Lys Met Lys Arg Arg 
        35                  40                  45              


Lys Gln Asp Glu Gly Gln Val Cys Pro Leu Cys Asn Arg Pro Leu Ala 
    50                  55                  60                  


Gly Ser Glu Gln Glu Met Ser Arg His Val Glu His Cys Leu Ser Lys 
65                  70                  75                  80  


Arg Glu Gly Ser Cys Met Ala Glu Asp Asp Ala Val Asp Ile Glu His 
                85                  90                  95      


Glu Asn Asn Asn Arg Phe Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg 
            100                 105                 110         


Ile Arg Ala Thr Thr Leu Leu Glu Gly 
        115                 120     


<210> 8107
<211> 566
<212> PRT
<213> Homo sapiens

<400> 8107
Met Asp Leu His Arg Ala Ala Phe Lys Met Glu Asn Ser Ser Tyr Leu 
1               5                   10                  15      


Pro Asn Pro Leu Ala Ser Pro Ala Leu Met Val Leu Ala Ser Thr Ala 
            20                  25                  30          


Glu Ala Ser Arg Asp Ala Ser Ile Pro Cys Gln Gln Pro Arg Pro Phe 
        35                  40                  45              


Gly Val Pro Val Ser Val Asp Lys Asp Val His Ile Pro Phe Thr Asn 
    50                  55                  60                  


Gly Ser Tyr Thr Phe Ala Ser Met Tyr His Arg Gln Gly Gly Val Pro 
65                  70                  75                  80  


Gly Thr Phe Ala Asn Arg Asp Phe Pro Pro Ser Leu Leu His Leu His 
                85                  90                  95      


Pro Gln Phe Ala Pro Pro Asn Leu Asp Cys Thr Pro Ile Ser Met Leu 
            100                 105                 110         


Asn His Ser Gly Val Gly Ala Phe Arg Pro Phe Ala Ser Thr Glu Asp 
        115                 120                 125             


Arg Glu Ser Tyr Gln Ser Ala Phe Thr Pro Ala Lys Arg Leu Lys Asn 
    130                 135                 140                 


Cys His Asp Thr Glu Ser Pro His Leu Arg Phe Ser Asp Ala Asp Gly 
145                 150                 155                 160 


Lys Glu Tyr Asp Phe Gly Thr Gln Leu Pro Ser Ser Ser Pro Gly Ser 
                165                 170                 175     


Leu Lys Val Asp Asp Thr Gly Lys Lys Ile Phe Ala Val Ser Gly Leu 
            180                 185                 190         


Ile Ser Asp Arg Glu Ala Ser Ser Ser Pro Glu Asp Arg Asn Asp Arg 
        195                 200                 205             


Cys Lys Lys Lys Ala Ala Ala Leu Phe Asp Ser Gln Ala Pro Ile Cys 
    210                 215                 220                 


Pro Ile Cys Gln Val Leu Leu Arg Pro Ser Glu Leu Gln Glu His Met 
225                 230                 235                 240 


Glu Gln Glu Leu Glu Gln Leu Ala Gln Leu Pro Ser Ser Lys Asn Ser 
                245                 250                 255     


Leu Leu Lys Asp Ala Met Ala Pro Gly Thr Pro Lys Ser Leu Leu Leu 
            260                 265                 270         


Ser Ala Ser Ile Lys Arg Glu Gly Glu Ser Pro Thr Ala Ser Pro His 
        275                 280                 285             


Ser Ser Ala Thr Asp Asp Leu His His Ser Asp Arg Tyr Gln Thr Phe 
    290                 295                 300                 


Leu Arg Val Arg Ala Asn Arg Gln Thr Arg Leu Asn Ala Arg Ile Gly 
305                 310                 315                 320 


Lys Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Arg Glu Gly Ser Cys 
                325                 330                 335     


Met Ala Glu Asp Asp Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg 
            340                 345                 350         


Phe Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr 
        355                 360                 365             


Leu Leu Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly 
    370                 375                 380                 


Lys Glu Asn Pro Asp Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp 
385                 390                 395                 400 


Thr Leu Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro 
                405                 410                 415     


Cys Thr Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg 
            420                 425                 430         


Gly Ala Val Leu Asn Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu 
        435                 440                 445             


Phe Ser Lys Trp Ala Ser Asp Glu Met Pro Ser Thr Ser Asn Gly Glu 
    450                 455                 460                 


Ser Ser Lys Gln Glu Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile 
465                 470                 475                 480 


Glu Lys Ile Thr Glu Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys 
                485                 490                 495     


Ala Arg Val Arg Glu Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr 
            500                 505                 510         


Lys Cys Leu Ile Cys Met Asp Ser Tyr Ser Met Pro Leu Thr Ser Ile 
        515                 520                 525             


Gln Cys Trp His Val His Cys Glu Glu Cys Trp Leu Arg Thr Leu Gly 
    530                 535                 540                 


Ala Lys Lys Leu Cys Pro Gln Cys Asn Thr Ile Thr Ala Pro Gly Asp 
545                 550                 555                 560 


Leu Arg Arg Ile Tyr Leu 
                565     


<210> 8108
<211> 1572
<212> PRT
<213> Homo sapiens

<400> 8108
Met Leu Leu His Leu Cys Ser Val Lys Asn Leu Tyr Gln Asn Arg Phe 
1               5                   10                  15      


Leu Gly Leu Ala Ala Met Ala Ser Pro Ser Arg Asn Ser Gln Ser Arg 
            20                  25                  30          


Arg Arg Cys Lys Glu Pro Leu Arg Tyr Ser Tyr Asn Pro Asp Gln Phe 
        35                  40                  45              


His Asn Met Asp Leu Arg Gly Gly Pro His Asp Gly Val Thr Ile Pro 
    50                  55                  60                  


Arg Ser Thr Ser Asp Thr Asp Leu Val Thr Ser Asp Ser Arg Ser Thr 
65                  70                  75                  80  


Leu Met Val Ser Ser Ser Tyr Tyr Ser Ile Gly His Ser Gln Asp Leu 
                85                  90                  95      


Val Ile His Trp Asp Ile Lys Glu Glu Val Asp Ala Gly Asp Trp Ile 
            100                 105                 110         


Gly Met Tyr Leu Ile Asp Glu Val Leu Ser Glu Asn Phe Leu Asp Tyr 
        115                 120                 125             


Lys Asn Arg Gly Val Asn Gly Ser His Arg Gly Gln Ile Ile Trp Lys 
    130                 135                 140                 


Ile Asp Ala Ser Ser Tyr Phe Val Glu Pro Glu Thr Lys Ile Cys Phe 
145                 150                 155                 160 


Lys Tyr Tyr His Gly Val Ser Gly Ala Leu Arg Ala Thr Thr Pro Ser 
                165                 170                 175     


Val Thr Val Lys Asn Ser Ala Ala Pro Ile Phe Lys Ser Ile Gly Ala 
            180                 185                 190         


Asp Glu Thr Val Gln Gly Gln Gly Ser Arg Arg Leu Ile Ser Phe Ser 
        195                 200                 205             


Leu Ser Asp Phe Gln Ala Met Gly Leu Lys Lys Gly Met Phe Phe Asn 
    210                 215                 220                 


Pro Asp Pro Tyr Leu Lys Ile Ser Ile Gln Pro Gly Lys His Ser Ile 
225                 230                 235                 240 


Phe Pro Ala Leu Pro His His Gly Gln Glu Arg Arg Ser Lys Ile Ile 
                245                 250                 255     


Gly Asn Thr Val Asn Pro Ile Trp Gln Ala Glu Gln Phe Ser Phe Val 
            260                 265                 270         


Ser Leu Pro Thr Asp Val Leu Glu Ile Glu Val Lys Asp Lys Phe Ala 
        275                 280                 285             


Lys Ser Arg Pro Ile Ile Lys Arg Phe Leu Gly Lys Leu Ser Met Pro 
    290                 295                 300                 


Val Gln Arg Leu Leu Glu Arg His Ala Ile Gly Asp Arg Val Val Ser 
305                 310                 315                 320 


Tyr Thr Leu Gly Arg Arg Leu Pro Thr Asp His Val Ser Gly Gln Leu 
                325                 330                 335     


Gln Phe Arg Phe Glu Ile Thr Ser Ser Ile His Pro Asp Asp Glu Glu 
            340                 345                 350         


Ile Ser Leu Ser Thr Glu Pro Glu Ser Ala Gln Ile Gln Asp Ser Pro 
        355                 360                 365             


Met Asn Asn Leu Met Glu Ser Gly Ser Gly Glu Pro Arg Ser Glu Ala 
    370                 375                 380                 


Pro Glu Ser Ser Glu Ser Trp Lys Pro Glu Gln Leu Gly Glu Gly Ser 
385                 390                 395                 400 


Val Pro Asp Gly Pro Gly Asn Gln Ser Ile Glu Leu Ser Arg Pro Ala 
                405                 410                 415     


Glu Glu Ala Ala Val Ile Thr Glu Ala Gly Asp Gln Gly Met Val Ser 
            420                 425                 430         


Val Gly Pro Glu Gly Ala Gly Glu Leu Leu Ala Gln Val Gln Lys Asp 
        435                 440                 445             


Ile Gln Pro Ala Pro Ser Ala Glu Glu Leu Ala Glu Gln Leu Asp Leu 
    450                 455                 460                 


Gly Glu Glu Ala Ser Ala Leu Leu Leu Glu Asp Gly Glu Ala Pro Ala 
465                 470                 475                 480 


Ser Thr Lys Glu Glu Pro Leu Glu Glu Glu Ala Thr Thr Gln Ser Arg 
                485                 490                 495     


Ala Gly Arg Glu Glu Glu Glu Lys Glu Gln Glu Glu Glu Gly Asp Val 
            500                 505                 510         


Ser Thr Leu Glu Gln Gly Glu Gly Arg Leu Gln Leu Arg Ala Ser Val 
        515                 520                 525             


Lys Arg Lys Ser Arg Pro Cys Ser Leu Pro Val Ser Glu Leu Glu Thr 
    530                 535                 540                 


Val Ile Ala Ser Ala Cys Gly Asp Pro Glu Thr Pro Arg Thr His Tyr 
545                 550                 555                 560 


Ile Arg Ile His Thr Leu Leu His Ser Met Pro Ser Ala Gln Gly Gly 
                565                 570                 575     


Ser Ala Ala Glu Glu Glu Asp Gly Ala Glu Glu Glu Ser Thr Leu Lys 
            580                 585                 590         


Asp Ser Ser Glu Lys Asp Gly Leu Ser Glu Val Asp Thr Val Ala Ala 
        595                 600                 605             


Asp Pro Ser Ala Leu Glu Glu Asp Arg Glu Glu Pro Glu Gly Ala Thr 
    610                 615                 620                 


Pro Gly Thr Ala His Pro Gly His Ser Gly Gly His Phe Pro Ser Leu 
625                 630                 635                 640 


Ala Asn Gly Ala Ala Gln Asp Gly Asp Thr His Pro Ser Thr Gly Ser 
                645                 650                 655     


Glu Ser Asp Ser Ser Pro Arg Gln Gly Gly Asp His Ser Cys Glu Gly 
            660                 665                 670         


Cys Asp Ala Ser Cys Cys Ser Pro Ser Cys Tyr Ser Ser Ser Cys Tyr 
        675                 680                 685             


Ser Thr Ser Cys Tyr Ser Ser Ser Cys Tyr Ser Ala Ser Cys Tyr Ser 
    690                 695                 700                 


Pro Ser Cys Tyr Asn Gly Asn Arg Phe Ala Ser His Thr Arg Phe Ser 
705                 710                 715                 720 


Ser Val Asp Ser Ala Lys Ile Ser Glu Ser Thr Val Phe Ser Ser Gln 
                725                 730                 735     


Asp Asp Glu Glu Glu Glu Asn Ser Ala Phe Glu Ser Val Pro Asp Ser 
            740                 745                 750         


Met Gln Ser Pro Glu Leu Asp Pro Glu Ser Thr Asn Gly Ala Gly Pro 
        755                 760                 765             


Trp Gln Asp Glu Leu Ala Ala Pro Ser Gly His Val Glu Arg Ser Pro 
    770                 775                 780                 


Glu Gly Leu Glu Ser Pro Val Ala Gly Pro Ser Asn Arg Arg Glu Asp 
785                 790                 795                 800 


Trp Glu Ala Arg Ile Asp Ser His Gly Arg Val Phe Tyr Val Asp His 
                805                 810                 815     


Val Asn Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Ala Ala Thr Pro 
            820                 825                 830         


Asp Gly Met Arg Arg Ser Gly Ser Ile Gln Gln Met Glu Gln Leu Asn 
        835                 840                 845             


Arg Arg Tyr Gln Asn Ile Gln Arg Thr Ile Ala Thr Glu Arg Ser Glu 
    850                 855                 860                 


Glu Asp Ser Gly Ser Gln Ser Cys Glu Gln Ala Pro Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Gly Gly Ser Asp Ser Glu Ala Glu Ser Ser Gln Ser Ser Leu 
                885                 890                 895     


Asp Leu Arg Arg Glu Gly Ser Leu Ser Pro Val Asn Ser Gln Lys Ile 
            900                 905                 910         


Thr Leu Leu Leu Gln Ser Pro Ala Val Lys Phe Ile Thr Asn Pro Glu 
        915                 920                 925             


Phe Phe Thr Val Leu His Ala Asn Tyr Ser Ala Tyr Arg Val Phe Thr 
    930                 935                 940                 


Ser Ser Thr Cys Leu Lys His Met Ile Leu Lys Val Arg Arg Asp Ala 
945                 950                 955                 960 


Arg Asn Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Asn Phe Ile 
                965                 970                 975     


Asn Met Phe Ala Asp Thr Arg Leu Glu Leu Pro Arg Gly Trp Glu Ile 
            980                 985                 990         


Lys Thr Asp Gln Gln Gly Lys Ser  Phe Phe Val Asp His  Asn Ser Arg 
        995                 1000                 1005             


Ala Thr  Thr Phe Ile Asp Pro  Arg Ile Pro Leu Gln  Asn Gly Arg 
    1010                 1015                 1020             


Leu Pro  Asn His Leu Thr His  Arg Gln His Leu Gln  Arg Leu Arg 
    1025                 1030                 1035             


Ser Tyr  Ser Ala Gly Glu Ala  Ser Glu Val Ser Arg  Asn Arg Gly 
    1040                 1045                 1050             


Ala Ser  Leu Leu Ala Arg Pro  Gly His Ser Leu Val  Ala Ala Ile 
    1055                 1060                 1065             


Arg Ser  Gln His Gln His Glu  Ser Leu Pro Leu Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Met Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Ser Leu  Ala Arg Asn His Thr  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  His Tyr Ile Arg Thr  Glu Gly Asn His Gly  Leu Glu Lys 
    1115                 1120                 1125             


Leu Ser  Cys Asp Ala Asp Leu  Val Ile Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Leu Gln Ala Ala  Phe His Pro 
    1145                 1150                 1155             


Gly Tyr  Ser Phe Ser Pro Arg  Cys Ser Pro Cys Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Leu Gln Arg  Ala Ser Ala Arg Ala  Pro Ser Pro 
    1175                 1180                 1185             


Tyr Arg  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Ala Lys Gly Phe Gly  Gln Gly Pro Gly Lys  Ile Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Gly Thr Phe  Asn Gln Val 
    1220                 1225                 1230             


Met Ala  Tyr Ser Arg Lys Glu  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Leu Ser  Gln Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Glu Asn His Leu Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Leu Pro  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asn Ile  Thr Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Val 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Ser  Gly Gly Ala Asn Thr  Gln Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Val Glu  Arg Gly Val Val Gln  Gln Thr Glu Ala Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ser  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Asn Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Gly His  Leu Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Val Pro Tyr Glu Gly  Phe Ala Ala Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Leu  Arg Arg Phe Cys Ile  Glu Lys Trp Gly Lys  Ile Thr Ser 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Tyr Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         


<210> 8109
<211> 542
<212> PRT
<213> Homo sapiens

<400> 8109
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu Ala Gln Glu Glu Lys Glu Gly Asp Ala Thr Lys Asp 
                85                  90                  95      


Ser Leu Asp Asp Leu Phe Pro Asn Glu Glu Glu Glu Asp Pro Ser Asn 
            100                 105                 110         


Gly Leu Ser Arg Gly Gln Gly Ala Thr Ala Ala Gln Gln Gly Gly Tyr 
        115                 120                 125             


Glu Ile Pro Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr 
    130                 135                 140                 


Ala Ala Gln Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Asp Leu Glu Arg Thr Ser Gly Arg Gly His Pro Asp Val Ala 
                165                 170                 175     


Thr Met Leu Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr 
            180                 185                 190         


Lys Glu Ala Ala His Leu Leu Asn Asp Ala Leu Ser Ile Arg Glu Ser 
        195                 200                 205             


Thr Leu Gly Pro Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu 
    210                 215                 220                 


Ala Val Leu Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu 
225                 230                 235                 240 


Cys Gln Arg Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Thr Asn His 
                245                 250                 255     


Pro Asp Val Ala Lys Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn 
            260                 265                 270         


Gln Gly Lys Tyr Glu Ala Val Glu Arg Tyr Tyr Gln Arg Ala Leu Ala 
        275                 280                 285             


Ile Tyr Glu Gly Gln Leu Gly Pro Asp Asn Pro Asn Val Ala Arg Thr 
    290                 295                 300                 


Lys Asn Asn Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Tyr Ala Glu 
305                 310                 315                 320 


Ala Glu Thr Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Val Gln Glu 
                325                 330                 335     


Phe Gly Ser Val Asp Asp Asp His Lys Pro Ile Trp Met His Ala Glu 
            340                 345                 350         


Glu Arg Glu Glu Met Ser Lys Ser Arg His His Glu Gly Gly Thr Pro 
        355                 360                 365             


Tyr Ala Glu Tyr Gly Gly Trp Tyr Lys Ala Cys Lys Val Ser Ser Pro 
    370                 375                 380                 


Thr Val Asn Thr Thr Leu Arg Asn Leu Gly Ala Leu Tyr Arg Arg Gln 
385                 390                 395                 400 


Gly Lys Leu Glu Ala Ala Glu Thr Leu Glu Glu Cys Ala Leu Arg Ser 
                405                 410                 415     


Arg Arg Gln Gly Thr Asp Pro Ile Ser Gln Thr Lys Val Ala Glu Leu 
            420                 425                 430         


Leu Gly Glu Ser Asp Gly Arg Arg Thr Ser Gln Glu Gly Pro Gly Asp 
        435                 440                 445             


Ser Val Lys Phe Glu Gly Gly Glu Asp Ala Ser Val Ala Val Glu Trp 
    450                 455                 460                 


Ser Gly Asp Gly Ser Gly Thr Leu Gln Arg Ser Gly Ser Leu Gly Lys 
465                 470                 475                 480 


Ile Arg Asp Val Leu Arg Arg Ser Ser Glu Leu Leu Val Arg Lys Leu 
                485                 490                 495     


Gln Gly Thr Glu Pro Arg Pro Ser Ser Ser Asn Met Lys Arg Ala Ala 
            500                 505                 510         


Ser Leu Asn Tyr Leu Asn Gln Pro Ser Ala Ala Pro Leu Gln Val Ser 
        515                 520                 525             


Arg Gly Leu Ser Ala Ser Thr Met Asp Leu Ser Ser Ser Ser 
    530                 535                 540         


<210> 8110
<211> 515
<212> PRT
<213> Homo sapiens

<400> 8110
Met Cys Gln Val Gly Glu Asp Tyr Gly Glu Pro Ala Pro Glu Glu Pro 
1               5                   10                  15      


Pro Pro Ala Pro Arg Pro Ser Arg Glu Gln Lys Cys Val Lys Cys Lys 
            20                  25                  30          


Glu Ala Gln Pro Val Val Val Ile Arg Ala Gly Asp Ala Phe Cys Arg 
        35                  40                  45              


Asp Cys Phe Lys Ala Phe Tyr Val His Lys Phe Arg Ala Met Leu Gly 
    50                  55                  60                  


Lys Asn Arg Leu Ile Phe Pro Gly Glu Lys Val Leu Leu Ala Trp Ser 
65                  70                  75                  80  


Gly Gly Pro Ser Ser Ser Ser Met Val Trp Gln Val Leu Glu Gly Leu 
                85                  90                  95      


Ser Gln Asp Ser Ala Lys Arg Leu Arg Phe Val Ala Gly Val Ile Phe 
            100                 105                 110         


Val Asp Glu Gly Ala Ala Cys Gly Gln Ser Leu Glu Glu Arg Ser Lys 
        115                 120                 125             


Thr Leu Ala Glu Val Lys Pro Ile Leu Gln Ala Thr Gly Phe Pro Trp 
    130                 135                 140                 


His Val Val Ala Leu Glu Glu Val Phe Ser Leu Pro Pro Ser Val Leu 
145                 150                 155                 160 


Trp Cys Ser Ala Gln Glu Leu Val Gly Ser Glu Gly Ala Tyr Lys Ala 
                165                 170                 175     


Ala Val Asp Ser Phe Leu Gln Gln Gln His Val Leu Gly Ala Gly Gly 
            180                 185                 190         


Gly Pro Gly Pro Thr Gln Gly Glu Glu Gln Pro Pro Gln Pro Pro Leu 
        195                 200                 205             


Asp Pro Gln Asn Leu Ala Arg Pro Pro Ala Pro Ala Gln Thr Glu Ala 
    210                 215                 220                 


Leu Ser Gln Leu Phe Cys Ser Val Arg Thr Leu Thr Ala Lys Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Thr Leu Arg Thr His Leu Ile Leu His Met Ala Arg Ala 
                245                 250                 255     


His Gly Tyr Ser Lys Val Met Thr Gly Asp Ser Cys Thr Arg Leu Ala 
            260                 265                 270         


Ile Lys Leu Met Thr Asn Leu Ala Leu Gly Arg Gly Ala Phe Leu Ala 
        275                 280                 285             


Trp Asp Thr Gly Phe Ser Asp Glu Arg His Gly Asp Val Val Val Val 
    290                 295                 300                 


Arg Pro Met Arg Asp His Thr Leu Lys Glu Val Ala Phe Tyr Asn Arg 
305                 310                 315                 320 


Leu Phe Ser Val Pro Ser Val Phe Thr Pro Ala Val Asp Thr Lys Ala 
                325                 330                 335     


Pro Glu Lys Ala Ser Ile His Arg Leu Met Glu Ala Phe Ile Leu Arg 
            340                 345                 350         


Leu Gln Thr Gln Phe Pro Ser Thr Val Ser Thr Val Tyr Arg Thr Ser 
        355                 360                 365             


Glu Lys Leu Val Lys Gly Pro Arg Asp Gly Pro Ala Ala Gly Asp Ser 
    370                 375                 380                 


Gly Pro Arg Cys Leu Leu Cys Met Cys Ala Leu Asp Val Asp Ala Ala 
385                 390                 395                 400 


Asp Ser Ala Thr Ala Phe Gly Ala Gln Thr Ser Ser Arg Leu Ser Gln 
                405                 410                 415     


Met Gln Ser Pro Ile Pro Leu Thr Glu Thr Arg Thr Pro Pro Gly Pro 
            420                 425                 430         


Cys Cys Ser Pro Gly Val Gly Trp Ala Gln Arg Cys Gly Gln Gly Ala 
        435                 440                 445             


Cys Arg Arg Glu Asp Pro Gln Ala Cys Ile Glu Glu Gln Leu Cys Tyr 
    450                 455                 460                 


Ser Cys Arg Val Asn Met Lys Asp Leu Pro Ser Leu Asp Pro Leu Pro 
465                 470                 475                 480 


Pro Tyr Ile Leu Ala Glu Ala Gln Leu Arg Thr Gln Arg Ala Trp Gly 
                485                 490                 495     


Leu Gln Glu Ile Arg Asp Cys Leu Ile Glu Asp Ser Asp Asp Glu Ala 
            500                 505                 510         


Gly Gln Ser 
        515 


<210> 8111
<211> 420
<212> PRT
<213> Homo sapiens

<400> 8111
Met Phe Lys Arg Thr Val Leu Ser Cys Pro Pro Pro Ala Ala Pro Pro 
1               5                   10                  15      


Leu Gln Ala Arg Gly Ala Phe Arg Ser Phe Pro His Ser Trp Gly Glu 
            20                  25                  30          


Asp Phe Leu Ala Ser Leu Met Phe Lys Ile Gln Leu Glu Pro Leu Lys 
        35                  40                  45              


Leu Arg Ala Trp Thr Leu Asn Gly Phe Val Lys Phe Arg Asn Lys Glu 
    50                  55                  60                  


Thr Ser Ala Gly Pro Val Ala Val Met Gly Lys Asp Tyr Tyr Lys Ile 
65                  70                  75                  80  


Leu Gly Ile Pro Ser Gly Ala Asn Glu Asp Glu Ile Lys Lys Ala Tyr 
                85                  90                  95      


Arg Lys Met Ala Leu Lys Tyr His Pro Asp Lys Asn Lys Glu Pro Asn 
            100                 105                 110         


Ala Glu Glu Lys Phe Lys Glu Ile Ala Glu Ala Tyr Asp Val Leu Ser 
        115                 120                 125             


Asp Pro Lys Lys Arg Gly Leu Tyr Asp Gln Tyr Gly Glu Glu Gly Leu 
    130                 135                 140                 


Lys Thr Gly Gly Gly Thr Ser Gly Gly Ser Ser Gly Ser Phe His Tyr 
145                 150                 155                 160 


Thr Phe His Gly Asp Pro His Ala Thr Phe Ala Ser Phe Phe Gly Gly 
                165                 170                 175     


Ser Asn Pro Phe Asp Ile Phe Phe Ala Ser Ser Arg Ser Thr Arg Pro 
            180                 185                 190         


Phe Ser Gly Phe Asp Pro Asp Asp Met Asp Val Asp Glu Asp Glu Asp 
        195                 200                 205             


Pro Phe Gly Ala Phe Gly Arg Phe Gly Phe Asn Gly Leu Ser Arg Gly 
    210                 215                 220                 


Pro Arg Arg Ala Pro Glu Pro Leu Tyr Pro Arg Arg Lys Val Gln Asp 
225                 230                 235                 240 


Pro Pro Val Val His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr His 
                245                 250                 255     


Gly Ser Thr Lys Arg Met Lys Ile Thr Arg Arg Arg Leu Asn Pro Asp 
            260                 265                 270         


Gly Arg Thr Val Arg Thr Glu Asp Lys Ile Leu His Ile Val Ile Lys 
        275                 280                 285             


Arg Gly Trp Lys Glu Gly Thr Lys Ile Thr Phe Pro Lys Glu Gly Asp 
    290                 295                 300                 


Ala Thr Pro Asp Asn Ile Pro Ala Asp Ile Val Phe Val Leu Lys Asp 
305                 310                 315                 320 


Lys Pro His Ala His Phe Arg Arg Asp Gly Thr Asn Val Leu Tyr Ser 
                325                 330                 335     


Ala Leu Ile Ser Leu Lys Glu Ala Leu Cys Gly Cys Thr Val Asn Ile 
            340                 345                 350         


Pro Thr Ile Asp Gly Arg Val Ile Pro Leu Pro Cys Asn Asp Val Ile 
        355                 360                 365             


Lys Pro Gly Thr Val Lys Arg Leu Arg Gly Glu Gly Leu Pro Phe Pro 
    370                 375                 380                 


Lys Val Pro Thr Gln Arg Gly Asp Leu Ile Val Glu Phe Lys Val Arg 
385                 390                 395                 400 


Phe Pro Asp Arg Leu Thr Pro Gln Thr Arg Gln Ile Leu Lys Gln His 
                405                 410                 415     


Leu Pro Cys Ser 
            420 


<210> 8112
<211> 992
<212> PRT
<213> Homo sapiens

<400> 8112
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Ile Gly Gln Val Lys Gln Glu Leu Ser 
        435                 440                 445             


Arg Lys Asp Thr Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu 
    450                 455                 460                 


Thr Asn Gln Phe Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Thr Ala Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val 
                485                 490                 495     


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
            500                 505                 510         


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
        515                 520                 525             


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
    530                 535                 540                 


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
545                 550                 555                 560 


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
                565                 570                 575     


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
            580                 585                 590         


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
        595                 600                 605             


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
    610                 615                 620                 


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
625                 630                 635                 640 


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
                645                 650                 655     


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
            660                 665                 670         


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
        675                 680                 685             


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
    690                 695                 700                 


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
705                 710                 715                 720 


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
                725                 730                 735     


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
            740                 745                 750         


Glu Leu Glu Ser Leu Phe Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
        755                 760                 765             


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
    770                 775                 780                 


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
785                 790                 795                 800 


Ser Gln Gln Leu Gln Asp Ser Leu Arg Lys Lys Asp Asp Arg Ile Glu 
                805                 810                 815     


Glu Leu Glu Glu Ala Leu Arg Glu Ser Val Gln Ile Thr Ala Glu Arg 
            820                 825                 830         


Glu Met Val Leu Ala Gln Glu Glu Ser Ala Arg Thr Asn Ala Glu Lys 
        835                 840                 845             


Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val Lys Gln Glu Leu 
    850                 855                 860                 


Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln Ser Leu Ala Glu 
865                 870                 875                 880 


Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg Arg Lys His Leu 
                885                 890                 895     


Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser 
            900                 905                 910         


Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser Ser Ser Lys Lys 
        915                 920                 925             


Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu Lys Asp Arg Leu 
    930                 935                 940                 


Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala 
945                 950                 955                 960 


Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His Ser Asn Gln Thr 
                965                 970                 975     


Asn His Lys Pro Ser Pro Asp Gln Asp Glu Glu Glu Gly Ile Trp Ala 
            980                 985                 990         


<210> 8113
<211> 59
<212> PRT
<213> Homo sapiens

<400> 8113
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Thr Thr Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Thr Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn 
    50                  55                  


<210> 8114
<211> 2325
<212> PRT
<213> Homo sapiens

<400> 8114
Met Lys Lys Gly Ser Gln Gln Lys Ile Phe Ser Lys Ala Lys Ile Pro 
1               5                   10                  15      


Ser Ser Ser His Ser Pro Ile Pro Ser Ser Met Ser Asn Met Arg Ser 
            20                  25                  30          


Arg Ser Leu Ser Pro Leu Ile Gly Ser Glu Thr Leu Pro Phe His Ser 
        35                  40                  45              


Gly Gly Gln Trp Cys Glu Gln Val Glu Ile Ala Asp Glu Asn Asn Met 
    50                  55                  60                  


Leu Leu Asp Tyr Gln Asp His Lys Gly Ala Asp Ser His Ala Gly Val 
65                  70                  75                  80  


Arg Tyr Ile Thr Glu Ala Leu Ile Lys Lys Leu Thr Lys Gln Asp Asn 
                85                  90                  95      


Leu Ala Leu Ile Lys Ser Leu Asn Leu Ser Leu Ser Lys Asp Gly Gly 
            100                 105                 110         


Lys Lys Phe Lys Tyr Ile Glu Asn Leu Glu Lys Cys Val Lys Leu Glu 
        115                 120                 125             


Val Leu Asn Leu Ser Tyr Asn Leu Ile Gly Lys Ile Glu Lys Leu Asp 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Leu Asn Leu Ser Tyr Asn Lys Ile Ser 
145                 150                 155                 160 


Lys Ile Glu Gly Ile Glu Asn Met Cys Asn Leu Gln Lys Leu Asn Leu 
                165                 170                 175     


Ala Gly Asn Glu Ile Glu His Ile Pro Val Trp Leu Gly Lys Lys Leu 
            180                 185                 190         


Lys Ser Leu Arg Val Leu Asn Leu Lys Gly Asn Lys Ile Ser Ser Leu 
        195                 200                 205             


Gln Asp Ile Ser Lys Leu Lys Pro Leu Gln Asp Leu Ile Ser Leu Ile 
    210                 215                 220                 


Leu Val Glu Asn Pro Val Val Thr Leu Pro His Tyr Leu Gln Phe Thr 
225                 230                 235                 240 


Ile Phe His Leu Arg Ser Leu Glu Ser Leu Glu Gly Gln Pro Val Thr 
                245                 250                 255     


Thr Gln Asp Arg Gln Glu Ala Phe Glu Arg Phe Ser Leu Glu Glu Val 
            260                 265                 270         


Glu Arg Leu Glu Arg Asp Leu Glu Lys Lys Met Ile Glu Thr Glu Glu 
        275                 280                 285             


Leu Lys Ser Lys Gln Thr Arg Phe Leu Glu Glu Ile Lys Asn Gln Asp 
    290                 295                 300                 


Lys Leu Asn Lys Ser Leu Lys Glu Glu Ala Met Leu Gln Lys Gln Ser 
305                 310                 315                 320 


Cys Glu Glu Leu Lys Ser Asp Leu Asn Thr Lys Asn Glu Leu Leu Lys 
                325                 330                 335     


Gln Lys Thr Ile Glu Leu Thr Arg Ala Cys Gln Lys Gln Tyr Glu Leu 
            340                 345                 350         


Glu Gln Glu Leu Ala Phe Tyr Lys Ile Asp Ala Lys Phe Glu Pro Leu 
        355                 360                 365             


Asn Tyr Tyr Pro Ser Glu Tyr Ala Glu Ile Asp Lys Ala Pro Asp Glu 
    370                 375                 380                 


Ser Pro Tyr Ile Gly Lys Ser Arg Tyr Lys Arg Asn Met Phe Ala Thr 
385                 390                 395                 400 


Glu Ser Tyr Ile Ile Asp Ser Ala Gln Ala Val Gln Ile Lys Lys Met 
                405                 410                 415     


Glu Pro Asp Glu Gln Leu Arg Asn Asp His Met Asn Leu Arg Gly His 
            420                 425                 430         


Thr Pro Leu Asp Thr Gln Leu Glu Asp Lys Glu Lys Lys Ile Ser Ala 
        435                 440                 445             


Ala Gln Thr Arg Leu Ser Glu Leu His Asp Glu Ile Glu Lys Ala Glu 
    450                 455                 460                 


Gln Gln Ile Leu Arg Ala Thr Glu Glu Phe Lys Gln Leu Glu Glu Ala 
465                 470                 475                 480 


Ile Gln Leu Lys Lys Ile Ser Glu Ala Gly Lys Asp Leu Leu Tyr Lys 
                485                 490                 495     


Gln Leu Ser Gly Arg Leu Gln Leu Val Asn Lys Leu Arg Gln Glu Ala 
            500                 505                 510         


Leu Asp Leu Glu Leu Gln Met Glu Lys Gln Lys Gln Glu Ile Ala Gly 
        515                 520                 525             


Lys Gln Lys Glu Ile Lys Asp Leu Gln Ile Ala Ile Asp Ser Leu Asp 
    530                 535                 540                 


Ser Lys Asp Pro Lys His Ser His Met Lys Ala Gln Lys Ser Gly Lys 
545                 550                 555                 560 


Glu Gln Gln Leu Asp Ile Met Asn Lys Gln Tyr Gln Gln Leu Glu Ser 
                565                 570                 575     


Arg Leu Asp Glu Ile Leu Ser Arg Ile Ala Lys Glu Thr Glu Glu Ile 
            580                 585                 590         


Lys Asp Leu Glu Glu Gln Leu Thr Glu Gly Gln Ile Ala Ala Asn Glu 
        595                 600                 605             


Ala Leu Lys Lys Asp Leu Glu Gly Val Ile Ser Gly Leu Gln Glu Tyr 
    610                 615                 620                 


Leu Gly Thr Ile Lys Gly Gln Ala Thr Gln Ala Gln Asn Glu Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Asp Glu Lys Glu Thr Leu Leu Gln Arg Leu Thr Glu Val 
                645                 650                 655     


Glu Gln Glu Arg Asp Gln Leu Glu Ile Val Ala Met Asp Ala Glu Asn 
            660                 665                 670         


Met Arg Lys Glu Leu Ala Glu Leu Glu Ser Ala Leu Gln Glu Gln His 
        675                 680                 685             


Glu Val Asn Ala Ser Leu Gln Gln Thr Gln Gly Asp Leu Ser Ala Tyr 
    690                 695                 700                 


Glu Ala Glu Leu Glu Ala Arg Leu Asn Leu Arg Asp Ala Glu Ala Asn 
705                 710                 715                 720 


Gln Leu Lys Glu Glu Leu Glu Lys Val Thr Arg Leu Thr Gln Leu Glu 
                725                 730                 735     


Gln Ser Ala Leu Gln Ala Glu Leu Glu Lys Glu Arg Gln Ala Leu Lys 
            740                 745                 750         


Asn Ala Leu Gly Lys Ala Gln Phe Ser Glu Glu Lys Glu Gln Glu Asn 
        755                 760                 765             


Ser Glu Leu His Ala Lys Leu Lys His Leu Gln Asp Asp Asn Asn Leu 
    770                 775                 780                 


Leu Lys Gln Gln Leu Lys Asp Phe Gln Asn His Leu Asn His Val Val 
785                 790                 795                 800 


Asp Gly Leu Val Arg Pro Glu Glu Val Ala Ala Arg Val Asp Glu Leu 
                805                 810                 815     


Arg Arg Lys Leu Lys Leu Gly Thr Gly Glu Met Asn Ile His Ser Pro 
            820                 825                 830         


Ser Asp Val Leu Gly Lys Ser Leu Ala Asp Leu Gln Lys Gln Phe Ser 
        835                 840                 845             


Glu Ile Leu Ala Arg Ser Lys Trp Glu Arg Asp Glu Ala Gln Val Arg 
    850                 855                 860                 


Glu Arg Lys Leu Gln Glu Glu Met Ala Leu Gln Gln Glu Lys Leu Ala 
865                 870                 875                 880 


Thr Gly Gln Glu Glu Phe Arg Gln Ala Cys Glu Arg Ala Leu Glu Ala 
                885                 890                 895     


Arg Met Asn Phe Asp Lys Arg Gln His Glu Ala Arg Ile Gln Gln Met 
            900                 905                 910         


Glu Asn Glu Ile His Tyr Leu Gln Glu Asn Leu Lys Ser Met Glu Glu 
        915                 920                 925             


Ile Gln Gly Leu Thr Asp Leu Gln Leu Gln Glu Ala Asp Glu Glu Lys 
    930                 935                 940                 


Glu Arg Ile Leu Ala Gln Leu Arg Glu Leu Glu Lys Lys Lys Lys Leu 
945                 950                 955                 960 


Glu Asp Ala Lys Ser Gln Glu Gln Val Phe Gly Leu Asp Lys Glu Leu 
                965                 970                 975     


Lys Lys Leu Lys Lys Ala Val Ala Thr Ser Asp Lys Leu Ala Thr Ala 
            980                 985                 990         


Glu Leu Thr Ile Ala Lys Asp Gln  Leu Lys Ser Leu His  Gly Thr Val 
        995                 1000                 1005             


Met Lys  Ile Asn Gln Glu Arg  Ala Glu Glu Leu Gln  Glu Ala Glu 
    1010                 1015                 1020             


Arg Phe  Ser Arg Lys Ala Ala  Gln Ala Ala Arg Asp  Leu Thr Arg 
    1025                 1030                 1035             


Ala Glu  Ala Glu Ile Glu Leu  Leu Gln Asn Leu Leu  Arg Gln Lys 
    1040                 1045                 1050             


Gly Glu  Gln Phe Arg Leu Glu  Met Glu Lys Thr Gly  Val Gly Thr 
    1055                 1060                 1065             


Gly Ala  Asn Ser Gln Val Leu  Glu Ile Glu Lys Leu  Asn Glu Thr 
    1070                 1075                 1080             


Met Glu  Arg Gln Arg Thr Glu  Ile Ala Arg Leu Gln  Asn Val Leu 
    1085                 1090                 1095             


Asp Leu  Thr Gly Ser Asp Asn  Lys Gly Gly Phe Glu  Asn Val Leu 
    1100                 1105                 1110             


Glu Glu  Ile Ala Glu Leu Arg  Arg Glu Val Ser Tyr  Gln Asn Asp 
    1115                 1120                 1125             


Tyr Ile  Ser Ser Met Ala Asp  Pro Phe Lys Arg Arg  Gly Tyr Trp 
    1130                 1135                 1140             


Tyr Phe  Met Pro Pro Pro Pro  Ser Ser Lys Val Ser  Ser His Ser 
    1145                 1150                 1155             


Ser Gln  Ala Thr Lys Asp Ser  Gly Val Gly Leu Lys  Tyr Ser Ala 
    1160                 1165                 1170             


Ser Thr  Pro Val Arg Lys Pro  Arg Pro Gly Gln Gln  Asp Gly Lys 
    1175                 1180                 1185             


Glu Gly  Ser Gln Pro Pro Pro  Ala Ser Gly Tyr Trp  Val Tyr Ser 
    1190                 1195                 1200             


Pro Ile  Arg Ser Gly Leu His  Lys Leu Phe Pro Ser  Arg Asp Ala 
    1205                 1210                 1215             


Asp Ser  Gly Gly Asp Ser Gln  Glu Glu Ser Glu Leu  Asp Asp Gln 
    1220                 1225                 1230             


Glu Glu  Pro Pro Phe Val Pro  Pro Pro Gly Tyr Met  Met Tyr Thr 
    1235                 1240                 1245             


Val Leu  Pro Asp Gly Ser Pro  Val Pro Gln Gly Met  Ala Leu Tyr 
    1250                 1255                 1260             


Ala Pro  Pro Pro Pro Leu Pro  Asn Asn Ser Arg Pro  Leu Thr Pro 
    1265                 1270                 1275             


Gly Thr  Val Val Tyr Gly Pro  Pro Pro Ala Gly Ala  Pro Met Val 
    1280                 1285                 1290             


Tyr Gly  Pro Pro Pro Pro Asn  Phe Ser Ile Pro Phe  Ile Pro Met 
    1295                 1300                 1305             


Gly Val  Leu His Cys Asn Val  Pro Glu His His Asn  Leu Glu Asn 
    1310                 1315                 1320             


Glu Val  Ser Arg Leu Glu Asp  Ile Met Gln His Leu  Lys Ser Lys 
    1325                 1330                 1335             


Lys Arg  Glu Glu Arg Trp Met  Arg Ala Ser Lys Arg  Gln Ser Glu 
    1340                 1345                 1350             


Lys Glu  Met Glu Glu Leu His  His Asn Ile Asp Asp  Leu Leu Gln 
    1355                 1360                 1365             


Glu Lys  Lys Ser Leu Glu Cys  Glu Val Glu Glu Leu  His Arg Thr 
    1370                 1375                 1380             


Val Gln  Lys Arg Gln Gln Gln  Lys Asp Phe Ile Asp  Gly Asn Val 
    1385                 1390                 1395             


Glu Ser  Leu Met Thr Glu Leu  Glu Ile Glu Lys Ser  Leu Lys His 
    1400                 1405                 1410             


His Glu  Asp Ile Val Asp Glu  Ile Glu Cys Ile Glu  Lys Thr Leu 
    1415                 1420                 1425             


Leu Lys  Arg Arg Ser Glu Leu  Arg Glu Ala Asp Arg  Leu Leu Ala 
    1430                 1435                 1440             


Glu Ala  Glu Ser Glu Leu Ser  Cys Thr Lys Glu Lys  Thr Lys Asn 
    1445                 1450                 1455             


Ala Val  Glu Lys Phe Thr Asp  Ala Lys Arg Ser Leu  Leu Gln Thr 
    1460                 1465                 1470             


Glu Ser  Asp Ala Glu Glu Leu  Glu Arg Arg Ala Gln  Glu Thr Ala 
    1475                 1480                 1485             


Val Asn  Leu Val Lys Ala Asp  Gln Gln Leu Arg Ser  Leu Gln Ala 
    1490                 1495                 1500             


Asp Ala  Lys Asp Leu Glu Gln  His Lys Ile Lys Gln  Glu Glu Ile 
    1505                 1510                 1515             


Leu Lys  Glu Ile Asn Lys Ile  Val Ala Ala Lys Asp  Ser Asp Phe 
    1520                 1525                 1530             


Gln Cys  Leu Ser Lys Lys Lys  Glu Lys Leu Thr Glu  Glu Leu Gln 
    1535                 1540                 1545             


Lys Leu  Gln Lys Asp Ile Glu  Met Ala Glu Arg Asn  Glu Asp His 
    1550                 1555                 1560             


His Leu  Gln Val Leu Lys Glu  Ser Glu Val Leu Leu  Gln Ala Lys 
    1565                 1570                 1575             


Arg Ala  Glu Leu Glu Lys Leu  Lys Ser Gln Val Thr  Ser Gln Gln 
    1580                 1585                 1590             


Gln Glu  Met Ala Val Leu Asp  Arg Gln Leu Gly His  Lys Lys Glu 
    1595                 1600                 1605             


Glu Leu  His Leu Leu Gln Gly  Ser Met Val Gln Ala  Lys Ala Asp 
    1610                 1615                 1620             


Leu Gln  Glu Ala Leu Arg Leu  Gly Glu Thr Glu Val  Thr Glu Lys 
    1625                 1630                 1635             


Cys Asn  His Ile Arg Glu Val  Lys Ser Leu Leu Glu  Glu Leu Ser 
    1640                 1645                 1650             


Phe Gln  Lys Gly Glu Leu Asn  Val Gln Ile Ser Glu  Arg Lys Thr 
    1655                 1660                 1665             


Gln Leu  Thr Leu Ile Lys Gln  Glu Ile Glu Lys Glu  Glu Glu Asn 
    1670                 1675                 1680             


Leu Gln  Val Val Leu Arg Gln  Met Ser Lys His Lys  Thr Glu Leu 
    1685                 1690                 1695             


Lys Asn  Ile Leu Asp Met Leu  Gln Leu Glu Asn His  Glu Leu Gln 
    1700                 1705                 1710             


Gly Leu  Lys Leu Gln His Asp  Gln Arg Val Ser Glu  Leu Glu Lys 
    1715                 1720                 1725             


Thr Gln  Val Ala Val Leu Glu  Glu Lys Leu Glu Leu  Glu Asn Leu 
    1730                 1735                 1740             


Gln Gln  Ile Ser Gln Gln Gln  Lys Gly Glu Ile Glu  Trp Gln Lys 
    1745                 1750                 1755             


Gln Leu  Leu Glu Arg Asp Lys  Arg Glu Ile Glu Arg  Met Thr Ala 
    1760                 1765                 1770             


Glu Ser  Arg Ala Leu Gln Ser  Cys Val Glu Cys Leu  Ser Lys Glu 
    1775                 1780                 1785             


Lys Glu  Asp Leu Gln Glu Lys  Cys Asp Ile Trp Glu  Lys Lys Leu 
    1790                 1795                 1800             


Ala Gln  Thr Lys Arg Val Leu  Ala Ala Ala Glu Glu  Asn Ser Lys 
    1805                 1810                 1815             


Met Glu  Gln Ser Asn Leu Glu  Lys Leu Glu Leu Asn  Val Arg Lys 
    1820                 1825                 1830             


Leu Gln  Gln Glu Leu Asp Gln  Leu Asn Arg Asp Lys  Leu Ser Leu 
    1835                 1840                 1845             


His Asn  Asp Ile Ser Ala Met  Gln Gln Gln Leu Gln  Glu Lys Arg 
    1850                 1855                 1860             


Glu Ala  Val Asn Ser Leu Gln  Glu Glu Leu Ala Asn  Val Gln Asp 
    1865                 1870                 1875             


His Leu  Asn Leu Ala Lys Gln  Asp Leu Leu His Thr  Thr Lys His 
    1880                 1885                 1890             


Gln Asp  Val Leu Leu Ser Glu  Gln Thr Arg Leu Gln  Lys Asp Ile 
    1895                 1900                 1905             


Ser Glu  Trp Ala Asn Arg Phe  Glu Asp Cys Gln Lys  Glu Glu Glu 
    1910                 1915                 1920             


Thr Lys  Gln Gln Gln Leu Gln  Val Leu Gln Asn Glu  Ile Glu Glu 
    1925                 1930                 1935             


Asn Lys  Leu Lys Leu Val Gln  Gln Glu Met Met Phe  Gln Arg Leu 
    1940                 1945                 1950             


Gln Lys  Glu Arg Glu Ser Glu  Glu Ser Lys Leu Glu  Thr Ser Lys 
    1955                 1960                 1965             


Val Thr  Leu Lys Glu Gln Gln  His Gln Leu Glu Lys  Glu Leu Thr 
    1970                 1975                 1980             


Asp Gln  Lys Ser Lys Leu Asp  Gln Val Leu Ser Lys  Val Leu Ala 
    1985                 1990                 1995             


Ala Glu  Glu Arg Val Arg Thr  Leu Gln Glu Glu Glu  Arg Trp Cys 
    2000                 2005                 2010             


Glu Ser  Leu Glu Lys Thr Leu  Ser Gln Thr Lys Arg  Gln Leu Ser 
    2015                 2020                 2025             


Glu Arg  Glu Gln Gln Leu Val  Glu Lys Ser Gly Glu  Leu Leu Ala 
    2030                 2035                 2040             


Leu Gln  Lys Glu Ala Asp Ser  Met Arg Ala Asp Phe  Ser Leu Leu 
    2045                 2050                 2055             


Arg Asn  Gln Phe Leu Thr Glu  Arg Lys Lys Ala Glu  Lys Gln Val 
    2060                 2065                 2070             


Ala Ser  Leu Lys Glu Ala Leu  Lys Ile Gln Arg Ser  Gln Leu Glu 
    2075                 2080                 2085             


Lys Asn  Leu Leu Glu Gln Lys  Gln Glu Asn Ser Cys  Ile Gln Lys 
    2090                 2095                 2100             


Glu Met  Ala Thr Ile Glu Leu  Val Ala Gln Asp Asn  His Glu Arg 
    2105                 2110                 2115             


Ala Arg  Arg Leu Met Lys Glu  Leu Asn Gln Met Gln  Tyr Glu Tyr 
    2120                 2125                 2130             


Thr Glu  Leu Lys Lys Gln Met  Ala Asn Gln Lys Asp  Leu Glu Arg 
    2135                 2140                 2145             


Arg Gln  Met Glu Ile Ser Asp  Ala Met Arg Thr Leu  Lys Ser Glu 
    2150                 2155                 2160             


Val Lys  Asp Glu Ile Arg Thr  Ser Leu Lys Asn Leu  Asn Gln Phe 
    2165                 2170                 2175             


Leu Pro  Glu Leu Pro Ala Asp  Leu Glu Ala Ile Leu  Glu Arg Asn 
    2180                 2185                 2190             


Glu Asn  Leu Glu Gly Glu Leu  Glu Ser Leu Lys Glu  Asn Leu Pro 
    2195                 2200                 2205             


Phe Thr  Met Asn Glu Gly Pro  Phe Glu Glu Lys Leu  Asn Phe Ser 
    2210                 2215                 2220             


Gln Val  His Ile Met Asp Glu  His Trp Arg Gly Glu  Ala Leu Arg 
    2225                 2230                 2235             


Glu Lys  Leu Arg His Arg Glu  Asp Arg Leu Lys Ala  Gln Leu Arg 
    2240                 2245                 2250             


His Cys  Met Ser Lys Gln Ala  Glu Val Leu Ile Lys  Gly Lys Arg 
    2255                 2260                 2265             


Gln Thr  Glu Gly Thr Leu His  Ser Leu Arg Arg Gln  Val Asp Ala 
    2270                 2275                 2280             


Leu Gly  Glu Leu Val Thr Ser  Thr Ser Ala Asp Ser  Ala Ser Ser 
    2285                 2290                 2295             


Pro Ser  Leu Ser Gln Leu Glu  Ser Ser Leu Thr Glu  Asp Ser Gln 
    2300                 2305                 2310             


Leu Gly  Gln Asn Gln Lys Gln  Asn Asn Ser Leu Arg  
    2315                 2320                 2325 


<210> 8115
<211> 218
<212> PRT
<213> Homo sapiens

<400> 8115
Met Asp Glu Leu Val Thr Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile 
1               5                   10                  15      


Leu Leu Val Val Pro Lys Ala Thr Val Leu Gln Asn Gln Leu Asp Glu 
            20                  25                  30          


Ser Gln Gln Glu Arg Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu 
        35                  40                  45              


Gly Gln Val Thr Glu Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala 
    50                  55                  60                  


Leu Ala Thr Ala Arg Gln Glu His Thr Glu Leu Met Glu Gln Tyr Lys 
65                  70                  75                  80  


Gly Ile Ser Arg Ser His Gly Glu Ile Thr Glu Glu Arg Asp Ile Leu 
                85                  90                  95      


Ser Arg Gln Gln Gly Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp 
            100                 105                 110         


Asp Ile Gln Thr Ile Ser Glu Lys Val Leu Thr Lys Glu Val Glu Leu 
        115                 120                 125             


Asp Arg Leu Arg Asp Thr Val Lys Ala Leu Thr Arg Glu Gln Glu Lys 
    130                 135                 140                 


Leu Leu Gly Gln Leu Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu 
145                 150                 155                 160 


Ala Glu Leu Gln Val Ala Gln Gln Glu Asn His His Leu Asn Leu Asp 
                165                 170                 175     


Leu Lys Glu Ala Lys Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln 
            180                 185                 190         


Arg Leu Lys Asp Lys Val Ala Gln Met Lys Asp Thr Leu Gly Gln Ala 
        195                 200                 205             


Gln Gln Arg Val Arg Pro Ser Trp Ser Pro 
    210                 215             


<210> 8116
<211> 230
<212> PRT
<213> Homo sapiens

<400> 8116
Met Lys Lys Pro Arg Pro Ala Ala Ala Ala Pro Ser Pro Arg Pro Pro 
1               5                   10                  15      


Ala Cys Ser Arg Gly Ala His Pro Gly Thr Ala Ser Glu Leu Arg Val 
            20                  25                  30          


Pro Ala Leu Arg Arg Gly Gly Cys Gly Asp Arg Arg Leu Arg Glu Glu 
        35                  40                  45              


Ala Ala Pro Glu Gln Ala Ala Ala Gly Pro Arg Arg Ser Thr Val Gly 
    50                  55                  60                  


Ala Leu Leu Ala Ser Glu Leu Gly Trp Lys Phe Tyr Asp Ala Asp Asp 
65                  70                  75                  80  


Tyr His Pro Glu Glu Asn Arg Arg Lys Met Gly Lys Gly Ile Pro Leu 
                85                  90                  95      


Asn Asp Gln Asp Arg Ile Pro Trp Leu Cys Asn Leu His Asp Ile Leu 
            100                 105                 110         


Leu Arg Asp Val Ala Ser Gly Gln Arg Val Val Leu Ala Cys Ser Ala 
        115                 120                 125             


Leu Lys Lys Thr Tyr Arg Asp Ile Leu Thr Gln Gly Lys Asp Gly Val 
    130                 135                 140                 


Ala Leu Lys Cys Glu Glu Ser Gly Lys Glu Ala Lys Gln Ala Glu Met 
145                 150                 155                 160 


Gln Leu Leu Val Val His Leu Ser Gly Ser Phe Glu Val Ile Ser Gly 
                165                 170                 175     


Arg Leu Leu Lys Arg Glu Gly His Phe Met Pro Pro Glu Leu Leu Gln 
            180                 185                 190         


Ser Gln Phe Glu Thr Leu Glu Pro Pro Ala Ala Pro Glu Asn Phe Ile 
        195                 200                 205             


Gln Ile Ser Val Asp Lys Asn Val Ser Glu Ile Ile Ala Thr Ile Met 
    210                 215                 220                 


Glu Thr Leu Lys Met Lys 
225                 230 


<210> 8117
<211> 318
<212> PRT
<213> Homo sapiens

<400> 8117
Met Cys Arg Thr Ala Leu Gly Val Thr Thr Leu Gln Asp Leu Gly Val 
1               5                   10                  15      


Cys Trp Arg Lys Glu His Asp Pro Ala Glu Met Leu Arg Val Gly Arg 
            20                  25                  30          


Ala Glu Leu Gly Gly Trp Lys Pro Ser Trp Glu Ala Ile Val Lys Glu 
        35                  40                  45              


Val Ala Ala Ala Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu 
    50                  55                  60                  


Asp Ile Leu Ala Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys 
65                  70                  75                  80  


Val Ala Lys Lys Lys Phe Ala Glu Asn Leu Lys Ala Gly Asp Glu Phe 
                85                  90                  95      


Val Glu Lys Thr Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser 
            100                 105                 110         


Val Val His Ser Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu 
        115                 120                 125             


Lys Val Lys Asn Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu 
    130                 135                 140                 


His Thr Ile Phe Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile 
145                 150                 155                 160 


Ala Asn Ala Thr Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe 
                165                 170                 175     


Asn Pro Val Pro Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met 
            180                 185                 190         


Thr Ser Gln Lys Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu 
        195                 200                 205             


Gly Lys His Pro Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn 
    210                 215                 220                 


Arg Leu Leu Val Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg 
225                 230                 235                 240 


Gly Asp Ala Ser Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala 
                245                 250                 255     


Gly Tyr Pro Met Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp 
            260                 265                 270         


Thr Thr Lys Phe Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn 
        275                 280                 285             


Pro Leu His Gln Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn 
    290                 295                 300                 


Lys Phe Gly Lys Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys 
305                 310                 315             


<210> 8118
<211> 221
<212> PRT
<213> Homo sapiens

<400> 8118
Met Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser Val Ser Ser Leu 
            20                  25                  30          


Ile Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His 
        35                  40                  45              


Gly Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp Gly Leu Leu Arg 
    50                  55                  60                  


Gly Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala Val Pro Pro Arg 
65                  70                  75                  80  


Lys Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn Glu Asp Phe Arg 
                85                  90                  95      


Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu 
            100                 105                 110         


Gln Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu Ile 
        115                 120                 125             


Pro Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys Ile Leu Ile Arg 
    130                 135                 140                 


Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser 
145                 150                 155                 160 


Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gln 
                165                 170                 175     


Gly Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser Ser Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ala Ala Asp Lys Pro Leu Ala Phe Ser Gly Trp 
        195                 200                 205             


Ala Ser Gly Cys Pro Ser Gly Thr Leu Ser Asp Ser Gly 
    210                 215                 220     


<210> 8119
<211> 194
<212> PRT
<213> Homo sapiens

<400> 8119
Met Arg Glu Leu Ala Ala Val Val Ser Arg Asp Ile Tyr Leu His Asn 
1               5                   10                  15      


Pro Asn Ile Lys Trp Asn Asp Ile Ile Gly Leu Asp Ala Ala Lys Gln 
            20                  25                  30          


Leu Val Lys Glu Ala Val Val Tyr Pro Ile Arg Tyr Pro Gln Leu Phe 
        35                  40                  45              


Thr Gly Ile Leu Ser Pro Trp Lys Gly Leu Leu Leu Tyr Gly Pro Pro 
    50                  55                  60                  


Gly Thr Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Thr Glu Cys Lys 
65                  70                  75                  80  


Thr Thr Phe Phe Asn Ile Ser Ala Ser Thr Ile Val Ser Lys Trp Arg 
                85                  90                  95      


Gly Asp Ser Glu Lys Leu Val Arg Val Leu Phe Glu Leu Ala Arg Tyr 
            100                 105                 110         


His Ala Pro Ser Thr Ile Phe Leu Asp Glu Leu Glu Ser Val Met Ser 
        115                 120                 125             


Gln Arg Gly Thr Ala Ser Gly Gly Glu His Glu Gly Ser Leu Arg Met 
    130                 135                 140                 


Lys Thr Glu Leu Leu Val Gln Met Asp Gly Leu Ala Arg Ser Glu Asp 
145                 150                 155                 160 


Leu Val Phe Val Leu Ala Ala Ser Asn Leu Pro Cys Leu Lys Ala Ile 
                165                 170                 175     


Ala Leu Gln Pro Gly Asp Arg Ala Arg Leu Arg Leu Lys Lys Lys Lys 
            180                 185                 190         


Cys Thr 
        


<210> 8120
<211> 184
<212> PRT
<213> Homo sapiens

<400> 8120
Met Thr Phe Gln Phe Asn Phe Thr Ile Glu Asp His Leu Glu Asn Glu 
1               5                   10                  15      


Leu Thr Pro Ile Arg Asp Gly Ala Leu Thr Leu Asp Ser Ser Lys Glu 
            20                  25                  30          


Leu Ser Val Ser Glu Ser Gln Lys Gly Glu Glu Arg Asp Arg Lys Cys 
        35                  40                  45              


Ser Ala Glu Gln Phe Asp Leu Pro Gln Asp His Leu Trp Glu His Lys 
    50                  55                  60                  


Ser Met Glu Asn Ala Ala Pro Ser Gln Asp Thr Asp Ser Pro Leu Ser 
65                  70                  75                  80  


Ala Ala Ser Ser Ser Arg Asn Leu Glu Pro His Gly Lys Gln Pro Ser 
                85                  90                  95      


Leu Arg Ala Ala Lys Glu His Ala Met Pro Lys Asp Leu Lys Lys Met 
            100                 105                 110         


Leu Glu Asn Lys Val Ile Glu Thr Leu Pro Gly Phe Gln His Val Lys 
        115                 120                 125             


Leu Ser Val Val Lys Thr Ile Leu Leu Lys Glu Asn Phe Pro Gly Glu 
    130                 135                 140                 


Asn Ile Val Ser Lys Ser Phe Ser Ser His Ser Asp Leu Ile Thr Gly 
145                 150                 155                 160 


Val Tyr Glu Gly Gly Leu Lys Ile Trp Glu Cys Thr Phe Asp Leu Leu 
                165                 170                 175     


Ala Tyr Phe Thr Lys Ala Lys Val 
            180                 


<210> 8121
<211> 117
<212> PRT
<213> Homo sapiens

<400> 8121
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met 
        115         


<210> 8122
<211> 165
<212> PRT
<213> Homo sapiens

<400> 8122
Met Ile Leu Asn Val Leu Glu Tyr Gly Ser Gln Gln Val Ala Asp Leu 
1               5                   10                  15      


Thr Leu Asn Leu Asp Asp Tyr Ile Asp Ala Glu His Leu Gly Asp Phe 
            20                  25                  30          


His Arg Thr Tyr Lys Asn Ser Glu Glu Leu Arg Ser Arg Ile Val Ser 
        35                  40                  45              


Gly Ile Ile Thr Pro Ile His Glu Gln Trp Glu Lys Ala Asn Val Ser 
    50                  55                  60                  


Ser Pro His Arg Glu Phe Pro Pro Ala Thr Ala Arg Glu Val Asp Pro 
65                  70                  75                  80  


Leu Arg Ile Pro Pro His His Pro His Thr Ser Arg Gln Pro Pro Trp 
                85                  90                  95      


Pro Arg Arg Gly Gly Met Ile Val Asp Pro Leu Arg Ser Gly Phe Pro 
            100                 105                 110         


Arg Ala Leu Ile Asp Pro Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro 
        115                 120                 125             


Gly Ala Val Pro Pro Gly Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly 
    130                 135                 140                 


Thr Ser Pro Pro Gly Pro Asn Pro Asp His Leu Pro Pro Pro Gly Tyr 
145                 150                 155                 160 


Asp Asp Met Tyr Leu 
                165 


<210> 8123
<211> 122
<212> PRT
<213> Homo sapiens

<400> 8123
Ala Leu Thr Phe Ser Leu Arg Ala Gly Ala Ala Ser Ala Gln Asp Gly 
1               5                   10                  15      


Arg Cys Pro Cys Gly Ala Arg Arg Pro Asp Ser Arg Leu Leu Gln Leu 
            20                  25                  30          


His Ile Thr Met Pro Phe Ser Ser Pro Met Glu Ala Glu Leu Val Arg 
        35                  40                  45              


Arg Ile Leu Ser Arg Asp Ala Ala Pro Leu Pro Arg Pro Gly Ala Val 
    50                  55                  60                  


Leu Lys Asp Phe Thr Val Ser Gly Asn Leu Leu Phe Ile Arg Leu Thr 
65                  70                  75                  80  


Ala Ala Asp His Arg Gln Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln 
                85                  90                  95      


Gln Leu Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Phe 
            100                 105                 110         


Leu Ala Gln Ala Pro Ser Gly Gln Arg Arg 
        115                 120         


<210> 8124
<211> 804
<212> PRT
<213> Homo sapiens

<400> 8124
Met Lys Ser Ile Gly Val Lys Thr Val Lys Val Cys Gly Ser Lys Ser 
1               5                   10                  15      


Ser Val Arg Ile Glu Gly Gln Pro Cys Ser Leu Gly Gln Ser Arg Arg 
            20                  25                  30          


Lys Val Lys Leu Met Gly Glu Arg Ser Tyr Thr Leu Ser Ile Gly Asn 
        35                  40                  45              


Gly Asp Tyr Phe Trp Ala Asn Lys Glu Met Leu Trp Asp Tyr Val Gln 
    50                  55                  60                  


Thr Leu Ser Asp Gln Gly Ala Glu Lys His Glu Gly Thr Gly Gln Ser 
65                  70                  75                  80  


Ser Gly Ile Thr Asp Gln Glu Lys Glu Leu Ser Thr Asn Ala Phe Gln 
                85                  90                  95      


Ala Phe Thr Ser Gly Asn Tyr Asp Ala Cys Leu Gln His Leu Ala Cys 
            100                 105                 110         


Leu Gln Asp Ile Asn Lys Asp Asp Tyr Lys Ile Ile Leu Asn Thr Ala 
        115                 120                 125             


Val Ala Glu Phe Phe Lys Ser Asn Gln Thr Thr Thr Asp Asn Leu Arg 
    130                 135                 140                 


Gln Thr Leu Asn Gln Leu Lys Asn Gln Val His Ser Ala Val Glu Glu 
145                 150                 155                 160 


Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu Tyr Tyr Asn Gln 
                165                 170                 175     


Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Thr Glu Ala Ile Ser Val 
            180                 185                 190         


Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu Glu Lys Phe Ala 
        195                 200                 205             


Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile Leu Thr Tyr Gln 
    210                 215                 220                 


Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu Lys Met Ile Ser 
225                 230                 235                 240 


Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Thr Gly Asn Asn Asn 
                245                 250                 255     


Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly Ala Leu Ile Glu 
            260                 265                 270         


Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg Ala Tyr Ile Gln 
        275                 280                 285             


Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys Ser Val Met Asn 
    290                 295                 300                 


Thr Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys Ser Asn Phe Glu 
305                 310                 315                 320 


Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu Leu Asn Ser Ser 
                325                 330                 335     


Asn Ile Ala Glu His Pro Gly Phe Met Lys Thr Gly Glu Cys Leu Arg 
            340                 345                 350         


Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe Ala Met Ser Lys 
        355                 360                 365             


His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu Gln Glu Asn Asp 
    370                 375                 380                 


Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Thr Asp Pro Gly Lys Lys 
385                 390                 395                 400 


Phe Ser Gly Arg Pro Met Cys Thr Leu Leu Thr Asn Lys Arg Tyr Glu 
                405                 410                 415     


Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile Gly Arg Pro Leu 
            420                 425                 430         


Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val Tyr His Ala Asn 
        435                 440                 445             


Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile Ala Ala Asn Lys 
    450                 455                 460                 


Gly Thr Ser Glu Gln Glu Thr Lys Gly Leu Pro Ser Lys Lys Gly Ile 
465                 470                 475                 480 


Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys Ile Val Leu Ala 
                485                 490                 495     


Ser Gln Ser Ile Gln Asn Thr Val Tyr Asn Asp Gly Gln Ser Ser Ala 
            500                 505                 510         


Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys Leu Arg Asn Ala 
        515                 520                 525             


Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys Gln Glu Asn Gly 
    530                 535                 540                 


Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Thr Glu Ser Ser Glu Ser 
545                 550                 555                 560 


Ser Glu Thr Cys Ser Ser Lys Ser His Asp Gly Asp Lys Phe Ile Pro 
                565                 570                 575     


Ala Pro Pro Ser Ser Pro Leu Arg Lys Gln Glu Leu Glu Asn Leu Lys 
            580                 585                 590         


Cys Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu Ala Leu Gly Asp 
        595                 600                 605             


Asn Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu Gln Gln Pro Lys 
    610                 615                 620                 


Leu Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr Ala Ala Glu Ala 
625                 630                 635                 640 


Leu Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Thr His Leu Asn Pro 
                645                 650                 655     


Glu Asn Val Thr Asp Val Ser Leu Gly Ile Ser Ser Asn Glu Gln Asp 
            660                 665                 670         


Gln Gly Ser Asp Lys Gly Glu Asn Glu Ala Met Glu Ser Ser Gly Lys 
        675                 680                 685             


Arg Ala Pro Gln Cys Tyr Pro Ser Ser Val Asn Ser Ala Arg Thr Val 
    690                 695                 700                 


Met Leu Phe Asn Leu Gly Ser Ala Tyr Cys Leu Arg Ser Glu Tyr Asp 
705                 710                 715                 720 


Lys Ala Arg Lys Cys Leu His Gln Ala Ala Ser Met Ile His Pro Lys 
                725                 730                 735     


Glu Val Pro Pro Glu Ala Ile Leu Leu Ala Val Tyr Leu Glu Leu Gln 
            740                 745                 750         


Asn Gly Asn Thr Gln Leu Ala Leu Gln Ile Ile Lys Arg Asn Gln Leu 
        755                 760                 765             


Leu Pro Ala Val Lys Thr His Ser Glu Val Arg Lys Lys Pro Val Phe 
    770                 775                 780                 


Gln Pro Val His Pro Ile Gln Pro Ile Gln Met Pro Ala Phe Thr Thr 
785                 790                 795                 800 


Val Gln Arg Lys 
                


<210> 8125
<211> 632
<212> PRT
<213> Homo sapiens

<400> 8125
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                165                 170                 175     


Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
            180                 185                 190         


Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
        195                 200                 205             


Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
    210                 215                 220                 


Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
225                 230                 235                 240 


Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                245                 250                 255     


Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
            260                 265                 270         


Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
        275                 280                 285             


Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys Gly 
    290                 295                 300                 


Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys Arg 
305                 310                 315                 320 


Val Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys Ile 
                325                 330                 335     


Pro Thr Leu Ile Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu Ala 
            340                 345                 350         


Asp Phe Val Ser Gln Thr Ser Pro Met Ile Pro Ser Ile Val Val His 
        355                 360                 365             


Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Thr Gly Leu Tyr 
    370                 375                 380                 


Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys Phe 
385                 390                 395                 400 


Leu Arg Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile His 
                405                 410                 415     


Ala Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu Pro 
            420                 425                 430         


Leu Leu Thr Phe Arg Leu Asn Arg Ala Phe Met Glu Ala Ala Glu Ile 
        435                 440                 445             


Thr Asp Glu Asp Asn Ser Ile Ala Ala Met Tyr Gln Ala Val Gly Glu 
    450                 455                 460                 


Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His Leu 
465                 470                 475                 480 


Gln Arg Val Ala Gln Ser Pro His Thr Lys Met Asp Val Ala Asn Leu 
                485                 490                 495     


Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Ala Val Pro Asn Pro 
            500                 505                 510         


Asp Pro Val Thr Met Leu Gln Asp Ile Lys Arg Gln Pro Lys Val Val 
        515                 520                 525             


Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Ser Gln Phe Met Met 
    530                 535                 540                 


Val Glu Gln Glu Asn Ile Asp Pro Leu His Val Ile Glu Asn Ser Asn 
545                 550                 555                 560 


Ala Phe Ser Thr Pro Gln Thr Pro Asp Ile Lys Val Ser Leu Leu Gly 
                565                 570                 575     


Pro Val Thr Thr Pro Glu His Gln Leu Leu Lys Thr Pro Ser Ser Ser 
            580                 585                 590         


Ser Leu Ser Gln Arg Val Arg Ser Thr Leu Thr Lys Asn Thr Pro Arg 
        595                 600                 605             


Phe Gly Ser Lys Ser Lys Ser Ala Thr Asn Leu Gly Arg Gln Gly Asn 
    610                 615                 620                 


Phe Phe Ala Ser Pro Met Leu Lys 
625                 630         


<210> 8126
<211> 194
<212> PRT
<213> Homo sapiens

<400> 8126
Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn 
1               5                   10                  15      


Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu Pro Gln 
            20                  25                  30          


Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu Leu Ala 
        35                  40                  45              


Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe Glu Gln 
    50                  55                  60                  


Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val Glu Lys 
65                  70                  75                  80  


Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu Asp Pro 
                85                  90                  95      


Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu 
            100                 105                 110         


Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro 
        115                 120                 125             


Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr Phe Ala 
    130                 135                 140                 


Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr 
145                 150                 155                 160 


Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp 
                165                 170                 175     


Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys 
            180                 185                 190         


Lys Thr 
        


<210> 8127
<211> 600
<212> PRT
<213> Homo sapiens

<400> 8127
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met Glu Cys Phe Leu Gln Tyr Val Tyr Thr Gly Lys 
        115                 120                 125             


Val Lys Ile Thr Thr Glu Asn Val Gln Tyr Leu Phe Glu Thr Ser Ser 
    130                 135                 140                 


Leu Phe Gln Ile Ser Val Leu Arg Asp Ala Cys Ala Lys Phe Leu Glu 
145                 150                 155                 160 


Glu Gln Leu Asp Pro Cys Asn Cys Leu Gly Ile Gln Arg Phe Ala Asp 
                165                 170                 175     


Thr His Ser Leu Lys Thr Leu Phe Thr Lys Cys Lys Asn Phe Ala Leu 
            180                 185                 190         


Gln Thr Phe Glu Asp Val Ser Gln His Glu Glu Phe Leu Glu Leu Asp 
        195                 200                 205             


Lys Asp Glu Leu Ile Asp Tyr Ile Cys Ser Asp Glu Leu Val Ile Gly 
    210                 215                 220                 


Lys Glu Glu Met Val Phe Glu Ala Val Met Arg Trp Val Tyr Arg Ala 
225                 230                 235                 240 


Val Asp Leu Arg Arg Pro Leu Leu His Glu Leu Leu Thr His Val Arg 
                245                 250                 255     


Leu Pro Leu Leu His Pro Asn Tyr Phe Val Gln Thr Val Glu Val Asp 
            260                 265                 270         


Gln Leu Ile Gln Asn Ser Pro Glu Cys Tyr Gln Leu Leu His Glu Ala 
        275                 280                 285             


Arg Arg Tyr His Ile Leu Gly Asn Glu Met Met Ser Pro Arg Thr Arg 
    290                 295                 300                 


Pro Arg Arg Ser Thr Gly Tyr Ser Glu Val Ile Val Val Val Gly Gly 
305                 310                 315                 320 


Cys Glu Arg Val Gly Gly Phe Asn Leu Pro Tyr Thr Glu Cys Tyr Asp 
                325                 330                 335     


Pro Val Thr Gly Glu Trp Lys Ser Leu Ala Lys Leu Pro Glu Phe Thr 
            340                 345                 350         


Lys Ser Glu Tyr Ala Val Cys Ala Leu Arg Asn Asp Ile Leu Val Ser 
        355                 360                 365             


Gly Gly Arg Ile Asn Ser Arg Asp Val Trp Ile Tyr Asn Ser Gln Leu 
    370                 375                 380                 


Asn Ile Trp Ile Arg Val Ala Ser Leu Asn Lys Gly Arg Trp Arg His 
385                 390                 395                 400 


Lys Met Ala Val Leu Leu Gly Lys Val Tyr Val Val Gly Gly Tyr Asp 
                405                 410                 415     


Gly Gln Asn Arg Leu Ser Ser Val Glu Cys Tyr Asp Ser Phe Ser Asn 
            420                 425                 430         


Arg Trp Thr Glu Val Ala Pro Leu Lys Glu Ala Val Ser Ser Pro Ala 
        435                 440                 445             


Val Thr Ser Cys Val Gly Lys Leu Phe Val Ile Gly Gly Gly Pro Asp 
    450                 455                 460                 


Asp Asn Thr Cys Ser Asp Lys Val Gln Ser Tyr Asp Pro Glu Thr Asn 
465                 470                 475                 480 


Ser Trp Leu Leu Arg Ala Ala Ile Pro Ile Ala Lys Arg Cys Ile Thr 
                485                 490                 495     


Ala Val Ser Leu Asn Asn Leu Ile Tyr Val Ala Gly Gly Leu Thr Lys 
            500                 505                 510         


Ala Ile Tyr Cys Tyr Asp Pro Val Glu Asp Tyr Trp Met His Val Gln 
        515                 520                 525             


Asn Thr Phe Ser Arg Gln Glu Asn Cys Gly Met Ser Val Cys Asn Gly 
    530                 535                 540                 


Lys Ile Tyr Ile Leu Gly Gly Arg Arg Glu Asn Gly Glu Ala Thr Asp 
545                 550                 555                 560 


Thr Ile Leu Cys Tyr Asp Pro Ala Thr Ser Ile Ile Thr Gly Val Ala 
                565                 570                 575     


Ala Met Pro Arg Pro Val Ser Tyr His Gly Cys Val Thr Ile His Arg 
            580                 585                 590         


Tyr Asn Glu Lys Cys Phe Lys Leu 
        595                 600 


<210> 8128
<211> 539
<212> PRT
<213> Homo sapiens

<400> 8128
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 8129
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8129
Xaa Tyr Val Asn Ala Val Asp Ser Arg Trp Ser Ser Tyr Gly Asn Glu 
1               5                   10                  15      


Ala Thr Ser Ser Ala His Tyr Val Glu Arg Asp Arg Phe Ile Val Thr 
            20                  25                  30          


Asp Leu Ser Gly His Arg Lys His Ser Ser Thr Gly Asp Leu Leu Ser 
        35                  40                  45              


Leu Glu Leu Gln Gln Ala Lys Ser Asn Ser Leu Leu Leu Gln Arg Glu 
    50                  55                  60                  


Ala Asn Ala Leu Ala Met Gln Gln Lys Trp Asn Ser Leu Asp Glu Gly 
65                  70                  75                  80  


Arg His Leu Thr Leu Asn Leu Leu Ser Lys Glu Ile Glu Leu Arg Asn 
                85                  90                  95      


Gly Glu Leu Gln Ser Asp Tyr Thr Glu Asp Ala Thr Asp Thr Lys Pro 
            100                 105                 110         


Asp Arg Asp Ile Glu Leu Glu Leu Ser Ala Leu Asp Thr Asp Glu Pro 
        115                 120                 125             


Asp Gly Gln Ser Glu Pro Ile Glu Glu Ile Leu Asp Ile Gln Leu Gly 
    130                 135                 140                 


Ile Ser Ser Gln Asn Asp Gln Leu Leu Asn Gly Met Ala Val Glu Asn 
145                 150                 155                 160 


Gly His Pro Val Gln Gln His Gln Lys Glu Pro Pro Lys Gln Lys Lys 
                165                 170                 175     


Gln Ser Leu Gly Arg Ser Lys Lys Gln Phe Cys Arg 
            180                 185             


<210> 8130
<211> 601
<212> PRT
<213> Homo sapiens

<400> 8130
Met Glu Glu Thr Met Lys Leu Ala Thr Met Glu Asp Thr Val Glu Tyr 
1               5                   10                  15      


Cys Leu Phe Leu Ile Pro Asp Glu Ser Arg Asp Ser Asp Lys His Lys 
            20                  25                  30          


Glu Ile Leu Gln Lys Tyr Ile Glu Arg Ile Ile Thr Arg Phe Ala Pro 
        35                  40                  45              


Met Leu Val Pro Tyr Ile Trp Gln Asn Gln Pro Phe Asn Leu Lys Tyr 
    50                  55                  60                  


Lys Pro Gly Lys Gly Gly Val Pro Ala His Met Phe Gly Val Thr Lys 
65                  70                  75                  80  


Phe Gly Asp Asn Ile Glu Asp Glu Trp Phe Ile Val Tyr Val Ile Lys 
                85                  90                  95      


Gln Ile Thr Lys Glu Phe Pro Glu Leu Val Ala Arg Ile Glu Asp Asn 
            100                 105                 110         


Asp Gly Glu Phe Leu Leu Ile Glu Ala Ala Asp Phe Leu Pro Lys Trp 
        115                 120                 125             


Leu Asp Pro Glu Asn Ser Thr Asn Arg Val Phe Phe Cys His Gly Glu 
    130                 135                 140                 


Leu Cys Ile Ile Pro Ala Pro Arg Lys Ser Gly Ala Glu Ser Trp Leu 
145                 150                 155                 160 


Pro Thr Thr Pro Pro Thr Ile Pro Gln Ala Leu Asn Ile Ile Thr Ala 
                165                 170                 175     


His Ser Glu Lys Ile Leu Ala Ser Glu Ser Ile Arg Ala Ala Val Asn 
            180                 185                 190         


Arg Arg Ile Arg Gly Tyr Pro Glu Lys Ile Gln Ala Ser Leu His Arg 
        195                 200                 205             


Ala His Cys Phe Leu Pro Ala Gly Ile Val Ala Val Leu Lys Gln Arg 
    210                 215                 220                 


Pro Arg Leu Val Ala Ala Ala Val Gln Ala Phe Tyr Leu Arg Asp Pro 
225                 230                 235                 240 


Ile Asp Leu Arg Ala Cys Arg Val Phe Lys Thr Phe Leu Pro Glu Thr 
                245                 250                 255     


Arg Ile Met Thr Ser Ala His Gly Phe Glu Ile Leu Cys Ser Lys Cys 
            260                 265                 270         


Ser Pro His Phe Ser Asp Cys Lys Lys Ser Leu Val Thr Ala Ser Pro 
        275                 280                 285             


Leu Trp Ala Ser Phe Leu Glu Ser Leu Lys Lys Asn Asp Tyr Phe Lys 
    290                 295                 300                 


Gly Leu Ile Glu Gly Ser Ala Gln Tyr Arg Glu Arg Leu Glu Met Ala 
305                 310                 315                 320 


Glu Asn Tyr Phe Gln Leu Ser Val Asp Trp Pro Glu Ser Ser Leu Ala 
                325                 330                 335     


Met Ser Pro Gly Glu Glu Ile Leu Thr Leu Leu Gln Thr Ile Pro Phe 
            340                 345                 350         


Asp Ile Glu Asp Leu Lys Lys Glu Ala Ala Asn Leu Pro Pro Glu Asp 
        355                 360                 365             


Asp Asp Gln Trp Leu Asp Leu Ser Pro Asp Gln Leu Asp Gln Leu Leu 
    370                 375                 380                 


Gln Glu Ala Val Gly Lys Lys Glu Ser Glu Ser Val Ser Lys Glu Glu 
385                 390                 395                 400 


Lys Glu Gln Asn Tyr Asp Leu Thr Glu Val Ser Glu Ser Met Lys Ala 
                405                 410                 415     


Phe Ile Ser Lys Val Ser Thr His Lys Gly Ala Glu Leu Pro Arg Glu 
            420                 425                 430         


Pro Ser Glu Ala Pro Ile Thr Phe Asp Ala Asp Ser Phe Leu Asn Tyr 
        435                 440                 445             


Phe Asp Lys Ile Leu Gly Pro Arg Pro Asn Glu Ser Asp Ser Asp Asp 
    450                 455                 460                 


Leu Asp Asp Glu Asp Phe Glu Cys Leu Asp Ser Asp Asp Asp Leu Asp 
465                 470                 475                 480 


Phe Glu Thr His Glu Pro Gly Glu Glu Ala Ser Leu Lys Gly Thr Leu 
                485                 490                 495     


Asp Asn Leu Lys Ser Tyr Met Ala Gln Met Asp Gln Glu Leu Ala His 
            500                 505                 510         


Thr Cys Ile Ser Lys Ser Phe Thr Thr Arg Asn Gln Val Glu Pro Val 
        515                 520                 525             


Ser Gln Thr Thr Asp Asn Asn Ser Asp Glu Glu Asp Ser Gly Thr Gly 
    530                 535                 540                 


Glu Ser Val Met Ala Pro Val Asp Val Asp Leu Asn Leu Val Ser Asn 
545                 550                 555                 560 


Ile Leu Glu Ser Tyr Ser Ser Gln Ala Gly Leu Ala Gly Pro Ala Ser 
                565                 570                 575     


Asn Leu Leu Gln Ser Met Gly Val Gln Leu Pro Asp Asn Thr Asp His 
            580                 585                 590         


Arg Pro Thr Ser Lys Pro Thr Lys Asn 
        595                 600     


<210> 8131
<211> 134
<212> PRT
<213> Homo sapiens

<400> 8131
Met Lys Lys Lys His Asp Gly Ile Val Tyr Glu Thr Lys Glu Val Leu 
1               5                   10                  15      


Asn Pro Ser Pro Lys Val Thr His Cys Cys Lys Ser Leu Trp Leu Lys 
            20                  25                  30          


Tyr Ser Phe Gln Lys Ala Tyr Met Thr Gln Leu Val Ser Ser Gln Pro 
        35                  40                  45              


Val Pro Ala Met Ser Arg Asn Pro Asp His Asn Leu Leu Ser Gln Pro 
    50                  55                  60                  


Lys Glu His Ser Ile Val Gln Lys His His Gln Glu Glu Ile Ile His 
65                  70                  75                  80  


Lys Leu Ala Met Gln Leu Arg His Ile Gly Asp Asn Ile Asp His Arg 
                85                  90                  95      


Met Val Arg Glu Asp Leu Gln Gln Asp Gly Arg Asp Ala Leu Asp His 
            100                 105                 110         


Phe Val Phe Phe Phe Phe Arg Arg Val Gln Val Leu Leu His Phe Phe 
        115                 120                 125             


Trp Asn Asn His Leu Leu 
    130                 


<210> 8132
<211> 596
<212> PRT
<213> Homo sapiens

<400> 8132
Met Glu Asp Ala Pro Gln Arg Leu Arg Trp Gln Ala His Leu Glu Phe 
1               5                   10                  15      


Thr His Asn His Asp Val Gly Asp Leu Thr Trp Asp Lys Ile Ala Val 
            20                  25                  30          


Ser Leu Pro Arg Ser Glu Lys Leu Arg Ser Leu Val Leu Ala Gly Ile 
        35                  40                  45              


Pro His Gly Met Arg Pro Gln Leu Trp Met Arg Leu Ser Gly Ala Leu 
    50                  55                  60                  


Gln Lys Lys Arg Asn Ser Glu Leu Ser Tyr Arg Glu Ile Val Lys Asn 
65                  70                  75                  80  


Ser Ser Asn Asp Glu Thr Ile Ala Ala Lys Gln Ile Glu Lys Asp Leu 
                85                  90                  95      


Leu Arg Thr Met Pro Ser Asn Ala Cys Phe Ala Ser Met Gly Ser Ile 
            100                 105                 110         


Gly Val Pro Arg Leu Arg Arg Val Leu Arg Ala Leu Ala Trp Leu Tyr 
        115                 120                 125             


Pro Glu Ile Gly Tyr Cys Gln Gly Thr Gly Met Val Ala Ala Cys Leu 
    130                 135                 140                 


Leu Leu Phe Leu Glu Glu Glu Asp Ala Phe Trp Met Met Ser Ala Ile 
145                 150                 155                 160 


Ile Glu Asp Leu Leu Pro Ala Ser Tyr Phe Ser Thr Thr Leu Leu Gly 
                165                 170                 175     


Val Gln Thr Asp Gln Arg Val Leu Arg His Leu Ile Val Gln Tyr Leu 
            180                 185                 190         


Pro Arg Leu Asp Lys Leu Leu Gln Glu His Asp Ile Glu Leu Ser Leu 
        195                 200                 205             


Ile Thr Leu His Trp Phe Leu Thr Ala Phe Ala Ser Val Val Asp Ile 
    210                 215                 220                 


Lys Leu Leu Leu Arg Ile Trp Asp Leu Phe Phe Tyr Glu Gly Ser Arg 
225                 230                 235                 240 


Val Leu Phe Gln Leu Thr Leu Gly Met Leu His Leu Lys Glu Glu Glu 
                245                 250                 255     


Leu Ile Gln Ser Glu Asn Ser Ala Ser Ile Phe Asn Thr Leu Ser Asp 
            260                 265                 270         


Ile Pro Ser Gln Met Glu Asp Ala Glu Leu Leu Leu Gly Val Ala Met 
        275                 280                 285             


Arg Leu Ala Gly Ser Leu Thr Asp Val Ala Val Glu Thr Gln Arg Arg 
    290                 295                 300                 


Lys His Leu Ala Tyr Leu Ile Ala Asp Gln Gly Gln Leu Leu Gly Ala 
305                 310                 315                 320 


Gly Thr Leu Thr Asn Leu Ser Gln Val Val Arg Arg Arg Thr Gln Arg 
                325                 330                 335     


Arg Lys Ser Thr Ile Thr Ala Leu Leu Phe Gly Glu Asp Asp Leu Glu 
            340                 345                 350         


Ala Leu Lys Ala Lys Asn Ile Lys Gln Thr Glu Leu Val Ala Asp Leu 
        355                 360                 365             


Arg Glu Ala Ile Leu Arg Val Ala Arg His Phe Gln Cys Thr Asp Pro 
    370                 375                 380                 


Lys Asn Cys Ser Val Glu Leu Thr Pro Asp Tyr Ser Met Glu Ser His 
385                 390                 395                 400 


Gln Arg Asp His Glu Asn Tyr Val Ala Cys Ser Arg Ser His Arg Arg 
                405                 410                 415     


Arg Ala Lys Ala Leu Leu Asp Phe Glu Arg His Asp Asp Asp Glu Leu 
            420                 425                 430         


Gly Phe Arg Lys Asn Asp Ile Ile Thr Ile Val Ser Gln Lys Asp Glu 
        435                 440                 445             


His Cys Trp Val Gly Glu Leu Asn Gly Leu Arg Gly Trp Phe Pro Ala 
    450                 455                 460                 


Lys Phe Val Glu Val Leu Asp Glu Arg Ser Lys Glu Tyr Ser Ile Ala 
465                 470                 475                 480 


Gly Asp Asp Ser Val Thr Glu Gly Val Thr Asp Leu Val Arg Gly Thr 
                485                 490                 495     


Leu Cys Pro Ala Leu Lys Ala Leu Phe Glu His Gly Leu Lys Lys Pro 
            500                 505                 510         


Ser Leu Leu Gly Gly Ala Cys His Pro Trp Leu Phe Ile Glu Glu Ala 
        515                 520                 525             


Ala Gly Arg Glu Val Glu Arg Asp Phe Ala Ser Val Tyr Ser Arg Leu 
    530                 535                 540                 


Val Leu Cys Lys Thr Phe Arg Leu Asp Glu Asp Gly Lys Val Leu Thr 
545                 550                 555                 560 


Pro Glu Glu Leu Leu Tyr Arg Ala Val Gln Ser Val Asn Val Thr His 
                565                 570                 575     


Asp Ala Val His Ala Gln Met Asp Val Lys Leu Arg Ser Leu Ile Cys 
            580                 585                 590         


Val Gly Leu Lys 
        595     


<210> 8133
<211> 132
<212> PRT
<213> Homo sapiens

<400> 8133
Met Glu Ser Arg Val Ala Asp Ala Gly Thr Gly Glu Thr Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Thr Thr Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Thr Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Thr Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Thr Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Thr Ser Phe Asp Asn Thr Gly Asn Val Trp Ser Phe 
        115                 120                 125             


Ser Arg Gly Lys 
    130         


<210> 8134
<211> 539
<212> PRT
<213> Homo sapiens

<400> 8134
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 8135
<211> 730
<212> PRT
<213> Homo sapiens

<400> 8135
Met Asn Asn Ser Ser Ser Glu Thr Arg Gly His Pro His Ser Ala Ser 
1               5                   10                  15      


Ser Pro Ser Glu Arg Val Phe Pro Met Pro Leu Pro Arg Lys Ala Pro 
            20                  25                  30          


Leu Asn Ile Pro Gly Thr Pro Val Leu Glu Asp Phe Pro Gln Asn Asp 
        35                  40                  45              


Asp Glu Lys Glu Arg Leu Gln Arg Arg Arg Ser Arg Val Phe Asp Leu 
    50                  55                  60                  


Gln Phe Ser Thr Asp Ser Pro Arg Leu Leu Ala Ser Pro Ser Ser Arg 
65                  70                  75                  80  


Ser Ile Asp Ile Ser Ala Thr Ile Pro Lys Phe Thr Asn Thr Gln Ile 
                85                  90                  95      


Thr Glu His Tyr Ser Thr Cys Ile Lys Leu Ser Thr Glu Asn Lys Ile 
            100                 105                 110         


Thr Thr Lys Asn Ala Phe Gly Leu His Leu Ile Asp Phe Met Ser Glu 
        115                 120                 125             


Ile Leu Lys Gln Lys Asp Thr Glu Pro Thr Asn Phe Lys Val Ala Ala 
    130                 135                 140                 


Gly Thr Leu Asp Ala Ser Thr Lys Ile Tyr Ala Val Arg Val Asp Ala 
145                 150                 155                 160 


Val His Ala Asp Val Tyr Arg Val Leu Gly Gly Leu Gly Lys Asp Ala 
                165                 170                 175     


Pro Ser Leu Glu Glu Val Glu Gly His Val Ala Asp Gly Ser Ala Thr 
            180                 185                 190         


Glu Met Gly Thr Thr Lys Lys Ala Val Lys Pro Lys Lys Lys His Leu 
        195                 200                 205             


His Arg Thr Ile Glu Gln Asn Ile Asn Asn Leu Asn Val Ser Glu Ala 
    210                 215                 220                 


Asp Arg Lys Cys Glu Ile Asp Pro Met Phe Gln Lys Thr Ala Ala Ser 
225                 230                 235                 240 


Phe Asp Glu Cys Ser Thr Ala Gly Val Phe Leu Ser Thr Leu His Cys 
                245                 250                 255     


Gln Asp Tyr Arg Ser Glu Leu Leu Phe Pro Ser Asp Val Gln Thr Leu 
            260                 265                 270         


Ser Thr Gly Glu Pro Leu Glu Leu Pro Glu Leu Gly Cys Val Glu Met 
        275                 280                 285             


Thr Asp Leu Lys Ala Pro Leu Gln Gln Cys Ala Glu Asp Arg Gln Ile 
    290                 295                 300                 


Cys Pro Ser Leu Ala Gly Phe Gln Phe Thr Gln Trp Asp Ser Glu Thr 
305                 310                 315                 320 


His Asn Glu Ser Val Ser Ala Leu Val Asp Lys Phe Lys Lys Asn Asp 
                325                 330                 335     


Gln Val Phe Asp Ile Asn Ala Glu Val Asp Glu Ser Asp Cys Gly Asp 
            340                 345                 350         


Phe Pro Asp Gly Ser Leu Gly Asp Asp Phe Asp Ala Asn Asp Glu Pro 
        355                 360                 365             


Asp His Thr Ala Val Gly Asp His Glu Glu Phe Arg Ser Trp Lys Glu 
    370                 375                 380                 


Pro Cys Gln Val Gln Ser Cys Gln Glu Glu Met Ile Ser Leu Gly Asp 
385                 390                 395                 400 


Gly Asp Ile Arg Thr Met Cys Pro Leu Leu Ser Met Lys Pro Gly Glu 
                405                 410                 415     


Tyr Ser Tyr Phe Ser Pro Arg Thr Met Ser Met Trp Ala Gly Pro Asp 
            420                 425                 430         


His Trp Arg Phe Arg Pro Arg Arg Lys Gln Asp Ala Pro Ser Gln Ser 
        435                 440                 445             


Glu Asn Lys Lys Lys Ser Thr Lys Lys Asp Phe Glu Ile Asp Phe Glu 
    450                 455                 460                 


Asp Asp Ile Asp Phe Asp Val Tyr Phe Arg Lys Thr Lys Ala Ala Thr 
465                 470                 475                 480 


Ile Leu Thr Lys Ser Thr Leu Glu Asn Gln Asn Trp Arg Ala Thr Thr 
                485                 490                 495     


Leu Pro Thr Asp Phe Asn Tyr Asn Val Asp Thr Leu Val Gln Leu His 
            500                 505                 510         


Leu Lys Pro Gly Thr Arg Leu Leu Lys Met Ala Gln Gly His Arg Val 
        515                 520                 525             


Glu Thr Glu His Tyr Glu Glu Ile Glu Asp Tyr Asp Tyr Asn Asn Pro 
    530                 535                 540                 


Asn Asp Thr Ser Asn Phe Cys Pro Gly Leu Gln Ala Ala Asp Ser Asp 
545                 550                 555                 560 


Asp Glu Asp Leu Asp Asp Leu Phe Val Gly Pro Val Gly Asn Ser Asp 
                565                 570                 575     


Leu Ser Pro Tyr Pro Cys His Pro Pro Lys Thr Ala Gln Gln Asn Gly 
            580                 585                 590         


Asp Thr Pro Glu Ala Gln Gly Leu Asp Ile Thr Thr Tyr Gly Glu Ser 
        595                 600                 605             


Asn Leu Val Ala Glu Pro Gln Lys Val Asn Lys Ile Glu Ile His Tyr 
    610                 615                 620                 


Ala Lys Thr Ala Lys Lys Met Asp Met Lys Lys Leu Lys Gln Ser Met 
625                 630                 635                 640 


Trp Ser Leu Leu Thr Ala Leu Ser Gly Lys Glu Ala Asp Ala Glu Ala 
                645                 650                 655     


Asn His Arg Glu Ala Gly Lys Glu Ala Ala Leu Ala Glu Val Ala Asp 
            660                 665                 670         


Glu Lys Met Leu Ser Gly Leu Thr Lys Asp Leu Gln Arg Ser Leu Pro 
        675                 680                 685             


Pro Val Met Ala Gln Asn Leu Ser Ile Pro Leu Ala Phe Ala Cys Leu 
    690                 695                 700                 


Leu His Leu Ala Asn Glu Lys Asn Leu Lys Leu Glu Gly Thr Glu Asp 
705                 710                 715                 720 


Leu Ser Asp Val Leu Val Arg Gln Gly Asp 
                725                 730 


<210> 8136
<211> 299
<212> PRT
<213> Homo sapiens

<400> 8136
Met Glu Thr Gln Phe Pro Val Ser Glu Gly Lys Val Asp Pro Tyr Arg 
1               5                   10                  15      


Ser Cys Gly Phe Ser Tyr Glu Gln Asp Pro Thr Leu Arg Asp Pro Glu 
            20                  25                  30          


Ala Val Ala Arg Arg Trp Pro Trp Met Val Ser Val Arg Ala Asn Gly 
        35                  40                  45              


Thr His Ile Cys Ala Gly Thr Ile Ile Ala Ser Gln Trp Val Leu Thr 
    50                  55                  60                  


Val Ala His Cys Leu Ile Trp Arg Asp Val Ile Tyr Ser Val Arg Val 
65                  70                  75                  80  


Gly Ser Pro Trp Ile Asp Gln Met Thr Gln Thr Ala Ser Asp Val Pro 
                85                  90                  95      


Val Leu Gln Val Ile Met His Ser Arg Tyr Arg Ala Gln Arg Phe Trp 
            100                 105                 110         


Ser Trp Val Gly Gln Ala Asn Asp Ile Gly Leu Leu Lys Leu Lys Gln 
        115                 120                 125             


Glu Leu Lys Tyr Ser Asn Tyr Val Arg Pro Ile Cys Leu Pro Gly Thr 
    130                 135                 140                 


Asp Tyr Val Leu Lys Asp His Ser Arg Cys Thr Val Thr Gly Trp Gly 
145                 150                 155                 160 


Leu Ser Lys Ala Asp Gly Met Trp Pro Gln Phe Arg Thr Ile Gln Glu 
                165                 170                 175     


Lys Glu Val Ile Ile Leu Asn Asn Lys Glu Cys Asp Asn Phe Tyr His 
            180                 185                 190         


Asn Phe Thr Lys Ile Pro Thr Leu Val Gln Ile Ile Lys Ser Gln Met 
        195                 200                 205             


Met Cys Ala Glu Asp Thr His Arg Glu Lys Phe Cys Tyr Glu Leu Thr 
    210                 215                 220                 


Gly Glu Pro Leu Val Cys Ser Met Glu Gly Thr Trp Tyr Leu Val Gly 
225                 230                 235                 240 


Leu Val Ser Trp Gly Ala Gly Cys Gln Lys Ser Glu Ala Pro Pro Ile 
                245                 250                 255     


Tyr Leu Gln Val Ser Ser Tyr Gln His Trp Ile Trp Asp Cys Leu Asn 
            260                 265                 270         


Gly Gln Ala Leu Ala Leu Pro Ala Pro Ser Arg Thr Leu Leu Leu Ala 
        275                 280                 285             


Leu Pro Leu Pro Leu Ser Leu Leu Ala Ala Leu 
    290                 295                 


<210> 8137
<211> 362
<212> PRT
<213> Homo sapiens

<400> 8137
Met Leu Val Pro Gly Ser Thr Arg Pro Tyr Ser Lys Lys Arg Gln Asn 
1               5                   10                  15      


Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr 
            20                  25                  30          


Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu 
        35                  40                  45              


Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly 
    50                  55                  60                  


Ser Asn Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln 
65                  70                  75                  80  


Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe 
                85                  90                  95      


Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln 
            100                 105                 110         


Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn 
        115                 120                 125             


Glu Val Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu 
    130                 135                 140                 


Asp His Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr 
145                 150                 155                 160 


Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu 
                165                 170                 175     


Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe 
            180                 185                 190         


Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro 
        195                 200                 205             


Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val 
    210                 215                 220                 


Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys 
225                 230                 235                 240 


Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val 
                245                 250                 255     


Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu 
            260                 265                 270         


Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe 
        275                 280                 285             


Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser 
    290                 295                 300                 


Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg 
305                 310                 315                 320 


Ser Pro Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr 
                325                 330                 335     


Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe 
            340                 345                 350         


Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
        355                 360         


<210> 8138
<211> 599
<212> PRT
<213> Homo sapiens

<400> 8138
Met Asp Pro Gly Asp Ala Ala Ile Leu Glu Ser Ser Leu Arg Ile Leu 
1               5                   10                  15      


Tyr Arg Leu Phe Glu Ser Val Leu Pro Pro Leu Pro Ala Ala Leu Gln 
            20                  25                  30          


Ser Arg Met Asn Val Ile Asp His Val Arg Asp Met Ala Ala Ala Gly 
        35                  40                  45              


Leu His Ser Asn Val Arg Leu Leu Ser Ser Leu Leu Leu Thr Met Ser 
    50                  55                  60                  


Asn Asn Asn Pro Glu Leu Phe Ser Pro Pro Gln Lys Tyr Gln Leu Leu 
65                  70                  75                  80  


Val Tyr His Ala Asp Ser Leu Phe His Asp Lys Glu Tyr Arg Asn Ala 
                85                  90                  95      


Val Ser Lys Tyr Thr Met Ala Leu Gln Gln Lys Lys Ala Leu Ser Lys 
            100                 105                 110         


Thr Ser Lys Val Arg Pro Ser Thr Gly Asn Ser Ala Ser Thr Pro Gln 
        115                 120                 125             


Ser Gln Cys Leu Pro Ser Glu Ile Glu Val Lys Tyr Lys Met Ala Glu 
    130                 135                 140                 


Cys Tyr Thr Met Leu Lys Gln Asp Lys Asp Ala Ile Ala Ile Leu Asp 
145                 150                 155                 160 


Gly Ile Pro Ser Arg Gln Arg Thr Pro Lys Ile Asn Met Met Leu Ala 
                165                 170                 175     


Asn Leu Tyr Lys Lys Ala Gly Gln Glu Arg Pro Ser Val Thr Ser Tyr 
            180                 185                 190         


Lys Glu Val Leu Arg Gln Cys Pro Leu Ala Leu Asp Ala Ile Leu Gly 
        195                 200                 205             


Leu Leu Ser Leu Ser Val Lys Gly Ala Glu Val Ala Ser Met Thr Met 
    210                 215                 220                 


Asn Val Ile Gln Thr Val Pro Asn Leu Asp Trp Leu Ser Val Trp Ile 
225                 230                 235                 240 


Lys Ala Tyr Ala Phe Val His Thr Gly Asp Asn Ser Arg Ala Ile Ser 
                245                 250                 255     


Thr Ile Cys Ser Leu Glu Lys Lys Ser Leu Leu Arg Asp Asn Val Asp 
            260                 265                 270         


Leu Leu Gly Ser Leu Ala Asp Leu Tyr Phe Arg Ala Gly Asp Asn Lys 
        275                 280                 285             


Asn Ser Val Leu Lys Phe Glu Gln Ala Gln Met Leu Asp Pro Tyr Leu 
    290                 295                 300                 


Ile Lys Gly Met Asp Val Tyr Gly Tyr Leu Leu Ala Arg Glu Gly Arg 
305                 310                 315                 320 


Leu Glu Asp Val Glu Asn Leu Gly Cys Arg Leu Phe Asn Ile Ser Asp 
                325                 330                 335     


Gln His Ala Glu Pro Trp Val Val Ser Gly Cys His Ser Phe Tyr Ser 
            340                 345                 350         


Lys Arg Tyr Ser Arg Ala Leu Tyr Leu Gly Ala Lys Ala Ile Gln Leu 
        355                 360                 365             


Asn Ser Asn Ser Val Gln Ala Leu Leu Leu Lys Gly Ala Ala Leu Arg 
    370                 375                 380                 


Asn Met Gly Arg Val Gln Glu Ala Ile Ile His Phe Arg Glu Ala Ile 
385                 390                 395                 400 


Arg Leu Ala Pro Cys Arg Leu Asp Cys Tyr Glu Gly Leu Ile Glu Cys 
                405                 410                 415     


Tyr Leu Ala Ser Asn Ser Ile Arg Glu Ala Met Val Met Ala Asn Asn 
            420                 425                 430         


Val Tyr Lys Thr Leu Gly Ala Asn Ala Gln Thr Leu Thr Leu Leu Ala 
        435                 440                 445             


Thr Val Cys Leu Glu Asp Pro Val Thr Gln Glu Lys Ala Lys Thr Leu 
    450                 455                 460                 


Leu Asp Lys Ala Leu Thr Gln Arg Pro Asp Tyr Ile Lys Ala Val Val 
465                 470                 475                 480 


Lys Lys Ala Glu Leu Leu Ser Arg Glu Gln Lys Tyr Glu Asp Gly Ile 
                485                 490                 495     


Ala Leu Leu Arg Asn Ala Leu Ala Asn Gln Ser Asp Cys Val Leu His 
            500                 505                 510         


Arg Ile Leu Gly Asp Phe Leu Val Ala Val Asn Glu Tyr Gln Glu Ala 
        515                 520                 525             


Met Asp Gln Tyr Ser Ile Ala Leu Ser Leu Asp Pro Asn Asp Gln Lys 
    530                 535                 540                 


Ser Leu Glu Gly Met Gln Lys Met Glu Lys Glu Glu Ser Pro Thr Asp 
545                 550                 555                 560 


Ala Thr Gln Glu Glu Asp Val Asp Asp Met Glu Gly Ser Gly Glu Glu 
                565                 570                 575     


Gly Asp Leu Glu Gly Ser Asp Ser Glu Ala Ala Gln Trp Ala Asp Gln 
            580                 585                 590         


Glu Gln Trp Phe Gly Met Gln 
        595                 


<210> 8139
<211> 168
<212> PRT
<213> Homo sapiens

<400> 8139
Met Pro Ala Thr Arg Lys Pro Met Arg Tyr Gly His Thr Glu Gly His 
1               5                   10                  15      


Thr Glu Val Cys Phe Asp Asp Ser Gly Ser Phe Ile Val Thr Cys Gly 
            20                  25                  30          


Ser Asp Gly Asp Val Arg Ile Trp Glu Asp Leu Asp Asp Asp Asp Pro 
        35                  40                  45              


Lys Phe Ile Asn Val Gly Glu Lys Ala Tyr Ser Cys Ala Leu Lys Ser 
    50                  55                  60                  


Gly Lys Leu Val Thr Ala Val Ser Asn Asn Thr Ile Gln Val His Thr 
65                  70                  75                  80  


Phe Pro Glu Gly Val Pro Asp Gly Ile Leu Thr Arg Phe Thr Thr Asn 
                85                  90                  95      


Ala Asn His Val Val Phe Asn Gly Asp Gly Thr Lys Ile Ala Ala Gly 
            100                 105                 110         


Ser Ser Asp Phe Leu Val Lys Ile Val Asp Val Met Asp Ser Ser Gln 
        115                 120                 125             


Gln Lys Thr Phe Arg Gly His Asp Ala Pro Val Leu Ser Leu Ser Phe 
    130                 135                 140                 


Asp Pro Lys Asp Ile Phe Leu Ala Ser Ala Ser Cys Asp Gly Ser Val 
145                 150                 155                 160 


Arg Val Trp Gln Ile Ser Asp Gln 
                165             


<210> 8140
<211> 46
<212> PRT
<213> Homo sapiens

<400> 8140
Met Val Asn Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly 
1               5                   10                  15      


Leu Glu Asn Cys Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg 
            20                  25                  30          


Thr Thr Cys Cys Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys 
        35                  40                  45      


<210> 8141
<211> 222
<212> PRT
<213> Homo sapiens

<400> 8141
Met Ala Ser Val Val Glu Tyr Lys Gly Leu Arg Ala Gly Tyr His Cys 
1               5                   10                  15      


Gly Tyr Cys Asp Ser Lys Glu Gly Lys Ala Ser Cys Gly Met Trp Ala 
            20                  25                  30          


His Ser Met Thr Val Gln Asp Tyr Gln Asp Leu Ile Asp Arg Gly Trp 
        35                  40                  45              


Arg Arg Ser Gly Lys Tyr Val Tyr Lys Pro Val Met Asn Gln Thr Cys 
    50                  55                  60                  


Cys Pro Gln Tyr Thr Ile Arg Cys Arg Pro Leu Gln Phe Gln Pro Ser 
65                  70                  75                  80  


Lys Ser His Lys Lys Val Leu Lys Lys Met Leu Lys Phe Leu Ala Lys 
                85                  90                  95      


Gly Glu Val Pro Lys Gly Ser Cys Glu Asp Glu Pro Met Asp Ser Thr 
            100                 105                 110         


Met Asp Asp Ala Val Ala Gly Asp Phe Ala Leu Ile Asn Lys Leu Asp 
        115                 120                 125             


Ile Gln Cys Asp Leu Lys Thr Leu Ser Asp Asp Ile Lys Glu Ser Leu 
    130                 135                 140                 


Glu Ser Glu Gly Lys Asn Ser Lys Lys Glu Glu Pro Gln Glu Leu Leu 
145                 150                 155                 160 


Gln Ser Gln Asp Phe Val Gly Glu Lys Leu Gly Ser Gly Glu Pro Ser 
                165                 170                 175     


His Ser Val Lys Val His Thr Val Pro Lys Pro Gly Lys Gly Ala Asp 
            180                 185                 190         


Leu Ser Lys Pro Pro Cys Arg Lys Ala Lys Glu Ile Arg Lys Glu Arg 
        195                 200                 205             


Lys Arg Leu Lys Leu Met Gln Gln Asn Pro Ala Gly Glu Leu 
    210                 215                 220         


<210> 8142
<211> 164
<212> PRT
<213> Homo sapiens

<400> 8142
Met Leu Lys Ala Val Ile Leu Ile Gly Gly Pro Gln Lys Gly Thr Arg 
1               5                   10                  15      


Phe Arg Pro Leu Ser Phe Glu Val Pro Lys Pro Leu Phe Pro Val Ala 
            20                  25                  30          


Gly Val Pro Met Ile Gln His His Ile Glu Ala Cys Ala Gln Val Pro 
        35                  40                  45              


Gly Met Gln Glu Ile Leu Leu Ile Gly Phe Tyr Gln Pro Asp Glu Pro 
    50                  55                  60                  


Leu Thr Gln Phe Leu Glu Ala Ala Gln Gln Glu Phe Asn Leu Pro Val 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Phe Ala Pro Leu Gly Thr Gly Gly Gly Leu Tyr 
                85                  90                  95      


His Phe Arg Asp Gln Ile Leu Ala Gly Ser Pro Glu Ala Phe Phe Val 
            100                 105                 110         


Leu Asn Ala Asp Val Cys Ser Asp Phe Pro Leu Ser Ala Met Leu Glu 
        115                 120                 125             


Ala His Arg Arg Gln Arg His Pro Phe Leu Leu Leu Gly Thr Thr Ala 
    130                 135                 140                 


Asn Arg Thr Gln Ser Leu Asn Tyr Gly Cys Ile Val Glu Asn Pro Gln 
145                 150                 155                 160 


Thr His Glu Val 
                


<210> 8143
<211> 112
<212> PRT
<213> Homo sapiens

<400> 8143
Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


<210> 8144
<211> 313
<212> PRT
<213> Homo sapiens

<400> 8144
Thr Leu Val Val Ser Gly Arg Asp Asp Pro Pro Thr His Ser Gln Pro 
1               5                   10                  15      


Asp Ser Asp Asp Glu Ala Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn 
            20                  25                  30          


Thr Ala Thr Leu Thr Ala Pro Glu Phe Pro Glu Phe Ala Thr Lys Val 
        35                  40                  45              


Gln Glu Ala Ile Asn Ser Leu Gly Gly Ser Val Phe Pro Lys Leu Asn 
    50                  55                  60                  


Trp Ser Ala Pro Arg Asp Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu 
65                  70                  75                  80  


Lys Cys Lys Thr Leu Ser Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp 
                85                  90                  95      


Phe Ile Thr Arg Asp Phe Thr Gln Pro Phe Ile His Cys Thr Asp Asp 
            100                 105                 110         


Ser Pro Asp Pro Cys Ile Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys 
        115                 120                 125             


Glu Leu Ile Pro Gly Ala Glu Phe Arg Cys Phe Val Lys Glu Asn Lys 
    130                 135                 140                 


Leu Ile Gly Ile Ser Gln Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile 
145                 150                 155                 160 


Ser Lys Gln Lys Glu Glu Ile Arg Arg Cys Ile Gln Asp Phe Phe Lys 
                165                 170                 175     


Lys His Ile Gln Tyr Lys Phe Leu Asp Glu Asp Phe Val Phe Asp Ile 
            180                 185                 190         


Tyr Arg Asp Ser Arg Asp Ser Pro Ala Phe Arg Cys Thr Asn Ser Glu 
        195                 200                 205             


Val Thr Val Gln Pro Ser Pro Tyr Leu Ser Tyr Arg Leu Pro Lys Asp 
    210                 215                 220                 


Phe Val Asp Leu Ser Thr Gly Glu Asp Ala His Lys Leu Ile Asp Lys 
225                 230                 235                 240 


Ser Ala Gly Gly Arg Leu Met Ser Val Leu Glu Leu Glu Lys Arg Arg 
                245                 250                 255     


Pro Arg Pro Thr Ala Pro Gly Ala Ala His Gln Pro Gln Leu Pro Ala 
            260                 265                 270         


Asp Pro Asp Ala Gly Gly Pro Ser Ser Val Asp Ile Ser His Phe Leu 
        275                 280                 285             


Tyr Ser Cys Thr Phe Thr Trp Gly Lys Lys Arg Arg Asp Phe Ala Thr 
    290                 295                 300                 


Cys Lys Asn Asn Ile Ile Asn Arg Ser 
305                 310             


<210> 8145
<211> 338
<212> PRT
<213> Homo sapiens

<400> 8145
Met Glu Leu Trp Gly Arg Met Leu Trp Ala Leu Leu Ser Gly Pro Gly 
1               5                   10                  15      


Arg Arg Gly Ser Thr Arg Gly Trp Ala Phe Ser Ser Trp Gln Pro Gln 
            20                  25                  30          


Pro Pro Leu Ala Gly Leu Ser Ser Ala Ile Glu Leu Val Ser His Trp 
        35                  40                  45              


Thr Gly Val Phe Glu Lys Arg Gly Ile Pro Glu Ala Arg Glu Ser Ser 
    50                  55                  60                  


Glu Tyr Ile Val Ala His Val Leu Gly Ala Lys Thr Phe Gln Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Leu Trp Thr Gln Pro Leu Thr Ser Gln Gln Leu Gln Cys 
                85                  90                  95      


Ile Arg Glu Leu Ser Ser Arg Arg Leu Gln Arg Met Pro Val Gln Tyr 
            100                 105                 110         


Ile Leu Gly Glu Trp Asp Phe Gln Gly Leu Ser Leu Arg Met Val Pro 
        115                 120                 125             


Pro Val Phe Ile Pro Arg Pro Glu Thr Glu Glu Leu Val Glu Trp Val 
    130                 135                 140                 


Leu Glu Glu Val Ala Gln Arg Ser His Ala Val Gly Ser Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Ile Leu Glu Val Gly Cys Gly Ser Gly Ala Ile Ser Leu Ser 
                165                 170                 175     


Leu Leu Ser Gln Leu Pro Gln Ser Arg Val Ile Ala Val Asp Lys Arg 
            180                 185                 190         


Glu Ala Ala Ile Ser Leu Thr His Glu Asn Ala Gln Arg Leu Arg Leu 
        195                 200                 205             


Gln Asp Arg Ile Trp Ile Ile His Leu Asp Met Thr Ser Glu Arg Ser 
    210                 215                 220                 


Trp Thr His Leu Pro Trp Gly Pro Met Asp Leu Ile Val Ser Asn Pro 
225                 230                 235                 240 


Pro Tyr Val Phe His Gln Asp Met Glu Gln Leu Ala Pro Glu Ile Arg 
                245                 250                 255     


Ser Tyr Glu Asp Pro Ala Ala Leu Asp Gly Gly Glu Glu Gly Met Asp 
            260                 265                 270         


Ile Ile Thr His Ile Leu Ala Leu Ala Pro Arg Leu Leu Lys Asp Ser 
        275                 280                 285             


Gly Ser Ile Phe Leu Glu Val Asp Pro Arg His Pro Glu Leu Val Ser 
    290                 295                 300                 


Ser Trp Leu Gln Ser Arg Pro Asp Leu Tyr Leu Asn Leu Val Ala Val 
305                 310                 315                 320 


Arg Arg Asp Phe Cys Gly Arg Pro Arg Phe Leu His Ile Arg Arg Ser 
                325                 330                 335     


Gly Pro 
        


<210> 8146
<211> 372
<212> PRT
<213> Homo sapiens

<400> 8146
Met Lys Arg Arg Thr Asp Pro Glu Cys Thr Ala Pro Ile Lys Lys Gln 
1               5                   10                  15      


Lys Lys Arg Val Ala Glu Leu Ala Leu Ser Leu Ser Ser Thr Ser Asp 
            20                  25                  30          


Asp Glu Pro Pro Ser Ser Val Ser His Gly Ala Lys Ala Ser Thr Thr 
        35                  40                  45              


Ser Leu Ser Gly Ser Asp Ser Glu Thr Glu Gly Lys Gln His Ser Ser 
    50                  55                  60                  


Asp Ser Phe Asp Asp Ala Phe Lys Ala Asp Ser Leu Val Glu Gly Thr 
65                  70                  75                  80  


Ser Ser Arg Tyr Ser Met Tyr Asn Ser Val Ser Gln Lys Leu Met Ala 
                85                  90                  95      


Lys Met Gly Phe Arg Glu Gly Glu Gly Leu Gly Lys Tyr Ser Gln Gly 
            100                 105                 110         


Arg Lys Asp Ile Val Glu Ala Ser Ser Gln Lys Gly Arg Arg Gly Leu 
        115                 120                 125             


Gly Leu Thr Leu Arg Gly Phe Asp Gln Glu Leu Asn Val Asp Trp Arg 
    130                 135                 140                 


Asp Glu Pro Glu Pro Ser Ala Cys Glu Gln Val Ser Trp Phe Pro Glu 
145                 150                 155                 160 


Cys Thr Thr Glu Ile Pro Asp Thr Gln Glu Met Ser Asp Trp Met Val 
                165                 170                 175     


Val Gly Lys Arg Lys Met Ile Ile Glu Asp Glu Thr Glu Phe Cys Gly 
            180                 185                 190         


Glu Glu Leu Leu His Ser Val Leu Gln Cys Lys Lys Pro Leu Val Lys 
        195                 200                 205             


Asp Arg Glu Ala Glu Leu Leu Tyr Phe Ala Asp Val Cys Ala Gly Pro 
    210                 215                 220                 


Gly Gly Phe Ser Glu Tyr Val Leu Trp Arg Lys Lys Trp His Ala Lys 
225                 230                 235                 240 


Gly Phe Gly Met Thr Leu Lys Gly Pro Asn Asp Phe Lys Leu Glu Asp 
                245                 250                 255     


Phe Tyr Ser Ala Ser Ser Glu Leu Phe Glu Pro Tyr Tyr Gly Glu Gly 
            260                 265                 270         


Gly Ile Asp Gly Asp Gly Asp Ile Thr Arg Pro Glu Asn Ile Ser Ala 
        275                 280                 285             


Phe Arg Asn Phe Val Leu Asp Asn Thr Asp Arg Lys Gly Val His Phe 
    290                 295                 300                 


Leu Met Ala Asp Gly Gly Phe Ser Val Glu Gly Gln Glu Asn Leu Gln 
305                 310                 315                 320 


Glu Ile Leu Ser Lys Gln Leu Leu Leu Cys Gln Phe Leu Met Ala Leu 
                325                 330                 335     


Ser Ile Val Arg Thr Gly Gly His Phe Ile Cys Lys Thr Phe Asp Leu 
            340                 345                 350         


Phe Thr Pro Phe Ser Val Gly Leu Val Tyr Leu Leu Tyr Cys Cys Phe 
        355                 360                 365             


Glu Arg Val Cys 
    370         


<210> 8147
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8147
Xaa Gln Leu Ala Ser Met Val Trp Asn Asn Pro Ser Gln Gln Gln Phe 
1               5                   10                  15      


Met Gln Phe Gly Gly Ser Ser Gly Ser Gln Leu Pro Gln Ile Gln Thr 
            20                  25                  30          


Asp Val Val Leu Pro Ser Cys Lys Lys Lys Ala Pro Ala Glu Thr Pro 
        35                  40                  45              


Val Lys Glu Arg Leu Phe Ile Val Phe Asn Pro His Pro Leu Pro Leu 
    50                  55                  60                  


Asp Val Leu Glu Asp Ile Phe Cys Arg Phe Gly Asn Leu Ile Glu Val 
65                  70                  75                  80  


Tyr Leu Val Ser Gly Lys Asn Val Gly Tyr Ala Lys Tyr Ala Asp Arg 
                85                  90                  95      


Ile Ser Ala Asn Asp Ala Ile Ala Thr Leu His Gly Lys Ile Leu Asn 
            100                 105                 110         


Gly Val Arg Leu Lys Val Met Leu Ala Asp Ser Pro Arg Glu Glu Ser 
        115                 120                 125             


Asn Lys Arg Gln Arg Thr Tyr 
    130                 135 


<210> 8148
<211> 587
<212> PRT
<213> Homo sapiens

<400> 8148
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe 
        35                  40                  45              


Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu 
    50                  55                  60                  


Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys 
65                  70                  75                  80  


Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile 
                85                  90                  95      


Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile Thr Ala Gly Ala 
            100                 105                 110         


Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe Gly Pro Asp Gly 
        115                 120                 125             


Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser Ala Cys Phe Thr Leu 
    130                 135                 140                 


Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile Gly Gly Gly Lys 
145                 150                 155                 160 


Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys Ser Ser Ala Gln 
                165                 170                 175     


Gly Lys Pro Leu Ala Leu Lys Val Phe Val Ala Gly Arg Asn Arg Leu 
            180                 185                 190         


Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe Arg Val Ile Gly 
        195                 200                 205             


Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile Asn His Pro Gly 
    210                 215                 220                 


Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro Leu Leu Arg Val 
225                 230                 235                 240 


Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly Ala Val Ala Met 
                245                 250                 255     


Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val Ile Asn Phe Gly 
            260                 265                 270         


Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile Ala Asp Ala Ile 
        275                 280                 285             


Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu Ser Phe Cys Glu 
    290                 295                 300                 


Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala Met Ala Asp Lys 
305                 310                 315                 320 


Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr Leu Gly Glu Glu 
                325                 330                 335     


Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe Asn Met Ala Lys 
            340                 345                 350         


Val Leu Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Asp Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Gln Gln 
385                 390                 395                 400 


Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg Lys Ile Leu Asp 
                405                 410                 415     


Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser Pro Pro Pro Ala 
            420                 425                 430         


Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu Lys Leu Leu Arg 
        435                 440                 445             


Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln Thr Asp Thr Ser 
    450                 455                 460                 


Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val Ser Ser Val Phe 
465                 470                 475                 480 


Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp Ala Val Asp Ala 
                485                 490                 495     


Leu Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn Ser Asn Thr Phe 
            500                 505                 510         


Leu Thr Arg Leu Leu Val His Met Gly Leu Leu Lys Ser Glu Asp Lys 
        515                 520                 525             


Val Lys Ala Ile Ala Asn Leu Tyr Gly Pro Leu Met Ala Leu Asn His 
    530                 535                 540                 


Met Val Gln Gln Asp Tyr Phe Pro Lys Ala Leu Ala Pro Leu Leu Leu 
545                 550                 555                 560 


Ala Phe Val Thr Lys Pro Asn Ser Ala Leu Glu Ser Cys Ser Phe Ala 
                565                 570                 575     


Arg His Ser Leu Leu Gln Thr Leu Tyr Lys Val 
            580                 585         


<210> 8149
<211> 613
<212> PRT
<213> Homo sapiens

<400> 8149
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210> 8150
<211> 158
<212> PRT
<213> Homo sapiens

<400> 8150
Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys Arg Thr 
1               5                   10                  15      


Thr Cys Cys Arg Thr Thr Cys Trp Lys Pro Thr Thr Val Thr Thr Cys 
            20                  25                  30          


Ser Ser Thr Pro Cys Cys Gln Pro Ala Cys Cys Val Ser Ser Cys Cys 
        35                  40                  45              


Gln Pro Cys Cys Arg Pro Thr Cys Cys Gln Asn Thr Cys Cys Arg Thr 
    50                  55                  60                  


Thr Cys Cys Gln Pro Thr Cys Pro Thr Cys Cys Gly Ser Ser Cys Cys 
65                  70                  75                  80  


Gly Gln Thr Ser Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser Cys Ala 
                85                  90                  95      


Pro Val Tyr Cys Arg Arg Thr Cys Tyr Tyr Pro Thr Thr Val Cys Leu 
            100                 105                 110         


Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Asn Cys Cys Gln Pro Cys 
        115                 120                 125             


Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr Cys Phe 
    130                 135                 140                 


Gln Pro Thr Cys Val Ser Ser Cys Cys Gln Pro Ser Cys Cys 
145                 150                 155             


<210> 8151
<211> 539
<212> PRT
<213> Homo sapiens

<400> 8151
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 8152
<211> 836
<212> PRT
<213> Homo sapiens

<400> 8152
Met Ala Ala Ala Leu Gly Pro Pro Glu Val Ile Ala Gln Leu Glu Asn 
1               5                   10                  15      


Ala Ala Lys Val Leu Met Gln Thr Leu Ala Cys Ser Ile Leu Thr Ala 
            20                  25                  30          


Leu Leu Ser Glu Phe Ser Ser Ser Ser Lys Thr Ser Asn Ile Gly Leu 
        35                  40                  45              


Ser Met Glu Phe His Gly Asn Cys Lys Arg Val Phe Gln Glu Glu Asp 
    50                  55                  60                  


Leu Arg Gln Ile Phe Met Leu Thr Val Glu Val Leu Gln Glu Phe Ser 
65                  70                  75                  80  


Arg Arg Glu Asn Leu Asn Ala Gln Met Ser Ser Val Phe Gln Arg Tyr 
                85                  90                  95      


Leu Ala Leu Ala Asn Gln Val Leu Ser Trp Asn Phe Leu Pro Pro Lys 
            100                 105                 110         


Leu Gly Arg His Tyr Ile Ala Met Phe Glu Ser Ser Gln Asn Val Leu 
        115                 120                 125             


Leu Lys Pro Thr Glu Ser Trp Arg Glu Thr Leu Leu Asp Ser Arg Val 
    130                 135                 140                 


Met Glu Leu Phe Phe Thr Val His Arg Lys Ile Arg Glu Asp Ser Asp 
145                 150                 155                 160 


Met Ala Gln Asp Ser Leu Gln Cys Leu Ala Gln Leu Ala Ser Leu His 
                165                 170                 175     


Gly Pro Ile Phe Pro Asp Glu Gly Ser Gln Val Asp Tyr Leu Ala His 
            180                 185                 190         


Phe Ile Glu Gly Leu Leu Asn Thr Ile Asn Gly Ile Glu Ile Glu Asp 
        195                 200                 205             


Ser Glu Ala Val Gly Ile Ser Ser Ile Ile Ser Asn Leu Ile Thr Val 
    210                 215                 220                 


Phe Pro Arg Asn Val Leu Thr Ala Ile Pro Ser Glu Leu Phe Ser Ser 
225                 230                 235                 240 


Phe Val Asn Cys Leu Thr His Leu Thr Cys Ser Phe Gly Arg Ser Ala 
                245                 250                 255     


Ala Leu Glu Glu Val Leu Asp Lys Asp Asp Met Val Tyr Met Glu Ala 
            260                 265                 270         


Tyr Asp Lys Leu Leu Glu Ser Trp Leu Thr Leu Val Gln Asp Asp Lys 
        275                 280                 285             


His Phe His Lys Gly Phe Phe Thr Gln His Ala Val Gln Val Phe Asn 
    290                 295                 300                 


Ser Tyr Ile Gln Cys His Leu Ala Ala Pro Asp Gly Thr Arg Asn Leu 
305                 310                 315                 320 


Thr Ala Asn Gly Val Ala Ser Arg Glu Glu Glu Glu Ile Ser Glu Leu 
                325                 330                 335     


Gln Glu Asp Asp Arg Asp Gln Phe Ser Asp Gln Leu Ala Ser Val Gly 
            340                 345                 350         


Met Leu Gly Arg Ile Ala Ala Glu His Cys Ile Pro Leu Leu Thr Ser 
        355                 360                 365             


Leu Leu Glu Glu Arg Val Thr Arg Leu His Gly Gln Leu Gln Arg His 
    370                 375                 380                 


Gln Gln Gln Leu Leu Ala Ser Pro Gly Ser Ser Thr Val Asp Asn Lys 
385                 390                 395                 400 


Met Leu Asp Asp Leu Tyr Glu Asp Ile His Trp Leu Ile Leu Val Thr 
                405                 410                 415     


Gly Tyr Leu Leu Ala Asp Asp Thr Gln Gly Glu Thr Pro Leu Ile Pro 
            420                 425                 430         


Pro Glu Ile Met Glu Tyr Ser Ile Lys His Ser Ser Glu Val Asp Ile 
        435                 440                 445             


Asn Thr Thr Leu Gln Ile Leu Gly Ser Pro Gly Glu Lys Ala Ser Ser 
    450                 455                 460                 


Ile Pro Gly Tyr Asn Arg Thr Asp Ser Val Ile Arg Leu Leu Ser Ala 
465                 470                 475                 480 


Ile Leu Arg Val Ser Glu Val Glu Ser Arg Ala Ile Arg Ala Asp Leu 
                485                 490                 495     


Thr His Leu Leu Ser Pro Gln Met Gly Lys Asp Ile Val Trp Phe Leu 
            500                 505                 510         


Lys Arg Trp Ala Lys Thr Tyr Leu Leu Val Asp Glu Lys Leu Tyr Asp 
        515                 520                 525             


Gln Ile Ser Leu Pro Phe Ser Thr Ala Phe Gly Ala Asp Thr Glu Gly 
    530                 535                 540                 


Ser Gln Trp Ile Ile Gly Tyr Leu Leu Gln Lys Val Ile Ser Asn Leu 
545                 550                 555                 560 


Ser Val Trp Ser Ser Glu Gln Asp Leu Ala Asn Asp Thr Val Gln Leu 
                565                 570                 575     


Leu Val Thr Leu Val Glu Arg Arg Glu Arg Ala Asn Leu Val Ile Gln 
            580                 585                 590         


Cys Glu Asn Trp Trp Asn Leu Ala Lys Gln Phe Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Leu Asn Phe Leu Ser Ser Pro Val Gln Arg Thr Leu Met Lys Ala 
    610                 615                 620                 


Leu Val Leu Gly Gly Phe Ala His Met Asp Thr Glu Thr Lys Gln Gln 
625                 630                 635                 640 


Tyr Trp Thr Glu Val Leu Gln Pro Leu Gln Gln Arg Phe Leu Arg Val 
                645                 650                 655     


Ile Asn Gln Glu Asn Phe Gln Gln Met Cys Gln Gln Glu Glu Val Lys 
            660                 665                 670         


Gln Glu Ile Thr Ala Thr Leu Glu Ala Leu Cys Gly Ile Ala Glu Ala 
        675                 680                 685             


Thr Gln Ile Asp Asn Val Ala Ile Leu Phe Asn Phe Leu Met Asp Phe 
    690                 695                 700                 


Leu Thr Asn Cys Ile Gly Leu Met Glu Val Tyr Lys Asn Thr Pro Glu 
705                 710                 715                 720 


Thr Val Asn Leu Ile Ile Glu Val Phe Val Glu Val Ala His Lys Gln 
                725                 730                 735     


Ile Cys Tyr Leu Gly Glu Ser Lys Ala Met Asn Leu Tyr Glu Ala Cys 
            740                 745                 750         


Leu Thr Leu Leu Gln Val Tyr Ser Lys Asn Asn Leu Gly Arg Gln Arg 
        755                 760                 765             


Ile Asp Val Thr Ala Glu Glu Glu Gln Tyr Gln Asp Leu Leu Leu Ile 
    770                 775                 780                 


Met Glu Leu Leu Thr Asn Leu Leu Ser Lys Glu Phe Ile Asp Phe Ser 
785                 790                 795                 800 


Asp Thr Asp Glu Val Phe Arg Gly His Glu Pro Gly Gln Ala Ala Asn 
                805                 810                 815     


Arg Ser Val Ser Ala Ala Asp Val Val Leu Tyr Gly Val Asn Leu Ile 
            820                 825                 830         


Leu Pro Leu Met 
        835     


<210> 8153
<211> 335
<212> PRT
<213> Homo sapiens

<400> 8153
Met Asp Phe Leu Leu Gly Asn Pro Phe Ser Ser Pro Val Gly Gln Arg 
1               5                   10                  15      


Ile Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Ala Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe 
    50                  55                  60                  


His Glu Val Leu Glu Thr Cys Val Lys Asn Cys Gly His Arg Phe His 
65                  70                  75                  80  


Val Leu Val Ala Ser Gln Asp Phe Val Glu Ser Val Leu Val Arg Thr 
                85                  90                  95      


Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile Val His Asp Lys Val Leu 
            100                 105                 110         


Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe Arg Ser Ser Pro Asp Leu 
        115                 120                 125             


Thr Gly Val Val Thr Ile Tyr Glu Asp Leu Arg Arg Lys Gly Leu Glu 
    130                 135                 140                 


Phe Pro Met Thr Asp Leu Asp Met Leu Ser Pro Ile His Thr Pro Gln 
145                 150                 155                 160 


Arg Thr Val Phe Asn Ser Glu Thr Gln Ser Gly Gln Asp Ser Val Gly 
                165                 170                 175     


Thr Asp Ser Ser Gln Gln Glu Asp Ser Gly Gln His Ala Ala Pro Leu 
            180                 185                 190         


Pro Ala Pro Pro Ile Leu Ser Gly Asp Thr Pro Ile Ala Pro Thr Pro 
        195                 200                 205             


Glu Gln Ile Gly Lys Leu Arg Ser Glu Leu Glu Met Val Ser Gly Asn 
    210                 215                 220                 


Val Arg Val Met Ser Glu Met Leu Thr Glu Leu Val Pro Thr Gln Ala 
225                 230                 235                 240 


Glu Pro Ala Asp Leu Glu Leu Leu Gln Glu Leu Asn Arg Thr Cys Arg 
                245                 250                 255     


Ala Met Gln Gln Arg Val Leu Glu Leu Ile Pro Gln Ile Ala Asn Glu 
            260                 265                 270         


Gln Leu Thr Glu Glu Leu Leu Ile Val Asn Asp Asn Leu Asn Asn Val 
        275                 280                 285             


Phe Leu Arg His Glu Arg Phe Glu Arg Phe Arg Thr Gly Gln Thr Thr 
    290                 295                 300                 


Lys Ala Pro Ser Glu Ala Glu Pro Ala Ala Asp Leu Ile Asp Met Gly 
305                 310                 315                 320 


Pro Asp Pro Ala Ala Thr Gly Asn Leu Ser Ser Gln Leu Ala Gly 
                325                 330                 335 


<210> 8154
<211> 1730
<212> PRT
<213> Homo sapiens

<400> 8154
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys 
    50                  55                  60                  


Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Pro Thr Cys Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr 
                85                  90                  95      


Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr 
            100                 105                 110         


Glu Asn Gly Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile 
        115                 120                 125             


Thr Ser Arg Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn 
    130                 135                 140                 


Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg 
145                 150                 155                 160 


Val Leu Ile Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu 
                165                 170                 175     


Phe His Asn Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser 
            180                 185                 190         


Glu Pro Val Gln Leu Leu Arg Tyr Ser Pro Thr Leu Ala Ser Glu Thr 
        195                 200                 205             


Ser Pro Val Pro Glu Ala Arg Arg Gly Ser Ser Ala Asp Ser Leu Pro 
    210                 215                 220                 


Ser His Arg Pro Ser Pro Thr Asp Ser Arg Leu Arg Ser Ser Lys Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Ser Glu Ser Ser Trp Tyr Asp Ser Pro Trp Gly Asn 
                245                 250                 255     


Ala Gly Glu Leu Ser Glu Ala Glu Gly Ser Phe Leu Ala Pro Gly Met 
            260                 265                 270         


Pro Asp Pro Ser Leu His Ala Ser Phe Pro Pro Gly Asp Ala Lys Lys 
        275                 280                 285             


Pro Phe Asn Gln Ser Ser Ser Leu Ser Ser Leu Arg Glu Leu Tyr Lys 
    290                 295                 300                 


Asp Ala Asn Leu Gly Ser Leu Ser Pro Ser Gly Ile Arg Leu Ser Asp 
305                 310                 315                 320 


Glu Tyr Met Gly Thr His Ala Ser Leu Ser Asn Arg Val Ser Phe Ala 
                325                 330                 335     


Ser Asp Ile Asp Val Pro Ser Arg Val Ala His Gly Asp Pro Ile Gln 
            340                 345                 350         


Tyr Ser Ser Phe Thr Leu Pro Cys Arg Lys Pro Lys Ala Phe Val Glu 
        355                 360                 365             


Asp Thr Ala Lys Lys Asp Ser Leu Lys Ala Arg Met Arg Arg Ile Ser 
    370                 375                 380                 


Asp Trp Thr Gly Ser Leu Ser Arg Lys Lys Arg Lys Leu Gln Glu Pro 
385                 390                 395                 400 


Arg Ser Lys Glu Gly Ser Asp Tyr Phe Asp Ser Arg Ser Asp Gly Leu 
                405                 410                 415     


Asn Thr Asp Val Gln Gly Ser Ser Gln Ala Ser Ala Phe Leu Trp Ser 
            420                 425                 430         


Gly Gly Ser Thr Gln Ile Leu Ser Gln Arg Ser Glu Ser Thr His Ala 
        435                 440                 445             


Ile Gly Ser Asp Pro Leu Arg Gln Asn Ile Tyr Glu Asn Phe Met Arg 
    450                 455                 460                 


Glu Leu Glu Met Ser Arg Thr Asn Thr Glu Asn Ile Glu Thr Ser Thr 
465                 470                 475                 480 


Glu Thr Ala Glu Ser Ser Ser Glu Ser Leu Ser Ser Leu Glu Gln Leu 
                485                 490                 495     


Asp Leu Leu Phe Glu Lys Glu Gln Gly Val Val Arg Lys Ala Gly Trp 
            500                 505                 510         


Leu Phe Phe Lys Pro Leu Val Thr Val Gln Lys Glu Arg Lys Leu Glu 
        515                 520                 525             


Leu Val Ala Arg Arg Lys Trp Lys Gln Tyr Trp Val Thr Leu Lys Gly 
    530                 535                 540                 


Cys Thr Leu Leu Phe Tyr Glu Thr Tyr Gly Lys Asn Ser Met Asp Gln 
545                 550                 555                 560 


Ser Ser Ala Pro Arg Cys Ala Leu Phe Ala Glu Asp Ser Ile Val Gln 
                565                 570                 575     


Ser Val Pro Glu His Pro Lys Lys Glu Asn Val Phe Cys Leu Ser Asn 
            580                 585                 590         


Ser Phe Gly Asp Val Tyr Leu Phe Gln Ala Thr Ser Gln Thr Asp Leu 
        595                 600                 605             


Glu Asn Trp Val Thr Ala Val His Ser Ala Cys Ala Ser Leu Phe Ala 
    610                 615                 620                 


Lys Lys His Gly Lys Glu Asp Thr Leu Arg Leu Leu Lys Asn Gln Thr 
625                 630                 635                 640 


Lys Asn Leu Leu Gln Lys Ile Asp Met Asp Ser Lys Met Lys Lys Met 
                645                 650                 655     


Ala Glu Leu Gln Leu Ser Val Val Ser Asp Pro Lys Asn Arg Lys Ala 
            660                 665                 670         


Ile Glu Asn Gln Ile Gln Gln Trp Glu Gln Asn Leu Glu Lys Phe His 
        675                 680                 685             


Met Asp Leu Phe Arg Met Arg Cys Tyr Leu Ala Ser Leu Gln Gly Gly 
    690                 695                 700                 


Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala Ala Ala Ser Arg Pro Ser 
705                 710                 715                 720 


Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu Ser Val Ser Ser Phe His 
                725                 730                 735     


Ala Leu Val Cys Ser Arg Asp Asp Ser Ala Leu Arg Lys Arg Thr Leu 
            740                 745                 750         


Ser Leu Thr Gln Arg Gly Arg Asn Lys Lys Gly Ile Phe Ser Ser Leu 
        755                 760                 765             


Lys Gly Leu Asp Thr Leu Ala Arg Lys Gly Lys Glu Lys Arg Pro Ser 
    770                 775                 780                 


Ile Thr Gln Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp 
785                 790                 795                 800 


Gly Val Pro Arg Asp Asn Ala Trp Glu Ile Gln Thr Tyr Val His Phe 
                805                 810                 815     


Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val 
            820                 825                 830         


Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser 
        835                 840                 845             


His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr 
    850                 855                 860                 


Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu 
865                 870                 875                 880 


Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr 
                885                 890                 895     


Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu 
            900                 905                 910         


Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly 
        915                 920                 925             


Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu 
    930                 935                 940                 


Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu 
945                 950                 955                 960 


Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp 
                965                 970                 975     


Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser 
            980                 985                 990         


Arg Asp Gln Lys Ser Leu Leu Pro  Pro Pro Asn Gln Ser  Gln Leu Leu 
        995                 1000                 1005             


Glu Glu  Phe Leu Asp Asn Phe  Lys Lys Asn Thr Ala  Asn Asp Phe 
    1010                 1015                 1020             


Ser Asn  Val Pro Asp Ile Thr  Thr Gly Leu Lys Arg  Ser Gln Thr 
    1025                 1030                 1035             


Asp Gly  Thr Leu Asp Gln Val  Ser His Arg Glu Lys  Met Glu Gln 
    1040                 1045                 1050             


Thr Phe  Arg Ser Ala Glu Gln  Ile Thr Ala Leu Cys  Arg Ser Phe 
    1055                 1060                 1065             


Asn Asp  Ser Gln Ala Asn Gly  Met Glu Gly Pro Arg  Glu Asn Gln 
    1070                 1075                 1080             


Asp Pro  Pro Pro Arg Ser Leu  Ala Arg His Leu Ser  Asp Ala Asp 
    1085                 1090                 1095             


Arg Leu  Arg Lys Val Ile Gln  Glu Leu Val Asp Thr  Glu Lys Ser 
    1100                 1105                 1110             


Tyr Val  Lys Asp Leu Ser Cys  Leu Phe Glu Leu Tyr  Leu Glu Pro 
    1115                 1120                 1125             


Leu Gln  Asn Glu Thr Phe Leu  Thr Gln Asp Glu Met  Glu Ser Leu 
    1130                 1135                 1140             


Phe Gly  Ser Leu Pro Glu Met  Leu Glu Phe Gln Lys  Val Phe Leu 
    1145                 1150                 1155             


Glu Thr  Leu Glu Asp Gly Ile  Ser Ala Ser Ser Asp  Phe Asn Thr 
    1160                 1165                 1170             


Leu Glu  Thr Pro Ser Gln Phe  Arg Lys Leu Leu Phe  Ser Leu Gly 
    1175                 1180                 1185             


Gly Ser  Phe Leu Tyr Tyr Ala  Asp His Phe Lys Leu  Tyr Ser Gly 
    1190                 1195                 1200             


Phe Cys  Ala Asn His Ile Lys  Val Gln Lys Val Leu  Glu Arg Ala 
    1205                 1210                 1215             


Lys Thr  Asp Lys Ala Phe Lys  Ala Phe Leu Asp Ala  Arg Asn Pro 
    1220                 1225                 1230             


Thr Lys  Gln His Ser Ser Thr  Leu Glu Ser Tyr Leu  Ile Lys Pro 
    1235                 1240                 1245             


Val Gln  Arg Val Leu Lys Tyr  Pro Leu Leu Leu Lys  Glu Leu Val 
    1250                 1255                 1260             


Ser Leu  Thr Asp Gln Glu Ser  Glu Glu His Tyr His  Leu Thr Glu 
    1265                 1270                 1275             


Ala Leu  Lys Ala Met Glu Lys  Val Ala Ser His Ile  Asn Glu Met 
    1280                 1285                 1290             


Gln Lys  Ile Tyr Glu Asp Tyr  Gly Thr Val Phe Asp  Gln Leu Val 
    1295                 1300                 1305             


Ala Glu  Gln Ser Gly Thr Glu  Lys Glu Gln Pro Glu  Trp Ser Ser 
    1310                 1315                 1320             


Glu Val  Met Asp Val Leu Asp  Pro Arg Gly Lys Leu  Thr Lys Gly 
    1325                 1330                 1335             


Thr Leu  Glu Glu Pro Arg Thr  Leu Val Thr Glu Leu  Ser Met Gly 
    1340                 1345                 1350             


Glu Leu  Leu Met His Ser Thr  Val Ser Trp Leu Asn  Pro Phe Leu 
    1355                 1360                 1365             


Ser Leu  Gly Lys Ala Arg Lys  Asp Leu Glu Leu Thr  Val Phe Val 
    1370                 1375                 1380             


Phe Lys  Arg Ala Val Ile Leu  Val Tyr Lys Glu Asn  Cys Lys Leu 
    1385                 1390                 1395             


Lys Lys  Lys Leu Pro Ser Asn  Ser Arg Pro Ala His  Asn Ser Thr 
    1400                 1405                 1410             


Asp Leu  Asp Pro Phe Lys Phe  Arg Trp Leu Ile Pro  Ile Ser Ala 
    1415                 1420                 1425             


Leu Gln  Val Arg Leu Gly Asn  Pro Ala Gly Thr Glu  Asn Asn Ser 
    1430                 1435                 1440             


Ile Trp  Glu Leu Ile His Thr  Lys Ser Glu Ile Glu  Gly Arg Pro 
    1445                 1450                 1455             


Glu Thr  Ile Phe Gln Leu Cys  Cys Ser Asp Ser Glu  Ser Lys Thr 
    1460                 1465                 1470             


Asn Ile  Val Lys Val Ile Arg  Ser Ile Leu Arg Glu  Asn Phe Arg 
    1475                 1480                 1485             


Arg His  Ile Lys Cys Glu Leu  Pro Leu Glu Lys Thr  Cys Lys Asp 
    1490                 1495                 1500             


Arg Leu  Val Pro Leu Lys Asn  Arg Val Pro Val Ser  Ala Lys Leu 
    1505                 1510                 1515             


Ala Ser  Ser Arg Ser Leu Lys  Val Leu Lys Asn Ser  Ser Ser Asn 
    1520                 1525                 1530             


Glu Trp  Thr Gly Glu Thr Gly  Lys Gly Thr Leu Leu  Asp Ser Asp 
    1535                 1540                 1545             


Glu Gly  Ser Leu Ser Ser Gly  Thr Gln Ser Ser Gly  Cys Pro Thr 
    1550                 1555                 1560             


Ala Glu  Gly Arg Gln Asp Ser  Lys Ser Thr Ser Pro  Gly Lys Tyr 
    1565                 1570                 1575             


Pro His  Pro Gly Leu Ala Asp  Phe Ala Asp Asn Leu  Ile Lys Glu 
    1580                 1585                 1590             


Ser Asp  Ile Leu Ser Asp Glu  Asp Asp Asp His Arg  Gln Thr Val 
    1595                 1600                 1605             


Lys Gln  Gly Ser Pro Thr Lys  Asp Ile Glu Ile Gln  Phe Gln Arg 
    1610                 1615                 1620             


Leu Arg  Ile Ser Glu Asp Pro  Asp Val His Pro Glu  Ala Glu Gln 
    1625                 1630                 1635             


Gln Pro  Gly Pro Glu Ser Gly  Glu Gly Gln Lys Gly  Gly Glu Gln 
    1640                 1645                 1650             


Pro Lys  Leu Val Arg Gly His  Phe Cys Pro Ile Lys  Arg Lys Ala 
    1655                 1660                 1665             


Asn Ser  Thr Lys Arg Asp Arg  Gly Thr Leu Leu Lys  Ala Gln Ile 
    1670                 1675                 1680             


Arg His  Gln Ser Leu Asp Ser  Gln Ser Glu Asn Ala  Thr Ile Asp 
    1685                 1690                 1695             


Leu Asn  Ser Val Leu Glu Arg  Glu Phe Ser Val Gln  Ser Leu Thr 
    1700                 1705                 1710             


Ser Val  Val Ser Glu Glu Cys  Phe Tyr Glu Thr Glu  Ser His Gly 
    1715                 1720                 1725             


Lys Ser  
    1730 


<210> 8155
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8155
Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys 
        115 


<210> 8156
<211> 248
<212> PRT
<213> Homo sapiens

<400> 8156
Met Ala Leu Glu Val Gly Asp Met Glu Asp Gly Gln Leu Ser Asp Ser 
1               5                   10                  15      


Asp Ser Asp Met Thr Val Ala Pro Ser Asp Arg Pro Leu Gln Leu Pro 
            20                  25                  30          


Lys Val Leu Gly Gly Asp Ser Ala Met Arg Ala Phe Gln Asn Thr Ala 
        35                  40                  45              


Thr Ala Cys Ala Pro Val Ser His Tyr Arg Ala Val Glu Ser Val Asp 
    50                  55                  60                  


Ser Ser Glu Glu Ser Phe Ser Asp Ser Asp Asp Asp Ser Cys Leu Trp 
65                  70                  75                  80  


Lys Arg Lys Arg Gln Lys Cys Phe Asn Pro Pro Pro Lys Pro Glu Pro 
                85                  90                  95      


Phe Gln Phe Gly Gln Ser Ser Gln Lys Pro Pro Val Ala Gly Gly Lys 
            100                 105                 110         


Lys Ile Asn Asn Ile Trp Gly Ala Val Leu Gln Lys Leu Arg Lys Glu 
        115                 120                 125             


Ser Gln Glu His Thr Lys Asp Leu Asp Lys Glu Leu Asp Glu Tyr Met 
    130                 135                 140                 


His Gly Gly Lys Lys Met Gly Ser Lys Glu Glu Glu Asn Gly Gln Gly 
145                 150                 155                 160 


His Leu Lys Arg Lys Arg Pro Val Lys Asp Arg Leu Gly Asn Arg Pro 
                165                 170                 175     


Glu Met Asn Tyr Lys Gly Arg Tyr Glu Ile Thr Ala Glu Asp Ser Gln 
            180                 185                 190         


Glu Lys Val Ala Asp Glu Ile Ser Phe Arg Leu Gln Glu Pro Lys Lys 
        195                 200                 205             


Asp Leu Ile Ala Arg Val Val Arg Asn Lys Leu Arg Thr Phe Ser Thr 
    210                 215                 220                 


Leu Lys Thr Lys Arg Asn Met Lys Ile Lys Lys Leu Leu Gly Arg Gly 
225                 230                 235                 240 


Glu His Lys Cys Trp Gly Lys Arg 
                245             


<210> 8157
<211> 25
<212> PRT
<213> Homo sapiens

<400> 8157
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln 
            20                  25  


<210> 8158
<211> 56
<212> PRT
<213> Homo sapiens

<400> 8158
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg 
    50                  55      


<210> 8159
<211> 149
<212> PRT
<213> Homo sapiens

<400> 8159
Val Arg Glu Leu Glu Ala Glu Leu Asp Ala Glu Gln Lys Lys His Ala 
1               5                   10                  15      


Glu Ala Leu Lys Gly Val Arg Lys His Glu Arg Arg Val Lys Glu Leu 
            20                  25                  30          


Ala Tyr Gln Ala Glu Glu Asp Arg Lys Asn Leu Ala Arg Met Gln Asp 
        35                  40                  45              


Leu Val Asp Lys Leu Gln Ser Lys Val Lys Ser Tyr Lys Arg Gln Phe 
    50                  55                  60                  


Glu Glu Ala Glu Gln Gln Ala Asn Thr Asn Leu Ala Lys Tyr Arg Lys 
65                  70                  75                  80  


Ala Gln His Glu Leu Asp Asp Ala Glu Glu Arg Ala Asp Met Ala Glu 
                85                  90                  95      


Thr Gln Ala Asn Lys Leu Arg Ala Arg Thr Arg Asp Ala Leu Gly Pro 
            100                 105                 110         


Lys Val Arg Ser Gly Arg Gly Ile Ala Leu Cys Ala Gly Gly Leu Trp 
        115                 120                 125             


Gly Leu Thr Gly Ser Thr Ala His Ser Ala Ile Pro Phe Ser Ser Ala 
    130                 135                 140                 


Gln Gly Val Thr Ala 
145                 


<210> 8160
<211> 155
<212> PRT
<213> Homo sapiens

<400> 8160
Ser Asn Val Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu 
1               5                   10                  15      


Trp Ser Gln Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile 
        35                  40                  45              


Leu Ala Thr Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu 
    50                  55                  60                  


Asp Asp Pro Asp Ala Leu Lys Asp Pro Leu Tyr Gln Ile Asp Leu Gln 
65                  70                  75                  80  


Ala Thr Leu Met Thr Met Arg Gly Glu Phe Tyr Arg Pro Ser Ala Ser 
                85                  90                  95      


Lys Lys Gly Ser Leu Ser Thr Phe Ala Pro Ser Gly Pro Ala Ala Asn 
            100                 105                 110         


His Phe Ala Ala Leu Thr Gly Leu Glu Met His Phe Leu Leu Asn Leu 
        115                 120                 125             


Lys Trp His Leu Asp Pro Trp Pro Leu Ala Ser Ala Val Thr Leu Met 
    130                 135                 140                 


Thr Ile Gln Thr Arg Leu Thr Gly Ala Val Thr 
145                 150                 155 


<210> 8161
<211> 539
<212> PRT
<213> Homo sapiens

<400> 8161
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210> 8162
<211> 214
<212> PRT
<213> Homo sapiens

<400> 8162
Met Pro Ser Pro Trp Gly Trp Phe Ala Val Thr Ala Cys Gly Ala Gln 
1               5                   10                  15      


Arg Asn Asn Phe Glu Glu Pro Val Ala Leu Gln Glu Met Asp Thr Ser 
            20                  25                  30          


Asn Gly Val Leu Leu Pro Phe Tyr Asp Pro Asp Ser Ser Ile Val Tyr 
        35                  40                  45              


Leu Cys Gly Lys Gly Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp 
    50                  55                  60                  


Glu Pro Pro Phe Val His Tyr Leu Asn Thr Phe Ser Ser Lys Glu Pro 
65                  70                  75                  80  


Gln Arg Gly Met Gly Phe Met Pro Lys Arg Gly Leu Asp Val Ser Lys 
                85                  90                  95      


Cys Glu Ile Ala Arg Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro 
            100                 105                 110         


Ile Ile Met Thr Val Pro Arg Lys Ser Asp Leu Phe Gln Asp Ala Glu 
        115                 120                 125             


Pro Val Leu Ile Ser Leu Arg Asp Gly Tyr Val Pro Pro Lys His Arg 
    130                 135                 140                 


Glu Leu Arg Val Thr Lys Arg Asn Ile Leu Asp Val Arg Pro Pro Ser 
145                 150                 155                 160 


Gly Pro Arg Arg Ser Gln Ser Ala Ser Asp Ala Pro Leu Ser Gln His 
                165                 170                 175     


Thr Leu Glu Thr Leu Leu Glu Glu Ile Lys Ala Leu Arg Glu Arg Val 
            180                 185                 190         


Gln Ala Gln Glu Gln Arg Ile Thr Ala Leu Glu Asn Met Leu Cys Glu 
        195                 200                 205             


Leu Val Asp Gly Thr Asp 
    210                 


<210> 8163
<211> 229
<212> PRT
<213> Homo sapiens

<400> 8163
Met Leu Gln Leu Arg Asp Ser Val Asp Ser Ala Gly Thr Ser Pro Thr 
1               5                   10                  15      


Ala Val Leu Ala Ala Gly Glu Glu Pro Gly Ser Ile Glu Gln Ala Val 
            20                  25                  30          


Glu Glu Ile Arg Val Val Val Arg Pro Val Glu Asp Gly Glu Ile Gln 
        35                  40                  45              


Gly Val Trp Leu Leu Thr Glu Val Asp His Trp Asn Asn Glu Lys Glu 
    50                  55                  60                  


Arg Leu Val Leu Val Thr Glu Gln Ser Leu Leu Ile Cys Lys Tyr Asp 
65                  70                  75                  80  


Phe Ile Ser Leu Gln Cys Gln Gln Val Val Arg Ile Ala Leu Asn Ala 
                85                  90                  95      


Val Asp Thr Ile Ser Tyr Gly Glu Phe Gln Phe Pro Pro Lys Ser Leu 
            100                 105                 110         


Asn Lys Arg Glu Gly Phe Gly Ile Arg Ile Gln Trp Asp Lys Gln Ser 
        115                 120                 125             


Arg Pro Ser Phe Ile Asn Arg Trp Asn Pro Trp Ser Thr Asn Val Pro 
    130                 135                 140                 


Tyr Ala Thr Phe Thr Glu His Pro Met Ala Gly Ala Asp Glu Lys Thr 
145                 150                 155                 160 


Ala Ser Leu Cys Gln Leu Glu Ser Phe Lys Ala Leu Leu Ile Gln Ala 
                165                 170                 175     


Val Lys Lys Ala Gln Lys Glu Ser Pro Leu Pro Gly Gln Ala Asn Gly 
            180                 185                 190         


Val Leu Ile Leu Glu Arg Pro Leu Leu Ile Glu Thr Tyr Val Gly Leu 
        195                 200                 205             


Met Ser Phe Ile Asn Asn Glu Ala Lys Leu Gly Tyr Ser Met Thr Arg 
    210                 215                 220                 


Gly Lys Ile Gly Phe 
225                 


<210> 8164
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8164
Met Cys Glu Val Ser Arg Gly Trp Lys Pro Cys Thr Glu Gly Ile Leu 
1               5                   10                  15      


Lys Val Arg Pro Thr Arg Lys Ile Ser Tyr Glu Gly Asn Ile Thr Pro 
            20                  25                  30          


Thr Val Glu Leu Asn Ala Leu Cys Met Lys Leu Gly Lys Lys Pro Met 
        35                  40                  45              


Tyr Lys Pro Val Asp Pro Tyr Ser Arg Met Gln Ser Thr Tyr Asn Tyr 
    50                  55                  60                  


Asn Met Arg Gly Gly Ala Tyr Pro Pro Arg Tyr Phe Tyr Pro Phe Pro 
65                  70                  75                  80  


Val Pro Pro Leu Leu Tyr Gln Val Glu Leu Ser Val Gly Gly Gln Gln 
                85                  90                  95      


Phe Asn Gly Lys Gly Lys Thr Arg Gln Ala Ala Lys His Asp Ala Ala 
            100                 105                 110         


Ala Lys Ala Leu Arg Ile Leu Gln Asn Glu Pro Leu Pro Glu Arg Leu 
        115                 120                 125             


Glu 
    


<210> 8165
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 8165
Met Asp Leu Phe Arg Met Arg Cys Tyr Leu Ala Ser Leu Gln Gly Gly 
1               5                   10                  15      


Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala Ala Ala Ser Arg Pro Ser 
            20                  25                  30          


Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu Ser Val Ser Ser Phe His 
        35                  40                  45              


Ala Leu Val Cys Ser Arg Asp Asp Ser Ala Leu Arg Lys Arg Thr Leu 
    50                  55                  60                  


Ser Leu Thr Gln Arg Gly Arg Asn Lys Lys Gly Ile Phe Ser Ser Leu 
65                  70                  75                  80  


Lys Gly Leu Asp Thr Leu Ala Arg Lys Gly Lys Glu Lys Arg Pro Ser 
                85                  90                  95      


Ile Thr Gln Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp 
            100                 105                 110         


Gly Val Pro Arg Asp Asn Ala Trp Glu Ile Gln Thr Tyr Val His Phe 
        115                 120                 125             


Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val 
    130                 135                 140                 


Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser 
145                 150                 155                 160 


His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr 
                165                 170                 175     


Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu 
            180                 185                 190         


Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr 
        195                 200                 205             


Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu 
    210                 215                 220                 


Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly 
225                 230                 235                 240 


Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu 
                245                 250                 255     


Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu 
            260                 265                 270         


Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp 
        275                 280                 285             


Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser 
    290                 295                 300                 


Arg Asp Gln Lys Ser Leu Leu Pro Pro Pro Asn Gln Ser Gln Leu Leu 
305                 310                 315                 320 


Glu Glu Phe Leu Asp Asn Phe Lys Lys Asn Thr Ala Asn Asp Phe Ser 
                325                 330                 335     


Asn Val Pro Asp Ile Thr Thr Gly Leu Lys Arg Ser Gln Thr Asp Gly 
            340                 345                 350         


Thr Leu Asp Gln Val Ser His Arg Glu Lys Met Glu Gln Thr Phe Arg 
        355                 360                 365             


Ser Ala Glu Gln Ile Thr Ala Leu Cys Arg Ser Phe Asn Asp Ser Gln 
    370                 375                 380                 


Ala Asn Gly Met Glu Gly Pro Arg Glu Asn Gln Asp Pro Pro Pro Arg 
385                 390                 395                 400 


Ser Leu Ala Arg His Leu Ser Asp Ala Asp Arg Leu Arg Lys Val Ile 
                405                 410                 415     


Gln Glu Leu Val Asp Thr Glu Lys Ser Tyr Val Lys Asp Leu Ser Cys 
            420                 425                 430         


Leu Phe Glu Leu Tyr Leu Glu Pro Leu Gln Asn Glu Thr Phe Leu Thr 
        435                 440                 445             


Gln Asp Glu Met Glu Ser Leu Phe Gly Ser Leu Pro Glu Met Leu Glu 
    450                 455                 460                 


Phe Gln Lys Val Phe Leu Glu Thr Leu Glu Asp Gly Ile Ser Ala Ser 
465                 470                 475                 480 


Ser Asp Phe Asn Thr Leu Glu Thr Pro Ser Gln Phe Arg Lys Leu Leu 
                485                 490                 495     


Phe Ser Leu Gly Gly Ser Phe Leu Tyr Tyr Ala Asp His Phe Lys Leu 
            500                 505                 510         


Tyr Ser Gly Phe Cys Ala Asn His Ile Lys Val Gln Lys Val Leu Glu 
        515                 520                 525             


Arg Ala Lys Thr Asp Lys Ala Phe Lys Ala Phe Leu Asp Ala Arg Asn 
    530                 535                 540                 


Pro Thr Lys Gln His Ser Ser Thr Leu Glu Ser Tyr Leu Ile Lys Pro 
545                 550                 555                 560 


Val Gln Arg Val Leu Lys Tyr Pro Leu Leu Leu Lys Glu Leu Val Ser 
                565                 570                 575     


Leu Thr Asp Gln Glu Ser Glu Glu His Tyr His Leu Thr Glu Ala Leu 
            580                 585                 590         


Lys Ala Met Glu Lys Val Ala Ser His Ile Asn Glu Met Gln Lys Ile 
        595                 600                 605             


Tyr Glu Asp Tyr Gly Thr Val Phe Asp Gln Leu Val Ala Glu Gln Ser 
    610                 615                 620                 


Gly Thr Glu Lys Glu Val Thr Glu Leu Ser Met Gly Glu Leu Leu Met 
625                 630                 635                 640 


His Ser Thr Val Ser Trp Leu Asn Pro Phe Leu Ser Leu Gly Lys Ala 
                645                 650                 655     


Arg Lys Asp Leu Glu Leu Thr Val Phe Val Phe Lys Arg Ala Val Ile 
            660                 665                 670         


Leu Val Tyr Lys Glu Asn Cys Lys Leu Lys Lys Lys Leu Pro Ser Asn 
        675                 680                 685             


Ser Arg Pro Ala His Asn Ser Thr Asp Leu Asp Pro Phe Lys Phe Arg 
    690                 695                 700                 


Trp Leu Ile Pro Ile Ser Ala Leu Gln Val Arg Leu Gly Asn Pro Ala 
705                 710                 715                 720 


Gly Thr Glu Asn Asn Ser Ile Trp Glu Leu Ile His Thr Lys Ser Glu 
                725                 730                 735     


Ile Glu Gly Arg Pro Glu Thr Ile Phe Gln Leu Cys Cys Ser Asp Ser 
            740                 745                 750         


Glu Ser Lys Thr Asn Ile Val Lys Val Ile Arg Ser Ile Leu Arg Glu 
        755                 760                 765             


Asn Phe Arg Arg His Ile Lys Cys Glu Leu Pro Leu Glu Lys Thr Cys 
    770                 775                 780                 


Lys Asp Arg Leu Val Pro Leu Lys Asn Arg Val Pro Val Ser Ala Lys 
785                 790                 795                 800 


Leu Ala Ser Ser Arg Ser Leu Lys Val Leu Lys Asn Ser Ser Ser Asn 
                805                 810                 815     


Glu Trp Thr Gly Glu Thr Gly Lys Gly Thr Leu Leu Asp Ser Asp Glu 
            820                 825                 830         


Gly Ser Leu Ser Ser Gly Thr Gln Ser Ser Gly Cys Pro Thr Ala Glu 
        835                 840                 845             


Gly Arg Gln Asp Ser Lys Ser Thr Ser Pro Gly Lys Tyr Pro His Pro 
    850                 855                 860                 


Gly Leu Ala Asp Phe Ala Asp Asn Leu Ile Lys Glu Ser Asp Ile Leu 
865                 870                 875                 880 


Ser Asp Glu Asp Asp Asp His Arg Gln Thr Val Lys Gln Gly Ser Pro 
                885                 890                 895     


Thr Lys Asp Ile Glu Ile Gln Phe Gln Arg Leu Arg Ile Ser Glu Asp 
            900                 905                 910         


Pro Asp Val His Pro Glu Ala Glu Gln Gln Pro Gly Pro Glu Ser Gly 
        915                 920                 925             


Glu Gly Gln Lys Gly Gly Glu Gln Pro Lys Leu Val Arg Gly His Phe 
    930                 935                 940                 


Cys Pro Ile Lys Arg Lys Ala Asn Ser Thr Lys Arg Asp Arg Gly Thr 
945                 950                 955                 960 


Leu Leu Lys Ala Gln Ile Arg His Gln Ser Leu Asp Ser Gln Ser Glu 
                965                 970                 975     


Asn Ala Thr Ile Asp Leu Asn Ser Val Leu Glu Arg Glu Phe Ser Val 
            980                 985                 990         


Gln Ser Leu Thr Ser Val Val Ser  Glu Glu Cys Phe Tyr  Glu Thr Glu 
        995                 1000                 1005             


Ser His  Gly Lys Ser 
    1010             


<210> 8166
<211> 382
<212> PRT
<213> Homo sapiens

<400> 8166
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ser Val 
            100                 105                 110         


Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys Asp 
        115                 120                 125             


Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu 
    130                 135                 140                 


Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg 
145                 150                 155                 160 


Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln 
                165                 170                 175     


Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu Gln Gln 
            180                 185                 190         


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
        195                 200                 205             


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
    210                 215                 220                 


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
225                 230                 235                 240 


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
                245                 250                 255     


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
            260                 265                 270         


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
        275                 280                 285             


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
    290                 295                 300                 


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
305                 310                 315                 320 


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
                325                 330                 335     


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
            340                 345                 350         


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
        355                 360                 365             


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
    370                 375                 380         


<210> 8167
<211> 219
<212> PRT
<213> Homo sapiens

<400> 8167
Met Val Val Leu Ser Val Pro Ala Glu Val Thr Val Ile Leu Leu Asp 
1               5                   10                  15      


Ile Glu Gly Thr Thr Thr Pro Ile Ala Phe Val Lys Asp Ile Leu Phe 
            20                  25                  30          


Pro Tyr Ile Glu Glu Asn Val Lys Glu Tyr Leu Gln Thr His Trp Glu 
        35                  40                  45              


Glu Glu Glu Cys Gln Gln Asp Val Ser Leu Leu Arg Lys Gln Ala Glu 
    50                  55                  60                  


Glu Asp Ala His Leu Asp Gly Ala Val Pro Ile Pro Ala Ala Ser Gly 
65                  70                  75                  80  


Asn Gly Val Asp Asp Leu Gln Gln Met Ile Gln Ala Val Val Asp Asn 
                85                  90                  95      


Val Cys Trp Gln Met Ser Leu Asp Arg Lys Thr Thr Ala Leu Lys Gln 
            100                 105                 110         


Leu Gln Gly His Met Trp Arg Ala Ala Phe Thr Ala Gly Arg Met Lys 
        115                 120                 125             


Ala Glu Phe Phe Ala Asp Val Val Pro Ala Val Arg Lys Trp Arg Glu 
    130                 135                 140                 


Ala Gly Met Lys Val Tyr Ile Tyr Ser Ser Gly Ser Val Glu Ala Gln 
145                 150                 155                 160 


Lys Leu Leu Phe Gly His Ser Thr Glu Gly Asp Ile Leu Glu Leu Val 
                165                 170                 175     


Asp Gly His Phe Asp Thr Lys Ile Gly His Lys Val Glu Ser Glu Ser 
            180                 185                 190         


Tyr Lys Asp Cys Arg Gln His Trp Val Leu Asn Gln Gln His Phe Val 
        195                 200                 205             


Ser Asp Arg Cys Tyr Ser Arg Gly Gln Cys Cys 
    210                 215                 


<210> 8168
<211> 481
<212> PRT
<213> Homo sapiens

<400> 8168
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 8169
<211> 547
<212> PRT
<213> Homo sapiens

<400> 8169
Met Ala Gly Thr Lys Asn Lys Thr Arg Ala Gln Ala Lys Thr Glu Lys 
1               5                   10                  15      


Lys Ala Ala Ile Gln Ala Lys Ala Gly Ala Glu Arg Glu Ala Thr Gly 
            20                  25                  30          


Val Val Arg Pro Val Ala Lys Thr Arg Ala Lys Ala Lys Ala Lys Thr 
        35                  40                  45              


Gly Ser Lys Thr Asp Ala Val Ala Glu Met Lys Ala Val Ser Lys Asn 
    50                  55                  60                  


Lys Val Val Ala Glu Thr Lys Glu Gly Ala Leu Ser Glu Pro Lys Thr 
65                  70                  75                  80  


Leu Gly Lys Ala Met Gly Asp Phe Thr Pro Lys Ala Gly Asn Glu Ser 
                85                  90                  95      


Thr Ser Ser Thr Cys Lys Asn Glu Ala Gly Thr Asp Ala Trp Phe Trp 
            100                 105                 110         


Ala Gly Glu Glu Ala Thr Ile Asn Ser Trp Phe Trp Asn Gly Glu Glu 
        115                 120                 125             


Ala Gly Asn Ser Phe Ser Thr Lys Asn Asp Lys Pro Glu Ile Gly Ala 
    130                 135                 140                 


Gln Val Cys Ala Glu Glu Leu Glu Pro Ala Ala Gly Ala Asp Cys Lys 
145                 150                 155                 160 


Pro Arg Ser Gly Ala Glu Glu Glu Glu Glu Glu Asn Val Ile Gly Asn 
                165                 170                 175     


Trp Phe Trp Glu Gly Asp Asp Thr Ser Phe Asp Pro Asn Pro Lys Pro 
            180                 185                 190         


Val Ser Arg Ile Val Lys Pro Gln Pro Val Tyr Glu Ile Asn Glu Lys 
        195                 200                 205             


Asn Arg Pro Lys Asp Trp Ser Glu Val Thr Ile Trp Pro Asn Ala Pro 
    210                 215                 220                 


Ala Val Thr Pro Ala Val Leu Gly Phe Arg Ser Gln Ala Pro Ser Glu 
225                 230                 235                 240 


Ala Ser Pro Pro Ser Tyr Ile Val Leu Ala Ser Ala Glu Glu Asn Ala 
                245                 250                 255     


Cys Ser Leu Pro Val Ala Thr Ala Cys Arg Pro Ser Arg Asn Thr Arg 
            260                 265                 270         


Ser Cys Ser Gln Pro Ile Pro Glu Cys Arg Phe Asp Ser Asp Pro Cys 
        275                 280                 285             


Ile Gln Thr Ile Asp Glu Ile Arg Arg Gln Ile Arg Ile Arg Glu Val 
    290                 295                 300                 


Asn Gly Ile Lys Pro Phe Ala Cys Pro Cys Lys Met Glu Cys Tyr Met 
305                 310                 315                 320 


Asp Ser Glu Glu Phe Glu Lys Leu Val Ser Leu Leu Lys Ser Thr Thr 
                325                 330                 335     


Asp Pro Leu Ile His Lys Ile Ala Arg Ile Ala Met Gly Val His Asn 
            340                 345                 350         


Val His Pro Phe Ala Gln Glu Phe Ile Asn Glu Val Gly Val Val Thr 
        355                 360                 365             


Leu Ile Glu Ser Leu Leu Ser Phe Pro Ser Pro Glu Met Arg Lys Lys 
    370                 375                 380                 


Thr Val Ile Thr Leu Asn Pro Pro Ser Gly Asp Glu Arg Gln Arg Lys 
385                 390                 395                 400 


Ile Glu Leu His Val Lys His Met Cys Lys Glu Thr Met Ser Phe Pro 
                405                 410                 415     


Leu Asn Ser Pro Gly Gln Gln Ser Gly Leu Lys Ile Leu Gly Gln Leu 
            420                 425                 430         


Thr Thr Asp Phe Val His His Tyr Ile Val Ala Asn Tyr Phe Ser Glu 
        435                 440                 445             


Leu Phe His Leu Leu Ser Ser Gly Asn Cys Lys Thr Arg Asn Leu Val 
    450                 455                 460                 


Leu Lys Leu Leu Leu Asn Met Ser Glu Asn Pro Thr Ala Ala Arg Asp 
465                 470                 475                 480 


Met Ile Asn Met Lys Ala Leu Ala Ala Leu Lys Leu Ile Phe Asn Gln 
                485                 490                 495     


Lys Glu Ala Lys Ala Asn Leu Val Ser Gly Val Ala Ile Phe Ile Asn 
            500                 505                 510         


Ile Lys Glu His Ile Arg Lys Gly Ser Ile Val Val Val Asp His Leu 
        515                 520                 525             


Ser Tyr Asn Thr Leu Met Ala Ile Phe Arg Glu Val Lys Glu Ile Ile 
    530                 535                 540                 


Glu Thr Met 
545         


<210> 8170
<211> 628
<212> PRT
<213> Homo sapiens

<400> 8170
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr Asp 
            100                 105                 110         


Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg Leu 
        115                 120                 125             


His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg 
    130                 135                 140                 


Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His 
145                 150                 155                 160 


Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val 
                165                 170                 175     


Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys 
            180                 185                 190         


Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu 
        195                 200                 205             


His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile 
    210                 215                 220                 


Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly 
225                 230                 235                 240 


Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu 
                245                 250                 255     


Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val 
            260                 265                 270         


Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala 
        275                 280                 285             


Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala 
    290                 295                 300                 


Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe 
305                 310                 315                 320 


His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro 
                325                 330                 335     


Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp 
            340                 345                 350         


Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala 
        355                 360                 365             


Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln 
    370                 375                 380                 


Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser 
385                 390                 395                 400 


Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val 
                405                 410                 415     


Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr 
            420                 425                 430         


Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr 
        435                 440                 445             


Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu 
    450                 455                 460                 


Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly 
465                 470                 475                 480 


Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr 
                485                 490                 495     


Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu 
            500                 505                 510         


Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro 
        515                 520                 525             


Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn 
    530                 535                 540                 


Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly 
545                 550                 555                 560 


Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val 
                565                 570                 575     


Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu 
            580                 585                 590         


Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu 
        595                 600                 605             


Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val 
    610                 615                 620                 


Glu Leu Ser Ala 
625             


<210> 8171
<211> 157
<212> PRT
<213> Homo sapiens

<400> 8171
Met Arg Ser Gly Phe Arg Cys Asp Glu Pro Ala Glu Ala Val Ala Pro 
1               5                   10                  15      


Glu Arg Gln Thr Val Ser Gly Ala Val Ala Leu Ala Ser Phe Thr Ser 
            20                  25                  30          


Pro His Thr His Pro Val Asp Asp Gly Gly Arg His Tyr Ser Trp Gly 
        35                  40                  45              


Ser Pro Lys Arg Ile Leu Gly Leu Gly Pro Gly Asp Ala Ala Lys Glu 
    50                  55                  60                  


Ala Gly Leu Val Arg Pro Leu Gln Gly Gln Ser Glu Lys Ile Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Asn Arg Gln Pro Met Glu Pro Pro Met Glu Pro Ser Gly 
                85                  90                  95      


Gly Glu Gln Glu Pro Gly Ala Val Arg Phe Leu Asp Leu Pro Trp Glu 
            100                 105                 110         


Asp Val Leu Leu Pro His Val Leu Asn Arg Val Pro Leu Arg Gln Leu 
        115                 120                 125             


Leu Arg Leu Gln Arg Val Ser Arg Ala Phe Arg Ser Leu Val Gln Leu 
    130                 135                 140                 


His Leu Ala Gly Leu Arg Arg Phe Asp Ala Ala Gln Val 
145                 150                 155         


<210> 8172
<211> 160
<212> PRT
<213> Homo sapiens

<400> 8172
Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210> 8173
<211> 133
<212> PRT
<213> Homo sapiens

<400> 8173
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu 
    130             


<210> 8174
<211> 212
<212> PRT
<213> Homo sapiens

<400> 8174
Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro 
1               5                   10                  15      


Ala Ala Gly Lys Glu Ala Gln Lys Gly Pro Leu Leu Phe Asp Asp Leu 
            20                  25                  30          


Pro Pro Ala Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
        35                  40                  45              


Asp Asp Leu Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr 
    50                  55                  60                  


Ser Ile Ser Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Ser Glu Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys 
                85                  90                  95      


Val Ser Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala Glu Arg 
            100                 105                 110         


Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu Asn Asp 
        115                 120                 125             


Ile Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg Val Ser 
    130                 135                 140                 


Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser Lys Phe 
145                 150                 155                 160 


Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro Lys Gly 
                165                 170                 175     


Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu Asp Thr 
            180                 185                 190         


Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser Gln Lys 
        195                 200                 205             


Pro Ala Trp Lys 
    210         


<210> 8175
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8175
Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 
1               5                   10                  15      


Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 
            20                  25                  30          


Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 
        35                  40                  45              


Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 
    50                  55                  60                  


Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 
65                  70                  75                  80  


Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 
                85                  90                  95      


Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 
            100                 105                 110         


Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 
        115                 120                 125             


Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 
    130                 135                 140                 


Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 
145                 150                 155                 160 


Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 
                165                 170                 175     


Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 
            180                 185                 190         


Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 
        195                 200                 205             


Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 
    210                 215                 220                 


Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 
225                 230                 235                 240 


Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 
                245                 250                 255     


Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 
            260                 265                 270         


Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 
        275                 280                 285             


Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 
    290                 295                 300                 


Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 
305                 310                 315                 320 


Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 
                325                 330                 335     


Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Tyr Arg 
            340                 345                 350         


Ile Met Lys Arg His Leu Arg Leu Ile His Pro Thr Lys Leu Tyr Lys 
        355                 360                 365             


Leu Met Leu Arg Arg Phe Gly Met 
    370                 375     


<210> 8176
<211> 494
<212> PRT
<213> Homo sapiens

<400> 8176
Met Ala Ala Ala Ala Glu Cys Asp Val Val Met Ala Ala Thr Glu Pro 
1               5                   10                  15      


Glu Leu Leu Asp Asp Gln Glu Ala Lys Arg Glu Ala Glu Thr Phe Lys 
            20                  25                  30          


Glu Gln Gly Asn Ala Tyr Tyr Ala Lys Lys Asp Tyr Asn Glu Ala Tyr 
        35                  40                  45              


Asn Tyr Tyr Thr Lys Ala Ile Asp Met Cys Pro Lys Asn Ala Ser Tyr 
    50                  55                  60                  


Tyr Gly Asn Arg Ala Ala Thr Leu Met Met Leu Gly Arg Phe Arg Glu 
65                  70                  75                  80  


Ala Leu Gly Asp Ala Gln Gln Ser Val Arg Leu Asp Asp Ser Phe Val 
                85                  90                  95      


Arg Gly His Leu Arg Glu Gly Lys Cys His Leu Ser Leu Gly Asn Ala 
            100                 105                 110         


Met Ala Ala Cys Arg Ser Phe Gln Arg Ala Leu Glu Leu Asp His Lys 
        115                 120                 125             


Asn Ala Gln Ala Gln Gln Glu Phe Lys Asn Ala Asn Ala Val Met Glu 
    130                 135                 140                 


Tyr Glu Lys Ile Ala Glu Thr Asp Phe Glu Lys Arg Asp Phe Arg Lys 
145                 150                 155                 160 


Val Val Phe Cys Met Asp Arg Ala Leu Glu Phe Ala Pro Ala Cys His 
                165                 170                 175     


Arg Phe Lys Ile Leu Lys Ala Glu Cys Leu Ala Met Leu Gly Arg Tyr 
            180                 185                 190         


Pro Glu Ala Gln Ser Val Ala Ser Asp Ile Leu Arg Met Asp Ser Thr 
        195                 200                 205             


Asn Ala Asp Ala Leu Tyr Val Arg Gly Leu Cys Leu Tyr Tyr Glu Asp 
    210                 215                 220                 


Cys Ile Glu Lys Ala Val Gln Phe Phe Val Gln Ala Leu Arg Met Ala 
225                 230                 235                 240 


Pro Asp His Glu Lys Ala Cys Ile Ala Cys Arg Asn Ala Lys Ala Leu 
                245                 250                 255     


Lys Ala Lys Lys Glu Asp Gly Asn Lys Ala Phe Lys Glu Gly Asn Tyr 
            260                 265                 270         


Lys Leu Ala Tyr Glu Leu Tyr Thr Glu Ala Leu Gly Ile Asp Pro Asn 
        275                 280                 285             


Asn Ile Lys Thr Asn Ala Lys Leu Tyr Cys Asn Arg Gly Thr Val Asn 
    290                 295                 300                 


Ser Lys Leu Arg Lys Leu Asp Asp Ala Ile Glu Asp Cys Thr Asn Ala 
305                 310                 315                 320 


Val Lys Leu Asp Asp Thr Tyr Ile Lys Ala Tyr Leu Arg Arg Ala Gln 
                325                 330                 335     


Cys Tyr Met Asp Thr Glu Gln Tyr Glu Glu Ala Val Arg Asp Tyr Glu 
            340                 345                 350         


Lys Val Tyr Gln Thr Glu Lys Thr Lys Glu His Lys Gln Leu Leu Lys 
        355                 360                 365             


Asn Ala Gln Leu Glu Leu Lys Lys Ser Lys Arg Lys Asp Tyr Tyr Lys 
    370                 375                 380                 


Ile Leu Gly Val Asp Lys Asn Ala Ser Glu Asp Glu Ile Lys Lys Ala 
385                 390                 395                 400 


Tyr Arg Lys Arg Ala Leu Met His His Pro Asp Arg His Ser Gly Ala 
                405                 410                 415     


Ser Ala Glu Val Gln Lys Glu Glu Glu Lys Lys Phe Lys Glu Val Gly 
            420                 425                 430         


Glu Ala Phe Thr Ile Leu Ser Asp Pro Lys Lys Lys Thr Arg Tyr Asp 
        435                 440                 445             


Ser Gly Gln Asp Leu Asp Glu Glu Gly Met Asn Met Gly Asp Phe Asp 
    450                 455                 460                 


Pro Asn Asn Ile Phe Lys Ala Phe Phe Gly Gly Pro Gly Gly Phe Ser 
465                 470                 475                 480 


Phe Glu Ala Ser Gly Pro Gly Asn Phe Phe Phe Gln Phe Gly 
                485                 490                 


<210> 8177
<211> 442
<212> PRT
<213> Homo sapiens

<400> 8177
Asn Glu Val Tyr Asn Leu Thr Gln Glu Phe Phe Arg His Asp Lys Pro 
1               5                   10                  15      


Val Asn Ala Glu Ser Gln Asn Ser Val Gly Val Phe Thr Arg Glu Glu 
            20                  25                  30          


Val Arg Asn Arg Ile Arg Asn Asp Pro Asp Asp Pro Glu Ala Thr Lys 
        35                  40                  45              


Arg Leu Lys Leu Ala Met Ile Gln Gln Tyr Leu Lys Val Glu Ser Cys 
    50                  55                  60                  


Glu Ser Ser Ser His Ser Met Asp Glu Val Ser Leu Ser Ala Phe Gly 
65                  70                  75                  80  


Glu Trp Thr Glu Ile Pro Gly Ala His His Ile Ile Pro Ser Gly Phe 
                85                  90                  95      


Met Arg Val Val Glu Leu Leu Ala Glu Gly Ile Pro Ala His Val Ile 
            100                 105                 110         


Gln Leu Gly Lys Pro Val Arg Cys Ile His Trp Asp Gln Ala Ser Ala 
        115                 120                 125             


Arg Pro Arg Gly Pro Glu Ile Glu Pro Arg Gly Glu Gly Asp His Asn 
    130                 135                 140                 


His Asp Thr Gly Glu Gly Gly Gln Gly Gly Glu Glu Pro Arg Gly Gly 
145                 150                 155                 160 


Arg Trp Asp Glu Asp Glu Gln Trp Ser Val Val Val Glu Cys Glu Asp 
                165                 170                 175     


Cys Glu Leu Ile Pro Ala Asp His Val Ile Val Thr Val Ser Leu Gly 
            180                 185                 190         


Val Leu Lys Arg Gln Tyr Thr Ser Phe Phe Arg Pro Gly Leu Pro Thr 
        195                 200                 205             


Glu Lys Val Ala Ala Ile His Arg Leu Gly Ile Gly Thr Thr Asp Lys 
    210                 215                 220                 


Ile Phe Leu Glu Phe Glu Glu Pro Phe Trp Gly Pro Glu Cys Asn Ser 
225                 230                 235                 240 


Leu Gln Phe Val Trp Glu Asp Glu Ala Glu Ser His Thr Leu Thr Tyr 
                245                 250                 255     


Pro Pro Glu Leu Trp Tyr Arg Lys Ile Cys Gly Phe Asp Val Leu Tyr 
            260                 265                 270         


Pro Pro Glu Arg Tyr Gly His Val Leu Ser Gly Trp Ile Cys Gly Glu 
        275                 280                 285             


Glu Ala Leu Val Met Glu Lys Cys Asp Asp Glu Ala Val Ala Glu Ile 
    290                 295                 300                 


Cys Thr Glu Met Leu Arg Gln Phe Thr Gly Asn Pro Asn Ile Pro Lys 
305                 310                 315                 320 


Pro Arg Arg Ile Leu Arg Ser Ala Trp Gly Ser Asn Pro Tyr Phe Arg 
                325                 330                 335     


Gly Ser Tyr Ser Tyr Thr Gln Val Gly Ser Ser Gly Ala Asp Val Glu 
            340                 345                 350         


Lys Leu Ala Lys Pro Leu Pro Tyr Thr Glu Ser Ser Lys Thr Ala His 
        355                 360                 365             


Gly Ser Ser Thr Lys Gln Gln Pro Gly His Leu Phe Ser Ser Lys Cys 
    370                 375                 380                 


Pro Glu Gln Pro Leu Asp Ala Asn Arg Gly Ala Val Lys Pro Met Gln 
385                 390                 395                 400 


Val Leu Phe Ser Gly Glu Ala Thr His Arg Lys Tyr Tyr Ser Thr Thr 
                405                 410                 415     


His Gly Ala Leu Leu Ser Gly Gln Arg Glu Ala Ala Arg Leu Ile Glu 
            420                 425                 430         


Met Tyr Arg Asp Leu Phe Gln Gln Gly Thr 
        435                 440         


<210> 8178
<211> 59
<212> PRT
<213> Homo sapiens

<400> 8178
Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu 
    50                  55                  


<210> 8179
<211> 278
<212> PRT
<213> Homo sapiens

<400> 8179
Met Lys Cys Glu His Cys Thr Arg Lys Glu Cys Ser Lys Lys Thr Lys 
1               5                   10                  15      


Thr Asp Asp Gln Glu Asn Val Ser Ala Asp Ala Pro Ser Pro Ala Gln 
            20                  25                  30          


Glu Asn Gly Glu Lys Gly Glu Phe His Lys Leu Ala Asp Ala Lys Ile 
        35                  40                  45              


Phe Leu Ser Asp Cys Leu Ala Cys Asp Ser Cys Met Thr Ala Glu Glu 
    50                  55                  60                  


Gly Val Gln Leu Ser Gln Gln Asn Ala Lys Asp Phe Phe Arg Val Leu 
65                  70                  75                  80  


Asn Leu Asn Lys Lys Cys Asp Thr Ser Lys His Lys Val Leu Val Val 
                85                  90                  95      


Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala Ala Lys Phe Asn Leu 
            100                 105                 110         


Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly Phe Leu Lys Ser Leu 
        115                 120                 125             


Gly Trp Val Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile Thr Ala 
    130                 135                 140                 


His Leu Cys Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys Ile Phe 
                165                 170                 175     


His Val Ile Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala Leu Gln 
            180                 185                 190         


Glu Ser Leu Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp Cys Val 
        195                 200                 205             


Leu Thr Ser Gly Thr Gly Ser Leu Trp Glu Cys Thr Pro Val Ile Thr 
    210                 215                 220                 


Ala Thr Gln Glu Ala Ala Ala Arg Glu Ser Leu Glu Pro Gly Arg Gln 
225                 230                 235                 240 


Arg Leu Gln Arg Asp Lys Ile Ala Pro Leu Asp Ser Ser Leu Gly Gly 
                245                 250                 255     


Gly Gly Glu Ile Ala Gln Ile Met Glu Gln Gly Asp Leu Ser Val Arg 
            260                 265                 270         


Asp Ala Ala Val Asp Thr 
        275             


<210> 8180
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8180
Xaa Gly Lys Ala Gln Arg Lys Ile Ser Ala Ile His Ile Leu Asp Val 
1               5                   10                  15      


Leu Val Leu Asn Gly Thr Asp Val Arg Glu Gln His Phe Asn Gln Arg 
            20                  25                  30          


Ile Gln Leu Ala Glu Lys Phe Val Lys Ala Val Ser Lys Pro Ser Arg 
        35                  40                  45              


Pro Asp Met Asn Pro Ile Arg Val Lys Glu Val Tyr Arg Leu Glu Glu 
    50                  55                  60                  


Met Glu Lys Ile Phe Val Arg Leu Glu Met Lys Ile Ile Lys Gly Ser 
65                  70                  75                  80  


Ser Gly Thr Pro Lys Leu Ser Tyr Thr Gly Arg Asp Asp Arg His Phe 
                85                  90                  95      


Val Pro Met Gly Leu Tyr Ile Val Arg Thr Val Asn Glu Pro Trp Thr 
            100                 105                 110         


Met Gly Phe Ser Lys Ser Phe Lys Lys Lys Phe Phe Tyr Asn Lys Lys 
        115                 120                 125             


Thr Lys Asp Ser Thr Phe Asp Leu Pro Ala Asp Ser Ile Ala Pro Phe 
    130                 135                 140                 


His Leu Pro Ser Leu Ala Cys Leu Ser Lys Met Asp 
145                 150                 155     


<210> 8181
<211> 399
<212> PRT
<213> Homo sapiens

<400> 8181
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


Leu Asn Cys Val Met Lys Lys His Lys Glu Leu Ser Ser Leu Gln Lys 
        115                 120                 125             


Ile Pro Ser Gln Gln Arg Lys Lys Ile Ser Ser Gly Lys Ser Glu Pro 
    130                 135                 140                 


Pro Leu Gly Asn Glu Lys Ile Ser Ala Glu Ala Val Gly Val Asp Ile 
145                 150                 155                 160 


Ser Gly Arg Phe Met Thr Ser Gly Lys Lys Lys Ala Val Val Ile Arg 
                165                 170                 175     


His Leu Tyr Asn Glu Asp Asn Val Asp Ile Ser Glu Asp Thr Leu Ser 
            180                 185                 190         


Pro Ile Thr Asp Val Asn Glu Ala Val Asp Val Ser Asp Leu Asn Ala 
        195                 200                 205             


Thr Glu Ile Lys Met Pro Glu Val Lys Val Pro Glu Ile Lys Ala Glu 
    210                 215                 220                 


Gln Gln Asp Val Asn Val Asn Pro Glu Ile Thr Ala Leu Gln Thr Met 
225                 230                 235                 240 


Leu Ala Glu Cys Gln Glu Asn Leu Lys Lys Leu Thr Ser Ile Glu Lys 
                245                 250                 255     


Arg Leu Asp Cys Leu Glu Gln Lys Met Lys Gly Lys Val Met Val Asp 
            260                 265                 270         


Glu Asn Thr Trp Thr Asn Leu Leu Ser Arg Val Thr Leu Leu Glu Thr 
        275                 280                 285             


Glu Met Leu Leu Ser Lys Lys Asn Asp Glu Phe Ile Glu Phe Asn Glu 
    290                 295                 300                 


Val Ser Glu Asp Tyr Ala Ser Cys Ser Asp Met Asp Leu Leu Asn Pro 
305                 310                 315                 320 


His Arg Lys Ser Glu Val Glu Arg Pro Ala Ser Ile Pro Leu Ser Ser 
                325                 330                 335     


Gly Tyr Ser Thr Ala Ser Ser Asp Ser Thr Pro Arg Ala Ser Thr Val 
            340                 345                 350         


Asn Tyr Cys Gly Leu Asn Glu Ile Ser Glu Asn Phe Pro Ala Trp Ser 
        355                 360                 365             


Ala Thr Ser Ser Cys Ser Ser Leu Ser Trp Leu Leu Arg Gly His Thr 
    370                 375                 380                 


Ser Tyr Leu Ser Ser Gln Ser Phe Ala Trp Pro Leu Ser Cys Val 
385                 390                 395                 


<210> 8182
<211> 272
<212> PRT
<213> Homo sapiens

<400> 8182
Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr Asp Gln Asp Leu Leu 
1               5                   10                  15      


Leu Met Gln Glu Gly Met Pro Met Arg Lys Val Arg Ser Lys Ser Trp 
            20                  25                  30          


Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp Gly Met Thr Val Trp 
        35                  40                  45              


His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro Ser Phe Ser Ile Ser 
    50                  55                  60                  


Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser Glu Leu Leu Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe Thr Ile Val Phe His 
                85                  90                  95      


Gly Arg Arg Ser Asn Leu Asp Leu Met Ala Asn Ser Val Glu Glu Ala 
            100                 105                 110         


Gln Ile Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser 
        115                 120                 125             


Met Asp His Gln Glu Arg Leu Asp Arg Trp Leu Ser Asp Trp Phe Gln 
    130                 135                 140                 


Arg Gly Asp Lys Asn Gln Asp Gly Lys Met Ser Phe Gln Glu Val Gln 
145                 150                 155                 160 


Arg Leu Leu His Leu Met Asn Val Glu Met Asp Gln Glu Tyr Ala Phe 
                165                 170                 175     


Ser Leu Phe Gln Ala Ala Asp Thr Ser Gln Ser Gly Thr Leu Glu Gly 
            180                 185                 190         


Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Ala Glu Val 
        195                 200                 205             


Gln Glu Leu Phe Glu Ser Phe Ser Ala Asp Gly Gln Lys Leu Thr Leu 
    210                 215                 220                 


Leu Glu Phe Leu Asp Phe Leu Gln Glu Glu Gln Lys Glu Arg Asp Cys 
225                 230                 235                 240 


Thr Ser Glu Leu Ala Leu Glu Leu Ile Asp Arg Tyr Glu Pro Ser Asp 
                245                 250                 255     


Ser Gly Ala Ser Glu Glu Asp Pro Gly Glu Gly Glu Glu Val Asn Thr 
            260                 265                 270         


<210> 8183
<211> 119
<212> PRT
<213> Homo sapiens

<400> 8183
Met Asp Lys Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe 
1               5                   10                  15      


Arg Gln Ala Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln 
            20                  25                  30          


Lys Thr Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu 
        35                  40                  45              


Ser Leu Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu 
    50                  55                  60                  


Val Asn Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu 
65                  70                  75                  80  


Asp Ser Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp 
                85                  90                  95      


Lys Val Ile Ser Gly Ile Ala Arg Glu Lys Leu Pro Lys Val Asp Ile 
            100                 105                 110         


Ala Ser Ala Glu Ser Ser Ile 
        115                 


<210> 8184
<211> 626
<212> PRT
<213> Homo sapiens

<400> 8184
Met Cys Ser Thr Leu Lys Lys Cys Gly Thr Tyr Arg Thr Glu Val Ala 
1               5                   10                  15      


Glu Cys His Asp His Gly Ser Thr Phe Gln Gly Arg Lys Lys Gly Gly 
            20                  25                  30          


Ser Ser Phe Arg Asp Asn Phe Asp Lys Arg Ser Cys His Tyr Glu His 
        35                  40                  45              


Gly Gly Tyr Glu Arg Pro Pro Ser His Cys Gln Glu Asn Asp Gly Ser 
    50                  55                  60                  


Val Glu Met Arg Asp Val His Lys Asp Gln Gln Leu Arg His Thr Pro 
65                  70                  75                  80  


Tyr Ser Ile Arg Cys Glu Arg Arg Met Lys Trp His Ser Glu Asp Glu 
                85                  90                  95      


Ile Arg Ile Thr Thr Trp Arg Asn Arg Lys Pro Pro Glu Arg Lys Met 
            100                 105                 110         


Ser Gln Asn Thr Gln Asp Gly Tyr Thr Arg Asn Trp Phe Lys Val Thr 
        115                 120                 125             


Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser Ile 
    130                 135                 140                 


Gln Ser His Cys Ser Asp Arg Phe Thr Pro Val Asp Phe His Tyr Val 
145                 150                 155                 160 


Arg Asn Arg Ala Cys Phe Phe Val Gln Asp Ala Ser Ala Ala Ser Ala 
                165                 170                 175     


Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys Ile 
            180                 185                 190         


Cys Ile Phe Val Asn His Ser Thr Ala Pro Tyr Ser Val Lys Asn Lys 
        195                 200                 205             


Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys Arg 
    210                 215                 220                 


Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe Asp 
225                 230                 235                 240 


Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg Asn 
                245                 250                 255     


Cys Met Ala Ala Thr Leu Lys Ile Ile Glu Arg Asn Phe Pro Glu Leu 
            260                 265                 270         


Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp Gly Leu 
        275                 280                 285             


Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn Leu Ser 
    290                 295                 300                 


Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys Gly Leu 
305                 310                 315                 320 


Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser Thr Phe 
                325                 330                 335     


Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe Pro Lys 
            340                 345                 350         


Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile Val Asp 
        355                 360                 365             


Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe Thr Gly 
    370                 375                 380                 


Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln Tyr Tyr 
385                 390                 395                 400 


Ser Ile Tyr Asp Ser Gly Asp Arg Gln Gly Leu Leu Gly Ala Tyr His 
                405                 410                 415     


Asp Glu Ala Cys Phe Ser Leu Ala Ile Pro Phe Asp Pro Lys Asp Ser 
            420                 425                 430         


Ala Pro Ser Ser Leu Cys Lys Tyr Phe Glu Asp Ser Arg Asn Met Lys 
        435                 440                 445             


Thr Leu Lys Asp Pro Tyr Leu Lys Gly Glu Leu Leu Arg Arg Thr Lys 
    450                 455                 460                 


Arg Asp Ile Val Asp Ser Leu Ser Ala Leu Pro Lys Thr Gln His Asp 
465                 470                 475                 480 


Leu Ser Ser Ile Leu Val Asp Val Trp Cys Gln Thr Glu Arg Met Leu 
                485                 490                 495     


Cys Phe Ser Val Asn Gly Val Phe Lys Glu Val Glu Gly Gln Ser Gln 
            500                 505                 510         


Gly Ser Val Leu Ala Phe Thr Arg Thr Phe Ile Ala Thr Pro Gly Ser 
        515                 520                 525             


Ser Ser Ser Leu Cys Ile Val Asn Asp Glu Leu Phe Val Arg Asp Ala 
    530                 535                 540                 


Ser Pro Gln Glu Thr Gln Ser Ala Phe Ser Ile Pro Val Ser Thr Leu 
545                 550                 555                 560 


Ser Ser Ser Ser Glu Pro Ser Leu Ser Gln Glu Gln Gln Glu Met Val 
                565                 570                 575     


Gln Ala Phe Ser Ala Gln Ser Gly Met Lys Leu Glu Trp Ser Gln Lys 
            580                 585                 590         


Cys Leu Gln Asp Asn Glu Trp Asn Tyr Thr Arg Ala Gly Gln Ala Phe 
        595                 600                 605             


Thr Met Leu Gln Thr Glu Gly Lys Ile Pro Ala Glu Ala Phe Lys Gln 
    610                 615                 620                 


Ile Ser 
625     


<210> 8185
<211> 62
<212> PRT
<213> Homo sapiens

<400> 8185
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser 
    50                  55                  60          


<210> 8186
<211> 75
<212> PRT
<213> Homo sapiens

<400> 8186
Met Arg Leu Ser Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ile Pro Gly Gly Leu Gly Asp Arg Ala Pro Leu Thr Ala Thr Ala Pro 
            20                  25                  30          


Gln Leu Asp Asp Glu Glu Met Tyr Ser Ala His Met Pro Ala His Leu 
        35                  40                  45              


Arg Cys Asp Ala Cys Arg Ala Val Ala Tyr Gln Arg Leu Cys Ser Tyr 
    50                  55                  60                  


Pro Pro His Leu Pro Leu Thr Glu Gln Gln Ser 
65                  70                  75  


<210> 8187
<211> 872
<212> PRT
<213> Homo sapiens

<400> 8187
Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe 
1               5                   10                  15      


Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg 
            20                  25                  30          


Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu 
        35                  40                  45              


Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu 
    50                  55                  60                  


Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met 
65                  70                  75                  80  


Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr 
                85                  90                  95      


Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro 
            100                 105                 110         


Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu 
        115                 120                 125             


Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val 
    130                 135                 140                 


Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp 
145                 150                 155                 160 


Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys 
                165                 170                 175     


Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys 
            180                 185                 190         


Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys 
        195                 200                 205             


Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe 
    210                 215                 220                 


Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile 
225                 230                 235                 240 


Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys 
                245                 250                 255     


Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu 
            260                 265                 270         


Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu 
        275                 280                 285             


Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp 
    290                 295                 300                 


Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser 
305                 310                 315                 320 


Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu 
                325                 330                 335     


Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg 
            340                 345                 350         


Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser 
        355                 360                 365             


Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu 
    370                 375                 380                 


Glu Ala Glu Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu 
385                 390                 395                 400 


Trp Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro 
                405                 410                 415     


Leu His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile 
            420                 425                 430         


Ser Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met 
        435                 440                 445             


Arg Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg 
    450                 455                 460                 


Gly Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp 
465                 470                 475                 480 


Asn Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val 
                485                 490                 495     


Asn Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln 
            500                 505                 510         


His Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile 
        515                 520                 525             


His Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr 
    530                 535                 540                 


Pro Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn 
545                 550                 555                 560 


Ile Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu 
                565                 570                 575     


Leu Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly 
            580                 585                 590         


Asn Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val 
        595                 600                 605             


Leu Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr 
    610                 615                 620                 


Tyr Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys 
625                 630                 635                 640 


Gly Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His 
                645                 650                 655     


Gly Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro 
            660                 665                 670         


Leu Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met 
        675                 680                 685             


Gly Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn 
    690                 695                 700                 


Thr Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys 
705                 710                 715                 720 


Lys Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His 
                725                 730                 735     


Ala Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn 
            740                 745                 750         


Phe Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala 
        755                 760                 765             


Gln Pro Pro Gly Pro Ala Gln Ser Leu Thr Pro Gly Leu Pro Tyr Pro 
    770                 775                 780                 


His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln Pro Arg Pro Pro 
785                 790                 795                 800 


Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val Pro Thr Gly 
                805                 810                 815     


Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg Gly Asn Tyr 
            820                 825                 830         


Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys Pro Arg Asn Arg 
        835                 840                 845             


Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr Arg Asp Leu Asp 
    850                 855                 860                 


Ala Pro Asp Asp Val Asp Phe Phe 
865                 870         


<210> 8188
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8188
Xaa Pro Glu Asp Val Gln Ala Leu Val Ser Gly Lys Leu Ala Leu Arg 
1               5                   10                  15      


Tyr Ala Gly Arg Gln Thr Glu Ala Leu Lys Cys Val Ala Gln Ala Ser 
            20                  25                  30          


Lys Asn Arg Ser Leu Ala Asp Phe Glu Lys Ala Leu Thr Asp Tyr Arg 
        35                  40                  45              


Ala Glu Leu Arg Asp Asp Pro Ile Ile Ser Thr His Leu Ala Lys Leu 
    50                  55                  60                  


Tyr Asp Asn Leu Leu Glu Gln Asn Leu Ile Arg Val Ile Glu Pro Phe 
65                  70                  75                  80  


Ser Arg Val Gln Ile Glu His Ile Ser Ser Leu Ile Lys Leu Ser Lys 
                85                  90                  95      


Ala Asp Val Glu Arg Lys Leu Ser Gln Met Ile Leu Asp Lys Lys Phe 
            100                 105                 110         


His Gly Ile Leu Asp Gln Gly Glu Gly Val Leu Ile Ile Phe Asp Glu 
        115                 120                 125             


Pro Pro Val Asp Lys Thr Tyr Glu Ala Ala Leu Glu Thr Ile Gln Asn 
    130                 135                 140                 


Met Ser Lys Val Val Asp Ser Leu Tyr Asn Lys Ala Lys Lys Leu Thr 
145                 150                 155                 160 


<210> 8189
<211> 1301
<212> PRT
<213> Homo sapiens

<400> 8189
Met Trp Arg Arg Lys His Pro Arg Thr Ser Gly Gly Thr Arg Gly Val 
1               5                   10                  15      


Leu Ser Gly Asn Arg Gly Val Glu Tyr Gly Ser Gly Arg Gly His Leu 
            20                  25                  30          


Gly Thr Phe Glu Gly Arg Trp Arg Lys Leu Pro Lys Met Pro Glu Ala 
        35                  40                  45              


Val Gly Thr Asp Pro Ser Thr Ser Arg Lys Met Ala Glu Leu Glu Glu 
    50                  55                  60                  


Val Thr Leu Asp Gly Lys Pro Leu Gln Ala Leu Arg Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Ala Leu Glu Gln Arg Gly Leu Ala Lys Ser Gly Gln Lys Ser 
                85                  90                  95      


Ala Leu Val Lys Arg Leu Lys Gly Ala Leu Met Leu Glu Asn Leu Gln 
            100                 105                 110         


Lys His Ser Thr Pro His Ala Ala Phe Gln Pro Asn Ser Gln Ile Gly 
        115                 120                 125             


Glu Glu Met Ser Gln Asn Ser Phe Ile Lys Gln Tyr Leu Glu Lys Gln 
    130                 135                 140                 


Gln Glu Leu Leu Arg Gln Arg Leu Glu Arg Glu Ala Arg Glu Ala Ala 
145                 150                 155                 160 


Glu Leu Glu Gly Lys Ser Ser Ser Ile Ser Glu Glu Lys Gly Asp Ser 
                165                 170                 175     


Asp Asp Glu Lys Pro Arg Lys Gly Glu Arg Arg Ser Ser Arg Val Arg 
            180                 185                 190         


Gln Ala Arg Ala Ala Lys Leu Ser Glu Gly Ser Gln Pro Ala Glu Glu 
        195                 200                 205             


Glu Glu Asp Gln Glu Thr Pro Ser Arg Asn Leu Arg Val Arg Ala Asp 
    210                 215                 220                 


Arg Asn Leu Lys Thr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Glu Asp Asp Glu Glu Glu Glu Gly Asp Asp Glu Gly Gln Lys Ser Arg 
                245                 250                 255     


Glu Ala Pro Ile Leu Lys Glu Phe Lys Glu Glu Gly Glu Glu Ile Pro 
            260                 265                 270         


Arg Val Lys Pro Glu Glu Met Met Asp Glu Arg Pro Lys Thr Arg Ser 
        275                 280                 285             


Gln Glu Gln Glu Val Leu Glu Arg Gly Gly Arg Phe Thr Arg Ser Gln 
    290                 295                 300                 


Glu Glu Ala Arg Lys Ser His Leu Ala Arg Gln Gln Gln Glu Lys Glu 
305                 310                 315                 320 


Met Lys Thr Thr Ser Pro Leu Glu Glu Glu Glu Arg Glu Ile Lys Ser 
                325                 330                 335     


Ser Gln Gly Leu Lys Glu Lys Ser Lys Ser Pro Ser Pro Pro Arg Leu 
            340                 345                 350         


Thr Glu Asp Arg Lys Lys Ala Ser Leu Val Ala Leu Pro Glu Gln Thr 
        355                 360                 365             


Ala Ser Glu Glu Glu Thr Pro Pro Pro Leu Leu Thr Lys Glu Ala Ser 
    370                 375                 380                 


Ser Pro Pro Pro His Pro Gln Leu His Ser Glu Glu Glu Ile Glu Pro 
385                 390                 395                 400 


Met Glu Gly Pro Ala Pro Ala Val Leu Ile Gln Leu Ser Pro Pro Asn 
                405                 410                 415     


Thr Asp Ala Asp Thr Arg Glu Leu Leu Val Ser Gln His Thr Val Gln 
            420                 425                 430         


Leu Val Gly Gly Leu Ser Pro Leu Ser Ser Pro Ser Asp Thr Lys Ala 
        435                 440                 445             


Glu Ser Pro Ala Glu Lys Val Pro Glu Glu Ser Val Leu Pro Leu Val 
    450                 455                 460                 


Gln Lys Ser Thr Leu Ala Asp Tyr Ser Ala Gln Lys Asp Leu Glu Pro 
465                 470                 475                 480 


Glu Ser Asp Arg Ser Ala Gln Pro Leu Pro Leu Lys Ile Glu Glu Leu 
                485                 490                 495     


Ala Leu Ala Lys Gly Ile Thr Glu Glu Cys Leu Lys Gln Pro Ser Leu 
            500                 505                 510         


Glu Gln Lys Glu Gly Arg Arg Ala Ser His Thr Leu Leu Pro Ser His 
        515                 520                 525             


Arg Leu Lys Gln Ser Ala Asp Ser Ser Ser Ser Arg Ser Ser Ser Ser 
    530                 535                 540                 


Ser Ser Ser Ser Ser Arg Ser Arg Ser Arg Ser Pro Asp Ser Ser Gly 
545                 550                 555                 560 


Ser Arg Ser His Ser Pro Leu Arg Ser Lys Gln Arg Asp Val Ala Gln 
                565                 570                 575     


Ala Arg Thr His Ala Asn Pro Arg Gly Arg Pro Lys Met Gly Ser Arg 
            580                 585                 590         


Ser Thr Ser Glu Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Ala 
        595                 600                 605             


Ser Ser Asn Ser Arg Lys Ser Leu Ser Pro Gly Val Ser Arg Asp Ser 
    610                 615                 620                 


Ser Thr Ser Tyr Thr Glu Thr Lys Asp Pro Ser Ser Gly Gln Glu Val 
625                 630                 635                 640 


Ala Thr Pro Pro Val Pro Gln Leu Gln Val Cys Glu Pro Lys Glu Arg 
                645                 650                 655     


Thr Ser Thr Ser Ser Ser Ser Val Gln Ala Arg Arg Leu Ser Gln Pro 
            660                 665                 670         


Glu Ser Ala Glu Lys His Val Thr Gln Arg Leu Gln Pro Glu Arg Gly 
        675                 680                 685             


Ser Pro Lys Lys Cys Glu Ala Glu Glu Ala Glu Pro Pro Ala Ala Thr 
    690                 695                 700                 


Gln Pro Gln Thr Ser Glu Thr Gln Thr Ser His Leu Pro Glu Ser Glu 
705                 710                 715                 720 


Arg Ile His His Thr Val Glu Glu Lys Glu Glu Val Thr Met Asp Thr 
                725                 730                 735     


Ser Glu Asn Arg Pro Glu Asn Asp Val Pro Glu Pro Pro Met Pro Ile 
            740                 745                 750         


Ala Asp Gln Val Ser Asn Asp Asp Arg Pro Glu Gly Ser Val Glu Asp 
        755                 760                 765             


Glu Glu Lys Lys Glu Ser Ser Leu Pro Lys Ser Phe Lys Arg Lys Ile 
    770                 775                 780                 


Ser Val Val Ser Ala Thr Lys Gly Val Pro Ala Gly Asn Ser Asp Thr 
785                 790                 795                 800 


Glu Gly Gly Gln Pro Gly Arg Lys Arg Arg Trp Gly Ala Ser Thr Ala 
                805                 810                 815     


Thr Thr Gln Lys Lys Pro Ser Ile Ser Ile Thr Thr Glu Ser Leu Lys 
            820                 825                 830         


Ser Leu Ile Pro Asp Ile Lys Pro Leu Ala Gly Gln Glu Ala Val Val 
        835                 840                 845             


Asp Leu His Ala Asp Asp Ser Arg Ile Ser Glu Asp Glu Thr Glu Arg 
    850                 855                 860                 


Asn Gly Asp Asp Gly Thr His Asp Lys Gly Leu Lys Ile Cys Arg Thr 
865                 870                 875                 880 


Val Thr Gln Val Val Pro Ala Glu Gly Gln Glu Asn Gly Gln Arg Glu 
                885                 890                 895     


Glu Glu Glu Glu Glu Lys Glu Pro Glu Ala Glu Pro Pro Val Pro Pro 
            900                 905                 910         


Gln Val Ser Val Glu Val Ala Leu Pro Pro Pro Ala Glu His Glu Val 
        915                 920                 925             


Lys Lys Val Thr Leu Gly Asp Thr Leu Thr Arg Arg Ser Ile Ser Gln 
    930                 935                 940                 


Gln Lys Ser Gly Val Ser Ile Thr Ile Asp Asp Pro Val Arg Thr Ala 
945                 950                 955                 960 


Gln Val Pro Ser Pro Pro Arg Gly Lys Ile Ser Asn Ile Val His Ile 
                965                 970                 975     


Ser Asn Leu Val Arg Pro Phe Thr Leu Gly Gln Leu Lys Glu Leu Leu 
            980                 985                 990         


Gly Arg Thr Gly Thr Leu Val Glu  Glu Ala Phe Trp Ile  Asp Lys Ile 
        995                 1000                 1005             


Lys Ser  His Cys Phe Val Thr  Tyr Ser Thr Val Glu  Glu Ala Val 
    1010                 1015                 1020             


Ala Thr  Arg Thr Ala Leu His  Gly Val Lys Trp Pro  Gln Ser Asn 
    1025                 1030                 1035             


Pro Lys  Phe Leu Cys Ala Asp  Tyr Ala Glu Gln Asp  Glu Leu Asp 
    1040                 1045                 1050             


Tyr His  Arg Gly Leu Leu Val  Asp Arg Pro Ser Glu  Thr Lys Thr 
    1055                 1060                 1065             


Glu Glu  Gln Gly Ile Pro Arg  Pro Leu His Pro Pro  Pro Pro Pro 
    1070                 1075                 1080             


Pro Val  Gln Pro Pro Gln His  Pro Arg Ala Glu Gln  Arg Glu Gln 
    1085                 1090                 1095             


Glu Arg  Ala Val Arg Glu Gln  Trp Ala Glu Arg Glu  Arg Glu Met 
    1100                 1105                 1110             


Glu Arg  Arg Glu Arg Thr Arg  Ser Glu Arg Glu Trp  Asp Arg Asp 
    1115                 1120                 1125             


Lys Val  Arg Glu Gly Pro Arg  Ser Arg Ser Arg Ser  Arg Asp Arg 
    1130                 1135                 1140             


Arg Arg  Lys Glu Arg Ala Lys  Ser Lys Glu Lys Lys  Ser Glu Lys 
    1145                 1150                 1155             


Lys Glu  Lys Ala Gln Glu Glu  Pro Pro Ala Lys Leu  Leu Asp Asp 
    1160                 1165                 1170             


Leu Phe  Arg Lys Thr Lys Ala  Ala Pro Cys Ile Tyr  Trp Leu Pro 
    1175                 1180                 1185             


Leu Thr  Asp Ser Gln Ile Val  Gln Lys Glu Ala Glu  Arg Ala Glu 
    1190                 1195                 1200             


Arg Ala  Lys Glu Arg Glu Lys  Arg Arg Lys Glu Gln  Glu Glu Glu 
    1205                 1210                 1215             


Glu Gln  Lys Glu Arg Glu Lys  Glu Ala Glu Arg Glu  Arg Asn Arg 
    1220                 1225                 1230             


Gln Leu  Glu Arg Glu Lys Arg  Arg Glu His Ser Arg  Glu Arg Asp 
    1235                 1240                 1245             


Arg Glu  Arg Glu Arg Glu Arg  Glu Arg Asp Arg Gly  Asp Arg Asp 
    1250                 1255                 1260             


Arg Asp  Arg Glu Arg Asp Arg  Glu Arg Gly Arg Glu  Arg Asp Arg 
    1265                 1270                 1275             


Arg Asp  Thr Lys Arg His Ser  Arg Ser Arg Ser Arg  Ser Thr Pro 
    1280                 1285                 1290             


Val Arg  Asp Arg Gly Gly Arg  Arg 
    1295                 1300     


<210> 8190
<211> 76
<212> PRT
<213> Homo sapiens

<400> 8190
Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn Thr Asn Leu 
1               5                   10                  15      


Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu Leu Ser Cys 
            20                  25                  30          


Leu Phe Gln Ser Glu Lys Ser Leu Glu Thr Lys Ile Ala Lys Trp Asn 
        35                  40                  45              


Leu Gln Ser Arg Met Asn Lys Asn Glu Ala Ile Val Met Lys Glu Ala 
    50                  55                  60                  


Ser Arg Gln Lys Thr Val Ala Leu Lys Lys Ala Ser 
65                  70                  75      


<210> 8191
<211> 582
<212> PRT
<213> Homo sapiens

<400> 8191
Met Glu Val Arg Ala Ser Leu Gln Lys Val Ser Gly Ser Ser Asp Ser 
1               5                   10                  15      


Val Ala Thr Met Asn Ser Glu Glu Phe Val Leu Val Pro Gln Tyr Ala 
            20                  25                  30          


Asp Asp Asn Ser Thr Lys His Glu Glu Lys Pro Gln Leu Lys Ile Val 
        35                  40                  45              


Ser Asn Gly Asp Glu Gln Leu Glu Lys Ala Met Glu Glu Ile Leu Arg 
    50                  55                  60                  


Asp Ser Glu Lys Arg Pro Ser Ser Leu Leu Val Asp Cys Gln Ser Ser 
65                  70                  75                  80  


Ser Glu Ile Ser Asp His Ser Phe Gly Asp Ile Pro Ala Ser Gln Thr 
                85                  90                  95      


Asn Lys Pro Ser Leu Gln Leu Ile Leu Asp Pro Ser Asn Thr Glu Ile 
            100                 105                 110         


Ser Thr Pro Arg Pro Ser Ser Pro Gly Gly Leu Pro Glu Glu Asp Ser 
        115                 120                 125             


Val Leu Phe Asn Lys Leu Thr Tyr Leu Gly Cys Met Lys Val Ser Ser 
    130                 135                 140                 


Pro Arg Asn Glu Val Glu Ala Leu Arg Ala Met Ala Thr Met Lys Ser 
145                 150                 155                 160 


Ser Ser Gln Tyr Pro Phe Pro Val Thr Leu Tyr Val Pro Asn Val Pro 
                165                 170                 175     


Glu Gly Ser Val Arg Ile Ile Asp Gln Ser Ser Asn Val Glu Ile Ala 
            180                 185                 190         


Ser Phe Pro Ile Tyr Lys Val Leu Phe Cys Ala Arg Gly His Asp Gly 
        195                 200                 205             


Thr Thr Glu Ser Asn Cys Phe Ala Phe Thr Glu Ser Ser His Gly Ser 
    210                 215                 220                 


Glu Glu Phe Gln Ile His Val Phe Ser Cys Glu Ile Lys Glu Ala Val 
225                 230                 235                 240 


Ser Arg Ile Leu Tyr Ser Phe Cys Thr Ala Phe Lys Arg Ser Ser Arg 
                245                 250                 255     


Gln Val Ser Asp Val Lys Asp Ser Val Ile Pro Thr Pro Asp Ser Asp 
            260                 265                 270         


Val Phe Thr Phe Ser Val Ser Leu Glu Val Lys Glu Asp Asp Gly Lys 
        275                 280                 285             


Gly Asn Phe Arg Leu Leu Val Ile Pro Ile Pro Phe Glu Tyr Phe Ser 
    290                 295                 300                 


Pro Val Pro Lys Asp Arg Asp Lys Phe Tyr Phe Lys Leu Lys Gln Gly 
305                 310                 315                 320 


Ile Glu Lys Lys Val Val Ile Thr Val Gln Gln Leu Ser Asn Lys Glu 
                325                 330                 335     


Leu Ala Ile Glu Arg Cys Phe Gly Met Leu Leu Ser Pro Gly Arg Asn 
            340                 345                 350         


Val Lys Asn Ser Asp Met His Leu Leu Asp Met Glu Ser Met Gly Lys 
        355                 360                 365             


Ser Tyr Asp Gly Arg Ala Tyr Val Ile Thr Gly Met Trp Asn Pro Asn 
    370                 375                 380                 


Ala Pro Val Phe Leu Ala Leu Asn Glu Glu Thr Pro Lys Asp Lys Gln 
385                 390                 395                 400 


Val Tyr Met Thr Val Ala Val Asp Met Val Val Thr Glu Val Val Glu 
                405                 410                 415     


Pro Val Arg Phe Leu Leu Glu Thr Val Val Arg Val Tyr Pro Ala Asn 
            420                 425                 430         


Glu Arg Phe Trp Tyr Phe Ser Arg Lys Thr Phe Thr Glu Thr Phe Phe 
        435                 440                 445             


Met Arg Leu Lys Gln Ser Glu Gly Lys Gly His Thr Asn Ala Gly Asp 
    450                 455                 460                 


Ala Ile Tyr Glu Val Val Ser Leu Gln Arg Glu Ser Asp Lys Glu Glu 
465                 470                 475                 480 


Pro Val Thr Pro Thr Ser Gly Gly Gly Pro Met Ser Pro Gln Asp Asp 
                485                 490                 495     


Glu Ala Glu Glu Glu Ser Asp Asn Glu Leu Ser Ser Gly Thr Gly Asp 
            500                 505                 510         


Val Ser Lys Asp Cys Pro Glu Lys Ile Leu Tyr Ser Trp Gly Glu Leu 
        515                 520                 525             


Leu Gly Lys Trp His Ser Asn Leu Gly Ala Arg Pro Lys Gly Leu Ser 
    530                 535                 540                 


Thr Leu Val Lys Ser Gly Val Pro Glu Ala Leu Arg Ala Glu Val Trp 
545                 550                 555                 560 


Gln Leu Leu Ala Gly Cys His Asp Asn Gln Ala Met Leu Asp Arg Tyr 
                565                 570                 575     


Arg Ile Leu Ile Thr Lys 
            580         


<210> 8192
<211> 45
<212> PRT
<213> Homo sapiens

<400> 8192
Met Asp Ala Asp Ser Asp Val Ala Leu Asp Ile Leu Ile Thr Asn Val 
1               5                   10                  15      


Val Cys Val Phe Arg Thr Arg Cys His Leu Asn Leu Arg Lys Ile Ala 
            20                  25                  30          


Leu Glu Gly Ala Asn Val Ile Tyr Lys Arg Asp Val Gly 
        35                  40                  45  


<210> 8193
<211> 253
<212> PRT
<213> Homo sapiens

<400> 8193
Met Glu Asp Ala Pro Gln Arg Leu Arg Trp Gln Ala His Leu Glu Phe 
1               5                   10                  15      


Thr His Asn His Asp Val Gly Asp Leu Thr Trp Asp Lys Ile Ala Val 
            20                  25                  30          


Ser Leu Pro Arg Ser Glu Lys Leu Arg Ser Leu Val Leu Ala Gly Ile 
        35                  40                  45              


Pro His Gly Met Arg Pro Gln Leu Trp Met Arg Leu Ser Gly Ala Leu 
    50                  55                  60                  


Gln Lys Lys Arg Asn Ser Glu Leu Ser Tyr Arg Glu Ile Val Lys Asn 
65                  70                  75                  80  


Ser Ser Asn Asp Glu Thr Ile Ala Ala Lys Gln Ile Glu Lys Asp Leu 
                85                  90                  95      


Leu Arg Thr Met Pro Ser Asn Ala Cys Phe Ala Ser Met Gly Ser Ile 
            100                 105                 110         


Gly Val Pro Arg Leu Arg Arg Val Leu Arg Ala Leu Ala Trp Leu Tyr 
        115                 120                 125             


Pro Glu Ile Gly Tyr Cys Gln Gly Thr Gly Met Val Ala Ala Cys Leu 
    130                 135                 140                 


Leu Leu Phe Leu Glu Glu Glu Asp Ala Phe Trp Met Met Ser Ala Ile 
145                 150                 155                 160 


Ile Glu Asp Leu Leu Pro Ala Ser Tyr Phe Ser Thr Thr Leu Leu Gly 
                165                 170                 175     


Val Gln Thr Asp Gln Arg Val Leu Arg His Leu Ile Val Gln Tyr Leu 
            180                 185                 190         


Pro Arg Leu Asp Lys Leu Leu Gln Glu His Asp Ile Glu Leu Ser Leu 
        195                 200                 205             


Ile Thr Leu His Trp Phe Leu Thr Ala Phe Ala Ser Val Val Asp Ile 
    210                 215                 220                 


Lys Leu Leu Leu Arg Ile Trp Asp Leu Phe Phe Tyr Glu Gly Ser Arg 
225                 230                 235                 240 


Val Leu Phe Gln Leu Thr Leu Gly Met Leu His Leu Lys 
                245                 250             


<210> 8194
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8194
Xaa Pro Leu Val Lys Val Gln Ile Phe Gly Val Arg Leu Asp Thr Ala 
1               5                   10                  15      


Arg Gln Glu Thr Asn Tyr Val Glu Asn Asn Gly Phe Asn Pro Tyr Trp 
            20                  25                  30          


Gly Gln Thr Leu Cys Phe Arg Val Leu Val Pro Glu Leu Ala Met Leu 
        35                  40                  45              


Arg Phe Val Val Met Asp Tyr Asp Trp Lys Ser Arg Asn Asp Phe Ile 
    50                  55                  60                  


Gly Gln Tyr Thr Leu Pro Trp Thr Cys Met Gln Gln Gly Tyr Arg His 
65                  70                  75                  80  


Ile His Leu Leu Ser Lys Asp Gly Ile Ser Leu Arg Pro Ala Ser Ile 
                85                  90                  95      


Phe Val Tyr Ile Cys Ile Gln Glu Gly Leu Glu Gly Asp Glu Ser 
            100                 105                 110     


<210> 8195
<211> 183
<212> PRT
<213> Homo sapiens

<400> 8195
Met Met Gln Ile Cys Asp Thr Tyr Asn Gln Lys His Ser Leu Phe Asn 
1               5                   10                  15      


Ala Met Asn Arg Phe Ile Gly Ala Val Asn Asn Met Asp Gln Thr Val 
            20                  25                  30          


Met Val Pro Ser Leu Leu Arg Asp Val Pro Leu Ala Asp Pro Gly Leu 
        35                  40                  45              


Asp Asn Asp Val Gly Val Glu Val Gly Gly Ser Gly Gly Cys Leu Glu 
    50                  55                  60                  


Glu Arg Thr Pro Pro Val Pro Asp Ser Gly Ser Ala Asn Gly Ser Phe 
65                  70                  75                  80  


Phe Ala Pro Ser Arg Asp Met Tyr Ser His Tyr Val Leu Leu Lys Ser 
                85                  90                  95      


Ile Arg Asn Asp Ile Glu Trp Gly Val Leu His Gln Pro Pro Pro Pro 
            100                 105                 110         


Ala Gly Ser Glu Glu Gly Ser Ala Trp Lys Ser Lys Asp Ile Leu Val 
        115                 120                 125             


Asp Leu Gly His Leu Glu Gly Ala Asp Ala Gly Glu Glu Asp Leu Glu 
    130                 135                 140                 


Gln Gln Phe His Tyr His Leu Arg Gly Leu His Thr Val Leu Ser Lys 
145                 150                 155                 160 


Leu Thr Arg Lys Ala Asn Ile Leu Thr Asn Arg Tyr Lys Gln Glu Ile 
                165                 170                 175     


Gly Phe Gly Asn Trp Gly His 
            180             


<210> 8196
<211> 404
<212> PRT
<213> Homo sapiens

<400> 8196
Met Met Leu Ser Thr Glu Gly Arg Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Met Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Thr Ser Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Glu Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Ser Val Glu Met Asp Trp Met 
                85                  90                  95      


Thr Leu Pro Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val 
            100                 105                 110         


Gln Phe Ala Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys 
        115                 120                 125             


Glu Arg Ile Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala 
    130                 135                 140                 


Glu Val Arg Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln 
145                 150                 155                 160 


Arg Pro Gly Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser 
                165                 170                 175     


Ile Gly Arg Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly 
            180                 185                 190         


Gly Gly Tyr Gly Gly Tyr Asp Asp Tyr Gly Gly Tyr Asn Asp Gly Tyr 
        195                 200                 205             


Gly Phe Gly Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser 
    210                 215                 220                 


Gly Met Ser Asp His Arg Tyr Gly Asp Gly Gly Ser Ser Phe Gln Ser 
225                 230                 235                 240 


Thr Thr Gly His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr 
                245                 250                 255     


Glu Asn Asp Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Met Arg Val 
            260                 265                 270         


His Ile Glu Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val 
        275                 280                 285             


Glu Phe Ala Thr His Glu Asp Ala Val Ala Ala Met Ala Lys Asp Lys 
    290                 295                 300                 


Ala Asn Met Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala 
305                 310                 315                 320 


Gly Thr Ser Gly Gly Ala Tyr Asp His Ser Tyr Val Glu Leu Phe Leu 
                325                 330                 335     


Asn Ser Thr Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met 
            340                 345                 350         


Gly Gly Met Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser 
        355                 360                 365             


Gln Gln Leu Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser 
    370                 375                 380                 


Met Ser Gly Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Tyr Gln 
385                 390                 395                 400 


Ser Asn Leu Ala 
                


<210> 8197
<211> 514
<212> PRT
<213> Homo sapiens

<400> 8197
Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu 
1               5                   10                  15      


Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser 
            20                  25                  30          


His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val Pro Pro Ala Ala 
        35                  40                  45              


Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Val 
    50                  55                  60                  


Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg Pro Ile Glu Ser 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln Thr Arg Gln 
                85                  90                  95      


Gln Ala Tyr Arg Asp Lys Leu Ala Gln Gln Gln Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ser Gln Gln Gly Ser Ala Lys Asn Gly Glu 
        115                 120                 125             


Asn Thr Ala Asn Gly Glu Glu Asn Gly Ala His Thr Ile Ala Asn Asn 
    130                 135                 140                 


His Thr Asp Met Met Glu Val Asp Gly Asp Val Glu Ile Pro Pro Asn 
145                 150                 155                 160 


Lys Ala Val Val Leu Arg Gly His Glu Ser Glu Val Phe Ile Cys Ala 
                165                 170                 175     


Trp Asn Pro Val Ser Asp Leu Leu Ala Ser Gly Ser Gly Asp Ser Thr 
            180                 185                 190         


Ala Arg Ile Trp Asn Leu Ser Glu Asn Ser Thr Ser Gly Ser Thr Gln 
        195                 200                 205             


Leu Val Leu Arg His Cys Ile Arg Glu Gly Gly Gln Asp Val Pro Ser 
    210                 215                 220                 


Asn Lys Asp Val Thr Ser Leu Asp Trp Asn Ser Glu Gly Thr Leu Leu 
225                 230                 235                 240 


Ala Thr Gly Ser Tyr Asp Gly Phe Ala Arg Ile Trp Thr Lys Asp Gly 
                245                 250                 255     


Asn Leu Ala Ser Thr Leu Gly Gln His Lys Gly Pro Ile Phe Ala Leu 
            260                 265                 270         


Lys Trp Asn Lys Lys Gly Asn Phe Ile Leu Ser Ala Gly Val Asp Lys 
        275                 280                 285             


Thr Thr Ile Ile Trp Asp Ala His Thr Gly Glu Ala Lys Gln Gln Phe 
    290                 295                 300                 


Pro Phe His Ser Ala Pro Ala Leu Asp Val Asp Trp Gln Ser Asn Asn 
305                 310                 315                 320 


Thr Phe Ala Ser Cys Ser Thr Asp Met Cys Ile His Val Cys Lys Leu 
                325                 330                 335     


Gly Gln Asp Arg Pro Ile Lys Thr Phe Gln Gly His Thr Asn Glu Val 
            340                 345                 350         


Asn Ala Ile Lys Trp Asp Pro Thr Gly Asn Leu Leu Ala Ser Cys Ser 
        355                 360                 365             


Asp Asp Met Thr Leu Lys Ile Trp Ser Met Lys Gln Asp Asn Cys Val 
    370                 375                 380                 


His Asp Leu Gln Ala His Asn Lys Glu Ile Tyr Thr Ile Lys Trp Ser 
385                 390                 395                 400 


Pro Thr Gly Pro Gly Thr Asn Asn Pro Asn Ala Asn Leu Met Leu Ala 
                405                 410                 415     


Ser Ala Ser Phe Asp Ser Thr Val Arg Leu Trp Asp Val Asp Arg Gly 
            420                 425                 430         


Ile Cys Ile His Thr Leu Thr Lys His Gln Glu Pro Val Tyr Ser Val 
        435                 440                 445             


Ala Phe Ser Pro Asp Gly Arg Tyr Leu Ala Ser Gly Ser Phe Asp Lys 
    450                 455                 460                 


Cys Val His Ile Trp Asn Thr Gln Thr Gly Ala Leu Val His Ser Tyr 
465                 470                 475                 480 


Arg Gly Thr Gly Gly Ile Phe Glu Val Cys Trp Asn Ala Ala Gly Asp 
                485                 490                 495     


Lys Val Gly Ala Ser Ala Ser Asp Gly Ser Val Cys Val Leu Asp Leu 
            500                 505                 510         


Arg Lys 
        


<210> 8198
<211> 975
<212> PRT
<213> Homo sapiens

<400> 8198
Met Lys Phe Val Ser Glu Asp Leu His Arg Cys Ala Leu Leu Thr Ala 
1               5                   10                  15      


Asp Ser Phe Gly Asp Pro Phe Phe Pro Arg Thr Thr Gln Ile Leu Leu 
            20                  25                  30          


Glu Tyr Gln Leu Gly Arg Trp Val Pro Arg Leu Arg Glu Pro Arg Asp 
        35                  40                  45              


Leu Tyr Gly Val Ser Ser Ser Gly Pro Leu Ser Pro Thr Arg Trp Pro 
    50                  55                  60                  


Tyr His Cys Glu Val Ile Asp Glu Lys Val Gln His Ile Asp Trp Thr 
65                  70                  75                  80  


Pro Ser Cys Pro Glu Pro Val Tyr Ile Pro Thr Gly Leu Glu Thr Glu 
                85                  90                  95      


Pro Leu Tyr Pro Asp Ser Lys Glu Ala Thr Val Val Tyr Leu Ala Glu 
            100                 105                 110         


Asp Ala Tyr Lys Glu Pro Cys Phe Val Tyr Ser Arg Val Gly Gly Asn 
        115                 120                 125             


Arg Thr Pro Leu Lys Gln Pro Val Asp Tyr Arg Asp Asn Thr Leu Met 
    130                 135                 140                 


Phe Glu Ala Arg Phe Glu Ser Gly Asn Leu Gln Lys Val Val Lys Val 
145                 150                 155                 160 


Ala Glu Tyr Glu Tyr Gln Leu Thr Val Arg Pro Asp Leu Phe Thr Asn 
                165                 170                 175     


Lys His Thr Gln Trp Tyr Tyr Phe Gln Val Thr Asn Met Arg Ala Gly 
            180                 185                 190         


Ile Val Tyr Arg Phe Thr Ile Val Asn Phe Thr Lys Pro Ala Ser Leu 
        195                 200                 205             


Tyr Ser Arg Gly Met Arg Pro Leu Phe Tyr Ser Glu Lys Glu Ala Lys 
    210                 215                 220                 


Ala His His Ile Gly Trp Gln Arg Ile Gly Asp Gln Ile Lys Tyr Tyr 
225                 230                 235                 240 


Arg Asn Asn Pro Gly Gln Asp Gly Arg His Tyr Phe Ser Leu Thr Trp 
                245                 250                 255     


Thr Phe Gln Phe Pro His Asn Lys Asp Thr Cys Tyr Phe Ala His Cys 
            260                 265                 270         


Tyr Pro Tyr Thr Tyr Thr Asn Leu Gln Glu Tyr Leu Ser Gly Ile Asn 
        275                 280                 285             


Asn Asp Pro Val Arg Ser Lys Phe Cys Lys Ile Arg Val Leu Cys His 
    290                 295                 300                 


Thr Leu Ala Arg Asn Met Val Tyr Ile Leu Thr Ile Thr Thr Pro Leu 
305                 310                 315                 320 


Lys Asn Ser Asp Ser Arg Lys Arg Lys Ala Val Ile Leu Thr Ala Arg 
                325                 330                 335     


Val His Pro Gly Glu Thr Asn Ser Ser Trp Ile Met Lys Gly Phe Leu 
            340                 345                 350         


Asp Tyr Ile Leu Gly Asn Ser Ser Asp Ala Gln Leu Leu Arg Asp Thr 
        355                 360                 365             


Phe Val Phe Lys Val Val Pro Met Leu Asn Pro Asp Gly Val Ile Val 
    370                 375                 380                 


Gly Asn Tyr Arg Cys Ser Leu Ala Gly Arg Asp Leu Asn Arg Asn Tyr 
385                 390                 395                 400 


Thr Ser Leu Leu Lys Glu Ser Phe Pro Ser Val Trp Tyr Thr Arg Asn 
                405                 410                 415     


Met Val His Arg Leu Met Glu Lys Arg Glu Val Ile Leu Tyr Cys Asp 
            420                 425                 430         


Leu His Gly His Ser Arg Lys Glu Asn Ile Phe Met Tyr Gly Cys Asp 
        435                 440                 445             


Gly Ser Asp Arg Ser Lys Thr Leu Tyr Leu Gln Gln Arg Ile Phe Pro 
    450                 455                 460                 


Leu Met Leu Ser Lys Asn Cys Pro Asp Lys Phe Ser Phe Ser Ala Cys 
465                 470                 475                 480 


Lys Phe Asn Val Gln Lys Ser Lys Glu Gly Thr Gly Arg Val Val Met 
                485                 490                 495     


Trp Lys Met Gly Ile Arg Asn Ser Phe Thr Met Glu Ala Thr Phe Cys 
            500                 505                 510         


Gly Ser Thr Leu Gly Asn Lys Arg Gly Thr His Phe Ser Thr Lys Asp 
        515                 520                 525             


Leu Glu Ser Met Gly Tyr His Phe Cys Asp Ser Leu Leu Asp Tyr Cys 
    530                 535                 540                 


Asp Pro Asp Arg Thr Lys Tyr Tyr Arg Cys Leu Lys Glu Leu Glu Glu 
545                 550                 555                 560 


Met Glu Arg His Ile Thr Leu Glu Lys Val Phe Glu Asp Ser Asp Thr 
                565                 570                 575     


Pro Val Ile Asp Ile Thr Leu Asp Val Glu Ser Ser Ser Arg Gly Ser 
            580                 585                 590         


Asp Ser Ser Glu Ser Ile Asp Ser Leu Thr Tyr Leu Leu Lys Leu Thr 
        595                 600                 605             


Ser Gln Lys Lys His Leu Lys Thr Lys Lys Glu Arg Asn Ser Thr Ile 
    610                 615                 620                 


Ala Ser His Gln Asn Ala Arg Gly Gln Glu Val Tyr Asp Arg Gly His 
625                 630                 635                 640 


Leu Leu Gln Arg His Thr Gln Ser Asn Ser Asp Val Lys Asp Thr Arg 
                645                 650                 655     


Pro Asn Glu Pro Asp Asp Tyr Met Val Asp Tyr Phe Arg Arg Gln Leu 
            660                 665                 670         


Pro Asn Gln Gly Leu Ala His Cys Lys Leu Arg Leu Pro Gly Ser Arg 
        675                 680                 685             


His Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Thr Thr Gly Thr Arg 
    690                 695                 700                 


His His Thr Trp Leu Ile Phe Val Phe Leu Val Glu Met Gly Lys Lys 
705                 710                 715                 720 


Ile Pro Leu Lys Gly Thr Asp Leu Tyr Gly Asn Cys Phe Lys Val Thr 
                725                 730                 735     


Ser Leu Gln Ser Pro Met Gly Lys Gln Thr Ser Thr Trp Thr Glu Lys 
            740                 745                 750         


Thr Arg Ile Pro Thr Glu Asp Leu His His Asn Leu Lys Ser Lys Ile 
        755                 760                 765             


Lys Glu Cys Ile Ser Phe Gln Ser Lys Lys Thr Gly Ile Asn Trp Thr 
    770                 775                 780                 


Asp Asp Glu Lys Arg Ser Tyr Lys Asp Lys Gly Ile Val Gln Thr Gln 
785                 790                 795                 800 


Glu Ile Leu Gln Tyr Leu Leu Pro Ile Val His Ser Thr Lys Asn Met 
                805                 810                 815     


Gln Thr Thr Gln Ile Lys Gln Leu Phe Asn Pro Arg Thr Asn Phe Gln 
            820                 825                 830         


Ile Gln His Gln Leu Asn Pro Ala Thr Cys Arg Asn Ile Lys Lys Tyr 
        835                 840                 845             


Ser Thr Ser Trp Thr Ala Pro Arg Asn His Pro Phe Val Ile Gln Gly 
    850                 855                 860                 


Asp Val Met Ala Asn Ser Ser Glu Trp Val Gln Ser Lys Pro His Arg 
865                 870                 875                 880 


Ser Leu Glu Ser Leu Ser Pro Leu Lys Gly Pro Lys Lys Asn Lys His 
                885                 890                 895     


Ser Gln Ile Trp Ala Ile Lys Asn Glu Asp Ile Lys Pro Leu Ser Ser 
            900                 905                 910         


Lys Trp Glu Thr Ala Ser Ser Ser Phe Gly Met Asp Ala Asn Val Leu 
        915                 920                 925             


Lys Tyr Lys Ser Leu Gln Ala Glu Glu Thr Asn Gln Gln Ser Ser Lys 
    930                 935                 940                 


His Thr Ala Leu His Leu Thr Lys Asn Lys Asp Glu Gln Ala Asn Lys 
945                 950                 955                 960 


Asn Asp Gly Gln Pro Thr Leu Tyr Leu Lys Phe Gln Arg Glu Ser 
                965                 970                 975 


<210> 8199
<211> 541
<212> PRT
<213> Homo sapiens

<400> 8199
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 
        35                  40                  45              


Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 
65                  70                  75                  80  


Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 
                85                  90                  95      


Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 
            100                 105                 110         


Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro 
        115                 120                 125             


Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys 
    130                 135                 140                 


Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile 
145                 150                 155                 160 


Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu 
                165                 170                 175     


Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile 
            180                 185                 190         


Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln 
        195                 200                 205             


Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser 
    210                 215                 220                 


Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr 
225                 230                 235                 240 


Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly 
                245                 250                 255     


Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr 
            260                 265                 270         


Lys Val Tyr His Glu Asn Ile Lys Thr Gly Val Pro Ala Arg Arg Met 
        275                 280                 285             


Met Lys Asn Gln Val Met Arg Lys Lys Leu Ile Leu Phe Phe Lys Arg 
    290                 295                 300                 


Arg Asn His Ala Arg Lys Gln Arg Glu Gln Lys Ile Cys Gln Arg Tyr 
305                 310                 315                 320 


Asp Gln Leu Met Glu Ala Trp Glu Lys Lys Val Asp Arg Ile Glu Asn 
                325                 330                 335     


Asn Pro Arg Arg Lys Ala Lys Glu Ser Lys Thr Arg Glu Tyr Tyr Glu 
            340                 345                 350         


Lys Gln Phe Pro Glu Ile Arg Lys Gln Arg Glu Gln Gln Glu Arg Phe 
        355                 360                 365             


Gln Arg Val Gly Gln Arg Gly Ala Gly Leu Ser Ala Thr Ile Ala Arg 
    370                 375                 380                 


Ser Glu His Glu Ile Ser Glu Ile Ile Asp Gly Leu Ser Glu Gln Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Gln Met Arg Gln Leu Ser Val Ile Pro Pro Met Met 
                405                 410                 415     


Phe Asp Ala Glu Gln Arg Arg Val Lys Phe Ile Asn Met Asn Gly Leu 
            420                 425                 430         


Met Glu Asp Pro Met Lys Val Tyr Lys Asp Arg Gln Phe Met Asn Val 
        435                 440                 445             


Trp Thr Asp His Glu Lys Glu Ile Phe Lys Asp Lys Phe Ile Gln His 
    450                 455                 460                 


Pro Lys Asn Phe Gly Leu Ile Ala Ser Tyr Leu Glu Arg Lys Ser Val 
465                 470                 475                 480 


Pro Asp Cys Val Leu Tyr Tyr Tyr Leu Thr Lys Lys Asn Glu Asn Tyr 
                485                 490                 495     


Lys Ala Leu Val Arg Arg Asn Tyr Gly Lys Arg Arg Gly Arg Asn Gln 
            500                 505                 510         


Gln Ile Ala Arg Pro Ser Gln Glu Glu Lys Val Glu Glu Lys Glu Glu 
        515                 520                 525             


Asp Lys Ala Glu Lys Thr Glu Lys Lys Glu Glu Glu Lys 
    530                 535                 540     


<210> 8200
<211> 279
<212> PRT
<213> Homo sapiens

<400> 8200
Met Lys Phe Pro Phe Leu Pro Ile Leu Val Met Lys Phe Ile Glu Lys 
1               5                   10                  15      


Ala Gln Asn Met Ser Lys Tyr Val Leu Ile Asp Thr Pro Gly Gln Ile 
            20                  25                  30          


Glu Val Phe Thr Trp Ser Ala Ser Gly Thr Ile Ile Thr Glu Ala Leu 
        35                  40                  45              


Ala Ser Ser Phe Pro Thr Val Val Ile Tyr Val Met Asp Thr Ser Arg 
    50                  55                  60                  


Ser Thr Asn Pro Val Thr Phe Met Ser Asn Met Leu Tyr Ala Cys Ser 
65                  70                  75                  80  


Ile Leu Tyr Lys Thr Lys Leu Pro Phe Ile Val Val Met Asn Lys Thr 
                85                  90                  95      


Asp Ile Ile Asp His Ser Phe Ala Val Glu Trp Met Gln Asp Phe Glu 
            100                 105                 110         


Ala Phe Gln Asp Ala Leu Asn Gln Glu Thr Thr Tyr Val Ser Asn Leu 
        115                 120                 125             


Thr Arg Ser Met Ser Leu Val Leu Asp Glu Phe Tyr Ser Ser Leu Arg 
    130                 135                 140                 


Val Val Gly Val Ser Ala Val Leu Gly Thr Gly Leu Asp Glu Leu Phe 
145                 150                 155                 160 


Val Gln Val Thr Ser Ala Ala Glu Glu Tyr Glu Arg Glu Tyr Arg Pro 
                165                 170                 175     


Glu Tyr Glu Arg Leu Lys Lys Ser Leu Ala Asn Ala Glu Ser Gln Gln 
            180                 185                 190         


Gln Arg Glu Gln Leu Glu Arg Leu Arg Lys Asp Met Gly Ser Val Ala 
        195                 200                 205             


Leu Asp Ala Gly Thr Ala Lys Asp Ser Leu Ser Pro Val Leu His Pro 
    210                 215                 220                 


Ser Asp Leu Ile Leu Thr Arg Gly Thr Leu Asp Glu Glu Asp Glu Glu 
225                 230                 235                 240 


Ala Asp Ser Asp Thr Asp Asp Ile Asp His Arg Val Thr Glu Glu Ser 
                245                 250                 255     


His Glu Glu Pro Ala Phe Gln Asn Phe Met Gln Glu Ser Met Ala Gln 
            260                 265                 270         


Tyr Trp Lys Arg Asn Asn Lys 
        275                 


<210> 8201
<211> 409
<212> PRT
<213> Homo sapiens

<400> 8201
Met Lys Asp Thr Gln Asp Ile Gln Glu Ala Ser Lys Ala Met Gln Asn 
1               5                   10                  15      


Lys Val His Glu Gln Glu Asp Lys Asn Glu Lys Gln Lys Gln Arg Glu 
            20                  25                  30          


Asp Lys Leu Gly Val Tyr Ser Leu Val His Phe Ser Pro Lys Met Leu 
        35                  40                  45              


Gly Ser Val Ala Thr Thr Leu Pro Leu Ser Ser Ser Asn Ser Ser Gly 
    50                  55                  60                  


Met Pro Leu Gly Tyr Tyr Leu Ser Ser Pro Gln Ile Ser Arg Val Thr 
65                  70                  75                  80  


Ile Ser Thr Thr Gly Gln Leu Thr Ser Lys Ala Thr Val Gly Ser Cys 
                85                  90                  95      


Ser Arg Val Glu Asn Ser Leu Asp Ala Ser Pro Phe Ser Val Pro Lys 
            100                 105                 110         


Lys Gln Asp Glu Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu 
        115                 120                 125             


Ser Leu Phe Gly Asp Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr 
    130                 135                 140                 


Gln Lys Thr Leu Lys Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln 
145                 150                 155                 160 


Phe Thr Ser Ser Ser Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val 
                165                 170                 175     


Lys Gly Leu Phe Val Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met 
            180                 185                 190         


Ala Ile Gly Asp His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile 
        195                 200                 205             


Ser Leu Tyr Arg Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr 
    210                 215                 220                 


Val Thr Val Trp Ala Ala Ala Ser Glu Ala Lys His Gln Pro Pro Ser 
225                 230                 235                 240 


Asp Phe Leu Trp Lys Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys 
                245                 250                 255     


Ile Thr Ile Leu Cys Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr 
            260                 265                 270         


Pro Ile His Trp Lys Gln Ala Trp Glu Lys Leu Asp Ala Asp Val Glu 
        275                 280                 285             


Phe Asn Arg Cys Ser Val Val Ser Pro Thr Phe Arg Lys Arg Val Phe 
    290                 295                 300                 


Gln Trp Thr Ala Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln 
305                 310                 315                 320 


Pro Lys Lys Asp Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu 
                325                 330                 335     


Leu Lys Arg Glu Lys Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser 
            340                 345                 350         


Pro Trp Cys Gln Asn Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu 
        355                 360                 365             


Ile Glu Pro His Asn Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln 
    370                 375                 380                 


Pro Arg Thr Arg Ser Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys 
385                 390                 395                 400 


Lys Lys Thr Ser Glu Ser Gln Lys Gln 
                405                 


<210> 8202
<211> 813
<212> PRT
<213> Homo sapiens

<400> 8202
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Glu Ser Ile His Leu Gln Leu Ser Ser 
                85                  90                  95      


Phe Ser Ser Leu Gln Glu Glu Asp Lys Ser Arg Lys Asp Asp Ser Glu 
            100                 105                 110         


Arg Glu Lys Glu Lys Asp Lys Asn Lys Asp Lys Thr Ser Glu Lys Pro 
        115                 120                 125             


Lys Ile Arg Met Leu Ser Lys Asp Cys Ser Gln Glu Tyr Thr Asp Ser 
    130                 135                 140                 


Thr Gly Ile Asp Leu His Glu Phe Leu Ile Asn Thr Leu Lys Asn Asn 
145                 150                 155                 160 


Ser Arg Asp Arg Met Ile Leu Leu Lys Met Glu Gln Glu Ile Ile Asp 
                165                 170                 175     


Phe Ile Ala Asp Asn Asn Asn His Tyr Lys Lys Phe Pro Gln Met Ser 
            180                 185                 190         


Ser Tyr Gln Arg Met Leu Val His Arg Val Ala Ala Tyr Phe Gly Leu 
        195                 200                 205             


Asp His Asn Val Asp Gln Thr Gly Lys Ser Val Ile Ile Asn Lys Thr 
    210                 215                 220                 


Ser Ser Thr Arg Ile Pro Glu Gln Arg Phe Cys Glu His Leu Lys Asp 
225                 230                 235                 240 


Glu Lys Gly Glu Glu Ser Gln Lys Arg Phe Ile Leu Lys Arg Asp Asn 
                245                 250                 255     


Ser Ser Ile Asp Lys Glu Asp Asn Gln Ser Val Cys Ser Gln Glu Ser 
            260                 265                 270         


Leu Phe Val Glu Asn Ser Arg Leu Leu Glu Asp Ser Asn Ile Cys Asn 
        275                 280                 285             


Glu Thr Tyr Lys Lys Arg Gln Leu Phe Arg Gly Asn Arg Asp Gly Ser 
    290                 295                 300                 


Gly Arg Thr Ser Gly Ser Arg Gln Ser Ser Ser Glu Asn Glu Leu Lys 
305                 310                 315                 320 


Trp Ser Asp His Gln Arg Ala Trp Ser Ser Thr Asp Ser Asp Ser Ser 
                325                 330                 335     


Asn Arg Asn Leu Lys Pro Ala Met Thr Lys Thr Ala Ser Phe Gly Gly 
            340                 345                 350         


Ile Thr Val Leu Thr Arg Gly Asp Ser Thr Ser Ser Thr Arg Ser Thr 
        355                 360                 365             


Gly Lys Leu Ser Lys Ala Gly Ser Glu Ser Ser Ser Ser Ala Gly Ser 
    370                 375                 380                 


Ser Gly Ser Leu Ser Arg Thr His Pro Pro Leu Gln Ser Thr Pro Leu 
385                 390                 395                 400 


Val Ser Gly Val Ala Ala Gly Ser Pro Gly Cys Val Pro Tyr Pro Glu 
                405                 410                 415     


Asn Gly Ile Gly Gly Gln Val Ala Pro Ser Ser Thr Ser Tyr Ile Leu 
            420                 425                 430         


Leu Pro Leu Glu Ala Ala Thr Gly Ile Pro Pro Gly Ser Ile Leu Leu 
        435                 440                 445             


Asn Pro His Thr Gly Gln Pro Phe Val Asn Pro Asp Gly Thr Pro Ala 
    450                 455                 460                 


Ile Tyr Asn Pro Pro Thr Ser Gln Gln Pro Leu Arg Ser Ala Met Val 
465                 470                 475                 480 


Gly Gln Ser Gln Gln Gln Pro Pro Gln Gln Gln Pro Ser Pro Gln Pro 
                485                 490                 495     


Gln Gln Gln Val Gln Pro Pro Gln Pro Gln Met Ala Gly Pro Leu Val 
            500                 505                 510         


Thr Gln Ser Val Gln Gly Leu Gln Ala Ser Ser Gln Ser Val Gln Tyr 
        515                 520                 525             


Pro Ala Val Ser Phe Pro Pro Gln His Leu Leu Pro Val Ser Pro Thr 
    530                 535                 540                 


Gln His Phe Pro Met Arg Asp Asp Val Ala Thr Gln Phe Gly Gln Met 
545                 550                 555                 560 


Thr Leu Ser Arg Gln Ser Ser Gly Glu Thr Pro Glu Pro Pro Ser Gly 
                565                 570                 575     


Pro Val Tyr Pro Ser Ser Leu Met Pro Gln Pro Ala Gln Gln Pro Ser 
            580                 585                 590         


Tyr Val Ile Ala Ser Thr Gly Gln Gln Leu Pro Thr Gly Gly Phe Ser 
        595                 600                 605             


Gly Ser Gly Pro Pro Ile Ser Gln Gln Val Leu Gln Pro Pro Pro Ser 
    610                 615                 620                 


Pro Gln Gly Phe Val Gln Gln Pro Pro Pro Ala Gln Met Pro Val Tyr 
625                 630                 635                 640 


Tyr Tyr Pro Ser Gly Gln Tyr Pro Thr Ser Thr Thr Gln Gln Tyr Arg 
                645                 650                 655     


Pro Met Ala Pro Val Gln Tyr Asn Ala Gln Arg Ser Gln Gln Met Pro 
            660                 665                 670         


Gln Ala Ala Gln Gln Ala Gly Tyr Gln Pro Val Leu Ser Gly Gln Gln 
        675                 680                 685             


Gly Phe Gln Gly Leu Ile Gly Val Gln Gln Pro Pro Gln Ser Gln Asn 
    690                 695                 700                 


Val Ile Asn Asn Gln Gln Gly Thr Pro Val Gln Ser Val Met Val Ser 
705                 710                 715                 720 


Tyr Pro Thr Met Ser Ser Tyr Gln Val Pro Met Thr Gln Gly Ser Gln 
                725                 730                 735     


Gly Leu Pro Gln Gln Ser Tyr Gln Gln Pro Ile Met Leu Pro Asn Gln 
            740                 745                 750         


Ala Gly Gln Gly Ser Leu Pro Ala Thr Gly Met Pro Val Tyr Cys Asn 
        755                 760                 765             


Val Thr Pro Pro Thr Pro Gln Asn Asn Leu Arg Leu Ile Gly Pro His 
    770                 775                 780                 


Cys Pro Ser Ser Thr Val Pro Val Met Ser Ala Ser Cys Arg Thr Asn 
785                 790                 795                 800 


Cys Ala Ser Met Ser Asn Ala Gly Trp Gln Val Lys Phe 
                805                 810             


<210> 8203
<211> 590
<212> PRT
<213> Homo sapiens

<400> 8203
Met Pro Ser Pro Gln Leu Leu Val Leu Phe Gly Ser Gln Thr Gly Thr 
1               5                   10                  15      


Ala Gln Asp Val Ser Glu Arg Leu Gly Arg Glu Ala Arg Arg Arg Arg 
            20                  25                  30          


Leu Gly Cys Arg Val Gln Ala Leu Asp Ser Tyr Pro Val Val Asn Leu 
        35                  40                  45              


Ile Asn Glu Pro Leu Val Ile Phe Val Cys Ala Thr Thr Gly Gln Gly 
    50                  55                  60                  


Asp Pro Pro Asp Asn Met Lys Asn Phe Trp Arg Phe Ile Phe Arg Lys 
65                  70                  75                  80  


Asn Leu Pro Ser Thr Ala Leu Cys Gln Met Asp Phe Ala Val Leu Gly 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Ala Lys Phe Asn Phe Val Ala Lys Lys Leu 
            100                 105                 110         


His Arg Arg Leu Leu Gln Leu Gly Gly Ser Ala Leu Leu Pro Val Cys 
        115                 120                 125             


Leu Gly Asp Asp Gln His Glu Leu Gly Pro Asp Ala Ala Val Asp Pro 
    130                 135                 140                 


Trp Leu Arg Asp Leu Trp Asp Arg Val Leu Gly Leu Tyr Pro Pro Pro 
145                 150                 155                 160 


Pro Gly Leu Thr Glu Ile Pro Pro Gly Val Pro Leu Pro Ser Lys Phe 
                165                 170                 175     


Thr Leu Leu Phe Leu Gln Glu Ala Pro Ser Thr Gly Ser Glu Gly Gln 
            180                 185                 190         


Arg Val Ala His Pro Gly Ser Gln Glu Pro Pro Ser Glu Ser Lys Pro 
        195                 200                 205             


Phe Leu Ala Pro Met Ile Ser Asn Gln Arg Val Thr Gly Pro Ser His 
    210                 215                 220                 


Phe Gln Asp Val Arg Leu Ile Glu Phe Asp Ile Leu Gly Ser Gly Ile 
225                 230                 235                 240 


Ser Phe Ala Ala Gly Asp Val Val Leu Ile Gln Pro Ser Asn Ser Ala 
                245                 250                 255     


Ala His Val Gln Arg Phe Cys Gln Val Leu Gly Leu Asp Pro Asp Gln 
            260                 265                 270         


Leu Phe Met Leu Gln Pro Arg Glu Pro Asp Val Ser Ser Pro Thr Arg 
        275                 280                 285             


Leu Pro Gln Pro Cys Ser Met Arg His Leu Val Ser His Tyr Leu Asp 
    290                 295                 300                 


Ile Ala Ser Val Pro Arg Arg Ser Phe Phe Glu Leu Leu Ala Cys Leu 
305                 310                 315                 320 


Ser Leu His Glu Leu Glu Arg Glu Lys Leu Leu Glu Phe Ser Ser Ala 
                325                 330                 335     


Gln Gly Gln Glu Glu Leu Phe Glu Tyr Cys Asn Arg Pro Arg Arg Thr 
            340                 345                 350         


Ile Leu Glu Val Leu Cys Asp Phe Pro His Thr Ala Ala Ala Ile Pro 
        355                 360                 365             


Pro Asp Tyr Leu Leu Asp Leu Ile Pro Val Ile Arg Pro Arg Ala Phe 
    370                 375                 380                 


Ser Ile Ala Ser Ser Leu Leu Ile Leu Val Ala Val Val Gln Phe Gln 
385                 390                 395                 400 


Thr Arg Leu Lys Glu Pro Arg Arg Gly Leu Cys Ser Ser Trp Leu Ala 
                405                 410                 415     


Ser Leu Asp Pro Gly Gln Gly Pro Val Arg Val Pro Leu Trp Val Arg 
            420                 425                 430         


Pro Gly Ser Leu Ala Phe Pro Glu Thr Pro Asp Thr Pro Val Ile Met 
        435                 440                 445             


Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Ala Ala Ile Gln Glu 
    450                 455                 460                 


Arg Val Ala Gln Gly Gln Thr Gly Asn Phe Leu Phe Phe Gly Cys Arg 
465                 470                 475                 480 


Trp Arg Asp Gln Asp Phe Tyr Trp Glu Ala Glu Trp Gln Glu Leu Glu 
                485                 490                 495     


Lys Arg Asp Cys Leu Thr Leu Ile Pro Ala Phe Ser Arg Glu Gln Glu 
            500                 505                 510         


Gln Lys Val Tyr Val Gln His Arg Leu Arg Glu Leu Gly Ser Leu Val 
        515                 520                 525             


Trp Glu Leu Leu Asp Arg Gln Gly Ala Tyr Phe Tyr Leu Ala Gly Asn 
    530                 535                 540                 


Ala Lys Ser Met Pro Ala Asp Val Ser Glu Ala Leu Met Ser Ile Phe 
545                 550                 555                 560 


Gln Glu Glu Gly Gly Leu Cys Ser Pro Asp Ala Ala Ala Tyr Leu Ala 
                565                 570                 575     


Arg Leu Gln Gln Thr Arg Arg Phe Gln Thr Glu Thr Trp Ala 
            580                 585                 590 


<210> 8204
<211> 811
<212> PRT
<213> Homo sapiens

<400> 8204
Met Pro Leu Ser Ser Pro Asn Ala Ala Ala Thr Ala Ser Asp Met Asp 
1               5                   10                  15      


Lys Asn Ser Gly Ser Asn Ser Ser Ser Ala Ser Ser Gly Ser Ser Lys 
            20                  25                  30          


Gly Gln Gln Pro Pro Arg Ser Ala Ser Ala Gly Pro Ala Gly Glu Ser 
        35                  40                  45              


Lys Pro Lys Ser Asp Gly Lys Asn Ser Ser Gly Ser Lys Arg Tyr Asn 
    50                  55                  60                  


Arg Lys Arg Glu Leu Ser Tyr Pro Lys Asn Glu Ser Phe Asn Asn Gln 
65                  70                  75                  80  


Ser Arg Arg Ser Ser Ser Gln Lys Ser Lys Thr Phe Asn Lys Met Pro 
                85                  90                  95      


Pro Gln Arg Gly Gly Gly Ser Ser Lys Leu Phe Ser Ser Ser Phe Asn 
            100                 105                 110         


Gly Gly Arg Arg Asp Glu Val Ala Glu Ala Gln Arg Ala Glu Phe Ser 
        115                 120                 125             


Pro Ala Gln Phe Ser Gly Pro Lys Lys Ile Asn Leu Asn His Leu Leu 
    130                 135                 140                 


Asn Phe Thr Phe Glu Pro Arg Gly Gln Thr Gly His Phe Glu Gly Ser 
145                 150                 155                 160 


Gly His Gly Ser Trp Gly Lys Arg Asn Lys Trp Gly His Lys Pro Phe 
                165                 170                 175     


Asn Lys Glu Leu Phe Leu Gln Ala Asn Cys Gln Phe Val Val Ser Glu 
            180                 185                 190         


Asp Gln Asp Tyr Thr Ala His Phe Ala Asp Pro Asp Thr Leu Val Asn 
        195                 200                 205             


Trp Asp Phe Val Glu Gln Val Arg Ile Cys Ser His Glu Val Pro Ser 
    210                 215                 220                 


Cys Pro Ile Cys Leu Tyr Pro Pro Thr Ala Ala Lys Ile Thr Arg Cys 
225                 230                 235                 240 


Gly His Ile Phe Cys Trp Ala Cys Ile Leu His Tyr Leu Ser Leu Ser 
                245                 250                 255     


Glu Lys Thr Trp Ser Lys Cys Pro Ile Cys Tyr Ser Ser Val His Lys 
            260                 265                 270         


Lys Asp Leu Lys Ser Val Val Ala Thr Glu Ser His Gln Tyr Val Val 
        275                 280                 285             


Gly Asp Thr Ile Thr Met Gln Leu Met Lys Arg Glu Lys Gly Val Leu 
    290                 295                 300                 


Val Ala Leu Pro Lys Ser Lys Trp Met Asn Val Asp His Pro Ile His 
305                 310                 315                 320 


Leu Gly Asp Glu Gln His Ser Gln Tyr Ser Lys Leu Leu Leu Ala Ser 
                325                 330                 335     


Lys Glu Gln Val Leu His Arg Val Val Leu Glu Glu Lys Val Ala Leu 
            340                 345                 350         


Glu Gln Gln Leu Ala Glu Glu Lys His Thr Pro Glu Ser Cys Phe Ile 
        355                 360                 365             


Glu Ala Ala Ile Gln Glu Leu Lys Thr Arg Glu Glu Ala Leu Ser Gly 
    370                 375                 380                 


Leu Ala Gly Ser Arg Arg Glu Val Thr Gly Val Val Ala Ala Leu Glu 
385                 390                 395                 400 


Gln Leu Val Leu Met Ala Pro Leu Ala Lys Glu Ser Val Phe Gln Pro 
                405                 410                 415     


Arg Lys Gly Val Leu Glu Tyr Leu Ser Ala Phe Asp Glu Glu Thr Thr 
            420                 425                 430         


Glu Val Cys Ser Leu Asp Thr Pro Ser Arg Pro Leu Ala Leu Pro Leu 
        435                 440                 445             


Val Glu Glu Glu Glu Ala Val Ser Glu Pro Glu Pro Glu Gly Leu Pro 
    450                 455                 460                 


Glu Ala Cys Asp Asp Leu Glu Leu Ala Asp Asp Asn Leu Lys Glu Gly 
465                 470                 475                 480 


Thr Ile Cys Thr Glu Ser Ser Gln Gln Glu Pro Ile Thr Lys Ser Gly 
                485                 490                 495     


Phe Thr Arg Leu Ser Ser Ser Pro Cys Tyr Tyr Phe Tyr Gln Ala Glu 
            500                 505                 510         


Asp Gly Gln His Met Phe Leu His Pro Val Asn Val Arg Cys Leu Val 
        515                 520                 525             


Arg Glu Tyr Gly Ser Leu Glu Arg Ser Pro Glu Lys Ile Ser Ala Thr 
    530                 535                 540                 


Val Val Glu Ile Ala Gly Tyr Ser Met Ser Glu Asp Val Arg Gln Arg 
545                 550                 555                 560 


His Arg Tyr Leu Ser His Leu Pro Leu Thr Cys Glu Phe Ser Ile Cys 
                565                 570                 575     


Glu Leu Ala Leu Gln Pro Pro Val Val Ser Lys Glu Thr Leu Glu Met 
            580                 585                 590         


Phe Ser Asp Asp Ile Glu Lys Arg Lys Arg Gln Arg Gln Lys Lys Ala 
        595                 600                 605             


Arg Glu Glu Arg Arg Arg Glu Arg Arg Ile Glu Ile Glu Glu Asn Lys 
    610                 615                 620                 


Lys Gln Gly Lys Tyr Pro Glu Val His Ile Pro Leu Glu Asn Leu Gln 
625                 630                 635                 640 


Gln Phe Pro Ala Phe Asn Ser Tyr Thr Cys Ser Ser Asp Ser Ala Leu 
                645                 650                 655     


Gly Pro Thr Ser Thr Glu Gly His Gly Ala Leu Ser Ile Ser Pro Leu 
            660                 665                 670         


Ser Arg Ser Pro Gly Ser His Ala Asp Phe Leu Leu Thr Pro Leu Ser 
        675                 680                 685             


Pro Thr Ala Ser Gln Gly Ser Pro Ser Phe Cys Val Gly Ser Leu Glu 
    690                 695                 700                 


Glu Asp Ser Pro Phe Pro Ser Phe Ala Gln Met Leu Arg Val Gly Lys 
705                 710                 715                 720 


Ala Lys Ala Asp Val Trp Pro Lys Thr Ala Pro Lys Lys Asp Glu Asn 
                725                 730                 735     


Ser Leu Val Pro Pro Ala Pro Val Asp Ser Asp Gly Glu Ser Asp Asn 
            740                 745                 750         


Ser Asp Arg Val Pro Val Pro Ser Phe Gln Asn Ser Phe Ser Gln Ala 
        755                 760                 765             


Ile Glu Ala Ala Phe Met Lys Leu Asp Thr Pro Ala Thr Ser Asp Pro 
    770                 775                 780                 


Leu Ser Glu Glu Lys Gly Gly Lys Lys Arg Lys Lys Gln Lys Gln Lys 
785                 790                 795                 800 


Leu Leu Phe Ser Thr Ser Val Val His Thr Lys 
                805                 810     


<210> 8205
<211> 62
<212> PRT
<213> Homo sapiens

<400> 8205
Met Pro Glu Ile Arg Val Thr Pro Leu Gly Ala Cys Pro Val Leu Ser 
1               5                   10                  15      


Trp Asn Leu Val Leu Pro Pro Gly Arg Gly Ser Arg Ala Pro Ser Ser 
            20                  25                  30          


Thr Asp Thr Arg Thr Gly Phe His Val Leu Pro His Gly Val Ser Ala 
        35                  40                  45              


Ser Ser Glu Gly Ala Pro Arg Pro Gly Val Asp Thr Val Leu 
    50                  55                  60          


<210> 8206
<211> 315
<212> PRT
<213> Homo sapiens

<400> 8206
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu Ala Gln Val Met Leu Ala Leu Ala Ser His Leu Ser 
                85                  90                  95      


Thr Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu 
            100                 105                 110         


Cys Gln Glu Asn Gln Trp Leu Arg Asp Glu Leu Ala Gly Thr Gln Gln 
        115                 120                 125             


Arg Leu Gln Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu Glu Lys 
    130                 135                 140                 


Lys His Leu Glu Phe Leu Gly Gln Leu Arg Gln Tyr Asp Glu Asp Gly 
145                 150                 155                 160 


His Thr Ser Glu Glu Lys Glu Gly Asp Ala Thr Lys Asp Ser Leu Asp 
                165                 170                 175     


Asp Leu Phe Pro Asn Glu Glu Glu Glu Asp Pro Ser Asn Gly Leu Ser 
            180                 185                 190         


Arg Gly Gln Gly Ala Thr Ala Ala Gln Gln Gly Gly Tyr Glu Ile Pro 
        195                 200                 205             


Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala Ala Gln 
    210                 215                 220                 


Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu Glu Asp 
225                 230                 235                 240 


Leu Glu Arg Thr Ser Gly Arg Gly His Pro Asp Val Ala Thr Met Leu 
                245                 250                 255     


Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys Glu Ala 
            260                 265                 270         


Ala His Leu Leu Asn Asp Ala Leu Ser Ile Arg Glu Ser Thr Leu Gly 
        275                 280                 285             


Pro Asp His Pro Ala Val Ser Ile Pro Cys Pro Pro His Pro Thr Pro 
    290                 295                 300                 


Arg Thr Pro His His Cys Cys Phe Gly Leu Ser 
305                 310                 315 


<210> 8207
<211> 684
<212> PRT
<213> Homo sapiens

<400> 8207
Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys 
1               5                   10                  15      


Lys Leu Asn Gly Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met 
            20                  25                  30          


Ile Thr Asp Ile His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr 
        35                  40                  45              


Val Lys Lys Glu His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr 
    50                  55                  60                  


Asp Gly Glu His Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu 
65                  70                  75                  80  


His Leu Asn Pro Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser 
                85                  90                  95      


Ser Gln Ser Ser Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser 
            100                 105                 110         


Gln Glu Ser Met Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln 
        115                 120                 125             


Val Leu Pro Gly Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu 
    130                 135                 140                 


Thr Gln Thr Val Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly 
145                 150                 155                 160 


Gly Glu Lys Arg Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg 
                165                 170                 175     


Glu Phe Thr Leu Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile 
            180                 185                 190         


Tyr Cys Ser Arg Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu 
        195                 200                 205             


Gly Ile Leu Pro Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr 
    210                 215                 220                 


Asp Ala Gln Arg Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro 
225                 230                 235                 240 


Gln Asn Gly Ser Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys 
                245                 250                 255     


Glu Thr Gly Ser Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys 
            260                 265                 270         


Gln Gly Leu Phe Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys 
        275                 280                 285             


Ile Gln Cys Leu Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val 
    290                 295                 300                 


Met His Ser His Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe 
305                 310                 315                 320 


Glu Ser Ala Lys Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu 
                325                 330                 335     


Gly Thr Pro Glu Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys 
            340                 345                 350         


Glu Lys Phe Ser Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp 
        355                 360                 365             


Ala Pro Ser Gly Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln 
    370                 375                 380                 


Glu Gly Asp His Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr 
385                 390                 395                 400 


Tyr Leu Tyr Met Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr 
                405                 410                 415     


Ser Ala Val Ser Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Ser Lys 
            420                 425                 430         


Ser Ile Ser Arg Gln Ser Glu Lys Ala His Ser Ser Gly Lys Leu Gln 
        435                 440                 445             


Lys Thr Val Ser Tyr Pro Asp Val Ser Leu Glu Glu Gln Glu Lys Met 
    450                 455                 460                 


Asp Leu Lys Thr Ser Arg Glu Leu Cys Ser Arg Leu Asp Ala Ser Ile 
465                 470                 475                 480 


Ser Asn Asn Ser Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr Cys Asn 
                485                 490                 495     


Leu Val Arg Asp Ile Asn Lys Val Gly Ile Gly Leu Val Ala Ala Ala 
            500                 505                 510         


Ser Ser Pro Leu Leu Val Lys Asp Val Ile Cys Glu Asp Asp Lys Gly 
        515                 520                 525             


Lys Ile Met Glu Glu Val Met Arg Thr Tyr Leu Lys Gln Gln Glu Lys 
    530                 535                 540                 


Leu Asn Leu Ile Leu Gln Lys Lys Gln Gln Leu Gln Met Glu Val Lys 
545                 550                 555                 560 


Met Leu Ser Ser Ser Lys Ser Met Lys Glu Leu Thr Glu Glu Gln Gln 
                565                 570                 575     


Asn Leu Gln Lys Glu Leu Glu Ser Leu Gln Asn Glu His Ala Gln Arg 
            580                 585                 590         


Met Glu Glu Phe Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys Leu Glu 
        595                 600                 605             


Gln Ile Met Lys Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu Lys Asp 
    610                 615                 620                 


Lys Glu Ala Glu Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln Arg Leu 
625                 630                 635                 640 


Asp His Ala Glu Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu Arg Gln 
                645                 650                 655     


Glu Arg Glu Ala Arg Gln Lys Leu Glu Met Met Ile Lys Glu Leu Lys 
            660                 665                 670         


Leu Gln Ile Leu Lys Ser Ser Lys Thr Ala Lys Glu 
        675                 680                 


<210> 8208
<211> 1349
<212> PRT
<213> Homo sapiens

<400> 8208
Met Glu Glu Asn Glu Ser Gln Lys Cys Glu Pro Cys Leu Pro Tyr Ser 
1               5                   10                  15      


Ala Asp Arg Arg Gln Met Gln Glu Gln Gly Lys Gly Asn Leu His Val 
            20                  25                  30          


Thr Ser Pro Glu Asp Ala Glu Cys Arg Arg Thr Lys Glu Arg Leu Ser 
        35                  40                  45              


Asn Gly Asn Ser Arg Gly Ser Val Ser Lys Ser Ser Arg Asn Ile Pro 
    50                  55                  60                  


Arg Arg His Thr Leu Gly Gly Pro Arg Ser Ser Lys Glu Ile Leu Gly 
65                  70                  75                  80  


Met Gln Thr Ser Glu Met Asp Arg Lys Arg Glu Ala Phe Leu Glu His 
                85                  90                  95      


Leu Lys Gln Lys Tyr Pro His His Ala Ser Ala Ile Met Gly His Gln 
            100                 105                 110         


Glu Arg Leu Arg Asp Gln Thr Arg Ser Pro Lys Leu Ser His Ser Pro 
        115                 120                 125             


Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr Ser 
    130                 135                 140                 


Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro Phe 
145                 150                 155                 160 


Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser Thr 
                165                 170                 175     


Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr Gly 
            180                 185                 190         


Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala Asp 
        195                 200                 205             


Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met 
    210                 215                 220                 


Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser 
225                 230                 235                 240 


Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg 
                245                 250                 255     


Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His 
            260                 265                 270         


Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val 
        275                 280                 285             


Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala 
    290                 295                 300                 


His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro 
305                 310                 315                 320 


His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg 
                325                 330                 335     


Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser 
            340                 345                 350         


Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu 
        355                 360                 365             


Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile 
    370                 375                 380                 


Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His 
385                 390                 395                 400 


Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp 
                405                 410                 415     


Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala 
            420                 425                 430         


Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln 
        435                 440                 445             


Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro 
    450                 455                 460                 


Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp 
465                 470                 475                 480 


Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro 
                485                 490                 495     


His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys 
            500                 505                 510         


Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala 
        515                 520                 525             


Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln 
    530                 535                 540                 


Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Ser 
545                 550                 555                 560 


Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr Asp Ser Ala 
                565                 570                 575     


Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala Leu Glu Ser 
            580                 585                 590         


Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser Ala Ile His 
        595                 600                 605             


Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu Arg Leu Gln 
    610                 615                 620                 


Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu Leu Leu Arg 
625                 630                 635                 640 


Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys Val Met Glu 
                645                 650                 655     


Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg Val Leu Val 
            660                 665                 670         


Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys Ile Val Lys 
        675                 680                 685             


Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys Lys Asp Ser 
    690                 695                 700                 


Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu Asp Gly Ala 
705                 710                 715                 720 


Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu Lys Gly Glu 
                725                 730                 735     


Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg Ile Glu Val 
            740                 745                 750         


Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu Asp Ser Leu 
        755                 760                 765             


Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met Leu Arg Arg 
    770                 775                 780                 


His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala Gln Ala Ala 
785                 790                 795                 800 


Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val Leu Lys Ser 
                805                 810                 815     


Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His Ser Thr Gly 
            820                 825                 830         


Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser Gly Met Met 
        835                 840                 845             


Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro Ser Gln His 
    850                 855                 860                 


Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His Val Ala Ser 
865                 870                 875                 880 


Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln Met Ser Gln 
                885                 890                 895     


Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala Met Gln Ser 
            900                 905                 910         


Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn Arg Ala Val 
        915                 920                 925             


Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg Gln Asn Leu 
    930                 935                 940                 


Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu Glu Ala Gln 
945                 950                 955                 960 


Ala Asn Ile Met Lys Ser Ile Pro Asn Leu Glu Met Pro Pro Ala Thr 
                965                 970                 975     


Gly Pro Leu Pro Arg Gly Asp Ala Pro Val Asp Lys Val Glu Leu Ser 
            980                 985                 990         


Glu Asp Ser Pro Asn Ser Glu Gln  Asp Leu Glu Lys Leu  Gly Gly Lys 
        995                 1000                 1005             


Ser Pro  Pro Pro Pro Pro Pro  Pro Pro Arg Arg Ser  Tyr Leu Pro 
    1010                 1015                 1020             


Gly Ser  Gly Leu Thr Thr Thr  Arg Ser Gly Asp Val  Val Tyr Thr 
    1025                 1030                 1035             


Gly Arg  Lys Glu Asn Ile Thr  Ala Lys Ala Ser Ser  Glu Asp Ala 
    1040                 1045                 1050             


Gly Pro  Ser Pro Gln Thr Arg  Ala Thr Lys Tyr Pro  Ala Glu Glu 
    1055                 1060                 1065             


Pro Ala  Ser Ala Trp Thr Pro  Ser Pro Pro Pro Val  Thr Thr Ser 
    1070                 1075                 1080             


Ser Ser  Lys Asp Glu Glu Glu  Glu Glu Glu Glu Gly  Asp Lys Ile 
    1085                 1090                 1095             


Met Ala  Glu Leu Gln Ala Phe  Gln Lys Cys Ser Phe  Met Asp Val 
    1100                 1105                 1110             


Asn Ser  Asn Ser His Ala Glu  Pro Ser Arg Ala Asp  Ser His Val 
    1115                 1120                 1125             


Lys Asp  Thr Arg Ser Gly Ala  Thr Val Pro Pro Lys  Glu Lys Lys 
    1130                 1135                 1140             


Gly Ser  Ser Gly Ala Pro Gln  Thr Ser Arg Met Pro  Val Pro Met 
    1145                 1150                 1155             


Ser Ala  Lys Asn Arg Pro Gly  Thr Leu Asp Lys Pro  Gly Lys Gln 
    1160                 1165                 1170             


Ser Lys  Leu Gln Asp Pro Arg  Gln Tyr Arg Gln Ala  Asn Gly Ser 
    1175                 1180                 1185             


Ala Lys  Lys Ser Gly Gly Asp  Phe Lys Pro Thr Ser  Pro Ser Leu 
    1190                 1195                 1200             


Pro Ala  Ser Lys Ile Pro Ala  Leu Ser Pro Ser Ser  Gly Lys Ser 
    1205                 1210                 1215             


Ser Ser  Leu Pro Ser Ser Ser  Gly Asp Ser Ser Asn  Leu Pro Asn 
    1220                 1225                 1230             


Pro Pro  Ala Thr Lys Pro Ser  Ile Ala Ser Asn Pro  Leu Ser Pro 
    1235                 1240                 1245             


Gln Thr  Gly Pro Pro Ala His  Ser Ala Ser Leu Ile  Pro Ser Val 
    1250                 1255                 1260             


Ser Asn  Gly Ser Leu Lys Phe  Gln Ser Leu Thr His  Thr Gly Lys 
    1265                 1270                 1275             


Gly His  His Leu Ser Phe Ser  Pro Gln Ser Gln Asn  Gly Arg Ala 
    1280                 1285                 1290             


Pro Pro  Pro Leu Ser Phe Ser  Ser Ser Pro Pro Ser  Pro Ala Ser 
    1295                 1300                 1305             


Ser Val  Ser Leu Asn Gln Gly  Ala Lys Gly Thr Arg  Thr Ile His 
    1310                 1315                 1320             


Thr Pro  Ser Leu Thr Ser Tyr  Lys Ala Gln Asn Gly  Ser Ser Ser 
    1325                 1330                 1335             


Lys Ala  Thr Pro Ser Thr Ala  Lys Glu Thr Ser 
    1340                 1345                 


<210> 8209
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8209
Xaa Ile Ile His Lys Leu Ala Met Gln Leu Arg His Ile Gly Asp Asn 
1               5                   10                  15      


Ile Asp His Arg Met Val Arg Glu Asp Leu Gln Gln Asp Gly Arg Asp 
            20                  25                  30          


Ala Leu Asp His Phe Val Phe Phe Phe Phe Arg Arg Val Gln Val Leu 
        35                  40                  45              


Leu His Phe Phe Trp Asn Asn His Leu Leu 
    50                  55              


<210> 8210
<211> 142
<212> PRT
<213> Homo sapiens

<400> 8210
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser Glu Leu Leu 
            100                 105                 110         


Met Ile Ile Gln Met Glu Thr Gln Ser Ser Met Arg Lys Lys Val Cys 
        115                 120                 125             


Asp Ile Ala Ala Glu Leu Ala Arg Asn Leu Ile Gly Val Tyr 
    130                 135                 140         


<210> 8211
<211> 30
<212> PRT
<213> Homo sapiens

<400> 8211
Met Gly Ser Arg Lys Lys Glu Ile Ala Leu Gln Val Asn Ile Ser Thr 
1               5                   10                  15      


Gln Glu Leu Trp Glu Glu Met Leu Ser Ser Lys Gly Leu Thr 
            20                  25                  30  


<210> 8212
<211> 214
<212> PRT
<213> Homo sapiens

<400> 8212
Met Ala Gly Glu Asn Phe Ala Thr Pro Phe His Gly His Val Gly Arg 
1               5                   10                  15      


Gly Ala Phe Ser Asp Val Tyr Glu Pro Ala Glu Asp Thr Phe Leu Leu 
            20                  25                  30          


Leu Asn Ala Leu Glu Ala Ala Ala Ala Glu Leu Ala Gly Val Glu Ile 
        35                  40                  45              


Cys Leu Glu Val Gly Ser Gly Ser Gly Val Val Ser Ala Phe Leu Ala 
    50                  55                  60                  


Ser Met Ile Gly Pro Gln Ala Leu Tyr Met Cys Thr Asp Ile Asn Pro 
65                  70                  75                  80  


Glu Ala Ala Ala Cys Thr Leu Glu Thr Ala Arg Cys Asn Lys Val His 
                85                  90                  95      


Ile Gln Pro Val Ile Thr Asp Leu Val Lys Gly Leu Leu Pro Arg Leu 
            100                 105                 110         


Thr Glu Lys Val Asp Leu Leu Val Phe Asn Pro Pro Tyr Val Val Thr 
        115                 120                 125             


Pro Pro Gln Glu Val Gly Ser His Gly Ile Glu Ala Ala Trp Ala Gly 
    130                 135                 140                 


Gly Lys Asn Gly Arg Glu Val Met Asp Arg Phe Phe Pro Leu Val Pro 
145                 150                 155                 160 


Asp Leu Leu Ser Pro Lys Gly Leu Phe Tyr Leu Val Thr Ile Lys Glu 
                165                 170                 175     


Asn Asn Pro Glu Glu Ile Leu Lys Ile Met Lys Thr Lys Gly Leu Gln 
            180                 185                 190         


Gly Thr Thr Ala Leu Ser Arg Gln Ala Gly Gln Glu Thr Leu Ser Val 
        195                 200                 205             


Leu Lys Phe Thr Lys Ser 
    210                 


<210> 8213
<211> 385
<212> PRT
<213> Homo sapiens

<400> 8213
Met Gly Arg Trp Cys Gln Thr Val Ala Arg Gly Gln Arg Pro Arg Thr 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ala Gly Ala Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Arg Ser Ala Gly Cys Trp Gly Ala Gly Glu Ala Pro Gly Ala Leu Ser 
        35                  40                  45              


Thr Ala Asp Pro Ala Asp Gln Ser Val Gln Cys Val Pro Lys Ala Thr 
    50                  55                  60                  


Cys Pro Ser Ser Arg Pro Arg Leu Leu Trp Gln Thr Pro Thr Thr Gln 
65                  70                  75                  80  


Thr Leu Pro Ser Thr Thr Met Glu Thr Gln Phe Pro Val Ser Glu Gly 
                85                  90                  95      


Lys Val Asp Pro Tyr Arg Ser Cys Gly Phe Ser Tyr Glu Gln Asp Pro 
            100                 105                 110         


Thr Leu Arg Asp Pro Glu Ala Val Ala Arg Arg Trp Pro Trp Met Val 
        115                 120                 125             


Ser Val Arg Ala Asn Gly Thr His Ile Cys Ala Gly Thr Ile Ile Ala 
    130                 135                 140                 


Ser Gln Trp Val Leu Thr Val Ala His Cys Leu Ile Trp Arg Asp Val 
145                 150                 155                 160 


Ile Tyr Ser Val Arg Val Gly Ser Pro Trp Ile Asp Gln Met Thr Gln 
                165                 170                 175     


Thr Ala Ser Asp Val Pro Val Leu Gln Val Ile Met His Ser Arg Tyr 
            180                 185                 190         


Arg Ala Gln Arg Phe Trp Ser Trp Val Gly Gln Ala Asn Asp Ile Gly 
        195                 200                 205             


Leu Leu Lys Leu Lys Gln Glu Leu Lys Tyr Ser Asn Tyr Val Arg Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Thr Asp Tyr Val Leu Lys Asp His Ser Arg Cys 
225                 230                 235                 240 


Thr Val Thr Gly Trp Gly Leu Ser Lys Ala Asp Gly Met Trp Pro Gln 
                245                 250                 255     


Phe Arg Thr Ile Gln Glu Lys Glu Val Ile Ile Leu Asn Asn Lys Glu 
            260                 265                 270         


Cys Asp Asn Phe Tyr His Asn Phe Thr Lys Ile Pro Thr Leu Val Gln 
        275                 280                 285             


Ile Ile Lys Ser Gln Met Met Cys Ala Glu Asp Thr His Arg Glu Lys 
    290                 295                 300                 


Phe Cys Tyr Glu Leu Thr Gly Glu Pro Leu Val Cys Ser Met Glu Gly 
305                 310                 315                 320 


Thr Trp Tyr Leu Val Gly Leu Val Ser Trp Gly Ala Gly Cys Gln Lys 
                325                 330                 335     


Ser Glu Ala Pro Pro Ile Tyr Leu Gln Val Ser Ser Tyr Gln His Trp 
            340                 345                 350         


Ile Trp Asp Cys Leu Asn Gly Gln Ala Leu Ala Leu Pro Ala Pro Ser 
        355                 360                 365             


Arg Thr Leu Leu Leu Ala Leu Pro Leu Pro Leu Ser Leu Leu Ala Ala 
    370                 375                 380                 


Leu 
385 


<210> 8214
<211> 84
<212> PRT
<213> Homo sapiens

<400> 8214
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu 
                


<210> 8215
<211> 160
<212> PRT
<213> Homo sapiens

<400> 8215
Met Ser Val Asn Ser Glu Lys Ser Ser Ser Ser Glu Arg Pro Glu Pro 
1               5                   10                  15      


Gln Gln Lys Ala Pro Leu Val Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Asp Pro Thr Pro Pro Glu Pro Glu Glu Glu 
        35                  40                  45              


Ile Leu Gly Ser Asp Asp Glu Glu Gln Glu Asp Pro Ala Asp Tyr Cys 
    50                  55                  60                  


Lys Gly Gly Tyr His Pro Val Lys Ile Gly Asp Leu Phe Asn Gly Arg 
65                  70                  75                  80  


Tyr His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp 
                85                  90                  95      


Leu Cys Trp Asp Met Gln Gly Lys Arg Phe Val Ala Met Lys Val Val 
            100                 105                 110         


Lys Ser Ala Gln His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Lys Leu 
        115                 120                 125             


Leu Lys Cys Val Arg Glu Ser Asp Pro Ser Asp Pro Asn Lys Asp Met 
    130                 135                 140                 


Val Val Gln Leu Ile Asp Asp Phe Lys Ile Ser Gly Met Asn Gly Ile 
145                 150                 155                 160 


<210> 8216
<211> 21
<212> PRT
<213> Homo sapiens

<400> 8216
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr 
            20      


<210> 8217
<211> 403
<212> PRT
<213> Homo sapiens

<400> 8217
Met Ser Gly Ser Asp Gly Gly Leu Glu Glu Glu Pro Glu Leu Ser Ile 
1               5                   10                  15      


Thr Leu Thr Leu Arg Met Leu Met His Gly Lys Glu Val Gly Ser Ile 
            20                  25                  30          


Ile Gly Lys Lys Gly Glu Thr Val Lys Arg Ile Arg Glu Gln Ser Ser 
        35                  40                  45              


Ala Arg Ile Thr Ile Ser Glu Gly Ser Cys Pro Glu Arg Ile Thr Thr 
    50                  55                  60                  


Ile Thr Gly Ser Thr Ala Ala Val Phe His Ala Val Ser Met Ile Ala 
65                  70                  75                  80  


Phe Lys Leu Asp Glu Asp Leu Cys Ala Ala Pro Ala Asn Gly Gly Asn 
                85                  90                  95      


Val Ser Arg Pro Pro Val Thr Leu Arg Leu Val Ile Pro Ala Ser Gln 
            100                 105                 110         


Cys Gly Ser Leu Ile Gly Lys Ala Gly Thr Lys Ile Lys Glu Ile Arg 
        115                 120                 125             


Glu Thr Thr Gly Ala Gln Val Gln Val Ala Gly Asp Leu Leu Pro Asn 
    130                 135                 140                 


Ser Thr Glu Arg Ala Val Thr Val Ser Gly Val Pro Asp Ala Ile Ile 
145                 150                 155                 160 


Leu Cys Val Arg Gln Ile Cys Ala Val Ile Leu Glu Ser Pro Pro Lys 
                165                 170                 175     


Gly Ala Thr Ile Pro Tyr His Pro Ser Leu Ser Leu Gly Thr Val Leu 
            180                 185                 190         


Leu Ser Ala Asn Gln Gly Phe Ser Val Gln Gly Gln Tyr Gly Ala Val 
        195                 200                 205             


Thr Pro Ala Glu Val Thr Lys Leu Gln Gln Leu Ser Ser His Ala Val 
    210                 215                 220                 


Pro Phe Ala Thr Pro Ser Val Val Pro Gly Leu Asp Pro Gly Thr Gln 
225                 230                 235                 240 


Thr Ser Ser Gln Glu Phe Leu Val Pro Asn Asp Leu Ile Gly Cys Val 
                245                 250                 255     


Ile Gly Arg Gln Gly Ser Lys Ile Ser Glu Ile Arg Gln Met Ser Gly 
            260                 265                 270         


Ala His Ile Lys Ile Gly Asn Gln Ala Glu Gly Ala Gly Glu Arg His 
        275                 280                 285             


Val Thr Ile Thr Gly Ser Pro Val Ser Ile Ala Leu Ala Gln Tyr Leu 
    290                 295                 300                 


Ile Thr Ala Cys Leu Glu Thr Ala Lys Ser Thr Ser Gly Gly Thr Pro 
305                 310                 315                 320 


Ser Ser Ala Pro Ala Asp Leu Pro Ala Pro Phe Ser Pro Pro Leu Thr 
                325                 330                 335     


Ala Leu Pro Thr Ala Pro Pro Gly Leu Leu Gly Thr Pro Tyr Ala Ile 
            340                 345                 350         


Ser Leu Ser Asn Phe Ile Gly Leu Lys Pro Met Pro Phe Leu Ala Leu 
        355                 360                 365             


Pro Pro Ala Ser Pro Gly Pro Pro Pro Gly Leu Ala Ala Tyr Thr Ala 
    370                 375                 380                 


Lys Met Ala Ala Ala Asn Gly Ser Lys Lys Ala Glu Arg Gln Lys Phe 
385                 390                 395                 400 


Ser Pro Tyr 
            


<210> 8218
<211> 1701
<212> PRT
<213> Homo sapiens

<400> 8218
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys 
    50                  55                  60                  


Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Pro Thr Cys Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr 
                85                  90                  95      


Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr 
            100                 105                 110         


Glu Asn Gly Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile 
        115                 120                 125             


Thr Ser Arg Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn 
    130                 135                 140                 


Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg 
145                 150                 155                 160 


Val Leu Ile Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu 
                165                 170                 175     


Phe His Asn Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser 
            180                 185                 190         


Glu Pro Val Gln Leu Leu Arg Tyr Ser Pro Thr Leu Ala Ser Glu Thr 
        195                 200                 205             


Ser Pro Val Pro Glu Ala Arg Arg Gly Ser Ser Ala Asp Ser Leu Pro 
    210                 215                 220                 


Ser His Arg Pro Ser Pro Thr Asp Ser Arg Leu Arg Ser Ser Lys Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Ser Glu Ser Ser Trp Tyr Asp Ser Pro Trp Gly Asn 
                245                 250                 255     


Ala Gly Glu Leu Ser Glu Ala Glu Gly Ser Phe Leu Ala Pro Gly Met 
            260                 265                 270         


Pro Asp Pro Ser Leu His Ala Ser Phe Pro Pro Gly Asp Ala Lys Lys 
        275                 280                 285             


Pro Phe Asn Gln Ser Ser Ser Leu Ser Ser Leu Arg Glu Leu Tyr Lys 
    290                 295                 300                 


Asp Ala Asn Leu Gly Ser Leu Ser Pro Ser Gly Ile Arg Leu Ser Asp 
305                 310                 315                 320 


Glu Tyr Met Gly Thr His Ala Ser Leu Ser Asn Arg Val Ser Phe Ala 
                325                 330                 335     


Ser Asp Ile Asp Val Pro Ser Arg Val Ala His Gly Asp Pro Ile Gln 
            340                 345                 350         


Tyr Ser Ser Phe Thr Leu Pro Cys Arg Lys Pro Lys Ala Phe Val Glu 
        355                 360                 365             


Asp Thr Ala Lys Lys Asp Ser Leu Lys Ala Arg Met Arg Arg Ile Ser 
    370                 375                 380                 


Asp Trp Thr Gly Ser Leu Ser Arg Lys Lys Arg Lys Leu Gln Glu Pro 
385                 390                 395                 400 


Arg Ser Lys Glu Gly Ser Asp Tyr Phe Asp Ser Arg Ser Asp Gly Leu 
                405                 410                 415     


Asn Thr Asp Val Gln Gly Ser Ser Gln Ala Ser Ala Phe Leu Trp Ser 
            420                 425                 430         


Gly Gly Ser Thr Gln Ile Leu Ser Gln Arg Ser Glu Ser Thr His Ala 
        435                 440                 445             


Ile Gly Ser Asp Pro Leu Arg Gln Asn Ile Tyr Glu Asn Phe Met Arg 
    450                 455                 460                 


Glu Leu Glu Met Ser Arg Thr Asn Thr Glu Asn Ile Glu Thr Ser Thr 
465                 470                 475                 480 


Glu Thr Ala Glu Ser Ser Ser Glu Ser Leu Ser Ser Leu Glu Gln Leu 
                485                 490                 495     


Asp Leu Leu Phe Glu Lys Glu Gln Gly Val Val Arg Lys Ala Gly Trp 
            500                 505                 510         


Leu Phe Phe Lys Pro Leu Val Thr Val Gln Lys Glu Arg Lys Leu Glu 
        515                 520                 525             


Leu Val Ala Arg Arg Lys Trp Lys Gln Tyr Trp Val Thr Leu Lys Gly 
    530                 535                 540                 


Cys Thr Leu Leu Phe Tyr Glu Thr Tyr Gly Lys Asn Ser Met Asp Gln 
545                 550                 555                 560 


Ser Ser Ala Pro Arg Cys Ala Leu Phe Ala Glu Asp Ser Ile Val Gln 
                565                 570                 575     


Ser Val Pro Glu His Pro Lys Lys Glu Asn Val Phe Cys Leu Ser Asn 
            580                 585                 590         


Ser Phe Gly Asp Val Tyr Leu Phe Gln Ala Thr Ser Gln Thr Asp Leu 
        595                 600                 605             


Glu Asn Trp Val Thr Ala Val His Ser Ala Cys Ala Ser Leu Phe Ala 
    610                 615                 620                 


Lys Lys His Gly Lys Glu Asp Thr Leu Arg Leu Leu Lys Asn Gln Thr 
625                 630                 635                 640 


Lys Asn Leu Leu Gln Lys Ile Asp Met Asp Ser Lys Met Lys Lys Met 
                645                 650                 655     


Ala Glu Leu Gln Leu Ser Val Val Ser Asp Pro Lys Asn Arg Lys Ala 
            660                 665                 670         


Ile Glu Asn Gln Ile Gln Gln Trp Glu Gln Asn Leu Glu Lys Phe His 
        675                 680                 685             


Met Asp Leu Phe Arg Met Arg Cys Tyr Leu Ala Ser Leu Gln Gly Gly 
    690                 695                 700                 


Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala Ala Ala Ser Arg Pro Ser 
705                 710                 715                 720 


Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu Ser Val Ser Ser Phe His 
                725                 730                 735     


Ala Leu Val Cys Ser Arg Asp Asp Ser Ala Leu Arg Lys Arg Thr Leu 
            740                 745                 750         


Ser Leu Thr Gln Arg Gly Arg Asn Lys Lys Gly Ile Phe Ser Ser Leu 
        755                 760                 765             


Lys Gly Leu Asp Thr Leu Ala Arg Lys Gly Lys Glu Lys Arg Pro Ser 
    770                 775                 780                 


Ile Thr Gln Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp 
785                 790                 795                 800 


Gly Val Pro Arg Asp Asn Ala Trp Glu Ile Gln Thr Tyr Val His Phe 
                805                 810                 815     


Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val 
            820                 825                 830         


Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser 
        835                 840                 845             


His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr 
    850                 855                 860                 


Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu 
865                 870                 875                 880 


Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr 
                885                 890                 895     


Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu 
            900                 905                 910         


Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly 
        915                 920                 925             


Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu 
    930                 935                 940                 


Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu 
945                 950                 955                 960 


Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp 
                965                 970                 975     


Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser 
            980                 985                 990         


Arg Asp Gln Lys Ser Leu Leu Pro  Pro Pro Asn Gln Ser  Gln Leu Leu 
        995                 1000                 1005             


Glu Glu  Phe Leu Asp Asn Phe  Lys Lys Asn Thr Ala  Asn Asp Phe 
    1010                 1015                 1020             


Ser Asn  Val Pro Asp Ile Thr  Thr Gly Leu Lys Arg  Ser Gln Thr 
    1025                 1030                 1035             


Asp Gly  Thr Leu Asp Gln Val  Ser His Arg Glu Lys  Met Glu Gln 
    1040                 1045                 1050             


Thr Phe  Arg Ser Ala Glu Gln  Ile Thr Ala Leu Cys  Arg Ser Phe 
    1055                 1060                 1065             


Asn Asp  Ser Gln Ala Asn Gly  Met Glu Gly Pro Arg  Glu Asn Gln 
    1070                 1075                 1080             


Asp Pro  Pro Pro Arg Ser Leu  Ala Arg His Leu Ser  Asp Ala Asp 
    1085                 1090                 1095             


Arg Leu  Arg Lys Val Ile Gln  Glu Leu Val Asp Thr  Glu Lys Ser 
    1100                 1105                 1110             


Tyr Val  Lys Asp Leu Ser Cys  Leu Phe Glu Leu Tyr  Leu Glu Pro 
    1115                 1120                 1125             


Leu Gln  Asn Glu Thr Phe Leu  Thr Gln Asp Glu Met  Glu Ser Leu 
    1130                 1135                 1140             


Phe Gly  Ser Leu Pro Glu Met  Leu Glu Phe Gln Lys  Val Phe Leu 
    1145                 1150                 1155             


Glu Thr  Leu Glu Asp Gly Ile  Ser Ala Ser Ser Asp  Phe Asn Thr 
    1160                 1165                 1170             


Leu Glu  Thr Pro Ser Gln Phe  Arg Lys Leu Leu Phe  Ser Leu Gly 
    1175                 1180                 1185             


Gly Ser  Phe Leu Tyr Tyr Ala  Asp His Phe Lys Leu  Tyr Ser Gly 
    1190                 1195                 1200             


Phe Cys  Ala Asn His Ile Lys  Val Gln Lys Val Leu  Glu Arg Ala 
    1205                 1210                 1215             


Lys Thr  Asp Lys Ala Phe Lys  Ala Phe Leu Asp Ala  Arg Asn Pro 
    1220                 1225                 1230             


Thr Lys  Gln His Ser Ser Thr  Leu Glu Ser Tyr Leu  Ile Lys Pro 
    1235                 1240                 1245             


Val Gln  Arg Val Leu Lys Tyr  Pro Leu Leu Leu Lys  Glu Leu Val 
    1250                 1255                 1260             


Ser Leu  Thr Asp Gln Glu Ser  Glu Glu His Tyr His  Leu Thr Glu 
    1265                 1270                 1275             


Ala Leu  Lys Ala Met Glu Lys  Val Ala Ser His Ile  Asn Glu Met 
    1280                 1285                 1290             


Gln Lys  Ile Tyr Glu Asp Tyr  Gly Thr Val Phe Asp  Gln Leu Val 
    1295                 1300                 1305             


Ala Glu  Gln Ser Gly Thr Glu  Lys Glu Val Thr Glu  Leu Ser Met 
    1310                 1315                 1320             


Gly Glu  Leu Leu Met His Ser  Thr Val Ser Trp Leu  Asn Pro Phe 
    1325                 1330                 1335             


Leu Ser  Leu Gly Lys Ala Arg  Lys Asp Leu Glu Leu  Thr Val Phe 
    1340                 1345                 1350             


Val Phe  Lys Arg Ala Val Ile  Leu Val Tyr Lys Glu  Asn Cys Lys 
    1355                 1360                 1365             


Leu Lys  Lys Lys Leu Pro Ser  Asn Ser Arg Pro Ala  His Asn Ser 
    1370                 1375                 1380             


Thr Asp  Leu Asp Pro Phe Lys  Phe Arg Trp Leu Ile  Pro Ile Ser 
    1385                 1390                 1395             


Ala Leu  Gln Val Arg Leu Gly  Asn Pro Ala Gly Thr  Glu Asn Asn 
    1400                 1405                 1410             


Ser Ile  Trp Glu Leu Ile His  Thr Lys Ser Glu Ile  Glu Gly Arg 
    1415                 1420                 1425             


Pro Glu  Thr Ile Phe Gln Leu  Cys Cys Ser Asp Ser  Glu Ser Lys 
    1430                 1435                 1440             


Thr Asn  Ile Val Lys Val Ile  Arg Ser Ile Leu Arg  Glu Asn Phe 
    1445                 1450                 1455             


Arg Arg  His Ile Lys Cys Glu  Leu Pro Leu Glu Lys  Thr Cys Lys 
    1460                 1465                 1470             


Asp Arg  Leu Val Pro Leu Lys  Asn Arg Val Pro Val  Ser Ala Lys 
    1475                 1480                 1485             


Leu Ala  Ser Ser Arg Ser Leu  Lys Val Leu Lys Asn  Ser Ser Ser 
    1490                 1495                 1500             


Asn Glu  Trp Thr Gly Glu Thr  Gly Lys Gly Thr Leu  Leu Asp Ser 
    1505                 1510                 1515             


Asp Glu  Gly Ser Leu Ser Ser  Gly Thr Gln Ser Ser  Gly Cys Pro 
    1520                 1525                 1530             


Thr Ala  Glu Gly Arg Gln Asp  Ser Lys Ser Thr Ser  Pro Gly Lys 
    1535                 1540                 1545             


Tyr Pro  His Pro Gly Leu Ala  Asp Phe Ala Asp Asn  Leu Ile Lys 
    1550                 1555                 1560             


Glu Ser  Asp Ile Leu Ser Asp  Glu Asp Asp Asp His  Arg Gln Thr 
    1565                 1570                 1575             


Val Lys  Gln Gly Ser Pro Thr  Lys Asp Ile Glu Ile  Gln Phe Gln 
    1580                 1585                 1590             


Arg Leu  Arg Ile Ser Glu Asp  Pro Asp Val His Pro  Glu Ala Glu 
    1595                 1600                 1605             


Gln Gln  Pro Gly Pro Glu Ser  Gly Glu Gly Gln Lys  Gly Gly Glu 
    1610                 1615                 1620             


Gln Pro  Lys Leu Val Arg Gly  His Phe Cys Pro Ile  Lys Arg Lys 
    1625                 1630                 1635             


Ala Asn  Ser Thr Lys Arg Asp  Arg Gly Thr Leu Leu  Lys Ala Gln 
    1640                 1645                 1650             


Ile Arg  His Gln Ser Leu Asp  Ser Gln Ser Glu Asn  Ala Thr Ile 
    1655                 1660                 1665             


Asp Leu  Asn Ser Val Leu Glu  Arg Glu Phe Ser Val  Gln Ser Leu 
    1670                 1675                 1680             


Thr Ser  Val Val Ser Glu Glu  Cys Phe Tyr Glu Thr  Glu Ser His 
    1685                 1690                 1695             


Gly Lys  Ser 
    1700     


<210> 8219
<211> 135
<212> PRT
<213> Homo sapiens

<400> 8219
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Thr Ile Val Val Leu Gly Asn 
    50                  55                  60                  


Lys Cys Asp Leu Gln Glu Gln Arg Arg Val Asp Pro Asp Val Ala Gln 
65                  70                  75                  80  


His Trp Ala Lys Ser Glu Lys Val Lys Leu Trp Glu Val Ser Val Ala 
                85                  90                  95      


Asp Arg Arg Ser Leu Leu Glu Pro Phe Val Tyr Leu Ala Ser Lys Met 
            100                 105                 110         


Thr Gln Pro Gln Ser Lys Ser Ala Phe Pro Leu Ser Arg Lys Asn Lys 
        115                 120                 125             


Gly Ser Gly Ser Leu Asp Gly 
    130                 135 


<210> 8220
<211> 1230
<212> PRT
<213> Homo sapiens

<400> 8220
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu 
                165                 170                 175     


Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp 
            180                 185                 190         


Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp 
        195                 200                 205             


Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg 
    210                 215                 220                 


Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro 
225                 230                 235                 240 


Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp 
                245                 250                 255     


Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg 
            260                 265                 270         


Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Leu Asn Arg Val 
        275                 280                 285             


Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn Ile 
    290                 295                 300                 


Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys Asn 
305                 310                 315                 320 


His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala Glu 
                325                 330                 335     


Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile Asn 
            340                 345                 350         


Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys Asp 
        355                 360                 365             


Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile Glu 
    370                 375                 380                 


Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln Val 
385                 390                 395                 400 


Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Lys Leu Glu Lys 
                405                 410                 415     


Gln Leu Gln Lys Asp Lys Glu Lys Val Glu Glu Phe Lys Ser Ile Pro 
            420                 425                 430         


Ala Lys Ser Asn Asn Ile Ile Asn Glu Thr Thr Thr Arg Asn Asn Ala 
        435                 440                 445             


Leu Glu Lys Glu Lys Glu Lys Glu Glu Lys Lys Leu Lys Glu Val Met 
    450                 455                 460                 


Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu Ser 
465                 470                 475                 480 


Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala Arg 
                485                 490                 495     


Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser Arg 
            500                 505                 510         


His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu Ile 
        515                 520                 525             


Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp Ile 
    530                 535                 540                 


Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu Val 
                565                 570                 575     


His Asp Leu Phe Gln Lys Val Glu Glu Ala Lys Ser Ser Leu Ala Met 
            580                 585                 590         


Asn Arg Ser Arg Gly Lys Val Leu Asp Ala Ile Ile Gln Glu Lys Lys 
        595                 600                 605             


Ser Gly Arg Ile Pro Gly Ile Tyr Gly Arg Leu Gly Asp Leu Gly Ala 
    610                 615                 620                 


Ile Asp Glu Lys Tyr Asp Val Ala Ile Ser Ser Cys Cys His Ala Leu 
625                 630                 635                 640 


Asp Tyr Ile Val Val Asp Ser Ile Asp Ile Ala Gln Glu Cys Val Asn 
                645                 650                 655     


Phe Leu Lys Arg Gln Asn Ile Gly Val Ala Thr Phe Ile Gly Leu Asp 
            660                 665                 670         


Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro Glu 
        675                 680                 685             


Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys Ile 
    690                 695                 700                 


Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp Asn 
705                 710                 715                 720 


Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp Arg 
                725                 730                 735     


Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met Thr 
            740                 745                 750         


Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu Val 
        755                 760                 765             


Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu Gln 
    770                 775                 780                 


Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln Leu 
785                 790                 795                 800 


Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg Asn 
                805                 810                 815     


Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln Glu 
            820                 825                 830         


Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu Ala 
        835                 840                 845             


Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val Ser 
    850                 855                 860                 


Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Gly Lys Val 
865                 870                 875                 880 


Glu Ala Glu Val Lys Arg Leu His Asn Thr Ile Val Glu Ile Asn Asn 
                885                 890                 895     


His Lys Leu Lys Ala Gln Gln Asp Lys Leu Asp Lys Ile Asn Lys Gln 
            900                 905                 910         


Leu Asp Glu Cys Ala Ser Ala Ile Thr Lys Ala Gln Val Ala Ile Lys 
        915                 920                 925             


Thr Ala Asp Arg Asn Leu Gln Lys Ala Gln Asp Ser Val Leu Arg Thr 
    930                 935                 940                 


Glu Lys Glu Ile Lys Asp Thr Glu Lys Glu Val Asp Asp Leu Thr Ala 
945                 950                 955                 960 


Glu Leu Lys Ser Leu Glu Asp Lys Ala Ala Glu Val Val Lys Asn Thr 
                965                 970                 975     


Asn Ala Ala Glu Ile Ser Lys Ile Ser Leu His Pro Ile Glu Asp Asn 
            980                 985                 990         


Pro Ile Glu Glu Ile Ser Val Leu  Ser Pro Glu Asp Leu  Glu Ala Ile 
        995                 1000                 1005             


Lys Asn  Pro Asp Ser Ile Thr  Asn Gln Ile Ala Leu  Leu Glu Ala 
    1010                 1015                 1020             


Arg Cys  His Glu Met Lys Pro  Asn Leu Gly Ala Ile  Ala Glu Tyr 
    1025                 1030                 1035             


Lys Lys  Lys Glu Glu Leu Tyr  Leu Gln Arg Val Ala  Glu Leu Asp 
    1040                 1045                 1050             


Lys Ile  Thr Tyr Glu Arg Asp  Ser Phe Arg Gln Ala  Tyr Glu Asp 
    1055                 1060                 1065             


Leu Arg  Lys Gln Arg Leu Asn  Glu Phe Met Ala Gly  Phe Tyr Ile 
    1070                 1075                 1080             


Ile Thr  Asn Lys Leu Lys Glu  Asn Tyr Gln Met Leu  Thr Leu Gly 
    1085                 1090                 1095             


Gly Asp  Ala Glu Leu Glu Leu  Val Asp Ser Leu Asp  Pro Phe Ser 
    1100                 1105                 1110             


Glu Gly  Ile Met Phe Ser Val  Arg Pro Pro Lys Lys  Ser Trp Lys 
    1115                 1120                 1125             


Lys Ile  Phe Asn Leu Ser Gly  Gly Glu Lys Thr Leu  Ser Ser Leu 
    1130                 1135                 1140             


Ala Leu  Val Phe Ala Leu His  His Tyr Lys Pro Thr  Pro Leu Tyr 
    1145                 1150                 1155             


Phe Met  Asp Glu Ile Asp Ala  Ala Leu Asp Phe Lys  Asn Val Ser 
    1160                 1165                 1170             


Ile Val  Ala Phe Tyr Ile Tyr  Glu Gln Thr Lys Asn  Ala Gln Phe 
    1175                 1180                 1185             


Ile Ile  Ile Ser Leu Arg Asn  Asn Met Phe Glu Ile  Ser Asp Arg 
    1190                 1195                 1200             


Leu Ile  Gly Ile Tyr Lys Thr  Tyr Asn Ile Thr Lys  Ser Val Ala 
    1205                 1210                 1215             


Val Asn  Pro Lys Glu Ile Ala  Ser Lys Gly Leu Cys  
    1220                 1225                 1230 


<210> 8221
<211> 88
<212> PRT
<213> Homo sapiens

<400> 8221
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu 
                85              


<210> 8222
<211> 1208
<212> PRT
<213> Homo sapiens

<400> 8222
Met Asp Ser Leu Pro Asp Glu Phe Phe Val Arg His Pro Ala Val Glu 
1               5                   10                  15      


Asp Gln Arg Lys Glu Glu Thr Glu Asn Lys Leu Glu Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Asn Lys Gln Glu Asn Asp Ile Pro Thr Asp Leu Val Pro Val 
        35                  40                  45              


Asn Leu Leu Leu Glu Val Lys Lys Leu Leu Asn Ala Ile Asn Thr Leu 
    50                  55                  60                  


Pro Lys Gly Val Val Pro His Ile Lys Lys Phe Leu Gln Glu Asp Phe 
65                  70                  75                  80  


Ser Phe Gln Thr Met Gln Arg Glu Val Ala Ala Asn Ser Gln Asn Gly 
                85                  90                  95      


Glu Glu Ile Val Pro Ala Leu Thr Leu Arg Phe Leu Ile Thr Gln Leu 
            100                 105                 110         


Glu Ala Ala Leu Arg Asn Ile Gln Ala Gly Asn Tyr Thr Ala His Gln 
        115                 120                 125             


Ile Asn Ile Gly Tyr Tyr Leu Thr Leu Leu Phe Leu Tyr Gly Val Ala 
    130                 135                 140                 


Leu Thr Glu Arg Gly Lys Lys Glu Asp Tyr Thr Glu Ala Glu Asn Lys 
145                 150                 155                 160 


Phe Leu Val Met Lys Met Met Ile Gln Glu Asn Glu Ile Cys Glu Asn 
                165                 170                 175     


Phe Met Ser Leu Val Tyr Phe Gly Arg Gly Leu Leu Arg Cys Ala Gln 
            180                 185                 190         


Lys Arg Tyr Asn Gly Gly Leu Leu Glu Phe His Lys Ser Leu Gln Glu 
        195                 200                 205             


Ile Gly Asp Lys Asn Asp His Trp Phe Asp Ile Asp Pro Thr Glu Asp 
    210                 215                 220                 


Glu Asp Leu Pro Thr Thr Phe Lys Asp Leu Leu Asn Asn Phe Ile Lys 
225                 230                 235                 240 


Thr Thr Glu Ser Asn Ile Met Lys Gln Thr Ile Cys Ser Tyr Leu Asp 
                245                 250                 255     


Cys Glu Arg Ser Cys Glu Ala Asp Ile Leu Lys Asn Thr Ser Tyr Lys 
            260                 265                 270         


Gly Phe Phe Gln Leu Met Cys Ser Lys Ser Cys Cys Val Tyr Phe His 
        275                 280                 285             


Lys Ile Cys Trp Lys Lys Phe Lys Asn Leu Lys Tyr Pro Gly Glu Asn 
    290                 295                 300                 


Asp Gln Ser Phe Ser Gly Lys Lys Cys Leu Lys Glu Gly Cys Thr Gly 
305                 310                 315                 320 


Asp Met Val Arg Met Leu Gln Cys Asp Val Pro Gly Ile Val Lys Ile 
                325                 330                 335     


Leu Phe Glu Val Val Arg Lys Asp Glu Tyr Ile Thr Ile Glu Asn Leu 
            340                 345                 350         


Gly Ala Ser Tyr Arg Lys Leu Ile Ser Leu Lys Ile Thr Asp Thr Asp 
        355                 360                 365             


Ile Arg Pro Lys Ile Ser Leu Lys Phe Asn Thr Lys Asp Glu Met Pro 
    370                 375                 380                 


Ile Phe Lys Leu Asp Tyr Asn Tyr Phe Tyr His Leu Leu His Ile Ile 
385                 390                 395                 400 


Ile Ile Ser Gly Thr Asp Ile Val Arg Gln Ile Phe Asp Glu Ala Met 
                405                 410                 415     


Pro Pro Pro Leu Leu Lys Lys Glu Leu Leu Ile His Lys Asn Val Leu 
            420                 425                 430         


Glu Ser Tyr Tyr Asn His Leu Trp Thr Asn His Pro Leu Gly Gly Ser 
        435                 440                 445             


Trp His Leu Leu Tyr Pro Pro Asn Lys Glu Leu Pro Gln Ser Lys Gln 
    450                 455                 460                 


Phe Asp Leu Cys Leu Leu Leu Ala Leu Ile Lys His Leu Asn Val Phe 
465                 470                 475                 480 


Pro Ala Pro Lys Lys Gly Trp Asn Met Glu Pro Pro Ser Ser Asp Ile 
                485                 490                 495     


Ser Lys Ser Ala Asp Ile Leu Arg Leu Cys Lys Tyr Arg Asp Ile Leu 
            500                 505                 510         


Leu Ser Glu Ile Leu Met Asn Gly Leu Thr Glu Ser Gln Phe Asn Ser 
        515                 520                 525             


Ile Trp Lys Lys Val Ser Asp Ile Leu Leu Arg Leu Gly Met Met Gln 
    530                 535                 540                 


Glu Asp Ile Asp Lys Val Lys Glu Asn Pro Ile Glu Asn Ile Ser Leu 
545                 550                 555                 560 


Asp Tyr His Gln Leu Ser Val Tyr Leu Gly Ile Pro Val Pro Glu Ile 
                565                 570                 575     


Ile Gln Arg Met Leu Ser Cys Tyr Gln Gln Gly Ile Ala Leu Gln Ser 
            580                 585                 590         


Ile Thr Gly Ser Gln Arg Ile Glu Ile Glu Glu Leu Gln Asn Glu Glu 
        595                 600                 605             


Glu Glu Leu Ser Pro Pro Leu Met Glu Tyr Asn Ile Asn Val Lys Ser 
    610                 615                 620                 


His Pro Glu Ile Gln Phe Ala Glu Ile Asn Lys Asp Gly Thr Ser Ile 
625                 630                 635                 640 


Pro Ser Glu Ser Ser Thr Glu Ser Leu Lys Asp Leu Gln Glu Val Lys 
                645                 650                 655     


Ser Lys Gln Arg Lys Lys Lys Lys Thr Lys Asn Lys Lys Asn Lys Asp 
            660                 665                 670         


Ser Lys Glu Asp Gln Val Pro Tyr Val Val Glu Lys Glu Glu Gln Leu 
        675                 680                 685             


Arg Lys Glu Gln Ala Asn Pro His Ser Val Ser Arg Leu Ile Lys Asp 
    690                 695                 700                 


Asp Ala Ser Asp Val Gln Glu Asp Ser Ala Met Glu Asp Lys Phe Tyr 
705                 710                 715                 720 


Ser Leu Asp Glu Leu His Ile Leu Asp Met Ile Glu Gln Gly Ser Ala 
                725                 730                 735     


Gly Lys Val Thr Thr Asp Tyr Gly Glu Thr Glu Lys Glu Arg Leu Ala 
            740                 745                 750         


Arg Gln Arg Gln Leu Tyr Lys Leu His Tyr Gln Cys Glu Asp Phe Lys 
        755                 760                 765             


Arg Gln Leu Arg Thr Val Thr Phe Arg Trp Gln Glu Asn Gln Met Gln 
    770                 775                 780                 


Ile Lys Lys Lys Asp Lys Ile Ile Ala Ser Leu Asn Gln Gln Val Ala 
785                 790                 795                 800 


Phe Gly Ile Asn Lys Val Ser Lys Leu Gln Arg Gln Ile His Ala Lys 
                805                 810                 815     


Asp Asn Glu Ile Lys Asn Leu Lys Glu Gln Leu Ser Met Lys Arg Ser 
            820                 825                 830         


Gln Trp Glu Met Glu Lys His Asn Leu Glu Ser Thr Met Lys Thr Tyr 
        835                 840                 845             


Val Ser Lys Leu Asn Ala Glu Thr Ser Arg Ala Leu Thr Ala Glu Val 
    850                 855                 860                 


Tyr Phe Leu Gln Cys Arg Arg Asp Phe Gly Leu Leu His Leu Glu Gln 
865                 870                 875                 880 


Thr Glu Lys Glu Cys Leu Asn Gln Leu Ala Arg Val Thr His Met Ala 
                885                 890                 895     


Ala Ser Asn Leu Glu Ser Leu Gln Leu Lys Ala Ala Val Asp Ser Trp 
            900                 905                 910         


Asn Ala Ile Val Ala Asp Val Arg Asn Lys Ile Ala Phe Leu Arg Thr 
        915                 920                 925             


Gln Tyr Asn Glu Gln Ile Asn Lys Val Lys Gln Gly Phe Ala Leu Ser 
    930                 935                 940                 


Thr Leu Pro Pro Val Gln Leu Pro Pro Pro Pro Pro Ser Pro Glu Ile 
945                 950                 955                 960 


Leu Met Gln Gln Phe Leu Gly Arg Pro Leu Val Lys Glu Ser Phe Phe 
                965                 970                 975     


Arg Pro Ile Leu Thr Val Pro Gln Met Pro Ala Val Cys Pro Gly Val 
            980                 985                 990         


Val Ser Ala Thr Gly Gln Pro Arg  Ala Pro Leu Met Thr  Gly Ile Ala 
        995                 1000                 1005             


Trp Ala  Leu Pro Ala Pro Val  Gly Asp Ala Val Pro  Pro Ser Ala 
    1010                 1015                 1020             


Gly Leu  Arg Ser Asp Pro Ser  Ile Met Asn Trp Glu  Arg Ile Thr 
    1025                 1030                 1035             


Asp Arg  Leu Lys Thr Ala Phe  Pro Gln Gln Thr Arg  Lys Glu Leu 
    1040                 1045                 1050             


Thr Asp  Phe Leu Arg Lys Leu  Lys Asp Ala Tyr Gly  Lys Ser Leu 
    1055                 1060                 1065             


Ser Glu  Leu Thr Phe Asp Glu  Ile Val Cys Lys Ile  Ser Gln Phe 
    1070                 1075                 1080             


Ile Asp  Pro Lys Lys Ser Gln  Ser Gln Gly Lys Ser  Val Ser Asn 
    1085                 1090                 1095             


Val Asn  Cys Val Ser Pro Ser  His Ser Pro Ser Gln  Pro Asp Ala 
    1100                 1105                 1110             


Ala Gln  Pro Pro Lys Pro Ala  Trp Arg Pro Leu Thr  Ser Gln Gly 
    1115                 1120                 1125             


Pro Ala  Thr Trp Glu Gly Ala  Ser Asn Pro Asp Glu  Glu Glu Glu 
    1130                 1135                 1140             


Glu Glu  Glu Pro Cys Val Ile  Cys His Glu Asn Leu  Ser Pro Glu 
    1145                 1150                 1155             


Asn Leu  Ser Val Leu Pro Cys  Ala His Lys Phe His  Ala Gln Cys 
    1160                 1165                 1170             


Ile Arg  Pro Trp Leu Met Gln  Gln Gly Thr Cys Pro  Thr Cys Arg 
    1175                 1180                 1185             


Leu His  Val Leu Leu Pro Glu  Glu Phe Pro Gly His  Pro Ser Arg 
    1190                 1195                 1200             


Gln Leu  Pro Lys Ile 
    1205             


<210> 8223
<211> 580
<212> PRT
<213> Homo sapiens

<400> 8223
Met Val Leu Val Gly Thr Gln Asp Ala Ile Ser Ala Ala Asn Pro Arg 
1               5                   10                  15      


Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Thr Asp Leu Lys Arg 
            20                  25                  30          


Cys Thr Tyr Tyr Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg 
        35                  40                  45              


Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu Arg Lys Lys Gln 
    50                  55                  60                  


Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His 
65                  70                  75                  80  


Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His Ile Asn Gln Ala 
                85                  90                  95      


Thr Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser Ser Ser Val Pro 
            100                 105                 110         


Ser Thr Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile Glu Thr Ile Ala 
        115                 120                 125             


Ala Ser Ser Thr Pro Thr Pro Ile Arg Lys Gln Ser Lys Arg Arg Ser 
    130                 135                 140                 


Asn Ile Phe Thr Ser Arg Lys Gly Ala Asp Leu Asp Arg Glu Lys Lys 
145                 150                 155                 160 


Ala Ala Glu Cys Lys Val Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro 
                165                 170                 175     


Ile Lys Gln Gly Ile Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys 
            180                 185                 190         


Glu Trp Lys Lys Lys Tyr Val Thr Leu Cys Asp Asn Gly Leu Leu Thr 
        195                 200                 205             


Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Ile His Gly Lys Glu 
    210                 215                 220                 


Ile Asp Leu Leu Arg Thr Thr Val Lys Val Pro Gly Lys Arg Leu Pro 
225                 230                 235                 240 


Arg Ala Thr Pro Ala Thr Ala Pro Gly Thr Ser Pro Arg Ala Asn Gly 
                245                 250                 255     


Leu Ser Val Glu Arg Ser Asn Thr Gln Leu Gly Gly Gly Thr Glu Ala 
            260                 265                 270         


Glu Glu Ser Phe Glu Phe Val Val Val Ser Leu Thr Gly Gln Thr Trp 
        275                 280                 285             


His Phe Glu Ala Ser Thr Ala Glu Glu Arg Glu Leu Trp Val Gln Ser 
    290                 295                 300                 


Val Gln Ala Gln Ile Leu Ala Ser Leu Gln Gly Cys Arg Ser Ala Lys 
305                 310                 315                 320 


Asp Lys Thr Arg Leu Gly Asn Gln Asn Ala Ala Leu Ala Val Gln Ala 
                325                 330                 335     


Val Arg Thr Val Arg Gly Asn Ser Phe Cys Ile Asp Cys Asp Ala Pro 
            340                 345                 350         


Asn Pro Asp Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile Glu 
        355                 360                 365             


Cys Ser Gly Ile His Arg His Leu Gly Ala His Leu Ser Arg Val Arg 
    370                 375                 380                 


Ser Leu Asp Leu Asp Asp Trp Pro Pro Glu Leu Leu Ala Val Met Thr 
385                 390                 395                 400 


Ala Met Gly Asn Ala Leu Ala Asn Ser Val Trp Glu Gly Ala Leu Gly 
                405                 410                 415     


Gly Tyr Ser Lys Pro Gly Pro Asp Ala Cys Arg Glu Glu Lys Glu Arg 
            420                 425                 430         


Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro 
        435                 440                 445             


Ser Ser Asp Val Pro Leu Gly Gln Gln Leu Leu Arg Ala Val Val Glu 
    450                 455                 460                 


Asp Asp Leu Arg Leu Leu Val Met Leu Leu Ala His Gly Ser Lys Glu 
465                 470                 475                 480 


Glu Val Asn Glu Thr Tyr Gly Asp Gly Asp Gly Arg Thr Ala Leu His 
                485                 490                 495     


Leu Ser Ser Ala Met Ala Asn Val Val Phe Thr Gln Leu Leu Ile Trp 
            500                 505                 510         


Tyr Gly Val Asp Val Arg Ser Arg Asp Ala Arg Gly Leu Thr Pro Leu 
        515                 520                 525             


Ala Tyr Ala Arg Arg Ala Gly Ser Gln Glu Cys Ala Asp Ile Leu Ile 
    530                 535                 540                 


Gln His Gly Cys Pro Gly Glu Gly Cys Gly Leu Ala Pro Thr Pro Asn 
545                 550                 555                 560 


Arg Glu Pro Ala Asn Gly Thr Asn Pro Ser Ala Glu Leu His Arg Ser 
                565                 570                 575     


Pro Ser Leu Leu 
            580 


<210> 8224
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8224
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Phe Leu Arg Thr Ile Pro Asp Pro Gly 
                85                  90                  95      


Asp Val Pro Asp Ser Phe Phe 
            100             


<210> 8225
<211> 150
<212> PRT
<213> Homo sapiens

<400> 8225
Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys 
            20                  25                  30          


Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys 
        35                  40                  45              


Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly 
65                  70                  75                  80  


Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe 
                85                  90                  95      


Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro 
            100                 105                 110         


Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp 
        115                 120                 125             


Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr 
    130                 135                 140                 


Ser Lys Asn Asn Ile Pro 
145                 150 


<210> 8226
<211> 179
<212> PRT
<213> Homo sapiens

<400> 8226
Met Thr Asp Leu Val Ala Val Trp Asp Val Ala Leu Ser Asp Gly Val 
1               5                   10                  15      


His Lys Ile Glu Phe Glu His Gly Thr Thr Ser Gly Lys Arg Val Val 
            20                  25                  30          


Tyr Val Asp Gly Lys Glu Glu Ile Arg Lys Glu Trp Met Phe Lys Leu 
        35                  40                  45              


Val Gly Lys Glu Thr Phe Tyr Val Gly Ala Ala Lys Thr Lys Ala Thr 
    50                  55                  60                  


Ile Asn Ile Asp Ala Ile Ser Gly Phe Ala Tyr Glu Tyr Thr Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Lys Ser Leu Lys Lys Tyr Met Glu Asp Arg Ser Lys Thr 
                85                  90                  95      


Thr Asn Thr Trp Val Leu His Met Asp Gly Glu Asn Phe Arg Ile Val 
            100                 105                 110         


Leu Glu Lys Asp Ala Met Asp Val Trp Cys Asn Gly Lys Lys Leu Glu 
        115                 120                 125             


Thr Ala Gly Glu Phe Val Asp Asp Gly Thr Glu Thr His Phe Ser Ile 
    130                 135                 140                 


Gly Asn His Asp Cys Tyr Ile Lys Ala Val Ser Ser Gly Lys Arg Lys 
145                 150                 155                 160 


Glu Gly Ile Ile His Thr Leu Ile Val Asp Asn Arg Glu Ile Pro Glu 
                165                 170                 175     


Ile Ala Ser 
            


<210> 8227
<211> 56
<212> PRT
<213> Homo sapiens

<400> 8227
Met Asp Ser Ser Ile His Leu Ser Ser Leu Ile Ser Arg His Asp Asp 
1               5                   10                  15      


Glu Ala Thr Arg Thr Ser Thr Ser Glu Gly Leu Glu Glu Gly Glu Val 
            20                  25                  30          


Glu Gly Glu Thr Leu Leu Ile Val Glu Ser Glu Asp Gln Ala Ser Val 
        35                  40                  45              


Asp Leu Ser His Asp Gln Ser Gly 
    50                  55      


<210> 8228
<211> 50
<212> PRT
<213> Homo sapiens

<400> 8228
Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp Asp 
1               5                   10                  15      


Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala Tyr Tyr Thr Arg 
            20                  25                  30          


His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Arg Thr 
    50  


<210> 8229
<211> 400
<212> PRT
<213> Homo sapiens

<400> 8229
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Val Met Asn 
            180                 185                 190         


His Gln His Gln Gln Gln Met Ala Pro Ser Thr Leu Ser Gln Gln Asn 
        195                 200                 205             


His Pro Thr Gln Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala 
    210                 215                 220                 


Leu Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile 
225                 230                 235                 240 


Gln Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg 
                245                 250                 255     


Gln Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Ala Glu Thr Leu 
            260                 265                 270         


Ala Pro Val Gln Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met 
        275                 280                 285             


Arg Ser Ile Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro 
    290                 295                 300                 


Tyr His Ser Arg Glu Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys 
305                 310                 315                 320 


Tyr Ser Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu 
                325                 330                 335     


Met Asp Thr Gly Glu Asn Ala Gly Gln Thr Pro Met Asn Ile Asn Pro 
            340                 345                 350         


Gln Gln Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn 
        355                 360                 365             


Val Asp Leu Gly Thr Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn 
    370                 375                 380                 


Asp Val Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 
385                 390                 395                 400 


<210> 8230
<211> 170
<212> PRT
<213> Homo sapiens

<400> 8230
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys 
                165                 170 


<210> 8231
<211> 167
<212> PRT
<213> Homo sapiens

<400> 8231
Met Glu Lys Ala Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys 
1               5                   10                  15      


His Leu Lys Thr Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser 
            20                  25                  30          


Glu Ser His Leu Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr 
        35                  40                  45              


Glu Leu Glu Ala Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val 
    50                  55                  60                  


Glu Leu Leu Leu Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe 
65                  70                  75                  80  


Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ile Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Glu His Leu Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn 
        115                 120                 125             


Leu Ser Ser Met Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn 
    130                 135                 140                 


Thr Asn Leu Lys Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Phe Gln Ser 
                165         


<210> 8232
<211> 791
<212> PRT
<213> Homo sapiens

<400> 8232
Met Ser Asn Gln Gln Glu Lys Tyr Glu Ala Gln Asn Ile Val Asn Ser 
1               5                   10                  15      


Thr Glu Glu Ser Asp Asp Ala Phe Asp Thr Val Thr Ile Pro Val Pro 
            20                  25                  30          


Ser Glu Glu Pro Gln Glu Ser Asp Gln Thr Glu Glu His Glu Ser Gly 
        35                  40                  45              


Ile Glu Gln Phe Ser Glu Ser His Ala Ile His Val Glu Glu Gln Ser 
    50                  55                  60                  


Asp Gln Ser Phe Ser Ser Leu Glu Pro Asp Asn Glu Gln Leu Met Glu 
65                  70                  75                  80  


Glu Val Ile Ser Pro Arg Gln Val Ser Tyr Thr Pro Gln His His Glu 
                85                  90                  95      


Lys Gln Tyr Ala Met Gln Arg Pro Asn Asp Asp Ser Leu Ala Phe Leu 
            100                 105                 110         


Asp Lys Ile Lys Ser Val Lys Glu Ser Leu Gln Glu Ser Val Glu Asp 
        115                 120                 125             


Ser Leu Ala Thr Val Lys Val Val Leu Ile Pro Val Gly Gln Glu Ile 
    130                 135                 140                 


Val Ile Pro Phe Lys Val Asp Thr Ile Leu Lys Tyr Leu Lys Asp His 
145                 150                 155                 160 


Phe Ser His Leu Leu Gly Ile Pro His Ser Val Leu Gln Ile Arg Tyr 
                165                 170                 175     


Ser Gly Lys Ile Leu Lys Asn Asn Glu Thr Leu Val Gln His Gly Val 
            180                 185                 190         


Lys Pro Gln Glu Ile Val Gln Val Glu Ile Phe Ser Thr Asn Pro Asp 
        195                 200                 205             


Leu Tyr Pro Val Arg Arg Ile Asp Gly Leu Thr Asp Val Ser Gln Ile 
    210                 215                 220                 


Ile Thr Val Thr Val Gln Thr Gly Leu Asp Gln Tyr Gln Gln Val Pro 
225                 230                 235                 240 


Val Glu Ile Val Lys Ser Asp Phe His Lys Pro Phe Leu Gly Gly Phe 
                245                 250                 255     


Arg His Lys Val Thr Gly Val Glu Tyr His Asn Ala Gly Thr Gln Thr 
            260                 265                 270         


Val Pro Lys Arg Ile Pro Glu Arg Leu Ser Ile Phe Cys Arg Asp Thr 
        275                 280                 285             


Gln Thr Val Phe Gln Lys Lys Asn Leu Gln Gln Thr Thr Asn Thr Thr 
    290                 295                 300                 


Ser Thr Gln Met Thr Asn Ile Gly Val Tyr Val Ser Asn Met Thr Asp 
305                 310                 315                 320 


Lys Leu Val Thr Pro Gly Lys Tyr Phe Ser Ala Ala Glu Tyr His Ala 
                325                 330                 335     


Gln Arg Leu Lys Ala Val Ile Val Ile Gln Thr Tyr Tyr Arg Gln Trp 
            340                 345                 350         


His Ala Lys Ile Phe Val Glu Asn Leu Arg Arg Gln Lys Ser Leu Arg 
        355                 360                 365             


Leu Glu Trp Glu Thr Gln Gln Glu Leu Arg Lys Ile Arg Glu Lys Glu 
    370                 375                 380                 


Glu Trp Ile Lys Leu Asp Tyr His Arg Arg His Asn Pro Lys Thr Asn 
385                 390                 395                 400 


Glu Asp Phe Glu Phe Leu Tyr Asn Ala Leu Glu Phe Trp Arg Gln Glu 
                405                 410                 415     


Glu Leu Thr Arg Ile Asn Gln Ser Phe Thr Gly Ala Glu Arg Lys Ala 
            420                 425                 430         


Ala Leu Cys Glu Leu Leu Glu Lys Glu Thr Gln Ile Ile Ala Ser Ile 
        435                 440                 445             


Gly Arg His Arg Tyr Ile Ala Tyr Met Ala Asn Gln Glu Ala Ala Ile 
    450                 455                 460                 


Gln Ala Phe Leu Asp Lys Cys Ser Ala Pro Lys Ile Trp Arg Thr Pro 
465                 470                 475                 480 


Asn Gly Lys Thr Ile Glu Met Asp Thr Gln Phe Thr Ile Arg Ala Arg 
                485                 490                 495     


Glu Leu Gln Asn Ile Tyr Lys Cys Ile Met Leu Lys Asn Ile Ser Gln 
            500                 505                 510         


Asp Glu Arg Leu Asp Val Leu Leu Thr Leu Lys His Thr Val Lys Glu 
        515                 520                 525             


His Glu Cys Lys Leu Thr Gln Glu Ile Leu Glu Leu Ile Asp Arg Glu 
    530                 535                 540                 


Val Asp Leu Met Met Arg Gly Val Lys His His Asn Leu Glu Gly Leu 
545                 550                 555                 560 


Arg Lys Arg Ile Ala Thr Leu Phe Phe His Tyr Ile Lys Thr Pro Leu 
                565                 570                 575     


Phe Asn Pro Glu Val Ala Lys Tyr Leu Lys Val Pro Gln Asp Pro Leu 
            580                 585                 590         


Lys Phe Tyr Lys Lys Ile Tyr Phe Cys His Ser Cys Gln Leu Tyr Leu 
        595                 600                 605             


Pro Ser Thr Glu Phe Ser Val Ser Ser Thr Ser Arg Arg Ile Tyr Arg 
    610                 615                 620                 


Cys Arg Asn Cys Ile Asn Leu Gln Asn Glu Ala Gln Lys Arg Glu Ser 
625                 630                 635                 640 


Phe Leu Lys Tyr Lys Cys Leu Leu Gln Gln Leu Tyr Tyr Thr Glu Ala 
                645                 650                 655     


Asp Tyr Glu Asp Asp Ser Lys Ile Ala Phe Leu Met Gln Leu Gln Asp 
            660                 665                 670         


Ile Gln Tyr Leu Thr Glu Asn Ile Trp Ala Ser Gln Ser Val Leu Ser 
        675                 680                 685             


Ala Cys Asp Asn Leu Ser Asp Leu Val Met Val Arg Trp Asn Lys Ser 
    690                 695                 700                 


Leu Glu Trp Ser Pro Trp Asn Cys Ile Leu Leu Thr Lys Asp Glu Ala 
705                 710                 715                 720 


Ala Ala His Leu Lys Leu Thr Ser Ile Glu Glu Gly Tyr Glu Arg Ser 
                725                 730                 735     


Phe Ile His Lys Ile Lys His Lys His Ile Leu Ala Lys Asn Tyr Phe 
            740                 745                 750         


Ser Gln Val Pro Val Leu Ala Ser Phe Ile Leu Asp Asp Gly Glu Ile 
        755                 760                 765             


Asp Glu Ile Arg Trp Lys Tyr His Ser Asp Thr Thr Pro Lys Ile Ile 
    770                 775                 780                 


Glu Ser Gln Arg Pro Pro His 
785                 790     


<210> 8233
<211> 228
<212> PRT
<213> Homo sapiens

<400> 8233
Met Thr Asp Gln Thr Tyr Cys Asp Arg Leu Val Gln Asp Thr Pro Phe 
1               5                   10                  15      


Leu Thr Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile 
            20                  25                  30          


Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Thr Asn Lys Glu Ala 
        35                  40                  45              


Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp 
    50                  55                  60                  


Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe 
65                  70                  75                  80  


Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro 
                85                  90                  95      


Ser Arg His Ala Leu Arg Lys Phe His Ile Thr Asn His Ala Cys Leu 
            100                 105                 110         


Val Leu Ala Arg Gly Gly His Pro Ser Leu Pro Leu Met Ala Trp Met 
        115                 120                 125             


Ser Ser Met Thr Thr Gln Val Cys Cys Ser Pro Gly Leu Ala Ser Pro 
    130                 135                 140                 


Leu Ala Ser Ala Pro Pro Gln Arg Pro Pro Ser Gly Pro Glu Gly Arg 
145                 150                 155                 160 


Val Trp Gln Ala Gln Ala Val Gln Met Leu Val Ser Val Ser His Phe 
                165                 170                 175     


Leu Pro Leu Pro Pro Ser Leu Ser His Gly Ser Phe His Thr Ala Trp 
            180                 185                 190         


Gly Ile Leu Tyr Val His Ser Cys Pro Ser Phe Ser Asn Leu Ile Pro 
        195                 200                 205             


Arg Gly Ser Leu His Val Cys Val Asp Ser Asn Leu Val Pro Thr Ala 
    210                 215                 220                 


Ala Trp Arg Ser 
225             


<210> 8234
<211> 315
<212> PRT
<213> Homo sapiens

<400> 8234
Met Pro Gly Leu Ser Cys Arg Phe Tyr Gln His Lys Phe Pro Glu Val 
1               5                   10                  15      


Glu Asp Val Val Met Val Asn Val Arg Ser Ile Ala Glu Met Gly Ala 
            20                  25                  30          


Tyr Val Ser Leu Leu Glu Tyr Asn Asn Ile Glu Gly Met Ile Leu Leu 
        35                  40                  45              


Ser Glu Leu Ser Arg Arg Arg Ile Arg Ser Ile Asn Lys Leu Ile Arg 
    50                  55                  60                  


Ile Gly Arg Asn Glu Cys Val Val Val Ile Arg Val Asp Lys Glu Lys 
65                  70                  75                  80  


Gly Tyr Ile Asp Leu Ser Lys Arg Arg Val Ser Pro Glu Glu Ala Ile 
                85                  90                  95      


Lys Cys Glu Asp Lys Phe Thr Lys Ser Lys Thr Val Tyr Ser Ile Leu 
            100                 105                 110         


Arg His Val Ala Glu Val Leu Glu Tyr Thr Lys Asp Glu Gln Leu Glu 
        115                 120                 125             


Ser Leu Phe Gln Arg Thr Ala Trp Val Phe Asp Asp Lys Tyr Lys Arg 
    130                 135                 140                 


Pro Gly Tyr Gly Ala Tyr Asp Ala Phe Lys His Ala Val Ser Asp Pro 
145                 150                 155                 160 


Ser Ile Leu Asp Ser Leu Asp Leu Asn Glu Asp Glu Arg Glu Val Leu 
                165                 170                 175     


Ile Asn Asn Ile Asn Arg Arg Leu Thr Pro Gln Ala Val Lys Ile Arg 
            180                 185                 190         


Ala Asp Ile Glu Val Ala Cys Tyr Gly Tyr Glu Gly Ile Asp Ala Val 
        195                 200                 205             


Lys Glu Ala Leu Arg Ala Gly Leu Asn Cys Ser Thr Glu Asn Met Pro 
    210                 215                 220                 


Ile Lys Ile Asn Leu Ile Ala Pro Pro Arg Tyr Val Met Thr Thr Thr 
225                 230                 235                 240 


Thr Leu Glu Arg Thr Glu Gly Leu Ser Val Leu Ser Gln Ala Met Ala 
                245                 250                 255     


Val Ile Lys Glu Lys Ile Glu Glu Lys Arg Gly Val Phe Asn Val Gln 
            260                 265                 270         


Met Glu Pro Lys Val Val Thr Asp Thr Asp Glu Thr Glu Leu Ala Arg 
        275                 280                 285             


Gln Met Glu Arg Leu Glu Arg Glu Asn Ala Glu Val Asp Gly Asp Asp 
    290                 295                 300                 


Asp Ala Glu Glu Met Glu Ala Lys Ala Glu Asp 
305                 310                 315 


<210> 8235
<211> 400
<212> PRT
<213> Homo sapiens

<400> 8235
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Val Met Asn 
            180                 185                 190         


His Gln His Gln Gln Gln Met Ala Pro Ser Thr Leu Ser Gln Gln Asn 
        195                 200                 205             


His Pro Thr Gln Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala 
    210                 215                 220                 


Leu Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile 
225                 230                 235                 240 


Gln Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg 
                245                 250                 255     


Gln Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Ala Glu Thr Leu 
            260                 265                 270         


Ala Pro Val Gln Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met 
        275                 280                 285             


Arg Ser Ile Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro 
    290                 295                 300                 


Tyr His Ser Arg Glu Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys 
305                 310                 315                 320 


Tyr Ser Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu 
                325                 330                 335     


Met Asp Thr Gly Glu Asn Ala Gly Gln Thr Pro Met Asn Ile Asn Pro 
            340                 345                 350         


Gln Gln Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn 
        355                 360                 365             


Val Asp Leu Gly Thr Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn 
    370                 375                 380                 


Asp Val Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 
385                 390                 395                 400 


<210> 8236
<211> 126
<212> PRT
<213> Homo sapiens

<400> 8236
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met Glu Cys Phe Leu Gln Tyr Val Tyr Thr 
        115                 120                 125     


<210> 8237
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8237
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Phe Leu Arg Thr Ile Pro Asp Pro Gly 
                85                  90                  95      


Asp Val Pro Asp Ser Phe Phe 
            100             


<210> 8238
<211> 78
<212> PRT
<213> Homo sapiens

<400> 8238
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro 
65                  70                  75              


<210> 8239
<211> 439
<212> PRT
<213> Homo sapiens

<400> 8239
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu Gln 
225                 230                 235                 240 


Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Gly Ser Thr Cys 
                245                 250                 255     


Ala Ser Leu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
            260                 265                 270         


Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly 
        275                 280                 285             


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr 
    290                 295                 300                 


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
305                 310                 315                 320 


Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln 
                325                 330                 335     


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe 
            340                 345                 350         


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
        355                 360                 365             


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
    370                 375                 380                 


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser 
385                 390                 395                 400 


Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly 
                405                 410                 415     


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
            420                 425                 430         


Asn Tyr Val Glu Leu Ile Glu 
        435                 


<210> 8240
<211> 72
<212> PRT
<213> Homo sapiens

<400> 8240
Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Ala Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Ser Lys Cys Pro Gln Ser Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210> 8241
<211> 113
<212> PRT
<213> Homo sapiens

<400> 8241
Met Ser Ala Ile Gln Asn Leu His Ser Phe Asp Pro Phe Ala Asp Ala 
1               5                   10                  15      


Ser Lys Gly Asp Asp Leu Leu Pro Ala Gly Thr Glu Asp Tyr Ile His 
            20                  25                  30          


Ile Arg Ile Gln Gln Arg Asn Gly Arg Lys Thr Leu Thr Thr Val Gln 
        35                  40                  45              


Gly Ile Ala Asp Asp Tyr Asp Lys Lys Lys Leu Val Lys Ala Phe Lys 
    50                  55                  60                  


Lys Lys Phe Ala Cys Asn Gly Thr Val Ile Glu His Pro Glu Tyr Gly 
65                  70                  75                  80  


Glu Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Ile Cys Gln Phe 
                85                  90                  95      


Leu Val Glu Ile Gly Leu Ala Lys Asp Asp Gln Leu Lys Val His Gly 
            100                 105                 110         


Phe 
    


<210> 8242
<211> 308
<212> PRT
<213> Homo sapiens

<400> 8242
Met Ala Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr 
1               5                   10                  15      


Ser Ile Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu 
            20                  25                  30          


Gly Asp Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr 
        35                  40                  45              


Lys Ala Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg 
    50                  55                  60                  


Lys Phe Pro Lys Leu Thr Ile Ile Gly Glu Glu Asp Leu Pro Ser Glu 
65                  70                  75                  80  


Glu Val Asp Gln Glu Leu Ile Glu Asp Ser Gln Trp Glu Glu Ile Leu 
                85                  90                  95      


Lys Gln Pro Cys Pro Ser Gln Tyr Ser Ala Ile Lys Glu Glu Asp Leu 
            100                 105                 110         


Val Val Trp Val Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly 
        115                 120                 125             


Leu Leu Asp Asn Val Thr Val Leu Ile Gly Ile Ala Tyr Glu Gly Lys 
    130                 135                 140                 


Ala Ile Ala Gly Val Ile Asn Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly 
145                 150                 155                 160 


Pro Asp Ala Val Leu Gly Arg Thr Ile Trp Gly Val Leu Gly Leu Gly 
                165                 170                 175     


Ala Phe Gly Phe Gln Leu Lys Glu Val Pro Ala Gly Lys His Ile Ile 
            180                 185                 190         


Thr Thr Thr Arg Ser His Ser Asn Lys Leu Val Thr Asp Cys Val Ala 
        195                 200                 205             


Ala Met Asn Pro Asp Ala Val Leu Arg Val Gly Gly Ala Gly Asn Lys 
    210                 215                 220                 


Ile Ile Gln Leu Ile Glu Gly Lys Ala Ser Ala Tyr Val Phe Ala Ser 
225                 230                 235                 240 


Pro Gly Cys Lys Lys Trp Asp Thr Cys Ala Pro Glu Val Ile Leu His 
                245                 250                 255     


Ala Val Gly Gly Lys Leu Thr Asp Ile His Gly Asn Val Leu Gln Tyr 
            260                 265                 270         


His Lys Asp Val Lys His Met Asn Ser Ala Gly Val Leu Ala Thr Leu 
        275                 280                 285             


Arg Asn Tyr Asp Tyr Tyr Ala Ser Arg Val Pro Glu Ser Ile Lys Asn 
    290                 295                 300                 


Ala Leu Val Pro 
305             


<210> 8243
<211> 602
<212> PRT
<213> Homo sapiens

<400> 8243
Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
1               5                   10                  15      


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
            20                  25                  30          


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
        35                  40                  45              


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
    50                  55                  60                  


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
65                  70                  75                  80  


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
                85                  90                  95      


Lys Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu 
            100                 105                 110         


Val Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg 
        115                 120                 125             


Leu Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile 
    130                 135                 140                 


Ser Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val 
145                 150                 155                 160 


Cys Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys 
                165                 170                 175     


Ala Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn 
            180                 185                 190         


Phe Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu 
        195                 200                 205             


Glu Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu 
    210                 215                 220                 


Glu Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg 
225                 230                 235                 240 


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr 
                245                 250                 255     


Cys Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu 
            260                 265                 270         


Pro Tyr Thr Glu Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
        275                 280                 285             


Gly Asn Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe 
    290                 295                 300                 


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val 
305                 310                 315                 320 


Gln Ala Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val 
                325                 330                 335     


Thr Ala Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro 
            340                 345                 350         


Ala Val Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys 
        355                 360                 365             


Leu Ile Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys 
    370                 375                 380                 


Leu Glu Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu 
385                 390                 395                 400 


Leu His Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp 
                405                 410                 415     


Lys Met Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys 
            420                 425                 430         


Arg Val Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser 
        435                 440                 445             


Asn Lys Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala 
    450                 455                 460                 


Pro Asn Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Ile Val 
465                 470                 475                 480 


Pro Gly Lys Ser Pro Thr Arg Lys Lys Ser Gly Pro Phe Gly Ser Arg 
                485                 490                 495     


Arg Ser Ser Ala Ile Gly Ile Glu Asn Ile Gln Glu Val Gln Glu Lys 
            500                 505                 510         


Arg Glu Ser Pro Pro Ala Gly Gln Lys Thr Pro Asp Ser Gly His Val 
        515                 520                 525             


Ser Gln Glu Pro Lys Ser Glu Asn Ser Ser Thr Gln Ser Ser Pro Glu 
    530                 535                 540                 


Met Pro Thr Thr Lys Asn Arg Ala Glu Thr Ala Ala Gln Arg Ala Glu 
545                 550                 555                 560 


Ala Leu Lys Asp Phe Ser Arg Ser Ser Ser Ser Ala Ser Ser Phe Ala 
                565                 570                 575     


Ser Val Val Glu Glu Thr Glu Gly Val Asp Gly Glu Asp Thr Gly Leu 
            580                 585                 590         


His Val Ala Gly Gly Gln Cys Gln His His 
        595                 600         


<210> 8244
<211> 58
<212> PRT
<213> Homo sapiens

<400> 8244
Met Gly Arg Val Trp Asp Leu Pro Gly Val Leu Lys Val Glu Gly Phe 
1               5                   10                  15      


Arg Ala Thr Met Ala Gln Arg Leu Val Arg Val Leu Gln Ile Cys Ala 
            20                  25                  30          


Gly His Val Pro Gly Val Ser Ala Leu Asn Leu Leu Ser Leu Leu Arg 
        35                  40                  45              


Ser Ser Glu Gly Pro Ser Leu Glu Asp Leu 
    50                  55              


<210> 8245
<211> 732
<212> PRT
<213> Homo sapiens

<400> 8245
Met Leu Pro Cys Ala Ala Gly Ala Arg Gly Arg Gly Ala Met Val Val 
1               5                   10                  15      


Leu Arg Ala Gly Lys Lys Thr Phe Leu Pro Pro Leu Cys Arg Ala Phe 
            20                  25                  30          


Ala Cys Arg Gly Cys Gln Leu Ala Pro Glu Arg Gly Ala Glu Arg Arg 
        35                  40                  45              


Asp Thr Ala Pro Ser Gly Val Ser Arg Phe Cys Pro Pro Arg Lys Ser 
    50                  55                  60                  


Cys His Asp Trp Ile Gly Pro Pro Asp Lys Tyr Ser Asn Leu Arg Pro 
65                  70                  75                  80  


Val His Phe Tyr Ile Pro Glu Asn Glu Ser Pro Leu Glu Gln Lys Leu 
                85                  90                  95      


Arg Lys Leu Arg Gln Glu Thr Gln Glu Trp Asn Gln Gln Phe Trp Ala 
            100                 105                 110         


Asn Gln Asn Leu Thr Phe Ser Lys Glu Lys Glu Glu Phe Ile His Ser 
        115                 120                 125             


Arg Leu Lys Thr Lys Gly Leu Gly Leu Arg Thr Glu Ser Gly Gln Lys 
    130                 135                 140                 


Ala Thr Leu Asn Ala Glu Glu Met Ala Asp Phe Tyr Lys Glu Phe Leu 
145                 150                 155                 160 


Ser Lys Asn Phe Gln Lys His Met Tyr Tyr Asn Arg Met Tyr Asp Asn 
                165                 170                 175     


Met Ser Thr Met Val Tyr Ile Lys Glu Asp Lys Leu Glu Lys Leu Thr 
            180                 185                 190         


Gln Asp Glu Ile Ile Ser Lys Thr Lys Gln Val Ile Gln Gly Leu Glu 
        195                 200                 205             


Ala Leu Lys Asn Glu His Asn Ser Ile Leu Gln Ser Leu Leu Glu Thr 
    210                 215                 220                 


Leu Lys Cys Leu Lys Lys Asp Asp Glu Ser Asn Leu Val Glu Glu Lys 
225                 230                 235                 240 


Ser Asn Met Ile Arg Lys Ser Leu Glu Met Leu Glu Leu Gly Leu Ser 
                245                 250                 255     


Glu Ala Gln Val Met Met Ala Leu Ser Asn His Leu Asn Ala Val Glu 
            260                 265                 270         


Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu Cys Gln Glu 
        275                 280                 285             


Asn Gln Trp Leu Arg Asp Glu Leu Ala Asn Thr Gln Gln Lys Leu Gln 
    290                 295                 300                 


Lys Ser Glu Gln Ser Val Ala Gln Leu Glu Glu Glu Lys Lys His Leu 
305                 310                 315                 320 


Glu Phe Met Asn Gln Leu Lys Lys Tyr Asp Asp Asp Ile Ser Pro Ser 
                325                 330                 335     


Glu Asp Lys Asp Thr Asp Ser Thr Lys Glu Pro Leu Asp Asp Leu Phe 
            340                 345                 350         


Pro Asn Asp Glu Asp Asp Pro Gly Gln Gly Ile Gln Gln Gln His Ser 
        355                 360                 365             


Ser Ala Ala Ala Ala Ala Gln Gln Gly Gly Tyr Glu Ile Pro Ala Arg 
    370                 375                 380                 


Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala Ser Gln Gly Arg 
385                 390                 395                 400 


Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu Glu Asp Leu Glu 
                405                 410                 415     


Lys Thr Ser Gly His Asp His Pro Asp Val Ala Thr Met Leu Asn Ile 
            420                 425                 430         


Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys Asp Ala Ala Asn 
        435                 440                 445             


Leu Leu Asn Asp Ala Leu Ala Ile Arg Glu Lys Thr Leu Gly Lys Asp 
    450                 455                 460                 


His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu Ala Val Leu Tyr Gly 
465                 470                 475                 480 


Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu Cys Lys Arg Ala Leu 
                485                 490                 495     


Glu Ile Arg Glu Lys Val Leu Gly Lys Asp His Pro Asp Val Ala Lys 
            500                 505                 510         


Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn Gln Gly Lys Tyr Glu 
        515                 520                 525             


Glu Val Glu Tyr Tyr Tyr Gln Arg Ala Leu Glu Ile Tyr Gln Thr Lys 
    530                 535                 540                 


Leu Gly Pro Asp Asp Pro Asn Val Ala Lys Thr Lys Asn Asn Leu Ala 
545                 550                 555                 560 


Ser Cys Tyr Leu Lys Gln Gly Lys Phe Lys Gln Ala Glu Thr Leu Tyr 
                565                 570                 575     


Lys Glu Ile Leu Thr Arg Ala His Glu Arg Glu Phe Gly Ser Val Asp 
            580                 585                 590         


Asp Glu Asn Lys Pro Ile Trp Met His Ala Glu Glu Arg Glu Glu Cys 
        595                 600                 605             


Lys Gly Lys Gln Lys Asp Gly Thr Ser Phe Gly Glu Tyr Gly Gly Trp 
    610                 615                 620                 


Tyr Lys Ala Cys Lys Val Asp Ser Pro Thr Val Thr Thr Thr Leu Lys 
625                 630                 635                 640 


Asn Leu Gly Ala Leu Tyr Arg Arg Gln Gly Lys Phe Glu Ala Ala Glu 
                645                 650                 655     


Thr Leu Glu Glu Ala Ala Met Arg Ser Arg Lys Gln Gly Leu Asp Asn 
            660                 665                 670         


Val His Lys Gln Arg Val Ala Glu Val Leu Asn Asp Pro Glu Asn Met 
        675                 680                 685             


Glu Lys Arg Arg Ser Arg Glu Ser Leu Asn Val Asp Val Val Lys Tyr 
    690                 695                 700                 


Glu Ser Gly Pro Asp Gly Gly Glu Glu Val Ser Met Ser Val Glu Trp 
705                 710                 715                 720 


Asn Gly Met Arg Lys Met Lys Leu Gly Leu Val Asn 
                725                 730         


<210> 8246
<211> 82
<212> PRT
<213> Homo sapiens

<400> 8246
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu 
        


<210> 8247
<211> 73
<212> PRT
<213> Homo sapiens

<400> 8247
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu 
65                  70              


<210> 8248
<211> 396
<212> PRT
<213> Homo sapiens

<400> 8248
Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Ser 
1               5                   10                  15      


Leu Ala Ala Pro Gly Gly Gly Gly Ala Ala Ala Gln Gln Leu Val Cys 
            20                  25                  30          


Gly Gly Gln Phe Gly Gly Ala Gly Pro Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Ser Gln Gln Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His 
65                  70                  75                  80  


Pro Asn Ile Tyr Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu 
                85                  90                  95      


Ala Leu Gln Asn Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser 
            100                 105                 110         


Phe Val Asn Ser Gln Glu Trp Thr Leu Ser Arg Ser Val Pro Glu Leu 
        115                 120                 125             


Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val 
    130                 135                 140                 


His Arg Tyr Leu Thr Gly Thr Tyr Val Gln Glu Glu Ser Pro Glu Gly 
145                 150                 155                 160 


Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu 
                165                 170                 175     


Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp 
            180                 185                 190         


Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe 
        195                 200                 205             


Gln Thr Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala 
    210                 215                 220                 


Ser Glu Val Pro Met Val Leu Val Gly Thr Gln Asp Ala Ile Ser Ala 
225                 230                 235                 240 


Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Thr 
                245                 250                 255     


Asp Leu Lys Arg Cys Thr Tyr Tyr Glu Thr Cys Ala Thr Tyr Gly Leu 
            260                 265                 270         


Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu 
        275                 280                 285             


Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn 
    290                 295                 300                 


Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His 
305                 310                 315                 320 


Ile Asn Gln Ala Thr Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser 
                325                 330                 335     


Ser Ser Val Pro Ser Thr Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile 
            340                 345                 350         


Glu Thr Ile Ala Ala Ser Ser Thr Pro Thr Pro Ile Arg Lys Gln Ser 
        355                 360                 365             


Lys Arg Arg Ser Asn Ile Phe Thr Ile Cys Ala Thr Val Ser Asn Phe 
    370                 375                 380                 


Ser Ser Thr Lys Arg Pro Phe Gln Leu Leu Pro Asn 
385                 390                 395     


<210> 8249
<211> 369
<212> PRT
<213> Homo sapiens

<400> 8249
Met Asp Ser Cys Leu Met Val Trp His Met Lys Pro Gln Ser Arg Ala 
1               5                   10                  15      


Tyr Arg Phe Thr Gly His Lys Asp Ala Val Thr Cys Val Asn Phe Ser 
            20                  25                  30          


Pro Ser Gly His Leu Leu Ala Ser Gly Ser Arg Asp Lys Thr Val Arg 
        35                  40                  45              


Ile Trp Val Pro Asn Val Lys Gly Glu Ser Thr Val Phe Arg Ala His 
    50                  55                  60                  


Thr Ala Thr Val Arg Ser Val His Phe Cys Ser Asp Gly Gln Ser Phe 
65                  70                  75                  80  


Val Thr Ala Ser Asp Asp Lys Thr Val Lys Val Trp Ala Thr His Arg 
                85                  90                  95      


Gln Lys Phe Leu Phe Ser Leu Ser Gln His Ile Asn Trp Val Arg Cys 
            100                 105                 110         


Ala Lys Phe Ser Pro Asp Gly Arg Leu Ile Val Ser Ala Ser Asp Asp 
        115                 120                 125             


Lys Thr Val Lys Leu Trp Asp Lys Ser Ser Arg Glu Cys Val His Ser 
    130                 135                 140                 


Tyr Cys Glu His Gly Gly Phe Val Thr Tyr Val Asp Phe His Pro Ser 
145                 150                 155                 160 


Gly Thr Cys Ile Ala Ala Ala Gly Met Asp Asn Thr Val Lys Val Trp 
                165                 170                 175     


Asp Val Arg Thr His Arg Leu Leu Gln His Tyr Gln Leu His Ser Ala 
            180                 185                 190         


Ala Val Asn Gly Leu Ser Phe His Pro Ser Gly Asn Tyr Leu Ile Thr 
        195                 200                 205             


Ala Ser Ser Asp Ser Thr Leu Lys Ile Leu Asp Leu Met Glu Gly Arg 
    210                 215                 220                 


Leu Leu Tyr Thr Leu His Gly His Gln Gly Pro Ala Thr Thr Val Ala 
225                 230                 235                 240 


Phe Ser Arg Thr Gly Glu Tyr Phe Ala Ser Gly Gly Ser Asp Glu Gln 
                245                 250                 255     


Val Met Val Trp Lys Ser Asn Phe Asp Ile Val Asp His Gly Glu Val 
            260                 265                 270         


Thr Lys Val Pro Arg Pro Pro Ala Thr Leu Ala Ser Ser Met Gly Asn 
        275                 280                 285             


Leu Pro Glu Val Asp Phe Pro Val Pro Pro Gly Arg Gly Arg Ser Val 
    290                 295                 300                 


Glu Ser Val Gln Ser Gln Pro Gln Glu Pro Val Ser Val Pro Gln Thr 
305                 310                 315                 320 


Leu Thr Ser Thr Leu Glu His Ile Val Gly Gln Leu Asp Val Leu Thr 
                325                 330                 335     


Gln Thr Val Ser Ile Leu Glu Gln Arg Leu Thr Leu Thr Glu Asp Lys 
            340                 345                 350         


Leu Lys Gln Cys Leu Glu Asn Gln Gln Leu Ile Met Gln Arg Ala Thr 
        355                 360                 365             


Pro 
    


<210> 8250
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8250
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Phe Leu Arg Thr Ile Pro Asp Pro Gly 
                85                  90                  95      


Asp Val Pro Asp Ser Phe Phe 
            100             


<210> 8251
<211> 89
<212> PRT
<213> Homo sapiens

<400> 8251
Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210> 8252
<211> 379
<212> PRT
<213> Homo sapiens

<400> 8252
Met Trp His Leu Asp Phe Gly Leu His Thr Gly Lys Thr Phe Gln Pro 
1               5                   10                  15      


Leu Pro Phe Ile Ile Val Val Tyr Pro Gly Ala Gly Arg Arg Trp Gly 
            20                  25                  30          


Leu Val Leu Ser Leu Ala Ser His Arg Arg Arg Thr Glu Ala Gly Gly 
        35                  40                  45              


Gly Thr Gly Pro Thr Ser Asp Thr Gly Trp Gly Cys Met Leu Arg Cys 
    50                  55                  60                  


Gly Gln Met Ile Phe Ala Gln Ala Leu Val Cys Arg His Leu Gly Arg 
65                  70                  75                  80  


Asp Trp Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp Ser Tyr Phe Ser 
                85                  90                  95      


Val Leu Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr Tyr Ser Ile His 
            100                 105                 110         


Gln Ile Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Gln Trp 
        115                 120                 125             


Tyr Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Val Phe 
    130                 135                 140                 


Asp Thr Trp Ser Ser Leu Ala Val His Ile Ala Met Asp Asn Thr Val 
145                 150                 155                 160 


Val Met Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser Val Pro Cys Ala 
                165                 170                 175     


Gly Ala Thr Ala Phe Pro Ala Asp Ser Asp Arg His Cys Asn Gly Phe 
            180                 185                 190         


Pro Ala Gly Ala Glu Val Thr Asn Arg Pro Ser Pro Trp Arg Pro Leu 
        195                 200                 205             


Val Leu Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp Ile Asn Glu Ala 
    210                 215                 220                 


Tyr Val Glu Thr Leu Lys His Cys Phe Met Met Pro Gln Ser Leu Gly 
225                 230                 235                 240 


Val Ile Gly Gly Lys Pro Asn Ser Ala His Tyr Phe Ile Gly Tyr Val 
                245                 250                 255     


Gly Glu Glu Leu Ile Tyr Leu Asp Pro His Thr Thr Gln Pro Ala Val 
            260                 265                 270         


Glu Pro Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser Phe His Cys Gln 
        275                 280                 285             


His Pro Pro Cys Arg Met Ser Ile Ala Glu Leu Asp Pro Ser Ile Ala 
    290                 295                 300                 


Val Gly Phe Phe Cys Lys Thr Glu Asp Asp Phe Asn Asp Trp Cys Gln 
305                 310                 315                 320 


Gln Val Lys Lys Leu Ser Leu Leu Gly Gly Ala Leu Pro Met Phe Glu 
                325                 330                 335     


Leu Val Glu Leu Gln Pro Ser His Leu Ala Cys Pro Asp Val Leu Asn 
            340                 345                 350         


Leu Ser Leu Asp Ser Ser Asp Val Glu Arg Leu Glu Arg Phe Phe Asp 
        355                 360                 365             


Ser Glu Asp Glu Asp Phe Glu Ile Leu Ser Leu 
    370                 375                 


<210> 8253
<211> 560
<212> PRT
<213> Homo sapiens

<400> 8253
Met Ser Glu His Ser Arg Asn Ser Asp Gln Glu Glu Leu Leu Asp Glu 
1               5                   10                  15      


Glu Ile Asn Glu Asp Glu Ile Leu Ala Asn Leu Ser Ala Glu Glu Leu 
            20                  25                  30          


Lys Glu Leu Gln Ser Glu Met Glu Val Met Ala Pro Asp Pro Ser Leu 
        35                  40                  45              


Pro Val Gly Met Ile Gln Lys Asp Gln Thr Asp Lys Pro Pro Thr Gly 
    50                  55                  60                  


Asn Phe Asn His Lys Ser Leu Val Asp Tyr Met Tyr Trp Glu Lys Ala 
65                  70                  75                  80  


Ser Arg Arg Met Leu Glu Glu Glu Arg Val Pro Val Thr Phe Val Lys 
                85                  90                  95      


Ser Glu Glu Lys Thr Gln Glu Glu His Glu Glu Ile Glu Lys Arg Asn 
            100                 105                 110         


Lys Asn Met Ala Gln Tyr Leu Lys Glu Lys Leu Asn Asn Glu Ile Val 
        115                 120                 125             


Ala Asn Lys Arg Glu Ser Lys Gly Ser Ser Asn Ile Gln Glu Thr Asp 
    130                 135                 140                 


Glu Glu Asp Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp Glu Gly Glu 
145                 150                 155                 160 


Asp Asp Gly Glu Glu Ser Glu Glu Thr Asn Arg Glu Glu Glu Gly Lys 
                165                 170                 175     


Ala Lys Glu Gln Ile Arg Asn Cys Glu Asn Asn Cys Gln Gln Val Thr 
            180                 185                 190         


Asp Lys Ala Phe Lys Glu Gln Arg Asp Arg Pro Glu Ala Gln Glu Gln 
        195                 200                 205             


Ser Glu Lys Lys Ile Ser Lys Leu Asp Pro Lys Lys Leu Ala Leu Asp 
    210                 215                 220                 


Thr Ser Phe Leu Lys Val Ser Thr Arg Pro Ser Gly Asn Gln Thr Asp 
225                 230                 235                 240 


Leu Asp Gly Ser Leu Arg Arg Val Arg Lys Asn Asp Pro Asp Met Lys 
                245                 250                 255     


Glu Leu Asn Leu Asn Asn Ile Glu Asn Ile Pro Lys Glu Met Leu Leu 
            260                 265                 270         


Asp Phe Val Asn Ala Met Lys Lys Asn Lys His Ile Lys Thr Phe Ser 
        275                 280                 285             


Leu Ala Asn Val Gly Ala Asp Glu Asn Val Ala Phe Ala Leu Ala Asn 
    290                 295                 300                 


Met Leu Arg Glu Asn Arg Ser Ile Thr Thr Leu Asn Ile Glu Ser Asn 
305                 310                 315                 320 


Phe Ile Thr Gly Lys Gly Ile Val Ala Ile Met Arg Cys Leu Gln Phe 
                325                 330                 335     


Asn Glu Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Met Leu 
            340                 345                 350         


Gly His His Ala Glu Met Glu Ile Ala Arg Leu Leu Lys Ala Asn Asn 
        355                 360                 365             


Thr Leu Leu Lys Met Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met 
    370                 375                 380                 


Val Val Thr Asn Leu Leu Thr Arg Asn Gln Asp Lys Gln Arg Gln Lys 
385                 390                 395                 400 


Arg Gln Glu Glu Gln Lys Gln Gln Gln Leu Lys Glu Gln Lys Lys Leu 
                405                 410                 415     


Ile Ala Met Leu Glu Asn Gly Leu Gly Leu Pro Pro Gly Met Trp Glu 
            420                 425                 430         


Leu Leu Gly Gly Pro Lys Pro Asp Ser Arg Met Gln Glu Phe Phe Gln 
        435                 440                 445             


Pro Pro Pro Pro Arg Pro Pro Asn Pro Gln Asn Val Pro Phe Ser Gln 
    450                 455                 460                 


Arg Ser Glu Met Met Lys Lys Pro Ser Gln Ala Pro Lys Tyr Arg Thr 
465                 470                 475                 480 


Asp Pro Asp Ser Phe Arg Val Val Lys Leu Lys Arg Ile Gln Arg Lys 
                485                 490                 495     


Ser Arg Met Pro Glu Ala Arg Glu Pro Pro Glu Lys Thr Asn Leu Lys 
            500                 505                 510         


Asp Val Ile Lys Thr Leu Lys Pro Val Pro Arg Asn Arg Pro Pro Pro 
        515                 520                 525             


Leu Val Glu Ile Thr Pro Arg Asp Gln Leu Leu Asn Asp Ile Arg His 
    530                 535                 540                 


Ser Ser Val Ala Tyr Leu Lys Pro Val Gln Leu Pro Lys Glu Leu Ala 
545                 550                 555                 560 


<210> 8254
<211> 109
<212> PRT
<213> Homo sapiens

<400> 8254
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln 
            100                 105                 


<210> 8255
<211> 202
<212> PRT
<213> Homo sapiens

<400> 8255
Met Gly Ser Arg Lys Lys Glu Ile Ala Leu Gln Val Asn Ile Ser Thr 
1               5                   10                  15      


Gln Glu Leu Trp Glu Glu Met Leu Ser Ser Lys Gly Leu Thr Val Val 
            20                  25                  30          


Asp Val Tyr Gln Gly Trp Cys Gly Pro Cys Lys Pro Val Val Ser Leu 
        35                  40                  45              


Phe Gln Lys Met Arg Ile Glu Val Gly Leu Asp Leu Leu His Phe Ala 
    50                  55                  60                  


Leu Ala Glu Ala Asp Arg Leu Asp Val Leu Glu Lys Tyr Arg Gly Lys 
65                  70                  75                  80  


Cys Glu Pro Thr Phe Leu Phe Tyr Ala Gly Gly Glu Leu Val Ala Val 
                85                  90                  95      


Val Arg Gly Ala Asn Ala Pro Leu Leu Gln Lys Thr Ile Leu Asp Gln 
            100                 105                 110         


Leu Glu Ala Glu Lys Lys Val Leu Ala Glu Gly Arg Glu Arg Lys Val 
        115                 120                 125             


Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val Ser His Gly 
    130                 135                 140                 


Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu Arg Thr Cys 
145                 150                 155                 160 


Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly Lys Thr Asp 
                165                 170                 175     


Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile Leu Thr Asn 
            180                 185                 190         


Glu Glu Arg Thr Met Thr Glu Ala Glu Val 
        195                 200         


<210> 8256
<211> 64
<212> PRT
<213> Homo sapiens

<400> 8256
Met Ala Pro Gln Lys Asp Arg Lys Pro Lys Arg Ser Thr Trp Arg Phe 
1               5                   10                  15      


Asn Leu Asp Leu Thr His Pro Val Glu Asp Gly Ile Phe Asp Ser Gly 
            20                  25                  30          


Asn Phe Gly Thr Phe Pro Ser Glu Tyr Leu Gly Phe Ser Ser Leu Val 
        35                  40                  45              


Leu His Phe Phe Cys Phe Lys Ile Gly Ala Ile Ser Thr Gly Glu Gly 
    50                  55                  60                  


<210> 8257
<211> 123
<212> PRT
<213> Homo sapiens

<400> 8257
Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys 
1               5                   10                  15      


Lys Leu Asn Gly Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met 
            20                  25                  30          


Ile Thr Asp Ile His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr 
        35                  40                  45              


Val Lys Lys Glu His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr 
    50                  55                  60                  


Asp Gly Glu His Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu 
65                  70                  75                  80  


His Leu Asn Pro Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser 
                85                  90                  95      


Ser Gln Ser Ser Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser 
            100                 105                 110         


Gln Glu Ser Met Ser Pro Thr Val Phe Leu Pro 
        115                 120             


<210> 8258
<211> 66
<212> PRT
<213> Homo sapiens

<400> 8258
Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly 
65      


<210> 8259
<211> 537
<212> PRT
<213> Homo sapiens

<400> 8259
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met Glu Cys Phe Leu Gln Tyr Val Tyr Thr Gly Lys 
        115                 120                 125             


Val Lys Ile Thr Thr Glu Asn Val Gln Tyr Leu Phe Glu Thr Ser Ser 
    130                 135                 140                 


Leu Phe Gln Ile Ser Val Leu Arg Asp Ala Cys Ala Lys Phe Leu Glu 
145                 150                 155                 160 


Glu Gln Leu Asp Pro Cys Asn Cys Leu Gly Ile Gln Arg Phe Ala Asp 
                165                 170                 175     


Thr His Ser Leu Lys Thr Leu Phe Thr Lys Cys Lys Asn Phe Ala Leu 
            180                 185                 190         


Gln Thr Phe Glu Asp Val Ser Gln His Glu Glu Phe Leu Glu Leu Asp 
        195                 200                 205             


Lys Asp Glu Leu Ile Asp Tyr Ile Cys Ser Asp Glu Leu Val Ile Gly 
    210                 215                 220                 


Lys Glu Glu Met Val Phe Glu Ala Val Met Arg Trp Val Tyr Arg Ala 
225                 230                 235                 240 


Val Asp Leu Arg Arg Pro Leu Leu His Glu Leu Leu Thr His Val Arg 
                245                 250                 255     


Leu Pro Leu Leu His Pro Asn Tyr Phe Val Gln Thr Val Glu Val Asp 
            260                 265                 270         


Gln Leu Ile Gln Asn Ser Pro Glu Cys Tyr Gln Leu Leu His Glu Ala 
        275                 280                 285             


Arg Arg Tyr His Ile Leu Gly Asn Glu Met Met Ser Pro Arg Thr Arg 
    290                 295                 300                 


Pro Arg Arg Ser Thr Gly Tyr Ser Glu Val Ile Val Val Val Gly Gly 
305                 310                 315                 320 


Cys Glu Arg Val Gly Gly Phe Asn Leu Pro Tyr Thr Glu Cys Tyr Asp 
                325                 330                 335     


Pro Val Thr Gly Glu Trp Lys Ser Leu Ala Lys Leu Pro Glu Phe Thr 
            340                 345                 350         


Lys Ser Glu Tyr Ala Val Cys Ala Leu Arg Asn Asp Ile Leu Val Ser 
        355                 360                 365             


Gly Gly Arg Ile Asn Ser Arg Asp Val Trp Ile Tyr Asn Ser Gln Leu 
    370                 375                 380                 


Asn Ile Trp Ile Arg Val Ala Ser Leu Asn Lys Gly Arg Trp Arg His 
385                 390                 395                 400 


Lys Met Ala Val Leu Leu Gly Lys Val Tyr Val Val Gly Gly Tyr Asp 
                405                 410                 415     


Gly Gln Asn Arg Leu Ser Ser Val Glu Cys Tyr Asp Ser Phe Ser Asn 
            420                 425                 430         


Arg Trp Thr Glu Val Ala Pro Leu Lys Glu Ala Val Ser Ser Pro Ala 
        435                 440                 445             


Val Thr Ser Cys Val Gly Lys Leu Phe Val Ile Gly Gly Gly Pro Asp 
    450                 455                 460                 


Asp Asn Thr Cys Ser Asp Lys Val Gln Ser Tyr Asp Pro Glu Thr Asn 
465                 470                 475                 480 


Ser Trp Leu Leu Arg Ala Ala Ile Pro Ile Ala Lys Arg Cys Ile Thr 
                485                 490                 495     


Ala Val Ser Leu Asn Asn Leu Ile Tyr Val Ala Gly Gly Leu Thr Lys 
            500                 505                 510         


Ala Ile Tyr Cys Tyr Asp Pro Val Glu Asp Tyr Trp Met His Val Gln 
        515                 520                 525             


Asn Thr Phe Ser Arg Gln Val Ile Thr 
    530                 535         


<210> 8260
<211> 536
<212> PRT
<213> Homo sapiens

<400> 8260
Met Arg Leu Glu Glu Leu Lys Arg Leu Gln Asn Pro Leu Glu Gln Val 
1               5                   10                  15      


Asn Asp Gly Lys Tyr Ser Phe Glu Asn Ile Gln Arg Ala Trp Arg Glu 
            20                  25                  30          


Tyr Leu Gln Arg Gln Glu Pro Leu Gly Lys Arg Ser Pro Ser Pro Pro 
        35                  40                  45              


Ser Val Ser Ser Glu Lys Leu Ser Ser Ser Val Ser Met Asn Thr Phe 
    50                  55                  60                  


Ser Asp Ser Ser Thr Pro Asp Tyr Arg Glu Asp Gly Met Asp Leu Gly 
65                  70                  75                  80  


Ser Asp Ala Gly Ser Ser Ser Ser Ser Ser Arg Ala Ser Ser Gln Ser 
                85                  90                  95      


Asn Ser Thr Lys Val Thr Pro Cys Ser Glu Cys Lys Ser Ser Ser Ser 
            100                 105                 110         


Pro Gly Gly Ser Leu Asp Leu Val Ser Ala Leu Glu Asp Tyr Glu Glu 
        115                 120                 125             


Pro Phe Pro Val Tyr Gln Lys Lys Val Ile Asp Glu Trp Ala Pro Glu 
    130                 135                 140                 


Glu Asp Gly Glu Glu Glu Glu Glu Glu Asp Glu Arg Asp Gln Arg Gly 
145                 150                 155                 160 


Tyr Arg Asp Asp Arg Ser Pro Ala Arg Glu Pro Gly Asp Val Ser Ala 
                165                 170                 175     


Arg Thr Arg Ser Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Met 
            180                 185                 190         


Pro Pro Pro Val Pro Asn Gly Asn Leu His Gln His Asp Pro Gln Asp 
        195                 200                 205             


Leu Arg His Asn Gly Asn Val Val Val Ala Gly Arg Pro Ser Cys Ser 
    210                 215                 220                 


Arg Gly Pro Arg Arg Ala Ile Gln Lys Pro Gln Pro Ala Gly Gly Arg 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Ala Ala Gly Gly Leu Cys Leu Gln Pro Pro 
                245                 250                 255     


Asp Gly Gly Thr Cys Val Pro Glu Glu Pro Pro Val Pro Pro Met Asp 
            260                 265                 270         


Trp Glu Ala Leu Glu Lys His Leu Ala Gly Leu Gln Phe Arg Glu Gln 
        275                 280                 285             


Glu Val Arg Asn Gln Gly Gln Ala Arg Thr Asn Ser Thr Ser Ala Gln 
    290                 295                 300                 


Lys Asn Glu Arg Glu Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe 
305                 310                 315                 320 


Phe Asp Asp Gly Pro Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys 
                325                 330                 335     


Pro Ser Leu Ser Ser Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys 
            340                 345                 350         


Phe Val Asn Asp Ser Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser 
        355                 360                 365             


Lys Thr Glu Thr Ser Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln 
    370                 375                 380                 


Ser Ser Ser Tyr Ser Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser 
385                 390                 395                 400 


Leu Asp Asp Met Asp Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu 
                405                 410                 415     


Ala Lys Met Ala Leu Ala Met Ala Lys Pro Met Ala Lys Met Gln Val 
            420                 425                 430         


Glu Val Glu Lys Gln Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu 
        435                 440                 445             


Pro His Met Pro His Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys 
    450                 455                 460                 


Pro Thr Asp Leu Arg Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val 
465                 470                 475                 480 


Asn Asp Leu His Ser Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln 
                485                 490                 495     


Leu Leu Leu Ile Arg Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu 
            500                 505                 510         


Val Asp Ile Glu Asp Leu Thr Arg His Ala Glu Ser Gln Gln Lys His 
        515                 520                 525             


Met Ala Glu Lys Met Pro Ala Lys 
    530                 535     


<210> 8261
<211> 209
<212> PRT
<213> Homo sapiens

<400> 8261
Met Ser Glu Asn Ala Ala Pro Gly Leu Ile Ser Glu Leu Lys Leu Ala 
1               5                   10                  15      


Val Pro Trp Gly His Ile Ala Ala Lys Ala Trp Gly Ser Leu Gln Gly 
            20                  25                  30          


Pro Pro Val Leu Cys Leu His Gly Trp Leu Asp Asn Ala Ser Ser Phe 
        35                  40                  45              


Asp Arg Leu Ile Pro Leu Leu Pro Gln Asp Phe Tyr Tyr Val Ala Met 
    50                  55                  60                  


Asp Phe Gly Gly His Gly Leu Ser Ser His Tyr Ser Pro Gly Val Pro 
65                  70                  75                  80  


Tyr Tyr Leu Gln Thr Phe Val Ser Glu Ile Arg Arg Val Val Ala Ala 
                85                  90                  95      


Leu Lys Trp Asn Arg Phe Ser Ile Leu Gly His Ser Phe Gly Gly Val 
            100                 105                 110         


Val Gly Gly Met Phe Phe Cys Thr Phe Pro Glu Met Val Asp Lys Leu 
        115                 120                 125             


Ile Leu Leu Asp Thr Pro Leu Phe Leu Leu Glu Ser Asp Glu Met Glu 
    130                 135                 140                 


Asn Leu Leu Thr Tyr Lys Arg Arg Ala Ile Glu His Val Leu Gln Val 
145                 150                 155                 160 


Glu Ala Ser Gln Glu Pro Ser His Val Phe Ser Leu Lys Gln Leu Leu 
                165                 170                 175     


Gln Arg Leu Leu Lys Ser Asn Ser His Leu Ser Glu Glu Cys Gly Glu 
            180                 185                 190         


Leu Leu Leu Gln Arg Gly Thr Thr Lys Val Ala Thr Gly Arg Glu Gln 
        195                 200                 205             


His 
    


<210> 8262
<211> 66
<212> PRT
<213> Homo sapiens

<400> 8262
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala 
65      


<210> 8263
<211> 686
<212> PRT
<213> Homo sapiens

<400> 8263
Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp Arg Lys Gln Ser Lys 
1               5                   10                  15      


Ala Lys Ile Pro Ser Ala Arg Ser Leu Asp Glu Ile Ala Met Asp Leu 
            20                  25                  30          


Thr Glu Thr Gly Thr Gln Arg Ala Ser Lys Leu Val Thr Leu Glu Thr 
        35                  40                  45              


Lys Ser Gln Phe Ile Met Ala Ser Asn Gly Ser Leu Ile Ser Ser Gly 
    50                  55                  60                  


Ser Gln Asp Ser Glu Val Ser Glu Glu Gln Lys Arg Glu Lys Ile Leu 
65                  70                  75                  80  


Glu Leu Lys Lys Lys Glu Lys Leu Leu Gln Glu Lys Leu Leu Lys Lys 
                85                  90                  95      


Val Glu Glu Leu Lys Lys Ile Cys Leu Arg Glu Ala Glu Leu Thr Gly 
            100                 105                 110         


Lys Met Pro Lys Glu Tyr Pro Leu Asn Ile Gly Glu Lys Pro Pro Gln 
        115                 120                 125             


Val Arg Arg Arg Val Gly Thr Ala Phe Lys Leu Asp Asp Asn Leu Leu 
    130                 135                 140                 


Pro Ser Glu Glu Asp Pro Ala Leu Gln Glu Leu Glu Ser Asn Phe Leu 
145                 150                 155                 160 


Ile Gln Gln Lys Leu Val Glu Ala Ala Lys Lys Leu Ala Asn Glu Pro 
                165                 170                 175     


Asp Leu Cys Lys Thr Val Lys Lys Lys Arg Lys Gln Asp Tyr Thr Asp 
            180                 185                 190         


Ala Met Lys Lys Leu Gln Glu Ile Glu Asn Ala Ile Asn Glu Tyr Arg 
        195                 200                 205             


Ile Arg Cys Gly Lys Lys Pro Ser Gln Lys Ala Thr Val Leu Pro Glu 
    210                 215                 220                 


Asp Ile Ile Pro Ser Glu Ser Ser Ser Leu Ser Asp Thr Thr Thr Tyr 
225                 230                 235                 240 


Asp Asp Pro Ser Asp Ala Phe Thr Phe Pro Gly Gln Arg Ser Ser Ser 
                245                 250                 255     


Val Pro His Ser Pro Arg Ile Leu Pro Pro Lys Ser Leu Gly Ile Glu 
            260                 265                 270         


Arg Ile His Phe Arg Lys Ser Ser Ile Asn Glu Gln Phe Val Asp Thr 
        275                 280                 285             


Arg Gln Ser Arg Glu Met Leu Ser Thr His Ser Ser Pro Tyr Lys Thr 
    290                 295                 300                 


Leu Glu Arg Arg Pro Gln Gly Gly Arg Ser Met Pro Thr Thr Pro Val 
305                 310                 315                 320 


Leu Thr Arg Asn Ala Tyr Ser Ser Ser His Leu Glu Pro Glu Ser Ser 
                325                 330                 335     


Ser Gln His Cys Arg Gln Arg Ser Gly Ser Leu Glu Ser Gln Ser His 
            340                 345                 350         


Leu Leu Ser Glu Met Asp Ser Asp Lys Pro Phe Phe Ser Leu Ser Lys 
        355                 360                 365             


Ser Gln Arg Ser Ser Ser Thr Glu Ile Leu Asp Asp Gly Ser Ser Tyr 
    370                 375                 380                 


Thr Ser Gln Ser Ser Thr Glu Tyr Tyr Cys Val Thr Pro Val Thr Gly 
385                 390                 395                 400 


Pro Tyr Tyr Thr Thr Gln Thr Leu Asp Thr Arg Thr Arg Gly Arg Arg 
                405                 410                 415     


Arg Ser Lys Lys Gln Asn Val Ser Thr Ser Asn Ser Gly Ser Met Pro 
            420                 425                 430         


Asn Leu Ala Gln Lys Asp Ser Leu Arg Asn Gly Val Tyr Ser Lys Ser 
        435                 440                 445             


Gln Glu Pro Pro Ser Ser Ser Tyr Tyr Ile Ala Gly Tyr Thr Pro Tyr 
    450                 455                 460                 


Ala Glu Cys Asp Phe Tyr Tyr Ser Gly Gly Tyr Val Tyr Glu Asn Asp 
465                 470                 475                 480 


Thr Glu Gly Gln Tyr Ser Val Asn Pro Ser Tyr Arg Ser Ser Ala His 
                485                 490                 495     


Tyr Gly Tyr Glu Arg Gln Arg Asp Tyr Ser Arg Ser Phe His Glu Asp 
            500                 505                 510         


Glu Val Asp Arg Val Pro His Asn Pro Tyr Ala Thr Leu Arg Leu Pro 
        515                 520                 525             


Arg Lys Ala Ala Ala Lys Ser Glu His Ile Thr Lys Asn Ile His Lys 
    530                 535                 540                 


Ala Leu Val Ala Glu His Leu Arg Gly Trp Tyr Gln Arg Ala Ser Gly 
545                 550                 555                 560 


Gln Lys Asp Gln Gly His Ser Pro Gln Thr Ser Phe Asp Ser Asp Arg 
                565                 570                 575     


Gly Ser Gln Arg Cys Leu Gly Phe Ala Gly Leu Gln Val Pro Cys Ser 
            580                 585                 590         


Pro Ser Ser Arg Ala Ser Ser Tyr Ser Ser Val Ser Ser Thr Asn Ala 
        595                 600                 605             


Ser Gly Asn Trp Arg Thr Gln Leu Thr Ile Gly Leu Ser Asp Tyr Glu 
    610                 615                 620                 


Thr Pro Ala His Ser Ser Tyr Thr Ser Cys Tyr Gly Asn Val Tyr Asn 
625                 630                 635                 640 


Pro Leu Pro Ser Pro Ser Arg Gln Tyr Thr Glu Ile Ser Gln Leu Asp 
                645                 650                 655     


Gly Thr Asp Gly Asn Gln Leu Glu Asp Asn Leu Glu Ser Ser Glu Gln 
            660                 665                 670         


Arg Leu Phe Trp His Glu Asp Ser Lys Pro Gly Thr Leu Val 
        675                 680                 685     


<210> 8264
<211> 72
<212> PRT
<213> Homo sapiens

<400> 8264
Met Met Glu Glu Ile Ser Ile Met Val Ala Tyr Asp Ala His Val Phe 
1               5                   10                  15      


Ser Gln Leu His Asp Glu Asp Phe Leu Thr Ser Leu Val Ala Ile Ser 
            20                  25                  30          


Lys Pro Arg Ser Met Val Pro Thr Lys Lys Leu Lys Lys Tyr Glu Lys 
        35                  40                  45              


Glu Tyr Gln Thr Met Arg Glu Ser Gln Leu Gln Gln Glu Asp Pro Met 
    50                  55                  60                  


Asp Arg Tyr Lys Phe Val Tyr Leu 
65                  70          


<210> 8265
<211> 654
<212> PRT
<213> Homo sapiens

<400> 8265
Met Asp Ser Leu Pro Asp Glu Phe Phe Val Arg His Pro Ala Val Glu 
1               5                   10                  15      


Asp Gln Arg Lys Glu Glu Thr Glu Asn Lys Leu Glu Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Asn Lys Gln Glu Asn Asp Ile Pro Thr Asp Leu Val Pro Val 
        35                  40                  45              


Asn Leu Leu Leu Glu Val Lys Lys Leu Leu Asn Ala Ile Asn Thr Leu 
    50                  55                  60                  


Pro Lys Gly Val Val Pro His Ile Lys Lys Phe Leu Gln Glu Asp Phe 
65                  70                  75                  80  


Ser Phe Gln Thr Met Gln Arg Glu Val Ala Ala Asn Ser Gln Asn Gly 
                85                  90                  95      


Glu Glu Ile Val Pro Ala Leu Thr Leu Arg Phe Leu Ile Thr Gln Leu 
            100                 105                 110         


Glu Ala Ala Leu Arg Asn Ile Gln Ala Gly Asn Tyr Thr Ala His Gln 
        115                 120                 125             


Ile Asn Ile Gly Tyr Tyr Leu Thr Leu Leu Phe Leu Tyr Gly Val Ala 
    130                 135                 140                 


Leu Thr Glu Arg Gly Lys Lys Glu Asp Tyr Thr Glu Ala Glu Asn Lys 
145                 150                 155                 160 


Phe Leu Val Met Lys Met Met Ile Gln Glu Asn Glu Ile Cys Glu Asn 
                165                 170                 175     


Phe Met Ser Leu Val Tyr Phe Gly Arg Gly Leu Leu Arg Cys Ala Gln 
            180                 185                 190         


Lys Arg Tyr Asn Gly Gly Leu Leu Glu Phe His Lys Ser Leu Gln Glu 
        195                 200                 205             


Ile Gly Asp Lys Asn Asp His Trp Phe Asp Ile Asp Pro Thr Glu Asp 
    210                 215                 220                 


Glu Asp Leu Pro Thr Thr Phe Lys Asp Leu Leu Asn Asn Phe Ile Lys 
225                 230                 235                 240 


Thr Thr Glu Ser Asn Ile Met Lys Gln Thr Ile Cys Ser Tyr Leu Asp 
                245                 250                 255     


Cys Glu Arg Ser Cys Glu Ala Asp Ile Leu Lys Asn Thr Ser Tyr Lys 
            260                 265                 270         


Gly Phe Phe Gln Leu Met Cys Ser Lys Ser Cys Cys Val Tyr Phe His 
        275                 280                 285             


Lys Ile Cys Trp Lys Lys Phe Lys Asn Leu Lys Tyr Pro Gly Glu Asn 
    290                 295                 300                 


Asp Gln Ser Phe Ser Gly Lys Lys Cys Leu Lys Glu Gly Cys Thr Gly 
305                 310                 315                 320 


Asp Met Val Arg Met Leu Gln Cys Asp Val Pro Gly Ile Val Lys Ile 
                325                 330                 335     


Leu Phe Glu Val Val Arg Lys Asp Glu Tyr Ile Thr Ile Glu Asn Leu 
            340                 345                 350         


Gly Ala Ser Tyr Arg Lys Leu Ile Ser Leu Lys Ile Thr Asp Thr Asp 
        355                 360                 365             


Ile Arg Pro Lys Ile Ser Leu Lys Phe Asn Thr Lys Asp Glu Met Pro 
    370                 375                 380                 


Ile Phe Lys Leu Asp Tyr Asn Tyr Phe Tyr His Leu Leu His Ile Ile 
385                 390                 395                 400 


Ile Ile Ser Gly Thr Asp Ile Val Arg Gln Ile Phe Asp Glu Ala Met 
                405                 410                 415     


Pro Pro Pro Leu Leu Lys Lys Glu Leu Leu Ile His Lys Asn Val Leu 
            420                 425                 430         


Glu Ser Tyr Tyr Asn His Leu Trp Thr Asn His Pro Leu Gly Gly Ser 
        435                 440                 445             


Trp His Leu Leu Tyr Pro Pro Asn Lys Glu Leu Pro Gln Ser Lys Gln 
    450                 455                 460                 


Phe Asp Leu Cys Leu Leu Leu Ala Leu Ile Lys His Leu Asn Val Phe 
465                 470                 475                 480 


Pro Ala Pro Lys Lys Gly Trp Asn Met Glu Pro Pro Ser Ser Asp Ile 
                485                 490                 495     


Ser Lys Ser Ala Asp Ile Leu Arg Leu Cys Lys Tyr Arg Asp Ile Leu 
            500                 505                 510         


Leu Ser Glu Ile Leu Met Asn Gly Leu Thr Glu Ser Gln Phe Asn Ser 
        515                 520                 525             


Ile Trp Lys Lys Val Ser Asp Ile Leu Leu Arg Leu Gly Met Met Gln 
    530                 535                 540                 


Glu Asp Ile Asp Lys Val Lys Glu Asn Pro Ile Glu Asn Ile Ser Leu 
545                 550                 555                 560 


Asp Tyr His Gln Leu Ser Val Tyr Leu Gly Ile Pro Val Pro Glu Ile 
                565                 570                 575     


Ile Gln Arg Met Leu Ser Cys Tyr Gln Gln Gly Ile Ala Leu Gln Ser 
            580                 585                 590         


Ile Thr Gly Ser Gln Arg Ile Glu Ile Glu Glu Leu Gln Asn Glu Glu 
        595                 600                 605             


Glu Glu Leu Ser Pro Pro Leu Met Glu Tyr Asn Ile Asn Val Lys Ser 
    610                 615                 620                 


His Pro Glu Ile Gln Phe Ala Glu Ile Asn Lys Asp Gly Thr Ser Ile 
625                 630                 635                 640 


Pro Ser Glu Ser Ser Thr Glu Ser Leu Lys Asp Leu Gln Glu 
                645                 650                 


<210> 8266
<211> 189
<212> PRT
<213> Homo sapiens

<400> 8266
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu 
            180                 185                 


<210> 8267
<211> 282
<212> PRT
<213> Homo sapiens

<400> 8267
Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Val Ser Val Gly Leu Trp Glu Ser Ser Gly Arg Thr Leu Asp Asp Phe 
    130                 135                 140                 


Leu Thr Phe Pro Arg His Val Phe Arg Val Met Ile Leu Pro Pro Pro 
145                 150                 155                 160 


Gly Gly Ser Thr Val Leu Pro Val Thr Pro Leu Ser Pro His Arg Leu 
                165                 170                 175     


Pro Ala Val Phe Ser Ser Ser Gln Asn Glu Asp Ile Thr Glu Pro Gln 
            180                 185                 190         


Ser Ile Leu Ala Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala 
        195                 200                 205             


Gln Gly Leu Leu Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu 
    210                 215                 220                 


Lys Glu Thr Thr Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro 
225                 230                 235                 240 


Ile Thr Val Ala His Val Asp Gly Gln Thr His Met Leu Phe Gly Ser 
                245                 250                 255     


Asp Arg Met Glu Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly 
            260                 265                 270         


Pro Ile Pro Pro Ala Val Asn Ala Arg Leu 
        275                 280         


<210> 8268
<211> 406
<212> PRT
<213> Homo sapiens

<400> 8268
Met Asp Gln Leu Glu Asn Ala Lys Met Glu His Thr Asn Ala Ser Phe 
1               5                   10                  15      


Asp Thr Phe Phe Cys Glu Thr Arg Ala Gly Lys His Val Pro Arg Ala 
            20                  25                  30          


Leu Phe Val Asp Leu Glu Pro Thr Val Ile Asp Gly Ile Arg Thr Gly 
        35                  40                  45              


Gln His Arg Ser Leu Phe His Pro Glu Gln Leu Leu Ser Gly Lys Glu 
    50                  55                  60                  


Asp Ala Ala Asn Asn Tyr Ala Arg Gly Arg Tyr Ser Val Gly Ser Glu 
65                  70                  75                  80  


Val Ile Asp Leu Val Leu Glu Arg Thr Arg Lys Leu Ala Glu Gln Cys 
                85                  90                  95      


Gly Gly Leu Gln Gly Phe Leu Ile Phe Arg Ser Phe Gly Gly Gly Thr 
            100                 105                 110         


Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Thr Gly Glu Tyr 
        115                 120                 125             


Ser Arg Lys Thr Lys Leu Glu Phe Ser Val Tyr Pro Ala Pro Arg Ile 
    130                 135                 140                 


Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Val Leu Thr Thr His Ser 
145                 150                 155                 160 


Thr Thr Glu His Thr Asp Cys Thr Phe Met Val Asp Asn Glu Ala Val 
                165                 170                 175     


Tyr Asp Ile Cys His Arg Lys Leu Gly Val Glu Cys Pro Ser His Ala 
            180                 185                 190         


Ser Ile Asn Arg Leu Val Val Gln Val Val Ser Ser Ile Thr Ala Ser 
        195                 200                 205             


Leu Arg Phe Glu Gly Pro Leu Asn Val Asp Leu Ile Glu Phe Gln Thr 
    210                 215                 220                 


Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Met Thr Ala Phe Ala 
225                 230                 235                 240 


Pro Ile Val Ser Ala Asp Lys Ala Tyr His Glu Gln Phe Ser Val Ser 
                245                 250                 255     


Asp Ile Thr Thr Ala Cys Phe Glu Ser Ser Asn Gln Leu Val Lys Cys 
            260                 265                 270         


Asp Pro Arg Leu Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg Gly 
        275                 280                 285             


Asp Val Val Pro Lys Glu Val Asn Ala Ala Ile Ala Ala Thr Lys Ser 
    290                 295                 300                 


Arg His Ser Val Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys Val 
305                 310                 315                 320 


Gly Ile Asn Asn Arg Pro Pro Thr Val Met Pro Gly Gly Asp Leu Ala 
                325                 330                 335     


Lys Val His Arg Ser Ile Cys Met Leu Ser Asn Thr Thr Ala Ile Val 
            340                 345                 350         


Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala Lys 
        355                 360                 365             


Arg Ala Phe Leu His Trp Tyr Leu Arg Glu Gly Met Glu Glu Ala Glu 
    370                 375                 380                 


Phe Leu Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Arg Asp Tyr Glu 
385                 390                 395                 400 


Glu Val Ala Gln Ser Phe 
                405     


<210> 8269
<211> 619
<212> PRT
<213> Homo sapiens

<400> 8269
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu Ala Gln Val Met Leu Ala Leu Ala Ser His Leu Ser 
                85                  90                  95      


Thr Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu 
            100                 105                 110         


Cys Gln Glu Asn Gln Trp Leu Arg Asp Glu Leu Ala Gly Thr Gln Gln 
        115                 120                 125             


Arg Leu Gln Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu Glu Lys 
    130                 135                 140                 


Lys His Leu Glu Phe Leu Gly Gln Leu Arg Gln Tyr Asp Glu Asp Gly 
145                 150                 155                 160 


His Thr Ser Glu Glu Lys Glu Gly Asp Ala Thr Lys Asp Ser Leu Asp 
                165                 170                 175     


Asp Leu Phe Pro Asn Glu Glu Glu Glu Asp Pro Ser Asn Gly Leu Ser 
            180                 185                 190         


Arg Gly Gln Gly Ala Thr Ala Ala Gln Gln Gly Gly Tyr Glu Ile Pro 
        195                 200                 205             


Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala Ala Gln 
    210                 215                 220                 


Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu Glu Asp 
225                 230                 235                 240 


Leu Glu Arg Thr Ser Gly Arg Gly His Pro Asp Val Ala Thr Met Leu 
                245                 250                 255     


Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys Glu Ala 
            260                 265                 270         


Ala His Leu Leu Asn Asp Ala Leu Ser Ile Arg Glu Ser Thr Leu Gly 
        275                 280                 285             


Pro Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu Ala Val Leu 
    290                 295                 300                 


Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu Cys Gln Arg 
305                 310                 315                 320 


Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Thr Asn His Pro Asp Val 
                325                 330                 335     


Ala Lys Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn Gln Gly Lys 
            340                 345                 350         


Tyr Glu Ala Val Glu Arg Tyr Tyr Gln Arg Ala Leu Ala Ile Tyr Glu 
        355                 360                 365             


Gly Gln Leu Gly Pro Asp Asn Pro Asn Val Ala Arg Thr Lys Asn Asn 
    370                 375                 380                 


Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Tyr Ala Glu Ala Glu Thr 
385                 390                 395                 400 


Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Val Gln Glu Phe Gly Ser 
                405                 410                 415     


Val Asp Asp Asp His Lys Pro Ile Trp Met His Ala Glu Glu Arg Glu 
            420                 425                 430         


Glu Met Ser Lys Ser Arg His His Glu Gly Gly Thr Pro Tyr Ala Glu 
        435                 440                 445             


Tyr Gly Gly Trp Tyr Lys Ala Cys Lys Val Ser Ser Pro Thr Val Asn 
    450                 455                 460                 


Thr Thr Leu Arg Asn Leu Gly Ala Leu Tyr Arg Arg Gln Gly Lys Leu 
465                 470                 475                 480 


Glu Ala Ala Glu Thr Leu Glu Glu Cys Ala Leu Arg Ser Arg Arg Gln 
                485                 490                 495     


Gly Thr Asp Pro Ile Ser Gln Thr Lys Val Ala Glu Leu Leu Gly Glu 
            500                 505                 510         


Ser Asp Gly Arg Arg Thr Ser Gln Glu Gly Pro Gly Asp Ser Val Lys 
        515                 520                 525             


Phe Glu Gly Gly Glu Asp Ala Ser Val Ala Val Glu Trp Ser Gly Asp 
    530                 535                 540                 


Gly Ser Gly Thr Leu Gln Arg Ser Gly Ser Leu Gly Lys Ile Arg Asp 
545                 550                 555                 560 


Val Leu Arg Arg Ser Ser Glu Leu Leu Val Arg Lys Leu Gln Gly Thr 
                565                 570                 575     


Glu Pro Arg Pro Ser Ser Ser Asn Met Lys Arg Ala Ala Ser Leu Asn 
            580                 585                 590         


Tyr Leu Asn Gln Pro Ser Ala Ala Pro Leu Gln Val Ser Arg Gly Leu 
        595                 600                 605             


Ser Ala Ser Thr Met Asp Leu Ser Ser Ser Ser 
    610                 615                 


<210> 8270
<211> 97
<212> PRT
<213> Homo sapiens

<400> 8270
Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Ile Ala Glu Ser Leu Phe Ser Val 
    50                  55                  60                  


Trp Ser Cys Ser Arg Arg Arg Leu Thr Asn Pro Arg Thr Arg Arg Arg 
65                  70                  75                  80  


Ser Pro Ser Trp Ser Leu Ala Thr Ser Val Thr Tyr Arg Ser Ser Gly 
                85                  90                  95      


Val 
    


<210> 8271
<211> 128
<212> PRT
<213> Homo sapiens

<400> 8271
Met Thr Asp Leu Val Ala Val Trp Asp Val Ala Leu Ser Asp Gly Val 
1               5                   10                  15      


His Lys Ile Glu Phe Glu His Gly Thr Thr Ser Gly Lys Arg Val Val 
            20                  25                  30          


Tyr Val Asp Gly Lys Glu Glu Ile Arg Lys Glu Trp Met Phe Lys Leu 
        35                  40                  45              


Val Gly Lys Glu Thr Phe Tyr Val Gly Ala Ala Lys Thr Lys Ala Thr 
    50                  55                  60                  


Ile Asn Ile Asp Ala Ile Ser Gly Phe Ala Tyr Glu Tyr Thr Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Lys Ser Leu Lys Lys Tyr Met Glu Asp Arg Ser Lys Thr 
                85                  90                  95      


Thr Asn Thr Trp Val Leu His Met Asp Gly Glu Asn Phe Arg Ile Val 
            100                 105                 110         


Leu Glu Lys Asp Ala Met Asp Val Trp Cys Asn Gly Lys Lys Leu Glu 
        115                 120                 125             


<210> 8272
<211> 292
<212> PRT
<213> Homo sapiens

<400> 8272
Met Thr Val Ser Lys Phe Met Ala Ile Gln Lys Ala Leu Gln Pro Asp 
1               5                   10                  15      


Trp Phe Gln Cys Leu Ser Asp Gly Glu Val Ser Cys Lys Glu Ala Thr 
            20                  25                  30          


Ser Ile Lys Arg Val Arg Lys Ser Val Asp Arg Ser Leu Leu Phe Leu 
        35                  40                  45              


Asp Asn Cys Leu Arg Leu Gln Glu Glu Ser Glu Val Leu Gln Lys Ser 
    50                  55                  60                  


Val Ile Ile Gly Val Ile Glu Gly Gly Asp Val Met Glu Glu Arg Leu 
65                  70                  75                  80  


Arg Ser Ala Arg Glu Thr Ala Lys Arg Pro Val Gly Gly Phe Leu Leu 
                85                  90                  95      


Asp Gly Phe Gln Gly Asn Pro Thr Thr Leu Glu Ala Arg Leu Arg Leu 
            100                 105                 110         


Leu Ser Ser Val Thr Ala Glu Leu Pro Glu Asp Lys Pro Arg Leu Ile 
        115                 120                 125             


Ser Gly Val Ser Arg Pro Asp Glu Val Leu Glu Cys Ile Glu Arg Gly 
    130                 135                 140                 


Val Asp Leu Phe Glu Ser Phe Phe Pro Tyr Gln Val Thr Glu Arg Gly 
145                 150                 155                 160 


Cys Ala Leu Thr Phe Ser Phe Asp Tyr Gln Pro Asn Pro Glu Glu Thr 
                165                 170                 175     


Leu Leu Gln Gln Asn Gly Thr Gln Glu Glu Ile Lys Cys Met Asp Gln 
            180                 185                 190         


Ile Lys Lys Ile Glu Thr Thr Gly Cys Asn Gln Glu Ile Thr Ser Phe 
        195                 200                 205             


Glu Ile Asn Leu Lys Glu Lys Lys Tyr Gln Glu Asp Phe Asn Pro Leu 
    210                 215                 220                 


Val Arg Gly Cys Ser Cys Tyr Cys Cys Lys Asn His Thr Arg Ala Tyr 
225                 230                 235                 240 


Ile His His Leu Leu Val Thr Asn Glu Leu Leu Ala Gly Val Leu Leu 
                245                 250                 255     


Met Met His Asn Phe Glu His Tyr Phe Gly Phe Phe His Tyr Ile Arg 
            260                 265                 270         


Glu Ala Leu Lys Ser Asp Lys Leu Ala Gln Leu Lys Glu Leu Ile His 
        275                 280                 285             


Arg Gln Ala Ser 
    290         


<210> 8273
<211> 199
<212> PRT
<213> Homo sapiens

<400> 8273
Met Arg Phe Arg Phe Cys Gly Asp Leu Asp Cys Pro Asp Trp Val Leu 
1               5                   10                  15      


Ala Glu Ile Ser Thr Leu Ala Lys Met Ser Ser Val Lys Leu Arg Leu 
            20                  25                  30          


Leu Cys Ser Gln Val Leu Lys Glu Leu Leu Gly Gln Gly Ile Asp Tyr 
        35                  40                  45              


Glu Lys Ile Leu Lys Leu Thr Ala Asp Ala Lys Phe Glu Ser Gly Asp 
    50                  55                  60                  


Val Lys Ala Thr Val Ala Val Leu Ser Phe Ile Leu Ser Ser Ala Ala 
65                  70                  75                  80  


Lys His Ser Val Asp Gly Glu Ser Leu Ser Ser Glu Leu Gln Gln Leu 
                85                  90                  95      


Gly Leu Pro Lys Glu His Ala Ala Ser Leu Cys Arg Cys Tyr Glu Glu 
            100                 105                 110         


Lys Gln Ser Pro Leu Gln Lys His Leu Arg Val Cys Ser Leu Arg Met 
        115                 120                 125             


Asn Arg Leu Ala Gly Val Gly Trp Arg Val Asp Tyr Thr Leu Ser Ser 
    130                 135                 140                 


Ser Leu Leu Gln Ser Val Glu Glu Pro Met Val His Leu Arg Leu Glu 
145                 150                 155                 160 


Val Ala Ala Ala Pro Gly Thr Pro Ala Gln Pro Val Ala Met Ser Leu 
                165                 170                 175     


Ser Ala Asp Lys Phe Gln Val Leu Leu Ala Glu Leu Lys Gln Ala Gln 
            180                 185                 190         


Thr Leu Met Ser Ser Leu Gly 
        195                 


<210> 8274
<211> 117
<212> PRT
<213> Homo sapiens

<400> 8274
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser Glu Leu Leu 
            100                 105                 110         


Met Ile Ile Gln Met 
        115         


<210> 8275
<211> 295
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8275
Xaa Thr Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp 
1               5                   10                  15      


Gln Val Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu 
            20                  25                  30          


Gly His Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn 
        35                  40                  45              


Tyr Leu Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp 
    50                  55                  60                  


Asn Val Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu 
65                  70                  75                  80  


Asp Ser Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val 
                85                  90                  95      


Thr Gly Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn 
            100                 105                 110         


Leu Leu Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu 
        115                 120                 125             


Ser Asp Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg 
    130                 135                 140                 


Gly Tyr Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp 
145                 150                 155                 160 


His Pro Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu 
                165                 170                 175     


Leu Asn Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg 
            180                 185                 190         


Val Leu Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile 
        195                 200                 205             


His Ser Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser 
    210                 215                 220                 


Glu Asp His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile 
225                 230                 235                 240 


Ala Glu Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn 
                245                 250                 255     


Pro Gln Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val 
            260                 265                 270         


Arg Ile Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu 
        275                 280                 285             


Glu Cys Ser Ser Met Asp Ser 
    290                 295 


<210> 8276
<211> 350
<212> PRT
<213> Homo sapiens

<400> 8276
Met Ala Arg Trp Ile Pro Thr Lys Arg Gln Lys Tyr Gly Val Ala Ile 
1               5                   10                  15      


Tyr Asn Tyr Asn Ala Ser Gln Asp Val Glu Leu Ser Leu Gln Ile Gly 
            20                  25                  30          


Asp Thr Val His Ile Leu Glu Met Tyr Glu Gly Trp Tyr Arg Gly Tyr 
        35                  40                  45              


Thr Leu Gln Asn Lys Ser Lys Lys Gly Ile Phe Pro Glu Thr Tyr Ile 
    50                  55                  60                  


His Leu Lys Glu Ala Thr Val Glu Asp Leu Gly Gln His Glu Thr Val 
65                  70                  75                  80  


Ile Pro Gly Glu Leu Pro Leu Val Gln Glu Leu Thr Ser Thr Leu Arg 
                85                  90                  95      


Glu Trp Ala Val Ile Trp Arg Lys Leu Tyr Val Asn Asn Lys Leu Thr 
            100                 105                 110         


Leu Phe Arg Gln Leu Gln Gln Met Thr Tyr Ser Leu Ile Glu Trp Arg 
        115                 120                 125             


Ser Gln Ile Leu Ser Gly Thr Leu Pro Lys Asp Glu Leu Ala Glu Leu 
    130                 135                 140                 


Lys Lys Lys Val Thr Ala Lys Ile Asp His Gly Asn Arg Met Leu Gly 
145                 150                 155                 160 


Leu Asp Leu Val Val Arg Asp Asp Asn Gly Asn Ile Leu Asp Pro Asp 
                165                 170                 175     


Glu Thr Ser Thr Ile Ala Leu Phe Lys Ala His Glu Val Ala Ser Lys 
            180                 185                 190         


Arg Ile Glu Glu Lys Ile Gln Glu Glu Lys Ser Ile Leu Gln Asn Leu 
        195                 200                 205             


Asp Leu Arg Gly Gln Ser Ile Phe Ser Thr Ile His Thr Tyr Gly Leu 
    210                 215                 220                 


Tyr Val Asn Phe Lys Asn Phe Val Cys Asn Ile Gly Glu Asp Ala Glu 
225                 230                 235                 240 


Leu Phe Met Ala Leu Tyr Asp Pro Asp Gln Ser Thr Phe Ile Ser Glu 
                245                 250                 255     


Asn Tyr Leu Ile Arg Trp Gly Ser Asn Gly Met Pro Lys Glu Ile Glu 
            260                 265                 270         


Lys Leu Asn Asn Leu Gln Ala Val Phe Thr Asp Leu Ser Ser Met Asp 
        275                 280                 285             


Leu Ile Arg Pro Arg Val Ser Leu Val Cys Gln Ile Val Arg Val Gly 
    290                 295                 300                 


His Met Glu Leu Lys Glu Gly Lys Lys His Thr Cys Gly Leu Arg Arg 
305                 310                 315                 320 


Pro Phe Gly Val Ala Val Met Asp Ile Thr Asp Ile Ile His Gly Lys 
                325                 330                 335     


Val Asp Asp Glu Glu Lys Gln His Phe Ile Pro Phe Gln Gln 
            340                 345                 350 


<210> 8277
<211> 119
<212> PRT
<213> Homo sapiens

<400> 8277
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser Glu Leu Leu 
            100                 105                 110         


Met Ile Ile Gln Met Glu Thr 
        115                 


<210> 8278
<211> 92
<212> PRT
<213> Homo sapiens

<400> 8278
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg 
1               5                   10                  15      


Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Leu Val Ser Gln Gly 
            20                  25                  30          


Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser 
        35                  40                  45              


Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val 
    50                  55                  60                  


His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu 
65                  70                  75                  80  


Gly Leu Ser Glu Ala Gln Val Met Leu Ala Leu Ala 
                85                  90          


<210> 8279
<211> 134
<212> PRT
<213> Homo sapiens

<400> 8279
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met Glu Cys Phe Leu Gln Tyr Val Tyr Thr Gly Lys 
        115                 120                 125             


Val Lys Ile Thr Thr Glu 
    130                 


<210> 8280
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8280
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Phe Leu Arg Thr Ile Pro Asp Pro Gly 
                85                  90                  95      


Asp Val Pro Asp Ser Phe Phe 
            100             


<210> 8281
<211> 640
<212> PRT
<213> Homo sapiens

<400> 8281
Met Gly Arg Arg Ser Gly Leu Leu Gly Leu Arg Pro Gly Pro Glu Pro 
1               5                   10                  15      


Val Ala Leu Glu Arg Val Ile Asn Lys Val His Leu Lys Ala Asn His 
            20                  25                  30          


Val Val Lys Arg Asp Val Asp Glu His Leu Arg Ile Lys Thr Val Tyr 
        35                  40                  45              


Asp Lys Ser Val Glu Glu Leu Leu Pro Glu Lys Lys Asn Leu Val Lys 
    50                  55                  60                  


Asn Lys Leu Phe Pro Gln Ala Ile Ser Tyr Leu Glu Lys Thr Phe Gln 
65                  70                  75                  80  


Val Arg Arg Pro Ala Gly Thr Ile Leu Leu Ser Arg Gln Cys Ala Thr 
                85                  90                  95      


Asn Gln Tyr Leu Arg Lys Glu Asn Asp Pro His Arg Tyr Cys Thr Gly 
            100                 105                 110         


Glu Cys Ala Ala His Thr Lys Cys Gly Pro Val Ile Val Pro Glu Glu 
        115                 120                 125             


His Leu Gln Gln Cys Arg Val Tyr Arg Gly Gly Lys Trp Pro His Gly 
    130                 135                 140                 


Ala Val Gly Val Pro Asp Gln Glu Gly Ile Ser Asp Ala Asp Phe Val 
145                 150                 155                 160 


Leu Tyr Val Gly Ala Leu Ala Thr Glu Arg Cys Ser His Glu Asn Ile 
                165                 170                 175     


Ile Ser Tyr Ala Ala Tyr Cys Gln Gln Glu Ala Asn Met Asp Arg Pro 
            180                 185                 190         


Ile Ala Gly Tyr Ala Asn Leu Cys Pro Asn Met Ile Ser Thr Gln Pro 
        195                 200                 205             


Gln Glu Phe Val Gly Met Leu Ser Thr Val Lys His Glu Val Ile His 
    210                 215                 220                 


Ala Leu Gly Phe Ser Ala Gly Leu Phe Ala Phe Tyr His Asp Lys Asp 
225                 230                 235                 240 


Gly Asn Pro Leu Thr Ser Arg Phe Ala Asp Gly Leu Pro Pro Phe Asn 
                245                 250                 255     


Tyr Ser Leu Gly Leu Tyr Gln Trp Ser Asp Lys Val Val Arg Lys Val 
            260                 265                 270         


Glu Arg Leu Trp Asp Val Arg Asp Asn Lys Ile Val Arg His Thr Val 
        275                 280                 285             


Tyr Leu Leu Val Thr Pro Arg Val Val Glu Glu Ala Arg Lys His Phe 
    290                 295                 300                 


Asp Cys Pro Val Leu Glu Gly Met Glu Leu Glu Asn Gln Gly Gly Val 
305                 310                 315                 320 


Gly Thr Glu Leu Asn His Trp Glu Lys Arg Leu Leu Glu Asn Glu Ala 
                325                 330                 335     


Met Thr Gly Ser His Thr Gln Asn Arg Val Leu Ser Arg Ile Thr Leu 
            340                 345                 350         


Ala Leu Met Glu Asp Thr Gly Trp Tyr Lys Ala Asn Tyr Ser Met Ala 
        355                 360                 365             


Glu Lys Leu Asp Trp Gly Arg Gly Met Gly Cys Asp Phe Val Arg Lys 
    370                 375                 380                 


Ser Cys Lys Phe Trp Ile Asp Gln Gln Arg Gln Lys Arg Gln Met Leu 
385                 390                 395                 400 


Ser Pro Tyr Cys Asp Thr Leu Arg Ser Asn Pro Leu Gln Leu Thr Cys 
                405                 410                 415     


Arg Gln Asp Gln Arg Ala Val Ala Val Cys Asn Leu Gln Lys Phe Pro 
            420                 425                 430         


Lys Pro Leu Pro Gln Glu Tyr Gln Tyr Phe Asp Glu Leu Ser Gly Ile 
        435                 440                 445             


Pro Ala Glu Asp Leu Pro Tyr Tyr Gly Gly Ser Val Glu Ile Ala Asp 
    450                 455                 460                 


Tyr Cys Pro Phe Ser Gln Glu Phe Ser Trp His Leu Ser Gly Glu Tyr 
465                 470                 475                 480 


Gln Arg Ser Ser Asp Cys Arg Ile Leu Glu Asn Gln Pro Glu Ile Phe 
                485                 490                 495     


Lys Asn Tyr Gly Ala Glu Lys Tyr Gly Pro His Ser Val Cys Leu Ile 
            500                 505                 510         


Gln Lys Ser Ala Phe Val Met Glu Lys Cys Glu Arg Lys Leu Ser Tyr 
        515                 520                 525             


Pro Asp Trp Gly Ser Gly Cys Tyr Gln Val Ser Cys Ser Pro Gln Gly 
    530                 535                 540                 


Leu Lys Val Trp Val Gln Asp Thr Ser Tyr Leu Cys Ser Arg Ala Gly 
545                 550                 555                 560 


Gln Val Leu Pro Val Ser Ile Gln Met Asn Gly Trp Ile His Asp Gly 
                565                 570                 575     


Asn Leu Leu Cys Pro Ser Cys Trp Asp Phe Cys Glu Leu Cys Pro Pro 
            580                 585                 590         


Glu Thr Asp Pro Pro Ala Thr Asn Leu Thr Arg Ala Leu Pro Leu Asp 
        595                 600                 605             


Leu Cys Ser Cys Ser Ser Ser Leu Val Val Thr Leu Trp Leu Leu Leu 
    610                 615                 620                 


Gly Asn Leu Phe Pro Leu Leu Ala Gly Phe Leu Leu Cys Ile Trp His 
625                 630                 635                 640 


<210> 8282
<211> 260
<212> PRT
<213> Homo sapiens

<400> 8282
Met Asn Leu Asp Ser Asp Gly Met Asp Asp Ile Ile Ser Gln Glu Ser 
1               5                   10                  15      


Ser Leu Asp Met Glu Gly Asn Tyr Lys Lys Ala Gln Lys Asn Glu Arg 
            20                  25                  30          


Glu Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe Phe Asp Asp Gly 
        35                  40                  45              


Pro Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys Pro Ser Leu Ser 
    50                  55                  60                  


Ser Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys Phe Val Asn Asp 
65                  70                  75                  80  


Ser Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser Lys Thr Glu Thr 
                85                  90                  95      


Ser Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln Ser Ser Ser Tyr 
            100                 105                 110         


Ser Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser Leu Asp Asp Met 
        115                 120                 125             


Asp Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu Ala Lys Met Ala 
    130                 135                 140                 


Leu Ala Met Ala Lys Pro Met Ala Lys Met Gln Val Glu Val Glu Lys 
145                 150                 155                 160 


Gln Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu Pro His Met Pro 
                165                 170                 175     


His Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys Pro Thr Asp Leu 
            180                 185                 190         


Arg Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val Asn Asp Leu His 
        195                 200                 205             


Ser Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln Leu Leu Leu Ile 
    210                 215                 220                 


Arg Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu Val Asp Ile Glu 
225                 230                 235                 240 


Asp Leu Thr Arg His Ala Glu Ser Gln Gln Lys His Met Ala Glu Lys 
                245                 250                 255     


Met Pro Ala Lys 
            260 


<210> 8283
<211> 210
<212> PRT
<213> Homo sapiens

<400> 8283
Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu 
            100                 105                 110         


Ser Gly Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu 
        115                 120                 125             


Pro Gly Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala 
    130                 135                 140                 


Ala Asn Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp 
145                 150                 155                 160 


Gln Asp Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro 
                165                 170                 175     


Asn His Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu 
            180                 185                 190         


Asp Lys Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly 
        195                 200                 205             


Leu Gln 
    210 


<210> 8284
<211> 126
<212> PRT
<213> Homo sapiens

<400> 8284
Met Asn Gln Arg Ser His Leu Gly Thr Thr Tyr Leu Asp Thr Ala Lys 
1               5                   10                  15      


Gly Ala Val Glu Thr Phe Met Lys Leu Arg Ala Arg Asp Pro Ala Ser 
            20                  25                  30          


Arg Gly Asp Arg Tyr Met Leu Val Thr Phe Glu Glu Pro Pro Tyr Ala 
        35                  40                  45              


Ile Lys Ala Gly Trp Lys Glu Asn His Ala Thr Phe Met Asn Glu Leu 
    50                  55                  60                  


Lys Asn Leu Gln Ala Glu Gly Leu Thr Thr Leu Gly Gln Ser Leu Arg 
65                  70                  75                  80  


Thr Ala Phe Asp Leu Leu Asn Leu Asn Arg Leu Val Thr Gly Ile Asp 
                85                  90                  95      


Asn Tyr Gly Gln Gly Arg Asn Pro Phe Phe Leu Glu Pro Ala Ile Ile 
            100                 105                 110         


Ile Thr Ile Thr Asp Gly Ser Lys Leu Thr Thr Thr Ser Gly 
        115                 120                 125     


<210> 8285
<211> 395
<212> PRT
<213> Homo sapiens

<400> 8285
Met Ala Asn Asp Pro Leu Glu Gly Phe His Glu Val Asn Leu Ala Ser 
1               5                   10                  15      


Pro Thr Ser Pro Asp Leu Leu Gly Val Tyr Glu Ser Gly Thr Gln Glu 
            20                  25                  30          


Gln Thr Thr Ser Pro Ser Val Ile Tyr Arg Pro His Pro Ser Ala Leu 
        35                  40                  45              


Ser Ser Val Pro Ile Gln Ala Asn Ala Leu Asp Val Ser Glu Leu Pro 
    50                  55                  60                  


Thr Gln Pro Val Tyr Ser Ser Pro Arg Arg Leu Asn Cys Ala Glu Ile 
65                  70                  75                  80  


Ser Ser Ile Ser Phe His Val Thr Asp Pro Ala Pro Cys Ser Thr Ser 
                85                  90                  95      


Gly Val Thr Ala Gly Leu Thr Lys Leu Thr Thr Arg Lys Asp Asn Tyr 
            100                 105                 110         


Asn Ala Glu Arg Glu Phe Leu Gln Gly Ala Thr Ile Thr Glu Ala Cys 
        115                 120                 125             


Asp Gly Ser Asp Asp Ile Phe Gly Leu Ser Thr Asp Ser Leu Ser Arg 
    130                 135                 140                 


Leu Arg Ser Pro Ser Val Leu Glu Val Arg Glu Lys Gly Tyr Glu Arg 
145                 150                 155                 160 


Leu Lys Glu Glu Leu Ala Lys Ala Gln Arg Glu Leu Lys Leu Lys Asp 
                165                 170                 175     


Glu Glu Cys Glu Arg Leu Ser Lys Val Arg Asp Gln Leu Gly Gln Glu 
            180                 185                 190         


Leu Glu Glu Leu Thr Ala Ser Leu Phe Glu Glu Ala His Lys Met Val 
        195                 200                 205             


Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu Lys Glu 
    210                 215                 220                 


Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala Leu Lys 
225                 230                 235                 240 


Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu Pro Leu 
                245                 250                 255     


Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn Lys Ser 
            260                 265                 270         


Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val Ile Gln 
        275                 280                 285             


Pro Ile Val Lys Asp Cys Lys Glu Ala Asp Leu Ser Leu Tyr Asn Glu 
    290                 295                 300                 


Phe Arg Leu Trp Lys Asp Glu Pro Thr Met Asp Arg Thr Cys Pro Phe 
305                 310                 315                 320 


Leu Asp Lys Ile Tyr Gln Glu Asp Ile Phe Pro Cys Leu Thr Phe Ser 
                325                 330                 335     


Lys Ser Glu Leu Ala Ser Ala Val Leu Glu Ala Val Glu Asn Asn Thr 
            340                 345                 350         


Leu Ser Ile Glu Pro Val Gly Leu Gln Pro Ile Arg Phe Val Lys Ala 
        355                 360                 365             


Ser Ala Val Glu Cys Gly Gly Pro Lys Ser Leu Leu Tyr Val Thr Phe 
    370                 375                 380                 


Leu His Thr Phe Asp Thr Phe Ser Arg Asp Ser 
385                 390                 395 


<210> 8286
<211> 261
<212> PRT
<213> Homo sapiens

<400> 8286
Met Gly Ser Arg Lys Lys Glu Ile Ala Leu Gln Val Asn Ile Ser Thr 
1               5                   10                  15      


Gln Glu Leu Trp Glu Glu Met Leu Ser Ser Lys Gly Leu Thr Val Val 
            20                  25                  30          


Asp Val Tyr Gln Gly Trp Cys Gly Pro Cys Lys Pro Val Val Ser Leu 
        35                  40                  45              


Phe Gln Lys Met Arg Ile Glu Val Gly Leu Asp Leu Leu His Phe Ala 
    50                  55                  60                  


Leu Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val Ser His 
65                  70                  75                  80  


Gly Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu Arg Thr 
                85                  90                  95      


Cys Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly Lys Thr 
            100                 105                 110         


Asp Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile Leu Thr 
        115                 120                 125             


Asn Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe Tyr Gln 
    130                 135                 140                 


His Lys Ala Gly Glu Glu Ala Phe Glu Lys Leu Val His His Met Cys 
145                 150                 155                 160 


Ser Gly Pro Ser His Leu Leu Ile Leu Thr Arg Thr Glu Gly Phe Glu 
                165                 170                 175     


Asp Val Val Thr Thr Trp Arg Thr Val Met Gly Pro Arg Asp Pro Asn 
            180                 185                 190         


Val Ala Arg Arg Glu Gln Pro Glu Ser Leu Arg Ala Gln Tyr Gly Thr 
        195                 200                 205             


Glu Met Pro Phe Asn Ala Val His Gly Ser Arg Asp Arg Glu Asp Ala 
    210                 215                 220                 


Asp Arg Glu Leu Ala Leu Leu Phe Pro Ser Leu Lys Phe Ser Asp Lys 
225                 230                 235                 240 


Asp Thr Glu Ala Pro Gln Gly Glu Ser Ser Thr Gln Pro Arg Leu Lys 
                245                 250                 255     


Ile Thr Asp Leu Asp 
            260     


<210> 8287
<211> 427
<212> PRT
<213> Homo sapiens

<400> 8287
Met Val Cys Trp Gln Asp Leu Glu Glu Ser Leu Arg Met Lys Leu Ser 
1               5                   10                  15      


Leu Thr Lys Val Val Asn Gly Cys Arg Leu Gly Lys Ile Lys Asn Leu 
            20                  25                  30          


Gly Lys Thr Gly Asp His Thr Met Asp Ile Pro Gly Cys Leu Leu Tyr 
        35                  40                  45              


Thr Lys Thr Gly Ser Ala Pro His Leu Thr His His Thr Leu His Asn 
    50                  55                  60                  


Ile His Gly Val Pro Ala Met Ala Gln Leu Thr Leu Ser Ser Leu Ala 
65                  70                  75                  80  


Glu His His Glu Val Leu Thr Glu Tyr Lys Glu Gly Val Gly Lys Phe 
                85                  90                  95      


Ile Gly Met Pro Glu Ser Leu Leu Tyr Cys Ser Leu His Asp Pro Val 
            100                 105                 110         


Ser Pro Cys Pro Ala Gly Tyr Val Thr Asn Lys Ser Val Ser Val Trp 
        115                 120                 125             


Ser Val Ala Gly Arg Val Glu Met Thr Val Ser Lys Phe Met Ala Ile 
    130                 135                 140                 


Gln Lys Ala Leu Gln Pro Asp Trp Phe Gln Cys Leu Ser Asp Gly Glu 
145                 150                 155                 160 


Val Ser Cys Lys Glu Ala Thr Ser Ile Lys Arg Val Arg Lys Ser Val 
                165                 170                 175     


Asp Arg Ser Leu Leu Phe Leu Asp Asn Cys Leu Arg Leu Gln Glu Glu 
            180                 185                 190         


Ser Glu Val Leu Gln Lys Ser Val Ile Ile Gly Val Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Met Glu Glu Arg Leu Arg Ser Ala Arg Glu Thr Ala Lys Arg 
    210                 215                 220                 


Pro Val Gly Gly Phe Leu Leu Asp Gly Phe Gln Gly Asn Pro Thr Thr 
225                 230                 235                 240 


Leu Glu Ala Arg Leu Arg Leu Leu Ser Ser Val Thr Ala Glu Leu Pro 
                245                 250                 255     


Glu Asp Lys Pro Arg Leu Ile Ser Gly Val Ser Arg Pro Asp Glu Val 
            260                 265                 270         


Leu Glu Cys Ile Glu Arg Gly Val Asp Leu Phe Glu Ser Phe Phe Pro 
        275                 280                 285             


Tyr Gln Val Thr Glu Arg Gly Cys Ala Leu Thr Phe Ser Phe Asp Tyr 
    290                 295                 300                 


Gln Pro Asn Pro Glu Glu Thr Leu Leu Gln Gln Asn Gly Thr Gln Glu 
305                 310                 315                 320 


Glu Ile Lys Cys Met Asp Gln Ile Lys Lys Ile Glu Thr Thr Gly Cys 
                325                 330                 335     


Asn Gln Glu Ile Thr Ser Phe Glu Ile Asn Leu Lys Glu Lys Lys Tyr 
            340                 345                 350         


Gln Glu Asp Phe Asn Pro Leu Val Arg Gly Cys Ser Cys Tyr Cys Cys 
        355                 360                 365             


Lys Asn His Thr Arg Ala Tyr Ile His His Leu Leu Val Thr Asn Glu 
    370                 375                 380                 


Leu Leu Ala Gly Val Leu Leu Met Met His Asn Phe Glu His Tyr Phe 
385                 390                 395                 400 


Gly Phe Phe His Tyr Ile Arg Glu Ala Leu Lys Ser Asp Lys Leu Ala 
                405                 410                 415     


Gln Leu Lys Glu Leu Ile His Arg Gln Ala Ser 
            420                 425         


<210> 8288
<211> 130
<212> PRT
<213> Homo sapiens

<400> 8288
Met Asn Gln Arg Ser His Leu Gly Thr Thr Tyr Leu Asp Thr Ala Lys 
1               5                   10                  15      


Gly Ala Val Glu Thr Phe Met Lys Leu Arg Ala Arg Asp Pro Ala Ser 
            20                  25                  30          


Arg Gly Asp Arg Tyr Met Leu Val Thr Phe Glu Glu Pro Pro Tyr Ala 
        35                  40                  45              


Ile Lys Ala Gly Trp Lys Glu Asn His Ala Thr Phe Met Asn Glu Leu 
    50                  55                  60                  


Lys Asn Leu Gln Ala Glu Gly Leu Thr Thr Leu Gly Gln Ser Leu Arg 
65                  70                  75                  80  


Thr Ala Phe Asp Leu Leu Asn Leu Asn Arg Leu Val Thr Gly Ile Asp 
                85                  90                  95      


Asn Tyr Gly Gln Gly Arg Asn Pro Phe Phe Leu Glu Pro Ala Ile Ile 
            100                 105                 110         


Ile Thr Ile Thr Asp Gly Ser Lys Leu Thr Thr Thr Ser Gly Val Gln 
        115                 120                 125             


Asp Glu 
    130 


<210> 8289
<211> 138
<212> PRT
<213> Homo sapiens

<400> 8289
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly 
    130                 135             


<210> 8290
<211> 563
<212> PRT
<213> Homo sapiens

<400> 8290
Met Arg Leu Glu Glu Leu Lys Arg Leu Gln Asn Pro Leu Glu Gln Val 
1               5                   10                  15      


Asn Asp Gly Lys Tyr Ser Phe Glu Asn His Gln Leu Ala Met Asp Ala 
            20                  25                  30          


Glu Asn Asn Ile Glu Lys Tyr Pro Leu Asn Leu Gln Pro Leu Glu Ser 
        35                  40                  45              


Lys Val Lys Ile Ile Gln Arg Ala Trp Arg Glu Tyr Leu Gln Arg Gln 
    50                  55                  60                  


Glu Pro Leu Gly Lys Arg Ser Pro Ser Pro Pro Ser Val Ser Ser Glu 
65                  70                  75                  80  


Lys Leu Ser Ser Ser Val Ser Met Asn Thr Phe Ser Asp Ser Ser Thr 
                85                  90                  95      


Pro Asp Tyr Arg Glu Asp Gly Met Asp Leu Gly Ser Asp Ala Gly Ser 
            100                 105                 110         


Ser Ser Ser Ser Ser Arg Ala Ser Ser Gln Ser Asn Ser Thr Lys Val 
        115                 120                 125             


Thr Pro Cys Ser Glu Cys Lys Ser Ser Ser Ser Pro Gly Gly Ser Leu 
    130                 135                 140                 


Asp Leu Val Ser Ala Leu Glu Asp Tyr Glu Glu Pro Phe Pro Val Tyr 
145                 150                 155                 160 


Gln Lys Lys Val Ile Asp Glu Trp Ala Pro Glu Glu Asp Gly Glu Glu 
                165                 170                 175     


Glu Glu Glu Glu Asp Glu Arg Asp Gln Arg Gly Tyr Arg Asp Asp Arg 
            180                 185                 190         


Ser Pro Ala Arg Glu Pro Gly Asp Val Ser Ala Arg Thr Arg Ser Gly 
        195                 200                 205             


Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Met Pro Pro Pro Val Pro 
    210                 215                 220                 


Asn Gly Asn Leu His Gln His Asp Pro Gln Asp Leu Arg His Asn Gly 
225                 230                 235                 240 


Asn Val Val Val Ala Gly Arg Pro Ser Cys Ser Arg Gly Pro Arg Arg 
                245                 250                 255     


Ala Ile Gln Lys Pro Gln Pro Ala Gly Gly Arg Arg Ser Gly Arg Gly 
            260                 265                 270         


Pro Ala Ala Gly Gly Leu Cys Leu Gln Pro Pro Asp Gly Gly Thr Cys 
        275                 280                 285             


Val Pro Glu Glu Pro Pro Val Pro Pro Met Asp Trp Glu Ala Leu Glu 
    290                 295                 300                 


Lys His Leu Ala Gly Leu Gln Phe Arg Glu Gln Glu Val Arg Asn Gln 
305                 310                 315                 320 


Gly Gln Ala Arg Thr Asn Ser Thr Ser Ala Gln Lys Asn Glu Arg Glu 
                325                 330                 335     


Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe Phe Asp Asp Gly Pro 
            340                 345                 350         


Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys Pro Ser Leu Ser Ser 
        355                 360                 365             


Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys Phe Val Asn Asp Ser 
    370                 375                 380                 


Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser Lys Thr Glu Thr Ser 
385                 390                 395                 400 


Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln Ser Ser Ser Tyr Ser 
                405                 410                 415     


Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser Leu Asp Asp Met Asp 
            420                 425                 430         


Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu Ala Lys Met Ala Leu 
        435                 440                 445             


Ala Met Ala Lys Pro Met Ala Lys Met Gln Val Glu Val Glu Lys Gln 
    450                 455                 460                 


Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu Pro His Met Pro His 
465                 470                 475                 480 


Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys Pro Thr Asp Leu Arg 
                485                 490                 495     


Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val Asn Asp Leu His Ser 
            500                 505                 510         


Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln Leu Leu Leu Ile Arg 
        515                 520                 525             


Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu Val Asp Ile Glu Asp 
    530                 535                 540                 


Leu Thr Arg His Ala Glu Ser Gln Gln Lys His Met Ala Glu Lys Met 
545                 550                 555                 560 


Pro Ala Lys 
            


<210> 8291
<211> 75
<212> PRT
<213> Homo sapiens

<400> 8291
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu 
65                  70                  75  


<210> 8292
<211> 903
<212> PRT
<213> Homo sapiens

<400> 8292
Met Pro Glu Gln Phe Ser Val Ala Glu Phe Leu Ala Val Thr Ala Glu 
1               5                   10                  15      


Asp Leu Ser Ser Pro Ala Gly Ala Ala Ala Phe Ala Ala Lys Met Pro 
            20                  25                  30          


Arg Tyr Arg Gly Ala Ala Leu Ala Arg Glu Glu Ile Leu Glu Gly Asp 
        35                  40                  45              


Gln Ala Ile Leu Gln Arg Ile Lys Lys Ala Val Arg Ala Ile His Ser 
    50                  55                  60                  


Ser Gly Leu Gly His Val Glu Asn Glu Glu Gln Tyr Arg Glu Ala Val 
65                  70                  75                  80  


Glu Ser Leu Gly Asn Ser His Leu Ser Gln Asn Ser His Glu Leu Ser 
                85                  90                  95      


Thr Gly Phe Leu Asn Leu Ala Val Phe Thr Arg Glu Val Ala Ala Leu 
            100                 105                 110         


Phe Lys Asn Leu Ile Gln Asn Leu Asn Asn Ile Val Ser Phe Pro Leu 
        115                 120                 125             


Asp Ser Leu Met Lys Gly Gln Leu Arg Asp Gly Arg Gln Asp Ser Lys 
    130                 135                 140                 


Lys Gln Leu Glu Lys Ala Trp Lys Asp Tyr Glu Ala Lys Met Ala Lys 
145                 150                 155                 160 


Leu Glu Lys Glu Arg Asp Arg Ala Arg Val Thr Gly Gly Ile Pro Gly 
                165                 170                 175     


Glu Val Ala Gln Asp Met Gln Arg Glu Arg Arg Ile Phe Gln Leu His 
            180                 185                 190         


Met Cys Glu Tyr Leu Leu Lys Ala Gly Glu Ser Gln Met Lys Gln Gly 
        195                 200                 205             


Pro Asp Phe Leu Gln Ser Leu Ile Lys Phe Phe His Ala Gln His Asn 
    210                 215                 220                 


Phe Phe Gln Asp Gly Trp Lys Ala Ala Gln Ser Leu Phe Pro Phe Ile 
225                 230                 235                 240 


Glu Lys Leu Ala Ala Ser Val His Ala Leu His Gln Ala Gln Glu Asp 
                245                 250                 255     


Glu Leu Gln Lys Leu Thr Gln Leu Arg Asp Ser Leu Arg Gly Thr Leu 
            260                 265                 270         


Gln Leu Glu Ser Arg Glu Glu His Leu Ser Arg Lys Asn Ser Gly Cys 
        275                 280                 285             


Gly Tyr Ser Ile His Gln His Gln Gly Asn Lys Gln Phe Gly Thr Glu 
    290                 295                 300                 


Lys Val Gly Phe Leu Tyr Lys Lys Ser Asp Gly Ile Arg Arg Val Trp 
305                 310                 315                 320 


Gln Lys Arg Lys Cys Gly Val Lys Tyr Gly Cys Leu Thr Ile Ser His 
                325                 330                 335     


Ser Thr Ile Asn Arg Pro Pro Val Lys Leu Thr Leu Leu Thr Cys Gln 
            340                 345                 350         


Val Arg Pro Asn Pro Glu Glu Lys Lys Cys Phe Asp Leu Val Thr His 
        355                 360                 365             


Asn Arg Thr Tyr His Phe Gln Ala Glu Asp Glu His Glu Cys Glu Ala 
    370                 375                 380                 


Trp Val Ser Val Leu Gln Asn Ser Lys Asp Glu Ala Leu Ser Ser Ala 
385                 390                 395                 400 


Phe Leu Gly Glu Pro Ser Ala Gly Pro Gly Ser Trp Gly Ser Ala Gly 
                405                 410                 415     


His Asp Gly Glu Pro His Asp Leu Thr Lys Leu Leu Ile Ala Glu Val 
            420                 425                 430         


Lys Ser Arg Pro Gly Asn Ser Gln Cys Cys Asp Cys Gly Ala Ala Asp 
        435                 440                 445             


Pro Thr Trp Leu Ser Thr Asn Leu Gly Val Leu Thr Cys Ile Gln Cys 
    450                 455                 460                 


Ser Gly Val His Arg Glu Leu Gly Val Arg Phe Ser Arg Met Gln Ser 
465                 470                 475                 480 


Leu Thr Leu Asp Leu Leu Gly Pro Ser Glu Leu Leu Leu Ala Leu Asn 
                485                 490                 495     


Met Gly Asn Thr Ser Phe Asn Glu Val Met Glu Ala Gln Leu Pro Ser 
            500                 505                 510         


His Gly Gly Pro Lys Pro Ser Ala Glu Ser Asp Met Gly Thr Arg Arg 
        515                 520                 525             


Asp Tyr Ile Met Ala Lys Tyr Val Glu His Arg Phe Ala Arg Arg Cys 
    530                 535                 540                 


Thr Pro Glu Pro Gln Arg Leu Trp Thr Ala Ile Cys Asn Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Val Leu Glu Ala Phe Ala Asn Gly Gln Asp Phe Gly Gln Pro 
                565                 570                 575     


Leu Pro Gly Pro Asp Ala Gln Ala Pro Glu Glu Leu Val Leu His Leu 
            580                 585                 590         


Ala Val Lys Val Ala Asn Gln Ala Ser Leu Pro Leu Val Asp Phe Ile 
        595                 600                 605             


Ile Gln Asn Gly Gly His Leu Asp Ala Lys Ala Ala Asp Gly Asn Thr 
    610                 615                 620                 


Ala Leu His Tyr Ala Ala Leu Tyr Asn Gln Pro Asp Cys Leu Lys Leu 
625                 630                 635                 640 


Leu Leu Lys Gly Arg Ala Leu Val Gly Thr Val Asn Glu Ala Gly Glu 
                645                 650                 655     


Thr Ala Leu Asp Ile Ala Arg Lys Lys His His Lys Glu Cys Glu Glu 
            660                 665                 670         


Leu Leu Glu Gln Ala Gln Ala Gly Thr Phe Ala Phe Pro Leu His Val 
        675                 680                 685             


Asp Tyr Ser Trp Val Ile Ser Thr Glu Pro Gly Ser Asp Ser Glu Glu 
    690                 695                 700                 


Asp Glu Glu Glu Lys Arg Cys Leu Leu Lys Leu Pro Ala Gln Ala His 
705                 710                 715                 720 


Trp Ala Ser Gly Arg Leu Asp Ile Ser Asn Lys Thr Tyr Glu Thr Val 
                725                 730                 735     


Ala Ser Leu Gly Ala Ala Thr Pro Gln Gly Glu Ser Glu Asp Cys Pro 
            740                 745                 750         


Pro Pro Leu Pro Val Lys Asn Ser Ser Arg Thr Leu Val Gln Gly Cys 
        755                 760                 765             


Ala Arg His Ala Ser Gly Asp Arg Ser Glu Val Ser Ser Leu Ser Ser 
    770                 775                 780                 


Glu Ala Pro Glu Thr Pro Glu Ser Leu Gly Ser Pro Ala Ser Ser Ser 
785                 790                 795                 800 


Ser Leu Met Ser Pro Leu Glu Pro Gly Asp Pro Ser Gln Ala Pro Pro 
                805                 810                 815     


Asn Ser Glu Glu Gly Leu Arg Glu Pro Pro Gly Thr Ser Arg Pro Ser 
            820                 825                 830         


Leu Thr Ser Gly Thr Thr Pro Ser Glu Met Tyr Leu Pro Val Arg Phe 
        835                 840                 845             


Ser Ser Glu Ser Thr Arg Ser Tyr Arg Arg Gly Ala Arg Ser Pro Glu 
    850                 855                 860                 


Asp Gly Pro Ser Ala Arg Gln Pro Leu Pro Arg Arg Asn Val Pro Val 
865                 870                 875                 880 


Gly Ile Thr Glu Gly Asp Gly Ser Arg Thr Gly Ser Leu Pro Ala Ser 
                885                 890                 895     


Ser Val Gln Leu Leu Gln Asp 
            900             


<210> 8293
<211> 173
<212> PRT
<213> Homo sapiens

<400> 8293
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp 
                165                 170             


<210> 8294
<211> 753
<212> PRT
<213> Homo sapiens

<400> 8294
Met Tyr Ser Pro Ile Ile Tyr Gln Ala Leu Cys Glu His Val Gln Thr 
1               5                   10                  15      


Gln Met Ser Leu Met Asn Asp Leu Thr Ser Lys Asn Ile Pro Asn Gly 
            20                  25                  30          


Ile Pro Ala Val Pro Cys His Ala Pro Ser His Ser Glu Ser Gln Ala 
        35                  40                  45              


Thr Pro His Ser Ser Tyr Gly Leu Cys Thr Ser Thr Pro Val Trp Ser 
    50                  55                  60                  


Leu Gln Arg Pro Pro Cys Pro Pro Lys Val His Ser Glu Val Gln Thr 
65                  70                  75                  80  


Asp Gly Asn Ser Gln Phe Ala Ser Gln Gly Lys Thr Val Ser Ala Thr 
                85                  90                  95      


Cys Thr Asp Val Leu Arg Asn Ser Phe Asn Thr Ser Pro Gly Val Pro 
            100                 105                 110         


Cys Ser Leu Pro Lys Thr Asp Ile Ser Ala Ile Pro Thr Leu Gln Gln 
        115                 120                 125             


Leu Gly Leu Val Asn Gly Ile Leu Pro Gln Gln Gly Ile His Lys Glu 
    130                 135                 140                 


Thr Asp Leu Leu Lys Cys Ile Gln Thr Tyr Leu Ser Leu Phe Arg Ser 
145                 150                 155                 160 


His Gly Lys Glu Thr His Leu Asp Ser Gln Thr His Arg Ser Pro Thr 
                165                 170                 175     


Gln Ser Gln Pro Ala Phe Leu Ala Thr Asn Glu Glu Lys Cys Ala Arg 
            180                 185                 190         


Glu Gln Ile Arg Glu Ala Thr Ser Glu Arg Lys Asp Leu Asn Ile His 
        195                 200                 205             


Val Arg Asp Thr Lys Thr Val Lys Asp Val Gln Lys Ala Lys Asn Val 
    210                 215                 220                 


Asn Lys Thr Ala Glu Lys Val Arg Ile Ile Lys Tyr Leu Leu Gly Glu 
225                 230                 235                 240 


Leu Lys Ala Leu Val Ala Glu Gln Glu Asp Ser Glu Ile Gln Arg Leu 
                245                 250                 255     


Ile Thr Glu Met Glu Ala Cys Ile Ser Val Leu Pro Thr Val Ser Gly 
            260                 265                 270         


Asn Thr Asp Ile Gln Val Glu Ile Ala Leu Ala Met Gln Pro Leu Arg 
        275                 280                 285             


Ser Glu Asn Ala Gln Leu Arg Arg Gln Leu Arg Ile Leu Asn Gln Gln 
    290                 295                 300                 


Leu Arg Glu Gln Gln Lys Thr Gln Lys Pro Ser Gly Ala Val Asp Cys 
305                 310                 315                 320 


Asn Leu Glu Leu Phe Ser Leu Gln Ser Leu Asn Met Ser Leu Gln Asn 
                325                 330                 335     


Gln Leu Glu Glu Ser Leu Lys Ser Gln Glu Leu Leu Gln Ser Lys Asn 
            340                 345                 350         


Glu Glu Leu Leu Lys Val Ile Glu Asn Gln Lys Asp Glu Asn Lys Lys 
        355                 360                 365             


Phe Ser Ser Ile Phe Lys Asp Lys Asp Gln Thr Ile Leu Glu Asn Lys 
    370                 375                 380                 


Gln Gln Tyr Asp Ile Glu Ile Thr Arg Ile Lys Ile Glu Leu Glu Glu 
385                 390                 395                 400 


Ala Leu Val Asn Val Lys Ser Ser Gln Phe Lys Leu Glu Thr Ala Glu 
                405                 410                 415     


Lys Glu Asn Gln Ile Leu Gly Ile Thr Leu Arg Gln Arg Asp Ala Glu 
            420                 425                 430         


Val Thr Arg Leu Arg Glu Leu Thr Arg Thr Leu Gln Thr Ser Met Ala 
        435                 440                 445             


Lys Leu Leu Ser Asp Leu Ser Val Asp Ser Ala Arg Cys Lys Pro Gly 
    450                 455                 460                 


Asn Asn Leu Thr Lys Ser Leu Leu Asn Ile His Asp Lys Gln Leu Gln 
465                 470                 475                 480 


His Asp Pro Ala Pro Ala His Thr Ser Ile Met Ser Tyr Leu Asn Lys 
                485                 490                 495     


Leu Glu Thr Asn Tyr Ser Phe Thr His Ser Glu Pro Leu Ser Thr Ile 
            500                 505                 510         


Lys Asn Glu Glu Thr Ile Glu Pro Asp Lys Thr Tyr Glu Asn Val Leu 
        515                 520                 525             


Ser Ser Arg Gly Pro Gln Asn Ser Asn Thr Arg Gly Met Glu Glu Ala 
    530                 535                 540                 


Ser Ala Pro Gly Ile Ile Ser Ala Leu Ser Lys Gln Asp Ser Asp Glu 
545                 550                 555                 560 


Gly Ser Glu Thr Met Ala Leu Ile Glu Asp Glu His Asn Leu Asp Asn 
                565                 570                 575     


Thr Ile Tyr Ile Pro Phe Ala Arg Ser Thr Pro Glu Lys Lys Ser Pro 
            580                 585                 590         


Leu Ser Lys Arg Leu Ser Pro Gln Pro Gln Ile Arg Ala Ala Thr Thr 
        595                 600                 605             


Gln Leu Val Ser Asn Ser Gly Leu Ala Val Ser Gly Lys Glu Asn Lys 
    610                 615                 620                 


Leu Cys Thr Pro Val Ile Cys Ser Ser Ser Thr Lys Glu Ala Glu Asp 
625                 630                 635                 640 


Ala Pro Glu Lys Leu Ser Arg Ala Ser Asp Met Lys Asp Thr Gln Leu 
                645                 650                 655     


Leu Lys Lys Ile Lys Glu Ala Ile Gly Lys Ile Pro Ala Ala Thr Lys 
            660                 665                 670         


Glu Pro Glu Glu Gln Thr Ala Cys His Gly Pro Ser Gly Cys Leu Ser 
        675                 680                 685             


Asn Ser Leu Gln Val Lys Gly Asn Thr Val Cys Asp Gly Ser Val Phe 
    690                 695                 700                 


Thr Ser Asp Leu Met Ser Asp Trp Ser Ile Ser Ser Phe Ser Thr Phe 
705                 710                 715                 720 


Thr Ser Arg Asp Glu Gln Asp Phe Arg Asn Gly Leu Ala Ala Leu Asp 
                725                 730                 735     


Ala Asn Ile Ala Arg Leu Gln Lys Ser Leu Arg Thr Gly Leu Leu Glu 
            740                 745                 750         


Lys 
    


<210> 8295
<211> 72
<212> PRT
<213> Homo sapiens

<400> 8295
Met Met Glu Glu Ile Ser Ile Met Val Ala Tyr Asp Ala His Val Phe 
1               5                   10                  15      


Ser Gln Leu His Asp Glu Asp Phe Leu Thr Ser Leu Val Ala Ile Ser 
            20                  25                  30          


Lys Pro Arg Ser Met Val Pro Thr Lys Lys Leu Lys Lys Tyr Glu Lys 
        35                  40                  45              


Glu Tyr Gln Thr Met Arg Glu Ser Gln Leu Gln Gln Glu Asp Pro Met 
    50                  55                  60                  


Asp Arg Tyr Lys Phe Val Tyr Leu 
65                  70          


<210> 8296
<211> 195
<212> PRT
<213> Homo sapiens

<400> 8296
Met Trp His Met Thr Arg Asn Trp Pro Leu Val Gly Lys Thr Ser Leu 
1               5                   10                  15      


Ile Thr Arg Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr 
            20                  25                  30          


Ile Gly Ile Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr 
        35                  40                  45              


Val Arg Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser 
    50                  55                  60                  


Leu Ile Pro Ser Tyr Ile Arg Asp Ser Thr Val Ala Val Val Val Tyr 
65                  70                  75                  80  


Asp Ile Thr Asn Leu Asn Ser Phe Gln Gln Thr Ser Lys Trp Ile Asp 
                85                  90                  95      


Asp Val Arg Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly 
            100                 105                 110         


Asn Lys Thr Asp Leu Ala Asp Lys Arg Gln Ile Thr Ile Glu Glu Gly 
        115                 120                 125             


Glu Gln Arg Ala Lys Glu Leu Ser Val Met Phe Ile Glu Thr Ser Ala 
    130                 135                 140                 


Lys Thr Gly Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ser Ala 
145                 150                 155                 160 


Leu Pro Gly Met Glu Asn Val Gln Glu Lys Ser Lys Glu Gly Met Ile 
                165                 170                 175     


Asp Ile Lys Leu Asp Lys Pro Gln Glu Pro Pro Ala Ser Glu Gly Gly 
            180                 185                 190         


Cys Ser Cys 
        195 


<210> 8297
<211> 348
<212> PRT
<213> Homo sapiens

<400> 8297
Met Ser Leu Pro Arg Phe Gln Arg Val Asn Phe Gly Pro Tyr Asp Asn 
1               5                   10                  15      


Tyr Ile Pro Val Ser Glu Leu Ser Lys Lys Ser Trp Asn Gln Gln His 
            20                  25                  30          


Phe Ala Leu Leu Phe Pro Lys Pro Gln Arg Pro Gly Thr Lys Arg Arg 
        35                  40                  45              


Ser Lys Pro Ser Gln Ile Arg Asp Asn Thr Val Ser Ile Ile Asp Glu 
    50                  55                  60                  


Glu Gln Leu Arg Gly Asp Arg Arg Gln Pro Leu Trp Met Tyr Arg Ser 
65                  70                  75                  80  


Leu Met Arg Ile Ser Glu Arg Pro Ser Val Tyr Leu Ala Ala Arg Arg 
                85                  90                  95      


Gln Pro Leu Lys Pro Thr Arg Thr Val Glu Val Asp Ser Lys Ala Ala 
            100                 105                 110         


Glu Ile Gly Lys Lys Gly Glu Asp Lys Thr Thr Gln Lys Asp Thr Thr 
        115                 120                 125             


Asp Ser Glu Ser Glu Leu Lys Gln Gly Lys Lys Asp Ser Lys Lys Gly 
    130                 135                 140                 


Lys Asp Ile Glu Lys Gly Lys Glu Glu Lys Leu Asp Ala Lys Lys Asp 
145                 150                 155                 160 


Ser Lys Lys Gly Lys Lys Asp Ala Glu Lys Gly Lys Asp Ser Ala Thr 
                165                 170                 175     


Glu Ser Glu Asp Glu Lys Gly Gly Ala Lys Lys Asp Asn Lys Lys Asp 
            180                 185                 190         


Lys Lys Asp Ser Asn Lys Gly Lys Asp Ser Ala Thr Glu Ser Glu Gly 
        195                 200                 205             


Glu Lys Gly Gly Thr Glu Lys Asp Ser Lys Lys Gly Lys Lys Asp Ser 
    210                 215                 220                 


Lys Lys Gly Lys Asp Ser Ala Ile Glu Leu Gln Ala Val Lys Ala Asp 
225                 230                 235                 240 


Glu Lys Lys Asp Glu Asp Gly Lys Lys Asp Ala Asn Lys Gly Asp Glu 
                245                 250                 255     


Ser Lys Asp Ala Lys Lys Asp Ala Lys Glu Ile Lys Lys Gly Lys Lys 
            260                 265                 270         


Asp Lys Lys Lys Pro Ser Ser Thr Asp Ser Asp Ser Lys Asp Asp Val 
        275                 280                 285             


Lys Lys Glu Ser Lys Lys Asp Ala Thr Lys Asp Ala Lys Lys Val Ala 
    290                 295                 300                 


Lys Lys Asp Thr Glu Lys Glu Ser Ala Asp Ser Lys Lys Asp Ala Lys 
305                 310                 315                 320 


Lys Asn Ala Lys Lys Asp Ala Lys Lys Asp Ala Lys Lys Asn Ala Lys 
                325                 330                 335     


Lys Asp Glu Lys Lys Asp Ala Lys Lys Lys Gly Lys 
            340                 345             


<210> 8298
<211> 953
<212> PRT
<213> Homo sapiens

<400> 8298
Met Lys Arg Gly Ile Arg Arg Asp Pro Phe Arg Lys Arg Lys Leu Gly 
1               5                   10                  15      


Gly Arg Ala Lys Lys Val Arg Glu Pro Thr Ala Val Asn Ser Phe Tyr 
            20                  25                  30          


Arg Glu Ala Ser Leu Pro Ser Val Trp Ala Ser Leu Arg Arg Arg Glu 
        35                  40                  45              


Met Val Arg Ser Gly Ala Arg Pro Gly Gln Val Leu Ser Ser Gly Arg 
    50                  55                  60                  


His Thr Gly Pro Ala Lys Leu Thr Asn Gly Lys Lys Ala Thr Tyr Leu 
65                  70                  75                  80  


Arg Lys Ile Pro Arg Phe Asn Ala Asp Ser Gly Tyr Ser Ile His Ser 
                85                  90                  95      


Asp Ser Glu Ser Gln Ala Glu Thr Val His Gly Leu Asp Gly Cys Ala 
            100                 105                 110         


Ser Leu Leu Arg Asp Ile Leu Arg Asn Glu Asp Ser Gly Ser Glu Thr 
        115                 120                 125             


Ala Tyr Leu Glu Asn Arg Ser Asn Ser Arg Pro Leu Glu Ser Lys Arg 
    130                 135                 140                 


Tyr Gly Ser Lys Lys Lys Arg His Glu Lys His Thr Ile Pro Leu Val 
145                 150                 155                 160 


Val Gln Lys Glu Thr Ser Ser Ser Asp Asn Lys Lys Gln Ile Pro Asn 
                165                 170                 175     


Glu Ala Ser Ala Arg Ser Glu Arg Asp Thr Ser Asp Leu Glu Gln Asn 
            180                 185                 190         


Trp Ser Leu Gln Asp His Tyr Arg Met Tyr Ser Pro Ile Ile Tyr Gln 
        195                 200                 205             


Ala Leu Cys Glu His Val Gln Thr Gln Met Ser Leu Met Asn Asp Leu 
    210                 215                 220                 


Thr Ser Lys Asn Ile Pro Asn Gly Ile Pro Ala Val Pro Cys His Ala 
225                 230                 235                 240 


Pro Ser His Ser Glu Ser Gln Ala Thr Pro His Ser Ser Tyr Gly Leu 
                245                 250                 255     


Cys Thr Ser Thr Pro Val Trp Ser Leu Gln Arg Pro Pro Cys Pro Pro 
            260                 265                 270         


Lys Val His Ser Glu Val Gln Thr Asp Gly Asn Ser Gln Phe Ala Ser 
        275                 280                 285             


Gln Gly Lys Thr Val Ser Ala Thr Cys Thr Asp Val Leu Arg Asn Ser 
    290                 295                 300                 


Phe Asn Thr Ser Pro Gly Val Pro Cys Ser Leu Pro Lys Thr Asp Ile 
305                 310                 315                 320 


Ser Ala Ile Pro Thr Leu Gln Gln Leu Gly Leu Val Asn Gly Ile Leu 
                325                 330                 335     


Pro Gln Gln Gly Ile His Lys Glu Thr Asp Leu Leu Lys Cys Ile Gln 
            340                 345                 350         


Thr Tyr Leu Ser Leu Phe Arg Ser His Gly Lys Glu Thr His Leu Asp 
        355                 360                 365             


Ser Gln Thr His Arg Ser Pro Thr Gln Ser Gln Pro Ala Phe Leu Ala 
    370                 375                 380                 


Thr Asn Glu Glu Lys Cys Ala Arg Glu Gln Ile Arg Glu Ala Thr Ser 
385                 390                 395                 400 


Glu Arg Lys Asp Leu Asn Ile His Val Arg Asp Thr Lys Thr Val Lys 
                405                 410                 415     


Asp Val Gln Lys Ala Lys Asn Val Asn Lys Thr Ala Glu Lys Val Arg 
            420                 425                 430         


Ile Ile Lys Tyr Leu Leu Gly Glu Leu Lys Ala Leu Val Ala Glu Gln 
        435                 440                 445             


Glu Asp Ser Glu Ile Gln Arg Leu Ile Thr Glu Met Glu Ala Cys Ile 
    450                 455                 460                 


Ser Val Leu Pro Thr Val Ser Gly Asn Thr Asp Ile Gln Val Glu Ile 
465                 470                 475                 480 


Ala Leu Ala Met Gln Pro Leu Arg Ser Glu Asn Ala Gln Leu Arg Arg 
                485                 490                 495     


Gln Leu Arg Ile Leu Asn Gln Gln Leu Arg Glu Gln Gln Lys Thr Gln 
            500                 505                 510         


Lys Pro Ser Gly Ala Val Asp Cys Asn Leu Glu Leu Phe Ser Leu Gln 
        515                 520                 525             


Ser Leu Asn Met Ser Leu Gln Asn Gln Leu Glu Glu Ser Leu Lys Ser 
    530                 535                 540                 


Gln Glu Leu Leu Gln Ser Lys Asn Glu Glu Leu Leu Lys Val Ile Glu 
545                 550                 555                 560 


Asn Gln Lys Asp Glu Asn Lys Lys Phe Ser Ser Ile Phe Lys Asp Lys 
                565                 570                 575     


Asp Gln Thr Ile Leu Glu Asn Lys Gln Gln Tyr Asp Ile Glu Ile Thr 
            580                 585                 590         


Arg Ile Lys Ile Glu Leu Glu Glu Ala Leu Val Asn Val Lys Ser Ser 
        595                 600                 605             


Gln Phe Lys Leu Glu Thr Ala Glu Lys Glu Asn Gln Ile Leu Gly Ile 
    610                 615                 620                 


Thr Leu Arg Gln Arg Asp Ala Glu Val Thr Arg Leu Arg Glu Leu Thr 
625                 630                 635                 640 


Arg Thr Leu Gln Thr Ser Met Ala Lys Leu Leu Ser Asp Leu Ser Val 
                645                 650                 655     


Asp Ser Ala Arg Cys Lys Pro Gly Asn Asn Leu Thr Lys Ser Leu Leu 
            660                 665                 670         


Asn Ile His Asp Lys Gln Leu Gln His Asp Pro Ala Pro Ala His Thr 
        675                 680                 685             


Ser Ile Met Ser Tyr Leu Asn Lys Leu Glu Thr Asn Tyr Ser Phe Thr 
    690                 695                 700                 


His Ser Glu Pro Leu Ser Thr Ile Lys Asn Glu Glu Thr Ile Glu Pro 
705                 710                 715                 720 


Asp Lys Thr Tyr Glu Asn Val Leu Ser Ser Arg Gly Pro Gln Asn Ser 
                725                 730                 735     


Asn Thr Arg Gly Met Glu Glu Ala Ser Ala Pro Gly Ile Ile Ser Ala 
            740                 745                 750         


Leu Ser Lys Gln Asp Ser Asp Glu Gly Ser Glu Thr Met Ala Leu Ile 
        755                 760                 765             


Glu Asp Glu His Asn Leu Asp Asn Thr Ile Tyr Ile Pro Phe Ala Arg 
    770                 775                 780                 


Ser Thr Pro Glu Lys Lys Ser Pro Leu Ser Lys Arg Leu Ser Pro Gln 
785                 790                 795                 800 


Pro Gln Ile Arg Ala Ala Thr Thr Gln Leu Val Ser Asn Ser Gly Leu 
                805                 810                 815     


Ala Val Ser Gly Lys Glu Asn Lys Leu Cys Thr Pro Val Ile Cys Ser 
            820                 825                 830         


Ser Ser Thr Lys Glu Ala Glu Asp Ala Pro Glu Lys Leu Ser Arg Ala 
        835                 840                 845             


Ser Asp Met Lys Asp Thr Gln Leu Leu Lys Lys Ile Lys Glu Ala Ile 
    850                 855                 860                 


Gly Lys Ile Pro Ala Ala Thr Lys Glu Pro Glu Glu Gln Thr Ala Cys 
865                 870                 875                 880 


His Gly Pro Ser Gly Cys Leu Ser Asn Ser Leu Gln Val Lys Gly Asn 
                885                 890                 895     


Thr Val Cys Asp Gly Ser Val Phe Thr Ser Asp Leu Met Ser Asp Trp 
            900                 905                 910         


Ser Ile Ser Ser Phe Ser Thr Phe Thr Ser Arg Asp Glu Gln Asp Phe 
        915                 920                 925             


Arg Asn Gly Leu Ala Ala Leu Asp Ala Asn Ile Ala Arg Leu Gln Lys 
    930                 935                 940                 


Ser Leu Arg Thr Gly Leu Leu Glu Lys 
945                 950             


<210> 8299
<211> 560
<212> PRT
<213> Homo sapiens

<400> 8299
Met Ser Glu His Ser Arg Asn Ser Asp Gln Glu Glu Leu Leu Asp Glu 
1               5                   10                  15      


Glu Ile Asn Glu Asp Glu Ile Leu Ala Asn Leu Ser Ala Glu Glu Leu 
            20                  25                  30          


Lys Glu Leu Gln Ser Glu Met Glu Val Met Ala Pro Asp Pro Ser Leu 
        35                  40                  45              


Pro Val Gly Met Ile Gln Lys Asp Gln Thr Asp Lys Pro Pro Thr Gly 
    50                  55                  60                  


Asn Phe Asn His Lys Ser Leu Val Asp Tyr Met Tyr Trp Glu Lys Ala 
65                  70                  75                  80  


Ser Arg Arg Met Leu Glu Glu Glu Arg Val Pro Val Thr Phe Val Lys 
                85                  90                  95      


Ser Glu Glu Lys Thr Gln Glu Glu His Glu Glu Ile Glu Lys Arg Asn 
            100                 105                 110         


Lys Asn Met Ala Gln Tyr Leu Lys Glu Lys Leu Asn Asn Glu Ile Val 
        115                 120                 125             


Ala Asn Lys Arg Glu Ser Lys Gly Ser Ser Asn Ile Gln Glu Thr Asp 
    130                 135                 140                 


Glu Glu Asp Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp Glu Gly Glu 
145                 150                 155                 160 


Asp Asp Gly Glu Glu Ser Glu Glu Thr Asn Arg Glu Glu Glu Gly Lys 
                165                 170                 175     


Ala Lys Glu Gln Ile Arg Asn Cys Glu Asn Asn Cys Gln Gln Val Thr 
            180                 185                 190         


Asp Lys Ala Phe Lys Glu Gln Arg Asp Arg Pro Glu Ala Gln Glu Gln 
        195                 200                 205             


Ser Glu Lys Lys Ile Ser Lys Leu Asp Pro Lys Lys Leu Ala Leu Asp 
    210                 215                 220                 


Thr Ser Phe Leu Lys Val Ser Thr Arg Pro Ser Gly Asn Gln Thr Asp 
225                 230                 235                 240 


Leu Asp Gly Ser Leu Arg Arg Val Arg Lys Asn Asp Pro Asp Met Lys 
                245                 250                 255     


Glu Leu Asn Leu Asn Asn Ile Glu Asn Ile Pro Lys Glu Met Leu Leu 
            260                 265                 270         


Asp Phe Val Asn Ala Met Lys Lys Asn Lys His Ile Lys Thr Phe Ser 
        275                 280                 285             


Leu Ala Asn Val Gly Ala Asp Glu Asn Val Ala Phe Ala Leu Ala Asn 
    290                 295                 300                 


Met Leu Arg Glu Asn Arg Ser Ile Thr Thr Leu Asn Ile Glu Ser Asn 
305                 310                 315                 320 


Phe Ile Thr Gly Lys Gly Ile Val Ala Ile Met Arg Cys Leu Gln Phe 
                325                 330                 335     


Asn Glu Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Met Leu 
            340                 345                 350         


Gly His His Ala Glu Met Glu Ile Ala Arg Leu Leu Lys Ala Asn Asn 
        355                 360                 365             


Thr Leu Leu Lys Met Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met 
    370                 375                 380                 


Val Val Thr Asn Leu Leu Thr Arg Asn Gln Asp Lys Gln Arg Gln Lys 
385                 390                 395                 400 


Arg Gln Glu Glu Gln Lys Gln Gln Gln Leu Lys Glu Gln Lys Lys Leu 
                405                 410                 415     


Ile Ala Met Leu Glu Asn Gly Leu Gly Leu Pro Pro Gly Met Trp Glu 
            420                 425                 430         


Leu Leu Gly Gly Pro Lys Pro Asp Ser Arg Met Gln Glu Phe Phe Gln 
        435                 440                 445             


Pro Pro Pro Pro Arg Pro Pro Asn Pro Gln Asn Val Pro Phe Ser Gln 
    450                 455                 460                 


Arg Ser Glu Met Met Lys Lys Pro Ser Gln Ala Pro Lys Tyr Arg Thr 
465                 470                 475                 480 


Asp Pro Asp Ser Phe Arg Val Val Lys Leu Lys Arg Ile Gln Arg Lys 
                485                 490                 495     


Ser Arg Met Pro Glu Ala Arg Glu Pro Pro Glu Lys Thr Asn Leu Lys 
            500                 505                 510         


Asp Val Ile Lys Thr Leu Lys Pro Val Pro Arg Asn Arg Pro Pro Pro 
        515                 520                 525             


Leu Val Glu Ile Thr Pro Arg Asp Gln Leu Leu Asn Asp Ile Arg His 
    530                 535                 540                 


Ser Ser Val Ala Tyr Leu Lys Pro Val Gln Leu Pro Lys Glu Leu Ala 
545                 550                 555                 560 


<210> 8300
<211> 50
<212> PRT
<213> Homo sapiens

<400> 8300
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Val Thr 
    50  


<210> 8301
<211> 95
<212> PRT
<213> Homo sapiens

<400> 8301
Met Ala Ile Gly Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys 
1               5                   10                  15      


Thr Gln Arg Leu Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro 
            20                  25                  30          


Ala Arg Val Trp Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg 
        35                  40                  45              


Val Pro His Thr Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro 
    50                  55                  60                  


Tyr Leu Ile Tyr Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr 
65                  70                  75                  80  


Ser Val Pro Ala Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg 
                85                  90                  95  


<210> 8302
<211> 419
<212> PRT
<213> Homo sapiens

<400> 8302
Met Ala Gly Ser Gly Cys Ala Trp Gly Ala Glu Pro Pro Arg Phe Leu 
1               5                   10                  15      


Glu Ala Phe Gly Arg Leu Trp Gln Val Gln Ser Arg Leu Gly Ser Gly 
            20                  25                  30          


Ser Ser Ala Ser Val Tyr Arg Val Arg Cys Cys Gly Asn Pro Gly Ser 
        35                  40                  45              


Pro Pro Gly Ala Leu Lys Gln Phe Leu Pro Pro Gly Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ser Ala Ala Glu Tyr Gly Phe Arg Lys Glu Arg Ala Ala Leu 
65                  70                  75                  80  


Glu Gln Leu Gln Gly His Arg Asn Ile Val Thr Leu Tyr Gly Val Phe 
                85                  90                  95      


Thr Ile His Phe Ser Pro Asn Val Pro Ser Arg Cys Leu Leu Leu Glu 
            100                 105                 110         


Leu Leu Asp Val Ser Val Ser Glu Leu Leu Leu Tyr Ser Ser His Gln 
        115                 120                 125             


Gly Cys Ser Met Trp Met Ile Gln His Cys Ala Arg Asp Val Leu Glu 
    130                 135                 140                 


Ala Leu Ala Phe Leu His His Glu Gly Tyr Val His Ala Asp Leu Lys 
145                 150                 155                 160 


Pro Arg Asn Ile Leu Trp Ser Ala Glu Asn Glu Cys Phe Lys Leu Ile 
                165                 170                 175     


Asp Phe Gly Leu Ser Phe Lys Glu Gly Asn Gln Asp Val Lys Tyr Ile 
            180                 185                 190         


Gln Thr Asp Gly Tyr Arg Ala Pro Glu Ala Glu Leu Gln Asn Cys Leu 
        195                 200                 205             


Ala Gln Ala Gly Leu Gln Ser Asp Thr Glu Cys Thr Ser Ala Val Asp 
    210                 215                 220                 


Leu Trp Ser Leu Gly Ile Ile Leu Leu Glu Met Phe Ser Gly Met Lys 
225                 230                 235                 240 


Leu Lys His Thr Val Arg Ser Gln Glu Trp Lys Ala Asn Ser Ser Ala 
                245                 250                 255     


Ile Ile Asp His Ile Phe Ala Ser Lys Ala Val Val Asn Ala Ala Ile 
            260                 265                 270         


Pro Ala Tyr His Leu Arg Asp Leu Ile Lys Ser Met Leu His Asp Asp 
        275                 280                 285             


Pro Ser Arg Arg Ile Pro Ala Glu Met Ala Leu Cys Ser Pro Phe Phe 
    290                 295                 300                 


Ser Ile Pro Phe Ala Pro His Ile Glu Asp Leu Val Met Leu Pro Thr 
305                 310                 315                 320 


Pro Val Leu Arg Leu Leu Asn Val Leu Asp Asp Asp Tyr Leu Glu Asn 
                325                 330                 335     


Glu Glu Glu Tyr Glu Asp Val Val Glu Asp Val Lys Glu Glu Cys Gln 
            340                 345                 350         


Lys Tyr Gly Pro Val Val Ser Leu Leu Val Pro Lys Glu Asn Pro Gly 
        355                 360                 365             


Arg Gly Gln Val Phe Val Glu Tyr Ala Asn Ala Gly Asp Ser Lys Ala 
    370                 375                 380                 


Ala Gln Lys Leu Leu Thr Gly Arg Met Phe Asp Gly Lys Phe Val Val 
385                 390                 395                 400 


Ala Thr Phe Tyr Pro Leu Ser Ala Tyr Lys Arg Gly Tyr Leu Tyr Gln 
                405                 410                 415     


Thr Leu Leu 
            


<210> 8303
<211> 423
<212> PRT
<213> Homo sapiens

<400> 8303
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu 
                165                 170                 175     


Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp 
            180                 185                 190         


Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp 
        195                 200                 205             


Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg 
    210                 215                 220                 


Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro 
225                 230                 235                 240 


Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp 
                245                 250                 255     


Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg 
            260                 265                 270         


Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Leu Asn Arg Val 
        275                 280                 285             


Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn Ile 
    290                 295                 300                 


Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys Asn 
305                 310                 315                 320 


His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala Glu 
                325                 330                 335     


Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile Asn 
            340                 345                 350         


Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys Asp 
        355                 360                 365             


Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile Glu 
    370                 375                 380                 


Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln Val 
385                 390                 395                 400 


Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Lys Leu Glu Lys 
                405                 410                 415     


Gln Leu Gln Lys Asp Lys Glu 
            420             


<210> 8304
<211> 370
<212> PRT
<213> Homo sapiens

<400> 8304
Met Glu Glu Gly Val Pro Cys Pro Ala Pro Ala Ala Lys Leu Thr Pro 
1               5                   10                  15      


Pro Val Lys Lys Ser Gln Asp Met His Asp Glu Arg Ser Lys Leu Val 
            20                  25                  30          


Asn Glu Tyr Ala Cys Arg Val Leu Glu Leu Leu Gly Met Gly His Arg 
        35                  40                  45              


Leu Phe Val Pro Arg Leu Leu Ala Thr Ser Lys Glu Asp Leu Leu Gln 
    50                  55                  60                  


Ala Asp Phe Glu Gly Ala Leu Lys Phe Phe Arg Val Gln Leu Pro Lys 
65                  70                  75                  80  


Arg Tyr Arg Ala Glu Glu Asn Ala Arg Arg Leu Met Glu Gln Ala Cys 
                85                  90                  95      


Asn Ile Lys Val Pro Thr Lys Lys Leu Lys Lys Tyr Glu Lys Glu Tyr 
            100                 105                 110         


Gln Thr Met Arg Glu Ser Gln Leu Gln Gln Glu Asp Pro Met Asp Arg 
        115                 120                 125             


Tyr Lys Arg Glu Asn Arg Arg Leu Gln Glu Ala Ser Met Arg Leu Glu 
    130                 135                 140                 


Gln Glu Asn Asp Asp Leu Ala His Glu Leu Val Thr Ser Lys Ile Ala 
145                 150                 155                 160 


Leu Arg Asn Asp Leu Asp Gln Ala Glu Asp Lys Ala Asp Val Leu Asn 
                165                 170                 175     


Lys Glu Leu Leu Leu Thr Lys Gln Arg Leu Val Glu Thr Glu Glu Glu 
            180                 185                 190         


Lys Arg Lys Gln Glu Glu Glu Thr Ala Gln Leu Lys Glu Val Phe Arg 
        195                 200                 205             


Lys Gln Leu Glu Lys Ala Glu Tyr Glu Ile Lys Lys Thr Thr Ala Ile 
    210                 215                 220                 


Ile Ala Glu Tyr Lys Gln Ile Cys Ser Gln Leu Ser Thr Arg Leu Glu 
225                 230                 235                 240 


Lys Gln Gln Ala Ala Ser Lys Glu Glu Leu Glu Val Val Lys Gly Lys 
                245                 250                 255     


Met Met Ala Cys Lys His Cys Ser Asp Ile Phe Ser Lys Glu Gly Ala 
            260                 265                 270         


Leu Lys Leu Ala Ala Thr Gly Arg Glu Asp Gln Gly Ile Glu Thr Asp 
        275                 280                 285             


Asp Glu Lys Asp Ser Leu Lys Lys Gln Leu Arg Glu Met Glu Leu Glu 
    290                 295                 300                 


Leu Ala Gln Thr Lys Leu Gln Leu Val Glu Ala Lys Cys Lys Ile Gln 
305                 310                 315                 320 


Glu Leu Glu His Gln Arg Gly Ala Leu Met Asn Glu Ile Gln Ala Ala 
                325                 330                 335     


Lys Asn Ser Trp Phe Ser Lys Thr Leu Asn Ser Ile Lys Thr Ala Thr 
            340                 345                 350         


Gly Thr Gln Pro Leu Gln Pro Ala Pro Val Thr Gln Pro Pro Lys Glu 
        355                 360                 365             


Ser Thr 
    370 


<210> 8305
<211> 753
<212> PRT
<213> Homo sapiens

<400> 8305
Met Tyr Ser Pro Ile Ile Tyr Gln Ala Leu Cys Glu His Val Gln Thr 
1               5                   10                  15      


Gln Met Ser Leu Met Asn Asp Leu Thr Ser Lys Asn Ile Pro Asn Gly 
            20                  25                  30          


Ile Pro Ala Val Pro Cys His Ala Pro Ser His Ser Glu Ser Gln Ala 
        35                  40                  45              


Thr Pro His Ser Ser Tyr Gly Leu Cys Thr Ser Thr Pro Val Trp Ser 
    50                  55                  60                  


Leu Gln Arg Pro Pro Cys Pro Pro Lys Val His Ser Glu Val Gln Thr 
65                  70                  75                  80  


Asp Gly Asn Ser Gln Phe Ala Ser Gln Gly Lys Thr Val Ser Ala Thr 
                85                  90                  95      


Cys Thr Asp Val Leu Arg Asn Ser Phe Asn Thr Ser Pro Gly Val Pro 
            100                 105                 110         


Cys Ser Leu Pro Lys Thr Asp Ile Ser Ala Ile Pro Thr Leu Gln Gln 
        115                 120                 125             


Leu Gly Leu Val Asn Gly Ile Leu Pro Gln Gln Gly Ile His Lys Glu 
    130                 135                 140                 


Thr Asp Leu Leu Lys Cys Ile Gln Thr Tyr Leu Ser Leu Phe Arg Ser 
145                 150                 155                 160 


His Gly Lys Glu Thr His Leu Asp Ser Gln Thr His Arg Ser Pro Thr 
                165                 170                 175     


Gln Ser Gln Pro Ala Phe Leu Ala Thr Asn Glu Glu Lys Cys Ala Arg 
            180                 185                 190         


Glu Gln Ile Arg Glu Ala Thr Ser Glu Arg Lys Asp Leu Asn Ile His 
        195                 200                 205             


Val Arg Asp Thr Lys Thr Val Lys Asp Val Gln Lys Ala Lys Asn Val 
    210                 215                 220                 


Asn Lys Thr Ala Glu Lys Val Arg Ile Ile Lys Tyr Leu Leu Gly Glu 
225                 230                 235                 240 


Leu Lys Ala Leu Val Ala Glu Gln Glu Asp Ser Glu Ile Gln Arg Leu 
                245                 250                 255     


Ile Thr Glu Met Glu Ala Cys Ile Ser Val Leu Pro Thr Val Ser Gly 
            260                 265                 270         


Asn Thr Asp Ile Gln Val Glu Ile Ala Leu Ala Met Gln Pro Leu Arg 
        275                 280                 285             


Ser Glu Asn Ala Gln Leu Arg Arg Gln Leu Arg Ile Leu Asn Gln Gln 
    290                 295                 300                 


Leu Arg Glu Gln Gln Lys Thr Gln Lys Pro Ser Gly Ala Val Asp Cys 
305                 310                 315                 320 


Asn Leu Glu Leu Phe Ser Leu Gln Ser Leu Asn Met Ser Leu Gln Asn 
                325                 330                 335     


Gln Leu Glu Glu Ser Leu Lys Ser Gln Glu Leu Leu Gln Ser Lys Asn 
            340                 345                 350         


Glu Glu Leu Leu Lys Val Ile Glu Asn Gln Lys Asp Glu Asn Lys Lys 
        355                 360                 365             


Phe Ser Ser Ile Phe Lys Asp Lys Asp Gln Thr Ile Leu Glu Asn Lys 
    370                 375                 380                 


Gln Gln Tyr Asp Ile Glu Ile Thr Arg Ile Lys Ile Glu Leu Glu Glu 
385                 390                 395                 400 


Ala Leu Val Asn Val Lys Ser Ser Gln Phe Lys Leu Glu Thr Ala Glu 
                405                 410                 415     


Lys Glu Asn Gln Ile Leu Gly Ile Thr Leu Arg Gln Arg Asp Ala Glu 
            420                 425                 430         


Val Thr Arg Leu Arg Glu Leu Thr Arg Thr Leu Gln Thr Ser Met Ala 
        435                 440                 445             


Lys Leu Leu Ser Asp Leu Ser Val Asp Ser Ala Arg Cys Lys Pro Gly 
    450                 455                 460                 


Asn Asn Leu Thr Lys Ser Leu Leu Asn Ile His Asp Lys Gln Leu Gln 
465                 470                 475                 480 


His Asp Pro Ala Pro Ala His Thr Ser Ile Met Ser Tyr Leu Asn Lys 
                485                 490                 495     


Leu Glu Thr Asn Tyr Ser Phe Thr His Ser Glu Pro Leu Ser Thr Ile 
            500                 505                 510         


Lys Asn Glu Glu Thr Ile Glu Pro Asp Lys Thr Tyr Glu Asn Val Leu 
        515                 520                 525             


Ser Ser Arg Gly Pro Gln Asn Ser Asn Thr Arg Gly Met Glu Glu Ala 
    530                 535                 540                 


Ser Ala Pro Gly Ile Ile Ser Ala Leu Ser Lys Gln Asp Ser Asp Glu 
545                 550                 555                 560 


Gly Ser Glu Thr Met Ala Leu Ile Glu Asp Glu His Asn Leu Asp Asn 
                565                 570                 575     


Thr Ile Tyr Ile Pro Phe Ala Arg Ser Thr Pro Glu Lys Lys Ser Pro 
            580                 585                 590         


Leu Ser Lys Arg Leu Ser Pro Gln Pro Gln Ile Arg Ala Ala Thr Thr 
        595                 600                 605             


Gln Leu Val Ser Asn Ser Gly Leu Ala Val Ser Gly Lys Glu Asn Lys 
    610                 615                 620                 


Leu Cys Thr Pro Val Ile Cys Ser Ser Ser Thr Lys Glu Ala Glu Asp 
625                 630                 635                 640 


Ala Pro Glu Lys Leu Ser Arg Ala Ser Asp Met Lys Asp Thr Gln Leu 
                645                 650                 655     


Leu Lys Lys Ile Lys Glu Ala Ile Gly Lys Ile Pro Ala Ala Thr Lys 
            660                 665                 670         


Glu Pro Glu Glu Gln Thr Ala Cys His Gly Pro Ser Gly Cys Leu Ser 
        675                 680                 685             


Asn Ser Leu Gln Val Lys Gly Asn Thr Val Cys Asp Gly Ser Val Phe 
    690                 695                 700                 


Thr Ser Asp Leu Met Ser Asp Trp Ser Ile Ser Ser Phe Ser Thr Phe 
705                 710                 715                 720 


Thr Ser Arg Asp Glu Gln Asp Phe Arg Asn Gly Leu Ala Ala Leu Asp 
                725                 730                 735     


Ala Asn Ile Ala Arg Leu Gln Lys Ser Leu Arg Thr Gly Leu Leu Glu 
            740                 745                 750         


Lys 
    


<210> 8306
<211> 688
<212> PRT
<213> Homo sapiens

<400> 8306
Met Ser Val Asn Ser Glu Lys Ser Ser Ser Ser Glu Arg Pro Glu Pro 
1               5                   10                  15      


Gln Gln Lys Ala Pro Leu Val Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Asp Pro Thr Pro Pro Glu Pro Glu Glu Glu 
        35                  40                  45              


Ile Leu Gly Ser Asp Asp Glu Glu Gln Glu Asp Pro Ala Asp Tyr Cys 
    50                  55                  60                  


Lys Gly Gly Tyr His Pro Val Lys Ile Gly Asp Leu Phe Asn Gly Arg 
65                  70                  75                  80  


Tyr His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp 
                85                  90                  95      


Leu Cys Trp Asp Met Gln Gly Lys Arg Phe Val Ala Met Lys Val Val 
            100                 105                 110         


Lys Ser Ala Gln His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Lys Leu 
        115                 120                 125             


Leu Lys Cys Val Arg Glu Ser Asp Pro Ser Asp Pro Asn Lys Asp Met 
    130                 135                 140                 


Val Val Gln Leu Ile Asp Asp Phe Lys Ile Ser Gly Met Asn Gly Ile 
145                 150                 155                 160 


His Val Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp 
                165                 170                 175     


Ile Ile Lys Ser Asn Tyr Gln Gly Leu Pro Val Arg Cys Val Lys Ser 
            180                 185                 190         


Ile Ile Arg Gln Val Leu Gln Gly Leu Asp Tyr Leu His Ser Lys Cys 
        195                 200                 205             


Lys Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Met Cys Val 
    210                 215                 220                 


Asp Asp Ala Tyr Val Arg Arg Met Ala Ala Glu Ala Thr Glu Trp Gln 
225                 230                 235                 240 


Lys Ala Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro 
                245                 250                 255     


Gln Gln Lys Pro Ile Gly Lys Ile Ser Lys Asn Lys Lys Lys Lys Leu 
            260                 265                 270         


Lys Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Leu Gln 
        275                 280                 285             


Glu Ile Glu Glu Leu Glu Arg Glu Ala Glu Arg Lys Ile Ile Glu Glu 
    290                 295                 300                 


Asn Ile Thr Ser Ala Ala Pro Ser Asn Asp Gln Asp Gly Glu Tyr Cys 
305                 310                 315                 320 


Pro Glu Val Lys Leu Lys Thr Thr Gly Leu Glu Glu Ala Ala Glu Ala 
                325                 330                 335     


Glu Thr Ala Lys Asp Asn Gly Glu Ala Glu Asp Gln Glu Glu Lys Glu 
            340                 345                 350         


Asp Ala Glu Lys Glu Asn Ile Glu Lys Asp Glu Asp Asp Val Asp Gln 
        355                 360                 365             


Glu Leu Ala Asn Ile Asp Pro Thr Trp Ile Glu Ser Pro Lys Thr Asn 
    370                 375                 380                 


Gly His Ile Glu Asn Gly Pro Phe Ser Leu Glu Gln Gln Leu Asp Asp 
385                 390                 395                 400 


Glu Asp Asp Asp Glu Glu Asp Cys Pro Asn Pro Glu Glu Tyr Asn Leu 
                405                 410                 415     


Asp Glu Pro Asn Ala Glu Ser Asp Tyr Thr Tyr Ser Ser Ser Tyr Glu 
            420                 425                 430         


Gln Phe Asn Gly Glu Leu Pro Asn Gly Arg His Lys Ile Pro Glu Ser 
        435                 440                 445             


Gln Phe Pro Glu Phe Ser Thr Ser Leu Phe Ser Gly Ser Leu Glu Pro 
    450                 455                 460                 


Val Ala Cys Gly Ser Val Leu Ser Glu Gly Ser Pro Leu Thr Glu Gln 
465                 470                 475                 480 


Glu Glu Ser Ser Pro Ser His Asp Arg Ser Arg Thr Val Ser Ala Ser 
                485                 490                 495     


Ser Thr Gly Asp Leu Pro Lys Ala Lys Thr Arg Ala Ala Asp Leu Leu 
            500                 505                 510         


Val Asn Pro Leu Asp Pro Arg Asn Ala Asp Lys Ile Arg Val Lys Ile 
        515                 520                 525             


Ala Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr Glu Asp 
    530                 535                 540                 


Ile Gln Thr Arg Gln Tyr Arg Ser Ile Glu Val Leu Ile Gly Ala Gly 
545                 550                 555                 560 


Tyr Ser Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu 
                565                 570                 575     


Leu Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly Glu Asp Tyr 
            580                 585                 590         


Ser Arg Asp Glu Asp His Ile Ala His Ile Ile Glu Leu Leu Gly Ser 
        595                 600                 605             


Ile Pro Arg His Phe Ala Leu Ser Gly Lys Tyr Ser Arg Glu Phe Phe 
    610                 615                 620                 


Asn Arg Arg Gly Glu Leu Arg His Ile Thr Lys Leu Lys Pro Trp Ser 
625                 630                 635                 640 


Leu Phe Asp Val Leu Val Glu Lys Tyr Gly Trp Pro His Glu Asp Ala 
                645                 650                 655     


Ala Gln Phe Thr Asp Phe Leu Ile Pro Met Leu Glu Met Val Pro Glu 
            660                 665                 670         


Lys Arg Ala Ser Ala Gly Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
        675                 680                 685             


<210> 8307
<211> 180
<212> PRT
<213> Homo sapiens

<400> 8307
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu 
                165                 170                 175     


Val Ile Pro Asn 
            180 


<210> 8308
<211> 1562
<212> PRT
<213> Homo sapiens

<400> 8308
Met Pro Gly Glu Ala Ala Arg Ala Glu Leu Leu Leu Pro Glu Ala Asp 
1               5                   10                  15      


Arg Pro Gly Pro Arg Thr Asp Leu Ser Cys Asp Ala Ala Ala Ala Thr 
            20                  25                  30          


Thr Ile Leu Gly Gly Asp Arg Arg Glu Pro Cys Ala Leu Thr Pro Gly 
        35                  40                  45              


Pro Ser His Leu Ala Leu Thr Phe Leu Pro Ser Lys Pro Gly Ala Arg 
    50                  55                  60                  


Pro Gln Pro Glu Gly Ala Ser Trp Asp Ala Gly Pro Gly Gly Ala Pro 
65                  70                  75                  80  


Ser Ala Trp Ala Asp Pro Gly Glu Gly Gly Pro Ser Pro Met Leu Leu 
                85                  90                  95      


Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr Glu Ala Pro Leu Pro 
            100                 105                 110         


Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu Glu Thr Cys Gln Ala 
        115                 120                 125             


Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu Arg Asp Gln Glu Gly 
    130                 135                 140                 


Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu Cys Ser Gln Gly Asp 
145                 150                 155                 160 


Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp Ser Phe Phe Thr Pro 
                165                 170                 175     


Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu Leu Pro Ala Cys Gly 
            180                 185                 190         


Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu Leu Arg Asp Glu Leu 
        195                 200                 205             


Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser Tyr Ile Thr Ala Asp 
    210                 215                 220                 


Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser Leu Ser Leu Leu Ala 
225                 230                 235                 240 


Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp Gly Leu Ser Pro Gln 
                245                 250                 255     


Gly Ser Met Val Asp Glu Arg Glu Leu His Pro Ala Gly Thr Pro Glu 
            260                 265                 270         


Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp Ser Ser Ser Ser Trp 
        275                 280                 285             


Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe Leu Ala Asn Asp Pro 
    290                 295                 300                 


Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly Ser Leu Ile Phe Gln 
305                 310                 315                 320 


Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro Glu Glu Glu Glu Glu 
                325                 330                 335     


Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp Leu Ala Gly Glu Gly 
            340                 345                 350         


Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln Ser Leu Ser Asp Leu 
        355                 360                 365             


Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala Phe Arg Asp Asp Thr 
    370                 375                 380                 


Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser Tyr Ala Glu Ala Asp 
385                 390                 395                 400 


Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala Gln Ala Thr Leu Leu 
                405                 410                 415     


Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser Gly Gly Gly Ala Lys 
            420                 425                 430         


Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp Ala Val Glu Ala Ala 
        435                 440                 445             


Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser Gln Arg Gln Glu Leu 
    450                 455                 460                 


Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu Gly Gln Glu Ser Thr 
465                 470                 475                 480 


Ala Thr Val Thr Pro His Thr Leu Gln Val Ala Pro Gly Leu Gln Val 
                485                 490                 495     


Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly Glu Glu Glu Thr Asp 
            500                 505                 510         


Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala Met Pro Gln Pro Ser 
        515                 520                 525             


Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu Ser Val Thr Ala Glu 
    530                 535                 540                 


Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu Thr Leu Cys Pro Asp 
545                 550                 555                 560 


Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu Asp Leu Pro Ser Gly 
                565                 570                 575     


Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro Arg Gln Ala Lys Glu 
            580                 585                 590         


Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu 
        595                 600                 605             


Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr 
    610                 615                 620                 


Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser 
625                 630                 635                 640 


Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Glu Leu Ser Ser Ala 
                645                 650                 655     


Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu 
            660                 665                 670         


Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu 
        675                 680                 685             


Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr 
    690                 695                 700                 


Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser 
705                 710                 715                 720 


Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala 
                725                 730                 735     


Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu 
            740                 745                 750         


Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu 
        755                 760                 765             


Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr 
    770                 775                 780                 


Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser 
785                 790                 795                 800 


Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala 
                805                 810                 815     


Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu 
            820                 825                 830         


Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu 
        835                 840                 845             


Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr 
    850                 855                 860                 


Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser 
865                 870                 875                 880 


Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala 
                885                 890                 895     


Pro Lys Pro Val Ala Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu 
            900                 905                 910         


Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Ala Pro Leu Pro Leu 
        915                 920                 925             


Gln Asp Thr Gly Pro Thr Ser Gly Pro Glu Pro Leu Ala Val Ala Thr 
    930                 935                 940                 


Pro Gln Thr Leu Gln Ala Glu Ala Gly Cys Ala Pro Gly Thr Glu Pro 
945                 950                 955                 960 


Val Ala Thr Met Ala Gln Gln Glu Val Gly Glu Ala Leu Gly Pro Arg 
                965                 970                 975     


Pro Ala Pro Glu Glu Lys Asn Ala Ala Leu Pro Thr Val Pro Glu Pro 
            980                 985                 990         


Ala Ala Leu Asp Gln Val Gln Gln  Asp Asp Pro Gln Pro  Ala Ala Glu 
        995                 1000                 1005             


Ala Gly  Thr Pro Trp Ala Ala  Gln Glu Asp Ala Asp  Ser Thr Leu 
    1010                 1015                 1020             


Gly Met  Glu Ala Leu Ser Leu  Pro Glu Pro Ala Ser  Gly Ala Gly 
    1025                 1030                 1035             


Glu Glu  Ile Ala Glu Ala Leu  Ser Arg Pro Gly Arg  Glu Ala Cys 
    1040                 1045                 1050             


Leu Glu  Ala Arg Ala His Thr  Gly Asp Gly Ala Lys  Pro Asp Ser 
    1055                 1060                 1065             


Pro Gln  Lys Glu Thr Leu Glu  Val Glu Asn Gln Gln  Glu Gly Gly 
    1070                 1075                 1080             


Leu Lys  Pro Leu Ala Gln Glu  His Gly Pro Arg Ser  Ala Leu Gly 
    1085                 1090                 1095             


Gly Ala  Arg Glu Val Pro Asp  Ala Pro Pro Ala Ala  Cys Pro Glu 
    1100                 1105                 1110             


Val Ser  Gln Ala Arg Leu Leu  Ser Pro Ala Arg Glu  Glu Arg Gly 
    1115                 1120                 1125             


Leu Ser  Gly Lys Ser Thr Pro  Glu Pro Thr Leu Pro  Ser Ala Val 
    1130                 1135                 1140             


Ala Thr  Glu Ala Ser Leu Asp  Ser Cys Pro Glu Ser  Ser Val Gly 
    1145                 1150                 1155             


Ala Val  Ser Ser Leu Asp Arg  Gly Cys Pro Asp Ala  Pro Ala Pro 
    1160                 1165                 1170             


Thr Ser  Ala Pro Thr Ser Gln  Gln Pro Glu Pro Val  Leu Gly Leu 
    1175                 1180                 1185             


Gly Ser  Val Glu Gln Pro His  Glu Val Pro Ser Val  Leu Gly Thr 
    1190                 1195                 1200             


Pro Leu  Leu Gln Pro Pro Glu  Asn Leu Ala Lys Gly  Gln Pro Ser 
    1205                 1210                 1215             


Thr Pro  Val Asp Arg Pro Leu  Gly Pro Asp Pro Ser  Ala Pro Gly 
    1220                 1225                 1230             


Thr Leu  Ala Gly Ala Ala Leu  Pro Pro Leu Glu Pro  Pro Ala Pro 
    1235                 1240                 1245             


Cys Leu  Cys Gln Asp Pro Gln  Glu Asp Ser Val Glu  Asp Glu Glu 
    1250                 1255                 1260             


Pro Pro  Gly Ser Leu Gly Leu  Pro Pro Pro Gln Ala  Gly Val Gln 
    1265                 1270                 1275             


Pro Ala  Ala Ala Ala Val Ser  Gly Thr Thr Gln Pro  Leu Gly Thr 
    1280                 1285                 1290             


Gly Pro  Arg Val Ser Leu Ser  Pro His Ser Pro Leu  Leu Ser Pro 
    1295                 1300                 1305             


Lys Val  Ala Ser Met Asp Ala  Lys Asp Leu Ala Leu  Gln Ile Leu 
    1310                 1315                 1320             


Pro Pro  Cys Gln Val Pro Pro  Pro Ser Gly Pro Gln  Ser Pro Ala 
    1325                 1330                 1335             


Gly Pro  Gln Gly Leu Ser Ala  Pro Glu Gln Gln Glu  Asp Glu Asp 
    1340                 1345                 1350             


Ser Leu  Glu Glu Asp Ser Pro  Arg Ala Leu Gly Ser  Gly Gln His 
    1355                 1360                 1365             


Ser Asp  Ser His Gly Glu Ser  Ser Ala Glu Leu Asp  Glu Gln Asp 
    1370                 1375                 1380             


Ile Leu  Ala Pro Gln Thr Val  Gln Cys Pro Ala Gln  Ala Pro Ala 
    1385                 1390                 1395             


Gly Gly  Ser Glu Glu Thr Ile  Ala Lys Ala Lys Gln  Ser Arg Ser 
    1400                 1405                 1410             


Glu Lys  Lys Ala Arg Lys Ala  Met Ser Lys Leu Gly  Leu Arg Gln 
    1415                 1420                 1425             


Ile Gln  Gly Val Thr Arg Ile  Thr Ile Gln Lys Ser  Lys Asn Ile 
    1430                 1435                 1440             


Leu Phe  Val Ile Ala Lys Pro  Asp Val Phe Lys Ser  Pro Ala Ser 
    1445                 1450                 1455             


Asp Thr  Tyr Val Val Phe Gly  Glu Ala Lys Ile Glu  Asp Leu Ser 
    1460                 1465                 1470             


Gln Gln  Val His Lys Ala Ala  Ala Glu Lys Phe Lys  Val Pro Ser 
    1475                 1480                 1485             


Glu Pro  Ser Ala Leu Val Pro  Glu Ser Ala Pro Arg  Pro Arg Val 
    1490                 1495                 1500             


Arg Leu  Glu Cys Lys Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Val 
    1505                 1510                 1515             


Asp Glu  Ala Gly Leu Glu Leu  Arg Asp Ile Glu Leu  Val Met Ala 
    1520                 1525                 1530             


Gln Ala  Asn Val Ser Arg Ala  Lys Ala Val Arg Ala  Leu Arg Asp 
    1535                 1540                 1545             


Asn His  Ser Asp Ile Val Asn  Ala Ile Met Glu Leu  Thr Met 
    1550                 1555                 1560         


<210> 8309
<211> 1097
<212> PRT
<213> Homo sapiens

<400> 8309
Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu Leu Gly 
1               5                   10                  15      


Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu Glu Thr 
            20                  25                  30          


Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu Gln Ala 
        35                  40                  45              


Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala Ala Val 
    50                  55                  60                  


Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr Pro Ala 
65                  70                  75                  80  


Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser Glu Leu Leu Met Ile 
                85                  90                  95      


Ile Gln Met Glu Thr Gln Ser Ser Met Arg Lys Lys Val Cys Asp Ile 
            100                 105                 110         


Ala Ala Glu Leu Ala Arg Asn Leu Ile Asp Glu Asp Gly Asn Asn Gln 
        115                 120                 125             


Trp Pro Glu Gly Leu Lys Phe Leu Phe Asp Ser Val Ser Ser Gln Asn 
    130                 135                 140                 


Val Gly Leu Arg Glu Ala Ala Leu His Ile Phe Trp Asn Phe Pro Gly 
145                 150                 155                 160 


Ile Phe Gly Asn Gln Gln Gln His Tyr Leu Asp Val Ile Lys Arg Met 
                165                 170                 175     


Leu Val Gln Cys Met Gln Asp Gln Glu His Pro Ser Ile Arg Thr Leu 
            180                 185                 190         


Ser Ala Arg Ala Thr Ala Ala Phe Ile Leu Ala Asn Glu His Asn Val 
        195                 200                 205             


Ala Leu Phe Lys His Phe Ala Asp Leu Leu Pro Gly Phe Leu Gln Ala 
    210                 215                 220                 


Val Asn Asp Ser Cys Tyr Gln Asn Asp Asp Ser Val Leu Lys Ser Leu 
225                 230                 235                 240 


Val Glu Ile Ala Asp Thr Val Pro Lys Tyr Leu Arg Pro His Leu Glu 
                245                 250                 255     


Ala Thr Leu Gln Leu Ser Leu Lys Leu Cys Gly Asp Thr Ser Leu Asn 
            260                 265                 270         


Asn Met Gln Arg Gln Leu Ala Leu Glu Val Ile Val Thr Leu Ser Glu 
        275                 280                 285             


Thr Ala Ala Ala Met Leu Arg Lys His Thr Asn Ile Val Ala Gln Thr 
    290                 295                 300                 


Ile Pro Gln Met Leu Ala Met Met Val Asp Leu Glu Glu Asp Glu Asp 
305                 310                 315                 320 


Trp Ala Asn Ala Asp Glu Leu Glu Asp Asp Asp Phe Asp Ser Asn Ala 
                325                 330                 335     


Val Ala Gly Glu Ser Ala Leu Asp Arg Met Ala Cys Gly Leu Gly Gly 
            340                 345                 350         


Lys Leu Val Leu Pro Met Ile Lys Glu His Ile Met Gln Met Leu Gln 
        355                 360                 365             


Asn Pro Asp Trp Lys Tyr Arg His Ala Gly Leu Met Ala Leu Ser Ala 
    370                 375                 380                 


Ile Gly Glu Gly Cys His Gln Gln Met Glu Gly Ile Leu Asn Glu Ile 
385                 390                 395                 400 


Val Asn Phe Val Leu Leu Phe Leu Gln Asp Pro His Pro Arg Val Arg 
                405                 410                 415     


Tyr Ala Ala Cys Asn Ala Val Gly Gln Met Ala Thr Asp Phe Ala Pro 
            420                 425                 430         


Gly Phe Gln Lys Lys Phe His Glu Lys Val Ile Ala Ala Leu Leu Gln 
        435                 440                 445             


Thr Met Glu Asp Gln Gly Asn Gln Arg Val Gln Ala His Ala Ala Ala 
    450                 455                 460                 


Ala Leu Ile Asn Phe Thr Glu Asp Cys Pro Lys Ser Leu Leu Ile Pro 
465                 470                 475                 480 


Tyr Leu Asp Asn Leu Val Lys His Leu His Ser Ile Met Val Leu Lys 
                485                 490                 495     


Leu Gln Glu Leu Ile Gln Lys Gly Thr Lys Leu Val Leu Glu Gln Val 
            500                 505                 510         


Val Thr Ser Ile Ala Ser Val Ala Asp Thr Ala Glu Glu Lys Phe Val 
        515                 520                 525             


Pro Tyr Tyr Asp Leu Phe Met Pro Ser Leu Lys His Ile Val Glu Asn 
    530                 535                 540                 


Ala Val Gln Lys Glu Leu Arg Leu Leu Arg Gly Lys Thr Ile Glu Cys 
545                 550                 555                 560 


Ile Ser Leu Ile Gly Leu Ala Val Gly Lys Glu Lys Phe Met Gln Asp 
                565                 570                 575     


Ala Ser Asp Val Met Gln Leu Leu Leu Lys Thr Gln Thr Asp Phe Asn 
            580                 585                 590         


Asp Met Glu Asp Asp Asp Pro Gln Ile Ser Tyr Met Ile Ser Ala Trp 
        595                 600                 605             


Ala Arg Met Cys Lys Ile Leu Gly Lys Glu Phe Gln Gln Tyr Leu Pro 
    610                 615                 620                 


Val Val Met Gly Pro Leu Met Lys Thr Ala Ser Ile Lys Pro Glu Val 
625                 630                 635                 640 


Ala Leu Leu Asp Thr Gln Asp Met Glu Asn Met Ser Asp Asp Asp Gly 
                645                 650                 655     


Trp Glu Phe Val Asn Leu Gly Asp Gln Gln Ser Phe Gly Ile Lys Thr 
            660                 665                 670         


Ala Gly Leu Glu Glu Lys Ser Thr Ala Cys Gln Met Leu Val Cys Tyr 
        675                 680                 685             


Ala Lys Glu Leu Lys Glu Gly Phe Val Glu Tyr Thr Glu Gln Val Val 
    690                 695                 700                 


Lys Leu Met Val Pro Leu Leu Lys Phe Tyr Phe His Asp Gly Val Arg 
705                 710                 715                 720 


Val Ala Ala Ala Glu Ser Met Pro Leu Leu Leu Glu Cys Ala Arg Val 
                725                 730                 735     


Arg Gly Pro Glu Tyr Leu Thr Gln Met Trp His Phe Met Cys Asp Ala 
            740                 745                 750         


Leu Ile Lys Ala Ile Gly Thr Glu Pro Asp Ser Asp Val Leu Ser Glu 
        755                 760                 765             


Ile Met His Ser Phe Ala Lys Cys Ile Glu Val Met Gly Asp Gly Cys 
    770                 775                 780                 


Leu Asn Asn Glu His Phe Glu Glu Leu Gly Gly Ile Leu Lys Ala Lys 
785                 790                 795                 800 


Leu Glu Glu His Phe Lys Asn Gln Glu Leu Arg Gln Val Lys Arg Gln 
                805                 810                 815     


Asp Glu Asp Tyr Asp Glu Gln Val Glu Glu Ser Leu Gln Asp Glu Asp 
            820                 825                 830         


Asp Asn Asp Val Tyr Ile Leu Thr Lys Val Ser Asp Ile Leu His Ser 
        835                 840                 845             


Ile Phe Ser Ser Tyr Lys Glu Lys Val Leu Pro Trp Phe Glu Gln Leu 
    850                 855                 860                 


Leu Pro Leu Ile Val Asn Leu Ile Cys Pro His Arg Pro Trp Pro Asp 
865                 870                 875                 880 


Arg Gln Trp Gly Leu Cys Ile Phe Asp Asp Val Ile Glu His Cys Ser 
                885                 890                 895     


Pro Ala Ser Phe Lys Tyr Ala Glu Tyr Phe Leu Arg Pro Met Leu Gln 
            900                 905                 910         


Tyr Val Cys Asp Asn Ser Pro Glu Val Arg Gln Ala Ala Ala Tyr Gly 
        915                 920                 925             


Leu Gly Val Met Ala Gln Tyr Gly Gly Asp Asn Tyr Arg Pro Phe Cys 
    930                 935                 940                 


Thr Glu Ala Leu Pro Leu Leu Val Arg Val Ile Gln Ser Ala Asp Ser 
945                 950                 955                 960 


Lys Thr Lys Glu Asn Val Asn Ala Thr Glu Asn Cys Ile Ser Ala Val 
                965                 970                 975     


Gly Lys Ile Met Lys Phe Lys Pro Asp Cys Val Asn Val Glu Glu Val 
            980                 985                 990         


Leu Pro His Trp Leu Ser Trp Leu  Pro Leu His Glu Asp  Lys Glu Glu 
        995                 1000                 1005             


Ala Val  Gln Thr Phe Asn Tyr  Leu Cys Asp Leu Ile  Glu Ser Asn 
    1010                 1015                 1020             


His Pro  Ile Val Leu Gly Pro  Asn Asn Thr Asn Leu  Pro Lys Ile 
    1025                 1030                 1035             


Phe Ser  Ile Ile Ala Glu Gly  Glu Met His Glu Ala  Ile Lys His 
    1040                 1045                 1050             


Glu Asp  Pro Cys Ala Lys Arg  Leu Ala Asn Val Val  Arg Gln Val 
    1055                 1060                 1065             


Gln Thr  Ser Gly Gly Leu Trp  Thr Glu Cys Ile Ala  Gln Leu Ser 
    1070                 1075                 1080             


Pro Glu  Gln Gln Ala Ala Ile  Gln Glu Leu Leu Asn  Ser Ala 
    1085                 1090                 1095         


<210> 8310
<211> 336
<212> PRT
<213> Homo sapiens

<400> 8310
Met Lys Ala Thr Ala Met Thr Ser Ala Trp Leu Ala Gln Gly Gly Ala 
1               5                   10                  15      


His Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys 
            20                  25                  30          


Ile Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His 
        35                  40                  45              


Lys Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly 
    50                  55                  60                  


Ser Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly 
65                  70                  75                  80  


Lys Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg 
                85                  90                  95      


Leu Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln 
            100                 105                 110         


Glu Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg 
        115                 120                 125             


Tyr Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu 
    130                 135                 140                 


Gln Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala 
145                 150                 155                 160 


Val His Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr 
                165                 170                 175     


Thr Ser Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu 
            180                 185                 190         


Gln Lys Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala 
        195                 200                 205             


Ala Ala Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala 
    210                 215                 220                 


Pro Ser Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr 
225                 230                 235                 240 


Glu Glu Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val 
                245                 250                 255     


Gln Gln Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly 
            260                 265                 270         


Gln Gly Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr 
        275                 280                 285             


Gln Ala Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile 
    290                 295                 300                 


Thr Gly Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro 
305                 310                 315                 320 


Asp Gly His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
                325                 330                 335     


<210> 8311
<211> 25
<212> PRT
<213> Homo sapiens

<400> 8311
Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met Val 
1               5                   10                  15      


Gly Ala Ile Arg Asn Ala Ala Phe Leu 
            20                  25  


<210> 8312
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8312
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Phe Leu Arg Thr Ile Pro Asp Pro Gly 
                85                  90                  95      


Asp Val Pro Asp Ser Phe Phe 
            100             


<210> 8313
<211> 1366
<212> PRT
<213> Homo sapiens

<400> 8313
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Ala Gly Asn Pro Leu Val Gln 
        35                  40                  45              


Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn Pro Ala Pro Gly Leu 
    50                  55                  60                  


Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro Val Gln Val Met Gln 
65                  70                  75                  80  


Asn Ala Asn His Val Thr Ser Ser Pro Val Ala Ser Gln Pro Ile Phe 
                85                  90                  95      


Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val Arg Pro Val Gln Asn 
            100                 105                 110         


Ala Met Asn Gln Val Gly Ile Val Leu Asn Val Gln Gln Gly Gln Thr 
        115                 120                 125             


Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly Thr Gln Phe Val Lys 
    130                 135                 140                 


Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln Met Thr Pro Val Arg 
145                 150                 155                 160 


Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr Asn Thr Phe Thr Thr 
                165                 170                 175     


Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr Val Pro Gln Ser Gln 
            180                 185                 190         


Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser Thr Thr Pro Thr Ala 
        195                 200                 205             


Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val Gln Ser Pro Gly Gln 
    210                 215                 220                 


Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro Ser Phe Pro Ser Pro 
225                 230                 235                 240 


Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val Lys Arg Pro Gly Val 
                245                 250                 255     


Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu Val Asn Thr Leu Asn 
            260                 265                 270         


Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro Val Val Val Ser Asn 
        275                 280                 285             


Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser Gly Pro Glu Ser Ser 
    290                 295                 300                 


Met Lys Val Thr Ser Ser Ile Pro Val Phe Asp Leu Gln Asp Gly Gly 
305                 310                 315                 320 


Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln Phe Arg Val Thr Glu Ala 
                325                 330                 335     


Leu Arg Gly His Met Cys Tyr Cys Cys Pro Glu Met Val Glu Tyr Gln 
            340                 345                 350         


Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro Ser Val Pro Ser Ala Ala 
        355                 360                 365             


Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro Val Ala Ser Thr Pro Ser 
    370                 375                 380                 


Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro Thr Lys Val Pro Glu Pro 
385                 390                 395                 400 


Asn Glu Asn Val Gly Asp Ala Val Gln Thr Lys Leu Ile Met Leu Val 
                405                 410                 415     


Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly Lys Val Ala Gln Leu Thr 
            420                 425                 430         


Asn Phe Pro Lys Val Ala Thr Ser Phe Arg Cys Pro His Cys Thr Lys 
        435                 440                 445             


Arg Leu Lys Asn Asn Ile Arg Phe Met Asn His Met Lys His His Val 
    450                 455                 460                 


Glu Leu Asp Gln Gln Asn Gly Glu Val Asp Gly His Thr Ile Cys Gln 
465                 470                 475                 480 


His Cys Tyr Arg Gln Phe Ser Thr Pro Phe Gln Leu Gln Cys His Leu 
                485                 490                 495     


Glu Asn Val His Ser Pro Tyr Glu Ser Thr Thr Lys Cys Lys Ile Cys 
            500                 505                 510         


Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe Leu Gln His Met Lys Asp 
        515                 520                 525             


Thr His Lys Pro Gly Glu Met Pro Tyr Val Cys Gln Pro Tyr Phe Pro 
    530                 535                 540                 


Ser Tyr Val Thr Gln Val Cys Gln Tyr Arg Ser Ser Leu Tyr Ser Glu 
545                 550                 555                 560 


Val Asp Val His Phe Arg Met Ile His Glu Asp Thr Arg His Leu Leu 
                565                 570                 575     


Cys Pro Tyr Cys Leu Lys Val Phe Lys Asn Gly Asn Ala Phe Gln Gln 
            580                 585                 590         


His Tyr Met Arg His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys 
        595                 600                 605             


Arg Leu Gln Phe Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln 
    610                 615                 620                 


His His Lys Thr Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Lys Val Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val 
                645                 650                 655     


Pro Val Ser Ser Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala 
            660                 665                 670         


Pro Leu Thr Ser Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro 
        675                 680                 685             


Val Gln Arg Ser Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met 
    690                 695                 700                 


Gly Arg Gln Thr Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro 
705                 710                 715                 720 


Asn His Phe Pro Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr 
                725                 730                 735     


Cys Cys Ser Arg Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro 
            740                 745                 750         


Arg Lys Ser Pro Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly 
        755                 760                 765             


Ile Lys Leu Ala Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp 
    770                 775                 780                 


Ala Met Ala Lys His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser 
785                 790                 795                 800 


Ile Leu Pro Arg Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln 
                805                 810                 815     


Thr Arg Asp Arg Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro 
            820                 825                 830         


Pro Ser Phe Pro Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala 
        835                 840                 845             


Thr Pro Ala Glu Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu 
    850                 855                 860                 


Pro Ser Pro Ala Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro 
865                 870                 875                 880 


Gln Ala Leu Ala Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu 
                885                 890                 895     


Asn Val Asp Asp Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu 
            900                 905                 910         


Leu Ala Ser Gly Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln 
        915                 920                 925             


Leu Ser Val Lys Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn 
    930                 935                 940                 


Thr Glu Gln Ala Ala Glu His Phe Arg Asn Pro Gln Arg Arg Ile Arg 
945                 950                 955                 960 


Arg Trp Leu Arg Arg Phe Gln Ala Ser Gln Gly Glu Asn Leu Glu Gly 
                965                 970                 975     


Lys Tyr Leu Ser Phe Glu Ala Glu Glu Lys Leu Ala Glu Trp Val Leu 
            980                 985                 990         


Thr Gln Arg Glu Gln Gln Leu Pro  Val Asn Glu Glu Thr  Leu Phe Gln 
        995                 1000                 1005             


Lys Ala  Thr Lys Ile Gly Arg  Ser Leu Glu Gly Gly  Phe Lys Ile 
    1010                 1015                 1020             


Ser Tyr  Glu Trp Ala Val Arg  Phe Met Leu Arg His  His Leu Thr 
    1025                 1030                 1035             


Pro His  Ala Arg Arg Ala Val  Ala His Thr Leu Pro  Lys Asp Val 
    1040                 1045                 1050             


Ala Glu  Asn Ala Gly Leu Phe  Ile Asp Phe Val Gln  Arg Gln Ile 
    1055                 1060                 1065             


His Asn  Gln Asp Leu Pro Leu  Ser Met Ile Val Ala  Ile Asp Glu 
    1070                 1075                 1080             


Ile Ser  Leu Phe Leu Asp Thr  Glu Val Leu Ser Ser  Asp Asp Arg 
    1085                 1090                 1095             


Lys Glu  Asn Ala Leu Gln Thr  Val Gly Thr Gly Glu  Pro Trp Cys 
    1100                 1105                 1110             


Asp Val  Val Leu Ala Ile Leu  Ala Asp Gly Thr Val  Leu Pro Thr 
    1115                 1120                 1125             


Leu Val  Phe Tyr Arg Gly Gln  Met Asp Gln Pro Ala  Asn Met Pro 
    1130                 1135                 1140             


Asp Ser  Ile Leu Leu Glu Ala  Lys Glu Ser Gly Tyr  Ser Asp Asp 
    1145                 1150                 1155             


Glu Ile  Met Glu Leu Trp Ser  Thr Arg Val Trp Gln  Lys His Thr 
    1160                 1165                 1170             


Ala Cys  Gln Arg Ser Lys Gly  Met Leu Val Met Asp  Cys His Arg 
    1175                 1180                 1185             


Thr His  Leu Ser Glu Glu Val  Leu Ala Met Leu Ser  Ala Ser Ser 
    1190                 1195                 1200             


Thr Leu  Pro Ala Val Val Pro  Ala Gly Cys Ser Ser  Lys Ile Gln 
    1205                 1210                 1215             


Pro Leu  Asp Val Cys Ile Lys  Arg Thr Val Lys Asn  Phe Leu His 
    1220                 1225                 1230             


Lys Lys  Trp Lys Glu Gln Ala  Arg Glu Met Ala Asp  Thr Ala Cys 
    1235                 1240                 1245             


Asp Ser  Asp Val Leu Leu Gln  Leu Val Leu Val Trp  Leu Gly Glu 
    1250                 1255                 1260             


Val Leu  Gly Val Ile Gly Asp  Cys Pro Glu Leu Val  Gln Arg Ser 
    1265                 1270                 1275             


Phe Leu  Val Ala Ser Val Leu  Pro Gly Pro Asp Gly  Asn Ile Asn 
    1280                 1285                 1290             


Ser Pro  Thr Arg Asn Ala Asp  Met Gln Glu Glu Leu  Ile Ala Ser 
    1295                 1300                 1305             


Leu Glu  Glu Gln Leu Lys Leu  Ser Gly Glu His Ser  Glu Ser Ser 
    1310                 1315                 1320             


Thr Pro  Arg Pro Arg Ser Ser  Pro Glu Glu Thr Ile  Glu Pro Glu 
    1325                 1330                 1335             


Ser Leu  His Gln Leu Phe Glu  Gly Glu Ser Glu Thr  Glu Ser Phe 
    1340                 1345                 1350             


Tyr Gly  Phe Glu Glu Ala Asp  Leu Asp Leu Met Glu  Ile 
    1355                 1360                 1365     


<210> 8314
<211> 187
<212> PRT
<213> Homo sapiens

<400> 8314
Met Asp Ile Ser Lys Gly Leu Pro Gly Met Gln Gly Gly Leu His Ile 
1               5                   10                  15      


Trp Ile Ser Glu Asn Arg Lys Met Val Pro Val Pro Glu Gly Ala Tyr 
            20                  25                  30          


Gly Asn Phe Phe Glu Glu His Cys Tyr Val Ile Leu His Val Pro Gln 
        35                  40                  45              


Ser Pro Lys Ala Thr Gln Gly Ala Ser Ser Asp Leu His Tyr Trp Val 
    50                  55                  60                  


Gly Lys Gln Ala Gly Ala Glu Ala Gln Gly Ala Ala Glu Ala Phe Gln 
65                  70                  75                  80  


Gln Arg Leu Gln Asp Glu Leu Gly Gly Gln Thr Val Leu His Arg Glu 
                85                  90                  95      


Ala Gln Gly His Glu Ser Asp Cys Phe Cys Ser Tyr Phe Arg Pro Gly 
            100                 105                 110         


Ile Ile Tyr Arg Lys Gly Gly Leu Ala Ser Asp Leu Lys His Val Glu 
        115                 120                 125             


Thr Asn Leu Phe Asn Ile Gln Arg Leu Leu His Ile Lys Gly Arg Lys 
    130                 135                 140                 


His Val Ser Ala Thr Glu Val Glu Leu Ser Trp Asn Ser Phe Asn Lys 
145                 150                 155                 160 


Gly Asp Ile Phe Leu Leu Asp Leu Gly Lys Met Met Ile Gln Trp Asn 
                165                 170                 175     


Gly Pro Lys Thr Ser Ile Ser Glu Lys Ala Arg 
            180                 185         


<210> 8315
<211> 442
<212> PRT
<213> Homo sapiens

<400> 8315
Met Pro Leu Glu Asn Leu Glu Glu Glu Gly Leu Pro Lys Asn Pro Asp 
1               5                   10                  15      


Leu Arg Ile Ala Gln Leu Arg Phe Leu Leu Ser Leu Pro Glu His Arg 
            20                  25                  30          


Gly Asp Ala Ala Val Arg Asp Glu Leu Met Ala Ala Val Arg Asp Asn 
        35                  40                  45              


Asn Phe Trp Asn Arg Ile Arg Gln Glu Gln Thr Glu Asp Cys Pro Pro 
    50                  55                  60                  


Ser Ser Pro Ser Arg Gly Trp His Cys Gln Asp Trp Pro Ser Arg Lys 
65                  70                  75                  80  


Pro Pro Thr Ser Ile Arg Leu Cys Phe Ala Lys Pro Ile Ile Lys Arg 
                85                  90                  95      


His Arg Met Pro Ser Tyr Met Ala Pro Tyr Tyr Glu Ala Leu Cys Lys 
            100                 105                 110         


Ser Leu Asp Trp Gln Ile Asp Val Asp Leu Leu Asn Lys Met Lys Lys 
        115                 120                 125             


Ala Asn Glu Asp Glu Leu Lys Arg Leu Asp Glu Glu Leu Glu Asp Ala 
    130                 135                 140                 


Glu Lys Asn Leu Gly Glu Ser Glu Ile Arg Asp Ala Met Met Ala Lys 
145                 150                 155                 160 


Ala Glu Tyr Leu Cys Arg Ile Gly Asp Lys Glu Gly Ala Leu Thr Ala 
                165                 170                 175     


Phe Arg Lys Thr Tyr Asp Lys Thr Val Ala Leu Gly His Arg Leu Asp 
            180                 185                 190         


Ile Val Phe Tyr Leu Leu Arg Ile Gly Leu Phe Tyr Met Asp Asn Asp 
        195                 200                 205             


Leu Ile Thr Arg Asn Thr Glu Lys Ala Lys Ser Leu Ile Glu Glu Gly 
    210                 215                 220                 


Gly Asp Trp Asp Arg Arg Asn Arg Leu Lys Val Tyr Gln Gly Leu Tyr 
225                 230                 235                 240 


Cys Val Ala Ile Arg Asp Phe Lys Gln Ala Ala Glu Leu Phe Leu Asp 
                245                 250                 255     


Thr Val Ser Thr Phe Thr Ser Tyr Glu Leu Met Asp Tyr Lys Thr Phe 
            260                 265                 270         


Val Thr Tyr Thr Val Tyr Val Ser Met Ile Ala Leu Glu Arg Pro Asp 
        275                 280                 285             


Leu Arg Glu Lys Val Ile Lys Gly Ala Glu Ile Leu Glu Val Leu His 
    290                 295                 300                 


Ser Leu Pro Ala Val Arg Gln Tyr Leu Phe Ser Leu Tyr Glu Cys Arg 
305                 310                 315                 320 


Tyr Ser Val Phe Phe Gln Ser Leu Ala Val Val Glu Gln Glu Met Lys 
                325                 330                 335     


Lys Asp Trp Leu Phe Ala Pro His Tyr Arg Tyr Tyr Val Arg Glu Met 
            340                 345                 350         


Arg Ile His Ala Tyr Ser Gln Leu Leu Glu Ser Tyr Arg Ser Leu Thr 
        355                 360                 365             


Leu Gly Tyr Met Ala Glu Ala Phe Gly Val Gly Val Glu Phe Ile Asp 
    370                 375                 380                 


Gln Glu Leu Ser Arg Phe Ile Ala Ala Gly Arg Leu His Cys Lys Ile 
385                 390                 395                 400 


Asp Lys Val Asn Glu Ile Val Glu Thr Asn Arg Pro Asp Ser Lys Asn 
                405                 410                 415     


Trp Gln Tyr Gln Glu Thr Ile Lys Lys Gly Asp Leu Leu Leu Asn Arg 
            420                 425                 430         


Val Gln Lys Leu Ser Arg Val Ile Asn Met 
        435                 440         


<210> 8316
<211> 110
<212> PRT
<213> Homo sapiens

<400> 8316
Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Phe Arg Ser Cys 
65                  70                  75                  80  


Phe Pro Gly Arg Ser Ala Met Ala Pro Ser Arg Leu Thr Ala Thr Ser 
                85                  90                  95      


Ala Ser Gln Val Gln Ala Ile Leu Leu Pro Gln Pro Pro Glu 
            100                 105                 110 


<210> 8317
<211> 309
<212> PRT
<213> Homo sapiens

<400> 8317
Met Val Cys Trp Gln Ser Val Ser Val Trp Ser Val Ala Gly Arg Val 
1               5                   10                  15      


Glu Met Thr Val Ser Lys Phe Met Ala Ile Gln Lys Ala Leu Gln Pro 
            20                  25                  30          


Asp Trp Phe Gln Cys Leu Ser Asp Gly Glu Val Ser Cys Lys Glu Ala 
        35                  40                  45              


Thr Ser Ile Lys Arg Val Arg Lys Ser Val Asp Arg Ser Leu Leu Phe 
    50                  55                  60                  


Leu Asp Asn Cys Leu Arg Leu Gln Glu Glu Ser Glu Val Leu Gln Lys 
65                  70                  75                  80  


Ser Val Ile Ile Gly Val Ile Glu Gly Gly Asp Val Met Glu Glu Arg 
                85                  90                  95      


Leu Arg Ser Ala Arg Glu Thr Ala Lys Arg Pro Val Gly Gly Phe Leu 
            100                 105                 110         


Leu Asp Gly Phe Gln Gly Asn Pro Thr Thr Leu Glu Ala Arg Leu Arg 
        115                 120                 125             


Leu Leu Ser Ser Val Thr Ala Glu Leu Pro Glu Asp Lys Pro Arg Leu 
    130                 135                 140                 


Ile Ser Gly Val Ser Arg Pro Asp Glu Val Leu Glu Cys Ile Glu Arg 
145                 150                 155                 160 


Gly Val Asp Leu Phe Glu Ser Phe Phe Pro Tyr Gln Val Thr Glu Arg 
                165                 170                 175     


Gly Cys Ala Leu Thr Phe Ser Phe Asp Tyr Gln Pro Asn Pro Glu Glu 
            180                 185                 190         


Thr Leu Leu Gln Gln Asn Gly Thr Gln Glu Glu Ile Lys Cys Met Asp 
        195                 200                 205             


Gln Ile Lys Lys Ile Glu Thr Thr Gly Cys Asn Gln Glu Ile Thr Ser 
    210                 215                 220                 


Phe Glu Ile Asn Leu Lys Glu Lys Lys Tyr Gln Glu Asp Phe Asn Pro 
225                 230                 235                 240 


Leu Val Arg Gly Cys Ser Cys Tyr Cys Cys Lys Asn His Thr Arg Ala 
                245                 250                 255     


Tyr Ile His His Leu Leu Val Thr Asn Glu Leu Leu Ala Gly Val Leu 
            260                 265                 270         


Leu Met Met His Asn Phe Glu His Tyr Phe Gly Phe Phe His Tyr Ile 
        275                 280                 285             


Arg Glu Ala Leu Lys Ser Asp Lys Leu Ala Gln Leu Lys Glu Leu Ile 
    290                 295                 300                 


His Arg Gln Ala Ser 
305                 


<210> 8318
<211> 127
<212> PRT
<213> Homo sapiens

<400> 8318
Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met Glu Cys Phe Leu Gln Tyr Val Tyr Thr Gly 
        115                 120                 125         


<210> 8319
<211> 526
<212> PRT
<213> Homo sapiens

<400> 8319
Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Phe Pro 
        35                  40                  45              


Ile Ser Lys Pro Asp Gly Ile Ser Gln Leu Glu Gln Asp Leu Gln Val 
    50                  55                  60                  


Phe Asp Leu Glu Thr Lys Thr Arg Glu Val Leu Arg Asp Asp Cys Ser 
65                  70                  75                  80  


Asp Gly Glu Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys 
                85                  90                  95      


Ile Ser Glu Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys 
            100                 105                 110         


His Asp Ile Thr Gln Val Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu 
        115                 120                 125             


Asp Arg Leu Glu Arg Leu Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu 
    130                 135                 140                 


Glu Arg Glu Phe Arg Gln Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser 
145                 150                 155                 160 


Glu Lys Asn Asn Glu Cys His Glu Pro Glu Lys Ser Phe Ser Leu Asp 
                165                 170                 175     


Ser Thr Ile Asp Ala Asp Gln Arg Val Leu Arg Ile Gln Asn Thr Asp 
            180                 185                 190         


Asp Asn Asp Lys Tyr Asp Met Ser Phe Asn Gln Asn Ser Ala Ser Gly 
        195                 200                 205             


Lys His Glu His Leu Asn Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys 
    210                 215                 220                 


Lys Glu Ser Leu Met Asp Leu Ser His Leu Asn Lys Trp Glu Ser Ile 
225                 230                 235                 240 


Pro Asn Thr Glu Lys Ser Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe 
                245                 250                 255     


His Gln Ser Ser Ala Leu Thr Arg His Gln Arg Ile His Thr Arg Glu 
            260                 265                 270         


Lys Pro Tyr Lys Cys Lys Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser 
        275                 280                 285             


Ser Leu Ser Arg His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys 
    290                 295                 300                 


Cys Glu Ala Ser Asp Lys Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser 
305                 310                 315                 320 


Pro Ser Ser Gly Ile Ile Gln His Lys Lys Ile His Thr Arg Ala Lys 
                325                 330                 335     


Ser Tyr Lys Cys Ser Ser Cys Glu Arg Val Phe Ser Arg Ser Val His 
            340                 345                 350         


Leu Thr Gln His Gln Lys Ile His Lys Glu Met Pro Cys Lys Cys Thr 
        355                 360                 365             


Val Cys Gly Ser Asp Phe Cys His Thr Ser Tyr Leu Leu Glu His Gln 
    370                 375                 380                 


Arg Val His His Glu Glu Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu 
385                 390                 395                 400 


Ala Tyr Ile Lys Gln Gln Gly Ile His Phe Arg Glu Lys Pro Tyr Thr 
                405                 410                 415     


Cys Ser Glu Cys Gly Lys Asp Phe Arg Leu Asn Ser His Leu Ile Gln 
            420                 425                 430         


His Gln Arg Ile His Thr Gly Glu Lys Ala His Glu Cys Asn Glu Cys 
        435                 440                 445             


Gly Lys Ala Phe Ser Gln Thr Ser Cys Leu Ile Gln His His Lys Met 
    450                 455                 460                 


His Arg Lys Glu Lys Ser Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe 
465                 470                 475                 480 


Ser His Ser Ser Asp Leu Ile Leu Gln Gln Glu Val Leu Thr Arg Gln 
                485                 490                 495     


Lys Ala Phe Asp Cys Asp Val Trp Glu Lys Asn Ser Ser Gln Arg Ala 
            500                 505                 510         


His Leu Val Gln His Gln Ser Ile His Thr Lys Glu Asn Ser 
        515                 520                 525     


<210> 8320
<211> 64
<212> PRT
<213> Homo sapiens

<400> 8320
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


<210> 8321
<211> 246
<212> PRT
<213> Homo sapiens

<400> 8321
Met Ala Glu Gln Glu Gln Arg Lys Ile Pro Leu Val Pro Glu Asn Leu 
1               5                   10                  15      


Leu Lys Lys Arg Lys Ala Tyr Gln Ala Leu Lys Ala Thr Gln Ala Lys 
            20                  25                  30          


Gln Ala Leu Leu Ala Lys Lys Glu Gln Lys Lys Gly Lys Gly Leu Arg 
        35                  40                  45              


Phe Lys Arg Leu Glu Ser Phe Leu His Asp Ser Trp Arg Gln Lys Arg 
    50                  55                  60                  


Asp Lys Val Arg Leu Arg Arg Leu Glu Val Lys Pro His Ala Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Lys His Ser Leu Ala Phe Val Val Arg Ile Glu Arg Ile 
                85                  90                  95      


Asp Gly Val Ser Leu Leu Val Gln Arg Thr Ile Ala Arg Leu Arg Leu 
            100                 105                 110         


Lys Lys Ile Phe Ser Gly Val Phe Val Lys Val Thr Pro Gln Asn Leu 
        115                 120                 125             


Lys Met Leu Arg Ile Val Glu Pro Tyr Val Thr Trp Gly Phe Pro Asn 
    130                 135                 140                 


Leu Lys Ser Val Arg Glu Leu Ile Leu Lys Arg Gly Gln Ala Lys Val 
145                 150                 155                 160 


Lys Asn Lys Thr Ile Pro Leu Thr Asp Asn Thr Val Ile Glu Glu His 
                165                 170                 175     


Leu Gly Lys Phe Gly Val Ile Cys Leu Glu Asp Leu Ile His Glu Ile 
            180                 185                 190         


Ala Phe Pro Gly Lys His Phe Gln Glu Ile Ser Trp Phe Leu Cys Pro 
        195                 200                 205             


Phe His Leu Ser Val Ala Arg His Ala Thr Lys Asn Arg Val Gly Phe 
    210                 215                 220                 


Leu Lys Glu Met Gly Thr Pro Gly Tyr Arg Gly Glu Arg Ile Asn Gln 
225                 230                 235                 240 


Leu Ile Arg Gln Leu Asn 
                245     


<210> 8322
<211> 431
<212> PRT
<213> Homo sapiens

<400> 8322
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu Gln 
225                 230                 235                 240 


Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val 
                245                 250                 255     


His Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr 
            260                 265                 270         


Ser Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln 
        275                 280                 285             


Lys Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala 
    290                 295                 300                 


Ala Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro 
305                 310                 315                 320 


Ser Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu 
                325                 330                 335     


Glu Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln 
            340                 345                 350         


Gln Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln 
        355                 360                 365             


Gly Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln 
    370                 375                 380                 


Ala Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr 
385                 390                 395                 400 


Gly Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp 
                405                 410                 415     


Gly His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430     


<210> 8323
<211> 617
<212> PRT
<213> Homo sapiens

<400> 8323
Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
1               5                   10                  15      


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
            20                  25                  30          


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
        35                  40                  45              


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
    50                  55                  60                  


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
65                  70                  75                  80  


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
                85                  90                  95      


Lys Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu 
            100                 105                 110         


Val Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg 
        115                 120                 125             


Leu Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile 
    130                 135                 140                 


Ser Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val 
145                 150                 155                 160 


Cys Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys 
                165                 170                 175     


Ala Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn 
            180                 185                 190         


Phe Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu 
        195                 200                 205             


Glu Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu 
    210                 215                 220                 


Glu Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg 
225                 230                 235                 240 


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr 
                245                 250                 255     


Cys Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu 
            260                 265                 270         


Pro Tyr Thr Glu Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
        275                 280                 285             


Gly Asn Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe 
    290                 295                 300                 


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val 
305                 310                 315                 320 


Gln Ala Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val 
                325                 330                 335     


Thr Ala Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro 
            340                 345                 350         


Ala Val Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys 
        355                 360                 365             


Leu Ile Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys 
    370                 375                 380                 


Leu Glu Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu 
385                 390                 395                 400 


Leu His Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp 
                405                 410                 415     


Lys Met Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys 
            420                 425                 430         


Arg Val Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser 
        435                 440                 445             


Asn Lys Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala 
    450                 455                 460                 


Pro Asn Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Leu Ile 
465                 470                 475                 480 


Pro Gly Lys Ser Ala Ser Arg Phe Gly Arg Arg Gly Ser Ala Ile Gly 
                485                 490                 495     


Ile Gly Thr Val Glu Glu Val Val Val Arg Gly Ala Ala Gly Ser Gly 
            500                 505                 510         


Gly Cys Leu His Ala Leu Phe Ser Ala Arg Ser Gln Asp Gly Gly His 
        515                 520                 525             


Ile Gly Asp Val Ala Pro Leu Pro Pro Gly Gln Ala Pro Gly Arg Ala 
    530                 535                 540                 


Gly Trp Ser Gly Gly Ser Ser Asp Gly Thr Gln His Leu Leu Trp Gly 
545                 550                 555                 560 


Leu Val Pro Val Pro Glu Pro Val Pro Leu Thr Arg Gly Phe Trp Pro 
                565                 570                 575     


Cys Leu Gly Pro Trp Asp Pro Gly Pro Val Pro Ala Arg Ile Arg Tyr 
            580                 585                 590         


Pro Lys Ala Leu His Pro Ala Ala Arg Pro Pro Ile Ser Pro Val Cys 
        595                 600                 605             


Met Glu Arg His Pro Ser Pro Leu Pro 
    610                 615         


<210> 8324
<211> 407
<212> PRT
<213> Homo sapiens

<400> 8324
Met Gly Asn Thr Ser Phe Asn Glu Val Met Glu Ala Gln Leu Pro Ser 
1               5                   10                  15      


His Gly Gly Pro Lys Pro Ser Ala Glu Ser Asp Met Gly Thr Arg Arg 
            20                  25                  30          


Asp Tyr Ile Met Ala Lys Tyr Val Glu His Arg Phe Ala Arg Arg Cys 
        35                  40                  45              


Thr Pro Glu Pro Gln Arg Leu Trp Thr Ala Ile Cys Asn Arg Asp Leu 
    50                  55                  60                  


Leu Ser Val Leu Glu Ala Phe Ala Asn Gly Gln Asp Phe Gly Gln Pro 
65                  70                  75                  80  


Leu Pro Gly Pro Asp Ala Gln Ala Pro Glu Glu Leu Val Leu His Leu 
                85                  90                  95      


Ala Val Lys Val Ala Asn Gln Ala Ser Leu Pro Leu Val Asp Phe Ile 
            100                 105                 110         


Ile Gln Asn Gly Gly His Leu Asp Ala Lys Ala Ala Asp Gly Asn Thr 
        115                 120                 125             


Ala Leu His Tyr Ala Ala Leu Tyr Asn Gln Pro Asp Cys Leu Lys Leu 
    130                 135                 140                 


Leu Leu Lys Gly Arg Ala Leu Val Gly Thr Val Asn Glu Ala Gly Glu 
145                 150                 155                 160 


Thr Ala Leu Asp Ile Ala Arg Lys Lys His His Lys Glu Cys Glu Glu 
                165                 170                 175     


Leu Leu Glu Gln Ala Gln Ala Gly Thr Phe Ala Phe Pro Leu His Val 
            180                 185                 190         


Asp Tyr Ser Trp Val Ile Ser Thr Glu Pro Gly Ser Asp Ser Glu Glu 
        195                 200                 205             


Asp Glu Glu Glu Lys Arg Cys Leu Leu Lys Leu Pro Ala Gln Ala His 
    210                 215                 220                 


Trp Ala Ser Gly Arg Leu Asp Ile Ser Asn Lys Thr Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Ser Leu Gly Ala Ala Thr Pro Gln Gly Glu Ser Glu Asp Cys Pro 
                245                 250                 255     


Pro Pro Leu Pro Val Lys Asn Ser Ser Arg Thr Leu Val Gln Gly Cys 
            260                 265                 270         


Ala Arg His Ala Ser Gly Asp Arg Ser Glu Val Ser Ser Leu Ser Ser 
        275                 280                 285             


Glu Ala Pro Glu Thr Pro Glu Ser Leu Gly Ser Pro Ala Ser Ser Ser 
    290                 295                 300                 


Ser Leu Met Ser Pro Leu Glu Pro Gly Asp Pro Ser Gln Ala Pro Pro 
305                 310                 315                 320 


Asn Ser Glu Glu Gly Leu Arg Glu Pro Pro Gly Thr Ser Arg Pro Ser 
                325                 330                 335     


Leu Thr Ser Gly Thr Thr Pro Ser Glu Met Tyr Leu Pro Val Arg Phe 
            340                 345                 350         


Ser Ser Glu Ser Thr Arg Ser Tyr Arg Arg Gly Ala Arg Ser Pro Glu 
        355                 360                 365             


Asp Gly Pro Ser Ala Arg Gln Pro Leu Pro Arg Arg Asn Val Pro Val 
    370                 375                 380                 


Gly Ile Thr Glu Gly Asp Gly Ser Arg Thr Gly Ser Leu Pro Ala Ser 
385                 390                 395                 400 


Ser Val Gln Leu Leu Gln Asp 
                405         


<210> 8325
<211> 270
<212> PRT
<213> Homo sapiens

<400> 8325
Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Leu Gly 
    130                 135                 140                 


Gln Gly Val Leu Val Gln Val Ser Pro Ser Leu Val Lys Arg Gln Lys 
145                 150                 155                 160 


Thr His Phe His Asp Leu Pro Cys Gly Ala Ser Val Ile Leu Gly Asn 
                165                 170                 175     


Asn Gly Phe Ile Trp Ile Tyr Pro Thr Pro Glu His Lys Glu Glu Glu 
            180                 185                 190         


Ala Gly Gly Phe Ile Ala Asn Leu Glu Pro Val Ser Leu Ala Asp Arg 
        195                 200                 205             


Glu Val Ile Ser Arg Leu Arg Asn Cys Ile Ile Ser Leu Val Thr Gln 
    210                 215                 220                 


Arg Met Met Leu Tyr Asp Thr Ser Ile Leu Tyr Cys Tyr Glu Ala Ser 
225                 230                 235                 240 


Leu Pro His Gln Ile Lys Asp Ile Leu Lys Pro Glu Ile Met Glu Glu 
                245                 250                 255     


Ile Val Met Glu Thr Arg Gln Arg Leu Leu Glu Gln Glu Gly 
            260                 265                 270 


<210> 8326
<211> 98
<212> PRT
<213> Homo sapiens

<400> 8326
Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr 
                85                  90                  95      


Pro Ala 
        


<210> 8327
<211> 101
<212> PRT
<213> Homo sapiens

<400> 8327
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu 
1               5                   10                  15      


Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu 
            20                  25                  30          


Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val 
        35                  40                  45              


Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe 
    50                  55                  60                  


Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser 
65                  70                  75                  80  


Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro 
                85                  90                  95      


Lys Tyr Val Arg Gly 
            100     


<210> 8328
<211> 354
<212> PRT
<213> Homo sapiens

<400> 8328
Met Ala His Ser Pro Val Ala Val Gln Val Pro Gly Met Gln Asn Asn 
1               5                   10                  15      


Ile Ala Asp Pro Glu Glu Leu Phe Thr Lys Leu Glu Arg Ile Gly Lys 
            20                  25                  30          


Gly Ser Phe Gly Glu Val Phe Lys Gly Ile Asp Asn Arg Thr Gln Gln 
        35                  40                  45              


Val Val Ala Ile Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile 
    50                  55                  60                  


Glu Asp Ile Gln Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Ser 
65                  70                  75                  80  


Tyr Val Thr Lys Tyr Tyr Gly Ser Tyr Leu Lys Gly Ser Lys Leu Trp 
                85                  90                  95      


Ile Ile Met Glu Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Arg 
            100                 105                 110         


Ala Gly Pro Phe Asp Glu Phe Gln Ile Ala Thr Met Leu Lys Glu Ile 
        115                 120                 125             


Leu Lys Gly Leu Asp Tyr Leu His Ser Glu Lys Lys Ile His Arg Asp 
    130                 135                 140                 


Ile Lys Ala Ala Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu 
145                 150                 155                 160 


Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg 
                165                 170                 175     


Asn Thr Phe Val Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Gln 
            180                 185                 190         


Gln Ser Ala Tyr Asp Ser Lys Arg Pro Thr Ala Lys Glu Leu Leu Lys 
        195                 200                 205             


His Lys Phe Ile Val Lys Asn Ser Lys Lys Thr Ser Tyr Leu Thr Glu 
    210                 215                 220                 


Leu Ile Asp Arg Phe Lys Arg Trp Lys Ala Glu Gly His Ser Asp Asp 
225                 230                 235                 240 


Glu Ser Asp Ser Glu Gly Ser Asp Ser Glu Ser Thr Ser Arg Glu Asn 
                245                 250                 255     


Asn Thr His Pro Glu Trp Ser Phe Thr Thr Val Arg Lys Lys Pro Asp 
            260                 265                 270         


Pro Lys Lys Val Gln Asn Gly Ala Glu Gln Asp Leu Val Gln Thr Leu 
        275                 280                 285             


Ser Cys Leu Ser Met Ile Ile Thr Pro Ala Phe Ala Glu Leu Lys Gln 
    290                 295                 300                 


Gln Asp Glu Asn Asn Ala Ser Arg Asn Gln Ala Ile Glu Glu Leu Glu 
305                 310                 315                 320 


Lys Ser Ile Ala Val Ala Glu Ala Ala Cys Pro Gly Ile Thr Asp Lys 
                325                 330                 335     


Met Val Lys Lys Leu Ile Glu Lys Phe Gln Lys Cys Ser Ala Asp Glu 
            340                 345                 350         


Ser Pro 
        


<210> 8329
<211> 173
<212> PRT
<213> Homo sapiens

<400> 8329
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu 
1               5                   10                  15      


Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro 
            20                  25                  30          


Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr 
        35                  40                  45              


Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro 
65                  70                  75                  80  


Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala 
                85                  90                  95      


Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile 
            100                 105                 110         


Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe 
        115                 120                 125             


Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val 
    130                 135                 140                 


Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val 
145                 150                 155                 160 


Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp 
                165                 170             


<210> 8330
<211> 266
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8330
Xaa Pro Arg Ala Ala Ala Arg Val Arg Ala Ala Gly Glu Ala Leu Glu 
1               5                   10                  15      


Arg Arg Arg Arg Trp Leu Gly Arg Leu Ser Pro Ser Ala Pro Arg Pro 
            20                  25                  30          


Arg Arg Ala Arg Pro Ser Leu Arg Arg Ala Ser Ala Trp Val Arg Asp 
        35                  40                  45              


Arg Val Ala Gly Arg Pro Gly Ala Leu Pro Gly Phe Gln Ala Ser Gly 
    50                  55                  60                  


Val Ala Gly Glu Ala Gln Lys Ala Pro Gly His Pro Ala Ala Pro Ala 
65                  70                  75                  80  


Pro Ala Ala Ser Cys Leu Thr Glu Ala Asp Gly Arg Val Phe Leu His 
                85                  90                  95      


Ala Phe Arg Leu Ala Leu Ile Gln Leu Gln Ile Ser Ser Ile Lys Ser 
            100                 105                 110         


Asp Asn Val Thr Arg Ala Cys Ser Phe Ile Arg Glu Ala Ala Thr Gln 
        115                 120                 125             


Gly Ala Lys Ile Val Ser Leu Pro Glu Cys Phe Asn Ser Pro Tyr Gly 
    130                 135                 140                 


Ala Lys Tyr Phe Pro Glu Tyr Ala Glu Lys Ile Pro Gly Glu Ser Thr 
145                 150                 155                 160 


Gln Lys Leu Ser Glu Val Ala Lys Glu Cys Ser Ile Tyr Leu Ile Gly 
                165                 170                 175     


Gly Ser Ile Pro Glu Glu Asp Ala Gly Lys Leu Tyr Asn Thr Cys Ala 
            180                 185                 190         


Val Phe Gly Pro Asp Gly Thr Leu Leu Ala Lys Tyr Arg Lys Ile His 
        195                 200                 205             


Leu Phe Asp Ile Asp Val Pro Gly Lys Ile Thr Phe Gln Glu Ser Lys 
    210                 215                 220                 


Thr Leu Ser Pro Gly Asp Ser Phe Ser Thr Phe Asp Thr Pro Tyr Cys 
225                 230                 235                 240 


Arg Val Gly Leu Gly Ile Cys Tyr Asp Met Arg Phe Ala Glu Leu Ala 
                245                 250                 255     


Gln Ile Tyr Ala Gln Arg Gly Glu Ala Val 
            260                 265     


<210> 8331
<211> 71
<212> PRT
<213> Homo sapiens

<400> 8331
Met Asp Ser Leu Pro Asp Glu Phe Phe Val Arg His Pro Ala Val Glu 
1               5                   10                  15      


Asp Gln Arg Lys Glu Glu Thr Glu Asn Lys Leu Glu Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Asn Lys Gln Glu Asn Asp Ile Pro Thr Asp Leu Val Pro Val 
        35                  40                  45              


Asn Leu Leu Leu Glu Val Lys Lys Leu Leu Asn Ala Ile Asn Thr Leu 
    50                  55                  60                  


Pro Lys Gly Val Val Pro His 
65                  70      


<210> 8332
<211> 709
<212> PRT
<213> Homo sapiens

<400> 8332
Met Ser Val Glu Ser Glu Gln Leu Thr Gly Val Pro Leu Asp Asp Ser 
1               5                   10                  15      


Ala Ile Thr Pro Met Cys Glu Val Thr Gly Gly Arg Ser Tyr Ser Val 
            20                  25                  30          


Cys Ser Pro Arg Met Leu Asn Gln Cys Leu Glu Ser Leu Val Gln Lys 
        35                  40                  45              


Val Gln Ser Gly Val Val Ile Asn Phe Glu Lys Ala Gly Pro Asp Pro 
    50                  55                  60                  


Ser Pro Val Glu Asp Gly Gln Pro Asp Ile Ser Arg Pro Phe Gly Ser 
65                  70                  75                  80  


Gln Pro Trp His Ser Cys His Lys Leu Ile Tyr Val Arg Pro Asn Pro 
                85                  90                  95      


Lys Thr Gly Val Pro Ile Gly His Trp Pro Val Pro Glu Ser Phe Trp 
            100                 105                 110         


Pro Asp Gln Asn Ser Pro Thr Leu Pro Pro Arg Thr Ser His Pro Val 
        115                 120                 125             


Val Lys Phe Ser Cys Thr Asp Cys Glu Pro Met Val Ile Asp Lys Leu 
    130                 135                 140                 


Pro Phe Asp Lys Tyr Glu Leu Glu Pro Ser Pro Leu Thr Gln Phe Ile 
145                 150                 155                 160 


Leu Glu Arg Lys Ser Pro Gln Thr Cys Trp Gln Val Tyr Val Ser Asn 
                165                 170                 175     


Ser Ala Lys Tyr Ser Glu Leu Gly His Pro Phe Gly Tyr Leu Lys Ala 
            180                 185                 190         


Ser Thr Ala Leu Asn Cys Val Asn Leu Phe Val Met Pro Tyr Asn Tyr 
        195                 200                 205             


Pro Val Leu Leu Pro Leu Leu Asp Asp Leu Phe Lys Val His Lys Ala 
    210                 215                 220                 


Lys Pro Thr Leu Lys Trp Arg Gln Ser Phe Glu Ser Tyr Leu Lys Thr 
225                 230                 235                 240 


Met Pro Pro Tyr Tyr Leu Gly Pro Leu Lys Lys Ala Val Arg Met Met 
                245                 250                 255     


Gly Ala Pro Asn Leu Ile Ala Asp Ser Met Glu Tyr Gly Leu Ser Tyr 
            260                 265                 270         


Ser Val Ile Ser Tyr Leu Lys Lys Leu Ser Gln Gln Ala Lys Ile Glu 
        275                 280                 285             


Ser Asp Arg Val Ile Gly Ser Val Gly Lys Lys Val Val Gln Glu Thr 
    290                 295                 300                 


Gly Ile Lys Val Arg Ser Arg Ser His Gly Leu Ser Met Ala Tyr Arg 
305                 310                 315                 320 


Lys Asp Phe Gln Gln Leu Leu Gln Gly Ile Ser Glu Asp Val Pro His 
                325                 330                 335     


Arg Leu Leu Asp Leu Asn Met Lys Glu Tyr Thr Gly Phe Gln Val Ala 
            340                 345                 350         


Leu Leu Asn Lys Asp Leu Lys Pro Gln Thr Phe Arg Asn Ala Tyr Asp 
        355                 360                 365             


Ile Pro Arg Arg Asn Leu Leu Asp His Leu Thr Arg Met Arg Ser Asn 
    370                 375                 380                 


Leu Leu Lys Ser Thr Arg Arg Phe Leu Lys Gly Gln Asp Glu Asp Gln 
385                 390                 395                 400 


Val His Ser Val Pro Ile Ala Gln Met Gly Asn Tyr Gln Glu Tyr Leu 
                405                 410                 415     


Lys Gln Val Pro Ser Pro Leu Arg Glu Leu Asp Pro Asp Gln Pro Arg 
            420                 425                 430         


Arg Leu His Thr Phe Gly Asn Pro Phe Lys Leu Asp Lys Lys Gly Met 
        435                 440                 445             


Met Ile Asp Glu Ala Asp Glu Phe Val Ala Gly Pro Gln Asn Lys His 
    450                 455                 460                 


Lys Arg Pro Gly Glu Pro Asn Met Gln Gly Ile Pro Lys Arg Arg Arg 
465                 470                 475                 480 


Cys Met Ser Pro Leu Leu Arg Gly Arg Gln Gln Asn Pro Val Val Asn 
                485                 490                 495     


Asn His Ile Gly Gly Lys Gly Pro Pro Ala Pro Thr Thr Gln Ala Gln 
            500                 505                 510         


Pro Asp Leu Ile Lys Pro Leu Pro Leu His Lys Ile Ser Glu Thr Thr 
        515                 520                 525             


Asn Asp Ser Ile Ile His Asp Val Val Glu Asn His Val Ala Asp Gln 
    530                 535                 540                 


Leu Ser Ser Asp Ile Thr Pro Asn Ala Met Asp Thr Glu Phe Ser Ala 
545                 550                 555                 560 


Ser Ser Pro Ala Ser Leu Leu Glu Arg Pro Thr Asn His Met Glu Ala 
                565                 570                 575     


Leu Gly His Asp His Leu Gly Thr Asn Asp Leu Thr Val Gly Gly Phe 
            580                 585                 590         


Leu Glu Asn His Glu Glu Pro Arg Asp Lys Glu Gln Cys Ala Glu Glu 
        595                 600                 605             


Asn Ile Pro Ala Ser Ser Leu Asn Lys Gly Lys Lys Leu Met His Cys 
    610                 615                 620                 


Arg Ser His Glu Glu Val Asn Thr Glu Leu Lys Ala Gln Ile Met Lys 
625                 630                 635                 640 


Glu Ile Arg Lys Pro Gly Arg Lys Tyr Glu Arg Ile Phe Thr Leu Leu 
                645                 650                 655     


Lys His Val Gln Gly Ser Leu Gln Thr Arg Leu Ile Phe Leu Gln Asn 
            660                 665                 670         


Val Ile Lys Glu Ala Ser Arg Phe Lys Lys Arg Met Leu Ile Glu Gln 
        675                 680                 685             


Leu Glu Asn Phe Leu Asp Glu Ile His Arg Arg Ala Asn Gln Ile Asn 
    690                 695                 700                 


His Ile Asn Ser Asn 
705                 


<210> 8333
<211> 128
<212> PRT
<213> Homo sapiens

<400> 8333
Met Ala Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr 
1               5                   10                  15      


Ser Ile Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu 
            20                  25                  30          


Gly Asp Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr 
        35                  40                  45              


Lys Ala Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg 
    50                  55                  60                  


Lys Phe Pro Lys Leu Thr Ile Ile Gly Glu Glu Asp Leu Pro Ser Glu 
65                  70                  75                  80  


Glu Val Asp Gln Glu Leu Ile Glu Asp Ser Gln Trp Glu Glu Ile Leu 
                85                  90                  95      


Lys Gln Pro Cys Pro Ser Gln Tyr Ser Ala Ile Lys Glu Glu Asp Leu 
            100                 105                 110         


Val Val Trp Val Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly 
        115                 120                 125             


<210> 8334
<211> 78
<212> PRT
<213> Homo sapiens

<400> 8334
Met Arg Phe Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg 
1               5                   10                  15      


Lys Pro Val Glu Gly Tyr Asp Ile Ser Phe Leu Ile Thr Asn Phe His 
            20                  25                  30          


Thr Glu Gln Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe 
        35                  40                  45              


Met Glu Glu Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn 
    50                  55                  60                  


Ala Arg Ala Arg Ile Val Ala Glu Glu Phe Leu Lys Asn Phe 
65                  70                  75              


<210> 8335
<211> 56
<212> PRT
<213> Homo sapiens

<400> 8335
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr 
    50                  55      


<210> 8336
<211> 118
<212> PRT
<213> Homo sapiens

<400> 8336
Met Lys Ile Phe Val Gly Asn Val Asp Gly Ala Asp Thr Thr Pro Glu 
1               5                   10                  15      


Glu Leu Ala Ala Leu Phe Ala Pro Tyr Gly Thr Val Met Ser Cys Ala 
            20                  25                  30          


Val Met Lys Gln Phe Ala Phe Val His Met Arg Glu Asn Ala Gly Ala 
        35                  40                  45              


Leu Arg Ala Ile Glu Ala Leu His Gly His Glu Leu Arg Pro Gly Arg 
    50                  55                  60                  


Ala Leu Val Val Glu Met Ser Arg Pro Arg Pro Leu Asn Thr Trp Lys 
65                  70                  75                  80  


Ile Phe Val Gly Asn Val Ser Ala Ala Cys Thr Ser Gln Glu Leu Arg 
                85                  90                  95      


Ser Leu Phe Glu Arg Arg Gly Arg Val Ile Glu Cys Asp Val Val Lys 
            100                 105                 110         


Gly Gly Met Cys Val Gly 
        115             


<210> 8337
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8337
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Val Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe 
        115                 120                 125             


Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys 
    130                 135                 140                 


Ala 
145 


<210> 8338
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8338
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe 
        115                 120                 125             


Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys 
    130                 135                 140                 


Ala 
145 


<210> 8339
<211> 147
<212> PRT
<213> Homo sapiens

<400> 8339
Met Trp Lys Phe Pro Gly Gly Leu Ser Glu Pro Glu Glu Asp Ile Gly 
1               5                   10                  15      


Asp Thr Ala Val Arg Glu Val Phe Glu Glu Thr Gly Ile Lys Ser Glu 
            20                  25                  30          


Phe Arg Ser Val Leu Ser Ile Arg Gln Gln His Thr Asn Pro Gly Ala 
        35                  40                  45              


Phe Gly Lys Ser Asp Met Tyr Ile Ile Cys Arg Leu Lys Pro Tyr Ser 
    50                  55                  60                  


Phe Thr Ile Asn Phe Cys Gln Glu Glu Cys Leu Arg Cys Glu Trp Met 
65                  70                  75                  80  


Asp Leu Asn Asp Leu Ala Lys Thr Glu Asn Thr Thr Pro Ile Thr Ser 
                85                  90                  95      


Arg Val Ala Arg Leu Leu Leu Tyr Gly Tyr Arg Glu Gly Phe Asp Lys 
            100                 105                 110         


Ile Asp Leu Thr Val Glu Glu Leu Pro Ala Val Tyr Thr Gly Leu Phe 
        115                 120                 125             


Tyr Lys Leu Tyr His Lys Glu Leu Pro Glu Asn Tyr Lys Thr Met Lys 
    130                 135                 140                 


Gly Ile Asp 
145         


<210> 8340
<211> 99
<212> PRT
<213> Homo sapiens

<400> 8340
Met Asp Glu Ser Ala Leu Leu Asp Leu Leu Glu Cys Pro Val Cys Leu 
1               5                   10                  15      


Glu Arg Leu Asp Ala Ser Ala Lys Val Leu Pro Cys Gln His Thr Phe 
            20                  25                  30          


Cys Lys Arg Cys Leu Leu Gly Ile Val Gly Ser Arg Asn Glu Leu Arg 
        35                  40                  45              


Cys Pro Glu Cys Arg Thr Leu Val Gly Ser Gly Val Glu Glu Leu Pro 
    50                  55                  60                  


Ser Asn Ile Leu Leu Val Arg Leu Leu Asp Gly Ile Lys Gln Arg Pro 
65                  70                  75                  80  


Trp Lys Pro Gly Pro Gly Gly Gly Ser Gly Thr Asn Cys Thr Asn Ala 
                85                  90                  95      


Leu Arg Ser 
            


<210> 8341
<211> 1224
<212> PRT
<213> Homo sapiens

<400> 8341
Met Ala Leu Arg Pro Gly Ala Gly Ser Gly Gly Gly Gly Ala Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ser Ala Gly Gly Gly Gly Phe Met Phe Pro Val Ala 
            20                  25                  30          


Gly Gly Ile Arg Pro Pro Gln Ala Gly Leu Met Pro Met Gln Gln Gln 
        35                  40                  45              


Gly Phe Pro Met Val Ser Val Met Gln Pro Asn Met Gln Gly Ile Met 
    50                  55                  60                  


Gly Met Asn Tyr Ser Ser Gln Met Ser Gln Gly Pro Ile Ala Met Gln 
65                  70                  75                  80  


Ala Gly Ile Pro Met Gly Pro Met Pro Ala Ala Gly Met Pro Tyr Leu 
                85                  90                  95      


Gly Gln Ala Pro Phe Leu Gly Met Arg Pro Pro Gly Pro Gln Tyr Thr 
            100                 105                 110         


Pro Asp Met Gln Lys Gln Phe Ala Glu Glu Gln Gln Lys Arg Phe Glu 
        115                 120                 125             


Gln Gln Gln Lys Leu Leu Glu Glu Glu Arg Lys Arg Arg Gln Phe Glu 
    130                 135                 140                 


Glu Gln Lys Gln Lys Leu Arg Leu Leu Ser Ser Val Lys Pro Lys Thr 
145                 150                 155                 160 


Gly Glu Lys Ser Arg Asp Asp Ala Leu Glu Ala Ile Lys Gly Asn Leu 
                165                 170                 175     


Asp Gly Phe Ser Arg Asp Ala Lys Met His Pro Thr Pro Ala Ser His 
            180                 185                 190         


Pro Lys Lys Pro Gly Val Gly Val Phe Pro Ser Gln Asp Pro Ala Gln 
        195                 200                 205             


Pro Arg Met Pro Pro Trp Ile Tyr Asn Glu Ser Leu Val Pro Asp Ala 
    210                 215                 220                 


Tyr Lys Lys Ile Leu Glu Thr Thr Met Thr Pro Thr Gly Ile Asp Thr 
225                 230                 235                 240 


Ala Lys Leu Tyr Pro Ile Leu Met Ser Ser Gly Leu Pro Arg Glu Thr 
                245                 250                 255     


Leu Gly Gln Ile Trp Ala Leu Ala Asn Arg Thr Thr Pro Gly Lys Leu 
            260                 265                 270         


Thr Lys Glu Glu Leu Tyr Thr Val Leu Ala Met Ile Ala Val Thr Gln 
        275                 280                 285             


Arg Gly Val Pro Ala Met Ser Pro Asp Ala Leu Asn Gln Phe Pro Ala 
    290                 295                 300                 


Ala Pro Ile Pro Thr Leu Ser Gly Phe Ser Met Thr Leu Pro Thr Pro 
305                 310                 315                 320 


Val Ser Gln Pro Thr Val Ile Pro Ser Gly Pro Ala Gly Ser Met Pro 
                325                 330                 335     


Leu Ser Leu Gly Gln Pro Val Met Gly Ile Asn Leu Val Gly Pro Val 
            340                 345                 350         


Gly Gly Ala Ala Ala Gln Ala Ser Ser Gly Phe Ile Pro Thr Tyr Pro 
        355                 360                 365             


Ala Asn Gln Val Val Lys Pro Glu Glu Asp Asp Phe Gln Asp Phe Gln 
    370                 375                 380                 


Asp Ala Ser Lys Ser Gly Ser Leu Asp Asp Ser Phe Ser Asp Phe Gln 
385                 390                 395                 400 


Glu Leu Pro Ala Ser Ser Lys Thr Ser Asn Ser Gln His Gly Asn Ser 
                405                 410                 415     


Ala Pro Ser Leu Leu Met Pro Leu Pro Gly Thr Lys Ala Leu Pro Ser 
            420                 425                 430         


Met Asp Lys Tyr Ala Val Phe Lys Gly Ile Ala Ala Asp Lys Ser Ser 
        435                 440                 445             


Glu Asn Thr Val Pro Pro Gly Asp Pro Gly Asp Lys Tyr Ser Ala Phe 
    450                 455                 460                 


Arg Glu Leu Glu Gln Thr Ala Glu Asn Lys Pro Leu Gly Glu Ser Phe 
465                 470                 475                 480 


Ala Glu Phe Arg Ser Ala Gly Thr Asp Asp Gly Phe Thr Asp Phe Lys 
                485                 490                 495     


Thr Ala Asp Ser Val Ser Pro Leu Glu Pro Pro Thr Lys Asp Lys Thr 
            500                 505                 510         


Phe Pro Pro Ser Phe Pro Ser Gly Thr Ile Gln Gln Lys Gln Gln Thr 
        515                 520                 525             


Gln Val Lys Asn Pro Leu Asn Leu Ala Asp Leu Asp Met Phe Ser Ser 
    530                 535                 540                 


Val Asn Cys Ser Ser Glu Lys Pro Leu Ser Phe Ser Ala Val Phe Ser 
545                 550                 555                 560 


Thr Ser Lys Ser Val Ser Thr Pro Gln Ser Thr Gly Ser Ala Ala Thr 
                565                 570                 575     


Met Thr Ala Leu Ala Ala Thr Lys Thr Ser Ser Leu Ala Asp Asp Phe 
            580                 585                 590         


Gly Glu Phe Ser Leu Phe Gly Glu Tyr Ser Gly Leu Ala Pro Val Gly 
        595                 600                 605             


Glu Gln Asp Asp Phe Ala Asp Phe Met Ala Phe Ser Asn Ser Ser Ile 
    610                 615                 620                 


Ser Ser Glu Gln Lys Pro Asp Asp Lys Tyr Asp Ala Leu Lys Glu Glu 
625                 630                 635                 640 


Ala Ser Pro Val Pro Leu Thr Ser Asn Val Gly Ser Thr Val Lys Gly 
                645                 650                 655     


Gly Gln Asn Ser Thr Ala Ala Ser Thr Lys Tyr Asp Val Phe Arg Gln 
            660                 665                 670         


Leu Ser Leu Glu Gly Ser Gly Leu Gly Val Glu Asp Leu Lys Asp Asn 
        675                 680                 685             


Thr Pro Ser Gly Lys Ser Asp Asp Asp Phe Ala Asp Phe His Ser Ser 
    690                 695                 700                 


Lys Phe Ser Ser Ile Asn Ser Asp Lys Ser Leu Gly Glu Lys Ala Val 
705                 710                 715                 720 


Ala Phe Arg His Thr Lys Glu Asp Ser Ala Ser Val Lys Ser Leu Asp 
                725                 730                 735     


Leu Pro Ser Ile Gly Gly Ser Ser Val Gly Lys Glu Asp Ser Glu Asp 
            740                 745                 750         


Ala Leu Ser Val Gln Phe Asp Met Lys Leu Ala Asp Val Gly Gly Asp 
        755                 760                 765             


Leu Lys His Val Met Ser Asp Ser Ser Leu Asp Leu Pro Thr Val Ser 
    770                 775                 780                 


Gly Gln His Pro Pro Ala Ala Asp Ile Glu Asp Leu Lys Tyr Ala Ala 
785                 790                 795                 800 


Phe Gly Ser Tyr Ser Ser Asn Phe Ala Val Ser Thr Leu Thr Ser Tyr 
                805                 810                 815     


Asp Trp Ser Asp Arg Asp Asp Ala Thr Gln Gly Arg Lys Leu Ser Pro 
            820                 825                 830         


Phe Val Leu Ser Ala Gly Ser Gly Ser Pro Ser Ala Thr Ser Ile Leu 
        835                 840                 845             


Gln Lys Lys Glu Thr Ser Phe Gly Ser Ser Glu Asn Ile Thr Met Thr 
    850                 855                 860                 


Ser Leu Ser Lys Val Thr Thr Phe Val Ser Glu Asp Ala Leu Pro Glu 
865                 870                 875                 880 


Thr Thr Phe Pro Ala Leu Ala Ser Phe Lys Asp Thr Ile Pro Gln Thr 
                885                 890                 895     


Ser Glu Gln Lys Glu Tyr Glu Asn Arg Asp Tyr Lys Asp Phe Thr Lys 
            900                 905                 910         


Gln Asp Leu Pro Thr Ala Glu Arg Ser Gln Glu Ala Thr Cys Pro Ser 
        915                 920                 925             


Pro Ala Ser Ser Gly Ala Ser Gln Glu Thr Pro Asn Glu Cys Ser Asp 
    930                 935                 940                 


Asp Phe Gly Glu Phe Gln Ser Glu Lys Pro Lys Ile Ser Lys Phe Asp 
945                 950                 955                 960 


Phe Leu Val Ala Thr Ser Gln Ser Lys Met Lys Ser Ser Glu Glu Met 
                965                 970                 975     


Ile Lys Ser Glu Leu Ala Thr Phe Asp Leu Ser Val Gln Gly Ser His 
            980                 985                 990         


Lys Arg Ser Leu Ser Leu Gly Asp  Lys Glu Ile Ser Arg  Ser Ser Pro 
        995                 1000                 1005             


Ser Pro  Ala Leu Glu Gln Pro  Phe Arg Asp Arg Ser  Asn Thr Leu 
    1010                 1015                 1020             


Asn Glu  Lys Pro Ala Leu Pro  Val Ile Arg Asp Lys  Tyr Lys Asp 
    1025                 1030                 1035             


Leu Thr  Gly Glu Val Glu Glu  Asn Glu Arg Tyr Ala  Tyr Glu Trp 
    1040                 1045                 1050             


Gln Arg  Cys Leu Gly Ser Ala  Leu Asn Val Ile Lys  Lys Ala Asn 
    1055                 1060                 1065             


Asp Thr  Leu Asn Gly Ile Ser  Ser Ser Ser Val Cys  Thr Glu Val 
    1070                 1075                 1080             


Ile Gln  Ser Ala Gln Gly Met  Glu Tyr Leu Leu Gly  Val Val Glu 
    1085                 1090                 1095             


Val Tyr  Arg Val Thr Lys Arg  Val Glu Leu Gly Ile  Lys Ala Thr 
    1100                 1105                 1110             


Ala Val  Cys Ser Glu Lys Leu  Gln Gln Leu Leu Lys  Asp Ile Asp 
    1115                 1120                 1125             


Lys Val  Trp Asn Asn Leu Ile  Gly Phe Met Ser Leu  Ala Thr Leu 
    1130                 1135                 1140             


Thr Pro  Asp Glu Asn Ser Leu  Asp Phe Ser Ser Cys  Met Leu Arg 
    1145                 1150                 1155             


Pro Gly  Ile Lys Asn Ala Gln  Glu Leu Ala Cys Gly  Val Cys Leu 
    1160                 1165                 1170             


Leu Asn  Val Asp Ser Arg Ser  Arg Ala Phe Asn Ser  Glu Thr Asp 
    1175                 1180                 1185             


Ser Phe  Lys Leu Ala Tyr Gly  Gly His Gln Tyr His  Ala Ser Cys 
    1190                 1195                 1200             


Ala Asn  Phe Trp Ile Asn Cys  Val Glu Pro Lys Pro  Pro Gly Leu 
    1205                 1210                 1215             


Val Leu  Pro Asp Leu Leu 
    1220                 


<210> 8342
<211> 117
<212> PRT
<213> Homo sapiens

<400> 8342
Met Val Gln Arg Leu Thr Tyr Arg Arg Arg Leu Ser Tyr Asn Thr Ala 
1               5                   10                  15      


Ser Asn Lys Thr Arg Leu Ser Arg Thr Pro Gly Asn Arg Ile Val Tyr 
            20                  25                  30          


Leu Tyr Thr Lys Lys Val Gly Lys Ala Pro Lys Ser Ala Cys Gly Val 
        35                  40                  45              


Cys Pro Gly Arg Leu Arg Gly Val Arg Ala Val Arg Pro Lys Val Leu 
    50                  55                  60                  


Met Arg Leu Ser Lys Thr Lys Lys His Val Ser Arg Ala Tyr Gly Gly 
65                  70                  75                  80  


Ser Met Cys Ala Lys Cys Val Arg Asp Arg Ile Lys Arg Ala Phe Leu 
                85                  90                  95      


Ile Glu Glu Gln Lys Ile Val Val Lys Val Leu Lys Ala Gln Ala Gln 
            100                 105                 110         


Ser Gln Lys Ala Lys 
        115         


<210> 8343
<211> 206
<212> PRT
<213> Homo sapiens

<400> 8343
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu 
                165                 170                 175     


Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr 
            180                 185                 190         


Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
        195                 200                 205     


<210> 8344
<211> 193
<212> PRT
<213> Homo sapiens

<400> 8344
Met Glu Glu Thr Ile Lys Asp Pro Pro Thr Ser Ala Val Leu Leu Asp 
1               5                   10                  15      


His Cys His Phe Ser Gln Val Ile Phe Asn Ser Val Glu Lys Phe Tyr 
            20                  25                  30          


Ile Pro Gly Gly Asp Val Thr Cys His Tyr Thr Phe Thr Gln His Phe 
        35                  40                  45              


Ile Pro Arg Arg Lys Asp Trp Ile Gly Ile Phe Arg Val Gly Trp Lys 
    50                  55                  60                  


Thr Thr Arg Glu Tyr Tyr Thr Phe Met Trp Val Thr Leu Pro Ile Asp 
65                  70                  75                  80  


Leu Asn Asn Lys Ser Ala Lys Gln Gln Glu Val Gln Phe Lys Ala Tyr 
                85                  90                  95      


Tyr Leu Pro Lys Asp Asp Glu Tyr Tyr Gln Phe Cys Tyr Val Asp Glu 
            100                 105                 110         


Asp Gly Val Val Arg Gly Ala Ser Ile Pro Phe Gln Phe Arg Pro Glu 
        115                 120                 125             


Asn Glu Glu Asp Ile Leu Val Val Thr Thr Gln Gly Glu Val Glu Glu 
    130                 135                 140                 


Ile Glu Gln His Asn Lys Glu Leu Cys Lys Glu Asn Gln Glu Leu Lys 
145                 150                 155                 160 


Asp Ser Cys Ile Ser Leu Gln Lys Gln Asn Ser Asp Met Gln Ala Glu 
                165                 170                 175     


Leu Gln Lys Lys Gln Glu Glu Leu Glu Thr Leu Gln Ser Ile Asn Lys 
            180                 185                 190         


Lys 
    


<210> 8345
<211> 51
<212> PRT
<213> Homo sapiens

<400> 8345
Met Asp Phe Phe Ser Ser His Leu Leu Ala Asp Ser Ser Ser Pro Ala 
1               5                   10                  15      


Thr Asn Ser Ser His Thr Asp Ala His Glu Ile Leu Val Ser Asp Phe 
            20                  25                  30          


Leu Val Ser Asp Glu Asn Leu Gln Lys Met Glu Asn Val Leu Asp Leu 
        35                  40                  45              


Trp Ser Ser 
    50      


<210> 8346
<211> 170
<212> PRT
<213> Homo sapiens

<400> 8346
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Phe Gln Phe Val Ser Ser Ser Leu Pro Asp Ile Cys Tyr 
        35                  40                  45              


Arg Cys Gly Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln Glu 
    50                  55                  60                  


Asp Ala Cys Tyr Asn Cys Gly Arg Gly Gly His Ile Ala Lys Asp Cys 
65                  70                  75                  80  


Lys Glu Pro Lys Arg Glu Arg Glu Gln Cys Cys Tyr Asn Cys Gly Lys 
                85                  90                  95      


Pro Gly His Leu Ala Arg Asp Cys Asp His Ala Asp Glu Gln Lys Cys 
            100                 105                 110         


Tyr Ser Cys Gly Glu Phe Gly His Ile Gln Lys Asp Cys Thr Lys Val 
        115                 120                 125             


Lys Cys Tyr Arg Cys Gly Glu Thr Gly His Val Ala Ile Asn Cys Ser 
    130                 135                 140                 


Lys Thr Ser Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly His Leu 
145                 150                 155                 160 


Ala Arg Glu Cys Thr Ile Glu Ala Thr Ala 
                165                 170 


<210> 8347
<211> 132
<212> PRT
<213> Homo sapiens

<400> 8347
Met Asn Gln Glu Asp Leu Asp Pro Asp Ser Thr Thr Asp Val Gly Asp 
1               5                   10                  15      


Val Thr Asn Thr Glu Glu Glu Leu Ile Arg Glu Cys Glu Glu Met Trp 
            20                  25                  30          


Lys Asp Met Glu Glu Cys Gln Asn Lys Leu Ser Leu Ile Gly Thr Glu 
        35                  40                  45              


Thr Leu Thr Asp Ser Asn Ala Gln Leu Ser Leu Leu Ile Met Gln Val 
    50                  55                  60                  


Lys Cys Leu Thr Ala Glu Leu Ser Gln Trp Gln Lys Lys Thr Pro Glu 
65                  70                  75                  80  


Thr Ile Pro Leu Thr Glu Asp Val Leu Ile Thr Leu Gly Lys Glu Glu 
                85                  90                  95      


Phe Gln Lys Leu Arg Gln Asp Leu Glu Met Val Leu Ser Thr Lys Glu 
            100                 105                 110         


Ser Lys Asn Glu Lys Leu Lys Glu Asp Leu Glu Arg Glu Gln Arg Trp 
        115                 120                 125             


Leu Asp Glu Gln 
    130         


<210> 8348
<211> 364
<212> PRT
<213> Homo sapiens

<400> 8348
Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Lys Arg Met His Val Gln 
    130                 135                 140                 


Leu Ser Thr Ser Arg Leu Arg Thr Ala Pro Gly Met Gly Asp Gln Ser 
145                 150                 155                 160 


Gly Cys Tyr Arg Cys Gly Lys Glu Gly His Trp Ser Lys Glu Cys Pro 
                165                 170                 175     


Ile Asp Arg Ser Gly Arg Val Ala Asp Leu Thr Glu Gln Tyr Asn Glu 
            180                 185                 190         


Gln Tyr Gly Ala Val Arg Thr Pro Tyr Thr Met Ser Tyr Gly Asp Ser 
        195                 200                 205             


Leu Tyr Tyr Asn Asn Ala Tyr Gly Ala Leu Asp Ala Tyr Tyr Lys Arg 
    210                 215                 220                 


Cys Arg Ala Ala Arg Ser Tyr Glu Ala Val Ala Ala Ala Ala Ala Ser 
225                 230                 235                 240 


Val Tyr Asn Tyr Ala Glu Gln Thr Leu Ser Gln Leu Pro Gln Val Gln 
                245                 250                 255     


Asn Thr Ala Met Ala Ser His Leu Thr Ser Thr Ser Leu Asp Pro Tyr 
            260                 265                 270         


Asp Arg His Leu Leu Pro Thr Ser Gly Ala Ala Ala Thr Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Val Thr Ala Ala Ser Thr Ser Tyr Tyr 
    290                 295                 300                 


Gly Arg Asp Arg Ser Pro Leu Arg Arg Ala Thr Ala Pro Val Pro Thr 
305                 310                 315                 320 


Val Gly Glu Gly Tyr Gly Tyr Gly His Glu Ser Glu Leu Ser Gln Ala 
                325                 330                 335     


Ser Ala Ala Ala Arg Asn Ser Leu Tyr Asp Met Ala Arg Tyr Glu Arg 
            340                 345                 350         


Glu Gln Tyr Ala Asp Arg Ala Arg Tyr Ser Ala Phe 
        355                 360                 


<210> 8349
<211> 139
<212> PRT
<213> Homo sapiens

<400> 8349
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


Leu Asn Cys Val Met Lys Lys His Lys Glu Leu Ser Ser Leu Gln Lys 
        115                 120                 125             


Ile Pro Ser Gln Gln Arg Lys Lys Ile Ser Ser 
    130                 135                 


<210> 8350
<211> 149
<212> PRT
<213> Homo sapiens

<400> 8350
Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      


Leu Lys Ser Glu Glu Val Arg Phe Ile Thr Lys Ile Trp His Pro Asn 
            20                  25                  30          


Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu Lys Asp Gln 
        35                  40                  45              


Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser Leu Gln Ala 
    50                  55                  60                  


Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala Val Val Ala 
65                  70                  75                  80  


Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr Ala Arg Leu 
                85                  90                  95      


Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro Glu Tyr Thr 
            100                 105                 110         


Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg Asn Ala Val 
        115                 120                 125             


Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr Ala Thr Glu 
    130                 135                 140                 


Leu Leu Leu Ser Asn 
145                 


<210> 8351
<211> 198
<212> PRT
<213> Homo sapiens

<400> 8351
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
    130                 135                 140                 


Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
145                 150                 155                 160 


Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                165                 170                 175     


Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
            180                 185                 190         


Ser His Glu Pro Glu Pro 
        195             


<210> 8352
<211> 49
<212> PRT
<213> Homo sapiens

<400> 8352
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg 
    


<210> 8353
<211> 421
<212> PRT
<213> Homo sapiens

<400> 8353
Met Met Glu Asp Asn Lys Gln Leu Ala Leu Arg Ile Asp Gly Ala Val 
1               5                   10                  15      


Gln Ser Ala Ser Gln Glu Val Thr Asn Leu Arg Ala Glu Leu Thr Ala 
            20                  25                  30          


Thr Asn Arg Arg Leu Ala Glu Leu Ser Gly Gly Gly Gly Pro Gly Pro 
        35                  40                  45              


Gly Pro Gly Ala Ala Ala Ser Ala Ser Ala Ala Gly Asp Ser Ala Ala 
    50                  55                  60                  


Thr Asn Met Glu Asn Pro Gln Leu Gly Ala Gln Val Leu Leu Arg Glu 
65                  70                  75                  80  


Glu Val Ser Arg Leu Gln Glu Glu Val His Leu Leu Arg Gln Met Lys 
                85                  90                  95      


Glu Met Leu Ala Lys Asp Leu Glu Glu Ser Gln Gly Gly Lys Ser Ser 
            100                 105                 110         


Glu Val Leu Ser Ala Thr Glu Leu Arg Val Gln Leu Ala Gln Lys Glu 
        115                 120                 125             


Gln Glu Leu Ala Arg Ala Lys Glu Ala Leu Gln Ala Met Lys Ala Asp 
    130                 135                 140                 


Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln Met Gln 
145                 150                 155                 160 


Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg Asp Phe 
                165                 170                 175     


Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala Val Lys 
            180                 185                 190         


Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp Glu Leu 
        195                 200                 205             


Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu Arg Ser 
    210                 215                 220                 


Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val Pro Lys 
                245                 250                 255     


Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu Asn Gly Asn Gln 
            260                 265                 270         


Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala Ala Ile Arg Gln 
        275                 280                 285             


Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His Pro Ala Asp Arg 
    290                 295                 300                 


Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln Pro Ser Val Ile 
305                 310                 315                 320 


Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser Thr Pro Ser Asp 
                325                 330                 335     


Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys Asn Gly Asp Ser 
            340                 345                 350         


Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro Ile Val Gln Ser Leu 
        355                 360                 365             


Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys Glu Lys Met Gly 
    370                 375                 380                 


Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly Lys Gln Arg Lys Ser 
385                 390                 395                 400 


Leu Asp Pro Gly Leu Phe Asp Gly Thr Ala Pro Asp Tyr Tyr Ile Glu 
                405                 410                 415     


Glu Asp Ala Asp Trp 
            420     


<210> 8354
<211> 390
<212> PRT
<213> Homo sapiens

<400> 8354
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


Leu Asn Cys Val Met Lys Lys His Lys Glu Leu Ser Ser Leu Gln Lys 
        115                 120                 125             


Ile Pro Ser Gln Gln Arg Lys Lys Ile Ser Ser Gly Lys Ser Glu Pro 
    130                 135                 140                 


Pro Leu Gly Asn Glu Lys Ile Ser Ala Glu Ala Val Gly Val Asp Ile 
145                 150                 155                 160 


Ser Gly Arg Phe Met Thr Ser Gly Lys Lys Lys Ala Val Val Ile Arg 
                165                 170                 175     


His Leu Tyr Asn Glu Asp Asn Val Asp Ile Ser Glu Asp Thr Leu Ser 
            180                 185                 190         


Pro Ile Thr Asp Val Asn Glu Ala Val Asp Val Ser Asp Leu Asn Ala 
        195                 200                 205             


Thr Glu Ile Lys Met Pro Glu Val Lys Val Pro Glu Ile Lys Ala Glu 
    210                 215                 220                 


Gln Gln Asp Val Asn Val Asn Pro Glu Ile Thr Ala Leu Gln Thr Met 
225                 230                 235                 240 


Leu Ala Glu Cys Gln Glu Asn Leu Lys Lys Leu Thr Ser Ile Glu Lys 
                245                 250                 255     


Arg Leu Asp Cys Leu Glu Gln Lys Met Lys Gly Lys Val Met Val Asp 
            260                 265                 270         


Glu Asn Thr Trp Thr Asn Leu Leu Ser Arg Val Thr Leu Leu Glu Thr 
        275                 280                 285             


Glu Met Leu Leu Ser Lys Lys Asn Asp Glu Phe Ile Glu Phe Asn Glu 
    290                 295                 300                 


Val Ser Glu Asp Tyr Ala Ser Cys Ser Asp Met Asp Leu Leu Asn Pro 
305                 310                 315                 320 


His Arg Lys Ser Glu Val Glu Arg Pro Ala Ser Ile Pro Leu Ser Ser 
                325                 330                 335     


Gly Tyr Ser Thr Ala Ser Ser Asp Ser Thr Pro Arg Ala Ser Thr Val 
            340                 345                 350         


Asn Tyr Cys Gly Leu Asn Glu Ile Ser Glu Glu Thr Thr Ile Gln Lys 
        355                 360                 365             


Met Glu Arg Met Lys Lys Met Phe Glu Glu Thr Ala Glu Leu Leu Lys 
    370                 375                 380                 


Cys Pro Asn His Tyr Leu 
385                 390 


<210> 8355
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8355
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val 
    


<210> 8356
<211> 162
<212> PRT
<213> Homo sapiens

<400> 8356
Met Asp Phe Phe Ser Ser His Leu Leu Ala Asp Ser Ser Ser Pro Ala 
1               5                   10                  15      


Thr Asn Ser Ser His Thr Asp Ala His Glu Ile Leu Val Ser Asp Phe 
            20                  25                  30          


Leu Val Ser Asp Glu Asn Leu Gln Lys Met Glu Asn Val Leu Asp Leu 
        35                  40                  45              


Trp Ser Ser Gly Leu Lys Thr Asn Ile Ile Ser Glu Leu Ser Lys Trp 
    50                  55                  60                  


Arg Leu Asn Phe Ile Asp Trp His Arg Met Glu Met Arg Lys Glu Lys 
65                  70                  75                  80  


Glu Lys His Ala Ala His Leu Lys Gln Leu Cys Asn Gln Ile Asn Glu 
                85                  90                  95      


Leu Lys Glu Leu Gln Lys Thr Phe Glu Ile Ser Ile Gly Arg Lys Asp 
            100                 105                 110         


Glu Val Ile Ser Ser Leu Ser His Ala Ile Gly Lys Gln Lys Glu Lys 
        115                 120                 125             


Ile Glu Leu Met Arg Thr Phe Phe His Trp Arg Ile Gly His Val Arg 
    130                 135                 140                 


Ala Arg Gln Asp Val Tyr Glu Gly Lys Leu Ala Asp Gln Tyr Tyr Gln 
145                 150                 155                 160 


Arg Thr 
        


<210> 8357
<211> 136
<212> PRT
<213> Homo sapiens

<400> 8357
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Val Gln His His Gly Tyr Ser Gly 
            100                 105                 110         


Pro Asn Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala Val 
        115                 120                 125             


Ser Leu Leu Leu Arg Tyr Cys Ala 
    130                 135     


<210> 8358
<211> 106
<212> PRT
<213> Homo sapiens

<400> 8358
Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu 
            100                 105     


<210> 8359
<211> 136
<212> PRT
<213> Homo sapiens

<400> 8359
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg Thr Leu Ala Asp 
    130                 135     


<210> 8360
<211> 131
<212> PRT
<213> Homo sapiens

<400> 8360
Met Glu Asp Gly Thr Pro Lys His Ile Ile Gln Met Thr Gly Phe Lys 
1               5                   10                  15      


Met Glu Glu Lys Glu Ala Leu Val Lys Leu Leu Leu Lys Leu Asp Cys 
            20                  25                  30          


Thr Phe Ile Lys Ser Glu Lys Tyr Lys Asn Cys Thr His Leu Ile Ala 
        35                  40                  45              


Glu Arg Leu Cys Lys Ser Glu Lys Phe Leu Ala Ala Cys Ala Ala Gly 
    50                  55                  60                  


Lys Trp Ile Leu Thr Lys Asp Tyr Ile Ile His Ser Ala Lys Ser Gly 
65                  70                  75                  80  


Arg Trp Leu Asp Glu Thr Thr Tyr Glu Trp Gly Tyr Lys Ile Glu Lys 
                85                  90                  95      


Asp Ser Arg Tyr Ser Pro Gln Met Gln Ser Ala Pro Lys Arg Trp Arg 
            100                 105                 110         


Glu Glu Leu Lys Arg Thr Gly Ala Pro Gly Ala Phe His Arg Trp Lys 
        115                 120                 125             


Val Val Leu 
    130     


<210> 8361
<211> 555
<212> PRT
<213> Homo sapiens

<400> 8361
Met Arg Leu Ile Gly Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro 
1               5                   10                  15      


Arg Arg Ile Tyr Thr Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys 
            20                  25                  30          


Lys Ser His Trp Ala Glu Leu Glu Ile Ser Gly Arg Val Arg Ser Leu 
        35                  40                  45              


Ser Thr Ser Leu Trp Ser Leu Thr His Leu Thr Ala Leu His Leu Asn 
    50                  55                  60                  


Asp Asn Tyr Leu Ser Arg Ile Pro Pro Asp Ile Ala Lys Leu His Asn 
65                  70                  75                  80  


Leu Val Tyr Leu Asp Leu Ser Ser Asn Lys Leu Arg Ser Leu Pro Ala 
                85                  90                  95      


Glu Leu Gly Asn Met Val Ser Leu Arg Glu Leu Leu Leu Asn Asn Asn 
            100                 105                 110         


Leu Leu Arg Val Leu Pro Tyr Glu Leu Gly Arg Leu Phe Gln Leu Gln 
        115                 120                 125             


Thr Leu Gly Leu Lys Gly Asn Pro Leu Ser Gln Asp Ile Leu Asn Leu 
    130                 135                 140                 


Tyr Gln Asp Pro Asp Gly Thr Arg Lys Leu Leu Asn Phe Met Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Val His Pro Glu Gln Leu Pro Pro Arg Pro Trp Ile Thr 
                165                 170                 175     


Leu Lys Glu Arg Asp Gln Ile Leu Pro Ser Ala Ser Phe Thr Val Met 
            180                 185                 190         


Cys Tyr Asn Val Leu Cys Asp Lys Tyr Ala Thr Arg Gln Leu Tyr Gly 
        195                 200                 205             


Tyr Cys Pro Ser Trp Ala Leu Asn Trp Glu Tyr Arg Lys Lys Gly Ile 
    210                 215                 220                 


Met Glu Glu Ile Val Asn Cys Asp Ala Asp Ile Ile Ser Leu Gln Glu 
225                 230                 235                 240 


Val Glu Thr Glu Gln Tyr Phe Thr Leu Phe Leu Pro Ala Leu Lys Glu 
                245                 250                 255     


Arg Gly Tyr Asp Gly Phe Phe Ser Pro Lys Ser Arg Ala Lys Ile Met 
            260                 265                 270         


Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys 
        275                 280                 285             


Thr Glu Lys Phe Thr Leu Val Gln Lys His Thr Val Glu Phe Asn Gln 
    290                 295                 300                 


Val Ala Met Ala Asn Ser Asp Gly Ser Glu Ala Met Leu Asn Arg Val 
305                 310                 315                 320 


Met Thr Lys Asp Asn Ile Gly Val Ala Val Val Leu Glu Val His Lys 
                325                 330                 335     


Glu Leu Phe Gly Ala Gly Met Lys Pro Ile His Ala Ala Asp Lys Gln 
            340                 345                 350         


Leu Leu Ile Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr Ser 
        355                 360                 365             


Asp Val Lys Leu Ile Gln Thr Met Met Phe Val Ser Glu Val Lys Asn 
    370                 375                 380                 


Ile Leu Glu Lys Ala Ser Ser Arg Pro Gly Ser Pro Thr Ala Asp Pro 
385                 390                 395                 400 


Asn Ser Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu Pro Asp 
                405                 410                 415     


Ser Gly Val Val Glu Tyr Leu Ser Asn Gly Gly Val Ala Asp Asn His 
            420                 425                 430         


Lys Asp Phe Lys Glu Leu Arg Tyr Asn Glu Cys Leu Met Asn Phe Ser 
        435                 440                 445             


Cys Asn Gly Lys Asn Gly Ser Ser Glu Gly Arg Ile Thr His Gly Phe 
    450                 455                 460                 


Gln Leu Lys Ser Ala Tyr Glu Asn Asn Leu Met Pro Tyr Thr Asn Tyr 
465                 470                 475                 480 


Thr Phe Asp Phe Lys Gly Val Ile Asp Tyr Ile Phe Tyr Ser Lys Thr 
                485                 490                 495     


His Met Asn Val Leu Gly Val Leu Gly Pro Leu Asp Pro Gln Trp Leu 
            500                 505                 510         


Val Glu Asn Asn Ile Thr Gly Cys Pro His Pro His Ile Pro Ser Asp 
        515                 520                 525             


His Phe Ser Leu Leu Thr Gln Leu Glu Leu His Pro Pro Leu Leu Pro 
    530                 535                 540                 


Leu Val Asn Gly Val His Leu Pro Asn Arg Arg 
545                 550                 555 


<210> 8362
<211> 544
<212> PRT
<213> Homo sapiens

<400> 8362
Met Asn Thr Ser Ile Pro Tyr Gln Gln Asn Pro Tyr Asn Pro Arg Gly 
1               5                   10                  15      


Ser Ser Asn Val Ile Gln Cys Tyr Arg Cys Gly Asp Thr Cys Lys Gly 
            20                  25                  30          


Glu Val Val Arg Val His Asn Asn His Phe His Ile Arg Cys Phe Thr 
        35                  40                  45              


Cys Gln Val Cys Gly Cys Gly Leu Ala Gln Ser Gly Phe Phe Phe Lys 
    50                  55                  60                  


Asn Gln Glu Tyr Ile Cys Thr Gln Asp Tyr Gln Gln Leu Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys Asp Ser Cys Arg Asp Phe Ile Thr Gly Glu Val Ile Ser Ala 
                85                  90                  95      


Leu Gly Arg Thr Tyr His Pro Lys Cys Phe Val Cys Ser Leu Cys Arg 
            100                 105                 110         


Lys Pro Phe Pro Ile Gly Asp Lys Val Thr Phe Ser Gly Lys Glu Cys 
        115                 120                 125             


Val Cys Gln Thr Cys Ser Gln Ser Met Ala Ser Ser Lys Pro Ile Lys 
    130                 135                 140                 


Ile Arg Gly Pro Ser His Cys Ala Gly Cys Lys Glu Glu Ile Lys His 
145                 150                 155                 160 


Gly Gln Ser Leu Leu Ala Leu Asp Lys Gln Trp His Val Ser Cys Phe 
                165                 170                 175     


Lys Cys Gln Thr Cys Ser Val Ile Leu Thr Gly Glu Tyr Ile Ser Lys 
            180                 185                 190         


Asp Gly Val Pro Tyr Cys Glu Ser Asp Tyr His Ala Gln Phe Gly Ile 
        195                 200                 205             


Lys Cys Glu Thr Cys Asp Arg Tyr Ile Ser Gly Arg Val Leu Glu Ala 
    210                 215                 220                 


Gly Gly Lys His Tyr His Pro Thr Cys Ala Arg Cys Val Arg Cys His 
225                 230                 235                 240 


Gln Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Thr Gly Ser Glu Val 
                245                 250                 255     


Trp His Pro Ile Cys Lys Gln Ala Ala Arg Ala Glu Lys Lys Leu Lys 
            260                 265                 270         


His Arg Arg Thr Ser Glu Thr Ser Ile Ser Pro Pro Gly Ser Ser Ile 
        275                 280                 285             


Gly Ser Pro Asn Arg Val Ile Cys Asp Ile Tyr Glu Asn Leu Asp Leu 
    290                 295                 300                 


Arg Gln Arg Arg Ala Ser Ser Pro Gly Tyr Ile Asp Ser Pro Thr Tyr 
305                 310                 315                 320 


Ser Arg Gln Gly Met Ser Pro Thr Phe Ser Arg Ser Pro His His Tyr 
                325                 330                 335     


Tyr Arg Ser Gly Asp Leu Ser Thr Ala Thr Lys Ser Lys Thr Ser Glu 
            340                 345                 350         


Asp Ile Ser Gln Thr Ser Lys Tyr Ser Pro Ile Tyr Ser Pro Asp Pro 
        355                 360                 365             


Tyr Tyr Ala Ser Glu Ser Glu Tyr Trp Thr Tyr His Gly Ser Pro Lys 
    370                 375                 380                 


Val Pro Arg Ala Arg Arg Phe Ser Ser Gly Gly Glu Glu Asp Asp Phe 
385                 390                 395                 400 


Asp Arg Ser Met His Lys Leu Gln Ser Gly Ile Gly Arg Leu Ile Leu 
                405                 410                 415     


Lys Glu Glu Met Lys Ala Arg Ser Ser Ser Tyr Ala Asp Pro Trp Thr 
            420                 425                 430         


Pro Pro Arg Ser Ser Thr Ser Ser Arg Glu Ala Leu His Thr Ala Gly 
        435                 440                 445             


Tyr Glu Met Ser Leu Asn Gly Ser Pro Arg Ser His Tyr Leu Ala Asp 
    450                 455                 460                 


Ser Asp Pro Leu Ile Ser Lys Ser Ala Ser Leu Pro Ala Tyr Arg Arg 
465                 470                 475                 480 


Asn Gly Leu His Arg Thr Pro Ser Ala Asp Leu Phe His Tyr Asp Ser 
                485                 490                 495     


Met Asn Ala Val Asn Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr 
            500                 505                 510         


Glu Leu Leu Leu Val Thr Thr Arg Gly Arg Asn Arg Leu Pro Lys Asp 
        515                 520                 525             


Val Asp Arg Thr Arg Leu Glu Gly Asn Phe Trp Lys Ser Gly Cys Leu 
    530                 535                 540                 


<210> 8363
<211> 130
<212> PRT
<213> Homo sapiens

<400> 8363
Met Gly Arg Leu Asp Gly Lys Val Ile Ile Leu Thr Ala Ala Ala Gln 
1               5                   10                  15      


Gly Ile Gly Gln Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Ala Thr Asp Ile Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys 
        35                  40                  45              


Tyr Pro Gly Ile Gln Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gln 
    50                  55                  60                  


Ile Asp Gln Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn 
65                  70                  75                  80  


Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys 
                85                  90                  95      


Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met 
            100                 105                 110         


Ile Lys Ala Phe Leu Pro Lys Met Leu Ala Gln Lys Ser Gly Asn Ile 
        115                 120                 125             


Ile Asn 
    130 


<210> 8364
<211> 372
<212> PRT
<213> Homo sapiens

<400> 8364
Met Gln Gly Pro Ala Gly Asn Ala Ser Arg Gly Leu Pro Gly Gly Pro 
1               5                   10                  15      


Pro Ser Thr Val Ala Ser Gly Ala Gly Arg Cys Glu Ser Gly Ala Leu 
            20                  25                  30          


Met His Ser Phe Gly Ile Phe Leu Gln Gly Leu Leu Gly Val Val Ala 
        35                  40                  45              


Phe Ser Thr Leu Met Leu Lys Arg Phe Arg Glu Pro Lys His Glu Arg 
    50                  55                  60                  


Arg Pro Trp Arg Ile Trp Phe Leu Asp Thr Ser Lys Gln Ala Ile Gly 
65                  70                  75                  80  


Met Leu Phe Ile His Phe Ala Asn Val Tyr Leu Ala Asp Leu Thr Glu 
                85                  90                  95      


Glu Asp Pro Cys Ser Leu Tyr Leu Ile Asn Phe Leu Leu Asp Ala Thr 
            100                 105                 110         


Val Gly Met Leu Leu Ile Tyr Val Gly Val Arg Ala Val Ser Val Leu 
        115                 120                 125             


Val Glu Trp Gln Gln Trp Glu Ser Leu Arg Phe Gly Glu Tyr Gly Asp 
    130                 135                 140                 


Pro Leu Gln Cys Gly Ala Trp Val Gly Gln Cys Ala Leu Tyr Ile Val 
145                 150                 155                 160 


Ile Met Ile Phe Glu Lys Ser Val Val Phe Ile Val Leu Leu Ile Leu 
                165                 170                 175     


Gln Trp Lys Lys Val Ala Leu Leu Asn Pro Ile Glu Asn Pro Asp Leu 
            180                 185                 190         


Lys Leu Ala Ile Val Met Leu Ile Val Pro Phe Phe Val Asn Ala Leu 
        195                 200                 205             


Met Phe Trp Val Val Asp Asn Phe Leu Met Arg Lys Gly Lys Thr Lys 
    210                 215                 220                 


Ala Lys Leu Glu Glu Arg Gly Ala Asn Gln Asp Ser Arg Asn Gly Ser 
225                 230                 235                 240 


Lys Val Arg Tyr Arg Arg Ala Ala Ser His Glu Glu Ser Glu Ser Glu 
                245                 250                 255     


Ile Leu Ile Ser Ala Asp Asp Glu Met Glu Glu Ser Asp Val Glu Glu 
            260                 265                 270         


Asp Leu Arg Arg Leu Thr Pro Leu Lys Pro Val Lys Lys Lys Lys His 
        275                 280                 285             


Arg Phe Gly Leu Pro Ala Gly Ala Gln Glu Ala Pro Ile Lys Lys Lys 
    290                 295                 300                 


Arg Pro Pro Val Lys Asp Glu Asp Leu Lys Gly Ala Arg Gly Asn Leu 
305                 310                 315                 320 


Thr Lys Asn Gln Glu Ile Lys Ser Lys Thr Tyr Gln Val Met Arg Glu 
                325                 330                 335     


Cys Glu Gln Ala Gly Ser Ala Ala Pro Ser Val Phe Ser Arg Thr Arg 
            340                 345                 350         


Thr Gly Thr Glu Thr Val Phe Glu Lys Pro Lys Ala Gly Pro Thr Lys 
        355                 360                 365             


Ser Val Phe Gly 
    370         


<210> 8365
<211> 168
<212> PRT
<213> Homo sapiens

<400> 8365
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala 
                165             


<210> 8366
<211> 2
<212> PRT
<213> Homo sapiens

<400> 8366
Met Ala 
1       


<210> 8367
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8367
Met Thr Thr Val Val Val His Val Asp Ser Lys Ala Glu Leu Thr Thr 
1               5                   10                  15      


Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val 
            20                  25                  30          


Pro Ile Leu Thr Arg Met Ser Gln Leu Ile Glu Lys Glu Thr Glu Glu 
        35                  40                  45              


Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg 
    50                  55                  60                  


Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys 
65                  70                  75                  80  


Asn Asp Asp Phe Met Asn Ala Leu Val Asn Ala Tyr Val Met Thr Ser 
                85                  90                  95      


Arg Glu Pro Pro Leu Asn Thr Ala Ala Cys Arg Leu Leu Leu Asp Ile 
            100                 105                 110         


Met Pro Gly Leu Glu Thr Ala Val Val Phe Gln Glu Lys Glu Gly Ile 
        115                 120                 125             


Val Glu Asn Leu Phe Lys Trp Ala Arg Glu Ala Asp Gln Pro Leu Arg 
    130                 135                 140                 


Thr Tyr Ser Thr Gly Leu Leu Gly Gly Ala Met Glu Asn Gln Asp Ile 
145                 150                 155                 160 


Ala Ala Asn Tyr Arg Asp Glu Asn Ser Gln Leu Val Ala Ile Val Leu 
                165                 170                 175     


Arg Arg Leu Arg Glu Leu Gln Leu Gln Glu Val Ala Leu Arg Gln Glu 
            180                 185                 190         


Asn Lys Arg Pro Ser Pro Arg Lys Leu Ser Ser Glu Pro Leu Leu Pro 
        195                 200                 205             


Leu Asp Glu Glu Ala Val Asp Met Asp Tyr Gly Asp Met Ala Val Asp 
    210                 215                 220                 


Val Val Asp Gly Asp Gln Glu Glu Ala Ser Gly Asp Met Glu Ile Ser 
225                 230                 235                 240 


Phe His Leu Asp Ser Gly His Lys Thr Ser Ser Arg Val Asn Ser Thr 
                245                 250                 255     


Thr Lys Pro Glu Asp Gly Gly Leu Lys Lys Asn Lys Ser Ala Lys Gln 
            260                 265                 270         


Gly Asp Arg Glu Asn Phe Arg Lys Ala Lys Gln Lys Leu Gly Phe Ser 
        275                 280                 285             


Ser Ser Asp Pro Asp Arg Met Phe Val Glu Leu Ser Asn Ser Ser Trp 
    290                 295                 300                 


Ser Glu Met Ser Pro Trp Val Ile Gly Thr Asn Tyr Thr Leu Tyr Pro 
305                 310                 315                 320 


Met Thr Pro Ala Ile Glu Gln Arg Leu Ile Leu Gln Tyr Leu Thr Pro 
                325                 330                 335     


Leu Gly Glu Tyr Gln Glu Leu Leu Pro Ile Phe Met Gln Leu Gly Ser 
            340                 345                 350         


Arg Glu Leu Met Met Phe Tyr Ile Asp Leu Lys Gln Thr Asn Asp Val 
        355                 360                 365             


Leu Leu Thr Phe Glu Ala Leu Lys 
    370                 375     


<210> 8368
<211> 167
<212> PRT
<213> Homo sapiens

<400> 8368
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Thr Ser Asp Arg Asp Ile Cys Tyr Arg Cys Gly 
        35                  40                  45              


Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys 
    50                  55                  60                  


Tyr Asn Cys Gly Arg Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro 
65                  70                  75                  80  


Lys Arg Glu Arg Glu Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His 
                85                  90                  95      


Leu Ala Arg Asp Cys Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys 
            100                 105                 110         


Gly Glu Phe Gly His Ile Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr 
        115                 120                 125             


Arg Cys Gly Glu Thr Gly His Val Ala Ile Asn Cys Ser Lys Thr Ser 
    130                 135                 140                 


Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu 
145                 150                 155                 160 


Cys Thr Ile Glu Ala Thr Ala 
                165         


<210> 8369
<211> 332
<212> PRT
<213> Homo sapiens

<400> 8369
Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro 
        35                  40                  45              


Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys 
    50                  55                  60                  


Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp 
65                  70                  75                  80  


Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val 
                85                  90                  95      


Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly 
            100                 105                 110         


Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu 
        115                 120                 125             


Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr 
            260                 265                 270         


Gly Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro 
        275                 280                 285             


Gly Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly 
    290                 295                 300                 


Pro Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln 
305                 310                 315                 320 


Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
                325                 330         


<210> 8370
<211> 204
<212> PRT
<213> Homo sapiens

<400> 8370
Met Ser Asp Leu Arg Ile Thr Glu Ala Phe Leu Tyr Met Asp Tyr Leu 
1               5                   10                  15      


Cys Phe Arg Ala Leu Cys Cys Lys Gly Pro Pro Pro Ala Arg Pro Glu 
            20                  25                  30          


Tyr Asp Leu Val Cys Ile Gly Leu Thr Gly Ser Gly Lys Thr Ser Leu 
        35                  40                  45              


Leu Ser Lys Leu Cys Ser Glu Ser Pro Asp Asn Val Val Ser Thr Thr 
    50                  55                  60                  


Gly Phe Ser Ile Lys Ala Val Pro Phe Gln Asn Ala Ile Leu Asn Val 
65                  70                  75                  80  


Lys Glu Leu Gly Gly Ala Asp Asn Ile Arg Lys Tyr Trp Ser Arg Tyr 
                85                  90                  95      


Tyr Gln Gly Ser Gln Gly Val Ile Phe Val Leu Asp Ser Ala Ser Ser 
            100                 105                 110         


Glu Asp Asp Leu Glu Ala Ala Arg Asn Glu Leu His Ser Ala Leu Gln 
        115                 120                 125             


His Pro Gln Leu Cys Thr Leu Pro Phe Leu Ile Leu Ala Asn His Gln 
    130                 135                 140                 


Asp Lys Pro Ala Ala Arg Ser Val Gln Glu Ile Lys Lys Tyr Phe Glu 
145                 150                 155                 160 


Leu Glu Pro Leu Ala Arg Gly Lys Arg Trp Ile Leu Gln Pro Cys Ser 
                165                 170                 175     


Leu Asp Asp Met Asp Ala Leu Lys Asp Ser Phe Ser Gln Leu Ile Asn 
            180                 185                 190         


Leu Leu Glu Glu Lys Asp His Glu Ala Val Arg Met 
        195                 200                 


<210> 8371
<211> 2104
<212> PRT
<213> Homo sapiens

<400> 8371
Met Glu Ser Gln Glu Phe Ile Val Leu Tyr Thr His Gln Lys Met Lys 
1               5                   10                  15      


Lys Ser Lys Val Trp Gln Asp Gly Ile Leu Lys Ile Thr His Leu Gly 
            20                  25                  30          


Asn Lys Ala Ile Leu Tyr Asp Asp Lys Gly Ala Cys Leu Glu Ser Leu 
        35                  40                  45              


Phe Leu Lys Cys Leu Glu Val Lys Pro Gly Asp Asp Leu Glu Ser Asp 
    50                  55                  60                  


Arg Tyr Leu Ile Thr Val Glu Glu Val Lys Val Ala Gly Ala Ile Gly 
65                  70                  75                  80  


Ile Val Lys Gln Asn Val Asn Lys Glu Ala Pro Glu Leu Asn Ser Arg 
                85                  90                  95      


Thr Phe Ile Ser Ser Gly Arg Ser Leu Gly Cys Gln Pro Ser Gly Leu 
            100                 105                 110         


Lys Arg Lys Phe Thr Gly Phe Gln Gly Pro Arg Gln Val Pro Lys Lys 
        115                 120                 125             


Met Val Ile Met Glu Ser Gly Glu Ser Ala Ala Ser His Glu Ala Lys 
    130                 135                 140                 


Lys Thr Gly Pro Thr Ile Phe Ser Pro Phe Cys Ser Met Pro Pro Leu 
145                 150                 155                 160 


Phe Pro Thr Val Gly Lys Lys Asp Val Asn Asn Ile Leu Ala Asp Pro 
                165                 170                 175     


Glu Asn Ile Val Thr Tyr Lys Asn Arg Glu Arg Asn Ala Met Asp Phe 
            180                 185                 190         


Ser Ser Val Phe Ser Pro Ser Phe Gln Ile Asn Pro Glu Val Leu Cys 
        195                 200                 205             


Glu Glu Asn Tyr Phe Cys Ser Pro Val Asn Ser Gly Asn Lys Leu Ser 
    210                 215                 220                 


Asp Ser Leu Leu Thr Asn Glu Pro Val Lys Arg Asp Ser Leu Ala Ser 
225                 230                 235                 240 


His Tyr Ser Gly Val Ser Gln Asn Ile Arg Ser Lys Ala Gln Ile Leu 
                245                 250                 255     


Ala Leu Leu Lys Ser Glu Ser Ser Ser Ser Cys Glu Glu Leu Asn Ser 
            260                 265                 270         


Glu Met Thr Glu His Phe Pro Gln Lys Gln Pro Gln Gly Ser Leu Lys 
        275                 280                 285             


Ile Ala Thr Lys Pro Lys Tyr Leu Ile Gln Gln Glu Glu Cys Ala Glu 
    290                 295                 300                 


Met Lys Ser Thr Glu Asn Leu Tyr Tyr Gln His Gln Ser Glu Asn Thr 
305                 310                 315                 320 


Met Arg Asn Lys Ser Arg Trp Ala Met Tyr Leu Ser Ser Gln Ser Ser 
                325                 330                 335     


Pro Ile His Ser Ser Thr Val Asp Gly Asn Asp Thr Glu Arg Lys Pro 
            340                 345                 350         


Lys Ala Gln Glu Asp Asp Val Asn Ser Asn Leu Lys Asp Leu Ser Leu 
        355                 360                 365             


Gln Lys Ile Ile Gln Phe Val Glu Thr Tyr Ala Glu Glu Arg Lys Lys 
    370                 375                 380                 


Tyr Asn Val Asp Gln Ser Val Gly Asn Asn Asp Pro Ser Trp Asn Gln 
385                 390                 395                 400 


Glu Val Lys Leu Glu Ile Pro Ser Phe Asn Glu Ser Ser Ser Leu Gln 
                405                 410                 415     


Val Thr Cys Ser Ser Ala Glu Asn Asp Gly Ile Leu Ser Glu Ser Asp 
            420                 425                 430         


Ile Gln Glu Asp Asn Lys Ile Pro Phe Asn Gln Asn Asp Lys Gly Cys 
        435                 440                 445             


Ile Lys Gly Ser Val Leu Ile Lys Glu Asn Ala Gln Glu Val Asn Thr 
    450                 455                 460                 


Cys Gly Thr Leu Glu Lys Glu Tyr Glu Gln Ser Glu Ser Ser Leu Pro 
465                 470                 475                 480 


Glu Leu Lys His Leu Gln Ile Glu Ser Ser Asn Asn Ser Arg Ile Ser 
                485                 490                 495     


Asp Asp Ile Thr Asp Met Ile Ser Glu Ser Lys Met Asp Asn Glu Ser 
            500                 505                 510         


Leu Asn Ser Ile His Glu Ser Leu Ser Asn Val Thr Gln Pro Phe Leu 
        515                 520                 525             


Glu Val Thr Phe Asn Leu Asn Asn Phe Glu Thr Ser Asp Thr Glu Glu 
    530                 535                 540                 


Glu Ser Gln Glu Ser Asn Lys Ile Ser Gln Asp Ser Glu Ser Trp Val 
545                 550                 555                 560 


Lys Asp Ile Leu Val Asn Asp Gly Asn Ser Cys Phe Gln Lys Arg Ser 
                565                 570                 575     


Glu Asn Thr Asn Cys Glu Glu Ile Glu Gly Glu His Leu Pro Phe Leu 
            580                 585                 590         


Thr Ser Val Ser Asp Lys Pro Thr Val Thr Phe Pro Val Lys Glu Thr 
        595                 600                 605             


Leu Pro Ser Gln Phe Cys Asp Lys Thr Tyr Val Gly Phe Asp Met Gly 
    610                 615                 620                 


Ile Cys Lys Thr Glu Asn Thr Gly Lys Glu Ile Glu Glu Tyr Ser Asp 
625                 630                 635                 640 


Thr Leu Ser Asn Phe Glu Ser Phe Lys Trp Thr Asp Ala Val Tyr Gly 
                645                 650                 655     


Asp Asn Lys Glu Asp Ala Asn Lys Pro Ile Gln Glu Val Arg Ile Asn 
            660                 665                 670         


Tyr Asp Phe Ala Leu Pro Pro Asn Lys Ser Lys Gly Ile Asn Met Asn 
        675                 680                 685             


Leu His Ile Pro His Ile Gln Asn Gln Ile Ala Glu Asn Ser Asn Leu 
    690                 695                 700                 


Phe Ser Glu Asp Ala Gln Pro Gln Pro Phe Ile Leu Gly Ser Asp Leu 
705                 710                 715                 720 


Asp Lys Asn Asp Glu His Val Leu Pro Ser Thr Ser Ser Ser Asp Asn 
                725                 730                 735     


Ser Val Gln Leu Leu Asn Thr Asn Gln Asn His Tyr Glu Cys Ile Ala 
            740                 745                 750         


Leu Asp Lys Ser Asn Thr His Ile Ser Asn Ser Leu Phe Tyr Pro Leu 
        755                 760                 765             


Gly Lys Lys His Leu Ile Ser Lys Asp Thr Glu Ala His Ile Ser Glu 
    770                 775                 780                 


Pro Glu Asp Leu Gly Lys Ile Arg Ser Pro Pro Pro Asp His Val Glu 
785                 790                 795                 800 


Val Glu Thr Ala Arg Glu Gly Lys Gln Tyr Trp Asn Pro Arg Asn Ser 
                805                 810                 815     


Ser Glu Leu Ser Gly Leu Val Asn Thr Ile Ser Ile Leu Lys Ser Leu 
            820                 825                 830         


Cys Glu His Ser Thr Ala Leu Asp Ser Leu Glu Ile Leu Lys Lys Lys 
        835                 840                 845             


Asn Thr Val Phe Gln Gln Gly Thr Gln Gln Thr Tyr Glu Pro Asp Ser 
    850                 855                 860                 


Pro Pro Glu Val Arg Lys Pro Phe Ile Thr Val Val Ser Pro Lys Ser 
865                 870                 875                 880 


Pro His Leu His Lys Asp Ser Gln Gln Ile Leu Lys Glu Asp Glu Val 
                885                 890                 895     


Glu Leu Ser Glu Pro Leu Gln Ser Val Gln Phe Ser Ser Ser Gly Ser 
            900                 905                 910         


Lys Glu Glu Thr Ala Phe Gln Ala Val Ile Pro Lys Gln Ile Glu Arg 
        915                 920                 925             


Lys Thr Cys Asp Pro Lys Pro Val Glu Phe Gln Gly His Gln Val Lys 
    930                 935                 940                 


Gly Ser Ala Thr Ser Gly Val Met Val Arg Gly His Ser Ser Gln Leu 
945                 950                 955                 960 


Gly Cys Ser Gln Phe Pro Asp Ser Thr Glu Tyr Glu Asn Phe Met Thr 
                965                 970                 975     


Glu Thr Pro Glu Leu Pro Ser Thr Cys Met Gln Ile Asp Phe Leu Gln 
            980                 985                 990         


Val Thr Ser Pro Glu Glu Asn Ile  Ser Thr Leu Ser Pro  Val Ser Thr 
        995                 1000                 1005             


Phe Ser  Leu Asn Ser Arg Asp  Glu Asp Phe Met Val  Glu Phe Ser 
    1010                 1015                 1020             


Glu Thr  Ser Leu Lys Ala Arg  Thr Leu Pro Asp Asp  Leu His Phe 
    1025                 1030                 1035             


Leu Asn  Leu Glu Gly Met Lys  Lys Ser Arg Ser Leu  Glu Asn Glu 
    1040                 1045                 1050             


Asn Leu  Gln Arg Leu Ser Leu  Leu Ser Arg Thr Gln  Val Pro Leu 
    1055                 1060                 1065             


Ile Thr  Leu Pro Arg Thr Asp  Gly Pro Pro Asp Leu  Asp Ser His 
    1070                 1075                 1080             


Ser Tyr  Met Ile Asn Ser Asn  Thr Tyr Glu Ser Ser  Gly Ser Pro 
    1085                 1090                 1095             


Met Leu  Asn Leu Cys Glu Lys  Ser Ala Val Leu Ser  Phe Ser Ile 
    1100                 1105                 1110             


Glu Pro  Glu Asp Gln Asn Glu  Thr Phe Phe Ser Glu  Glu Ser Arg 
    1115                 1120                 1125             


Glu Val  Asn Pro Gly Asp Val  Ser Leu Asn Asn Ile  Ser Thr Gln 
    1130                 1135                 1140             


Ser Lys  Trp Leu Lys Tyr Gln  Asn Thr Ser Gln Cys  Asn Val Ala 
    1145                 1150                 1155             


Thr Pro  Asn Arg Val Asp Lys  Arg Ile Thr Asp Gly  Phe Phe Ala 
    1160                 1165                 1170             


Glu Ala  Val Ser Gly Met His  Phe Arg Asp Thr Ser  Glu Arg Gln 
    1175                 1180                 1185             


Ser Asp  Ala Val Asn Glu Ser  Ser Leu Asp Ser Val  His Leu Gln 
    1190                 1195                 1200             


Met Ile  Lys Gly Met Leu Tyr  Gln Gln Arg Gln Asp  Phe Ser Ser 
    1205                 1210                 1215             


Gln Asp  Ser Val Ser Arg Lys  Lys Val Leu Ser Leu  Asn Leu Lys 
    1220                 1225                 1230             


Gln Thr  Ser Lys Thr Glu Glu  Ile Lys Asn Val Leu  Gly Gly Ser 
    1235                 1240                 1245             


Thr Cys  Tyr Asn Tyr Ser Val  Lys Asp Leu Gln Glu  Ile Ser Gly 
    1250                 1255                 1260             


Ser Glu  Leu Cys Phe Pro Ser  Gly Gln Lys Ile Lys  Ser Ala Tyr 
    1265                 1270                 1275             


Leu Pro  Gln Arg Gln Ile His  Ile Pro Ala Val Phe  Gln Ser Pro 
    1280                 1285                 1290             


Ala His  Tyr Lys Gln Thr Phe  Thr Ser Cys Leu Ile  Glu His Leu 
    1295                 1300                 1305             


Asn Ile  Leu Leu Phe Gly Leu  Ala Gln Asn Leu Gln  Lys Ala Leu 
    1310                 1315                 1320             


Ser Lys  Val Asp Ile Ser Phe  Tyr Thr Ser Leu Lys  Gly Glu Lys 
    1325                 1330                 1335             


Leu Lys  Asn Ala Glu Asn Asn  Val Pro Ser Cys His  His Ser Gln 
    1340                 1345                 1350             


Pro Ala  Lys Leu Val Met Val  Lys Lys Glu Gly Pro  Asn Lys Gly 
    1355                 1360                 1365             


Arg Leu  Phe Tyr Thr Cys Asp  Gly Pro Lys Ala Asp  Arg Cys Lys 
    1370                 1375                 1380             


Phe Phe  Lys Trp Leu Glu Asp  Val Thr Pro Gly Tyr  Ser Thr Gln 
    1385                 1390                 1395             


Glu Gly  Ala Arg Pro Gly Met  Val Leu Ser Asp Ile  Lys Ser Ile 
    1400                 1405                 1410             


Gly Leu  Tyr Leu Arg Ser Gln  Lys Ile Pro Leu Tyr  Glu Glu Cys 
    1415                 1420                 1425             


Gln Leu  Leu Val Arg Lys Gly  Phe Asp Phe Gln Arg  Lys Gln Tyr 
    1430                 1435                 1440             


Gly Lys  Leu Lys Lys Phe Thr  Thr Val Asn Pro Glu  Phe Tyr Asn 
    1445                 1450                 1455             


Glu Pro  Lys Thr Lys Leu Tyr  Leu Lys Leu Ser Arg  Lys Glu Arg 
    1460                 1465                 1470             


Ser Ser  Ala Tyr Ser Lys Asn  Asp Leu Trp Val Val  Ser Lys Thr 
    1475                 1480                 1485             


Leu Asp  Phe Glu Leu Asp Thr  Phe Ile Ala Cys Ser  Ala Phe Phe 
    1490                 1495                 1500             


Gly Pro  Ser Ser Ile Asn Glu  Ile Glu Ile Leu Pro  Leu Lys Gly 
    1505                 1510                 1515             


Tyr Phe  Pro Ser Asn Trp Pro  Thr Asn Met Val Val  His Ala Leu 
    1520                 1525                 1530             


Leu Val  Cys Asn Ala Ser Thr  Glu Leu Thr Thr Leu  Lys Asn Ile 
    1535                 1540                 1545             


Gln Asp  Tyr Phe Asn Pro Ala  Thr Leu Pro Leu Thr  Gln Tyr Leu 
    1550                 1555                 1560             


Leu Thr  Thr Ser Ser Pro Thr  Ile Val Ser Asn Lys  Arg Val Ser 
    1565                 1570                 1575             


Lys Arg  Lys Phe Ile Pro Pro  Ala Phe Thr Asn Val  Ser Thr Lys 
    1580                 1585                 1590             


Phe Glu  Leu Leu Ser Leu Gly  Ala Thr Leu Lys Leu  Ala Ser Glu 
    1595                 1600                 1605             


Leu Ile  Gln Val His Lys Leu  Asn Lys Asp Gln Ala  Thr Ala Leu 
    1610                 1615                 1620             


Ile Gln  Ile Ala Gln Met Met  Ala Ser His Glu Ser  Ile Glu Glu 
    1625                 1630                 1635             


Val Lys  Glu Leu Gln Thr His  Thr Phe Pro Ile Thr  Ile Ile His 
    1640                 1645                 1650             


Gly Val  Phe Gly Ala Gly Lys  Ser Tyr Leu Leu Ala  Val Val Ile 
    1655                 1660                 1665             


Leu Phe  Phe Val Gln Leu Phe  Glu Lys Ser Glu Ala  Pro Thr Ile 
    1670                 1675                 1680             


Gly Asn  Ala Arg Pro Trp Lys  Leu Leu Ile Ser Ser  Ser Thr Asn 
    1685                 1690                 1695             


Val Ala  Val Asp Arg Val Leu  Leu Gly Leu Leu Ser  Leu Gly Phe 
    1700                 1705                 1710             


Glu Asn  Phe Ile Arg Val Gly  Ser Val Arg Lys Ile  Ala Lys Pro 
    1715                 1720                 1725             


Ile Leu  Pro Tyr Ser Leu His  Ala Gly Ser Glu Asn  Glu Ser Glu 
    1730                 1735                 1740             


Gln Leu  Lys Glu Leu His Ala  Leu Met Lys Glu Asp  Leu Thr Pro 
    1745                 1750                 1755             


Thr Glu  Arg Val Tyr Val Arg  Lys Ser Ile Glu Gln  His Lys Leu 
    1760                 1765                 1770             


Gly Thr  Asn Arg Thr Leu Leu  Lys Gln Val Arg Val  Val Gly Val 
    1775                 1780                 1785             


Thr Cys  Ala Ala Cys Pro Phe  Pro Cys Met Asn Asp  Leu Lys Phe 
    1790                 1795                 1800             


Pro Val  Val Val Leu Asp Glu  Cys Ser Gln Ile Thr  Glu Pro Ala 
    1805                 1810                 1815             


Ser Leu  Leu Pro Ile Ala Arg  Phe Glu Cys Glu Lys  Leu Ile Leu 
    1820                 1825                 1830             


Val Gly  Asp Pro Lys Gln Leu  Pro Pro Thr Ile Gln  Gly Ser Asp 
    1835                 1840                 1845             


Ala Ala  His Glu Asn Gly Leu  Glu Gln Thr Leu Phe  Asp Arg Leu 
    1850                 1855                 1860             


Cys Leu  Met Gly His Lys Pro  Ile Leu Leu Arg Thr  Gln Tyr Arg 
    1865                 1870                 1875             


Cys His  Pro Ala Ile Ser Ala  Ile Ala Asn Asp Leu  Phe Tyr Lys 
    1880                 1885                 1890             


Gly Ala  Leu Met Asn Gly Val  Thr Glu Ile Glu Arg  Ser Pro Leu 
    1895                 1900                 1905             


Leu Glu  Trp Leu Pro Thr Leu  Cys Phe Tyr Asn Val  Lys Gly Leu 
    1910                 1915                 1920             


Glu Gln  Ile Glu Arg Asp Asn  Ser Phe His Asn Val  Ala Glu Ala 
    1925                 1930                 1935             


Thr Phe  Thr Leu Lys Leu Ile  Gln Ser Leu Ile Ala  Ser Gly Ile 
    1940                 1945                 1950             


Ala Gly  Ser Met Ile Gly Val  Ile Thr Leu Tyr Lys  Ser Gln Met 
    1955                 1960                 1965             


Tyr Lys  Leu Cys His Leu Leu  Ser Ala Val Asp Phe  His His Pro 
    1970                 1975                 1980             


Asp Ile  Lys Thr Val Gln Val  Ser Thr Val Asp Ala  Phe Gln Gly 
    1985                 1990                 1995             


Ala Glu  Lys Glu Ile Ile Ile  Leu Ser Cys Val Arg  Thr Arg Gln 
    2000                 2005                 2010             


Val Gly  Phe Ile Asp Ser Glu  Lys Arg Met Asn Val  Ala Leu Thr 
    2015                 2020                 2025             


Arg Gly  Lys Arg His Leu Leu  Ile Val Gly Asn Leu  Ala Cys Leu 
    2030                 2035                 2040             


Arg Lys  Asn Gln Leu Trp Gly  Arg Val Ile Gln His  Cys Glu Gly 
    2045                 2050                 2055             


Arg Glu  Asp Gly Leu Gln His  Ala Asn Gln Tyr Glu  Pro Gln Leu 
    2060                 2065                 2070             


Asn His  Leu Leu Lys Asp Tyr  Phe Glu Lys Gln Val  Glu Glu Lys 
    2075                 2080                 2085             


Gln Lys  Lys Lys Ser Glu Lys  Glu Lys Ser Lys Asp  Lys Ser His 
    2090                 2095                 2100             


Ser 
    


<210> 8372
<211> 188
<212> PRT
<213> Homo sapiens

<400> 8372
Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Tyr Asp Gln Val Leu Glu Thr Ala Gly 
            180                 185             


<210> 8373
<211> 112
<212> PRT
<213> Homo sapiens

<400> 8373
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


<210> 8374
<211> 120
<212> PRT
<213> Homo sapiens

<400> 8374
Met Trp Lys Val Val Asn Leu Pro Thr Asp Leu Phe Asn Ser Val Met 
1               5                   10                  15      


Asn Val Gly Arg Phe Thr Glu Glu Ile Glu Trp Leu Lys Phe Leu Ala 
            20                  25                  30          


Leu Ala Cys Ser Ala Leu Gly Val Thr Ile Thr Lys Thr Leu Lys Ile 
        35                  40                  45              


Val Cys Glu Val Leu Ser Cys Asp His Asn Gly Gly Leu Pro Arg Ile 
    50                  55                  60                  


Pro Phe Ser Thr Phe Gln Phe Leu Tyr Thr Tyr Ile Ala Glu Val Asp 
65                  70                  75                  80  


Gly Glu Ile Cys Ala Ser His Val Ser Arg Met Leu Asn Tyr Ile Glu 
                85                  90                  95      


Gln Glu Val Ile Gly Pro Asp Gly Leu Ile Thr Val Asn Asp Phe Thr 
            100                 105                 110         


Gln Asn Pro Arg Val Trp Leu Glu 
        115                 120 


<210> 8375
<211> 829
<212> PRT
<213> Homo sapiens

<400> 8375
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala 
        435                 440                 445             


Gly Asn Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Ser Thr Leu Gln 
625                 630                 635                 640 


Val Gln Glu Lys Ser Asn Thr Trp Ser Trp Gly Ile Leu Lys Met Leu 
                645                 650                 655     


Lys Gly Lys Asp Asp Arg Lys Lys Ser Ile Arg Glu Lys Pro Lys Val 
            660                 665                 670         


Ser Asp Ser Asp Asn Asn Glu Gly Ser Ser Phe Pro Ala Pro Pro Lys 
        675                 680                 685             


Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr Ser Asp 
    690                 695                 700                 


Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val Gly Lys 
705                 710                 715                 720 


Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln Glu Lys 
                725                 730                 735     


Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly Glu Ile Arg 
            740                 745                 750         


Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile Thr Ser Lys Lys Trp 
        755                 760                 765             


Gly Thr Arg Asp Leu Gln Val Lys Pro Gly Glu Ser Leu Glu Val Ile 
    770                 775                 780                 


Gln Thr Thr Asp Asp Thr Lys Val Leu Cys Arg Asn Glu Glu Gly Lys 
785                 790                 795                 800 


Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly Glu Ile 
                805                 810                 815     


Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp 
            820                 825                 


<210> 8376
<211> 264
<212> PRT
<213> Homo sapiens

<400> 8376
Met Pro Asp Ser Ala Pro Ala Met Ala Asp Lys Met Asp Met Ser Leu 
1               5                   10                  15      


Asp Asp Ile Ile Lys Leu Asn Arg Ser Gln Arg Gly Gly Arg Gly Gly 
            20                  25                  30          


Gly Arg Gly Arg Gly Arg Ala Gly Ser Gln Gly Gly Arg Gly Gly Gly 
        35                  40                  45              


Ala Gln Ala Ala Ala Arg Val Asn Arg Gly Gly Gly Pro Ile Arg Asn 
    50                  55                  60                  


Arg Pro Ala Ile Ala Arg Gly Ala Ala Gly Gly Gly Gly Arg Asn Arg 
65                  70                  75                  80  


Pro Ala Pro Tyr Ser Arg Pro Lys Gln Leu Pro Asp Lys Trp Gln His 
                85                  90                  95      


Asp Leu Phe Asp Ser Gly Phe Gly Gly Gly Ala Gly Val Glu Thr Gly 
            100                 105                 110         


Gly Lys Leu Leu Val Ser Asn Leu Asp Phe Gly Val Ser Asp Ala Asp 
        115                 120                 125             


Ile Gln Glu Leu Phe Ala Glu Phe Gly Thr Leu Lys Lys Ala Ala Val 
    130                 135                 140                 


His Tyr Asp Arg Ser Gly Arg Ser Leu Gly Thr Ala Asp Val His Phe 
145                 150                 155                 160 


Glu Arg Lys Ala Asp Ala Leu Lys Ala Met Lys Gln Tyr Asn Gly Val 
                165                 170                 175     


Pro Leu Asp Gly Arg Pro Met Asn Ile Gln Leu Val Thr Ser Gln Ile 
            180                 185                 190         


Asp Ala Gln Arg Arg Pro Ala Gln Ser Val Asn Arg Gly Gly Met Thr 
        195                 200                 205             


Arg Asn Arg Gly Ala Gly Gly Phe Gly Gly Gly Gly Gly Thr Arg Arg 
    210                 215                 220                 


Gly Thr Arg Gly Gly Ala Arg Gly Arg Gly Arg Gly Ala Gly Arg Asn 
225                 230                 235                 240 


Ser Lys Gln Gln Leu Ser Ala Glu Glu Leu Asp Ala Gln Leu Asp Ala 
                245                 250                 255     


Tyr Asn Ala Arg Met Asp Thr Ser 
            260                 


<210> 8377
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8377
Met Ala Lys His Gly Ala Asp Glu Pro Ser Ser Arg Ser Gly Ser Pro 
1               5                   10                  15      


Asp Arg Glu Gly Arg Ala Ser Glu Asp Arg Ser Leu Leu His Gln Arg 
            20                  25                  30          


Leu Ala Val Arg Glu Leu Ile Asp Thr Glu Val Ser Tyr Leu His Met 
        35                  40                  45              


Leu Gln Leu Cys Ala Ser Asp Ile Arg Ser Arg Leu Gln Gln Leu Pro 
    50                  55                  60                  


Gln Gly Asp Leu Asp Val Leu Phe Ser Asn Ile Asp Asp Ile Ile Lys 
65                  70                  75                  80  


Val Asn Ser Arg Phe Leu His Asp Leu Gln Glu Thr Ala Ser Lys Glu 
                85                  90                  95      


Glu Glu Gln Val Gln Leu Val 
            100             


<210> 8378
<211> 212
<212> PRT
<213> Homo sapiens

<400> 8378
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg 
    210         


<210> 8379
<211> 339
<212> PRT
<213> Homo sapiens

<400> 8379
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr Ile 
        115                 120                 125             


Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe Tyr 
    130                 135                 140                 


Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp Gln 
145                 150                 155                 160 


Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg Glu 
                165                 170                 175     


Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn Tyr 
        195                 200                 205             


Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu Lys 
    210                 215                 220                 


Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys Trp 
225                 230                 235                 240 


Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile 
                245                 250                 255     


Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His Cys 
            260                 265                 270         


Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val Val 
        275                 280                 285             


Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile Val 
    290                 295                 300                 


Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln 
305                 310                 315                 320 


Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu 
                325                 330                 335     


Thr Leu Asp 
            


<210> 8380
<211> 1070
<212> PRT
<213> Homo sapiens

<400> 8380
Met Ala Gly Ala Leu Arg Arg Gly Arg Ala Leu Gly Ser Arg Pro Ser 
1               5                   10                  15      


Gly Pro Thr Val Ser Ser Arg Arg Ser Pro Gln Cys Pro Val Ala Gln 
            20                  25                  30          


Glu Gly Leu Gly Ala Arg Ser Arg Pro Arg Val Ala Pro Arg Ser Leu 
        35                  40                  45              


Ala Arg Cys Gly Pro Ser Ser Arg Leu Met Gly Trp Lys Pro Ser Glu 
    50                  55                  60                  


Ala Arg Gly Gln Ser Gln Ser Phe Gln Ala Ser Gly Leu Gln Pro Arg 
65                  70                  75                  80  


Ser Leu Lys Ala Ala Arg Arg Ala Thr Gly Arg Pro Asp Arg Ser Arg 
                85                  90                  95      


Ala Ala Arg Pro Thr Met Asp Pro Ser Ala His Arg Ser Arg Ala Ala 
            100                 105                 110         


Pro Pro Asn Met Asp Pro Asp Pro Gln Ala Gly Val Gln Val Gly Met 
        115                 120                 125             


Arg Val Val Arg Gly Val Asp Trp Lys Trp Gly Gln Gln Asp Gly Gly 
    130                 135                 140                 


Glu Gly Gly Val Gly Thr Val Val Glu Leu Gly Arg His Gly Ser Pro 
145                 150                 155                 160 


Ser Thr Pro Asp Arg Thr Val Val Val Gln Trp Asp Gln Gly Thr Arg 
                165                 170                 175     


Thr Asn Tyr Arg Ala Gly Tyr Gln Gly Ala His Asp Leu Leu Leu Tyr 
            180                 185                 190         


Asp Asn Ala Gln Ile Gly Val Arg His Pro Asn Ile Ile Cys Asp Cys 
        195                 200                 205             


Cys Lys Lys His Gly Leu Arg Gly Met Arg Trp Lys Cys Arg Val Cys 
    210                 215                 220                 


Leu Asp Tyr Asp Leu Cys Thr Gln Cys Tyr Met His Asn Lys His Glu 
225                 230                 235                 240 


Leu Ala His Ala Phe Asp Arg Tyr Glu Thr Ala His Ser Arg Pro Val 
                245                 250                 255     


Thr Leu Ser Pro Arg Gln Gly Leu Pro Arg Ile Pro Leu Arg Gly Ile 
            260                 265                 270         


Phe Gln Gly Ala Lys Val Val Arg Gly Pro Asp Trp Glu Trp Gly Ser 
        275                 280                 285             


Gln Asp Gly Gly Glu Gly Lys Pro Gly Arg Val Val Asp Ile Arg Gly 
    290                 295                 300                 


Trp Asp Val Glu Thr Gly Arg Ser Val Ala Ser Val Thr Trp Ala Asp 
305                 310                 315                 320 


Gly Thr Thr Asn Val Tyr Arg Val Gly His Lys Gly Lys Val Asp Leu 
                325                 330                 335     


Lys Cys Val Gly Glu Ala Ala Gly Gly Phe Tyr Tyr Lys Asp His Leu 
            340                 345                 350         


Pro Arg Leu Gly Lys Pro Ala Glu Leu Gln Arg Arg Val Ser Ala Asp 
        355                 360                 365             


Ser Gln Pro Phe Gln His Gly Asp Lys Val Lys Cys Leu Leu Asp Thr 
    370                 375                 380                 


Asp Val Leu Arg Glu Met Gln Glu Gly His Gly Gly Trp Asn Pro Arg 
385                 390                 395                 400 


Met Ala Glu Phe Ile Gly Gln Thr Gly Thr Val His Arg Ile Thr Asp 
                405                 410                 415     


Arg Gly Asp Val Arg Val Gln Phe Asn His Glu Thr Arg Trp Thr Phe 
            420                 425                 430         


His Pro Gly Ala Leu Thr Lys His His Ser Phe Trp Val Gly Asp Val 
        435                 440                 445             


Val Arg Val Ile Gly Asp Leu Asp Thr Val Lys Arg Leu Gln Ala Gly 
    450                 455                 460                 


His Gly Glu Trp Thr Asp Asp Met Ala Pro Ala Leu Gly Arg Val Gly 
465                 470                 475                 480 


Lys Val Val Lys Val Phe Gly Asp Gly Asn Leu Arg Val Ala Val Ala 
                485                 490                 495     


Gly Gln Arg Trp Thr Phe Ser Pro Ser Cys Leu Val Ala Tyr Arg Pro 
            500                 505                 510         


Glu Glu Asp Ala Asn Leu Asp Val Ala Glu Arg Ala Arg Glu Asn Lys 
        515                 520                 525             


Ser Ser Leu Ser Val Ala Leu Asp Lys Leu Arg Ala Gln Lys Ser Asp 
    530                 535                 540                 


Pro Glu His Pro Gly Arg Leu Val Val Glu Val Ala Leu Gly Asn Ala 
545                 550                 555                 560 


Ala Arg Ala Leu Asp Leu Leu Arg Arg Arg Pro Glu Gln Val Asp Thr 
                565                 570                 575     


Lys Asn Gln Gly Arg Thr Ala Leu Gln Val Ala Ala Tyr Leu Gly Gln 
            580                 585                 590         


Val Glu Leu Ile Arg Leu Leu Leu Gln Ala Arg Ala Gly Val Asp Leu 
        595                 600                 605             


Pro Asp Asp Glu Gly Asn Thr Ala Leu His Tyr Ala Ala Leu Gly Asn 
    610                 615                 620                 


Gln Pro Glu Ala Thr Arg Val Leu Leu Ser Ala Gly Cys Arg Ala Asp 
625                 630                 635                 640 


Ala Ile Asn Ser Thr Gln Ser Thr Ala Leu His Val Ala Val Gln Arg 
                645                 650                 655     


Gly Phe Leu Glu Val Val Arg Ala Leu Cys Glu Arg Gly Cys Asp Val 
            660                 665                 670         


Asn Leu Pro Asp Ala His Ser Asp Thr Pro Leu His Ser Ala Ile Ser 
        675                 680                 685             


Ala Gly Thr Gly Ala Ser Gly Ile Val Glu Val Leu Thr Glu Val Pro 
    690                 695                 700                 


Asn Ile Asp Val Thr Ala Thr Asn Ser Gln Gly Phe Thr Leu Leu His 
705                 710                 715                 720 


His Ala Ser Leu Lys Gly His Ala Leu Ala Val Arg Lys Ile Leu Ala 
                725                 730                 735     


Arg Ala Arg Gln Leu Val Asp Ala Lys Lys Glu Asp Gly Phe Thr Ala 
            740                 745                 750         


Leu His Leu Ala Ala Leu Asn Asn His Arg Glu Val Ala Gln Ile Leu 
        755                 760                 765             


Ile Arg Glu Gly Arg Cys Asp Val Asn Val Arg Asn Arg Lys Leu Gln 
    770                 775                 780                 


Ser Pro Leu His Leu Ala Val Gln Gln Ala His Val Gly Leu Val Pro 
785                 790                 795                 800 


Leu Leu Val Asp Ala Gly Cys Ser Val Asn Ala Glu Asp Glu Glu Gly 
                805                 810                 815     


Asp Thr Ala Leu His Val Ala Leu Gln Arg His Gln Leu Leu Pro Leu 
            820                 825                 830         


Val Ala Asp Gly Ala Gly Gly Asp Pro Gly Pro Leu Gln Leu Leu Ser 
        835                 840                 845             


Arg Leu Gln Ala Ser Gly Leu Pro Gly Ser Ala Glu Leu Thr Val Gly 
    850                 855                 860                 


Ala Ala Val Ala Cys Phe Leu Ala Leu Glu Gly Ala Asp Val Ser Tyr 
865                 870                 875                 880 


Thr Asn His Arg Gly Arg Ser Pro Leu Asp Leu Ala Ala Glu Gly Arg 
                885                 890                 895     


Val Leu Lys Ala Leu Gln Gly Cys Ala Gln Arg Phe Arg Glu Arg Gln 
            900                 905                 910         


Ala Gly Gly Gly Ala Ala Pro Gly Pro Arg Gln Thr Leu Gly Thr Pro 
        915                 920                 925             


Asn Thr Val Thr Asn Leu His Val Gly Ala Ala Pro Gly Pro Glu Ala 
    930                 935                 940                 


Ala Glu Cys Leu Val Cys Ser Glu Leu Ala Leu Leu Val Leu Phe Ser 
945                 950                 955                 960 


Pro Cys Gln His Arg Thr Val Cys Glu Glu Cys Ala Arg Arg Met Lys 
                965                 970                 975     


Lys Cys Ile Arg Cys Gln Val Val Val Ser Lys Lys Leu Arg Pro Asp 
            980                 985                 990         


Gly Ser Glu Val Ala Ser Ala Ala  Pro Ala Pro Gly Pro  Pro Arg Gln 
        995                 1000                 1005             


Leu Val  Glu Glu Leu Gln Ser  Arg Tyr Arg Gln Met  Glu Glu Arg 
    1010                 1015                 1020             


Ile Thr  Cys Pro Ile Cys Ile  Asp Ser His Ile Arg  Leu Val Phe 
    1025                 1030                 1035             


Gln Cys  Gly His Gly Ala Cys  Ala Pro Cys Gly Ser  Ala Leu Ser 
    1040                 1045                 1050             


Ala Cys  Pro Ile Cys Arg Gln  Pro Ile Arg Asp Arg  Ile Gln Ile 
    1055                 1060                 1065             


Phe Val  
    1070 


<210> 8381
<211> 318
<212> PRT
<213> Homo sapiens

<400> 8381
Met Cys Arg Thr Ala Leu Gly Val Thr Thr Leu Gln Asp Leu Gly Val 
1               5                   10                  15      


Cys Trp Arg Lys Glu His Asp Pro Ala Glu Met Leu Arg Val Gly Arg 
            20                  25                  30          


Ala Glu Leu Gly Gly Trp Lys Pro Ser Trp Glu Ala Ile Val Lys Glu 
        35                  40                  45              


Val Ala Ala Ala Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu 
    50                  55                  60                  


Asp Ile Leu Ala Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys 
65                  70                  75                  80  


Val Ala Lys Lys Lys Phe Ala Glu Asn Leu Lys Ala Gly Asp Glu Phe 
                85                  90                  95      


Val Glu Lys Thr Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser 
            100                 105                 110         


Val Val His Ser Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu 
        115                 120                 125             


Lys Val Lys Asn Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu 
    130                 135                 140                 


His Thr Ile Phe Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile 
145                 150                 155                 160 


Ala Asn Ala Thr Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe 
                165                 170                 175     


Asn Pro Val Pro Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met 
            180                 185                 190         


Thr Ser Gln Lys Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu 
        195                 200                 205             


Gly Lys His Pro Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn 
    210                 215                 220                 


Arg Leu Leu Val Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg 
225                 230                 235                 240 


Gly Asp Ala Ser Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala 
                245                 250                 255     


Gly Tyr Pro Met Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp 
            260                 265                 270         


Thr Thr Lys Phe Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn 
        275                 280                 285             


Pro Leu His Gln Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn 
    290                 295                 300                 


Lys Phe Gly Lys Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys 
305                 310                 315             


<210> 8382
<211> 347
<212> PRT
<213> Homo sapiens

<400> 8382
Met Lys Leu Thr Ser Glu Lys Leu Pro Lys Asn Pro Phe Tyr Ala Ser 
1               5                   10                  15      


Val Ser Gln Tyr Ala Ala Lys Asn Gln Lys Phe Phe Gln Trp Lys Lys 
            20                  25                  30          


Glu Lys Thr Asp Tyr Thr His Ala Asn Leu Val Asp Lys Ala Leu Gln 
        35                  40                  45              


Leu Leu Lys Glu Arg Ile Leu Lys Gly Asp Thr Leu Ala Tyr Phe Leu 
    50                  55                  60                  


Arg Gly Gln Leu Tyr Phe Glu Glu Gly Trp Tyr Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Gln Phe Glu Glu Ile Lys Glu Lys Asp His Gln Ala Thr Tyr Gln Leu 
                85                  90                  95      


Gly Val Met Tyr Tyr Asp Gly Leu Gly Thr Thr Leu Asp Ala Glu Lys 
            100                 105                 110         


Gly Val Asp Tyr Met Lys Lys Ile Leu Asp Ser Pro Cys Pro Lys Ala 
        115                 120                 125             


Arg His Leu Lys Phe Ala Ala Ala Tyr Asn Leu Gly Arg Ala Tyr Tyr 
    130                 135                 140                 


Glu Gly Lys Gly Val Lys Arg Ser Asn Glu Glu Ala Glu Arg Leu Trp 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Asn Gly Asn Pro Lys Ala Ser Val Lys Ala Gln 
                165                 170                 175     


Ser Met Leu Gly Leu Tyr Tyr Ser Thr Lys Glu Pro Lys Glu Leu Glu 
            180                 185                 190         


Lys Ala Phe Tyr Trp His Ser Glu Ala Cys Gly Asn Gly Asn Leu Glu 
        195                 200                 205             


Ser Gln Gly Ala Leu Gly Leu Met Tyr Leu Tyr Gly Gln Gly Ile Arg 
    210                 215                 220                 


Gln Asp Thr Glu Ala Ala Leu Gln Cys Leu Arg Glu Ala Ala Glu Arg 
225                 230                 235                 240 


Gly Asn Val Tyr Ala Gln Gly Asn Leu Val Glu Tyr Tyr Tyr Lys Met 
                245                 250                 255     


Lys Phe Phe Thr Lys Cys Val Ala Phe Ser Lys Arg Ile Ala Asp Tyr 
            260                 265                 270         


Asp Glu Val His Asp Ile Pro Met Ile Ala Gln Val Thr Asp Cys Leu 
        275                 280                 285             


Pro Glu Phe Ile Gly Arg Gly Met Ala Met Ala Ser Phe Tyr His Ala 
    290                 295                 300                 


Arg Cys Leu Gln Leu Gly Leu Gly Ile Thr Arg Asp Glu Thr Thr Ala 
305                 310                 315                 320 


Lys His Tyr Tyr Ser Lys Ala Cys Arg Leu Asn Pro Ala Leu Ala Asp 
                325                 330                 335     


Glu Leu His Ser Leu Leu Ile Arg Gln Arg Ile 
            340                 345         


<210> 8383
<211> 35
<212> PRT
<213> Homo sapiens

<400> 8383
Met Pro Gln Thr Phe Ser Gly Gly Arg Gly Phe Glu Leu Asp Ser Gly 
1               5                   10                  15      


Ser Asp Asp Met Asp Pro Gly Arg Pro Arg Pro Pro Arg Asp Pro Asp 
            20                  25                  30          


Glu Leu His 
        35  


<210> 8384
<211> 392
<212> PRT
<213> Homo sapiens

<400> 8384
Met Gly Thr Thr Cys Leu His Leu Gly Thr Leu Glu Gln Ser Leu Val 
1               5                   10                  15      


Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn 
            20                  25                  30          


Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser 
        35                  40                  45              


Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp 
    50                  55                  60                  


Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu 
65                  70                  75                  80  


Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu 
                85                  90                  95      


Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln 
            100                 105                 110         


Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala 
        115                 120                 125             


Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro 
    130                 135                 140                 


Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg 
145                 150                 155                 160 


Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys 
                165                 170                 175     


Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly 
            180                 185                 190         


Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile 
        195                 200                 205             


Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala 
    210                 215                 220                 


Met Ile Thr Arg Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr 
225                 230                 235                 240 


Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val 
                245                 250                 255     


Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe 
            260                 265                 270         


Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu 
        275                 280                 285             


Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser 
    290                 295                 300                 


Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro 
305                 310                 315                 320 


Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu 
                325                 330                 335     


Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn 
            340                 345                 350         


Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val 
        355                 360                 365             


Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val 
    370                 375                 380                 


Leu Arg Lys Leu Leu Thr Leu Asp 
385                 390         


<210> 8385
<211> 683
<212> PRT
<213> Homo sapiens

<400> 8385
Met Asn Thr Ser Ile Pro Tyr Gln Gln Asn Pro Tyr Asn Pro Arg Gly 
1               5                   10                  15      


Ser Ser Asn Val Ile Gln Cys Tyr Arg Cys Gly Asp Thr Cys Lys Gly 
            20                  25                  30          


Glu Val Val Arg Val His Asn Asn His Phe His Ile Arg Cys Phe Thr 
        35                  40                  45              


Cys Gln Val Cys Gly Cys Gly Leu Ala Gln Ser Gly Phe Phe Phe Lys 
    50                  55                  60                  


Asn Gln Glu Tyr Ile Cys Thr Gln Asp Tyr Gln Gln Leu Tyr Gly Thr 
65                  70                  75                  80  


Arg Cys Asp Ser Cys Arg Asp Phe Ile Thr Gly Glu Val Ile Ser Ala 
                85                  90                  95      


Leu Gly Arg Thr Tyr His Pro Lys Cys Phe Val Cys Ser Leu Cys Arg 
            100                 105                 110         


Lys Pro Phe Pro Ile Gly Asp Lys Val Thr Phe Ser Gly Lys Glu Cys 
        115                 120                 125             


Val Cys Gln Thr Cys Ser Gln Ser Met Ala Ser Ser Lys Pro Ile Lys 
    130                 135                 140                 


Ile Arg Gly Pro Ser His Cys Ala Gly Cys Lys Glu Glu Ile Lys His 
145                 150                 155                 160 


Gly Gln Ser Leu Leu Ala Leu Asp Lys Gln Trp His Val Ser Cys Phe 
                165                 170                 175     


Lys Cys Gln Thr Cys Ser Val Ile Leu Thr Gly Glu Tyr Ile Ser Lys 
            180                 185                 190         


Asp Gly Val Pro Tyr Cys Glu Ser Asp Tyr His Ala Gln Phe Gly Ile 
        195                 200                 205             


Lys Cys Glu Thr Cys Asp Arg Tyr Ile Ser Gly Arg Val Leu Glu Ala 
    210                 215                 220                 


Gly Gly Lys His Tyr His Pro Thr Cys Ala Arg Cys Val Arg Cys His 
225                 230                 235                 240 


Gln Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Thr Gly Ser Glu Val 
                245                 250                 255     


Trp His Pro Ile Cys Lys Gln Ala Ala Arg Ala Glu Lys Lys Leu Lys 
            260                 265                 270         


His Arg Arg Thr Ser Glu Thr Ser Ile Ser Pro Pro Gly Ser Ser Ile 
        275                 280                 285             


Gly Ser Pro Asn Arg Val Ile Cys Ala Lys Val Asp Asn Glu Ile Leu 
    290                 295                 300                 


Asn Tyr Lys Asp Leu Ala Ala Leu Pro Lys Val Lys Ser Ile Tyr Glu 
305                 310                 315                 320 


Val Gln Arg Pro Asp Leu Ile Ser Tyr Glu Pro His Ser Arg Tyr Met 
                325                 330                 335     


Ser Asp Glu Met Leu Glu Arg Cys Gly Tyr Gly Glu Ser Leu Gly Thr 
            340                 345                 350         


Leu Ser Pro Tyr Ser Gln Asp Ile Tyr Glu Asn Leu Asp Leu Arg Gln 
        355                 360                 365             


Arg Arg Ala Ser Ser Pro Gly Tyr Ile Asp Ser Pro Thr Tyr Ser Arg 
    370                 375                 380                 


Gln Gly Met Ser Pro Thr Phe Ser Arg Ser Pro His His Tyr Tyr Arg 
385                 390                 395                 400 


Ser Gly Pro Glu Ser Gly Arg Ser Ser Pro Tyr His Ser Gln Leu Asp 
                405                 410                 415     


Val Arg Ser Ser Thr Pro Thr Ser Tyr Gln Ala Pro Lys His Phe His 
            420                 425                 430         


Ile Pro Ala Gly Asp Ser Asn Ile Tyr Arg Lys Pro Pro Ile Tyr Lys 
        435                 440                 445             


Arg His Gly Asp Leu Ser Thr Ala Thr Lys Ser Lys Thr Ser Glu Asp 
    450                 455                 460                 


Ile Ser Gln Thr Ser Lys Tyr Ser Pro Ile Tyr Ser Pro Asp Pro Tyr 
465                 470                 475                 480 


Tyr Ala Ser Glu Ser Glu Tyr Trp Thr Tyr His Gly Ser Pro Lys Val 
                485                 490                 495     


Pro Arg Ala Arg Arg Phe Ser Ser Gly Gly Glu Glu Asp Asp Phe Asp 
            500                 505                 510         


Arg Ser Met His Lys Leu Gln Ser Gly Ile Gly Arg Leu Ile Leu Lys 
        515                 520                 525             


Glu Glu Met Lys Ala Arg Ser Ser Ser Tyr Ala Asp Pro Trp Thr Pro 
    530                 535                 540                 


Pro Arg Ser Ser Thr Ser Ser Arg Glu Ala Leu His Thr Ala Gly Tyr 
545                 550                 555                 560 


Glu Met Ser Leu Asn Gly Ser Pro Arg Ser His Tyr Leu Ala Asp Ser 
                565                 570                 575     


Asp Pro Leu Ile Ser Lys Ser Ala Ser Leu Pro Ala Tyr Arg Arg Asn 
            580                 585                 590         


Gly Leu His Arg Thr Pro Ser Ala Asp Leu Phe His Tyr Asp Ser Met 
        595                 600                 605             


Asn Ala Val Asn Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr Glu 
    610                 615                 620                 


Leu Leu Leu Val Thr Thr Arg Gly Arg Asn Arg Leu Pro Lys Asp Val 
625                 630                 635                 640 


Asp Arg Thr Arg Leu Glu Arg His Leu Ser Gln Glu Glu Phe Tyr Gln 
                645                 650                 655     


Val Phe Gly Met Thr Ile Ser Glu Phe Asp Arg Leu Ala Leu Trp Lys 
            660                 665                 670         


Arg Asn Glu Leu Lys Lys Gln Ala Arg Leu Phe 
        675                 680             


<210> 8386
<211> 32
<212> PRT
<213> Homo sapiens

<400> 8386
Met Asp Phe Phe Ser Ser His Leu Leu Ala Asp Ser Ser Ser Pro Ala 
1               5                   10                  15      


Thr Asn Ser Ser His Thr Asp Ala His Glu Ile Leu Val Ser Asp Phe 
            20                  25                  30          


<210> 8387
<211> 285
<212> PRT
<213> Homo sapiens

<400> 8387
Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro 
        35                  40                  45              


Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys 
    50                  55                  60                  


Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp 
65                  70                  75                  80  


Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val 
                85                  90                  95      


Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly 
            100                 105                 110         


Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu 
        115                 120                 125             


Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Gly Ser Thr Asn Tyr Gly Lys Ser 
            260                 265                 270         


Gln Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
        275                 280                 285 


<210> 8388
<211> 117
<212> PRT
<213> Homo sapiens

<400> 8388
Met Val Gln Arg Leu Thr Tyr Arg Arg Arg Leu Ser Tyr Asn Thr Ala 
1               5                   10                  15      


Ser Asn Lys Thr Arg Leu Ser Arg Thr Pro Gly Asn Arg Ile Val Tyr 
            20                  25                  30          


Leu Tyr Thr Lys Lys Val Gly Lys Ala Pro Lys Ser Ala Cys Gly Val 
        35                  40                  45              


Cys Pro Gly Arg Leu Arg Gly Val Arg Ala Val Arg Pro Lys Val Leu 
    50                  55                  60                  


Met Arg Leu Ser Lys Thr Lys Lys His Val Ser Arg Ala Tyr Gly Gly 
65                  70                  75                  80  


Ser Met Cys Ala Lys Cys Val Arg Asp Arg Ile Lys Arg Ala Phe Leu 
                85                  90                  95      


Ile Glu Glu Gln Lys Ile Val Val Lys Val Leu Lys Ala Gln Ala Gln 
            100                 105                 110         


Ser Gln Lys Ala Lys 
        115         


<210> 8389
<211> 2537
<212> PRT
<213> Homo sapiens

<400> 8389
Met Glu Asp Phe Arg Gly Ile Ala Glu Glu Ser Phe Pro Ser Phe Leu 
1               5                   10                  15      


Thr Asn Ser Leu Phe Gly Asn Ser Gly Ile Leu Glu Asn Val Thr Leu 
            20                  25                  30          


Ser Ser Asn Leu Gly Leu Pro Val Ala Val Ser Thr Leu Ala Arg Asp 
        35                  40                  45              


Arg Ser Ser Thr Asp Asn Arg Tyr Pro Asp Ile Gln Ala Ser Tyr Leu 
    50                  55                  60                  


Val Glu Gly Arg Phe Ser Val Pro Ser Gly Ser Ser Pro Gly Ser Gln 
65                  70                  75                  80  


Ser Asp Ala Glu Pro Arg Glu Arg Leu Gln Leu Ser Phe Gln Asp Asp 
                85                  90                  95      


Asp Ser Ile Ser Arg Lys Lys Ser Tyr Val Glu Ser Gln Arg Leu Ser 
            100                 105                 110         


Asn Ala Leu Ser Lys Gln Ser Ala Leu Gln Met Glu Thr Ala Gly Pro 
        115                 120                 125             


Glu Glu Glu Pro Ala Gly Ala Thr Glu Ser Leu Gln Gly Gln Asp Leu 
    130                 135                 140                 


Phe Asn Arg Ala Ser Pro Leu Glu Gln Ala Gln Asp Ser Pro Ile Asp 
145                 150                 155                 160 


Phe His Leu Gln Ser Trp Met Asn Asn Lys Glu Pro Lys Ile Val Val 
                165                 170                 175     


Leu Asp Ala Gly Lys His Phe Glu Asp Lys Thr Leu Lys Ser Asp Leu 
            180                 185                 190         


Ser His Thr Ser Leu Leu Glu Asn Glu Lys Leu Ile Leu Pro Thr Ser 
        195                 200                 205             


Leu Glu Asp Ser Ser Asp Asp Asp Ile Asp Asp Glu Met Phe Tyr Asp 
    210                 215                 220                 


Asp His Leu Glu Ala Tyr Phe Glu Gln Leu Ala Ile Pro Gly Met Ile 
225                 230                 235                 240 


Tyr Glu Asp Leu Glu Gly Pro Glu Pro Pro Glu Lys Gly Phe Lys Leu 
                245                 250                 255     


Pro Thr Asn Gly Leu Arg Gln Ala Asn Glu Asn Gly Ser Leu Asn Cys 
            260                 265                 270         


Lys Phe Gln Ser Glu Asn Asn Ser Ser Leu Ile Ser Leu Asp Ser His 
        275                 280                 285             


Ser Ser Glu Thr Thr His Lys Glu Ser Glu Glu Ser Gln Val Ile Cys 
    290                 295                 300                 


Leu Pro Gly Thr Ser Asn Ser Ile Gly Thr Gly Asp Ser Arg Arg Tyr 
305                 310                 315                 320 


Thr Asp Gly Met Leu Pro Phe Ser Ser Gly Thr Trp Gly Thr Glu Lys 
                325                 330                 335     


Glu Ile Glu Asn Leu Lys Gly Ile Val Pro Asp Leu Asn Ser Glu Cys 
            340                 345                 350         


Ala Ser Lys Asp Val Leu Val Lys Thr Leu Arg Ala Ile Asp Val Lys 
        355                 360                 365             


Leu Asn Ser Asp Asn Phe His Asp Ala Asn Ala Asn Arg Gly Gly Phe 
    370                 375                 380                 


Asp Leu Thr Asp Pro Val Lys Gln Gly Ala Glu Cys Pro His Gln Asn 
385                 390                 395                 400 


Lys Thr Val Leu His Met Asp Gly Cys Leu Asp Thr Glu Thr Pro Thr 
                405                 410                 415     


Val Ser Ile Gln Glu Asn Val Asp Val Ala Ser Leu Lys Pro Ile Ser 
            420                 425                 430         


Asp Ser Gly Ile Asn Phe Thr Asp Ala Ile Trp Ser Pro Thr Cys Glu 
        435                 440                 445             


Arg Arg Thr Cys Glu Cys His Glu Ser Ile Glu Lys Asn Lys Asp Lys 
    450                 455                 460                 


Thr Asp Leu Pro Gln Ser Val Val Tyr Gln Asn Glu Glu Gly Arg Trp 
465                 470                 475                 480 


Val Thr Asp Leu Ala Tyr Tyr Thr Ser Phe Asn Ser Lys Gln Asn Leu 
                485                 490                 495     


Asn Val Ser Leu Ser Asp Glu Met Asn Glu Asp Phe Arg Ser Gly Ser 
            500                 505                 510         


Glu Ala Phe Asp Leu Ile Ala Gln Asp Glu Glu Glu Phe Asn Lys Glu 
        515                 520                 525             


His Gln Phe Ile Gln Glu Glu Asn Ile Asp Ala His Asn Thr Ser Val 
    530                 535                 540                 


Ala Leu Gly Asp Thr Ser Trp Gly Ala Thr Ile Asn Tyr Ser Leu Leu 
545                 550                 555                 560 


Arg Lys Ser Arg Ser Thr Ser Asp Leu Asp Lys Asp Asp Ala Ser Tyr 
                565                 570                 575     


Leu Arg Leu Ser Leu Gly Glu Phe Phe Ala Gln Arg Ser Glu Ala Leu 
            580                 585                 590         


Gly Cys Leu Gly Gly Gly Asn Asn Val Lys Arg Pro Ser Phe Gly Tyr 
        595                 600                 605             


Phe Ile Arg Ser Pro Glu Lys Arg Glu Pro Ile Ala Leu Ile Arg Lys 
    610                 615                 620                 


Ser Asp Val Ser Arg Gly Asn Leu Glu Lys Glu Met Ala His Leu Asn 
625                 630                 635                 640 


His Asp Leu Tyr Ser Gly Asp Leu Asn Glu Gln Ser Gln Ala Gln Leu 
                645                 650                 655     


Ser Glu Gly Ser Ile Thr Leu Gln Val Glu Ala Val Glu Ser Thr Ser 
            660                 665                 670         


Gln Val Asp Glu Asn Asp Val Thr Leu Thr Ala Asp Lys Gly Lys Thr 
        675                 680                 685             


Glu Asp Thr Phe Phe Met Ser Asn Lys Pro Gln Arg Tyr Lys Asp Lys 
    690                 695                 700                 


Leu Pro Asp Ser Gly Asp Ser Met Leu Arg Ile Ser Thr Ile Ala Ser 
705                 710                 715                 720 


Ala Ile Ala Glu Ala Ser Val Asn Thr Asp Pro Ser Gln Leu Ala Ala 
                725                 730                 735     


Met Ile Lys Ala Leu Ser Asn Lys Thr Arg Asp Lys Thr Phe Gln Glu 
            740                 745                 750         


Asp Glu Lys Gln Lys Asp Tyr Ser His Val Arg His Phe Leu Pro Asn 
        755                 760                 765             


Asp Leu Glu Lys Ser Asn Gly Ser Asn Ala Leu Asp Met Glu Lys Tyr 
    770                 775                 780                 


Leu Lys Lys Thr Glu Val Ser Arg Tyr Glu Ser Ala Leu Glu Asn Phe 
785                 790                 795                 800 


Ser Arg Ala Ser Met Ser Asp Thr Trp Asp Leu Ser Leu Pro Lys Glu 
                805                 810                 815     


Gln Thr Thr Gln Asp Ile His Pro Val Asp Leu Ser Ala Thr Ser Val 
            820                 825                 830         


Ser Val Arg Ala Pro Glu Glu Asn Thr Ala Ala Ile Val Tyr Val Glu 
        835                 840                 845             


Asn Gly Glu Ser Glu Asn Gln Glu Ser Phe Arg Thr Ile Asn Ser Ser 
    850                 855                 860                 


Asn Ser Val Thr Asn Arg Glu Asn Asn Ser Ala Val Val Asp Val Lys 
865                 870                 875                 880 


Thr Cys Ser Ile Asp Asn Lys Leu Gln Asp Val Gly Asn Asp Glu Lys 
                885                 890                 895     


Ala Thr Ser Ile Ser Thr Pro Ser Asp Ser Tyr Ser Ser Val Arg Asn 
            900                 905                 910         


Pro Arg Ile Thr Ser Leu Cys Leu Leu Lys Asp Cys Glu Glu Ile Arg 
        915                 920                 925             


Asp Asn Arg Glu Asn Gln Arg Gln Asn Glu Cys Val Ser Glu Ile Ser 
    930                 935                 940                 


Asn Ser Glu Lys His Val Thr Phe Glu Asn His Arg Ile Val Ser Pro 
945                 950                 955                 960 


Lys Asn Ser Asp Leu Lys Asn Thr Ser Pro Glu His Gly Gly Arg Gly 
                965                 970                 975     


Ser Glu Asp Glu Gln Glu Ser Phe Arg Pro Ser Thr Ser Pro Leu Ser 
            980                 985                 990         


His Ser Ser Pro Ser Glu Ile Ser  Gly Thr Ser Ser Ser  Gly Cys Ala 
        995                 1000                 1005             


Leu Glu  Ser Phe Gly Ser Ala  Ala Gln Gln Gln Gln  Pro Pro Cys 
    1010                 1015                 1020             


Glu Gln  Glu Leu Ser Pro Leu  Val Cys Ser Pro Ala  Gly Val Ser 
    1025                 1030                 1035             


Arg Leu  Thr Tyr Val Ser Glu  Pro Glu Ser Ser Tyr  Pro Thr Thr 
    1040                 1045                 1050             


Ala Thr  Asp Asp Ala Leu Glu  Asp Arg Lys Ser Asp  Ile Thr Ser 
    1055                 1060                 1065             


Glu Leu  Ser Thr Thr Ile Ile  Gln Gly Ser Pro Ala  Ala Leu Glu 
    1070                 1075                 1080             


Glu Arg  Ala Met Glu Lys Leu  Arg Glu Lys Val Pro  Phe Gln Asn 
    1085                 1090                 1095             


Arg Gly  Lys Gly Thr Leu Ser  Ser Ile Ile Gln Asn  Asn Ser Asp 
    1100                 1105                 1110             


Thr Arg  Lys Ala Thr Glu Thr  Thr Ser Leu Ser Ser  Lys Pro Glu 
    1115                 1120                 1125             


Tyr Val  Lys Pro Asp Phe Arg  Trp Ser Lys Asp Pro  Ser Ser Lys 
    1130                 1135                 1140             


Ser Gly  Asn Leu Leu Glu Thr  Ser Glu Val Gly Trp  Thr Ser Asn 
    1145                 1150                 1155             


Pro Glu  Glu Leu Asp Pro Ile  Arg Leu Ala Leu Leu  Gly Lys Ser 
    1160                 1165                 1170             


Gly Leu  Ser Cys Gln Val Gly  Ser Ala Thr Ser His  Pro Val Ser 
    1175                 1180                 1185             


Cys Gln  Glu Pro Ile Asp Glu  Asp Gln Arg Ile Ser  Pro Lys Asp 
    1190                 1195                 1200             


Lys Ser  Thr Ala Gly Arg Glu  Phe Ser Gly Gln Val  Ser His Gln 
    1205                 1210                 1215             


Thr Thr  Ser Glu Asn Gln Cys  Thr Pro Ile Pro Ser  Ser Thr Val 
    1220                 1225                 1230             


His Ser  Ser Val Ala Asp Met  Gln Asn Met Pro Ala  Ala Val His 
    1235                 1240                 1245             


Ala Leu  Leu Thr Gln Pro Ser  Leu Ser Ala Ala Pro  Phe Ala Gln 
    1250                 1255                 1260             


Arg Tyr  Leu Gly Thr Leu Pro  Ser Thr Gly Ser Thr  Thr Leu Pro 
    1265                 1270                 1275             


Gln Cys  His Ala Gly Asn Ala  Thr Val Cys Gly Phe  Ser Gly Gly 
    1280                 1285                 1290             


Leu Pro  Tyr Pro Ala Val Ala  Gly Glu Pro Val Gln  Asn Ser Val 
    1295                 1300                 1305             


Ala Val  Gly Ile Cys Leu Gly  Ser Asn Ile Gly Ser  Gly Trp Met 
    1310                 1315                 1320             


Gly Thr  Ser Ser Leu Cys Asn  Pro Tyr Ser Asn Thr  Leu Asn Gln 
    1325                 1330                 1335             


Asn Leu  Leu Ser Thr Thr Lys  Pro Phe Pro Val Pro  Ser Val Gly 
    1340                 1345                 1350             


Thr Asn  Cys Gly Ile Glu Pro  Trp Asp Ser Gly Val  Thr Ser Gly 
    1355                 1360                 1365             


Leu Gly  Ser Val Arg Val Pro  Glu Glu Leu Lys Leu  Pro His Ala 
    1370                 1375                 1380             


Cys Cys  Val Gly Ile Ala Ser  Gln Thr Leu Leu Ser  Val Leu Asn 
    1385                 1390                 1395             


Pro Thr  Asp Arg Trp Leu Gln  Val Ser Ile Gly Val  Leu Ser Ile 
    1400                 1405                 1410             


Ser Val  Asn Gly Glu Lys Val  Asp Leu Ser Thr Tyr  Arg Cys Leu 
    1415                 1420                 1425             


Val Phe  Lys Asn Lys Ala Ile  Ile Arg Pro His Ala  Thr Glu Glu 
    1430                 1435                 1440             


Ile Lys  Val Leu Phe Ile Pro  Ser Ser Pro Gly Val  Phe Arg Cys 
    1445                 1450                 1455             


Thr Phe  Ser Val Ala Ser Trp  Pro Cys Ser Thr Asp  Ala Glu Thr 
    1460                 1465                 1470             


Ile Val  Gln Ala Glu Ala Leu  Ala Ser Thr Val Thr  Leu Thr Ala 
    1475                 1480                 1485             


Ile Ala  Glu Ser Pro Val Ile  Glu Val Glu Thr Glu  Lys Lys Asp 
    1490                 1495                 1500             


Val Leu  Asp Phe Gly Asp Leu  Thr Tyr Gly Gly Trp  Lys Ala Leu 
    1505                 1510                 1515             


Pro Leu  Lys Leu Ile Asn Arg  Thr His Ala Thr Val  Pro Ile Arg 
    1520                 1525                 1530             


Leu Ile  Ile Asn Ala Asn Ala  Val Ala Trp Arg Cys  Phe Thr Phe 
    1535                 1540                 1545             


Ser Lys  Glu Ser Val Arg Ala  Pro Val Glu Val Ala  Pro Cys Ala 
    1550                 1555                 1560             


Asp Val  Val Thr Arg Leu Ala  Gly Pro Ser Val Val  Asn His Met 
    1565                 1570                 1575             


Met Pro  Ala Ser Tyr Asp Gly  Gln Asp Pro Glu Phe  Leu Met Ile 
    1580                 1585                 1590             


Trp Val  Leu Phe His Ser Pro  Lys Lys Gln Ile Ser  Ser Ser Asp 
    1595                 1600                 1605             


Ile Leu  Asp Ser Ala Glu Glu  Phe Ser Ala Lys Val  Asp Ile Glu 
    1610                 1615                 1620             


Val Asp  Ser Pro Asn Pro Thr  Pro Val Leu Arg Ser  Val Ser Leu 
    1625                 1630                 1635             


Arg Ala  Arg Ala Gly Ile Ala  Arg Ile His Ala Pro  Arg Asp Leu 
    1640                 1645                 1650             


Gln Thr  Met His Phe Leu Ala  Lys Val Ala Ser Ser  Arg Lys Gln 
    1655                 1660                 1665             


His Leu  Pro Leu Lys Asn Ala  Gly Asn Ile Glu Val  Tyr Leu Asp 
    1670                 1675                 1680             


Ile Lys  Val Pro Glu Gln Gly  Ser His Phe Ser Val  Asp Pro Lys 
    1685                 1690                 1695             


Asn Leu  Leu Leu Lys Pro Gly  Glu Glu His Glu Val  Ile Val Ser 
    1700                 1705                 1710             


Phe Thr  Pro Lys Asp Pro Glu  Ala Cys Glu Glu Arg  Ile Leu Lys 
    1715                 1720                 1725             


Ile Phe  Val Gln Pro Phe Gly  Pro Gln Tyr Glu Val  Val Leu Lys 
    1730                 1735                 1740             


Gly Glu  Val Ile Ser Ser Gly  Ser Lys Pro Leu Ser  Pro Gly Pro 
    1745                 1750                 1755             


Cys Leu  Asp Ile Pro Ser Ile  Leu Ser Asn Lys Gln  Phe Leu Ala 
    1760                 1765                 1770             


Trp Gly  Gly Val Pro Leu Gly  Arg Thr Gln Leu Gln  Lys Leu Ala 
    1775                 1780                 1785             


Leu Arg  Asn Asn Ser Ala Ser  Thr Thr Gln His Leu  Arg Leu Leu 
    1790                 1795                 1800             


Ile Arg  Gly Gln Asp Gln Asp  Cys Phe Gln Leu Gln  Asn Thr Phe 
    1805                 1810                 1815             


Gly Ser  Glu Gln Arg Leu Thr  Ser Asn Cys Glu Ile  Arg Ile His 
    1820                 1825                 1830             


Pro Lys  Glu Asp Ile Phe Ile  Ser Val Leu Phe Ala  Pro Thr Arg 
    1835                 1840                 1845             


Leu Ser  Cys Met Leu Ala Arg  Leu Glu Ile Lys Gln  Leu Gly Asn 
    1850                 1855                 1860             


Arg Ser  Gln Pro Gly Ile Lys  Phe Thr Ile Pro Leu  Ser Gly Tyr 
    1865                 1870                 1875             


Gly Gly  Thr Ser Asn Leu Ile  Leu Glu Gly Val Lys  Lys Leu Ser 
    1880                 1885                 1890             


Asp Ser  Tyr Met Val Thr Val  Asn Gly Leu Val Pro  Gly Lys Glu 
    1895                 1900                 1905             


Ser Lys  Ile Val Phe Ser Val  Arg Asn Thr Gly Ser  Arg Ala Ala 
    1910                 1915                 1920             


Phe Val  Lys Ala Val Gly Phe  Lys Asp Ser Gln Lys  Lys Val Leu 
    1925                 1930                 1935             


Leu Asp  Pro Lys Val Leu Arg  Ile Phe Pro Asp Lys  Phe Val Leu 
    1940                 1945                 1950             


Lys Glu  Arg Thr Gln Glu Asn  Val Thr Leu Ile Tyr  Asn Pro Ser 
    1955                 1960                 1965             


Asp Arg  Gly Ile Asn Asn Lys  Thr Ala Thr Glu Leu  Ser Thr Val 
    1970                 1975                 1980             


Tyr Leu  Phe Gly Gly Asp Glu  Ile Ser Arg Gln Gln  Tyr Arg Arg 
    1985                 1990                 1995             


Ala Leu  Leu His Lys Pro Glu  Met Ile Lys Gln Ile  Leu Pro Glu 
    2000                 2005                 2010             


His Ser  Val Leu Gln Asn Ile  Asn Phe Val Glu Ala  Phe Gln Asp 
    2015                 2020                 2025             


Glu Leu  Leu Val Thr Glu Val  Tyr Asp Leu Pro Gln  Arg Pro Asn 
    2030                 2035                 2040             


Asp Val  Gln Leu Phe Tyr Gly  Ser Met Cys Lys Ile  Ile Leu Ser 
    2045                 2050                 2055             


Val Ile  Gly Glu Phe Arg Asp  Cys Ile Ser Ser Arg  Glu Phe Leu 
    2060                 2065                 2070             


Gln Pro  Ser Ser Lys Ala Ser  Leu Glu Ser Thr Ser  Asp Leu Gly 
    2075                 2080                 2085             


Ala Ser  Gly Lys His Gly Gly  Asn Val Ser Leu Asp  Val Leu Pro 
    2090                 2095                 2100             


Val Lys  Gly Pro Gln Gly Ser  Pro Leu Leu Ser Arg  Ala Ala Arg 
    2105                 2110                 2115             


Pro Pro  Leu Asp Gln Leu Ala  Ser Glu Glu Pro Trp  Thr Val Leu 
    2120                 2125                 2130             


Pro Glu  His Leu Ile Leu Val  Ala Pro Ser Pro Cys  Asp Met Ala 
    2135                 2140                 2145             


Lys Thr  Gly Arg Phe Gln Ile  Val Asn Asn Ser Val  Arg Leu Leu 
    2150                 2155                 2160             


Arg Phe  Glu Leu Cys Trp Pro  Ala His Cys Leu Thr  Val Thr Pro 
    2165                 2170                 2175             


Gln His  Gly Cys Val Ala Pro  Glu Ser Lys Leu Gln  Ile Leu Val 
    2180                 2185                 2190             


Ser Pro  Asn Ser Ser Leu Ser  Thr Lys Gln Ser Met  Phe Pro Trp 
    2195                 2200                 2205             


Ser Gly  Leu Ile Tyr Ile His  Cys Asp Asp Gly Gln  Lys Lys Ile 
    2210                 2215                 2220             


Val Lys  Val Gln Ile Arg Glu  Asp Leu Thr Gln Val  Glu Leu Leu 
    2225                 2230                 2235             


Thr Arg  Leu Thr Ser Lys Pro  Phe Gly Ile Leu Ser  Pro Val Ser 
    2240                 2245                 2250             


Glu Pro  Ser Val Ser His Leu  Val Lys Pro Met Thr  Lys Pro Pro 
    2255                 2260                 2265             


Ser Thr  Lys Val Glu Ile Arg  Asn Lys Ser Ile Thr  Phe Pro Thr 
    2270                 2275                 2280             


Thr Glu  Pro Gly Glu Thr Ser  Glu Ser Cys Leu Glu  Leu Glu Asn 
    2285                 2290                 2295             


His Gly  Thr Thr Asp Val Lys  Trp His Leu Ser Ser  Leu Ala Pro 
    2300                 2305                 2310             


Pro Tyr  Val Lys Gly Val Asp  Glu Ser Gly Asp Val  Phe Arg Ala 
    2315                 2320                 2325             


Thr Tyr  Ala Ala Phe Arg Cys  Ser Pro Ile Ser Gly  Leu Leu Glu 
    2330                 2335                 2340             


Ser His  Gly Ile Gln Lys Val  Ser Ile Thr Phe Leu  Pro Arg Gly 
    2345                 2350                 2355             


Arg Gly  Asp Tyr Ala Gln Phe  Trp Asp Val Glu Cys  His Pro Leu 
    2360                 2365                 2370             


Lys Glu  Pro His Met Lys His  Thr Leu Arg Phe Gln  Leu Ser Gly 
    2375                 2380                 2385             


Gln Ser  Ile Glu Ala Glu Asn  Glu Pro Glu Asn Ala  Cys Leu Ser 
    2390                 2395                 2400             


Thr Asp  Ser Leu Ile Lys Ile  Asp His Leu Val Lys  Pro Arg Arg 
    2405                 2410                 2415             


Gln Ala  Val Ser Glu Ala Ser  Ala Arg Ile Pro Glu  Gln Leu Asp 
    2420                 2425                 2430             


Val Thr  Ala Arg Gly Val Tyr  Ala Pro Glu Asp Val  Tyr Arg Phe 
    2435                 2440                 2445             


Arg Pro  Thr Ser Val Gly Glu  Ser Arg Thr Leu Lys  Val Asn Leu 
    2450                 2455                 2460             


Arg Asn  Asn Ser Phe Ile Thr  His Ser Leu Lys Phe  Leu Ser Pro 
    2465                 2470                 2475             


Arg Glu  Pro Phe Tyr Val Lys  His Ser Lys Tyr Ser  Leu Arg Ala 
    2480                 2485                 2490             


Gln His  Tyr Ile Asn Met Pro  Val Gln Phe Lys Pro  Lys Ser Ala 
    2495                 2500                 2505             


Gly Lys  Phe Glu Ala Leu Leu  Val Ile Gln Thr Asp  Glu Gly Lys 
    2510                 2515                 2520             


Ser Ile  Ala Ile Arg Leu Ile  Gly Glu Ala Leu Gly  Lys Asn 
    2525                 2530                 2535         


<210> 8390
<211> 29
<212> PRT
<213> Homo sapiens

<400> 8390
Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp 
            20                  25                  


<210> 8391
<211> 21
<212> PRT
<213> Homo sapiens

<400> 8391
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe 
            20      


<210> 8392
<211> 86
<212> PRT
<213> Homo sapiens

<400> 8392
Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln 
                85      


<210> 8393
<211> 660
<212> PRT
<213> Homo sapiens

<400> 8393
Met Val Thr Ser Leu Asn Glu Asp Asn Glu Ser Val Thr Val Glu Trp 
1               5                   10                  15      


Ile Glu Asn Gly Asp Thr Lys Gly Lys Glu Ile Asp Leu Glu Ser Ile 
            20                  25                  30          


Phe Ser Leu Asn Pro Asp Leu Val Pro Asp Glu Glu Ile Glu Pro Ser 
        35                  40                  45              


Pro Glu Thr Pro Pro Pro Pro Ala Ser Ser Ala Lys Val Asn Lys Ile 
    50                  55                  60                  


Val Lys Asn Arg Arg Thr Val Ala Ser Ile Lys Asn Asp Pro Pro Ser 
65                  70                  75                  80  


Arg Asp Asn Arg Val Val Gly Ser Ala Arg Ala Arg Pro Ser Gln Phe 
                85                  90                  95      


Pro Glu Gln Ser Ser Ser Ala Gln Gln Asn Ala Arg Arg Lys Ser Asn 
            100                 105                 110         


Cys Val Lys Glu Val Glu Lys Leu Gln Glu Lys Arg Glu Lys Arg Arg 
        115                 120                 125             


Leu Gln Gln Gln Glu Leu Arg Glu Lys Arg Ala Gln Asp Val Asp Ala 
    130                 135                 140                 


Thr Asn Pro Asn Tyr Glu Ile Met Cys Met Ile Arg Asp Phe Arg Gly 
145                 150                 155                 160 


Ser Leu Asp Tyr Arg Pro Leu Thr Thr Ala Asp Pro Ile Asp Glu His 
                165                 170                 175     


Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Lys Glu Thr 
            180                 185                 190         


Gln Met Lys Asp Leu Asp Val Ile Thr Ile Pro Ser Lys Asp Val Val 
        195                 200                 205             


Met Val His Glu Pro Lys Gln Lys Val Asp Leu Thr Arg Tyr Leu Glu 
    210                 215                 220                 


Asn Gln Thr Phe Arg Phe Asp Tyr Ala Phe Asp Asp Ser Ala Pro Asn 
225                 230                 235                 240 


Glu Met Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Glu Thr Ile Phe 
                245                 250                 255     


Glu Arg Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser Gly 
            260                 265                 270         


Lys Thr His Thr Met Gly Gly Asp Phe Ser Gly Lys Asn Gln Asp Cys 
        275                 280                 285             


Ser Lys Gly Ile Tyr Ala Leu Ala Ala Arg Asp Val Phe Leu Met Leu 
    290                 295                 300                 


Lys Lys Pro Asn Tyr Lys Lys Leu Glu Leu Gln Val Tyr Ala Thr Phe 
305                 310                 315                 320 


Phe Glu Ile Tyr Ser Gly Lys Val Phe Asp Leu Leu Asn Arg Lys Thr 
                325                 330                 335     


Lys Leu Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val Gly 
            340                 345                 350         


Leu Gln Glu Arg Glu Val Lys Cys Val Glu Asp Val Leu Lys Leu Ile 
        355                 360                 365             


Asp Ile Gly Asn Ser Cys Arg Thr Ser Gly Gln Thr Ser Ala Asn Ala 
    370                 375                 380                 


His Ser Ser Arg Ser His Ala Val Phe Gln Ile Ile Leu Arg Arg Lys 
385                 390                 395                 400 


Gly Lys Leu His Gly Lys Phe Ser Leu Ile Asp Leu Ala Gly Asn Glu 
                405                 410                 415     


Arg Gly Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Leu Glu Gly 
            420                 425                 430         


Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg Ala 
        435                 440                 445             


Leu Gly Arg Asn Lys Pro His Thr Pro Phe Arg Ala Ser Lys Leu Thr 
    450                 455                 460                 


Gln Val Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys Met 
465                 470                 475                 480 


Ile Ala Thr Ile Ser Pro Gly Met Ala Ser Cys Glu Asn Thr Leu Asn 
                485                 490                 495     


Thr Leu Arg Tyr Ala Asn Arg Val Lys Glu Leu Thr Val Asp Pro Thr 
            500                 505                 510         


Ala Ala Gly Asp Val Arg Pro Ile Met His His Pro Pro Asn Gln Ile 
        515                 520                 525             


Asp Asp Leu Glu Thr Gln Trp Gly Val Gly Ser Ser Pro Gln Arg Asp 
    530                 535                 540                 


Asp Leu Lys Leu Leu Cys Glu Gln Asn Glu Glu Glu Val Ser Pro Gln 
545                 550                 555                 560 


Leu Phe Thr Phe His Glu Ala Val Ser Gln Met Val Glu Met Glu Glu 
                565                 570                 575     


Gln Val Val Glu Asp His Arg Ala Val Phe Gln Glu Ser Ile Arg Trp 
            580                 585                 590         


Leu Glu Asp Glu Lys Ala Leu Leu Glu Met Thr Glu Glu Val Asp Tyr 
        595                 600                 605             


Asp Val Asp Ser Tyr Ala Thr Gln Leu Glu Ala Ile Leu Glu Gln Lys 
    610                 615                 620                 


Ile Asp Ile Leu Thr Glu Leu Arg Asp Lys Val Lys Ser Phe Arg Ala 
625                 630                 635                 640 


Ala Leu Gln Glu Glu Glu Gln Ala Ser Lys Gln Ile Asn Pro Lys Arg 
                645                 650                 655     


Pro Arg Ala Leu 
            660 


<210> 8394
<211> 68
<212> PRT
<213> Homo sapiens

<400> 8394
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp 
65              


<210> 8395
<211> 97
<212> PRT
<213> Homo sapiens

<400> 8395
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr 
    


<210> 8396
<211> 102
<212> PRT
<213> Homo sapiens

<400> 8396
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly 
            100         


<210> 8397
<211> 198
<212> PRT
<213> Homo sapiens

<400> 8397
Met Gly Thr Thr Cys Leu His Leu Gly Thr Leu Glu Gln Ser Leu Val 
1               5                   10                  15      


Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn 
            20                  25                  30          


Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser 
        35                  40                  45              


Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp 
    50                  55                  60                  


Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu 
65                  70                  75                  80  


Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu 
                85                  90                  95      


Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln 
            100                 105                 110         


Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala 
        115                 120                 125             


Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro 
    130                 135                 140                 


Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg 
145                 150                 155                 160 


Tyr Arg Asp Ile Leu Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn 
                165                 170                 175     


Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu 
            180                 185                 190         


Leu Leu Arg Tyr Cys Ala 
        195             


<210> 8398
<211> 127
<212> PRT
<213> Homo sapiens

<400> 8398
Met Arg Pro Leu Asp Ile Val Glu Leu Ala Glu Pro Glu Glu Val Glu 
1               5                   10                  15      


Val Leu Glu Pro Glu Glu Asp Phe Glu Gln Phe Leu Leu Pro Val Ile 
            20                  25                  30          


Asn Glu Met Arg Glu Asp Ile Ala Ser Leu Thr Arg Glu His Gly Arg 
        35                  40                  45              


Ala Tyr Leu Arg Asn Arg Ser Lys Leu Trp Glu Met Asp Asn Met Leu 
    50                  55                  60                  


Ile Gln Ile Lys Thr Gln Val Glu Ala Ser Glu Glu Ser Ala Leu Asn 
65                  70                  75                  80  


His Leu Gln Asn Pro Gly Asp Ala Ala Glu Gly Arg Ala Ala Lys Arg 
                85                  90                  95      


Cys Glu Lys Ala Glu Glu Lys Ala Lys Glu Ile Ala Lys Met Ala Glu 
            100                 105                 110         


Met Leu Val Glu Leu Val Arg Arg Ile Glu Lys Ser Glu Ser Ser 
        115                 120                 125         


<210> 8399
<211> 141
<212> PRT
<213> Homo sapiens

<400> 8399
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser 
    130                 135                 140     


<210> 8400
<211> 44
<212> PRT
<213> Homo sapiens

<400> 8400
Met Leu Leu Leu Asp Cys Asn Pro Glu Val Asp Gly Leu Lys His Leu 
1               5                   10                  15      


Leu Glu Thr Gly Ala Ser Val Asn Ala Pro Pro Asp Pro Cys Lys Gln 
            20                  25                  30          


Ser Pro Val His Leu Ala Ala Gly Ser Gly Leu Ala 
        35                  40                  


<210> 8401
<211> 132
<212> PRT
<213> Homo sapiens

<400> 8401
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg 
    130         


<210> 8402
<211> 323
<212> PRT
<213> Homo sapiens

<400> 8402
Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala 
        195                 200                 205             


Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu 
    210                 215                 220                 


Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr 
225                 230                 235                 240 


Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg 
                245                 250                 255     


Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp 
            260                 265                 270         


Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr 
        275                 280                 285             


Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala 
    290                 295                 300                 


Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Gln 
            


<210> 8403
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8403
Met Ala Gln Thr Asp Lys Pro Thr Cys Ile Pro Pro Glu Leu Pro Lys 
1               5                   10                  15      


Met Leu Lys Glu Phe Ala Lys Ala Ala Ile Arg Ala Gln Pro Gln Asp 
            20                  25                  30          


Leu Ile Gln Trp Gly Ala Asp Tyr Phe Glu Ala Leu Ser Arg Gly Glu 
        35                  40                  45              


Thr Pro Pro Val Arg Glu Arg Ser Glu Arg Val Ala Leu Cys Asn Trp 
    50                  55                  60                  


Ala Glu Leu Thr Pro Glu Leu Leu Lys Ile Leu His Ser Gln Val Ala 
65                  70                  75                  80  


Gly Arg Leu Ile Ile Arg Ala Glu Glu Leu Ala Gln Met Trp Lys Val 
                85                  90                  95      


Val Asn Leu Pro Thr Asp Leu 
            100             


<210> 8404
<211> 179
<212> PRT
<213> Homo sapiens

<400> 8404
Met Glu Asp Gly Thr Pro Lys His Ile Ile Gln Met Thr Gly Phe Lys 
1               5                   10                  15      


Met Glu Glu Lys Glu Ala Leu Val Lys Leu Leu Leu Lys Leu Asp Cys 
            20                  25                  30          


Thr Phe Ile Lys Ser Glu Lys Tyr Lys Asn Cys Thr His Leu Ile Ala 
        35                  40                  45              


Glu Arg Leu Cys Lys Ser Glu Lys Phe Leu Ala Ala Cys Ala Ala Gly 
    50                  55                  60                  


Lys Trp Ile Leu Thr Lys Asp Tyr Ile Ile His Ser Ala Lys Ser Gly 
65                  70                  75                  80  


Arg Trp Leu Asp Glu Thr Thr Tyr Glu Trp Gly Tyr Lys Ile Glu Lys 
                85                  90                  95      


Asp Ser Arg Tyr Ser Pro Gln Met Gln Ser Ala Pro Lys Arg Trp Arg 
            100                 105                 110         


Glu Glu Leu Lys Arg Thr Gly Ala Pro Gly Ala Phe His Arg Trp Lys 
        115                 120                 125             


Val Val Leu Leu Val Arg Thr Asp Lys Arg Ser Asp Ser Leu Ile Arg 
    130                 135                 140                 


Lys Lys Phe Arg Met Met Lys Ile Pro Lys Pro Ile Leu Phe Gly Leu 
145                 150                 155                 160 


Asn Ile Ala Met Lys Lys Gln Thr Lys Ile Ser Gly Lys Met Gln Asp 
                165                 170                 175     


Phe Leu Lys 
            


<210> 8405
<211> 150
<212> PRT
<213> Homo sapiens

<400> 8405
Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys Met His Leu Glu Lys Leu Glu Glu 
                85                  90                  95      


Gln Leu Ser Arg Ser His Gly Gln Glu Val Asn Glu Leu Lys Thr Lys 
            100                 105                 110         


Ile Glu Lys Leu Lys Val Glu Leu Asp Glu Ala Arg Leu Ser Glu Lys 
        115                 120                 125             


Gln Leu Lys His Gln Val Asp His Gln Lys Glu Leu Leu Ser Cys Lys 
    130                 135                 140                 


Ser Glu Glu Leu Arg Val 
145                 150 


<210> 8406
<211> 245
<212> PRT
<213> Homo sapiens

<400> 8406
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 
            180                 185                 190         


Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 
        195                 200                 205             


Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 
    210                 215                 220                 


Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 
225                 230                 235                 240 


Asp Thr Trp Asp Glu 
                245 


<210> 8407
<211> 59
<212> PRT
<213> Homo sapiens

<400> 8407
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn 
    50                  55                  


<210> 8408
<211> 198
<212> PRT
<213> Homo sapiens

<400> 8408
Met Gly Thr Thr Cys Leu His Leu Gly Thr Leu Glu Gln Ser Leu Val 
1               5                   10                  15      


Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn 
            20                  25                  30          


Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser 
        35                  40                  45              


Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp 
    50                  55                  60                  


Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu 
65                  70                  75                  80  


Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu 
                85                  90                  95      


Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln 
            100                 105                 110         


Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala 
        115                 120                 125             


Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro 
    130                 135                 140                 


Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg 
145                 150                 155                 160 


Tyr Arg Asp Ile Leu Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn 
                165                 170                 175     


Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu 
            180                 185                 190         


Leu Leu Arg Tyr Cys Ala 
        195             


<210> 8409
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8409
Met Ala Ser Ala Ser Ala Arg Gly Asn Gln Asp Lys Asp Ala His Phe 
1               5                   10                  15      


Pro Pro Pro Ser Lys Gln Ser Leu Leu Phe Cys Pro Lys Ser Lys Leu 
            20                  25                  30          


His Ile His Arg Ala Glu Ile Ser Lys Ile Met Arg Glu Cys Gln Glu 
        35                  40                  45              


Glu Ser Phe Trp Lys Arg Ala Leu Pro Phe Ser Leu Val Ser Met Leu 
    50                  55                  60                  


Val Thr Gln Gly Leu Val Tyr Gln Gly Tyr Leu Ala Ala Asn Ser Arg 
65                  70                  75                  80  


Phe Gly Ser Leu Pro Lys Val Ala Leu Ala Gly Leu Leu Gly Phe Gly 
                85                  90                  95      


Leu Gly Lys Val Ser Tyr Ile Gly Val Cys Gln Ser Lys Phe His Phe 
            100                 105                 110         


Phe Glu Asp Gln Leu Arg Gly Ala Gly Phe Gly Pro Gln His Asn Arg 
        115                 120                 125             


His Cys Leu Leu Thr Cys Glu Glu Cys Lys Ile Lys His Gly Leu Ser 
    130                 135                 140                 


Glu Lys Gly Asp Ser Gln Pro Ser Ala Ser 
145                 150                 


<210> 8410
<211> 839
<212> PRT
<213> Homo sapiens

<400> 8410
Met Ser Val Val Gly Ile Asp Leu Gly Phe Leu Asn Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ser Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ala Cys Ile Ser Leu Gly Ser Arg Thr Arg Ala Ile 
        35                  40                  45              


Gly Asn Ala Ala Lys Ser Gln Ile Val Thr Asn Val Arg Asn Thr Ile 
    50                  55                  60                  


His Gly Phe Lys Lys Leu His Gly Arg Ser Phe Asp Asp Pro Ile Val 
65                  70                  75                  80  


Gln Thr Glu Arg Ile Arg Leu Pro Tyr Glu Leu Gln Lys Met Pro Asn 
                85                  90                  95      


Gly Ser Ala Gly Val Lys Val Arg Tyr Leu Glu Glu Glu Arg Pro Phe 
            100                 105                 110         


Ala Ile Glu Gln Val Thr Gly Met Leu Leu Ala Lys Leu Lys Glu Thr 
        115                 120                 125             


Ser Glu Asn Ala Leu Lys Lys Pro Val Ala Asp Cys Val Ile Ser Ile 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Met Ala Ala Ala 
145                 150                 155                 160 


Gln Val Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                165                 170                 175     


Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Pro Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Asn Val Val Phe Ile Asp Met Gly His Ser Ala Tyr 
        195                 200                 205             


Gln Val Leu Val Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Ala 
    210                 215                 220                 


Thr Thr Phe Asp Pro Tyr Leu Gly Gly Arg Asn Phe Asp Glu Ala Leu 
225                 230                 235                 240 


Val Asp Tyr Phe Cys Asp Glu Phe Lys Thr Lys Tyr Lys Ile Asn Val 
                245                 250                 255     


Lys Glu Asn Ser Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Leu Asp Val Ser Ser Lys Met Asn Arg Ala 
    290                 295                 300                 


Gln Phe Glu Gln Leu Cys Ala Ser Leu Leu Ala Arg Val Glu Pro Pro 
305                 310                 315                 320 


Leu Lys Ala Val Met Glu Gln Ala Asn Leu Gln Arg Glu Asp Ile Ser 
                325                 330                 335     


Ser Ile Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Gln Ile Thr Lys Phe Phe Leu Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Leu Val Pro Tyr 
385                 390                 395                 400 


Ser Ile Thr Leu Arg Trp Lys Thr Ser Phe Glu Asp Gly Ser Gly Glu 
                405                 410                 415     


Cys Glu Val Phe Cys Lys Asn His Pro Ala Pro Phe Ser Lys Val Ile 
            420                 425                 430         


Thr Phe His Lys Lys Glu Pro Phe Glu Leu Glu Ala Phe Tyr Thr Asn 
        435                 440                 445             


Leu His Glu Val Pro Tyr Pro Asp Ala Arg Ile Gly Ser Phe Thr Ile 
    450                 455                 460                 


Gln Asn Val Phe Pro Gln Ser Asp Gly Asp Ser Ser Lys Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Ile His Gly Ile Phe Ser Val Ala Ser Ala Ser 
                485                 490                 495     


Val Ile Glu Lys Gln Asn Leu Glu Gly Asp His Ser Asp Ala Pro Met 
            500                 505                 510         


Glu Thr Glu Thr Ser Phe Lys Asn Glu Asn Lys Asp Asn Met Asp Lys 
        515                 520                 525             


Met Gln Val Asp Gln Glu Glu Gly His Gln Lys Cys His Ala Glu His 
    530                 535                 540                 


Thr Pro Glu Glu Glu Ile Asp His Thr Gly Ala Lys Thr Lys Ser Ala 
545                 550                 555                 560 


Val Ser Asp Lys Gln Asp Arg Leu Asn Gln Thr Leu Lys Lys Gly Lys 
                565                 570                 575     


Val Lys Ser Ile Asp Leu Pro Ile Gln Ser Ser Leu Cys Arg Gln Leu 
            580                 585                 590         


Gly Gln Asp Leu Leu Asn Ser Tyr Ile Glu Asn Glu Gly Lys Met Ile 
        595                 600                 605             


Met Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val 
    610                 615                 620                 


Glu Glu Tyr Val Tyr Asp Phe Arg Asp Arg Leu Gly Thr Val Tyr Glu 
625                 630                 635                 640 


Lys Phe Ile Thr Pro Glu Asp Leu Ser Lys Leu Ser Ala Val Leu Glu 
                645                 650                 655     


Asp Thr Glu Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln 
            660                 665                 670         


Val Tyr Val Asp Lys Leu Gln Glu Leu Lys Lys Tyr Gly Gln Pro Ile 
        675                 680                 685             


Gln Met Lys Tyr Met Glu His Glu Glu Arg Pro Lys Ala Leu Asn Asp 
    690                 695                 700                 


Leu Gly Lys Lys Ile Gln Leu Val Met Lys Val Ile Glu Ala Tyr Arg 
705                 710                 715                 720 


Asn Lys Asp Glu Arg Tyr Asp His Leu Asp Pro Thr Glu Met Glu Lys 
                725                 730                 735     


Val Glu Lys Cys Ile Ser Asp Ala Met Ser Trp Leu Asn Ser Lys Met 
            740                 745                 750         


Asn Ala Gln Asn Lys Leu Ser Leu Thr Gln Asp Pro Val Val Lys Val 
        755                 760                 765             


Ser Glu Ile Val Ala Lys Ser Lys Glu Leu Asp Asn Phe Cys Asn Pro 
    770                 775                 780                 


Ile Ile Tyr Lys Pro Lys Pro Lys Ala Glu Val Pro Glu Asp Lys Pro 
785                 790                 795                 800 


Lys Ala Asn Ser Glu His Asn Gly Pro Met Asp Gly Gln Ser Gly Thr 
                805                 810                 815     


Glu Thr Lys Ser Asp Ser Thr Lys Asp Ser Ser Gln His Thr Lys Ser 
            820                 825                 830         


Ser Gly Glu Met Glu Val Asp 
        835                 


<210> 8411
<211> 17
<212> PRT
<213> Homo sapiens

<400> 8411
Met Asp Glu Gly Met Glu Ile Ser Ser Glu Gly Asn Ser Leu Ile Lys 
1               5                   10                  15      


Ala 
    


<210> 8412
<211> 797
<212> PRT
<213> Homo sapiens

<400> 8412
Met Gly Val Ser Arg Leu Met Asp Leu Leu Ala Asp Ser Arg Glu Val 
1               5                   10                  15      


Ile Arg Asn Asp Gly Val Leu Leu Leu Gln Ala Leu Thr Arg Ser Asn 
            20                  25                  30          


Gly Ala Ile Gln Lys Ile Val Ala Phe Glu Asn Ala Phe Glu Arg Leu 
        35                  40                  45              


Leu Asp Ile Ile Ser Glu Glu Gly Asn Ser Asp Gly Gly Ile Val Val 
    50                  55                  60                  


Glu Asp Cys Leu Ile Leu Leu Gln Asn Leu Leu Lys Asn Asn Asn Ser 
65                  70                  75                  80  


Asn Gln Asn Phe Phe Lys Glu Gly Ser Tyr Ile Gln Arg Met Lys Pro 
                85                  90                  95      


Trp Phe Glu Val Gly Asp Glu Asn Ser Gly Trp Ser Ala Gln Lys Val 
            100                 105                 110         


Thr Asn Leu His Leu Met Leu Gln Leu Val Arg Val Leu Val Ser Pro 
        115                 120                 125             


Thr Asn Pro Pro Gly Ala Thr Ser Ser Cys Gln Lys Ala Met Phe Gln 
    130                 135                 140                 


Cys Gly Leu Leu Gln Gln Leu Cys Thr Ile Leu Met Ala Thr Gly Val 
145                 150                 155                 160 


Pro Ala Asp Ile Leu Thr Glu Thr Ile Asn Thr Val Ser Glu Val Ile 
                165                 170                 175     


Arg Gly Cys Gln Val Asn Gln Asp Tyr Phe Ala Ser Val Asn Ala Pro 
            180                 185                 190         


Ser Asn Pro Pro Arg Pro Ala Ile Val Val Leu Leu Met Ser Met Val 
        195                 200                 205             


Asn Glu Arg Gln Pro Phe Val Leu Arg Cys Ala Val Leu Tyr Cys Phe 
    210                 215                 220                 


Gln Cys Phe Leu Tyr Lys Asn Gln Lys Gly Gln Gly Glu Ile Val Ser 
225                 230                 235                 240 


Thr Leu Leu Pro Ser Thr Ile Asp Ala Thr Gly Asn Ser Val Ser Ala 
                245                 250                 255     


Gly Gln Leu Leu Cys Gly Gly Leu Phe Ser Thr Asp Ser Leu Ser Asn 
            260                 265                 270         


Trp Cys Ala Ala Val Ala Leu Ala His Ala Leu Gln Glu Asn Ala Thr 
        275                 280                 285             


Gln Lys Glu Gln Leu Leu Arg Val Gln Leu Ala Thr Ser Ile Gly Asn 
    290                 295                 300                 


Pro Pro Val Ser Leu Leu Gln Gln Cys Thr Asn Ile Leu Ser Gln Gly 
305                 310                 315                 320 


Ser Lys Ile Gln Thr Arg Val Gly Leu Leu Met Leu Leu Cys Thr Trp 
                325                 330                 335     


Leu Ser Asn Cys Pro Ile Ala Val Thr His Phe Leu His Asn Ser Ala 
            340                 345                 350         


Asn Val Pro Phe Leu Thr Gly Gln Ile Ala Glu Asn Leu Gly Glu Glu 
        355                 360                 365             


Glu Gln Leu Val Gln Gly Leu Cys Ala Leu Leu Leu Gly Ile Ser Ile 
    370                 375                 380                 


Tyr Phe Asn Asp Asn Ser Leu Glu Ser Tyr Met Lys Glu Lys Leu Lys 
385                 390                 395                 400 


Gln Leu Ile Glu Lys Arg Ile Gly Lys Glu Asn Phe Ile Glu Lys Leu 
                405                 410                 415     


Gly Phe Ile Ser Lys His Glu Leu Tyr Ser Arg Ala Ser Gln Lys Pro 
            420                 425                 430         


Gln Pro Asn Phe Pro Ser Pro Glu Tyr Met Ile Phe Asp His Glu Phe 
        435                 440                 445             


Thr Lys Leu Val Lys Glu Leu Glu Gly Val Ile Thr Lys Ala Ile Tyr 
    450                 455                 460                 


Lys Ser Ser Glu Glu Asp Lys Lys Glu Glu Glu Val Lys Lys Thr Leu 
465                 470                 475                 480 


Glu Gln His Asp Asn Ile Val Thr His Tyr Lys Asn Met Ile Arg Glu 
                485                 490                 495     


Gln Asp Leu Gln Leu Glu Glu Leu Arg Gln Gln Val Ser Thr Leu Lys 
            500                 505                 510         


Cys Gln Asn Glu Gln Leu Gln Thr Ala Val Thr Gln Gln Val Ser Gln 
        515                 520                 525             


Ile Gln Gln His Lys Asp Gln Tyr Asn Leu Leu Lys Ile Gln Leu Gly 
    530                 535                 540                 


Lys Asp Asn Gln His Gln Gly Ser Tyr Ser Glu Gly Ala Gln Met Asn 
545                 550                 555                 560 


Gly Ile Gln Pro Glu Glu Ile Gly Arg Leu Arg Glu Glu Ile Glu Glu 
                565                 570                 575     


Leu Lys Arg Asn Gln Glu Leu Leu Gln Ser Gln Leu Thr Glu Lys Asp 
            580                 585                 590         


Ser Met Ile Glu Asn Met Lys Ser Ser Gln Thr Ser Gly Thr Asn Glu 
        595                 600                 605             


Gln Ser Ser Ala Ile Val Ser Ala Arg Asp Ser Glu Gln Val Ala Glu 
    610                 615                 620                 


Leu Lys Gln Glu Leu Ala Thr Leu Lys Ser Gln Leu Asn Ser Gln Ser 
625                 630                 635                 640 


Val Glu Ile Thr Lys Leu Gln Thr Glu Lys Gln Glu Leu Leu Gln Lys 
                645                 650                 655     


Thr Glu Ala Phe Ala Lys Ser Val Glu Val Gln Gly Glu Thr Glu Thr 
            660                 665                 670         


Ile Ile Ala Thr Lys Thr Thr Asp Val Glu Gly Arg Leu Ser Ala Leu 
        675                 680                 685             


Leu Gln Glu Thr Lys Glu Leu Lys Asn Glu Ile Lys Ala Leu Ser Glu 
    690                 695                 700                 


Glu Arg Thr Ala Ile Lys Glu Gln Leu Asp Ser Ser Asn Ser Thr Ile 
705                 710                 715                 720 


Ala Ile Leu Gln Thr Glu Lys Asp Lys Leu Glu Leu Glu Ile Thr Asp 
                725                 730                 735     


Ser Lys Lys Glu Gln Asp Asp Leu Leu Val Leu Leu Ala Asp Gln Asp 
            740                 745                 750         


Gln Lys Ile Leu Ser Leu Lys Asn Lys Leu Lys Asp Leu Gly His Pro 
        755                 760                 765             


Val Glu Glu Glu Asp Glu Leu Glu Ser Gly Asp Gln Glu Asp Glu Asp 
    770                 775                 780                 


Asp Glu Ser Glu Asp Pro Gly Lys Asp Leu Asp His Ile 
785                 790                 795         


<210> 8413
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8413
Xaa Arg His Leu Arg Ala Thr Pro Asn Thr Arg Gly Ser Ala Arg Leu 
1               5                   10                  15      


Leu Cys Ala Glu Met Pro Lys Lys Ala Gly Ala Thr Thr Lys Gly Lys 
            20                  25                  30          


Ser Gln Ser Lys Glu Pro Glu Arg Pro Leu Pro Pro Leu Gly Pro Val 
        35                  40                  45              


Ala Val Asp Pro Lys Gly Cys Val Thr Ile Ala Ile His Ala Lys Pro 
    50                  55                  60                  


Gly Ser Lys Gln Asn Ala Val Thr Asp Leu Thr Ala Glu Ala Val Asn 
65                  70                  75                  80  


Val Ala Ile Ala Ala Pro Pro Ser Glu Gly Glu Ala Asn Ala Glu Leu 
                85                  90                  95      


Cys Arg Tyr Leu Ser Lys Val Leu Glu Leu Arg Lys Ser Asp Val Val 
            100                 105                 110         


Leu Asp Lys Lys Leu Arg Asp Leu Leu Lys Ile Val Pro Cys Lys Leu 
        115                 120                 125             


Ala Thr Arg Thr Gln Ile Leu Gly Leu Leu Val Glu Cys Ser Phe Ser 
    130                 135                 140                 


Arg Leu 
145     


<210> 8414
<211> 80
<212> PRT
<213> Homo sapiens

<400> 8414
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


<210> 8415
<211> 119
<212> PRT
<213> Homo sapiens

<400> 8415
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser 
        115                 


<210> 8416
<211> 22
<212> PRT
<213> Homo sapiens

<400> 8416
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg 
            20          


<210> 8417
<211> 352
<212> PRT
<213> Homo sapiens

<400> 8417
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gln Ile Leu Glu Lys 
            20                  25                  30          


Ala Ile Gln Leu Ser Gly Ala Glu Gln Leu Glu Ala Leu Lys Ala Phe 
        35                  40                  45              


Val Glu Ala Met Val Asn Glu Asn Val Ser Leu Val Ile Ser Arg Gln 
    50                  55                  60                  


Leu Leu Thr Asp Phe Cys Thr His Leu Pro Asn Leu Pro Asp Ser Thr 
65                  70                  75                  80  


Ala Lys Glu Ile Tyr His Phe Thr Leu Glu Lys Ile Gln Pro Arg Val 
                85                  90                  95      


Ile Ser Phe Glu Glu Gln Val Ala Ser Ile Arg Gln His Leu Ala Ser 
            100                 105                 110         


Ile Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gln Val Leu Val 
        115                 120                 125             


Gly Ile Pro Leu Glu Thr Gly Gln Lys Gln Tyr Asn Val Asp Tyr Lys 
    130                 135                 140                 


Leu Glu Thr Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
145                 150                 155                 160 


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
                165                 170                 175     


Glu Ser Thr Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
            180                 185                 190         


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
        195                 200                 205             


Asn Glu Leu Ser Tyr Lys Thr Ile Val His Glu Ser Glu Arg Leu Glu 
    210                 215                 220                 


Ala Leu Lys His Ala Leu His Cys Thr Ile Leu Ala Ser Ala Gly Gln 
225                 230                 235                 240 


Gln Arg Ser Arg Met Leu Ala Thr Leu Phe Lys Asp Glu Arg Cys Gln 
                245                 250                 255     


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
            260                 265                 270         


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
        275                 280                 285             


Gln Lys Ala Thr Thr Ala Asp Gly Ser Ser Ile Leu Asp Arg Ala Val 
    290                 295                 300                 


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Thr 
305                 310                 315                 320 


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys His Glu 
                325                 330                 335     


Lys Pro Cys Gln Arg Gly Ile Ser Arg Ser Asn His Phe Val Ser Lys 
            340                 345                 350         


<210> 8418
<211> 125
<212> PRT
<213> Homo sapiens

<400> 8418
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr 
        115                 120                 125 


<210> 8419
<211> 218
<212> PRT
<213> Homo sapiens

<400> 8419
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro Pro Val Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln 
            20                  25                  30          


Gly Leu Ile Ser Lys Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser 
        35                  40                  45              


Ile Pro Lys Leu Ile Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys 
    50                  55                  60                  


Leu Ser Tyr Val Lys Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn 
65                  70                  75                  80  


Ser Pro Leu Gly Glu Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser 
                85                  90                  95      


Pro Pro Gly His Tyr Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser 
            100                 105                 110         


Gly Gln Ser Ser Phe Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met 
        115                 120                 125             


Leu Pro His Tyr Glu Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser 
    130                 135                 140                 


Ala Pro Thr Gly Ile Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn 
145                 150                 155                 160 


Leu Glu Glu Ser Pro Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg 
                165                 170                 175     


Asn Lys Asn Arg Glu Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp 
            180                 185                 190         


Pro Ser Val Arg Pro Met His Glu Arg Val Pro Lys Lys Glu Val Lys 
        195                 200                 205             


Val Asn Lys Tyr Gly Asp Thr Trp Asp Glu 
    210                 215             


<210> 8420
<211> 80
<212> PRT
<213> Homo sapiens

<400> 8420
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


<210> 8421
<211> 217
<212> PRT
<213> Homo sapiens

<400> 8421
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110         


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125             


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140                 


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys 
145                 150                 155                 160 


Asn Leu Pro Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu 
                165                 170                 175     


Lys Asn Arg Tyr Arg Asp Ile Leu Pro Phe Gln His His Gly Tyr Ser 
            180                 185                 190         


Gly Pro Asn Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala 
        195                 200                 205             


Val Ser Leu Leu Leu Arg Tyr Cys Ala 
    210                 215         


<210> 8422
<211> 116
<212> PRT
<213> Homo sapiens

<400> 8422
Met Gly Arg Leu Asp Gly Lys Val Ile Ile Leu Thr Ala Ala Ala Gln 
1               5                   10                  15      


Gly Ile Gly Gln Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Ala Thr Asp Ile Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys 
        35                  40                  45              


Tyr Pro Gly Ile Gln Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gln 
    50                  55                  60                  


Ile Asp Gln Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn 
65                  70                  75                  80  


Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys 
                85                  90                  95      


Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met 
            100                 105                 110         


Ile Lys Ala Phe 
        115     


<210> 8423
<211> 167
<212> PRT
<213> Homo sapiens

<400> 8423
Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr Cys Asp Cys Lys Ile Phe Lys Ile 
        35                  40                  45              


Cys Leu Val Val Thr Lys Glu Val Ser Arg Asp Ser Ser Leu Leu Arg 
    50                  55                  60                  


Asp Asp Leu Ile Gln Asp Val Glu Ile Gln Ile Ile Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Pro Pro Ile Val Gln Asn Cys Cys Leu Pro Ala Val Val Glu Arg 
                85                  90                  95      


Ser Asp Asn Phe Cys Arg Ala Gly Leu Ala Val Val Leu Arg His Ile 
            100                 105                 110         


Ile Gln Lys Ser Tyr Glu Ala Asp Pro Leu Lys Lys Glu Leu Leu Glu 
        115                 120                 125             


Leu Leu Gly Phe Lys Lys Thr Cys Leu Lys Ala Cys Ala Glu Val Ser 
    130                 135                 140                 


Gln Trp Thr Arg Leu Cys Glu Leu Thr Ile Pro Leu Ala Ile Glu Asn 
145                 150                 155                 160 


Phe Leu Arg Glu Ser Ser Asp 
                165         


<210> 8424
<211> 310
<212> PRT
<213> Homo sapiens

<400> 8424
Met Ser Gln Gln Leu Lys Lys Arg Ala Lys Thr Arg His Gln Lys Gly 
1               5                   10                  15      


Leu Gly Gly Arg Ala Pro Ser Gly Ala Lys Pro Arg Gln Gly Lys Ser 
            20                  25                  30          


Ser Gln Asp Leu Gln Ala Glu Ile Glu Pro Val Ser Ala Val Trp Ala 
        35                  40                  45              


Leu Cys Asp Gly Tyr Val Cys Tyr Glu Pro Gly Pro Gln Ala Leu Gly 
    50                  55                  60                  


Gly Asp Asp Phe Ser Asp Cys Tyr Ile Glu Cys Val Ile Arg Gly Glu 
65                  70                  75                  80  


Phe Ser Gln Pro Ile Leu Glu Glu Asp Ser Leu Phe Glu Ser Leu Glu 
                85                  90                  95      


Tyr Leu Lys Lys Gly Ser Glu Gln Gln Leu Ser Gln Lys Val Phe Glu 
            100                 105                 110         


Ala Ser Ser Leu Glu Cys Ser Leu Glu Tyr Met Lys Lys Gly Val Lys 
        115                 120                 125             


Lys Glu Leu Pro Gln Lys Ile Val Gly Glu Asn Ser Leu Glu Tyr Ser 
    130                 135                 140                 


Glu Tyr Met Thr Gly Lys Lys Leu Pro Pro Gly Gly Ile Pro Gly Ile 
145                 150                 155                 160 


Asp Leu Ser Asp Pro Lys Gln Leu Ala Glu Phe Ala Arg Lys Lys Pro 
                165                 170                 175     


Pro Ile Asn Lys Glu Tyr Asp Ser Leu Ser Ala Ile Ala Cys Pro Gln 
            180                 185                 190         


Ser Gly Cys Thr Arg Lys Leu Arg Asn Arg Ala Ala Leu Arg Lys His 
        195                 200                 205             


Leu Leu Ile His Gly Pro Arg Asp His Val Cys Ala Glu Cys Gly Lys 
    210                 215                 220                 


Ala Phe Val Glu Ser Ser Lys Leu Lys Arg His Phe Leu Val His Thr 
225                 230                 235                 240 


Gly Glu Lys Pro Phe Arg Cys Thr Phe Glu Gly Cys Gly Lys Arg Phe 
                245                 250                 255     


Ser Leu Asp Phe Asn Leu Arg Thr His Val Arg Ile His Thr Gly Glu 
            260                 265                 270         


Lys Arg Phe Val Cys Pro Phe Gln Gly Cys Asn Arg Arg Phe Ile Gln 
        275                 280                 285             


Ser Asn Asn Leu Lys Ala His Ile Leu Thr His Ala Asn Thr Asn Lys 
    290                 295                 300                 


Asn Glu Gln Glu Gly Lys 
305                 310 


<210> 8425
<211> 78
<212> PRT
<213> Homo sapiens

<400> 8425
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg 
65                  70                  75              


<210> 8426
<211> 226
<212> PRT
<213> Homo sapiens

<400> 8426
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175     


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190         


Leu Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr 
        195                 200                 205             


Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr 
    210                 215                 220                 


Cys Ala 
225     


<210> 8427
<211> 339
<212> PRT
<213> Homo sapiens

<400> 8427
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr Ile 
        115                 120                 125             


Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe Tyr 
    130                 135                 140                 


Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp Gln 
145                 150                 155                 160 


Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg Glu 
                165                 170                 175     


Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn Tyr 
        195                 200                 205             


Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu Lys 
    210                 215                 220                 


Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys Trp 
225                 230                 235                 240 


Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile 
                245                 250                 255     


Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His Cys 
            260                 265                 270         


Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val Val 
        275                 280                 285             


Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile Val 
    290                 295                 300                 


Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln 
305                 310                 315                 320 


Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu 
                325                 330                 335     


Thr Leu Asp 
            


<210> 8428
<211> 392
<212> PRT
<213> Homo sapiens

<400> 8428
Met Gly Thr Thr Cys Leu His Leu Gly Thr Leu Glu Gln Ser Leu Val 
1               5                   10                  15      


Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn 
            20                  25                  30          


Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser 
        35                  40                  45              


Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp 
    50                  55                  60                  


Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu 
65                  70                  75                  80  


Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu 
                85                  90                  95      


Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln 
            100                 105                 110         


Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala 
        115                 120                 125             


Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro 
    130                 135                 140                 


Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg 
145                 150                 155                 160 


Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys 
                165                 170                 175     


Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly 
            180                 185                 190         


Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile 
        195                 200                 205             


Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala 
    210                 215                 220                 


Met Ile Thr Arg Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr 
225                 230                 235                 240 


Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val 
                245                 250                 255     


Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe 
            260                 265                 270         


Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu 
        275                 280                 285             


Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser 
    290                 295                 300                 


Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro 
305                 310                 315                 320 


Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu 
                325                 330                 335     


Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn 
            340                 345                 350         


Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val 
        355                 360                 365             


Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val 
    370                 375                 380                 


Leu Arg Lys Leu Leu Thr Leu Asp 
385                 390         


<210> 8429
<211> 217
<212> PRT
<213> Homo sapiens

<400> 8429
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110         


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125             


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140                 


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys 
145                 150                 155                 160 


Asn Leu Pro Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu 
                165                 170                 175     


Lys Asn Arg Tyr Arg Asp Ile Leu Pro Phe Gln His His Gly Tyr Ser 
            180                 185                 190         


Gly Pro Asn Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala 
        195                 200                 205             


Val Ser Leu Leu Leu Arg Tyr Cys Ala 
    210                 215         


<210> 8430
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8430
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95      


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110         


Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe 
        115                 120                 125             


Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys 
    130                 135                 140                 


Ala 
145 


<210> 8431
<211> 68
<212> PRT
<213> Homo sapiens

<400> 8431
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp 
65              


<210> 8432
<211> 174
<212> PRT
<213> Homo sapiens

<400> 8432
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr 
                165                 170                 


<210> 8433
<211> 134
<212> PRT
<213> Homo sapiens

<400> 8433
Met Ser Asp Asp Ala Gly Asp Thr Leu Ala Thr Gly Asp Lys Ala Glu 
1               5                   10                  15      


Val Thr Glu Met Pro Asn Ser Asp Ser Leu Pro Glu Asp Ala Glu Val 
            20                  25                  30          


His Cys Asp Ser Ala Ala Val Ser His Glu Pro Thr Pro Ala Asp Pro 
        35                  40                  45              


Arg Gly Glu Gly His Glu Asn Ala Ala Val Gln Gly Ala Gly Ala Ala 
    50                  55                  60                  


Ala Ile Gly Pro Pro Val Gln Pro Gln Asp Ala Asn Ala Leu Glu Pro 
65                  70                  75                  80  


Pro Leu Asn Gly Asp Val Thr Glu Asp Thr Leu Ala Glu Cys Ile Asp 
                85                  90                  95      


Ser Val Ser Leu Glu Ala Glu Pro Arg Ser Glu Ile Pro Leu Gln Glu 
            100                 105                 110         


Gln Asn Tyr Leu Ala Val Asp Ser Pro Pro Ser Gly Gly Gly Trp Ala 
        115                 120                 125             


Gly Trp Gly Ser Trp Gly 
    130                 


<210> 8434
<211> 143
<212> PRT
<213> Homo sapiens

<400> 8434
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg Tyr Asp Leu 
    130                 135                 140             


<210> 8435
<211> 399
<212> PRT
<213> Homo sapiens

<400> 8435
Met Asp Phe Phe Ser Ser His Leu Leu Ala Asp Ser Ser Ser Pro Ala 
1               5                   10                  15      


Thr Asn Ser Ser His Thr Asp Ala His Glu Ile Leu Val Ser Asp Phe 
            20                  25                  30          


Leu Val Ser Asp Glu Asn Leu Gln Lys Met Glu Asn Val Leu Asp Leu 
        35                  40                  45              


Trp Ser Ser Gly Leu Lys Thr Asn Ile Ile Ser Glu Leu Ser Lys Trp 
    50                  55                  60                  


Arg Leu Asn Phe Ile Asp Trp His Arg Met Glu Met Arg Lys Glu Lys 
65                  70                  75                  80  


Glu Lys His Ala Ala His Leu Lys Gln Leu Cys Asn Gln Ile Asn Glu 
                85                  90                  95      


Leu Lys Glu Leu Gln Lys Thr Phe Glu Ile Ser Ile Gly Arg Lys Asp 
            100                 105                 110         


Glu Val Ile Ser Ser Leu Ser His Ala Ile Gly Lys Gln Lys Glu Lys 
        115                 120                 125             


Ile Glu Leu Met Arg Thr Phe Phe His Trp Arg Ile Gly His Val Arg 
    130                 135                 140                 


Ala Arg Gln Asp Val Tyr Glu Gly Lys Leu Ala Asp Gln Tyr Tyr Gln 
145                 150                 155                 160 


Arg Thr Leu Leu Lys Lys Val Trp Lys Val Trp Arg Ser Val Val Gln 
                165                 170                 175     


Lys Gln Trp Lys Asp Val Val Glu Arg Ala Cys Gln Ala Arg Ala Glu 
            180                 185                 190         


Glu Val Cys Ile Gln Ile Ser Asn Asp Tyr Glu Ala Lys Val Ala Met 
        195                 200                 205             


Leu Ser Gly Ala Leu Glu Asn Ala Lys Ala Glu Ile Gln Arg Met Gln 
    210                 215                 220                 


His Glu Lys Glu His Phe Glu Asp Ser Met Lys Lys Ala Phe Met Arg 
225                 230                 235                 240 


Gly Val Cys Ala Leu Asn Leu Glu Ala Met Thr Ile Phe Gln Asn Arg 
                245                 250                 255     


Asn Asp Ala Gly Ile Asp Ser Thr Asn Asn Lys Lys Glu Glu Tyr Gly 
            260                 265                 270         


Pro Gly Val Gln Gly Lys Glu His Ser Ala His Leu Asp Pro Ser Ala 
        275                 280                 285             


Pro Pro Met Pro Leu Pro Val Thr Ser Pro Leu Leu Pro Ser Pro Pro 
    290                 295                 300                 


Ala Ala Val Gly Gly Ala Ser Ala Thr Ala Val Pro Ser Ala Ala Ser 
305                 310                 315                 320 


Met Thr Ser Thr Arg Ala Ala Ser Ala Ser Ser Val His Val Pro Val 
                325                 330                 335     


Ser Ala Leu Gly Ala Gly Ser Ala Ala Thr Ala Ala Ser Glu Glu Met 
            340                 345                 350         


Gln Thr Ile Pro Gln Ala Thr Ala Ala Lys Tyr Pro Arg Thr Ile His 
        355                 360                 365             


Pro Glu Ser Ser Thr Ser Ala Ser Arg Ser Leu Gly Thr Arg Ser Ala 
    370                 375                 380                 


His Thr Gln Ser Leu Thr Ser Val His Ser Ile Lys Val Val Asp 
385                 390                 395                 


<210> 8436
<211> 79
<212> PRT
<213> Homo sapiens

<400> 8436
Met Asp Glu Ser Ala Leu Leu Asp Leu Leu Glu Cys Pro Val Cys Leu 
1               5                   10                  15      


Glu Arg Leu Asp Ala Ser Ala Lys Val Leu Pro Cys Gln His Thr Phe 
            20                  25                  30          


Cys Lys Arg Cys Leu Leu Gly Ile Val Gly Ser Arg Asn Glu Leu Arg 
        35                  40                  45              


Cys Pro Glu Cys Arg Thr Leu Val Gly Ser Gly Val Glu Glu Leu Pro 
    50                  55                  60                  


Ser Asn Ile Leu Leu Val Arg Leu Leu Asp Gly Ile Lys Gln Arg 
65                  70                  75                  


<210> 8437
<211> 206
<212> PRT
<213> Homo sapiens

<400> 8437
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu 
                165                 170                 175     


Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr 
            180                 185                 190         


Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
        195                 200                 205     


<210> 8438
<211> 166
<212> PRT
<213> Homo sapiens

<400> 8438
Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr Cys Asp Cys Lys Ile Phe Lys Ile 
        35                  40                  45              


Cys Leu Val Val Thr Lys Glu Val Ser Arg Asp Ser Ser Leu Leu Arg 
    50                  55                  60                  


Asp Asp Leu Ile Gln Asp Val Glu Ile Gln Ile Ile Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Pro Pro Ile Val Gln Asn Cys Cys Leu Pro Ala Val Val Glu Arg 
                85                  90                  95      


Ser Asp Asn Phe Cys Arg Ala Gly Leu Ala Val Val Leu Arg His Ile 
            100                 105                 110         


Ile Gln Lys Ser Tyr Glu Ala Asp Pro Leu Lys Lys Glu Leu Leu Glu 
        115                 120                 125             


Leu Leu Gly Phe Lys Lys Thr Cys Leu Lys Ala Cys Ala Glu Val Ser 
    130                 135                 140                 


Gln Trp Thr Arg Leu Cys Glu Leu Thr Ile Pro Leu Ala Ile Glu Asn 
145                 150                 155                 160 


Phe Leu Arg Glu Ser Ser 
                165     


<210> 8439
<211> 120
<212> PRT
<213> Homo sapiens

<400> 8439
Met Trp Lys Val Val Asn Leu Pro Thr Asp Leu Phe Asn Ser Val Met 
1               5                   10                  15      


Asn Val Gly Arg Phe Thr Glu Glu Ile Glu Trp Leu Lys Phe Leu Ala 
            20                  25                  30          


Leu Ala Cys Ser Ala Leu Gly Val Thr Ile Thr Lys Thr Leu Lys Ile 
        35                  40                  45              


Val Cys Glu Val Leu Ser Cys Asp His Asn Gly Gly Leu Pro Arg Ile 
    50                  55                  60                  


Pro Phe Ser Thr Phe Gln Phe Leu Tyr Thr Tyr Ile Ala Glu Val Asp 
65                  70                  75                  80  


Gly Glu Ile Cys Ala Ser His Val Ser Arg Met Leu Asn Tyr Ile Glu 
                85                  90                  95      


Gln Glu Val Ile Gly Pro Asp Gly Leu Ile Thr Val Asn Asp Phe Thr 
            100                 105                 110         


Gln Asn Pro Arg Val Trp Leu Glu 
        115                 120 


<210> 8440
<211> 116
<212> PRT
<213> Homo sapiens

<400> 8440
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro 
        115     


<210> 8441
<211> 159
<212> PRT
<213> Homo sapiens

<400> 8441
Met Ser Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr 
1               5                   10                  15      


Thr Gly His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu 
            20                  25                  30          


Asn Asp Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His 
        35                  40                  45              


Ile Glu Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu 
    50                  55                  60                  


Phe Ala Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala 
65                  70                  75                  80  


Asn Met Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly 
                85                  90                  95      


Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Leu Gly Gly Met Gly Leu 
            100                 105                 110         


Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu Ser Gly 
        115                 120                 125             


Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly Tyr Asp 
    130                 135                 140                 


Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile Ala 
145                 150                 155                 


<210> 8442
<211> 136
<212> PRT
<213> Homo sapiens

<400> 8442
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Val Gln His His Gly Tyr Ser Gly 
            100                 105                 110         


Pro Asn Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala Val 
        115                 120                 125             


Ser Leu Leu Leu Arg Tyr Cys Ala 
    130                 135     


<210> 8443
<211> 153
<212> PRT
<213> Homo sapiens

<400> 8443
Met Lys Leu Thr Ser Glu Lys Leu Pro Lys Asn Pro Phe Tyr Ala Ser 
1               5                   10                  15      


Val Ser Gln Tyr Ala Ala Lys Asn Gln Lys Phe Phe Gln Trp Lys Lys 
            20                  25                  30          


Glu Lys Thr Asp Tyr Thr His Ala Asn Leu Val Asp Lys Ala Leu Gln 
        35                  40                  45              


Leu Leu Lys Glu Arg Ile Leu Lys Gly Asp Thr Leu Ala Tyr Phe Leu 
    50                  55                  60                  


Arg Gly Gln Leu Tyr Phe Glu Glu Gly Trp Tyr Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Gln Phe Glu Glu Ile Lys Glu Lys Asp His Gln Ala Thr Tyr Gln Leu 
                85                  90                  95      


Gly Val Met Tyr Tyr Asp Gly Leu Gly Thr Thr Leu Asp Ala Glu Lys 
            100                 105                 110         


Gly Val Asp Tyr Met Lys Lys Ile Leu Asp Ser Pro Cys Pro Lys Ala 
        115                 120                 125             


Arg His Leu Lys Phe Ala Ala Ala Tyr Asn Leu Gly Arg Ala Tyr Tyr 
    130                 135                 140                 


Glu Gly Lys Gly Val Lys Arg Ser Asn 
145                 150             


<210> 8444
<211> 162
<212> PRT
<213> Homo sapiens

<400> 8444
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile 
        


<210> 8445
<211> 509
<212> PRT
<213> Homo sapiens

<400> 8445
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg Tyr Asp Leu Asn 
    130                 135                 140                 


Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu Glu Phe Lys Glu 
145                 150                 155                 160 


Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu Arg Val Leu Glu 
                165                 170                 175     


Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His Ala Ile Glu Thr 
            180                 185                 190         


Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val Val Cys Asp Val 
        195                 200                 205             


Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met Val Phe Cys Asp 
    210                 215                 220                 


Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val 
225                 230                 235                 240 


Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu Gly Val Gln Pro 
                245                 250                 255     


Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met Lys Pro Thr Arg 
            260                 265                 270         


Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu Trp Ile Pro Glu 
        275                 280                 285             


Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile Thr Lys Val Ser 
    290                 295                 300                 


His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser Leu Cys Asn Glu 
305                 310                 315                 320 


Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn Cys Arg Thr Ala 
                325                 330                 335     


Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu Met Lys Thr Ile 
            340                 345                 350         


Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr Cys Pro Lys His 
        355                 360                 365             


Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys Gly Ala Ala Gln 
    370                 375                 380                 


Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro Leu Glu Pro Phe 
385                 390                 395                 400 


Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg Val Ser Val Arg 
                405                 410                 415     


Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr Thr Phe Val Asn 
            420                 425                 430         


Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu Glu Val Val Asp 
        435                 440                 445             


Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val Asn Phe Asn Lys 
    450                 455                 460                 


Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn Leu Ala Lys Arg 
465                 470                 475                 480 


Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe Thr His Leu Arg 
                485                 490                 495     


Gln Asp Leu Glu Arg Val Met Ile Asp Thr Asp Thr Leu 
            500                 505                 


<210> 8446
<211> 29
<212> PRT
<213> Homo sapiens

<400> 8446
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu 
            20                  25                  


<210> 8447
<211> 411
<212> PRT
<213> Homo sapiens

<400> 8447
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110         


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125             


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140                 


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys 
145                 150                 155                 160 


Asn Leu Pro Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu 
                165                 170                 175     


Lys Asn Arg Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro 
            180                 185                 190         


Leu Gly Lys Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val 
        195                 200                 205             


Asn Cys Gly Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu 
    210                 215                 220                 


Ser Thr Ile Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn 
225                 230                 235                 240 


Val Ile Ala Met Ile Thr Arg Glu Ile Glu Gly Gly Ile Ile Lys Cys 
                245                 250                 255     


Tyr His Tyr Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His 
            260                 265                 270         


Phe Arg Val Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile 
        275                 280                 285             


Arg Met Phe Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val 
    290                 295                 300                 


Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser 
305                 310                 315                 320 


Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu 
                325                 330                 335     


Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly 
            340                 345                 350         


Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys 
        355                 360                 365             


Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser 
    370                 375                 380                 


Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val 
385                 390                 395                 400 


Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
                405                 410     


<210> 8448
<211> 99
<212> PRT
<213> Homo sapiens

<400> 8448
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser 
            


<210> 8449
<211> 234
<212> PRT
<213> Homo sapiens

<400> 8449
Met Ala Ser Ser Ala Lys Ser Ala Glu Met Pro Thr Ile Ser Lys Thr 
1               5                   10                  15      


Val Asn Pro Thr Pro Asp Pro His Gln Glu Tyr Leu Asp Pro Arg Ile 
            20                  25                  30          


Thr Ile Ala Leu Phe Glu Ile Gly Ser His Ser Pro Ser Ser Trp Gly 
        35                  40                  45              


Ser Leu Pro Phe Leu Lys Asn Ser Ser His Gln Val Thr Glu Gln Gln 
    50                  55                  60                  


Thr Ala Gln Lys Phe Asn Asn Leu Leu Lys Glu Ile Lys Asp Ile Leu 
65                  70                  75                  80  


Lys Asn Met Ala Gly Phe Glu Glu Lys Ile Thr Glu Ala Lys Glu Leu 
                85                  90                  95      


Phe Glu Glu Thr Asn Ile Thr Glu Asp Val Ser Ala His Lys Glu Asn 
            100                 105                 110         


Ile Arg Gly Leu Asp Lys Ile Asn Glu Met Leu Ser Thr Asn Leu Pro 
        115                 120                 125             


Val Ser Leu Ala Pro Glu Lys Glu Asp Asn Glu Lys Lys Gln Glu Met 
    130                 135                 140                 


Ile Leu Glu Thr Asn Ile Thr Glu Asp Val Ser Ala His Lys Glu Asn 
145                 150                 155                 160 


Ile Arg Gly Leu Asp Lys Ile Asn Glu Met Leu Ser Thr Asn Leu Pro 
                165                 170                 175     


Val Ser Leu Ala Pro Glu Lys Glu Asp Asn Glu Lys Lys Gln Gln Met 
            180                 185                 190         


Ile Met Glu Asn Gln Asn Ser Glu Asn Thr Ala Gln Val Phe Ala Arg 
        195                 200                 205             


Asp Leu Val Asn Arg Leu Glu Glu Lys Lys Val Leu Asn Glu Thr Gln 
    210                 215                 220                 


Gln Ser Gln Glu Lys Ala Lys Asn Arg Leu 
225                 230                 


<210> 8450
<211> 364
<212> PRT
<213> Homo sapiens

<400> 8450
Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Ser Tyr His Thr Leu Ala Tyr Val His 
    290                 295                 300                 


Thr Thr Gly Gln Val Val Ser Phe Gly His Gly Pro Ser Asp Thr Ser 
305                 310                 315                 320 


Lys Pro Thr His Pro Glu Ala Leu Thr Glu Asn Phe Asp Ile Ser Cys 
                325                 330                 335     


Leu Ile Ser Ala Glu Asp Phe Val Asp Val Gln Val Lys His Ile Phe 
            340                 345                 350         


Ala Gly Thr Tyr Ala Asn Phe Val Thr Thr His Gln 
        355                 360                 


<210> 8451
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8451
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro 
        115 


<210> 8452
<211> 161
<212> PRT
<213> Homo sapiens

<400> 8452
Met Ala Gly Ile Leu Arg Leu Val Val Gln Trp Pro Pro Gly Arg Leu 
1               5                   10                  15      


Gln Thr Val Thr Lys Gly Val Glu Ser Leu Ile Cys Thr Asp Trp Ile 
            20                  25                  30          


Arg His Lys Phe Thr Arg Ser Arg Ile Pro Glu Lys Val Phe Gln Ala 
        35                  40                  45              


Ser Pro Glu Asp His Glu Lys Tyr Gly Gly Asp Pro Gln Asn Pro His 
    50                  55                  60                  


Lys Leu His Ile Val Thr Arg Ile Lys Ser Thr Arg Arg Arg Pro Tyr 
65                  70                  75                  80  


Trp Glu Lys Asp Ile Ile Lys Met Leu Gly Leu Glu Lys Ala His Thr 
                85                  90                  95      


Pro Gln Val His Lys Asn Ile Pro Ser Val Asn Ala Lys Leu Lys Val 
            100                 105                 110         


Val Lys His Leu Ile Arg Ile Lys Pro Leu Lys Leu Pro Gln Gly Leu 
        115                 120                 125             


Pro Ala Glu Glu Asn Met Ser Asn Thr Cys Leu Lys Ser Thr Gly Glu 
    130                 135                 140                 


Leu Val Val Gln Trp His Leu Lys Pro Val Glu Gln Lys Ala His Glu 
145                 150                 155                 160 


Ser 
    


<210> 8453
<211> 171
<212> PRT
<213> Homo sapiens

<400> 8453
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser 
                165                 170     


<210> 8454
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8454
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Val Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe 
        115                 120                 125             


Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys 
    130                 135                 140                 


Ala 
145 


<210> 8455
<211> 80
<212> PRT
<213> Homo sapiens

<400> 8455
Met Val Thr Ser Leu Asn Glu Asp Asn Glu Ser Val Thr Val Glu Trp 
1               5                   10                  15      


Ile Glu Asn Gly Asp Thr Lys Gly Lys Glu Ile Asp Leu Glu Ser Ile 
            20                  25                  30          


Phe Ser Leu Asn Pro Asp Leu Val Pro Asp Glu Glu Ile Glu Pro Ser 
        35                  40                  45              


Pro Glu Thr Pro Pro Pro Pro Ala Ser Ser Ala Lys Val Asn Lys Ile 
    50                  55                  60                  


Val Lys Asn Arg Arg Thr Val Ala Ser Ile Lys Asn Asp Pro Pro Ser 
65                  70                  75                  80  


<210> 8456
<211> 40
<212> PRT
<213> Homo sapiens

<400> 8456
Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr 
        35                  40  


<210> 8457
<211> 63
<212> PRT
<213> Homo sapiens

<400> 8457
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser 
    50                  55                  60              


<210> 8458
<211> 197
<212> PRT
<213> Homo sapiens

<400> 8458
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr 
                85                  90                  95      


Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys 
            100                 105                 110         


Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val 
        115                 120                 125             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp 
    130                 135                 140                 


Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp 
145                 150                 155                 160 


Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys 
                165                 170                 175     


Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys 
            180                 185                 190         


Leu Leu Thr Leu Asp 
        195         


<210> 8459
<211> 842
<212> PRT
<213> Homo sapiens

<400> 8459
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg Tyr Asp Leu Asn 
    130                 135                 140                 


Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu Glu Phe Lys Glu 
145                 150                 155                 160 


Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu Arg Val Leu Glu 
                165                 170                 175     


Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His Ala Ile Glu Thr 
            180                 185                 190         


Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val Val Cys Asp Val 
        195                 200                 205             


Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met Val Phe Cys Asp 
    210                 215                 220                 


Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val 
225                 230                 235                 240 


Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu Gly Val Gln Pro 
                245                 250                 255     


Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met Lys Pro Thr Arg 
            260                 265                 270         


Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu Trp Ile Pro Glu 
        275                 280                 285             


Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile Thr Lys Val Ser 
    290                 295                 300                 


His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser Leu Cys Asn Glu 
305                 310                 315                 320 


Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn Cys Arg Thr Ala 
                325                 330                 335     


Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu Met Lys Thr Ile 
            340                 345                 350         


Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr Cys Pro Lys His 
        355                 360                 365             


Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys Gly Ala Ala Gln 
    370                 375                 380                 


Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro Leu Glu Pro Phe 
385                 390                 395                 400 


Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg Val Ser Val Arg 
                405                 410                 415     


Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr Thr Phe Val Asn 
            420                 425                 430         


Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu Glu Val Val Asp 
        435                 440                 445             


Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val Asn Phe Asn Lys 
    450                 455                 460                 


Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn Leu Ala Lys Arg 
465                 470                 475                 480 


Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe Thr His Leu Arg 
                485                 490                 495     


Gln Asp Leu Glu Arg Val Arg Asn Leu Thr Tyr Met Val Thr Arg Arg 
            500                 505                 510         


Glu Lys Ile Lys Arg Ser Val Cys Lys Val Gln Glu Gln Ile Phe Asn 
        515                 520                 525             


Leu Tyr Thr Lys Leu Leu Glu Gln Glu Arg Val Ser Gly Val Pro Ser 
    530                 535                 540                 


Ser Cys Ser Ser Ser Ser Leu Glu Asn Met Leu Leu Phe Asn Ser Pro 
545                 550                 555                 560 


Ser Val Gly Pro Asp Ala Pro Lys Ile Glu Asp Leu Lys Trp His Ser 
                565                 570                 575     


Ala Phe Phe Arg Lys Gln Met Gly Thr Ser Leu Val His Ser Leu Lys 
            580                 585                 590         


Lys Pro His Lys Arg Asp Pro Leu Gln Asn Ser Pro Gly Ser Glu Gly 
        595                 600                 605             


Lys Thr Leu Leu Lys Gln Pro Asp Leu Cys Gly Arg Arg Glu Gly Met 
    610                 615                 620                 


Val Val Pro Glu Ser Phe Leu Gly Leu Glu Lys Thr Phe Ala Glu Ala 
625                 630                 635                 640 


Arg Leu Ile Ser Ala Gln Gln Lys Asn Gly Val Val Met Pro Asp His 
                645                 650                 655     


Gly Lys Arg Arg Asp Asn Arg Phe His Cys Asp Leu Ile Lys Gly Asp 
            660                 665                 670         


Leu Lys Asp Lys Ser Phe Lys Gln Ser His Lys Pro Leu Arg Ser Thr 
        675                 680                 685             


Asp Val Ser Gln Arg His Leu Asp Asn Thr Arg Ala Ala Thr Ser Pro 
    690                 695                 700                 


Gly Val Gly Gln Ser Ala Pro Gly Thr Arg Lys Glu Ile Val Pro Lys 
705                 710                 715                 720 


Cys Asn Gly Ser Leu Ile Lys Val Asn Tyr Asn Gln Thr Ala Val Lys 
                725                 730                 735     


Val Pro Thr Thr Pro Ala Ser Pro Val Lys Asn Trp Gly Gly Phe Arg 
            740                 745                 750         


Ile Pro Lys Lys Gly Glu Arg Gln Gln Gln Gly Glu Ala His Asp Gly 
        755                 760                 765             


Ala Cys His Gln His Ser Asp Tyr Pro Tyr Leu Gly Leu Gly Arg Val 
    770                 775                 780                 


Pro Ala Lys Glu Arg Ala Lys Ser Lys Leu Lys Ser Asp Asn Glu Asn 
785                 790                 795                 800 


Asp Gly Tyr Val Pro Asp Val Glu Met Ser Asp Ser Glu Ser Glu Ala 
                805                 810                 815     


Ser Glu Lys Lys Cys Ile His Thr Ser Ser Thr Ile Ser Arg Arg Thr 
            820                 825                 830         


Asp Ile Ile Arg Arg Ser Ile Leu Ala Ser 
        835                 840         


<210> 8460
<211> 829
<212> PRT
<213> Homo sapiens

<400> 8460
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala 
        435                 440                 445             


Gly Asn Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Ser Thr Leu Gln 
625                 630                 635                 640 


Val Gln Glu Lys Ser Asn Thr Trp Ser Trp Gly Ile Leu Lys Met Leu 
                645                 650                 655     


Lys Gly Lys Asp Asp Arg Lys Lys Ser Ile Arg Glu Lys Pro Lys Val 
            660                 665                 670         


Ser Asp Ser Asp Asn Asn Glu Gly Ser Ser Phe Pro Ala Pro Pro Lys 
        675                 680                 685             


Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr Ser Asp 
    690                 695                 700                 


Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val Gly Lys 
705                 710                 715                 720 


Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln Glu Lys 
                725                 730                 735     


Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly Glu Ile Arg 
            740                 745                 750         


Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile Thr Ser Lys Lys Trp 
        755                 760                 765             


Gly Thr Arg Asp Leu Gln Val Lys Pro Gly Glu Ser Leu Glu Val Ile 
    770                 775                 780                 


Gln Thr Thr Asp Asp Thr Lys Val Leu Cys Arg Asn Glu Glu Gly Lys 
785                 790                 795                 800 


Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly Glu Ile 
                805                 810                 815     


Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp 
            820                 825                 


<210> 8461
<211> 269
<212> PRT
<213> Homo sapiens

<400> 8461
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110         


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125             


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140                 


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Thr Gly Thr Ser His 
145                 150                 155                 160 


Ser Val Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro 
                165                 170                 175     


Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser 
            180                 185                 190         


His Leu Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg 
        195                 200                 205             


Thr Gly Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys 
    210                 215                 220                 


Asn Cys Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln 
225                 230                 235                 240 


Arg Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp 
                245                 250                 255     


Ile Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
            260                 265                 


<210> 8462
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8462
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu 
            


<210> 8463
<211> 252
<212> PRT
<213> Homo sapiens

<400> 8463
Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Gly Tyr Arg Cys Pro Leu 
                165                 170                 175     


Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp Arg Gln Leu Asp 
            180                 185                 190         


Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr Gln Asn Met Thr 
        195                 200                 205             


Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser Thr Val Gln Phe 
    210                 215                 220                 


His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser Tyr Asn Thr Ala 
225                 230                 235                 240 


Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln 
                245                 250         


<210> 8464
<211> 197
<212> PRT
<213> Homo sapiens

<400> 8464
Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15      


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30          


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45              


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60                  


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80  


Glu Phe Met Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr 
                85                  90                  95      


Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys 
            100                 105                 110         


Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val 
        115                 120                 125             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp 
    130                 135                 140                 


Val Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp 
145                 150                 155                 160 


Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys 
                165                 170                 175     


Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys 
            180                 185                 190         


Leu Leu Thr Leu Asp 
        195         


<210> 8465
<211> 1400
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8465
Xaa Pro Pro Pro Pro Pro Pro Pro Met Trp Asn Pro Met Ile Pro Ala 
1               5                   10                  15      


Phe Asp Leu Phe Gln Gly Asn His Gly Phe Val Ala Pro Val Val Thr 
            20                  25                  30          


Thr Ala Ala His Trp Arg Ser Val Asn Tyr Thr Phe Pro Pro Ser Val 
        35                  40                  45              


Ile Ser His Thr Ser Pro Thr Lys Val Trp Arg Asn Lys Asp Gly Thr 
    50                  55                  60                  


Ser Ala Tyr Gln Val Gln Glu Thr Pro Val Ser Gln Val Val Arg Lys 
65                  70                  75                  80  


Lys Thr Ser Tyr Val Gly Leu Val Leu Val Leu Leu Arg Gly Leu Pro 
                85                  90                  95      


Gly Ser Gly Lys Ser Phe Leu Ala Arg Thr Leu Gln Glu Asp Asn Pro 
            100                 105                 110         


Ser Gly Val Ile Leu Ser Thr Asp Asp Tyr Phe Tyr Ile Asn Gly Gln 
        115                 120                 125             


Tyr Gln Phe Asp Val Lys Tyr Leu Gly Glu Ala His Glu Trp Asn Gln 
    130                 135                 140                 


Asn Arg Ala Lys Glu Ala Phe Glu Lys Lys Ile Ser Pro Ile Ile Ile 
145                 150                 155                 160 


Asp Asn Thr Asn Leu Gln Ala Trp Glu Met Lys Pro Tyr Val Ala Leu 
                165                 170                 175     


Ser Gln Lys His Lys Tyr Lys Val Leu Phe Arg Glu Pro Asp Thr Trp 
            180                 185                 190         


Trp Lys Phe Lys Pro Lys Glu Leu Ala Arg Arg Asn Ile His Gly Val 
        195                 200                 205             


Ser Lys Glu Lys Ile Thr Arg Met Leu Glu His Tyr Gln Arg Phe Val 
    210                 215                 220                 


Ser Val Pro Ile Ile Met Ser Ser Ser Val Pro Glu Lys Ile Glu Arg 
225                 230                 235                 240 


Ile Glu Leu Cys Ala Tyr Ser Cys Glu Asp Arg Ser Thr Ser Pro Arg 
                245                 250                 255     


Asp Asp Glu Asp Ile Ile Ser Glu Lys Glu Glu Asn Ile Leu Ser Leu 
            260                 265                 270         


Ser Leu Lys His Leu Glu Phe Thr Glu Glu Lys Asn Leu Asp Val Thr 
        275                 280                 285             


Lys Glu Thr Met Leu Pro Glu Asn Val Ala Tyr Leu Ser Asn Ala Asp 
    290                 295                 300                 


Leu Asn Lys Arg Arg Lys Glu Ile Ser Asp Met Asn Pro Ser Ile Gln 
305                 310                 315                 320 


Ser Ala Leu Ile Leu Glu Thr Pro His Met Tyr Phe Ser Asp Ser Glu 
                325                 330                 335     


Ser Lys Leu Gln Ala Thr Asp Lys Ser Glu Asn Glu Gln Ile Glu Met 
            340                 345                 350         


Val Ala Val Lys Gly Tyr Ser Lys Thr Asp Thr Asp Ser Ser Met Glu 
        355                 360                 365             


Arg Val Ser Pro Ser Thr Cys Cys Ser Glu Asn Asn Gln Glu Asp Cys 
    370                 375                 380                 


Asp Leu Ala Asn Ser Gly Pro Leu Gln Asn Glu Lys Ser Ser Pro Gly 
385                 390                 395                 400 


Glu Ile Val Glu Glu Arg Ala Thr Val Thr Lys Lys Ala Phe Gly Lys 
                405                 410                 415     


Gln Lys Ser Lys Ser Thr Leu Glu Lys Phe Pro Arg His Glu Leu Ser 
            420                 425                 430         


Asn Phe Val Gly Asp Trp Pro Val Asp Lys Thr Ile Gly Gln Arg Thr 
        435                 440                 445             


Lys Arg Asn Arg Lys Thr Glu Lys Thr Ser Ser Val Gln Ser Asp Lys 
    450                 455                 460                 


Lys Tyr Asn Tyr Pro Gln Ser His Lys Leu Val Asn Ser Val Ser Val 
465                 470                 475                 480 


Asn Thr Asp Cys Val Gln Gln Arg Gly Ser Pro His Glu Ser Val Glu 
                485                 490                 495     


Asp Gly Arg Lys Ser Gln Cys Asp Asp Ala Ser Glu Pro Leu Asn Ser 
            500                 505                 510         


Tyr Lys Tyr Asp Ala Tyr Lys Asn Ile Asp Lys Asn Ser Phe Asn Ile 
        515                 520                 525             


Met Gly Asp Trp Pro Ser Ser Asp Ser Leu Ala Gln Arg Glu His Arg 
    530                 535                 540                 


Ser Arg Met Pro Lys Thr Gly Leu Ser Glu Pro Asn Leu Glu Ile Gly 
545                 550                 555                 560 


Thr Asn Asp Lys Met Asn Glu Ile Ser Leu Ser Thr Ala His Glu Ala 
                565                 570                 575     


Cys Trp Gly Thr Ser Ser Gln Lys Leu Lys Thr Leu Gly Ser Ser Asn 
            580                 585                 590         


Leu Gly Ser Ser Glu Met Leu Leu Ser Glu Met Thr Cys Glu Ser Gln 
        595                 600                 605             


Thr Cys Leu Ser Lys Lys Ser His Gly Gln His Thr Ser Leu Pro Leu 
    610                 615                 620                 


Thr Phe Thr Asn Ser Ala Pro Thr Val Ser Gly Val Val Glu Pro Gln 
625                 630                 635                 640 


Thr Leu Ala Glu Cys Gln Glu Gln Met Pro Lys Arg Asp Pro Gly Lys 
                645                 650                 655     


Glu Val Gly Met Cys Thr Gln Thr Glu Pro Gln Asp Phe Ala Leu Leu 
            660                 665                 670         


Trp Lys Ile Glu Lys Asn Lys Ile Ser Ile Ser Asp Ser Ile Lys Val 
        675                 680                 685             


Leu Thr Gly Arg Leu Asp Gly Phe Lys Pro Lys Val Phe Asn Ile Asn 
    690                 695                 700                 


Thr Lys Ser Asp Val Gln Glu Ala Ile Pro Tyr Arg Val Met Tyr Asp 
705                 710                 715                 720 


Lys Ser Thr Phe Val Glu Glu Ser Glu Leu Thr Ser Ala Asp Glu Ser 
                725                 730                 735     


Glu Asn Leu Asn Ile Leu Cys Lys Leu Phe Gly Ser Phe Ser Leu Glu 
            740                 745                 750         


Ala Leu Lys Asp Leu Tyr Glu Arg Cys Asn Lys Asp Ile Ile Trp Ala 
        755                 760                 765             


Thr Ser Leu Leu Leu Asp Ser Glu Thr Lys Leu Cys Glu Asp Thr Glu 
    770                 775                 780                 


Phe Glu Asn Phe Gln Lys Ser Cys Asp Gly Ser Gln Ile Gly Pro Phe 
785                 790                 795                 800 


Ser Leu Gly Leu Asn Leu Lys Glu Ile Ile Ser Gln Arg Gly Thr Leu 
                805                 810                 815     


Glu Asn Ser Asn Ser Pro Val Pro Glu Phe Ser His Gly Ile Gly Ile 
            820                 825                 830         


Ser Asn Ala Asp Ser Gln Ser Thr Cys Asp Ala Glu Arg Gly Asn Ser 
        835                 840                 845             


Glu Gln Ala Glu Met Arg Ala Val Thr Pro Glu Asn His Glu Ser Met 
    850                 855                 860                 


Thr Ser Ile Phe Pro Ser Ala Ala Val Gly Leu Lys Asn Asn Asn Asp 
865                 870                 875                 880 


Ile Leu Pro Asn Ser Gln Glu Glu Leu Leu Tyr Ser Ser Lys Gln Ser 
                885                 890                 895     


Phe Pro Gly Ile Leu Lys Ala Thr Thr Pro Lys Asp Met Ser Glu Thr 
            900                 905                 910         


Glu Lys Asn Leu Val Val Thr Glu Thr Gly Asp Asn Ile His Ser Pro 
        915                 920                 925             


Ser His Phe Ser Asp Ile Phe Asn Phe Val Ser Ser Thr Ser Asn Leu 
    930                 935                 940                 


Glu Leu Asn Glu Glu Ile Tyr Phe Thr Asp Ser Leu Glu Ile Lys Arg 
945                 950                 955                 960 


Asn Glu Asn Phe Pro Lys Asp Tyr Val Lys Phe Ser Asp Glu Glu Glu 
                965                 970                 975     


Phe Met Asn Glu Asp Glu Lys Glu Met Lys Glu Ile Leu Met Ala Gly 
            980                 985                 990         


Ser Ser Leu Ser Ala Gly Val Ser  Gly Glu Asp Lys Thr  Glu Ile Leu 
        995                 1000                 1005             


Asn Pro  Thr Pro Ala Met Ala  Lys Ser Leu Thr Ile  Asp Cys Leu 
    1010                 1015                 1020             


Glu Leu  Ala Leu Pro Pro Glu  Leu Ala Phe Gln Leu  Asn Glu Leu 
    1025                 1030                 1035             


Phe Gly  Pro Val Gly Ile Asp  Ser Gly Ser Leu Thr  Val Glu Asp 
    1040                 1045                 1050             


Cys Val  Val His Ile Asp Leu  Asn Leu Ala Lys Val  Ile His Glu 
    1055                 1060                 1065             


Lys Trp  Lys Glu Ser Val Met  Glu Arg Gln Arg Gln  Glu Glu Val 
    1070                 1075                 1080             


Ser Cys  Gly Lys Phe Met Gln  Asp Pro Ser Leu Val  Gly His Thr 
    1085                 1090                 1095             


Gly Leu  Asp Asn Pro Glu Gln  Lys Ser Ser Gln Arg  Thr Gly Lys 
    1100                 1105                 1110             


Lys Leu  Leu Lys Thr Leu Thr  Ala Ser Glu Met Leu  Pro Leu Leu 
    1115                 1120                 1125             


Asp His  Trp Asn Thr Gln Thr  Lys Lys Val Ser Leu  Arg Glu Ile 
    1130                 1135                 1140             


Met Ser  Glu Glu Ile Ala Leu  Gln Glu Lys His Asn  Leu Lys Arg 
    1145                 1150                 1155             


Glu Thr  Leu Met Phe Glu Lys  Asp Cys Ala Thr Lys  Leu Lys Glu 
    1160                 1165                 1170             


Lys Gln  Leu Phe Lys Ile Phe  Pro Ala Ile Asn Gln  Asn Phe Leu 
    1175                 1180                 1185             


Val Asp  Ile Phe Lys Asp His  Asn Tyr Ser Leu Glu  His Thr Val 
    1190                 1195                 1200             


Gln Phe  Leu Asn Cys Val Leu  Glu Gly Asp Pro Val  Lys Thr Val 
    1205                 1210                 1215             


Val Ala  Gln Glu Phe Val His  Gln Asn Glu Asn Val  Thr Ser His 
    1220                 1225                 1230             


Thr Gly  Gln Lys Ser Lys Glu  Lys Lys Asp Phe Glu  Tyr Pro Asp 
    1235                 1240                 1245             


Tyr Asp  Asp Tyr Arg Ala Glu  Ala Phe Leu His Gln  Gln Lys Arg 
    1250                 1255                 1260             


Met Glu  Cys Tyr Ser Lys Ala  Lys Glu Ala Tyr Arg  Ile Gly Lys 
    1265                 1270                 1275             


Lys Asn  Val Ala Thr Phe Tyr  Ala Gln Gln Gly Thr  Leu His Glu 
    1280                 1285                 1290             


Gln Lys  Met Lys Glu Ala Asn  His Leu Ala Ala Ile  Glu Ile Phe 
    1295                 1300                 1305             


Glu Lys  Val Asn Ala Ser Leu  Leu Pro Gln Asn Val  Leu Asp Leu 
    1310                 1315                 1320             


His Gly  Leu His Val Asp Glu  Ala Leu Glu His Leu  Met Arg Val 
    1325                 1330                 1335             


Leu Glu  Lys Lys Thr Glu Glu  Phe Lys Gln Asn Gly  Gly Lys Pro 
    1340                 1345                 1350             


Tyr Leu  Ser Val Ile Thr Gly  Arg Gly Asn His Ser  Gln Gly Gly 
    1355                 1360                 1365             


Val Ala  Arg Ile Lys Pro Ala  Val Ile Lys Tyr Leu  Ile Ser His 
    1370                 1375                 1380             


Ser Phe  Arg Phe Ser Glu Ile  Lys Pro Gly Cys Leu  Lys Val Met 
    1385                 1390                 1395             


Leu Lys  
    1400 


<210> 8466
<211> 78
<212> PRT
<213> Homo sapiens

<400> 8466
Met Leu Cys Trp Gly Tyr Trp Ser Leu Gly Gln Pro Gly Ile Ser Thr 
1               5                   10                  15      


Asn Leu Gln Gly Ile Val Ala Glu Pro Gln Val Cys Gly Phe Ile Ser 
            20                  25                  30          


Asp Arg Ser Val Lys Glu Val Ala Cys Gly Gly Asn His Ser Val Phe 
        35                  40                  45              


Leu Leu Glu Asp Gly Glu Val Tyr Thr Cys Gly Leu Asn Thr Lys Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Arg Glu Gly Asn Lys Pro Glu Gln Ile 
65                  70                  75              


<210> 8467
<211> 245
<212> PRT
<213> Homo sapiens

<400> 8467
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 
            180                 185                 190         


Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 
        195                 200                 205             


Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 
    210                 215                 220                 


Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 
225                 230                 235                 240 


Asp Thr Trp Asp Glu 
                245 


<210> 8468
<211> 703
<212> PRT
<213> Homo sapiens

<400> 8468
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Thr Met Arg Val Asn Asp Leu Val Gly Thr 
225                 230                 235                 240 


Ser Met Thr Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Thr Asn Thr Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Arg Pro Arg Glu Glu Ser Leu Ala Glu Lys Lys 
305                 310                 315                 320 


Tyr Thr Ser Gln Gly Gln Gly Asp Leu Asp Ser Val Leu Ser Gln Leu 
                325                 330                 335     


Asn Phe Thr His Thr Ser Glu Asp Leu Leu Gln Ala Glu Val Thr Cys 
            340                 345                 350         


Leu Glu Gly Ser Leu Glu Ser Val Ser Ala Thr Cys Lys Gln Leu Ser 
        355                 360                 365             


Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu Ala His 
    370                 375                 380                 


Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln Ile Leu 
385                 390                 395                 400 


Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys Met Glu 
                405                 410                 415     


Ile Ser His Leu Thr Gln Glu Leu His Gln Arg Asp Ile Thr Ile Ala 
            420                 425                 430         


Ser Thr Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg Ala Glu 
        435                 440                 445             


Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile Leu Asp 
    450                 455                 460                 


Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu Met Val 
465                 470                 475                 480 


Met Lys Leu Glu Leu Gly Leu His Glu Ala Lys Glu Ile Ser Leu Ala 
                485                 490                 495     


Asp Leu Gln Glu Asn Tyr Ile Glu Ala Leu Asn Lys Leu Val Ser Glu 
            500                 505                 510         


Asn Gln Gln Leu Gln Lys Asp Leu Met Asn Thr Lys Ser Gln Leu Glu 
        515                 520                 525             


Ile Ser Thr Gln Met Cys Lys Lys Gln Asn Asp Arg Ile Phe Lys Pro 
    530                 535                 540                 


Thr His Ser Arg Thr Thr Glu Phe Lys Asn Thr Glu Phe Lys Pro Thr 
545                 550                 555                 560 


His Gly Gln His Arg His Asp Gly Ile Lys Thr Glu His Tyr Lys Thr 
                565                 570                 575     


Asp Leu His Ser Pro Arg Gly Gln Ala Ser Asp Ser Ile Asn Pro Met 
            580                 585                 590         


Ser Arg Val Leu Ser Pro Leu Ser Pro Gln Ile Ser Pro Cys Ser Ser 
        595                 600                 605             


Thr Arg Ser Leu Thr Ser Tyr Ser Leu Cys Lys Thr His Ser Leu Pro 
    610                 615                 620                 


Ser Ala Leu Asp Thr Asn Glu Ala Asn Phe Ser Asp Thr Met Ser Glu 
625                 630                 635                 640 


Ser Met Asn Asp Gln Glu Glu Phe Ile Ser Ser Cys Ser Leu Pro Val 
                645                 650                 655     


Ser Pro Leu Gly Ser Ile Ala Thr Arg Phe Leu Glu Glu Glu Glu Leu 
            660                 665                 670         


Arg Ser His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu 
        675                 680                 685             


Lys Arg Glu Ser Glu Lys Thr Val Arg Gln Phe Thr Ala Leu Lys 
    690                 695                 700             


<210> 8469
<211> 190
<212> PRT
<213> Homo sapiens

<400> 8469
Met Ala Gly Thr Ala Arg His Asp Arg Glu Met Ala Ile Gln Ala Lys 
1               5                   10                  15      


Lys Lys Leu Thr Thr Ala Thr Asp Pro Ile Glu Arg Leu Arg Leu Gln 
            20                  25                  30          


Cys Leu Ala Arg Gly Ser Ala Gly Ile Lys Gly Leu Gly Arg Val Phe 
        35                  40                  45              


Arg Ile Met Asp Asp Asp Asn Asn Arg Thr Leu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Met Lys Gly Leu Asn Asp Tyr Ala Val Val Met Glu Lys Glu Glu Val 
65                  70                  75                  80  


Glu Glu Leu Phe Arg Arg Phe Asp Lys Asp Gly Asn Gly Thr Ile Asp 
                85                  90                  95      


Phe Asn Glu Phe Leu Leu Thr Leu Arg Pro Pro Met Ser Arg Ala Arg 
            100                 105                 110         


Lys Glu Val Ile Met Gln Ala Phe Arg Lys Leu Asp Lys Thr Gly Asp 
        115                 120                 125             


Gly Val Ile Thr Ile Glu Asp Leu Arg Glu Val Tyr Asn Ala Lys His 
    130                 135                 140                 


His Pro Lys Tyr Gln Asn Gly Glu Trp Ser Glu Glu Gln Val Phe Arg 
145                 150                 155                 160 


Lys Phe Leu Asp Asn Phe Asp Ser Pro Tyr Asp Lys Asp Gly Leu Val 
                165                 170                 175     


Thr Pro Glu Glu Phe Met Asn Tyr Tyr Ala Gly Val Ser Ala 
            180                 185                 190 


<210> 8470
<211> 76
<212> PRT
<213> Homo sapiens

<400> 8470
Met Thr Pro Pro Gln Gln Pro Pro Pro Leu Arg Ser Glu Pro Gly Thr 
1               5                   10                  15      


Leu Gly Ser Ala Ala Ser Ser Tyr Ser Pro Leu Gly Leu Asn Gly Val 
            20                  25                  30          


Pro Gly Ser Ile Trp Asp Phe Val Ser Gly Ser Phe Ser Pro Ser Pro 
        35                  40                  45              


Ser Pro Ile Leu Ser Ala Gly Pro Pro Ser Ser Ser Ser Ala Ser Pro 
    50                  55                  60                  


Asn Gly Ala Glu Leu Ala Arg Val Arg Arg Gln Leu 
65                  70                  75      


<210> 8471
<211> 35
<212> PRT
<213> Homo sapiens

<400> 8471
Met Ala Thr Leu Val Val Asn Lys Leu Gly Ala Gly Val Asp Ser Gly 
1               5                   10                  15      


Arg Gln Gly Ser Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly 
            20                  25                  30          


Val Cys Glu 
        35  


<210> 8472
<211> 158
<212> PRT
<213> Homo sapiens

<400> 8472
Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys Met His Leu Glu Lys Leu Glu Glu 
                85                  90                  95      


Gln Leu Ser Arg Ser His Gly Gln Glu Val Asn Glu Leu Lys Thr Lys 
            100                 105                 110         


Ile Glu Lys Leu Lys Val Glu Leu Asp Glu Ala Arg Leu Ser Glu Lys 
        115                 120                 125             


Gln Leu Lys His Gln Val Asp His Gln Lys Glu Leu Leu Ser Cys Lys 
    130                 135                 140                 


Ser Glu Glu Leu Arg Val Met Ser Glu Arg Val Gln Glu Ser 
145                 150                 155             


<210> 8473
<211> 130
<212> PRT
<213> Homo sapiens

<400> 8473
Met Ala Gln Thr Asp Lys Pro Thr Cys Ile Pro Pro Glu Leu Pro Lys 
1               5                   10                  15      


Met Leu Lys Glu Phe Ala Lys Ala Ala Ile Arg Ala Gln Pro Gln Asp 
            20                  25                  30          


Leu Ile Gln Trp Gly Ala Asp Tyr Phe Glu Ala Leu Ser Arg Gly Glu 
        35                  40                  45              


Thr Pro Pro Val Arg Glu Arg Ser Glu Arg Val Ala Leu Cys Asn Trp 
    50                  55                  60                  


Ala Glu Leu Thr Pro Glu Leu Leu Lys Ile Leu His Ser Gln Val Ala 
65                  70                  75                  80  


Gly Arg Leu Ile Ile Arg Ala Glu Glu Leu Ala Gln Met Trp Lys Val 
                85                  90                  95      


Val Asn Leu Pro Thr Asp Leu Phe Asn Ser Val Met Asn Val Gly Arg 
            100                 105                 110         


Phe Thr Glu Glu Ile Glu Trp Leu Lys Phe Leu Ala Leu Ala Cys Ser 
        115                 120                 125             


Ala Leu 
    130 


<210> 8474
<211> 230
<212> PRT
<213> Homo sapiens

<400> 8474
Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys Met His Leu Glu Lys Leu Glu Glu 
                85                  90                  95      


Gln Leu Ser Arg Ser His Gly Gln Glu Val Asn Glu Leu Lys Thr Lys 
            100                 105                 110         


Ile Glu Lys Leu Lys Val Glu Leu Asp Glu Ala Arg Leu Ser Glu Lys 
        115                 120                 125             


Gln Leu Lys His Gln Val Asp His Gln Lys Glu Leu Leu Ser Cys Lys 
    130                 135                 140                 


Ser Glu Glu Leu Arg Val Met Ser Glu Arg Val Gln Glu Ser Met Ser 
145                 150                 155                 160 


Ser Glu Met Leu Ala Leu Gln Ile Glu Leu Thr Glu Met Glu Ser Met 
                165                 170                 175     


Lys Thr Thr Leu Lys Glu Glu Val Asn Glu Leu Gln Tyr Arg Gln Glu 
            180                 185                 190         


Gln Leu Glu Leu Leu Ile Thr Asn Leu Met Arg Gln Val Asp Arg Leu 
        195                 200                 205             


Lys Glu Glu Lys Glu Glu Arg Glu Lys Glu Ala Val Ser Tyr Tyr Asn 
    210                 215                 220                 


Ala Leu Glu Lys Ala Arg 
225                 230 


<210> 8475
<211> 212
<212> PRT
<213> Homo sapiens

<400> 8475
Met Ala Gln Thr Asp Lys Pro Thr Cys Ile Pro Pro Glu Leu Pro Lys 
1               5                   10                  15      


Met Leu Lys Glu Phe Ala Lys Ala Ala Ile Arg Ala Gln Pro Gln Asp 
            20                  25                  30          


Leu Ile Gln Trp Gly Ala Asp Tyr Phe Glu Ala Leu Ser Arg Gly Glu 
        35                  40                  45              


Thr Pro Pro Val Arg Glu Arg Ser Glu Arg Val Ala Leu Cys Asn Trp 
    50                  55                  60                  


Ala Glu Leu Thr Pro Glu Leu Leu Lys Ile Leu His Ser Gln Val Ala 
65                  70                  75                  80  


Gly Arg Leu Ile Ile Arg Ala Glu Glu Leu Ala Gln Met Trp Lys Val 
                85                  90                  95      


Val Asn Leu Pro Thr Asp Leu Phe Asn Ser Val Met Asn Val Gly Arg 
            100                 105                 110         


Phe Thr Glu Glu Ile Glu Trp Leu Lys Phe Leu Ala Leu Ala Cys Ser 
        115                 120                 125             


Ala Leu Gly Val Thr Ile Thr Lys Thr Leu Lys Ile Val Cys Glu Val 
    130                 135                 140                 


Leu Ser Cys Asp His Asn Gly Gly Leu Pro Arg Ile Pro Phe Ser Thr 
145                 150                 155                 160 


Phe Gln Phe Leu Tyr Thr Tyr Ile Ala Glu Val Asp Gly Glu Ile Cys 
                165                 170                 175     


Ala Ser His Val Ser Arg Met Leu Asn Tyr Ile Glu Gln Glu Val Ile 
            180                 185                 190         


Gly Pro Asp Gly Leu Ile Thr Val Asn Asp Phe Thr Gln Asn Pro Arg 
        195                 200                 205             


Val Trp Leu Glu 
    210         


<210> 8476
<211> 947
<212> PRT
<213> Homo sapiens

<400> 8476
Met Asn Phe Leu Arg Gly Val Met Gly Gly Gln Ser Ala Gly Pro Gln 
1               5                   10                  15      


His Thr Glu Ala Glu Thr Val Arg Gly Ala Ala Asp Pro Lys Val Thr 
            20                  25                  30          


Ser Ser Cys Gly Leu Lys Phe Arg His Ser Phe Arg Leu Val Lys His 
        35                  40                  45              


Ile Leu Tyr His Val Thr Ile Asn Val Tyr Ser Asp Ser Glu Ile Ile 
    50                  55                  60                  


Gly Tyr Ala Leu Asp Thr Leu Tyr Asn Ile Ile Ser Asn Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Val Glu Glu Asn Ser Thr Arg Gln Ser Glu Asp Leu Gly Ser 
                85                  90                  95      


Gln Phe Thr Glu Ile Phe Ile Lys Gln Gln Glu Asn Val Thr Leu Leu 
            100                 105                 110         


Leu Ser Leu Leu Glu Glu Phe Asp Phe His Val Arg Trp Pro Gly Val 
        115                 120                 125             


Lys Leu Leu Thr Ser Leu Leu Lys Gln Leu Gly Pro Gln Val Gln Gln 
    130                 135                 140                 


Ile Ile Leu Val Ser Pro Met Gly Val Ser Arg Leu Met Asp Leu Leu 
145                 150                 155                 160 


Ala Asp Ser Arg Glu Val Ile Arg Asn Asp Gly Val Leu Leu Leu Gln 
                165                 170                 175     


Ala Leu Thr Arg Ser Asn Gly Ala Ile Gln Lys Ile Val Ala Phe Glu 
            180                 185                 190         


Asn Ala Phe Glu Arg Leu Leu Asp Ile Ile Ser Glu Glu Gly Asn Ser 
        195                 200                 205             


Asp Gly Gly Ile Val Val Glu Asp Cys Leu Ile Leu Leu Gln Asn Leu 
    210                 215                 220                 


Leu Lys Asn Asn Asn Ser Asn Gln Asn Phe Phe Lys Glu Gly Ser Tyr 
225                 230                 235                 240 


Ile Gln Arg Met Lys Pro Trp Phe Glu Val Gly Asp Glu Asn Ser Gly 
                245                 250                 255     


Trp Ser Ala Gln Lys Val Thr Asn Leu His Leu Met Leu Gln Leu Val 
            260                 265                 270         


Arg Val Leu Val Ser Pro Thr Asn Pro Pro Gly Ala Thr Ser Ser Cys 
        275                 280                 285             


Gln Lys Ala Met Phe Gln Cys Gly Leu Leu Gln Gln Leu Cys Thr Ile 
    290                 295                 300                 


Leu Met Ala Thr Gly Val Pro Ala Asp Ile Leu Thr Glu Thr Ile Asn 
305                 310                 315                 320 


Thr Val Ser Glu Val Ile Arg Gly Cys Gln Val Asn Gln Asp Tyr Phe 
                325                 330                 335     


Ala Ser Val Asn Ala Pro Ser Asn Pro Pro Arg Pro Ala Ile Val Val 
            340                 345                 350         


Leu Leu Met Ser Met Val Asn Glu Arg Gln Pro Phe Val Leu Arg Cys 
        355                 360                 365             


Ala Val Leu Tyr Cys Phe Gln Cys Phe Leu Tyr Lys Asn Gln Lys Gly 
    370                 375                 380                 


Gln Gly Glu Ile Val Ser Thr Leu Leu Pro Ser Thr Ile Asp Ala Thr 
385                 390                 395                 400 


Gly Asn Ser Val Ser Ala Gly Gln Leu Leu Cys Gly Gly Leu Phe Ser 
                405                 410                 415     


Thr Asp Ser Leu Ser Asn Trp Cys Ala Ala Val Ala Leu Ala His Ala 
            420                 425                 430         


Leu Gln Glu Asn Ala Thr Gln Lys Glu Gln Leu Leu Arg Val Gln Leu 
        435                 440                 445             


Ala Thr Ser Ile Gly Asn Pro Pro Val Ser Leu Leu Gln Gln Cys Thr 
    450                 455                 460                 


Asn Ile Leu Ser Gln Gly Ser Lys Ile Gln Thr Arg Val Gly Leu Leu 
465                 470                 475                 480 


Met Leu Leu Cys Thr Trp Leu Ser Asn Cys Pro Ile Ala Val Thr His 
                485                 490                 495     


Phe Leu His Asn Ser Ala Asn Val Pro Phe Leu Thr Gly Gln Ile Ala 
            500                 505                 510         


Glu Asn Leu Gly Glu Glu Glu Gln Leu Val Gln Gly Leu Cys Ala Leu 
        515                 520                 525             


Leu Leu Gly Ile Ser Ile Tyr Phe Asn Asp Asn Ser Leu Glu Ser Tyr 
    530                 535                 540                 


Met Lys Glu Lys Leu Lys Gln Leu Ile Glu Lys Arg Ile Gly Lys Glu 
545                 550                 555                 560 


Asn Phe Ile Glu Lys Leu Gly Phe Ile Ser Lys His Glu Leu Tyr Ser 
                565                 570                 575     


Arg Ala Ser Gln Lys Pro Gln Pro Asn Phe Pro Ser Pro Glu Tyr Met 
            580                 585                 590         


Ile Phe Asp His Glu Phe Thr Lys Leu Val Lys Glu Leu Glu Gly Val 
        595                 600                 605             


Ile Thr Lys Ala Ile Tyr Lys Ser Ser Glu Glu Asp Lys Lys Glu Glu 
    610                 615                 620                 


Glu Val Lys Lys Thr Leu Glu Gln His Asp Asn Ile Val Thr His Tyr 
625                 630                 635                 640 


Lys Asn Met Ile Arg Glu Gln Asp Leu Gln Leu Glu Glu Leu Arg Gln 
                645                 650                 655     


Gln Val Ser Thr Leu Lys Cys Gln Asn Glu Gln Leu Gln Thr Ala Val 
            660                 665                 670         


Thr Gln Gln Val Ser Gln Ile Gln Gln His Lys Asp Gln Tyr Asn Leu 
        675                 680                 685             


Leu Lys Ile Gln Leu Gly Lys Asp Asn Gln His Gln Gly Ser Tyr Ser 
    690                 695                 700                 


Glu Gly Ala Gln Met Asn Gly Ile Gln Pro Glu Glu Ile Gly Arg Leu 
705                 710                 715                 720 


Arg Glu Glu Ile Glu Glu Leu Lys Arg Asn Gln Glu Leu Leu Gln Ser 
                725                 730                 735     


Gln Leu Thr Glu Lys Asp Ser Met Ile Glu Asn Met Lys Ser Ser Gln 
            740                 745                 750         


Thr Ser Gly Thr Asn Glu Gln Ser Ser Ala Ile Val Ser Ala Arg Asp 
        755                 760                 765             


Ser Glu Gln Val Ala Glu Leu Lys Gln Glu Leu Ala Thr Leu Lys Ser 
    770                 775                 780                 


Gln Leu Asn Ser Gln Ser Val Glu Ile Thr Lys Leu Gln Thr Glu Lys 
785                 790                 795                 800 


Gln Glu Leu Leu Gln Lys Thr Glu Ala Phe Ala Lys Ser Val Glu Val 
                805                 810                 815     


Gln Gly Glu Thr Glu Thr Ile Ile Ala Thr Lys Thr Thr Asp Val Glu 
            820                 825                 830         


Gly Arg Leu Ser Ala Leu Leu Gln Glu Thr Lys Glu Leu Lys Asn Glu 
        835                 840                 845             


Ile Lys Ala Leu Ser Glu Glu Arg Thr Ala Ile Lys Glu Gln Leu Asp 
    850                 855                 860                 


Ser Ser Asn Ser Thr Ile Ala Ile Leu Gln Thr Glu Lys Asp Lys Leu 
865                 870                 875                 880 


Glu Leu Glu Ile Thr Asp Ser Lys Lys Glu Gln Asp Asp Leu Leu Val 
                885                 890                 895     


Leu Leu Ala Asp Gln Asp Gln Lys Ile Leu Ser Leu Lys Asn Lys Leu 
            900                 905                 910         


Lys Asp Leu Gly His Pro Val Glu Glu Glu Asp Glu Leu Glu Ser Gly 
        915                 920                 925             


Asp Gln Glu Asp Glu Asp Asp Glu Ser Glu Asp Pro Gly Lys Asp Leu 
    930                 935                 940                 


Asp His Ile 
945         


<210> 8477
<211> 364
<212> PRT
<213> Homo sapiens

<400> 8477
Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Lys Arg Met His Val Gln 
    130                 135                 140                 


Leu Ser Thr Ser Arg Leu Arg Thr Ala Pro Gly Met Gly Asp Gln Ser 
145                 150                 155                 160 


Gly Cys Tyr Arg Cys Gly Lys Glu Gly His Trp Ser Lys Glu Cys Pro 
                165                 170                 175     


Ile Asp Arg Ser Gly Arg Val Ala Asp Leu Thr Glu Gln Tyr Asn Glu 
            180                 185                 190         


Gln Tyr Gly Ala Val Arg Thr Pro Tyr Thr Met Ser Tyr Gly Asp Ser 
        195                 200                 205             


Leu Tyr Tyr Asn Asn Ala Tyr Gly Ala Leu Asp Ala Tyr Tyr Lys Arg 
    210                 215                 220                 


Cys Arg Ala Ala Arg Ser Tyr Glu Ala Val Ala Ala Ala Ala Ala Ser 
225                 230                 235                 240 


Val Tyr Asn Tyr Ala Glu Gln Thr Leu Ser Gln Leu Pro Gln Val Gln 
                245                 250                 255     


Asn Thr Ala Met Ala Ser His Leu Thr Ser Thr Ser Leu Asp Pro Tyr 
            260                 265                 270         


Asp Arg His Leu Leu Pro Thr Ser Gly Ala Ala Ala Thr Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Val Thr Ala Ala Ser Thr Ser Tyr Tyr 
    290                 295                 300                 


Gly Arg Asp Arg Ser Pro Leu Arg Arg Ala Thr Ala Pro Val Pro Thr 
305                 310                 315                 320 


Val Gly Glu Gly Tyr Gly Tyr Gly His Glu Ser Glu Leu Ser Gln Ala 
                325                 330                 335     


Ser Ala Ala Ala Arg Asn Ser Leu Tyr Asp Met Ala Arg Tyr Glu Arg 
            340                 345                 350         


Glu Gln Tyr Ala Asp Arg Ala Arg Tyr Ser Ala Phe 
        355                 360                 


<210> 8478
<211> 411
<212> PRT
<213> Homo sapiens

<400> 8478
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110         


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125             


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140                 


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys 
145                 150                 155                 160 


Asn Leu Pro Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu 
                165                 170                 175     


Lys Asn Arg Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro 
            180                 185                 190         


Leu Gly Lys Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val 
        195                 200                 205             


Asn Cys Gly Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu 
    210                 215                 220                 


Ser Thr Ile Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn 
225                 230                 235                 240 


Val Ile Ala Met Ile Thr Arg Glu Ile Glu Gly Gly Ile Ile Lys Cys 
                245                 250                 255     


Tyr His Tyr Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His 
            260                 265                 270         


Phe Arg Val Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile 
        275                 280                 285             


Arg Met Phe Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val 
    290                 295                 300                 


Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser 
305                 310                 315                 320 


Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu 
                325                 330                 335     


Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly 
            340                 345                 350         


Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys 
        355                 360                 365             


Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser 
    370                 375                 380                 


Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val 
385                 390                 395                 400 


Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
                405                 410     


<210> 8479
<211> 269
<212> PRT
<213> Homo sapiens

<400> 8479
Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15      


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30          


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45              


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80  


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95      


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110         


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125             


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140                 


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Thr Gly Thr Ser His 
145                 150                 155                 160 


Ser Val Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro 
                165                 170                 175     


Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser 
            180                 185                 190         


His Leu Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg 
        195                 200                 205             


Thr Gly Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys 
    210                 215                 220                 


Asn Cys Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln 
225                 230                 235                 240 


Arg Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp 
                245                 250                 255     


Ile Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
            260                 265                 


<210> 8480
<211> 119
<212> PRT
<213> Homo sapiens

<400> 8480
Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu Thr His Arg Ser Asn Val 
            100                 105                 110         


Ser Leu Leu Glu Pro Tyr Gln 
        115                 


<210> 8481
<211> 112
<212> PRT
<213> Homo sapiens

<400> 8481
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


<210> 8482
<211> 17
<212> PRT
<213> Homo sapiens

<400> 8482
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly 
    


<210> 8483
<211> 269
<212> PRT
<213> Homo sapiens

<400> 8483
Met Asn Gln Glu Asp Leu Asp Pro Asp Ser Thr Thr Asp Val Gly Asp 
1               5                   10                  15      


Val Thr Asn Thr Glu Glu Glu Leu Ile Arg Glu Cys Glu Glu Met Trp 
            20                  25                  30          


Lys Asp Met Glu Glu Cys Gln Asn Lys Leu Ser Leu Ile Gly Thr Glu 
        35                  40                  45              


Thr Leu Thr Asp Ser Asn Ala Gln Leu Ser Leu Leu Ile Met Gln Val 
    50                  55                  60                  


Lys Cys Leu Thr Ala Glu Leu Ser Gln Trp Gln Lys Lys Thr Pro Glu 
65                  70                  75                  80  


Thr Ile Pro Leu Thr Glu Asp Val Leu Ile Thr Leu Gly Lys Glu Glu 
                85                  90                  95      


Phe Gln Lys Leu Arg Gln Asp Leu Glu Met Val Leu Ser Thr Lys Glu 
            100                 105                 110         


Ser Lys Asn Glu Lys Leu Lys Glu Asp Leu Glu Arg Glu Gln Arg Trp 
        115                 120                 125             


Leu Asp Glu Gln Gln Gln Ile Met Glu Ser Leu Asn Val Leu His Ser 
    130                 135                 140                 


Glu Leu Lys Asn Lys Val Glu Thr Phe Ser Glu Ser Arg Ile Phe Asn 
145                 150                 155                 160 


Glu Leu Lys Thr Lys Met Leu Asn Ile Lys Glu Tyr Lys Glu Lys Leu 
                165                 170                 175     


Leu Ser Thr Leu Gly Glu Phe Leu Glu Asp His Phe Pro Leu Pro Asp 
            180                 185                 190         


Arg Ser Val Lys Lys Lys Lys Lys Asn Ile Gln Glu Ser Ser Val Asn 
        195                 200                 205             


Leu Ile Thr Leu His Glu Met Leu Glu Ile Leu Ile Asn Arg Leu Phe 
    210                 215                 220                 


Asp Val Pro His Asp Pro Tyr Val Lys Ile Ser Asp Ser Phe Trp Pro 
225                 230                 235                 240 


Pro Tyr Val Glu Leu Leu Leu Arg Asn Gly Ile Ala Leu Arg His Pro 
                245                 250                 255     


Glu Asp Pro Thr Arg Ile Arg Leu Glu Ala Phe His Gln 
            260                 265                 


<210> 8484
<211> 112
<212> PRT
<213> Homo sapiens

<400> 8484
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


<210> 8485
<211> 228
<212> PRT
<213> Homo sapiens

<400> 8485
Met Glu Glu Gln Pro Gln Met Gln Asp Ala Asp Glu Pro Ala Asp Ser 
1               5                   10                  15      


Gly Gly Glu Gly Arg Ala Gly Gly Pro Pro Gln Val Ala Gly Ala Gln 
            20                  25                  30          


Ala Ala Cys Ser Glu Asp Arg Met Thr Leu Leu Leu Arg Leu Arg Ala 
        35                  40                  45              


Gln Thr Lys Gln Gln Leu Leu Glu Tyr Lys Ser Met Val Asp Ala Ser 
    50                  55                  60                  


Glu Glu Lys Thr Pro Glu Gln Ile Met Gln Glu Lys Gln Ile Glu Ala 
65                  70                  75                  80  


Lys Ile Glu Asp Leu Glu Asn Glu Ile Glu Glu Val Lys Val Ala Phe 
                85                  90                  95      


Glu Ile Lys Lys Leu Ala Leu Asp Ser Val Leu Met Asp Asn Met Lys 
            100                 105                 110         


His Leu Leu Glu Leu Asn Lys Leu Ile Met Lys Ser Gln Gln Glu Ser 
        115                 120                 125             


Trp Asp Leu Glu Glu Lys Leu Leu Asp Ile Arg Lys Lys Arg Leu Gln 
    130                 135                 140                 


Leu Lys Gln Ala Ser Glu Ser Lys Leu Leu Glu Ile Gln Thr Glu Lys 
145                 150                 155                 160 


Asn Lys Gln Lys Ile Asp Leu Asp Ser Met Glu Asn Ser Glu Arg Ile 
                165                 170                 175     


Lys Ile Ile Arg Gln Asn Leu Gln Met Glu Ile Lys Ile Thr Thr Val 
            180                 185                 190         


Ile Gln His Val Phe Gln Asn Leu Ile Leu Gly Ser Lys Val Asn Trp 
        195                 200                 205             


Ala Glu Asp Pro Ala Leu Lys Glu Ile Val Leu Gln Leu Glu Lys Asn 
    210                 215                 220                 


Val Asp Met Met 
225             


<210> 8486
<211> 783
<212> PRT
<213> Homo sapiens

<400> 8486
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala 
        435                 440                 445             


Gly Asn Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Phe Pro Ala Pro 
625                 630                 635                 640 


Pro Lys Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr 
                645                 650                 655     


Ser Asp Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val 
            660                 665                 670         


Gly Lys Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln 
        675                 680                 685             


Glu Lys Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly Glu 
    690                 695                 700                 


Ile Arg Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile Thr Ser Lys 
705                 710                 715                 720 


Lys Trp Gly Thr Arg Asp Leu Gln Val Lys Pro Gly Glu Ser Leu Glu 
                725                 730                 735     


Val Ile Gln Thr Thr Asp Asp Thr Lys Val Leu Cys Arg Asn Glu Glu 
            740                 745                 750         


Gly Lys Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly 
        755                 760                 765             


Glu Ile Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp 
    770                 775                 780             


<210> 8487
<211> 130
<212> PRT
<213> Homo sapiens

<400> 8487
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe 
    130 


<210> 8488
<211> 88
<212> PRT
<213> Homo sapiens

<400> 8488
Met Glu Ala Asp Ile Ile Thr Asn Leu Arg Cys Arg Leu Lys Glu Ala 
1               5                   10                  15      


Glu Glu Glu Arg Leu Lys Ala Ala Gln Tyr Gly Leu Gln Leu Val Glu 
            20                  25                  30          


Ser Gln Asn Glu Leu Gln Asn Gln Leu Asp Lys Cys Arg Asn Glu Met 
        35                  40                  45              


Met Thr Met Thr Glu Ser Tyr Glu Gln Glu Lys Tyr Thr Leu Gln Arg 
    50                  55                  60                  


Glu Val Glu Leu Lys Ser Arg Met Leu Glu Ser Leu Ser Cys Glu Cys 
65                  70                  75                  80  


Glu Ala Ile Lys Gln Gln Gln Lys 
                85              


<210> 8489
<211> 633
<212> PRT
<213> Homo sapiens

<400> 8489
Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr Cys Asp Cys Lys Ile Phe Lys Ile 
        35                  40                  45              


Cys Leu Val Val Thr Lys Glu Val Ser Arg Asp Ser Ser Leu Leu Arg 
    50                  55                  60                  


Asp Asp Leu Ile Gln Asp Val Glu Ile Gln Ile Ile Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Pro Pro Ile Val Gln Asn Cys Cys Leu Pro Ala Val Val Glu Arg 
                85                  90                  95      


Ser Asp Asn Phe Cys Arg Ala Gly Leu Ala Val Val Leu Arg His Ile 
            100                 105                 110         


Ile Gln Lys Ser Tyr Glu Ala Asp Pro Leu Lys Lys Glu Leu Leu Glu 
        115                 120                 125             


Leu Leu Gly Phe Lys Lys Thr Cys Leu Lys Ala Cys Ala Glu Val Ser 
    130                 135                 140                 


Gln Trp Thr Arg Leu Cys Glu Leu Thr Ile Pro Leu Ala Ile Glu Asn 
145                 150                 155                 160 


Phe Leu Arg Glu Ser Ser Asp Gln Pro Pro Thr Ile Pro Val Glu Ile 
                165                 170                 175     


Leu Gln Leu Glu Lys Lys Leu Ser Glu Pro Val Arg Val His Asn Asp 
            180                 185                 190         


Asp Lys Leu Arg Arg Gln Lys Leu Lys Gln Gln Lys Ala Asp Gly Val 
        195                 200                 205             


Gly Pro Pro Leu Thr Lys Gly Lys Ala Lys Ser Lys Val His Thr Gln 
    210                 215                 220                 


Glu Thr Ser Glu Gly Leu Asp Ser Ser Ser Lys Ser Leu Glu Leu Lys 
225                 230                 235                 240 


Val Ala Phe Ser Lys Leu Thr Val Gln Glu Glu Pro Ala Thr Thr Asn 
                245                 250                 255     


Arg Glu Pro Ser His Ile Arg Lys Ala Lys Ala Ser Asp Leu Pro Pro 
            260                 265                 270         


Leu Glu His Val Phe Ala Glu Gly Leu Tyr Phe Thr Leu Ala Asp Ile 
        275                 280                 285             


Val Leu Leu Pro Cys Ile His His Phe Leu Val Ile Ile Ser Arg Lys 
    290                 295                 300                 


Phe Ser Glu Lys Leu Val Glu Phe Pro Leu Leu Ala Ser Trp Tyr Gln 
305                 310                 315                 320 


Arg Ile Gln Glu Val Pro Gly Val Lys Thr Ala Ala Ser Lys Cys Gly 
                325                 330                 335     


Ile Gln Phe Leu His Leu Pro Lys Leu Leu Thr Thr Ser Thr Glu Gln 
            340                 345                 350         


His Pro Asn Leu Cys Glu Val Pro Gly Val Glu Glu Gln Ser Asp Pro 
        355                 360                 365             


Leu Phe Ile Gly Gly Pro Arg Pro Thr Met Ala Lys Leu Met Glu Lys 
    370                 375                 380                 


Gly Ile Glu Val Met Phe Ser Pro His Pro Cys Pro Thr Trp Thr Leu 
385                 390                 395                 400 


Asp Trp Asn Val Leu Pro Ala Ala Val Ser Pro Lys Glu Gly Lys Met 
                405                 410                 415     


Ser Ser Asp Arg Ala Leu Arg Lys Gln Gln Gln Leu Asn Asn Leu Val 
            420                 425                 430         


Tyr Val Val Thr Asn Gln Ala Lys Pro Gly Asp Arg Ile Val Asp Phe 
        435                 440                 445             


Cys Ser Gly Gly Gly His Val Gly Ile Val Leu Ala His Met Leu Pro 
    450                 455                 460                 


Ser Cys Gln Val Thr Leu Ile Glu Asn Lys Glu Leu Ser Leu Ile Arg 
465                 470                 475                 480 


Ala Lys Lys Arg Ser Asp Glu Leu Gly Leu Ser Asn Ile Trp Phe Ile 
                485                 490                 495     


Gln Ala Asn Met Glu Tyr Phe Thr Gly Met Phe Asn Ile Gly Val Ala 
            500                 505                 510         


Leu His Ala Cys Gly Val Ala Thr Asp Met Val Ile Glu His Cys Ile 
        515                 520                 525             


Lys Thr Arg Ala Ser Phe Val Thr Cys Pro Cys Cys Tyr Gly Phe Ile 
    530                 535                 540                 


Gln Asn Thr Ser Lys Phe Asn Phe Pro Lys Ser Glu Gln Phe Lys Lys 
545                 550                 555                 560 


Thr Leu Ser Tyr Lys Glu His Met Ile Leu Cys Arg Phe Ala Asp Gln 
                565                 570                 575     


Thr Ala Val Gln Leu Pro Pro Gln Arg Arg Leu Ile Gly Lys Gln Cys 
            580                 585                 590         


Met Cys Leu Val Asp Leu Asp Arg Ala Arg Ala Ala Glu Glu Cys Gly 
        595                 600                 605             


Tyr Ser Val Gln Val Ile Ser Met Glu Pro Glu Ser Cys Ser Pro Lys 
    610                 615                 620                 


Asn Asn Met Ile Val Gly Val Pro Ile 
625                 630             


<210> 8490
<211> 198
<212> PRT
<213> Homo sapiens

<400> 8490
Met Ala Thr Gly Asp Leu Lys Arg Ser Leu Arg Asn Leu Glu Gln Val 
1               5                   10                  15      


Leu Arg Leu Leu Asn Tyr Pro Glu Glu Val Asp Cys Val Gly Leu Ile 
            20                  25                  30          


Lys Gly Asp Pro Ala Ala Ser Leu Pro Ile Ile Ser Tyr Ser Phe Thr 
        35                  40                  45              


Ser Tyr Ser Pro Tyr Val Thr Glu Leu Ile Met Glu Ser Asn Val Glu 
    50                  55                  60                  


Leu Ile Ala Lys Asn Asp Leu Arg Phe Ile Asp Ala Val Tyr Lys Leu 
65                  70                  75                  80  


Leu Arg Asp Gln Phe Asn Tyr Lys Pro Ile Leu Thr Lys Lys Gln Phe 
                85                  90                  95      


Ile Gln Cys Gly Phe Ala Glu Trp Lys Ile Gln Ile Val Cys Asp Ile 
            100                 105                 110         


Leu Asn Cys Val Met Lys Lys His Lys Glu Leu Ser Ser Leu Gln Lys 
        115                 120                 125             


Ile Pro Ser Gln Gln Arg Lys Lys Ile Ser Ser Gly Lys Ser Glu Pro 
    130                 135                 140                 


Pro Leu Gly Asn Glu Lys Ile Ser Ala Glu Ala Val Gly Val Asp Ile 
145                 150                 155                 160 


Ser Gly Arg Phe Met Thr Ser Gly Lys Lys Lys Ala Val Val Ile Arg 
                165                 170                 175     


His Leu Tyr Asn Glu Asp Asn Val Asp Ile Ser Glu Asp Thr Leu Ser 
            180                 185                 190         


Pro Ile Thr Asp Val Asn 
        195             


<210> 8491
<211> 111
<212> PRT
<213> Homo sapiens

<400> 8491
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr 
            100                 105                 110     


<210> 8492
<211> 226
<212> PRT
<213> Homo sapiens

<400> 8492
Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175     


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190         


Leu Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr 
        195                 200                 205             


Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr 
    210                 215                 220                 


Cys Ala 
225     


<210> 8493
<211> 623
<212> PRT
<213> Homo sapiens

<400> 8493
Met Ser Asp Glu Val Phe Ser Thr Thr Leu Ala Tyr Thr Lys Ser Pro 
1               5                   10                  15      


Lys Val Thr Lys Arg Thr Thr Phe Gln Asp Glu Leu Ile Arg Ala Ile 
            20                  25                  30          


Thr Ala Arg Ser Ala Arg Gln Arg Ser Ser Glu Tyr Ser Asp Asp Phe 
        35                  40                  45              


Asp Ser Asp Glu Ile Val Ser Leu Gly Asp Phe Ser Asp Thr Ser Ala 
    50                  55                  60                  


Asp Glu Asn Ser Val Asn Lys Lys Met Asn Asp Phe His Ile Ser Asp 
65                  70                  75                  80  


Asp Glu Glu Lys Asn Pro Ser Lys Leu Leu Phe Leu Lys Thr Asn Lys 
                85                  90                  95      


Ser Asn Gly Asn Ile Thr Lys Asp Glu Pro Val Cys Ala Ile Lys Asn 
            100                 105                 110         


Glu Glu Glu Met Ala Pro Asp Gly Cys Glu Asp Ile Val Val Lys Ser 
        115                 120                 125             


Phe Ser Glu Ser Gln Asn Lys Asp Glu Glu Phe Glu Lys Asp Lys Ile 
    130                 135                 140                 


Lys Met Lys Pro Lys Pro Arg Ile Leu Ser Ile Lys Ser Thr Ser Ser 
145                 150                 155                 160 


Ala Glu Asn Asn Ser Leu Asp Thr Asp Asp His Phe Lys Pro Ser Pro 
                165                 170                 175     


Arg Pro Arg Ser Met Leu Lys Lys Lys Ser His Met Glu Glu Lys Asp 
            180                 185                 190         


Gly Leu Glu Asp Lys Glu Thr Ala Leu Ser Glu Glu Leu Glu Leu His 
        195                 200                 205             


Ser Ala Pro Ser Ser Leu Pro Thr Pro Asn Gly Ile Gln Leu Glu Ala 
    210                 215                 220                 


Glu Lys Lys Ala Phe Ser Glu Asn Leu Asp Pro Glu Asp Ser Cys Leu 
225                 230                 235                 240 


Thr Ser Leu Ala Ser Ser Ser Leu Lys Gln Ile Leu Gly Asp Ser Phe 
                245                 250                 255     


Ser Pro Gly Ser Glu Gly Asn Ala Ser Gly Lys Ala Asp His Val Thr 
            260                 265                 270         


Thr Ala Val Glu Lys Ser Lys Glu Ser Gln Val Thr Ala Asp Asp Leu 
        275                 280                 285             


Glu Glu Glu Lys Ala Lys Ala Glu Leu Ile Met Asp Asp Asp Arg Thr 
    290                 295                 300                 


Val Asp Pro Leu Leu Ser Lys Ser Gln Ser Ile Leu Ile Ser Thr Ser 
305                 310                 315                 320 


Ala Thr Ala Ser Ser Lys Lys Thr Ile Glu Asp Arg Asn Ile Lys Asn 
                325                 330                 335     


Lys Lys Ser Thr Asn Asn Arg Ala Ser Ser Ala Ser Ala Arg Leu Met 
            340                 345                 350         


Thr Ser Glu Phe Leu Lys Lys Ser Ser Ser Lys Arg Arg Thr Pro Ser 
        355                 360                 365             


Thr Thr Thr Ser Ser His Tyr Leu Gly Thr Leu Lys Val Leu Asp Gln 
    370                 375                 380                 


Lys Pro Ser Gln Lys Gln Ser Ile Glu Pro Asp Arg Ala Asp Asn Ile 
385                 390                 395                 400 


Arg Ala Ala Val Tyr Gln Glu Trp Leu Glu Lys Lys Asn Val Tyr Leu 
                405                 410                 415     


His Glu Met His Arg Ile Lys Arg Ile Glu Ser Glu Asn Leu Arg Ile 
            420                 425                 430         


Gln Asn Glu Gln Lys Lys Ala Ala Lys Arg Glu Glu Ala Leu Ala Ser 
        435                 440                 445             


Phe Glu Ala Trp Lys Ala Met Lys Glu Lys Glu Ala Lys Lys Ile Ala 
    450                 455                 460                 


Ala Lys Lys Arg Leu Glu Glu Lys Asn Lys Lys Lys Thr Glu Glu Glu 
465                 470                 475                 480 


Asn Ala Ala Arg Lys Gly Glu Ala Leu Gln Ala Phe Glu Lys Trp Lys 
                485                 490                 495     


Glu Lys Lys Met Glu Tyr Leu Lys Glu Lys Asn Arg Lys Glu Arg Glu 
            500                 505                 510         


Tyr Glu Arg Ala Lys Lys Gln Lys Glu Glu Glu Thr Val Ala Glu Lys 
        515                 520                 525             


Lys Lys Asp Asn Leu Thr Ala Val Glu Lys Trp Asn Glu Lys Lys Glu 
    530                 535                 540                 


Ala Phe Phe Lys Gln Lys Glu Lys Glu Lys Ile Asn Glu Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Leu Lys Arg Ala Glu Lys Lys Asp Lys Asp Lys Gln Ala Ile 
                565                 570                 575     


Asn Glu Tyr Glu Lys Trp Leu Glu Asn Lys Glu Lys Gln Glu Arg Ile 
            580                 585                 590         


Glu Arg Lys Gln Lys Lys Arg His Ser Phe Leu Glu Ser Glu Ala Leu 
        595                 600                 605             


Pro Pro Trp Ser Pro Pro Ser Arg Thr Val Phe Ala Lys Val Phe 
    610                 615                 620             


<210> 8494
<211> 84
<212> PRT
<213> Homo sapiens

<400> 8494
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu 
                


<210> 8495
<211> 330
<212> PRT
<213> Homo sapiens

<400> 8495
Met Asp Gln Gly Asp Thr Pro Thr Leu Glu Glu Asp Leu Lys Lys Leu 
1               5                   10                  15      


Gln Leu Ser Glu Phe Phe Asp Ile Phe Glu Lys Glu Lys Val Asp Lys 
            20                  25                  30          


Glu Ala Leu Ala Leu Cys Thr Asp Arg Asp Leu Gln Glu Ile Gly Ile 
        35                  40                  45              


Pro Leu Gly Pro Arg Lys Lys Ile Leu Asn Tyr Phe Ser Thr Arg Lys 
    50                  55                  60                  


Asn Ser Met Gly Ile Lys Arg Pro Ala Pro Gln Pro Ala Ser Gly Ala 
65                  70                  75                  80  


Asn Ile Pro Lys Glu Ser Glu Phe Cys Ser Ser Ser Asn Thr Arg Asn 
                85                  90                  95      


Gly Asp Tyr Leu Asp Val Gly Ile Gly Gln Val Ser Val Lys Tyr Pro 
            100                 105                 110         


Arg Leu Ile Tyr Lys Pro Glu Ile Phe Phe Ala Phe Gly Ser Pro Ile 
        115                 120                 125             


Gly Met Phe Leu Thr Val Arg Gly Leu Lys Arg Ile Asp Pro Asn Tyr 
    130                 135                 140                 


Arg Phe Pro Thr Cys Lys Gly Phe Phe Asn Ile Tyr His Pro Phe Asp 
145                 150                 155                 160 


Pro Val Ala Tyr Arg Ile Glu Pro Met Val Val Pro Gly Val Glu Phe 
                165                 170                 175     


Glu Pro Met Leu Ile Pro His His Lys Gly Arg Lys Arg Met His Leu 
            180                 185                 190         


Glu Leu Arg Glu Gly Leu Thr Arg Met Ser Met Asp Leu Lys Asn Asn 
        195                 200                 205             


Leu Leu Gly Ser Leu Arg Met Ala Trp Lys Ser Phe Thr Arg Ala Pro 
    210                 215                 220                 


Tyr Pro Ala Leu Gln Ala Ser Glu Thr Pro Glu Glu Thr Glu Ala Glu 
225                 230                 235                 240 


Pro Glu Ser Thr Ser Glu Lys Pro Ser Asp Val Asn Thr Glu Glu Thr 
                245                 250                 255     


Ser Val Ala Val Lys Glu Glu Val Leu Pro Ile Asn Val Gly Met Leu 
            260                 265                 270         


Asn Gly Gly Gln Arg Ile Asp Tyr Val Leu Gln Glu Lys Pro Ile Glu 
        275                 280                 285             


Ser Phe Asn Glu Tyr Leu Phe Ala Leu Gln Ser His Leu Cys Tyr Trp 
    290                 295                 300                 


Glu Ser Glu Asp Thr Val Leu Leu Val Leu Lys Glu Ile Tyr Gln Thr 
305                 310                 315                 320 


Gln Gly Ile Phe Leu Asp Gln Pro Leu Gln 
                325                 330 


<210> 8496
<211> 460
<212> PRT
<213> Homo sapiens

<400> 8496
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg Cys Thr Leu 
        115                 120                 125             


Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu Asn Val Glu 
    130                 135                 140                 


Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu Gln Arg Glu 
145                 150                 155                 160 


Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu Lys Leu Asp 
                165                 170                 175     


Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln Lys Thr Ala 
            180                 185                 190         


Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu Glu Glu His 
        195                 200                 205             


Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Leu Gln Thr Gly Leu 
    210                 215                 220                 


Glu Ile Ser Lys Ile Ile Met Ser Ser Val Ser Asn Leu Lys His Ser 
225                 230                 235                 240 


Lys Glu Lys Lys Lys Ser Ser Lys Lys Thr Lys Cys Ile Lys Arg Arg 
                245                 250                 255     


Pro Pro Trp Gln Ile Cys Ser Lys Phe Gly Ala Leu Pro Phe Val Ala 
            260                 265                 270         


Glu Lys Met Arg Gln His Arg Asp Pro His Ile Leu Gln Lys Pro Phe 
        275                 280                 285             


Asn Val Thr Glu Thr Arg Cys Leu Pro Lys Pro Ser Arg Thr Thr Ser 
    290                 295                 300                 


Trp Cys Lys Ala Ile Pro Pro Asp Ser Glu Lys Ser Ile Ser Ile Cys 
305                 310                 315                 320 


Asp Asn Leu Ser Glu Leu Leu Met Ala Met Gln Asp Glu Leu Asp Gln 
                325                 330                 335     


Met Ser Met Glu His Gln Glu Leu Leu Lys Gln Met Lys Glu Thr Glu 
            340                 345                 350         


Ser His Ser Val Cys Asp Asp Ile Glu Cys Glu Leu Glu Cys Leu Leu 
        355                 360                 365             


Lys Lys Met Glu Ile Lys Gly Glu Gln Ile Ser Lys Leu Lys Lys His 
    370                 375                 380                 


Gln Asp Ser Val Cys Lys Leu Gln Gln Lys Val Gln Asn Ser Lys Met 
385                 390                 395                 400 


Ser Glu Ala Ser Gly Ile Gln Gln Glu Asp Ser Tyr Pro Lys Gly Ser 
                405                 410                 415     


Lys Asn Ile Lys Asn Ser Pro Arg Lys Cys Leu Thr Asp Thr Asn Leu 
            420                 425                 430         


Phe Gln Lys Asn Ser Ser Phe His Pro Ile Arg Val His Asn Leu Gln 
        435                 440                 445             


Met Lys Leu Arg Arg Asp Asp Ile Met Trp Glu Gln 
    450                 455                 460 


<210> 8497
<211> 355
<212> PRT
<213> Homo sapiens

<400> 8497
Met Thr Gly Ser Ala Ala Asp Thr His Arg Cys Pro His Pro Lys Gly 
1               5                   10                  15      


Ala Lys Gly Thr Arg Ser Arg Ser Ser His Ala Arg Pro Val Ser Leu 
            20                  25                  30          


Ala Thr Ser Gly Gly Ser Glu Glu Glu Asp Lys Asp Gly Gly Val Leu 
        35                  40                  45              


Phe His Val Asn Lys Ser Gly Phe Pro Ile Asp Ser His Thr Trp Glu 
    50                  55                  60                  


Arg Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met 
65                  70                  75                  80  


Val Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro 
                85                  90                  95      


Gln Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln 
            100                 105                 110         


Ala Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr 
        115                 120                 125             


Gln Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu 
    130                 135                 140                 


Thr Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu 
145                 150                 155                 160 


Ala Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser Ile Glu 
                165                 170                 175     


Arg Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe His 
            180                 185                 190         


His Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser Leu Gly 
        195                 200                 205             


Met Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe Arg Thr 
    210                 215                 220                 


Leu Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys Tyr Leu 
225                 230                 235                 240 


His Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His Glu Pro 
                245                 250                 255     


His Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn Val Ser 
            260                 265                 270         


Lys Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr Ala Arg 
        275                 280                 285             


Asp Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala His Ser Pro Thr 
    290                 295                 300                 


Gln Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg Arg Arg Gln Ala 
305                 310                 315                 320 


Ser Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser Pro Ala Leu Pro 
                325                 330                 335     


Glu Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu Val Gly Tyr Gln 
            340                 345                 350         


Ile Arg Ile 
        355 


<210> 8498
<211> 127
<212> PRT
<213> Homo sapiens

<400> 8498
Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser 
        115                 120                 125         


<210> 8499
<211> 169
<212> PRT
<213> Homo sapiens

<400> 8499
Met His Lys Leu Gln Ser Gly Ile Gly Arg Leu Ile Leu Lys Glu Glu 
1               5                   10                  15      


Met Lys Ala Arg Ser Ser Ser Tyr Ala Asp Pro Trp Thr Pro Pro Arg 
            20                  25                  30          


Ser Ser Thr Ser Ser Arg Glu Ala Leu His Thr Ala Gly Tyr Glu Met 
        35                  40                  45              


Ser Leu Asn Gly Ser Pro Arg Ser His Tyr Leu Ala Asp Ser Asp Pro 
    50                  55                  60                  


Leu Ile Ser Lys Ser Ala Ser Leu Pro Ala Tyr Arg Arg Asn Gly Leu 
65                  70                  75                  80  


His Arg Thr Pro Ser Ala Asp Leu Phe His Tyr Asp Ser Met Asn Ala 
                85                  90                  95      


Val Asn Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr Glu Leu Leu 
            100                 105                 110         


Leu Val Thr Thr Arg Gly Arg Asn Arg Leu Pro Lys Asp Val Asp Arg 
        115                 120                 125             


Thr Arg Leu Glu Arg His Leu Ser Gln Glu Glu Phe Tyr Gln Val Phe 
    130                 135                 140                 


Gly Met Thr Ile Ser Glu Phe Asp Arg Leu Ala Leu Trp Lys Arg Asn 
145                 150                 155                 160 


Glu Leu Lys Lys Gln Ala Arg Leu Phe 
                165                 


<210> 8500
<211> 47
<212> PRT
<213> Homo sapiens

<400> 8500
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr 
        35                  40                  45          


<210> 8501
<211> 185
<212> PRT
<213> Homo sapiens

<400> 8501
Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu Asp 
1               5                   10                  15      


Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala Pro 
            20                  25                  30          


Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn Gly 
        35                  40                  45              


Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile His 
    50                  55                  60                  


Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val Phe 
65                  70                  75                  80  


Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser Leu 
                85                  90                  95      


Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu Pro 
            100                 105                 110         


Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser Ala 
        115                 120                 125             


Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu 
    130                 135                 140                 


Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro 
145                 150                 155                 160 


Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp 
                165                 170                 175     


Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            180                 185 


<210> 8502
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8502
Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30          


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45              


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60                  


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80  


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95      


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110         


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125             


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140                 


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160 


Glu Glu Lys 
            


<210> 8503
<211> 304
<212> PRT
<213> Homo sapiens

<400> 8503
Met Ser Lys Arg Arg Arg Leu Lys Gln Gly Glu Pro Ile Met Thr Gly 
1               5                   10                  15      


Lys Thr Gln Thr Ser Asn Val Thr Asn Lys Asn Asp Pro Lys Ser Ile 
            20                  25                  30          


Asn Ser Arg Val Phe Ile Gly Asn Leu Asn Thr Ala Ile Val Lys Lys 
        35                  40                  45              


Val Asp Ile Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Val Gly Cys 
    50                  55                  60                  


Ser Val His Lys Gly Tyr Ala Phe Val Gln Tyr Met Ser Glu Arg His 
65                  70                  75                  80  


Ala Arg Ala Ala Val Ala Gly Glu Asn Ala Arg Val Ile Ala Gly Gln 
                85                  90                  95      


Pro Leu Asp Ile Asn Met Ala Gly Glu Pro Lys Pro Tyr Arg Pro Lys 
            100                 105                 110         


Pro Gly Asn Lys Arg Pro Leu Ser Ala Leu Tyr Arg Leu Glu Ser Lys 
        115                 120                 125             


Glu Pro Phe Leu Ser Val Gly Gly Tyr Val Phe Asp Tyr Asp Tyr Tyr 
    130                 135                 140                 


Arg Asp Asp Phe Tyr Asn Arg Leu Phe Asp Tyr His Gly Arg Val Pro 
145                 150                 155                 160 


Pro Pro Pro Arg Ala Val Ile Pro Leu Lys Arg Pro Arg Val Ala Val 
                165                 170                 175     


Thr Thr Thr Arg Arg Gly Lys Gly Val Phe Ser Met Lys Gly Gly Ser 
            180                 185                 190         


Arg Ser Thr Ala Ser Gly Ser Thr Gly Ser Lys Leu Lys Ser Asp Glu 
        195                 200                 205             


Leu Gln Thr Ile Lys Lys Glu Leu Thr Gln Ile Lys Thr Lys Ile Asp 
    210                 215                 220                 


Ser Leu Leu Gly Arg Leu Glu Lys Ile Glu Lys Gln Gln Lys Ala Glu 
225                 230                 235                 240 


Ala Glu Ala Gln Lys Lys Gln Leu Glu Glu Ser Leu Val Leu Ile Gln 
                245                 250                 255     


Glu Glu Cys Val Ser Glu Ile Ala Asp His Ser Thr Glu Glu Pro Ala 
            260                 265                 270         


Glu Gly Gly Pro Asp Ala Asp Gly Glu Glu Met Thr Asp Gly Ile Glu 
        275                 280                 285             


Glu Asp Phe Asp Glu Asp Gly Gly His Glu Leu Phe Leu Gln Ile Lys 
    290                 295                 300                 


<210> 8504
<211> 134
<212> PRT
<213> Homo sapiens

<400> 8504
Met Pro Ser Ala Glu Ala Lys Leu Lys Lys Asn Arg Cys Ala Asn Cys 
1               5                   10                  15      


Phe Asp Cys Pro Gly Cys Met His Thr Leu Ser Thr Arg Ala Thr Ser 
            20                  25                  30          


Ile Ser Thr Gln Leu Pro Asp Asp Pro Ala Lys Thr Thr Met Lys Lys 
        35                  40                  45              


Ala Tyr Tyr Leu Ala Cys Gly Phe Cys Arg Trp Thr Ser Arg Asp Val 
    50                  55                  60                  


Gly Met Ala Asp Lys Ser Val Ala Ser Gly Gly Trp Gln Glu Pro Glu 
65                  70                  75                  80  


Asn Pro His Thr Gln Arg Met Asn Lys Leu Ile Glu Tyr Tyr Gln Gln 
                85                  90                  95      


Leu Ala Gln Lys Glu Lys Val Glu Arg Asp Arg Lys Lys Leu Ala Arg 
            100                 105                 110         


Arg Arg Asn Tyr Met Pro Leu Ala Phe Ser Asp Lys Tyr Gly Leu Gly 
        115                 120                 125             


Thr Arg Leu Gln Arg Pro 
    130                 


<210> 8505
<211> 409
<212> PRT
<213> Homo sapiens

<400> 8505
Met Trp Arg Val Ile Glu Pro Pro Cys Pro Gly Ala Pro Ser Thr Glu 
1               5                   10                  15      


Asn Gly Lys Ser Val His Trp Lys Leu Gly Ala Asp Lys Glu Val Trp 
            20                  25                  30          


Val Trp Val Met Gly Glu His His Leu Asp Lys Pro Tyr Asp Val Leu 
        35                  40                  45              


Cys Asn Glu Ile Ile Ala Glu Arg Ala Arg Leu Lys Ala Glu Gln Glu 
    50                  55                  60                  


Ala Glu Glu Pro Arg Lys Thr His Ser Glu Glu Phe Thr Asn Ser Leu 
65                  70                  75                  80  


Lys Thr Lys Ser Gln Tyr His Asp Leu Gln Ala Pro Asp Asn Gln Gln 
                85                  90                  95      


Thr Lys Asp Ile Trp Lys Lys Val Ala Glu Lys Glu Glu Leu Glu Gln 
            100                 105                 110         


Gly Ser Arg Pro Ala Pro Thr Leu Glu Glu Glu Lys Ile Arg Ser Leu 
        115                 120                 125             


Ser Ser Ser Ser Arg Asn Ile Gln Gln Met Leu Ala Asp Ser Ile Asn 
    130                 135                 140                 


Arg Met Lys Ala Tyr Ala Phe His Gln Lys Lys Glu Ser Met Lys Lys 
145                 150                 155                 160 


Lys Gln Asp Glu Glu Ile Asn Gln Ile Glu Glu Glu Arg Thr Lys Gln 
                165                 170                 175     


Ile Cys Lys Ser Trp Lys Glu Asp Ser Glu Trp Gln Ala Ser Leu Arg 
            180                 185                 190         


Lys Ser Lys Ala Ala Asp Glu Lys Arg Arg Ser Leu Ala Lys Gln Ala 
        195                 200                 205             


Arg Glu Asp Tyr Lys Arg Leu Ser Leu Gly Ala Gln Lys Gly Arg Gly 
    210                 215                 220                 


Gly Glu Arg Leu Gln Ser Pro Leu Arg Val Pro Gln Lys Pro Glu Arg 
225                 230                 235                 240 


Pro Pro Leu Pro Pro Lys Pro Gln Phe Leu Asn Ser Gly Ala Tyr Pro 
                245                 250                 255     


Gln Lys Pro Leu Arg Asn Gln Gly Val Val Arg Thr Leu Ser Ser Ser 
            260                 265                 270         


Ala Gln Glu Asp Ile Ile Arg Trp Phe Lys Glu Glu Gln Leu Pro Leu 
        275                 280                 285             


Arg Ala Gly Tyr Gln Lys Thr Ser Asp Thr Ile Ala Pro Trp Phe His 
    290                 295                 300                 


Gly Ile Leu Thr Leu Lys Lys Ala Asn Glu Leu Leu Leu Ser Thr Gly 
305                 310                 315                 320 


Met Pro Gly Ser Phe Leu Ile Arg Val Ser Glu Arg Ile Lys Gly Tyr 
                325                 330                 335     


Ala Leu Ser Tyr Leu Ser Glu Asp Gly Cys Lys His Phe Leu Ile Asp 
            340                 345                 350         


Ala Ser Ala Asp Ala Tyr Ser Phe Leu Gly Val Asp Gln Leu Gln His 
        355                 360                 365             


Ala Thr Leu Ala Asp Leu Val Glu Tyr His Lys Glu Glu Pro Ile Thr 
    370                 375                 380                 


Ser Leu Gly Lys Glu Leu Leu Leu Tyr Pro Cys Gly Gln Gln Asp Gln 
385                 390                 395                 400 


Leu Pro Asp Tyr Leu Glu Leu Phe Glu 
                405                 


<210> 8506
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8506
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr Asp 
            100                 105                 110         


Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Tyr Met Ser 
        115                 120                 125             


Ala 
    


<210> 8507
<211> 259
<212> PRT
<213> Homo sapiens

<400> 8507
Met Val Gly Arg Glu Lys Glu Leu Ser Ile His Phe Val Pro Gly Ser 
1               5                   10                  15      


Cys Arg Leu Val Glu Glu Glu Val Asn Ile Pro Asn Arg Arg Val Leu 
            20                  25                  30          


Val Thr Gly Ala Thr Gly Leu Leu Gly Arg Ala Val His Lys Glu Phe 
        35                  40                  45              


Gln Gln Asn Asn Trp His Ala Val Gly Cys Gly Phe Arg Arg Ala Arg 
    50                  55                  60                  


Pro Lys Phe Glu Gln Val Asn Leu Leu Asp Ser Asn Ala Val His His 
65                  70                  75                  80  


Ile Ile His Asp Phe Gln Pro His Val Ile Val His Cys Ala Ala Glu 
                85                  90                  95      


Arg Arg Pro Asp Val Val Glu Asn Gln Pro Asp Ala Ala Ser Gln Leu 
            100                 105                 110         


Asn Val Asp Ala Ser Gly Asn Leu Ala Lys Glu Ala Ala Ala Val Gly 
        115                 120                 125             


Ala Phe Leu Ile Tyr Ile Ser Ser Asp Tyr Val Phe Asp Gly Thr Asn 
    130                 135                 140                 


Pro Pro Tyr Arg Glu Glu Asp Ile Pro Ala Pro Leu Asn Leu Tyr Gly 
145                 150                 155                 160 


Lys Thr Lys Leu Asp Gly Glu Lys Ala Val Leu Glu Asn Asn Leu Gly 
                165                 170                 175     


Ala Ala Val Leu Arg Ile Pro Ile Leu Tyr Gly Glu Val Glu Lys Leu 
            180                 185                 190         


Glu Glu Ser Ala Val Thr Val Met Phe Asp Lys Val Gln Phe Ser Asn 
        195                 200                 205             


Lys Ser Ala Asn Met Asp His Trp Gln Gln Arg Phe Pro Thr His Val 
    210                 215                 220                 


Lys Asp Val Ala Thr Val Cys Arg Gln Leu Ala Glu Lys Arg Met Leu 
225                 230                 235                 240 


Val Arg Arg Ile Pro Glu Ser Cys Leu Ser Glu Gly Pro Leu Cys Leu 
                245                 250                 255     


Phe His Ala 
            


<210> 8508
<211> 182
<212> PRT
<213> Homo sapiens

<400> 8508
Ser Tyr Asp Ser Thr Phe Ser Tyr Val Thr His Glu Asp Ile Cys Asn 
1               5                   10                  15      


Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala Pro Ser Gly Thr 
            20                  25                  30          


Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn Gly Gln Lys Lys 
        35                  40                  45              


Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile His Val Leu Leu 
    50                  55                  60                  


Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val Phe Pro Val Pro 
65                  70                  75                  80  


Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser Leu Thr Pro Val 
                85                  90                  95      


Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu Pro Glu Gln His 
            100                 105                 110         


Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser Ala Thr Asp Ile 
        115                 120                 125             


Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu Leu Met Ser 
    130                 135                 140                 


Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro Ala Asp Asp 
145                 150                 155                 160 


Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp Leu Phe Asp 
                165                 170                 175     


Val Gln Ile Leu Asn Tyr 
            180         


<210> 8509
<211> 53
<212> PRT
<213> Homo sapiens

<400> 8509
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln 
    50              


<210> 8510
<211> 1005
<212> PRT
<213> Homo sapiens

<400> 8510
Met Ala Gly Ala Leu Arg Arg Gly Arg Ala Leu Gly Ser Arg Pro Ser 
1               5                   10                  15      


Gly Pro Thr Val Ser Ser Arg Arg Ser Pro Gln Cys Pro Val Ala Gln 
            20                  25                  30          


Glu Gly Leu Gly Ala Arg Ser Arg Pro Arg Val Ala Pro Arg Ser Leu 
        35                  40                  45              


Ala Arg Cys Gly Pro Ser Ser Arg Leu Met Gly Trp Lys Pro Ser Glu 
    50                  55                  60                  


Ala Arg Gly Gln Ser Gln Ser Phe Gln Ala Ser Gly Leu Gln Pro Arg 
65                  70                  75                  80  


Ser Leu Lys Ala Ala Arg Arg Ala Thr Gly Arg Pro Asp Arg Ser Arg 
                85                  90                  95      


Ala Ala Arg Pro Thr Met Asp Pro Ser Ala His Arg Ser Arg Ala Ala 
            100                 105                 110         


Pro Pro Asn Met Asp Pro Asp Pro Gln Ala Gly Val Gln Val Gly Met 
        115                 120                 125             


Arg Val Val Arg Gly Val Asp Trp Lys Trp Gly Gln Gln Asp Gly Gly 
    130                 135                 140                 


Glu Gly Gly Val Gly Thr Val Val Glu Leu Gly Arg His Gly Ser Pro 
145                 150                 155                 160 


Ser Thr Pro Asp Arg Thr Val Val Val Gln Trp Asp Gln Gly Thr Arg 
                165                 170                 175     


Thr Asn Tyr Arg Ala Gly Tyr Gln Gly Ala His Asp Leu Leu Leu Tyr 
            180                 185                 190         


Asp Asn Ala Gln Ile Gly Val Arg His Pro Asn Ile Ile Cys Asp Cys 
        195                 200                 205             


Cys Lys Lys His Gly Leu Arg Gly Met Arg Trp Lys Cys Arg Val Cys 
    210                 215                 220                 


Leu Asp Tyr Asp Leu Cys Thr Gln Cys Tyr Met His Asn Lys His Glu 
225                 230                 235                 240 


Leu Ala His Ala Phe Asp Arg Tyr Glu Thr Ala His Ser Arg Pro Val 
                245                 250                 255     


Thr Leu Ser Pro Arg Gln Gly Leu Pro Arg Ile Pro Leu Arg Gly Ile 
            260                 265                 270         


Phe Gln Gly Ala Lys Val Val Arg Gly Pro Asp Trp Glu Trp Gly Ser 
        275                 280                 285             


Gln Asp Gly Lys Pro Ala Glu Leu Gln Arg Arg Val Ser Ala Asp Ser 
    290                 295                 300                 


Gln Pro Phe Gln His Gly Asp Lys Val Lys Cys Leu Leu Asp Thr Asp 
305                 310                 315                 320 


Val Leu Arg Glu Met Gln Glu Gly His Gly Gly Trp Asn Pro Arg Met 
                325                 330                 335     


Ala Glu Phe Ile Gly Gln Thr Gly Thr Val His Arg Ile Thr Asp Arg 
            340                 345                 350         


Gly Asp Val Arg Val Gln Phe Asn His Glu Thr Arg Trp Thr Phe His 
        355                 360                 365             


Pro Gly Ala Leu Thr Lys His His Ser Phe Trp Val Gly Asp Val Val 
    370                 375                 380                 


Arg Val Ile Gly Asp Leu Asp Thr Val Lys Arg Leu Gln Ala Gly His 
385                 390                 395                 400 


Gly Glu Trp Thr Asp Asp Met Ala Pro Ala Leu Gly Arg Val Gly Lys 
                405                 410                 415     


Val Val Lys Val Phe Gly Asp Gly Asn Leu Arg Val Ala Val Ala Gly 
            420                 425                 430         


Gln Arg Trp Thr Phe Ser Pro Ser Cys Leu Val Ala Tyr Arg Pro Glu 
        435                 440                 445             


Glu Asp Ala Asn Leu Asp Val Ala Glu Arg Ala Arg Glu Asn Lys Ser 
    450                 455                 460                 


Ser Leu Ser Val Ala Leu Asp Lys Leu Arg Ala Gln Lys Ser Asp Pro 
465                 470                 475                 480 


Glu His Pro Gly Arg Leu Val Val Glu Val Ala Leu Gly Asn Ala Ala 
                485                 490                 495     


Arg Ala Leu Asp Leu Leu Arg Arg Arg Pro Glu Gln Val Asp Thr Lys 
            500                 505                 510         


Asn Gln Gly Arg Thr Ala Leu Gln Val Ala Ala Tyr Leu Gly Gln Val 
        515                 520                 525             


Glu Leu Ile Arg Leu Leu Leu Gln Ala Arg Ala Gly Val Asp Leu Pro 
    530                 535                 540                 


Asp Asp Glu Gly Asn Thr Ala Leu His Tyr Ala Ala Leu Gly Asn Gln 
545                 550                 555                 560 


Pro Glu Ala Thr Arg Val Leu Leu Ser Ala Gly Cys Arg Ala Asp Ala 
                565                 570                 575     


Ile Asn Ser Thr Gln Ser Thr Ala Leu His Val Ala Val Gln Arg Gly 
            580                 585                 590         


Phe Leu Glu Val Val Arg Ala Leu Cys Glu Arg Gly Cys Asp Val Asn 
        595                 600                 605             


Leu Pro Asp Ala His Ser Asp Thr Pro Leu His Ser Ala Ile Ser Ala 
    610                 615                 620                 


Gly Thr Gly Ala Ser Gly Ile Val Glu Val Leu Thr Glu Val Pro Asn 
625                 630                 635                 640 


Ile Asp Val Thr Ala Thr Asn Ser Gln Gly Phe Thr Leu Leu His His 
                645                 650                 655     


Ala Ser Leu Lys Gly His Ala Leu Ala Val Arg Lys Ile Leu Ala Arg 
            660                 665                 670         


Ala Arg Gln Leu Val Asp Ala Lys Lys Glu Asp Gly Phe Thr Ala Leu 
        675                 680                 685             


His Leu Ala Ala Leu Asn Asn His Arg Glu Val Ala Gln Ile Leu Ile 
    690                 695                 700                 


Arg Glu Gly Arg Cys Asp Val Asn Val Arg Asn Arg Lys Leu Gln Ser 
705                 710                 715                 720 


Pro Leu His Leu Ala Val Gln Gln Ala His Val Gly Leu Val Pro Leu 
                725                 730                 735     


Leu Val Asp Ala Gly Cys Ser Val Asn Ala Glu Asp Glu Glu Gly Asp 
            740                 745                 750         


Thr Ala Leu His Val Ala Leu Gln Arg His Gln Leu Leu Pro Leu Val 
        755                 760                 765             


Ala Asp Gly Ala Gly Gly Asp Pro Gly Pro Leu Gln Leu Leu Ser Arg 
    770                 775                 780                 


Leu Gln Ala Ser Gly Leu Pro Gly Ser Ala Glu Leu Thr Val Gly Ala 
785                 790                 795                 800 


Ala Val Ala Cys Phe Leu Ala Leu Glu Gly Ala Asp Val Ser Tyr Thr 
                805                 810                 815     


Asn His Arg Gly Arg Ser Pro Leu Asp Leu Ala Ala Glu Gly Arg Val 
            820                 825                 830         


Leu Lys Ala Leu Gln Gly Cys Ala Gln Arg Phe Arg Glu Arg Gln Ala 
        835                 840                 845             


Gly Gly Gly Ala Ala Pro Gly Pro Arg Gln Thr Leu Gly Thr Pro Asn 
    850                 855                 860                 


Thr Val Thr Asn Leu His Val Gly Ala Ala Pro Gly Pro Glu Ala Ala 
865                 870                 875                 880 


Glu Cys Leu Val Cys Ser Glu Leu Ala Leu Leu Val Leu Phe Ser Pro 
                885                 890                 895     


Cys Gln His Arg Thr Val Cys Glu Glu Cys Ala Arg Arg Met Lys Lys 
            900                 905                 910         


Cys Ile Arg Cys Gln Val Val Val Ser Lys Lys Leu Arg Pro Asp Gly 
        915                 920                 925             


Ser Glu Val Ala Ser Ala Ala Pro Ala Pro Gly Pro Pro Arg Gln Leu 
    930                 935                 940                 


Val Glu Glu Leu Gln Ser Arg Tyr Arg Gln Met Glu Glu Arg Ile Thr 
945                 950                 955                 960 


Cys Pro Ile Cys Ile Asp Ser His Ile Arg Leu Val Phe Gln Cys Gly 
                965                 970                 975     


His Gly Ala Cys Ala Pro Cys Gly Ser Ala Leu Ser Ala Cys Pro Ile 
            980                 985                 990         


Cys Arg Gln Pro Ile Arg Asp Arg  Ile Gln Ile Phe Val  
        995                 1000                 1005 


<210> 8511
<211> 97
<212> PRT
<213> Homo sapiens

<400> 8511
Met Ala Ser Ser Ala Glu Leu Asp Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Ser Leu Ile Arg Thr 
            20                  25                  30          


Ile Ser Leu Gly Lys Glu Leu Gln Thr Val Pro Gln Thr Glu Val Asp 
        35                  40                  45              


Lys Ala Asn Gly Lys Gln Leu Val Glu Ile Phe Thr Ser His Ser Cys 
    50                  55                  60                  


Ser Tyr Trp Ala Gly Met Ala Ala Ile Gln Val Phe Glu Lys Met Asn 
65                  70                  75                  80  


Gln Thr His Leu Ser Gly Arg Ala Asp Glu His Cys Val Met Pro Pro 
                85                  90                  95      


Pro 
    


<210> 8512
<211> 230
<212> PRT
<213> Homo sapiens

<400> 8512
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg Cys Thr Leu 
        115                 120                 125             


Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu Asn Val Glu 
    130                 135                 140                 


Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu Gln Arg Glu 
145                 150                 155                 160 


Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu Lys Leu Asp 
                165                 170                 175     


Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln Lys Thr Ala 
            180                 185                 190         


Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu Glu Glu His 
        195                 200                 205             


Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Leu Gln Thr Gly Leu 
    210                 215                 220                 


Glu Ile Ser Lys Ile Ile 
225                 230 


<210> 8513
<211> 207
<212> PRT
<213> Homo sapiens

<400> 8513
Met Asp Arg Gly Glu Gln Gly Leu Leu Arg Thr Asp Pro Val Pro Glu 
1               5                   10                  15      


Glu Gly Glu Asp Val Ala Ala Thr Ile Ser Ala Thr Glu Thr Leu Ser 
            20                  25                  30          


Glu Glu Glu Gln Glu Glu Leu Arg Arg Glu Leu Ala Lys Val Glu Glu 
        35                  40                  45              


Glu Ile Gln Thr Leu Ser Gln Val Leu Ala Ala Lys Glu Lys His Leu 
    50                  55                  60                  


Ala Glu Ile Lys Arg Lys Leu Gly Ile Asn Ser Leu Gln Glu Leu Lys 
65                  70                  75                  80  


Gln Asn Ile Ala Lys Gly Trp Gln Asp Val Thr Ala Thr Ser Ala Tyr 
                85                  90                  95      


Lys Lys Thr Ser Glu Thr Leu Ser Gln Ala Gly Gln Lys Ala Ser Ala 
            100                 105                 110         


Ala Phe Ser Ser Val Gly Ser Val Ile Thr Lys Lys Leu Glu Asp Val 
        115                 120                 125             


Lys Leu Gln Ala Phe Ser His Ser Phe Ser Ile Arg Ser Ile Gln His 
    130                 135                 140                 


Ser Ile Ser Met Pro Ala Met Arg Asn Ser Pro Thr Phe Lys Ser Phe 
145                 150                 155                 160 


Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys Pro 
                165                 170                 175     


Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala Ser 
            180                 185                 190         


Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu 
        195                 200                 205         


<210> 8514
<211> 128
<212> PRT
<213> Homo sapiens

<400> 8514
Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
1               5                   10                  15      


Arg His Phe Asn Ala Pro Ser His Val Arg Arg Lys Ile Met Ser Ser 
            20                  25                  30          


Pro Leu Ser Lys Glu Leu Arg Gln Lys Tyr Asn Val Arg Ser Met Pro 
        35                  40                  45              


Ile Arg Lys Asp Asp Glu Val Gln Val Val Arg Gly His Tyr Lys Gly 
    50                  55                  60                  


Gln Gln Ile Gly Lys Val Val Gln Val Tyr Arg Lys Lys Tyr Val Ile 
65                  70                  75                  80  


Tyr Ile Glu Arg Val Gln Arg Glu Lys Ala Asn Gly Thr Thr Val His 
                85                  90                  95      


Val Gly Ile His Pro Ser Lys Val Val Ile Thr Arg Leu Lys Leu Asp 
            100                 105                 110         


Lys Asp Arg Lys Lys Ile Leu Glu Arg Lys Ala Lys Ser Arg Gln Val 
        115                 120                 125             


<210> 8515
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 8515
Gly Leu Thr Lys Gln Leu Leu Asp Asp Thr Ile Gly Ile His Pro Thr 
1               5                   10                  15      


Cys Gly Glu Val Phe Thr Thr Leu Glu Ile Thr Lys Ser Ser Gly Leu 
            20                  25                  30          


Asp Ile Thr Gln Lys Gly Cys Cys Gly 
        35                  40      


<210> 8516
<211> 454
<212> PRT
<213> Homo sapiens

<400> 8516
Met Leu Lys Gln Ile Leu Ser Glu Met Tyr Ile Asp Pro Asp Leu Leu 
1               5                   10                  15      


Ala Glu Leu Ser Glu Glu Gln Lys Gln Ile Leu Phe Phe Lys Met Arg 
            20                  25                  30          


Glu Glu Gln Ile Arg Arg Trp Lys Glu Arg Glu Ala Ala Met Glu Arg 
        35                  40                  45              


Lys Glu Ser Leu Pro Val Lys Pro Arg Pro Lys Lys Glu Asn Gly Lys 
    50                  55                  60                  


Ser Val His Trp Lys Leu Gly Ala Asp Lys Glu Val Trp Val Trp Val 
65                  70                  75                  80  


Met Gly Glu His His Leu Asp Lys Pro Tyr Asp Val Leu Cys Asn Glu 
                85                  90                  95      


Ile Ile Ala Glu Arg Ala Arg Leu Lys Ala Glu Gln Glu Ala Glu Glu 
            100                 105                 110         


Pro Arg Lys Thr His Ser Glu Glu Phe Thr Asn Ser Leu Lys Thr Lys 
        115                 120                 125             


Ser Gln Tyr His Asp Leu Gln Ala Pro Asp Asn Gln Gln Thr Lys Asp 
    130                 135                 140                 


Ile Trp Lys Lys Val Ala Glu Lys Glu Glu Leu Glu Gln Gly Ser Arg 
145                 150                 155                 160 


Pro Ala Pro Thr Leu Glu Glu Glu Lys Ile Arg Ser Leu Ser Ser Ser 
                165                 170                 175     


Ser Arg Asn Ile Gln Gln Met Leu Ala Asp Ser Ile Asn Arg Met Lys 
            180                 185                 190         


Ala Tyr Ala Phe His Gln Lys Lys Glu Ser Met Lys Lys Lys Gln Asp 
        195                 200                 205             


Glu Glu Ile Asn Gln Ile Glu Glu Glu Arg Thr Lys Gln Ile Cys Lys 
    210                 215                 220                 


Ser Trp Lys Glu Asp Ser Glu Trp Gln Ala Ser Leu Arg Lys Ser Lys 
225                 230                 235                 240 


Ala Ala Asp Glu Lys Arg Arg Ser Leu Ala Lys Gln Ala Arg Glu Asp 
                245                 250                 255     


Tyr Lys Arg Leu Ser Leu Gly Ala Gln Lys Gly Arg Gly Gly Glu Arg 
            260                 265                 270         


Leu Gln Ser Pro Leu Arg Val Pro Gln Lys Pro Glu Arg Pro Pro Leu 
        275                 280                 285             


Pro Pro Lys Pro Gln Phe Leu Asn Ser Gly Ala Tyr Pro Gln Lys Pro 
    290                 295                 300                 


Leu Arg Asn Gln Gly Val Val Arg Thr Leu Ser Ser Ser Ala Gln Glu 
305                 310                 315                 320 


Asp Ile Ile Arg Trp Phe Lys Glu Glu Gln Leu Pro Leu Arg Ala Gly 
                325                 330                 335     


Tyr Gln Lys Thr Ser Asp Thr Ile Ala Pro Trp Phe His Gly Ile Leu 
            340                 345                 350         


Thr Leu Lys Lys Ala Asn Glu Leu Leu Leu Ser Thr Gly Met Pro Gly 
        355                 360                 365             


Ser Phe Leu Ile Arg Val Ser Glu Arg Ile Lys Gly Tyr Ala Leu Ser 
    370                 375                 380                 


Tyr Leu Ser Glu Asp Gly Cys Lys His Phe Leu Ile Asp Ala Ser Ala 
385                 390                 395                 400 


Asp Ala Tyr Ser Phe Leu Gly Val Asp Gln Leu Gln His Ala Thr Leu 
                405                 410                 415     


Ala Asp Leu Val Glu Tyr His Lys Glu Glu Pro Ile Thr Ser Leu Gly 
            420                 425                 430         


Lys Glu Leu Leu Leu Tyr Pro Cys Gly Gln Gln Asp Gln Leu Pro Asp 
        435                 440                 445             


Tyr Leu Glu Leu Phe Glu 
    450                 


<210> 8517
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8517
Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
1               5                   10                  15      


Arg His Phe Asn Ala Pro Ser His Val Arg Arg Lys Ile Met Ser Ser 
            20                  25                  30          


Pro Leu Ser Lys Glu Leu Arg Gln Lys Tyr Asn Val Arg Ser Met Pro 
        35                  40                  45              


Ile Arg Lys Asp Asp Glu Val Gln Val Val Arg Gly His Tyr Lys Gly 
    50                  55                  60                  


Gln Gln Ile Gly Lys Val Val Gln Val Tyr Arg Lys Lys Tyr Val Ile 
65                  70                  75                  80  


Tyr Ile Glu Arg Val Gln Arg Glu Lys Ala Asn Gly Thr Thr Val His 
                85                  90                  95      


Val Gly Ile His Pro Ser Lys Val Val Ile Thr Arg Leu Lys Leu Asp 
            100                 105                 110         


Lys Asp Arg Lys Lys Ile Leu Glu Arg Lys Ala Lys Ser Arg Gln Val 
        115                 120                 125             


Gly Lys Glu Lys Gly Lys Tyr Lys Glu Glu Leu Ile Glu Lys Met Gln 
    130                 135                 140                 


Glu 
145 


<210> 8518
<211> 206
<212> PRT
<213> Homo sapiens

<400> 8518
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg Cys Thr Leu 
        115                 120                 125             


Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu Asn Val Glu 
    130                 135                 140                 


Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu Gln Arg Glu 
145                 150                 155                 160 


Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu Lys Leu Asp 
                165                 170                 175     


Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln Lys Thr Ala 
            180                 185                 190         


Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu Glu 
        195                 200                 205     


<210> 8519
<211> 349
<212> PRT
<213> Homo sapiens

<400> 8519
Met Glu Asp Pro Gln Ser Lys Glu Pro Ala Gly Glu Ala Val Ala Leu 
1               5                   10                  15      


Ala Leu Leu Glu Ser Pro Arg Pro Glu Gly Gly Glu Glu Pro Pro Arg 
            20                  25                  30          


Pro Ser Pro Glu Glu Thr Gln Gln Cys Lys Phe Asp Gly Gln Glu Thr 
        35                  40                  45              


Lys Gly Ser Lys Phe Ile Thr Ser Ser Ala Ser Asp Phe Ser Asp Pro 
    50                  55                  60                  


Val Tyr Lys Glu Ile Ala Ile Thr Asn Gly Cys Ile Asn Arg Met Ser 
65                  70                  75                  80  


Lys Glu Glu Leu Arg Ala Lys Leu Ser Glu Phe Lys Leu Glu Thr Arg 
                85                  90                  95      


Gly Val Lys Asp Val Leu Lys Lys Arg Leu Lys Asn Tyr Tyr Lys Lys 
            100                 105                 110         


Gln Lys Leu Met Leu Lys Glu Ser Asn Phe Ala Asp Ser Tyr Tyr Asp 
        115                 120                 125             


Tyr Ile Cys Ile Ile Asp Phe Glu Ala Thr Cys Glu Glu Gly Asn Pro 
    130                 135                 140                 


Pro Glu Phe Val His Glu Ile Ile Glu Phe Pro Val Val Leu Leu Asn 
145                 150                 155                 160 


Thr His Thr Leu Glu Ile Glu Asp Thr Phe Gln Gln Tyr Val Arg Pro 
                165                 170                 175     


Glu Ile Asn Thr Gln Leu Ser Asp Phe Cys Ile Ser Leu Thr Gly Ile 
            180                 185                 190         


Thr Gln Asp Gln Val Asp Arg Ala Asp Thr Phe Pro Gln Val Leu Lys 
        195                 200                 205             


Lys Val Ile Asp Trp Met Lys Leu Lys Glu Leu Gly Thr Lys Tyr Lys 
    210                 215                 220                 


Tyr Ser Leu Leu Thr Asp Gly Ser Trp Asp Met Ser Lys Phe Leu Asn 
225                 230                 235                 240 


Ile Gln Cys Gln Leu Ser Arg Leu Lys Tyr Pro Pro Phe Ala Lys Lys 
                245                 250                 255     


Trp Ile Asn Ile Arg Lys Ser Tyr Gly Asn Phe Tyr Lys Val Pro Arg 
            260                 265                 270         


Ser Gln Thr Lys Leu Thr Ile Met Leu Glu Lys Leu Gly Met Asp Tyr 
        275                 280                 285             


Asp Gly Arg Pro His Cys Gly Leu Asp Asp Ser Lys Asn Ile Ala Arg 
    290                 295                 300                 


Ile Ala Val Arg Met Leu Gln Asp Gly Cys Glu Leu Arg Ile Asn Glu 
305                 310                 315                 320 


Lys Met His Ala Gly Gln Leu Met Ser Val Ser Ser Ser Leu Pro Ile 
                325                 330                 335     


Glu Gly Thr Pro Pro Pro Gln Met Pro His Phe Arg Lys 
            340                 345                 


<210> 8520
<211> 142
<212> PRT
<213> Homo sapiens

<400> 8520
Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30          


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45              


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60                  


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80  


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95      


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110         


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125             


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys 
    130                 135                 140         


<210> 8521
<211> 124
<212> PRT
<213> Homo sapiens

<400> 8521
Met Ser Ala Thr Val Val Asp Ala Val Asn Ala Ala Pro Leu Ser Gly 
1               5                   10                  15      


Ser Lys Glu Met Ser Leu Glu Glu Pro Lys Lys Met Thr Arg Glu Asp 
            20                  25                  30          


Trp Arg Lys Lys Lys Glu Leu Glu Glu Gln Arg Lys Leu Gly Asn Ala 
        35                  40                  45              


Pro Ala Glu Val Asp Glu Glu Gly Lys Asp Ile Asn Pro His Ile Pro 
    50                  55                  60                  


Gln Tyr Ile Ser Ser Val Pro Trp Tyr Ile Asp Pro Ser Lys Arg Pro 
65                  70                  75                  80  


Thr Leu Lys His Gln Arg Pro Gln Pro Glu Lys Gln Lys Gln Phe Ser 
                85                  90                  95      


Ser Ser Gly Glu Trp Tyr Lys Arg Gly Val Lys Glu Asn Ser Ile Ile 
            100                 105                 110         


Thr Lys Tyr Arg Lys Gly Ala Cys Glu Asn Cys Gly 
        115                 120                 


<210> 8522
<211> 249
<212> PRT
<213> Homo sapiens

<400> 8522
Met Val Asp Arg Leu Ala Asn Ser Glu Ala Asn Thr Arg Arg Ile Ser 
1               5                   10                  15      


Ile Val Glu Asn Cys Phe Gly Ala Ala Gly Gln Pro Leu Thr Ile Pro 
            20                  25                  30          


Gly Arg Val Leu Ile Gly Glu Gly Val Leu Thr Lys Leu Cys Arg Lys 
        35                  40                  45              


Lys Pro Lys Ala Arg Gln Phe Phe Leu Phe Asn Asp Ile Leu Val Tyr 
    50                  55                  60                  


Gly Asn Ile Val Ile Gln Lys Lys Lys Tyr Asn Lys Gln His Ile Ile 
65                  70                  75                  80  


Pro Leu Glu Asn Val Thr Ile Asp Ser Ile Lys Asp Glu Gly Asp Leu 
                85                  90                  95      


Arg Asn Gly Trp Leu Ile Lys Thr Pro Thr Lys Ser Phe Ala Val Tyr 
            100                 105                 110         


Ala Ala Thr Ala Thr Glu Lys Ser Glu Trp Met Asn His Ile Asn Lys 
        115                 120                 125             


Cys Val Thr Asp Leu Leu Ser Lys Ser Gly Lys Thr Pro Ser Asn Glu 
    130                 135                 140                 


His Ala Ala Val Trp Val Pro Asp Ser Glu Ala Thr Val Cys Met Arg 
145                 150                 155                 160 


Cys Gln Lys Ala Lys Phe Thr Pro Val Asn Arg Arg His His Cys Arg 
                165                 170                 175     


Lys Cys Gly Phe Val Val Cys Gly Pro Cys Ser Glu Lys Arg Phe Leu 
            180                 185                 190         


Leu Pro Ser Gln Ser Ser Lys Pro Val Arg Ile Cys Asp Phe Cys Tyr 
        195                 200                 205             


Asp Leu Leu Ser Ala Gly Asp Met Ala Thr Cys Gln Pro Ala Arg Ser 
    210                 215                 220                 


Asp Ser Tyr Ser Gln Ser Leu Lys Ser Pro Leu Asn Asp Met Ser Asp 
225                 230                 235                 240 


Asp Asp Asp Asp Asp Asp Ser Ser Asp 
                245                 


<210> 8523
<211> 39
<212> PRT
<213> Homo sapiens

<400> 8523
Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
1               5                   10                  15      


Arg His Phe Asn Ala Pro Ser His Val Arg Arg Lys Ile Met Ser Ser 
            20                  25                  30          


Pro Leu Ser Lys Glu Leu Arg 
        35                  


<210> 8524
<211> 466
<212> PRT
<213> Homo sapiens

<400> 8524
Met Gly Trp Ile Thr Glu Asp Leu Ile Arg Arg Asn Ala Glu His Asn 
1               5                   10                  15      


Asp Cys Val Ile Phe Ser Leu Glu Glu Leu Ser Leu His Gln Gln Glu 
            20                  25                  30          


Ile Glu Arg Leu Glu His Ile Asp Lys Trp Cys Arg Asp Leu Lys Ile 
        35                  40                  45              


Leu Tyr Leu Gln Asn Asn Leu Ile Gly Lys Ile Glu Asn Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Leu Glu Tyr Leu Asn Leu Ala Leu Asn Asn Ile Glu Lys 
65                  70                  75                  80  


Ile Glu Asn Leu Glu Gly Cys Glu Glu Leu Ala Lys Leu Asp Leu Thr 
                85                  90                  95      


Val Asn Phe Ile Gly Glu Leu Ser Ser Ile Lys Asn Leu Gln His Asn 
            100                 105                 110         


Ile His Leu Lys Glu Leu Phe Leu Met Gly Asn Pro Cys Ala Ser Phe 
        115                 120                 125             


Asp His Tyr Arg Glu Phe Val Val Ala Thr Leu Pro Gln Leu Lys Trp 
    130                 135                 140                 


Leu Asp Gly Lys Glu Ile Glu Pro Ser Glu Arg Ile Lys Ala Leu Gln 
145                 150                 155                 160 


Asp Tyr Ser Val Ile Glu Pro Gln Ile Arg Glu Gln Glu Lys Asp His 
                165                 170                 175     


Cys Leu Lys Arg Ala Lys Leu Lys Glu Glu Ala Gln Arg Lys His Gln 
            180                 185                 190         


Glu Glu Asp Lys Asn Glu Asp Lys Arg Ser Asn Ala Gly Phe Asp Gly 
        195                 200                 205             


Arg Trp Tyr Thr Asp Ile Asn Ala Thr Leu Ser Ser Leu Glu Ser Lys 
    210                 215                 220                 


Asp His Leu Gln Ala Pro Asp Thr Glu Glu His Asn Thr Lys Lys Leu 
225                 230                 235                 240 


Asp Asn Ser Glu Asp Asp Leu Glu Phe Trp Asn Lys Pro Cys Leu Phe 
                245                 250                 255     


Thr Pro Glu Ser Arg Leu Glu Thr Leu Arg His Met Glu Lys Gln Arg 
            260                 265                 270         


Lys Lys Gln Glu Lys Leu Ser Glu Lys Lys Lys Lys Val Lys Pro Pro 
        275                 280                 285             


Arg Thr Leu Ile Thr Glu Asp Gly Lys Ala Leu Asn Val Asn Glu Pro 
    290                 295                 300                 


Lys Ile Asp Phe Ser Leu Lys Asp Asn Glu Lys Gln Ile Ile Leu Asp 
305                 310                 315                 320 


Leu Ala Val Tyr Arg Tyr Met Asp Thr Ser Leu Ile Asp Val Asp Val 
                325                 330                 335     


Gln Pro Thr Tyr Val Arg Val Met Ile Lys Gly Lys Pro Phe Gln Leu 
            340                 345                 350         


Val Leu Pro Ala Glu Val Lys Pro Asp Ser Ser Ser Ala Lys Arg Ser 
        355                 360                 365             


Gln Thr Thr Gly His Leu Val Ile Cys Met Pro Lys Val Gly Glu Val 
    370                 375                 380                 


Ile Thr Gly Gly Gln Arg Ala Phe Lys Ser Met Lys Thr Thr Ser Asp 
385                 390                 395                 400 


Arg Ser Arg Glu Gln Thr Asn Thr Arg Ser Lys His Met Glu Lys Leu 
                405                 410                 415     


Glu Val Asp Pro Ser Lys His Ser Phe Pro Asp Val Thr Asn Ile Val 
            420                 425                 430         


Gln Glu Lys Lys His Thr Pro Arg Arg Arg Pro Glu Pro Lys Ile Ile 
        435                 440                 445             


Pro Ser Glu Glu Asp Pro Thr Phe Glu Asp Asn Pro Glu Val Pro Pro 
    450                 455                 460                 


Leu Ile 
465     


<210> 8525
<211> 175
<212> PRT
<213> Homo sapiens

<400> 8525
Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser Val 
        115                 120                 125             


Tyr Leu Ser Tyr Glu Lys Arg Ala Glu Thr Leu Ala Val Glu Ile Lys 
    130                 135                 140                 


Glu Leu Gln Gly Gln Leu Ala Asp Tyr Asn Met Leu Val Asp Lys Leu 
145                 150                 155                 160 


Asn Thr Asn Thr Glu Met Glu Glu Val Met Asn Asp Tyr Asn Met 
                165                 170                 175 


<210> 8526
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8526
Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
1               5                   10                  15      


Arg His Phe Asn Ala Pro Ser His Val Arg Arg Lys Ile Met Ser Ser 
            20                  25                  30          


Pro Leu Ser Lys Glu Leu Arg Gln Lys Tyr Asn Val Arg Ser Met Pro 
        35                  40                  45              


Ile Arg Lys Asp Asp Glu Val Gln Val Val Arg Gly His Tyr Lys Gly 
    50                  55                  60                  


Gln Gln Ile Gly Lys Val Val Gln Val Tyr Arg Lys Lys Tyr Val Ile 
65                  70                  75                  80  


Tyr Ile Glu Arg Val Gln Arg Glu Lys Ala Asn Gly Thr Thr Val His 
                85                  90                  95      


Val Gly Ile His Pro Ser Lys Val Val Ile Thr Arg Leu Lys Leu Asp 
            100                 105                 110         


Lys Asp Arg Lys Lys Ile Leu Glu Arg Lys Ala Lys Ser Arg Gln Val 
        115                 120                 125             


Gly Lys Glu Lys Gly Lys Tyr Lys Glu Glu Leu Ile Glu Lys Met Gln 
    130                 135                 140                 


Glu 
145 


<210> 8527
<211> 711
<212> PRT
<213> Homo sapiens

<400> 8527
Met Ser Ser Val Gln Ser Gln Gln Glu Gln Leu Ser Gln Ser Asp Pro 
1               5                   10                  15      


Ser Pro Ser Pro Asn Ser Cys Ser Ser Phe Glu Leu Ile Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Leu Tyr Glu Pro Val Ser Pro His Trp Phe Tyr Cys Lys 
        35                  40                  45              


Ile Ile Asp Ser Lys Glu Thr Trp Ile Pro Phe Asn Ser Glu Asp Ser 
    50                  55                  60                  


Gln Gln Leu Glu Glu Ala Tyr Ser Ser Gly Lys Gly Cys Asn Gly Arg 
65                  70                  75                  80  


Val Val Pro Thr Asp Gly Gly Arg Tyr Asp Val His Leu Gly Glu Arg 
                85                  90                  95      


Met Arg Tyr Ala Val Tyr Trp Asp Glu Leu Ala Ser Glu Val Arg Arg 
            100                 105                 110         


Cys Thr Trp Phe Tyr Lys Gly Asp Lys Asp Asn Lys Tyr Val Pro Tyr 
        115                 120                 125             


Ser Glu Ser Phe Ser Gln Val Leu Glu Glu Thr Tyr Met Leu Ala Val 
    130                 135                 140                 


Thr Leu Asp Glu Trp Lys Lys Lys Leu Glu Ser Pro Asn Arg Glu Ile 
145                 150                 155                 160 


Ile Ile Leu His Asn Pro Lys Leu Met Val His Tyr Gln Pro Val Ala 
                165                 170                 175     


Gly Ser Asp Asp Trp Gly Ser Thr Pro Thr Glu Gln Gly Arg Pro Arg 
            180                 185                 190         


Thr Val Lys Arg Gly Val Glu Asn Ile Ser Val Asp Ile His Cys Gly 
        195                 200                 205             


Glu Pro Leu Gln Ile Asp His Leu Val Phe Val Val His Gly Ile Gly 
    210                 215                 220                 


Pro Ala Cys Asp Leu Arg Phe Arg Ser Ile Val Gln Cys Val Asn Asp 
225                 230                 235                 240 


Phe Arg Ser Val Ser Leu Asn Leu Leu Gln Thr His Phe Lys Lys Ala 
                245                 250                 255     


Gln Glu Asn Gln Gln Ile Gly Arg Val Glu Phe Leu Pro Val Asn Trp 
            260                 265                 270         


His Ser Pro Leu His Ser Thr Gly Val Asp Val Asp Leu Gln Arg Ile 
        275                 280                 285             


Thr Leu Pro Ser Ile Asn Arg Leu Arg His Phe Thr Asn Asp Thr Ile 
    290                 295                 300                 


Leu Asp Val Phe Phe Tyr Asn Ser Pro Thr Tyr Cys Gln Thr Ile Val 
305                 310                 315                 320 


Asp Thr Val Ala Ser Glu Met Asn Arg Ile Tyr Thr Leu Phe Leu Gln 
                325                 330                 335     


Arg Asn Pro Asp Phe Lys Gly Gly Val Ser Ile Ala Gly His Ser Leu 
            340                 345                 350         


Gly Ser Leu Ile Leu Phe Asp Ile Leu Thr Asn Gln Lys Asp Ser Leu 
        355                 360                 365             


Gly Asp Ile Asp Ser Glu Lys Asp Ser Leu Asn Ile Val Met Asp Gln 
    370                 375                 380                 


Gly Asp Thr Pro Thr Leu Glu Glu Asp Leu Lys Lys Leu Gln Leu Ser 
385                 390                 395                 400 


Glu Phe Phe Asp Ile Phe Glu Lys Glu Lys Val Asp Lys Glu Ala Leu 
                405                 410                 415     


Ala Leu Cys Thr Asp Arg Asp Leu Gln Glu Ile Gly Ile Pro Leu Gly 
            420                 425                 430         


Pro Arg Lys Lys Ile Leu Asn Tyr Phe Ser Thr Arg Lys Asn Ser Met 
        435                 440                 445             


Gly Ile Lys Arg Pro Ala Pro Gln Pro Ala Ser Gly Ala Asn Ile Pro 
    450                 455                 460                 


Lys Glu Ser Glu Phe Cys Ser Ser Ser Asn Thr Arg Asn Gly Asp Tyr 
465                 470                 475                 480 


Leu Asp Val Gly Ile Gly Gln Val Ser Val Lys Tyr Pro Arg Leu Ile 
                485                 490                 495     


Tyr Lys Pro Glu Ile Phe Phe Ala Phe Gly Ser Pro Ile Gly Met Phe 
            500                 505                 510         


Leu Thr Val Arg Gly Leu Lys Arg Ile Asp Pro Asn Tyr Arg Phe Pro 
        515                 520                 525             


Thr Cys Lys Gly Phe Phe Asn Ile Tyr His Pro Phe Asp Pro Val Ala 
    530                 535                 540                 


Tyr Arg Ile Glu Pro Met Val Val Pro Gly Val Glu Phe Glu Pro Met 
545                 550                 555                 560 


Leu Ile Pro His His Lys Gly Arg Lys Arg Met His Leu Glu Leu Arg 
                565                 570                 575     


Glu Gly Leu Thr Arg Met Ser Met Asp Leu Lys Asn Asn Leu Leu Gly 
            580                 585                 590         


Ser Leu Arg Met Ala Trp Lys Ser Phe Thr Arg Ala Pro Tyr Pro Ala 
        595                 600                 605             


Leu Gln Ala Ser Glu Thr Pro Glu Glu Thr Glu Ala Glu Pro Glu Ser 
    610                 615                 620                 


Thr Ser Glu Lys Pro Ser Asp Val Asn Thr Glu Glu Thr Ser Val Ala 
625                 630                 635                 640 


Val Lys Glu Glu Val Leu Pro Ile Asn Val Gly Met Leu Asn Gly Gly 
                645                 650                 655     


Gln Arg Ile Asp Tyr Val Leu Gln Glu Lys Pro Ile Glu Ser Phe Asn 
            660                 665                 670         


Glu Tyr Leu Phe Ala Leu Gln Ser His Leu Cys Tyr Trp Glu Ser Glu 
        675                 680                 685             


Asp Thr Val Leu Leu Val Leu Lys Glu Ile Tyr Gln Thr Gln Gly Ile 
    690                 695                 700                 


Phe Leu Asp Gln Pro Leu Gln 
705                 710     


<210> 8528
<211> 156
<212> PRT
<213> Homo sapiens

<400> 8528
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr Thr 
        35                  40                  45              


Ser Asp Asp Thr Pro Cys Gln Glu Gln Pro Lys Glu Val Leu Lys Ala 
    50                  55                  60                  


Pro Ser Thr Ser Gly Leu Gln Gln Val Ala Phe Gln Pro Gly Gln Lys 
65                  70                  75                  80  


Val Tyr Val Trp Tyr Gly Gly Gln Glu Cys Thr Gly Leu Val Glu Gln 
                85                  90                  95      


His Ser Trp Met Glu Gly Gln Val Thr Val Trp Leu Leu Glu Gln Lys 
            100                 105                 110         


Leu Gln Val Cys Cys Arg Val Glu Glu Val Trp Leu Ala Glu Leu Gln 
        115                 120                 125             


Gly Pro Cys Pro Gln Ala Pro Pro Leu Glu Pro Gly Ala Gln Ala Leu 
    130                 135                 140                 


Ala Tyr Arg Pro Val Ser Arg Asn Ile Asp Val Pro 
145                 150                 155     


<210> 8529
<211> 102
<212> PRT
<213> Homo sapiens

<400> 8529
Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30          


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45              


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60                  


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80  


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95      


Gln Gly Thr Leu Phe Glu 
            100         


<210> 8530
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8530
Met Ala Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala 
1               5                   10                  15      


Thr Phe Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Trp Pro Cys Lys Ile Val Glu Met Ser Ala Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Pro Glu Asp Leu 
            100                 105                 110         


Arg Leu Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp 
        115                 120                 125             


Cys Gly Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu 
    130                 135                 140                 


Ala Ala Val Ala Ile Lys Ala Met Ala Lys 
145                 150                 


<210> 8531
<211> 101
<212> PRT
<213> Homo sapiens

<400> 8531
Met Ser Ala Thr Val Val Asp Ala Val Asn Ala Ala Pro Leu Ser Gly 
1               5                   10                  15      


Ser Lys Glu Met Ser Leu Glu Glu Pro Lys Lys Met Thr Arg Glu Asp 
            20                  25                  30          


Trp Arg Lys Lys Lys Glu Leu Glu Glu Gln Arg Lys Leu Gly Asn Ala 
        35                  40                  45              


Pro Ala Glu Val Asp Glu Glu Gly Lys Asp Ile Asn Pro His Ile Pro 
    50                  55                  60                  


Gln Tyr Ile Ser Ser Val Pro Trp Tyr Ile Asp Pro Ser Lys Arg Pro 
65                  70                  75                  80  


Thr Leu Lys His Gln Arg Pro Gln Pro Glu Lys Gln Lys Gln Phe Ser 
                85                  90                  95      


Ser Ser Gly Glu Trp 
            100     


<210> 8532
<211> 1066
<212> PRT
<213> Homo sapiens

<400> 8532
Met Ala Gly Ala Leu Arg Arg Gly Arg Ala Leu Gly Ser Arg Pro Ser 
1               5                   10                  15      


Gly Pro Thr Val Ser Ser Arg Arg Ser Pro Gln Cys Pro Val Ala Gln 
            20                  25                  30          


Glu Gly Leu Gly Ala Arg Ser Arg Pro Arg Val Ala Pro Arg Ser Leu 
        35                  40                  45              


Ala Arg Cys Gly Pro Ser Ser Arg Leu Met Gly Trp Lys Pro Ser Glu 
    50                  55                  60                  


Ala Arg Gly Gln Ser Gln Ser Phe Gln Ala Ser Gly Leu Gln Pro Arg 
65                  70                  75                  80  


Ser Leu Lys Ala Ala Arg Arg Ala Thr Gly Arg Pro Asp Arg Ser Arg 
                85                  90                  95      


Ala Ala Arg Pro Thr Met Asp Pro Ser Ala His Arg Ser Arg Ala Ala 
            100                 105                 110         


Pro Pro Asn Met Asp Pro Asp Pro Gln Ala Gly Val Gln Val Gly Met 
        115                 120                 125             


Arg Val Val Arg Gly Val Asp Trp Lys Trp Gly Gln Gln Asp Gly Gly 
    130                 135                 140                 


Glu Gly Gly Val Gly Thr Val Val Glu Leu Gly Arg His Gly Ser Pro 
145                 150                 155                 160 


Ser Thr Pro Asp Arg Thr Val Val Val Gln Trp Asp Gln Gly Thr Arg 
                165                 170                 175     


Thr Asn Tyr Arg Ala Gly Tyr Gln Gly Ala His Asp Leu Leu Leu Tyr 
            180                 185                 190         


Asp Asn Ala Gln Ile Gly Val Arg His Pro Asn Ile Ile Cys Asp Cys 
        195                 200                 205             


Cys Lys Lys His Gly Leu Arg Gly Met Arg Trp Lys Cys Arg Val Cys 
    210                 215                 220                 


Leu Asp Tyr Asp Leu Cys Thr Gln Cys Tyr Met His Asn Lys His Glu 
225                 230                 235                 240 


Leu Ala His Ala Phe Asp Arg Tyr Glu Thr Ala His Ser Arg Pro Val 
                245                 250                 255     


Thr Leu Ser Pro Arg Gln Gly Leu Pro Arg Ile Pro Leu Arg Gly Ile 
            260                 265                 270         


Phe Gln Gly Ala Lys Val Val Arg Gly Pro Asp Trp Glu Trp Gly Ser 
        275                 280                 285             


Gln Asp Gly Gly Glu Gly Lys Pro Gly Arg Val Val Asp Ile Arg Gly 
    290                 295                 300                 


Trp Asp Val Glu Thr Gly Arg Ser Val Ala Ser Val Thr Trp Ala Asp 
305                 310                 315                 320 


Gly Thr Thr Asn Val Tyr Arg Val Gly His Lys Gly Lys Val Asp Leu 
                325                 330                 335     


Lys Cys Val Gly Glu Ala Ala Gly Gly Phe Tyr Tyr Lys Asp His Leu 
            340                 345                 350         


Pro Arg Leu Gly Lys Pro Ala Glu Leu Gln Arg Arg Val Ser Ala Asp 
        355                 360                 365             


Ser Gln Pro Phe Gln His Gly Asp Lys Val Lys Cys Leu Leu Asp Thr 
    370                 375                 380                 


Asp Val Leu Arg Glu Met Gln Glu Gly His Gly Gly Trp Asn Pro Arg 
385                 390                 395                 400 


Met Ala Glu Thr Gly Thr Val His Arg Ile Thr Asp Arg Gly Asp Val 
                405                 410                 415     


Arg Val Gln Phe Asn His Glu Thr Arg Trp Thr Phe His Pro Gly Ala 
            420                 425                 430         


Leu Thr Lys His His Ser Phe Trp Val Gly Asp Val Val Arg Val Ile 
        435                 440                 445             


Gly Asp Leu Asp Thr Val Lys Arg Leu Gln Ala Gly His Gly Glu Trp 
    450                 455                 460                 


Thr Asp Asp Met Ala Pro Ala Leu Gly Arg Val Gly Lys Val Val Lys 
465                 470                 475                 480 


Val Phe Gly Asp Gly Asn Leu Arg Val Ala Val Ala Gly Gln Arg Trp 
                485                 490                 495     


Thr Phe Ser Pro Ser Cys Leu Val Ala Tyr Arg Pro Glu Glu Asp Ala 
            500                 505                 510         


Asn Leu Asp Val Ala Glu Arg Ala Arg Glu Asn Lys Ser Ser Leu Ser 
        515                 520                 525             


Val Ala Leu Asp Lys Leu Arg Ala Gln Lys Ser Asp Pro Glu His Pro 
    530                 535                 540                 


Gly Arg Leu Val Val Glu Val Ala Leu Gly Asn Ala Ala Arg Ala Leu 
545                 550                 555                 560 


Asp Leu Leu Arg Arg Arg Pro Glu Gln Val Asp Thr Lys Asn Gln Gly 
                565                 570                 575     


Arg Thr Ala Leu Gln Val Ala Ala Tyr Leu Gly Gln Val Glu Leu Ile 
            580                 585                 590         


Arg Leu Leu Leu Gln Ala Arg Ala Gly Val Asp Leu Pro Asp Asp Glu 
        595                 600                 605             


Gly Asn Thr Ala Leu His Tyr Ala Ala Leu Gly Asn Gln Pro Glu Ala 
    610                 615                 620                 


Thr Arg Val Leu Leu Ser Ala Gly Cys Arg Ala Asp Ala Ile Asn Ser 
625                 630                 635                 640 


Thr Gln Ser Thr Ala Leu His Val Ala Val Gln Arg Gly Phe Leu Glu 
                645                 650                 655     


Val Val Arg Ala Leu Cys Glu Arg Gly Cys Asp Val Asn Leu Pro Asp 
            660                 665                 670         


Ala His Ser Asp Thr Pro Leu His Ser Ala Ile Ser Ala Gly Thr Gly 
        675                 680                 685             


Ala Ser Gly Ile Val Glu Val Leu Thr Glu Val Pro Asn Ile Asp Val 
    690                 695                 700                 


Thr Ala Thr Asn Ser Gln Gly Phe Thr Leu Leu His His Ala Ser Leu 
705                 710                 715                 720 


Lys Gly His Ala Leu Ala Val Arg Lys Ile Leu Ala Arg Ala Arg Gln 
                725                 730                 735     


Leu Val Asp Ala Lys Lys Glu Asp Gly Phe Thr Ala Leu His Leu Ala 
            740                 745                 750         


Ala Leu Asn Asn His Arg Glu Val Ala Gln Ile Leu Ile Arg Glu Gly 
        755                 760                 765             


Arg Cys Asp Val Asn Val Arg Asn Arg Lys Leu Gln Ser Pro Leu His 
    770                 775                 780                 


Leu Ala Val Gln Gln Ala His Val Gly Leu Val Pro Leu Leu Val Asp 
785                 790                 795                 800 


Ala Gly Cys Ser Val Asn Ala Glu Asp Glu Glu Gly Asp Thr Ala Leu 
                805                 810                 815     


His Val Ala Leu Gln Arg His Gln Leu Leu Pro Leu Val Ala Asp Gly 
            820                 825                 830         


Ala Gly Gly Asp Pro Gly Pro Leu Gln Leu Leu Ser Arg Leu Gln Ala 
        835                 840                 845             


Ser Gly Leu Pro Gly Ser Ala Glu Leu Thr Val Gly Ala Ala Val Ala 
    850                 855                 860                 


Cys Phe Leu Ala Leu Glu Gly Ala Asp Val Ser Tyr Thr Asn His Arg 
865                 870                 875                 880 


Gly Arg Ser Pro Leu Asp Leu Ala Ala Glu Gly Arg Val Leu Lys Ala 
                885                 890                 895     


Leu Gln Gly Cys Ala Gln Arg Phe Arg Glu Arg Gln Ala Gly Gly Gly 
            900                 905                 910         


Ala Ala Pro Gly Pro Arg Gln Thr Leu Gly Thr Pro Asn Thr Val Thr 
        915                 920                 925             


Asn Leu His Val Gly Ala Ala Pro Gly Pro Glu Ala Ala Glu Cys Leu 
    930                 935                 940                 


Val Cys Ser Glu Leu Ala Leu Leu Val Leu Phe Ser Pro Cys Gln His 
945                 950                 955                 960 


Arg Thr Val Cys Glu Glu Cys Ala Arg Arg Met Lys Lys Cys Ile Arg 
                965                 970                 975     


Cys Gln Val Val Val Ser Lys Lys Leu Arg Pro Asp Gly Ser Glu Val 
            980                 985                 990         


Ala Ser Ala Ala Pro Ala Pro Gly  Pro Pro Arg Gln Leu  Val Glu Glu 
        995                 1000                 1005             


Leu Gln  Ser Arg Tyr Arg Gln  Met Glu Glu Arg Ile  Thr Cys Pro 
    1010                 1015                 1020             


Ile Cys  Ile Asp Ser His Ile  Arg Leu Val Phe Gln  Cys Gly His 
    1025                 1030                 1035             


Gly Ala  Cys Ala Pro Cys Gly  Ser Ala Leu Ser Ala  Cys Pro Ile 
    1040                 1045                 1050             


Cys Arg  Gln Pro Ile Arg Asp  Arg Ile Gln Ile Phe  Val 
    1055                 1060                 1065     


<210> 8533
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8533
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu 
        115 


<210> 8534
<211> 124
<212> PRT
<213> Homo sapiens

<400> 8534
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr Thr 
        35                  40                  45              


Ser Asp Asp Thr Pro Cys Gln Glu Gln Pro Lys Glu Val Leu Lys Ala 
    50                  55                  60                  


Pro Ser Thr Ser Gly Leu Gln Gln Val Ala Phe Gln Pro Gly Gln Lys 
65                  70                  75                  80  


Val Tyr Val Trp Tyr Gly Gly Gln Glu Cys Thr Gly Leu Val Glu Gln 
                85                  90                  95      


His Ser Trp Met Glu Gly Gln Val Thr Val Trp Leu Leu Glu Gln Lys 
            100                 105                 110         


Leu Gln Val Cys Cys Arg Val Glu Glu Val Trp Leu 
        115                 120                 


<210> 8535
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8535
Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
1               5                   10                  15      


Arg His Phe Asn Ala Pro Ser His Val Arg Arg Lys Ile Met Ser Ser 
            20                  25                  30          


Pro Leu Ser Lys Glu Leu Arg Gln Lys Tyr Asn Val Arg Ser Met Pro 
        35                  40                  45              


Ile Arg Lys Asp Asp Glu Val Gln Val Val Arg Gly His Tyr Lys Gly 
    50                  55                  60                  


Gln Gln Ile Gly Lys Val Val Gln Val Tyr Arg Lys Lys Tyr Val Ile 
65                  70                  75                  80  


Tyr Ile Glu Arg Val Gln Arg Glu Lys Ala Asn Gly Thr Thr Val His 
                85                  90                  95      


Val Gly Ile His Pro Ser Lys Val Val Ile Thr Arg Leu Lys Leu Asp 
            100                 105                 110         


Lys Asp Arg Lys Lys Ile Leu Glu Arg Lys Ala Lys Ser Arg Gln Val 
        115                 120                 125             


Gly Lys Glu Lys Gly Lys Tyr Lys Glu Glu Leu Ile Glu Lys Met Gln 
    130                 135                 140                 


Glu 
145 


<210> 8536
<211> 112
<212> PRT
<213> Homo sapiens

<400> 8536
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


<210> 8537
<211> 114
<212> PRT
<213> Homo sapiens

<400> 8537
Met Pro Ser Ala Glu Ala Lys Leu Lys Lys Asn Arg Cys Ala Asn Cys 
1               5                   10                  15      


Phe Asp Cys Pro Gly Cys Met His Thr Leu Ser Thr Arg Ala Thr Ser 
            20                  25                  30          


Ile Ser Thr Gln Leu Pro Asp Asp Pro Ala Lys Thr Thr Met Lys Lys 
        35                  40                  45              


Ala Tyr Tyr Leu Ala Cys Gly Phe Cys Arg Trp Thr Ser Arg Asp Val 
    50                  55                  60                  


Gly Met Ala Asp Lys Ser Val Ala Ser Gly Gly Trp Gln Glu Pro Glu 
65                  70                  75                  80  


Asn Pro His Thr Gln Arg Met Asn Lys Leu Ile Glu Tyr Tyr Gln Gln 
                85                  90                  95      


Leu Ala Gln Lys Glu Lys Val Glu Arg Asp Arg Lys Lys Leu Ala Arg 
            100                 105                 110         


Arg Arg 
        


<210> 8538
<211> 215
<212> PRT
<213> Homo sapiens

<400> 8538
Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 
1               5                   10                  15      


Pro Gln Ser Gln Ala Glu Thr Gly Ser Gly Thr Ala Ser Asp Ser Gly 
            20                  25                  30          


Glu Ser Val Pro Gly Ile Glu Glu Gln Asp Ser Thr Gln Thr Thr Thr 
        35                  40                  45              


Gln Lys Ala Trp Leu Val Ala Ala Ala Glu Ile Asp Glu Glu Pro Val 
    50                  55                  60                  


Gly Lys Ala Lys Gln Ser Arg Ser Glu Lys Arg Ala Arg Lys Ala Met 
65                  70                  75                  80  


Ser Lys Leu Gly Leu Leu Gln Val Thr Gly Val Thr Arg Val Thr Ile 
                85                  90                  95      


Trp Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Leu Asp Val Tyr 
            100                 105                 110         


Lys Ser Pro Ala Ser Asp Ala Tyr Ile Val Phe Gly Glu Ala Lys Ile 
        115                 120                 125             


Gln Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Arg 
    130                 135                 140                 


Val Gln Gly Glu Ala Val Gly Asn Ile Gln Glu Asn Thr Gln Thr Pro 
145                 150                 155                 160 


Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val 
                165                 170                 175     


Glu Val Lys Asp Val Lys Leu Val Met Ser Gln Ala Asn Val Ser Arg 
            180                 185                 190         


Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn 
        195                 200                 205             


Ala Ile Met Glu Leu Thr Val 
    210                 215 


<210> 8539
<211> 143
<212> PRT
<213> Homo sapiens

<400> 8539
Met Ser Ala Thr Val Val Asp Ala Val Asn Ala Ala Pro Leu Ser Gly 
1               5                   10                  15      


Ser Lys Glu Met Ser Leu Glu Glu Pro Lys Lys Met Thr Arg Glu Asp 
            20                  25                  30          


Trp Arg Lys Lys Lys Glu Leu Glu Glu Gln Arg Lys Leu Gly Asn Ala 
        35                  40                  45              


Pro Ala Glu Val Asp Glu Glu Gly Lys Asp Ile Asn Pro His Ile Pro 
    50                  55                  60                  


Gln Tyr Ile Ser Ser Val Pro Trp Tyr Ile Asp Pro Ser Lys Arg Pro 
65                  70                  75                  80  


Thr Leu Lys His Gln Arg Pro Gln Pro Glu Lys Gln Lys Gln Phe Ser 
                85                  90                  95      


Ser Ser Gly Glu Trp Tyr Lys Arg Gly Val Lys Glu Asn Ser Ile Ile 
            100                 105                 110         


Thr Lys Tyr Arg Lys Gly Ala Cys Glu Asn Cys Gly Ala Met Thr His 
        115                 120                 125             


Lys Lys Lys Asp Cys Phe Glu Arg Pro Arg Arg Val Gly Ala Lys 
    130                 135                 140             


<210> 8540
<211> 188
<212> PRT
<213> Homo sapiens

<400> 8540
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr Thr 
        35                  40                  45              


Ser Asp Asp Thr Pro Cys Gln Glu Gln Pro Lys Glu Val Leu Lys Ala 
    50                  55                  60                  


Pro Ser Thr Ser Gly Leu Gln Gln Val Ala Phe Gln Pro Gly Gln Lys 
65                  70                  75                  80  


Val Tyr Val Trp Tyr Gly Gly Gln Glu Cys Thr Gly Leu Val Glu Gln 
                85                  90                  95      


His Ser Trp Met Glu Gly Gln Val Thr Val Trp Leu Leu Glu Gln Lys 
            100                 105                 110         


Leu Gln Val Cys Cys Arg Val Glu Glu Val Trp Leu Ala Glu Leu Gln 
        115                 120                 125             


Gly Pro Cys Pro Gln Ala Pro Pro Leu Glu Pro Gly Ala Gln Ala Leu 
    130                 135                 140                 


Ala Tyr Arg Pro Val Ser Arg Asn Ile Asp Val Pro Lys Arg Lys Ser 
145                 150                 155                 160 


Asp Ala Val Glu Met Asp Glu Met Met Ala Ala Met Val Leu Thr Ser 
                165                 170                 175     


Leu Ser Cys Ser Pro Val Val Gln Ser Pro Pro Gly 
            180                 185             


<210> 8541
<211> 28
<212> PRT
<213> Homo sapiens

<400> 8541
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln 
            20                  25              


<210> 8542
<211> 28
<212> PRT
<213> Homo sapiens

<400> 8542
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn 
            20                  25              


<210> 8543
<211> 357
<212> PRT
<213> Homo sapiens

<400> 8543
Met Gly Gly Ala Val Ser Ala Gly Glu Asp Asn Asp Asp Leu Ile Asp 
1               5                   10                  15      


Asn Leu Lys Glu Ala Gln Tyr Ile Arg Thr Glu Arg Val Glu Gln Ala 
            20                  25                  30          


Phe Arg Ala Ile Asp Arg Gly Asp Tyr Tyr Leu Glu Gly Tyr Arg Asp 
        35                  40                  45              


Asn Ala Tyr Lys Asp Leu Ala Trp Lys His Gly Asn Ile His Leu Ser 
    50                  55                  60                  


Ala Pro Cys Ile Tyr Ser Glu Val Met Glu Ala Leu Lys Leu Gln Pro 
65                  70                  75                  80  


Gly Leu Ser Phe Leu Asn Leu Gly Ser Gly Thr Gly Tyr Leu Ser Thr 
                85                  90                  95      


Met Val Gly Leu Ile Leu Gly Pro Phe Gly Ile Asn His Gly Ile Glu 
            100                 105                 110         


Leu His Ser Asp Val Val Glu Tyr Ala Lys Glu Lys Leu Glu Ser Phe 
        115                 120                 125             


Ile Lys Asn Ser Asp Ser Phe Asp Lys Phe Glu Phe Cys Glu Pro Ala 
    130                 135                 140                 


Phe Val Val Gly Asn Cys Leu Gln Ile Ala Ser Asp Ser His Gln Tyr 
145                 150                 155                 160 


Asp Arg Ile Tyr Cys Gly Ala Gly Val Gln Lys Asp His Glu Asn Tyr 
                165                 170                 175     


Met Lys Ile Leu Leu Lys Val Gly Gly Ile Leu Val Met Pro Ile Glu 
            180                 185                 190         


Asp Gln Leu Thr Gln Ile Met Arg Thr Gly Gln Asn Thr Trp Glu Ser 
        195                 200                 205             


Lys Asn Ile Leu Ala Val Ser Phe Ala Pro Leu Val Gln Pro Ser Lys 
    210                 215                 220                 


Asn Asp Asn Gly Lys Pro Asp Ser Val Gly Leu Pro Pro Cys Ala Val 
225                 230                 235                 240 


Arg Asn Leu Gln Asp Leu Ala Arg Ile Tyr Ile Arg Arg Thr Leu Arg 
                245                 250                 255     


Asn Phe Ile Asn Asp Glu Met Gln Ala Lys Gly Ile Pro Gln Arg Ala 
            260                 265                 270         


Pro Pro Lys Arg Lys Arg Lys Arg Val Lys Gln Arg Ile Asn Thr Tyr 
        275                 280                 285             


Val Phe Val Gly Asn Gln Leu Ile Pro Gln Pro Leu Asp Ser Glu Glu 
    290                 295                 300                 


Asp Glu Lys Met Glu Glu Asp Asn Lys Glu Glu Glu Glu Lys Asp His 
305                 310                 315                 320 


Asn Glu Ala Met Lys Pro Glu Glu Pro Pro Gln Asn Leu Leu Arg Glu 
                325                 330                 335     


Lys Ile Met Lys Leu Pro Leu Pro Glu Ser Leu Lys Ala Tyr Leu Thr 
            340                 345                 350         


Tyr Phe Arg Asp Lys 
        355         


<210> 8544
<211> 160
<212> PRT
<213> Homo sapiens

<400> 8544
Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30          


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45              


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60                  


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80  


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95      


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110         


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125             


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140                 


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160 


<210> 8545
<211> 113
<212> PRT
<213> Homo sapiens

<400> 8545
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys 
    


<210> 8546
<211> 102
<212> PRT
<213> Homo sapiens

<400> 8546
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr Thr 
        35                  40                  45              


Ser Asp Asp Thr Pro Cys Gln Glu Gln Pro Lys Glu Val Leu Lys Ala 
    50                  55                  60                  


Pro Ser Thr Ser Gly Leu Gln Gln Val Ala Phe Gln Pro Gly Gln Lys 
65                  70                  75                  80  


Val Tyr Val Trp Tyr Gly Gly Gln Glu Cys Thr Gly Leu Val Glu Gln 
                85                  90                  95      


His Ser Trp Met Glu Gly 
            100         


<210> 8547
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8547
Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30          


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45              


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60                  


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80  


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95      


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110         


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125             


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140                 


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160 


Glu Glu Lys 
            


<210> 8548
<211> 146
<212> PRT
<213> Homo sapiens

<400> 8548
Met Cys Pro Gly Asn Trp Leu Trp Ala Ser Met Thr Phe Met Ala Arg 
1               5                   10                  15      


Phe Ser Arg Ser Ser Ser Arg Ser Pro Val Arg Thr Arg Gly Thr Leu 
            20                  25                  30          


Glu Glu Met Pro Thr Val Gln His Pro Phe Leu Asn Val Phe Glu Leu 
        35                  40                  45              


Glu Arg Leu Leu Tyr Thr Gly Lys Thr Ala Cys Asn His Ala Asp Glu 
    50                  55                  60                  


Val Trp Pro Gly Leu Tyr Leu Gly Asp Gln Asp Met Ala Asn Asn Arg 
65                  70                  75                  80  


Arg Glu Leu Arg Arg Leu Gly Ile Thr His Val Leu Asn Ala Ser His 
                85                  90                  95      


Ser Arg Trp Arg Gly Thr Pro Glu Ala Tyr Glu Gly Leu Gly Ile Arg 
            100                 105                 110         


Tyr Leu Gly Val Glu Ala His Asp Ser Pro Ala Phe Asp Met Ser Ile 
        115                 120                 125             


His Phe Gln Thr Ala Ala Asp Phe Ile His Arg Ala Leu Ser Gln Pro 
    130                 135                 140                 


Gly Gly 
145     


<210> 8549
<211> 513
<212> PRT
<213> Homo sapiens

<400> 8549
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr Thr 
        35                  40                  45              


Ser Asp Asp Thr Pro Cys Gln Glu Gln Pro Lys Glu Val Leu Lys Ala 
    50                  55                  60                  


Pro Ser Thr Ser Gly Leu Gln Gln Val Ala Phe Gln Pro Gly Gln Lys 
65                  70                  75                  80  


Val Tyr Val Trp Tyr Gly Gly Gln Glu Cys Thr Gly Leu Val Glu Gln 
                85                  90                  95      


His Ser Trp Met Glu Gly Gln Val Thr Val Trp Leu Leu Glu Gln Lys 
            100                 105                 110         


Leu Gln Val Cys Cys Arg Val Glu Glu Val Trp Leu Ala Glu Leu Gln 
        115                 120                 125             


Gly Pro Cys Pro Gln Ala Pro Pro Leu Glu Pro Gly Ala Gln Ala Leu 
    130                 135                 140                 


Ala Tyr Arg Pro Val Ser Arg Asn Ile Asp Val Pro Lys Arg Lys Ser 
145                 150                 155                 160 


Asp Ala Val Glu Met Asp Glu Met Met Ala Ala Met Val Leu Thr Ser 
                165                 170                 175     


Leu Ser Cys Ser Pro Val Val Gln Ser Pro Pro Gly Thr Glu Ala Asn 
            180                 185                 190         


Phe Ser Ala Ser Arg Ala Ala Cys Asp Pro Trp Lys Glu Ser Gly Asp 
        195                 200                 205             


Ile Ser Asp Ser Gly Ser Ser Thr Thr Ser Gly His Trp Ser Gly Ser 
    210                 215                 220                 


Ser Gly Val Ser Thr Pro Ser Pro Pro His Pro Gln Ala Ser Pro Lys 
225                 230                 235                 240 


Tyr Leu Gly Asp Ala Phe Gly Ser Pro Gln Thr Asp His Gly Phe Glu 
                245                 250                 255     


Thr Asp Pro Asp Pro Phe Leu Leu Asp Glu Pro Ala Pro Arg Lys Arg 
            260                 265                 270         


Lys Asn Ser Val Lys Val Met Tyr Lys Cys Leu Trp Pro Asn Cys Gly 
        275                 280                 285             


Lys Val Leu Arg Ser Ile Val Gly Ile Lys Arg His Val Lys Ala Leu 
    290                 295                 300                 


His Leu Gly Asp Thr Val Asp Ser Asp Gln Phe Lys Arg Glu Glu Asp 
305                 310                 315                 320 


Phe Tyr Tyr Thr Glu Val Gln Leu Lys Glu Glu Ser Ala Ala Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Gly Thr Pro Val Pro Gly Thr Pro Thr Ser Glu 
            340                 345                 350         


Pro Ala Pro Thr Pro Ser Met Thr Gly Leu Pro Leu Ser Ala Leu Pro 
        355                 360                 365             


Pro Pro Leu His Lys Ala Gln Ser Ser Gly Pro Glu His Pro Gly Pro 
    370                 375                 380                 


Glu Ser Ser Leu Pro Ser Gly Ala Leu Ser Lys Ser Ala Pro Gly Ser 
385                 390                 395                 400 


Phe Trp His Ile Gln Ala Asp His Ala Tyr Gln Ala Leu Pro Ser Phe 
                405                 410                 415     


Gln Ile Pro Val Ser Pro His Ile Tyr Thr Ser Val Ser Trp Ala Ala 
            420                 425                 430         


Ala Pro Ser Ala Ala Cys Ser Leu Ser Pro Val Arg Ser Arg Ser Leu 
        435                 440                 445             


Ser Phe Ser Glu Pro Gln Gln Pro Ala Pro Ala Met Lys Ser His Leu 
    450                 455                 460                 


Ile Val Thr Ser Pro Pro Arg Ala Gln Ser Gly Ala Arg Lys Ala Arg 
465                 470                 475                 480 


Gly Glu Ala Lys Lys Cys Arg Lys Val Tyr Gly Ile Glu His Arg Asp 
                485                 490                 495     


Gln Trp Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg Phe Leu 
            500                 505                 510         


Asp 
    


<210> 8550
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8550
Met Ala Val Ser Thr Gly Val Lys Val Pro Arg Asn Phe Arg Leu Leu 
1               5                   10                  15      


Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr Val Ser 
            20                  25                  30          


Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp Thr Gly 
        35                  40                  45              


Met Ile Ile Gly Pro Pro Arg Thr Asn Tyr Glu Asn Arg Ile Tyr Ser 
    50                  55                  60                  


Leu Lys Val Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro Ser Val 
65                  70                  75                  80  


Arg Phe Val Thr Lys Ile Asn Met Asn Gly Ile Asn Asn Ser Ser Gly 
                85                  90                  95      


Met Val Asp Ala Arg Ser Ile Pro Val Leu Ala Lys Trp Gln Asn Ser 
            100                 105                 110         


Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met Met Ser 
        115                 120                 125             


Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Thr Tyr Asn 
    130                 135                 140                 


Asn 
145 


<210> 8551
<211> 513
<212> PRT
<213> Homo sapiens

<400> 8551
Met Ala Ser Val Leu Ser Arg Arg Leu Gly Lys Arg Ser Leu Leu Gly 
1               5                   10                  15      


Ala Arg Val Leu Gly Pro Ser Ala Ser Glu Gly Pro Ser Ala Ala Pro 
            20                  25                  30          


Pro Ser Glu Pro Leu Leu Glu Gly Ala Ala Pro Gln Pro Phe Thr Thr 
        35                  40                  45              


Ser Asp Asp Thr Pro Cys Gln Glu Gln Pro Lys Glu Val Leu Lys Ala 
    50                  55                  60                  


Pro Ser Thr Ser Gly Leu Gln Gln Val Ala Phe Gln Pro Gly Gln Lys 
65                  70                  75                  80  


Val Tyr Val Trp Tyr Gly Gly Gln Glu Cys Thr Gly Leu Val Glu Gln 
                85                  90                  95      


His Ser Trp Met Glu Gly Gln Val Thr Val Trp Leu Leu Glu Gln Lys 
            100                 105                 110         


Leu Gln Val Cys Cys Arg Val Glu Glu Val Trp Leu Ala Glu Leu Gln 
        115                 120                 125             


Gly Pro Cys Pro Gln Ala Pro Pro Leu Glu Pro Gly Ala Gln Ala Leu 
    130                 135                 140                 


Ala Tyr Arg Pro Val Ser Arg Asn Ile Asp Val Pro Lys Arg Lys Ser 
145                 150                 155                 160 


Asp Ala Val Glu Met Asp Glu Met Met Ala Ala Met Val Leu Thr Ser 
                165                 170                 175     


Leu Ser Cys Ser Pro Val Val Gln Ser Pro Pro Gly Thr Glu Ala Asn 
            180                 185                 190         


Phe Ser Ala Ser Arg Ala Ala Cys Asp Pro Trp Lys Glu Ser Gly Asp 
        195                 200                 205             


Ile Ser Asp Ser Gly Ser Ser Thr Thr Ser Gly His Trp Ser Gly Ser 
    210                 215                 220                 


Ser Gly Val Ser Thr Pro Ser Pro Pro His Pro Gln Ala Ser Pro Lys 
225                 230                 235                 240 


Tyr Leu Gly Asp Ala Phe Gly Ser Pro Gln Thr Asp His Gly Phe Glu 
                245                 250                 255     


Thr Asp Pro Asp Pro Phe Leu Leu Asp Glu Pro Ala Pro Arg Lys Arg 
            260                 265                 270         


Lys Asn Ser Val Lys Val Met Tyr Lys Cys Leu Trp Pro Asn Cys Gly 
        275                 280                 285             


Lys Val Leu Arg Ser Ile Val Gly Ile Lys Arg His Val Lys Ala Leu 
    290                 295                 300                 


His Leu Gly Asp Thr Val Asp Ser Asp Gln Phe Lys Arg Glu Glu Asp 
305                 310                 315                 320 


Phe Tyr Tyr Thr Glu Val Gln Leu Lys Glu Glu Ser Ala Ala Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Gly Thr Pro Val Pro Gly Thr Pro Thr Ser Glu 
            340                 345                 350         


Pro Ala Pro Thr Pro Ser Met Thr Gly Leu Pro Leu Ser Ala Leu Pro 
        355                 360                 365             


Pro Pro Leu His Lys Ala Gln Ser Ser Gly Pro Glu His Pro Gly Pro 
    370                 375                 380                 


Glu Ser Ser Leu Pro Ser Gly Ala Leu Ser Lys Ser Ala Pro Gly Ser 
385                 390                 395                 400 


Phe Trp His Ile Gln Ala Asp His Ala Tyr Gln Ala Leu Pro Ser Phe 
                405                 410                 415     


Gln Ile Pro Val Ser Pro His Ile Tyr Thr Ser Val Ser Trp Ala Ala 
            420                 425                 430         


Ala Pro Ser Ala Ala Cys Ser Leu Ser Pro Val Arg Ser Arg Ser Leu 
        435                 440                 445             


Ser Phe Ser Glu Pro Gln Gln Pro Ala Pro Ala Met Lys Ser His Leu 
    450                 455                 460                 


Ile Val Thr Ser Pro Pro Arg Ala Gln Ser Gly Ala Arg Lys Ala Arg 
465                 470                 475                 480 


Gly Glu Ala Lys Lys Cys Arg Lys Val Tyr Gly Ile Glu His Arg Asp 
                485                 490                 495     


Gln Trp Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg Phe Leu 
            500                 505                 510         


Asp 
    


<210> 8552
<211> 18
<212> PRT
<213> Homo sapiens

<400> 8552
Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val 
        


<210> 8553
<211> 644
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<400> 8553
Val Ala Ser Glu Gly Ser Val Arg Arg Pro Ser Gly Pro Val Pro Ala 
1               5                   10                  15      


Pro Gln Pro Pro Ala Phe Arg Phe Val Ser Arg Pro Gly Arg Ala Arg 
            20                  25                  30          


Ser Glu Ser Glu Thr Leu Glu Arg Ser Pro Pro Gln Ser Pro Gly Pro 
        35                  40                  45              


Gly Lys Ala Gly Asp Ala Pro Asn Arg Arg Ser Gly His Val Arg Gly 
    50                  55                  60                  


Ala Arg Val Leu Ser Pro Pro Gly Arg Arg Ala Arg Leu Ser Ser Pro 
65                  70                  75                  80  


Gly Pro Ser Arg Ser Ser Glu Ala Arg Glu Glu Leu Arg Arg His Leu 
                85                  90                  95      


Val Gly Leu Ile Glu Arg Ser Arg Val Val Ile Phe Ser Lys Ser Tyr 
            100                 105                 110         


Cys Pro His Ser Thr Arg Val Lys Glu Leu Phe Ser Ser Leu Gly Val 
        115                 120                 125             


Glu Cys Asn Val Leu Glu Leu Asp Gln Val Asp Asp Gly Ala Arg Val 
    130                 135                 140                 


Gln Glu Val Leu Ser Glu Ile Thr Asn Gln Lys Thr Val Pro Asn Ile 
145                 150                 155                 160 


Phe Val Asn Lys Val His Val Gly Gly Cys Asp Gln Thr Phe Gln Ala 
                165                 170                 175     


Tyr Gln Ser Gly Leu Leu Gln Lys Leu Leu Gln Glu Asp Leu Ala Tyr 
            180                 185                 190         


Asp Tyr Asp Leu Ile Ile Ile Gly Gly Gly Ser Gly Gly Leu Ser Cys 
        195                 200                 205             


Ala Lys Glu Ala Ala Ile Leu Gly Lys Lys Val Met Val Leu Asp Phe 
    210                 215                 220                 


Val Val Pro Ser Pro Gln Gly Thr Ser Trp Gly Leu Gly Gly Thr Cys 
225                 230                 235                 240 


Val Asn Val Gly Cys Ile Pro Lys Lys Leu Met His Gln Ala Ala Leu 
                245                 250                 255     


Leu Gly Gln Ala Leu Cys Asp Ser Arg Lys Phe Gly Trp Glu Tyr Asn 
            260                 265                 270         


Gln Gln Val Arg His Asn Trp Glu Thr Met Thr Lys Ala Ile Gln Asn 
        275                 280                 285             


His Ile Ser Ser Leu Asn Trp Gly Tyr Arg Leu Ser Leu Arg Glu Lys 
    290                 295                 300                 


Ala Val Ala Tyr Val Asn Ser Tyr Gly Glu Phe Val Glu His His Lys 
305                 310                 315                 320 


Ile Lys Ala Thr Asn Lys Lys Gly Gln Glu Thr Tyr Tyr Thr Ala Ala 
                325                 330                 335     


Gln Phe Val Ile Ala Thr Gly Glu Arg Pro Arg Tyr Leu Gly Ile Gln 
            340                 345                 350         


Gly Asp Lys Glu Tyr Cys Ile Thr Ser Asp Asp Leu Phe Ser Leu Pro 
        355                 360                 365             


Tyr Cys Pro Gly Lys Thr Leu Val Val Gly Ala Ser Tyr Val Ala Leu 
    370                 375                 380                 


Glu Cys Ala Gly Phe Leu Ala Gly Phe Gly Leu Asp Val Thr Val Met 
385                 390                 395                 400 


Val Arg Ser Ile Leu Leu Arg Gly Phe Asp Gln Glu Met Ala Glu Lys 
                405                 410                 415     


Val Gly Ser Tyr Met Glu Gln His Gly Val Lys Phe Leu Arg Lys Phe 
            420                 425                 430         


Ile Pro Val Met Val Gln Gln Leu Glu Lys Gly Ser Pro Gly Lys Leu 
        435                 440                 445             


Lys Val Leu Ala Lys Ser Thr Glu Gly Thr Glu Thr Ile Glu Gly Val 
    450                 455                 460                 


Tyr Asn Thr Val Leu Leu Ala Ile Gly Arg Asp Ser Cys Thr Arg Lys 
465                 470                 475                 480 


Ile Gly Leu Glu Lys Ile Gly Val Lys Ile Asn Glu Lys Ser Gly Lys 
                485                 490                 495     


Ile Pro Val Asn Asp Val Glu Gln Thr Asn Val Pro Tyr Val Tyr Ala 
            500                 505                 510         


Val Gly Asp Ile Leu Glu Asp Lys Pro Glu Leu Thr Pro Val Ala Ile 
        515                 520                 525             


Gln Ser Gly Lys Leu Leu Ala Gln Arg Leu Phe Gly Ala Ser Leu Glu 
    530                 535                 540                 


Lys Ile Tyr His Thr Leu Phe Trp Pro Leu Glu Trp Thr Val Ala Gly 
545                 550                 555                 560 


Arg Glu Asn Asn Thr Cys Tyr Ala Lys Ile Ile Cys Asn Lys Phe Asp 
                565                 570                 575     


His Asp Arg Val Ile Gly Phe His Ile Leu Gly Pro Asn Ala Gly Glu 
            580                 585                 590         


Val Thr Gln Gly Phe Ala Ala Ala Met Lys Cys Gly Leu Thr Lys Gln 
        595                 600                 605             


Leu Leu Asp Asp Thr Ile Gly Ile His Pro Thr Cys Gly Glu Val Phe 
    610                 615                 620                 


Thr Thr Leu Glu Ile Thr Lys Ser Ser Gly Leu Asp Ile Thr Gln Lys 
625                 630                 635                 640 


Gly Cys Cys Gly 
                


<210> 8554
<211> 445
<212> PRT
<213> Homo sapiens

<400> 8554
Met Asn Lys Gly Ile Ser Ser Ile Pro Ile Asn Leu Arg Val Tyr Ser 
1               5                   10                  15      


Pro His Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys 
            20                  25                  30          


Val Pro Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Glu 
        35                  40                  45              


Met Ile Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val 
    50                  55                  60                  


Thr Pro Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Lys Glu Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys 
                85                  90                  95      


Leu Asp Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn 
            100                 105                 110         


Lys Leu Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser 
        115                 120                 125             


Gln Lys Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala 
    130                 135                 140                 


Glu Arg Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp 
145                 150                 155                 160 


Arg Met Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr 
                165                 170                 175     


Asn His Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly 
            180                 185                 190         


Gln Leu Leu Ser Ile Glu His Glu Val Glu Ala Tyr Lys Asn Phe Lys 
        195                 200                 205             


Pro Glu Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln 
    210                 215                 220                 


Gln Phe Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln 
225                 230                 235                 240 


Val Asp Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe 
                245                 250                 255     


His Glu Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys 
            260                 265                 270         


Glu Leu Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile 
        275                 280                 285             


Arg Thr Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Ile Val Lys 
    290                 295                 300                 


Lys Gln Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu 
305                 310                 315                 320 


Val Ile Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Lys Leu 
                325                 330                 335     


Ala Asn Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn 
            340                 345                 350         


His Ile Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu 
        355                 360                 365             


Ile Asp Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile 
    370                 375                 380                 


Gly Phe Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Thr 
385                 390                 395                 400 


Thr Val Gly Asn Gln Val Ile Arg Lys Gly Trp Leu Thr Ile Ser Asn 
                405                 410                 415     


Ile Gly Ile Met Lys Gly Gly Ser Lys Gly Tyr Trp Phe Val Leu Thr 
            420                 425                 430         


Ala Glu Ser Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys 
        435                 440                 445 


<210> 8555
<211> 519
<212> PRT
<213> Homo sapiens

<400> 8555
Met Leu Gln Leu Met Asp Ser Gly Ile Thr Ile Cys Leu Arg Asn Gly 
1               5                   10                  15      


Ala Ala Ser Val Phe Lys Lys Lys Glu Trp Ser Thr Gln Gly Glu Glu 
            20                  25                  30          


Asn Lys Gln Asp Ser Lys Leu Lys Lys Leu Ser Glu Asp Ser Leu Thr 
        35                  40                  45              


Lys Gln Pro Glu Glu Val Phe Asp Val Leu Glu Lys Leu Gly Glu Gly 
    50                  55                  60                  


Ser Tyr Gly Ser Val Phe Lys Ala Ile His Lys Glu Ser Gly Gln Val 
65                  70                  75                  80  


Val Ala Ile Lys Gln Val Pro Val Glu Ser Asp Leu Gln Glu Ile Ile 
                85                  90                  95      


Lys Glu Ile Ser Ile Met Gln Gln Cys Asp Ser Pro Tyr Val Val Lys 
            100                 105                 110         


Tyr Tyr Gly Ser Tyr Phe Lys Asn Thr Asp Leu Trp Ile Val Met Glu 
        115                 120                 125             


Tyr Cys Gly Ala Gly Ser Val Ser Asp Ile Ile Arg Leu Arg Asn Lys 
    130                 135                 140                 


Thr Leu Ile Glu Asp Glu Ile Ala Thr Ile Leu Lys Ser Thr Leu Lys 
145                 150                 155                 160 


Gly Leu Glu Tyr Leu His Phe Met Arg Lys Ile His Arg Asp Ile Lys 
                165                 170                 175     


Ala Gly Asn Ile Leu Leu Asn Thr Glu Gly His Ala Lys Leu Ala Asp 
            180                 185                 190         


Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Met Ala Lys Arg Asn Thr 
        195                 200                 205             


Val Ile Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Gln Glu Ile 
    210                 215                 220                 


Gly Tyr Asn Cys Val Ala Asp Ile Trp Ser Leu Gly Ile Thr Ser Ile 
225                 230                 235                 240 


Glu Met Ala Glu Gly Lys Pro Pro Tyr Ala Asp Ile His Pro Met Arg 
                245                 250                 255     


Ala Ile Phe Met Ile Pro Thr Asn Pro Pro Pro Thr Phe Arg Lys Pro 
            260                 265                 270         


Glu Leu Trp Ser Asp Asp Phe Thr Asp Phe Val Lys Lys Cys Leu Val 
        275                 280                 285             


Lys Asn Pro Glu Gln Arg Ala Thr Ala Thr Gln Leu Leu Gln His Pro 
    290                 295                 300                 


Phe Ile Lys Asn Ala Lys Pro Val Ser Ile Leu Arg Asp Leu Ile Thr 
305                 310                 315                 320 


Glu Ala Met Glu Ile Lys Ala Lys Arg His Glu Glu Gln Gln Arg Glu 
                325                 330                 335     


Leu Glu Glu Glu Glu Glu Asn Ser Asp Glu Asp Glu Leu Asp Ser His 
            340                 345                 350         


Thr Met Val Lys Thr Ser Val Glu Ser Val Gly Thr Met Arg Ala Thr 
        355                 360                 365             


Ser Thr Met Ser Glu Gly Ala Gln Thr Met Ile Glu His Asn Ser Thr 
    370                 375                 380                 


Met Leu Glu Ser Asp Leu Gly Thr Met Val Ile Asn Ser Glu Asp Glu 
385                 390                 395                 400 


Glu Glu Glu Asp Gly Thr Met Lys Arg Asn Ala Thr Ser Pro Gln Val 
                405                 410                 415     


Gln Arg Pro Ser Phe Met Asp Tyr Phe Asp Lys Gln Asp Phe Lys Asn 
            420                 425                 430         


Lys Ser His Glu Asn Cys Asn Gln Asn Met His Glu Pro Phe Pro Met 
        435                 440                 445             


Ser Lys Asn Val Phe Pro Asp Asn Trp Lys Val Pro Gln Asp Gly Asp 
    450                 455                 460                 


Phe Asp Phe Leu Lys Asn Leu Ser Leu Glu Glu Leu Gln Met Arg Leu 
465                 470                 475                 480 


Lys Ala Leu Asp Pro Met Met Glu Arg Glu Ile Glu Glu Leu Arg Gln 
                485                 490                 495     


Arg Tyr Thr Ala Lys Arg Gln Pro Ile Leu Asp Ala Met Asp Ala Lys 
            500                 505                 510         


Lys Arg Arg Gln Gln Asn Phe 
        515                 


<210> 8556
<211> 463
<212> PRT
<213> Homo sapiens

<400> 8556
Met Lys Ile Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr 
1               5                   10                  15      


His Lys Pro Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu 
            20                  25                  30          


Pro Ser Gln Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys 
        35                  40                  45              


Ile Leu His Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr 
    50                  55                  60                  


Leu Gln Glu Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Asn Leu Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala 
                85                  90                  95      


Leu Glu Asn Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile 
            100                 105                 110         


Lys Gln Lys Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg 
        115                 120                 125             


Cys Thr Leu Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu 
    130                 135                 140                 


Asn Val Glu Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu 
145                 150                 155                 160 


Gln Arg Glu Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu 
                165                 170                 175     


Lys Leu Asp Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln 
            180                 185                 190         


Lys Thr Ala Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu 
        195                 200                 205             


Glu Glu His Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Leu Gln 
    210                 215                 220                 


Thr Gly Leu Glu Ile Ser Lys Ile Ile Met Ser Ser Val Ser Asn Leu 
225                 230                 235                 240 


Lys His Ser Lys Glu Lys Lys Lys Ser Ser Lys Lys Thr Lys Cys Ile 
                245                 250                 255     


Lys Arg Arg Pro Pro Trp Gln Ile Cys Ser Lys Phe Gly Ala Leu Pro 
            260                 265                 270         


Phe Val Ala Glu Lys Met Arg Gln His Arg Asp Pro His Ile Leu Gln 
        275                 280                 285             


Lys Pro Phe Asn Val Thr Glu Thr Arg Cys Leu Pro Lys Pro Ser Arg 
    290                 295                 300                 


Thr Thr Ser Trp Cys Lys Ala Ile Pro Pro Asp Ser Glu Lys Ser Ile 
305                 310                 315                 320 


Ser Ile Cys Asp Asn Leu Ser Glu Leu Leu Met Ala Met Gln Asp Glu 
                325                 330                 335     


Leu Asp Gln Met Ser Met Glu His Gln Glu Leu Leu Lys Gln Met Lys 
            340                 345                 350         


Glu Thr Glu Ser His Ser Val Cys Asp Asp Ile Glu Cys Glu Leu Glu 
        355                 360                 365             


Cys Leu Leu Lys Lys Met Glu Ile Lys Gly Glu Gln Ile Ser Lys Leu 
    370                 375                 380                 


Lys Lys His Gln Asp Ser Val Cys Lys Leu Gln Gln Lys Val Gln Asn 
385                 390                 395                 400 


Ser Lys Met Ser Glu Ala Ser Gly Ile Gln Gln Glu Asp Ser Tyr Pro 
                405                 410                 415     


Lys Gly Ser Lys Asn Ile Lys Asn Ser Pro Arg Lys Cys Leu Thr Asp 
            420                 425                 430         


Thr Asn Leu Phe Gln Lys Asn Ser Ser Phe His Pro Ile Arg Val His 
        435                 440                 445             


Asn Leu Gln Met Lys Leu Arg Arg Asp Asp Ile Met Trp Glu Gln 
    450                 455                 460             


<210> 8557
<211> 349
<212> PRT
<213> Homo sapiens

<400> 8557
Met Glu Asp Pro Gln Ser Lys Glu Pro Ala Gly Glu Ala Val Ala Leu 
1               5                   10                  15      


Ala Leu Leu Glu Ser Pro Arg Pro Glu Gly Gly Glu Glu Pro Pro Arg 
            20                  25                  30          


Pro Ser Pro Glu Glu Thr Gln Gln Cys Lys Phe Asp Gly Gln Glu Thr 
        35                  40                  45              


Lys Gly Ser Lys Phe Ile Thr Ser Ser Ala Ser Asp Phe Ser Asp Pro 
    50                  55                  60                  


Val Tyr Lys Glu Ile Ala Ile Thr Asn Gly Cys Ile Asn Arg Met Ser 
65                  70                  75                  80  


Lys Glu Glu Leu Arg Ala Lys Leu Ser Glu Phe Lys Leu Glu Thr Arg 
                85                  90                  95      


Gly Val Lys Asp Val Leu Lys Lys Arg Leu Lys Asn Tyr Tyr Lys Lys 
            100                 105                 110         


Gln Lys Leu Met Leu Lys Glu Ser Asn Phe Ala Asp Ser Tyr Tyr Asp 
        115                 120                 125             


Tyr Ile Cys Ile Ile Asp Phe Glu Ala Thr Cys Glu Glu Gly Asn Pro 
    130                 135                 140                 


Pro Glu Phe Val His Glu Ile Ile Glu Phe Pro Val Val Leu Leu Asn 
145                 150                 155                 160 


Thr His Thr Leu Glu Ile Glu Asp Thr Phe Gln Gln Tyr Val Arg Pro 
                165                 170                 175     


Glu Ile Asn Thr Gln Leu Ser Asp Phe Cys Ile Ser Leu Thr Gly Ile 
            180                 185                 190         


Thr Gln Asp Gln Val Asp Arg Ala Asp Thr Phe Pro Gln Val Leu Lys 
        195                 200                 205             


Lys Val Ile Asp Trp Met Lys Leu Lys Glu Leu Gly Thr Lys Tyr Lys 
    210                 215                 220                 


Tyr Ser Leu Leu Thr Asp Gly Ser Trp Asp Met Ser Lys Phe Leu Asn 
225                 230                 235                 240 


Ile Gln Cys Gln Leu Ser Arg Leu Lys Tyr Pro Pro Phe Ala Lys Lys 
                245                 250                 255     


Trp Ile Asn Ile Arg Lys Ser Tyr Gly Asn Phe Tyr Lys Val Pro Arg 
            260                 265                 270         


Ser Gln Thr Lys Leu Thr Ile Met Leu Glu Lys Leu Gly Met Asp Tyr 
        275                 280                 285             


Asp Gly Arg Pro His Cys Gly Leu Asp Asp Ser Lys Asn Ile Ala Arg 
    290                 295                 300                 


Ile Ala Val Arg Met Leu Gln Asp Gly Cys Glu Leu Arg Ile Asn Glu 
305                 310                 315                 320 


Lys Met His Ala Gly Gln Leu Met Ser Val Ser Ser Ser Leu Pro Ile 
                325                 330                 335     


Glu Gly Thr Pro Pro Pro Gln Met Pro His Phe Arg Lys 
            340                 345                 


<210> 8558
<211> 211
<212> PRT
<213> Homo sapiens

<400> 8558
Met Cys Pro Gly Asn Trp Leu Trp Ala Ser Met Thr Phe Met Ala Arg 
1               5                   10                  15      


Phe Ser Arg Ser Ser Ser Arg Ser Pro Val Arg Thr Arg Gly Thr Leu 
            20                  25                  30          


Glu Glu Met Pro Thr Val Gln His Pro Phe Leu Asn Val Phe Glu Leu 
        35                  40                  45              


Glu Arg Leu Leu Tyr Thr Gly Lys Thr Ala Cys Asn His Ala Asp Glu 
    50                  55                  60                  


Val Trp Pro Gly Leu Tyr Leu Gly Asp Gln Asp Met Ala Asn Asn Arg 
65                  70                  75                  80  


Arg Glu Leu Arg Arg Leu Gly Ile Thr His Val Leu Asn Ala Ser His 
                85                  90                  95      


Ser Arg Trp Arg Gly Thr Pro Glu Ala Tyr Glu Gly Leu Gly Ile Arg 
            100                 105                 110         


Tyr Leu Gly Val Glu Ala His Asp Ser Pro Ala Phe Asp Met Ser Ile 
        115                 120                 125             


His Phe Gln Thr Ala Ala Asp Phe Ile His Arg Ala Leu Ser Gln Pro 
    130                 135                 140                 


Gly Gly Lys Ile Leu Val His Cys Ala Val Gly Val Ser Arg Ser Ala 
145                 150                 155                 160 


Thr Leu Val Leu Ala Tyr Leu Met Leu Tyr His His Leu Thr Leu Val 
                165                 170                 175     


Glu Ala Ile Lys Lys Val Lys Asp His Arg Gly Ile Ile Pro Asn Arg 
            180                 185                 190         


Gly Phe Leu Arg Gln Leu Leu Ala Leu Asp Arg Arg Leu Arg Gln Gly 
        195                 200                 205             


Leu Glu Ala 
    210     


<210> 8559
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8559
Met Ile Pro Ile Trp Lys Gln Gln Ala Arg Pro Gly Asp Gly Pro Val 
1               5                   10                  15      


Ile Trp Asp Tyr His Val Val Leu Leu His Val Ser Ser Gly Gly Gln 
            20                  25                  30          


Asn Phe Ile Tyr Asp Leu Asp Thr Val Leu Pro Phe Pro Cys Leu Phe 
        35                  40                  45              


Asp Thr Tyr Val Glu Asp Ala Phe Lys Ser Asp Asp Asp Ile His Pro 
    50                  55                  60                  


Gln Phe Arg Arg Lys Phe Arg Val Ile Arg Ala Asp Ser Tyr Leu Lys 
65                  70                  75                  80  


Asn Phe Ala Ser Asp Arg Ser His Met Lys Asp Ser Ser Gly Asn Trp 
                85                  90                  95      


Arg Glu Pro Pro Pro Pro Tyr Pro Cys Ile Glu Thr Gly Asp Ser Lys 
            100                 105                 110         


Met Asn Leu Asn Asp Phe Ile Ser Met Asp Pro Lys Val Gly Trp Gly 
        115                 120                 125             


Ala Val Tyr Thr Leu Ser Glu Phe Thr His Arg Phe Gly Ser Lys Asn 
    130                 135                 140                 


Cys 
145 


<210> 8560
<211> 85
<212> PRT
<213> Homo sapiens

<400> 8560
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser 
                85  


<210> 8561
<211> 195
<212> PRT
<213> Homo sapiens

<400> 8561
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg Cys Thr Leu 
        115                 120                 125             


Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu Asn Val Glu 
    130                 135                 140                 


Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu Gln Arg Glu 
145                 150                 155                 160 


Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu Lys Leu Asp 
                165                 170                 175     


Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln Lys Thr Ala 
            180                 185                 190         


Glu Asp Lys 
        195 


<210> 8562
<211> 423
<212> PRT
<213> Homo sapiens

<400> 8562
Met Glu Asp Lys Arg Ser Leu Ser Met Ala Arg Cys Glu Glu Arg Asn 
1               5                   10                  15      


Ser Arg Gly Gln Asp His Gly Leu Glu Arg Val Pro Phe Pro Pro Gln 
            20                  25                  30          


Leu Gln Ser Glu Thr Tyr Leu His Pro Ala Asp Pro Ser Pro Ala Trp 
        35                  40                  45              


Asp Asp Pro Gly Ser Thr Gly Ser Pro Asn Leu Arg Leu Leu Thr Glu 
    50                  55                  60                  


Glu Ile Ala Phe Gln Pro Leu Ala Glu Glu Ala Ser Phe Arg Arg Pro 
65                  70                  75                  80  


His Pro Asp Gly Asp Val Pro Pro Gln Gly Glu Asp Asn Leu Leu Ser 
                85                  90                  95      


Leu Pro Phe Pro Gln Lys Leu Trp Arg Leu Val Ser Ser Asn Gln Phe 
            100                 105                 110         


Ser Ser Ile Trp Trp Asp Asp Ser Gly Ala Cys Arg Val Ile Asn Gln 
        115                 120                 125             


Lys Leu Phe Glu Lys Glu Ile Leu Lys Arg Asp Val Ala His Lys Val 
    130                 135                 140                 


Phe Ala Thr Thr Ser Ile Lys Ser Phe Phe Arg Gln Leu Asn Leu Tyr 
145                 150                 155                 160 


Gly Phe Arg Lys Arg Arg Gln Cys Thr Phe Arg Thr Phe Thr Arg Ile 
                165                 170                 175     


Phe Ser Ala Lys Arg Leu Val Ser Ile Leu Asn Lys Leu Glu Phe Tyr 
            180                 185                 190         


Cys His Pro Tyr Phe Gln Arg Asp Ser Pro His Leu Leu Val Arg Met 
        195                 200                 205             


Lys Arg Arg Val Gly Val Lys Ser Ala Pro Arg His Gln Glu Glu Asp 
    210                 215                 220                 


Lys Pro Glu Ala Ala Gly Ser Cys Leu Ala Pro Ala Asp Thr Glu Gln 
225                 230                 235                 240 


Gln Asp His Thr Ser Pro Asn Glu Asn Asp Gln Val Thr Pro Gln His 
                245                 250                 255     


Arg Glu Pro Ala Gly Pro Asn Thr Gln Ile Arg Ser Gly Ser Ala Pro 
            260                 265                 270         


Pro Ala Thr Pro Val Met Val Pro Asp Ser Ala Val Ala Ser Asp Asn 
        275                 280                 285             


Ser Pro Val Thr Gln Pro Ala Gly Glu Trp Ser Glu Gly Ser Gln Ala 
    290                 295                 300                 


His Val Thr Pro Val Ala Ala Val Pro Gly Pro Ala Ala Leu Pro Phe 
305                 310                 315                 320 


Leu Tyr Val Pro Gly Ser Pro Thr Gln Met Asn Ser Tyr Gly Pro Val 
                325                 330                 335     


Val Ala Leu Pro Thr Ala Ser Arg Ser Thr Leu Ala Met Asp Thr Thr 
            340                 345                 350         


Gly Leu Pro Ala Pro Gly Met Leu Pro Phe Cys His Leu Trp Val Pro 
        355                 360                 365             


Val Thr Leu Val Ala Ala Gly Ala Ala Gln Pro Ala Ala Ser Met Val 
    370                 375                 380                 


Met Phe Pro His Leu Pro Ala Leu His His His Cys Pro His Ser His 
385                 390                 395                 400 


Arg Thr Ser Gln Tyr Met Pro Ala Ser Asp Gly Pro Gln Ala Tyr Pro 
                405                 410                 415     


Asp Tyr Ala Asp Gln Ser Thr 
            420             


<210> 8563
<211> 698
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<400> 8563
Gly Val Gly Gly Arg Gly Glu Arg Leu Pro Arg Gly Phe Ala Arg Val 
1               5                   10                  15      


Val Arg Val Ala Ser Glu Gly Ser Val Arg Arg Pro Ser Gly Pro Val 
            20                  25                  30          


Pro Ala Pro Gln Pro Pro Ala Phe Arg Phe Val Ser Arg Pro Gly Arg 
        35                  40                  45              


Ala Arg Ser Glu Ser Glu Thr Leu Glu Arg Ser Pro Pro Gln Ser Pro 
    50                  55                  60                  


Gly Pro Gly Lys Ala Gly Asp Ala Pro Asn Arg Arg Ser Gly His Val 
65                  70                  75                  80  


Arg Gly Ala Arg Val Leu Ser Pro Pro Gly Arg Arg Ala Arg Leu Ser 
                85                  90                  95      


Ser Pro Gly Pro Ser Arg Ser Ser Glu Ala Arg Glu Glu Leu Arg Arg 
            100                 105                 110         


His Leu Val Gly Leu Ile Glu Arg Ser Arg Val Val Ile Phe Ser Lys 
        115                 120                 125             


Ser Tyr Cys Pro His Ser Thr Arg Val Lys Glu Leu Phe Ser Ser Leu 
    130                 135                 140                 


Gly Val Glu Cys Asn Val Leu Glu Leu Asp Gln Val Asp Asp Gly Ala 
145                 150                 155                 160 


Arg Val Gln Glu Val Leu Ser Glu Ile Thr Asn Gln Lys Thr Val Pro 
                165                 170                 175     


Asn Ile Phe Val Asn Lys Val His Val Gly Gly Cys Asp Gln Thr Phe 
            180                 185                 190         


Gln Ala Tyr Gln Ser Gly Leu Leu Gln Lys Leu Leu Gln Glu Asp Leu 
        195                 200                 205             


Ala Tyr Asp Tyr Asp Leu Ile Ile Ile Gly Gly Gly Ser Gly Gly Leu 
    210                 215                 220                 


Ser Cys Ala Lys Glu Ala Ala Ile Leu Gly Lys Lys Val Met Val Leu 
225                 230                 235                 240 


Asp Phe Val Val Pro Ser Pro Gln Gly Thr Ser Trp Gly Leu Gly Gly 
                245                 250                 255     


Thr Cys Val Asn Val Gly Cys Ile Pro Lys Lys Leu Met His Gln Ala 
            260                 265                 270         


Ala Leu Leu Gly Gln Ala Leu Cys Asp Ser Arg Lys Phe Gly Trp Glu 
        275                 280                 285             


Tyr Asn Gln Gln Val Arg His Asn Trp Glu Thr Met Thr Lys Ala Ile 
    290                 295                 300                 


Gln Asn His Ile Ser Ser Leu Asn Trp Gly Tyr Arg Leu Ser Leu Arg 
305                 310                 315                 320 


Glu Lys Ala Val Ala Tyr Val Asn Ser Tyr Gly Glu Phe Val Glu His 
                325                 330                 335     


His Lys Ile Lys Ala Thr Asn Lys Lys Gly Gln Glu Thr Tyr Tyr Thr 
            340                 345                 350         


Ala Ala Gln Phe Val Ile Ala Thr Gly Glu Arg Pro Arg Tyr Leu Gly 
        355                 360                 365             


Ile Gln Gly Asp Lys Glu Tyr Cys Ile Thr Ser Asp Asp Leu Phe Ser 
    370                 375                 380                 


Leu Pro Tyr Cys Pro Gly Lys Thr Leu Val Val Gly Ala Ser Tyr Val 
385                 390                 395                 400 


Ala Leu Glu Cys Ala Gly Phe Leu Ala Gly Phe Gly Leu Asp Val Thr 
                405                 410                 415     


Val Met Val Arg Ser Ile Leu Leu Arg Gly Phe Asp Gln Glu Met Ala 
            420                 425                 430         


Glu Lys Val Gly Ser Tyr Met Glu Gln His Gly Val Lys Phe Leu Arg 
        435                 440                 445             


Lys Phe Ile Pro Val Met Val Gln Gln Leu Glu Lys Gly Ser Pro Gly 
    450                 455                 460                 


Lys Leu Lys Val Leu Ala Lys Ser Thr Glu Gly Thr Glu Thr Ile Glu 
465                 470                 475                 480 


Gly Val Tyr Asn Thr Val Leu Leu Ala Ile Gly Arg Asp Ser Cys Thr 
                485                 490                 495     


Arg Lys Ile Gly Leu Glu Lys Ile Gly Val Lys Ile Asn Glu Lys Ser 
            500                 505                 510         


Gly Lys Ile Pro Val Asn Asp Val Glu Gln Thr Asn Val Pro Tyr Val 
        515                 520                 525             


Tyr Ala Val Gly Asp Ile Leu Glu Asp Lys Pro Glu Leu Thr Pro Val 
    530                 535                 540                 


Ala Ile Gln Ser Gly Lys Leu Leu Ala Gln Arg Leu Phe Gly Ala Ser 
545                 550                 555                 560 


Leu Glu Lys Cys Asp Tyr Ile Asn Val Pro Thr Thr Val Phe Thr Pro 
                565                 570                 575     


Leu Glu Tyr Gly Cys Cys Gly Leu Ser Glu Glu Lys Ala Ile Glu Val 
            580                 585                 590         


Tyr Lys Lys Glu Asn Leu Glu Ile Tyr His Thr Leu Phe Trp Pro Leu 
        595                 600                 605             


Glu Trp Thr Val Ala Gly Arg Glu Asn Asn Thr Cys Tyr Ala Lys Ile 
    610                 615                 620                 


Ile Cys Asn Lys Phe Asp His Asp Arg Val Ile Gly Phe His Ile Leu 
625                 630                 635                 640 


Gly Pro Asn Ala Gly Glu Val Thr Gln Gly Phe Ala Ala Ala Met Lys 
                645                 650                 655     


Cys Gly Leu Thr Lys Gln Leu Leu Asp Asp Thr Ile Gly Ile His Pro 
            660                 665                 670         


Thr Cys Gly Glu Val Phe Thr Thr Leu Glu Ile Thr Lys Ser Ser Gly 
        675                 680                 685             


Leu Asp Ile Thr Gln Lys Gly Cys Cys Gly 
    690                 695             


<210> 8564
<211> 202
<212> PRT
<213> Homo sapiens

<400> 8564
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg Val 
            100                 105                 110         


Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu Gly 
        115                 120                 125             


Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln Glu 
    130                 135                 140                 


Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys Thr 
145                 150                 155                 160 


Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu Glu 
                165                 170                 175     


Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn 
            180                 185                 190         


Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala 
        195                 200         


<210> 8565
<211> 480
<212> PRT
<213> Homo sapiens

<400> 8565
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Met Val Pro Gly Lys Glu Gly Gly 
            260                 265                 270         


Val Pro Leu Ala Pro Asn Gln Pro Val His Gly Thr Gln Ala Asp Gln 
        275                 280                 285             


Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg Thr His Cys Ala Ala 
    290                 295                 300                 


Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val Ser Asn Ser Ser Glu 
305                 310                 315                 320 


Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr Ile Phe Val Arg Lys 
                325                 330                 335     


Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln Val Thr Leu Thr Ser 
            340                 345                 350         


Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys Asn Leu Glu Leu Glu 
        355                 360                 365             


Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser Pro Glu Thr Glu Ser 
    370                 375                 380                 


Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asn Thr His Asp Asp Phe Val Met Ile Asp Phe Lys Pro Ala Phe 
                405                 410                 415     


Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly Thr Phe Tyr Arg Glu 
            420                 425                 430         


Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser Ile Asp Ile Gly Ala 
        435                 440                 445             


Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro Glu Lys Leu Ala Val 
    450                 455                 460                 


His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe Val Glu Thr Leu Gln 
465                 470                 475                 480 


<210> 8566
<211> 102
<212> PRT
<213> Homo sapiens

<400> 8566
Met Leu Ser Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln 
1               5                   10                  15      


Leu Glu Asp Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu 
            20                  25                  30          


Arg His Leu Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn 
        35                  40                  45              


Glu Leu Lys Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr 
    50                  55                  60                  


Thr Ala Tyr Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys 
65                  70                  75                  80  


Ala Thr Ala Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe 
                85                  90                  95      


Gly Asp Met Arg Arg Lys 
            100         


<210> 8567
<211> 105
<212> PRT
<213> Homo sapiens

<400> 8567
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val Gln 
65                  70                  75                  80  


Leu Ser Ser Lys Glu Lys Ile Trp Thr Gln Glu Met Leu Leu Gln Val 
                85                  90                  95      


Asn Asp Gln Ser Leu Arg Leu Leu Asp 
            100                 105 


<210> 8568
<211> 73
<212> PRT
<213> Homo sapiens

<400> 8568
Met Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu 
1               5                   10                  15      


Ile Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp 
            20                  25                  30          


Cys Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys 
        35                  40                  45              


Ser Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His 
    50                  55                  60                  


Ser Gln Glu Thr Lys His Tyr Leu Thr 
65                  70              


<210> 8569
<211> 91
<212> PRT
<213> Homo sapiens

<400> 8569
Met Ala Met Thr Val Val Thr Lys Glu Lys Asn Lys Lys Val Pro Thr 
1               5                   10                  15      


Ile Phe Leu Ser Lys Lys Pro Arg Glu Lys Glu Val Asp Ser Lys Ser 
            20                  25                  30          


Gln Val Ile Glu Gly Ile Ser Arg Leu Ile Cys Ser Ala Lys Gln Gln 
        35                  40                  45              


Gln Thr Met Leu Arg Val Ser Ile Asp Gly Val Glu Trp Ser Asp Ile 
    50                  55                  60                  


Lys Phe Phe Gln Leu Ala Ala Gln Trp Pro Thr His Val Lys His Phe 
65                  70                  75                  80  


Pro Val Gly Leu Phe Ser Gly Ser Lys Ala Thr 
                85                  90      


<210> 8570
<211> 844
<212> PRT
<213> Homo sapiens

<400> 8570
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn Glu Glu Lys Ile Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Ile Val His Pro Ser Gln Glu Glu Asp Arg His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val Arg Leu Ser Arg Asp 
    210                 215                 220                 


Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro Asp Pro Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Ile Ile Glu Gln Leu Leu Ser Asn Ile Phe 
                245                 250                 255     


His Lys Glu Lys Asn Glu Ser Ala Ile Val Ser Ala Ile Gln Ile Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His Ile Glu 
        275                 280                 285             


Ile Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn Lys Ser 
    290                 295                 300                 


Val Leu Glu Ala Ile Arg Gly Arg Leu Gly Ser Phe His Glu Leu Leu 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Lys Ser Val Met Lys Thr Thr Trp Gly Val Leu 
                325                 330                 335     


Asp Pro Pro Val Gly Asn Thr Arg Leu Asn Val Ile Arg Leu Ile Ser 
            340                 345                 350         


Ser Leu Leu Gln Thr Asn Thr Ser Ser Ile Asn Gly Asp Leu Met Glu 
        355                 360                 365             


Leu Asn Ser Ile Gly Val Ile Leu Asn Met Phe Phe Lys Tyr Thr Trp 
    370                 375                 380                 


Asn Asn Phe Leu His Thr Gln Val Glu Ile Cys Ile Ala Leu Ile Leu 
385                 390                 395                 400 


Ala Ser Pro Phe Glu Asn Thr Glu Asn Ala Thr Ile Thr Asp Gln Asp 
                405                 410                 415     


Ser Thr Gly Asp Asn Leu Leu Leu Lys His Leu Phe Gln Lys Cys Gln 
            420                 425                 430         


Leu Ile Glu Arg Ile Leu Glu Ala Trp Glu Met Asn Glu Lys Lys Gln 
        435                 440                 445             


Ala Glu Gly Gly Arg Arg His Gly Tyr Met Gly His Leu Thr Arg Ile 
    450                 455                 460                 


Ala Asn Cys Ile Val His Ser Thr Asp Lys Gly Pro Asn Ser Ala Leu 
465                 470                 475                 480 


Val Gln Gln Leu Ile Lys Asp Leu Pro Asp Glu Val Arg Glu Arg Trp 
                485                 490                 495     


Glu Thr Phe Cys Thr Ser Ser Leu Gly Glu Thr Asn Lys Arg Asn Thr 
            500                 505                 510         


Val Asp Leu Ala Phe Ser Asp Tyr Gln Met Gln Gln Met Thr Ser Asn 
        515                 520                 525             


Phe Ile Asp Gln Phe Gly Phe Asn Asp Glu Lys Phe Ala Asp Gln Asp 
    530                 535                 540                 


Asp Ile Gly Asn Val Ser Phe Asp Arg Val Ser Asp Ile Asn Phe Thr 
545                 550                 555                 560 


Leu Asn Thr Asn Glu Ser Gly Asn Ile Ala Leu Phe Glu Ala Cys Cys 
                565                 570                 575     


Lys Glu Arg Ile Gln Gln Phe Asp Asp Gly Gly Ser Asp Glu Glu Asp 
            580                 585                 590         


Ile Trp Glu Glu Lys His Ile Ala Phe Thr Pro Glu Ser Gln Arg Arg 
        595                 600                 605             


Ser Ser Ser Gly Ser Thr Asp Ser Glu Glu Ser Thr Asp Ser Glu Glu 
    610                 615                 620                 


Glu Asp Gly Ala Lys Gln Asp Leu Phe Glu Pro Ser Ser Ala Asn Thr 
625                 630                 635                 640 


Glu Asp Lys Met Glu Val Asp Leu Ser Glu Pro Pro Asn Trp Ser Ala 
                645                 650                 655     


Asn Phe Asp Val Pro Met Glu Thr Thr His Gly Ala Pro Leu Asp Ser 
            660                 665                 670         


Val Gly Ser Asp Val Trp Ser Thr Glu Glu Pro Met Pro Thr Lys Glu 
        675                 680                 685             


Thr Gly Trp Ala Ser Phe Ser Glu Phe Thr Ser Ser Leu Ser Thr Lys 
    690                 695                 700                 


Asp Ser Leu Arg Ser Asn Ser Pro Val Glu Met Glu Thr Ser Thr Glu 
705                 710                 715                 720 


Pro Met Asp Pro Leu Thr Pro Ser Ala Ala Ala Leu Ala Val Gln Pro 
                725                 730                 735     


Glu Ala Ala Gly Ser Val Ala Met Glu Ala Ser Ser Asp Gly Glu Glu 
            740                 745                 750         


Asp Ala Glu Ser Thr Asp Lys Val Thr Glu Thr Val Met Asn Gly Gly 
        755                 760                 765             


Met Lys Glu Thr Leu Ser Leu Thr Val Asp Ala Lys Thr Glu Thr Ala 
    770                 775                 780                 


Val Phe Lys Ser Glu Glu Gly Lys Leu Ser Thr Ser Gln Asp Ala Ala 
785                 790                 795                 800 


Cys Lys Asp Ala Glu Glu Cys Pro Glu Thr Ala Glu Ala Lys Cys Ala 
                805                 810                 815     


Ala Pro Arg Pro Pro Ser Ser Ser Pro Glu Gln Arg Thr Gly Gln Pro 
            820                 825                 830         


Ser Ala Pro Gly Asp Thr Ser Val Asn Gly Pro Val 
        835                 840                 


<210> 8571
<211> 867
<212> PRT
<213> Homo sapiens

<400> 8571
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn Glu Glu Lys Ile Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Ile Val His Pro Ser Gln Glu Glu Asp Arg His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val Arg Leu Ser Arg Asp 
    210                 215                 220                 


Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro Asp Pro Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Ile Ile Glu Gln Leu Leu Ser Asn Ile Phe 
                245                 250                 255     


His Lys Glu Lys Asn Glu Ser Ala Ile Val Ser Ala Ile Gln Ile Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His Ile Glu 
        275                 280                 285             


Ile Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn Lys Ser 
    290                 295                 300                 


Val Leu Glu Ala Ile Arg Gly Arg Leu Gly Ser Phe His Glu Leu Leu 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Lys Ser Val Met Lys Thr Thr Trp Gly Val Leu 
                325                 330                 335     


Asp Pro Pro Val Gly Asn Thr Arg Leu Asn Val Ile Arg Leu Ile Ser 
            340                 345                 350         


Ser Leu Leu Gln Thr Asn Thr Ser Ser Ile Asn Gly Asp Leu Met Glu 
        355                 360                 365             


Leu Asn Ser Ile Gly Val Ile Leu Asn Met Phe Phe Lys Tyr Thr Trp 
    370                 375                 380                 


Asn Asn Phe Leu His Thr Gln Val Glu Ile Cys Ile Ala Leu Ile Leu 
385                 390                 395                 400 


Ala Ser Pro Phe Glu Asn Thr Glu Asn Ala Thr Ile Thr Asp Gln Asp 
                405                 410                 415     


Ser Thr Gly Asp Asn Leu Leu Leu Lys His Leu Phe Gln Lys Cys Gln 
            420                 425                 430         


Leu Ile Glu Arg Ile Leu Glu Ala Trp Glu Met Asn Glu Lys Lys Gln 
        435                 440                 445             


Ala Glu Gly Gly Arg Arg His Gly Tyr Met Gly His Leu Thr Arg Ile 
    450                 455                 460                 


Ala Asn Cys Ile Val His Ser Thr Asp Lys Gly Pro Asn Ser Ala Leu 
465                 470                 475                 480 


Val Gln Gln Leu Ile Lys Asp Leu Pro Asp Glu Val Arg Glu Arg Trp 
                485                 490                 495     


Glu Thr Phe Cys Thr Ser Ser Leu Gly Glu Thr Asn Lys Arg Asn Thr 
            500                 505                 510         


Val Asp Leu Val Thr Thr Cys His Ile His Ser Ser Ser Asp Asp Glu 
        515                 520                 525             


Ile Asp Phe Lys Glu Thr Gly Phe Ser Gln Asp Ser Ser Leu Gln Gln 
    530                 535                 540                 


Met Gln Gln Met Thr Ser Asn Phe Ile Asp Gln Phe Gly Phe Asn Asp 
545                 550                 555                 560 


Glu Lys Phe Ala Asp Gln Asp Asp Ile Gly Asn Val Ser Phe Asp Arg 
                565                 570                 575     


Val Ser Asp Ile Asn Phe Thr Leu Asn Thr Asn Glu Ser Gly Asn Ile 
            580                 585                 590         


Ala Leu Phe Glu Ala Cys Cys Lys Glu Arg Ile Gln Gln Phe Asp Asp 
        595                 600                 605             


Gly Gly Ser Asp Glu Glu Asp Ile Trp Glu Glu Lys His Ile Ala Phe 
    610                 615                 620                 


Thr Pro Glu Ser Gln Arg Arg Ser Ser Ser Gly Ser Thr Asp Ser Glu 
625                 630                 635                 640 


Glu Ser Thr Asp Ser Glu Glu Glu Asp Gly Ala Lys Gln Asp Leu Phe 
                645                 650                 655     


Glu Pro Ser Ser Ala Asn Thr Glu Asp Lys Met Glu Val Asp Leu Ser 
            660                 665                 670         


Glu Pro Pro Asn Trp Ser Ala Asn Phe Asp Val Pro Met Glu Thr Thr 
        675                 680                 685             


His Gly Ala Pro Leu Asp Ser Val Gly Ser Asp Val Trp Ser Thr Glu 
    690                 695                 700                 


Glu Pro Met Pro Thr Lys Glu Thr Gly Trp Ala Ser Phe Ser Glu Phe 
705                 710                 715                 720 


Thr Ser Ser Leu Ser Thr Lys Asp Ser Leu Arg Ser Asn Ser Pro Val 
                725                 730                 735     


Glu Met Glu Thr Ser Thr Glu Pro Met Asp Pro Leu Thr Pro Ser Ala 
            740                 745                 750         


Ala Ala Leu Ala Val Gln Pro Glu Ala Ala Gly Ser Val Ala Met Glu 
        755                 760                 765             


Ala Ser Ser Asp Gly Glu Glu Asp Ala Glu Ser Thr Asp Lys Val Thr 
    770                 775                 780                 


Glu Thr Val Met Asn Gly Gly Met Lys Glu Thr Leu Ser Leu Thr Val 
785                 790                 795                 800 


Asp Ala Lys Thr Glu Thr Ala Val Phe Lys Ser Glu Glu Gly Lys Leu 
                805                 810                 815     


Ser Thr Ser Gln Asp Ala Ala Cys Lys Asp Ala Glu Glu Cys Pro Glu 
            820                 825                 830         


Thr Ala Glu Ala Lys Cys Ala Ala Pro Arg Pro Pro Ser Ser Ser Pro 
        835                 840                 845             


Glu Gln Arg Thr Gly Gln Pro Ser Ala Pro Gly Asp Thr Ser Val Asn 
    850                 855                 860                 


Gly Pro Val 
865         


<210> 8572
<211> 57
<212> PRT
<213> Homo sapiens

<400> 8572
Met Thr Ser Lys Lys Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp 
1               5                   10                  15      


Ala Leu Ala Gly Leu Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln 
            20                  25                  30          


Gly His Arg Val Ala Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg 
        35                  40                  45              


Val Ala Leu Leu Ser Gly Gly Gly Ser 
    50                  55          


<210> 8573
<211> 902
<212> PRT
<213> Homo sapiens

<400> 8573
Met Phe Pro Ala Leu Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Glu Asp Phe Met Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys 
            20                  25                  30          


Ala Gln Arg Gly Ser Leu Pro Asn Ser Ala Thr His Gln His Val Arg 
        35                  40                  45              


Lys Asn Asn Pro Gln Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp 
    50                  55                  60                  


Asp Leu Ile Pro Asp Thr Leu Gln Lys Glu Lys Leu Leu Trp Pro Ile 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Val His Arg Gln Ile Glu Ala Ile Asn Arg Asp 
                85                  90                  95      


Phe His Ser Cys Leu Gly Trp Met Gln Trp Arg Gly Leu Ser Ser Leu 
            100                 105                 110         


Gln Pro Pro Pro Pro Arg Phe Lys Asp Ser Pro Ala Ser Ala Phe Arg 
        115                 120                 125             


Val Ala Gly Ile Thr Asp Ser His Met Leu Ser Leu Pro His Leu Arg 
    130                 135                 140                 


Ser Arg Gln Leu Leu Tyr Asp Glu Leu Asp Glu Val Asn Pro Arg Leu 
145                 150                 155                 160 


Arg Glu Pro Gln Glu Leu Phe Ser Ile Leu Ser Thr Lys Arg Pro Leu 
                165                 170                 175     


Gln Ala Pro Arg Trp Pro Ile Glu Cys Glu Val Ile Lys Glu Asn Ile 
            180                 185                 190         


His His Ile Glu Trp Ala Pro Pro Gln Pro Glu Tyr Phe Tyr Gln Pro 
        195                 200                 205             


Lys Gly Asn Glu Lys Val Pro Glu Ile Val Gly Glu Lys Lys Gly Thr 
    210                 215                 220                 


Val Val Tyr Gln Leu Asp Ser Val Pro Ile Glu Gly Ser Tyr Phe Thr 
225                 230                 235                 240 


Ser Ser Arg Val Gly Gly Lys Arg Gly Ile Val Lys Glu Leu Ala Val 
                245                 250                 255     


Thr Leu Gln Gly Pro Glu Asp Asn Thr Leu Leu Phe Glu Ser Arg Phe 
            260                 265                 270         


Glu Ser Gly Asn Leu Gln Lys Ala Val Arg Val Asp Thr Tyr Glu Tyr 
        275                 280                 285             


Glu Leu Thr Leu Arg Thr Asp Leu Tyr Thr Asn Lys His Thr Gln Trp 
    290                 295                 300                 


Phe Tyr Phe Arg Val Gln Asn Thr Arg Lys Asp Ala Thr Tyr Arg Phe 
305                 310                 315                 320 


Thr Ile Val Asn Leu Leu Lys Pro Lys Ser Leu Tyr Thr Val Gly Met 
                325                 330                 335     


Lys Pro Leu Leu Tyr Ser Gln Leu Asp Ala Asn Thr Arg Asn Ile Gly 
            340                 345                 350         


Trp Arg Arg Glu Gly Asn Glu Ile Lys Tyr Tyr Lys Asn Asn Thr Asp 
        355                 360                 365             


Asp Gly Gln Gln Pro Phe Tyr Cys Leu Thr Trp Thr Ile Gln Phe Pro 
    370                 375                 380                 


Tyr Asp Gln Asp Thr Cys Phe Phe Ala His Phe Tyr Pro Tyr Thr Tyr 
385                 390                 395                 400 


Thr Asp Leu Gln Cys Tyr Leu Leu Ser Val Ala Asn Asn Pro Ile Gln 
                405                 410                 415     


Ser Gln Phe Cys Lys Leu Gln Thr Leu Cys Arg Ser Leu Ala Gly Asn 
            420                 425                 430         


Thr Val Tyr Leu Leu Thr Ile Thr Asn Pro Ser Gln Thr Pro Gln Glu 
        435                 440                 445             


Ala Ala Ala Lys Lys Ala Val Val Leu Ser Ala Arg Val His Pro Gly 
    450                 455                 460                 


Glu Ser Asn Gly Ser Trp Val Met Lys Gly Phe Leu Asp Phe Ile Leu 
465                 470                 475                 480 


Ser Asn Ser Pro Asp Ala Gln Leu Leu Arg Asp Ile Phe Val Phe Lys 
                485                 490                 495     


Val Leu Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg 
            500                 505                 510         


Cys Ser Leu Ala Gly Arg Asp Leu Asn Arg His Tyr Lys Thr Ile Leu 
        515                 520                 525             


Lys Glu Ser Phe Pro Cys Ile Trp Tyr Thr Arg Asn Met Ile Lys Arg 
    530                 535                 540                 


Leu Leu Glu Glu Arg Glu Val Leu Leu Tyr Cys Asp Phe His Gly His 
545                 550                 555                 560 


Ser Arg Lys Asn Asn Ile Phe Leu Tyr Gly Cys Asn Asn Asn Asn Arg 
                565                 570                 575     


Lys Tyr Trp Leu His Glu Arg Val Phe Pro Leu Met Leu Cys Lys Asn 
            580                 585                 590         


Ala Pro Asp Lys Phe Ser Phe His Ser Cys Asn Phe Lys Val Gln Lys 
        595                 600                 605             


Cys Lys Glu Gly Thr Gly Arg Val Val Met Trp Arg Met Gly Ile Leu 
    610                 615                 620                 


Asn Ser Tyr Thr Met Glu Ser Thr Phe Gly Gly Ser Thr Leu Gly Asn 
625                 630                 635                 640 


Lys Arg Asp Thr His Phe Thr Ile Glu Asp Leu Lys Ser Leu Gly Tyr 
                645                 650                 655     


His Val Cys Asp Thr Leu Leu Asp Phe Cys Asp Pro Asp Gln Met Lys 
            660                 665                 670         


Phe Thr Gln Cys Leu Ala Glu Leu Lys Glu Leu Leu Arg Gln Glu Ile 
        675                 680                 685             


His Lys Lys Phe His Glu Leu Gly Gln Asp Val Asp Leu Glu Gly Ser 
    690                 695                 700                 


Trp Ser Asp Ile Ser Leu Ser Asp Ile Glu Ser Ser Thr Ser Gly Ser 
705                 710                 715                 720 


Asp Ser Ser Leu Ser Asp Gly Leu Pro Val His Leu Ala Asn Ile Ala 
                725                 730                 735     


Asp Glu Leu Thr Gln Lys Lys Lys Met Phe Lys Lys Lys Lys Lys Lys 
            740                 745                 750         


Ser Leu Gln Thr Arg Lys Gln Arg Asn Glu Gln Tyr Gln Lys Lys Asn 
        755                 760                 765             


Leu Met Gln Lys Leu Lys Leu Thr Glu Asp Thr Ser Glu Lys Ala Gly 
    770                 775                 780                 


Phe Ala Ser Thr Leu Gln Lys Gln Pro Thr Phe Phe Lys Asn Ser Glu 
785                 790                 795                 800 


Asn Ser Ser Phe Leu Pro Met Lys Asn Glu Asn Pro Arg Leu Asn Glu 
                805                 810                 815     


Thr Asn Leu Asn Arg Arg Asp Lys Asp Thr Pro Leu Asp Pro Ser Met 
            820                 825                 830         


Ala Thr Leu Ile Leu Pro Lys Asn Lys Gly Arg Met Gln Asn Lys Lys 
        835                 840                 845             


Pro Gly Phe Thr Val Ser Cys Ser Pro Lys Arg Thr Ile Asn Ser Ser 
    850                 855                 860                 


Gln Glu Pro Ala Pro Gly Met Lys Pro Asn Trp Pro Arg Ser Arg Tyr 
865                 870                 875                 880 


Pro Ala Thr Lys Arg Gly Cys Ala Ala Met Ala Ala Tyr Pro Ser Leu 
                885                 890                 895     


His Ile Tyr Thr Tyr Pro 
            900         


<210> 8574
<211> 178
<212> PRT
<213> Homo sapiens

<400> 8574
Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe 
        115                 120                 125             


Gly Val Thr Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser 
    130                 135                 140                 


Asn Phe Leu Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu 
145                 150                 155                 160 


Val Ala Cys Gln Ile Val Leu Pro Asp Pro Ala Thr Gln Asp Ala Lys 
                165                 170                 175     


Thr Lys 
        


<210> 8575
<211> 146
<212> PRT
<213> Homo sapiens

<400> 8575
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser Glu 
    130                 135                 140                 


Ala Gly 
145     


<210> 8576
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8576
Met Ala Gly Arg Pro Leu Arg Ile Gly Asp Gln Leu Val Leu Glu Glu 
1               5                   10                  15      


Asp Tyr Asp Glu Thr Tyr Ile Pro Ser Glu Gln Glu Ile Leu Glu Phe 
            20                  25                  30          


Ala Arg Glu Ile Gly Ile Asp Pro Ile Lys Glu Pro Glu Leu Met Trp 
        35                  40                  45              


Leu Ala Arg Glu Gly Ile Val Ala Pro Leu Pro Gly Glu Trp Lys Pro 
    50                  55                  60                  


Cys Gln Asp Ile Thr Gly Asp Ile Tyr Tyr Phe Asn Phe Ala Asn Gly 
65                  70                  75                  80  


Gln Ser Met Trp Asp His Pro Cys Asp Glu His Tyr Arg Ser Leu Val 
                85                  90                  95      


Ile Gln Glu Arg Ala Lys Leu Ser Thr Ser Gly Ala Ile Lys Lys Lys 
            100                 105                 110         


Lys Lys Lys 
        115 


<210> 8577
<211> 396
<212> PRT
<213> Homo sapiens

<400> 8577
Met Arg Thr Ser Tyr Thr Val Thr Leu Pro Glu Asp Pro Pro Ala Ala 
1               5                   10                  15      


Pro Phe Pro Ala Leu Ala Lys Glu Leu Arg Pro Arg Ser Pro Leu Ser 
            20                  25                  30          


Pro Ser Leu Leu Leu Ser Thr Phe Val Gly Leu Leu Leu Asn Lys Ala 
        35                  40                  45              


Lys Asn Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly 
    50                  55                  60                  


Asn Thr Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg 
65                  70                  75                  80  


Glu Leu Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His 
                85                  90                  95      


His Gly Ser Asn Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu 
            100                 105                 110         


Ile Gln Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser 
        115                 120                 125             


Glu Phe Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr 
    130                 135                 140                 


Asn Gln Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu 
145                 150                 155                 160 


His Asn Glu Val Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu 
                165                 170                 175     


Asn Leu Asp His Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg 
            180                 185                 190         


Lys Tyr Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly 
        195                 200                 205             


Gln Leu Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr 
    210                 215                 220                 


Val Phe Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly 
225                 230                 235                 240 


Tyr Pro Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu 
                245                 250                 255     


Asp Val Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly 
            260                 265                 270         


Arg Lys Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile 
        275                 280                 285             


Leu Val Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser 
    290                 295                 300                 


Lys Leu Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg 
305                 310                 315                 320 


Glu Phe Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala 
                325                 330                 335     


Val Ser Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr 
            340                 345                 350         


Cys Arg Ser Pro Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser 
        355                 360                 365             


Val Thr Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu 
    370                 375                 380                 


Leu Phe Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
385                 390                 395     


<210> 8578
<211> 210
<212> PRT
<213> Homo sapiens

<400> 8578
Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu 
            100                 105                 110         


Ser Gly Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu 
        115                 120                 125             


Pro Gly Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala 
    130                 135                 140                 


Ala Asn Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp 
145                 150                 155                 160 


Gln Asp Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro 
                165                 170                 175     


Asn His Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu 
            180                 185                 190         


Asp Lys Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly 
        195                 200                 205             


Leu Gln 
    210 


<210> 8579
<211> 475
<212> PRT
<213> Homo sapiens

<400> 8579
Met Glu Leu Trp Gln Ala Ala Leu Ser Thr Leu Asn Pro Asn Pro Thr 
1               5                   10                  15      


Asp Ser Cys Pro Leu Tyr Leu Asn Tyr Ala Thr Val Ala Ala Leu Pro 
            20                  25                  30          


Cys Arg Val Ser Arg His Asn Ser Pro Ser Ala Ala His Phe Ile Thr 
        35                  40                  45              


Arg Leu Val Arg Thr Cys Leu Pro Pro Gly Ala His Arg Cys Ile Val 
    50                  55                  60                  


Met Val Cys Glu Gln Pro Glu Val Phe Ala Ser Ala Cys Ala Leu Ala 
65                  70                  75                  80  


Arg Ala Phe Pro Leu Phe Thr His Arg Ser Gly Ala Ser Arg Arg Leu 
                85                  90                  95      


Glu Lys Lys Thr Val Thr Val Glu Phe Phe Leu Val Gly Gln Asp Asn 
            100                 105                 110         


Gly Pro Val Glu Val Ser Thr Leu Gln Cys Leu Ala Asn Ala Thr Asp 
        115                 120                 125             


Gly Val Arg Leu Ala Ala Arg Ile Val Asp Thr Pro Cys Asn Glu Met 
    130                 135                 140                 


Asn Thr Asp Thr Phe Leu Glu Glu Ile Asn Lys Val Gly Lys Glu Leu 
145                 150                 155                 160 


Gly Ile Ile Pro Thr Ile Ile Arg Asp Glu Glu Leu Lys Thr Arg Gly 
                165                 170                 175     


Phe Gly Gly Ile Tyr Gly Val Gly Lys Ala Ala Leu His Pro Pro Ala 
            180                 185                 190         


Leu Ala Val Leu Ser His Thr Pro Asp Gly Ala Thr Gln Thr Ile Ala 
        195                 200                 205             


Trp Val Gly Lys Gly Ile Val Tyr Asp Thr Gly Gly Leu Ser Ile Lys 
    210                 215                 220                 


Gly Lys Thr Thr Met Pro Gly Met Lys Arg Asp Cys Gly Gly Ala Ala 
225                 230                 235                 240 


Ala Val Leu Gly Ala Phe Arg Ala Ala Ile Lys Gln Gly Phe Lys Asp 
                245                 250                 255     


Asn Leu His Ala Val Phe Cys Leu Ala Glu Asn Ser Val Gly Pro Asn 
            260                 265                 270         


Ala Thr Arg Pro Asp Asp Ile His Leu Leu Tyr Ser Gly Lys Thr Val 
        275                 280                 285             


Glu Ile Asn Asn Thr Asp Ala Glu Gly Arg Leu Val Leu Ala Asp Gly 
    290                 295                 300                 


Val Ser Tyr Ala Cys Lys Asp Leu Gly Ala Asp Ile Ile Leu Asp Met 
305                 310                 315                 320 


Ala Thr Leu Thr Gly Ala Gln Gly Ile Ala Thr Gly Lys Tyr His Ala 
                325                 330                 335     


Ala Val Leu Thr Asn Ser Ala Glu Trp Glu Ala Ala Cys Val Lys Ala 
            340                 345                 350         


Gly Arg Lys Cys Gly Asp Leu Val His Pro Leu Val Tyr Cys Pro Glu 
        355                 360                 365             


Leu His Phe Ser Glu Phe Thr Ser Ala Val Ala Asp Met Lys Asn Ser 
    370                 375                 380                 


Val Ala Asp Arg Asp Asn Ser Pro Ser Ser Cys Ala Gly Leu Phe Ile 
385                 390                 395                 400 


Ala Ser His Ile Gly Phe Asp Trp Pro Gly Val Trp Val His Leu Asp 
                405                 410                 415     


Ile Ala Ala Pro Val His Ala Gly Glu Arg Ala Thr Gly Phe Gly Val 
            420                 425                 430         


Ala Leu Leu Leu Ala Leu Phe Gly Arg Ala Ser Glu Asp Pro Leu Leu 
        435                 440                 445             


Asn Leu Val Ser Pro Leu Gly Cys Glu Val Asp Val Glu Glu Gly Asp 
    450                 455                 460                 


Leu Gly Arg Asp Ser Lys Arg Arg Arg Leu Val 
465                 470                 475 


<210> 8580
<211> 178
<212> PRT
<213> Homo sapiens

<400> 8580
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser Glu 
    130                 135                 140                 


Ala Asp Val Arg Val Leu Glu Glu Gln Ala Gln Asn Leu Gly Leu Glu 
145                 150                 155                 160 


Gly Thr Leu Val Ser Leu Ala Arg Val Pro Gln Ala Arg Ala Val Arg 
                165                 170                 175     


Val Val 
        


<210> 8581
<211> 630
<212> PRT
<213> Homo sapiens

<400> 8581
Met Glu Lys Val Leu Gly Cys Glu Leu Leu Lys Gly Leu Asn Val Leu 
1               5                   10                  15      


Asp Leu Gly Leu Asn Met Glu Ile Leu Glu Glu Gln Met Leu His Glu 
            20                  25                  30          


Ile Leu Cys Arg Glu Tyr Pro Glu Leu Glu Thr Arg Trp Gln Asp Leu 
        35                  40                  45              


Lys Ile Arg Ala Leu Asp Thr Cys Lys Ala Val Glu Ala Ala Glu Glu 
    50                  55                  60                  


Arg Leu Leu Thr Met Leu Leu Phe Gln Asn Pro Lys Arg Gln Lys Pro 
65                  70                  75                  80  


Ala Lys Phe Leu Arg Asn Ile Val Arg Ala Gln Gly Lys Leu Cys Gln 
                85                  90                  95      


Leu Arg Ala His Cys Glu Glu Leu Glu Gly Gln Lys Leu Gln Glu Met 
            100                 105                 110         


Val Leu Trp Ala Pro Tyr Arg Pro Val Val Trp His Gly Met Ala Met 
        115                 120                 125             


Val Lys Ala Leu Ser Gln Leu Gln Asn Leu Leu Pro Leu Phe Cys Met 
    130                 135                 140                 


Ser Pro Glu Asn Trp Leu Ala Val Thr Lys Gln Ala Leu Asp Ser Met 
145                 150                 155                 160 


Lys Pro Arg Glu Ile Asn His Gly Glu Asp Leu Ala Ser His Leu Leu 
                165                 170                 175     


Gln Leu Arg Ala His Leu Thr Arg Gln Leu Leu Gly Ser Thr Val Thr 
            180                 185                 190         


Ala Leu Gly Leu Thr Gln Val Pro Leu Val Gly Ala Leu Gly Ala Leu 
        195                 200                 205             


Ala Leu Leu Gln Ala Thr Gly Lys Ala Ser Glu Leu Glu Arg Leu Ala 
    210                 215                 220                 


Leu Trp Pro Gly Leu Ala Ala Ser Pro Ser Thr Val His Ser Lys Pro 
225                 230                 235                 240 


Val Ser Asp Val Ala Arg Pro Ala Trp Leu Gly Pro Lys Ala Trp His 
                245                 250                 255     


Glu Cys Glu Met Leu Glu Leu Leu Pro Pro Phe Val Gly Leu Cys Ala 
            260                 265                 270         


Ser Leu Ala Gly His Ser Ser Ala Trp Gln Ala Tyr Leu Ser Leu Ser 
        275                 280                 285             


Ser Thr Val Leu Gly Pro Ala Pro Gly Pro Gly Pro Glu Pro Leu Ser 
    290                 295                 300                 


Leu Leu Gln Lys Leu Ile Leu Trp Arg Val Leu Arg Pro Glu Cys Leu 
305                 310                 315                 320 


Ala Gly Ala Leu Ala Asp Phe Thr Thr Ser Leu Leu Gly Arg Pro Leu 
                325                 330                 335     


Asp Glu Asn Thr Tyr Ala Pro Thr Met Pro Phe Lys His Ser Gln Ala 
            340                 345                 350         


Thr Gln Pro Met Leu Ile Leu Leu Pro Pro Pro Gly His Pro Ser Ala 
        355                 360                 365             


Thr Leu His Pro Leu Thr Val Ile Gln Lys Leu Ala Ala Lys Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Lys Gln Leu Gln Val Ile Ala Leu Gly Ser Glu Ala Trp 
385                 390                 395                 400 


Asp Pro Val Ser Val Val Val Ser Thr Leu Ser Gln Ala Met Tyr Glu 
                405                 410                 415     


Gly His Trp Leu Val Leu Asp Asn Cys His Leu Met Pro His Trp Pro 
            420                 425                 430         


Lys Glu Leu Leu Gln Leu Leu Leu Glu Leu Leu Gly Arg Ala Lys Val 
        435                 440                 445             


Val Ala Asp Leu Glu Ser Glu Gln Leu Leu Asp Gln Pro Glu Ser Arg 
    450                 455                 460                 


Asn Val Ser Thr Val His Arg Asp Phe Arg Leu Trp Leu Ile Val Pro 
465                 470                 475                 480 


Ala Glu Ser Ser Ala Ser Leu Pro Ala Val Leu Thr Gln His Ser Met 
                485                 490                 495     


Pro Val Phe Trp Asn Gln Ser Leu Glu Leu Gly His Val Leu Ile Asp 
            500                 505                 510         


Ser Val Glu Leu Ala Gln Gln Val Leu Tyr Met Gln Pro Pro Thr Gln 
        515                 520                 525             


Ala Leu Pro Leu Leu Leu Leu His Gly Leu Leu Leu His Arg Gln Leu 
    530                 535                 540                 


Tyr Gly Thr Arg Leu Gln Ala His Arg Gly Arg Trp Ser Gln Val Thr 
545                 550                 555                 560 


Leu Thr Gln Val Leu Gln Thr Gln Asp Gln Leu Trp Ala Ser Leu Ser 
                565                 570                 575     


Asn Pro Arg Ala Ala Met Gln Glu Leu Ala Gly Glu Thr Leu Pro Leu 
            580                 585                 590         


Pro Leu Gly Val Ile Ser Pro Gln Glu Ser Leu Glu Glu Gly Gly Gly 
        595                 600                 605             


Gly Ile Gln Phe Thr Ala Leu Val Leu Ala Val Val Glu Thr Glu Gly 
    610                 615                 620                 


Thr Gly Thr Glu Arg Leu 
625                 630 


<210> 8582
<211> 495
<212> PRT
<213> Homo sapiens

<400> 8582
Met Glu Leu His Gly Gly Asn Arg Gly Gly Tyr Gln Pro Lys Ala Leu 
1               5                   10                  15      


Glu Gln Ser Gly Cys Trp Leu Trp Gln Ala Ala Leu Ser Thr Leu Asn 
            20                  25                  30          


Pro Asn Pro Thr Asp Ser Cys Pro Leu Tyr Leu Asn Tyr Ala Thr Val 
        35                  40                  45              


Ala Ala Leu Pro Cys Arg Val Ser Arg His Asn Ser Pro Ser Ala Ala 
    50                  55                  60                  


His Phe Ile Thr Arg Leu Val Arg Thr Cys Leu Pro Pro Gly Ala His 
65                  70                  75                  80  


Arg Cys Ile Val Met Val Cys Glu Gln Pro Glu Val Phe Ala Ser Ala 
                85                  90                  95      


Cys Ala Leu Ala Arg Ala Phe Pro Leu Phe Thr His Arg Ser Gly Ala 
            100                 105                 110         


Ser Arg Arg Leu Glu Lys Lys Thr Val Thr Val Glu Phe Phe Leu Val 
        115                 120                 125             


Gly Gln Asp Asn Gly Pro Val Glu Val Ser Thr Leu Gln Cys Leu Ala 
    130                 135                 140                 


Asn Ala Thr Asp Gly Val Arg Leu Ala Ala Arg Ile Val Asp Thr Pro 
145                 150                 155                 160 


Cys Asn Glu Met Asn Thr Asp Thr Phe Leu Glu Glu Ile Asn Lys Val 
                165                 170                 175     


Gly Lys Glu Leu Gly Ile Ile Pro Thr Ile Ile Arg Asp Glu Glu Leu 
            180                 185                 190         


Lys Thr Arg Gly Phe Gly Gly Ile Tyr Gly Val Gly Lys Ala Ala Leu 
        195                 200                 205             


His Pro Pro Ala Leu Ala Val Leu Ser His Thr Pro Asp Gly Ala Thr 
    210                 215                 220                 


Gln Thr Ile Ala Trp Val Gly Lys Gly Ile Val Tyr Asp Thr Gly Gly 
225                 230                 235                 240 


Leu Ser Ile Lys Gly Lys Thr Thr Met Pro Gly Met Lys Arg Asp Cys 
                245                 250                 255     


Gly Gly Ala Ala Ala Val Leu Gly Ala Phe Arg Ala Ala Ile Lys Gln 
            260                 265                 270         


Gly Phe Lys Asp Asn Leu His Ala Val Phe Cys Leu Ala Glu Asn Ser 
        275                 280                 285             


Val Gly Pro Asn Ala Thr Arg Pro Asp Asp Ile His Leu Leu Tyr Ser 
    290                 295                 300                 


Gly Lys Thr Val Glu Ile Asn Asn Thr Asp Ala Glu Gly Arg Leu Val 
305                 310                 315                 320 


Leu Ala Asp Gly Val Ser Tyr Ala Cys Lys Asp Leu Gly Ala Asp Ile 
                325                 330                 335     


Ile Leu Asp Met Ala Thr Leu Thr Gly Ala Gln Gly Ile Ala Thr Gly 
            340                 345                 350         


Lys Tyr His Ala Ala Val Leu Thr Asn Ser Ala Glu Trp Glu Ala Ala 
        355                 360                 365             


Cys Val Lys Ala Gly Arg Lys Cys Gly Asp Leu Val His Pro Leu Val 
    370                 375                 380                 


Tyr Cys Pro Glu Leu His Phe Ser Glu Phe Thr Ser Ala Val Ala Asp 
385                 390                 395                 400 


Met Lys Asn Ser Val Ala Asp Arg Asp Asn Ser Pro Ser Ser Cys Ala 
                405                 410                 415     


Gly Leu Phe Ile Ala Ser His Ile Gly Phe Asp Trp Pro Gly Val Trp 
            420                 425                 430         


Val His Leu Asp Ile Ala Ala Pro Val His Ala Gly Glu Arg Ala Thr 
        435                 440                 445             


Gly Phe Gly Val Ala Leu Leu Leu Ala Leu Phe Gly Arg Ala Ser Glu 
    450                 455                 460                 


Asp Pro Leu Leu Asn Leu Val Ser Pro Leu Gly Cys Glu Val Asp Val 
465                 470                 475                 480 


Glu Glu Gly Asp Leu Gly Arg Asp Ser Lys Arg Arg Arg Leu Val 
                485                 490                 495 


<210> 8583
<211> 205
<212> PRT
<213> Homo sapiens

<400> 8583
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro 
        195                 200                 205 


<210> 8584
<211> 38
<212> PRT
<213> Homo sapiens

<400> 8584
Met Ala Ala Phe Lys Leu Asp Phe Leu Pro Glu Met Met Val Asp His 
1               5                   10                  15      


Cys Ser Leu Asn Ser Ser Pro Val Ser Lys Lys Met Asn Gly Thr Leu 
            20                  25                  30          


Asp His Pro Asp Gln Pro 
        35              


<210> 8585
<211> 517
<212> PRT
<213> Homo sapiens

<400> 8585
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Ser Ser Ser Arg Leu Ser Tyr Gln 
            260                 265                 270         


Pro Ala Ala Leu Gly Val Gly Ser Ala Asp Leu Ala Tyr Pro Val Val 
        275                 280                 285             


Phe Ala Ala Gly Leu Asn Ala Thr His Pro His Gln Leu Met Val Pro 
    290                 295                 300                 


Gly Lys Glu Gly Gly Val Pro Leu Ala Pro Asn Gln Pro Val His Gly 
305                 310                 315                 320 


Thr Gln Ala Asp Gln Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg 
                325                 330                 335     


Thr His Cys Ala Ala Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val 
            340                 345                 350         


Ser Asn Ser Ser Glu Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr 
        355                 360                 365             


Ile Phe Val Arg Lys Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln 
    370                 375                 380                 


Val Thr Leu Thr Ser Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys 
385                 390                 395                 400 


Asn Leu Glu Leu Glu Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser 
                405                 410                 415     


Pro Glu Thr Glu Ser Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser 
            420                 425                 430         


Ser Gly Gly Ser Ser Gly Asn Thr His Asp Asp Phe Val Met Ile Asp 
        435                 440                 445             


Phe Lys Pro Ala Phe Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly 
    450                 455                 460                 


Thr Phe Tyr Arg Glu Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser 
465                 470                 475                 480 


Ile Asp Ile Gly Ala Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro 
                485                 490                 495     


Glu Lys Leu Ala Val His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe 
            500                 505                 510         


Val Glu Thr Leu Gln 
        515         


<210> 8586
<211> 255
<212> PRT
<213> Homo sapiens

<400> 8586
Met Glu Arg Ser Gly Gln Arg Val Thr Thr Trp Asp Cys Asp Gln Gly 
1               5                   10                  15      


Lys His Ser Asp Ser Ala Gln Lys Asn Glu Arg Glu Ser Ile Arg Gln 
            20                  25                  30          


Lys Leu Ala Leu Gly Ser Phe Phe Asp Asp Gly Pro Gly Ile Tyr Thr 
        35                  40                  45              


Ser Cys Ser Lys Ser Gly Lys Pro Ser Leu Ser Ser Arg Leu Gln Ser 
    50                  55                  60                  


Gly Met Asn Leu Gln Ile Cys Phe Val Asn Asp Ser Gly Ser Asp Lys 
65                  70                  75                  80  


Asp Ser Asp Ala Asp Asp Ser Lys Thr Glu Thr Ser Leu Asp Thr Pro 
                85                  90                  95      


Leu Ser Pro Met Ser Lys Gln Ser Ser Ser Tyr Ser Asp Arg Asp Thr 
            100                 105                 110         


Thr Glu Glu Glu Ser Glu Ser Leu Asp Asp Met Asp Phe Leu Thr Arg 
        115                 120                 125             


Gln Lys Lys Leu Gln Ala Glu Ala Lys Met Ala Leu Ala Met Ala Lys 
    130                 135                 140                 


Pro Met Ala Lys Met Gln Val Glu Val Glu Lys Gln Asn Arg Lys Lys 
145                 150                 155                 160 


Ser Pro Val Ala Asp Leu Leu Pro His Met Pro His Ile Ser Glu Cys 
                165                 170                 175     


Leu Met Lys Arg Ser Leu Lys Pro Thr Asp Leu Arg Asp Met Thr Ile 
            180                 185                 190         


Gly Gln Leu Gln Val Ile Val Asn Asp Leu His Ser Gln Ile Glu Ser 
        195                 200                 205             


Leu Asn Glu Glu Leu Val Gln Leu Leu Leu Ile Arg Asp Glu Leu His 
    210                 215                 220                 


Thr Glu Gln Asp Ala Met Leu Val Asp Ile Glu Asp Leu Thr Arg His 
225                 230                 235                 240 


Ala Glu Ser Gln Gln Lys His Met Ala Glu Lys Met Pro Ala Lys 
                245                 250                 255 


<210> 8587
<211> 25
<212> PRT
<213> Homo sapiens

<400> 8587
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala 
            20                  25  


<210> 8588
<211> 119
<212> PRT
<213> Homo sapiens

<400> 8588
Met Val Leu Glu Gly Asn Pro Glu Val Gly Ser Pro Arg Thr Ser Asp 
1               5                   10                  15      


Leu Gln His Arg Gly Asn Lys Gly Ser Cys Val Leu Ser Ser Pro Gly 
            20                  25                  30          


Glu Asp Ala Gln Pro Gly Glu Glu Pro Ile Lys Tyr Gly Glu Leu Ile 
        35                  40                  45              


Val Leu Gly Cys Cys Glu Glu Gly Gly Glu Glu Thr Glu Ala Gln Arg 
    50                  55                  60                  


Gly Glu Val Thr Gly Pro Arg Ala His Ser Cys Tyr Asn Gly Cys Leu 
65                  70                  75                  80  


Ala Ser Gly Asp Lys Gly Arg Arg Arg Ser Arg Leu Ala Leu Ser Arg 
                85                  90                  95      


Arg Ser His Ala Asn Gly Val Lys Pro Asp Val Met His His Ile Ser 
            100                 105                 110         


Thr Pro Leu Val Ser Lys Ala 
        115                 


<210> 8589
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8589
Met Ala Gly Arg Pro Leu Arg Ile Gly Asp Gln Leu Val Leu Glu Glu 
1               5                   10                  15      


Asp Tyr Asp Glu Thr Tyr Ile Pro Ser Glu Gln Glu Ile Leu Glu Phe 
            20                  25                  30          


Ala Arg Glu Ile Gly Ile Asp Pro Ile Lys Glu Pro Glu Leu Met Trp 
        35                  40                  45              


Leu Ala Arg Glu Gly Ile Val Ala Pro Leu Pro Gly Glu Trp Lys Pro 
    50                  55                  60                  


Cys Gln Asp Ile Thr Gly Asp Ile Tyr Tyr Phe Asn Phe Ala Asn Gly 
65                  70                  75                  80  


Gln Ser Met Trp Asp His Pro Cys Asp Glu His Tyr Arg Ser Leu Val 
                85                  90                  95      


Ile Gln Glu Arg Ala Lys Leu Ser Thr Ser Gly Ala Ile Lys Lys Lys 
            100                 105                 110         


Lys Lys Lys 
        115 


<210> 8590
<211> 156
<212> PRT
<213> Homo sapiens

<400> 8590
Met Ser Ser Val Gln Ser Gln Gln Glu Gln Leu Ser Gln Ser Asp Pro 
1               5                   10                  15      


Ser Pro Ser Pro Asn Ser Cys Ser Ser Phe Glu Leu Ile Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Leu Tyr Glu Pro Val Ser Pro His Trp Phe Tyr Cys Lys 
        35                  40                  45              


Ile Ile Asp Ser Lys Glu Thr Trp Ile Pro Phe Asn Ser Glu Asp Ser 
    50                  55                  60                  


Gln Gln Leu Glu Glu Ala Tyr Ser Ser Gly Lys Gly Cys Asn Gly Arg 
65                  70                  75                  80  


Val Val Pro Thr Asp Gly Gly Arg Tyr Asp Val His Leu Gly Glu Arg 
                85                  90                  95      


Met Arg Tyr Ala Val Tyr Trp Asp Glu Leu Ala Ser Glu Val Arg Arg 
            100                 105                 110         


Cys Thr Trp Phe Tyr Lys Gly Asp Lys Asp Asn Lys Tyr Val Pro Tyr 
        115                 120                 125             


Ser Glu Ser Phe Ser Gln Val Leu Glu Glu Thr Tyr Met Leu Ala Val 
    130                 135                 140                 


Thr Leu Asp Glu Trp Lys Lys Lys Leu Glu Ser Pro 
145                 150                 155     


<210> 8591
<211> 4753
<212> PRT
<213> Homo sapiens

<400> 8591
Met Val Pro Glu Glu Arg Arg Val Gly Leu Ser Ser Asp Glu Thr Ser 
1               5                   10                  15      


Ser Asp Ser Leu Lys Ser Trp His Ser Ile Cys Val Leu Asp Ser Lys 
            20                  25                  30          


Glu Gln Pro Leu Ala Cys Gln Gln Lys Gln Arg Gln Phe Val Lys Pro 
        35                  40                  45              


Val Thr Glu Ser Glu Gln Pro Thr Val Leu Glu Leu Leu Leu Ala Glu 
    50                  55                  60                  


Leu Arg Thr Leu Phe Ser Ala Val Leu Gln Asp Ser Ser Pro Ala Ala 
65                  70                  75                  80  


Trp Arg Tyr Leu His Ala Val Leu Gly Leu Leu Pro Pro Tyr Arg Glu 
                85                  90                  95      


Leu Leu Val Gly His Leu Asp Leu Leu Pro Phe Leu Glu Gln Leu Tyr 
            100                 105                 110         


Cys Trp Ala Pro Trp Val Gln Thr His Leu His Leu Asp Leu Leu Gly 
        115                 120                 125             


Ala Ile Val Gln Ala Phe Pro Pro Asp Ser Ser Leu Leu Asp Ser Ala 
    130                 135                 140                 


Ser His Ala Asp Cys Cys Pro Gln Lys Arg Arg Leu His His Arg Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Cys Pro Phe Val Gln Ala Gln Trp Ser Arg Gln Gln 
                165                 170                 175     


Val Lys Glu Glu Leu Ala Thr Trp Leu Arg Pro Leu Thr Leu Pro Glu 
            180                 185                 190         


Leu Gln Arg Cys Leu Gly Ile Val Gly Ala Gln Val Ala Leu Glu Glu 
        195                 200                 205             


Ala Val Trp Leu Asp Gly Leu Ser Leu Leu Pro Leu Ala Leu Ala Ala 
    210                 215                 220                 


Asp Ile Pro Val Arg Tyr Glu Ser Ser Asp Thr Asp Asn Ala Glu Val 
225                 230                 235                 240 


Glu Pro Val Gly Arg Lys Glu Thr Arg Ser Gln Leu Asp Tyr Glu Val 
                245                 250                 255     


Pro Arg Glu Lys Ala Phe Gln Lys Ser Ser Thr Gly Phe Ser Pro Glu 
            260                 265                 270         


Thr Ser Phe Leu Asp Ser Gln Val Met Thr Ala Leu Lys Met Glu Arg 
        275                 280                 285             


Tyr Leu Lys Lys Ile His Phe Leu Tyr Leu Asn Val Ala Pro Ser Arg 
    290                 295                 300                 


Tyr Phe Arg Pro Tyr Ser Leu Met Val Val Pro Pro Asp Lys Val Asn 
305                 310                 315                 320 


Pro Glu His Tyr Ile Phe Ser Pro Phe Gly Ile Leu His Val His Pro 
                325                 330                 335     


Val Glu Gly Ser Glu Thr Met Thr Leu Gly Thr Trp His His His Cys 
            340                 345                 350         


Val Leu Trp Gln Gln Leu Gln Phe Ile Pro Phe Phe Lys Tyr Cys Leu 
        355                 360                 365             


Leu Arg Lys Ser Phe Thr Cys Trp Lys Lys Asn Val Arg Leu Gln Gly 
    370                 375                 380                 


Leu His Arg Leu Gln Lys Phe Leu Glu Asn His Leu Leu Leu Ala Val 
385                 390                 395                 400 


Pro His Phe Gly Ala Gly Leu Leu His Ile Ser Arg Leu Leu Gln Glu 
                405                 410                 415     


Leu His Ser Val Ser Trp Leu Pro Gln Glu Leu Asp Arg Cys Tyr Glu 
            420                 425                 430         


Leu Leu Asp Leu Gln Thr Ala Leu Ala Glu Glu Lys His Lys Ala Leu 
        435                 440                 445             


Arg Leu Leu His Arg Cys Leu Asn Leu Cys Thr Ser Ile Leu Arg Leu 
    450                 455                 460                 


Val His Glu Asp Thr Tyr His Met Gln Gln Cys Leu Gln Glu Arg Val 
465                 470                 475                 480 


Gln Asn Cys Asp Arg Ile Arg Thr Gly Gln Gly Ser Ile Tyr Leu Gln 
                485                 490                 495     


Arg Val Gln His Lys Gln Leu Glu Gln Lys Leu Lys Gln Ala Glu Ala 
            500                 505                 510         


Trp Trp Leu Gln Leu Gly Lys Phe Ala Arg Leu Val Asp Tyr Met Ile 
        515                 520                 525             


Cys Gln Ser Leu Ile Ser Val Leu Glu Glu Gln Ile Thr Ser Phe Val 
    530                 535                 540                 


Ala Asn Ile Leu Gln Ala Pro Arg Gln Lys Pro Phe Leu Ser Ser Gln 
545                 550                 555                 560 


Leu Val Phe Asp Asp His Gly Gln Leu Ser His Val Pro Cys Val Glu 
                565                 570                 575     


Asn Met Ile Gln Thr Leu Thr Gly Gly Leu Gln Ser Val Lys Thr Ser 
            580                 585                 590         


Ala Leu Gln Val Val Gln Ser Ala Asp Leu Lys Thr Ser Ser Asp Ser 
        595                 600                 605             


Leu Tyr Ser Glu Glu Glu Asp Glu Glu Glu Asp Ser Lys Asp Glu Phe 
    610                 615                 620                 


Leu Met Pro Lys Phe Gln Gly Gln Pro Ser Asp Ala Val Ser Ile Phe 
625                 630                 635                 640 


Cys Gly Pro Asn Val Gly Leu Val Trp Pro Trp Lys Ser His Pro Ile 
                645                 650                 655     


Ala Gly Ile Leu Glu Val Arg Gly Cys Arg Leu Arg Gly Gln Tyr Phe 
            660                 665                 670         


Pro His Asn Tyr Lys Gln Leu Glu Glu Asp Leu Asp Asn Asn Pro Lys 
        675                 680                 685             


Ile Gln Gln Ala Leu Asn Ile Gln Gln Val Leu Leu Glu Gly Val Leu 
    690                 695                 700                 


Cys Lys Val Gln Glu Phe Cys Arg Glu His His Trp Ile Thr Gly Ile 
705                 710                 715                 720 


Tyr Glu Phe Leu Gln Ser Trp Gly Pro Gln Lys Leu Glu Asp Met Arg 
                725                 730                 735     


Gly Gly Pro Ile Lys Asn Tyr Val Thr Leu Val Ser Arg Leu Asn Val 
            740                 745                 750         


Trp Gln Ala Arg Val Ser Ser Met Pro Ile Glu Leu Leu Thr Lys Gly 
        755                 760                 765             


Gly Leu Leu Leu Leu Ser Cys His Asp Val Gln Ala Glu Met Glu Ser 
    770                 775                 780                 


Lys Leu Asn Ser Ile Arg Lys Asp Ile Leu Ala His Val Gln Asn Glu 
785                 790                 795                 800 


Cys Trp Asn Leu Ser Gln Gln Leu Met Thr Glu Leu Thr Asp Phe Met 
                805                 810                 815     


His Ile Phe Arg Thr Ile Asn Ser Asp Ile His Ala Ile Ala Gln Cys 
            820                 825                 830         


Thr Gln Lys Leu Asn Glu Ala Asn Glu Gln Tyr Val Glu Leu Glu Glu 
        835                 840                 845             


Arg Met Glu Tyr Val Arg Ala Leu His Glu Leu Ile Arg Asn His Phe 
    850                 855                 860                 


Ser Leu Phe Ser Ala Glu Asn Glu Ala Leu Asp Ile Ser Val Arg Arg 
865                 870                 875                 880 


Gln Phe Gly Glu Ser Pro Ile Pro Pro Cys Pro Pro Pro Pro Gln Pro 
                885                 890                 895     


His Leu Leu His Cys Pro Leu Leu Ala Pro Gln Leu Leu Asp Met Trp 
            900                 905                 910         


Glu Ala Phe Gln Phe Glu Lys Ser Gln Ala Ser Glu Phe Leu Leu Ser 
        915                 920                 925             


Lys Arg His Ala Ile Met Pro Lys Leu Gln Gln Leu Met Ala Ala Ala 
    930                 935                 940                 


Leu Ala Glu Leu Glu Gly Leu Leu Ala Lys Ala Leu Ser Gly Pro Phe 
945                 950                 955                 960 


Met Asp Pro Thr Gln Asp Gln Arg Ser Thr Glu His Gln Leu Val Ser 
                965                 970                 975     


Leu Glu Arg Gln Phe Gln Asn Thr Val Ser Asp Leu Ser Glu Leu His 
            980                 985                 990         


His Ala Tyr Ala Ile Phe Thr Glu  Asp Glu Thr Pro Val  Pro Leu Pro 
        995                 1000                 1005             


Ile Cys  Gly Thr Arg Pro Ile  Val Gln Gln Gln Arg  Ile Trp His 
    1010                 1015                 1020             


Leu Tyr  Arg Val Ile Ser Glu  Asn Ile Ser Glu Trp  Lys Cys Met 
    1025                 1030                 1035             


Ala Phe  Ala Lys Phe Ser Pro  Ala Met Ala Gln Glu  Lys Thr Glu 
    1040                 1045                 1050             


Gly Trp  Leu Thr Glu Ala Ala  Arg Met Ser Thr Thr  Leu Glu Leu 
    1055                 1060                 1065             


His Ser  Pro Val Leu Gln His  Cys Met Arg Ile Leu  Gly Glu Phe 
    1070                 1075                 1080             


Arg Ser  Tyr Leu Pro Leu Leu  Thr Lys Leu Gly Ser  Leu His Pro 
    1085                 1090                 1095             


Gln Ser  Leu Asn Cys Gln Cys  Leu Leu Arg Ala Leu  Gly Leu Gly 
    1100                 1105                 1110             


Ser Leu  Gln Thr Ile Glu Leu  Leu Thr Leu Gly Gln  Leu Leu Thr 
    1115                 1120                 1125             


Tyr Pro  Leu Leu Glu Phe Ala  Asp Arg Ile Asn Gln  Val Trp Gln 
    1130                 1135                 1140             


Asn Glu  Asn Glu Arg Ile His  Ala Gln Glu Thr Ile  Arg Arg Leu 
    1145                 1150                 1155             


Gln Arg  Tyr Trp Glu Ala Arg  Gln Leu Arg Leu Leu  Asn Phe Ile 
    1160                 1165                 1170             


Leu His  Val Pro Tyr Glu Pro  Pro Ala Ser Glu Arg  Ser Lys Arg 
    1175                 1180                 1185             


Gln Val  Leu Arg Ser Pro Gln  Trp Glu Val Val Asp  Lys Asp Ser 
    1190                 1195                 1200             


Gly Thr  Phe Ile Leu Ser Asp  Tyr Ser Asn Leu Gln  Asp Ser Ile 
    1205                 1210                 1215             


Gln Glu  Ser Leu Gln Val Leu  Ser Lys Ile Leu Ala  Ile Glu Lys 
    1220                 1225                 1230             


Ser Gly  Asp Leu Asn Lys Ile  Ala Leu Glu Trp Val  Ala Ile Met 
    1235                 1240                 1245             


His Gly  Leu Gly Ala Leu Leu  Glu Val Trp Leu Thr  Phe Gln Gln 
    1250                 1255                 1260             


Lys Trp  Ile Phe Leu Asn Lys  Val Leu His Glu Met  Lys Ile Gln 
    1265                 1270                 1275             


Phe Pro  Asn Ala Asp Leu Asn  Ser Arg Phe Lys Val  Met Asp Asp 
    1280                 1285                 1290             


Gln Tyr  Arg Thr Leu Met Arg  Ile Ser Val Ala Asp  Pro Met Val 
    1295                 1300                 1305             


Leu Ser  Leu Val Val Pro Ser  Ala Glu Arg Ser Pro  Tyr Phe Gln 
    1310                 1315                 1320             


Gly Gln  Gln Leu Gln Gln Leu  Leu Gln Ala Gly Ser  Val Glu Leu 
    1325                 1330                 1335             


Glu Gly  Ile Ile Met Ser Leu  Glu Ser Val Leu Tyr  Gly Val Cys 
    1340                 1345                 1350             


Ala His  Phe Pro Arg Leu Phe  Phe Leu Ser Asp Ser  Glu Leu Val 
    1355                 1360                 1365             


Ala Leu  Leu Ala Ala Arg Leu  Glu Ser Cys Glu Ala  Gln Leu Trp 
    1370                 1375                 1380             


Val Arg  Arg Cys Phe Pro His  Val His Ala Val Ser  Phe Arg Ser 
    1385                 1390                 1395             


Cys Pro  Thr Gly Glu Lys Asn  Thr Asp Asp Trp Glu  Ser Ser Pro 
    1400                 1405                 1410             


Asn Thr  Gln Thr Gln Val Glu  Ala Leu Ala Val Leu  Gly Ala Gly 
    1415                 1420                 1425             


Gly Glu  Glu Val Lys Leu Gln  Gly Pro Leu Pro Leu  His Pro Asp 
    1430                 1435                 1440             


Leu Pro  Lys Trp Leu Ala Ser  Leu Glu Lys Cys Leu  Arg Leu Ala 
    1445                 1450                 1455             


Leu Val  His Met Leu Gln Gly  Cys Val Ala Ala Arg  Leu Ala Arg 
    1460                 1465                 1470             


Gly Pro  Ser Leu Gly Glu Ala  Leu Lys Gln Leu Pro  Lys Gln Asn 
    1475                 1480                 1485             


Lys Leu  Tyr Leu Gln Leu Tyr  Val Gln His Trp Ile  Asp Leu Val 
    1490                 1495                 1500             


Gln Ala  Phe Pro Trp Gln Cys  Val Leu Val Ala Glu  Glu Val Val 
    1505                 1510                 1515             


Trp Arg  Ala Glu Met Glu Glu  Ala Leu Leu Glu Trp  Gly Thr Leu 
    1520                 1525                 1530             


Ala Met  Val Ser Met His Met  Arg Lys Leu Glu Val  Leu Val Asn 
    1535                 1540                 1545             


Phe Met  Arg Ala Gln Arg Ala  Ser Gln Gly Gly Gln  Ser Leu Pro 
    1550                 1555                 1560             


Ser Val  Arg Gln Thr Ser Leu  Leu Ser Ala Leu Leu  Val Met Ala 
    1565                 1570                 1575             


Val Thr  His Arg Asp Ile Ala  Gln Leu Leu Glu Gln  His Gln Val 
    1580                 1585                 1590             


Ser Asp  Leu Thr Asp Phe His  Trp Val Arg Gln Leu  Lys Tyr His 
    1595                 1600                 1605             


Leu Gly  Ser Pro His Ile Ile  Pro Lys Ser Pro Leu  Gln Ser Leu 
    1610                 1615                 1620             


Lys Thr  Ile Ala Ser Ser Glu  Pro Ser Leu Ser Pro  Ala Ala Cys 
    1625                 1630                 1635             


Trp Ile  Asp Val Leu Gly Arg  Ser Phe Leu Tyr Asn  Tyr Glu Tyr 
    1640                 1645                 1650             


Leu Gly  Pro Arg Leu Gly Pro  Leu Pro Ser Leu Leu  Pro Glu Arg 
    1655                 1660                 1665             


Pro Ala  Leu Val Leu Leu Leu  Ala Leu Glu Glu Val  Ala Cys Gly 
    1670                 1675                 1680             


Thr Val  Leu Gly Pro Asn Gly  Val Gly Lys Arg Ala  Ile Val Asn 
    1685                 1690                 1695             


Ser Leu  Ala Gln Ala Leu Gly  Arg Gln Leu Val Met  Leu Pro Cys 
    1700                 1705                 1710             


Ser Pro  Gln Ile Glu Ala Gln  Cys Leu Ser Asn Tyr  Leu Asn Gly 
    1715                 1720                 1725             


Ala Leu  Gln Gly Gly Ala Trp  Leu Leu Leu Glu Lys  Val His Gln 
    1730                 1735                 1740             


Leu Pro  Pro Gly Leu Leu Ser  Ala Leu Gly Gln Arg  Leu Gly Glu 
    1745                 1750                 1755             


Leu His  His Leu Tyr Ala Pro  Leu Tyr Gln Glu Ala  Ser Arg Asn 
    1760                 1765                 1770             


Thr Ser  Thr Ile Asp Pro Thr  Gln Pro Gln Leu Leu  Gly Ser Ser 
    1775                 1780                 1785             


Phe Phe  Glu Lys His His Val  Ser Val Arg Leu Gly  Tyr Gly Cys 
    1790                 1795                 1800             


Leu Leu  Val Leu Arg Ala Leu  Ser Ser Ala Val Pro  Ala Asn Leu 
    1805                 1810                 1815             


His Leu  Leu Leu Arg Pro Val  Ala Leu Ala Leu Pro  Asp Leu Arg 
    1820                 1825                 1830             


Gln Val  Ala Glu Leu Thr Leu  Leu Gly Ala Gly Met  Arg Asp Ala 
    1835                 1840                 1845             


Phe Gln  Met Ala Thr Arg Leu  Ser Lys Phe Phe Ser  Leu Glu Arg 
    1850                 1855                 1860             


Glu Leu  Val Ser Gly Pro Leu  Pro Cys Arg Leu Pro  Leu Leu Lys 
    1865                 1870                 1875             


Gln Ile  Leu Glu Asp Thr Ile  Arg Thr Leu Asn Val  Thr Lys Glu 
    1880                 1885                 1890             


Glu Pro  Lys Cys Gln Lys Pro  Arg Ser Leu Ala Ala  Ile Glu Glu 
    1895                 1900                 1905             


Ala Ala  Leu Leu Arg Ser Pro  Leu Phe Ser Ile Leu  Asn Gly Leu 
    1910                 1915                 1920             


His Leu  His Asn Leu Arg Gly  Leu Leu Cys Ala Leu  Phe Pro Ser 
    1925                 1930                 1935             


Ala Ser  Gln Val Leu Ala Glu  Pro Met Thr Tyr Lys  Leu Met Lys 
    1940                 1945                 1950             


Pro Leu  Val Val Glu Glu Leu  Gln Gln Val Gly Leu  Asp Pro Ser 
    1955                 1960                 1965             


Pro Asp  Ile Leu Gly Ser Leu  Glu Gln Leu Ser Gln  Ala Leu Ser 
    1970                 1975                 1980             


Arg Ala  Ser Gly Ile Leu Leu  Leu Gly Pro Ala Gly  Ser Gly Lys 
    1985                 1990                 1995             


Thr Thr  Cys Trp His Ser Leu  Phe Lys Ile Gln Asn  Arg Leu Ala 
    2000                 2005                 2010             


Ala Met  Glu Asp Thr Ser Thr  Gln Gly Cys Gln Pro  Val Glu Ile 
    2015                 2020                 2025             


Thr His  Leu Tyr Pro Ser Gly  Leu Ser Pro Gln Glu  Phe Leu Gly 
    2030                 2035                 2040             


Trp Leu  Glu Gly Ser Cys Trp  His His Gly Ile Phe  Pro Lys Val 
    2045                 2050                 2055             


Leu Arg  Ala Ala Gly Gln Cys  Asn Asn Met Gly Gln  Lys Arg Gln 
    2060                 2065                 2070             


Thr Glu  Glu Ser Ile Gly Ile  Gln His Trp Ile Ile  Cys Asp Gly 
    2075                 2080                 2085             


Ala Ser  Asn Gly Ala Trp Leu  Asp Ser Ile Thr Cys  Leu Leu Ser 
    2090                 2095                 2100             


Glu Leu  Pro Gln Leu Ser Leu  Pro Ser Gly Gln Gln  Ile Ala Arg 
    2105                 2110                 2115             


Pro Pro  Gly Thr Phe Leu Leu  Met Glu Val Ala Asp  Thr Thr Gly 
    2120                 2125                 2130             


Ile Ser  Pro Thr Val Val Gly  Cys Cys Ala Leu Val  Trp Cys Gly 
    2135                 2140                 2145             


Gly Glu  Gln Thr Trp Gln Cys  Ile Leu Ser Ala Leu  Met Ala Ser 
    2150                 2155                 2160             


Leu Pro  Tyr Glu Tyr Arg Leu  Gln His Arg Thr Val  Ala Glu Leu 
    2165                 2170                 2175             


Asn His  Met Ala Glu Val Leu  Val Pro Ala Thr Leu  Arg Phe Leu 
    2180                 2185                 2190             


Thr Cys  Gln Gly Val Ser Ser  Leu Leu Gln Val His  Gly Gln Gln 
    2195                 2200                 2205             


Ala Val  Cys Ala Gly Val Ala  Glu Val Thr Ser Met  Ala Arg Ile 
    2210                 2215                 2220             


Leu His  Ser Leu Leu Asp Leu  His Leu Arg Leu Lys  Glu Glu Lys 
    2225                 2230                 2235             


Ala Pro  Gly Pro Glu Asp Leu  Ser Tyr Ser Asp Pro  Val Ala Gln 
    2240                 2245                 2250             


Ser Phe  Arg Ser Ser Lys Ser  Ser Phe Leu Asn Arg  Ser Gln Val 
    2255                 2260                 2265             


Asp Ser  Asp Asp Val Pro Asp  Lys Cys Arg Glu His  Leu Leu Ala 
    2270                 2275                 2280             


Val Ser  Ser Phe Leu Phe Ala  Leu Ile Trp Gly Phe  Gly Ala His 
    2285                 2290                 2295             


Leu Pro  Ser Arg Phe Trp Pro  Ile Phe Asp Thr Phe  Ile Arg Asp 
    2300                 2305                 2310             


Ser Ile  Ser Arg Leu Ser Asn  Tyr Pro Glu Pro Pro  Pro Ser Ala 
    2315                 2320                 2325             


Leu Val  Phe Asp Leu His Val  Ser Pro Glu Asp Gly  Thr Leu Val 
    2330                 2335                 2340             


Pro Phe  Thr Gly Gln Tyr Leu  Ser Ser His Ile Lys  Gly Thr Leu 
    2345                 2350                 2355             


Gly Thr  Phe His Pro Ser Ile  Gln Thr Glu Arg Leu  Leu Tyr Val 
    2360                 2365                 2370             


Val Asp  Leu Leu Leu Ser Gly  Gly Gln Pro Val Leu  Leu Ala Gly 
    2375                 2380                 2385             


Glu Ala  Ala Thr Gly Lys Ser  Ala Phe Val Glu Val  Leu Val Glu 
    2390                 2395                 2400             


Pro His  His Pro Tyr Ile Tyr  Ser Pro Ile His Pro  Ala Phe Ser 
    2405                 2410                 2415             


Ser Ser  His Leu Arg Leu Leu  Leu Ser Arg Gly Ile  Gln Gly Gln 
    2420                 2425                 2430             


Thr Gln  Ala Ser Pro Gln Pro  Gly His His Gln Asp  Ser Lys Pro 
    2435                 2440                 2445             


Ser Leu  Leu Phe Leu Leu Glu  Asp Leu His Leu Ala  Thr Ser Asp 
    2450                 2455                 2460             


Pro Glu  Lys Ser Cys Gln Pro  Val Leu Glu Thr Leu  Arg Gln Ala 
    2465                 2470                 2475             


Met Asp  Gly Thr Val Tyr Ala  His Ser Thr Leu Glu  Leu Gln Thr 
    2480                 2485                 2490             


Leu Gln  Pro Thr Val Asn Phe  Leu Ala Thr Val Thr  Val Pro Gly 
    2495                 2500                 2505             


Tyr Cys  Glu Arg Pro Leu Cys  Pro Arg Leu Phe Arg  Leu Phe Thr 
    2510                 2515                 2520             


Val Leu  Ala Leu Glu Ser Met  Thr Gln Ala Thr Leu  Leu Glu Arg 
    2525                 2530                 2535             


His Val  Pro Ile Ile Gln Ala  Trp Leu Glu Arg Phe  Pro Ser Val 
    2540                 2545                 2550             


Glu Arg  Glu Arg Ala Leu Ala  Arg Gly Leu Val Arg  Ala Ser Val 
    2555                 2560                 2565             


Glu Ala  Trp Glu Ala Val Cys  Asn Cys Phe Met Pro  Ser Pro Leu 
    2570                 2575                 2580             


His Pro  His Tyr His Phe Ser  Leu His Ser Val Ser  His Leu Leu 
    2585                 2590                 2595             


Ser Ser  Leu Gln Leu Leu Pro  Asn Arg Thr Gly Ser  Arg Gly Phe 
    2600                 2605                 2610             


Val Asp  Tyr Pro Asn His Gln  Glu His Leu Arg Arg  Val Ser Gly 
    2615                 2620                 2625             


Leu Arg  Gly Thr Cys Leu Thr  Val Met Met Ala Thr  Arg Asn Val 
    2630                 2635                 2640             


Val Arg  Leu Trp Leu His Glu  Ala Gln Arg Thr Phe  Cys Asp Arg 
    2645                 2650                 2655             


Leu Asp  Ser Pro Arg Glu Arg  Ser Tyr Cys Ala Lys  Leu Leu Leu 
    2660                 2665                 2670             


Val Val  Ala Gln Ser Val Phe  Cys Cys Gly Pro Gly  Pro Gln His 
    2675                 2680                 2685             


Leu Gly  Lys Asp His Gln Glu  Ser Glu Glu Glu Glu  Glu Glu Glu 
    2690                 2695                 2700             


Arg Val  Pro Glu Val Glu Ser  Glu Gly Glu Leu Ala  Gln Trp Glu 
    2705                 2710                 2715             


Asp Phe  Ser Asn Ser Asn Ser  Glu Thr Glu Glu Glu  Glu Glu Pro 
    2720                 2725                 2730             


Tyr Gly  Leu Gln Val Ala Arg  Val Ser Asn Ser Arg  Asp Pro Ser 
    2735                 2740                 2745             


Leu Thr  Pro Ser Ile Gly Pro  Val Ser Arg Gly Met  Lys Glu Ser 
    2750                 2755                 2760             


Ile Ser  His Lys Ile Arg Gln  Glu Lys Gly Thr Arg  Ala Ser Asn 
    2765                 2770                 2775             


Tyr Arg  Leu Gln Val Arg Arg  Ser Phe Lys Thr Trp  Trp Gln Lys 
    2780                 2785                 2790             


Lys Pro  Gln Met Asp Leu Ile  Ser Pro Leu Leu Leu  Pro Val Leu 
    2795                 2800                 2805             


Leu Leu  His Pro Gln Glu Lys  Pro Ser Asp Leu Val  Phe Ser Gln 
    2810                 2815                 2820             


Glu Leu  Ile Leu Gly Pro Asn  Ser Glu Thr Pro Asn  Leu Tyr Leu 
    2825                 2830                 2835             


Glu Arg  Gln Trp Glu Lys Leu  Glu Glu Gln Leu Ala  Thr Ser Ala 
    2840                 2845                 2850             


Ala Gln  Leu Lys Leu Ser Pro  His Leu Ala Arg Cys  His Ser Met 
    2855                 2860                 2865             


Ala Gln  His Val Ala Arg Leu  Val Arg Val Leu Ala  Arg Pro Arg 
    2870                 2875                 2880             


Gln His  Gly Leu Leu Leu Ser  Gly Ala Leu Gly Thr  Gly Arg His 
    2885                 2890                 2895             


Thr Ala  Ile Thr Leu Ala Ser  Ser Ile Cys Gln Ala  His Phe Phe 
    2900                 2905                 2910             


His Leu  Pro Ser Gly Ser Glu  Glu Ala Ile Leu Gln  Cys Leu Arg 
    2915                 2920                 2925             


Asp Ala  Ser Trp His Ala Gly  Met Leu Ser Gln Pro  Val Ala Leu 
    2930                 2935                 2940             


Leu Val  Pro Ser Gly Val Asp  Leu Thr Thr Leu His  Arg Leu Leu 
    2945                 2950                 2955             


Ala Leu  Ala Thr Ser Gly Ser  Phe Pro Gly Gln Tyr  Thr Glu Ala 
    2960                 2965                 2970             


Asp Leu  Asp Arg Ile Gly Glu  His Leu Pro Arg Glu  Asn Leu Gly 
    2975                 2980                 2985             


Val Lys  Gln Asn Ile Lys Lys  Glu Met Val Leu Gln  Arg Phe His 
    2990                 2995                 3000             


Gln Gln  Val Cys Ser His Leu  His Leu Phe Phe Leu  Ile Gly Asp 
    3005                 3010                 3015             


Lys Gln  Ala His Lys Gln Leu  Pro Ser Thr Leu Phe  Leu Arg Leu 
    3020                 3025                 3030             


Leu Gln  Leu Ala Thr Ala Ser  Ile Asp Arg Tyr Glu  Pro Trp Asp 
    3035                 3040                 3045             


Gln Ala  Ala Leu Ala Lys Val  Ala Gln His His Leu  Glu Gly Ala 
    3050                 3055                 3060             


Gln Ser  Val Pro Leu Asp Asp  Gly Ser Trp Lys Tyr  Pro Asp Leu 
    3065                 3070                 3075             


Gln Ala  Ser Ile Pro Ser Val  Ala Lys Ala Met Ala  Leu Ile His 
    3080                 3085                 3090             


Leu Ser  Ala Thr His Tyr His  Glu His Leu Cys Pro  Ala Leu Pro 
    3095                 3100                 3105             


Leu Val  Thr Pro Lys Thr Phe  Leu Asp Phe Leu Asp  Thr Phe Leu 
    3110                 3115                 3120             


Met Leu  Gln Gln Gln Thr Ile  Leu Lys Ile Lys Asn  Lys Ala Gln 
    3125                 3130                 3135             


Arg Val  Gln Asn Ala Leu Glu  Asn Leu Arg Met Leu  Ile Lys Glu 
    3140                 3145                 3150             


His Gly  Thr His Ala Asn Leu  Ile Phe Asp Leu Glu  Gln Gln Leu 
    3155                 3160                 3165             


Lys Asp  Ser Gly Lys Ser Leu  Ser Met Phe Gln Gln  Gln Leu Glu 
    3170                 3175                 3180             


Gln Ser  Lys Leu Leu Tyr Lys  Gln Gln Leu Glu Glu  Cys Arg His 
    3185                 3190                 3195             


Gln Glu  Asn Leu Ile Glu Asn  Leu Ala Arg Gln Arg  Asp Ala Leu 
    3200                 3205                 3210             


Gln Ala  Gln Arg Glu Ala Phe  Leu Glu Gln Met Ser  Lys Ala Phe 
    3215                 3220                 3225             


Leu Glu  Pro Leu Ser Gln Leu  Gln Val Ala Asp Phe  Glu Glu Ile 
    3230                 3235                 3240             


Arg Ser  Tyr Arg Ala Pro Pro  Glu Ser Val Val Arg  Val Thr Asp 
    3245                 3250                 3255             


Ala Met  Cys Asp Leu Phe His  His Glu Thr Gly Trp  Ala Ser Ala 
    3260                 3265                 3270             


Lys Gln  Leu Leu Cys Thr Glu  Asp Phe Tyr Gln Glu  Leu Val Phe 
    3275                 3280                 3285             


Phe Pro  Lys Glu Lys Ile Thr  Asp Ser Glu Leu Ile  Lys Leu His 
    3290                 3295                 3300             


Leu Ile  Leu Lys Ala Pro Gly  Met Asp Asp Ala Ala  Leu Arg Ala 
    3305                 3310                 3315             


Val Ser  Arg Pro Ala Ala Ser  Leu Ala Ala Trp Leu  Trp Ala Val 
    3320                 3325                 3330             


Leu His  Tyr Gly Leu Ala His  Cys Arg Gly Leu Pro  Thr Asp Leu 
    3335                 3340                 3345             


Leu Leu  Gln Gln Val Glu Ala  Thr Leu Thr Arg Glu  Gln Ala Arg 
    3350                 3355                 3360             


Leu Gly  Tyr Tyr Gln Phe Gln  Ala Gln Glu Thr Leu  Glu His Asn 
    3365                 3370                 3375             


Leu Ala  Leu Ala Lys Met Val  Glu Asp Ala Gln Ala  Ser His Asn 
    3380                 3385                 3390             


Cys Val  Ala Lys Thr Leu Ser  Gln Ala Gln Cys Gly  Gln Tyr His 
    3395                 3400                 3405             


Lys Trp  Pro Met Lys Ala Ala  Leu Leu Thr Pro Met  Arg Ala Trp 
    3410                 3415                 3420             


Thr Thr  Gln Leu Gln Lys Leu  Lys Gly Arg Cys Met  Thr Val Phe 
    3425                 3430                 3435             


Gly Asp  Thr Leu Leu Cys Ser  Ala Ala Ile Ile Tyr  Leu Gly Pro 
    3440                 3445                 3450             


Phe Pro  Pro Leu Arg Arg Gln  Glu Leu Leu Asp Glu  Trp Leu Ala 
    3455                 3460                 3465             


Leu Cys  Arg Gly Phe Gln Glu  Ala Leu Gly Pro Asp  Asp Val Ala 
    3470                 3475                 3480             


Gln Ala  Leu Lys Arg Lys Gln  Lys Ser Val Ser Ile  Pro Pro Lys 
    3485                 3490                 3495             


Asn Pro  Leu Leu Ala Thr His  Ser Pro Phe Ser Ile  Leu Ser Leu 
    3500                 3505                 3510             


Leu Ser  Ser Glu Ser Glu Gln  Tyr Gln Trp Asp Gly  Asn Leu Lys 
    3515                 3520                 3525             


Pro Gln  Ala Lys Ser Ala His  Leu Ala Gly Leu Leu  Leu Arg Ser 
    3530                 3535                 3540             


Pro Thr  His Tyr Ser Ser Cys  Arg Trp Pro Leu Leu  Leu Asp Pro 
    3545                 3550                 3555             


Ser Asn  Glu Ala Leu Ile Trp  Leu Asp Pro Leu Pro  Leu Glu Glu 
    3560                 3565                 3570             


Asn Arg  Ser Phe Ala Pro Ala  Leu Thr Glu Gly Arg  Gly Lys Gly 
    3575                 3580                 3585             


Leu Met  Arg Asn Gln Lys Arg  Glu Ser Lys Thr Asp  Met Lys Glu 
    3590                 3595                 3600             


Glu Asp  Asp Glu Ser Glu Glu  Ser Asn Glu Ala Glu  Asp Gln Thr 
    3605                 3610                 3615             


Lys Glu  Gln Lys Ala Glu Glu  Arg Lys Asn Glu Gln  Glu Lys Glu 
    3620                 3625                 3630             


Gln Glu  Glu Asn Glu Glu Lys  Glu Glu Glu Lys Thr  Glu Ser Gln 
    3635                 3640                 3645             


Gly Ser  Lys Pro Ala Tyr Glu  Thr Gln Leu Pro Ser  Leu Pro Tyr 
    3650                 3655                 3660             


Leu Ser  Val Leu Ser Gly Ala  Asp Pro Glu Leu Gly  Ser Gln Leu 
    3665                 3670                 3675             


Gln Glu  Ala Ala Ala Cys Gly  Leu Pro Val Leu Leu  Thr Asn Val 
    3680                 3685                 3690             


Glu Leu  Gly Leu Gly Cys Glu  Glu Leu Gln Trp Leu  Leu Gln Arg 
    3695                 3700                 3705             


Glu Gln  Leu Ser Pro Pro Gln  Val Gln Pro Gly Phe  Cys Leu Tyr 
    3710                 3715                 3720             


Leu Ser  Thr Thr Leu Ser Leu  Cys Ala Met Glu Lys  Val Leu Gly 
    3725                 3730                 3735             


Cys Glu  Leu Leu Lys Gly Leu  Asn Val Leu Asp Leu  Gly Leu Asn 
    3740                 3745                 3750             


Met Glu  Ile Leu Glu Glu Gln  Met Leu His Glu Ile  Leu Cys Arg 
    3755                 3760                 3765             


Glu Tyr  Pro Glu Leu Glu Thr  Arg Trp Gln Asp Leu  Lys Ile Arg 
    3770                 3775                 3780             


Ala Leu  Asp Thr Cys Lys Ala  Val Glu Ala Ala Glu  Glu Arg Leu 
    3785                 3790                 3795             


Leu Thr  Met Leu Leu Phe Gln  Asn Pro Lys Arg Gln  Lys Pro Ala 
    3800                 3805                 3810             


Lys Phe  Leu Arg Asn Ile Val  Arg Ala Gln Gly Lys  Leu Cys Gln 
    3815                 3820                 3825             


Leu Arg  Ala His Cys Glu Glu  Leu Glu Gly Gln Lys  Leu Gln Glu 
    3830                 3835                 3840             


Met Val  Leu Trp Ala Pro Tyr  Arg Pro Val Val Trp  His Gly Met 
    3845                 3850                 3855             


Ala Met  Val Lys Ala Leu Ser  Gln Leu Gln Asn Leu  Leu Pro Leu 
    3860                 3865                 3870             


Phe Cys  Met Ser Pro Glu Asn  Trp Leu Ala Val Thr  Lys Gln Ala 
    3875                 3880                 3885             


Leu Asp  Ser Met Lys Pro Arg  Glu Ile Asn His Gly  Glu Asp Leu 
    3890                 3895                 3900             


Ala Ser  His Leu Leu Gln Leu  Arg Ala His Leu Thr  Arg Gln Leu 
    3905                 3910                 3915             


Leu Gly  Ser Thr Val Thr Ala  Leu Gly Leu Thr Gln  Val Pro Leu 
    3920                 3925                 3930             


Val Gly  Ala Leu Gly Ala Leu  Ala Leu Leu Gln Ala  Thr Gly Lys 
    3935                 3940                 3945             


Ala Ser  Glu Leu Glu Arg Leu  Ala Leu Trp Pro Gly  Leu Ala Ala 
    3950                 3955                 3960             


Ser Pro  Ser Thr Val His Ser  Lys Pro Val Ser Asp  Val Ala Arg 
    3965                 3970                 3975             


Pro Ala  Trp Leu Gly Pro Lys  Ala Trp His Glu Cys  Glu Met Leu 
    3980                 3985                 3990             


Glu Leu  Leu Pro Pro Phe Val  Gly Leu Cys Ala Ser  Leu Ala Gly 
    3995                 4000                 4005             


His Ser  Ser Ala Trp Gln Ala  Tyr Leu Ser Leu Ser  Ser Thr Val 
    4010                 4015                 4020             


Leu Gly  Pro Ala Pro Gly Pro  Gly Pro Glu Pro Leu  Ser Leu Leu 
    4025                 4030                 4035             


Gln Lys  Leu Ile Leu Trp Arg  Val Leu Arg Pro Glu  Cys Leu Ala 
    4040                 4045                 4050             


Gly Ala  Leu Ala Asp Phe Thr  Thr Ser Leu Leu Gly  Arg Pro Leu 
    4055                 4060                 4065             


Asp Glu  Asn Thr Tyr Ala Pro  Thr Met Pro Phe Lys  His Ser Gln 
    4070                 4075                 4080             


Ala Thr  Gln Pro Met Leu Ile  Leu Leu Pro Pro Pro  Gly His Pro 
    4085                 4090                 4095             


Ser Ala  Thr Leu His Pro Leu  Thr Val Ile Gln Lys  Leu Ala Ala 
    4100                 4105                 4110             


Lys Tyr  Gln Gln Gly Gln Lys  Gln Leu Gln Val Ile  Ala Leu Gly 
    4115                 4120                 4125             


Ser Glu  Ala Trp Asp Pro Val  Ser Val Val Val Ser  Thr Leu Ser 
    4130                 4135                 4140             


Gln Ala  Met Tyr Glu Gly His  Trp Leu Val Leu Asp  Asn Cys His 
    4145                 4150                 4155             


Leu Met  Pro His Trp Pro Lys  Glu Leu Leu Gln Leu  Leu Leu Glu 
    4160                 4165                 4170             


Leu Leu  Gly Arg Ala Lys Val  Val Ala Asp Leu Glu  Ser Glu Gln 
    4175                 4180                 4185             


Leu Leu  Asp Gln Pro Glu Ser  Arg Asn Val Ser Thr  Val His Arg 
    4190                 4195                 4200             


Asp Phe  Arg Leu Trp Leu Ile  Val Pro Ala Glu Ser  Ser Ala Ser 
    4205                 4210                 4215             


Leu Pro  Ala Val Leu Thr Gln  His Ser Met Pro Val  Phe Trp Asn 
    4220                 4225                 4230             


Gln Ser  Leu Glu Leu Gly His  Val Leu Ile Asp Ser  Val Glu Leu 
    4235                 4240                 4245             


Ala Gln  Gln Val Leu Tyr Met  Gln Pro Pro Thr Gln  Ala Leu Pro 
    4250                 4255                 4260             


Leu Leu  Leu Leu His Gly Leu  Leu Leu His Arg Gln  Leu Tyr Gly 
    4265                 4270                 4275             


Thr Arg  Leu Gln Ala His Arg  Gly Arg Trp Ser Gln  Val Thr Leu 
    4280                 4285                 4290             


Thr Gln  Val Leu Gln Thr Gln  Asp Gln Leu Trp Ala  Ser Leu Ser 
    4295                 4300                 4305             


Asn Pro  Arg Ala Ala Met Gln  Glu Leu Ala Ala Ser  Val Phe Tyr 
    4310                 4315                 4320             


Gly Gly  Pro Leu Gly Asp Thr  Glu Asp Arg Glu Ala  Leu Ile Ser 
    4325                 4330                 4335             


Leu Thr  Gln Ala Cys Leu Ser  Pro Ser Ser Gly Ser  Trp Val Gln 
    4340                 4345                 4350             


Pro His  Thr Pro Gln Ser Leu  Leu Ala Thr Leu Met  Pro Leu Pro 
    4355                 4360                 4365             


Glu Leu  Arg Glu Leu Asp Ala  Met Ala Glu Cys Lys  Ala Gln Met 
    4370                 4375                 4380             


His Leu  Leu Pro Ser Pro Pro  Glu Pro Arg Leu Cys  Gly Leu Ser 
    4385                 4390                 4395             


Glu Gly  Pro Gln Ala Trp Leu  Leu Arg Arg Gln Ser  Arg Ala Leu 
    4400                 4405                 4410             


Leu Ser  Ala Leu Gln Arg Ser  Ser Pro Val Trp Val  Pro Glu Ser 
    4415                 4420                 4425             


Arg Arg  Gly Ala Gln Leu Ala  Glu Arg Arg Leu Arg  Gln Arg Leu 
    4430                 4435                 4440             


Val Gln  Val Asn Arg Arg Leu  Glu Ser Leu Gln Asp  Leu Leu Thr 
    4445                 4450                 4455             


His Val  Ile Arg Gln Asp Glu  Ser Asp Ala Pro Trp  Ser Val Leu 
    4460                 4465                 4470             


Gly Pro  Asn Ala Arg Arg Pro  Leu Glu Gly Val Leu  Glu Thr Glu 
    4475                 4480                 4485             


Ala Leu  Glu Leu Ser Gln Leu  Val Gly Thr Leu Gln  Arg Asp Leu 
    4490                 4495                 4500             


Asp Cys  Leu Leu Gln Gln Leu  Lys Gly Ala Pro Pro  Cys Pro Ser 
    4505                 4510                 4515             


Arg Arg  Cys Ala Ala Val Ala  His Ala Leu Trp Thr  Gly Arg Leu 
    4520                 4525                 4530             


Pro Leu  Pro Trp Arg Pro His  Ala Pro Ala Gly Pro  Gln Pro Pro 
    4535                 4540                 4545             


Trp His  Trp Leu Arg Gln Leu  Ser Arg Arg Gly Gln  Leu Leu Val 
    4550                 4555                 4560             


Arg Tyr  Leu Gly Val Gly Ala  Asp Ala Ser Ser Asp  Val Pro Glu 
    4565                 4570                 4575             


Arg Val  Phe His Leu Ser Ala  Phe Arg His Pro Arg  Arg Leu Leu 
    4580                 4585                 4590             


Leu Ala  Leu Arg Gly Glu Ala  Ala Leu Asp Gln Asn  Val Pro Ser 
    4595                 4600                 4605             


Ser Asn  Phe Pro Gly Ser Arg  Gly Ser Val Ser Ser  Gln Leu Gln 
    4610                 4615                 4620             


Tyr Lys  Arg Leu Glu Met Asn  Ser Asn Pro Leu His  Phe Arg Val 
    4625                 4630                 4635             


Glu Asn  Gly Pro Asn Pro Thr  Val Pro Glu Arg Gly  Leu Leu Leu 
    4640                 4645                 4650             


Ile Gly  Leu Gln Val Leu His  Ala Glu Trp Asp Pro  Ile Ala Gly 
    4655                 4660                 4665             


Ala Leu  Gln Asp Ser Pro Ser  Ser Gln Pro Ser Pro  Leu Pro Pro 
    4670                 4675                 4680             


Val Ser  Ile Ser Thr Gln Ala  Pro Gly Thr Ser Asp  Leu Pro Ala 
    4685                 4690                 4695             


Pro Ala  Asp Leu Thr Val Tyr  Ser Cys Pro Val Tyr  Met Gly Gly 
    4700                 4705                 4710             


Pro Leu  Gly Thr Ala Lys Leu  Gln Ser Arg Asn Ile  Val Met His 
    4715                 4720                 4725             


Leu Pro  Leu Pro Thr Lys Leu  Thr Pro Asn Thr Cys  Val Gln Arg 
    4730                 4735                 4740             


Arg Val  His Val Cys Ser Pro  Pro Leu Ser 
    4745                 4750             


<210> 8592
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8592
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro 
    


<210> 8593
<211> 288
<212> PRT
<213> Homo sapiens

<400> 8593
Met Glu Arg Glu Pro Ser Ala Ser Glu Ala Ala Pro Ala Ala Ala Ala 
1               5                   10                  15      


Leu Phe Ala Trp Gly Ala Asn Ser Tyr Gly Gln Leu Gly Leu Gly His 
            20                  25                  30          


Lys Glu Asp Val Leu Leu Pro Gln Gln Leu Asn Asp Phe Cys Lys Pro 
        35                  40                  45              


Arg Ser Val Arg Arg Ile Thr Gly Gly Gly Gly His Ser Ala Val Val 
    50                  55                  60                  


Thr Asp Gly Gly Asp Leu Phe Val Cys Gly Leu Asn Lys Asp Gly Gln 
65                  70                  75                  80  


Leu Gly Leu Gly His Thr Glu Asp Ile Pro Tyr Phe Thr Pro Cys Lys 
                85                  90                  95      


Ser Leu Phe Gly Cys Pro Ile Gln Gln Val Ala Cys Gly Trp Asp Phe 
            100                 105                 110         


Thr Ile Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys Gly Ser Asn 
        115                 120                 125             


Ser Phe Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg Cys Val Val 
    130                 135                 140                 


Pro Gln Ala Ile Glu Leu His Lys Glu Lys Val Val Cys Ile Ala Ala 
145                 150                 155                 160 


Gly Leu Arg His Ala Val Ala Ala Thr Ala Ser Gly Ile Val Phe Gln 
                165                 170                 175     


Trp Gly Thr Gly Leu Ala Ser Cys Gly Arg Arg Leu Cys Pro Gly Gln 
            180                 185                 190         


Thr Leu Pro Leu Phe Phe Thr Ala Lys Glu Pro Ser Arg Val Thr Gly 
        195                 200                 205             


Leu Glu Asn Ser Lys Ala Met Cys Val Leu Ala Gly Ser Asp His Ser 
    210                 215                 220                 


Ala Ser Leu Thr Asp Ala Gly Glu Val Tyr Val Trp Gly Ser Asn Lys 
225                 230                 235                 240 


His Gly Gln Leu Ala Asn Glu Ala Ala Phe Leu Pro Val Pro Gln Lys 
                245                 250                 255     


Ile Glu Ala His Cys Phe Gln Asn Glu Lys Val Thr Ala Ile Trp Ser 
            260                 265                 270         


Gly Trp Thr His Leu Val Ala Gln Thr Gly Leu Leu Trp Leu Arg Ala 
        275                 280                 285             


<210> 8594
<211> 123
<212> PRT
<213> Homo sapiens

<400> 8594
Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly 
        115                 120             


<210> 8595
<211> 107
<212> PRT
<213> Homo sapiens

<400> 8595
Met Leu Arg Leu Tyr Pro Gly Pro Met Val Thr Glu Ala Glu Gly Lys 
1               5                   10                  15      


Gly Gly Pro Glu Met Ala Ser Leu Ser Ser Ser Val Val Pro Val Ser 
            20                  25                  30          


Phe Ile Ser Thr Leu Arg Glu Ser Val Leu Asp Pro Gly Val Gly Gly 
        35                  40                  45              


Glu Gly Ala Ser Asp Lys Gln Arg Ser Lys Leu Ser Leu Ser His Ser 
    50                  55                  60                  


Met Ile Pro Ala Ala Lys Ile His Thr Glu Leu Cys Leu Pro Ala Phe 
65                  70                  75                  80  


Phe Ser Pro Ala Gly Thr Gln Arg Arg Phe Gln Gln Pro Gln His His 
                85                  90                  95      


Leu Thr Leu Ser Ile Ile His Thr Ala Ala Arg 
            100                 105         


<210> 8596
<211> 550
<212> PRT
<213> Homo sapiens

<400> 8596
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Cys Val Phe Thr Val Thr Lys Ala His 
            260                 265                 270         


Phe Gln Thr Pro Thr Pro Val Val Thr Asp Thr Leu Arg Val Pro Met 
        275                 280                 285             


Ala Gly Leu Ala Phe Ser His Gln Leu Ser Ser Ser Arg Leu Ser Tyr 
    290                 295                 300                 


Gln Pro Ala Ala Leu Gly Val Gly Ser Ala Asp Leu Ala Tyr Pro Val 
305                 310                 315                 320 


Val Phe Ala Ala Gly Leu Asn Ala Thr His Pro His Gln Leu Met Val 
                325                 330                 335     


Pro Gly Lys Glu Gly Gly Val Pro Leu Ala Pro Asn Gln Pro Val His 
            340                 345                 350         


Gly Thr Gln Ala Asp Gln Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp 
        355                 360                 365             


Arg Thr His Cys Ala Ala Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr 
    370                 375                 380                 


Val Ser Asn Ser Ser Glu Gly Arg Ala Ser Pro His Asp Val Leu Glu 
385                 390                 395                 400 


Thr Ile Phe Val Arg Lys Val Gly Ala Phe Val Asn Lys Pro Ile Asn 
                405                 410                 415     


Gln Val Thr Leu Thr Ser Leu Asp Ile Pro Phe Ala Met Phe Ala Pro 
            420                 425                 430         


Lys Asn Leu Glu Leu Glu Asp Thr Asp Pro Met Val Asn Pro Pro Asp 
        435                 440                 445             


Ser Pro Glu Thr Glu Ser Pro Leu Gln Gly Ser Leu His Ser Asp Gly 
    450                 455                 460                 


Ser Ser Gly Gly Ser Ser Gly Asn Thr His Asp Asp Phe Val Met Ile 
465                 470                 475                 480 


Asp Phe Lys Pro Ala Phe Ser Lys Asp Asp Ile Leu Pro Met Asp Leu 
                485                 490                 495     


Gly Thr Phe Tyr Arg Glu Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu 
            500                 505                 510         


Ser Ile Asp Ile Gly Ala Gln Ser Met Ala Glu Asp Leu Asp Ser Leu 
        515                 520                 525             


Pro Glu Lys Leu Ala Val His Glu Lys Asn Val Arg Glu Phe Asp Ala 
    530                 535                 540                 


Phe Val Glu Thr Leu Gln 
545                 550 


<210> 8597
<211> 1367
<212> PRT
<213> Homo sapiens

<400> 8597
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys 
    50                  55                  60                  


Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Pro Thr Cys Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr 
                85                  90                  95      


Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr 
            100                 105                 110         


Glu Asn Gly Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile 
        115                 120                 125             


Thr Ser Arg Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn 
    130                 135                 140                 


Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg 
145                 150                 155                 160 


Val Leu Ile Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu 
                165                 170                 175     


Phe His Asn Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser 
            180                 185                 190         


Glu Pro Val Gln Leu Leu Arg Tyr Ser Pro Thr Leu Ala Ser Glu Thr 
        195                 200                 205             


Ser Pro Val Pro Glu Ala Arg Arg Gly Ser Ser Ala Asp Ser Leu Pro 
    210                 215                 220                 


Ser His Arg Pro Ser Pro Thr Asp Ser Arg Leu Arg Ser Ser Lys Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Ser Glu Ser Ser Trp Tyr Asp Ser Pro Trp Gly Asn 
                245                 250                 255     


Ala Gly Glu Leu Ser Glu Ala Glu Gly Ser Phe Leu Ala Pro Gly Met 
            260                 265                 270         


Pro Asp Pro Ser Leu His Ala Ser Phe Pro Pro Gly Asp Ala Lys Lys 
        275                 280                 285             


Pro Phe Asn Gln Ser Ser Ser Leu Ser Ser Leu Arg Glu Leu Tyr Lys 
    290                 295                 300                 


Asp Ala Asn Leu Gly Ser Leu Ser Pro Ser Gly Ile Arg Leu Ser Asp 
305                 310                 315                 320 


Glu Tyr Met Gly Thr His Ala Ser Leu Ser Asn Arg Val Ser Phe Ala 
                325                 330                 335     


Ser Asp Ile Asp Val Pro Ser Arg Val Ala His Gly Asp Pro Ile Gln 
            340                 345                 350         


Tyr Ser Ser Phe Thr Leu Pro Cys Arg Lys Pro Lys Ala Phe Val Glu 
        355                 360                 365             


Asp Thr Ala Lys Lys Asp Ser Leu Lys Ala Arg Met Arg Arg Ile Ser 
    370                 375                 380                 


Asp Trp Thr Gly Ser Leu Ser Arg Lys Lys Arg Lys Leu Gln Glu Pro 
385                 390                 395                 400 


Arg Ser Lys Glu Gly Ser Asp Tyr Phe Asp Ser Arg Ser Asp Gly Leu 
                405                 410                 415     


Asn Thr Asp Val Gln Gly Ser Ser Gln Ala Ser Ala Phe Leu Trp Ser 
            420                 425                 430         


Gly Gly Ser Thr Gln Ile Leu Ser Gln Arg Ser Glu Ser Thr His Ala 
        435                 440                 445             


Ile Gly Ser Asp Pro Leu Arg Gln Asn Ile Tyr Glu Asn Phe Met Arg 
    450                 455                 460                 


Glu Leu Glu Met Ser Arg Thr Asn Thr Glu Asn Ile Glu Thr Ser Thr 
465                 470                 475                 480 


Glu Thr Ala Glu Ser Ser Ser Glu Ser Leu Ser Ser Leu Glu Gln Leu 
                485                 490                 495     


Asp Leu Leu Phe Glu Lys Glu Gln Gly Val Val Arg Lys Ala Gly Trp 
            500                 505                 510         


Leu Phe Phe Lys Pro Leu Val Thr Val Gln Lys Glu Arg Lys Leu Glu 
        515                 520                 525             


Leu Val Ala Arg Arg Lys Trp Lys Gln Tyr Trp Val Thr Leu Lys Gly 
    530                 535                 540                 


Cys Thr Leu Leu Phe Tyr Glu Thr Tyr Gly Lys Asn Ser Met Asp Gln 
545                 550                 555                 560 


Ser Ser Ala Pro Arg Cys Ala Leu Phe Ala Glu Asp Ser Ile Val Gln 
                565                 570                 575     


Ser Val Pro Glu His Pro Lys Lys Glu Asn Val Phe Cys Leu Ser Asn 
            580                 585                 590         


Ser Phe Gly Asp Val Tyr Leu Phe Gln Ala Thr Ser Gln Thr Asp Leu 
        595                 600                 605             


Glu Asn Trp Val Thr Ala Val His Ser Ala Cys Ala Ser Leu Phe Ala 
    610                 615                 620                 


Lys Lys His Gly Lys Glu Asp Thr Leu Arg Leu Leu Lys Asn Gln Thr 
625                 630                 635                 640 


Lys Asn Leu Leu Gln Lys Ile Asp Met Asp Ser Lys Met Lys Lys Met 
                645                 650                 655     


Ala Glu Leu Gln Leu Ser Val Val Ser Asp Pro Lys Asn Arg Lys Ala 
            660                 665                 670         


Ile Glu Asn Gln Ile Gln Gln Trp Glu Gln Asn Leu Glu Lys Phe His 
        675                 680                 685             


Met Asp Leu Phe Arg Met Arg Cys Tyr Leu Ala Ser Leu Gln Gly Gly 
    690                 695                 700                 


Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala Ala Ala Ser Arg Pro Ser 
705                 710                 715                 720 


Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu Ser Val Ser Ser Phe His 
                725                 730                 735     


Ala Leu Val Cys Ser Arg Asp Asp Ser Ala Leu Arg Lys Arg Thr Leu 
            740                 745                 750         


Ser Leu Thr Gln Arg Gly Arg Asn Lys Lys Gly Ile Phe Ser Ser Leu 
        755                 760                 765             


Lys Gly Leu Asp Thr Leu Ala Arg Lys Gly Lys Glu Lys Arg Pro Ser 
    770                 775                 780                 


Ile Thr Gln Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp 
785                 790                 795                 800 


Gly Val Pro Arg Asp Asn Ala Trp Glu Ile Gln Thr Tyr Val His Phe 
                805                 810                 815     


Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val 
            820                 825                 830         


Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser 
        835                 840                 845             


His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr 
    850                 855                 860                 


Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu 
865                 870                 875                 880 


Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr 
                885                 890                 895     


Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu 
            900                 905                 910         


Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly 
        915                 920                 925             


Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu 
    930                 935                 940                 


Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu 
945                 950                 955                 960 


Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp 
                965                 970                 975     


Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser 
            980                 985                 990         


Arg Asp Gln Lys Ser Leu Leu Pro  Pro Pro Asn Gln Ser  Gln Leu Leu 
        995                 1000                 1005             


Glu Glu  Phe Leu Asp Asn Phe  Lys Lys Asn Thr Ala  Asn Asp Phe 
    1010                 1015                 1020             


Ser Asn  Val Pro Asp Ile Thr  Thr Gly Leu Lys Arg  Ser Gln Thr 
    1025                 1030                 1035             


Asp Gly  Thr Leu Asp Gln Val  Ser His Arg Glu Lys  Met Glu Gln 
    1040                 1045                 1050             


Thr Phe  Arg Ser Ala Glu Gln  Ile Thr Ala Leu Cys  Arg Ser Phe 
    1055                 1060                 1065             


Asn Asp  Ser Gln Ala Asn Gly  Met Glu Gly Pro Arg  Glu Asn Gln 
    1070                 1075                 1080             


Asp Pro  Pro Pro Arg Ser Leu  Ala Arg His Leu Ser  Asp Ala Asp 
    1085                 1090                 1095             


Arg Leu  Arg Lys Val Ile Gln  Glu Leu Val Asp Thr  Glu Lys Ser 
    1100                 1105                 1110             


Tyr Val  Lys Asp Leu Ser Cys  Leu Phe Glu Leu Tyr  Leu Glu Pro 
    1115                 1120                 1125             


Leu Gln  Asn Glu Thr Phe Leu  Thr Gln Asp Glu Met  Glu Ser Leu 
    1130                 1135                 1140             


Phe Gly  Ser Leu Pro Glu Met  Leu Glu Phe Gln Lys  Val Phe Leu 
    1145                 1150                 1155             


Glu Thr  Leu Glu Asp Gly Ile  Ser Ala Ser Ser Asp  Phe Asn Thr 
    1160                 1165                 1170             


Leu Glu  Thr Pro Ser Gln Phe  Arg Lys Leu Leu Phe  Ser Leu Gly 
    1175                 1180                 1185             


Gly Ser  Phe Leu Tyr Tyr Ala  Asp His Phe Lys Leu  Tyr Ser Gly 
    1190                 1195                 1200             


Phe Cys  Ala Asn His Ile Lys  Val Gln Lys Val Leu  Glu Arg Ala 
    1205                 1210                 1215             


Lys Thr  Asp Lys Ala Phe Lys  Ala Phe Leu Asp Ala  Arg Asn Pro 
    1220                 1225                 1230             


Thr Lys  Gln His Ser Ser Thr  Leu Glu Ser Tyr Leu  Ile Lys Pro 
    1235                 1240                 1245             


Val Gln  Arg Val Leu Lys Tyr  Pro Leu Leu Leu Lys  Glu Leu Val 
    1250                 1255                 1260             


Ser Leu  Thr Asp Gln Glu Ser  Glu Glu His Tyr His  Leu Thr Glu 
    1265                 1270                 1275             


Ala Leu  Lys Ala Met Glu Lys  Val Ala Ser His Ile  Asn Glu Met 
    1280                 1285                 1290             


Gln Lys  Ile Tyr Glu Asp Tyr  Gly Thr Val Phe Asp  Gln Leu Val 
    1295                 1300                 1305             


Ala Glu  Gln Ser Gly Thr Glu  Lys Glu Val Thr Glu  Leu Ser Met 
    1310                 1315                 1320             


Gly Glu  Leu Leu Met His Ser  Thr Val Ser Trp Leu  Asn Pro Phe 
    1325                 1330                 1335             


Leu Ser  Leu Gly Lys Ala Arg  Lys Asp Leu Glu Leu  Thr Val Phe 
    1340                 1345                 1350             


Val Phe  Lys Arg Ala Val Ile  Leu Val Tyr Lys Glu  Asn Cys 
    1355                 1360                 1365         


<210> 8598
<211> 14
<212> PRT
<213> Homo sapiens

<400> 8598
Met Asn Gly Thr Leu Asp His Pro Asp Gln Pro Asp Leu Asp 
1               5                   10                  


<210> 8599
<211> 172
<212> PRT
<213> Homo sapiens

<400> 8599
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser Glu 
    130                 135                 140                 


Ala Asp Val Arg Val Leu Glu Glu Gln Ala Gln Asn Leu Gly Leu Glu 
145                 150                 155                 160 


Gly Thr Leu Val Ser Leu Ala Arg Val Pro Gln Ala 
                165                 170         


<210> 8600
<211> 8
<212> PRT
<213> Homo sapiens

<400> 8600
Met Phe Trp Lys Phe Asp Leu His 
1               5               


<210> 8601
<211> 136
<212> PRT
<213> Homo sapiens

<400> 8601
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro Arg Pro Asp Arg Ala Leu Val 
    130                 135     


<210> 8602
<211> 1947
<212> PRT
<213> Homo sapiens

<400> 8602
Gly Arg Pro Ile Asp Pro Arg Glu Gly Pro Gly Arg Pro Pro Leu Asp 
1               5                   10                  15      


Gly Arg Asp His Phe Gly Arg Pro Pro Val Asp Ile Arg Glu Asn Leu 
            20                  25                  30          


Val Arg Pro Gly Ile Asp His Leu Gly Arg Arg Asp His Phe Gly Phe 
        35                  40                  45              


Asn Pro Glu Lys Pro Trp Gly His Arg Gly Asp Phe Asp Glu Arg Glu 
    50                  55                  60                  


His Arg Val Leu Pro Val Tyr Gly Gly Pro Lys Gly Leu His Glu Glu 
65                  70                  75                  80  


Arg Gly Arg Phe Arg Ser Gly Asn Tyr Arg Phe Asp Pro Arg Ser Gly 
                85                  90                  95      


Pro Trp Asn Arg Gly Phe Gly Gln Glu Val His Arg Asp Phe Asp Asp 
            100                 105                 110         


Arg Arg Arg Pro Trp Glu Arg Gln Arg Asp Arg Asp Asp Arg Asp Phe 
        115                 120                 125             


Asp Phe Cys Arg Glu Met Asn Gly Asn Arg Leu Gly Arg Asp Arg Ile 
    130                 135                 140                 


Gln Asn Thr Trp Val Pro Pro Pro His Ala Arg Val Phe Asp Tyr Phe 
145                 150                 155                 160 


Glu Gly Ala Thr Ser Gln Arg Lys Gly Asp Asn Val Pro Gln Val Asn 
                165                 170                 175     


Gly Glu Asn Thr Glu Arg His Ala Gln Pro Pro Pro Ile Pro Val Gln 
            180                 185                 190         


Asn Asp Pro Glu Leu Tyr Glu Lys Leu Thr Ser Ser Asn Glu Ile Asn 
        195                 200                 205             


Lys Glu Lys Ser Asp Thr Val Ala Asp Ile Glu Ser Glu Pro Val Val 
    210                 215                 220                 


Glu Ser Thr Glu Thr Glu Gly Thr Pro Leu Thr Ser Leu Thr Ala Glu 
225                 230                 235                 240 


Thr Arg Arg Gln Val Lys Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu 
                245                 250                 255     


Gln Gly Ser Lys Asn His Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile 
            260                 265                 270         


Pro Cys Ser Leu Lys Ile Arg Gly Ile His Ala Lys Glu Glu Lys Ser 
        275                 280                 285             


Leu His Gly Trp Gly His Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg 
    290                 295                 300                 


Ser Leu Ala Arg Ser Cys Leu Ser His Phe Lys Ser Asn Gln Pro Tyr 
305                 310                 315                 320 


Ala Ser Arg Leu Gly Gly Pro Thr Cys Lys Val Ser Arg Gly Val Ala 
                325                 330                 335     


Tyr Ser Thr His Arg Thr Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile 
            340                 345                 350         


Ser Ala Ala Phe Ser Thr Glu Asn Gly Phe His Ser Val Gly His Glu 
        355                 360                 365             


Leu Ala Asp Asn His Ile Thr Ser Arg Asp Cys Asn Gly His Leu Leu 
    370                 375                 380                 


Asn Cys Tyr Gly Arg Asn Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu 
385                 390                 395                 400 


Asp Arg Lys Ser Pro Arg Val Leu Ile Lys Thr Leu Gly Lys Leu Asp 
                405                 410                 415     


Gly Cys Leu Arg Val Glu Phe His Asn Gly Gly Asn Pro Ser Lys Val 
            420                 425                 430         


Pro Ala Glu Asp Cys Ser Glu Pro Val Gln Leu Leu Arg Tyr Ser Pro 
        435                 440                 445             


Thr Leu Ala Ser Glu Thr Ser Pro Val Pro Glu Ala Arg Arg Gly Ser 
    450                 455                 460                 


Ser Ala Asp Ser Leu Pro Ser His Arg Pro Ser Pro Thr Asp Ser Arg 
465                 470                 475                 480 


Leu Arg Ser Ser Lys Gly Ser Ser Leu Ser Ser Glu Ser Ser Trp Tyr 
                485                 490                 495     


Asp Ser Pro Trp Gly Asn Ala Gly Glu Leu Ser Glu Ala Glu Gly Ser 
            500                 505                 510         


Phe Leu Ala Pro Gly Met Pro Asp Pro Ser Leu His Ala Ser Phe Pro 
        515                 520                 525             


Pro Gly Asp Ala Lys Lys Pro Phe Asn Gln Ser Ser Ser Leu Ser Ser 
    530                 535                 540                 


Leu Arg Glu Leu Tyr Lys Asp Ala Asn Leu Gly Ser Leu Ser Pro Ser 
545                 550                 555                 560 


Gly Ile Arg Leu Ser Asp Glu Tyr Met Gly Thr His Ala Ser Leu Ser 
                565                 570                 575     


Asn Arg Val Ser Phe Ala Ser Asp Ile Asp Val Pro Ser Arg Val Ala 
            580                 585                 590         


His Gly Asp Pro Ile Gln Tyr Ser Ser Phe Thr Leu Pro Cys Arg Lys 
        595                 600                 605             


Pro Lys Ala Phe Val Glu Asp Thr Ala Lys Lys Asp Ser Leu Lys Ala 
    610                 615                 620                 


Arg Met Arg Arg Ile Ser Asp Trp Thr Gly Ser Leu Ser Arg Lys Lys 
625                 630                 635                 640 


Arg Lys Leu Gln Glu Pro Arg Ser Lys Glu Gly Ser Asp Tyr Phe Asp 
                645                 650                 655     


Ser Arg Ser Asp Gly Leu Asn Thr Asp Val Gln Gly Ser Ser Gln Ala 
            660                 665                 670         


Ser Ala Phe Leu Trp Ser Gly Gly Ser Thr Gln Ile Leu Ser Gln Arg 
        675                 680                 685             


Ser Glu Ser Thr His Ala Ile Gly Ser Asp Pro Leu Arg Gln Asn Ile 
    690                 695                 700                 


Tyr Glu Asn Phe Met Arg Glu Leu Glu Met Ser Arg Thr Asn Thr Glu 
705                 710                 715                 720 


Asn Ile Glu Thr Ser Thr Glu Thr Ala Glu Ser Ser Ser Glu Ser Leu 
                725                 730                 735     


Ser Ser Leu Glu Gln Leu Asp Leu Leu Phe Glu Lys Glu Gln Gly Val 
            740                 745                 750         


Val Arg Lys Ala Gly Trp Leu Phe Phe Lys Pro Leu Val Thr Val Gln 
        755                 760                 765             


Lys Glu Arg Lys Leu Glu Leu Val Ala Arg Arg Lys Trp Lys Gln Tyr 
    770                 775                 780                 


Trp Val Thr Leu Lys Gly Cys Thr Leu Leu Phe Tyr Glu Thr Tyr Gly 
785                 790                 795                 800 


Lys Asn Ser Met Asp Gln Ser Ser Ala Pro Arg Cys Ala Leu Phe Ala 
                805                 810                 815     


Glu Asp Ser Ile Val Gln Ser Val Pro Glu His Pro Lys Lys Glu Asn 
            820                 825                 830         


Val Phe Cys Leu Ser Asn Ser Phe Gly Asp Val Tyr Leu Phe Gln Ala 
        835                 840                 845             


Thr Ser Gln Thr Asp Leu Glu Asn Trp Val Thr Ala Val His Ser Ala 
    850                 855                 860                 


Cys Ala Ser Leu Phe Ala Lys Lys His Gly Lys Glu Asp Thr Leu Arg 
865                 870                 875                 880 


Leu Leu Lys Asn Gln Thr Lys Asn Leu Leu Gln Lys Ile Asp Met Asp 
                885                 890                 895     


Ser Lys Met Lys Lys Met Ala Glu Leu Gln Leu Ser Val Val Ser Asp 
            900                 905                 910         


Pro Lys Asn Arg Lys Ala Ile Glu Asn Gln Ile Gln Gln Trp Glu Gln 
        915                 920                 925             


Asn Leu Glu Lys Phe His Met Asp Leu Phe Arg Met Arg Cys Tyr Leu 
    930                 935                 940                 


Ala Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala 
945                 950                 955                 960 


Ala Ala Ser Arg Pro Ser Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu 
                965                 970                 975     


Ser Val Ser Ser Phe His Ala Leu Val Cys Ser Arg Asp Asp Ser Ala 
            980                 985                 990         


Leu Arg Lys Arg Thr Leu Ser Leu  Thr Gln Arg Gly Arg  Asn Lys Lys 
        995                 1000                 1005             


Gly Ile  Phe Ser Ser Leu Lys  Gly Leu Asp Thr Leu  Ala Arg Lys 
    1010                 1015                 1020             


Gly Lys  Glu Lys Arg Pro Ser  Ile Thr Gln Val Asp  Glu Leu Leu 
    1025                 1030                 1035             


His Ile  Tyr Gly Ser Thr Val  Asp Gly Val Pro Arg  Asp Asn Ala 
    1040                 1045                 1050             


Trp Glu  Ile Gln Thr Tyr Val  His Phe Gln Asp Asn  His Gly Val 
    1055                 1060                 1065             


Thr Val  Gly Ile Lys Pro Glu  His Arg Val Glu Asp  Ile Leu Thr 
    1070                 1075                 1080             


Leu Ala  Cys Lys Met Arg Gln  Leu Glu Pro Ser His  Tyr Gly Leu 
    1085                 1090                 1095             


Gln Leu  Arg Lys Leu Val Asp  Asp Asn Val Glu Tyr  Cys Ile Pro 
    1100                 1105                 1110             


Ala Pro  Tyr Glu Tyr Met Gln  Gln Gln Val Tyr Asp  Glu Ile Glu 
    1115                 1120                 1125             


Val Phe  Pro Leu Asn Val Tyr  Asp Val Gln Leu Thr  Lys Thr Gly 
    1130                 1135                 1140             


Ser Val  Cys Asp Phe Gly Phe  Ala Val Thr Ala Gln  Val Asp Glu 
    1145                 1150                 1155             


Arg Gln  His Leu Ser Arg Ile  Phe Ile Ser Asp Val  Leu Pro Asp 
    1160                 1165                 1170             


Gly Leu  Ala Tyr Gly Glu Gly  Leu Arg Lys Gly Asn  Glu Ile Met 
    1175                 1180                 1185             


Thr Leu  Asn Gly Glu Ala Val  Ser Asp Leu Asp Leu  Lys Gln Met 
    1190                 1195                 1200             


Glu Ala  Leu Phe Ser Glu Lys  Ser Val Gly Leu Thr  Leu Ile Ala 
    1205                 1210                 1215             


Arg Pro  Pro Asp Thr Lys Ala  Thr Leu Cys Thr Ser  Trp Ser Asp 
    1220                 1225                 1230             


Ser Asp  Leu Phe Ser Arg Asp  Gln Lys Ser Leu Leu  Pro Pro Pro 
    1235                 1240                 1245             


Asn Gln  Ser Gln Leu Leu Glu  Glu Phe Leu Asp Asn  Phe Lys Lys 
    1250                 1255                 1260             


Asn Thr  Ala Asn Asp Phe Ser  Asn Val Pro Asp Ile  Thr Thr Gly 
    1265                 1270                 1275             


Leu Lys  Arg Ser Gln Thr Asp  Gly Thr Leu Asp Gln  Val Ser His 
    1280                 1285                 1290             


Arg Glu  Lys Met Glu Gln Thr  Phe Arg Ser Ala Glu  Gln Ile Thr 
    1295                 1300                 1305             


Ala Leu  Cys Arg Ser Phe Asn  Asp Ser Gln Ala Asn  Gly Met Glu 
    1310                 1315                 1320             


Gly Pro  Arg Glu Asn Gln Asp  Pro Pro Pro Arg Ser  Leu Ala Arg 
    1325                 1330                 1335             


His Leu  Ser Asp Ala Asp Arg  Leu Arg Lys Val Ile  Gln Glu Leu 
    1340                 1345                 1350             


Val Asp  Thr Glu Lys Ser Tyr  Val Lys Asp Leu Ser  Cys Leu Phe 
    1355                 1360                 1365             


Glu Leu  Tyr Leu Glu Pro Leu  Gln Asn Glu Thr Phe  Leu Thr Gln 
    1370                 1375                 1380             


Asp Glu  Met Glu Ser Leu Phe  Gly Ser Leu Pro Glu  Met Leu Glu 
    1385                 1390                 1395             


Phe Gln  Lys Val Phe Leu Glu  Thr Leu Glu Asp Gly  Ile Ser Ala 
    1400                 1405                 1410             


Ser Ser  Asp Phe Asn Thr Leu  Glu Thr Pro Ser Gln  Phe Arg Lys 
    1415                 1420                 1425             


Leu Leu  Phe Ser Leu Gly Gly  Ser Phe Leu Tyr Tyr  Ala Asp His 
    1430                 1435                 1440             


Phe Lys  Leu Tyr Ser Gly Phe  Cys Ala Asn His Ile  Lys Val Gln 
    1445                 1450                 1455             


Lys Val  Leu Glu Arg Ala Lys  Thr Asp Lys Ala Phe  Lys Ala Phe 
    1460                 1465                 1470             


Leu Asp  Ala Arg Asn Pro Thr  Lys Gln His Ser Ser  Thr Leu Glu 
    1475                 1480                 1485             


Ser Tyr  Leu Ile Lys Pro Val  Gln Arg Val Leu Lys  Tyr Pro Leu 
    1490                 1495                 1500             


Leu Leu  Lys Glu Leu Val Ser  Leu Thr Asp Gln Glu  Ser Glu Glu 
    1505                 1510                 1515             


His Tyr  His Leu Thr Glu Ala  Leu Lys Ala Met Glu  Lys Val Ala 
    1520                 1525                 1530             


Ser His  Ile Asn Glu Met Gln  Lys Ile Tyr Glu Asp  Tyr Gly Thr 
    1535                 1540                 1545             


Val Phe  Asp Gln Leu Val Ala  Glu Gln Ser Gly Thr  Glu Lys Glu 
    1550                 1555                 1560             


Val Thr  Glu Leu Ser Met Gly  Glu Leu Leu Met His  Ser Thr Val 
    1565                 1570                 1575             


Ser Trp  Leu Asn Pro Phe Leu  Ser Leu Gly Lys Ala  Arg Lys Asp 
    1580                 1585                 1590             


Leu Glu  Leu Thr Val Phe Val  Phe Lys Arg Ala Val  Ile Leu Val 
    1595                 1600                 1605             


Tyr Lys  Glu Asn Cys Lys Leu  Lys Lys Lys Leu Pro  Ser Asn Ser 
    1610                 1615                 1620             


Arg Pro  Ala His Asn Ser Thr  Asp Leu Asp Pro Phe  Lys Phe Arg 
    1625                 1630                 1635             


Trp Leu  Ile Pro Ile Ser Ala  Leu Gln Val Arg Leu  Gly Asn Pro 
    1640                 1645                 1650             


Ala Gly  Thr Glu Asn Asn Ser  Ile Trp Glu Leu Ile  His Thr Lys 
    1655                 1660                 1665             


Ser Glu  Ile Glu Gly Arg Pro  Glu Thr Ile Phe Gln  Leu Cys Cys 
    1670                 1675                 1680             


Ser Asp  Ser Glu Ser Lys Thr  Asn Ile Val Lys Val  Ile Arg Ser 
    1685                 1690                 1695             


Ile Leu  Arg Glu Asn Phe Arg  Arg His Ile Lys Cys  Glu Leu Pro 
    1700                 1705                 1710             


Leu Glu  Lys Thr Cys Lys Asp  Arg Leu Val Pro Leu  Lys Asn Arg 
    1715                 1720                 1725             


Val Pro  Val Ser Ala Lys Leu  Ala Ser Ser Arg Ser  Leu Lys Val 
    1730                 1735                 1740             


Leu Lys  Asn Ser Ser Ser Asn  Glu Trp Thr Gly Glu  Thr Gly Lys 
    1745                 1750                 1755             


Gly Thr  Leu Leu Asp Ser Asp  Glu Gly Ser Leu Ser  Ser Gly Thr 
    1760                 1765                 1770             


Gln Ser  Ser Gly Cys Pro Thr  Ala Glu Gly Arg Gln  Asp Ser Lys 
    1775                 1780                 1785             


Ser Thr  Ser Pro Gly Lys Tyr  Pro His Pro Gly Leu  Ala Asp Phe 
    1790                 1795                 1800             


Ala Asp  Asn Leu Ile Lys Glu  Ser Asp Ile Leu Ser  Asp Glu Asp 
    1805                 1810                 1815             


Asp Asp  His Arg Gln Thr Val  Lys Gln Gly Ser Pro  Thr Lys Asp 
    1820                 1825                 1830             


Ile Glu  Ile Gln Phe Gln Arg  Leu Arg Ile Ser Glu  Asp Pro Asp 
    1835                 1840                 1845             


Val His  Pro Glu Ala Glu Gln  Gln Pro Gly Pro Glu  Ser Gly Glu 
    1850                 1855                 1860             


Gly Gln  Lys Gly Gly Glu Gln  Pro Lys Leu Val Arg  Gly His Phe 
    1865                 1870                 1875             


Cys Pro  Ile Lys Arg Lys Ala  Asn Ser Thr Lys Arg  Asp Arg Gly 
    1880                 1885                 1890             


Thr Leu  Leu Lys Ala Gln Ile  Arg His Gln Ser Leu  Asp Ser Gln 
    1895                 1900                 1905             


Ser Glu  Asn Ala Thr Ile Asp  Leu Asn Ser Val Leu  Glu Arg Glu 
    1910                 1915                 1920             


Phe Ser  Val Gln Ser Leu Thr  Ser Val Val Ser Glu  Glu Cys Phe 
    1925                 1930                 1935             


Tyr Glu  Thr Glu Ser His Gly  Lys Ser 
    1940                 1945         


<210> 8603
<211> 97
<212> PRT
<213> Homo sapiens

<400> 8603
Met Glu Ala Ala Asp Ala Ser Arg Ser Asn Gly Ser Ser Pro Glu Ala 
1               5                   10                  15      


Arg Asp Ala Arg Ser Pro Ser Gly Pro Ser Gly Ser Leu Glu Asn Gly 
            20                  25                  30          


Thr Lys Ala Asp Gly Lys Asp Ala Lys Thr Thr Asn Gly His Gly Gly 
        35                  40                  45              


Glu Ala Ala Glu Gly Lys Ser Leu Gly Ser Ala Leu Lys Pro Gly Glu 
    50                  55                  60                  


Gly Arg Ser Ala Leu Phe Ala Gly Asn Glu Trp Arg Arg Pro Ile Ile 
65                  70                  75                  80  


Gln Phe Val Glu Ser Gly Asp Asp Lys Asn Ser Asn Tyr Phe Ser Met 
                85                  90                  95      


Asp 
    


<210> 8604
<211> 38
<212> PRT
<213> Homo sapiens

<400> 8604
Met Glu Ala Ala Asp Ala Ser Arg Ser Asn Gly Ser Ser Pro Glu Ala 
1               5                   10                  15      


Arg Asp Ala Arg Ser Pro Ser Gly Pro Ser Gly Ser Leu Glu Asn Gly 
            20                  25                  30          


Thr Lys Ala Asp Gly Lys 
        35              


<210> 8605
<211> 484
<212> PRT
<213> Homo sapiens

<400> 8605
Met Ala Ile Gly Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys 
1               5                   10                  15      


Thr Gln Arg Leu Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro 
            20                  25                  30          


Ala Arg Val Trp Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg 
        35                  40                  45              


Val Pro His Thr Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro 
    50                  55                  60                  


Tyr Leu Ile Tyr Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr 
65                  70                  75                  80  


Ser Val Pro Ala Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser 
                85                  90                  95      


Val Glu Asn Leu Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly 
            100                 105                 110         


Ser Phe Ser Thr Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser 
        115                 120                 125             


Val Asp Asp Ile Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr 
    130                 135                 140                 


Asn Ser Cys Asp Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser 
145                 150                 155                 160 


Gln Glu Ser Lys Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg 
                165                 170                 175     


Arg Leu Ser Glu Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp 
            180                 185                 190         


Pro Glu Asp Pro Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys 
        195                 200                 205             


Val Arg Arg Ile Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp 
    210                 215                 220                 


Arg Leu Leu Ser Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu 
225                 230                 235                 240 


Leu Leu Ala Phe Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln 
                245                 250                 255     


Glu Arg Val Pro Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser 
            260                 265                 270         


Ala Asp Ser Gly Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His 
        275                 280                 285             


Gln Val Lys Lys Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln 
    290                 295                 300                 


Glu His Gly Ser Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn 
305                 310                 315                 320 


Phe Val Gln Ser Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln 
                325                 330                 335     


Val Lys Asp Arg His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His 
            340                 345                 350         


Ile Ile His Ile Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn 
        355                 360                 365             


Leu Gly Phe Glu Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp 
    370                 375                 380                 


Val Met Gly Gly Leu Asp Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu 
385                 390                 395                 400 


Met Leu Gln Gly Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val 
                405                 410                 415     


Gln Ile Val Glu Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His 
            420                 425                 430         


Gly Ser Ser Thr Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met 
        435                 440                 445             


Thr Glu Glu Gln Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser 
    450                 455                 460                 


Met Arg Ser Ile Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr 
465                 470                 475                 480 


Asn Gly Ile Met 
                


<210> 8606
<211> 75
<212> PRT
<213> Homo sapiens

<400> 8606
Met Ala Ile Pro Ile Thr Val Leu Asp Cys Asp Leu Leu Leu Tyr Gly 
1               5                   10                  15      


Arg Gly His Arg Thr Leu Asp Arg Phe Lys Leu Asp Asp Val Thr Asp 
            20                  25                  30          


Glu Tyr Leu Met Ser Met Tyr Gly Phe Pro Arg Gln Phe Ile Tyr Tyr 
        35                  40                  45              


Leu Val Glu Leu Leu Gly Ala Asn Leu Ser Arg Pro Thr Gln Arg Ser 
    50                  55                  60                  


Arg Ala Ile Ser Pro Glu Thr Gln Val Leu Ala 
65                  70                  75  


<210> 8607
<211> 917
<212> PRT
<213> Homo sapiens

<400> 8607
Met Asp Gly Ala Ala Gly Pro Gly Asp Gly Pro Ala Arg Glu Ala Leu 
1               5                   10                  15      


Gln Ser Leu Ser Gln Arg Leu Arg Val Gln Glu Gln Glu Met Glu Leu 
            20                  25                  30          


Val Lys Ala Ala Leu Ala Glu Ala Leu Arg Leu Leu Arg Leu Gln Val 
        35                  40                  45              


Pro Pro Ser Ser Leu Gln Gly Ser Gly Thr Pro Ala Pro Pro Gly Asp 
    50                  55                  60                  


Ser Leu Ala Ala Pro Pro Gly Leu Pro Pro Thr Cys Thr Pro Ser Leu 
65                  70                  75                  80  


Val Ser Arg Gly Thr Gln Thr Glu Thr Glu Val Glu Leu Lys Ser Ser 
                85                  90                  95      


Pro Gly Pro Pro Gly Leu Ser Asn Gly Pro Pro Ala Pro Gln Gly Ala 
            100                 105                 110         


Ser Glu Glu Pro Ser Gly Thr Gln Ser Glu Gly Gly Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ala Gly Ser Pro Gly Pro Pro Gly Ile Leu Arg Pro Leu Gln 
    130                 135                 140                 


Pro Pro Gln Arg Ala Asp Thr Pro Arg Arg Asn Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ser Pro Ser Glu Arg Pro Arg Gln Lys Leu Ser Arg Lys Ala Ile Ser 
                165                 170                 175     


Ser Ala Asn Leu Leu Val Arg Ser Gly Ser Thr Glu Ser Arg Gly Gly 
            180                 185                 190         


Lys Asp Pro Leu Ser Ser Pro Gly Gly Pro Gly Ser Arg Arg Ser Asn 
        195                 200                 205             


Tyr Asn Leu Glu Gly Ile Ser Val Lys Met Phe Leu Arg Gly Arg Pro 
    210                 215                 220                 


Ile Thr Met Tyr Ile Pro Ser Gly Ile Arg Ser Leu Glu Glu Leu Pro 
225                 230                 235                 240 


Ser Gly Pro Pro Pro Glu Thr Leu Ser Leu Asp Trp Val Tyr Gly Tyr 
                245                 250                 255     


Arg Gly Arg Asp Ser Arg Ser Asn Leu Phe Val Leu Arg Ser Gly Glu 
            260                 265                 270         


Val Val Tyr Phe Ile Ala Cys Val Val Val Leu Tyr Arg Pro Gly Gly 
        275                 280                 285             


Gly Pro Gly Gly Pro Gly Gly Gly Gly Gln Arg His Tyr Arg Gly His 
    290                 295                 300                 


Thr Asp Cys Val Arg Cys Leu Ala Val His Pro Asp Gly Val Arg Val 
305                 310                 315                 320 


Ala Ser Gly Gln Thr Ala Gly Val Asp Lys Asp Gly Lys Pro Leu Gln 
                325                 330                 335     


Pro Val Val His Ile Trp Asp Ser Glu Thr Leu Leu Lys Leu Gln Glu 
            340                 345                 350         


Ile Gly Leu Gly Ala Phe Glu Arg Gly Val Gly Ala Leu Ala Phe Ser 
        355                 360                 365             


Ala Ala Asp Gln Gly Ala Phe Leu Cys Val Val Asp Asp Ser Asn Glu 
    370                 375                 380                 


His Met Leu Ser Val Trp Asp Cys Ser Arg Gly Met Lys Leu Ala Glu 
385                 390                 395                 400 


Ile Lys Ser Thr Asn Asp Ser Val Leu Ala Val Gly Phe Asn Pro Arg 
                405                 410                 415     


Asp Ser Ser Cys Ile Val Thr Ser Gly Lys Ser His Val His Phe Trp 
            420                 425                 430         


Asn Trp Ser Gly Gly Val Gly Val Pro Gly Asn Gly Thr Leu Thr Arg 
        435                 440                 445             


Lys Gln Gly Val Phe Gly Lys Tyr Lys Lys Pro Lys Phe Ile Pro Cys 
    450                 455                 460                 


Phe Val Phe Leu Pro Asp Gly Asp Ile Leu Thr Gly Asp Ser Glu Gly 
465                 470                 475                 480 


Asn Ile Leu Thr Trp Gly Arg Ser Pro Ser Asp Ser Lys Thr Pro Gly 
                485                 490                 495     


Arg Gly Gly Ala Lys Glu Thr Tyr Gly Ile Val Ala Gln Ala His Ala 
            500                 505                 510         


His Glu Gly Ser Ile Phe Ala Leu Cys Leu Arg Arg Asp Gly Thr Val 
        515                 520                 525             


Leu Ser Gly Gly Gly Arg Asp Arg Arg Leu Val Gln Trp Gly Pro Gly 
    530                 535                 540                 


Leu Val Ala Leu Gln Glu Ala Glu Ile Pro Glu His Phe Gly Ala Val 
545                 550                 555                 560 


Arg Ala Ile Ala Glu Gly Leu Gly Ser Glu Leu Leu Val Gly Thr Thr 
                565                 570                 575     


Lys Asn Ala Leu Leu Arg Gly Asp Leu Ala Gln Gly Phe Ser Pro Val 
            580                 585                 590         


Ile Gln Gly His Thr Asp Glu Leu Trp Gly Leu Cys Thr His Pro Ser 
        595                 600                 605             


Gln Asn Arg Phe Leu Thr Cys Gly His Asp Arg Gln Leu Cys Leu Trp 
    610                 615                 620                 


Asp Gly Glu Ser His Ala Leu Ala Trp Ser Ile Asp Leu Lys Glu Thr 
625                 630                 635                 640 


Gly Leu Cys Ala Asp Phe His Pro Ser Gly Ala Val Val Ala Val Gly 
                645                 650                 655     


Leu Asn Thr Gly Arg Trp Leu Val Leu Asp Thr Glu Thr Arg Glu Ile 
            660                 665                 670         


Val Ser Asp Val Ile Asp Gly Asn Glu Gln Leu Ser Val Val Arg Tyr 
        675                 680                 685             


Ser Pro Asp Gly Leu Tyr Leu Ala Ile Gly Ser His Asp Asn Val Ile 
    690                 695                 700                 


Tyr Ile Tyr Ser Val Ser Ser Asp Gly Ala Lys Ser Ser Arg Phe Gly 
705                 710                 715                 720 


Arg Cys Met Gly His Ser Ser Phe Ile Thr His Leu Asp Trp Ser Lys 
                725                 730                 735     


Asp Gly Asn Phe Ile Met Ser Asn Ser Gly Asp Tyr Glu Ile Leu Tyr 
            740                 745                 750         


Trp Asp Val Ala Gly Gly Cys Lys Gln Leu Lys Asn Arg Tyr Glu Ser 
        755                 760                 765             


Arg Asp Arg Glu Trp Ala Thr Tyr Thr Cys Val Leu Gly Phe His Val 
    770                 775                 780                 


Tyr Val Pro Val Arg Ser Cys Gln Gly Ala Glu Pro His Val Arg Gly 
785                 790                 795                 800 


Pro Arg Gln Pro Arg Asp Gln Arg Pro Ile His Ala Arg Arg Leu Ala 
                805                 810                 815     


Pro Arg Leu Ala Gly Arg Gln Gly Arg Gln His Leu Pro Val Ala Ser 
            820                 825                 830         


Ala Gly Arg Trp Gly Arg Gly Ala Gly Ala Arg His Ala Leu Ser Asn 
        835                 840                 845             


Pro Leu Pro Val Pro Arg Leu Leu Pro Arg Arg Leu Ile Ala Ala Trp 
    850                 855                 860                 


Arg Asp Arg Leu Ala Arg Arg Arg Gly Pro Ala Pro Pro Cys Pro Ser 
865                 870                 875                 880 


Leu Ala Gln Ser Pro Thr Thr Arg Gly Arg Leu Phe Pro Gly Leu Thr 
                885                 890                 895     


Ser Arg His Ser Arg Ser Arg Ile Phe Leu Glu Gly Ala Asn Gly Ala 
            900                 905                 910         


Pro Ala His Thr Val 
        915         


<210> 8608
<211> 106
<212> PRT
<213> Homo sapiens

<400> 8608
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu 
            100                 105     


<210> 8609
<211> 75
<212> PRT
<213> Homo sapiens

<400> 8609
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr 
65                  70                  75  


<210> 8610
<211> 424
<212> PRT
<213> Homo sapiens

<400> 8610
Met Asp Gln Pro Ser Gly Arg Ser Phe Met Gln Val Leu Cys Glu Lys 
1               5                   10                  15      


Tyr Ser Pro Glu Asn Phe Pro Tyr Arg Arg Gly Pro Gly Met Gly Val 
            20                  25                  30          


His Val Pro Ala Thr Pro Gln Gly Ser Pro Met Lys Asp Arg Leu Asn 
        35                  40                  45              


Leu Pro Ser Val Leu Val Leu Asn Ser Cys Gly Ile Thr Cys Ala Gly 
    50                  55                  60                  


Asp Glu Lys Glu Ile Ala Ala Phe Cys Ala His Val Ser Glu Leu Asp 
65                  70                  75                  80  


Leu Ser Asp Asn Lys Leu Glu Asp Trp His Glu Val Ser Lys Ile Val 
                85                  90                  95      


Ser Asn Val Pro Gln Leu Glu Phe Leu Asn Leu Ser Ser Asn Pro Leu 
            100                 105                 110         


Asn Leu Ser Val Leu Glu Arg Thr Cys Ala Gly Ser Phe Ser Gly Val 
        115                 120                 125             


Arg Lys Leu Val Leu Asn Asn Ser Lys Ala Ser Trp Glu Thr Val His 
    130                 135                 140                 


Met Ile Leu Gln Glu Leu Pro Asp Leu Glu Glu Leu Phe Leu Cys Leu 
145                 150                 155                 160 


Asn Asp Tyr Glu Thr Val Ser Cys Pro Ser Ile Cys Cys His Ser Leu 
                165                 170                 175     


Lys Leu Leu His Ile Thr Asp Asn Asn Leu Gln Asp Trp Thr Glu Ile 
            180                 185                 190         


Arg Lys Leu Gly Val Met Phe Pro Ser Leu Asp Thr Leu Val Leu Ala 
        195                 200                 205             


Asn Asn His Leu Asn Ala Ile Glu Glu Pro Asp Asp Ser Leu Ala Arg 
    210                 215                 220                 


Leu Phe Pro Asn Leu Arg Ser Ile Ser Leu His Lys Ser Gly Leu Gln 
225                 230                 235                 240 


Ser Trp Glu Asp Ile Asp Lys Leu Asn Ser Phe Pro Lys Leu Glu Glu 
                245                 250                 255     


Val Arg Leu Leu Gly Ile Pro Leu Leu Gln Pro Tyr Thr Thr Glu Glu 
            260                 265                 270         


Arg Arg Lys Leu Val Ile Ala Arg Leu Pro Ser Val Ser Lys Leu Asn 
        275                 280                 285             


Gly Ser Val Val Thr Asp Gly Glu Arg Glu Asp Ser Glu Arg Phe Phe 
    290                 295                 300                 


Ile Arg Tyr Tyr Val Asp Val Pro Gln Glu Glu Val Pro Phe Arg Tyr 
305                 310                 315                 320 


His Glu Leu Ile Thr Lys Tyr Gly Lys Leu Glu Pro Leu Ala Glu Val 
                325                 330                 335     


Asp Leu Arg Pro Gln Ser Ser Ala Lys Val Glu Val His Phe Asn Asp 
            340                 345                 350         


Gln Val Glu Glu Met Ser Ile Arg Leu Asp Gln Thr Val Ala Glu Leu 
        355                 360                 365             


Lys Lys Gln Leu Lys Thr Leu Val Gln Leu Pro Thr Ser Asn Met Leu 
    370                 375                 380                 


Leu Tyr Tyr Phe Asp His Glu Ala Pro Phe Gly Pro Glu Glu Met Lys 
385                 390                 395                 400 


Tyr Ser Ser Arg Ala Leu His Ser Phe Gly Ile Arg Asp Gly Asp Lys 
                405                 410                 415     


Ile Tyr Val Glu Ser Lys Thr Lys 
            420                 


<210> 8611
<211> 95
<212> PRT
<213> Homo sapiens

<400> 8611
Met Glu Ala Ala Asp Ala Ser Arg Ser Asn Gly Ser Ser Pro Glu Ala 
1               5                   10                  15      


Arg Asp Ala Arg Ser Pro Ser Gly Pro Ser Gly Ser Leu Glu Asn Gly 
            20                  25                  30          


Thr Lys Ala Asp Gly Lys Asp Ala Lys Thr Thr Asn Gly His Gly Gly 
        35                  40                  45              


Glu Ala Ala Glu Gly Lys Ser Leu Gly Ser Ala Leu Lys Pro Gly Glu 
    50                  55                  60                  


Gly Arg Ser Ala Leu Phe Ala Gly Asn Glu Trp Arg Arg Pro Ile Ile 
65                  70                  75                  80  


Gln Phe Val Glu Ser Gly Asp Asp Lys Asn Ser Asn Tyr Phe Ser 
                85                  90                  95  


<210> 8612
<211> 1047
<212> PRT
<213> Homo sapiens

<400> 8612
Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Glu Pro Ser Lys Ser Gln Thr Arg Lys Pro 
385                 390                 395                 400 


Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu Val 
                405                 410                 415     


Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val Pro 
            420                 425                 430         


Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu Glu 
        435                 440                 445             


Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys Gly 
    450                 455                 460                 


Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro Ala 
465                 470                 475                 480 


Gly Ala Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp Leu Gln Lys Trp 
                485                 490                 495     


Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn His Ala Cys Leu 
            500                 505                 510         


Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser Ile Met Lys Arg 
        515                 520                 525             


Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg Tyr Gly Gly Gly 
    530                 535                 540                 


Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys Val Val Glu Arg 
545                 550                 555                 560 


Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu Asp Tyr Lys Thr 
                565                 570                 575     


Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Ser Asp Gly Phe Trp 
            580                 585                 590         


Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala Leu Glu Gln 
        595                 600                 605             


Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly Lys Met Asn 
    610                 615                 620                 


Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg Lys Glu Glu 
625                 630                 635                 640 


Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His Ala Val Phe 
                645                 650                 655     


Phe Phe Ser Lys Tyr Ile Phe Leu Asn Ser Gly Glu Leu Cys Ile Ser 
            660                 665                 670         


Glu Asn Glu Arg Arg Leu Val Ser Lys Glu Ala Trp Ser Lys Leu Gln 
        675                 680                 685             


Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro Ser Tyr Lys Glu Cys Cys 
    690                 695                 700                 


Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly Glu Glu Asn Glu Ala Leu 
705                 710                 715                 720 


His Lys Met Ile Ala Asn Glu Gln Lys Thr Ser Leu Pro Asn Leu Phe 
                725                 730                 735     


Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn Trp Pro Glu Asp Thr Asp 
            740                 745                 750         


Val Leu Tyr Ile Val Ser Gln Phe Phe Val Glu Glu Trp Arg Lys Phe 
        755                 760                 765             


Val Arg Lys Pro Thr Arg Cys Ser Pro Val Ser Ser Val Gly Asn Ser 
    770                 775                 780                 


Ala Leu Leu Cys Pro His Gly Gly Leu Met Phe Thr Phe Ala Ser Met 
785                 790                 795                 800 


Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu Ile Trp Pro Ser Glu Trp 
                805                 810                 815     


Gln Met Ile Gln Lys Leu Phe Val Val Asp His Val Ile Lys Ile Thr 
            820                 825                 830         


Arg Ile Glu Val Gly Asp Val Asn Pro Ser Glu Thr Gln Tyr Ile Ser 
        835                 840                 845             


Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu Gly Leu Leu Cys Gln Gln 
    850                 855                 860                 


Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala Thr Ile Tyr Val His Lys 
865                 870                 875                 880 


Val Val Asp Asn Lys Lys Val Met Lys Asp Ser Ala Pro Glu Leu Asn 
                885                 890                 895     


Val Ser Ser Ser Glu Thr Glu Glu Asp Lys Glu Glu Ala Lys Pro Asp 
            900                 905                 910         


Gly Glu Lys Asp Pro Asp Phe Asn Gln Ser Asn Gly Gly Thr Lys Arg 
        915                 920                 925             


Gln Lys Ile Ser His Gln Asn Tyr Ile Ala Tyr Gln Lys Gln Val Ile 
    930                 935                 940                 


Arg Arg Ser Met Arg His Arg Lys Val Arg Gly Glu Lys Ala Leu Leu 
945                 950                 955                 960 


Val Ser Ala Asn Gln Thr Leu Lys Glu Leu Lys Ile Gln Ile Met His 
                965                 970                 975     


Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser Ile Asp Gly Lys 
            980                 985                 990         


Ile Leu Ser Asp Asp Cys Ala Thr  Leu Gly Thr Leu Gly  Val Ile Pro 
        995                 1000                 1005             


Glu Ser  Val Ile Leu Leu Lys  Ala Asp Glu Pro Ile  Ala Asp Tyr 
    1010                 1015                 1020             


Ala Ala  Met Asp Asp Val Met  Gln Val Cys Met Pro  Glu Glu Gly 
    1025                 1030                 1035             


Phe Lys  Gly Thr Gly Leu Leu  Gly His 
    1040                 1045         


<210> 8613
<211> 480
<212> PRT
<213> Homo sapiens

<400> 8613
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser Leu 
        115                 120                 125             


Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys Gln 
    130                 135                 140                 


Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val Gln 
145                 150                 155                 160 


Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr Val 
                165                 170                 175     


Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile Asn 
            180                 185                 190         


Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile Met 
        195                 200                 205             


Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser Ser 
    210                 215                 220                 


Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly Val 
225                 230                 235                 240 


Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser Phe 
                245                 250                 255     


Ser Thr Ser Pro Pro Ser Gln Leu Met Val Pro Gly Lys Glu Gly Gly 
            260                 265                 270         


Val Pro Leu Ala Pro Asn Gln Pro Val His Gly Thr Gln Ala Asp Gln 
        275                 280                 285             


Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg Thr His Cys Ala Ala 
    290                 295                 300                 


Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val Ser Asn Ser Ser Glu 
305                 310                 315                 320 


Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr Ile Phe Val Arg Lys 
                325                 330                 335     


Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln Val Thr Leu Thr Ser 
            340                 345                 350         


Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys Asn Leu Glu Leu Glu 
        355                 360                 365             


Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser Pro Glu Thr Glu Ser 
    370                 375                 380                 


Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asn Thr His Asp Asp Phe Val Met Ile Asp Phe Lys Pro Ala Phe 
                405                 410                 415     


Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly Thr Phe Tyr Arg Glu 
            420                 425                 430         


Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser Ile Asp Ile Gly Ala 
        435                 440                 445             


Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro Glu Lys Leu Ala Val 
    450                 455                 460                 


His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe Val Glu Thr Leu Gln 
465                 470                 475                 480 


<210> 8614
<211> 791
<212> PRT
<213> Homo sapiens

<400> 8614
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu Asn Glu Glu Lys Ile Ile 
            180                 185                 190         


Gln Arg Leu Val Glu Ile Val His Pro Ser Gln Glu Glu Asp Arg His 
        195                 200                 205             


Ser Asn Ala Ser Gln Ser Leu Cys Glu Ile Val Arg Leu Ser Arg Asp 
    210                 215                 220                 


Gln Met Leu Gln Ile Gln Asn Ser Thr Glu Pro Asp Pro Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Lys Gln Glu Ile Ile Glu Gln Leu Leu Ser Asn Ile Phe 
                245                 250                 255     


His Lys Glu Lys Asn Glu Ser Ala Ile Val Ser Ala Ile Gln Ile Leu 
            260                 265                 270         


Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His Ile Glu 
        275                 280                 285             


Ile Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn Lys Ser 
    290                 295                 300                 


Val Leu Glu Ala Ile Arg Gly Arg Leu Gly Ser Phe His Glu Leu Leu 
305                 310                 315                 320 


Leu Glu Pro Pro Lys Asn Met Phe Phe Lys Tyr Thr Trp Asn Asn Phe 
                325                 330                 335     


Leu His Thr Gln Val Glu Ile Cys Ile Ala Leu Ile Leu Ala Ser Pro 
            340                 345                 350         


Phe Glu Asn Thr Glu Asn Ala Thr Ile Thr Asp Gln Asp Ser Thr Gly 
        355                 360                 365             


Asp Asn Leu Leu Leu Lys His Leu Phe Gln Lys Cys Gln Leu Ile Glu 
    370                 375                 380                 


Arg Ile Leu Glu Ala Trp Glu Met Asn Glu Lys Lys Gln Ala Glu Gly 
385                 390                 395                 400 


Gly Arg Arg His Gly Tyr Met Gly His Leu Thr Arg Ile Ala Asn Cys 
                405                 410                 415     


Ile Val His Ser Thr Asp Lys Gly Pro Asn Ser Ala Leu Val Gln Gln 
            420                 425                 430         


Leu Ile Lys Asp Leu Pro Asp Glu Val Arg Glu Arg Trp Glu Thr Phe 
        435                 440                 445             


Cys Thr Ser Ser Leu Gly Glu Thr Asn Lys Arg Asn Thr Val Asp Leu 
    450                 455                 460                 


Ala Phe Ser Asp Tyr Gln Met Gln Gln Met Thr Ser Asn Phe Ile Asp 
465                 470                 475                 480 


Gln Phe Gly Phe Asn Asp Glu Lys Phe Ala Asp Gln Asp Asp Ile Gly 
                485                 490                 495     


Asn Val Ser Phe Asp Arg Val Ser Asp Ile Asn Phe Thr Leu Asn Thr 
            500                 505                 510         


Asn Glu Ser Gly Asn Ile Ala Leu Phe Glu Ala Cys Cys Lys Glu Arg 
        515                 520                 525             


Ile Gln Gln Phe Asp Asp Gly Gly Ser Asp Glu Glu Asp Ile Trp Glu 
    530                 535                 540                 


Glu Lys His Ile Ala Phe Thr Pro Glu Ser Gln Arg Arg Ser Ser Ser 
545                 550                 555                 560 


Gly Ser Thr Asp Ser Glu Glu Ser Thr Asp Ser Glu Glu Glu Asp Gly 
                565                 570                 575     


Ala Lys Gln Asp Leu Phe Glu Pro Ser Ser Ala Asn Thr Glu Asp Lys 
            580                 585                 590         


Met Glu Val Asp Leu Ser Glu Pro Pro Asn Trp Ser Ala Asn Phe Asp 
        595                 600                 605             


Val Pro Met Glu Thr Thr His Gly Ala Pro Leu Asp Ser Val Gly Ser 
    610                 615                 620                 


Asp Val Trp Ser Thr Glu Glu Pro Met Pro Thr Lys Glu Thr Gly Trp 
625                 630                 635                 640 


Ala Ser Phe Ser Glu Phe Thr Ser Ser Leu Ser Thr Lys Asp Ser Leu 
                645                 650                 655     


Arg Ser Asn Ser Pro Val Glu Met Glu Thr Ser Thr Glu Pro Met Asp 
            660                 665                 670         


Pro Leu Thr Pro Ser Ala Ala Ala Leu Ala Val Gln Pro Glu Ala Ala 
        675                 680                 685             


Gly Ser Val Ala Met Glu Ala Ser Ser Asp Gly Glu Glu Asp Ala Glu 
    690                 695                 700                 


Ser Thr Asp Lys Val Thr Glu Thr Val Met Asn Gly Gly Met Lys Glu 
705                 710                 715                 720 


Thr Leu Ser Leu Thr Val Asp Ala Lys Thr Glu Thr Ala Val Phe Lys 
                725                 730                 735     


Ser Glu Glu Gly Lys Leu Ser Thr Ser Gln Asp Ala Ala Cys Lys Asp 
            740                 745                 750         


Ala Glu Glu Cys Pro Glu Thr Ala Glu Ala Lys Cys Ala Ala Pro Arg 
        755                 760                 765             


Pro Pro Ser Ser Ser Pro Glu Gln Ser Gly Val Glu Ile Pro Ala Leu 
    770                 775                 780                 


Pro Gly Gln Trp Ser Gln Gln 
785                 790     


<210> 8615
<211> 499
<212> PRT
<213> Homo sapiens

<400> 8615
Met Phe Gly Asp Ala Ser Thr Ser Leu Val Val Pro Glu Lys Val Lys 
1               5                   10                  15      


Thr Pro Met Lys Ser Ser Lys Thr Asp Leu Gln Gly Ser Ala Ser Pro 
            20                  25                  30          


Ser Lys Val Glu Gly Val His Thr Pro Arg Gln Lys Arg Ser Thr Pro 
        35                  40                  45              


Leu Lys Glu Arg Gln Leu Ser Lys Pro Leu Ser Glu Arg Thr Asn Ser 
    50                  55                  60                  


Ser Asp Ser Glu Arg Ser Pro Asp Leu Gly His Ser Thr Gln Ile Pro 
65                  70                  75                  80  


Arg Lys Val Val Tyr Asp Gln Leu Asn Gln Ile Leu Val Ser Asp Ala 
                85                  90                  95      


Ala Leu Pro Glu Asn Val Ile Leu Val Asn Thr Thr Asp Trp Gln Gly 
            100                 105                 110         


Gln Tyr Val Ala Glu Leu Leu Gln Asp Gln Arg Lys Pro Val Val Cys 
        115                 120                 125             


Thr Cys Ser Thr Val Glu Val Gln Ala Val Leu Ser Ala Leu Leu Thr 
    130                 135                 140                 


Arg Ile Gln Arg Tyr Cys Asn Cys Asn Ser Ser Met Pro Arg Pro Val 
145                 150                 155                 160 


Lys Val Ala Ala Val Gly Gly Gln Ser Tyr Leu Ser Ser Ile Leu Arg 
                165                 170                 175     


Phe Phe Val Lys Ser Leu Ala Asn Lys Thr Ser Asp Trp Leu Gly Tyr 
            180                 185                 190         


Met Arg Phe Leu Ile Ile Pro Leu Gly Ser His Pro Val Ala Lys Tyr 
        195                 200                 205             


Leu Gly Ser Val Asp Ser Lys Tyr Ser Ser Ser Phe Leu Asp Ser Gly 
    210                 215                 220                 


Trp Arg Asp Leu Phe Ser Arg Ser Glu Pro Pro Val Ser Glu Gln Leu 
225                 230                 235                 240 


Asp Val Ala Gly Arg Val Met Gln Tyr Val Asn Gly Ala Ala Thr Thr 
                245                 250                 255     


His Gln Leu Pro Val Ala Glu Ala Met Leu Thr Cys Arg His Lys Phe 
            260                 265                 270         


Pro Asp Glu Asp Ser Tyr Gln Lys Phe Ile Pro Phe Ile Gly Val Val 
        275                 280                 285             


Lys Val Gly Leu Val Glu Asp Ser Pro Ser Thr Ala Gly Asp Gly Asp 
    290                 295                 300                 


Asp Ser Pro Val Val Ser Leu Thr Val Pro Ser Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Ser Ser Gly Leu Ser Arg Asp Ala Thr Ala Thr Pro Pro Ser Ser Pro 
                325                 330                 335     


Ser Met Ser Ser Ala Leu Ala Ile Val Gly Ser Pro Asn Ser Pro Tyr 
            340                 345                 350         


Gly Asp Val Ile Gly Leu Gln Val Asp Tyr Trp Leu Gly His Pro Gly 
        355                 360                 365             


Glu Arg Arg Arg Glu Gly Asp Lys Arg Asp Ala Ser Ser Lys Asn Thr 
    370                 375                 380                 


Leu Lys Ser Val Phe Arg Ser Val Gln Val Ser Arg Leu Pro His Ser 
385                 390                 395                 400 


Gly Glu Ala Gln Leu Ser Gly Thr Met Ala Met Thr Val Val Thr Lys 
                405                 410                 415     


Glu Lys Asn Lys Lys Val Pro Thr Ile Phe Leu Ser Lys Lys Pro Arg 
            420                 425                 430         


Glu Lys Glu Val Asp Ser Lys Ser Gln Val Ile Glu Gly Ile Ser Arg 
        435                 440                 445             


Leu Ile Cys Ser Ala Lys Gln Gln Gln Thr Met Leu Arg Val Ser Ile 
    450                 455                 460                 


Asp Gly Val Glu Trp Ser Asp Ile Lys Phe Phe Gln Leu Ala Ala Gln 
465                 470                 475                 480 


Trp Pro Thr His Val Lys His Phe Pro Val Gly Leu Phe Ser Gly Ser 
                485                 490                 495     


Lys Ala Thr 
            


<210> 8616
<211> 144
<212> PRT
<213> Homo sapiens

<400> 8616
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser Glu 
    130                 135                 140                 


<210> 8617
<211> 170
<212> PRT
<213> Homo sapiens

<400> 8617
Met Ala Ser Glu Ala Glu Lys Thr Phe His Arg Phe Ala Ala Phe Gly 
1               5                   10                  15      


Glu Ser Ser Ser Ser Gly Thr Glu Met Asn Asn Lys Asn Phe Ser Lys 
            20                  25                  30          


Leu Cys Lys Asp Cys Gly Ile Met Asp Gly Lys Thr Val Thr Ser Thr 
        35                  40                  45              


Asp Val Asp Ile Val Phe Ser Lys Val Lys Ala Lys Asn Ala Arg Thr 
    50                  55                  60                  


Ile Thr Phe Gln Gln Phe Lys Glu Ala Val Lys Glu Leu Gly Gln Lys 
65                  70                  75                  80  


Arg Phe Lys Gly Lys Ser Pro Asp Glu Val Leu Glu Asn Ile Tyr Gly 
                85                  90                  95      


Leu Met Glu Gly Lys Asp Pro Ala Thr Thr Gly Ala Thr Lys Ala Thr 
            100                 105                 110         


Thr Val Gly Ala Val Asp Arg Leu Thr Asp Thr Ser Lys Tyr Thr Gly 
        115                 120                 125             


Thr His Lys Glu Arg Phe Asp Glu Ser Gly Lys Gly Lys Gly Ile Ala 
    130                 135                 140                 


Gly Arg Glu Glu Met Thr Asp Asn Thr Gly Tyr Val Ser Gly Tyr Lys 
145                 150                 155                 160 


Gly Ser Gly Thr Tyr Asp Lys Lys Thr Lys 
                165                 170 


<210> 8618
<211> 89
<212> PRT
<213> Homo sapiens

<400> 8618
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala 
                85                  


<210> 8619
<211> 401
<212> PRT
<213> Homo sapiens

<400> 8619
Met Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu 
1               5                   10                  15      


Leu Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile 
            20                  25                  30          


Lys Val Ser Tyr Thr Val Tyr Asn Arg Leu Ser Leu Leu Leu Lys Ser 
        35                  40                  45              


Leu Leu Ala Ile Thr Arg Val Thr Pro Ala Tyr Arg Leu Ser Arg Lys 
    50                  55                  60                  


Gln Gly His Glu Tyr Val Ile Leu Tyr Arg Ile Tyr Phe Gly Glu Val 
65                  70                  75                  80  


Gln Leu Ser Gly Leu Gly Glu Gly Phe Gln Thr Val Arg Val Gly Thr 
                85                  90                  95      


Val Gly Thr Pro Val Gly Thr Ile Thr Leu Ser Cys Ala Tyr Arg Ile 
            100                 105                 110         


Asn Leu Ala Phe Met Ser Thr Arg Gln Phe Glu Arg Thr Pro Pro Ile 
        115                 120                 125             


Met Gly Ile Ile Ile Asp His Phe Val Asp Arg Pro Tyr Pro Ser Ser 
    130                 135                 140                 


Ser Pro Met His Pro Cys Asn Tyr Arg Thr Ala Gly Glu Asp Thr Gly 
145                 150                 155                 160 


Val Ile Tyr Pro Ser Val Glu Asp Ser Gln Glu Val Cys Thr Thr Ser 
                165                 170                 175     


Phe Ser Thr Ser Pro Pro Ser Gln Leu Met Val Pro Gly Lys Glu Gly 
            180                 185                 190         


Gly Val Pro Leu Ala Pro Asn Gln Pro Val His Gly Thr Gln Ala Asp 
        195                 200                 205             


Gln Glu Arg Leu Ala Thr Cys Thr Pro Ser Asp Arg Thr His Cys Ala 
    210                 215                 220                 


Ala Thr Pro Ser Ser Ser Glu Asp Thr Glu Thr Val Ser Asn Ser Ser 
225                 230                 235                 240 


Glu Gly Arg Ala Ser Pro His Asp Val Leu Glu Thr Ile Phe Val Arg 
                245                 250                 255     


Lys Val Gly Ala Phe Val Asn Lys Pro Ile Asn Gln Val Thr Leu Thr 
            260                 265                 270         


Ser Leu Asp Ile Pro Phe Ala Met Phe Ala Pro Lys Asn Leu Glu Leu 
        275                 280                 285             


Glu Asp Thr Asp Pro Met Val Asn Pro Pro Asp Ser Pro Glu Thr Glu 
    290                 295                 300                 


Ser Pro Leu Gln Gly Ser Leu His Ser Asp Gly Ser Ser Gly Gly Ser 
305                 310                 315                 320 


Ser Gly Asn Thr His Asp Asp Phe Val Met Ile Asp Phe Lys Pro Ala 
                325                 330                 335     


Phe Ser Lys Asp Asp Ile Leu Pro Met Asp Leu Gly Thr Phe Tyr Arg 
            340                 345                 350         


Glu Phe Gln Asn Pro Pro Gln Leu Ser Ser Leu Ser Ile Asp Ile Gly 
        355                 360                 365             


Ala Gln Ser Met Ala Glu Asp Leu Asp Ser Leu Pro Glu Lys Leu Ala 
    370                 375                 380                 


Val His Glu Lys Asn Val Arg Glu Phe Asp Ala Phe Val Glu Thr Leu 
385                 390                 395                 400 


Gln 
    


<210> 8620
<211> 715
<212> PRT
<213> Homo sapiens

<400> 8620
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val Gln 
65                  70                  75                  80  


Leu Ser Ser Lys Glu Lys Ile Trp Thr Gln Glu Met Leu Leu Gln Val 
                85                  90                  95      


Asn Asp Gln Ser Leu Arg Leu Leu Asp Ile Glu Ser Gln Glu Glu Leu 
            100                 105                 110         


Glu Asp Phe Pro Leu Pro Thr Val Gln Arg Ser Gln Thr Val Leu Asn 
        115                 120                 125             


Gln Leu Arg Tyr Pro Ser Val Leu Leu Leu Val Cys Gln Asp Ser Glu 
    130                 135                 140                 


Gln Ser Lys Pro Asp Val His Phe Phe His Cys Asp Glu Val Glu Ala 
145                 150                 155                 160 


Glu Leu Val His Glu Asp Ile Glu Ser Ala Leu Ala Asp Cys Arg Leu 
                165                 170                 175     


Gly Lys Lys Met Arg Pro Gln Thr Leu Lys Gly His Gln Glu Lys Ile 
            180                 185                 190         


Arg Gln Arg Gln Ser Ile Leu Pro Pro Pro Gln Gly Pro Ala Pro Ile 
        195                 200                 205             


Pro Phe Gln His Arg Gly Gly Asp Ser Pro Glu Ala Lys Asn Arg Val 
    210                 215                 220                 


Gly Pro Gln Val Pro Leu Ser Glu Pro Gly Phe Arg Arg Arg Glu Ser 
225                 230                 235                 240 


Gln Glu Glu Pro Arg Ala Val Leu Ala Gln Lys Ile Glu Lys Glu Thr 
                245                 250                 255     


Gln Ile Leu Asn Cys Ala Leu Asp Asp Ile Glu Trp Phe Val Ala Arg 
            260                 265                 270         


Leu Gln Lys Ala Ala Glu Ala Phe Lys Gln Leu Asn Gln Arg Lys Lys 
        275                 280                 285             


Gly Lys Lys Lys Gly Lys Lys Ala Pro Ala Glu Gly Val Leu Thr Leu 
    290                 295                 300                 


Arg Ala Arg Pro Pro Ser Glu Gly Glu Phe Ile Asp Cys Phe Gln Lys 
305                 310                 315                 320 


Ile Lys Leu Ala Ile Asn Leu Leu Ala Lys Leu Gln Lys His Ile Gln 
                325                 330                 335     


Asn Pro Ser Ala Ala Glu Leu Val His Phe Leu Phe Gly Pro Leu Asp 
            340                 345                 350         


Leu Ile Val Asn Thr Cys Ser Gly Pro Asp Ile Ala Arg Ser Val Ser 
        355                 360                 365             


Cys Pro Leu Leu Ser Arg Asp Ala Val Asp Phe Leu Arg Gly His Leu 
    370                 375                 380                 


Val Pro Lys Glu Met Ser Leu Trp Glu Ser Leu Gly Glu Ser Trp Met 
385                 390                 395                 400 


Arg Pro Arg Ser Glu Trp Pro Arg Glu Pro Gln Val Pro Leu Tyr Val 
                405                 410                 415     


Pro Lys Phe His Ser Gly Trp Glu Pro Pro Val Asp Val Leu Gln Glu 
            420                 425                 430         


Ala Pro Trp Glu Val Glu Gly Leu Ala Ser Ala Pro Ile Glu Glu Val 
        435                 440                 445             


Ser Pro Val Ser Arg Gln Ser Ile Arg Asn Ser Gln Lys His Ser Pro 
    450                 455                 460                 


Thr Ser Glu Pro Thr Pro Pro Gly Asp Ala Leu Pro Pro Val Ser Ser 
465                 470                 475                 480 


Pro His Thr His Arg Gly Tyr Gln Pro Thr Pro Ala Met Ala Lys Tyr 
                485                 490                 495     


Val Lys Ile Leu Tyr Asp Phe Thr Ala Arg Asn Ala Asn Glu Leu Ser 
            500                 505                 510         


Val Leu Lys Asp Glu Val Leu Glu Val Leu Glu Asp Gly Arg Gln Trp 
        515                 520                 525             


Trp Lys Leu Arg Ser Arg Ser Gly Gln Ala Gly Tyr Val Pro Cys Asn 
    530                 535                 540                 


Ile Leu Gly Glu Ala Arg Pro Glu Asp Ala Gly Ala Pro Phe Glu Gln 
545                 550                 555                 560 


Ala Gly Gln Lys Tyr Trp Gly Pro Ala Ser Pro Thr His Lys Leu Pro 
                565                 570                 575     


Pro Ser Phe Pro Gly Asn Lys Asp Glu Leu Met Gln His Met Asp Glu 
            580                 585                 590         


Val Asn Asp Glu Leu Ile Arg Lys Ile Ser Asn Ile Arg Ala Gln Pro 
        595                 600                 605             


Gln Arg His Phe Arg Val Glu Arg Ser Gln Pro Val Ser Gln Pro Leu 
    610                 615                 620                 


Thr Tyr Glu Ser Gly Pro Asp Glu Val Arg Ala Trp Leu Glu Ala Lys 
625                 630                 635                 640 


Ala Phe Ser Pro Arg Ile Val Glu Asn Leu Gly Ile Leu Thr Gly Pro 
                645                 650                 655     


Gln Leu Phe Ser Leu Asn Lys Glu Glu Leu Lys Lys Val Cys Gly Glu 
            660                 665                 670         


Glu Gly Val Arg Val Tyr Ser Gln Leu Thr Met Gln Lys Ala Phe Leu 
        675                 680                 685             


Glu Lys Gln Gln Ser Gly Ser Glu Leu Glu Glu Leu Met Asn Lys Phe 
    690                 695                 700                 


His Ser Met Asn Gln Arg Arg Gly Glu Asp Ser 
705                 710                 715 


<210> 8621
<211> 111
<212> PRT
<213> Homo sapiens

<400> 8621
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg 
            100                 105                 110     


<210> 8622
<211> 75
<212> PRT
<213> Homo sapiens

<400> 8622
Met Ala Gly Gln Glu Asp Pro Val Gln Arg Glu Ile His Gln Asp Trp 
1               5                   10                  15      


Ala Asn Arg Glu Tyr Ile Glu Ile Ile Thr Ser Ser Ile Lys Lys Ile 
            20                  25                  30          


Ala Asp Phe Leu Asn Ser Phe Asp Met Ser Cys Arg Ser Arg Leu Ala 
        35                  40                  45              


Thr Leu Asn Glu Lys Leu Thr Ala Leu Glu Arg Arg Ile Glu Tyr Ile 
    50                  55                  60                  


Glu Ala Arg Val Thr Lys Gly Glu Thr Leu Thr 
65                  70                  75  


<210> 8623
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8623
Met Arg Tyr Val Ala Ser Tyr Leu Leu Ala Ala Leu Gly Gly Asn Ser 
1               5                   10                  15      


Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly Ile 
            20                  25                  30          


Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly 
        35                  40                  45              


Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala Ser 
    50                  55                  60                  


Val Pro Ala Gly Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala 
65                  70                  75                  80  


Ala Pro Ala Ala Gly Ser Ala Pro Ala Ala Ala Glu Glu Lys Lys Asp 
                85                  90                  95      


Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly 
            100                 105                 110         


Leu Phe Asp 
        115 


<210> 8624
<211> 358
<212> PRT
<213> Homo sapiens

<400> 8624
Met Pro Gly Cys Glu Leu Pro Val Gly Thr Cys Pro Asp Met Cys Pro 
1               5                   10                  15      


Ala Ala Glu Arg Ala Gln Arg Glu Arg Glu His Arg Leu His Arg Leu 
            20                  25                  30          


Glu Val Val Pro Gly Cys Arg Gln Asp Pro Pro Arg Ala Asp Pro Gln 
        35                  40                  45              


Arg Ala Val Lys Glu Tyr Ser Arg Pro Ala Ala Gly Lys Pro Arg Pro 
    50                  55                  60                  


Pro Pro Ser Gln Leu Arg Pro Pro Ser Val Leu Leu Ala Thr Val Arg 
65                  70                  75                  80  


Tyr Leu Ala Gly Glu Val Ala Glu Ser Ala Asp Ile Ala Arg Ala Glu 
                85                  90                  95      


Val Ala Ser Phe Val Ala Asp Arg Leu Arg Ala Val Leu Leu Asp Leu 
            100                 105                 110         


Ala Leu Gln Gly Ala Gly Asp Ala Glu Ala Ala Val Val Leu Glu Ala 
        115                 120                 125             


Ala Leu Ala Thr Leu Leu Thr Val Val Ala Arg Leu Gly Pro Asp Ala 
    130                 135                 140                 


Ala Arg Gly Pro Ala Asp Pro Val Leu Leu Gln Ala Gln Val Gln Glu 
145                 150                 155                 160 


Gly Phe Gly Ser Leu Arg Arg Cys Tyr Ala Arg Gly Ala Gly Pro His 
                165                 170                 175     


Pro Arg Gln Pro Ala Phe Gln Gly Leu Phe Leu Leu Tyr Asn Leu Gly 
            180                 185                 190         


Ser Val Glu Ala Leu His Glu Val Leu Gln Leu Pro Ala Ala Leu Arg 
        195                 200                 205             


Ala Cys Pro Pro Leu Arg Lys Ala Leu Ala Val Asp Ala Ala Phe Arg 
    210                 215                 220                 


Glu Gly Asn Ala Ala Arg Leu Phe Arg Leu Leu Gln Thr Leu Pro Tyr 
225                 230                 235                 240 


Leu Pro Ser Cys Ala Val Gln Cys His Val Gly His Ala Arg Arg Glu 
                245                 250                 255     


Ala Leu Ala Arg Phe Ala Arg Ala Phe Ser Thr Pro Lys Gly Gln Thr 
            260                 265                 270         


Leu Pro Leu Gly Phe Met Val Asn Leu Leu Ala Leu Asp Gly Leu Arg 
        275                 280                 285             


Glu Ala Arg Asp Leu Cys Gln Ala His Gly Leu Pro Leu Asp Gly Glu 
    290                 295                 300                 


Glu Arg Val Val Phe Leu Arg Gly Arg Tyr Val Glu Glu Gly Leu Pro 
305                 310                 315                 320 


Pro Ala Ser Thr Cys Lys Val Leu Val Glu Ser Lys Leu Arg Gly Arg 
                325                 330                 335     


Thr Leu Glu Glu Val Val Met Ala Glu Glu Glu Asp Glu Gly Thr Asp 
            340                 345                 350         


Arg Pro Gly Ser Pro Ala 
        355             


<210> 8625
<211> 1348
<212> PRT
<213> Homo sapiens

<400> 8625
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Ala Gly Asn Pro Leu Val Gln 
        35                  40                  45              


Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn Pro Ala Pro Gly Leu 
    50                  55                  60                  


Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro Val Gln Val Met Gln 
65                  70                  75                  80  


Asn Ala Asn His Val Thr Ser Ser Pro Val Ala Ser Gln Pro Ile Phe 
                85                  90                  95      


Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val Arg Pro Val Gln Asn 
            100                 105                 110         


Ala Met Asn Gln Val Gly Ile Val Leu Asn Val Gln Gln Gly Gln Thr 
        115                 120                 125             


Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly Thr Gln Phe Val Lys 
    130                 135                 140                 


Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln Met Thr Pro Val Arg 
145                 150                 155                 160 


Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr Asn Thr Phe Thr Thr 
                165                 170                 175     


Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr Val Pro Gln Ser Gln 
            180                 185                 190         


Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser Thr Thr Pro Thr Ala 
        195                 200                 205             


Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val Gln Ser Pro Gly Gln 
    210                 215                 220                 


Ser Asn Gln Thr Thr Asn Pro Lys Leu Val Ser Ile Ala Ser Phe Val 
225                 230                 235                 240 


Thr Val Lys Arg Pro Gly Val Thr Gly Glu Asn Ser Asn Glu Val Ala 
                245                 250                 255     


Lys Leu Val Asn Thr Leu Asn Thr Ile Pro Ser Leu Gly Gln Ser Pro 
            260                 265                 270         


Gly Pro Val Val Val Ser Asn Asn Ser Ser Ala His Gly Ser Gln Arg 
        275                 280                 285             


Thr Ser Gly Pro Glu Ser Ser Met Lys Val Thr Ser Ser Ile Pro Val 
    290                 295                 300                 


Phe Asp Leu Gln Asp Gly Gly Arg Lys Ile Cys Pro Arg Cys Asn Ala 
305                 310                 315                 320 


Gln Phe Arg Val Thr Glu Ala Leu Arg Gly His Met Cys Tyr Cys Cys 
                325                 330                 335     


Pro Glu Met Val Glu Tyr Gln Lys Lys Gly Lys Ser Leu Asp Ser Glu 
            340                 345                 350         


Pro Ser Val Pro Ser Ala Ala Lys Pro Pro Ser Pro Glu Lys Thr Ala 
        355                 360                 365             


Pro Val Ala Ser Thr Pro Ser Ser Thr Pro Ile Pro Ala Leu Ser Pro 
    370                 375                 380                 


Pro Thr Lys Val Pro Glu Pro Asn Glu Asn Val Gly Asp Ala Val Gln 
385                 390                 395                 400 


Thr Lys Leu Ile Met Leu Val Asp Asp Phe Tyr Tyr Gly Arg Asp Gly 
                405                 410                 415     


Gly Lys Val Ala Gln Leu Thr Asn Phe Pro Lys Val Ala Thr Ser Phe 
            420                 425                 430         


Arg Cys Pro His Cys Thr Lys Arg Leu Lys Asn Asn Ile Arg Phe Met 
        435                 440                 445             


Asn His Met Lys His His Val Glu Leu Asp Gln Gln Asn Gly Glu Val 
    450                 455                 460                 


Asp Gly His Thr Ile Cys Gln His Cys Tyr Arg Gln Phe Ser Thr Pro 
465                 470                 475                 480 


Phe Gln Leu Gln Cys His Leu Glu Asn Val His Ser Pro Tyr Glu Ser 
                485                 490                 495     


Thr Thr Lys Cys Lys Ile Cys Glu Trp Ala Phe Glu Ser Glu Pro Leu 
            500                 505                 510         


Phe Leu Gln His Met Lys Asp Thr His Lys Pro Gly Glu Met Pro Tyr 
        515                 520                 525             


Val Cys Gln Val Cys Gln Tyr Arg Ser Ser Leu Tyr Ser Glu Val Asp 
    530                 535                 540                 


Val His Phe Arg Met Ile His Glu Asp Thr Arg His Leu Leu Cys Pro 
545                 550                 555                 560 


Tyr Cys Leu Lys Val Phe Lys Asn Gly Asn Ala Phe Gln Gln His Tyr 
                565                 570                 575     


Met Arg His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys Arg Leu 
            580                 585                 590         


Gln Phe Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln His His 
        595                 600                 605             


Lys Thr Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro Gly Thr 
    610                 615                 620                 


Lys Val Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val Pro Val 
625                 630                 635                 640 


Ser Ser Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala Pro Leu 
                645                 650                 655     


Thr Ser Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro Val Gln 
            660                 665                 670         


Arg Ser Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met Gly Arg 
        675                 680                 685             


Gln Thr Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro Asn His 
    690                 695                 700                 


Phe Pro Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr Cys Cys 
705                 710                 715                 720 


Ser Arg Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro Arg Lys 
                725                 730                 735     


Ser Pro Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly Ile Lys 
            740                 745                 750         


Leu Ala Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp Ala Met 
        755                 760                 765             


Ala Lys His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser Ile Leu 
    770                 775                 780                 


Pro Arg Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln Thr Arg 
785                 790                 795                 800 


Asp Arg Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro Pro Ser 
                805                 810                 815     


Phe Pro Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala Thr Pro 
            820                 825                 830         


Ala Glu Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu Pro Ser 
        835                 840                 845             


Pro Ala Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro Gln Ala 
    850                 855                 860                 


Leu Ala Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu Asn Val 
865                 870                 875                 880 


Asp Asp Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu Leu Ala 
                885                 890                 895     


Ser Gly Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln Leu Ser 
            900                 905                 910         


Val Lys Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn Thr Glu 
        915                 920                 925             


Gln Ala Ala Glu His Phe Arg Asn Pro Gln Arg Arg Ile Arg Arg Trp 
    930                 935                 940                 


Leu Arg Arg Phe Gln Ala Ser Gln Gly Glu Asn Leu Glu Gly Lys Tyr 
945                 950                 955                 960 


Leu Ser Phe Glu Ala Glu Glu Lys Leu Ala Glu Trp Val Leu Thr Gln 
                965                 970                 975     


Arg Glu Gln Gln Leu Pro Val Asn Glu Glu Thr Leu Phe Gln Lys Ala 
            980                 985                 990         


Thr Lys Ile Gly Arg Ser Leu Glu  Gly Gly Phe Lys Ile  Ser Tyr Glu 
        995                 1000                 1005             


Trp Ala  Val Arg Phe Met Leu  Arg His His Leu Thr  Pro His Ala 
    1010                 1015                 1020             


Arg Arg  Ala Val Ala His Thr  Leu Pro Lys Asp Val  Ala Glu Asn 
    1025                 1030                 1035             


Ala Gly  Leu Phe Ile Asp Phe  Val Gln Arg Gln Ile  His Asn Gln 
    1040                 1045                 1050             


Asp Leu  Pro Leu Ser Met Ile  Val Ala Ile Asp Glu  Ile Ser Leu 
    1055                 1060                 1065             


Phe Leu  Asp Thr Glu Val Leu  Ser Ser Asp Asp Arg  Lys Glu Asn 
    1070                 1075                 1080             


Ala Leu  Gln Thr Val Gly Thr  Gly Glu Pro Trp Cys  Asp Val Val 
    1085                 1090                 1095             


Leu Ala  Ile Leu Ala Asp Gly  Thr Val Leu Pro Thr  Leu Val Phe 
    1100                 1105                 1110             


Tyr Arg  Gly Gln Met Asp Gln  Pro Ala Asn Met Pro  Asp Ser Ile 
    1115                 1120                 1125             


Leu Leu  Glu Ala Lys Glu Ser  Gly Tyr Ser Asp Asp  Glu Ile Met 
    1130                 1135                 1140             


Glu Leu  Trp Ser Thr Arg Val  Trp Gln Lys His Thr  Ala Cys Gln 
    1145                 1150                 1155             


Arg Ser  Lys Gly Met Leu Val  Met Asp Cys His Arg  Thr His Leu 
    1160                 1165                 1170             


Ser Glu  Glu Val Leu Ala Met  Leu Ser Ala Ser Ser  Thr Leu Pro 
    1175                 1180                 1185             


Ala Val  Val Pro Ala Gly Cys  Ser Ser Lys Ile Gln  Pro Leu Asp 
    1190                 1195                 1200             


Val Cys  Ile Lys Arg Thr Val  Lys Asn Phe Leu His  Lys Lys Trp 
    1205                 1210                 1215             


Lys Glu  Gln Ala Arg Glu Met  Ala Asp Thr Ala Cys  Asp Ser Asp 
    1220                 1225                 1230             


Val Leu  Leu Gln Leu Val Leu  Val Trp Leu Gly Glu  Val Leu Gly 
    1235                 1240                 1245             


Val Ile  Gly Asp Cys Pro Glu  Leu Val Gln Arg Ser  Phe Leu Val 
    1250                 1255                 1260             


Ala Ser  Val Leu Pro Gly Pro  Asp Gly Asn Ile Asn  Ser Pro Thr 
    1265                 1270                 1275             


Arg Asn  Ala Asp Met Gln Glu  Glu Leu Ile Ala Ser  Leu Glu Glu 
    1280                 1285                 1290             


Gln Leu  Lys Leu Ser Gly Glu  His Ser Glu Ser Ser  Thr Pro Arg 
    1295                 1300                 1305             


Pro Arg  Ser Ser Pro Glu Glu  Thr Ile Glu Pro Glu  Ser Leu His 
    1310                 1315                 1320             


Gln Leu  Phe Glu Gly Glu Ser  Glu Thr Glu Ser Phe  Tyr Gly Phe 
    1325                 1330                 1335             


Glu Glu  Ala Asp Leu Asp Leu  Met Glu Ile 
    1340                 1345             


<210> 8626
<211> 186
<212> PRT
<213> Homo sapiens

<400> 8626
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala Gln Asn Arg Lys Leu Ile Glu Phe Leu 
        35                  40                  45              


Leu Lys Ala Glu Cys Leu Glu Asp Leu Val Ser Phe Ile Ile Glu Glu 
    50                  55                  60                  


Pro Pro Gln Asp Met Asp Glu Lys Ile Arg Tyr Lys Tyr Pro Asn Ile 
65                  70                  75                  80  


Ser Cys Glu Leu Leu Thr Ser Asp Val Ser Gln Met Asn Asp Arg Leu 
                85                  90                  95      


Gly Glu Asp Glu Ser Leu Leu Met Lys Leu Tyr Ser Phe Leu Leu Asn 
            100                 105                 110         


Asp Ser Pro Leu Asn Pro Leu Leu Ala Ser Phe Phe Ser Lys Val Leu 
        115                 120                 125             


Ser Ile Leu Ile Ser Arg Lys Pro Glu Gln Ile Val Asp Phe Leu Lys 
    130                 135                 140                 


Lys Lys His Asp Phe Val Asp Leu Ile Ile Lys His Ile Gly Thr Ser 
145                 150                 155                 160 


Ala Ile Met Asp Leu Leu Leu Arg Leu Leu Thr Cys Ile Glu Pro Pro 
                165                 170                 175     


Gln Pro Arg Gln Asp Val Leu Asn Trp Leu 
            180                 185     


<210> 8627
<211> 95
<212> PRT
<213> Homo sapiens

<400> 8627
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val Gln 
65                  70                  75                  80  


Leu Ser Ser Lys Glu Lys Ile Trp Thr Gln Glu Met Leu Leu Gln 
                85                  90                  95  


<210> 8628
<211> 579
<212> PRT
<213> Homo sapiens

<400> 8628
Met Asp Asp Ser Lys Gln Glu Ser Thr Thr Ser Lys Glu Glu Glu Thr 
1               5                   10                  15      


Asn Ile Ile Ser Ser Ile Val Pro Ser Thr Gln Asp Ile Tyr Gln Arg 
            20                  25                  30          


Gln Asn Ser Ser Asp Val His Lys Ser Leu Leu Pro Ala Val Asp Glu 
        35                  40                  45              


Thr Thr Cys Gly His Thr His Phe Gln Gln Met Ile Asp Lys Tyr Ile 
    50                  55                  60                  


Asn Glu Ala Asn Leu Ile Pro Glu Lys Thr Asp Leu Gln Glu Leu Glu 
65                  70                  75                  80  


His Ile Phe Pro Asn Leu His His Gln Leu Phe Lys Pro Leu Glu Pro 
                85                  90                  95      


His Pro Asp Phe Asp Leu Ser Ser Ser Ser Ser Gly Ile Ser Pro Asp 
            100                 105                 110         


Asn Arg Asp Phe Tyr Gln Arg Ser Asp Ser Ser Ser Glu Ser His Cys 
        115                 120                 125             


Ala Thr Gly Leu Ser Lys Ser Thr Val Tyr Phe Thr Ala Leu Arg Arg 
    130                 135                 140                 


Thr Ser Met His Ser Ser Leu Asn Thr Ser Pro Asn Gln Gln Pro Asp 
145                 150                 155                 160 


Thr Asn Leu Ala His Val Gly Ala His Ser Phe Ala Thr Glu Asn Ile 
                165                 170                 175     


Ile Gly Gly Ser Glu Gln Cys Phe Glu Gln Leu Gln Pro Glu Tyr Ser 
            180                 185                 190         


Ser Gln Glu Glu Ser Gln His Ala Asp Leu Pro Ser Ile Phe Ser Ile 
        195                 200                 205             


Glu Ala Arg Asp Ser Ser Gln Gly Met Lys Asn Gln Asn Tyr Pro Ser 
    210                 215                 220                 


Glu Glu His Thr Glu Ile Leu Gln Asn Lys Lys Lys Ile Val His Phe 
225                 230                 235                 240 


Gln Leu Ser Ile Gly Asn Leu Ser Ser Val Tyr Ser Ser Ser Asp Glu 
                245                 250                 255     


Ala Asn Val Phe Asp Gln Leu Asn Val Gln His Ser Thr Pro Cys Gly 
            260                 265                 270         


Ser Asn Ser Ser Glu Cys Ser Thr Lys His Gln Leu Glu Ser Arg Lys 
        275                 280                 285             


Glu Ser Met Gly Phe Glu Glu Leu Ser Lys Arg Gly Val Val Thr Met 
    290                 295                 300                 


Leu Gln Ser Gln Gly Leu Ile Glu Asp Asn Lys Asn Glu Thr Cys Arg 
305                 310                 315                 320 


Val Leu Asp Ile Asn Pro Gln Val Glu Glu Thr Asp Ser Arg Leu Cys 
                325                 330                 335     


Val Arg Thr Val Glu Met Gly Thr Ser Ile Gln Ala Pro Tyr Ser Leu 
            340                 345                 350         


Thr Thr Gln Asn Glu Lys Tyr Phe Glu Asn Ser Ala Glu Thr Asp Ile 
        355                 360                 365             


Pro Lys Ile Thr Lys Lys Leu Ser Gln Leu Gly Glu Ser Glu Leu Phe 
    370                 375                 380                 


Ala Ser Ser Gly Ser Phe Ser Leu Gln Ser Ser Ile Pro Val Trp Glu 
385                 390                 395                 400 


Thr Glu Thr Gly His Gly Ile Met Glu Glu Pro Glu Leu Thr Leu Ile 
                405                 410                 415     


Ser Thr Thr Asp Thr Ser Ile Ala Glu Met Asp Phe Ala Asn Leu Thr 
            420                 425                 430         


Leu Glu Glu Lys Ser Glu Asn Glu Ala Lys Cys Phe Phe Gln Val Ser 
        435                 440                 445             


Glu Phe Leu Pro Leu Val Ser Ala Thr Glu Ala Ser Asp Tyr Pro Ala 
    450                 455                 460                 


Val Ser Glu Leu Ser Ile Glu Lys Pro Arg Thr Ala Ser Thr Ala Glu 
465                 470                 475                 480 


Thr Pro Arg Arg Leu Thr Pro Val Pro Gly Ser Leu Gln Glu Ala Phe 
                485                 490                 495     


Ile Lys Arg Lys Lys Ser Phe Met Glu Arg Ser His Gln Arg Gln Lys 
            500                 505                 510         


Glu Ile Arg Asn Lys Ile His Val Ser Glu Asn Ser Gln Ile Lys Thr 
        515                 520                 525             


Val Lys Glu Lys Pro Ser Ile Ser Ser Ser Val Ser Arg Leu Lys Gly 
    530                 535                 540                 


Val Asn Lys Val Arg Ala Ser Phe Pro Glu Asp Arg Lys Thr Thr Gln 
545                 550                 555                 560 


Ala Leu Arg His Gln Arg Gly Leu Arg Leu Tyr Asn Gln Leu Ala Glu 
                565                 570                 575     


Val Lys Gln 
            


<210> 8629
<211> 144
<212> PRT
<213> Homo sapiens

<400> 8629
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu 
                85                  90                  95      


Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu 
            100                 105                 110         


Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser 
        115                 120                 125             


Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser Glu 
    130                 135                 140                 


<210> 8630
<211> 81
<212> PRT
<213> Homo sapiens

<400> 8630
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg 
    


<210> 8631
<211> 512
<212> PRT
<213> Homo sapiens

<400> 8631
Met Ala Ala Phe Lys Leu Asp Phe Leu Pro Glu Met Met Val Asp His 
1               5                   10                  15      


Cys Ser Leu Asn Ser Ser Pro Val Ser Lys Lys Met Asn Gly Thr Leu 
            20                  25                  30          


Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile Lys Met Phe Val Gly 
        35                  40                  45              


Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu Arg Glu Leu Phe Glu 
    50                  55                  60                  


Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu Arg Asp Arg Ser Gln 
65                  70                  75                  80  


Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val Thr Phe Tyr Thr Arg 
                85                  90                  95      


Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His Asn Met Lys Val Leu 
            100                 105                 110         


Pro Gly Met His His Pro Ile Gln Met Lys Pro Ala Asp Ser Glu Lys 
        115                 120                 125             


Asn Asn Val Glu Asp Arg Lys Leu Phe Ile Gly Met Ile Ser Lys Lys 
    130                 135                 140                 


Cys Thr Glu Asn Asp Ile Arg Val Met Phe Ser Ser Phe Gly Gln Ile 
145                 150                 155                 160 


Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp Gly Leu Ser Arg Gly Cys 
                165                 170                 175     


Ala Phe Val Thr Phe Thr Thr Arg Ala Met Ala Gln Thr Ala Ile Lys 
            180                 185                 190         


Ala Met His Gln Ala Gln Thr Met Glu Gly Cys Ser Ser Pro Met Val 
        195                 200                 205             


Val Lys Phe Ala Asp Thr Gln Lys Asp Lys Glu Gln Lys Arg Met Ala 
    210                 215                 220                 


Gln Gln Leu Gln Gln Gln Met Gln Gln Ile Ser Ala Ala Ser Val Trp 
225                 230                 235                 240 


Gly Asn Leu Ala Gly Leu Asn Thr Leu Gly Pro Gln Tyr Leu Ala Leu 
                245                 250                 255     


Tyr Leu Gln Leu Leu Gln Gln Thr Ala Ser Ser Gly Asn Leu Asn Thr 
            260                 265                 270         


Leu Ser Ser Leu His Pro Met Gly Gly Leu Asn Ala Met Gln Leu Gln 
        275                 280                 285             


Asn Leu Ala Ala Leu Ala Ala Ala Ala Ser Ala Ala Gln Asn Thr Pro 
    290                 295                 300                 


Ser Gly Thr Asn Ala Leu Thr Thr Ser Ser Ser Pro Leu Ser Val Leu 
305                 310                 315                 320 


Thr Ser Ser Gly Ser Ser Pro Ser Ser Ser Ser Ser Asn Ser Val Asn 
                325                 330                 335     


Pro Ile Ala Ser Leu Gly Ala Leu Gln Thr Leu Ala Gly Ala Thr Ala 
            340                 345                 350         


Gly Leu Asn Val Gly Ser Leu Ala Gly Met Ala Ala Leu Asn Gly Gly 
        355                 360                 365             


Leu Gly Ser Ser Gly Leu Ser Asn Gly Thr Gly Ser Thr Met Glu Ala 
    370                 375                 380                 


Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu 
385                 390                 395                 400 


Pro Thr Leu Tyr Asn Gln Asn Leu Leu Thr Gln Gln Ser Ile Gly Ala 
                405                 410                 415     


Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr 
            420                 425                 430         


His Leu Pro Gln Glu Phe Gly Asp Gln Asp Leu Leu Gln Met Phe Met 
        435                 440                 445             


Pro Phe Gly Asn Val Val Ser Ala Lys Val Phe Ile Asp Lys Gln Thr 
    450                 455                 460                 


Asn Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro Val Ser 
465                 470                 475                 480 


Ala Gln Ala Ala Ile Gln Ser Met Asn Gly Phe Gln Ile Gly Met Lys 
                485                 490                 495     


Arg Leu Lys Val Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
            500                 505                 510         


<210> 8632
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8632
Met Lys Asp Val Pro Gly Phe Leu Gln Gln Ser Gln Asn Ser Gly Pro 
1               5                   10                  15      


Gly Gln Pro Ala Val Trp His Arg Leu Glu Glu Leu Tyr Thr Lys Lys 
            20                  25                  30          


Leu Trp His Gln Leu Thr Leu Gln Val Leu Asp Phe Val Gln Asp Pro 
        35                  40                  45              


Cys Phe Ala Gln Gly Asp Gly Leu Ile Lys Leu Tyr Glu Asn Phe Ile 
    50                  55                  60                  


Ser Glu Phe Glu His Arg Val Asn Pro Leu Ser Leu Val Glu Ile Ile 
65                  70                  75                  80  


Leu His Val Val Arg Gln Met Thr Asp Pro Asn Val Ala Leu Thr Phe 
                85                  90                  95      


Leu Glu Lys Thr Arg Glu Lys Val Lys Ser Ser Asp Glu Ala Val Ile 
            100                 105                 110         


Leu Cys Lys Thr Ala Ile Gly Ala Leu Lys Leu Asn Ile Gly Asp Leu 
        115                 120                 125             


Gln Val Thr Lys Glu Thr Ile Glu Asp Val Glu Glu Met Leu Asn Asn 
    130                 135                 140                 


Leu Pro Gly Val Thr Ser Val His Ser Arg Phe Tyr Asp Leu Ser Ser 
145                 150                 155                 160 


Lys Tyr Tyr Gln Thr Ile Gly Asn His Ala Ser Tyr Tyr Lys Asp Ala 
                165                 170                 175     


Leu Arg Phe Leu Gly Cys Val Asp Ile Lys Asp Leu Pro Val Ser Glu 
            180                 185                 190         


Gln Gln Glu Arg Ala Phe Thr Leu Gly Leu Ala Gly Leu Leu Gly Glu 
        195                 200                 205             


Gly Val Phe Asn Phe Gly Glu Leu Leu Met His Pro Val Leu Glu Ser 
    210                 215                 220                 


Leu Arg Asn Thr Asp Arg Gln Trp Leu Ile Asp Thr Leu Tyr Ala Phe 
225                 230                 235                 240 


Asn Ser Gly Asn Val Glu Arg Phe Gln Thr Leu Lys Thr Ala Trp Gly 
                245                 250                 255     


Gln Gln Pro Asp Leu Ala Ala Asn Glu Ala Gln Leu Leu Arg Lys Ile 
            260                 265                 270         


Gln Leu Leu Cys Leu Met Glu Met Thr Phe Thr Arg Pro Ala Asn His 
        275                 280                 285             


Arg Gln Leu Thr Phe Glu Glu Ile Ala Lys Ser Ala Lys Ile Thr Val 
    290                 295                 300                 


Asn Glu Val Glu Leu Leu Val Met Lys Ala Leu Ser Val Gly Leu Val 
305                 310                 315                 320 


Lys Gly Ser Ile Asp Glu Val Asp Lys Arg Val His Met Thr Trp Val 
                325                 330                 335     


Gln Pro Arg Val Leu Asp Leu Gln Gln Ile Lys Gly Met Lys Asp Arg 
            340                 345                 350         


Leu Glu Phe Trp Cys Thr Asp Val Lys Ser Met Glu Met Leu Val Glu 
        355                 360                 365             


His Gln Ala His Asp Ile Leu Thr 
    370                 375     


<210> 8633
<211> 162
<212> PRT
<213> Homo sapiens

<400> 8633
Met Thr Ser Lys Lys Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp 
1               5                   10                  15      


Ala Leu Ala Gly Leu Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln 
            20                  25                  30          


Gly His Arg Val Ala Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg 
        35                  40                  45              


Val Ala Leu Leu Ser Gly Gly Gly Ser Gly His Glu Pro Ala His Ala 
    50                  55                  60                  


Gly Phe Ile Gly Lys Gly Met Leu Thr Gly Val Ile Ala Gly Ala Val 
65                  70                  75                  80  


Phe Thr Ser Pro Ala Val Gly Ser Ile Leu Ala Ala Ile Arg Ala Val 
                85                  90                  95      


Ala Gln Ala Gly Thr Val Gly Thr Leu Leu Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Arg Leu Asn Phe Gly Leu Ala Arg Glu Gln Ala Arg Ala Glu 
        115                 120                 125             


Gly Ile Pro Val Glu Met Val Val Ile Gly Asp Asp Ser Ala Phe Thr 
    130                 135                 140                 


Val Leu Lys Lys Ala Gly Arg Arg Gly Leu Cys Gly Thr Val Leu Ile 
145                 150                 155                 160 


His Lys 
        


<210> 8634
<211> 2617
<212> PRT
<213> Homo sapiens

<400> 8634
Met Leu Thr Asp Ser Gly Gly Gly Gly Thr Ser Phe Glu Glu Asp Leu 
1               5                   10                  15      


Asp Ser Val Ala Pro Arg Ser Ala Pro Ala Gly Ala Ser Glu Pro Pro 
            20                  25                  30          


Pro Pro Gly Gly Val Gly Leu Gly Ile Arg Thr Val Arg Leu Phe Gly 
        35                  40                  45              


Glu Ala Gly Pro Ala Ser Gly Val Gly Ser Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Gly Gly Gly Asp Ala Ala Leu Asp Phe Lys Leu Ala 
65                  70                  75                  80  


Ala Ala Val Leu Arg Thr Gly Gly Gly Gly Gly Ala Ser Gly Ser Asp 
                85                  90                  95      


Glu Asp Glu Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Glu Asp 
            100                 105                 110         


Leu Asp Asn Pro Val Leu Lys Thr Thr Ser Glu Ile Phe Leu Ser Ser 
        115                 120                 125             


Thr Ala Glu Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala 
    130                 135                 140                 


Arg Leu Glu Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr 
145                 150                 155                 160 


Ala Asp Gly Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr 
                165                 170                 175     


Ser Ser Val Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg 
            180                 185                 190         


Met Lys Ala Glu Asn Ser His Asn Ala Gly Gln Val Asp Thr Arg Ser 
        195                 200                 205             


Leu Ala Glu Ala Cys Ser Asp Gly Asp Val Asn Ala Val Arg Lys Leu 
    210                 215                 220                 


Leu Asp Glu Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser 
225                 230                 235                 240 


Leu Leu Cys Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val 
                245                 250                 255     


Leu Leu Ala Met His Ala Asn Val Glu Asp Arg Gly Asn Lys Gly Asp 
            260                 265                 270         


Ile Thr Pro Leu Met Ala Ala Ser Ser Gly Gly Tyr Leu Asp Ile Val 
        275                 280                 285             


Lys Leu Leu Leu Leu His Asp Ala Asp Val Asn Ser Gln Ser Ala Thr 
    290                 295                 300                 


Gly Asn Thr Ala Leu Thr Tyr Ala Cys Ala Gly Gly Phe Val Asp Ile 
305                 310                 315                 320 


Val Lys Val Leu Leu Asn Glu Gly Ala Asn Ile Glu Asp His Asn Glu 
                325                 330                 335     


Asn Gly His Thr Pro Leu Met Glu Ala Ala Ser Ala Gly His Val Glu 
            340                 345                 350         


Val Ala Arg Val Leu Leu Asp His Gly Ala Gly Ile Asn Thr His Ser 
        355                 360                 365             


Asn Glu Phe Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His 
    370                 375                 380                 


Leu Asp Met Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His 
385                 390                 395                 400 


Lys Thr Asp Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly 
                405                 410                 415     


His Val Glu Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn 
            420                 425                 430         


Met Pro Ala Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly 
        435                 440                 445             


Gly His Val Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Asn Leu 
    450                 455                 460                 


Glu Glu Val Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg 
465                 470                 475                 480 


Glu Gly His Glu Glu Met Val Ala Leu Leu Leu Ala Gln Gly Ala Asn 
                485                 490                 495     


Ile Asn Ala Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala 
            500                 505                 510         


Cys Cys Gly Gly Phe Ser Glu Val Ala Asp Phe Leu Ile Lys Ala Gly 
        515                 520                 525             


Ala Asp Ile Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ser Gln 
    530                 535                 540                 


Glu Gly His Leu Glu Leu Val Lys Tyr Leu Leu Ala Ser Gly Ala Asn 
545                 550                 555                 560 


Val His Ala Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys 
                565                 570                 575     


Glu Asn Gly His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala 
            580                 585                 590         


Asp Leu Glu His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala 
        595                 600                 605             


Ala Arg Ala Gly His Leu Cys Thr Val Gln Phe Leu Ile Ser Lys Gly 
    610                 615                 620                 


Ala Asn Val Asn Arg Ala Thr Ala Asn Asn Asp His Thr Val Val Ser 
625                 630                 635                 640 


Leu Ala Cys Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala 
                645                 650                 655     


His Gly Ala Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu 
            660                 665                 670         


Ile Glu Ala Ala Lys Gly Gly His Thr Asn Val Val Ser Tyr Leu Leu 
        675                 680                 685             


Asp Tyr Pro Asn Asn Val Leu Ser Val Pro Thr Thr Asp Val Ser Gln 
    690                 695                 700                 


Leu Pro Pro Pro Ser Gln Asp Gln Ser Gln Val Pro Arg Val Pro Thr 
705                 710                 715                 720 


His Thr Leu Ala Met Val Val Pro Pro Gln Glu Pro Asp Arg Thr Ser 
                725                 730                 735     


Gln Glu Asn Ser Pro Ala Leu Leu Gly Val Gln Lys Gly Thr Ser Lys 
            740                 745                 750         


Gln Lys Ser Ser Ser Leu Gln Val Ala Asp Gln Asp Leu Leu Pro Ser 
        755                 760                 765             


Phe His Pro Tyr Gln Pro Leu Glu Cys Ile Val Glu Glu Thr Glu Gly 
    770                 775                 780                 


Lys Leu Asn Glu Leu Gly Gln Arg Ile Ser Ala Ile Glu Lys Ala Gln 
785                 790                 795                 800 


Leu Lys Ser Leu Glu Leu Ile Gln Gly Glu Pro Leu Asn Lys Asp Lys 
                805                 810                 815     


Ile Glu Glu Leu Lys Lys Asn Arg Glu Glu Gln Val Gln Lys Lys Lys 
            820                 825                 830         


Lys Ile Leu Lys Glu Leu Gln Lys Val Glu Arg Gln Leu Gln Met Lys 
        835                 840                 845             


Thr Gln Gln Gln Phe Thr Lys Glu Tyr Leu Glu Thr Lys Gly Gln Lys 
    850                 855                 860                 


Asp Thr Val Ser Leu His Gln Gln Cys Ser His Arg Gly Val Phe Pro 
865                 870                 875                 880 


Glu Gly Glu Gly Asp Gly Ser Leu Pro Glu Asp His Phe Ser Glu Leu 
                885                 890                 895     


Pro Gln Val Asp Thr Ile Leu Phe Lys Asp Asn Asp Val Asp Asp Glu 
            900                 905                 910         


Gln Gln Ser Pro Pro Ser Ala Glu Gln Ile Asp Phe Val Pro Val Gln 
        915                 920                 925             


Pro Leu Ser Ser Pro Gln Cys Asn Phe Ser Ser Asp Leu Gly Ser Asn 
    930                 935                 940                 


Gly Thr Asn Ser Leu Glu Leu Gln Lys Val Ser Gly Asn Gln Gln Ile 
945                 950                 955                 960 


Val Gly Gln Pro Gln Ile Ala Ile Thr Gly His Asp Gln Gly Leu Leu 
                965                 970                 975     


Val Gln Glu Pro Asp Gly Leu Met Val Ala Thr Pro Ala Gln Thr Leu 
            980                 985                 990         


Thr Asp Thr Leu Asp Asp Leu Ile  Ala Ala Val Ser Thr  Arg Val Pro 
        995                 1000                 1005             


Thr Gly  Ser Asn Ser Ser Ser  Gln Thr Thr Glu Cys  Leu Thr Pro 
    1010                 1015                 1020             


Glu Ser  Cys Ser Gln Thr Thr  Ser Asn Val Ala Ser  Gln Ser Met 
    1025                 1030                 1035             


Pro Pro  Val Tyr Pro Ser Val  Asp Ile Asp Ala His  Thr Glu Ser 
    1040                 1045                 1050             


Asn His  Asp Thr Ala Leu Thr  Leu Ala Cys Ala Gly  Gly His Glu 
    1055                 1060                 1065             


Glu Leu  Val Ser Val Leu Ile  Ala Arg Asp Ala Lys  Ile Glu His 
    1070                 1075                 1080             


Arg Asp  Lys Lys Gly Phe Thr  Pro Leu Ile Leu Ala  Ala Thr Ala 
    1085                 1090                 1095             


Gly His  Val Gly Val Val Glu  Ile Leu Leu Asp Lys  Gly Gly Asp 
    1100                 1105                 1110             


Ile Glu  Ala Gln Ser Glu Arg  Thr Lys Asp Thr Pro  Leu Ser Leu 
    1115                 1120                 1125             


Ala Cys  Ser Gly Gly Arg Gln  Glu Val Val Asp Leu  Leu Leu Ala 
    1130                 1135                 1140             


Arg Gly  Ala Asn Lys Glu His  Arg Asn Val Ser Asp  Tyr Thr Pro 
    1145                 1150                 1155             


Leu Ser  Leu Ala Ala Ser Gly  Gly Tyr Val Asn Ile  Ile Lys Ile 
    1160                 1165                 1170             


Leu Leu  Asn Ala Gly Ala Glu  Ile Asn Ser Arg Thr  Gly Ser Lys 
    1175                 1180                 1185             


Leu Gly  Ile Ser Pro Leu Met  Leu Ala Ala Met Asn  Gly His Val 
    1190                 1195                 1200             


Pro Ala  Val Lys Leu Leu Leu  Asp Met Gly Ser Asp  Ile Asn Ala 
    1205                 1210                 1215             


Gln Ile  Glu Thr Asn Arg Asn  Thr Ala Leu Thr Leu  Ala Cys Phe 
    1220                 1225                 1230             


Gln Gly  Arg Ala Glu Val Val  Ser Leu Leu Leu Asp  Arg Lys Ala 
    1235                 1240                 1245             


Asn Val  Glu His Arg Ala Lys  Thr Gly Leu Thr Pro  Leu Met Glu 
    1250                 1255                 1260             


Ala Ala  Ser Gly Gly Tyr Ala  Glu Val Gly Arg Val  Leu Leu Asp 
    1265                 1270                 1275             


Lys Gly  Ala Asp Val Asn Ala  Pro Pro Val Pro Ser  Ser Arg Asp 
    1280                 1285                 1290             


Thr Ala  Leu Thr Ile Ala Ala  Asp Lys Gly His Tyr  Lys Phe Cys 
    1295                 1300                 1305             


Glu Leu  Leu Ile His Arg Gly  Ala His Ile Asp Val  Arg Asn Lys 
    1310                 1315                 1320             


Lys Gly  Asn Thr Pro Leu Trp  Leu Ala Ser Asn Gly  Gly His Phe 
    1325                 1330                 1335             


Asp Val  Val Gln Leu Leu Val  Gln Ala Gly Ala Asp  Val Asp Ala 
    1340                 1345                 1350             


Ala Asp  Asn Arg Lys Ile Thr  Pro Leu Met Ser Ala  Phe Arg Lys 
    1355                 1360                 1365             


Gly His  Val Lys Val Val Gln  Tyr Leu Val Lys Glu  Val Asn Gln 
    1370                 1375                 1380             


Phe Pro  Ser Asp Ile Glu Cys  Met Arg Tyr Ile Ala  Thr Ile Thr 
    1385                 1390                 1395             


Asp Lys  Glu Leu Leu Lys Lys  Cys His Gln Cys Val  Glu Thr Ile 
    1400                 1405                 1410             


Val Lys  Ala Lys Asp Gln Gln  Ala Ala Glu Ala Asn  Lys Asn Ala 
    1415                 1420                 1425             


Ser Ile  Leu Leu Lys Glu Leu  Asp Leu Glu Lys Ser  Arg Glu Glu 
    1430                 1435                 1440             


Ser Arg  Lys Gln Ala Leu Ala  Ala Lys Arg Glu Lys  Arg Lys Glu 
    1445                 1450                 1455             


Lys Arg  Lys Lys Lys Lys Glu  Glu Gln Lys Arg Lys  Gln Glu Glu 
    1460                 1465                 1470             


Asp Glu  Glu Asn Lys Pro Lys  Glu Asn Ser Glu Leu  Pro Glu Asp 
    1475                 1480                 1485             


Glu Asp  Glu Glu Glu Asn Asp  Glu Asp Val Glu Gln  Glu Val Pro 
    1490                 1495                 1500             


Ile Glu  Pro Pro Ser Ala Thr  Thr Thr Thr Thr Ile  Gly Ile Ser 
    1505                 1510                 1515             


Ala Thr  Ser Ala Thr Phe Thr  Asn Val Phe Gly Lys  Lys Arg Ala 
    1520                 1525                 1530             


Asn Val  Val Thr Thr Pro Ser  Thr Asn Arg Lys Asn  Lys Lys Asn 
    1535                 1540                 1545             


Lys Thr  Lys Glu Thr Pro Pro  Thr Ala His Leu Ile  Leu Pro Glu 
    1550                 1555                 1560             


Gln His  Met Ser Leu Ala Gln  Gln Lys Ala Asp Lys  Asn Lys Ile 
    1565                 1570                 1575             


Asn Gly  Glu Pro Arg Gly Gly  Gly Ala Gly Gly Asn  Ser Asp Ser 
    1580                 1585                 1590             


Asp Asn  Leu Asp Ser Thr Asp  Cys Asn Ser Glu Ser  Ser Ser Gly 
    1595                 1600                 1605             


Gly Lys  Ser Gln Glu Leu Asn  Phe Val Met Asp Val  Asn Ser Ser 
    1610                 1615                 1620             


Lys Tyr  Pro Ser Leu Leu Leu  His Ser Gln Glu Glu  Lys Thr Ser 
    1625                 1630                 1635             


Thr Ala  Thr Ser Lys Thr Gln  Thr Arg Leu Glu Gly  Glu Val Thr 
    1640                 1645                 1650             


Pro Asn  Ser Leu Ser Thr Ser  Tyr Lys Thr Val Ser  Leu Pro Leu 
    1655                 1660                 1665             


Ser Ser  Pro Asn Ile Lys Leu  Asn Leu Thr Ser Pro  Lys Arg Gly 
    1670                 1675                 1680             


Gln Lys  Arg Glu Glu Gly Trp  Lys Glu Val Val Arg  Arg Ser Lys 
    1685                 1690                 1695             


Lys Leu  Ser Val Pro Ala Ser  Val Val Ser Arg Ile  Met Gly Arg 
    1700                 1705                 1710             


Gly Gly  Cys Asn Ile Thr Ala  Ile Gln Asp Val Thr  Gly Ala His 
    1715                 1720                 1725             


Ile Asp  Val Asp Lys Gln Lys  Asp Lys Asn Gly Glu  Arg Met Ile 
    1730                 1735                 1740             


Thr Ile  Arg Gly Gly Thr Glu  Ser Thr Arg Tyr Ala  Val Gln Leu 
    1745                 1750                 1755             


Ile Asn  Ala Leu Ile Gln Asp  Pro Ala Lys Glu Leu  Glu Asp Leu 
    1760                 1765                 1770             


Ile Pro  Lys Asn His Ile Arg  Thr Pro Ala Ser Thr  Lys Ser Ile 
    1775                 1780                 1785             


His Ala  Asn Phe Ser Ser Gly  Val Gly Thr Thr Ala  Ala Ser Ser 
    1790                 1795                 1800             


Lys Asn  Ala Phe Pro Leu Gly  Ala Pro Thr Leu Val  Thr Ser Gln 
    1805                 1810                 1815             


Ala Thr  Thr Leu Ser Thr Phe  Gln Pro Ala Asn Lys  Leu Asn Lys 
    1820                 1825                 1830             


Asn Val  Pro Thr Asn Val Arg  Ser Ser Phe Pro Val  Ser Leu Pro 
    1835                 1840                 1845             


Leu Ala  Tyr Pro His Pro His  Phe Ala Leu Leu Ala  Ala Gln Thr 
    1850                 1855                 1860             


Met Gln  Gln Ile Arg His Pro  Arg Leu Pro Met Ala  Gln Phe Gly 
    1865                 1870                 1875             


Gly Thr  Phe Ser Pro Ser Pro  Asn Thr Trp Gly Pro  Phe Pro Val 
    1880                 1885                 1890             


Arg Pro  Val Asn Pro Gly Asn  Thr Asn Ser Ser Pro  Lys His Asn 
    1895                 1900                 1905             


Asn Thr  Ser Arg Leu Pro Asn  Gln Asn Gly Thr Val  Leu Pro Ser 
    1910                 1915                 1920             


Glu Ser  Ala Gly Leu Ala Thr  Ala Ser Cys Pro Ile  Thr Val Ser 
    1925                 1930                 1935             


Ser Val  Val Ala Ala Ser Gln  Gln Leu Cys Val Thr  Asn Thr Arg 
    1940                 1945                 1950             


Thr Pro  Ser Ser Val Arg Lys  Gln Leu Phe Ala Cys  Val Pro Lys 
    1955                 1960                 1965             


Thr Ser  Pro Pro Ala Thr Val  Ile Ser Ser Val Thr  Ser Thr Cys 
    1970                 1975                 1980             


Ser Ser  Leu Pro Ser Val Ser  Ser Ala Pro Ile Thr  Ser Gly Gln 
    1985                 1990                 1995             


Ala Pro  Thr Thr Phe Leu Pro  Ala Ser Thr Ser Gln  Ala Gln Leu 
    2000                 2005                 2010             


Ser Ser  Gln Lys Met Glu Ser  Phe Ser Ala Val Pro  Pro Thr Lys 
    2015                 2020                 2025             


Glu Lys  Val Ser Thr Gln Asp  Gln Pro Met Ala Asn  Leu Cys Thr 
    2030                 2035                 2040             


Pro Ser  Ser Thr Ala Asn Ser  Cys Ser Ser Ser Ala  Ser Asn Thr 
    2045                 2050                 2055             


Pro Gly  Ala Pro Glu Thr His  Pro Ser Ser Ser Pro  Thr Pro Thr 
    2060                 2065                 2070             


Ser Ser  Asn Thr Gln Glu Glu  Ala Gln Pro Ser Ser  Val Ser Asp 
    2075                 2080                 2085             


Leu Ser  Pro Met Ser Met Pro  Phe Ala Ser Asn Ser  Glu Pro Ala 
    2090                 2095                 2100             


Pro Leu  Thr Leu Thr Ser Pro  Arg Met Val Ala Ala  Asp Asn Gln 
    2105                 2110                 2115             


Asp Thr  Ser Asn Leu Pro Gln  Leu Ala Val Pro Ala  Pro Arg Val 
    2120                 2125                 2130             


Ser His  Arg Met Gln Pro Arg  Gly Ser Phe Tyr Ser  Met Val Pro 
    2135                 2140                 2145             


Asn Ala  Thr Ile His Gln Asp  Pro Gln Ser Ile Phe  Val Thr Asn 
    2150                 2155                 2160             


Pro Val  Thr Leu Thr Pro Pro  Gln Gly Pro Pro Ala  Ala Val Gln 
    2165                 2170                 2175             


Leu Ser  Ser Ala Val Asn Ile  Met Asn Gly Ser Gln  Met His Ile 
    2180                 2185                 2190             


Asn Pro  Ala Asn Lys Ser Leu  Pro Pro Thr Phe Gly  Pro Ala Thr 
    2195                 2200                 2205             


Leu Phe  Asn His Phe Ser Ser  Leu Phe Asp Ser Ser  Gln Val Pro 
    2210                 2215                 2220             


Ala Asn  Gln Gly Trp Gly Asp  Gly Pro Leu Ser Ser  Arg Val Ala 
    2225                 2230                 2235             


Thr Asp  Ala Ser Phe Thr Val  Gln Ser Ala Phe Leu  Gly Asn Ser 
    2240                 2245                 2250             


Val Leu  Gly His Leu Glu Asn  Met His Pro Asp Asn  Ser Lys Ala 
    2255                 2260                 2265             


Pro Gly  Phe Arg Pro Pro Ser  Gln Arg Val Ser Thr  Ser Pro Val 
    2270                 2275                 2280             


Gly Leu  Pro Ser Ile Asp Pro  Ser Gly Ser Ser Pro  Ser Ser Ser 
    2285                 2290                 2295             


Ser Ala  Pro Leu Ala Ser Phe  Ser Gly Ile Pro Gly  Thr Arg Val 
    2300                 2305                 2310             


Phe Leu  Gln Gly Pro Ala Pro  Val Gly Thr Pro Ser  Phe Asn Arg 
    2315                 2320                 2325             


Gln His  Phe Ser Pro His Pro  Trp Thr Ser Ala Ser  Asn Ser Ser 
    2330                 2335                 2340             


Thr Ser  Ala Pro Pro Thr Leu  Gly Gln Pro Lys Gly  Val Ser Ala 
    2345                 2350                 2355             


Ser Gln  Asp Arg Lys Ile Pro  Pro Pro Ile Gly Thr  Glu Arg Leu 
    2360                 2365                 2370             


Ala Arg  Ile Arg Gln Gly Gly  Ser Val Ala Gln Ala  Pro Ala Gly 
    2375                 2380                 2385             


Thr Ser  Phe Val Ala Pro Val  Gly His Ser Gly Ile  Trp Ser Phe 
    2390                 2395                 2400             


Gly Val  Asn Ala Val Ser Glu  Gly Leu Ser Gly Trp  Ser Gln Ser 
    2405                 2410                 2415             


Val Met  Gly Asn His Pro Met  His Gln Gln Leu Ser  Asp Pro Ser 
    2420                 2425                 2430             


Thr Phe  Ser Gln His Gln Pro  Met Glu Arg Asp Asp  Ser Gly Met 
    2435                 2440                 2445             


Val Ala  Pro Ser Asn Ile Phe  His Gln Pro Met Ala  Ser Gly Phe 
    2450                 2455                 2460             


Val Asp  Phe Ser Lys Gly Leu  Pro Ile Ser Met Tyr  Gly Gly Thr 
    2465                 2470                 2475             


Ile Ile  Pro Ser His Pro Gln  Leu Ala Asp Val Pro  Gly Gly Pro 
    2480                 2485                 2490             


Leu Phe  Asn Gly Leu His Asn  Pro Asp Pro Ala Trp  Asn Pro Met 
    2495                 2500                 2505             


Ile Lys  Val Ile Gln Asn Ser  Thr Glu Cys Thr Asp  Ala Gln Gln 
    2510                 2515                 2520             


Ala Ser  Leu Leu Pro Ser Val  Pro Ala Leu Lys Gly  Glu Ile Pro 
    2525                 2530                 2535             


Ser Pro  Gln Leu Thr Arg Pro  Lys Lys Arg Ile Gly  Arg Pro Met 
    2540                 2545                 2550             


Val Ala  Ser Pro Asn Gln Arg  His Gln Asp His Leu  Arg Pro Lys 
    2555                 2560                 2565             


Val Pro  Ala Gly Val Gln Glu  Leu Thr His Cys Pro  Asp Thr Pro 
    2570                 2575                 2580             


Leu Leu  Pro Pro Ser Asp Ser  Arg Gly His Asn Ser  Ser Asn Ser 
    2585                 2590                 2595             


Pro Ser  Leu Gln Ala Gly Gly  Ala Glu Gly Ala Gly  Asp Arg Gly 
    2600                 2605                 2610             


Arg Asp  Thr Arg 
    2615         


<210> 8635
<211> 250
<212> PRT
<213> Homo sapiens

<400> 8635
Met Gly Asp Ile Pro Ala Val Gly Leu Ser Ser Trp Lys Ala Ser Pro 
1               5                   10                  15      


Gly Lys Val Thr Glu Ala Val Lys Glu Ala Ile Asp Ala Gly Tyr Arg 
            20                  25                  30          


His Phe Asp Cys Ala Tyr Phe Tyr His Asn Glu Arg Glu Val Gly Ala 
        35                  40                  45              


Gly Ile Arg Cys Lys Ile Lys Glu Gly Ala Val Arg Arg Glu Asp Leu 
    50                  55                  60                  


Phe Ile Ala Thr Lys Leu Trp Cys Thr Cys His Lys Lys Ser Leu Val 
65                  70                  75                  80  


Glu Thr Ala Cys Arg Lys Ser Leu Lys Ala Leu Lys Leu Asn Tyr Leu 
                85                  90                  95      


Asp Leu Tyr Leu Ile His Trp Pro Met Gly Phe Lys Pro Pro His Pro 
            100                 105                 110         


Glu Trp Ile Met Ser Cys Ser Glu Leu Ser Phe Cys Leu Ser His Pro 
        115                 120                 125             


Arg Val Gln Asp Leu Pro Leu Asp Glu Ser Asn Met Val Ile Pro Ser 
    130                 135                 140                 


Asp Thr Asp Phe Leu Asp Thr Trp Glu Ala Met Glu Asp Leu Val Ile 
145                 150                 155                 160 


Thr Gly Leu Val Lys Asn Ile Gly Val Ser Asn Phe Asn His Glu Gln 
                165                 170                 175     


Leu Glu Arg Leu Leu Asn Lys Pro Gly Leu Arg Phe Lys Pro Leu Thr 
            180                 185                 190         


Asn Gln Ile Leu Ile Arg Phe Gln Ile Gln Arg Asn Val Ile Val Ile 
        195                 200                 205             


Pro Gly Ser Ile Thr Pro Ser His Ile Lys Glu Asn Ile Gln Val Phe 
    210                 215                 220                 


Asp Phe Glu Leu Thr Gln His Asp Met Asp Asn Ile Leu Ser Leu Asn 
225                 230                 235                 240 


Arg Asn Leu Arg Leu Ala Met Phe Pro Met 
                245                 250 


<210> 8636
<211> 174
<212> PRT
<213> Homo sapiens

<400> 8636
Met Leu Thr Glu Asn Gly Gln Val Leu Ser Cys Gly Ser Asn Ser Phe 
1               5                   10                  15      


Gly Gln Leu Gly Val Pro His Gly Pro Arg Arg Cys Val Val Pro Gln 
            20                  25                  30          


Ala Ile Glu Leu His Lys Glu Lys Val Val Cys Ile Ala Ala Gly Leu 
        35                  40                  45              


Arg His Ala Val Ala Ala Thr Ala Ser Gly Ile Val Phe Gln Trp Gly 
    50                  55                  60                  


Thr Gly Leu Ala Ser Cys Gly Arg Arg Leu Cys Pro Gly Gln Thr Leu 
65                  70                  75                  80  


Pro Leu Phe Phe Thr Ala Lys Glu Pro Ser Arg Val Thr Gly Leu Glu 
                85                  90                  95      


Asn Ser Lys Ala Met Cys Val Leu Ala Gly Ser Asp His Ser Ala Ser 
            100                 105                 110         


Leu Thr Asp Ala Gly Glu Val Tyr Val Trp Gly Ser Asn Lys His Gly 
        115                 120                 125             


Gln Leu Ala Asn Glu Ala Ala Phe Leu Pro Val Pro Gln Lys Ile Glu 
    130                 135                 140                 


Ala His Cys Phe Gln Asn Glu Lys Val Thr Ala Ile Trp Ser Gly Trp 
145                 150                 155                 160 


Thr His Leu Val Ala Gln Thr Gly Leu Leu Trp Leu Arg Ala 
                165                 170                 


<210> 8637
<211> 75
<212> PRT
<213> Homo sapiens

<400> 8637
Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe 
65                  70                  75  


<210> 8638
<211> 83
<212> PRT
<213> Homo sapiens

<400> 8638
Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu 
            20                  25                  30          


Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu 
        35                  40                  45              


Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg 
    50                  55                  60                  


Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Ala 
            


<210> 8639
<211> 175
<212> PRT
<213> Homo sapiens

<400> 8639
Met Leu Ser Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln 
1               5                   10                  15      


Leu Glu Asp Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu 
            20                  25                  30          


Arg His Leu Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn 
        35                  40                  45              


Glu Leu Lys Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr 
    50                  55                  60                  


Thr Ala Tyr Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys 
65                  70                  75                  80  


Ala Thr Ala Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe 
                85                  90                  95      


Gly Asp Met Ser Tyr Ser Ile Arg His Ser Ile Ser Met Pro Ala Met 
            100                 105                 110         


Arg Asn Ser Pro Thr Phe Lys Ser Phe Glu Glu Arg Val Glu Thr Thr 
        115                 120                 125             


Val Thr Ser Leu Lys Thr Lys Val Gly Gly Thr Asn Pro Asn Gly Gly 
    130                 135                 140                 


Ser Phe Glu Glu Val Leu Ser Ser Thr Ala His Ala Ser Ala Gln Ser 
145                 150                 155                 160 


Leu Ala Gly Gly Ser Arg Arg Thr Lys Glu Glu Glu Leu Gln Cys 
                165                 170                 175 


<210> 8640
<211> 76
<212> PRT
<213> Homo sapiens

<400> 8640
Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly 
65                  70                  75      


<210> 8641
<211> 151
<212> PRT
<213> Homo sapiens

<400> 8641
Met Ser Ile Pro Phe Ser Asn Thr His Tyr Arg Ile Pro Gln Gly Phe 
1               5                   10                  15      


Gly Asn Leu Leu Glu Gly Leu Thr Arg Glu Ile Leu Arg Glu Gln Pro 
            20                  25                  30          


Asp Asn Ile Pro Ala Phe Ala Ala Ala Tyr Phe Glu Ser Leu Leu Glu 
        35                  40                  45              


Lys Arg Glu Lys Thr Asn Phe Asp Pro Ala Glu Trp Gly Ser Lys Val 
    50                  55                  60                  


Glu Asp Arg Phe Tyr Asn Asn His Ala Phe Glu Glu Gln Glu Pro Pro 
65                  70                  75                  80  


Glu Lys Ser Asp Pro Lys Gln Glu Glu Ser Gln Ile Ser Gly Lys Glu 
                85                  90                  95      


Glu Glu Thr Ser Val Thr Ile Leu Asp Ser Ser Glu Glu Asp Lys Glu 
            100                 105                 110         


Lys Glu Glu Val Ala Ala Val Lys Ile Gln Ala Ala Phe Arg Gly His 
        115                 120                 125             


Ile Ala Arg Glu Glu Ala Lys Lys Met Lys Thr Asn Ser Leu Gln Asn 
    130                 135                 140                 


Glu Glu Lys Glu Glu Asn Lys 
145                 150     


<210> 8642
<211> 89
<212> PRT
<213> Homo sapiens

<400> 8642
Met Glu Ala Ala Asp Ala Ser Arg Ser Asn Gly Ser Ser Pro Glu Ala 
1               5                   10                  15      


Arg Asp Ala Arg Ser Pro Ser Gly Pro Ser Gly Ser Leu Glu Asn Gly 
            20                  25                  30          


Thr Lys Ala Asp Gly Lys Asp Ala Lys Thr Thr Asn Gly His Gly Gly 
        35                  40                  45              


Glu Ala Ala Glu Gly Lys Ser Leu Gly Ser Ala Leu Lys Pro Gly Glu 
    50                  55                  60                  


Gly Arg Ser Ala Leu Phe Ala Gly Asn Glu Trp Arg Arg Pro Ile Ile 
65                  70                  75                  80  


Gln Phe Val Glu Ser Gly Asp Asp Lys 
                85                  


<210> 8643
<211> 513
<212> PRT
<213> Homo sapiens

<400> 8643
Met Glu Val Gly Ile Thr Ile Gln His Ala Tyr Glu Lys Gln His Pro 
1               5                   10                  15      


Trp Ile Asp Leu Thr Ser Ile Gly Phe Ser Tyr Val Ile Asp Phe Asn 
            20                  25                  30          


Thr Met Gly Gln Ile Asn Arg Gln Thr Gln Arg Gln Arg Arg Val Arg 
        35                  40                  45              


Arg Arg Leu Asp Leu Ile Tyr Pro Met Val Thr Gly Thr Leu Pro Lys 
    50                  55                  60                  


Ala Gln Ser Trp Pro Val Ser Pro Gly Pro Ala Thr Ser Pro Pro Met 
65                  70                  75                  80  


Ser Pro Cys Ser Cys Pro Gln Cys Val Leu Val Met Ser Val Lys Ala 
                85                  90                  95      


Ala Val Val Asn Gly Ser Thr Gly Pro Leu Gln Leu Pro Val Thr Arg 
            100                 105                 110         


Lys Asn Met Pro Pro Pro Gly Val Val Lys Leu Pro Pro Leu Pro Gly 
        115                 120                 125             


Ser Gly Ala Lys Pro Leu Asp Ser Thr Gly Thr Ile Arg Gly Pro Leu 
    130                 135                 140                 


Lys Thr Ala Pro Ser Gln Val Ile Arg Arg Gln Ala Ser Ser Met Pro 
145                 150                 155                 160 


Thr Gly Thr Thr Met Gly Ser Pro Ala Ser Pro Pro Gly Pro Asn Ser 
                165                 170                 175     


Lys Thr Gly Arg Val Ala Leu Ala Thr Leu Asn Arg Thr Asn Leu Gln 
            180                 185                 190         


Arg Leu Ala Ile Ala Gln Ser Arg Val Leu Ile Ala Ser Gly Val Pro 
        195                 200                 205             


Thr Val Pro Val Lys Asn Leu Asn Gly Ser Ser Pro Val Asn Pro Ala 
    210                 215                 220                 


Leu Ala Gly Ile Thr Gly Ile Leu Met Ser Ala Ala Gly Leu Pro Val 
225                 230                 235                 240 


Cys Leu Thr Arg Pro Pro Lys Leu Val Leu His Pro Pro Pro Val Ser 
                245                 250                 255     


Lys Ser Glu Ile Lys Ser Ile Pro Gly Val Ser Asn Thr Ser Arg Lys 
            260                 265                 270         


Thr Thr Lys Lys Gln Ala Lys Lys Gly Lys Thr Pro Glu Glu Val Leu 
        275                 280                 285             


Lys Lys Tyr Leu Gln Lys Val Arg His Pro Pro Asp Glu Asp Cys Thr 
    290                 295                 300                 


Ile Cys Met Glu Arg Leu Thr Ala Pro Ser Gly Tyr Lys Gly Pro Gln 
305                 310                 315                 320 


Pro Thr Val Lys Pro Asp Leu Val Gly Lys Leu Ser Arg Cys Gly His 
                325                 330                 335     


Val Tyr His Ile Tyr Cys Leu Val Ala Met Tyr Asn Asn Gly Asn Lys 
            340                 345                 350         


Asp Gly Ser Leu Gln Cys Pro Thr Cys Lys Thr Ile Tyr Gly Val Lys 
        355                 360                 365             


Thr Gly Thr Gln Pro Pro Gly Lys Met Glu Tyr His Leu Ile Pro His 
    370                 375                 380                 


Ser Leu Pro Gly His Pro Asp Cys Lys Thr Ile Arg Ile Ile Tyr Ser 
385                 390                 395                 400 


Ile Pro Pro Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Ser 
                405                 410                 415     


Phe Ser Ala Arg Gly Phe Pro Arg His Cys Tyr Leu Pro Asp Ser Glu 
            420                 425                 430         


Lys Gly Arg Lys Val Leu Lys Leu Leu Leu Val Ala Trp Asp Arg Arg 
        435                 440                 445             


Leu Ile Phe Ala Ile Gly Thr Ser Ser Thr Thr Gly Glu Ser Asp Thr 
    450                 455                 460                 


Val Ile Trp Asn Glu Val His His Lys Thr Glu Phe Gly Ser Asn Leu 
465                 470                 475                 480 


Thr Gly His Gly Tyr Pro Asp Ala Asn Tyr Leu Asp Asn Val Leu Ala 
                485                 490                 495     


Glu Leu Ala Ala Gln Gly Ile Ser Glu Asp Ser Thr Ala Gln Glu Lys 
            500                 505                 510         


Asp 
    


<210> 8644
<211> 137
<212> PRT
<213> Homo sapiens

<400> 8644
Met Ser Ser Val Gln Ser Gln Gln Glu Gln Leu Ser Gln Ser Asp Pro 
1               5                   10                  15      


Ser Pro Ser Pro Asn Ser Cys Ser Ser Phe Glu Leu Ile Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Leu Tyr Glu Pro Val Ser Pro His Trp Phe Tyr Cys Lys 
        35                  40                  45              


Ile Ile Asp Ser Lys Glu Thr Trp Ile Pro Phe Asn Ser Glu Asp Ser 
    50                  55                  60                  


Gln Gln Leu Glu Glu Ala Tyr Ser Ser Gly Lys Gly Cys Asn Gly Arg 
65                  70                  75                  80  


Val Val Pro Thr Asp Gly Gly Arg Tyr Asp Val His Leu Gly Glu Arg 
                85                  90                  95      


Met Arg Tyr Ala Val Tyr Trp Asp Glu Leu Ala Ser Glu Val Arg Arg 
            100                 105                 110         


Cys Thr Trp Phe Tyr Lys Gly Asp Lys Asp Asn Lys Tyr Val Pro Tyr 
        115                 120                 125             


Ser Glu Ser Phe Ser Gln Val Leu Glu 
    130                 135         


<210> 8645
<211> 39
<212> PRT
<213> Homo sapiens

<400> 8645
Met Phe Trp Lys Phe Asp Leu His Ser Ser Ser His Ile Asp Thr Leu 
1               5                   10                  15      


Leu Glu Arg Glu Asp Val Thr Leu Lys Glu Leu Met Asp Glu Glu Asp 
            20                  25                  30          


Val Leu Gln Glu Cys Lys Ala 
        35                  


<210> 8646
<211> 718
<212> PRT
<213> Homo sapiens

<400> 8646
Met Leu Met Thr Leu Glu Met Thr Glu Leu Thr Asp Pro His His Thr 
1               5                   10                  15      


Met Gly Asp Tyr Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
            20                  25                  30          


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
        35                  40                  45              


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
    50                  55                  60                  


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
65                  70                  75                  80  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
                85                  90                  95      


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
            100                 105                 110         


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
        115                 120                 125             


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
    130                 135                 140                 


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
145                 150                 155                 160 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
                165                 170                 175     


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
            180                 185                 190         


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
        195                 200                 205             


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
    210                 215                 220                 


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
225                 230                 235                 240 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
                245                 250                 255     


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
            260                 265                 270         


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
        275                 280                 285             


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
    290                 295                 300                 


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
305                 310                 315                 320 


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
                325                 330                 335     


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
            340                 345                 350         


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
        355                 360                 365             


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
    370                 375                 380                 


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
385                 390                 395                 400 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
                405                 410                 415     


Phe His Arg Pro Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
            420                 425                 430         


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
        435                 440                 445             


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
    450                 455                 460                 


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
465                 470                 475                 480 


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
                485                 490                 495     


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
            500                 505                 510         


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
        515                 520                 525             


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
    530                 535                 540                 


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
545                 550                 555                 560 


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
                565                 570                 575     


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
            580                 585                 590         


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
        595                 600                 605             


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
    610                 615                 620                 


Val Arg Asp Phe Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
625                 630                 635                 640 


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
                645                 650                 655     


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
            660                 665                 670         


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
        675                 680                 685             


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
    690                 695                 700                 


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
705                 710                 715             


<210> 8647
<211> 715
<212> PRT
<213> Homo sapiens

<400> 8647
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val Gln 
65                  70                  75                  80  


Leu Ser Ser Lys Glu Lys Ile Trp Thr Gln Glu Met Leu Leu Gln Val 
                85                  90                  95      


Asn Asp Gln Ser Leu Arg Leu Leu Asp Ile Glu Ser Gln Glu Glu Leu 
            100                 105                 110         


Glu Asp Phe Pro Leu Pro Thr Val Gln Arg Ser Gln Thr Val Leu Asn 
        115                 120                 125             


Gln Leu Arg Tyr Pro Ser Val Leu Leu Leu Val Cys Gln Asp Ser Glu 
    130                 135                 140                 


Gln Ser Lys Pro Asp Val His Phe Phe His Cys Asp Glu Val Glu Ala 
145                 150                 155                 160 


Glu Leu Val His Glu Asp Ile Glu Ser Ala Leu Ala Asp Cys Arg Leu 
                165                 170                 175     


Gly Lys Lys Met Arg Pro Gln Thr Leu Lys Gly His Gln Glu Lys Ile 
            180                 185                 190         


Arg Gln Arg Gln Ser Ile Leu Pro Pro Pro Gln Gly Pro Ala Pro Ile 
        195                 200                 205             


Pro Phe Gln His Arg Gly Gly Asp Ser Pro Glu Ala Lys Asn Arg Val 
    210                 215                 220                 


Gly Pro Gln Val Pro Leu Ser Glu Pro Gly Phe Arg Arg Arg Glu Ser 
225                 230                 235                 240 


Gln Glu Glu Pro Arg Ala Val Leu Ala Gln Lys Ile Glu Lys Glu Thr 
                245                 250                 255     


Gln Ile Leu Asn Cys Ala Leu Asp Asp Ile Glu Trp Phe Val Ala Arg 
            260                 265                 270         


Leu Gln Lys Ala Ala Glu Ala Phe Lys Gln Leu Asn Gln Arg Lys Lys 
        275                 280                 285             


Gly Lys Lys Lys Gly Lys Lys Ala Pro Ala Glu Gly Val Leu Thr Leu 
    290                 295                 300                 


Arg Ala Arg Pro Pro Ser Glu Gly Glu Phe Ile Asp Cys Phe Gln Lys 
305                 310                 315                 320 


Ile Lys Leu Ala Ile Asn Leu Leu Ala Lys Leu Gln Lys His Ile Gln 
                325                 330                 335     


Asn Pro Ser Ala Ala Glu Leu Val His Phe Leu Phe Gly Pro Leu Asp 
            340                 345                 350         


Leu Ile Val Asn Thr Cys Ser Gly Pro Asp Ile Ala Arg Ser Val Ser 
        355                 360                 365             


Cys Pro Leu Leu Ser Arg Asp Ala Val Asp Phe Leu Arg Gly His Leu 
    370                 375                 380                 


Val Pro Lys Glu Met Ser Leu Trp Glu Ser Leu Gly Glu Ser Trp Met 
385                 390                 395                 400 


Arg Pro Arg Ser Glu Trp Pro Arg Glu Pro Gln Val Pro Leu Tyr Val 
                405                 410                 415     


Pro Lys Phe His Ser Gly Trp Glu Pro Pro Val Asp Val Leu Gln Glu 
            420                 425                 430         


Ala Pro Trp Glu Val Glu Gly Leu Ala Ser Ala Pro Ile Glu Glu Val 
        435                 440                 445             


Ser Pro Val Ser Arg Gln Ser Ile Arg Asn Ser Gln Lys His Ser Pro 
    450                 455                 460                 


Thr Ser Glu Pro Thr Pro Pro Gly Asp Ala Leu Pro Pro Val Ser Ser 
465                 470                 475                 480 


Pro His Thr His Arg Gly Tyr Gln Pro Thr Pro Ala Met Ala Lys Tyr 
                485                 490                 495     


Val Lys Ile Leu Tyr Asp Phe Thr Ala Arg Asn Ala Asn Glu Leu Ser 
            500                 505                 510         


Val Leu Lys Asp Glu Val Leu Glu Val Leu Glu Asp Gly Arg Gln Trp 
        515                 520                 525             


Trp Lys Leu Arg Ser Arg Ser Gly Gln Ala Gly Tyr Val Pro Cys Asn 
    530                 535                 540                 


Ile Leu Gly Glu Ala Arg Pro Glu Asp Ala Gly Ala Pro Phe Glu Gln 
545                 550                 555                 560 


Ala Gly Gln Lys Tyr Trp Gly Pro Ala Ser Pro Thr His Lys Leu Pro 
                565                 570                 575     


Pro Ser Phe Pro Gly Asn Lys Asp Glu Leu Met Gln His Met Asp Glu 
            580                 585                 590         


Val Asn Asp Glu Leu Ile Arg Lys Ile Ser Asn Ile Arg Ala Gln Pro 
        595                 600                 605             


Gln Arg His Phe Arg Val Glu Arg Ser Gln Pro Val Ser Gln Pro Leu 
    610                 615                 620                 


Thr Tyr Glu Ser Gly Pro Asp Glu Val Arg Ala Trp Leu Glu Ala Lys 
625                 630                 635                 640 


Ala Phe Ser Pro Arg Ile Val Glu Asn Leu Gly Ile Leu Thr Gly Pro 
                645                 650                 655     


Gln Leu Phe Ser Leu Asn Lys Glu Glu Leu Lys Lys Val Cys Gly Glu 
            660                 665                 670         


Glu Gly Val Arg Val Tyr Ser Gln Leu Thr Met Gln Lys Ala Phe Leu 
        675                 680                 685             


Glu Lys Gln Gln Ser Gly Ser Glu Leu Glu Glu Leu Met Asn Lys Phe 
    690                 695                 700                 


His Ser Met Asn Gln Arg Arg Gly Glu Asp Ser 
705                 710                 715 


<210> 8648
<211> 119
<212> PRT
<213> Homo sapiens

<400> 8648
Met Glu Thr Asp Leu Asn Ser Gln Asp Arg Lys Asp Leu Asp Lys Phe 
1               5                   10                  15      


Ile Lys Phe Phe Ala Leu Lys Thr Val Gln Val Ile Val Gln Ala Arg 
            20                  25                  30          


Leu Gly Glu Lys Ile Cys Thr Arg Ser Ser Ser Ser Pro Thr Gly Ser 
        35                  40                  45              


Asp Trp Phe Asn Leu Ala Ile Lys Asp Ile Pro Glu Val Thr His Glu 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Gly Gln Leu Pro Ala Val Gly Arg Ser Met 
65                  70                  75                  80  


Cys Val Glu Ile Ser Leu Lys Thr Ser Glu Gly Asp Ser Met Glu Leu 
                85                  90                  95      


Glu Ile Trp Cys Leu Glu Met Asn Glu Lys Cys Asp Lys Glu Ile Lys 
            100                 105                 110         


Val Ser Tyr Thr Val Tyr Asn 
        115                 


<210> 8649
<211> 139
<212> PRT
<213> Homo sapiens

<400> 8649
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr 
    130                 135                 


<210> 8650
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8650
Met His Asp Lys Gly Ile Thr Thr Ala Ala Val Cys Val Tyr Pro Ala 
1               5                   10                  15      


Arg Val Cys Asp Ala Val Lys Ala Leu Lys Ala Ala Gly Cys Asn Ile 
            20                  25                  30          


Pro Val Ala Ser Val Ala Ala Gly Phe Pro Ala Gly Gln Thr His Leu 
        35                  40                  45              


Lys Thr Arg Leu Glu Glu Ile Arg Leu Ala Val Glu Asp Gly Ala Thr 
    50                  55                  60                  


Glu Ile Asp Val Val Ile Asn Arg Ser Leu Val Leu Thr Gly Gln Trp 
65                  70                  75                  80  


Glu Ala Leu Tyr Asp Glu Ile Arg Gln Phe Arg Lys Ala Cys Gly Glu 
                85                  90                  95      


Ala His Leu Lys Thr Ile Leu Ala Thr Gly Glu Leu Gly Thr Leu Thr 
            100                 105                 110         


Asn Val Tyr Lys Ala Ser Met Ile Ala Met Met Ala Gly Ser Asp Phe 
        115                 120                 125             


Ile Lys Thr Ser Thr Gly Lys Glu Thr Val Asn Ala Thr Phe Pro Val 
    130                 135                 140                 


Ala Ile Val Met Leu Arg Ala Ile Arg Asp Phe Phe Trp Lys Thr Gly 
145                 150                 155                 160 


Asn Lys Val 
            


<210> 8651
<211> 151
<212> PRT
<213> Homo sapiens

<400> 8651
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr Ser Ser Pro Val Ala 
    130                 135                 140                 


Ser Gln Pro Ile Phe Ile Thr 
145                 150     


<210> 8652
<211> 83
<212> PRT
<213> Homo sapiens

<400> 8652
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val Gln 
65                  70                  75                  80  


Leu Ser Ser 
            


<210> 8653
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8653
Met Ala Gly Arg Pro Leu Arg Ile Gly Asp Gln Leu Val Leu Glu Glu 
1               5                   10                  15      


Asp Tyr Asp Glu Thr Tyr Ile Pro Ser Glu Gln Glu Ile Leu Glu Phe 
            20                  25                  30          


Ala Arg Glu Ile Gly Ile Asp Pro Ile Lys Glu Pro Glu Leu Met Trp 
        35                  40                  45              


Leu Ala Arg Glu Gly Ile Val Ala Pro Leu Pro Gly Glu Trp Lys Pro 
    50                  55                  60                  


Cys Gln Asp Ile Thr Gly Asp Ile Tyr Tyr Phe Asn Phe Ala Asn Gly 
65                  70                  75                  80  


Gln Ser Met Trp Asp His Pro Cys Asp Glu His Tyr Arg Ser Leu Val 
                85                  90                  95      


Ile Gln Glu Arg Ala Lys Leu Ser Thr Ser Gly Ala Ile Lys Lys Lys 
            100                 105                 110         


Lys Lys Lys Lys Glu Lys Lys Asp Lys 
        115                 120     


<210> 8654
<211> 998
<212> PRT
<213> Homo sapiens

<400> 8654
Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe 
        115                 120                 125             


Gly Val Thr Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser 
    130                 135                 140                 


Asn Phe Leu Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu 
145                 150                 155                 160 


Val Ala Cys Gln Ile Val Leu Pro Asp Pro Gly Ile Ala Gly Phe Thr 
                165                 170                 175     


Val Ile Asp Tyr Phe His Gln Leu Leu Gln Thr Phe Asn Phe Arg Lys 
            180                 185                 190         


Leu Gln Cys Asp Ser Gln Ala Pro Asn Asn His Leu Leu Ala Leu Asp 
        195                 200                 205             


His Ser Asn Ser Asp Leu Ser Ser Ile Tyr Thr Ser Asp Ser Thr Ser 
    210                 215                 220                 


Asp Phe Phe Lys Ser Cys Ser Lys Asp Thr Phe Ser Lys Phe Trp Gln 
225                 230                 235                 240 


Pro Ser Leu Glu Phe Thr Cys Ile Val Ser Gln Leu Thr Asp Asn Asp 
                245                 250                 255     


Asp Phe Ser Ala Ser Glu Gln Ser Lys Ala Phe Gly Thr Leu Gln Gln 
            260                 265                 270         


Asn Arg Lys Ser Ile Ser Ile Ala Glu Ala Thr Gly Ser Ser Ser Cys 
        275                 280                 285             


His Asp Pro Ile Gln Asp Ser Trp Ser Leu Val Ser Tyr Met Asp Lys 
    290                 295                 300                 


Lys Ser Thr Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu Gln Ala Lys 
305                 310                 315                 320 


Glu Leu Ser Ala Val His Ser Ser His His Glu Ile Gly Val Asn Asp 
                325                 330                 335     


Ser Asn Leu Phe Ser Leu Glu Met Arg Glu Pro Leu Glu Ser Ser Asn 
            340                 345                 350         


Thr Lys Ser Phe His Ser Ala Val Glu Ile Lys Asn Arg Ser Gln His 
        355                 360                 365             


Glu Leu Pro Cys Phe Gln His His Gly Ile Asp Thr Pro Thr Ser Leu 
    370                 375                 380                 


Gln Lys Arg Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg Leu Glu Glu 
385                 390                 395                 400 


Thr Ala Ser Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp Asp Asp Leu 
                405                 410                 415     


Pro Phe Ser Glu Ser Leu Asn Lys Phe Leu Ala Val Leu Glu Ser Glu 
            420                 425                 430         


Ile Ala Val Thr Gln Ala Asp Val Ser Ser Arg Lys His His Val Asp 
        435                 440                 445             


Asn Asp Ile Asp Lys Phe His Ala Asp His Ser Arg Leu Ser Val Thr 
    450                 455                 460                 


Pro Gln Arg Thr Thr Gly Ala Leu His Thr Pro Pro Ile Ala Leu Arg 
465                 470                 475                 480 


Ser Ser Gln Val Ile Val Lys Ala Asn Cys Ser Lys Asp Asp Phe Leu 
                485                 490                 495     


Phe Asn Cys Lys Gly Asn Leu Ser Pro Ser Val Glu Lys Glu Ser Gln 
            500                 505                 510         


Pro Asp Asn Lys Val Glu Ala Val Ser Val Asn His Asn Gly Arg Asp 
        515                 520                 525             


Met Ser Glu Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala Leu Ser Ser 
    530                 535                 540                 


Ser Ser Lys Asp Leu Glu Thr Ile Val Thr Leu Lys Lys Thr Ile Arg 
545                 550                 555                 560 


Ile Ser Pro His Arg Glu Ser Asp His Ser Ser Leu Asn Asn Lys Tyr 
                565                 570                 575     


Leu Asn Gly Cys Gly Glu Ile Ser Val Ser Glu Met Asn Glu Lys Leu 
            580                 585                 590         


Thr Thr Leu Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp Leu Cys Lys 
        595                 600                 605             


Leu Glu Asn Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln Asp Asp Ser 
    610                 615                 620                 


Phe Thr Ile Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr Leu Cys Asn 
625                 630                 635                 640 


Ser Pro Asn Arg Ser Thr Asn Thr Leu Lys Glu Met Pro Trp Gly His 
                645                 650                 655     


Ile Asn Asn Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr Glu Gly Ser 
            660                 665                 670         


Tyr Asp Ala Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys Glu Met Asp 
        675                 680                 685             


Ile Ala Thr Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu Leu Lys Trp 
    690                 695                 700                 


Gly Thr Ser Leu Ala Glu Ser His Pro Ser Glu Ser Asp Phe Ser Leu 
705                 710                 715                 720 


Arg Ser Leu Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys Leu Ser Leu 
                725                 730                 735     


Gln Ser Leu Ser Asp Ser Arg His Ser Arg Thr Cys Ser Pro Thr Pro 
            740                 745                 750         


His Phe Gln Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser Gln Asp Phe 
        755                 760                 765             


Val Pro Cys Ser Gln Ser Thr Pro Ile Ser Gly Phe His Gln Thr Arg 
    770                 775                 780                 


Ile His Gly Ile Asn Arg Ala Phe Lys Lys Pro Val Phe Tyr Ser Asp 
785                 790                 795                 800 


Leu Asp Gly Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu Asn Asp Lys 
                805                 810                 815     


Gln Gln Ala Ser Pro Ser Cys Pro Lys Asn Ile Lys Thr Pro Ser Gln 
            820                 825                 830         


Lys Ile Arg Ser Pro Ile Val Ser Gly Val Ser Gln Pro Asp Val Phe 
        835                 840                 845             


Asn His Tyr Pro Phe Ala Glu Cys His Glu Thr Asp Ser Asp Glu Trp 
    850                 855                 860                 


Val Pro Pro Thr Thr Gln Lys Ile Phe Pro Ser Asp Met Leu Gly Phe 
865                 870                 875                 880 


Gln Gly Ile Gly Leu Gly Lys Cys Leu Ala Ala Tyr His Phe Pro Asp 
                885                 890                 895     


Gln Gln Glu Leu Pro Arg Lys Lys Leu Lys His Ile Arg Gln Gly Thr 
            900                 905                 910         


Asn Lys Gly Leu Ile Lys Lys Lys Leu Lys Asn Met Leu Ala Ala Val 
        915                 920                 925             


Val Thr Lys Lys Lys Thr His Lys Tyr Asn Cys Lys Ser Ser Gly Trp 
    930                 935                 940                 


Ile Ser Lys Cys Pro Asp Ile Gln Val Leu Ala Ala Pro Gln Leu His 
945                 950                 955                 960 


Pro Ile Leu Gly Pro Asp Ser Cys Ser Glu Val Lys Cys Cys Leu Pro 
                965                 970                 975     


Phe Ser Glu Lys Gly Pro Pro Ser Val Cys Glu Thr Arg Ser Ala Trp 
            980                 985                 990         


Ser Pro Glu Leu Phe Ser 
        995             


<210> 8655
<211> 167
<212> PRT
<213> Homo sapiens

<400> 8655
Met Gly Thr Thr Ala Pro Gly Pro Ile His Leu Leu Glu Leu Cys Asp 
1               5                   10                  15      


Gln Lys Leu Met Glu Phe Leu Cys Asn Met Asp Asn Lys Asp Leu Val 
            20                  25                  30          


Trp Leu Glu Glu Ile Gln Glu Glu Ala Glu Arg Met Phe Thr Arg Glu 
        35                  40                  45              


Phe Ser Lys Glu Pro Glu Leu Met Pro Lys Thr Pro Ser Gln Lys Asn 
    50                  55                  60                  


Arg Arg Lys Lys Arg Arg Ile Ser Tyr Val Gln Asp Glu Asn Arg Asp 
65                  70                  75                  80  


Pro Ile Arg Arg Arg Leu Ser Arg Arg Lys Ser Arg Ser Ser Gln Leu 
                85                  90                  95      


Ser Ser Arg Arg Leu Arg Ser Lys Asp Ser Val Glu Lys Leu Ala Thr 
            100                 105                 110         


Val Val Gly Glu Asn Gly Ser Val Leu Arg Arg Val Thr Arg Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Thr Met Ala Leu Ala Ala Pro Ser Ser Pro 
    130                 135                 140                 


Thr Pro Glu Ser Pro Thr Met Leu Thr Lys Lys Pro Glu Asp Asn His 
145                 150                 155                 160 


Thr Gln Cys Gln Leu Val Pro 
                165         


<210> 8656
<211> 204
<212> PRT
<213> Homo sapiens

<400> 8656
Met Glu Ala Gln Ala Gln Gly Leu Leu Glu Thr Glu Pro Leu Gln Gly 
1               5                   10                  15      


Thr Asp Glu Asp Ala Val Ala Ser Ala Asp Phe Ser Ser Met Leu Ser 
            20                  25                  30          


Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln Leu Glu Asp 
        35                  40                  45              


Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu Arg His Leu 
    50                  55                  60                  


Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn Glu Leu Lys 
65                  70                  75                  80  


Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr Thr Ala Tyr 
                85                  90                  95      


Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys Ala Thr Ala 
            100                 105                 110         


Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe Gly Asp Met 
        115                 120                 125             


Ser Tyr Ser Ile Arg His Ser Ile Ser Met Pro Ala Met Arg Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys Ser Phe Glu Glu Arg Val Glu Thr Thr Val Thr Ser 
145                 150                 155                 160 


Leu Lys Thr Lys Val Gly Gly Thr Asn Pro Asn Gly Gly Ser Phe Glu 
                165                 170                 175     


Glu Val Leu Ser Ser Thr Ala His Ala Ser Ala Gln Ser Leu Ala Gly 
            180                 185                 190         


Gly Ser Arg Arg Thr Lys Glu Glu Glu Leu Gln Cys 
        195                 200                 


<210> 8657
<211> 340
<212> PRT
<213> Homo sapiens

<400> 8657
Met Ala Ala Ala Arg Asp Pro Pro Glu Val Ser Leu Arg Glu Ala Thr 
1               5                   10                  15      


Gln Arg Lys Leu Arg Arg Phe Ser Glu Leu Arg Gly Lys Leu Val Ala 
            20                  25                  30          


Arg Gly Glu Phe Trp Asp Ile Val Ala Ile Thr Ala Ala Asp Glu Lys 
        35                  40                  45              


Gln Glu Leu Ala Tyr Asn Gln Gln Leu Ser Glu Lys Leu Lys Arg Lys 
    50                  55                  60                  


Glu Leu Pro Leu Gly Val Gln Tyr His Val Phe Val Asp Pro Ala Gly 
65                  70                  75                  80  


Ala Lys Ile Gly Asn Gly Gly Ser Thr Leu Cys Ala Leu Gln Cys Leu 
                85                  90                  95      


Glu Lys Leu Tyr Gly Asp Lys Trp Asn Ser Phe Thr Ile Leu Leu Ile 
            100                 105                 110         


His Ser Gly Gly Tyr Ser Gln Arg Leu Pro Asn Ala Ser Ala Leu Gly 
        115                 120                 125             


Lys Ile Phe Thr Ala Leu Pro Leu Asp Ile Pro Glu Cys Ser Gly Lys 
    130                 135                 140                 


Thr Ser Cys Ile Ile Gln Ser Ile Leu Asp Ser Arg Cys Ser Val Ala 
145                 150                 155                 160 


Pro Gly Ser Val Val Glu Tyr Ser Arg Leu Gly Pro Asp Val Ser Val 
                165                 170                 175     


Gly Glu Asn Cys Ile Ile Ser Gly Ser Tyr Ile Leu Thr Lys Ala Ala 
            180                 185                 190         


Leu Pro Ala His Ser Phe Val Cys Ser Leu Ser Leu Lys Met Asn Arg 
        195                 200                 205             


Cys Leu Lys Tyr Ala Thr Met Ala Phe Gly Val Gln Asp Asn Leu Lys 
    210                 215                 220                 


Lys Ser Val Lys Thr Leu Ser Asp Ile Lys Leu Leu Gln Phe Phe Gly 
225                 230                 235                 240 


Val Cys Phe Leu Ser Cys Leu Asp Val Trp Asn Leu Lys Val Thr Glu 
                245                 250                 255     


Glu Leu Phe Ser Gly Asn Lys Thr Cys Leu Ser Leu Trp Thr Ala Arg 
            260                 265                 270         


Ile Phe Pro Val Cys Ser Ser Leu Ser Asp Ser Val Ile Thr Ser Leu 
        275                 280                 285             


Lys Met Leu Asn Ala Val Lys Asn Lys Ser Ala Phe Ser Leu Asn Ser 
    290                 295                 300                 


Tyr Lys Leu Leu Ser Ile Glu Glu Met Leu Ile Tyr Lys Asp Val Glu 
305                 310                 315                 320 


Asp Met Ile Thr Tyr Arg Glu Gln Ile Phe Leu Glu Ile Ser Leu Lys 
                325                 330                 335     


Ser Ser Leu Met 
            340 


<210> 8658
<211> 290
<212> PRT
<213> Homo sapiens

<400> 8658
Met Ala Glu Leu Thr Ala Leu Glu Ser Leu Ile Glu Met Gly Phe Pro 
1               5                   10                  15      


Arg Gly Arg Ala Glu Lys Ala Leu Ala Leu Thr Gly Asn Gln Gly Ile 
            20                  25                  30          


Glu Ala Ala Met Asp Trp Leu Met Glu His Glu Asp Asp Pro Asp Val 
        35                  40                  45              


Asp Glu Pro Leu Glu Thr Pro Leu Gly His Ile Leu Gly Arg Glu Pro 
    50                  55                  60                  


Thr Ser Ser Glu Gln Gly Gly Leu Glu Gly Ser Gly Ser Ala Ala Gly 
65                  70                  75                  80  


Glu Gly Lys Pro Ala Leu Ser Glu Glu Glu Arg Gln Glu Gln Thr Lys 
                85                  90                  95      


Arg Met Leu Glu Leu Val Ala Gln Lys Gln Arg Glu Arg Glu Glu Arg 
            100                 105                 110         


Glu Glu Arg Glu Ala Leu Glu Arg Glu Arg Gln Arg Arg Arg Gln Gly 
        115                 120                 125             


Gln Glu Leu Ser Ala Ala Arg Gln Arg Leu Gln Glu Asp Glu Met Arg 
    130                 135                 140                 


Arg Ala Ala Glu Glu Arg Arg Arg Glu Lys Ala Glu Glu Leu Ala Ala 
145                 150                 155                 160 


Arg Gln Arg Val Arg Glu Lys Ile Glu Arg Asp Lys Ala Glu Arg Ala 
                165                 170                 175     


Lys Lys Tyr Gly Gly Ser Val Gly Ser Gln Pro Pro Pro Val Ala Pro 
            180                 185                 190         


Glu Pro Gly Pro Val Pro Ser Ser Pro Ser Gln Glu Pro Pro Thr Lys 
        195                 200                 205             


Arg Glu Tyr Asp Gln Cys Arg Ile Gln Val Arg Leu Pro Asp Gly Thr 
    210                 215                 220                 


Ser Leu Thr Gln Thr Phe Arg Ala Arg Glu Gln Leu Ala Ala Val Arg 
225                 230                 235                 240 


Leu Tyr Val Glu Leu His Arg Gly Glu Glu Leu Gly Gly Gly Gln Asp 
                245                 250                 255     


Pro Val Gln Leu Leu Ser Gly Phe Pro Arg Arg Ala Phe Ser Glu Ala 
            260                 265                 270         


Asp Met Glu Arg Pro Leu Gln Glu Leu Gly Leu Val Pro Ser Ala Val 
        275                 280                 285             


Leu Ile 
    290 


<210> 8659
<211> 102
<212> PRT
<213> Homo sapiens

<400> 8659
Met Leu Ser Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln 
1               5                   10                  15      


Leu Glu Asp Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu 
            20                  25                  30          


Arg His Leu Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn 
        35                  40                  45              


Glu Leu Lys Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr 
    50                  55                  60                  


Thr Ala Tyr Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys 
65                  70                  75                  80  


Ala Thr Ala Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe 
                85                  90                  95      


Gly Asp Met Arg Arg Lys 
            100         


<210> 8660
<211> 92
<212> PRT
<213> Homo sapiens

<400> 8660
Met Leu Ser Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln 
1               5                   10                  15      


Leu Glu Asp Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu 
            20                  25                  30          


Arg His Leu Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn 
        35                  40                  45              


Glu Leu Lys Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr 
    50                  55                  60                  


Thr Ala Tyr Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys 
65                  70                  75                  80  


Ala Thr Ala Ala Phe Ser Asn Val Gly Thr Ala Ile 
                85                  90          


<210> 8661
<211> 1244
<212> PRT
<213> Homo sapiens

<400> 8661
Met Leu Ile Lys Glu Tyr His Ile Leu Leu Pro Met Ser Leu Asp Glu 
1               5                   10                  15      


Tyr Gln Val Ala Gln Leu Tyr Met Ile Gln Lys Lys Ser Arg Glu Glu 
            20                  25                  30          


Ser Ser Gly Glu Gly Ser Gly Val Glu Ile Leu Ala Asn Arg Pro Tyr 
        35                  40                  45              


Thr Asp Gly Pro Gly Gly Ser Gly Gln Tyr Thr His Lys Val Tyr His 
    50                  55                  60                  


Val Gly Ser His Ile Pro Gly Trp Phe Arg Ala Leu Leu Pro Lys Ala 
65                  70                  75                  80  


Ala Leu Gln Val Glu Glu Glu Ser Trp Asn Ala Tyr Pro Tyr Thr Arg 
                85                  90                  95      


Thr Arg Tyr Thr Cys Pro Phe Val Glu Lys Phe Ser Ile Glu Ile Glu 
            100                 105                 110         


Thr Tyr Tyr Leu Pro Asp Gly Gly Gln Gln Pro Asn Val Phe Asn Leu 
        115                 120                 125             


Ser Gly Ala Glu Arg Arg Gln Arg Ile Leu Asp Thr Ile Asp Ile Val 
    130                 135                 140                 


Arg Asp Ala Val Ala Pro Gly Glu Tyr Lys Ala Glu Glu Asp Pro Arg 
145                 150                 155                 160 


Leu Tyr His Ser Val Lys Thr Gly Arg Gly Pro Leu Ser Asp Asp Trp 
                165                 170                 175     


Ala Arg Thr Ala Ala Gln Thr Gly Pro Leu Met Cys Ala Tyr Lys Leu 
            180                 185                 190         


Cys Lys Val Glu Phe Arg Tyr Trp Gly Met Gln Ala Lys Ile Glu Gln 
        195                 200                 205             


Phe Ile His Asp Val Gly Leu Arg Arg Val Met Leu Arg Ala His Arg 
    210                 215                 220                 


Gln Ala Trp Cys Trp Gln Asp Glu Trp Thr Glu Leu Ser Met Ala Asp 
225                 230                 235                 240 


Ile Arg Ala Leu Glu Glu Glu Thr Ala Arg Met Leu Ala Gln Arg Met 
                245                 250                 255     


Ala Lys Cys Asn Thr Gly Ser Glu Gly Ser Glu Ala Gln Pro Pro Gly 
            260                 265                 270         


Lys Pro Ser Thr Glu Ala Arg Ser Ala Ala Ser Asn Thr Gly Thr Pro 
        275                 280                 285             


Asp Gly Pro Glu Ala Pro Pro Gly Pro Asp Ala Ser Pro Asp Ala Ser 
    290                 295                 300                 


Phe Gly Lys Gln Trp Ser Ser Ser Ser Arg Ser Ser Tyr Ser Ser Gln 
305                 310                 315                 320 


His Gly Gly Ala Val Ser Pro Gln Ser Leu Ser Glu Trp Arg Met Gln 
                325                 330                 335     


Asn Ile Ala Arg Asp Ser Glu Asn Ser Ser Glu Glu Glu Phe Phe Asp 
            340                 345                 350         


Ala His Glu Gly Phe Ser Asp Ser Glu Glu Val Phe Pro Lys Glu Met 
        355                 360                 365             


Thr Lys Trp Asn Ser Asn Asp Phe Ile Asp Ala Phe Ala Ser Pro Val 
    370                 375                 380                 


Glu Ala Glu Gly Thr Pro Glu Pro Gly Ala Glu Ala Ala Lys Gly Ile 
385                 390                 395                 400 


Glu Asp Gly Ala Gln Ala Pro Arg Asp Ser Glu Gly Leu Asp Gly Ala 
                405                 410                 415     


Gly Glu Leu Gly Ala Glu Ala Cys Ala Val His Ala Leu Phe Leu Ile 
            420                 425                 430         


Leu His Ser Gly Asn Ile Leu Asp Ser Gly Pro Gly Asp Ala Asn Ser 
        435                 440                 445             


Lys Gln Ala Asp Val Gln Thr Leu Ser Ser Ala Phe Glu Ala Val Thr 
    450                 455                 460                 


Arg Ile His Phe Pro Glu Ala Leu Gly His Val Ala Leu Arg Leu Val 
465                 470                 475                 480 


Pro Cys Pro Pro Ile Cys Ala Ala Ala Tyr Ala Leu Val Ser Asn Leu 
                485                 490                 495     


Ser Pro Tyr Ser His Asp Gly Asp Ser Leu Ser Arg Ser Gln Asp His 
            500                 505                 510         


Ile Pro Leu Ala Ala Leu Pro Leu Leu Ala Thr Ser Ser Ser Arg Tyr 
        515                 520                 525             


Gln Gly Ala Val Ala Thr Val Ile Ala Arg Thr Asn Gln Ala Tyr Ser 
    530                 535                 540                 


Ala Phe Leu Arg Ser Pro Glu Gly Ala Gly Phe Cys Gly Gln Val Ala 
545                 550                 555                 560 


Leu Ile Gly Asp Gly Val Gly Gly Ile Leu Gly Phe Asp Ala Leu Cys 
                565                 570                 575     


His Ser Ala Asn Ala Gly Thr Gly Ser Arg Gly Ser Ser Arg Arg Gly 
            580                 585                 590         


Ser Met Asn Asn Glu Leu Leu Ser Pro Glu Phe Gly Pro Val Arg Asp 
        595                 600                 605             


Pro Leu Ala Asp Gly Val Glu Gly Leu Gly Arg Gly Ser Pro Glu Pro 
    610                 615                 620                 


Ser Ala Leu Pro Pro Gln Arg Ile Pro Ser Asp Met Ala Ser Pro Glu 
625                 630                 635                 640 


Pro Glu Gly Ser Gln Asn Ser Leu Gln Ala Ala Pro Ala Thr Thr Ser 
                645                 650                 655     


Ser Trp Glu Pro Arg Arg Ala Ser Thr Ala Phe Cys Pro Pro Ala Ala 
            660                 665                 670         


Ser Ser Glu Ala Pro Asp Gly Pro Ser Ser Thr Ala Arg Leu Asp Phe 
        675                 680                 685             


Lys Val Ser Gly Phe Phe Leu Phe Gly Ser Pro Leu Gly Leu Val Leu 
    690                 695                 700                 


Ala Leu Arg Lys Thr Val Met Pro Ala Leu Glu Ala Ala Gln Met Arg 
705                 710                 715                 720 


Pro Ala Cys Glu Gln Ile Tyr Asn Leu Phe His Ala Ala Asp Pro Cys 
                725                 730                 735     


Ala Ser Arg Leu Glu Pro Leu Leu Ala Pro Lys Phe Gln Ala Ile Ala 
            740                 745                 750         


Pro Leu Thr Val Pro Arg Tyr Gln Lys Phe Pro Leu Gly Asp Gly Ser 
        755                 760                 765             


Ser Leu Leu Leu Ala Asp Thr Leu Gln Thr His Ser Ser Leu Phe Leu 
    770                 775                 780                 


Glu Glu Leu Glu Met Leu Val Pro Ser Thr Pro Thr Ser Thr Ser Gly 
785                 790                 795                 800 


Ala Phe Trp Lys Gly Ser Glu Leu Ala Thr Asp Pro Pro Ala Gln Pro 
                805                 810                 815     


Ala Ala Pro Ser Thr Thr Ser Glu Val Val Lys Ile Leu Glu Arg Trp 
            820                 825                 830         


Trp Gly Thr Lys Arg Ile Asp Tyr Ser Leu Tyr Cys Pro Glu Ala Leu 
        835                 840                 845             


Thr Ala Phe Pro Thr Val Thr Leu Pro His Leu Phe His Ala Ser Tyr 
    850                 855                 860                 


Trp Glu Ser Ala Asp Val Val Ala Phe Ile Leu Arg Gln Val Ile Glu 
865                 870                 875                 880 


Lys Glu Arg Pro Gln Leu Ala Glu Cys Glu Glu Pro Ser Ile Tyr Ser 
                885                 890                 895     


Pro Ala Phe Pro Arg Glu Lys Trp Gln Arg Lys Arg Thr Gln Val Lys 
            900                 905                 910         


Ile Arg Asn Val Thr Ser Asn His Arg Ala Ser Asp Thr Val Val Cys 
        915                 920                 925             


Glu Gly Arg Pro Gln Val Leu Ser Gly Arg Phe Met Tyr Gly Pro Leu 
    930                 935                 940                 


Asp Val Val Thr Leu Thr Gly Glu Lys Val Asp Val Tyr Ile Met Thr 
945                 950                 955                 960 


Gln Pro Leu Ser Gly Lys Trp Ile His Phe Gly Thr Glu Val Thr Asn 
                965                 970                 975     


Ser Ser Gly Arg Leu Thr Phe Pro Val Pro Pro Glu Arg Ala Leu Gly 
            980                 985                 990         


Ile Gly Val Tyr Pro Val Arg Met  Val Val Arg Gly Asp  His Thr Tyr 
        995                 1000                 1005             


Ala Glu  Cys Cys Leu Thr Val  Val Ala Arg Gly Thr  Glu Ala Val 
    1010                 1015                 1020             


Val Phe  Ser Ile Asp Gly Ser  Phe Thr Ala Ser Val  Ser Ile Met 
    1025                 1030                 1035             


Gly Ser  Asp Pro Lys Val Arg  Ala Gly Ala Val Asp  Val Val Arg 
    1040                 1045                 1050             


His Trp  Gln Asp Ser Gly Tyr  Leu Ile Val Tyr Val  Thr Gly Arg 
    1055                 1060                 1065             


Pro Asp  Met Gln Lys His Arg  Val Val Ala Trp Leu  Ser Gln His 
    1070                 1075                 1080             


Asn Phe  Pro His Gly Val Val  Ser Phe Cys Asp Gly  Leu Thr His 
    1085                 1090                 1095             


Asp Pro  Leu Arg Gln Lys Ala  Met Phe Leu Gln Ser  Leu Val Gln 
    1100                 1105                 1110             


Glu Val  Glu Leu Asn Ile Val  Ala Gly Tyr Gly Ser  Pro Lys Asp 
    1115                 1120                 1125             


Val Ala  Val Tyr Ala Ala Leu  Gly Leu Ser Pro Ser  Gln Thr Tyr 
    1130                 1135                 1140             


Ile Val  Gly Arg Ala Val Arg  Lys Leu Gln Ala Gln  Cys Gln Phe 
    1145                 1150                 1155             


Leu Ser  Asp Gly Tyr Val Ala  His Leu Gly Gln Leu  Glu Ala Gly 
    1160                 1165                 1170             


Ser His  Ser His Ala Ser Ser  Gly Pro Pro Arg Ala  Ala Leu Gly 
    1175                 1180                 1185             


Lys Ser  Ser Tyr Gly Val Ala  Ala Pro Val Asp Phe  Leu Arg Lys 
    1190                 1195                 1200             


Gln Ser  Gln Leu Leu Arg Ser  Arg Gly Pro Ser Gln  Ala Glu Arg 
    1205                 1210                 1215             


Glu Gly  Pro Gly Thr Pro Pro  Thr Thr Leu Ala Arg  Gly Lys Ala 
    1220                 1225                 1230             


Arg Ser  Ile Ser Leu Lys Leu  Asp Ser Glu Glu 
    1235                 1240                 


<210> 8662
<211> 891
<212> PRT
<213> Homo sapiens

<400> 8662
Met Asp Gln Pro Glu Ala Pro Cys Ser Ser Thr Gly Pro Arg Leu Ala 
1               5                   10                  15      


Val Ala Arg Glu Leu Leu Leu Ala Ala Leu Glu Glu Leu Ser Gln Glu 
            20                  25                  30          


Gln Leu Lys Arg Phe Arg His Lys Leu Arg Asp Val Gly Pro Asp Gly 
        35                  40                  45              


Arg Ser Ile Pro Trp Gly Arg Leu Glu Arg Ala Asp Ala Val Asp Leu 
    50                  55                  60                  


Ala Glu Gln Leu Ala Gln Phe Tyr Gly Pro Glu Pro Ala Leu Glu Val 
65                  70                  75                  80  


Ala Arg Lys Thr Leu Lys Arg Ala Asp Ala Arg Asp Val Ala Ala Gln 
                85                  90                  95      


Leu Gln Glu Arg Arg Leu Gln Arg Leu Gly Leu Gly Ser Gly Thr Leu 
            100                 105                 110         


Leu Ser Val Ser Glu Tyr Lys Lys Lys Tyr Arg Glu His Val Leu Gln 
        115                 120                 125             


Leu His Ala Arg Val Lys Glu Arg Asn Ala Arg Ser Val Lys Ile Thr 
    130                 135                 140                 


Lys Arg Phe Thr Lys Leu Leu Ile Ala Pro Glu Ser Ala Ala Pro Glu 
145                 150                 155                 160 


Glu Ala Met Gly Pro Ala Glu Glu Pro Glu Pro Gly Arg Ala Arg Arg 
                165                 170                 175     


Ser Asp Thr His Thr Phe Asn Arg Leu Phe Arg Arg Asp Glu Glu Gly 
            180                 185                 190         


Arg Arg Pro Leu Thr Val Val Leu Gln Gly Pro Ala Gly Ile Gly Lys 
        195                 200                 205             


Thr Met Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu 
    210                 215                 220                 


Tyr Gln Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu 
225                 230                 235                 240 


Leu Glu Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln 
                245                 250                 255     


Cys Pro Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln 
            260                 265                 270         


Arg Leu Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly 
        275                 280                 285             


Gly Pro Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly 
    290                 295                 300                 


Ala Arg Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala 
305                 310                 315                 320 


Leu Leu Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly 
                325                 330                 335     


Arg Leu Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys 
            340                 345                 350         


Asp Lys Lys Lys Tyr Phe Tyr Lys Tyr Phe Arg Asp Glu Arg Arg Ala 
        355                 360                 365             


Glu Arg Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu 
    370                 375                 380                 


Cys Phe Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln 
385                 390                 395                 400 


Gln Leu Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr 
                405                 410                 415     


Ser Val Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val 
            420                 425                 430         


Ala Asp Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu 
        435                 440                 445             


Ala Arg Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu 
    450                 455                 460                 


Leu Glu Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu 
465                 470                 475                 480 


Ser Lys Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln 
                485                 490                 495     


Phe Ile Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu 
            500                 505                 510         


Leu Glu Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr 
        515                 520                 525             


Leu Leu Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr 
    530                 535                 540                 


Arg Phe Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu 
545                 550                 555                 560 


Arg His Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu 
                565                 570                 575     


Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu 
            580                 585                 590         


Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu 
        595                 600                 605             


Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys 
    610                 615                 620                 


Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg 
625                 630                 635                 640 


Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val 
                645                 650                 655     


Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu 
            660                 665                 670         


Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys 
        675                 680                 685             


Ser Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly Gly Ser Ser Gln 
    690                 695                 700                 


Gly Thr Thr Lys Gln Leu Pro Ala Ser Leu Leu His Pro Leu Phe Gln 
705                 710                 715                 720 


Ala Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu Thr Leu Ser His 
                725                 730                 735     


Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser Glu Ala Leu Arg 
            740                 745                 750         


Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His Asn Arg Leu Ser 
        755                 760                 765             


Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala Trp Pro Gln Cys 
    770                 775                 780                 


Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro Gln Arg Gly Leu 
785                 790                 795                 800 


Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala Leu Thr Thr Leu 
                805                 810                 815     


Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val Thr Tyr Leu Cys 
            820                 825                 830         


Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr Leu Ser Leu Ala 
        835                 840                 845             


Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu Gln Ala Val Lys 
    850                 855                 860                 


Arg Ala Lys Pro Asp Leu Val Ile Thr His Pro Ala Leu Asp Gly His 
865                 870                 875                 880 


Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe 
                885                 890     


<210> 8663
<211> 79
<212> PRT
<213> Homo sapiens

<400> 8663
Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val 
65                  70                  75                  


<210> 8664
<211> 180
<212> PRT
<213> Homo sapiens

<400> 8664
Met Gly Asp Lys Lys Ser Pro Thr Arg Pro Lys Arg Gln Pro Lys Pro 
1               5                   10                  15      


Ser Ser Asp Glu Gly Tyr Trp Asp Cys Ser Val Cys Thr Phe Arg Asn 
            20                  25                  30          


Ser Ala Glu Ala Phe Lys Cys Met Met Cys Asp Val Arg Lys Gly Thr 
        35                  40                  45              


Ser Thr Arg Lys Pro Arg Pro Val Ser Gln Leu Val Ala Gln Gln Val 
    50                  55                  60                  


Thr Gln Gln Phe Val Pro Pro Thr Gln Ser Lys Lys Glu Lys Lys Asp 
65                  70                  75                  80  


Lys Val Glu Lys Glu Lys Ser Glu Lys Glu Thr Thr Ser Lys Lys Asn 
                85                  90                  95      


Ser His Lys Lys Thr Arg Pro Arg Leu Lys Asn Val Asp Arg Ser Ser 
            100                 105                 110         


Ala Gln His Leu Glu Val Thr Val Gly Asp Leu Thr Val Ile Ile Thr 
        115                 120                 125             


Asp Phe Lys Glu Lys Thr Lys Ser Pro Pro Ala Ser Ser Ala Ala Ser 
    130                 135                 140                 


Ala Asp Gln His Ser Gln Ser Gly Ser Ser Ser Asp Asn Thr Glu Arg 
145                 150                 155                 160 


Gly Met Ser Arg Ser Ser Ser Pro Arg Gly Glu Ala Ser Ser Leu Asn 
                165                 170                 175     


Gly Glu Ser His 
            180 


<210> 8665
<211> 731
<212> PRT
<213> Homo sapiens

<400> 8665
Met Gly Ser Gly Glu Glu Pro Gly Gln Ser Gly Ala Ser Leu Arg Thr 
1               5                   10                  15      


Gly Pro Met Val Gln Gly Arg Gly Ile Met Thr Thr Gly Ser Gly Gln 
            20                  25                  30          


Glu Pro Gly Gln Ser Gly Thr Ser Leu Arg Thr Gly Pro Met Gly Ser 
        35                  40                  45              


Leu Gly Gln Ala Glu Gln Val Ser Ser Met Pro Met Gly Ser Leu Glu 
    50                  55                  60                  


His Glu Gly Leu Val Ser Leu Arg Pro Val Gly Leu Gln Glu Gln Glu 
65                  70                  75                  80  


Gly Pro Met Ser Leu Gly Pro Val Gly Ser Ala Gly Pro Val Glu Thr 
                85                  90                  95      


Ser Lys Gly Leu Leu Gly Gln Glu Gly Leu Val Glu Ile Ala Met Asp 
            100                 105                 110         


Ser Pro Glu Gln Glu Gly Leu Val Gly Pro Met Glu Ile Thr Met Gly 
        115                 120                 125             


Ser Leu Glu Lys Ala Gly Pro Val Ser Pro Gly Cys Val Lys Leu Ala 
    130                 135                 140                 


Gly Gln Glu Gly Leu Val Glu Met Val Leu Leu Met Glu Pro Gly Ala 
145                 150                 155                 160 


Met Arg Phe Leu Gln Leu Tyr His Glu Asp Leu Leu Ala Gly Leu Gly 
                165                 170                 175     


Asp Val Ala Leu Leu Pro Leu Glu Gly Pro Asp Met Thr Gly Phe Arg 
            180                 185                 190         


Leu Cys Gly Ala Gln Ala Ser Cys Gln Ala Ala Glu Glu Phe Leu Arg 
        195                 200                 205             


Ser Leu Leu Gly Ser Ile Ser Cys His Val Leu Cys Leu Glu His Pro 
    210                 215                 220                 


Gly Ser Ala Arg Phe Leu Leu Gly Pro Glu Gly Gln His Leu Leu Gln 
225                 230                 235                 240 


Gly Leu Glu Ala Gln Phe Gln Cys Val Phe Gly Thr Glu Arg Leu Ala 
                245                 250                 255     


Thr Ala Thr Leu Asp Thr Gly Leu Glu Glu Val Asp Pro Thr Glu Ala 
            260                 265                 270         


Leu Pro Val Leu Pro Gly Asn Ala His Thr Leu Trp Thr Pro Asp Ser 
        275                 280                 285             


Thr Gly Gly Asp Gln Glu Asp Val Ser Leu Glu Glu Val Arg Glu Leu 
    290                 295                 300                 


Leu Ala Thr Leu Glu Gly Leu Asp Leu Asp Gly Glu Asp Trp Leu Pro 
305                 310                 315                 320 


Arg Glu Leu Glu Glu Glu Gly Pro Gln Glu Gln Pro Glu Glu Glu Val 
                325                 330                 335     


Thr Pro Gly His Glu Glu Glu Glu Pro Val Ala Pro Ser Thr Val Ala 
            340                 345                 350         


Pro Arg Trp Leu Glu Glu Glu Ala Ala Leu Gln Leu Ala Leu His Arg 
        355                 360                 365             


Ser Leu Glu Pro Gln Gly Gln Val Ala Glu Gln Glu Glu Ala Ala Ala 
    370                 375                 380                 


Leu Arg Gln Ala Leu Thr Leu Ser Leu Leu Glu Gln Pro Pro Leu Glu 
385                 390                 395                 400 


Ala Glu Glu Pro Pro Asp Gly Gly Thr Asp Gly Lys Ala Gln Leu Val 
                405                 410                 415     


Val His Ser Ala Phe Glu Gln Asp Val Glu Glu Leu Asp Arg Ala Leu 
            420                 425                 430         


Arg Ala Ala Leu Glu Val His Val Gln Glu Glu Thr Val Gly Pro Trp 
        435                 440                 445             


Arg Arg Thr Leu Pro Ala Glu Leu Arg Ala Arg Leu Glu Arg Cys His 
    450                 455                 460                 


Gly Val Ser Val Ala Leu Arg Gly Asp Cys Thr Ile Leu Arg Gly Phe 
465                 470                 475                 480 


Gly Ala His Pro Ala Arg Ala Ala Arg His Leu Val Ala Leu Leu Ala 
                485                 490                 495     


Gly Pro Trp Asp Gln Ser Leu Ala Phe Pro Leu Ala Ala Ser Gly Pro 
            500                 505                 510         


Thr Leu Ala Gly Gln Thr Leu Lys Gly Pro Trp Asn Asn Leu Glu Arg 
        515                 520                 525             


Leu Ala Glu Asn Thr Gly Glu Phe Gln Glu Val Val Arg Ala Phe Tyr 
    530                 535                 540                 


Asp Thr Leu Asp Ala Ala Arg Ser Ser Ile Arg Val Val Arg Val Glu 
545                 550                 555                 560 


Arg Val Ser His Pro Leu Leu Gln Gln Gln Tyr Glu Leu Tyr Arg Glu 
                565                 570                 575     


Arg Leu Leu Gln Arg Cys Glu Arg Arg Pro Val Glu Gln Val Leu Tyr 
            580                 585                 590         


His Gly Thr Thr Ala Pro Ala Val Pro Asp Ile Cys Ala His Gly Phe 
        595                 600                 605             


Asn Arg Ser Phe Cys Gly Arg Asn Ala Thr Val Tyr Gly Lys Gly Val 
    610                 615                 620                 


Tyr Phe Ala Arg Arg Ala Ser Leu Ser Val Gln Asp Arg Tyr Ser Pro 
625                 630                 635                 640 


Pro Asn Ala Asp Gly His Lys Ala Val Phe Val Ala Arg Val Leu Thr 
                645                 650                 655     


Gly Asp Tyr Gly Gln Gly Arg Arg Gly Leu Arg Ala Pro Pro Leu Arg 
            660                 665                 670         


Gly Pro Gly His Val Leu Leu Arg Tyr Asp Ser Ala Val Asp Cys Ile 
        675                 680                 685             


Cys Gln Pro Ser Ile Phe Val Ile Phe His Asp Thr Gln Ala Leu Pro 
    690                 695                 700                 


Thr His Leu Ile Thr Cys Glu His Val Pro Arg Ala Ser Pro Asp Asp 
705                 710                 715                 720 


Pro Ser Gly Leu Pro Gly Arg Ser Pro Asp Thr 
                725                 730     


<210> 8666
<211> 360
<212> PRT
<213> Homo sapiens

<400> 8666
Met Gln Val Tyr Glu Gly Leu Asp Ile Ile Thr Asn Lys Val Ser Ala 
1               5                   10                  15      


Gln Glu Gln Arg Ile Cys Arg His His Met Ile Ser Phe Val Asp Pro 
            20                  25                  30          


Leu Val Thr Asn Tyr Thr Val Val Asp Phe Arg Asn Arg Ala Thr Ala 
        35                  40                  45              


Leu Ile Tyr Leu Pro Glu Thr Lys Phe Leu Leu Leu Trp Glu Glu Pro 
    50                  55                  60                  


Ile Ile Thr Leu Asn Leu Cys Ser Gly Lys Phe Leu Ser Ile Pro Arg 
65                  70                  75                  80  


Ser Leu Gln Val Phe Glu Glu Thr Gly Ile Ser His Ser Glu Phe Leu 
                85                  90                  95      


His Arg Gln His Thr Glu Glu Gly Gly Gly Pro Leu Gly Gly Pro Leu 
            100                 105                 110         


Lys Phe Ser Asn Pro Cys Ile Leu Trp Leu His Ala Asp Gln Ala Val 
        115                 120                 125             


Leu Asp Glu Arg Leu Asp Lys Arg Val Asp Asp Met Leu Ala Ala Gly 
    130                 135                 140                 


Leu Leu Glu Glu Leu Arg Asp Phe His Arg Arg Tyr Asn Gln Lys Asn 
145                 150                 155                 160 


Val Ser Glu Asn Ser Gln Asp Tyr Gln His Gly Ile Phe Gln Ser Ile 
                165                 170                 175     


Gly Phe Lys Glu Phe His Glu Tyr Leu Ile Thr Glu Gly Lys Cys Thr 
            180                 185                 190         


Leu Glu Thr Ser Asn Gln Leu Leu Lys Lys Gly Ile Glu Ala Leu Lys 
        195                 200                 205             


Gln Val Thr Lys Arg Tyr Ala Arg Lys Gln Asn Arg Trp Val Lys Asn 
    210                 215                 220                 


Arg Phe Leu Ser Arg Pro Gly Pro Ile Val Pro Pro Val Tyr Gly Leu 
225                 230                 235                 240 


Glu Val Ser Asp Val Ser Lys Trp Glu Glu Ser Val Leu Glu Pro Ala 
                245                 250                 255     


Leu Glu Ile Val Gln Ser Phe Ile Gln Gly His Lys Pro Thr Ala Thr 
            260                 265                 270         


Pro Ile Lys Met Pro Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr His 
        275                 280                 285             


Leu Cys Asp Leu Cys Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp Ala 
    290                 295                 300                 


Ala His Ile Lys Ser Lys Ser His Leu Asn Gln Leu Lys Lys Arg Arg 
305                 310                 315                 320 


Arg Leu Asp Ser Asp Ala Val Asn Thr Ile Glu Ser Gln Ser Val Ser 
                325                 330                 335     


Pro Asp His Asn Lys Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln Asn 
            340                 345                 350         


Asp Gln Glu Leu Lys Cys Ser Val 
        355                 360 


<210> 8667
<211> 275
<212> PRT
<213> Homo sapiens

<400> 8667
Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210> 8668
<211> 563
<212> PRT
<213> Homo sapiens

<400> 8668
Met Glu Thr Ala Lys Gln Lys Ala Leu Glu Val Ala Asn Arg Leu Tyr 
1               5                   10                  15      


Gln Lys Asp Leu Arg Ala Pro Asp Val Val Ile Gly Ala Asp Thr Ile 
            20                  25                  30          


Val Thr Val Gly Gly Leu Ile Leu Glu Lys Pro Val Asp Lys Gln Asp 
        35                  40                  45              


Ala Tyr Arg Met Leu Ser Arg Leu Ser Gly Arg Glu His Ser Val Phe 
    50                  55                  60                  


Thr Gly Val Ala Ile Val His Cys Ser Ser Lys Asp His Gln Leu Asp 
65                  70                  75                  80  


Thr Arg Val Ser Glu Phe Tyr Glu Glu Thr Lys Val Lys Phe Ser Glu 
                85                  90                  95      


Leu Ser Glu Glu Leu Leu Trp Glu Tyr Val His Ser Gly Glu Pro Met 
            100                 105                 110         


Asp Lys Ala Gly Gly Tyr Gly Ile Gln Ala Leu Gly Gly Met Leu Val 
        115                 120                 125             


Glu Ser Val His Gly Asp Phe Leu Asn Val Val Gly Phe Pro Leu Asn 
    130                 135                 140                 


His Phe Cys Lys Gln Leu Val Lys Leu Tyr Tyr Pro Pro Arg Pro Glu 
145                 150                 155                 160 


Asp Leu Arg Arg Ser Val Lys His Asp Ser Ile Pro Ala Ala Asp Thr 
                165                 170                 175     


Phe Glu Asp Leu Ser Asp Val Glu Gly Gly Gly Ser Glu Pro Thr Gln 
            180                 185                 190         


Arg Asp Ala Gly Ser Arg Asp Glu Lys Ala Glu Ala Gly Glu Ala Gly 
        195                 200                 205             


Gln Ala Thr Ala Glu Ala Glu Cys His Arg Thr Arg Glu Thr Leu Pro 
    210                 215                 220                 


Pro Phe Pro Thr Arg Leu Leu Glu Leu Ile Glu Gly Phe Met Leu Ser 
225                 230                 235                 240 


Lys Gly Leu Leu Thr Ala Cys Lys Leu Lys Val Phe Asp Leu Leu Lys 
                245                 250                 255     


Asp Glu Ala Pro Gln Lys Ala Ala Asp Ile Ala Ser Lys Val Asp Ala 
            260                 265                 270         


Ser Ala Cys Gly Met Glu Arg Leu Leu Asp Ile Cys Ala Ala Met Gly 
        275                 280                 285             


Leu Leu Glu Lys Thr Glu Gln Gly Tyr Ser Asn Thr Glu Thr Ala Asn 
    290                 295                 300                 


Val Tyr Leu Ala Ser Asp Gly Glu Tyr Ser Leu His Gly Phe Ile Met 
305                 310                 315                 320 


His Asn Asn Asp Leu Thr Trp Asn Leu Phe Thr Tyr Leu Glu Phe Ala 
                325                 330                 335     


Ile Arg Glu Gly Thr Asn Gln His His Arg Ala Leu Gly Lys Lys Ala 
            340                 345                 350         


Glu Asp Leu Phe Gln Asp Ala Tyr Tyr Gln Ser Pro Glu Thr Arg Leu 
        355                 360                 365             


Arg Phe Met Arg Ala Met His Gly Met Thr Lys Leu Thr Ala Cys Gln 
    370                 375                 380                 


Val Ala Thr Ala Phe Asn Leu Ser Arg Phe Ser Ser Ala Cys Asp Val 
385                 390                 395                 400 


Gly Gly Cys Thr Gly Ala Leu Ala Arg Glu Leu Ala Arg Glu Tyr Pro 
                405                 410                 415     


Arg Met Gln Val Thr Val Phe Asp Leu Pro Asp Ile Ile Glu Leu Ala 
            420                 425                 430         


Ala His Phe Gln Pro Pro Gly Pro Gln Ala Val Gln Ile His Phe Ala 
        435                 440                 445             


Ala Gly Asp Phe Phe Arg Asp Pro Leu Pro Ser Ala Glu Leu Tyr Val 
    450                 455                 460                 


Leu Cys Arg Ile Leu His Asp Trp Pro Asp Asp Lys Val His Lys Leu 
465                 470                 475                 480 


Leu Ser Arg Val Ala Glu Ser Cys Lys Pro Gly Ala Gly Leu Leu Leu 
                485                 490                 495     


Val Glu Thr Leu Leu Asp Glu Glu Lys Arg Val Ala Gln Arg Ala Leu 
            500                 505                 510         


Met Gln Ser Leu Asn Met Leu Val Gln Thr Glu Gly Lys Glu Arg Ser 
        515                 520                 525             


Leu Gly Glu Tyr Gln Cys Leu Leu Glu Leu His Gly Phe His Gln Val 
    530                 535                 540                 


Gln Val Val His Leu Gly Gly Val Leu Asp Ala Ile Leu Ala Thr Lys 
545                 550                 555                 560 


Val Ala Pro 
            


<210> 8669
<211> 275
<212> PRT
<213> Homo sapiens

<400> 8669
Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210> 8670
<211> 332
<212> PRT
<213> Homo sapiens

<400> 8670
Met Glu Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly 
1               5                   10                  15      


Pro Leu Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys 
            20                  25                  30          


Gly Leu Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys 
        35                  40                  45              


Ala Ala Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu Ala Asp 
    50                  55                  60                  


Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr 
65                  70                  75                  80  


Phe Val Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser 
                85                  90                  95      


Ala Tyr Asp Phe Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile 
            100                 105                 110         


Glu Leu Ala Lys Gly Glu Pro Pro Asn Ser Asp Leu His Pro Met Arg 
        115                 120                 125             


Val Leu Phe Leu Ile Pro Lys Asn Ser Pro Pro Thr Leu Glu Gly Gln 
    130                 135                 140                 


His Ser Lys Pro Phe Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Asp 
145                 150                 155                 160 


Pro Arg Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile 
                165                 170                 175     


Thr Arg Tyr Thr Lys Lys Thr Ser Phe Leu Thr Glu Leu Ile Asp Arg 
            180                 185                 190         


Tyr Lys Arg Trp Lys Ser Glu Gly His Gly Glu Glu Ser Ser Ser Glu 
        195                 200                 205             


Asp Ser Asp Ile Asp Gly Glu Ala Glu Asp Gly Glu Gln Gly Pro Ile 
    210                 215                 220                 


Trp Thr Phe Pro Pro Thr Ile Arg Pro Ser Pro His Ser Lys Leu His 
225                 230                 235                 240 


Lys Gly Thr Ala Leu His Ser Ser Gln Lys Pro Ala Glu Pro Val Lys 
                245                 250                 255     


Arg Gln Pro Arg Ser Gln Cys Leu Ser Thr Leu Val Arg Pro Val Phe 
            260                 265                 270         


Gly Glu Leu Lys Glu Lys His Lys Gln Ser Gly Gly Ser Val Gly Ala 
        275                 280                 285             


Leu Glu Glu Leu Glu Asn Ala Phe Ser Leu Ala Glu Glu Ser Cys Pro 
    290                 295                 300                 


Gly Ile Ser Asp Lys Leu Met Val His Leu Val Glu Arg Val Gln Arg 
305                 310                 315                 320 


Phe Ser His Asn Arg Asn His Leu Thr Ser Thr Arg 
                325                 330         


<210> 8671
<211> 92
<212> PRT
<213> Homo sapiens

<400> 8671
Met Asn Phe Thr Pro Thr His Thr Pro Val Cys Arg Lys Arg Thr Val 
1               5                   10                  15      


Val Ser Lys Arg Gly Val Ala Val Ser Gly Pro Thr Lys Arg Arg Gly 
            20                  25                  30          


Met Ala Asp Ser Leu Glu Ser Thr Pro Leu Pro Ser Pro Glu Asp Arg 
        35                  40                  45              


Leu Ala Lys Leu His Pro Ser Lys Glu Leu Leu Glu Tyr Tyr Gln Lys 
    50                  55                  60                  


Lys Met Ala Glu Cys Glu Ala Glu Asn Glu Asp Leu Leu Lys Lys Leu 
65                  70                  75                  80  


Glu Leu Tyr Lys Glu Ala Cys Glu Gly Gln His Lys 
                85                  90          


<210> 8672
<211> 142
<212> PRT
<213> Homo sapiens

<400> 8672
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg Arg His Phe Thr Ile Asp Asp Phe Glu Ile 
65                  70                  75                  80  


Gly Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg 
                85                  90                  95      


Glu Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser 
            100                 105                 110         


Gln Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu 
        115                 120                 125             


Ile Gln Ala His Leu Gln Ser Trp Arg Ser Trp Gln Met Leu 
    130                 135                 140         


<210> 8673
<211> 166
<212> PRT
<213> Homo sapiens

<400> 8673
Met Asp Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu 
1               5                   10                  15      


Arg Asp Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu 
            20                  25                  30          


Ala Pro Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp 
        35                  40                  45              


Leu Ser Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro 
    50                  55                  60                  


Gly Gly Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp 
                85                  90                  95      


Pro Ser Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro 
            100                 105                 110         


Ser Glu Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ile 
        115                 120                 125             


Ser Cys Ser Ser Asn His Thr Phe Gly Asp Phe Glu Gly Ser Gly Asp 
    130                 135                 140                 


Thr Gln Pro Pro Gln Thr Pro Pro Ile Leu Arg Gly Ser Arg Cys Thr 
145                 150                 155                 160 


Pro Trp Gly Thr Pro Val 
                165     


<210> 8674
<211> 490
<212> PRT
<213> Homo sapiens

<400> 8674
Met Gln Ser Leu Asp Asp Ala Thr Lys Gln Leu Asp Phe Thr Arg Lys 
1               5                   10                  15      


Thr Leu Ala Glu Lys Lys Gln Glu Leu Asp Lys Leu Arg Asn Glu Trp 
            20                  25                  30          


Ala Ser His Thr Ala Ala Leu Thr Asn Lys His Ser Gln Glu Leu Thr 
        35                  40                  45              


Asn Glu Lys Glu Lys Ala Leu Gln Ala Gln Val Gln Tyr Gln Gln Gln 
    50                  55                  60                  


His Glu Gln Gln Lys Lys Asp Leu Glu Ile Leu His Gln Gln Asn Ile 
65                  70                  75                  80  


His Gln Leu Gln Asn Arg Leu Ser Glu Leu Glu Ala Ala Asn Lys Asp 
                85                  90                  95      


Leu Thr Glu Arg Lys Tyr Lys Gly Asp Ser Thr Ile Arg Glu Leu Lys 
            100                 105                 110         


Ala Lys Leu Ser Gly Val Glu Glu Glu Leu Gln Arg Thr Lys Gln Glu 
        115                 120                 125             


Val Leu Ser Leu Arg Arg Glu Asn Ser Thr Leu Asp Val Glu Cys His 
    130                 135                 140                 


Glu Lys Glu Lys His Val Asn Gln Leu Gln Thr Lys Val Ala Val Leu 
145                 150                 155                 160 


Glu Gln Glu Ile Lys Asp Lys Asp Gln Leu Val Leu Arg Thr Lys Glu 
                165                 170                 175     


Ala Phe Asp Thr Ile Gln Glu Gln Lys Val Val Leu Glu Glu Asn Gly 
            180                 185                 190         


Glu Lys Asn Gln Val Gln Leu Gly Lys Leu Glu Ala Thr Ile Lys Ser 
        195                 200                 205             


Leu Ser Ala Glu Leu Leu Lys Ala Asn Glu Ile Ile Lys Lys Leu Gln 
    210                 215                 220                 


Gly Asp Leu Lys Thr Leu Met Gly Lys Leu Lys Leu Lys Asn Thr Val 
225                 230                 235                 240 


Thr Ile Gln Gln Glu Lys Leu Leu Ala Glu Lys Glu Glu Lys Leu Gln 
                245                 250                 255     


Lys Glu Gln Lys Glu Leu Gln Asp Val Gly Gln Ser Leu Arg Ile Lys 
            260                 265                 270         


Glu Gln Glu Val Cys Lys Leu Gln Glu Gln Leu Glu Ala Thr Val Lys 
        275                 280                 285             


Lys Leu Glu Glu Ser Lys Gln Leu Leu Lys Asn Asn Glu Lys Leu Ile 
    290                 295                 300                 


Thr Trp Leu Asn Lys Glu Leu Asn Glu Asn Gln Leu Val Arg Lys Gln 
305                 310                 315                 320 


Asp Val Leu Gly Pro Ser Thr Thr Pro Pro Ala His Ser Ser Ser Asn 
                325                 330                 335     


Thr Ile Arg Ser Gly Ile Ser Pro Asn Leu Asn Val Val Asp Gly Arg 
            340                 345                 350         


Leu Thr Tyr Pro Thr Cys Gly Ile Gly Tyr Pro Val Ser Ser Ala Phe 
        355                 360                 365             


Ala Phe Gln Asn Thr Phe Pro His Ser Ile Ser Ala Lys Asn Thr Ser 
    370                 375                 380                 


His Pro Gly Ser Gly Thr Lys Val Gln Phe Asn Leu Gln Phe Thr Lys 
385                 390                 395                 400 


Pro Asn Ala Ser Leu Gly Asp Val Gln Ser Gly Ala Thr Ile Ser Met 
                405                 410                 415     


Pro Cys Ser Thr Asp Lys Glu Asn Gly Glu Asn Val Gly Leu Glu Ser 
            420                 425                 430         


Lys Tyr Leu Lys Lys Arg Glu Asp Ser Ile Pro Leu Arg Gly Leu Ser 
        435                 440                 445             


Gln Asn Leu Phe Ser Asn Ser Asp His Gln Arg Asp Gly Thr Leu Gly 
    450                 455                 460                 


Ala Leu His Thr Ser Ser Lys Pro Thr Ala Leu Pro Ser Ala Ser Ser 
465                 470                 475                 480 


Ala Tyr Phe Pro Gly Gln Leu Pro Asn Ser 
                485                 490 


<210> 8675
<211> 1004
<212> PRT
<213> Homo sapiens

<400> 8675
Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Lys 
    850                 855                 860                 


Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr Leu 
865                 870                 875                 880 


Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu Leu 
                885                 890                 895     


Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro Thr 
            900                 905                 910         


Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser Ala 
        915                 920                 925             


Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu Arg 
    930                 935                 940                 


Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp Leu 
945                 950                 955                 960 


Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu Trp 
                965                 970                 975     


Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala Ala 
            980                 985                 990         


Leu Arg Val Thr Lys Pro Tyr Leu  Asp Ile Gly Cys 
        995                 1000                 


<210> 8676
<211> 838
<212> PRT
<213> Homo sapiens

<400> 8676
Met Thr Gly Ala Glu Ile Glu Pro Ser Ala Gln Ala Lys Pro Glu Lys 
1               5                   10                  15      


Lys Ala Gly Glu Glu Val Ile Ala Gly Pro Glu Arg Glu Asn Asp Val 
            20                  25                  30          


Pro Leu Val Val Arg Pro Lys Val Arg Thr Gln Ala Thr Thr Gly Ala 
        35                  40                  45              


Arg Pro Lys Thr Glu Thr Lys Ser Val Pro Ala Ala Arg Pro Lys Thr 
    50                  55                  60                  


Glu Ala Gln Ala Met Ser Gly Ala Arg Pro Lys Thr Glu Val Gln Val 
65                  70                  75                  80  


Met Gly Gly Ala Arg Pro Lys Thr Glu Ala Gln Gly Ile Thr Gly Ala 
                85                  90                  95      


Arg Pro Lys Thr Asp Ala Arg Ala Val Gly Gly Ala Arg Ser Lys Thr 
            100                 105                 110         


Asp Ala Lys Ala Ile Pro Gly Ala Arg Pro Lys Asp Glu Ala Gln Ala 
        115                 120                 125             


Trp Ala Gln Ser Glu Phe Gly Thr Glu Ala Val Ser Gln Ala Glu Gly 
    130                 135                 140                 


Val Ser Gln Thr Asn Ala Val Ala Trp Pro Leu Ala Thr Ala Glu Ser 
145                 150                 155                 160 


Gly Ser Val Thr Lys Ser Lys Gly Leu Ser Met Asp Arg Glu Leu Val 
                165                 170                 175     


Asn Val Asp Ala Glu Thr Phe Pro Gly Thr Gln Gly Gln Lys Gly Ile 
            180                 185                 190         


Gln Pro Trp Phe Gly Pro Gly Glu Glu Thr Asn Met Gly Ser Trp Cys 
        195                 200                 205             


Tyr Ser Arg Pro Arg Ala Arg Glu Glu Ala Ser Asn Glu Ser Gly Phe 
    210                 215                 220                 


Trp Ser Ala Asp Glu Thr Ser Thr Ala Ser Ser Phe Trp Thr Gly Glu 
225                 230                 235                 240 


Glu Thr Ser Val Arg Ser Trp Pro Arg Glu Glu Ser Asn Thr Arg Ser 
                245                 250                 255     


Arg His Arg Ala Lys His Gln Thr Asn Pro Arg Ser Arg Pro Arg Ser 
            260                 265                 270         


Lys Gln Glu Ala Tyr Val Asp Ser Trp Ser Gly Ser Glu Asp Glu Ala 
        275                 280                 285             


Ser Asn Pro Phe Ser Phe Trp Val Gly Glu Asn Thr Asn Asn Leu Phe 
    290                 295                 300                 


Arg Pro Arg Val Arg Glu Glu Ala Asn Ile Arg Ser Lys Leu Arg Thr 
305                 310                 315                 320 


Asn Arg Glu Asp Cys Phe Glu Ser Glu Ser Glu Asp Glu Phe Tyr Lys 
                325                 330                 335     


Gln Ser Trp Val Leu Pro Gly Glu Glu Ala Asn Ser Arg Phe Arg His 
            340                 345                 350         


Arg Asp Lys Glu Asp Pro Asn Thr Ala Leu Lys Leu Arg Ala Gln Lys 
        355                 360                 365             


Asp Val Asp Ser Asp Arg Val Lys Gln Glu Pro Arg Phe Glu Glu Glu 
    370                 375                 380                 


Val Ile Ile Gly Ser Trp Phe Trp Ala Glu Lys Glu Ala Ser Leu Glu 
385                 390                 395                 400 


Gly Gly Ala Ser Ala Ile Cys Glu Ser Glu Pro Gly Thr Glu Glu Gly 
                405                 410                 415     


Ala Ile Gly Gly Ser Ala Tyr Trp Ala Glu Glu Lys Ser Ser Leu Gly 
            420                 425                 430         


Ala Val Ala Arg Glu Glu Ala Lys Pro Glu Ser Glu Glu Glu Ala Ile 
        435                 440                 445             


Phe Gly Ser Trp Phe Trp Asp Arg Asp Glu Ala Cys Phe Asp Leu Asn 
    450                 455                 460                 


Pro Cys Pro Val Tyr Lys Val Ser Asp Arg Phe Arg Asp Ala Ala Glu 
465                 470                 475                 480 


Glu Leu Asn Ala Ser Ser Arg Pro Gln Thr Trp Asp Glu Val Thr Val 
                485                 490                 495     


Glu Phe Lys Pro Gly Leu Phe His Gly Val Gly Phe Arg Ser Thr Ser 
            500                 505                 510         


Pro Phe Gly Ile Pro Glu Glu Ala Ser Glu Met Leu Glu Ala Lys Pro 
        515                 520                 525             


Lys Asn Leu Glu Leu Ser Pro Glu Gly Glu Glu Gln Glu Ser Leu Leu 
    530                 535                 540                 


Gln Pro Asp Gln Pro Ser Pro Glu Phe Thr Phe Gln Tyr Asp Pro Ser 
545                 550                 555                 560 


Tyr Arg Ser Val Arg Glu Ile Arg Glu His Leu Arg Ala Arg Glu Ser 
                565                 570                 575     


Ala Glu Ser Glu Ser Trp Ser Cys Ser Cys Ile Gln Cys Glu Leu Lys 
            580                 585                 590         


Ile Gly Ser Glu Glu Phe Glu Glu Phe Leu Leu Leu Met Asp Lys Ile 
        595                 600                 605             


Arg Asp Pro Phe Ile His Glu Ile Ser Lys Ile Ala Met Gly Met Arg 
    610                 615                 620                 


Ser Ala Ser Gln Phe Thr Arg Asp Phe Ile Arg Asp Ser Gly Val Val 
625                 630                 635                 640 


Ser Leu Ile Glu Thr Leu Leu Asn Tyr Pro Ser Ser Arg Val Arg Thr 
                645                 650                 655     


Ser Phe Leu Glu Asn Met Ile His Met Ala Pro Pro Tyr Pro Asn Leu 
            660                 665                 670         


Asn Met Ile Glu Thr Phe Ile Cys Gln Val Cys Glu Glu Thr Leu Ala 
        675                 680                 685             


His Ser Val Asp Ser Leu Glu Gln Leu Thr Gly Ile Arg Met Leu Arg 
    690                 695                 700                 


His Leu Thr Met Thr Ile Asp Tyr His Thr Leu Ile Ala Asn Tyr Met 
705                 710                 715                 720 


Ser Gly Phe Leu Ser Leu Leu Thr Thr Ala Asn Ala Arg Thr Lys Phe 
                725                 730                 735     


His Val Leu Lys Met Leu Leu Asn Leu Ser Glu Asn Pro Ala Val Ala 
            740                 745                 750         


Lys Lys Leu Phe Ser Ala Lys Ala Leu Ser Ile Phe Val Gly Leu Phe 
        755                 760                 765             


Asn Ile Glu Glu Thr Asn Asp Asn Ile Gln Ile Val Ile Lys Met Phe 
    770                 775                 780                 


Gln Asn Ile Ser Asn Ile Ile Lys Ser Gly Lys Met Ser Leu Ile Asp 
785                 790                 795                 800 


Asp Asp Phe Ser Leu Glu Pro Leu Ile Ser Ala Phe Arg Glu Phe Glu 
                805                 810                 815     


Glu Leu Ala Lys Gln Leu Gln Ala Gln Ile Asp Asn Gln Asn Asp Pro 
            820                 825                 830         


Glu Val Gly Gln Gln Ser 
        835             


<210> 8677
<211> 54
<212> PRT
<213> Homo sapiens

<400> 8677
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala Gly 
    50                  


<210> 8678
<211> 422
<212> PRT
<213> Homo sapiens

<400> 8678
Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg 
1               5                   10                  15      


Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala 
            20                  25                  30          


Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu 
        35                  40                  45              


Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro 
    50                  55                  60                  


Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln 
65                  70                  75                  80  


Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu 
                85                  90                  95      


Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu 
            100                 105                 110         


Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His 
        115                 120                 125             


Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His 
    130                 135                 140                 


Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly 
                165                 170                 175     


Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro 
            180                 185                 190         


Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp 
        195                 200                 205             


Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala 
    210                 215                 220                 


Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile 
225                 230                 235                 240 


Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu 
                245                 250                 255     


Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly 
            260                 265                 270         


Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu 
        275                 280                 285             


Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile 
    290                 295                 300                 


Gln Asn Met Pro Asn Val Arg Asp His Asp Ala Ser Val Tyr Leu Arg 
305                 310                 315                 320 


Leu Gln Gly Asp Ala Leu Ser Val Gly Gly Tyr Glu Ala Asn Pro Ile 
                325                 330                 335     


Phe Trp Glu Glu Val Ser Asp Lys Phe Ala Phe Gly Leu Phe Asp Leu 
            340                 345                 350         


Asp Trp Glu Val Phe Thr Gln His Ile Glu Gly Ala Ile Asn Arg Val 
        355                 360                 365             


Pro Val Leu Glu Lys Thr Gly Ile Lys Ser Thr Val Cys Gly Pro Glu 
    370                 375                 380                 


Ser Phe Thr Pro Asp His Lys Pro Leu Met Gly Glu Ala Pro Glu Leu 
385                 390                 395                 400 


Arg Gly Phe Phe Leu Gly Cys Gly Phe Asn Ser Ala Gly Glu Ser Gly 
                405                 410                 415     


Gln Ala Leu Leu Ala Pro 
            420         


<210> 8679
<211> 108
<212> PRT
<213> Homo sapiens

<400> 8679
Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95      


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr 
            100                 105             


<210> 8680
<211> 715
<212> PRT
<213> Homo sapiens

<400> 8680
Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Val Val Ser Glu Glu Lys Ser Leu Met Phe Ile Arg Pro 
            100                 105                 110         


Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro Glu Leu Gly Tyr 
        115                 120                 125             


Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg Tyr Asp Leu Asn 
    130                 135                 140                 


Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu Glu Phe Lys Glu 
145                 150                 155                 160 


Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu Arg Val Leu Glu 
                165                 170                 175     


Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His Ala Ile Glu Thr 
            180                 185                 190         


Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val Val Cys Asp Val 
        195                 200                 205             


Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met Val Phe Cys Asp 
    210                 215                 220                 


Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val 
225                 230                 235                 240 


Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu Gly Val Gln Pro 
                245                 250                 255     


Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met Lys Pro Thr Arg 
            260                 265                 270         


Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu Trp Ile Pro Glu 
        275                 280                 285             


Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile Thr Lys Val Ser 
    290                 295                 300                 


His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser Leu Cys Asn Glu 
305                 310                 315                 320 


Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn Cys Arg Thr Ala 
                325                 330                 335     


Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu Met Lys Thr Ile 
            340                 345                 350         


Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr Cys Pro Lys His 
        355                 360                 365             


Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys Gly Ala Ala Gln 
    370                 375                 380                 


Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro Leu Glu Pro Phe 
385                 390                 395                 400 


Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg Val Ser Val Arg 
                405                 410                 415     


Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr Thr Phe Val Asn 
            420                 425                 430         


Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu Glu Val Val Asp 
        435                 440                 445             


Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val Asn Phe Asn Lys 
    450                 455                 460                 


Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn Leu Ala Lys Arg 
465                 470                 475                 480 


Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe Thr His Leu Arg 
                485                 490                 495     


Gln Asp Leu Glu Arg Val Arg Asn Leu Thr Tyr Met Val Thr Arg Arg 
            500                 505                 510         


Glu Lys Ile Lys Arg Ser Val Cys Lys Val Gln Glu Gln Ile Phe Asn 
        515                 520                 525             


Leu Tyr Thr Lys Leu Leu Glu Gln Glu Arg Val Ser Gly Val Pro Ser 
    530                 535                 540                 


Ser Cys Ser Ser Ser Ser Leu Glu Asn Met Leu Leu Phe Asn Ser Pro 
545                 550                 555                 560 


Ser Val Gly Pro Asp Ala Pro Lys Ile Glu Asp Leu Lys Trp His Ser 
                565                 570                 575     


Ala Phe Phe Arg Lys Gln Met Gly Thr Ser Leu Val His Ser Leu Lys 
            580                 585                 590         


Lys Pro His Lys Arg Asp Pro Leu Gln Asn Ser Pro Gly Ser Glu Gly 
        595                 600                 605             


Lys Thr Leu Leu Lys Gln Pro Asp Leu Cys Gly Arg Arg Glu Gly Met 
    610                 615                 620                 


Val Val Pro Glu Ser Phe Leu Gly Leu Glu Lys Thr Phe Ala Glu Ala 
625                 630                 635                 640 


Arg Leu Ile Ser Ala Gln Gln Lys Asn Gly Val Val Met Pro Asp His 
                645                 650                 655     


Gly Lys Arg Arg Asp Asn Arg Phe His Cys Asp Leu Ile Lys Gly Asp 
            660                 665                 670         


Leu Lys Asp Lys Ser Phe Lys Gln Ser His Lys Pro Leu Arg Ser Thr 
        675                 680                 685             


Asp Val Ser Gln Arg His Leu Asp Asn Thr Arg Ala Ala Ala Ile Trp 
    690                 695                 700                 


Arg Phe Arg Val Ile Trp Gln Gly Pro Ala Ala 
705                 710                 715 


<210> 8681
<211> 53
<212> PRT
<213> Homo sapiens

<400> 8681
Met Gly Arg Arg Ser Thr Ser Ser Thr Lys Ser Gly Lys Phe Met Asn 
1               5                   10                  15      


Pro Thr Asp Gln Ala Arg Lys Glu Ala Arg Lys Arg Glu Leu Lys Lys 
            20                  25                  30          


Asn Lys Lys Gln Arg Met Met Val Arg Ala Ala Val Leu Lys Met Lys 
        35                  40                  45              


Asp Pro Lys Gln Ile 
    50              


<210> 8682
<211> 344
<212> PRT
<213> Homo sapiens

<400> 8682
Met Thr Thr Arg Ser Val Leu Asp Val Glu Thr Phe Val Ala Asp Ile 
1               5                   10                  15      


Leu Lys Gly Glu Asn Leu Ser Lys Lys Ala Lys Glu Lys Arg Glu Ser 
            20                  25                  30          


Leu Ile Lys Lys Ile Lys Asp Val Lys Ser Ile Tyr Leu Gln Glu Phe 
        35                  40                  45              


Gln Asp Lys Gly Asp Ala Glu Asp Gly Glu Glu Tyr Asp Asp Pro Phe 
    50                  55                  60                  


Ala Gly Pro Pro Asp Thr Ile Ser Leu Ala Ser Glu Arg Tyr Asp Lys 
65                  70                  75                  80  


Asp Asp Glu Ala Pro Ser Asp Gly Ala Gln Phe Pro Pro Ile Ala Ala 
                85                  90                  95      


Gln Asp Leu Pro Phe Val Leu Lys Ala Gly Tyr Leu Glu Lys Arg Arg 
            100                 105                 110         


Lys Asp His Ser Phe Leu Gly Phe Glu Trp Gln Lys Arg Trp Cys Ala 
        115                 120                 125             


Leu Ser Lys Thr Val Phe Tyr Tyr Tyr Gly Ser Asp Lys Asp Lys Gln 
    130                 135                 140                 


Gln Lys Gly Glu Phe Ala Ile Asp Gly Tyr Ser Val Arg Met Asn Asn 
145                 150                 155                 160 


Thr Leu Arg Lys Asp Gly Lys Lys Asp Cys Cys Phe Glu Ile Ser Ala 
                165                 170                 175     


Pro Asp Lys Arg Ile Tyr Gln Phe Thr Ala Ala Ser Pro Lys Asp Ala 
            180                 185                 190         


Glu Glu Trp Val Gln Gln Leu Lys Phe Val Leu Gln Asp Met Glu Ser 
        195                 200                 205             


Asp Ile Ile Pro Glu Asp Tyr Asp Glu Arg Gly Glu Leu Tyr Asp Asp 
    210                 215                 220                 


Val Asp His Pro Leu Pro Ile Ser Asn Pro Leu Thr Ser Ser Gln Pro 
225                 230                 235                 240 


Ile Asp Asp Glu Ile Tyr Glu Glu Leu Pro Glu Glu Glu Glu Asp Ser 
                245                 250                 255     


Ala Pro Val Lys Val Glu Glu Gln Arg Lys Met Ser Gln Asp Ser Val 
            260                 265                 270         


His His Thr Ser Gly Asp Lys Ser Thr Asp Tyr Ala Asn Phe Tyr Gln 
        275                 280                 285             


Gly Leu Trp Asp Cys Thr Gly Ala Phe Ser Asp Glu Leu Ser Phe Lys 
    290                 295                 300                 


Arg Gly Asp Val Ile Tyr Ile Leu Ser Lys Glu Tyr Asn Arg Tyr Gly 
305                 310                 315                 320 


Trp Trp Val Gly Glu Met Lys Gly Ala Ile Gly Leu Val Pro Lys Ala 
                325                 330                 335     


Tyr Ile Met Glu Met Tyr Asp Ile 
            340                 


<210> 8683
<211> 955
<212> PRT
<213> Homo sapiens

<400> 8683
Met Glu Val Gly Ser Glu Glu Glu Lys Trp Glu Lys Leu Asp Ala Glu 
1               5                   10                  15      


Phe Asp His Phe Val Val Asp Met Lys Pro Phe Val Leu Lys Leu Pro 
            20                  25                  30          


His Arg Thr Glu Arg Gln Arg Cys Ala Leu Trp Ile Arg Lys Leu Cys 
        35                  40                  45              


Glu Pro Ser Gly Thr Gly Ala Gly Ile Met Gly Arg Lys Asn Arg Asn 
    50                  55                  60                  


Leu Tyr Ala Lys Leu Leu Leu His Met Leu Lys Arg Gly Ala Leu Glu 
65                  70                  75                  80  


Gly Pro Phe Thr His Arg Pro Glu Pro Gly Thr Leu Lys Ile Leu Pro 
                85                  90                  95      


Ser Tyr Met Ser Ile Tyr Phe Asp Glu Pro Asn Pro Ala Arg Ala Lys 
            100                 105                 110         


Gly Ser Ser Pro Glu Gly Leu Pro Ala Trp Val Leu Gly Glu Leu Glu 
        115                 120                 125             


Thr Ser Glu His Lys Leu Asn Glu Ser Trp Lys Leu Ser Ser Gly Glu 
    130                 135                 140                 


Asp Asn Thr Leu Val Gln Ser Pro Thr Asp Val Tyr Ser Arg Glu Gln 
145                 150                 155                 160 


Tyr Thr Gly Lys Leu Arg Val Arg Ser His Ser Leu Ser Pro Thr His 
                165                 170                 175     


Arg Glu Asp Gly Gln Asn Ile Thr Pro Lys Ile Cys Glu Val Tyr Ser 
            180                 185                 190         


Lys Lys Ser Pro Val Ser Leu Asp Asp Ser Asp Ile Glu Ala Arg Leu 
        195                 200                 205             


Asn Ser Trp Asn Leu Gly Ile Glu Asn Pro Arg Tyr Leu Arg Gln Lys 
    210                 215                 220                 


Pro Ile Pro Val Ser Leu Met Thr Pro Lys Phe Ser Leu Arg Lys Ser 
225                 230                 235                 240 


Ser Ser Phe His Asp Asp His Phe Leu Ser Arg Ile Arg Glu Lys Glu 
                245                 250                 255     


Leu Asp Met Lys Thr Lys Met Met Glu Ala Lys Phe His Glu Glu Lys 
            260                 265                 270         


Leu Lys Leu Gln Gln Lys His Asp Ala Asp Val Gln Lys Ile Leu Glu 
        275                 280                 285             


Arg Lys Asn Asn Glu Ile Glu Glu Leu Lys Thr Leu Tyr Arg Ser Lys 
    290                 295                 300                 


Gln His Glu Thr Glu Glu Thr Ile Arg Lys Leu Glu Lys Lys Val Gln 
305                 310                 315                 320 


Thr Leu Ile Arg Asp Cys Gln Val Ile Arg Glu Thr Lys Glu Asp Gln 
                325                 330                 335     


Ile Ala Glu Leu Lys Lys Ile Cys Glu Gln Ser Thr Glu Ser Leu Asn 
            340                 345                 350         


Asn Asp Trp Glu Lys Lys Leu His Asn Ala Val Ala Glu Met Glu Gln 
        355                 360                 365             


Glu Lys Phe Asp Leu Gln Lys Gln His Thr Glu Asn Ile Gln Glu Leu 
    370                 375                 380                 


Leu Glu Asp Thr Asn Val Arg Leu Asn Lys Met Glu Ser Glu Tyr Met 
385                 390                 395                 400 


Ala Gln Thr Gln Ser Thr Asn His Met Ile Lys Glu Leu Glu Ala Arg 
                405                 410                 415     


Val Gln Gln Leu Thr Gly Glu Ala Glu Asn Ser Asn Leu Gln Arg Gln 
            420                 425                 430         


Lys Leu Ile Gln Glu Lys Ala Glu Leu Glu Arg Cys Tyr Gln Ile Thr 
        435                 440                 445             


Cys Ser Glu Leu Gln Glu Val Lys Ala Arg Arg Asn Thr Leu His Lys 
    450                 455                 460                 


Glu Lys Asp His Leu Val Asn Asp Tyr Glu Gln Asn Met Lys Leu Leu 
465                 470                 475                 480 


Gln Thr Lys Tyr Asp Ala Asp Ile Asn Leu Leu Lys Gln Glu His Ala 
                485                 490                 495     


Leu Ser Ala Ser Lys Ala Ser Ser Met Ile Glu Glu Leu Glu Gln Asn 
            500                 505                 510         


Val Cys Gln Leu Lys Gln Gln Leu Gln Glu Ser Glu Leu Gln Arg Lys 
        515                 520                 525             


Gln Gln Leu Arg Asp Gln Glu Asn Lys Phe Gln Met Glu Lys Ser His 
    530                 535                 540                 


Leu Lys His Ile Tyr Glu Lys Lys Ala His Asp Leu Gln Ser Glu Leu 
545                 550                 555                 560 


Asp Lys Gly Lys Glu Asp Thr Gln Lys Lys Ile His Lys Phe Glu Glu 
                565                 570                 575     


Ala Leu Lys Glu Lys Glu Glu Gln Leu Thr Arg Val Thr Glu Val Gln 
            580                 585                 590         


Arg Leu Gln Ala Gln Gln Ala Asp Ala Ala Leu Glu Glu Phe Lys Arg 
        595                 600                 605             


Gln Val Glu Leu Asn Ser Glu Lys Val Tyr Ala Glu Met Lys Glu Gln 
    610                 615                 620                 


Met Glu Lys Val Glu Ala Asp Leu Thr Arg Ser Lys Ser Leu Arg Glu 
625                 630                 635                 640 


Lys Gln Ser Lys Glu Phe Leu Trp Gln Leu Glu Asp Ile Arg Gln Arg 
                645                 650                 655     


Tyr Glu Gln Gln Ile Val Glu Leu Lys Leu Glu His Glu Gln Glu Lys 
            660                 665                 670         


Thr His Leu Leu Gln Gln His Asn Ala Glu Lys Asp Ser Leu Val Arg 
        675                 680                 685             


Asp His Glu Arg Glu Ile Glu Asn Leu Glu Lys Gln Leu Arg Ala Ala 
    690                 695                 700                 


Asn Met Glu His Glu Asn Gln Ile Gln Glu Phe Lys Lys Arg Asp Ala 
705                 710                 715                 720 


Gln Val Ile Ala Asp Met Glu Ala Gln Val His Lys Leu Arg Glu Glu 
                725                 730                 735     


Leu Ile Asn Val Asn Ser Gln Arg Lys Gln Gln Leu Val Glu Leu Gly 
            740                 745                 750         


Leu Leu Arg Glu Glu Glu Lys Gln Arg Ala Thr Arg Glu His Glu Ile 
        755                 760                 765             


Val Val Asn Lys Leu Lys Ala Glu Ser Glu Lys Met Lys Ile Glu Leu 
    770                 775                 780                 


Lys Lys Thr His Ala Ala Glu Thr Glu Met Thr Leu Glu Lys Ala Asn 
785                 790                 795                 800 


Ser Lys Leu Lys Gln Ile Glu Lys Glu Tyr Thr Gln Lys Leu Ala Lys 
                805                 810                 815     


Ser Ser Gln Ile Ile Ala Glu Leu Gln Thr Thr Ile Ser Ser Leu Lys 
            820                 825                 830         


Glu Glu Asn Ser Gln Gln Gln Leu Ala Ala Glu Arg Arg Leu Gln Asp 
        835                 840                 845             


Val Arg Gln Lys Phe Glu Asp Glu Lys Lys Gln Leu Ile Arg Asp Asn 
    850                 855                 860                 


Asp Gln Ala Ile Lys Val Leu Gln Asp Glu Leu Glu Asn Arg Ser Asn 
865                 870                 875                 880 


Gln Val Arg Cys Ala Glu Lys Lys Leu Gln His Lys Glu Leu Glu Ser 
                885                 890                 895     


Gln Glu Gln Ile Thr Tyr Ile Arg Gln Glu Tyr Glu Thr Lys Leu Lys 
            900                 905                 910         


Gly Leu Met Pro Ala Ser Leu Arg Gln Glu Leu Glu Asp Thr Ile Ser 
        915                 920                 925             


Ser Leu Lys Ser Gln Val Asn Phe Leu Gln Lys Arg Ala Ser Ile Leu 
    930                 935                 940                 


Gln Glu Glu Leu Thr Thr Tyr Gln Gly Arg Arg 
945                 950                 955 


<210> 8684
<211> 277
<212> PRT
<213> Homo sapiens

<400> 8684
Met Leu Ser Gln Lys Glu Val Ala Val Ala Asp Ala Lys Lys Ser Leu 
1               5                   10                  15      


Glu Leu Asn Pro Asn Asn Ser Thr Ala Met Leu Arg Lys Gly Ile Cys 
            20                  25                  30          


Glu Tyr His Glu Lys Asn Tyr Ala Ala Ala Leu Glu Thr Phe Thr Glu 
        35                  40                  45              


Gly Gln Lys Leu Asp Ser Ala Asp Ala Asn Phe Ser Val Trp Ile Lys 
    50                  55                  60                  


Arg Cys Gln Glu Ala Gln Asn Gly Ser Glu Ser Glu Val Trp Thr His 
65                  70                  75                  80  


Gln Ser Lys Ile Lys Tyr Asp Trp Tyr Gln Thr Glu Ser Gln Val Val 
                85                  90                  95      


Ile Thr Leu Met Ile Lys Asn Val Gln Lys Asn Asp Val Asn Val Glu 
            100                 105                 110         


Phe Ser Glu Lys Glu Leu Ser Ala Leu Val Lys Leu Pro Ser Gly Glu 
        115                 120                 125             


Asp Tyr Asn Leu Lys Leu Glu Leu Leu His Pro Ile Ile Pro Glu Gln 
    130                 135                 140                 


Ser Thr Phe Lys Val Leu Ser Thr Lys Ile Glu Ile Lys Leu Lys Lys 
145                 150                 155                 160 


Pro Glu Ala Val Arg Trp Glu Lys Leu Glu Gly Gln Gly Asp Val Pro 
                165                 170                 175     


Thr Pro Lys Gln Phe Val Ala Asp Val Lys Asn Leu Tyr Pro Ser Ser 
            180                 185                 190         


Ser Pro Tyr Thr Arg Asn Trp Asp Lys Leu Val Gly Glu Ile Lys Glu 
        195                 200                 205             


Glu Glu Lys Asn Glu Lys Leu Glu Gly Asp Ala Ala Leu Asn Arg Leu 
    210                 215                 220                 


Phe Gln Gln Ile Tyr Ser Asp Gly Ser Asp Glu Val Lys Arg Ala Met 
225                 230                 235                 240 


Asn Lys Ser Phe Met Glu Ser Gly Gly Thr Val Leu Ser Thr Asn Trp 
                245                 250                 255     


Ser Asp Val Gly Lys Arg Lys Val Glu Ile Asn Pro Pro Asp Asp Met 
            260                 265                 270         


Glu Trp Lys Lys Tyr 
        275         


<210> 8685
<211> 268
<212> PRT
<213> Homo sapiens

<400> 8685
Met Gly Ser Ala Lys Ser Val Pro Val Thr Pro Ala Arg Pro Pro Pro 
1               5                   10                  15      


His Asn Lys His Leu Ala Arg Val Ala Asp Pro Arg Ser Pro Ser Ala 
            20                  25                  30          


Gly Ile Leu Arg Thr Pro Ile Gln Val Glu Ser Ser Pro Gln Pro Gly 
        35                  40                  45              


Leu Pro Ala Gly Glu Gln Leu Glu Gly Leu Lys His Ala Gln Asp Ser 
    50                  55                  60                  


Asp Pro Arg Ser Pro Thr Leu Gly Ile Ala Arg Thr Pro Met Lys Thr 
65                  70                  75                  80  


Ser Ser Gly Asp Pro Pro Ser Pro Leu Val Lys Gln Leu Ser Glu Val 
                85                  90                  95      


Phe Glu Thr Glu Asp Ser Lys Ser Asn Leu Pro Pro Glu Pro Val Leu 
            100                 105                 110         


Pro Pro Glu Ala Pro Leu Ser Ser Glu Leu Asp Leu Pro Leu Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Glu Glu Gln Met Pro Pro Trp Asn Gln Thr Glu Phe 
    130                 135                 140                 


Pro Ser Lys Gln Val Phe Ser Lys Glu Glu Ala Arg Gln Pro Thr Glu 
145                 150                 155                 160 


Thr Pro Val Ala Ser Gln Ser Ser Asp Lys Pro Ser Arg Asp Pro Glu 
                165                 170                 175     


Thr Pro Arg Ser Ser Gly Ser Met Arg Asn Arg Trp Lys Pro Asn Ser 
            180                 185                 190         


Ser Lys Val Leu Gly Arg Ser Pro Leu Thr Ile Leu Gln Asp Asp Asn 
        195                 200                 205             


Ser Pro Gly Thr Leu Thr Leu Arg Gln Gly Lys Arg Pro Ser Pro Leu 
    210                 215                 220                 


Ser Glu Asn Val Ser Glu Leu Lys Glu Gly Ala Ile Leu Gly Thr Gly 
225                 230                 235                 240 


Arg Leu Leu Lys Thr Gly Gly Arg Ala Trp Glu Gln Gly Gln Asp His 
                245                 250                 255     


Asp Lys Glu Asn Gln His Phe Pro Leu Val Glu Ser 
            260                 265             


<210> 8686
<211> 379
<212> PRT
<213> Homo sapiens

<400> 8686
Met Val Phe Lys Leu Lys Thr Lys Glu Glu Gln His Ser Met Leu Gly 
1               5                   10                  15      


Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg Leu Val Ile 
            20                  25                  30          


Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu Ala Gln Lys 
        35                  40                  45              


Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys Asp Glu Arg 
    50                  55                  60                  


Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr Leu Val Glu 
65                  70                  75                  80  


Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu Ala Arg Phe 
                85                  90                  95      


Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu Ala Glu Ser 
            100                 105                 110         


Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser Glu Val Ala 
        115                 120                 125             


Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr Ser Lys Glu 
    130                 135                 140                 


Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val Asn Asp Arg 
145                 150                 155                 160 


Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile Leu Val Glu 
                165                 170                 175     


Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro Tyr Glu Pro 
            180                 185                 190         


Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu Thr Asp Leu 
        195                 200                 205             


Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly Pro Gly Arg 
    210                 215                 220                 


Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro Asp Gly Thr 
225                 230                 235                 240 


Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser Ala Asn Thr 
                245                 250                 255     


Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp Phe Asn Gly Leu 
            260                 265                 270         


Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His Pro Pro Gln Ile 
        275                 280                 285             


Pro Ala Thr Pro Pro Ser Tyr Glu Ser Val Asp Asp Ile Asn Ala Asp 
    290                 295                 300                 


Lys Asn Ile Ser Ser Ala Gln Ile Val Gly Pro Gly Pro Lys Pro Glu 
305                 310                 315                 320 


Ala Ser Ala Lys Leu Pro Ser Arg Pro Ala Asp Asn Tyr Asp Asn Phe 
                325                 330                 335     


Val Leu Pro Glu Leu Pro Ser Val Pro Asp Thr Leu Pro Thr Ala Ser 
            340                 345                 350         


Ala Gly Ala Ser Thr Ser Ala Ser Glu Asp Ile Asp Phe Asp Asp Leu 
        355                 360                 365             


Ser Arg Arg Phe Glu Glu Leu Lys Lys Lys Thr 
    370                 375                 


<210> 8687
<211> 300
<212> PRT
<213> Homo sapiens

<400> 8687
Met Ala Arg Pro Leu Ser Thr Pro Ser Ser Ser Gln Met Gln Ala Arg 
1               5                   10                  15      


Lys Lys His Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn 
            20                  25                  30          


Ser Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Thr Ala Phe Glu Lys 
        35                  40                  45              


Gln Gly Ser Ser Lys Leu Glu Lys Ala Glu Val Leu Gln Met Thr Val 
    50                  55                  60                  


Asp His Leu Lys Met Leu His Ala Thr Gly Gly Thr Gly Phe Phe Asp 
65                  70                  75                  80  


Ala Arg Ala Leu Ala Val Asp Phe Arg Ser Ile Gly Phe Arg Glu Cys 
                85                  90                  95      


Leu Thr Glu Val Ile Arg Tyr Leu Gly Val Leu Glu Gly Pro Ser Ser 
            100                 105                 110         


Arg Ala Asp Pro Val Arg Ile Arg Leu Leu Ser His Leu Asn Ser Tyr 
        115                 120                 125             


Ala Ala Glu Met Glu Pro Ser Pro Thr Pro Thr Gly Pro Leu Ala Phe 
    130                 135                 140                 


Pro Ala Trp Pro Trp Ser Phe Phe His Ser Cys Pro Gly Leu Pro Ala 
145                 150                 155                 160 


Leu Ser Asn Gln Leu Ala Ile Leu Gly Arg Val Pro Ser Pro Val Leu 
                165                 170                 175     


Pro Gly Val Ser Ser Pro Ala Tyr Pro Ile Pro Ala Leu Arg Thr Ala 
            180                 185                 190         


Pro Leu Arg Arg Ala Thr Gly Ile Ile Leu Pro Ala Arg Arg Asn Val 
        195                 200                 205             


Leu Pro Ser Arg Gly Ala Ser Ser Thr Arg Arg Ala Arg Pro Leu Glu 
    210                 215                 220                 


Arg Pro Ala Thr Pro Val Pro Val Ala Pro Ser Ser Arg Ala Ala Arg 
225                 230                 235                 240 


Ser Ser His Ile Ala Pro Leu Leu Gln Ser Ser Ser Pro Thr Pro Pro 
                245                 250                 255     


Gly Pro Thr Gly Ser Ala Ala Tyr Val Ala Val Pro Thr Pro Asn Ser 
            260                 265                 270         


Ser Ser Pro Gly Pro Ala Gly Arg Pro Ala Gly Ala Met Leu Tyr His 
        275                 280                 285             


Ser Trp Val Ser Glu Ile Thr Glu Ile Gly Ala Phe 
    290                 295                 300 


<210> 8688
<211> 105
<212> PRT
<213> Homo sapiens

<400> 8688
Met Ser Val Val Pro Pro Asn Arg Ser Gln Thr Gly Trp Pro Arg Gly 
1               5                   10                  15      


Val Thr Gln Phe Gly Asn Lys Tyr Ile Gln Gln Thr Lys Pro Leu Thr 
            20                  25                  30          


Leu Glu Arg Thr Ile Asn Leu Tyr Pro Leu Thr Asn Tyr Thr Phe Gly 
        35                  40                  45              


Thr Lys Glu Pro Leu Tyr Glu Lys Asp Ser Ser Val Ala Ala Arg Phe 
    50                  55                  60                  


Gln Arg Met Arg Glu Glu Phe Asp Lys Ile Gly Met Arg Arg Thr Val 
65                  70                  75                  80  


Glu Gly Val Leu Ile Val His Glu His Arg Leu Pro His Val Leu Leu 
                85                  90                  95      


Leu Ser Arg Phe Asn Phe Ile Tyr Asn 
            100                 105 


<210> 8689
<211> 195
<212> PRT
<213> Homo sapiens

<400> 8689
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys 
    50                  55                  60                  


Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Pro Thr Cys Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr 
                85                  90                  95      


Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr 
            100                 105                 110         


Glu Asn Gly Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile 
        115                 120                 125             


Thr Ser Arg Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn 
    130                 135                 140                 


Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg 
145                 150                 155                 160 


Val Leu Ile Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu 
                165                 170                 175     


Phe His Asn Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser 
            180                 185                 190         


Glu Pro Val 
        195 


<210> 8690
<211> 526
<212> PRT
<213> Homo sapiens

<400> 8690
Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Asp Val Phe 
1               5                   10                  15      


Trp Arg Cys Arg Gln Asn Ile Phe Asp Glu Met Lys Lys Lys Phe Leu 
            20                  25                  30          


Gln Ile Glu Asn Ala Ala Glu Glu Pro Arg Val Leu Cys Ile Ile Gln 
        35                  40                  45              


Asp Thr Thr Asn Ser Lys Thr Val Asn Glu Arg Ile Thr Leu Asn Leu 
    50                  55                  60                  


Pro Ala Ser Thr Pro Val Arg Lys Leu Phe Glu Asp Val Ala Asn Lys 
65                  70                  75                  80  


Val Gly Tyr Ile Asn Gly Thr Phe Asp Leu Val Trp Gly Asn Gly Ile 
                85                  90                  95      


Asn Thr Ala Asp Met Ala Pro Leu Asp His Thr Ser Asp Lys Ser Leu 
            100                 105                 110         


Leu Asp Ala Asn Phe Glu Pro Gly Lys Lys Asn Phe Leu His Leu Thr 
        115                 120                 125             


Asp Lys Asp Gly Glu Gln Pro Gln Ile Leu Leu Glu Asp Ser Ser Ala 
    130                 135                 140                 


Gly Glu Asp Ser Val His Asp Arg Phe Ile Gly Pro Leu Pro Arg Glu 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Thr Ser Asp Tyr Val Ser Gln Ser Tyr Ser Tyr 
                165                 170                 175     


Ser Ser Ile Leu Asn Lys Ser Glu Thr Gly Tyr Val Gly Leu Val Asn 
            180                 185                 190         


Gln Ala Met Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu Phe Met 
        195                 200                 205             


Thr Pro Glu Phe Arg Asn Ala Leu Tyr Lys Trp Glu Phe Glu Glu Ser 
    210                 215                 220                 


Glu Glu Asp Pro Val Thr Ser Ile Pro Tyr Gln Leu Gln Arg Leu Phe 
225                 230                 235                 240 


Val Leu Leu Gln Thr Ser Lys Lys Arg Ala Ile Glu Thr Thr Asp Val 
                245                 250                 255     


Thr Arg Ser Phe Gly Trp Asp Ser Ser Glu Ala Trp Gln Gln His Asp 
            260                 265                 270         


Val Gln Glu Leu Cys Arg Val Met Phe Asp Ala Leu Glu Gln Lys Trp 
        275                 280                 285             


Lys Gln Thr Glu Gln Ala Asp Leu Ile Asn Glu Leu Tyr Gln Gly Lys 
    290                 295                 300                 


Leu Lys Asp Tyr Val Arg Cys Leu Glu Cys Gly Tyr Glu Gly Trp Arg 
305                 310                 315                 320 


Ile Asp Thr Tyr Leu Asp Ile Pro Leu Val Ile Arg Pro Tyr Gly Ser 
                325                 330                 335     


Ser Gln Ala Phe Ala Ser Val Glu Glu Ala Leu His Ala Phe Ile Gln 
            340                 345                 350         


Pro Glu Ile Leu Asp Gly Pro Asn Gln Tyr Phe Cys Glu Arg Cys Lys 
        355                 360                 365             


Lys Lys Cys Asp Ala Arg Lys Gly Leu Arg Phe Leu His Phe Pro Tyr 
    370                 375                 380                 


Leu Leu Thr Leu Gln Leu Lys Arg Phe Asp Phe Asp Tyr Thr Thr Met 
385                 390                 395                 400 


His Arg Ile Lys Leu Asn Asp Arg Met Thr Phe Pro Glu Glu Leu Asp 
                405                 410                 415     


Met Ser Thr Phe Ile Asp Val Glu Asp Glu Lys Ser Pro Gln Thr Glu 
            420                 425                 430         


Ser Cys Thr Asp Ser Gly Ala Glu Asn Glu Gly Ser Cys His Ser Asp 
        435                 440                 445             


Gln Met Ser Asn Asp Phe Ser Asn Asp Asp Gly Val Asp Glu Gly Ile 
    450                 455                 460                 


Cys Leu Glu Thr Asn Ser Gly Thr Glu Lys Ile Ser Lys Ser Gly Leu 
465                 470                 475                 480 


Glu Lys Asn Ser Leu Ile Tyr Glu Leu Phe Ser Val Met Val His Ser 
                485                 490                 495     


Gly Ser Ala Ala Gly Gly His Tyr Tyr Ala Cys Ile Lys Ser Ser Val 
            500                 505                 510         


Met Ser Ser Gly Thr Ala Ser Met Ile Asn Met Ser Ala Gly 
        515                 520                 525     


<210> 8691
<211> 320
<212> PRT
<213> Homo sapiens

<400> 8691
Met Gly Lys Glu Gln Glu Leu Leu Glu Ala Ala Arg Thr Gly His Leu 
1               5                   10                  15      


Pro Ala Val Glu Lys Leu Leu Ser Gly Lys Arg Leu Ser Ser Gly Phe 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Leu Gly Ser Ser Ser His Pro Leu Ser Ser Leu 
    50                  55                  60                  


Leu Ser Met Trp Arg Gly Pro Asn Val Asn Cys Val Asp Ser Thr Gly 
65                  70                  75                  80  


Tyr Thr Pro Leu His His Ala Ala Leu Asn Gly His Lys Asp Val Val 
                85                  90                  95      


Glu Val Leu Leu Arg Asn Asp Ala Leu Thr Asn Val Ala Asp Ser Lys 
            100                 105                 110         


Gly Cys Tyr Pro Leu His Leu Ala Ala Trp Lys Gly Asp Ala Gln Ile 
        115                 120                 125             


Val Arg Leu Leu Ile His Gln Gly Pro Ser His Thr Arg Val Asn Glu 
    130                 135                 140                 


Gln Asn Asn Asp Asn Glu Thr Ala Leu His Cys Ala Ala Gln Tyr Gly 
145                 150                 155                 160 


His Thr Glu Val Val Lys Val Leu Leu Glu Glu Leu Thr Asp Pro Thr 
                165                 170                 175     


Met Arg Asn Asn Lys Phe Glu Thr Pro Leu Asp Leu Ala Ala Leu Tyr 
            180                 185                 190         


Gly Arg Leu Glu Val Val Lys Met Leu Leu Asn Ala His Pro Asn Leu 
        195                 200                 205             


Leu Ser Cys Asn Thr Lys Lys His Thr Pro Leu His Leu Ala Ala Arg 
    210                 215                 220                 


Asn Gly His Lys Ala Val Val Gln Val Leu Leu Asp Ala Gly Met Asp 
225                 230                 235                 240 


Ser Asn Tyr Gln Thr Glu Met Gly Ser Ala Leu His Glu Ala Ala Leu 
                245                 250                 255     


Phe Gly Lys Thr Asp Val Val Gln Ile Leu Leu Ala Ala Gly Thr Asp 
            260                 265                 270         


Val Asn Ile Lys Asp Asn His Gly Leu Thr Ala Leu Asp Thr Val Arg 
        275                 280                 285             


Glu Leu Pro Ser Gln Lys Ser Gln Gln Ile Ala Ala Leu Ile Glu Asp 
    290                 295                 300                 


Leu Asp Thr Leu Gln Phe Tyr Phe Ile Ser Cys Pro Phe Gln Gly Leu 
305                 310                 315                 320 


<210> 8692
<211> 219
<212> PRT
<213> Homo sapiens

<400> 8692
Met Val Ile His Lys Asn Pro Pro Asp Thr Pro Thr Glu Ser Gln Phe 
1               5                   10                  15      


Thr Arg Phe Leu Cys Ser Ser Pro Leu Glu Ala Glu Thr Pro Pro Asn 
            20                  25                  30          


Gly Pro Asp Cys Gly Tyr Gly Ser Phe His Gln Gln Tyr Trp Leu Asp 
        35                  40                  45              


Gly Lys Ile Ile Ala Val Gly Val Ile Asp Ile Leu Pro Asn Cys Val 
    50                  55                  60                  


Ser Ser Val Tyr Leu Tyr Tyr Asp Pro Asp Tyr Ser Phe Leu Ser Leu 
65                  70                  75                  80  


Gly Val Tyr Ser Ala Leu Arg Glu Ile Ala Phe Thr Arg Gln Leu His 
                85                  90                  95      


Glu Lys Thr Ser Gln Leu Ser Tyr Tyr Tyr Met Gly Phe Tyr Ile His 
            100                 105                 110         


Ser Cys Pro Lys Met Lys Tyr Lys Gly Gln Tyr Arg Pro Ser Asp Leu 
        115                 120                 125             


Leu Cys Pro Glu Thr Tyr Val Trp Val Pro Ile Glu Gln Cys Leu Pro 
    130                 135                 140                 


Ser Leu Glu Asn Ser Lys Tyr Cys Arg Phe Asn Gln Asp Pro Glu Ala 
145                 150                 155                 160 


Val Asp Glu Asp Arg Ser Thr Glu Pro Asp Arg Leu Gln Val Phe His 
                165                 170                 175     


Lys Arg Ala Ile Met Pro Tyr Gly Val Tyr Lys Lys Gln Gln Lys Asp 
            180                 185                 190         


Pro Ser Glu Glu Ala Ala Val Leu Gln Tyr Ala Ser Leu Val Gly Gln 
        195                 200                 205             


Lys Cys Ser Glu Arg Met Leu Leu Phe Arg Asn 
    210                 215                 


<210> 8693
<211> 596
<212> PRT
<213> Homo sapiens

<400> 8693
Met Gln Gln Lys Glu Leu Gly Thr Phe Ala Gln Ser Ser Ile Ala Leu 
1               5                   10                  15      


His His Gln Tyr Asn Pro Lys Phe Gln Thr Leu Phe Gln Pro Cys Asn 
            20                  25                  30          


Leu Met Gly Ala Met Gln Leu Ile Glu Asp Phe Ser Thr His Val Ser 
        35                  40                  45              


Ile Asp Cys Ser Pro His Lys Thr Val Lys Lys Thr Ala Asn Glu Phe 
    50                  55                  60                  


Pro Cys Leu Pro Lys Gln Val Ala Trp Ile Leu Ala Thr Ser Lys Val 
65                  70                  75                  80  


Phe Met Tyr Pro Glu Leu Leu Pro Val Cys Ser Leu Lys Ala Lys Asn 
                85                  90                  95      


Pro Gln Asp Lys Ile Leu Phe Thr Lys Ala Glu Asp Asn Lys Tyr Leu 
            100                 105                 110         


Leu Thr Cys Lys Thr Ala Arg Gln Leu Thr Val Arg Ile Lys Asn Leu 
        115                 120                 125             


Asn Met Asn Arg Ala Pro Asp Asn Ile Ile Lys Phe Tyr Lys Lys Thr 
    130                 135                 140                 


Lys Gln Leu Pro Val Leu Gly Lys Cys Cys Glu Glu Ile Gln Pro His 
145                 150                 155                 160 


Gln Trp Lys Pro Pro Ile Glu Arg Glu Glu His Arg Leu Pro Phe Trp 
                165                 170                 175     


Leu Lys Ala Ser Leu Pro Ser Ile Gln Glu Glu Leu Arg His Met Ala 
            180                 185                 190         


Asp Gly Ala Arg Glu Val Gly Asn Met Thr Gly Thr Thr Glu Ile Asn 
        195                 200                 205             


Ser Asp Gln Gly Leu Glu Lys Asp Asn Ser Glu Leu Gly Ser Glu Thr 
    210                 215                 220                 


Arg Tyr Pro Leu Leu Leu Pro Lys Gly Val Val Leu Lys Leu Lys Pro 
225                 230                 235                 240 


Val Ala Asp Arg Phe Pro Lys Lys Ala Trp Arg Gln Lys Arg Ser Ser 
                245                 250                 255     


Val Leu Lys Pro Leu Leu Ile Gln Pro Ser Pro Ser Leu Gln Pro Ser 
            260                 265                 270         


Phe Asn Pro Gly Lys Thr Pro Ala Gln Ser Thr His Ser Glu Ala Pro 
        275                 280                 285             


Pro Ser Lys Met Val Leu Arg Ile Pro His Pro Ile Gln Pro Ala Thr 
    290                 295                 300                 


Val Leu Gln Thr Val Pro Gly Val Pro Pro Leu Gly Val Ser Gly Gly 
305                 310                 315                 320 


Glu Ser Phe Glu Ser Pro Ala Ala Leu Pro Ala Met Pro Pro Glu Ala 
                325                 330                 335     


Arg Thr Ser Phe Pro Leu Ser Glu Ser Gln Thr Leu Leu Ser Ser Ala 
            340                 345                 350         


Pro Val Pro Lys Val Met Met Pro Ser Pro Ala Ser Ser Met Phe Arg 
        355                 360                 365             


Lys Pro Tyr Val Arg Arg Arg Pro Ser Lys Arg Arg Gly Ala Arg Ala 
    370                 375                 380                 


Phe Arg Cys Ile Lys Pro Ala Pro Val Ile His Pro Ala Ser Val Ile 
385                 390                 395                 400 


Phe Thr Val Pro Ala Thr Thr Val Lys Ile Val Ser Leu Gly Gly Gly 
                405                 410                 415     


Cys Asn Met Ile Gln Pro Val Asn Ala Ala Val Ala Gln Ser Pro Gln 
            420                 425                 430         


Thr Ile Pro Ile Ala Thr Leu Leu Val Asn Pro Thr Ser Phe Pro Cys 
        435                 440                 445             


Pro Leu Asn Gln Pro Leu Val Ala Ser Ser Val Ser Pro Leu Ile Val 
    450                 455                 460                 


Ser Gly Asn Ser Val Asn Leu Pro Ile Pro Ser Thr Pro Glu Asp Lys 
465                 470                 475                 480 


Ala His Met Asn Val Asp Ile Ala Cys Ala Val Ala Asp Gly Glu Asn 
                485                 490                 495     


Ala Phe Gln Gly Leu Glu Pro Lys Leu Glu Pro Gln Glu Leu Ser Pro 
            500                 505                 510         


Leu Ser Ala Thr Val Phe Pro Lys Val Glu His Ser Pro Gly Pro Pro 
        515                 520                 525             


Pro Val Asp Lys Gln Cys Gln Glu Gly Leu Ser Glu Asn Ser Ala Tyr 
    530                 535                 540                 


Arg Trp Thr Val Val Lys Thr Glu Glu Gly Arg Gln Ala Leu Glu Pro 
545                 550                 555                 560 


Leu Pro Gln Gly Ile Gln Glu Ser Leu Asn Asn Ser Ser Pro Gly Asp 
                565                 570                 575     


Leu Glu Glu Val Val Lys Met Glu Pro Glu Asp Ala Thr Glu Glu Ile 
            580                 585                 590         


Ser Gly Phe Leu 
        595     


<210> 8694
<211> 303
<212> PRT
<213> Homo sapiens

<400> 8694
Met Ala Asp Lys Ser Lys Phe Ile Glu Tyr Ile Asp Glu Ala Leu Glu 
1               5                   10                  15      


Lys Ser Lys Glu Thr Ala Leu Ser His Leu Phe Phe Thr Tyr Gln Gly 
            20                  25                  30          


Ile Pro Tyr Pro Ile Thr Met Cys Thr Ser Glu Thr Phe Gln Ala Leu 
        35                  40                  45              


Asp Thr Phe Glu Ala Arg His Asp Asp Ile Val Leu Ala Ser Tyr Pro 
    50                  55                  60                  


Lys Cys Gly Ser Asn Trp Ile Leu His Ile Val Ser Glu Leu Ile Tyr 
65                  70                  75                  80  


Ala Val Ser Lys Lys Lys Tyr Lys Tyr Pro Glu Phe Pro Val Leu Glu 
                85                  90                  95      


Cys Gly Asp Ser Glu Lys Tyr Gln Arg Met Lys Gly Phe Pro Ser Pro 
            100                 105                 110         


Arg Ile Leu Ala Thr His Leu His Tyr Asp Lys Leu Pro Gly Ser Ile 
        115                 120                 125             


Phe Glu Asn Lys Ala Lys Ile Leu Val Ile Phe Arg Asn Pro Lys Asp 
    130                 135                 140                 


Thr Ala Val Ser Phe Leu His Phe His Asn Asp Val Pro Asp Ile Pro 
145                 150                 155                 160 


Ser Tyr Gly Ser Trp Asp Glu Phe Phe Arg Gln Phe Met Lys Gly Gln 
                165                 170                 175     


Val Ser Trp Gly Arg Tyr Phe Asp Phe Ala Ile Asn Trp Asn Lys His 
            180                 185                 190         


Leu Asp Gly Asp Asn Val Lys Phe Ile Leu Tyr Glu Asp Leu Lys Glu 
        195                 200                 205             


Asn Leu Ala Ala Gly Ile Lys Gln Ile Ala Glu Phe Leu Gly Phe Phe 
    210                 215                 220                 


Leu Thr Gly Glu Gln Ile Gln Thr Ile Ser Val Gln Ser Thr Phe Gln 
225                 230                 235                 240 


Ala Met Arg Ala Lys Ser Gln Asp Thr His Gly Ala Val Gly Pro Phe 
                245                 250                 255     


Leu Phe Arg Lys Gly Glu Val Gly Asp Trp Lys Asn Leu Phe Ser Glu 
            260                 265                 270         


Ile Gln Asn Gln Glu Met Asp Glu Lys Phe Lys Glu Cys Leu Ala Gly 
        275                 280                 285             


Thr Ser Leu Gly Ala Lys Leu Lys Tyr Glu Ser Tyr Cys Gln Gly 
    290                 295                 300             


<210> 8695
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8695
Met Gly Val Pro Glu Ile Pro Gly Glu Lys Leu Val Thr Glu Arg Asn 
1               5                   10                  15      


Lys Lys Arg Leu Glu Lys Glu Lys His Glu Lys Gly Ala Gln Lys Thr 
            20                  25                  30          


Asp Cys Gln Lys Asn Leu Gly Thr Val Gly Ala Val Ala Leu Asp Cys 
        35                  40                  45              


Lys Gly Asn Val Ala Tyr Ala Thr Ser Thr Gly Gly Ile Val Asn Lys 
    50                  55                  60                  


Met Val Gly Arg Val Gly Asp Ser Pro Cys Leu Gly Arg Thr Lys Gly 
65                  70                  75                  80  


Cys Leu Leu Pro Leu Pro Leu Phe Ser Arg Pro Gln Ala Phe Leu Thr 
                85                  90                  95      


Leu Tyr Ser Leu Pro Leu Ser Val Ser Cys Cys Val Pro Phe Leu Leu 
            100                 105                 110         


Leu Val Gln Leu Gln Asp Val Trp Glu 
        115                 120     


<210> 8696
<211> 192
<212> PRT
<213> Homo sapiens

<400> 8696
Met Thr Leu Gly Ser Lys Ser Gln Gln Pro Pro Glu Asp Ile Lys Ala 
1               5                   10                  15      


Leu Ser Trp Asn Arg Gln Ala Gln His Ile Leu Ser Ser Ala His Pro 
            20                  25                  30          


Ser Gly Lys Ala Val Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile 
        35                  40                  45              


Lys Val Ser Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp 
    50                  55                  60                  


His Pro Asp Ile Ala Thr Gln Leu Val Leu Cys Ser Glu Asp Asp Arg 
65                  70                  75                  80  


Leu Pro Val Ile Gln Leu Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu 
                85                  90                  95      


Lys Val Leu Glu Ser His Ser Arg Gly Ile Leu Ser Val Ser Trp Ser 
            100                 105                 110         


Gln Ala Asp Ala Glu Leu Leu Leu Thr Ser Ala Lys Asp Ser Gln Ile 
        115                 120                 125             


Leu Cys Arg Asn Leu Gly Ser Ser Glu Val Val Tyr Lys Leu Pro Thr 
    130                 135                 140                 


Gln Ser Ser Trp Cys Phe Asp Val Gln Trp Cys Pro Arg Asp Pro Ser 
145                 150                 155                 160 


Val Phe Ser Ala Ala Ser Phe Asn Gly Trp Ile Ser Leu Tyr Ser Val 
                165                 170                 175     


Met Gly Arg Ser Trp Glu Val Gln His Met Arg Gln Ala Asp Lys Val 
            180                 185                 190         


<210> 8697
<211> 206
<212> PRT
<213> Homo sapiens

<400> 8697
Met Lys Asp Val Asp Asn Leu Lys Ser Ile Lys Glu Glu Trp Val Cys 
1               5                   10                  15      


Glu Thr Gly Ser Asp Asn Gln Pro Leu Gly Asn Asn Gln Gln Ser Asn 
            20                  25                  30          


Cys Glu Tyr Phe Val Asp Ser Leu Phe Glu Glu Ala Gln Lys Val Ser 
        35                  40                  45              


Ser Lys Cys Val Ser Pro Ala Glu Gln Lys Lys Gln Val Asp Val Asn 
    50                  55                  60                  


Ile Lys Leu Trp Lys Asn Gly Phe Thr Val Asn Asp Asp Phe Arg Ser 
65                  70                  75                  80  


Tyr Ser Asp Gly Ala Ser Gln Gln Phe Leu Asn Ser Ile Lys Lys Gly 
                85                  90                  95      


Glu Leu Pro Ser Glu Leu Gln Gly Ile Phe Asp Lys Glu Glu Val Asp 
            100                 105                 110         


Val Lys Val Glu Asp Lys Lys Asn Glu Ile Cys Leu Ser Thr Lys Pro 
        115                 120                 125             


Val Phe Gln Pro Phe Ser Gly Gln Gly His Arg Leu Gly Arg Val Ser 
    130                 135                 140                 


His Ile Lys Asp Phe Ile Glu Lys Tyr Gln Gly Ser Gln Arg Ser Pro 
145                 150                 155                 160 


Pro Phe Ser Leu Ala Thr Ala Leu Pro Val Leu Arg Leu Leu Asp Glu 
                165                 170                 175     


Thr Leu Thr Leu Glu Glu Ala Asp Leu Gln Asn Ala Val Ile Ile Gln 
            180                 185                 190         


Arg Leu Gln Lys Thr Ala Ser Phe Arg Glu Leu Ser Glu His 
        195                 200                 205     


<210> 8698
<211> 452
<212> PRT
<213> Homo sapiens

<400> 8698
Met Arg Gly Cys Ser Tyr Gly Leu Cys Arg Arg Gly Leu Leu Phe Cys 
1               5                   10                  15      


Val Ile Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn Asp Lys Asn 
            20                  25                  30          


Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu Glu Glu Lys 
        35                  40                  45              


Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro Ser Gly Thr 
    50                  55                  60                  


Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys Lys Gln Ala 
65                  70                  75                  80  


Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val Leu His Leu 
                85                  90                  95      


Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu Tyr Glu Ala 
            100                 105                 110         


Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn His Ile Ser 
        115                 120                 125             


Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln Lys Asp Leu 
    130                 135                 140                 


Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn Gln Lys Ser 
145                 150                 155                 160 


Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn Asp Leu Glu 
                165                 170                 175     


Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala Tyr Leu Thr 
            180                 185                 190         


Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe Lys Asn Leu 
        195                 200                 205             


Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile Glu Ile Leu 
    210                 215                 220                 


Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val Val Asn Glu 
225                 230                 235                 240 


Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu Val Phe Asn 
                245                 250                 255     


Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe Thr Arg Asn 
            260                 265                 270         


Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val Cys Thr Arg 
        275                 280                 285             


Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu Arg Lys His 
    290                 295                 300                 


Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu Ala Pro Pro 
305                 310                 315                 320 


Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly Phe Asn Leu 
                325                 330                 335     


Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu Asp Leu Ala 
            340                 345                 350         


Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu Asn Thr Arg 
        355                 360                 365             


Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly Thr Met Arg 
    370                 375                 380                 


Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala Asn Ser His 
385                 390                 395                 400 


Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp Phe Glu Met 
                405                 410                 415     


Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His Val Gln Ala 
            420                 425                 430         


Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu Leu Phe Tyr 
        435                 440                 445             


Glu Arg Ile Leu 
    450         


<210> 8699
<211> 149
<212> PRT
<213> Homo sapiens

<400> 8699
Met Glu Arg Ile Glu Gly Ala Ser Val Gly Arg Cys Ala Ala Ser Pro 
1               5                   10                  15      


Tyr Leu Arg Pro Leu Thr Leu His Tyr Arg Gln Asn Gly Ala Gln Lys 
            20                  25                  30          


Ser Trp Asp Phe Met Lys Thr His Asp Ser Val Thr Val Leu Leu Phe 
        35                  40                  45              


Asn Ser Ser Arg Arg Ser Leu Val Leu Val Lys Gln Phe Arg Pro Ala 
    50                  55                  60                  


Val Tyr Ala Gly Glu Val Glu Arg Arg Phe Pro Gly Ser Leu Ala Ala 
65                  70                  75                  80  


Val Asp Gln Asp Gly Pro Arg Glu Leu Gln Pro Ala Leu Pro Gly Ser 
                85                  90                  95      


Ala Gly Val Thr Val Glu Leu Cys Ala Gly Leu Val Asp Gln Pro Gly 
            100                 105                 110         


Leu Ser Leu Glu Glu Val Ala Cys Lys Glu Ala Trp Glu Glu Cys Gly 
        115                 120                 125             


Tyr His Leu Ala Pro Ser Asp Leu Arg Arg Val Ala Thr Tyr Trp Asp 
    130                 135                 140                 


Ala Thr Met Gly Ser 
145                 


<210> 8700
<211> 162
<212> PRT
<213> Homo sapiens

<400> 8700
Met Asn Ser Asn Ala Ser Glu His Thr Gly Met Leu Arg Thr Cys Trp 
1               5                   10                  15      


Ser His Ser His Trp Asp Pro Phe Ser Ser Gly Ser Val Thr Ala Met 
            20                  25                  30          


Trp Ala Thr His Ser Pro Thr Ser Lys Ala Trp Ala Gly Ile Gln Gly 
        35                  40                  45              


Arg Gly Arg Trp Ala Leu Gly Phe Pro Trp Arg Gly Gln Gly Val Leu 
    50                  55                  60                  


His Val Ile Ala Ser Gln Lys Ala Ala Val Thr Glu Ala Val Asp Leu 
65                  70                  75                  80  


Arg Thr Gly Ala Ala Ser Gln Ala Met Ser Glu Ala Phe Val Arg Ser 
                85                  90                  95      


Gly Met Phe Tyr Leu Arg Pro Ala Phe Val Leu Leu Cys Tyr Lys Trp 
            100                 105                 110         


Gly Lys Leu Arg His Ser Glu Val Ser Asn Leu Leu Gly Val Ala Trp 
        115                 120                 125             


Pro Val Ser Glu Glu Ala Cys Met Gly Thr Trp Gly Ser Leu Ala Val 
    130                 135                 140                 


Ala Val Thr Leu Pro Ala Gln Gly Leu Gly Thr Trp Gly Arg Asp Glu 
145                 150                 155                 160 


Gly Glu 
        


<210> 8701
<211> 439
<212> PRT
<213> Homo sapiens

<400> 8701
Met Val Pro Ser Arg Glu Ala Leu Leu Gly Pro Gly Thr Thr Ala Ile 
1               5                   10                  15      


Arg Cys Pro Lys Lys Leu Gln Asn Gln Asn Tyr Lys Gly His Gly Leu 
            20                  25                  30          


Ser Lys Gly Lys Glu Arg Glu Gln Arg Ala Ser Ile Arg Phe Lys Thr 
        35                  40                  45              


Thr Leu Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp 
    50                  55                  60                  


Val Glu Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Cys Asp Val 
65                  70                  75                  80  


Ser Trp Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val 
                85                  90                  95      


Arg Ile Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr 
            100                 105                 110         


Met Val Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala 
        115                 120                 125             


Gly Lys Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu 
    130                 135                 140                 


Met Pro Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro 
145                 150                 155                 160 


Gly Ile Thr Trp Ile Met Lys Pro Val Ala Arg Ser Gln Gly Lys Gly 
                165                 170                 175     


Ile Phe Leu Phe Arg Arg Leu Lys Asp Ile Val Asp Trp Arg Lys Asp 
            180                 185                 190         


Thr Arg Ser Ser Asp Asp Gln Lys Asp Asp Ile Pro Val Glu Asn Tyr 
        195                 200                 205             


Val Ala Gln Arg Tyr Ile Glu Asn Pro Tyr Leu Ile Gly Gly Arg Lys 
    210                 215                 220                 


Phe Asp Leu Arg Val Tyr Val Leu Val Met Ser Val Phe Ala Glu Cys 
225                 230                 235                 240 


Leu Leu Trp Ser Gly His Arg Arg Gln Asp Val His Leu Thr Asn Val 
                245                 250                 255     


Ala Val Gln Lys Thr Ser Pro Asp Tyr His Pro Lys Lys Gly Cys Lys 
            260                 265                 270         


Trp Thr Leu Gln Arg Phe Arg Gln Tyr Leu Ala Ser Lys His Gly Pro 
        275                 280                 285             


Glu Ala Val Glu Thr Leu Phe Arg Asp Ile Asp Asn Ile Phe Val Lys 
    290                 295                 300                 


Ser Leu Gln Ser Val Gln Lys Val Ile Ile Ser Asp Lys His Cys Phe 
305                 310                 315                 320 


Glu Leu Tyr Gly Tyr Asp Ile Leu Ile Asp Gln Asp Leu Lys Pro Trp 
                325                 330                 335     


Leu Leu Glu Val Asn Ala Ser Pro Ser Leu Thr Ala Ser Ser Gln Glu 
            340                 345                 350         


Asp Tyr Glu Leu Lys Thr Cys Leu Leu Glu Asp Thr Leu His Val Val 
        355                 360                 365             


Asp Met Glu Ala Arg Leu Thr Gly Arg Glu Lys Arg Val Gly Gly Phe 
    370                 375                 380                 


Asp Leu Met Trp Asn Asp Gly Pro Val Ser Arg Glu Glu Gly Ala Pro 
385                 390                 395                 400 


Asp Leu Ser Gly Met Gly Asn Phe Val Thr Asn Thr His Leu Gly Cys 
                405                 410                 415     


Val Asn Asp Arg Lys Lys Gln Leu Arg Gln Leu Phe Cys Ser Leu Gln 
            420                 425                 430         


Val Gln Lys Lys Ala Ser Ser 
        435                 


<210> 8702
<211> 288
<212> PRT
<213> Homo sapiens

<400> 8702
Met Ala Lys Trp Gly Glu Gly Asp Pro Arg Trp Ile Val Glu Glu Arg 
1               5                   10                  15      


Ala Asp Ala Thr Asn Val Asn Asn Trp His Trp Thr Glu Arg Asp Ala 
            20                  25                  30          


Ser Asn Trp Ser Thr Asp Lys Leu Lys Thr Leu Phe Leu Ala Val Gln 
        35                  40                  45              


Val Gln Asn Glu Glu Gly Lys Cys Glu Val Thr Glu Val Ser Lys Leu 
    50                  55                  60                  


Asp Gly Glu Ala Ser Ile Asn Asn Arg Lys Gly Lys Leu Ile Phe Phe 
65                  70                  75                  80  


Tyr Glu Trp Ser Val Lys Leu Asn Trp Thr Gly Thr Ser Lys Ser Gly 
                85                  90                  95      


Val Gln Tyr Lys Gly His Val Glu Ile Pro Asn Leu Ser Asp Glu Asn 
            100                 105                 110         


Ser Val Asp Glu Val Glu Ile Ser Val Ser Leu Ala Lys Asp Glu Pro 
        115                 120                 125             


Asp Thr Asn Leu Val Ala Leu Met Lys Glu Glu Gly Val Lys Leu Leu 
    130                 135                 140                 


Arg Glu Ala Met Gly Ile Tyr Ile Ser Thr Leu Lys Thr Glu Phe Thr 
145                 150                 155                 160 


Gln Gly Met Ile Leu Pro Thr Met Asn Gly Glu Ser Val Asp Pro Val 
                165                 170                 175     


Gly Gln Pro Ala Leu Lys Thr Glu Glu Arg Lys Ala Lys Pro Ala Pro 
            180                 185                 190         


Ser Lys Thr Gln Ala Arg Pro Val Gly Val Lys Ile Pro Thr Cys Lys 
        195                 200                 205             


Ile Thr Leu Lys Glu Thr Phe Leu Thr Ser Pro Glu Glu Leu Tyr Arg 
    210                 215                 220                 


Val Phe Thr Thr Gln Glu Leu Val Gln Ala Phe Thr His Ala Pro Ala 
225                 230                 235                 240 


Thr Leu Glu Ala Asp Arg Gly Gly Lys Phe His Met Val Asp Gly Asn 
                245                 250                 255     


Val Ser Gly Glu Phe Thr Asp Leu Val Pro Glu Lys His Ile Val Met 
            260                 265                 270         


Lys Trp Arg Phe Lys Ser Trp Pro Glu Gly Ser His Cys His Ser Gly 
        275                 280                 285             


<210> 8703
<211> 350
<212> PRT
<213> Homo sapiens

<400> 8703
Met Pro Ser Phe Ile Arg His Gly Pro Thr Ile Pro Arg Arg Thr Asp 
1               5                   10                  15      


Ile Cys Leu Pro Asp Ser Ser Pro Asn Ala Phe Ser Thr Ser Gly Asp 
            20                  25                  30          


Val Val Ser Arg Asn Gln Ser Phe Leu Arg Thr Pro Ile Gln Arg Thr 
        35                  40                  45              


Pro His Glu Ile Met Arg Arg Glu Ser Asn Arg Leu Ser Ala Pro Ser 
    50                  55                  60                  


Tyr Leu Ala Arg Ser Leu Ala Asp Val Pro Arg Glu Tyr Gly Ser Ser 
65                  70                  75                  80  


Gln Ser Phe Val Thr Glu Val Ser Phe Ala Val Glu Asn Gly Asp Ser 
                85                  90                  95      


Gly Ser Arg Tyr Tyr Tyr Ser Asp Asn Phe Phe Asp Gly Gln Arg Lys 
            100                 105                 110         


Arg Pro Leu Gly Asp Arg Ala His Glu Asp Tyr Arg Tyr Tyr Glu Tyr 
        115                 120                 125             


Asn His Asp Leu Phe Gln Arg Met Pro Gln Asn Gln Gly Arg His Ala 
    130                 135                 140                 


Ser Gly Ile Gly Arg Val Ala Ala Thr Ser Leu Gly Asn Leu Thr Asn 
145                 150                 155                 160 


His Gly Ser Glu Asp Leu Pro Leu Pro Pro Gly Trp Ser Val Asp Trp 
                165                 170                 175     


Thr Met Arg Gly Arg Lys Tyr Tyr Ile Asp His Asn Thr Asn Thr Thr 
            180                 185                 190         


His Trp Ser His Pro Leu Glu Arg Glu Gly Leu Pro Pro Gly Trp Glu 
        195                 200                 205             


Arg Val Glu Ser Ser Glu Phe Gly Thr Tyr Tyr Val Asp His Thr Asn 
    210                 215                 220                 


Lys Lys Ala Gln Tyr Arg His Pro Cys Ala Pro Ser Val Pro Arg Tyr 
225                 230                 235                 240 


Asp Gln Pro Pro Pro Val Thr Tyr Gln Pro Gln Gln Thr Glu Arg Asn 
                245                 250                 255     


Gln Ser Leu Leu Val Pro Ala Asn Pro Tyr His Thr Ala Glu Ile Pro 
            260                 265                 270         


Asp Trp Leu Gln Val Tyr Ala Arg Ala Pro Val Lys Tyr Asp His Ile 
        275                 280                 285             


Leu Lys Trp Glu Leu Phe Gln Leu Ala Asp Leu Asp Thr Tyr Gln Gly 
    290                 295                 300                 


Met Leu Lys Leu Leu Phe Met Lys Glu Leu Glu Gln Ile Val Lys Met 
305                 310                 315                 320 


Tyr Glu Ala Tyr Arg Gln Ala Leu Leu Thr Glu Leu Glu Asn Arg Lys 
                325                 330                 335     


Gln Arg Gln Gln Trp Tyr Ala Gln Gln His Gly Lys Asn Phe 
            340                 345                 350 


<210> 8704
<211> 178
<212> PRT
<213> Homo sapiens

<400> 8704
Met Thr Phe Arg Glu Gly His Gln Trp Glu Lys Ile Pro Leu Ser Gly 
1               5                   10                  15      


Ser Asn Gln Glu Ile Arg Arg Gln Lys Glu Arg Ile Thr Glu Gln Pro 
            20                  25                  30          


Leu Lys Glu Glu Glu Asp Glu Asp Arg Lys Asn Lys Gly His Gln Ala 
        35                  40                  45              


Ala Glu Ile Glu Trp Leu Gly Phe Arg Lys Pro Ser Gln Ala Asp Met 
    50                  55                  60                  


Leu His Ser Lys His Asp Glu Glu Gln Lys Val Trp Asp Glu Glu Ile 
65                  70                  75                  80  


Asp Asp Asp Asp Asp Asp Asn Cys Asn Asn Asp Glu Asp Glu Val Arg 
                85                  90                  95      


Val Ile Glu Phe Lys Lys Lys His Glu Glu Val Ser Gln Phe Lys Glu 
            100                 105                 110         


Glu Gly Asp Ala Ser Glu Asp Ser Pro Leu Ser Ser Ala Ser Ser Gln 
        115                 120                 125             


Ala Val Thr Pro Asp Glu Gln Pro Thr Leu Gly Lys Lys Ser Asp Ile 
    130                 135                 140                 


Ser Arg Asn Ala Tyr Ser Arg Tyr Asn Thr Ile Ser Tyr Arg Lys Ile 
145                 150                 155                 160 


Arg Lys Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser Met Met 
                165                 170                 175     


His Leu 
        


<210> 8705
<211> 103
<212> PRT
<213> Homo sapiens

<400> 8705
Met Ala Ala Phe Lys Leu Asp Phe Leu Pro Glu Met Met Val Asp His 
1               5                   10                  15      


Cys Ser Leu Asn Ser Ser Pro Val Ser Lys Lys Met Asn Gly Thr Leu 
            20                  25                  30          


Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile Lys Met Phe Val Gly 
        35                  40                  45              


Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu Arg Glu Leu Phe Glu 
    50                  55                  60                  


Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu Arg Asp Arg Ser Gln 
65                  70                  75                  80  


Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val Thr Phe Tyr Thr Arg 
                85                  90                  95      


Lys Ala Ala Leu Glu Ala Gln 
            100             


<210> 8706
<211> 638
<212> PRT
<213> Homo sapiens

<400> 8706
Met Pro Pro Ile Asn Leu Gln Glu Lys Gln Val Ile Cys Leu Ser Gly 
1               5                   10                  15      


Asp Asp Ser Ser Thr Cys Ile Gly Ile Leu Ala Lys Glu Val Glu Ile 
            20                  25                  30          


Val Ala Ser Ser Asp Ser Ser Ile Ser Ser Lys Ala Arg Gly Ser Asn 
        35                  40                  45              


Lys Val Lys Ile Gln Pro Val Ala Lys Tyr Asp Trp Glu Gln Lys Tyr 
    50                  55                  60                  


Tyr Tyr Gly Asn Leu Ile Ala Val Ser Asn Ser Phe Leu Ala Tyr Ala 
65                  70                  75                  80  


Ile Arg Ala Ala Asn Asn Gly Ser Ala Met Val Arg Val Ile Ser Val 
                85                  90                  95      


Ser Thr Ser Glu Arg Thr Leu Leu Lys Gly Phe Thr Gly Ser Val Ala 
            100                 105                 110         


Asp Leu Ala Phe Ala His Leu Asn Ser Pro Gln Leu Ala Cys Leu Asp 
        115                 120                 125             


Glu Ala Gly Asn Leu Phe Val Trp Arg Leu Ala Leu Val Asn Gly Lys 
    130                 135                 140                 


Ile Gln Glu Glu Ile Leu Val His Ile Arg Gln Pro Glu Gly Thr Pro 
145                 150                 155                 160 


Leu Asn His Phe Arg Arg Ile Ile Trp Cys Pro Phe Ile Pro Glu Glu 
                165                 170                 175     


Ser Glu Asp Cys Cys Glu Glu Ser Ser Pro Thr Val Ala Leu Leu His 
            180                 185                 190         


Glu Asp Arg Ala Glu Val Trp Asp Leu Asp Met Leu Arg Ser Ser His 
        195                 200                 205             


Ser Thr Trp Pro Val Asp Val Ser Gln Ile Lys Gln Gly Phe Ile Val 
    210                 215                 220                 


Val Lys Gly His Ser Thr Cys Leu Ser Glu Gly Ala Leu Ser Pro Asp 
225                 230                 235                 240 


Gly Thr Val Leu Ala Thr Ala Ser His Asp Gly Tyr Val Lys Phe Trp 
                245                 250                 255     


Gln Ile Tyr Ile Glu Gly Gln Asp Glu Pro Arg Cys Leu His Glu Trp 
            260                 265                 270         


Lys Pro His Asp Gly Arg Pro Leu Ser Cys Leu Leu Phe Cys Asp Asn 
        275                 280                 285             


His Lys Lys Gln Asp Pro Asp Val Pro Phe Trp Arg Phe Leu Ile Thr 
    290                 295                 300                 


Gly Ala Asp Gln Asn Arg Glu Leu Lys Met Trp Cys Thr Val Ser Trp 
305                 310                 315                 320 


Thr Cys Leu Gln Thr Ile Arg Phe Ser Pro Asp Ile Phe Ser Ser Val 
                325                 330                 335     


Ser Val Pro Pro Ser Leu Lys Val Cys Leu Asp Leu Ser Ala Glu Tyr 
            340                 345                 350         


Leu Ile Leu Ser Asp Val Gln Arg Lys Val Leu Tyr Val Met Glu Leu 
        355                 360                 365             


Leu Gln Asn Gln Glu Glu Gly His Ala Cys Phe Ser Ser Ile Ser Glu 
    370                 375                 380                 


Phe Leu Leu Thr His Pro Val Leu Ser Phe Gly Ile Gln Val Val Ser 
385                 390                 395                 400 


Arg Cys Arg Leu Arg His Thr Glu Val Leu Pro Ala Glu Glu Glu Asn 
                405                 410                 415     


Asp Ser Leu Gly Ala Asp Gly Thr His Gly Ala Gly Ala Met Glu Ser 
            420                 425                 430         


Ala Ala Gly Val Leu Ile Lys Leu Phe Cys Val His Thr Lys Ala Leu 
        435                 440                 445             


Gln Asp Val Gln Ile Arg Phe Gln Pro Gln Leu Asn Pro Asp Val Val 
    450                 455                 460                 


Ala Pro Leu Pro Thr His Thr Ala His Glu Asp Phe Thr Phe Gly Glu 
465                 470                 475                 480 


Ser Arg Pro Glu Leu Gly Ser Glu Gly Leu Gly Ser Ala Ala His Gly 
                485                 490                 495     


Ser Gln Pro Asp Leu Arg Arg Ile Val Glu Leu Pro Ala Pro Ala Asp 
            500                 505                 510         


Phe Leu Ser Leu Ser Ser Glu Thr Lys Pro Lys Leu Met Thr Pro Asp 
        515                 520                 525             


Ala Phe Met Thr Pro Ser Ala Ser Leu Gln Gln Ile Thr Ala Ser Pro 
    530                 535                 540                 


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
545                 550                 555                 560 


Ser Leu Thr Ala Val Ser Ala Met Ser Ser Thr Ser Ala Val Asp Pro 
                565                 570                 575     


Ser Leu Thr Arg Pro Pro Glu Glu Leu Thr Leu Ser Pro Lys Leu Gln 
            580                 585                 590         


Leu Asp Gly Ser Leu Thr Met Ser Ser Ser Gly Ser Leu Gln Ala Ser 
        595                 600                 605             


Pro Arg Gly Leu Leu Pro Gly Leu Leu Pro Ala Pro Ala Asp Lys Leu 
    610                 615                 620                 


Thr Pro Lys Gly Pro Gly Gln Val Cys Asp Trp Val Cys Val 
625                 630                 635             


<210> 8707
<211> 164
<212> PRT
<213> Homo sapiens

<400> 8707
Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr Ile 
1               5                   10                  15      


Leu Tyr Arg Leu Gln Val Gly Glu Val Val Thr Thr Ile Pro Thr Ile 
            20                  25                  30          


Gly Phe Asn Val Glu Thr Val Thr Tyr Lys Asn Leu Lys Phe Gln Val 
        35                  40                  45              


Trp Asp Leu Gly Gly Gln Thr Ser Ile Arg Pro Tyr Trp Arg Cys Tyr 
    50                  55                  60                  


Tyr Ser Asn Thr Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp Arg 
65                  70                  75                  80  


Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu Glu 
                85                  90                  95      


Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln Asp 
            100                 105                 110         


Met Glu Gln Ala Met Thr Ser Ser Glu Met Ala Asn Ser Leu Gly Leu 
        115                 120                 125             


Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Thr Ser Ala Thr 
    130                 135                 140                 


Lys Gly Thr Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Thr Leu 
145                 150                 155                 160 


Lys Ser Arg Gln 
                


<210> 8708
<211> 647
<212> PRT
<213> Homo sapiens

<400> 8708
Met Ala Gln Gly Ser Val Ser Phe Asn Asp Val Thr Val Asp Phe Thr 
1               5                   10                  15      


Gln Glu Glu Trp Gln His Leu Asp His Ala Gln Lys Thr Leu Tyr Met 
            20                  25                  30          


Asp Val Met Leu Glu Asn Tyr Cys His Leu Ile Ser Val Gly Cys His 
        35                  40                  45              


Met Thr Lys Pro Asp Val Ile Leu Lys Leu Glu Arg Gly Glu Glu Pro 
    50                  55                  60                  


Trp Thr Ser Phe Ala Gly His Thr Cys Leu Glu Glu Asn Trp Lys Ala 
65                  70                  75                  80  


Glu Asp Phe Leu Val Lys Phe Lys Glu His Gln Glu Lys Tyr Ser Arg 
                85                  90                  95      


Ser Val Val Ser Ile Asn His Lys Lys Leu Val Lys Glu Lys Ser Lys 
            100                 105                 110         


Ile Tyr Glu Lys Thr Phe Thr Leu Gly Lys Asn Pro Val Asn Ser Lys 
        115                 120                 125             


Asn Leu Pro Pro Glu Tyr Asp Thr His Gly Arg Ile Leu Lys Asn Val 
    130                 135                 140                 


Ser Glu Leu Ile Ile Ser Asn Leu Asn Pro Ala Arg Lys Arg Leu Ser 
145                 150                 155                 160 


Glu Tyr Asn Gly Tyr Gly Lys Ser Leu Leu Ser Thr Lys Gln Glu Thr 
                165                 170                 175     


Thr His Pro Glu Val Lys Ser His Asn Gln Ser Ala Arg Ala Phe Ser 
            180                 185                 190         


His Asn Glu Val Leu Met Gln Tyr Gln Lys Thr Glu Thr Pro Ala Gln 
        195                 200                 205             


Ser Phe Gly Tyr Asn Asp Cys Glu Lys Ser Phe Leu Gln Arg Gly Gly 
    210                 215                 220                 


Leu Ile Thr His Ser Arg Pro Tyr Lys Gly Glu Asn Pro Ser Val Tyr 
225                 230                 235                 240 


Asn Lys Lys Arg Arg Ala Thr Asn Ile Glu Lys Lys His Thr Cys Asn 
                245                 250                 255     


Glu Cys Gly Lys Ser Phe Cys Arg Lys Ser Val Leu Ile Leu His Gln 
            260                 265                 270         


Gly Ile His Ser Glu Glu Lys Pro Tyr Gln Cys His Gln Cys Gly Asn 
        275                 280                 285             


Ala Phe Arg Arg Lys Ser Tyr Leu Ile Asp His Gln Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Phe Val Cys Asn Glu Cys Gly Lys Ser Phe Arg Leu 
305                 310                 315                 320 


Lys Thr Ala Leu Thr Asp His Gln Arg Thr His Thr Gly Glu Lys Ser 
                325                 330                 335     


Tyr Glu Cys Leu Gln Cys Arg Asn Ala Phe Arg Leu Lys Ser His Leu 
            340                 345                 350         


Ile Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn 
        355                 360                 365             


Asp Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu Ser Leu His Gln 
    370                 375                 380                 


Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Lys Glu Cys Gly Lys 
385                 390                 395                 400 


Ser Phe His Gln Lys Ala Asn Leu Thr Val His Gln Arg Thr His Thr 
                405                 410                 415     


Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Ser Gln 
            420                 425                 430         


Lys Thr Thr Leu Ala Leu His Glu Lys Thr His Asn Glu Glu Lys Pro 
        435                 440                 445             


Tyr Ile Cys Ser Glu Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu 
    450                 455                 460                 


Val Ala His Gln Arg Thr His Thr Gly Glu Lys Ser Tyr Glu Cys Pro 
465                 470                 475                 480 


His Cys Gly Lys Ala Phe Arg Met Lys Ser Tyr Leu Ile Asp His His 
                485                 490                 495     


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys 
            500                 505                 510         


Ser Phe Ser Gln Lys Thr Asn Leu Asn Leu His Gln Arg Ile His Thr 
        515                 520                 525             


Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ser Phe Arg Gln 
    530                 535                 540                 


Lys Ala Thr Leu Thr Val His Gln Lys Ile His Thr Gly Gln Lys Ser 
545                 550                 555                 560 


Tyr Glu Cys Pro Gln Cys Gly Lys Ala Phe Ser Arg Lys Ser Tyr Leu 
                565                 570                 575     


Ile His His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser 
            580                 585                 590         


Glu Cys Gly Lys Cys Phe Arg Gln Lys Thr Asn Leu Ile Val His Gln 
        595                 600                 605             


Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys 
    610                 615                 620                 


Ser Phe Ser Tyr Lys Arg Asn Leu Ile Val His Gln Arg Thr His Lys 
625                 630                 635                 640 


Gly Glu Asn Ile Glu Met Gln 
                645         


<210> 8709
<211> 1189
<212> PRT
<213> Homo sapiens

<400> 8709
Met Lys Leu Glu Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr Val Pro 
1               5                   10                  15      


Ser Phe Pro Pro Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro His Thr 
            20                  25                  30          


Pro Val Ile Val Pro Ala Ala Ala Thr Thr Val Ser Ser Pro Ser Ala 
        35                  40                  45              


Ala Ile Thr Val Gln Arg Val Leu Glu Glu Asp Glu Ser Ile Arg Thr 
    50                  55                  60                  


Cys Leu Ser Glu Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu Val Glu 
65                  70                  75                  80  


Ala Asp Gly Gln Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser 
                85                  90                  95      


Arg Arg Ser Pro Val Pro Ala Gln Ile Ala Ile Thr Val Pro Lys Thr 
            100                 105                 110         


Trp Lys Lys Pro Lys Asp Arg Thr Arg Thr Thr Glu Glu Met Leu Glu 
        115                 120                 125             


Ala Glu Leu Glu Leu Lys Ala Glu Glu Glu Leu Ser Ile Asp Lys Val 
    130                 135                 140                 


Leu Glu Ser Glu Gln Asp Lys Met Ser Gln Gly Phe His Pro Glu Arg 
145                 150                 155                 160 


Asp Pro Ser Asp Leu Lys Lys Val Lys Ala Val Glu Glu Asn Gly Glu 
                165                 170                 175     


Glu Ala Glu Pro Val Arg Asn Gly Ala Glu Ser Val Ser Glu Gly Glu 
            180                 185                 190         


Gly Ile Asp Ala Asn Ser Gly Ser Thr Asp Ser Ser Gly Asp Gly Val 
        195                 200                 205             


Thr Phe Pro Phe Lys Pro Glu Ser Trp Lys Pro Thr Asp Thr Glu Gly 
    210                 215                 220                 


Lys Lys Gln Tyr Asp Arg Glu Phe Leu Leu Asp Phe Gln Phe Met Pro 
225                 230                 235                 240 


Ala Cys Ile Gln Lys Pro Glu Gly Leu Pro Pro Ile Ser Asp Val Val 
                245                 250                 255     


Leu Asp Lys Ile Asn Gln Pro Lys Leu Pro Met Arg Thr Leu Asp Pro 
            260                 265                 270         


Arg Ile Leu Pro Arg Gly Pro Asp Phe Thr Pro Ala Phe Ala Asp Phe 
        275                 280                 285             


Gly Arg Gln Thr Pro Gly Gly Arg Gly Val Pro Leu Leu Asn Val Gly 
    290                 295                 300                 


Ser Arg Arg Ser Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys Ile Ile 
305                 310                 315                 320 


Thr Val Ser Val Lys Glu Asp Val His Leu Lys Lys Ala Glu Asn Ala 
                325                 330                 335     


Trp Lys Pro Ser Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro Glu Asn 
            340                 345                 350         


Ile Lys Thr Gln Glu Leu Phe Arg Lys Val Arg Ser Ile Leu Asn Lys 
        355                 360                 365             


Leu Thr Pro Gln Met Phe Asn Gln Leu Met Lys Gln Val Ser Gly Leu 
    370                 375                 380                 


Thr Val Asp Thr Glu Glu Arg Leu Lys Gly Val Ile Asp Leu Val Phe 
385                 390                 395                 400 


Glu Lys Ala Ile Asp Glu Pro Ser Phe Ser Val Ala Tyr Ala Asn Met 
                405                 410                 415     


Cys Arg Cys Leu Val Thr Leu Lys Val Pro Met Ala Asp Lys Pro Gly 
            420                 425                 430         


Asn Thr Val Asn Phe Arg Lys Leu Leu Leu Asn Arg Cys Gln Lys Glu 
        435                 440                 445             


Phe Glu Lys Asp Lys Ala Asp Asp Asp Val Phe Glu Lys Lys Gln Lys 
    450                 455                 460                 


Glu Leu Glu Ala Ala Ser Ala Pro Glu Glu Arg Thr Arg Leu His Asp 
465                 470                 475                 480 


Glu Leu Glu Glu Ala Lys Asp Lys Ala Arg Arg Arg Ser Ile Gly Asn 
                485                 490                 495     


Ile Lys Phe Ile Gly Glu Leu Phe Lys Leu Lys Met Leu Thr Glu Ala 
            500                 505                 510         


Ile Met His Asp Cys Val Val Lys Leu Leu Lys Asn His Asp Glu Glu 
        515                 520                 525             


Ser Leu Glu Cys Leu Cys Arg Leu Leu Thr Thr Ile Gly Lys Asp Leu 
    530                 535                 540                 


Asp Phe Glu Lys Ala Lys Pro Arg Met Asp Gln Tyr Phe Asn Gln Met 
545                 550                 555                 560 


Glu Lys Ile Val Lys Glu Arg Lys Thr Ser Ser Arg Ile Arg Phe Met 
                565                 570                 575     


Leu Gln Asp Val Ile Asp Leu Arg Leu Cys Asn Trp Val Ser Arg Arg 
            580                 585                 590         


Ala Asp Gln Gly Pro Lys Thr Ile Glu Gln Ile His Lys Glu Ala Lys 
        595                 600                 605             


Ile Glu Glu Gln Glu Glu Gln Arg Lys Val Gln Gln Leu Met Thr Lys 
    610                 615                 620                 


Glu Lys Arg Arg Pro Gly Val Gln Arg Val Asp Glu Gly Gly Trp Asn 
625                 630                 635                 640 


Thr Val Gln Gly Ala Lys Asn Ser Arg Val Leu Asp Pro Ser Lys Phe 
                645                 650                 655     


Leu Lys Ile Thr Lys Pro Thr Ile Asp Glu Lys Ile Gln Leu Val Pro 
            660                 665                 670         


Lys Ala Gln Leu Gly Ser Trp Gly Lys Gly Ser Ser Gly Gly Ala Lys 
        675                 680                 685             


Ala Ser Glu Thr Asp Ala Leu Arg Ser Ser Ala Ser Ser Leu Asn Arg 
    690                 695                 700                 


Phe Ser Ala Leu Gln Pro Pro Ala Pro Ser Gly Ser Thr Pro Ser Thr 
705                 710                 715                 720 


Pro Val Glu Phe Asp Ser Arg Arg Thr Leu Thr Ser Arg Gly Ser Met 
                725                 730                 735     


Gly Arg Glu Lys Asn Asp Lys Pro Leu Pro Ser Ala Thr Ala Arg Pro 
            740                 745                 750         


Asn Thr Phe Met Arg Gly Gly Ser Ser Lys Asp Leu Leu Asp Asn Gln 
        755                 760                 765             


Ser Gln Glu Glu Gln Arg Arg Glu Met Leu Glu Thr Val Lys Gln Leu 
    770                 775                 780                 


Thr Gly Gly Val Asp Val Glu Arg Asn Ser Thr Glu Ala Glu Arg Asn 
785                 790                 795                 800 


Lys Thr Arg Glu Ser Ala Lys Pro Glu Ile Ser Ala Met Ser Ala His 
                805                 810                 815     


Asp Lys Ala Ala Leu Ser Glu Glu Glu Leu Glu Arg Lys Ser Lys Ser 
            820                 825                 830         


Ile Ile Asp Glu Phe Leu His Ile Asn Asp Phe Lys Glu Ala Met Gln 
        835                 840                 845             


Cys Val Glu Glu Leu Asn Ala Gln Gly Leu Leu His Val Phe Val Arg 
    850                 855                 860                 


Val Gly Val Glu Ser Thr Leu Glu Arg Ser Gln Ile Thr Arg Asp His 
865                 870                 875                 880 


Met Gly Gln Leu Leu Tyr Gln Leu Val Gln Ser Glu Lys Leu Ser Lys 
                885                 890                 895     


Gln Asp Phe Phe Lys Gly Phe Ser Glu Thr Leu Glu Leu Ala Asp Asp 
            900                 905                 910         


Met Ala Ile Asp Ile Pro His Ile Trp Leu Tyr Leu Ala Glu Leu Val 
        915                 920                 925             


Thr Pro Met Leu Lys Glu Gly Gly Ile Ser Met Arg Glu Leu Thr Ile 
    930                 935                 940                 


Glu Phe Ser Lys Pro Leu Leu Pro Val Gly Arg Ala Gly Val Leu Leu 
945                 950                 955                 960 


Ser Glu Ile Leu His Leu Leu Cys Lys Gln Met Ser His Lys Lys Val 
                965                 970                 975     


Gly Ala Leu Trp Arg Glu Ala Asp Leu Ser Trp Lys Asp Phe Leu Pro 
            980                 985                 990         


Glu Gly Glu Asp Val His Asn Phe  Leu Leu Glu Gln Lys  Leu Asp Phe 
        995                 1000                 1005             


Ile Glu  Ser Asp Ser Pro Cys  Ser Ser Glu Ala Leu  Ser Lys Lys 
    1010                 1015                 1020             


Glu Leu  Ser Ala Glu Glu Leu  Tyr Lys Arg Leu Glu  Lys Leu Ile 
    1025                 1030                 1035             


Ile Glu  Asp Lys Ala Asn Asp  Glu Gln Ile Phe Asp  Trp Val Glu 
    1040                 1045                 1050             


Ala Asn  Leu Asp Glu Ile Gln  Met Ser Ser Pro Thr  Phe Leu Arg 
    1055                 1060                 1065             


Ala Leu  Met Thr Ala Val Cys  Lys Ala Ala Ile Ile  Ala Asp Ser 
    1070                 1075                 1080             


Ser Thr  Phe Arg Val Asp Thr  Ala Val Ile Lys Gln  Arg Val Pro 
    1085                 1090                 1095             


Ile Leu  Leu Lys Tyr Leu Asp  Ser Asp Thr Glu Lys  Glu Leu Gln 
    1100                 1105                 1110             


Ala Leu  Tyr Ala Leu Gln Ala  Ser Ile Val Lys Leu  Asp Gln Pro 
    1115                 1120                 1125             


Ala Asn  Leu Leu Arg Met Phe  Phe Asp Cys Leu Tyr  Asp Glu Glu 
    1130                 1135                 1140             


Val Ile  Ser Glu Asp Ala Phe  Tyr Lys Trp Glu Ser  Ser Lys Asp 
    1145                 1150                 1155             


Pro Ala  Glu Gln Asn Gly Lys  Gly Val Ala Leu Lys  Ser Val Thr 
    1160                 1165                 1170             


Ala Phe  Phe Thr Trp Leu Arg  Glu Ala Glu Glu Glu  Ser Glu Asp 
    1175                 1180                 1185             


Asn 
    


<210> 8710
<211> 196
<212> PRT
<213> Homo sapiens

<400> 8710
Met Trp Ser Val Leu Gln Asp Gly Pro Ile Ser Arg Val Ile Val Phe 
1               5                   10                  15      


Ser Leu Ser Ala Ala Lys Glu Thr Lys Asp Arg Pro Leu Gln Asp Glu 
            20                  25                  30          


Tyr Ser Val Leu Val Ala Ser Met Leu Glu Pro Ala Val Val Tyr Arg 
        35                  40                  45              


Asp Leu Leu Asn Arg Gly Leu Glu Asp Gln Leu Leu Leu Pro Gly Ser 
    50                  55                  60                  


Asp Gln Phe Asp Ser Val Leu Cys Ser Leu Val Thr Asp Val Asp Leu 
65                  70                  75                  80  


Asp Gly Arg Pro Glu Val Leu Val Ala Thr Tyr Gly Gln Glu Leu Leu 
                85                  90                  95      


Cys Tyr Lys Tyr Arg Gly Pro Glu Ser Gly Leu Pro Glu Ala Gln His 
            100                 105                 110         


Gly Phe His Leu Leu Trp Gln Arg Ser Phe Ser Ser Pro Leu Leu Ala 
        115                 120                 125             


Met Ala His Val Asp Leu Thr Gly Asp Gly Leu Gln Glu Leu Ala Val 
    130                 135                 140                 


Val Ser Leu Lys Gly Val His Ile Leu Gln His Ser Leu Ile Gln Ala 
145                 150                 155                 160 


Ser Glu Leu Val Leu Thr Arg Leu Arg His Gln Val Glu Gln Arg Arg 
                165                 170                 175     


Arg Arg Leu Gln Gly Leu Glu Asp Gly Ala Gly Ala Gly Pro Ala Glu 
            180                 185                 190         


Asn Ala Ala Ser 
        195     


<210> 8711
<211> 351
<212> PRT
<213> Homo sapiens

<400> 8711
Met Val Ser His Thr Phe His Met Arg Thr Glu Glu Ser Asp Ala Ser 
1               5                   10                  15      


Gln Glu Gly Asp Asp Leu Pro Lys Ser Ser Ala Asn Thr Ser His Pro 
            20                  25                  30          


Lys Gln Asp Asp Ser Pro Lys Ser Ser Glu Glu Thr Ile Gln Pro Lys 
        35                  40                  45              


Glu Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys 
    50                  55                  60                  


Glu Asp Leu Pro Lys Ser Ser Glu Lys Ala Ile Gln Pro Lys Glu Ser 
65                  70                  75                  80  


Asn Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn 
                85                  90                  95      


Ile Pro Lys Thr Ser Val Lys Pro Ser Gln Pro Lys Glu Ser Asp Ile 
            100                 105                 110         


Pro Lys Ser Pro Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro 
        115                 120                 125             


Lys Ser Leu Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys 
    130                 135                 140                 


Ser Pro Glu Glu Thr Ile Gln Pro Lys Lys Gly Asp Ile Pro Lys Ser 
145                 150                 155                 160 


Pro Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro 
                165                 170                 175     


Lys Gln Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu 
            180                 185                 190         


Glu Ala Ile Pro Pro Lys Glu Ile Asp Ile Pro Lys Ser Pro Glu Glu 
        195                 200                 205             


Thr Ile Gln Pro Lys Glu Asp Asp Ser Pro Lys Ser Leu Glu Glu Ala 
    210                 215                 220                 


Thr Pro Ser Lys Glu Gly Asp Ile Leu Lys Pro Glu Glu Glu Thr Met 
225                 230                 235                 240 


Glu Phe Pro Glu Gly Asp Lys Val Lys Val Ile Leu Ser Lys Glu Asp 
                245                 250                 255     


Phe Glu Ala Ser Leu Lys Glu Ala Gly Glu Arg Leu Val Ala Val Asp 
            260                 265                 270         


Phe Ser Ala Thr Trp Cys Gly Pro Cys Arg Thr Ile Arg Pro Phe Phe 
        275                 280                 285             


His Ala Leu Ser Val Lys His Glu Asp Val Val Phe Leu Glu Val Asp 
    290                 295                 300                 


Ala Asp Asn Cys Glu Glu Val Val Arg Glu Cys Ala Ile Met Cys Val 
305                 310                 315                 320 


Pro Thr Phe Gln Phe Tyr Lys Lys Glu Glu Lys Val Asp Glu Leu Cys 
                325                 330                 335     


Gly Ala Leu Lys Glu Lys Leu Glu Ala Val Ile Ala Glu Leu Lys 
            340                 345                 350     


<210> 8712
<211> 490
<212> PRT
<213> Homo sapiens

<400> 8712
Met Pro Asp Gly Lys Ile Gln Lys Leu Ile Ile Thr Glu Glu Thr Ala 
1               5                   10                  15      


Lys Ile Arg Pro Phe Ala Val Ala Ala Val Leu Arg Asn Ile Lys Phe 
            20                  25                  30          


Thr Lys Asp Arg Tyr Asp Ser Phe Ile Glu Leu Gln Glu Lys Leu His 
        35                  40                  45              


Gln Asn Ile Cys Arg Lys Arg Ala Leu Val Ala Ile Gly Thr His Asp 
    50                  55                  60                  


Leu Asp Thr Leu Ser Gly Pro Phe Thr Tyr Thr Ala Lys Arg Pro Ser 
65                  70                  75                  80  


Asp Ile Lys Phe Lys Pro Leu Asn Lys Thr Lys Glu Tyr Thr Ala Cys 
                85                  90                  95      


Glu Leu Met Asn Ile Tyr Lys Thr Asp Asn His Leu Lys His Tyr Leu 
            100                 105                 110         


His Ile Ile Glu Asn Lys Pro Leu Tyr Pro Val Ile Tyr Asp Ser Asn 
        115                 120                 125             


Gly Val Val Leu Ser Met Pro Pro Ile Ile Asn Gly Asp His Ser Arg 
    130                 135                 140                 


Ile Thr Val Asn Thr Arg Asn Ile Phe Ile Glu Cys Thr Gly Thr Asp 
145                 150                 155                 160 


Phe Thr Lys Ala Lys Ile Val Leu Asp Ile Ile Val Thr Met Phe Ser 
                165                 170                 175     


Glu Tyr Cys Glu Asn Gln Phe Thr Val Glu Ala Ala Glu Val Val Phe 
            180                 185                 190         


Pro Asn Gly Lys Ser His Thr Phe Pro Glu Leu Ala Tyr Arg Lys Glu 
        195                 200                 205             


Met Val Arg Ala Asp Leu Ile Asn Lys Lys Val Gly Ile Arg Glu Thr 
    210                 215                 220                 


Pro Glu Asn Leu Ala Lys Leu Leu Thr Arg Met Tyr Leu Lys Ser Glu 
225                 230                 235                 240 


Val Ile Gly Asp Gly Asn Gln Ile Glu Ile Glu Ile Pro Pro Thr Arg 
                245                 250                 255     


Ala Asp Ile Ile His Ala Cys Asp Ile Val Glu Asp Ala Ala Ile Ala 
            260                 265                 270         


Tyr Gly Tyr Asn Asn Ile Gln Met Thr Leu Pro Lys Thr Tyr Thr Ile 
        275                 280                 285             


Ala Asn Gln Phe Pro Leu Asn Lys Leu Thr Glu Leu Leu Arg His Asp 
    290                 295                 300                 


Met Ala Ala Ala Gly Phe Thr Glu Ala Leu Thr Phe Ala Leu Cys Ser 
305                 310                 315                 320 


Gln Glu Asp Ile Ala Asp Lys Leu Gly Val Asp Ile Ser Ala Thr Lys 
                325                 330                 335     


Ala Val His Ile Ser Asn Pro Lys Thr Ala Glu Phe Gln Val Ala Arg 
            340                 345                 350         


Thr Thr Leu Leu Pro Gly Leu Leu Lys Thr Ile Ala Ala Asn Arg Lys 
        355                 360                 365             


Met Pro Leu Pro Leu Lys Leu Phe Glu Ile Ser Asp Ile Val Ile Lys 
    370                 375                 380                 


Asp Ser Asn Thr Asp Val Gly Ala Lys Asn Tyr Arg His Leu Cys Ala 
385                 390                 395                 400 


Val Tyr Tyr Asn Lys Asn Pro Gly Phe Glu Ile Ile His Gly Leu Leu 
                405                 410                 415     


Asp Arg Ile Met Gln Leu Leu Asp Val Pro Pro Gly Glu Asp Lys Gly 
            420                 425                 430         


Gly Tyr Val Ile Lys Ala Ser Glu Gly Pro Ala Phe Phe Pro Gly Arg 
        435                 440                 445             


Cys Ala Glu Ile Phe Ala Arg Gly Gln Ser Val Gly Lys Leu Gly Val 
    450                 455                 460                 


Leu His Pro Asp Val Ile Thr Lys Phe Glu Leu Thr Met Pro Cys Ser 
465                 470                 475                 480 


Ser Leu Glu Ile Asn Val Gly Pro Phe Leu 
                485                 490 


<210> 8713
<211> 485
<212> PRT
<213> Homo sapiens

<400> 8713
Met Ala Ala Glu Leu Tyr Ala Pro Ala Ser Ala Ala Ala Ala Asp Leu 
1               5                   10                  15      


Ala Asn Ser Asn Ala Gly Ala Ala Val Gly Arg Lys Ala Gly Pro Arg 
            20                  25                  30          


Ser Pro Pro Ser Ala Pro Ala Pro Ala Pro Pro Pro Pro Ala Pro Ala 
        35                  40                  45              


Pro Pro Thr Leu Gly Asn Asn His Gln Glu Ser Pro Gly Trp Arg Cys 
    50                  55                  60                  


Cys Arg Pro Thr Leu Arg Glu Arg Asn Ala Leu Met Phe Asn Asn Glu 
65                  70                  75                  80  


Leu Met Ala Asp Val His Phe Val Val Gly Pro Pro Gly Ala Thr Arg 
                85                  90                  95      


Thr Val Pro Ala His Lys Tyr Val Leu Ala Val Gly Ser Ser Val Phe 
            100                 105                 110         


Tyr Ala Met Phe Tyr Gly Asp Leu Ala Glu Val Lys Ser Glu Ile His 
        115                 120                 125             


Ile Pro Asp Val Glu Pro Ala Ala Phe Leu Ile Leu Leu Lys Tyr Met 
    130                 135                 140                 


Tyr Ser Asp Glu Ile Asp Leu Glu Ala Asp Thr Val Leu Ala Thr Leu 
145                 150                 155                 160 


Tyr Ala Ala Lys Lys Tyr Ile Val Pro Ala Leu Ala Lys Ala Cys Val 
                165                 170                 175     


Asn Phe Leu Glu Thr Ser Leu Glu Ala Lys Asn Ala Cys Val Leu Leu 
            180                 185                 190         


Ser Gln Ser Arg Leu Phe Glu Glu Pro Glu Leu Thr Gln Arg Cys Trp 
        195                 200                 205             


Glu Val Ile Asp Ala Gln Ala Glu Met Ala Leu Arg Ser Glu Gly Phe 
    210                 215                 220                 


Cys Glu Ile Asp Arg Gln Thr Leu Glu Ile Ile Val Thr Arg Glu Ala 
225                 230                 235                 240 


Leu Asn Thr Lys Glu Ala Val Val Phe Glu Ala Val Leu Asn Trp Ala 
                245                 250                 255     


Glu Ala Glu Cys Lys Arg Gln Gly Leu Pro Ile Thr Pro Arg Asn Lys 
            260                 265                 270         


Arg His Val Leu Gly Arg Ala Leu Tyr Leu Val Arg Ile Pro Thr Met 
        275                 280                 285             


Thr Leu Glu Glu Phe Ala Asn Gly Ala Ala Gln Ser Asp Ile Leu Thr 
    290                 295                 300                 


Leu Glu Glu Thr His Ser Ile Phe Leu Trp Tyr Thr Ala Thr Asn Lys 
305                 310                 315                 320 


Pro Arg Leu Asp Phe Pro Leu Thr Lys Arg Lys Gly Leu Ala Pro Gln 
                325                 330                 335     


Arg Cys His Arg Phe Gln Ser Ser Ala Tyr Arg Ser Asn Gln Trp Arg 
            340                 345                 350         


Tyr Arg Gly Arg Cys Asp Ser Ile Gln Phe Ala Val Asp Arg Arg Val 
        355                 360                 365             


Phe Ile Ala Gly Leu Gly Leu Tyr Gly Ser Ser Ser Gly Lys Ala Glu 
    370                 375                 380                 


Tyr Ser Val Lys Ile Glu Leu Lys Arg Leu Gly Val Val Leu Ala Gln 
385                 390                 395                 400 


Asn Leu Thr Lys Phe Met Ser Asp Gly Ser Ser Asn Thr Phe Pro Val 
                405                 410                 415     


Trp Phe Glu His Pro Val Gln Val Glu Gln Asp Thr Phe Tyr Thr Ala 
            420                 425                 430         


Ser Ala Val Leu Asp Gly Ser Glu Leu Ser Tyr Phe Gly Gln Glu Gly 
        435                 440                 445             


Met Thr Glu Val Gln Cys Gly Lys Val Ala Phe Gln Phe Gln Cys Ser 
    450                 455                 460                 


Ser Asp Ser Thr Asn Gly Thr Gly Val Gln Gly Gly Gln Ile Pro Glu 
465                 470                 475                 480 


Leu Ile Phe Tyr Ala 
                485 


<210> 8714
<211> 67
<212> PRT
<213> Homo sapiens

<400> 8714
Met Ala Leu Leu Ala Glu His Leu Leu Lys Pro Leu Pro Ala Asp Lys 
1               5                   10                  15      


Gln Ile Glu Thr Gly Pro Phe Leu Glu Ala Val Ser His Leu Pro Pro 
            20                  25                  30          


Phe Phe Asp Cys Leu Gly Ser Pro Val Phe Thr Pro Ile Lys Ala Asp 
        35                  40                  45              


Ile Ser Gly Asn Ile Thr Met Arg Lys Leu Arg Leu Arg Gly Val Glu 
    50                  55                  60                  


Gly Leu Ala 
65          


<210> 8715
<211> 271
<212> PRT
<213> Homo sapiens

<400> 8715
Ile Cys Glu Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln 
1               5                   10                  15      


Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr 
            20                  25                  30          


Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile 
        35                  40                  45              


Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val 
    50                  55                  60                  


Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile 
65                  70                  75                  80  


Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys 
                85                  90                  95      


Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser 
            100                 105                 110         


Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp 
        115                 120                 125             


Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro 
    130                 135                 140                 


Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser 
145                 150                 155                 160 


Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg 
                165                 170                 175     


Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val 
            180                 185                 190         


Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe 
        195                 200                 205             


Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu 
    210                 215                 220                 


Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu 
225                 230                 235                 240 


Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile 
                245                 250                 255     


Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
            260                 265                 270     


<210> 8716
<211> 96
<212> PRT
<213> Homo sapiens

<400> 8716
Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met 
            20                  25                  30          


Asp Thr Ser Thr Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp 
        35                  40                  45              


Leu Glu Lys Ser Thr Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly 
    50                  55                  60                  


Glu Ser Phe Gly Gly Glu Thr Ser Asn Ser Gly Asp Pro His Lys Gly 
65                  70                  75                  80  


Phe Ser Val Asp Tyr Tyr Asn Thr Thr Thr Lys Gly Thr Pro Glu Arg 
                85                  90                  95      


<210> 8717
<211> 263
<212> PRT
<213> Homo sapiens

<400> 8717
Met Leu Ser Ser Lys Gly Leu Thr Val Val Asp Val Tyr Gln Gly Trp 
1               5                   10                  15      


Cys Gly Pro Cys Lys Pro Val Val Ser Leu Phe Gln Lys Met Arg Ile 
            20                  25                  30          


Glu Val Gly Leu Asp Leu Leu His Phe Ala Leu Ala Glu Ala Asp Arg 
        35                  40                  45              


Leu Asp Val Leu Glu Lys Tyr Arg Gly Lys Cys Glu Pro Thr Phe Leu 
    50                  55                  60                  


Phe Tyr Ala Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val 
65                  70                  75                  80  


Ser His Gly Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu 
                85                  90                  95      


Arg Thr Cys Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly 
            100                 105                 110         


Lys Thr Asp Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile 
        115                 120                 125             


Leu Thr Asn Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe 
    130                 135                 140                 


Tyr Gln His Lys Ala Gly Glu Glu Ala Phe Glu Lys Leu Val His His 
145                 150                 155                 160 


Met Cys Ser Gly Pro Ser His Leu Leu Ile Leu Thr Arg Thr Glu Gly 
                165                 170                 175     


Phe Glu Asp Val Val Thr Thr Trp Arg Thr Val Met Gly Pro Arg Asp 
            180                 185                 190         


Pro Asn Val Ala Arg Arg Glu Gln Pro Glu Ser Leu Arg Ala Gln Tyr 
        195                 200                 205             


Gly Thr Glu Met Pro Phe Asn Ala Val His Gly Ser Arg Asp Arg Glu 
    210                 215                 220                 


Asp Ala Asp Arg Glu Leu Ala Leu Leu Phe Pro Ser Leu Lys Phe Ser 
225                 230                 235                 240 


Asp Lys Asp Thr Glu Ala Pro Gln Gly Glu Ser Ser Thr Gln Pro Arg 
                245                 250                 255     


Leu Lys Ile Thr Asp Leu Asp 
            260             


<210> 8718
<211> 288
<212> PRT
<213> Homo sapiens

<400> 8718
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Thr Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Thr His Gly Thr Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Thr Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu Asp Gly Asn Arg Asp Thr Pro Leu His Trp Ala Ala Phe Lys 
        115                 120                 125             


Asn Asn Ala Glu Cys Val Arg Ala Leu Leu Glu Ser Gly Ala Ser Val 
    130                 135                 140                 


Asn Ala Leu Asp Tyr Asn Asn Asp Thr Pro Leu Ser Trp Ala Ala Met 
145                 150                 155                 160 


Lys Gly Asn Leu Glu Ser Val Ser Ile Leu Leu Asp Tyr Gly Ala Glu 
                165                 170                 175     


Val Arg Val Ile Asn Leu Ile Gly Gln Thr Pro Ile Ser Arg Leu Val 
            180                 185                 190         


Ala Leu Leu Val Arg Gly Leu Gly Thr Glu Lys Glu Asp Ser Cys Phe 
        195                 200                 205             


Glu Leu Leu His Arg Ala Val Gly His Phe Glu Leu Arg Lys Asn Gly 
    210                 215                 220                 


Thr Met Pro Arg Glu Val Ala Arg Asp Pro Gln Leu Cys Glu Lys Leu 
225                 230                 235                 240 


Thr Val Leu Cys Ser Ala Pro Gly Thr Leu Lys Thr Leu Ala Arg Tyr 
                245                 250                 255     


Ala Val Arg Arg Ser Leu Gly Leu Gln Tyr Leu Pro Asp Ala Val Lys 
            260                 265                 270         


Gly Leu Pro Leu Pro Ala Ser Leu Lys Glu Tyr Leu Leu Leu Leu Glu 
        275                 280                 285             


<210> 8719
<211> 182
<212> PRT
<213> Homo sapiens

<400> 8719
Met Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Thr Phe His Gln Ala Asn Thr Glu Gln Pro Lys Leu Ser Arg Asp 
            20                  25                  30          


Glu Gln Arg Gly Arg Gly Ala Leu Leu Gln Asp Ile Cys Lys Gly Thr 
        35                  40                  45              


Lys Leu Lys Lys Val Thr Asn Ile Asn Asp Arg Ser Ala Pro Ile Leu 
    50                  55                  60                  


Glu Thr Pro Pro Pro Pro Pro Pro Val Ile Arg Asn Gly Ala Arg Asp 
65                  70                  75                  80  


Ala Pro Pro Pro Pro Pro Pro Tyr Arg Met His Gly Ser Glu Pro Pro 
                85                  90                  95      


Ser Arg Gly Lys Pro Pro Pro Pro Pro Ser Arg Thr Pro Ala Gly Pro 
            100                 105                 110         


Pro Pro Pro Pro Pro Pro Pro Leu Arg Asn Gly His Arg Asp Ser Ile 
        115                 120                 125             


Thr Thr Val Arg Ser Phe Leu Asp Asp Phe Glu Ser Lys Tyr Ser Phe 
    130                 135                 140                 


His Pro Val Glu Asp Phe Pro Ala Pro Glu Glu Tyr Lys His Phe Gln 
145                 150                 155                 160 


Arg Ile Tyr Pro Ser Lys Thr Asn Arg Ala Ala Arg Gly Ala Pro Pro 
                165                 170                 175     


Leu Pro Pro Ile Leu Arg 
            180         


<210> 8720
<211> 332
<212> PRT
<213> Homo sapiens

<400> 8720
Met Asp Gln Pro Ala Gly Leu Gln Val Asp Tyr Val Phe Arg Gly Val 
1               5                   10                  15      


Glu His Ala Val Arg Val Met Val Ser Gly Gln Val Leu Glu Leu Glu 
            20                  25                  30          


Val Glu Asp Arg Met Thr Ala Asp Gln Trp Arg Gly Glu Phe Asp Ala 
        35                  40                  45              


Gly Phe Ile Glu Asp Leu Thr His Lys Thr Gly Asn Phe Lys Gln Phe 
    50                  55                  60                  


Asn Ile Phe Cys His Met Leu Glu Ser Ala Leu Thr Gln Ser Ser Glu 
65                  70                  75                  80  


Ser Val Thr Leu Asp Leu Leu Thr Tyr Thr Asp Leu Glu Ser Leu Arg 
                85                  90                  95      


Asn Arg Lys Met Gly Gly Arg Pro Gly Ser Leu Ala Pro Arg Ser Ala 
            100                 105                 110         


Gln Leu Asn Ser Lys Arg Tyr Leu Ile Leu Ile Tyr Ser Val Glu Phe 
        115                 120                 125             


Asp Arg Ile His Tyr Pro Leu Pro Leu Pro Tyr Gln Gly Lys Pro Asp 
    130                 135                 140                 


Pro Val Val Leu Gln Gly Ile Ile Arg Ser Leu Lys Glu Glu Leu Gly 
145                 150                 155                 160 


Arg Leu Gln Gly Leu Asp Gly Gln Asn Thr Arg Asp Thr Arg Glu Asn 
                165                 170                 175     


Glu Ile Trp His Leu Arg Glu Gln Gln Gln Gln Arg Asn Arg Leu Gly 
            180                 185                 190         


Ser Gly Gly Ser Gly Asp Gly Pro Ser Val Ser Trp Ser Arg Gln Thr 
        195                 200                 205             


Gln Pro Pro Ala Ala Leu Thr Gly Arg Gly Asp Ala Pro Asn Arg Ser 
    210                 215                 220                 


Arg Asn Arg Ser Ser Ser Val Asp Ser Phe Arg Ser Arg Cys Ser Ser 
225                 230                 235                 240 


Ala Ser Ser Cys Ser Asp Leu Glu Asp Phe Ser Glu Ser Leu Ser Arg 
                245                 250                 255     


Gly Gly His Arg Arg Arg Gly Lys Pro Pro Ser Pro Thr Pro Trp Ser 
            260                 265                 270         


Gly Ser Asn Met Lys Ser Pro Pro Val Glu Arg Ser His His Gln Lys 
        275                 280                 285             


Ser Leu Ala Asn Ser Gly Gly Trp Val Pro Ile Lys Glu Tyr Ser Ser 
    290                 295                 300                 


Glu His Gln Ala Ala Asp Met Ala Glu Ile Asp Ala Arg Leu Lys Ala 
305                 310                 315                 320 


Leu Gln Glu Tyr Met Asn Arg Leu Asp Met Arg Ser 
                325                 330         


<210> 8721
<211> 171
<212> PRT
<213> Homo sapiens

<400> 8721
Met Ser Ser Lys Arg Thr Lys Thr Lys Thr Lys Lys Arg Pro Gln Arg 
1               5                   10                  15      


Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 
            20                  25                  30          


Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 
        35                  40                  45              


Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro 
    50                  55                  60                  


Thr Asp Glu Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro Ile 
65                  70                  75                  80  


Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 
                85                  90                  95      


Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 
            100                 105                 110         


Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr 
        115                 120                 125             


Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu 
    130                 135                 140                 


Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg 
145                 150                 155                 160 


Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                165                 170     


<210> 8722
<211> 796
<212> PRT
<213> Homo sapiens

<400> 8722
Met Ser Leu Asp Asp Asn Leu Ser Gly Thr Ser Gly Met Glu Val Asp 
1               5                   10                  15      


Asp Arg Val Ser Ala Leu Glu Gln Arg Leu Gln Leu Gln Glu Asp Glu 
            20                  25                  30          


Leu Ala Val Leu Lys Ala Ala Leu Ala Asp Ala Leu Arg Arg Leu Arg 
        35                  40                  45              


Ala Cys Glu Glu Gln Gly Ala Ala Leu Arg Ala Arg Gly Thr Pro Lys 
    50                  55                  60                  


Gly Arg Ala Pro Pro Arg Leu Gly Thr Thr Ala Ser Val Cys Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Leu Pro Thr Arg Thr Pro Leu Asn Gly Ser Gly Pro Pro 
                85                  90                  95      


Arg Arg Val Gly Gly Tyr Ala Thr Ser Pro Ser Ser Pro Lys Lys Glu 
            100                 105                 110         


Ala Thr Ser Gly Arg Ser Ser Val Arg Arg Tyr Leu Ser Pro Glu Arg 
        115                 120                 125             


Leu Ala Ser Val Arg Arg Glu Asp Pro Arg Ser Arg Thr Thr Ser Ser 
    130                 135                 140                 


Ser Ser Asn Cys Ser Ala Lys Lys Glu Gly Lys Thr Lys Glu Val Ile 
145                 150                 155                 160 


Phe Ser Val Glu Asp Gly Ser Val Lys Met Phe Leu Arg Gly Arg Pro 
                165                 170                 175     


Val Pro Met Met Ile Pro Asp Glu Leu Ala Pro Thr Tyr Ser Leu Asp 
            180                 185                 190         


Thr Arg Ser Glu Leu Pro Ser Cys Arg Leu Lys Leu Glu Trp Val Tyr 
        195                 200                 205             


Gly Tyr Arg Gly Arg Asp Cys Arg Ala Asn Leu Tyr Leu Leu Pro Thr 
    210                 215                 220                 


Gly Glu Ile Val Tyr Phe Val Ala Ser Val Ala Val Leu Tyr Ser Val 
225                 230                 235                 240 


Glu Glu Gln Arg Gln Arg His Tyr Leu Gly His Asn Asp Asp Ile Lys 
                245                 250                 255     


Cys Leu Ala Ile His Pro Asp Met Val Thr Ile Ala Thr Gly Gln Val 
            260                 265                 270         


Ala Gly Thr Thr Lys Glu Gly Lys Pro Leu Pro Pro His Val Arg Ile 
        275                 280                 285             


Trp Asp Ser Val Ser Leu Ser Thr Leu His Val Leu Gly Leu Gly Val 
    290                 295                 300                 


Phe Asp Arg Ala Val Cys Cys Val Gly Phe Ser Lys Ser Asn Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Cys Ala Val Asp Glu Ser Asn Asp His Met Leu Ser Val 
                325                 330                 335     


Trp Asp Trp Ala Lys Glu Thr Lys Val Val Asp Val Lys Cys Ser Asn 
            340                 345                 350         


Glu Ala Val Leu Val Ala Thr Phe His Pro Thr Asp Pro Thr Val Leu 
        355                 360                 365             


Ile Thr Cys Gly Lys Ser His Ile Tyr Phe Trp Thr Leu Glu Gly Gly 
    370                 375                 380                 


Ser Leu Ser Lys Arg Gln Gly Leu Phe Glu Lys His Glu Lys Pro Lys 
385                 390                 395                 400 


Tyr Val Leu Cys Val Thr Phe Leu Glu Gly Gly Asp Val Val Thr Gly 
                405                 410                 415     


Asp Ser Gly Gly Asn Leu Tyr Val Trp Gly Lys Gly Gly Asn Arg Ile 
            420                 425                 430         


Thr Gln Ala Val Leu Gly Ala His Asp Gly Gly Val Phe Gly Leu Cys 
        435                 440                 445             


Ala Leu Arg Asp Gly Thr Leu Val Ser Gly Gly Gly Arg Asp Arg Arg 
    450                 455                 460                 


Val Val Leu Trp Gly Ser Asp Tyr Ser Lys Leu Gln Glu Val Glu Val 
465                 470                 475                 480 


Pro Glu Asp Phe Gly Pro Val Arg Thr Val Ala Glu Gly His Gly Asp 
                485                 490                 495     


Thr Leu Tyr Val Gly Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val 
            500                 505                 510         


His Thr Gly Phe Ser Leu Leu Val Gln Gly His Val Glu Glu Leu Trp 
        515                 520                 525             


Gly Leu Ala Thr His Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln 
    530                 535                 540                 


Asp Lys Leu Val His Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp 
545                 550                 555                 560 


Ser Arg Ile Ile Glu Asp Pro Ala Arg Ser Ala Gly Phe His Pro Ser 
                565                 570                 575     


Gly Ser Val Leu Ala Val Gly Thr Val Thr Gly Arg Trp Leu Leu Leu 
            580                 585                 590         


Asp Thr Glu Thr His Asp Leu Val Ala Ile His Thr Asp Gly Asn Glu 
        595                 600                 605             


Gln Ile Ser Val Val Ser Phe Ser Pro Asp Gly Ala Tyr Leu Ala Val 
    610                 615                 620                 


Gly Ser His Asp Asn Leu Val Tyr Val Tyr Thr Val Asp Gln Gly Gly 
625                 630                 635                 640 


Arg Lys Val Ser Arg Leu Gly Lys Cys Ser Gly His Ser Ser Phe Ile 
                645                 650                 655     


Thr His Leu Asp Trp Ala Gln Asp Ser Ser Cys Phe Val Thr Asn Ser 
            660                 665                 670         


Gly Asp Tyr Glu Ile Leu Tyr Trp Asp Pro Ala Thr Cys Lys Gln Ile 
        675                 680                 685             


Thr Ser Ala Asp Ala Val Arg Asn Met Glu Trp Ala Thr Ala Thr Cys 
    690                 695                 700                 


Val Leu Gly Phe Gly Val Phe Gly Ile Trp Ser Glu Gly Ala Asp Gly 
705                 710                 715                 720 


Thr Asp Ile Asn Ala Val Ala Arg Ser His Asp Gly Lys Leu Leu Ala 
                725                 730                 735     


Ser Ala Asp Asp Phe Gly Lys Val His Leu Phe Ser Tyr Pro Cys Cys 
            740                 745                 750         


Gln Pro Arg Ala Leu Ser His Lys Tyr Gly Gly His Ser Ser His Val 
        755                 760                 765             


Thr Asn Val Ala Phe Leu Trp Asp Asp Ser Met Ala Leu Thr Thr Gly 
    770                 775                 780                 


Gly Lys Asp Thr Ser Val Leu Gln Trp Arg Val Val 
785                 790                 795     


<210> 8723
<211> 352
<212> PRT
<213> Homo sapiens

<400> 8723
Met Ala Leu Leu Gly Gln Ala Leu Lys Trp Gln Gln His Gln Gly Leu 
1               5                   10                  15      


Leu Pro Pro Gly Met Thr Ile Asp Leu Phe Arg Gly Lys Ala Ala Val 
            20                  25                  30          


Lys Asp Val Glu Glu Glu Lys Phe Pro Thr Gln Leu Ser Arg His Ile 
        35                  40                  45              


Lys Phe Gly Gln Lys Ser His Val Glu Cys Ala Arg Phe Ser Pro Asp 
    50                  55                  60                  


Gly Gln Tyr Leu Val Thr Gly Ser Val Asp Gly Phe Ile Glu Val Trp 
65                  70                  75                  80  


Asn Phe Thr Thr Gly Lys Ile Arg Lys Asp Leu Lys Tyr Gln Ala Gln 
                85                  90                  95      


Asp Asn Phe Met Met Met Asp Asp Ala Val Leu Cys Met Cys Phe Ser 
            100                 105                 110         


Arg Asp Thr Glu Met Leu Ala Thr Gly Ala Gln Asp Gly Lys Ile Lys 
        115                 120                 125             


Val Trp Lys Ile Gln Ser Gly Gln Cys Leu Arg Arg Phe Glu Arg Ala 
    130                 135                 140                 


His Ser Lys Gly Val Thr Cys Leu Ser Phe Ser Lys Asp Ser Ser Gln 
145                 150                 155                 160 


Ile Leu Ser Ala Ser Phe Asp Gln Thr Ile Arg Ile His Gly Leu Lys 
                165                 170                 175     


Ser Gly Lys Thr Leu Lys Glu Phe Arg Gly His Ser Ser Phe Val Asn 
            180                 185                 190         


Glu Ala Thr Phe Thr Gln Asp Gly His Tyr Ile Ile Ser Ala Ser Ser 
        195                 200                 205             


Asp Gly Thr Val Lys Ile Trp Asn Met Lys Thr Thr Glu Cys Ser Asn 
    210                 215                 220                 


Thr Phe Lys Ser Leu Gly Ser Thr Ala Gly Thr Asp Ile Thr Val Asn 
225                 230                 235                 240 


Ser Val Ile Leu Leu Pro Lys Asn Pro Glu His Phe Val Val Cys Asn 
                245                 250                 255     


Arg Ser Asn Thr Val Val Ile Met Asn Met Gln Gly Gln Ile Val Arg 
            260                 265                 270         


Ser Phe Ser Ser Gly Lys Arg Glu Gly Gly Asp Phe Val Cys Cys Ala 
        275                 280                 285             


Leu Ser Pro Arg Gly Glu Trp Ile Tyr Cys Val Gly Glu Asp Phe Val 
    290                 295                 300                 


Leu Tyr Cys Phe Ser Thr Val Thr Gly Lys Leu Glu Arg Thr Leu Thr 
305                 310                 315                 320 


Val His Glu Lys Asp Val Ile Gly Ile Ala His His Pro His Gln Asn 
                325                 330                 335     


Leu Ile Ala Thr Tyr Ser Glu Asp Gly Leu Leu Lys Leu Trp Lys Pro 
            340                 345                 350         


<210> 8724
<211> 316
<212> PRT
<213> Homo sapiens

<400> 8724
Met Gln Ser Trp Val Leu Ile Ser Lys Glu Leu Ile Ser Leu Leu His 
1               5                   10                  15      


Leu Ser Leu Leu His Leu Glu Glu Asp Lys Thr Thr Val Ser Gln Glu 
            20                  25                  30          


Ser Arg Arg Ala Glu Thr Leu Val Cys Cys Cys Phe Asp Leu Leu Lys 
        35                  40                  45              


Lys Leu Arg Ala Lys Leu Gln Ser Leu Lys Ala Glu Arg Glu Glu Ala 
    50                  55                  60                  


Arg His Arg Glu Glu Met Ala Leu Arg Gly Lys Asp Ala Ala Glu Ile 
65                  70                  75                  80  


Val Leu Glu Ala Phe Cys Ala His Ala Ser Gln Arg Ile Ser Gln Leu 
                85                  90                  95      


Glu Gln Asp Leu Ala Ser Met Arg Glu Phe Arg Gly Leu Leu Lys Asp 
            100                 105                 110         


Ala Gln Thr Gln Leu Val Gly Leu His Ala Lys Gln Glu Glu Leu Val 
        115                 120                 125             


Gln Gln Thr Val Ser Leu Thr Ser Thr Leu Gln Gln Asp Trp Arg Ser 
    130                 135                 140                 


Met Gln Leu Asp Tyr Thr Thr Trp Thr Ala Leu Leu Ser Arg Ser Arg 
145                 150                 155                 160 


Gln Leu Thr Glu Lys Leu Thr Val Lys Ser Gln Gln Ala Leu Gln Glu 
                165                 170                 175     


Arg Asp Val Ala Ile Glu Glu Lys Gln Glu Val Ser Arg Val Leu Glu 
            180                 185                 190         


Gln Val Ser Ala Gln Leu Glu Glu Cys Lys Gly Gln Thr Glu Gln Leu 
        195                 200                 205             


Glu Leu Glu Asn Ser Arg Leu Ala Thr Asp Leu Arg Ala Gln Leu Gln 
    210                 215                 220                 


Ile Leu Ala Asn Met Asp Ser Gln Leu Lys Glu Leu Gln Ser Gln His 
225                 230                 235                 240 


Thr His Cys Ala Gln Asp Leu Ala Met Lys Asp Glu Leu Leu Cys Gln 
                245                 250                 255     


Leu Thr Gln Ser Asn Glu Glu Gln Ala Ala Gln Trp Gln Lys Glu Glu 
            260                 265                 270         


Met Ala Leu Lys His Met Gln Ala Glu Leu Gln Gln Gln Gln Ala Val 
        275                 280                 285             


Leu Ala Lys Glu Val Arg Asp Leu Lys Glu Thr Leu Glu Phe Ala Asp 
    290                 295                 300                 


Gln Glu Asn Gln Val Ala His Leu Glu Leu Ala Trp 
305                 310                 315     


<210> 8725
<211> 198
<212> PRT
<213> Homo sapiens

<400> 8725
Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210> 8726
<211> 196
<212> PRT
<213> Homo sapiens

<400> 8726
Met Val Pro Arg Pro Trp Ser Gly Ser Pro Gly Pro Gly Glu Cys Leu 
1               5                   10                  15      


His Ser Leu Leu Ser Glu Arg Leu Trp Ile Cys Arg Asp Ile Ser Ala 
            20                  25                  30          


Gln Arg Arg Ser Ala Pro Gly Ser Pro Arg Pro Ser Asp Cys Gln Gln 
        35                  40                  45              


Leu Ser Phe Leu Pro Gly Asn Gln Pro Thr Phe Leu Cys Leu Gln Ala 
    50                  55                  60                  


Leu Ala Ala Leu Val Pro Gly Val Thr Gln Val Asp Asn Lys Ser Gly 
65                  70                  75                  80  


Phe Leu Gln Lys Arg Pro His Arg Gln His Pro Gly Ile Leu Lys Leu 
                85                  90                  95      


Pro His Val Arg Leu Pro Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu 
            100                 105                 110         


Leu Leu Gly Ser Ala Gly Pro Thr Met Glu Asn Gln Val Gln Thr Leu 
        115                 120                 125             


Thr Ser Tyr Leu Trp Ser Arg His Leu Pro Val Glu Pro Glu Glu Leu 
    130                 135                 140                 


Gln Arg Arg Ala Arg His Leu Glu Lys Lys Phe Leu Glu Asn Pro Gly 
145                 150                 155                 160 


Pro Asp Phe Gln Ser Leu Phe Ser Pro Gln Thr Tyr Leu Arg Gln Arg 
                165                 170                 175     


Arg Asn Phe Val Glu Gln Cys Tyr Thr His Tyr Val Lys Leu Pro Thr 
            180                 185                 190         


Ile Gly Lys Asn 
        195     


<210> 8727
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8727
Met Pro Asp Val Val Gln Thr Arg Gln Gln Ala Tyr Arg Asp Lys Leu 
1               5                   10                  15      


Ala Gln Gln Gln Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser 
            20                  25                  30          


Gln Gln Gly Ser Ala Lys Asn Gly Glu Asn Thr Ala Asn Gly Glu Glu 
        35                  40                  45              


Asn Gly Ala His Thr Ile Ala Arg Ile Trp Asn Leu Ser Glu Asn Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Gln Leu Val Leu Arg His Cys Ile Arg Glu Gly 
65                  70                  75                  80  


Gly Gln Asp Val Pro Ser Asn Lys Asp Val Thr Ser Leu Asp Trp Asn 
                85                  90                  95      


Ser Glu Gly Thr Leu Leu Ala Thr Gly Ser Tyr Asp Gly Phe Ala Arg 
            100                 105                 110         


Ile Trp Thr Lys Asp Gly Asn Leu Ala Ser Thr Leu Gly Gln His Lys 
        115                 120                 125             


Gly Pro Ile Phe Ala Leu Lys Trp Asn Lys Lys Gly Asn Phe Ile Leu 
    130                 135                 140                 


Ser Ala Gly Val Asp Lys Thr Thr Ile Ile Trp Asp Ala His Thr Gly 
145                 150                 155                 160 


Glu Ala Lys Gln Gln Phe Pro Phe His Ser Ala Pro Ala Leu Asp Val 
                165                 170                 175     


Asp Trp Gln Ser Asn Asn Thr Phe Ala Ser Cys Ser Thr Asp Met Cys 
            180                 185                 190         


Ile His Val Cys Lys Leu Gly Gln Asp Arg Pro Ile Lys Thr Phe Gln 
        195                 200                 205             


Gly His Thr Asn Glu Val Asn Ala Ile Lys Trp Asp Pro Thr Gly Asn 
    210                 215                 220                 


Leu Leu Ala Ser Cys Ser Asp Asp Met Thr Leu Lys Ile Trp Ser Met 
225                 230                 235                 240 


Lys Gln Asp Asn Cys Val His Asp Leu Gln Ala His Asn Lys Glu Ile 
                245                 250                 255     


Tyr Thr Ile Lys Trp Ser Pro Thr Gly Pro Gly Thr Asn Asn Pro Asn 
            260                 265                 270         


Ala Asn Leu Met Leu Ala Ser Ala Ser Phe Asp Ser Thr Val Arg Leu 
        275                 280                 285             


Trp Asp Val Asp Arg Gly Ile Cys Ile His Thr Leu Thr Lys His Gln 
    290                 295                 300                 


Glu Pro Val Tyr Ser Val Ala Phe Ser Pro Asp Gly Arg Tyr Leu Ala 
305                 310                 315                 320 


Ser Gly Ser Phe Asp Lys Cys Val His Ile Trp Asn Thr Gln Thr Gly 
                325                 330                 335     


Ala Leu Val His Ser Tyr Arg Gly Thr Gly Gly Ile Phe Glu Val Cys 
            340                 345                 350         


Trp Asn Ala Ala Gly Asp Lys Val Gly Ala Ser Ala Ser Asp Gly Ser 
        355                 360                 365             


Val Cys Val Leu Asp Leu Arg Lys 
    370                 375     


<210> 8728
<211> 371
<212> PRT
<213> Homo sapiens

<400> 8728
Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln 
1               5                   10                  15      


Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly 
            20                  25                  30          


Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu 
        35                  40                  45              


Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser 
65                  70                  75                  80  


Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu 
                85                  90                  95      


Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg 
            100                 105                 110         


Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln 
        115                 120                 125             


Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu 
    130                 135                 140                 


Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu 
145                 150                 155                 160 


Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr 
                165                 170                 175     


Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu 
            180                 185                 190         


Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln 
        195                 200                 205             


Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met 
    210                 215                 220                 


Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met 
                245                 250                 255     


Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys 
            260                 265                 270         


Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys 
        275                 280                 285             


Asp Lys Glu Thr Gly Gly Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala 
    290                 295                 300                 


Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys 
                325                 330                 335     


Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Lys 
            340                 345                 350         


Ile Lys Arg Lys Ala Phe Trp Lys Ser Ala Gly Ser Cys Leu Val Ile 
        355                 360                 365             


Leu Val Asp 
    370     


<210> 8729
<211> 168
<212> PRT
<213> Homo sapiens

<400> 8729
His Lys Leu Gln Ser Gly Ile Gly Arg Leu Ile Leu Lys Glu Glu Met 
1               5                   10                  15      


Lys Ala Arg Ser Ser Ser Tyr Ala Asp Pro Trp Thr Pro Pro Arg Ser 
            20                  25                  30          


Ser Thr Ser Ser Arg Glu Ala Leu His Thr Ala Gly Tyr Glu Met Ser 
        35                  40                  45              


Leu Asn Gly Ser Pro Arg Ser His Tyr Leu Ala Asp Ser Asp Pro Leu 
    50                  55                  60                  


Ile Ser Lys Ser Ala Ser Leu Pro Ala Tyr Arg Arg Asn Gly Leu His 
65                  70                  75                  80  


Arg Thr Pro Ser Ala Asp Leu Phe His Tyr Asp Ser Met Asn Ala Val 
                85                  90                  95      


Asn Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr Glu Leu Leu Leu 
            100                 105                 110         


Val Thr Thr Arg Gly Arg Asn Arg Leu Pro Lys Asp Val Asp Arg Thr 
        115                 120                 125             


Arg Leu Glu Arg His Leu Ser Gln Glu Glu Phe Tyr Gln Val Phe Gly 
    130                 135                 140                 


Met Thr Ile Ser Glu Phe Asp Arg Leu Ala Leu Trp Lys Arg Asn Glu 
145                 150                 155                 160 


Leu Lys Lys Gln Ala Arg Leu Phe 
                165             


<210> 8730
<211> 589
<212> PRT
<213> Homo sapiens

<400> 8730
Met Ser Val Ser Val His Glu Thr Arg Lys Ser Arg Ser Ser Thr Gly 
1               5                   10                  15      


Ser Met Asn Val Thr Leu Phe His Lys Ala Ser His Pro Asp Cys Val 
            20                  25                  30          


Leu Ala His Leu Asn Thr Leu Arg Lys His Cys Met Phe Thr Asp Val 
        35                  40                  45              


Thr Leu Trp Ala Gly Asp Arg Ala Phe Pro Cys His Arg Ala Val Leu 
    50                  55                  60                  


Ala Ala Ser Ser Arg Tyr Phe Glu Ala Met Phe Ser His Gly Leu Arg 
65                  70                  75                  80  


Glu Ser Arg Asp Asp Thr Val Asn Phe Gln Asp Asn Leu His Pro Glu 
                85                  90                  95      


Val Leu Glu Leu Leu Leu Asp Phe Ala Tyr Ser Ser Arg Ile Ala Ile 
            100                 105                 110         


Asn Glu Glu Asn Ala Glu Ser Leu Leu Glu Ala Gly Asp Met Leu Gln 
        115                 120                 125             


Phe His Asp Val Arg Asp Ala Ala Ala Glu Phe Leu Glu Lys Asn Leu 
    130                 135                 140                 


Phe Pro Ser Asn Cys Leu Gly Met Met Leu Leu Ser Asp Ala His Gln 
145                 150                 155                 160 


Cys Arg Arg Leu Tyr Glu Phe Ser Trp Arg Met Cys Leu Val His Phe 
                165                 170                 175     


Glu Thr Val Arg Gln Ser Glu Asp Phe Asn Ser Leu Ser Lys Asp Thr 
            180                 185                 190         


Leu Leu Asp Leu Ile Ser Ser Asp Glu Leu Glu Thr Glu Asp Glu Arg 
        195                 200                 205             


Val Val Phe Glu Ala Ile Leu Gln Trp Val Lys His Asp Leu Glu Pro 
    210                 215                 220                 


Arg Lys Val His Leu Pro Glu Leu Leu Arg Ser Val Arg Leu Ala Leu 
225                 230                 235                 240 


Leu Pro Ser Asp Cys Leu Gln Glu Ala Val Ser Ser Glu Ala Leu Leu 
                245                 250                 255     


Met Ala Asp Glu Arg Thr Lys Leu Ile Met Asp Glu Ala Leu Arg Cys 
            260                 265                 270         


Lys Thr Arg Ile Leu Gln Asn Asp Gly Val Val Thr Ser Pro Cys Ala 
        275                 280                 285             


Arg Pro Arg Lys Ala Gly His Thr Leu Leu Ile Leu Gly Gly Gln Thr 
    290                 295                 300                 


Phe Met Cys Asp Lys Ile Tyr Gln Val Asp His Lys Ala Lys Glu Ile 
305                 310                 315                 320 


Ile Pro Lys Ala Asp Leu Pro Ser Pro Arg Lys Glu Phe Ser Ala Ser 
                325                 330                 335     


Ala Ile Gly Cys Lys Val Tyr Val Thr Gly Gly Arg Gly Ser Glu Asn 
            340                 345                 350         


Gly Val Ser Lys Asp Val Trp Val Tyr Asp Thr Val His Glu Glu Trp 
        355                 360                 365             


Ser Lys Ala Ala Pro Met Leu Ile Ala Arg Phe Gly His Gly Ser Ala 
    370                 375                 380                 


Glu Leu Glu Asn Cys Leu Tyr Val Val Gly Gly His Thr Ser Leu Ala 
385                 390                 395                 400 


Gly Val Phe Pro Ala Ser Pro Ser Val Ser Leu Lys Gln Val Glu Lys 
                405                 410                 415     


Tyr Asp Pro Gly Ala Asn Lys Trp Met Met Val Ala Pro Leu Arg Asp 
            420                 425                 430         


Gly Val Ser Asn Ala Ala Val Val Ser Ala Lys Leu Lys Leu Phe Val 
        435                 440                 445             


Phe Gly Gly Thr Ser Ile His Arg Asp Met Val Ser Lys Val Gln Cys 
    450                 455                 460                 


Tyr Asp Pro Ser Glu Asn Arg Trp Thr Ile Lys Ala Glu Cys Pro Gln 
465                 470                 475                 480 


Pro Trp Arg Tyr Thr Ala Ala Ala Val Leu Gly Ser Gln Ile Phe Ile 
                485                 490                 495     


Met Gly Gly Asp Thr Glu Phe Thr Ala Ala Ser Ala Tyr Arg Phe Asp 
            500                 505                 510         


Cys Glu Thr Asn Gln Trp Thr Arg Ile Gly Asp Met Thr Ala Lys Arg 
        515                 520                 525             


Met Ser Cys His Ala Leu Ala Ser Gly Asn Lys Leu Tyr Val Val Gly 
    530                 535                 540                 


Gly Tyr Phe Gly Thr Gln Arg Cys Lys Thr Leu Asp Cys Tyr Asp Pro 
545                 550                 555                 560 


Thr Ser Asp Thr Trp Asn Cys Ile Thr Thr Val Pro Tyr Ser Leu Ile 
                565                 570                 575     


Pro Thr Ala Phe Val Ser Thr Trp Lys His Leu Pro Ala 
            580                 585                 


<210> 8731
<211> 428
<212> PRT
<213> Homo sapiens

<400> 8731
Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95      


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110         


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125             


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140                 


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175     


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190         


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205             


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220                 


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240 


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255     


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270         


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285             


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300                 


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320 


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu His 
                325                 330                 335     


Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met Val Glu 
            340                 345                 350         


Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu Glu Glu 
        355                 360                 365             


Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu Ser Ile 
    370                 375                 380                 


Thr Lys Gly Asp Leu Glu Gln Lys Ser Gln Ile Ser Glu Asp Pro Glu 
385                 390                 395                 400 


Asn Val Arg Gly His Leu Thr Val Trp Ile Phe Pro Leu Leu Thr Lys 
                405                 410                 415     


Ile Asp His Arg Leu Lys Cys Leu Leu Ile Tyr Ser 
            420                 425             


<210> 8732
<211> 1160
<212> PRT
<213> Homo sapiens

<400> 8732
Met Val Val Thr Leu Gly Pro Gly Pro Asp Cys Leu Ile Leu Glu Ala 
1               5                   10                  15      


Ser Arg Gln Pro Gln Leu Val Pro Lys Pro Glu Arg Met Ala Ser Asp 
            20                  25                  30          


Gly Ala Ser Ala Leu Pro Gly Pro Asp Met Ser Met Lys Pro Ser Ala 
        35                  40                  45              


Ala Pro Ser Pro Ser Pro Ala Leu Pro Phe Leu Pro Pro Thr Ser Asp 
    50                  55                  60                  


Pro Pro Asp His Pro Pro Arg Glu Pro Pro Pro Gln Pro Ile Met Pro 
65                  70                  75                  80  


Ser Val Phe Ser Pro Asp Asn Pro Leu Met Leu Ser Ala Phe Pro Ser 
                85                  90                  95      


Ser Leu Leu Val Thr Gly Asp Gly Gly Pro Cys Leu Ser Gly Ala Gly 
            100                 105                 110         


Ala Gly Lys Val Ile Val Lys Val Lys Thr Glu Gly Gly Ser Ala Glu 
        115                 120                 125             


Pro Ser Gln Thr Gln Asn Phe Ile Leu Thr Gln Thr Ala Leu Asn Ser 
    130                 135                 140                 


Thr Ala Pro Gly Thr Pro Cys Gly Gly Leu Glu Gly Pro Ala Pro Pro 
145                 150                 155                 160 


Phe Val Thr Ala Ser Asn Val Lys Thr Ile Leu Pro Ser Lys Ala Val 
                165                 170                 175     


Gly Val Ser Gln Glu Gly Pro Pro Gly Leu Pro Pro Gln Pro Pro Pro 
            180                 185                 190         


Pro Val Ala Gln Leu Val Pro Ile Val Pro Leu Glu Lys Ala Trp Pro 
        195                 200                 205             


Gly Pro His Gly Thr Thr Gly Glu Gly Gly Pro Val Ala Thr Leu Ser 
    210                 215                 220                 


Lys Pro Ser Leu Gly Asp Arg Ser Lys Ile Ser Lys Asp Val Tyr Glu 
225                 230                 235                 240 


Asn Phe Arg Gln Trp Gln Arg Tyr Lys Ala Leu Ala Arg Arg His Leu 
                245                 250                 255     


Ser Gln Ser Pro Asp Thr Glu Ala Leu Ser Cys Phe Leu Ile Pro Val 
            260                 265                 270         


Leu Arg Ser Leu Ala Arg Leu Lys Pro Thr Met Thr Leu Glu Glu Gly 
        275                 280                 285             


Leu Pro Leu Ala Val Gln Glu Trp Glu His Thr Ser Asn Phe Asp Arg 
    290                 295                 300                 


Met Ile Phe Tyr Glu Met Ala Glu Arg Phe Met Glu Phe Glu Ala Glu 
305                 310                 315                 320 


Glu Met Gln Ile Gln Asn Thr Gln Leu Met Asn Gly Ser Gln Gly Leu 
                325                 330                 335     


Ser Pro Ala Thr Pro Leu Lys Leu Asp Pro Leu Gly Pro Leu Ala Ser 
            340                 345                 350         


Glu Val Cys Gln Gln Pro Val Tyr Ile Pro Lys Lys Ala Ala Ser Lys 
        355                 360                 365             


Thr Arg Ala Pro Arg Arg Arg Gln Arg Lys Ala Gln Arg Pro Pro Ala 
    370                 375                 380                 


Pro Glu Ala Pro Lys Glu Ile Pro Pro Glu Ala Val Lys Glu Tyr Val 
385                 390                 395                 400 


Asp Ile Met Glu Trp Leu Val Gly Thr His Leu Ala Thr Gly Glu Ser 
                405                 410                 415     


Asp Gly Lys Gln Glu Glu Glu Gly Gln Gln Gln Glu Glu Glu Gly Met 
            420                 425                 430         


Tyr Pro Asp Pro Gly Leu Leu Ser Tyr Ile Asn Glu Leu Cys Ser Gln 
        435                 440                 445             


Lys Val Phe Val Ser Lys Val Glu Ala Val Ile His Pro Gln Phe Leu 
    450                 455                 460                 


Ala Asp Leu Leu Ser Pro Glu Lys Gln Arg Asp Pro Leu Ala Leu Ile 
465                 470                 475                 480 


Glu Glu Leu Glu Gln Glu Glu Gly Leu Thr Leu Ala Gln Leu Val Gln 
                485                 490                 495     


Lys Arg Leu Met Ala Leu Glu Glu Glu Glu Asp Ala Glu Ala Pro Pro 
            500                 505                 510         


Ser Phe Ser Gly Ala Gln Leu Asp Ser Ser Pro Ser Gly Ser Val Glu 
        515                 520                 525             


Asp Glu Asp Gly Asp Gly Arg Leu Arg Pro Ser Pro Gly Leu Gln Gly 
    530                 535                 540                 


Ala Gly Gly Ala Ala Cys Leu Gly Lys Val Ser Ser Ser Gly Lys Arg 
545                 550                 555                 560 


Ala Arg Glu Val His Gly Gly Gln Glu Gln Ala Leu Asp Ser Pro Arg 
                565                 570                 575     


Gly Met His Arg Asp Gly Asn Thr Leu Pro Ser Pro Ser Ser Trp Asp 
            580                 585                 590         


Leu Gln Pro Glu Leu Ala Ala Pro Gln Gly Thr Pro Gly Pro Leu Gly 
        595                 600                 605             


Val Glu Arg Arg Gly Ser Gly Lys Val Ile Asn Gln Val Ser Leu His 
    610                 615                 620                 


Gln Asp Gly His Leu Gly Gly Ala Gly Pro Pro Gly His Cys Leu Val 
625                 630                 635                 640 


Ala Asp Arg Thr Ser Glu Ala Leu Pro Leu Cys Trp Gln Gly Gly Phe 
                645                 650                 655     


Gln Pro Glu Ser Thr Pro Ser Leu Asp Ala Gly Leu Ala Glu Leu Ala 
            660                 665                 670         


Pro Leu Gln Gly Gln Gly Leu Glu Lys Gln Val Leu Gly Leu Gln Lys 
        675                 680                 685             


Gly Gln Gln Thr Gly Gly Arg Gly Val Leu Pro Gln Gly Lys Glu Pro 
    690                 695                 700                 


Leu Ala Val Pro Trp Glu Gly Ser Ser Gly Ala Met Trp Gly Asp Asp 
705                 710                 715                 720 


Arg Gly Thr Pro Met Ala Gln Ser Tyr Asp Gln Asn Pro Ser Pro Arg 
                725                 730                 735     


Ala Ala Gly Glu Arg Asp Asp Val Cys Leu Ser Pro Gly Val Trp Leu 
            740                 745                 750         


Ser Ser Glu Met Asp Ala Val Gly Leu Glu Leu Pro Val Gln Ile Glu 
        755                 760                 765             


Glu Val Ile Glu Ser Phe Gln Val Glu Lys Cys Val Thr Glu Tyr Gln 
    770                 775                 780                 


Glu Gly Cys Gln Gly Leu Gly Ser Arg Gly Asn Ile Ser Leu Gly Pro 
785                 790                 795                 800 


Gly Glu Thr Leu Val Pro Gly Asp Thr Glu Ser Ser Val Ile Pro Cys 
                805                 810                 815     


Gly Gly Thr Val Ala Ala Ala Ala Leu Glu Lys Arg Asn Tyr Cys Ser 
            820                 825                 830         


Leu Pro Gly Pro Leu Arg Ala Asn Ser Pro Pro Leu Arg Ser Lys Glu 
        835                 840                 845             


Asn Gln Glu Gln Ser Cys Glu Thr Val Gly His Pro Ser Asp Leu Trp 
    850                 855                 860                 


Ala Glu Gly Cys Phe Pro Leu Leu Glu Ser Gly Asp Ser Thr Leu Gly 
865                 870                 875                 880 


Ser Ser Lys Glu Thr Leu Pro Pro Thr Cys Gln Gly Asn Leu Leu Ile 
                885                 890                 895     


Met Gly Thr Glu Asp Ala Ser Ser Leu Pro Glu Ala Ser Gln Glu Ala 
            900                 905                 910         


Gly Ser Arg Gly Asn Ser Phe Ser Pro Leu Leu Glu Thr Ile Glu Pro 
        915                 920                 925             


Val Asn Ile Leu Asp Val Lys Asp Asp Cys Gly Leu Gln Leu Arg Val 
    930                 935                 940                 


Ser Glu Asp Thr Cys Pro Leu Asn Val His Ser Tyr Asp Pro Gln Gly 
945                 950                 955                 960 


Glu Gly Arg Val Asp Pro Asp Leu Ser Lys Pro Lys Asn Leu Ala Pro 
                965                 970                 975     


Leu Gln Glu Ser Gln Glu Ser Tyr Thr Thr Gly Thr Pro Lys Ala Thr 
            980                 985                 990         


Ser Ser His Gln Gly Leu Gly Ser  Thr Leu Pro Arg Arg  Gly Thr Arg 
        995                 1000                 1005             


Asn Ala  Ile Val Pro Arg Glu  Thr Ser Val Ser Lys  Thr His Arg 
    1010                 1015                 1020             


Ser Ala  Asp Arg Ala Lys Gly  Lys Glu Lys Lys Lys  Lys Glu Ala 
    1025                 1030                 1035             


Glu Glu  Glu Asp Glu Glu Leu  Ser Asn Phe Ala Tyr  Leu Leu Ala 
    1040                 1045                 1050             


Ser Lys  Leu Ser Leu Ser Pro  Arg Glu His Pro Leu  Ser Pro His 
    1055                 1060                 1065             


His Ala  Ser Gly Gly Gln Gly  Ser Gln Arg Ala Ser  His Leu Leu 
    1070                 1075                 1080             


Pro Ala  Gly Ala Lys Gly Pro  Ser Lys Leu Pro Tyr  Pro Val Ala 
    1085                 1090                 1095             


Lys Ser  Gly Lys Arg Ala Leu  Ala Gly Gly Pro Ala  Pro Thr Glu 
    1100                 1105                 1110             


Lys Thr  Pro His Ser Gly Ala  Gln Leu Gly Val Pro  Arg Glu Lys 
    1115                 1120                 1125             


Pro Leu  Ala Leu Gly Val Val  Arg Pro Ser Gln Pro  Arg Lys Arg 
    1130                 1135                 1140             


Arg Cys  Asp Ser Phe Val Thr  Gly Arg Arg Lys Lys  Arg Arg Arg 
    1145                 1150                 1155             


Ser Gln  
    1160 


<210> 8733
<211> 515
<212> PRT
<213> Homo sapiens

<400> 8733
Leu Asn Ser Gln Cys Arg Asn Lys Asn Pro Phe Ala Ala Gly Pro Arg 
1               5                   10                  15      


Pro Pro His His Gln Phe Phe Gln Arg Pro Gln Ile Gln Pro Pro Arg 
            20                  25                  30          


Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg Pro Gly Ala Gln Thr 
        35                  40                  45              


Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile Met Met Val Asn His 
    50                  55                  60                  


Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro Gln Tyr Cys Ile Pro 
65                  70                  75                  80  


Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly Pro Pro Gln Gln Tyr 
                85                  90                  95      


Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr Pro Gly Pro Gly Pro 
            100                 105                 110         


Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe Tyr Pro Ser Gln Pro 
        115                 120                 125             


Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr Gln Gln Gln Pro Pro 
    130                 135                 140                 


Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile Arg Asp Pro Asn Gln 
145                 150                 155                 160 


Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser Gly Gly Gly Ser Arg 
                165                 170                 175     


Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser Thr Pro Thr Pro Pro 
            180                 185                 190         


Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser Pro Val Val Tyr Gly 
        195                 200                 205             


Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr Pro Val Thr Ala Ala 
    210                 215                 220                 


Ser Asp Gln Lys Gln Glu Glu Lys Pro Lys Pro Asp Pro Val Leu Lys 
225                 230                 235                 240 


Ser Pro Ser Pro Val Leu Arg Leu Val Leu Ser Gly Glu Lys Lys Glu 
                245                 250                 255     


Gln Glu Gly Gln Thr Ser Glu Thr Thr Ala Ile Val Ser Ile Ala Glu 
            260                 265                 270         


Leu Pro Leu Pro Pro Ser Pro Thr Thr Val Ser Ser Val Ala Arg Ser 
        275                 280                 285             


Thr Ile Ala Ala Pro Thr Ser Ser Ala Leu Ser Ser Gln Pro Ile Phe 
    290                 295                 300                 


Thr Thr Ala Ile Asp Asp Arg Cys Glu Leu Ser Ser Pro Arg Glu Asp 
305                 310                 315                 320 


Thr Ile Pro Ile Pro Ser Leu Thr Ser Cys Thr Glu Thr Ser Asp Pro 
                325                 330                 335     


Leu Pro Thr Asn Glu Asn Asp Asp Asp Ile Cys Lys Lys Pro Cys Ser 
            340                 345                 350         


Val Ala Pro Asn Asp Ile Pro Leu Val Ser Ser Thr Asn Leu Ile Asn 
        355                 360                 365             


Glu Ile Asn Gly Val Ser Glu Lys Leu Ser Ala Thr Glu Ser Ile Val 
    370                 375                 380                 


Glu Ile Val Lys Gln Glu Val Leu Pro Leu Thr Leu Glu Leu Glu Ile 
385                 390                 395                 400 


Leu Glu Asn Pro Pro Glu Glu Met Lys Leu Glu Cys Ile Pro Ala Pro 
                405                 410                 415     


Ile Thr Pro Ser Thr Val Pro Ser Phe Pro Pro Thr Pro Pro Thr Pro 
            420                 425                 430         


Pro Ala Ser Pro Pro His Thr Pro Val Ile Val Pro Ala Ala Ala Thr 
        435                 440                 445             


Thr Val Ser Ser Pro Ser Ala Ala Ile Thr Val Gln Arg Val Leu Glu 
    450                 455                 460                 


Glu Asp Glu Ser Ile Arg Thr Cys Leu Ser Glu Asp Ala Lys Glu Ile 
465                 470                 475                 480 


Gln Asn Lys Ile Glu Val Glu Ala Asp Gly Gln Thr Glu Glu Ile Leu 
                485                 490                 495     


Asp Ser Gln Asn Leu Asn Ser Arg Arg Ser Pro Val Pro Glu Thr Ser 
            500                 505                 510         


Asn Glu Cys 
        515 


<210> 8734
<211> 67
<212> PRT
<213> Homo sapiens

<400> 8734
Met Ala Leu Leu Ala Glu His Leu Leu Lys Pro Leu Pro Ala Asp Lys 
1               5                   10                  15      


Gln Ile Glu Thr Gly Pro Phe Leu Glu Ala Val Ser His Leu Pro Pro 
            20                  25                  30          


Phe Phe Asp Cys Leu Gly Ser Pro Val Phe Thr Pro Ile Lys Ala Asp 
        35                  40                  45              


Ile Ser Gly Asn Ile Thr Met Arg Lys Leu Arg Leu Arg Gly Val Glu 
    50                  55                  60                  


Gly Leu Ala 
65          


<210> 8735
<211> 805
<212> PRT
<213> Homo sapiens

<400> 8735
Met Met Gln Asn Val His Leu Ala Pro Glu Thr Asp Glu Asp Asp Leu 
1               5                   10                  15      


Tyr Ser Gly Tyr Asn Asp Tyr Asn Pro Ile Tyr Asp Ile Glu Glu Leu 
            20                  25                  30          


Glu Asn Asp Ala Ala Phe Gln Gln Ala Val Arg Thr Ser His Gly Arg 
        35                  40                  45              


Arg Pro Pro Ser Lys Thr Ser Leu Ala Ser Ser Ile Gly Arg Pro Met 
    50                  55                  60                  


Thr Gly Ala Ile Gln Asp Gly Val Thr Arg Pro Met Thr Ala Val Arg 
65                  70                  75                  80  


Ala Ala Gly Phe Thr Lys Ala Ala Leu Arg Gly Ser Ala Phe Asp Pro 
                85                  90                  95      


Leu Ser Gln Ser Arg Gly Pro Ala Ser Pro Leu Glu Ala Lys Lys Lys 
            100                 105                 110         


Asp Ser Pro Glu Glu Lys Ile Lys Gln Leu Glu Lys Glu Val Asn Glu 
        115                 120                 125             


Leu Val Glu Glu Ser Cys Ile Ala Asn Ser Cys Gly Asp Leu Lys Leu 
    130                 135                 140                 


Ala Leu Glu Lys Ala Lys Asp Ala Gly Arg Lys Glu Arg Val Leu Val 
145                 150                 155                 160 


Arg Gln Arg Glu Gln Val Thr Thr Pro Glu Asn Ile Asn Leu Asp Leu 
                165                 170                 175     


Thr Tyr Ser Val Leu Phe Asn Leu Ala Ser Gln Tyr Ser Val Asn Glu 
            180                 185                 190         


Met Tyr Ala Glu Ala Leu Asn Thr Tyr Gln Val Ile Val Lys Asn Lys 
        195                 200                 205             


Met Phe Ser Asn Ala Gly Ile Leu Lys Met Asn Met Gly Asn Ile Tyr 
    210                 215                 220                 


Leu Lys Gln Arg Asn Tyr Ser Lys Ala Ile Lys Phe Tyr Arg Met Ala 
225                 230                 235                 240 


Leu Asp Gln Val Pro Ser Val Asn Lys Gln Met Arg Ile Lys Ile Met 
                245                 250                 255     


Gln Asn Ile Gly Val Thr Phe Ile Gln Ala Gly Gln Tyr Ser Asp Ala 
            260                 265                 270         


Ile Asn Ser Tyr Glu His Ile Met Ser Met Ala Pro Asn Leu Lys Ala 
        275                 280                 285             


Gly Tyr Asn Leu Thr Ile Cys Tyr Phe Ala Ile Gly Asp Arg Glu Lys 
    290                 295                 300                 


Met Lys Lys Ala Phe Gln Lys Leu Ile Thr Val Pro Leu Glu Ile Asp 
305                 310                 315                 320 


Glu Asp Lys Tyr Ile Ser Pro Ser Asp Asp Pro His Thr Asn Leu Val 
                325                 330                 335     


Thr Glu Ala Ile Lys Asn Asp His Leu Arg Gln Met Glu Arg Glu Arg 
            340                 345                 350         


Lys Ala Met Ala Glu Lys Tyr Ile Met Thr Ser Ala Lys Leu Ile Ala 
        355                 360                 365             


Pro Val Ile Glu Thr Ser Phe Ala Ala Gly Tyr Asp Trp Cys Val Glu 
    370                 375                 380                 


Val Val Lys Ala Ser Gln Tyr Val Glu Leu Ala Asn Asp Leu Glu Ile 
385                 390                 395                 400 


Asn Lys Ala Val Thr Tyr Leu Arg Gln Lys Asp Tyr Asn Gln Ala Val 
                405                 410                 415     


Glu Ile Leu Lys Val Leu Glu Lys Lys Asp Ser Arg Val Lys Ser Ala 
            420                 425                 430         


Ala Ala Thr Asn Leu Ser Ala Leu Tyr Tyr Met Gly Lys Asp Phe Ala 
        435                 440                 445             


Gln Ala Ser Ser Tyr Ala Asp Ile Ala Val Asn Ser Asp Arg Tyr Asn 
    450                 455                 460                 


Pro Ala Ala Leu Thr Asn Lys Gly Asn Thr Val Phe Ala Asn Gly Asp 
465                 470                 475                 480 


Tyr Glu Lys Ala Ala Glu Phe Tyr Lys Glu Ala Leu Arg Asn Asp Ser 
                485                 490                 495     


Ser Cys Thr Glu Ala Leu Tyr Asn Ile Gly Leu Thr Tyr Glu Lys Leu 
            500                 505                 510         


Asn Arg Leu Asp Glu Ala Leu Asp Cys Phe Leu Lys Leu His Ala Ile 
        515                 520                 525             


Leu Arg Asn Ser Ala Glu Val Leu Tyr Gln Ile Ala Asn Ile Tyr Glu 
    530                 535                 540                 


Leu Met Glu Asn Pro Ser Gln Ala Ile Glu Trp Leu Met Gln Val Val 
545                 550                 555                 560 


Ser Val Ile Pro Thr Asp Pro Gln Val Leu Ser Lys Leu Gly Glu Leu 
                565                 570                 575     


Tyr Asp Arg Glu Gly Asp Lys Ser Gln Ala Phe Gln Tyr Tyr Tyr Glu 
            580                 585                 590         


Ser Tyr Arg Tyr Phe Pro Cys Asn Ile Glu Val Ile Glu Trp Leu Gly 
        595                 600                 605             


Ala Tyr Tyr Ile Asp Thr Gln Phe Trp Glu Lys Ala Ile Gln Tyr Phe 
    610                 615                 620                 


Glu Arg Ala Ser Leu Ile Gln Pro Thr Gln Val Lys Trp Gln Leu Met 
625                 630                 635                 640 


Val Ala Ser Cys Phe Arg Arg Ser Gly Asn Tyr Gln Lys Ala Leu Asp 
                645                 650                 655     


Thr Tyr Lys Asp Thr His Arg Lys Phe Pro Glu Asn Val Glu Cys Leu 
            660                 665                 670         


Arg Phe Leu Val Arg Leu Cys Thr Asp Leu Gly Leu Lys Asp Ala Gln 
        675                 680                 685             


Glu Tyr Ala Arg Lys Leu Lys Arg Leu Glu Lys Met Lys Glu Ile Arg 
    690                 695                 700                 


Glu Gln Arg Ile Lys Ser Gly Arg Asp Gly Ser Gly Gly Ser Arg Gly 
705                 710                 715                 720 


Lys Arg Glu Gly Ser Ala Ser Gly Asp Ser Gly Gln Asn Tyr Ser Ala 
                725                 730                 735     


Ser Ser Lys Gly Glu Arg Leu Ser Ala Arg Leu Arg Ala Leu Pro Gly 
            740                 745                 750         


Thr Asn Glu Pro Tyr Glu Ser Ser Ser Asn Lys Glu Ile Asp Ala Ser 
        755                 760                 765             


Tyr Val Asp Pro Leu Gly Pro Gln Ile Glu Arg Pro Lys Thr Ala Ala 
    770                 775                 780                 


Lys Lys Arg Ile Asp Glu Asp Asp Phe Ala Asp Glu Glu Leu Gly Asp 
785                 790                 795                 800 


Asp Leu Leu Pro Glu 
                805 


<210> 8736
<211> 254
<212> PRT
<213> Homo sapiens

<400> 8736
Met Ala Pro Gly Ser Phe Ala Glu Tyr Thr Val Val Pro Ala Ser Ile 
1               5                   10                  15      


Ala Thr Pro Val Pro Ser Val Lys Pro Glu Tyr Leu Thr Leu Leu Val 
            20                  25                  30          


Ser Gly Thr Thr Ala Tyr Ile Ser Leu Lys Glu Leu Gly Gly Leu Ser 
        35                  40                  45              


Glu Gly Lys Lys Val Leu Val Thr Ala Ala Ala Gly Gly Thr Gly Gln 
    50                  55                  60                  


Phe Ala Met Gln Leu Ser Lys Lys Ala Lys Cys His Val Ile Gly Thr 
65                  70                  75                  80  


Cys Ser Ser Asp Glu Lys Ser Ala Phe Leu Lys Ser Leu Gly Cys Asp 
                85                  90                  95      


Arg Pro Ile Asn Tyr Lys Thr Glu Pro Val Gly Thr Val Leu Lys Gln 
            100                 105                 110         


Glu Tyr Pro Glu Gly Val Asp Val Val Tyr Glu Ser Val Gly Gly Ala 
        115                 120                 125             


Met Phe Asp Leu Ala Val Asp Ala Leu Ala Thr Lys Gly Arg Leu Ile 
    130                 135                 140                 


Val Ile Gly Phe Ile Ser Gly Tyr Gln Thr Pro Thr Gly Leu Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Thr Leu Pro Ala Lys Leu Leu Lys Lys Ser Ala Ser 
                165                 170                 175     


Val Gln Gly Phe Phe Leu Asn His Tyr Leu Ser Lys Tyr Gln Ala Ala 
            180                 185                 190         


Met Ser His Leu Leu Glu Met Cys Val Ser Gly Asp Leu Val Cys Glu 
        195                 200                 205             


Val Asp Leu Gly Asp Leu Ser Pro Glu Gly Arg Phe Thr Gly Leu Glu 
    210                 215                 220                 


Ser Ile Phe Arg Ala Val Asn Tyr Met Tyr Met Gly Lys Asn Thr Gly 
225                 230                 235                 240 


Lys Ile Val Val Glu Leu Pro His Ser Val Asn Ser Lys Leu 
                245                 250                 


<210> 8737
<211> 403
<212> PRT
<213> Homo sapiens

<400> 8737
Met His His Pro Ile Gln Met Lys Pro Ala Asp Ser Glu Lys Ser Asn 
1               5                   10                  15      


Ala Val Glu Asp Arg Lys Leu Phe Ile Gly Met Val Ser Lys Lys Cys 
            20                  25                  30          


Asn Glu Asn Asp Ile Arg Val Met Phe Ser Pro Phe Gly Gln Ile Glu 
        35                  40                  45              


Glu Cys Arg Ile Leu Arg Gly Pro Asp Gly Leu Ser Arg Gly Cys Ala 
    50                  55                  60                  


Phe Val Thr Phe Ser Thr Arg Ala Met Ala Gln Asn Ala Ile Lys Ala 
65                  70                  75                  80  


Met His Gln Ser Gln Thr Met Glu Gly Cys Ser Ser Pro Ile Val Val 
                85                  90                  95      


Lys Phe Ala Asp Thr Gln Lys Asp Lys Glu Gln Arg Arg Leu Gln Gln 
            100                 105                 110         


Gln Leu Ala Gln Gln Met Gln Gln Leu Asn Thr Ala Thr Trp Gly Asn 
        115                 120                 125             


Leu Thr Gly Leu Gly Gly Leu Thr Pro Gln Tyr Leu Ala Leu Leu Gln 
    130                 135                 140                 


Gln Ala Thr Ser Ser Ser Asn Leu Gly Ala Phe Ser Gly Ile Gln Gln 
145                 150                 155                 160 


Met Ala Gly Met Asn Ala Leu Gln Leu Gln Asn Leu Ala Thr Leu Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Gln Thr Ser Ala Thr Ser Thr Asn Ala Asn 
            180                 185                 190         


Pro Leu Ser Thr Thr Ser Ser Ala Leu Gly Ala Leu Thr Ser Pro Val 
        195                 200                 205             


Ala Ala Ser Thr Pro Asn Ser Thr Ala Gly Ala Ala Met Asn Ser Leu 
    210                 215                 220                 


Thr Ser Leu Gly Thr Leu Gln Gly Leu Ala Gly Ala Thr Val Gly Leu 
225                 230                 235                 240 


Asn Asn Ile Asn Ala Leu Ala Val Ala Gln Met Leu Ser Gly Met Ala 
                245                 250                 255     


Ala Leu Asn Gly Gly Leu Gly Ala Thr Gly Leu Thr Asn Gly Thr Ala 
            260                 265                 270         


Gly Thr Met Asp Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr 
        275                 280                 285             


Ala Ala Ala Ala Leu Pro Thr Leu Tyr Ser Gln Ser Leu Leu Gln Gln 
    290                 295                 300                 


Gln Ser Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala Asn Leu 
305                 310                 315                 320 


Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln Asp Ile Leu Gln 
                325                 330                 335     


Met Phe Met Pro Phe Gly Asn Val Ile Ser Ala Lys Val Phe Ile Asp 
            340                 345                 350         


Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr Asp Asn 
        355                 360                 365             


Pro Val Ser Ala Gln Ala Ala Ile Gln Ala Met Asn Gly Phe Gln Ile 
    370                 375                 380                 


Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser Lys Asn Asp Ser 
385                 390                 395                 400 


Lys Pro Tyr 
            


<210> 8738
<211> 443
<212> PRT
<213> Homo sapiens

<400> 8738
Met Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val Glu Glu Gly Leu 
1               5                   10                  15      


His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala Thr Gln Leu Ala 
            20                  25                  30          


Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys Lys Ala Asp Lys 
        35                  40                  45              


Val Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met Thr Ala Leu Ser 
    50                  55                  60                  


Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala Lys Met Val Val 
65                  70                  75                  80  


Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu Lys Met Ile Gly 
                85                  90                  95      


Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Asp Ser Gln Leu Val Ala 
            100                 105                 110         


Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly Phe Glu Met Gln 
        115                 120                 125             


Pro Lys Lys Tyr His Asn Pro Lys Ile Ala Leu Leu Asn Val Glu Leu 
    130                 135                 140                 


Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg Val His Thr Val 
145                 150                 155                 160 


Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn Ile Leu Tyr Asp 
                165                 170                 175     


Lys Leu Glu Lys Ile His His Ser Gly Ala Lys Val Val Leu Ser Lys 
            180                 185                 190         


Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala Asp Arg Asp Met 
        195                 200                 205             


Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys Arg Thr Met Met 
    210                 215                 220                 


Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala Leu Ser Ala Asp 
225                 230                 235                 240 


Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln Ile Gly Gly Glu 
                245                 250                 255     


Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys Thr Cys Thr Phe 
            260                 265                 270         


Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu Thr Glu Arg Ser 
        275                 280                 285             


Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile Lys Asn Asp Ser 
    290                 295                 300                 


Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu Ser Lys Tyr Leu 
305                 310                 315                 320 


Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln Leu Leu Ile Gly 
                325                 330                 335     


Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln Leu Cys Asp Asn 
            340                 345                 350         


Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu Arg Ala Arg His 
        355                 360                 365             


Ala Gln Gly Gly Thr Trp Tyr Gly Val Asp Ile Asn Asn Glu Asp Ile 
    370                 375                 380                 


Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala Met Val Arg Ile 
385                 390                 395                 400 


Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu Ile Val Ser Val 
                405                 410                 415     


Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp Ala Pro Thr Ala 
            420                 425                 430         


Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His 
        435                 440             


<210> 8739
<211> 730
<212> PRT
<213> Homo sapiens

<400> 8739
Met Gln Leu Phe Glu Gln Pro Cys Pro Gly Glu Asp Pro Arg Pro Gly 
1               5                   10                  15      


Gly Gln Ile Gly Glu Val Glu Leu Ser Ser Tyr Thr Pro Pro Ala Gly 
            20                  25                  30          


Val Pro Gly Lys Pro Ala Ala Pro His Phe Leu Pro Val Leu Cys Ser 
        35                  40                  45              


Val Ser Pro Ser Gly Ser Arg Val Pro His Asp Leu Leu Gly Gly Ser 
    50                  55                  60                  


Gly Gly Phe Thr Leu Glu Asp Ala Leu Phe Gly Leu Leu Phe Gly Ala 
65                  70                  75                  80  


Asp Ala Thr Leu Leu Gln Ser Pro Val Val Leu Cys Gly Leu Pro Asp 
                85                  90                  95      


Gly Gln Leu Cys Cys Val Ile Leu Lys Ala Leu Val Thr Ser Arg Ser 
            100                 105                 110         


Ala Pro Gly Asp Pro Asn Ala Leu Val Lys Ile Leu His His Leu Glu 
        115                 120                 125             


Glu Pro Val Ile Phe Ile Gly Ala Leu Lys Thr Glu Pro Gln Ala Ala 
    130                 135                 140                 


Glu Ala Ala Glu Asn Phe Leu Pro Asp Glu Asp Val His Cys Asp Cys 
145                 150                 155                 160 


Leu Val Ala Phe Gly His His Gly Arg Met Leu Ala Ile Lys Ala Ser 
                165                 170                 175     


Trp Asp Glu Ser Gly Lys Leu Val Pro Glu Leu Arg Glu Tyr Cys Leu 
            180                 185                 190         


Pro Gly Pro Val Leu Cys Ala Ala Cys Gly Gly Gly Gly Arg Val Tyr 
        195                 200                 205             


His Ser Thr Pro Ser Asp Leu Cys Val Val Asp Leu Ser Arg Gly Ser 
    210                 215                 220                 


Thr Pro Leu Gly Pro Glu Gln Pro Glu Glu Gly Pro Gly Gly Leu Pro 
225                 230                 235                 240 


Pro Met Leu Cys Pro Ala Ser Leu Asn Ile Cys Ser Val Val Ser Leu 
                245                 250                 255     


Ser Ala Ser Pro Arg Thr His Glu Gly Gly Thr Lys Leu Leu Ala Leu 
            260                 265                 270         


Ser Ala Lys Gly Arg Leu Met Thr Cys Ser Leu Asp Leu Asp Ser Glu 
        275                 280                 285             


Met Pro Gly Pro Ala Arg Met Thr Thr Glu Ser Ala Gly Gln Lys Ile 
    290                 295                 300                 


Lys Glu Leu Leu Ser Gly Ile Gly Asn Ile Ser Glu Arg Val Ser Phe 
305                 310                 315                 320 


Leu Lys Lys Ala Val Asp Gln Arg Asn Lys Ala Leu Thr Ser Leu Asn 
                325                 330                 335     


Glu Ala Met Asn Val Ser Cys Ala Leu Leu Ser Ser Gly Thr Gly Pro 
            340                 345                 350         


Arg Pro Ile Ser Cys Thr Thr Ser Thr Thr Trp Ser Arg Leu Gln Thr 
        355                 360                 365             


Gln Asp Val Leu Met Ala Thr Cys Val Leu Glu Asn Ser Ser Ser Phe 
    370                 375                 380                 


Ser Leu Asp Gln Gly Trp Thr Leu Cys Ile Gln Val Leu Thr Ser Ser 
385                 390                 395                 400 


Cys Ala Leu Asp Leu Asp Ser Ala Cys Ser Ala Ile Thr Tyr Thr Ile 
                405                 410                 415     


Pro Val Asp Gln Leu Gly Pro Gly Ala Arg Arg Glu Val Thr Leu Pro 
            420                 425                 430         


Leu Gly Pro Gly Glu Asn Gly Gly Leu Asp Leu Pro Val Thr Val Ser 
        435                 440                 445             


Cys Thr Leu Phe Tyr Ser Leu Arg Glu Val Val Gly Gly Ala Leu Ala 
    450                 455                 460                 


Pro Ser Asp Ser Glu Asp Pro Phe Leu Asp Glu Cys Pro Ser Asp Val 
465                 470                 475                 480 


Leu Pro Glu Gln Glu Gly Val Cys Leu Pro Leu Ser Arg His Thr Val 
                485                 490                 495     


Asp Met Leu Gln Cys Leu Arg Phe Pro Gly Leu Ala Pro Pro His Thr 
            500                 505                 510         


Arg Ala Pro Ser Pro Leu Gly Pro Thr Arg Asp Pro Val Ala Thr Phe 
        515                 520                 525             


Leu Glu Thr Cys Arg Glu Pro Gly Ser Gln Pro Ala Gly Pro Ala Ser 
    530                 535                 540                 


Leu Arg Ala Glu Tyr Leu Pro Pro Ser Val Ala Ser Ile Lys Val Ser 
545                 550                 555                 560 


Ala Glu Leu Leu Arg Ala Ala Leu Lys Asp Gly His Ser Gly Val Pro 
                565                 570                 575     


Leu Cys Cys Ala Thr Leu Gln Trp Leu Leu Ala Glu Asn Ala Ala Val 
            580                 585                 590         


Asp Val Val Arg Ala Arg Ala Leu Ser Ser Ile Gln Gly Val Ala Pro 
        595                 600                 605             


Asp Gly Ala Asn Val His Leu Ile Val Arg Glu Val Ala Met Thr Asp 
    610                 615                 620                 


Leu Cys Pro Ala Gly Pro Ile Gln Ala Val Glu Ile Gln Val Glu Ser 
625                 630                 635                 640 


Ser Ser Leu Ala Asp Ile Cys Arg Ala His His Ala Val Val Gly Arg 
                645                 650                 655     


Met Gln Thr Met Val Thr Glu Gln Ala Thr Gln Gly Ser Ser Ala Pro 
            660                 665                 670         


Asp Leu Arg Val Gln Tyr Leu Arg Gln Ile His Ala Asn His Glu Thr 
        675                 680                 685             


Leu Leu Arg Glu Val Gln Thr Leu Arg Asp Arg Leu Cys Thr Glu Asp 
    690                 695                 700                 


Glu Ala Ser Ser Cys Ala Thr Ala Gln Arg Leu Leu Gln Val Tyr Arg 
705                 710                 715                 720 


Gln Leu Arg His Pro Ser Leu Ile Leu Leu 
                725                 730 


<210> 8740
<211> 1392
<212> PRT
<213> Homo sapiens

<400> 8740
Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95      


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110         


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125             


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140                 


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175     


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190         


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205             


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220                 


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240 


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255     


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270         


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285             


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300                 


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320 


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 
                325                 330                 335     


Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala 
            340                 345                 350         


Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu Leu 
        355                 360                 365             


Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser His 
    370                 375                 380                 


Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala Arg Asp Gly His Asp 
385                 390                 395                 400 


Gln His Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met 
                405                 410                 415     


Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 
            420                 425                 430         


Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 
        435                 440                 445             


Ser Ile Thr Lys Gly Asp Leu Glu Val Ala Thr Val Ser Glu Lys Ser 
    450                 455                 460                 


Arg Ile Met Glu Leu Glu Lys Asp Leu Ala Leu Arg Val Gln Glu Val 
465                 470                 475                 480 


Ala Glu Leu Arg Arg Arg Leu Glu Ser Asn Lys Pro Ala Gly Asp Val 
                485                 490                 495     


Asp Met Ser Leu Ser Leu Leu Gln Glu Ile Ser Ser Leu Gln Glu Lys 
            500                 505                 510         


Leu Glu Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr Ser Leu Lys 
        515                 520                 525             


Glu His Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu Ile Lys Ala 
    530                 535                 540                 


Leu Tyr Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu Ser Leu Lys 
545                 550                 555                 560 


Ser Lys Leu Glu His Ala Asn Lys Glu Asn Ser Asp Val Ile Ala Leu 
                565                 570                 575     


Trp Lys Ser Lys Leu Glu Thr Ala Ile Ala Ser His Gln Gln Ala Met 
            580                 585                 590         


Glu Glu Leu Lys Val Ser Phe Ser Lys Gly Leu Gly Thr Glu Thr Ala 
        595                 600                 605             


Glu Phe Ala Glu Leu Lys Thr Gln Ile Glu Lys Met Arg Leu Asp Tyr 
    610                 615                 620                 


Gln His Glu Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser Glu Arg Ala 
625                 630                 635                 640 


Ala His Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu Met Lys Val 
                645                 650                 655     


Ile Lys Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser Lys Leu Asp 
            660                 665                 670         


Lys Ala Glu Asp Gln His Leu Val Glu Met Glu Asp Thr Leu Asn Lys 
        675                 680                 685             


Leu Gln Glu Ala Glu Ile Lys Val Lys Glu Leu Glu Val Leu Gln Ala 
    690                 695                 700                 


Lys Cys Asn Glu Gln Thr Lys Val Ile Asp Asn Phe Thr Ser Gln Leu 
705                 710                 715                 720 


Lys Ala Thr Glu Glu Lys Leu Leu Asp Leu Asp Ala Leu Arg Lys Ala 
                725                 730                 735     


Ser Ser Glu Gly Lys Ser Glu Met Lys Lys Leu Arg Gln Gln Leu Glu 
            740                 745                 750         


Ala Ala Glu Lys Gln Ile Lys His Leu Glu Ile Glu Lys Asn Ala Glu 
        755                 760                 765             


Ser Ser Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly Arg Glu Leu 
    770                 775                 780                 


Lys Leu Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser Gln Val Lys 
785                 790                 795                 800 


Glu Thr Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys Phe Ala Glu 
                805                 810                 815     


Ala Ser Glu Glu Ala Val Ser Val Gln Arg Ser Met Gln Glu Thr Val 
            820                 825                 830         


Asn Lys Leu His Gln Lys Glu Glu Gln Phe Asn Met Leu Ser Ser Asp 
        835                 840                 845             


Leu Glu Lys Leu Arg Glu Asn Leu Ala Asp Met Glu Ala Lys Phe Arg 
    850                 855                 860                 


Glu Lys Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys Glu Lys Leu 
865                 870                 875                 880 


Glu Asn Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp Asn Ser Ser 
                885                 890                 895     


Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu Arg Asp Val 
            900                 905                 910         


Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn Ala Ser Phe 
        915                 920                 925             


Leu Gln Lys Ser Ile Glu Asp Met Thr Val Lys Ala Glu Gln Ser Gln 
    930                 935                 940                 


Gln Glu Ala Ala Lys Lys His Glu Glu Glu Lys Lys Glu Leu Glu Arg 
945                 950                 955                 960 


Lys Leu Ser Asp Leu Glu Lys Lys Met Glu Thr Ser His Asn Gln Cys 
                965                 970                 975     


Gln Glu Leu Lys Ala Arg Tyr Glu Arg Ala Thr Ser Glu Thr Lys Thr 
            980                 985                 990         


Lys His Glu Glu Ile Leu Gln Asn  Leu Gln Lys Thr Leu  Leu Asp Thr 
        995                 1000                 1005             


Glu Asp  Lys Leu Lys Gly Ala  Arg Glu Glu Asn Ser  Gly Leu Leu 
    1010                 1015                 1020             


Gln Glu  Leu Glu Glu Leu Arg  Lys Gln Ala Asp Lys  Ala Lys Ala 
    1025                 1030                 1035             


Ala Gln  Thr Ala Glu Asp Ala  Met Gln Ile Met Glu  Gln Met Thr 
    1040                 1045                 1050             


Lys Glu  Lys Thr Glu Thr Leu  Ala Ser Leu Glu Asp  Thr Lys Gln 
    1055                 1060                 1065             


Thr Asn  Ala Lys Leu Gln Asn  Glu Leu Asp Thr Leu  Lys Glu Asn 
    1070                 1075                 1080             


Asn Leu  Lys Asn Val Glu Glu  Leu Asn Lys Ser Lys  Glu Leu Leu 
    1085                 1090                 1095             


Thr Val  Glu Asn Gln Lys Met  Glu Glu Phe Arg Lys  Glu Ile Glu 
    1100                 1105                 1110             


Thr Leu  Lys Gln Ala Ala Ala  Gln Lys Ser Gln Gln  Leu Ser Ala 
    1115                 1120                 1125             


Leu Gln  Glu Glu Asn Val Lys  Leu Ala Glu Glu Leu  Gly Arg Ser 
    1130                 1135                 1140             


Arg Asp  Glu Val Thr Ser His  Gln Lys Leu Glu Glu  Glu Arg Ser 
    1145                 1150                 1155             


Val Leu  Asn Asn Gln Leu Leu  Glu Met Lys Lys Arg  Glu Ser Lys 
    1160                 1165                 1170             


Phe Ile  Lys Asp Ala Asp Glu  Glu Lys Ala Ser Leu  Gln Lys Ser 
    1175                 1180                 1185             


Ile Ser  Ile Thr Ser Ala Leu  Leu Thr Glu Lys Asp  Ala Glu Leu 
    1190                 1195                 1200             


Glu Lys  Leu Arg Asn Glu Val  Thr Val Leu Arg Gly  Glu Asn Ala 
    1205                 1210                 1215             


Ser Ala  Lys Ser Leu His Ser  Val Val Gln Thr Leu  Glu Ser Asp 
    1220                 1225                 1230             


Lys Val  Lys Leu Glu Leu Lys  Val Lys Asn Leu Glu  Leu Gln Leu 
    1235                 1240                 1245             


Lys Glu  Asn Lys Arg Gln Leu  Ser Ser Ser Ser Gly  Asn Thr Asp 
    1250                 1255                 1260             


Thr Gln  Ala Asp Glu Asp Glu  Arg Ala Gln Glu Ser  Gln Ile Asp 
    1265                 1270                 1275             


Phe Leu  Asn Ser Val Ile Val  Asp Leu Gln Arg Lys  Asn Gln Asp 
    1280                 1285                 1290             


Leu Lys  Met Lys Val Glu Met  Met Ser Glu Ala Ala  Leu Asn Gly 
    1295                 1300                 1305             


Asn Gly  Asp Asp Leu Asn Asn  Tyr Asp Ser Asp Asp  Gln Glu Lys 
    1310                 1315                 1320             


Gln Ser  Lys Lys Lys Pro Arg  Leu Phe Cys Asp Ile  Cys Asp Cys 
    1325                 1330                 1335             


Phe Asp  Leu His Asp Thr Glu  Asp Cys Pro Thr Gln  Ala Gln Met 
    1340                 1345                 1350             


Ser Glu  Asp Pro Pro His Ser  Thr His His Gly Ser  Arg Gly Glu 
    1355                 1360                 1365             


Glu Arg  Pro Tyr Cys Glu Ile  Cys Glu Met Phe Gly  His Trp Ala 
    1370                 1375                 1380             


Thr Asn  Cys Asn Asp Asp Glu  Thr Phe 
    1385                 1390         


<210> 8741
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8741
Met Phe Arg Lys Ile Gly Ile Glu Ala Leu Lys Gln Val Thr Lys Arg 
1               5                   10                  15      


Tyr Ala Arg Lys Gln Asn Arg Trp Val Lys Asn Arg Phe Leu Ser Arg 
            20                  25                  30          


Pro Gly Pro Ile Val Pro Pro Val Tyr Gly Leu Glu Val Ser Asp Val 
        35                  40                  45              


Ser Lys Trp Glu Glu Ser Val Leu Glu Pro Ala Leu Glu Ile Val Gln 
    50                  55                  60                  


Ser Phe Ile Gln Gly His Lys Pro Thr Ala Thr Pro Ile Lys Met Pro 
65                  70                  75                  80  


Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr His Leu Cys Asp Leu Cys 
                85                  90                  95      


Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp Ala Ala His Ile Lys Ser 
            100                 105                 110         


Lys Ser His Leu Asn Gln Leu Lys Lys Arg Arg Arg Leu Asp Ser Asp 
        115                 120                 125             


Ala Val Asn Thr Ile Glu Ser Gln Ser Val Ser Pro Asp His Asn Lys 
    130                 135                 140                 


Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln Asn Asp Gln Glu Leu Lys 
145                 150                 155                 160 


Cys Ser Val 
            


<210> 8742
<211> 533
<212> PRT
<213> Homo sapiens

<400> 8742
Met Ala Ser Pro Gly Lys Asp Asn Tyr Arg Met Lys Ser Tyr Lys Asn 
1               5                   10                  15      


Asn Ala Leu Asn Pro Glu Glu Met Arg Arg Arg Arg Glu Glu Glu Gly 
            20                  25                  30          


Ile Gln Leu Arg Lys Gln Lys Arg Glu Gln Gln Leu Phe Lys Arg Arg 
        35                  40                  45              


Asn Val Glu Leu Ile Asn Glu Glu Ala Ala Met Phe Asp Ser Leu Leu 
    50                  55                  60                  


Met Asp Ser Tyr Val Ser Ser Thr Thr Gly Glu Ser Val Ile Thr Arg 
65                  70                  75                  80  


Glu Met Val Glu Met Leu Phe Ser Asp Asp Ser Asp Leu Gln Leu Ala 
                85                  90                  95      


Thr Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys Glu Pro Ser Pro Pro 
            100                 105                 110         


Ile Asp Glu Val Ile Asn Thr Pro Arg Val Val Asp Arg Phe Val Glu 
        115                 120                 125             


Phe Leu Lys Arg Asn Glu Asn Cys Thr Leu Gln Phe Glu Ala Ala Trp 
    130                 135                 140                 


Ala Leu Thr Asn Ile Ala Ser Gly Thr Ser Gln Gln Thr Lys Ile Val 
145                 150                 155                 160 


Ile Glu Ala Gly Ala Val Pro Ile Phe Ile Glu Leu Leu Asn Ser Asp 
                165                 170                 175     


Phe Glu Asp Val Gln Glu Gln Ala Val Trp Ala Leu Gly Asn Ile Ala 
            180                 185                 190         


Gly Asp Ser Ser Val Cys Arg Asp Tyr Val Leu Asn Cys Ser Ile Leu 
        195                 200                 205             


Asn Pro Leu Leu Thr Leu Leu Thr Lys Ser Thr Arg Leu Thr Met Thr 
    210                 215                 220                 


Arg Asn Ala Val Trp Ala Leu Ser Asn Leu Cys Arg Gly Lys Asn Pro 
225                 230                 235                 240 


Pro Pro Glu Phe Ala Lys Val Ser Pro Cys Leu Pro Val Leu Ser Arg 
                245                 250                 255     


Leu Leu Phe Ser Ser Asp Ser Asp Leu Leu Ala Asp Ala Cys Trp Ala 
            260                 265                 270         


Leu Ser Tyr Leu Ser Asp Gly Pro Asn Glu Lys Ile Gln Ala Val Ile 
        275                 280                 285             


Asp Ser Gly Val Cys Arg Arg Leu Val Glu Leu Leu Met His Asn Asp 
    290                 295                 300                 


Tyr Lys Val Ala Ser Pro Ala Leu Arg Ala Val Gly Asn Ile Val Thr 
305                 310                 315                 320 


Gly Asp Asp Ile Gln Thr Gln Val Ile Leu Asn Cys Ser Ala Leu Pro 
                325                 330                 335     


Cys Leu Leu His Leu Leu Ser Ser Pro Lys Glu Ser Ile Arg Lys Glu 
            340                 345                 350         


Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala Gly Asn Arg Ala Gln Ile 
        355                 360                 365             


Gln Ala Val Ile Asp Ala Asn Ile Phe Pro Val Leu Ile Glu Ile Leu 
    370                 375                 380                 


Gln Lys Ala Glu Phe Arg Thr Arg Lys Glu Ala Ala Trp Ala Ile Thr 
385                 390                 395                 400 


Asn Ala Thr Ser Gly Gly Thr Pro Glu Gln Ile Arg Tyr Leu Val Ser 
                405                 410                 415     


Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu Thr Val Met Asp Ser 
            420                 425                 430         


Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu Asn Ile Leu Arg Leu 
        435                 440                 445             


Gly Glu Gln Glu Gly Lys Arg Ser Gly Ser Gly Val Asn Pro Tyr Cys 
    450                 455                 460                 


Gly Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys Ile Glu Phe Leu Gln 
465                 470                 475                 480 


Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala Phe Asp Leu Ile Glu 
                485                 490                 495     


His Tyr Phe Gly Val Glu Asp Asp Asp Ser Ser Leu Ala Pro Gln Val 
            500                 505                 510         


Asp Glu Thr Gln Gln Gln Phe Ile Phe Gln Gln Pro Glu Ala Pro Met 
        515                 520                 525             


Glu Gly Phe Gln Leu 
    530             


<210> 8743
<211> 330
<212> PRT
<213> Homo sapiens

<400> 8743
Met Glu Arg Phe Met Glu Gln Val Val Phe Lys Tyr Leu Arg Ala Glu 
1               5                   10                  15      


Pro Glu Asp His Tyr Phe Leu Met Thr Glu Pro Pro Leu Asn Thr Pro 
            20                  25                  30          


Glu Asn Arg Glu Tyr Leu Ala Glu Ile Met Phe Glu Ser Phe Asn Val 
        35                  40                  45              


Pro Gly Leu Tyr Ile Ala Val Gln Ala Val Leu Ala Leu Ala Ala Ser 
    50                  55                  60                  


Trp Thr Ser Arg Gln Val Gly Glu Arg Thr Leu Thr Gly Ile Val Ile 
65                  70                  75                  80  


Asp Ser Gly Asp Gly Val Thr His Val Ile Pro Val Ala Glu Gly Tyr 
                85                  90                  95      


Val Ile Gly Ser Cys Ile Lys His Ile Pro Ile Ala Gly Arg Asp Ile 
            100                 105                 110         


Thr Tyr Phe Ile Gln Gln Leu Leu Arg Glu Arg Glu Val Gly Ile Pro 
        115                 120                 125             


Pro Glu Gln Ser Leu Glu Thr Ala Lys Ala Ile Lys Glu Lys Tyr Cys 
    130                 135                 140                 


Tyr Ile Cys Pro Asp Ile Val Lys Glu Phe Ala Lys Tyr Asp Val Asp 
145                 150                 155                 160 


Pro Arg Lys Trp Ile Lys Gln Tyr Thr Gly Ile Asn Ala Ile Asn Gln 
                165                 170                 175     


Lys Lys Phe Val Ile Asp Val Gly Tyr Glu Arg Phe Leu Gly Pro Glu 
            180                 185                 190         


Ile Phe Phe His Pro Glu Phe Ala Asn Pro Asp Phe Met Glu Ser Ile 
        195                 200                 205             


Ser Asp Val Val Asp Glu Val Ile Gln Asn Cys Pro Ile Asp Val Arg 
    210                 215                 220                 


Arg Pro Leu Tyr Lys Asn Val Val Leu Ser Gly Gly Ser Thr Met Phe 
225                 230                 235                 240 


Arg Asp Phe Gly Arg Arg Leu Gln Arg Asp Leu Lys Arg Val Val Asp 
                245                 250                 255     


Ala Arg Leu Arg Leu Ser Glu Glu Leu Ser Gly Gly Arg Ile Lys Pro 
            260                 265                 270         


Lys Pro Val Glu Val Gln Val Val Thr His His Met Gln Arg Tyr Ala 
        275                 280                 285             


Val Trp Phe Gly Gly Ser Met Leu Ala Ser Thr Pro Glu Phe Phe Gln 
    290                 295                 300                 


Val Cys His Thr Lys Lys Asp Tyr Glu Glu Tyr Gly Pro Ser Ile Cys 
305                 310                 315                 320 


Arg His Asn Pro Val Phe Gly Val Met Ser 
                325                 330 


<210> 8744
<211> 191
<212> PRT
<213> Homo sapiens

<400> 8744
Met Ser Arg Glu Arg Gly Ser Arg Ser Glu Glu Pro Gly Ala Gly Asn 
1               5                   10                  15      


Arg Glu Ser Gly Ser Arg Glu Pro Gly Leu Ala Ala Ala Ala Met Ser 
            20                  25                  30          


Thr Val Asp Leu Ala Arg Val Gly Ala Cys Ile Leu Lys His Ala Val 
        35                  40                  45              


Thr Gly Glu Ala Val Glu Leu Arg Ser Leu Trp Arg Glu His Ala Cys 
    50                  55                  60                  


Val Val Ala Gly Leu Arg Arg Phe Gly Cys Val Val Cys Arg Trp Ile 
65                  70                  75                  80  


Ala Gln Asp Leu Ser Ser Leu Ala Gly Leu Leu Asp Gln His Gly Val 
                85                  90                  95      


Arg Leu Val Gly Val Gly Pro Glu Ala Leu Gly Leu Gln Glu Phe Leu 
            100                 105                 110         


Asp Gly Asp Tyr Phe Ala Gly Glu Leu Tyr Leu Asp Glu Ser Lys Gln 
        115                 120                 125             


Leu Tyr Lys Glu Leu Gly Phe Lys Arg Tyr Asn Ser Leu Ser Ile Leu 
    130                 135                 140                 


Pro Ala Ala Leu Gly Lys Pro Val Arg Asp Val Ala Ala Lys Ser Pro 
145                 150                 155                 160 


Gly Asp Tyr Val Pro Lys Glu His Ile Leu Gln Val Leu Gly Ile Ser 
                165                 170                 175     


Ala Glu Val Cys Ala Ser Asp Pro Pro Gln Cys Asp Arg Glu Val 
            180                 185                 190     


<210> 8745
<211> 349
<212> PRT
<213> Homo sapiens

<400> 8745
Asn Thr Ile His Asp Val Leu Asp Val Glu Ala Ala Val Val Asn Leu 
1               5                   10                  15      


Asp Asn Ser Val Val Asp Leu Glu Thr Leu Gln Ala Leu Tyr Glu Asn 
            20                  25                  30          


Arg Ala Gln Ser Asp Glu Leu Glu Lys Ile Glu Lys His Gly Arg Ser 
        35                  40                  45              


Ser Lys Asp Lys Glu Asn Ala Lys Ser Leu Asp Lys Pro Glu Gln Phe 
    50                  55                  60                  


Leu Tyr Glu Leu Ser Leu Ile Pro Asn Phe Ser Glu Arg Val Phe Cys 
65                  70                  75                  80  


Ile Leu Phe Gln Ser Thr Phe Ser Glu Ser Ile Cys Ser Ile Arg Arg 
                85                  90                  95      


Lys Leu Glu Leu Leu Gln Lys Leu Cys Glu Thr Leu Lys Asn Gly Pro 
            100                 105                 110         


Gly Val Met Gln Val Leu Gly Leu Val Leu Ala Phe Gly Asn Tyr Met 
        115                 120                 125             


Asn Gly Gly Asn Lys Thr Arg Gly Gln Ala Asp Gly Phe Gly Leu Asp 
    130                 135                 140                 


Ile Leu Pro Lys Leu Lys Asp Val Lys Ser Ser Asp Asn Ser Arg Ser 
145                 150                 155                 160 


Leu Leu Ser Tyr Ile Val Ser Tyr Tyr Leu Arg Asn Phe Asp Glu Asp 
                165                 170                 175     


Ala Gly Lys Glu Gln Cys Leu Phe Pro Leu Pro Glu Pro Gln Asp Leu 
            180                 185                 190         


Phe Gln Ala Ser Gln Met Lys Phe Glu Asp Phe Gln Lys Asp Leu Arg 
        195                 200                 205             


Lys Leu Lys Lys Asp Leu Lys Ala Cys Glu Val Glu Ala Gly Lys Val 
    210                 215                 220                 


Tyr Gln Val Ser Ser Lys Glu His Met Gln Pro Phe Lys Glu Asn Met 
225                 230                 235                 240 


Glu Gln Phe Ile Ile Gln Ala Lys Ile Asp Gln Glu Ala Glu Glu Asn 
                245                 250                 255     


Ser Leu Thr Glu Thr His Lys Cys Phe Leu Glu Thr Thr Ala Tyr Phe 
            260                 265                 270         


Phe Met Lys Pro Lys Leu Gly Glu Lys Glu Val Ser Pro Asn Ala Phe 
        275                 280                 285             


Phe Ser Ile Trp His Glu Phe Ser Ser Asp Phe Lys Asp Phe Trp Lys 
    290                 295                 300                 


Lys Glu Asn Lys Leu Leu Leu Gln Glu Arg Val Lys Glu Ala Glu Glu 
305                 310                 315                 320 


Val Cys Arg Gln Lys Lys Gly Lys Ser Leu Tyr Lys Ile Lys Pro Arg 
                325                 330                 335     


His Asp Ser Gly Ile Lys Asn Asn Asn Ser Met His Thr 
            340                 345                 


<210> 8746
<211> 189
<212> PRT
<213> Homo sapiens

<400> 8746
Met Thr Ala Ser Ala Ser Ser Phe Ser Ser Ser Gln Gly Val Gln Gln 
1               5                   10                  15      


Pro Ser Ile Tyr Ser Phe Ser Gln Ile Thr Arg Ser Leu Phe Leu Ser 
            20                  25                  30          


Asn Gly Val Ala Ala Asn Asp Lys Leu Leu Leu Ser Ser Asn Arg Ile 
        35                  40                  45              


Thr Ala Ile Val Asn Ala Ser Val Glu Gly Gln Arg Ile Leu Arg Gly 
    50                  55                  60                  


Ile Gln Tyr Ile Lys Val Pro Val Thr Asp Ala Arg Asp Ser Arg Leu 
65                  70                  75                  80  


Tyr Asp Phe Phe Asp Pro Ile Ala Asp Leu Ile His Thr Ile Asp Met 
                85                  90                  95      


Arg Gln Gly Arg Thr Leu Leu His Cys Met Ala Gly Val Ser Arg Ser 
            100                 105                 110         


Ala Ser Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ser Met Ser Leu 
        115                 120                 125             


Leu Asp Ala His Thr Trp Thr Lys Ser Arg Arg Pro Ile Ile Arg Pro 
    130                 135                 140                 


Asn Asn Gly Phe Trp Glu Gln Leu Ile Asn Tyr Glu Phe Lys Leu Phe 
145                 150                 155                 160 


Asn Asn Asn Thr Val Arg Met Ile Asn Ser Pro Val Gly Asn Ile Pro 
                165                 170                 175     


Asp Ile Tyr Glu Lys Asp Leu Arg Met Met Ile Ser Met 
            180                 185                 


<210> 8747
<211> 182
<212> PRT
<213> Homo sapiens

<400> 8747
Met Ser Gly Arg Ser Val Pro His Ala His Pro Ala Thr Ala Glu Tyr 
1               5                   10                  15      


Glu Phe Ala Asn Pro Ser Arg Leu Gly Glu Gln Arg Phe Gly Glu Gly 
            20                  25                  30          


Leu Leu Pro Glu Glu Ile Leu Thr Pro Thr Leu Tyr His Gly Tyr Tyr 
        35                  40                  45              


Val Arg Pro Arg Ala Ala Pro Ala Gly Glu Gly Ser Arg Ala Gly Ala 
    50                  55                  60                  


Ser Glu Leu Arg Leu Ser Glu Gly Lys Phe Gln Ala Phe Leu Asp Val 
65                  70                  75                  80  


Ser His Phe Thr Pro Asp Glu Val Thr Val Arg Thr Val Asp Asn Leu 
                85                  90                  95      


Leu Glu Val Ser Ala Arg His Pro Gln Arg Leu Asp Arg His Gly Phe 
            100                 105                 110         


Val Ser Arg Glu Phe Cys Arg Thr Tyr Val Leu Pro Ala Asp Val Asp 
        115                 120                 125             


Pro Trp Arg Val Arg Ala Ala Leu Ser His Asp Gly Ile Leu Asn Leu 
    130                 135                 140                 


Glu Ala Pro Arg Gly Gly Arg His Leu Asp Thr Glu Val Asn Glu Val 
145                 150                 155                 160 


Tyr Ile Ser Leu Leu Pro Ala Pro Pro Asp Pro Glu Glu Glu Glu Glu 
                165                 170                 175     


Ala Ala Ile Val Glu Pro 
            180         


<210> 8748
<211> 128
<212> PRT
<213> Homo sapiens

<400> 8748
Met Val Phe Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser 
1               5                   10                  15      


Phe Gly Pro His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp 
            20                  25                  30          


Gln Asn Arg Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln 
        35                  40                  45              


Ala Met Pro Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe 
    50                  55                  60                  


Pro His Ser Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala 
65                  70                  75                  80  


Asp Ile Asn Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu 
                85                  90                  95      


Ala Arg Glu Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val 
            100                 105                 110         


Met Lys Ala Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Asp Thr Arg 
        115                 120                 125             


<210> 8749
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8749
Met Phe Arg Lys Ile Gly Ile Glu Ala Leu Lys Gln Val Thr Lys Arg 
1               5                   10                  15      


Tyr Ala Arg Lys Gln Asn Arg Trp Val Lys Asn Arg Phe Leu Ser Arg 
            20                  25                  30          


Pro Gly Pro Ile Val Pro Pro Val Tyr Gly Leu Glu Val Ser Asp Val 
        35                  40                  45              


Ser Lys Trp Glu Glu Ser Val Leu Glu Pro Ala Leu Glu Ile Val Gln 
    50                  55                  60                  


Ser Phe Ile Gln Gly His Lys Pro Thr Ala Thr Pro Ile Lys Met Pro 
65                  70                  75                  80  


Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr His Leu Cys Asp Leu Cys 
                85                  90                  95      


Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp Ala Ala His Ile Lys Ser 
            100                 105                 110         


Lys Ser His Leu Asn Gln Leu Lys Lys Arg Arg Arg Leu Asp Ser Asp 
        115                 120                 125             


Ala Val Asn Thr Ile Glu Ser Gln Ser Val Ser Pro Asp His Asn Lys 
    130                 135                 140                 


Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln Asn Asp Gln Glu Leu Lys 
145                 150                 155                 160 


Cys Ser Val 
            


<210> 8750
<211> 407
<212> PRT
<213> Homo sapiens

<400> 8750
Met Ala Ala Glu Leu Tyr Ala Pro Ala Ser Ala Ala Ala Ala Asp Leu 
1               5                   10                  15      


Ala Asn Ser Asn Ala Gly Ala Ala Val Gly Arg Lys Ala Gly Pro Arg 
            20                  25                  30          


Ser Pro Pro Ser Ala Pro Ala Pro Ala Pro Pro Pro Pro Ala Pro Ala 
        35                  40                  45              


Pro Pro Thr Leu Gly Asn Asn His Gln Glu Ser Pro Gly Trp Arg Cys 
    50                  55                  60                  


Cys Arg Pro Thr Leu Arg Glu Arg Asn Ala Leu Met Phe Asn Asn Glu 
65                  70                  75                  80  


Leu Met Ala Asp Val His Phe Val Val Gly Pro Pro Gly Ala Thr Arg 
                85                  90                  95      


Thr Val Pro Ala His Lys Tyr Val Leu Ala Val Gly Ser Ser Val Phe 
            100                 105                 110         


Tyr Ala Met Phe Tyr Gly Asp Leu Ala Glu Val Lys Ser Glu Ile His 
        115                 120                 125             


Ile Pro Asp Val Glu Pro Ala Ala Phe Leu Ile Leu Leu Lys Tyr Met 
    130                 135                 140                 


Tyr Ser Asp Glu Ile Asp Leu Glu Ala Asp Thr Val Leu Ala Thr Leu 
145                 150                 155                 160 


Tyr Ala Ala Lys Lys Tyr Ile Val Pro Ala Leu Ala Lys Ala Cys Val 
                165                 170                 175     


Asn Phe Leu Glu Thr Ser Leu Glu Ala Lys Asn Ala Cys Val Leu Leu 
            180                 185                 190         


Ser Gln Ser Arg Leu Phe Glu Glu Pro Glu Leu Thr Gln Arg Cys Trp 
        195                 200                 205             


Glu Val Ile Asp Ala Gln Ala Glu Met Ala Leu Arg Ser Glu Gly Phe 
    210                 215                 220                 


Cys Glu Ile Asp Arg Gln Thr Leu Glu Ile Ile Val Thr Arg Glu Ala 
225                 230                 235                 240 


Leu Asn Thr Lys Glu Ala Val Val Phe Glu Ala Val Leu Asn Trp Ala 
                245                 250                 255     


Glu Ala Glu Cys Lys Arg Gln Gly Leu Pro Ile Thr Pro Arg Asn Lys 
            260                 265                 270         


Arg His Val Leu Gly Arg Ala Leu Tyr Leu Val Arg Ile Pro Thr Met 
        275                 280                 285             


Thr Leu Glu Glu Phe Ala Asn Gly Ala Ala Gln Ser Asp Ile Leu Thr 
    290                 295                 300                 


Leu Glu Glu Thr His Ser Ile Phe Leu Trp Tyr Thr Ala Thr Asn Lys 
305                 310                 315                 320 


Pro Arg Leu Asp Phe Pro Leu Thr Lys Arg Lys Gly Leu Ala Pro Gln 
                325                 330                 335     


Arg Cys His Arg Phe Gln Ser Ser Ala Tyr Arg Ser Asn Gln Trp Arg 
            340                 345                 350         


Tyr Arg Gly Arg Cys Asp Ser Ile Gln Phe Ala Val Asp Arg Arg Val 
        355                 360                 365             


Phe Ile Ala Gly Leu Gly Leu Tyr Gly Ser Ser Ser Gly Lys Ala Glu 
    370                 375                 380                 


Tyr Ser Val Lys Ile Glu Leu Lys Arg Leu Gly Val Val Leu Ala Gln 
385                 390                 395                 400 


Asn Leu Thr Lys Phe Met Ser 
                405         


<210> 8751
<211> 200
<212> PRT
<213> Homo sapiens

<400> 8751
Met Leu Glu Leu Val Ala Gln Lys Gln Arg Glu Arg Glu Glu Arg Glu 
1               5                   10                  15      


Glu Arg Glu Ala Leu Glu Arg Glu Arg Gln Arg Arg Arg Gln Gly Gln 
            20                  25                  30          


Glu Leu Ser Ala Ala Arg Gln Arg Leu Gln Glu Asp Glu Met Arg Arg 
        35                  40                  45              


Ala Ala Glu Glu Arg Arg Arg Glu Lys Ala Glu Glu Leu Ala Ala Arg 
    50                  55                  60                  


Gln Arg Val Arg Glu Lys Ile Glu Arg Asp Lys Ala Glu Arg Ala Lys 
65                  70                  75                  80  


Lys Tyr Gly Gly Ser Val Gly Ser Gln Pro Pro Pro Val Ala Pro Glu 
                85                  90                  95      


Pro Gly Pro Val Pro Ser Ser Pro Ser Gln Glu Pro Pro Thr Lys Arg 
            100                 105                 110         


Glu Tyr Asp Gln Cys Arg Ile Gln Val Arg Leu Pro Asp Gly Thr Ser 
        115                 120                 125             


Leu Thr Gln Thr Phe Arg Ala Arg Glu Gln Leu Ala Ala Val Arg Leu 
    130                 135                 140                 


Tyr Val Glu Leu His Arg Gly Glu Glu Leu Gly Gly Gly Gln Asp Pro 
145                 150                 155                 160 


Val Gln Leu Leu Ser Gly Phe Pro Arg Arg Ala Phe Ser Glu Ala Asp 
                165                 170                 175     


Met Glu Arg Pro Leu Gln Glu Leu Gly Leu Val Pro Ser Ala Val Leu 
            180                 185                 190         


Ile Val Ala Lys Lys Cys Pro Ser 
        195                 200 


<210> 8752
<211> 294
<212> PRT
<213> Homo sapiens

<400> 8752
Met Gly Leu Ala Ser Trp Ser Gln Leu Ala Ser Thr Pro Arg Ala Pro 
1               5                   10                  15      


Gly Ser Arg Asp Ala Arg Trp Glu Arg Arg Glu Pro Ala Leu Arg Gly 
            20                  25                  30          


Ala Lys Asp Arg Leu Thr Ile Gly Lys His Leu Asp Met Gly Ser Pro 
        35                  40                  45              


Gln Leu Arg Thr Arg Asp Arg Gly Trp Pro Ser Pro Arg Pro Glu Arg 
    50                  55                  60                  


Glu Lys Arg Thr Ser Gln Ser Ala Arg Arg Pro Thr Cys Thr Glu Ser 
65                  70                  75                  80  


Arg Trp Lys Ser Glu Glu Glu Val Glu Ser Asp Asp Glu Tyr Leu Ala 
                85                  90                  95      


Leu Pro Ala Arg Leu Thr Gln Val Ser Ser Leu Val Ser Tyr Leu Gly 
            100                 105                 110         


Ser Ile Ser Thr Leu Val Thr Leu Pro Thr Gly Asp Ile Lys Gly Gln 
        115                 120                 125             


Ser Pro Leu Glu Val Ser Asp Ser Asp Gly Pro Ala Ser Phe Pro Ser 
    130                 135                 140                 


Ser Ser Ser Gln Ser Gln Leu Pro Pro Gly Ala Ala Leu Gln Gly Ser 
145                 150                 155                 160 


Gly Asp Pro Glu Gly Gln Asn Pro Cys Phe Leu Arg Ser Phe Val Arg 
                165                 170                 175     


Ala His Asp Ser Ala Gly Glu Gly Ser Leu Gly Ser Ser Gln Ala Leu 
            180                 185                 190         


Gly Val Ser Ser Gly Leu Leu Lys Thr Arg Pro Ser Leu Pro Ala Arg 
        195                 200                 205             


Leu Asp Arg Trp Pro Phe Ser Asp Pro Asp Val Glu Gly Gln Leu Pro 
    210                 215                 220                 


Arg Lys Gly Gly Glu Gln Gly Lys Glu Ser Leu Val Gln Cys Val Lys 
225                 230                 235                 240 


Val Met Thr Leu Asn Val Arg Lys Leu Cys Val Gln Val Ser Cys Leu 
                245                 250                 255     


Phe Pro Gln Ser Thr Asn Ile Ile Ile Lys His Val His Val Asp Gln 
            260                 265                 270         


Ala Leu Phe Met Cys Gln Ala Leu Cys Cys Thr Leu Ser Tyr Ser Val 
        275                 280                 285             


Leu Thr Thr Phe Thr Arg 
    290                 


<210> 8753
<211> 117
<212> PRT
<213> Homo sapiens

<400> 8753
Met Val Arg Lys Ile Thr Leu Val Ser Ala Ala Pro Gly Lys Val Ile 
1               5                   10                  15      


Cys Glu Met Lys Val Glu Glu Glu His Thr Asn Ala Ile Gly Thr Leu 
            20                  25                  30          


His Gly Gly Leu Thr Ala Thr Leu Val Asp Asn Ile Ser Thr Met Ala 
        35                  40                  45              


Leu Leu Cys Thr Glu Arg Gly Ala Pro Gly Val Ser Val Asp Met Asn 
    50                  55                  60                  


Ile Thr Tyr Met Ser Pro Ala Lys Leu Gly Glu Asp Ile Val Ile Thr 
65                  70                  75                  80  


Ala His Val Leu Lys Gln Gly Lys Thr Leu Ala Phe Thr Ser Val Asp 
                85                  90                  95      


Leu Thr Asn Lys Ala Thr Gly Lys Leu Ile Ala Gln Gly Arg His Thr 
            100                 105                 110         


Lys His Leu Gly Asn 
        115         


<210> 8754
<211> 279
<212> PRT
<213> Homo sapiens

<400> 8754
Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile Phe Gly 
1               5                   10                  15      


Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln Gly Lys 
            20                  25                  30          


Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn Ala Lys 
        35                  40                  45              


Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys Lys Phe 
    50                  55                  60                  


Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg Lys Thr 
65                  70                  75                  80  


Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala Gly Glu 
                85                  90                  95      


Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe Val Met 
            100                 105                 110         


Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe Leu Gln 
        115                 120                 125             


Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu Pro Ile 
    130                 135                 140                 


Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu Asn Phe 
145                 150                 155                 160 


Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu Phe Tyr 
                165                 170                 175     


Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr Lys Glu 
            180                 185                 190         


Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala Lys Met 
        195                 200                 205             


Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg Gly Phe 
    210                 215                 220                 


Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro Lys Lys 
225                 230                 235                 240 


Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu Gln Arg 
                245                 250                 255     


Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys Lys Lys 
            260                 265                 270         


Lys Lys Ala Gln Glu Asp Leu 
        275                 


<210> 8755
<211> 1075
<212> PRT
<213> Homo sapiens

<400> 8755
Met Ser Gln Gly Phe His Pro Glu Arg Asp Pro Ser Asp Leu Lys Lys 
1               5                   10                  15      


Val Lys Ala Val Glu Glu Asn Gly Glu Glu Ala Glu Pro Val Arg Asn 
            20                  25                  30          


Gly Ala Glu Ser Val Ser Glu Gly Glu Gly Ile Asp Ala Asn Ser Gly 
        35                  40                  45              


Ser Thr Asp Ser Ser Gly Asp Gly Val Thr Phe Pro Phe Lys Pro Glu 
    50                  55                  60                  


Ser Trp Lys Pro Thr Asp Thr Glu Gly Lys Lys Gln Tyr Asp Arg Glu 
65                  70                  75                  80  


Phe Leu Leu Asp Phe Gln Phe Met Pro Ala Cys Ile Gln Lys Pro Glu 
                85                  90                  95      


Gly Leu Pro Pro Ile Ser Asp Val Val Leu Asp Lys Ile Asn Gln Pro 
            100                 105                 110         


Lys Leu Pro Met Arg Thr Leu Asp Pro Arg Ile Leu Pro Arg Gly Pro 
        115                 120                 125             


Asp Phe Thr Pro Ala Phe Ala Asp Phe Gly Arg Gln Thr Pro Gly Gly 
    130                 135                 140                 


Arg Gly Val Pro Ile Cys Lys Val Gln Ser Arg His Gly Leu Pro Ile 
145                 150                 155                 160 


Leu Glu Gln Ser Lys Ala Pro Thr Cys Pro Pro Leu Val Met Ser His 
                165                 170                 175     


Pro Pro Met Lys Ser Leu Pro Leu Gly Leu Leu Asn Val Gly Ser Arg 
            180                 185                 190         


Arg Ser Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys Ile Ile Thr Val 
        195                 200                 205             


Ser Val Lys Glu Asp Val His Leu Lys Lys Ala Glu Asn Ala Trp Lys 
    210                 215                 220                 


Pro Ser Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro Glu Asn Ile Lys 
225                 230                 235                 240 


Thr Gln Glu Leu Phe Arg Lys Val Arg Ser Ile Leu Asn Lys Leu Thr 
                245                 250                 255     


Pro Gln Met Phe Asn Gln Leu Met Lys Gln Val Ser Gly Leu Thr Val 
            260                 265                 270         


Asp Thr Glu Glu Arg Leu Lys Gly Val Ile Asp Leu Val Phe Glu Lys 
        275                 280                 285             


Ala Ile Asp Glu Pro Ser Phe Ser Val Ala Tyr Ala Asn Met Cys Arg 
    290                 295                 300                 


Cys Leu Val Thr Leu Lys Val Pro Met Ala Asp Lys Pro Gly Asn Thr 
305                 310                 315                 320 


Val Asn Phe Arg Lys Leu Leu Leu Asn Arg Cys Gln Lys Glu Phe Glu 
                325                 330                 335     


Lys Asp Lys Ala Asp Asp Asp Val Phe Glu Lys Lys Gln Lys Glu Leu 
            340                 345                 350         


Glu Ala Ala Ser Ala Pro Glu Glu Arg Thr Arg Leu His Asp Glu Leu 
        355                 360                 365             


Glu Glu Ala Lys Asp Lys Ala Arg Arg Arg Ser Ile Gly Asn Ile Lys 
    370                 375                 380                 


Phe Ile Gly Glu Leu Phe Lys Leu Lys Met Leu Thr Glu Ala Ile Met 
385                 390                 395                 400 


His Asp Cys Val Val Lys Leu Leu Lys Asn His Asp Glu Glu Ser Leu 
                405                 410                 415     


Glu Cys Leu Cys Arg Leu Leu Thr Thr Ile Gly Lys Asp Leu Asp Phe 
            420                 425                 430         


Glu Lys Ala Lys Pro Arg Met Asp Gln Tyr Phe Asn Gln Met Glu Lys 
        435                 440                 445             


Ile Val Lys Glu Arg Lys Thr Ser Ser Arg Ile Arg Phe Met Leu Gln 
    450                 455                 460                 


Asp Val Ile Asp Leu Arg Leu Cys Asn Trp Val Ser Arg Arg Ala Asp 
465                 470                 475                 480 


Gln Gly Pro Lys Thr Ile Glu Gln Ile His Lys Glu Ala Lys Ile Glu 
                485                 490                 495     


Glu Gln Glu Glu Gln Arg Lys Val Gln Gln Leu Met Thr Lys Glu Lys 
            500                 505                 510         


Arg Arg Pro Gly Val Gln Arg Val Asp Glu Gly Gly Trp Asn Thr Val 
        515                 520                 525             


Gln Gly Ala Lys Asn Ser Arg Val Leu Asp Pro Ser Lys Phe Leu Lys 
    530                 535                 540                 


Ile Thr Lys Pro Thr Ile Asp Glu Lys Ile Gln Leu Val Pro Lys Ala 
545                 550                 555                 560 


Gln Leu Gly Ser Trp Gly Lys Gly Ser Ser Gly Gly Ala Lys Ala Ser 
                565                 570                 575     


Glu Thr Asp Ala Leu Arg Ser Ser Ala Ser Ser Leu Asn Arg Phe Ser 
            580                 585                 590         


Ala Leu Gln Pro Pro Ala Pro Ser Gly Ser Thr Pro Ser Thr Pro Val 
        595                 600                 605             


Glu Phe Asp Ser Arg Arg Thr Leu Thr Ser Arg Gly Ser Met Gly Arg 
    610                 615                 620                 


Glu Lys Asn Asp Lys Pro Leu Pro Ser Ala Thr Ala Arg Pro Asn Thr 
625                 630                 635                 640 


Phe Met Arg Gly Gly Ser Ser Lys Asp Leu Leu Asp Asn Gln Ser Gln 
                645                 650                 655     


Glu Glu Gln Arg Arg Glu Met Leu Glu Thr Val Lys Gln Leu Thr Gly 
            660                 665                 670         


Gly Val Asp Val Glu Arg Asn Ser Thr Glu Ala Glu Arg Asn Lys Thr 
        675                 680                 685             


Arg Glu Ser Ala Lys Pro Glu Ile Ser Ala Met Ser Ala His Asp Lys 
    690                 695                 700                 


Ala Ala Leu Ser Glu Glu Glu Leu Glu Arg Lys Ser Lys Ser Ile Ile 
705                 710                 715                 720 


Asp Glu Phe Leu His Ile Asn Asp Phe Lys Glu Ala Met Gln Cys Val 
                725                 730                 735     


Glu Glu Leu Asn Ala Gln Gly Leu Leu His Val Phe Val Arg Val Gly 
            740                 745                 750         


Val Glu Ser Thr Leu Glu Arg Ser Gln Ile Thr Arg Asp His Met Gly 
        755                 760                 765             


Gln Leu Leu Tyr Gln Leu Val Gln Ser Glu Lys Leu Ser Lys Gln Asp 
    770                 775                 780                 


Phe Phe Lys Gly Phe Ser Glu Thr Leu Glu Leu Ala Asp Asp Met Ala 
785                 790                 795                 800 


Ile Asp Ile Pro His Ile Trp Leu Tyr Leu Ala Glu Leu Val Thr Pro 
                805                 810                 815     


Met Leu Lys Glu Gly Gly Ile Ser Met Arg Glu Leu Thr Ile Glu Phe 
            820                 825                 830         


Ser Lys Pro Leu Leu Pro Val Gly Arg Ala Gly Val Leu Leu Ser Glu 
        835                 840                 845             


Ile Leu His Leu Leu Cys Lys Gln Met Ser His Lys Lys Val Gly Ala 
    850                 855                 860                 


Leu Trp Arg Glu Ala Asp Leu Ser Trp Lys Asp Phe Leu Pro Glu Gly 
865                 870                 875                 880 


Glu Asp Val His Asn Phe Leu Leu Glu Gln Lys Leu Asp Phe Ile Glu 
                885                 890                 895     


Ser Asp Ser Pro Cys Ser Ser Glu Ala Leu Ser Lys Lys Glu Leu Ser 
            900                 905                 910         


Ala Glu Glu Leu Tyr Lys Arg Leu Glu Lys Leu Ile Ile Glu Asp Lys 
        915                 920                 925             


Ala Asn Asp Glu Gln Ile Phe Asp Trp Val Glu Ala Asn Leu Asp Glu 
    930                 935                 940                 


Ile Gln Met Ser Ser Pro Thr Phe Leu Arg Ala Leu Met Thr Ala Val 
945                 950                 955                 960 


Cys Lys Ala Ala Ile Ile Ala Asp Ser Ser Thr Phe Arg Val Asp Thr 
                965                 970                 975     


Ala Val Ile Lys Gln Arg Val Pro Ile Leu Leu Lys Tyr Leu Asp Ser 
            980                 985                 990         


Asp Thr Glu Lys Glu Leu Gln Ala  Leu Tyr Ala Leu Gln  Ala Ser Ile 
        995                 1000                 1005             


Val Lys  Leu Asp Gln Pro Ala  Asn Leu Leu Arg Met  Phe Phe Asp 
    1010                 1015                 1020             


Cys Leu  Tyr Asp Glu Glu Val  Ile Ser Glu Asp Ala  Phe Tyr Lys 
    1025                 1030                 1035             


Trp Glu  Ser Ser Lys Asp Pro  Ala Glu Gln Asn Gly  Lys Gly Val 
    1040                 1045                 1050             


Ala Leu  Lys Ser Val Thr Ala  Phe Phe Thr Trp Leu  Arg Glu Ala 
    1055                 1060                 1065             


Glu Glu  Glu Ser Glu Asp Asn  
    1070                 1075 


<210> 8756
<211> 157
<212> PRT
<213> Homo sapiens

<400> 8756
Met Lys Cys Ile Pro Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg 
1               5                   10                  15      


Asn Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu Ala Val Tyr Thr Asp 
            20                  25                  30          


Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp 
        35                  40                  45              


Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val 
    50                  55                  60                  


Lys Thr Leu His Glu Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly 
65                  70                  75                  80  


Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn 
                85                  90                  95      


Arg Thr Gln Gln Gln Val Glu Ala Glu Val Thr Asn Ile Lys Lys Thr 
            100                 105                 110         


Leu Lys Ala Thr Ala Ser Ser Ser Ala Gln Glu Met Glu Gln Gln Leu 
        115                 120                 125             


Ala Glu Arg Glu Cys Pro Pro His Ala Glu Gln Arg Gln Pro Thr Lys 
    130                 135                 140                 


Lys Met Ser Lys Val Lys Gly Leu Val Ser Ser Arg His 
145                 150                 155         


<210> 8757
<211> 278
<212> PRT
<213> Homo sapiens

<400> 8757
Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe 
1               5                   10                  15      


Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser 
            20                  25                  30          


Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu 
        35                  40                  45              


Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr 
    50                  55                  60                  


Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg 
65                  70                  75                  80  


Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly 
            100                 105                 110         


Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln 
        115                 120                 125             


Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu Thr Leu Ser 
    130                 135                 140                 


Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val Gly Ser Val 
145                 150                 155                 160 


Ile Thr Lys Lys Leu Glu Asp Val Lys Asn Ser Pro Thr Phe Lys Ser 
                165                 170                 175     


Phe Glu Glu Lys Val Glu Asn Leu Lys Gly Ser Pro Lys Asn Val Glu 
            180                 185                 190         


Ser Phe Ala Ser Met Leu Arg His Ser Pro Leu Thr Gln Met Gly Pro 
        195                 200                 205             


Ala Lys Asp Lys Leu Val Ile Gly Arg Ile Phe His Ile Val Glu Asn 
    210                 215                 220                 


Asp Leu Tyr Ile Asp Phe Gly Gly Lys Phe His Cys Val Cys Arg Arg 
225                 230                 235                 240 


Pro Glu Val Asp Gly Glu Ser Pro Ile Ser Trp Tyr Ala Val Trp Arg 
                245                 250                 255     


Arg Phe Ser Gln Val Met Ile Thr Cys Phe Ser Ser Asn Ser Asp Phe 
            260                 265                 270         


Gly Lys His Arg Lys Arg 
        275             


<210> 8758
<211> 1040
<212> PRT
<213> Homo sapiens

<400> 8758
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg 
            100                 105                 110         


Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys 
        115                 120                 125             


Thr Glu Ala Gln Asp Lys Asp Asn Arg Cys Arg Tyr Ile Leu Lys Thr 
    130                 135                 140                 


Lys Phe Arg Glu Met Trp Lys Ser Trp Pro Gly Asp Ser Lys Glu Val 
145                 150                 155                 160 


Gln Val Met Ala Glu Arg Tyr Lys Met Leu Ile Pro Phe Ser Asn Pro 
                165                 170                 175     


Arg Val Leu Pro Gly Pro Phe Ser Tyr Thr Val Val Leu Tyr Gly Pro 
            180                 185                 190         


Ala Gly Leu Gly Lys Thr Thr Leu Ala Gln Lys Leu Met Leu Asp Trp 
        195                 200                 205             


Ala Glu Asp Asn Leu Ile His Lys Phe Lys Tyr Ala Phe Tyr Leu Ser 
    210                 215                 220                 


Cys Arg Glu Leu Ser Arg Leu Gly Pro Cys Ser Phe Ala Glu Leu Val 
225                 230                 235                 240 


Phe Arg Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro His Ile Leu Ala 
                245                 250                 255     


Gln Ala Arg Lys Ile Leu Phe Val Ile Asp Gly Phe Asp Glu Leu Gly 
            260                 265                 270         


Ala Ala Pro Gly Ala Leu Ile Glu Asp Ile Cys Gly Asp Trp Glu Lys 
        275                 280                 285             


Lys Lys Pro Val Pro Val Leu Leu Gly Ser Leu Leu Asn Arg Val Met 
    290                 295                 300                 


Leu Pro Lys Ala Ala Leu Leu Val Thr Thr Arg Pro Arg Ala Leu Arg 
305                 310                 315                 320 


Asp Leu Arg Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val Glu Gly 
                325                 330                 335     


Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His Phe Gly Asp 
            340                 345                 350         


Glu Asp Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser Asn Ala Ala 
        355                 360                 365             


Leu Phe Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile Val Cys Thr 
    370                 375                 380                 


Thr Leu Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val Pro Thr Cys 
385                 390                 395                 400 


Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser Arg Phe Pro 
                405                 410                 415     


Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser Leu Leu Ala 
            420                 425                 430         


Ala Gln Gly Leu Trp Ala Gln Thr Ser Val Leu His Arg Glu Asp Leu 
        435                 440                 445             


Glu Arg Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe Leu Asp Gly 
    450                 455                 460                 


Asp Ile Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr Ser Phe Ile 
465                 470                 475                 480 


His Leu Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr Thr Leu Glu 
                485                 490                 495     


Lys Glu Glu Glu Glu Asp Arg Asp Gly His Thr Trp Asp Ile Gly Asp 
            500                 505                 510         


Val Gln Lys Leu Leu Ser Gly Val Glu Arg Leu Arg Asn Pro Asp Leu 
        515                 520                 525             


Ile Gln Ala Gly Tyr Tyr Ser Phe Gly Leu Ala Asn Glu Lys Arg Ala 
    530                 535                 540                 


Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro Asp Ile Lys 
545                 550                 555                 560 


Gln Glu Leu Leu Arg Cys Asp Ile Ser Cys Lys Gly Gly His Ser Thr 
                565                 570                 575     


Val Thr Asp Leu Gln Glu Leu Leu Gly Cys Leu Tyr Glu Ser Gln Glu 
            580                 585                 590         


Glu Glu Leu Val Lys Glu Val Met Ala Gln Phe Lys Glu Ile Ser Leu 
        595                 600                 605             


His Leu Asn Ala Val Asp Val Val Pro Ser Ser Phe Cys Val Lys His 
    610                 615                 620                 


Cys Arg Asn Leu Gln Lys Met Ser Leu Gln Val Ile Lys Glu Asn Leu 
625                 630                 635                 640 


Pro Glu Asn Val Thr Ala Ser Glu Ser Asp Ala Glu Val Glu Arg Ser 
                645                 650                 655     


Gln Asp Asp Gln His Met Leu Pro Phe Trp Thr Asp Leu Cys Ser Ile 
            660                 665                 670         


Phe Gly Ser Asn Lys Asp Leu Met Gly Leu Ala Ile Asn Asp Ser Phe 
        675                 680                 685             


Leu Ser Ala Ser Leu Val Arg Ile Leu Cys Glu Gln Ile Ala Ser Asp 
    690                 695                 700                 


Thr Cys His Leu Gln Arg Val Val Phe Lys Asn Ile Ser Pro Ala Asp 
705                 710                 715                 720 


Ala His Arg Asn Leu Cys Leu Ala Leu Arg Gly His Lys Thr Val Thr 
                725                 730                 735     


Tyr Leu Thr Leu Gln Gly Asn Asp Gln Asp Asp Met Phe Pro Ala Leu 
            740                 745                 750         


Cys Glu Val Leu Arg His Pro Glu Cys Asn Leu Arg Tyr Leu Gly Leu 
        755                 760                 765             


Val Ser Cys Ser Ala Thr Thr Gln Gln Trp Ala Asp Leu Ser Leu Ala 
    770                 775                 780                 


Leu Glu Val Asn Gln Ser Leu Thr Cys Val Asn Leu Ser Asp Asn Glu 
785                 790                 795                 800 


Leu Leu Asp Glu Gly Ala Lys Leu Leu Tyr Thr Thr Leu Arg His Pro 
                805                 810                 815     


Lys Cys Phe Leu Gln Arg Leu Ser Leu Glu Asn Cys His Leu Thr Glu 
            820                 825                 830         


Ala Asn Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Arg Glu Leu 
        835                 840                 845             


Thr His Leu Cys Leu Ala Lys Asn Pro Ile Gly Asn Thr Gly Val Lys 
    850                 855                 860                 


Phe Leu Cys Glu Gly Leu Arg Tyr Pro Glu Cys Lys Leu Gln Thr Leu 
865                 870                 875                 880 


Val Leu Trp Asn Cys Asp Ile Thr Ser Asp Gly Cys Cys Asp Leu Thr 
                885                 890                 895     


Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu Cys Leu Asp Leu Gly Leu 
            900                 905                 910         


Asn His Ile Gly Val Lys Gly Met Lys Phe Leu Cys Glu Ala Leu Arg 
        915                 920                 925             


Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp Leu Trp Gly Cys Ser Ile 
    930                 935                 940                 


Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser Ala Leu Ser Cys Asn Gln 
945                 950                 955                 960 


Ser Leu Val Thr Leu Asp Leu Gly Gln Asn Pro Leu Gly Ser Ser Gly 
                965                 970                 975     


Val Lys Met Leu Phe Glu Thr Leu Thr Cys Ser Ser Gly Thr Leu Arg 
            980                 985                 990         


Thr Leu Arg Leu Lys Ile Asp Asp  Phe Asn Asp Glu Leu  Asn Lys Leu 
        995                 1000                 1005             


Leu Glu  Glu Ile Glu Glu Lys  Asn Pro Gln Leu Ile  Ile Asp Thr 
    1010                 1015                 1020             


Glu Lys  His His Pro Trp Ala  Glu Arg Pro Ser Ser  His Asp Phe 
    1025                 1030                 1035             


Met Ile  
    1040 


<210> 8759
<211> 602
<212> PRT
<213> Homo sapiens

<400> 8759
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Arg Arg Leu His Lys Leu Gly 
            100                 105                 110         


Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu Val Val Ser 
        115                 120                 125             


Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln Ser Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val Gly Gln Asp Ser 
145                 150                 155                 160 


Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys Glu Ala Pro Pro 
                165                 170                 175     


Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu 
            180                 185                 190         


Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu Arg Ala Leu 
        195                 200                 205             


Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg Glu Leu Glu 
    210                 215                 220                 


Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser Phe Asn Arg 
225                 230                 235                 240 


Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val Thr Cys Met 
                245                 250                 255     


Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser Tyr Asn Asn 
            260                 265                 270         


Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn 
        275                 280                 285             


Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser 
    290                 295                 300                 


Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn Leu Val Val 
305                 310                 315                 320 


Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser His 
                325                 330                 335     


Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr 
            340                 345                 350         


His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn 
        355                 360                 365             


Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp Ser Leu Asp 
    370                 375                 380                 


Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr Asn Lys Ser 
385                 390                 395                 400 


Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly Asp Val Asn 
                405                 410                 415     


Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr Ala Cys Arg 
            420                 425                 430         


His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly His Gln Gly 
        435                 440                 445             


Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro Ile Asp Phe 
    450                 455                 460                 


Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp 
465                 470                 475                 480 


Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp 
                485                 490                 495     


Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala Leu Phe Ala 
            500                 505                 510         


Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp 
        515                 520                 525             


Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala Ser Ala Leu 
    530                 535                 540                 


Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val Ala Val Gly Asp 
545                 550                 555                 560 


Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu Gly Leu Ala Met 
                565                 570                 575     


Leu Pro Gly Trp Ser Gln Asn Ser Trp Thr Gln Ala Ile Leu Leu Cys 
            580                 585                 590         


Trp Pro Pro Lys Val Leu Gly Leu Gln Thr 
        595                 600         


<210> 8760
<211> 948
<212> PRT
<213> Homo sapiens

<400> 8760
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Ile Gly Gln Val Lys Gln Glu Leu Ser 
        435                 440                 445             


Arg Lys Asp Thr Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu 
    450                 455                 460                 


Thr Asn Gln Phe Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Thr Ala Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val 
                485                 490                 495     


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
            500                 505                 510         


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
        515                 520                 525             


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
    530                 535                 540                 


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
545                 550                 555                 560 


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
                565                 570                 575     


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
            580                 585                 590         


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
        595                 600                 605             


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
    610                 615                 620                 


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
625                 630                 635                 640 


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
                645                 650                 655     


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
            660                 665                 670         


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
        675                 680                 685             


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
    690                 695                 700                 


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
705                 710                 715                 720 


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
                725                 730                 735     


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
            740                 745                 750         


Glu Leu Glu Ser Leu Phe Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
        755                 760                 765             


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
    770                 775                 780                 


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
785                 790                 795                 800 


Ser Gln Gln Leu Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val 
                805                 810                 815     


Lys Gln Glu Leu Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln 
            820                 825                 830         


Ser Leu Ala Glu Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg 
        835                 840                 845             


Arg Lys His Leu Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu 
    850                 855                 860                 


Ala Ala Ile Ser Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser 
865                 870                 875                 880 


Ser Ser Lys Lys Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu 
                885                 890                 895     


Lys Asp Arg Leu Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met 
            900                 905                 910         


Lys Leu Met Ala Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His 
        915                 920                 925             


Ser Asn Gln Thr Asn His Lys Pro Ser Pro Asp Gln Asp Glu Glu Glu 
    930                 935                 940                 


Gly Ile Trp Ala 
945             


<210> 8761
<211> 913
<212> PRT
<213> Homo sapiens

<400> 8761
Met Glu Val Gly Ser Glu Glu Glu Lys Trp Glu Lys Leu Asp Ala Glu 
1               5                   10                  15      


Phe Asp His Phe Val Val Asp Met Lys Pro Phe Val Leu Lys Leu Pro 
            20                  25                  30          


His Arg Thr Glu Arg Gln Arg Cys Ala Leu Trp Ile Arg Lys Leu Cys 
        35                  40                  45              


Glu Pro Ser Gly Thr Gly Ala Gly Ile Met Gly Arg Lys Asn Arg Asn 
    50                  55                  60                  


Leu Tyr Ala Lys Leu Leu Leu His Met Leu Lys Arg Gly Ala Leu Glu 
65                  70                  75                  80  


Gly Pro Phe Thr His Arg Pro Glu Pro Gly Thr Leu Lys Ile Leu Pro 
                85                  90                  95      


Ser Tyr Met Ser Ile Tyr Phe Asp Glu Pro Asn Pro Ala Arg Ala Lys 
            100                 105                 110         


Gly Ser Ser Pro Glu Gly Leu Pro Ala Trp Val Leu Gly Glu Leu Glu 
        115                 120                 125             


Thr Ser Glu His Lys Leu Asn Glu Ser Trp Lys Leu Ser Ser Gly Glu 
    130                 135                 140                 


Asp Asn Thr Leu Val Gln Ser Pro Thr Asp Val Tyr Ser Arg Glu Gln 
145                 150                 155                 160 


Tyr Thr Gly Lys Leu Arg Val Arg Ser His Ser Leu Ser Pro Thr His 
                165                 170                 175     


Arg Glu Asp Gly Gln Asn Ile Thr Pro Lys Ile Cys Glu Val Tyr Ser 
            180                 185                 190         


Lys Lys Ser Pro Val Ser Leu Asp Asp Ser Asp Ile Glu Ala Arg Leu 
        195                 200                 205             


Asn Ser Trp Asn Leu Gly Leu Asp Met Lys Thr Lys Met Met Glu Ala 
    210                 215                 220                 


Lys Phe His Glu Glu Lys Leu Lys Leu Gln Gln Lys His Asp Ala Asp 
225                 230                 235                 240 


Val Gln Lys Ile Leu Glu Arg Lys Asn Asn Glu Ile Glu Glu Leu Lys 
                245                 250                 255     


Thr Leu Tyr Arg Ser Lys Gln His Glu Thr Glu Glu Thr Ile Arg Lys 
            260                 265                 270         


Leu Glu Lys Lys Val Gln Thr Leu Ile Arg Asp Cys Gln Val Ile Arg 
        275                 280                 285             


Glu Thr Lys Glu Asp Gln Ile Ala Glu Leu Lys Lys Ile Cys Glu Gln 
    290                 295                 300                 


Ser Thr Glu Ser Leu Asn Asn Asp Trp Glu Lys Lys Leu His Asn Ala 
305                 310                 315                 320 


Val Ala Glu Met Glu Gln Glu Lys Phe Asp Leu Gln Lys Gln His Thr 
                325                 330                 335     


Glu Asn Ile Gln Glu Leu Leu Glu Asp Thr Asn Val Arg Leu Asn Lys 
            340                 345                 350         


Met Glu Ser Glu Tyr Met Ala Gln Thr Gln Ser Thr Asn His Met Ile 
        355                 360                 365             


Lys Glu Leu Glu Ala Arg Val Gln Gln Leu Thr Gly Glu Ala Glu Asn 
    370                 375                 380                 


Ser Asn Leu Gln Arg Gln Lys Leu Ile Gln Glu Lys Ala Glu Leu Glu 
385                 390                 395                 400 


Arg Cys Tyr Gln Ile Thr Cys Ser Glu Leu Gln Glu Val Lys Ala Arg 
                405                 410                 415     


Arg Asn Thr Leu His Lys Glu Lys Asp His Leu Val Asn Asp Tyr Glu 
            420                 425                 430         


Gln Asn Met Lys Leu Leu Gln Thr Lys Tyr Asp Ala Asp Ile Asn Leu 
        435                 440                 445             


Leu Lys Gln Glu His Ala Leu Ser Ala Ser Lys Ala Ser Ser Met Ile 
    450                 455                 460                 


Glu Glu Leu Glu Gln Asn Val Cys Gln Leu Lys Gln Gln Leu Gln Glu 
465                 470                 475                 480 


Ser Glu Leu Gln Arg Lys Gln Gln Leu Arg Asp Gln Glu Asn Lys Phe 
                485                 490                 495     


Gln Met Glu Lys Ser His Leu Lys His Ile Tyr Glu Lys Lys Ala His 
            500                 505                 510         


Asp Leu Gln Ser Glu Leu Asp Lys Gly Lys Glu Asp Thr Gln Lys Lys 
        515                 520                 525             


Ile His Lys Phe Glu Glu Ala Leu Lys Glu Lys Glu Glu Gln Leu Thr 
    530                 535                 540                 


Arg Val Thr Glu Val Gln Arg Leu Gln Ala Gln Gln Ala Asp Ala Ala 
545                 550                 555                 560 


Leu Glu Glu Phe Lys Arg Gln Val Glu Leu Asn Ser Glu Lys Val Tyr 
                565                 570                 575     


Ala Glu Met Lys Glu Gln Met Glu Lys Val Glu Ala Asp Leu Thr Arg 
            580                 585                 590         


Ser Lys Ser Leu Arg Glu Lys Gln Ser Lys Glu Phe Leu Trp Gln Leu 
        595                 600                 605             


Glu Asp Ile Arg Gln Arg Tyr Glu Gln Gln Ile Val Glu Leu Lys Leu 
    610                 615                 620                 


Glu His Glu Gln Glu Lys Thr His Leu Leu Gln Gln His Asn Ala Glu 
625                 630                 635                 640 


Lys Asp Ser Leu Val Arg Asp His Glu Arg Glu Ile Glu Asn Leu Glu 
                645                 650                 655     


Lys Gln Leu Arg Ala Ala Asn Met Glu His Glu Asn Gln Ile Gln Glu 
            660                 665                 670         


Phe Lys Lys Arg Asp Ala Gln Val Ile Ala Asp Met Glu Ala Gln Val 
        675                 680                 685             


His Lys Leu Arg Glu Glu Leu Ile Asn Val Asn Ser Gln Arg Lys Gln 
    690                 695                 700                 


Gln Leu Val Glu Leu Gly Leu Leu Arg Glu Glu Glu Lys Gln Arg Ala 
705                 710                 715                 720 


Thr Arg Glu His Glu Ile Val Val Asn Lys Leu Lys Ala Glu Ser Glu 
                725                 730                 735     


Lys Met Lys Ile Glu Leu Lys Lys Thr His Ala Ala Glu Thr Glu Met 
            740                 745                 750         


Thr Leu Glu Lys Ala Asn Ser Lys Leu Lys Gln Ile Glu Lys Glu Tyr 
        755                 760                 765             


Thr Gln Lys Leu Ala Lys Ser Ser Gln Ile Ile Ala Glu Leu Gln Thr 
    770                 775                 780                 


Thr Ile Ser Ser Leu Lys Glu Glu Asn Ser Gln Gln Gln Leu Ala Ala 
785                 790                 795                 800 


Glu Arg Arg Leu Gln Asp Val Arg Gln Lys Phe Glu Asp Glu Lys Lys 
                805                 810                 815     


Gln Leu Ile Arg Asp Asn Asp Gln Ala Ile Lys Val Leu Gln Asp Glu 
            820                 825                 830         


Leu Glu Asn Arg Ser Asn Gln Val Arg Cys Ala Glu Lys Lys Leu Gln 
        835                 840                 845             


His Lys Glu Leu Glu Ser Gln Glu Gln Ile Thr Tyr Ile Arg Gln Glu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Lys Gly Leu Met Pro Ala Ser Leu Arg Gln Glu 
865                 870                 875                 880 


Leu Glu Asp Thr Ile Ser Ser Leu Lys Ser Gln Val Asn Phe Leu Gln 
                885                 890                 895     


Lys Arg Ala Ser Ile Leu Gln Glu Glu Leu Thr Thr Tyr Gln Gly Arg 
            900                 905                 910         


Arg 
    


<210> 8762
<211> 274
<212> PRT
<213> Homo sapiens

<400> 8762
Met Gln Asp Glu Lys Leu Arg Asp Glu Thr Glu Gln Pro Val Ser Lys 
1               5                   10                  15      


Val Ile Glu Arg Asn Arg Leu Arg Thr Val Leu Lys Asn Leu Ser Leu 
            20                  25                  30          


Leu Lys Leu Leu Lys Ser Ser Asn Arg Arg Ile Gln Glu Leu His Lys 
        35                  40                  45              


Leu Ala Lys Arg Cys Trp His Ser Leu Leu Ser Val Pro Lys Ile Leu 
    50                  55                  60                  


Arg Ile Ser Ser Gly Glu Asn Ser Ala Cys Asn Lys Thr Lys Gln Asn 
65                  70                  75                  80  


Asn Glu Glu Phe Gln Glu Ile Gly Cys Ser Glu Lys Glu Leu Lys Ser 
                85                  90                  95      


Lys Lys Leu Glu Ser Thr Gly Asp Pro Lys Lys Lys Glu Tyr Lys Glu 
            100                 105                 110         


Trp Lys Ser Gln Val Gln Ser Gly Met Arg Asn Lys Glu Lys Thr Ser 
        115                 120                 125             


Leu Ala Ala Met Pro Arg Lys Glu Lys His Ile Glu Pro Glu Val Pro 
    130                 135                 140                 


Arg Thr Ser Arg Asp Asp Ser Leu Asn Pro Gly Val Gln Gly Arg Gln 
145                 150                 155                 160 


Pro Leu Thr Glu Gly Pro Arg Val Ile Phe Ile Lys Pro Tyr Arg Asn 
                165                 170                 175     


Arg Thr Pro Met Gly His Met Lys Gln Leu Asp Val Ala Asp Gln Trp 
            180                 185                 190         


Ile Trp Phe Glu Gly Leu Pro Thr Arg Ile His Leu Pro Ala Pro Arg 
        195                 200                 205             


Val Met Cys Arg Ser Ser Thr Leu Arg Trp Val Lys Arg Arg Cys Thr 
    210                 215                 220                 


Arg Phe Cys Ser Ala Ser Leu Glu Met Pro Met Trp His Pro Tyr Lys 
225                 230                 235                 240 


Val Asp Val Thr Trp Thr Arg Ala Arg Gly Ala Ser Arg Gly Trp Arg 
                245                 250                 255     


Ser Arg His Gln Leu Lys Gly Arg Asn Gly Trp Arg Asn Ser Arg Val 
            260                 265                 270         


Tyr Lys 
        


<210> 8763
<211> 51
<212> PRT
<213> Homo sapiens

<400> 8763
Met Gln Leu Arg His Ile Gly Asp Asn Ile Asp His Arg Met Val Arg 
1               5                   10                  15      


Glu Asp Leu Gln Gln Asp Gly Arg Asp Ala Leu Asp His Phe Val Phe 
            20                  25                  30          


Phe Phe Phe Arg Arg Val Gln Val Leu Leu His Phe Phe Trp Asn Asn 
        35                  40                  45              


His Leu Leu 
    50      


<210> 8764
<211> 147
<212> PRT
<213> Homo sapiens

<400> 8764
Met Ala Gly Gly Ala Arg Glu Val Leu Thr Leu Gln Leu Gly His Phe 
1               5                   10                  15      


Ala Gly Phe Val Gly Ala His Trp Trp Asn Gln Gln Asp Ala Ala Leu 
            20                  25                  30          


Gly Arg Ala Thr Asp Ser Lys Glu Pro Pro Gly Glu Leu Cys Pro Asp 
        35                  40                  45              


Val Leu Tyr Arg Thr Gly Arg Thr Leu His Gly Gln Glu Thr Tyr Thr 
    50                  55                  60                  


Pro Arg Leu Ile Leu Met Asp Leu Lys Gly Ser Leu Ser Ser Leu Lys 
65                  70                  75                  80  


Glu Glu Gly Gly Leu Tyr Arg Asp Lys Gln Leu Asp Ala Ala Ile Ala 
                85                  90                  95      


Trp Gln Gly Lys Leu Thr Thr His Lys Glu Glu Leu Tyr Pro Lys Asn 
            100                 105                 110         


Pro Tyr Leu Gln Asp Phe Leu Ser Ala Glu Val Arg Ala Ser Val Leu 
        115                 120                 125             


Asn Phe Leu Thr Arg Cys His Asn Leu Arg Val Ser Ile Gly Ala Gly 
    130                 135                 140                 


Ser Ala Glu 
145         


<210> 8765
<211> 558
<212> PRT
<213> Homo sapiens

<400> 8765
Met Ser Val Ser Val His Glu Thr Arg Lys Ser Arg Ser Ser Thr Gly 
1               5                   10                  15      


Ser Met Asn Val Thr Leu Phe His Lys Ala Ser His Pro Asp Cys Val 
            20                  25                  30          


Leu Ala Ala Ser Ser Arg Tyr Phe Glu Ala Met Phe Ser His Gly Leu 
        35                  40                  45              


Arg Glu Ser Arg Asp Asp Thr Val Asn Phe Gln Asp Asn Leu His Pro 
    50                  55                  60                  


Glu Val Leu Glu Leu Leu Leu Asp Phe Ala Tyr Ser Ser Arg Ile Ala 
65                  70                  75                  80  


Ile Asn Glu Glu Asn Ala Glu Ser Leu Leu Glu Ala Gly Asp Met Leu 
                85                  90                  95      


Gln Phe His Asp Val Arg Asp Ala Ala Ala Glu Phe Leu Glu Lys Asn 
            100                 105                 110         


Leu Phe Pro Ser Asn Cys Leu Gly Met Met Leu Leu Ser Asp Ala His 
        115                 120                 125             


Gln Cys Arg Arg Leu Tyr Glu Phe Ser Trp Arg Met Cys Leu Val His 
    130                 135                 140                 


Phe Glu Thr Val Arg Gln Ser Glu Asp Phe Asn Ser Leu Ser Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Asp Leu Ile Ser Ser Asp Glu Leu Glu Thr Glu Asp Glu 
                165                 170                 175     


Arg Val Val Phe Glu Ala Ile Leu Gln Trp Val Lys His Asp Leu Glu 
            180                 185                 190         


Pro Arg Lys Val His Leu Pro Glu Leu Leu Arg Ser Val Arg Leu Ala 
        195                 200                 205             


Leu Leu Pro Ser Asp Cys Leu Gln Glu Ala Val Ser Ser Glu Ala Leu 
    210                 215                 220                 


Leu Met Ala Asp Glu Arg Thr Lys Leu Ile Met Asp Glu Ala Leu Arg 
225                 230                 235                 240 


Cys Lys Thr Arg Ile Leu Gln Asn Asp Gly Val Val Thr Ser Pro Cys 
                245                 250                 255     


Ala Arg Pro Arg Lys Ala Gly His Thr Leu Leu Ile Leu Gly Gly Gln 
            260                 265                 270         


Thr Phe Met Cys Asp Lys Ile Tyr Gln Val Asp His Lys Ala Lys Glu 
        275                 280                 285             


Ile Ile Pro Lys Ala Asp Leu Pro Ser Pro Arg Lys Glu Phe Ser Ala 
    290                 295                 300                 


Ser Ala Ile Gly Cys Lys Val Tyr Val Thr Gly Gly Arg Gly Ser Glu 
305                 310                 315                 320 


Asn Gly Val Ser Lys Asp Val Trp Val Tyr Asp Thr Val His Glu Glu 
                325                 330                 335     


Trp Ser Lys Ala Ala Pro Met Leu Ile Ala Arg Phe Gly His Gly Ser 
            340                 345                 350         


Ala Glu Leu Glu Asn Cys Leu Tyr Val Val Gly Gly His Thr Ser Leu 
        355                 360                 365             


Ala Gly Val Phe Pro Ala Ser Pro Ser Val Ser Leu Lys Gln Val Glu 
    370                 375                 380                 


Lys Tyr Asp Pro Gly Ala Asn Lys Trp Met Met Val Ala Pro Leu Arg 
385                 390                 395                 400 


Asp Gly Val Ser Asn Ala Ala Val Val Ser Ala Lys Leu Lys Leu Phe 
                405                 410                 415     


Val Phe Gly Gly Thr Ser Ile His Arg Asp Met Val Ser Lys Val Gln 
            420                 425                 430         


Cys Tyr Asp Pro Ser Glu Asn Arg Trp Thr Ile Lys Ala Glu Cys Pro 
        435                 440                 445             


Gln Pro Trp Arg Tyr Thr Ala Ala Ala Val Leu Gly Ser Gln Ile Phe 
    450                 455                 460                 


Ile Met Gly Gly Asp Thr Glu Phe Thr Ala Ala Ser Ala Tyr Arg Phe 
465                 470                 475                 480 


Asp Cys Glu Thr Asn Gln Trp Thr Arg Ile Gly Asp Met Thr Ala Lys 
                485                 490                 495     


Arg Met Ser Cys His Ala Leu Ala Ser Gly Asn Lys Leu Tyr Val Val 
            500                 505                 510         


Gly Gly Tyr Phe Gly Thr Gln Arg Cys Lys Thr Leu Asp Cys Tyr Asp 
        515                 520                 525             


Pro Thr Ser Asp Thr Trp Asn Cys Ile Thr Thr Val Pro Tyr Ser Leu 
    530                 535                 540                 


Ile Pro Thr Ala Phe Val Ser Thr Trp Lys His Leu Pro Ala 
545                 550                 555             


<210> 8766
<211> 971
<212> PRT
<213> Homo sapiens

<400> 8766
Met Asn Phe Leu Arg Gly Val Met Gly Gly Gln Ser Ala Gly Pro Gln 
1               5                   10                  15      


His Thr Glu Ala Glu Thr Val Arg Gly Ala Ala Gly Leu Gly Leu Gly 
            20                  25                  30          


Lys Gly Ser Gly Gln Gly Arg Gly Arg Ser Thr Arg Arg Pro Glu Glu 
        35                  40                  45              


Cys Gly Leu Lys Phe Arg His Ser Phe Arg Leu Val Lys His Ile Leu 
    50                  55                  60                  


Tyr His Val Thr Ile Asn Val Ser Asp Ser Glu Ile Ile Gly Tyr Ala 
65                  70                  75                  80  


Leu Asp Thr Leu Tyr Asn Ile Ile Ser Asn Glu Glu Glu Glu Glu Val 
                85                  90                  95      


Gly Gly Ser Gln Glu Glu Asn Ser Thr Arg Gln Ser Glu Asp Leu Gly 
            100                 105                 110         


Ser Gln Phe Thr Glu Ile Phe Ile Lys Gln Gln Glu Asn Val Thr Leu 
        115                 120                 125             


Leu Leu Ser Leu Leu Glu Glu Phe Asp Phe His Val Arg Trp Pro Gly 
    130                 135                 140                 


Val Lys Leu Leu Thr Ser Leu Leu Lys Gln Leu Gly Pro Gln Val Gln 
145                 150                 155                 160 


Gln Ile Ile Leu Val Ser Pro Met Gly Val Ser Arg Leu Met Asp Leu 
                165                 170                 175     


Leu Ala Asp Ser Arg Glu Val Ile Arg Asn Asp Gly Val Leu Leu Leu 
            180                 185                 190         


Gln Ala Leu Thr Arg Ser Asn Gly Ala Ile Gln Lys Ile Val Ala Phe 
        195                 200                 205             


Glu Asn Ala Phe Glu Arg Leu Leu Asp Ile Ile Ser Glu Glu Gly Asn 
    210                 215                 220                 


Ser Asp Gly Gly Ile Val Val Glu Asp Cys Leu Ile Leu Leu Gln Asn 
225                 230                 235                 240 


Leu Leu Lys Asn Asn Asn Ser Asn Gln Asn Phe Phe Lys Glu Gly Ser 
                245                 250                 255     


Tyr Ile Gln Arg Met Lys Pro Trp Phe Glu Val Gly Asp Glu Asn Ser 
            260                 265                 270         


Gly Trp Ser Ala Gln Lys Val Thr Asn Leu His Leu Met Leu Gln Leu 
        275                 280                 285             


Val Arg Val Leu Val Ser Pro Thr Asn Pro Pro Gly Ala Thr Ser Ser 
    290                 295                 300                 


Cys Gln Lys Ala Met Phe Gln Cys Gly Leu Leu Gln Gln Leu Cys Thr 
305                 310                 315                 320 


Ile Leu Met Ala Thr Gly Val Pro Ala Asp Ile Leu Thr Glu Thr Ile 
                325                 330                 335     


Asn Thr Val Ser Glu Val Ile Arg Gly Cys Gln Val Asn Gln Asp Tyr 
            340                 345                 350         


Phe Ala Ser Val Asn Ala Pro Ser Asn Pro Pro Arg Pro Ala Ile Val 
        355                 360                 365             


Val Leu Leu Met Ser Met Val Asn Glu Arg Gln Pro Phe Val Leu Arg 
    370                 375                 380                 


Cys Ala Val Leu Tyr Cys Phe Gln Cys Phe Leu Tyr Lys Asn Gln Lys 
385                 390                 395                 400 


Gly Gln Gly Glu Ile Val Ser Thr Leu Leu Pro Ser Thr Ile Asp Ala 
                405                 410                 415     


Thr Gly Asn Ser Val Ser Ala Gly Gln Leu Leu Cys Gly Gly Leu Phe 
            420                 425                 430         


Ser Thr Asp Ser Leu Ser Asn Trp Cys Ala Ala Val Ala Leu Ala His 
        435                 440                 445             


Ala Leu Gln Glu Asn Ala Thr Gln Lys Glu Gln Leu Leu Arg Val Gln 
    450                 455                 460                 


Leu Ala Thr Ser Ile Gly Asn Pro Pro Val Ser Leu Leu Gln Gln Cys 
465                 470                 475                 480 


Thr Asn Ile Leu Ser Gln Gly Asp Lys Ile Asp Arg Arg Gly Ser Lys 
                485                 490                 495     


Ile Gln Thr Arg Val Gly Leu Leu Met Leu Leu Cys Thr Trp Leu Ser 
            500                 505                 510         


Asn Cys Pro Ile Ala Val Thr His Phe Leu His Asn Ser Ala Asn Val 
        515                 520                 525             


Pro Phe Leu Thr Gly Gln Ile Ala Glu Asn Leu Gly Glu Glu Glu Gln 
    530                 535                 540                 


Leu Val Gln Gly Leu Cys Ala Leu Leu Leu Gly Ile Ser Ile Tyr Phe 
545                 550                 555                 560 


Asn Asp Asn Ser Leu Glu Ser Tyr Met Lys Glu Lys Leu Lys Gln Leu 
                565                 570                 575     


Ile Glu Lys Arg Ile Gly Lys Glu Asn Phe Ile Glu Lys Leu Gly Phe 
            580                 585                 590         


Ile Ser Lys His Glu Leu Tyr Ser Arg Ala Ser Gln Lys Pro Gln Pro 
        595                 600                 605             


Asn Phe Pro Ser Pro Glu Tyr Met Ile Phe Asp His Glu Phe Thr Lys 
    610                 615                 620                 


Leu Val Lys Glu Leu Glu Gly Val Ile Thr Lys Ala Ile Tyr Lys Ser 
625                 630                 635                 640 


Ser Glu Glu Asp Lys Lys Glu Glu Glu Val Lys Lys Thr Leu Glu Gln 
                645                 650                 655     


His Asp Asn Ile Val Thr His Tyr Lys Asn Met Ile Arg Glu Gln Asp 
            660                 665                 670         


Leu Gln Leu Glu Glu Leu Arg Gln Gln Val Ser Thr Leu Lys Cys Gln 
        675                 680                 685             


Asn Glu Gln Leu Gln Thr Ala Val Thr Gln Gln Val Ser Gln Ile Gln 
    690                 695                 700                 


Gln His Lys Asp Gln Tyr Asn Leu Leu Lys Ile Gln Leu Gly Lys Asp 
705                 710                 715                 720 


Asn Gln His Gln Gly Ser Tyr Ser Glu Gly Ala Gln Met Asn Gly Ile 
                725                 730                 735     


Gln Pro Glu Glu Ile Gly Arg Leu Arg Glu Glu Ile Glu Glu Leu Lys 
            740                 745                 750         


Arg Asn Gln Glu Leu Leu Gln Ser Gln Leu Thr Glu Lys Asp Ser Met 
        755                 760                 765             


Ile Glu Asn Met Lys Ser Ser Gln Thr Ser Gly Thr Asn Glu Gln Ser 
    770                 775                 780                 


Ser Ala Ile Val Ser Ala Arg Asp Ser Glu Gln Val Ala Glu Leu Lys 
785                 790                 795                 800 


Gln Glu Leu Ala Thr Leu Lys Ser Gln Leu Asn Ser Gln Ser Val Glu 
                805                 810                 815     


Ile Thr Lys Leu Gln Thr Glu Lys Gln Glu Leu Leu Gln Lys Thr Glu 
            820                 825                 830         


Ala Phe Ala Lys Ser Val Glu Val Gln Gly Glu Thr Glu Thr Ile Ile 
        835                 840                 845             


Ala Thr Lys Thr Thr Asp Val Glu Gly Arg Leu Ser Ala Leu Leu Gln 
    850                 855                 860                 


Glu Thr Lys Glu Leu Lys Asn Glu Ile Lys Ala Leu Ser Glu Glu Arg 
865                 870                 875                 880 


Thr Ala Ile Lys Glu Gln Leu Asp Ser Ser Asn Ser Thr Ile Ala Ile 
                885                 890                 895     


Leu Gln Thr Glu Lys Asp Lys Leu Glu Leu Glu Ile Thr Asp Ser Lys 
            900                 905                 910         


Lys Glu Gln Asp Asp Leu Leu Val Leu Leu Ala Asp Gln Asp Gln Lys 
        915                 920                 925             


Ile Leu Ser Leu Lys Asn Lys Leu Lys Asp Leu Gly His Pro Val Glu 
    930                 935                 940                 


Glu Glu Asp Glu Leu Glu Ser Gly Asp Gln Glu Asp Glu Asp Asp Glu 
945                 950                 955                 960 


Ser Glu Asp Pro Gly Lys Asp Leu Asp His Ile 
                965                 970     


<210> 8767
<211> 85
<212> PRT
<213> Homo sapiens

<400> 8767
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys 
    50                  55                  60                  


Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Pro Thr Cys Lys Val 
                85  


<210> 8768
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8768
Xaa Gly Arg Ala Pro Gly Pro Ala Ile Gly Gly Arg Arg Ala Gly Asp 
1               5                   10                  15      


Ser Cys Pro Gly Trp Arg Arg Arg Ser Arg Ser Arg Gly Arg Gly Gln 
            20                  25                  30          


Arg Leu Ser His Gly Pro Arg Arg Arg Pro Gln Leu Leu Thr Glu Thr 
        35                  40                  45              


Arg Arg Pro Val Leu Val Gln Trp Leu 
    50                  55          


<210> 8769
<211> 311
<212> PRT
<213> Homo sapiens

<400> 8769
Met Val Ser Leu Arg Val Asn Pro Leu Ser Leu Val Glu Ile Ile Leu 
1               5                   10                  15      


His Val Val Arg Gln Met Thr Asp Pro Asn Val Ala Leu Thr Phe Leu 
            20                  25                  30          


Glu Lys Thr Arg Glu Lys Val Lys Ser Ser Asp Glu Ala Val Ile Leu 
        35                  40                  45              


Cys Lys Thr Ala Ile Gly Ala Leu Lys Leu Asn Ile Gly Asp Leu Gln 
    50                  55                  60                  


Val Thr Lys Glu Thr Ile Glu Asp Val Glu Glu Met Leu Asn Asn Leu 
65                  70                  75                  80  


Pro Gly Val Thr Ser Val His Ser Arg Phe Tyr Asp Leu Ser Ser Lys 
                85                  90                  95      


Tyr Tyr Gln Thr Ile Gly Asn His Ala Ser Tyr Tyr Lys Asp Ala Leu 
            100                 105                 110         


Arg Phe Leu Gly Cys Val Asp Ile Lys Asp Leu Pro Val Ser Glu Gln 
        115                 120                 125             


Gln Glu Arg Ala Phe Thr Leu Gly Leu Ala Gly Leu Leu Gly Glu Gly 
    130                 135                 140                 


Val Phe Asn Phe Gly Glu Leu Leu Met His Pro Val Leu Glu Ser Leu 
145                 150                 155                 160 


Arg Asn Thr Asp Arg Gln Trp Leu Ile Asp Thr Leu Tyr Ala Phe Asn 
                165                 170                 175     


Ser Gly Asn Val Glu Arg Phe Gln Thr Leu Lys Thr Ala Trp Gly Gln 
            180                 185                 190         


Gln Pro Asp Leu Ala Ala Asn Glu Ala Gln Leu Leu Arg Lys Ile Gln 
        195                 200                 205             


Leu Leu Cys Leu Met Glu Met Thr Phe Thr Arg Pro Ala Asn His Arg 
    210                 215                 220                 


Gln Leu Thr Phe Glu Glu Ile Ala Lys Ser Ala Lys Ile Thr Val Asn 
225                 230                 235                 240 


Glu Val Glu Leu Leu Val Met Lys Ala Leu Ser Val Gly Leu Val Lys 
                245                 250                 255     


Gly Ser Ile Asp Glu Val Asp Lys Arg Val His Met Thr Trp Val Gln 
            260                 265                 270         


Pro Arg Val Leu Asp Leu Gln Gln Ile Lys Gly Met Lys Asp Arg Leu 
        275                 280                 285             


Glu Phe Trp Cys Thr Asp Val Lys Ser Met Glu Met Leu Val Glu His 
    290                 295                 300                 


Gln Ala His Asp Ile Leu Thr 
305                 310     


<210> 8770
<211> 386
<212> PRT
<213> Homo sapiens

<400> 8770
Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys Ser Val Met Asn 
1               5                   10                  15      


Thr Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys Ser Asn Phe Glu 
            20                  25                  30          


Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu Leu Asn Ser Ser 
        35                  40                  45              


Asn Ile Ala Glu His Pro Gly Phe Met Lys Thr Gly Glu Cys Leu Arg 
    50                  55                  60                  


Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe Ala Met Ser Lys 
65                  70                  75                  80  


His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu Gln Glu Asn Asp 
                85                  90                  95      


Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Thr Asp Pro Gly Lys Lys 
            100                 105                 110         


Phe Ser Gly Arg Pro Met Cys Thr Leu Leu Thr Asn Lys Arg Tyr Glu 
        115                 120                 125             


Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile Gly Arg Pro Leu 
    130                 135                 140                 


Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val Tyr His Ala Asn 
145                 150                 155                 160 


Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile Ala Ala Asn Lys 
                165                 170                 175     


Gly Thr Ser Glu Gln Glu Thr Lys Gly Leu Pro Ser Lys Lys Gly Ile 
            180                 185                 190         


Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys Ile Val Leu Ala 
        195                 200                 205             


Ser Gln Ser Ile Gln Asn Thr Val Tyr Asn Asp Gly Gln Ser Ser Ala 
    210                 215                 220                 


Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys Leu Arg Asn Ala 
225                 230                 235                 240 


Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys Gln Glu Asn Gly 
                245                 250                 255     


Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Thr Glu Ser Ser Glu Ser 
            260                 265                 270         


Ser Glu Thr Cys Ser Ser Lys Ser His Asp Gly Asp Lys Phe Ile Pro 
        275                 280                 285             


Ala Pro Pro Ser Ser Pro Leu Arg Lys Gln Glu Leu Glu Asn Leu Lys 
    290                 295                 300                 


Cys Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu Ala Leu Gly Asp 
305                 310                 315                 320 


Asn Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu Gln Gln Pro Lys 
                325                 330                 335     


Leu Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr Ala Ala Glu Ala 
            340                 345                 350         


Leu Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Thr His Leu Asn Pro 
        355                 360                 365             


Glu Asn Val Thr Asp Val Ser Leu Gly Ile Ser Ser Asn Glu Gln Asp 
    370                 375                 380                 


Gln Gly 
385     


<210> 8771
<211> 531
<212> PRT
<213> Homo sapiens

<400> 8771
Met Leu Gln Glu Leu Asn Phe Gly Ala Tyr Leu Gly Leu Pro Ala Phe 
1               5                   10                  15      


Leu Leu Pro Leu Asn Gln Glu Asp Asn Thr Asn Leu Ala Arg Val Leu 
            20                  25                  30          


Thr Asn His Ile His Thr Gly His His Ser Ser Met Phe Trp Met Arg 
        35                  40                  45              


Val Pro Leu Val Ala Pro Glu Asp Leu Arg Asp Asp Ile Ile Glu Asn 
    50                  55                  60                  


Ala Pro Thr Thr His Thr Glu Glu Tyr Ser Gly Glu Glu Lys Thr Trp 
65                  70                  75                  80  


Met Trp Trp His Asn Phe Arg Thr Leu Cys Asp Tyr Ser Lys Arg Ile 
                85                  90                  95      


Ala Val Ala Leu Glu Ile Gly Ala Asp Leu Pro Ser Asn His Val Ile 
            100                 105                 110         


Asp Arg Trp Leu Gly Glu Pro Ile Lys Ala Ala Ile Leu Pro Thr Ser 
        115                 120                 125             


Ile Phe Leu Thr Asn Lys Lys Gly Phe Pro Val Leu Ser Lys Met His 
    130                 135                 140                 


Gln Arg Leu Ile Phe Arg Leu Leu Lys Leu Glu Val Gln Phe Ile Ile 
145                 150                 155                 160 


Thr Gly Thr Asn His His Ser Glu Lys Glu Phe Cys Ser Tyr Leu Gln 
                165                 170                 175     


Tyr Leu Glu Tyr Leu Ser Gln Asn Arg Pro Pro Pro Asn Ala Tyr Glu 
            180                 185                 190         


Leu Phe Ala Lys Gly Tyr Glu Asp Tyr Leu Gln Ser Pro Leu Gln Pro 
        195                 200                 205             


Leu Met Asp Asn Leu Glu Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp 
    210                 215                 220                 


Pro Ile Lys Tyr Ser Gln Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu 
225                 230                 235                 240 


Asp Arg Val Pro Glu Glu Glu Lys Asp Thr Asn Val Gln Val Leu Met 
                245                 250                 255     


Val Leu Gly Ala Gly Arg Gly Pro Leu Val Asn Ala Ser Leu Arg Ala 
            260                 265                 270         


Ala Lys Gln Ala Asp Arg Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn 
        275                 280                 285             


Pro Asn Ala Val Val Thr Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly 
    290                 295                 300                 


Ser Gln Val Thr Val Val Ser Ser Asp Met Arg Glu Trp Val Ala Pro 
305                 310                 315                 320 


Glu Lys Ala Asp Ile Ile Val Ser Glu Leu Leu Gly Ser Phe Ala Asp 
                325                 330                 335     


Asn Glu Leu Ser Pro Glu Cys Leu Asp Gly Ala Gln His Phe Leu Lys 
            340                 345                 350         


Asp Asp Gly Val Ser Ile Pro Gly Glu Tyr Thr Ser Phe Leu Ala Pro 
        355                 360                 365             


Ile Ser Ser Ser Lys Leu Tyr Asn Glu Val Arg Ala Cys Arg Glu Lys 
    370                 375                 380                 


Asp Arg Asp Pro Glu Ala Gln Phe Glu Met Pro Tyr Val Val Arg Leu 
385                 390                 395                 400 


His Asn Phe His Gln Leu Ser Ala Pro Gln Pro Cys Phe Thr Phe Ser 
                405                 410                 415     


His Pro Asn Arg Asp Pro Met Ile Asp Asn Asn Arg Tyr Cys Thr Leu 
            420                 425                 430         


Glu Phe Pro Val Glu Val Asn Thr Val Leu His Gly Phe Ala Gly Tyr 
        435                 440                 445             


Phe Glu Thr Val Leu Tyr Gln Asp Ile Thr Leu Ser Ile Arg Pro Glu 
    450                 455                 460                 


Thr His Ser Pro Gly Met Phe Ser Trp Phe Pro Ile Leu Phe Pro Ile 
465                 470                 475                 480 


Lys Gln Pro Ile Thr Val Arg Glu Gly Gln Thr Ile Cys Val Arg Phe 
                485                 490                 495     


Trp Arg Cys Ser Asn Ser Lys Lys Val Trp Tyr Glu Trp Ala Val Thr 
            500                 505                 510         


Ala Pro Val Cys Ser Ala Ile His Asn Pro Thr Gly Arg Ser Tyr Thr 
        515                 520                 525             


Ile Gly Leu 
    530     


<210> 8772
<211> 262
<212> PRT
<213> Homo sapiens

<400> 8772
Met Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly 
            20                  25                  30          


Gln Cys Pro Trp Arg Gly Ala Gly Ser Phe Leu Asp Pro Glu Ile Lys 
        35                  40                  45              


Ala Phe Leu Glu Glu Asn Thr Glu Val Thr Ser Ser Gly Ser Leu Thr 
    50                  55                  60                  


Pro Glu Ile Gln Leu Arg Leu Leu Thr Pro Arg Cys Lys Phe Trp Trp 
65                  70                  75                  80  


Glu Arg Ala Asp Leu Trp Pro His Ser Asp Pro Tyr Trp Ala Ile Tyr 
                85                  90                  95      


Trp Pro Gly Gly Gln Ala Leu Ser Arg Tyr Leu Leu Asp Asn Pro Asp 
            100                 105                 110         


Val Val Arg Gly Lys Ser Val Leu Asp Leu Gly Ser Gly Cys Gly Ala 
        115                 120                 125             


Thr Ala Ile Ala Ala Lys Met Ser Gly Ala Ser Arg Ile Leu Ala Asn 
    130                 135                 140                 


Asp Ile Asp Pro Ile Ala Gly Met Ala Ile Thr Leu Asn Cys Glu Leu 
145                 150                 155                 160 


Asn Arg Leu Asn Pro Phe Pro Ile Leu Ile Gln Asn Ile Leu Asn Leu 
                165                 170                 175     


Glu Gln Asp Lys Trp Asp Leu Val Val Leu Gly Asp Met Phe Tyr Asp 
            180                 185                 190         


Glu Asp Leu Ala Asp Ser Leu His Gln Trp Leu Lys Lys Cys Phe Trp 
        195                 200                 205             


Thr Tyr Arg Thr Arg Val Leu Ile Gly Asp Pro Gly Arg Pro Gln Phe 
    210                 215                 220                 


Ser Gly His Ser Ile Gln His His Leu His Lys Val Val Glu Tyr Ser 
225                 230                 235                 240 


Leu Leu Glu Ser Thr Arg Gln Glu Asn Ser Gly Leu Thr Thr Ser Thr 
                245                 250                 255     


Val Trp Gly Phe Gln Pro 
            260         


<210> 8773
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8773
Met Ala Ala Pro Ser Pro Ser Gly Thr Pro Val Ser Ser Met Gln Gly 
1               5                   10                  15      


Lys Arg Lys Ala Leu Lys Leu Asn Phe Ala Asn Pro Pro Phe Lys Ser 
            20                  25                  30          


Thr Ala Arg Phe Thr Leu Asn Pro Asn Pro Thr Gly Val Gln Asn Pro 
        35                  40                  45              


His Ile Glu Arg Leu Arg Thr His Ser Ile Glu Ser Ser Gly Lys Leu 
    50                  55                  60                  


Lys Ile Ser Pro Glu Gln His Trp Asp Phe Thr Ala Glu Asp Leu Lys 
65                  70                  75                  80  


Asp Leu Gly Glu Ile Gly Arg Gly Ala Tyr Gly Ser Val Asn Lys Met 
                85                  90                  95      


Val His Lys Pro Ser Gly Gln Ile Met Ala Val Lys Arg Ile Arg Ser 
            100                 105                 110         


Thr Val Asp Glu Lys Glu Gln Lys Gln Leu Leu Met Asp Leu Asp Val 
        115                 120                 125             


Val Met Arg Ser Ser Asp Cys Pro Tyr Ile Val Gln Phe Tyr Gly Ala 
    130                 135                 140                 


Leu Phe Arg Glu Gly Asp Cys Trp Ile Cys Met Glu Leu Met Ser Thr 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Tyr Lys Tyr Val Tyr Ser Val Leu Asp Asp Val 
                165                 170                 175     


Ile Pro Glu Glu Ile Leu Gly Lys Ile Thr Leu Ala Thr Val Lys Ala 
            180                 185                 190         


Leu Asn His Leu Lys Glu Asn Leu Lys Ile Ile His Arg Asp Ile Lys 
        195                 200                 205             


Pro Ser Asn Ile Leu Leu Asp Arg Ser Gly Asn Ile Lys Leu Cys Asp 
    210                 215                 220                 


Phe Gly Ile Ser Gly Gln Leu Val Asp Ser Ile Ala Lys Thr Arg Asp 
225                 230                 235                 240 


Ala Gly Cys Arg Pro Tyr Met Ala Pro Glu Arg Ile Asp Pro Ser Ala 
                245                 250                 255     


Ser Arg Gln Gly Tyr Asp Val Arg Ser Asp Val Trp Ser Leu Gly Ile 
            260                 265                 270         


Thr Leu Tyr Glu Leu Ala Thr Gly Arg Phe Pro Tyr Pro Lys Trp Asn 
        275                 280                 285             


Ser Val Phe Asp Gln Leu Thr Gln Val Val Lys Gly Asp Pro Pro Gln 
    290                 295                 300                 


Leu Ser Asn Ser Glu Glu Arg Glu Phe Ser Pro Ser Phe Ile Asn Phe 
305                 310                 315                 320 


Val Asn Leu Cys Leu Thr Lys Asp Glu Ser Lys Arg Pro Lys Tyr Lys 
                325                 330                 335     


Glu Leu Leu Lys His Pro Phe Ile Leu Met Tyr Glu Glu Arg Ala Val 
            340                 345                 350         


Glu Val Ala Cys Tyr Val Cys Lys Ile Leu Asp Gln Met Pro Ala Thr 
        355                 360                 365             


Pro Ser Ser Pro Met Tyr Val Asp 
    370                 375     


<210> 8774
<211> 344
<212> PRT
<213> Homo sapiens

<400> 8774
Met Ala Gly Ser Gly Cys Ala Trp Gly Ala Glu Pro Pro Arg Phe Leu 
1               5                   10                  15      


Glu Ala Phe Gly Arg Leu Trp Gln Val Gln Ser Arg Leu Gly Ser Gly 
            20                  25                  30          


Ser Ser Ala Ser Val Tyr Arg Val Arg Cys Cys Gly Asn Pro Gly Ser 
        35                  40                  45              


Pro Pro Gly Ala Leu Lys Gln Phe Leu Pro Pro Gly Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ser Ala Ala Glu Tyr Gly Phe Arg Lys Glu Arg Ala Ala Leu 
65                  70                  75                  80  


Glu Gln Leu Gln Gly His Arg Asn Ile Val Thr Leu Tyr Gly Val Phe 
                85                  90                  95      


Thr Ile His Phe Ser Pro Asn Val Pro Ser Arg Cys Leu Leu Leu Glu 
            100                 105                 110         


Leu Leu Asp Val Ser Val Ser Glu Leu Leu Leu Tyr Ser Ser His Gln 
        115                 120                 125             


Gly Cys Ser Met Trp Met Ile Gln His Cys Ala Arg Asp Val Leu Glu 
    130                 135                 140                 


Ala Leu Ala Phe Leu His His Glu Gly Tyr Val His Ala Asp Leu Lys 
145                 150                 155                 160 


Pro Arg Asn Ile Leu Trp Ser Ala Glu Asn Glu Cys Phe Lys Leu Ile 
                165                 170                 175     


Asp Phe Gly Leu Ser Phe Lys Glu Gly Asn Gln Asp Val Lys Tyr Ile 
            180                 185                 190         


Gln Thr Asp Gly Tyr Arg Ala Pro Glu Ala Glu Leu Gln Asn Cys Leu 
        195                 200                 205             


Ala Gln Ala Gly Leu Gln Ser Asp Thr Glu Cys Thr Ser Ala Val Asp 
    210                 215                 220                 


Leu Trp Ser Leu Gly Ile Ile Leu Leu Glu Met Phe Ser Gly Met Lys 
225                 230                 235                 240 


Leu Lys His Thr Val Arg Ser Gln Glu Trp Lys Ala Asn Ser Ser Ala 
                245                 250                 255     


Ile Ile Asp His Ile Phe Ala Ser Lys Ala Val Val Asn Ala Ala Ile 
            260                 265                 270         


Pro Ala Tyr His Leu Arg Asp Leu Ile Lys Ser Met Leu His Asp Asp 
        275                 280                 285             


Pro Ser Arg Arg Ile Pro Ala Glu Met Ala Leu Cys Ser Pro Phe Phe 
    290                 295                 300                 


Ser Ile Pro Phe Ala Pro His Ile Glu Asp Leu Val Met Leu Pro Thr 
305                 310                 315                 320 


Pro Val Leu Arg Leu Leu Asn Val Leu Asp Asp Asp Tyr Leu Glu Asn 
                325                 330                 335     


Glu Glu Glu Tyr Glu Gly Leu Cys 
            340                 


<210> 8775
<211> 488
<212> PRT
<213> Homo sapiens

<400> 8775
Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala Asn Met Leu 
1               5                   10                  15      


Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn Ile Leu Arg 
            20                  25                  30          


Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala Leu Thr Glu 
        35                  40                  45              


Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser Asn Leu His 
    50                  55                  60                  


Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile Ala Val Gly 
65                  70                  75                  80  


Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp Leu Thr Ser 
                85                  90                  95      


Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser Ala Val Val 
            100                 105                 110         


Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser Met Gly Ser 
        115                 120                 125             


Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala Pro Glu Val 
    130                 135                 140                 


Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe Ser Tyr Gly 
145                 150                 155                 160 


Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp Pro Asp Tyr 
                165                 170                 175     


Leu Pro Arg Thr Glu Asn Phe Gly Leu Asp Tyr Asp Ala Phe Gln His 
            180                 185                 190         


Met Val Gly Asp Cys Pro Pro Asp Phe Leu Gln Leu Thr Phe Asn Cys 
        195                 200                 205             


Cys Asn Met Asp Pro Lys Leu Arg Pro Ser Phe Val Glu Ile Gly Lys 
    210                 215                 220                 


Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln Glu Glu Glu Gln Glu Arg 
225                 230                 235                 240 


Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly Leu Leu Glu Lys Ala Pro 
                245                 250                 255     


Gly Val Lys Arg Leu Ser Ser Leu Asp Asp Lys Ile Pro His Lys Ser 
            260                 265                 270         


Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser Arg Ser Gln Ser Asp Ile 
        275                 280                 285             


Phe Ser Arg Lys Pro Pro Arg Thr Val Ser Val Leu Asp Pro Tyr Tyr 
    290                 295                 300                 


Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro Lys Val Asn Pro Phe Ser 
305                 310                 315                 320 


Ala Arg Gln Asp Leu Met Gly Gly Lys Ile Lys Phe Phe Asp Leu Pro 
                325                 330                 335     


Ser Lys Ser Val Ile Ser Leu Val Phe Asp Leu Asp Ala Pro Gly Pro 
            340                 345                 350         


Gly Thr Met Pro Leu Ala Asp Trp Gln Glu Pro Leu Ala Pro Pro Ile 
        355                 360                 365             


Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro Glu Phe Leu His Gln Glu 
    370                 375                 380                 


Ala Cys Pro Phe Val Gly Arg Glu Glu Ser Leu Ser Asp Gly Pro Pro 
385                 390                 395                 400 


Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val Lys Glu Ile Pro Pro Phe 
                405                 410                 415     


Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala His Glu Ala Met Asp Cys 
            420                 425                 430         


Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly Ser Arg Pro Gln Gly Thr 
        435                 440                 445             


Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu Met Glu Val Glu Glu Arg 
    450                 455                 460                 


Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser Thr Ser Gly Ile Gly Leu 
465                 470                 475                 480 


Gln Thr Gln Gly Lys Gln Asp Gly 
                485             


<210> 8776
<211> 485
<212> PRT
<213> Homo sapiens

<400> 8776
Met Thr Leu Trp Ile Leu Pro Lys Phe Lys Ala Val Asp Phe Ser Pro 
1               5                   10                  15      


Ser Leu Ala Ala Tyr Thr His Thr Trp Leu Leu Pro Arg Phe Leu Glu 
            20                  25                  30          


Ile Leu Ile Gln Cys Gly His Cys Lys Arg Leu Ala Pro Glu Tyr Glu 
        35                  40                  45              


Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu Ala Lys Val Asp 
    50                  55                  60                  


Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly Val Ser Gly Tyr 
65                  70                  75                  80  


Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala Gly Ala Tyr Asp 
                85                  90                  95      


Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu Lys Lys Gln Ala 
            100                 105                 110         


Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu Phe Lys Lys Phe 
        115                 120                 125             


Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe Asp Asp Ser Phe 
    130                 135                 140                 


Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser Asn Leu Arg Asp 
145                 150                 155                 160 


Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu Val Asn Glu Tyr 
                165                 170                 175     


Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro Ser His Leu Thr 
            180                 185                 190         


Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu Gln Lys Met Thr 
        195                 200                 205             


Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile Phe Gly Ile Cys 
    210                 215                 220                 


Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln Gly Lys Asp Leu 
225                 230                 235                 240 


Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn Ala Lys Gly Ser 
                245                 250                 255     


Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys Lys Phe Leu Asp 
            260                 265                 270         


Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg Lys Thr Phe Ser 
        275                 280                 285             


His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala Gly Glu Ile Pro 
    290                 295                 300                 


Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe Val Met Gln Glu 
305                 310                 315                 320 


Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe Leu Gln Asp Tyr 
                325                 330                 335     


Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu Pro Ile Pro Glu 
            340                 345                 350         


Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu Asn Phe Asp Glu 
        355                 360                 365             


Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu Phe Tyr Ala Pro 
    370                 375                 380                 


Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr Lys Glu Leu Gly 
385                 390                 395                 400 


Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala Lys Met Asp Ala 
                405                 410                 415     


Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg Gly Phe Pro Thr 
            420                 425                 430         


Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro Lys Lys Tyr Glu 
        435                 440                 445             


Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu Gln Arg Glu Ala 
    450                 455                 460                 


Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys Lys Lys Lys Lys 
465                 470                 475                 480 


Ala Gln Glu Asp Leu 
                485 


<210> 8777
<211> 294
<212> PRT
<213> Homo sapiens

<400> 8777
Met Ser Ala Gln His Phe Val Ser Thr Glu Gln Val Glu Leu Pro Gly 
1               5                   10                  15      


Pro Gly Gln Trp Val Val Ala Glu Cys Pro Ala Arg Val Asp Phe Ser 
            20                  25                  30          


Gly Gly Trp Ser Asp Thr Pro Pro Leu Ala Tyr Glu Leu Gly Gly Ala 
        35                  40                  45              


Val Leu Gly Leu Ala Val Arg Val Asp Gly Arg Arg Pro Ile Gly Ala 
    50                  55                  60                  


Arg Ala Arg Arg Ile Pro Glu Pro Glu Leu Trp Leu Ala Val Gly Pro 
65                  70                  75                  80  


Arg Gln Asp Glu Met Thr Val Lys Ile Val Cys Arg Cys Leu Ala Asp 
                85                  90                  95      


Leu Arg Asp Tyr Cys Gln Pro His Ala Pro Gly Ala Leu Leu Lys Ala 
            100                 105                 110         


Ala Phe Ile Cys Ala Gly Ile Val His Val His Ser Glu Leu Gln Leu 
        115                 120                 125             


Ser Glu Gln Leu Leu Arg Thr Phe Gly Gly Gly Phe Glu Leu His Thr 
    130                 135                 140                 


Trp Ser Glu Leu Pro His Gly Ser Gly Leu Gly Thr Ser Ser Ile Leu 
145                 150                 155                 160 


Ala Gly Thr Ala Leu Ala Ala Leu Gln Arg Ala Ala Gly Arg Val Val 
                165                 170                 175     


Gly Thr Glu Ala Leu Ile His Ala Val Leu His Leu Glu Gln Val Leu 
            180                 185                 190         


Thr Thr Gly Gly Gly Trp Gln Asp Gln Val Gly Gly Leu Met Pro Gly 
        195                 200                 205             


Ile Lys Val Gly Arg Ser Arg Ala Gln Leu Pro Leu Lys Val Glu Val 
    210                 215                 220                 


Glu Glu Val Thr Val Pro Glu Gly Phe Val Gln Lys Leu Asn Asp His 
225                 230                 235                 240 


Leu Leu Leu Val Tyr Thr Gly Lys Thr Arg Leu Ala Arg Asn Leu Leu 
                245                 250                 255     


Gln Asp Val Leu Arg Ser Trp Tyr Ala Arg Leu Pro Ala Val Val Gln 
            260                 265                 270         


Asn Ala His Ser Leu Val Arg Gln Thr Glu Glu Cys Ala Glu Gly Phe 
        275                 280                 285             


Arg Gln Gly Ser His Ile 
    290                 


<210> 8778
<211> 314
<212> PRT
<213> Homo sapiens

<400> 8778
Val Gly Arg Met Glu Gly Cys Ser Ser Pro Ile Val Val Lys Phe Ala 
1               5                   10                  15      


Asp Thr Gln Lys Asp Lys Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala 
            20                  25                  30          


Gln Gln Met Gln Gln Leu Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly 
        35                  40                  45              


Leu Gly Gly Leu Thr Pro Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr 
    50                  55                  60                  


Ser Ser Ser Asn Leu Gly Ala Phe Ser Gly Ile Gln Gln Met Ala Gly 
65                  70                  75                  80  


Met Asn Ala Leu Gln Leu Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Gln Thr Ser Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser 
            100                 105                 110         


Thr Thr Ser Ser Ala Leu Gly Ala Leu Thr Ser Pro Val Ala Ala Ser 
        115                 120                 125             


Thr Pro Asn Ser Thr Ala Gly Ala Ala Met Asn Ser Leu Thr Ser Leu 
    130                 135                 140                 


Gly Thr Leu Gln Gly Leu Ala Gly Ala Thr Val Gly Leu Asn Asn Ile 
145                 150                 155                 160 


Asn Ala Leu Ala Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr 
                165                 170                 175     


Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala 
            180                 185                 190         


Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr 
        195                 200                 205             


Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu 
    210                 215                 220                 


Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe 
225                 230                 235                 240 


Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile 
                245                 250                 255     


Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe 
            260                 265                 270         


Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln 
        275                 280                 285             


Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu 
    290                 295                 300                 


Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
305                 310                 


<210> 8779
<211> 360
<212> PRT
<213> Homo sapiens

<400> 8779
Ser Met Glu Lys Thr Tyr Thr Ser Thr Ser Asn Asn Ser Ile Ser Gly 
1               5                   10                  15      


Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg Phe Thr Asn Ala Asn 
            20                  25                  30          


Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly Lys Asp Val Ser Glu 
        35                  40                  45              


Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser Ser Ala His Ser Ser 
    50                  55                  60                  


Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg Asn Pro Gly Thr Thr 
65                  70                  75                  80  


Val Ser Ala Ala Ser Pro Phe Pro Gln Ala Gly Tyr Lys Arg Ala Gln 
                85                  90                  95      


Thr Ser Gly Ile Glu Glu Glu Thr Val Lys Glu Lys Lys Arg Lys Gly 
            100                 105                 110         


Asn Lys Gln Ser Lys His Gly Pro Gly Arg Pro Lys Gly Asn Lys Asn 
        115                 120                 125             


Gln Glu Asn Val Ser His Leu Ser Val Ser Ser Ala Ser Pro Thr Ser 
    130                 135                 140                 


Ser Val Ala Ser Ala Ala Gly Ser Ile Thr Ser Ser Ser Leu Gln Lys 
145                 150                 155                 160 


Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu Gln Ser Leu Ser Val Gly 
                165                 170                 175     


Ser Ser Pro Val Gly Ser Glu Ile Ser Met Gln Tyr Arg His Asp Gly 
            180                 185                 190         


Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu Leu Asn Ala Ile His Asn 
        195                 200                 205             


Asp Arg Gly Asp Ser Ser Thr Leu Thr Lys Gln Glu Leu Lys Phe Ile 
    210                 215                 220                 


Gly Ile Tyr Asn Ser Asn Asp Val Ala Val Ser Phe Pro Asn Val Val 
225                 230                 235                 240 


Ser Gly Ser Gly Ser Ser Thr Pro Val Ser Ser Ser His Leu Pro Gln 
                245                 250                 255     


Gln Ser Ser Gly His Leu Gln Gln Val Gly Ala Leu Ser Pro Ser Ala 
            260                 265                 270         


Val Ser Ser Ala Ala Pro Ala Val Ala Thr Thr Gln Ala Asn Thr Leu 
        275                 280                 285             


Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser His Met Tyr Gly Asn Arg 
    290                 295                 300                 


Ser Asn Ser Ser Met Ala Ala Leu Ile Ala Gln Ser Glu Asn Asn Gln 
305                 310                 315                 320 


Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg Asn Leu Val Gly Arg Gly 
                325                 330                 335     


Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg Ser Pro Val Ser Ser Leu 
            340                 345                 350         


Gln Ile Arg Tyr Asp Gln Pro Gly 
        355                 360 


<210> 8780
<211> 307
<212> PRT
<213> Homo sapiens

<400> 8780
Met Gln Ser Leu Thr Leu Asp Leu Leu Gly Pro Ser Glu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Asn Met Gly Asn Thr Ser Phe Asn Glu Val Met Glu Ala Gln 
            20                  25                  30          


Leu Pro Ser His Gly Gly Pro Lys Pro Ser Ala Glu Ser Asp Met Gly 
        35                  40                  45              


Thr Arg Arg Asp Tyr Ile Met Ala Lys Tyr Val Glu His Arg Phe Ala 
    50                  55                  60                  


Arg Arg Cys Thr Pro Glu Pro Gln Arg Leu Trp Thr Ala Ile Cys Asn 
65                  70                  75                  80  


Arg Asp Leu Leu Ser Val Leu Glu Ala Phe Ala Asn Gly Gln Asp Phe 
                85                  90                  95      


Gly Gln Pro Leu Pro Gly Pro Asp Ala Gln Ala Pro Glu Glu Leu Val 
            100                 105                 110         


Leu His Leu Ala Val Lys Val Ala Asn Gln Ala Ser Leu Pro Leu Val 
        115                 120                 125             


Asp Phe Ile Ile Gln Asn Gly Gly His Leu Asp Ala Lys Ala Ala Asp 
    130                 135                 140                 


Gly Asn Thr Ala Leu His Tyr Ala Ala Leu Tyr Asn Gln Pro Asp Cys 
145                 150                 155                 160 


Leu Lys Leu Leu Leu Lys Gly Arg Ala Leu Val Gly Thr Val Asn Glu 
                165                 170                 175     


Ala Gly Glu Thr Ala Leu Asp Ile Ala Arg Lys Lys His His Lys Glu 
            180                 185                 190         


Cys Glu Glu Leu Leu Glu Gln Ala Gln Ala Gly Thr Phe Ala Phe Pro 
        195                 200                 205             


Leu His Val Asp Tyr Ser Trp Val Ile Ser Thr Glu Pro Gly Ser Asp 
    210                 215                 220                 


Ser Glu Glu Asp Glu Glu Glu Lys Arg Cys Leu Leu Lys Leu Pro Ala 
225                 230                 235                 240 


Gln Ala His Trp Ala Ser Gly Arg Leu Asp Ile Ser Asn Lys Thr Tyr 
                245                 250                 255     


Glu Thr Val Ala Ser Leu Gly Ala Ala Thr Pro Gln Gly Glu Ser Glu 
            260                 265                 270         


Asp Cys Pro Pro Pro Leu Pro Val Lys Asn Ser Ser Arg Thr Leu Val 
        275                 280                 285             


Gln Gly Cys Ala Arg His Ala Ser Gly Gly Arg Arg Glu Glu Arg Ala 
    290                 295                 300                 


Arg Arg Glu 
305         


<210> 8781
<211> 498
<212> PRT
<213> Homo sapiens

<400> 8781
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Ile Leu Val Lys Thr Met Ile 
        435                 440                 445             


Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu 
    450                 455                 460                 


Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Thr Lys Gln Gly Ser Glu 
465                 470                 475                 480 


Asp Asn Leu Gln Gly Thr Asp Pro Pro Pro Val Gly Glu Glu Glu Val 
                485                 490                 495     


Leu Leu 
        


<210> 8782
<211> 199
<212> PRT
<213> Homo sapiens

<400> 8782
Met Thr Pro Leu Ala Pro Trp Asp Pro Lys Tyr Glu Ala Lys Ala Gly 
1               5                   10                  15      


Pro Arg Pro Val Trp Gly Ala Asn Cys Ser Ser Gly Ala Ser Phe Ser 
            20                  25                  30          


Gly Arg Thr Leu Cys His Pro Ser Phe Trp Pro Leu Tyr Glu Ala Ala 
        35                  40                  45              


Ser Gly Arg Gly Leu Arg Pro Val Ala Pro Ala Thr Gly His Trp Asn 
    50                  55                  60                  


Gly Gln Gln Ala Pro Pro Asp Ala Gly Phe Pro Val Val Cys Cys Glu 
65                  70                  75                  80  


Asp Val Phe Leu Ser Asp Pro Leu Leu Pro Arg Gly Gln Arg Val Pro 
                85                  90                  95      


Leu Tyr Leu Ser Lys Ala Pro Gln Gln Met Met Gly Ser Leu Lys Leu 
            100                 105                 110         


Leu Pro Pro Pro Pro Ile Met Ser Ala Arg Val Leu Pro Arg Pro Ser 
        115                 120                 125             


Pro Ser Arg Gly Pro Ser Thr Ala Trp Leu Ser Gly Pro Glu Leu Ile 
    130                 135                 140                 


Ala Leu Thr Gly Leu Leu Gln Met Ser Gln Gly Glu Pro Arg Pro Ser 
145                 150                 155                 160 


Ser Ser Ala Val Gly Pro Pro Asp His Thr Ser Asp Pro Pro Ser Pro 
                165                 170                 175     


Cys Gly Ser Pro Ser Ser Ser Gln Gly Ala Asp Leu Ser Leu Pro Gln 
            180                 185                 190         


Thr Pro Asp Thr His Cys Pro 
        195                 


<210> 8783
<211> 415
<212> PRT
<213> Homo sapiens

<400> 8783
Met Trp Arg Lys Val Tyr Thr Pro Arg Ser Ser Phe Glu Leu Ser Ala 
1               5                   10                  15      


Gln Pro Pro Ser Trp Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met 
            20                  25                  30          


Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala 
        35                  40                  45              


Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu 
    50                  55                  60                  


Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Asp Ser 
65                  70                  75                  80  


Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly 
                85                  90                  95      


Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys Ile Ala Leu Leu 
            100                 105                 110         


Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg 
        115                 120                 125             


Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn 
    130                 135                 140                 


Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser Gly Ala Lys Val 
145                 150                 155                 160 


Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala 
                165                 170                 175     


Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys 
            180                 185                 190         


Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala 
        195                 200                 205             


Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln 
    210                 215                 220                 


Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys 
225                 230                 235                 240 


Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu 
                245                 250                 255     


Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile 
            260                 265                 270         


Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu 
        275                 280                 285             


Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln 
    290                 295                 300                 


Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln 
305                 310                 315                 320 


Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu 
                325                 330                 335     


Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly Val Asp Ile Asn 
            340                 345                 350         


Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala 
        355                 360                 365             


Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu 
    370                 375                 380                 


Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp 
385                 390                 395                 400 


Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His 
                405                 410                 415 


<210> 8784
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 8784
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Ala Phe Thr Glu 
            100                 105                 110         


Thr Lys Gly Asn Val Ile Cys Leu Gly Lys Glu Val Phe Lys Gly Lys 
        115                 120                 125             


Lys Pro Asp Lys Asp Asn Arg Cys Arg Tyr Ile Leu Lys Thr Lys Phe 
    130                 135                 140                 


Arg Glu Met Trp Lys Ser Trp Pro Gly Asp Ser Lys Glu Val Gln Val 
145                 150                 155                 160 


Met Ala Glu Arg Tyr Lys Met Leu Ile Pro Phe Ser Asn Pro Arg Val 
                165                 170                 175     


Leu Pro Gly Pro Phe Ser Tyr Thr Val Val Leu Tyr Gly Pro Ala Gly 
            180                 185                 190         


Leu Gly Lys Thr Thr Leu Ala Gln Lys Leu Met Leu Asp Trp Ala Glu 
        195                 200                 205             


Asp Asn Leu Ile His Lys Phe Lys Tyr Ala Phe Tyr Leu Ser Cys Arg 
    210                 215                 220                 


Glu Leu Ser Arg Leu Gly Pro Cys Ser Phe Ala Glu Leu Val Phe Arg 
225                 230                 235                 240 


Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro His Ile Leu Ala Gln Ala 
                245                 250                 255     


Arg Lys Ile Leu Phe Val Ile Asp Gly Phe Asp Glu Leu Gly Ala Ala 
            260                 265                 270         


Pro Gly Ala Leu Ile Glu Asp Ile Cys Gly Asp Trp Glu Lys Lys Lys 
        275                 280                 285             


Pro Val Pro Val Leu Leu Gly Ser Leu Leu Asn Arg Val Met Leu Pro 
    290                 295                 300                 


Lys Ala Ala Leu Leu Val Thr Thr Arg Pro Arg Ala Leu Arg Asp Leu 
305                 310                 315                 320 


Arg Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val Glu Gly Phe Leu 
                325                 330                 335     


Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His Phe Gly Asp Glu Asp 
            340                 345                 350         


Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser Asn Ala Ala Leu Phe 
        355                 360                 365             


Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile Val Cys Thr Thr Leu 
    370                 375                 380                 


Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val Pro Thr Cys Leu Thr 
385                 390                 395                 400 


Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser Arg Phe Pro Gln Gly 
                405                 410                 415     


Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser Leu Leu Ala Ala Gln 
            420                 425                 430         


Gly Leu Trp Ala Gln Thr Ser Val Leu His Arg Glu Asp Leu Glu Arg 
        435                 440                 445             


Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe Leu Asp Gly Asp Ile 
    450                 455                 460                 


Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr Ser Phe Ile His Leu 
465                 470                 475                 480 


Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr Thr Leu Glu Lys Glu 
                485                 490                 495     


Glu Glu Glu Asp Arg Asp Gly His Thr Trp Asp Ile Gly Asp Val Gln 
            500                 505                 510         


Lys Leu Leu Ser Gly Val Glu Arg Leu Arg Asn Pro Asp Leu Ile Gln 
        515                 520                 525             


Ala Gly Tyr Tyr Ser Phe Gly Leu Ala Asn Glu Lys Arg Ala Lys Glu 
    530                 535                 540                 


Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro Asp Ile Lys Gln Glu 
545                 550                 555                 560 


Leu Leu Arg Cys Asp Ile Ser Cys Lys Gly Gly His Ser Thr Val Thr 
                565                 570                 575     


Asp Leu Gln Glu Leu Leu Gly Cys Leu Tyr Glu Ser Gln Glu Glu Glu 
            580                 585                 590         


Leu Val Lys Glu Val Met Ala Gln Phe Lys Glu Ile Ser Leu His Leu 
        595                 600                 605             


Asn Ala Val Asp Val Val Pro Ser Ser Phe Cys Val Lys His Cys Arg 
    610                 615                 620                 


Asn Leu Gln Lys Met Ser Leu Gln Val Ile Lys Glu Asn Leu Pro Glu 
625                 630                 635                 640 


Asn Val Thr Ala Ser Glu Ser Asp Ala Glu Val Glu Arg Ser Gln Asp 
                645                 650                 655     


Asp Gln His Met Leu Pro Phe Trp Thr Asp Leu Cys Ser Ile Phe Gly 
            660                 665                 670         


Ser Asn Lys Asp Leu Met Gly Leu Ala Ile Asn Asp Ser Phe Leu Ser 
        675                 680                 685             


Ala Ser Leu Val Arg Ile Leu Cys Glu Gln Ile Ala Ser Asp Thr Cys 
    690                 695                 700                 


His Leu Gln Arg Val Val Phe Lys Asn Ile Ser Pro Ala Asp Ala His 
705                 710                 715                 720 


Arg Asn Leu Cys Leu Ala Leu Arg Gly His Lys Thr Val Thr Tyr Leu 
                725                 730                 735     


Thr Leu Gln Gly Asn Asp Gln Asp Asp Met Phe Pro Ala Leu Cys Glu 
            740                 745                 750         


Val Leu Arg His Pro Glu Cys Asn Leu Arg Tyr Leu Gly Leu Val Ser 
        755                 760                 765             


Cys Ser Ala Thr Thr Gln Gln Trp Ala Asp Leu Ser Leu Ala Leu Glu 
    770                 775                 780                 


Val Asn Gln Ser Leu Thr Cys Val Asn Leu Ser Asp Asn Glu Leu Leu 
785                 790                 795                 800 


Asp Glu Gly Ala Lys Leu Leu Tyr Thr Thr Leu Arg His Pro Lys Cys 
                805                 810                 815     


Phe Leu Gln Arg Leu Ser Leu Glu Asn Cys His Leu Thr Glu Ala Asn 
            820                 825                 830         


Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Arg Glu Leu Thr His 
        835                 840                 845             


Leu Cys Leu Ala Lys Asn Pro Ile Gly Asn Thr Gly Val Lys Phe Leu 
    850                 855                 860                 


Cys Glu Gly Leu Arg Tyr Pro Glu Cys Lys Leu Gln Thr Leu Val Leu 
865                 870                 875                 880 


Trp Asn Cys Asp Ile Thr Ser Asp Gly Cys Cys Asp Leu Thr Lys Leu 
                885                 890                 895     


Leu Gln Glu Lys Ser Ser Leu Leu Cys Leu Asp Leu Gly Leu Asn His 
            900                 905                 910         


Ile Gly Val Lys Gly Met Lys Phe Leu Cys Glu Ala Leu Arg Lys Pro 
        915                 920                 925             


Leu Cys Asn Leu Arg Cys Leu Trp Leu Trp Gly Cys Ser Ile Pro Pro 
    930                 935                 940                 


Phe Ser Cys Glu Asp Leu Cys Ser Ala Leu Ser Cys Asn Gln Ser Leu 
945                 950                 955                 960 


Val Thr Leu Asp Leu Gly Gln Asn Pro Leu Gly Ser Ser Gly Val Lys 
                965                 970                 975     


Met Leu Phe Glu Thr Leu Thr Cys Ser Ser Gly Thr Leu Arg Thr Leu 
            980                 985                 990         


Arg Leu Lys Ile Asp Asp Phe Asn  Asp Glu Leu Asn Lys  Leu Leu Glu 
        995                 1000                 1005             


Glu Ile  Glu Glu Lys Asn Pro  Gln Leu Ile Ile Asp  Thr Glu Lys 
    1010                 1015                 1020             


His His  Pro Trp Ala Glu Arg  Pro Ser Ser His Asp  Phe Met Ile 
    1025                 1030                 1035             


<210> 8785
<211> 480
<212> PRT
<213> Homo sapiens

<400> 8785
Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Glu Phe Phe Ala Pro Trp Cys 
            20                  25                  30          


Gly His Cys Lys Arg Leu Ala Pro Glu Tyr Glu Ala Ala Ala Thr Arg 
        35                  40                  45              


Leu Lys Gly Ile Val Pro Leu Ala Lys Val Asp Cys Thr Ala Asn Thr 
    50                  55                  60                  


Asn Thr Cys Asn Lys Tyr Gly Val Ser Gly Tyr Pro Thr Leu Lys Ile 
65                  70                  75                  80  


Phe Arg Asp Gly Glu Glu Ala Gly Ala Tyr Asp Gly Pro Arg Thr Ala 
                85                  90                  95      


Asp Gly Ile Val Ser His Leu Lys Lys Gln Ala Gly Pro Ala Ser Val 
            100                 105                 110         


Pro Leu Arg Thr Glu Glu Glu Phe Lys Lys Phe Ile Ser Asp Lys Asp 
        115                 120                 125             


Ala Ser Ile Val Gly Phe Phe Asp Asp Ser Phe Ser Glu Ala His Ser 
    130                 135                 140                 


Glu Phe Leu Lys Ala Ala Ser Asn Leu Arg Asp Asn Tyr Arg Phe Ala 
145                 150                 155                 160 


His Thr Asn Val Glu Ser Leu Val Asn Glu Tyr Asp Asp Asn Gly Glu 
                165                 170                 175     


Gly Ile Ile Leu Phe Arg Pro Ser His Leu Thr Asn Lys Phe Glu Asp 
            180                 185                 190         


Lys Thr Val Ala Tyr Thr Glu Gln Lys Met Thr Ser Gly Lys Ile Lys 
        195                 200                 205             


Lys Phe Ile Gln Glu Asn Ile Phe Gly Ile Cys Pro His Met Thr Glu 
    210                 215                 220                 


Asp Asn Lys Asp Leu Ile Gln Gly Lys Asp Leu Leu Ile Ala Tyr Tyr 
225                 230                 235                 240 


Asp Val Asp Tyr Glu Lys Asn Ala Lys Gly Ser Asn Tyr Trp Arg Asn 
                245                 250                 255     


Arg Val Met Met Val Ala Lys Lys Phe Leu Asp Ala Gly His Lys Leu 
            260                 265                 270         


Asn Phe Ala Val Ala Ser Arg Lys Thr Phe Ser His Glu Leu Ser Asp 
        275                 280                 285             


Phe Gly Leu Glu Ser Thr Ala Gly Glu Ile Pro Val Val Ala Ile Arg 
    290                 295                 300                 


Thr Ala Lys Gly Glu Lys Phe Val Met Gln Glu Glu Phe Ser Arg Asp 
305                 310                 315                 320 


Gly Lys Ala Leu Glu Arg Phe Leu Gln Asp Tyr Phe Asp Gly Asn Leu 
                325                 330                 335     


Lys Arg Tyr Leu Lys Ser Glu Pro Ile Pro Glu Ser Asn Asp Gly Pro 
            340                 345                 350         


Val Lys Val Val Val Ala Glu Asn Phe Asp Glu Ile Val Asn Asn Glu 
        355                 360                 365             


Asn Lys Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
    370                 375                 380                 


Lys Asn Leu Glu Pro Lys Tyr Lys Glu Leu Gly Glu Lys Leu Ser Lys 
385                 390                 395                 400 


Asp Pro Asn Ile Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val 
                405                 410                 415     


Pro Ser Pro Tyr Glu Val Arg Gly Phe Pro Thr Ile Tyr Phe Ser Pro 
            420                 425                 430         


Ala Asn Lys Lys Leu Asn Pro Lys Lys Tyr Glu Gly Gly Arg Glu Leu 
        435                 440                 445             


Ser Asp Phe Ile Ser Tyr Leu Gln Arg Glu Ala Thr Asn Pro Pro Val 
    450                 455                 460                 


Ile Gln Glu Glu Lys Pro Lys Lys Lys Lys Lys Ala Gln Glu Asp Leu 
465                 470                 475                 480 


<210> 8786
<211> 75
<212> PRT
<213> Homo sapiens

<400> 8786
Met Gly Val Lys Leu Glu Ile Phe Arg Met Ile Ile Tyr Leu Thr Phe 
1               5                   10                  15      


Pro Val Ala Met Phe Trp Val Ser Asn Gln Ala Glu Trp Phe Glu Asp 
            20                  25                  30          


Asp Val Ile Gln Arg Lys Arg Glu Leu Trp Pro Pro Glu Lys Leu Gln 
        35                  40                  45              


Glu Leu Glu Glu Phe Lys Glu Arg Leu Arg Lys Arg Lys Arg Arg Glu 
    50                  55                  60                  


Glu Lys Leu Leu Arg Asp Ala Gln Gln Asn Ser 
65                  70                  75  


<210> 8787
<211> 268
<212> PRT
<213> Homo sapiens

<400> 8787
Met Gly Ser Ala Lys Ser Val Pro Val Thr Pro Ala Arg Pro Pro Pro 
1               5                   10                  15      


His Asn Lys His Leu Ala Arg Val Ala Asp Pro Arg Ser Pro Ser Ala 
            20                  25                  30          


Gly Ile Leu Arg Thr Pro Ile Gln Val Glu Ser Ser Pro Gln Pro Gly 
        35                  40                  45              


Leu Pro Ala Gly Glu Gln Leu Glu Gly Leu Lys His Ala Gln Asp Ser 
    50                  55                  60                  


Asp Pro Arg Ser Pro Thr Leu Gly Ile Ala Arg Thr Pro Met Lys Thr 
65                  70                  75                  80  


Ser Ser Gly Asp Pro Pro Ser Pro Leu Val Lys Gln Leu Ser Glu Val 
                85                  90                  95      


Phe Glu Thr Glu Asp Ser Lys Ser Asn Leu Pro Pro Glu Pro Val Leu 
            100                 105                 110         


Pro Pro Glu Ala Pro Leu Ser Ser Glu Leu Asp Leu Pro Leu Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Glu Glu Gln Met Pro Pro Trp Asn Gln Thr Glu Phe 
    130                 135                 140                 


Pro Ser Lys Gln Val Phe Ser Lys Glu Glu Ala Arg Gln Pro Thr Glu 
145                 150                 155                 160 


Thr Pro Val Ala Ser Gln Ser Ser Asp Lys Pro Ser Arg Asp Pro Glu 
                165                 170                 175     


Thr Pro Arg Ser Ser Gly Ser Met Arg Asn Arg Trp Lys Pro Asn Ser 
            180                 185                 190         


Ser Lys Val Leu Gly Arg Ser Pro Leu Thr Ile Leu Gln Asp Asp Asn 
        195                 200                 205             


Ser Pro Gly Thr Leu Thr Leu Arg Gln Gly Lys Arg Pro Ser Pro Leu 
    210                 215                 220                 


Ser Glu Asn Val Ser Glu Leu Lys Glu Gly Ala Ile Leu Gly Thr Gly 
225                 230                 235                 240 


Arg Leu Leu Lys Thr Gly Gly Arg Ala Trp Glu Gln Gly Gln Asp His 
                245                 250                 255     


Asp Lys Glu Asn Gln His Phe Pro Leu Val Glu Ser 
            260                 265             


<210> 8788
<211> 116
<212> PRT
<213> Homo sapiens

<400> 8788
Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly Leu Phe Arg Val Ala 
1               5                   10                  15      


Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala Ala Leu Asp Cys Cys 
            20                  25                  30          


Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro His Ala Ile Ala Gly 
        35                  40                  45              


Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro Leu Met Thr Phe 
    50                  55                  60                  


Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn Val Gln Glu Gln Asp 
65                  70                  75                  80  


Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu Lys Leu Pro Lys Ala 
                85                  90                  95      


Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe Tyr Pro Ser Cys Gln 
            100                 105                 110         


Asn Ile Lys Met 
        115     


<210> 8789
<211> 301
<212> PRT
<213> Homo sapiens

<400> 8789
Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Ile Lys Arg Glu Asn Glu Glu Asp 
    290                 295                 300     


<210> 8790
<211> 355
<212> PRT
<213> Homo sapiens

<400> 8790
Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg 
1               5                   10                  15      


Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu 
            20                  25                  30          


Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys 
        35                  40                  45              


Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr 
    50                  55                  60                  


Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu 
65                  70                  75                  80  


Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu 
                85                  90                  95      


Ala Glu Ser Val Ser Thr Leu Ala Glu Leu Lys Ile Val Ala Asp Gln 
            100                 105                 110         


Leu Cys Ala Lys Tyr Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn 
        115                 120                 125             


Gln Ile Gly Thr Val Asn Asp Arg Leu Met His Lys Leu Ser Val Glu 
    130                 135                 140                 


Ala Pro Pro Lys Ile Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys 
145                 150                 155                 160 


Asn Tyr Asn Val Pro Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala 
                165                 170                 175     


Pro Pro Gly Val Glu Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp 
            180                 185                 190         


Val Lys Lys Gly Gly Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala 
        195                 200                 205             


Pro Val Gly Gly Pro Asp Gly Thr Val Pro Met Pro Met Pro Met Pro 
    210                 215                 220                 


Met Pro Met Pro Ser Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys 
225                 230                 235                 240 


Gly Pro Ser Asp Phe Asn Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe 
                245                 250                 255     


Pro Asn Ile His Pro Pro Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu 
            260                 265                 270         


Ser Val Asp Asp Ile Asn Ala Asp Lys Asn Ile Ser Ser Ala Gln Ile 
        275                 280                 285             


Val Gly Pro Gly Pro Lys Pro Glu Ala Ser Ala Lys Leu Pro Ser Arg 
    290                 295                 300                 


Pro Ala Asp Asn Tyr Asp Asn Phe Val Leu Pro Glu Leu Pro Ser Val 
305                 310                 315                 320 


Pro Asp Thr Leu Pro Thr Ala Ser Ala Gly Ala Ser Thr Ser Ala Ser 
                325                 330                 335     


Glu Asp Ile Asp Phe Asp Asp Leu Ser Arg Arg Phe Glu Glu Leu Lys 
            340                 345                 350         


Lys Lys Thr 
        355 


<210> 8791
<211> 724
<212> PRT
<213> Homo sapiens

<400> 8791
Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
1               5                   10                  15      


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
            20                  25                  30          


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
        35                  40                  45              


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
    50                  55                  60                  


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
65                  70                  75                  80  


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
                85                  90                  95      


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
            100                 105                 110         


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
        115                 120                 125             


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
    130                 135                 140                 


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
145                 150                 155                 160 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
                165                 170                 175     


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
            180                 185                 190         


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
        195                 200                 205             


Ser Lys Phe Met Lys Asn Lys Ile Gly Gln Val Lys Gln Glu Leu Ser 
    210                 215                 220                 


Arg Lys Asp Thr Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu 
225                 230                 235                 240 


Thr Asn Gln Phe Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu 
                245                 250                 255     


Ser Leu Thr Ala Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val 
            260                 265                 270         


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
        275                 280                 285             


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
    290                 295                 300                 


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
305                 310                 315                 320 


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
                325                 330                 335     


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
            340                 345                 350         


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
        355                 360                 365             


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
    370                 375                 380                 


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
385                 390                 395                 400 


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
                405                 410                 415     


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
            420                 425                 430         


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
        435                 440                 445             


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
    450                 455                 460                 


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
465                 470                 475                 480 


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
                485                 490                 495     


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
            500                 505                 510         


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
        515                 520                 525             


Glu Leu Glu Ser Leu Thr Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
    530                 535                 540                 


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
545                 550                 555                 560 


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
                565                 570                 575     


Ser Gln Gln Leu Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val 
            580                 585                 590         


Lys Gln Glu Leu Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln 
        595                 600                 605             


Ser Leu Ala Glu Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg 
    610                 615                 620                 


Arg Lys His Leu Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu 
625                 630                 635                 640 


Ala Ala Ile Ser Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser 
                645                 650                 655     


Ser Ser Lys Lys Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu 
            660                 665                 670         


Lys Asp Arg Leu Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met 
        675                 680                 685             


Lys Leu Met Ala Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His 
    690                 695                 700                 


Ser Asn Gln Thr Asn His Lys Pro Ser Pro Asp Gln Asp Glu Glu Glu 
705                 710                 715                 720 


Gly Ile Trp Ala 
                


<210> 8792
<211> 135
<212> PRT
<213> Homo sapiens

<400> 8792
Met Ala Ile Gly Phe Asn Val Glu Thr Val Thr Tyr Lys Asn Leu Lys 
1               5                   10                  15      


Phe Gln Val Trp Asp Leu Gly Gly Gln Thr Ser Ile Arg Pro Tyr Trp 
            20                  25                  30          


Arg Cys Tyr Tyr Ser Asn Thr Asp Ala Val Ile Tyr Val Val Asp Ser 
        35                  40                  45              


Cys Asp Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met 
    50                  55                  60                  


Leu Glu Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn 
65                  70                  75                  80  


Lys Gln Asp Met Glu Gln Ala Met Thr Ser Ser Glu Met Ala Asn Ser 
                85                  90                  95      


Leu Gly Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Thr 
            100                 105                 110         


Ser Ala Thr Lys Gly Thr Gly Leu Asp Glu Ala Met Glu Trp Leu Val 
        115                 120                 125             


Glu Thr Leu Lys Ser Arg Gln 
    130                 135 


<210> 8793
<211> 227
<212> PRT
<213> Homo sapiens

<400> 8793
Arg Arg Gln Ile Leu Lys Glu Leu Ala Leu Cys Leu Arg Arg Gln Glu 
1               5                   10                  15      


Met Tyr Gly Pro Arg Ala Ala Ser Arg Asn Lys Glu Thr Ser Ala Gly 
            20                  25                  30          


Pro Val Ala Val Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro 
        35                  40                  45              


Ser Gly Ala Asn Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala 
    50                  55                  60                  


Leu Lys Tyr His Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys 
65                  70                  75                  80  


Phe Lys Glu Ile Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys 
                85                  90                  95      


Arg Gly Leu Tyr Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly 
            100                 105                 110         


Gly Thr Ser Gly Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly 
        115                 120                 125             


Asp Pro His Ala Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe 
    130                 135                 140                 


Asp Ile Phe Phe Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe 
145                 150                 155                 160 


Asp Pro Asp Asp Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala 
                165                 170                 175     


Phe Gly Arg Phe Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala 
            180                 185                 190         


Pro Glu Pro Leu Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val 
        195                 200                 205             


His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys 
    210                 215                 220                 


Arg Met Lys 
225         


<210> 8794
<211> 83
<212> PRT
<213> Homo sapiens

<400> 8794
Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala 
            


<210> 8795
<211> 213
<212> PRT
<213> Homo sapiens

<400> 8795
Met Asp Met Leu Gly Gly Pro Gly Ile Glu Ser Gln Cys Arg Lys Val 
1               5                   10                  15      


Asp Ile Ile Ala Asp Ala Ala Tyr Ser Ile Phe Gln Lys Pro Lys Ser 
            20                  25                  30          


Phe Thr Gly Asn Phe Val Ile Asp Glu Asn Ile Leu Lys Glu Glu Gly 
        35                  40                  45              


Ile Glu Asn Phe Asp Val Tyr Ala Ile Lys Pro Gly His Pro Leu Gln 
    50                  55                  60                  


Pro Asp Phe Phe Leu Asp Glu Tyr Pro Glu Ala Val Ser Lys Lys Val 
65                  70                  75                  80  


Glu Ser Thr Gly Ala Val Pro Glu Phe Lys Glu Glu Lys Leu Gln Leu 
                85                  90                  95      


Gln Pro Lys Pro Arg Ser Gly Ala Val Glu Glu Thr Phe Arg Ile Val 
            100                 105                 110         


Lys Asp Ser Leu Ser Asp Asp Val Val Lys Ala Thr Gln Ala Ile Tyr 
        115                 120                 125             


Leu Phe Glu Leu Ser Gly Glu Asp Gly Gly Thr Trp Phe Leu Asp Leu 
    130                 135                 140                 


Lys Ser Lys Gly Gly Asn Val Gly Tyr Gly Glu Pro Ser Asp Gln Ala 
145                 150                 155                 160 


Asp Val Val Met Ser Met Thr Thr Asp Asp Phe Val Lys Met Phe Ser 
                165                 170                 175     


Gly Lys Leu Lys Pro Thr Met Ala Phe Met Ser Gly Lys Leu Lys Ile 
            180                 185                 190         


Lys Gly Asn Met Ala Leu Ala Ile Lys Leu Glu Lys Leu Met Asn Gln 
        195                 200                 205             


Met Asn Ala Arg Leu 
    210             


<210> 8796
<211> 409
<212> PRT
<213> Homo sapiens

<400> 8796
Met Asn Arg Thr Trp Pro Arg Arg Ile Trp Gly Ser Ser Gln Asp Glu 
1               5                   10                  15      


Pro Glu Phe Ala Ser Ser Val Arg Arg Pro His Leu Thr Ser Asp Ala 
            20                  25                  30          


Val Ala Leu Leu Arg Asp Asn Val Thr Pro Arg Glu Asn Glu Leu Trp 
        35                  40                  45              


Thr Ser Leu Gly Asp Ser Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro 
    50                  55                  60                  


Glu Glu Gly Pro Pro Tyr Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro 
65                  70                  75                  80  


Pro Val Thr Asp Pro Gln Ser Arg Ala Trp Glu Asp Pro Val Glu Lys 
                85                  90                  95      


Gln Leu Gln His Glu Arg Arg Arg Arg Gln Val Thr Gln Ala Thr Gln 
            100                 105                 110         


Gln Gly Arg Gly Trp Glu Val Arg Gly Arg Gly Arg Ser Ala Trp Pro 
        115                 120                 125             


Arg Leu Thr Arg Leu Ser Tyr Phe Leu Gln Gln Ser Ala Pro Gln Val 
    130                 135                 140                 


Ala Val Asn Gly His Arg Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu 
145                 150                 155                 160 


Glu Ser Glu Thr Ala Gly Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln 
                165                 170                 175     


Ala Arg Asn Ser Ser Glu Leu Ser Val Lys Gln Arg Asp Val Leu Glu 
            180                 185                 190         


Val Leu Asp Asp Ser Arg Lys Trp Trp Lys Val Arg Asp Pro Ala Gly 
        195                 200                 205             


Gln Glu Gly Tyr Val Pro Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro 
    210                 215                 220                 


Arg Leu His His Ser Gln Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Ala Pro Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg 
                245                 250                 255     


Pro Arg Trp Asp Arg Pro Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly 
            260                 265                 270         


Leu Asp Pro Ser Glu Lys Glu Lys Phe Ser Gln Met Leu Ile Val Asn 
        275                 280                 285             


Glu Glu Leu Gln Ala Arg Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg 
    290                 295                 300                 


Ala Val Pro Gly Pro Arg Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser 
305                 310                 315                 320 


Asp Ala Ser Glu Val Arg Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser 
                325                 330                 335     


Gly Thr Val Asp Ala Leu Gly Val Leu Thr Gly Ala Gln Leu Phe Ser 
            340                 345                 350         


Leu Gln Lys Glu Glu Leu Arg Ala Val Ser Pro Glu Glu Gly Ala Arg 
        355                 360                 365             


Val Tyr Ser Gln Val Thr Val Gln Arg Ser Leu Leu Glu Asp Lys Glu 
    370                 375                 380                 


Lys Val Ser Glu Leu Glu Ala Val Met Glu Lys Gln Lys Lys Lys Val 
385                 390                 395                 400 


Glu Gly Glu Val Glu Met Glu Val Ile 
                405                 


<210> 8797
<211> 474
<212> PRT
<213> Homo sapiens

<400> 8797
Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg 
1               5                   10                  15      


Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala 
            20                  25                  30          


Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu 
        35                  40                  45              


Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro 
    50                  55                  60                  


Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln 
65                  70                  75                  80  


Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu 
                85                  90                  95      


Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu 
            100                 105                 110         


Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His 
        115                 120                 125             


Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His 
    130                 135                 140                 


Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly 
                165                 170                 175     


Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro 
            180                 185                 190         


Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp 
        195                 200                 205             


Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala 
    210                 215                 220                 


Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile 
225                 230                 235                 240 


Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu 
                245                 250                 255     


Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly 
            260                 265                 270         


Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu 
        275                 280                 285             


Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile 
    290                 295                 300                 


Gln Asn Met Pro Asn Val Arg Asp His Asp Ala Ser Val Tyr Leu Arg 
305                 310                 315                 320 


Leu Gln Gly Asp Ala Leu Ser Val Gly Gly Tyr Glu Ala Asn Pro Ile 
                325                 330                 335     


Phe Trp Glu Glu Val Ser Asp Lys Phe Ala Phe Gly Leu Phe Asp Leu 
            340                 345                 350         


Asp Trp Glu Val Phe Thr Gln His Ile Glu Gly Ala Ile Asn Arg Val 
        355                 360                 365             


Pro Val Leu Glu Lys Thr Gly Ile Lys Ser Thr Val Cys Gly Pro Glu 
    370                 375                 380                 


Ser Phe Thr Pro Asp His Lys Pro Leu Met Gly Glu Ala Pro Glu Leu 
385                 390                 395                 400 


Arg Gly Phe Phe Leu Gly Cys Gly Phe Asn Ser Ala Gly Met Met Leu 
                405                 410                 415     


Gly Gly Gly Cys Gly Gln Glu Leu Ala His Trp Ile Ile His Gly Arg 
            420                 425                 430         


Pro Glu Lys Asp Met His Gly Tyr Asp Ile Arg Arg Phe His His Ser 
        435                 440                 445             


Leu Thr Asp His Pro Arg Trp Ile Arg Glu Arg Ser His Glu Ser Tyr 
    450                 455                 460                 


Gln Glu Leu Leu Arg Arg Leu Pro Pro Arg 
465                 470                 


<210> 8798
<211> 630
<212> PRT
<213> Homo sapiens

<400> 8798
Met Ser Ile Glu Leu Gln Ser Val Ser Asn Pro Val His Arg Lys Asp 
1               5                   10                  15      


Leu Val Ile Arg Leu Thr Asp Asp Thr Asp Pro Phe Phe Leu Tyr Asn 
            20                  25                  30          


Leu Val Ile Ser Glu Glu Asp Phe Gln Ser Leu Lys Phe Gln Gln Gly 
        35                  40                  45              


Leu Leu Val Asp Phe Leu Ala Phe Pro Gln Lys Phe Ile Asp Leu Leu 
    50                  55                  60                  


Gln Gln Cys Thr Gln Glu His Ala Lys Glu Ile Pro Arg Phe Leu Leu 
65                  70                  75                  80  


Gln Leu Val Ser Pro Ala Ala Ile Leu Asp Asn Ser Pro Ala Phe Leu 
                85                  90                  95      


Asn Val Val Glu Thr Asn Pro Phe Lys His Leu Thr His Leu Ser Leu 
            100                 105                 110         


Lys Leu Leu Pro Gly Asn Asp Val Glu Ile Lys Lys Phe Leu Ala Gly 
        115                 120                 125             


Cys Leu Lys Cys Ser Lys Glu Glu Lys Leu Ser Leu Met Gln Ser Leu 
    130                 135                 140                 


Asp Asp Ala Thr Lys Gln Leu Asp Phe Thr Arg Lys Thr Leu Ala Glu 
145                 150                 155                 160 


Lys Lys Gln Glu Leu Asp Lys Leu Arg Asn Glu Trp Ala Ser His Thr 
                165                 170                 175     


Ala Ala Leu Thr Asn Lys His Ser Gln Glu Leu Thr Asn Glu Lys Glu 
            180                 185                 190         


Lys Ala Leu Gln Ala Gln Val Gln Tyr Gln Gln Gln His Glu Gln Gln 
        195                 200                 205             


Lys Lys Asp Leu Glu Ile Leu His Gln Gln Asn Ile His Gln Leu Gln 
    210                 215                 220                 


Asn Arg Leu Ser Glu Leu Glu Ala Ala Asn Lys Asp Leu Thr Glu Arg 
225                 230                 235                 240 


Lys Tyr Lys Gly Asp Ser Thr Ile Arg Glu Leu Lys Ala Lys Leu Ser 
                245                 250                 255     


Gly Val Glu Glu Glu Leu Gln Arg Thr Lys Gln Glu Val Leu Ser Leu 
            260                 265                 270         


Arg Arg Glu Asn Ser Thr Leu Asp Val Glu Cys His Glu Lys Glu Lys 
        275                 280                 285             


His Val Asn Gln Leu Gln Thr Lys Val Ala Val Leu Glu Gln Glu Ile 
    290                 295                 300                 


Lys Asp Lys Asp Gln Leu Val Leu Arg Thr Lys Glu Ala Phe Asp Thr 
305                 310                 315                 320 


Ile Gln Glu Gln Lys Val Val Leu Glu Glu Asn Gly Glu Lys Asn Gln 
                325                 330                 335     


Val Gln Leu Gly Lys Leu Glu Ala Thr Ile Lys Ser Leu Ser Ala Glu 
            340                 345                 350         


Leu Leu Lys Ala Asn Glu Ile Ile Lys Lys Leu Gln Gly Asp Leu Lys 
        355                 360                 365             


Thr Leu Met Gly Lys Leu Lys Leu Lys Asn Thr Val Thr Ile Gln Gln 
    370                 375                 380                 


Glu Lys Leu Leu Ala Glu Lys Glu Glu Lys Leu Gln Lys Glu Gln Lys 
385                 390                 395                 400 


Glu Leu Gln Asp Val Gly Gln Ser Leu Arg Ile Lys Glu Gln Glu Val 
                405                 410                 415     


Cys Lys Leu Gln Glu Gln Leu Glu Ala Thr Val Lys Lys Leu Glu Glu 
            420                 425                 430         


Ser Lys Gln Leu Leu Lys Asn Asn Glu Lys Leu Ile Thr Trp Leu Asn 
        435                 440                 445             


Lys Glu Leu Asn Glu Asn Gln Leu Val Arg Lys Gln Asp Val Leu Gly 
    450                 455                 460                 


Pro Ser Thr Thr Pro Pro Ala His Ser Ser Ser Asn Thr Ile Arg Ser 
465                 470                 475                 480 


Gly Ile Ser Pro Asn Leu Asn Val Val Asp Gly Arg Leu Thr Tyr Pro 
                485                 490                 495     


Thr Cys Gly Ile Gly Tyr Pro Val Ser Ser Ala Phe Ala Phe Gln Asn 
            500                 505                 510         


Thr Phe Pro His Ser Ile Ser Ala Lys Asn Thr Ser His Pro Gly Ser 
        515                 520                 525             


Gly Thr Lys Val Gln Phe Asn Leu Gln Phe Thr Lys Pro Asn Ala Ser 
    530                 535                 540                 


Leu Gly Asp Val Gln Ser Gly Ala Thr Ile Ser Met Pro Cys Ser Thr 
545                 550                 555                 560 


Asp Lys Glu Asn Gly Glu Asn Val Gly Leu Glu Ser Lys Tyr Leu Lys 
                565                 570                 575     


Lys Arg Glu Asp Ser Ile Pro Leu Arg Gly Leu Ser Gln Asn Leu Phe 
            580                 585                 590         


Ser Asn Ser Asp His Gln Arg Asp Gly Thr Leu Gly Ala Leu His Thr 
        595                 600                 605             


Ser Ser Lys Pro Thr Ala Leu Pro Ser Ala Ser Ser Ala Tyr Phe Pro 
    610                 615                 620                 


Gly Gln Leu Pro Asn Ser 
625                 630 


<210> 8799
<211> 389
<212> PRT
<213> Homo sapiens

<400> 8799
Met Asp Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg Thr 
1               5                   10                  15      


Lys Val His Ala Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val Asp 
            20                  25                  30          


Ser Ile Leu Ala Ile Lys Lys Gln Asp Glu Pro Ile Asp Leu Phe Met 
        35                  40                  45              


Ile Glu Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser Leu 
    50                  55                  60                  


Ile Arg Gly Leu Val Leu Asp His Gly Ala Arg His Pro Asp Met Lys 
65                  70                  75                  80  


Lys Arg Val Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu Glu 
                85                  90                  95      


Tyr Glu Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala Glu 
            100                 105                 110         


Glu Arg Glu Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp Arg 
        115                 120                 125             


Val Lys Lys Ile Ile Glu Leu Lys Arg Lys Val Cys Gly Asp Ser Asp 
    130                 135                 140                 


Lys Gly Phe Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser Leu 
145                 150                 155                 160 


Asp Ala Leu Ser Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys Arg 
                165                 170                 175     


Arg Asn Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Val Ala Leu Asn 
            180                 185                 190         


Ser Phe Asp Asp Leu Ser Pro Asp Cys Leu Gly His Ala Gly Leu Val 
        195                 200                 205             


Tyr Glu Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys Cys 
    210                 215                 220                 


Asn Asn Pro Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn Lys His 
225                 230                 235                 240 


Thr Leu Thr Gln Ile Lys Asp Ala Val Arg Asp Gly Leu Arg Ala Val 
                245                 250                 255     


Lys Asn Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala Val 
            260                 265                 270         


Glu Val Ala Met Ala Glu Ala Leu Ile Lys His Lys Pro Ser Val Lys 
        275                 280                 285             


Gly Arg Ala Gln Leu Gly Val Gln Ala Phe Ala Asp Ala Leu Leu Ile 
    290                 295                 300                 


Ile Pro Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu Thr 
305                 310                 315                 320 


Leu Val Lys Ile Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val Gly 
                325                 330                 335     


Val Asp Leu Asn Thr Gly Glu Pro Met Val Ala Ala Glu Val Gly Val 
            340                 345                 350         


Trp Asp Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr Val 
        355                 360                 365             


Ile Ala Thr Asn Ile Leu Leu Val Asp Glu Ile Met Arg Ala Gly Met 
    370                 375                 380                 


Ser Ser Leu Lys Gly 
385                 


<210> 8800
<211> 146
<212> PRT
<213> Homo sapiens

<400> 8800
Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu Ala Pro Glu Gly 
1               5                   10                  15      


Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr Leu Leu Thr Ile 
            20                  25                  30          


Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg Ile Glu Tyr Gln 
        35                  40                  45              


Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val Lys Ser Lys Leu 
    50                  55                  60                  


Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr Tyr Val Gln Met 
65                  70                  75                  80  


Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg Asn Gly Thr Val 
                85                  90                  95      


His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala Pro Ser Leu Gln 
            100                 105                 110         


His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly Ala Ile Trp Gly 
        115                 120                 125             


Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu Glu Tyr Lys Phe 
    130                 135                 140                 


Gln Val 
145     


<210> 8801
<211> 634
<212> PRT
<213> Homo sapiens

<400> 8801
Met Leu Glu Tyr Ala Leu Lys Gln Glu Arg Ala Lys Tyr His Lys Leu 
1               5                   10                  15      


Lys Phe Gly Thr Asp Leu Asn Gln Gly Glu Lys Lys Ala Asp Val Ser 
            20                  25                  30          


Glu Gln Val Ser Asn Gly Pro Val Glu Ser Val Thr Leu Glu Asn Ser 
        35                  40                  45              


Pro Leu Val Trp Lys Glu Gly Arg Gln Leu Leu Arg Gln Tyr Leu Glu 
    50                  55                  60                  


Glu Val Gly Tyr Thr Asp Thr Ile Leu Asp Met Arg Ser Lys Arg Val 
65                  70                  75                  80  


Arg Ser Leu Leu Gly Arg Ser Leu Glu Leu Asn Gly Ala Val Glu Pro 
                85                  90                  95      


Ser Glu Gly Ala Pro Arg Ala Pro Pro Gly Pro Ala Gly Leu Ser Gly 
            100                 105                 110         


Gly Glu Ser Leu Leu Val Lys Gln Ile Glu Glu Gln Ile Lys Arg Asn 
        115                 120                 125             


Ala Ala Gly Lys Asp Gly Lys Glu Arg Leu Gly Gly Ser Val Leu Gly 
    130                 135                 140                 


Gln Ile Pro Phe Leu Gln Asn Cys Glu Asp Glu Asp Ser Asp Glu Asp 
145                 150                 155                 160 


Asp Glu Leu Asp Ser Val Gln His Lys Lys Gln Arg Val Lys Leu Pro 
                165                 170                 175     


Ser Lys Ala Leu Val Pro Glu Met Glu Asp Glu Asp Glu Glu Asp Asp 
            180                 185                 190         


Ser Glu Asp Ala Ile Asn Glu Phe Asp Phe Leu Gly Ser Gly Glu Asp 
        195                 200                 205             


Gly Glu Gly Ala Pro Asp Pro Arg Arg Cys Thr Val Asp Gly Ser Pro 
    210                 215                 220                 


His Glu Leu Glu Ser Arg Arg Val Lys Leu Gln Gly Ile Leu Ala Asp 
225                 230                 235                 240 


Leu Arg Asp Val Asp Gly Leu Pro Pro Lys Val Thr Gly Pro Pro Pro 
                245                 250                 255     


Gly Thr Pro Gln Pro Arg Pro His Glu Asp Val Phe Ile Met Asp Thr 
            260                 265                 270         


Ile Gly Gly Gly Glu Val Ser Leu Gly Asp Leu Ala Asp Leu Thr Val 
        275                 280                 285             


Thr Asn Asp Asn Asp Leu Ser Cys Asp Leu Ser Asp Ser Lys Asp Ala 
    290                 295                 300                 


Phe Lys Lys Thr Trp Asn Pro Lys Phe Thr Leu Arg Ser His Tyr Asp 
305                 310                 315                 320 


Gly Ile Arg Ser Leu Ala Phe His His Ser Gln Ser Ala Leu Leu Thr 
                325                 330                 335     


Ala Ser Glu Asp Gly Thr Leu Lys Leu Trp Asn Leu Gln Lys Ala Val 
            340                 345                 350         


Thr Ala Lys Lys Asn Ala Ala Leu Asp Val Glu Pro Ile His Ala Phe 
        355                 360                 365             


Arg Ala His Arg Gly Pro Val Leu Ala Val Ala Met Gly Ser Asn Ser 
    370                 375                 380                 


Glu Tyr Cys Tyr Ser Gly Gly Ala Asp Ala Cys Ile His Ser Trp Lys 
385                 390                 395                 400 


Ile Pro Asp Leu Ser Met Asp Pro Tyr Asp Gly Tyr Asp Pro Ser Val 
                405                 410                 415     


Leu Ser His Val Leu Glu Gly His Gly Asp Ala Val Trp Gly Leu Ala 
            420                 425                 430         


Phe Ser Pro Thr Ser Gln Arg Leu Ala Ser Cys Ser Ala Asp Gly Thr 
        435                 440                 445             


Val Arg Ile Trp Asp Pro Ser Ser Ser Ser Pro Ala Cys Leu Cys Thr 
    450                 455                 460                 


Phe Pro Thr Ala Ser Glu His Gly Val Pro Thr Ser Val Ala Phe Thr 
465                 470                 475                 480 


Ser Thr Glu Pro Ala His Ile Val Ala Ser Phe Arg Ser Gly Asp Thr 
                485                 490                 495     


Val Leu Tyr Asp Met Glu Val Gly Ser Ala Leu Leu Thr Leu Glu Ser 
            500                 505                 510         


Arg Gly Ser Ser Gly Pro Thr Gln Ile Asn Gln Val Val Ser His Pro 
        515                 520                 525             


Asn Gln Pro Leu Thr Ile Thr Ala His Asp Asp Arg Gly Ile Arg Phe 
    530                 535                 540                 


Leu Asp Asn Arg Thr Gly Lys Pro Val His Ser Met Val Ala His Leu 
545                 550                 555                 560 


Asp Ala Val Thr Cys Leu Ala Val Asp Pro Asn Gly Ala Phe Leu Met 
                565                 570                 575     


Ser Gly Ser His Asp Cys Ser Leu Arg Leu Trp Ser Leu Asp Asn Lys 
            580                 585                 590         


Thr Cys Val Gln Glu Ile Thr Ala His Arg Lys Lys His Glu Glu Ala 
        595                 600                 605             


Ile His Ala Val Ala Cys His Pro Ser Lys Ala Leu Ile Ala Ser Ala 
    610                 615                 620                 


Gly Ala Asp Ala Leu Ala Lys Val Phe Val 
625                 630                 


<210> 8802
<211> 455
<212> PRT
<213> Homo sapiens

<400> 8802
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala 
                325                 330                 335     


Arg Met Ser Glu Glu Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn 
            340                 345                 350         


Ser Ala Glu Met Ser Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly 
        355                 360                 365             


His Gly Met Asn Pro Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Phe Ser Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met 
385                 390                 395                 400 


Gln Ile Asn Met Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys 
                405                 410                 415     


Arg Arg Gly Lys Lys Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp 
            420                 425                 430         


Leu Ser Glu Gly Asp Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp 
        435                 440                 445             


Asn Asp Met Asp Asn Ser Glu 
    450                 455 


<210> 8803
<211> 157
<212> PRT
<213> Homo sapiens

<400> 8803
Met Lys Ser Met Ser Gln Leu Ala Val Leu Ser Arg Arg Trp Lys Pro 
1               5                   10                  15      


Ser Glu Met Lys Leu Asp Pro Phe Gln Glu Val Val Leu Glu Ser Ser 
            20                  25                  30          


Ser Val Asp Glu Leu Arg Glu Lys Leu Ser Glu Ile Ser Gly Ile Pro 
        35                  40                  45              


Leu Asp Asp Ile Glu Phe Ala Lys Gly Arg Gly Thr Phe Pro Cys Asp 
    50                  55                  60                  


Ile Ser Val Leu Asp Ile His Gln Asp Leu Asp Trp Asn Pro Lys Val 
65                  70                  75                  80  


Ser Thr Leu Asn Val Trp Pro Leu Tyr Ile Cys Asp Asp Gly Ala Val 
                85                  90                  95      


Ile Phe Tyr Arg Asp Lys Thr Glu Glu Leu Met Glu Leu Thr Asp Glu 
            100                 105                 110         


Gln Arg Asn Glu Leu Met Lys Lys Glu Ser Ser Arg Leu Gln Lys Thr 
        115                 120                 125             


Gly His Arg Val Thr Tyr Ser Pro Arg Lys Glu Lys Ala Leu Lys Ile 
    130                 135                 140                 


Tyr Leu Asp Gly Ala Pro Asn Lys Asp Leu Thr Gln Asp 
145                 150                 155         


<210> 8804
<211> 360
<212> PRT
<213> Homo sapiens

<400> 8804
Met Lys Ala Thr Ala Met Thr Ser Ala Trp Leu Ala Gln Gly Thr Gly 
1               5                   10                  15      


Glu Gly Val Asn Asp Val Arg Lys Gly Ala Cys Ala Ser His Val Ser 
            20                  25                  30          


Thr Met Ala Ser Phe Leu Lys Gly Ala His Val Thr Ile Asn Ala Arg 
        35                  40                  45              


Ala Glu Glu Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys 
    50                  55                  60                  


Ala Ser Gly Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln 
65                  70                  75                  80  


Asp Val Gly Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Thr Asn 
                85                  90                  95      


Ala Val Ser Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys 
            100                 105                 110         


Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala 
        115                 120                 125             


Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu 
    130                 135                 140                 


Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu 
145                 150                 155                 160 


Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln Gln Glu Val Val Ser Arg 
                165                 170                 175     


Asn Arg Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys 
            180                 185                 190         


Gln Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro 
        195                 200                 205             


Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu 
    210                 215                 220                 


Thr His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala 
225                 230                 235                 240 


Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val 
                245                 250                 255     


Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr 
            260                 265                 270         


Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu 
        275                 280                 285             


His Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu 
    290                 295                 300                 


Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile 
305                 310                 315                 320 


Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu 
                325                 330                 335     


Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro 
            340                 345                 350         


Ala Asn Tyr Val Glu Leu Ile Glu 
        355                 360 


<210> 8805
<211> 96
<212> PRT
<213> Homo sapiens

<400> 8805
Met Cys His Thr Ser Cys Ser Ser Gly Cys Gln Pro Ala Cys Cys Ala 
1               5                   10                  15      


Pro Ser Pro Cys Gln Pro Ala Cys Cys Val Pro Val Ser Cys Gln Ser 
            20                  25                  30          


Ser Val Cys Val Pro Val Ser Cys Arg Pro Ile Val Cys Ala Ala Pro 
        35                  40                  45              


Ser Cys Gln Ser Ser Leu Cys Val Pro Val Ser Cys Arg Pro Val Val 
    50                  55                  60                  


Tyr Ala Ala Pro Ser Cys Gln Ser Ser Gly Cys Cys Gln Pro Ser Cys 
65                  70                  75                  80  


Thr Ser Val Leu Cys Arg Pro Ile Ser Tyr Ser Ile Ser Ser Cys Cys 
                85                  90                  95      


<210> 8806
<211> 8
<212> PRT
<213> Homo sapiens

<400> 8806
Met Pro Leu Ser Ser Pro Asn Ala 
1               5               


<210> 8807
<211> 127
<212> PRT
<213> Homo sapiens

<400> 8807
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Thr Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Thr His Gly Thr Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Thr Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu Asp Gly Asn Arg Asp Thr Pro Leu His Trp Ala Ala Phe 
        115                 120                 125         


<210> 8808
<211> 105
<212> PRT
<213> Homo sapiens

<400> 8808
Gln Trp Thr Ala Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln 
1               5                   10                  15      


Pro Lys Lys Asp Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu 
            20                  25                  30          


Leu Lys Arg Glu Lys Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser 
        35                  40                  45              


Pro Trp Cys Gln Asn Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu 
    50                  55                  60                  


Ile Glu Pro His Asn Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln 
65                  70                  75                  80  


Pro Arg Thr Arg Ser Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys 
                85                  90                  95      


Lys Lys Thr Ser Glu Ser Gln Lys Gln 
            100                 105 


<210> 8809
<211> 371
<212> PRT
<213> Homo sapiens

<400> 8809
Met Glu Glu Glu Gly Leu Ala Asp Glu Glu Val Arg Leu Val Gln Lys 
1               5                   10                  15      


Lys Asp Thr Gly His Ile Tyr Ala Met Lys Ile Leu Arg Lys Ser Asp 
            20                  25                  30          


Met Leu Glu Lys Glu Gln Val Ala His Ile Arg Ala Glu Arg Asp Ile 
        35                  40                  45              


Leu Val Glu Ala Asp Gly Ala Trp Val Val Lys Met Phe Tyr Ser Phe 
    50                  55                  60                  


Gln Asp Lys Arg Asn Leu Tyr Leu Ile Met Glu Phe Leu Pro Gly Gly 
65                  70                  75                  80  


Asp Met Met Thr Leu Leu Met Lys Lys Asp Thr Leu Thr Glu Glu Glu 
                85                  90                  95      


Thr Gln Phe Tyr Ile Ser Glu Thr Val Leu Ala Ile Asp Ala Ile His 
            100                 105                 110         


Gln Leu Gly Phe Ile His Arg Asp Ile Lys Pro Asp Asn Leu Leu Leu 
        115                 120                 125             


Asp Ala Lys Gly His Val Lys Leu Ser Asp Phe Gly Leu Cys Thr Gly 
    130                 135                 140                 


Leu Lys Lys Ala His Arg Thr Glu Phe Tyr Arg Asn Leu Thr His Asn 
145                 150                 155                 160 


Pro Pro Ser Asp Phe Ser Phe Gln Asn Met Asn Ser Lys Arg Lys Ala 
                165                 170                 175     


Glu Thr Trp Lys Lys Asn Arg Arg Gln Leu Ala Tyr Ser Thr Val Gly 
            180                 185                 190         


Thr Pro Asp Tyr Ile Ala Pro Glu Val Phe Met Gln Thr Gly Tyr Asn 
        195                 200                 205             


Lys Leu Cys Asp Trp Trp Ser Leu Gly Val Ile Met Tyr Glu Met Leu 
    210                 215                 220                 


Ile Gly Tyr Pro Pro Phe Cys Ser Glu Thr Pro Gln Glu Thr Tyr Arg 
225                 230                 235                 240 


Lys Val Met Asn Trp Lys Glu Thr Leu Val Phe Pro Pro Glu Val Pro 
                245                 250                 255     


Ile Ser Glu Lys Ala Lys Asp Leu Ile Leu Arg Phe Cys Ile Asp Ser 
            260                 265                 270         


Glu Asn Arg Ile Gly Asn Ser Gly Val Glu Glu Ile Lys Gly His Pro 
        275                 280                 285             


Phe Phe Glu Gly Val Asp Trp Glu His Ile Arg Glu Arg Pro Ala Ala 
    290                 295                 300                 


Ile Pro Ile Glu Ile Lys Ser Ile Asp Asp Thr Ser Asn Phe Asp Asp 
305                 310                 315                 320 


Phe Pro Glu Ser Asp Ile Leu Gln Pro Val Pro Asn Thr Thr Glu Pro 
                325                 330                 335     


Asp Tyr Lys Ser Lys Asp Trp Val Phe Leu Asn Tyr Thr Tyr Lys Arg 
            340                 345                 350         


Phe Glu Gly Leu Thr Gln Arg Gly Ser Ile Pro Thr Tyr Met Lys Ala 
        355                 360                 365             


Gly Lys Leu 
    370     


<210> 8810
<211> 187
<212> PRT
<213> Homo sapiens

<400> 8810
Met Asn Asn Thr Leu Arg Lys Asp Gly Lys Lys Asp Cys Cys Phe Glu 
1               5                   10                  15      


Ile Ser Ala Pro Asp Lys Arg Ile Tyr Gln Phe Thr Ala Ala Ser Pro 
            20                  25                  30          


Lys Asp Ala Glu Glu Trp Val Gln Gln Leu Lys Phe Val Leu Gln Asp 
        35                  40                  45              


Met Glu Ser Asp Ile Ile Pro Glu Asp Tyr Asp Glu Arg Gly Glu Leu 
    50                  55                  60                  


Tyr Asp Asp Val Asp His Pro Leu Pro Ile Ser Asn Pro Leu Thr Ser 
65                  70                  75                  80  


Ser Gln Pro Ile Asp Asp Glu Ile Tyr Glu Glu Leu Pro Glu Glu Glu 
                85                  90                  95      


Glu Asp Ser Ala Pro Val Lys Val Glu Glu Gln Arg Lys Met Ser Gln 
            100                 105                 110         


Asp Ser Val His His Thr Ser Gly Asp Lys Ser Thr Asp Tyr Ala Asn 
        115                 120                 125             


Phe Tyr Gln Gly Leu Trp Asp Cys Thr Gly Ala Phe Ser Asp Glu Leu 
    130                 135                 140                 


Ser Phe Lys Arg Gly Asp Val Ile Tyr Ile Leu Ser Lys Glu Tyr Asn 
145                 150                 155                 160 


Arg Tyr Gly Trp Trp Val Gly Glu Met Lys Gly Ala Ile Gly Leu Val 
                165                 170                 175     


Pro Lys Ala Tyr Ile Met Glu Met Tyr Asp Ile 
            180                 185         


<210> 8811
<211> 72
<212> PRT
<213> Homo sapiens

<400> 8811
Met Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly 
            20                  25                  30          


Gln Cys Pro Trp Arg Gly Ala Gly Ser Phe Leu Asp Pro Glu Ile Lys 
        35                  40                  45              


Ala Phe Leu Glu Glu Asn Thr Glu Val Thr Ser Ser Gly Ser Leu Thr 
    50                  55                  60                  


Pro Glu Ile Gln Leu Arg Leu Leu 
65                  70          


<210> 8812
<211> 972
<212> PRT
<213> Homo sapiens

<400> 8812
Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu Leu Gly 
1               5                   10                  15      


Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu Glu Thr 
            20                  25                  30          


Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu Gln Ala 
        35                  40                  45              


Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala Ala Val 
    50                  55                  60                  


Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr Pro Ala 
65                  70                  75                  80  


Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Asn Leu Leu Pro Gly Phe 
                85                  90                  95      


Leu Gln Ala Val Asn Asp Ser Cys Tyr Gln Asn Asp Asp Ser Val Leu 
            100                 105                 110         


Lys Ser Leu Val Glu Ile Ala Asp Thr Val Pro Lys Tyr Leu Arg Pro 
        115                 120                 125             


His Leu Glu Ala Thr Leu Gln Leu Ser Leu Lys Leu Cys Gly Asp Thr 
    130                 135                 140                 


Ser Leu Asn Asn Met Gln Arg Gln Leu Ala Leu Glu Val Ile Val Thr 
145                 150                 155                 160 


Leu Ser Glu Thr Ala Ala Ala Met Leu Arg Lys His Thr Asn Ile Val 
                165                 170                 175     


Ala Gln Thr Ile Pro Gln Met Leu Ala Met Met Val Asp Leu Glu Glu 
            180                 185                 190         


Asp Glu Asp Trp Ala Asn Ala Asp Glu Leu Glu Asp Asp Asp Phe Asp 
        195                 200                 205             


Ser Asn Ala Val Ala Gly Glu Ser Ala Leu Asp Arg Met Ala Cys Gly 
    210                 215                 220                 


Leu Gly Gly Lys Leu Val Leu Pro Met Ile Lys Glu His Ile Met Gln 
225                 230                 235                 240 


Met Leu Gln Asn Pro Asp Trp Lys Tyr Arg His Ala Gly Leu Met Ala 
                245                 250                 255     


Leu Ser Ala Ile Gly Glu Gly Cys His Gln Gln Met Glu Gly Ile Leu 
            260                 265                 270         


Asn Glu Ile Val Asn Phe Val Leu Leu Phe Leu Gln Asp Pro His Pro 
        275                 280                 285             


Arg Val Arg Tyr Ala Ala Cys Asn Ala Val Gly Gln Met Ala Thr Asp 
    290                 295                 300                 


Phe Ala Pro Gly Phe Gln Lys Lys Phe His Glu Lys Val Ile Ala Ala 
305                 310                 315                 320 


Leu Leu Gln Thr Met Glu Asp Gln Gly Asn Gln Arg Val Gln Ala His 
                325                 330                 335     


Ala Ala Ala Ala Leu Ile Asn Phe Thr Glu Asp Cys Pro Lys Ser Leu 
            340                 345                 350         


Leu Ile Pro Tyr Leu Asp Asn Leu Val Lys His Leu His Ser Ile Met 
        355                 360                 365             


Val Leu Lys Leu Gln Glu Leu Ile Gln Lys Gly Thr Lys Leu Val Leu 
    370                 375                 380                 


Glu Gln Val Val Thr Ser Ile Ala Ser Val Ala Asp Thr Ala Glu Glu 
385                 390                 395                 400 


Lys Phe Val Pro Tyr Tyr Asp Leu Phe Met Pro Ser Leu Lys His Ile 
                405                 410                 415     


Val Glu Asn Ala Val Gln Lys Glu Leu Arg Leu Leu Arg Gly Lys Thr 
            420                 425                 430         


Ile Glu Cys Ile Ser Leu Ile Gly Leu Ala Val Gly Lys Glu Lys Phe 
        435                 440                 445             


Met Gln Asp Ala Ser Asp Val Met Gln Leu Leu Leu Lys Thr Gln Thr 
    450                 455                 460                 


Asp Phe Asn Asp Met Glu Asp Asp Asp Pro Gln Ile Ser Tyr Met Ile 
465                 470                 475                 480 


Ser Ala Trp Ala Arg Met Cys Lys Ile Leu Gly Lys Glu Phe Gln Gln 
                485                 490                 495     


Tyr Leu Pro Val Val Met Gly Pro Leu Met Lys Thr Ala Ser Ile Lys 
            500                 505                 510         


Pro Glu Val Ala Leu Leu Asp Thr Gln Asp Met Glu Asn Met Ser Asp 
        515                 520                 525             


Asp Asp Gly Trp Glu Phe Val Asn Leu Gly Asp Gln Gln Ser Phe Gly 
    530                 535                 540                 


Ile Lys Thr Ala Gly Leu Glu Glu Lys Ser Thr Ala Cys Gln Met Leu 
545                 550                 555                 560 


Val Cys Tyr Ala Lys Glu Leu Lys Glu Gly Phe Val Glu Tyr Thr Glu 
                565                 570                 575     


Gln Val Val Lys Leu Met Val Pro Leu Leu Lys Phe Tyr Phe His Asp 
            580                 585                 590         


Gly Val Arg Val Ala Ala Ala Glu Ser Met Pro Leu Leu Leu Glu Cys 
        595                 600                 605             


Ala Arg Val Arg Gly Pro Glu Tyr Leu Thr Gln Met Trp His Phe Met 
    610                 615                 620                 


Cys Asp Ala Leu Ile Lys Ala Ile Gly Thr Glu Pro Asp Ser Asp Val 
625                 630                 635                 640 


Leu Ser Glu Ile Met His Ser Phe Ala Lys Cys Ile Glu Val Met Gly 
                645                 650                 655     


Asp Gly Cys Leu Asn Asn Glu His Phe Glu Glu Leu Gly Gly Ile Leu 
            660                 665                 670         


Lys Ala Lys Leu Glu Glu His Phe Lys Asn Gln Glu Leu Arg Gln Val 
        675                 680                 685             


Lys Arg Gln Asp Glu Asp Tyr Asp Glu Gln Val Glu Glu Ser Leu Gln 
    690                 695                 700                 


Asp Glu Asp Asp Asn Asp Val Tyr Ile Leu Thr Lys Val Ser Asp Ile 
705                 710                 715                 720 


Leu His Ser Ile Phe Ser Ser Tyr Lys Glu Lys Val Leu Pro Trp Phe 
                725                 730                 735     


Glu Gln Leu Leu Pro Leu Ile Val Asn Leu Ile Cys Pro His Arg Pro 
            740                 745                 750         


Trp Pro Asp Arg Gln Trp Gly Leu Cys Ile Phe Asp Asp Val Ile Glu 
        755                 760                 765             


His Cys Ser Pro Ala Ser Phe Lys Tyr Ala Glu Tyr Phe Leu Arg Pro 
    770                 775                 780                 


Met Leu Gln Tyr Val Cys Asp Asn Ser Pro Glu Val Arg Gln Ala Ala 
785                 790                 795                 800 


Ala Tyr Gly Leu Gly Val Met Ala Gln Tyr Gly Gly Asp Asn Tyr Arg 
                805                 810                 815     


Pro Phe Cys Thr Glu Ala Leu Pro Leu Leu Val Arg Val Ile Gln Ser 
            820                 825                 830         


Ala Asp Ser Lys Thr Lys Glu Asn Val Asn Ala Thr Glu Asn Cys Ile 
        835                 840                 845             


Ser Ala Val Gly Lys Ile Met Lys Phe Lys Pro Asp Cys Val Asn Val 
    850                 855                 860                 


Glu Glu Val Leu Pro His Trp Leu Ser Trp Leu Pro Leu His Glu Asp 
865                 870                 875                 880 


Lys Glu Glu Ala Val Gln Thr Phe Asn Tyr Leu Cys Asp Leu Ile Glu 
                885                 890                 895     


Ser Asn His Pro Ile Val Leu Gly Pro Asn Asn Thr Asn Leu Pro Lys 
            900                 905                 910         


Ile Phe Ser Ile Ile Ala Glu Gly Glu Met His Glu Ala Ile Lys His 
        915                 920                 925             


Glu Asp Pro Cys Ala Lys Arg Leu Ala Asn Val Val Arg Gln Val Gln 
    930                 935                 940                 


Thr Ser Gly Gly Leu Trp Thr Glu Cys Ile Ala Gln Leu Ser Pro Glu 
945                 950                 955                 960 


Gln Gln Ala Ala Ile Gln Glu Leu Leu Asn Ser Ala 
                965                 970         


<210> 8813
<211> 475
<212> PRT
<213> Homo sapiens

<400> 8813
Met Gln Val Thr Phe Ile Tyr Val Cys Leu Lys Gly Leu Met Leu Gln 
1               5                   10                  15      


Asp Leu Val Ser Ala Lys Leu Ile Ser Asp Tyr Thr Val Thr Glu Ile 
            20                  25                  30          


Pro Asp Thr Ile Asn Asp Leu Gln Gly Ser Thr Lys Val Leu Gln Ala 
        35                  40                  45              


Val Gln Trp Leu Val Ser His Cys Pro His Ser Leu Asp Leu Cys Cys 
    50                  55                  60                  


Gln Thr Leu Ile Gln Tyr Val Glu Asp Gly Ile Gly His Glu Phe Ser 
65                  70                  75                  80  


Gly Arg Phe Phe His Asp Arg Arg Glu Arg Arg Leu Gly Gly Leu Ala 
                85                  90                  95      


Ser Gln Glu Pro Gly Ala Ile Ile Glu Leu Phe Asn Ser Val Leu Gln 
            100                 105                 110         


Phe Leu Ala Ser Val Val Ser Ser Glu Gln Leu Cys Asp Leu Ser Trp 
        115                 120                 125             


Pro Val Thr Glu Phe Ala Glu Ala Gly Gly Ser Arg Leu Leu Pro His 
    130                 135                 140                 


Leu His Trp Asn Ala Pro Glu His Leu Ala Trp Leu Lys Gln Ala Val 
145                 150                 155                 160 


Leu Gly Phe Gln Leu Pro Gln Met Asp Leu Pro Pro Leu Gly Ala Pro 
                165                 170                 175     


Trp Leu Pro Val Cys Ser Met Val Val Gln Tyr Ala Ser Gln Ile Pro 
            180                 185                 190         


Ser Ser Arg Gln Thr Gln Pro Val Leu Gln Ser Gln Val Glu Asn Leu 
        195                 200                 205             


Leu His Arg Thr Tyr Cys Arg Trp Lys Ser Lys Ser Pro Ser Pro Val 
    210                 215                 220                 


His Gly Ala Gly Pro Ser Val Met Glu Ile Pro Trp Asp Asp Leu Ile 
225                 230                 235                 240 


Ala Leu Cys Ile Asn His Lys Leu Arg Asp Trp Thr Pro Pro Arg Leu 
                245                 250                 255     


Pro Val Thr Ser Glu Ala Leu Ser Glu Asp Gly Gln Ile Cys Val Tyr 
            260                 265                 270         


Phe Phe Lys Asn Asp Leu Lys Lys Tyr Asp Val Pro Leu Ser Trp Glu 
        275                 280                 285             


Gln Ala Arg Leu Gln Thr Gln Lys Glu Leu Gln Leu Arg Glu Gly Arg 
    290                 295                 300                 


Leu Ala Ile Lys Pro Phe His Pro Ser Ala Asn Asn Phe Pro Ile Pro 
305                 310                 315                 320 


Leu Leu His Met His Arg Asn Trp Lys Arg Ser Thr Glu Cys Ala Gln 
                325                 330                 335     


Glu Gly Arg Ile Pro Ser Thr Glu Asp Leu Met Arg Gly Ala Ser Ala 
            340                 345                 350         


Glu Glu Leu Leu Ala Gln Cys Leu Ser Ser Ser Leu Leu Leu Glu Lys 
        355                 360                 365             


Glu Glu Asn Lys Arg Phe Glu Asp Gln Leu Gln Gln Trp Leu Ser Glu 
    370                 375                 380                 


Asp Ser Gly Ala Phe Thr Asp Leu Thr Ser Leu Pro Leu Tyr Leu Pro 
385                 390                 395                 400 


Gln Thr Leu Val Ser Leu Ser His Thr Ile Glu Pro Val Met Lys Thr 
                405                 410                 415     


Ser Val Thr Thr Ser Pro Gln Ser Asp Met Met Arg Glu Gln Leu Gln 
            420                 425                 430         


Leu Ser Glu Ala Thr Gly Thr Cys Leu Gly Glu Arg Leu Lys His Leu 
        435                 440                 445             


Glu Arg Leu Ile Arg Ser Ser Arg Glu Glu Glu Val Ala Ser Glu Leu 
    450                 455                 460                 


His Leu Ser Ala Leu Leu Asp Met Val Asp Ile 
465                 470                 475 


<210> 8814
<211> 110
<212> PRT
<213> Homo sapiens

<400> 8814
Met Ser Thr Ala Leu Thr His Thr Thr Val Ala Met Arg Cys Pro Met 
1               5                   10                  15      


Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro Gln Pro Trp Gly His 
            20                  25                  30          


Pro Asp Val His Ile Met Gln His His Val Leu Pro Ile Gln Ala Arg 
        35                  40                  45              


Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val Pro Pro Pro Val Met 
    50                  55                  60                  


Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp Asp Ser Val Asp Glu 
65                  70                  75                  80  


Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys Leu Asp Phe Arg Arg 
                85                  90                  95      


Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys Asp Glu Glu 
            100                 105                 110 


<210> 8815
<211> 275
<212> PRT
<213> Homo sapiens

<400> 8815
Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210> 8816
<211> 291
<212> PRT
<213> Homo sapiens

<400> 8816
Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu Ser Leu Phe Gly Asp Ser 
1               5                   10                  15      


Lys Lys Leu Thr Ala His Ser Asn Tyr Thr Gln Lys Thr Leu Lys Tyr 
            20                  25                  30          


Phe Ser Met Ile Leu Glu Glu Val Gly Gln Phe Thr Ser Ser Ser Leu 
        35                  40                  45              


Gly Asp Val Glu Ile Ala Glu Val Asn Val Lys Gly Leu Phe Val Lys 
    50                  55                  60                  


Leu Ile Asn Ser Ser Leu Asp Lys Glu Met Ala Ile Gly Asp His Ile 
65                  70                  75                  80  


Leu Gln Gln Asn Val Asn Gly Gln Thr Ile Ser Leu Tyr Arg Phe Leu 
                85                  90                  95      


Pro Asn Ile Val Met Gln Ala Asn Ser Thr Val Thr Val Trp Ala Ala 
            100                 105                 110         


Ala Ser Glu Ala Lys His Gln Pro Pro Ser Asp Phe Leu Trp Lys Glu 
        115                 120                 125             


Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu Cys Lys 
    130                 135                 140                 


Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys Gln 
145                 150                 155                 160 


Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser Val 
                165                 170                 175     


Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser Thr 
            180                 185                 190         


Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile Ser 
        195                 200                 205             


Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys Glu 
    210                 215                 220                 


Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn Pro 
225                 230                 235                 240 


Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn Thr 
                245                 250                 255     


Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser Thr 
            260                 265                 270         


Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu Ser 
        275                 280                 285             


Gln Lys Gln 
    290     


<210> 8817
<211> 394
<212> PRT
<213> Homo sapiens

<400> 8817
Met Val Pro Ser Gln Ala Pro Tyr Leu Val Pro Ala Phe Pro Leu Pro 
1               5                   10                  15      


Ala Ala Thr Ser Pro Gly Arg Glu Tyr Ala Ala Pro Gly Thr Ala Pro 
            20                  25                  30          


Glu Gly Leu His Gly Leu Pro Leu Ser Glu Gly Leu Gln Pro Tyr Pro 
        35                  40                  45              


Ala Phe Pro Phe Pro Tyr Leu Asp Thr Phe Met Thr Val Phe Leu Pro 
    50                  55                  60                  


Asp Pro Pro Val Cys Pro Leu Leu Ser Pro Ser Phe Leu Pro Cys Pro 
65                  70                  75                  80  


Phe Leu Gly Ala Thr Ala Ser Ser Ala Ile Ser Pro Ser Met Ser Ser 
                85                  90                  95      


Ala Met Ser Pro Thr Leu Asp Pro Pro Pro Ser Val Thr Ser Gln Arg 
            100                 105                 110         


Arg Glu Glu Glu Lys Trp Glu Ala Gln Ser Glu Gly His Pro Phe Ile 
        115                 120                 125             


Thr Ser Arg Ser Ser Ser Pro Leu Gln Leu Asn Leu Leu Gln Glu Glu 
    130                 135                 140                 


Met Pro Arg Pro Ser Glu Ser Pro Asp Gln Met Arg Arg Asn Thr Cys 
145                 150                 155                 160 


Pro Gln Thr Glu Tyr Cys Val Thr Gly Asn Asn Gly Ser Glu Ser Ser 
                165                 170                 175     


Pro Ala Thr Thr Gly Ala Leu Ser Thr Gly Ser Pro Pro Arg Glu Asn 
            180                 185                 190         


Pro Ser His Pro Thr Ala Ser Ala Leu Ser Thr Gly Ser Pro Pro Met 
        195                 200                 205             


Lys Asn Pro Ser His Pro Thr Ala Ser Thr Leu Ser Met Gly Leu Pro 
    210                 215                 220                 


Pro Ser Arg Thr Pro Ser His Pro Thr Ala Thr Val Leu Ser Thr Gly 
225                 230                 235                 240 


Ser Pro Pro Ser Glu Ser Pro Ser Arg Thr Gly Ser Ala Ala Ser Gly 
                245                 250                 255     


Ser Ser Asp Ser Ser Ile Tyr Leu Thr Ser Ser Val Tyr Ser Ser Lys 
            260                 265                 270         


Ile Ser Gln Asn Gly Gln Gln Ser Gln Asp Val Gln Lys Lys Glu Thr 
        275                 280                 285             


Phe Pro Asn Val Ala Glu Glu Pro Ile Trp Arg Met Ile Arg Gln Thr 
    290                 295                 300                 


Pro Glu Arg Ile Leu Met Thr Tyr Gln Val Pro Glu Arg Val Lys Glu 
305                 310                 315                 320 


Val Val Leu Lys Glu Asp Leu Glu Lys Leu Glu Ser Met Arg Gln Gln 
                325                 330                 335     


Gln Pro Gln Phe Ser His Gly Gln Lys Glu Glu Leu Ala Lys Val Tyr 
            340                 345                 350         


Asn Trp Ile Gln Ser Gln Thr Val Thr Gln Glu Ile Asp Ile Gln Ala 
        355                 360                 365             


Cys Val Thr Cys Glu Asn Glu Asp Ser Ala Asp Gly Ala Ala Thr Ser 
    370                 375                 380                 


Cys Gly Gln Val Leu Val Glu Asp Ser Cys 
385                 390                 


<210> 8818
<211> 807
<212> PRT
<213> Homo sapiens

<400> 8818
Gln Gly Ala Ser Phe Ala Leu Ala Ala Ala Ala Ala Leu Leu Phe Gly 
1               5                   10                  15      


Ser Asp Met Glu Asp Gly Pro Ser Asn Asn Ala Ser Cys Phe Arg Arg 
            20                  25                  30          


Leu Thr Glu Cys Phe Leu Ser Pro Ser Leu Thr Asp Glu Lys Val Lys 
        35                  40                  45              


Ala Tyr Leu Ser Leu His Pro Gln Val Leu Asp Glu Phe Val Ser Glu 
    50                  55                  60                  


Ser Val Ser Ala Glu Thr Val Glu Lys Trp Leu Lys Arg Lys Asn Asn 
65                  70                  75                  80  


Lys Ser Glu Asp Glu Ser Ala Pro Lys Glu Val Ser Arg Tyr Gln Asp 
                85                  90                  95      


Thr Asn Met Gln Gly Val Val Tyr Glu Leu Asn Ser Tyr Ile Glu Gln 
            100                 105                 110         


Arg Leu Asp Thr Gly Gly Asp Asn Gln Leu Leu Leu Tyr Glu Leu Ser 
        115                 120                 125             


Ser Ile Ile Lys Ile Ala Thr Lys Ala Asp Gly Phe Ala Leu Tyr Phe 
    130                 135                 140                 


Leu Gly Glu Cys Asn Asn Ser Leu Cys Ile Phe Thr Pro Pro Gly Ile 
145                 150                 155                 160 


Lys Glu Gly Lys Pro Arg Leu Ile Pro Ala Gly Pro Ile Thr Gln Gly 
                165                 170                 175     


Thr Thr Val Ser Ala Tyr Val Ala Lys Ser Arg Lys Thr Leu Leu Val 
            180                 185                 190         


Glu Asp Ile Leu Gly Asp Glu Arg Phe Pro Arg Gly Thr Gly Leu Glu 
        195                 200                 205             


Ser Gly Thr Arg Ile Gln Ser Val Leu Cys Leu Pro Ile Val Thr Ala 
    210                 215                 220                 


Ile Gly Asp Leu Ile Gly Ile Leu Glu Leu Tyr Arg His Trp Gly Lys 
225                 230                 235                 240 


Glu Ala Phe Cys Leu Ser His Gln Glu Val Ala Thr Ala Asn Leu Ala 
                245                 250                 255     


Trp Ala Ser Val Ala Ile His Gln Val Gln Val Cys Arg Gly Leu Ala 
            260                 265                 270         


Lys Gln Thr Glu Leu Asn Asp Phe Leu Leu Asp Val Ser Lys Thr Tyr 
        275                 280                 285             


Phe Asp Asn Ile Val Ala Ile Asp Ser Leu Leu Glu His Ile Met Ile 
    290                 295                 300                 


Tyr Ala Lys Asn Leu Val Asn Ala Asp Arg Cys Ala Leu Phe Gln Val 
305                 310                 315                 320 


Asp His Lys Asn Lys Glu Leu Tyr Ser Asp Leu Phe Asp Ile Gly Glu 
                325                 330                 335     


Glu Lys Glu Gly Lys Pro Val Phe Lys Lys Thr Lys Glu Ile Arg Phe 
            340                 345                 350         


Ser Ile Glu Lys Gly Ile Ala Gly Gln Val Ala Arg Thr Gly Glu Val 
        355                 360                 365             


Leu Asn Ile Pro Asp Ala Tyr Ala Asp Pro Arg Phe Asn Arg Glu Val 
    370                 375                 380                 


Asp Leu Tyr Thr Gly Tyr Thr Thr Arg Asn Ile Leu Cys Met Pro Ile 
385                 390                 395                 400 


Val Ser Arg Gly Ser Val Ile Gly Val Val Gln Met Val Asn Lys Ile 
                405                 410                 415     


Ser Gly Ser Ala Phe Ser Lys Thr Asp Glu Asn Asn Phe Lys Met Phe 
            420                 425                 430         


Ala Val Phe Cys Ala Leu Ala Leu His Cys Ala Asn Met Tyr His Arg 
        435                 440                 445             


Ile Arg His Ser Glu Cys Ile Tyr Arg Val Thr Met Glu Lys Leu Ser 
    450                 455                 460                 


Tyr His Ser Ile Cys Thr Ser Glu Glu Trp Gln Gly Leu Met Gln Phe 
465                 470                 475                 480 


Thr Leu Pro Val Arg Leu Cys Lys Glu Ile Glu Leu Phe His Phe Asp 
                485                 490                 495     


Ile Gly Pro Phe Glu Asn Met Trp Pro Gly Ile Phe Val Tyr Met Val 
            500                 505                 510         


His Arg Ser Cys Gly Thr Ser Cys Phe Glu Leu Glu Lys Leu Cys Arg 
        515                 520                 525             


Phe Ile Met Ser Val Lys Lys Asn Tyr Arg Arg Val Pro Tyr His Asn 
    530                 535                 540                 


Trp Lys His Ala Val Thr Val Ala His Cys Met Tyr Ala Ile Leu Gln 
545                 550                 555                 560 


Asn Asn His Thr Leu Phe Thr Asp Leu Glu Arg Lys Gly Leu Leu Ile 
                565                 570                 575     


Ala Cys Leu Cys His Asp Leu Asp His Arg Gly Phe Ser Asn Ser Tyr 
            580                 585                 590         


Leu Gln Lys Phe Asp His Pro Leu Ala Ala Leu Tyr Ser Thr Ser Thr 
        595                 600                 605             


Met Glu Gln His His Phe Ser Gln Thr Val Ser Ile Leu Gln Leu Glu 
    610                 615                 620                 


Gly His Asn Ile Phe Ser Thr Leu Ser Ser Ser Glu Tyr Glu Gln Val 
625                 630                 635                 640 


Leu Glu Ile Ile Arg Lys Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
                645                 650                 655     


Phe Gly Asn Arg Lys Gln Leu Glu Glu Met Tyr Gln Thr Gly Ser Leu 
            660                 665                 670         


Asn Leu Asn Asn Gln Ser His Arg Asp Arg Val Ile Gly Leu Met Met 
        675                 680                 685             


Thr Ala Cys Asp Leu Cys Ser Val Thr Lys Leu Trp Pro Val Thr Lys 
    690                 695                 700                 


Leu Thr Ala Asn Asp Ile Tyr Ala Glu Phe Trp Ala Glu Gly Asp Glu 
705                 710                 715                 720 


Met Lys Lys Leu Gly Ile Gln Pro Ile Pro Met Met Asp Arg Asp Lys 
                725                 730                 735     


Lys Asp Glu Val Pro Gln Gly Gln Leu Gly Phe Tyr Asn Ala Val Ala 
            740                 745                 750         


Ile Pro Cys Tyr Thr Thr Leu Thr Gln Ile Leu Pro Pro Thr Glu Pro 
        755                 760                 765             


Leu Leu Lys Ala Cys Arg Asp Asn Leu Ser Gln Trp Glu Lys Val Ile 
    770                 775                 780                 


Arg Gly Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro Ser Val Ala Gln 
785                 790                 795                 800 


Lys Ala Ala Ala Ser Glu Asp 
                805         


<210> 8819
<211> 558
<212> PRT
<213> Homo sapiens

<400> 8819
Met Ala Ser Cys Pro Asp Ser Asp Asn Ser Trp Val Leu Ala Gly Gly 
1               5                   10                  15      


Glu Leu Gly Ile Ser Leu Asn Met Cys Leu Leu Gly Ala Leu Val Leu 
            20                  25                  30          


Leu Gly Leu Gly Val Leu Leu Phe Ser Gly Gly Leu Ser Glu Ser Glu 
        35                  40                  45              


Thr Gly Pro Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu 
    50                  55                  60                  


Val Leu Glu Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu 
65                  70                  75                  80  


Gln Ala Pro Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly 
                85                  90                  95      


Leu Leu Leu Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu 
            100                 105                 110         


Gln Ala Gln Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu Met His 
        115                 120                 125             


Gln Pro Lys Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly Ala Leu 
    130                 135                 140                 


Gln Gln Gly Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu Gln Gln 
145                 150                 155                 160 


Leu Arg Ala Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg Gly Pro 
                165                 170                 175     


Asp Gly Val Cys Leu Ser Gly Gly Arg Gly Pro Gln Gly Asp Lys Ala 
            180                 185                 190         


Ile Arg Glu Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser Phe Leu 
        195                 200                 205             


Lys Gln Lys Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg Gln Glu 
    210                 215                 220                 


Leu Glu Arg Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp Leu Glu 
225                 230                 235                 240 


Arg Ser Leu Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala Gly Leu 
                245                 250                 255     


Ala Glu Leu Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu Glu Asn 
            260                 265                 270         


Trp Gly Gln Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala Trp His 
        275                 280                 285             


Gln Lys Ser His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys Glu Lys 
    290                 295                 300                 


Trp Trp Asp Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys His Lys 
305                 310                 315                 320 


Lys Glu Glu Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly Gln Glu 
                325                 330                 335     


Asp Arg Glu Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg Val Glu 
            340                 345                 350         


Glu Ser Gly Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys Glu Pro 
        355                 360                 365             


Pro Arg Lys Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln Lys Gln 
    370                 375                 380                 


Pro Arg Trp Arg Glu Gly Thr Lys Asp Ser His Asp Pro Leu Pro Ser 
385                 390                 395                 400 


Trp Ala Glu Leu Leu Arg Pro Lys Tyr Arg Ala Pro Gln Gly Cys Ser 
                405                 410                 415     


Gly Val Asp Glu Cys Ala Arg Gln Glu Gly Leu Thr Phe Phe Gly Thr 
            420                 425                 430         


Glu Leu Ala Pro Val Arg Gln Gln Glu Leu Ala Ser Leu Leu Arg Thr 
        435                 440                 445             


Tyr Leu Ala Arg Leu Pro Trp Ala Gly Gln Leu Thr Lys Glu Leu Pro 
    450                 455                 460                 


Leu Ser Pro Ala Phe Phe Gly Glu Asp Gly Ile Phe Arg His Asp Arg 
465                 470                 475                 480 


Leu Arg Phe Arg Asp Phe Val Asp Ala Leu Glu Asp Ser Leu Glu Glu 
                485                 490                 495     


Val Ala Val Gln Gln Thr Gly Asp Asp Asp Glu Val Asp Asp Phe Glu 
            500                 505                 510         


Asp Phe Ile Phe Ser His Phe Phe Gly Asp Lys Ala Leu Lys Lys Arg 
        515                 520                 525             


Ser Gly Lys Lys Asp Lys His Ser Gln Ser Pro Arg Ala Ala Gly Pro 
    530                 535                 540                 


Arg Glu Gly His Ser His Ser His His His His His Arg Gly 
545                 550                 555             


<210> 8820
<211> 626
<212> PRT
<213> Homo sapiens

<400> 8820
Met Gly Asn Ala Ala Gly Ser Ala Glu Gln Pro Ala Gly Pro Ala Ala 
1               5                   10                  15      


Pro Pro Pro Lys Gln His Arg Phe Glu Lys Leu Met Glu Tyr Phe Arg 
            20                  25                  30          


Asn Glu Asp Ser Asn Ile Asp Phe Met Val Ala Cys Met Gln Phe Ile 
        35                  40                  45              


Asn Ile Val Val His Ser Val Glu Asn Met Asn Phe Arg Val Phe Leu 
    50                  55                  60                  


Gln Tyr Glu Phe Thr His Leu Gly Leu Asp Leu Tyr Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Leu Thr Glu Ser Asp Lys Leu Gln Val Gln Ile Gln Ala Tyr Leu 
                85                  90                  95      


Asp Asn Ile Phe Asp Val Gly Ala Leu Leu Glu Asp Thr Glu Thr Lys 
            100                 105                 110         


Asn Ala Val Leu Glu His Met Glu Glu Leu Gln Glu Gln Val Ala Leu 
        115                 120                 125             


Leu Thr Glu Arg Leu Arg Asp Ala Glu Asn Glu Ser Met Ala Lys Ile 
    130                 135                 140                 


Ala Glu Leu Glu Lys Gln Leu Ser Gln Ala Arg Lys Glu Leu Glu Thr 
145                 150                 155                 160 


Leu Arg Glu Arg Phe Ser Glu Ser Thr Ala Met Gly Pro Ser Arg Arg 
                165                 170                 175     


Pro Pro Glu Pro Glu Lys Ala Pro Pro Ala Ala Pro Thr Arg Pro Ser 
            180                 185                 190         


Ala Leu Glu Leu Lys Val Glu Glu Leu Glu Glu Lys Gly Leu Ile Arg 
        195                 200                 205             


Ile Leu Arg Gly Pro Gly Asp Ala Val Ser Ile Glu Ile Leu Pro Val 
    210                 215                 220                 


Ala Val Ala Thr Pro Ser Gly Gly Asp Ala Pro Thr Pro Gly Val Pro 
225                 230                 235                 240 


Thr Gly Ser Pro Ser Pro Asp Leu Ala Pro Ala Ala Glu Pro Ala Pro 
                245                 250                 255     


Gly Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro Gly Gly Pro Pro Asp 
            260                 265                 270         


Ala Leu Gly Arg Arg Asp Ser Glu Leu Gly Pro Gly Val Lys Ala Lys 
        275                 280                 285             


Lys Pro Ile Gln Thr Lys Phe Arg Met Pro Leu Leu Asn Trp Val Ala 
    290                 295                 300                 


Leu Lys Pro Ser Gln Ile Thr Gly Thr Val Phe Thr Glu Leu Asn Asp 
305                 310                 315                 320 


Glu Lys Val Leu Gln Glu Leu Asp Met Ser Asp Phe Glu Glu Gln Phe 
                325                 330                 335     


Lys Thr Lys Ser Gln Gly Pro Ser Leu Asp Leu Ser Ala Leu Lys Ser 
            340                 345                 350         


Lys Ala Ala Gln Lys Ala Pro Ser Lys Ala Thr Leu Ile Glu Ala Asn 
        355                 360                 365             


Arg Ala Lys Asn Leu Ala Ile Thr Leu Arg Lys Gly Asn Leu Gly Ala 
    370                 375                 380                 


Glu Arg Ile Cys Gln Ala Ile Glu Ala Tyr Asp Leu Gln Ala Leu Gly 
385                 390                 395                 400 


Leu Asp Phe Leu Glu Leu Leu Met Arg Phe Leu Pro Thr Glu Tyr Glu 
                405                 410                 415     


Arg Ser Leu Ile Thr Arg Phe Glu Arg Glu Gln Arg Pro Met Glu Glu 
            420                 425                 430         


Leu Ser Glu Glu Asp Arg Phe Met Leu Cys Phe Ser Arg Ile Pro Arg 
        435                 440                 445             


Leu Pro Glu Arg Met Thr Thr Leu Thr Phe Leu Gly Asn Phe Pro Asp 
    450                 455                 460                 


Thr Ala Gln Leu Leu Met Pro Gln Leu Asn Ala Ile Ile Ala Ala Ser 
465                 470                 475                 480 


Met Ser Ile Lys Ser Ser Asp Lys Leu Arg Gln Ile Leu Glu Ile Val 
                485                 490                 495     


Leu Ala Phe Gly Asn Tyr Met Asn Ser Ser Lys Arg Gly Ala Ala Tyr 
            500                 505                 510         


Gly Phe Arg Leu Gln Ser Leu Asp Ala Leu Leu Glu Met Lys Ser Thr 
        515                 520                 525             


Asp Arg Lys Gln Thr Leu Leu His Tyr Leu Val Lys Val Ile Ala Glu 
    530                 535                 540                 


Lys Tyr Pro Gln Leu Thr Gly Phe His Ser Asp Leu His Phe Leu Asp 
545                 550                 555                 560 


Lys Ala Gly Ser Val Ser Leu Asp Ser Val Leu Ala Asp Val Arg Ser 
                565                 570                 575     


Leu Gln Arg Gly Leu Glu Leu Thr Gln Arg Glu Phe Val Arg Gln Asp 
            580                 585                 590         


Asp Cys Met Val Leu Lys Glu Phe Leu Arg Ala Asn Ser Pro Thr Met 
        595                 600                 605             


Asp Lys Leu Leu Ala Asp Ser Lys Thr Ala Gln Ala Val Pro Thr Gly 
    610                 615                 620                 


Gly Leu 
625     


<210> 8821
<211> 499
<212> PRT
<213> Homo sapiens

<400> 8821
Met Asp Lys Leu Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn 
1               5                   10                  15      


Asp Gly Ala Thr Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala 
            20                  25                  30          


Lys Thr Leu Val Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp 
        35                  40                  45              


Gly Thr Thr Ser Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val 
    50                  55                  60                  


Lys Pro Tyr Val Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala 
65                  70                  75                  80  


Phe Arg Thr Ala Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala 
                85                  90                  95      


Val Thr Val Lys Lys Ala Asp Lys Val Glu Gln Arg Lys Leu Leu Glu 
            100                 105                 110         


Lys Cys Ala Met Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys 
        115                 120                 125             


Ala Phe Phe Ala Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp 
    130                 135                 140                 


Leu Leu Gln Leu Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala 
145                 150                 155                 160 


Leu Glu Asp Ser Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe 
                165                 170                 175     


Ser Tyr Ala Gly Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys 
            180                 185                 190         


Ile Ala Leu Leu Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn 
        195                 200                 205             


Ala Glu Ile Arg Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp 
    210                 215                 220                 


Ala Glu Trp Asn Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser 
225                 230                 235                 240 


Gly Ala Lys Val Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr 
                245                 250                 255     


Gln Tyr Phe Ala Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu 
            260                 265                 270         


Glu Asp Leu Lys Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr 
        275                 280                 285             


Ser Val Asn Ala Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe 
    290                 295                 300                 


Glu Glu Thr Gln Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys 
305                 310                 315                 320 


Pro Lys Ala Lys Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln 
                325                 330                 335     


Phe Met Glu Glu Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val 
            340                 345                 350         


Arg Arg Ala Ile Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile 
        355                 360                 365             


Glu Met Glu Leu Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro 
    370                 375                 380                 


Gly Lys Gln Gln Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile 
385                 390                 395                 400 


Ile Pro Arg Gln Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile 
                405                 410                 415     


Leu Asn Lys Leu Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly 
            420                 425                 430         


Val Asp Ile Asn Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val 
        435                 440                 445             


Trp Glu Pro Ala Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu 
    450                 455                 460                 


Ala Ala Cys Leu Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg 
465                 470                 475                 480 


Ser Thr Val Asp Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly 
                485                 490                 495     


Arg Pro His 
            


<210> 8822
<211> 25
<212> PRT
<213> Homo sapiens

<400> 8822
Met Ala His Glu Met Ile Gly Thr Gln Ile Val Thr Glu Arg Leu Val 
1               5                   10                  15      


Ala Leu Leu Glu Ser Gly Thr Glu Lys 
            20                  25  


<210> 8823
<211> 210
<212> PRT
<213> Homo sapiens

<400> 8823
Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Val Ala Tyr Lys Asn Val 
1               5                   10                  15      


Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser Ile Glu Gln 
            20                  25                  30          


Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys Asp Tyr Arg 
        35                  40                  45              


Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr Val Leu Glu 
    50                  55                  60                  


Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr Leu Ala Glu 
                85                  90                  95      


Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Asp Asn Ser Gln Gly 
            100                 105                 110         


Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met Gln Pro Thr 
        115                 120                 125             


His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val Phe Tyr Tyr 
    130                 135                 140                 


Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala Lys Thr Ala 
145                 150                 155                 160 


Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu Asp Ser Tyr 
                165                 170                 175     


Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn Leu Thr Leu 
            180                 185                 190         


Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala Glu Gly Ala 
        195                 200                 205             


Glu Asn 
    210 


<210> 8824
<211> 166
<212> PRT
<213> Homo sapiens

<400> 8824
Met Asp Leu Met Pro Phe Ile Asn Lys Ala Gly Cys Glu Cys Leu Asn 
1               5                   10                  15      


Glu Ser Asp Glu His Gly Phe Asp Asn Cys Leu Arg Lys Asp Thr Thr 
            20                  25                  30          


Phe Leu Glu Ser Asp Cys Asp Glu Gln Leu Leu Ile Thr Val Ala Phe 
        35                  40                  45              


Asn Gln Pro Val Lys Leu Tyr Ser Met Lys Phe Gln Gly Pro Asp Asn 
    50                  55                  60                  


Gly Gln Gly Pro Lys Tyr Val Lys Ile Phe Ile Asn Leu Pro Arg Ser 
65                  70                  75                  80  


Met Asp Phe Glu Glu Ala Glu Arg Ser Glu Pro Thr Gln Ala Leu Glu 
                85                  90                  95      


Leu Thr Glu Asp Asp Ile Lys Glu Asp Gly Ile Val Pro Leu Arg Tyr 
            100                 105                 110         


Val Lys Phe Gln Asn Val Asn Ser Val Thr Ile Phe Val Gln Ser Asn 
        115                 120                 125             


Gln Gly Glu Glu Glu Thr Thr Arg Ile Ser Tyr Phe Thr Phe Ile Gly 
    130                 135                 140                 


Thr Pro Val Gln Ala Thr Asn Met Asn Asp Phe Lys Arg Val Val Gly 
145                 150                 155                 160 


Lys Lys Gly Glu Ser His 
                165     


<210> 8825
<211> 212
<212> PRT
<213> Homo sapiens

<400> 8825
Met Ala Ala Pro Glu Glu Arg Asp Leu Thr Gln Glu Gln Thr Glu Lys 
1               5                   10                  15      


Leu Leu Gln Phe Gln Asp Leu Thr Gly Ile Glu Ser Met Asp Gln Cys 
            20                  25                  30          


Arg His Thr Leu Glu Gln His Asn Trp Asn Ile Glu Ala Ala Val Gln 
        35                  40                  45              


Asp Arg Leu Asn Glu Gln Glu Gly Val Pro Ser Val Phe Asn Pro Pro 
    50                  55                  60                  


Pro Ser Arg Pro Leu Gln Val Asn Thr Ala Asp His Arg Ile Tyr Ser 
65                  70                  75                  80  


Tyr Val Val Ser Arg Pro Gln Pro Arg Gly Leu Leu Gly Trp Gly Tyr 
                85                  90                  95      


Tyr Leu Ile Met Leu Pro Phe Arg Phe Thr Tyr Tyr Thr Ile Leu Asp 
            100                 105                 110         


Ile Phe Arg Phe Ala Leu Arg Phe Ile Arg Pro Asp Pro Arg Ser Arg 
        115                 120                 125             


Val Thr Asp Pro Val Gly Asp Ile Val Ser Phe Met His Ser Phe Glu 
    130                 135                 140                 


Glu Lys Tyr Gly Arg Ala His Pro Val Phe Tyr Gln Gly Thr Tyr Ser 
145                 150                 155                 160 


Gln Ala Leu Asn Asp Ala Lys Arg Glu Leu Arg Phe Leu Leu Val Tyr 
                165                 170                 175     


Leu His Gly Asp Asp His Gln Asp Ser Asp Glu Phe Cys Arg Asn Thr 
            180                 185                 190         


Leu Cys Ala Pro Glu Val Ile Ser Leu Ile Asn Thr Ser Ser His Ser 
        195                 200                 205             


Phe Leu Leu Leu 
    210         


<210> 8826
<211> 456
<212> PRT
<213> Homo sapiens

<400> 8826
Met Ala Asp Ser Leu Glu Ser Thr Pro Leu Pro Ser Pro Glu Asp Arg 
1               5                   10                  15      


Leu Ala Lys Leu His Pro Ser Lys Glu Leu Leu Glu Tyr Tyr Gln Lys 
            20                  25                  30          


Lys Met Ala Glu Cys Glu Ala Glu Asn Glu Asp Leu Leu Lys Lys Leu 
        35                  40                  45              


Glu Leu Tyr Lys Glu Ala Cys Glu Gly Gln His Lys Leu Glu Cys Asp 
    50                  55                  60                  


Leu Gln Gln Arg Glu Glu Glu Ile Ala Glu Leu Gln Lys Ala Leu Ser 
65                  70                  75                  80  


Asp Met Gln Val Cys Leu Phe Gln Glu Arg Glu His Val Leu Arg Leu 
                85                  90                  95      


Tyr Ser Glu Asn Asp Arg Leu Arg Ile Arg Glu Leu Glu Asp Lys Lys 
            100                 105                 110         


Lys Ile Gln Asn Leu Leu Ala Leu Val Gly Thr Asp Ala Gly Glu Val 
        115                 120                 125             


Thr Tyr Phe Cys Lys Glu Pro Pro His Lys Val Thr Ile Leu Gln Lys 
    130                 135                 140                 


Thr Ile Gln Ala Val Gly Glu Cys Glu Gln Ser Glu Ser Ser Ala Phe 
145                 150                 155                 160 


Lys Ala Asp Pro Lys Ile Ser Lys Arg Arg Pro Ser Arg Glu Arg Lys 
                165                 170                 175     


Glu Ser Ser Glu His Tyr Gln Arg Asp Ile Gln Thr Leu Ile Leu Gln 
            180                 185                 190         


Val Glu Ala Leu Gln Ala Gln Leu Gly Glu Gln Thr Lys Leu Ser Arg 
        195                 200                 205             


Glu Gln Ile Glu Gly Leu Ile Glu Asp Arg Arg Ile His Leu Glu Glu 
    210                 215                 220                 


Ile Gln Val Gln His Gln Arg Asn Gln Asn Lys Ile Lys Glu Leu Thr 
225                 230                 235                 240 


Lys Asn Leu His His Thr Gln Glu Leu Leu Tyr Glu Ser Thr Lys Asp 
                245                 250                 255     


Phe Leu Gln Leu Arg Ser Glu Asn Gln Asn Lys Glu Lys Ser Trp Met 
            260                 265                 270         


Leu Glu Lys Asp Asn Leu Met Ser Lys Ile Lys Gln Tyr Arg Val Gln 
        275                 280                 285             


Cys Lys Lys Lys Glu Asp Lys Ile Gly Lys Val Leu Pro Val Met His 
    290                 295                 300                 


Glu Ser His His Ala Gln Ser Glu Tyr Ile Lys Ser Leu Lys Asp Lys 
305                 310                 315                 320 


Leu Val Gln Glu Lys Lys Leu Ser Asn Met Tyr Gln Glu Gln Cys Ile 
                325                 330                 335     


Ser Leu Glu Glu Glu Leu Ala Arg Ile Arg Glu Glu Glu Gly Met Arg 
            340                 345                 350         


Arg Glu Ile Phe Lys Asp Arg Thr Asn Lys Met Gly Lys Arg Leu Gln 
        355                 360                 365             


Ile Met Thr Lys Arg Tyr Glu Ala Leu Glu Arg Arg Arg Ile Leu Glu 
    370                 375                 380                 


Val Glu Gly Phe Lys Thr Asp Ile Lys Val Leu Arg Gln Lys Leu Lys 
385                 390                 395                 400 


Asp Leu Glu Gln Met Leu Tyr Lys Ala Thr Val Asn Ala Arg Ala Asn 
                405                 410                 415     


Gln Asp Leu Ala Leu Leu Cys Glu Val Arg Asp Ser Asn Arg Arg Ala 
            420                 425                 430         


His Lys Ile Gln Gly Glu Leu Lys Asn Leu Lys Ser Lys Val Phe Gly 
        435                 440                 445             


Leu Glu Asn Glu Leu Arg Leu Cys 
    450                 455     


<210> 8827
<211> 60
<212> PRT
<213> Homo sapiens

<400> 8827
Met Asp Glu Gln Ala Leu Leu Gly Leu Asn Pro Asn Ala Asp Ser Asp 
1               5                   10                  15      


Phe Arg Gln Arg Ala Leu Ala Tyr Phe Glu Gln Leu Lys Ile Ser Pro 
            20                  25                  30          


Asp Ala Trp Gln Val Cys Ala Glu Ala Leu Ala Gln Arg Thr Tyr Ser 
        35                  40                  45              


Asp Asp His Val Lys Phe Phe Cys Phe Gln Val Leu 
    50                  55                  60  


<210> 8828
<211> 112
<212> PRT
<213> Homo sapiens

<400> 8828
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Thr Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Thr His Gly Thr Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Thr Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


<210> 8829
<211> 390
<212> PRT
<213> Homo sapiens

<400> 8829
Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe 
            340                 345                 350         


His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln 
        355                 360                 365             


Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys 
    370                 375                 380                 


Leu Ile Gln Arg Arg Asp 
385                 390 


<210> 8830
<211> 444
<212> PRT
<213> Homo sapiens

<400> 8830
Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Asn Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Phe Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ser Val Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 


<210> 8831
<211> 164
<212> PRT
<213> Homo sapiens

<400> 8831
Met Val Asn Ser Val Val Phe Phe Asp Ile Thr Val Asp Gly Lys Pro 
1               5                   10                  15      


Leu Gly Arg Ile Ser Ile Lys Leu Phe Ala Asp Lys Ile Leu Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Arg Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Asp Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Asp Asp Glu Asn Leu Ile Arg Lys His Thr Gly Ser Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Ala Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Ala 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Arg Val Asn Ile Val Glu Ala Met Glu His 
    130                 135                 140                 


Phe Gly Tyr Arg Asn Ser Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Phe 
                


<210> 8832
<211> 1083
<212> PRT
<213> Homo sapiens

<400> 8832
Met Ser Gln Thr Gln Asp Tyr Glu Cys Arg Ser His Asn Val Asp Leu 
1               5                   10                  15      


Pro Glu Ser Arg Ile Pro Gly Ser Asn Thr Arg Leu Glu Trp Val Glu 
            20                  25                  30          


Ile Ile Glu Pro Arg Thr Arg Glu Arg Met Tyr Ala Asn Leu Val Thr 
        35                  40                  45              


Gly Glu Cys Val Trp Asp Pro Pro Ala Gly Val Arg Ile Lys Arg Thr 
    50                  55                  60                  


Ser Glu Asn Gln Trp Trp Glu Leu Phe Asp Pro Asn Thr Ser Arg Phe 
65                  70                  75                  80  


Tyr Tyr Tyr Asn Ala Ser Thr Gln Arg Thr Val Trp His Arg Pro Gln 
                85                  90                  95      


Gly Cys Asp Ile Ile Pro Leu Ala Lys Leu Gln Thr Leu Lys Gln Asn 
            100                 105                 110         


Thr Glu Ser Pro Arg Ala Ser Ala Glu Ser Ser Pro Gly Arg Gly Ser 
        115                 120                 125             


Ser Val Ser Arg Glu Gly Ser Thr Ser Ser Ser Leu Glu Pro Glu Pro 
    130                 135                 140                 


Asp Thr Glu Lys Ala Gln Glu Leu Pro Ala Arg Ala Gly Arg Pro Ala 
145                 150                 155                 160 


Ala Phe Gly Thr Val Lys Glu Asp Ser Gly Ser Ser Ser Pro Pro Gly 
                165                 170                 175     


Val Phe Leu Glu Lys Asp Tyr Glu Ile Tyr Arg Asp Tyr Ser Ala Asp 
            180                 185                 190         


Gly Gln Leu Leu His Tyr Arg Thr Ser Ser Leu Arg Trp Asn Ser Gly 
        195                 200                 205             


Ala Lys Glu Arg Met Leu Ile Lys Val Ala Asp Arg Glu Pro Ser Phe 
    210                 215                 220                 


Leu Ala Ala Gln Gly Asn Gly Tyr Ala Pro Asp Gly Pro Pro Gly Val 
225                 230                 235                 240 


Arg Ser Arg Arg Pro Ser Gly Ser Gln His Ser Pro Ser Leu Gln Thr 
                245                 250                 255     


Phe Ala Pro Glu Ala Asp Gly Thr Ile Phe Phe Pro Glu Arg Arg Pro 
            260                 265                 270         


Ser Pro Phe Leu Lys Arg Ala Glu Leu Pro Gly Ser Ser Ser Pro Leu 
        275                 280                 285             


Leu Ala Gln Pro Arg Lys Pro Ser Gly Asp Ser Gln Pro Ser Ser Pro 
    290                 295                 300                 


Arg Tyr Gly Tyr Glu Pro Pro Leu Tyr Glu Glu Pro Pro Val Glu Tyr 
305                 310                 315                 320 


Gln Ala Pro Ile Tyr Asp Glu Pro Pro Met Asp Val Gln Phe Glu Ala 
                325                 330                 335     


Gly Gly Gly Tyr Gln Ala Gly Ser Pro Gln Arg Ser Pro Gly Arg Lys 
            340                 345                 350         


Pro Arg Pro Phe Leu Gln Pro Asn Lys Gln Gly Pro Pro Ser Pro Cys 
        355                 360                 365             


Gln Gln Leu Val Leu Thr Lys Gln Lys Cys Pro Glu Arg Phe Leu Ser 
    370                 375                 380                 


Leu Glu Tyr Ser Pro Ala Gly Lys Glu Tyr Val Arg Gln Leu Val Tyr 
385                 390                 395                 400 


Val Glu Gln Ala Gly Ser Ser Pro Lys Leu Arg Ala Gly Pro Arg His 
                405                 410                 415     


Lys Tyr Ala Pro Asn Pro Gly Gly Gly Ser Tyr Ser Leu Gln Pro Ser 
            420                 425                 430         


Pro Cys Leu Leu Arg Asp Gln Arg Leu Gly Val Lys Ser Gly Asp Tyr 
        435                 440                 445             


Ser Thr Met Glu Gly Pro Glu Leu Arg His Ser Gln Pro Pro Thr Pro 
    450                 455                 460                 


Leu Pro Gln Ala Gln Glu Asp Ala Met Ser Trp Ser Ser Gln Gln Asp 
465                 470                 475                 480 


Thr Leu Ser Ser Thr Gly Tyr Ser Pro Gly Thr Arg Lys Arg Lys Ser 
                485                 490                 495     


Arg Lys Pro Ser Leu Cys Gln Ala Thr Ser Ala Thr Pro Thr Glu Gly 
            500                 505                 510         


Pro Gly Asp Leu Leu Val Glu Gln Pro Leu Ala Glu Glu Gln Pro Pro 
        515                 520                 525             


Cys Gly Thr Ser Leu Ala Pro Val Lys Arg Ala Glu Gly Glu Ala Glu 
    530                 535                 540                 


Gly Ala Arg Gly Ala Ala Glu Pro Phe Leu Ala Gln Ala Arg Leu Ala 
545                 550                 555                 560 


Trp Glu Ala Gln Gln Ala His Phe His Met Lys Gln Arg Ser Ser Trp 
                565                 570                 575     


Asp Ser Gln Gln Asp Gly Ser Gly Tyr Glu Ser Asp Gly Ala Leu Pro 
            580                 585                 590         


Leu Pro Met Pro Gly Pro Val Val Arg Ala Phe Ser Glu Asp Glu Ala 
        595                 600                 605             


Leu Ala Gln Gln Glu Asn Arg His Trp Arg Arg Gly Thr Phe Glu Lys 
    610                 615                 620                 


Leu Gly Phe Pro Gln Ile Leu Leu Glu Lys Ser Val Ser Val Gln Thr 
625                 630                 635                 640 


Asn Leu Ala Ser Pro Glu Pro Tyr Leu His Pro Ser Gln Ser Glu Asp 
                645                 650                 655     


Leu Ala Ala Cys Ala Gln Phe Glu Ser Ser Arg Gln Ser Arg Ser Gly 
            660                 665                 670         


Val Pro Ser Ser Ser Cys Val Phe Pro Thr Phe Thr Leu Arg Lys Pro 
        675                 680                 685             


Ser Ser Glu Thr Asp Ile Glu Asn Trp Ala Ser Lys His Phe Asn Lys 
    690                 695                 700                 


His Thr Gln Gly Leu Phe Arg Arg Lys Val Ser Ile Ala Asn Met Leu 
705                 710                 715                 720 


Ala Trp Ser Ser Glu Ser Ile Lys Lys Pro Met Ile Val Thr Ser Asp 
                725                 730                 735     


Arg His Val Lys Lys Glu Ala Cys Glu Leu Phe Lys Leu Ile Gln Met 
            740                 745                 750         


Tyr Met Gly Asp Arg Arg Ala Lys Ala Asp Pro Leu His Val Ala Leu 
        755                 760                 765             


Glu Val Ala Thr Lys Gly Trp Ser Val Gln Gly Leu Arg Asp Glu Leu 
    770                 775                 780                 


Tyr Ile Gln Leu Cys Arg Gln Thr Thr Glu Asn Phe Arg Leu Glu Ser 
785                 790                 795                 800 


Leu Ala Arg Gly Trp Glu Leu Met Ala Ile Cys Leu Ala Phe Phe Pro 
                805                 810                 815     


Pro Thr Pro Lys Phe His Ser Tyr Leu Glu Gly Tyr Ile Tyr Arg His 
            820                 825                 830         


Met Asp Pro Val Asn Asp Thr Lys Gly Val Ala Ile Ser Thr Tyr Ala 
        835                 840                 845             


Lys Tyr Cys Tyr His Lys Leu Gln Lys Ala Ala Leu Thr Gly Ala Lys 
    850                 855                 860                 


Lys Gly Leu Lys Lys Pro Asn Val Glu Glu Ile Arg His Ala Lys Asn 
865                 870                 875                 880 


Ala Val Phe Ser Pro Ser Met Phe Gly Ser Ala Leu Gln Glu Val Met 
                885                 890                 895     


Gly Met Gln Arg Glu Arg Tyr Pro Glu Arg Gln Leu Pro Trp Val Gln 
            900                 905                 910         


Thr Arg Leu Ser Glu Glu Val Leu Ala Leu Asn Gly Asp Gln Thr Glu 
        915                 920                 925             


Gly Ile Phe Arg Val Pro Gly Asp Ile Asp Glu Val Asn Ala Leu Lys 
    930                 935                 940                 


Leu Gln Val Asp Gln Trp Lys Val Pro Thr Gly Leu Glu Asp Pro His 
945                 950                 955                 960 


Val Pro Ala Ser Leu Leu Lys Leu Trp Tyr Arg Glu Leu Glu Glu Pro 
                965                 970                 975     


Leu Ile Pro His Glu Phe Tyr Glu Gln Cys Ile Ala His Tyr Asp Ser 
            980                 985                 990         


Pro Glu Ala Ala Val Ala Val Val  His Ala Leu Pro Arg  Ile Asn Arg 
        995                 1000                 1005             


Met Val  Leu Cys Tyr Leu Ile  Arg Phe Leu Gln Val  Phe Val Gln 
    1010                 1015                 1020             


Pro Ala  Asn Val Ala Val Thr  Lys Met Asp Val Ser  Asn Leu Ala 
    1025                 1030                 1035             


Met Val  Met Ala Pro Asn Cys  Leu Arg Cys Gln Ser  Asp Asp Pro 
    1040                 1045                 1050             


Arg Val  Ile Phe Glu Asn Thr  Arg Lys Glu Met Ser  Phe Leu Arg 
    1055                 1060                 1065             


Val Leu  Ile Gln His Leu Asp  Thr Ser Phe Met Glu  Gly Val Leu 
    1070                 1075                 1080             


<210> 8833
<211> 500
<212> PRT
<213> Homo sapiens

<400> 8833
Met Ala Ala Val Lys Thr Leu Asn Pro Lys Gly Thr Met Lys Met Leu 
1               5                   10                  15      


Val Ser Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu 
            20                  25                  30          


Leu His Glu Met Gln Ile Gln His Pro Thr Ala Ser Leu Ile Ala Lys 
        35                  40                  45              


Val Ala Thr Ala Gln Asp Asp Ile Thr Gly Asp Gly Thr Thr Ser Asn 
    50                  55                  60                  


Val Leu Ile Ile Gly Glu Leu Leu Lys Gln Ala Asp Leu Tyr Ile Ser 
65                  70                  75                  80  


Glu Gly Leu His Pro Arg Ile Ile Thr Glu Gly Phe Glu Ala Ala Lys 
                85                  90                  95      


Glu Lys Ala Leu Gln Phe Leu Glu Glu Val Lys Val Ser Arg Glu Met 
            100                 105                 110         


Asp Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg Thr Lys 
        115                 120                 125             


Val His Ala Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val Asp Ser 
    130                 135                 140                 


Ile Leu Ala Ile Lys Lys Gln Asp Glu Pro Ile Asp Leu Phe Met Ile 
145                 150                 155                 160 


Glu Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser Leu Ile 
                165                 170                 175     


Arg Gly Leu Val Leu Asp His Gly Ala Arg His Pro Asp Met Lys Lys 
            180                 185                 190         


Arg Val Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu Glu Tyr 
        195                 200                 205             


Glu Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala Glu Glu 
    210                 215                 220                 


Arg Glu Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp Arg Val 
225                 230                 235                 240 


Lys Lys Ile Ile Glu Leu Lys Arg Lys Val Cys Gly Asp Ser Asp Lys 
                245                 250                 255     


Gly Phe Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser Leu Asp 
            260                 265                 270         


Ala Leu Ser Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys Arg Arg 
        275                 280                 285             


Asn Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Val Ala Leu Asn Ser 
    290                 295                 300                 


Phe Asp Asp Leu Ser Pro Asp Cys Leu Gly His Ala Gly Leu Val Tyr 
305                 310                 315                 320 


Glu Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys Cys Asn 
                325                 330                 335     


Asn Pro Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn Lys His Thr 
            340                 345                 350         


Leu Thr Gln Ile Lys Asp Ala Val Arg Asp Gly Leu Arg Ala Val Lys 
        355                 360                 365             


Asn Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala Val Glu 
    370                 375                 380                 


Val Ala Met Ala Glu Ala Leu Ile Lys His Lys Pro Ser Val Lys Gly 
385                 390                 395                 400 


Arg Ala Gln Leu Gly Val Gln Ala Phe Ala Asp Ala Leu Leu Ile Ile 
                405                 410                 415     


Pro Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu Thr Leu 
            420                 425                 430         


Val Lys Ile Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val Gly Val 
        435                 440                 445             


Asp Leu Asn Thr Gly Glu Pro Met Val Ala Ala Glu Val Gly Val Trp 
    450                 455                 460                 


Asp Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr Val Ile 
465                 470                 475                 480 


Ala Thr Asn Ile Leu Leu Val Asp Glu Ile Met Arg Ala Gly Met Ser 
                485                 490                 495     


Ser Leu Lys Gly 
            500 


<210> 8834
<211> 513
<212> PRT
<213> Homo sapiens

<400> 8834
Met Trp Asp Val Cys Met Glu Arg Gly His Arg Asp Leu Glu Gln Phe 
1               5                   10                  15      


Glu Arg Val His Arg Tyr Ile Ser Asp Gln Leu Phe Thr Asn Phe Lys 
            20                  25                  30          


Glu Arg Thr Glu Arg Leu Val Ile Ser Pro Leu Asn Gln Leu Leu Ser 
        35                  40                  45              


Met Phe Thr Gly Pro His Lys Leu Val Gln Lys Arg Phe Asp Lys Leu 
    50                  55                  60                  


Leu Asp Phe Tyr Asn Cys Thr Glu Arg Ala Glu Lys Leu Lys Asp Lys 
65                  70                  75                  80  


Lys Thr Leu Glu Glu Leu Gln Ser Ala Arg Asn Asn Tyr Glu Ala Leu 
                85                  90                  95      


Asn Ala Gln Leu Leu Asp Glu Leu Pro Lys Phe His Gln Tyr Ala Gln 
            100                 105                 110         


Gly Leu Phe Thr Asn Cys Val His Gly Tyr Ala Glu Ala His Cys Asp 
        115                 120                 125             


Phe Val His Gln Ala Leu Glu Gln Leu Lys Pro Leu Leu Ser Leu Leu 
    130                 135                 140                 


Lys Val Ala Gly Arg Glu Gly Asn Leu Ile Ala Ile Phe His Glu Glu 
145                 150                 155                 160 


His Ser Arg Val Leu Gln Gln Leu Gln Val Phe Thr Phe Phe Pro Glu 
                165                 170                 175     


Ser Leu Pro Ala Thr Lys Lys Pro Phe Glu Arg Lys Thr Ile Asp Arg 
            180                 185                 190         


Gln Ser Ala Arg Lys Pro Leu Leu Gly Leu Pro Ser Tyr Met Leu Gln 
        195                 200                 205             


Ser Glu Glu Leu Arg Ala Ser Leu Leu Ala Arg Tyr Pro Pro Glu Lys 
    210                 215                 220                 


Leu Phe Gln Ala Glu Arg Asn Phe Asn Ala Ala Gln Asp Leu Asp Val 
225                 230                 235                 240 


Ser Leu Leu Glu Gly Asp Leu Val Gly Val Ile Lys Lys Lys Asp Pro 
                245                 250                 255     


Met Gly Ser Gln Asn Arg Trp Leu Ile Asp Asn Gly Val Thr Lys Gly 
            260                 265                 270         


Phe Val Tyr Ser Ser Phe Leu Lys Pro Tyr Asn Pro Arg Arg Ser His 
        275                 280                 285             


Ser Asp Ala Ser Val Gly Ser His Ser Ser Thr Glu Ser Glu His Gly 
    290                 295                 300                 


Ser Ser Ser Pro Arg Phe Pro Arg Gln Asn Ser Gly Ser Thr Leu Thr 
305                 310                 315                 320 


Phe Asn Pro Ser Ser Met Ala Val Ser Phe Thr Ser Gly Ser Cys Gln 
                325                 330                 335     


Lys Gln Pro Gln Asp Ala Ser Pro Pro Pro Lys Glu Cys Asp Gln Gly 
            340                 345                 350         


Thr Leu Ser Ala Ser Leu Asn Pro Ser Asn Ser Glu Ser Ser Pro Ser 
        355                 360                 365             


Arg Cys Pro Ser Asp Pro Asp Ser Thr Ser Gln Pro Arg Ser Gly Asp 
    370                 375                 380                 


Ser Ala Asp Val Ala Arg Asp Val Lys Gln Pro Thr Ala Thr Pro Arg 
385                 390                 395                 400 


Ser Tyr Arg Asn Phe Arg His Pro Glu Ile Val Gly Tyr Ser Val Pro 
                405                 410                 415     


Gly Arg Asn Gly Gln Ser Gln Asp Leu Val Lys Gly Cys Ala Arg Thr 
            420                 425                 430         


Ala Gln Ala Pro Glu Asp Arg Ser Thr Glu Pro Asp Gly Ser Glu Ala 
        435                 440                 445             


Glu Gly Asn Gln Val Tyr Phe Ala Val Tyr Thr Phe Lys Ala Arg Asn 
    450                 455                 460                 


Pro Asn Glu Leu Ser Val Ser Ala Asn Gln Lys Leu Lys Ile Leu Glu 
465                 470                 475                 480 


Phe Lys Asp Val Thr Gly Asn Thr Glu Trp Trp Leu Ala Glu Val Asn 
                485                 490                 495     


Gly Lys Lys Gly Tyr Val Pro Ser Asn Tyr Ile Arg Lys Thr Glu Tyr 
            500                 505                 510         


Thr 
    


<210> 8835
<211> 50
<212> PRT
<213> Homo sapiens

<400> 8835
Met Met Gln Asn Val His Leu Ala Pro Glu Thr Asp Glu Asp Asp Leu 
1               5                   10                  15      


Tyr Ser Gly Tyr Asn Asp Tyr Asn Pro Ile Tyr Asp Ile Glu Glu Leu 
            20                  25                  30          


Glu Asn Asp Ala Ala Phe Gln Gln Ala Val Arg Thr Ser His Gly Arg 
        35                  40                  45              


Arg Pro 
    50  


<210> 8836
<211> 1438
<212> PRT
<213> Homo sapiens

<400> 8836
Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95      


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110         


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125             


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140                 


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175     


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190         


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205             


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220                 


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240 


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255     


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270         


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285             


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300                 


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320 


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 
                325                 330                 335     


Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala 
            340                 345                 350         


Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu Leu 
        355                 360                 365             


Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser His 
    370                 375                 380                 


Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala Arg Asp Gly His Asp 
385                 390                 395                 400 


Gln His Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met 
                405                 410                 415     


Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 
            420                 425                 430         


Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 
        435                 440                 445             


Ser Ile Thr Lys Gly Asp Leu Glu Gln Lys Ser Gln Ile Ser Glu Asp 
    450                 455                 460                 


Pro Glu Asn Thr Gln Thr Lys Leu Glu His Ala Arg Ile Lys Glu Leu 
465                 470                 475                 480 


Glu Gln Ser Leu Leu Phe Glu Lys Thr Lys Ala Asp Lys Leu Gln Arg 
                485                 490                 495     


Glu Leu Glu Asp Thr Arg Val Ala Thr Val Ser Glu Lys Ser Arg Ile 
            500                 505                 510         


Met Glu Leu Glu Lys Asp Leu Ala Leu Arg Val Gln Glu Val Ala Glu 
        515                 520                 525             


Leu Arg Arg Arg Leu Glu Ser Asn Lys Pro Ala Gly Asp Val Asp Met 
    530                 535                 540                 


Ser Leu Ser Leu Leu Gln Glu Ile Ser Ser Leu Gln Glu Lys Leu Glu 
545                 550                 555                 560 


Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr Ser Leu Lys Glu His 
                565                 570                 575     


Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu Ile Lys Ala Leu Tyr 
            580                 585                 590         


Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu Ser Leu Lys Ser Lys 
        595                 600                 605             


Leu Glu His Ala Asn Lys Glu Asn Ser Asp Val Ile Ala Leu Trp Lys 
    610                 615                 620                 


Ser Lys Leu Glu Thr Ala Ile Ala Ser His Gln Gln Ala Met Glu Glu 
625                 630                 635                 640 


Leu Lys Val Ser Phe Ser Lys Gly Leu Gly Thr Glu Thr Ala Glu Phe 
                645                 650                 655     


Ala Glu Leu Lys Thr Gln Ile Glu Lys Met Arg Leu Asp Tyr Gln His 
            660                 665                 670         


Glu Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser Glu Arg Ala Ala His 
        675                 680                 685             


Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu Met Lys Val Ile Lys 
    690                 695                 700                 


Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser Lys Leu Asp Lys Ala 
705                 710                 715                 720 


Glu Asp Gln His Leu Val Glu Met Glu Asp Thr Leu Asn Lys Leu Gln 
                725                 730                 735     


Glu Ala Glu Ile Lys Val Lys Glu Leu Glu Val Leu Gln Ala Lys Cys 
            740                 745                 750         


Asn Glu Gln Thr Lys Val Ile Asp Asn Phe Thr Ser Gln Leu Lys Ala 
        755                 760                 765             


Thr Glu Glu Lys Leu Leu Asp Leu Asp Ala Leu Arg Lys Ala Ser Ser 
    770                 775                 780                 


Glu Gly Lys Ser Glu Met Lys Lys Leu Arg Gln Gln Leu Glu Ala Ala 
785                 790                 795                 800 


Glu Lys Gln Ile Lys His Leu Glu Ile Glu Lys Asn Ala Glu Ser Ser 
                805                 810                 815     


Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly Arg Glu Leu Lys Leu 
            820                 825                 830         


Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser Gln Val Lys Glu Thr 
        835                 840                 845             


Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys Phe Ala Glu Ala Ser 
    850                 855                 860                 


Glu Glu Ala Val Ser Val Gln Arg Ser Met Gln Glu Thr Val Asn Lys 
865                 870                 875                 880 


Leu His Gln Lys Glu Glu Gln Phe Asn Met Leu Ser Ser Asp Leu Glu 
                885                 890                 895     


Lys Leu Arg Glu Asn Leu Ala Asp Met Glu Ala Lys Phe Arg Glu Lys 
            900                 905                 910         


Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys Glu Lys Leu Glu Asn 
        915                 920                 925             


Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp Asn Ser Ser Gln Leu 
    930                 935                 940                 


Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu Arg Asp Val Glu Glu 
945                 950                 955                 960 


Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn Ala Ser Phe Leu Gln 
                965                 970                 975     


Lys Ser Ile Glu Asp Met Thr Val Lys Ala Glu Gln Ser Gln Gln Glu 
            980                 985                 990         


Ala Ala Lys Lys His Glu Glu Glu  Lys Lys Glu Leu Glu  Arg Lys Leu 
        995                 1000                 1005             


Ser Asp  Leu Glu Lys Lys Met  Glu Thr Ser His Asn  Gln Cys Gln 
    1010                 1015                 1020             


Glu Leu  Lys Ala Arg Tyr Glu  Arg Ala Thr Ser Glu  Thr Lys Thr 
    1025                 1030                 1035             


Lys His  Glu Glu Ile Leu Gln  Asn Leu Gln Lys Thr  Leu Leu Asp 
    1040                 1045                 1050             


Thr Glu  Asp Lys Leu Lys Gly  Ala Arg Glu Glu Asn  Ser Gly Leu 
    1055                 1060                 1065             


Leu Gln  Glu Leu Glu Glu Leu  Arg Lys Gln Ala Asp  Lys Ala Lys 
    1070                 1075                 1080             


Ala Ala  Gln Thr Ala Glu Asp  Ala Met Gln Ile Met  Glu Gln Met 
    1085                 1090                 1095             


Thr Lys  Glu Lys Thr Glu Thr  Leu Ala Ser Leu Glu  Asp Thr Lys 
    1100                 1105                 1110             


Gln Thr  Asn Ala Lys Leu Gln  Asn Glu Leu Asp Thr  Leu Lys Glu 
    1115                 1120                 1125             


Asn Asn  Leu Lys Asn Val Glu  Glu Leu Asn Lys Ser  Lys Glu Leu 
    1130                 1135                 1140             


Leu Thr  Val Glu Asn Gln Lys  Met Glu Glu Phe Arg  Lys Glu Ile 
    1145                 1150                 1155             


Glu Thr  Leu Lys Gln Ala Ala  Ala Gln Lys Ser Gln  Gln Leu Ser 
    1160                 1165                 1170             


Ala Leu  Gln Glu Glu Asn Val  Lys Leu Ala Glu Glu  Leu Gly Arg 
    1175                 1180                 1185             


Ser Arg  Asp Glu Val Thr Ser  His Gln Lys Leu Glu  Glu Glu Arg 
    1190                 1195                 1200             


Ser Val  Leu Asn Asn Gln Leu  Leu Glu Met Lys Lys  Arg Glu Ser 
    1205                 1210                 1215             


Lys Phe  Ile Lys Asp Ala Asp  Glu Glu Lys Ala Ser  Leu Gln Lys 
    1220                 1225                 1230             


Ser Ile  Ser Ile Thr Ser Ala  Leu Leu Thr Glu Lys  Asp Ala Glu 
    1235                 1240                 1245             


Leu Glu  Lys Leu Arg Asn Glu  Val Thr Val Leu Arg  Gly Glu Asn 
    1250                 1255                 1260             


Ala Ser  Ala Lys Ser Leu His  Ser Val Val Gln Thr  Leu Glu Ser 
    1265                 1270                 1275             


Asp Lys  Val Lys Leu Glu Leu  Lys Val Lys Asn Leu  Glu Leu Gln 
    1280                 1285                 1290             


Leu Lys  Glu Asn Lys Arg Gln  Leu Ser Ser Ser Ser  Gly Asn Thr 
    1295                 1300                 1305             


Asp Thr  Gln Ala Asp Glu Asp  Glu Arg Ala Gln Glu  Ser Gln Ile 
    1310                 1315                 1320             


Asp Phe  Leu Asn Ser Val Ile  Val Asp Leu Gln Arg  Lys Asn Gln 
    1325                 1330                 1335             


Asp Leu  Lys Met Lys Val Glu  Met Met Ser Glu Ala  Ala Leu Asn 
    1340                 1345                 1350             


Gly Asn  Gly Asp Asp Leu Asn  Asn Tyr Asp Ser Asp  Asp Gln Glu 
    1355                 1360                 1365             


Lys Gln  Ser Lys Lys Lys Pro  Arg Leu Phe Cys Asp  Ile Cys Asp 
    1370                 1375                 1380             


Cys Phe  Asp Leu His Asp Thr  Glu Asp Cys Pro Thr  Gln Ala Gln 
    1385                 1390                 1395             


Met Ser  Glu Asp Pro Pro His  Ser Thr His His Gly  Ser Arg Gly 
    1400                 1405                 1410             


Glu Glu  Arg Pro Tyr Cys Glu  Ile Cys Glu Met Phe  Gly His Trp 
    1415                 1420                 1425             


Ala Thr  Asn Cys Asn Asp Asp  Glu Thr Phe 
    1430                 1435             


<210> 8837
<211> 211
<212> PRT
<213> Homo sapiens

<400> 8837
Met Ala Phe Ala Asp Ser His Leu Trp Lys Leu Leu Asp Arg His Ala 
1               5                   10                  15      


Asn Thr Ile Arg Leu Phe Val Leu Leu Pro Glu Gln Ser Pro Val Ser 
            20                  25                  30          


Tyr Ser Lys Arg Thr Ala Tyr Gln Lys Ala Gly Gly Asp Ser Gly Asn 
        35                  40                  45              


Val Asp Asp Asp Cys Glu Arg Val Lys Gly Pro Val Gly Ser Leu Lys 
    50                  55                  60                  


Ser Val Glu Ala Ile Leu Glu Glu Ser Thr Glu Lys Leu Lys Ser Leu 
65                  70                  75                  80  


Ser Leu Gln Gln Gln Gln Asp Gly Asp Asn Gly Asp Ser Ser Lys Ser 
                85                  90                  95      


Thr Glu Thr Ser Asp Phe Glu Asn Ile Glu Ser Pro Leu Asn Glu Arg 
            100                 105                 110         


Asp Ser Ser Ala Ser Val Asp Asn Arg Glu Leu Glu Gln His Ile Gln 
        115                 120                 125             


Thr Ser Asp Pro Glu Asn Phe Gln Ser Glu Glu Arg Ser Asp Ser Asp 
    130                 135                 140                 


Val Asn Asn Asp Arg Ser Thr Ser Ser Val Asp Ser Asp Ile Leu Ser 
145                 150                 155                 160 


Ser Ser His Ser Ser Asp Thr Leu Cys Asn Ala Asp Asn Ala Gln Ile 
                165                 170                 175     


Pro Leu Ala Asn Gly Leu Asp Ser His Ser Ile Thr Ser Ser Arg Arg 
            180                 185                 190         


Thr Lys Ala Asn Arg Glu Lys Arg Asn Met Gly Tyr Ser Arg Arg Arg 
        195                 200                 205             


Leu Trp Asn 
    210     


<210> 8838
<211> 711
<212> PRT
<213> Homo sapiens

<400> 8838
Met Leu Ala Ser Leu Lys Val Lys Lys Gln Glu Leu Ala Asn Ser Ser 
1               5                   10                  15      


Asp Ala Thr Leu Pro Asp Arg Pro Leu Ser Pro Pro Leu Thr Ala Pro 
            20                  25                  30          


Pro Thr Met Lys Ser Ser Glu Phe Phe Glu Met Leu Glu Lys Met Gln 
        35                  40                  45              


Gly Ile Lys Leu Glu Glu Gln Lys Pro Gly Pro Gln Lys Asn Lys Asp 
    50                  55                  60                  


Asp Tyr Ile Pro Tyr Pro Ser Ile Asp Glu Val Val Glu Lys Gly Gly 
65                  70                  75                  80  


Pro Tyr Pro Gln Val Ile Leu Pro Gln Phe Gly Gly Tyr Trp Ile Glu 
                85                  90                  95      


Asp Pro Glu Asn Val Gly Thr Pro Thr Ser Leu Gly Ser Ser Ile Cys 
            100                 105                 110         


Glu Glu Glu Glu Glu Asp Asn Leu Ser Pro Asn Thr Phe Gly Tyr Lys 
        115                 120                 125             


Leu Glu Cys Lys Gly Glu Ala Arg Ala Tyr Arg Arg His Phe Leu Gly 
    130                 135                 140                 


Lys Asp His Leu Asn Phe Tyr Cys Thr Gly Ser Ser Leu Gly Asn Leu 
145                 150                 155                 160 


Ile Leu Ser Val Lys Cys Glu Glu Ala Glu Gly Ile Glu Tyr Leu Arg 
                165                 170                 175     


Val Ile Leu Arg Ser Lys Leu Lys Thr Val His Glu Arg Ile Pro Leu 
            180                 185                 190         


Ala Gly Leu Ser Lys Leu Pro Ser Val Pro Gln Ile Ala Lys Ala Phe 
        195                 200                 205             


Cys Asp Asp Ala Val Gly Leu Arg Phe Asn Pro Val Leu Tyr Pro Lys 
    210                 215                 220                 


Ala Ser Gln Met Ile Val Ser Tyr Asp Glu His Glu Val Asn Asn Thr 
225                 230                 235                 240 


Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala Arg Gln Thr Leu Glu Glu 
                245                 250                 255     


Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro Ala Phe Lys Glu Phe Leu 
            260                 265                 270         


Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln Asp Phe Lys Gly Phe Arg 
        275                 280                 285             


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Val Glu Ser Val Tyr 
    290                 295                 300                 


Thr Thr Phe Arg Asp Arg Glu Ile Met Phe His Val Ser Thr Lys Leu 
305                 310                 315                 320 


Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
                325                 330                 335     


Gly Asn Asp Ile Val Ala Ile Ile Phe Gln Glu Glu Asn Thr Pro Phe 
            340                 345                 350         


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Ile Val Val 
        355                 360                 365             


Gln Val Glu Thr Pro Gly Thr Glu Thr Pro Ser Tyr Lys Val Ser Val 
    370                 375                 380                 


Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro Pro Leu Pro Ser Pro 
385                 390                 395                 400 


Pro Val Phe Gln Lys Gly Pro Glu Phe Arg Glu Phe Leu Leu Thr Lys 
                405                 410                 415     


Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser Asp Lys Phe Ala Lys 
            420                 425                 430         


Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp Asn Leu His Asp Glu 
        435                 440                 445             


Leu His Ala His Thr Gln Ala Met Leu Gly Leu Gly Pro Glu Glu Asp 
    450                 455                 460                 


Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu Glu Ser Phe Lys Arg 
465                 470                 475                 480 


Ala Ile Arg Val Arg Ser His Ser Met Glu Thr Met Val Gly Gly Gln 
                485                 490                 495     


Lys Lys Ser His Ser Gly Gly Ile Pro Gly Ser Leu Ser Gly Gly Ile 
            500                 505                 510         


Ser His Asn Ser Met Glu Val Thr Lys Thr Thr Phe Ser Pro Pro Val 
        515                 520                 525             


Val Ala Ala Thr Val Lys Asn Gln Ser Arg Ser Pro Ile Lys Arg Arg 
    530                 535                 540                 


Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser Glu Gly Gln Gly Asp 
545                 550                 555                 560 


Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr Pro Lys Thr Pro Asp 
                565                 570                 575     


Gly Gly His Ser Ser Gln Glu Ile Lys Ser Glu Thr Ser Ser Asn Pro 
            580                 585                 590         


Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu Lys Pro Phe Met Lys Leu 
        595                 600                 605             


Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser Ser Ser Ser Thr Ser Ser 
    610                 615                 620                 


Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met Glu Glu Gly Asp Ser 
625                 630                 635                 640 


Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro Phe Lys Gln Glu Val Phe 
                645                 650                 655     


Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro Ser Leu Gly Ala Ala 
            660                 665                 670         


Ala Thr Pro Ile Ile Met Ser Arg Ser Pro Thr Asp Ala Lys Ser Arg 
        675                 680                 685             


Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe Asp Lys Leu Ser His 
    690                 695                 700                 


Ala Ser Ser Gly Ala Gly His 
705                 710     


<210> 8839
<211> 362
<212> PRT
<213> Homo sapiens

<400> 8839
Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu Tyr Tyr Asn Gln 
1               5                   10                  15      


Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Thr Glu Ala Ile Ser Val 
            20                  25                  30          


Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu Glu Lys Phe Ala 
        35                  40                  45              


Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile Leu Thr Tyr Gln 
    50                  55                  60                  


Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu Lys Met Ile Ser 
65                  70                  75                  80  


Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Thr Gly Asn Asn Asn 
                85                  90                  95      


Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly Ala Leu Ile Glu 
            100                 105                 110         


Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg Ala Tyr Ile Gln 
        115                 120                 125             


Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys Ser Val Met Asn 
    130                 135                 140                 


Thr Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys Ser Asn Phe Glu 
145                 150                 155                 160 


Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu Leu Asn Ser Ser 
                165                 170                 175     


Asn Ile Ala Glu His Pro Gly Phe Met Lys Thr Gly Glu Cys Leu Arg 
            180                 185                 190         


Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe Ala Met Ser Lys 
        195                 200                 205             


His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu Gln Glu Asn Asp 
    210                 215                 220                 


Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Thr Asp Pro Gly Lys Lys 
225                 230                 235                 240 


Phe Ser Gly Arg Pro Met Cys Thr Leu Leu Thr Asn Lys Arg Tyr Glu 
                245                 250                 255     


Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile Gly Arg Pro Leu 
            260                 265                 270         


Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val Tyr His Ala Asn 
        275                 280                 285             


Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile Ala Ala Asn Lys 
    290                 295                 300                 


Gly Thr Ser Glu Gln Glu Thr Lys Gly Leu Pro Ser Lys Lys Gly Ile 
305                 310                 315                 320 


Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys Ile Val Leu Ala 
                325                 330                 335     


Ser Gln Ser Ile Gln Asn Thr Val Tyr Asn Asp Gly Gln Ser Ser Ala 
            340                 345                 350         


Ile Pro Val Ala Lys Ala Gly Lys Trp Gly 
        355                 360         


<210> 8840
<211> 606
<212> PRT
<213> Homo sapiens

<400> 8840
Met Cys Gly Ala Gly Phe Gly His Phe Glu Trp Leu Ala Gly Gly Gly 
1               5                   10                  15      


Ala Gly Gln Asp Val Gly Arg Ser Cys Ile Leu Val Ser Ile Ala Gly 
            20                  25                  30          


Lys Asn Val Met Leu Asp Cys Gly Met His Met Gly Phe Asn Asp Asp 
        35                  40                  45              


Arg Arg Phe Pro Asp Phe Ser Tyr Ile Thr Gln Asn Gly Arg Leu Thr 
    50                  55                  60                  


Asp Phe Leu Asp Cys Val Ile Ile Ser His Phe His Leu Asp His Cys 
65                  70                  75                  80  


Gly Ala Leu Pro Tyr Phe Ser Glu Met Val Gly Tyr Asp Gly Pro Ile 
                85                  90                  95      


Tyr Met Thr His Pro Thr Gln Ala Ile Cys Pro Ile Leu Leu Glu Asp 
            100                 105                 110         


Tyr Arg Lys Ile Ala Val Asp Lys Lys Gly Glu Ala Asn Phe Phe Thr 
        115                 120                 125             


Ser Gln Met Ile Lys Asp Cys Met Lys Lys Val Val Ala Val His Leu 
    130                 135                 140                 


His Gln Thr Val Gln Val Asp Asp Glu Leu Glu Ile Lys Ala Tyr Tyr 
145                 150                 155                 160 


Ala Gly His Val Leu Gly Ala Ala Met Phe Gln Ile Lys Val Gly Ser 
                165                 170                 175     


Glu Ser Val Val Tyr Thr Gly Asp Tyr Asn Met Thr Pro Asp Arg His 
            180                 185                 190         


Leu Gly Ala Ala Trp Ile Asp Lys Cys Arg Pro Asn Leu Leu Ile Thr 
        195                 200                 205             


Glu Ser Thr Tyr Ala Thr Thr Ile Arg Asp Ser Lys Arg Cys Arg Glu 
    210                 215                 220                 


Arg Asp Phe Leu Lys Lys Val His Glu Thr Val Glu Arg Gly Gly Lys 
225                 230                 235                 240 


Val Leu Ile Pro Val Phe Ala Leu Gly Arg Ala Gln Glu Leu Cys Ile 
                245                 250                 255     


Leu Leu Glu Thr Phe Trp Glu Arg Met Asn Leu Lys Val Pro Ile Tyr 
            260                 265                 270         


Phe Ser Thr Gly Leu Thr Glu Lys Ala Asn His Tyr Tyr Lys Leu Phe 
        275                 280                 285             


Ile Pro Trp Thr Asn Gln Lys Ile Arg Lys Thr Phe Val Gln Arg Asn 
    290                 295                 300                 


Met Phe Glu Phe Lys His Ile Lys Ala Phe Asp Arg Ala Phe Ala Asp 
305                 310                 315                 320 


Asn Pro Gly Pro Met Val Val Phe Ala Thr Pro Gly Met Leu His Ala 
                325                 330                 335     


Gly Gln Ser Leu Gln Ile Phe Arg Lys Trp Ala Gly Asn Glu Lys Asn 
            340                 345                 350         


Met Val Ile Met Pro Gly Tyr Cys Val Gln Gly Thr Val Gly His Lys 
        355                 360                 365             


Ile Leu Ser Gly Gln Arg Lys Leu Glu Met Glu Gly Arg Gln Val Leu 
    370                 375                 380                 


Glu Val Lys Met Gln Val Glu Tyr Met Ser Phe Ser Ala His Ala Asp 
385                 390                 395                 400 


Ala Lys Gly Ile Met Gln Leu Val Gly Gln Ala Glu Pro Glu Ser Val 
                405                 410                 415     


Leu Leu Val His Gly Glu Ala Lys Lys Met Glu Phe Leu Lys Gln Lys 
            420                 425                 430         


Ile Glu Gln Glu Leu Arg Val Asn Cys Tyr Met Pro Ala Asn Gly Glu 
        435                 440                 445             


Thr Val Thr Leu Pro Thr Ser Pro Ser Ile Pro Val Gly Ile Ser Leu 
    450                 455                 460                 


Gly Leu Leu Lys Arg Glu Met Ala Gln Gly Leu Leu Pro Glu Ala Lys 
465                 470                 475                 480 


Lys Pro Arg Leu Leu His Gly Thr Leu Ile Met Lys Asp Ser Asn Phe 
                485                 490                 495     


Arg Leu Val Ser Ser Glu Gln Ala Leu Lys Glu Leu Gly Leu Ala Glu 
            500                 505                 510         


His Gln Leu Arg Phe Thr Cys Arg Val His Leu His Asp Thr Arg Lys 
        515                 520                 525             


Glu Gln Glu Thr Ala Leu Arg Val Tyr Ser His Leu Lys Ser Val Leu 
    530                 535                 540                 


Lys Asp His Cys Val Gln His Leu Pro Asp Gly Ser Val Thr Val Glu 
545                 550                 555                 560 


Ser Val Leu Leu Gln Ala Ala Ala Pro Ser Glu Asp Pro Gly Thr Lys 
                565                 570                 575     


Val Leu Leu Val Ser Trp Thr Tyr Gln Asp Glu Glu Leu Gly Ser Phe 
            580                 585                 590         


Leu Thr Ser Leu Leu Lys Lys Gly Leu Pro Gln Ala Pro Ser 
        595                 600                 605     


<210> 8841
<211> 132
<212> PRT
<213> Homo sapiens

<400> 8841
Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val 
1               5                   10                  15      


Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg 
            20                  25                  30          


Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp 
        35                  40                  45              


Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val 
    50                  55                  60                  


Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe 
65                  70                  75                  80  


Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu 
                85                  90                  95      


Phe Glu Leu Gln Ile Leu Thr Trp Phe Asn Val Met Cys Ala Tyr Tyr 
            100                 105                 110         


Leu Thr Glu Cys Pro Ser His Ser Ile Gln Asn Tyr Glu Ser Ser Leu 
        115                 120                 125             


Trp Asp Gln Lys 
    130         


<210> 8842
<211> 456
<212> PRT
<213> Homo sapiens

<400> 8842
Met Met Val Gly Asp Gly Thr Thr Ser Val Thr Leu Leu Ala Ala Glu 
1               5                   10                  15      


Phe Leu Lys Gln Val Lys Pro Tyr Val Glu Glu Gly Leu His Pro Gln 
            20                  25                  30          


Ile Ile Ile Arg Ala Phe Arg Thr Ala Thr Gln Leu Ala Val Asn Lys 
        35                  40                  45              


Ile Lys Glu Ile Ala Val Thr Val Lys Lys Ala Asp Lys Val Glu Gln 
    50                  55                  60                  


Arg Lys Leu Leu Glu Lys Cys Ala Met Thr Ala Leu Ser Ser Lys Leu 
65                  70                  75                  80  


Ile Ser Gln Gln Lys Ala Phe Phe Ala Lys Met Val Val Asp Ala Val 
                85                  90                  95      


Met Met Leu Asp Asp Leu Leu Gln Leu Lys Met Ile Gly Ile Lys Lys 
            100                 105                 110         


Val Gln Gly Gly Ala Leu Glu Asp Ser Gln Leu Val Ala Gly Val Ala 
        115                 120                 125             


Phe Lys Lys Thr Phe Ser Tyr Ala Gly Phe Glu Met Gln Pro Lys Lys 
    130                 135                 140                 


Tyr His Asn Pro Lys Ile Ala Leu Leu Asn Val Glu Leu Glu Leu Lys 
145                 150                 155                 160 


Ala Glu Lys Asp Asn Ala Glu Ile Arg Val His Thr Val Glu Asp Tyr 
                165                 170                 175     


Gln Ala Ile Val Asp Ala Glu Trp Asn Ile Leu Tyr Asp Lys Leu Glu 
            180                 185                 190         


Lys Ile His His Ser Gly Ala Lys Val Val Leu Ser Lys Leu Pro Ile 
        195                 200                 205             


Gly Asp Val Ala Thr Gln Tyr Phe Ala Asp Arg Asp Met Phe Cys Ala 
    210                 215                 220                 


Gly Arg Val Pro Glu Glu Asp Leu Lys Arg Thr Met Met Ala Cys Gly 
225                 230                 235                 240 


Gly Ser Ile Gln Thr Ser Val Asn Ala Leu Ser Ala Asp Val Leu Gly 
                245                 250                 255     


Arg Cys Gln Val Phe Glu Glu Thr Gln Ile Gly Gly Glu Arg Tyr Asn 
            260                 265                 270         


Phe Phe Thr Gly Cys Pro Lys Ala Lys Thr Cys Thr Phe Ile Leu Arg 
        275                 280                 285             


Gly Gly Ala Glu Gln Phe Met Glu Glu Thr Glu Arg Ser Leu His Asp 
    290                 295                 300                 


Ala Ile Met Ile Val Arg Arg Ala Ile Lys Asn Asp Ser Val Val Ala 
305                 310                 315                 320 


Gly Gly Gly Ala Ile Glu Met Glu Leu Ser Lys Tyr Leu Arg Asp Tyr 
                325                 330                 335     


Ser Arg Thr Ile Pro Gly Lys Gln Gln Leu Leu Ile Gly Ala Tyr Ala 
            340                 345                 350         


Lys Ala Leu Glu Ile Ile Pro Arg Gln Leu Cys Asp Asn Ala Gly Phe 
        355                 360                 365             


Asp Ala Thr Asn Ile Leu Asn Lys Leu Arg Ala Arg His Ala Gln Gly 
    370                 375                 380                 


Gly Thr Trp Tyr Gly Val Asp Ile Asn Asn Glu Asp Ile Ala Asp Asn 
385                 390                 395                 400 


Phe Glu Ala Phe Val Trp Glu Pro Ala Met Val Arg Ile Asn Ala Leu 
                405                 410                 415     


Thr Ala Ala Ser Glu Ala Ala Cys Leu Ile Val Ser Val Asp Glu Thr 
            420                 425                 430         


Ile Lys Asn Pro Arg Ser Thr Val Asp Ala Pro Thr Ala Ala Gly Arg 
        435                 440                 445             


Gly Arg Gly Arg Gly Arg Pro His 
    450                 455     


<210> 8843
<211> 839
<212> PRT
<213> Homo sapiens

<400> 8843
Met Asp Gly Lys Ala Asp Val Lys Ser Leu Met Ala Lys Tyr Asn Thr 
1               5                   10                  15      


Gly Gly Asn Pro Thr Glu Asp Val Ser Val Asn Ser Arg Pro Phe Arg 
            20                  25                  30          


Val Thr Gly Pro Asn Ser Ser Ser Gly Ile Gln Ala Arg Lys Asn Leu 
        35                  40                  45              


Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro Ala Gly Pro Ser Asn Val 
    50                  55                  60                  


Pro Lys Phe Gly Ser Pro Lys Pro Pro Val Ala Val Lys Pro Ser Ser 
65                  70                  75                  80  


Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro Pro Phe Leu Lys Pro Thr 
                85                  90                  95      


Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala Ser Leu Thr Thr Arg Asp 
            100                 105                 110         


Pro Glu Ala Lys Val Gly Phe Leu Lys Pro Val Gly Pro Lys Pro Ile 
        115                 120                 125             


Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr Phe Pro Trp Pro Pro Gly 
    130                 135                 140                 


Asn Lys Pro Ser Leu His Ser Val Asn Gln Asp His Asp Leu Lys Pro 
145                 150                 155                 160 


Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro Thr Ser Glu Asn Glu Gln 
                165                 170                 175     


Lys Gln Ala Phe Pro Lys Leu Thr Gly Val Lys Gly Lys Phe Met Ser 
            180                 185                 190         


Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu Phe Pro Lys Pro Ala Phe 
        195                 200                 205             


Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn Ser His Glu Asp Glu Ser 
    210                 215                 220                 


Pro Met Lys Asn Val Ser Ser Ser Lys Gly Ser Pro Ala Pro Leu Gly 
225                 230                 235                 240 


Val Arg Ser Lys Ser Gly Pro Leu Lys Pro Ala Arg Glu Asp Ser Glu 
                245                 250                 255     


Asn Lys Asp His Ala Gly Glu Ile Ser Ser Leu Pro Phe Pro Gly Val 
            260                 265                 270         


Val Leu Lys Pro Ala Ala Ser Arg Gly Gly Pro Gly Leu Ser Lys Asn 
        275                 280                 285             


Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile Asp Ala Ala Lys Asn Thr 
    290                 295                 300                 


Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu Ala Ser Gly Thr Pro Pro 
305                 310                 315                 320 


Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu Thr Val Gly Gly Pro Trp 
                325                 330                 335     


Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp Lys Asn Ser Ala Thr Pro 
            340                 345                 350         


Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr Leu Gly Pro Pro Pro Pro 
        355                 360                 365             


Lys Pro Asn Arg Pro Pro Asn Val Asp Leu Thr Lys Phe His Lys Thr 
    370                 375                 380                 


Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln Thr Ser Tyr Ser Thr Thr 
385                 390                 395                 400 


Ser Leu Pro Pro Pro Pro Pro Ser His Pro Ala Ser Gln Pro Pro Leu 
                405                 410                 415     


Pro Ala Ser His Pro Ser Gln Pro Pro Val Pro Ser Leu Pro Pro Arg 
            420                 425                 430         


Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser Pro Val Asn Glu Asp Asn 
        435                 440                 445             


Gln Asp Gly Val Thr His Ser Asp Gly Ala Gly Asn Leu Asp Glu Glu 
    450                 455                 460                 


Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp Ile Glu Ala Ser Lys Glu 
465                 470                 475                 480 


Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys Lys Arg Leu Glu Leu Glu 
                485                 490                 495     


Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys Glu Gln Glu Ile Lys Lys 
            500                 505                 510         


Lys Phe Lys Leu Thr Gly Pro Ile Gln Val Ile His Leu Ala Lys Ala 
        515                 520                 525             


Cys Cys Asp Val Lys Gly Gly Lys Asn Glu Leu Ser Phe Lys Gln Gly 
    530                 535                 540                 


Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp Asn Pro Glu Gly Lys Trp 
545                 550                 555                 560 


Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly Tyr Ile Lys Thr Thr Ala 
                565                 570                 575     


Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu Lys Lys Asp Ser Leu Gly 
            580                 585                 590         


Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln Glu Val Tyr Asp Asp Val 
        595                 600                 605             


Ala Glu Gln Asp Asp Ile Ser Ser His Ser Gln Ser Gly Ser Gly Gly 
    610                 615                 620                 


Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile Tyr Asp Gly Ile Glu Glu 
625                 630                 635                 640 


Glu Asp Ala Asp Asp Gly Ser Thr Leu Gln Val Gln Glu Lys Ser Asn 
                645                 650                 655     


Thr Trp Ser Trp Gly Ile Leu Lys Met Leu Lys Gly Lys Asp Asp Arg 
            660                 665                 670         


Lys Lys Ser Ile Arg Glu Lys Pro Lys Val Ser Asp Ser Asp Asn Asn 
        675                 680                 685             


Glu Gly Ser Ser Phe Pro Ala Pro Pro Lys Gln Leu Asp Met Gly Asp 
    690                 695                 700                 


Glu Val Tyr Asp Asp Val Asp Thr Ser Asp Phe Pro Val Ser Ser Ala 
705                 710                 715                 720 


Glu Met Ser Gln Gly Thr Asn Val Gly Lys Ala Lys Thr Glu Glu Lys 
                725                 730                 735     


Asp Leu Lys Lys Leu Lys Lys Gln Glu Lys Glu Glu Lys Asp Phe Arg 
            740                 745                 750         


Lys Lys Phe Lys Tyr Asp Gly Glu Ile Arg Val Leu Tyr Ser Thr Lys 
        755                 760                 765             


Val Thr Thr Ser Ile Thr Ser Lys Lys Trp Gly Thr Arg Asp Leu Gln 
    770                 775                 780                 


Val Lys Pro Gly Glu Ser Leu Glu Val Ile Gln Thr Thr Asp Asp Thr 
785                 790                 795                 800 


Lys Val Leu Cys Arg Asn Glu Glu Gly Lys Tyr Gly Tyr Val Leu Arg 
                805                 810                 815     


Ser Tyr Leu Ala Asp Asn Asp Gly Glu Ile Tyr Asp Asp Ile Ala Asp 
            820                 825                 830         


Gly Cys Ile Tyr Asp Asn Asp 
        835                 


<210> 8844
<211> 338
<212> PRT
<213> Homo sapiens

<400> 8844
Met Gly His Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met 
1               5                   10                  15      


Asp Trp Val Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn 
            20                  25                  30          


Asp Gly Phe Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu 
        35                  40                  45              


Glu Ile Val Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile 
    50                  55                  60                  


Thr Leu Pro Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val 
65                  70                  75                  80  


Gln Phe Ala Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys 
                85                  90                  95      


Glu Arg Ile Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu 
            100                 105                 110         


Glu Val Arg Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln 
        115                 120                 125             


Arg Pro Gly Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly 
    130                 135                 140                 


Ile Val Lys Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser 
145                 150                 155                 160 


Thr Gly Tyr Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr 
                165                 170                 175     


Gly Phe Thr Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser 
            180                 185                 190         


Gly Met Tyr Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser 
        195                 200                 205             


Thr Thr Gly His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr 
    210                 215                 220                 


Glu Asn Asp Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val 
225                 230                 235                 240 


His Ile Glu Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val 
                245                 250                 255     


Glu Phe Ala Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg 
            260                 265                 270         


Ala Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr 
        275                 280                 285             


Gly Ala Ser Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly 
    290                 295                 300                 


Val Ser Ala Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val 
305                 310                 315                 320 


Ser Gly Cys Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly 
                325                 330                 335     


Tyr Asp 
        


<210> 8845
<211> 511
<212> PRT
<213> Homo sapiens

<400> 8845
Met Ala Ser Val Val Glu Tyr Lys Gly Leu Arg Ala Gly Tyr His Cys 
1               5                   10                  15      


Gly Tyr Cys Asp Ser Lys Glu Gly Lys Ala Ser Cys Gly Met Trp Ala 
            20                  25                  30          


His Ser Met Thr Val Gln Asp Tyr Gln Asp Leu Ile Asp Arg Gly Trp 
        35                  40                  45              


Arg Arg Ser Gly Lys Tyr Val Tyr Lys Pro Val Met Asn Gln Thr Cys 
    50                  55                  60                  


Cys Pro Gln Tyr Thr Ile Arg Cys Arg Pro Leu Gln Phe Gln Pro Ser 
65                  70                  75                  80  


Lys Ser His Lys Lys Val Leu Lys Lys Met Leu Lys Phe Leu Ala Lys 
                85                  90                  95      


Gly Glu Val Pro Lys Gly Ser Cys Glu Asp Glu Pro Met Asp Ser Thr 
            100                 105                 110         


Met Asp Asp Ala Val Ala Gly Asp Phe Ala Leu Ile Asn Lys Leu Asp 
        115                 120                 125             


Ile Gln Cys Asp Leu Lys Thr Leu Ser Asp Asp Ile Lys Glu Ser Leu 
    130                 135                 140                 


Glu Ser Glu Gly Lys Asn Ser Lys Lys Glu Glu Pro Gln Glu Leu Leu 
145                 150                 155                 160 


Gln Ser Gln Asp Phe Val Gly Glu Lys Leu Gly Ser Gly Glu Pro Ser 
                165                 170                 175     


His Ser Val Lys Val His Thr Val Pro Lys Pro Gly Lys Gly Ala Asp 
            180                 185                 190         


Leu Ser Lys Pro Pro Cys Arg Lys Ala Lys Glu Ile Arg Lys Glu Arg 
        195                 200                 205             


Lys Arg Leu Lys Leu Met Gln Gln Asn Pro Ala Gly Glu Leu Glu Gly 
    210                 215                 220                 


Phe Gln Ala Gln Gly His Pro Pro Ser Leu Phe Pro Pro Lys Ala Lys 
225                 230                 235                 240 


Ser Asn Gln Pro Lys Ser Leu Glu Asp Leu Ile Phe Glu Ser Leu Pro 
                245                 250                 255     


Glu Asn Ala Ser His Lys Leu Glu Val Arg Leu Val Pro Val Ser Phe 
            260                 265                 270         


Glu Asp Pro Glu Phe Lys Ser Ser Phe Ser Gln Ser Phe Ser Leu Tyr 
        275                 280                 285             


Val Lys Tyr Gln Val Ala Ile His Gln Asp Pro Pro Asp Glu Cys Gly 
    290                 295                 300                 


Lys Thr Glu Phe Thr Arg Phe Leu Cys Ser Ser Pro Leu Glu Ala Glu 
305                 310                 315                 320 


Thr Pro Pro Asn Gly Pro Asp Cys Gly Tyr Gly Ser Phe His Gln Gln 
                325                 330                 335     


Tyr Trp Leu Asp Gly Lys Ile Ile Ala Val Gly Val Ile Asp Ile Leu 
            340                 345                 350         


Pro Asn Cys Val Ser Ser Val Tyr Leu Tyr Tyr Asp Pro Asp Tyr Ser 
        355                 360                 365             


Phe Leu Ser Leu Gly Val Tyr Ser Ala Leu Arg Glu Ile Ala Phe Thr 
    370                 375                 380                 


Arg Gln Leu His Glu Lys Thr Ser Gln Leu Ser Tyr Tyr Tyr Met Gly 
385                 390                 395                 400 


Phe Tyr Ile His Ser Cys Pro Lys Met Lys Tyr Lys Gly Gln Tyr Arg 
                405                 410                 415     


Pro Ser Asp Leu Leu Cys Pro Glu Thr Tyr Val Trp Val Pro Ile Glu 
            420                 425                 430         


Gln Cys Leu Pro Ser Leu Glu Asn Ser Lys Tyr Cys Arg Phe Asn Gln 
        435                 440                 445             


Asp Pro Glu Ala Val Asp Glu Asp Arg Ser Thr Glu Pro Asp Arg Leu 
    450                 455                 460                 


Gln Val Phe His Lys Arg Ala Ile Met Pro Tyr Gly Val Tyr Lys Lys 
465                 470                 475                 480 


Gln Gln Lys Asp Pro Ser Glu Glu Ala Ala Val Leu Gln Tyr Ala Ser 
                485                 490                 495     


Leu Val Gly Gln Lys Cys Ser Glu Arg Met Leu Leu Phe Arg Asn 
            500                 505                 510     


<210> 8846
<211> 1320
<212> PRT
<213> Homo sapiens

<400> 8846
Met Gln Asp Asp Ser Ile Glu Ala Ser Thr Ser Ile Ser Gln Leu Leu 
1               5                   10                  15      


Arg Glu Ser Tyr Leu Ala Glu Thr Arg His Arg Gly Asn Asn Glu Arg 
            20                  25                  30          


Ser Arg Ala Glu Pro Ser Ser Asn Pro Cys His Phe Gly Ser Pro Ser 
        35                  40                  45              


Gly Ala Ala Glu Gly Gly Gly Gly Gln Asp Asp Leu Pro Asp Leu Ser 
    50                  55                  60                  


Ala Phe Leu Ser Gln Glu Glu Leu Asp Glu Ser Val Asn Leu Ala Arg 
65                  70                  75                  80  


Leu Ala Ile Asn Tyr Asp Pro Leu Glu Lys Ala Asp Glu Thr Gln Ala 
                85                  90                  95      


Arg Lys Arg Leu Ser Pro Asp Gln Met Lys His Ser Pro Asn Leu Ser 
            100                 105                 110         


Phe Glu Pro Asn Phe Cys Gln Asp Asn Pro Arg Ser Pro Thr Ser Ser 
        115                 120                 125             


Lys Glu Ser Pro Gln Glu Ala Lys Arg Pro Gln Tyr Cys Ser Glu Thr 
    130                 135                 140                 


Gln Ser Lys Lys Val Phe Leu Asn Lys Ala Ala Asp Phe Ile Glu Glu 
145                 150                 155                 160 


Leu Ser Ser Leu Phe Lys Ser His Ser Ser Lys Arg Ile Arg Pro Arg 
                165                 170                 175     


Ala Cys Lys Asn His Lys Ser Lys Leu Glu Ser Gln Asn Lys Val Met 
            180                 185                 190         


Gln Glu Asn Ser Ser Ser Phe Ser Asp Leu Ser Glu Arg Arg Glu Arg 
        195                 200                 205             


Ser Ser Val Pro Ile Pro Ile Pro Ala Asp Thr Arg Asp Asn Glu Val 
    210                 215                 220                 


Asn His Ala Leu Glu Gln Gln Glu Ala Lys Arg Arg Glu Ala Glu Gln 
225                 230                 235                 240 


Ala Ala Ser Glu Ala Ala Gly Gly Asp Thr Thr Pro Gly Ser Ser Pro 
                245                 250                 255     


Ser Ser Leu Tyr Tyr Glu Glu Pro Leu Gly Gln Pro Pro Arg Phe Thr 
            260                 265                 270         


Gln Lys Leu Arg Ser Arg Glu Val Pro Glu Gly Thr Arg Val Gln Leu 
        275                 280                 285             


Asp Cys Ile Val Val Gly Ile Pro Pro Pro Gln Val Arg Trp Tyr Cys 
    290                 295                 300                 


Glu Gly Lys Glu Leu Glu Asn Ser Pro Asp Ile His Ile Val Gln Ala 
305                 310                 315                 320 


Gly Asn Leu His Ser Leu Thr Ile Ala Glu Ala Phe Glu Glu Asp Thr 
                325                 330                 335     


Gly Arg Tyr Ser Cys Phe Ala Ser Asn Ile Tyr Gly Thr Asp Ser Thr 
            340                 345                 350         


Ser Ala Glu Ile Tyr Ile Glu Gly Val Ser Ser Ser Asp Ser Glu Gly 
        355                 360                 365             


Asp Pro Asn Lys Glu Glu Met Asn Arg Ile Gln Lys Pro Asn Glu Val 
    370                 375                 380                 


Ser Ser Pro Pro Thr Thr Ser Ala Val Ile Pro Pro Ala Val Pro Gln 
385                 390                 395                 400 


Ala Gln His Leu Val Ala Gln Pro Arg Val Ala Thr Ile Gln Gln Cys 
                405                 410                 415     


Gln Ser Pro Thr Asn Tyr Leu Gln Gly Leu Asp Gly Lys Pro Ile Ile 
            420                 425                 430         


Ala Ala Pro Val Phe Thr Lys Met Leu Gln Asn Leu Ser Ala Ser Glu 
        435                 440                 445             


Gly Gln Leu Val Val Phe Glu Cys Arg Val Lys Gly Ala Pro Ser Pro 
    450                 455                 460                 


Lys Val Glu Trp Tyr Arg Glu Gly Thr Leu Ile Glu Asp Ser Pro Asp 
465                 470                 475                 480 


Phe Arg Ile Leu Gln Lys Arg Pro Val Cys Met Glu His Ile Glu Glu 
                485                 490                 495     


Ile Cys Thr Leu Val Ile Ala Glu Val Phe Ala Glu Asp Ser Gly Cys 
            500                 505                 510         


Phe Thr Cys Thr Ala Ser Asn Lys Tyr Gly Thr Val Ser Ser Ile Ala 
        515                 520                 525             


Gln Leu His Val Arg Gly Asn Glu Asp Leu Ser Asn Asn Gly Ser Leu 
    530                 535                 540                 


His Ser Ala Asn Ser Thr Thr Asn Leu Ala Ala Ile Glu Pro Gln Pro 
545                 550                 555                 560 


Ser Pro Pro His Ser Glu Pro Pro Ser Val Glu Gln Pro Pro Lys Pro 
                565                 570                 575     


Lys Leu Glu Gly Val Leu Val Asn His Asn Glu Pro Arg Ser Ser Ser 
            580                 585                 590         


Arg Ile Gly Leu Arg Val His Phe Asn Leu Pro Glu Asp Asp Lys Gly 
        595                 600                 605             


Ser Glu Ala Ser Ser Glu Ala Gly Val Val Thr Thr Arg Gln Thr Arg 
    610                 615                 620                 


Pro Asp Ser Phe Gln Glu Arg Phe Asn Gly Gln Ala Thr Lys Thr Pro 
625                 630                 635                 640 


Glu Pro Ser Ser Pro Val Lys Glu Pro Pro Pro Val Leu Ala Lys Pro 
                645                 650                 655     


Lys Leu Asp Ser Thr Gln Leu Gln Gln Leu His Asn Gln Val Leu Leu 
            660                 665                 670         


Glu Gln His Gln Leu Gln Asn Pro Pro Pro Ser Ser Pro Lys Glu Phe 
        675                 680                 685             


Pro Phe Ser Met Thr Val Leu Asn Ser Asn Ala Pro Pro Ala Val Thr 
    690                 695                 700                 


Thr Ser Ser Lys Gln Val Lys Ala Pro Ser Ser Gln Thr Phe Ser Leu 
705                 710                 715                 720 


Ala Arg Pro Lys Tyr Phe Phe Pro Ser Thr Asn Thr Thr Ala Ala Thr 
                725                 730                 735     


Val Ala Pro Ser Ser Ser Pro Val Phe Thr Leu Ser Ser Thr Pro Gln 
            740                 745                 750         


Thr Ile Gln Arg Thr Val Ser Lys Glu Ser Leu Leu Val Ser His Pro 
        755                 760                 765             


Ser Val Gln Thr Lys Ser Pro Gly Gly Leu Ser Ile Gln Asn Glu Pro 
    770                 775                 780                 


Leu Pro Pro Gly Pro Thr Glu Pro Thr Pro Pro Pro Phe Thr Phe Ser 
785                 790                 795                 800 


Ile Pro Ser Gly Asn Gln Phe Gln Pro Arg Cys Val Ser Pro Ile Pro 
                805                 810                 815     


Val Ser Pro Thr Ser Arg Ile Gln Asn Pro Val Ala Phe Leu Ser Ser 
            820                 825                 830         


Val Leu Pro Ser Leu Pro Ala Ile Pro Pro Thr Asn Ala Met Gly Leu 
        835                 840                 845             


Pro Arg Ser Ala Pro Ser Met Pro Ser Gln Gly Leu Ala Lys Lys Asn 
    850                 855                 860                 


Thr Lys Ser Pro Gln Pro Val Asn Asp Asp Asn Ile Arg Glu Thr Lys 
865                 870                 875                 880 


Asn Ala Val Ile Arg Asp Leu Gly Lys Lys Ile Thr Phe Ser Asp Val 
                885                 890                 895     


Arg Pro Asn Gln Gln Glu Tyr Lys Ile Ser Ser Phe Glu Gln Arg Leu 
            900                 905                 910         


Met Asn Glu Ile Glu Phe Arg Leu Glu Arg Thr Pro Val Asp Glu Ser 
        915                 920                 925             


Asp Asp Glu Ile Gln His Asp Glu Ile Pro Thr Gly Lys Cys Ile Ala 
    930                 935                 940                 


Pro Ile Phe Asp Lys Arg Leu Lys His Phe Arg Val Thr Glu Gly Ser 
945                 950                 955                 960 


Pro Val Thr Phe Thr Cys Lys Ile Val Gly Ile Pro Val Pro Lys Val 
                965                 970                 975     


Tyr Trp Phe Lys Asp Gly Lys Gln Ile Ser Lys Arg Asn Glu His Cys 
            980                 985                 990         


Lys Met Arg Arg Glu Gly Asp Gly  Thr Cys Ser Leu His  Ile Glu Ser 
        995                 1000                 1005             


Thr Thr  Ser Asp Asp Asp Gly  Asn Tyr Thr Ile Met  Ala Ala Asn 
    1010                 1015                 1020             


Pro Gln  Gly Arg Ile Ser Cys  Ser Gly His Leu Met  Val Gln Ser 
    1025                 1030                 1035             


Leu Pro  Ile Arg Ser Arg Leu  Thr Ser Ala Gly Gln  Ser His Arg 
    1040                 1045                 1050             


Gly Arg  Ser Arg Val Gln Glu  Arg Asp Lys Glu Pro  Leu Gln Glu 
    1055                 1060                 1065             


Arg Phe  Phe Arg Pro His Phe  Leu Gln Ala Pro Gly  Asp Met Val 
    1070                 1075                 1080             


Ala His  Glu Gly Arg Leu Cys  Arg Leu Asp Cys Lys  Val Ser Gly 
    1085                 1090                 1095             


Leu Pro  Pro Pro Glu Leu Thr  Trp Leu Leu Asn Gly  Gln Pro Val 
    1100                 1105                 1110             


Leu Pro  Asp Ala Ser His Lys  Met Leu Val Arg Glu  Thr Gly Val 
    1115                 1120                 1125             


His Ser  Leu Leu Ile Asp Pro  Leu Thr Gln Arg Asp  Ala Gly Thr 
    1130                 1135                 1140             


Tyr Lys  Cys Ile Ala Thr Asn  Lys Thr Gly Gln Asn  Ser Phe Ser 
    1145                 1150                 1155             


Leu Glu  Leu Ser Val Val Ala  Lys Glu Val Lys Lys  Ala Pro Val 
    1160                 1165                 1170             


Ile Leu  Glu Lys Leu Gln Asn  Cys Gly Val Pro Glu  Gly His Pro 
    1175                 1180                 1185             


Val Arg  Leu Glu Cys Arg Val  Ile Gly Met Pro Pro  Pro Val Phe 
    1190                 1195                 1200             


Tyr Trp  Lys Lys Asp Asn Glu  Thr Ile Pro Cys Thr  Arg Glu Arg 
    1205                 1210                 1215             


Ile Ser  Met His Gln Asp Thr  Thr Gly Tyr Ala Cys  Leu Leu Ile 
    1220                 1225                 1230             


Gln Pro  Ala Lys Lys Ser Asp  Ala Gly Trp Tyr Thr  Leu Ser Ala 
    1235                 1240                 1245             


Lys Asn  Glu Ala Gly Ile Val  Ser Cys Thr Ala Arg  Leu Asp Ile 
    1250                 1255                 1260             


Tyr Ala  Gln Trp His His Gln  Ile Pro Pro Pro Met  Ser Val Arg 
    1265                 1270                 1275             


Pro Ser  Gly Ser Arg Tyr Gly  Ser Leu Thr Ser Lys  Gly Leu Asp 
    1280                 1285                 1290             


Ile Phe  Ser Ala Phe Ser Ser  Met Glu Ser Thr Met  Val Tyr Ser 
    1295                 1300                 1305             


Cys Ser  Ser Arg Ser Val Val  Glu Ser Asp Glu Leu  
    1310                 1315                 1320 


<210> 8847
<211> 763
<212> PRT
<213> Homo sapiens

<400> 8847
Met Gln Asp Leu Gly Asp Lys Leu Arg Met Ile Val Met Gly His Arg 
1               5                   10                  15      


Arg Val His Ile Ser Arg Gln Leu Glu Val Glu Pro Glu Glu Pro Glu 
            20                  25                  30          


Ala Glu Asn Lys His Lys Pro Arg Arg Lys Ser Lys Arg Gly Lys Lys 
        35                  40                  45              


Glu Ala Glu Asp Glu Leu Ser Ala Arg His Pro Ala Glu Leu Ala Met 
    50                  55                  60                  


Glu Pro Thr Pro Glu Leu Pro Ala Glu Val Leu Met Val Glu Val Glu 
65                  70                  75                  80  


Asn Val Val His Glu Asp Phe Gln Val Thr Glu Glu Val Lys Ala Leu 
                85                  90                  95      


Thr Ala Glu Ile Val Lys Thr Ile Arg Asp Ile Ile Ala Leu Asn Pro 
            100                 105                 110         


Leu Tyr Arg Glu Ser Val Leu Gln Met Met Gln Ala Gly Gln Arg Val 
        115                 120                 125             


Val Asp Asn Pro Ile Tyr Leu Ser Asp Met Gly Ala Ala Leu Thr Gly 
    130                 135                 140                 


Ala Glu Ser His Glu Leu Gln Asp Val Leu Glu Glu Thr Asn Ile Pro 
145                 150                 155                 160 


Lys Arg Leu Tyr Lys Ala Leu Ser Leu Leu Lys Lys Glu Phe Glu Leu 
                165                 170                 175     


Ser Lys Leu Gln Gln Arg Leu Gly Arg Glu Val Glu Glu Lys Ile Lys 
            180                 185                 190         


Gln Thr His Arg Lys Tyr Leu Leu Gln Glu Gln Leu Lys Ile Ile Lys 
        195                 200                 205             


Lys Glu Leu Gly Leu Glu Lys Asp Asp Lys Asp Ala Ile Glu Glu Lys 
    210                 215                 220                 


Phe Arg Glu Arg Leu Lys Glu Leu Val Val Pro Lys His Val Met Asp 
225                 230                 235                 240 


Val Val Asp Glu Glu Leu Ser Lys Leu Gly Leu Leu Asp Asn His Ser 
                245                 250                 255     


Ser Glu Phe Asn Val Thr Arg Asn Tyr Leu Asp Trp Leu Thr Ser Ile 
            260                 265                 270         


Pro Trp Gly Lys Tyr Ser Asn Glu Asn Leu Asp Leu Ala Arg Ala Gln 
        275                 280                 285             


Ala Val Leu Glu Glu Asp His Tyr Gly Met Glu Asp Val Lys Lys Arg 
    290                 295                 300                 


Ile Leu Glu Phe Ile Ala Val Ser Gln Leu Arg Gly Ser Thr Gln Gly 
305                 310                 315                 320 


Lys Ile Leu Cys Phe Tyr Gly Pro Pro Gly Val Gly Lys Thr Ser Ile 
                325                 330                 335     


Ala Arg Ser Ile Ala Arg Ala Leu Asn Arg Glu Tyr Phe Arg Phe Ser 
            340                 345                 350         


Val Gly Gly Met Thr Asp Val Ala Glu Ile Lys Gly His Arg Arg Thr 
        355                 360                 365             


Tyr Val Gly Ala Met Pro Gly Lys Ile Ile Gln Cys Leu Lys Lys Thr 
    370                 375                 380                 


Lys Thr Glu Asn Pro Leu Ile Leu Ile Asp Glu Val Asp Lys Ile Gly 
385                 390                 395                 400 


Arg Gly Tyr Gln Gly Asp Pro Ser Ser Ala Leu Leu Glu Leu Leu Asp 
                405                 410                 415     


Pro Glu Gln Asn Ala Asn Phe Leu Asp His Tyr Leu Asp Val Pro Val 
            420                 425                 430         


Asp Leu Ser Lys Val Leu Phe Ile Cys Thr Ala Asn Val Thr Asp Thr 
        435                 440                 445             


Ile Pro Glu Pro Leu Arg Asp Arg Met Glu Met Ile Asn Val Ser Gly 
    450                 455                 460                 


Tyr Val Ala Gln Glu Lys Leu Ala Ile Ala Glu Arg Tyr Leu Val Pro 
465                 470                 475                 480 


Gln Ala Arg Ala Leu Cys Gly Leu Asp Glu Ser Lys Ala Lys Leu Ser 
                485                 490                 495     


Ser Asp Val Leu Thr Leu Leu Ile Lys Gln Tyr Cys Arg Glu Ser Gly 
            500                 505                 510         


Val Arg Asn Leu Gln Lys Gln Val Glu Lys Val Leu Arg Lys Ser Ala 
        515                 520                 525             


Tyr Lys Ile Val Ser Gly Glu Ala Glu Ser Val Glu Val Thr Pro Glu 
    530                 535                 540                 


Asn Leu Gln Asp Phe Val Gly Lys Pro Val Phe Thr Val Glu Arg Met 
545                 550                 555                 560 


Tyr Asp Val Thr Pro Pro Gly Val Val Met Gly Leu Ala Trp Thr Ala 
                565                 570                 575     


Met Gly Gly Ser Thr Leu Phe Val Glu Thr Ser Leu Arg Arg Pro Gln 
            580                 585                 590         


Asp Lys Asp Ala Lys Gly Asp Lys Asp Gly Ser Leu Glu Val Thr Gly 
        595                 600                 605             


Gln Leu Gly Glu Val Met Lys Glu Ser Ala Arg Ile Ala Tyr Thr Phe 
    610                 615                 620                 


Ala Arg Ala Phe Leu Met Gln His Ala Pro Ala Asn Asp Tyr Leu Val 
625                 630                 635                 640 


Thr Ser His Ile His Leu His Val Pro Glu Gly Ala Thr Pro Lys Asp 
                645                 650                 655     


Gly Pro Ser Ala Gly Cys Thr Ile Val Thr Ala Leu Leu Ser Leu Ala 
            660                 665                 670         


Met Gly Arg Pro Val Arg Gln Asn Leu Ala Met Thr Gly Glu Val Ser 
        675                 680                 685             


Leu Thr Gly Lys Ile Leu Pro Val Gly Gly Ile Lys Glu Lys Thr Ile 
    690                 695                 700                 


Ala Ala Lys Arg Ala Gly Val Thr Cys Ile Val Leu Pro Ala Glu Asn 
705                 710                 715                 720 


Lys Lys Asp Phe Tyr Asp Leu Ala Ala Phe Ile Thr Glu Gly Leu Glu 
                725                 730                 735     


Val His Phe Val Glu His Tyr Arg Glu Ile Phe Asp Ile Ala Phe Pro 
            740                 745                 750         


Asp Glu Gln Ala Glu Ala Leu Ala Val Glu Arg 
        755                 760             


<210> 8848
<211> 185
<212> PRT
<213> Homo sapiens

<400> 8848
Met Asn Asn Asn Gln Ile Val Ala Lys Asp Leu Gln Asp Glu Lys Ile 
1               5                   10                  15      


Leu Tyr Pro Glu Phe Asn Lys Leu Lys Glu Arg Asn Arg Glu Leu Lys 
            20                  25                  30          


Thr Leu Leu Ser Ile Gly Gly Trp Asn Phe Gly Thr Ser Arg Phe Thr 
        35                  40                  45              


Thr Met Leu Ser Thr Phe Ala Asn Arg Glu Lys Phe Ile Ala Ser Val 
    50                  55                  60                  


Ile Ser Leu Leu Arg Thr His Asp Phe Asp Gly Leu Asp Leu Phe Phe 
65                  70                  75                  80  


Leu Tyr Pro Gly Leu Arg Gly Ser Pro Met His Asp Arg Trp Thr Phe 
                85                  90                  95      


Leu Phe Leu Ile Glu Glu Leu Leu Phe Ala Phe Arg Lys Glu Ala Leu 
            100                 105                 110         


Leu Thr Met Arg Pro Arg Leu Leu Leu Ser Ala Ala Val Ser Gly Val 
        115                 120                 125             


Pro His Ile Val Gln Thr Ser Tyr Asp Val Arg Phe Leu Gly Arg Phe 
    130                 135                 140                 


Val Pro Leu Ser Gly Glu Arg Arg Ser Thr Gly Leu Ile Thr Ser Met 
145                 150                 155                 160 


Ser Arg Met Pro Thr Arg Gly Lys Ser Gly Leu Ala Met Thr Met Pro 
                165                 170                 175     


Ser Ala Ser Val Thr Arg His Gly Leu 
            180                 185 


<210> 8849
<211> 422
<212> PRT
<213> Homo sapiens

<400> 8849
Met Ser Gly Gly Thr Pro Tyr Ile Gly Ser Lys Ile Ser Leu Ile Ser 
1               5                   10                  15      


Lys Ala Glu Ile Arg Tyr Glu Gly Ile Leu Tyr Thr Ile Asp Thr Glu 
            20                  25                  30          


Asn Ser Thr Val Ala Leu Ala Lys Val Arg Ser Phe Gly Thr Glu Asp 
        35                  40                  45              


Arg Pro Thr Asp Arg Pro Ile Pro Pro Arg Asp Glu Val Phe Glu Tyr 
    50                  55                  60                  


Ile Ile Phe Arg Gly Ser Asp Ile Lys Asp Leu Thr Val Cys Glu Pro 
65                  70                  75                  80  


Pro Lys Pro Gln Cys Ser Leu Pro Gln Asp Pro Ala Ile Val Gln Ser 
                85                  90                  95      


Ser Leu Gly Ser Ser Thr Ser Ser Phe Gln Ser Met Gly Ser Tyr Gly 
            100                 105                 110         


Pro Phe Gly Arg Met Pro Thr Tyr Ser Gln Phe Ser Pro Ser Ser Leu 
        115                 120                 125             


Val Gly Gln Gln Phe Gly Ala Val Gly Val Gly Arg Ser Ser Pro Gln 
    130                 135                 140                 


Leu Asp Pro Leu Arg Lys Ser Pro Thr Met Glu Gln Ala Val Gln Thr 
145                 150                 155                 160 


Ala Ser Ala His Leu Pro Ala Pro Ala Ala Val Gly Arg Arg Ser Pro 
                165                 170                 175     


Val Ser Thr Arg Pro Leu Pro Ser Ala Ser Gln Lys Ala Gly Glu Asn 
            180                 185                 190         


Gln Glu His Arg Arg Ala Glu Val His Lys Val Ser Arg Pro Glu Asn 
        195                 200                 205             


Glu Gln Leu Arg Asn Asp Asn Lys Arg Gln Val Ala Pro Gly Ala Pro 
    210                 215                 220                 


Ser Ala Pro Arg Arg Gly Arg Gly Gly His Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Phe Gly Ile Arg Arg Asp Gly Pro Met Lys Phe Glu Lys Asp Phe Asp 
                245                 250                 255     


Phe Glu Ser Ala Asn Ala Gln Phe Asn Lys Glu Glu Ile Asp Arg Glu 
            260                 265                 270         


Phe His Asn Lys Leu Lys Leu Lys Glu Asp Lys Leu Glu Lys Gln Glu 
        275                 280                 285             


Lys Pro Val Asn Gly Glu Asp Lys Gly Asp Ser Gly Val Asp Thr Gln 
    290                 295                 300                 


Asn Ser Glu Gly Asn Ala Asp Glu Glu Asp Pro Leu Gly Pro Asn Cys 
305                 310                 315                 320 


Tyr Tyr Asp Lys Thr Lys Ser Phe Phe Asp Asn Ile Ser Cys Asp Asp 
                325                 330                 335     


Asn Arg Glu Arg Arg Pro Thr Trp Ala Glu Glu Arg Arg Leu Asn Ala 
            340                 345                 350         


Glu Thr Phe Gly Ile Pro Leu Arg Pro Asn Arg Gly Arg Gly Gly Tyr 
        355                 360                 365             


Arg Gly Arg Gly Gly Leu Gly Phe Arg Gly Gly Arg Gly Arg Gly Gly 
    370                 375                 380                 


Gly Arg Gly Gly Thr Phe Thr Ala Pro Arg Gly Phe Arg Gly Gly Phe 
385                 390                 395                 400 


Arg Gly Gly Arg Gly Gly Arg Glu Phe Ala Asp Phe Glu Tyr Arg Lys 
                405                 410                 415     


Thr Thr Ala Phe Gly Pro 
            420         


<210> 8850
<211> 421
<212> PRT
<213> Homo sapiens

<400> 8850
Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg 
        115                 120                 125             


Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser 
    130                 135                 140                 


Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala 
145                 150                 155                 160 


Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys 
                165                 170                 175     


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
            180                 185                 190         


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
        195                 200                 205             


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
    210                 215                 220                 


Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu 
225                 230                 235                 240 


Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu 
                245                 250                 255     


Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe 
            260                 265                 270         


Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His 
        275                 280                 285             


Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu 
    290                 295                 300                 


Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala 
305                 310                 315                 320 


Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile 
                325                 330                 335     


His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp 
            340                 345                 350         


Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr 
        355                 360                 365             


Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys 
    370                 375                 380                 


Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile 
385                 390                 395                 400 


Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile 
                405                 410                 415     


Thr Asn Ile Phe Ala 
            420     


<210> 8851
<211> 251
<212> PRT
<213> Homo sapiens

<400> 8851
Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr His Lys Pro 
1               5                   10                  15      


Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu Pro Ser Gln 
            20                  25                  30          


Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys Ile Leu His 
        35                  40                  45              


Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr Leu Gln Glu 
    50                  55                  60                  


Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu Asp Asn Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala Leu Glu Asn 
                85                  90                  95      


Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile Lys Gln Lys 
            100                 105                 110         


Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg Cys Thr Leu 
        115                 120                 125             


Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu Asn Val Glu 
    130                 135                 140                 


Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu Gln Arg Glu 
145                 150                 155                 160 


Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu Lys Leu Asp 
                165                 170                 175     


Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln Lys Thr Ala 
            180                 185                 190         


Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu Glu Glu His 
        195                 200                 205             


Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Leu Gln Thr Gly Leu 
    210                 215                 220                 


Glu Ile Ser Lys Ile Ile Met Ser Ser Val Ser Asn Leu Lys His Ser 
225                 230                 235                 240 


Lys Glu Lys Lys Lys Ser Ser Lys Val Cys Ile 
                245                 250     


<210> 8852
<211> 659
<212> PRT
<213> Homo sapiens

<400> 8852
Met Asp Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val 
1               5                   10                  15      


Ser Pro Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Glu Glu Leu 
            20                  25                  30          


Glu Ser Tyr Pro Leu Gly Ala Ile Val Arg Cys Asp Ala Val Met Pro 
        35                  40                  45              


Pro Gly Arg Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu 
    50                  55                  60                  


Arg Ala Gln Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala 
65                  70                  75                  80  


Glu Leu Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser 
                85                  90                  95      


Gly Arg Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu 
            100                 105                 110         


Leu Gln Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg 
        115                 120                 125             


Arg Pro Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly 
    130                 135                 140                 


Arg Gly Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln 
145                 150                 155                 160 


Arg Pro Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro 
                165                 170                 175     


Asp Leu Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg 
            180                 185                 190         


Glu Val Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val 
        195                 200                 205             


Ser Arg Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Arg 
    210                 215                 220                 


Glu Arg Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu 
225                 230                 235                 240 


Thr Leu Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu 
                245                 250                 255     


Gln Lys Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn 
            260                 265                 270         


Ile Ala Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly Pro 
        275                 280                 285             


Leu Gln Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser 
    290                 295                 300                 


Val Arg Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp 
305                 310                 315                 320 


Asn Val Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser 
                325                 330                 335     


Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr 
            340                 345                 350         


Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln 
        355                 360                 365             


Ser Arg Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg 
    370                 375                 380                 


Arg Arg Arg Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His Arg 
385                 390                 395                 400 


Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly 
                405                 410                 415     


Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu 
            420                 425                 430         


Leu Ser Val Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser Arg 
        435                 440                 445             


Lys Trp Trp Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val Pro 
    450                 455                 460                 


Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser Gln 
465                 470                 475                 480 


Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala Pro 
                485                 490                 495     


Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg Pro 
            500                 505                 510         


Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly Leu Asp Pro Ser Glu Lys 
        515                 520                 525             


Glu Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala Arg 
    530                 535                 540                 


Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro Arg 
545                 550                 555                 560 


Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val Arg 
                565                 570                 575     


Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala Leu 
            580                 585                 590         


Gly Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Lys Glu Glu Leu 
        595                 600                 605             


Arg Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val Thr 
    610                 615                 620                 


Val Gln Arg Ser Leu Leu Glu Asp Lys Glu Lys Val Ser Glu Leu Glu 
625                 630                 635                 640 


Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly Glu Val Glu Met 
                645                 650                 655     


Glu Val Ile 
            


<210> 8853
<211> 1233
<212> PRT
<213> Homo sapiens

<400> 8853
Met Asn Thr Lys Lys Arg Gly Ser Pro Ala Arg Thr His Ser Met Met 
1               5                   10                  15      


Ser Leu Ser Val Arg Pro Gln Arg Arg Leu Leu Ser Ala Arg Val Asn 
            20                  25                  30          


Arg Ser Gln Ser Phe Ala Gly Val Leu Gly Ser His Glu Arg Gly Pro 
        35                  40                  45              


Arg Ser Phe Pro Val Phe Ser Pro Pro Gly Pro Pro Arg Lys Pro Pro 
    50                  55                  60                  


Ala Leu Ser Arg Val Ser Arg Met Phe Ser Val Ala His Pro Ala Ala 
65                  70                  75                  80  


Lys Val Pro Gln Pro Glu Arg Leu Asp Leu Val Tyr Thr Ala Leu Lys 
                85                  90                  95      


Arg Gly Leu Thr Ala Tyr Leu Glu Val His Gln Gln Glu Gln Glu Lys 
            100                 105                 110         


Leu Gln Gly Gln Ile Arg Glu Ser Lys Arg Asn Ser Arg Leu Gly Phe 
        115                 120                 125             


Leu Tyr Asp Leu Asp Lys Gln Val Lys Ser Ile Glu Arg Phe Leu Arg 
    130                 135                 140                 


Arg Leu Glu Phe His Ala Ser Lys Ile Asp Glu Leu Tyr Glu Ala Tyr 
145                 150                 155                 160 


Cys Val Gln Arg Arg Leu Arg Asp Gly Ala Tyr Asn Met Val Arg Ala 
                165                 170                 175     


Tyr Thr Thr Gly Ser Pro Gly Ser Arg Glu Ala Arg Asp Ser Leu Ala 
            180                 185                 190         


Glu Ala Thr Arg Gly His Arg Glu Tyr Thr Glu Ser Met Cys Leu Leu 
        195                 200                 205             


Glu Ser Glu Leu Glu Ala Gln Leu Gly Glu Phe His Leu Arg Met Lys 
    210                 215                 220                 


Gly Leu Ala Gly Phe Ala Arg Leu Cys Val Gly Asp Gln Tyr Glu Ile 
225                 230                 235                 240 


Cys Met Lys Tyr Gly Arg Gln Arg Trp Lys Leu Arg Gly Arg Ile Glu 
                245                 250                 255     


Gly Ser Gly Lys Gln Val Trp Asp Ser Glu Glu Thr Ile Phe Leu Pro 
            260                 265                 270         


Leu Leu Thr Glu Phe Leu Ser Ile Lys Val Thr Glu Leu Lys Gly Leu 
        275                 280                 285             


Ala Asn His Val Val Val Gly Ser Val Ser Cys Glu Thr Lys Asp Leu 
    290                 295                 300                 


Phe Ala Ala Leu Pro Gln Val Val Ala Val Asp Ile Asn Asp Leu Gly 
305                 310                 315                 320 


Thr Ile Lys Leu Ser Leu Glu Val Thr Trp Ser Pro Phe Asp Lys Asp 
                325                 330                 335     


Asp Gln Pro Ser Ala Ala Ser Ser Val Asn Lys Ala Ser Thr Val Thr 
            340                 345                 350         


Lys Arg Phe Ser Thr Tyr Ser Gln Ser Pro Pro Asp Thr Pro Ser Leu 
        355                 360                 365             


Arg Glu Gln Ala Phe Tyr Asn Met Leu Arg Arg Gln Glu Glu Leu Glu 
    370                 375                 380                 


Asn Gly Thr Ala Trp Ser Leu Ser Ser Glu Ser Ser Asp Asp Ser Ser 
385                 390                 395                 400 


Ser Pro Gln Leu Ser Gly Thr Ala Arg His Ser Pro Ala Pro Arg Pro 
                405                 410                 415     


Leu Val Gln Gln Pro Glu Pro Leu Pro Ile Gln Val Ala Phe Arg Arg 
            420                 425                 430         


Pro Glu Thr Pro Ser Ser Gly Pro Leu Asp Glu Glu Gly Ala Val Ala 
        435                 440                 445             


Pro Val Leu Ala Asn Gly His Ala Pro Tyr Ser Arg Thr Leu Ser His 
    450                 455                 460                 


Ile Ser Glu Ala Ser Val Asp Ala Ala Leu Ala Glu Ala Ser Val Glu 
465                 470                 475                 480 


Ala Val Gly Pro Glu Ser Leu Ala Trp Gly Pro Ser Pro Pro Thr His 
                485                 490                 495     


Pro Ala Pro Thr His Gly Glu His Pro Ser Pro Val Pro Pro Ala Leu 
            500                 505                 510         


Asp Pro Gly His Ser Ala Thr Ser Ser Thr Leu Gly Thr Thr Gly Ser 
        515                 520                 525             


Val Pro Thr Ser Thr Asp Pro Ala Pro Ser Ala His Leu Asp Ser Val 
    530                 535                 540                 


His Lys Ser Thr Asp Ser Gly Pro Ser Glu Leu Pro Gly Pro Thr His 
545                 550                 555                 560 


Thr Thr Thr Gly Ser Thr Tyr Ser Ala Ile Thr Thr Thr His Ser Ala 
                565                 570                 575     


Pro Ser Pro Leu Thr His Thr Thr Thr Gly Ser Thr His Lys Pro Ile 
            580                 585                 590         


Ile Ser Thr Leu Thr Thr Thr Gly Pro Thr Leu Asn Ile Ile Gly Pro 
        595                 600                 605             


Val Gln Thr Thr Thr Ser Pro Thr His Thr Met Pro Ser Pro Thr His 
    610                 615                 620                 


Thr Thr Ala Ser Pro Thr His Thr Ser Thr Ser Pro Thr His Thr Pro 
625                 630                 635                 640 


Thr Ser Pro Thr His Lys Thr Ser Met Ser Pro Pro Thr Thr Thr Ser 
                645                 650                 655     


Pro Thr Pro Ser Gly Met Gly Leu Val Gln Thr Ala Thr Ser Pro Thr 
            660                 665                 670         


His Pro Thr Thr Ser Pro Thr His Pro Thr Thr Ser Pro Ile Leu Ile 
        675                 680                 685             


Asn Val Ser Pro Ser Thr Ser Leu Glu Leu Ala Thr Leu Ser Ser Pro 
    690                 695                 700                 


Ser Lys His Ser Asp Pro Thr Leu Pro Gly Thr Asp Ser Leu Pro Cys 
705                 710                 715                 720 


Ser Pro Pro Val Ser Asn Ser Tyr Thr Gln Ala Asp Pro Met Ala Pro 
                725                 730                 735     


Arg Thr Pro His Pro Ser Pro Ala His Ser Ser Arg Lys Pro Leu Thr 
            740                 745                 750         


Ser Pro Ala Pro Asp Pro Ser Glu Ser Thr Val Gln Ser Leu Ser Pro 
        755                 760                 765             


Thr Pro Ser Pro Pro Thr Pro Ala Pro Gln His Ser Asp Leu Cys Leu 
    770                 775                 780                 


Ala Met Ala Val Gln Thr Pro Val Pro Thr Ala Ala Gly Gly Ser Gly 
785                 790                 795                 800 


Asp Arg Ser Leu Glu Glu Ala Leu Gly Ala Leu Met Ala Ala Leu Asp 
                805                 810                 815     


Asp Tyr Arg Gly Gln Phe Pro Glu Leu Gln Gly Leu Glu Gln Glu Val 
            820                 825                 830         


Thr Arg Leu Glu Ser Leu Leu Met Gln Arg Gln Gly Leu Thr Arg Ser 
        835                 840                 845             


Arg Ala Ser Ser Leu Ser Ile Thr Val Glu His Ala Leu Glu Ser Phe 
    850                 855                 860                 


Ser Phe Leu Asn Glu Asp Glu Asp Glu Asp Asn Asp Val Pro Gly Asp 
865                 870                 875                 880 


Arg Pro Pro Ser Ser Pro Glu Ala Gly Ala Glu Asp Ser Ile Asp Ser 
                885                 890                 895     


Pro Ser Ala Arg Pro Leu Ser Thr Gly Cys Pro Ala Leu Asp Ala Ala 
            900                 905                 910         


Leu Val Arg His Leu Tyr His Cys Ser Arg Leu Leu Leu Lys Leu Gly 
        915                 920                 925             


Thr Phe Gly Pro Leu Arg Cys Gln Glu Ala Trp Ala Leu Glu Arg Leu 
    930                 935                 940                 


Leu Arg Glu Ala Arg Val Leu Glu Ala Val Cys Glu Phe Ser Arg Arg 
945                 950                 955                 960 


Trp Glu Ile Pro Ala Ser Ser Ala Gln Glu Val Val Gln Phe Ser Ala 
                965                 970                 975     


Ser Arg Pro Gly Phe Leu Thr Phe Trp Asp Gln Cys Thr Glu Arg Leu 
            980                 985                 990         


Ser Cys Phe Leu Cys Pro Val Glu  Arg Val Leu Leu Thr  Phe Cys Asn 
        995                 1000                 1005             


Gln Tyr  Gly Ala Arg Leu Ser  Leu Arg Gln Pro Gly  Leu Ala Glu 
    1010                 1015                 1020             


Ala Val  Cys Val Lys Phe Leu  Glu Asp Ala Leu Gly  Gln Lys Leu 
    1025                 1030                 1035             


Pro Arg  Arg Pro Gln Pro Gly  Pro Gly Glu Gln Leu  Thr Val Phe 
    1040                 1045                 1050             


Gln Phe  Trp Ser Phe Val Glu  Thr Leu Asp Ser Pro  Thr Met Glu 
    1055                 1060                 1065             


Ala Tyr  Val Thr Glu Thr Ala  Glu Glu Val Leu Leu  Val Arg Asn 
    1070                 1075                 1080             


Leu Asn  Ser Asp Asp Gln Ala  Val Val Leu Lys Ala  Leu Arg Leu 
    1085                 1090                 1095             


Ala Pro  Glu Gly Arg Leu Arg  Arg Asp Gly Leu Arg  Ala Leu Ser 
    1100                 1105                 1110             


Ser Leu  Leu Val His Gly Asn  Asn Lys Val Met Ala  Ala Val Ser 
    1115                 1120                 1125             


Thr Gln  Leu Arg Ser Leu Ser  Leu Gly Pro Thr Phe  Arg Glu Arg 
    1130                 1135                 1140             


Ala Leu  Leu Cys Phe Leu Asp  Gln Leu Glu Asp Glu  Asp Val Gln 
    1145                 1150                 1155             


Thr Arg  Val Ala Gly Cys Leu  Ala Leu Gly Cys Ile  Lys Ala Pro 
    1160                 1165                 1170             


Glu Gly  Ile Glu Pro Leu Val  Tyr Leu Cys Gln Thr  Asp Thr Glu 
    1175                 1180                 1185             


Ala Val  Arg Glu Ala Ala Arg  Gln Ser Leu Gln Gln  Cys Gly Glu 
    1190                 1195                 1200             


Glu Gly  Gln Ser Ala His Arg  Arg Leu Glu Glu Ser  Leu Asp Ala 
    1205                 1210                 1215             


Leu Pro  Arg Ile Phe Gly Pro  Gly Ser Met Ala Ser  Thr Ala Phe 
    1220                 1225                 1230             


<210> 8854
<211> 475
<212> PRT
<213> Homo sapiens

<400> 8854
Met Asp Gln Met Val Gln His Pro Ala Ala Lys Met Ile Val Met Ala 
1               5                   10                  15      


Ser His Met Gln Glu Gln Glu Val Gly Asp Gly Thr Asn Phe Val Leu 
            20                  25                  30          


Val Phe Ala Gly Ala Leu Leu Glu Leu Ala Glu Glu Leu Leu Arg Ile 
        35                  40                  45              


Gly Leu Ser Val Ser Glu Val Ile Glu Gly Tyr Glu Ile Ala Cys Arg 
    50                  55                  60                  


Lys Ala His Glu Ile Leu Pro Asn Leu Val Cys Cys Ser Ala Lys Asn 
65                  70                  75                  80  


Leu Arg Asp Ile Asp Glu Val Ser Ser Leu Leu Arg Thr Ser Ile Met 
                85                  90                  95      


Ser Lys Gln Tyr Gly Asn Glu Val Phe Leu Ala Lys Leu Ile Ala Gln 
            100                 105                 110         


Ala Cys Val Ser Ile Phe Pro Asp Ser Gly His Phe Asn Val Asp Asn 
        115                 120                 125             


Ile Arg Val Cys Lys Ile Leu Gly Ser Gly Ile Ser Ser Ser Ser Val 
    130                 135                 140                 


Leu His Gly Met Val Phe Lys Lys Glu Thr Glu Gly Asp Val Thr Ser 
145                 150                 155                 160 


Val Lys Asp Ala Lys Ile Ala Val Tyr Ser Cys Pro Phe Asp Gly Met 
                165                 170                 175     


Ile Thr Glu Thr Lys Gly Thr Val Leu Ile Lys Thr Ala Glu Glu Leu 
            180                 185                 190         


Met Asn Phe Ser Lys Gly Glu Glu Asn Leu Met Asp Ala Gln Val Lys 
        195                 200                 205             


Ala Ile Ala Asp Thr Gly Ala Asn Val Val Val Thr Gly Gly Lys Val 
    210                 215                 220                 


Ala Asp Met Ala Leu His Tyr Ala Asn Lys Tyr Asn Ile Met Leu Val 
225                 230                 235                 240 


Arg Leu Asn Ser Lys Trp Asp Leu Arg Arg Leu Cys Lys Thr Val Gly 
                245                 250                 255     


Ala Thr Ala Leu Pro Arg Leu Thr Pro Pro Val Leu Glu Glu Met Gly 
            260                 265                 270         


His Cys Asp Ser Val Tyr Leu Ser Glu Val Gly Asp Thr Gln Val Val 
        275                 280                 285             


Val Phe Lys His Glu Lys Glu Asp Gly Ala Ile Ser Thr Ile Val Leu 
    290                 295                 300                 


Arg Gly Ser Thr Asp Asn Leu Met Asp Asp Ile Glu Arg Ala Val Asp 
305                 310                 315                 320 


Asp Gly Val Asn Thr Phe Lys Val Leu Thr Arg Asp Lys Arg Leu Val 
                325                 330                 335     


Pro Gly Gly Gly Ala Thr Glu Ile Glu Leu Ala Lys Gln Ile Thr Ser 
            340                 345                 350         


Tyr Gly Glu Thr Cys Pro Gly Leu Glu Gln Tyr Ala Ile Lys Lys Phe 
        355                 360                 365             


Ala Glu Ala Phe Glu Ala Ile Pro Arg Ala Leu Ala Glu Asn Ser Gly 
    370                 375                 380                 


Val Lys Ala Asn Glu Val Ile Ser Lys Leu Tyr Ala Val His Gln Glu 
385                 390                 395                 400 


Gly Asn Lys Asn Val Gly Leu Asp Ile Glu Ala Glu Val Pro Ala Val 
                405                 410                 415     


Lys Asp Met Leu Glu Ala Gly Ile Leu Asp Thr Tyr Leu Gly Lys Tyr 
            420                 425                 430         


Trp Ala Ile Lys Leu Ala Thr Asn Ala Ala Val Thr Val Leu Arg Val 
        435                 440                 445             


Asp Gln Ile Ile Met Ala Lys Pro Ala Gly Gly Pro Lys Pro Pro Ser 
    450                 455                 460                 


Gly Lys Lys Asp Trp Asp Asp Asp Gln Asn Asp 
465                 470                 475 


<210> 8855
<211> 541
<212> PRT
<213> Homo sapiens

<400> 8855
Met Arg Ala Leu Leu His Lys Pro Glu Met Ile Lys Gln Ile Leu Pro 
1               5                   10                  15      


Glu His Ser Val Leu Gln Asn Ile Asn Phe Val Glu Ala Phe Gln Asp 
            20                  25                  30          


Glu Leu Leu Val Thr Glu Val Tyr Asp Leu Pro Gln Arg Pro Asn Asp 
        35                  40                  45              


Val Gln Leu Phe Tyr Gly Ser Met Cys Lys Ile Ile Leu Ser Val Ile 
    50                  55                  60                  


Gly Glu Phe Arg Asp Cys Ile Ser Ser Arg Glu Phe Leu Gln Pro Ser 
65                  70                  75                  80  


Ser Lys Ala Ser Leu Glu Ser Thr Ser Asp Leu Gly Ala Ser Gly Lys 
                85                  90                  95      


His Gly Gly Asn Val Ser Leu Asp Val Leu Pro Val Lys Gly Pro Gln 
            100                 105                 110         


Gly Ser Pro Leu Leu Ser Arg Ala Ala Arg Pro Pro Leu Asp Gln Leu 
        115                 120                 125             


Ala Ser Glu Glu Pro Trp Thr Val Leu Pro Glu His Leu Ile Leu Val 
    130                 135                 140                 


Ala Pro Ser Pro Cys Asp Met Ala Lys Thr Gly Arg Phe Gln Ile Val 
145                 150                 155                 160 


Asn Asn Ser Val Arg Leu Leu Arg Phe Glu Leu Cys Trp Pro Ala His 
                165                 170                 175     


Cys Leu Thr Val Thr Pro Gln His Gly Cys Val Ala Pro Glu Ser Lys 
            180                 185                 190         


Leu Gln Ile Leu Val Ser Pro Asn Ser Ser Leu Ser Thr Lys Gln Ser 
        195                 200                 205             


Met Phe Pro Trp Ser Gly Leu Ile Tyr Ile His Cys Asp Asp Gly Gln 
    210                 215                 220                 


Lys Lys Ile Val Lys Val Gln Ile Arg Glu Asp Leu Thr Gln Val Glu 
225                 230                 235                 240 


Leu Leu Thr Arg Leu Thr Ser Lys Pro Phe Gly Ile Leu Ser Pro Val 
                245                 250                 255     


Ser Glu Pro Ser Val Ser His Leu Val Lys Pro Met Thr Lys Pro Pro 
            260                 265                 270         


Ser Thr Lys Val Glu Ile Arg Asn Lys Ser Ile Thr Phe Pro Thr Thr 
        275                 280                 285             


Glu Pro Gly Glu Thr Ser Glu Ser Cys Leu Glu Leu Glu Asn His Gly 
    290                 295                 300                 


Thr Thr Asp Val Lys Trp His Leu Ser Ser Leu Ala Pro Pro Tyr Val 
305                 310                 315                 320 


Lys Gly Val Asp Glu Ser Gly Asp Val Phe Arg Ala Thr Tyr Ala Ala 
                325                 330                 335     


Phe Arg Cys Ser Pro Ile Ser Gly Leu Leu Glu Ser His Gly Ile Gln 
            340                 345                 350         


Lys Val Ser Ile Thr Phe Leu Pro Arg Gly Arg Gly Asp Tyr Ala Gln 
        355                 360                 365             


Phe Trp Asp Val Glu Cys His Pro Leu Lys Glu Pro His Met Lys His 
    370                 375                 380                 


Thr Leu Arg Phe Gln Leu Ser Gly Gln Ser Ile Glu Ala Glu Asn Glu 
385                 390                 395                 400 


Pro Glu Asn Ala Cys Leu Ser Thr Asp Ser Leu Ile Lys Ile Asp His 
                405                 410                 415     


Leu Val Lys Pro Arg Arg Gln Ala Val Ser Glu Ala Ser Ala Arg Ile 
            420                 425                 430         


Pro Glu Gln Leu Asp Val Thr Ala Arg Gly Val Tyr Ala Pro Glu Asp 
        435                 440                 445             


Val Tyr Arg Phe Arg Pro Thr Ser Val Gly Glu Ser Arg Thr Leu Lys 
    450                 455                 460                 


Val Asn Leu Arg Asn Asn Ser Phe Ile Thr His Ser Leu Lys Phe Leu 
465                 470                 475                 480 


Ser Pro Arg Glu Pro Phe Tyr Val Lys His Ser Lys Tyr Ser Leu Arg 
                485                 490                 495     


Ala Gln His Tyr Ile Asn Met Pro Val Gln Phe Lys Pro Lys Ser Ala 
            500                 505                 510         


Gly Lys Phe Glu Ala Leu Leu Val Ile Gln Thr Asp Glu Gly Lys Ser 
        515                 520                 525             


Ile Ala Ile Arg Leu Ile Gly Glu Ala Leu Gly Lys Asn 
    530                 535                 540     


<210> 8856
<211> 578
<212> PRT
<213> Homo sapiens

<400> 8856
Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Met Glu Asp 
    50                  55                  60                  


Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His Asp Arg Ser 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gln Pro Arg 
                85                  90                  95      


Arg Arg Val Gln Arg Lys Arg Ala Asn Arg Asp Gln Asp Ser Ser Asp 
            100                 105                 110         


Asp Glu Arg Ala Leu Glu Asp Trp Val Ser Ser Glu Thr Ser Ala Leu 
        115                 120                 125             


Pro Arg Pro Arg Trp Gln Ala Leu Pro Ala Leu Arg Glu Arg Glu Leu 
    130                 135                 140                 


Gly Ser Ser Ala Arg Phe Val Tyr Glu Ala Cys Gly Ala Arg Val Phe 
145                 150                 155                 160 


Val Gln Arg Phe Arg Leu Gln His Gly Leu Glu Gly His Thr Gly Cys 
                165                 170                 175     


Val Asn Thr Leu His Phe Asn Gln Arg Gly Thr Trp Leu Ala Ser Gly 
            180                 185                 190         


Ser Asp Asp Leu Lys Val Val Val Trp Asp Trp Val Arg Arg Gln Pro 
        195                 200                 205             


Val Leu Asp Phe Glu Ser Gly His Lys Ser Asn Val Phe Gln Ala Lys 
    210                 215                 220                 


Phe Leu Pro Asn Ser Gly Asp Ser Thr Leu Ala Met Cys Ala Arg Asp 
225                 230                 235                 240 


Gly Gln Val Arg Val Ala Glu Leu Ser Ala Thr Gln Cys Cys Lys Asn 
                245                 250                 255     


Thr Lys Arg Val Ala Gln His Lys Gly Ala Ser His Lys Leu Ala Leu 
            260                 265                 270         


Glu Pro Asp Ser Pro Cys Thr Phe Leu Ser Ala Gly Glu Asp Ala Val 
        275                 280                 285             


Val Phe Thr Ile Asp Leu Arg Gln Asp Arg Pro Ala Ser Lys Leu Val 
    290                 295                 300                 


Val Thr Lys Glu Lys Glu Lys Lys Val Gly Leu Tyr Thr Ile Tyr Val 
305                 310                 315                 320 


Asn Pro Ala Asn Thr His Gln Phe Ala Val Gly Gly Arg Asp Gln Phe 
                325                 330                 335     


Val Arg Ile Tyr Asp Gln Arg Lys Ile Asp Glu Asn Glu Asn Asn Gly 
            340                 345                 350         


Val Leu Lys Lys Phe Cys Pro His His Leu Val Asn Ser Glu Ser Lys 
        355                 360                 365             


Ala Asn Ile Thr Cys Leu Val Tyr Ser His Asp Gly Thr Glu Leu Leu 
    370                 375                 380                 


Ala Ser Tyr Asn Asp Glu Asp Ile Tyr Leu Phe Asn Ser Ser His Ser 
385                 390                 395                 400 


Asp Gly Ala Gln Tyr Val Lys Arg Tyr Lys Gly His Arg Asn Asn Ala 
                405                 410                 415     


Thr Val Lys Gly Val Asn Phe Tyr Gly Pro Lys Ser Glu Phe Val Val 
            420                 425                 430         


Ser Gly Ser Asp Cys Gly His Ile Phe Leu Trp Glu Lys Ser Ser Cys 
        435                 440                 445             


Gln Ile Ile Gln Phe Met Glu Gly Asp Lys Gly Gly Val Val Asn Cys 
    450                 455                 460                 


Leu Glu Pro His Pro His Leu Pro Val Leu Ala Thr Ser Gly Leu Asp 
465                 470                 475                 480 


His Asp Val Lys Ile Trp Ala Pro Thr Ala Glu Ala Ser Thr Glu Leu 
                485                 490                 495     


Thr Gly Leu Lys Asp Val Ile Lys Lys Asn Lys Arg Glu Arg Asp Glu 
            500                 505                 510         


Asp Ser Leu His Gln Thr Asp Leu Phe Asp Ser His Met Leu Trp Phe 
        515                 520                 525             


Leu Met His His Leu Arg Gln Arg Arg His His Arg Arg Trp Arg Glu 
    530                 535                 540                 


Pro Gly Val Gly Ala Thr Asp Ala Asp Ser Asp Glu Ser Pro Ser Ser 
545                 550                 555                 560 


Ser Asp Thr Ser Asp Glu Glu Glu Gly Pro Asp Arg Val Gln Cys Met 
                565                 570                 575     


Pro Ser 
        


<210> 8857
<211> 141
<212> PRT
<213> Homo sapiens

<400> 8857
Met Gly Gly Lys Pro Arg His Ser Leu Tyr Phe Ile Gly Tyr Gln Asp 
1               5                   10                  15      


Asp Phe Leu Leu Tyr Leu Asp Pro His Tyr Cys Gln Pro Thr Val Asp 
            20                  25                  30          


Val Ser Gln Ala Asp Phe Pro Leu Glu Ser Phe His Cys Thr Ser Pro 
        35                  40                  45              


Arg Lys Met Ala Phe Ala Lys Met Asp Pro Ser Cys Thr Val Gly Phe 
    50                  55                  60                  


Tyr Ala Gly Asp Arg Lys Glu Phe Glu Thr Leu Cys Ser Glu Leu Thr 
65                  70                  75                  80  


Arg Val Leu Ser Ser Ser Ser Ala Thr Glu Arg Tyr Pro Met Phe Thr 
                85                  90                  95      


Leu Ala Glu Gly His Ala Gln Asp His Ser Leu Asp Asp Leu Cys Ser 
            100                 105                 110         


Gln Leu Ala Gln Pro Thr Leu Arg Leu Pro Arg Thr Gly Arg Leu Leu 
        115                 120                 125             


Arg Ala Lys Arg Pro Ser Ser Glu Asp Phe Val Phe Leu 
    130                 135                 140     


<210> 8858
<211> 189
<212> PRT
<213> Homo sapiens

<400> 8858
Met Val Leu Leu His Val Lys Arg Gly Asp Glu Ser Gln Phe Leu Leu 
1               5                   10                  15      


Gln Ala Pro Gly Ser Thr Glu Leu Glu Glu Leu Thr Val Gln Val Ala 
            20                  25                  30          


Arg Val Tyr Asn Gly Arg Leu Lys Val Gln Arg Leu Cys Ser Ala Pro 
        35                  40                  45              


Asn Glu Lys Met Lys Gln Val Leu Lys Lys Thr Ile Glu Glu Ala Lys 
    50                  55                  60                  


Ala Ile Ile Ser Lys Lys Gln Val Glu Ala Gly Val Cys Val Thr Met 
65                  70                  75                  80  


Glu Met Val Lys Asp Ala Leu Asp Gln Leu Arg Gly Ala Val Met Ile 
                85                  90                  95      


Val Tyr Pro Met Gly Leu Pro Pro Tyr Asp Pro Ile Arg Met Glu Phe 
            100                 105                 110         


Glu Asn Lys Glu Asp Leu Ser Gly Thr Gln Ala Gly Leu Asn Val Ile 
        115                 120                 125             


Lys Glu Ala Glu Ala Gln Leu Trp Trp Ala Ala Lys Glu Leu Arg Arg 
    130                 135                 140                 


Thr Lys Lys Leu Ser Asp Tyr Val Gly Lys Asn Glu Lys Thr Lys Ile 
145                 150                 155                 160 


Ile Ala Lys Ile Gln Gln Val Ser Thr Phe Cys Phe Asn Val Ser Val 
                165                 170                 175     


Val Phe Val Ile Ser Leu Gln Thr Asp Lys Asn Val Gln 
            180                 185                 


<210> 8859
<211> 676
<212> PRT
<213> Homo sapiens

<400> 8859
Met Ala Ala Ile Gln His Gly His Glu Ala Val Val Arg Leu Leu Met 
1               5                   10                  15      


Glu Trp Gly Ala Asp Pro Asn His Ala Ala Arg Thr Val Gly Trp Ser 
            20                  25                  30          


Pro Leu Met Leu Ala Ala Leu Thr Gly Arg Leu Gly Val Ala Gln Gln 
        35                  40                  45              


Leu Val Glu Lys Gly Ala Asn Pro Asp His Leu Ser Val Leu Glu Lys 
    50                  55                  60                  


Thr Ala Phe Glu Val Ala Leu Asp Cys Lys His Arg Asp Leu Val Asp 
65                  70                  75                  80  


Tyr Leu Asp Pro Leu Thr Thr Val Arg Pro Lys Thr Asp Glu Glu Lys 
                85                  90                  95      


Arg Arg Pro Asp Ile Phe His Ala Leu Lys Met Gly Asn Phe Gln Leu 
            100                 105                 110         


Val Lys Glu Ile Ala Asp Glu Asp Pro Ser His Val Asn Leu Val Asn 
        115                 120                 125             


Gly Asp Gly Ala Thr Pro Leu Met Leu Ala Ala Val Thr Gly Gln Leu 
    130                 135                 140                 


Ala Leu Val Gln Leu Leu Val Glu Arg His Ala Asp Val Asp Lys Gln 
145                 150                 155                 160 


Asp Ser Val His Gly Trp Thr Ala Leu Met Gln Ala Thr Tyr His Gly 
                165                 170                 175     


Asn Lys Glu Ile Val Lys Tyr Leu Leu Asn Gln Gly Ala Asp Val Thr 
            180                 185                 190         


Leu Arg Ala Lys Asn Gly Tyr Thr Ala Phe Asp Leu Val Met Leu Leu 
        195                 200                 205             


Asn Asp Pro Asp Thr Glu Leu Val Arg Leu Leu Ala Ser Val Cys Met 
    210                 215                 220                 


Gln Val Asn Lys Asp Lys Gly Arg Pro Ser His Gln Pro Pro Leu Pro 
225                 230                 235                 240 


His Ser Lys Val Arg Gln Pro Trp Ser Ile Pro Val Leu Pro Asp Asp 
                245                 250                 255     


Lys Gly Gly Leu Lys Ser Trp Trp Asn Arg Met Ser Asn Arg Phe Arg 
            260                 265                 270         


Lys Leu Lys Leu Met Gln Thr Leu Pro Arg Gly Leu Ser Ser Asn Gln 
        275                 280                 285             


Pro Leu Pro Phe Ser Asp Glu Pro Glu Pro Ala Leu Asp Ser Thr Met 
    290                 295                 300                 


Arg Ala Ala Pro Gln Asp Lys Thr Ser Arg Ser Ala Leu Pro Asp Ala 
305                 310                 315                 320 


Ala Pro Val Thr Lys Asp Asn Gly Pro Gly Ser Thr Arg Gly Glu Lys 
                325                 330                 335     


Glu Asp Thr Leu Leu Thr Thr Met Leu Arg Asn Gly Ala Pro Leu Thr 
            340                 345                 350         


Arg Leu Pro Ser Asp Lys Leu Lys Ala Val Ile Pro Pro Phe Leu Pro 
        355                 360                 365             


Pro Ser Ser Phe Glu Leu Trp Ser Ser Asp Arg Ser Arg Thr Arg His 
    370                 375                 380                 


Asn Gly Lys Ala Asp Pro Met Lys Thr Ala Leu Pro Gln Arg Ala Ser 
385                 390                 395                 400 


Arg Gly His Pro Val Gly Gly Gly Gly Thr Asp Thr Thr Pro Val Arg 
                405                 410                 415     


Pro Val Lys Phe Pro Ser Leu Pro Arg Ser Pro Ala Ser Ser Ala Asn 
            420                 425                 430         


Ser Gly Asn Phe Asn His Ser Pro His Ser Ser Gly Gly Ser Ser Gly 
        435                 440                 445             


Val Gly Val Ser Arg His Gly Gly Glu Leu Leu Asn Arg Ser Gly Gly 
    450                 455                 460                 


Ser Ile Asp Asn Val Leu Ser Gln Ile Ala Ala Gln Arg Lys Lys Ala 
465                 470                 475                 480 


Ala Gly Leu Leu Glu Gln Lys Pro Ser His Arg Ser Ser Pro Val Gly 
                485                 490                 495     


Pro Ala Pro Gly Ser Ser Pro Ser Glu Leu Pro Ala Ser Pro Ala Gly 
            500                 505                 510         


Gly Ser Ala Pro Val Gly Lys Lys Leu Glu Thr Ser Lys Arg Pro Pro 
        515                 520                 525             


Ser Gly Thr Ser Thr Thr Ser Lys Ser Thr Ser Pro Thr Leu Thr Pro 
    530                 535                 540                 


Ser Pro Ser Pro Lys Gly His Thr Ala Glu Ser Ser Val Ser Ser Ser 
545                 550                 555                 560 


Ser Ser His Arg Gln Ser Lys Ser Ser Gly Gly Ser Ser Ser Gly Thr 
                565                 570                 575     


Ile Thr Asp Glu Asp Glu Leu Thr Gly Ile Leu Lys Lys Leu Ser Leu 
            580                 585                 590         


Glu Lys Tyr Gln Pro Ile Phe Glu Glu Gln Glu Val Asp Met Glu Ala 
        595                 600                 605             


Phe Leu Thr Leu Thr Asp Gly Asp Leu Lys Glu Leu Gly Ile Lys Thr 
    610                 615                 620                 


Asp Gly Ser Arg Gln Gln Ile Leu Ala Ala Ile Ser Glu Leu Asn Ala 
625                 630                 635                 640 


Gly Lys Gly Arg Glu Arg Gln Ile Leu Gln Glu Thr Ile His Asn Phe 
                645                 650                 655     


His Ser Ser Phe Glu Ser Ser Ala Ser Asn Thr Arg Ala Pro Gly Asn 
            660                 665                 670         


Ser Pro Cys Ala 
        675     


<210> 8860
<211> 772
<212> PRT
<213> Homo sapiens

<400> 8860
Met Arg His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys Arg Leu 
1               5                   10                  15      


Gln Phe Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln His His 
            20                  25                  30          


Lys Thr Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro Gly Thr 
        35                  40                  45              


Lys Val Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val Pro Val 
    50                  55                  60                  


Ser Ser Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala Pro Leu 
65                  70                  75                  80  


Thr Ser Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro Val Gln 
                85                  90                  95      


Arg Ser Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met Gly Arg 
            100                 105                 110         


Gln Thr Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro Asn His 
        115                 120                 125             


Phe Pro Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr Cys Cys 
    130                 135                 140                 


Ser Arg Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro Arg Lys 
145                 150                 155                 160 


Ser Pro Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly Ile Lys 
                165                 170                 175     


Leu Ala Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp Ala Met 
            180                 185                 190         


Ala Lys His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser Ile Leu 
        195                 200                 205             


Pro Arg Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln Thr Arg 
    210                 215                 220                 


Asp Arg Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro Pro Ser 
225                 230                 235                 240 


Phe Pro Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala Thr Pro 
                245                 250                 255     


Ala Glu Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu Pro Ser 
            260                 265                 270         


Pro Ala Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro Gln Ala 
        275                 280                 285             


Leu Ala Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu Asn Val 
    290                 295                 300                 


Asp Asp Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu Leu Ala 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln Leu Ser 
                325                 330                 335     


Val Lys Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn Thr Glu 
            340                 345                 350         


Gln Ala Ala Glu His Phe Arg Asn Pro Gln Arg Arg Ile Arg Arg Trp 
        355                 360                 365             


Leu Arg Arg Phe Gln Ala Ser Gln Gly Glu Asn Leu Glu Gly Lys Tyr 
    370                 375                 380                 


Leu Ser Phe Glu Ala Glu Glu Lys Leu Ala Glu Trp Val Leu Thr Gln 
385                 390                 395                 400 


Arg Glu Gln Gln Leu Pro Val Asn Glu Glu Thr Leu Phe Gln Lys Ala 
                405                 410                 415     


Thr Lys Ile Gly Arg Ser Leu Glu Gly Gly Phe Lys Ile Ser Tyr Glu 
            420                 425                 430         


Trp Ala Val Arg Phe Met Leu Arg His His Leu Thr Pro His Ala Arg 
        435                 440                 445             


Arg Ala Val Ala His Thr Leu Pro Lys Asp Val Ala Glu Asn Ala Gly 
    450                 455                 460                 


Leu Phe Ile Asp Phe Val Gln Arg Gln Ile His Asn Gln Asp Leu Pro 
465                 470                 475                 480 


Leu Ser Met Ile Val Ala Ile Asp Glu Ile Ser Leu Phe Leu Asp Thr 
                485                 490                 495     


Glu Val Leu Ser Ser Asp Asp Arg Lys Glu Asn Ala Leu Gln Thr Val 
            500                 505                 510         


Gly Thr Gly Glu Pro Trp Cys Asp Val Val Leu Ala Ile Leu Ala Asp 
        515                 520                 525             


Gly Thr Val Leu Pro Thr Leu Val Phe Tyr Arg Gly Gln Met Asp Gln 
    530                 535                 540                 


Pro Ala Asn Met Pro Asp Ser Ile Leu Leu Glu Ala Lys Glu Ser Gly 
545                 550                 555                 560 


Tyr Ser Asp Asp Glu Ile Met Glu Leu Trp Ser Thr Arg Val Trp Gln 
                565                 570                 575     


Lys His Thr Ala Cys Gln Arg Ser Lys Gly Met Leu Val Met Asp Cys 
            580                 585                 590         


His Arg Thr His Leu Ser Glu Glu Val Leu Ala Met Leu Ser Ala Ser 
        595                 600                 605             


Ser Thr Leu Pro Ala Val Val Pro Ala Gly Cys Ser Ser Lys Ile Gln 
    610                 615                 620                 


Pro Leu Asp Val Cys Ile Lys Arg Thr Val Lys Asn Phe Leu His Lys 
625                 630                 635                 640 


Lys Trp Lys Glu Gln Ala Arg Glu Met Ala Asp Thr Ala Cys Asp Ser 
                645                 650                 655     


Asp Val Leu Leu Gln Leu Val Leu Val Trp Leu Gly Glu Val Leu Gly 
            660                 665                 670         


Val Ile Gly Asp Cys Pro Glu Leu Val Gln Arg Ser Phe Leu Val Ala 
        675                 680                 685             


Ser Val Leu Pro Gly Pro Asp Gly Asn Ile Asn Ser Pro Thr Arg Asn 
    690                 695                 700                 


Ala Asp Met Gln Glu Glu Leu Ile Ala Ser Leu Glu Glu Gln Leu Lys 
705                 710                 715                 720 


Leu Ser Gly Glu His Ser Glu Ser Ser Thr Pro Arg Pro Arg Ser Ser 
                725                 730                 735     


Pro Glu Glu Thr Ile Glu Pro Glu Ser Leu His Gln Leu Phe Glu Gly 
            740                 745                 750         


Glu Ser Glu Thr Glu Ser Phe Tyr Gly Phe Glu Glu Ala Asp Leu Asp 
        755                 760                 765             


Leu Met Glu Ile 
    770         


<210> 8861
<211> 94
<212> PRT
<213> Homo sapiens

<400> 8861
Met Ala Met Thr Ala Gly Thr Thr Thr Thr Phe Pro Met Ser Asn His 
1               5                   10                  15      


Thr Arg Glu Arg Val Thr Val Ala Lys Leu Thr Leu Glu Asn Phe Tyr 
            20                  25                  30          


Ser Asn Leu Ile Leu Gln His Glu Glu Arg Glu Thr Arg Gln Lys Lys 
        35                  40                  45              


Leu Glu Val Ala Met Glu Glu Glu Gly Leu Ala Asp Glu Glu Lys Lys 
    50                  55                  60                  


Leu Arg Arg Ser Gln His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Arg Leu Gly Leu Asp Asp Phe Glu Ser Leu Lys 
                85                  90                  


<210> 8862
<211> 348
<212> PRT
<213> Homo sapiens

<400> 8862
Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
1               5                   10                  15      


Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly Leu Tyr 
    50                  55                  60                  


Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
            100                 105                 110         


Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
        115                 120                 125             


Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
    130                 135                 140                 


Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu Pro Leu 
145                 150                 155                 160 


Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu Leu Arg 
                165                 170                 175     


Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met Lys Ile 
            180                 185                 190         


Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr Glu Asp 
        195                 200                 205             


Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly Thr Lys 
    210                 215                 220                 


Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile Pro Ala 
225                 230                 235                 240 


Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe Arg Arg 
                245                 250                 255     


Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys Glu Ala 
            260                 265                 270         


Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg Val Ile 
        275                 280                 285             


Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys Arg Leu 
    290                 295                 300                 


Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg Gly Asp 
305                 310                 315                 320 


Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr Pro Gln 
                325                 330                 335     


Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
            340                 345             


<210> 8863
<211> 295
<212> PRT
<213> Homo sapiens

<400> 8863
Met Pro Val His Thr Leu Ser Pro Gly Ala Pro Ser Ala Pro Ala Leu 
1               5                   10                  15      


Pro Cys Arg Leu Arg Thr Arg Val Pro Gly Tyr Leu Leu Arg Gly Pro 
            20                  25                  30          


Ala Asp Gly Gly Ala Arg Lys Pro Ser Ala Val Glu Arg Leu Glu Ala 
        35                  40                  45              


Asp Lys Ala Lys Tyr Val Lys Ser Leu His Val Ala Asn Thr Arg Gln 
    50                  55                  60                  


Glu Pro Val Gln Pro Leu Leu Ser Lys Gln Pro Leu Phe Ser Pro Glu 
65                  70                  75                  80  


Thr Arg Arg Thr Val Leu Thr Pro Ser Arg Arg Ala Leu Pro Gly Pro 
                85                  90                  95      


Cys Arg Arg Pro Gln Leu Asp Leu Asp Ile Leu Ser Ser Leu Ile Asp 
            100                 105                 110         


Leu Cys Asp Ser Pro Val Ser Pro Ala Glu Ala Ser Arg Thr Pro Gly 
        115                 120                 125             


Arg Ala Glu Gly Ala Gly Arg Pro Pro Pro Ala Thr Pro Pro Arg Pro 
    130                 135                 140                 


Pro Pro Ser Thr Ser Ala Val Arg Arg Val Asp Val Arg Pro Leu Pro 
145                 150                 155                 160 


Ala Ser Pro Ala Arg Pro Cys Pro Ser Pro Gly Pro Ala Ala Ala Ser 
                165                 170                 175     


Ser Pro Ala Arg Pro Pro Gly Leu Gln Arg Ser Lys Ser Asp Leu Ser 
            180                 185                 190         


Glu Arg Phe Ser Arg Ala Ala Ala Asp Leu Glu Arg Phe Phe Asn Phe 
        195                 200                 205             


Cys Gly Leu Asp Pro Glu Glu Ala Arg Gly Leu Gly Val Ala His Leu 
    210                 215                 220                 


Ala Arg Ala Ser Ser Asp Ile Val Ser Leu Ala Gly Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Gly Ser Ser Glu Gly Gly Cys Ser Arg Arg Ser Ser Val Thr Val 
                245                 250                 255     


Glu Glu Arg Ala Arg Glu Arg Val Pro Tyr Gly Val Ser Val Val Glu 
            260                 265                 270         


Arg Asn Ala Arg Val Ile Lys Trp Leu Tyr Gly Leu Arg Gln Ala Arg 
        275                 280                 285             


Glu Ser Pro Ala Ala Glu Gly 
    290                 295 


<210> 8864
<211> 85
<212> PRT
<213> Homo sapiens

<400> 8864
Met Pro Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr His Leu Cys Asp 
1               5                   10                  15      


Leu Cys Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp Ala Ala His Ile 
            20                  25                  30          


Lys Ser Lys Ser His Leu Asn Gln Leu Lys Lys Arg Arg Arg Leu Asp 
        35                  40                  45              


Ser Asp Ala Val Asn Thr Ile Glu Ser Gln Ser Val Ser Pro Asp His 
    50                  55                  60                  


Asn Lys Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln Asn Asp Gln Glu 
65                  70                  75                  80  


Leu Lys Cys Ser Val 
                85  


<210> 8865
<211> 131
<212> PRT
<213> Homo sapiens

<400> 8865
Met Ala Met Thr Ala Gly Thr Thr Thr Thr Phe Pro Met Ser Asn His 
1               5                   10                  15      


Thr Arg Glu Arg Val Thr Val Ala Lys Leu Thr Leu Glu Asn Phe Tyr 
            20                  25                  30          


Ser Asn Leu Ile Leu Gln His Glu Glu Arg Glu Thr Arg Gln Lys Lys 
        35                  40                  45              


Leu Glu Val Ala Met Glu Glu Glu Gly Leu Ala Asp Glu Glu Lys Lys 
    50                  55                  60                  


Leu Arg Arg Ser Gln His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Arg Leu Gly Leu Asp Asp Phe Glu Ser Leu Lys Val Ile 
                85                  90                  95      


Gly Arg Gly Ala Phe Gly Glu Val Arg Leu Val Gln Lys Lys Asp Thr 
            100                 105                 110         


Gly His Ile Tyr Ala Met Lys Ile Leu Arg Lys Ser Asp Met Leu Glu 
        115                 120                 125             


Lys Glu Gln 
    130     


<210> 8866
<211> 6
<212> PRT
<213> Homo sapiens

<400> 8866
Met Ala His Glu Met Ile 
1               5       


<210> 8867
<211> 732
<212> PRT
<213> Homo sapiens

<400> 8867
Met Gly Phe Arg Asp Glu Ala Ala Gly Tyr Phe His Lys Ala Val Lys 
1               5                   10                  15      


Leu Asn Pro Asp Phe Ser Asp Ala Lys Glu Asn Phe Tyr Arg Val Ala 
            20                  25                  30          


Asn Trp Leu Val Glu Arg Trp His Phe Ile Met Leu Asn Asp Thr Lys 
        35                  40                  45              


Arg Asn Thr Ile Tyr Asn Ala Ala Ile Gln Lys Ala Val Cys Leu Gly 
    50                  55                  60                  


Ser Lys Ser Val Leu Asp Ile Gly Ala Gly Thr Gly Ile Leu Ser Met 
65                  70                  75                  80  


Phe Ala Lys Lys Ala Gly Ala His Ser Val Tyr Ala Cys Glu Leu Ser 
                85                  90                  95      


Lys Thr Met Tyr Glu Leu Ala Cys Asp Val Val Ala Ala Asn Lys Met 
            100                 105                 110         


Glu Ala Gly Ile Lys Leu Leu His Thr Lys Ser Leu Asp Ile Glu Ile 
        115                 120                 125             


Pro Lys His Ile Pro Glu Arg Val Ser Leu Val Val Thr Glu Thr Val 
    130                 135                 140                 


Asp Ala Gly Leu Phe Gly Glu Gly Ile Val Glu Ser Leu Ile His Ala 
145                 150                 155                 160 


Trp Glu His Leu Leu Leu Gln Pro Lys Thr Lys Gly Glu Ser Ala Asn 
                165                 170                 175     


Cys Glu Lys Tyr Gly Lys Val Ile Pro Ala Ser Ala Val Ile Phe Gly 
            180                 185                 190         


Met Ala Val Glu Cys Ala Glu Ile Arg Arg His His Arg Val Gly Ile 
        195                 200                 205             


Lys Asp Ile Ala Gly Ile His Leu Pro Thr Asn Val Lys Phe Gln Ser 
    210                 215                 220                 


Pro Ala Tyr Ser Ser Val Asp Thr Glu Glu Thr Ile Glu Pro Tyr Thr 
225                 230                 235                 240 


Thr Glu Lys Met Ser Arg Val Pro Gly Gly Tyr Leu Ala Leu Thr Glu 
                245                 250                 255     


Cys Phe Glu Ile Met Thr Val Asp Phe Asn Asn Leu Gln Glu Leu Lys 
            260                 265                 270         


Ser Leu Ala Thr Lys Lys Pro Asp Lys Ile Gly Ile Pro Val Ile Lys 
        275                 280                 285             


Glu Gly Ile Leu Asp Ala Ile Met Val Trp Phe Val Leu Gln Leu Asp 
    290                 295                 300                 


Asp Glu His Ser Leu Ser Thr Ser Pro Ser Glu Glu Thr Cys Trp Glu 
305                 310                 315                 320 


Gln Ala Val Tyr Pro Val Gln Asp Leu Ala Asp Tyr Trp Ile Lys Pro 
                325                 330                 335     


Gly Asp His Val Met Met Glu Val Ser Cys Gln Asp Cys Tyr Leu Arg 
            340                 345                 350         


Ile Gln Ser Ile Ser Val Leu Gly Leu Glu Cys Glu Met Asp Val Ala 
        355                 360                 365             


Lys Ser Phe Thr Gln Asn Lys Asp Leu Leu Ser Leu Gly Asn Glu Ala 
    370                 375                 380                 


Glu Leu Cys Ser Ala Leu Ala Asn Leu Gln Thr Ser Lys Pro Asp Ala 
385                 390                 395                 400 


Val Glu Gln Thr Cys Ile Leu Glu Ser Thr Glu Ile Ala Leu Leu Asn 
                405                 410                 415     


Asn Ile Pro Tyr His Glu Gly Phe Lys Met Ala Met Ser Lys Val Leu 
            420                 425                 430         


Ser Ser Leu Thr Pro Glu Lys Leu Tyr Gln Thr Met Asp Thr His Cys 
        435                 440                 445             


Gln Asn Glu Met Ser Ser Gly Thr Gly Gln Ser Asn Thr Val Gln Asn 
    450                 455                 460                 


Ile Leu Glu Pro Phe Tyr Val Leu Asp Val Ser Glu Gly Phe Ser Val 
465                 470                 475                 480 


Leu Pro Val Ile Ala Gly Thr Leu Gly Gln Val Lys Pro Tyr Ser Ser 
                485                 490                 495     


Val Glu Lys Asp Gln His Arg Ile Ala Leu Asp Leu Ile Ser Glu Ala 
            500                 505                 510         


Asn His Phe Pro Lys Glu Thr Leu Glu Phe Trp Leu Arg His Val Glu 
        515                 520                 525             


Asp Glu Ser Ala Met Leu Gln Arg Pro Lys Ser Asp Lys Leu Trp Ser 
    530                 535                 540                 


Ile Ile Ile Leu Asp Val Ile Glu Pro Ser Gly Leu Ile Gln Gln Glu 
545                 550                 555                 560 


Ile Met Glu Lys Ala Ala Ile Ser Arg Cys Leu Leu Gln Ser Gly Gly 
                565                 570                 575     


Lys Ile Phe Pro Gln Tyr Val Leu Met Phe Gly Leu Leu Val Glu Ser 
            580                 585                 590         


Gln Thr Leu Leu Glu Glu Asn Ala Val Gln Gly Thr Glu Arg Thr Leu 
        595                 600                 605             


Gly Leu Asn Ile Ala Pro Phe Ile Asn Gln Phe Gln Val Pro Ile Arg 
    610                 615                 620                 


Val Phe Leu Asp Leu Ser Ser Leu Pro Cys Ile Pro Leu Ser Lys Pro 
625                 630                 635                 640 


Val Glu Leu Leu Arg Leu Asp Leu Met Thr Pro Tyr Leu Asn Thr Ser 
                645                 650                 655     


Asn Arg Glu Val Lys Val Tyr Val Cys Lys Ser Gly Arg Leu Thr Ala 
            660                 665                 670         


Ile Pro Phe Trp Tyr His Met Tyr Leu Asp Glu Glu Ile Arg Leu Asp 
        675                 680                 685             


Thr Ser Ser Glu Ala Ser His Trp Lys Gln Ala Ala Val Val Leu Asp 
    690                 695                 700                 


Asn Pro Ile Gln Val Glu Met Gly Glu Glu Leu Val Leu Ser Ile Gln 
705                 710                 715                 720 


His His Lys Ser Asn Val Ser Ile Thr Val Lys Gln 
                725                 730         


<210> 8868
<211> 517
<212> PRT
<213> Homo sapiens

<400> 8868
Met Cys Ser Leu Ala Ser Gly Ala Thr Gly Gly Arg Gly Ala Val Glu 
1               5                   10                  15      


Asn Glu Glu Asp Leu Pro Glu Leu Ser Asp Ser Gly Asp Glu Ala Ala 
            20                  25                  30          


Trp Glu Asp Glu Asp Asp Ala Asp Leu Pro His Gly Lys Gln Gln Thr 
        35                  40                  45              


Pro Cys Leu Phe Cys Asn Arg Leu Phe Thr Ser Ala Glu Glu Thr Phe 
    50                  55                  60                  


Ser His Cys Lys Ser Glu His Gln Phe Asn Ile Asp Ser Met Val His 
65                  70                  75                  80  


Lys His Gly Leu Glu Phe Tyr Gly Tyr Ile Lys Leu Ile Asn Phe Ile 
                85                  90                  95      


Arg Leu Lys Asn Pro Thr Val Glu Tyr Met Asn Ser Ile Tyr Asn Pro 
            100                 105                 110         


Val Pro Trp Glu Lys Glu Glu Tyr Leu Lys Pro Val Leu Glu Asp Asp 
        115                 120                 125             


Leu Leu Leu Gln Phe Asp Val Glu Asp Leu Tyr Glu Pro Val Ser Val 
    130                 135                 140                 


Pro Phe Ser Tyr Pro Asn Gly Leu Ser Glu Asn Thr Ser Val Val Glu 
145                 150                 155                 160 


Lys Leu Lys His Met Glu Ala Arg Ala Leu Ser Ala Glu Ala Ala Leu 
                165                 170                 175     


Ala Arg Ala Arg Glu Asp Leu Gln Lys Met Lys Gln Phe Ala Gln Asp 
            180                 185                 190         


Phe Val Met His Thr Asp Val Arg Thr Cys Ser Ser Ser Thr Ser Val 
        195                 200                 205             


Ile Ala Asp Leu Gln Glu Asp Glu Asp Gly Val Tyr Phe Ser Ser Tyr 
    210                 215                 220                 


Gly His Tyr Gly Ile His Glu Glu Met Leu Lys Asp Lys Ile Arg Thr 
225                 230                 235                 240 


Glu Ser Tyr Arg Asp Phe Ile Tyr Gln Asn Pro His Ile Phe Lys Asp 
                245                 250                 255     


Lys Val Val Leu Asp Val Gly Cys Gly Thr Gly Ile Leu Ser Met Phe 
            260                 265                 270         


Ala Ala Lys Ala Gly Ala Lys Lys Val Leu Gly Val Asp Gln Ser Glu 
        275                 280                 285             


Ile Leu Tyr Gln Ala Met Asp Ile Ile Arg Leu Asn Lys Leu Glu Asp 
    290                 295                 300                 


Thr Ile Thr Leu Ile Lys Gly Lys Ile Glu Glu Val His Leu Pro Val 
305                 310                 315                 320 


Glu Lys Val Asp Val Ile Ile Ser Glu Trp Met Gly Tyr Phe Leu Leu 
                325                 330                 335     


Phe Glu Ser Met Leu Asp Ser Val Leu Tyr Ala Lys Asn Lys Tyr Leu 
            340                 345                 350         


Ala Lys Gly Gly Ser Val Tyr Pro Asp Ile Cys Thr Ile Ser Leu Val 
        355                 360                 365             


Ala Val Ser Asp Val Asn Lys His Ala Asp Arg Ile Ala Phe Trp Asp 
    370                 375                 380                 


Asp Val Tyr Gly Phe Lys Met Ser Cys Met Lys Lys Ala Val Ile Pro 
385                 390                 395                 400 


Glu Ala Val Val Glu Val Leu Asp Pro Lys Thr Leu Ile Ser Glu Pro 
                405                 410                 415     


Cys Gly Ile Lys His Ile Asp Cys His Thr Thr Ser Ile Ser Asp Leu 
            420                 425                 430         


Glu Phe Ser Ser Asp Phe Thr Leu Lys Ile Thr Arg Thr Ser Met Cys 
        435                 440                 445             


Thr Ala Ile Ala Gly Tyr Phe Asp Ile Tyr Phe Glu Lys Asn Cys His 
    450                 455                 460                 


Asn Arg Val Val Phe Ser Thr Gly Pro Gln Ser Thr Lys Thr His Trp 
465                 470                 475                 480 


Lys Gln Thr Val Phe Leu Leu Glu Lys Pro Phe Ser Val Lys Ala Gly 
                485                 490                 495     


Glu Ala Leu Lys Gly Lys Val Thr Val His Lys Asn Lys Arg Glu Val 
            500                 505                 510         


Leu Ile Val Gly Ile 
        515         


<210> 8869
<211> 519
<212> PRT
<213> Homo sapiens

<400> 8869
Met Glu Gln Glu Lys Phe Asp Leu Gln Lys Gln His Thr Glu Asn Ile 
1               5                   10                  15      


Gln Glu Leu Leu Glu Asp Thr Asn Val Arg Leu Asn Lys Met Glu Ser 
            20                  25                  30          


Glu Tyr Met Ala Gln Thr Gln Ser Thr Asn His Met Ile Lys Glu Leu 
        35                  40                  45              


Glu Ala Arg Val Gln Gln Leu Thr Gly Glu Ala Glu Asn Ser Asn Leu 
    50                  55                  60                  


Gln Arg Gln Lys Leu Ile Gln Glu Lys Ala Glu Leu Glu Arg Cys Tyr 
65                  70                  75                  80  


Gln Ile Thr Cys Ser Glu Leu Gln Glu Val Lys Ala Arg Arg Asn Thr 
                85                  90                  95      


Leu His Lys Glu Lys Asp His Leu Val Asn Asp Tyr Glu Gln Asn Met 
            100                 105                 110         


Lys Leu Leu Gln Thr Lys Tyr Asp Ala Asp Ile Asn Leu Leu Lys Gln 
        115                 120                 125             


Glu His Ala Leu Ser Ala Ser Lys Ala Ser Ser Met Ile Glu Glu Leu 
    130                 135                 140                 


Glu Gln Asn Val Cys Gln Leu Lys Gln Gln Leu Gln Glu Ser Glu Leu 
145                 150                 155                 160 


Gln Arg Lys Gln Gln Leu Arg Asp Gln Glu Asn Lys Phe Gln Met Glu 
                165                 170                 175     


Lys Ser His Leu Lys His Ile Tyr Glu Lys Lys Ala His Asp Leu Gln 
            180                 185                 190         


Ser Glu Leu Asp Lys Gly Lys Glu Asp Thr Gln Lys Lys Ile His Lys 
        195                 200                 205             


Phe Glu Glu Ala Leu Lys Glu Lys Glu Glu Gln Leu Thr Arg Val Thr 
    210                 215                 220                 


Glu Val Gln Arg Leu Gln Ala Gln Gln Ala Asp Ala Ala Leu Glu Glu 
225                 230                 235                 240 


Phe Lys Arg Gln Val Glu Leu Asn Ser Glu Lys Val Tyr Ala Glu Met 
                245                 250                 255     


Lys Glu Gln Met Glu Lys Val Glu Ala Asp Leu Thr Arg Ser Lys Ser 
            260                 265                 270         


Leu Arg Glu Lys Gln Ser Lys Glu Phe Leu Trp Gln Leu Glu Asp Ile 
        275                 280                 285             


Arg Gln Arg Tyr Glu Gln Gln Ile Val Glu Leu Lys Leu Glu His Glu 
    290                 295                 300                 


Gln Glu Lys Thr His Leu Leu Gln Gln His Asn Ala Glu Lys Asp Ser 
305                 310                 315                 320 


Leu Val Arg Asp His Glu Arg Glu Ile Glu Asn Leu Glu Lys Gln Leu 
                325                 330                 335     


Arg Ala Ala Asn Met Glu His Glu Asn Gln Ile Gln Glu Phe Lys Lys 
            340                 345                 350         


Arg Asp Ala Gln Val Ile Ala Asp Met Glu Ala Gln Val His Lys Leu 
        355                 360                 365             


Arg Glu Glu Leu Ile Asn Val Asn Ser Gln Arg Lys Gln Gln Leu Val 
    370                 375                 380                 


Glu Leu Gly Leu Leu Arg Glu Glu Glu Lys Gln Arg Ala Thr Arg Glu 
385                 390                 395                 400 


His Glu Ile Val Val Asn Lys Leu Lys Ala Glu Ser Glu Lys Met Lys 
                405                 410                 415     


Ile Glu Leu Lys Lys Thr His Ala Ala Glu Thr Glu Met Thr Leu Glu 
            420                 425                 430         


Lys Val Leu Gln Asp Glu Leu Glu Asn Arg Ser Asn Gln Val Arg Cys 
        435                 440                 445             


Ala Glu Lys Lys Leu Gln His Lys Glu Leu Glu Ser Gln Glu Gln Ile 
    450                 455                 460                 


Thr Tyr Ile Arg Gln Glu Tyr Glu Thr Lys Leu Lys Gly Leu Met Pro 
465                 470                 475                 480 


Ala Ser Leu Arg Gln Glu Leu Glu Asp Thr Ile Ser Ser Leu Lys Ser 
                485                 490                 495     


Gln Val Asn Phe Leu Gln Lys Arg Ala Ser Ile Leu Gln Glu Glu Leu 
            500                 505                 510         


Thr Thr Tyr Gln Gly Arg Arg 
        515                 


<210> 8870
<211> 580
<212> PRT
<213> Homo sapiens

<400> 8870
Met Asn Asn Ile His Val Glu Asn Glu Ser Leu Asp Asn Phe Leu Lys 
1               5                   10                  15      


Glu Thr Asn Lys Glu Asn Leu Leu Asp Ile Leu Thr Glu Pro Glu Arg 
            20                  25                  30          


Lys Pro Asp Pro Lys Leu Tyr Thr Arg Ser Lys Pro Lys Thr Asp Ser 
        35                  40                  45              


Tyr Asn Gln Thr Lys Asn Ser Leu Val Pro Lys Gln Ala Leu Gly Lys 
    50                  55                  60                  


Ser Ser Val Asn Ser Ala Val Leu Lys Asp Arg Val Asn Lys Gln Phe 
65                  70                  75                  80  


Val Gly Glu Thr Gln Ser Arg Thr Phe Pro Val Lys Ser Gln Gln Leu 
                85                  90                  95      


Ser Arg Gly Ala Asp Leu Ala Arg Pro Gly Val Lys Pro Ser Arg Thr 
            100                 105                 110         


Val Pro Ser His Phe Ile Arg Thr Leu Ser Lys Val Gln Ser Ser Lys 
        115                 120                 125             


Lys Pro Val Val Lys Asn Ile Lys Asp Ile Lys Val Asn Arg Ser Gln 
    130                 135                 140                 


Tyr Glu Arg Pro Asn Glu Thr Lys Ile Arg Ser Tyr Pro Val Thr Glu 
145                 150                 155                 160 


Gln Arg Val Lys His Thr Lys Pro Arg Thr Tyr Pro Ser Leu Leu Gln 
                165                 170                 175     


Gly Glu Tyr Asn Asn Arg His Pro Asn Ile Lys Gln Asp Gln Lys Ser 
            180                 185                 190         


Ser Gln Val Cys Ile Pro Gln Thr Ser Cys Val Leu Gln Lys Ser Lys 
        195                 200                 205             


Ala Ile Ser Gln Arg Pro Asn Leu Thr Val Gly Arg Phe Asn Ser Ala 
    210                 215                 220                 


Ile Pro Ser Thr Pro Ser Ile Arg Pro Asn Gly Thr Ser Gly Asn Lys 
225                 230                 235                 240 


His Asn Asn Asn Gly Phe Gln Gln Lys Ala Gln Thr Leu Asp Ser Lys 
                245                 250                 255     


Leu Lys Lys Ala Val Pro Gln Asn His Phe Leu Asn Lys Thr Ala Pro 
            260                 265                 270         


Lys Thr Gln Ala Asp Val Thr Thr Val Asn Gly Thr Gln Thr Asn Pro 
        275                 280                 285             


Asn Ile Lys Lys Lys Ala Thr Ala Glu Asp Arg Arg Lys Gln Leu Glu 
    290                 295                 300                 


Glu Trp Gln Lys Ser Lys Gly Lys Thr Tyr Lys Arg Pro Pro Met Glu 
305                 310                 315                 320 


Leu Lys Thr Lys Arg Lys Val Ile Lys Glu Met Asn Ile Ser Phe Trp 
                325                 330                 335     


Lys Ser Ile Glu Lys Glu Glu Glu Glu Lys Lys Ala Gln Leu Glu Leu 
            340                 345                 350         


Ser Ser Lys Ile Asn Asn Thr Leu Thr Glu Cys Leu Asn Leu Ile Glu 
        355                 360                 365             


Gly Gly Val Pro Ser Asn Glu Ile Leu Asn Ile Leu Ser Ser Ile Pro 
    370                 375                 380                 


Glu Ala Glu Lys Phe Ala Lys Phe Trp Ile Cys Lys Ala Lys Leu Leu 
385                 390                 395                 400 


Ala Ser Lys Gly Thr Phe Asp Val Ile Gly Leu Tyr Glu Glu Ala Ile 
                405                 410                 415     


Lys Asn Gly Ala Thr Pro Ile Gln Glu Leu Arg Lys Val Val Leu Asn 
            420                 425                 430         


Ile Leu Gln Asp Ser Asn Arg Thr Thr Glu Gly Ile Thr Ser Asp Ser 
        435                 440                 445             


Leu Val Ala Glu Thr Ser Ile Thr Ser Val Glu Glu Leu Ala Lys Lys 
    450                 455                 460                 


Met Glu Ser Val Lys Ser Cys Leu Ser Pro Lys Glu Arg Glu Gln Val 
465                 470                 475                 480 


Thr Ala Thr Pro Arg Ile Ala Lys Ala Glu Gln His Asn Tyr Pro Gly 
                485                 490                 495     


Ile Lys Leu Gln Ile Gly Pro Ile Pro Arg Ile Asn Gly Met Pro Glu 
            500                 505                 510         


Val Gln Asp Met Lys Phe Ile Thr Pro Val Arg Arg Ser Ser Arg Ile 
        515                 520                 525             


Glu Arg Ala Val Ser Arg Tyr Pro Glu Met Leu Gln Glu His Asp Leu 
    530                 535                 540                 


Val Val Ala Ser Leu Asp Glu Leu Leu Glu Val Glu Glu Thr Lys Cys 
545                 550                 555                 560 


Phe Ile Phe Arg Arg Asn Glu Ala Leu Pro Val Thr Leu Gly Phe Gln 
                565                 570                 575     


Thr Pro Glu Ser 
            580 


<210> 8871
<211> 234
<212> PRT
<213> Homo sapiens

<400> 8871
Met Tyr Met Asp Leu Val Asp Gly Ile Phe Leu Asn Gln Ile Met Leu 
1               5                   10                  15      


Gln Ile Asp Pro Arg Pro Thr Asn Gln Arg Ile Asn Lys His Val Asn 
            20                  25                  30          


Asn Asp Val Asn Leu Arg Ile Gln Asn Leu Thr Ile Leu Val Arg Asn 
        35                  40                  45              


Ile Lys Thr Tyr Tyr Gln Glu Val Leu Gln Gln Leu Ile Val Met Asn 
    50                  55                  60                  


Leu Pro Asn Val Leu Met Ile Gly Arg Asp Pro Leu Ser Gly Lys Ser 
65                  70                  75                  80  


Met Glu Glu Ile Lys Lys Val Leu Leu Leu Val Leu Gly Cys Ala Val 
                85                  90                  95      


Gln Cys Glu Arg Lys Glu Glu Phe Ile Glu Arg Ile Lys Gln Leu Asp 
            100                 105                 110         


Ile Glu Thr Gln Ala Gly Ile Val Ala His Ile Gln Glu Val Thr His 
        115                 120                 125             


Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Leu Glu Leu Pro Asp Val 
    130                 135                 140                 


Ala Pro Glu Glu Leu Glu Ala Leu Ser Arg Ser Met Val Leu His Leu 
145                 150                 155                 160 


Arg Arg Leu Ile Asp Gln Arg Asp Glu Cys Thr Glu Leu Ile Val Asp 
                165                 170                 175     


Leu Thr Gln Glu Arg Asp Tyr Leu Gln Ala Gln His Pro Pro Ser Pro 
            180                 185                 190         


Ile Lys Ser Ser Ser Ala Asp Ser Thr Pro Ser Pro Thr Ser Ser Leu 
        195                 200                 205             


Ser Ser Glu Asp Lys Gln His Leu Ala Val Glu Leu Ala Asp Thr Lys 
    210                 215                 220                 


Ala Arg Leu Arg Arg Val Arg Gln Glu Leu 
225                 230                 


<210> 8872
<211> 386
<212> PRT
<213> Homo sapiens

<400> 8872
Met Thr Asp Ile Arg Lys Ile Arg Leu Gly Glu Arg Leu Val Glu Val 
1               5                   10                  15      


Phe Ser Ala Glu Lys Val Tyr Met Val Arg Leu Arg Asn Pro Leu Gly 
            20                  25                  30          


Arg Gln Glu Trp Ser Gly Pro Trp Ser Glu Ile Ser Glu Glu Trp Gln 
        35                  40                  45              


Gln Leu Thr Ala Ser Asp Arg Lys Asn Leu Gly Leu Val Met Ser Asp 
    50                  55                  60                  


Asp Gly Glu Phe Trp Met Ser Leu Glu Asp Phe Cys Arg Asn Phe His 
65                  70                  75                  80  


Lys Leu Asn Val Cys Arg Asn Val Asn Asn Pro Ile Phe Gly Arg Lys 
                85                  90                  95      


Glu Leu Glu Ser Val Leu Gly Cys Trp Thr Val Asp Asp Asp Pro Leu 
            100                 105                 110         


Met Asn Arg Ser Gly Gly Cys Tyr Asn Asn Arg Asp Thr Phe Leu Gln 
        115                 120                 125             


Asn Pro Gln Tyr Ile Phe Thr Val Pro Glu Asp Gly His Lys Val Ile 
    130                 135                 140                 


Met Ser Leu Gln Gln Lys Asp Leu Arg Thr Tyr Arg Arg Met Gly Arg 
145                 150                 155                 160 


Pro Asp Asn Tyr Ile Ile Gly Phe Glu Leu Phe Lys Val Glu Met Asn 
                165                 170                 175     


Arg Lys Phe Arg Leu His His Leu Tyr Ile Gln Glu Arg Ala Gly Thr 
            180                 185                 190         


Ser Thr Tyr Ile Asp Thr Arg Thr Val Phe Leu Ser Lys Tyr Leu Lys 
        195                 200                 205             


Lys Gly Asn Tyr Val Leu Val Pro Thr Met Phe Gln His Gly Arg Thr 
    210                 215                 220                 


Ser Glu Phe Leu Leu Arg Ile Phe Ser Glu Val Pro Val Gln Leu Arg 
225                 230                 235                 240 


Glu Leu Thr Leu Asp Met Pro Lys Met Ser Cys Trp Asn Leu Ala Arg 
                245                 250                 255     


Gly Tyr Pro Lys Val Val Thr Gln Ile Thr Val His Ser Ala Glu Asp 
            260                 265                 270         


Leu Glu Lys Lys Tyr Ala Asn Glu Thr Val Asn Pro Tyr Leu Val Ile 
        275                 280                 285             


Lys Cys Gly Lys Glu Glu Val Arg Ser Pro Val Gln Lys Asn Thr Val 
    290                 295                 300                 


His Ala Ile Phe Asp Thr Gln Ala Ile Phe Tyr Arg Arg Thr Thr Asp 
305                 310                 315                 320 


Ile Pro Ile Ile Val Gln Val Trp Asn Ser Arg Lys Phe Cys Asp Gln 
                325                 330                 335     


Phe Leu Gly Gln Val Thr Leu Asp Ala Asp Pro Ser Asp Cys Arg Asp 
            340                 345                 350         


Leu Lys Ser Leu Tyr Leu Arg Lys Lys Gly Gly Pro Thr Ala Lys Val 
        355                 360                 365             


Lys Gln Gly His Ile Ser Phe Lys Val Ile Ser Ser Asp Asp Leu Thr 
    370                 375                 380                 


Glu Leu 
385     


<210> 8873
<211> 321
<212> PRT
<213> Homo sapiens

<400> 8873
Met Thr Glu Leu Ser Leu Gln Lys Glu Gln Leu Gln Leu Lys Ile Ile 
1               5                   10                  15      


Glu Ile Glu Asp Glu Ala Glu Lys Trp Gln Lys Glu Lys Asp Arg Ile 
            20                  25                  30          


Lys Ser Phe Thr Thr Asn Glu Lys Ala Ile Leu Glu Gln Asn Phe Arg 
        35                  40                  45              


Asp Leu Val Arg Asp Leu Glu Lys Gln Lys Glu Glu Val Arg Ala Ala 
    50                  55                  60                  


Leu Glu Gln Arg Glu Gln Asp Ala Val Asp Gln Val Lys Val Ile Met 
65                  70                  75                  80  


Asp Ala Leu Asp Glu Arg Ala Lys Val Leu His Glu Asp Lys Gln Thr 
                85                  90                  95      


Arg Glu Gln Leu His Ser Ile Ser Asp Ser Val Leu Phe Leu Gln Glu 
            100                 105                 110         


Phe Gly Ala Leu Met Ser Asn Tyr Ser Leu Pro Pro Pro Leu Pro Thr 
        115                 120                 125             


Tyr His Val Leu Leu Glu Gly Glu Gly Leu Gly Gln Ser Leu Gly Asn 
    130                 135                 140                 


Phe Lys Asp Asp Leu Leu Asn Val Cys Met Arg His Val Glu Lys Met 
145                 150                 155                 160 


Cys Lys Ala Asp Leu Ser Arg Asn Phe Ile Glu Arg Asn His Met Glu 
                165                 170                 175     


Asn Gly Gly Asp His Arg Tyr Val Asn Asn Tyr Thr Asn Ser Phe Gly 
            180                 185                 190         


Gly Glu Trp Ser Ala Pro Asp Thr Met Lys Arg Tyr Ser Met Tyr Leu 
        195                 200                 205             


Thr Pro Lys Gly Gly Val Arg Thr Ser Tyr Gln Pro Ser Ser Pro Gly 
    210                 215                 220                 


Arg Phe Thr Lys Glu Thr Thr Gln Lys Asn Phe Asn Asn Leu Tyr Gly 
225                 230                 235                 240 


Thr Lys Gly Asn Tyr Thr Ser Arg Val Trp Glu Tyr Ser Ser Ser Ile 
                245                 250                 255     


Gln Asn Ser Asp Asn Asp Leu Pro Val Val Gln Gly Ser Ser Ser Phe 
            260                 265                 270         


Ser Leu Lys Gly Tyr Pro Ser Leu Met Arg Ser Gln Ser Pro Lys Ala 
        275                 280                 285             


Gln Pro Gln Thr Trp Lys Ser Gly Lys Gln Thr Met Leu Ser His Tyr 
    290                 295                 300                 


Arg Pro Phe Tyr Val Asn Lys Gly Asn Gly Ile Gly Ser Asn Glu Ala 
305                 310                 315                 320 


Pro 
    


<210> 8874
<211> 228
<212> PRT
<213> Homo sapiens

<400> 8874
Met Tyr Arg Gln Arg Phe Leu Tyr Ser Leu Tyr Arg His Thr His Trp 
1               5                   10                  15      


Val Arg Cys Ala Lys Phe Ser Pro Asp Gly Arg Leu Ile Val Ser Cys 
            20                  25                  30          


Ser Glu Asp Lys Thr Ile Lys Ile Trp Asp Thr Thr Asn Lys Gln Cys 
        35                  40                  45              


Val Asn Asn Phe Ser Asp Ser Val Gly Phe Ala Asn Phe Val Asp Phe 
    50                  55                  60                  


Asn Pro Ser Gly Thr Cys Ile Ala Ser Ala Gly Ser Asp Gln Thr Val 
65                  70                  75                  80  


Lys Val Trp Asp Val Arg Val Asn Lys Leu Leu Gln His Tyr Gln Val 
                85                  90                  95      


His Ser Gly Gly Val Asn Cys Ile Ser Phe His Pro Ser Gly Asn Tyr 
            100                 105                 110         


Leu Ile Thr Ala Ser Ser Asp Gly Thr Leu Lys Ile Leu Asp Leu Leu 
        115                 120                 125             


Glu Gly Arg Leu Ile Tyr Thr Leu Gln Gly His Thr Gly Pro Val Phe 
    130                 135                 140                 


Thr Val Ser Phe Ser Lys Gly Gly Glu Leu Phe Ala Ser Gly Gly Ala 
145                 150                 155                 160 


Asp Thr Gln Val Leu Leu Trp Arg Thr Asn Phe Asp Glu Leu His Cys 
                165                 170                 175     


Lys Gly Leu Thr Lys Arg Asn Leu Lys Arg Leu His Phe Asp Ser Pro 
            180                 185                 190         


Pro His Leu Leu Asp Ile Tyr Pro Arg Thr Pro His Pro His Glu Glu 
        195                 200                 205             


Lys Val Glu Thr Val Glu Asp Phe Phe Leu His Leu Leu Arg Leu Ile 
    210                 215                 220                 


Gln Ser Leu Arg 
225             


<210> 8875
<211> 561
<212> PRT
<213> Homo sapiens

<400> 8875
Met Arg Ala Val Arg Arg His Leu Phe Pro Gln His Ser Ala Pro Gly 
1               5                   10                  15      


Arg Gly Val Val Trp Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala 
            20                  25                  30          


Tyr Glu Ala Ser Val Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly 
        35                  40                  45              


Asn Gln Leu Val Asp Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn 
    50                  55                  60                  


Tyr Thr Thr His Thr Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser 
65                  70                  75                  80  


Val Arg Arg Gln Ala Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala 
                85                  90                  95      


Pro Pro Gly His Thr Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser 
            100                 105                 110         


Gly Ser Arg Thr Gly Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr 
        115                 120                 125             


Asn Leu Pro Ala Tyr Pro Val Pro Gln His Pro Pro His Arg Thr Ala 
    130                 135                 140                 


Ser Val Phe Gly Thr His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser 
145                 150                 155                 160 


Leu Ser Gly Ala Arg Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp 
                165                 170                 175     


Gly Ala Ala Pro Pro Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser 
            180                 185                 190         


Leu Ser His Leu Gly Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser 
        195                 200                 205             


Gly Ala Val Ser Ala Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly 
    210                 215                 220                 


Ser Val Pro Ala Thr Val Pro Met Gln Met Pro Lys Pro Ser Arg Val 
225                 230                 235                 240 


Gln Gln Ala Leu Ala Gly Met Thr Ser Val Leu Met Ser Ala Ile Gly 
                245                 250                 255     


Leu Pro Val Cys Leu Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro Ala 
            260                 265                 270         


Ser Arg Leu Ala Ser Lys Ser His Gly Ser Val Lys Arg Leu Arg Lys 
        275                 280                 285             


Met Ser Val Lys Gly Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln 
    290                 295                 300                 


Val Ile Lys Asn Tyr Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp 
305                 310                 315                 320 


Cys Ile Ile Cys Met Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser Asp 
                325                 330                 335     


Val Thr Asp Ser Lys Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr 
            340                 345                 350         


Lys Cys Ser His Ala Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys 
        355                 360                 365             


Asn Gly Asn Lys Asp Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile 
    370                 375                 380                 


Tyr Gly Glu Lys Thr Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu 
385                 390                 395                 400 


Arg Phe Gln Met Ser Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu 
                405                 410                 415     


Ile Val Tyr Ser Ile Pro His Gly Ile Gln Gly Pro Glu His Pro Asn 
            420                 425                 430         


Pro Gly Lys Pro Phe Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu 
        435                 440                 445             


Pro Asp Asn Ala Gln Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala 
    450                 455                 460                 


Trp Lys Arg Arg Leu Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly 
465                 470                 475                 480 


Glu Thr Asp Thr Val Val Trp Asn Glu Ile His His Lys Thr Glu Met 
                485                 490                 495     


Asp Arg Asn Ile Thr Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln 
            500                 505                 510         


Asn Val Leu Ala Glu Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu 
        515                 520                 525             


Glu Gln Gln His Ala Arg Leu Trp Trp Pro Pro Arg Cys Pro Met Ala 
    530                 535                 540                 


Gly Trp Val Ala Arg Gln Glu Val Pro Ser Pro Arg Gly Trp Glu Val 
545                 550                 555                 560 


Cys 
    


<210> 8876
<211> 854
<212> PRT
<213> Homo sapiens

<400> 8876
Met Lys Val Glu Ala Cys Thr Trp Ala Gly Tyr Ser Gly Leu Tyr Glu 
1               5                   10                  15      


Ala Ile Glu Ser Trp Asp Phe Lys Lys Ile Glu Lys Leu Glu Glu Tyr 
            20                  25                  30          


Arg Leu Leu Leu Lys Arg Leu Gln Pro Glu Phe Lys Thr Arg Ile Ile 
        35                  40                  45              


Pro Thr Asp Ile Ile Ser Asp Leu Ser Glu Cys Leu Ile Asn Gln Glu 
    50                  55                  60                  


Cys Glu Glu Ile Leu Gln Ile Cys Ser Thr Lys Gly Met Met Ala Gly 
65                  70                  75                  80  


Ala Glu Lys Leu Val Glu Cys Leu Leu Arg Ser Asp Lys Glu Asn Trp 
                85                  90                  95      


Pro Lys Thr Leu Lys Leu Ala Leu Glu Lys Glu Arg Asn Lys Phe Ser 
            100                 105                 110         


Glu Leu Trp Ile Val Glu Lys Gly Ile Lys Asp Val Glu Thr Glu Asp 
        115                 120                 125             


Leu Glu Asp Lys Met Glu Thr Ser Asp Ile Gln Ile Phe Tyr Gln Glu 
    130                 135                 140                 


Asp Pro Glu Cys Gln Asn Leu Ser Glu Asn Ser Cys Pro Pro Ser Glu 
145                 150                 155                 160 


Val Ser Asp Thr Asn Leu Tyr Ser Pro Phe Lys Pro Arg Asn Tyr Gln 
                165                 170                 175     


Leu Glu Leu Ala Leu Pro Ala Met Lys Gly Lys Asn Thr Ile Ile Cys 
            180                 185                 190         


Ala Pro Thr Gly Cys Gly Lys Thr Phe Val Ser Leu Leu Ile Cys Glu 
        195                 200                 205             


His His Leu Lys Lys Phe Pro Gln Gly Gln Lys Gly Lys Val Val Phe 
    210                 215                 220                 


Phe Ala Asn Gln Ile Pro Val Tyr Glu Gln Gln Lys Ser Val Phe Ser 
225                 230                 235                 240 


Lys Tyr Phe Glu Arg His Gly Tyr Arg Val Thr Gly Ile Ser Gly Ala 
                245                 250                 255     


Thr Ala Glu Asn Val Pro Val Glu Gln Ile Val Glu Asn Asn Asp Ile 
            260                 265                 270         


Ile Ile Leu Thr Pro Gln Ile Leu Val Asn Asn Leu Lys Lys Gly Thr 
        275                 280                 285             


Ile Pro Ser Leu Ser Ile Phe Thr Leu Met Ile Phe Asp Glu Cys His 
    290                 295                 300                 


Asn Thr Ser Lys Gln His Pro Tyr Asn Met Ile Met Phe Asn Tyr Leu 
305                 310                 315                 320 


Asp Gln Lys Leu Gly Gly Ser Ser Gly Pro Leu Pro Gln Val Ile Gly 
                325                 330                 335     


Leu Thr Ala Ser Val Gly Val Gly Asp Ala Lys Asn Thr Asp Glu Ala 
            340                 345                 350         


Leu Asp Tyr Ile Cys Lys Leu Cys Ala Ser Leu Asp Ala Ser Val Ile 
        355                 360                 365             


Ala Thr Val Lys His Asn Leu Glu Glu Leu Glu Gln Val Val Tyr Lys 
    370                 375                 380                 


Pro Gln Lys Phe Phe Arg Lys Val Glu Ser Arg Ile Ser Asp Lys Phe 
385                 390                 395                 400 


Lys Tyr Ile Ile Ala Gln Leu Met Arg Asp Thr Glu Ser Leu Ala Lys 
                405                 410                 415     


Arg Ile Cys Lys Asp Leu Glu Asn Leu Ser Gln Ile Gln Asn Arg Glu 
            420                 425                 430         


Phe Gly Thr Gln Lys Tyr Glu Gln Trp Ile Val Thr Val Gln Lys Ala 
        435                 440                 445             


Cys Met Val Phe Gln Met Pro Asp Lys Asp Glu Glu Ser Arg Ile Cys 
    450                 455                 460                 


Lys Ala Leu Phe Leu Tyr Thr Ser His Leu Arg Lys Tyr Asn Asp Ala 
465                 470                 475                 480 


Leu Ile Ile Ser Glu His Ala Arg Met Lys Asp Ala Leu Asp Tyr Leu 
                485                 490                 495     


Lys Asp Phe Phe Ser Asn Val Arg Ala Ala Gly Phe Asp Glu Ile Glu 
            500                 505                 510         


Gln Asp Leu Thr Gln Arg Phe Glu Glu Lys Leu Gln Glu Leu Glu Ser 
        515                 520                 525             


Val Ser Arg Asp Pro Ser Asn Glu Asn Pro Lys Leu Glu Asp Leu Cys 
    530                 535                 540                 


Phe Ile Leu Gln Glu Glu Tyr His Leu Asn Pro Glu Thr Ile Thr Ile 
545                 550                 555                 560 


Leu Phe Val Lys Thr Arg Ala Leu Val Asp Ala Leu Lys Asn Trp Ile 
                565                 570                 575     


Glu Gly Asn Pro Lys Leu Ser Phe Leu Lys Pro Gly Ile Leu Thr Gly 
            580                 585                 590         


Arg Gly Lys Thr Asn Gln Asn Thr Gly Met Thr Leu Pro Ala Gln Lys 
        595                 600                 605             


Cys Ile Leu Asp Ala Phe Lys Ala Ser Gly Asp His Asn Ile Leu Ile 
    610                 615                 620                 


Ala Thr Ser Val Ala Asp Glu Gly Ile Asp Ile Ala Gln Cys Asn Leu 
625                 630                 635                 640 


Val Ile Leu Tyr Glu Tyr Val Gly Asn Val Ile Lys Met Ile Gln Thr 
                645                 650                 655     


Arg Gly Arg Gly Arg Ala Arg Gly Ser Lys Cys Phe Leu Leu Thr Ser 
            660                 665                 670         


Asn Ala Gly Val Ile Glu Lys Glu Gln Ile Asn Met Tyr Lys Glu Lys 
        675                 680                 685             


Met Met Asn Asp Ser Ile Leu Arg Leu Gln Thr Trp Asp Glu Ala Val 
    690                 695                 700                 


Phe Arg Glu Lys Ile Leu His Ile Gln Thr His Glu Lys Phe Ile Arg 
705                 710                 715                 720 


Asp Ser Gln Glu Lys Pro Lys Pro Val Pro Asp Lys Glu Asn Lys Lys 
                725                 730                 735     


Leu Leu Cys Arg Lys Cys Lys Ala Leu Ala Cys Tyr Thr Ala Asp Val 
            740                 745                 750         


Arg Val Ile Glu Glu Cys His Tyr Thr Val Leu Gly Asp Ala Phe Lys 
        755                 760                 765             


Glu Cys Phe Val Ser Arg Pro His Pro Lys Pro Lys Gln Phe Ser Ser 
    770                 775                 780                 


Phe Glu Lys Arg Ala Lys Ile Phe Cys Ala Arg Gln Asn Cys Ser His 
785                 790                 795                 800 


Asp Trp Gly Ile His Val Lys Tyr Lys Thr Phe Glu Ile Pro Val Ile 
                805                 810                 815     


Lys Ile Glu Ser Phe Val Val Glu Asp Ile Ala Thr Gly Val Gln Thr 
            820                 825                 830         


Leu Tyr Ser Lys Trp Lys Asp Phe His Phe Glu Lys Ile Pro Phe Asp 
        835                 840                 845             


Pro Ala Glu Met Ser Lys 
    850                 


<210> 8877
<211> 270
<212> PRT
<213> Homo sapiens

<400> 8877
Met Gln Ile Glu His Ile Ile Glu Asn Ile Val Ala Val Thr Lys Gly 
1               5                   10                  15      


Leu Ser Glu Lys Leu Pro Glu Lys Trp Glu Ser Val Lys Leu Leu Phe 
            20                  25                  30          


Val Lys Thr Glu Lys Ser Ala Ala Leu Pro Ile Phe Ser Ser Phe Val 
        35                  40                  45              


Ser Asn Trp Asp Glu Ala Thr Lys Arg Ser Leu Leu Asn Lys Lys Lys 
    50                  55                  60                  


Lys Glu Ala Arg Arg Lys Arg Arg Glu Arg Asn Phe Glu Lys Gln Lys 
65                  70                  75                  80  


Glu Arg Lys Lys Lys Arg Gln Gln Ala Arg Lys Thr Ala Ser Val Leu 
                85                  90                  95      


Ser Lys Asp Asp Val Ala Pro Glu Ser Gly Asp Thr Thr Val Lys Lys 
            100                 105                 110         


Pro Glu Ser Lys Lys Glu Gln Thr Pro Glu His Gly Lys Lys Lys Arg 
        115                 120                 125             


Gly Arg Gly Lys Ala Gln Val Lys Ala Thr Asn Glu Ser Glu Asp Glu 
    130                 135                 140                 


Ile Pro Gln Leu Val Pro Ile Gly Lys Lys Thr Pro Ala Asn Glu Lys 
145                 150                 155                 160 


Val Glu Ile Gln Lys His Ala Thr Gly Lys Lys Ser Pro Ala Lys Ser 
                165                 170                 175     


Pro Asn Pro Ser Thr Pro Arg Gly Lys Lys Arg Lys Ala Leu Pro Ala 
            180                 185                 190         


Ser Glu Thr Pro Lys Ala Ala Glu Ser Glu Thr Pro Gly Lys Ser Pro 
        195                 200                 205             


Glu Lys Lys Pro Lys Ile Lys Glu Glu Ala Val Lys Glu Lys Ser Pro 
    210                 215                 220                 


Ser Leu Gly Lys Lys Asp Ala Arg Gln Thr Pro Lys Lys Pro Glu Ala 
225                 230                 235                 240 


Lys Phe Phe Thr Thr Pro Ser Lys Ser Val Arg Lys Ala Ser His Thr 
                245                 250                 255     


Pro Lys Lys Trp Pro Lys Lys Pro Lys Val Pro Gln Ser Thr 
            260                 265                 270 


<210> 8878
<211> 352
<212> PRT
<213> Homo sapiens

<400> 8878
Met Ser Ser Arg Lys Leu Ser Gly Pro Lys Gly Arg Arg Leu Ser Ile 
1               5                   10                  15      


His Val Val Thr Trp Asn Val Ala Ser Ala Ala Pro Pro Leu Asp Leu 
            20                  25                  30          


Ser Asp Leu Leu Gln Leu Asn Asn Arg Asn Leu Asn Leu Asp Ile Tyr 
        35                  40                  45              


Val Ile Gly Leu Gln Glu Leu Asn Ser Gly Ile Ile Ser Leu Leu Ser 
    50                  55                  60                  


Asp Ala Ala Phe Asn Asp Ser Trp Ser Ser Phe Leu Met Asp Val Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Phe Ile Lys Val Ser His Val Arg Met Gln Gly Ile 
                85                  90                  95      


Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro Tyr Ile Gln Ile 
            100                 105                 110         


Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly Tyr Trp Leu Ser 
        115                 120                 125             


Ile Ala Lys Lys His Asp Pro Leu Leu Arg Glu Phe Gln Glu Gly Arg 
    130                 135                 140                 


Leu Leu Phe Pro Pro Thr Tyr Lys Phe Asp Arg Asn Ser Asn Asp Tyr 
145                 150                 155                 160 


Asp Thr Ser Glu Lys Lys Arg Lys Pro Ala Trp Thr Asp Arg Ile Leu 
                165                 170                 175     


Trp Arg Leu Lys Arg Gln Pro Cys Ala Gly Pro Asp Thr Pro Ile Pro 
            180                 185                 190         


Pro Ala Ser His Phe Ser Leu Ser Leu Arg Gly Tyr Ser Ser His Met 
        195                 200                 205             


Thr Tyr Gly Ile Ser Asp His Lys Pro Val Ser Gly Thr Phe Asp Leu 
    210                 215                 220                 


Glu Leu Lys Pro Leu Val Ser Ala Pro Leu Ile Val Leu Met Pro Glu 
225                 230                 235                 240 


Asp Leu Trp Thr Val Glu Asn Asp Met Met Val Ser Tyr Ser Ser Thr 
                245                 250                 255     


Ser Asp Phe Pro Ser Ser Pro Trp Asp Trp Ile Gly Leu Tyr Lys Val 
            260                 265                 270         


Gly Leu Arg Asp Val Asn Asp Tyr Val Ser Tyr Ala Trp Val Gly Asp 
        275                 280                 285             


Ser Lys Val Ser Cys Ser Asp Asn Leu Asn Gln Val Tyr Ile Asp Ile 
    290                 295                 300                 


Ser Asn Ile Pro Thr Thr Glu Asp Glu Phe Leu Leu Cys Tyr Tyr Ser 
305                 310                 315                 320 


Asn Ser Leu Arg Ser Val Val Gly Ile Ser Arg Pro Phe Gln Ile Pro 
                325                 330                 335     


Pro Gly Ser Leu Arg Glu Asp Pro Leu Gly Glu Ala Gln Pro Gln Ile 
            340                 345                 350         


<210> 8879
<211> 124
<212> PRT
<213> Homo sapiens

<400> 8879
Met Thr Gly Ser Cys Cys Gly Ser Thr Phe Ser Ser Leu Ser Tyr Gly 
1               5                   10                  15      


Gly Gly Cys Cys Gln Pro Cys Cys Cys Arg Asp Pro Cys Cys Cys Arg 
            20                  25                  30          


Pro Val Thr Cys Gln Thr Thr Val Cys Arg Pro Val Thr Cys Val Pro 
        35                  40                  45              


Arg Cys Thr Arg Pro Ile Cys Glu Pro Cys Arg Arg Pro Val Cys Cys 
    50                  55                  60                  


Asp Pro Cys Ser Leu Gln Glu Gly Cys Cys Arg Pro Ile Thr Cys Cys 
65                  70                  75                  80  


Pro Ser Ser Cys Thr Ala Val Val Cys Arg Pro Cys Cys Trp Ala Thr 
                85                  90                  95      


Thr Cys Cys Gln Pro Pro Val Ser Val Gln Ser Pro Cys Gly Gln Pro 
            100                 105                 110         


Thr Pro Cys Ser Thr Thr Cys Arg Thr Ser Ser Cys 
        115                 120                 


<210> 8880
<211> 308
<212> PRT
<213> Homo sapiens

<400> 8880
Met Lys Arg Ala His Pro Glu Tyr Ser Ser Ser Asp Ser Glu Leu Asp 
1               5                   10                  15      


Glu Thr Ile Glu Val Glu Lys Glu Ser Ala Asp Glu Asn Gly Asn Leu 
            20                  25                  30          


Ser Ser Ala Leu Gly Ser Met Ser Pro Thr Thr Ser Ser Gln Ile Leu 
        35                  40                  45              


Ala Arg Lys Arg Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg 
    50                  55                  60                  


Ile Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Ser Ala Phe 
65                  70                  75                  80  


Glu Lys Gln Val Met Glu Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu 
                85                  90                  95      


Ile Leu Gln Met Thr Val Asp His Leu Lys Met Leu His Thr Ala Gly 
            100                 105                 110         


Gly Lys Gly Tyr Phe Asp Ala His Ala Leu Ala Met Asp Tyr Arg Ser 
        115                 120                 125             


Leu Gly Phe Arg Glu Cys Leu Ala Glu Val Ala Arg Tyr Leu Ser Ile 
    130                 135                 140                 


Ile Glu Gly Leu Asp Ala Ser Asp Pro Leu Arg Val Arg Leu Val Ser 
145                 150                 155                 160 


His Leu Asn Asn Tyr Ala Ser Gln Arg Glu Ala Ala Ser Gly Ala His 
                165                 170                 175     


Ala Gly Leu Gly His Ile Pro Trp Gly Thr Val Phe Gly His His Pro 
            180                 185                 190         


His Ile Ala His Pro Leu Leu Leu Pro Gln Asn Gly His Gly Asn Ala 
        195                 200                 205             


Gly Thr Thr Ala Ser Pro Thr Glu Pro His His Gln Gly Arg Leu Gly 
    210                 215                 220                 


Ser Ala His Pro Glu Ala Pro Ala Leu Arg Ala Pro Pro Ser Gly Ser 
225                 230                 235                 240 


Leu Gly Pro Val Leu Pro Val Val Thr Ser Ala Ser Lys Leu Ser Pro 
                245                 250                 255     


Pro Leu Leu Ser Ser Val Ala Ser Leu Ser Ala Phe Pro Phe Ser Phe 
            260                 265                 270         


Gly Ser Phe His Leu Leu Ser Pro Asn Ala Leu Ser Pro Ser Ala Pro 
        275                 280                 285             


Thr Gln Ala Ala Asn Leu Gly Lys Pro Tyr Arg Pro Trp Gly Thr Glu 
    290                 295                 300                 


Ile Gly Ala Phe 
305             


<210> 8881
<211> 980
<212> PRT
<213> Homo sapiens

<400> 8881
Met Thr Glu Gly Arg His Cys Gln Val His Leu Leu Asp Asp Arg Arg 
1               5                   10                  15      


Leu Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Arg Glu Leu Leu Asp 
            20                  25                  30          


Leu Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile 
        35                  40                  45              


Thr Phe Ile Asp Asp Thr Gly Gln Gln Asn Trp Leu Gln Leu Asp His 
    50                  55                  60                  


Arg Val Leu Asp His Asp Leu Pro Lys Lys Pro Gly Pro Thr Ile Leu 
65                  70                  75                  80  


His Phe Ala Val Arg Phe Tyr Ile Glu Ser Ile Ser Phe Leu Lys Asp 
                85                  90                  95      


Lys Thr Thr Val Glu Leu Phe Phe Leu Asn Ala Lys Ala Cys Val His 
            100                 105                 110         


Lys Gly Gln Ile Glu Val Glu Ser Glu Thr Ile Phe Lys Leu Ala Ala 
        115                 120                 125             


Phe Ile Leu Gln Ser Pro Lys Val Ser Leu Thr His Asp Glu Asn Ala 
    130                 135                 140                 


Arg Lys Asp Leu Lys Thr Leu Pro Ala Phe Pro Thr Lys Thr Leu Gln 
145                 150                 155                 160 


Glu His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr 
                165                 170                 175     


Leu Lys Ile Lys Gly Leu Thr Arg Gly Gln Ala Val Val Gln Tyr Met 
            180                 185                 190         


Lys Ile Val Glu Ala Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val 
        195                 200                 205             


Lys Asp Lys Gln Gly Leu Pro Trp Trp Leu Gly Ile Ser Tyr Lys Gly 
    210                 215                 220                 


Ile Gly Gln Tyr Asp Ile Gln Asp Lys Val Lys Pro Arg Lys Leu Phe 
225                 230                 235                 240 


Gln Trp Lys Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ala 
                245                 250                 255     


Val Glu Val His Asp Pro Arg Arg Ile Ser Val Ser Arg Arg Thr Phe 
            260                 265                 270         


Gly Gln Ser Gly Leu Phe Val Gln Thr Trp Tyr Ala Asn Ser Ser Leu 
        275                 280                 285             


Ile Lys Ser Ile Trp Val Met Ala Ile Ser Gln His Gln Phe Tyr Leu 
    290                 295                 300                 


Asp Arg Lys Gln Ser Lys Ala Lys Ile Pro Ser Ala Arg Ser Leu Asp 
305                 310                 315                 320 


Glu Ile Ala Met Asp Leu Thr Glu Thr Gly Thr Gln Arg Ala Ser Lys 
                325                 330                 335     


Leu Val Thr Leu Glu Thr Lys Ser Gln Phe Ile Met Ala Ser Asn Gly 
            340                 345                 350         


Ser Leu Ile Ser Ser Gly Ser Gln Asp Ser Glu Val Ser Glu Glu Gln 
        355                 360                 365             


Lys Arg Glu Lys Ile Leu Glu Leu Lys Lys Lys Glu Lys Leu Leu Gln 
    370                 375                 380                 


Glu Lys Leu Leu Lys Lys Val Glu Glu Leu Lys Lys Ile Cys Leu Arg 
385                 390                 395                 400 


Glu Ala Glu Leu Thr Gly Lys Met Pro Lys Glu Tyr Pro Leu Asn Ile 
                405                 410                 415     


Gly Glu Lys Pro Pro Gln Val Arg Arg Arg Val Gly Thr Ala Phe Lys 
            420                 425                 430         


Leu Asp Asp Asn Leu Leu Pro Ser Glu Glu Asp Pro Ala Leu Gln Glu 
        435                 440                 445             


Leu Glu Ser Asn Phe Leu Ile Gln Gln Lys Leu Val Glu Ala Ala Lys 
    450                 455                 460                 


Lys Leu Ala Asn Glu Pro Asp Leu Cys Lys Thr Val Lys Lys Lys Arg 
465                 470                 475                 480 


Lys Gln Asp Tyr Thr Asp Ala Met Lys Lys Leu Gln Glu Ile Glu Asn 
                485                 490                 495     


Ala Ile Asn Glu Tyr Arg Ile Arg Cys Gly Lys Lys Pro Ser Gln Lys 
            500                 505                 510         


Ala Thr Val Leu Pro Glu Asp Ile Ile Pro Ser Glu Ser Ser Ser Leu 
        515                 520                 525             


Ser Asp Thr Thr Thr Tyr Asp Asp Pro Ser Asp Ala Phe Thr Phe Pro 
    530                 535                 540                 


Gly Gln Arg Ser Ser Ser Val Pro His Ser Pro Arg Ile Leu Pro Pro 
545                 550                 555                 560 


Lys Ser Leu Gly Ile Glu Arg Ile His Phe Arg Lys Ser Ser Ile Asn 
                565                 570                 575     


Glu Gln Phe Val Asp Thr Arg Gln Ser Arg Glu Met Leu Ser Thr His 
            580                 585                 590         


Ser Ser Pro Tyr Lys Thr Leu Glu Arg Arg Pro Gln Gly Gly Arg Ser 
        595                 600                 605             


Met Pro Thr Thr Pro Val Leu Thr Arg Asn Ala Tyr Ser Ser Ser His 
    610                 615                 620                 


Leu Glu Pro Glu Ser Ser Ser Gln His Cys Arg Gln Arg Ser Gly Ser 
625                 630                 635                 640 


Leu Glu Ser Gln Ser His Leu Leu Ser Glu Met Asp Ser Asp Lys Pro 
                645                 650                 655     


Phe Phe Ser Leu Ser Lys Ser Gln Arg Ser Ser Ser Thr Glu Ile Leu 
            660                 665                 670         


Asp Asp Gly Ser Ser Tyr Thr Ser Gln Ser Ser Thr Glu Tyr Tyr Cys 
        675                 680                 685             


Val Thr Pro Val Thr Gly Pro Tyr Tyr Thr Thr Gln Thr Leu Asp Thr 
    690                 695                 700                 


Arg Thr Arg Gly Arg Arg Arg Ser Lys Lys Gln Asn Val Ser Thr Ser 
705                 710                 715                 720 


Asn Ser Gly Ser Met Pro Asn Leu Ala Gln Lys Asp Ser Leu Arg Asn 
                725                 730                 735     


Gly Val Tyr Ser Lys Ser Gln Glu Pro Pro Ser Ser Ser Tyr Tyr Ile 
            740                 745                 750         


Ala Gly Tyr Thr Pro Tyr Ala Glu Cys Asp Phe Tyr Tyr Ser Gly Gly 
        755                 760                 765             


Tyr Val Tyr Glu Asn Asp Thr Glu Gly Gln Tyr Ser Val Asn Pro Ser 
    770                 775                 780                 


Tyr Arg Ser Ser Ala His Tyr Gly Tyr Glu Arg Gln Arg Asp Tyr Ser 
785                 790                 795                 800 


Arg Ser Phe His Glu Asp Glu Val Asp Arg Val Pro His Asn Pro Tyr 
                805                 810                 815     


Ala Thr Leu Arg Leu Pro Arg Lys Ala Ala Ala Lys Ser Glu His Ile 
            820                 825                 830         


Thr Lys Asn Ile His Lys Ala Leu Val Ala Glu His Leu Arg Gly Trp 
        835                 840                 845             


Tyr Gln Arg Ala Ser Gly Gln Lys Asp Gln Gly His Ser Pro Gln Thr 
    850                 855                 860                 


Ser Phe Asp Ser Asp Arg Gly Ser Gln Arg Cys Leu Gly Phe Ala Gly 
865                 870                 875                 880 


Leu Gln Val Pro Cys Ser Pro Ser Ser Arg Ala Ser Ser Tyr Ser Ser 
                885                 890                 895     


Val Ser Ser Thr Asn Ala Ser Gly Asn Trp Arg Thr Gln Leu Thr Ile 
            900                 905                 910         


Gly Leu Ser Asp Tyr Glu Thr Pro Ala His Ser Ser Tyr Thr Ser Cys 
        915                 920                 925             


Tyr Gly Asn Val Tyr Asn Pro Leu Pro Ser Pro Ser Arg Gln Tyr Thr 
    930                 935                 940                 


Glu Ile Ser Gln Leu Asp Gly Thr Asp Gly Asn Gln Leu Glu Asp Asn 
945                 950                 955                 960 


Leu Glu Ser Ser Glu Gln Arg Leu Phe Trp His Glu Asp Ser Lys Pro 
                965                 970                 975     


Gly Thr Leu Val 
            980 


<210> 8882
<211> 992
<212> PRT
<213> Homo sapiens

<400> 8882
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Ile Gly Gln Val Lys Gln Glu Leu Ser 
        435                 440                 445             


Arg Lys Asp Thr Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu 
    450                 455                 460                 


Thr Asn Gln Phe Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Thr Ala Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val 
                485                 490                 495     


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
            500                 505                 510         


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
        515                 520                 525             


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
    530                 535                 540                 


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
545                 550                 555                 560 


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
                565                 570                 575     


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
            580                 585                 590         


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
        595                 600                 605             


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
    610                 615                 620                 


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
625                 630                 635                 640 


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
                645                 650                 655     


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
            660                 665                 670         


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
        675                 680                 685             


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
    690                 695                 700                 


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
705                 710                 715                 720 


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
                725                 730                 735     


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
            740                 745                 750         


Glu Leu Glu Ser Leu Thr Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
        755                 760                 765             


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
    770                 775                 780                 


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
785                 790                 795                 800 


Ser Gln Gln Leu Gln Asp Ser Leu Arg Lys Lys Asp Asp Arg Ile Glu 
                805                 810                 815     


Glu Leu Glu Glu Ala Leu Arg Glu Ser Val Gln Ile Thr Ala Glu Arg 
            820                 825                 830         


Glu Met Val Leu Ala Gln Glu Glu Ser Ala Arg Thr Asn Ala Glu Lys 
        835                 840                 845             


Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val Lys Gln Glu Leu 
    850                 855                 860                 


Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln Ser Leu Ala Glu 
865                 870                 875                 880 


Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg Arg Lys His Leu 
                885                 890                 895     


Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser 
            900                 905                 910         


Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser Ser Ser Lys Lys 
        915                 920                 925             


Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu Lys Asp Arg Leu 
    930                 935                 940                 


Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala 
945                 950                 955                 960 


Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His Ser Asn Gln Thr 
                965                 970                 975     


Asn His Lys Pro Ser Pro Asp Gln Asp Glu Glu Glu Gly Ile Trp Ala 
            980                 985                 990         


<210> 8883
<211> 1045
<212> PRT
<213> Homo sapiens

<400> 8883
Met Leu Thr Val Gln Val Lys Thr Ser Ser Ala Ile Glu Leu Pro Asp 
1               5                   10                  15      


Ser Leu Ala Phe Leu Trp Ile Ile Pro Met Trp Tyr Cys Glu Gly Lys 
            20                  25                  30          


Glu Leu Glu Asn Ser Pro Asp Ile His Ile Val Gln Ala Gly Asn Leu 
        35                  40                  45              


His Ser Leu Thr Ile Ala Glu Ala Phe Glu Glu Asp Thr Gly Arg Tyr 
    50                  55                  60                  


Ser Cys Phe Ala Ser Asn Ile Tyr Gly Thr Asp Ser Thr Ser Ala Glu 
65                  70                  75                  80  


Ile Tyr Ile Glu Gly Val Ser Ser Ser Asp Ser Glu Gly Asp Pro Asn 
                85                  90                  95      


Lys Glu Glu Met Asn Arg Ile Gln Lys Pro Asn Glu Val Ser Ser Pro 
            100                 105                 110         


Pro Thr Thr Ser Ala Val Ile Pro Pro Ala Val Pro Gln Ala Gln His 
        115                 120                 125             


Leu Val Ala Gln Pro Arg Val Ala Thr Ile Gln Gln Cys Gln Ser Pro 
    130                 135                 140                 


Thr Asn Tyr Leu Gln Gly Leu Asp Gly Lys Pro Ile Ile Ala Ala Pro 
145                 150                 155                 160 


Val Phe Thr Lys Met Leu Gln Asn Leu Ser Ala Ser Glu Gly Gln Leu 
                165                 170                 175     


Val Val Phe Glu Cys Arg Val Lys Gly Ala Pro Ser Pro Lys Val Glu 
            180                 185                 190         


Trp Tyr Arg Glu Gly Thr Leu Ile Glu Asp Ser Pro Asp Phe Arg Ile 
        195                 200                 205             


Leu Gln Lys Arg Pro Val Cys Met Glu His Ile Glu Glu Ile Cys Thr 
    210                 215                 220                 


Leu Val Ile Ala Glu Val Phe Ala Glu Asp Ser Gly Cys Phe Thr Cys 
225                 230                 235                 240 


Thr Ala Ser Asn Lys Tyr Gly Thr Val Ser Ser Ile Ala Gln Leu His 
                245                 250                 255     


Val Arg Gly Asn Glu Asp Leu Ser Asn Asn Gly Ser Leu His Ser Ala 
            260                 265                 270         


Asn Ser Thr Thr Asn Leu Ala Ala Ile Glu Pro Gln Pro Ser Pro Pro 
        275                 280                 285             


His Ser Glu Pro Pro Ser Val Glu Gln Pro Pro Lys Pro Lys Leu Glu 
    290                 295                 300                 


Gly Val Leu Val Asn His Asn Glu Pro Arg Ser Ser Ser Arg Ile Gly 
305                 310                 315                 320 


Leu Arg Val His Phe Asn Leu Pro Glu Asp Asp Lys Gly Ser Glu Ala 
                325                 330                 335     


Ser Ser Glu Ala Gly Val Val Thr Thr Arg Gln Thr Arg Pro Asp Ser 
            340                 345                 350         


Phe Gln Glu Arg Phe Asn Gly Gln Ala Thr Lys Thr Pro Glu Pro Ser 
        355                 360                 365             


Ser Pro Val Lys Glu Pro Pro Pro Val Leu Ala Lys Pro Lys Leu Asp 
    370                 375                 380                 


Ser Thr Gln Leu Gln Gln Leu His Asn Gln Val Leu Leu Glu Gln His 
385                 390                 395                 400 


Gln Leu Gln Asn Pro Pro Pro Ser Ser Pro Lys Glu Phe Pro Phe Ser 
                405                 410                 415     


Met Thr Val Leu Asn Ser Asn Ala Pro Pro Ala Val Thr Thr Ser Ser 
            420                 425                 430         


Lys Gln Val Lys Ala Pro Ser Ser Gln Thr Phe Ser Leu Ala Arg Pro 
        435                 440                 445             


Lys Tyr Phe Phe Pro Ser Thr Asn Thr Thr Ala Ala Thr Val Ala Pro 
    450                 455                 460                 


Ser Ser Ser Pro Val Phe Thr Leu Ser Ser Thr Pro Gln Thr Ile Gln 
465                 470                 475                 480 


Arg Thr Val Ser Lys Glu Ser Leu Leu Val Ser His Pro Ser Val Gln 
                485                 490                 495     


Thr Lys Ser Pro Gly Gly Leu Ser Ile Gln Asn Glu Pro Leu Pro Pro 
            500                 505                 510         


Gly Pro Thr Glu Pro Thr Pro Pro Pro Phe Thr Phe Ser Ile Pro Ser 
        515                 520                 525             


Gly Asn Gln Phe Gln Pro Arg Cys Val Ser Pro Ile Pro Val Ser Pro 
    530                 535                 540                 


Thr Ser Arg Ile Gln Asn Pro Val Ala Phe Leu Ser Ser Val Leu Pro 
545                 550                 555                 560 


Ser Leu Pro Ala Ile Pro Pro Thr Asn Ala Met Gly Leu Pro Arg Ser 
                565                 570                 575     


Ala Pro Ser Met Pro Ser Gln Gly Leu Ala Lys Lys Asn Thr Lys Ser 
            580                 585                 590         


Pro Gln Pro Val Asn Asp Asp Asn Ile Arg Glu Thr Lys Asn Ala Val 
        595                 600                 605             


Ile Arg Asp Leu Gly Lys Lys Ile Thr Phe Ser Asp Val Arg Pro Asn 
    610                 615                 620                 


Gln Gln Glu Tyr Lys Ile Ser Ser Phe Glu Gln Arg Leu Met Asn Glu 
625                 630                 635                 640 


Ile Glu Phe Arg Leu Glu Arg Thr Pro Val Asp Glu Ser Asp Asp Glu 
                645                 650                 655     


Ile Gln His Asp Glu Ile Pro Thr Gly Lys Cys Ile Ala Pro Ile Phe 
            660                 665                 670         


Asp Lys Arg Leu Lys His Phe Arg Val Thr Glu Gly Ser Pro Val Thr 
        675                 680                 685             


Phe Thr Cys Lys Ile Val Gly Ile Pro Val Pro Lys Val Tyr Trp Phe 
    690                 695                 700                 


Lys Asp Gly Lys Gln Ile Ser Lys Arg Asn Glu His Cys Lys Met Arg 
705                 710                 715                 720 


Arg Glu Gly Asp Gly Thr Cys Ser Leu His Ile Glu Ser Thr Thr Ser 
                725                 730                 735     


Asp Asp Asp Gly Asn Tyr Thr Ile Met Ala Ala Asn Pro Gln Gly Arg 
            740                 745                 750         


Ile Ser Cys Ser Gly His Leu Met Val Gln Ser Leu Pro Ile Arg Ser 
        755                 760                 765             


Arg Leu Thr Ser Ala Gly Gln Ser His Arg Gly Arg Ser Arg Val Gln 
    770                 775                 780                 


Glu Arg Asp Lys Glu Pro Leu Gln Glu Arg Phe Phe Arg Pro His Phe 
785                 790                 795                 800 


Leu Gln Ala Pro Gly Asp Met Val Ala His Glu Gly Arg Leu Cys Arg 
                805                 810                 815     


Leu Asp Cys Lys Val Ser Gly Leu Pro Pro Pro Glu Leu Thr Trp Leu 
            820                 825                 830         


Leu Asn Gly Gln Pro Val Leu Pro Asp Ala Ser His Lys Met Leu Val 
        835                 840                 845             


Arg Glu Thr Gly Val His Ser Leu Leu Ile Asp Pro Leu Thr Gln Arg 
    850                 855                 860                 


Asp Ala Gly Thr Tyr Lys Cys Ile Ala Thr Asn Lys Thr Gly Gln Asn 
865                 870                 875                 880 


Ser Phe Ser Leu Glu Leu Ser Val Val Ala Lys Glu Val Lys Lys Ala 
                885                 890                 895     


Pro Val Ile Leu Glu Lys Leu Gln Asn Cys Gly Val Pro Glu Gly His 
            900                 905                 910         


Pro Val Arg Leu Glu Cys Arg Val Ile Gly Met Pro Pro Pro Val Phe 
        915                 920                 925             


Tyr Trp Lys Lys Asp Asn Glu Thr Ile Pro Cys Thr Arg Glu Arg Ile 
    930                 935                 940                 


Ser Met His Gln Asp Thr Thr Gly Tyr Ala Cys Leu Leu Ile Gln Pro 
945                 950                 955                 960 


Ala Lys Lys Ser Asp Ala Gly Trp Tyr Thr Leu Ser Ala Lys Asn Glu 
                965                 970                 975     


Ala Gly Ile Val Ser Cys Thr Ala Arg Leu Asp Ile Tyr Ala Gln Trp 
            980                 985                 990         


His His Gln Ile Pro Pro Pro Met  Ser Val Arg Pro Ser  Gly Ser Arg 
        995                 1000                 1005             


Tyr Gly  Ser Leu Thr Ser Lys  Gly Leu Asp Ile Phe  Ser Ala Phe 
    1010                 1015                 1020             


Ser Ser  Met Glu Ser Thr Met  Val Tyr Ser Cys Ser  Ser Arg Ser 
    1025                 1030                 1035             


Val Val  Glu Ser Asp Glu Leu  
    1040                 1045 


<210> 8884
<211> 23
<212> PRT
<213> Homo sapiens

<400> 8884
Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly Ser Phe His Thr 
1               5                   10                  15      


Ala Asp Pro Glu Gly Ala Ala 
            20              


<210> 8885
<211> 535
<212> PRT
<213> Homo sapiens

<400> 8885
Met Glu Ala Pro Thr Val Glu Thr Pro Pro Asp Pro Ser Pro Pro Ser 
1               5                   10                  15      


Ala Pro Ala Pro Ala Leu Val Pro Leu Arg Ala Pro Asp Val Ala Arg 
            20                  25                  30          


Leu Arg Glu Glu Gln Glu Lys Val Val Thr Asn Cys Gln Glu Arg Ile 
        35                  40                  45              


Gln His Trp Lys Lys Val Asp Asn Asp Tyr Asn Ala Leu Arg Glu Arg 
    50                  55                  60                  


Leu Ser Thr Leu Pro Asp Lys Leu Ser Tyr Asn Ile Met Val Pro Phe 
65                  70                  75                  80  


Gly Pro Phe Ala Phe Met Pro Gly Lys Leu Val His Thr Asn Glu Val 
                85                  90                  95      


Thr Val Leu Leu Gly Asp Asn Trp Phe Ala Lys Cys Ser Ala Lys Gln 
            100                 105                 110         


Ala Val Gly Leu Val Glu His Arg Lys Glu His Val Arg Lys Thr Ile 
        115                 120                 125             


Asp Asp Leu Lys Lys Val Met Lys Asn Phe Glu Ser Arg Val Glu Phe 
    130                 135                 140                 


Thr Glu Asp Leu Gln Lys Met Ser Asp Ala Ala Gly Asp Ile Val Asp 
145                 150                 155                 160 


Ile Arg Glu Glu Ile Lys Cys Asp Phe Glu Phe Lys Ala Lys His Arg 
                165                 170                 175     


Ile Ala His Lys Pro His Ser Lys Pro Lys Thr Ser Asp Ile Phe Glu 
            180                 185                 190         


Ala Asp Ile Ala Asn Asp Val Lys Ser Lys Asp Leu Leu Ala Asp Lys 
        195                 200                 205             


Glu Leu Trp Ala Arg Leu Glu Glu Leu Glu Arg Gln Glu Glu Leu Leu 
    210                 215                 220                 


Gly Glu Leu Asp Ser Lys Pro Asp Thr Val Ile Ala Asn Gly Glu Asp 
225                 230                 235                 240 


Thr Thr Ser Ser Glu Glu Glu Lys Glu Asp Arg Asn Thr Asn Val Asn 
                245                 250                 255     


Ala Met His Gln Val Thr Asp Ser His Thr Pro Cys His Lys Asp Val 
            260                 265                 270         


Ala Ser Ser Glu Pro Phe Ser Gly Gln Val Asn Ser Gln Leu Asn Cys 
        275                 280                 285             


Ser Val Asn Gly Ser Ser Ser Tyr His Ser Asp Asp Asp Asp Asp Asp 
    290                 295                 300                 


Asp Asp Asp Asp Asp Asp Asp Asn Ile Asp Asp Asp Asp Gly Asp Asn 
305                 310                 315                 320 


Asp His Glu Ala Leu Gly Val Gly Asp Asn Ser Ile Pro Thr Ile Tyr 
                325                 330                 335     


Phe Ser His Thr Val Glu Pro Lys Arg Val Arg Ile Asn Thr Gly Lys 
            340                 345                 350         


Asn Thr Thr Leu Lys Phe Ser Glu Lys Lys Glu Glu Ala Lys Arg Lys 
        355                 360                 365             


Arg Lys Asn Ser Thr Gly Ser Gly His Ser Ala Gln Glu Leu Pro Thr 
    370                 375                 380                 


Ile Arg Thr Pro Ala Asp Ile Tyr Arg Ala Phe Val Asp Val Val Asn 
385                 390                 395                 400 


Gly Glu Tyr Val Pro Arg Lys Ser Ile Leu Lys Ser Arg Ser Arg Glu 
                405                 410                 415     


Asn Ser Val Cys Ser Asp Thr Ser Glu Ser Ser Ala Ala Glu Phe Asp 
            420                 425                 430         


Asp Arg Arg Gly Val Leu Arg Ser Ile Ser Cys Glu Glu Ala Thr Cys 
        435                 440                 445             


Ser Asp Thr Ser Glu Ser Ile Leu Glu Glu Glu Pro Gln Glu Asn Gln 
    450                 455                 460                 


Lys Lys Leu Leu Pro Leu Ser Val Thr Pro Glu Ala Phe Ser Gly Thr 
465                 470                 475                 480 


Val Ile Glu Lys Glu Phe Val Ser Pro Ser Leu Thr Pro Pro Pro Ala 
                485                 490                 495     


Ile Ala His Pro Ala Leu Pro Thr Ile Pro Glu Arg Lys Glu Val Leu 
            500                 505                 510         


Leu Glu Ala Ser Glu Glu Thr Gly Lys Arg Val Ser Lys Phe Lys Ala 
        515                 520                 525             


Ala Arg Leu Gln Gln Lys Asp 
    530                 535 


<210> 8886
<211> 576
<212> PRT
<213> Homo sapiens

<400> 8886
Met Glu Gly Leu Arg Arg Arg Arg Gly Arg Glu Ala Gly Pro Pro Gln 
1               5                   10                  15      


Pro Met Val Pro Leu Ala Val Glu Asn Gln Ala Gly Gly Glu Gly Ala 
            20                  25                  30          


Gly Gly Glu Leu Gly Ile Ser Leu Asn Met Cys Leu Leu Gly Ala Leu 
        35                  40                  45              


Val Leu Leu Gly Leu Gly Val Leu Leu Phe Ser Gly Gly Leu Ser Glu 
    50                  55                  60                  


Ser Glu Thr Gly Pro Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp 
65                  70                  75                  80  


Pro Glu Val Leu Glu Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu 
                85                  90                  95      


Gln Leu Gln Ala Pro Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn 
            100                 105                 110         


Met Gly Leu Leu Leu Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg 
        115                 120                 125             


Leu Leu Gln Ala Gln Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu 
    130                 135                 140                 


Met His Gln Pro Lys Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly 
145                 150                 155                 160 


Ala Leu Gln Gln Gly Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu 
                165                 170                 175     


Gln Gln Leu Arg Ala Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg 
            180                 185                 190         


Gly Pro Asp Gly Val Cys Leu Ser Gly Gly Arg Gly Pro Gln Gly Asp 
        195                 200                 205             


Lys Ala Ile Arg Glu Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser 
    210                 215                 220                 


Phe Leu Lys Gln Lys Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg 
225                 230                 235                 240 


Gln Glu Leu Glu Arg Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp 
                245                 250                 255     


Leu Glu Arg Ser Leu Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala 
            260                 265                 270         


Gly Leu Ala Glu Leu Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu 
        275                 280                 285             


Glu Asn Trp Gly Gln Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala 
    290                 295                 300                 


Trp His Gln Lys Ser His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys 
305                 310                 315                 320 


Glu Lys Trp Trp Asp Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys 
                325                 330                 335     


His Lys Lys Glu Glu Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly 
            340                 345                 350         


Gln Glu Asp Arg Glu Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg 
        355                 360                 365             


Val Glu Glu Ser Gly Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys 
    370                 375                 380                 


Glu Pro Pro Arg Lys Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln 
385                 390                 395                 400 


Lys Gln Pro Arg Trp Arg Glu Gly Thr Lys Asp Ser His Asp Pro Leu 
                405                 410                 415     


Pro Ser Trp Ala Glu Leu Leu Arg Pro Lys Tyr Arg Ala Pro Gln Gly 
            420                 425                 430         


Cys Ser Gly Val Asp Glu Cys Ala Arg Gln Glu Gly Leu Thr Phe Phe 
        435                 440                 445             


Gly Thr Glu Leu Ala Pro Val Arg Gln Gln Glu Leu Ala Ser Leu Leu 
    450                 455                 460                 


Arg Thr Tyr Leu Ala Arg Leu Pro Trp Ala Gly Gln Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Pro Leu Ser Pro Ala Phe Phe Gly Glu Asp Gly Ile Phe Arg His 
                485                 490                 495     


Asp Arg Leu Arg Phe Arg Asp Phe Val Asp Ala Leu Glu Asp Ser Leu 
            500                 505                 510         


Glu Glu Val Ala Val Gln Gln Thr Gly Asp Asp Asp Glu Val Asp Asp 
        515                 520                 525             


Phe Glu Asp Phe Ile Phe Ser His Phe Phe Gly Asp Lys Ala Leu Lys 
    530                 535                 540                 


Lys Arg Ser Gly Lys Lys Asp Lys His Ser Gln Ser Pro Arg Ala Ala 
545                 550                 555                 560 


Gly Pro Arg Glu Gly His Ser His Ser His His His His His Arg Gly 
                565                 570                 575     


<210> 8887
<211> 747
<212> PRT
<213> Homo sapiens

<400> 8887
Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Val Val 
        435                 440                 445             


Ile Pro Leu Asp His Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Ser Thr Leu Gln 
625                 630                 635                 640 


Val Gln Glu Lys Ser Asn Thr Trp Ser Trp Gly Ile Leu Lys Met Leu 
                645                 650                 655     


Lys Gly Lys Asp Asp Arg Lys Lys Ser Ile Arg Glu Lys Pro Lys Val 
            660                 665                 670         


Ser Asp Ser Asp Asn Asn Glu Gly Ser Ser Phe Pro Ala Pro Pro Lys 
        675                 680                 685             


Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr Ser Asp 
    690                 695                 700                 


Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val Gly Lys 
705                 710                 715                 720 


Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln Glu Lys 
                725                 730                 735     


Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Lys 
            740                 745         


<210> 8888
<211> 521
<212> PRT
<213> Homo sapiens

<400> 8888
Met Thr Ser Ala Phe Lys Leu Asp Phe Leu Pro Asp Met Met Val Glu 
1               5                   10                  15      


Gly Arg Leu Leu Val Pro Asp Arg Ile Asn Gly Thr Ala Asn Lys Met 
            20                  25                  30          


Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile Lys 
        35                  40                  45              


Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu Lys 
    50                  55                  60                  


Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu Arg 
65                  70                  75                  80  


Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val Thr 
                85                  90                  95      


Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His Asn 
            100                 105                 110         


Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro Ala 
        115                 120                 125             


Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile Gly 
    130                 135                 140                 


Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe Ser 
145                 150                 155                 160 


Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp Gly 
                165                 170                 175     


Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met Ala 
            180                 185                 190         


Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly Cys 
        195                 200                 205             


Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys Glu 
    210                 215                 220                 


Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu Asn 
225                 230                 235                 240 


Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro Gln 
                245                 250                 255     


Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly Ala 
            260                 265                 270         


Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu Gln 
        275                 280                 285             


Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser Ala 
    290                 295                 300                 


Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu Gly 
305                 310                 315                 320 


Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala Gly 
                325                 330                 335     


Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu Ala 
            340                 345                 350         


Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Val Ala Gln 
        355                 360                 365             


Met Leu Ser Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr Gly 
    370                 375                 380                 


Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala Tyr 
385                 390                 395                 400 


Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr Ser 
                405                 410                 415     


Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu Gly 
            420                 425                 430         


Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly 
        435                 440                 445             


Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile Ser 
    450                 455                 460                 


Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly 
465                 470                 475                 480 


Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln Ala 
                485                 490                 495     


Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys 
            500                 505                 510         


Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
        515                 520     


<210> 8889
<211> 569
<212> PRT
<213> Homo sapiens

<400> 8889
Met Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp 
1               5                   10                  15      


Cys Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe 
            20                  25                  30          


Val Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His 
        35                  40                  45              


Arg Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu 
    50                  55                  60                  


Phe Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly 
65                  70                  75                  80  


Leu Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln 
                85                  90                  95      


Lys Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr 
            100                 105                 110         


Val Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile 
        115                 120                 125             


Ser Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro 
    130                 135                 140                 


Leu Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys 
145                 150                 155                 160 


Gly Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln 
                165                 170                 175     


Gln Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile 
            180                 185                 190         


Phe Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn 
        195                 200                 205             


Phe Ala His Phe Asn Ser His Ala Ala Gln Asn Ser Ala Asn Ala Asp 
    210                 215                 220                 


Phe Ala Asn Phe Asp Ala Phe Gly Gln Ser Ser Gly Ser Ser Asn Phe 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ala Ser His Ser Pro Phe Gln Pro Gln Thr Thr 
                245                 250                 255     


Ala Phe Arg Met Leu Ser Ser Ser Cys Ser Phe Gly Glu Phe Thr Ser 
            260                 265                 270         


Ala Phe Pro Leu Gln Ala Thr His Ser Gly Ser Ala Ala Ser Val Asn 
        275                 280                 285             


Ala Asn Phe Ala His Phe Asp Asn Phe Pro Lys Ser Ser Ser Ala Asp 
    290                 295                 300                 


Phe Gly Thr Phe Asn Thr Ser Gln Ser His Gln Thr Ala Ser Ala Val 
305                 310                 315                 320 


Ser Lys Val Ser Thr Asn Lys Ala Gly Leu Gln Thr Ala Asp Lys Tyr 
                325                 330                 335     


Ala Ala Leu Ala Asn Leu Asp Asn Ile Phe Ser Ala Gly Gln Gly Gly 
            340                 345                 350         


Asp Gln Gly Ser Gly Phe Gly Thr Thr Gly Lys Ala Pro Val Gly Ser 
        355                 360                 365             


Val Val Ser Val Pro Ser Gln Ser Ser Ala Ser Ser Asp Lys Tyr Ala 
    370                 375                 380                 


Ala Leu Ala Glu Leu Asp Ser Val Phe Ser Ser Ala Ala Thr Ser Ser 
385                 390                 395                 400 


Asn Ala Tyr Thr Ser Thr Ser Asn Ala Ser Ser Asn Val Phe Gly Thr 
                405                 410                 415     


Val Pro Val Val Ala Ser Ala Gln Thr Gln Pro Ala Ser Ser Ser Val 
            420                 425                 430         


Pro Ala Pro Phe Gly Ala Thr Pro Ser Thr Asn Pro Phe Val Ala Ala 
        435                 440                 445             


Ala Gly Pro Ser Val Ala Ser Ser Thr Asn Pro Phe Gln Thr Asn Ala 
    450                 455                 460                 


Arg Gly Ala Thr Ala Ala Thr Phe Gly Thr Ala Ser Met Ser Met Pro 
465                 470                 475                 480 


Thr Gly Phe Gly Thr Pro Ala Pro Tyr Ser Leu Pro Thr Ser Phe Ser 
                485                 490                 495     


Gly Ser Phe Gln Gln Pro Ala Phe Pro Ala Gln Ala Ala Phe Pro Gln 
            500                 505                 510         


Gln Thr Ala Phe Ser Gln Gln Pro Asn Gly Phe Ala Ala Phe Gly Gln 
        515                 520                 525             


Thr Lys Pro Val Val Thr Pro Phe Gly Gln Val Ala Ala Ala Gly Val 
    530                 535                 540                 


Ser Ser Asn Pro Phe Met Thr Gly Ala Pro Thr Gly Gln Phe Pro Thr 
545                 550                 555                 560 


Gly Ser Ser Ser Thr Asn Pro Phe Leu 
                565                 


<210> 8890
<211> 668
<212> PRT
<213> Homo sapiens

<400> 8890
Met Ser Lys Leu Ala Ala Ala His Arg Gly Ala Ile Arg Ala Leu Gln 
1               5                   10                  15      


Met Phe Val Thr Gln Phe Thr Asp Arg Gly Glu His Pro Leu Pro Ala 
            20                  25                  30          


Arg Cys Lys Glu Leu Gly Ser Leu Ile Arg Gln Leu Ser Leu Cys Ser 
        35                  40                  45              


Val Lys Leu Asp Ala Asp Pro Ser Val Pro Asp Val Val Ile Asp Ile 
    50                  55                  60                  


Leu Gln Gln Ile Glu Ala Leu Glu Ser Leu Leu Glu Lys Lys Leu Ser 
65                  70                  75                  80  


Pro Lys Lys Val Lys Lys Cys Phe Ser Glu Ile Arg Ser Arg Phe Pro 
                85                  90                  95      


Ile Gly Ser Gln Lys Ala Leu Glu Arg Trp Pro Ser Thr Ser Pro Lys 
            100                 105                 110         


Gly Glu Arg Arg Pro Leu Thr Ala Lys Asp Thr Phe Pro Gln Glu Thr 
        115                 120                 125             


Ser Arg Pro Ser Val Ala Lys Gln Leu Leu Ala Asp Lys Tyr Gln Pro 
    130                 135                 140                 


Asp Thr Glu Leu Pro Glu Thr Gln Arg Leu Gln Ser Glu Leu Asp Val 
145                 150                 155                 160 


Leu Asp Ala Asp Ile Val Leu Glu Glu Gly Pro Phe Ile Leu Asp Gln 
                165                 170                 175     


Ser Ala Ser Phe Lys Asp Glu Val Leu Ala Val Ala Lys Thr Lys Ala 
            180                 185                 190         


Gly Lys Lys Lys Pro Val Thr Glu Asn Val Pro Phe Arg Lys Lys Asp 
        195                 200                 205             


Thr Leu Ala Pro Ala Arg Gln Gln Gly Leu Arg Lys Ala Glu Arg Gly 
    210                 215                 220                 


Arg Gln Ser Gln Pro His Ser Lys Ser Arg Val Gln Gln Thr Thr Val 
225                 230                 235                 240 


Ser Ser Arg Leu Lys Met Asn Arg Gln Pro Val Lys Asp Arg Lys Ala 
                245                 250                 255     


Pro Trp Ile Pro Pro Asn Pro Thr Ser Pro Pro Ala Ser Pro Lys Cys 
            260                 265                 270         


Ala Ala Trp Leu Lys Val Lys Thr Ser Pro Arg Asp Ala Thr Lys Glu 
        275                 280                 285             


Pro Leu Gln Gln Glu Asp Pro Gln Glu Glu Ser His Leu Thr Gly Ala 
    290                 295                 300                 


Val Glu His Glu Ala Ala Arg Leu Ala Trp Leu Asp Ala Glu Thr Ser 
305                 310                 315                 320 


Lys Arg Leu Lys Glu Leu Glu Glu Leu Lys Ala Lys Glu Ile Asp Ser 
                325                 330                 335     


Met Gln Lys Gln Arg Leu Asp Trp Leu Asp Ala Glu Thr Ser Arg Arg 
            340                 345                 350         


Thr Lys Glu Leu Asn Glu Leu Lys Ala Glu Glu Met Tyr Arg Leu Gln 
        355                 360                 365             


Gln Leu Ser Val Ser Ala Thr His Leu Ala Asp Lys Val Glu Glu Ala 
    370                 375                 380                 


Val Leu Asp Arg Leu Lys Pro Leu Leu Val Lys Ala Gln Arg Val Asn 
385                 390                 395                 400 


Ser Thr Thr Glu Ala Asn Ile His Leu Lys Asp Gly Ser Ser Val Asn 
                405                 410                 415     


Thr Ala Lys Ala Gln Pro Ala Gln Glu Val Ala Ala Val Asp Phe Glu 
            420                 425                 430         


Ser Asn Asn Ile Arg Gln Leu Asp Asp Phe Leu Glu Asp Cys Ala Ser 
        435                 440                 445             


Glu Leu Trp Ala Val Thr His Ala Lys Ile Leu Gly Ser Glu Thr Leu 
    450                 455                 460                 


Ala Thr Val Glu Asp Ser Lys Asp Ser Pro Asp Leu Glu Ile Met Met 
465                 470                 475                 480 


Arg Arg Met Glu Glu Met Glu Lys Tyr Gln Glu Ser Val Arg Gln Arg 
                485                 490                 495     


Tyr Asn Lys Ile Ala Tyr Ala Asp Pro Arg Leu Trp Met Gln Glu Glu 
            500                 505                 510         


Asn Asn Asp Gln Lys Ile Ser Ala Ile Ser Glu Lys Pro Leu Ser Pro 
        515                 520                 525             


His Pro Ile Arg Ile Thr Lys Thr Val Asp Arg Lys Asp Pro Ala Val 
    530                 535                 540                 


Asn Ile Met Leu Glu Arg Pro Cys Asn Gly Asn Ser Leu Asp Glu Ser 
545                 550                 555                 560 


Val Gly Thr Glu Glu Gly Ser Glu Lys Arg Glu Ala Pro Leu Leu Ser 
                565                 570                 575     


Leu Ala Glu Asp Ser Gln Gln Lys Glu Gly Arg Ala Pro Leu Phe Val 
            580                 585                 590         


Pro Pro Gly Met Gln His Ser Ile Gly Asp Tyr Cys Ser Arg Phe Glu 
        595                 600                 605             


Gln Tyr Leu Arg Ile Ile Ser His Glu Ala Val Gly Ser Phe Asn Pro 
    610                 615                 620                 


Trp Leu Ile Ala Glu Ser Phe Ser Glu Glu Leu Val Asp Glu Ala Leu 
625                 630                 635                 640 


Gly Ala Val Ala Ala Glu Leu Gln Asp Met Cys Glu Asp Tyr Ala Glu 
                645                 650                 655     


Ala Val Phe Thr Ser Glu Phe Leu Glu Ala Ala Thr 
            660                 665             


<210> 8891
<211> 1203
<212> PRT
<213> Homo sapiens

<400> 8891
Met Pro Ala Arg Ile Gly Tyr Tyr Glu Ile Asp Arg Thr Ile Gly Lys 
1               5                   10                  15      


Gly Asn Phe Ala Val Val Lys Arg Ala Thr His Leu Val Thr Lys Ala 
            20                  25                  30          


Lys Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asp Glu Glu Asn 
        35                  40                  45              


Leu Lys Lys Ile Phe Arg Glu Val Gln Ile Met Lys Met Leu Cys His 
    50                  55                  60                  


Pro His Ile Ile Arg Leu Tyr Gln Val Met Glu Thr Glu Arg Met Ile 
65                  70                  75                  80  


Tyr Leu Val Thr Glu Tyr Ala Ser Gly Gly Glu Ile Phe Asp His Leu 
                85                  90                  95      


Val Ala His Gly Arg Met Ala Glu Lys Glu Ala Arg Arg Lys Phe Lys 
            100                 105                 110         


Gln Ile Val Thr Ala Val Tyr Phe Cys His Cys Arg Asn Ile Val His 
        115                 120                 125             


Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Asn Leu Asn Ile 
    130                 135                 140                 


Lys Ile Ala Asp Phe Gly Phe Ser Asn Leu Phe Thr Pro Gly Gln Leu 
145                 150                 155                 160 


Leu Lys Thr Trp Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe 
                165                 170                 175     


Glu Gly Lys Glu Tyr Asp Gly Pro Lys Val Asp Ile Trp Ser Leu Gly 
            180                 185                 190         


Val Val Leu Tyr Val Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Ser 
        195                 200                 205             


Thr Leu Gln Asn Leu Arg Ala Arg Val Leu Ser Gly Lys Phe Arg Ile 
    210                 215                 220                 


Pro Phe Phe Met Ser Thr Glu Cys Glu His Leu Ile Arg His Met Leu 
225                 230                 235                 240 


Val Leu Asp Pro Asn Lys Arg Leu Ser Met Glu Gln Ile Cys Lys His 
                245                 250                 255     


Lys Trp Met Lys Leu Gly Asp Ala Asp Pro Asn Phe Asp Arg Leu Ile 
            260                 265                 270         


Ala Glu Cys Gln Gln Leu Lys Glu Glu Arg Gln Val Asp Pro Leu Asn 
        275                 280                 285             


Glu Asp Val Leu Leu Ala Met Glu Asp Met Gly Leu Asp Lys Glu Gln 
    290                 295                 300                 


Thr Leu Gln Ala Glu Gln Ala Gly Thr Ala Met Asn Ile Ser Val Pro 
305                 310                 315                 320 


Gln Val Gln Leu Ile Asn Pro Glu Asn Gln Ile Val Glu Pro Asp Gly 
                325                 330                 335     


Thr Leu Asn Leu Asp Ser Asp Glu Gly Glu Glu Pro Ser Pro Glu Ala 
            340                 345                 350         


Leu Val Arg Tyr Leu Ser Met Arg Arg His Thr Val Gly Val Ala Asp 
        355                 360                 365             


Pro Arg Thr Glu Val Met Glu Asp Leu Gln Lys Leu Leu Pro Gly Phe 
    370                 375                 380                 


Pro Gly Val Asn Pro Gln Ala Pro Phe Leu Gln Val Ala Pro Asn Val 
385                 390                 395                 400 


Asn Phe Met His Asn Leu Leu Pro Met Gln Asn Leu Gln Pro Thr Gly 
                405                 410                 415     


Gln Leu Glu Tyr Lys Glu Gln Ser Leu Leu Gln Pro Pro Thr Leu Gln 
            420                 425                 430         


Leu Leu Asn Gly Met Gly Pro Leu Gly Arg Arg Ala Ser Asp Gly Gly 
        435                 440                 445             


Ala Asn Ile Gln Leu His Ala Gln Gln Leu Leu Lys Arg Pro Arg Gly 
    450                 455                 460                 


Pro Ser Pro Leu Val Thr Met Thr Pro Ala Val Pro Ala Val Thr Pro 
465                 470                 475                 480 


Val Asp Glu Glu Ser Ser Asp Gly Glu Pro Asp Gln Glu Ala Val Gln 
                485                 490                 495     


Arg Tyr Leu Ala Asn Arg Ser Lys Arg His Thr Leu Ala Met Thr Asn 
            500                 505                 510         


Pro Thr Ala Glu Ile Pro Pro Asp Leu Gln Arg Gln Leu Gly Gln Gln 
        515                 520                 525             


Pro Phe Arg Ser Arg Val Trp Pro Pro His Leu Val Pro Asp Gln His 
    530                 535                 540                 


Arg Ser Thr Tyr Lys Asp Ser Asn Thr Leu His Leu Pro Thr Glu Arg 
545                 550                 555                 560 


Phe Ser Pro Val Arg Arg Phe Ser Asp Gly Ala Ala Ser Ile Gln Ala 
                565                 570                 575     


Phe Lys Ala His Leu Glu Lys Met Gly Asn Asn Ser Ser Ile Lys Gln 
            580                 585                 590         


Leu Gln Gln Glu Cys Glu Gln Leu Gln Lys Met Tyr Gly Gly Gln Ile 
        595                 600                 605             


Asp Glu Arg Thr Leu Glu Lys Thr Gln Gln Gln His Met Leu Tyr Gln 
    610                 615                 620                 


Gln Glu Gln His His Gln Ile Leu Gln Gln Gln Ile Gln Asp Ser Ile 
625                 630                 635                 640 


Cys Pro Pro Gln Pro Ser Pro Pro Leu Gln Ala Ala Cys Glu Asn Gln 
                645                 650                 655     


Pro Ala Leu Leu Thr His Gln Leu Gln Arg Leu Arg Ile Gln Pro Ser 
            660                 665                 670         


Ser Pro Pro Pro Asn His Pro Asn Asn His Leu Phe Arg Gln Pro Ser 
        675                 680                 685             


Asn Ser Pro Pro Pro Met Ser Ser Ala Met Ile Gln Pro His Gly Ala 
    690                 695                 700                 


Ala Ser Ser Ser Gln Phe Gln Gly Leu Pro Ser Arg Ser Ala Ile Phe 
705                 710                 715                 720 


Gln Gln Gln Pro Glu Asn Cys Ser Ser Pro Pro Asn Val Ala Leu Thr 
                725                 730                 735     


Cys Leu Gly Met Gln Gln Pro Ala Gln Ser Gln Gln Val Thr Ile Gln 
            740                 745                 750         


Val Gln Glu Pro Val Asp Met Leu Ser Asn Met Pro Gly Thr Ala Ala 
        755                 760                 765             


Gly Ser Ser Gly Arg Gly Ile Ser Ile Ser Pro Ser Ala Gly Gln Met 
    770                 775                 780                 


Gln Met Gln His Arg Thr Asn Leu Met Ala Thr Leu Ser Tyr Gly His 
785                 790                 795                 800 


Arg Pro Leu Ser Lys Gln Leu Ser Ala Asp Ser Ala Glu Ala His Ser 
                805                 810                 815     


Ala His Gln Gln Pro Pro His Tyr Thr Thr Ser Ala Leu Gln Gln Ala 
            820                 825                 830         


Leu Leu Ser Pro Thr Pro Pro Asp Tyr Thr Arg His Gln Gln Val Pro 
        835                 840                 845             


His Ile Leu Gln Gly Leu Leu Ser Pro Arg His Ser Leu Thr Gly His 
    850                 855                 860                 


Ser Asp Ile Arg Leu Pro Pro Thr Glu Phe Ala Gln Leu Ile Lys Arg 
865                 870                 875                 880 


Gln Gln Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
                885                 890                 895     


Tyr Gln Glu Leu Phe Arg His Met Asn Gln Gly Asp Ala Gly Ser Leu 
            900                 905                 910         


Ala Pro Ser Leu Gly Gly Gln Ser Met Thr Glu Arg Gln Ala Leu Ser 
        915                 920                 925             


Tyr Gln Asn Ala Asp Ser Tyr His His His Thr Ser Pro Gln His Leu 
    930                 935                 940                 


Leu Gln Ile Arg Ala Gln Glu Cys Val Ser Gln Ala Ser Ser Pro Thr 
945                 950                 955                 960 


Pro Pro His Gly Tyr Ala His Gln Pro Ala Leu Met His Ser Glu Ser 
                965                 970                 975     


Met Glu Glu Asp Cys Ser Cys Glu Gly Ala Lys Asp Gly Phe Gln Asp 
            980                 985                 990         


Ser Lys Ser Ser Ser Thr Leu Thr  Lys Gly Cys His Asp  Ser Pro Leu 
        995                 1000                 1005             


Leu Leu  Ser Thr Gly Gly Pro  Gly Asp Pro Glu Ser  Leu Leu Gly 
    1010                 1015                 1020             


Thr Val  Ser His Ala Gln Glu  Leu Gly Ile His Pro  Tyr Gly His 
    1025                 1030                 1035             


Gln Pro  Thr Ala Ala Phe Ser  Lys Asn Lys Val Pro  Ser Arg Glu 
    1040                 1045                 1050             


Pro Val  Ile Gly Asn Cys Met  Asp Arg Ser Ser Pro  Gly Gln Ala 
    1055                 1060                 1065             


Val Glu  Leu Pro Asp His Asn  Gly Leu Gly Tyr Pro  Ala Arg Pro 
    1070                 1075                 1080             


Ser Val  His Glu His His Arg  Pro Arg Ala Leu Gln  Arg His His 
    1085                 1090                 1095             


Thr Ile  Gln Asn Ser Asp Asp  Ala Tyr Val Gln Leu  Asp Asn Leu 
    1100                 1105                 1110             


Pro Gly  Met Ser Leu Val Ala  Gly Lys Ala Leu Ser  Ser Ala Arg 
    1115                 1120                 1125             


Met Ser  Asp Ala Val Leu Ser  Gln Ser Ser Leu Met  Gly Ser Gln 
    1130                 1135                 1140             


Gln Phe  Gln Asp Gly Glu Asn  Glu Glu Cys Gly Ala  Ser Leu Gly 
    1145                 1150                 1155             


Gly His  Glu His Pro Asp Leu  Ser Asp Gly Ser Gln  His Leu Asn 
    1160                 1165                 1170             


Ser Ser  Cys Tyr Pro Ser Thr  Cys Ile Thr Asp Ile  Leu Leu Ser 
    1175                 1180                 1185             


Tyr Lys  His Pro Glu Val Ser  Phe Ser Met Glu Gln  Ala Gly Val 
    1190                 1195                 1200             


<210> 8892
<211> 681
<212> PRT
<213> Homo sapiens

<400> 8892
Met Ile Glu Lys Met Gln Gly Ser Arg Met Asp Glu Gln Arg Cys Ser 
1               5                   10                  15      


Phe Pro Pro Pro Leu Lys Thr Glu Glu Asp Tyr Ile Pro Tyr Pro Ser 
            20                  25                  30          


Val His Glu Val Leu Gly Arg Glu Gly Pro Phe Pro Leu Ile Leu Leu 
        35                  40                  45              


Pro Gln Phe Gly Gly Tyr Trp Ile Glu Gly Thr Asn His Glu Ile Thr 
    50                  55                  60                  


Ser Ile Pro Glu Thr Glu Pro Leu Gln Ser Pro Thr Thr Lys Val Lys 
65                  70                  75                  80  


Leu Glu Cys Asn Pro Thr Ala Arg Ile Tyr Arg Lys His Phe Leu Gly 
                85                  90                  95      


Lys Glu His Phe Asn Tyr Tyr Ser Leu Asp Ala Ala Leu Gly His Leu 
            100                 105                 110         


Val Phe Ser Leu Lys Tyr Asp Val Ile Gly Asp Gln Glu His Leu Arg 
        115                 120                 125             


Leu Leu Leu Arg Thr Lys Cys Arg Thr Tyr His Asp Val Ile Pro Ile 
    130                 135                 140                 


Ser Cys Leu Thr Glu Phe Pro Asn Val Val Gln Met Ala Lys Leu Val 
145                 150                 155                 160 


Cys Glu Asp Val Asn Val Asp Arg Phe Tyr Pro Val Leu Tyr Pro Lys 
                165                 170                 175     


Ala Ser Arg Leu Ile Val Thr Phe Asp Glu His Val Ile Ser Asn Asn 
            180                 185                 190         


Phe Lys Phe Gly Val Ile Tyr Gln Lys Leu Gly Gln Thr Ser Glu Glu 
        195                 200                 205             


Glu Leu Phe Ser Thr Asn Glu Glu Ser Pro Ala Phe Val Glu Phe Leu 
    210                 215                 220                 


Glu Phe Leu Gly Gln Lys Val Lys Leu Gln Asp Phe Lys Gly Phe Arg 
225                 230                 235                 240 


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Thr Glu Ser Val Tyr 
                245                 250                 255     


Cys Asn Phe Arg Asn Lys Glu Ile Met Phe His Val Ser Thr Lys Leu 
            260                 265                 270         


Pro Tyr Thr Glu Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
        275                 280                 285             


Gly Asn Asp Ile Val Ala Val Val Phe Gln Asp Glu Asn Thr Pro Phe 
    290                 295                 300                 


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Val Val Val 
305                 310                 315                 320 


Gln Ala Glu Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val 
                325                 330                 335     


Thr Ala Arg Asp Asp Val Pro Phe Phe Gly Pro Pro Leu Pro Asp Pro 
            340                 345                 350         


Ala Val Phe Arg Lys Gly Pro Glu Phe Gln Glu Phe Leu Leu Thr Lys 
        355                 360                 365             


Leu Ile Asn Ala Glu Tyr Ala Cys Tyr Lys Ala Glu Lys Phe Ala Lys 
    370                 375                 380                 


Leu Glu Glu Arg Thr Arg Ala Ala Leu Leu Glu Thr Leu Tyr Glu Glu 
385                 390                 395                 400 


Leu His Ile His Ser Gln Ser Met Met Gly Leu Gly Gly Asp Glu Asp 
                405                 410                 415     


Lys Met Glu Asn Gly Ser Gly Gly Gly Gly Phe Phe Glu Ser Phe Lys 
            420                 425                 430         


Arg Val Ile Arg Ser Arg Ser Gln Ser Met Asp Ala Met Gly Leu Ser 
        435                 440                 445             


Asn Lys Lys Pro Asn Thr Val Ser Thr Ser His Ser Gly Ser Phe Ala 
    450                 455                 460                 


Pro Asn Asn Pro Asp Leu Ala Lys Ala Ala Gly Ile Ser Leu Leu Ile 
465                 470                 475                 480 


Pro Gly Lys Ser Ala Ser Arg Phe Gly Arg Arg Gly Ser Ala Ile Gly 
                485                 490                 495     


Ile Gly Thr Val Glu Glu Ser Leu Ile Val Pro Gly Lys Ser Pro Thr 
            500                 505                 510         


Arg Lys Lys Ser Gly Pro Phe Gly Ser Arg Arg Ser Ser Ala Ile Gly 
        515                 520                 525             


Ile Glu Asn Ile Gln Glu Val Gln Glu Lys Arg Glu Ser Pro Pro Ala 
    530                 535                 540                 


Gly Gln Lys Thr Pro Asp Ser Gly His Val Ser Gln Glu Pro Lys Ser 
545                 550                 555                 560 


Glu Asn Ser Ser Thr Gln Ser Ser Pro Glu Met Pro Thr Thr Lys Asn 
                565                 570                 575     


Arg Ala Glu Thr Ala Ala Gln Arg Ala Glu Ala Leu Lys Asp Phe Ser 
            580                 585                 590         


Arg Ser Ser Ser Ser Ala Ser Ser Phe Ala Ser Val Val Glu Glu Thr 
        595                 600                 605             


Glu Gly Val Asp Gly Glu Asp Thr Gly Leu Glu Ser Val Ser Ser Ser 
    610                 615                 620                 


Gly Thr Pro His Lys Arg Asp Ser Phe Ile Tyr Ser Thr Trp Leu Glu 
625                 630                 635                 640 


Asp Ser Val Ser Thr Thr Ser Gly Gly Ser Ser Pro Asp Ala Gly Lys 
                645                 650                 655     


Leu Gly Asp Pro Ala Cys Pro Glu Ile Lys Ile Gln Leu Glu Ala Ser 
            660                 665                 670         


Glu Gln His Met Pro Gln Leu Gly Cys 
        675                 680     


<210> 8893
<211> 224
<212> PRT
<213> Homo sapiens

<400> 8893
Met Ser Val Gly Tyr Ala Asn Gly Ile Arg Val Met Ser Met Thr His 
1               5                   10                  15      


Thr Gly Glu Pro Gly Phe Met Leu Tyr Ile Pro Ile Glu Tyr Ala Leu 
            20                  25                  30          


His Val Tyr Asn Glu Val Met Ser Val Gly Gln Lys Tyr Gly Ile Arg 
        35                  40                  45              


Asn Ala Gly Tyr Tyr Ala Leu Arg Ser Leu Arg Ile Glu Lys Phe Phe 
    50                  55                  60                  


Ala Phe Trp Gly Gln Asp Ile Asn Asn Leu Thr Thr Pro Leu Glu Cys 
65                  70                  75                  80  


Gly Arg Glu Ser Arg Val Lys Leu Glu Lys Gly Met Asp Phe Ile Gly 
                85                  90                  95      


Arg Asp Ala Leu Leu Gln Gln Lys Gln Asn Gly Val Tyr Lys Arg Leu 
            100                 105                 110         


Thr Met Phe Ile Leu Asp Asp His Asp Ser Asp Leu Asp Leu Trp Pro 
        115                 120                 125             


Trp Trp Gly Glu Pro Ile Tyr Arg Asn Gly Gln Tyr Val Gly Lys Thr 
    130                 135                 140                 


Thr Ser Ser Ala Tyr Ser Tyr Ser Leu Glu Arg His Val Cys Leu Gly 
145                 150                 155                 160 


Phe Val His Asn Phe Ser Glu Asp Thr Gly Glu Glu Gln Val Val Thr 
                165                 170                 175     


Ala Asp Phe Ile Asn Arg Gly Glu Tyr Glu Ile Asp Ile Ala Gly Tyr 
            180                 185                 190         


Arg Phe Gln Ala Lys Ala Lys Leu Tyr Pro Val Ala Ser Leu Phe Thr 
        195                 200                 205             


Gln Lys Arg Arg Lys Asp Asp Met Glu Leu Ser Asp Leu His Gly Lys 
    210                 215                 220                 


<210> 8894
<211> 529
<212> PRT
<213> Homo sapiens

<400> 8894
Met His Phe Ser Gly Leu Glu Glu Ala Val Tyr Arg Asn Ile Gln Ala 
1               5                   10                  15      


Cys Lys Glu Leu Ala Gln Thr Thr Arg Thr Ala Tyr Gly Pro Asn Gly 
            20                  25                  30          


Met Asn Lys Met Val Ile Asn His Leu Glu Lys Leu Phe Val Thr Asn 
        35                  40                  45              


Asp Ala Ala Thr Ile Leu Arg Glu Leu Glu Val Gln His Pro Ala Ala 
    50                  55                  60                  


Lys Met Ile Val Met Ala Ser His Met Gln Glu Gln Glu Val Gly Asp 
65                  70                  75                  80  


Gly Thr Asn Phe Val Leu Val Phe Ala Gly Ala Leu Leu Glu Leu Ala 
                85                  90                  95      


Glu Glu Leu Leu Arg Ile Gly Leu Ser Val Ser Glu Val Ile Glu Gly 
            100                 105                 110         


Tyr Glu Ile Ala Cys Arg Lys Ala His Glu Ile Leu Pro Asn Leu Val 
        115                 120                 125             


Cys Cys Ser Ala Lys Asn Leu Arg Asp Ile Asp Glu Val Ser Ser Leu 
    130                 135                 140                 


Leu Arg Thr Ser Ile Met Ser Lys Gln Tyr Gly Asn Glu Val Phe Leu 
145                 150                 155                 160 


Ala Lys Leu Ile Ala Gln Ala Cys Val Ser Ile Phe Pro Asp Ser Gly 
                165                 170                 175     


His Phe Asn Val Asp Asn Ile Arg Val Cys Lys Ile Leu Gly Ser Gly 
            180                 185                 190         


Ile Ser Ser Ser Ser Val Leu His Gly Met Val Phe Lys Lys Glu Thr 
        195                 200                 205             


Glu Gly Asp Val Thr Ser Val Lys Asp Ala Lys Ile Ala Val Tyr Ser 
    210                 215                 220                 


Cys Pro Phe Asp Gly Met Ile Thr Glu Thr Lys Gly Thr Val Leu Ile 
225                 230                 235                 240 


Lys Thr Ala Glu Glu Leu Met Asn Phe Ser Lys Gly Glu Glu Asn Leu 
                245                 250                 255     


Met Asp Ala Gln Val Lys Ala Ile Ala Asp Thr Gly Ala Asn Val Val 
            260                 265                 270         


Val Thr Gly Gly Lys Val Ala Asp Met Ala Leu His Tyr Ala Asn Lys 
        275                 280                 285             


Tyr Asn Ile Met Leu Val Arg Leu Asn Ser Lys Trp Asp Leu Arg Arg 
    290                 295                 300                 


Leu Cys Lys Thr Val Gly Ala Thr Ala Leu Pro Arg Leu Thr Pro Pro 
305                 310                 315                 320 


Val Leu Glu Glu Met Gly His Cys Asp Ser Val Tyr Leu Ser Glu Val 
                325                 330                 335     


Gly Asp Thr Gln Val Val Val Phe Lys His Glu Lys Glu Asp Gly Ala 
            340                 345                 350         


Ile Ser Thr Ile Val Leu Arg Gly Ser Thr Asp Asn Leu Met Asp Asp 
        355                 360                 365             


Ile Glu Arg Ala Val Asp Asp Gly Val Asn Thr Phe Lys Val Leu Thr 
    370                 375                 380                 


Arg Asp Lys Arg Leu Val Pro Gly Gly Gly Ala Thr Glu Ile Glu Leu 
385                 390                 395                 400 


Ala Lys Gln Ile Thr Ser Tyr Gly Glu Thr Cys Pro Gly Leu Glu Gln 
                405                 410                 415     


Tyr Ala Ile Lys Lys Phe Ala Glu Ala Phe Glu Ala Ile Pro Arg Ala 
            420                 425                 430         


Leu Ala Glu Asn Ser Gly Val Lys Ala Asn Glu Val Ile Ser Lys Leu 
        435                 440                 445             


Tyr Ala Val His Gln Glu Gly Asn Lys Asn Val Gly Leu Asp Ile Glu 
    450                 455                 460                 


Ala Glu Val Pro Ala Val Lys Asp Met Leu Glu Ala Gly Ile Leu Asp 
465                 470                 475                 480 


Thr Tyr Leu Gly Lys Tyr Trp Ala Ile Lys Leu Ala Thr Asn Ala Ala 
                485                 490                 495     


Val Thr Val Leu Arg Val Asp Gln Ile Ile Met Ala Lys Pro Ala Gly 
            500                 505                 510         


Gly Pro Lys Pro Pro Ser Gly Lys Lys Asp Trp Asp Asp Asp Gln Asn 
        515                 520                 525             


Asp 
    


<210> 8895
<211> 730
<212> PRT
<213> Homo sapiens

<400> 8895
Met Phe Gly Arg Lys Arg Ser Val Ser Phe Gly Gly Phe Gly Trp Ile 
1               5                   10                  15      


Asp Lys Thr Met Leu Ala Ser Leu Lys Val Lys Lys Gln Glu Leu Ala 
            20                  25                  30          


Asn Ser Ser Asp Ala Thr Leu Pro Asp Arg Pro Leu Ser Pro Pro Leu 
        35                  40                  45              


Thr Ala Pro Pro Thr Met Lys Ser Ser Glu Phe Phe Glu Met Leu Glu 
    50                  55                  60                  


Lys Met Gln Gly Ile Lys Leu Glu Glu Gln Lys Pro Gly Pro Gln Lys 
65                  70                  75                  80  


Asn Lys Asp Asp Tyr Ile Pro Tyr Pro Ser Ile Asp Glu Val Val Glu 
                85                  90                  95      


Lys Gly Gly Pro Tyr Pro Gln Val Ile Leu Pro Gln Phe Gly Gly Tyr 
            100                 105                 110         


Trp Ile Glu Asp Pro Glu Asn Val Gly Thr Pro Thr Ser Leu Gly Ser 
        115                 120                 125             


Ser Ile Cys Glu Glu Glu Glu Glu Asp Asn Leu Ser Pro Asn Thr Phe 
    130                 135                 140                 


Gly Tyr Lys Leu Glu Cys Lys Gly Glu Ala Arg Ala Tyr Arg Arg His 
145                 150                 155                 160 


Phe Leu Gly Lys Asp His Leu Asn Phe Tyr Cys Thr Gly Ser Ser Leu 
                165                 170                 175     


Gly Asn Leu Ile Leu Ser Val Lys Cys Glu Glu Ala Glu Gly Ile Glu 
            180                 185                 190         


Tyr Leu Arg Val Ile Leu Arg Ser Lys Leu Lys Thr Val His Glu Arg 
        195                 200                 205             


Ile Pro Leu Ala Gly Leu Ser Lys Leu Pro Ser Val Pro Gln Ile Ala 
    210                 215                 220                 


Lys Ala Phe Cys Asp Asp Ala Val Gly Leu Arg Phe Asn Pro Val Leu 
225                 230                 235                 240 


Tyr Pro Lys Ala Ser Gln Met Ile Val Ser Tyr Asp Glu His Glu Val 
                245                 250                 255     


Asn Asn Thr Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala Arg Gln Thr 
            260                 265                 270         


Leu Glu Glu Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro Ala Phe Lys 
        275                 280                 285             


Glu Phe Leu Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln Asp Phe Lys 
    290                 295                 300                 


Gly Phe Arg Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Val Glu 
305                 310                 315                 320 


Ser Val Tyr Thr Thr Phe Arg Asp Arg Glu Ile Met Phe His Val Ser 
                325                 330                 335     


Thr Lys Leu Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu Gln Arg Lys 
            340                 345                 350         


Arg His Ile Gly Asn Asp Ile Val Ala Ile Ile Phe Gln Glu Glu Asn 
        355                 360                 365             


Thr Pro Phe Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr 
    370                 375                 380                 


Ile Val Val Gln Val Glu Thr Pro Gly Thr Glu Thr Pro Ser Tyr Lys 
385                 390                 395                 400 


Val Ser Val Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro Pro Leu 
                405                 410                 415     


Pro Ser Pro Pro Val Phe Gln Lys Gly Pro Glu Phe Arg Glu Phe Leu 
            420                 425                 430         


Leu Thr Lys Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser Asp Lys 
        435                 440                 445             


Phe Ala Lys Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp Asn Leu 
    450                 455                 460                 


His Asp Glu Leu His Ala His Thr Gln Ala Met Leu Gly Leu Gly Pro 
465                 470                 475                 480 


Glu Glu Asp Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu Glu Ser 
                485                 490                 495     


Phe Lys Arg Ala Ile Arg Val Arg Ser His Ser Met Glu Thr Met Val 
            500                 505                 510         


Gly Gly Gln Lys Lys Ser His Ser Gly Gly Ile Pro Gly Ser Leu Ser 
        515                 520                 525             


Gly Gly Ile Ser His Asn Ser Met Glu Val Thr Lys Thr Thr Phe Ser 
    530                 535                 540                 


Pro Pro Val Val Ala Ala Thr Val Lys Asn Gln Ser Arg Ser Pro Ile 
545                 550                 555                 560 


Lys Arg Arg Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser Glu Gly 
                565                 570                 575     


Gln Gly Asp Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr Pro Lys 
            580                 585                 590         


Thr Pro Asp Gly Gly His Ser Ser Gln Glu Ile Lys Ser Glu Thr Ser 
        595                 600                 605             


Ser Asn Pro Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu Lys Pro Phe 
    610                 615                 620                 


Met Lys Leu Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser Ser Ser Ser 
625                 630                 635                 640 


Thr Ser Ser Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met Glu Glu 
                645                 650                 655     


Gly Asp Ser Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro Phe Lys Gln 
            660                 665                 670         


Glu Val Phe Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro Ser Leu 
        675                 680                 685             


Gly Ala Ala Ala Thr Pro Ile Ile Met Ser Arg Ser Pro Thr Asp Ala 
    690                 695                 700                 


Lys Ser Arg Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe Asp Lys 
705                 710                 715                 720 


Leu Ser His Ala Ser Ser Gly Ala Gly His 
                725                 730 


<210> 8896
<211> 756
<212> PRT
<213> Homo sapiens

<400> 8896
Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg 
145                 150                 155                 160 


Ile His Ile Phe Ala Gln Gln Asn Asp Gln Phe Gln Lys Val Leu Ser 
                165                 170                 175     


Leu Cys Gly His Glu Asp Trp Ile Arg Gly Val Glu Trp Ala Ala Phe 
            180                 185                 190         


Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg 
        195                 200                 205             


Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp 
    210                 215                 220                 


Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser 
225                 230                 235                 240 


Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val Leu Ala Gly His 
                245                 250                 255     


Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val Phe Tyr Lys Asp 
            260                 265                 270         


Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala Ser Met Asp Lys 
        275                 280                 285             


Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly Val Trp Leu Glu 
    290                 295                 300                 


Gln Arg Glu Trp Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp Gly 
305                 310                 315                 320 


Val Gln Asp Leu Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr Val 
                325                 330                 335     


Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys Asp 
            340                 345                 350         


Gln Ser Gln Val Thr Trp His Glu Ile Ala Arg Pro Gln Ile His Gly 
        355                 360                 365             


Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val Ser 
    370                 375                 380                 


Gly Ala Asp Glu Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn Phe 
385                 390                 395                 400 


Val Glu Asn Phe Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val Leu 
                405                 410                 415     


Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala Leu 
            420                 425                 430         


Gly Leu Ser Asn Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln Pro 
        435                 440                 445             


Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln Gln 
    450                 455                 460                 


Val Ala Phe Gln Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp His 
465                 470                 475                 480 


Leu Leu Gln Asn Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly His 
                485                 490                 495     


Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu Leu 
            500                 505                 510         


Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile Leu 
        515                 520                 525             


Trp Asn Thr Thr Ser Trp Lys Gln Val Gln Asn Leu Val Phe His Ser 
    530                 535                 540                 


Leu Thr Val Thr Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu Leu 
545                 550                 555                 560 


Ala Val Ser Arg Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp Thr 
                565                 570                 575     


Ile Ser Pro Glu Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr Asn 
            580                 585                 590         


Lys Ile Thr Ser Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp Ser 
        595                 600                 605             


Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val Val 
    610                 615                 620                 


Val Trp Gly Glu Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn Ile 
625                 630                 635                 640 


Gly Pro Cys Ser Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala Val 
                645                 650                 655     


Ser Val Cys Pro Val Leu His Pro Ser Gln Arg Tyr Val Val Ala Val 
            660                 665                 670         


Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr Asp 
        675                 680                 685             


Gln Val Pro Glu Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser Gln 
    690                 695                 700                 


Ser Gln Ser His Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn Cys 
705                 710                 715                 720 


Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu His 
                725                 730                 735     


Phe Ala Ser Cys Gly Glu Asp His Thr Val Lys Ile His Arg Val Asn 
            740                 745                 750         


Lys Cys Ala Leu 
        755     


<210> 8897
<211> 423
<212> PRT
<213> Homo sapiens

<400> 8897
Met Asn Arg Gln Pro Val Lys Asp Arg Lys Ala Pro Trp Ile Pro Pro 
1               5                   10                  15      


Asn Pro Thr Ser Pro Pro Ala Ser Pro Lys Cys Ala Ala Trp Leu Lys 
            20                  25                  30          


Val Lys Thr Ser Pro Arg Asp Ala Thr Lys Glu Pro Leu Gln Gln Glu 
        35                  40                  45              


Asp Pro Gln Glu Glu Ser His Leu Thr Gly Ala Val Glu His Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ala Trp Leu Asp Ala Glu Thr Ser Lys Arg Leu Lys Glu 
65                  70                  75                  80  


Leu Glu Glu Leu Lys Ala Lys Glu Ile Asp Ser Met Gln Lys Gln Arg 
                85                  90                  95      


Leu Asp Trp Leu Asp Ala Glu Thr Ser Arg Arg Thr Lys Glu Leu Asn 
            100                 105                 110         


Glu Leu Lys Ala Glu Glu Met Tyr Arg Leu Gln Gln Leu Ser Val Ser 
        115                 120                 125             


Ala Thr His Leu Ala Asp Lys Val Glu Glu Ala Val Leu Asp Arg Leu 
    130                 135                 140                 


Lys Pro Leu Leu Val Lys Ala Gln Arg Val Asn Ser Thr Thr Glu Ala 
145                 150                 155                 160 


Asn Ile His Leu Lys Asp Gly Ser Ser Val Asn Thr Ala Lys Ala Gln 
                165                 170                 175     


Pro Ala Gln Glu Val Ala Ala Val Asp Phe Glu Ser Asn Asn Ile Arg 
            180                 185                 190         


Gln Leu Asp Asp Phe Leu Glu Asp Cys Ala Ser Glu Leu Trp Ala Val 
        195                 200                 205             


Thr His Ala Lys Ile Leu Gly Ser Glu Thr Leu Ala Thr Val Glu Asp 
    210                 215                 220                 


Ser Lys Asp Ser Pro Asp Leu Glu Ile Met Met Arg Arg Met Glu Glu 
225                 230                 235                 240 


Met Glu Lys Tyr Gln Glu Ser Val Arg Gln Arg Tyr Asn Lys Ile Ala 
                245                 250                 255     


Tyr Ala Asp Pro Arg Leu Trp Met Gln Glu Glu Asn Asn Asp Gln Lys 
            260                 265                 270         


Ile Ser Ala Ile Ser Glu Lys Pro Leu Ser Pro His Pro Ile Arg Ile 
        275                 280                 285             


Thr Lys Thr Val Asp Arg Lys Asp Pro Ala Val Asn Ile Met Leu Glu 
    290                 295                 300                 


Arg Pro Cys Asn Gly Asn Ser Leu Asp Glu Ser Val Gly Thr Glu Glu 
305                 310                 315                 320 


Gly Ser Glu Lys Arg Glu Ala Pro Leu Leu Ser Leu Ala Glu Asp Ser 
                325                 330                 335     


Gln Gln Lys Glu Gly Arg Ala Pro Leu Phe Val Pro Pro Gly Met Gln 
            340                 345                 350         


His Ser Ile Gly Asp Tyr Cys Ser Arg Phe Glu Gln Tyr Leu Arg Ile 
        355                 360                 365             


Ile Ser His Glu Ala Val Gly Ser Phe Asn Pro Trp Leu Ile Ala Glu 
    370                 375                 380                 


Ser Phe Ser Glu Glu Leu Val Asp Glu Ala Leu Gly Ala Val Ala Ala 
385                 390                 395                 400 


Glu Leu Gln Asp Met Cys Glu Asp Tyr Ala Glu Ala Val Phe Thr Ser 
                405                 410                 415     


Glu Phe Leu Glu Ala Ala Thr 
            420             


<210> 8898
<211> 258
<212> PRT
<213> Homo sapiens

<400> 8898
Met Ala Arg Leu Gln Glu Glu His Gly Asp Gln Leu Leu Ser Ile Arg 
1               5                   10                  15      


Cys Gln His Gln Glu Gln Val Glu Asp Leu Thr Ala Ser His Asp Ala 
            20                  25                  30          


Ala Leu Leu Glu Met Glu Asn Asn His Thr Val Ala Ile Thr Ile Leu 
        35                  40                  45              


Gln Asp Asp His Asp His Lys Val Gln Glu Leu Met Ser Thr His Glu 
    50                  55                  60                  


Leu Glu Lys Lys Glu Leu Glu Glu Asn Phe Glu Lys Leu Arg Leu Ser 
65                  70                  75                  80  


Leu Gln Asp Gln Val Asp Thr Leu Thr Phe Gln Ser Gln Ser Leu Arg 
                85                  90                  95      


Asp Arg Ala Arg Arg Phe Glu Glu Ala Leu Arg Lys Asn Thr Glu Glu 
            100                 105                 110         


Gln Leu Glu Ile Ala Leu Ala Pro Tyr Gln His Leu Glu Glu Asp Met 
        115                 120                 125             


Lys Ser Leu Lys Gln Val Leu Glu Met Lys Asn Gln Gln Ile His Glu 
    130                 135                 140                 


Gln Glu Lys Lys Ile Leu Glu Leu Glu Lys Leu Ala Glu Lys Asn Ile 
145                 150                 155                 160 


Ile Leu Glu Glu Lys Ile Gln Val Leu Gln Gln Gln Asn Glu Asp Leu 
                165                 170                 175     


Lys Ala Arg Ile Asp Gln Asn Thr Val Val Thr Arg Gln Leu Ser Glu 
            180                 185                 190         


Glu Asn Ala Asn Leu Gln Glu Tyr Val Glu Lys Glu Thr Gln Glu Lys 
        195                 200                 205             


Lys Arg Leu Ser Arg Thr Asn Glu Glu Leu Leu Trp Lys Leu Gln Thr 
    210                 215                 220                 


Gly Asp Pro Thr Ser Pro Ile Lys Leu Ser Pro Thr Ser Pro Val Tyr 
225                 230                 235                 240 


Arg Gly Ser Ser Ser Gly Pro Ser Ser Pro Ala Arg Val Ser Thr Thr 
                245                 250                 255     


Pro Arg 
        


<210> 8899
<211> 350
<212> PRT
<213> Homo sapiens

<400> 8899
Met Cys Pro Thr Thr Thr Trp Pro Arg Gly Arg Arg Trp Ser Arg Asn 
1               5                   10                  15      


Leu Arg Asp Thr Gln Ala Val Arg His Tyr Lys Ile Trp Arg Arg Ala 
            20                  25                  30          


Gly Gly Arg Leu His Leu Asn Glu Ala Val Ser Phe Leu Ser Leu Pro 
        35                  40                  45              


Glu Leu Val Asn Tyr His Arg Ala Gln Ser Leu Ser His Gly Leu Arg 
    50                  55                  60                  


Leu Ala Ala Pro Cys Arg Lys His Glu Pro Glu Pro Leu Pro His Trp 
65                  70                  75                  80  


Asp Asp Trp Glu Arg Pro Arg Glu Glu Phe Thr Leu Cys Arg Lys Leu 
                85                  90                  95      


Gly Ser Gly Tyr Phe Gly Glu Val Phe Glu Gly Leu Trp Lys Asp Arg 
            100                 105                 110         


Val Gln Val Ala Ile Lys Val Ile Ser Arg Asp Asn Leu Leu His Gln 
        115                 120                 125             


Gln Met Leu Gln Ser Glu Ile Gln Ala Met Lys Lys Leu Arg His Lys 
    130                 135                 140                 


His Ile Leu Ala Leu Tyr Ala Val Val Ser Val Gly Asp Pro Val Tyr 
145                 150                 155                 160 


Ile Ile Thr Glu Leu Met Ala Lys Gly Ser Leu Leu Glu Leu Leu Arg 
                165                 170                 175     


Asp Ser Asp Glu Lys Val Leu Pro Val Ser Glu Leu Leu Asp Ile Ala 
            180                 185                 190         


Trp Gln Val Ala Glu Gly Met Cys Tyr Leu Glu Ser Gln Asn Tyr Ile 
        195                 200                 205             


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Thr Leu 
    210                 215                 220                 


Cys Lys Val Gly Asp Phe Gly Leu Ala Arg Leu Ile Lys Glu Asp Val 
225                 230                 235                 240 


Tyr Leu Ser His Asp His Asn Ile Pro Tyr Lys Trp Thr Ala Pro Glu 
                245                 250                 255     


Ala Leu Ser Arg Gly His Tyr Ser Thr Lys Ser Asp Val Trp Ser Phe 
            260                 265                 270         


Gly Ile Leu Leu His Glu Met Phe Ser Arg Gly Gln Val Pro Tyr Pro 
        275                 280                 285             


Gly Met Ser Asn His Glu Ala Phe Leu Arg Val Asp Ala Gly Tyr Arg 
    290                 295                 300                 


Met Pro Cys Pro Leu Glu Cys Pro Pro Ser Val His Lys Leu Met Leu 
305                 310                 315                 320 


Thr Cys Trp Cys Arg Asp Pro Glu Gln Arg Pro Cys Phe Lys Ala Leu 
                325                 330                 335     


Arg Glu Arg Leu Ser Ser Phe Thr Ser Tyr Glu Asn Pro Thr 
            340                 345                 350 


<210> 8900
<211> 1159
<212> PRT
<213> Homo sapiens

<400> 8900
Met Val Ser Ser Ser Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro 
1               5                   10                  15      


Ser Gln Pro Ala Ala Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn 
            20                  25                  30          


Leu Thr Lys Thr Ala Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly 
        35                  40                  45              


Ser Ile Lys Lys Gly Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu 
    50                  55                  60                  


Val Gly Gly Thr Lys Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp 
65                  70                  75                  80  


Phe Ala Lys Gly Glu Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly 
                85                  90                  95      


Lys Asn Asp Gly Ala Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro 
            100                 105                 110         


Lys Tyr Gly Leu Phe Ala Pro Val His Lys Val Thr Lys Ile Gly Phe 
        115                 120                 125             


Pro Ser Thr Thr Pro Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val 
    130                 135                 140                 


Met Ala Thr Thr Ser Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser 
145                 150                 155                 160 


Leu Ser Ser Met Ser Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser 
                165                 170                 175     


Arg Thr Gly Leu Leu Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile 
            180                 185                 190         


Ser Gly Thr Thr Ala Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His 
        195                 200                 205             


Ile Glu Gln Leu Leu Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala 
    210                 215                 220                 


Lys Ala Thr Ser His Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala 
225                 230                 235                 240 


Arg Asp Gly His Asp Gln His Val Leu Glu Leu Glu Ala Lys Met Asp 
                245                 250                 255     


Gln Leu Arg Thr Met Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu 
            260                 265                 270         


Leu Asn Gln Leu Glu Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe 
        275                 280                 285             


Arg Val Glu Glu Glu Ser Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr 
    290                 295                 300                 


Lys Leu Glu His Ala Arg Ile Lys Glu Leu Glu Gln Ser Leu Leu Phe 
305                 310                 315                 320 


Glu Lys Thr Lys Ala Asp Lys Leu Gln Arg Glu Leu Glu Asp Thr Arg 
                325                 330                 335     


Val Ala Thr Val Ser Glu Lys Ser Arg Ile Met Glu Leu Glu Lys Asp 
            340                 345                 350         


Leu Ala Leu Arg Val Gln Glu Val Ala Glu Leu Arg Arg Arg Leu Glu 
        355                 360                 365             


Ser Asn Lys Pro Ala Gly Asp Val Asp Met Ser Leu Ser Leu Leu Gln 
    370                 375                 380                 


Glu Ile Ser Ser Leu Gln Glu Lys Leu Glu Val Thr Arg Thr Asp His 
385                 390                 395                 400 


Gln Arg Glu Ile Thr Ser Leu Lys Glu His Phe Gly Ala Arg Glu Glu 
                405                 410                 415     


Thr His Gln Lys Glu Ile Lys Ala Leu Tyr Thr Ala Thr Glu Lys Leu 
            420                 425                 430         


Ser Lys Glu Asn Glu Ser Leu Lys Ser Lys Leu Glu His Ala Asn Lys 
        435                 440                 445             


Glu Asn Ser Asp Val Ile Ala Leu Trp Lys Ser Lys Leu Glu Thr Ala 
    450                 455                 460                 


Ile Ala Ser His Gln Gln Ala Met Glu Glu Leu Lys Val Ser Phe Ser 
465                 470                 475                 480 


Lys Gly Leu Gly Thr Glu Thr Ala Glu Phe Ala Glu Leu Lys Thr Gln 
                485                 490                 495     


Ile Glu Lys Met Arg Leu Asp Tyr Gln His Glu Ile Glu Asn Leu Gln 
            500                 505                 510         


Asn Gln Gln Asp Ser Glu Arg Ala Ala His Ala Lys Glu Met Glu Ala 
        515                 520                 525             


Leu Arg Ala Lys Leu Met Lys Val Ile Lys Glu Lys Glu Asn Ser Leu 
    530                 535                 540                 


Glu Ala Ile Arg Ser Lys Leu Asp Lys Ala Glu Asp Gln His Leu Val 
545                 550                 555                 560 


Glu Met Glu Asp Thr Leu Asn Lys Leu Gln Glu Ala Glu Ile Lys Lys 
                565                 570                 575     


Glu Lys Phe Ala Glu Ala Ser Glu Glu Ala Val Ser Val Gln Arg Ser 
            580                 585                 590         


Met Gln Glu Thr Val Asn Lys Leu His Gln Lys Glu Glu Gln Phe Asn 
        595                 600                 605             


Met Leu Ser Ser Asp Leu Glu Lys Leu Arg Glu Asn Leu Ala Asp Met 
    610                 615                 620                 


Glu Ala Lys Phe Arg Glu Lys Asp Glu Arg Glu Glu Gln Leu Ile Lys 
625                 630                 635                 640 


Ala Lys Glu Lys Leu Glu Asn Asp Ile Ala Glu Ile Met Lys Met Ser 
                645                 650                 655     


Gly Asp Asn Ser Ser Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu 
            660                 665                 670         


Lys Glu Arg Asp Val Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn 
        675                 680                 685             


Glu Asn Ala Ser Phe Leu Gln Lys Ser Ile Glu Asp Met Thr Val Lys 
    690                 695                 700                 


Ala Glu Gln Ser Gln Gln Glu Ala Ala Lys Lys His Glu Glu Glu Lys 
705                 710                 715                 720 


Lys Glu Leu Glu Arg Lys Leu Ser Asp Leu Glu Lys Lys Met Glu Thr 
                725                 730                 735     


Ser His Asn Gln Cys Gln Glu Leu Lys Ala Arg Tyr Glu Arg Ala Thr 
            740                 745                 750         


Ser Glu Thr Lys Thr Lys His Glu Glu Ile Leu Gln Asn Leu Gln Lys 
        755                 760                 765             


Thr Leu Leu Asp Thr Glu Asp Lys Leu Lys Gly Ala Arg Glu Glu Asn 
    770                 775                 780                 


Ser Gly Leu Leu Gln Glu Leu Glu Glu Leu Arg Lys Gln Ala Asp Lys 
785                 790                 795                 800 


Ala Lys Ala Ala Gln Thr Ala Glu Asp Ala Met Gln Ile Met Glu Gln 
                805                 810                 815     


Met Thr Lys Glu Lys Thr Glu Thr Leu Ala Ser Leu Glu Asp Thr Lys 
            820                 825                 830         


Gln Thr Asn Ala Lys Leu Gln Asn Glu Leu Asp Thr Leu Lys Glu Asn 
        835                 840                 845             


Asn Leu Lys Asn Val Glu Glu Leu Asn Lys Ser Lys Glu Leu Leu Thr 
    850                 855                 860                 


Val Glu Asn Gln Lys Met Glu Glu Phe Arg Lys Glu Ile Glu Thr Leu 
865                 870                 875                 880 


Lys Gln Ala Ala Ala Gln Lys Ser Gln Gln Leu Ser Ala Leu Gln Glu 
                885                 890                 895     


Glu Asn Val Lys Leu Ala Glu Glu Leu Gly Arg Ser Arg Asp Glu Val 
            900                 905                 910         


Thr Ser His Gln Lys Leu Glu Glu Glu Arg Ser Val Leu Asn Asn Gln 
        915                 920                 925             


Leu Leu Glu Met Lys Lys Arg Glu Ser Lys Phe Ile Lys Asp Ala Asp 
    930                 935                 940                 


Glu Glu Lys Ala Ser Leu Gln Lys Ser Ile Ser Ile Thr Ser Ala Leu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Glu Leu Glu Lys Leu Arg Asn Glu Val Thr 
                965                 970                 975     


Val Leu Arg Gly Glu Asn Ala Ser Ala Lys Ser Leu His Ser Val Val 
            980                 985                 990         


Gln Thr Leu Glu Ser Asp Lys Val  Lys Leu Glu Leu Lys  Val Lys Asn 
        995                 1000                 1005             


Leu Glu  Leu Gln Leu Lys Glu  Asn Lys Arg Gln Leu  Ser Ser Ser 
    1010                 1015                 1020             


Ser Gly  Asn Thr Asp Thr Gln  Ala Asp Glu Asp Glu  Arg Ala Gln 
    1025                 1030                 1035             


Glu Ser  Gln Asn Gln Ile Asp  Phe Leu Asn Ser Val  Ile Val Asp 
    1040                 1045                 1050             


Leu Gln  Arg Lys Asn Gln Asp  Leu Lys Met Lys Val  Glu Met Met 
    1055                 1060                 1065             


Ser Glu  Ala Ala Leu Asn Gly  Asn Gly Asp Asp Leu  Asn Asn Tyr 
    1070                 1075                 1080             


Asp Ser  Asp Asp Gln Glu Lys  Gln Ser Lys Lys Lys  Pro Arg Leu 
    1085                 1090                 1095             


Phe Cys  Asp Ile Cys Asp Cys  Phe Asp Leu His Asp  Thr Glu Asp 
    1100                 1105                 1110             


Cys Pro  Thr Gln Ala Gln Met  Ser Glu Asp Pro Pro  His Ser Thr 
    1115                 1120                 1125             


His His  Gly Ser Arg Gly Glu  Glu Arg Pro Tyr Cys  Glu Ile Cys 
    1130                 1135                 1140             


Glu Met  Phe Gly His Trp Ala  Thr Asn Cys Asn Asp  Asp Glu Thr 
    1145                 1150                 1155             


Phe 
    


<210> 8901
<211> 251
<212> PRT
<213> Homo sapiens

<400> 8901
Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Ile Lys Lys Lys Lys Lys Lys Lys 
                245                 250     


<210> 8902
<211> 1062
<212> PRT
<213> Homo sapiens

<400> 8902
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg 
            100                 105                 110         


Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys 
        115                 120                 125             


Thr Glu Ala Gln Ala Phe Thr Glu Thr Lys Gly Asn Val Ile Cys Leu 
    130                 135                 140                 


Gly Lys Glu Val Phe Lys Gly Lys Lys Pro Asp Lys Asp Asn Arg Cys 
145                 150                 155                 160 


Arg Tyr Ile Leu Lys Thr Lys Phe Arg Glu Met Trp Lys Ser Trp Pro 
                165                 170                 175     


Gly Asp Ser Lys Glu Val Gln Val Met Ala Glu Arg Tyr Lys Met Leu 
            180                 185                 190         


Ile Pro Phe Ser Asn Pro Arg Val Leu Pro Gly Pro Phe Ser Tyr Thr 
        195                 200                 205             


Val Val Leu Tyr Gly Pro Ala Gly Leu Gly Lys Thr Thr Leu Ala Gln 
    210                 215                 220                 


Lys Leu Met Leu Asp Trp Ala Glu Asp Asn Leu Ile His Lys Phe Lys 
225                 230                 235                 240 


Tyr Ala Phe Tyr Leu Ser Cys Arg Glu Leu Ser Arg Leu Gly Pro Cys 
                245                 250                 255     


Ser Phe Ala Glu Leu Val Phe Arg Asp Trp Pro Glu Leu Gln Asp Asp 
            260                 265                 270         


Ile Pro His Ile Leu Ala Gln Ala Arg Lys Ile Leu Phe Val Ile Asp 
        275                 280                 285             


Gly Phe Asp Glu Leu Gly Ala Ala Pro Gly Ala Leu Ile Glu Asp Ile 
    290                 295                 300                 


Cys Gly Asp Trp Glu Lys Lys Lys Pro Val Pro Val Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Leu Asn Arg Val Met Leu Pro Lys Ala Ala Leu Leu Val Thr Thr 
                325                 330                 335     


Arg Pro Arg Ala Leu Arg Asp Leu Arg Ile Leu Ala Glu Glu Pro Ile 
            340                 345                 350         


Tyr Ile Arg Val Glu Gly Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe 
        355                 360                 365             


Leu Arg His Phe Gly Asp Glu Asp Gln Ala Met Arg Ala Phe Glu Leu 
    370                 375                 380                 


Met Arg Ser Asn Ala Ala Leu Phe Gln Leu Gly Ser Ala Pro Ala Val 
385                 390                 395                 400 


Cys Trp Ile Val Cys Thr Thr Leu Lys Leu Gln Met Glu Lys Gly Glu 
                405                 410                 415     


Asp Pro Val Pro Thr Cys Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe 
            420                 425                 430         


Leu Cys Ser Arg Phe Pro Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg 
        435                 440                 445             


Thr Leu Ser Leu Leu Ala Ala Gln Gly Leu Trp Ala Gln Thr Ser Val 
    450                 455                 460                 


Leu His Arg Glu Asp Leu Glu Arg Leu Gly Val Gln Glu Ser Asp Leu 
465                 470                 475                 480 


Arg Leu Phe Leu Asp Gly Asp Ile Leu Arg Gln Asp Arg Val Ser Lys 
                485                 490                 495     


Gly Cys Tyr Ser Phe Ile His Leu Ser Phe Gln Gln Phe Leu Thr Ala 
            500                 505                 510         


Leu Phe Tyr Thr Leu Glu Lys Glu Glu Glu Glu Asp Arg Asp Gly His 
        515                 520                 525             


Thr Trp Asp Ile Gly Asp Val Gln Lys Leu Leu Ser Gly Val Glu Arg 
    530                 535                 540                 


Leu Arg Asn Pro Asp Leu Ile Gln Ala Gly Tyr Tyr Ser Phe Gly Leu 
545                 550                 555                 560 


Ala Asn Glu Lys Arg Ala Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg 
                565                 570                 575     


Met Ser Pro Asp Ile Lys Gln Glu Leu Leu Arg Cys Asp Ile Ser Cys 
            580                 585                 590         


Lys Gly Gly His Ser Thr Val Thr Asp Leu Gln Glu Leu Leu Gly Cys 
        595                 600                 605             


Leu Tyr Glu Ser Gln Glu Glu Glu Leu Val Lys Glu Val Met Ala Gln 
    610                 615                 620                 


Phe Lys Glu Ile Ser Leu His Leu Asn Ala Val Asp Val Val Pro Ser 
625                 630                 635                 640 


Ser Phe Cys Val Lys His Cys Arg Asn Leu Gln Lys Met Ser Leu Gln 
                645                 650                 655     


Val Ile Lys Glu Asn Leu Pro Glu Asn Val Thr Ala Ser Glu Ser Asp 
            660                 665                 670         


Ala Glu Val Glu Arg Ser Gln Asp Asp Gln His Met Leu Pro Phe Trp 
        675                 680                 685             


Thr Asp Leu Cys Ser Ile Phe Gly Ser Asn Lys Asp Leu Met Gly Leu 
    690                 695                 700                 


Ala Ile Asn Asp Ser Phe Leu Ser Ala Ser Leu Val Arg Ile Leu Cys 
705                 710                 715                 720 


Glu Gln Ile Ala Ser Asp Thr Cys His Leu Gln Arg Val Val Phe Lys 
                725                 730                 735     


Asn Ile Ser Pro Ala Asp Ala His Arg Asn Leu Cys Leu Ala Leu Arg 
            740                 745                 750         


Gly His Lys Thr Val Thr Tyr Leu Thr Leu Gln Gly Asn Asp Gln Asp 
        755                 760                 765             


Asp Met Phe Pro Ala Leu Cys Glu Val Leu Arg His Pro Glu Cys Asn 
    770                 775                 780                 


Leu Arg Tyr Leu Gly Leu Val Ser Cys Ser Ala Thr Thr Gln Gln Trp 
785                 790                 795                 800 


Ala Asp Leu Ser Leu Ala Leu Glu Val Asn Gln Ser Leu Thr Cys Val 
                805                 810                 815     


Asn Leu Ser Asp Asn Glu Leu Leu Asp Glu Gly Ala Lys Leu Leu Tyr 
            820                 825                 830         


Thr Thr Leu Arg His Pro Lys Cys Phe Leu Gln Arg Leu Ser Leu Glu 
        835                 840                 845             


Asn Cys His Leu Thr Glu Ala Asn Cys Lys Asp Leu Ala Ala Val Leu 
    850                 855                 860                 


Val Val Ser Arg Glu Leu Thr His Leu Cys Leu Ala Lys Asn Pro Ile 
865                 870                 875                 880 


Gly Asn Thr Gly Val Lys Phe Leu Cys Glu Gly Leu Arg Tyr Pro Glu 
                885                 890                 895     


Cys Lys Leu Gln Thr Leu Val Leu Trp Asn Cys Asp Ile Thr Ser Asp 
            900                 905                 910         


Gly Cys Cys Asp Leu Thr Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu 
        915                 920                 925             


Cys Leu Asp Leu Gly Leu Asn His Ile Gly Val Lys Gly Met Lys Phe 
    930                 935                 940                 


Leu Cys Glu Ala Leu Arg Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp 
945                 950                 955                 960 


Leu Trp Gly Cys Ser Ile Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser 
                965                 970                 975     


Ala Leu Ser Cys Asn Gln Ser Leu Val Thr Leu Asp Leu Gly Gln Asn 
            980                 985                 990         


Pro Leu Gly Ser Ser Gly Val Lys  Met Leu Phe Glu Thr  Leu Thr Cys 
        995                 1000                 1005             


Ser Ser  Gly Thr Leu Arg Thr  Leu Arg Leu Lys Ile  Asp Asp Phe 
    1010                 1015                 1020             


Asn Asp  Glu Leu Asn Lys Leu  Leu Glu Glu Ile Glu  Glu Lys Asn 
    1025                 1030                 1035             


Pro Gln  Leu Ile Ile Asp Thr  Glu Lys His His Pro  Trp Ala Glu 
    1040                 1045                 1050             


Arg Pro  Ser Ser His Asp Phe  Met Ile 
    1055                 1060         


<210> 8903
<211> 120
<212> PRT
<213> Homo sapiens

<400> 8903
Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly Gly Leu Leu 
1               5                   10                  15      


Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys Cys Ser Tyr 
            20                  25                  30          


Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp Pro Val Ala 
        35                  40                  45              


Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu His Arg Thr 
    50                  55                  60                  


Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly Asp Leu Glu 
65                  70                  75                  80  


Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn Gly Lys Val 
                85                  90                  95      


Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala Gln Leu Asn 
            100                 105                 110         


Ile Glu Leu Glu Ala Ala His His 
        115                 120 


<210> 8904
<211> 311
<212> PRT
<213> Homo sapiens

<400> 8904
Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser Thr Asp Val 
1               5                   10                  15      


Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr Val Lys Val 
            20                  25                  30          


Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala Glu Gly Glu 
        35                  40                  45              


Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln Thr Asp Val 
    50                  55                  60                  


Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp Leu Asp Lys 
65                  70                  75                  80  


Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro Asn Asn Gly 
                85                  90                  95      


Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys Val Arg Gln 
            100                 105                 110         


Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys Glu Met Ile 
        115                 120                 125             


Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys Ala Leu Glu 
    130                 135                 140                 


Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala Glu Phe Leu 
145                 150                 155                 160 


Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val Pro Asp Ala 
                165                 170                 175     


Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln Lys Tyr Asn 
            180                 185                 190         


Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu Gly Leu Ser 
        195                 200                 205             


Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp Gln Pro Gln 
    210                 215                 220                 


Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn Tyr Trp Tyr 
225                 230                 235                 240 


Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu Gln Ala Ala 
                245                 250                 255     


Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp Ala Pro Ser 
            260                 265                 270         


Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu Asp Gly Ser 
        275                 280                 285             


Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg Glu Leu Leu 
    290                 295                 300                 


Ser Asn Ser Glu Gln Leu Asn 
305                 310     


<210> 8905
<211> 1088
<212> PRT
<213> Homo sapiens

<400> 8905
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Ile Gly Gln Val Lys Gln Glu Leu Ser 
        435                 440                 445             


Arg Lys Asp Thr Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu 
    450                 455                 460                 


Thr Asn Gln Phe Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Thr Ala Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val 
                485                 490                 495     


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
            500                 505                 510         


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
        515                 520                 525             


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
    530                 535                 540                 


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
545                 550                 555                 560 


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
                565                 570                 575     


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
            580                 585                 590         


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
        595                 600                 605             


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
    610                 615                 620                 


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
625                 630                 635                 640 


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
                645                 650                 655     


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
            660                 665                 670         


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
        675                 680                 685             


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
    690                 695                 700                 


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
705                 710                 715                 720 


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
                725                 730                 735     


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
            740                 745                 750         


Glu Leu Glu Arg Gln Val Lys Asp Gln Asn Lys Lys Val Ala Asn Leu 
        755                 760                 765             


Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala Gln Met Leu Glu 
    770                 775                 780                 


Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser Ser Gln Gln Leu 
785                 790                 795                 800 


Gln Asp Ser Leu Arg Lys Lys Asp Asp Arg Ile Glu Glu Leu Glu Glu 
                805                 810                 815     


Ala Leu Arg Glu Ser Val Gln Ile Thr Ala Glu Arg Glu Met Val Leu 
            820                 825                 830         


Ala Gln Glu Glu Ser Ala Arg Thr Asn Ala Glu Lys Gln Val Glu Glu 
        835                 840                 845             


Leu Leu Met Ala Met Glu Lys Val Lys Gln Glu Leu Glu Ser Met Lys 
    850                 855                 860                 


Ala Lys Leu Ser Ser Thr Gln Gln Ser Leu Ala Glu Lys Glu Thr His 
865                 870                 875                 880 


Leu Thr Asn Leu Arg Ala Glu Arg Arg Lys His Leu Glu Glu Val Leu 
                885                 890                 895     


Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser Glu Lys Asp Ala 
            900                 905                 910         


Asn Ile Ala Leu Leu Glu Leu Ser Ser Ser Lys Lys Lys Thr Gln Glu 
        915                 920                 925             


Glu Val Ala Ala Leu Lys Arg Glu Lys Asp Arg Leu Val Gln Gln Leu 
    930                 935                 940                 


Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala Asp Asn Tyr Glu 
945                 950                 955                 960 


Asp Asp His Phe Lys Ser Ser His Ser Asn Gln Thr Asn His Lys Pro 
                965                 970                 975     


Ser Pro Asp Gln Ile Ile Gln Pro Leu Leu Glu Leu Asp Gln Asn Arg 
            980                 985                 990         


Ser Lys Leu Lys Leu Tyr Ile Gly  His Leu Thr Thr Leu  Cys His Asp 
        995                 1000                 1005             


Arg Asp  Pro Leu Ile Leu Arg  Gly Leu Thr Pro Pro  Ala Ser Tyr 
    1010                 1015                 1020             


Asn Leu  Asp Asp Asp Gln Ala  Ala Trp Glu Asn Glu  Leu Gln Lys 
    1025                 1030                 1035             


Met Thr  Arg Gly Gln Leu Gln  Asp Glu Leu Glu Lys  Gly Glu Arg 
    1040                 1045                 1050             


Asp Asn  Ala Glu Leu Gln Glu  Phe Ala Asn Ala Ile  Leu Gln Gln 
    1055                 1060                 1065             


Ile Ala  Asp His Cys Pro Asp  Ile Leu Glu Gln Val  Val Asn Ala 
    1070                 1075                 1080             


Leu Glu  Glu Ser Ser 
    1085             


<210> 8906
<211> 494
<212> PRT
<213> Homo sapiens

<400> 8906
Met Lys Leu Val Asn Leu Tyr Lys Gly Ala Val Leu Tyr Leu Leu Arg 
1               5                   10                  15      


Gly Arg Lys Thr Phe Leu Ile Pro Val Leu Phe Asn Asn Tyr Ile Thr 
            20                  25                  30          


Ala Ala Leu Lys Leu Leu Glu Lys Leu Tyr Lys Val Asn Leu Lys Val 
        35                  40                  45              


Lys His Val Glu Tyr Asp Thr Phe Tyr Ile Pro Glu Ile Ser Asn Leu 
    50                  55                  60                  


Val Asp Ile Gln Glu Asp Tyr Leu Met Trp Phe Leu His Gln Ala Gly 
65                  70                  75                  80  


Met Lys Ala Arg Pro Ser Ile Ile Gln Asp Thr Val Thr Leu Cys Ser 
                85                  90                  95      


Tyr Pro Phe Ile Phe Asp Ala Gln Ala Lys Thr Lys Met Leu Gln Thr 
            100                 105                 110         


Asp Ala Glu Leu Gln Met Gln Val Ala Val Asn Gly Ala Asn Leu Gln 
        115                 120                 125             


Asn Val Phe Met Leu Leu Thr Leu Glu Pro Leu Leu Ala Arg Ser Pro 
    130                 135                 140                 


Phe Leu Val Leu His Val Arg Arg Asn Asn Leu Val Gly Asp Ala Leu 
145                 150                 155                 160 


Arg Glu Leu Ser Ile His Ser Asp Ile Asp Leu Lys Lys Pro Leu Lys 
                165                 170                 175     


Val Ile Phe Asp Gly Glu Glu Ala Val Asp Ala Gly Gly Val Thr Lys 
            180                 185                 190         


Glu Phe Phe Leu Leu Leu Leu Lys Glu Leu Leu Asn Pro Ile Tyr Gly 
        195                 200                 205             


Met Phe Thr Tyr Tyr Gln Asp Ser Asn Leu Leu Trp Phe Ser Asp Thr 
    210                 215                 220                 


Cys Phe Val Glu His Asn Trp Phe His Leu Ile Gly Ile Thr Cys Gly 
225                 230                 235                 240 


Leu Ala Ile Tyr Asn Ser Thr Val Val Asp Leu His Phe Pro Leu Ala 
                245                 250                 255     


Leu Tyr Lys Lys Leu Leu Asn Val Lys Pro Gly Leu Glu Asp Leu Lys 
            260                 265                 270         


Glu Leu Ser Pro Thr Glu Gly Arg Ser Leu Gln Glu Leu Leu Asp Tyr 
        275                 280                 285             


Pro Gly Glu Asp Val Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Cys 
    290                 295                 300                 


Arg Glu Ser Tyr Gly Val Ile Glu Gln Lys Lys Leu Ile Pro Gly Gly 
305                 310                 315                 320 


Asp Asn Val Thr Val Cys Lys Asp Asn Arg Gln Glu Phe Val Asp Ala 
                325                 330                 335     


Tyr Val Asn Tyr Val Phe Gln Ile Ser Val His Glu Trp Tyr Thr Ala 
            340                 345                 350         


Phe Ser Ser Gly Phe Leu Lys Val Cys Gly Gly Lys Val Leu Glu Leu 
        355                 360                 365             


Phe Gln Pro Ser Glu Leu Arg Ala Met Met Val Gly Asn Ser Asn Tyr 
    370                 375                 380                 


Asn Trp Glu Glu Leu Glu Glu Thr Ala Ile Tyr Lys Gly Asp Tyr Ser 
385                 390                 395                 400 


Ala Thr His Pro Thr Val Lys Leu Phe Trp Glu Thr Phe His Glu Phe 
                405                 410                 415     


Pro Leu Glu Lys Lys Lys Lys Phe Leu Leu Phe Leu Thr Gly Ser Asp 
            420                 425                 430         


Arg Ile Pro Ile Tyr Gly Met Ala Ser Leu Gln Ile Val Ile Gln Ser 
        435                 440                 445             


Thr Ala Ser Gly Glu Glu Tyr Leu Pro Val Ala His Thr Cys Tyr Asn 
    450                 455                 460                 


Leu Leu Asp Leu Pro Lys Tyr Ser Ser Lys Glu Ile Leu Ser Ala Arg 
465                 470                 475                 480 


Leu Thr Gln Ala Leu Asp Asn Tyr Glu Gly Phe Ser Leu Ala 
                485                 490                 


<210> 8907
<211> 789
<212> PRT
<213> Homo sapiens

<400> 8907
Met Cys Pro Ser Ser Gln Ser Pro Arg Pro Pro Leu Leu Arg Pro Pro 
1               5                   10                  15      


Cys Ser Tyr Arg Glu Val Pro Ser Ser Val Gln Ser Pro Ala Gln Gln 
            20                  25                  30          


Gln Val Pro Ala Arg Pro Gly Ala Pro Ser Val Gln Val Pro Ser Pro 
        35                  40                  45              


Phe Leu Leu Gln Asn Gln Tyr Glu Pro Val Gln Pro His Trp Phe Tyr 
    50                  55                  60                  


Cys Lys Glu Val Glu Tyr Lys Gln Leu Trp Met Pro Phe Ser Val Phe 
65                  70                  75                  80  


Asp Ser Leu Asn Leu Glu Glu Ile Tyr Asn Ser Val Gln Pro Asp Pro 
                85                  90                  95      


Glu Ser Val Val Leu Gly Thr Asp Gly Gly Arg Tyr Asp Val Tyr Leu 
            100                 105                 110         


Tyr Asp Arg Ile Arg Lys Ala Ala Tyr Trp Glu Glu Glu Pro Ala Glu 
        115                 120                 125             


Val Arg Arg Cys Thr Trp Phe Tyr Lys Gly Asp Thr Asp Ser Arg Phe 
    130                 135                 140                 


Ile Pro Tyr Thr Glu Glu Phe Ser Glu Lys Leu Glu Ala Glu Tyr Lys 
145                 150                 155                 160 


Lys Ala Val Thr Thr Asn Gln Trp His Arg Arg Leu Glu Phe Pro Ser 
                165                 170                 175     


Gly Glu Thr Ile Val Met His Asn Pro Lys Val Ile Val Gln Phe Gln 
            180                 185                 190         


Pro Ser Ser Val Pro Asp Glu Trp Gly Thr Thr Gln Asp Gly Gln Thr 
        195                 200                 205             


Arg Pro Arg Val Val Lys Arg Gly Ile Asp Asp Asn Leu Asp Glu Ile 
    210                 215                 220                 


Pro Asp Gly Glu Met Pro Gln Val Asp His Leu Val Phe Val Val His 
225                 230                 235                 240 


Gly Ile Gly Pro Val Cys Asp Leu Arg Phe Arg Ser Ile Ile Glu Cys 
                245                 250                 255     


Val Asp Asp Phe Arg Val Val Ser Leu Lys Leu Leu Arg Thr His Phe 
            260                 265                 270         


Lys Lys Ser Leu Asp Asp Gly Lys Val Ser Arg Val Glu Phe Leu Pro 
        275                 280                 285             


Val His Trp His Ser Ser Leu Gly Gly Asp Ala Thr Gly Val Asp Arg 
    290                 295                 300                 


Asn Ile Lys Lys Ile Thr Leu Pro Ser Ile Gly Arg Phe Arg His Phe 
305                 310                 315                 320 


Thr Asn Glu Thr Leu Leu Asp Ile Leu Phe Tyr Asn Ser Pro Thr Tyr 
                325                 330                 335     


Cys Gln Thr Ile Val Glu Lys Val Gly Met Glu Ile Asn His Leu His 
            340                 345                 350         


Ala Leu Phe Met Ser Arg Asn Pro Asp Phe Lys Gly Gly Val Ser Val 
        355                 360                 365             


Ala Gly His Ser Leu Gly Ser Leu Ile Leu Phe Asp Ile Leu Ser Asn 
    370                 375                 380                 


Gln Lys Asp Leu Asn Leu Ser Lys Cys Pro Gly Pro Leu Ala Val Ala 
385                 390                 395                 400 


Asn Gly Val Val Lys Gln Leu His Phe Gln Glu Lys Gln Met Pro Glu 
                405                 410                 415     


Glu Pro Lys Leu Thr Leu Asp Glu Ser Tyr Asp Leu Val Val Glu Asn 
            420                 425                 430         


Lys Glu Val Leu Thr Leu Gln Glu Thr Leu Glu Ala Leu Ser Leu Ser 
        435                 440                 445             


Glu Tyr Phe Ser Thr Phe Glu Lys Glu Lys Ile Asp Met Glu Ser Leu 
    450                 455                 460                 


Leu Met Cys Thr Val Asp Asp Leu Lys Glu Met Gly Ile Pro Leu Gly 
465                 470                 475                 480 


Pro Arg Lys Lys Ile Ala Asn Phe Val Glu His Lys Ala Ala Lys Leu 
                485                 490                 495     


Lys Lys Ala Ala Ser Glu Lys Lys Ala Val Ala Ala Thr Ser Thr Lys 
            500                 505                 510         


Gly Gln Glu Gln Ser Ala Gln Lys Thr Lys Asp Met Ala Ser Leu Pro 
        515                 520                 525             


Ser Glu Ser Asn Glu Pro Lys Arg Lys Leu Pro Val Gly Ala Cys Val 
    530                 535                 540                 


Ser Ser Val Cys Val Asn Tyr Glu Ser Phe Glu Val Gly Ala Gly Gln 
545                 550                 555                 560 


Val Ser Val Ala Tyr Asn Ser Leu Asp Phe Glu Pro Glu Ile Phe Phe 
                565                 570                 575     


Ala Leu Gly Ser Pro Ile Ala Met Phe Leu Thr Ile Arg Gly Val Asp 
            580                 585                 590         


Arg Ile Asp Glu Asn Tyr Ser Leu Pro Thr Cys Lys Gly Phe Phe Asn 
        595                 600                 605             


Ile Tyr His Pro Leu Asp Pro Val Ala Tyr Arg Leu Glu Pro Met Ile 
    610                 615                 620                 


Val Pro Asp Leu Asp Leu Lys Ala Val Leu Ile Pro His His Lys Gly 
625                 630                 635                 640 


Arg Lys Arg Leu His Leu Glu Leu Lys Glu Ser Leu Ser Arg Met Gly 
                645                 650                 655     


Ser Asp Leu Lys Gln Gly Phe Ile Ser Ser Leu Lys Ser Ala Trp Gln 
            660                 665                 670         


Thr Leu Asn Glu Phe Ala Arg Ala His Thr Ser Ser Thr Gln Leu Gln 
        675                 680                 685             


Glu Glu Leu Glu Lys Val Ala Asn Gln Ile Lys Glu Glu Glu Glu Lys 
    690                 695                 700                 


Gln Val Val Glu Ala Glu Lys Val Val Glu Ser Pro Asp Phe Ser Lys 
705                 710                 715                 720 


Asp Glu Asp Tyr Leu Gly Lys Val Gly Met Leu Asn Gly Gly Arg Arg 
                725                 730                 735     


Ile Asp Tyr Val Leu Gln Glu Lys Pro Ile Glu Ser Phe Asn Glu Tyr 
            740                 745                 750         


Leu Phe Ala Leu Gln Ser His Leu Cys Tyr Trp Glu Ser Glu Asp Thr 
        755                 760                 765             


Ala Leu Leu Leu Leu Lys Glu Ile Tyr Arg Thr Met Asn Ile Ser Pro 
    770                 775                 780                 


Glu Gln Pro Gln His 
785                 


<210> 8908
<211> 275
<212> PRT
<213> Homo sapiens

<400> 8908
Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210> 8909
<211> 79
<212> PRT
<213> Homo sapiens

<400> 8909
Met Asn Gly Thr Leu Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu 
            20                  25                  30          


Arg Glu Leu Phe Glu Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu 
65                  70                  75                  


<210> 8910
<211> 245
<212> PRT
<213> Homo sapiens

<400> 8910
Met Val Leu Leu His Val Lys Arg Gly Asp Glu Ser Gln Phe Leu Leu 
1               5                   10                  15      


Gln Ala Pro Gly Ser Thr Glu Leu Glu Glu Leu Thr Val Gln Val Ala 
            20                  25                  30          


Arg Val Tyr Asn Gly Arg Leu Lys Val Gln Arg Leu Cys Ser Glu Met 
        35                  40                  45              


Glu Glu Leu Ala Glu His Gly Ile Phe Leu Pro Pro Asn Met Gln Gly 
    50                  55                  60                  


Leu Thr Asp Asp Gln Ile Glu Glu Leu Lys Leu Lys Asp Glu Trp Gly 
65                  70                  75                  80  


Glu Lys Cys Val Pro Ser Gly Gly Ala Val Phe Lys Lys Asp Asp Ile 
                85                  90                  95      


Gly Arg Arg Asn Gly Gln Ala Pro Asn Glu Lys Met Lys Gln Val Leu 
            100                 105                 110         


Lys Lys Thr Ile Glu Glu Ala Lys Ala Ile Ile Ser Lys Lys Gln Val 
        115                 120                 125             


Glu Ala Gly Val Cys Val Thr Met Glu Met Val Lys Asp Ala Leu Asp 
    130                 135                 140                 


Gln Leu Arg Gly Ala Val Met Ile Val Tyr Pro Met Gly Leu Pro Pro 
145                 150                 155                 160 


Tyr Asp Pro Ile Arg Met Glu Phe Glu Asn Lys Glu Asp Leu Ser Gly 
                165                 170                 175     


Thr Gln Ala Gly Leu Asn Val Ile Lys Glu Ala Glu Ala Gln Leu Trp 
            180                 185                 190         


Trp Ala Ala Lys Glu Leu Arg Arg Thr Lys Lys Leu Ser Asp Tyr Val 
        195                 200                 205             


Gly Lys Asn Glu Lys Thr Lys Ile Ile Ala Lys Ile Gln Gln Val Ser 
    210                 215                 220                 


Thr Phe Cys Phe Asn Val Ser Val Val Phe Val Ile Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Lys Asn Val Gln 
                245 


<210> 8911
<211> 131
<212> PRT
<213> Homo sapiens

<400> 8911
Met Ala Met Thr Ala Gly Thr Thr Thr Thr Phe Pro Met Ser Asn His 
1               5                   10                  15      


Thr Arg Glu Arg Val Thr Val Ala Lys Leu Thr Leu Glu Asn Phe Tyr 
            20                  25                  30          


Ser Asn Leu Ile Leu Gln His Glu Glu Arg Glu Thr Arg Gln Lys Lys 
        35                  40                  45              


Leu Glu Val Ala Met Glu Glu Glu Gly Leu Ala Asp Glu Glu Lys Lys 
    50                  55                  60                  


Leu Arg Arg Ser Gln His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Arg Leu Gly Leu Asp Asp Phe Glu Ser Leu Lys Val Ile 
                85                  90                  95      


Gly Arg Gly Ala Phe Gly Glu Val Arg Leu Val Gln Lys Lys Asp Thr 
            100                 105                 110         


Gly His Ile Tyr Ala Met Lys Ile Leu Arg Lys Ser Asp Met Leu Glu 
        115                 120                 125             


Lys Glu Gln 
    130     


<210> 8912
<211> 838
<212> PRT
<213> Homo sapiens

<400> 8912
Met Thr Gly Ala Glu Ile Glu Pro Ser Ala Gln Ala Lys Pro Glu Lys 
1               5                   10                  15      


Lys Ala Gly Glu Glu Val Ile Ala Gly Pro Glu Arg Glu Asn Asp Val 
            20                  25                  30          


Pro Leu Val Val Arg Pro Lys Val Arg Thr Gln Ala Thr Thr Gly Ala 
        35                  40                  45              


Arg Pro Lys Thr Glu Thr Lys Ser Val Pro Ala Ala Arg Pro Lys Thr 
    50                  55                  60                  


Glu Ala Gln Ala Met Ser Gly Ala Arg Pro Lys Thr Glu Val Gln Val 
65                  70                  75                  80  


Met Gly Gly Ala Arg Pro Lys Thr Glu Ala Gln Gly Ile Thr Gly Ala 
                85                  90                  95      


Arg Pro Lys Thr Asp Ala Arg Ala Val Gly Gly Ala Arg Ser Lys Thr 
            100                 105                 110         


Asp Ala Lys Ala Ile Pro Gly Ala Arg Pro Lys Asp Glu Ala Gln Ala 
        115                 120                 125             


Trp Ala Gln Ser Glu Phe Gly Thr Glu Ala Val Ser Gln Ala Glu Gly 
    130                 135                 140                 


Val Ser Gln Thr Asn Ala Val Ala Trp Pro Leu Ala Thr Ala Glu Ser 
145                 150                 155                 160 


Gly Ser Val Thr Lys Ser Lys Gly Leu Ser Met Asp Arg Glu Leu Val 
                165                 170                 175     


Asn Val Asp Ala Glu Thr Phe Pro Gly Thr Gln Gly Gln Lys Gly Ile 
            180                 185                 190         


Gln Pro Trp Phe Gly Pro Gly Glu Glu Thr Asn Met Gly Ser Trp Cys 
        195                 200                 205             


Tyr Ser Arg Pro Arg Ala Arg Glu Glu Ala Ser Asn Glu Ser Gly Phe 
    210                 215                 220                 


Trp Ser Ala Asp Glu Thr Ser Thr Ala Ser Ser Phe Trp Thr Gly Glu 
225                 230                 235                 240 


Glu Thr Ser Val Arg Ser Trp Pro Arg Glu Glu Ser Asn Thr Arg Ser 
                245                 250                 255     


Arg His Arg Ala Lys His Gln Thr Asn Pro Arg Ser Arg Pro Arg Ser 
            260                 265                 270         


Lys Gln Glu Ala Tyr Val Asp Ser Trp Ser Gly Ser Glu Asp Glu Ala 
        275                 280                 285             


Ser Asn Pro Phe Ser Phe Trp Val Gly Glu Asn Thr Asn Asn Leu Phe 
    290                 295                 300                 


Arg Pro Arg Val Arg Glu Glu Ala Asn Ile Arg Ser Lys Leu Arg Thr 
305                 310                 315                 320 


Asn Arg Glu Asp Cys Phe Glu Ser Glu Ser Glu Asp Glu Phe Tyr Lys 
                325                 330                 335     


Gln Ser Trp Val Leu Pro Gly Glu Glu Ala Asn Ser Arg Phe Arg His 
            340                 345                 350         


Arg Asp Lys Glu Asp Pro Asn Thr Ala Leu Lys Leu Arg Ala Gln Lys 
        355                 360                 365             


Asp Val Asp Ser Asp Arg Val Lys Gln Glu Pro Arg Phe Glu Glu Glu 
    370                 375                 380                 


Val Ile Ile Gly Ser Trp Phe Trp Ala Glu Lys Glu Ala Ser Leu Glu 
385                 390                 395                 400 


Gly Gly Ala Ser Ala Ile Cys Glu Ser Glu Pro Gly Thr Glu Glu Gly 
                405                 410                 415     


Ala Ile Gly Gly Ser Ala Tyr Trp Ala Glu Glu Lys Ser Ser Leu Gly 
            420                 425                 430         


Ala Val Ala Arg Glu Glu Ala Lys Pro Glu Ser Glu Glu Glu Ala Ile 
        435                 440                 445             


Phe Gly Ser Trp Phe Trp Asp Arg Asp Glu Ala Cys Phe Asp Leu Asn 
    450                 455                 460                 


Pro Cys Pro Val Tyr Lys Val Ser Asp Arg Phe Arg Asp Ala Ala Glu 
465                 470                 475                 480 


Glu Leu Asn Ala Ser Ser Arg Pro Gln Thr Trp Asp Glu Val Thr Val 
                485                 490                 495     


Glu Phe Lys Pro Gly Leu Phe His Gly Val Gly Phe Arg Ser Thr Ser 
            500                 505                 510         


Pro Phe Gly Ile Pro Glu Glu Ala Ser Glu Met Leu Glu Ala Lys Pro 
        515                 520                 525             


Lys Asn Leu Glu Leu Ser Pro Glu Gly Glu Glu Gln Glu Ser Leu Leu 
    530                 535                 540                 


Gln Pro Asp Gln Pro Ser Pro Glu Phe Thr Phe Gln Tyr Asp Pro Ser 
545                 550                 555                 560 


Tyr Arg Ser Val Arg Glu Ile Arg Glu His Leu Arg Ala Arg Glu Ser 
                565                 570                 575     


Ala Glu Ser Glu Ser Trp Ser Cys Ser Cys Ile Gln Cys Glu Leu Lys 
            580                 585                 590         


Ile Gly Ser Glu Glu Phe Glu Glu Phe Leu Leu Leu Met Asp Lys Ile 
        595                 600                 605             


Arg Asp Pro Phe Ile His Glu Ile Ser Lys Ile Ala Met Gly Met Arg 
    610                 615                 620                 


Ser Ala Ser Gln Phe Thr Arg Asp Phe Ile Arg Asp Ser Gly Val Val 
625                 630                 635                 640 


Ser Leu Ile Glu Thr Leu Leu Asn Tyr Pro Ser Ser Arg Val Arg Thr 
                645                 650                 655     


Ser Phe Leu Glu Asn Met Ile His Met Ala Pro Pro Tyr Pro Asn Leu 
            660                 665                 670         


Asn Met Ile Glu Thr Phe Ile Cys Gln Val Cys Glu Glu Thr Leu Ala 
        675                 680                 685             


His Ser Val Asp Ser Leu Glu Gln Leu Thr Gly Ile Arg Met Leu Arg 
    690                 695                 700                 


His Leu Thr Met Thr Ile Asp Tyr His Thr Leu Ile Ala Asn Tyr Met 
705                 710                 715                 720 


Ser Gly Phe Leu Ser Leu Leu Thr Thr Ala Asn Ala Arg Thr Lys Phe 
                725                 730                 735     


His Val Leu Lys Met Leu Leu Asn Leu Ser Glu Asn Pro Ala Val Ala 
            740                 745                 750         


Lys Lys Leu Phe Ser Ala Lys Ala Leu Ser Ile Phe Val Gly Leu Phe 
        755                 760                 765             


Asn Ile Glu Glu Thr Asn Asp Asn Ile Gln Ile Val Ile Lys Met Phe 
    770                 775                 780                 


Gln Asn Ile Ser Asn Ile Ile Lys Ser Gly Lys Met Ser Leu Ile Asp 
785                 790                 795                 800 


Asp Asp Phe Ser Leu Glu Pro Leu Ile Ser Ala Phe Arg Glu Phe Glu 
                805                 810                 815     


Glu Leu Ala Lys Gln Leu Gln Ala Gln Ile Asp Asn Gln Asn Asp Pro 
            820                 825                 830         


Glu Val Gly Gln Gln Ser 
        835             


<210> 8913
<211> 404
<212> PRT
<213> Homo sapiens

<400> 8913
Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Ala Glu Gly Pro Thr 
            180                 185                 190         


Val Pro Asp Phe Gln Glu Thr Arg Pro Arg Asn Tyr Ile Leu Ser Ala 
        195                 200                 205             


Ser Ala Ser Ala Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gln Glu 
    210                 215                 220                 


Leu Arg Val Ala Gln Thr Glu Phe Asp Arg Gln Ala Glu Val Thr Arg 
225                 230                 235                 240 


Leu Leu Leu Glu Gly Ile Ser Ser Thr His Val Asn His Leu Arg Cys 
                245                 250                 255     


Leu His Glu Phe Val Lys Ser Gln Thr Thr Tyr Tyr Ala Gln Cys Tyr 
            260                 265                 270         


Arg His Met Leu Asp Leu Gln Lys Gln Leu Gly Ser Ser Gln Gly Ala 
        275                 280                 285             


Ile Phe Pro Gly Thr Phe Val Gly Thr Thr Glu Pro Ala Ser Pro Pro 
    290                 295                 300                 


Leu Ser Ser Thr Ser Pro Thr Thr Ala Ala Ala Thr Met Pro Val Val 
305                 310                 315                 320 


Pro Ser Val Ala Ser Leu Ala Pro Pro Gly Glu Ala Ser Leu Cys Leu 
                325                 330                 335     


Glu Glu Val Ala Pro Pro Ala Ser Gly Thr Arg Lys Ala Arg Val Leu 
            340                 345                 350         


Tyr Asp Tyr Glu Ala Ala Asp Ser Ser Glu Leu Ala Leu Leu Ala Asp 
        355                 360                 365             


Glu Leu Ile Thr Val Tyr Ser Leu Pro Gly Met Asp Pro Asp Trp Leu 
    370                 375                 380                 


Ile Gly Glu Arg Gly Asn Lys Lys Gly Lys Val Pro Val Thr Tyr Leu 
385                 390                 395                 400 


Glu Leu Leu Ser 
                


<210> 8914
<211> 164
<212> PRT
<213> Homo sapiens

<400> 8914
Met Thr Cys Cys Gln Thr Ser Phe Cys Gly Tyr Pro Ser Phe Ser Ile 
1               5                   10                  15      


Ser Gly Thr Cys Gly Ser Ser Cys Cys Gln Pro Ser Cys Cys Glu Thr 
            20                  25                  30          


Ser Cys Cys Gln Pro Arg Ser Cys Gln Thr Ser Phe Cys Gly Phe Pro 
        35                  40                  45              


Ser Phe Ser Thr Ser Gly Thr Cys Ser Ser Ser Cys Cys Gln Pro Ser 
    50                  55                  60                  


Cys Cys Glu Thr Ser Cys Cys Gln Pro Ser Cys Cys Gln Ile Ser Ser 
65                  70                  75                  80  


Cys Gly Thr Gly Cys Gly Ile Gly Gly Gly Ile Ser Tyr Gly Gln Glu 
                85                  90                  95      


Gly Ser Ser Gly Ala Val Ser Thr Arg Ile Arg Trp Cys Arg Pro Asp 
            100                 105                 110         


Ser Arg Val Glu Gly Thr Tyr Leu Pro Pro Cys Cys Val Val Ser Cys 
        115                 120                 125             


Thr Pro Pro Ser Cys Cys Gln Leu His His Ala Gln Ala Ser Cys Cys 
    130                 135                 140                 


Arg Pro Ser Tyr Cys Gly Gln Ser Cys Cys Arg Pro Val Cys Cys Cys 
145                 150                 155                 160 


Glu Pro Thr Cys 
                


<210> 8915
<211> 281
<212> PRT
<213> Homo sapiens

<400> 8915
Met Leu Thr Lys Leu Gln Ile Lys Gln Met Met Glu Ala Ala Thr Arg 
1               5                   10                  15      


Gln Ile Glu Glu Arg Lys Lys Gln Leu Ser Phe Ile Ser Pro Pro Thr 
            20                  25                  30          


Pro Gln Pro Lys Thr Pro Ser Ser Ser Gln Pro Glu Arg Leu Pro Ile 
        35                  40                  45              


Gly Asn Thr Ile Gln Pro Ser Gln Ala Ala Thr Phe Met Asn Asp Ala 
    50                  55                  60                  


Ile Glu Lys Ala Arg Lys Ala Ala Glu Leu Gln Ala Arg Ile Gln Ala 
65                  70                  75                  80  


Gln Leu Ala Leu Lys Pro Gly Leu Ile Gly Asn Ala Asn Met Val Gly 
                85                  90                  95      


Leu Ala Asn Leu His Ala Met Gly Ile Ala Pro Pro Lys Val Glu Leu 
            100                 105                 110         


Lys Asp Gln Thr Lys Pro Thr Pro Leu Ile Leu Asp Glu Gln Gly Arg 
        115                 120                 125             


Thr Val Asp Ala Thr Gly Lys Glu Ile Glu Leu Thr His Arg Met Pro 
    130                 135                 140                 


Thr Leu Lys Ala Asn Ile Arg Ala Val Lys Arg Glu Gln Phe Lys Gln 
145                 150                 155                 160 


Gln Leu Lys Glu Lys Pro Ser Glu Asp Met Glu Ser Asn Thr Phe Phe 
                165                 170                 175     


Asp Pro Arg Val Ser Ile Ala Pro Ser Gln Arg Gln Arg Arg Thr Phe 
            180                 185                 190         


Lys Phe His Asp Lys Gly Lys Phe Glu Lys Ile Ala Gln Arg Leu Arg 
        195                 200                 205             


Thr Lys Ala Gln Leu Glu Lys Leu Gln Ala Glu Ile Ser Gln Ala Ala 
    210                 215                 220                 


Arg Lys Thr Gly Ile His Thr Ser Thr Arg Leu Ala Leu Ile Ala Pro 
225                 230                 235                 240 


Lys Lys Glu Leu Lys Glu Gly Asp Ile Pro Glu Ile Glu Trp Trp Asp 
                245                 250                 255     


Ser Tyr Ile Ile Pro Asn Gly Phe Asp Leu Gly Lys Ser Gln Glu Arg 
            260                 265                 270         


Arg Leu Phe Trp Asn His Lys Ser Cys 
        275                 280     


<210> 8916
<211> 230
<212> PRT
<213> Homo sapiens

<400> 8916
Met Arg Gly His Glu Ser Ser Val Phe Ser Ile Ser Val His Ala Ser 
1               5                   10                  15      


Gly Lys Tyr Ala Ile Thr Thr Ser Ser Asp Thr Ala Gln Leu Trp Asp 
            20                  25                  30          


Leu Asp Thr Phe Gln Arg Lys Arg Lys Leu Asn Ile Arg Gln Ser Val 
        35                  40                  45              


Gly Ile Gln Lys Val Phe Phe Leu Pro Leu Ser Asn Thr Ile Leu Ser 
    50                  55                  60                  


Cys Phe Lys Asp Asn Ser Ile Phe Ala Trp Glu Cys Asp Thr Leu Phe 
65                  70                  75                  80  


Cys Lys Tyr Gln Leu Pro Ala Pro Pro Glu Ser Ser Ser Ile Leu Tyr 
                85                  90                  95      


Lys Val Phe Ala Val Thr Arg Asp Gly Arg Ile Leu Ala Ala Gly Gly 
            100                 105                 110         


Lys Ser Asn His Leu His Leu Trp Cys Leu Glu Ala Arg Gln Leu Phe 
        115                 120                 125             


Arg Ile Ile Gln Met Pro Thr Lys Val Arg Ala Ile Arg His Leu Glu 
    130                 135                 140                 


Phe Leu Pro Asp Ser Phe Asp Ala Gly Ser Asn Gln Val Leu Gly Val 
145                 150                 155                 160 


Leu Ser Gln Asp Gly Ile Met Arg Phe Ile Asn Met Gln Thr Cys Lys 
                165                 170                 175     


Leu Leu Phe Glu Ile Gly Ser Leu Asp Glu Gly Ile Ser Ser Ser Ala 
            180                 185                 190         


Ile Ser Pro His Gly Arg Tyr Ile Ala Ser Ile Met Glu Asn Gly Ser 
        195                 200                 205             


Leu Asn Ile Tyr Ser Val Gln Ala Leu Thr Gln Glu Ile Asn Lys Glu 
    210                 215                 220                 


Glu Val Arg Ala Gln Asn 
225                 230 


<210> 8917
<211> 403
<212> PRT
<213> Homo sapiens

<400> 8917
Met Asp Ser Thr Met Asp Asp Ala Val Ala Gly Asp Phe Ala Leu Ile 
1               5                   10                  15      


Asn Lys Leu Asp Ile Gln Cys Asp Leu Lys Thr Leu Ser Asp Asp Ile 
            20                  25                  30          


Lys Glu Ser Leu Glu Ser Glu Gly Lys Asn Ser Lys Lys Glu Glu Pro 
        35                  40                  45              


Gln Glu Leu Leu Gln Ser Gln Asp Phe Val Gly Glu Lys Leu Gly Ser 
    50                  55                  60                  


Gly Glu Pro Ser His Ser Val Lys Val His Thr Val Pro Lys Pro Gly 
65                  70                  75                  80  


Lys Gly Ala Asp Leu Ser Lys Pro Pro Cys Arg Lys Ala Lys Glu Ile 
                85                  90                  95      


Arg Lys Glu Arg Lys Arg Leu Lys Leu Met Gln Gln Asn Pro Ala Gly 
            100                 105                 110         


Glu Leu Glu Gly Phe Gln Ala Gln Gly His Pro Pro Ser Leu Phe Pro 
        115                 120                 125             


Pro Lys Ala Lys Ser Asn Gln Pro Lys Ser Leu Glu Asp Leu Ile Phe 
    130                 135                 140                 


Glu Ser Leu Pro Glu Asn Ala Ser His Lys Leu Glu Val Arg Val Val 
145                 150                 155                 160 


Arg Ser Ser Pro Pro Ser Ser Gln Phe Lys Ala Thr Leu Leu Glu Ser 
                165                 170                 175     


Tyr Gln Val Tyr Lys Arg Tyr Gln Met Val Ile His Lys Asn Pro Pro 
            180                 185                 190         


Asp Thr Pro Thr Glu Ser Gln Phe Thr Arg Phe Leu Cys Ser Ser Pro 
        195                 200                 205             


Leu Glu Ala Glu Thr Pro Pro Asn Gly Pro Asp Cys Gly Tyr Gly Ser 
    210                 215                 220                 


Phe His Gln Gln Tyr Trp Leu Asp Gly Lys Ile Ile Ala Val Gly Val 
225                 230                 235                 240 


Ile Asp Ile Leu Pro Asn Cys Val Ser Ser Val Tyr Leu Tyr Tyr Asp 
                245                 250                 255     


Pro Asp Tyr Ser Phe Leu Ser Leu Gly Val Tyr Ser Ala Leu Arg Glu 
            260                 265                 270         


Ile Ala Phe Thr Arg Gln Leu His Glu Lys Thr Ser Gln Leu Ser Tyr 
        275                 280                 285             


Tyr Tyr Met Gly Phe Tyr Ile His Ser Cys Pro Lys Met Lys Tyr Lys 
    290                 295                 300                 


Gly Gln Tyr Arg Pro Ser Asp Leu Leu Cys Pro Glu Thr Tyr Val Trp 
305                 310                 315                 320 


Val Pro Ile Glu Gln Cys Leu Pro Ser Leu Glu Asn Ser Lys Tyr Cys 
                325                 330                 335     


Arg Phe Asn Gln Asp Pro Glu Ala Val Asp Glu Asp Arg Ser Thr Glu 
            340                 345                 350         


Pro Asp Arg Leu Gln Val Phe His Lys Arg Ala Ile Met Pro Tyr Gly 
        355                 360                 365             


Val Tyr Lys Lys Gln Gln Lys Asp Pro Ser Glu Glu Ala Ala Val Leu 
    370                 375                 380                 


Gln Tyr Ala Ser Leu Val Gly Gln Lys Cys Ser Glu Arg Met Leu Leu 
385                 390                 395                 400 


Phe Arg Asn 
            


<210> 8918
<211> 302
<212> PRT
<213> Homo sapiens

<400> 8918
Met Pro Leu Tyr Glu Gly Leu Gly Ser Gly Gly Glu Lys Thr Ala Val 
1               5                   10                  15      


Val Ile Asp Leu Gly Glu Ala Phe Thr Lys Cys Gly Phe Ala Gly Glu 
            20                  25                  30          


Thr Gly Pro Arg Cys Ile Ile Pro Ser Val Ile Lys Arg Ala Gly Met 
        35                  40                  45              


Pro Lys Pro Val Arg Val Val Gln Tyr Asn Ile Asn Thr Glu Glu Leu 
    50                  55                  60                  


Tyr Ser Tyr Leu Lys Glu Phe Ile His Ile Leu Tyr Phe Arg His Leu 
65                  70                  75                  80  


Leu Val Asn Pro Arg Asp Arg Arg Val Val Ile Ile Glu Ser Val Leu 
                85                  90                  95      


Cys Pro Ser His Phe Arg Glu Thr Leu Thr Arg Val Leu Phe Lys Tyr 
            100                 105                 110         


Phe Glu Val Pro Ser Val Leu Leu Ala Pro Ser His Leu Met Ala Leu 
        115                 120                 125             


Leu Thr Leu Gly Ile Asn Ser Ala Met Val Leu Asp Cys Gly Tyr Arg 
    130                 135                 140                 


Glu Ser Leu Val Leu Pro Ile Tyr Glu Gly Ile Pro Val Leu Asn Cys 
145                 150                 155                 160 


Trp Gly Ala Leu Pro Leu Gly Gly Lys Ala Leu His Lys Glu Leu Glu 
                165                 170                 175     


Thr Gln Leu Leu Glu Gln Cys Thr Val Asp Thr Ser Val Ala Lys Glu 
            180                 185                 190         


Gln Ser Leu Pro Ser Val Met Gly Ser Val Pro Glu Gly Val Leu Glu 
        195                 200                 205             


Asp Ile Lys Ala Arg Thr Cys Phe Val Ser Asp Leu Lys Arg Gly Leu 
    210                 215                 220                 


Lys Ile Gln Ala Ala Lys Phe Asn Ile Asp Gly Asn Asn Glu Arg Pro 
225                 230                 235                 240 


Ser Pro Pro Pro Asn Val Asp Tyr Pro Leu Asp Gly Glu Lys Ile Leu 
                245                 250                 255     


His Ile Leu Gly Ser Ile Arg Asp Ser Val Val Glu Ile Leu Phe Glu 
            260                 265                 270         


Gln Asp Asn Glu Glu Gln Ser Val Ala Thr Leu Ile Leu Asp Ser Leu 
        275                 280                 285             


Ile Gln Cys Cys Ser Cys Cys Pro Gly Trp Ser Ala Met Ala 
    290                 295                 300         


<210> 8919
<211> 125
<212> PRT
<213> Homo sapiens

<400> 8919
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser 
        115                 120                 125 


<210> 8920
<211> 386
<212> PRT
<213> Homo sapiens

<400> 8920
Met Ala Asp Ser Leu Glu Ser Thr Pro Leu Pro Ser Pro Glu Asp Arg 
1               5                   10                  15      


Leu Ala Lys Leu His Pro Ser Lys Glu Leu Leu Glu Tyr Tyr Gln Lys 
            20                  25                  30          


Lys Met Ala Glu Cys Glu Ala Glu Asn Glu Asp Leu Leu Lys Lys Leu 
        35                  40                  45              


Glu Leu Tyr Lys Glu Ala Cys Glu Gly Gln His Lys Leu Glu Cys Asp 
    50                  55                  60                  


Leu Gln Gln Arg Glu Glu Glu Ile Ala Glu Leu Gln Lys Ala Leu Ser 
65                  70                  75                  80  


Asp Met Gln Val Cys Leu Phe Gln Glu Arg Glu His Val Leu Arg Leu 
                85                  90                  95      


Tyr Ser Glu Asn Asp Arg Leu Arg Ile Arg Glu Leu Glu Asp Lys Lys 
            100                 105                 110         


Lys Ile Gln Asn Leu Leu Ala Leu Val Gly Thr Asp Ala Gly Glu Val 
        115                 120                 125             


Thr Tyr Phe Cys Lys Glu Pro Pro His Lys Val Thr Ile Leu Gln Lys 
    130                 135                 140                 


Thr Ile Gln Ala Val Gly Glu Cys Glu Gln Ser Glu Ser Ser Ala Phe 
145                 150                 155                 160 


Lys Ala Asp Pro Lys Ile Ser Lys Arg Arg Pro Ser Arg Glu Arg Lys 
                165                 170                 175     


Glu Ser Ser Glu His Tyr Gln Arg Asp Ile Gln Thr Leu Ile Leu Gln 
            180                 185                 190         


Val Glu Ala Leu Gln Ala Gln Leu Gly Glu Gln Thr Lys Leu Ser Arg 
        195                 200                 205             


Glu Gln Ile Glu Gly Leu Ile Glu Asp Arg Arg Ile His Leu Glu Glu 
    210                 215                 220                 


Ile Gln Val Gln His Gln Arg Asn Gln Asn Lys Ile Lys Glu Leu Thr 
225                 230                 235                 240 


Lys Asn Leu His His Thr Gln Glu Leu Leu Tyr Glu Ser Thr Lys Asp 
                245                 250                 255     


Phe Leu Gln Leu Arg Ser Glu Asn Gln Asn Lys Glu Lys Ser Trp Met 
            260                 265                 270         


Leu Glu Lys Asp Asn Leu Met Ser Lys Ile Lys Gln Tyr Arg Val Gln 
        275                 280                 285             


Cys Lys Lys Lys Glu Asp Lys Ile Gly Lys Val Leu Pro Val Met His 
    290                 295                 300                 


Glu Ser His His Ala Gln Ser Glu Tyr Ile Lys Ser Leu Lys Asp Lys 
305                 310                 315                 320 


Leu Val Gln Glu Lys Lys Leu Ser Asn Met Tyr Gln Glu Gln Cys Ile 
                325                 330                 335     


Ser Leu Glu Glu Glu Leu Ala Arg Ile Arg Glu Glu Glu Gly Met Arg 
            340                 345                 350         


Arg Glu Ile Phe Lys Asp Arg Thr Asn Lys Met Gly Lys Arg Leu Gln 
        355                 360                 365             


Ile Met Thr Lys Arg Tyr Glu Ala Leu Glu Arg Arg Arg Ile Leu Glu 
    370                 375                 380                 


Val Glu 
385     


<210> 8921
<211> 332
<212> PRT
<213> Homo sapiens

<400> 8921
Met Glu Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly 
1               5                   10                  15      


Pro Leu Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys 
            20                  25                  30          


Gly Leu Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys 
        35                  40                  45              


Ala Ala Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu Ala Asp 
    50                  55                  60                  


Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr 
65                  70                  75                  80  


Phe Val Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser 
                85                  90                  95      


Ala Tyr Asp Phe Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile 
            100                 105                 110         


Glu Leu Ala Lys Gly Glu Pro Pro Asn Ser Asp Leu His Pro Met Arg 
        115                 120                 125             


Val Leu Phe Leu Ile Pro Lys Asn Ser Pro Pro Thr Leu Glu Gly Gln 
    130                 135                 140                 


His Ser Lys Pro Phe Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Asp 
145                 150                 155                 160 


Pro Arg Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile 
                165                 170                 175     


Thr Arg Tyr Thr Lys Lys Thr Ser Phe Leu Thr Glu Leu Ile Asp Arg 
            180                 185                 190         


Tyr Lys Arg Trp Lys Ser Glu Gly His Gly Glu Glu Ser Ser Ser Glu 
        195                 200                 205             


Asp Ser Asp Ile Asp Gly Glu Ala Glu Asp Gly Glu Gln Gly Pro Ile 
    210                 215                 220                 


Trp Thr Phe Pro Pro Thr Ile Arg Pro Ser Pro His Ser Lys Leu His 
225                 230                 235                 240 


Lys Gly Thr Ala Leu His Ser Ser Gln Lys Pro Ala Glu Pro Val Lys 
                245                 250                 255     


Arg Gln Pro Arg Ser Gln Cys Leu Ser Thr Leu Val Arg Pro Val Phe 
            260                 265                 270         


Gly Glu Leu Lys Glu Lys His Lys Gln Ser Gly Gly Ser Val Gly Ala 
        275                 280                 285             


Leu Glu Glu Leu Glu Asn Ala Phe Ser Leu Ala Glu Glu Ser Cys Pro 
    290                 295                 300                 


Gly Ile Ser Asp Lys Leu Met Val His Leu Val Glu Arg Val Gln Arg 
305                 310                 315                 320 


Phe Ser His Asn Arg Asn His Leu Thr Ser Thr Arg 
                325                 330         


<210> 8922
<211> 507
<212> PRT
<213> Homo sapiens

<400> 8922
Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu Val Leu Glu 
1               5                   10                  15      


Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu Gln Ala Pro 
            20                  25                  30          


Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly Leu Leu Leu 
        35                  40                  45              


Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu Gln Ala Gln 
    50                  55                  60                  


Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu Met His Gln Pro Lys 
65                  70                  75                  80  


Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly Ala Leu Gln Gln Gly 
                85                  90                  95      


Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu Gln Gln Leu Arg Ala 
            100                 105                 110         


Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg Gly Pro Asp Gly Val 
        115                 120                 125             


Cys Leu Ser Gly Gly Arg Gly Pro Gln Gly Asp Lys Ala Ile Arg Glu 
    130                 135                 140                 


Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser Phe Leu Lys Gln Lys 
145                 150                 155                 160 


Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg Gln Glu Leu Glu Arg 
                165                 170                 175     


Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp Leu Glu Arg Ser Leu 
            180                 185                 190         


Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala Gly Leu Ala Glu Leu 
        195                 200                 205             


Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu Glu Asn Trp Gly Gln 
    210                 215                 220                 


Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala Trp His Gln Lys Ser 
225                 230                 235                 240 


His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys Glu Lys Trp Trp Asp 
                245                 250                 255     


Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys His Lys Lys Glu Glu 
            260                 265                 270         


Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly Gln Glu Asp Arg Glu 
        275                 280                 285             


Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg Val Glu Glu Ser Gly 
    290                 295                 300                 


Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys Glu Pro Pro Arg Lys 
305                 310                 315                 320 


Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln Lys Gln Pro Arg Trp 
                325                 330                 335     


Arg Glu Gly Thr Lys Asp Ser His Asp Pro Leu Pro Ser Trp Ala Glu 
            340                 345                 350         


Leu Leu Arg Pro Lys Tyr Arg Ala Pro Gln Gly Cys Ser Gly Val Asp 
        355                 360                 365             


Glu Cys Ala Arg Gln Glu Gly Leu Thr Phe Phe Gly Thr Glu Leu Ala 
    370                 375                 380                 


Pro Val Arg Gln Gln Glu Leu Ala Ser Leu Leu Arg Thr Tyr Leu Ala 
385                 390                 395                 400 


Arg Leu Pro Trp Ala Gly Gln Leu Thr Lys Glu Leu Pro Leu Ser Pro 
                405                 410                 415     


Ala Phe Phe Gly Glu Asp Gly Ile Phe Arg His Asp Arg Leu Arg Phe 
            420                 425                 430         


Arg Asp Phe Val Asp Ala Leu Glu Asp Ser Leu Glu Glu Val Ala Val 
        435                 440                 445             


Gln Gln Thr Gly Asp Asp Asp Glu Val Asp Asp Phe Glu Asp Phe Ile 
    450                 455                 460                 


Phe Ser His Phe Phe Gly Asp Lys Ala Leu Lys Lys Arg Ser Gly Lys 
465                 470                 475                 480 


Lys Asp Lys His Ser Gln Ser Pro Arg Ala Ala Gly Pro Arg Glu Gly 
                485                 490                 495     


His Ser His Ser His His His His His Arg Gly 
            500                 505         


<210> 8923
<211> 823
<212> PRT
<213> Homo sapiens

<400> 8923
Met Thr Leu Leu Ser Ser Gln Ser Ser Ser Leu Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Val Ser Ala Glu Asn Pro Glu Gln Arg Met Leu Glu Lys Arg Ala 
            20                  25                  30          


Lys Val Ile Glu Glu Leu Leu Gln Thr Glu Arg Asp Tyr Ile Arg Asp 
        35                  40                  45              


Leu Glu Met Cys Ile Glu Arg Ile Met Val Pro Met Gln Gln Ala Gln 
    50                  55                  60                  


Val Pro Asn Ile Asp Phe Glu Gly Leu Phe Gly Asn Met Gln Met Val 
65                  70                  75                  80  


Ile Lys Val Ser Lys Gln Leu Leu Ala Ala Leu Glu Ile Ser Asp Ala 
                85                  90                  95      


Val Gly Pro Val Phe Leu Gly His Arg Asp Glu Leu Glu Gly Thr Tyr 
            100                 105                 110         


Lys Ile Tyr Cys Gln Asn His Asp Glu Ala Ile Ala Leu Leu Glu Ile 
        115                 120                 125             


Tyr Glu Lys Asp Glu Lys Ile Gln Lys His Leu Gln Asp Ser Leu Ala 
    130                 135                 140                 


Asp Leu Lys Ser Leu Tyr Asn Glu Trp Gly Cys Thr Asn Tyr Ile Asn 
145                 150                 155                 160 


Leu Gly Ser Phe Leu Ile Lys Pro Val Gln Arg Val Met Arg Tyr Pro 
                165                 170                 175     


Leu Leu Leu Met Glu Leu Leu Asn Ser Thr Pro Glu Ser His Pro Asp 
            180                 185                 190         


Lys Val Pro Leu Thr Asn Ala Val Leu Ala Val Lys Glu Ile Asn Val 
        195                 200                 205             


Asn Ile Asn Glu Tyr Lys Arg Arg Lys Asp Leu Val Leu Lys Tyr Arg 
    210                 215                 220                 


Lys Gly Asp Glu Asp Ser Leu Met Glu Lys Ile Ser Lys Leu Asn Ile 
225                 230                 235                 240 


His Ser Ile Ile Lys Lys Ser Asn Arg Val Ser Ser His Leu Lys His 
                245                 250                 255     


Leu Thr Gly Phe Ala Pro Gln Ile Lys Asp Glu Val Phe Glu Glu Thr 
            260                 265                 270         


Glu Lys Asn Phe Arg Met Gln Glu Arg Leu Ile Lys Ser Phe Ile Arg 
        275                 280                 285             


Asp Leu Ser Leu Tyr Leu Gln His Ile Arg Glu Ser Ala Cys Val Lys 
    290                 295                 300                 


Val Val Ala Ala Val Ser Met Trp Asp Val Cys Met Glu Arg Gly His 
305                 310                 315                 320 


Arg Asp Leu Glu Gln Phe Glu Arg Val His Arg Tyr Ile Ser Asp Gln 
                325                 330                 335     


Leu Phe Thr Asn Phe Lys Glu Arg Thr Glu Arg Leu Val Ile Ser Pro 
            340                 345                 350         


Leu Asn Gln Leu Leu Ser Met Phe Thr Gly Pro His Lys Leu Val Gln 
        355                 360                 365             


Lys Arg Phe Asp Lys Leu Leu Asp Phe Tyr Asn Cys Thr Glu Arg Ala 
    370                 375                 380                 


Glu Lys Leu Lys Asp Lys Lys Thr Leu Glu Glu Leu Gln Ser Ala Arg 
385                 390                 395                 400 


Asn Asn Tyr Glu Ala Leu Asn Ala Gln Leu Leu Asp Glu Leu Pro Lys 
                405                 410                 415     


Phe His Gln Tyr Ala Gln Gly Leu Phe Thr Asn Cys Val His Gly Tyr 
            420                 425                 430         


Ala Glu Ala His Cys Asp Phe Val His Gln Ala Leu Glu Gln Leu Lys 
        435                 440                 445             


Pro Leu Leu Ser Leu Leu Lys Val Ala Gly Arg Glu Gly Asn Leu Ile 
    450                 455                 460                 


Ala Ile Phe His Glu Glu His Ser Arg Val Leu Gln Gln Leu Gln Val 
465                 470                 475                 480 


Phe Thr Phe Phe Pro Glu Ser Leu Pro Ala Thr Lys Lys Pro Phe Glu 
                485                 490                 495     


Arg Lys Thr Ile Asp Arg Gln Ser Ala Arg Lys Pro Leu Leu Gly Leu 
            500                 505                 510         


Pro Ser Tyr Met Leu Gln Ser Glu Glu Leu Arg Ala Ser Leu Leu Ala 
        515                 520                 525             


Arg Tyr Pro Pro Glu Lys Leu Phe Gln Ala Glu Arg Asn Phe Asn Ala 
    530                 535                 540                 


Ala Gln Asp Leu Asp Val Ser Leu Leu Glu Gly Asp Leu Val Gly Val 
545                 550                 555                 560 


Ile Lys Lys Lys Asp Pro Met Gly Ser Gln Asn Arg Trp Leu Ile Asp 
                565                 570                 575     


Asn Gly Val Thr Lys Gly Phe Val Tyr Ser Ser Phe Leu Lys Pro Tyr 
            580                 585                 590         


Asn Pro Arg Arg Ser His Ser Asp Ala Ser Val Gly Ser His Ser Ser 
        595                 600                 605             


Thr Glu Ser Glu His Gly Ser Ser Ser Pro Arg Phe Pro Arg Gln Asn 
    610                 615                 620                 


Ser Gly Ser Thr Leu Thr Phe Asn Pro Ser Ser Met Ala Val Ser Phe 
625                 630                 635                 640 


Thr Ser Gly Ser Cys Gln Lys Gln Pro Gln Asp Ala Ser Pro Pro Pro 
                645                 650                 655     


Lys Glu Cys Asp Gln Gly Thr Leu Ser Ala Ser Leu Asn Pro Ser Asn 
            660                 665                 670         


Ser Glu Ser Ser Pro Ser Arg Cys Pro Ser Asp Pro Asp Ser Thr Ser 
        675                 680                 685             


Gln Pro Arg Ser Gly Asp Ser Ala Asp Val Ala Arg Asp Val Lys Gln 
    690                 695                 700                 


Pro Thr Ala Thr Pro Arg Ser Tyr Arg Asn Phe Arg His Pro Glu Ile 
705                 710                 715                 720 


Val Gly Tyr Ser Val Pro Gly Arg Asn Gly Gln Ser Gln Asp Leu Val 
                725                 730                 735     


Lys Gly Cys Ala Arg Thr Ala Gln Ala Pro Glu Asp Arg Ser Thr Glu 
            740                 745                 750         


Pro Asp Gly Ser Glu Ala Glu Gly Asn Gln Val Tyr Phe Ala Val Tyr 
        755                 760                 765             


Thr Phe Lys Ala Arg Asn Pro Asn Glu Leu Ser Val Ser Ala Asn Gln 
    770                 775                 780                 


Lys Leu Lys Ile Leu Glu Phe Lys Asp Val Thr Gly Asn Thr Glu Trp 
785                 790                 795                 800 


Trp Leu Ala Glu Val Asn Gly Lys Lys Gly Tyr Val Pro Ser Asn Tyr 
                805                 810                 815     


Ile Arg Lys Thr Glu Tyr Thr 
            820             


<210> 8924
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 8924
Xaa Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu Cys Lys 
1               5                   10                  15      


Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys Gln 
            20                  25                  30          


Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser Val 
        35                  40                  45              


Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser Thr 
    50                  55                  60                  


Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile Ser 
65                  70                  75                  80  


Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys Glu 
                85                  90                  95      


Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn Pro 
            100                 105                 110         


Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn Thr 
        115                 120                 125             


Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser Thr 
    130                 135                 140                 


Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu Ser 
145                 150                 155                 160 


Gln Lys Gln 
            


<210> 8925
<211> 256
<212> PRT
<213> Homo sapiens

<400> 8925
Met Ala Thr Gln Arg Lys His Leu Val Lys Asp Phe Asn Pro Tyr Ile 
1               5                   10                  15      


Thr Cys Tyr Ile Cys Lys Gly Tyr Leu Ile Lys Pro Thr Thr Val Thr 
            20                  25                  30          


Glu Cys Leu His Thr Phe Cys Lys Thr Cys Ile Val Gln His Phe Glu 
        35                  40                  45              


Asp Ser Asn Asp Cys Pro Arg Cys Gly Asn Gln Val His Glu Thr Asn 
    50                  55                  60                  


Pro Leu Glu Met Leu Arg Leu Asp Asn Thr Leu Glu Glu Ile Ile Phe 
65                  70                  75                  80  


Lys Leu Val Pro Gly Leu Arg Glu Gln Glu Leu Glu Arg Glu Ser Glu 
                85                  90                  95      


Phe Trp Lys Lys Asn Lys Pro Gln Glu Asn Gly Gln Asp Asp Thr Ser 
            100                 105                 110         


Lys Ala Asp Lys Pro Lys Val Asp Glu Glu Gly Asp Glu Asn Glu Asp 
        115                 120                 125             


Asp Lys Asp Tyr His Arg Ser Asp Pro Gln Ile Ala Ile Cys Leu Asp 
    130                 135                 140                 


Cys Leu Arg Asn Asn Gly Gln Ser Gly Asp Asn Val Val Lys Gly Leu 
145                 150                 155                 160 


Met Lys Lys Phe Ile Arg Cys Ser Thr Arg Val Thr Val Gly Thr Ile 
                165                 170                 175     


Lys Lys Phe Leu Ser Leu Lys Leu Lys Leu Pro Ser Ser Tyr Glu Leu 
            180                 185                 190         


Asp Val Leu Cys Asn Gly Glu Ile Met Gly Lys Asp His Thr Met Glu 
        195                 200                 205             


Phe Ile Tyr Met Thr Arg Trp Arg Leu Arg Gly Glu Asn Phe Arg Cys 
    210                 215                 220                 


Leu Asn Cys Ser Ala Ser Gln Val Cys Ser Gln Asp Gly Pro Leu Tyr 
225                 230                 235                 240 


Gln Ser Tyr Pro Met Val Leu Gln Tyr Arg Pro Arg Ile Asp Phe Gly 
                245                 250                 255     


<210> 8926
<211> 930
<212> PRT
<213> Homo sapiens

<400> 8926
Met Ser Glu Phe Arg Ile His His Asp Val Asn Glu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Arg Val His Gly Gly Asp Gly Ala Glu Val Tyr Ile Asp Leu Leu 
            20                  25                  30          


Gln Lys Asn Arg Thr Pro Tyr Val Thr Thr Thr Val Ser Ala His Ser 
        35                  40                  45              


Ala Lys Val Lys Ile Ala Glu Phe Ser Arg Thr Pro Glu Asp Phe Leu 
    50                  55                  60                  


Lys Lys Tyr Asp Glu Leu Lys Ser Lys Asn Thr Arg Asn Leu Asp Pro 
65                  70                  75                  80  


Leu Val Tyr Leu Leu Ser Lys Leu Thr Glu Asp Lys Glu Thr Leu Gln 
                85                  90                  95      


Tyr Leu Gln Gln Asn Ala Lys Glu Arg Ala Glu Leu Ala Ala Ala Ala 
            100                 105                 110         


Val Gly Ser Ser Thr Thr Ser Ile Asn Val Pro Ala Ala Ala Ser Lys 
        115                 120                 125             


Ile Ser Met Gln Glu Leu Glu Glu Leu Arg Lys Gln Leu Gly Ser Val 
    130                 135                 140                 


Ala Thr Gly Ser Thr Leu Gln Gln Ser Leu Glu Leu Lys Arg Lys Met 
145                 150                 155                 160 


Leu Arg Asp Lys Gln Asn Lys Lys Asn Ser Gly Gln His Leu Pro Ile 
                165                 170                 175     


Phe Pro Ala Trp Val Tyr Glu Arg Pro Ala Leu Ile Gly Asp Phe Leu 
            180                 185                 190         


Ile Gly Ala Gly Ile Ser Thr Asp Thr Ala Leu Pro Ile Val Leu Leu 
        195                 200                 205             


Arg Trp Asn Leu Ala Leu Ser Pro Arg Leu Lys Cys Ser Gly Val Ile 
    210                 215                 220                 


Ser Ala His Cys Asn Leu His Leu Pro Gly Thr Leu Pro Leu Ala Ser 
225                 230                 235                 240 


Gln Glu Ser Ala Val Val Glu Asp Leu Leu Tyr Val Leu Val Gly Val 
                245                 250                 255     


Asp Gly Arg Tyr Val Ser Ala Gln Pro Leu Ala Gly Arg Gln Ser Arg 
            260                 265                 270         


Thr Phe Leu Val Asp Pro Asn Leu Asp Leu Ser Ile Arg Glu Leu Val 
        275                 280                 285             


His Arg Ile Leu Pro Val Ala Ala Ser Tyr Ser Ala Val Thr Arg Phe 
    290                 295                 300                 


Ile Glu Glu Lys Ser Ser Phe Glu Tyr Gly Gln Val Asn His Ala Leu 
305                 310                 315                 320 


Ala Ala Ala Met Arg Thr Leu Val Lys Glu His Leu Ile Leu Val Ser 
                325                 330                 335     


Gln Leu Glu Gln Leu His Arg Gln Gly Leu Leu Ser Leu Gln Lys Leu 
            340                 345                 350         


Trp Phe Tyr Ile Gln Pro Ala Met Arg Thr Met Asp Ile Leu Ala Ser 
        355                 360                 365             


Leu Ala Thr Ser Val Asp Lys Gly Glu Cys Leu Gly Gly Ser Thr Leu 
    370                 375                 380                 


Ser Leu Leu His Asp Arg Ser Phe Ser Tyr Thr Gly Asp Ser Gln Ala 
385                 390                 395                 400 


Gln Glu Leu Cys Leu Tyr Leu Thr Lys Ala Ala Ser Ala Pro Tyr Phe 
                405                 410                 415     


Glu Val Leu Glu Lys Trp Ile Tyr Arg Gly Ile Ile His Asp Pro Tyr 
            420                 425                 430         


Ser Glu Phe Met Val Glu Glu His Glu Leu Arg Lys Glu Arg Ile Gln 
        435                 440                 445             


Glu Asp Tyr Asn Asp Lys Tyr Trp Asp Gln Arg Tyr Thr Ile Val Gln 
    450                 455                 460                 


Gln Gln Ile Pro Ser Phe Leu Gln Lys Met Ala Asp Lys Ile Leu Ser 
465                 470                 475                 480 


Thr Gly Lys Tyr Leu Asn Val Val Arg Glu Cys Gly His Asp Val Thr 
                485                 490                 495     


Cys Pro Val Ala Lys Glu Ile Ile Tyr Thr Leu Lys Glu Arg Ala Tyr 
            500                 505                 510         


Val Glu Gln Ile Glu Lys Ala Phe Asn Tyr Ala Ser Lys Val Leu Leu 
        515                 520                 525             


Asp Phe Leu Met Glu Glu Lys Glu Leu Val Ala His Leu Arg Ser Ile 
    530                 535                 540                 


Lys Arg Tyr Phe Leu Met Asp Gln Gly Asp Phe Phe Val His Phe Met 
545                 550                 555                 560 


Asp Leu Ala Glu Glu Glu Leu Arg Lys Pro Val Glu Asp Ile Thr Pro 
                565                 570                 575     


Pro Arg Leu Glu Ala Leu Leu Glu Leu Ala Leu Arg Met Ser Thr Ala 
            580                 585                 590         


Asn Thr Asp Pro Phe Lys Asp Asp Leu Lys Ile Asp Leu Met Pro His 
        595                 600                 605             


Asp Leu Ile Thr Gln Leu Leu Arg Val Leu Ala Ile Glu Thr Lys Gln 
    610                 615                 620                 


Glu Lys Ala Met Ala His Ala Asp Pro Thr Glu Leu Ala Leu Ser Gly 
625                 630                 635                 640 


Leu Glu Ala Phe Ser Phe Asp Tyr Ile Val Lys Trp Pro Leu Ser Leu 
                645                 650                 655     


Ile Ile Asn Arg Lys Ala Leu Thr Arg Tyr Gln Met Leu Phe Arg His 
            660                 665                 670         


Met Phe Tyr Cys Lys His Val Glu Arg Gln Leu Cys Ser Val Trp Ile 
        675                 680                 685             


Ser Asn Lys Thr Ala Lys Gln His Ser Leu His Ser Ala Gln Trp Phe 
    690                 695                 700                 


Ala Gly Ala Phe Thr Leu Arg Gln Arg Met Leu Asn Phe Val Gln Asn 
705                 710                 715                 720 


Ile Gln Tyr Tyr Met Met Phe Glu Val Met Glu Pro Thr Trp His Ile 
                725                 730                 735     


Leu Glu Lys Asn Leu Lys Ser Ala Ser Asn Ile Asp Asp Val Leu Gly 
            740                 745                 750         


His His Thr Gly Phe Leu Asp Thr Cys Leu Lys Asp Cys Met Leu Thr 
        755                 760                 765             


Asn Pro Glu Leu Leu Lys Val Phe Ser Lys Leu Met Ser Val Cys Val 
    770                 775                 780                 


Met Phe Thr Asn Cys Met Gln Lys Phe Thr Gln Ser Met Lys Leu Asp 
785                 790                 795                 800 


Gly Glu Leu Gly Gly Gln Thr Leu Glu His Ser Thr Val Leu Gly Leu 
                805                 810                 815     


Pro Ala Gly Ala Glu Glu Arg Ala Arg Lys Glu Leu Ala Arg Lys His 
            820                 825                 830         


Leu Ala Glu His Ala Asp Thr Val Gln Leu Val Ser Gly Phe Glu Ala 
        835                 840                 845             


Thr Ile Asn Lys Phe Asp Lys Asn Phe Ser Ala His Leu Leu Asp Leu 
    850                 855                 860                 


Leu Ala Arg Leu Ser Ile Tyr Ser Thr Ser Asp Cys Glu His Gly Met 
865                 870                 875                 880 


Ala Ser Val Ile Ser Arg Leu Asp Phe Asn Gly Phe Tyr Thr Glu Arg 
                885                 890                 895     


Leu Glu Arg Leu Ser Ala Glu Arg Ser Gln Lys Ala Thr Pro Gln Val 
            900                 905                 910         


Pro Val Leu Arg Gly Pro Pro Ala Pro Ala Pro Arg Val Ala Val Thr 
        915                 920                 925             


Ala Gln 
    930 


<210> 8927
<211> 42
<212> PRT
<213> Homo sapiens

<400> 8927
Met Cys Leu Leu Pro Ile Arg Val Lys Glu Ala Glu Glu Val Cys Arg 
1               5                   10                  15      


Gln Lys Lys Gly Lys Ser Leu Tyr Lys Ile Lys Pro Arg His Asp Ser 
            20                  25                  30          


Gly Ile Lys Ala Lys Ile Ser Met Lys Thr 
        35                  40          


<210> 8928
<211> 151
<212> PRT
<213> Homo sapiens

<400> 8928
Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe 
1               5                   10                  15      


Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser 
            20                  25                  30          


Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu 
        35                  40                  45              


Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr 
    50                  55                  60                  


Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg 
65                  70                  75                  80  


Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly 
            100                 105                 110         


Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln 
        115                 120                 125             


Asp Val Thr Ala Thr Ser Ala Arg Ser Lys Leu Leu Ala Ala Glu Thr 
    130                 135                 140                 


Glu Leu Leu Cys Leu Leu Tyr 
145                 150     


<210> 8929
<211> 208
<212> PRT
<213> Homo sapiens

<400> 8929
Met Ser Ala Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
1               5                   10                  15      


Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
            20                  25                  30          


Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
        35                  40                  45              


Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Val Arg Leu 
    50                  55                  60                  


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
65                  70                  75                  80  


Ser Tyr Ile Arg Asp Ser Thr Val Ala Val Val Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Leu Asn Ser Phe Gln Gln Thr Ser Lys Trp Ile Asp Asp Val Arg 
            100                 105                 110         


Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
        115                 120                 125             


Asp Leu Ala Asp Lys Arg Gln Ile Thr Ile Glu Glu Gly Glu Gln Arg 
    130                 135                 140                 


Ala Lys Glu Leu Ser Val Met Phe Ile Glu Thr Ser Ala Lys Thr Gly 
145                 150                 155                 160 


Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ser Ala Leu Pro Gly 
                165                 170                 175     


Met Glu Asn Val Gln Glu Lys Ser Lys Glu Gly Met Ile Asp Ile Lys 
            180                 185                 190         


Leu Asp Lys Pro Gln Glu Pro Pro Ala Ser Glu Gly Gly Cys Ser Cys 
        195                 200                 205             


<210> 8930
<211> 524
<212> PRT
<213> Homo sapiens

<400> 8930
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met 
1               5                   10                  15      


Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro 
            20                  25                  30          


Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro 
        35                  40                  45              


Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His 
    50                  55                  60                  


Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile 
65                  70                  75                  80  


Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile 
                85                  90                  95      


Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val 
            100                 105                 110         


Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile 
        115                 120                 125             


Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp 
    130                 135                 140                 


Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr 
145                 150                 155                 160 


Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His 
                165                 170                 175     


Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile 
            180                 185                 190         


Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly 
        195                 200                 205             


Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu 
    210                 215                 220                 


Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala 
225                 230                 235                 240 


Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp 
                245                 250                 255     


Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn 
            260                 265                 270         


Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys 
        275                 280                 285             


Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln 
    290                 295                 300                 


Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His 
305                 310                 315                 320 


Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala 
                325                 330                 335     


Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu 
            340                 345                 350         


Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg 
        355                 360                 365             


Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr 
    370                 375                 380                 


Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys 
385                 390                 395                 400 


Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His 
                405                 410                 415     


Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser 
            420                 425                 430         


Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn 
        435                 440                 445             


Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu 
    450                 455                 460                 


Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met 
465                 470                 475                 480 


Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser 
                485                 490                 495     


Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp 
            500                 505                 510         


Leu Tyr Gln Gln Lys Ile Lys Lys Glu Arg Lys Lys 
        515                 520                 


<210> 8931
<211> 415
<212> PRT
<213> Homo sapiens

<400> 8931
Met Met Leu Gly Pro Glu Gly Gly Glu Gly Phe Val Val Lys Leu Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Val Glu Asp Val Gln Asn Phe Leu Ser 
            20                  25                  30          


Asp Cys Thr Ile His Asp Gly Ala Ala Gly Val His Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Gln Ser Gly Glu Ala Phe Val Glu Leu Gly Ser Glu 
    50                  55                  60                  


Asp Asp Val Lys Met Ala Leu Lys Lys Asp Arg Glu Ser Met Gly His 
65                  70                  75                  80  


Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu Glu Val Arg 
            180                 185                 190         


Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly Ile Val Lys 
    210                 215                 220                 


Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser Thr Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr Gly Phe Thr 
                245                 250                 255     


Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser Gly Met Tyr 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr Gly Ala Ser 
        355                 360                 365             


Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly Val Ser Ala 
    370                 375                 380                 


Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val Ser Gly Cys 
385                 390                 395                 400 


Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly Tyr Asp 
                405                 410                 415 


<210> 8932
<211> 503
<212> PRT
<213> Homo sapiens

<400> 8932
Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser Val 
        115                 120                 125             


Tyr Leu Ser Tyr Glu Lys Arg Ala Glu Thr Leu Ala Val Glu Ile Lys 
    130                 135                 140                 


Glu Leu Gln Gly Gln Leu Ala Asp Tyr Asn Met Leu Val Asp Lys Leu 
145                 150                 155                 160 


Asn Thr Asn Thr Glu Met Glu Glu Val Met Asn Asp Tyr Asn Met Leu 
                165                 170                 175     


Lys Ala Gln Asn Asp Arg Glu Thr Gln Ser Leu Asp Val Ile Phe Thr 
            180                 185                 190         


Glu Arg Gln Ala Lys Glu Lys Gln Ile Arg Ser Val Glu Glu Glu Ile 
        195                 200                 205             


Glu Gln Glu Lys Gln Ala Thr Asp Asp Ile Ile Lys Asn Met Ser Phe 
    210                 215                 220                 


Glu Asn Gln Val Lys Tyr Leu Glu Met Lys Thr Thr Asn Glu Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Asp Thr Leu Gln Gln Gln Leu Asp Ser Gln Asn Met 
                245                 250                 255     


Lys Lys Glu Ser Leu Glu Ala Glu Ile Ala His Ser Gln Val Lys Gln 
            260                 265                 270         


Glu Ala Val Leu Leu His Glu Lys Leu Tyr Glu Leu Glu Ser His Arg 
        275                 280                 285             


Asp Gln Met Ile Ala Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala 
305                 310                 315                 320 


Ser Met Glu Arg Gln Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe 
                325                 330                 335     


Ile Glu Glu Ile Arg Gln Leu Asp Met Asp Leu Glu Glu His Gln Gly 
            340                 345                 350         


Glu Met Asn Gln Lys Tyr Lys Glu Leu Lys Lys Arg Glu Glu His Met 
        355                 360                 365             


Asp Thr Phe Ile Glu Thr Phe Glu Glu Thr Lys Asn Gln Glu Leu Lys 
    370                 375                 380                 


Arg Lys Ala Gln Ile Glu Ala Asn Ile Val Ala Leu Leu Glu His Cys 
385                 390                 395                 400 


Ser Arg Asn Ile Asn Arg Ile Glu Gln Ile Ser Ser Ile Thr Asn Gln 
                405                 410                 415     


Glu Leu Lys Met Met Gln Asp Asp Leu Asn Phe Lys Ser Thr Glu Val 
            420                 425                 430         


Gln Lys Ser Gln Ser Thr Ala Gln Asn Leu Thr Ser Asp Ile Gln Arg 
        435                 440                 445             


Leu Gln Leu Asp Leu Gln Lys Met Glu Leu Leu Glu Ser Lys Met Thr 
    450                 455                 460                 


Glu Glu Gln His Ser Leu Lys Ser Lys Ile Lys Gln Met Thr Thr Asp 
465                 470                 475                 480 


Leu Glu Ile Tyr Asn Asp Leu Pro Ala Leu Lys Ser Ser Gly Glu Lys 
                485                 490                 495     


Lys Lys Lys Lys Lys Lys Lys 
            500             


<210> 8933
<211> 486
<212> PRT
<213> Homo sapiens

<400> 8933
Met Thr Cys Gly Ser Tyr Cys Gly Gly Arg Ala Phe Ser Cys Ile Ser 
1               5                   10                  15      


Ala Cys Gly Pro Arg Pro Gly Arg Cys Cys Ile Thr Ala Ala Pro Tyr 
            20                  25                  30          


Arg Gly Ile Ser Cys Tyr Arg Gly Leu Thr Gly Gly Phe Gly Ser His 
        35                  40                  45              


Ser Val Cys Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe Gly 
    50                  55                  60                  


Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr Thr 
65                  70                  75                  80  


Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp 
                85                  90                  95      


Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys Ser 
            100                 105                 110         


Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu Glu 
        115                 120                 125             


Gln Gln Asn Lys Leu Leu Glu Thr Lys Leu Gln Phe Tyr Gln Asn Arg 
    130                 135                 140                 


Glu Cys Cys Gln Ser Asn Leu Glu Pro Leu Phe Glu Gly Tyr Ile Glu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg Leu 
                165                 170                 175     


Ala Ser Glu Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys Lys 
            180                 185                 190         


Lys Tyr Glu Glu Glu Val Ser Leu Arg Ala Thr Ala Glu Asn Glu Phe 
        195                 200                 205             


Val Ala Leu Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp 
    210                 215                 220                 


Leu Glu Ala Asn Val Glu Ala Leu Ile Gln Glu Ile Asp Phe Leu Arg 
225                 230                 235                 240 


Arg Leu Tyr Glu Glu Glu Ile Arg Val Leu Gln Ser His Ile Ser Asp 
                245                 250                 255     


Thr Ser Val Val Val Lys Leu Asp Asn Ser Arg Asp Leu Asn Met Asp 
            260                 265                 270         


Cys Ile Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Val Thr Arg 
        275                 280                 285             


Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met 
    290                 295                 300                 


Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu 
305                 310                 315                 320 


Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Val 
                325                 330                 335     


Glu Asn Ala Lys Cys Gln Asn Ser Lys Leu Glu Ala Ala Val Ala Gln 
            340                 345                 350         


Ser Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu 
        355                 360                 365             


Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys 
    370                 375                 380                 


Leu Ile Arg Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp 
385                 390                 395                 400 


Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu Gln Arg 
                405                 410                 415     


Leu Cys Glu Gly Val Gly Ser Val Asn Val Cys Val Ser Ser Ser Arg 
            420                 425                 430         


Gly Gly Val Val Cys Gly Asp Leu Cys Ala Ser Thr Thr Ala Pro Val 
        435                 440                 445             


Val Ser Thr Arg Val Ser Ser Val Pro Ser Asn Ser Asn Val Val Val 
    450                 455                 460                 


Gly Thr Thr Asn Ala Cys Ala Pro Ser Ala Arg Val Gly Val Cys Gly 
465                 470                 475                 480 


Gly Ser Cys Lys Arg Cys 
                485     


<210> 8934
<211> 336
<212> PRT
<213> Homo sapiens

<400> 8934
Met Cys Thr Met His Lys Asp Glu Lys Ala Lys Arg Glu Val Ser Ser 
1               5                   10                  15      


Trp Thr Val Glu Gly Asp Ile Asn Thr Asp Pro Trp Ala Gly Tyr Arg 
            20                  25                  30          


Tyr Thr Gly Lys Leu Arg Pro His Tyr Pro Leu Met Pro Thr Arg Pro 
        35                  40                  45              


Val Pro Ser Tyr Ile Gln Arg Pro Asp Tyr Ala Asp His Pro Leu Gly 
    50                  55                  60                  


Met Ser Glu Ser Glu Gln Ala Leu Lys Gly Thr Ser Gln Ile Lys Leu 
65                  70                  75                  80  


Leu Ser Ser Glu Asp Ile Glu Gly Met Arg Leu Val Cys Arg Leu Ala 
                85                  90                  95      


Arg Glu Val Leu Asp Val Ala Ala Gly Met Ile Lys Pro Gly Val Thr 
            100                 105                 110         


Thr Glu Glu Ile Asp His Ala Val His Leu Ala Cys Ile Ala Arg Asn 
        115                 120                 125             


Cys Tyr Pro Ser Pro Leu Asn Tyr Tyr Asn Phe Pro Lys Ser Cys Cys 
    130                 135                 140                 


Thr Ser Val Asn Glu Val Ile Cys His Gly Ile Pro Asp Arg Arg Pro 
145                 150                 155                 160 


Leu Gln Glu Gly Asp Ile Val Asn Val Asp Ile Thr Leu Tyr Arg Asn 
                165                 170                 175     


Gly Tyr His Gly Asp Leu Asn Glu Thr Phe Phe Val Gly Glu Val Asp 
            180                 185                 190         


Asp Gly Ala Arg Lys Leu Val Gln Thr Thr Tyr Glu Cys Leu Met Gln 
        195                 200                 205             


Ala Ile Asp Ala Val Lys Pro Gly Val Arg Tyr Arg Glu Leu Gly Asn 
    210                 215                 220                 


Ile Ile Gln Lys His Ala Gln Ala Asn Gly Phe Ser Val Val Arg Ser 
225                 230                 235                 240 


Tyr Cys Gly His Gly Ile His Lys Leu Phe His Thr Ala Pro Asn Val 
                245                 250                 255     


Pro His Tyr Ala Lys Asn Lys Ala Val Gly Val Met Lys Ser Gly His 
            260                 265                 270         


Val Phe Thr Ile Glu Pro Met Ile Cys Glu Gly Gly Trp Gln Asp Glu 
        275                 280                 285             


Thr Trp Pro Asp Gly Trp Thr Ala Val Thr Arg Asp Gly Lys Arg Ser 
    290                 295                 300                 


Ala Gln Phe Glu His Thr Leu Leu Val Thr Asp Thr Gly Cys Glu Ile 
305                 310                 315                 320 


Leu Thr Arg Arg Leu Asp Ser Ala Arg Pro His Phe Met Ser Gln Phe 
                325                 330                 335     


<210> 8935
<211> 1033
<212> PRT
<213> Homo sapiens

<400> 8935
Met Ala Gly Met Ile Asp Arg Phe Ser Pro Ala Asn Thr Gly Ile Arg 
1               5                   10                  15      


Ser Trp Asp Val Asp Pro Gly Val Cys Asn Leu Asp Glu Gln Leu Lys 
            20                  25                  30          


Val Phe Val Ser Arg His Ser Ala Thr Phe Ser Ser Ile Val Lys Gly 
        35                  40                  45              


Gln Arg Ser Leu His His Arg Gly Asp Asn Leu Glu Thr Leu Val Leu 
    50                  55                  60                  


Leu Asn Pro Ser Asp Lys Ser Leu Tyr Asp Glu Leu Arg Asn Leu Leu 
65                  70                  75                  80  


Leu Asp Pro Ala Ser His Lys Leu Leu Val Leu Ala Gly Pro Cys Leu 
                85                  90                  95      


Glu Glu Thr Gly Glu Leu Leu Leu Gln Thr Gly Gly Phe Ser Pro His 
            100                 105                 110         


His Phe Leu Gln Val Leu Lys Asp Arg Glu Ile Arg Asp Ile Leu Ala 
        115                 120                 125             


Thr Thr Pro Pro Pro Val Gln Pro Pro Ile Leu Thr Ile Thr Cys Pro 
    130                 135                 140                 


Thr Phe Gly Asp Trp Ala Gln Leu Ala Pro Ala Val Pro Gly Leu Gln 
145                 150                 155                 160 


Gly Ala Leu Arg Leu Gln Leu Arg Leu Asn Pro Pro Ala Gln Leu Pro 
                165                 170                 175     


Asn Ser Glu Gly Leu Cys Glu Phe Leu Glu Tyr Val Ala Glu Ser Leu 
            180                 185                 190         


Glu Pro Pro Ser Pro Phe Glu Leu Leu Glu Pro Pro Thr Ser Gly Gly 
        195                 200                 205             


Phe Leu Arg Leu Gly Arg Pro Cys Cys Tyr Ile Phe Pro Gly Gly Leu 
    210                 215                 220                 


Gly Asp Ala Ala Phe Phe Ala Val Asn Gly Phe Thr Val Leu Val Asn 
225                 230                 235                 240 


Gly Gly Ser Asn Pro Lys Ser Ser Phe Trp Lys Leu Val Arg His Leu 
                245                 250                 255     


Asp Arg Val Asp Ala Val Leu Val Thr His Pro Gly Ala Asp Ser Leu 
            260                 265                 270         


Pro Gly Leu Asn Ser Leu Leu Arg Arg Lys Leu Ala Glu Arg Ser Glu 
        275                 280                 285             


Val Ala Ala Gly Gly Gly Ser Trp Asp Asp Arg Leu Arg Arg Leu Ile 
    290                 295                 300                 


Ser Pro Asn Leu Gly Val Val Phe Phe Asn Ala Cys Glu Ala Ala Ser 
305                 310                 315                 320 


Arg Leu Ala Arg Gly Glu Asp Glu Ala Glu Leu Ala Leu Ser Leu Leu 
                325                 330                 335     


Ala Gln Leu Gly Ile Thr Pro Leu Pro Leu Ser Arg Gly Pro Val Pro 
            340                 345                 350         


Ala Lys Pro Thr Val Leu Phe Glu Lys Met Gly Val Gly Arg Leu Asp 
        355                 360                 365             


Met Tyr Val Leu His Pro Pro Ser Ala Gly Ala Glu Arg Thr Leu Ala 
    370                 375                 380                 


Ser Val Cys Ala Leu Leu Val Trp His Pro Ala Gly Pro Gly Glu Lys 
385                 390                 395                 400 


Val Val Arg Val Leu Phe Pro Gly Cys Thr Pro Pro Ala Cys Leu Leu 
                405                 410                 415     


Asp Gly Leu Val Arg Leu Gln His Leu Arg Phe Leu Arg Glu Pro Val 
            420                 425                 430         


Val Thr Pro Gln Asp Leu Glu Gly Pro Gly Arg Ala Glu Ser Lys Glu 
        435                 440                 445             


Ser Val Gly Ser Arg Asp Ser Ser Lys Arg Glu Gly Leu Leu Ala Thr 
    450                 455                 460                 


His Pro Arg Pro Gly Gln Glu Arg Pro Gly Val Ala Arg Lys Glu Pro 
465                 470                 475                 480 


Ala Arg Ala Glu Ala Pro Arg Lys Thr Glu Lys Glu Ala Lys Thr Pro 
                485                 490                 495     


Arg Glu Leu Lys Lys Asp Pro Lys Pro Ser Val Ser Arg Thr Gln Pro 
            500                 505                 510         


Arg Glu Val Arg Arg Ala Ala Ser Ser Val Pro Asn Leu Lys Lys Thr 
        515                 520                 525             


Asn Ala Gln Ala Ala Pro Lys Pro Arg Lys Ala Pro Ser Thr Ser His 
    530                 535                 540                 


Ser Gly Phe Pro Pro Val Ala Asn Gly Pro Arg Ser Pro Pro Ser Leu 
545                 550                 555                 560 


Arg Cys Gly Glu Ala Ser Pro Pro Ser Ala Ala Cys Gly Ser Pro Ala 
                565                 570                 575     


Ser Gln Leu Val Ala Thr Pro Ser Leu Glu Leu Gly Pro Ile Pro Ala 
            580                 585                 590         


Gly Glu Glu Lys Ala Leu Glu Leu Pro Leu Ala Ala Ser Ser Ile Pro 
        595                 600                 605             


Arg Pro Arg Thr Pro Ser Pro Glu Ser His Arg Ser Pro Ala Glu Gly 
    610                 615                 620                 


Ser Glu Arg Leu Ser Leu Ser Pro Leu Arg Gly Gly Glu Ala Gly Pro 
625                 630                 635                 640 


Asp Ala Ser Pro Thr Val Thr Thr Pro Thr Val Thr Thr Pro Ser Leu 
                645                 650                 655     


Pro Ala Glu Val Gly Ser Pro His Ser Thr Glu Val Asp Glu Ser Leu 
            660                 665                 670         


Ser Val Ser Phe Glu Gln Val Leu Pro Pro Ser Ala Pro Thr Ser Glu 
        675                 680                 685             


Ala Gly Leu Ser Leu Pro Leu Arg Gly Pro Arg Ala Arg Arg Ser Ala 
    690                 695                 700                 


Ser Pro His Asp Val Asp Leu Cys Leu Val Ser Pro Cys Glu Phe Glu 
705                 710                 715                 720 


His Arg Lys Ala Val Pro Met Ala Pro Ala Pro Ala Ser Pro Gly Ser 
                725                 730                 735     


Ser Asn Asp Ser Ser Ala Arg Ser Gln Glu Arg Ala Gly Gly Leu Gly 
            740                 745                 750         


Ala Glu Glu Thr Pro Pro Thr Ser Val Ser Glu Ser Leu Pro Thr Leu 
        755                 760                 765             


Ser Asp Ser Asp Pro Val Pro Leu Ala Pro Gly Ala Ala Asp Ser Asp 
    770                 775                 780                 


Glu Asp Thr Glu Gly Phe Gly Val Pro Arg His Asp Pro Leu Pro Asp 
785                 790                 795                 800 


Pro Leu Lys Val Pro Pro Pro Leu Pro Asp Pro Ser Ser Ile Cys Met 
                805                 810                 815     


Val Asp Pro Glu Met Leu Pro Pro Lys Thr Ala Arg Gln Thr Glu Asn 
            820                 825                 830         


Val Ser Arg Thr Arg Lys Pro Leu Ala Arg Pro Asn Ser Arg Ala Ala 
        835                 840                 845             


Ala Pro Lys Ala Thr Pro Val Ala Ala Ala Lys Thr Lys Gly Leu Ala 
    850                 855                 860                 


Gly Gly Asp Arg Ala Ser Arg Pro Leu Ser Ala Arg Ser Glu Pro Ser 
865                 870                 875                 880 


Glu Lys Gly Gly Arg Ala Pro Leu Ser Arg Lys Ser Ser Thr Pro Lys 
                885                 890                 895     


Thr Ala Thr Arg Gly Pro Ser Gly Ser Ala Ser Ser Arg Pro Gly Val 
            900                 905                 910         


Ser Ala Thr Pro Pro Lys Ser Pro Val Tyr Leu Asp Leu Ala Tyr Leu 
        915                 920                 925             


Pro Ser Gly Ser Ser Ala His Leu Val Asp Glu Glu Phe Phe Gln Arg 
    930                 935                 940                 


Val Arg Ala Leu Cys Tyr Val Ile Ser Gly Gln Asp Gln Arg Lys Glu 
945                 950                 955                 960 


Glu Gly Met Arg Ala Val Leu Asp Ala Leu Leu Ala Ser Lys Gln His 
                965                 970                 975     


Trp Asp Arg Asp Leu Gln Val Thr Leu Ile Pro Thr Phe Asp Ser Val 
            980                 985                 990         


Ala Met His Thr Trp Tyr Ala Glu  Thr His Ala Arg His  Gln Ala Leu 
        995                 1000                 1005             


Gly Ile  Thr Val Leu Gly Ser  Asn Ser Met Val Ser  Met Gln Asp 
    1010                 1015                 1020             


Asp Ala  Phe Pro Ala Cys Lys  Val Glu Phe 
    1025                 1030             


<210> 8936
<211> 740
<212> PRT
<213> Homo sapiens

<400> 8936
Met Arg Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln 
1               5                   10                  15      


Leu Arg Pro Ala Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr 
            20                  25                  30          


His Leu Leu Glu Asp Tyr Glu Met Ala Ala Lys Ile Leu Glu Glu Phe 
        35                  40                  45              


Arg Lys Thr Gln Gln Thr Ser Pro Asp Lys Val Asp Tyr Glu Tyr Ser 
    50                  55                  60                  


Glu Leu Leu Leu Tyr Gln Asn Gln Val Leu Arg Glu Ala Gly Leu Tyr 
65                  70                  75                  80  


Arg Glu Ala Leu Glu His Leu Cys Thr Tyr Glu Lys Gln Ile Cys Asp 
                85                  90                  95      


Lys Leu Ala Val Glu Glu Thr Lys Gly Glu Leu Leu Leu Gln Leu Cys 
            100                 105                 110         


Arg Leu Glu Asp Ala Ala Asp Val Tyr Arg Gly Leu Gln Glu Arg Asn 
        115                 120                 125             


Pro Glu Asn Trp Ala Tyr Tyr Lys Gly Leu Glu Lys Ala Leu Lys Pro 
    130                 135                 140                 


Ala Asn Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys 
145                 150                 155                 160 


Tyr Pro Arg Gly Leu Val Pro Arg Arg Leu Pro Leu Asn Phe Leu Ser 
                165                 170                 175     


Gly Glu Lys Phe Lys Glu Cys Leu Asp Lys Phe Leu Arg Met Asn Phe 
            180                 185                 190         


Ser Lys Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Lys 
        195                 200                 205             


Asp Lys Glu Lys Val Ala Ile Ile Glu Glu Leu Val Val Gly Tyr Glu 
    210                 215                 220                 


Thr Ser Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys 
225                 230                 235                 240 


Glu Glu Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln 
                245                 250                 255     


His Tyr Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn 
            260                 265                 270         


Thr Ala Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys 
        275                 280                 285             


Ala Lys Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp 
    290                 295                 300                 


Met Asp Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser 
305                 310                 315                 320 


Lys Cys Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu 
                325                 330                 335     


Glu Met Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn 
            340                 345                 350         


Leu Asn Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala 
        355                 360                 365             


Tyr Lys Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu 
    370                 375                 380                 


Ile Glu Arg His Phe Ile Glu Ile Thr Asp Asp Gln Phe Asp Phe His 
385                 390                 395                 400 


Thr Tyr Cys Met Arg Lys Ile Thr Leu Arg Ser Tyr Val Asp Leu Leu 
                405                 410                 415     


Lys Leu Glu Asp Val Leu Arg Gln His Pro Phe Tyr Phe Lys Ala Ala 
            420                 425                 430         


Arg Ile Ala Ile Glu Ile Tyr Leu Lys Leu His Asp Asn Pro Leu Thr 
        435                 440                 445             


Asp Glu Asn Lys Glu His Glu Ala Asp Thr Ala Asn Met Ser Asp Lys 
    450                 455                 460                 


Glu Leu Lys Lys Leu Arg Asn Lys Gln Arg Arg Ala Gln Lys Lys Ala 
465                 470                 475                 480 


Gln Ile Glu Glu Glu Lys Lys Asn Ala Glu Lys Glu Lys Gln Gln Arg 
                485                 490                 495     


Asn Gln Lys Lys Lys Lys Asp Asp Asp Asp Glu Glu Ile Gly Gly Pro 
            500                 505                 510         


Lys Glu Glu Leu Ile Pro Glu Lys Leu Ala Lys Val Glu Thr Pro Leu 
        515                 520                 525             


Glu Glu Ala Ile Lys Phe Leu Thr Pro Leu Lys Asn Leu Val Lys Asn 
    530                 535                 540                 


Lys Ile Glu Thr His Leu Phe Ala Phe Glu Ile Tyr Phe Arg Lys Glu 
545                 550                 555                 560 


Lys Phe Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asp 
                565                 570                 575     


Ser Ser His Pro Trp Leu His Glu Cys Met Ile Arg Leu Phe Asn Thr 
            580                 585                 590         


Ala Val Cys Glu Ser Lys Asp Leu Ser Asp Thr Val Arg Thr Val Leu 
        595                 600                 605             


Lys Gln Glu Met Asn Arg Leu Phe Gly Ala Thr Asn Pro Lys Asn Phe 
    610                 615                 620                 


Asn Glu Thr Phe Leu Lys Arg Asn Ser Asp Ser Leu Pro His Arg Leu 
625                 630                 635                 640 


Ser Ala Ala Lys Met Val Tyr Tyr Leu Asp Pro Ser Ser Gln Lys Arg 
                645                 650                 655     


Ala Ile Glu Leu Ala Thr Thr Leu Asp Glu Ser Leu Thr Asn Arg Asn 
            660                 665                 670         


Leu Gln Thr Cys Met Glu Val Leu Glu Ala Leu Tyr Asp Gly Ser Leu 
        675                 680                 685             


Gly Asp Cys Lys Glu Ala Ala Glu Ile Tyr Arg Ala Asn Cys His Lys 
    690                 695                 700                 


Leu Phe Pro Tyr Ala Leu Ala Phe Met Pro Pro Gly Tyr Glu Glu Asp 
705                 710                 715                 720 


Met Lys Ile Thr Val Asn Gly Asp Ser Ser Ala Glu Ala Glu Glu Leu 
                725                 730                 735     


Ala Asn Glu Ile 
            740 


<210> 8937
<211> 60
<212> PRT
<213> Homo sapiens

<400> 8937
Met Ser Cys Thr Ile Glu Lys Ala Leu Ala Asp Ala Lys Ala Leu Val 
1               5                   10                  15      


Glu Arg Leu Arg Asp His Asp Asp Ala Ala Glu Ser Leu Ile Glu Gln 
            20                  25                  30          


Thr Thr Ala Leu Asn Lys Arg Val Glu Ala Met Lys Gln Tyr Gln Glu 
        35                  40                  45              


Glu Ile Gln Glu Leu Asn Glu Val Ala Arg His Arg 
    50                  55                  60  


<210> 8938
<211> 472
<212> PRT
<213> Homo sapiens

<400> 8938
Met Gly Lys Glu Gln Glu Leu Leu Glu Ala Ala Arg Thr Gly His Leu 
1               5                   10                  15      


Pro Ala Val Glu Lys Leu Leu Ser Gly Lys Arg Leu Ser Ser Gly Phe 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Leu Gly Ser Ser Ser His Pro Leu Ser Ser Leu 
    50                  55                  60                  


Leu Ser Met Trp Arg Gly Pro Asn Val Asn Cys Val Asp Ser Thr Gly 
65                  70                  75                  80  


Tyr Thr Pro Leu His His Ala Ala Leu Asn Gly His Lys Asp Val Val 
                85                  90                  95      


Glu Val Leu Leu Arg Asn Asp Ala Leu Thr Asn Val Ala Asp Ser Lys 
            100                 105                 110         


Gly Cys Tyr Pro Leu His Leu Ala Ala Trp Lys Gly Asp Ala Gln Ile 
        115                 120                 125             


Val Arg Leu Leu Ile His Gln Gly Pro Ser His Thr Arg Val Asn Glu 
    130                 135                 140                 


Gln Asn Asn Asp Asn Glu Thr Ala Leu His Cys Ala Ala Gln Tyr Gly 
145                 150                 155                 160 


His Thr Glu Val Val Lys Val Leu Leu Glu Glu Leu Thr Asp Pro Thr 
                165                 170                 175     


Met Arg Asn Asn Lys Phe Glu Thr Pro Leu Asp Leu Ala Ala Leu Tyr 
            180                 185                 190         


Gly Arg Leu Glu Val Val Lys Met Leu Leu Asn Ala His Pro Asn Leu 
        195                 200                 205             


Leu Ser Cys Asn Thr Lys Lys His Thr Pro Leu His Leu Ala Ala Arg 
    210                 215                 220                 


Asn Gly His Lys Ala Val Val Gln Val Leu Leu Asp Ala Gly Met Asp 
225                 230                 235                 240 


Ser Asn Tyr Gln Thr Glu Met Gly Ser Ala Leu His Glu Ala Ala Leu 
                245                 250                 255     


Phe Gly Lys Thr Asp Val Val Gln Ile Leu Leu Ala Ala Gly Thr Asp 
            260                 265                 270         


Val Asn Ile Lys Asp Asn His Gly Leu Thr Ala Leu Asp Thr Val Arg 
        275                 280                 285             


Glu Leu Pro Ser Gln Lys Ser Gln Gln Ile Ala Ala Leu Ile Glu Asp 
    290                 295                 300                 


His Met Thr Gly Lys Arg Ser Thr Lys Glu Val Asp Lys Thr Pro Pro 
305                 310                 315                 320 


Pro Gln Pro Pro Leu Ile Ser Ser Met Asp Ser Ile Ser Gln Lys Ser 
                325                 330                 335     


Gln Gly Asp Val Glu Lys Ala Val Thr Glu Leu Ile Ile Asp Phe Asp 
            340                 345                 350         


Ala Asn Ala Glu Glu Glu Gly Pro Tyr Glu Ala Leu Tyr Asn Ala Ile 
        355                 360                 365             


Ser Cys His Ser Leu Asp Ser Met Ala Ser Gly Arg Ser Ser Asp Gln 
    370                 375                 380                 


Asp Ser Thr Asn Lys Glu Ala Glu Ala Ala Gly Val Lys Pro Ala Gly 
385                 390                 395                 400 


Val Arg Pro Arg Glu Arg Pro Pro Pro Pro Ala Lys Pro Pro Pro Asp 
                405                 410                 415     


Glu Glu Glu Glu Asp His Ile Asp Lys Lys Tyr Phe Pro Leu Thr Ala 
            420                 425                 430         


Ser Glu Val Leu Ser Met Arg Pro Arg Ile His Gly Ser Ala Ala Arg 
        435                 440                 445             


Glu Glu Asp Glu His Pro Tyr Glu Leu Leu Leu Thr Ala Glu Thr Lys 
    450                 455                 460                 


Lys Lys Lys Lys Lys Lys Lys Lys 
465                 470         


<210> 8939
<211> 463
<212> PRT
<213> Homo sapiens

<400> 8939
Met Ser Gly Gly Thr Pro Tyr Ile Gly Ser Lys Ile Ser Leu Ile Ser 
1               5                   10                  15      


Lys Ala Glu Ile Arg Tyr Glu Gly Ile Leu Tyr Thr Ile Asp Thr Glu 
            20                  25                  30          


Asn Ser Thr Val Ala Leu Ala Lys Val Arg Ser Phe Gly Thr Glu Asp 
        35                  40                  45              


Arg Pro Thr Asp Arg Pro Ile Pro Pro Arg Asp Glu Val Phe Glu Tyr 
    50                  55                  60                  


Ile Ile Phe Arg Gly Ser Asp Ile Lys Asp Leu Thr Val Cys Glu Pro 
65                  70                  75                  80  


Pro Lys Pro Gln Cys Ser Leu Pro Gln Asp Pro Ala Ile Val Gln Ser 
                85                  90                  95      


Ser Leu Gly Ser Ser Thr Ser Ser Phe Gln Ser Met Gly Ser Tyr Gly 
            100                 105                 110         


Pro Phe Gly Arg Met Pro Thr Tyr Ser Gln Phe Ser Pro Ser Ser Leu 
        115                 120                 125             


Val Gly Gln Gln Phe Gly Ala Val Gly Val Ala Gly Ser Ser Leu Thr 
    130                 135                 140                 


Ser Phe Gly Thr Glu Thr Ser Asn Ser Gly Thr Leu Pro Gln Ser Ser 
145                 150                 155                 160 


Ala Val Gly Ser Ala Phe Thr Gln Asp Thr Arg Ser Leu Lys Thr Gln 
                165                 170                 175     


Leu Ser Gln Gly Arg Ser Ser Pro Gln Leu Asp Pro Leu Arg Lys Ser 
            180                 185                 190         


Pro Thr Met Glu Gln Ala Val Gln Thr Ala Ser Ala His Leu Pro Ala 
        195                 200                 205             


Pro Ala Ala Val Gly Arg Arg Ser Pro Val Ser Thr Arg Pro Leu Pro 
    210                 215                 220                 


Ser Ala Ser Gln Lys Ala Gly Glu Asn Gln Glu His Arg Arg Ala Glu 
225                 230                 235                 240 


Val His Lys Val Ser Arg Pro Glu Asn Glu Gln Leu Arg Asn Asp Asn 
                245                 250                 255     


Lys Arg Gln Val Ala Pro Gly Ala Pro Ser Ala Pro Arg Arg Gly Arg 
            260                 265                 270         


Gly Gly His Arg Gly Gly Arg Gly Arg Phe Gly Ile Arg Arg Asp Gly 
        275                 280                 285             


Pro Met Lys Phe Glu Lys Asp Phe Asp Phe Glu Ser Ala Asn Ala Gln 
    290                 295                 300                 


Phe Asn Lys Glu Glu Ile Asp Arg Glu Phe His Asn Lys Leu Lys Leu 
305                 310                 315                 320 


Lys Glu Asp Lys Leu Glu Lys Gln Glu Lys Pro Val Asn Gly Glu Asp 
                325                 330                 335     


Lys Gly Asp Ser Gly Val Asp Thr Gln Asn Ser Glu Gly Asn Ala Asp 
            340                 345                 350         


Glu Glu Asp Pro Leu Gly Pro Asn Cys Tyr Tyr Asp Lys Thr Lys Ser 
        355                 360                 365             


Phe Phe Asp Asn Ile Ser Cys Asp Asp Asn Arg Glu Arg Arg Pro Thr 
    370                 375                 380                 


Trp Ala Glu Glu Arg Arg Leu Asn Ala Glu Thr Phe Gly Ile Pro Leu 
385                 390                 395                 400 


Arg Pro Asn Arg Gly Arg Gly Gly Tyr Arg Gly Arg Gly Gly Leu Gly 
                405                 410                 415     


Phe Arg Gly Gly Arg Gly Arg Gly Gly Gly Arg Gly Gly Thr Phe Thr 
            420                 425                 430         


Ala Pro Arg Gly Phe Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Arg 
        435                 440                 445             


Glu Phe Ala Asp Phe Glu Tyr Arg Lys Asp Asn Lys Val Ala Ala 
    450                 455                 460             


<210> 8940
<211> 428
<212> PRT
<213> Homo sapiens

<400> 8940
Met Gly Gly Gly Val Gly Ala Ser Ser Ser Gly Gly Gly Pro Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Pro Gly Ala Gly Thr Ser Phe Pro 
            20                  25                  30          


Pro Pro Gly Val Lys Leu Gly Arg Asp Ser Gly Lys Val Thr Thr Val 
        35                  40                  45              


Val Ala Thr Leu Gly Gln Gly Pro Glu Arg Ser Gln Glu Val Ala Tyr 
    50                  55                  60                  


Thr Asp Ile Lys Val Ile Gly Asn Gly Ser Phe Gly Val Val Tyr Gln 
65                  70                  75                  80  


Ala Arg Leu Ala Glu Thr Arg Glu Leu Val Ala Ile Lys Lys Val Leu 
                85                  90                  95      


Gln Asp Lys Arg Phe Lys Asn Arg Glu Leu Gln Ile Met Arg Lys Leu 
            100                 105                 110         


Asp His Cys Asn Ile Val Arg Leu Arg Tyr Phe Phe Tyr Ser Ser Gly 
        115                 120                 125             


Glu Lys Lys Asp Glu Leu Tyr Leu Asn Leu Val Leu Glu Tyr Val Pro 
    130                 135                 140                 


Glu Thr Val Tyr Arg Val Ala Arg His Phe Thr Lys Ala Lys Leu Thr 
145                 150                 155                 160 


Ile Pro Ile Leu Tyr Val Lys Val Tyr Met Tyr Gln Leu Phe Arg Ser 
                165                 170                 175     


Leu Ala Tyr Ile His Ser Gln Gly Val Cys His Arg Asp Ile Lys Pro 
            180                 185                 190         


Gln Asn Leu Leu Val Asp Pro Asp Thr Ala Val Leu Lys Leu Cys Asp 
        195                 200                 205             


Phe Gly Ser Ala Lys Gln Leu Val Arg Gly Glu Pro Asn Val Ser Tyr 
    210                 215                 220                 


Ile Cys Ser Arg Tyr Tyr Arg Ala Pro Glu Leu Ile Phe Gly Ala Thr 
225                 230                 235                 240 


Asp Tyr Thr Ser Ser Ile Asp Val Trp Ser Ala Gly Cys Val Leu Ala 
                245                 250                 255     


Glu Leu Leu Leu Gly Gln Pro Ile Phe Pro Gly Asp Ser Gly Val Asp 
            260                 265                 270         


Gln Leu Val Glu Ile Ile Lys Val Leu Gly Thr Pro Thr Arg Glu Gln 
        275                 280                 285             


Ile Arg Glu Met Asn Pro Asn Tyr Thr Glu Phe Lys Phe Pro Gln Ile 
    290                 295                 300                 


Lys Ala His Pro Trp Thr Lys Val Phe Lys Ser Arg Thr Pro Pro Glu 
305                 310                 315                 320 


Ala Ile Ala Leu Cys Ser Ser Leu Leu Glu Tyr Thr Pro Ser Ser Arg 
                325                 330                 335     


Leu Ser Pro Leu Glu Ala Cys Ala His Ser Phe Phe Asp Glu Leu Arg 
            340                 345                 350         


Cys Leu Gly Thr Gln Leu Pro Asn Asn Arg Pro Leu Pro Pro Leu Phe 
        355                 360                 365             


Asn Phe Ser Ala Gly Glu Leu Ser Ile Gln Pro Ser Leu Asn Ala Ile 
    370                 375                 380                 


Leu Ile Pro Pro His Leu Arg Ser Pro Ala Gly Thr Thr Thr Leu Thr 
385                 390                 395                 400 


Pro Ser Ser Gln Ala Leu Thr Glu Thr Pro Thr Ser Ser Asp Trp Gln 
                405                 410                 415     


Ser Thr Asp Ala Thr Pro Thr Leu Thr Asn Ser Ser 
            420                 425             


<210> 8941
<211> 218
<212> PRT
<213> Homo sapiens

<400> 8941
Met Asp Ala Glu His Pro Glu Leu Arg Ser Tyr Ala Gln Ser Gln Gly 
1               5                   10                  15      


Trp Trp Thr Gly Glu Gly Glu Phe Asn Phe Ser Glu Val Phe Ser Pro 
            20                  25                  30          


Val Glu Asp His Leu Asp Cys Gly Ala Gly Lys Asp Ser Leu Glu Lys 
        35                  40                  45              


Gln Glu Glu Ser Ile Thr Val Gln Thr Met Met Asn Thr Leu Arg Asp 
    50                  55                  60                  


Lys Ala Ser Gly Val Cys Ile Asp Ser Glu Phe Phe Leu Thr Thr Ala 
65                  70                  75                  80  


Ser Gly Val Ser Val Leu Pro Gln Asn Arg Ser Ser Pro Cys Ile His 
                85                  90                  95      


Tyr Phe Thr Gly Thr Pro Asp Pro Ser Arg Ser Ile Phe Lys Pro Phe 
            100                 105                 110         


Ile Phe Val Asp Asp Val Lys Leu Val Pro Lys Thr Gln Ser Pro Cys 
        115                 120                 125             


Phe Gly Asp Asp Asp Pro Ala Lys Lys Glu Pro Arg Phe Gln Glu Lys 
    130                 135                 140                 


Pro Asp Arg Arg His Glu Leu Tyr Lys Ala His Glu Trp Ala Arg Ala 
145                 150                 155                 160 


Ile Ile Glu Ser Asp Gln Glu Gln Gly Arg Lys Leu Arg Ser Thr Met 
                165                 170                 175     


Leu Glu Leu Glu Lys Gln Gly Leu Glu Ala Met Glu Glu Ile Leu Thr 
            180                 185                 190         


Ser Ser Glu Pro Leu Asp Pro Ala Glu Val Gly Asp Leu Phe Tyr Asp 
        195                 200                 205             


Cys Val Asp Thr Glu Ile Lys Phe Phe Lys 
    210                 215             


<210> 8942
<211> 190
<212> PRT
<213> Homo sapiens

<400> 8942
Met Ala Leu Leu Ala Glu His Leu Leu Lys Pro Leu Pro Ala Asp Lys 
1               5                   10                  15      


Gln Ile Glu Thr Gly Pro Phe Leu Glu Ala Val Ser His Leu Pro Pro 
            20                  25                  30          


Phe Phe Asp Cys Leu Gly Ser Pro Val Phe Thr Pro Ile Lys Ala Asp 
        35                  40                  45              


Ile Ser Gly Asn Ile Thr Lys Ile Lys Ala Val Tyr Asp Thr Asn Pro 
    50                  55                  60                  


Ala Lys Phe Arg Thr Leu Gln Asn Ile Leu Glu Val Glu Lys Glu Ile 
65                  70                  75                  80  


Gly Leu Arg Phe Ile Gln Val Phe Leu Gln Ser Ile Cys Asp Gly Glu 
                85                  90                  95      


Arg Asp Glu Asn His Pro Asn Leu Ile Arg Val Asn Ala Thr Lys Ala 
            100                 105                 110         


Tyr Glu Met Ala Leu Lys Lys Tyr His Gly Trp Ile Val Gln Lys Ile 
        115                 120                 125             


Phe Gln Ala Ala Leu Tyr Ala Ala Pro Tyr Lys Ser Asp Phe Leu Lys 
    130                 135                 140                 


Ala Leu Ser Lys Gly Gln Asn Val Thr Glu Glu Glu Cys Leu Glu Lys 
145                 150                 155                 160 


Ile Arg Leu Phe Leu Val Asn Tyr Thr Ala Thr Ile Asp Val Ile Tyr 
                165                 170                 175     


Glu Met Tyr Thr Gln Met Asn Ala Glu Leu Asn Tyr Lys Val 
            180                 185                 190 


<210> 8943
<211> 253
<212> PRT
<213> Homo sapiens

<400> 8943
Met Ser Ile Cys Ser Ser Leu Ala Arg Lys Phe Pro Lys Leu Thr Ile 
1               5                   10                  15      


Ile Gly Glu Glu Asp Leu Pro Ser Glu Glu Val Asp Gln Glu Leu Ile 
            20                  25                  30          


Glu Asp Ser Gln Trp Glu Glu Ile Leu Lys Gln Pro Cys Pro Ser Gln 
        35                  40                  45              


Tyr Ser Ala Ile Lys Glu Glu Asp Leu Val Val Trp Val Asp Pro Leu 
    50                  55                  60                  


Asp Gly Thr Lys Glu Tyr Thr Glu Gly Leu Leu Asp Asn Val Thr Val 
65                  70                  75                  80  


Leu Ile Gly Ile Ala Tyr Glu Gly Lys Ala Ile Ala Gly Val Ile Asn 
                85                  90                  95      


Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly Pro Asp Ala Val Leu Gly Arg 
            100                 105                 110         


Thr Ile Trp Gly Val Leu Gly Leu Gly Ala Phe Gly Phe Gln Leu Lys 
        115                 120                 125             


Glu Val Pro Ala Gly Lys His Ile Ile Thr Thr Thr Arg Ser His Ser 
    130                 135                 140                 


Asn Lys Leu Val Thr Asp Cys Val Ala Ala Met Asn Pro Asp Ala Val 
145                 150                 155                 160 


Leu Arg Val Gly Gly Ala Gly Asn Lys Ile Ile Gln Leu Ile Glu Gly 
                165                 170                 175     


Lys Ala Ser Ala Tyr Val Phe Ala Ser Pro Gly Cys Lys Lys Trp Asp 
            180                 185                 190         


Thr Cys Ala Pro Glu Val Ile Leu His Ala Val Gly Gly Lys Leu Thr 
        195                 200                 205             


Asp Ile His Gly Asn Val Leu Gln Tyr His Lys Asp Val Lys His Met 
    210                 215                 220                 


Asn Ser Ala Gly Val Leu Ala Thr Leu Arg Asn Tyr Asp Tyr Tyr Ala 
225                 230                 235                 240 


Ser Arg Val Pro Glu Ser Ile Lys Asn Ala Leu Val Pro 
                245                 250             


<210> 8944
<211> 529
<212> PRT
<213> Homo sapiens

<400> 8944
Met Gly Ala Tyr Leu Ser Gln Pro Asn Thr Val Lys Cys Ser Gly Asp 
1               5                   10                  15      


Gly Val Gly Val Ser Met Glu Asp Ala His Asn Cys Ile Pro Glu Leu 
            20                  25                  30          


Asp Ser Glu Thr Ala Met Phe Ser Val Tyr Asp Gly His Gly Gly Glu 
        35                  40                  45              


Glu Val Ala Leu Tyr Cys Ala Lys Tyr Leu Pro Asp Ile Ile Lys Asp 
    50                  55                  60                  


Gln Lys Ala Tyr Lys Glu Gly Lys Leu Gln Lys Ala Leu Glu Asp Ala 
65                  70                  75                  80  


Phe Leu Ala Ile Asp Ala Lys Leu Thr Thr Glu Glu Val Ile Lys Glu 
                85                  90                  95      


Leu Ala Gln Ile Ala Gly Arg Pro Thr Glu Asp Glu Asp Glu Lys Glu 
            100                 105                 110         


Lys Val Ala Asp Glu Asp Asp Val Asp Asn Glu Glu Ala Ala Leu Leu 
        115                 120                 125             


His Glu Glu Ala Thr Met Thr Ile Glu Glu Leu Leu Thr Arg Tyr Gly 
    130                 135                 140                 


Gln Asn Cys His Lys Gly Pro Pro His Ser Lys Ser Gly Gly Gly Thr 
145                 150                 155                 160 


Gly Glu Glu Pro Gly Ser Gln Gly Leu Asn Gly Glu Ala Gly Pro Glu 
                165                 170                 175     


Asp Ser Thr Arg Glu Thr Pro Ser Gln Glu Asn Gly Pro Thr Ala Lys 
            180                 185                 190         


Ala Tyr Thr Gly Phe Ser Ser Asn Ser Glu Arg Gly Thr Glu Ala Gly 
        195                 200                 205             


Gln Val Gly Glu Pro Gly Ile Pro Thr Gly Glu Ala Gly Pro Ser Cys 
    210                 215                 220                 


Ser Ser Ala Ser Asp Lys Leu Pro Arg Val Ala Lys Ser Lys Phe Phe 
225                 230                 235                 240 


Glu Asp Ser Glu Asp Glu Ser Asp Glu Ala Glu Glu Glu Glu Glu Asp 
                245                 250                 255     


Ser Glu Glu Cys Ser Glu Glu Glu Asp Gly Tyr Ser Ser Glu Glu Ala 
            260                 265                 270         


Glu Asn Glu Glu Asp Glu Asp Asp Thr Glu Glu Ala Glu Glu Asp Asp 
        275                 280                 285             


Glu Glu Glu Glu Glu Glu Met Met Val Pro Gly Met Glu Gly Lys Glu 
    290                 295                 300                 


Glu Pro Gly Ser Asp Ser Gly Thr Thr Ala Val Val Ala Leu Ile Arg 
305                 310                 315                 320 


Gly Lys Gln Leu Ile Val Ala Asn Ala Gly Asp Ser Arg Cys Val Val 
                325                 330                 335     


Ser Glu Ala Gly Lys Ala Leu Asp Met Ser Tyr Asp His Lys Pro Glu 
            340                 345                 350         


Asp Glu Val Glu Leu Ala Arg Ile Lys Asn Ala Gly Gly Lys Val Thr 
        355                 360                 365             


Met Asp Gly Arg Val Asn Gly Gly Leu Asn Leu Ser Arg Ala Ile Gly 
    370                 375                 380                 


Asp His Phe Tyr Lys Arg Asn Lys Asn Leu Pro Pro Glu Glu Gln Met 
385                 390                 395                 400 


Ile Ser Ala Leu Pro Asp Ile Lys Val Leu Thr Leu Thr Asp Asp His 
                405                 410                 415     


Glu Phe Met Val Ile Ala Cys Asp Gly Ile Trp Asn Val Met Ser Ser 
            420                 425                 430         


Gln Glu Val Val Asp Phe Ile Gln Ser Lys Ile Ser Gln Arg Asp Glu 
        435                 440                 445             


Asn Gly Glu Leu Arg Leu Leu Ser Ser Ile Val Glu Glu Leu Leu Asp 
    450                 455                 460                 


Gln Cys Leu Ala Pro Asp Thr Ser Gly Asp Gly Thr Gly Cys Asp Asn 
465                 470                 475                 480 


Met Thr Cys Ile Ile Ile Cys Phe Lys Pro Arg Asn Thr Ala Glu Leu 
                485                 490                 495     


Gln Pro Glu Ser Gly Lys Arg Lys Leu Glu Glu Val Leu Ser Thr Glu 
            500                 505                 510         


Gly Ala Glu Glu Asn Gly Asn Ser Asp Lys Lys Lys Lys Ala Lys Arg 
        515                 520                 525             


Asp 
    


<210> 8945
<211> 430
<212> PRT
<213> Homo sapiens

<400> 8945
Met Thr Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn Val Gln 
1               5                   10                  15      


Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu Lys Leu 
            20                  25                  30          


Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe Leu Ser 
        35                  40                  45              


Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Thr Pro Ser Asn Met 
    50                  55                  60                  


Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu Gly Asn 
65                  70                  75                  80  


Ile Thr Glu Met Met Thr Thr Val Ser Leu Gln Ile Val Gly Ile Ile 
                85                  90                  95      


Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu Ile Glu 
            100                 105                 110         


Phe Asn Ile Thr Gly Asn Tyr Gly Ser Pro Val His Val Asn His Asn 
        115                 120                 125             


Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala Asp Arg 
    130                 135                 140                 


Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Thr Asp Asn 
145                 150                 155                 160 


Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Met Gly Val Arg Val Met 
                165                 170                 175     


Asp Thr Asn Trp Val Ala Arg Arg Gly Ser Ser Ala Gly Arg Lys Val 
            180                 185                 190         


Ser Cys Ala Pro Pro Ser Met Gln Pro Pro Ala Pro Pro Ala Glu Leu 
        195                 200                 205             


Ala Ala Pro Leu Pro Ser Pro Leu Pro Glu Gln Pro Leu Asp Ser Pro 
    210                 215                 220                 


Ala Ala Pro Ala Leu Ser Pro Ser Gly Leu Gly Leu Gln Pro Gly Pro 
225                 230                 235                 240 


Glu Arg Thr Ser Thr Thr Lys Ser Lys Glu Leu Ser Pro Gly Ser Ala 
                245                 250                 255     


Gln Lys Gly Ser Pro Gly Ser Ser Gln Gly Thr Ala Cys Ala Gly Thr 
            260                 265                 270         


Gln Pro Gly Ala Gln Pro Gly Ala Gln Pro Gly Ala Ser Pro Ser Pro 
        275                 280                 285             


Ser Gln Pro Pro Ala Asp Gln Ser Pro His Thr Leu Arg Lys Val Ser 
    290                 295                 300                 


Lys Lys Leu Ala Pro Ile Pro Pro Lys Val Pro Phe Gly Gln Pro Gly 
305                 310                 315                 320 


Ala Met Ala Asp Gln Ser Ala Gly Gln Pro Ser Pro Val Ser Leu Ser 
                325                 330                 335     


Pro Thr Pro Pro Ser Thr Pro Ser Pro Tyr Gly Leu Ser Tyr Pro Gln 
            340                 345                 350         


Gly Tyr Ser Leu Ala Ser Gly Gln Leu Ser Pro Ala Ala Ala Pro Pro 
        355                 360                 365             


Leu Ala Ser Pro Ser Val Phe Thr Ser Thr Leu Ser Lys Ser Arg Pro 
    370                 375                 380                 


Thr Pro Lys Pro Arg Gln Arg Pro Thr Leu Pro Pro Pro Gln Pro Pro 
385                 390                 395                 400 


Thr Val Asn Leu Ser Ala Ser Ser Pro Gln Ser Thr Glu Ala Pro Met 
                405                 410                 415     


Leu Asp Gly Met Ser Pro Gly Glu Ser Met Ser Thr Ala Val 
            420                 425                 430 


<210> 8946
<211> 281
<212> PRT
<213> Homo sapiens

<400> 8946
Met Pro Gly Pro Arg Arg Leu Arg Ser Pro Gly Gly Ser Gly Cys Ser 
1               5                   10                  15      


Ser Arg Gly Ser Gly Pro Arg Leu Ser Thr Arg Arg Trp Arg Pro Cys 
            20                  25                  30          


Cys Tyr Cys Gly Gly Ser Gly Val Trp Leu Leu Arg Thr Pro Pro Ser 
        35                  40                  45              


Pro Ser Ala Trp Pro Ala Arg Arg Cys Pro Arg His Arg Phe Glu Phe 
    50                  55                  60                  


Cys Glu Pro Ala Phe Val Val Gly Asn Cys Leu Gln Ile Ala Ser Asp 
65                  70                  75                  80  


Ser His Gln Tyr Asp Arg Ile Tyr Cys Gly Ala Gly Val Gln Lys Asp 
                85                  90                  95      


His Glu Asn Tyr Met Lys Ile Leu Leu Lys Val Gly Gly Ile Leu Val 
            100                 105                 110         


Met Pro Ile Glu Asp Gln Leu Thr Gln Ile Met Arg Thr Gly Gln Asn 
        115                 120                 125             


Thr Trp Glu Ser Lys Asn Ile Leu Ala Val Ser Phe Ala Pro Leu Val 
    130                 135                 140                 


Gln Pro Ser Lys Asn Asp Asn Gly Lys Pro Asp Ser Val Gly Leu Pro 
145                 150                 155                 160 


Pro Cys Ala Val Arg Asn Leu Gln Asp Leu Ala Arg Ile Tyr Ile Arg 
                165                 170                 175     


Arg Thr Leu Arg Asn Phe Ile Asn Asp Glu Met Gln Ala Lys Gly Ile 
            180                 185                 190         


Pro Gln Arg Ala Pro Pro Lys Arg Lys Arg Lys Arg Val Lys Gln Arg 
        195                 200                 205             


Ile Asn Thr Tyr Val Phe Val Gly Asn Gln Leu Ile Pro Gln Pro Leu 
    210                 215                 220                 


Asp Ser Glu Glu Asp Glu Lys Met Glu Glu Asp Asn Lys Glu Glu Glu 
225                 230                 235                 240 


Glu Lys Asp His Asn Glu Ala Met Lys Pro Glu Glu Pro Pro Gln Asn 
                245                 250                 255     


Leu Leu Arg Glu Lys Ile Met Lys Leu Pro Leu Pro Glu Ser Leu Lys 
            260                 265                 270         


Ala Tyr Leu Thr Tyr Phe Arg Asp Lys 
        275                 280     


<210> 8947
<211> 416
<212> PRT
<213> Homo sapiens

<400> 8947
Met Ser Pro Ala Met Leu Ser Val Leu Val Lys Met Met Leu Ala Gln 
1               5                   10                  15      


Ala Gln Glu Ser Val Phe Glu Lys Ile Ser Leu Pro Gly Ile Arg Asn 
            20                  25                  30          


Glu Phe Phe Met Leu Val Lys Val Ala Gln Glu Ala Ala Lys Val Gly 
        35                  40                  45              


Glu Val Tyr Gln Gln Leu His Ala Ala Met Ser Gln Ala Pro Val Lys 
    50                  55                  60                  


Glu Asn Ile Pro Tyr Ser Trp Ala Ser Leu Ala Cys Val Lys Ala His 
65                  70                  75                  80  


His Tyr Ala Ala Leu Ala His Tyr Phe Thr Ala Ile Leu Leu Ile Asp 
                85                  90                  95      


His Gln Val Lys Pro Gly Thr Asp Leu Asp His Gln Glu Lys Cys Leu 
            100                 105                 110         


Ser Gln Leu Tyr Asp His Met Pro Glu Gly Leu Thr Pro Leu Ala Thr 
        115                 120                 125             


Leu Lys Asn Asp Gln Gln Arg Arg Gln Leu Gly Lys Ser His Leu Arg 
    130                 135                 140                 


Arg Ala Met Ala His His Glu Glu Ser Val Arg Glu Ala Ser Leu Cys 
145                 150                 155                 160 


Lys Lys Leu Arg Ser Ile Glu Val Leu Gln Lys Val Leu Cys Ala Ala 
                165                 170                 175     


Gln Glu Arg Ser Arg Leu Thr Tyr Ala Gln His Gln Glu Glu Asp Asp 
            180                 185                 190         


Leu Leu Asn Leu Ile Asp Ala Pro Ser Val Val Ala Lys Thr Glu Gln 
        195                 200                 205             


Glu Val Asp Ile Ile Leu Pro Gln Phe Ser Lys Leu Thr Val Thr Asp 
    210                 215                 220                 


Phe Phe Gln Lys Leu Gly Pro Leu Ser Val Phe Ser Ala Asn Lys Arg 
225                 230                 235                 240 


Trp Thr Pro Pro Arg Ser Ile Arg Phe Thr Ala Glu Glu Gly Asp Leu 
                245                 250                 255     


Gly Phe Thr Leu Arg Gly Asn Ala Pro Val Gln Val His Phe Leu Asp 
            260                 265                 270         


Pro Tyr Cys Ser Ala Ser Val Ala Gly Ala Arg Glu Gly Asp Tyr Ile 
        275                 280                 285             


Val Ser Ile Gln Leu Val Asp Cys Lys Trp Leu Thr Leu Ser Glu Val 
    290                 295                 300                 


Met Lys Leu Leu Lys Ser Phe Gly Glu Asp Glu Ile Glu Met Lys Val 
305                 310                 315                 320 


Val Ser Leu Leu Asp Ser Thr Ser Ser Met His Asn Lys Ser Ala Thr 
                325                 330                 335     


Tyr Ser Val Gly Met Gln Lys Thr Tyr Ser Met Ile Cys Leu Ala Ile 
            340                 345                 350         


Asp Asp Asp Asp Lys Thr Asp Lys Thr Lys Lys Ile Ser Lys Lys Leu 
        355                 360                 365             


Ser Phe Leu Ser Trp Gly Thr Asn Lys Asn Arg Gln Lys Ser Ala Ser 
    370                 375                 380                 


Thr Leu Cys Leu Pro Ser Val Gly Ala Ala Arg Pro Gln Val Lys Lys 
385                 390                 395                 400 


Lys Leu Pro Ser Pro Phe Ser Leu Leu Asn Ser Asp Ser Ser Trp Tyr 
                405                 410                 415     


<210> 8948
<211> 2066
<212> PRT
<213> Homo sapiens

<400> 8948
Met Cys Ser Thr Pro Gly Met Pro Ala Pro Gly Ala Ser Leu Ala Leu 
1               5                   10                  15      


Arg Val Ser Phe Val Asp Val His Pro Asp Val Ile Pro Val Gln Leu 
            20                  25                  30          


Trp Gly Leu Val Gly Glu Arg Arg Gly Glu Tyr Leu Arg Leu Ser Arg 
        35                  40                  45              


Glu Ile Gln Glu Ala Ala Ala Thr Arg Gly Gln Trp Ala Leu Gly Ser 
    50                  55                  60                  


Ala Ser Ala Ser Pro Gly Glu Leu Cys Leu Val Gln Val Gly Leu Leu 
65                  70                  75                  80  


Trp His Arg Cys Arg Val Val Ser Arg Gln Ala Gln Glu Ser Arg Val 
                85                  90                  95      


Phe Leu Leu Asp Glu Gly Arg Thr Ile Thr Ala Gly Ala Gly Ser Leu 
            100                 105                 110         


Ala Pro Gly Arg Arg Glu Phe Phe Asn Leu Pro Ser Glu Val Leu Gly 
        115                 120                 125             


Cys Val Leu Ala Gly Leu Val Pro Ala Gly Cys Gly Ala Gly Ser Gly 
    130                 135                 140                 


Glu Pro Pro Gln His Trp Pro Ala Asp Ala Val Asp Phe Leu Ser Asn 
145                 150                 155                 160 


Leu Gln Gly Lys Glu Val His Gly Cys Val Leu Asp Val Leu Leu Leu 
                165                 170                 175     


His Arg Leu Val Leu Leu Glu Val Pro Asp Val Phe Gln Gln Met Arg 
            180                 185                 190         


Glu Leu Gly Leu Ala Arg Arg Val Pro Asp Ser Leu Phe Arg Ser Leu 
        195                 200                 205             


Leu Glu Arg Tyr Leu Thr Ala Ala Thr Ala Ser Val Gly Ser Gly Val 
    210                 215                 220                 


Pro Val Leu Ser Arg Val Pro Leu Lys Gln Lys Gln Pro Gly Leu Asp 
225                 230                 235                 240 


Tyr Phe Tyr Pro Gln Leu Gln Leu Gly Val Thr Glu Ala Val Val Ile 
                245                 250                 255     


Thr Gln Val Cys His Pro His Arg Ile His Cys Gln Leu Arg Ser Val 
            260                 265                 270         


Ser Gln Glu Ile His Arg Leu Ser Glu Ser Met Ala Gln Val Tyr Arg 
        275                 280                 285             


Gly Ser Thr Gly Thr Gly Asp Glu Asn Ser Thr Ser Ala Thr Trp Glu 
    290                 295                 300                 


Glu Arg Glu Glu Ser Pro Asp Lys Pro Gly Ser Pro Cys Ala Ser Cys 
305                 310                 315                 320 


Gly Leu Asp Gly His Trp Tyr Arg Ala Leu Leu Leu Glu Thr Phe Arg 
                325                 330                 335     


Pro Gln Arg Cys Ala Gln Val Leu His Val Asp Tyr Gly Arg Lys Glu 
            340                 345                 350         


Leu Val Ser Cys Ser Ser Leu Arg Tyr Leu Leu Pro Glu Tyr Phe Arg 
        355                 360                 365             


Met Pro Val Val Thr Tyr Pro Cys Ala Leu Tyr Gly Leu Trp Asp Gly 
    370                 375                 380                 


Gly Arg Gly Trp Ser Arg Ser Gln Val Gly Asp Leu Lys Thr Leu Ile 
385                 390                 395                 400 


Leu Gly Lys Ala Val Asn Ala Lys Ile Glu Phe Tyr Cys Ser Phe Glu 
                405                 410                 415     


His Val Tyr Tyr Val Ser Leu Tyr Gly Glu Asp Gly Ile Asn Leu Asn 
            420                 425                 430         


Arg Val Phe Gly Val Gln Ser Cys Cys Leu Ala Asp Arg Val Leu Gln 
        435                 440                 445             


Ser Gln Ala Thr Glu Glu Glu Glu Pro Glu Thr Ser Gln Ser Gln Ser 
    450                 455                 460                 


Pro Ala Glu Glu Val Asp Glu Glu Ile Ser Leu Pro Ala Leu Arg Ser 
465                 470                 475                 480 


Ile Arg Leu Lys Met Asn Ala Phe Tyr Asp Ala Gln Val Glu Phe Val 
                485                 490                 495     


Lys Asn Pro Ser Glu Phe Trp Ile Arg Leu Arg Lys His Asn Val Thr 
            500                 505                 510         


Phe Ser Lys Leu Met Arg Arg Met Cys Gly Phe Tyr Ser Ser Ala Ser 
        515                 520                 525             


Lys Leu Asp Gly Val Val Leu Lys Pro Glu Pro Asp Asp Leu Cys Cys 
    530                 535                 540                 


Val Lys Trp Lys Glu Asn Gly Tyr Tyr Arg Ala Ile Val Thr Lys Leu 
545                 550                 555                 560 


Asp Asp Lys Ser Val Asp Val Phe Leu Val Asp Arg Gly Asn Ser Glu 
                565                 570                 575     


Asn Val Asp Trp Tyr Asp Val Arg Met Leu Leu Pro Gln Phe Arg Gln 
            580                 585                 590         


Leu Pro Ile Leu Ala Val Lys Cys Thr Leu Ala Asp Ile Trp Pro Leu 
        595                 600                 605             


Gly Lys Thr Trp Ser Gln Glu Ala Val Ser Phe Phe Lys Lys Thr Val 
    610                 615                 620                 


Leu His Lys Glu Leu Val Ile His Ile Leu Asp Lys Gln Asp His Gln 
625                 630                 635                 640 


Tyr Val Ile Glu Ile Leu Asp Glu Ser Arg Thr Gly Glu Glu Asn Ile 
                645                 650                 655     


Ser Lys Val Ile Ala Gln Ala Gly Tyr Ala Lys Tyr Gln Glu Phe Glu 
            660                 665                 670         


Thr Lys Glu Asn Ile Leu Val Asn Ala His Ser Pro Gly His Val Ser 
        675                 680                 685             


Asn His Phe Thr Thr Glu Ser Asn Lys Ile Pro Phe Ala Lys Thr Gly 
    690                 695                 700                 


Glu Gly Glu Gln Lys Ala Lys Arg Glu Asn Lys Thr Thr Ser Val Ser 
705                 710                 715                 720 


Lys Ala Leu Ser Asp Thr Thr Val Val Thr Asn Gly Ser Thr Glu Leu 
                725                 730                 735     


Val Val Gln Glu Lys Val Lys Arg Ala Ser Val Tyr Phe Pro Leu Met 
            740                 745                 750         


Gln Asn Cys Leu Glu Ile Lys Pro Gly Ser Ser Ser Lys Gly Glu Leu 
        755                 760                 765             


Glu Val Gly Ser Thr Val Glu Val Arg Val Ser Tyr Val Glu Asn Pro 
    770                 775                 780                 


Gly Tyr Phe Trp Cys Gln Leu Thr Arg Asn Ile Gln Gly Leu Lys Thr 
785                 790                 795                 800 


Leu Met Ser Asp Ile Gln Tyr Tyr Cys Lys Asn Thr Ala Ala Pro His 
                805                 810                 815     


Gln Arg Asn Thr Leu Ala Cys Leu Ala Lys Arg Thr Val Asn Arg Gln 
            820                 825                 830         


Trp Ser Arg Ala Leu Ile Ser Gly Ile Gln Ser Val Glu His Val Asn 
        835                 840                 845             


Val Thr Phe Val Asp Tyr Gly Asp Arg Glu Met Val Ser Val Lys Asn 
    850                 855                 860                 


Ile Tyr Ser Ile Ser Glu Glu Phe Leu Lys Val Lys Ala Gln Ala Phe 
865                 870                 875                 880 


Arg Cys Ser Leu Tyr Asn Leu Ile Gln Pro Val Gly Gln Asn Pro Phe 
                885                 890                 895     


Val Trp Asp Val Lys Ala Ile Gln Ala Phe Asn Glu Phe Ile Asp Asn 
            900                 905                 910         


Ala Trp Gln Lys Asn Leu Glu Leu Lys Cys Thr Ile Phe Ala Leu Ala 
        915                 920                 925             


Ser Ile Asn Glu Glu Leu Phe Asn Ile Val Asp Leu Leu Thr Pro Phe 
    930                 935                 940                 


Gln Ser Ala Cys His Phe Leu Val Glu Lys Arg Leu Ala Arg Pro Val 
945                 950                 955                 960 


Lys Leu Gln Lys Pro Leu Glu Ser Ser Val Gln Leu His Ser Tyr Phe 
                965                 970                 975     


Tyr Ser Thr His Asp Met Lys Ile Gly Ser Glu Glu Leu Val Tyr Ile 
            980                 985                 990         


Thr His Ile Asp Asp Pro Trp Thr  Phe Tyr Cys Gln Leu  Ala Arg Asn 
        995                 1000                 1005             


Ala Asn  Ile Leu Glu Gln Leu  Ser Cys Ser Ile Thr  Gln Leu Ser 
    1010                 1015                 1020             


Lys Val  Leu Leu Asn Leu Lys  Thr Ser Pro Leu Asn  Pro Gly Thr 
    1025                 1030                 1035             


Leu Cys  Leu Ala Lys Tyr Thr  Asp Gly Asn Trp Tyr  Arg Gly Ile 
    1040                 1045                 1050             


Val Ile  Glu Lys Glu Pro Lys  Lys Val Phe Phe Val  Asp Phe Gly 
    1055                 1060                 1065             


Asn Ile  Tyr Val Val Thr Ser  Asp Asp Leu Leu Pro  Ile Pro Ser 
    1070                 1075                 1080             


Asp Ala  Tyr Asp Val Leu Leu  Leu Pro Met Gln Ala  Val Arg Cys 
    1085                 1090                 1095             


Ser Leu  Ser Asp Ile Pro Asp  His Ile Pro Glu Glu  Val Val Val 
    1100                 1105                 1110             


Trp Phe  Gln Glu Thr Ile Leu  Asp Lys Ser Leu Lys  Ala Leu Val 
    1115                 1120                 1125             


Val Ala  Lys Asp Pro Asp Gly  Thr Leu Ile Ile Glu  Leu Tyr Gly 
    1130                 1135                 1140             


Asp Asn  Ile Gln Ile Ser Ala  Ser Ile Asn Lys Lys  Leu Gly Leu 
    1145                 1150                 1155             


Leu Ser  Tyr Lys Asp Arg Ile  Arg Lys Lys Glu Ser  Glu Val Leu 
    1160                 1165                 1170             


Cys Ser  Thr Thr Glu Thr Leu  Glu Glu Lys Asn Glu  Asn Met Lys 
    1175                 1180                 1185             


Leu Pro  Cys Thr Glu Tyr Leu  Ser Lys Ser Val Gly  Tyr Lys Leu 
    1190                 1195                 1200             


Pro Asn  Lys Glu Ile Leu Glu  Glu Ser Tyr Lys Pro  Gln Ile Asn 
    1205                 1210                 1215             


Ser Ser  Tyr Lys Glu Leu Lys  Leu Leu Gln Ser Leu  Thr Lys Thr 
    1220                 1225                 1230             


Asn Leu  Val Thr Gln Tyr Gln  Asp Ser Val Gly Asn  Lys Asn Ser 
    1235                 1240                 1245             


Gln Val  Phe Pro Leu Thr Thr  Glu Lys Lys Glu Glu  Ile Ser Ala 
    1250                 1255                 1260             


Glu Thr  Pro Leu Lys Thr Ala  Arg Val Glu Ala Thr  Leu Ser Glu 
    1265                 1270                 1275             


Arg Lys  Ile Gly Asp Ser Cys  Asp Lys Asp Leu Pro  Leu Lys Phe 
    1280                 1285                 1290             


Cys Glu  Phe Pro Gln Lys Thr  Ile Met Pro Gly Phe  Lys Thr Thr 
    1295                 1300                 1305             


Val Tyr  Val Ser His Ile Asn  Asp Leu Ser Asp Phe  Tyr Val Gln 
    1310                 1315                 1320             


Leu Ile  Glu Asp Glu Ala Glu  Ile Ser His Leu Ser  Glu Arg Leu 
    1325                 1330                 1335             


Asn Ser  Val Lys Thr Arg Pro  Glu Tyr Tyr Val Gly  Pro Pro Leu 
    1340                 1345                 1350             


Gln Arg  Gly Asp Met Ile Cys  Ala Val Phe Pro Glu  Asp Asn Leu 
    1355                 1360                 1365             


Trp Tyr  Arg Ala Val Ile Lys  Glu Gln Gln Pro Asn  Asp Leu Leu 
    1370                 1375                 1380             


Ser Val  Gln Phe Ile Asp Tyr  Gly Asn Val Ser Val  Val His Thr 
    1385                 1390                 1395             


Asn Lys  Ile Gly Arg Leu Asp  Leu Val Asn Ala Ile  Leu Pro Gly 
    1400                 1405                 1410             


Leu Cys  Ile His Cys Ser Leu  Gln Gly Phe Glu Val  Pro Asp Asn 
    1415                 1420                 1425             


Lys Asn  Ser Lys Lys Met Met  His Tyr Phe Ser Gln  Arg Thr Ser 
    1430                 1435                 1440             


Glu Ala  Ala Ile Arg Cys Glu  Phe Val Lys Phe Gln  Asp Arg Trp 
    1445                 1450                 1455             


Glu Val  Ile Leu Ala Asp Glu  His Gly Ile Ile Ala  Asp Asp Met 
    1460                 1465                 1470             


Ile Ser  Arg Tyr Ala Leu Ser  Glu Lys Ser Gln Val  Glu Leu Ser 
    1475                 1480                 1485             


Thr Gln  Val Ile Lys Ser Ala  Ser Ser Lys Ser Val  Asn Lys Ser 
    1490                 1495                 1500             


Asp Ile  Asp Thr Ser Val Phe  Leu Asn Trp Tyr Asn  Pro Glu Lys 
    1505                 1510                 1515             


Lys Met  Ile Arg Ala Tyr Ala  Thr Val Ile Asp Gly  Pro Glu Tyr 
    1520                 1525                 1530             


Phe Trp  Cys Gln Phe Ala Asp  Thr Glu Lys Leu Gln  Cys Leu Glu 
    1535                 1540                 1545             


Val Glu  Val Gln Thr Ala Gly  Glu Gln Val Ala Asp  Arg Arg Asn 
    1550                 1555                 1560             


Cys Ile  Pro Cys Pro Tyr Ile  Gly Asp Pro Cys Ile  Val Arg Tyr 
    1565                 1570                 1575             


Arg Glu  Asp Gly His Tyr Tyr  Arg Ala Leu Ile Thr  Asn Ile Cys 
    1580                 1585                 1590             


Glu Asp  Tyr Leu Val Ser Val  Arg Leu Val Asp Phe  Gly Asn Ile 
    1595                 1600                 1605             


Glu Asp  Cys Val Asp Pro Lys  Ala Leu Trp Ala Ile  Pro Ser Glu 
    1610                 1615                 1620             


Leu Leu  Ser Val Pro Met Gln  Ala Phe Pro Cys Cys  Leu Ser Gly 
    1625                 1630                 1635             


Phe Asn  Ile Ser Glu Gly Leu  Cys Ser Gln Glu Gly  Asn Asp Tyr 
    1640                 1645                 1650             


Phe Tyr  Glu Ile Ile Thr Glu  Asp Val Leu Glu Ile  Thr Ile Leu 
    1655                 1660                 1665             


Glu Ile  Arg Arg Asp Val Cys  Asp Ile Pro Leu Ala  Ile Val Asp 
    1670                 1675                 1680             


Leu Lys  Ser Lys Gly Lys Ser  Ile Asn Glu Lys Met  Glu Lys Tyr 
    1685                 1690                 1695             


Ser Lys  Thr Gly Ile Lys Ser  Ala Leu Pro Tyr Glu  Asn Ile Asp 
    1700                 1705                 1710             


Ser Glu  Ile Lys Gln Thr Leu  Gly Ser Tyr Asn Leu  Asp Val Gly 
    1715                 1720                 1725             


Leu Lys  Lys Leu Ser Asn Lys  Ala Val Gln Asn Lys  Ile Tyr Met 
    1730                 1735                 1740             


Glu Gln  Gln Thr Asp Glu Leu  Ala Glu Ile Thr Glu  Lys Asp Val 
    1745                 1750                 1755             


Asn Ile  Ile Gly Thr Lys Pro  Ser Asn Phe Arg Asp  Pro Lys Thr 
    1760                 1765                 1770             


Asp Asn  Ile Cys Glu Gly Phe  Glu Asn Pro Cys Lys  Asp Lys Ile 
    1775                 1780                 1785             


Asp Thr  Glu Glu Leu Glu Gly  Glu Leu Glu Cys His  Leu Val Asp 
    1790                 1795                 1800             


Lys Ala  Glu Phe Asp Asp Lys  Tyr Leu Ile Thr Gly  Phe Asn Thr 
    1805                 1810                 1815             


Leu Leu  Pro His Ala Asn Glu  Thr Lys Glu Ile Leu  Glu Leu Asn 
    1820                 1825                 1830             


Ser Leu  Glu Val Pro Leu Ser  Pro Asp Asp Glu Ser  Lys Glu Phe 
    1835                 1840                 1845             


Leu Glu  Leu Glu Ser Ile Glu  Leu Gln Asn Ser Leu  Val Val Asp 
    1850                 1855                 1860             


Glu Glu  Lys Gly Glu Leu Ser  Pro Val Pro Pro Asn  Val Pro Leu 
    1865                 1870                 1875             


Ser Gln  Glu Cys Val Thr Lys  Gly Ala Met Glu Leu  Phe Thr Leu 
    1880                 1885                 1890             


Gln Leu  Pro Leu Ser Cys Glu  Ala Glu Lys Gln Pro  Glu Leu Glu 
    1895                 1900                 1905             


Leu Pro  Thr Ala Gln Leu Pro  Leu Asp Asp Lys Met  Asp Pro Leu 
    1910                 1915                 1920             


Ser Leu  Gly Val Ser Gln Lys  Ala Gln Glu Ser Met  Cys Thr Glu 
    1925                 1930                 1935             


Asp Met  Arg Lys Ser Ser Cys  Val Glu Ser Phe Asp  Asp Gln Arg 
    1940                 1945                 1950             


Arg Met  Ser Leu His Leu His  Gly Ala Asp Cys Asp  Pro Lys Thr 
    1955                 1960                 1965             


Gln Asn  Glu Met Asn Ile Cys  Glu Glu Glu Phe Val  Glu Tyr Lys 
    1970                 1975                 1980             


Asn Arg  Asp Ala Ile Ser Ala  Leu Met Pro Leu Phe  Ser Glu Glu 
    1985                 1990                 1995             


Glu Ser  Ser Asp Gly Ser Lys  His Asn Asn Gly Leu  Pro Asp His 
    2000                 2005                 2010             


Ile Ser  Ala Gln Leu Gln Asn  Thr Tyr Thr Leu Lys  Ala Phe Thr 
    2015                 2020                 2025             


Val Gly  Ser Lys Cys Val Val  Trp Ser Ser Leu Arg  Asn Thr Trp 
    2030                 2035                 2040             


Ser Lys  Cys Glu Ile Leu Glu  Thr Ala Glu Glu Gly  Thr Arg Lys 
    2045                 2050                 2055             


Arg Gly  Leu Glu Val Met Glu  Ile 
    2060                 2065     


<210> 8949
<211> 87
<212> PRT
<213> Homo sapiens

<400> 8949
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly 
                85          


<210> 8950
<211> 822
<212> PRT
<213> Homo sapiens

<400> 8950
Met Ala Ala Glu Gly Asp Pro Glu Trp Gly Pro Thr Pro Pro Ser Thr 
1               5                   10                  15      


Ser Ala Thr Thr Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp 
            20                  25                  30          


Asp His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Thr Gln Asp Ser Glu 
    50                  55                  60                  


Asp Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr 
65                  70                  75                  80  


Pro Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Thr Glu 
                85                  90                  95      


Ser Ser Phe Arg Ser His Ser Thr Tyr Ser Ser Thr Pro Gly Arg Arg 
            100                 105                 110         


Lys Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp 
        115                 120                 125             


Ile Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro 
    130                 135                 140                 


Asn Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn 
145                 150                 155                 160 


Phe Gly Thr Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys 
                165                 170                 175     


Ala Ala Leu Val Ser Gln Glu Gln Cys Thr Leu Met Ala Glu Met His 
            180                 185                 190         


Val Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Thr Ser Asn Thr 
        195                 200                 205             


Thr Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Thr Leu Tyr 
    210                 215                 220                 


Phe Ile Asp Gly Met Thr Trp Pro Glu Val Leu Arg Val Tyr Cys Glu 
225                 230                 235                 240 


Ser Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp 
                245                 250                 255     


Tyr Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu 
            260                 265                 270         


Val Asp Gln Phe Leu Thr Thr Asn Ile Ala Arg Glu Glu Leu Met Ser 
        275                 280                 285             


Glu Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu 
    290                 295                 300                 


Gly Asp Leu Leu Cys Cys Glu Thr Cys Ser Ala Val Tyr His Leu Glu 
305                 310                 315                 320 


Cys Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys 
                325                 330                 335     


Glu Val Cys Val Ala His Lys Val Pro Gly Val Thr Asp Cys Val Ala 
            340                 345                 350         


Glu Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr 
        355                 360                 365             


Asp Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile 
    370                 375                 380                 


Glu Glu Asp Thr Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser 
385                 390                 395                 400 


Thr Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr 
                405                 410                 415     


Trp Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile 
            420                 425                 430         


His Arg His Met Asp Ile Thr Glu Asp Leu Thr Asn Lys Ala Arg Gly 
        435                 440                 445             


Ser Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser 
    450                 455                 460                 


Ile Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu 
465                 470                 475                 480 


Thr Glu Lys Asp Lys Asn Glu Thr Glu Asn Asp Ser Lys Asp Ala Glu 
                485                 490                 495     


Lys Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp 
            500                 505                 510         


Asp Lys Thr Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Glu Pro 
        515                 520                 525             


Thr Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala Asn Leu Gly Asp 
    530                 535                 540                 


Asn Thr Thr Asn Ala Thr Ser Glu Glu Thr Ser Pro Ser Glu Gly Arg 
545                 550                 555                 560 


Ser Pro Val Gly Cys Leu Ser Glu Thr Pro Asp Ser Ser Asn Met Ala 
                565                 570                 575     


Glu Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val Pro Glu Glu Pro 
            580                 585                 590         


Asn Lys Thr Cys Glu Ser Ser Asn Thr Ser Ala Thr Thr Thr Ser Ile 
        595                 600                 605             


Gln Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser Glu Leu Asn Ser Ser 
    610                 615                 620                 


Gln Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro Glu Asn Gly Glu Arg 
625                 630                 635                 640 


Glu Ser His Thr Pro Val Ser Ile Gln Glu Glu Ile Val Gly Asp Phe 
                645                 650                 655     


Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala Gly 
            660                 665                 670         


Lys Gly Ala Ser Gly Ser Thr Arg Ile Ile Thr Arg Leu Arg Asn Pro 
        675                 680                 685             


Asp Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala Ala 
    690                 695                 700                 


His Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val Val 
705                 710                 715                 720 


Asn Ser Gln Gly Glu Ile Ser Arg Leu Ser Thr Lys Lys Glu Val Ile 
                725                 730                 735     


Met Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly Lys 
            740                 745                 750         


Tyr Arg Val Tyr His Asn Gln Tyr Ser Thr Asn Ser Phe Ala Leu Asn 
        755                 760                 765             


Lys His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala His 
    770                 775                 780                 


Lys Phe Cys Leu Thr Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser Val 
785                 790                 795                 800 


His Gly Ser Lys Val Leu Thr Ile Ser Thr Leu Arg Leu Thr Ile Thr 
                805                 810                 815     


Gln Tyr Gly Glu Asn Leu 
            820         


<210> 8951
<211> 183
<212> PRT
<213> Homo sapiens

<400> 8951
Met Leu Gln Gln Thr Trp Thr Ser Arg Cys Leu Met Lys Phe Tyr Ala 
1               5                   10                  15      


Val Val Ala Thr Ser Pro Ala Ser Trp Glu Ser His Lys Ile Ala Glu 
            20                  25                  30          


Arg Ile Glu Gln Arg Ile Leu Asn Ser Asn Pro Val Met Glu Ala Phe 
        35                  40                  45              


Gly Asn Ala Cys Thr Leu Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys 
    50                  55                  60                  


Phe Ile Gln Leu Gln Leu Asn Arg Ala Gln Gln Met Thr Gly Ala Ala 
65                  70                  75                  80  


Val Gln Thr Tyr Leu Leu Glu Lys Thr Arg Val Ala Cys Gln Ala Ser 
                85                  90                  95      


Ser Glu Arg Asn Phe His Ile Phe Tyr Gln Ile Cys Lys Gly Ala Ser 
            100                 105                 110         


Glu Asp Glu Arg Leu Gln Trp His Leu Pro Glu Gly Ala Ala Phe Ser 
        115                 120                 125             


Trp Leu Pro Asn Pro Glu Arg Ser Leu Glu Glu Asp Cys Phe Glu Val 
    130                 135                 140                 


Thr Arg Glu Ala Met Leu His Leu Gly Ile Asp Thr Pro Thr Gln Asn 
145                 150                 155                 160 


Asn Ile Phe Lys Val Arg Arg Lys Ala Thr Pro Leu Lys Phe Gly Arg 
                165                 170                 175     


Asp Asp Gly Gln Pro Phe Ala 
            180             


<210> 8952
<211> 247
<212> PRT
<213> Homo sapiens

<400> 8952
Met Leu Lys Phe Leu Val Trp Phe Leu Gln Trp Cys Val Cys Val Leu 
1               5                   10                  15      


Val Gln Pro Ala Lys Glu Leu Leu His Cys Leu Lys Met Gln Met Arg 
            20                  25                  30          


Ile Ser Lys Tyr Thr Lys Cys Leu Gln Ala Gln Ile Ala Ile Thr Val 
        35                  40                  45              


Pro Lys Thr Trp Lys Lys Pro Lys Asp Arg Thr Arg Thr Thr Glu Glu 
    50                  55                  60                  


Met Leu Glu Ala Glu Leu Glu Leu Lys Ala Glu Glu Glu Leu Ser Ile 
65                  70                  75                  80  


Asp Lys Val Leu Glu Ser Glu Gln Asp Lys Met Ser Gln Gly Phe His 
                85                  90                  95      


Pro Glu Arg Asp Pro Ser Asp Leu Lys Lys Val Lys Ala Val Glu Glu 
            100                 105                 110         


Asn Gly Glu Glu Ala Glu Pro Val Arg Asn Gly Ala Glu Ser Val Ser 
        115                 120                 125             


Glu Gly Glu Gly Ile Asp Ala Asn Ser Gly Ser Thr Asp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Val Thr Phe Pro Phe Lys Pro Glu Ser Trp Lys Pro Thr Asp 
145                 150                 155                 160 


Thr Glu Gly Lys Lys Gln Tyr Asp Arg Glu Phe Leu Leu Asp Phe Gln 
                165                 170                 175     


Phe Met Pro Ala Cys Ile Gln Lys Pro Glu Gly Leu Pro Pro Ile Ser 
            180                 185                 190         


Asp Val Val Leu Asp Lys Ile Asn Gln Pro Lys Leu Pro Met Arg Thr 
        195                 200                 205             


Leu Asp Pro Arg Ile Leu Pro Arg Gly Pro Asp Phe Thr Pro Ala Phe 
    210                 215                 220                 


Ala Asp Phe Gly Arg Gln Thr Pro Gly Gly Arg Gly Val Pro Val Ser 
225                 230                 235                 240 


Ala Ser Ser Leu Gln Leu Thr 
                245         


<210> 8953
<211> 326
<212> PRT
<213> Homo sapiens

<400> 8953
Met Leu Gly Gly Val Gly Glu Glu Asn Glu Lys Leu Trp Ser Phe Thr 
1               5                   10                  15      


Lys Lys Ala Ser His Ile Gln Leu Asp Ser Leu Pro Glu Val Pro Leu 
            20                  25                  30          


Leu Val Asp Val Pro Cys Leu Ser Ala Gln Leu Asp Asp Ser Ile Leu 
        35                  40                  45              


Asn Ile Val Lys Asp His Ile Phe Lys His Gly Thr Val Ala Ser Arg 
    50                  55                  60                  


Pro Pro Val Gln Ile Glu Glu Leu Ile Glu Lys Pro Gly Gly Ile Ile 
65                  70                  75                  80  


Val Arg Trp Cys Lys Val Asp Asp Asp Phe Thr Ala Gln Asp Tyr Arg 
                85                  90                  95      


Leu Gln Phe Arg Lys Cys Thr Ser Asn His Phe Glu Asp Val Tyr Val 
            100                 105                 110         


Gly Ser Glu Thr Glu Phe Ile Val Leu His Ile Asp Pro Asn Val Asp 
        115                 120                 125             


Tyr Gln Phe Arg Val Cys Ala Arg Gly Asp Gly Arg Gln Glu Trp Ser 
    130                 135                 140                 


Pro Trp Ser Val Pro Gln Ile Gly His Ser Thr Leu Val Pro His Glu 
145                 150                 155                 160 


Trp Thr Ala Gly Phe Glu Gly Tyr Ser Leu Ser Ser Arg Arg Asn Ile 
                165                 170                 175     


Ala Leu Arg Asn Asp Ser Glu Ser Ser Gly Val Leu Tyr Ser Arg Ala 
            180                 185                 190         


Pro Thr Tyr Phe Cys Gly Gln Thr Leu Thr Phe Arg Val Glu Thr Val 
        195                 200                 205             


Gly Gln Pro Asp Arg Arg Asp Ser Ile Gly Val Cys Ala Glu Lys Gln 
    210                 215                 220                 


Asp Gly Tyr Asp Ser Leu Gln Arg Asp Gln Ala Val Cys Ile Ser Thr 
225                 230                 235                 240 


Asn Gly Ala Val Phe Val Asn Gly Lys Glu Met Thr Asn Gln Leu Pro 
                245                 250                 255     


Ala Val Thr Ser Gly Ser Thr Val Thr Phe Asp Ile Glu Ala Val Thr 
            260                 265                 270         


Leu Gly Thr Thr Ser Asn Asn Glu Gly Gly His Phe Lys Leu Arg Val 
        275                 280                 285             


Thr Ile Ser Ser Asn Asn Arg Glu Val Val Phe Asp Trp Leu Leu Asp 
    290                 295                 300                 


Gln Ser Cys Gly Ser Leu Tyr Phe Gly Cys Ser Phe Phe Tyr Pro Gly 
305                 310                 315                 320 


Trp Lys Val Leu Val Phe 
                325     


<210> 8954
<211> 811
<212> PRT
<213> Homo sapiens

<400> 8954
Met Val Ser Glu Glu Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Thr 
1               5                   10                  15      


Gln Asp Ser Glu Asp Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp 
            20                  25                  30          


Asp Ser Asp Tyr Pro Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser 
        35                  40                  45              


Tyr Cys Thr Glu Ser Ser Phe Arg Ser His Ser Thr Tyr Ser Ser Thr 
    50                  55                  60                  


Pro Gly Arg Arg Lys Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu 
65                  70                  75                  80  


Glu Glu Lys Asp Ile Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp 
                85                  90                  95      


Leu Met Val Pro Asn Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu 
            100                 105                 110         


Val Leu Arg Asn Phe Gly Thr Val Leu Arg Leu Ser Pro Phe Arg Phe 
        115                 120                 125             


Glu Asp Phe Cys Ala Ala Leu Val Ser Gln Glu Gln Cys Thr Leu Met 
    130                 135                 140                 


Ala Glu Met His Val Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp 
145                 150                 155                 160 


Thr Ser Asn Thr Thr Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn 
                165                 170                 175     


Ser Thr Leu Tyr Phe Ile Asp Gly Met Thr Trp Pro Glu Val Leu Arg 
            180                 185                 190         


Val Tyr Cys Glu Ser Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln 
        195                 200                 205             


Glu Ala Glu Asp Tyr Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val 
    210                 215                 220                 


Leu Gln Phe Leu Val Asp Gln Phe Leu Thr Thr Asn Ile Ala Arg Glu 
225                 230                 235                 240 


Glu Leu Met Ser Glu Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val 
                245                 250                 255     


Cys His Lys Leu Gly Asp Leu Leu Cys Cys Glu Thr Cys Ser Ala Val 
            260                 265                 270         


Tyr His Leu Glu Cys Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp 
        275                 280                 285             


Glu Trp Gln Cys Glu Val Cys Val Ala His Lys Val Pro Gly Val Thr 
    290                 295                 300                 


Asp Cys Val Ala Glu Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu 
305                 310                 315                 320 


Pro Ile Gly Tyr Asp Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg 
                325                 330                 335     


Arg Leu Ile Ile Glu Glu Asp Thr Glu Asn Glu Asn Glu Lys Lys Ile 
            340                 345                 350         


Trp Tyr Tyr Ser Thr Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu 
        355                 360                 365             


Asp Lys Asp Tyr Trp Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met 
    370                 375                 380                 


Arg Glu Glu Ile His Arg His Met Asp Ile Thr Glu Asp Leu Thr Asn 
385                 390                 395                 400 


Lys Ala Arg Gly Ser Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu 
                405                 410                 415     


Ile Leu Glu Ser Ile Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys 
            420                 425                 430         


Ser Pro Glu Glu Thr Glu Lys Asp Lys Asn Glu Thr Glu Asn Asp Ser 
        435                 440                 445             


Lys Asp Ala Glu Lys Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu 
    450                 455                 460                 


Lys Asp Ser Asp Asp Lys Thr Pro Asp Asp Asp Pro Glu Gln Gly Lys 
465                 470                 475                 480 


Ser Glu Glu Pro Thr Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala 
                485                 490                 495     


Asn Leu Gly Asp Asn Thr Thr Asn Ala Thr Ser Glu Glu Thr Ser Pro 
            500                 505                 510         


Ser Glu Gly Arg Ser Pro Val Gly Cys Leu Ser Glu Thr Pro Asp Ser 
        515                 520                 525             


Ser Asn Met Ala Glu Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val 
    530                 535                 540                 


Pro Val Gly Asp Phe Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu 
545                 550                 555                 560 


Ser Pro Gly Ala Gly Lys Gly Ala Ser Gly Ser Thr Arg Ile Ile Thr 
                565                 570                 575     


Arg Leu Arg Asn Pro Asp Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln 
            580                 585                 590         


Val Ala Ala Ala Ala His Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys 
        595                 600                 605             


Glu Val Leu Val Val Asn Ser Gln Gly Glu Ile Ser Arg Leu Ser Thr 
    610                 615                 620                 


Lys Lys Glu Val Ile Met Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu 
625                 630                 635                 640 


Gly Gln Glu Gly Lys Tyr Arg Val Tyr His Asn Gln Tyr Ser Thr Asn 
                645                 650                 655     


Ser Phe Ala Leu Asn Lys His Gln His Arg Glu Asp His Asp Lys Arg 
            660                 665                 670         


Arg His Leu Ala His Lys Phe Cys Leu Thr Pro Ala Gly Glu Phe Lys 
        675                 680                 685             


Trp Asn Gly Ser Val His Gly Ser Lys Val Leu Thr Ile Ser Thr Leu 
    690                 695                 700                 


Arg Leu Thr Ile Thr Gln Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu 
705                 710                 715                 720 


His Pro Asn Trp Ala Ser His Arg Ala Asn Trp Ile Lys Ala Val Gln 
                725                 730                 735     


Met Cys Ser Lys Pro Arg Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu 
            740                 745                 750         


Cys Ala Val Lys Pro Val Val Met Leu Pro Ile Trp Arg Glu Ser Leu 
        755                 760                 765             


Gly His Thr Arg Leu His Arg Met Thr Ser Ile Glu Arg Glu Glu Lys 
    770                 775                 780                 


Glu Lys Val Lys Lys Arg Glu Glu Thr Gly Arg Arg Arg Asn Asp Ala 
785                 790                 795                 800 


Ala Ser Asp Met Gly Lys Ile His Ile Ser Ser 
                805                 810     


<210> 8955
<211> 583
<212> PRT
<213> Homo sapiens

<400> 8955
Met Ala Pro Glu Leu Thr Pro Glu Glu Glu Gln Ala Thr Lys Gln Phe 
1               5                   10                  15      


Leu Glu Glu Ile Asn Lys Trp Thr Val Gln Tyr Asn Val Ser Pro Leu 
            20                  25                  30          


Ser Trp Asn Val Ala Val Lys Phe Leu Met Ala Arg Lys Phe Asp Val 
        35                  40                  45              


Leu Arg Ala Ile Glu Leu Phe His Ser Tyr Arg Glu Thr Arg Arg Lys 
    50                  55                  60                  


Glu Gly Ile Val Lys Leu Lys Pro His Glu Glu Pro Leu Arg Ser Glu 
65                  70                  75                  80  


Ile Leu Ser Gly Lys Phe Thr Ile Leu Asn Val Arg Asp Pro Thr Gly 
                85                  90                  95      


Ala Ser Ile Ala Leu Phe Thr Ala Arg Leu His His Pro His Lys Ser 
            100                 105                 110         


Val Gln His Val Val Leu Gln Ala Leu Phe Tyr Leu Leu Asp Arg Ala 
        115                 120                 125             


Val Asp Ser Phe Glu Thr Gln Arg Asn Gly Leu Val Phe Ile Tyr Asp 
    130                 135                 140                 


Met Cys Gly Ser Asn Tyr Ala Asn Phe Glu Leu Asp Leu Gly Lys Lys 
145                 150                 155                 160 


Val Leu Asn Leu Leu Lys Gly Ala Phe Pro Ala Arg Leu Lys Lys Val 
                165                 170                 175     


Leu Ile Val Gly Ala Pro Ile Trp Phe Arg Val Pro Tyr Ser Ile Ile 
            180                 185                 190         


Ser Leu Leu Leu Lys Asp Lys Val Arg Glu Arg Ile Gln Ile Leu Lys 
        195                 200                 205             


Thr Ser Glu Val Thr Gln His Leu Pro Arg Glu Cys Leu Pro Glu Asn 
    210                 215                 220                 


Leu Gly Gly Tyr Val Lys Ile Asp Leu Ala Thr Trp Asn Phe Gln Phe 
225                 230                 235                 240 


Leu Pro Gln Val Asn Gly His Pro Asp Pro Phe Asp Glu Ile Ile Leu 
                245                 250                 255     


Phe Ser Leu Pro Pro Ala Leu Asp Trp Asp Ser Val His Val Pro Gly 
            260                 265                 270         


Pro His Ala Met Thr Ile Gln Glu Leu Val Asp Tyr Val Asn Ala Arg 
        275                 280                 285             


Gln Lys Gln Gly Ile Tyr Glu Glu Tyr Glu Asp Ile Arg Arg Glu Asn 
    290                 295                 300                 


Pro Val Gly Thr Phe His Cys Ser Met Ser Pro Gly Asn Leu Glu Lys 
305                 310                 315                 320 


Asn Arg Tyr Gly Asp Val Pro Cys Leu Asp Gln Thr Arg Val Lys Leu 
                325                 330                 335     


Thr Lys Arg Ser Gly His Thr Gln Thr Asp Tyr Ile Asn Ala Ser Phe 
            340                 345                 350         


Met Asp Gly Tyr Lys Gln Lys Asn Ala Tyr Ile Gly Thr Gln Gly Pro 
        355                 360                 365             


Leu Glu Asn Thr Tyr Arg Asp Phe Trp Leu Met Val Trp Glu Gln Lys 
    370                 375                 380                 


Val Leu Val Ile Val Met Thr Thr Arg Phe Glu Glu Gly Gly Arg Arg 
385                 390                 395                 400 


Lys Cys Gly Gln Tyr Trp Pro Leu Glu Lys Asp Ser Arg Ile Arg Phe 
                405                 410                 415     


Gly Phe Leu Thr Val Thr Asn Leu Gly Val Glu Asn Met Asn His Tyr 
            420                 425                 430         


Lys Lys Thr Thr Leu Glu Ile His Asn Thr Glu Glu Arg Gln Lys Arg 
        435                 440                 445             


Gln Val Thr His Phe Gln Phe Leu Ser Trp Pro Asp Tyr Gly Val Pro 
    450                 455                 460                 


Ser Ser Ala Ala Ser Leu Ile Asp Phe Leu Arg Val Val Arg Asn Gln 
465                 470                 475                 480 


Gln Ser Leu Ala Val Ser Asn Met Gly Ala Arg Ser Lys Gly Gln Cys 
                485                 490                 495     


Pro Glu Pro Pro Ile Val Val His Cys Ser Ala Gly Ile Gly Arg Thr 
            500                 505                 510         


Gly Thr Phe Cys Ser Leu Asp Ile Cys Leu Ala Gln Leu Glu Glu Leu 
        515                 520                 525             


Gly Thr Leu Asn Val Phe Gln Thr Val Ser Arg Met Arg Thr Gln Arg 
    530                 535                 540                 


Ala Phe Ser Ile Gln Thr Pro Glu Gln Tyr Tyr Phe Cys Tyr Lys Ala 
545                 550                 555                 560 


Ile Leu Glu Phe Ala Glu Lys Glu Gly Met Val Ser Ser Gly Gln Asn 
                565                 570                 575     


Leu Leu Ala Val Glu Ser Gln 
            580             


<210> 8956
<211> 131
<212> PRT
<213> Homo sapiens

<400> 8956
Met Ala Met Thr Ala Gly Thr Thr Thr Thr Phe Pro Met Ser Asn His 
1               5                   10                  15      


Thr Arg Glu Arg Val Thr Val Ala Lys Leu Thr Leu Glu Asn Phe Tyr 
            20                  25                  30          


Ser Asn Leu Ile Leu Gln His Glu Glu Arg Glu Thr Arg Gln Lys Lys 
        35                  40                  45              


Leu Glu Val Ala Met Glu Glu Glu Gly Leu Ala Asp Glu Glu Lys Lys 
    50                  55                  60                  


Leu Arg Arg Ser Gln His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Arg Leu Gly Leu Asp Asp Phe Glu Ser Leu Lys Val Ile 
                85                  90                  95      


Gly Arg Gly Ala Phe Gly Glu Val Arg Leu Val Gln Lys Lys Asp Thr 
            100                 105                 110         


Gly His Ile Tyr Ala Met Lys Ile Leu Arg Lys Ser Asp Met Leu Glu 
        115                 120                 125             


Lys Glu Gln 
    130     


<210> 8957
<211> 144
<212> PRT
<213> Homo sapiens

<400> 8957
Met Ala Ser Val Ala Ala Ala Arg Ala Val Pro Val Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Arg Thr Leu Pro Leu Val Val Ile Leu Gly Ala Thr 
            20                  25                  30          


Gly Thr Gly Lys Ser Thr Leu Ala Leu Gln Leu Gly Gln Arg Leu Gly 
        35                  40                  45              


Gly Glu Ile Val Ser Ala Asp Ser Met Gln Val Tyr Glu Gly Leu Asp 
    50                  55                  60                  


Ile Ile Thr Asn Lys Val Ser Ala Gln Glu Gln Arg Ile Cys Arg His 
65                  70                  75                  80  


His Met Ile Ser Phe Val Asp Pro Leu Val Thr Asn Tyr Thr Val Val 
                85                  90                  95      


Asp Phe Arg Asn Arg Ala Thr Ala Leu Ile Glu Asp Ile Phe Ala Arg 
            100                 105                 110         


Asp Lys Ile Pro Ile Val Val Gly Gly Thr Asn Tyr Tyr Ile Glu Ser 
        115                 120                 125             


Leu Leu Trp Lys Val Leu Val Asn Thr Lys Val Ser Leu Val His Ser 
    130                 135                 140                 


<210> 8958
<211> 461
<212> PRT
<213> Homo sapiens

<400> 8958
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys 
1               5                   10                  15      


Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu 
            20                  25                  30          


Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala 
        35                  40                  45              


Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His 
    50                  55                  60                  


Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr 
65                  70                  75                  80  


Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu 
                85                  90                  95      


Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Val 
            100                 105                 110         


Pro Pro Ser Leu Trp Arg Gly Glu Gly Gly Gly Pro Ala Arg Leu Asp 
        115                 120                 125             


Pro Ser Trp Glu Arg Gln Trp Gly Ala Gly Gly Gly Gly Arg Pro Gly 
    130                 135                 140                 


Thr Leu Gln Pro Ser Leu Ser Ser Gln Arg Tyr Gln Ala Glu Ile Asn 
145                 150                 155                 160 


Asp Leu Glu Asn Leu Gly Glu Met Gly Ser Gly Thr Cys Gly Gln Val 
                165                 170                 175     


Trp Lys Met Arg Phe Arg Lys Thr Gly His Val Ile Ala Val Lys Gln 
            180                 185                 190         


Met Arg Arg Ser Gly Asn Lys Glu Glu Asn Lys Arg Ile Leu Met Asp 
        195                 200                 205             


Leu Asp Val Val Leu Lys Ser His Asp Cys Pro Tyr Ile Val Gln Cys 
    210                 215                 220                 


Phe Gly Thr Phe Ile Thr Asn Thr Asp Val Phe Ile Ala Met Glu Leu 
225                 230                 235                 240 


Met Gly Thr Cys Ala Glu Lys Leu Lys Lys Arg Met Gln Gly Pro Ile 
                245                 250                 255     


Pro Glu Arg Ile Leu Gly Lys Met Thr Val Ala Ile Val Lys Ala Leu 
            260                 265                 270         


Tyr Tyr Leu Lys Glu Lys His Gly Val Ile His Arg Asp Val Lys Pro 
        275                 280                 285             


Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln Ile Lys Leu Cys Asp Phe 
    290                 295                 300                 


Gly Ile Ser Gly Arg Leu Val Asp Ser Lys Ala Lys Thr Arg Ser Ala 
305                 310                 315                 320 


Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg Ile Asp Pro Pro Asp Pro 
                325                 330                 335     


Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp Val Trp Ser Leu Gly Ile 
            340                 345                 350         


Ser Leu Val Glu Leu Ala Thr Gly Gln Phe Pro Tyr Lys Asn Cys Lys 
        355                 360                 365             


Thr Asp Phe Glu Val Leu Thr Lys Val Leu Gln Glu Glu Pro Pro Leu 
    370                 375                 380                 


Leu Pro Gly His Met Gly Phe Ser Gly Asp Phe Gln Ser Phe Val Lys 
385                 390                 395                 400 


Asp Cys Leu Thr Lys Asp His Arg Lys Arg Pro Lys Tyr Asn Lys Leu 
                405                 410                 415     


Leu Glu His Ser Phe Ile Lys Arg Tyr Glu Thr Leu Glu Val Asp Val 
            420                 425                 430         


Ala Ser Trp Phe Lys Asp Val Met Ala Lys Thr Glu Ser Pro Arg Thr 
        435                 440                 445             


Ser Gly Val Leu Ser Gln Pro His Leu Pro Phe Phe Arg 
    450                 455                 460     


<210> 8959
<211> 536
<212> PRT
<213> Homo sapiens

<400> 8959
Met Glu Thr Ser Asp Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys 
1               5                   10                  15      


Gln Asn Leu Ser Glu Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr 
            20                  25                  30          


Asn Leu Tyr Ser Pro Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala 
        35                  40                  45              


Leu Pro Ala Met Lys Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly 
    50                  55                  60                  


Cys Gly Lys Thr Phe Val Ser Leu Leu Ile Cys Glu His His Leu Lys 
65                  70                  75                  80  


Lys Phe Pro Gln Gly Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln 
                85                  90                  95      


Ile Pro Val Tyr Glu Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu 
            100                 105                 110         


Arg His Gly Tyr Arg Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn 
        115                 120                 125             


Val Pro Val Glu Gln Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr 
    130                 135                 140                 


Pro Gln Ile Leu Val Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu 
145                 150                 155                 160 


Ser Ile Phe Thr Leu Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys 
                165                 170                 175     


Gln His Pro Tyr Asn Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu 
            180                 185                 190         


Gly Gly Ser Ser Gly Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser 
        195                 200                 205             


Val Gly Val Gly Asp Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile 
    210                 215                 220                 


Cys Lys Leu Cys Ala Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys 
225                 230                 235                 240 


His Asn Leu Glu Glu Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe 
                245                 250                 255     


Phe Arg Lys Val Glu Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile 
            260                 265                 270         


Ala Gln Leu Met Arg Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys 
        275                 280                 285             


Asp Leu Glu Asn Leu Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln 
    290                 295                 300                 


Lys Tyr Glu Gln Trp Ile Val Thr Val Gln Lys Ala Cys Met Val Phe 
305                 310                 315                 320 


Gln Met Pro Asp Lys Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe 
                325                 330                 335     


Leu Tyr Thr Ser His Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser 
            340                 345                 350         


Glu His Ala Arg Met Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe 
        355                 360                 365             


Ser Asn Val Arg Ala Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr 
    370                 375                 380                 


Gln Arg Phe Glu Glu Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp 
385                 390                 395                 400 


Pro Ser Asn Glu Asn Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln 
                405                 410                 415     


Glu Glu Tyr His Leu Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys 
            420                 425                 430         


Thr Arg Ala Leu Val Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro 
        435                 440                 445             


Lys Leu Ser Phe Leu Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr 
    450                 455                 460                 


Asn Gln Asn Thr Gly Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp 
465                 470                 475                 480 


Ala Phe Lys Ala Ser Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val 
                485                 490                 495     


Ala Asp Glu Gly Ile Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr 
            500                 505                 510         


Glu Tyr Val Gly Asn Val Ile Lys Met Ile Gln Thr Arg Glu Glu Glu 
        515                 520                 525             


Gln Glu Val Ala Ser Ala Ser Phe 
    530                 535     


<210> 8960
<211> 960
<212> PRT
<213> Homo sapiens

<400> 8960
Met Ser Arg Leu Ile Val Lys Asn Leu Pro Asn Gly Met Lys Glu Glu 
1               5                   10                  15      


Arg Phe Arg Gln Leu Phe Ala Ala Phe Gly Thr Leu Thr Asp Cys Ser 
            20                  25                  30          


Leu Lys Phe Thr Lys Asp Gly Lys Phe Arg Lys Phe Gly Phe Ile Gly 
        35                  40                  45              


Phe Lys Ser Glu Glu Glu Ala Gln Lys Ala Gln Lys His Phe Asn Lys 
    50                  55                  60                  


Ser Phe Ile Asp Thr Ser Arg Ile Thr Val Glu Phe Cys Lys Ser Phe 
65                  70                  75                  80  


Gly Asp Pro Ala Lys Pro Arg Ala Trp Ser Lys His Ala Gln Lys Pro 
                85                  90                  95      


Ser Gln Pro Lys Gln Pro Pro Lys Asp Ser Thr Thr Pro Glu Ile Lys 
            100                 105                 110         


Lys Asp Glu Lys Lys Lys Lys Val Ala Gly Gln Leu Glu Lys Leu Lys 
        115                 120                 125             


Glu Asp Thr Glu Phe Gln Glu Phe Leu Ser Val His Gln Arg Arg Ala 
    130                 135                 140                 


Gln Ala Ala Thr Trp Ala Asn Asp Gly Leu Asp Ala Glu Pro Ser Lys 
145                 150                 155                 160 


Gly Lys Ser Lys Pro Ala Ser Asp Tyr Leu Asn Phe Asp Ser Asp Ser 
                165                 170                 175     


Gly Gln Glu Ser Glu Glu Glu Gly Ala Gly Glu Asp Leu Glu Glu Glu 
            180                 185                 190         


Ala Ser Leu Glu Pro Lys Ala Ala Val Gln Lys Glu Leu Ser Asp Met 
        195                 200                 205             


Asp Tyr Leu Lys Ser Lys Met Val Lys Ala Gly Ser Ser Ser Ser Ser 
    210                 215                 220                 


Glu Glu Glu Glu Ser Glu Asp Glu Ala Val His Cys Asp Glu Gly Ser 
225                 230                 235                 240 


Glu Ala Glu Glu Glu Asp Ser Ser Ala Thr Pro Val Leu Gln Glu Arg 
                245                 250                 255     


Asp Ser Lys Gly Ala Gly Gln Glu Gln Gly Met Pro Ala Gly Lys Lys 
            260                 265                 270         


Arg Pro Pro Glu Ala Arg Ala Glu Thr Glu Lys Pro Ala Asn Gln Lys 
        275                 280                 285             


Glu Pro Thr Thr Cys His Thr Val Lys Leu Arg Gly Ala Pro Phe Asn 
    290                 295                 300                 


Val Thr Glu Lys Asn Val Met Glu Phe Leu Ala Pro Leu Lys Pro Val 
305                 310                 315                 320 


Ala Ile Arg Ile Val Arg Asn Ala His Gly Asn Lys Thr Gly Tyr Ile 
                325                 330                 335     


Phe Val Asp Phe Ser Asn Glu Glu Glu Val Lys Gln Ala Leu Lys Cys 
            340                 345                 350         


Asn Arg Glu Tyr Met Gly Gly Arg Tyr Ile Glu Val Phe Arg Glu Lys 
        355                 360                 365             


Asn Val Pro Thr Thr Lys Gly Ala Pro Lys Asn Thr Thr Lys Ser Trp 
    370                 375                 380                 


Gln Gly Arg Ile Leu Gly Glu Asn Glu Glu Glu Glu Asp Leu Ala Glu 
385                 390                 395                 400 


Ser Gly Arg Leu Phe Val Arg Asn Leu Pro Tyr Thr Ser Thr Glu Glu 
                405                 410                 415     


Asp Leu Glu Lys Leu Phe Ser Lys Tyr Gly Pro Leu Ser Glu Leu His 
            420                 425                 430         


Tyr Pro Ile Asp Ser Leu Thr Lys Lys Pro Lys Gly Phe Ala Phe Ile 
        435                 440                 445             


Thr Phe Met Phe Pro Glu His Ala Val Lys Ala Tyr Ser Glu Val Asp 
    450                 455                 460                 


Gly Gln Val Phe Gln Gly Arg Met Leu His Val Leu Pro Ser Thr Ile 
465                 470                 475                 480 


Lys Lys Glu Ala Ser Glu Asp Ala Ser Ala Leu Gly Ser Ser Ser Tyr 
                485                 490                 495     


Lys Lys Lys Lys Glu Ala Gln Asp Lys Ala Asn Ser Ala Ser Ser His 
            500                 505                 510         


Asn Trp Asn Thr Leu Phe Met Gly Pro Asn Ala Val Ala Asp Ala Ile 
        515                 520                 525             


Ala Gln Lys Tyr Asn Ala Thr Lys Ser Gln Val Phe Asp His Glu Thr 
    530                 535                 540                 


Lys Gly Ser Val Ala Val Arg Val Ala Leu Gly Glu Thr Gln Leu Val 
545                 550                 555                 560 


Gln Glu Val Arg Arg Phe Leu Ile Asp Asn Gly Val Ser Leu Asp Ser 
                565                 570                 575     


Phe Ser Gln Ala Ala Ala Glu Arg Ser Lys Thr Val Ile Leu Val Lys 
            580                 585                 590         


Asn Leu Pro Ala Gly Thr Leu Ala Ala Gln Leu Gln Glu Thr Phe Gly 
        595                 600                 605             


His Phe Gly Ser Leu Gly Arg Val Leu Leu Pro Glu Gly Gly Ile Thr 
    610                 615                 620                 


Ala Ile Val Glu Phe Leu Glu Pro Leu Glu Ala Arg Lys Ala Phe Arg 
625                 630                 635                 640 


His Leu Ala Tyr Ser Lys Phe His His Val Pro Leu Tyr Leu Glu Trp 
                645                 650                 655     


Ala Pro Val Gly Val Phe Ser Ser Thr Ala Pro Gln Lys Lys Lys Leu 
            660                 665                 670         


Gln Asp Thr Pro Ser Glu Pro Met Glu Lys Asp Pro Ala Glu Pro Glu 
        675                 680                 685             


Thr Val Pro Asp Gly Glu Thr Pro Glu Asp Glu Asn Pro Thr Glu Glu 
    690                 695                 700                 


Gly Ala Asp Asn Ser Ser Ala Lys Met Glu Glu Glu Glu Glu Glu Glu 
705                 710                 715                 720 


Glu Glu Glu Glu Glu Ser Leu Pro Gly Cys Thr Leu Phe Ile Lys Asn 
                725                 730                 735     


Leu Asn Phe Asp Thr Thr Glu Glu Lys Leu Lys Glu Val Phe Ser Lys 
            740                 745                 750         


Val Gly Thr Val Lys Ser Cys Ser Ile Ser Lys Lys Lys Asn Lys Ala 
        755                 760                 765             


Gly Val Leu Leu Ser Met Gly Phe Gly Phe Val Glu Tyr Arg Lys Pro 
    770                 775                 780                 


Glu Gln Ala Gln Lys Ala Leu Lys Gln Leu Gln Gly His Val Val Asp 
785                 790                 795                 800 


Gly His Lys Leu Glu Val Arg Ile Ser Glu Arg Ala Thr Lys Pro Ala 
                805                 810                 815     


Val Thr Leu Ala Arg Lys Lys Gln Val Pro Arg Lys Gln Thr Thr Ser 
            820                 825                 830         


Lys Ile Leu Val Arg Asn Ile Pro Phe Gln Ala His Ser Arg Glu Ile 
        835                 840                 845             


Arg Glu Leu Phe Ser Thr Phe Gly Glu Leu Lys Thr Val Arg Leu Pro 
    850                 855                 860                 


Lys Lys Met Thr Gly Thr Gly Thr His Arg Gly Phe Gly Phe Val Asp 
865                 870                 875                 880 


Phe Leu Thr Lys Gln Asp Ala Lys Arg Ala Phe Asn Ala Leu Cys His 
                885                 890                 895     


Ser Thr His Leu Tyr Gly Arg Arg Leu Val Leu Glu Trp Ala Asp Ser 
            900                 905                 910         


Glu Val Thr Leu Gln Ala Leu Arg Arg Lys Thr Ala Ala His Phe His 
        915                 920                 925             


Glu Pro Pro Lys Lys Lys Arg Ser Val Val Leu Asp Glu Ile Leu Glu 
    930                 935                 940                 


Gln Leu Glu Gly Ser Asp Ser Asp Ser Glu Glu Gln Thr Leu Gln Leu 
945                 950                 955                 960 


<210> 8961
<211> 221
<212> PRT
<213> Homo sapiens

<400> 8961
Met Leu Ala Ala Gly Leu Leu Glu Glu Leu Arg Asp Phe His Arg Arg 
1               5                   10                  15      


Tyr Asn Gln Lys Asn Val Ser Glu Asn Ser Gln Asp Tyr Gln His Gly 
            20                  25                  30          


Ile Phe Gln Ser Ile Gly Phe Lys Glu Phe His Glu Tyr Leu Ile Thr 
        35                  40                  45              


Glu Gly Lys Cys Thr Leu Glu Thr Ser Asn Gln Leu Leu Lys Lys Gly 
    50                  55                  60                  


Ile Glu Ala Leu Lys Gln Val Thr Lys Arg Tyr Ala Arg Lys Gln Asn 
65                  70                  75                  80  


Arg Trp Val Lys Asn Arg Phe Leu Ser Arg Pro Gly Pro Ile Val Pro 
                85                  90                  95      


Pro Val Tyr Gly Leu Glu Val Ser Asp Val Ser Lys Trp Glu Glu Ser 
            100                 105                 110         


Val Leu Glu Pro Ala Leu Glu Ile Val Gln Ser Phe Ile Gln Gly His 
        115                 120                 125             


Lys Pro Thr Ala Thr Pro Ile Lys Met Pro Tyr Asn Glu Ala Glu Asn 
    130                 135                 140                 


Lys Arg Ser Tyr His Leu Cys Asp Leu Cys Asp Arg Ile Ile Ile Gly 
145                 150                 155                 160 


Asp Arg Glu Trp Ala Ala His Ile Lys Ser Lys Ser His Leu Asn Gln 
                165                 170                 175     


Leu Lys Lys Arg Arg Arg Leu Asp Ser Asp Ala Val Asn Thr Ile Glu 
            180                 185                 190         


Ser Gln Ser Val Ser Pro Asp His Asn Lys Glu Pro Lys Glu Lys Gly 
        195                 200                 205             


Ser Pro Gly Gln Asn Asp Gln Glu Leu Lys Cys Ser Val 
    210                 215                 220     


<210> 8962
<211> 882
<212> PRT
<213> Homo sapiens

<400> 8962
Met Pro Arg Val Lys Pro Lys Leu Glu Lys Gln Leu Gln Lys Asp Lys 
1               5                   10                  15      


Glu Lys Val Glu Glu Phe Lys Ser Ile Pro Ala Lys Ser Asn Asn Ile 
            20                  25                  30          


Ile Asn Glu Thr Thr Thr Arg Asn Asn Ala Leu Glu Lys Glu Lys Glu 
        35                  40                  45              


Lys Glu Glu Lys Lys Leu Lys Glu Val Met Asp Ser Leu Lys Gln Glu 
    50                  55                  60                  


Thr Gln Gly Leu Gln Lys Glu Lys Glu Ser Arg Glu Lys Glu Leu Met 
65                  70                  75                  80  


Gly Phe Ser Lys Ser Val Asn Glu Ala Arg Ser Lys Met Asp Val Ala 
                85                  90                  95      


Gln Ser Glu Leu Asp Ile Tyr Leu Ser Arg His Asn Thr Ala Val Ser 
            100                 105                 110         


Gln Leu Thr Lys Ala Lys Glu Ala Leu Ile Ala Ala Ser Glu Thr Leu 
        115                 120                 125             


Lys Glu Arg Lys Ala Ala Ile Arg Asp Ile Glu Gly Lys Leu Pro Gln 
    130                 135                 140                 


Thr Glu Gln Glu Leu Lys Glu Lys Glu Lys Glu Leu Gln Lys Leu Thr 
145                 150                 155                 160 


Gln Glu Glu Thr Asn Phe Lys Ser Leu Val His Asp Leu Phe Gln Lys 
                165                 170                 175     


Val Glu Glu Ala Lys Ser Ser Leu Ala Met Asn Arg Ser Arg Gly Lys 
            180                 185                 190         


Val Leu Asp Ala Ile Ile Gln Glu Lys Lys Ser Gly Arg Ile Pro Gly 
        195                 200                 205             


Ile Tyr Gly Arg Leu Gly Asp Leu Gly Ala Ile Asp Glu Lys Tyr Asp 
    210                 215                 220                 


Val Ala Ile Ser Ser Cys Cys His Ala Leu Asp Tyr Ile Val Val Asp 
225                 230                 235                 240 


Ser Ile Asp Ile Ala Gln Glu Cys Val Asn Phe Leu Lys Arg Gln Asn 
                245                 250                 255     


Ile Gly Val Ala Thr Phe Ile Gly Leu Asp Lys Met Ala Val Trp Ala 
            260                 265                 270         


Lys Lys Met Thr Glu Ile Gln Thr Pro Glu Asn Thr Pro Arg Leu Phe 
        275                 280                 285             


Asp Leu Val Lys Val Lys Asp Glu Lys Ile Arg Gln Ala Phe Tyr Phe 
    290                 295                 300                 


Ala Leu Arg Asp Thr Leu Val Ala Asp Asn Leu Asp Gln Ala Thr Arg 
305                 310                 315                 320 


Val Ala Tyr Gln Lys Asp Arg Arg Trp Arg Val Val Thr Leu Gln Gly 
                325                 330                 335     


Gln Ile Ile Glu Gln Ser Gly Thr Met Thr Gly Gly Gly Ser Lys Val 
            340                 345                 350         


Met Lys Gly Arg Met Gly Ser Ser Leu Val Ile Glu Ile Ser Glu Glu 
        355                 360                 365             


Glu Val Asn Lys Met Glu Ser Gln Leu Gln Asn Asp Ser Lys Lys Ala 
    370                 375                 380                 


Met Gln Ile Gln Glu Gln Lys Val Gln Leu Glu Glu Arg Val Val Lys 
385                 390                 395                 400 


Leu Arg His Ser Glu Arg Glu Met Arg Asn Thr Leu Glu Lys Phe Thr 
                405                 410                 415     


Ala Ser Ile Gln Arg Leu Ile Glu Gln Glu Glu Tyr Leu Asn Val Gln 
            420                 425                 430         


Val Lys Glu Leu Glu Ala Asn Val Leu Ala Thr Ala Pro Asp Lys Lys 
        435                 440                 445             


Lys Gln Lys Leu Leu Glu Glu Asn Val Ser Ala Phe Lys Thr Glu Tyr 
    450                 455                 460                 


Asp Ala Val Ala Glu Lys Ala Gly Lys Val Glu Ala Glu Val Lys Arg 
465                 470                 475                 480 


Leu His Asn Thr Ile Val Glu Ile Asn Asn His Lys Leu Lys Ala Gln 
                485                 490                 495     


Gln Asp Lys Leu Asp Lys Ile Asn Lys Gln Leu Asp Glu Cys Ala Ser 
            500                 505                 510         


Ala Ile Thr Lys Ala Gln Val Ala Ile Lys Thr Ala Asp Arg Asn Leu 
        515                 520                 525             


Gln Lys Ala Gln Asp Ser Val Leu Arg Thr Glu Lys Glu Ile Lys Asp 
    530                 535                 540                 


Thr Glu Lys Glu Val Asp Asp Leu Thr Ala Glu Leu Lys Ser Leu Glu 
545                 550                 555                 560 


Asp Lys Ala Ala Glu Val Val Lys Asn Thr Asn Ala Ala Glu Glu Ser 
                565                 570                 575     


Leu Pro Glu Ile Gln Lys Glu His Arg Asn Leu Leu Gln Glu Leu Lys 
            580                 585                 590         


Val Ile Gln Glu Asn Glu His Ala Leu Gln Lys Asp Ala Leu Ser Ile 
        595                 600                 605             


Lys Leu Lys Leu Glu Gln Ile Asp Gly His Ile Ala Glu His Asn Ser 
    610                 615                 620                 


Lys Ile Lys Tyr Trp His Lys Glu Ile Ser Lys Ile Ser Leu His Pro 
625                 630                 635                 640 


Ile Glu Asp Asn Pro Ile Glu Glu Ile Ser Val Leu Ser Pro Glu Asp 
                645                 650                 655     


Leu Glu Ala Ile Lys Asn Pro Asp Ser Ile Thr Asn Gln Ile Ala Leu 
            660                 665                 670         


Leu Glu Ala Arg Cys His Glu Met Lys Pro Asn Leu Gly Ala Ile Ala 
        675                 680                 685             


Glu Tyr Lys Lys Lys Glu Glu Leu Tyr Leu Gln Arg Val Ala Glu Leu 
    690                 695                 700                 


Asp Lys Ile Thr Tyr Glu Arg Asp Ser Phe Arg Gln Ala Tyr Glu Asp 
705                 710                 715                 720 


Leu Arg Lys Gln Arg Leu Asn Glu Phe Met Ala Gly Phe Tyr Ile Ile 
                725                 730                 735     


Thr Asn Lys Leu Lys Glu Asn Tyr Gln Met Leu Thr Leu Gly Gly Asp 
            740                 745                 750         


Ala Glu Leu Glu Leu Val Asp Ser Leu Asp Pro Phe Ser Glu Gly Ile 
        755                 760                 765             


Met Phe Ser Val Arg Pro Pro Lys Lys Ser Trp Lys Lys Ile Phe Asn 
    770                 775                 780                 


Leu Ser Gly Gly Glu Lys Thr Leu Ser Ser Leu Ala Leu Val Phe Ala 
785                 790                 795                 800 


Leu His His Tyr Lys Pro Thr Pro Leu Tyr Phe Met Asp Glu Ile Asp 
                805                 810                 815     


Ala Ala Leu Asp Phe Lys Asn Val Ser Ile Val Ala Phe Tyr Ile Tyr 
            820                 825                 830         


Glu Gln Thr Lys Asn Ala Gln Phe Ile Ile Ile Ser Leu Arg Asn Asn 
        835                 840                 845             


Met Phe Glu Ile Ser Asp Arg Leu Ile Gly Ile Tyr Lys Thr Tyr Asn 
    850                 855                 860                 


Ile Thr Lys Ser Val Ala Val Asn Pro Lys Glu Ile Ala Ser Lys Gly 
865                 870                 875                 880 


Leu Cys 
        


<210> 8963
<211> 345
<212> PRT
<213> Homo sapiens

<400> 8963
Met Phe Leu Thr Arg Pro Lys Val Cys Val Asp Leu Asn Arg Arg Val 
1               5                   10                  15      


Thr Leu Tyr Gly Val Phe Thr Ile His Phe Ser Pro Asn Val Pro Ser 
            20                  25                  30          


Arg Cys Leu Leu Leu Glu Leu Leu Asp Val Ser Val Ser Glu Leu Leu 
        35                  40                  45              


Leu Tyr Ser Ser His Gln Gly Cys Ser Met Trp Met Ile Gln His Cys 
    50                  55                  60                  


Ala Arg Asp Val Leu Glu Ala Leu Ala Phe Leu His His Glu Gly Tyr 
65                  70                  75                  80  


Val His Ala Asp Leu Lys Pro Arg Asn Ile Leu Trp Ser Ala Glu Asn 
                85                  90                  95      


Glu Cys Phe Lys Leu Ile Asp Phe Gly Leu Ser Phe Lys Glu Gly Asn 
            100                 105                 110         


Gln Asp Val Lys Tyr Ile Gln Thr Asp Gly Tyr Arg Ala Pro Glu Ala 
        115                 120                 125             


Glu Leu Gln Asn Cys Leu Ala Gln Ala Gly Leu Gln Ser Asp Thr Glu 
    130                 135                 140                 


Cys Thr Ser Ala Val Asp Leu Trp Ser Leu Gly Ile Ile Leu Leu Glu 
145                 150                 155                 160 


Met Phe Ser Gly Met Lys Leu Lys His Thr Val Arg Ser Gln Glu Trp 
                165                 170                 175     


Lys Ala Asn Ser Ser Ala Ile Ile Asp His Ile Phe Ala Ser Lys Ala 
            180                 185                 190         


Val Val Asn Ala Ala Ile Pro Ala Tyr His Leu Arg Asp Leu Ile Lys 
        195                 200                 205             


Ser Met Leu His Asp Asp Pro Ser Arg Arg Ile Pro Ala Glu Met Ala 
    210                 215                 220                 


Leu Cys Ser Pro Phe Phe Ser Ile Pro Phe Ala Pro His Ile Glu Asp 
225                 230                 235                 240 


Leu Val Met Leu Pro Thr Pro Val Leu Arg Leu Leu Asn Val Leu Asp 
                245                 250                 255     


Asp Asp Tyr Leu Glu Asn Glu Glu Glu Tyr Glu Asp Val Val Glu Asp 
            260                 265                 270         


Val Lys Glu Glu Cys Gln Lys Tyr Gly Pro Val Val Ser Leu Leu Val 
        275                 280                 285             


Pro Lys Glu Asn Pro Gly Arg Gly Gln Val Phe Val Glu Tyr Ala Asn 
    290                 295                 300                 


Ala Gly Asp Ser Lys Ala Ala Gln Lys Leu Leu Thr Gly Arg Met Phe 
305                 310                 315                 320 


Asp Gly Lys Phe Val Val Ala Thr Phe Tyr Pro Leu Ser Ala Tyr Lys 
                325                 330                 335     


Arg Gly Tyr Leu Tyr Gln Thr Leu Leu 
            340                 345 


<210> 8964
<211> 317
<212> PRT
<213> Homo sapiens

<400> 8964
Met Trp Leu Ala Arg Glu Gly Ile Val Ala Pro Leu Pro Gly Glu Trp 
1               5                   10                  15      


Lys Pro Cys Gln Asp Ile Thr Gly Asp Ile Tyr Tyr Phe Asn Phe Ala 
            20                  25                  30          


Asn Gly Gln Ser Met Trp Asp His Pro Cys Asp Glu His Tyr Arg Ser 
        35                  40                  45              


Leu Val Ile Gln Glu Arg Ala Lys Leu Ser Thr Ser Gly Ala Ile Lys 
    50                  55                  60                  


Lys Lys Lys Lys Lys Lys Glu Lys Lys Asp Lys Lys Asp Arg Asp Pro 
65                  70                  75                  80  


Pro Lys Ser Ser Leu Glu Thr Gln Pro Glu Glu Gly Leu Leu Pro Pro 
                85                  90                  95      


Ser Ser Phe Leu Cys Ser Leu Ser Pro Pro Ser Ala Pro Gly Leu Ala 
            100                 105                 110         


Asp Leu Asp Leu Asp Gln Glu Met Gln Ala Ile Ser Glu Gly Ser Tyr 
        115                 120                 125             


Asn Lys Gly Lys Ser Pro Gly Met Leu Gly Asp Thr Pro Trp Arg Phe 
    130                 135                 140                 


Met Gly Ala Leu Pro Arg Lys Leu Gln Pro Leu Ser Lys Gly Gln Pro 
145                 150                 155                 160 


Ser Gln Ile His Gln Val Phe Ala Asp Met Glu Lys Ile Leu Gly Arg 
                165                 170                 175     


Ala Pro Ala Gln Cys Arg Arg Glu Leu Gly Asp Gln Gln Gly Leu Glu 
            180                 185                 190         


Lys Leu Gln Lys Ala Thr Glu Lys Ile Tyr Leu Gly Phe Ser Asp Pro 
        195                 200                 205             


Glu Thr Glu Glu Leu Glu Met Arg Ser Arg Gln Gln Lys Leu Gly Thr 
    210                 215                 220                 


Pro Ala Pro Gln Asn Thr Gly Leu Leu Gln Asn Met Gln Asp Val Val 
225                 230                 235                 240 


Glu Ser Arg Asn Gln Ala Ser Val His Ser Lys Leu Ser Glu Ala Ile 
                245                 250                 255     


Lys Gly Leu Pro Leu Lys Gly Glu Gln His Ser His Ser Leu Ala Lys 
            260                 265                 270         


Leu Ser Pro Thr Gly Pro Gly Gly Asp Lys Gly Gln Ser Pro Ile Pro 
        275                 280                 285             


Met Trp Ile Cys Cys Arg Leu Arg Ala Ser Asn Cys Arg Asn Thr Ser 
    290                 295                 300                 


Ala Ala Trp Arg Leu Lys Leu Lys Arg Ser Ser Thr Cys 
305                 310                 315         


<210> 8965
<211> 53
<212> PRT
<213> Homo sapiens

<400> 8965
Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His 
1               5                   10                  15      


Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile 
            20                  25                  30          


Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His 
        35                  40                  45              


Gly Ser Asn Gly Ala 
    50              


<210> 8966
<211> 400
<212> PRT
<213> Homo sapiens

<400> 8966
Ala Trp Leu Gln Ser Ala Gly Glu Leu Pro Ser Asp Gly Gly Cys Ser 
1               5                   10                  15      


Arg Leu Arg Trp Gln Ala His Leu Glu Phe Thr His Asn His Asp Val 
            20                  25                  30          


Gly Asp Leu Thr Trp Asp Lys Ile Ala Val Ser Leu Pro Arg Ser Glu 
        35                  40                  45              


Lys Leu Arg Ser Leu Val Leu Ala Gly Ile Pro His Gly Met Arg Pro 
    50                  55                  60                  


Gln Leu Trp Met Arg Leu Ser Gly Ala Leu Gln Lys Lys Arg Asn Ser 
65                  70                  75                  80  


Glu Leu Ser Tyr Arg Glu Ile Val Lys Asn Ser Ser Asn Asp Glu Thr 
                85                  90                  95      


Ile Ala Ala Lys Gln Ile Glu Lys Asp Leu Leu Arg Thr Met Pro Ser 
            100                 105                 110         


Asn Ala Cys Phe Ala Ser Met Gly Ser Ile Gly Val Pro Arg Leu Arg 
        115                 120                 125             


Arg Val Leu Arg Ala Leu Ala Trp Leu Tyr Pro Glu Ile Gly Tyr Cys 
    130                 135                 140                 


Gln Gly Thr Gly Met Val Ala Ala Cys Leu Leu Leu Phe Leu Glu Glu 
145                 150                 155                 160 


Glu Asp Ala Phe Trp Met Met Ser Ala Ile Ile Glu Asp Leu Leu Pro 
                165                 170                 175     


Ala Ser Tyr Phe Ser Thr Thr Leu Leu Gly Val Gln Thr Asp Gln Arg 
            180                 185                 190         


Val Leu Arg His Leu Ile Val Gln Tyr Leu Pro Arg Leu Asp Lys Leu 
        195                 200                 205             


Leu Gln Glu His Asp Ile Glu Leu Ser Leu Ile Thr Leu His Trp Phe 
    210                 215                 220                 


Leu Thr Ala Phe Ala Ser Val Val Asp Ile Lys Leu Leu Leu Arg Ile 
225                 230                 235                 240 


Trp Asp Leu Phe Phe Tyr Glu Gly Ser Arg Val Leu Phe Gln Leu Thr 
                245                 250                 255     


Leu Gly Met Leu His Leu Lys Glu Glu Glu Leu Ile Gln Ser Glu Asn 
            260                 265                 270         


Ser Ala Ser Ile Phe Asn Thr Leu Ser Asp Ile Pro Ser Gln Met Glu 
        275                 280                 285             


Asp Ala Glu Leu Leu Leu Gly Val Ala Met Arg Leu Ala Gly Ser Leu 
    290                 295                 300                 


Thr Asp Val Ala Val Glu Thr Gln Arg Arg Lys His Leu Ala Tyr Leu 
305                 310                 315                 320 


Ile Ala Asp Gln Gly Gln Leu Leu Gly Ala Gly Thr Leu Thr Asn Leu 
                325                 330                 335     


Ser Gln Val Ala Gln Asp Gly Gly Pro His Leu Asp Pro Gln His Thr 
            340                 345                 350         


Gly Arg Arg Gly His Leu Glu Val Gln Ser Ala Gly Ala Ala Glu Asn 
        355                 360                 365             


Lys Pro Ala Leu Pro Ala Leu Pro Pro Ser Leu Ala Gln Ser Asp His 
    370                 375                 380                 


Ser Cys Gly Val Ile Gln Ala Ser Ser Gly Phe Val His Leu Arg Phe 
385                 390                 395                 400 


<210> 8967
<211> 97
<212> PRT
<213> Homo sapiens

<400> 8967
Met Leu Arg Gly Thr Lys Glu Met Asp Asn Met Ser Pro Arg Leu Arg 
1               5                   10                  15      


Ala Phe Leu Ser Glu Pro Ile Gly Glu Lys Asp Val Cys Trp Val Asp 
            20                  25                  30          


Gly Ile Ser His Glu Leu Ala Ile Asn Leu Val Thr Lys Gly Ile Asn 
        35                  40                  45              


Lys Ala Tyr Ile Leu Leu Gly Gln Phe Leu Leu Met His Lys Asn Glu 
    50                  55                  60                  


Ala Glu Phe Gln Arg Trp Leu Ile Cys Cys Phe Gly Ala Thr Glu Cys 
65                  70                  75                  80  


Glu Ala Gln Gln Thr Ser His Cys Leu Lys Glu Trp Cys Ala Cys Phe 
                85                  90                  95      


Leu 
    


<210> 8968
<211> 336
<212> PRT
<213> Homo sapiens

<400> 8968
Met Glu Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly 
1               5                   10                  15      


Pro Leu Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys 
            20                  25                  30          


Gly Leu Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys 
        35                  40                  45              


Ala Ala Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu Ala Asp 
    50                  55                  60                  


Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr 
65                  70                  75                  80  


Phe Val Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser 
                85                  90                  95      


Ala Tyr Asp Phe Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile 
            100                 105                 110         


Glu Leu Ala Lys Gly Glu Pro Pro Asn Ser Asp Leu His Pro Met Arg 
        115                 120                 125             


Val Leu Phe Leu Ile Pro Lys Asn Ser Pro Pro Thr Leu Glu Gly Gln 
    130                 135                 140                 


His Ser Lys Pro Phe Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Asp 
145                 150                 155                 160 


Pro Arg Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile 
                165                 170                 175     


Thr Arg Tyr Thr Lys Lys Thr Ser Phe Leu Thr Glu Leu Ile Asp Arg 
            180                 185                 190         


Tyr Lys Arg Trp Lys Ser Glu Gly His Gly Glu Glu Ser Ser Ser Glu 
        195                 200                 205             


Asp Ser Asp Ile Asp Gly Glu Ala Glu Asp Gly Glu Gln Gly Pro Ile 
    210                 215                 220                 


Trp Thr Phe Pro Pro Thr Ile Arg Pro Ser Pro His Ser Lys Leu His 
225                 230                 235                 240 


Lys Gly Thr Ala Leu His Ser Ser Gln Lys Pro Ala Glu Pro Val Lys 
                245                 250                 255     


Arg Gln Pro Arg Ser Gln Cys Leu Ser Thr Leu Val Arg Pro Val Phe 
            260                 265                 270         


Gly Glu Val Phe Ser Gln Leu Lys Glu Lys His Lys Gln Ser Gly Gly 
        275                 280                 285             


Ser Val Gly Ala Leu Glu Glu Leu Glu Asn Ala Phe Ser Leu Ala Glu 
    290                 295                 300                 


Glu Ser Cys Pro Gly Ile Ser Asp Lys Leu Met Val His Leu Val Glu 
305                 310                 315                 320 


Arg Val Gln Arg Phe Ser His Asn Arg Asn His Leu Thr Ser Thr Arg 
                325                 330                 335     


<210> 8969
<211> 484
<212> PRT
<213> Homo sapiens

<400> 8969
Met Val His Glu Thr Ser Tyr Ser Ala Gln Phe Lys Gly Glu Ala Ser 
1               5                   10                  15      


Lys Pro Thr Thr Ala Asp Asn Lys Val Ile Asp Arg Arg Arg Ile Arg 
            20                  25                  30          


Ser Leu Tyr Ser Glu Pro Phe Lys Glu Pro Pro Lys Val Glu Lys Pro 
        35                  40                  45              


Ser Val Gln Ser Ser Lys Pro Lys Lys Thr Ser Ala Ser His Lys Pro 
    50                  55                  60                  


Thr Arg Lys Ala Lys Asp Lys Gln Ala Val Ser Gly Gln Ala Ala Lys 
65                  70                  75                  80  


Lys Lys Ser Ala Glu Gly Pro Ser Thr Thr Lys Pro Asp Asp Lys Glu 
                85                  90                  95      


Gln Ser Lys Glu Met Asn Asn Lys Leu Ala Glu Ala Lys Glu Ser Leu 
            100                 105                 110         


Ala Gln Pro Val Ser Asp Ser Ser Lys Thr Gln Gly Pro Val Ala Thr 
        115                 120                 125             


Glu Pro Asp Lys Asp Gln Gly Ser Val Val Pro Gly Leu Leu Lys Gly 
    130                 135                 140                 


Gln Gly Pro Met Val Gln Glu Pro Leu Lys Lys Gln Gly Ser Val Val 
145                 150                 155                 160 


Pro Gly Pro Pro Lys Asp Leu Gly Pro Met Ile Pro Leu Pro Val Lys 
                165                 170                 175     


Asp Gln Asp His Thr Val Pro Glu Pro Leu Lys Asn Glu Ser Pro Val 
            180                 185                 190         


Ile Ser Ala Pro Val Lys Asp Gln Gly Pro Ser Val Pro Val Pro Pro 
        195                 200                 205             


Lys Asn Gln Ser Pro Met Val Pro Ala Lys Val Lys Asp Gln Gly Ser 
    210                 215                 220                 


Val Val Pro Glu Ser Leu Lys Asp Gln Gly Pro Arg Ile Pro Glu Pro 
225                 230                 235                 240 


Val Lys Asn Gln Ala Pro Met Val Pro Ala Pro Val Lys Asp Glu Gly 
                245                 250                 255     


Pro Met Val Ser Ala Ser Val Lys Asp Gln Gly Pro Met Val Ser Ala 
            260                 265                 270         


Pro Val Lys Asp Gln Gly Pro Ile Val Pro Ala Pro Val Lys Gly Glu 
        275                 280                 285             


Gly Pro Ile Val Pro Ala Pro Val Lys Asp Glu Gly Pro Met Val Ser 
    290                 295                 300                 


Ala Pro Ile Lys Asp Gln Asp Pro Met Val Pro Glu His Pro Lys Asp 
305                 310                 315                 320 


Glu Ser Ala Met Ala Thr Ala Pro Ile Lys Asn Gln Gly Ser Met Val 
                325                 330                 335     


Ser Glu Pro Val Lys Asn Gln Gly Leu Val Val Ser Gly Pro Val Lys 
            340                 345                 350         


Asp Gln Asp Val Val Val Pro Glu His Ala Lys Val His Asp Ser Ala 
        355                 360                 365             


Val Val Ala Pro Val Lys Asn Gln Gly Pro Val Val Pro Glu Ser Val 
    370                 375                 380                 


Lys Asn Gln Asp Pro Ile Leu Pro Val Leu Val Lys Asp Gln Gly Pro 
385                 390                 395                 400 


Thr Val Leu Gln Pro Pro Lys Asn Gln Gly Arg Ile Val Pro Glu Pro 
                405                 410                 415     


Leu Lys Asn Gln Val Pro Ile Val Pro Val Pro Leu Lys Asp Gln Asp 
            420                 425                 430         


Pro Leu Val Pro Val Pro Ala Lys Asp Gln Gly Pro Ala Val Pro Glu 
        435                 440                 445             


Pro Leu Lys Thr Gln Gly Pro Arg Asp Pro Gln Leu Pro Thr Val Ser 
    450                 455                 460                 


Pro Leu Pro Arg Val Met Ile Pro Thr Ala Pro His Thr Glu Tyr Ile 
465                 470                 475                 480 


Glu Ser Ser Pro 
                


<210> 8970
<211> 700
<212> PRT
<213> Homo sapiens

<400> 8970
Met Ala Leu Gly Glu Glu Lys Ala Glu Ala Glu Ala Ser Glu Asp Thr 
1               5                   10                  15      


Lys Ala Gln Ser Tyr Gly Arg Gly Ser Cys Arg Glu Gln Pro Pro Arg 
            20                  25                  30          


Leu Glu Ala Glu Gly Gly Leu Ile Ser Pro Val Trp Gly Ala Glu Gly 
        35                  40                  45              


Ile Pro Ala Pro Thr Cys Trp Ile Gly Thr Asp Pro Gly Gly Pro Ser 
    50                  55                  60                  


Arg Ala His Gln Pro Gln Ala Ser Asp Ala Asn Arg Glu Pro Val Ala 
65                  70                  75                  80  


Glu Arg Ser Glu Pro Ala Leu Ser Gly Leu Pro Pro Ala Thr Met Gly 
                85                  90                  95      


Ser Gly Asp Leu Leu Leu Ser Gly Glu Ser Gln Val Glu Lys Thr Lys 
            100                 105                 110         


Leu Ser Ser Ser Glu Glu Phe Pro Gln Thr Leu Ser Leu Pro Arg Thr 
        115                 120                 125             


Thr Thr Ile Cys Ser Gly His Asp Ala Asp Thr Glu Asp Asp Pro Ser 
    130                 135                 140                 


Leu Ala Asp Leu Pro Gln Ala Leu Asp Leu Ser Gln Gln Pro His Ser 
145                 150                 155                 160 


Ser Gly Leu Ser Cys Leu Ser Gln Trp Lys Ser Val Leu Ser Pro Gly 
                165                 170                 175     


Ser Ala Ala Gln Pro Ser Ser Cys Ser Ile Ser Ala Ser Ser Thr Gly 
            180                 185                 190         


Ser Ser Leu Gln Gly His Gln Glu Arg Ala Glu Pro Arg Gly Gly Ser 
        195                 200                 205             


Leu Ala Lys Val Ser Ser Ser Leu Glu Pro Val Val Pro Gln Glu Pro 
    210                 215                 220                 


Ser Ser Val Val Gly Leu Gly Pro Arg Pro Gln Trp Ser Pro Gln Pro 
225                 230                 235                 240 


Val Phe Ser Gly Gly Asp Ala Ser Gly Leu Gly Arg Arg Arg Leu Ser 
                245                 250                 255     


Phe Gln Ala Glu Tyr Trp Ala Cys Val Leu Pro Asp Ser Leu Pro Pro 
            260                 265                 270         


Ser Pro Asp Arg His Ser Pro Leu Trp Asn Pro Asn Lys Glu Tyr Glu 
        275                 280                 285             


Asp Leu Leu Asp Tyr Thr Tyr Pro Leu Arg Pro Gly Pro Gln Leu Pro 
    290                 295                 300                 


Lys His Leu Asp Ser Arg Val Pro Ala Asp Pro Val Leu Gln Asp Ser 
305                 310                 315                 320 


Gly Val Asp Leu Asp Ser Phe Ser Val Ser Pro Ala Ser Thr Leu Lys 
                325                 330                 335     


Ser Pro Thr Asn Val Ser Pro Asn Cys Pro Pro Ala Glu Ala Thr Ala 
            340                 345                 350         


Leu Pro Phe Ser Gly Pro Arg Glu Pro Ser Leu Lys Gln Trp Pro Ser 
        355                 360                 365             


Arg Val Pro Gln Lys Gln Gly Gly Met Gly Leu Ala Ser Trp Ser Gln 
    370                 375                 380                 


Leu Ala Ser Thr Pro Arg Ala Pro Gly Ser Arg Asp Ala Arg Trp Glu 
385                 390                 395                 400 


Arg Arg Glu Pro Ala Leu Arg Gly Ala Lys Asp Arg Leu Thr Ile Gly 
                405                 410                 415     


Lys His Leu Asp Met Gly Ser Pro Gln Leu Arg Thr Arg Asp Arg Gly 
            420                 425                 430         


Trp Pro Ser Pro Arg Pro Glu Arg Glu Lys Arg Thr Ser Gln Ser Ala 
        435                 440                 445             


Arg Arg Pro Thr Cys Thr Glu Ser Arg Trp Lys Ser Glu Glu Glu Val 
    450                 455                 460                 


Glu Ser Asp Asp Glu Tyr Leu Ala Leu Pro Ala Arg Leu Thr Gln Val 
465                 470                 475                 480 


Ser Ser Leu Val Ser Tyr Leu Gly Ser Ile Ser Thr Leu Val Thr Leu 
                485                 490                 495     


Pro Thr Gly Asp Ile Lys Gly Gln Ser Pro Leu Glu Val Ser Asp Ser 
            500                 505                 510         


Asp Gly Pro Ala Ser Phe Pro Ser Ser Ser Ser Gln Ser Gln Leu Pro 
        515                 520                 525             


Pro Gly Ala Ala Leu Gln Gly Ser Gly Asp Pro Glu Gly Gln Asn Pro 
    530                 535                 540                 


Cys Phe Leu Arg Ser Phe Val Arg Ala His Asp Ser Ala Gly Glu Gly 
545                 550                 555                 560 


Ser Leu Gly Ser Ser Gln Ala Leu Gly Val Ser Ser Gly Leu Leu Lys 
                565                 570                 575     


Thr Arg Pro Ser Leu Pro Ala Arg Leu Asp Arg Trp Pro Phe Ser Asp 
            580                 585                 590         


Pro Asp Val Glu Gly Gln Leu Pro Arg Lys Gly Gly Glu Gln Gly Lys 
        595                 600                 605             


Glu Ser Leu Val Gln Cys Val Lys Thr Phe Cys Cys Gln Leu Glu Glu 
    610                 615                 620                 


Leu Ile Cys Trp Leu Tyr Asn Val Ala Asp Val Thr Asp His Gly Thr 
625                 630                 635                 640 


Ala Ala Arg Ser Asn Leu Thr Ser Leu Lys Ser Ser Leu Gln Leu Tyr 
                645                 650                 655     


Arg Val Ile Cys Gly Pro Gly Ser Gly Leu Phe Pro His Lys Ser Val 
            660                 665                 670         


Ala Lys Leu Leu Asp Tyr Lys Val Lys Ser Gln Ile Thr Asn Val Trp 
        675                 680                 685             


Tyr Val Ile Ala Gln Leu Thr Ile Ile Pro Glu Ile 
    690                 695                 700 


<210> 8971
<211> 541
<212> PRT
<213> Homo sapiens

<400> 8971
Met Lys Ser Tyr Val Ser Glu Thr Met Ala Ser Pro Gly Lys Asp Asn 
1               5                   10                  15      


Tyr Arg Met Lys Ser Tyr Lys Asn Asn Ala Leu Asn Pro Glu Glu Met 
            20                  25                  30          


Arg Arg Arg Arg Glu Glu Glu Gly Ile Gln Leu Arg Lys Gln Lys Arg 
        35                  40                  45              


Glu Gln Gln Leu Phe Lys Arg Arg Asn Val Glu Leu Ile Asn Glu Glu 
    50                  55                  60                  


Ala Ala Met Phe Asp Ser Leu Leu Met Asp Ser Tyr Val Ser Ser Thr 
65                  70                  75                  80  


Thr Gly Glu Ser Val Ile Thr Arg Glu Met Val Glu Met Leu Phe Ser 
                85                  90                  95      


Asp Asp Ser Asp Leu Gln Leu Ala Thr Thr Gln Lys Phe Arg Lys Leu 
            100                 105                 110         


Leu Ser Lys Glu Pro Ser Pro Pro Ile Asp Glu Val Ile Asn Thr Pro 
        115                 120                 125             


Arg Val Val Asp Arg Phe Val Glu Phe Leu Lys Arg Asn Glu Asn Cys 
    130                 135                 140                 


Thr Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser Gly 
145                 150                 155                 160 


Thr Ser Gln Gln Thr Lys Ile Val Ile Glu Ala Gly Ala Val Pro Ile 
                165                 170                 175     


Phe Ile Glu Leu Leu Asn Ser Asp Phe Glu Asp Val Gln Glu Gln Ala 
            180                 185                 190         


Val Trp Ala Leu Gly Asn Ile Ala Gly Asp Ser Ser Val Cys Arg Asp 
        195                 200                 205             


Tyr Val Leu Asn Cys Ser Ile Leu Asn Pro Leu Leu Thr Leu Leu Thr 
    210                 215                 220                 


Lys Ser Thr Arg Leu Thr Met Thr Arg Asn Ala Val Trp Ala Leu Ser 
225                 230                 235                 240 


Asn Leu Cys Arg Gly Lys Asn Pro Pro Pro Glu Phe Ala Lys Val Ser 
                245                 250                 255     


Pro Cys Leu Pro Val Leu Ser Arg Leu Leu Phe Ser Ser Asp Ser Asp 
            260                 265                 270         


Leu Leu Ala Asp Ala Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro 
        275                 280                 285             


Asn Glu Lys Ile Gln Ala Val Ile Asp Ser Gly Val Cys Arg Arg Leu 
    290                 295                 300                 


Val Glu Leu Leu Met His Asn Asp Tyr Lys Val Ala Ser Pro Ala Leu 
305                 310                 315                 320 


Arg Ala Val Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val 
                325                 330                 335     


Ile Leu Asn Cys Ser Ala Leu Pro Cys Leu Leu His Leu Leu Ser Ser 
            340                 345                 350         


Pro Lys Glu Ser Ile Arg Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile 
        355                 360                 365             


Thr Ala Gly Asn Arg Ala Gln Ile Gln Ala Val Ile Asp Ala Asn Ile 
    370                 375                 380                 


Phe Pro Val Leu Ile Glu Ile Leu Gln Lys Ala Glu Phe Arg Thr Arg 
385                 390                 395                 400 


Lys Glu Ala Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Thr Pro 
                405                 410                 415     


Glu Gln Ile Arg Tyr Leu Val Ser Leu Gly Cys Ile Lys Pro Leu Cys 
            420                 425                 430         


Asp Leu Leu Thr Val Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn 
        435                 440                 445             


Gly Leu Glu Asn Ile Leu Arg Leu Gly Glu Gln Glu Gly Lys Arg Ser 
    450                 455                 460                 


Gly Ser Gly Val Asn Pro Tyr Cys Gly Leu Ile Glu Glu Ala Tyr Gly 
465                 470                 475                 480 


Leu Asp Lys Ile Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr 
                485                 490                 495     


Gln Lys Ala Phe Asp Leu Ile Glu His Tyr Phe Gly Val Glu Asp Asp 
            500                 505                 510         


Asp Ser Ser Leu Ala Pro Gln Val Asp Glu Thr Gln Gln Gln Phe Ile 
        515                 520                 525             


Phe Gln Gln Pro Glu Ala Pro Met Glu Gly Phe Gln Leu 
    530                 535                 540     


<210> 8972
<211> 571
<212> PRT
<213> Homo sapiens

<400> 8972
Met Leu Asp Cys Gly Met His Met Gly Phe Asn Asp Asp Arg Arg Phe 
1               5                   10                  15      


Pro Asp Phe Ser Tyr Ile Thr Gln Asn Gly Arg Leu Thr Asp Phe Leu 
            20                  25                  30          


Asp Cys Val Ile Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu 
        35                  40                  45              


Pro Tyr Phe Ser Glu Met Val Gly Tyr Asp Gly Pro Ile Tyr Met Thr 
    50                  55                  60                  


His Pro Thr Gln Ala Ile Cys Pro Ile Leu Leu Glu Asp Tyr Arg Lys 
65                  70                  75                  80  


Ile Ala Val Asp Lys Lys Gly Glu Ala Asn Phe Phe Thr Ser Gln Met 
                85                  90                  95      


Ile Lys Asp Cys Met Lys Lys Val Val Ala Val His Leu His Gln Thr 
            100                 105                 110         


Val Gln Val Asp Asp Glu Leu Glu Ile Lys Ala Tyr Tyr Ala Gly His 
        115                 120                 125             


Val Leu Gly Ala Ala Met Phe Gln Ile Lys Val Gly Ser Glu Ser Val 
    130                 135                 140                 


Val Tyr Thr Gly Asp Tyr Asn Met Thr Pro Asp Arg His Leu Gly Ala 
145                 150                 155                 160 


Ala Trp Ile Asp Lys Cys Arg Pro Asn Leu Leu Ile Thr Glu Ser Thr 
                165                 170                 175     


Tyr Ala Thr Thr Ile Arg Asp Ser Lys Arg Cys Arg Glu Arg Asp Phe 
            180                 185                 190         


Leu Lys Lys Val His Glu Thr Val Glu Arg Gly Gly Lys Val Leu Ile 
        195                 200                 205             


Pro Val Phe Ala Leu Gly Arg Ala Gln Glu Leu Cys Ile Leu Leu Glu 
    210                 215                 220                 


Thr Phe Trp Glu Arg Met Asn Leu Lys Val Pro Ile Tyr Phe Ser Thr 
225                 230                 235                 240 


Gly Leu Thr Glu Lys Ala Asn His Tyr Tyr Lys Leu Phe Ile Pro Trp 
                245                 250                 255     


Thr Asn Gln Lys Ile Arg Lys Thr Phe Val Gln Arg Asn Met Phe Glu 
            260                 265                 270         


Phe Lys His Ile Lys Ala Phe Asp Arg Ala Phe Ala Asp Asn Pro Gly 
        275                 280                 285             


Pro Met Val Val Phe Ala Thr Pro Gly Met Leu His Ala Gly Gln Ser 
    290                 295                 300                 


Leu Gln Ile Phe Arg Lys Trp Ala Gly Asn Glu Lys Asn Met Val Ile 
305                 310                 315                 320 


Met Pro Gly Tyr Cys Val Gln Gly Thr Val Gly His Lys Ile Leu Ser 
                325                 330                 335     


Gly Gln Arg Lys Leu Glu Met Glu Gly Arg Gln Val Leu Glu Val Lys 
            340                 345                 350         


Met Gln Val Glu Tyr Met Ser Phe Ser Ala His Ala Asp Ala Lys Gly 
        355                 360                 365             


Ile Met Gln Leu Val Gly Gln Ala Glu Pro Glu Ser Val Leu Leu Val 
    370                 375                 380                 


His Gly Glu Ala Lys Lys Met Glu Phe Leu Lys Gln Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Leu Arg Val Asn Cys Tyr Met Pro Ala Asn Gly Glu Thr Val Thr 
                405                 410                 415     


Leu Pro Thr Ser Pro Ser Ile Pro Val Gly Ile Ser Leu Gly Leu Leu 
            420                 425                 430         


Lys Arg Glu Met Ala Gln Gly Leu Leu Pro Glu Ala Lys Lys Pro Arg 
        435                 440                 445             


Leu Leu His Gly Thr Leu Ile Met Lys Asp Ser Asn Phe Arg Leu Val 
    450                 455                 460                 


Ser Ser Glu Gln Ala Leu Lys Glu Leu Gly Leu Ala Glu His Gln Leu 
465                 470                 475                 480 


Arg Phe Thr Cys Arg Val His Leu His Asp Thr Arg Lys Glu Gln Glu 
                485                 490                 495     


Thr Ala Leu Arg Val Tyr Ser His Leu Lys Ser Val Leu Lys Asp His 
            500                 505                 510         


Cys Val Gln His Leu Pro Asp Gly Ser Val Thr Val Glu Ser Val Leu 
        515                 520                 525             


Leu Gln Ala Ala Ala Pro Ser Glu Asp Pro Gly Thr Lys Val Leu Leu 
    530                 535                 540                 


Val Ser Trp Thr Tyr Gln Asp Glu Glu Leu Gly Ser Phe Leu Thr Ser 
545                 550                 555                 560 


Leu Leu Lys Lys Gly Leu Pro Gln Ala Pro Ser 
                565                 570     


<210> 8973
<211> 743
<212> PRT
<213> Homo sapiens

<400> 8973
Met Glu Ala Ala Ala Val Thr Val Thr Arg Ser Ala Thr Arg Arg Arg 
1               5                   10                  15      


Arg Arg Gln Leu Gln Gly Leu Ala Ala Pro Glu Ala Gly Thr Gln Glu 
            20                  25                  30          


Glu Gln Glu Asp Gln Glu Pro Arg Pro Arg Arg Arg Arg Pro Gly Arg 
        35                  40                  45              


Ser Ile Lys Asp Glu Glu Glu Glu Thr Val Phe Arg Glu Val Val Ser 
    50                  55                  60                  


Phe Ser Pro Asp Pro Leu Pro Val Arg Tyr Tyr Asp Lys Asp Thr Thr 
65                  70                  75                  80  


Lys Pro Ile Ser Phe Tyr Leu Ser Ser Leu Glu Glu Leu Leu Ala Trp 
                85                  90                  95      


Lys Pro Arg Leu Glu Asp Gly Phe Asn Val Ala Leu Glu Pro Leu Ala 
            100                 105                 110         


Cys Arg Gln Pro Pro Leu Ser Ser Gln Arg Pro Arg Thr Leu Leu Cys 
        115                 120                 125             


His Asp Met Met Gly Gly Tyr Leu Asp Asp Arg Phe Ile Gln Gly Ser 
    130                 135                 140                 


Val Val Gln Thr Pro Tyr Ala Phe Tyr His Trp Gln Cys Ile Asp Val 
145                 150                 155                 160 


Phe Val Tyr Phe Ser His His Thr Val Thr Ile Pro Pro Val Gly Trp 
                165                 170                 175     


Thr Asn Thr Ala His Arg His Gly Val Cys Val Leu Gly Thr Phe Ile 
            180                 185                 190         


Thr Glu Trp Asn Glu Gly Gly Arg Leu Cys Glu Ala Phe Leu Ala Gly 
        195                 200                 205             


Asp Glu Arg Ser Tyr Gln Ala Val Ala Asp Arg Leu Val Gln Ile Thr 
    210                 215                 220                 


Gln Phe Phe Arg Phe Asp Gly Trp Leu Ile Asn Ile Glu Asn Ser Leu 
225                 230                 235                 240 


Ser Leu Ala Ala Val Gly Asn Met Pro Pro Phe Leu Arg Tyr Leu Thr 
                245                 250                 255     


Thr Gln Leu His Arg Gln Val Pro Gly Gly Leu Val Leu Trp Tyr Asp 
            260                 265                 270         


Ser Val Val Gln Ser Gly Gln Leu Lys Trp Gln Asp Glu Leu Asn Gln 
        275                 280                 285             


His Asn Arg Val Phe Phe Asp Ser Cys Asp Gly Phe Phe Thr Asn Tyr 
    290                 295                 300                 


Asn Trp Arg Glu Glu His Leu Glu Arg Met Leu Gly Gln Ala Gly Glu 
305                 310                 315                 320 


Arg Arg Ala Asp Val Tyr Val Gly Val Asp Val Phe Ala Arg Gly Asn 
                325                 330                 335     


Val Val Gly Gly Arg Phe Asp Thr Asp Lys Ser Leu Glu Leu Ile Arg 
            340                 345                 350         


Lys His Gly Phe Ser Val Ala Leu Phe Ala Pro Gly Trp Val Tyr Glu 
        355                 360                 365             


Cys Leu Glu Lys Lys Asp Phe Phe Gln Asn Gln Asp Lys Phe Trp Gly 
    370                 375                 380                 


Arg Leu Glu Arg Tyr Leu Pro Thr His Ser Ile Cys Ser Leu Pro Phe 
385                 390                 395                 400 


Val Thr Ser Phe Cys Leu Gly Met Gly Ala Arg Arg Val Cys Tyr Gly 
                405                 410                 415     


Gln Glu Glu Ala Val Gly Pro Trp Tyr His Leu Ser Ala Gln Glu Ile 
            420                 425                 430         


Gln Pro Leu Phe Gly Glu His Arg Leu Gly Gly Asp Gly Arg Gly Trp 
        435                 440                 445             


Val Arg Thr His Cys Cys Leu Glu Asp Ala Trp His Gly Gly Ser Ser 
    450                 455                 460                 


Leu Leu Val Arg Gly Val Ile Pro Pro Glu Val Gly Asn Val Ala Val 
465                 470                 475                 480 


Arg Leu Phe Ser Leu Gln Ala Pro Val Pro Pro Lys Ile Tyr Leu Ser 
                485                 490                 495     


Met Val Tyr Lys Leu Glu Gly Pro Thr Asp Val Thr Val Ala Leu Glu 
            500                 505                 510         


Leu Thr Thr Gly Asp Ala Gly Ser Cys His Ile Gly Gly Ile Ser Val 
        515                 520                 525             


Leu Asn Ala Glu Thr Ser Ser Arg His Ser Leu Arg Pro Leu Arg Val 
    530                 535                 540                 


Pro Pro Thr Lys Leu Ala Arg Trp Val Gly Arg Cys Gly Arg Gln Leu 
545                 550                 555                 560 


Ser Gly Gly Trp Val Gln His Cys Tyr Glu Val Ser Leu Arg Gly Cys 
                565                 570                 575     


Leu Leu Leu Asp Leu Leu Val Cys Phe Ser Arg Pro Pro Gly Ser Arg 
            580                 585                 590         


Glu Glu Glu Ser Phe Thr Cys Arg Leu Gly Glu Ile Gln Val Val Asp 
        595                 600                 605             


Ala Ala Ser Leu Leu Ala Pro Leu Pro Gln Val Gln Ala Val Thr Ile 
    610                 615                 620                 


Ser His Ile Arg Trp Gln Pro Ser Ala Ser Glu Arg Glu Gly Pro Pro 
625                 630                 635                 640 


Ala Leu Leu Gln Leu Ser Cys Thr Leu His Trp Ser Phe Leu Leu Ser 
                645                 650                 655     


Gln Val Arg Cys Phe Arg Ile His Cys Trp Gly Gly Met Ser Asp Asp 
            660                 665                 670         


Ser Pro Gly Arg Glu Leu Pro Arg Pro Glu Met Pro Met Phe Leu Gly 
        675                 680                 685             


Leu Ala Phe Ala Thr Gln Tyr Arg Ile Val Asp Leu Leu Val Glu Ala 
    690                 695                 700                 


Ala Gly Pro Gly Gln Asp Arg Arg Met Glu Phe Leu Val Glu Pro Val 
705                 710                 715                 720 


Pro Lys Glu Gly Phe Arg Val Pro Gln Ala Glu Trp Gly Arg Ala Val 
                725                 730                 735     


Leu Leu Tyr Ser Ala Pro Ala 
            740             


<210> 8974
<211> 131
<212> PRT
<213> Homo sapiens

<400> 8974
Met Glu Leu Arg Val His Met Val Ser His Thr Gly Glu Met Pro Tyr 
1               5                   10                  15      


Lys Val Arg Leu Gly Leu Ser Pro Gly Pro Gly Leu Gly Gly Pro Arg 
            20                  25                  30          


Ile Leu Pro Ala Glu Pro Phe Thr Trp Gly Ala Val Arg His Leu Pro 
        35                  40                  45              


His Ser Ser Cys Gln Gly Ala Cys Leu Pro Cys Leu Pro Cys Leu Ser 
    50                  55                  60                  


Ser Ala Pro Leu Ser Arg Gln Gly Leu Ser Ala Ala Ser Pro Pro Arg 
65                  70                  75                  80  


Ser Leu Leu Gly Pro Cys Phe Phe Pro Trp Arg Thr Gly Leu Ala Ser 
                85                  90                  95      


Ser Gly Gln Leu Ser Pro Glu Ala Leu Leu Cys Thr Ile Leu His Thr 
            100                 105                 110         


Arg Ser Gly Val Leu Pro Glu Ser Ser His Arg Gly Leu Pro Leu Val 
        115                 120                 125             


Pro Ala Leu 
    130     


<210> 8975
<211> 302
<212> PRT
<213> Homo sapiens

<400> 8975
Met Glu His Gly Ile Val Lys Asp Trp Asn Asp Met Glu Arg Ile Trp 
1               5                   10                  15      


Gln Tyr Val Tyr Ser Lys Asp Gln Leu Gln Thr Phe Ser Glu Glu His 
            20                  25                  30          


Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro Arg Lys Asn Arg Glu 
        35                  40                  45              


Arg Ala Ala Glu Val Phe Phe Glu Thr Phe Asn Val Pro Ala Leu Phe 
    50                  55                  60                  


Ile Ser Met Gln Ala Val Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr 
65                  70                  75                  80  


Gly Val Val Leu Asp Ser Gly Asp Gly Val Thr His Ala Val Pro Ile 
                85                  90                  95      


Tyr Glu Gly Phe Ala Met Pro His Ser Ile Met Arg Ile Asp Ile Ala 
            100                 105                 110         


Gly Arg Asp Val Ser Arg Phe Leu Arg Leu Tyr Leu Arg Lys Glu Gly 
        115                 120                 125             


Tyr Asp Phe His Ser Ser Ser Glu Phe Glu Ile Val Lys Ala Ile Lys 
    130                 135                 140                 


Glu Arg Ala Cys Tyr Leu Ser Ile Asn Pro Gln Lys Asp Glu Thr Leu 
145                 150                 155                 160 


Glu Thr Glu Lys Ala Gln Tyr Tyr Leu Pro Asp Gly Ser Thr Ile Glu 
                165                 170                 175     


Ile Gly Pro Ser Arg Phe Arg Ala Pro Glu Leu Leu Phe Arg Pro Asp 
            180                 185                 190         


Leu Ile Gly Glu Glu Ser Glu Gly Ile His Glu Val Leu Val Phe Ala 
        195                 200                 205             


Ile Gln Lys Ser Asp Met Asp Leu Arg Arg Thr Leu Phe Ser Asn Ile 
    210                 215                 220                 


Val Leu Ser Gly Gly Ser Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu 
225                 230                 235                 240 


Leu Ser Glu Val Lys Lys Leu Ala Pro Lys Asp Val Lys Ile Arg Ile 
                245                 250                 255     


Ser Ala Pro Gln Glu Arg Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile 
            260                 265                 270         


Leu Ala Ser Leu Asp Thr Phe Lys Lys Met Trp Val Ser Lys Lys Glu 
        275                 280                 285             


Tyr Glu Glu Asp Gly Ala Arg Ser Ile His Arg Lys Thr Phe 
    290                 295                 300         


<210> 8976
<211> 259
<212> PRT
<213> Homo sapiens

<400> 8976
Met Leu Arg Cys Gly Gln Met Met Leu Ala Gln Ala Leu Ile Cys Arg 
1               5                   10                  15      


His Leu Gly Arg Asp Trp Ser Trp Glu Lys Gln Lys Glu Gln Pro Lys 
            20                  25                  30          


Glu Tyr Gln Arg Ile Leu Gln Cys Phe Leu Asp Arg Lys Asp Cys Cys 
        35                  40                  45              


Tyr Ser Ile His Gln Met Ala Gln Met Gly Val Gly Glu Gly Lys Ser 
    50                  55                  60                  


Ile Gly Glu Trp Phe Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys 
65                  70                  75                  80  


Leu Ala Leu Phe Asp Glu Trp Asn Ser Leu Ala Val Tyr Val Ser Met 
                85                  90                  95      


Asp Asn Thr Val Val Ile Glu Asp Ile Lys Lys Met Cys Arg Val Leu 
            100                 105                 110         


Pro Leu Ser Ala Asp Thr Ala Gly Asp Arg Pro Pro Asp Ser Leu Thr 
        115                 120                 125             


Ala Ser Asn Gln Ser Asp Glu Leu Ile Phe Leu Asp Pro His Thr Thr 
    130                 135                 140                 


Gln Thr Phe Val Asp Thr Glu Glu Asn Gly Thr Val Asn Asp Gln Thr 
145                 150                 155                 160 


Phe His Cys Leu Gln Ser Pro Gln Arg Met Asn Ile Leu Asn Leu Asp 
                165                 170                 175     


Pro Ser Val Ala Leu Gly Phe Phe Cys Lys Glu Glu Lys Asp Phe Asp 
            180                 185                 190         


Asn Trp Cys Ser Leu Val Gln Lys Glu Ile Leu Lys Glu Asn Leu Arg 
        195                 200                 205             


Met Phe Glu Leu Val Gln Lys His Pro Ser His Trp Pro Pro Phe Val 
    210                 215                 220                 


Pro Pro Ala Lys Pro Glu Val Thr Thr Thr Gly Ala Glu Phe Ile Asp 
225                 230                 235                 240 


Ser Thr Glu Gln Leu Glu Glu Phe Asp Leu Glu Glu Asp Phe Glu Ile 
                245                 250                 255     


Leu Ser Val 
            


<210> 8977
<211> 318
<212> PRT
<213> Homo sapiens

<400> 8977
Met Arg Ala Gln Ser Asp Glu Leu Glu Lys Ile Glu Lys His Gly Arg 
1               5                   10                  15      


Ser Ser Lys Asp Lys Glu Asn Ala Lys Ser Leu Asp Lys Pro Glu Gln 
            20                  25                  30          


Phe Leu Tyr Glu Leu Ser Leu Ile Pro Asn Phe Ser Glu Arg Val Phe 
        35                  40                  45              


Cys Ile Leu Phe Gln Ser Thr Phe Ser Glu Ser Ile Cys Ser Ile Arg 
    50                  55                  60                  


Arg Lys Leu Glu Leu Leu Gln Lys Leu Cys Glu Thr Leu Lys Asn Gly 
65                  70                  75                  80  


Pro Gly Val Met Gln Val Leu Gly Leu Val Leu Ala Phe Gly Asn Tyr 
                85                  90                  95      


Met Asn Gly Gly Asn Lys Thr Arg Gly Gln Ala Asp Gly Phe Gly Leu 
            100                 105                 110         


Asp Ile Leu Pro Lys Leu Lys Asp Val Lys Ser Ser Asp Asn Ser Arg 
        115                 120                 125             


Ser Leu Leu Ser Tyr Ile Val Ser Tyr Tyr Leu Arg Asn Phe Asp Glu 
    130                 135                 140                 


Asp Ala Gly Lys Glu Gln Cys Leu Phe Pro Leu Pro Glu Pro Gln Asp 
145                 150                 155                 160 


Leu Phe Gln Ala Ser Gln Met Lys Phe Glu Asp Phe Gln Lys Asp Leu 
                165                 170                 175     


Arg Lys Leu Lys Lys Asp Leu Lys Ala Cys Glu Val Glu Ala Gly Lys 
            180                 185                 190         


Val Tyr Gln Val Ser Ser Lys Glu His Met Gln Pro Phe Lys Glu Asn 
        195                 200                 205             


Met Glu Gln Phe Ile Ile Gln Ala Lys Ile Asp Gln Glu Ala Glu Glu 
    210                 215                 220                 


Asn Ser Leu Thr Glu Thr His Lys Cys Phe Leu Glu Thr Thr Ala Tyr 
225                 230                 235                 240 


Phe Phe Met Lys Pro Lys Leu Gly Glu Lys Glu Val Ser Pro Asn Ala 
                245                 250                 255     


Phe Phe Ser Ile Trp His Glu Phe Ser Ser Asp Phe Lys Asp Phe Trp 
            260                 265                 270         


Lys Lys Glu Asn Lys Leu Leu Leu Gln Glu Arg Val Lys Glu Ala Glu 
        275                 280                 285             


Glu Val Cys Arg Gln Lys Lys Gly Lys Ser Leu Tyr Lys Ile Lys Pro 
    290                 295                 300                 


Arg His Asp Ser Gly Ile Lys Ala Lys Ile Ser Met Lys Thr 
305                 310                 315             


<210> 8978
<211> 114
<212> PRT
<213> Homo sapiens

<400> 8978
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Thr Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Thr His Gly Thr Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Thr Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu 
        


<210> 8979
<211> 454
<212> PRT
<213> Homo sapiens

<400> 8979
Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
            20                  25                  30          


Lys Gly Thr Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
    50                  55                  60                  


Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
65                  70                  75                  80  


Asp Ile Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         


Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
        115                 120                 125             


Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile 
145                 150                 155                 160 


Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
    210                 215                 220                 


Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
            260                 265                 270         


Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser 
        275                 280                 285             


Gly Arg Lys Pro Glu Arg Arg Arg Leu Lys Thr Thr Arg Leu Lys Glu 
    290                 295                 300                 


Tyr Thr Ile Lys Ser His Ser Ser Leu Pro Pro Asn Asn Ser Tyr Ala 
305                 310                 315                 320 


Asp Phe Glu Arg Phe Ser Lys Val Leu Glu Glu Ala Ala Ala Ala Glu 
                325                 330                 335     


Glu Gly Leu Arg Glu Leu Gln Arg Ser Arg Arg Leu Cys His Glu Asp 
            340                 345                 350         


Val Glu Ala Leu Ala Ala Ile Tyr Glu Glu Lys Glu Ala Trp Tyr Arg 
        355                 360                 365             


Glu Glu Ser Asp Ser Leu Gly Gln Asp Leu Arg Arg Leu Arg Gln Glu 
    370                 375                 380                 


Leu Leu Lys Thr Glu Ala Leu Lys Arg Gln Ala Gln Glu Glu Ala Lys 
385                 390                 395                 400 


Gly Ala Leu Leu Gly Thr Ser Gly Leu Lys Arg Arg Phe Ser Arg Leu 
                405                 410                 415     


Glu Asn Arg Tyr Glu Ala Leu Ala Lys Gln Val Ala Ser Glu Met Arg 
            420                 425                 430         


Phe Val Gln Asp Leu Val Arg Ala Leu Glu Gln Glu Lys Leu Gln Gly 
        435                 440                 445             


Val Glu Cys Gly Leu Arg 
    450                 


<210> 8980
<211> 348
<212> PRT
<213> Homo sapiens

<400> 8980
Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
1               5                   10                  15      


Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly Leu Tyr 
    50                  55                  60                  


Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
            100                 105                 110         


Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
        115                 120                 125             


Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
    130                 135                 140                 


Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu Pro Leu 
145                 150                 155                 160 


Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu Leu Arg 
                165                 170                 175     


Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met Lys Ile 
            180                 185                 190         


Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr Glu Asp 
        195                 200                 205             


Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly Thr Lys 
    210                 215                 220                 


Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile Pro Ala 
225                 230                 235                 240 


Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe Arg Arg 
                245                 250                 255     


Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys Glu Ala 
            260                 265                 270         


Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg Val Ile 
        275                 280                 285             


Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys Arg Leu 
    290                 295                 300                 


Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg Gly Asp 
305                 310                 315                 320 


Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr Pro Gln 
                325                 330                 335     


Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
            340                 345             


<210> 8981
<211> 720
<212> PRT
<213> Homo sapiens

<400> 8981
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln Val 
    210                 215                 220                 


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
225                 230                 235                 240 


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
                245                 250                 255     


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
            260                 265                 270         


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
        275                 280                 285             


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
    290                 295                 300                 


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
305                 310                 315                 320 


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
                325                 330                 335     


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
            340                 345                 350         


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
        355                 360                 365             


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
    370                 375                 380                 


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
385                 390                 395                 400 


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
                405                 410                 415     


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
            420                 425                 430         


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
        435                 440                 445             


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
    450                 455                 460                 


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
465                 470                 475                 480 


Glu Leu Glu Ser Leu Thr Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
                485                 490                 495     


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
            500                 505                 510         


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
        515                 520                 525             


Ser Gln Gln Leu Gln Asp Ser Leu Arg Lys Lys Asp Asp Arg Ile Glu 
    530                 535                 540                 


Glu Leu Glu Glu Ala Leu Arg Glu Ser Val Gln Ile Thr Ala Glu Arg 
545                 550                 555                 560 


Glu Met Val Leu Ala Gln Glu Glu Ser Ala Arg Thr Asn Ala Glu Lys 
                565                 570                 575     


Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val Lys Gln Glu Leu 
            580                 585                 590         


Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln Ser Leu Ala Glu 
        595                 600                 605             


Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg Arg Lys His Leu 
    610                 615                 620                 


Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser 
625                 630                 635                 640 


Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser Ser Ser Lys Lys 
                645                 650                 655     


Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu Lys Asp Arg Leu 
            660                 665                 670         


Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala 
        675                 680                 685             


Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His Ser Asn Gln Thr 
    690                 695                 700                 


Asn His Lys Pro Ser Pro Asp Gln Asp Glu Glu Glu Gly Ile Trp Ala 
705                 710                 715                 720 


<210> 8982
<211> 255
<212> PRT
<213> Homo sapiens

<400> 8982
Met Ala Ala Ser Thr Met Ser Val Cys Ser Ser Ala Cys Ser Asp Ser 
1               5                   10                  15      


Trp Gln Val Asp Ala Cys Pro Glu Ser Cys Cys Glu Pro His Cys Cys 
            20                  25                  30          


Ala Leu Ser Cys Cys Ala Pro Ala Pro Cys Leu Thr Leu Val Cys Thr 
        35                  40                  45              


Pro Val Ser Arg Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro 
    50                  55                  60                  


Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys 
65                  70                  75                  80  


Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln 
                85                  90                  95      


Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Leu Pro 
            100                 105                 110         


Thr Cys Ser Lys Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln 
        115                 120                 125             


Pro Thr Cys Cys Ala Ser Ser Ser Ser Gln Gln Ser Cys Cys Val Pro 
    130                 135                 140                 


Val Cys Cys Lys Pro Val Cys Tyr Val Pro Thr Cys Ser Glu Asp Ser 
145                 150                 155                 160 


Ser Ser Cys Cys Gln Gln Ser Ser Cys His Pro Ala Cys Cys Thr Ser 
                165                 170                 175     


Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Arg Cys Lys Pro Val 
            180                 185                 190         


Cys Cys Lys Pro Ile Cys Cys Val Pro Val Cys Ser Gly Ala Ser Thr 
        195                 200                 205             


Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Thr Ser 
    210                 215                 220                 


Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Val Cys 
225                 230                 235                 240 


Arg Pro Ala Cys Cys Ser Leu Cys Ser Gly Gln Glu Ser Ser Cys 
                245                 250                 255 


<210> 8983
<211> 853
<212> PRT
<213> Homo sapiens

<400> 8983
Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met 
            20                  25                  30          


Asp Thr Ser Thr Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp 
        35                  40                  45              


Leu Glu Lys Ser Thr Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly 
    50                  55                  60                  


Glu Ser Phe Gly Gly Glu Thr Ser Asn Ser Gly Asp Pro His Lys Gly 
65                  70                  75                  80  


Phe Ser Val Asp Tyr Tyr Asn Thr Thr Thr Lys Gly Thr Pro Glu Arg 
                85                  90                  95      


Leu His Phe Glu Met Thr His Lys Glu Ile Pro Cys Gln Gly Pro Arg 
            100                 105                 110         


Ala Gln Leu Gly Asn Gly Ser Ser Val Asp Glu Val Ser Phe Tyr Ala 
        115                 120                 125             


Asn Arg Leu Thr Asn Leu Val Ile Ala Met Ala Arg Lys Glu Ile Asn 
    130                 135                 140                 


Glu Lys Ile Asp Gly Ser Glu Asn Lys Cys Val Tyr Gln Ser Leu Tyr 
145                 150                 155                 160 


Met Gly Asn Glu Pro Thr Pro Thr Lys Ser Leu Ser Lys Ile Ala Ser 
                165                 170                 175     


Glu Leu Val Asn Glu Thr Val Ser Ala Cys Ser Arg Asn Ala Ala Pro 
            180                 185                 190         


Asp Lys Ala Pro Gly Ser Gly Asp Arg Val Ser Gly Ser Ser Gln Ser 
        195                 200                 205             


Pro Pro Asn Leu Lys Tyr Lys Ser Thr Leu Lys Ile Lys Glu Ser Thr 
    210                 215                 220                 


Lys Glu Arg Gln Gly Pro Asp Asp Lys Pro Pro Ser Lys Lys Ser Phe 
225                 230                 235                 240 


Phe Tyr Lys Glu Val Phe Glu Ser Arg Asn Gly Asp Tyr Ala Arg Glu 
                245                 250                 255     


Gly Gly Arg Phe Phe Pro Arg Glu Arg Lys Arg Phe Arg Gly Gln Glu 
            260                 265                 270         


Arg Pro Asp Asp Phe Thr Ala Ser Val Ser Glu Gly Ile Met Thr Tyr 
        275                 280                 285             


Ala Asn Ser Val Val Ser Asp Met Met Val Ser Ile Met Lys Thr Leu 
    290                 295                 300                 


Lys Ile Gln Val Lys Asp Thr Thr Ile Ala Thr Ile Leu Leu Lys Lys 
305                 310                 315                 320 


Val Leu Leu Lys His Ala Lys Glu Val Val Ser Asp Leu Ile Asp Ser 
                325                 330                 335     


Phe Leu Arg Asn Leu His Ser Val Thr Gly Thr Leu Met Thr Asp Thr 
            340                 345                 350         


Gln Phe Val Ser Ala Val Lys Arg Thr Val Phe Ser His Gly Ser Gln 
        355                 360                 365             


Lys Ala Thr Asp Ile Met Asp Ala Met Leu Arg Lys Leu Tyr Asn Val 
    370                 375                 380                 


Met Phe Ala Lys Lys Val Pro Glu His Val Arg Lys Ala Gln Asp Lys 
385                 390                 395                 400 


Ala Glu Ser Tyr Ser Leu Ile Ser Met Lys Gly Met Gly Asp Pro Lys 
                405                 410                 415     


Asn Arg Asn Val Asn Phe Ala Met Lys Ser Glu Thr Lys Leu Arg Glu 
            420                 425                 430         


Lys Met Tyr Ser Glu Pro Lys Ser Glu Glu Glu Thr Cys Ala Lys Thr 
        435                 440                 445             


Leu Gly Glu His Ile Ile Lys Glu Gly Leu Thr Leu Trp His Lys Thr 
    450                 455                 460                 


Gln Gln Lys Glu Cys Lys Ser Leu Gly Phe Gln His Ala Ala Phe Glu 
465                 470                 475                 480 


Ala Pro Asn Thr Gln Arg Lys Pro Ala Ser Asp Ile Ser Phe Glu Tyr 
                485                 490                 495     


Pro Glu Asp Ile Gly Asn Leu Ser Leu Pro Pro Tyr Pro Pro Glu Lys 
            500                 505                 510         


Pro Glu Asn Phe Met Tyr Asp Ser Asp Ser Trp Ala Glu Asp Leu Ile 
        515                 520                 525             


Val Ser Ala Leu Leu Leu Ile Gln Tyr His Leu Ala Gln Gly Gly Arg 
    530                 535                 540                 


Arg Asp Ala Arg Ser Phe Val Glu Ala Ala Gly Thr Thr Asn Phe Pro 
545                 550                 555                 560 


Ala Asn Glu Pro Pro Val Ala Pro Asp Glu Ser Cys Leu Lys Ser Ala 
                565                 570                 575     


Pro Ile Val Gly Asp Gln Glu Gln Ala Glu Lys Lys Asp Leu Arg Ser 
            580                 585                 590         


Val Phe Phe Asn Phe Ile Arg Asn Leu Leu Ser Glu Thr Ile Phe Lys 
        595                 600                 605             


Arg Asp Gln Ser Pro Glu Pro Lys Val Pro Glu Gln Pro Val Lys Glu 
    610                 615                 620                 


Asp Arg Lys Leu Cys Glu Arg Pro Leu Ala Ser Ser Pro Pro Arg Leu 
625                 630                 635                 640 


Tyr Glu Asp Asp Glu Thr Pro Gly Ala Leu Ser Gly Leu Thr Lys Met 
                645                 650                 655     


Ala Val Ser Gln Ile Asp Gly His Met Ser Gly Gln Met Val Glu His 
            660                 665                 670         


Leu Met Asn Ser Val Met Lys Leu Cys Val Ile Ile Ala Lys Ser Cys 
        675                 680                 685             


Asp Ala Ser Leu Ala Glu Leu Gly Asp Asp Lys Ser Gly Asp Ala Ser 
    690                 695                 700                 


Arg Leu Thr Ser Ala Phe Pro Asp Ser Leu Tyr Glu Cys Leu Pro Ala 
705                 710                 715                 720 


Lys Gly Thr Gly Ser Ala Glu Ala Val Leu Gln Asn Ala Tyr Gln Ala 
                725                 730                 735     


Ile His Asn Glu Met Arg Gly Thr Ser Gly Gln Pro Pro Glu Gly Cys 
            740                 745                 750         


Ala Ala Pro Thr Val Ile Val Ser Asn His Asn Leu Thr Asp Thr Val 
        755                 760                 765             


Gln Asn Lys Gln Leu Gln Ala Val Leu Gln Trp Val Ala Ala Ser Glu 
    770                 775                 780                 


Leu Asn Val Pro Ile Leu Tyr Phe Ala Gly Asp Asp Glu Gly Ile Gln 
785                 790                 795                 800 


Glu Lys Leu Leu Gln Leu Ser Ala Ala Ala Val Asp Lys Gly Cys Ser 
                805                 810                 815     


Val Gly Glu Val Leu Gln Ser Val Leu Arg Tyr Glu Lys Glu Arg Gln 
            820                 825                 830         


Leu Asn Glu Ala Val Gly Asn Val Thr Pro Leu Gln Leu Leu Asp Trp 
        835                 840                 845             


Leu Met Val Asn Leu 
    850             


<210> 8984
<211> 420
<212> PRT
<213> Homo sapiens

<400> 8984
Met Val His Gly Arg Lys Ala Asn Ala Gln Val Met Glu Ser Glu Glu 
1               5                   10                  15      


Phe Met Leu Leu Pro Ala Asn Gln Leu Ile Asp Ile Ile Ser Ser Asp 
            20                  25                  30          


Glu Leu Asn Val Arg Ser Glu Glu Gln Val Phe Asn Ala Val Met Ala 
        35                  40                  45              


Trp Val Lys Tyr Ser Ile Gln Glu Arg Arg Pro Gln Leu Pro Gln Val 
    50                  55                  60                  


Leu Gln His Val Arg Leu Pro Leu Leu Ser Pro Lys Phe Leu Val Gly 
65                  70                  75                  80  


Thr Val Gly Ser Asp Pro Leu Ile Lys Ser Asp Glu Glu Cys Arg Asp 
                85                  90                  95      


Leu Val Asp Glu Ala Lys Asn Tyr Leu Leu Leu Pro Gln Glu Arg Pro 
            100                 105                 110         


Leu Met Gln Gly Pro Arg Thr Arg Pro Arg Lys Pro Ile Arg Cys Gly 
        115                 120                 125             


Glu Val Leu Phe Ala Val Gly Gly Trp Cys Ser Gly Asp Ala Ile Ser 
    130                 135                 140                 


Ser Val Glu Arg Tyr Asp Pro Gln Thr Asn Glu Trp Arg Met Val Ala 
145                 150                 155                 160 


Ser Met Ser Lys Arg Arg Cys Gly Val Gly Val Ser Val Leu Asp Asp 
                165                 170                 175     


Leu Leu Tyr Ala Val Gly Gly His Asp Gly Ser Ser Tyr Leu Asn Ser 
            180                 185                 190         


Val Glu Arg Tyr Asp Pro Lys Thr Asn Gln Trp Ser Ser Asp Val Ala 
        195                 200                 205             


Pro Thr Ser Thr Cys Arg Thr Ser Val Gly Val Ala Val Leu Gly Gly 
    210                 215                 220                 


Phe Leu Tyr Ala Val Gly Gly Gln Asp Gly Val Ser Cys Leu Asn Ile 
225                 230                 235                 240 


Val Glu Arg Tyr Asp Pro Lys Glu Asn Lys Trp Thr Arg Val Ala Ser 
                245                 250                 255     


Met Ser Thr Arg Arg Leu Gly Val Ala Val Ala Val Leu Gly Gly Phe 
            260                 265                 270         


Leu Tyr Ala Val Gly Gly Ser Asp Gly Thr Ser Pro Leu Asn Thr Val 
        275                 280                 285             


Glu Arg Tyr Asn Pro Gln Glu Asn Arg Trp His Thr Ile Ala Pro Met 
    290                 295                 300                 


Gly Thr Arg Arg Lys His Leu Gly Cys Ala Val Tyr Gln Asp Met Ile 
305                 310                 315                 320 


Tyr Ala Val Gly Gly Arg Asp Asp Thr Thr Glu Leu Ser Ser Ala Glu 
                325                 330                 335     


Arg Tyr Asn Pro Arg Thr Asn Gln Trp Ser Pro Val Val Ala Met Thr 
            340                 345                 350         


Ser Arg Arg Ser Gly Val Gly Leu Ala Val Val Asn Gly Gln Leu Met 
        355                 360                 365             


Ala Val Gly Gly Phe Asp Gly Thr Thr Tyr Leu Lys Thr Ile Glu Val 
    370                 375                 380                 


Phe Asp Pro Asp Ala Asn Thr Trp Arg Leu Tyr Gly Gly Met Asn Tyr 
385                 390                 395                 400 


Arg Arg Leu Gly Gly Gly Val Gly Val Ile Lys Met Thr His Cys Glu 
                405                 410                 415     


Ser His Ile Trp 
            420 


<210> 8985
<211> 172
<212> PRT
<213> Homo sapiens

<400> 8985
Met Ser Cys Thr Ile Glu Lys Ala Leu Ala Asp Ala Lys Ala Leu Val 
1               5                   10                  15      


Glu Arg Leu Arg Asp His Asp Asp Ala Ala Glu Ser Leu Ile Glu Gln 
            20                  25                  30          


Thr Thr Ala Leu Asn Lys Arg Val Glu Ala Met Lys Gln Tyr Gln Glu 
        35                  40                  45              


Glu Ile Gln Glu Leu Asn Glu Val Ala Arg His Arg Pro Arg Ser Thr 
    50                  55                  60                  


Leu Val Met Gly Ile Gln Gln Glu Asn Arg Gln Ile Arg Glu Leu Gln 
65                  70                  75                  80  


Gln Glu Asn Lys Glu Leu Arg Thr Ser Leu Glu Glu His Gln Ser Ala 
                85                  90                  95      


Leu Glu Leu Ile Met Ser Lys Tyr Arg Glu Gln Met Phe Arg Leu Leu 
            100                 105                 110         


Met Ala Ser Lys Lys Asp Asp Pro Gly Ile Ile Met Lys Leu Lys Glu 
        115                 120                 125             


Gln His Ser Lys Ile Asp Met Val His Arg Asn Lys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Asp Ala Ser Arg His Ile Leu Glu Ala Pro Gln His Gly Leu 
145                 150                 155                 160 


Glu Arg Arg His Leu Glu Ala Asn Gln Asn Val His 
                165                 170         


<210> 8986
<211> 270
<212> PRT
<213> Homo sapiens

<400> 8986
Met Leu Phe Ile Phe Pro Leu Ser Leu Pro Trp Arg Pro Ser Cys Trp 
1               5                   10                  15      


Lys Glu Ser Cys Ser Thr Gly Gln Arg Gln Ala Gly Arg Ser Arg Glu 
            20                  25                  30          


Asp Ser Val Thr Pro Pro Pro Ser Ser Pro Trp Pro Thr Pro Pro Ala 
        35                  40                  45              


Gly Ala Met Ser Thr Lys Gln Glu Ala Arg Arg Asp Glu Gly Glu Ala 
    50                  55                  60                  


Arg Thr Arg Gly Gln Glu Ala Gln Leu Arg Asp Arg Ala His Leu Ser 
65                  70                  75                  80  


Leu His Lys Asp Ser Ala Asp Leu Leu Pro Leu Asp Ser Leu Lys Arg 
                85                  90                  95      


Leu Gly Thr Ser Lys Asp Leu Gln Pro Arg Ser Val Ile Gln Arg Arg 
            100                 105                 110         


Leu Val Glu Gly Asn Pro Asn Trp Leu Gln Gly Glu Pro Pro Arg Met 
        115                 120                 125             


Gln Asp Leu Ile His Gly Gln Glu Ser Arg Arg Lys Thr Ser Arg Thr 
    130                 135                 140                 


Glu Ile Pro Ala Leu Leu Val Asn Cys Lys Cys Gln Asp Gln Leu Leu 
145                 150                 155                 160 


Arg Val Ala Val Asp Thr Gly Thr Gln Tyr Asn Arg Ile Ser Ala Gly 
                165                 170                 175     


Cys Leu Ser Arg Leu Gly Leu Glu Lys Arg Val Leu Lys Ala Ser Ala 
            180                 185                 190         


Gly Asp Leu Ala Pro Gly Pro Pro Thr Gln Val Glu Gln Leu Glu Leu 
        195                 200                 205             


Gln Leu Gly Gln Glu Thr Val Val Cys Ser Ala Gln Val Val Asp Ala 
    210                 215                 220                 


Glu Ser Pro Glu Phe Cys Leu Gly Leu Gln Thr Leu Leu Ser Leu Lys 
225                 230                 235                 240 


Cys Cys Ile Asp Leu Glu His Gly Val Leu Arg Leu Lys Ala Pro Phe 
                245                 250                 255     


Ser Glu Leu Pro Phe Leu Pro Leu Tyr Gln Glu Pro Gly Gln 
            260                 265                 270 


<210> 8987
<211> 80
<212> PRT
<213> Homo sapiens

<400> 8987
Thr Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys His Pro 
1               5                   10                  15      


Val Cys Ser Cys Ser Pro Ala Cys Gln Pro Thr Cys Cys Ile His Ser 
            20                  25                  30          


Pro Cys Gln Ala Ser Cys Tyr Val Pro Val Ser Cys Gln Pro Ile Ile 
        35                  40                  45              


Tyr Val Thr Pro Ser Cys Gln Ser Ser Gly Cys Cys Gln Pro Pro Cys 
    50                  55                  60                  


Thr Thr Ala Leu Cys Arg Pro Ile Ser Cys Ser Thr Pro Ser Cys Cys 
65                  70                  75                  80  


<210> 8988
<211> 670
<212> PRT
<213> Homo sapiens

<400> 8988
Met Ala Leu Gly Glu Glu Lys Ala Glu Ala Glu Ala Ser Glu Asp Thr 
1               5                   10                  15      


Lys Ala Gln Ser Tyr Gly Arg Gly Ser Cys Arg Glu Arg Glu Leu Asp 
            20                  25                  30          


Ile Pro Gly Pro Met Ser Gly Glu Gln Pro Pro Arg Leu Glu Ala Glu 
        35                  40                  45              


Gly Gly Leu Ile Ser Pro Val Trp Gly Ala Glu Gly Ile Pro Ala Pro 
    50                  55                  60                  


Thr Cys Trp Ile Gly Thr Asp Pro Gly Gly Pro Ser Arg Ala His Gln 
65                  70                  75                  80  


Pro Gln Ala Ser Asp Ala Asn Arg Glu Pro Val Ala Glu Arg Ser Glu 
                85                  90                  95      


Pro Ala Leu Ser Gly Leu Pro Pro Ala Thr Met Gly Ser Gly Asp Leu 
            100                 105                 110         


Leu Leu Ser Gly Glu Ser Gln Val Glu Lys Thr Lys Leu Ser Ser Ser 
        115                 120                 125             


Glu Glu Phe Pro Gln Thr Leu Ser Leu Pro Arg Thr Thr Thr Ile Cys 
    130                 135                 140                 


Ser Gly His Asp Ala Asp Thr Glu Asp Asp Pro Ser Leu Ala Asp Leu 
145                 150                 155                 160 


Pro Gln Ala Leu Asp Leu Ser Gln Gln Pro His Ser Ser Gly Leu Ser 
                165                 170                 175     


Cys Leu Ser Gln Trp Lys Ser Val Leu Ser Pro Gly Ser Ala Ala Gln 
            180                 185                 190         


Pro Ser Ser Cys Ser Ile Ser Ala Ser Ser Thr Gly Ser Ser Leu Gln 
        195                 200                 205             


Gly His Gln Glu Arg Ala Glu Pro Arg Gly Gly Ser Leu Ala Lys Val 
    210                 215                 220                 


Ser Ser Ser Leu Glu Pro Val Val Pro Gln Glu Pro Ser Ser Val Val 
225                 230                 235                 240 


Gly Leu Gly Pro Arg Pro Gln Trp Ser Pro Gln Pro Val Phe Ser Gly 
                245                 250                 255     


Gly Asp Ala Ser Gly Leu Gly Arg Arg Arg Leu Ser Phe Gln Ala Glu 
            260                 265                 270         


Tyr Trp Ala Cys Val Leu Pro Asp Ser Leu Pro Pro Ser Pro Asp Arg 
        275                 280                 285             


His Ser Pro Leu Trp Asn Pro Asn Lys Glu Tyr Glu Asp Leu Leu Asp 
    290                 295                 300                 


Tyr Thr Tyr Pro Leu Arg Pro Gly Pro Gln Leu Pro Lys His Leu Asp 
305                 310                 315                 320 


Ser Arg Val Pro Ala Asp Pro Val Leu Gln Asp Ser Gly Val Asp Leu 
                325                 330                 335     


Asp Ser Phe Ser Val Ser Pro Ala Ser Thr Leu Lys Ser Pro Thr Asn 
            340                 345                 350         


Val Ser Pro Asn Cys Pro Pro Ala Glu Ala Thr Ala Leu Pro Phe Ser 
        355                 360                 365             


Gly Pro Arg Glu Pro Ser Leu Lys Gln Trp Pro Ser Arg Val Pro Gln 
    370                 375                 380                 


Lys Gln Gly Gly Met Gly Leu Ala Ser Trp Ser Gln Leu Ala Ser Thr 
385                 390                 395                 400 


Pro Arg Ala Pro Gly Ser Arg Asp Ala Arg Trp Glu Arg Arg Glu Pro 
                405                 410                 415     


Ala Leu Arg Gly Ala Lys Asp Arg Leu Thr Ile Gly Lys His Leu Asp 
            420                 425                 430         


Met Gly Ser Pro Gln Leu Arg Thr Arg Asp Arg Gly Trp Pro Ser Pro 
        435                 440                 445             


Arg Pro Glu Arg Glu Lys Arg Thr Ser Gln Ser Ala Arg Arg Pro Thr 
    450                 455                 460                 


Cys Thr Glu Ser Arg Trp Lys Ser Glu Glu Glu Val Glu Ser Asp Asp 
465                 470                 475                 480 


Glu Tyr Leu Ala Leu Pro Ala Arg Leu Thr Gln Val Ser Ser Leu Val 
                485                 490                 495     


Ser Tyr Leu Gly Ser Ile Ser Thr Leu Val Thr Leu Pro Thr Gly Asp 
            500                 505                 510         


Ile Lys Gly Gln Ser Pro Leu Glu Val Ser Asp Ser Asp Gly Pro Ala 
        515                 520                 525             


Ser Phe Pro Ser Ser Ser Ser Gln Ser Gln Leu Pro Pro Gly Ala Ala 
    530                 535                 540                 


Leu Gln Gly Ser Gly Asp Pro Glu Gly Gln Asn Pro Cys Phe Leu Arg 
545                 550                 555                 560 


Ser Phe Val Arg Ala His Asp Ser Ala Gly Glu Gly Ser Leu Gly Ser 
                565                 570                 575     


Ser Gln Ala Leu Gly Val Ser Ser Gly Leu Leu Lys Thr Arg Pro Ser 
            580                 585                 590         


Leu Pro Ala Arg Leu Asp Arg Trp Pro Phe Ser Asp Pro Asp Val Glu 
        595                 600                 605             


Gly Gln Leu Pro Arg Lys Gly Gly Glu Gln Gly Lys Glu Ser Leu Val 
    610                 615                 620                 


Gln Cys Val Lys Thr Phe Cys Cys Gln Leu Glu Glu Leu Ile Cys Trp 
625                 630                 635                 640 


Leu Tyr Asn Val Ala Asp Val Thr Asp His Gly Thr Ala Ala Arg Ser 
                645                 650                 655     


Asn Leu Thr Ser Leu Lys Ser Ser Leu Gln Leu Tyr Arg Phe 
            660                 665                 670 


<210> 8989
<211> 233
<212> PRT
<213> Homo sapiens

<400> 8989
Met Lys Gln Leu Ile Glu Asp Thr Glu Lys Asn Lys Val Tyr Val Ala 
1               5                   10                  15      


Met Val Thr Asp Tyr Gly Ala Phe Ile Lys Ile Pro Gly Cys Arg Lys 
            20                  25                  30          


Gln Gly Leu Val His Arg Thr His Met Ser Ser Cys Arg Val Asp Lys 
        35                  40                  45              


Pro Ser Glu Ile Val Asp Val Gly Asp Lys Val Trp Val Lys Leu Ile 
    50                  55                  60                  


Gly Arg Glu Met Lys Asn Asp Arg Ile Lys Val Ser Leu Ser Met Lys 
65                  70                  75                  80  


Val Val Asn Gln Gly Thr Gly Lys Asp Leu Asp Pro Asn Asn Val Ile 
                85                  90                  95      


Ile Glu Gln Glu Glu Arg Arg Arg Arg Ser Phe Gln Asp Tyr Thr Gly 
            100                 105                 110         


Gln Lys Ile Thr Leu Glu Ala Val Leu Asn Thr Thr Cys Lys Lys Cys 
        115                 120                 125             


Gly Cys Lys Gly His Phe Ala Lys Asp Cys Phe Met Gln Pro Gly Gly 
    130                 135                 140                 


Thr Lys Tyr Ser Leu Ile Pro Asp Glu Glu Glu Glu Lys Glu Glu Ala 
145                 150                 155                 160 


Lys Ser Ala Glu Phe Glu Lys Pro Asp Pro Thr Arg Asn Pro Ser Arg 
                165                 170                 175     


Lys Arg Lys Lys Glu Lys Lys Lys Lys Lys His Arg Asp Arg Lys Ser 
            180                 185                 190         


Ser Asp Ser Asp Ser Ser Asp Ser Glu Ser Asp Thr Gly Lys Arg Ala 
        195                 200                 205             


Arg His Thr Ser Lys Asp Ser Lys Ala Ala Lys Lys Lys Lys Lys Lys 
    210                 215                 220                 


Lys Lys His Lys Lys Lys His Lys Glu 
225                 230             


<210> 8990
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8990
Met Gly Trp Arg Leu Leu Thr Gln Asp Glu Gly Pro Ala Leu Val Pro 
1               5                   10                  15      


Gly Gly Arg Leu Gly Asp Leu Trp Asp Tyr His Gln His Arg Tyr Leu 
            20                  25                  30          


Gln Gly Val Pro Glu Gly Val Arg Asp Leu Pro Pro Gly Val Ala Leu 
        35                  40                  45              


Pro Leu Glu Ser Asn Leu Ala Phe Met Asn Gly Val Ser Phe Thr Lys 
    50                  55                  60                  


Gly Cys Tyr Ile Gly Gln Glu Leu Thr Ala Arg Thr His His Met Gly 
65                  70                  75                  80  


Val Ile Arg Lys Arg Leu Phe Pro Val Arg Phe Leu Asp Pro Leu Pro 
                85                  90                  95      


Thr Ser Gly Ile Thr Pro Gly Ala Thr Val Leu Thr Ala Ser Gly Gln 
            100                 105                 110         


Thr Val Gly Lys Phe Arg Ala Gly Gln Gly Asn Val Gly Leu Ala Leu 
        115                 120                 125             


Leu Trp Ser Glu Lys Ile Lys Gly Pro Leu His Ile Arg Ala Ser Glu 
    130                 135                 140                 


Gly Ala Gln Val Ala Leu Ala Ala Ser Val Pro Asp Trp Trp Pro Thr 
145                 150                 155                 160 


Val Ser Lys 
            


<210> 8991
<211> 267
<212> PRT
<213> Homo sapiens

<400> 8991
Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Gly Val 
    130                 135                 140                 


Leu Val Gln Val Ser Pro Ser Leu Val Lys Arg Gln Lys Thr His Phe 
145                 150                 155                 160 


His Asp Leu Pro Cys Gly Ala Ser Val Ile Leu Gly Asn Asn Gly Phe 
                165                 170                 175     


Ile Trp Ile Tyr Pro Thr Pro Glu His Lys Glu Glu Glu Ala Gly Gly 
            180                 185                 190         


Phe Ile Ala Asn Leu Glu Pro Val Ser Leu Ala Asp Arg Glu Val Ile 
        195                 200                 205             


Ser Arg Leu Arg Asn Cys Ile Ile Ser Leu Val Thr Gln Arg Met Met 
    210                 215                 220                 


Leu Tyr Asp Thr Ser Ile Leu Tyr Cys Tyr Glu Ala Ser Leu Pro His 
225                 230                 235                 240 


Gln Ile Lys Asp Ile Leu Lys Pro Glu Ile Met Glu Glu Ile Val Met 
                245                 250                 255     


Glu Thr Arg Gln Arg Leu Leu Glu Gln Glu Gly 
            260                 265         


<210> 8992
<211> 1036
<212> PRT
<213> Homo sapiens

<400> 8992
Met Pro Val Phe Lys Glu Val Lys Val His Leu Leu Glu Asp Ala Gly 
1               5                   10                  15      


Ile Glu Lys Asp Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser Gly 
            20                  25                  30          


Ile Asp Ser Ala Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile Ala 
        35                  40                  45              


Thr Ala Ala Pro Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys Val 
    50                  55                  60                  


Asn Ser Val Thr Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys His 
65                  70                  75                  80  


Leu Gln Arg Val Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln Glu 
                85                  90                  95      


Lys Leu His Cys His Asp His Glu Lys Gln Met Asn Val Phe Met Glu 
            100                 105                 110         


Gln His Ile Arg His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp Ile 
        115                 120                 125             


Gln Thr His Phe Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln Pro 
    130                 135                 140                 


Val Ser Met Pro Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys Pro 
145                 150                 155                 160 


Glu His Pro Asn Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr Phe 
                165                 170                 175     


Ala Ser Lys Gln Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe Asp 
            180                 185                 190         


Lys Gln Lys Ser Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala Pro 
        195                 200                 205             


Val Pro Val Ser Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu Leu 
    210                 215                 220                 


Glu Glu Lys Glu Asn Met Glu Val Ser Cys His Arg Gly Asn Val Arg 
225                 230                 235                 240 


Leu Leu Glu Gln Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys Ser 
                245                 250                 255     


Glu Ser Ser Asn Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp Thr 
            260                 265                 270         


Pro Glu Lys Thr Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr Thr 
        275                 280                 285             


Lys Val Thr Met Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly Gln 
    290                 295                 300                 


Lys Glu Lys Glu Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu Ser 
305                 310                 315                 320 


Met Leu Lys Leu Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln Thr 
                325                 330                 335     


Thr Asn Thr Thr Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu Arg 
            340                 345                 350         


Gly Val Gln Asn Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala Ile 
        355                 360                 365             


Ile Arg Ala Lys Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala Leu 
    370                 375                 380                 


Ser Thr Asn Arg Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr Val 
385                 390                 395                 400 


Asp Glu Trp Ile Lys Thr Ile Ser Ala Glu Ile Gln Asp Glu Leu Ser 
                405                 410                 415     


Arg Thr Asp Tyr Glu Gln Lys Arg Phe Asp Gln Lys Asn Gln Arg Thr 
            420                 425                 430         


Lys Lys Gly Gln Asn Met Thr Lys Asp Ile Arg Thr Asn Thr Gln Asp 
        435                 440                 445             


Lys Thr Val Asn Lys Ser Val Ile Pro Arg Lys His Ser Gln Lys Gln 
    450                 455                 460                 


Ile Glu Glu His Phe Arg Asn Leu Pro Met Arg Gly Met Pro Ala Ser 
465                 470                 475                 480 


Ser Leu Gln Lys Glu Arg Lys Glu Gly Leu Leu Lys Ala Thr Thr Val 
                485                 490                 495     


Ile Gln Asp Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val Tyr 
            500                 505                 510         


Gln Gly His Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe Asn 
        515                 520                 525             


Ser Pro Ser Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu Arg 
    530                 535                 540                 


Val Lys Gly Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe Tyr 
545                 550                 555                 560 


Ala Thr Lys Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val Pro 
                565                 570                 575     


Val Leu Pro His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg Glu 
            580                 585                 590         


Met Pro Thr Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met Ala 
        595                 600                 605             


Ile Leu Leu Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro Ala 
    610                 615                 620                 


Gly Val Ile Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser Ile 
625                 630                 635                 640 


Pro Pro Ser Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn Ile 
                645                 650                 655     


Ala Ile Val Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu Thr 
            660                 665                 670         


Val Gln Val Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser Ser 
        675                 680                 685             


Ala Asp Val Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Leu Pro 
    690                 695                 700                 


Pro Val Gln Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp Glu 
705                 710                 715                 720 


Glu Glu Val Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp Val 
                725                 730                 735     


Ile Gln Glu Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro Ile 
            740                 745                 750         


Leu Glu Phe Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn Gly 
        755                 760                 765             


Pro Pro Phe Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp Ile 
    770                 775                 780                 


Leu Asp Lys Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu Ile 
785                 790                 795                 800 


Gln Trp Val Glu Gln Glu Ile Met Ser Arg Ile Ile Ser Gly Leu Phe 
                805                 810                 815     


Pro Val Gln Gln Gln Ile Ala Pro Ser Ile Ser Val Ser Val Ser Glu 
            820                 825                 830         


Thr Ser Glu Pro Leu Thr Ser Asp Ile Val Glu Gly Thr Ser Ser Gly 
        835                 840                 845             


Ala Leu Gln Leu Phe Val Asp Ala Gly Val Pro Val Asn Ser Asn Val 
    850                 855                 860                 


Ile Lys His Phe Val Asn Glu Ala Leu Ala Glu Thr Ile Ala Val Met 
865                 870                 875                 880 


Leu Gly Asp Arg Glu Ala Lys Lys Gln Gly Pro Val Ala Thr Gly Val 
                885                 890                 895     


Ser Gly Asp Ala Ser Thr Asn Glu Thr Tyr Leu Pro Ala Arg Val Cys 
            900                 905                 910         


Thr Pro Leu Pro Thr Pro Gln Pro Thr Pro Pro Cys Ser Pro Ser Ser 
        915                 920                 925             


Pro Ala Lys Glu Cys Val Leu Val Lys Thr Pro Asp Ser Ser Pro Cys 
    930                 935                 940                 


Asp Ser Asp His Asp Met Ala Phe Pro Val Lys Glu Ile Cys Ala Glu 
945                 950                 955                 960 


Lys Gly Asp Asp Met Pro Ala Ile Met Leu Val Asn Thr Pro Thr Val 
                965                 970                 975     


Thr Pro Thr Thr Thr Pro Pro Pro Ala Ala Ala Val Phe Thr Pro Thr 
            980                 985                 990         


Leu Ser Asp Ile Ser Ile Asp Lys  Leu Lys Val Ser Ser  Pro Glu Leu 
        995                 1000                 1005             


Pro Lys  Pro Trp Gly Asp Gly  Asp Leu Pro Leu Glu  Glu Glu Asn 
    1010                 1015                 1020             


Pro Asn  Ser Pro Gln Glu Glu  Leu His Pro Arg Ala  Met 
    1025                 1030                 1035     


<210> 8993
<211> 1116
<212> PRT
<213> Homo sapiens

<400> 8993
Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Val Glu Gln Leu Lys Glu Glu Leu Ser 
        435                 440                 445             


Ser Lys Glu Ala Gln Trp Glu Glu Leu Lys Lys Lys Ala Ala Gly Leu 
    450                 455                 460                 


Gln Ala Glu Ile Gly Gln Val Lys Gln Glu Leu Ser Arg Lys Asp Thr 
465                 470                 475                 480 


Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu Thr Asn Gln Phe 
                485                 490                 495     


Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu Ser Leu Thr Ala 
            500                 505                 510         


Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val Asp Ala Leu Arg 
        515                 520                 525             


Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys Lys Thr Lys Gln 
    530                 535                 540                 


Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala Gly Glu Ile His 
545                 550                 555                 560 


Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys Val Asn Val Leu 
                565                 570                 575     


Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg Asp Lys Glu Lys 
            580                 585                 590         


Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu Gln Ala Asp Thr 
        595                 600                 605             


Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu Ala Leu Ala Glu 
    610                 615                 620                 


Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg Asp Arg Asp Glu 
625                 630                 635                 640 


Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys Asp Leu Lys Asp 
                645                 650                 655     


Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu Ser Glu Lys Glu 
            660                 665                 670         


Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser Leu Ala Ser Ser 
        675                 680                 685             


Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu Ile Ala Leu Glu 
    690                 695                 700                 


Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln Leu Lys Lys Ala 
705                 710                 715                 720 


His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu Met Ser Asp Arg 
                725                 730                 735     


Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys Asp Glu Ser Ser 
            740                 745                 750         


Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile Leu Lys Glu Val 
        755                 760                 765             


Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala Glu Leu Glu Arg 
    770                 775                 780                 


Gln Val Lys Asp Gln Asn Lys Lys Val Ala Asn Leu Lys His Lys Glu 
785                 790                 795                 800 


Gln Val Glu Lys Lys Lys Ser Ala Gln Met Leu Glu Glu Ala Arg Arg 
                805                 810                 815     


Arg Glu Asp Asn Leu Asn Asp Ser Ser Gln Gln Leu Gln Asp Ser Leu 
            820                 825                 830         


Arg Lys Lys Asp Asp Arg Ile Glu Glu Leu Glu Glu Ala Leu Arg Glu 
        835                 840                 845             


Ser Val Gln Ile Thr Ala Glu Arg Glu Met Val Leu Ala Gln Glu Glu 
    850                 855                 860                 


Ser Ala Arg Thr Asn Ala Glu Lys Gln Val Glu Glu Leu Leu Met Ala 
865                 870                 875                 880 


Met Glu Lys Val Lys Gln Glu Leu Glu Ser Met Lys Ala Lys Leu Ser 
                885                 890                 895     


Ser Thr Gln Gln Ser Leu Ala Glu Lys Glu Thr His Leu Thr Asn Leu 
            900                 905                 910         


Arg Ala Glu Arg Arg Lys His Leu Glu Glu Val Leu Glu Met Lys Gln 
        915                 920                 925             


Glu Ala Leu Leu Ala Ala Ile Ser Glu Lys Asp Ala Asn Ile Ala Leu 
    930                 935                 940                 


Leu Glu Leu Ser Ser Ser Lys Lys Lys Thr Gln Glu Glu Val Ala Ala 
945                 950                 955                 960 


Leu Lys Arg Glu Lys Asp Arg Leu Val Gln Gln Leu Lys Gln Gln Thr 
                965                 970                 975     


Gln Asn Arg Met Lys Leu Met Ala Asp Asn Tyr Glu Asp Asp His Phe 
            980                 985                 990         


Lys Ser Ser His Ser Asn Gln Thr  Asn His Lys Pro Ser  Pro Asp Gln 
        995                 1000                 1005             


Ile Ile  Gln Pro Leu Leu Glu  Leu Asp Gln Asn Arg  Ser Lys Leu 
    1010                 1015                 1020             


Lys Leu  Tyr Ile Gly His Leu  Thr Thr Leu Cys His  Asp Arg Asp 
    1025                 1030                 1035             


Pro Leu  Ile Leu Arg Gly Leu  Thr Pro Pro Ala Ser  Tyr Asn Leu 
    1040                 1045                 1050             


Asp Asp  Asp Gln Ala Ala Trp  Glu Asn Glu Leu Gln  Lys Met Thr 
    1055                 1060                 1065             


Arg Gly  Gln Leu Gln Asp Glu  Leu Glu Lys Gly Glu  Arg Asp Asn 
    1070                 1075                 1080             


Ala Glu  Leu Gln Glu Phe Ala  Asn Ala Ile Leu Gln  Gln Ile Ala 
    1085                 1090                 1095             


Asp His  Cys Pro Asp Ile Leu  Glu Gln Val Val Asn  Ala Leu Glu 
    1100                 1105                 1110             


Glu Ser  Ser 
    1115     


<210> 8994
<211> 271
<212> PRT
<213> Homo sapiens

<400> 8994
Met Arg Gln Leu His Pro Glu Ala Ile Ala Ala Ile Gln Ser Lys Ala 
1               5                   10                  15      


Leu Phe Ser Lys Ala Glu Glu Gln Leu Leu Ser Lys Val Gly Ser Thr 
            20                  25                  30          


Ser Gln Pro Thr Leu Glu Thr Phe Gln Asp Leu Leu His Arg His Pro 
        35                  40                  45              


Asp Ala Phe Tyr Leu Ala Arg Thr Ala Lys Ala Leu Gln Ala His Trp 
    50                  55                  60                  


Gln Leu Met Lys Gln Tyr Tyr Leu Leu Glu Asp Gln Thr Val Gln Pro 
65                  70                  75                  80  


Leu Pro Lys Gly Asp Gln Val Leu Asn Phe Ser Asp Ala Glu Asp Leu 
                85                  90                  95      


Ile Asp Asp Ser Lys Leu Lys Asp Met Arg Asp Glu Val Leu Glu His 
            100                 105                 110         


Glu Leu Met Val Ala Asp Arg Arg Gln Lys Arg Glu Ile Arg Gln Leu 
        115                 120                 125             


Glu Gln Glu Leu His Lys Trp Gln Val Leu Val Asp Ser Ile Thr Gly 
    130                 135                 140                 


Met Ser Ser Pro Asp Phe Asp Asn Gln Thr Leu Ala Val Leu Arg Gly 
145                 150                 155                 160 


Arg Met Val Arg Tyr Leu Met Arg Ser Arg Glu Ile Thr Leu Gly Arg 
                165                 170                 175     


Ala Thr Lys Asp Asn Gln Ile Asp Val Asp Leu Ser Leu Glu Gly Pro 
            180                 185                 190         


Ala Trp Lys Ile Ser Arg Lys Gln Gly Val Ile Lys Leu Lys Asn Asn 
        195                 200                 205             


Gly Asp Phe Phe Ile Ala Asn Glu Gly Arg Arg Pro Ile Tyr Ile Asp 
    210                 215                 220                 


Gly Arg Pro Val Leu Cys Gly Ser Lys Trp Arg Leu Ser Asn Asn Ser 
225                 230                 235                 240 


Val Val Glu Ile Ala Ser Leu Arg Phe Val Phe Leu Ile Asn Gln Asp 
                245                 250                 255     


Leu Ile Ala Leu Ile Arg Ala Glu Ala Ala Lys Ile Thr Pro Gln 
            260                 265                 270     


<210> 8995
<211> 916
<212> PRT
<213> Homo sapiens

<400> 8995
Met Glu Met Pro Leu Pro Pro Asp Asp Gln Glu Leu Arg Asn Val Ile 
1               5                   10                  15      


Asp Lys Leu Ala Gln Phe Val Ala Arg Asn Gly Pro Glu Phe Glu Lys 
            20                  25                  30          


Met Thr Met Glu Lys Gln Lys Asp Asn Pro Lys Phe Ser Phe Leu Phe 
        35                  40                  45              


Gly Gly Glu Phe Tyr Ser Tyr Tyr Lys Cys Lys Leu Ala Leu Glu Gln 
    50                  55                  60                  


Gln Gln Leu Ile Cys Lys Gln Gln Thr Pro Glu Leu Glu Pro Ala Ala 
65                  70                  75                  80  


Thr Met Pro Pro Leu Pro Gln Pro Pro Leu Ala Pro Ala Ala Pro Ile 
                85                  90                  95      


Pro Pro Ala Gln Gly Ala Pro Ser Met Asp Glu Leu Ile Gln Gln Ser 
            100                 105                 110         


Gln Trp Asn Leu Gln Gln Gln Glu Gln His Leu Leu Ala Leu Arg Gln 
        115                 120                 125             


Glu Gln Val Thr Ala Ala Val Ala His Ala Val Glu Gln Gln Met Gln 
    130                 135                 140                 


Lys Leu Leu Glu Glu Thr Gln Leu Asp Met Asn Glu Phe Asp Asn Leu 
145                 150                 155                 160 


Leu Gln Pro Ile Ile Asp Thr Cys Thr Lys Asp Ala Ile Ser Ala Gly 
                165                 170                 175     


Lys Asn Trp Met Phe Ser Asn Ala Lys Ser Pro Pro His Cys Glu Leu 
            180                 185                 190         


Met Ala Gly His Leu Arg Asn Arg Ile Thr Ala Asp Gly Ala His Phe 
        195                 200                 205             


Glu Leu Arg Leu His Leu Ile Tyr Leu Ile Asn Asp Val Leu His His 
    210                 215                 220                 


Cys Gln Arg Lys Gln Ala Arg Glu Leu Leu Ala Ala Leu Gln Lys Val 
225                 230                 235                 240 


Val Val Pro Ile Tyr Cys Thr Ser Phe Leu Ala Val Glu Glu Asp Lys 
                245                 250                 255     


Gln Gln Lys Ile Ala Arg Leu Leu Gln Leu Trp Glu Lys Asn Gly Tyr 
            260                 265                 270         


Phe Asp Asp Ser Ile Ile Gln Gln Leu Gln Ser Pro Ala Leu Gly Leu 
        275                 280                 285             


Gly Gln Tyr Gln Ala Thr Leu Ile Asn Glu Tyr Ser Ser Val Val Gln 
    290                 295                 300                 


Pro Val Gln Leu Ala Phe Gln Gln Gln Ile Gln Thr Leu Lys Thr Gln 
305                 310                 315                 320 


His Glu Glu Phe Val Thr Ser Leu Ala Gln Gln Gln Gln Gln Gln Gln 
                325                 330                 335     


Gln Gln Gln Gln Gln Leu Gln Met Pro Gln Met Glu Ala Glu Val Lys 
            340                 345                 350         


Ala Thr Pro Pro Pro Pro Ala Pro Pro Pro Ala Pro Ala Pro Ala Pro 
        355                 360                 365             


Ala Ile Pro Pro Thr Thr Gln Pro Asp Asp Ser Lys Pro Pro Ile Gln 
    370                 375                 380                 


Met Pro Gly Ser Ser Glu Tyr Glu Ala Pro Gly Gly Val Gln Asp Pro 
385                 390                 395                 400 


Ala Ala Ala Gly Pro Arg Gly Pro Gly Pro His Asp Gln Ile Pro Pro 
                405                 410                 415     


Asn Lys Pro Pro Trp Phe Asp Gln Pro His Pro Val Ala Pro Trp Gly 
            420                 425                 430         


Gln Gln Gln Pro Pro Glu Gln Pro Pro Tyr Pro His His Gln Gly Gly 
        435                 440                 445             


Pro Pro His Cys Pro Pro Trp Asn Asn Ser His Glu Gly Met Trp Gly 
    450                 455                 460                 


Glu Gln Arg Gly Asp Pro Gly Trp Asn Gly Gln Arg Asp Ala Pro Trp 
465                 470                 475                 480 


Asn Asn Gln Pro Asp Ala Ala Trp Asn Ser Gln Phe Glu Gly Pro Trp 
                485                 490                 495     


Asn Ser Gln His Glu Gln Pro Pro Trp Gly Gly Gly Gln Arg Glu Pro 
            500                 505                 510         


Pro Phe Arg Met Gln Arg Pro Pro His Phe Arg Gly Pro Phe Pro Pro 
        515                 520                 525             


His Gln Gln His Pro Gln Phe Asn Gln Pro Pro His Pro His Asn Phe 
    530                 535                 540                 


Asn Arg Phe Pro Pro Arg Phe Met Gln Asp Asp Phe Pro Pro Arg His 
545                 550                 555                 560 


Pro Phe Glu Arg Pro Pro Tyr Pro His Arg Phe Asp Tyr Pro Gln Gly 
                565                 570                 575     


Asp Phe Pro Ala Glu Met Gly Pro Pro His His His Pro Gly His Arg 
            580                 585                 590         


Met Pro His Pro Gly Ile Asn Glu His Pro Pro Trp Ala Gly Pro Gln 
        595                 600                 605             


His Pro Asp Phe Gly Pro Pro Pro His Gly Phe Asn Gly Gln Pro Pro 
    610                 615                 620                 


His Met Arg Arg Gln Gly Pro Pro His Ile Asn His Asp Asp Pro Ser 
625                 630                 635                 640 


Leu Val Pro Asn Val Pro Tyr Phe Asp Leu Pro Ala Gly Leu Met Ala 
                645                 650                 655     


Pro Leu Val Lys Leu Glu Asp His Glu Tyr Lys Pro Leu Asp Pro Lys 
            660                 665                 670         


Asp Ile Arg Leu Pro Pro Pro Met Pro Pro Ser Glu Arg Leu Leu Ala 
        675                 680                 685             


Ala Val Glu Ala Phe Tyr Ser Pro Pro Ser His Asp Arg Pro Arg Asn 
    690                 695                 700                 


Ser Glu Gly Trp Glu Gln Asn Gly Leu Tyr Glu Phe Phe Arg Ala Lys 
705                 710                 715                 720 


Met Arg Ala Arg Arg Arg Lys Gly Gln Glu Lys Arg Asn Ser Gly Pro 
                725                 730                 735     


Ser Arg Ser Arg Ser Arg Ser Lys Ser Arg Gly Arg Ser Ser Ser Arg 
            740                 745                 750         


Ser Asn Ser Arg Ser Ser Lys Ser Ser Gly Ser Tyr Ser Arg Ser Arg 
        755                 760                 765             


Ser Arg Ser Cys Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Ser Arg 
    770                 775                 780                 


Ser Arg Ser Arg Ser Ser Arg Ser Arg Ser Arg Ser Gln Ser Arg Ser 
785                 790                 795                 800 


Arg Ser Lys Ser Tyr Ser Pro Gly Arg Arg Arg Arg Ser Arg Ser Arg 
                805                 810                 815     


Ser Pro Thr Pro Pro Ser Ser Ala Gly Leu Gly Ser Asn Ser Ala Pro 
            820                 825                 830         


Pro Ile Pro Asp Ser Arg Leu Gly Glu Glu Asn Lys Gly His Gln Met 
        835                 840                 845             


Leu Val Lys Met Gly Trp Ser Gly Ser Gly Gly Leu Gly Ala Lys Glu 
    850                 855                 860                 


Gln Gly Ile Gln Asp Pro Ile Lys Gly Gly Asp Val Arg Asp Lys Trp 
865                 870                 875                 880 


Asp Gln Tyr Lys Gly Val Gly Val Ala Leu Asp Asp Pro Tyr Glu Asn 
                885                 890                 895     


Tyr Arg Arg Asn Lys Ser Tyr Ser Phe Ile Ala Arg Met Lys Ala Arg 
            900                 905                 910         


Asp Glu Cys Lys 
        915     


<210> 8996
<211> 320
<212> PRT
<213> Homo sapiens

<400> 8996
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210> 8997
<211> 244
<212> PRT
<213> Homo sapiens

<400> 8997
Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210> 8998
<211> 1374
<212> PRT
<213> Homo sapiens

<400> 8998
Met Thr Ser Ala Ala Glu Ile Lys Lys Pro Pro Val Ala Pro Lys Pro 
1               5                   10                  15      


Lys Phe Val Val Ala Asn Asn Lys Pro Ala Pro Pro Pro Ile Ala Pro 
            20                  25                  30          


Lys Pro Asp Ile Val Ile Ser Ser Val Pro Gln Ser Thr Lys Lys Met 
        35                  40                  45              


Lys Pro Ala Ile Ala Pro Lys Pro Lys Val Leu Lys Thr Ser Pro Val 
    50                  55                  60                  


Arg Glu Ile Gly Gln Ser Pro Ser Arg Lys Ile Met Leu Asn Leu Glu 
65                  70                  75                  80  


Gly His Lys Gln Glu Leu Ala Glu Ser Thr Asp Asn Phe Asn Cys Lys 
                85                  90                  95      


Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser Cys 
            100                 105                 110         


Ser Ser Glu Cys Ile His Lys Leu Gly His Arg Glu Asn Leu Cys Val 
        115                 120                 125             


Lys Gln Leu Val Leu Glu Pro Leu Glu Met Asn Glu Asn Leu Glu Asn 
    130                 135                 140                 


Ser Lys Ile Asp Glu Thr Leu Thr Ile Lys Thr Arg Ser Lys Cys Asp 
145                 150                 155                 160 


Leu Tyr Gly Glu Lys Ala Lys Asn Gln Gly Gly Val Val Leu Lys Ala 
                165                 170                 175     


Ser Val Leu Glu Glu Glu Leu Lys Asp Ala Leu Ile His Gln Met Pro 
            180                 185                 190         


Pro Phe Ile Ser Ala Gln Lys His Arg Pro Thr Asp Ser Pro Glu Met 
        195                 200                 205             


Asn Gly Gly Cys Asn Ser Asn Gly Gln Phe Arg Ile Glu Phe Ala Asp 
    210                 215                 220                 


Leu Ser Pro Ser Pro Ser Ser Phe Glu Lys Val Pro Asp His His Ser 
225                 230                 235                 240 


Cys His Leu Gln Leu Pro Ser Asp Glu Cys Glu His Phe Glu Thr Cys 
                245                 250                 255     


Gln Asp Asp Ser Glu Lys Ser Asn Asn Cys Phe Gln Ser Ser Glu Leu 
            260                 265                 270         


Glu Ala Leu Glu Asn Gly Lys Arg Ser Thr Leu Ile Ser Ser Asp Gly 
        275                 280                 285             


Val Ser Lys Lys Ser Glu Val Lys Asp Leu Gly Pro Leu Glu Ile His 
    290                 295                 300                 


Leu Val Pro Tyr Thr Pro Lys Phe Pro Thr Pro Lys Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Ala Arg Leu Leu Arg Gln Lys Cys Val Asp Thr Pro Ser Glu 
                325                 330                 335     


Ser Thr Glu Glu Pro Gly Asn Ser Asp Ser Ser Ser Ser Cys Leu Thr 
            340                 345                 350         


Glu Asn Ser Leu Lys Ile Asn Lys Ile Ser Val Leu His Gln Asn Val 
        355                 360                 365             


Leu Cys Lys Gln Glu Gln Val Asp Lys Met Lys Leu Gly Asn Lys Ser 
    370                 375                 380                 


Glu Leu Asn Met Glu Ser Asn Ser Asp Ala Gln Asp Leu Val Asn Ser 
385                 390                 395                 400 


Gln Lys Ala Met Cys Asn Glu Thr Thr Ser Phe Glu Lys Met Ala Pro 
                405                 410                 415     


Ser Phe Asp Lys Asp Ser Asn Leu Ser Ser Asp Ser Thr Thr Val Asp 
            420                 425                 430         


Gly Ser Ser Met Ser Leu Ala Val Asp Glu Gly Thr Gly Phe Ile Arg 
        435                 440                 445             


Cys Thr Val Ser Met Ser Leu Pro Lys Gln Leu Lys Leu Thr Cys Asn 
    450                 455                 460                 


Glu His Leu Gln Ser Gly Arg Asn Leu Gly Val Ser Ala Pro Gln Met 
465                 470                 475                 480 


Gln Lys Glu Ser Val Ile Lys Glu Glu Asn Ser Leu Arg Ile Val Pro 
                485                 490                 495     


Lys Lys Pro Gln Arg His Ser Leu Pro Ala Thr Gly Val Leu Lys Lys 
            500                 505                 510         


Ala Ala Ser Glu Glu Leu Leu Glu Lys Ser Ser Tyr Pro Ser Ser Glu 
        515                 520                 525             


Glu Lys Ser Ser Glu Lys Ser Leu Glu Arg Asn His Leu Gln His Leu 
    530                 535                 540                 


Cys Ala Gln Asn Arg Gly Val Ser Ser Ser Phe Asp Met Pro Lys Arg 
545                 550                 555                 560 


Ala Ser Glu Lys Pro Val Trp Lys Leu Pro His Pro Ile Leu Pro Phe 
                565                 570                 575     


Ser Gly Asn Pro Glu Phe Leu Lys Ser Val Thr Val Ser Ser Asn Ser 
            580                 585                 590         


Glu Pro Ser Thr Ala Leu Thr Lys Pro Arg Ala Lys Ser Leu Ser Ala 
        595                 600                 605             


Met Asp Val Glu Lys Cys Thr Lys Pro Cys Lys Asp Ser Thr Lys Lys 
    610                 615                 620                 


Asn Ser Phe Lys Lys Leu Leu Ser Met Lys Leu Ser Ile Cys Phe Met 
625                 630                 635                 640 


Lys Ser Asp Phe Gln Lys Phe Trp Ser Lys Ser Ser Gln Leu Gly Asp 
                645                 650                 655     


Thr Thr Thr Gly His Leu Ser Ser Gly Glu Gln Lys Gly Ile Glu Ser 
            660                 665                 670         


Asp Trp Gln Gly Leu Leu Val Gly Glu Glu Lys Arg Ser Lys Pro Ile 
        675                 680                 685             


Lys Ala Tyr Ser Thr Glu Asn Tyr Ser Leu Glu Ser Gln Lys Lys Arg 
    690                 695                 700                 


Lys Lys Ser Arg Gly Gln Thr Ser Ala Ala Asn Gly Leu Arg Ala Glu 
705                 710                 715                 720 


Ser Leu Asp Asp Gln Met Leu Ser Arg Glu Ser Ser Ser Gln Ala Pro 
                725                 730                 735     


Tyr Lys Ser Val Thr Ser Leu Cys Ala Pro Glu Tyr Glu Asn Ile Arg 
            740                 745                 750         


His Tyr Glu Glu Ile Pro Glu Tyr Glu Asn Leu Pro Phe Ile Met Ala 
        755                 760                 765             


Ile Arg Lys Thr Gln Glu Leu Glu Trp Gln Asn Ser Ser Ser Met Glu 
    770                 775                 780                 


Asp Ala Asp Ala Asn Val Tyr Glu Val Glu Glu Pro Tyr Glu Ala Pro 
785                 790                 795                 800 


Asp Gly Gln Leu Gln Leu Gly Pro Arg His Gln His Ser Ser Ser Gly 
                805                 810                 815     


Ala Ser Gln Glu Glu Gln Asn Asp Leu Gly Leu Gly Asp Leu Pro Ser 
            820                 825                 830         


Asp Glu Glu Glu Ile Ile Asn Ser Ser Asp Glu Asp Asp Val Ser Ser 
        835                 840                 845             


Glu Ser Ser Lys Gly Glu Pro Asp Pro Leu Glu Asp Lys Gln Asp Glu 
    850                 855                 860                 


Asp Asn Gly Met Lys Ser Lys Val His His Ile Ala Lys Glu Ile Met 
865                 870                 875                 880 


Ser Ser Glu Lys Val Phe Val Asp Val Leu Lys Leu Leu His Ile Asp 
                885                 890                 895     


Phe Arg Asp Ala Val Ala His Ala Ser Arg Gln Leu Gly Lys Pro Val 
            900                 905                 910         


Ile Glu Asp Arg Ile Leu Asn Gln Ile Leu Tyr Tyr Leu Pro Gln Leu 
        915                 920                 925             


Tyr Glu Leu Asn Arg Asp Leu Leu Lys Glu Leu Glu Glu Arg Met Leu 
    930                 935                 940                 


His Trp Thr Glu Gln Gln Arg Ile Ala Asp Ile Phe Val Lys Lys Gly 
945                 950                 955                 960 


Pro Tyr Leu Lys Met Tyr Ser Thr Tyr Ile Lys Glu Phe Asp Lys Asn 
                965                 970                 975     


Ile Ala Leu Leu Asp Glu Gln Cys Lys Lys Asn Pro Gly Phe Ala Ala 
            980                 985                 990         


Val Val Arg Glu Phe Glu Met Ser  Pro Arg Cys Ala Asn  Leu Ala Leu 
        995                 1000                 1005             


Lys His  Tyr Leu Leu Lys Pro  Val Gln Arg Ile Pro  Gln Tyr Arg 
    1010                 1015                 1020             


Leu Leu  Leu Thr Asp Tyr Leu  Lys Asn Leu Ile Glu  Asp Ala Gly 
    1025                 1030                 1035             


Asp Tyr  Arg Asp Thr Gln Asp  Ala Leu Ala Val Val  Ile Glu Val 
    1040                 1045                 1050             


Ala Asn  His Ala Asn Asp Thr  Met Lys Gln Gly Asp  Asn Phe Gln 
    1055                 1060                 1065             


Lys Leu  Met Gln Ile Gln Tyr  Ser Leu Asn Gly His  His Glu Ile 
    1070                 1075                 1080             


Val Gln  Pro Gly Arg Val Phe  Leu Lys Glu Gly Ile  Leu Met Lys 
    1085                 1090                 1095             


Leu Ser  Arg Lys Val Met Gln  Pro Arg Met Phe Phe  Leu Phe Asn 
    1100                 1105                 1110             


Asp Ala  Leu Leu Tyr Thr Thr  Pro Val Gln Ser Gly  Met Tyr Lys 
    1115                 1120                 1125             


Leu Asn  Asn Met Leu Ser Leu  Ala Gly Met Lys Val  Arg Lys Pro 
    1130                 1135                 1140             


Thr Gln  Glu Ala Tyr Gln Asn  Glu Leu Lys Ile Glu  Ser Val Glu 
    1145                 1150                 1155             


Arg Ser  Phe Ile Leu Ser Ala  Ser Ser Ala Thr Glu  Arg Asp Glu 
    1160                 1165                 1170             


Trp Leu  Glu Ala Ile Ser Arg  Ala Ile Glu Glu Tyr  Ala Lys Lys 
    1175                 1180                 1185             


Arg Ile  Thr Phe Cys Pro Ser  Arg Ser Leu Asp Glu  Ala Asp Ser 
    1190                 1195                 1200             


Glu Asn  Lys Glu Glu Val Ser  Pro Leu Gly Ser Lys  Ala Pro Ile 
    1205                 1210                 1215             


Trp Ile  Pro Asp Thr Arg Ala  Thr Met Cys Met Ile  Cys Thr Ser 
    1220                 1225                 1230             


Glu Phe  Thr Leu Thr Trp Arg  Arg His His Cys Arg  Ala Cys Gly 
    1235                 1240                 1245             


Lys Ile  Val Cys Gln Ala Cys  Ser Ser Asn Lys Tyr  Gly Leu Asp 
    1250                 1255                 1260             


Tyr Leu  Lys Asn Gln Pro Ala  Arg Val Cys Glu His  Cys Phe Gln 
    1265                 1270                 1275             


Glu Leu  Gln Lys Leu Asp His  Gln His Ser Pro Arg  Ile Gly Ser 
    1280                 1285                 1290             


Pro Gly  Asn His Lys Ser Pro  Ser Ser Ala Leu Ser  Ser Val Leu 
    1295                 1300                 1305             


His Ser  Ile Pro Ser Gly Arg  Lys Gln Lys Lys Ile  Pro Ala Ala 
    1310                 1315                 1320             


Leu Lys  Glu Val Ser Ala Asn  Thr Glu Asp Ser Ser  Met Ser Gly 
    1325                 1330                 1335             


Tyr Leu  Tyr Arg Ser Lys Gly  Asn Lys Lys Pro Trp  Lys His Phe 
    1340                 1345                 1350             


Trp Phe  Val Ile Lys Asn Lys  Val Leu Tyr Thr Tyr  Ala Ala Ser 
    1355                 1360                 1365             


Glu Val  Arg Ser Glu Ile 
    1370                 


<210> 8999
<211> 481
<212> PRT
<213> Homo sapiens

<400> 8999
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Asn Leu Pro Asn His 
    290                 295                 300                 


Leu Val Ile Pro Thr Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 9000
<211> 155
<212> PRT
<213> Homo sapiens

<400> 9000
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp 
145                 150                 155 


<210> 9001
<211> 139
<212> PRT
<213> Homo sapiens

<400> 9001
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly 
    130                 135                 


<210> 9002
<211> 1093
<212> PRT
<213> Homo sapiens

<400> 9002
Met Gly Gly Lys Ala Trp Pro Arg Arg Ala Val Gly Thr Ala Gly Gly 
1               5                   10                  15      


Pro Cys Ala Glu Gln Ile Ser Ala Pro Phe Gln Thr Leu Leu Met Pro 
            20                  25                  30          


His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu Arg His 
        35                  40                  45              


Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser Glu Pro 
    50                  55                  60                  


His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln Lys Arg 
65                  70                  75                  80  


Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly Glu Ser 
                85                  90                  95      


Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu Leu Val 
            100                 105                 110         


Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val Ser Gly 
        115                 120                 125             


Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala Trp Tyr 
    130                 135                 140                 


Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln Ala Arg 
145                 150                 155                 160 


Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro Pro Pro 
                165                 170                 175     


Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val Ala Ile 
            180                 185                 190         


Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln Val Leu 
        195                 200                 205             


Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala Val Val 
    210                 215                 220                 


Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu Leu Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala Lys Gly 
                245                 250                 255     


Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu Asp Trp 
            260                 265                 270         


Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala Val Thr 
        275                 280                 285             


Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg Asn His 
    290                 295                 300                 


Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser Asp Ile 
305                 310                 315                 320 


Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg Leu Pro 
                325                 330                 335     


Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val Ala Phe 
            340                 345                 350         


Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr Thr Arg 
        355                 360                 365             


Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro Asp Asp 
    370                 375                 380                 


Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro Leu Met 
385                 390                 395                 400 


Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro His Val 
                405                 410                 415     


Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala Asp Ala 
            420                 425                 430         


Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile Ala Glu 
        435                 440                 445             


Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly Leu His 
    450                 455                 460                 


Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu Trp Gly 
465                 470                 475                 480 


Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile Cys Ser 
                485                 490                 495     


Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp Phe Val 
            500                 505                 510         


Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu Ser Gly 
        515                 520                 525             


Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln His Trp 
    530                 535                 540                 


Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp Trp Gly 
545                 550                 555                 560 


His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln Gly Glu 
                565                 570                 575     


Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg Glu Val 
            580                 585                 590         


Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu Glu Arg 
        595                 600                 605             


Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe Pro Phe 
    610                 615                 620                 


Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg Phe Tyr 
625                 630                 635                 640 


Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe Trp Val 
                645                 650                 655     


Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu Pro Phe 
            660                 665                 670         


Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly Arg Lys 
        675                 680                 685             


Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile Ile Ser 
    690                 695                 700                 


Gly Val Glu Met Gln Val Leu Gln Glu Lys Leu Arg Ser Gly Asn Leu 
705                 710                 715                 720 


Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys Asp Phe 
                725                 730                 735     


Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Thr Leu 
            740                 745                 750         


Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val Ser Glu 
        755                 760                 765             


Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala Leu Arg 
    770                 775                 780                 


Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro Ala Glu 
785                 790                 795                 800 


Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser Arg Leu 
                805                 810                 815     


Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg Glu Leu 
            820                 825                 830         


Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn Leu Cys 
        835                 840                 845             


Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser Pro Arg 
    850                 855                 860                 


Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu Gly Leu 
865                 870                 875                 880 


Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu Trp Gln 
                885                 890                 895     


Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile Ser Val 
            900                 905                 910         


Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln Pro Glu 
        915                 920                 925             


Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val Leu Arg 
    930                 935                 940                 


Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg Val Leu 
945                 950                 955                 960 


Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala Phe Leu 
                965                 970                 975     


Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu Leu Pro 
            980                 985                 990         


Pro Gly Ala Ala Ala Pro Ser Gly  Trp Ala Gln Ala Pro  Leu Ser Asp 
        995                 1000                 1005             


Thr Ala  Gln Val Tyr Met Glu  Leu Gln Gly Leu Val  Asp Pro Gln 
    1010                 1015                 1020             


Ile Gln  Leu Pro Leu Leu Ala  Ala Arg Arg Tyr Lys  Leu Gln Lys 
    1025                 1030                 1035             


Gln Leu  Asp Ser Leu Thr Ala  Arg Thr Pro Ser Glu  Gly Glu Ala 
    1040                 1045                 1050             


Gly Thr  Gln Arg Gln Gln Lys  Leu Ser Ser Leu Gln  Leu Glu Leu 
    1055                 1060                 1065             


Ser Lys  Leu Asp Lys Ala Ala  Ser His Leu Arg Gln  Leu Met Asp 
    1070                 1075                 1080             


Glu Pro  Pro Ala Pro Gly Ser  Pro Glu Leu 
    1085                 1090             


<210> 9003
<211> 76
<212> PRT
<213> Homo sapiens

<400> 9003
Met Asn Ser Val Gly Glu Ala Cys Thr Asp Met Lys Arg Glu Tyr Asp 
1               5                   10                  15      


Gln Cys Phe Asn Arg Trp Phe Ala Glu Lys Phe Leu Lys Gly Asp Ser 
            20                  25                  30          


Ser Gly Asp Pro Cys Thr Asp Leu Phe Lys Arg Tyr Gln Gln Cys Val 
        35                  40                  45              


Gln Lys Ala Ile Lys Glu Lys Glu Ile Pro Ile Glu Gly Leu Glu Phe 
    50                  55                  60                  


Met Gly His Gly Lys Glu Lys Pro Glu Asn Ser Ser 
65                  70                  75      


<210> 9004
<211> 244
<212> PRT
<213> Homo sapiens

<400> 9004
Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210> 9005
<211> 257
<212> PRT
<213> Homo sapiens

<400> 9005
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Val Phe Tyr His Gly Cys Trp Leu Leu Ser Gly Cys 
                245                 250                 255     


Asp 
    


<210> 9006
<211> 267
<212> PRT
<213> Homo sapiens

<400> 9006
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Ser Tyr Asn 
        195                 200                 205             


Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys 
    210                 215                 220                 


Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly 
225                 230                 235                 240 


Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
            260                 265         


<210> 9007
<211> 176
<212> PRT
<213> Homo sapiens

<400> 9007
Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


<210> 9008
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 9008
Met Leu Ser Val Val Glu Asn Gly Leu Asp Pro Gln Ala Ala Ile Pro 
1               5                   10                  15      


Val Ile Lys Lys Lys Leu Val Gly Ser Val Lys Ala Leu Gln Lys Gln 
            20                  25                  30          


Tyr Val Ser Leu Asp Thr Val Val Thr Ser Glu Asp Gly Asp Ala Asn 
        35                  40                  45              


Thr Met Cys Ser Ala Leu Glu Ala Val Phe Ile His Gly Leu His Ala 
    50                  55                  60                  


Lys His Ile Arg Ala Glu Ala Gly Gly Lys Arg Lys Lys Ser Ala His 
65                  70                  75                  80  


Gln Lys Pro Leu Pro Gln Pro Val Phe Trp Pro Leu Leu Lys Ala Val 
                85                  90                  95      


Thr His Lys His Ile Ile Ser Glu Leu Glu His Leu Thr Phe Val Asn 
            100                 105                 110         


Thr Asp Val Gly Arg Cys Arg Ala Trp Leu Arg Leu Ala Leu Asn Asp 
        115                 120                 125             


Gly Leu Met Glu Cys Tyr Leu Lys Leu Leu Leu Gln Glu Gln Ala Arg 
    130                 135                 140                 


Leu His Glu Tyr Tyr Gln Pro Thr Ala Leu Leu Arg Asp Ala Glu Glu 
145                 150                 155                 160 


Gly Glu Phe Leu Leu Ser Phe Leu Gln Gly Leu Thr Ser Leu Ser Phe 
                165                 170                 175     


Glu Leu Ser Tyr Lys Ser Ala Ile Leu Asn Glu Trp Thr Leu Thr Pro 
            180                 185                 190         


Leu Ala Leu Ser Gly Leu Cys Pro Leu Ser Glu Leu Asp Pro Leu Ser 
        195                 200                 205             


Thr Ser Gly Ala Glu Leu Gln Arg Lys Glu Ser Leu Asp Ser Ile Ser 
    210                 215                 220                 


His Ser Ser Gly Ser Glu Asp Ile Glu Val His His Ser Gly His Lys 
225                 230                 235                 240 


Ile Arg Arg Asn Gln Lys Leu Thr Ala Ser Ser Leu Ser Leu Asp Thr 
                245                 250                 255     


Ala Ser Ser Ser Gln Leu Ser Cys Ser Leu Asn Ser Asp Ser Cys Leu 
            260                 265                 270         


Leu Gln Glu Asn Gly Ser Lys Ser Pro Asp His Cys Glu Glu Pro Met 
        275                 280                 285             


Ser Cys Asp Ser Asp Leu Gly Thr Ala Asn Ala Glu Asp Ser Asp Arg 
    290                 295                 300                 


Ser Leu Gln Glu Val Leu Leu Glu Phe Ser Lys Ala Gln Val Asn Ser 
305                 310                 315                 320 


Val Pro Thr Asn Gly Leu Ser Gln Glu Thr Glu Ile Pro Thr Pro Gln 
                325                 330                 335     


Ala Ser Leu Ser Leu His Gly Leu Asn Thr Ser Thr Tyr Leu His Cys 
            340                 345                 350         


Glu Ala Pro Ala Glu Pro Leu Pro Ala Gln Ala Ala Ser Gly Thr Gln 
        355                 360                 365             


Asp Gly Val His Val Gln Glu Pro Arg Pro Gln Ala Pro Ser Pro Leu 
    370                 375                 380                 


Asp Leu Gln Gln Pro Val Glu Ser Thr Ser Gly Gln Gln Pro Ser Ser 
385                 390                 395                 400 


Thr Val Ser Glu Thr Ala Arg Glu Val Gly Gln Gly Asn Gly Leu Gln 
                405                 410                 415     


Lys Ala Gln Ala His Asp Gly Ala Gly Leu Lys Leu Val Val Ser Ser 
            420                 425                 430         


Pro Thr Ser Pro Lys Asn Lys Ser Trp Ile Ser Glu Asp Asp Phe Tyr 
        435                 440                 445             


Arg Pro Ser Arg Glu Gln Pro Leu Glu Ser Ala Ser Asp His Pro Ile 
    450                 455                 460                 


Ala Ser Tyr Arg Gly Thr Pro Gly Ser Arg Pro Gly Leu His Arg His 
465                 470                 475                 480 


Phe Ser Gln Glu Pro Arg Lys Asn Cys Ser Leu Gly Ala Leu Asp Gln 
                485                 490                 495     


Ala Cys Val Pro Ser Pro Gly Arg Arg Gln Ala Gln Ala Ala Pro Ser 
            500                 505                 510         


Gln Gly His Lys Ser Phe Arg Val Val His Arg Arg Gln Met Gly Leu 
        515                 520                 525             


Ser Asn Pro Phe Arg Gly Leu Met Lys Leu Gly Thr Val Glu Arg Arg 
    530                 535                 540                 


Gly Ala Met Gly Ile Trp Lys Glu Leu Phe Cys Glu Leu Ser Pro Leu 
545                 550                 555                 560 


Glu Phe Arg Leu Tyr Leu Ser Asn Glu Glu His Thr Cys Val Glu Asn 
                565                 570                 575     


Cys Ser Leu Leu Arg Cys Glu Ser Val Gly Pro Ala His Ser Asp Gly 
            580                 585                 590         


Arg Phe Glu Leu Val Phe Ser Gly Lys Lys Leu Ala Leu Arg Ala Ser 
        595                 600                 605             


Ser Gln Asp Glu Ala Glu Asp Trp Leu Asp Arg Val Arg Glu Ala Leu 
    610                 615                 620                 


Gln Lys Val Arg Pro Gln Gln Glu Asp Glu Trp Val Asn Val Gln Tyr 
625                 630                 635                 640 


Pro Asp Gln Pro Glu Glu Pro Pro Glu Ala Pro Gln Gly Cys Leu Ser 
                645                 650                 655     


Pro Ser Asp Leu Leu Ser Glu Pro Ala Ala Leu Gln Gly Thr Gln Phe 
            660                 665                 670         


Asp Trp Ser Ser Ala Gln Val Pro Glu Pro Asp Ala Ile Lys Glu Ser 
        675                 680                 685             


Leu Leu Tyr Leu Tyr Met Asp Arg Thr Trp Met Pro Tyr Ile Phe Ser 
    690                 695                 700                 


Leu Ser Leu Glu Ala Leu Lys Cys Phe Arg Ile Arg Asn Asn Glu Lys 
705                 710                 715                 720 


Met Leu Ser Asp Ser His Gly Val Glu Thr Ile Arg Asp Ile Leu Pro 
                725                 730                 735     


Asp Thr Ser Leu Gly Gly Pro Ser Phe Phe Lys Ile Ile Thr Ala Lys 
            740                 745                 750         


Ala Val Leu Lys Leu Gln Ala Gly Asn Ala Glu Glu Ala Ala Leu Trp 
        755                 760                 765             


Arg Asp Leu Val Arg Lys Val Leu Ala Ser Tyr Leu Glu Thr Ala Glu 
    770                 775                 780                 


Glu Ala Val Thr Leu Gly Gly Ser Leu Asp Glu Asn Cys Gln Glu Val 
785                 790                 795                 800 


Leu Lys Phe Ala Thr Arg Glu Asn Gly Phe Leu Leu Gln Tyr Leu Val 
                805                 810                 815     


Ala Ile Pro Met Glu Lys Gly Leu Asp Ser Gln Gly Cys Phe Cys Ala 
            820                 825                 830         


Gly Cys Ser Arg Gln Ile Gly Phe Ser Phe Val Arg Pro Lys Leu Cys 
        835                 840                 845             


Ala Phe Ser Gly Leu Tyr Tyr Cys Asp Ile Cys His Gln Asp Asp Ala 
    850                 855                 860                 


Ser Val Ile Pro Ala Arg Ile Ile His Asn Trp Asp Leu Thr Lys Arg 
865                 870                 875                 880 


Pro Ile Cys Arg Gln Ala Leu Lys Phe Leu Thr Gln Ile Arg Ala Gln 
                885                 890                 895     


Pro Leu Ile Asn Leu Gln Met Val Asn Ala Ser Leu Tyr Glu His Val 
            900                 905                 910         


Glu Arg Met His Leu Ile Gly Arg Arg Arg Glu Gln Leu Lys Leu Leu 
        915                 920                 925             


Gly Asp Tyr Leu Gly Leu Cys Arg Ser Gly Ala Leu Lys Glu Leu Ser 
    930                 935                 940                 


Lys Arg Leu Asn His Arg Asn Tyr Leu Leu Glu Ser Pro His Arg Phe 
945                 950                 955                 960 


Ser Val Ala Asp Leu Gln Gln Ile Ala Asp Gly Val Tyr Glu Gly Phe 
                965                 970                 975     


Leu Lys Ala Leu Ile Glu Phe Ala Ser Gln His Val Tyr His Cys Asp 
            980                 985                 990         


Leu Cys Thr Gln Arg Gly Phe Ile  Cys Gln Ile Cys Gln  His His Asp 
        995                 1000                 1005             


Ile Ile  Phe Pro Phe Glu Phe  Asp Thr Thr Val Arg  Cys Ala Glu 
    1010                 1015                 1020             


Cys Lys  Thr Val Phe His Gln  Ser Cys Gln Ala Val  Val Lys Lys 
    1025                 1030                 1035             


Gly Cys  Pro Arg Cys Ala Arg  Arg Arg Lys Tyr Gln  Glu Gln Asn 
    1040                 1045                 1050             


Ile Phe  Ala 
    1055     


<210> 9009
<211> 129
<212> PRT
<213> Homo sapiens

<400> 9009
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 9010
<211> 115
<212> PRT
<213> Homo sapiens

<400> 9010
Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Val Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Gly Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 


<210> 9011
<211> 632
<212> PRT
<213> Homo sapiens

<400> 9011
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                165                 170                 175     


Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
            180                 185                 190         


Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
        195                 200                 205             


Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
    210                 215                 220                 


Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
225                 230                 235                 240 


Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                245                 250                 255     


Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
            260                 265                 270         


Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
        275                 280                 285             


Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys Gly 
    290                 295                 300                 


Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys Arg 
305                 310                 315                 320 


Val Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys Ile 
                325                 330                 335     


Pro Thr Leu Ile Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu Ala 
            340                 345                 350         


Asp Phe Val Ser Gln Thr Ser Pro Met Ile Pro Ser Ile Val Val His 
        355                 360                 365             


Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Thr Gly Leu Tyr 
    370                 375                 380                 


Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys Phe 
385                 390                 395                 400 


Leu Arg Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile His 
                405                 410                 415     


Ala Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu Pro 
            420                 425                 430         


Leu Leu Thr Phe Arg Leu Asn Arg Ala Phe Met Glu Ala Ala Glu Ile 
        435                 440                 445             


Thr Asp Glu Asp Asn Ser Ile Ala Ala Met Tyr Gln Ala Val Gly Glu 
    450                 455                 460                 


Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His Leu 
465                 470                 475                 480 


Gln Arg Val Ala Gln Ser Pro His Thr Lys Met Asp Val Ala Asn Leu 
                485                 490                 495     


Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Ala Val Pro Asn Pro 
            500                 505                 510         


Asp Pro Val Thr Met Leu Gln Asp Ile Lys Arg Gln Pro Lys Val Val 
        515                 520                 525             


Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Ser Gln Phe Met Met 
    530                 535                 540                 


Val Glu Gln Glu Asn Ile Asp Pro Leu His Val Ile Glu Asn Ser Asn 
545                 550                 555                 560 


Ala Phe Ser Thr Pro Gln Thr Pro Asp Ile Lys Val Ser Leu Leu Gly 
                565                 570                 575     


Pro Val Thr Thr Pro Glu His Gln Leu Leu Lys Thr Pro Ser Ser Ser 
            580                 585                 590         


Ser Leu Ser Gln Arg Val Arg Ser Thr Leu Thr Lys Asn Thr Pro Arg 
        595                 600                 605             


Phe Gly Ser Lys Ser Lys Ser Ala Thr Asn Leu Gly Arg Gln Gly Asn 
    610                 615                 620                 


Phe Phe Ala Ser Pro Met Leu Lys 
625                 630         


<210> 9012
<211> 129
<212> PRT
<213> Homo sapiens

<400> 9012
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 9013
<211> 1739
<212> PRT
<213> Homo sapiens

<400> 9013
Met Met Glu Gly Asn Gly Thr Glu Asn Ser Cys Ser Arg Thr Arg Gly 
1               5                   10                  15      


Trp Leu Gln Gln Asp Asn Asp Ala Lys Pro Trp Leu Trp Lys Phe Ser 
            20                  25                  30          


Asn Cys Phe Ser Arg Pro Glu Gln Thr Leu Pro His Ser Pro Gln Thr 
        35                  40                  45              


Lys Glu Tyr Met Glu Asn Lys Lys Val Ala Val Glu Leu Lys Asp Val 
    50                  55                  60                  


Pro Ser Pro Leu His Ala Gly Ser Lys Leu Phe Pro Ala Val Pro Leu 
65                  70                  75                  80  


Pro Asp Ile Arg Ser Leu Gln Gln Pro Lys Ile Gln Leu Ser Ser Val 
                85                  90                  95      


Pro Lys Val Ser Cys Cys Ala His Cys Pro Asn Glu Pro Ser Thr Ser 
            100                 105                 110         


Pro Met Arg Phe Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Ser Ser 
        115                 120                 125             


Leu Ile His Pro Gly Ala Leu Leu Asp Ser Gln Ser Thr Arg Thr Ile 
    130                 135                 140                 


Thr Cys Gln Val Gly Ser Gly Phe Ala Phe Gln Ser Ala Ser Ser Leu 
145                 150                 155                 160 


Gln Asn Ala Ser Ala Arg Asn Asn Leu Ala Gly Ile Ala Ser Asp Phe 
                165                 170                 175     


Pro Ser Met Cys Leu Glu Ser Asn Leu Ser Ser Cys Lys His Leu Pro 
            180                 185                 190         


Cys Cys Gly Lys Leu His Phe Gln Ser Cys His Gly Asn Val His Lys 
        195                 200                 205             


Leu His Gln Phe Pro Ser Leu Gln Gly Cys Thr Ser Ala Gly Tyr Phe 
    210                 215                 220                 


Pro Cys Ser Asp Phe Thr Ser Gly Ala Pro Gly His Leu Glu Glu His 
225                 230                 235                 240 


Ile Ser Gln Ser Glu Leu Thr Pro His Leu Cys Thr Asn Ser Leu His 
                245                 250                 255     


Leu Asn Val Val Pro Pro Val Cys Leu Lys Gly Ser Leu Tyr Cys Glu 
            260                 265                 270         


Asp Cys Leu Asn Lys Pro Ala Arg Asn Ser Ile Ile Asp Ala Ala Lys 
        275                 280                 285             


Val Trp Pro Asn Ile Pro Pro Pro Asn Thr Gln Pro Ala Pro Leu Ala 
    290                 295                 300                 


Val Pro Leu Cys Asn Gly Cys Gly Thr Lys Gly Thr Gly Lys Glu Thr 
305                 310                 315                 320 


Thr Leu Leu Leu Ala Thr Ser Leu Gly Lys Ala Ala Ser Lys Phe Glu 
                325                 330                 335     


Val Ala Val Ala Gly Gln Val Leu Glu Asn Leu Pro Pro Ile Gly Val 
            340                 345                 350         


Phe Trp Asp Ile Glu Asn Cys Ser Val Pro Ser Gly Arg Ser Ala Thr 
        355                 360                 365             


Ala Val Val Gln Arg Ile Arg Glu Lys Phe Phe Lys Gly His Arg Glu 
    370                 375                 380                 


Ala Glu Phe Ile Cys Val Cys Asp Ile Ser Lys Glu Asn Lys Glu Val 
385                 390                 395                 400 


Ile Gln Glu Leu Asn Asn Cys Gln Val Thr Val Ala His Ile Asn Ala 
                405                 410                 415     


Thr Ala Lys Asn Ala Ala Asp Asp Lys Leu Arg Gln Ser Leu Arg Arg 
            420                 425                 430         


Phe Ala Asn Thr His Thr Ala Pro Ala Thr Val Val Leu Val Ser Thr 
        435                 440                 445             


Asp Val Asn Phe Ala Leu Glu Leu Ser Asp Leu Arg His Arg His Gly 
    450                 455                 460                 


Phe His Ile Ile Leu Val His Lys Asn Gln Ala Ser Glu Ala Leu Leu 
465                 470                 475                 480 


His His Ala Asn Glu Leu Ile Arg Phe Glu Glu Phe Ile Ser Asp Leu 
                485                 490                 495     


Pro Pro Arg Leu Pro Leu Lys Met Pro Gln Cys His Thr Leu Leu Tyr 
            500                 505                 510         


Val Tyr Asn Leu Pro Ala Asn Lys Asp Gly Lys Ser Val Ser Asn Arg 
        515                 520                 525             


Leu Arg Arg Leu Ser Asp Asn Cys Gly Gly Lys Val Leu Ser Ile Thr 
    530                 535                 540                 


Gly Cys Ser Ala Ile Leu Arg Phe Ile Asn Gln Asp Ser Ala Glu Arg 
545                 550                 555                 560 


Ala Gln Lys Arg Met Glu Asn Glu Asp Val Phe Gly Asn Arg Ile Ile 
                565                 570                 575     


Val Ser Phe Thr Pro Lys Asn Arg Glu Leu Cys Glu Thr Lys Ser Ser 
            580                 585                 590         


Asn Ala Ile Ala Asp Lys Val Lys Ser Pro Lys Lys Leu Lys Asn Pro 
        595                 600                 605             


Lys Leu Cys Leu Ile Lys Asp Ala Ser Glu Gln Ser Ser Ser Ala Lys 
    610                 615                 620                 


Ala Thr Pro Gly Lys Gly Ser Gln Ala Asn Ser Gly Ser Ala Thr Lys 
625                 630                 635                 640 


Asn Thr Asn Val Lys Ser Leu Gln Glu Leu Cys Arg Met Glu Ser Lys 
                645                 650                 655     


Thr Gly His Arg Asn Ser Glu His Gln Gln Gly His Leu Arg Leu Val 
            660                 665                 670         


Val Pro Thr His Gly Asn Ser Ser Ala Ala Val Ser Thr Pro Lys Asn 
        675                 680                 685             


Ser Gly Val Ala Glu Pro Val Tyr Lys Thr Ser Gln Lys Lys Glu Asn 
    690                 695                 700                 


Leu Ser Ala Arg Ser Val Thr Ser Ser Pro Val Glu Lys Lys Asp Lys 
705                 710                 715                 720 


Glu Glu Thr Val Phe Gln Val Ser Tyr Pro Ser Ala Phe Ser Lys Leu 
                725                 730                 735     


Val Ala Ser Arg Gln Val Ser Pro Leu Leu Ala Ser Gln Ser Trp Ser 
            740                 745                 750         


Ser Arg Ser Met Ser Pro Asn Leu Leu Asn Arg Ala Ser Pro Leu Ala 
        755                 760                 765             


Phe Asn Ile Ala Asn Ser Ser Ser Glu Ala Asp Cys Pro Asp Pro Phe 
    770                 775                 780                 


Ala Asn Gly Ala Asp Val Gln Val Ser Asn Ile Asp Tyr Arg Leu Ser 
785                 790                 795                 800 


Arg Lys Glu Leu Gln Gln Leu Leu Gln Glu Ala Phe Ala Arg His Gly 
                805                 810                 815     


Lys Val Lys Ser Val Glu Leu Ser Pro His Thr Asp Tyr Gln Leu Lys 
            820                 825                 830         


Ala Val Val Gln Met Glu Asn Leu Gln Asp Ala Ile Gly Ala Val Asn 
        835                 840                 845             


Ser Leu His Arg Tyr Lys Ile Gly Ser Lys Lys Ile Leu Val Ser Leu 
    850                 855                 860                 


Ala Thr Gly Ala Ala Ser Lys Ser Leu Ser Leu Leu Ser Ala Glu Thr 
865                 870                 875                 880 


Met Ser Val Leu Gln Asp Ala Pro Ala Cys Cys Leu Pro Leu Phe Lys 
                885                 890                 895     


Phe Thr Asp Ile Tyr Glu Lys Lys Phe Gly His Lys Leu Asn Val Ser 
            900                 905                 910         


Asp Leu Tyr Lys Leu Thr Asp Thr Val Ala Ile Arg Glu Gln Gly Asn 
        915                 920                 925             


Gly Arg Leu Val Cys Leu Leu Pro Ser Ser Gln Ala Arg Gln Ser Pro 
    930                 935                 940                 


Leu Gly Ser Ser Gln Ser His Asp Gly Ser Ser Thr Asn Cys Ser Pro 
945                 950                 955                 960 


Ile Ile Phe Glu Glu Leu Glu Tyr His Glu Pro Val Cys Arg Gln His 
                965                 970                 975     


Cys Ser Asn Lys Asp Phe Ser Glu His Glu Phe Asp Pro Asp Ser Tyr 
            980                 985                 990         


Lys Ile Pro Phe Val Ile Leu Ser  Leu Lys Thr Phe Ala  Pro Gln Val 
        995                 1000                 1005             


His Ser  Leu Leu Gln Thr His  Glu Gly Thr Val Pro  Leu Leu Ser 
    1010                 1015                 1020             


Phe Pro  Asp Cys Tyr Ile Ala  Glu Phe Gly Asp Leu  Glu Val Val 
    1025                 1030                 1035             


Gln Glu  Asn Gln Gly Gly Val  Pro Leu Glu His Phe  Ile Thr Cys 
    1040                 1045                 1050             


Val Pro  Gly Val Asn Ile Ala  Thr Ala Gln Asn Gly  Ile Lys Val 
    1055                 1060                 1065             


Val Lys  Trp Ile His Asn Lys  Pro Pro Pro Pro Asn  Thr Asp Pro 
    1070                 1075                 1080             


Trp Leu  Leu Arg Ser Lys Ser  Pro Val Gly Asn Pro  Gln Leu Ile 
    1085                 1090                 1095             


Gln Phe  Ser Arg Glu Val Ile  Asp Leu Leu Lys Ser  Gln Pro Ser 
    1100                 1105                 1110             


Cys Val  Ile Pro Ile Ser His  Phe Ile Pro Ser Tyr  His His His 
    1115                 1120                 1125             


Phe Ala  Lys Gln Cys Arg Val  Ser Asp Tyr Gly Tyr  Ser Lys Leu 
    1130                 1135                 1140             


Ile Glu  Leu Leu Glu Ala Val  Pro His Val Leu Gln  Ile Leu Gly 
    1145                 1150                 1155             


Met Gly  Ser Lys Arg Leu Leu  Thr Leu Thr His Arg  Ala Gln Val 
    1160                 1165                 1170             


Lys Arg  Phe Thr Gln Asp Leu  Leu Lys Leu Leu Lys  Ser Gln Ala 
    1175                 1180                 1185             


Ser Lys  Gln Val Ile Val Arg  Glu Phe Ser Gln Ala  Tyr His Trp 
    1190                 1195                 1200             


Cys Phe  Ser Lys Asp Trp Asp  Val Thr Glu Tyr Gly  Val Cys Glu 
    1205                 1210                 1215             


Leu Ile  Asp Ile Val Ser Glu  Ile Pro Asp Thr Thr  Ile Cys Leu 
    1220                 1225                 1230             


Ser Gln  Gln Asp Asn Glu Met  Val Ile Cys Ile Pro  Lys Arg Glu 
    1235                 1240                 1245             


Arg Thr  Gln Asp Glu Ile Glu  Arg Thr Lys Gln Phe  Ser Lys Asp 
    1250                 1255                 1260             


Val Val  Asp Leu Leu Arg His  Gln Pro His Phe Arg  Met Pro Phe 
    1265                 1270                 1275             


Asn Lys  Phe Ile Pro Ser Tyr  His His His Phe Gly  Arg Gln Cys 
    1280                 1285                 1290             


Lys Leu  Ala Tyr Tyr Gly Phe  Thr Lys Leu Leu Glu  Leu Phe Glu 
    1295                 1300                 1305             


Ala Ile  Pro Asp Thr Leu Gln  Val Leu Glu Cys Gly  Glu Glu Lys 
    1310                 1315                 1320             


Ile Leu  Thr Leu Thr Glu Val  Glu Arg Phe Lys Ala  Leu Ala Ala 
    1325                 1330                 1335             


Gln Phe  Val Lys Leu Leu Arg  Ser Gln Lys Asp Asn  Cys Leu Met 
    1340                 1345                 1350             


Met Thr  Asp Leu Leu Thr Glu  Tyr Ala Lys Thr Phe  Gly Tyr Thr 
    1355                 1360                 1365             


Phe Arg  Leu Gln Asp Tyr Asp  Val Ser Ser Ile Ser  Ala Leu Thr 
    1370                 1375                 1380             


Gln Lys  Leu Cys His Val Val  Lys Val Ala Asp Ile  Glu Ser Gly 
    1385                 1390                 1395             


Arg Gln  Ile Gln Leu Ile Asn  Arg Lys Ser Leu Arg  Ser Leu Thr 
    1400                 1405                 1410             


Ala Gln  Leu Leu Val Leu Leu  Met Ser Trp Glu Gly  Thr Thr His 
    1415                 1420                 1425             


Leu Ser  Val Glu Glu Leu Lys  Arg His Tyr Glu Ser  Thr His Asn 
    1430                 1435                 1440             


Thr Pro  Leu Asn Pro Cys Glu  Tyr Gly Phe Met Thr  Leu Thr Glu 
    1445                 1450                 1455             


Leu Leu  Lys Ser Leu Pro Tyr  Leu Val Glu Val Phe  Thr Asn Asp 
    1460                 1465                 1470             


Lys Met  Glu Glu Cys Val Lys  Leu Thr Ser Leu Tyr  Leu Phe Ala 
    1475                 1480                 1485             


Lys Asn  Val Arg Ser Leu Leu  His Thr Tyr His Tyr  Gln Gln Ile 
    1490                 1495                 1500             


Phe Leu  His Glu Phe Ser Met  Ala Tyr Thr Lys Tyr  Val Gly Glu 
    1505                 1510                 1515             


Thr Leu  Gln Pro Lys Thr Tyr  Gly His Ser Ser Val  Glu Glu Leu 
    1520                 1525                 1530             


Leu Gly  Ala Ile Pro Gln Val  Val Trp Ile Lys Gly  His Gly His 
    1535                 1540                 1545             


Lys Arg  Ile Val Val Leu Lys  Asn Asp Met Lys Ser  Arg Leu Ser 
    1550                 1555                 1560             


Ser Leu  Ser Leu Ser Pro Ala  Asn His Glu Asn Gln  Pro Ser Glu 
    1565                 1570                 1575             


Gly Glu  Arg Ile Leu Glu Val  Pro Glu Ser His Thr  Ala Ser Glu 
    1580                 1585                 1590             


Leu Lys  Leu Gly Ala Asp Gly  Ser Gly Pro Ser His  Thr Glu Gln 
    1595                 1600                 1605             


Glu Leu  Leu Arg Leu Thr Asp  Asp Ser Pro Val Asp  Leu Leu Cys 
    1610                 1615                 1620             


Ala Pro  Val Pro Ser Cys Leu  Pro Ser Pro Gln Leu  Arg Pro Asp 
    1625                 1630                 1635             


Pro Val  Ile Leu Gln Ser Ala  Asp Leu Ile Gln Phe  Glu Glu Arg 
    1640                 1645                 1650             


Pro Gln  Glu Pro Ser Glu Ile  Met Ile Leu Asn Gln  Glu Glu Lys 
    1655                 1660                 1665             


Met Glu  Ile Pro Ile Pro Gly  Lys Ser Lys Thr Leu  Thr Ser Asp 
    1670                 1675                 1680             


Ser Ser  Ser Ser Cys Ile Ser  Ala Ala Val Pro Val  Pro Pro Cys 
    1685                 1690                 1695             


Pro Ser  Ser Glu Thr Ser Glu  Ser Leu Leu Ser Lys  Asp Pro Val 
    1700                 1705                 1710             


Glu Ser  Pro Ala Lys Lys Gln  Pro Lys Asn Arg Val  Lys Leu Ala 
    1715                 1720                 1725             


Ala Asn  Phe Ser Leu Ala Pro  Ile Thr Lys Leu 
    1730                 1735                 


<210> 9014
<211> 129
<212> PRT
<213> Homo sapiens

<400> 9014
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 9015
<211> 143
<212> PRT
<213> Homo sapiens

<400> 9015
Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro 
    130                 135                 140             


<210> 9016
<211> 51
<212> PRT
<213> Homo sapiens

<400> 9016
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Thr Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Thr His 
    50      


<210> 9017
<211> 633
<212> PRT
<213> Homo sapiens

<400> 9017
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Thr Tyr Ile Pro Asn Thr Lys Val Glu Cys 
            20                  25                  30          


His Tyr Thr Leu Pro Pro Gly Thr Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Thr Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Thr Thr Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Thr Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Thr Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Thr Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Thr Glu 
                165                 170                 175     


Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Thr Ala Arg 
            180                 185                 190         


Gln Glu His Thr Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser 
        195                 200                 205             


His Gly Glu Ile Thr Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly 
    210                 215                 220                 


Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Thr Ile 
225                 230                 235                 240 


Ser Glu Lys Val Leu Thr Lys Glu Val Glu Leu Asp Arg Leu Arg Asp 
                245                 250                 255     


Thr Val Lys Ala Leu Thr Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu 
            260                 265                 270         


Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Gln Val 
        275                 280                 285             


Ala Gln Gln Glu Asn His His Leu Asn Leu Asp Leu Lys Glu Ala Lys 
    290                 295                 300                 


Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln Arg Leu Lys Asp Lys 
305                 310                 315                 320 


Val Ala Gln Met Lys Asp Thr Leu Gly Gln Ala Gln Gln Arg Val Ala 
                325                 330                 335     


Glu Leu Glu Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala 
            340                 345                 350         


Ala Ser Ser Gln Gln Lys Ala Thr Leu Leu Gly Glu Glu Leu Ala Ser 
        355                 360                 365             


Ala Ala Ala Ala Arg Asp Arg Thr Ile Ala Glu Leu His Arg Ser Arg 
    370                 375                 380                 


Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His 
385                 390                 395                 400 


Leu Lys Glu Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu 
                405                 410                 415     


Gln Ser Val Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu 
            420                 425                 430         


Ile Leu Arg Leu Glu Lys Ala Val Gln Glu Glu Arg Thr Gln Asn Gln 
        435                 440                 445             


Val Phe Lys Thr Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln 
    450                 455                 460                 


Leu Ser Glu Ser Lys Arg Glu Leu Thr Glu Leu Arg Ser Ala Leu Arg 
465                 470                 475                 480 


Val Leu Gln Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu 
                485                 490                 495     


Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp 
            500                 505                 510         


Glu Lys Trp Asn Glu Asp Ala Thr Thr Glu Asp Glu Glu Ala Ala Val 
        515                 520                 525             


Gly Leu Ser Cys Pro Ala Ala Leu Thr Asp Ser Glu Asp Glu Ser Pro 
    530                 535                 540                 


Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro 
545                 550                 555                 560 


Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile 
                565                 570                 575     


Ser Gln Pro Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp 
            580                 585                 590         


Ser Ser Ser Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala 
        595                 600                 605             


Ala Val Gln Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu 
    610                 615                 620                 


Gly Ser Ala Phe Tyr Asp Met Ala Arg 
625                 630             


<210> 9018
<211> 269
<212> PRT
<213> Homo sapiens

<400> 9018
Met Lys Thr Pro Val Glu Leu Ala Val Ser Gly Met Gln Thr Leu Gly 
1               5                   10                  15      


Leu Gln His Arg Cys Arg Gly Gly Tyr Arg Val Lys Ala Arg Thr Ser 
            20                  25                  30          


Tyr Val Asp Glu Thr Leu Phe Gly Ser Pro Ala Gly Thr Arg Pro Thr 
        35                  40                  45              


Pro Pro Asp Phe Asp Pro Pro Trp Val Glu Lys Ala Asn Arg Thr Arg 
    50                  55                  60                  


Gly Val Gly Lys Glu Ala Ser Lys Ala Leu Gly Ala Lys Gly Ser Cys 
65                  70                  75                  80  


Glu Thr Thr Pro Ser Arg Gly Ser Thr Pro Thr Leu Thr Pro Arg Lys 
                85                  90                  95      


Lys Asn Lys Tyr Arg Pro Ile Ser His Thr Pro Ser Tyr Cys Asp Glu 
            100                 105                 110         


Ser Leu Phe Gly Ser Arg Ser Glu Gly Ala Ser Phe Gly Ala Pro Arg 
        115                 120                 125             


Met Ala Lys Gly Asp Ala Ala Lys Leu Arg Ala Leu Leu Trp Thr Pro 
    130                 135                 140                 


Pro Pro Thr Pro Arg Gly Ser His Ser Pro Arg Pro Arg Glu Ala Pro 
145                 150                 155                 160 


Leu Arg Ala Ile His Pro Ala Gly Pro Ser Lys Thr Glu Pro Gly Pro 
                165                 170                 175     


Ala Ala Asp Ser Gln Lys Leu Ser Met Gly Gly Leu His Ser Ser Arg 
            180                 185                 190         


Pro Leu Lys Arg Gly Leu Ser His Ser Leu Thr His Leu Asn Val Pro 
        195                 200                 205             


Ser Thr Gly His Pro Ala Thr Ser Ala Pro His Thr Asn Gly Pro Gln 
    210                 215                 220                 


Asp Leu Arg Pro Ser Thr Ser Gly Val Thr Phe Arg Ser Pro Leu Val 
225                 230                 235                 240 


Thr Ser Arg Ala Arg Ser Val Ser Ile Ser Val Pro Ser Thr Pro Arg 
                245                 250                 255     


Arg Gly Gly Ala Thr Gln Lys Pro Lys Pro Pro Trp Lys 
            260                 265                 


<210> 9019
<211> 205
<212> PRT
<213> Homo sapiens

<400> 9019
Met Asp Lys Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser 
1               5                   10                  15      


Gly Thr Ala Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys 
            20                  25                  30          


Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser 
        35                  40                  45              


Ser Arg Phe Ile Lys Arg Lys Lys Phe Asp Asp Glu Leu Val Glu Ser 
    50                  55                  60                  


Ser Leu Ala Lys Ser Ser Thr Arg Ala Lys Gly Ala Ser Gly Val Glu 
65                  70                  75                  80  


Pro Gly Arg Cys Ser Gly Ser Glu Pro Ser Ser Ser Glu Lys Lys Lys 
                85                  90                  95      


Val Ser Lys Ala Pro Ser Thr Pro Val Pro Pro Ser Pro Ala Pro Ala 
            100                 105                 110         


Pro Gly Leu Thr Lys Arg Val Lys Lys Ser Lys Gln Pro Leu Gln Val 
        115                 120                 125             


Thr Lys Asp Leu Gly Arg Trp Lys Pro Ala Asp Asp Leu Leu Leu Ile 
    130                 135                 140                 


Asn Ala Val Leu Gln Thr Asn Asp Leu Thr Ser Val His Leu Gly Val 
145                 150                 155                 160 


Lys Phe Ser Cys Arg Phe Thr Leu Arg Glu Val Gln Glu Arg Trp Tyr 
                165                 170                 175     


Ala Leu Leu Tyr Asp Pro Val Ile Ser Lys Leu Ala Cys Gln Ala Met 
            180                 185                 190         


Arg Gln Leu His Pro Glu Ala Ile Ala Ala Ile Gln Ser 
        195                 200                 205 


<210> 9020
<211> 179
<212> PRT
<213> Homo sapiens

<400> 9020
Met Asp Trp Thr Pro Arg Leu Pro Ser Arg His Ile Ile Ser Glu Leu 
1               5                   10                  15      


Glu His Leu Thr Phe Val Asn Thr Asp Val Gly Arg Cys Arg Ala Trp 
            20                  25                  30          


Leu Arg Leu Ala Leu Asn Asp Gly Leu Met Glu Cys Tyr Leu Lys Leu 
        35                  40                  45              


Leu Leu Gln Glu Gln Ala Arg Leu Gln Leu Gln Arg Lys Glu Ser Leu 
    50                  55                  60                  


Asp Ser Ile Ser His Ser Ser Gly Ser Glu Asp Ile Glu Val His His 
65                  70                  75                  80  


Ser Gly His Lys Ile Arg Arg Asn Gln Lys Leu Thr Ala Ser Ser Leu 
                85                  90                  95      


Ser Leu Asp Thr Ala Ser Ser Ser Gln Leu Ser Cys Ser Leu Asn Ser 
            100                 105                 110         


Asp Ser Cys Leu Leu Gln Glu Asn Gly Ser Lys Ser Pro Asp His Cys 
        115                 120                 125             


Glu Glu Pro Met Ser Cys Asp Ser Asp Leu Gly Thr Ala Asn Ala Glu 
    130                 135                 140                 


Asp Ser Asp Arg Ser Leu Gln Glu Lys Thr Arg Ala Gly Ser Gln Arg 
145                 150                 155                 160 


Met Thr Ser Thr Gly Leu Pro Gly Ser Asn Pro Trp Arg Val Leu Gln 
                165                 170                 175     


Thr Thr Gln 
            


<210> 9021
<211> 244
<212> PRT
<213> Homo sapiens

<400> 9021
Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210> 9022
<211> 185
<212> PRT
<213> Homo sapiens

<400> 9022
Met Asp Lys Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser 
1               5                   10                  15      


Gly Thr Ala Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys 
            20                  25                  30          


Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser 
        35                  40                  45              


Ser Arg Phe Ile Lys Arg Lys Lys Phe Asp Asp Glu Leu Val Glu Ser 
    50                  55                  60                  


Ser Leu Ala Lys Ser Ser Thr Arg Ala Lys Gly Ala Ser Gly Val Glu 
65                  70                  75                  80  


Pro Gly Arg Cys Ser Gly Ser Glu Pro Ser Ser Ser Glu Lys Lys Lys 
                85                  90                  95      


Val Ser Lys Ala Pro Ser Thr Pro Val Pro Pro Ser Pro Ala Pro Ala 
            100                 105                 110         


Pro Gly Leu Thr Lys Arg Val Lys Lys Ser Lys Gln Pro Leu Gln Val 
        115                 120                 125             


Thr Lys Asp Leu Gly Arg Trp Lys Pro Ala Asp Asp Leu Leu Leu Ile 
    130                 135                 140                 


Asn Ala Val Leu Gln Thr Asn Asp Leu Thr Ser Val His Leu Gly Val 
145                 150                 155                 160 


Lys Phe Ser Cys Arg Phe Thr Leu Arg Glu Val Gln Glu Arg Trp Tyr 
                165                 170                 175     


Ala Leu Leu Tyr Asp Pro Val Ile Ser 
            180                 185 


<210> 9023
<211> 1000
<212> PRT
<213> Homo sapiens

<400> 9023
Met Val Glu Cys Phe Glu Ser Gly Gly Thr Arg Leu Ser Leu Ser Ser 
1               5                   10                  15      


Phe Asn Val Ser Cys Asp Ser Leu Arg Glu Gln Leu Arg Glu Trp Arg 
            20                  25                  30          


Cys Phe Gln Trp Trp Arg Met Asp Trp Thr Pro Arg Leu Pro Ser Arg 
        35                  40                  45              


His Ile Ile Ser Glu Leu Glu His Leu Thr Phe Val Asn Thr Asp Val 
    50                  55                  60                  


Gly Arg Cys Arg Ala Trp Leu Arg Leu Ala Leu Asn Asp Gly Leu Met 
65                  70                  75                  80  


Glu Cys Tyr Leu Lys Leu Leu Leu Gln Glu Gln Ala Arg Leu His Glu 
                85                  90                  95      


Tyr Tyr Gln Pro Thr Ala Leu Leu Arg Asp Ala Glu Glu Gly Glu Phe 
            100                 105                 110         


Leu Leu Ser Phe Leu Gln Gly Leu Thr Ser Leu Ser Phe Glu Leu Ser 
        115                 120                 125             


Tyr Lys Ser Ala Ile Leu Asn Glu Trp Thr Leu Thr Pro Leu Ala Leu 
    130                 135                 140                 


Ser Gly Leu Cys Pro Leu Ser Glu Leu Asp Pro Leu Ser Thr Ser Gly 
145                 150                 155                 160 


Ala Glu Leu Gln Arg Lys Glu Ser Leu Asp Ser Ile Ser His Ser Ser 
                165                 170                 175     


Gly Ser Glu Asp Ile Glu Val His His Ser Gly His Lys Ile Arg Arg 
            180                 185                 190         


Asn Gln Lys Leu Thr Ala Ser Ser Leu Ser Leu Asp Thr Ala Ser Ser 
        195                 200                 205             


Ser Gln Leu Ser Cys Ser Leu Asn Ser Asp Ser Cys Leu Leu Gln Glu 
    210                 215                 220                 


Asn Gly Ser Lys Ser Pro Asp His Cys Glu Glu Pro Met Ser Cys Asp 
225                 230                 235                 240 


Ser Asp Leu Gly Thr Ala Asn Ala Glu Asp Ser Asp Arg Ser Leu Gln 
                245                 250                 255     


Glu Val Leu Leu Glu Phe Ser Lys Ala Gln Val Asn Ser Val Pro Thr 
            260                 265                 270         


Asn Gly Leu Ser Gln Glu Thr Glu Ile Pro Thr Pro Gln Ala Ser Leu 
        275                 280                 285             


Ser Leu His Gly Leu Asn Thr Ser Thr Tyr Leu His Cys Glu Ala Pro 
    290                 295                 300                 


Ala Glu Pro Leu Pro Ala Gln Ala Ala Ser Gly Thr Gln Asp Gly Val 
305                 310                 315                 320 


His Val Gln Glu Pro Arg Pro Gln Ala Pro Ser Pro Leu Asp Leu Gln 
                325                 330                 335     


Gln Pro Val Glu Ser Thr Ser Gly Gln Gln Pro Ser Ser Thr Val Ser 
            340                 345                 350         


Glu Thr Ala Arg Glu Val Gly Gln Gly Asn Gly Leu Gln Lys Ala Gln 
        355                 360                 365             


Ala His Asp Gly Ala Gly Leu Lys Leu Val Val Ser Ser Pro Thr Ser 
    370                 375                 380                 


Pro Lys Asn Lys Ser Trp Ile Ser Glu Asp Asp Phe Tyr Arg Pro Ser 
385                 390                 395                 400 


Arg Glu Gln Pro Leu Glu Ser Ala Ser Asp His Pro Ile Ala Ser Tyr 
                405                 410                 415     


Arg Gly Thr Pro Gly Ser Arg Pro Gly Leu His Arg His Phe Ser Gln 
            420                 425                 430         


Glu Pro Arg Lys Asn Cys Ser Leu Gly Ala Leu Asp Gln Ala Cys Val 
        435                 440                 445             


Pro Ser Pro Gly Arg Arg Gln Ala Gln Ala Ala Pro Ser Gln Gly His 
    450                 455                 460                 


Lys Ser Phe Arg Val Val His Arg Arg Gln Met Gly Leu Ser Asn Pro 
465                 470                 475                 480 


Phe Arg Gly Leu Met Lys Leu Gly Thr Val Glu Arg Arg Gly Ala Met 
                485                 490                 495     


Gly Ile Trp Lys Glu Leu Phe Cys Glu Leu Ser Pro Leu Glu Phe Arg 
            500                 505                 510         


Leu Tyr Leu Ser Asn Glu Glu His Thr Cys Val Glu Asn Cys Ser Leu 
        515                 520                 525             


Leu Arg Cys Glu Ser Val Gly Pro Ala His Ser Asp Gly Arg Phe Glu 
    530                 535                 540                 


Leu Val Phe Ser Gly Lys Lys Leu Ala Leu Arg Ala Ser Ser Gln Asp 
545                 550                 555                 560 


Glu Ala Glu Asp Trp Leu Asp Arg Val Arg Glu Ala Leu Gln Lys Val 
                565                 570                 575     


Arg Pro Gln Gln Glu Asp Glu Trp Val Asn Val Gln Tyr Pro Asp Gln 
            580                 585                 590         


Pro Glu Glu Pro Pro Glu Ala Pro Gln Gly Cys Leu Ser Pro Ser Asp 
        595                 600                 605             


Leu Leu Ser Glu Pro Ala Ala Leu Gln Gly Thr Gln Phe Asp Trp Ser 
    610                 615                 620                 


Ser Ala Gln Val Pro Glu Pro Asp Ala Ile Lys Glu Ser Leu Leu Tyr 
625                 630                 635                 640 


Leu Tyr Met Asp Arg Thr Trp Met Pro Tyr Ile Phe Ser Leu Ser Leu 
                645                 650                 655     


Glu Ala Leu Lys Cys Phe Arg Ile Arg Asn Asn Glu Lys Met Leu Ser 
            660                 665                 670         


Asp Ser His Gly Val Glu Thr Ile Arg Asp Ile Leu Pro Asp Thr Ser 
        675                 680                 685             


Leu Gly Gly Pro Ser Phe Phe Lys Ile Ile Thr Ala Lys Ala Val Leu 
    690                 695                 700                 


Lys Leu Gln Ala Gly Asn Ala Glu Glu Ala Ala Leu Trp Arg Asp Leu 
705                 710                 715                 720 


Val Arg Lys Val Leu Ala Ser Tyr Leu Glu Thr Ala Glu Glu Ala Val 
                725                 730                 735     


Thr Leu Gly Gly Ser Leu Asp Glu Asn Cys Gln Glu Val Leu Lys Phe 
            740                 745                 750         


Ala Thr Arg Glu Asn Gly Phe Leu Leu Gln Tyr Leu Val Ala Ile Pro 
        755                 760                 765             


Met Glu Lys Gly Leu Asp Ser Gln Gly Cys Phe Cys Ala Gly Cys Ser 
    770                 775                 780                 


Arg Gln Ile Gly Phe Ser Phe Val Arg Pro Lys Leu Cys Ala Phe Ser 
785                 790                 795                 800 


Gly Leu Tyr Tyr Cys Asp Ile Cys His Gln Asp Asp Ala Ser Val Ile 
                805                 810                 815     


Pro Ala Arg Ile Ile His Asn Trp Asp Leu Thr Lys Arg Pro Ile Cys 
            820                 825                 830         


Arg Gln Ala Leu Lys Phe Leu Thr Gln Ile Arg Ala Gln Pro Leu Ile 
        835                 840                 845             


Asn Leu Gln Met Val Asn Ala Ser Leu Tyr Glu His Val Glu Arg Met 
    850                 855                 860                 


His Leu Ile Gly Arg Arg Arg Glu Gln Leu Lys Leu Leu Gly Asp Tyr 
865                 870                 875                 880 


Leu Gly Leu Cys Arg Ser Gly Ala Leu Lys Glu Leu Ser Lys Arg Leu 
                885                 890                 895     


Asn His Arg Asn Tyr Leu Leu Glu Ser Pro His Arg Phe Ser Val Ala 
            900                 905                 910         


Asp Leu Gln Gln Ile Ala Asp Gly Val Tyr Glu Gly Phe Ser Pro Lys 
        915                 920                 925             


Val Pro Ser Glu Ala Ala Gly Leu Arg Pro Trp Gly Ala Arg Ser Pro 
    930                 935                 940                 


Glu Ala Ala Ser Ala Phe Arg Cys Ile Asp Ser Ser His Leu Pro Ser 
945                 950                 955                 960 


Leu Arg Lys Val Val Pro Thr Leu Phe Leu Lys Cys Tyr Phe Met Gln 
                965                 970                 975     


Tyr Thr Val Pro Ser Glu Gln Gly Ser Gly Pro Glu Glu Ser Leu Gln 
            980                 985                 990         


Cys Ile Glu Gly Ile Ala Ala Val  
        995                 1000 


<210> 9024
<211> 174
<212> PRT
<213> Homo sapiens

<400> 9024
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr 
                165                 170                 


<210> 9025
<211> 967
<212> PRT
<213> Homo sapiens

<400> 9025
Met Asp Trp Thr Pro Arg Leu Pro Ser Arg His Ile Ile Ser Glu Leu 
1               5                   10                  15      


Glu His Leu Thr Phe Val Asn Thr Asp Val Gly Arg Cys Arg Ala Trp 
            20                  25                  30          


Leu Arg Leu Ala Leu Asn Asp Gly Leu Met Glu Cys Tyr Leu Lys Leu 
        35                  40                  45              


Leu Leu Gln Glu Gln Ala Arg Leu His Glu Tyr Tyr Gln Pro Thr Ala 
    50                  55                  60                  


Leu Leu Arg Asp Ala Glu Glu Gly Glu Phe Leu Leu Ser Phe Leu Gln 
65                  70                  75                  80  


Gly Leu Thr Ser Leu Ser Phe Glu Leu Ser Tyr Lys Ser Ala Ile Leu 
                85                  90                  95      


Asn Glu Trp Thr Leu Thr Pro Leu Ala Leu Ser Gly Leu Cys Pro Leu 
            100                 105                 110         


Ser Glu Leu Asp Pro Leu Ser Thr Ser Gly Ala Glu Leu Gln Arg Lys 
        115                 120                 125             


Glu Ser Leu Asp Ser Ile Ser His Ser Ser Gly Ser Glu Asp Ile Glu 
    130                 135                 140                 


Val His His Ser Gly His Lys Ile Arg Arg Asn Gln Lys Leu Thr Ala 
145                 150                 155                 160 


Ser Ser Leu Ser Leu Asp Thr Ala Ser Ser Ser Gln Leu Ser Cys Ser 
                165                 170                 175     


Leu Asn Ser Asp Ser Cys Leu Leu Gln Glu Asn Gly Ser Lys Ser Pro 
            180                 185                 190         


Asp His Cys Glu Glu Pro Met Ser Cys Asp Ser Asp Leu Gly Thr Ala 
        195                 200                 205             


Asn Ala Glu Asp Ser Asp Arg Ser Leu Gln Glu Val Leu Leu Glu Phe 
    210                 215                 220                 


Ser Lys Ala Gln Val Asn Ser Val Pro Thr Asn Gly Leu Ser Gln Glu 
225                 230                 235                 240 


Thr Glu Ile Pro Thr Pro Gln Ala Ser Leu Ser Leu His Gly Leu Asn 
                245                 250                 255     


Thr Ser Thr Tyr Leu His Cys Glu Ala Pro Ala Glu Pro Leu Pro Ala 
            260                 265                 270         


Gln Ala Ala Ser Gly Thr Gln Asp Gly Val His Val Gln Glu Pro Arg 
        275                 280                 285             


Pro Gln Ala Pro Ser Pro Leu Asp Leu Gln Gln Pro Val Glu Ser Thr 
    290                 295                 300                 


Ser Gly Gln Gln Pro Ser Ser Thr Val Ser Glu Thr Ala Arg Glu Val 
305                 310                 315                 320 


Gly Gln Gly Asn Gly Leu Gln Lys Ala Gln Ala His Asp Gly Ala Gly 
                325                 330                 335     


Leu Lys Leu Val Val Ser Ser Pro Thr Ser Pro Lys Asn Lys Ser Trp 
            340                 345                 350         


Ile Ser Glu Asp Asp Phe Tyr Arg Pro Ser Arg Glu Gln Pro Leu Glu 
        355                 360                 365             


Ser Ala Ser Asp His Pro Ile Ala Ser Tyr Arg Gly Thr Pro Gly Ser 
    370                 375                 380                 


Arg Pro Gly Leu His Arg His Phe Ser Gln Glu Pro Arg Lys Asn Cys 
385                 390                 395                 400 


Ser Leu Gly Ala Leu Asp Gln Ala Cys Val Pro Ser Pro Gly Arg Arg 
                405                 410                 415     


Gln Ala Gln Ala Ala Pro Ser Gln Gly His Lys Ser Phe Arg Val Val 
            420                 425                 430         


His Arg Arg Gln Met Gly Leu Ser Asn Pro Phe Arg Gly Leu Met Lys 
        435                 440                 445             


Leu Gly Thr Val Glu Arg Arg Gly Ala Met Gly Ile Trp Lys Glu Leu 
    450                 455                 460                 


Phe Cys Glu Leu Ser Pro Leu Glu Phe Arg Leu Tyr Leu Ser Asn Glu 
465                 470                 475                 480 


Glu His Thr Cys Val Glu Asn Cys Ser Leu Leu Arg Cys Glu Ser Val 
                485                 490                 495     


Gly Pro Ala His Ser Asp Gly Arg Phe Glu Leu Val Phe Ser Gly Lys 
            500                 505                 510         


Lys Leu Ala Leu Arg Ala Ser Ser Gln Asp Glu Ala Glu Asp Trp Leu 
        515                 520                 525             


Asp Arg Val Arg Glu Ala Leu Gln Lys Val Arg Pro Gln Gln Glu Asp 
    530                 535                 540                 


Glu Trp Val Asn Val Gln Tyr Pro Asp Gln Pro Glu Glu Pro Pro Glu 
545                 550                 555                 560 


Ala Pro Gln Gly Cys Leu Ser Pro Ser Asp Leu Leu Ser Glu Pro Ala 
                565                 570                 575     


Ala Leu Gln Gly Thr Gln Phe Asp Trp Ser Ser Ala Gln Val Pro Glu 
            580                 585                 590         


Pro Asp Ala Ile Lys Glu Ser Leu Leu Tyr Leu Tyr Met Asp Arg Thr 
        595                 600                 605             


Trp Met Pro Tyr Ile Phe Ser Leu Ser Leu Glu Ala Leu Lys Cys Phe 
    610                 615                 620                 


Arg Ile Arg Asn Asn Glu Lys Met Leu Ser Asp Ser His Gly Val Glu 
625                 630                 635                 640 


Thr Ile Arg Asp Ile Leu Pro Asp Thr Ser Leu Gly Gly Pro Ser Phe 
                645                 650                 655     


Phe Lys Ile Ile Thr Ala Lys Ala Val Leu Lys Leu Gln Ala Gly Asn 
            660                 665                 670         


Ala Glu Glu Ala Ala Leu Trp Arg Asp Leu Val Arg Lys Val Leu Ala 
        675                 680                 685             


Ser Tyr Leu Glu Thr Ala Glu Glu Ala Val Thr Leu Gly Gly Ser Leu 
    690                 695                 700                 


Asp Glu Asn Cys Gln Glu Val Leu Lys Phe Ala Thr Arg Glu Asn Gly 
705                 710                 715                 720 


Phe Leu Leu Gln Tyr Leu Val Ala Ile Pro Met Glu Lys Gly Leu Asp 
                725                 730                 735     


Ser Gln Gly Cys Phe Cys Ala Gly Cys Ser Arg Gln Ile Gly Phe Ser 
            740                 745                 750         


Phe Val Arg Pro Lys Leu Cys Ala Phe Ser Gly Leu Tyr Tyr Cys Asp 
        755                 760                 765             


Ile Cys His Gln Asp Asp Ala Ser Val Ile Pro Ala Arg Ile Ile His 
    770                 775                 780                 


Asn Trp Asp Leu Thr Lys Arg Pro Ile Cys Arg Gln Ala Leu Lys Phe 
785                 790                 795                 800 


Leu Thr Gln Ile Arg Ala Gln Pro Leu Ile Asn Leu Gln Met Val Asn 
                805                 810                 815     


Ala Ser Leu Tyr Glu His Val Glu Arg Met His Leu Ile Gly Arg Arg 
            820                 825                 830         


Arg Glu Gln Leu Lys Leu Leu Gly Asp Tyr Leu Gly Leu Cys Arg Ser 
        835                 840                 845             


Gly Ala Leu Lys Glu Leu Ser Lys Arg Leu Asn His Arg Asn Tyr Leu 
    850                 855                 860                 


Leu Glu Ser Pro His Arg Phe Ser Val Ala Asp Leu Gln Gln Ile Ala 
865                 870                 875                 880 


Asp Gly Val Tyr Glu Gly Phe Leu Lys Ala Leu Ile Glu Phe Ala Ser 
                885                 890                 895     


Gln His Val Tyr His Cys Asp Leu Cys Thr Gln Arg Gly Phe Ile Cys 
            900                 905                 910         


Gln Ile Cys Gln His His Asp Ile Ile Phe Pro Phe Glu Phe Asp Thr 
        915                 920                 925             


Thr Val Arg Cys Ala Glu Cys Lys Thr Val Phe His Gln Ser Cys Gln 
    930                 935                 940                 


Ala Val Val Lys Lys Gly Cys Pro Arg Cys Ala Arg Arg Arg Lys Tyr 
945                 950                 955                 960 


Gln Glu Gln Asn Ile Phe Ala 
                965         


<210> 9026
<211> 481
<212> PRT
<213> Homo sapiens

<400> 9026
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Asn Leu Pro Asn His 
    290                 295                 300                 


Leu Val Ile Pro Thr Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 9027
<211> 153
<212> PRT
<213> Homo sapiens

<400> 9027
Met Ala Pro Gly Ser Arg Gly Glu Arg Ser Ser Phe Arg Ser Arg Arg 
1               5                   10                  15      


Gly Pro Gly Val Pro Ser Pro Gln Pro Asp Val Thr Met Leu Ser Arg 
            20                  25                  30          


Leu Leu Lys Glu His Gln Ala Lys Gln Asn Glu Arg Lys Glu Leu Gln 
        35                  40                  45              


Glu Lys Arg Arg Arg Glu Ala Ile Thr Ala Ala Thr Cys Leu Thr Glu 
    50                  55                  60                  


Ala Leu Val Asp His Leu Asn Val Gly Val Ala Gln Ala Tyr Met Asn 
65                  70                  75                  80  


Gln Arg Lys Leu Asp His Glu Val Lys Thr Leu Gln Val Gln Ala Ala 
                85                  90                  95      


Gln Phe Ala Lys Gln Thr Gly Gln Trp Ile Gly Met Val Glu Asn Phe 
            100                 105                 110         


Asn Gln Ala Leu Lys Glu Ile Gly Asp Val Glu Asn Trp Ala Arg Ser 
        115                 120                 125             


Ile Glu Leu Asp Met Arg Thr Ile Ala Thr Ala Leu Glu Tyr Val Tyr 
    130                 135                 140                 


Lys Gly Gln Leu Gln Ser Ala Pro Ser 
145                 150             


<210> 9028
<211> 436
<212> PRT
<213> Homo sapiens

<400> 9028
Met Leu Trp Asn Phe Lys Pro His Ala Arg Ala Tyr Arg Tyr Val Gly 
1               5                   10                  15      


His Lys Asp Val Val Thr Ser Val Gln Phe Ser Pro His Gly Asn Leu 
            20                  25                  30          


Leu Ala Ser Ala Ser Arg Asp Arg Thr Val Arg Leu Trp Ile Pro Asp 
        35                  40                  45              


Lys Arg Gly Lys Phe Ser Glu Phe Lys Ala His Thr Ala Pro Val Arg 
    50                  55                  60                  


Ser Val Asp Phe Ser Ala Asp Gly Gln Phe Leu Ala Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Lys Ser Ile Lys Val Trp Ser Met Tyr Arg Gln Arg Phe Leu Tyr 
                85                  90                  95      


Ser Leu Tyr Arg His Thr His Trp Val Arg Cys Ala Lys Phe Ser Pro 
            100                 105                 110         


Asp Gly Arg Leu Ile Val Ser Cys Ser Glu Asp Lys Thr Ile Lys Ile 
        115                 120                 125             


Trp Asp Thr Thr Asn Lys Gln Cys Val Asn Asn Phe Ser Asp Ser Val 
    130                 135                 140                 


Gly Phe Ala Asn Phe Val Asp Phe Asn Pro Ser Gly Thr Cys Ile Ala 
145                 150                 155                 160 


Ser Ala Gly Ser Asp Gln Thr Val Lys Val Trp Asp Val Arg Val Asn 
                165                 170                 175     


Lys Leu Leu Gln His Tyr Gln Val His Ser Gly Gly Val Asn Cys Ile 
            180                 185                 190         


Ser Phe His Pro Ser Gly Asn Tyr Leu Ile Thr Ala Ser Ser Asp Gly 
        195                 200                 205             


Thr Leu Lys Ile Leu Asp Leu Leu Glu Gly Arg Leu Ile Tyr Thr Leu 
    210                 215                 220                 


Gln Gly His Thr Gly Pro Val Phe Thr Val Ser Phe Ser Lys Gly Gly 
225                 230                 235                 240 


Glu Leu Phe Ala Ser Gly Gly Ala Asp Thr Gln Val Leu Leu Trp Arg 
                245                 250                 255     


Thr Asn Phe Asp Glu Leu His Cys Lys Gly Leu Thr Lys Arg Asn Leu 
            260                 265                 270         


Lys Arg Leu His Phe Asp Ser Pro Pro His Leu Leu Asp Ile Tyr Pro 
        275                 280                 285             


Arg Thr Pro His Pro His Glu Glu Lys Val Glu Thr Val Glu Ile Asn 
    290                 295                 300                 


Pro Lys Leu Glu Val Ile Asp Leu Gln Ile Ser Thr Pro Pro Val Met 
305                 310                 315                 320 


Asp Ile Leu Ser Phe Asp Ser Thr Thr Thr Thr Glu Thr Ser Gly Arg 
                325                 330                 335     


Thr Leu Pro Asp Lys Gly Glu Glu Ala Cys Gly Tyr Phe Leu Asn Pro 
            340                 345                 350         


Ser Leu Met Ser Pro Glu Cys Leu Pro Thr Thr Thr Lys Lys Lys Thr 
        355                 360                 365             


Glu Asp Met Ser Asp Leu Pro Cys Glu Ser Gln Arg Ser Ile Pro Leu 
    370                 375                 380                 


Ala Val Thr Asp Ala Leu Glu His Ile Met Glu Gln Leu Asn Val Leu 
385                 390                 395                 400 


Thr Gln Thr Val Ser Ile Leu Glu Gln Arg Leu Thr Leu Thr Glu Asp 
                405                 410                 415     


Lys Leu Lys Asp Cys Leu Glu Asn Gln Gln Lys Leu Phe Ser Ala Val 
            420                 425                 430         


Gln Gln Lys Ser 
        435     


<210> 9029
<211> 198
<212> PRT
<213> Homo sapiens

<400> 9029
Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210> 9030
<211> 198
<212> PRT
<213> Homo sapiens

<400> 9030
Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210> 9031
<211> 164
<212> PRT
<213> Homo sapiens

<400> 9031
Met Met Glu Gly Asn Gly Thr Glu Asn Ser Cys Ser Arg Thr Arg Gly 
1               5                   10                  15      


Trp Leu Gln Gln Asp Asn Asp Ala Lys Pro Trp Leu Trp Lys Phe Ser 
            20                  25                  30          


Asn Cys Phe Ser Arg Pro Glu Gln Thr Leu Pro His Ser Pro Gln Thr 
        35                  40                  45              


Lys Glu Tyr Met Glu Asn Lys Lys Val Ala Val Glu Leu Lys Asp Val 
    50                  55                  60                  


Pro Ser Pro Leu His Ala Gly Ser Lys Leu Phe Pro Ala Val Pro Leu 
65                  70                  75                  80  


Pro Asp Ile Arg Ser Leu Gln Gln Pro Lys Ile Gln Leu Ser Ser Val 
                85                  90                  95      


Pro Lys Val Ser Cys Cys Ala His Cys Pro Asn Glu Pro Ser Thr Ser 
            100                 105                 110         


Pro Met Arg Phe Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Ser Ser 
        115                 120                 125             


Leu Ile His Pro Gly Ala Leu Leu Asp Ser Gln Ser Thr Arg Thr Ile 
    130                 135                 140                 


Thr Cys Gln Val Gly Ser Gly Phe Ala Phe Gln Ser Ala Ser Ser Leu 
145                 150                 155                 160 


Gln Asn Ala Ser 
                


<210> 9032
<211> 284
<212> PRT
<213> Homo sapiens

<400> 9032
Met Leu Ser Val Val Glu Asn Gly Leu Asp Pro Gln Ala Ala Ile Pro 
1               5                   10                  15      


Val Ile Lys Lys Lys Leu Val Gly Ser Val Lys Ala Leu Gln Lys Gln 
            20                  25                  30          


Tyr Val Ser Leu Asp Thr Val Val Thr Ser Glu Asp Gly Asp Ala Asn 
        35                  40                  45              


Thr Met Cys Ser Ala Leu Glu Ala Val Phe Ile His Gly Leu His Ala 
    50                  55                  60                  


Lys His Ile Arg Ala Glu Ala Gly Gly Lys Arg Lys Lys Ser Ala His 
65                  70                  75                  80  


Gln Lys Pro Leu Pro Gln Pro Val Phe Trp Pro Leu Leu Lys Ala Val 
                85                  90                  95      


Thr His Lys His Ile Ile Ser Glu Leu Glu His Leu Thr Phe Val Asn 
            100                 105                 110         


Thr Asp Val Gly Arg Cys Arg Ala Trp Leu Arg Leu Ala Leu Asn Asp 
        115                 120                 125             


Gly Leu Met Glu Cys Tyr Leu Lys Leu Leu Leu Gln Glu Gln Ala Arg 
    130                 135                 140                 


Leu Gln Leu Gln Arg Lys Glu Ser Leu Asp Ser Ile Ser His Ser Ser 
145                 150                 155                 160 


Gly Ser Glu Asp Ile Glu Val His His Ser Gly His Lys Ile Arg Arg 
                165                 170                 175     


Asn Gln Lys Leu Thr Ala Ser Ser Leu Ser Leu Asp Thr Ala Ser Ser 
            180                 185                 190         


Ser Gln Leu Ser Cys Ser Leu Asn Ser Asp Ser Cys Leu Leu Gln Glu 
        195                 200                 205             


Asn Gly Ser Lys Ser Pro Asp His Cys Glu Glu Pro Met Ser Cys Asp 
    210                 215                 220                 


Ser Asp Leu Gly Thr Ala Asn Ala Glu Asp Ser Asp Arg Ser Leu Gln 
225                 230                 235                 240 


Asp Ile Lys Ile Phe Ser Trp Ala Gln Trp Leu Thr Pro Val Ile Pro 
                245                 250                 255     


Ala Leu Trp Glu Ala Glu Ala Gly Gly Ser Gln Arg Gln Gln Ile Glu 
            260                 265                 270         


Thr Phe Leu Ala Asn Thr Val Lys Pro His Leu Tyr 
        275                 280                 


<210> 9033
<211> 1093
<212> PRT
<213> Homo sapiens

<400> 9033
Met Gly Gly Lys Ala Trp Pro Arg Arg Ala Val Gly Thr Ala Gly Gly 
1               5                   10                  15      


Pro Cys Ala Glu Gln Ile Ser Ala Pro Phe Gln Thr Leu Leu Met Pro 
            20                  25                  30          


His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu Arg His 
        35                  40                  45              


Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser Glu Pro 
    50                  55                  60                  


His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln Lys Arg 
65                  70                  75                  80  


Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly Glu Ser 
                85                  90                  95      


Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu Leu Val 
            100                 105                 110         


Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val Ser Gly 
        115                 120                 125             


Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala Trp Tyr 
    130                 135                 140                 


Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln Ala Arg 
145                 150                 155                 160 


Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro Pro Pro 
                165                 170                 175     


Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val Ala Ile 
            180                 185                 190         


Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln Val Leu 
        195                 200                 205             


Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala Val Val 
    210                 215                 220                 


Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu Leu Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala Lys Gly 
                245                 250                 255     


Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu Asp Trp 
            260                 265                 270         


Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala Val Thr 
        275                 280                 285             


Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg Asn His 
    290                 295                 300                 


Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser Asp Ile 
305                 310                 315                 320 


Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg Leu Pro 
                325                 330                 335     


Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val Ala Phe 
            340                 345                 350         


Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr Thr Arg 
        355                 360                 365             


Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro Asp Asp 
    370                 375                 380                 


Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro Leu Met 
385                 390                 395                 400 


Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro His Val 
                405                 410                 415     


Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala Asp Ala 
            420                 425                 430         


Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile Ala Glu 
        435                 440                 445             


Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly Leu His 
    450                 455                 460                 


Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu Arg Gly 
465                 470                 475                 480 


Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile Cys Ser 
                485                 490                 495     


Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp Phe Val 
            500                 505                 510         


Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu Ser Gly 
        515                 520                 525             


Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln His Trp 
    530                 535                 540                 


Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp Trp Gly 
545                 550                 555                 560 


His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln Gly Glu 
                565                 570                 575     


Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg Glu Val 
            580                 585                 590         


Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu Glu Arg 
        595                 600                 605             


Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe Pro Phe 
    610                 615                 620                 


Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg Phe Tyr 
625                 630                 635                 640 


Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe Trp Val 
                645                 650                 655     


Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu Pro Phe 
            660                 665                 670         


Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly Arg Lys 
        675                 680                 685             


Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile Ile Ser 
    690                 695                 700                 


Gly Val Glu Met Gln Leu Leu Gln Glu Lys Leu Arg Ser Gly Asn Leu 
705                 710                 715                 720 


Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys Asp Phe 
                725                 730                 735     


Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Thr Leu 
            740                 745                 750         


Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val Ser Glu 
        755                 760                 765             


Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala Leu Arg 
    770                 775                 780                 


Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro Ala Glu 
785                 790                 795                 800 


Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser Arg Leu 
                805                 810                 815     


Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg Glu Leu 
            820                 825                 830         


Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn Leu Cys 
        835                 840                 845             


Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser Pro Arg 
    850                 855                 860                 


Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu Gly Leu 
865                 870                 875                 880 


Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu Trp Gln 
                885                 890                 895     


Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile Ser Val 
            900                 905                 910         


Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln Pro Glu 
        915                 920                 925             


Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val Leu Arg 
    930                 935                 940                 


Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg Val Leu 
945                 950                 955                 960 


Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala Phe Leu 
                965                 970                 975     


Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu Leu Pro 
            980                 985                 990         


Pro Gly Thr Ala Ala Pro Ser Gly  Trp Ala Gln Ala Pro  Leu Ser Asp 
        995                 1000                 1005             


Thr Ala  Gln Val Tyr Met Glu  Leu Gln Gly Leu Val  Asp Pro Gln 
    1010                 1015                 1020             


Ile Gln  Leu Pro Leu Leu Ala  Ala Arg Arg Tyr Lys  Leu Gln Lys 
    1025                 1030                 1035             


Gln Leu  Asp Ser Leu Thr Ala  Arg Thr Pro Ser Glu  Gly Glu Ala 
    1040                 1045                 1050             


Gly Thr  Gln Arg Gln Gln Lys  Leu Ser Ser Leu Gln  Leu Glu Leu 
    1055                 1060                 1065             


Ser Lys  Leu Asp Lys Ala Ala  Ser His Leu Arg Gln  Leu Met Asp 
    1070                 1075                 1080             


Glu Pro  Pro Ala Pro Gly Ser  Pro Glu Leu 
    1085                 1090             


<210> 9034
<211> 1206
<212> PRT
<213> Homo sapiens

<400> 9034
Met Thr Ser Ala Ala Glu Ile Lys Lys Pro Pro Val Ala Pro Lys Pro 
1               5                   10                  15      


Lys Phe Val Val Ala Asn Asn Lys Pro Ala Pro Pro Pro Ile Ala Pro 
            20                  25                  30          


Lys Pro Asp Ile Val Ile Ser Ser Val Pro Gln Ser Thr Lys Lys Met 
        35                  40                  45              


Lys Pro Ala Ile Ala Pro Lys Pro Lys Val Leu Lys Thr Ser Pro Val 
    50                  55                  60                  


Arg Glu Ile Gly Gln Ser Pro Ser Arg Lys Ile Met Leu Asn Leu Glu 
65                  70                  75                  80  


Gly His Lys Gln Glu Leu Ala Glu Ser Thr Asp Asn Phe Asn Cys Lys 
                85                  90                  95      


Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser Cys 
            100                 105                 110         


Ser Ser Glu Cys Ile His Lys Leu Gly His Arg Glu Asn Leu Cys Val 
        115                 120                 125             


Lys Gln Leu Val Leu Glu Pro Leu Glu Met Asn Glu Asn Leu Glu Asn 
    130                 135                 140                 


Ser Lys Ile Asp Glu Thr Leu Thr Ile Lys Thr Arg Ser Lys Cys Asp 
145                 150                 155                 160 


Leu Tyr Gly Glu Lys Ala Lys Asn Gln Gly Gly Val Val Leu Lys Ala 
                165                 170                 175     


Ser Val Leu Glu Glu Glu Leu Lys Asp Ala Leu Ile His Gln Met Pro 
            180                 185                 190         


Pro Phe Ile Ser Ala Gln Lys His Arg Pro Thr Asp Ser Pro Glu Met 
        195                 200                 205             


Asn Gly Gly Cys Asn Ser Asn Gly Gln Phe Arg Ile Glu Phe Ala Asp 
    210                 215                 220                 


Leu Ser Pro Ser Pro Ser Ser Phe Glu Lys Val Pro Asp His His Ser 
225                 230                 235                 240 


Cys His Leu Gln Leu Pro Ser Asp Glu Cys Glu His Phe Glu Thr Cys 
                245                 250                 255     


Gln Asp Asp Ser Glu Lys Ser Asn Asn Cys Phe Gln Ser Ser Glu Leu 
            260                 265                 270         


Glu Ala Leu Glu Asn Gly Lys Arg Ser Thr Leu Ile Ser Ser Asp Gly 
        275                 280                 285             


Val Ser Lys Lys Ser Glu Val Lys Asp Leu Gly Pro Leu Glu Ile His 
    290                 295                 300                 


Leu Val Pro Tyr Thr Pro Lys Phe Pro Thr Pro Lys Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Ala Arg Leu Leu Arg Gln Lys Cys Val Asp Thr Pro Ser Glu 
                325                 330                 335     


Ser Thr Glu Glu Pro Gly Asn Ser Asp Ser Ser Ser Ser Cys Leu Thr 
            340                 345                 350         


Glu Asn Ser Leu Lys Ile Asn Lys Ile Ser Val Leu His Gln Asn Val 
        355                 360                 365             


Leu Cys Lys Gln Glu Gln Val Asp Lys Met Lys Leu Gly Asn Lys Ser 
    370                 375                 380                 


Glu Leu Asn Met Glu Ser Asn Ser Asp Ala Gln Asp Leu Val Asn Ser 
385                 390                 395                 400 


Gln Lys Ala Met Cys Asn Glu Thr Thr Ser Phe Glu Lys Met Ala Pro 
                405                 410                 415     


Ser Phe Asp Lys Asp Ser Asn Leu Ser Ser Asp Ser Thr Thr Val Asp 
            420                 425                 430         


Gly Ser Ser Met Ser Leu Ala Val Asp Glu Gly Thr Gly Phe Ile Arg 
        435                 440                 445             


Cys Thr Val Ser Met Ser Leu Pro Lys Gln Leu Lys Leu Thr Cys Asn 
    450                 455                 460                 


Glu His Leu Gln Ser Gly Arg Asn Leu Gly Val Ser Ala Pro Gln Met 
465                 470                 475                 480 


Gln Lys Glu Ser Val Ile Lys Glu Glu Asn Ser Leu Arg Ile Val Pro 
                485                 490                 495     


Lys Lys Pro Gln Arg His Ser Leu Pro Ala Thr Gly Val Leu Lys Lys 
            500                 505                 510         


Ala Ala Ser Glu Glu Leu Leu Glu Lys Ser Ser Tyr Pro Ser Ser Glu 
        515                 520                 525             


Glu Lys Ser Ser Glu Lys Ser Leu Glu Arg Asn His Leu Gln His Leu 
    530                 535                 540                 


Cys Ala Gln Asn Arg Gly Val Ser Ser Ser Phe Asp Met Pro Lys Arg 
545                 550                 555                 560 


Ala Ser Glu Lys Pro Val Trp Lys Leu Pro His Pro Ile Leu Pro Phe 
                565                 570                 575     


Ser Gly Asn Pro Glu Phe Leu Lys Ser Val Thr Val Ser Ser Asn Ser 
            580                 585                 590         


Glu Pro Ser Thr Ala Leu Thr Lys Pro Arg Ala Lys Ser Leu Ser Ala 
        595                 600                 605             


Met Asp Val Glu Lys Cys Thr Lys Pro Cys Lys Asp Ser Thr Lys Lys 
    610                 615                 620                 


Asn Ser Phe Lys Lys Leu Leu Ser Met Lys Leu Ser Ile Cys Phe Met 
625                 630                 635                 640 


Lys Ser Asp Phe Gln Lys Phe Trp Ser Lys Ser Ser Gln Leu Gly Asp 
                645                 650                 655     


Thr Thr Thr Gly His Leu Ser Ser Gly Glu Gln Lys Gly Ile Glu Ser 
            660                 665                 670         


Asp Trp Gln Gly Leu Leu Val Gly Glu Glu Lys Arg Ser Lys Pro Ile 
        675                 680                 685             


Lys Ala Tyr Ser Thr Glu Asn Tyr Ser Leu Glu Ser Gln Lys Lys Arg 
    690                 695                 700                 


Lys Lys Ser Arg Gly Gln Thr Ser Ala Ala Asn Gly Leu Arg Ala Glu 
705                 710                 715                 720 


Ser Leu Asp Asp Gln Met Leu Ser Arg Glu Ser Ser Ser Gln Ala Pro 
                725                 730                 735     


Tyr Lys Ser Val Thr Ser Leu Cys Ala Pro Glu Tyr Glu Asn Ile Arg 
            740                 745                 750         


His Tyr Glu Glu Ile Pro Glu Tyr Glu Asn Leu Pro Phe Ile Met Ala 
        755                 760                 765             


Ile Arg Lys Thr Gln Glu Leu Glu Trp Gln Asn Ser Ser Ser Met Glu 
    770                 775                 780                 


Asp Ala Asp Ala Asn Val Tyr Glu Val Glu Glu Pro Tyr Glu Ala Pro 
785                 790                 795                 800 


Asp Gly Gln Leu Gln Leu Gly Pro Arg His Gln His Ser Ser Ser Gly 
                805                 810                 815     


Ala Ser Gln Glu Glu Gln Asn Asp Leu Gly Leu Gly Asp Leu Pro Ser 
            820                 825                 830         


Asp Glu Glu Glu Ile Ile Asn Ser Ser Asp Glu Asp Asp Val Ser Ser 
        835                 840                 845             


Glu Ser Ser Lys Gly Glu Pro Asp Pro Leu Glu Asp Lys Gln Asp Glu 
    850                 855                 860                 


Asp Asn Gly Met Lys Ser Lys Val His His Ile Ala Lys Glu Ile Met 
865                 870                 875                 880 


Ser Ser Glu Lys Val Phe Val Asp Val Leu Lys Leu Leu His Ile Asp 
                885                 890                 895     


Phe Arg Asp Ala Val Ala His Ala Ser Arg Gln Leu Gly Lys Pro Val 
            900                 905                 910         


Ile Glu Asp Arg Ile Leu Asn Gln Ile Leu Tyr Tyr Leu Pro Gln Leu 
        915                 920                 925             


Tyr Glu Leu Asn Arg Asp Leu Leu Lys Glu Leu Glu Glu Arg Met Leu 
    930                 935                 940                 


His Trp Thr Glu Gln Gln Arg Ile Ala Asp Ile Phe Val Lys Lys Gly 
945                 950                 955                 960 


Pro Tyr Leu Lys Met Tyr Ser Thr Tyr Ile Lys Glu Phe Asp Lys Asn 
                965                 970                 975     


Ile Ala Leu Leu Asp Glu Gln Cys Lys Lys Asn Pro Gly Phe Ala Ala 
            980                 985                 990         


Val Val Arg Glu Phe Glu Met Ser  Pro Arg Cys Ala Asn  Leu Ala Leu 
        995                 1000                 1005             


Lys His  Tyr Leu Leu Lys Pro  Val Gln Arg Ile Pro  Gln Tyr Arg 
    1010                 1015                 1020             


Leu Leu  Leu Thr Asp Tyr Leu  Lys Asn Leu Ile Glu  Asp Ala Gly 
    1025                 1030                 1035             


Asp Tyr  Arg Asp Thr Gln Asp  Ala Leu Ala Val Val  Ile Glu Val 
    1040                 1045                 1050             


Ala Asn  His Ala Asn Asp Thr  Met Lys Gln Gly Asp  Asn Phe Gln 
    1055                 1060                 1065             


Lys Leu  Met Gln Ile Gln Tyr  Ser Leu Asn Gly His  His Glu Ile 
    1070                 1075                 1080             


Val Gln  Pro Gly Arg Val Phe  Leu Lys Glu Gly Ile  Leu Met Lys 
    1085                 1090                 1095             


Leu Ser  Arg Lys Val Met Gln  Pro Arg Met Phe Phe  Leu Phe Asn 
    1100                 1105                 1110             


Asp Ala  Leu Leu Tyr Thr Thr  Pro Val Gln Ser Gly  Met Tyr Lys 
    1115                 1120                 1125             


Leu Asn  Asn Met Leu Ser Leu  Ala Gly Met Lys Val  Arg Lys Pro 
    1130                 1135                 1140             


Thr Gln  Glu Ala Tyr Gln Asn  Glu Leu Lys Ile Glu  Ser Val Glu 
    1145                 1150                 1155             


Arg Ser  Phe Ile Leu Ser Ala  Ser Ser Ala Thr Glu  Arg Asp Glu 
    1160                 1165                 1170             


Trp Leu  Glu Ala Ile Ser Arg  Ala Ile Glu Glu Tyr  Ala Lys Lys 
    1175                 1180                 1185             


Arg Ile  Thr Phe Cys Pro Ser  Arg Ser Leu Asp Glu  Ala Asp Ser 
    1190                 1195                 1200             


Glu Asn  Lys 
    1205     


<210> 9035
<211> 144
<212> PRT
<213> Homo sapiens

<400> 9035
Met Asp Lys Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser 
1               5                   10                  15      


Gly Thr Ala Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys 
            20                  25                  30          


Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser 
        35                  40                  45              


Ser Arg Thr Leu Tyr Arg Phe Ile Lys Arg Lys Lys Phe Asp Asp Glu 
    50                  55                  60                  


Leu Val Glu Ser Ser Leu Ala Lys Ser Ser Thr Arg Ala Lys Gly Ala 
65                  70                  75                  80  


Ser Gly Val Glu Pro Gly Arg Cys Ser Gly Ser Glu Pro Ser Ser Ser 
                85                  90                  95      


Glu Lys Lys Lys Val Ser Lys Ala Pro Ser Thr Pro Val Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Ala Pro Gly Leu Thr Lys Arg Val Lys Lys Ser Lys Gln 
        115                 120                 125             


Pro Leu Gln Val Thr Lys Asp Leu Gly Arg Trp Lys Pro Ala Asp Asp 
    130                 135                 140                 


<210> 9036
<211> 269
<212> PRT
<213> Homo sapiens

<400> 9036
Met Lys Thr Pro Val Glu Leu Ala Val Ser Gly Met Gln Thr Leu Gly 
1               5                   10                  15      


Leu Gln His Arg Cys Arg Gly Gly Tyr Arg Val Lys Ala Arg Thr Ser 
            20                  25                  30          


Tyr Val Asp Glu Thr Leu Phe Gly Ser Pro Ala Gly Thr Arg Pro Thr 
        35                  40                  45              


Pro Pro Asp Phe Asp Pro Pro Trp Val Glu Lys Ala Asn Arg Thr Arg 
    50                  55                  60                  


Gly Val Gly Lys Glu Ala Ser Lys Ala Leu Gly Ala Lys Gly Ser Cys 
65                  70                  75                  80  


Glu Thr Thr Pro Ser Arg Gly Ser Thr Pro Thr Leu Thr Pro Arg Lys 
                85                  90                  95      


Lys Asn Lys Tyr Arg Pro Ile Ser His Thr Pro Ser Tyr Cys Asp Glu 
            100                 105                 110         


Ser Leu Phe Gly Ser Arg Ser Glu Gly Ala Ser Phe Gly Ala Pro Arg 
        115                 120                 125             


Met Ala Lys Gly Asp Ala Ala Lys Leu Arg Ala Leu Leu Trp Thr Pro 
    130                 135                 140                 


Pro Pro Thr Pro Arg Gly Ser His Ser Pro Arg Pro Arg Glu Ala Pro 
145                 150                 155                 160 


Leu Arg Ala Ile His Pro Ala Gly Pro Ser Lys Thr Glu Pro Gly Pro 
                165                 170                 175     


Ala Ala Asp Ser Gln Lys Leu Ser Met Gly Gly Leu His Ser Ser Arg 
            180                 185                 190         


Pro Leu Lys Arg Gly Leu Ser His Ser Leu Thr His Leu Asn Val Pro 
        195                 200                 205             


Ser Thr Gly His Pro Ala Thr Ser Ala Pro His Thr Asn Gly Pro Gln 
    210                 215                 220                 


Asp Leu Arg Pro Ser Thr Ser Gly Val Thr Phe Arg Ser Pro Leu Val 
225                 230                 235                 240 


Thr Ser Arg Ala Arg Ser Val Ser Ile Ser Val Pro Ser Thr Pro Arg 
                245                 250                 255     


Arg Gly Gly Ala Thr Gln Lys Pro Lys Pro Pro Trp Lys 
            260                 265                 


<210> 9037
<211> 166
<212> PRT
<213> Homo sapiens

<400> 9037
Met Ala Asn Asp Pro Leu Glu Gly Phe His Glu Val Asn Leu Ala Ser 
1               5                   10                  15      


Pro Thr Ser Pro Asp Leu Leu Gly Val Tyr Glu Ser Gly Thr Gln Glu 
            20                  25                  30          


Gln Thr Thr Ser Pro Ser Val Ile Tyr Arg Pro His Pro Ser Ala Leu 
        35                  40                  45              


Ser Ser Val Pro Ile Gln Ala Asn Ala Leu Asp Val Ser Glu Leu Pro 
    50                  55                  60                  


Thr Gln Pro Val Tyr Ser Ser Pro Arg Arg Leu Asn Cys Ala Glu Ile 
65                  70                  75                  80  


Ser Ser Ile Ser Phe His Val Thr Asp Pro Ala Pro Cys Ser Thr Ser 
                85                  90                  95      


Gly Val Thr Ala Gly Leu Thr Lys Leu Thr Thr Arg Lys Asp Asn Tyr 
            100                 105                 110         


Asn Ala Glu Arg Glu Phe Leu Gln Gly Ala Thr Ile Thr Glu Ala Cys 
        115                 120                 125             


Asp Gly Ser Asp Asp Ile Phe Gly Leu Ser Thr Asp Ser Leu Ser Arg 
    130                 135                 140                 


Leu Arg Ser Pro Ser Val Leu Glu Val Arg Glu Lys Gly Tyr Glu Arg 
145                 150                 155                 160 


Leu Lys Glu Glu Leu Ala 
                165     


<210> 9038
<211> 129
<212> PRT
<213> Homo sapiens

<400> 9038
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn 
    


<210> 9039
<211> 161
<212> PRT
<213> Homo sapiens

<400> 9039
Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro 
    


<210> 9040
<211> 462
<212> PRT
<213> Homo sapiens

<400> 9040
Met Asp Lys Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser 
1               5                   10                  15      


Gly Thr Ala Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys 
            20                  25                  30          


Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser 
        35                  40                  45              


Ser Arg Phe Ile Lys Arg Lys Lys Phe Asp Asp Glu Leu Val Glu Ser 
    50                  55                  60                  


Ser Leu Ala Lys Ser Ser Thr Arg Ala Lys Gly Ala Ser Gly Val Glu 
65                  70                  75                  80  


Pro Gly Arg Cys Ser Gly Ser Glu Pro Ser Ser Ser Glu Lys Lys Lys 
                85                  90                  95      


Val Ser Lys Ala Pro Ser Thr Pro Val Pro Pro Ser Pro Ala Pro Ala 
            100                 105                 110         


Pro Gly Leu Thr Lys Arg Val Lys Lys Ser Lys Gln Pro Leu Gln Val 
        115                 120                 125             


Thr Lys Asp Leu Gly Arg Trp Lys Pro Ala Asp Asp Leu Leu Leu Ile 
    130                 135                 140                 


Asn Ala Val Leu Gln Thr Asn Asp Leu Thr Ser Val His Leu Gly Val 
145                 150                 155                 160 


Lys Phe Ser Cys Arg Phe Thr Leu Arg Glu Val Gln Glu Arg Trp Tyr 
                165                 170                 175     


Ala Leu Leu Tyr Asp Pro Val Ile Ser Lys Leu Ala Cys Gln Ala Met 
            180                 185                 190         


Arg Gln Leu His Pro Glu Ala Ile Ala Ala Ile Gln Ser Lys Ala Leu 
        195                 200                 205             


Phe Ser Lys Ala Glu Glu Gln Leu Leu Ser Lys Val Gly Ser Thr Ser 
    210                 215                 220                 


Gln Pro Thr Leu Glu Thr Phe Gln Asp Leu Leu His Arg His Pro Asp 
225                 230                 235                 240 


Ala Phe Tyr Leu Ala Arg Thr Ala Lys Ala Leu Gln Ala His Trp Gln 
                245                 250                 255     


Leu Met Lys Gln Tyr Tyr Leu Leu Glu Asp Gln Thr Val Gln Pro Leu 
            260                 265                 270         


Pro Lys Gly Asp Gln Val Leu Asn Phe Ser Asp Ala Glu Asp Leu Ile 
        275                 280                 285             


Asp Asp Ser Lys Leu Lys Asp Met Arg Asp Glu Val Leu Glu His Glu 
    290                 295                 300                 


Leu Met Val Ala Asp Arg Arg Gln Lys Arg Glu Ile Arg Gln Leu Glu 
305                 310                 315                 320 


Gln Glu Leu His Lys Trp Gln Val Leu Val Asp Ser Ile Thr Gly Met 
                325                 330                 335     


Ser Ser Pro Asp Phe Asp Asn Gln Thr Leu Ala Val Leu Arg Gly Arg 
            340                 345                 350         


Met Val Arg Tyr Leu Met Arg Ser Arg Glu Ile Thr Leu Gly Arg Ala 
        355                 360                 365             


Thr Lys Asp Asn Gln Ile Asp Val Asp Leu Ser Leu Glu Gly Pro Ala 
    370                 375                 380                 


Trp Lys Ile Ser Arg Lys Gln Gly Val Ile Lys Leu Lys Asn Asn Gly 
385                 390                 395                 400 


Asp Phe Phe Ile Ala Asn Glu Gly Arg Arg Pro Ile Tyr Ile Asp Gly 
                405                 410                 415     


Arg Pro Val Leu Cys Gly Ser Lys Trp Arg Leu Ser Asn Asn Ser Val 
            420                 425                 430         


Val Glu Ile Ala Ser Leu Arg Phe Val Phe Leu Ile Asn Gln Asp Leu 
        435                 440                 445             


Ile Ala Leu Ile Arg Ala Glu Ala Ala Lys Ile Thr Pro Gln 
    450                 455                 460         


<210> 9041
<211> 191
<212> PRT
<213> Homo sapiens

<400> 9041
Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Ile Ala Arg Gly Phe Glu Arg Gly Leu Glu Pro Glu Lys Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Cys Gly Asp Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Thr Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Val Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ala 
                165                 170                 175     


Tyr Pro Glu Asp Ala Glu Asn Lys Glu Lys Glu Thr Ala Lys Ser 
            180                 185                 190     


<210> 9042
<211> 403
<212> PRT
<213> Homo sapiens

<400> 9042
Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg Asp Arg 
                85                  90                  95      


Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg Asn Pro 
            100                 105                 110         


Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser Tyr Asp 
        115                 120                 125             


Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala Asp Met 
    130                 135                 140                 


His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys His Gly 
145                 150                 155                 160 


Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser Val Asp 
                165                 170                 175     


Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser His Arg 
            180                 185                 190         


Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val Ser Arg 
        195                 200                 205             


Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu Lys Asp 
    210                 215                 220                 


Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu Glu Glu 
225                 230                 235                 240 


Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe Leu Val 
                245                 250                 255     


Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His Asp Ile 
            260                 265                 270         


Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu Asp Glu 
        275                 280                 285             


Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala Leu Val 
    290                 295                 300                 


Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile His Ser 
305                 310                 315                 320 


His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp Val Tyr 
                325                 330                 335     


Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr Phe Met 
            340                 345                 350         


Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys Ala Ala 
        355                 360                 365             


His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr 
    370                 375                 380                 


Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile Thr Asn 
385                 390                 395                 400 


Ile Phe Ala 
            


<210> 9043
<211> 191
<212> PRT
<213> Homo sapiens

<400> 9043
Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys 
1               5                   10                  15      


Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp Lys 
            20                  25                  30          


Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu Val 
        35                  40                  45              


Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln 
    50                  55                  60                  


Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg 
                85                  90                  95      


Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly 
            100                 105                 110         


Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly 
        115                 120                 125             


Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe 
    130                 135                 140                 


Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr 
145                 150                 155                 160 


Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr 
                165                 170                 175     


Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
            180                 185                 190     


<210> 9044
<211> 180
<212> PRT
<213> Homo sapiens

<400> 9044
Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys 
            180 


<210> 9045
<211> 476
<212> PRT
<213> Homo sapiens

<400> 9045
Met Gly Leu Lys Lys Met Lys Gly Leu Ser Tyr Asp Glu Ala Phe Ala 
1               5                   10                  15      


Met Ala Asn Asp Pro Leu Glu Gly Phe His Glu Val Asn Leu Ala Ser 
            20                  25                  30          


Pro Thr Ser Pro Asp Leu Leu Gly Val Tyr Glu Ser Gly Thr Gln Glu 
        35                  40                  45              


Gln Thr Thr Ser Pro Ser Val Ile Tyr Arg Pro His Pro Ser Ala Leu 
    50                  55                  60                  


Ser Ser Val Pro Ile Gln Ala Asn Ala Leu Asp Val Ser Glu Leu Pro 
65                  70                  75                  80  


Thr Gln Pro Val Tyr Ser Ser Pro Arg Arg Leu Asn Cys Ala Glu Ile 
                85                  90                  95      


Ser Ser Ile Ser Phe His Val Thr Asp Pro Ala Pro Cys Ser Thr Ser 
            100                 105                 110         


Gly Val Thr Ala Gly Leu Thr Lys Leu Thr Thr Arg Lys Asp Asn Tyr 
        115                 120                 125             


Asn Ala Glu Arg Glu Phe Leu Gln Gly Ala Thr Ile Thr Glu Ala Cys 
    130                 135                 140                 


Asp Gly Ser Asp Asp Ile Phe Gly Leu Ser Thr Asp Ser Leu Ser Arg 
145                 150                 155                 160 


Leu Arg Ser Pro Ser Val Leu Glu Val Arg Glu Lys Gly Tyr Glu Arg 
                165                 170                 175     


Leu Lys Glu Glu Leu Ala Lys Ala Gln Arg Glu Leu Lys Leu Lys Asp 
            180                 185                 190         


Glu Glu Cys Glu Arg Leu Ser Lys Val Arg Asp Gln Leu Gly Gln Glu 
        195                 200                 205             


Leu Glu Glu Leu Thr Ala Ser Leu Phe Glu Glu Ala His Lys Met Val 
    210                 215                 220                 


Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu Lys Glu 
225                 230                 235                 240 


Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala Leu Lys 
                245                 250                 255     


Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu Pro Leu 
            260                 265                 270         


Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn Lys Ser 
        275                 280                 285             


Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val Ile Gln 
    290                 295                 300                 


Pro Ile Val Lys Asp Cys Lys Glu Ala Asp Leu Ser Leu Tyr Asn Glu 
305                 310                 315                 320 


Phe Arg Leu Trp Lys Asp Glu Pro Thr Met Asp Arg Thr Cys Pro Phe 
                325                 330                 335     


Leu Asp Lys Ile Tyr Gln Glu Asp Ile Phe Pro Cys Leu Thr Phe Ser 
            340                 345                 350         


Lys Ser Glu Leu Ala Ser Ala Val Leu Glu Ala Val Glu Asn Asn Thr 
        355                 360                 365             


Leu Ser Ile Glu Pro Val Gly Leu Gln Pro Ile Arg Phe Val Lys Ala 
    370                 375                 380                 


Ser Ala Val Glu Cys Gly Gly Pro Lys Lys Cys Ala Leu Thr Gly Gln 
385                 390                 395                 400 


Ser Lys Ser Cys Lys His Arg Ile Lys Leu Gly Asp Ser Ser Asn Tyr 
                405                 410                 415     


Tyr Tyr Ile Ser Pro Phe Cys Arg Tyr Arg Ile Thr Ser Val Cys Asn 
            420                 425                 430         


Phe Phe Thr Tyr Ile Arg Tyr Ile Gln Gln Gly Leu Val Lys Gln Gln 
        435                 440                 445             


Asp Val Asp Gln Met Phe Trp Glu Val Met Gln Leu Arg Lys Glu Met 
    450                 455                 460                 


Ser Leu Ala Lys Leu Gly Tyr Phe Lys Glu Glu Leu 
465                 470                 475     


<210> 9046
<211> 111
<212> PRT
<213> Homo sapiens

<400> 9046
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr 
            100                 105                 110     


<210> 9047
<211> 107
<212> PRT
<213> Homo sapiens

<400> 9047
Met Ile Lys Asn Leu Glu Val Gln Leu Arg Arg Ala Thr Asp Glu Met 
1               5                   10                  15      


Lys Ala Tyr Ile Ser Ser Asp Gln Gln Glu Lys Arg Lys Ala Ile Arg 
            20                  25                  30          


Glu Gln Tyr Thr Lys Asn Thr Ala Glu Gln Glu Asn Leu Gly Lys Lys 
        35                  40                  45              


Leu Arg Glu Lys Gln Lys Val Ile Arg Glu Ser His Gly Pro Asn Met 
    50                  55                  60                  


Lys Gln Ala Lys Met Trp Arg Asp Leu Glu Gln Leu Met Glu Cys Lys 
65                  70                  75                  80  


Lys Gln Cys Phe Leu Lys Gln Gln Ser Gln Thr Ser Ile Gly Gln Val 
                85                  90                  95      


Ile Gln Glu Gly Gly Glu Asp Arg Leu Ile Leu 
            100                 105         


<210> 9048
<211> 923
<212> PRT
<213> Homo sapiens

<400> 9048
Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His 
1               5                   10                  15      


Ala Leu Thr Val Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met 
            20                  25                  30          


Arg Gly Asp Gln Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile 
        35                  40                  45              


Ala Thr Gln Ala Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val 
    50                  55                  60                  


Arg Arg His Glu Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln 
65                  70                  75                  80  


Trp Lys Glu Ala Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu 
                85                  90                  95      


Gly Ala Ser Leu Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly 
            100                 105                 110         


Ser Ser Val Ala Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly 
        115                 120                 125             


Leu Leu Tyr Arg Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg 
    130                 135                 140                 


Ser Ala Ile Ser Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His 
145                 150                 155                 160 


Thr Gln Leu Arg Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu 
                165                 170                 175     


Leu Phe Ser Val Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val 
            180                 185                 190         


Val Val Gly Thr Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val 
        195                 200                 205             


Ala Val His Pro Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln 
    210                 215                 220                 


Leu Arg His Pro Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr 
225                 230                 235                 240 


Ala Val Gln Pro His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala 
                245                 250                 255     


His Ser Pro Ala Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro 
            260                 265                 270         


Leu Asn Val Ile Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp 
        275                 280                 285             


Trp Leu Gln Gly Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser 
    290                 295                 300                 


Val Leu Ser Glu Arg Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met 
305                 310                 315                 320 


Val Leu Pro Ile Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu 
                325                 330                 335     


Lys Asn Gln Trp Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala 
            340                 345                 350         


Lys Ala Val Glu Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln 
        355                 360                 365             


Lys Asn Trp Gln His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser 
    370                 375                 380                 


Arg Gln Leu Trp Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu 
385                 390                 395                 400 


Asp His Ala Gln Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu 
                405                 410                 415     


Ala Glu Ala Arg Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala 
            420                 425                 430         


Glu Leu Thr Leu Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser 
        435                 440                 445             


Ser Ala Leu Phe Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro 
    450                 455                 460                 


Asp Leu Ala Arg Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp 
465                 470                 475                 480 


Leu Leu Leu Phe Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu 
                485                 490                 495     


Thr Gly Gln Leu Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg 
            500                 505                 510         


Asp Arg Gln Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp 
        515                 520                 525             


Pro Arg Asp Ile Ile Ser Gly Val Glu Met Gln Leu Leu Gln Glu Lys 
    530                 535                 540                 


Leu Arg Ser Gly Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala 
545                 550                 555                 560 


Ala Gln Lys Lys Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp 
                565                 570                 575     


Ala Leu Arg Phe Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu 
            580                 585                 590         


His Leu Ser Val Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys 
        595                 600                 605             


Ile Trp Asn Ala Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe 
    610                 615                 620                 


Val Pro Gln Pro Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala 
625                 630                 635                 640 


Trp Ile Leu Ser Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly 
                645                 650                 655     


Phe Leu Thr Arg Glu Leu Ser Leu Val Thr His Ala Leu His His Phe 
            660                 665                 670         


Trp Leu His Asn Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val 
        675                 680                 685             


Leu Trp His Ser Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser 
    690                 695                 700                 


Cys Ala Asp Leu Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu 
705                 710                 715                 720 


Ala Glu Glu Leu Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro 
                725                 730                 735     


Ala Pro Ser Ile Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu 
            740                 745                 750         


His Trp Arg Gln Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu 
        755                 760                 765             


Val Val Gln Val Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys 
    770                 775                 780                 


Ala Arg Pro Arg Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly 
785                 790                 795                 800 


Leu Phe Glu Ala Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly 
                805                 810                 815     


Ala Val Gly Leu Leu Pro Pro Gly Thr Ala Ala Pro Ser Gly Trp Ala 
            820                 825                 830         


Gln Ala Pro Leu Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly 
        835                 840                 845             


Leu Val Asp Pro Gln Ile Gln Leu Pro Leu Leu Ala Ala Arg Arg Tyr 
    850                 855                 860                 


Lys Leu Gln Lys Gln Leu Asp Ser Leu Thr Ala Arg Thr Pro Ser Glu 
865                 870                 875                 880 


Gly Glu Ala Gly Thr Gln Arg Gln Gln Lys Leu Ser Ser Leu Gln Leu 
                885                 890                 895     


Glu Leu Ser Lys Leu Asp Lys Ala Ala Ser His Leu Arg Gln Leu Met 
            900                 905                 910         


Asp Glu Pro Pro Ala Pro Gly Ser Pro Glu Leu 
        915                 920             


<210> 9049
<211> 691
<212> PRT
<213> Homo sapiens

<400> 9049
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Thr Tyr Ile Pro Asn Thr Lys Val Glu Cys 
            20                  25                  30          


His Tyr Thr Leu Pro Pro Gly Thr Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Thr Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Thr Thr Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Thr Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Thr Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Thr Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Thr Glu 
                165                 170                 175     


Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Thr Ala Arg 
            180                 185                 190         


Gln Glu His Thr Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser 
        195                 200                 205             


His Gly Glu Ile Thr Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly 
    210                 215                 220                 


Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Thr Ile 
225                 230                 235                 240 


Ser Glu Lys Val Leu Thr Lys Glu Val Glu Leu Asp Arg Leu Arg Asp 
                245                 250                 255     


Thr Val Lys Ala Leu Thr Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu 
            260                 265                 270         


Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Gln Val 
        275                 280                 285             


Ala Gln Gln Glu Asn His His Leu Asn Leu Asp Leu Lys Glu Ala Lys 
    290                 295                 300                 


Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln Arg Leu Lys Asp Lys 
305                 310                 315                 320 


Val Ala Gln Met Lys Asp Thr Leu Gly Gln Ala Gln Gln Arg Val Ala 
                325                 330                 335     


Glu Leu Glu Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala 
            340                 345                 350         


Ala Ser Ser Gln Gln Lys Ala Thr Leu Leu Gly Glu Glu Leu Ala Ser 
        355                 360                 365             


Ala Ala Ala Ala Arg Asp Arg Thr Ile Ala Glu Leu His Arg Ser Arg 
    370                 375                 380                 


Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His 
385                 390                 395                 400 


Leu Lys Glu Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu 
                405                 410                 415     


Gln Ser Val Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu 
            420                 425                 430         


Ile Leu Arg Leu Glu Lys Ala Val Gln Glu Glu Arg Thr Gln Asn Gln 
        435                 440                 445             


Val Phe Lys Thr Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln 
    450                 455                 460                 


Leu Ser Glu Ser Lys Arg Glu Leu Thr Glu Leu Arg Ser Ala Leu Arg 
465                 470                 475                 480 


Val Leu Gln Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu 
                485                 490                 495     


Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp 
            500                 505                 510         


Glu Lys Trp Asn Glu Asp Ala Thr Thr Glu Asp Glu Glu Ala Ala Val 
        515                 520                 525             


Gly Leu Ser Cys Pro Ala Ala Leu Thr Asp Ser Glu Asp Glu Ser Pro 
    530                 535                 540                 


Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro 
545                 550                 555                 560 


Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile 
                565                 570                 575     


Ser Gln Pro Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp 
            580                 585                 590         


Ser Ser Ser Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala 
        595                 600                 605             


Ala Val Gln Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu 
    610                 615                 620                 


Gly Ser Ala Phe Tyr Asp Met Ala Ser Gly Phe Thr Val Gly Thr Leu 
625                 630                 635                 640 


Ser Glu Thr Ser Thr Gly Gly Pro Ala Thr Pro Thr Trp Lys Glu Cys 
                645                 650                 655     


Pro Ile Cys Lys Glu Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala Leu 
            660                 665                 670         


Glu Asp His Met Asp Gly His Phe Phe Phe Ser Thr Gln Asp Pro Phe 
        675                 680                 685             


Thr Phe Glu 
    690     


<210> 9050
<211> 121
<212> PRT
<213> Homo sapiens

<400> 9050
Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala 
        115                 120     


<210> 9051
<211> 218
<212> PRT
<213> Homo sapiens

<400> 9051
Met Asn Cys Arg Ser Glu Val Leu Glu Val Ser Val Glu Gly Arg Gln 
1               5                   10                  15      


Val Glu Glu Ala Met Leu Ala Val Leu His Thr Val Leu Leu His Arg 
            20                  25                  30          


Ser Thr Gly Lys Phe His Tyr Lys Lys Glu Gly Thr Tyr Ser Ile Gly 
        35                  40                  45              


Thr Val Gly Thr Gln Asp Val Asp Cys Asp Phe Ile Asp Phe Thr Tyr 
    50                  55                  60                  


Val Arg Val Ser Ser Glu Glu Leu Asp Arg Ala Leu Arg Lys Val Val 
65                  70                  75                  80  


Gly Glu Phe Lys Asp Ala Leu Arg Asn Ser Gly Gly Asp Gly Leu Gly 
                85                  90                  95      


Gln Met Ser Leu Glu Phe Tyr Gln Lys Lys Lys Ser Arg Trp Pro Phe 
            100                 105                 110         


Ser Asp Glu Cys Ile Pro Trp Glu Val Trp Thr Val Lys Val His Val 
        115                 120                 125             


Val Ala Leu Ala Thr Glu Gln Glu Arg Gln Ile Cys Arg Glu Lys Val 
    130                 135                 140                 


Gly Glu Lys Leu Cys Glu Lys Ile Ile Asn Ile Val Glu Val Met Asn 
145                 150                 155                 160 


Arg His Glu Tyr Leu Pro Lys Met Pro Thr Gln Ser Glu Val Asp Asn 
                165                 170                 175     


Val Phe Asp Thr Gly Leu Arg Asp Val Gln Pro Tyr Leu Tyr Lys Ile 
            180                 185                 190         


Ser Phe Gln Ile Thr Asp Ala Leu Gly Thr Ser Val Thr Thr Thr Met 
        195                 200                 205             


Arg Arg Leu Ile Lys Asp Thr Leu Ala Leu 
    210                 215             


<210> 9052
<211> 632
<212> PRT
<213> Homo sapiens

<400> 9052
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                165                 170                 175     


Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
            180                 185                 190         


Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
        195                 200                 205             


Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
    210                 215                 220                 


Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
225                 230                 235                 240 


Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                245                 250                 255     


Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
            260                 265                 270         


Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
        275                 280                 285             


Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys Gly 
    290                 295                 300                 


Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys Arg 
305                 310                 315                 320 


Val Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys Ile 
                325                 330                 335     


Pro Thr Leu Ile Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu Ala 
            340                 345                 350         


Asp Phe Val Ser Gln Thr Ser Pro Met Ile Pro Ser Ile Val Val His 
        355                 360                 365             


Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Thr Gly Leu Tyr 
    370                 375                 380                 


Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys Phe 
385                 390                 395                 400 


Leu Arg Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile His 
                405                 410                 415     


Ala Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu Pro 
            420                 425                 430         


Leu Leu Thr Phe Arg Leu Asn Arg Ala Phe Met Glu Ala Ala Glu Ile 
        435                 440                 445             


Thr Asp Glu Asp Asn Ser Ile Ala Ala Met Tyr Gln Ala Val Gly Glu 
    450                 455                 460                 


Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His Leu 
465                 470                 475                 480 


Gln Arg Val Ala Gln Ser Pro His Thr Lys Met Asp Val Ala Asn Leu 
                485                 490                 495     


Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Ala Val Pro Asn Pro 
            500                 505                 510         


Asp Pro Val Thr Met Leu Gln Asp Ile Lys Arg Gln Pro Lys Val Val 
        515                 520                 525             


Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Ser Gln Phe Met Met 
    530                 535                 540                 


Val Glu Gln Glu Asn Ile Asp Pro Leu His Val Ile Glu Asn Ser Asn 
545                 550                 555                 560 


Ala Phe Ser Thr Pro Gln Thr Pro Asp Ile Lys Val Ser Leu Leu Gly 
                565                 570                 575     


Pro Val Thr Thr Pro Glu His Gln Leu Leu Lys Thr Pro Ser Ser Ser 
            580                 585                 590         


Ser Leu Ser Gln Arg Val Arg Ser Thr Leu Thr Lys Asn Thr Pro Arg 
        595                 600                 605             


Phe Gly Ser Lys Ser Lys Ser Ala Thr Asn Leu Gly Arg Gln Gly Asn 
    610                 615                 620                 


Phe Phe Ala Ser Pro Met Leu Lys 
625                 630         


<210> 9053
<211> 377
<212> PRT
<213> Homo sapiens

<400> 9053
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Ile Met Ser Leu Ala Gly Lys Gly Asn Gln His Leu Val Thr Cys Phe 
            340                 345                 350         


Pro His Pro Val Ser Gly Gly Arg Ala Asn Cys Pro Ile Ser Thr Leu 
        355                 360                 365             


Ile Gln Ser Pro Trp Cys Gly Trp Gly 
    370                 375         


<210> 9054
<211> 377
<212> PRT
<213> Homo sapiens

<400> 9054
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Ile Met Ser Leu Ala Gly Lys Gly Asn Gln His Leu Val Thr Cys Phe 
            340                 345                 350         


Pro His Pro Val Ser Gly Gly Arg Ala Asn Cys Pro Ile Ser Thr Leu 
        355                 360                 365             


Ile Gln Ser Pro Trp Cys Gly Trp Gly 
    370                 375         


<210> 9055
<211> 257
<212> PRT
<213> Homo sapiens

<400> 9055
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Val Phe Tyr His Gly Cys Trp Leu Leu Ser Gly Cys 
                245                 250                 255     


Asp 
    


<210> 9056
<211> 481
<212> PRT
<213> Homo sapiens

<400> 9056
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Asn Leu Pro Asn His 
    290                 295                 300                 


Leu Val Ile Pro Thr Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 9057
<211> 198
<212> PRT
<213> Homo sapiens

<400> 9057
Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210> 9058
<211> 114
<212> PRT
<213> Homo sapiens

<400> 9058
Met Thr Thr Arg Gln Ala Thr Lys Asp Pro Leu Leu Arg Gly Val Ser 
1               5                   10                  15      


Pro Thr Pro Ser Lys Ile Pro Val Arg Ser Gln Lys Arg Thr Pro Phe 
            20                  25                  30          


Pro Thr Val Thr Ser Cys Ala Val Asp Gln Glu Asn Gln Asp Pro Arg 
        35                  40                  45              


Arg Trp Val Gln Lys Pro Pro Leu Asn Ile Gln Arg Pro Leu Val Asp 
    50                  55                  60                  


Ser Ala Gly Pro Arg Pro Lys Ala Arg His Gln Ala Glu Thr Ser Gln 
65                  70                  75                  80  


Arg Leu Val Gly Ile Ser Gln Pro Arg Asn Pro Leu Glu Glu Leu Arg 
                85                  90                  95      


Pro Ser Pro Arg Gly Gln Asn Val Gly Pro Gly Pro Pro Ala Gln Thr 
            100                 105                 110         


Glu Ala 
        


<210> 9059
<211> 481
<212> PRT
<213> Homo sapiens

<400> 9059
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Asn Leu Pro Asn His 
    290                 295                 300                 


Leu Val Ile Pro Thr Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 9060
<211> 131
<212> PRT
<213> Homo sapiens

<400> 9060
Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210> 9061
<211> 254
<212> PRT
<213> Homo sapiens

<400> 9061
Met Val Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu 
1               5                   10                  15      


Lys Glu Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala 
            20                  25                  30          


Leu Lys Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu 
        35                  40                  45              


Pro Leu Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn 
    50                  55                  60                  


Lys Ser Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val 
65                  70                  75                  80  


Ile Gln Pro Ile Val Lys Asp Cys Lys Glu Ala Asp Leu Ser Leu Tyr 
                85                  90                  95      


Asn Glu Phe Arg Leu Trp Lys Asp Glu Pro Thr Met Asp Arg Thr Cys 
            100                 105                 110         


Pro Phe Leu Asp Lys Ile Tyr Gln Glu Asp Ile Phe Pro Cys Leu Thr 
        115                 120                 125             


Phe Ser Lys Ser Glu Leu Ala Ser Ala Val Leu Glu Ala Val Glu Asn 
    130                 135                 140                 


Asn Thr Leu Ser Ile Glu Pro Val Gly Leu Gln Pro Ile Arg Phe Val 
145                 150                 155                 160 


Lys Ala Ser Ala Val Glu Cys Gly Gly Pro Lys Lys Cys Ala Leu Thr 
                165                 170                 175     


Gly Gln Ser Lys Ser Cys Lys His Arg Ile Lys Leu Gly Asp Ser Ser 
            180                 185                 190         


Asn Tyr Tyr Tyr Ile Ser Pro Phe Cys Arg Tyr Arg Ile Thr Ser Val 
        195                 200                 205             


Cys Asn Phe Phe Thr Tyr Ile Arg Tyr Ile Gln Gln Gly Leu Val Lys 
    210                 215                 220                 


Gln Gln Asp Val Asp Gln Met Phe Trp Glu Val Met Gln Leu Arg Lys 
225                 230                 235                 240 


Glu Met Ser Leu Ala Lys Leu Gly Tyr Phe Lys Glu Glu Leu 
                245                 250                 


<210> 9062
<211> 923
<212> PRT
<213> Homo sapiens

<400> 9062
Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His 
1               5                   10                  15      


Ala Leu Thr Val Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met 
            20                  25                  30          


Arg Gly Asp Gln Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile 
        35                  40                  45              


Ala Thr Gln Ala Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val 
    50                  55                  60                  


Arg Arg His Glu Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln 
65                  70                  75                  80  


Trp Lys Glu Ala Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu 
                85                  90                  95      


Gly Ala Ser Leu Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly 
            100                 105                 110         


Ser Ser Val Ala Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly 
        115                 120                 125             


Leu Leu Tyr Arg Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg 
    130                 135                 140                 


Ser Ala Ile Ser Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His 
145                 150                 155                 160 


Thr Gln Leu Arg Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu 
                165                 170                 175     


Leu Phe Ser Val Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val 
            180                 185                 190         


Val Val Gly Thr Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val 
        195                 200                 205             


Ala Val His Pro Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln 
    210                 215                 220                 


Leu Arg His Pro Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr 
225                 230                 235                 240 


Ala Val Gln Pro His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala 
                245                 250                 255     


His Ser Pro Ala Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro 
            260                 265                 270         


Leu Asn Val Ile Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp 
        275                 280                 285             


Trp Leu Gln Gly Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser 
    290                 295                 300                 


Val Leu Ser Glu Trp Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met 
305                 310                 315                 320 


Val Leu Pro Ile Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu 
                325                 330                 335     


Lys Asn Gln Trp Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala 
            340                 345                 350         


Lys Ala Val Glu Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln 
        355                 360                 365             


Lys Asn Trp Gln His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser 
    370                 375                 380                 


Arg Gln Leu Trp Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu 
385                 390                 395                 400 


Asp His Ala Gln Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu 
                405                 410                 415     


Ala Glu Ala Arg Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala 
            420                 425                 430         


Glu Leu Thr Leu Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser 
        435                 440                 445             


Ser Ala Leu Phe Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro 
    450                 455                 460                 


Asp Leu Ala Arg Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp 
465                 470                 475                 480 


Leu Leu Leu Phe Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu 
                485                 490                 495     


Thr Gly Gln Leu Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg 
            500                 505                 510         


Asp Arg Gln Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp 
        515                 520                 525             


Pro Arg Asp Ile Ile Ser Gly Val Glu Met Gln Val Leu Gln Glu Lys 
    530                 535                 540                 


Leu Arg Ser Gly Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala 
545                 550                 555                 560 


Ala Gln Lys Lys Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp 
                565                 570                 575     


Ala Leu Arg Phe Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu 
            580                 585                 590         


His Leu Ser Val Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys 
        595                 600                 605             


Ile Trp Asn Ala Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe 
    610                 615                 620                 


Val Pro Gln Pro Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala 
625                 630                 635                 640 


Trp Ile Leu Ser Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly 
                645                 650                 655     


Phe Leu Thr Arg Glu Leu Ser Leu Val Thr His Ala Leu His His Phe 
            660                 665                 670         


Trp Leu His Asn Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val 
        675                 680                 685             


Leu Trp His Ser Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser 
    690                 695                 700                 


Cys Ala Asp Leu Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu 
705                 710                 715                 720 


Ala Glu Glu Leu Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro 
                725                 730                 735     


Ala Pro Ser Ile Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu 
            740                 745                 750         


His Trp Arg Gln Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu 
        755                 760                 765             


Val Val Gln Val Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys 
    770                 775                 780                 


Ala Arg Pro Arg Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly 
785                 790                 795                 800 


Leu Phe Glu Ala Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly 
                805                 810                 815     


Ala Val Gly Leu Leu Pro Pro Gly Ala Ala Ala Pro Ser Gly Trp Ala 
            820                 825                 830         


Gln Ala Pro Leu Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly 
        835                 840                 845             


Leu Val Asp Pro Gln Ile Gln Leu Pro Leu Leu Ala Ala Arg Arg Tyr 
    850                 855                 860                 


Lys Leu Gln Lys Gln Leu Asp Ser Leu Thr Ala Arg Thr Pro Ser Glu 
865                 870                 875                 880 


Gly Glu Ala Gly Thr Gln Arg Gln Gln Lys Leu Ser Ser Leu Gln Leu 
                885                 890                 895     


Glu Leu Ser Lys Leu Asp Lys Ala Ala Ser His Leu Arg Gln Leu Met 
            900                 905                 910         


Asp Glu Pro Pro Ala Pro Gly Ser Pro Glu Leu 
        915                 920             


<210> 9063
<211> 1742
<212> PRT
<213> Homo sapiens

<400> 9063
Met Met Glu Gly Asn Gly Thr Glu Asn Ser Cys Ser Arg Thr Arg Gly 
1               5                   10                  15      


Trp Leu Gln Gln Asp Asn Asp Ala Lys Pro Trp Leu Trp Lys Phe Ser 
            20                  25                  30          


Asn Cys Phe Ser Arg Pro Glu Gln Thr Leu Pro His Ser Pro Gln Thr 
        35                  40                  45              


Lys Glu Tyr Met Glu Asn Lys Lys Val Ala Val Glu Leu Lys Asp Val 
    50                  55                  60                  


Pro Ser Pro Leu His Ala Gly Ser Lys Leu Phe Pro Ala Val Pro Leu 
65                  70                  75                  80  


Pro Asp Ile Arg Ser Leu Gln Gln Pro Lys Ile Gln Leu Ser Ser Val 
                85                  90                  95      


Pro Lys Val Ser Cys Cys Ala His Cys Pro Asn Glu Pro Ser Thr Ser 
            100                 105                 110         


Pro Met Arg Phe Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Ser Ser 
        115                 120                 125             


Leu Ile His Pro Gly Ala Leu Leu Asp Ser Gln Ser Thr Arg Thr Ile 
    130                 135                 140                 


Thr Cys Gln Val Gly Ser Gly Phe Ala Phe Gln Ser Ala Ser Ser Leu 
145                 150                 155                 160 


Gln Asn Ala Ser Ala Arg Asn Asn Leu Ala Gly Ile Ala Ser Asp Phe 
                165                 170                 175     


Pro Ser Met Cys Leu Glu Ser Asn Leu Ser Ser Cys Lys His Leu Pro 
            180                 185                 190         


Cys Cys Gly Lys Leu His Phe Gln Ser Cys His Gly Asn Val His Lys 
        195                 200                 205             


Leu His Gln Phe Pro Ser Leu Gln Gly Cys Thr Ser Ala Gly Tyr Phe 
    210                 215                 220                 


Pro Cys Ser Asp Phe Thr Ser Gly Ala Pro Gly His Leu Glu Glu His 
225                 230                 235                 240 


Ile Ser Gln Ser Glu Leu Thr Pro His Leu Cys Thr Asn Ser Leu His 
                245                 250                 255     


Leu Asn Val Val Pro Pro Val Cys Leu Lys Gly Ser Leu Tyr Cys Glu 
            260                 265                 270         


Asp Cys Leu Asn Lys Pro Ala Arg Asn Ser Ile Ile Asp Ala Ala Lys 
        275                 280                 285             


Val Trp Pro Asn Ile Pro Pro Pro Asn Thr Gln Pro Ala Pro Leu Ala 
    290                 295                 300                 


Val Pro Leu Cys Asn Gly Cys Gly Thr Lys Gly Thr Gly Lys Glu Thr 
305                 310                 315                 320 


Thr Leu Leu Leu Ala Thr Ser Leu Gly Lys Ala Ala Ser Lys Phe Gly 
                325                 330                 335     


Ser Pro Glu Val Ala Val Ala Gly Gln Val Leu Glu Asn Leu Pro Pro 
            340                 345                 350         


Ile Gly Val Phe Trp Asp Ile Glu Asn Cys Ser Val Pro Ser Gly Arg 
        355                 360                 365             


Ser Ala Thr Ala Val Val Gln Arg Ile Arg Glu Lys Phe Phe Lys Gly 
    370                 375                 380                 


His Arg Glu Ala Glu Phe Ile Cys Val Cys Asp Ile Ser Lys Glu Asn 
385                 390                 395                 400 


Lys Glu Val Ile Gln Glu Leu Asn Asn Cys Gln Val Thr Val Ala His 
                405                 410                 415     


Ile Asn Ala Thr Ala Lys Asn Ala Ala Asp Asp Lys Leu Arg Gln Ser 
            420                 425                 430         


Leu Arg Arg Phe Ala Asn Thr His Thr Ala Pro Ala Thr Val Val Leu 
        435                 440                 445             


Val Ser Thr Asp Val Asn Phe Ala Leu Glu Leu Ser Asp Leu Arg His 
    450                 455                 460                 


Arg His Gly Phe His Ile Ile Leu Val His Lys Asn Gln Ala Ser Glu 
465                 470                 475                 480 


Ala Leu Leu His His Ala Asn Glu Leu Ile Arg Phe Glu Glu Phe Ile 
                485                 490                 495     


Ser Asp Leu Pro Pro Arg Leu Pro Leu Lys Met Pro Cys His Thr Leu 
            500                 505                 510         


Leu Tyr Val Tyr Asn Leu Pro Ala Asn Lys Asp Gly Lys Ser Val Ser 
        515                 520                 525             


Asn Arg Leu Arg Arg Leu Ser Asp Asn Cys Gly Gly Lys Val Leu Ser 
    530                 535                 540                 


Ile Thr Gly Cys Ser Ala Ile Leu Arg Phe Ile Asn Gln Asp Ser Ala 
545                 550                 555                 560 


Glu Arg Ala Gln Lys Arg Met Glu Asn Glu Asp Val Phe Gly Asn Arg 
                565                 570                 575     


Ile Ile Val Ser Phe Thr Pro Lys Asn Arg Glu Leu Cys Glu Thr Lys 
            580                 585                 590         


Ser Ser Asn Ala Ile Ala Asp Lys Val Lys Ser Pro Lys Lys Leu Lys 
        595                 600                 605             


Asn Pro Lys Leu Cys Leu Ile Lys Asp Ala Ser Glu Gln Ser Ser Ser 
    610                 615                 620                 


Ala Lys Ala Thr Pro Gly Lys Gly Ser Gln Ala Asn Ser Gly Ser Ala 
625                 630                 635                 640 


Thr Lys Asn Thr Asn Val Lys Ser Leu Gln Glu Leu Cys Arg Met Glu 
                645                 650                 655     


Ser Lys Thr Gly His Arg Asn Ser Glu His Gln Gln Gly His Leu Arg 
            660                 665                 670         


Leu Val Val Pro Thr His Gly Asn Ser Ser Ala Ala Val Ser Thr Pro 
        675                 680                 685             


Lys Asn Ser Gly Val Ala Glu Pro Val Tyr Lys Thr Ser Gln Lys Lys 
    690                 695                 700                 


Glu Asn Leu Ser Ala Arg Ser Val Thr Ser Ser Pro Val Glu Lys Lys 
705                 710                 715                 720 


Asp Lys Glu Glu Thr Val Phe Gln Val Ser Tyr Pro Ser Ala Phe Ser 
                725                 730                 735     


Lys Leu Val Ala Ser Arg Gln Val Ser Pro Leu Leu Ala Ser Gln Ser 
            740                 745                 750         


Trp Ser Ser Ser Arg Ser Met Ser Pro Asn Leu Leu Asn Arg Ala Ser 
        755                 760                 765             


Pro Leu Ala Phe Asn Ile Ala Asn Ser Ser Ser Glu Ala Asp Cys Pro 
    770                 775                 780                 


Asp Pro Phe Ala Asn Gly Ala Asp Val Gln Val Ser Asn Ile Asp Tyr 
785                 790                 795                 800 


Arg Leu Ser Arg Lys Glu Leu Gln Gln Leu Leu Gln Glu Ala Phe Ala 
                805                 810                 815     


Arg His Gly Lys Val Lys Ser Val Glu Leu Ser Pro His Thr Asp Tyr 
            820                 825                 830         


Gln Leu Lys Ala Val Val Gln Met Glu Asn Leu Gln Asp Ala Ile Gly 
        835                 840                 845             


Ala Val Asn Ser Leu His Arg Tyr Lys Ile Gly Ser Lys Lys Ile Leu 
    850                 855                 860                 


Val Ser Leu Ala Thr Gly Ala Ala Ser Lys Ser Leu Ser Leu Leu Ser 
865                 870                 875                 880 


Ala Glu Thr Met Ser Val Leu Gln Asp Ala Pro Ala Cys Cys Leu Pro 
                885                 890                 895     


Leu Phe Lys Phe Thr Asp Ile Tyr Glu Lys Lys Phe Gly His Lys Leu 
            900                 905                 910         


Asn Val Ser Asp Leu Tyr Lys Leu Thr Asp Thr Val Ala Ile Arg Glu 
        915                 920                 925             


Gln Gly Asn Gly Arg Leu Val Cys Leu Leu Pro Ser Ser Gln Ala Arg 
    930                 935                 940                 


Gln Ser Pro Leu Gly Ser Ser Gln Ser His Asp Gly Ser Ser Thr Asn 
945                 950                 955                 960 


Cys Ser Pro Ile Ile Phe Glu Glu Leu Glu Tyr His Glu Pro Val Cys 
                965                 970                 975     


Arg Gln His Cys Ser Asn Lys Asp Phe Ser Glu His Glu Phe Asp Pro 
            980                 985                 990         


Asp Ser Tyr Lys Ile Pro Phe Val  Ile Leu Ser Leu Lys  Thr Phe Ala 
        995                 1000                 1005             


Pro Gln  Val His Ser Leu Leu  Gln Thr His Glu Gly  Thr Val Pro 
    1010                 1015                 1020             


Leu Leu  Ser Phe Pro Asp Cys  Tyr Ile Ala Glu Phe  Gly Asp Leu 
    1025                 1030                 1035             


Glu Val  Val Gln Glu Asn Gln  Gly Gly Val Pro Leu  Glu His Phe 
    1040                 1045                 1050             


Ile Thr  Cys Val Pro Gly Val  Asn Ile Ala Thr Ala  Gln Asn Gly 
    1055                 1060                 1065             


Ile Lys  Val Val Lys Trp Ile  His Asn Lys Pro Pro  Pro Pro Asn 
    1070                 1075                 1080             


Thr Asp  Pro Trp Leu Leu Arg  Ser Lys Ser Pro Val  Gly Asn Pro 
    1085                 1090                 1095             


Gln Leu  Ile Gln Phe Ser Arg  Glu Val Ile Asp Leu  Leu Lys Ser 
    1100                 1105                 1110             


Gln Pro  Ser Cys Val Ile Pro  Ile Ser His Phe Ile  Pro Ser Tyr 
    1115                 1120                 1125             


His His  His Phe Ala Lys Gln  Cys Arg Val Ser Asp  Tyr Gly Tyr 
    1130                 1135                 1140             


Ser Lys  Leu Ile Glu Leu Leu  Glu Ala Val Pro His  Val Leu Gln 
    1145                 1150                 1155             


Ile Leu  Gly Met Gly Ser Lys  Arg Leu Leu Thr Leu  Thr His Arg 
    1160                 1165                 1170             


Ala Gln  Val Lys Arg Phe Thr  Gln Asp Leu Leu Lys  Leu Leu Lys 
    1175                 1180                 1185             


Ser Gln  Ala Ser Lys Gln Val  Ile Val Arg Glu Phe  Ser Gln Ala 
    1190                 1195                 1200             


Tyr His  Trp Cys Phe Ser Lys  Asp Trp Asp Val Thr  Glu Tyr Gly 
    1205                 1210                 1215             


Val Cys  Glu Leu Ile Asp Ile  Val Ser Glu Ile Pro  Asp Thr Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ser Gln Gln Asp  Asn Glu Met Val Ile  Cys Ile Pro 
    1235                 1240                 1245             


Lys Arg  Glu Arg Thr Gln Asp  Glu Ile Glu Arg Thr  Lys Gln Phe 
    1250                 1255                 1260             


Ser Lys  Asp Val Val Asp Leu  Leu Arg His Gln Pro  His Phe Arg 
    1265                 1270                 1275             


Met Pro  Phe Asn Lys Phe Ile  Pro Ser Tyr His His  His Phe Gly 
    1280                 1285                 1290             


Arg Gln  Cys Lys Leu Ala Tyr  Tyr Gly Phe Thr Lys  Leu Leu Glu 
    1295                 1300                 1305             


Leu Phe  Glu Ala Ile Pro Asp  Thr Leu Gln Val Leu  Glu Cys Gly 
    1310                 1315                 1320             


Glu Glu  Lys Ile Leu Thr Leu  Thr Glu Val Glu Arg  Phe Lys Ala 
    1325                 1330                 1335             


Leu Ala  Ala Gln Phe Val Lys  Leu Leu Arg Ser Gln  Lys Asp Asn 
    1340                 1345                 1350             


Cys Leu  Met Met Thr Asp Leu  Leu Thr Glu Tyr Ala  Lys Thr Phe 
    1355                 1360                 1365             


Gly Tyr  Thr Phe Arg Leu Gln  Asp Tyr Asp Val Ser  Ser Ile Ser 
    1370                 1375                 1380             


Ala Leu  Thr Gln Lys Leu Cys  His Val Val Lys Val  Ala Asp Ile 
    1385                 1390                 1395             


Glu Ser  Gly Arg Gln Ile Gln  Leu Ile Asn Arg Lys  Ser Leu Arg 
    1400                 1405                 1410             


Ser Leu  Thr Ala Gln Leu Leu  Val Leu Leu Met Ser  Trp Glu Gly 
    1415                 1420                 1425             


Thr Thr  His Leu Ser Val Glu  Glu Leu Lys Arg His  Tyr Glu Ser 
    1430                 1435                 1440             


Thr His  Asn Thr Pro Leu Asn  Pro Cys Glu Tyr Gly  Phe Met Thr 
    1445                 1450                 1455             


Leu Thr  Glu Leu Leu Lys Ser  Leu Pro Tyr Leu Val  Glu Val Phe 
    1460                 1465                 1470             


Thr Asn  Asp Lys Met Glu Glu  Cys Val Lys Leu Thr  Ser Leu Tyr 
    1475                 1480                 1485             


Leu Phe  Ala Lys Asn Val Arg  Ser Leu Leu His Thr  Tyr His Tyr 
    1490                 1495                 1500             


Gln Gln  Ile Phe Leu His Glu  Phe Ser Met Ala Tyr  Thr Lys Tyr 
    1505                 1510                 1515             


Val Gly  Glu Thr Leu Gln Pro  Lys Thr Tyr Gly His  Ser Ser Val 
    1520                 1525                 1530             


Glu Glu  Leu Leu Gly Ala Ile  Pro Gln Val Val Trp  Ile Lys Gly 
    1535                 1540                 1545             


His Gly  His Lys Arg Ile Val  Val Leu Lys Asn Asp  Met Lys Ser 
    1550                 1555                 1560             


Arg Leu  Ser Ser Leu Ser Leu  Ser Pro Ala Asn His  Glu Asn Gln 
    1565                 1570                 1575             


Pro Ser  Glu Gly Glu Arg Ile  Leu Glu Val Pro Glu  Ser His Thr 
    1580                 1585                 1590             


Ala Ser  Glu Leu Lys Leu Gly  Ala Asp Gly Ser Gly  Pro Ser His 
    1595                 1600                 1605             


Thr Glu  Gln Glu Leu Leu Arg  Leu Thr Asp Asp Ser  Pro Val Asp 
    1610                 1615                 1620             


Leu Leu  Cys Ala Pro Val Pro  Ser Cys Leu Pro Ser  Pro Gln Leu 
    1625                 1630                 1635             


Arg Pro  Asp Pro Val Ile Leu  Gln Ser Ala Asp Leu  Ile Gln Phe 
    1640                 1645                 1650             


Glu Glu  Arg Pro Gln Glu Pro  Ser Glu Ile Met Ile  Leu Asn Gln 
    1655                 1660                 1665             


Glu Glu  Lys Met Glu Ile Pro  Ile Pro Gly Lys Ser  Lys Thr Leu 
    1670                 1675                 1680             


Thr Ser  Asp Ser Ser Ser Ser  Cys Ile Ser Ala Ala  Val Pro Val 
    1685                 1690                 1695             


Pro Pro  Cys Pro Ser Ser Glu  Thr Ser Glu Ser Leu  Leu Ser Lys 
    1700                 1705                 1710             


Asp Pro  Val Glu Ser Pro Ala  Lys Lys Gln Pro Lys  Asn Arg Val 
    1715                 1720                 1725             


Lys Leu  Ala Ala Asn Phe Ser  Leu Ala Pro Ile Thr  Lys Leu 
    1730                 1735                 1740         


<210> 9064
<211> 257
<212> PRT
<213> Homo sapiens

<400> 9064
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Val Phe Tyr His Gly Cys Trp Leu Leu Ser Gly Cys 
                245                 250                 255     


Asp 
    


<210> 9065
<211> 377
<212> PRT
<213> Homo sapiens

<400> 9065
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Ile Met Ser Leu Ala Gly Lys Gly Asn Gln His Leu Val Thr Cys Phe 
            340                 345                 350         


Pro His Pro Val Ser Gly Gly Arg Ala Asn Cys Pro Ile Ser Thr Leu 
        355                 360                 365             


Ile Gln Ser Pro Trp Cys Gly Trp Gly 
    370                 375         


<210> 9066
<211> 164
<212> PRT
<213> Homo sapiens

<400> 9066
Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr Ile 
1               5                   10                  15      


Leu Tyr Arg Leu Gln Val Gly Glu Val Val Thr Thr Ile Pro Thr Ile 
            20                  25                  30          


Gly Phe Asn Val Glu Thr Val Thr Tyr Lys Asn Leu Lys Phe Gln Val 
        35                  40                  45              


Trp Asp Leu Gly Gly Gln Thr Ser Ile Arg Pro Tyr Trp Arg Cys Tyr 
    50                  55                  60                  


Tyr Ser Asn Thr Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp Arg 
65                  70                  75                  80  


Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu Glu 
                85                  90                  95      


Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln Asp 
            100                 105                 110         


Met Glu Gln Ala Met Thr Ser Ser Glu Met Ala Asn Ser Leu Gly Leu 
        115                 120                 125             


Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Thr Ser Ala Thr 
    130                 135                 140                 


Lys Gly Thr Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Thr Leu 
145                 150                 155                 160 


Lys Ser Arg Gln 
                


<210> 9067
<211> 130
<212> PRT
<213> Homo sapiens

<400> 9067
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg 
    130 


<210> 9068
<211> 107
<212> PRT
<213> Homo sapiens

<400> 9068
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu 
            100                 105         


<210> 9069
<211> 294
<212> PRT
<213> Homo sapiens

<400> 9069
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
145                 150                 155                 160 


Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                165                 170                 175     


Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
            180                 185                 190         


Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
        195                 200                 205             


Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
    210                 215                 220                 


Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
225                 230                 235                 240 


Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                245                 250                 255     


Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
            260                 265                 270         


Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
        275                 280                 285             


Phe Val Ser Lys Thr Val 
    290                 


<210> 9070
<211> 167
<212> PRT
<213> Homo sapiens

<400> 9070
Met Glu Glu Thr Tyr Thr Asp Ser Leu Asp Pro Glu Lys Leu Leu Gln 
1               5                   10                  15      


Cys Pro Tyr Asp Lys Asn His Gln Ile Arg Ala Cys Arg Phe Pro Tyr 
            20                  25                  30          


His Leu Ile Lys Cys Arg Lys Asn His Pro Asp Val Ala Ser Lys Leu 
        35                  40                  45              


Ala Thr Cys Pro Phe Asn Ala Arg His Gln Val Pro Arg Ala Glu Ile 
    50                  55                  60                  


Ser His His Ile Ser Ser Cys Asp Asp Arg Ser Cys Ile Glu Gln Asp 
65                  70                  75                  80  


Val Val Asn Gln Thr Arg Ser Leu Arg Gln Glu Thr Leu Ala Glu Ser 
                85                  90                  95      


Thr Trp Gln Cys Pro Pro Cys Asp Glu Asp Trp Asp Lys Asp Leu Trp 
            100                 105                 110         


Glu Gln Thr Ser Thr Pro Phe Val Trp Gly Thr Thr His Tyr Ser Asp 
        115                 120                 125             


Asn Asn Ser Pro Ala Ser Asn Ile Val Thr Glu His Lys Asn Asn Leu 
    130                 135                 140                 


Ala Ser Gly Met Arg Val Pro Lys Ser Leu Pro Tyr Val Leu Pro Trp 
145                 150                 155                 160 


Lys Asn Asn Gly Asn Ala Gln 
                165         


<210> 9071
<211> 293
<212> PRT
<213> Homo sapiens

<400> 9071
Met Leu Arg Glu Pro Arg Lys Gln Gly Leu Ala Gly Arg Ala His Leu 
1               5                   10                  15      


Leu Ser Pro Gly Thr Thr Gly Ser Met Lys Thr Pro Val Glu Leu Ala 
            20                  25                  30          


Val Ser Gly Met Gln Thr Leu Gly Leu Gln His Arg Cys Arg Gly Gly 
        35                  40                  45              


Tyr Arg Val Lys Ala Arg Thr Ser Tyr Val Asp Glu Thr Leu Phe Gly 
    50                  55                  60                  


Ser Pro Ala Gly Thr Arg Pro Thr Pro Pro Asp Phe Asp Pro Pro Trp 
65                  70                  75                  80  


Val Glu Lys Ala Asn Arg Thr Arg Gly Val Gly Lys Glu Ala Ser Lys 
                85                  90                  95      


Ala Leu Gly Ala Lys Gly Ser Cys Glu Thr Thr Pro Ser Arg Gly Ser 
            100                 105                 110         


Thr Pro Thr Leu Thr Pro Arg Lys Lys Asn Lys Tyr Arg Pro Ile Ser 
        115                 120                 125             


His Thr Pro Ser Tyr Cys Asp Glu Ser Leu Phe Gly Ser Arg Ser Glu 
    130                 135                 140                 


Gly Ala Ser Phe Gly Ala Pro Arg Met Ala Lys Gly Asp Ala Ala Lys 
145                 150                 155                 160 


Leu Arg Ala Leu Leu Trp Thr Pro Pro Pro Thr Pro Arg Gly Ser His 
                165                 170                 175     


Ser Pro Arg Pro Arg Glu Ala Pro Leu Arg Ala Ile His Pro Ala Gly 
            180                 185                 190         


Pro Ser Lys Thr Glu Pro Gly Pro Ala Ala Asp Ser Gln Lys Leu Ser 
        195                 200                 205             


Met Gly Gly Leu His Ser Ser Arg Pro Leu Lys Arg Gly Leu Ser His 
    210                 215                 220                 


Ser Leu Thr His Leu Asn Val Pro Ser Thr Gly His Pro Ala Thr Ser 
225                 230                 235                 240 


Ala Pro His Thr Asn Gly Pro Gln Asp Leu Arg Pro Ser Thr Ser Gly 
                245                 250                 255     


Val Thr Phe Arg Ser Pro Leu Val Thr Ser Arg Ala Arg Ser Val Ser 
            260                 265                 270         


Ile Ser Val Pro Ser Thr Pro Arg Arg Gly Gly Ala Thr Gln Lys Pro 
        275                 280                 285             


Lys Pro Pro Trp Lys 
    290             


<210> 9072
<211> 1093
<212> PRT
<213> Homo sapiens

<400> 9072
Met Gly Gly Lys Ala Trp Pro Arg Arg Ala Val Gly Thr Ala Gly Gly 
1               5                   10                  15      


Pro Cys Ala Glu Gln Ile Ser Ala Pro Phe Gln Thr Leu Leu Met Pro 
            20                  25                  30          


His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu Arg His 
        35                  40                  45              


Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser Glu Pro 
    50                  55                  60                  


His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln Lys Arg 
65                  70                  75                  80  


Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly Glu Ser 
                85                  90                  95      


Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu Leu Val 
            100                 105                 110         


Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val Ser Gly 
        115                 120                 125             


Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala Trp Tyr 
    130                 135                 140                 


Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln Ala Arg 
145                 150                 155                 160 


Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro Pro Pro 
                165                 170                 175     


Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val Ala Ile 
            180                 185                 190         


Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln Val Leu 
        195                 200                 205             


Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala Val Val 
    210                 215                 220                 


Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu Leu Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala Lys Gly 
                245                 250                 255     


Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu Asp Trp 
            260                 265                 270         


Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala Val Thr 
        275                 280                 285             


Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg Asn His 
    290                 295                 300                 


Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser Asp Ile 
305                 310                 315                 320 


Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg Leu Pro 
                325                 330                 335     


Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val Ala Phe 
            340                 345                 350         


Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr Thr Arg 
        355                 360                 365             


Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro Asp Asp 
    370                 375                 380                 


Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro Leu Met 
385                 390                 395                 400 


Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro His Val 
                405                 410                 415     


Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala Asp Ala 
            420                 425                 430         


Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile Ala Glu 
        435                 440                 445             


Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly Leu His 
    450                 455                 460                 


Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu Arg Gly 
465                 470                 475                 480 


Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile Cys Ser 
                485                 490                 495     


Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp Phe Val 
            500                 505                 510         


Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu Ser Gly 
        515                 520                 525             


Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln His Trp 
    530                 535                 540                 


Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp Trp Gly 
545                 550                 555                 560 


His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln Gly Glu 
                565                 570                 575     


Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg Glu Val 
            580                 585                 590         


Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu Glu Arg 
        595                 600                 605             


Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe Pro Phe 
    610                 615                 620                 


Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg Phe Tyr 
625                 630                 635                 640 


Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe Trp Val 
                645                 650                 655     


Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu Pro Phe 
            660                 665                 670         


Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly Arg Lys 
        675                 680                 685             


Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile Ile Ser 
    690                 695                 700                 


Gly Val Glu Met Gln Leu Leu Gln Glu Lys Leu Arg Ser Gly Asn Leu 
705                 710                 715                 720 


Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys Asp Phe 
                725                 730                 735     


Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Thr Leu 
            740                 745                 750         


Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val Ser Glu 
        755                 760                 765             


Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala Leu Arg 
    770                 775                 780                 


Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro Ala Glu 
785                 790                 795                 800 


Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser Arg Leu 
                805                 810                 815     


Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg Glu Leu 
            820                 825                 830         


Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn Leu Cys 
        835                 840                 845             


Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser Pro Arg 
    850                 855                 860                 


Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu Gly Leu 
865                 870                 875                 880 


Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu Trp Gln 
                885                 890                 895     


Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile Ser Val 
            900                 905                 910         


Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln Pro Glu 
        915                 920                 925             


Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val Leu Arg 
    930                 935                 940                 


Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg Val Leu 
945                 950                 955                 960 


Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala Phe Leu 
                965                 970                 975     


Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu Leu Pro 
            980                 985                 990         


Pro Gly Thr Ala Ala Pro Ser Gly  Trp Ala Gln Ala Pro  Leu Ser Asp 
        995                 1000                 1005             


Thr Ala  Gln Val Tyr Met Glu  Leu Gln Gly Leu Val  Asp Pro Gln 
    1010                 1015                 1020             


Ile Gln  Leu Pro Leu Leu Ala  Ala Arg Arg Tyr Lys  Leu Gln Lys 
    1025                 1030                 1035             


Gln Leu  Asp Ser Leu Thr Ala  Arg Thr Pro Ser Glu  Gly Glu Ala 
    1040                 1045                 1050             


Gly Thr  Gln Arg Gln Gln Lys  Leu Ser Ser Leu Gln  Leu Glu Leu 
    1055                 1060                 1065             


Ser Lys  Leu Asp Lys Ala Ala  Ser His Leu Arg Gln  Leu Met Asp 
    1070                 1075                 1080             


Glu Pro  Pro Ala Pro Gly Ser  Pro Glu Leu 
    1085                 1090             


<210> 9073
<211> 91
<212> PRT
<213> Homo sapiens

<400> 9073
Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys 
                85                  90      


<210> 9074
<211> 129
<212> PRT
<213> Homo sapiens

<400> 9074
Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210> 9075
<211> 377
<212> PRT
<213> Homo sapiens

<400> 9075
Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Ile Met Ser Leu Ala Gly Lys Gly Asn Gln His Leu Val Thr Cys Phe 
            340                 345                 350         


Pro His Pro Val Ser Gly Gly Arg Ala Asn Cys Pro Ile Ser Thr Leu 
        355                 360                 365             


Ile Gln Ser Pro Trp Cys Gly Trp Gly 
    370                 375         


<210> 9076
<211> 676
<212> PRT
<213> Homo sapiens

<400> 9076
Met Ser Asp Gln Ile Lys Phe Ile Met Asp Ser Leu Asn Lys Glu Pro 
1               5                   10                  15      


Phe Arg Lys Asn Tyr Asn Leu Ile Thr Phe Asp Ser Leu Glu Pro Met 
            20                  25                  30          


Gln Leu Leu Gln Val Leu Ser Asp Val Leu Ala Glu Ile Asp Pro Lys 
        35                  40                  45              


Gln Leu Val Asp Ile Arg Glu Glu Met Pro Glu Gln Thr Ala Lys Arg 
    50                  55                  60                  


Met Leu Ser Leu Leu Gly Ile Leu Lys Tyr Lys Pro Ser Gly Asn Ala 
65                  70                  75                  80  


Thr Asp Met Ser Thr Phe Arg Gln Gly Leu Val Ile Gly Ser Lys Pro 
                85                  90                  95      


Val Ile Tyr Pro Val Leu His Trp Leu Leu Gln Arg Thr Asn Glu Leu 
            100                 105                 110         


Lys Lys Arg Ala Tyr Leu Ala Arg Phe Leu Ile Lys Leu Glu Val Pro 
        115                 120                 125             


Ser Glu Phe Leu Gln Asp Glu Thr Val Ala Asp Thr Asn Lys Gln Tyr 
    130                 135                 140                 


Glu Glu Leu Met Glu Ala Phe Lys Thr Leu His Lys Glu Tyr Glu Gln 
145                 150                 155                 160 


Leu Lys Ile Ser Gly Phe Ser Thr Ala Glu Ile Arg Lys Asp Ile Ser 
                165                 170                 175     


Ala Met Glu Glu Glu Lys Asp Gln Leu Ile Lys Arg Val Glu His Leu 
            180                 185                 190         


Lys Lys Arg Val Glu Thr Ala Gln Asn His Gln Trp Met Leu Lys Ile 
        195                 200                 205             


Ala Arg Gln Leu Arg Val Glu Lys Glu Arg Glu Glu Tyr Leu Ala Gln 
    210                 215                 220                 


Gln Lys Gln Glu Gln Lys Asn Gln Leu Phe His Ala Val Gln Arg Leu 
225                 230                 235                 240 


Gln Arg Val Gln Asn Gln Leu Lys Ser Met Arg Gln Ala Ala Ala Asp 
                245                 250                 255     


Ala Lys Pro Glu Ser Leu Met Lys Arg Leu Glu Glu Glu Ile Lys Phe 
            260                 265                 270         


Asn Leu Tyr Met Val Thr Glu Lys Phe Pro Lys Glu Leu Glu Asn Lys 
        275                 280                 285             


Lys Lys Glu Leu His Phe Leu Gln Lys Val Val Ser Glu Pro Ala Met 
    290                 295                 300                 


Gly His Ser Asp Leu Leu Glu Leu Glu Ser Lys Ile Asn Glu Ile Asn 
305                 310                 315                 320 


Thr Glu Ile Asn Gln Leu Ile Glu Lys Lys Met Met Arg Asn Glu Pro 
                325                 330                 335     


Ile Glu Gly Lys Leu Ser Leu Tyr Arg Gln Gln Ala Ser Ile Ile Ser 
            340                 345                 350         


Arg Lys Lys Glu Ala Lys Ala Glu Glu Leu Gln Glu Ala Lys Glu Lys 
        355                 360                 365             


Leu Ala Ser Leu Glu Arg Glu Ala Ser Val Lys Arg Asn Gln Thr Arg 
    370                 375                 380                 


Glu Phe Asp Gly Thr Glu Val Leu Lys Gly Asp Glu Phe Lys Arg Tyr 
385                 390                 395                 400 


Val Asn Lys Leu Arg Ser Lys Ser Thr Val Phe Lys Lys Lys His Gln 
                405                 410                 415     


Ile Ile Ala Glu Leu Lys Ala Glu Phe Gly Leu Leu Gln Arg Thr Glu 
            420                 425                 430         


Glu Leu Leu Lys Gln Arg His Glu Asn Ile Gln Gln Gln Leu Gln Thr 
        435                 440                 445             


Met Glu Glu Lys Lys Gly Ile Ser Gly Tyr Ser Tyr Thr Gln Glu Glu 
    450                 455                 460                 


Leu Glu Arg Val Ser Ala Leu Lys Ser Glu Val Asp Glu Met Lys Gly 
465                 470                 475                 480 


Arg Thr Leu Asp Asp Met Ser Glu Met Val Lys Lys Leu Tyr Ser Leu 
                485                 490                 495     


Val Ser Glu Lys Lys Ser Ala Leu Ala Ser Val Ile Lys Glu Leu Arg 
            500                 505                 510         


Gln Leu Arg Gln Lys Tyr Gln Glu Leu Thr Gln Glu Cys Asp Glu Lys 
        515                 520                 525             


Lys Ser Gln Tyr Asp Ser Cys Ala Ala Gly Leu Glu Ser Asn Arg Ser 
    530                 535                 540                 


Lys Leu Glu Gln Glu Val Arg Arg Leu Arg Glu Glu Cys Leu Gln Glu 
545                 550                 555                 560 


Glu Ser Arg Tyr His Tyr Thr Asn Cys Met Ile Lys Asn Leu Glu Val 
                565                 570                 575     


Gln Leu Arg Arg Ala Thr Asp Glu Met Lys Ala Tyr Ile Ser Ser Asp 
            580                 585                 590         


Gln Gln Glu Lys Arg Lys Ala Ile Arg Glu Gln Tyr Thr Lys Asn Thr 
        595                 600                 605             


Ala Glu Gln Glu Asn Leu Gly Lys Lys Leu Arg Glu Lys Gln Lys Val 
    610                 615                 620                 


Ile Arg Glu Ser His Gly Pro Asn Met Lys Gln Ala Lys Met Trp Arg 
625                 630                 635                 640 


Asp Leu Glu Gln Leu Met Glu Cys Lys Lys Gln Cys Phe Leu Lys Gln 
                645                 650                 655     


Gln Ser Gln Thr Ser Ile Gly Gln Val Ile Gln Glu Gly Gly Glu Asp 
            660                 665                 670         


Arg Leu Ile Leu 
        675     


<210> 9077
<211> 151
<212> PRT
<213> Homo sapiens

<400> 9077
Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
1               5                   10                  15      


Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
            20                  25                  30          


Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
        35                  40                  45              


His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
    50                  55                  60                  


Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
65                  70                  75                  80  


Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                85                  90                  95      


Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
            100                 105                 110         


Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
        115                 120                 125             


Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
    130                 135                 140                 


Thr Ile Asp Glu Ser Gly Ser 
145                 150     


<210> 9078
<211> 481
<212> PRT
<213> Homo sapiens

<400> 9078
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Asn Leu Pro Asn His 
    290                 295                 300                 


Leu Val Ile Pro Thr Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 9079
<211> 254
<212> PRT
<213> Homo sapiens

<400> 9079
Met Val Arg Glu Ala Asn Ile Lys Gln Ala Thr Ala Glu Lys Gln Leu 
1               5                   10                  15      


Lys Glu Ala Gln Gly Lys Ile Asp Val Leu Gln Ala Glu Val Ala Ala 
            20                  25                  30          


Leu Lys Thr Leu Val Leu Ser Ser Ser Pro Thr Ser Pro Thr Gln Glu 
        35                  40                  45              


Pro Leu Pro Gly Gly Lys Thr Pro Phe Lys Lys Gly His Thr Arg Asn 
    50                  55                  60                  


Lys Ser Thr Ser Ser Ala Met Ser Gly Ser His Gln Asp Leu Ser Val 
65                  70                  75                  80  


Ile Gln Pro Ile Val Lys Asp Cys Lys Glu Ala Asp Leu Ser Leu Tyr 
                85                  90                  95      


Asn Glu Phe Arg Leu Trp Lys Asp Glu Pro Thr Met Asp Arg Thr Cys 
            100                 105                 110         


Pro Phe Leu Asp Lys Ile Tyr Gln Glu Asp Ile Phe Pro Cys Leu Thr 
        115                 120                 125             


Phe Ser Lys Ser Glu Leu Ala Ser Ala Val Leu Glu Ala Val Glu Asn 
    130                 135                 140                 


Asn Thr Leu Ser Ile Glu Pro Val Gly Leu Gln Pro Ile Arg Phe Val 
145                 150                 155                 160 


Lys Ala Ser Ala Val Glu Cys Gly Gly Pro Lys Lys Cys Ala Leu Thr 
                165                 170                 175     


Gly Gln Ser Lys Ser Cys Lys His Arg Ile Lys Leu Gly Asp Ser Ser 
            180                 185                 190         


Asn Tyr Tyr Tyr Ile Ser Pro Phe Cys Arg Tyr Arg Ile Thr Ser Val 
        195                 200                 205             


Cys Asn Phe Phe Thr Tyr Ile Arg Tyr Ile Gln Gln Gly Leu Val Lys 
    210                 215                 220                 


Gln Gln Asp Val Asp Gln Met Phe Trp Glu Val Met Gln Leu Arg Lys 
225                 230                 235                 240 


Glu Met Ser Leu Ala Lys Leu Gly Tyr Phe Lys Glu Glu Leu 
                245                 250                 


<210> 9080
<211> 481
<212> PRT
<213> Homo sapiens

<400> 9080
Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Asn Leu Pro Asn His 
    290                 295                 300                 


Leu Val Ile Pro Thr Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Gly Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210> 9081
<211> 657
<212> PRT
<213> Homo sapiens

<400> 9081
Met Leu Gly Pro Ser Trp Asp Gly Asp Glu Ala Glu Ser Thr Gly Glu 
1               5                   10                  15      


Ile Ile Arg Leu Gly Asp Thr Ala His Thr Phe Ser Leu Arg Ser Asn 
            20                  25                  30          


Gly Ala Gln Cys Pro Asn Glu Met Leu Ser Lys Lys Ala Leu Ala Ser 
        35                  40                  45              


Pro Ser Ser Lys Ser His Glu Asp Met Leu Tyr Pro Pro Ser Val Leu 
    50                  55                  60                  


Ser Lys Ser Arg Thr Ser Phe Val Glu Asp Thr Glu Thr Leu Ser Val 
65                  70                  75                  80  


Ser Gly Ile Pro Asn Ala Arg Lys Leu Gly Glu Pro Ile Arg Ala Ala 
                85                  90                  95      


Ile Pro Leu His Pro Pro Tyr His Pro Ser Glu Pro Arg Ala Pro Cys 
            100                 105                 110         


Pro Ile Gly Lys Glu Tyr Leu His Ser Ser His Cys Ser Pro Ala Val 
        115                 120                 125             


Asn Ser Thr Gly Glu His Thr Glu Phe Ser Gly Asp Leu Asp Asp Gly 
    130                 135                 140                 


Leu Phe Leu Ile Ser Lys Leu Pro Lys Gly Ser Lys Trp Glu Val Tyr 
145                 150                 155                 160 


Pro Ala Gln Val Gln Gly Pro Arg Thr Arg Lys Pro Pro Lys Gly Lys 
                165                 170                 175     


Arg Asn Glu Asn Arg Ala Thr Ala Ser Ser Cys Asn Ser Pro Phe Pro 
            180                 185                 190         


Gln Arg Pro Arg Lys Arg Leu Thr Glu Gln Glu Leu His Asp Val Ser 
        195                 200                 205             


Glu Lys Leu Ser Gln Arg Leu Ser Glu Leu Asp Trp Met Leu Lys Ser 
    210                 215                 220                 


Ala Leu Gly Asp Arg Ile Lys Glu Lys Thr Asp His Lys Glu Glu Asn 
225                 230                 235                 240 


Thr Gly Asn Glu Glu Val Glu Asp Gly Thr Glu Glu Thr Leu Ser Gln 
                245                 250                 255     


His Ser Asp Gly Ile Val Glu Tyr Gly Pro Lys Lys Ser Arg Pro Gly 
            260                 265                 270         


Leu Ser Met Arg Arg Lys Pro Pro Tyr Arg Ser His Ser Leu Ser Pro 
        275                 280                 285             


Ser Pro Val Asn Lys His Lys Gln Phe His Leu Glu Arg Lys Arg Gln 
    290                 295                 300                 


Arg Lys Pro Arg Glu Thr Asp Val Arg Gln Phe Gln Ala Gln Ala Phe 
305                 310                 315                 320 


Thr Glu Ala Phe Glu Arg Glu Leu Arg Arg His Lys Val Gln Glu Asn 
                325                 330                 335     


Ile Gly Pro Leu Arg Ile His Glu Lys Glu Glu Glu Thr Glu Lys Ile 
            340                 345                 350         


Tyr Arg Gly Glu Ala Val Arg Lys Gly Thr Pro Glu Cys Ser Gln Pro 
        355                 360                 365             


Trp Lys Ile Tyr Ser Arg Lys Thr Thr Thr Gln Ser Leu Arg Gly Gly 
    370                 375                 380                 


Leu Pro Lys Pro Asn Lys Ala Val Pro Met Lys Val Ser Glu His Ser 
385                 390                 395                 400 


Leu Leu Pro Leu Met Leu Glu Gln Phe Pro Phe Leu Tyr Val Ser Gly 
                405                 410                 415     


Pro Thr Leu Ser Lys Met Trp Lys Gln Gln Ile Ala Gln Val Glu Gln 
            420                 425                 430         


Leu Lys Lys Glu Ala Cys Arg Glu Asn Arg Ser Lys Lys Lys Leu Gln 
        435                 440                 445             


Asp Glu Ile Glu Glu Ala Leu Arg Arg His Asp Leu Leu Thr Thr Leu 
    450                 455                 460                 


Val Lys Lys Glu Tyr Glu His Asn Lys Arg Leu Gln Asp Phe Lys Asp 
465                 470                 475                 480 


Cys Ile Arg Arg Gln Arg Leu Thr Gln Ser Lys Ile Lys Glu Asn Arg 
                485                 490                 495     


Gln Gln Ile Val Arg Ala Arg Lys Tyr Tyr Asp Asp Tyr Arg Val Gln 
            500                 505                 510         


Leu Cys Ala Lys Met Met Arg Met Arg Thr Arg Glu Glu Met Ile Phe 
        515                 520                 525             


Lys Lys Leu Phe Glu Glu Gly Leu Asn Ile Gln Lys Gln Arg Leu Arg 
    530                 535                 540                 


Asp Leu Arg Asn Tyr Ala Lys Glu Lys Arg Asp Glu Gln Arg Arg Arg 
545                 550                 555                 560 


His Gln Asp Glu Leu Asp Ser Met Glu Asn Tyr Tyr Lys Asp Gln Phe 
                565                 570                 575     


Ser Leu Leu Ala Glu Ala Ile Ser Gln Glu His Gln Glu Leu Lys Ala 
            580                 585                 590         


Arg Glu Lys Ser Gln Ala Gln Thr Leu His Lys Val Lys Arg Glu Leu 
        595                 600                 605             


Arg Ser Lys Met Glu Lys Glu Ile Gln Gln Leu Gln Asp Met Ile Thr 
    610                 615                 620                 


Gln Asn Asp Asp Asp Val Phe Phe Arg Glu Leu Glu Ala Glu Arg Phe 
625                 630                 635                 640 


Arg Ser Arg Leu Gln Leu Ala Ser Phe Gln Tyr Ser Lys Ser Pro Ser 
                645                 650                 655     


Leu 
    


<210> 9082
<211> 168
<212> PRT
<213> Homo sapiens

<400> 9082
Met Gln Thr Phe Leu Lys Gly Lys Arg Val Gly Tyr Trp Leu Ser Glu 
1               5                   10                  15      


Lys Lys Ile Lys Lys Leu Asn Phe Gln Ala Phe Ala Glu Leu Cys Arg 
            20                  25                  30          


Lys Arg Gly Met Glu Val Val Gln Leu Asn Leu Ser Arg Pro Ile Glu 
        35                  40                  45              


Glu Gln Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile 
    50                  55                  60                  


Leu Glu Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg 
65                  70                  75                  80  


Phe Gln Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro 
                85                  90                  95      


Leu Pro Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu 
            100                 105                 110         


Ile Arg Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro 
        115                 120                 125             


Pro Phe Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu 
    130                 135                 140                 


Leu Glu Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val 
145                 150                 155                 160 


Ala His Gly Thr Asn Ser His Glu 
                165             


<210> 9083
<211> 736
<212> PRT
<213> Homo sapiens

<400> 9083
Met Leu Ile Pro Ala Leu Gln Ile Ser Asp Ser Glu Ser Val Gly Leu 
1               5                   10                  15      


Glu Asp Gly Ile Glu Gln Ser Ala Tyr Leu Thr Glu Ser Lys Met Asn 
            20                  25                  30          


Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe Cys Arg 
        35                  40                  45              


Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr Lys Glu 
    50                  55                  60                  


Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser Ser Gly 
65                  70                  75                  80  


Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe Leu Ile 
                85                  90                  95      


Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys Cys Cys 
            100                 105                 110         


Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro Arg Cys 
        115                 120                 125             


Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys Ile Phe 
    130                 135                 140                 


Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg Pro Val 
145                 150                 155                 160 


Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys Thr Ile 
                165                 170                 175     


Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu Arg Ser 
            180                 185                 190         


Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln Val Gln 
        195                 200                 205             


Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys Asn Asn 
    210                 215                 220                 


Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His Ile Pro 
225                 230                 235                 240 


Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln Glu Leu 
                245                 250                 255     


Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys Lys Glu 
            260                 265                 270         


Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys Arg Cys 
        275                 280                 285             


Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser Leu Arg 
    290                 295                 300                 


Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile Ile Tyr 
305                 310                 315                 320 


Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro Asn Ser 
                325                 330                 335     


Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser Pro Lys 
            340                 345                 350         


Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu Arg Gln 
        355                 360                 365             


Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu Ile Glu Leu Gly 
    370                 375                 380                 


Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile Asn Lys Ala Asn 
385                 390                 395                 400 


Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg Asn Phe Asn Pro 
                405                 410                 415     


Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn Asp Asn Phe Gly 
            420                 425                 430         


Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser Leu Leu Met Gln 
        435                 440                 445             


His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu Ser Lys Asn Leu 
    450                 455                 460                 


Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr Tyr Glu Ala Gly 
465                 470                 475                 480 


Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro Gly Phe 
                485                 490                 495     


Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu Asn Thr 
            500                 505                 510         


Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln Ile Ile 
        515                 520                 525             


Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser Ile Ile 
    530                 535                 540                 


Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg Leu Ile 
545                 550                 555                 560 


Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu Gly Tyr 
                565                 570                 575     


His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys Gln Gly 
            580                 585                 590         


Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro Glu Ala 
        595                 600                 605             


Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala Lys Ile 
    610                 615                 620                 


Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys Ala Leu 
625                 630                 635                 640 


Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys Ser Thr 
                645                 650                 655     


Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser Ser Ile 
            660                 665                 670         


Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu His Val 
        675                 680                 685             


Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile Pro Ile 
    690                 695                 700                 


Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr Ile Arg 
705                 710                 715                 720 


Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile Gly His 
                725                 730                 735     


<210> 9084
<211> 376
<212> PRT
<213> Homo sapiens

<400> 9084
Met Ala Asn Ser Ala Asn Thr Asn Thr Val Pro Lys Leu Tyr Arg Ser 
1               5                   10                  15      


Val Ile Glu Asp Val Ile Asn Asp Val Arg Asp Ile Phe Leu Asp Asp 
            20                  25                  30          


Gly Val Asp Glu Gln Val Leu Met Glu Leu Lys Thr Leu Trp Glu Asn 
        35                  40                  45              


Lys Leu Met Gln Ser Arg Ala Val Asp Gly Phe His Ser Glu Glu Gln 
    50                  55                  60                  


Gln Leu Leu Leu Gln Val Gln Gln Gln His Gln Pro Gln Gln Gln Gln 
65                  70                  75                  80  


His His His His His His His Gln Gln Ala Gln Pro Gln Gln Thr Val 
                85                  90                  95      


Pro Gln Gln Ala Gln Thr Gln Gln Val Leu Ile Pro Ala Ser Gln Gln 
            100                 105                 110         


Ala Thr Ala Pro Gln Val Ile Val Pro Asp Ser Lys Leu Ile Gln His 
        115                 120                 125             


Met Asn Ala Ser Asn Met Ser Ala Ala Ala Thr Ala Ala Thr Leu Ala 
    130                 135                 140                 


Leu Pro Ala Gly Val Thr Pro Val Gln Gln Ile Leu Thr Asn Ser Gly 
145                 150                 155                 160 


Gln Leu Leu Gln Val Val Arg Ala Ala Asn Gly Ala Gln Tyr Ile Phe 
                165                 170                 175     


Gln Pro Gln Gln Ser Val Val Leu Gln Gln Gln Val Ile Pro Gln Met 
            180                 185                 190         


Gln Pro Gly Gly Val Gln Ala Pro Val Ile Gln Gln Val Leu Ala Pro 
        195                 200                 205             


Leu Pro Gly Gly Ile Ser Pro Gln Thr Gly Val Ile Ile Gln Pro Gln 
    210                 215                 220                 


Gln Ile Leu Phe Thr Gly Asn Lys Thr Gln Val Ile Pro Thr Thr Val 
225                 230                 235                 240 


Ala Ala Pro Thr Pro Ala Gln Ala Gln Ile Thr Ala Thr Gly Gln Gln 
                245                 250                 255     


Gln Pro Gln Ala Gln Pro Ala Gln Thr Gln Ala Pro Leu Val Leu Gln 
            260                 265                 270         


Val Asp Gly Thr Gly Asp Thr Ser Ser Glu Glu Asp Glu Asp Glu Glu 
        275                 280                 285             


Glu Asp Tyr Asp Asp Asp Glu Glu Glu Asp Lys Glu Lys Asp Gly Ala 
    290                 295                 300                 


Glu Asp Gly Gln Val Glu Glu Glu Pro Leu Asn Ser Glu Asp Asp Val 
305                 310                 315                 320 


Ser Asp Glu Glu Gly Gln Glu Leu Phe Asp Thr Glu Asn Val Val Val 
                325                 330                 335     


Cys Gln Tyr Asp Lys Ile His Arg Ser Lys Asn Lys Trp Lys Phe His 
            340                 345                 350         


Leu Lys Asp Gly Ile Met Asn Leu Asn Gly Arg Asp Tyr Ile Phe Ser 
        355                 360                 365             


Lys Ala Ile Gly Asp Ala Glu Trp 
    370                 375     


<210> 9085
<211> 78
<212> PRT
<213> Homo sapiens

<400> 9085
Met Glu Thr Asp Cys Asn Pro Met Glu Leu Ser Ser Met Ser Gly Phe 
1               5                   10                  15      


Glu Glu Gly Ser Glu Leu Asn Gly Phe Glu Gly Thr Asp Met Lys Asp 
            20                  25                  30          


Met Arg Leu Glu Ala Glu Ala Val Val Asn Asp Val Leu Phe Ala Val 
        35                  40                  45              


Asn Asn Met Phe Val Ser Lys Ser Leu Arg Cys Ala Asp Asp Val Ala 
    50                  55                  60                  


Tyr Ile Asn Val Glu Thr Lys Glu Arg Asn Arg Tyr Cys Leu 
65                  70                  75              


<210> 9086
<211> 248
<212> PRT
<213> Homo sapiens

<400> 9086
Met Ala Phe Ser Gly Arg Ala Arg Pro Cys Ile Ile Pro Glu Asn Glu 
1               5                   10                  15      


Glu Ile Pro Arg Ala Ala Leu Asn Thr Val His Glu Ala Asn Gly Thr 
            20                  25                  30          


Glu Asp Glu Arg Ala Val Ser Lys Leu Gln Arg Arg His Ser Asp Val 
        35                  40                  45              


Lys Val Tyr Lys Glu Phe Cys Asp Phe Tyr Ala Lys Phe Asn Met Ala 
    50                  55                  60                  


Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly Phe Ala 
65                  70                  75                  80  


Pro Ala Glu Thr Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu Gln 
                85                  90                  95      


Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly Leu Phe 
            100                 105                 110         


Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu 
        115                 120                 125             


Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly Arg Val 
    130                 135                 140                 


Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg Cys Asp 
145                 150                 155                 160 


Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn Ala Gly 
                165                 170                 175     


Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg Gly Leu 
            180                 185                 190         


Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu Gln Pro 
        195                 200                 205             


Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn Cys Ala 
    210                 215                 220                 


Asn Cys Gly Gln Glu Gly Ser Asp Cys Arg Cys Thr Gly Ala Glu Arg 
225                 230                 235                 240 


Gly Ala Ile Leu Pro Ala Met Pro 
                245             


<210> 9087
<211> 789
<212> PRT
<213> Homo sapiens

<400> 9087
Met Ser Ala Gln Thr Ser Pro Ala Glu Lys Gly Leu Asn Pro Gly Leu 
1               5                   10                  15      


Met Cys Gln Glu Ser Tyr Ala Cys Ser Gly Thr Asp Glu Ala Ile Phe 
            20                  25                  30          


Glu Cys Asp Glu Cys Cys Ser Leu Gln Cys Leu Arg Cys Glu Glu Glu 
        35                  40                  45              


Leu His Arg Gln Glu Arg Leu Arg Asn His Glu Arg Ile Arg Leu Lys 
    50                  55                  60                  


Pro Gly His Val Pro Tyr Cys Asp Leu Cys Lys Gly Leu Ser Gly His 
65                  70                  75                  80  


Leu Pro Gly Val Arg Gln Arg Ala Ile Val Arg Cys Gln Thr Cys Lys 
                85                  90                  95      


Ile Asn Leu Cys Leu Glu Cys Gln Lys Arg Thr His Ser Gly Gly Asn 
            100                 105                 110         


Lys Arg Arg His Pro Val Thr Val Tyr Asn Val Ser Asn Leu Gln Glu 
        115                 120                 125             


Ser Leu Glu Ala Glu Glu Met Asp Glu Glu Thr Lys Arg Lys Lys Met 
    130                 135                 140                 


Thr Glu Lys Val Val Ser Phe Leu Leu Val Asp Glu Asn Glu Glu Ile 
145                 150                 155                 160 


Gln Val Thr Asn Glu Glu Asp Phe Ile Arg Lys Leu Asp Cys Lys Pro 
                165                 170                 175     


Asp Gln His Leu Lys Val Val Ser Ile Phe Gly Asn Thr Gly Asp Gly 
            180                 185                 190         


Lys Ser His Thr Leu Asn His Thr Phe Phe Tyr Gly Arg Glu Val Phe 
        195                 200                 205             


Lys Thr Ser Pro Thr Gln Glu Ser Cys Thr Val Gly Val Trp Ala Ala 
    210                 215                 220                 


Tyr Asp Pro Val His Lys Val Ala Val Ile Asp Thr Glu Gly Leu Leu 
225                 230                 235                 240 


Gly Ala Thr Val Asn Leu Ser Gln Arg Thr Arg Leu Leu Leu Lys Val 
                245                 250                 255     


Leu Ala Ile Ser Asp Leu Val Ile Tyr Arg Thr His Ala Asp Arg Leu 
            260                 265                 270         


His Asn Asp Leu Phe Lys Phe Leu Gly Asp Ala Ser Glu Ala Tyr Leu 
        275                 280                 285             


Lys His Phe Thr Lys Glu Leu Lys Ala Thr Thr Ala Arg Cys Gly Leu 
    290                 295                 300                 


Asp Val Pro Leu Ser Thr Leu Gly Pro Ala Val Ile Ile Phe His Glu 
305                 310                 315                 320 


Thr Val His Thr Gln Leu Leu Gly Ser Asp His Pro Ser Glu Val Pro 
                325                 330                 335     


Glu Lys Leu Ile Gln Asp Arg Phe Arg Lys Leu Gly Arg Phe Pro Glu 
            340                 345                 350         


Ala Phe Ser Ser Ile His Tyr Lys Gly Thr Arg Thr Tyr Asn Pro Pro 
        355                 360                 365             


Thr Asp Phe Ser Gly Leu Arg Arg Ala Leu Glu Gln Leu Leu Glu Asn 
    370                 375                 380                 


Asn Thr Thr Arg Ser Pro Arg His Pro Gly Val Ile Phe Lys Ala Leu 
385                 390                 395                 400 


Lys Ala Leu Ser Asp Arg Phe Ser Gly Glu Ile Pro Asp Asp Gln Met 
                405                 410                 415     


Ala His Ser Ser Phe Phe Pro Asp Glu Tyr Phe Thr Cys Ser Ser Leu 
            420                 425                 430         


Cys Leu Ser Cys Gly Val Gly Cys Lys Lys Ser Met Asn His Gly Lys 
        435                 440                 445             


Glu Gly Val Pro His Glu Ala Lys Ser Arg Cys Arg Tyr Ser His Gln 
    450                 455                 460                 


Tyr Asp Asn Arg Val Tyr Thr Cys Lys Ala Cys Tyr Glu Arg Gly Glu 
465                 470                 475                 480 


Glu Val Ser Val Val Pro Lys Thr Ser Ala Ser Thr Asp Ser Pro Trp 
                485                 490                 495     


Met Gly Leu Ala Lys Tyr Ala Trp Ser Gly Tyr Val Ile Glu Cys Pro 
            500                 505                 510         


Asn Cys Gly Val Val Tyr Arg Ser Arg Gln Tyr Trp Phe Gly Asn Gln 
        515                 520                 525             


Asp Pro Val Asp Thr Val Val Arg Thr Glu Ile Val His Val Trp Pro 
    530                 535                 540                 


Gly Thr Asp Gly Phe Leu Lys Asp Asn Asn Asn Ala Ala Gln Arg Leu 
545                 550                 555                 560 


Leu Asp Gly Met Asn Phe Met Ala Gln Ser Val Ser Glu Leu Ser Leu 
                565                 570                 575     


Gly Pro Thr Lys Ala Val Thr Ser Trp Leu Thr Asp Gln Ile Ala Pro 
            580                 585                 590         


Ala Tyr Trp Arg Pro Asn Ser Gln Ile Leu Ser Cys Asn Lys Cys Ala 
        595                 600                 605             


Thr Ser Phe Lys Asp Asn Asp Thr Lys His His Cys Arg Ala Cys Gly 
    610                 615                 620                 


Glu Gly Phe Cys Asp Ser Cys Ser Ser Lys Thr Arg Pro Val Pro Glu 
625                 630                 635                 640 


Arg Gly Trp Gly Pro Ala Pro Val Arg Val Cys Asp Asn Cys Tyr Glu 
                645                 650                 655     


Ala Arg Asn Val Gln Leu Ala Val Thr Glu Ala Gln Val Asp Asp Glu 
            660                 665                 670         


Gly Gly Thr Leu Ile Ala Arg Lys Val Gly Glu Ala Val Gln Asn Thr 
        675                 680                 685             


Leu Gly Ala Val Val Thr Ala Ile Asp Ile Pro Leu Gly Leu Val Lys 
    690                 695                 700                 


Asp Ala Ala Arg Pro Ala Tyr Trp Val Pro Asp His Glu Ile Leu His 
705                 710                 715                 720 


Cys His Asn Cys Arg Lys Glu Phe Ser Ile Lys Leu Ser Lys His His 
                725                 730                 735     


Cys Arg Ala Cys Gly Gln Gly Phe Cys Asp Glu Cys Ser His Asp Arg 
            740                 745                 750         


Arg Ala Val Pro Ser Arg Gly Trp Asp His Pro Val Arg Val Cys Phe 
        755                 760                 765             


Asn Cys Asn Lys Lys Pro Ala Trp Thr Ser Leu Ser Val Met Thr Gly 
    770                 775                 780                 


Lys Gly Pro Leu Cys 
785                 


<210> 9088
<211> 756
<212> PRT
<213> Homo sapiens

<400> 9088
Leu Ala Gly Asn Glu Thr Glu Trp Val Thr Ile Ala Asn Asn Leu Leu 
1               5                   10                  15      


Phe Lys Cys His Ile His Leu Arg Ile His Glu Leu Gln Asp Cys Asp 
            20                  25                  30          


Ala Asn Val Phe Ile Ala Leu Tyr Gln Ser Ile Leu Gly Glu Lys Val 
        35                  40                  45              


Pro Asp Leu Ile Val Ile Pro Arg Ser Gln Glu Asp Asp Ala His Asn 
    50                  55                  60                  


Val Gln Ala Val Ile Asp Ser Leu Ala Leu Asp Tyr Leu Gln Val Ser 
65                  70                  75                  80  


Leu Ser His Ile Thr Ala Leu Tyr Ser Val Ser Arg Arg Lys Tyr Ser 
                85                  90                  95      


Glu Arg Arg Met Leu Gly Pro Ser Trp Asp Gly Asp Glu Ala Glu Ser 
            100                 105                 110         


Thr Gly Glu Ile Ile Arg Leu Gly Asp Thr Ala His Thr Phe Ser Leu 
        115                 120                 125             


Arg Ser Asn Gly Ala Gln Cys Pro Asn Glu Met Leu Ser Lys Lys Ala 
    130                 135                 140                 


Leu Ala Ser Pro Ser Ser Lys Ser His Glu Asp Met Leu Tyr Pro Pro 
145                 150                 155                 160 


Ser Val Leu Ser Lys Ser Arg Thr Ser Phe Val Glu Asp Thr Glu Thr 
                165                 170                 175     


Leu Ser Val Ser Gly Ile Pro Asn Ala Arg Lys Leu Gly Glu Pro Ile 
            180                 185                 190         


Arg Ala Ala Ile Pro Leu His Pro Pro Tyr His Pro Ser Glu Pro Arg 
        195                 200                 205             


Ala Pro Cys Pro Ile Gly Lys Glu Tyr Leu His Ser Ser His Cys Ser 
    210                 215                 220                 


Pro Ala Val Asn Ser Thr Gly Glu His Thr Glu Phe Ser Gly Asp Leu 
225                 230                 235                 240 


Asp Asp Gly Leu Phe Leu Ile Ser Lys Leu Pro Lys Gly Ser Lys Trp 
                245                 250                 255     


Glu Val Tyr Pro Ala Gln Val Gln Gly Pro Arg Thr Arg Lys Pro Pro 
            260                 265                 270         


Lys Gly Lys Arg Asn Glu Asn Arg Ala Thr Ala Ser Ser Cys Asn Ser 
        275                 280                 285             


Pro Phe Pro Gln Arg Pro Arg Lys Arg Leu Thr Glu Gln Glu Leu His 
    290                 295                 300                 


Asp Val Ser Glu Lys Leu Ser Gln Arg Leu Ser Glu Leu Asp Trp Met 
305                 310                 315                 320 


Leu Lys Ser Ala Leu Gly Asp Arg Ile Lys Glu Lys Thr Asp His Lys 
                325                 330                 335     


Glu Glu Asn Thr Gly Asn Glu Glu Val Glu Asp Gly Thr Glu Glu Thr 
            340                 345                 350         


Leu Ser Gln His Ser Asp Gly Ile Val Glu Tyr Gly Pro Lys Lys Ser 
        355                 360                 365             


Arg Pro Gly Leu Ser Met Arg Arg Lys Pro Pro Tyr Arg Ser His Ser 
    370                 375                 380                 


Leu Ser Pro Ser Pro Val Asn Lys His Lys Gln Phe His Leu Glu Arg 
385                 390                 395                 400 


Lys Arg Gln Arg Lys Pro Arg Glu Thr Asp Val Arg Gln Phe Gln Ala 
                405                 410                 415     


Gln Ala Phe Thr Glu Ala Phe Glu Arg Glu Leu Arg Arg His Lys Val 
            420                 425                 430         


Gln Glu Asn Ile Gly Pro Leu Arg Ile His Glu Lys Glu Glu Glu Thr 
        435                 440                 445             


Val Gly Lys Asn Ile Gln Arg Arg Ser Phe Val Lys Glu Leu Gln Asn 
    450                 455                 460                 


Val Val Ser Pro Gly Arg Phe Thr Leu Glu Lys Pro Gln Arg Arg Val 
465                 470                 475                 480 


Arg Gly Gly Leu Pro Lys Pro Asn Lys Ala Val Pro Met Lys Val Ser 
                485                 490                 495     


Glu His Ser Leu Leu Pro Leu Met Leu Glu Gln Phe Pro Phe Leu Tyr 
            500                 505                 510         


Val Ser Gly Pro Thr Leu Ser Lys Met Trp Lys Gln Gln Ile Ala Gln 
        515                 520                 525             


Val Glu Gln Leu Lys Lys Glu Ala Cys Arg Glu Asn Arg Ser Lys Lys 
    530                 535                 540                 


Lys Leu Gln Asp Glu Ile Glu Glu Ala Leu Arg Arg His Asp Leu Leu 
545                 550                 555                 560 


Thr Thr Leu Val Lys Lys Glu Tyr Glu His Asn Lys Arg Leu Gln Asp 
                565                 570                 575     


Phe Lys Asp Cys Ile Arg Arg Gln Arg Leu Thr Gln Ser Lys Ile Lys 
            580                 585                 590         


Glu Asn Arg Gln Gln Ile Val Arg Ala Arg Lys Tyr Tyr Asp Asp Tyr 
        595                 600                 605             


Arg Val Gln Leu Cys Ala Lys Met Met Arg Met Arg Thr Arg Glu Glu 
    610                 615                 620                 


Met Ile Phe Lys Lys Leu Phe Glu Glu Gly Leu Asn Ile Gln Lys Gln 
625                 630                 635                 640 


Arg Leu Arg Asp Leu Arg Asn Tyr Ala Lys Glu Lys Arg Asp Glu Gln 
                645                 650                 655     


Arg Arg Arg His Gln Asp Glu Leu Asp Ser Met Glu Asn Tyr Tyr Lys 
            660                 665                 670         


Asp Gln Phe Ser Leu Leu Ala Glu Ala Ile Ser Gln Glu His Gln Glu 
        675                 680                 685             


Leu Lys Ala Arg Glu Lys Ser Gln Ala Gln Thr Leu His Lys Val Lys 
    690                 695                 700                 


Arg Glu Leu Arg Ser Lys Met Glu Lys Glu Ile Gln Gln Leu Gln Asp 
705                 710                 715                 720 


Met Ile Thr Gln Asn Asp Asp Asp Val Phe Phe Arg Glu Leu Glu Ala 
                725                 730                 735     


Glu Arg Phe Arg Ser Arg Leu Gln Leu Ala Ser Phe Gln Tyr Ser Lys 
            740                 745                 750         


Ser Pro Ser Leu 
        755     


<210> 9089
<211> 139
<212> PRT
<213> Homo sapiens

<400> 9089
Met Glu Thr Asp Cys Asn Pro Met Glu Leu Ser Ser Met Ser Gly Phe 
1               5                   10                  15      


Glu Glu Gly Ser Glu Leu Asn Gly Phe Glu Gly Thr Asp Met Lys Asp 
            20                  25                  30          


Met Arg Leu Glu Ala Glu Ala Val Val Asn Asp Val Leu Phe Ala Val 
        35                  40                  45              


Asn Asn Met Phe Val Ser Lys Ser Leu Arg Cys Ala Asp Asp Val Ala 
    50                  55                  60                  


Tyr Ile Asn Val Glu Thr Lys Glu Arg Asn Arg Tyr Cys Leu Glu Leu 
65                  70                  75                  80  


Thr Glu Ala Gly Leu Lys Val Val Gly Tyr Ala Phe Asp Gln Val Asp 
                85                  90                  95      


Asp His Leu Gln Thr Pro Tyr His Glu Thr Val Tyr Ser Leu Leu Asp 
            100                 105                 110         


Thr Leu Ser Pro Ala Tyr Arg Glu Ala Phe Gly Asn Ala Leu Leu Gln 
        115                 120                 125             


Arg Leu Glu Ala Leu Lys Arg Asp Gly Gln Ser 
    130                 135                 


<210> 9090
<211> 99
<212> PRT
<213> Homo sapiens

<400> 9090
Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val 
            20                  25                  30          


Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys 
                85                  90                  95      


Ile Cys Gln 
            


<210> 9091
<211> 820
<212> PRT
<213> Homo sapiens

<400> 9091
Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val 
            20                  25                  30          


Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys 
                85                  90                  95      


Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Asp Ile Thr Gln Asp 
            100                 105                 110         


Leu Val Asp Glu Ser Glu Glu Glu Arg Phe Asp Asp Met Ser Ser Pro 
        115                 120                 125             


Gly Leu Glu Leu Pro Ser Cys Glu Leu Ser Arg Leu Glu Glu Ile Ala 
    130                 135                 140                 


Glu Leu Val Ala Ser Ser Leu Pro Ser Pro Leu Arg Arg Glu Lys Leu 
145                 150                 155                 160 


Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu Glu Leu 
                165                 170                 175     


Phe His Val Cys Glu Asp Leu Glu Asn Ile Glu Gly Leu His His Leu 
            180                 185                 190         


Tyr Glu Ile Ile Lys Gly Ile Phe Leu Leu Asn Arg Thr Ala Leu Phe 
        195                 200                 205             


Glu Val Met Phe Ser Glu Glu Cys Ile Met Asp Val Ile Gly Cys Leu 
    210                 215                 220                 


Glu Tyr Asp Pro Ala Leu Ser Gln Pro Arg Lys His Arg Glu Phe Leu 
225                 230                 235                 240 


Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Ser Asp Pro Glu 
                245                 250                 255     


Leu Lys Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile Gln Asp 
            260                 265                 270         


Met Val Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Met Leu Ser Thr 
        275                 280                 285             


Leu His Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Gly Met Leu 
    290                 295                 300                 


Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr Asp 
305                 310                 315                 320 


Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Val Asn Phe Leu Lys 
                325                 330                 335     


Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg Asp Ala 
            340                 345                 350         


Phe Phe Lys Thr Leu Ser Asn Met Gly Ile Leu Pro Ala Leu Glu Val 
        355                 360                 365             


Ile Leu Gly Met Asp Asp Thr Gln Val Arg Ser Ala Ala Thr Asp Ile 
    370                 375                 380                 


Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met Val Arg Glu Phe Val 
385                 390                 395                 400 


Met Gln Glu Ala Gln Gln Asn Asp Asp Asp Ile Leu Leu Ile Asn Leu 
                405                 410                 415     


Ile Ile Glu His Met Ile Cys Asp Thr Asp Pro Glu Leu Gly Gly Ala 
            420                 425                 430         


Val Gln Leu Met Gly Leu Leu Arg Thr Leu Val Asp Pro Glu Asn Met 
        435                 440                 445             


Leu Ala Thr Ala Asn Lys Thr Glu Lys Thr Glu Phe Leu Gly Phe Phe 
    450                 455                 460                 


Tyr Lys His Cys Met His Val Leu Thr Ala Pro Leu Leu Ala Asn Thr 
465                 470                 475                 480 


Thr Glu Asp Lys Pro Ser Lys Asp Asp Phe Gln Thr Ala Gln Leu Leu 
                485                 490                 495     


Ala Leu Val Leu Glu Leu Leu Thr Phe Cys Val Glu His His Thr Tyr 
            500                 505                 510         


His Ile Lys Asn Tyr Ile Ile Asn Lys Asp Ile Leu Arg Arg Val Leu 
        515                 520                 525             


Val Leu Met Ala Ser Lys His Ala Phe Leu Ala Leu Cys Ala Leu Arg 
    530                 535                 540                 


Phe Lys Arg Lys Ile Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr 
545                 550                 555                 560 


Ile Met Lys Ser Phe Leu Phe Glu Pro Val Val Lys Ala Phe Leu Asn 
                565                 570                 575     


Asn Gly Ser Arg Tyr Asn Leu Met Asn Ser Ala Ile Ile Glu Met Phe 
            580                 585                 590         


Glu Phe Ile Arg Val Glu Asp Ile Lys Ser Leu Thr Ala His Val Ile 
        595                 600                 605             


Glu Asn Tyr Trp Lys Ala Leu Glu Asp Val Asp Tyr Val Gln Thr Phe 
    610                 615                 620                 


Lys Gly Leu Lys Leu Arg Phe Glu Gln Gln Arg Glu Arg Gln Asp Asn 
625                 630                 635                 640 


Pro Lys Leu Asp Ser Met Arg Ser Ile Leu Arg Asn His Arg Tyr Arg 
                645                 650                 655     


Arg Asp Ala Arg Thr Leu Glu Asp Glu Glu Glu Met Trp Phe Asn Thr 
            660                 665                 670         


Asp Glu Asp Asp Met Glu Asp Gly Glu Ala Val Val Ser Pro Ser Asp 
        675                 680                 685             


Lys Thr Lys Asn Asp Asp Asp Ile Met Asp Pro Ile Ser Lys Phe Met 
    690                 695                 700                 


Glu Arg Lys Lys Leu Lys Glu Ser Glu Glu Lys Glu Val Leu Leu Lys 
705                 710                 715                 720 


Thr Asn Leu Ser Gly Arg Gln Ser Pro Ser Phe Lys Leu Ser Leu Ser 
                725                 730                 735     


Ser Gly Thr Lys Thr Asn Leu Thr Ser Gln Ser Ser Thr Thr Asn Leu 
            740                 745                 750         


Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro 
        755                 760                 765             


Gly Ser Val Pro Lys Asn Thr Ser Gln Thr Ala Ala Ile Thr Thr Lys 
    770                 775                 780                 


Gly Gly Leu Val Gly Leu Val Asp Tyr Pro Asp Asp Asp Glu Asp Asp 
785                 790                 795                 800 


Asp Glu Asp Glu Asp Lys Glu Asp Thr Leu Pro Leu Ser Lys Lys Ala 
                805                 810                 815     


Lys Phe Asp Ser 
            820 


<210> 9092
<211> 131
<212> PRT
<213> Homo sapiens

<400> 9092
Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln 
    130     


<210> 9093
<211> 1977
<212> PRT
<213> Homo sapiens

<400> 9093
Met Ala Ala Arg Ser Ala Pro Ser Cys His Leu Arg Leu Glu Trp Val 
1               5                   10                  15      


Tyr Gly Tyr Arg Gly His Gln Cys Arg Asn Asn Leu Tyr Tyr Thr Ala 
            20                  25                  30          


Ala Lys Glu Ile Val Tyr Phe Val Ala Gly Val Gly Val Val Tyr Ser 
        35                  40                  45              


Pro Arg Glu His Arg Gln Lys Phe Tyr Arg Gly His Ser Asp Asp Ile 
    50                  55                  60                  


Ile Ser Leu Ala Leu His Pro Glu Arg Val Leu Val Ala Thr Gly Gln 
65                  70                  75                  80  


Val Gly Lys Glu Pro Tyr Ile Cys Ile Trp Asp Ser Tyr Thr Val Gln 
                85                  90                  95      


Thr Ile Ser Val Leu Lys Asp Val His Thr His Gly Ile Ala Cys Leu 
            100                 105                 110         


Ala Phe Asp Leu Asp Gly Gln Arg Leu Val Ser Val Gly Leu Asp Ser 
        115                 120                 125             


Lys Asn Ala Val Cys Val Trp Asp Trp Lys Arg Gly Lys Met Leu Ser 
    130                 135                 140                 


Met Ala Pro Gly His Thr Asp Arg Ile Phe Asp Ile Ser Trp Asp Leu 
145                 150                 155                 160 


Tyr Gln Pro Asn Lys Leu Val Ser Cys Gly Val Lys His Ile Lys Phe 
                165                 170                 175     


Trp Ser Leu Cys Gly Asn Ala Leu Thr Pro Lys Arg Gly Val Phe Gly 
            180                 185                 190         


Lys Thr Gly Asp Leu Gln Thr Ile Leu Cys Leu Ala Cys Ala Arg Asp 
        195                 200                 205             


Glu Leu Thr Tyr Ser Gly Ala Leu Asn Gly Asp Ile Tyr Val Trp Lys 
    210                 215                 220                 


Gly Ile Asn Leu Ile Arg Thr Ile Gln Gly Ala His Ala Ala Gly Ile 
225                 230                 235                 240 


Phe Ser Met Asn Ala Cys Glu Glu Gly Phe Ala Thr Gly Gly Arg Asp 
                245                 250                 255     


Gly Cys Ile Arg Leu Trp Asp Leu Thr Phe Lys Pro Ile Thr Val Ile 
            260                 265                 270         


Asp Leu Arg Glu Thr Asp Gln Gly Tyr Lys Gly Leu Ser Val Arg Ser 
        275                 280                 285             


Val Cys Trp Arg Gly Asp His Ile Leu Val Gly Thr Gln Asp Ser Glu 
    290                 295                 300                 


Ile Phe Glu Ile Val Val Gln Glu Arg Asn Lys Pro Phe Leu Ile Met 
305                 310                 315                 320 


Gln Gly His Cys Glu Gly Glu Leu Trp Ala Leu Ala Val His Pro Thr 
                325                 330                 335     


Lys Pro Leu Ala Val Thr Gly Ser Asp Asp Arg Ser Val Arg Ile Trp 
            340                 345                 350         


Ser Leu Val Asp His Ala Leu Ile Ala Arg Cys Asn Met Glu Glu Pro 
        355                 360                 365             


Ile Arg Cys Ala Ala Val Asn Ala Asp Gly Ile His Leu Ala Leu Gly 
    370                 375                 380                 


Met Lys Asp Gly Ser Phe Thr Val Leu Arg Val Arg Asp Met Thr Glu 
385                 390                 395                 400 


Val Val His Ile Lys Asp Arg Lys Glu Ala Ile His Glu Leu Lys Tyr 
                405                 410                 415     


Ser Pro Asp Gly Thr Tyr Leu Ala Val Gly Cys Asn Asp Ser Ser Val 
            420                 425                 430         


Asp Ile Tyr Gly Val Ala Gln Arg Tyr Lys Lys Val Gly Glu Cys Leu 
        435                 440                 445             


Gly Ser Leu Ser Phe Ile Thr His Leu Asp Trp Ser Ser Asp Ser Arg 
    450                 455                 460                 


Tyr Leu Gln Thr Asn Asp Gly Asn Gly Lys Arg Leu Phe Tyr Arg Met 
465                 470                 475                 480 


Pro Gly Gly Lys Glu Val Thr Ser Thr Glu Glu Ile Lys Gly Val His 
                485                 490                 495     


Trp Ala Ser Trp Thr Cys Val Ser Gly Leu Glu Val Asn Gly Ile Trp 
            500                 505                 510         


Pro Lys Tyr Ser Asp Ile Asn Asp Ile Asn Ser Val Asp Gly Asn Tyr 
        515                 520                 525             


Ile Gly Gln Val Leu Val Thr Ala Asp Asp Tyr Gly Ile Ile Lys Leu 
    530                 535                 540                 


Phe Arg Tyr Pro Cys Leu Arg Lys Gly Ala Lys Phe Arg Lys Tyr Ile 
545                 550                 555                 560 


Gly His Ser Ala His Val Thr Asn Val Arg Trp Ser His Asp Tyr Gln 
                565                 570                 575     


Trp Val Ile Ser Ile Gly Gly Ala Asp His Ser Val Phe Gln Trp Lys 
            580                 585                 590         


Phe Ile Pro Glu Arg Lys Leu Lys Asp Ala Val His Ile Ala Pro Gln 
        595                 600                 605             


Glu Ser Leu Ala Asp Ser His Ser Asp Glu Ser Asp Ser Asp Leu Ser 
    610                 615                 620                 


Asp Val Pro Glu Leu Asp Ser Glu Ile Glu Gln Glu Thr Gln Leu Thr 
625                 630                 635                 640 


Tyr Arg Arg Gln Val Tyr Lys Glu Asp Leu Pro Gln Leu Lys Glu Gln 
                645                 650                 655     


Cys Lys Glu Lys Gln Lys Ser Ala Thr Ser Lys Arg Arg Glu Arg Ala 
            660                 665                 670         


Pro Gly Asn Ser Ile Arg Leu His Phe Val His Gly Tyr Arg Gly Tyr 
        675                 680                 685             


Asp Cys Arg Ser Asn Leu Phe Tyr Thr Gln Ile Gly Glu Ile Val Tyr 
    690                 695                 700                 


His Val Ala Ala Val Gly Val Ile Tyr Asn Arg Gln Gln Asn Thr Gln 
705                 710                 715                 720 


Arg Phe Tyr Leu Gly His Asp Asp Asp Ile Leu Cys Leu Thr Ile His 
                725                 730                 735     


Pro Leu Lys Asp Tyr Val Ala Thr Gly Gln Val Gly Arg Asp Pro Ser 
            740                 745                 750         


Ile His Ile Trp Asp Thr Glu Thr Ile Lys Pro Leu Ser Ile Leu Lys 
        755                 760                 765             


Gly His His Gln Tyr Gly Val Ser Ala Val Asp Phe Ser Ala Asp Gly 
    770                 775                 780                 


Lys Arg Leu Ala Ser Val Gly Ile Asp Asp Ser His Thr Val Val Leu 
785                 790                 795                 800 


Trp Asp Trp Lys Lys Gly Glu Lys Leu Ser Ile Ala Arg Gly Ser Lys 
                805                 810                 815     


Asp Lys Ile Phe Val Val Lys Met Asn Pro Tyr Val Pro Asp Lys Leu 
            820                 825                 830         


Ile Thr Ala Gly Ile Lys His Met Lys Phe Trp Arg Lys Ala Gly Gly 
        835                 840                 845             


Gly Leu Ile Gly Arg Lys Gly Tyr Ile Gly Thr Leu Gly Lys Asn Asp 
    850                 855                 860                 


Thr Met Met Cys Ala Val Tyr Gly Trp Thr Glu Glu Met Ala Phe Ser 
865                 870                 875                 880 


Gly Thr Ser Thr Gly Asp Val Cys Ile Trp Arg Asp Ile Phe Leu Val 
                885                 890                 895     


Lys Thr Val Lys Ala His Asp Gly Pro Val Phe Ser Met His Ala Leu 
            900                 905                 910         


Glu Lys Gly Phe Val Thr Gly Gly Lys Asp Gly Ile Val Ala Leu Trp 
        915                 920                 925             


Asp Asp Ser Phe Glu Arg Cys Leu Lys Thr Tyr Ala Ile Lys Arg Ala 
    930                 935                 940                 


Ala Leu Ala Pro Gly Ser Lys Gly Leu Leu Leu Glu Asp Asn Pro Ser 
945                 950                 955                 960 


Ile Arg Ala Ile Ser Leu Gly His Gly His Ile Leu Val Gly Thr Lys 
                965                 970                 975     


Asn Gly Glu Ile Leu Glu Val Asp Lys Ser Gly Pro Ile Thr Leu Leu 
            980                 985                 990         


Val Gln Gly His Met Glu Gly Glu  Val Trp Gly Leu Ala  Thr His Pro 
        995                 1000                 1005             


Tyr Leu  Pro Ile Cys Ala Thr  Val Ser Asp Asp Lys  Thr Leu Arg 
    1010                 1015                 1020             


Ile Trp  Asp Leu Ser Pro Ser  His Cys Met Leu Ala  Val Arg Lys 
    1025                 1030                 1035             


Leu Lys  Lys Gly Gly Arg Cys  Cys Cys Phe Ser Pro  Asp Gly Lys 
    1040                 1045                 1050             


Ala Leu  Ala Val Gly Leu Asn  Asp Gly Ser Phe Leu  Met Ala Asn 
    1055                 1060                 1065             


Ala Asp  Thr Leu Glu Asp Leu  Val Ser Phe His His  Arg Lys Asp 
    1070                 1075                 1080             


Met Ile  Ser Asp Ile Arg Phe  Ser Pro Gly Ser Gly  Lys Tyr Leu 
    1085                 1090                 1095             


Ala Val  Ala Ser His Asp Ser  Phe Ile Asp Ile Tyr  Asn Val Met 
    1100                 1105                 1110             


Ser Ser  Lys Arg Val Gly Ile  Cys Lys Gly Ala Thr  Ser Tyr Ile 
    1115                 1120                 1125             


Thr His  Ile Asp Trp Asp Ile  Arg Gly Lys Leu Leu  Gln Val Asn 
    1130                 1135                 1140             


Thr Gly  Ala Lys Glu Gln Leu  Phe Phe Glu Ala Pro  Arg Gly Lys 
    1145                 1150                 1155             


Lys Gln  Thr Ile Pro Ser Val  Glu Val Glu Lys Ile  Ala Trp Ala 
    1160                 1165                 1170             


Ser Trp  Thr Ser Val Leu Gly  Leu Cys Cys Glu Gly  Ile Trp Pro 
    1175                 1180                 1185             


Val Ile  Gly Glu Val Thr Asp  Val Thr Ala Ser Cys  Leu Thr Ser 
    1190                 1195                 1200             


Asp Lys  Met Val Leu Ala Thr  Gly Asp Asp Leu Gly  Phe Val Lys 
    1205                 1210                 1215             


Leu Phe  Arg Tyr Pro Thr Lys  Gly Lys Phe Gly Lys  Phe Lys Arg 
    1220                 1225                 1230             


Tyr Val  Ala His Ser Thr His  Val Thr Asn Val Arg  Trp Thr Tyr 
    1235                 1240                 1245             


Asp Asp  Ser Met Leu Val Thr  Leu Gly Gly Thr Asp  Met Ser Leu 
    1250                 1255                 1260             


Met Val  Trp Thr Asn Glu Met  Glu Gly Tyr Arg Glu  Lys Arg Pro 
    1265                 1270                 1275             


Cys Asp  Ser Glu Glu Ser Asp  Ile Asp Ser Glu Glu  Asp Gly Gly 
    1280                 1285                 1290             


Tyr Asp  Ser Asp Val Thr Arg  Glu Asn Glu Ile Ser  Tyr Thr Ile 
    1295                 1300                 1305             


Arg Ala  Leu Ser Thr Asn Ile  Arg Pro Met Leu Gly  Ile Lys Pro 
    1310                 1315                 1320             


His Leu  Gln Gln Lys Glu Pro  Ser Ile Asp Glu Arg  Gln Gly Val 
    1325                 1330                 1335             


Val Arg  Gly Ser Arg Pro Pro  Val Ser Arg Ala Pro  Pro Gln Pro 
    1340                 1345                 1350             


Glu Lys  Leu Gln Thr Asn Asn  Val Gly Lys Lys Lys  Arg Pro Ile 
    1355                 1360                 1365             


Glu Asp  Leu Val Leu Glu Leu  Ile Phe Gly Tyr Arg  Gly Arg Asp 
    1370                 1375                 1380             


Cys Arg  Asn Asn Val His Tyr  Leu Asn Asp Gly Asp  Asp Ile Ile 
    1385                 1390                 1395             


Tyr His  Thr Ala Ser Val Gly  Ile Leu His Asn Val  Ala Thr Gly 
    1400                 1405                 1410             


Ser Gln  Ser Phe Tyr Gln Glu  His Asn Asp Asp Ile  Leu Cys Leu 
    1415                 1420                 1425             


Thr Val  Asn Gln His Pro Lys  Phe Ile Asn Ile Val  Ala Thr Gly 
    1430                 1435                 1440             


Gln Val  Gly Asp Ser Ala Asp  Met Ser Ala Thr Ala  Pro Ser Ile 
    1445                 1450                 1455             


His Ile  Trp Asp Ala Met Asn  Lys Gln Thr Leu Ser  Ile Leu Arg 
    1460                 1465                 1470             


Cys Tyr  His Ser Lys Gly Val  Cys Ser Val Ser Phe  Ser Ala Thr 
    1475                 1480                 1485             


Gly Lys  Leu Leu Leu Ser Val  Gly Leu Asp Pro Glu  His Thr Ile 
    1490                 1495                 1500             


Thr Ile  Trp Arg Trp Gln Glu  Gly Ala Lys Ile Ala  Ser Arg Ala 
    1505                 1510                 1515             


Gly His  Asn Gln Arg Ile Phe  Val Ala Glu Phe Arg  Pro Asp Ser 
    1520                 1525                 1530             


Asp Thr  Gln Phe Val Ser Val  Gly Val Lys His Val  Lys Phe Trp 
    1535                 1540                 1545             


Thr Leu  Ala Gly Arg Ala Leu  Leu Ser Lys Lys Gly  Leu Leu Ser 
    1550                 1555                 1560             


Thr Leu  Glu Asp Ala Arg Met  Gln Thr Met Leu Ala  Ile Ala Phe 
    1565                 1570                 1575             


Gly Ala  Asn Asn Leu Thr Phe  Thr Gly Thr Ile Ser  Gly Asp Val 
    1580                 1585                 1590             


Cys Val  Trp Lys Asp His Ile  Leu Cys Arg Ile Val  Ala Arg Ala 
    1595                 1600                 1605             


His Asn  Gly Pro Val Phe Ala  Met Tyr Thr Thr Leu  Arg Asp Gly 
    1610                 1615                 1620             


Leu Ile  Val Thr Gly Gly Lys  Glu Arg Pro Ser Lys  Glu Gly Gly 
    1625                 1630                 1635             


Ala Val  Lys Leu Trp Asp Gln  Glu Leu Arg Arg Cys  Arg Ala Phe 
    1640                 1645                 1650             


Arg Leu  Glu Thr Gly Gln Ala  Thr Asp Cys Val Arg  Ser Val Cys 
    1655                 1660                 1665             


Arg Gly  Lys Gly Lys Ile Leu  Val Gly Thr Arg Asn  Ala Glu Ile 
    1670                 1675                 1680             


Ile Glu  Val Gly Glu Lys Asn  Ala Ala Cys Asn Ile  Leu Val Asn 
    1685                 1690                 1695             


Gly His  Val Asp Gly Pro Ile  Trp Gly Leu Ala Thr  His Pro Ser 
    1700                 1705                 1710             


Arg Asp  Phe Phe Leu Ser Ala  Ala Glu Asp Gly Thr  Val Arg Leu 
    1715                 1720                 1725             


Trp Asp  Ile Ala Asp Lys Lys  Met Leu Asn Lys Val  Asn Leu Gly 
    1730                 1735                 1740             


His Ala  Ala Arg Thr Val Cys  Tyr Ser Pro Glu Gly  Asp Met Val 
    1745                 1750                 1755             


Ala Ile  Gly Met Lys Asn Gly  Glu Phe Ile Ile Leu  Leu Val Ser 
    1760                 1765                 1770             


Ser Leu  Lys Ile Trp Gly Lys  Lys Arg Asp Arg Arg  Cys Ala Ile 
    1775                 1780                 1785             


His Asp  Ile Arg Phe Ser Pro  Asp Ser Arg Tyr Leu  Ala Val Gly 
    1790                 1795                 1800             


Ser Ser  Glu Asn Ser Val Asp  Phe Tyr Asp Leu Thr  Leu Gly Pro 
    1805                 1810                 1815             


Thr Leu  Asn Arg Ile Ser Tyr  Cys Lys Asp Ile Pro  Ser Phe Val 
    1820                 1825                 1830             


Ile Gln  Met Asp Phe Ser Ala  Asp Ser Ser Tyr Leu  Gln Val Ser 
    1835                 1840                 1845             


Ser Gly  Cys Tyr Lys Arg His  Val Tyr Glu Val Pro  Ser Gly Lys 
    1850                 1855                 1860             


His Leu  Met Asp His Ala Ala  Ile Asp Arg Ile Thr  Trp Ala Thr 
    1865                 1870                 1875             


Trp Thr  Ser Ile Leu Gly Asp  Glu Val Leu Gly Ile  Trp Ser Arg 
    1880                 1885                 1890             


His Ala  Glu Lys Ala Asp Val  Asn Cys Ala Cys Val  Ser His Ser 
    1895                 1900                 1905             


Gly Ile  Ser Leu Val Thr Gly  Asp Asp Phe Gly Met  Val Lys Leu 
    1910                 1915                 1920             


Phe Asp  Phe Pro Cys Pro Glu  Lys Phe Ala Lys His  Lys Arg Phe 
    1925                 1930                 1935             


Leu Gly  His Ser Pro His Val  Thr Asn Ile Arg Phe  Thr Ser Gly 
    1940                 1945                 1950             


Asp Arg  His Val Val Ser Ala  Gly Gly Asp Asp Cys  Ser Leu Phe 
    1955                 1960                 1965             


Val Trp  Lys Cys Val His Thr  Pro His 
    1970                 1975         


<210> 9094
<211> 833
<212> PRT
<213> Homo sapiens

<400> 9094
Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val 
            20                  25                  30          


Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys 
                85                  90                  95      


Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Asp Ile Thr Gln Asp 
            100                 105                 110         


Leu Val Asp Glu Ser Glu Glu Glu Arg Phe Asp Asp Met Ser Ser Pro 
        115                 120                 125             


Gly Leu Glu Leu Pro Ser Cys Glu Leu Ser Arg Leu Glu Glu Ile Ala 
    130                 135                 140                 


Glu Leu Val Ala Ser Ser Leu Pro Ser Pro Leu Arg Arg Glu Lys Leu 
145                 150                 155                 160 


Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu Glu Leu 
                165                 170                 175     


Phe His Val Cys Glu Asp Leu Glu Asn Ile Glu Gly Leu His His Leu 
            180                 185                 190         


Tyr Glu Ile Ile Lys Gly Ile Phe Leu Leu Asn Arg Thr Ala Leu Phe 
        195                 200                 205             


Glu Val Met Phe Ser Glu Glu Cys Ile Met Asp Val Ile Gly Cys Leu 
    210                 215                 220                 


Glu Tyr Asp Pro Ala Leu Ser Gln Pro Arg Lys His Arg Glu Phe Leu 
225                 230                 235                 240 


Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Ser Asp Pro Glu 
                245                 250                 255     


Leu Lys Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile Gln Asp 
            260                 265                 270         


Met Val Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Met Leu Ser Thr 
        275                 280                 285             


Leu His Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Gly Met Leu 
    290                 295                 300                 


Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr Asp 
305                 310                 315                 320 


Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Val Asn Phe Leu Lys 
                325                 330                 335     


Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg Asp Ala 
            340                 345                 350         


Phe Phe Lys Thr Leu Ser Asn Met Gly Ile Leu Pro Ala Leu Glu Val 
        355                 360                 365             


Ile Leu Gly Met Asp Asp Thr Gln Val Arg Ser Ala Ala Thr Asp Ile 
    370                 375                 380                 


Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met Val Arg Glu Phe Val 
385                 390                 395                 400 


Met Gln Glu Ala Gln Gln Asn Asp Asp Val Ser Lys Lys Leu Thr Glu 
                405                 410                 415     


Gln Lys Ile Thr Ser Lys Asp Ile Leu Leu Ile Asn Leu Ile Ile Glu 
            420                 425                 430         


His Met Ile Cys Asp Thr Asp Pro Glu Leu Gly Gly Ala Val Gln Leu 
        435                 440                 445             


Met Gly Leu Leu Arg Thr Leu Val Asp Pro Glu Asn Met Leu Ala Thr 
    450                 455                 460                 


Ala Asn Lys Thr Glu Lys Thr Glu Phe Leu Gly Phe Phe Tyr Lys His 
465                 470                 475                 480 


Cys Met His Val Leu Thr Ala Pro Leu Leu Ala Asn Thr Thr Glu Asp 
                485                 490                 495     


Lys Pro Ser Lys Asp Asp Phe Gln Thr Ala Gln Leu Leu Ala Leu Val 
            500                 505                 510         


Leu Glu Leu Leu Thr Phe Cys Val Glu His His Thr Tyr His Ile Lys 
        515                 520                 525             


Asn Tyr Ile Ile Asn Lys Asp Ile Leu Arg Arg Val Leu Val Leu Met 
    530                 535                 540                 


Ala Ser Lys His Ala Phe Leu Ala Leu Cys Ala Leu Arg Phe Lys Arg 
545                 550                 555                 560 


Lys Ile Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr Ile Met Lys 
                565                 570                 575     


Ser Phe Leu Phe Glu Pro Val Val Lys Ala Phe Leu Asn Asn Gly Ser 
            580                 585                 590         


Arg Tyr Asn Leu Met Asn Ser Ala Ile Ile Glu Met Phe Glu Phe Ile 
        595                 600                 605             


Arg Val Glu Asp Ile Lys Ser Leu Thr Ala His Val Ile Glu Asn Tyr 
    610                 615                 620                 


Trp Lys Ala Leu Glu Asp Val Asp Tyr Val Gln Thr Phe Lys Gly Leu 
625                 630                 635                 640 


Lys Leu Arg Phe Glu Gln Gln Arg Glu Arg Gln Asp Asn Pro Lys Leu 
                645                 650                 655     


Asp Ser Met Arg Ser Ile Leu Arg Asn His Arg Tyr Arg Arg Asp Ala 
            660                 665                 670         


Arg Thr Leu Glu Asp Glu Glu Glu Met Trp Phe Asn Thr Asp Glu Asp 
        675                 680                 685             


Asp Met Glu Asp Gly Glu Ala Val Val Ser Pro Ser Asp Lys Thr Lys 
    690                 695                 700                 


Asn Asp Asp Asp Ile Met Asp Pro Ile Ser Lys Phe Met Glu Arg Lys 
705                 710                 715                 720 


Lys Leu Lys Glu Ser Glu Glu Lys Glu Val Leu Leu Lys Thr Asn Leu 
                725                 730                 735     


Ser Gly Arg Gln Ser Pro Ser Phe Lys Leu Ser Leu Ser Ser Gly Thr 
            740                 745                 750         


Lys Thr Asn Leu Thr Ser Gln Ser Ser Thr Thr Asn Leu Pro Gly Ser 
        755                 760                 765             


Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Val 
    770                 775                 780                 


Pro Lys Asn Thr Ser Gln Thr Ala Ala Ile Thr Thr Lys Gly Gly Leu 
785                 790                 795                 800 


Val Gly Leu Val Asp Tyr Pro Asp Asp Asp Glu Asp Asp Asp Glu Asp 
                805                 810                 815     


Glu Asp Lys Glu Asp Thr Leu Pro Leu Ser Lys Lys Ala Lys Phe Asp 
            820                 825                 830         


Ser 
    


<210> 9095
<211> 1328
<212> PRT
<213> Homo sapiens

<400> 9095
Met Trp Arg Arg Lys His Pro Arg Thr Ser Gly Gly Thr Arg Gly Val 
1               5                   10                  15      


Leu Ser Gly Asn Arg Gly Val Glu Tyr Gly Ser Gly Arg Gly His Leu 
            20                  25                  30          


Gly Thr Phe Glu Gly Arg Trp Arg Lys Leu Pro Lys Met Pro Glu Ala 
        35                  40                  45              


Val Gly Thr Asp Pro Ser Thr Ser Arg Lys Met Ala Glu Leu Glu Glu 
    50                  55                  60                  


Val Thr Leu Asp Gly Lys Pro Leu Gln Ala Leu Arg Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Ala Leu Glu Gln Arg Gly Leu Ala Lys Ser Gly Gln Lys Ser 
                85                  90                  95      


Ala Leu Val Lys Arg Leu Lys Gly Ala Leu Met Leu Glu Asn Leu Gln 
            100                 105                 110         


Lys His Ser Thr Pro His Ala Ala Phe Gln Pro Asn Ser Gln Ile Gly 
        115                 120                 125             


Glu Glu Met Ser Gln Asn Ser Phe Ile Lys Gln Tyr Leu Glu Lys Gln 
    130                 135                 140                 


Gln Glu Leu Leu Arg Gln Arg Leu Glu Arg Glu Ala Arg Glu Ala Ala 
145                 150                 155                 160 


Glu Leu Glu Glu Ala Ser Ala Glu Ser Glu Asp Glu Met Ile His Pro 
                165                 170                 175     


Glu Gly Val Ala Ser Leu Leu Pro Pro Asp Phe Gln Ser Ser Leu Glu 
            180                 185                 190         


Arg Pro Glu Leu Glu Leu Ser Arg His Ser Pro Arg Lys Ser Ser Ser 
        195                 200                 205             


Ile Ser Glu Glu Lys Gly Asp Ser Asp Asp Glu Lys Pro Arg Lys Gly 
    210                 215                 220                 


Glu Arg Arg Ser Ser Arg Val Arg Gln Ala Arg Ala Ala Lys Leu Ser 
225                 230                 235                 240 


Glu Gly Ser Gln Pro Ala Glu Glu Glu Glu Asp Gln Glu Thr Pro Ser 
                245                 250                 255     


Arg Asn Leu Arg Val Arg Ala Asp Arg Asn Leu Lys Thr Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Gly 
        275                 280                 285             


Asp Asp Glu Gly Gln Lys Ser Arg Glu Ala Pro Ile Leu Lys Glu Phe 
    290                 295                 300                 


Lys Glu Glu Gly Glu Glu Ile Pro Arg Val Lys Pro Glu Glu Met Met 
305                 310                 315                 320 


Asp Glu Arg Pro Lys Thr Arg Ser Gln Glu Gln Glu Val Leu Glu Arg 
                325                 330                 335     


Gly Gly Arg Phe Thr Arg Ser Gln Glu Glu Ala Arg Lys Ser His Leu 
            340                 345                 350         


Ala Arg Gln Gln Gln Glu Lys Glu Met Lys Thr Thr Ser Pro Leu Glu 
        355                 360                 365             


Glu Glu Glu Arg Glu Ile Lys Ser Ser Gln Gly Leu Lys Glu Lys Ser 
    370                 375                 380                 


Lys Ser Pro Ser Pro Pro Arg Leu Thr Glu Asp Arg Lys Lys Ala Ser 
385                 390                 395                 400 


Leu Val Ala Leu Pro Glu Gln Thr Ala Ser Glu Glu Glu Thr Pro Pro 
                405                 410                 415     


Pro Leu Leu Thr Lys Glu Ala Ser Ser Pro Pro Pro His Pro Gln Leu 
            420                 425                 430         


His Ser Glu Glu Glu Ile Glu Pro Met Glu Gly Pro Ala Pro Ala Val 
        435                 440                 445             


Leu Ile Gln Leu Ser Pro Pro Asn Thr Asp Ala Asp Thr Arg Glu Leu 
    450                 455                 460                 


Leu Val Ser Gln His Thr Val Gln Leu Val Gly Gly Leu Ser Pro Leu 
465                 470                 475                 480 


Ser Ser Pro Ser Asp Thr Lys Ala Glu Ser Pro Ala Glu Lys Val Pro 
                485                 490                 495     


Glu Glu Ser Val Leu P